                         SEQUENCE LISTING

<110>  Poseida Therapeutics, Inc.
       Ostertag, Eric M.
       Shedlock, Devon
 
<120>  VCAR COMPOSITIONS AND METHODS FOR USE

<130>  POTH-034/001WO

<150>  US 62/608,571
<151>  2017-12-20

<150>  US 62/608,894
<151>  2017-12-21

<160>  18080 

<170>  PatentIn version 3.5

<210>  1
<211>  306
<212>  PRT
<213>  Homo Sapiens

<400>  1

Leu Thr Cys Gln Ala His Leu Glu Thr Pro Asp Phe Gln Leu Phe Lys 
1               5                   10                  15      


Asn Gly Val Ala Gln Glu Pro Val His Leu Asp Ser Pro Ala Ile Lys 
            20                  25                  30          


His Gln Phe Leu Leu Thr Gly Asp Thr Gln Gly Arg Tyr Arg Cys Arg 
        35                  40                  45              


Ser Gly Leu Ser Thr Gly Trp Thr Gln Leu Ser Lys Leu Leu Glu Leu 
    50                  55                  60                  


Thr Gly Pro Lys Ser Leu Pro Ala Pro Trp Leu Ser Met Ala Pro Val 
65                  70                  75                  80  


Ser Trp Ile Thr Pro Gly Leu Lys Thr Thr Ala Val Cys Arg Gly Val 
                85                  90                  95      


Leu Arg Gly Val Thr Phe Leu Leu Arg Arg Glu Gly Asp His Glu Phe 
            100                 105                 110         


Leu Glu Val Pro Glu Ala Gln Glu Asp Val Glu Ala Thr Phe Pro Val 
        115                 120                 125             


His Gln Pro Gly Asn Tyr Ser Cys Ser Tyr Arg Thr Asp Gly Glu Gly 
    130                 135                 140                 


Ala Leu Ser Glu Pro Ser Ala Thr Val Thr Ile Glu Glu Leu Gly Pro 
145                 150                 155                 160 


Gly Pro Gly Ser Trp Pro His Gly Cys Leu Gly Leu Met Val Ala Lys 
                165                 170                 175     


Glu Phe Gly Gln Arg Met Pro Lys Glu Trp Lys Ala Ala Pro Pro Pro 
            180                 185                 190         


Pro Val Leu Met His His Gly Glu Ser Ser Gln Val Leu His Pro Gly 
        195                 200                 205             


Asn Lys Val Thr Leu Thr Cys Val Ala Pro Leu Ser Gly Val Asp Phe 
    210                 215                 220                 


Gln Leu Arg Arg Gly Glu Lys Glu Leu Leu Val Pro Arg Ser Ser Thr 
225                 230                 235                 240 


Ser Pro Asp Arg Ile Phe Phe His Leu Asn Ala Val Ala Leu Gly Asp 
                245                 250                 255     


Gly Gly His Tyr Thr Cys Arg Tyr Arg Leu His Asp Asn Gln Asn Gly 
            260                 265                 270         


Trp Ser Gly Asp Ser Ala Pro Val Glu Leu Ile Leu Ser Asp Glu Thr 
        275                 280                 285             


Leu Pro Ala Pro Glu Phe Ser Pro Glu Pro Glu Ser Gly Arg Ala Leu 
    290                 295                 300                 


Arg Leu 
305     


<210>  2
<211>  495
<212>  PRT
<213>  Homo Sapiens

<400>  2

Met Ser Met Leu Val Val Phe Leu Leu Leu Trp Gly Val Thr Trp Gly 
1               5                   10                  15      


Pro Val Thr Glu Ala Ala Ile Phe Tyr Glu Thr Gln Pro Ser Leu Trp 
            20                  25                  30          


Ala Glu Ser Glu Ser Leu Leu Lys Pro Leu Ala Asn Val Thr Leu Thr 
        35                  40                  45              


Cys Gln Ala His Leu Glu Thr Pro Asp Phe Gln Leu Phe Lys Asn Gly 
    50                  55                  60                  


Val Ala Gln Glu Pro Val His Leu Asp Ser Pro Ala Ile Lys His Gln 
65                  70                  75                  80  


Phe Leu Leu Thr Gly Asp Thr Gln Gly Arg Tyr Arg Cys Arg Ser Gly 
                85                  90                  95      


Leu Ser Thr Gly Trp Thr Gln Leu Ser Lys Leu Leu Glu Leu Thr Gly 
            100                 105                 110         


Pro Lys Ser Leu Pro Ala Pro Trp Leu Ser Met Ala Pro Val Ser Trp 
        115                 120                 125             


Ile Thr Pro Gly Leu Lys Thr Thr Ala Val Cys Arg Gly Val Leu Arg 
    130                 135                 140                 


Gly Val Thr Phe Leu Leu Arg Arg Glu Gly Asp His Glu Phe Leu Glu 
145                 150                 155                 160 


Val Pro Glu Ala Gln Glu Asp Val Glu Ala Thr Phe Pro Val His Gln 
                165                 170                 175     


Pro Gly Asn Tyr Ser Cys Ser Tyr Arg Thr Asp Gly Glu Gly Ala Leu 
            180                 185                 190         


Ser Glu Pro Ser Ala Thr Val Thr Ile Glu Glu Leu Ala Ala Pro Pro 
        195                 200                 205             


Pro Pro Val Leu Met His His Gly Glu Ser Ser Gln Val Leu His Pro 
    210                 215                 220                 


Gly Asn Lys Val Thr Leu Thr Cys Val Ala Pro Leu Ser Gly Val Asp 
225                 230                 235                 240 


Phe Gln Leu Arg Arg Gly Glu Lys Glu Leu Leu Val Pro Arg Ser Ser 
                245                 250                 255     


Thr Ser Pro Asp Arg Ile Phe Phe His Leu Asn Ala Val Ala Leu Gly 
            260                 265                 270         


Asp Gly Gly His Tyr Thr Cys Arg Tyr Arg Leu His Asp Asn Gln Asn 
        275                 280                 285             


Gly Trp Ser Gly Asp Ser Ala Pro Val Glu Leu Ile Leu Ser Asp Glu 
    290                 295                 300                 


Thr Leu Pro Ala Pro Glu Phe Ser Pro Glu Pro Glu Ser Gly Arg Ala 
305                 310                 315                 320 


Leu Arg Leu Arg Cys Leu Ala Pro Leu Glu Gly Ala Arg Phe Ala Leu 
                325                 330                 335     


Val Arg Glu Asp Arg Gly Gly Arg Arg Val His Arg Phe Gln Ser Pro 
            340                 345                 350         


Ala Gly Thr Glu Ala Leu Phe Glu Leu His Asn Ile Ser Val Ala Asp 
        355                 360                 365             


Ser Ala Asn Tyr Ser Cys Val Tyr Val Asp Leu Lys Pro Pro Phe Gly 
    370                 375                 380                 


Gly Ser Ala Pro Ser Glu Arg Leu Glu Leu His Val Asp Gly Pro Pro 
385                 390                 395                 400 


Pro Arg Pro Gln Leu Arg Ala Thr Trp Ser Gly Ala Val Leu Ala Gly 
                405                 410                 415     


Arg Asp Ala Val Leu Arg Cys Glu Gly Pro Ile Pro Asp Val Thr Phe 
            420                 425                 430         


Glu Leu Leu Arg Glu Gly Glu Thr Lys Ala Val Lys Thr Val Arg Thr 
        435                 440                 445             


Pro Gly Ala Ala Ala Asn Leu Glu Leu Ile Phe Val Gly Pro Gln His 
    450                 455                 460                 


Ala Gly Asn Tyr Arg Cys Arg Tyr Arg Ser Trp Val Pro His Thr Phe 
465                 470                 475                 480 


Glu Ser Glu Leu Ser Asp Pro Val Glu Leu Leu Val Ala Glu Ser 
                485                 490                 495 


<210>  3
<211>  90
<212>  PRT
<213>  Homo Sapiens

<400>  3

Met Gly Lys Asn Lys Leu Leu His Pro Ser Leu Val Leu Leu Leu Leu 
1               5                   10                  15      


Val Leu Leu Pro Thr Asp Ala Ser Val Ser Gly Lys Pro Gln Tyr Met 
            20                  25                  30          


Val Leu Val Pro Ser Leu Leu His Thr Glu Thr Thr Glu Lys Gly Cys 
        35                  40                  45              


Val Leu Leu Ser Tyr Leu Asn Glu Thr Val Thr Val Ser Ala Ser Leu 
    50                  55                  60                  


Glu Ser Val Arg Gly Asn Arg Ser Leu Phe Thr Asp Leu Glu Ala Glu 
65                  70                  75                  80  


Asn Asp Val Leu His Cys Val Ala Phe Ala 
                85                  90  


<210>  4
<211>  168
<212>  PRT
<213>  Homo Sapiens

<400>  4

Met Gly Lys Asn Lys Leu Leu His Pro Ser Leu Val Leu Leu Leu Leu 
1               5                   10                  15      


Val Leu Leu Pro Thr Asp Ala Ser Val Ser Gly Lys Pro Gln Tyr Met 
            20                  25                  30          


Val Leu Val Pro Ser Leu Leu His Thr Glu Thr Thr Glu Lys Gly Cys 
        35                  40                  45              


Val Leu Leu Ser Tyr Leu Asn Glu Thr Val Thr Val Ser Ala Ser Leu 
    50                  55                  60                  


Glu Ser Val Arg Gly Asn Arg Ser Leu Phe Thr Asp Leu Glu Ala Glu 
65                  70                  75                  80  


Asn Asp Val Leu His Cys Val Ala Phe Ala Val Pro Lys Ser Ser Ser 
                85                  90                  95      


Asn Glu Glu Val Met Phe Leu Thr Val Gln Val Lys Gly Pro Thr Gln 
            100                 105                 110         


Glu Phe Lys Lys Arg Thr Thr Val Met Val Lys Asn Glu Asp Ser Leu 
        115                 120                 125             


Val Phe Val Gln Thr Asp Lys Ser Ile Tyr Lys Pro Gly Gln Thr Val 
    130                 135                 140                 


Lys Phe Arg Val Val Ser Met Asp Glu Asn Phe His Pro Leu Asn Glu 
145                 150                 155                 160 


Leu Ile Pro Leu Val Tyr Ile Gln 
                165             


<210>  5
<211>  1474
<212>  PRT
<213>  Homo Sapiens

<400>  5

Met Gly Lys Asn Lys Leu Leu His Pro Ser Leu Val Leu Leu Leu Leu 
1               5                   10                  15      


Val Leu Leu Pro Thr Asp Ala Ser Val Ser Gly Lys Pro Gln Tyr Met 
            20                  25                  30          


Val Leu Val Pro Ser Leu Leu His Thr Glu Thr Thr Glu Lys Gly Cys 
        35                  40                  45              


Val Leu Leu Ser Tyr Leu Asn Glu Thr Val Thr Val Ser Ala Ser Leu 
    50                  55                  60                  


Glu Ser Val Arg Gly Asn Arg Ser Leu Phe Thr Asp Leu Glu Ala Glu 
65                  70                  75                  80  


Asn Asp Val Leu His Cys Val Ala Phe Ala Val Pro Lys Ser Ser Ser 
                85                  90                  95      


Asn Glu Glu Val Met Phe Leu Thr Val Gln Val Lys Gly Pro Thr Gln 
            100                 105                 110         


Glu Phe Lys Lys Arg Thr Thr Val Met Val Lys Asn Glu Asp Ser Leu 
        115                 120                 125             


Val Phe Val Gln Thr Asp Lys Ser Ile Tyr Lys Pro Gly Gln Thr Val 
    130                 135                 140                 


Lys Phe Arg Val Val Ser Met Asp Glu Asn Phe His Pro Leu Asn Glu 
145                 150                 155                 160 


Leu Ile Pro Leu Val Tyr Ile Gln Asp Pro Lys Gly Asn Arg Ile Ala 
                165                 170                 175     


Gln Trp Gln Ser Phe Gln Leu Glu Gly Gly Leu Lys Gln Phe Ser Phe 
            180                 185                 190         


Pro Leu Ser Ser Glu Pro Phe Gln Gly Ser Tyr Lys Val Val Val Gln 
        195                 200                 205             


Lys Lys Ser Gly Gly Arg Thr Glu His Pro Phe Thr Val Glu Glu Phe 
    210                 215                 220                 


Val Leu Pro Lys Phe Glu Val Gln Val Thr Val Pro Lys Ile Ile Thr 
225                 230                 235                 240 


Ile Leu Glu Glu Glu Met Asn Val Ser Val Cys Gly Leu Tyr Thr Tyr 
                245                 250                 255     


Gly Lys Pro Val Pro Gly His Val Thr Val Ser Ile Cys Arg Lys Tyr 
            260                 265                 270         


Ser Asp Ala Ser Asp Cys His Gly Glu Asp Ser Gln Ala Phe Cys Glu 
        275                 280                 285             


Lys Phe Ser Gly Gln Leu Asn Ser His Gly Cys Phe Tyr Gln Gln Val 
    290                 295                 300                 


Lys Thr Lys Val Phe Gln Leu Lys Arg Lys Glu Tyr Glu Met Lys Leu 
305                 310                 315                 320 


His Thr Glu Ala Gln Ile Gln Glu Glu Gly Thr Val Val Glu Leu Thr 
                325                 330                 335     


Gly Arg Gln Ser Ser Glu Ile Thr Arg Thr Ile Thr Lys Leu Ser Phe 
            340                 345                 350         


Val Lys Val Asp Ser His Phe Arg Gln Gly Ile Pro Phe Phe Gly Gln 
        355                 360                 365             


Val Arg Leu Val Asp Gly Lys Gly Val Pro Ile Pro Asn Lys Val Ile 
    370                 375                 380                 


Phe Ile Arg Gly Asn Glu Ala Asn Tyr Tyr Ser Asn Ala Thr Thr Asp 
385                 390                 395                 400 


Glu His Gly Leu Val Gln Phe Ser Ile Asn Thr Thr Asn Val Met Gly 
                405                 410                 415     


Thr Ser Leu Thr Val Arg Val Asn Tyr Lys Asp Arg Ser Pro Cys Tyr 
            420                 425                 430         


Gly Tyr Gln Trp Val Ser Glu Glu His Glu Glu Ala His His Thr Ala 
        435                 440                 445             


Tyr Leu Val Phe Ser Pro Ser Lys Ser Phe Val His Leu Glu Pro Met 
    450                 455                 460                 


Ser His Glu Leu Pro Cys Gly His Thr Gln Thr Val Gln Ala His Tyr 
465                 470                 475                 480 


Ile Leu Asn Gly Gly Thr Leu Leu Gly Leu Lys Lys Leu Ser Phe Tyr 
                485                 490                 495     


Tyr Leu Ile Met Ala Lys Gly Gly Ile Val Arg Thr Gly Thr His Gly 
            500                 505                 510         


Leu Leu Val Lys Gln Glu Asp Met Lys Gly His Phe Ser Ile Ser Ile 
        515                 520                 525             


Pro Val Lys Ser Asp Ile Ala Pro Val Ala Arg Leu Leu Ile Tyr Ala 
    530                 535                 540                 


Val Leu Pro Thr Gly Asp Val Ile Gly Asp Ser Ala Lys Tyr Asp Val 
545                 550                 555                 560 


Glu Asn Cys Leu Ala Asn Lys Val Asp Leu Ser Phe Ser Pro Ser Gln 
                565                 570                 575     


Ser Leu Pro Ala Ser His Ala His Leu Arg Val Thr Ala Ala Pro Gln 
            580                 585                 590         


Ser Val Cys Ala Leu Arg Ala Val Asp Gln Ser Val Leu Leu Met Lys 
        595                 600                 605             


Pro Asp Ala Glu Leu Ser Ala Ser Ser Val Tyr Asn Leu Leu Pro Glu 
    610                 615                 620                 


Lys Asp Leu Thr Gly Phe Pro Gly Pro Leu Asn Asp Gln Asp Asn Glu 
625                 630                 635                 640 


Asp Cys Ile Asn Arg His Asn Val Tyr Ile Asn Gly Ile Thr Tyr Thr 
                645                 650                 655     


Pro Val Ser Ser Thr Asn Glu Lys Asp Met Tyr Ser Phe Leu Glu Asp 
            660                 665                 670         


Met Gly Leu Lys Ala Phe Thr Asn Ser Lys Ile Arg Lys Pro Lys Met 
        675                 680                 685             


Cys Pro Gln Leu Gln Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg 
    690                 695                 700                 


Val Gly Phe Tyr Glu Ser Asp Val Met Gly Arg Gly His Ala Arg Leu 
705                 710                 715                 720 


Val His Val Glu Glu Pro His Thr Glu Thr Val Arg Lys Tyr Phe Pro 
                725                 730                 735     


Glu Thr Trp Ile Trp Asp Leu Val Val Val Asn Ser Ala Gly Val Ala 
            740                 745                 750         


Glu Val Gly Val Thr Val Pro Asp Thr Ile Thr Glu Trp Lys Ala Gly 
        755                 760                 765             


Ala Phe Cys Leu Ser Glu Asp Ala Gly Leu Gly Ile Ser Ser Thr Ala 
    770                 775                 780                 


Ser Leu Arg Ala Phe Gln Pro Phe Phe Val Glu Leu Thr Met Pro Tyr 
785                 790                 795                 800 


Ser Val Ile Arg Gly Glu Ala Phe Thr Leu Lys Ala Thr Val Leu Asn 
                805                 810                 815     


Tyr Leu Pro Lys Cys Ile Arg Val Ser Val Gln Leu Glu Ala Ser Pro 
            820                 825                 830         


Ala Phe Leu Ala Val Pro Val Glu Lys Glu Gln Ala Pro His Cys Ile 
        835                 840                 845             


Cys Ala Asn Gly Arg Gln Thr Val Ser Trp Ala Val Thr Pro Lys Ser 
    850                 855                 860                 


Leu Gly Asn Val Asn Phe Thr Val Ser Ala Glu Ala Leu Glu Ser Gln 
865                 870                 875                 880 


Glu Leu Cys Gly Thr Glu Val Pro Ser Val Pro Glu His Gly Arg Lys 
                885                 890                 895     


Asp Thr Val Ile Lys Pro Leu Leu Val Glu Pro Glu Gly Leu Glu Lys 
            900                 905                 910         


Glu Thr Thr Phe Asn Ser Leu Leu Cys Pro Ser Gly Gly Glu Val Ser 
        915                 920                 925             


Glu Glu Leu Ser Leu Lys Leu Pro Pro Asn Val Val Glu Glu Ser Ala 
    930                 935                 940                 


Arg Ala Ser Val Ser Val Leu Gly Asp Ile Leu Gly Ser Ala Met Gln 
945                 950                 955                 960 


Asn Thr Gln Asn Leu Leu Gln Met Pro Tyr Gly Cys Gly Glu Gln Asn 
                965                 970                 975     


Met Val Leu Phe Ala Pro Asn Ile Tyr Val Leu Asp Tyr Leu Asn Glu 
            980                 985                 990         


Thr Gln Gln Leu Thr Pro Glu Ile  Lys Ser Lys Ala Ile  Gly Tyr Leu 
        995                 1000                 1005             


Asn Thr  Gly Tyr Gln Arg Gln  Leu Asn Tyr Lys His  Tyr Asp Gly 
    1010                 1015                 1020             


Ser Tyr  Ser Thr Phe Gly Glu  Arg Tyr Gly Arg Asn  Gln Gly Asn 
    1025                 1030                 1035             


Thr Trp  Leu Thr Ala Phe Val  Leu Lys Thr Phe Ala  Gln Ala Arg 
    1040                 1045                 1050             


Ala Tyr  Ile Phe Ile Asp Glu  Ala His Ile Thr Gln  Ala Leu Ile 
    1055                 1060                 1065             


Trp Leu  Ser Gln Arg Gln Lys  Asp Asn Gly Cys Phe  Arg Ser Ser 
    1070                 1075                 1080             


Gly Ser  Leu Leu Asn Asn Ala  Ile Lys Gly Gly Val  Glu Asp Glu 
    1085                 1090                 1095             


Val Thr  Leu Ser Ala Tyr Ile  Thr Ile Ala Leu Leu  Glu Ile Pro 
    1100                 1105                 1110             


Leu Thr  Val Thr His Pro Val  Val Arg Asn Ala Leu  Phe Cys Leu 
    1115                 1120                 1125             


Glu Ser  Ala Trp Lys Thr Ala  Gln Glu Gly Asp His  Gly Ser His 
    1130                 1135                 1140             


Val Tyr  Thr Lys Ala Leu Leu  Ala Tyr Ala Phe Ala  Leu Ala Gly 
    1145                 1150                 1155             


Asn Gln  Asp Lys Arg Lys Glu  Val Leu Lys Ser Leu  Asn Glu Glu 
    1160                 1165                 1170             


Ala Val  Lys Lys Asp Asn Ser  Val His Trp Glu Arg  Pro Gln Lys 
    1175                 1180                 1185             


Pro Lys  Ala Pro Val Gly His  Phe Tyr Glu Pro Gln  Ala Pro Ser 
    1190                 1195                 1200             


Ala Glu  Val Glu Met Thr Ser  Tyr Val Leu Leu Ala  Tyr Leu Thr 
    1205                 1210                 1215             


Ala Gln  Pro Ala Pro Thr Ser  Glu Asp Leu Thr Ser  Ala Thr Asn 
    1220                 1225                 1230             


Ile Val  Lys Trp Ile Thr Lys  Gln Gln Asn Ala Gln  Gly Gly Phe 
    1235                 1240                 1245             


Ser Ser  Thr Gln Asp Thr Val  Val Ala Leu His Ala  Leu Ser Lys 
    1250                 1255                 1260             


Tyr Gly  Ala Ala Thr Phe Thr  Arg Thr Gly Lys Ala  Ala Gln Val 
    1265                 1270                 1275             


Thr Ile  Gln Ser Ser Gly Thr  Phe Ser Ser Lys Phe  Gln Val Asp 
    1280                 1285                 1290             


Asn Asn  Asn Arg Leu Leu Leu  Gln Gln Val Ser Leu  Pro Glu Leu 
    1295                 1300                 1305             


Pro Gly  Glu Tyr Ser Met Lys  Val Thr Gly Glu Gly  Cys Val Tyr 
    1310                 1315                 1320             


Leu Gln  Thr Ser Leu Lys Tyr  Asn Ile Leu Pro Glu  Lys Glu Glu 
    1325                 1330                 1335             


Phe Pro  Phe Ala Leu Gly Val  Gln Thr Leu Pro Gln  Thr Cys Asp 
    1340                 1345                 1350             


Glu Pro  Lys Ala His Thr Ser  Phe Gln Ile Ser Leu  Ser Val Ser 
    1355                 1360                 1365             


Tyr Thr  Gly Ser Arg Ser Ala  Ser Asn Met Ala Ile  Val Asp Val 
    1370                 1375                 1380             


Lys Met  Val Ser Gly Phe Ile  Pro Leu Lys Pro Thr  Val Lys Met 
    1385                 1390                 1395             


Leu Glu  Arg Ser Asn His Val  Ser Arg Thr Glu Val  Ser Ser Asn 
    1400                 1405                 1410             


His Val  Leu Ile Tyr Leu Asp  Lys Val Ser Asn Gln  Thr Leu Ser 
    1415                 1420                 1425             


Leu Phe  Phe Thr Val Leu Gln  Asp Val Pro Val Arg  Asp Leu Lys 
    1430                 1435                 1440             


Pro Ala  Ile Val Lys Val Tyr  Asp Tyr Tyr Glu Thr  Asp Glu Phe 
    1445                 1450                 1455             


Ala Ile  Ala Glu Tyr Asn Ala  Pro Cys Ser Lys Asp  Leu Gly Asn 
    1460                 1465                 1470             


Ala 
    


<210>  6
<211>  73
<212>  PRT
<213>  Homo Sapiens

<400>  6

Asn Gly Gly Thr Leu Leu Gly Leu Lys Lys Leu Ser Phe Tyr Tyr Leu 
1               5                   10                  15      


Ile Met Ala Lys Gly Gly Ile Val Arg Thr Gly Thr His Gly Leu Leu 
            20                  25                  30          


Val Lys Gln Glu Asp Met Lys Gly His Phe Ser Ile Ser Ile Pro Val 
        35                  40                  45              


Lys Ser Asp Ile Ala Pro Val Ala Arg Phe Thr Thr Cys Tyr Gln Lys 
    50                  55                  60                  


Arg Thr Ser Leu Ala Ser Leu Gly Leu 
65                  70              


<210>  7
<211>  183
<212>  PRT
<213>  Homo Sapiens

<400>  7

Met Leu Gly Glu Leu Ile Gly Lys Gly Ser Leu Val Met Glu Gly Gln 
1               5                   10                  15      


Lys His Leu Asn Ser Lys Lys Lys Gly Leu Lys Ala Ser Phe Ser Leu 
            20                  25                  30          


Ser Leu Thr Phe Thr Ser Arg Leu Ala Pro Asp Pro Ser Leu Val Ile 
        35                  40                  45              


Tyr Ala Ile Phe Pro Ser Gly Gly Val Val Ala Asp Lys Ile Gln Phe 
    50                  55                  60                  


Ser Val Glu Met Cys Phe Asp Asn Gln Val Ser Leu Gly Phe Ser Pro 
65                  70                  75                  80  


Ser Gln Gln Leu Pro Gly Ala Glu Val Glu Leu Gln Leu Gln Ala Ala 
                85                  90                  95      


Pro Gly Ser Leu Cys Ala Leu Arg Ala Val Asp Glu Ser Val Leu Leu 
            100                 105                 110         


Leu Arg Pro Asp Arg Glu Leu Ser Asn Arg Ser Val Tyr Gly Met Phe 
        115                 120                 125             


Pro Phe Trp Tyr Gly His Tyr Pro Tyr Gln Val Ala Glu Tyr Asp Gln 
    130                 135                 140                 


Cys Pro Val Ser Gly Pro Trp Asp Phe Pro Gln Pro Leu Ile Asp Pro 
145                 150                 155                 160 


Met Pro Gln Gly His Ser Ser Gln Arg Ser Ile Ile Trp Arg Pro Ser 
                165                 170                 175     


Phe Ser Glu Gly Thr Asp Leu 
            180             


<210>  8
<211>  963
<212>  PRT
<213>  Homo Sapiens

<400>  8

Met Leu Ile Gly Lys Gly Ser Leu Val Met Glu Gly Gln Lys His Leu 
1               5                   10                  15      


Asn Ser Lys Lys Lys Gly Leu Lys Ala Ser Phe Ser Leu Ser Leu Thr 
            20                  25                  30          


Phe Thr Ser Arg Leu Ala Pro Asp Pro Ser Leu Val Ile Tyr Ala Ile 
        35                  40                  45              


Phe Pro Ser Gly Gly Val Val Ala Asp Lys Ile Gln Phe Ser Val Glu 
    50                  55                  60                  


Met Cys Phe Asp Asn Gln Val Ser Leu Gly Phe Ser Pro Ser Gln Gln 
65                  70                  75                  80  


Leu Pro Gly Ala Glu Val Glu Leu Gln Leu Gln Ala Ala Pro Gly Ser 
                85                  90                  95      


Leu Cys Ala Leu Arg Ala Val Asp Glu Ser Val Leu Leu Leu Arg Pro 
            100                 105                 110         


Asp Arg Glu Leu Ser Asn Arg Ser Val Tyr Gly Met Phe Pro Phe Trp 
        115                 120                 125             


Tyr Gly His Tyr Pro Tyr Gln Val Ala Glu Tyr Asp Gln Cys Pro Val 
    130                 135                 140                 


Ser Gly Pro Trp Asp Phe Pro Gln Pro Leu Ile Asp Pro Met Pro Gln 
145                 150                 155                 160 


Gly His Ser Ser Gln Arg Ser Ile Ile Trp Arg Pro Ser Phe Ser Glu 
                165                 170                 175     


Gly Thr Asp Leu Phe Ser Phe Phe Arg Asp Val Gly Leu Lys Ile Leu 
            180                 185                 190         


Ser Asn Ala Lys Ile Lys Lys Pro Val Asp Cys Ser His Arg Ser Pro 
        195                 200                 205             


Glu Tyr Ser Thr Ala Met Gly Ala Gly Gly Gly His Pro Glu Ala Phe 
    210                 215                 220                 


Glu Ser Ser Thr Pro Leu His Gln Ala Glu Asp Ser Gln Val Arg Gln 
225                 230                 235                 240 


Tyr Phe Pro Glu Thr Trp Leu Trp Asp Leu Phe Pro Ile Gly Asn Ser 
                245                 250                 255     


Gly Lys Glu Ala Val His Val Thr Val Pro Asp Ala Ile Thr Glu Trp 
            260                 265                 270         


Lys Ala Met Ser Phe Cys Thr Ser Gln Ser Arg Gly Phe Gly Leu Ser 
        275                 280                 285             


Pro Thr Val Gly Leu Thr Ala Phe Lys Pro Phe Phe Val Asp Leu Thr 
    290                 295                 300                 


Leu Pro Tyr Ser Val Val Arg Gly Glu Ser Phe Arg Leu Thr Ala Thr 
305                 310                 315                 320 


Ile Phe Asn Tyr Leu Lys Asp Cys Ile Arg Val Gln Thr Asp Leu Ala 
                325                 330                 335     


Lys Ser His Glu Tyr Gln Leu Glu Ser Trp Ala Asp Ser Gln Thr Ser 
            340                 345                 350         


Ser Cys Leu Cys Ala Asp Asp Ala Lys Thr His His Trp Asn Ile Thr 
        355                 360                 365             


Ala Val Lys Leu Gly His Ile Asn Phe Thr Ile Ser Thr Lys Ile Leu 
    370                 375                 380                 


Asp Ser Asn Glu Pro Cys Gly Gly Gln Lys Gly Phe Val Pro Gln Lys 
385                 390                 395                 400 


Gly Arg Ser Asp Thr Leu Ile Lys Pro Val Leu Val Lys Pro Glu Gly 
                405                 410                 415     


Val Leu Val Glu Lys Thr His Ser Ser Leu Leu Cys Pro Lys Gly Lys 
            420                 425                 430         


Val Ala Ser Glu Ser Val Ser Leu Glu Leu Pro Val Asp Ile Val Pro 
        435                 440                 445             


Asp Ser Thr Lys Ala Tyr Val Thr Val Leu Gly Asp Ile Met Gly Thr 
    450                 455                 460                 


Ala Leu Gln Asn Leu Asp Gly Leu Val Gln Met Pro Ser Gly Cys Gly 
465                 470                 475                 480 


Glu Gln Asn Met Val Leu Phe Ala Pro Ile Ile Tyr Val Leu Gln Tyr 
                485                 490                 495     


Leu Glu Lys Ala Gly Leu Leu Thr Glu Glu Ile Arg Ser Arg Ala Val 
            500                 505                 510         


Gly Phe Leu Glu Ile Gly Tyr Gln Lys Glu Leu Met Tyr Lys His Ser 
        515                 520                 525             


Asn Gly Ser Tyr Ser Ala Phe Gly Glu Arg Asp Gly Asn Gly Asn Thr 
    530                 535                 540                 


Trp Leu Thr Ala Phe Val Thr Lys Cys Phe Gly Gln Ala Gln Lys Phe 
545                 550                 555                 560 


Ile Phe Ile Asp Pro Lys Asn Ile Gln Asp Ala Leu Lys Trp Met Ala 
                565                 570                 575     


Gly Asn Gln Leu Pro Ser Gly Cys Tyr Ala Asn Val Gly Asn Leu Leu 
            580                 585                 590         


His Thr Ala Met Lys Gly Gly Val Asp Asp Glu Val Ser Leu Thr Ala 
        595                 600                 605             


Tyr Val Thr Ala Ala Leu Leu Glu Met Gly Lys Asp Val Asp Asp Pro 
    610                 615                 620                 


Met Val Ser Gln Gly Leu Arg Cys Leu Lys Asn Ser Ala Thr Ser Thr 
625                 630                 635                 640 


Thr Asn Leu Tyr Thr Gln Ala Leu Leu Ala Tyr Ile Phe Ser Leu Ala 
                645                 650                 655     


Gly Glu Met Asp Ile Arg Asn Ile Leu Leu Lys Gln Leu Asp Gln Gln 
            660                 665                 670         


Ala Ile Ile Ser Gly Glu Ser Ile Tyr Trp Ser Gln Lys Pro Thr Pro 
        675                 680                 685             


Ser Ser Asn Ala Ser Pro Trp Ser Glu Pro Ala Ala Val Asp Val Glu 
    690                 695                 700                 


Leu Thr Ala Tyr Ala Leu Leu Ala Gln Leu Thr Lys Pro Ser Leu Thr 
705                 710                 715                 720 


Gln Lys Glu Ile Ala Lys Ala Thr Ser Ile Val Ala Trp Leu Ala Lys 
                725                 730                 735     


Gln His Asn Ala Tyr Gly Gly Phe Ser Ser Thr Gln Asp Thr Val Val 
            740                 745                 750         


Ala Leu Gln Ala Leu Ala Lys Tyr Ala Thr Thr Ala Tyr Met Pro Ser 
        755                 760                 765             


Glu Glu Ile Asn Leu Val Val Lys Ser Thr Glu Asn Phe Gln Arg Thr 
    770                 775                 780                 


Phe Asn Ile Gln Ser Val Asn Arg Leu Val Phe Gln Gln Asp Thr Leu 
785                 790                 795                 800 


Pro Asn Val Pro Gly Met Tyr Thr Leu Glu Ala Ser Gly Gln Gly Cys 
                805                 810                 815     


Val Tyr Val Gln Thr Val Leu Arg Tyr Asn Ile Leu Pro Pro Thr Asn 
            820                 825                 830         


Met Lys Thr Phe Ser Leu Ser Val Glu Ile Gly Lys Ala Arg Cys Glu 
        835                 840                 845             


Gln Pro Thr Ser Pro Arg Ser Leu Thr Leu Thr Ile His Thr Ser Tyr 
    850                 855                 860                 


Val Gly Ser Arg Ser Ser Ser Asn Met Ala Ile Val Glu Val Lys Met 
865                 870                 875                 880 


Leu Ser Gly Phe Ser Pro Met Glu Gly Thr Asn Gln Leu Leu Leu Gln 
                885                 890                 895     


Gln Pro Leu Val Lys Lys Val Glu Phe Gly Thr Asp Thr Leu Asn Ile 
            900                 905                 910         


Tyr Leu Asp Glu Leu Ile Lys Asn Thr Gln Thr Tyr Thr Phe Thr Ile 
        915                 920                 925             


Ser Gln Ser Val Leu Val Thr Asn Leu Lys Pro Ala Thr Ile Lys Val 
    930                 935                 940                 


Tyr Asp Tyr Tyr Leu Pro Asp Glu Gln Ala Thr Ile Gln Tyr Ser Asp 
945                 950                 955                 960 


Pro Cys Glu 
            


<210>  9
<211>  81
<212>  PRT
<213>  Homo Sapiens

<400>  9

Met Val Arg Asn Asn Phe Tyr Ala Val Arg Leu Leu Pro Ser Thr Cys 
1               5                   10                  15      


Val Val Leu Ser Gln Thr Ser Asn Cys Arg Arg Ser His Gln Asp Pro 
            20                  25                  30          


Leu Ala Ala Ser Cys Ile Cys Gln Ala Ser Gly Cys Trp Leu Ile Gly 
        35                  40                  45              


Lys Gly Ser Leu Val Met Glu Gly Gln Lys His Leu Asn Ser Lys Lys 
    50                  55                  60                  


Lys Gly Leu Lys Ala Ser Phe Ser Leu Ser Leu Thr Phe Thr Ser Arg 
65                  70                  75                  80  


Leu 
    


<210>  10
<211>  1454
<212>  PRT
<213>  Homo Sapiens

<400>  10

Met Trp Ala Gln Leu Leu Leu Gly Met Leu Ala Leu Ser Pro Ala Ile 
1               5                   10                  15      


Ala Glu Glu Leu Pro Asn Tyr Leu Val Thr Leu Pro Ala Arg Leu Asn 
            20                  25                  30          


Phe Pro Ser Val Gln Lys Val Cys Leu Asp Leu Ser Pro Gly Tyr Ser 
        35                  40                  45              


Asp Val Lys Phe Thr Val Thr Leu Glu Thr Lys Asp Lys Thr Gln Lys 
    50                  55                  60                  


Leu Leu Glu Tyr Ser Gly Leu Lys Lys Arg His Leu His Cys Ile Ser 
65                  70                  75                  80  


Phe Leu Val Pro Pro Pro Ala Gly Gly Thr Glu Glu Val Ala Thr Ile 
                85                  90                  95      


Arg Val Ser Gly Val Gly Asn Asn Ile Ser Phe Glu Glu Lys Lys Lys 
            100                 105                 110         


Val Leu Ile Gln Arg Gln Gly Asn Gly Thr Phe Val Gln Thr Asp Lys 
        115                 120                 125             


Pro Leu Tyr Thr Pro Gly Gln Gln Val Tyr Phe Arg Ile Val Thr Met 
    130                 135                 140                 


Asp Ser Asn Phe Val Pro Val Asn Asp Lys Tyr Ser Met Val Glu Leu 
145                 150                 155                 160 


Gln Asp Pro Asn Ser Asn Arg Ile Ala Gln Trp Leu Glu Val Val Pro 
                165                 170                 175     


Glu Gln Gly Ile Val Asp Leu Ser Phe Gln Leu Ala Pro Glu Ala Met 
            180                 185                 190         


Leu Gly Thr Tyr Thr Val Ala Val Ala Glu Gly Lys Thr Phe Gly Thr 
        195                 200                 205             


Phe Ser Val Glu Glu Tyr Val Leu Pro Lys Phe Lys Val Glu Val Val 
    210                 215                 220                 


Glu Pro Lys Glu Leu Ser Thr Val Gln Glu Ser Phe Leu Val Lys Ile 
225                 230                 235                 240 


Cys Cys Arg Tyr Thr Tyr Gly Lys Pro Met Leu Gly Ala Val Gln Val 
                245                 250                 255     


Ser Val Cys Gln Lys Ala Asn Thr Tyr Trp Tyr Arg Glu Val Glu Arg 
            260                 265                 270         


Glu Gln Leu Pro Asp Lys Cys Arg Asn Leu Ser Gly Gln Thr Asp Lys 
        275                 280                 285             


Thr Gly Cys Phe Ser Ala Pro Val Asp Met Ala Thr Phe Asp Leu Ile 
    290                 295                 300                 


Gly Tyr Ala Tyr Ser His Gln Ile Asn Ile Val Ala Thr Val Val Glu 
305                 310                 315                 320 


Glu Gly Thr Gly Val Glu Ala Asn Ala Thr Gln Asn Ile Tyr Ile Ser 
                325                 330                 335     


Pro Gln Met Gly Ser Met Thr Phe Glu Asp Thr Ser Asn Phe Tyr His 
            340                 345                 350         


Pro Asn Phe Pro Phe Ser Gly Lys Ile Arg Val Arg Gly His Asp Asp 
        355                 360                 365             


Ser Phe Leu Lys Asn His Leu Val Phe Leu Val Ile Tyr Gly Thr Asn 
    370                 375                 380                 


Gly Thr Phe Asn Gln Thr Leu Val Thr Asp Asn Asn Gly Leu Ala Pro 
385                 390                 395                 400 


Phe Thr Leu Glu Thr Ser Gly Trp Asn Gly Thr Asp Val Ser Leu Glu 
                405                 410                 415     


Gly Lys Phe Gln Met Glu Asp Leu Val Tyr Asn Pro Glu Gln Val Pro 
            420                 425                 430         


Arg Tyr Tyr Gln Asn Ala Tyr Leu His Leu Arg Pro Phe Tyr Ser Thr 
        435                 440                 445             


Thr Arg Ser Phe Leu Gly Ile His Arg Leu Asn Gly Pro Leu Lys Cys 
    450                 455                 460                 


Gly Gln Pro Gln Glu Val Leu Val Asp Tyr Tyr Ile Asp Pro Ala Asp 
465                 470                 475                 480 


Ala Ser Pro Asp Gln Glu Ile Ser Phe Ser Tyr Tyr Leu Ile Gly Lys 
                485                 490                 495     


Gly Ser Leu Val Met Glu Gly Gln Lys His Leu Asn Ser Lys Lys Lys 
            500                 505                 510         


Gly Leu Lys Ala Ser Phe Ser Leu Ser Leu Thr Phe Thr Ser Arg Leu 
        515                 520                 525             


Ala Pro Asp Pro Ser Leu Val Ile Tyr Ala Ile Phe Pro Ser Gly Gly 
    530                 535                 540                 


Val Val Ala Asp Lys Ile Gln Phe Ser Val Glu Met Cys Phe Asp Asn 
545                 550                 555                 560 


Gln Val Ser Leu Gly Phe Ser Pro Ser Gln Gln Leu Pro Gly Ala Glu 
                565                 570                 575     


Val Glu Leu Gln Leu Gln Ala Ala Pro Gly Ser Leu Cys Ala Leu Arg 
            580                 585                 590         


Ala Val Asp Glu Ser Val Leu Leu Leu Arg Pro Asp Arg Glu Leu Ser 
        595                 600                 605             


Asn Arg Ser Val Tyr Gly Met Phe Pro Phe Trp Tyr Gly His Tyr Pro 
    610                 615                 620                 


Tyr Gln Val Ala Glu Tyr Asp Gln Cys Pro Val Ser Gly Pro Trp Asp 
625                 630                 635                 640 


Phe Pro Gln Pro Leu Ile Asp Pro Met Pro Gln Gly His Ser Ser Gln 
                645                 650                 655     


Arg Ser Ile Ile Trp Arg Pro Ser Phe Ser Glu Gly Thr Asp Leu Phe 
            660                 665                 670         


Ser Phe Phe Arg Asp Val Gly Leu Lys Ile Leu Ser Asn Ala Lys Ile 
        675                 680                 685             


Lys Lys Pro Val Asp Cys Ser His Arg Ser Pro Glu Tyr Ser Thr Ala 
    690                 695                 700                 


Met Gly Ala Gly Gly Gly His Pro Glu Ala Phe Glu Ser Ser Thr Pro 
705                 710                 715                 720 


Leu His Gln Ala Glu Asp Ser Gln Val Arg Gln Tyr Phe Pro Glu Thr 
                725                 730                 735     


Trp Leu Trp Asp Leu Phe Pro Ile Gly Asn Ser Gly Lys Glu Ala Val 
            740                 745                 750         


His Val Thr Val Pro Asp Ala Ile Thr Glu Trp Lys Ala Met Ser Phe 
        755                 760                 765             


Cys Thr Ser Gln Ser Arg Gly Phe Gly Leu Ser Pro Thr Val Gly Leu 
    770                 775                 780                 


Thr Ala Phe Lys Pro Phe Phe Val Asp Leu Thr Leu Pro Tyr Ser Val 
785                 790                 795                 800 


Val Arg Gly Glu Ser Phe Arg Leu Thr Ala Thr Ile Phe Asn Tyr Leu 
                805                 810                 815     


Lys Asp Cys Ile Arg Val Gln Thr Asp Leu Ala Lys Ser His Glu Tyr 
            820                 825                 830         


Gln Leu Glu Ser Trp Ala Asp Ser Gln Thr Ser Ser Cys Leu Cys Ala 
        835                 840                 845             


Asp Asp Ala Lys Thr His His Trp Asn Ile Thr Ala Val Lys Leu Gly 
    850                 855                 860                 


His Ile Asn Phe Thr Ile Ser Thr Lys Ile Leu Asp Ser Asn Glu Pro 
865                 870                 875                 880 


Cys Gly Gly Gln Lys Gly Phe Val Pro Gln Lys Gly Arg Ser Asp Thr 
                885                 890                 895     


Leu Ile Lys Pro Val Leu Val Lys Pro Glu Gly Val Leu Val Glu Lys 
            900                 905                 910         


Thr His Ser Ser Leu Leu Cys Pro Lys Gly Lys Val Ala Ser Glu Ser 
        915                 920                 925             


Val Ser Leu Glu Leu Pro Val Asp Ile Val Pro Asp Ser Thr Lys Ala 
    930                 935                 940                 


Tyr Val Thr Val Leu Gly Asp Ile Met Gly Thr Ala Leu Gln Asn Leu 
945                 950                 955                 960 


Asp Gly Leu Val Gln Met Pro Ser Gly Cys Gly Glu Gln Asn Met Val 
                965                 970                 975     


Leu Phe Ala Pro Ile Ile Tyr Val Leu Gln Tyr Leu Glu Lys Ala Gly 
            980                 985                 990         


Leu Leu Thr Glu Glu Ile Arg Ser  Arg Ala Val Gly Phe  Leu Glu Ile 
        995                 1000                 1005             


Gly Tyr  Gln Lys Glu Leu Met  Tyr Lys His Ser Asn  Gly Ser Tyr 
    1010                 1015                 1020             


Ser Ala  Phe Gly Glu Arg Asp  Gly Asn Gly Asn Thr  Trp Leu Thr 
    1025                 1030                 1035             


Ala Phe  Val Thr Lys Cys Phe  Gly Gln Ala Gln Lys  Phe Ile Phe 
    1040                 1045                 1050             


Ile Asp  Pro Lys Asn Ile Gln  Asp Ala Leu Lys Trp  Met Ala Gly 
    1055                 1060                 1065             


Asn Gln  Leu Pro Ser Gly Cys  Tyr Ala Asn Val Gly  Asn Leu Leu 
    1070                 1075                 1080             


His Thr  Ala Met Lys Gly Gly  Val Asp Asp Glu Val  Ser Leu Thr 
    1085                 1090                 1095             


Ala Tyr  Val Thr Ala Ala Leu  Leu Glu Met Gly Lys  Asp Val Asp 
    1100                 1105                 1110             


Asp Pro  Met Val Ser Gln Gly  Leu Arg Cys Leu Lys  Asn Ser Ala 
    1115                 1120                 1125             


Thr Ser  Thr Thr Asn Leu Tyr  Thr Gln Ala Leu Leu  Ala Tyr Ile 
    1130                 1135                 1140             


Phe Ser  Leu Ala Gly Glu Met  Asp Ile Arg Asn Ile  Leu Leu Lys 
    1145                 1150                 1155             


Gln Leu  Asp Gln Gln Ala Ile  Ile Ser Gly Glu Ser  Ile Tyr Trp 
    1160                 1165                 1170             


Ser Gln  Lys Pro Thr Pro Ser  Ser Asn Ala Ser Pro  Trp Ser Glu 
    1175                 1180                 1185             


Pro Ala  Ala Val Asp Val Glu  Leu Thr Ala Tyr Ala  Leu Leu Ala 
    1190                 1195                 1200             


Gln Leu  Thr Lys Pro Ser Leu  Thr Gln Lys Glu Ile  Ala Lys Ala 
    1205                 1210                 1215             


Thr Ser  Ile Val Ala Trp Leu  Ala Lys Gln His Asn  Ala Tyr Gly 
    1220                 1225                 1230             


Gly Phe  Ser Ser Thr Gln Asp  Thr Val Val Ala Leu  Gln Ala Leu 
    1235                 1240                 1245             


Ala Lys  Tyr Ala Thr Thr Ala  Tyr Met Pro Ser Glu  Glu Ile Asn 
    1250                 1255                 1260             


Leu Val  Val Lys Ser Thr Glu  Asn Phe Gln Arg Thr  Phe Asn Ile 
    1265                 1270                 1275             


Gln Ser  Val Asn Arg Leu Val  Phe Gln Gln Asp Thr  Leu Pro Asn 
    1280                 1285                 1290             


Val Pro  Gly Met Tyr Thr Leu  Glu Ala Ser Gly Gln  Gly Cys Val 
    1295                 1300                 1305             


Tyr Val  Gln Thr Val Leu Arg  Tyr Asn Ile Leu Pro  Pro Thr Asn 
    1310                 1315                 1320             


Met Lys  Thr Phe Ser Leu Ser  Val Glu Ile Gly Lys  Ala Arg Cys 
    1325                 1330                 1335             


Glu Gln  Pro Thr Ser Pro Arg  Ser Leu Thr Leu Thr  Ile His Thr 
    1340                 1345                 1350             


Ser Tyr  Val Gly Ser Arg Ser  Ser Ser Asn Met Ala  Ile Val Glu 
    1355                 1360                 1365             


Val Lys  Met Leu Ser Gly Phe  Ser Pro Met Glu Gly  Thr Asn Gln 
    1370                 1375                 1380             


Leu Leu  Leu Gln Gln Pro Leu  Val Lys Lys Val Glu  Phe Gly Thr 
    1385                 1390                 1395             


Asp Thr  Leu Asn Ile Tyr Leu  Asp Glu Leu Ile Lys  Asn Thr Gln 
    1400                 1405                 1410             


Thr Tyr  Thr Phe Thr Ile Ser  Gln Ser Val Leu Val  Thr Asn Leu 
    1415                 1420                 1425             


Lys Pro  Ala Thr Ile Lys Val  Tyr Asp Tyr Tyr Leu  Pro Asp Glu 
    1430                 1435                 1440             


Gln Ala  Thr Ile Gln Tyr Ser  Asp Pro Cys Glu 
    1445                 1450                 


<210>  11
<211>  1004
<212>  PRT
<213>  Homo Sapiens

<400>  11

Ser Phe Leu Gly Ile His Arg Leu Asn Gly Pro Leu Lys Cys Gly Gln 
1               5                   10                  15      


Pro Gln Glu Val Leu Val Asp Tyr Tyr Ile Asp Pro Ala Asp Ala Ser 
            20                  25                  30          


Pro Asp Gln Glu Ile Ser Phe Ser Tyr Tyr Leu Ile Gly Lys Gly Ser 
        35                  40                  45              


Leu Val Met Glu Gly Gln Lys His Leu Asn Ser Lys Lys Lys Gly Leu 
    50                  55                  60                  


Lys Ala Ser Phe Ser Leu Ser Leu Thr Phe Thr Ser Arg Leu Ala Pro 
65                  70                  75                  80  


Asp Pro Ser Leu Val Ile Tyr Ala Ile Phe Pro Ser Gly Gly Val Val 
                85                  90                  95      


Ala Asp Lys Ile Gln Phe Ser Val Glu Met Cys Phe Asp Asn Gln Val 
            100                 105                 110         


Ser Leu Gly Phe Ser Pro Ser Gln Gln Leu Pro Gly Ala Glu Val Glu 
        115                 120                 125             


Leu Gln Leu Gln Ala Ala Pro Gly Ser Leu Cys Ala Leu Arg Ala Val 
    130                 135                 140                 


Asp Glu Ser Val Leu Leu Leu Arg Pro Asp Arg Glu Leu Ser Asn Arg 
145                 150                 155                 160 


Ser Val Tyr Gly Met Phe Pro Phe Trp Tyr Gly His Tyr Pro Tyr Gln 
                165                 170                 175     


Val Ala Glu Tyr Asp Gln Cys Pro Val Ser Gly Pro Trp Asp Phe Pro 
            180                 185                 190         


Gln Pro Leu Ile Asp Pro Met Pro Gln Gly His Ser Ser Gln Arg Ser 
        195                 200                 205             


Ile Ile Trp Arg Pro Ser Phe Ser Glu Gly Thr Asp Leu Phe Ser Phe 
    210                 215                 220                 


Phe Arg Asp Val Gly Leu Lys Ile Leu Ser Asn Ala Lys Ile Lys Lys 
225                 230                 235                 240 


Pro Val Asp Cys Ser His Arg Ser Pro Glu Tyr Ser Thr Ala Met Gly 
                245                 250                 255     


Ala Gly Gly Gly His Pro Glu Ala Phe Glu Ser Ser Thr Pro Leu His 
            260                 265                 270         


Gln Ala Glu Asp Ser Gln Val Arg Gln Tyr Phe Pro Glu Thr Trp Leu 
        275                 280                 285             


Trp Asp Leu Phe Pro Ile Gly Asn Ser Gly Lys Glu Ala Val His Val 
    290                 295                 300                 


Thr Val Pro Asp Ala Ile Thr Glu Trp Lys Ala Met Ser Phe Cys Thr 
305                 310                 315                 320 


Ser Gln Ser Arg Gly Phe Gly Leu Ser Pro Thr Val Gly Leu Thr Ala 
                325                 330                 335     


Phe Lys Pro Phe Phe Val Asp Leu Thr Leu Pro Tyr Ser Val Val Arg 
            340                 345                 350         


Gly Glu Ser Phe Arg Leu Thr Ala Thr Ile Phe Asn Tyr Leu Lys Asp 
        355                 360                 365             


Cys Ile Arg Val Gln Thr Asp Leu Ala Lys Ser His Glu Tyr Gln Leu 
    370                 375                 380                 


Glu Ser Trp Ala Asp Ser Gln Thr Ser Ser Cys Leu Cys Ala Asp Asp 
385                 390                 395                 400 


Ala Lys Thr His His Trp Asn Ile Thr Ala Val Lys Leu Gly His Ile 
                405                 410                 415     


Asn Phe Thr Ile Ser Thr Lys Ile Leu Asp Ser Asn Glu Pro Cys Gly 
            420                 425                 430         


Gly Gln Lys Gly Phe Val Pro Gln Lys Gly Arg Ser Asp Thr Leu Ile 
        435                 440                 445             


Lys Pro Val Leu Val Lys Pro Glu Gly Val Leu Val Glu Lys Thr His 
    450                 455                 460                 


Ser Ser Leu Leu Cys Pro Lys Gly Lys Val Ala Ser Glu Ser Val Ser 
465                 470                 475                 480 


Leu Glu Leu Pro Val Asp Ile Val Pro Asp Ser Thr Lys Ala Tyr Val 
                485                 490                 495     


Thr Val Leu Gly Asp Ile Met Gly Thr Ala Leu Gln Asn Leu Asp Gly 
            500                 505                 510         


Leu Val Gln Met Pro Ser Gly Cys Gly Glu Gln Asn Met Val Leu Phe 
        515                 520                 525             


Ala Pro Ile Ile Tyr Val Leu Gln Tyr Leu Glu Lys Ala Gly Leu Leu 
    530                 535                 540                 


Thr Glu Glu Ile Arg Ser Arg Ala Val Gly Phe Leu Glu Ile Gly Tyr 
545                 550                 555                 560 


Gln Lys Glu Leu Met Tyr Lys His Ser Asn Gly Ser Tyr Ser Ala Phe 
                565                 570                 575     


Gly Glu Arg Asp Gly Asn Gly Asn Thr Trp Leu Thr Ala Phe Val Thr 
            580                 585                 590         


Lys Cys Phe Gly Gln Ala Gln Lys Phe Ile Phe Ile Asp Pro Lys Asn 
        595                 600                 605             


Ile Gln Asp Ala Leu Lys Trp Met Ala Gly Asn Gln Leu Pro Ser Gly 
    610                 615                 620                 


Cys Tyr Ala Asn Val Gly Asn Leu Leu His Thr Ala Met Lys Gly Gly 
625                 630                 635                 640 


Val Asp Asp Glu Val Ser Leu Thr Ala Tyr Val Thr Ala Ala Leu Leu 
                645                 650                 655     


Glu Met Gly Lys Asp Val Asp Asp Pro Met Val Ser Gln Gly Leu Arg 
            660                 665                 670         


Cys Leu Lys Asn Ser Ala Thr Ser Thr Thr Asn Leu Tyr Thr Gln Ala 
        675                 680                 685             


Leu Leu Ala Tyr Ile Phe Ser Leu Ala Gly Glu Met Asp Ile Arg Asn 
    690                 695                 700                 


Ile Leu Leu Lys Gln Leu Asp Gln Gln Ala Ile Ile Ser Gly Glu Ser 
705                 710                 715                 720 


Ile Tyr Trp Ser Gln Lys Pro Thr Pro Ser Ser Asn Ala Ser Pro Trp 
                725                 730                 735     


Ser Glu Pro Ala Ala Val Asp Val Glu Leu Thr Ala Tyr Ala Leu Leu 
            740                 745                 750         


Ala Gln Leu Thr Lys Pro Ser Leu Thr Gln Lys Glu Ile Ala Lys Ala 
        755                 760                 765             


Thr Ser Ile Val Ala Trp Leu Ala Lys Gln His Asn Ala Tyr Gly Gly 
    770                 775                 780                 


Phe Ser Ser Thr Gln Asp Thr Val Val Ala Leu Gln Ala Leu Ala Lys 
785                 790                 795                 800 


Tyr Ala Thr Thr Ala Tyr Met Pro Ser Glu Glu Ile Asn Leu Val Val 
                805                 810                 815     


Lys Ser Thr Glu Asn Phe Gln Arg Thr Phe Asn Ile Gln Ser Val Asn 
            820                 825                 830         


Arg Leu Val Phe Gln Gln Asp Thr Leu Pro Asn Val Pro Gly Met Tyr 
        835                 840                 845             


Thr Leu Glu Ala Ser Gly Gln Gly Cys Val Tyr Val Gln Thr Val Leu 
    850                 855                 860                 


Arg Tyr Asn Ile Leu Pro Pro Thr Asn Met Lys Thr Phe Ser Leu Ser 
865                 870                 875                 880 


Val Glu Ile Gly Lys Ala Arg Cys Glu Gln Pro Thr Ser Pro Arg Ser 
                885                 890                 895     


Leu Thr Leu Thr Ile His Thr Ser Tyr Val Gly Ser Arg Ser Ser Ser 
            900                 905                 910         


Asn Met Ala Ile Val Glu Val Lys Met Leu Ser Gly Phe Ser Pro Met 
        915                 920                 925             


Glu Gly Thr Asn Gln Leu Leu Leu Gln Gln Pro Leu Val Lys Lys Val 
    930                 935                 940                 


Glu Phe Gly Thr Asp Thr Leu Asn Ile Tyr Leu Asp Glu Leu Ile Lys 
945                 950                 955                 960 


Asn Thr Gln Thr Tyr Thr Phe Thr Ile Ser Gln Ser Val Leu Val Thr 
                965                 970                 975     


Asn Leu Lys Pro Ala Thr Ile Lys Val Tyr Asp Tyr Tyr Leu Pro Asp 
            980                 985                 990         


Glu Gln Ala Thr Ile Gln Tyr Ser  Asp Pro Cys Glu 
        995                 1000                 


<210>  12
<211>  182
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  12

Xaa Arg Thr Phe Asn Ile Gln Ser Val Asn Arg Leu Val Phe Gln Gln 
1               5                   10                  15      


Asp Thr Leu Pro Asn Val Pro Gly Met Tyr Thr Leu Glu Ala Ser Gly 
            20                  25                  30          


Gln Gly Cys Val Tyr Val Gln Thr Val Leu Arg Tyr Asn Ile Leu Pro 
        35                  40                  45              


Pro Thr Asn Met Lys Thr Phe Ser Leu Ser Val Glu Ile Gly Lys Ala 
    50                  55                  60                  


Arg Cys Glu Gln Pro Thr Ser Pro Arg Ser Leu Thr Leu Thr Ile His 
65                  70                  75                  80  


Thr Ser Tyr Val Gly Ser Arg Ser Ser Ser Asn Met Ala Ile Val Glu 
                85                  90                  95      


Val Lys Met Leu Ser Gly Phe Ser Pro Met Glu Gly Thr Asn Gln Leu 
            100                 105                 110         


Leu Leu Gln Gln Pro Leu Val Lys Lys Val Glu Phe Gly Thr Asp Thr 
        115                 120                 125             


Leu Asn Ile Tyr Leu Asp Glu Leu Ile Lys Asn Thr Gln Thr Tyr Thr 
    130                 135                 140                 


Phe Thr Ile Ser Gln Ser Val Leu Val Thr Asn Leu Lys Pro Ala Thr 
145                 150                 155                 160 


Ile Lys Val Tyr Asp Tyr Tyr Leu Pro Asp Glu Gln Ala Thr Ile Gln 
                165                 170                 175     


Tyr Ser Asp Pro Cys Glu 
            180         


<210>  13
<211>  340
<212>  PRT
<213>  Homo Sapiens

<400>  13

Met Arg Lys Glu Leu Gln Leu Ser Leu Ser Val Thr Leu Leu Leu Val 
1               5                   10                  15      


Cys Gly Phe Leu Tyr Gln Phe Thr Leu Lys Ser Ser Cys Leu Phe Cys 
            20                  25                  30          


Leu Pro Ser Phe Lys Ser His Gln Gly Leu Glu Ala Leu Leu Ser His 
        35                  40                  45              


Arg Arg Gly Ile Val Phe Leu Glu Thr Ser Glu Arg Met Glu Pro Pro 
    50                  55                  60                  


His Leu Val Ser Cys Ser Val Glu Ser Ala Ala Lys Ile Tyr Pro Glu 
65                  70                  75                  80  


Trp Pro Val Val Phe Phe Met Lys Gly Leu Thr Asp Ser Thr Pro Met 
                85                  90                  95      


Pro Ser Asn Ser Thr Tyr Pro Ala Phe Ser Phe Leu Ser Ala Ile Asp 
            100                 105                 110         


Asn Val Phe Leu Phe Pro Leu Asp Met Lys Arg Leu Leu Glu Asp Thr 
        115                 120                 125             


Pro Leu Phe Ser Trp Tyr Asn Gln Ile Asn Ala Ser Ala Glu Arg Asn 
    130                 135                 140                 


Trp Leu His Ile Ser Ser Asp Ala Ser Arg Leu Ala Ile Ile Trp Lys 
145                 150                 155                 160 


Tyr Gly Gly Ile Tyr Met Asp Thr Asp Val Ile Ser Ile Arg Pro Ile 
                165                 170                 175     


Pro Glu Glu Asn Phe Leu Ala Ala Gln Ala Ser Arg Tyr Ser Ser Asn 
            180                 185                 190         


Gly Ile Phe Gly Phe Leu Pro His His Pro Phe Leu Trp Glu Cys Met 
        195                 200                 205             


Glu Asn Phe Val Glu His Tyr Asn Ser Ala Ile Trp Gly Asn Gln Gly 
    210                 215                 220                 


Pro Glu Leu Met Thr Arg Met Leu Arg Val Trp Cys Lys Leu Glu Asp 
225                 230                 235                 240 


Phe Gln Glu Val Ser Asp Leu Arg Cys Leu Asn Ile Ser Phe Leu His 
                245                 250                 255     


Pro Gln Arg Phe Tyr Pro Ile Ser Tyr Arg Glu Trp Arg Arg Tyr Tyr 
            260                 265                 270         


Glu Val Trp Asp Thr Glu Pro Ser Phe Asn Val Ser Tyr Ala Leu His 
        275                 280                 285             


Leu Trp Asn His Met Asn Gln Glu Gly Arg Ala Val Ile Arg Gly Ser 
    290                 295                 300                 


Asn Thr Leu Val Glu Asn Leu Tyr Arg Lys His Cys Pro Arg Thr Tyr 
305                 310                 315                 320 


Arg Asp Leu Ile Lys Gly Pro Glu Gly Ser Val Thr Gly Glu Leu Gly 
                325                 330                 335     


Pro Gly Asn Lys 
            340 


<210>  14
<211>  401
<212>  PRT
<213>  Homo Sapiens

<400>  14

Met Gly Leu Lys Ala Leu Cys Leu Gly Leu Leu Cys Val Leu Phe Val 
1               5                   10                  15      


Ser His Phe Tyr Thr Pro Met Pro Asp Asn Ile Glu Glu Ser Trp Lys 
            20                  25                  30          


Ile Met Ala Leu Asp Ala Ile Ala Lys Thr Cys Thr Phe Thr Ala Met 
        35                  40                  45              


Cys Phe Glu Asn Met Arg Ile Met Arg Tyr Glu Glu Phe Ile Ser Met 
    50                  55                  60                  


Ile Phe Arg Leu Asp Tyr Thr Gln Pro Leu Ser Asp Glu Tyr Ile Thr 
65                  70                  75                  80  


Val Thr Asp Thr Thr Phe Val Asp Ile Pro Val Arg Leu Tyr Leu Pro 
                85                  90                  95      


Lys Arg Lys Ser Glu Thr Arg Arg Arg Ala Val Ile Tyr Phe His Gly 
            100                 105                 110         


Gly Gly Phe Cys Phe Gly Ser Ser Lys Gln Arg Ala Phe Asp Phe Leu 
        115                 120                 125             


Asn Arg Trp Thr Ala Asn Thr Leu Asp Ala Val Val Val Gly Val Asp 
    130                 135                 140                 


Tyr Arg Leu Ala Pro Gln His His Phe Pro Ala Gln Phe Glu Asp Gly 
145                 150                 155                 160 


Leu Ala Ala Val Lys Phe Phe Leu Leu Glu Lys Ile Leu Thr Lys Tyr 
                165                 170                 175     


Gly Val Asp Pro Thr Arg Ile Cys Ile Ala Gly Asp Ser Ser Gly Gly 
            180                 185                 190         


Asn Leu Ala Thr Ala Val Thr Gln Gln Val Gln Asn Asp Ala Glu Ile 
        195                 200                 205             


Lys His Lys Ile Lys Met Gln Val Leu Leu Tyr Pro Gly Leu Gln Ile 
    210                 215                 220                 


Thr Asp Ser Tyr Leu Pro Ser His Arg Glu Asn Glu His Gly Ile Val 
225                 230                 235                 240 


Leu Thr Arg Asp Val Ala Ile Lys Leu Val Ser Leu Tyr Phe Thr Lys 
                245                 250                 255     


Asp Glu Ala Leu Pro Trp Ala Met Arg Arg Asn Gln His Met Pro Leu 
            260                 265                 270         


Glu Ser Arg His Leu Phe Lys Phe Val Asn Trp Ser Ile Leu Leu Pro 
        275                 280                 285             


Glu Lys Tyr Arg Lys Asp Tyr Val Tyr Thr Glu Pro Ile Leu Gly Gly 
    290                 295                 300                 


Leu Ser Tyr Ser Leu Pro Gly Leu Thr Asp Ser Arg Ala Leu Pro Leu 
305                 310                 315                 320 


Leu Ala Asn Asp Ser Gln Leu Gln Asn Leu Pro Leu Thr Tyr Ile Leu 
                325                 330                 335     


Thr Cys Gln His Asp Leu Leu Arg Asp Asp Gly Leu Met Tyr Val Thr 
            340                 345                 350         


Arg Leu Arg Asn Val Gly Val Gln Val Val His Glu His Ile Glu Asp 
        355                 360                 365             


Gly Ile His Gly Ala Leu Ser Phe Met Thr Ser Pro Phe Tyr Leu Arg 
    370                 375                 380                 


Leu Gly Leu Arg Ile Arg Asp Met Tyr Val Ser Trp Leu Asp Lys Asn 
385                 390                 395                 400 


Leu 
    


<210>  15
<211>  53
<212>  PRT
<213>  Homo Sapiens

<400>  15

Met Gly Leu Lys Ala Leu Cys Leu Gly Leu Leu Cys Val Leu Phe Val 
1               5                   10                  15      


Ser His Phe Tyr Thr Pro Met Pro Asp Asn Ile Glu Glu Ser Trp Lys 
            20                  25                  30          


Ile Met Ala Leu Asp Ala Ile Ala Lys Thr Cys Thr Phe Thr Asn Arg 
        35                  40                  45              


Gly Leu Leu Thr Ser 
    50              


<210>  16
<211>  252
<212>  PRT
<213>  Homo Sapiens

<400>  16

Met Glu Pro Gln Ser Met Lys Gly Gln Lys Arg Pro Phe Gly Gly Pro 
1               5                   10                  15      


Trp Arg Leu Lys Val Leu Gly Gly Pro Pro Trp Leu Arg Arg Thr Leu 
            20                  25                  30          


Pro Lys Leu Gly Arg Pro Lys Glu Ala Pro Val Ala Arg Met Ser Thr 
        35                  40                  45              


Gln Ser Thr His Pro Leu Lys Pro Glu Ala Pro Arg Leu Pro Pro Gly 
    50                  55                  60                  


Ile Pro Glu Ser Pro Ser Cys Gln Arg Arg His Thr Leu Pro Ala Ser 
65                  70                  75                  80  


Glu Phe Arg Cys Leu Thr Pro Glu Asp Ala Val Ser Ala Phe Glu Ile 
                85                  90                  95      


Glu Arg Glu Ala Phe Ile Ser Val Leu Gly Val Cys Pro Leu Tyr Leu 
            100                 105                 110         


Asp Glu Ile Arg His Phe Leu Thr Leu Cys Pro Glu Leu Ser Leu Gly 
        115                 120                 125             


Trp Phe Glu Glu Gly Cys Leu Val Ala Phe Ile Ile Gly Ser Leu Trp 
    130                 135                 140                 


Asp Lys Glu Arg Leu Met Gln Glu Ser Leu Thr Leu His Arg Ser Gly 
145                 150                 155                 160 


Gly His Ile Ala His Leu His Val Leu Ala Val His Arg Ala Phe Arg 
                165                 170                 175     


Gln Gln Gly Arg Gly Pro Ile Leu Leu Trp Arg Tyr Leu His His Leu 
            180                 185                 190         


Gly Ser Gln Pro Ala Val Arg Arg Ala Ala Leu Met Cys Glu Asp Ala 
        195                 200                 205             


Leu Val Pro Phe Tyr Glu Arg Phe Ser Phe His Ala Val Gly Pro Cys 
    210                 215                 220                 


Ala Ile Thr Val Gly Ser Leu Thr Phe Met Glu Leu His Cys Ser Leu 
225                 230                 235                 240 


Arg Gly His Pro Phe Leu Arg Arg Asn Ser Gly Cys 
                245                 250         


<210>  17
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  17

Met Arg Met Arg Pro Leu Ser Leu Ala Val Leu Gln Gln Val Leu Gly 
1               5                   10                  15      


Gly Pro Pro Trp Leu Arg Arg Thr Leu Pro Lys Leu Gly Arg Pro Lys 
            20                  25                  30          


Glu Ala Pro Val Ala Arg Met Ser Thr Gln Ser Thr His Pro Leu Lys 
        35                  40                  45              


Pro Glu Ala Pro Arg Leu Pro Pro Gly Ile Pro Glu Ser Pro Ser Cys 
    50                  55                  60                  


Gln Arg Arg His Thr Leu Pro Ala Ser Glu Phe Arg Cys Leu Thr Pro 
65                  70                  75                  80  


Glu Asp Ala Val Ser Ala Phe Glu Ile Glu Arg Glu Ala Phe Ile Ser 
                85                  90                  95      


Val Leu Gly Val Cys Pro Leu Tyr Leu Asp Glu Ile Arg His Phe Leu 
            100                 105                 110         


Thr Leu Cys Pro Glu Leu Ser Leu Gly Trp Phe Glu Glu Gly Cys Leu 
        115                 120                 125             


Val Ala Phe Ile Ile Gly Ser Leu Trp Asp Lys Glu Arg Leu Met Gln 
    130                 135                 140                 


Glu Ser Leu Thr Leu His Arg Ser 
145                 150         


<210>  18
<211>  207
<212>  PRT
<213>  Homo Sapiens

<400>  18

Met Ser Thr Gln Ser Thr His Pro Leu Lys Pro Glu Ala Pro Arg Leu 
1               5                   10                  15      


Pro Pro Gly Ile Pro Glu Ser Pro Ser Cys Gln Arg Arg His Thr Leu 
            20                  25                  30          


Pro Ala Ser Glu Phe Arg Cys Leu Thr Pro Glu Asp Ala Val Ser Ala 
        35                  40                  45              


Phe Glu Ile Glu Arg Glu Ala Phe Ile Ser Val Leu Gly Val Cys Pro 
    50                  55                  60                  


Leu Tyr Leu Asp Glu Ile Arg His Phe Leu Thr Leu Cys Pro Glu Leu 
65                  70                  75                  80  


Ser Leu Gly Trp Phe Glu Glu Gly Cys Leu Val Ala Phe Ile Ile Gly 
                85                  90                  95      


Ser Leu Trp Asp Lys Glu Arg Leu Met Gln Glu Ser Leu Thr Leu His 
            100                 105                 110         


Arg Ser Gly Gly His Ile Ala His Leu His Val Leu Ala Val His Arg 
        115                 120                 125             


Ala Phe Arg Gln Gln Gly Arg Gly Pro Ile Leu Leu Trp Arg Tyr Leu 
    130                 135                 140                 


His His Leu Gly Ser Gln Pro Ala Val Arg Arg Ala Ala Leu Met Cys 
145                 150                 155                 160 


Glu Asp Ala Leu Val Pro Phe Tyr Glu Arg Phe Ser Phe His Ala Val 
                165                 170                 175     


Gly Pro Cys Ala Ile Thr Val Gly Ser Leu Thr Phe Met Glu Leu His 
            180                 185                 190         


Cys Ser Leu Arg Gly His Pro Phe Leu Arg Arg Asn Ser Gly Cys 
        195                 200                 205         


<210>  19
<211>  92
<212>  PRT
<213>  Homo Sapiens

<400>  19

Met Ser Thr Gln Ser Thr His Pro Leu Lys Pro Glu Ala Pro Arg Leu 
1               5                   10                  15      


Pro Pro Gly Ile Pro Glu Ser Pro Ser Cys Gln Arg Arg His Thr Leu 
            20                  25                  30          


Pro Ala Ser Glu Phe Arg Cys Leu Thr Pro Glu Asp Ala Val Ser Ala 
        35                  40                  45              


Phe Glu Ile Glu Arg Glu Asp Ser Gly Arg Glu Ala Gln Arg Leu Pro 
    50                  55                  60                  


Val Thr His Leu Ser Leu Leu Pro Gln Pro Ser Ser Pro Ser Trp Ala 
65                  70                  75                  80  


Ser Ala Pro Cys Thr Trp Met Arg Ser Gly Thr Ser 
                85                  90          


<210>  20
<211>  257
<212>  PRT
<213>  Homo Sapiens

<400>  20

Met Ala Cys Leu Met Ala Ala Phe Ser Val Gly Thr Ala Met Asn Ala 
1               5                   10                  15      


Ser Ser Tyr Ser Ala Glu Met Thr Glu Pro Lys Ser Val Cys Val Ser 
            20                  25                  30          


Val Asp Glu Val Val Ser Ser Asn Met Glu Ala Thr Glu Thr Asp Leu 
        35                  40                  45              


Leu Asn Gly His Leu Lys Lys Val Asp Asn Asn Leu Thr Glu Ala Gln 
    50                  55                  60                  


Arg Phe Ser Ser Leu Pro Arg Arg Ala Ala Val Asn Ile Glu Phe Arg 
65                  70                  75                  80  


Asp Leu Ser Tyr Ser Val Pro Glu Gly Pro Trp Trp Arg Lys Lys Gly 
                85                  90                  95      


Tyr Lys Thr Leu Leu Lys Gly Ile Ser Gly Lys Phe Asn Ser Gly Glu 
            100                 105                 110         


Leu Val Ala Ile Met Gly Pro Ser Gly Ala Gly Lys Ser Thr Leu Met 
        115                 120                 125             


Asn Ile Leu Ala Gly Tyr Arg Glu Thr Gly Met Lys Gly Ala Val Leu 
    130                 135                 140                 


Ile Asn Gly Leu Pro Arg Asp Leu Arg Cys Phe Arg Lys Val Ser Cys 
145                 150                 155                 160 


Tyr Ile Met Gln Asp Asp Met Leu Leu Pro His Leu Thr Val Gln Glu 
                165                 170                 175     


Ala Met Met Val Lys Glu Ile Leu Thr Ala Leu Gly Leu Leu Ser Cys 
            180                 185                 190         


Ala Asn Thr Arg Thr Gly Ser Leu Ser Gly Gly Gln Arg Lys Arg Leu 
        195                 200                 205             


Ala Ile Ala Leu Glu Leu Val Asn Asn Pro Pro Val Met Phe Phe Asp 
    210                 215                 220                 


Glu Pro Thr Ser Gly Leu Asp Ser Ala Ser Cys Phe Gln Val Val Ser 
225                 230                 235                 240 


Leu Met Lys Gly Leu Ala Gln Gly Gly Arg Ser Ile Ile Cys Thr Ile 
                245                 250                 255     


His 
    


<210>  21
<211>  678
<212>  PRT
<213>  Homo Sapiens

<400>  21

Met Ala Cys Leu Met Ala Ala Phe Ser Val Gly Thr Ala Met Asn Ala 
1               5                   10                  15      


Ser Ser Tyr Ser Ala Glu Met Thr Glu Pro Lys Ser Val Cys Val Ser 
            20                  25                  30          


Val Asp Glu Val Val Ser Ser Asn Met Glu Ala Thr Glu Thr Asp Leu 
        35                  40                  45              


Leu Asn Gly His Leu Lys Lys Val Asp Asn Asn Leu Thr Glu Ala Gln 
    50                  55                  60                  


Arg Phe Ser Ser Leu Pro Arg Arg Ala Ala Val Asn Ile Glu Phe Arg 
65                  70                  75                  80  


Asp Leu Ser Tyr Ser Val Pro Glu Gly Pro Trp Trp Arg Lys Lys Gly 
                85                  90                  95      


Tyr Lys Thr Leu Leu Lys Gly Ile Ser Gly Lys Phe Asn Ser Gly Glu 
            100                 105                 110         


Leu Val Ala Ile Met Gly Pro Ser Gly Ala Gly Lys Ser Thr Leu Met 
        115                 120                 125             


Asn Ile Leu Ala Gly Tyr Arg Glu Thr Gly Met Lys Gly Ala Val Leu 
    130                 135                 140                 


Ile Asn Gly Leu Pro Arg Asp Leu Arg Cys Phe Arg Lys Val Ser Cys 
145                 150                 155                 160 


Tyr Ile Met Gln Asp Asp Met Leu Leu Pro His Leu Thr Val Gln Glu 
                165                 170                 175     


Ala Met Met Val Ser Ala His Leu Lys Leu Gln Glu Lys Asp Glu Gly 
            180                 185                 190         


Arg Arg Glu Met Val Lys Glu Ile Leu Thr Ala Leu Gly Leu Leu Ser 
        195                 200                 205             


Cys Ala Asn Thr Arg Thr Gly Ser Leu Ser Gly Gly Gln Arg Lys Arg 
    210                 215                 220                 


Leu Ala Ile Ala Leu Glu Leu Val Asn Asn Pro Pro Val Met Phe Phe 
225                 230                 235                 240 


Asp Glu Pro Thr Ser Gly Leu Asp Ser Ala Ser Cys Phe Gln Val Val 
                245                 250                 255     


Ser Leu Met Lys Gly Leu Ala Gln Gly Gly Arg Ser Ile Ile Cys Thr 
            260                 265                 270         


Ile His Gln Pro Ser Ala Lys Leu Phe Glu Leu Phe Asp Gln Leu Tyr 
        275                 280                 285             


Val Leu Ser Gln Gly Gln Cys Val Tyr Arg Gly Lys Val Cys Asn Leu 
    290                 295                 300                 


Val Pro Tyr Leu Arg Asp Leu Gly Leu Asn Cys Pro Thr Tyr His Asn 
305                 310                 315                 320 


Pro Ala Asp Phe Val Met Glu Val Ala Ser Gly Glu Tyr Gly Asp Gln 
                325                 330                 335     


Asn Ser Arg Leu Val Arg Ala Val Arg Glu Gly Met Cys Asp Ser Asp 
            340                 345                 350         


His Lys Arg Asp Leu Gly Gly Asp Ala Glu Val Asn Pro Phe Leu Trp 
        355                 360                 365             


His Arg Pro Ser Glu Glu Val Lys Gln Thr Lys Arg Leu Lys Gly Leu 
    370                 375                 380                 


Arg Lys Asp Ser Ser Ser Met Glu Gly Cys His Ser Phe Ser Ala Ser 
385                 390                 395                 400 


Cys Leu Thr Gln Phe Cys Ile Leu Phe Lys Arg Thr Phe Leu Ser Ile 
                405                 410                 415     


Met Arg Asp Ser Val Leu Thr His Leu Arg Ile Thr Ser His Ile Gly 
            420                 425                 430         


Ile Gly Leu Leu Ile Gly Leu Leu Tyr Leu Gly Ile Gly Asn Glu Ala 
        435                 440                 445             


Lys Lys Val Leu Ser Asn Ser Gly Phe Leu Phe Phe Ser Met Leu Phe 
    450                 455                 460                 


Leu Met Phe Ala Ala Leu Met Pro Thr Val Leu Thr Phe Pro Leu Glu 
465                 470                 475                 480 


Met Gly Val Phe Leu Arg Glu His Leu Asn Tyr Trp Tyr Ser Leu Lys 
                485                 490                 495     


Ala Tyr Tyr Leu Ala Lys Thr Met Ala Asp Val Pro Phe Gln Ile Met 
            500                 505                 510         


Phe Pro Val Ala Tyr Cys Ser Ile Val Tyr Trp Met Thr Ser Gln Pro 
        515                 520                 525             


Ser Asp Ala Val Arg Phe Val Leu Phe Ala Ala Leu Gly Thr Met Thr 
    530                 535                 540                 


Ser Leu Val Ala Gln Ser Leu Gly Leu Leu Ile Gly Ala Ala Ser Thr 
545                 550                 555                 560 


Ser Leu Gln Val Ala Thr Phe Val Gly Pro Val Thr Ala Ile Pro Val 
                565                 570                 575     


Leu Leu Phe Ser Gly Phe Phe Val Ser Phe Asp Thr Ile Pro Thr Tyr 
            580                 585                 590         


Leu Gln Trp Met Ser Tyr Ile Ser Tyr Val Arg Tyr Gly Phe Glu Gly 
        595                 600                 605             


Val Ile Leu Ser Ile Tyr Gly Leu Asp Arg Glu Asp Leu His Cys Asp 
    610                 615                 620                 


Ile Asp Glu Thr Cys His Phe Gln Lys Ser Glu Ala Ile Leu Arg Glu 
625                 630                 635                 640 


Leu Asp Val Glu Asn Ala Lys Leu Tyr Leu Asp Phe Ile Val Leu Gly 
                645                 650                 655     


Ile Phe Phe Ile Ser Leu Arg Leu Ile Ala Tyr Phe Val Leu Arg Tyr 
            660                 665                 670         


Lys Ile Arg Ala Glu Arg 
        675             


<210>  22
<211>  666
<212>  PRT
<213>  Homo Sapiens

<400>  22

Met Ala Cys Leu Met Ala Ala Phe Ser Val Gly Thr Ala Met Asn Ala 
1               5                   10                  15      


Ser Ser Tyr Ser Ala Glu Met Thr Glu Pro Lys Ser Val Cys Val Ser 
            20                  25                  30          


Val Asp Glu Val Val Ser Ser Asn Met Glu Ala Thr Glu Thr Asp Leu 
        35                  40                  45              


Leu Asn Gly His Leu Lys Lys Val Asp Asn Asn Leu Thr Glu Ala Gln 
    50                  55                  60                  


Arg Phe Ser Ser Leu Pro Arg Arg Ala Ala Val Asn Ile Glu Phe Arg 
65                  70                  75                  80  


Asp Leu Ser Tyr Ser Val Pro Glu Gly Pro Trp Trp Arg Lys Lys Gly 
                85                  90                  95      


Tyr Lys Thr Leu Leu Lys Gly Ile Ser Gly Lys Phe Asn Ser Gly Glu 
            100                 105                 110         


Leu Val Ala Ile Met Gly Pro Ser Gly Ala Gly Lys Ser Thr Leu Met 
        115                 120                 125             


Asn Ile Leu Ala Gly Tyr Arg Glu Thr Gly Met Lys Gly Ala Val Leu 
    130                 135                 140                 


Ile Asn Gly Leu Pro Arg Asp Leu Arg Cys Phe Arg Lys Val Ser Cys 
145                 150                 155                 160 


Tyr Ile Met Gln Asp Asp Met Leu Leu Pro His Leu Thr Val Gln Glu 
                165                 170                 175     


Ala Met Met Val Ser Ala His Leu Lys Leu Gln Glu Lys Asp Glu Gly 
            180                 185                 190         


Arg Arg Glu Met Val Lys Glu Ile Leu Thr Ala Leu Gly Leu Leu Ser 
        195                 200                 205             


Cys Ala Asn Thr Arg Thr Gly Ser Leu Ser Gly Gly Gln Arg Lys Arg 
    210                 215                 220                 


Leu Ala Ile Ala Leu Glu Leu Val Asn Asn Pro Pro Val Met Phe Phe 
225                 230                 235                 240 


Asp Glu Pro Thr Ser Gly Leu Asp Ser Ala Ser Cys Phe Gln Val Val 
                245                 250                 255     


Ser Leu Met Lys Gly Leu Ala Gln Gly Gly Arg Ser Ile Ile Cys Thr 
            260                 265                 270         


Ile His Gln Pro Ser Ala Lys Leu Phe Glu Leu Phe Asp Gln Leu Tyr 
        275                 280                 285             


Val Leu Ser Gln Gly Gln Cys Val Tyr Arg Gly Lys Val Cys Asn Leu 
    290                 295                 300                 


Val Pro Tyr Leu Arg Asp Leu Gly Leu Asn Cys Pro Thr Tyr His Asn 
305                 310                 315                 320 


Pro Ala Asp Phe Val Met Glu Val Ala Ser Gly Glu Tyr Gly Asp Gln 
                325                 330                 335     


Asn Ser Arg Leu Val Arg Ala Val Arg Glu Gly Met Cys Asp Ser Asp 
            340                 345                 350         


His Lys Arg Asp Leu Gly Gly Asp Ala Glu Val Asn Pro Phe Leu Trp 
        355                 360                 365             


His Arg Pro Ser Glu Glu Asp Ser Ser Ser Met Glu Gly Cys His Ser 
    370                 375                 380                 


Phe Ser Ala Ser Cys Leu Thr Gln Phe Cys Ile Leu Phe Lys Arg Thr 
385                 390                 395                 400 


Phe Leu Ser Ile Met Arg Asp Ser Val Leu Thr His Leu Arg Ile Thr 
                405                 410                 415     


Ser His Ile Gly Ile Gly Leu Leu Ile Gly Leu Leu Tyr Leu Gly Ile 
            420                 425                 430         


Gly Asn Glu Ala Lys Lys Val Leu Ser Asn Ser Gly Phe Leu Phe Phe 
        435                 440                 445             


Ser Met Leu Phe Leu Met Phe Ala Ala Leu Met Pro Thr Val Leu Thr 
    450                 455                 460                 


Phe Pro Leu Glu Met Gly Val Phe Leu Arg Glu His Leu Asn Tyr Trp 
465                 470                 475                 480 


Tyr Ser Leu Lys Ala Tyr Tyr Leu Ala Lys Thr Met Ala Asp Val Pro 
                485                 490                 495     


Phe Gln Ile Met Phe Pro Val Ala Tyr Cys Ser Ile Val Tyr Trp Met 
            500                 505                 510         


Thr Ser Gln Pro Ser Asp Ala Val Arg Phe Val Leu Phe Ala Ala Leu 
        515                 520                 525             


Gly Thr Met Thr Ser Leu Val Ala Gln Ser Leu Gly Leu Leu Ile Gly 
    530                 535                 540                 


Ala Ala Ser Thr Ser Leu Gln Val Ala Thr Phe Val Gly Pro Val Thr 
545                 550                 555                 560 


Ala Ile Pro Val Leu Leu Phe Ser Gly Phe Phe Val Ser Phe Asp Thr 
                565                 570                 575     


Ile Pro Thr Tyr Leu Gln Trp Met Ser Tyr Ile Ser Tyr Val Arg Tyr 
            580                 585                 590         


Gly Phe Glu Gly Val Ile Leu Ser Ile Tyr Gly Leu Asp Arg Glu Asp 
        595                 600                 605             


Leu His Cys Asp Ile Asp Glu Thr Cys His Phe Gln Lys Ser Glu Ala 
    610                 615                 620                 


Ile Leu Arg Glu Leu Asp Val Glu Asn Ala Lys Leu Tyr Leu Asp Phe 
625                 630                 635                 640 


Ile Val Leu Gly Ile Phe Phe Ile Ser Leu Arg Leu Ile Ala Tyr Phe 
                645                 650                 655     


Val Leu Arg Tyr Lys Ile Arg Ala Glu Arg 
            660                 665     


<210>  23
<211>  663
<212>  PRT
<213>  Homo Sapiens

<400>  23

Met Ile Met Arg Leu Pro Gln Pro His Gly Thr Asn Ala Ser Ser Tyr 
1               5                   10                  15      


Ser Ala Glu Met Thr Glu Pro Lys Ser Val Cys Val Ser Val Asp Glu 
            20                  25                  30          


Val Val Ser Ser Asn Met Glu Ala Thr Glu Thr Asp Leu Leu Asn Gly 
        35                  40                  45              


His Leu Lys Lys Val Asp Asn Asn Leu Thr Glu Ala Gln Arg Phe Ser 
    50                  55                  60                  


Ser Leu Pro Arg Arg Ala Ala Val Asn Ile Glu Phe Arg Asp Leu Ser 
65                  70                  75                  80  


Tyr Ser Val Pro Glu Gly Pro Trp Trp Arg Lys Lys Gly Tyr Lys Thr 
                85                  90                  95      


Leu Leu Lys Gly Ile Ser Gly Lys Phe Asn Ser Gly Glu Leu Val Ala 
            100                 105                 110         


Ile Met Gly Pro Ser Gly Ala Gly Lys Ser Thr Leu Met Asn Ile Leu 
        115                 120                 125             


Ala Gly Tyr Arg Glu Thr Gly Met Lys Gly Ala Val Leu Ile Asn Gly 
    130                 135                 140                 


Leu Pro Arg Asp Leu Arg Cys Phe Arg Lys Val Ser Cys Tyr Ile Met 
145                 150                 155                 160 


Gln Asp Asp Met Leu Leu Pro His Leu Thr Val Gln Glu Ala Met Met 
                165                 170                 175     


Val Ser Ala His Leu Lys Leu Gln Glu Lys Asp Glu Gly Arg Arg Glu 
            180                 185                 190         


Met Val Lys Glu Ile Leu Thr Ala Leu Gly Leu Leu Ser Cys Ala Asn 
        195                 200                 205             


Thr Arg Thr Gly Ser Leu Ser Gly Gly Gln Arg Lys Arg Leu Ala Ile 
    210                 215                 220                 


Ala Leu Glu Leu Val Asn Asn Pro Pro Val Met Phe Phe Asp Glu Pro 
225                 230                 235                 240 


Thr Ser Gly Leu Asp Ser Ala Ser Cys Phe Gln Val Val Ser Leu Met 
                245                 250                 255     


Lys Gly Leu Ala Gln Gly Gly Arg Ser Ile Ile Cys Thr Ile His Gln 
            260                 265                 270         


Pro Ser Ala Lys Leu Phe Glu Leu Phe Asp Gln Leu Tyr Val Leu Ser 
        275                 280                 285             


Gln Gly Gln Cys Val Tyr Arg Gly Lys Val Cys Asn Leu Val Pro Tyr 
    290                 295                 300                 


Leu Arg Asp Leu Gly Leu Asn Cys Pro Thr Tyr His Asn Pro Ala Asp 
305                 310                 315                 320 


Phe Val Met Glu Val Ala Ser Gly Glu Tyr Gly Asp Gln Asn Ser Arg 
                325                 330                 335     


Leu Val Arg Ala Val Arg Glu Gly Met Cys Asp Ser Asp His Lys Arg 
            340                 345                 350         


Asp Leu Gly Gly Asp Ala Glu Val Asn Pro Phe Leu Trp His Arg Pro 
        355                 360                 365             


Ser Glu Glu Asp Ser Ser Ser Met Glu Gly Cys His Ser Phe Ser Ala 
    370                 375                 380                 


Ser Cys Leu Thr Gln Phe Cys Ile Leu Phe Lys Arg Thr Phe Leu Ser 
385                 390                 395                 400 


Ile Met Arg Asp Ser Val Leu Thr His Leu Arg Ile Thr Ser His Ile 
                405                 410                 415     


Gly Ile Gly Leu Leu Ile Gly Leu Leu Tyr Leu Gly Ile Gly Asn Glu 
            420                 425                 430         


Ala Lys Lys Val Leu Ser Asn Ser Gly Phe Leu Phe Phe Ser Met Leu 
        435                 440                 445             


Phe Leu Met Phe Ala Ala Leu Met Pro Thr Val Leu Thr Phe Pro Leu 
    450                 455                 460                 


Glu Met Gly Val Phe Leu Arg Glu His Leu Asn Tyr Trp Tyr Ser Leu 
465                 470                 475                 480 


Lys Ala Tyr Tyr Leu Ala Lys Thr Met Ala Asp Val Pro Phe Gln Ile 
                485                 490                 495     


Met Phe Pro Val Ala Tyr Cys Ser Ile Val Tyr Trp Met Thr Ser Gln 
            500                 505                 510         


Pro Ser Asp Ala Val Arg Phe Val Leu Phe Ala Ala Leu Gly Thr Met 
        515                 520                 525             


Thr Ser Leu Val Ala Gln Ser Leu Gly Leu Leu Ile Gly Ala Ala Ser 
    530                 535                 540                 


Thr Ser Leu Gln Val Ala Thr Phe Val Gly Pro Val Thr Ala Ile Pro 
545                 550                 555                 560 


Val Leu Leu Phe Ser Gly Phe Phe Val Ser Phe Asp Thr Ile Pro Thr 
                565                 570                 575     


Tyr Leu Gln Trp Met Ser Tyr Ile Ser Tyr Val Arg Tyr Gly Phe Glu 
            580                 585                 590         


Gly Val Ile Leu Ser Ile Tyr Gly Leu Asp Arg Glu Asp Leu His Cys 
        595                 600                 605             


Asp Ile Asp Glu Thr Cys His Phe Gln Lys Ser Glu Ala Ile Leu Arg 
    610                 615                 620                 


Glu Leu Asp Val Glu Asn Ala Lys Leu Tyr Leu Asp Phe Ile Val Leu 
625                 630                 635                 640 


Gly Ile Phe Phe Ile Ser Leu Arg Leu Ile Ala Tyr Phe Val Leu Arg 
                645                 650                 655     


Tyr Lys Ile Arg Ala Glu Arg 
            660             


<210>  24
<211>  824
<212>  PRT
<213>  Homo Sapiens

<400>  24

Met Leu Ala Val Gln Gln Thr Glu His Leu Pro Ala Cys Pro Pro Ala 
1               5                   10                  15      


Arg Arg Trp Ser Ser Asn Phe Cys Pro Glu Ser Thr Glu Gly Gly Pro 
            20                  25                  30          


Ser Leu Leu Gly Leu Arg Asp Met Val Arg Arg Gly Trp Ser Val Cys 
        35                  40                  45              


Thr Ala Ile Leu Leu Ala Arg Leu Trp Cys Leu Val Pro Thr His Thr 
    50                  55                  60                  


Phe Leu Ser Glu Tyr Pro Glu Ala Ala Glu Tyr Pro His Pro Gly Trp 
65                  70                  75                  80  


Val Tyr Trp Leu Gln Met Ala Val Ala Pro Gly His Leu Arg Ala Trp 
                85                  90                  95      


Val Met Arg Asn Asn Val Thr Thr Asn Ile Pro Ser Ala Phe Ser Gly 
            100                 105                 110         


Thr Leu Thr His Glu Glu Lys Ala Val Leu Thr Val Phe Thr Gly Thr 
        115                 120                 125             


Ala Thr Ala Val His Val Gln Val Ala Ala Leu Ala Ser Ala Lys Leu 
    130                 135                 140                 


Glu Ser Ser Val Phe Val Thr Asp Cys Val Ser Cys Lys Ile Glu Asn 
145                 150                 155                 160 


Val Cys Asp Ser Ala Leu Gln Gly Lys Arg Val Pro Met Ser Gly Leu 
                165                 170                 175     


Gln Gly Ser Ser Ile Val Ile Met Pro Pro Ser Asn Arg Pro Leu Ala 
            180                 185                 190         


Ser Ala Ala Ser Cys Thr Trp Ser Val Gln Val Gln Gly Gly Pro His 
        195                 200                 205             


His Leu Gly Val Val Ala Ile Ser Gly Lys Val Leu Ser Ala Ala His 
    210                 215                 220                 


Gly Ala Gly Arg Ala Tyr Gly Trp Gly Phe Pro Gly Asp Pro Met Glu 
225                 230                 235                 240 


Glu Gly Tyr Lys Thr Leu Leu Lys Gly Ile Ser Gly Lys Phe Asn Ser 
                245                 250                 255     


Gly Glu Leu Val Ala Ile Met Gly Pro Ser Gly Ala Gly Lys Ser Thr 
            260                 265                 270         


Leu Met Asn Ile Leu Ala Gly Tyr Arg Glu Thr Gly Met Lys Gly Ala 
        275                 280                 285             


Val Leu Ile Asn Gly Leu Pro Arg Asp Leu Arg Cys Phe Arg Lys Val 
    290                 295                 300                 


Ser Cys Tyr Ile Met Gln Asp Asp Met Leu Leu Pro His Leu Thr Val 
305                 310                 315                 320 


Gln Glu Ala Met Met Val Ser Ala His Leu Lys Leu Gln Glu Lys Asp 
                325                 330                 335     


Glu Gly Arg Arg Glu Met Val Lys Glu Ile Leu Thr Ala Leu Gly Leu 
            340                 345                 350         


Leu Ser Cys Ala Asn Thr Arg Thr Gly Ser Leu Ser Gly Gly Gln Arg 
        355                 360                 365             


Lys Arg Leu Ala Ile Ala Leu Glu Leu Val Asn Asn Pro Pro Val Met 
    370                 375                 380                 


Phe Phe Asp Glu Pro Thr Ser Gly Leu Asp Ser Ala Ser Cys Phe Gln 
385                 390                 395                 400 


Val Val Ser Leu Met Lys Gly Leu Ala Gln Gly Gly Arg Ser Ile Ile 
                405                 410                 415     


Cys Thr Ile His Gln Pro Ser Ala Lys Leu Phe Glu Leu Phe Asp Gln 
            420                 425                 430         


Leu Tyr Val Leu Ser Gln Gly Gln Cys Val Tyr Arg Gly Lys Val Cys 
        435                 440                 445             


Asn Leu Val Pro Tyr Leu Arg Asp Leu Gly Leu Asn Cys Pro Thr Tyr 
    450                 455                 460                 


His Asn Pro Ala Asp Phe Val Met Glu Val Ala Ser Gly Glu Tyr Gly 
465                 470                 475                 480 


Asp Gln Asn Ser Arg Leu Val Arg Ala Val Arg Glu Gly Met Cys Asp 
                485                 490                 495     


Ser Asp His Lys Arg Asp Leu Gly Gly Asp Ala Glu Val Asn Pro Phe 
            500                 505                 510         


Leu Trp His Arg Pro Ser Glu Glu Val Lys Gln Thr Lys Arg Leu Lys 
        515                 520                 525             


Gly Leu Arg Lys Asp Ser Ser Ser Met Glu Gly Cys His Ser Phe Ser 
    530                 535                 540                 


Ala Ser Cys Leu Thr Gln Phe Cys Ile Leu Phe Lys Arg Thr Phe Leu 
545                 550                 555                 560 


Ser Ile Met Arg Asp Ser Val Leu Thr His Leu Arg Ile Thr Ser His 
                565                 570                 575     


Ile Gly Ile Gly Leu Leu Ile Gly Leu Leu Tyr Leu Gly Ile Gly Asn 
            580                 585                 590         


Glu Ala Lys Lys Val Leu Ser Asn Ser Gly Phe Leu Phe Phe Ser Met 
        595                 600                 605             


Leu Phe Leu Met Phe Ala Ala Leu Met Pro Thr Val Leu Thr Phe Pro 
    610                 615                 620                 


Leu Glu Met Gly Val Phe Leu Arg Glu His Leu Asn Tyr Trp Tyr Ser 
625                 630                 635                 640 


Leu Lys Ala Tyr Tyr Leu Ala Lys Thr Met Ala Asp Val Pro Phe Gln 
                645                 650                 655     


Ile Met Phe Pro Val Ala Tyr Cys Ser Ile Val Tyr Trp Met Thr Ser 
            660                 665                 670         


Gln Pro Ser Asp Ala Val Arg Phe Val Leu Phe Ala Ala Leu Gly Thr 
        675                 680                 685             


Met Thr Ser Leu Val Ala Gln Ser Leu Gly Leu Leu Ile Gly Ala Ala 
    690                 695                 700                 


Ser Thr Ser Leu Gln Val Ala Thr Phe Val Gly Pro Val Thr Ala Ile 
705                 710                 715                 720 


Pro Val Leu Leu Phe Ser Gly Phe Phe Val Ser Phe Asp Thr Ile Pro 
                725                 730                 735     


Thr Tyr Leu Gln Trp Met Ser Tyr Ile Ser Tyr Val Arg Tyr Gly Phe 
            740                 745                 750         


Glu Gly Val Ile Leu Ser Ile Tyr Gly Leu Asp Arg Glu Asp Leu His 
        755                 760                 765             


Cys Asp Ile Asp Glu Thr Cys His Phe Gln Lys Ser Glu Ala Ile Leu 
    770                 775                 780                 


Arg Glu Leu Asp Val Glu Asn Ala Lys Leu Tyr Leu Asp Phe Ile Val 
785                 790                 795                 800 


Leu Gly Ile Phe Phe Ile Ser Leu Arg Leu Ile Ala Tyr Phe Val Leu 
                805                 810                 815     


Arg Tyr Lys Ile Arg Ala Glu Arg 
            820                 


<210>  25
<211>  668
<212>  PRT
<213>  Homo Sapiens

<400>  25

Met Leu Gly Thr Gln Gly Trp Thr Lys Gln Arg Lys Pro Cys Pro Gln 
1               5                   10                  15      


Asn Ala Ser Ser Tyr Ser Ala Glu Met Thr Glu Pro Lys Ser Val Cys 
            20                  25                  30          


Val Ser Val Asp Glu Val Val Ser Ser Asn Met Glu Ala Thr Glu Thr 
        35                  40                  45              


Asp Leu Leu Asn Gly His Leu Lys Lys Val Asp Asn Asn Leu Thr Glu 
    50                  55                  60                  


Ala Gln Arg Phe Ser Ser Leu Pro Arg Arg Ala Ala Val Asn Ile Glu 
65                  70                  75                  80  


Phe Arg Asp Leu Ser Tyr Ser Val Pro Glu Gly Pro Trp Trp Arg Lys 
                85                  90                  95      


Lys Gly Tyr Lys Thr Leu Leu Lys Gly Ile Ser Gly Lys Phe Asn Ser 
            100                 105                 110         


Gly Glu Leu Val Ala Ile Met Gly Pro Ser Gly Ala Gly Lys Ser Thr 
        115                 120                 125             


Leu Met Asn Ile Leu Ala Gly Tyr Arg Glu Thr Gly Met Lys Gly Ala 
    130                 135                 140                 


Val Leu Ile Asn Gly Leu Pro Arg Asp Leu Arg Cys Phe Arg Lys Val 
145                 150                 155                 160 


Ser Cys Tyr Ile Met Gln Asp Asp Met Leu Leu Pro His Leu Thr Val 
                165                 170                 175     


Gln Glu Ala Met Met Val Ser Ala His Leu Lys Leu Gln Glu Lys Asp 
            180                 185                 190         


Glu Gly Arg Arg Glu Met Val Lys Glu Ile Leu Thr Ala Leu Gly Leu 
        195                 200                 205             


Leu Ser Cys Ala Asn Thr Arg Thr Gly Ser Leu Ser Gly Gly Gln Arg 
    210                 215                 220                 


Lys Arg Leu Ala Ile Ala Leu Glu Leu Val Asn Asn Pro Pro Val Met 
225                 230                 235                 240 


Phe Phe Asp Glu Pro Thr Ser Gly Leu Asp Ser Ala Ser Cys Phe Gln 
                245                 250                 255     


Val Val Ser Leu Met Lys Gly Leu Ala Gln Gly Gly Arg Ser Ile Ile 
            260                 265                 270         


Cys Thr Ile His Gln Pro Ser Ala Lys Leu Phe Glu Leu Phe Asp Gln 
        275                 280                 285             


Leu Tyr Val Leu Ser Gln Gly Gln Cys Val Tyr Arg Gly Lys Val Cys 
    290                 295                 300                 


Asn Leu Val Pro Tyr Leu Arg Asp Leu Gly Leu Asn Cys Pro Thr Tyr 
305                 310                 315                 320 


His Asn Pro Ala Asp Phe Val Met Glu Val Ala Ser Gly Glu Tyr Gly 
                325                 330                 335     


Asp Gln Asn Ser Arg Leu Val Arg Ala Val Arg Glu Gly Met Cys Asp 
            340                 345                 350         


Ser Asp His Lys Arg Asp Leu Gly Gly Asp Ala Glu Val Asn Pro Phe 
        355                 360                 365             


Leu Trp His Arg Pro Ser Glu Glu Asp Ser Ser Ser Met Glu Gly Cys 
    370                 375                 380                 


His Ser Phe Ser Ala Ser Cys Leu Thr Gln Phe Cys Ile Leu Phe Lys 
385                 390                 395                 400 


Arg Thr Phe Leu Ser Ile Met Arg Asp Ser Val Leu Thr His Leu Arg 
                405                 410                 415     


Ile Thr Ser His Ile Gly Ile Gly Leu Leu Ile Gly Leu Leu Tyr Leu 
            420                 425                 430         


Gly Ile Gly Asn Glu Ala Lys Lys Val Leu Ser Asn Ser Gly Phe Leu 
        435                 440                 445             


Phe Phe Ser Met Leu Phe Leu Met Phe Ala Ala Leu Met Pro Thr Val 
    450                 455                 460                 


Leu Thr Phe Pro Leu Glu Met Gly Val Phe Leu Arg Glu His Leu Asn 
465                 470                 475                 480 


Tyr Trp Tyr Ser Leu Lys Ala Tyr Tyr Leu Ala Lys Thr Met Ala Asp 
                485                 490                 495     


Val Pro Phe Gln Ile Met Phe Pro Val Ala Tyr Cys Ser Ile Val Tyr 
            500                 505                 510         


Trp Met Thr Ser Gln Pro Ser Asp Ala Val Arg Phe Val Leu Phe Ala 
        515                 520                 525             


Ala Leu Gly Thr Met Thr Ser Leu Val Ala Gln Ser Leu Gly Leu Leu 
    530                 535                 540                 


Ile Gly Ala Ala Ser Thr Ser Leu Gln Val Ala Thr Phe Val Gly Pro 
545                 550                 555                 560 


Val Thr Ala Ile Pro Val Leu Leu Phe Ser Gly Phe Phe Val Ser Phe 
                565                 570                 575     


Asp Thr Ile Pro Thr Tyr Leu Gln Trp Met Ser Tyr Ile Ser Tyr Val 
            580                 585                 590         


Arg Tyr Gly Phe Glu Gly Val Ile Leu Ser Ile Tyr Gly Leu Asp Arg 
        595                 600                 605             


Glu Asp Leu His Cys Asp Ile Asp Glu Thr Cys His Phe Gln Lys Ser 
    610                 615                 620                 


Glu Ala Ile Leu Arg Glu Leu Asp Val Glu Asn Ala Lys Leu Tyr Leu 
625                 630                 635                 640 


Asp Phe Ile Val Leu Gly Ile Phe Phe Ile Ser Leu Arg Leu Ile Ala 
                645                 650                 655     


Tyr Phe Val Leu Arg Tyr Lys Ile Arg Ala Glu Arg 
            660                 665             


<210>  26
<211>  677
<212>  PRT
<213>  Homo Sapiens

<400>  26

Met Arg Ile Ser Leu Pro Arg Ala Pro Glu Arg Asp Gly Gly Val Ser 
1               5                   10                  15      


Ala Ser Ser Leu Leu Asp Thr Val Thr Asn Ala Ser Ser Tyr Ser Ala 
            20                  25                  30          


Glu Met Thr Glu Pro Lys Ser Val Cys Val Ser Val Asp Glu Val Val 
        35                  40                  45              


Ser Ser Asn Met Glu Ala Thr Glu Thr Asp Leu Leu Asn Gly His Leu 
    50                  55                  60                  


Lys Lys Val Asp Asn Asn Leu Thr Glu Ala Gln Arg Phe Ser Ser Leu 
65                  70                  75                  80  


Pro Arg Arg Ala Ala Val Asn Ile Glu Phe Arg Asp Leu Ser Tyr Ser 
                85                  90                  95      


Val Pro Glu Gly Pro Trp Trp Arg Lys Lys Gly Tyr Lys Thr Leu Leu 
            100                 105                 110         


Lys Gly Ile Ser Gly Lys Phe Asn Ser Gly Glu Leu Val Ala Ile Met 
        115                 120                 125             


Gly Pro Ser Gly Ala Gly Lys Ser Thr Leu Met Asn Ile Leu Ala Gly 
    130                 135                 140                 


Tyr Arg Glu Thr Gly Met Lys Gly Ala Val Leu Ile Asn Gly Leu Pro 
145                 150                 155                 160 


Arg Asp Leu Arg Cys Phe Arg Lys Val Ser Cys Tyr Ile Met Gln Asp 
                165                 170                 175     


Asp Met Leu Leu Pro His Leu Thr Val Gln Glu Ala Met Met Val Ser 
            180                 185                 190         


Ala His Leu Lys Leu Gln Glu Lys Asp Glu Gly Arg Arg Glu Met Val 
        195                 200                 205             


Lys Glu Ile Leu Thr Ala Leu Gly Leu Leu Ser Cys Ala Asn Thr Arg 
    210                 215                 220                 


Thr Gly Ser Leu Ser Gly Gly Gln Arg Lys Arg Leu Ala Ile Ala Leu 
225                 230                 235                 240 


Glu Leu Val Asn Asn Pro Pro Val Met Phe Phe Asp Glu Pro Thr Ser 
                245                 250                 255     


Gly Leu Asp Ser Ala Ser Cys Phe Gln Val Val Ser Leu Met Lys Gly 
            260                 265                 270         


Leu Ala Gln Gly Gly Arg Ser Ile Ile Cys Thr Ile His Gln Pro Ser 
        275                 280                 285             


Ala Lys Leu Phe Glu Leu Phe Asp Gln Leu Tyr Val Leu Ser Gln Gly 
    290                 295                 300                 


Gln Cys Val Tyr Arg Gly Lys Val Cys Asn Leu Val Pro Tyr Leu Arg 
305                 310                 315                 320 


Asp Leu Gly Leu Asn Cys Pro Thr Tyr His Asn Pro Ala Asp Phe Val 
                325                 330                 335     


Met Glu Val Ala Ser Gly Glu Tyr Gly Asp Gln Asn Ser Arg Leu Val 
            340                 345                 350         


Arg Ala Val Arg Glu Gly Met Cys Asp Ser Asp His Lys Arg Asp Leu 
        355                 360                 365             


Gly Gly Asp Ala Glu Val Asn Pro Phe Leu Trp His Arg Pro Ser Glu 
    370                 375                 380                 


Glu Asp Ser Ser Ser Met Glu Gly Cys His Ser Phe Ser Ala Ser Cys 
385                 390                 395                 400 


Leu Thr Gln Phe Cys Ile Leu Phe Lys Arg Thr Phe Leu Ser Ile Met 
                405                 410                 415     


Arg Asp Ser Val Leu Thr His Leu Arg Ile Thr Ser His Ile Gly Ile 
            420                 425                 430         


Gly Leu Leu Ile Gly Leu Leu Tyr Leu Gly Ile Gly Asn Glu Ala Lys 
        435                 440                 445             


Lys Val Leu Ser Asn Ser Gly Phe Leu Phe Phe Ser Met Leu Phe Leu 
    450                 455                 460                 


Met Phe Ala Ala Leu Met Pro Thr Val Leu Thr Phe Pro Leu Glu Met 
465                 470                 475                 480 


Gly Val Phe Leu Arg Glu His Leu Asn Tyr Trp Tyr Ser Leu Lys Ala 
                485                 490                 495     


Tyr Tyr Leu Ala Lys Thr Met Ala Asp Val Pro Phe Gln Ile Met Phe 
            500                 505                 510         


Pro Val Ala Tyr Cys Ser Ile Val Tyr Trp Met Thr Ser Gln Pro Ser 
        515                 520                 525             


Asp Ala Val Arg Phe Val Leu Phe Ala Ala Leu Gly Thr Met Thr Ser 
    530                 535                 540                 


Leu Val Ala Gln Ser Leu Gly Leu Leu Ile Gly Ala Ala Ser Thr Ser 
545                 550                 555                 560 


Leu Gln Val Ala Thr Phe Val Gly Pro Val Thr Ala Ile Pro Val Leu 
                565                 570                 575     


Leu Phe Ser Gly Phe Phe Val Ser Phe Asp Thr Ile Pro Thr Tyr Leu 
            580                 585                 590         


Gln Trp Met Ser Tyr Ile Ser Tyr Val Arg Tyr Gly Phe Glu Gly Val 
        595                 600                 605             


Ile Leu Ser Ile Tyr Gly Leu Asp Arg Glu Asp Leu His Cys Asp Ile 
    610                 615                 620                 


Asp Glu Thr Cys His Phe Gln Lys Ser Glu Ala Ile Leu Arg Glu Leu 
625                 630                 635                 640 


Asp Val Glu Asn Ala Lys Leu Tyr Leu Asp Phe Ile Val Leu Gly Ile 
                645                 650                 655     


Phe Phe Ile Ser Leu Arg Leu Ile Ala Tyr Phe Val Leu Arg Tyr Lys 
            660                 665                 670         


Ile Arg Ala Glu Arg 
        675         


<210>  27
<211>  177
<212>  PRT
<213>  Homo Sapiens

<400>  27

Met Ala Pro Gly Gln Thr Pro Ser Leu Cys Ser Trp Leu Leu Pro Leu 
1               5                   10                  15      


Pro Ser Thr Trp Ala Thr Thr Gly His Val Cys Phe Ser Asp Ile Leu 
            20                  25                  30          


Gln Thr Pro Asp Gly Gly Gln Leu Leu Leu Asp Trp Ala Lys Gln Pro 
        35                  40                  45              


Asp Ser Ser Gln Asp Pro Asp Pro Thr Thr Gln Pro Ile Val Leu Leu 
    50                  55                  60                  


Leu Pro Gly Ile Thr Gly Ser Ser Gln Glu Thr Tyr Val Leu His Leu 
65                  70                  75                  80  


Val Asn Gln Ala Leu Arg Asp Gly Tyr Gln Ala Val Val Phe Asn Asn 
                85                  90                  95      


Arg Gly Cys Arg Gly Glu Glu Leu Arg Thr His Arg Ala Phe Cys Ala 
            100                 105                 110         


Ser Asn Thr Glu Asp Leu Glu Thr Val Val Asn His Ile Lys His Arg 
        115                 120                 125             


Tyr Pro Gln Ala Pro Leu Leu Ala Val Gly Ile Ser Phe Gly Gly Ile 
    130                 135                 140                 


Leu Val Leu Asn His Leu Ala Gln Ala Arg Gln Ala Ala Gly Leu Val 
145                 150                 155                 160 


Ala Ala Leu Thr Leu Ser Ala Cys Trp Asp Ser Phe Glu Thr Thr Arg 
                165                 170                 175     


Ser 
    


<210>  28
<211>  102
<212>  PRT
<213>  Homo Sapiens

<400>  28

Met Ala Pro Gly Gln Thr Pro Ser Leu Cys Ser Trp Leu Leu Pro Leu 
1               5                   10                  15      


Pro Ser Thr Trp Ala Thr Thr Gly His Val Cys Phe Ser Asp Ile Leu 
            20                  25                  30          


Gln Thr Pro Asp Gly Gly Gln Leu Leu Leu Asp Trp Ala Lys Gln Pro 
        35                  40                  45              


Asp Ser Ser Gln Asp Pro Asp Pro Thr Thr Gln Pro Ile Val Leu Leu 
    50                  55                  60                  


Leu Pro Gly Ile Thr Gly Ser Ser Gln Glu Thr Tyr Val Leu His Leu 
65                  70                  75                  80  


Val Asn Gln Ala Leu Arg Asp Gly Tyr Gln Pro Thr Gly Leu Phe Val 
                85                  90                  95      


Pro Ala Ile Leu Lys Ile 
            100         


<210>  29
<211>  405
<212>  PRT
<213>  Homo Sapiens

<400>  29

Met Leu Ser Ser Phe Leu Ser Pro Gln Asn Gly Thr Trp Ala Asp Thr 
1               5                   10                  15      


Phe Ser Leu Leu Leu Ala Leu Ala Val Ala Leu Tyr Leu Gly Tyr Tyr 
            20                  25                  30          


Trp Ala Cys Val Leu Gln Arg Pro Arg Leu Val Ala Gly Pro Gln Phe 
        35                  40                  45              


Leu Ala Phe Leu Glu Pro His Cys Ser Ile Thr Thr Glu Thr Phe Tyr 
    50                  55                  60                  


Pro Thr Leu Trp Cys Phe Glu Gly Arg Leu Gln Ser Ile Phe Gln Val 
65                  70                  75                  80  


Leu Leu Gln Ser Gln Pro Leu Val Leu Tyr Gln Ser Asp Ile Leu Gln 
                85                  90                  95      


Thr Pro Asp Gly Gly Gln Leu Leu Leu Asp Trp Ala Lys Gln Pro Asp 
            100                 105                 110         


Ser Ser Gln Asp Pro Asp Pro Thr Thr Gln Pro Ile Val Leu Leu Leu 
        115                 120                 125             


Pro Gly Ile Thr Gly Ser Ser Gln Glu Thr Tyr Val Leu His Leu Val 
    130                 135                 140                 


Asn Gln Ala Leu Arg Asp Gly Tyr Gln Ala Val Val Phe Asn Asn Arg 
145                 150                 155                 160 


Gly Cys Arg Gly Glu Glu Leu Arg Thr His Arg Ala Phe Cys Ala Ser 
                165                 170                 175     


Asn Thr Glu Asp Leu Glu Thr Val Val Asn His Ile Lys His Arg Tyr 
            180                 185                 190         


Pro Gln Ala Pro Leu Leu Ala Val Gly Ile Ser Phe Gly Gly Ile Leu 
        195                 200                 205             


Val Leu Asn His Leu Ala Gln Ala Arg Gln Ala Ala Gly Leu Val Ala 
    210                 215                 220                 


Ala Leu Thr Leu Ser Ala Cys Trp Asp Ser Phe Glu Thr Thr Arg Ser 
225                 230                 235                 240 


Leu Glu Thr Pro Leu Asn Ser Leu Leu Phe Asn Gln Pro Leu Thr Ala 
                245                 250                 255     


Gly Leu Cys Gln Leu Val Glu Arg Asn Arg Lys Val Ile Glu Lys Val 
            260                 265                 270         


Val Asp Ile Asp Phe Val Leu Gln Ala Arg Thr Ile Arg Gln Phe Asp 
        275                 280                 285             


Glu Arg Tyr Thr Ser Val Ala Phe Gly Tyr Gln Asp Cys Val Thr Tyr 
    290                 295                 300                 


Tyr Lys Ala Ala Ser Pro Arg Thr Lys Ile Asp Ala Ile Arg Ile Pro 
305                 310                 315                 320 


Val Leu Tyr Leu Ser Ala Ala Asp Asp Pro Phe Ser Pro Val Cys Ala 
                325                 330                 335     


Leu Pro Ile Gln Ala Ala Gln His Ser Pro Tyr Val Ala Leu Leu Ile 
            340                 345                 350         


Thr Ala Arg Gly Gly His Ile Gly Phe Leu Glu Gly Leu Leu Pro Trp 
        355                 360                 365             


Gln His Trp Tyr Met Ser Arg Leu Leu His Gln Tyr Ala Lys Ala Ile 
    370                 375                 380                 


Phe Gln Asp Pro Glu Gly Leu Pro Asp Leu Arg Ala Leu Leu Pro Ser 
385                 390                 395                 400 


Glu Asp Arg Asn Ser 
                405 


<210>  30
<211>  305
<212>  PRT
<213>  Homo Sapiens

<400>  30

Met Leu Ser Ser Phe Leu Ser Pro Gln Asn Gly Thr Trp Ala Asp Thr 
1               5                   10                  15      


Phe Ser Leu Leu Leu Ala Leu Ala Val Ala Leu Tyr Leu Gly Tyr Tyr 
            20                  25                  30          


Trp Ala Cys Val Leu Gln Arg Pro Arg Leu Val Ala Gly Pro Gln Phe 
        35                  40                  45              


Leu Ala Phe Leu Glu Pro His Cys Ser Ile Thr Thr Glu Thr Phe Tyr 
    50                  55                  60                  


Pro Thr Leu Trp Cys Phe Glu Gly Arg Leu Gln Ser Ile Phe Gln Val 
65                  70                  75                  80  


Leu Leu Gln Ser Gln Pro Leu Val Leu Tyr Gln Ser Asp Ile Leu Gln 
                85                  90                  95      


Thr Pro Asp Gly Gly Gln Leu Leu Leu Asp Trp Ala Lys Gln Pro Asp 
            100                 105                 110         


Ser Ser Gln Asp Pro Asp Pro Thr Thr Gln Pro Ile Val Leu Leu Leu 
        115                 120                 125             


Pro Gly Ile Thr Gly Ser Ser Gln Glu Thr Tyr Val Leu His Leu Val 
    130                 135                 140                 


Asn Gln Ala Leu Arg Asp Gly Tyr Gln Ala Val Val Phe Asn Asn Arg 
145                 150                 155                 160 


Gly Cys Arg Gly Glu Glu Leu Arg Thr His Arg Ala Phe Cys Ala Ser 
                165                 170                 175     


Asn Thr Glu Asp Leu Glu Thr Val Val Asn His Ile Lys His Arg Tyr 
            180                 185                 190         


Pro Gln Ala Pro Leu Leu Ala Val Gly Ile Ser Phe Gly Gly Ile Leu 
        195                 200                 205             


Val Leu Asn His Leu Ala Gln Ala Arg Gln Ala Ala Gly Leu Val Ala 
    210                 215                 220                 


Ala Leu Thr Leu Ser Ala Cys Trp Asp Ser Phe Glu Thr Thr Arg Ser 
225                 230                 235                 240 


Leu Glu Thr Pro Leu Asn Ser Leu Leu Phe Asn Gln Pro Leu Thr Ala 
                245                 250                 255     


Gly Leu Cys Gln Leu Val Glu Arg Leu Ser Tyr Gly Lys Thr Cys Arg 
            260                 265                 270         


Pro Val Gln Ser Ala Ser Leu Met Ser Ala Thr His Leu Trp Pro Leu 
        275                 280                 285             


Asp Ile Lys Thr Val Leu Pro Thr Thr Lys Gln Gln Ala Leu Glu Pro 
    290                 295                 300                 


Arg 
305 


<210>  31
<211>  305
<212>  PRT
<213>  Homo Sapiens

<400>  31

Met Leu Ser Ser Phe Leu Ser Pro Gln Asn Gly Thr Trp Ala Asp Thr 
1               5                   10                  15      


Phe Ser Leu Leu Leu Ala Leu Ala Val Ala Leu Tyr Leu Gly Tyr Tyr 
            20                  25                  30          


Trp Ala Cys Val Leu Gln Arg Pro Arg Leu Val Ala Gly Pro Gln Phe 
        35                  40                  45              


Leu Ala Phe Leu Glu Pro His Cys Ser Ile Thr Thr Glu Thr Phe Tyr 
    50                  55                  60                  


Pro Thr Leu Trp Cys Phe Glu Gly Arg Leu Gln Ser Ile Phe Gln Val 
65                  70                  75                  80  


Leu Leu Gln Ser Gln Pro Leu Val Leu Tyr Gln Ser Asp Ile Leu Gln 
                85                  90                  95      


Thr Pro Asp Gly Gly Gln Leu Leu Leu Asp Trp Ala Lys Gln Pro Asp 
            100                 105                 110         


Ser Ser Gln Asp Pro Asp Pro Thr Thr Gln Pro Ile Val Leu Leu Leu 
        115                 120                 125             


Pro Gly Ile Thr Gly Ser Ser Gln Glu Thr Tyr Val Leu His Leu Val 
    130                 135                 140                 


Asn Gln Ala Leu Arg Asp Gly Tyr Gln Ala Val Val Phe Asn Asn Arg 
145                 150                 155                 160 


Gly Cys Arg Gly Glu Glu Leu Arg Thr His Arg Ala Phe Cys Ala Ser 
                165                 170                 175     


Asn Thr Glu Asp Leu Glu Thr Val Val Asn His Ile Lys His Arg Tyr 
            180                 185                 190         


Pro Gln Ala Pro Leu Leu Ala Val Gly Ile Ser Phe Gly Gly Ile Leu 
        195                 200                 205             


Val Leu Asn His Leu Ala Gln Ala Arg Gln Ala Ala Gly Leu Val Ala 
    210                 215                 220                 


Ala Leu Thr Leu Ser Ala Cys Trp Asp Ser Phe Glu Thr Thr Arg Ser 
225                 230                 235                 240 


Leu Glu Thr Pro Leu Asn Ser Leu Leu Phe Asn Gln Pro Leu Thr Ala 
                245                 250                 255     


Gly Leu Cys Gln Leu Val Glu Arg Leu Ser Tyr Gly Lys Thr Cys Arg 
            260                 265                 270         


Pro Val Gln Ser Ala Ser Leu Met Ser Ala Thr His Leu Trp Pro Leu 
        275                 280                 285             


Asp Ile Lys Thr Val Leu Pro Thr Thr Lys Gln Gln Ala Leu Glu Pro 
    290                 295                 300                 


Arg 
305 


<210>  32
<211>  205
<212>  PRT
<213>  Homo Sapiens

<400>  32

Met Ala Val Ala Arg Leu Ala Ala Val Ala Ala Trp Val Pro Cys Arg 
1               5                   10                  15      


Ser Trp Gly Trp Ala Ala Val Pro Phe Gly Pro His Arg Gly Leu Ser 
            20                  25                  30          


Val Leu Leu Ala Arg Ile Pro Gln Arg Ala Pro Arg Trp Leu Pro Ala 
        35                  40                  45              


Cys Arg Gln Lys Thr Ser Leu Ser Phe Leu Asn Arg Pro Asp Leu Pro 
    50                  55                  60                  


Asn Leu Ala Tyr Lys Lys Leu Lys Gly Lys Ser Pro Gly Ile Ile Phe 
65                  70                  75                  80  


Ile Pro Gly Tyr Leu Ser Tyr Met Asn Gly Thr Lys Ala Leu Ala Ile 
                85                  90                  95      


Glu Glu Phe Cys Lys Ser Leu Gly His Ala Cys Ile Arg Phe Asp Tyr 
            100                 105                 110         


Ser Gly Val Gly Ser Ser Asp Gly Asn Ser Glu Glu Ser Thr Leu Gly 
        115                 120                 125             


Lys Trp Arg Lys Asp Val Leu Ser Ile Ile Asp Asp Leu Ala Asp Gly 
    130                 135                 140                 


Pro Gln Ile Leu Val Gly Ser Ser Leu Gly Gly Trp Leu Met Leu His 
145                 150                 155                 160 


Ala Ala Ile Ala Arg Pro Glu Lys Val Val Ala Leu Ile Gly Val Ala 
                165                 170                 175     


Thr Ala Ala Asp Thr Leu Val Thr Lys Phe Asn Gln Leu Pro Val Glu 
            180                 185                 190         


Asp Ser Gly Arg Lys Asn Tyr Ile Ser Leu His Ser Ala 
        195                 200                 205 


<210>  33
<211>  306
<212>  PRT
<213>  Homo Sapiens

<400>  33

Met Ala Val Ala Arg Leu Ala Ala Val Ala Ala Trp Val Pro Cys Arg 
1               5                   10                  15      


Ser Trp Gly Trp Ala Ala Val Pro Phe Gly Pro His Arg Gly Leu Ser 
            20                  25                  30          


Val Leu Leu Ala Arg Ile Pro Gln Arg Ala Pro Arg Trp Leu Pro Ala 
        35                  40                  45              


Cys Arg Gln Lys Thr Ser Leu Ser Phe Leu Asn Arg Pro Asp Leu Pro 
    50                  55                  60                  


Asn Leu Ala Tyr Lys Lys Leu Lys Gly Lys Ser Pro Gly Ile Ile Phe 
65                  70                  75                  80  


Ile Pro Gly Tyr Leu Ser Tyr Met Asn Gly Thr Lys Ala Leu Ala Ile 
                85                  90                  95      


Glu Glu Phe Cys Lys Ser Leu Gly His Ala Cys Ile Arg Phe Asp Tyr 
            100                 105                 110         


Ser Gly Val Gly Ser Ser Asp Gly Asn Ser Glu Glu Ser Thr Leu Gly 
        115                 120                 125             


Lys Trp Arg Lys Asp Val Leu Ser Ile Ile Asp Asp Leu Ala Asp Gly 
    130                 135                 140                 


Pro Gln Ile Leu Val Gly Ser Ser Leu Gly Gly Trp Leu Met Leu His 
145                 150                 155                 160 


Ala Ala Ile Ala Arg Pro Glu Lys Val Val Ala Leu Ile Gly Val Ala 
                165                 170                 175     


Thr Ala Ala Asp Thr Leu Val Thr Lys Phe Asn Gln Leu Pro Val Glu 
            180                 185                 190         


Leu Lys Lys Glu Val Glu Met Lys Gly Val Trp Ser Met Pro Ser Lys 
        195                 200                 205             


Tyr Ser Glu Glu Gly Val Tyr Asn Val Gln Tyr Ser Phe Ile Lys Glu 
    210                 215                 220                 


Ala Glu His His Cys Leu Leu His Ser Pro Ile Pro Val Asn Cys Pro 
225                 230                 235                 240 


Ile Arg Leu Leu His Gly Met Lys Asp Asp Ile Val Pro Trp His Thr 
                245                 250                 255     


Ser Met Gln Val Ala Asp Arg Val Leu Ser Thr Asp Val Asp Val Ile 
            260                 265                 270         


Leu Arg Lys His Ser Asp His Arg Met Arg Glu Lys Ala Asp Ile Gln 
        275                 280                 285             


Leu Leu Val Tyr Thr Ile Asp Asp Leu Ile Asp Lys Leu Ser Thr Ile 
    290                 295                 300                 


Val Asn 
305     


<210>  34
<211>  52
<212>  PRT
<213>  Homo Sapiens

<400>  34

Met Ala Val Ala Arg Leu Ala Ala Val Ala Ala Trp Val Pro Cys Arg 
1               5                   10                  15      


Ser Trp Gly Trp Ala Ala Val Pro Phe Gly Pro His Arg Gly Leu Ser 
            20                  25                  30          


Val Leu Leu Ala Arg Ile Pro Gln Arg Ala Pro Arg Trp Leu Pro Asp 
        35                  40                  45              


Ser Cys Trp Ile 
    50          


<210>  35
<211>  75
<212>  PRT
<213>  Homo Sapiens

<400>  35

Met Ala Val Ala Arg Leu Ala Ala Val Ala Ala Trp Val Pro Cys Arg 
1               5                   10                  15      


Ser Trp Gly Trp Ala Ala Val Pro Phe Gly Pro His Arg Gly Leu Ser 
            20                  25                  30          


Val Leu Leu Ala Arg Ile Pro Gln Arg Ala Pro Arg Trp Leu Pro Gly 
        35                  40                  45              


Leu Ile Thr Gln Glu Leu Glu Val Gln Met Val Thr Gln Arg Lys Ala 
    50                  55                  60                  


His Trp Gly Asn Gly Glu Lys Met Phe Phe Leu 
65                  70                  75  


<210>  36
<211>  229
<212>  PRT
<213>  Homo Sapiens

<400>  36

Met Leu Leu Leu Tyr Val Gly Leu Pro Gly Pro Pro Glu Gln Thr Ser 
1               5                   10                  15      


Cys Leu Trp Gly Asp Pro Asn Val Thr Val Leu Ala Gly Leu Thr Pro 
            20                  25                  30          


Gly Asn Ser Pro Ile Phe Tyr Arg Glu Val Leu Pro Leu Asn Gln Ala 
        35                  40                  45              


His Arg Val Glu Val Val Leu Leu His Gly Lys Ala Phe Asn Ser His 
    50                  55                  60                  


Thr Trp Glu Gln Leu Gly Thr Leu Gln Leu Leu Ser Gln Arg Gly Tyr 
65                  70                  75                  80  


Arg Ala Val Ala Leu Asp Leu Pro Val Pro Gly Ser Ser Asn Ser Pro 
                85                  90                  95      


Ala Ser Ala Ser Pro Val Ala Glu Ile Thr Glu Asn Ser Phe Trp Ala 
            100                 105                 110         


Val Leu Val Arg Asp Leu Glu Val Gln Asn Ala Val Leu Val Ser Pro 
        115                 120                 125             


Ser Leu Ser Gly His Tyr Ala Leu Pro Phe Leu Met Arg Gly His His 
    130                 135                 140                 


Gln Leu His Gly Phe Val Pro Ile Ala Pro Thr Ser Thr Gln Asn Tyr 
145                 150                 155                 160 


Thr Gln Glu Gln Phe Trp Ala Val Lys Thr Pro Thr Leu Ile Leu Tyr 
                165                 170                 175     


Gly Glu Leu Asp His Ile Leu Ala Arg Glu Ser Leu Arg Gln Leu Arg 
            180                 185                 190         


His Leu Pro Asn His Ser Val Val Lys Leu Arg Asn Ala Gly His Ala 
        195                 200                 205             


Cys Tyr Leu His Lys Pro Gln Asp Phe His Leu Val Leu Leu Ala Phe 
    210                 215                 220                 


Leu Asp His Leu Pro 
225                 


<210>  37
<211>  225
<212>  PRT
<213>  Homo Sapiens

<400>  37

Met Gln Gln Gln Tyr Arg Glu Ala Ser Leu Pro Thr Ala Gly Gln Gly 
1               5                   10                  15      


Leu Ser Glu Glu Glu Gly Leu Ala Leu His Leu Asp Gly Ala Leu Ala 
            20                  25                  30          


Leu Leu His Ala Cys Cys His Ala Cys Cys Cys Cys Ala Gly Glu Gly 
        35                  40                  45              


Pro Val Val Gln Asn His Asp Asp Glu Gly Pro Gln Asn Thr Leu Pro 
    50                  55                  60                  


Arg Val Ala Val Pro Glu Glu Gln Gln Gly Ser Leu Gln Glu Val Ser 
65                  70                  75                  80  


Arg Thr Leu Arg Thr Cys Leu Gly Thr Val Val Gln Thr Ser Met Ser 
                85                  90                  95      


Arg Ser Gln Val Ala Leu Leu Gly Leu Ser Leu Leu Leu Met Leu Leu 
            100                 105                 110         


Leu Tyr Val Gly Leu Pro Gly Pro Pro Glu Gln Thr Ser Cys Leu Trp 
        115                 120                 125             


Gly Asp Pro Asn Val Thr Val Leu Ala Gly Leu Thr Pro Gly Asn Ser 
    130                 135                 140                 


Pro Ile Phe Tyr Arg Glu Val Leu Pro Leu Asn Gln Ala His Arg Val 
145                 150                 155                 160 


Glu Val Val Leu Leu His Gly Lys Ala Phe Asn Ser His Thr Trp Glu 
                165                 170                 175     


Gln Leu Gly Thr Leu Gln Leu Leu Ser Gln Arg Gly Tyr Arg Ala Val 
            180                 185                 190         


Ala Leu Asp Leu Pro Gly Phe Gly Asn Ser Ala Pro Ser Lys Glu Ala 
        195                 200                 205             


Ser Thr Glu Ala Gly Arg Ala Ala Leu Leu Glu Arg Ala Leu Arg Asp 
    210                 215                 220                 


Leu 
225 


<210>  38
<211>  153
<212>  PRT
<213>  Homo Sapiens

<400>  38

Met Val Ala Thr Pro Lys Glu Gly Thr Gln Gly Ser Glu Lys Gly Arg 
1               5                   10                  15      


Leu Gly Thr Val Val Gln Thr Ser Met Ser Arg Ser Gln Val Ala Leu 
            20                  25                  30          


Leu Gly Leu Ser Leu Leu Leu Met Leu Leu Leu Tyr Val Gly Leu Pro 
        35                  40                  45              


Gly Pro Pro Glu Gln Thr Ser Cys Leu Trp Gly Asp Pro Asn Val Thr 
    50                  55                  60                  


Val Leu Ala Gly Leu Thr Pro Gly Asn Ser Pro Ile Phe Tyr Arg Glu 
65                  70                  75                  80  


Val Leu Pro Leu Asn Gln Ala His Arg Val Glu Val Val Leu Leu His 
                85                  90                  95      


Gly Lys Ala Phe Asn Ser His Thr Trp Glu Gln Leu Gly Thr Leu Gln 
            100                 105                 110         


Leu Leu Ser Gln Arg Gly Tyr Arg Ala Val Ala Leu Asp Leu Pro Gly 
        115                 120                 125             


Phe Gly Asn Ser Ala Pro Ser Lys Glu Ala Ser Thr Glu Ala Gly Arg 
    130                 135                 140                 


Ala Ala Leu Leu Glu Arg Ala Leu Arg 
145                 150             


<210>  39
<211>  124
<212>  PRT
<213>  Homo Sapiens

<400>  39

Met Val Gly Ala Leu Cys Gly Cys Trp Phe Arg Leu Gly Gly Ala Arg 
1               5                   10                  15      


Pro Leu Ile Pro Leu Gly Pro Thr Val Val Gln Thr Ser Met Ser Arg 
            20                  25                  30          


Ser Gln Val Ala Leu Leu Gly Leu Ser Leu Leu Leu Met Leu Leu Leu 
        35                  40                  45              


Tyr Val Gly Leu Pro Gly Pro Pro Glu Gln Thr Ser Cys Leu Trp Gly 
    50                  55                  60                  


Asp Pro Asn Val Thr Val Leu Ala Gly Leu Thr Pro Gly Asn Ser Pro 
65                  70                  75                  80  


Ile Phe Tyr Arg Glu Val Leu Pro Leu Asn Gln Ala His Arg Leu Gln 
                85                  90                  95      


Pro Leu Ser Cys Met Glu Ser Trp Thr Thr Ser Trp Leu Glu Ser His 
            100                 105                 110         


Cys Gly Ser Ser Ala Thr Cys Pro Thr Thr Leu Trp 
        115                 120                 


<210>  40
<211>  271
<212>  PRT
<213>  Homo Sapiens

<400>  40

Met Val Gly Ala Leu Cys Gly Cys Trp Phe Arg Leu Gly Gly Ala Arg 
1               5                   10                  15      


Pro Leu Ile Pro Leu Gly Pro Thr Val Val Gln Thr Ser Met Ser Arg 
            20                  25                  30          


Ser Gln Val Ala Leu Leu Gly Leu Ser Leu Leu Leu Met Leu Leu Leu 
        35                  40                  45              


Tyr Val Gly Leu Pro Gly Pro Pro Glu Gln Thr Ser Cys Leu Trp Gly 
    50                  55                  60                  


Asp Pro Asn Val Thr Val Leu Ala Gly Leu Thr Pro Gly Asn Ser Pro 
65                  70                  75                  80  


Ile Phe Tyr Arg Glu Val Leu Pro Leu Asn Gln Ala His Arg Val Glu 
                85                  90                  95      


Val Val Leu Leu His Gly Lys Ala Phe Asn Ser His Thr Trp Glu Gln 
            100                 105                 110         


Leu Gly Thr Leu Gln Leu Leu Ser Gln Arg Gly Tyr Arg Ala Val Ala 
        115                 120                 125             


Leu Asp Leu Pro Gly Phe Gly Asn Ser Ala Pro Ser Lys Glu Ala Ser 
    130                 135                 140                 


Thr Glu Ala Gly Arg Ala Ala Leu Leu Glu Arg Ala Leu Arg Asp Leu 
145                 150                 155                 160 


Glu Val Gln Asn Ala Val Leu Val Ser Pro Ser Leu Ser Gly His Tyr 
                165                 170                 175     


Ala Leu Pro Phe Leu Met Arg Gly His His Gln Leu His Gly Phe Val 
            180                 185                 190         


Pro Ile Ala Pro Thr Ser Thr Gln Asn Tyr Thr Gln Glu Gln Phe Trp 
        195                 200                 205             


Ala Val Lys Thr Pro Thr Leu Ile Leu Tyr Gly Glu Leu Asp His Ile 
    210                 215                 220                 


Leu Ala Arg Glu Ser Leu Arg Gln Leu Arg His Leu Pro Asn His Ser 
225                 230                 235                 240 


Val Val Lys Leu Arg Asn Ala Gly His Ala Cys Tyr Leu His Lys Pro 
                245                 250                 255     


Gln Asp Phe His Leu Val Leu Leu Ala Phe Leu Asp His Leu Pro 
            260                 265                 270     


<210>  41
<211>  468
<212>  PRT
<213>  Homo Sapiens

<400>  41

Met Pro Pro Trp Gly Ala Ala Leu Ala Leu Ile Leu Ala Val Leu Ala 
1               5                   10                  15      


Leu Leu Gly Leu Leu Gly Pro Arg Leu Arg Gly Pro Trp Gly Arg Ala 
            20                  25                  30          


Val Gly Glu Arg Thr Leu Pro Gly Ala Gln Asp Arg Asp Asp Gly Glu 
        35                  40                  45              


Glu Ala Asp Gly Gly Gly Pro Ala Asp Gln Phe Ser Asp Gly Arg Glu 
    50                  55                  60                  


Pro Leu Pro Gly Gly Cys Ser Leu Val Cys Lys Pro Ser Ala Leu Ala 
65                  70                  75                  80  


Gln Cys Leu Leu Arg Ala Leu Arg Arg Ser Glu Ala Leu Glu Ala Gly 
                85                  90                  95      


Pro Arg Ser Trp Phe Ser Gly Pro His Leu Gln Thr Leu Cys His Phe 
            100                 105                 110         


Val Leu Pro Val Ala Pro Gly Pro Glu Leu Ala Arg Glu Tyr Leu Gln 
        115                 120                 125             


Leu Ala Asp Asp Gly Leu Val Ala Leu Asp Trp Val Val Gly Pro Cys 
    130                 135                 140                 


Val Arg Gly Arg Arg Ile Thr Ser Ala Gly Gly Leu Pro Ala Val Leu 
145                 150                 155                 160 


Leu Val Ile Pro Asn Ala Trp Gly Arg Leu Thr Arg Asn Val Leu Gly 
                165                 170                 175     


Leu Cys Leu Leu Ala Leu Glu Arg Gly Tyr Tyr Pro Val Ile Phe His 
            180                 185                 190         


Arg Arg Gly His His Gly Cys Pro Leu Val Ser Pro Arg Leu Gln Pro 
        195                 200                 205             


Phe Gly Asp Pro Ser Asp Leu Lys Glu Ala Val Thr Tyr Ile Arg Phe 
    210                 215                 220                 


Arg His Pro Ala Ala Pro Leu Phe Ala Val Ser Glu Gly Ser Gly Ser 
225                 230                 235                 240 


Ala Leu Leu Leu Ser Tyr Leu Gly Glu Cys Gly Ser Ser Ser Tyr Val 
                245                 250                 255     


Thr Gly Ala Ala Cys Ile Ser Pro Val Leu Arg Cys Arg Glu Trp Phe 
            260                 265                 270         


Glu Ala Gly Leu Pro Trp Pro Tyr Glu Arg Gly Phe Leu Leu His Gln 
        275                 280                 285             


Lys Ile Ala Leu Ser Arg Tyr Ala Thr Ala Leu Glu Asp Thr Val Asp 
    290                 295                 300                 


Thr Ser Arg Leu Phe Arg Ser Arg Ser Leu Arg Glu Phe Glu Glu Ala 
305                 310                 315                 320 


Leu Phe Cys His Thr Lys Ser Phe Pro Ile Ser Trp Asp Thr Tyr Trp 
                325                 330                 335     


Asp Arg Asn Asp Pro Leu Arg Asp Val Asp Glu Ala Ala Val Pro Val 
            340                 345                 350         


Leu Cys Ile Cys Ser Ala Asp Asp Pro Val Cys Gly Pro Pro Asp His 
        355                 360                 365             


Thr Leu Thr Thr Glu Leu Phe His Ser Asn Pro Tyr Phe Phe Leu Leu 
    370                 375                 380                 


Leu Ser Arg His Gly Gly His Cys Gly Phe Leu Arg Gln Glu Pro Leu 
385                 390                 395                 400 


Pro Ala Trp Ser His Glu Val Ile Leu Glu Ser Phe Arg Ala Leu Thr 
                405                 410                 415     


Glu Phe Phe Arg Thr Glu Glu Arg Ile Lys Gly Leu Ser Arg His Arg 
            420                 425                 430         


Ala Ser Phe Leu Gly Gly Arg Arg Arg Gly Gly Ala Leu Gln Arg Arg 
        435                 440                 445             


Glu Val Ser Ser Ser Ser Asn Leu Glu Glu Ile Phe Asn Trp Lys Arg 
    450                 455                 460                 


Ser Tyr Thr Arg 
465             


<210>  42
<211>  191
<212>  PRT
<213>  Homo Sapiens

<400>  42

Cys Ile Val Val Leu Trp Tyr Gly Trp Leu His Phe Tyr Ala Glu Pro 
1               5                   10                  15      


Lys Tyr Leu Ile Val Val Arg Pro Ala Pro Pro Pro Ser Gln Lys Lys 
            20                  25                  30          


Ser Cys Ser Gly Lys Thr Arg Ser Arg Lys Pro Leu Gln Leu Val Val 
        35                  40                  45              


Gly Thr Leu Thr Pro Ser Ser Val Phe Leu Ser Trp Gly Phe Leu Ile 
    50                  55                  60                  


Asn Pro His His Asp Trp Thr Leu Pro Ser His Cys Pro Asn Asp Arg 
65                  70                  75                  80  


Phe Tyr Thr Ile Arg Tyr Arg Glu Lys Asp Lys Glu Lys Lys Trp Ile 
                85                  90                  95      


Phe Gln Ile Cys Pro Ala Thr Glu Thr Ile Val Glu Asn Leu Lys Pro 
            100                 105                 110         


Asn Thr Val Tyr Glu Phe Gly Val Lys Asp Asn Val Glu Gly Gly Ile 
        115                 120                 125             


Trp Ser Lys Ile Phe Asn His Lys Thr Val Val Gly Ser Lys Lys Val 
    130                 135                 140                 


Asn Gly Lys Ile Gln Ser Thr Tyr Asp Gln Asp His Thr Val Pro Ala 
145                 150                 155                 160 


Tyr Val Pro Arg Lys Leu Ile Pro Ile Thr Ile Ile Lys Gln Val Ile 
                165                 170                 175     


Gln Asn Val Thr His Lys Asp Ser Ala Lys Ser Pro Glu Lys Ala 
            180                 185                 190     


<210>  43
<211>  60
<212>  PRT
<213>  Homo Sapiens

<400>  43

Met Arg Gly Gly Lys Cys Asn Met Leu Ser Ser Leu Gly Cys Leu Leu 
1               5                   10                  15      


Leu Cys Gly Ser Ile Thr Leu Ala Leu Gly Asn Ala Gln Lys Leu Pro 
            20                  25                  30          


Lys Ala Asn Lys Arg Thr Glu Leu Val Ile Gln His Gly Trp Met Ser 
        35                  40                  45              


Leu Ile Lys Met Met Leu Asn Glu Arg Ser Gln Val 
    50                  55                  60  


<210>  44
<211>  161
<212>  PRT
<213>  Homo Sapiens

<400>  44

Met Arg Gly Gly Lys Cys Asn Met Leu Ser Ser Leu Gly Cys Leu Leu 
1               5                   10                  15      


Leu Cys Gly Ser Ile Thr Leu Ala Leu Gly Asn Ala Gln Lys Leu Pro 
            20                  25                  30          


Lys Asp Ala Glu Pro Lys Tyr Leu Ile Val Val Arg Pro Ala Pro Pro 
        35                  40                  45              


Pro Ser Gln Lys Lys Ser Cys Ser Gly Lys Thr Arg Ser Arg Lys Pro 
    50                  55                  60                  


Leu Gln Leu Val Val Gly Thr Leu Thr Pro Ser Ser Val Phe Leu Ser 
65                  70                  75                  80  


Trp Gly Phe Leu Ile Asn Pro His His Asp Trp Thr Leu Pro Ser His 
                85                  90                  95      


Cys Pro Asn Asp Arg Phe Tyr Thr Ile Arg Tyr Arg Glu Lys Asp Lys 
            100                 105                 110         


Glu Lys Lys Trp Ile Phe Gln Ile Cys Pro Ala Thr Glu Thr Ile Val 
        115                 120                 125             


Glu Asn Leu Lys Pro Asn Thr Val Tyr Glu Phe Gly Val Lys Asp Asn 
    130                 135                 140                 


Val Glu Gly Gly Ile Trp Ser Lys Ile Phe Asn His Lys Thr Val Val 
145                 150                 155                 160 


Gly 
    


<210>  45
<211>  1075
<212>  PRT
<213>  Homo Sapiens

<400>  45

Met Arg Gly Gly Lys Cys Asn Met Leu Ser Ser Leu Gly Cys Leu Leu 
1               5                   10                  15      


Leu Cys Gly Ser Ile Thr Leu Ala Leu Gly Asn Ala Gln Lys Leu Pro 
            20                  25                  30          


Lys Gly Lys Arg Pro Asn Leu Lys Val His Ile Asn Thr Thr Ser Asp 
        35                  40                  45              


Ser Ile Leu Leu Lys Phe Leu Arg Pro Ser Pro Asn Val Lys Leu Glu 
    50                  55                  60                  


Gly Leu Leu Leu Gly Tyr Gly Ser Asn Val Ser Pro Asn Gln Tyr Phe 
65                  70                  75                  80  


Pro Leu Pro Ala Glu Gly Lys Phe Thr Glu Ala Ile Val Asp Ala Glu 
                85                  90                  95      


Pro Lys Tyr Leu Ile Val Val Arg Pro Ala Pro Pro Pro Ser Gln Lys 
            100                 105                 110         


Lys Ser Cys Ser Gly Lys Thr Arg Ser Arg Lys Pro Leu Gln Leu Val 
        115                 120                 125             


Val Gly Thr Leu Thr Pro Ser Ser Val Phe Leu Ser Trp Gly Phe Leu 
    130                 135                 140                 


Ile Asn Pro His His Asp Trp Thr Leu Pro Ser His Cys Pro Asn Asp 
145                 150                 155                 160 


Arg Phe Tyr Thr Ile Arg Tyr Arg Glu Lys Asp Lys Glu Lys Lys Trp 
                165                 170                 175     


Ile Phe Gln Ile Cys Pro Ala Thr Glu Thr Ile Val Glu Asn Leu Lys 
            180                 185                 190         


Pro Asn Thr Val Tyr Glu Phe Gly Val Lys Asp Asn Val Glu Gly Gly 
        195                 200                 205             


Ile Trp Ser Lys Ile Phe Asn His Lys Thr Val Val Gly Ser Lys Lys 
    210                 215                 220                 


Val Asn Gly Lys Ile Gln Ser Thr Tyr Asp Gln Asp His Thr Val Pro 
225                 230                 235                 240 


Ala Tyr Val Pro Arg Lys Leu Ile Pro Ile Thr Ile Ile Lys Gln Val 
                245                 250                 255     


Ile Gln Asn Val Thr His Lys Asp Ser Ala Lys Ser Pro Glu Lys Ala 
            260                 265                 270         


Pro Leu Gly Gly Val Ile Leu Val His Leu Ile Ile Pro Gly Leu Asn 
        275                 280                 285             


Glu Thr Thr Val Lys Leu Pro Ala Ser Leu Met Phe Glu Ile Ser Asp 
    290                 295                 300                 


Ala Leu Lys Thr Gln Leu Ala Lys Asn Glu Thr Leu Ala Leu Pro Ala 
305                 310                 315                 320 


Glu Ser Lys Thr Pro Glu Val Glu Lys Ile Ser Ala Arg Pro Thr Thr 
                325                 330                 335     


Val Thr Pro Glu Thr Val Pro Arg Ser Thr Lys Pro Thr Thr Ser Ser 
            340                 345                 350         


Ala Leu Asp Val Ser Glu Thr Thr Leu Ala Ser Ser Glu Lys Pro Trp 
        355                 360                 365             


Ile Val Pro Thr Ala Lys Ile Ser Glu Asp Ser Lys Val Leu Gln Pro 
    370                 375                 380                 


Gln Thr Ala Thr Tyr Asp Val Phe Ser Ser Pro Thr Thr Ser Asp Glu 
385                 390                 395                 400 


Pro Glu Ile Ser Asp Ser Tyr Thr Ala Thr Ser Asp Arg Ile Leu Asp 
                405                 410                 415     


Ser Ile Pro Pro Lys Thr Ser Arg Thr Leu Glu Gln Pro Arg Ala Thr 
            420                 425                 430         


Leu Ala Pro Ser Glu Thr Pro Phe Val Pro Gln Lys Leu Glu Ile Phe 
        435                 440                 445             


Thr Ser Pro Glu Met Gln Pro Thr Thr Pro Ala Pro Gln Gln Thr Thr 
    450                 455                 460                 


Ser Ile Pro Ser Thr Pro Lys Arg Arg Pro Arg Pro Lys Pro Pro Arg 
465                 470                 475                 480 


Thr Lys Pro Glu Arg Thr Thr Ser Ala Gly Thr Ile Thr Pro Lys Ile 
                485                 490                 495     


Ser Lys Ser Pro Glu Pro Thr Trp Thr Thr Pro Ala Pro Gly Lys Thr 
            500                 505                 510         


Gln Phe Ile Ser Leu Lys Pro Lys Ile Pro Leu Ser Pro Glu Val Thr 
        515                 520                 525             


His Thr Lys Pro Ala Pro Lys Gln Thr Pro Arg Ala Pro Pro Lys Pro 
    530                 535                 540                 


Lys Thr Ser Pro Arg Pro Arg Ile Pro Gln Thr Gln Pro Val Pro Lys 
545                 550                 555                 560 


Val Pro Gln Arg Val Thr Ala Lys Pro Lys Thr Ser Pro Ser Pro Glu 
                565                 570                 575     


Val Ser Tyr Thr Thr Pro Ala Pro Lys Asp Val Leu Leu Pro His Lys 
            580                 585                 590         


Pro Tyr Pro Glu Val Ser Gln Ser Glu Pro Ala Pro Leu Glu Thr Arg 
        595                 600                 605             


Gly Ile Pro Phe Ile Pro Met Ile Ser Pro Ser Pro Ser Gln Glu Glu 
    610                 615                 620                 


Leu Gln Thr Thr Leu Glu Glu Thr Asp Gln Ser Thr Gln Glu Pro Phe 
625                 630                 635                 640 


Thr Thr Lys Ile Pro Arg Thr Thr Glu Leu Ala Lys Thr Thr Gln Ala 
                645                 650                 655     


Pro His Arg Phe Tyr Thr Thr Val Arg Pro Arg Thr Ser Asp Lys Pro 
            660                 665                 670         


His Ile Arg Pro Gly Val Lys Gln Ala Pro Arg Pro Ser Gly Ala Asp 
        675                 680                 685             


Arg Asn Val Ser Val Asp Ser Thr His Pro Thr Lys Lys Pro Gly Thr 
    690                 695                 700                 


Arg Arg Pro Pro Leu Pro Pro Arg Pro Thr His Pro Arg Arg Lys Pro 
705                 710                 715                 720 


Leu Pro Pro Asn Asn Val Thr Gly Lys Pro Gly Ser Ala Gly Ile Ile 
                725                 730                 735     


Ser Ser Gly Pro Ile Thr Thr Pro Pro Leu Arg Ser Thr Pro Arg Pro 
            740                 745                 750         


Thr Gly Thr Pro Leu Glu Arg Ile Glu Thr Asp Ile Lys Gln Pro Thr 
        755                 760                 765             


Val Pro Ala Ser Gly Glu Glu Leu Glu Asn Ile Thr Asp Phe Ser Ser 
    770                 775                 780                 


Ser Pro Thr Arg Glu Thr Asp Pro Leu Gly Lys Pro Arg Phe Lys Gly 
785                 790                 795                 800 


Pro His Val Arg Tyr Ile Gln Lys Pro Asp Asn Ser Pro Cys Ser Ile 
                805                 810                 815     


Thr Asp Ser Val Lys Arg Phe Pro Lys Glu Glu Ala Thr Glu Gly Asn 
            820                 825                 830         


Ala Thr Ser Pro Pro Gln Asn Pro Pro Thr Asn Leu Thr Val Val Thr 
        835                 840                 845             


Val Glu Gly Cys Pro Ser Phe Val Ile Leu Asp Trp Glu Lys Pro Leu 
    850                 855                 860                 


Asn Asp Thr Val Thr Glu Tyr Glu Val Ile Ser Arg Glu Asn Gly Ser 
865                 870                 875                 880 


Phe Ser Gly Lys Asn Lys Ser Ile Gln Met Thr Asn Gln Thr Phe Ser 
                885                 890                 895     


Thr Val Glu Asn Leu Lys Pro Asn Thr Ser Tyr Glu Phe Gln Val Lys 
            900                 905                 910         


Pro Lys Asn Pro Leu Gly Glu Gly Pro Val Ser Asn Thr Val Ala Phe 
        915                 920                 925             


Ser Thr Glu Ser Ala Asp Pro Arg Val Ser Glu Pro Val Ser Ala Gly 
    930                 935                 940                 


Arg Asp Ala Ile Trp Thr Glu Arg Pro Phe Asn Ser Asp Ser Tyr Ser 
945                 950                 955                 960 


Glu Cys Lys Gly Lys Gln Tyr Val Lys Arg Thr Trp Tyr Lys Lys Phe 
                965                 970                 975     


Val Gly Val Gln Leu Cys Asn Ser Leu Arg Tyr Lys Ile Tyr Leu Ser 
            980                 985                 990         


Asp Ser Leu Thr Gly Lys Phe Tyr  Asn Ile Gly Asp Gln  Arg Gly His 
        995                 1000                 1005             


Gly Glu  Asp His Cys Gln Phe  Val Asp Ser Phe Leu  Asp Gly Arg 
    1010                 1015                 1020             


Thr Gly  Gln Gln Leu Thr Ser  Asp Gln Leu Pro Ile  Lys Glu Gly 
    1025                 1030                 1035             


Tyr Phe  Arg Ala Val Arg Gln  Glu Pro Val Gln Phe  Gly Glu Ile 
    1040                 1045                 1050             


Gly Gly  His Thr Gln Ile Asn  Tyr Val Gln Trp Tyr  Glu Cys Gly 
    1055                 1060                 1065             


Thr Thr  Ile Pro Gly Lys Trp  
    1070                 1075 


<210>  46
<211>  1777
<212>  PRT
<213>  Homo Sapiens

<400>  46

Met Arg Gly Gly Lys Cys Asn Met Leu Ser Ser Leu Gly Cys Leu Leu 
1               5                   10                  15      


Leu Cys Gly Ser Ile Thr Leu Ala Leu Gly Asn Ala Gln Lys Leu Pro 
            20                  25                  30          


Lys Gly Lys Arg Pro Asn Leu Lys Val His Ile Asn Thr Thr Ser Asp 
        35                  40                  45              


Ser Ile Leu Leu Lys Phe Leu Arg Pro Ser Pro Asn Val Lys Leu Glu 
    50                  55                  60                  


Gly Leu Leu Leu Gly Tyr Gly Ser Asn Val Ser Pro Asn Gln Tyr Phe 
65                  70                  75                  80  


Pro Leu Pro Ala Glu Gly Lys Phe Thr Glu Ala Ile Val Asp Ala Glu 
                85                  90                  95      


Pro Lys Tyr Leu Ile Val Val Arg Pro Ala Pro Pro Pro Ser Gln Lys 
            100                 105                 110         


Lys Ser Cys Ser Gly Lys Thr Arg Ser Arg Lys Pro Leu Gln Leu Val 
        115                 120                 125             


Val Gly Thr Leu Thr Pro Ser Ser Val Phe Leu Ser Trp Gly Phe Leu 
    130                 135                 140                 


Ile Asn Pro His His Asp Trp Thr Leu Pro Ser His Cys Pro Asn Asp 
145                 150                 155                 160 


Arg Phe Tyr Thr Ile Arg Tyr Arg Glu Lys Asp Lys Glu Lys Lys Trp 
                165                 170                 175     


Ile Phe Gln Ile Cys Pro Ala Thr Glu Thr Ile Val Glu Asn Leu Lys 
            180                 185                 190         


Pro Asn Thr Val Tyr Glu Phe Gly Val Lys Asp Asn Val Glu Gly Gly 
        195                 200                 205             


Ile Trp Ser Lys Ile Phe Asn His Lys Thr Val Val Gly Ser Lys Lys 
    210                 215                 220                 


Val Asn Gly Lys Ile Gln Ser Thr Tyr Asp Gln Asp His Thr Val Pro 
225                 230                 235                 240 


Ala Tyr Val Pro Arg Lys Leu Ile Pro Ile Thr Ile Ile Lys Gln Val 
                245                 250                 255     


Ile Gln Asn Val Thr His Lys Asp Ser Ala Lys Ser Pro Glu Lys Ala 
            260                 265                 270         


Pro Leu Gly Gly Val Ile Leu Val His Leu Ile Ile Pro Gly Leu Asn 
        275                 280                 285             


Glu Thr Thr Val Lys Leu Pro Ala Ser Leu Met Phe Glu Ile Ser Asp 
    290                 295                 300                 


Ala Leu Lys Thr Gln Leu Ala Lys Asn Glu Thr Leu Ala Leu Pro Ala 
305                 310                 315                 320 


Glu Ser Lys Thr Pro Glu Val Glu Lys Ile Ser Ala Arg Pro Thr Thr 
                325                 330                 335     


Val Thr Pro Glu Thr Val Pro Arg Ser Thr Lys Pro Thr Thr Ser Ser 
            340                 345                 350         


Ala Leu Asp Val Ser Glu Thr Thr Leu Val Leu Ser Lys Arg Thr Pro 
        355                 360                 365             


Glu Thr Leu Gln Thr Ile Leu Ile Pro Gln Phe Glu Leu Pro Leu Ser 
    370                 375                 380                 


Thr Leu Ala Pro Lys Ser Leu Pro Glu Phe Pro Glu Ala Lys Thr Pro 
385                 390                 395                 400 


Phe Pro Phe Glu Lys Pro Arg Gly Thr Leu Ala Ser Ser Glu Lys Pro 
                405                 410                 415     


Trp Ile Val Pro Thr Ala Lys Ile Ser Glu Asp Ser Lys Val Leu Gln 
            420                 425                 430         


Pro Gln Thr Ala Thr Tyr Asp Val Phe Ser Ser Pro Thr Thr Ser Asp 
        435                 440                 445             


Glu Pro Glu Ile Ser Asp Ser Tyr Thr Ala Thr Ser Asp Arg Ile Leu 
    450                 455                 460                 


Asp Ser Ile Pro Pro Lys Thr Ser Arg Thr Leu Glu Gln Pro Arg Ala 
465                 470                 475                 480 


Thr Leu Ala Pro Ser Glu Thr Pro Phe Val Pro Gln Lys Leu Glu Ile 
                485                 490                 495     


Phe Thr Ser Pro Glu Met Gln Pro Thr Thr Pro Ala Pro Gln Gln Thr 
            500                 505                 510         


Thr Ser Ile Pro Ser Thr Pro Lys Arg Arg Pro Arg Pro Lys Pro Pro 
        515                 520                 525             


Arg Thr Lys Pro Glu Arg Thr Thr Ser Ala Gly Thr Ile Thr Pro Lys 
    530                 535                 540                 


Ile Ser Lys Ser Pro Glu Pro Thr Trp Thr Thr Pro Ala Pro Gly Lys 
545                 550                 555                 560 


Thr Gln Phe Ile Ser Leu Lys Pro Lys Ile Pro Leu Ser Pro Glu Val 
                565                 570                 575     


Thr His Thr Lys Pro Ala Pro Glu Pro Gln Thr Leu Leu Pro Ser Gln 
            580                 585                 590         


Ser Thr Ile Gly Pro Glu Thr Pro Gly Thr Lys Pro Ser Thr Thr Leu 
        595                 600                 605             


Ala Pro Arg Lys Thr Lys Arg Pro Gly Arg Arg Pro Arg Pro Arg Pro 
    610                 615                 620                 


Arg Pro Lys Thr Thr Pro Ser Pro Glu Val Pro Lys Ser Lys Pro Ala 
625                 630                 635                 640 


Leu Glu Pro Ala Thr Ile Gln Pro Glu Pro Leu Val Pro Thr Thr Ala 
                645                 650                 655     


Ser Lys Pro Ser Glu Arg Pro Lys Thr Thr His Arg Pro Asp Ala Pro 
            660                 665                 670         


Gln Ile Gln Pro Gly Ser Lys Pro Pro Lys Gln Leu Leu Pro Lys Pro 
        675                 680                 685             


Gln Thr Thr Ala Glu Pro Asp Met Pro Pro Thr Lys Ser Val Ser Glu 
    690                 695                 700                 


Pro Val Pro Phe Glu Thr Glu Ala Pro Ser Met Thr Ile Val Pro Thr 
705                 710                 715                 720 


Thr Asp Ile Glu Pro Val Thr Val Arg Thr Glu Ala Thr Val Thr Thr 
                725                 730                 735     


Leu Ala Pro Lys Thr Ser Gln Arg Thr Arg Thr Arg Arg Pro Arg Pro 
            740                 745                 750         


Lys His Lys Thr Thr Pro Arg Pro Glu Thr Leu Gln Thr Lys Leu Asp 
        755                 760                 765             


Phe Gly Pro Ile Thr Pro Gly Thr Ser Ser Ala Pro Thr Thr Thr Thr 
    770                 775                 780                 


Lys Arg Thr Arg Arg Pro His Pro Lys Pro Lys Thr Thr Pro His Pro 
785                 790                 795                 800 


Glu Val Pro Gln Thr Lys Leu Val Pro Ala Thr Ile Leu Glu Pro Val 
                805                 810                 815     


Leu Arg Thr Glu Ala Ser Gly Thr Thr Ala Ala Pro Lys Val Pro Gln 
            820                 825                 830         


Arg Thr His Arg Pro His Pro Lys Pro Lys Thr Thr Leu Ser Pro Glu 
        835                 840                 845             


Glu Leu Gln Thr Glu Leu Val Pro Ala Thr Ile Phe Glu Pro Val Ser 
    850                 855                 860                 


Pro Ile Lys Glu Ala Pro Gly Thr Thr Phe Val Pro Val Thr Asp Leu 
865                 870                 875                 880 


Glu Pro Val Thr Phe Arg Thr Glu Ile Pro Ala Thr Thr Leu Ala Thr 
                885                 890                 895     


Lys Thr Ser Lys Arg Thr Arg Pro Pro Arg Pro Arg Pro Lys Thr Thr 
            900                 905                 910         


Pro Ser Pro Gln Ala Pro Glu Thr Lys Pro Val Pro Ala Thr Val Leu 
        915                 920                 925             


Glu Pro Val Thr Leu Arg Pro Glu Ala Ser Thr Thr Leu Ala Ser Lys 
    930                 935                 940                 


Thr Ser Gln Arg Thr Arg Arg Pro Arg Leu Arg Thr Lys Thr Thr Pro 
945                 950                 955                 960 


Arg Pro Glu Ala Pro Glu Ser Lys Pro Val Pro Thr Ala Glu Leu Lys 
                965                 970                 975     


Pro Val Thr Leu Arg Thr Glu Thr Trp Val Thr Thr Gln Ala Pro Lys 
            980                 985                 990         


Thr Ser Gln Arg Thr Arg Arg Pro  Arg Pro Lys Thr Lys  Thr Thr Pro 
        995                 1000                 1005             


Ser Pro  Glu Val Pro Gln Thr  Lys Leu Val Pro Ser  Thr Asp Leu 
    1010                 1015                 1020             


Glu Pro  Gly Thr Leu Arg Thr  Glu Ala Pro Lys Thr  Met Val Val 
    1025                 1030                 1035             


Thr Thr  Val Leu Glu Pro Asp  Thr Phe Arg Thr Lys  Phe Pro Glu 
    1040                 1045                 1050             


Thr Thr  Leu Ala Pro Lys Thr  Gln Arg Thr Arg Arg  Pro Arg Pro 
    1055                 1060                 1065             


Arg Pro  Lys Thr Thr Ser Ser  Pro Glu Val Pro Gln  Asn Lys Ser 
    1070                 1075                 1080             


Val Ser  Val Thr Gly Phe Glu  Pro Val Val His Ser  Thr Asp Ala 
    1085                 1090                 1095             


Pro Gly  Thr Thr Phe Ala Leu  Thr Glu Leu Gln Thr  Leu Ile Leu 
    1100                 1105                 1110             


Lys Pro  Val Thr Ser Pro Ser  Leu Glu Met Thr Glu  Ser Gln Pro 
    1115                 1120                 1125             


Val Ser  Asp Val Leu Glu Ser  Val Thr Leu Ser Thr  Glu Ser Pro 
    1130                 1135                 1140             


Lys Glu  Thr Ile Ala Pro Ala  Lys Thr Asp Tyr Val  Tyr Pro Thr 
    1145                 1150                 1155             


Ala Lys  Ala Pro Leu Trp Pro  Glu Glu Pro Lys Thr  Glu Val Val 
    1160                 1165                 1170             


Glu Ser  Ile Thr Tyr Val Ser  Glu Pro Pro Glu Thr  Thr Leu Glu 
    1175                 1180                 1185             


Thr Ser  Pro Leu Pro Ser Gln  Ser Ile Thr Leu Pro  Ser Pro Asp 
    1190                 1195                 1200             


Glu Pro  Gln Thr Glu Pro Ala  Pro Lys Gln Thr Pro  Arg Ala Pro 
    1205                 1210                 1215             


Pro Lys  Pro Lys Thr Ser Pro  Arg Pro Arg Ile Pro  Gln Thr Gln 
    1220                 1225                 1230             


Pro Val  Pro Lys Val Pro Gln  Arg Val Thr Ala Lys  Pro Lys Thr 
    1235                 1240                 1245             


Ser Pro  Ser Pro Glu Val Ser  Tyr Thr Thr Pro Ala  Pro Lys Asp 
    1250                 1255                 1260             


Val Leu  Leu Pro His Lys Pro  Tyr Pro Glu Val Ser  Gln Ser Glu 
    1265                 1270                 1275             


Pro Ala  Pro Leu Glu Thr Arg  Gly Ile Pro Phe Ile  Pro Met Ile 
    1280                 1285                 1290             


Ser Pro  Ser Pro Ser Gln Glu  Glu Leu Gln Thr Thr  Leu Glu Glu 
    1295                 1300                 1305             


Thr Asp  Gln Ser Thr Gln Glu  Pro Phe Thr Thr Lys  Ile Pro Arg 
    1310                 1315                 1320             


Thr Thr  Glu Leu Ala Lys Thr  Thr Gln Ala Pro His  Arg Phe Tyr 
    1325                 1330                 1335             


Thr Thr  Val Arg Pro Arg Thr  Ser Asp Lys Pro His  Ile Arg Pro 
    1340                 1345                 1350             


Val Leu  Asn Arg Thr Thr Thr  Arg Pro Thr Arg Pro  Lys Pro Ser 
    1355                 1360                 1365             


Gly Met  Pro Ser Gly Asn Gly  Val Gly Thr Gly Val  Lys Gln Ala 
    1370                 1375                 1380             


Pro Arg  Pro Ser Gly Ala Asp  Arg Asn Val Ser Val  Asp Ser Thr 
    1385                 1390                 1395             


His Pro  Thr Lys Lys Pro Gly  Thr Arg Arg Pro Pro  Leu Pro Pro 
    1400                 1405                 1410             


Arg Pro  Thr His Pro Arg Arg  Lys Pro Leu Pro Pro  Asn Asn Val 
    1415                 1420                 1425             


Thr Gly  Lys Pro Gly Ser Ala  Gly Ile Ile Ser Ser  Gly Pro Ile 
    1430                 1435                 1440             


Thr Thr  Pro Pro Leu Arg Ser  Thr Pro Arg Pro Thr  Gly Thr Pro 
    1445                 1450                 1455             


Leu Glu  Arg Ile Glu Thr Asp  Ile Lys Gln Pro Thr  Val Pro Ala 
    1460                 1465                 1470             


Ser Gly  Glu Glu Leu Glu Asn  Ile Thr Asp Phe Ser  Ser Ser Pro 
    1475                 1480                 1485             


Thr Arg  Glu Thr Asp Pro Leu  Gly Lys Pro Arg Phe  Lys Gly Pro 
    1490                 1495                 1500             


His Val  Arg Tyr Ile Gln Lys  Pro Asp Asn Ser Pro  Cys Ser Ile 
    1505                 1510                 1515             


Thr Asp  Ser Val Lys Arg Phe  Pro Lys Glu Glu Ala  Thr Glu Gly 
    1520                 1525                 1530             


Asn Ala  Thr Ser Pro Pro Gln  Asn Pro Pro Thr Asn  Leu Thr Val 
    1535                 1540                 1545             


Val Thr  Val Glu Gly Cys Pro  Ser Phe Val Ile Leu  Asp Trp Glu 
    1550                 1555                 1560             


Lys Pro  Leu Asn Asp Thr Val  Thr Glu Tyr Glu Val  Ile Ser Arg 
    1565                 1570                 1575             


Glu Asn  Gly Ser Phe Ser Gly  Lys Asn Lys Ser Ile  Gln Met Thr 
    1580                 1585                 1590             


Asn Gln  Thr Phe Ser Thr Val  Glu Asn Leu Lys Pro  Asn Thr Ser 
    1595                 1600                 1605             


Tyr Glu  Phe Gln Val Lys Pro  Lys Asn Pro Leu Gly  Glu Gly Pro 
    1610                 1615                 1620             


Val Ser  Asn Thr Val Ala Phe  Ser Thr Glu Ser Ala  Asp Pro Arg 
    1625                 1630                 1635             


Val Ser  Glu Pro Val Ser Ala  Gly Arg Asp Ala Ile  Trp Thr Glu 
    1640                 1645                 1650             


Arg Pro  Phe Asn Ser Asp Ser  Tyr Ser Glu Cys Lys  Gly Lys Gln 
    1655                 1660                 1665             


Tyr Val  Lys Arg Thr Trp Tyr  Lys Lys Phe Val Gly  Val Gln Leu 
    1670                 1675                 1680             


Cys Asn  Ser Leu Arg Tyr Lys  Ile Tyr Leu Ser Asp  Ser Leu Thr 
    1685                 1690                 1695             


Gly Lys  Phe Tyr Asn Ile Gly  Asp Gln Arg Gly His  Gly Glu Asp 
    1700                 1705                 1710             


His Cys  Gln Phe Val Asp Ser  Phe Leu Asp Gly Arg  Thr Gly Gln 
    1715                 1720                 1725             


Gln Leu  Thr Ser Asp Gln Leu  Pro Ile Lys Glu Gly  Tyr Phe Arg 
    1730                 1735                 1740             


Ala Val  Arg Gln Glu Pro Val  Gln Phe Gly Glu Ile  Gly Gly His 
    1745                 1750                 1755             


Thr Gln  Ile Asn Tyr Val Gln  Trp Tyr Glu Cys Gly  Thr Thr Ile 
    1760                 1765                 1770             


Pro Gly  Lys Trp 
    1775         


<210>  47
<211>  1005
<212>  PRT
<213>  Homo Sapiens

<400>  47

Met Arg Gly Gly Lys Cys Asn Met Leu Ser Ser Leu Gly Cys Leu Leu 
1               5                   10                  15      


Leu Cys Gly Ser Ile Thr Leu Ala Leu Gly Asn Ala Gln Lys Leu Pro 
            20                  25                  30          


Lys Gly Lys Arg Pro Asn Leu Lys Val His Ile Asn Thr Thr Ser Asp 
        35                  40                  45              


Ser Ile Leu Leu Lys Phe Leu Arg Pro Ser Pro Asn Val Lys Leu Glu 
    50                  55                  60                  


Gly Leu Leu Leu Gly Tyr Gly Ser Asn Val Ser Pro Asn Gln Tyr Phe 
65                  70                  75                  80  


Pro Leu Pro Ala Glu Gly Lys Phe Thr Glu Ala Ile Val Asp Ala Glu 
                85                  90                  95      


Pro Lys Tyr Leu Ile Val Val Arg Pro Ala Pro Pro Pro Ser Gln Lys 
            100                 105                 110         


Lys Ser Cys Ser Gly Lys Thr Arg Ser Arg Lys Pro Leu Gln Leu Val 
        115                 120                 125             


Val Gly Thr Leu Thr Pro Ser Ser Val Phe Leu Ser Trp Gly Phe Leu 
    130                 135                 140                 


Ile Asn Pro His His Asp Trp Thr Leu Pro Ser His Cys Pro Asn Asp 
145                 150                 155                 160 


Arg Phe Tyr Thr Ile Arg Tyr Arg Glu Lys Asp Lys Glu Lys Lys Trp 
                165                 170                 175     


Ile Phe Gln Ile Cys Pro Ala Thr Glu Thr Ile Val Glu Asn Leu Lys 
            180                 185                 190         


Pro Asn Thr Val Tyr Glu Phe Gly Val Lys Asp Asn Val Glu Gly Gly 
        195                 200                 205             


Ile Trp Ser Lys Ile Phe Asn His Lys Thr Val Val Gly Ser Lys Lys 
    210                 215                 220                 


Val Asn Gly Lys Ile Gln Ser Thr Tyr Asp Gln Asp His Thr Val Pro 
225                 230                 235                 240 


Ala Tyr Val Pro Arg Lys Leu Ile Pro Ile Thr Ile Ile Lys Gln Val 
                245                 250                 255     


Ile Gln Asn Val Thr His Lys Asp Ser Ala Lys Ser Pro Glu Lys Ala 
            260                 265                 270         


Pro Leu Gly Gly Val Ile Leu Val His Leu Ile Ile Pro Gly Leu Asn 
        275                 280                 285             


Glu Thr Thr Val Lys Leu Pro Ala Ser Leu Met Phe Glu Ile Ser Asp 
    290                 295                 300                 


Ala Leu Lys Thr Gln Leu Ala Lys Asn Glu Thr Leu Ala Leu Pro Ala 
305                 310                 315                 320 


Glu Ser Lys Thr Pro Glu Val Glu Lys Ile Ser Ala Arg Pro Thr Thr 
                325                 330                 335     


Val Thr Pro Glu Thr Val Pro Arg Ser Thr Lys Pro Thr Thr Ser Ser 
            340                 345                 350         


Ala Leu Asp Val Ser Glu Thr Thr Leu Val Leu Ser Lys Arg Thr Pro 
        355                 360                 365             


Glu Thr Leu Gln Thr Ile Leu Ile Pro Gln Phe Glu Leu Pro Leu Ser 
    370                 375                 380                 


Thr Leu Ala Pro Lys Ser Leu Pro Glu Phe Pro Glu Ala Lys Thr Pro 
385                 390                 395                 400 


Phe Pro Phe Glu Lys Pro Arg Gly Thr Leu Ala Ser Ser Glu Lys Pro 
                405                 410                 415     


Trp Ile Val Pro Thr Ala Lys Ile Ser Glu Asp Ser Lys Val Leu Gln 
            420                 425                 430         


Pro Gln Thr Ala Thr Tyr Asp Val Phe Ser Ser Pro Thr Thr Ser Asp 
        435                 440                 445             


Glu Pro Glu Ile Ser Asp Ser Tyr Thr Ala Thr Ser Asp Arg Ile Leu 
    450                 455                 460                 


Asp Ser Ile Pro Pro Lys Thr Ser Arg Thr Leu Glu Gln Pro Arg Ala 
465                 470                 475                 480 


Thr Leu Ala Pro Ser Glu Thr Pro Phe Val Pro Gln Lys Leu Glu Ile 
                485                 490                 495     


Phe Thr Ser Pro Glu Met Gln Pro Thr Thr Pro Ala Pro Gln Gln Thr 
            500                 505                 510         


Thr Ser Ile Pro Ser Thr Pro Lys Arg Arg Pro Arg Pro Lys Pro Pro 
        515                 520                 525             


Arg Thr Lys Pro Glu Arg Thr Thr Ser Ala Gly Thr Ile Thr Pro Lys 
    530                 535                 540                 


Ile Ser Lys Ser Pro Glu Pro Thr Trp Thr Thr Pro Ala Pro Gly Lys 
545                 550                 555                 560 


Thr Gln Phe Ile Ser Leu Lys Pro Lys Ile Pro Leu Ser Pro Glu Val 
                565                 570                 575     


Thr His Thr Lys Pro Ala Pro Glu Pro Gln Thr Leu Leu Pro Ser Gln 
            580                 585                 590         


Ser Thr Ile Gly Pro Glu Thr Pro Gly Thr Lys Pro Ser Thr Thr Leu 
        595                 600                 605             


Ala Pro Arg Lys Thr Lys Arg Pro Gly Arg Arg Pro Arg Pro Arg Pro 
    610                 615                 620                 


Arg Pro Lys Thr Thr Pro Ser Pro Glu Val Pro Lys Ser Lys Pro Ala 
625                 630                 635                 640 


Leu Glu Pro Ala Thr Ile Gln Pro Glu Pro Leu Val Pro Thr Thr Ala 
                645                 650                 655     


Ser Lys Pro Ser Glu Arg Pro Lys Thr Thr His Arg Pro Asp Ala Pro 
            660                 665                 670         


Gln Ile Gln Pro Gly Ser Lys Pro Pro Lys Gln Leu Leu Pro Lys Pro 
        675                 680                 685             


Gln Thr Thr Ala Glu Pro Asp Met Pro Pro Thr Lys Ser Val Ser Glu 
    690                 695                 700                 


Pro Val Pro Phe Glu Thr Glu Ala Pro Ser Met Thr Ile Val Pro Thr 
705                 710                 715                 720 


Thr Asp Ile Glu Pro Val Thr Val Arg Thr Glu Ala Thr Val Thr Thr 
                725                 730                 735     


Leu Ala Pro Lys Thr Ser Gln Arg Thr Arg Thr Arg Arg Pro Arg Pro 
            740                 745                 750         


Lys His Lys Thr Thr Pro Arg Pro Glu Thr Leu Gln Thr Lys Leu Asp 
        755                 760                 765             


Phe Gly Pro Ile Thr Pro Gly Thr Ser Ser Ala Pro Thr Thr Thr Thr 
    770                 775                 780                 


Lys Arg Thr Arg Arg Pro His Pro Lys Pro Lys Thr Thr Pro His Pro 
785                 790                 795                 800 


Glu Val Pro Gln Thr Lys Leu Ala Thr Lys Thr Ser Lys Arg Thr Arg 
                805                 810                 815     


Pro Pro Arg Pro Arg Pro Lys Thr Thr Pro Ser Pro Gln Ala Pro Glu 
            820                 825                 830         


Thr Lys Pro Val Pro Ala Thr Val Leu Glu Pro Val Thr Leu Arg Pro 
        835                 840                 845             


Glu Ala Ser Thr Thr Leu Ala Ser Lys Thr Ser Gln Arg Thr Arg Arg 
    850                 855                 860                 


Pro Arg Leu Arg Thr Lys Thr Thr Pro Arg Pro Glu Ala Pro Glu Ser 
865                 870                 875                 880 


Lys Pro Val Pro Thr Ala Glu Leu Lys Pro Val Thr Leu Arg Thr Glu 
                885                 890                 895     


Thr Trp Val Thr Thr Gln Ala Pro Lys Thr Ser Gln Arg Thr Arg Arg 
            900                 905                 910         


Pro Arg Pro Lys Thr Lys Thr Thr Pro Ser Pro Glu Val Pro Gln Thr 
        915                 920                 925             


Lys Leu Val Pro Ser Thr Asp Leu Glu Pro Gly Thr Leu Arg Thr Glu 
    930                 935                 940                 


Ala Pro Lys Thr Met Val Val Thr Thr Val Leu Glu Pro Asp Thr Phe 
945                 950                 955                 960 


Arg Thr Lys Phe Pro Glu Thr Thr Leu Ala Pro Lys Thr Gln Arg Thr 
                965                 970                 975     


Arg Arg Pro Arg Pro Arg Pro Lys Thr Thr Ser Ser Pro Glu Val Pro 
            980                 985                 990         


Gln Asn Lys Ser Gly Lys Cys Met  Asn Pro Trp Leu Lys  
        995                 1000                 1005 


<210>  48
<211>  188
<212>  PRT
<213>  Homo Sapiens

<400>  48

Pro Arg Lys Thr Lys Arg Pro Gly Arg Arg Pro Arg Pro Arg Pro Arg 
1               5                   10                  15      


Pro Lys Thr Thr Pro Ser Pro Glu Val Pro Lys Ser Lys Pro Ala Leu 
            20                  25                  30          


Glu Pro Ala Thr Ile Gln Pro Glu Pro Leu Val Pro Thr Thr Ala Ser 
        35                  40                  45              


Lys Pro Ser Glu Arg Pro Lys Thr Thr His Arg Pro Asp Ala Pro Gln 
    50                  55                  60                  


Ile Gln Pro Val Ser Glu Pro Val Pro Phe Glu Thr Glu Ala Pro Ser 
65                  70                  75                  80  


Met Thr Ile Val Pro Thr Thr Asp Ile Glu Pro Val Thr Val Arg Thr 
                85                  90                  95      


Glu Ala Thr Val Thr Thr Leu Ala Pro Lys Thr Ser Gln Arg Thr Arg 
            100                 105                 110         


Thr Arg Arg Pro Arg Pro Lys His Lys Thr Thr Pro Arg Pro Glu Thr 
        115                 120                 125             


Leu Gln Thr Lys Leu Asp Phe Gly Pro Ile Thr Pro Gly Thr Ser Ser 
    130                 135                 140                 


Ala Pro Thr Thr Thr Thr Lys Arg Thr Arg Arg Pro His Pro Lys Pro 
145                 150                 155                 160 


Lys Thr Thr Pro His Pro Glu Val Pro Gln Thr Lys Leu Ala Pro Lys 
                165                 170                 175     


Gln Thr Pro Arg Ala Pro Pro Lys Pro Lys Thr Ser 
            180                 185             


<210>  49
<211>  233
<212>  PRT
<213>  Homo Sapiens

<400>  49

Gln Arg Val Thr Ala Lys Pro Lys Thr Ser Pro Ser Pro Glu Val Ser 
1               5                   10                  15      


Tyr Thr Thr Pro Ala Pro Lys Asp Val Leu Leu Pro His Lys Pro Tyr 
            20                  25                  30          


Pro Glu Val Ser Gln Ser Glu Pro Ala Pro Leu Glu Thr Arg Gly Ile 
        35                  40                  45              


Pro Phe Ile Pro Met Ile Ser Pro Ser Pro Ser Gln Glu Glu Leu Gln 
    50                  55                  60                  


Thr Thr Leu Ala Pro His Arg Phe Tyr Thr Thr Val Arg Pro Arg Thr 
65                  70                  75                  80  


Ser Asp Lys Pro His Ile Arg Pro Gly Val Lys Gln Ala Pro Arg Pro 
                85                  90                  95      


Ser Gly Ala Asp Arg Asn Val Ser Val Asp Ser Thr His Pro Thr Lys 
            100                 105                 110         


Lys Pro Gly Thr Arg Arg Pro Pro Leu Pro Pro Arg Pro Thr His Pro 
        115                 120                 125             


Arg Arg Lys Pro Leu Pro Pro Asn Asn Val Thr Gly Lys Pro Gly Ser 
    130                 135                 140                 


Ala Gly Ile Ile Ser Ser Gly Pro Ile Thr Thr Pro Pro Leu Arg Ser 
145                 150                 155                 160 


Thr Pro Arg Pro Thr Gly Thr Pro Leu Glu Arg Ile Glu Thr Asp Ile 
                165                 170                 175     


Lys Gln Pro Thr Val Pro Ala Ser Gly Glu Glu Leu Glu Asn Ile Thr 
            180                 185                 190         


Asp Phe Ser Ser Ser Pro Thr Arg Glu Thr Asp Pro Leu Gly Lys Pro 
        195                 200                 205             


Arg Phe Lys Gly Pro His Val Arg Tyr Ile Gln Lys Pro Asp Asn Ser 
    210                 215                 220                 


Pro Cys Ser Ile Thr Asp Ser Val Lys 
225                 230             


<210>  50
<211>  158
<212>  PRT
<213>  Homo Sapiens

<400>  50

Val Ser Asp Val Leu Glu Ser Val Thr Leu Ser Thr Glu Ser Pro Lys 
1               5                   10                  15      


Glu Thr Ile Ala Pro Ala Lys Thr Asp Tyr Val Tyr Pro Thr Ala Lys 
            20                  25                  30          


Ala Pro Leu Trp Pro Glu Glu Pro Lys Thr Glu Val Val Glu Ser Ile 
        35                  40                  45              


Thr Tyr Val Ser Glu Pro Pro Glu Thr Thr Leu Glu Thr Ser Pro Leu 
    50                  55                  60                  


Pro Ser Gln Ser Ile Thr Leu Pro Ser Pro Asp Glu Pro Gln Thr Glu 
65                  70                  75                  80  


Pro Ala Pro Lys Gln Thr Pro Arg Ala Pro Pro Lys Pro Lys Thr Ser 
                85                  90                  95      


Pro Arg Pro Arg Ile Pro Gln Thr Gln Pro Val Pro Lys Val Pro Gln 
            100                 105                 110         


Arg Val Thr Ala Lys Pro Lys Thr Ser Pro Ser Pro Glu Val Ser Tyr 
        115                 120                 125             


Thr Thr Pro Ala Pro Leu Glu Thr Arg Gly Ile Pro Phe Ile Pro Met 
    130                 135                 140                 


Ile Ser Pro Ser Pro Ser Gln Glu Glu Leu Gln Thr Thr Leu 
145                 150                 155             


<210>  51
<211>  84
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  51

Xaa Phe Glu Lys Pro Arg Gly Thr Leu Ala Ser Ser Glu Lys Pro Trp 
1               5                   10                  15      


Ile Val Pro Thr Ala Lys Ile Ser Glu Asp Ser Lys Val Leu Gln Pro 
            20                  25                  30          


Gln Thr Ala Thr Ser Asp Arg Ile Leu Asp Ser Ile Pro Pro Lys Thr 
        35                  40                  45              


Ser Arg Thr Leu Glu Gln Pro Arg Ala Thr Leu Ala Pro Ser Glu Thr 
    50                  55                  60                  


Pro Phe Val Pro Gln Lys Leu Glu Ile Phe Thr Ser Pro Glu Met Gln 
65                  70                  75                  80  


Pro Thr Thr Pro 
                


<210>  52
<211>  187
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  52

Xaa Phe Ile Ser Leu Lys Pro Lys Ile Pro Leu Ser Pro Glu Val Thr 
1               5                   10                  15      


His Thr Lys Pro Ala Pro Lys Thr Ser Gln Arg Thr Arg Thr Arg Arg 
            20                  25                  30          


Pro Arg Pro Lys His Lys Thr Thr Pro Arg Pro Glu Thr Leu Gln Thr 
        35                  40                  45              


Lys Leu Asp Phe Gly Pro Ile Thr Pro Gly Thr Ser Ser Ala Pro Thr 
    50                  55                  60                  


Thr Thr Thr Lys Arg Thr Arg Arg Pro His Pro Lys Pro Lys Thr Thr 
65                  70                  75                  80  


Pro His Pro Glu Val Pro Gln Thr Lys Leu Ala Pro Lys Gln Thr Pro 
                85                  90                  95      


Arg Ala Pro Pro Lys Pro Lys Thr Ser Pro Arg Pro Arg Ile Pro Gln 
            100                 105                 110         


Thr Gln Pro Val Pro Lys Val Pro Gln Arg Val Thr Ala Lys Pro Lys 
        115                 120                 125             


Thr Ser Pro Ser Pro Glu Val Ser Tyr Thr Thr Pro Ala Pro Lys Asp 
    130                 135                 140                 


Val Leu Leu Pro His Lys Pro Tyr Pro Glu Val Ser Gln Ser Glu Pro 
145                 150                 155                 160 


Ala Pro Leu Glu Thr Arg Gly Ile Pro Phe Ile Pro Met Ile Ser Pro 
                165                 170                 175     


Ser Pro Ser Gln Glu Glu Leu Gln Thr Thr Leu 
            180                 185         


<210>  53
<211>  1131
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  53

Xaa Ile Ser Leu Lys Pro Lys Ile Pro Leu Ser Pro Glu Val Thr His 
1               5                   10                  15      


Thr Lys Pro Ala Pro Glu Pro Gln Thr Leu Leu Pro Ser Gln Ser Thr 
            20                  25                  30          


Ile Gly Pro Glu Thr Pro Gly Thr Lys Pro Ser Thr Thr Leu Ala Leu 
        35                  40                  45              


Glu Pro Ala Thr Ile Gln Pro Glu Pro Leu Val Pro Thr Thr Ala Ser 
    50                  55                  60                  


Lys Pro Ser Glu Arg Pro Lys Thr Thr His Arg Pro Asp Ala Pro Gln 
65                  70                  75                  80  


Ile Gln Pro Gly Ser Lys Pro Pro Lys Gln Leu Leu Pro Lys Pro Gln 
                85                  90                  95      


Thr Thr Ala Glu Pro Asp Met Pro Pro Thr Lys Ser Val Ser Glu Pro 
            100                 105                 110         


Val Pro Phe Glu Thr Glu Ala Pro Ser Met Thr Ile Val Pro Thr Thr 
        115                 120                 125             


Asp Ile Glu Pro Val Thr Val Arg Thr Glu Ala Thr Val Thr Thr Leu 
    130                 135                 140                 


Ala Pro Lys Thr Ser Gln Arg Thr Arg Thr Arg Arg Pro Arg Pro Lys 
145                 150                 155                 160 


His Lys Thr Thr Pro Arg Pro Glu Thr Leu Gln Thr Lys Leu Asp Phe 
                165                 170                 175     


Gly Pro Ile Thr Pro Gly Thr Ser Ser Ala Pro Thr Thr Thr Thr Lys 
            180                 185                 190         


Arg Thr Arg Arg Pro His Pro Lys Pro Lys Thr Thr Pro His Pro Glu 
        195                 200                 205             


Val Pro Gln Thr Lys Leu Val Pro Ala Thr Ile Leu Glu Pro Val Leu 
    210                 215                 220                 


Arg Thr Glu Ala Ser Gly Thr Thr Ala Val Pro Ala Thr Ile Phe Glu 
225                 230                 235                 240 


Pro Val Ser Pro Ile Lys Glu Ala Pro Gly Thr Thr Phe Val Pro Val 
                245                 250                 255     


Thr Asp Leu Glu Pro Val Thr Phe Arg Thr Glu Ile Pro Ala Thr Thr 
            260                 265                 270         


Leu Ala Thr Lys Thr Ser Lys Arg Thr Arg Pro Pro Arg Pro Arg Pro 
        275                 280                 285             


Lys Thr Thr Pro Ser Pro Gln Ala Pro Glu Thr Lys Pro Val Pro Ala 
    290                 295                 300                 


Thr Val Leu Glu Pro Val Thr Leu Arg Pro Glu Ala Ser Thr Thr Leu 
305                 310                 315                 320 


Ala Ser Lys Thr Ser Gln Arg Thr Arg Arg Pro Arg Leu Arg Thr Lys 
                325                 330                 335     


Thr Thr Pro Arg Pro Glu Ala Pro Glu Ser Lys Pro Val Pro Thr Ala 
            340                 345                 350         


Glu Leu Lys Pro Val Thr Leu Arg Thr Glu Thr Trp Val Thr Thr Gln 
        355                 360                 365             


Ala Pro Lys Thr Ser Gln Arg Thr Arg Arg Pro Arg Pro Lys Thr Lys 
    370                 375                 380                 


Thr Thr Pro Ser Pro Glu Val Pro Gln Thr Lys Leu Val Pro Ser Thr 
385                 390                 395                 400 


Asp Leu Glu Pro Gly Thr Leu Arg Thr Glu Ala Pro Lys Thr Met Val 
                405                 410                 415     


Val Thr Thr Val Leu Glu Pro Asp Thr Phe Arg Thr Lys Phe Pro Glu 
            420                 425                 430         


Thr Thr Leu Ala Pro Lys Thr Gln Arg Thr Arg Arg Pro Arg Pro Arg 
        435                 440                 445             


Pro Lys Thr Thr Ser Ser Pro Glu Val Pro Gln Asn Lys Ser Val Ser 
    450                 455                 460                 


Val Thr Gly Phe Glu Pro Val Val His Ser Thr Asp Ala Pro Gly Thr 
465                 470                 475                 480 


Thr Phe Ala Leu Thr Glu Leu Gln Thr Leu Ile Leu Lys Pro Val Thr 
                485                 490                 495     


Ser Pro Ser Leu Glu Met Thr Glu Ser Gln Pro Val Ser Asp Val Leu 
            500                 505                 510         


Glu Ser Val Thr Leu Ser Thr Glu Ser Pro Lys Glu Thr Ile Ala Pro 
        515                 520                 525             


Ala Lys Thr Asp Tyr Val Tyr Pro Thr Ala Lys Ala Pro Leu Trp Pro 
    530                 535                 540                 


Glu Glu Pro Lys Thr Glu Val Val Glu Ser Ile Thr Tyr Val Ser Glu 
545                 550                 555                 560 


Pro Pro Glu Thr Thr Leu Glu Thr Ser Pro Leu Pro Ser Gln Ser Ile 
                565                 570                 575     


Thr Leu Pro Ser Pro Asp Glu Pro Gln Thr Glu Pro Ala Pro Lys Gln 
            580                 585                 590         


Thr Pro Arg Ala Pro Pro Lys Pro Lys Thr Ser Pro Arg Pro Arg Ile 
        595                 600                 605             


Pro Gln Thr Gln Pro Val Pro Lys Val Pro Gln Arg Val Thr Ala Lys 
    610                 615                 620                 


Pro Lys Thr Ser Pro Ser Pro Glu Val Ser Tyr Thr Thr Pro Ala Pro 
625                 630                 635                 640 


Lys Asp Val Leu Leu Pro His Lys Pro Tyr Pro Glu Val Ser Gln Ser 
                645                 650                 655     


Glu Pro Ala Pro Leu Glu Thr Arg Gly Ile Pro Phe Ile Pro Met Ile 
            660                 665                 670         


Ser Pro Ser Pro Ser Gln Glu Glu Leu Gln Thr Thr Leu Glu Glu Thr 
        675                 680                 685             


Asp Gln Ser Thr Gln Glu Pro Phe Thr Thr Lys Ile Pro Arg Thr Thr 
    690                 695                 700                 


Glu Leu Ala Lys Thr Thr Gln Ala Pro His Arg Phe Tyr Thr Thr Val 
705                 710                 715                 720 


Arg Pro Arg Thr Ser Asp Lys Pro His Ile Arg Pro Gly Val Lys Gln 
                725                 730                 735     


Ala Pro Arg Pro Ser Gly Ala Asp Arg Asn Val Ser Val Asp Ser Thr 
            740                 745                 750         


His Pro Thr Lys Lys Pro Gly Thr Arg Arg Pro Pro Leu Pro Pro Arg 
        755                 760                 765             


Pro Thr His Pro Arg Arg Lys Pro Leu Pro Pro Asn Asn Val Thr Gly 
    770                 775                 780                 


Lys Pro Gly Ser Ala Gly Ile Ile Ser Ser Gly Pro Ile Thr Thr Pro 
785                 790                 795                 800 


Pro Leu Arg Ser Thr Pro Arg Pro Thr Gly Thr Pro Leu Glu Arg Ile 
                805                 810                 815     


Glu Thr Asp Ile Lys Gln Pro Thr Val Pro Ala Ser Gly Glu Glu Leu 
            820                 825                 830         


Glu Asn Ile Thr Asp Phe Ser Ser Ser Pro Thr Arg Glu Thr Asp Pro 
        835                 840                 845             


Leu Gly Lys Pro Arg Phe Lys Gly Pro His Val Arg Tyr Ile Gln Lys 
    850                 855                 860                 


Pro Asp Asn Ser Pro Cys Ser Ile Thr Asp Ser Val Lys Arg Phe Pro 
865                 870                 875                 880 


Lys Glu Glu Ala Thr Glu Gly Asn Ala Thr Ser Pro Pro Gln Asn Pro 
                885                 890                 895     


Pro Thr Asn Leu Thr Val Val Thr Val Glu Gly Cys Pro Ser Phe Val 
            900                 905                 910         


Ile Leu Asp Trp Glu Lys Pro Leu Asn Asp Thr Val Thr Glu Tyr Glu 
        915                 920                 925             


Val Ile Ser Arg Glu Asn Gly Ser Phe Ser Gly Lys Asn Lys Ser Ile 
    930                 935                 940                 


Gln Met Thr Asn Gln Thr Phe Ser Thr Val Glu Asn Leu Lys Pro Asn 
945                 950                 955                 960 


Thr Ser Tyr Glu Phe Gln Val Lys Pro Lys Asn Pro Leu Gly Glu Gly 
                965                 970                 975     


Pro Val Ser Asn Thr Val Ala Phe Ser Thr Glu Ser Ala Asp Pro Arg 
            980                 985                 990         


Val Ser Glu Pro Val Ser Ala Gly  Arg Asp Ala Ile Trp  Thr Glu Arg 
        995                 1000                 1005             


Pro Phe  Asn Ser Asp Ser Tyr  Ser Glu Cys Lys Gly  Lys Gln Tyr 
    1010                 1015                 1020             


Val Lys  Arg Thr Trp Tyr Lys  Lys Phe Val Gly Val  Gln Leu Cys 
    1025                 1030                 1035             


Asn Ser  Leu Arg Tyr Lys Ile  Tyr Leu Ser Asp Ser  Leu Thr Gly 
    1040                 1045                 1050             


Lys Phe  Tyr Asn Ile Gly Asp  Gln Arg Gly His Gly  Glu Asp His 
    1055                 1060                 1065             


Cys Gln  Phe Val Asp Ser Phe  Leu Asp Gly Arg Thr  Gly Gln Gln 
    1070                 1075                 1080             


Leu Thr  Ser Asp Gln Leu Pro  Ile Lys Glu Gly Tyr  Phe Arg Ala 
    1085                 1090                 1095             


Val Arg  Gln Glu Pro Val Gln  Phe Gly Glu Ile Gly  Gly His Thr 
    1100                 1105                 1110             


Gln Ile  Asn Tyr Val Gln Trp  Tyr Glu Cys Gly Thr  Thr Ile Pro 
    1115                 1120                 1125             


Gly Lys  Trp 
    1130     


<210>  54
<211>  125
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  54

Xaa Lys Asn Glu Thr Leu Ala Leu Pro Ala Glu Ser Lys Thr Pro Glu 
1               5                   10                  15      


Val Glu Lys Ile Ser Ala Arg Pro Thr Thr Val Thr Pro Glu Thr Val 
            20                  25                  30          


Pro Arg Ser Thr Lys Pro Thr Thr Ser Ser Ala Leu Asp Val Ser Glu 
        35                  40                  45              


Thr Thr Leu Ala Pro Lys Ser Leu Pro Glu Phe Pro Glu Ala Lys Thr 
    50                  55                  60                  


Pro Phe Pro Phe Glu Lys Pro Arg Gly Thr Leu Ala Ser Ser Glu Lys 
65                  70                  75                  80  


Pro Trp Ile Val Pro Thr Ala Lys Ile Ser Glu Asp Ser Lys Val Leu 
                85                  90                  95      


Gln Pro Gln Thr Ala Leu Thr Glu Leu Gln Thr Leu Ile Leu Lys Pro 
            100                 105                 110         


Val Thr Ser Pro Ser Leu Glu Met Thr Glu Ser Gln Pro 
        115                 120                 125 


<210>  55
<211>  187
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  55

Xaa Lys Thr Thr Pro His Pro Glu Val Pro Gln Thr Lys Leu Ala Pro 
1               5                   10                  15      


Lys Val Pro Gln Arg Thr His Arg Pro His Pro Lys Pro Lys Thr Thr 
            20                  25                  30          


Leu Ser Pro Glu Glu Leu Gln Thr Glu Leu Val Pro Ala Thr Ile Phe 
        35                  40                  45              


Glu Pro Val Ser Pro Ile Lys Glu Ala Pro Gly Thr Thr Phe Val Pro 
    50                  55                  60                  


Val Thr Asp Leu Glu Pro Val Thr Phe Arg Thr Glu Ile Pro Ala Thr 
65                  70                  75                  80  


Thr Leu Ala Thr Lys Thr Ser Lys Arg Thr Arg Pro Pro Arg Pro Arg 
                85                  90                  95      


Pro Lys Thr Thr Pro Ser Pro Gln Ala Pro Glu Thr Lys Pro Ala Pro 
            100                 105                 110         


Lys Gln Thr Pro Arg Ala Pro Pro Lys Pro Lys Thr Ser Pro Arg Pro 
        115                 120                 125             


Arg Ile Pro Gln Thr Gln Pro Val Pro Lys Val Pro Gln Arg Val Thr 
    130                 135                 140                 


Ala Lys Pro Lys Thr Ser Pro Ser Pro Glu Val Ser Tyr Thr Thr Pro 
145                 150                 155                 160 


Ala Pro Leu Glu Thr Arg Gly Ile Pro Phe Ile Pro Met Ile Ser Pro 
                165                 170                 175     


Ser Pro Ser Gln Glu Glu Leu Gln Thr Thr Leu 
            180                 185         


<210>  56
<211>  187
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  56

Xaa Asn Gly Lys Ile Gln Ser Thr Tyr Asp Gln Asp His Thr Val Pro 
1               5                   10                  15      


Ala Tyr Val Pro Arg Lys Leu Ile Pro Ile Thr Ile Ile Lys Gln Val 
            20                  25                  30          


Ile Gln Asn Val Thr His Lys Asp Ser Ala Lys Ser Pro Glu Lys Ala 
        35                  40                  45              


Pro Leu Gly Gly Val Ile Leu Val His Leu Ile Ile Pro Gly Leu Asn 
    50                  55                  60                  


Glu Thr Thr Val Lys Leu Pro Ala Ser Leu Met Phe Glu Ile Ser Asp 
65                  70                  75                  80  


Ala Leu Lys Thr Gln Leu Ala Lys Asn Glu Thr Leu Ala Leu Pro Ala 
                85                  90                  95      


Glu Ser Lys Thr Pro Glu Val Glu Lys Ile Ser Ala Arg Pro Thr Thr 
            100                 105                 110         


Val Thr Pro Glu Thr Val Pro Arg Ser Thr Lys Pro Thr Thr Ser Ser 
        115                 120                 125             


Ala Leu Asp Val Ser Glu Thr Thr Leu Val Leu Ser Lys Arg Thr Pro 
    130                 135                 140                 


Glu Thr Leu Gln Thr Ile Leu Ile Pro Gln Phe Glu Leu Pro Leu Ser 
145                 150                 155                 160 


Thr Leu Ala Ser Ser Glu Lys Pro Trp Ile Val Pro Thr Ala Lys Ile 
                165                 170                 175     


Ser Glu Asp Ser Lys Val Leu Gln Pro Gln Thr 
            180                 185         


<210>  57
<211>  150
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  57

Xaa Pro Glu Thr Pro Gly Thr Lys Pro Ser Thr Thr Leu Ala Pro Arg 
1               5                   10                  15      


Lys Thr Lys Arg Pro Gly Arg Arg Pro Arg Pro Arg Pro Arg Pro Lys 
            20                  25                  30          


Thr Thr Pro Ser Pro Glu Val Pro Lys Ser Lys Pro Ala Leu Glu Pro 
        35                  40                  45              


Ala Thr Ile Gln Pro Glu Pro Leu Val Pro Thr Thr Val Pro Thr Thr 
    50                  55                  60                  


Asp Ile Glu Pro Val Thr Val Arg Thr Glu Ala Thr Val Thr Thr Leu 
65                  70                  75                  80  


Ala Pro Lys Thr Ser Gln Arg Thr Arg Thr Arg Arg Pro Arg Pro Lys 
                85                  90                  95      


His Lys Thr Thr Pro Arg Pro Glu Thr Leu Gln Thr Lys Leu Asp Phe 
            100                 105                 110         


Gly Pro Ile Thr Pro Gly Thr Ser Ser Ala Pro Thr Thr Thr Thr Lys 
        115                 120                 125             


Arg Thr Arg Arg Pro His Pro Lys Pro Lys Thr Thr Pro His Pro Glu 
    130                 135                 140                 


Val Pro Gln Thr Lys Leu 
145                 150 


<210>  58
<211>  308
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  58

Xaa Pro Lys Pro Lys Thr Thr Pro His Pro Glu Val Pro Gln Thr Lys 
1               5                   10                  15      


Leu Ala Thr Lys Thr Ser Lys Arg Thr Arg Pro Pro Arg Pro Arg Pro 
            20                  25                  30          


Lys Thr Thr Pro Ser Pro Gln Ala Pro Glu Thr Lys Pro Val Pro Ala 
        35                  40                  45              


Thr Val Leu Glu Pro Val Thr Leu Arg Pro Glu Ala Ser Thr Thr Leu 
    50                  55                  60                  


Ala Ser Lys Thr Ser Gln Arg Thr Arg Arg Pro Arg Leu Arg Thr Lys 
65                  70                  75                  80  


Thr Thr Pro Arg Pro Glu Ala Pro Glu Ser Lys Pro Val Pro Thr Ala 
                85                  90                  95      


Glu Leu Lys Pro Val Thr Leu Arg Thr Glu Thr Trp Val Thr Thr Gln 
            100                 105                 110         


Ala Pro Lys Gln Thr Pro Arg Ala Pro Pro Lys Pro Lys Thr Ser Pro 
        115                 120                 125             


Arg Pro Arg Ile Pro Gln Thr Gln Pro Val Pro Lys Val Pro Gln Arg 
    130                 135                 140                 


Val Thr Ala Lys Pro Lys Thr Ser Pro Ser Pro Glu Val Ser Tyr Thr 
145                 150                 155                 160 


Thr Pro Ala Pro Lys Asp Val Leu Leu Pro His Lys Pro Tyr Pro Glu 
                165                 170                 175     


Val Ser Gln Ser Glu Pro Ala Pro Leu Glu Thr Arg Gly Ile Pro Phe 
            180                 185                 190         


Ile Pro Met Ile Ser Pro Ser Pro Ser Gln Glu Glu Leu Gln Thr Thr 
        195                 200                 205             


Leu Glu Glu Thr Asp Gln Ser Thr Gln Glu Pro Phe Thr Thr Lys Ile 
    210                 215                 220                 


Pro Arg Thr Thr Glu Leu Ala Lys Thr Thr Gln Ala Pro His Arg Phe 
225                 230                 235                 240 


Tyr Thr Thr Val Arg Pro Arg Thr Ser Asp Lys Pro His Ile Arg Pro 
                245                 250                 255     


Val Leu Asn Arg Thr Thr Thr Arg Pro Thr Arg Pro Lys Pro Ser Gly 
            260                 265                 270         


Met Pro Ser Gly Asn Gly Val Gly Thr Gly Val Lys Gln Ala Pro Arg 
        275                 280                 285             


Pro Ser Gly Ala Asp Arg Asn Val Ser Val Asp Ser Thr His Pro Thr 
    290                 295                 300                 


Lys Lys Pro Gly 
305             


<210>  59
<211>  87
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  59

Xaa Gln Thr Leu Leu Pro Ser Gln Ser Thr Ile Gly Pro Glu Thr Pro 
1               5                   10                  15      


Gly Thr Lys Pro Ser Thr Thr Leu Ala Pro Arg Lys Thr Lys Arg Pro 
            20                  25                  30          


Gly Arg Arg Pro Arg Pro Arg Pro Arg Pro Lys Thr Thr Pro Ser Pro 
        35                  40                  45              


Glu Val Pro Lys Ser Lys Pro Ala Leu Glu Pro Ala Thr Ile Gln Pro 
    50                  55                  60                  


Glu Pro Leu Val Pro Thr Thr Val Ser Glu Pro Val Pro Phe Glu Thr 
65                  70                  75                  80  


Glu Ala Pro Ser Met Thr Ile 
                85          


<210>  60
<211>  187
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  60

Xaa Arg Thr Thr Ser Ala Gly Thr Ile Thr Pro Lys Ile Ser Lys Ser 
1               5                   10                  15      


Pro Glu Pro Thr Trp Thr Thr Pro Ala Pro Gly Lys Thr Gln Phe Ile 
            20                  25                  30          


Ser Leu Lys Pro Lys Ile Pro Leu Ser Pro Glu Val Thr His Thr Lys 
        35                  40                  45              


Pro Val Pro Thr Thr Asp Ile Glu Pro Val Thr Val Arg Thr Glu Ala 
    50                  55                  60                  


Thr Val Thr Thr Leu Ala Pro Lys Thr Ser Gln Arg Thr Arg Thr Arg 
65                  70                  75                  80  


Arg Pro Arg Pro Lys His Lys Thr Thr Pro Arg Pro Glu Thr Leu Gln 
                85                  90                  95      


Thr Lys Leu Asp Phe Gly Pro Ile Thr Pro Gly Thr Ser Ser Ala Pro 
            100                 105                 110         


Thr Thr Thr Thr Lys Arg Thr Arg Arg Pro His Pro Lys Pro Lys Thr 
        115                 120                 125             


Thr Pro His Pro Glu Val Pro Gln Thr Lys Leu Ala Pro Lys Val Pro 
    130                 135                 140                 


Gln Arg Thr His Arg Pro His Pro Lys Pro Lys Thr Thr Leu Ser Pro 
145                 150                 155                 160 


Glu Glu Leu Gln Thr Glu Leu Val Pro Ala Thr Ile Phe Glu Pro Val 
                165                 170                 175     


Ser Pro Ile Lys Glu Ala Pro Gly Thr Thr Phe 
            180                 185         


<210>  61
<211>  189
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  61

Xaa Thr Ala Lys Pro Lys Thr Ser Pro Ser Pro Glu Val Ser Tyr Thr 
1               5                   10                  15      


Thr Pro Ala Pro Leu Glu Thr Arg Gly Ile Pro Phe Ile Pro Met Ile 
            20                  25                  30          


Ser Pro Ser Pro Ser Gln Glu Glu Leu Gln Thr Thr Leu Glu Glu Thr 
        35                  40                  45              


Asp Gln Ser Thr Gln Glu Pro Phe Thr Thr Lys Ile Pro Arg Thr Thr 
    50                  55                  60                  


Glu Leu Ala Lys Thr Thr Gln Ala Pro His Arg Phe Tyr Thr Thr Val 
65                  70                  75                  80  


Arg Pro Arg Thr Ser Asp Lys Pro His Ile Arg Pro Val Leu Asn Arg 
                85                  90                  95      


Thr Thr Thr Arg Pro Thr Arg Pro Lys Pro Ser Gly Met Pro Ser Gly 
            100                 105                 110         


Asn Gly Val Gly Thr Gly Val Lys Gln Ala Pro Arg Pro Ser Gly Ala 
        115                 120                 125             


Asp Arg Asn Val Ser Val Asp Ser Thr His Pro Thr Lys Lys Pro Gly 
    130                 135                 140                 


Thr Arg Arg Pro Pro Leu Pro Pro Arg Pro Thr His Pro Arg Arg Lys 
145                 150                 155                 160 


Pro Leu Pro Pro Asn Asn Val Thr Gly Lys Pro Gly Ser Ala Gly Ile 
                165                 170                 175     


Ile Ser Ser Gly Pro Ile Thr Thr Pro Pro Leu Arg Ser 
            180                 185                 


<210>  62
<211>  303
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  62

Xaa Thr Pro Glu Val Glu Lys Ile Ser Ala Arg Pro Thr Thr Val Thr 
1               5                   10                  15      


Pro Glu Thr Val Pro Arg Ser Thr Lys Pro Thr Thr Ser Ser Ala Leu 
            20                  25                  30          


Asp Val Ser Glu Thr Thr Leu Ala Ser Ser Glu Lys Pro Trp Ile Val 
        35                  40                  45              


Pro Thr Ala Lys Ile Ser Glu Asp Ser Lys Val Leu Gln Pro Gln Thr 
    50                  55                  60                  


Ala Thr Tyr Asp Val Phe Ser Ser Pro Thr Thr Ser Asp Glu Pro Glu 
65                  70                  75                  80  


Ile Ser Asp Ser Tyr Thr Ala Thr Ser Asp Arg Ile Leu Asp Ser Ile 
                85                  90                  95      


Pro Pro Lys Thr Ser Arg Thr Leu Glu Gln Pro Arg Ala Thr Leu Ala 
            100                 105                 110         


Pro Ser Glu Thr Pro Phe Val Pro Gln Lys Leu Glu Ile Phe Thr Ser 
        115                 120                 125             


Pro Glu Met Gln Pro Thr Thr Pro Ala Pro Gln Gln Thr Thr Ser Ile 
    130                 135                 140                 


Pro Ser Thr Pro Lys Arg Arg Pro Arg Pro Lys Pro Pro Arg Thr Lys 
145                 150                 155                 160 


Pro Glu Arg Thr Thr Ser Ala Gly Thr Ile Thr Pro Lys Ile Ser Lys 
                165                 170                 175     


Ser Pro Glu Pro Thr Trp Thr Thr Pro Ala Pro Gly Lys Thr Gln Phe 
            180                 185                 190         


Ile Ser Leu Lys Pro Lys Ile Pro Leu Ser Pro Glu Val Thr His Thr 
        195                 200                 205             


Lys Pro Ala Pro Glu Pro Gln Thr Leu Leu Pro Ser Gln Ser Thr Ile 
    210                 215                 220                 


Gly Pro Glu Thr Pro Gly Thr Lys Pro Ser Thr Thr Leu Ala Pro Arg 
225                 230                 235                 240 


Lys Thr Lys Arg Pro Gly Arg Arg Pro Arg Pro Arg Pro Arg Pro Lys 
                245                 250                 255     


Thr Thr Pro Ser Pro Glu Val Pro Lys Ser Lys Pro Ala Leu Glu Pro 
            260                 265                 270         


Ala Thr Ile Gln Pro Glu Pro Leu Val Pro Thr Thr Ala Ser Lys Pro 
        275                 280                 285             


Ser Glu Arg Pro Lys Thr Thr His Arg Pro Asp Ala Pro Gln Ile 
    290                 295                 300             


<210>  63
<211>  151
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  63

Xaa Val Glu Ser Ile Thr Tyr Val Ser Glu Pro Pro Glu Thr Thr Leu 
1               5                   10                  15      


Glu Thr Ser Pro Leu Pro Ser Gln Ser Ile Thr Leu Pro Ser Pro Asp 
            20                  25                  30          


Glu Pro Gln Thr Glu Pro Ala Pro Lys Gln Thr Pro Arg Ala Pro Pro 
        35                  40                  45              


Lys Pro Lys Thr Ser Pro Arg Pro Arg Ile Pro Gln Thr Gln Pro Val 
    50                  55                  60                  


Pro Lys Val Pro Gln Arg Val Thr Ala Lys Pro Lys Thr Ser Pro Ser 
65                  70                  75                  80  


Pro Glu Val Ser Tyr Thr Thr Pro Ala Pro Lys Asp Val Leu Leu Pro 
                85                  90                  95      


His Lys Pro Tyr Pro Glu Val Ser Gln Ser Glu Pro Val Leu Gln Pro 
            100                 105                 110         


Val Thr Phe Arg Phe Glu Pro Pro Lys Thr Thr Ile Ala Pro Leu Glu 
        115                 120                 125             


Thr Arg Gly Ile Pro Phe Ile Pro Met Ile Ser Pro Ser Pro Ser Gln 
    130                 135                 140                 


Glu Glu Leu Gln Thr Thr Leu 
145                 150     


<210>  64
<211>  198
<212>  PRT
<213>  Homo Sapiens

<400>  64

Leu Leu His Lys Asn Leu Gln Glu His Phe Ser Asn Gln Asp Leu Val 
1               5                   10                  15      


Phe Leu Leu Leu Thr Pro Ser Ile Ile Thr Glu Ser Cys Ser Thr His 
            20                  25                  30          


Arg Leu Glu His Ser Leu Tyr Lys Pro Gln Lys Gly Leu Phe His Arg 
        35                  40                  45              


Val Pro Leu Val Val Ala Asn Leu Gly Met Ser Glu Gln Leu Gly Tyr 
    50                  55                  60                  


Lys Thr Val Ser Gly Ser Cys Met Ser Thr Gly Phe Ser Arg Ala Val 
65                  70                  75                  80  


Gln Thr His Ser Ser Lys Phe Phe Glu Glu Asp Gly Ser Leu Lys Glu 
                85                  90                  95      


Val His Lys Ile Asn Glu Met Tyr Ala Ser Leu Gln Glu Glu Leu Lys 
            100                 105                 110         


Leu Tyr Ser Phe Ser Glu Cys His Leu His Pro Gly Ser Arg Leu Lys 
        115                 120                 125             


Glu Gln Pro Leu Phe Gly Thr Cys Pro His Gly Ile Arg Gln Arg Ala 
    130                 135                 140                 


Arg Lys Leu Val Asp Tyr Arg Arg Glu Pro Pro Gln Leu Ala His Glu 
145                 150                 155                 160 


Leu Ile Phe Gln Phe Ile Ser Val Tyr Phe Gln Arg Thr Asn Trp His 
                165                 170                 175     


Asp Lys Ser Cys Ile Asn Glu Lys Leu His Val Lys Lys His Phe Thr 
            180                 185                 190         


Thr Tyr Lys Ala Tyr Leu 
        195             


<210>  65
<211>  360
<212>  PRT
<213>  Homo Sapiens

<400>  65

Met Asp Asp Val Glu Val Val Tyr Thr Ile Asp Ile Gln Lys Tyr Ile 
1               5                   10                  15      


Pro Cys Tyr Gln Leu Phe Ser Phe Tyr Asn Ser Ser Gly Glu Val Asn 
            20                  25                  30          


Glu Gln Ala Leu Lys Lys Ile Leu Ser Asn Val Lys Lys Asn Val Val 
        35                  40                  45              


Gly Trp Tyr Lys Phe Arg Arg His Ser Asp Gln Ile Met Thr Phe Arg 
    50                  55                  60                  


Glu Arg Leu Leu His Lys Asn Leu Gln Glu His Phe Ser Asn Gln Asp 
65                  70                  75                  80  


Leu Val Phe Leu Leu Leu Thr Pro Ser Ile Ile Thr Glu Ser Cys Ser 
                85                  90                  95      


Thr His Arg Leu Glu His Ser Leu Tyr Lys Pro Gln Lys Gly Leu Phe 
            100                 105                 110         


His Arg Val Pro Leu Val Val Ala Asn Leu Gly Met Ser Glu Gln Leu 
        115                 120                 125             


Gly Tyr Lys Thr Val Ser Gly Ser Cys Met Ser Thr Gly Phe Ser Arg 
    130                 135                 140                 


Ala Val Gln Thr His Ser Ser Lys Phe Phe Glu Glu Asp Gly Ser Leu 
145                 150                 155                 160 


Lys Glu Val His Lys Ile Asn Glu Met Tyr Ala Ser Leu Gln Glu Glu 
                165                 170                 175     


Leu Lys Ser Ile Cys Lys Lys Val Glu Asp Ser Glu Gln Ala Val Asp 
            180                 185                 190         


Lys Leu Val Lys Asp Val Asn Arg Leu Lys Arg Glu Ile Glu Lys Arg 
        195                 200                 205             


Arg Gly Ala Gln Ile Gln Ala Ala Arg Glu Lys Asn Ile Gln Lys Asp 
    210                 215                 220                 


Pro Gln Glu Asn Ile Phe Leu Cys Gln Ala Leu Arg Thr Phe Phe Pro 
225                 230                 235                 240 


Asn Ser Glu Phe Leu His Ser Cys Val Met Ser Leu Lys Asn Arg His 
                245                 250                 255     


Val Ser Lys Ser Ser Cys Asn Tyr Asn His His Leu Asp Val Val Asp 
            260                 265                 270         


Asn Leu Thr Leu Met Val Glu His Thr Asp Ile Pro Glu Ala Ser Pro 
        275                 280                 285             


Ala Ser Thr Pro Gln Ile Ile Lys His Lys Ala Leu Asp Leu Asp Asp 
    290                 295                 300                 


Arg Trp Gln Phe Lys Arg Ser Arg Leu Leu Asp Thr Gln Asp Lys Arg 
305                 310                 315                 320 


Ser Lys Ala Asp Thr Gly Ser Ser Asn Gln Asp Lys Ala Ser Lys Met 
                325                 330                 335     


Ser Ser Pro Glu Thr Asp Glu Glu Ile Glu Lys Met Lys Gly Phe Gly 
            340                 345                 350         


Glu Tyr Ser Arg Ser Pro Thr Phe 
        355                 360 


<210>  66
<211>  74
<212>  PRT
<213>  Homo Sapiens

<400>  66

Met Glu Gly Glu Ser Thr Ser Ala Val Leu Ser Gly Phe Val Leu Gly 
1               5                   10                  15      


Ala Leu Ala Phe Gln His Leu Asn Thr Asp Ser Asp Thr Glu Gly Phe 
            20                  25                  30          


Leu Leu Gly Glu Val Lys Gly Glu Ala Lys Asn Ser Ile Thr Asp Ser 
        35                  40                  45              


Gln Met Asp Asp Val Glu Val Val Tyr Thr Ile Asp Ile Gln Lys Tyr 
    50                  55                  60                  


Ile Pro Cys Tyr Gln Leu Phe Arg Met Trp 
65                  70                  


<210>  67
<211>  409
<212>  PRT
<213>  Homo Sapiens

<400>  67

Met Glu Gly Glu Ser Thr Ser Ala Val Leu Ser Gly Phe Val Leu Gly 
1               5                   10                  15      


Ala Leu Ala Phe Gln His Leu Asn Thr Asp Ser Asp Thr Glu Gly Phe 
            20                  25                  30          


Leu Leu Gly Glu Val Lys Gly Glu Ala Lys Asn Ser Ile Thr Asp Ser 
        35                  40                  45              


Gln Met Asp Asp Val Glu Val Val Tyr Thr Ile Asp Ile Gln Lys Tyr 
    50                  55                  60                  


Ile Pro Cys Tyr Gln Leu Phe Ser Phe Tyr Asn Ser Ser Gly Glu Val 
65                  70                  75                  80  


Asn Glu Gln Ala Leu Lys Lys Ile Leu Ser Asn Val Lys Lys Asn Val 
                85                  90                  95      


Val Gly Trp Tyr Lys Phe Arg Arg His Ser Asp Gln Ile Met Thr Phe 
            100                 105                 110         


Arg Glu Arg Leu Leu His Lys Asn Leu Gln Glu His Phe Ser Asn Gln 
        115                 120                 125             


Asp Leu Val Phe Leu Leu Leu Thr Pro Ser Ile Ile Thr Glu Ser Cys 
    130                 135                 140                 


Ser Thr His Arg Leu Glu His Ser Leu Tyr Lys Pro Gln Lys Gly Leu 
145                 150                 155                 160 


Phe His Arg Val Pro Leu Val Val Ala Asn Leu Gly Met Ser Glu Gln 
                165                 170                 175     


Leu Gly Tyr Lys Thr Val Ser Gly Ser Cys Met Ser Thr Gly Phe Ser 
            180                 185                 190         


Arg Ala Val Gln Thr His Ser Ser Lys Phe Phe Glu Glu Asp Gly Ser 
        195                 200                 205             


Leu Lys Glu Val His Lys Ile Asn Glu Met Tyr Ala Ser Leu Gln Glu 
    210                 215                 220                 


Glu Leu Lys Ser Ile Cys Lys Lys Val Glu Asp Ser Glu Gln Ala Val 
225                 230                 235                 240 


Asp Lys Leu Val Lys Asp Val Asn Arg Leu Lys Arg Glu Ile Glu Lys 
                245                 250                 255     


Arg Arg Gly Ala Gln Ile Gln Ala Ala Arg Glu Lys Asn Ile Gln Lys 
            260                 265                 270         


Asp Pro Gln Glu Asn Ile Phe Leu Cys Gln Ala Leu Arg Thr Phe Phe 
        275                 280                 285             


Pro Asn Ser Glu Phe Leu His Ser Cys Val Met Ser Leu Lys Asn Arg 
    290                 295                 300                 


His Val Ser Lys Ser Ser Cys Asn Tyr Asn His His Leu Asp Val Val 
305                 310                 315                 320 


Asp Asn Leu Thr Leu Met Val Glu His Thr Asp Ile Pro Glu Ala Ser 
                325                 330                 335     


Pro Ala Ser Thr Pro Gln Ile Ile Lys His Lys Ala Leu Asp Leu Asp 
            340                 345                 350         


Asp Arg Trp Gln Phe Lys Arg Ser Arg Leu Leu Asp Thr Gln Asp Lys 
        355                 360                 365             


Arg Ser Lys Ala Asp Thr Gly Ser Ser Asn Gln Asp Lys Ala Ser Lys 
    370                 375                 380                 


Met Ser Ser Pro Glu Thr Asp Glu Glu Ile Glu Lys Met Lys Gly Phe 
385                 390                 395                 400 


Gly Glu Tyr Ser Arg Ser Pro Thr Phe 
                405                 


<210>  68
<211>  37
<212>  PRT
<213>  Homo Sapiens

<400>  68

Met Glu Gly Glu Ser Thr Ser Ala Val Leu Ser Gly Phe Val Leu Gly 
1               5                   10                  15      


Ala Leu Ala Phe Gln His Leu Asn Thr Asp Ser Asp Thr Val Gly Arg 
            20                  25                  30          


Gly Gly Ser Arg Leu 
        35          


<210>  69
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  69

Met Glu Gly Glu Ser Thr Ser Ala Val Leu Ser Gly Phe Val Leu Gly 
1               5                   10                  15      


Ala Leu Ala Phe Gln His Leu Asn Thr Asp Ser Asp Thr Val Ser Arg 
            20                  25                  30          


Gly Thr Gly Arg Gly Pro Ala Ser Pro Gly Lys Ser Pro Ala Arg Gly 
        35                  40                  45              


Leu Pro Pro Arg Cys Cys Ser Gly Pro Arg Pro Leu Pro Arg Arg Arg 
    50                  55                  60                  


Arg Ala Ser Ser Leu Arg Ser Arg Leu Cys Leu Leu Ser Pro Ser Ala 
65                  70                  75                  80  


Val Pro Glu Glu Gly Phe Leu Leu Gly Glu Val Lys Gly Glu Ala Lys 
                85                  90                  95      


Asn Ser Ile Thr Asp Ser Gln Met Asp Asp Val Glu Val Val Tyr Thr 
            100                 105                 110         


Ile Asp Ile Gln Lys Tyr Ile Pro Cys Tyr Gln Leu Phe Ser Phe Tyr 
        115                 120                 125             


Asn Ser Ser Gly Glu Val Asn Glu Gln Ala Leu Lys Lys Ile Leu Ser 
    130                 135                 140                 


Asn Val Lys Lys Asn Val Val Gly Trp Tyr Lys Phe Arg Arg His Ser 
145                 150                 155                 160 


Asp Gln Ile Met Thr Phe Arg Glu Arg Leu Leu His Lys Asn Leu Gln 
                165                 170                 175     


Glu His Phe Ser Asn Gln Asp Leu Val Phe Leu Leu Leu 
            180                 185                 


<210>  70
<211>  220
<212>  PRT
<213>  Homo Sapiens

<400>  70

Met Lys Thr Ser Ser Pro Lys Glu Asn Cys Leu Phe Leu Cys Phe Thr 
1               5                   10                  15      


Ser Met Lys Asn Gly Gln Glu Gly Phe Leu Leu Gly Glu Val Lys Gly 
            20                  25                  30          


Glu Ala Lys Asn Ser Ile Thr Asp Ser Gln Met Asp Asp Val Glu Val 
        35                  40                  45              


Val Tyr Thr Ile Asp Ile Gln Lys Tyr Ile Pro Cys Tyr Gln Leu Phe 
    50                  55                  60                  


Ser Phe Tyr Asn Ser Ser Gly Glu Val Asn Glu Gln Ala Leu Lys Lys 
65                  70                  75                  80  


Ile Leu Ser Asn Val Lys Lys Asn Val Val Gly Trp Tyr Lys Phe Arg 
                85                  90                  95      


Arg His Ser Asp Gln Ile Met Thr Phe Arg Glu Arg Leu Leu His Lys 
            100                 105                 110         


Asn Leu Gln Glu His Phe Ser Asn Gln Asp Leu Val Phe Leu Leu Leu 
        115                 120                 125             


Thr Pro Ser Ile Ile Thr Glu Ser Cys Ser Thr His Arg Leu Glu His 
    130                 135                 140                 


Ser Leu Tyr Lys Pro Gln Lys Gly Leu Phe His Arg Val Pro Leu Val 
145                 150                 155                 160 


Val Ala Asn Leu Gly Met Ser Glu Gln Leu Gly Tyr Lys Thr Val Ser 
                165                 170                 175     


Gly Ser Cys Met Ser Thr Gly Phe Ser Arg Ala Val Gln Thr His Ser 
            180                 185                 190         


Ser Lys Phe Phe Glu Glu Asp Gly Ser Leu Lys Glu Val His Lys Ile 
        195                 200                 205             


Asn Glu Met Tyr Ala Ser Leu Gln Glu Glu Leu Lys 
    210                 215                 220 


<210>  71
<211>  82
<212>  PRT
<213>  Homo Sapiens

<400>  71

Met Met Leu Lys Leu Phe Ile Gln Leu Met Glu Ser His Ser Val Ala 
1               5                   10                  15      


Gln Thr Gly Val Lys Trp His Asp Leu Gly Ser Leu Gln Pro Leu Pro 
            20                  25                  30          


Leu Glu Val Lys Arg Phe Ser Cys Leu Gly Leu Arg Ser Ser Trp Asp 
        35                  40                  45              


Tyr Arg His Thr Gln Pro Cys Pro Ala Asn Phe Phe Cys Ile Phe Ser 
    50                  55                  60                  


Arg Asp Gly Val Ser Pro Cys Trp Pro Gly Trp Ser Arg Thr Pro Asp 
65                  70                  75                  80  


Leu Lys 
        


<210>  72
<211>  536
<212>  PRT
<213>  Homo Sapiens

<400>  72

Met Gly Ala Trp Ala Phe Pro Ala Ala Leu Phe Leu Leu Cys Leu Thr 
1               5                   10                  15      


Ser Glu Ser Leu Gln Gly Gly Leu Pro Leu Leu Pro Pro Gly Leu Gly 
            20                  25                  30          


Lys Val Tyr Gly Pro His Ser Gly Leu Gly Ala Gly Tyr Asp Gly Gly 
        35                  40                  45              


Val Lys Pro Gln Lys Pro Gly Phe Val Val Arg His Gly Leu Gly Thr 
    50                  55                  60                  


Gln Pro Asp Thr Glu Gly Gly Met Lys Pro Gln Asn Leu Gly Phe Arg 
65                  70                  75                  80  


Thr Phe Ala Gly Ala Ala Ala Gln Pro Gly Tyr Gly Asn Gly Leu Gly 
                85                  90                  95      


Ala Ala Ala Phe Pro Val Ala Gly Ala Gln Ser Gly Pro Ala Ala Gln 
            100                 105                 110         


Asn Gly Phe Gly Pro Gly Phe Gly Gly Gly Gly Lys Pro Gln Lys Pro 
        115                 120                 125             


Gly Pro Thr Thr Gln Asn Gly Tyr Arg Pro Gly Tyr Val Gly Ala Val 
    130                 135                 140                 


Lys Pro Gln Lys Pro Gly Phe Gln Tyr Arg Ile Gly Leu Gly Ala Gln 
145                 150                 155                 160 


Pro Gly Phe Arg Gly Asp Met Lys Ala Gln Glu Pro Gly Leu Gly Asn 
                165                 170                 175     


Gly Asn Gly Leu Ser Ala Gln Pro Val Leu Thr Ala Gln Asn Arg Phe 
            180                 185                 190         


Gly Phe Gly Ala Gly Leu Gly Gly Asn Val Lys Pro Leu Lys Pro Gly 
        195                 200                 205             


Tyr Gly Lys Arg Leu Arg Ala Gly Ala Phe Pro Gly Ala Gly Thr Gln 
    210                 215                 220                 


Pro Glu Tyr Gly His Gly Asn Gly Pro Gly Val Gln Pro Gly Leu Gly 
225                 230                 235                 240 


Ala Gly Met Lys Pro Gln Met Pro Gly Leu Gly Ala Pro Asn Gly Tyr 
                245                 250                 255     


Gly Pro Gly Arg Gly Arg Ala Gly Val Pro Gly Gly Pro Glu Arg Arg 
            260                 265                 270         


Pro Trp Val Pro His Leu Leu Pro Phe Ser Ser Pro Gly Tyr Leu Gly 
        275                 280                 285             


Val Met Lys Ala Gln Lys Pro Gly Pro Leu Ala Gln Asn Gly Tyr Arg 
    290                 295                 300                 


Ala Gly Ala Gly Glu Gly Met Lys Pro Gln Lys Pro Gly Leu Arg Gly 
305                 310                 315                 320 


Thr Leu Lys Pro Gln Lys Ser Gly His Gly His Glu Asn Gly Pro Trp 
                325                 330                 335     


Pro Gly Pro Cys Asn Ala Arg Val Ala Pro Met Leu Leu Pro Arg Leu 
            340                 345                 350         


Pro Thr Pro Gly Val Pro Ser Asp Lys Glu Gly Gly Trp Gly Leu Lys 
        355                 360                 365             


Ser Gln Pro Pro Ser Ala Val Gln Asn Gly Lys Leu Pro Ala Pro Met 
    370                 375                 380                 


Pro Ala Ile Gln Trp Gly Leu Lys Pro Gln Lys Ala Gly His Gln Pro 
385                 390                 395                 400 


Pro Asn Gly Tyr Gly Pro Gly Ala Glu Pro Gly Phe Asn Gly Gly Leu 
                405                 410                 415     


Glu Pro Gln Lys Ile Gly Leu Gly Tyr Gly Asn Gly Val Leu Gly Ala 
            420                 425                 430         


Arg Val Phe Pro Glu Ala His Pro Gln Pro Gly Phe His Gly Ala Asn 
        435                 440                 445             


Gly Phe Arg Asn Arg Asp Gly Val Glu Ala Leu Val Tyr Pro Lys Ala 
    450                 455                 460                 


Ala Ala Leu Ala Pro Glu Gly Asn Gly Gln Ala Gly Val Leu Trp Asn 
465                 470                 475                 480 


Ser Arg Trp Pro Thr Leu Gln Ala Trp Gly Ala Gly Leu Lys Pro Gly 
                485                 490                 495     


Tyr Gln Ala Gly Asp Glu Tyr Ala Glu Ala Arg Ser Gln Pro Gly Gly 
            500                 505                 510         


Pro Asp Val Lys Arg Gly Ser Asn Gly Gln Leu Gly Asn Gly Tyr Gly 
        515                 520                 525             


Gly Arg Cys Pro Leu Gly Lys Cys 
    530                 535     


<210>  73
<211>  195
<212>  PRT
<213>  Homo Sapiens

<400>  73

Met Pro Asn Phe Leu Gly Leu His Arg Ala Arg Ser Phe Thr Val Leu 
1               5                   10                  15      


Cys Phe Trp Ser Thr Ala Asp Val Leu Asn Ala Ser Gly Pro Arg Arg 
            20                  25                  30          


Gln Trp His Pro Leu Ala Ser Cys Ser Ser Trp Ser Arg Pro Gln Ser 
        35                  40                  45              


Gln Gly Ser Thr Pro Gly Val Leu Cys Lys Thr Gly Met Gly Arg Glu 
    50                  55                  60                  


Pro Ile Pro Glu Thr Gln Cys His Phe Ala Asn Ser Met Cys Ser Leu 
65                  70                  75                  80  


His Val Ser Val Pro Tyr Phe Gly Asn Ser Pro Asn Ile Ser Asn Phe 
                85                  90                  95      


Phe Arg Trp Ser Leu Ala Leu Ser Pro Arg Gln Trp Cys Asp Leu Gly 
            100                 105                 110         


Ser Leu Gln Pro Pro Ser Pro Arg Phe Lys Gly Phe Ser Cys Leu Ser 
        115                 120                 125             


Leu Pro Ser Ser Trp Asp Tyr Arg Arg Ala Pro Ser Pro Ala Asn Phe 
    130                 135                 140                 


Cys Ile Leu Val Glu Met Gly Phe His His Val Gly Gln Ala Asp Leu 
145                 150                 155                 160 


Glu Leu Leu Thr Ser Ala Asp Leu Pro Thr Ser Ala Ser Gln Ser Ala 
                165                 170                 175     


Gly Ile Thr Gly Val Ser His His Ala Trp Pro Gln Thr Leu Ser Leu 
            180                 185                 190         


Leu Leu Tyr 
        195 


<210>  74
<211>  130
<212>  PRT
<213>  Homo Sapiens

<400>  74

Met Gly Gly Thr Trp Ala Ser Lys Glu Pro Leu Arg Pro Arg Cys Arg 
1               5                   10                  15      


Pro Ile Asn Ala Thr Leu Ala Val Glu Lys Glu Gly Cys Pro Val Cys 
            20                  25                  30          


Ile Thr Val Asn Thr Thr Ile Cys Ala Gly Tyr Cys Pro Thr Met Thr 
        35                  40                  45              


Arg Val Leu Gln Gly Val Leu Pro Ala Leu Pro Gln Val Val Cys Asn 
    50                  55                  60                  


Tyr Arg Asp Val Arg Phe Glu Ser Ile Arg Leu Pro Gly Cys Pro Arg 
65                  70                  75                  80  


Gly Val Asn Pro Val Val Ser Tyr Ala Val Ala Leu Ser Cys Gln Cys 
                85                  90                  95      


Ala Leu Cys Arg Arg Ser Thr Thr Asp Cys Gly Gly Pro Lys Asp His 
            100                 105                 110         


Pro Leu Thr Cys Asp Asp Pro Arg Phe Gln Asp Ser Ser Ser Ser Lys 
        115                 120                 125             


Ala Pro 
    130 


<210>  75
<211>  77
<212>  PRT
<213>  Homo Sapiens

<400>  75

Met Ser Lys Gly Leu Leu Leu Leu Leu Leu Leu Ser Met Gly Gly Thr 
1               5                   10                  15      


Trp Ala Ser Lys Glu Pro Leu Arg Pro Arg Cys Arg Pro Ile Asn Ala 
            20                  25                  30          


Thr Leu Ala Val Glu Lys Glu Gly Cys Pro Val Cys Ile Thr Val Asn 
        35                  40                  45              


Thr Thr Ile Cys Ala Gly Tyr Cys Pro Thr Met Thr Arg Val Leu Gln 
    50                  55                  60                  


Gly Val Leu Pro Ala Leu Pro Gln Val Val Cys Asn Tyr 
65                  70                  75          


<210>  76
<211>  165
<212>  PRT
<213>  Homo Sapiens

<400>  76

Met Asp Ala Glu Gly Leu Ala Leu Leu Leu Pro Pro Val Thr Leu Ala 
1               5                   10                  15      


Ala Leu Val Asp Ser Trp Leu Arg Glu Asp Cys Pro Gly Leu Asn Tyr 
            20                  25                  30          


Ala Ala Leu Val Ser Gly Ala Gly Pro Ser Gln Ala Ala Leu Trp Ala 
        35                  40                  45              


Lys Ser Pro Gly Val Leu Ala Gly Gln Pro Phe Phe Asp Ala Ile Phe 
    50                  55                  60                  


Thr Gln Leu Asn Cys Gln Val Ser Trp Phe Leu Pro Glu Gly Ser Lys 
65                  70                  75                  80  


Leu Val Pro Val Ala Arg Val Ala Glu Val Arg Gly Pro Ala His Cys 
                85                  90                  95      


Leu Leu Leu Gly Glu Arg Val Ala Leu Asn Thr Leu Ala Arg Cys Ser 
            100                 105                 110         


Gly Ile Ala Ser Ala Ala Ala Ala Ala Val Glu Ala Ala Arg Gly Ala 
        115                 120                 125             


Gly Trp Thr Gly His Val Ala Gly Thr Arg Lys Thr Thr Pro Gly Phe 
    130                 135                 140                 


Arg Leu Val Glu Lys Tyr Gly Leu Leu Val Gly Gly Ala Ala Ser His 
145                 150                 155                 160 


Arg Tyr Asp Leu Gly 
                165 


<210>  77
<211>  210
<212>  PRT
<213>  Homo Sapiens

<400>  77

Met Ser Arg Ala Gly Ser His Pro Lys Pro Ala Ile Pro Gly Arg Gly 
1               5                   10                  15      


Gly Glu Lys Leu Ala Leu Leu Leu Ala Met Leu Gly Gly Arg Cys Cys 
            20                  25                  30          


Pro Ala Gly Gly Pro Glu Ser His Thr Pro Arg Lys Pro Trp Pro Pro 
        35                  40                  45              


Ile Arg Arg Glu Arg Pro Gly Leu Arg Ser Pro Lys Pro Arg Glu Glu 
    50                  55                  60                  


Ala Gly Pro Arg Ala Asp Ser Lys Ala Ala Ser Pro Ala Leu Phe Met 
65                  70                  75                  80  


Gly Pro Gly Ser Arg Gly Arg Arg Arg Pro Pro Ser Trp Ala Arg Arg 
                85                  90                  95      


Arg Ala Arg Gly Gly Arg Gly Ser Cys Pro Glu Pro His Val Arg Ala 
            100                 105                 110         


Gly Pro Arg Phe Phe Ile Ala Leu Ala Ala Pro Ala Ala Arg Gly Leu 
        115                 120                 125             


Arg Val Ser Ser Gln Gly Pro Gly Leu Trp Arg Gly Pro Ala Ala Arg 
    130                 135                 140                 


Lys Glu Gly Val Ala Arg Val Gly Val Ala Ala Gly Leu Arg Leu Arg 
145                 150                 155                 160 


Pro Arg Gly Arg Gly Arg Lys Thr Thr Pro Ala Leu Ser Gly His Pro 
                165                 170                 175     


Ala Arg Phe Pro Leu Gln Pro Gly Asp Ser Arg Glu Arg Ser Arg Asn 
            180                 185                 190         


His Arg Ala Leu Glu Leu Thr Trp Gln Pro Arg Gly Ala Lys Ala Gly 
        195                 200                 205             


Gly Ala 
    210 


<210>  78
<211>  83
<212>  PRT
<213>  Homo Sapiens

<400>  78

Met Lys Gly Trp Gly Trp Leu Ala Leu Leu Leu Gly Ala Leu Leu Gly 
1               5                   10                  15      


Thr Ala Trp Ala Arg Arg Ser Gln Asp Leu His Cys Gly Ala Cys Arg 
            20                  25                  30          


Ala Leu Val Asp Glu Leu Glu Trp Glu Ile Ala Gln Val Asp Pro Lys 
        35                  40                  45              


Lys Thr Ile Gln Met Gly Ser Phe Arg Ile Asn Pro Asp Gly Ser Gln 
    50                  55                  60                  


Ser Val Val Glu Ile Pro Glu Ile Ala Arg His Gly Phe Thr Tyr Cys 
65                  70                  75                  80  


Gly Arg Pro 
            


<210>  79
<211>  105
<212>  PRT
<213>  Homo Sapiens

<400>  79

Met Lys Gly Trp Gly Trp Leu Ala Leu Leu Leu Gly Ala Leu Leu Gly 
1               5                   10                  15      


Thr Ala Trp Ala Arg Arg Ser Gln Asp Leu His Cys Gly Ala Cys Arg 
            20                  25                  30          


Ala Leu Val Asp Glu Leu Glu Trp Glu Ile Ala Gln Val Asp Pro Lys 
        35                  40                  45              


Lys Thr Ile Gln Met Gly Ser Phe Arg Ile Asn Pro Asp Gly Ser Gln 
    50                  55                  60                  


Ser Val Val Glu Asn Ala Ser Cys Leu Val Leu Ala Ala Arg His Ala 
65                  70                  75                  80  


Ser Ala Ser Ser Thr Asn Leu Lys Asp Ile Leu Ala Asp Leu Ile Pro 
                85                  90                  95      


Lys Glu Gln Ala Arg Ile Lys Thr Phe 
            100                 105 


<210>  80
<211>  263
<212>  PRT
<213>  Homo Sapiens

<400>  80

Met Lys Gly Trp Gly Trp Leu Ala Leu Leu Leu Gly Ala Leu Leu Gly 
1               5                   10                  15      


Thr Ala Trp Ala Arg Arg Ser Gln Asp Leu His Cys Gly Ala Cys Arg 
            20                  25                  30          


Ala Leu Val Asp Glu Leu Glu Trp Glu Ile Ala Gln Val Asp Pro Lys 
        35                  40                  45              


Lys Thr Ile Gln Met Gly Ser Phe Arg Ile Asn Pro Asp Gly Ser Gln 
    50                  55                  60                  


Ser Val Val Glu Val Pro Tyr Ala Arg Ser Glu Ala His Leu Thr Glu 
65                  70                  75                  80  


Leu Leu Glu Glu Ile Cys Asp Arg Met Lys Glu Tyr Gly Glu Gln Ile 
                85                  90                  95      


Asp Pro Ser Thr His Arg Lys Asn Tyr Val Arg Val Val Gly Arg Asn 
            100                 105                 110         


Gly Glu Ser Ser Glu Leu Asp Leu Gln Gly Ile Arg Ile Asp Ser Asp 
        115                 120                 125             


Ile Ser Gly Thr Leu Lys Phe Ala Cys Glu Ser Ile Val Glu Glu Tyr 
    130                 135                 140                 


Glu Asp Glu Leu Ile Glu Phe Phe Ser Arg Glu Ala Asp Asn Val Lys 
145                 150                 155                 160 


Asp Lys Leu Cys Ser Lys Arg Thr Asp Gly Gly Thr Ser Lys Asn Arg 
                165                 170                 175     


Asp Arg Lys Gly Lys Met Asp Val Thr Asn Ser Ala Glu Lys Ser Arg 
            180                 185                 190         


Arg Ser Pro Ala Met Ala Leu Leu Thr Ala Ala Ala Arg Leu Leu Gly 
        195                 200                 205             


Thr Lys Asn Ala Ser Cys Leu Val Leu Ala Ala Arg His Ala Ser Ala 
    210                 215                 220                 


Ser Ser Thr Asn Leu Lys Asp Ile Leu Ala Asp Leu Ile Pro Lys Glu 
225                 230                 235                 240 


Gln Ala Arg Ile Lys Thr Phe Arg Gln Gln His Gly Lys Thr Val Val 
                245                 250                 255     


Gly Gln Ile Thr Val Asp Met 
            260             


<210>  81
<211>  171
<212>  PRT
<213>  Homo Sapiens

<400>  81

Met Pro Glu Thr Ser His Ile Val Ala Leu Thr Ser Lys Ser Glu Gln 
1               5                   10                  15      


Glu Leu Tyr Ile Pro Ser Val Val Ser Asn Ser Pro Ser Thr Val Gln 
            20                  25                  30          


Ser Ile Glu Asn Thr Ser Lys Ser His Gly Glu Ile Phe Lys Lys Asp 
        35                  40                  45              


Val Cys Ala Glu Asn Asn Asn Asn Met Ala Met Leu Ile Cys Leu Ile 
    50                  55                  60                  


Ile Ile Ala Val Leu Phe Leu Ile Cys Thr Phe Leu Phe Leu Ser Thr 
65                  70                  75                  80  


Val Val Leu Ala Asn Lys Val Ser Ser Leu Arg Arg Ser Lys Gln Val 
                85                  90                  95      


Gly Lys Arg Gln Pro Arg Ser Asn Gly Asp Phe Leu Ala Ser Gly Leu 
            100                 105                 110         


Trp Pro Ala Glu Ser Asp Thr Trp Lys Arg Thr Lys Gln Leu Thr Gly 
        115                 120                 125             


Pro Asn Leu Val Met Gln Ser Thr Gly Val Leu Thr Ala Thr Arg Glu 
    130                 135                 140                 


Arg Lys Asp Glu Glu Gly Thr Glu Lys Leu Thr Asn Lys Gln Ile Ala 
145                 150                 155                 160 


Lys Ser Pro Lys Cys Pro Val Arg Thr Arg Ile 
                165                 170     


<210>  82
<211>  123
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  82

Xaa Cys Ala Glu Asn Asn Asn Asn Met Ala Met Leu Ile Cys Leu Ile 
1               5                   10                  15      


Ile Ile Ala Val Leu Phe Leu Ile Cys Thr Phe Leu Phe Leu Ser Thr 
            20                  25                  30          


Val Val Leu Ala Asn Lys Val Ser Ser Leu Arg Arg Ser Lys Gln Val 
        35                  40                  45              


Gly Lys Arg Gln Pro Arg Ser Asn Gly Asp Phe Leu Ala Ser Gly Leu 
    50                  55                  60                  


Trp Pro Ala Glu Ser Asp Thr Trp Lys Arg Thr Lys Gln Leu Thr Gly 
65                  70                  75                  80  


Pro Asn Leu Val Met Gln Ser Thr Gly Val Leu Thr Ala Thr Arg Glu 
                85                  90                  95      


Arg Lys Asp Glu Glu Gly Thr Glu Lys Leu Thr Asn Lys Gln Ile Ala 
            100                 105                 110         


Lys Ser Pro Lys Cys Pro Val Arg Thr Arg Ile 
        115                 120             


<210>  83
<211>  117
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  83

Xaa Cys Ala Glu Asn Asn Asn Asn Met Ala Met Leu Ile Cys Leu Ile 
1               5                   10                  15      


Ile Ile Ala Val Leu Phe Leu Ile Cys Thr Phe Leu Phe Leu Ser Thr 
            20                  25                  30          


Val Val Leu Ala Asn Lys Val Ser Ser Leu Arg Arg Ser Lys Gln Val 
        35                  40                  45              


Gly Lys Arg Gln Pro Arg Ser Asn Gly Asp Phe Leu Ala Ser Gly Leu 
    50                  55                  60                  


Trp Pro Ala Glu Ser Asp Thr Trp Lys Arg Thr Lys Gln Leu Thr Gly 
65                  70                  75                  80  


Pro Asn Leu Val Met Gln Ser Thr Gly Val Leu Thr Ala Thr Arg Glu 
                85                  90                  95      


Arg Lys Asp Glu Glu Gly Thr Glu Lys Leu Thr Asn Lys Gln Ile Asp 
            100                 105                 110         


Asn Glu Glu Ile Phe 
        115         


<210>  84
<211>  153
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  84

Xaa Cys Ala Glu Asn Asn Asn Asn Met Ala Met Leu Ile Cys Leu Ile 
1               5                   10                  15      


Ile Ile Ala Val Leu Phe Leu Ile Cys Thr Phe Leu Phe Leu Ser Thr 
            20                  25                  30          


Val Val Leu Ala Asn Lys Val Ser Ser Leu Arg Arg Ser Lys Gln Val 
        35                  40                  45              


Gly Lys Arg Gln Pro Arg Ser Asn Gly Asp Phe Leu Ala Ser Gly Leu 
    50                  55                  60                  


Trp Pro Ala Glu Ser Asp Thr Trp Lys Arg Thr Lys Gln Leu Thr Gly 
65                  70                  75                  80  


Pro Asn Leu Val Met Gln Ser Thr Gly Val Leu Thr Ala Thr Arg Glu 
                85                  90                  95      


Arg Lys Asp Glu Glu Gly Thr Glu Lys Leu Thr Asn Lys Gln Ile Glu 
            100                 105                 110         


Glu Glu Thr Val Thr Gln Lys Cys Arg Val Leu Pro Lys Val Ile Gln 
        115                 120                 125             


Val Asn Arg Thr His His Ser Leu Leu Met Arg Arg Asn Leu Thr Lys 
    130                 135                 140                 


Leu Phe Gln Phe Ala Arg Gly Thr Phe 
145                 150             


<210>  85
<211>  104
<212>  PRT
<213>  Homo Sapiens

<400>  85

Met Gly Ser Thr Trp Gly Ser Pro Gly Trp Val Arg Leu Ala Leu Cys 
1               5                   10                  15      


Leu Thr Gly Leu Val Leu Ser Leu Tyr Ala Leu His Val Lys Ala Ala 
            20                  25                  30          


Arg Ala Arg Asp Arg Asp Tyr Arg Ala Leu Cys Asp Val Gly Thr Ala 
        35                  40                  45              


Ile Ser Cys Ser Arg Val Phe Ser Ser Arg Ala Ala Ala Thr Glu Leu 
    50                  55                  60                  


Asn Ser Trp Ser Val Val Leu Gly Ser Leu Gln Arg Glu Gly Leu Ser 
65                  70                  75                  80  


Pro Gly Ala Glu Glu Val Gly Val Ala Ala Leu Gln Leu Pro Arg Ala 
                85                  90                  95      


Tyr Asn His Tyr Ser Gln Gly Ser 
            100                 


<210>  86
<211>  166
<212>  PRT
<213>  Homo Sapiens

<400>  86

Met Gly Ser Thr Trp Gly Ser Pro Gly Trp Val Arg Leu Ala Leu Cys 
1               5                   10                  15      


Leu Thr Gly Leu Val Leu Ser Leu Tyr Ala Leu His Val Lys Ala Ala 
            20                  25                  30          


Arg Ala Arg Asp Arg Asp Tyr Arg Ala Leu Cys Asp Val Gly Thr Ala 
        35                  40                  45              


Ile Ser Cys Ser Arg Val Phe Ser Ser Arg Trp Gly Arg Gly Phe Gly 
    50                  55                  60                  


Leu Val Glu His Val Leu Gly Gln Asp Ser Ile Leu Asn Gln Ser Asn 
65                  70                  75                  80  


Ser Ile Phe Gly Cys Ile Phe Tyr Thr Leu Gln Leu Leu Leu Gly Leu 
                85                  90                  95      


Gln Ala Ala Gln Arg Ala Cys Gly Gln Arg Gly Pro Gly Pro Pro Lys 
            100                 105                 110         


Pro Gln Glu Gly Asn Thr Val Pro Gly Glu Trp Pro Trp Gln Ala Ser 
        115                 120                 125             


Val Arg Arg Gln Gly Ala His Ile Cys Ser Gly Ser Leu Val Ala Asp 
    130                 135                 140                 


Thr Trp Val Leu Thr Ala Ala His Cys Phe Glu Lys Ala Ala Ala Thr 
145                 150                 155                 160 


Glu Leu Asn Ser Trp Ser 
                165     


<210>  87
<211>  121
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  87

Xaa Asp Val Gly Thr Ala Ile Ser Cys Ser Arg Val Phe Ser Ser Arg 
1               5                   10                  15      


Trp Gly Arg Gly Phe Gly Leu Val Glu His Val Leu Gly Gln Asp Ser 
            20                  25                  30          


Ile Leu Asn Gln Ser Asn Ser Ile Phe Gly Cys Ile Phe Tyr Thr Leu 
        35                  40                  45              


Gln Leu Leu Leu Gly Cys Leu Arg Thr Arg Trp Ala Ser Val Leu Met 
    50                  55                  60                  


Leu Leu Ser Ser Leu Val Ser Leu Ala Gly Ser Val Tyr Leu Ala Trp 
65                  70                  75                  80  


Ile Leu Phe Phe Val Leu Tyr Asp Phe Cys Ile Val Cys Ile Thr Thr 
                85                  90                  95      


Tyr Ala Ile Asn Val Ser Leu Met Trp Leu Ser Phe Arg Lys Val Gln 
            100                 105                 110         


Glu Pro Gln Gly Lys Ala Lys Arg His 
        115                 120     


<210>  88
<211>  199
<212>  PRT
<213>  Homo Sapiens

<400>  88

Met Ala Leu Leu Leu Arg Phe Val Leu Leu Cys Arg Val Ala Asp Phe 
1               5                   10                  15      


Ile Arg Gly Trp Ser Ile Thr Thr Pro Glu Gln Met Ile Glu Lys Ala 
            20                  25                  30          


Lys Gly Glu Thr Ala Tyr Leu Pro Cys Lys Phe Thr Leu Ser Pro Glu 
        35                  40                  45              


Asp Gln Gly Pro Leu Asp Ile Glu Trp Leu Ile Ser Pro Ala Asp Asn 
    50                  55                  60                  


Gln Lys Val Asp Gln Val Ile Ile Leu Tyr Ser Gly Asp Lys Ile Tyr 
65                  70                  75                  80  


Asp Asp Tyr Tyr Pro Asp Leu Lys Gly Arg Val His Phe Lys Ser Asn 
                85                  90                  95      


Asp Leu Lys Ser Gly Asp Ala Ser Ile Asn Val Thr Asn Phe Gln Leu 
            100                 105                 110         


Ser Asp Ile Gly Thr Asp Gln Cys Lys Val Lys Arg Ala Pro Gly Val 
        115                 120                 125             


Ala Asn Arg Lys Ile Gln Leu Val Val Leu Gly Lys Met Cys Arg Leu 
    130                 135                 140                 


Gln Arg Ala Ala Arg Pro Leu Pro Glu Ala Thr Ala Val Ile Ile His 
145                 150                 155                 160 


Pro Trp Asp Pro Tyr Leu Leu Pro Thr Trp Lys Asp Ile Pro Arg Leu 
                165                 170                 175     


Ser Ile Asn Lys Tyr Gln Val Lys Thr Leu Asn Ala Leu Leu Arg Val 
            180                 185                 190         


Arg Leu Ser His Leu Leu Arg 
        195                 


<210>  89
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  89

Met Glu Phe Gly Leu Asn Trp Val Phe Leu Val Ala Ile Ile Lys Gly 
1               5                   10                  15      


Ala Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Pro Asp Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn His Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Ser Tyr Ile Ser Gly Asp Ser Gly Tyr Thr Asn Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn 
                85                  90                  95      


Ser Pro Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Val 
        115     


<210>  90
<211>  124
<212>  PRT
<213>  Homo Sapiens

<400>  90

Met Leu Cys Pro Arg Ala Ala Phe Leu Val Gly Ser Phe His Gly Val 
1               5                   10                  15      


Phe Pro Gly Pro Pro Ala Ser Ser His Trp Glu Phe Trp Val Pro Ser 
            20                  25                  30          


Thr Pro Val Gly Ala Tyr Phe Cys Pro Pro Gln Pro Gln Leu Thr Pro 
        35                  40                  45              


Pro Asn Thr Pro Lys Leu Val Ser Glu Val Glu Glu Leu Tyr Lys Ser 
    50                  55                  60                  


Ile Thr Ala Leu Arg Glu Lys Leu Leu Gln Ala Glu Gln Ser Leu Arg 
65                  70                  75                  80  


Asn Leu Lys Asp Ile His Met Ser Leu Glu Lys Asp Val Thr Ala Met 
                85                  90                  95      


Thr Asn Ser Val Phe Ile Asp Arg Gln Lys Cys Met Ala His Arg Thr 
            100                 105                 110         


Cys Tyr Pro Thr Ile Leu Gln Leu Ala Gly Tyr Gln 
        115                 120                 


<210>  91
<211>  117
<212>  PRT
<213>  Homo Sapiens

<400>  91

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Ser Ser Gly Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Ser Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn 
65                  70                  75                  80  


Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn 
                85                  90                  95      


Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg 
        115         


<210>  92
<211>  67
<212>  PRT
<213>  Homo Sapiens

<400>  92

Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly 
    50                  55                  60                  


Tyr Ser Trp 
65          


<210>  93
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  93

Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile 
            100                 105                 110         


Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn 
145                 150         


<210>  94
<211>  155
<212>  PRT
<213>  Homo Sapiens

<400>  94

Met Ser Pro Ala Lys Cys Lys Ile Cys Phe Pro Asp Arg Glu Val Lys 
1               5                   10                  15      


Pro Ser Met Ser Gly Leu His Leu Val Lys Arg Gly Arg Glu His Lys 
            20                  25                  30          


Lys Leu Asp Leu His Arg Asp Phe Thr Val Ala Ser Pro Ala Glu Phe 
        35                  40                  45              


Val Thr Arg Phe Gly Gly Asp Arg Val Ile Glu Lys Val Leu Ile Ala 
    50                  55                  60                  


Asn Asn Gly Ile Ala Ala Val Lys Cys Met Arg Ser Ile Arg Arg Trp 
65                  70                  75                  80  


Ala Tyr Glu Met Phe Arg Asn Glu Arg Ala Ile Arg Phe Val Val Met 
                85                  90                  95      


Val Thr Pro Glu Asp Leu Lys Ala Asn Ala Glu Tyr Ile Lys Met Ala 
            100                 105                 110         


Asp His Tyr Val Pro Val Pro Gly Gly Pro Asn Asn Asn Asn Tyr Ala 
        115                 120                 125             


Asn Val Glu Leu Ile Val Asp Ile Ala Lys Arg Ile Pro Val Gln Ala 
    130                 135                 140                 


Val Trp Ala Gly Trp Gly His Ala Ser Glu Asn 
145                 150                 155 


<210>  95
<211>  143
<212>  PRT
<213>  Homo Sapiens

<400>  95

Met Thr Asp Ser Lys Pro Ile Thr Lys Ser Lys Ser Glu Ala Asn Leu 
1               5                   10                  15      


Ile Pro Ser Gln Glu Pro Phe Pro Ala Ser Asp Asn Ser Gly Glu Thr 
            20                  25                  30          


Pro Gln Arg Asn Gly Glu Gly His Thr Leu Pro Lys Thr Pro Ser Gln 
        35                  40                  45              


Ala Glu Pro Ala Ser His Lys Gly Pro Lys Asp Ala Gly Arg Arg Arg 
    50                  55                  60                  


Asn Ser Leu Pro Pro Ser His Gln Lys Pro Pro Arg Asn Pro Leu Ser 
65                  70                  75                  80  


Ser Ser Asp Ala Ala Pro Ser Pro Glu Leu Gln Ala Asn Gly Thr Gly 
                85                  90                  95      


Thr Gln Gly Leu Glu Ala Thr Asp Thr Asn Gly Leu Ser Ser Ser Ala 
            100                 105                 110         


Arg Pro Gln Gly Gln Gln Ala Gly Ser Pro Ser Lys Glu Asp Lys Lys 
        115                 120                 125             


Gln Ala Asn Ile Lys Arg Gln Leu Met Thr Asn Phe Ile Leu Gly 
    130                 135                 140             


<210>  96
<211>  858
<212>  PRT
<213>  Homo Sapiens

<400>  96

Met Thr Val Pro Ile Ser Ile Thr Asn Pro Asp Leu Leu Arg His Ser 
1               5                   10                  15      


Thr Glu Leu Phe Met Asp Ser Gly Phe Ser Pro Leu Cys Gln Arg Met 
            20                  25                  30          


Gly Ala Met Val Ala Phe Arg Arg Phe Glu Asp Phe Thr Arg Asn Phe 
        35                  40                  45              


Asp Glu Val Ile Ser Cys Phe Ala Asn Val Pro Lys Asp Thr Pro Leu 
    50                  55                  60                  


Phe Ser Glu Ala Arg Thr Ser Leu Tyr Ser Glu Asp Asp Cys Lys Ser 
65                  70                  75                  80  


Leu Arg Glu Glu Pro Ile His Ile Leu Asn Val Ser Ile Gln Cys Ala 
                85                  90                  95      


Asp His Leu Glu Asp Glu Ala Leu Val Pro Ile Leu Arg Thr Phe Val 
            100                 105                 110         


Gln Ser Lys Lys Asn Ile Leu Val Asp Tyr Gly Leu Arg Arg Ile Thr 
        115                 120                 125             


Phe Leu Ile Ala Gln Glu Lys Glu Phe Pro Lys Phe Phe Thr Phe Arg 
    130                 135                 140                 


Ala Arg Asp Glu Phe Ala Glu Asp Arg Ile Tyr Arg His Leu Glu Pro 
145                 150                 155                 160 


Ala Leu Ala Phe Gln Leu Glu Leu Asn Arg Met Arg Asn Phe Asp Leu 
                165                 170                 175     


Thr Ala Val Pro Cys Ala Asn His Lys Met His Leu Tyr Leu Gly Ala 
            180                 185                 190         


Ala Lys Val Lys Glu Gly Val Glu Val Thr Asp His Arg Phe Phe Ile 
        195                 200                 205             


Arg Ala Ile Ile Arg His Ser Asp Leu Ile Thr Lys Glu Ala Ser Phe 
    210                 215                 220                 


Glu Tyr Leu Gln Asn Glu Gly Glu Arg Leu Leu Leu Glu Ala Met Asp 
225                 230                 235                 240 


Glu Leu Glu Val Ala Phe Asn Asn Thr Ser Val Arg Thr Asp Cys Asn 
                245                 250                 255     


His Ile Phe Leu Asn Phe Val Pro Thr Val Ile Met Asp Pro Phe Lys 
            260                 265                 270         


Ile Glu Glu Ser Val Arg Tyr Met Val Met Arg Tyr Gly Ser Arg Leu 
        275                 280                 285             


Trp Lys Leu Arg Val Leu Gln Ala Glu Val Lys Ile Asn Ile Arg Gln 
    290                 295                 300                 


Thr Thr Thr Gly Ser Ala Val Pro Ile Arg Leu Phe Ile Thr Asn Glu 
305                 310                 315                 320 


Ser Gly Tyr Tyr Leu Asp Ile Ser Leu Tyr Lys Glu Val Thr Asp Ser 
                325                 330                 335     


Arg Ser Gly Asn Ile Met Phe His Ser Phe Gly Asn Lys Gln Gly Pro 
            340                 345                 350         


Gln His Gly Met Leu Ile Asn Thr Pro Tyr Val Thr Lys Asp Leu Leu 
        355                 360                 365             


Gln Ala Lys Arg Phe Gln Ala Gln Thr Leu Gly Thr Thr Tyr Ile Tyr 
    370                 375                 380                 


Asp Phe Pro Glu Met Phe Arg Gln Ala Leu Phe Lys Leu Trp Gly Ser 
385                 390                 395                 400 


Pro Asp Lys Tyr Pro Lys Asp Ile Leu Thr Tyr Thr Glu Leu Val Leu 
                405                 410                 415     


Asp Ser Gln Gly Gln Leu Val Glu Met Asn Arg Leu Pro Gly Gly Asn 
            420                 425                 430         


Glu Val Gly Met Val Ala Phe Lys Met Arg Phe Lys Thr Gln Glu Tyr 
        435                 440                 445             


Pro Glu Gly Arg Asp Val Ile Val Ile Gly Asn Asp Ile Thr Phe Arg 
    450                 455                 460                 


Ile Gly Ser Phe Gly Pro Gly Glu Asp Leu Leu Tyr Leu Arg Ala Ser 
465                 470                 475                 480 


Glu Met Ala Arg Ala Glu Gly Ile Pro Lys Ile Tyr Val Ala Ala Asn 
                485                 490                 495     


Ser Gly Ala Arg Ile Gly Met Ala Glu Glu Ile Lys His Met Phe His 
            500                 505                 510         


Val Ala Trp Val Asp Pro Glu Asp Pro His Lys Gly Phe Lys Tyr Leu 
        515                 520                 525             


Tyr Leu Thr Pro Gln Asp Tyr Thr Arg Ile Ser Ser Leu Asn Ser Val 
    530                 535                 540                 


His Cys Lys His Ile Glu Glu Gly Gly Glu Ser Arg Tyr Met Ile Thr 
545                 550                 555                 560 


Asp Ile Ile Gly Lys Asp Asp Gly Leu Gly Val Glu Asn Leu Arg Gly 
                565                 570                 575     


Ser Gly Met Ile Ala Gly Glu Ser Ser Leu Ala Tyr Glu Glu Ile Val 
            580                 585                 590         


Thr Ile Ser Leu Val Thr Cys Arg Ala Ile Gly Ile Gly Ala Tyr Leu 
        595                 600                 605             


Val Arg Leu Gly Gln Arg Val Ile Gln Val Glu Asn Ser His Ile Ile 
    610                 615                 620                 


Leu Thr Gly Ala Ser Ala Leu Asn Lys Val Leu Gly Arg Glu Val Tyr 
625                 630                 635                 640 


Thr Ser Asn Asn Gln Leu Gly Gly Val Gln Ile Met His Tyr Asn Gly 
                645                 650                 655     


Val Ser His Ile Thr Val Pro Asp Asp Phe Glu Gly Val Tyr Thr Ile 
            660                 665                 670         


Leu Glu Trp Leu Ser Tyr Met Pro Lys Asp Asn His Ser Pro Val Pro 
        675                 680                 685             


Ile Ile Thr Pro Thr Asp Pro Ile Asp Arg Glu Ile Glu Phe Leu Pro 
    690                 695                 700                 


Ser Arg Ala Pro Tyr Asp Pro Arg Trp Met Leu Ala Gly Arg Pro His 
705                 710                 715                 720 


Pro Thr Leu Lys Gly Thr Trp Gln Ser Gly Phe Phe Asp His Gly Ser 
                725                 730                 735     


Phe Lys Glu Ile Met Ala Pro Trp Ala Gln Thr Val Val Thr Gly Arg 
            740                 745                 750         


Ala Arg Leu Gly Gly Ile Pro Val Gly Val Ile Ala Val Glu Thr Arg 
        755                 760                 765             


Thr Val Glu Val Ala Val Pro Ala Asp Pro Ala Asn Leu Asp Ser Glu 
    770                 775                 780                 


Ala Lys Ile Ile Gln Gln Ala Gly Gln Val Trp Phe Pro Asp Ser Ala 
785                 790                 795                 800 


Tyr Lys Thr Ala Gln Ala Val Lys Asp Phe Asn Arg Glu Lys Leu Pro 
                805                 810                 815     


Leu Met Ile Phe Ala Asn Trp Arg Gly Phe Ser Gly Gly Met Lys Gly 
            820                 825                 830         


Cys Leu Gly Thr Trp Arg Asp Val Ser Trp Trp Lys Ile Arg Ala Met 
        835                 840                 845             


Leu Pro Met His Ile Gly Glu Gly Ser Val 
    850                 855             


<210>  97
<211>  2458
<212>  PRT
<213>  Homo Sapiens

<400>  97

Met Val Leu Leu Leu Cys Leu Ser Cys Leu Ile Phe Ser Cys Leu Thr 
1               5                   10                  15      


Phe Ser Trp Leu Lys Ile Trp Gly Lys Met Thr Asp Ser Lys Pro Ile 
            20                  25                  30          


Thr Lys Ser Lys Ser Glu Ala Asn Leu Ile Pro Ser Gln Glu Pro Phe 
        35                  40                  45              


Pro Ala Ser Asp Asn Ser Gly Glu Thr Pro Gln Arg Asn Gly Glu Gly 
    50                  55                  60                  


His Thr Leu Pro Lys Thr Pro Ser Gln Ala Glu Pro Ala Ser His Lys 
65                  70                  75                  80  


Gly Pro Lys Asp Ala Gly Arg Arg Arg Asn Ser Leu Pro Pro Ser His 
                85                  90                  95      


Gln Lys Pro Pro Arg Asn Pro Leu Ser Ser Ser Asp Ala Ala Pro Ser 
            100                 105                 110         


Pro Glu Leu Gln Ala Asn Gly Thr Gly Thr Gln Gly Leu Glu Ala Thr 
        115                 120                 125             


Asp Thr Asn Gly Leu Ser Ser Ser Ala Arg Pro Gln Gly Gln Gln Ala 
    130                 135                 140                 


Gly Ser Pro Ser Lys Glu Asp Lys Lys Gln Ala Asn Ile Lys Arg Gln 
145                 150                 155                 160 


Leu Met Thr Asn Phe Ile Leu Gly Ser Phe Asp Asp Tyr Ser Ser Asp 
                165                 170                 175     


Glu Asp Ser Val Ala Gly Ser Ser Arg Glu Ser Thr Arg Lys Gly Ser 
            180                 185                 190         


Arg Ala Ser Leu Gly Ala Leu Ser Leu Glu Ala Tyr Leu Thr Thr Gly 
        195                 200                 205             


Glu Ala Glu Thr Arg Val Pro Thr Met Arg Pro Ser Met Ser Gly Leu 
    210                 215                 220                 


His Leu Val Lys Arg Gly Arg Glu His Lys Lys Leu Asp Leu His Arg 
225                 230                 235                 240 


Asp Phe Thr Val Ala Ser Pro Ala Glu Phe Val Thr Arg Phe Gly Gly 
                245                 250                 255     


Asp Arg Val Ile Glu Lys Val Leu Ile Ala Asn Asn Gly Ile Ala Ala 
            260                 265                 270         


Val Lys Cys Met Arg Ser Ile Arg Arg Trp Ala Tyr Glu Met Phe Arg 
        275                 280                 285             


Asn Glu Arg Ala Ile Arg Phe Val Val Met Val Thr Pro Glu Asp Leu 
    290                 295                 300                 


Lys Ala Asn Ala Glu Tyr Ile Lys Met Ala Asp His Tyr Val Pro Val 
305                 310                 315                 320 


Pro Gly Gly Pro Asn Asn Asn Asn Tyr Ala Asn Val Glu Leu Ile Val 
                325                 330                 335     


Asp Ile Ala Lys Arg Ile Pro Val Gln Ala Val Trp Ala Gly Trp Gly 
            340                 345                 350         


His Ala Ser Glu Asn Pro Lys Leu Pro Glu Leu Leu Cys Lys Asn Gly 
        355                 360                 365             


Val Ala Phe Leu Gly Pro Pro Ser Glu Ala Met Trp Ala Leu Gly Asp 
    370                 375                 380                 


Lys Ile Ala Ser Thr Val Val Ala Gln Thr Leu Gln Val Pro Thr Leu 
385                 390                 395                 400 


Pro Trp Ser Gly Ser Gly Leu Thr Val Glu Trp Thr Glu Asp Asp Leu 
                405                 410                 415     


Gln Gln Gly Lys Arg Ile Ser Val Pro Glu Asp Val Tyr Asp Lys Gly 
            420                 425                 430         


Cys Val Lys Asp Val Asp Glu Gly Leu Glu Ala Ala Glu Arg Ile Gly 
        435                 440                 445             


Phe Pro Leu Met Ile Lys Ala Ser Glu Gly Gly Gly Gly Lys Gly Ile 
    450                 455                 460                 


Arg Lys Ala Glu Ser Ala Glu Asp Phe Pro Ile Leu Phe Arg Gln Val 
465                 470                 475                 480 


Gln Ser Glu Ile Pro Gly Ser Pro Ile Phe Leu Met Lys Leu Ala Gln 
                485                 490                 495     


His Ala Arg His Leu Glu Val Gln Ile Leu Ala Asp Gln Tyr Gly Asn 
            500                 505                 510         


Ala Val Ser Leu Phe Gly Arg Asp Cys Ser Ile Gln Arg Arg His Gln 
        515                 520                 525             


Lys Ile Val Glu Glu Ala Pro Ala Thr Ile Ala Pro Leu Ala Ile Phe 
    530                 535                 540                 


Glu Phe Met Glu Gln Cys Ala Ile Arg Leu Ala Lys Thr Val Gly Tyr 
545                 550                 555                 560 


Val Ser Ala Gly Thr Val Glu Tyr Leu Tyr Ser Gln Asp Gly Ser Phe 
                565                 570                 575     


His Phe Leu Glu Leu Asn Pro Arg Leu Gln Val Glu His Pro Cys Thr 
            580                 585                 590         


Glu Met Ile Ala Asp Val Asn Leu Pro Ala Ala Gln Leu Gln Ile Ala 
        595                 600                 605             


Met Gly Val Pro Leu His Arg Leu Lys Asp Ile Arg Leu Leu Tyr Gly 
    610                 615                 620                 


Glu Ser Pro Trp Gly Val Thr Pro Ile Ser Phe Glu Thr Pro Ser Asn 
625                 630                 635                 640 


Pro Pro Leu Ala Arg Gly His Val Ile Ala Ala Arg Ile Thr Ser Glu 
                645                 650                 655     


Asn Pro Asp Glu Gly Phe Lys Pro Ser Ser Gly Thr Val Gln Glu Leu 
            660                 665                 670         


Asn Phe Arg Ser Ser Lys Asn Val Trp Gly Tyr Phe Ser Val Ala Ala 
        675                 680                 685             


Thr Gly Gly Leu His Glu Phe Ala Asp Ser Gln Phe Gly His Cys Phe 
    690                 695                 700                 


Ser Trp Gly Glu Asn Arg Glu Glu Ala Ile Ser Asn Met Val Val Ala 
705                 710                 715                 720 


Leu Lys Glu Leu Ser Ile Arg Gly Asp Phe Arg Thr Thr Val Glu Tyr 
                725                 730                 735     


Leu Ile Asn Leu Leu Glu Thr Glu Ser Phe Gln Asn Asn Asp Ile Asp 
            740                 745                 750         


Thr Gly Trp Leu Asp Tyr Leu Ile Ala Glu Lys Val Gln Ala Glu Lys 
        755                 760                 765             


Pro Asp Ile Met Leu Gly Val Val Cys Gly Ala Leu Asn Val Ala Asp 
    770                 775                 780                 


Ala Met Phe Arg Thr Cys Met Thr Asp Phe Leu His Ser Leu Glu Arg 
785                 790                 795                 800 


Gly Gln Val Leu Pro Ala Asp Ser Leu Leu Asn Leu Val Asp Val Glu 
                805                 810                 815     


Leu Ile Tyr Gly Gly Val Lys Tyr Ile Leu Lys Val Ala Arg Gln Ser 
            820                 825                 830         


Leu Thr Met Phe Val Leu Ile Met Asn Gly Cys His Ile Glu Ile Asp 
        835                 840                 845             


Ala His Arg Leu Asn Asp Gly Gly Leu Leu Leu Ser Tyr Asn Gly Asn 
    850                 855                 860                 


Ser Tyr Thr Thr Tyr Met Lys Glu Glu Val Asp Ser Tyr Arg Ile Thr 
865                 870                 875                 880 


Ile Gly Asn Lys Thr Cys Val Phe Glu Lys Glu Asn Asp Pro Thr Val 
                885                 890                 895     


Leu Arg Ser Pro Ser Ala Gly Lys Leu Thr Gln Tyr Thr Val Glu Asp 
            900                 905                 910         


Gly Gly His Val Glu Ala Gly Ser Ser Tyr Ala Glu Met Glu Val Met 
        915                 920                 925             


Lys Met Ile Met Thr Leu Asn Val Gln Glu Arg Gly Arg Val Lys Tyr 
    930                 935                 940                 


Ile Lys Arg Pro Gly Ala Val Leu Glu Ala Gly Cys Val Val Ala Arg 
945                 950                 955                 960 


Leu Glu Leu Asp Asp Pro Ser Lys Val His Pro Ala Glu Pro Phe Thr 
                965                 970                 975     


Gly Glu Leu Pro Ala Gln Gln Thr Leu Pro Ile Leu Gly Glu Lys Leu 
            980                 985                 990         


His Gln Val Phe His Ser Val Leu  Glu Asn Leu Thr Asn  Val Met Ser 
        995                 1000                 1005             


Gly Phe  Cys Leu Pro Glu Pro  Val Phe Ser Ile Lys  Leu Lys Glu 
    1010                 1015                 1020             


Trp Val  Gln Lys Leu Met Met  Thr Leu Arg His Pro  Ser Leu Pro 
    1025                 1030                 1035             


Leu Leu  Glu Leu Gln Glu Ile  Met Thr Ser Val Ala  Gly Arg Ile 
    1040                 1045                 1050             


Pro Ala  Pro Val Glu Lys Ser  Val Arg Arg Val Met  Ala Gln Tyr 
    1055                 1060                 1065             


Ala Ser  Asn Ile Thr Ser Val  Leu Cys Gln Phe Pro  Ser Gln Gln 
    1070                 1075                 1080             


Ile Ala  Thr Ile Leu Asp Cys  His Ala Ala Thr Leu  Gln Arg Lys 
    1085                 1090                 1095             


Ala Asp  Arg Glu Val Phe Phe  Ile Asn Thr Gln Ser  Ile Val Gln 
    1100                 1105                 1110             


Leu Val  Gln Arg Tyr Arg Ser  Gly Ile Arg Gly Tyr  Met Lys Thr 
    1115                 1120                 1125             


Val Val  Leu Asp Leu Leu Arg  Arg Tyr Leu Arg Val  Glu His His 
    1130                 1135                 1140             


Phe Gln  Gln Ala His Tyr Asp  Lys Cys Val Ile Asn  Leu Arg Glu 
    1145                 1150                 1155             


Gln Phe  Lys Pro Asp Met Ser  Gln Val Leu Asp Cys  Ile Phe Ser 
    1160                 1165                 1170             


His Ala  Gln Val Ala Lys Lys  Asn Gln Leu Val Ile  Met Leu Ile 
    1175                 1180                 1185             


Asp Glu  Leu Cys Gly Pro Asp  Pro Ser Leu Ser Asp  Glu Leu Ile 
    1190                 1195                 1200             


Ser Ile  Leu Asn Glu Leu Thr  Gln Leu Ser Lys Ser  Glu His Cys 
    1205                 1210                 1215             


Lys Val  Ala Leu Arg Ala Arg  Gln Ile Leu Ile Ala  Ser His Leu 
    1220                 1225                 1230             


Pro Ser  Tyr Glu Leu Arg His  Asn Gln Val Glu Ser  Ile Phe Leu 
    1235                 1240                 1245             


Ser Ala  Ile Asp Met Tyr Gly  His Gln Phe Cys Pro  Glu Asn Leu 
    1250                 1255                 1260             


Lys Lys  Leu Ile Leu Ser Glu  Thr Thr Ile Phe Asp  Val Leu Pro 
    1265                 1270                 1275             


Thr Phe  Phe Tyr His Ala Asn  Lys Val Val Cys Met  Ala Ser Leu 
    1280                 1285                 1290             


Glu Val  Tyr Val Arg Arg Gly  Tyr Ile Ala Tyr Glu  Leu Asn Ser 
    1295                 1300                 1305             


Leu Gln  His Arg Gln Leu Pro  Asp Gly Thr Cys Val  Val Glu Phe 
    1310                 1315                 1320             


Gln Phe  Met Leu Pro Ser Ser  His Pro Asn Arg Met  Thr Val Pro 
    1325                 1330                 1335             


Ile Ser  Ile Thr Asn Pro Asp  Leu Leu Arg His Ser  Thr Glu Leu 
    1340                 1345                 1350             


Phe Met  Asp Ser Gly Phe Ser  Pro Leu Cys Gln Arg  Met Gly Ala 
    1355                 1360                 1365             


Met Val  Ala Phe Arg Arg Phe  Glu Asp Phe Thr Arg  Asn Phe Asp 
    1370                 1375                 1380             


Glu Val  Ile Ser Cys Phe Ala  Asn Val Pro Lys Asp  Thr Pro Leu 
    1385                 1390                 1395             


Phe Ser  Glu Ala Arg Thr Ser  Leu Tyr Ser Glu Asp  Asp Cys Lys 
    1400                 1405                 1410             


Ser Leu  Arg Glu Glu Pro Ile  His Ile Leu Asn Val  Ser Ile Gln 
    1415                 1420                 1425             


Cys Ala  Asp His Leu Glu Asp  Glu Ala Leu Val Pro  Ile Leu Arg 
    1430                 1435                 1440             


Thr Phe  Val Gln Ser Lys Lys  Asn Ile Leu Val Asp  Tyr Gly Leu 
    1445                 1450                 1455             


Arg Arg  Ile Thr Phe Leu Ile  Ala Gln Glu Lys Glu  Phe Pro Lys 
    1460                 1465                 1470             


Phe Phe  Thr Phe Arg Ala Arg  Asp Glu Phe Ala Glu  Asp Arg Ile 
    1475                 1480                 1485             


Tyr Arg  His Leu Glu Pro Ala  Leu Ala Phe Gln Leu  Glu Leu Asn 
    1490                 1495                 1500             


Arg Met  Arg Asn Phe Asp Leu  Thr Ala Val Pro Cys  Ala Asn His 
    1505                 1510                 1515             


Lys Met  His Leu Tyr Leu Gly  Ala Ala Lys Val Lys  Glu Gly Val 
    1520                 1525                 1530             


Glu Val  Thr Asp His Arg Phe  Phe Ile Arg Ala Ile  Ile Arg His 
    1535                 1540                 1545             


Ser Asp  Leu Ile Thr Lys Glu  Ala Ser Phe Glu Tyr  Leu Gln Asn 
    1550                 1555                 1560             


Glu Gly  Glu Arg Leu Leu Leu  Glu Ala Met Asp Glu  Leu Glu Val 
    1565                 1570                 1575             


Ala Phe  Asn Asn Thr Ser Val  Arg Thr Asp Cys Asn  His Ile Phe 
    1580                 1585                 1590             


Leu Asn  Phe Val Pro Thr Val  Ile Met Asp Pro Phe  Lys Ile Glu 
    1595                 1600                 1605             


Glu Ser  Val Arg Tyr Met Val  Met Arg Tyr Gly Ser  Arg Leu Trp 
    1610                 1615                 1620             


Lys Leu  Arg Val Leu Gln Ala  Glu Val Lys Ile Asn  Ile Arg Gln 
    1625                 1630                 1635             


Thr Thr  Thr Gly Ser Ala Val  Pro Ile Arg Leu Phe  Ile Thr Asn 
    1640                 1645                 1650             


Glu Ser  Gly Tyr Tyr Leu Asp  Ile Ser Leu Tyr Lys  Glu Val Thr 
    1655                 1660                 1665             


Asp Ser  Arg Ser Gly Asn Ile  Met Phe His Ser Phe  Gly Asn Lys 
    1670                 1675                 1680             


Gln Gly  Pro Gln His Gly Met  Leu Ile Asn Thr Pro  Tyr Val Thr 
    1685                 1690                 1695             


Lys Asp  Leu Leu Gln Ala Lys  Arg Phe Gln Ala Gln  Thr Leu Gly 
    1700                 1705                 1710             


Thr Thr  Tyr Ile Tyr Asp Phe  Pro Glu Met Phe Arg  Gln Ala Leu 
    1715                 1720                 1725             


Phe Lys  Leu Trp Gly Ser Pro  Asp Lys Tyr Pro Lys  Asp Ile Leu 
    1730                 1735                 1740             


Thr Tyr  Thr Glu Leu Val Leu  Asp Ser Gln Gly Gln  Leu Val Glu 
    1745                 1750                 1755             


Met Asn  Arg Leu Pro Gly Gly  Asn Glu Val Gly Met  Val Ala Phe 
    1760                 1765                 1770             


Lys Met  Arg Phe Lys Thr Gln  Glu Tyr Pro Glu Gly  Arg Asp Val 
    1775                 1780                 1785             


Ile Val  Ile Gly Asn Asp Ile  Thr Phe Arg Ile Gly  Ser Phe Gly 
    1790                 1795                 1800             


Pro Gly  Glu Asp Leu Leu Tyr  Leu Arg Ala Ser Glu  Met Ala Arg 
    1805                 1810                 1815             


Ala Glu  Gly Ile Pro Lys Ile  Tyr Val Ala Ala Asn  Ser Gly Ala 
    1820                 1825                 1830             


Arg Ile  Gly Met Ala Glu Glu  Ile Lys His Met Phe  His Val Ala 
    1835                 1840                 1845             


Trp Val  Asp Pro Glu Asp Pro  His Lys Gly Phe Lys  Tyr Leu Tyr 
    1850                 1855                 1860             


Leu Thr  Pro Gln Asp Tyr Thr  Arg Ile Ser Ser Leu  Asn Ser Val 
    1865                 1870                 1875             


His Cys  Lys His Ile Glu Glu  Gly Gly Glu Ser Arg  Tyr Met Ile 
    1880                 1885                 1890             


Thr Asp  Ile Ile Gly Lys Asp  Asp Gly Leu Gly Val  Glu Asn Leu 
    1895                 1900                 1905             


Arg Gly  Ser Gly Met Ile Ala  Gly Glu Ser Ser Leu  Ala Tyr Glu 
    1910                 1915                 1920             


Glu Ile  Val Thr Ile Ser Leu  Val Thr Cys Arg Ala  Ile Gly Ile 
    1925                 1930                 1935             


Gly Ala  Tyr Leu Val Arg Leu  Gly Gln Arg Val Ile  Gln Val Glu 
    1940                 1945                 1950             


Asn Ser  His Ile Ile Leu Thr  Gly Ala Ser Ala Leu  Asn Lys Val 
    1955                 1960                 1965             


Leu Gly  Arg Glu Val Tyr Thr  Ser Asn Asn Gln Leu  Gly Gly Val 
    1970                 1975                 1980             


Gln Ile  Met His Tyr Asn Gly  Val Ser His Ile Thr  Val Pro Asp 
    1985                 1990                 1995             


Asp Phe  Glu Gly Val Tyr Thr  Ile Leu Glu Trp Leu  Ser Tyr Met 
    2000                 2005                 2010             


Pro Lys  Asp Asn His Ser Pro  Val Pro Ile Ile Thr  Pro Thr Asp 
    2015                 2020                 2025             


Pro Ile  Asp Arg Glu Ile Glu  Phe Leu Pro Ser Arg  Ala Pro Tyr 
    2030                 2035                 2040             


Asp Pro  Arg Trp Met Leu Ala  Gly Arg Pro His Pro  Thr Leu Lys 
    2045                 2050                 2055             


Gly Thr  Trp Gln Ser Gly Phe  Phe Asp His Gly Ser  Phe Lys Glu 
    2060                 2065                 2070             


Ile Met  Ala Pro Trp Ala Gln  Thr Val Val Thr Gly  Arg Ala Arg 
    2075                 2080                 2085             


Leu Gly  Gly Ile Pro Val Gly  Val Ile Ala Val Glu  Thr Arg Thr 
    2090                 2095                 2100             


Val Glu  Val Ala Val Pro Ala  Asp Pro Ala Asn Leu  Asp Ser Glu 
    2105                 2110                 2115             


Ala Lys  Ile Ile Gln Gln Ala  Gly Gln Val Trp Phe  Pro Asp Ser 
    2120                 2125                 2130             


Ala Tyr  Lys Thr Ala Gln Ala  Val Lys Asp Phe Asn  Arg Glu Lys 
    2135                 2140                 2145             


Leu Pro  Leu Met Ile Phe Ala  Asn Trp Arg Gly Phe  Ser Gly Gly 
    2150                 2155                 2160             


Met Lys  Asp Met Tyr Asp Gln  Val Leu Lys Phe Gly  Ala Tyr Ile 
    2165                 2170                 2175             


Val Asp  Gly Leu Arg Gln Tyr  Lys Gln Pro Ile Leu  Ile Tyr Ile 
    2180                 2185                 2190             


Pro Pro  Tyr Ala Glu Leu Arg  Gly Gly Ser Trp Val  Val Ile Asp 
    2195                 2200                 2205             


Ala Thr  Ile Asn Pro Leu Cys  Ile Glu Met Tyr Ala  Asp Lys Glu 
    2210                 2215                 2220             


Ser Arg  Gly Gly Val Leu Glu  Pro Glu Gly Thr Val  Glu Ile Lys 
    2225                 2230                 2235             


Phe Arg  Lys Lys Asp Leu Ile  Lys Ser Met Arg Arg  Ile Asp Pro 
    2240                 2245                 2250             


Ala Tyr  Lys Lys Leu Met Glu  Gln Leu Gly Glu Pro  Asp Leu Ser 
    2255                 2260                 2265             


Asp Lys  Asp Arg Lys Asp Leu  Glu Gly Arg Leu Lys  Ala Arg Glu 
    2270                 2275                 2280             


Asp Leu  Leu Leu Pro Ile Tyr  His Gln Val Ala Val  Gln Phe Ala 
    2285                 2290                 2295             


Asp Phe  His Asp Thr Pro Gly  Arg Met Leu Glu Lys  Gly Val Ile 
    2300                 2305                 2310             


Ser Asp  Ile Leu Glu Trp Lys  Thr Ala Arg Thr Phe  Leu Tyr Trp 
    2315                 2320                 2325             


Arg Leu  Arg Arg Leu Leu Leu  Glu Asp Gln Val Lys  Gln Glu Ile 
    2330                 2335                 2340             


Leu Gln  Ala Ser Gly Glu Leu  Ser His Val His Ile  Gln Ser Met 
    2345                 2350                 2355             


Leu Arg  Arg Trp Phe Val Glu  Thr Glu Gly Ala Val  Lys Ala Tyr 
    2360                 2365                 2370             


Leu Trp  Asp Asn Asn Gln Val  Val Val Gln Trp Leu  Glu Gln His 
    2375                 2380                 2385             


Trp Gln  Ala Gly Asp Gly Pro  Arg Ser Thr Ile Arg  Glu Asn Ile 
    2390                 2395                 2400             


Thr Tyr  Leu Lys His Asp Ser  Val Leu Lys Thr Ile  Arg Gly Leu 
    2405                 2410                 2415             


Val Glu  Glu Asn Pro Glu Val  Ala Val Asp Cys Val  Ile Tyr Leu 
    2420                 2425                 2430             


Ser Gln  His Ile Ser Pro Ala  Glu Arg Ala Gln Val  Val His Leu 
    2435                 2440                 2445             


Leu Ser  Thr Met Asp Ser Pro  Ala Ser Thr 
    2450                 2455             


<210>  98
<211>  2458
<212>  PRT
<213>  Homo Sapiens

<400>  98

Met Val Leu Leu Leu Cys Leu Ser Cys Leu Ile Phe Ser Cys Leu Thr 
1               5                   10                  15      


Phe Ser Trp Leu Lys Ile Trp Gly Lys Met Thr Asp Ser Lys Pro Ile 
            20                  25                  30          


Thr Lys Ser Lys Ser Glu Ala Asn Leu Ile Pro Ser Gln Glu Pro Phe 
        35                  40                  45              


Pro Ala Ser Asp Asn Ser Gly Glu Thr Pro Gln Arg Asn Gly Glu Gly 
    50                  55                  60                  


His Thr Leu Pro Lys Thr Pro Ser Gln Ala Glu Pro Ala Ser His Lys 
65                  70                  75                  80  


Gly Pro Lys Asp Ala Gly Arg Arg Arg Asn Ser Leu Pro Pro Ser His 
                85                  90                  95      


Gln Lys Pro Pro Arg Asn Pro Leu Ser Ser Ser Asp Ala Ala Pro Ser 
            100                 105                 110         


Pro Glu Leu Gln Ala Asn Gly Thr Gly Thr Gln Gly Leu Glu Ala Thr 
        115                 120                 125             


Asp Thr Asn Gly Leu Ser Ser Ser Ala Arg Pro Gln Gly Gln Gln Ala 
    130                 135                 140                 


Gly Ser Pro Ser Lys Glu Asp Lys Lys Gln Ala Asn Ile Lys Arg Gln 
145                 150                 155                 160 


Leu Met Thr Asn Phe Ile Leu Gly Ser Phe Asp Asp Tyr Ser Ser Asp 
                165                 170                 175     


Glu Asp Ser Val Ala Gly Ser Ser Arg Glu Ser Thr Arg Lys Gly Ser 
            180                 185                 190         


Arg Ala Ser Leu Gly Ala Leu Ser Leu Glu Ala Tyr Leu Thr Thr Gly 
        195                 200                 205             


Glu Ala Glu Thr Arg Val Pro Thr Met Arg Pro Ser Met Ser Gly Leu 
    210                 215                 220                 


His Leu Val Lys Arg Gly Arg Glu His Lys Lys Leu Asp Leu His Arg 
225                 230                 235                 240 


Asp Phe Thr Val Ala Ser Pro Ala Glu Phe Val Thr Arg Phe Gly Gly 
                245                 250                 255     


Asp Arg Val Ile Glu Lys Val Leu Ile Ala Asn Asn Gly Ile Ala Ala 
            260                 265                 270         


Val Lys Cys Met Arg Ser Ile Arg Arg Trp Ala Tyr Glu Met Phe Arg 
        275                 280                 285             


Asn Glu Arg Ala Ile Arg Phe Val Val Met Val Thr Pro Glu Asp Leu 
    290                 295                 300                 


Lys Ala Asn Ala Glu Tyr Ile Lys Met Ala Asp His Tyr Val Pro Val 
305                 310                 315                 320 


Pro Gly Gly Pro Asn Asn Asn Asn Tyr Ala Asn Val Glu Leu Ile Val 
                325                 330                 335     


Asp Ile Ala Lys Arg Ile Pro Val Gln Ala Val Trp Ala Gly Trp Gly 
            340                 345                 350         


His Ala Ser Glu Asn Pro Lys Leu Pro Glu Leu Leu Cys Lys Asn Gly 
        355                 360                 365             


Val Ala Phe Leu Gly Pro Pro Ser Glu Ala Met Trp Ala Leu Gly Asp 
    370                 375                 380                 


Lys Ile Ala Ser Thr Val Val Ala Gln Thr Leu Gln Val Pro Thr Leu 
385                 390                 395                 400 


Pro Trp Ser Gly Ser Gly Leu Thr Val Glu Trp Thr Glu Asp Asp Leu 
                405                 410                 415     


Gln Gln Gly Lys Arg Ile Ser Val Pro Glu Asp Val Tyr Asp Lys Gly 
            420                 425                 430         


Cys Val Lys Asp Val Asp Glu Gly Leu Glu Ala Ala Glu Arg Ile Gly 
        435                 440                 445             


Phe Pro Leu Met Ile Lys Ala Ser Glu Gly Gly Gly Gly Lys Gly Ile 
    450                 455                 460                 


Arg Lys Ala Glu Ser Ala Glu Asp Phe Pro Ile Leu Phe Arg Gln Val 
465                 470                 475                 480 


Gln Ser Glu Ile Pro Gly Ser Pro Ile Phe Leu Met Lys Leu Ala Gln 
                485                 490                 495     


His Ala Arg His Leu Glu Val Gln Ile Leu Ala Asp Gln Tyr Gly Asn 
            500                 505                 510         


Ala Val Ser Leu Phe Gly Arg Asp Cys Ser Ile Gln Arg Arg His Gln 
        515                 520                 525             


Lys Ile Val Glu Glu Ala Pro Ala Thr Ile Ala Pro Leu Ala Ile Phe 
    530                 535                 540                 


Glu Phe Met Glu Gln Cys Ala Ile Arg Leu Ala Lys Thr Val Gly Tyr 
545                 550                 555                 560 


Val Ser Ala Gly Thr Val Glu Tyr Leu Tyr Ser Gln Asp Gly Ser Phe 
                565                 570                 575     


His Phe Leu Glu Leu Asn Pro Arg Leu Gln Val Glu His Pro Cys Thr 
            580                 585                 590         


Glu Met Ile Ala Asp Val Asn Leu Pro Ala Ala Gln Leu Gln Ile Ala 
        595                 600                 605             


Met Gly Val Pro Leu His Arg Leu Lys Asp Ile Arg Leu Leu Tyr Gly 
    610                 615                 620                 


Glu Ser Pro Trp Gly Val Thr Pro Ile Ser Phe Glu Thr Pro Ser Asn 
625                 630                 635                 640 


Pro Pro Leu Ala Arg Gly His Val Ile Ala Ala Arg Ile Thr Ser Glu 
                645                 650                 655     


Asn Pro Asp Glu Gly Phe Lys Pro Ser Ser Gly Thr Val Gln Glu Leu 
            660                 665                 670         


Asn Phe Arg Ser Ser Lys Asn Val Trp Gly Tyr Phe Ser Val Ala Ala 
        675                 680                 685             


Thr Gly Gly Leu His Glu Phe Ala Asp Ser Gln Phe Gly His Cys Phe 
    690                 695                 700                 


Ser Trp Gly Glu Asn Arg Glu Glu Ala Ile Ser Asn Met Val Val Ala 
705                 710                 715                 720 


Leu Lys Glu Leu Ser Ile Arg Gly Asp Phe Arg Thr Thr Val Glu Tyr 
                725                 730                 735     


Leu Ile Asn Leu Leu Glu Thr Glu Ser Phe Gln Asn Asn Asp Ile Asp 
            740                 745                 750         


Thr Gly Trp Leu Asp Tyr Leu Ile Ala Glu Lys Val Gln Ala Glu Lys 
        755                 760                 765             


Pro Asp Ile Met Leu Gly Val Val Cys Gly Ala Leu Asn Val Ala Asp 
    770                 775                 780                 


Ala Met Phe Arg Thr Cys Met Thr Asp Phe Leu His Ser Leu Glu Arg 
785                 790                 795                 800 


Gly Gln Val Leu Pro Ala Asp Ser Leu Leu Asn Leu Val Asp Val Glu 
                805                 810                 815     


Leu Ile Tyr Gly Gly Val Lys Tyr Ile Leu Lys Val Ala Arg Gln Ser 
            820                 825                 830         


Leu Thr Met Phe Val Leu Ile Met Asn Gly Cys His Ile Glu Ile Asp 
        835                 840                 845             


Ala His Arg Leu Asn Asp Gly Gly Leu Leu Leu Ser Tyr Asn Gly Asn 
    850                 855                 860                 


Ser Tyr Thr Thr Tyr Met Lys Glu Glu Val Asp Ser Tyr Arg Ile Thr 
865                 870                 875                 880 


Ile Gly Asn Lys Thr Cys Val Phe Glu Lys Glu Asn Asp Pro Thr Val 
                885                 890                 895     


Leu Arg Ser Pro Ser Ala Gly Lys Leu Thr Gln Tyr Thr Val Glu Asp 
            900                 905                 910         


Gly Gly His Val Glu Ala Gly Ser Ser Tyr Ala Glu Met Glu Val Met 
        915                 920                 925             


Lys Met Ile Met Thr Leu Asn Val Gln Glu Arg Gly Arg Val Lys Tyr 
    930                 935                 940                 


Ile Lys Arg Pro Gly Ala Val Leu Glu Ala Gly Cys Val Val Ala Arg 
945                 950                 955                 960 


Leu Glu Leu Asp Asp Pro Ser Lys Val His Pro Ala Glu Pro Phe Thr 
                965                 970                 975     


Gly Glu Leu Pro Ala Gln Gln Thr Leu Pro Ile Leu Gly Glu Lys Leu 
            980                 985                 990         


His Gln Val Phe His Ser Val Leu  Glu Asn Leu Thr Asn  Val Met Ser 
        995                 1000                 1005             


Gly Phe  Cys Leu Pro Glu Pro  Val Phe Ser Ile Lys  Leu Lys Glu 
    1010                 1015                 1020             


Trp Val  Gln Lys Leu Met Met  Thr Leu Arg His Pro  Ser Leu Pro 
    1025                 1030                 1035             


Leu Leu  Glu Leu Gln Glu Ile  Met Thr Ser Val Ala  Gly Arg Ile 
    1040                 1045                 1050             


Pro Ala  Pro Val Glu Lys Ser  Val Arg Arg Val Met  Ala Gln Tyr 
    1055                 1060                 1065             


Ala Ser  Asn Ile Thr Ser Val  Leu Cys Gln Phe Pro  Ser Gln Gln 
    1070                 1075                 1080             


Ile Ala  Thr Ile Leu Asp Cys  His Ala Ala Thr Leu  Gln Arg Lys 
    1085                 1090                 1095             


Ala Asp  Arg Glu Val Phe Phe  Ile Asn Thr Gln Ser  Ile Val Gln 
    1100                 1105                 1110             


Leu Val  Gln Arg Tyr Arg Ser  Gly Ile Arg Gly Tyr  Met Lys Thr 
    1115                 1120                 1125             


Val Val  Leu Asp Leu Leu Arg  Arg Tyr Leu Arg Val  Glu His His 
    1130                 1135                 1140             


Phe Gln  Gln Ala His Tyr Asp  Lys Cys Val Ile Asn  Leu Arg Glu 
    1145                 1150                 1155             


Gln Phe  Lys Pro Asp Met Ser  Gln Val Leu Asp Cys  Ile Phe Ser 
    1160                 1165                 1170             


His Ala  Gln Val Ala Lys Lys  Asn Gln Leu Val Ile  Met Leu Ile 
    1175                 1180                 1185             


Asp Glu  Leu Cys Gly Pro Asp  Pro Ser Leu Ser Asp  Glu Leu Ile 
    1190                 1195                 1200             


Ser Ile  Leu Asn Glu Leu Thr  Gln Leu Ser Lys Ser  Glu His Cys 
    1205                 1210                 1215             


Lys Val  Ala Leu Arg Ala Arg  Gln Ile Leu Ile Ala  Ser His Leu 
    1220                 1225                 1230             


Pro Ser  Tyr Glu Leu Arg His  Asn Gln Val Glu Ser  Ile Phe Leu 
    1235                 1240                 1245             


Ser Ala  Ile Asp Met Tyr Gly  His Gln Phe Cys Pro  Glu Asn Leu 
    1250                 1255                 1260             


Lys Lys  Leu Ile Leu Ser Glu  Thr Thr Ile Phe Asp  Val Leu Pro 
    1265                 1270                 1275             


Thr Phe  Phe Tyr His Ala Asn  Lys Val Val Cys Met  Ala Ser Leu 
    1280                 1285                 1290             


Glu Val  Tyr Val Arg Arg Gly  Tyr Ile Ala Tyr Glu  Leu Asn Ser 
    1295                 1300                 1305             


Leu Gln  His Arg Gln Leu Pro  Asp Gly Thr Cys Val  Val Glu Phe 
    1310                 1315                 1320             


Gln Phe  Met Leu Pro Ser Ser  His Pro Asn Arg Met  Thr Val Pro 
    1325                 1330                 1335             


Ile Ser  Ile Thr Asn Pro Asp  Leu Leu Arg His Ser  Thr Glu Leu 
    1340                 1345                 1350             


Phe Met  Asp Ser Gly Phe Ser  Pro Leu Cys Gln Arg  Met Gly Ala 
    1355                 1360                 1365             


Met Val  Ala Phe Arg Arg Phe  Glu Asp Phe Thr Arg  Asn Phe Asp 
    1370                 1375                 1380             


Glu Val  Ile Ser Cys Phe Ala  Asn Val Pro Lys Asp  Thr Pro Leu 
    1385                 1390                 1395             


Phe Ser  Glu Ala Arg Thr Ser  Leu Tyr Ser Glu Asp  Asp Cys Lys 
    1400                 1405                 1410             


Ser Leu  Arg Glu Glu Pro Ile  His Ile Leu Asn Val  Ser Ile Gln 
    1415                 1420                 1425             


Cys Ala  Asp His Leu Glu Asp  Glu Ala Leu Val Pro  Ile Leu Arg 
    1430                 1435                 1440             


Thr Phe  Val Gln Ser Lys Lys  Asn Ile Leu Val Asp  Tyr Gly Leu 
    1445                 1450                 1455             


Arg Arg  Ile Thr Phe Leu Ile  Ala Gln Glu Lys Glu  Phe Pro Lys 
    1460                 1465                 1470             


Phe Phe  Thr Phe Arg Ala Arg  Asp Glu Phe Ala Glu  Asp Arg Ile 
    1475                 1480                 1485             


Tyr Arg  His Leu Glu Pro Ala  Leu Ala Phe Gln Leu  Glu Leu Asn 
    1490                 1495                 1500             


Arg Met  Arg Asn Phe Asp Leu  Thr Ala Val Pro Cys  Ala Asn His 
    1505                 1510                 1515             


Lys Met  His Leu Tyr Leu Gly  Ala Ala Lys Val Lys  Glu Gly Val 
    1520                 1525                 1530             


Glu Val  Thr Asp His Arg Phe  Phe Ile Arg Ala Ile  Ile Arg His 
    1535                 1540                 1545             


Ser Asp  Leu Ile Thr Lys Glu  Ala Ser Phe Glu Tyr  Leu Gln Asn 
    1550                 1555                 1560             


Glu Gly  Glu Arg Leu Leu Leu  Glu Ala Met Asp Glu  Leu Glu Val 
    1565                 1570                 1575             


Ala Phe  Asn Asn Thr Ser Val  Arg Thr Asp Cys Asn  His Ile Phe 
    1580                 1585                 1590             


Leu Asn  Phe Val Pro Thr Val  Ile Met Asp Pro Phe  Lys Ile Glu 
    1595                 1600                 1605             


Glu Ser  Val Arg Tyr Met Val  Met Arg Tyr Gly Ser  Arg Leu Trp 
    1610                 1615                 1620             


Lys Leu  Arg Val Leu Gln Ala  Glu Val Lys Ile Asn  Ile Arg Gln 
    1625                 1630                 1635             


Thr Thr  Thr Gly Ser Ala Val  Pro Ile Arg Leu Phe  Ile Thr Asn 
    1640                 1645                 1650             


Glu Ser  Gly Tyr Tyr Leu Asp  Ile Ser Leu Tyr Lys  Glu Val Thr 
    1655                 1660                 1665             


Asp Ser  Arg Ser Gly Asn Ile  Met Phe His Ser Phe  Gly Asn Lys 
    1670                 1675                 1680             


Gln Gly  Pro Gln His Gly Met  Leu Ile Asn Thr Pro  Tyr Val Thr 
    1685                 1690                 1695             


Lys Asp  Leu Leu Gln Ala Lys  Arg Phe Gln Ala Gln  Thr Leu Gly 
    1700                 1705                 1710             


Thr Thr  Tyr Ile Tyr Asp Phe  Pro Glu Met Phe Arg  Gln Ala Leu 
    1715                 1720                 1725             


Phe Lys  Leu Trp Gly Ser Pro  Asp Lys Tyr Pro Lys  Asp Ile Leu 
    1730                 1735                 1740             


Thr Tyr  Thr Glu Leu Val Leu  Asp Ser Gln Gly Gln  Leu Val Glu 
    1745                 1750                 1755             


Met Asn  Arg Leu Pro Gly Gly  Asn Glu Val Gly Met  Val Ala Phe 
    1760                 1765                 1770             


Lys Met  Arg Phe Lys Thr Gln  Glu Tyr Pro Glu Gly  Arg Asp Val 
    1775                 1780                 1785             


Ile Val  Ile Gly Asn Asp Ile  Thr Phe Arg Ile Gly  Ser Phe Gly 
    1790                 1795                 1800             


Pro Gly  Glu Asp Leu Leu Tyr  Leu Arg Ala Ser Glu  Met Ala Arg 
    1805                 1810                 1815             


Ala Glu  Gly Ile Pro Lys Ile  Tyr Val Ala Ala Asn  Ser Gly Ala 
    1820                 1825                 1830             


Arg Ile  Gly Met Ala Glu Glu  Ile Lys His Met Phe  His Val Ala 
    1835                 1840                 1845             


Trp Val  Asp Pro Glu Asp Pro  His Lys Gly Phe Lys  Tyr Leu Tyr 
    1850                 1855                 1860             


Leu Thr  Pro Gln Asp Tyr Thr  Arg Ile Ser Ser Leu  Asn Ser Val 
    1865                 1870                 1875             


His Cys  Lys His Ile Glu Glu  Gly Gly Glu Ser Arg  Tyr Met Ile 
    1880                 1885                 1890             


Thr Asp  Ile Ile Gly Lys Asp  Asp Gly Leu Gly Val  Glu Asn Leu 
    1895                 1900                 1905             


Arg Gly  Ser Gly Met Ile Ala  Gly Glu Ser Ser Leu  Ala Tyr Glu 
    1910                 1915                 1920             


Glu Ile  Val Thr Ile Ser Leu  Val Thr Cys Arg Ala  Ile Gly Ile 
    1925                 1930                 1935             


Gly Ala  Tyr Leu Val Arg Leu  Gly Gln Arg Val Ile  Gln Val Glu 
    1940                 1945                 1950             


Asn Ser  His Ile Ile Leu Thr  Gly Ala Ser Ala Leu  Asn Lys Val 
    1955                 1960                 1965             


Leu Gly  Arg Glu Val Tyr Thr  Ser Asn Asn Gln Leu  Gly Gly Val 
    1970                 1975                 1980             


Gln Ile  Met His Tyr Asn Gly  Val Ser His Ile Thr  Val Pro Asp 
    1985                 1990                 1995             


Asp Phe  Glu Gly Val Tyr Thr  Ile Leu Glu Trp Leu  Ser Tyr Met 
    2000                 2005                 2010             


Pro Lys  Asp Asn His Ser Pro  Val Pro Ile Ile Thr  Pro Thr Asp 
    2015                 2020                 2025             


Pro Ile  Asp Arg Glu Ile Glu  Phe Leu Pro Ser Arg  Ala Pro Tyr 
    2030                 2035                 2040             


Asp Pro  Arg Trp Met Leu Ala  Gly Arg Pro His Pro  Thr Leu Lys 
    2045                 2050                 2055             


Gly Thr  Trp Gln Ser Gly Phe  Phe Asp His Gly Ser  Phe Lys Glu 
    2060                 2065                 2070             


Ile Met  Ala Pro Trp Ala Gln  Thr Val Val Thr Gly  Arg Ala Arg 
    2075                 2080                 2085             


Leu Gly  Gly Ile Pro Val Gly  Val Ile Ala Val Glu  Thr Arg Thr 
    2090                 2095                 2100             


Val Glu  Val Ala Val Pro Ala  Asp Pro Ala Asn Leu  Asp Ser Glu 
    2105                 2110                 2115             


Ala Lys  Ile Ile Gln Gln Ala  Gly Gln Val Trp Phe  Pro Asp Ser 
    2120                 2125                 2130             


Ala Tyr  Lys Thr Ala Gln Ala  Val Lys Asp Phe Asn  Arg Glu Lys 
    2135                 2140                 2145             


Leu Pro  Leu Met Ile Phe Ala  Asn Trp Arg Gly Phe  Ser Gly Gly 
    2150                 2155                 2160             


Met Lys  Asp Met Tyr Asp Gln  Val Leu Lys Phe Gly  Ala Tyr Ile 
    2165                 2170                 2175             


Val Asp  Gly Leu Arg Gln Tyr  Lys Gln Pro Ile Leu  Ile Tyr Ile 
    2180                 2185                 2190             


Pro Pro  Tyr Ala Glu Leu Arg  Gly Gly Ser Trp Val  Val Ile Asp 
    2195                 2200                 2205             


Ala Thr  Ile Asn Pro Leu Cys  Ile Glu Met Tyr Ala  Asp Lys Glu 
    2210                 2215                 2220             


Ser Arg  Gly Gly Val Leu Glu  Pro Glu Gly Thr Val  Glu Ile Lys 
    2225                 2230                 2235             


Phe Arg  Lys Lys Asp Leu Ile  Lys Ser Met Arg Arg  Ile Asp Pro 
    2240                 2245                 2250             


Ala Tyr  Lys Lys Leu Met Glu  Gln Leu Gly Glu Pro  Asp Leu Ser 
    2255                 2260                 2265             


Asp Lys  Asp Arg Lys Asp Leu  Glu Gly Arg Leu Lys  Ala Arg Glu 
    2270                 2275                 2280             


Asp Leu  Leu Leu Pro Ile Tyr  His Gln Val Ala Val  Gln Phe Ala 
    2285                 2290                 2295             


Asp Phe  His Asp Thr Pro Gly  Arg Met Leu Glu Lys  Gly Val Ile 
    2300                 2305                 2310             


Ser Asp  Ile Leu Glu Trp Lys  Thr Ala Arg Thr Phe  Leu Tyr Trp 
    2315                 2320                 2325             


Arg Leu  Arg Arg Leu Leu Leu  Glu Asp Gln Val Lys  Gln Glu Ile 
    2330                 2335                 2340             


Leu Gln  Ala Ser Gly Glu Leu  Ser His Val His Ile  Gln Ser Met 
    2345                 2350                 2355             


Leu Arg  Arg Trp Phe Val Glu  Thr Glu Gly Ala Val  Lys Ala Tyr 
    2360                 2365                 2370             


Leu Trp  Asp Asn Asn Gln Val  Val Val Gln Trp Leu  Glu Gln His 
    2375                 2380                 2385             


Trp Gln  Ala Gly Asp Gly Pro  Arg Ser Thr Ile Arg  Glu Asn Ile 
    2390                 2395                 2400             


Thr Tyr  Leu Lys His Asp Ser  Val Leu Lys Thr Ile  Arg Gly Leu 
    2405                 2410                 2415             


Val Glu  Glu Asn Pro Glu Val  Ala Val Asp Cys Val  Ile Tyr Leu 
    2420                 2425                 2430             


Ser Gln  His Ile Ser Pro Ala  Glu Arg Ala Gln Val  Val His Leu 
    2435                 2440                 2445             


Leu Ser  Thr Met Asp Ser Pro  Ala Ser Thr 
    2450                 2455             


<210>  99
<211>  859
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  99

Xaa Met Thr Val Pro Ile Ser Ile Thr Asn Pro Asp Leu Leu Arg His 
1               5                   10                  15      


Ser Thr Glu Leu Phe Met Asp Ser Gly Phe Ser Pro Leu Cys Gln Arg 
            20                  25                  30          


Met Gly Ala Met Val Ala Phe Arg Arg Phe Glu Asp Phe Thr Arg Asn 
        35                  40                  45              


Phe Asp Glu Val Ile Ser Cys Phe Ala Asn Val Pro Lys Asp Thr Pro 
    50                  55                  60                  


Leu Phe Ser Glu Ala Arg Thr Ser Leu Tyr Ser Glu Asp Asp Cys Lys 
65                  70                  75                  80  


Ser Leu Arg Glu Glu Pro Ile His Ile Leu Asn Val Ser Ile Gln Cys 
                85                  90                  95      


Ala Asp His Leu Glu Asp Glu Ala Leu Val Pro Ile Leu Arg Thr Phe 
            100                 105                 110         


Val Gln Ser Lys Lys Asn Ile Leu Val Asp Tyr Gly Leu Arg Arg Ile 
        115                 120                 125             


Thr Phe Leu Ile Ala Gln Glu Lys Glu Phe Pro Lys Phe Phe Thr Phe 
    130                 135                 140                 


Arg Ala Arg Asp Glu Phe Ala Glu Asp Arg Ile Tyr Arg His Leu Glu 
145                 150                 155                 160 


Pro Ala Leu Ala Phe Gln Leu Glu Leu Asn Arg Met Arg Asn Phe Asp 
                165                 170                 175     


Leu Thr Ala Val Pro Cys Ala Asn His Lys Met His Leu Tyr Leu Gly 
            180                 185                 190         


Ala Ala Lys Val Lys Glu Gly Val Glu Val Thr Asp His Arg Phe Phe 
        195                 200                 205             


Ile Arg Ala Ile Ile Arg His Ser Asp Leu Ile Thr Lys Glu Ala Ser 
    210                 215                 220                 


Phe Glu Tyr Leu Gln Asn Glu Gly Glu Arg Leu Leu Leu Glu Ala Met 
225                 230                 235                 240 


Asp Glu Leu Glu Val Ala Phe Asn Asn Thr Ser Val Arg Thr Asp Cys 
                245                 250                 255     


Asn His Ile Phe Leu Asn Phe Val Pro Thr Val Ile Met Asp Pro Phe 
            260                 265                 270         


Lys Ile Glu Glu Ser Val Arg Tyr Met Val Met Arg Tyr Gly Ser Arg 
        275                 280                 285             


Leu Trp Lys Leu Arg Val Leu Gln Ala Glu Val Lys Ile Asn Ile Arg 
    290                 295                 300                 


Gln Thr Thr Thr Gly Ser Ala Val Pro Ile Arg Leu Phe Ile Thr Asn 
305                 310                 315                 320 


Glu Ser Gly Tyr Tyr Leu Asp Ile Ser Leu Tyr Lys Glu Val Thr Asp 
                325                 330                 335     


Ser Arg Ser Gly Asn Ile Met Phe His Ser Phe Gly Asn Lys Gln Gly 
            340                 345                 350         


Pro Gln His Gly Met Leu Ile Asn Thr Pro Tyr Val Thr Lys Asp Leu 
        355                 360                 365             


Leu Gln Ala Lys Arg Phe Gln Ala Gln Thr Leu Gly Thr Thr Tyr Ile 
    370                 375                 380                 


Tyr Asp Phe Pro Glu Met Phe Arg Gln Ala Leu Phe Lys Leu Trp Gly 
385                 390                 395                 400 


Ser Pro Asp Lys Tyr Pro Lys Asp Ile Leu Thr Tyr Thr Glu Leu Val 
                405                 410                 415     


Leu Asp Ser Gln Gly Gln Leu Val Glu Met Asn Arg Leu Pro Gly Gly 
            420                 425                 430         


Asn Glu Val Gly Met Val Ala Phe Lys Met Arg Phe Lys Thr Gln Glu 
        435                 440                 445             


Tyr Pro Glu Gly Arg Asp Val Ile Val Ile Gly Asn Asp Ile Thr Phe 
    450                 455                 460                 


Arg Ile Gly Ser Phe Gly Pro Gly Glu Asp Leu Leu Tyr Leu Arg Ala 
465                 470                 475                 480 


Ser Glu Met Ala Arg Ala Glu Gly Ile Pro Lys Ile Tyr Val Ala Ala 
                485                 490                 495     


Asn Ser Gly Ala Arg Ile Gly Met Ala Glu Glu Ile Lys His Met Phe 
            500                 505                 510         


His Val Ala Trp Val Asp Pro Glu Asp Pro His Lys Gly Phe Lys Tyr 
        515                 520                 525             


Leu Tyr Leu Thr Pro Gln Asp Tyr Thr Arg Ile Ser Ser Leu Asn Ser 
    530                 535                 540                 


Val His Cys Lys His Ile Glu Glu Gly Gly Glu Ser Arg Tyr Met Ile 
545                 550                 555                 560 


Thr Asp Ile Ile Gly Lys Asp Asp Gly Leu Gly Val Glu Asn Leu Arg 
                565                 570                 575     


Gly Ser Gly Met Ile Ala Gly Glu Ser Ser Leu Ala Tyr Glu Glu Ile 
            580                 585                 590         


Val Thr Ile Ser Leu Val Thr Cys Arg Ala Ile Gly Ile Gly Ala Tyr 
        595                 600                 605             


Leu Val Arg Leu Gly Gln Arg Val Ile Gln Val Glu Asn Ser His Ile 
    610                 615                 620                 


Ile Leu Thr Gly Ala Ser Ala Leu Asn Lys Val Leu Gly Arg Glu Val 
625                 630                 635                 640 


Tyr Thr Ser Asn Asn Gln Leu Gly Gly Val Gln Ile Met His Tyr Asn 
                645                 650                 655     


Gly Val Ser His Ile Thr Val Pro Asp Asp Phe Glu Gly Val Tyr Thr 
            660                 665                 670         


Ile Leu Glu Trp Leu Ser Tyr Met Pro Lys Asp Asn His Ser Pro Val 
        675                 680                 685             


Pro Ile Ile Thr Pro Thr Asp Pro Ile Asp Arg Glu Ile Glu Phe Leu 
    690                 695                 700                 


Pro Ser Arg Ala Pro Tyr Asp Pro Arg Trp Met Leu Ala Gly Arg Pro 
705                 710                 715                 720 


His Pro Thr Leu Lys Gly Thr Trp Gln Ser Gly Phe Phe Asp His Gly 
                725                 730                 735     


Ser Phe Lys Glu Ile Met Ala Pro Trp Ala Gln Thr Val Val Thr Gly 
            740                 745                 750         


Arg Ala Arg Leu Gly Gly Ile Pro Val Gly Val Ile Ala Val Glu Thr 
        755                 760                 765             


Arg Thr Val Glu Val Ala Val Pro Ala Asp Pro Ala Asn Leu Asp Ser 
    770                 775                 780                 


Glu Ala Lys Ile Ile Gln Gln Ala Gly Gln Val Trp Phe Pro Asp Ser 
785                 790                 795                 800 


Ala Tyr Lys Thr Ala Gln Ala Val Lys Asp Phe Asn Arg Glu Lys Leu 
                805                 810                 815     


Pro Leu Met Ile Phe Ala Asn Trp Arg Gly Phe Ser Gly Gly Met Lys 
            820                 825                 830         


Gly Cys Leu Gly Thr Trp Arg Asp Val Ser Trp Trp Lys Ile Arg Ala 
        835                 840                 845             


Met Leu Pro Met His Ile Gly Glu Gly Ser Val 
    850                 855                 


<210>  100
<211>  112
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  100

Xaa Val Glu Met Asn Arg Leu Pro Gly Gly Asn Glu Val Gly Met Val 
1               5                   10                  15      


Ala Phe Lys Met Arg Phe Lys Thr Gln Glu Tyr Pro Glu Gly Arg Asp 
            20                  25                  30          


Val Ile Val Ile Gly Asn Asp Ile Thr Phe Arg Ile Gly Ser Phe Gly 
        35                  40                  45              


Pro Gly Glu Asp Leu Leu Tyr Leu Arg Ala Ser Glu Met Ala Arg Ala 
    50                  55                  60                  


Glu Gly Ile Pro Lys Ile Tyr Val Ala Ala Asn Ser Gly Ala Arg Ile 
65                  70                  75                  80  


Gly Met Ala Glu Glu Ile Lys His Met Phe His Val Ala Trp Val Asp 
                85                  90                  95      


Pro Glu Asp Pro His Lys Ile His Asp His Gly Tyr His Arg Glu Gly 
            100                 105                 110         


<210>  101
<211>  2431
<212>  PRT
<213>  Homo Sapiens

<400>  101

Met Thr Thr Leu Leu Trp Val Phe Val Thr Leu Arg Val Ile Thr Ala 
1               5                   10                  15      


Ala Val Thr Val Glu Thr Ser Asp His Asp Asn Ser Leu Ser Val Ser 
            20                  25                  30          


Ile Pro Gln Pro Ser Pro Leu Arg Val Leu Leu Gly Thr Ser Leu Thr 
        35                  40                  45              


Ile Pro Cys Tyr Phe Ile Asp Pro Met His Pro Val Thr Thr Ala Pro 
    50                  55                  60                  


Ser Thr Ala Pro Leu Ala Pro Arg Ile Lys Trp Ser Arg Val Ser Lys 
65                  70                  75                  80  


Glu Lys Glu Val Val Leu Leu Val Ala Thr Glu Gly Arg Val Arg Val 
                85                  90                  95      


Asn Ser Ala Tyr Gln Asp Lys Val Ser Leu Pro Asn Tyr Pro Ala Ile 
            100                 105                 110         


Pro Ser Asp Ala Thr Leu Glu Val Gln Ser Leu Arg Ser Asn Asp Ser 
        115                 120                 125             


Gly Val Tyr Arg Cys Glu Val Met His Gly Ile Glu Asp Ser Glu Ala 
    130                 135                 140                 


Thr Leu Glu Val Val Val Lys Gly Ile Val Phe His Tyr Arg Ala Ile 
145                 150                 155                 160 


Ser Thr Arg Tyr Thr Leu Asp Phe Asp Arg Ala Gln Arg Ala Cys Leu 
                165                 170                 175     


Gln Asn Ser Ala Ile Ile Ala Thr Pro Glu Gln Leu Gln Ala Ala Tyr 
            180                 185                 190         


Glu Asp Gly Phe His Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr 
        195                 200                 205             


Val Arg Tyr Pro Ile His Thr Pro Arg Glu Gly Cys Tyr Gly Asp Lys 
    210                 215                 220                 


Asp Glu Phe Pro Gly Val Arg Thr Tyr Gly Ile Arg Asp Thr Asn Glu 
225                 230                 235                 240 


Thr Tyr Asp Val Tyr Cys Phe Ala Glu Glu Met Glu Gly Glu Val Phe 
                245                 250                 255     


Tyr Ala Thr Ser Pro Glu Lys Phe Thr Phe Gln Glu Ala Ala Asn Glu 
            260                 265                 270         


Cys Arg Arg Leu Gly Ala Arg Leu Ala Thr Thr Gly Gln Leu Tyr Leu 
        275                 280                 285             


Ala Trp Gln Ala Gly Met Asp Met Cys Ser Ala Gly Trp Leu Ala Asp 
    290                 295                 300                 


Arg Ser Val Arg Tyr Pro Ile Ser Lys Ala Arg Pro Asn Cys Gly Gly 
305                 310                 315                 320 


Asn Leu Leu Gly Val Arg Thr Val Tyr Val His Ala Asn Gln Thr Gly 
                325                 330                 335     


Tyr Pro Asp Pro Ser Ser Arg Tyr Asp Ala Ile Cys Tyr Thr Gly Glu 
            340                 345                 350         


Asp Phe Val Asp Ile Pro Glu Asn Phe Phe Gly Val Gly Gly Glu Glu 
        355                 360                 365             


Asp Ile Thr Val Gln Thr Val Thr Trp Pro Asp Met Glu Leu Pro Leu 
    370                 375                 380                 


Pro Arg Asn Ile Thr Glu Gly Glu Ala Arg Gly Ser Val Ile Leu Thr 
385                 390                 395                 400 


Val Lys Pro Ile Phe Glu Val Ser Pro Ser Pro Leu Glu Pro Glu Glu 
                405                 410                 415     


Pro Phe Thr Phe Ala Pro Glu Ile Gly Ala Thr Ala Phe Ala Glu Val 
            420                 425                 430         


Glu Asn Glu Thr Gly Glu Ala Thr Arg Pro Trp Gly Phe Pro Thr Pro 
        435                 440                 445             


Gly Leu Gly Pro Ala Thr Ala Phe Thr Ser Glu Asp Leu Val Val Gln 
    450                 455                 460                 


Val Thr Ala Val Pro Gly Gln Pro His Leu Pro Gly Gly Val Val Phe 
465                 470                 475                 480 


His Tyr Arg Pro Gly Pro Thr Arg Tyr Ser Leu Thr Phe Glu Glu Ala 
                485                 490                 495     


Gln Gln Ala Cys Leu Arg Thr Gly Ala Val Ile Ala Ser Pro Glu Gln 
            500                 505                 510         


Leu Gln Ala Ala Tyr Glu Ala Gly Tyr Glu Gln Cys Asp Ala Gly Trp 
        515                 520                 525             


Leu Arg Asp Gln Thr Val Arg Tyr Pro Ile Val Ser Pro Arg Thr Pro 
    530                 535                 540                 


Cys Val Gly Asp Lys Asp Ser Ser Pro Gly Val Arg Thr Tyr Gly Val 
545                 550                 555                 560 


Arg Pro Ser Thr Glu Thr Tyr Asp Val Tyr Cys Phe Val Asp Arg Leu 
                565                 570                 575     


Glu Gly Glu Val Phe Phe Ala Thr Arg Leu Glu Gln Phe Thr Phe Gln 
            580                 585                 590         


Glu Ala Leu Glu Phe Cys Glu Ser His Asn Ala Thr Leu Ala Thr Thr 
        595                 600                 605             


Gly Gln Leu Tyr Ala Ala Trp Ser Arg Gly Leu Asp Lys Cys Tyr Ala 
    610                 615                 620                 


Gly Trp Leu Ala Asp Gly Ser Leu Arg Tyr Pro Ile Val Thr Pro Arg 
625                 630                 635                 640 


Pro Ala Cys Gly Gly Asp Lys Pro Gly Val Arg Thr Val Tyr Leu Tyr 
                645                 650                 655     


Pro Asn Gln Thr Gly Leu Pro Asp Pro Leu Ser Arg His His Ala Phe 
            660                 665                 670         


Cys Phe Arg Gly Ile Ser Ala Val Pro Ser Pro Gly Glu Glu Glu Gly 
        675                 680                 685             


Gly Thr Pro Thr Ser Pro Ser Gly Val Glu Glu Trp Ile Val Thr Gln 
    690                 695                 700                 


Val Val Pro Gly Val Ala Ala Val Pro Val Glu Glu Glu Thr Thr Ala 
705                 710                 715                 720 


Val Pro Ser Gly Glu Thr Thr Ala Ile Leu Glu Phe Thr Thr Glu Pro 
                725                 730                 735     


Glu Asn Gln Thr Glu Trp Glu Pro Ala Tyr Thr Pro Val Gly Thr Ser 
            740                 745                 750         


Pro Leu Pro Gly Ile Leu Pro Thr Trp Pro Pro Thr Gly Ala Ala Thr 
        755                 760                 765             


Glu Glu Ser Thr Glu Gly Pro Ser Ala Thr Glu Val Pro Ser Ala Ser 
    770                 775                 780                 


Glu Glu Pro Ser Pro Ser Glu Val Pro Phe Pro Ser Glu Glu Pro Ser 
785                 790                 795                 800 


Pro Ser Glu Glu Pro Phe Pro Ser Val Arg Pro Phe Pro Ser Val Glu 
                805                 810                 815     


Leu Phe Pro Ser Glu Glu Pro Phe Pro Ser Lys Glu Pro Ser Pro Ser 
            820                 825                 830         


Glu Glu Pro Ser Ala Ser Glu Glu Pro Tyr Thr Pro Ser Pro Pro Val 
        835                 840                 845             


Pro Ser Trp Thr Glu Leu Pro Ser Ser Gly Glu Glu Ser Gly Ala Pro 
    850                 855                 860                 


Asp Val Ser Gly Asp Phe Thr Gly Ser Gly Asp Val Ser Gly His Leu 
865                 870                 875                 880 


Asp Phe Ser Gly Gln Leu Ser Gly Asp Arg Ala Ser Gly Leu Pro Ser 
                885                 890                 895     


Gly Asp Leu Asp Ser Ser Gly Leu Thr Ser Thr Val Gly Ser Gly Leu 
            900                 905                 910         


Pro Val Glu Ser Gly Leu Pro Ser Gly Asp Glu Glu Arg Ile Glu Trp 
        915                 920                 925             


Pro Ser Thr Pro Thr Val Gly Glu Leu Pro Ser Gly Ala Glu Ile Leu 
    930                 935                 940                 


Glu Gly Ser Ala Ser Gly Val Gly Asp Leu Ser Gly Leu Pro Ser Gly 
945                 950                 955                 960 


Glu Val Leu Glu Thr Ser Ala Ser Gly Val Gly Asp Leu Ser Gly Leu 
                965                 970                 975     


Pro Ser Gly Glu Val Leu Glu Thr Thr Ala Pro Gly Val Glu Asp Ile 
            980                 985                 990         


Ser Gly Leu Pro Ser Gly Glu Val  Leu Glu Thr Thr Ala  Pro Gly Val 
        995                 1000                 1005             


Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu Val Leu  Glu Thr Thr 
    1010                 1015                 1020             


Ala Pro  Gly Val Glu Asp Ile  Ser Gly Leu Pro Ser  Gly Glu Val 
    1025                 1030                 1035             


Leu Glu  Thr Thr Ala Pro Gly  Val Glu Asp Ile Ser  Gly Leu Pro 
    1040                 1045                 1050             


Ser Gly  Glu Val Leu Glu Thr  Thr Ala Pro Gly Val  Glu Asp Ile 
    1055                 1060                 1065             


Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu Thr Thr  Ala Pro Gly 
    1070                 1075                 1080             


Val Glu  Asp Ile Ser Gly Leu  Pro Ser Gly Glu Val  Leu Glu Thr 
    1085                 1090                 1095             


Ala Ala  Pro Gly Val Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu 
    1100                 1105                 1110             


Val Leu  Glu Thr Ala Ala Pro  Gly Val Glu Asp Ile  Ser Gly Leu 
    1115                 1120                 1125             


Pro Ser  Gly Glu Val Leu Glu  Thr Ala Ala Pro Gly  Val Glu Asp 
    1130                 1135                 1140             


Ile Ser  Gly Leu Pro Ser Gly  Glu Val Leu Glu Thr  Ala Ala Pro 
    1145                 1150                 1155             


Gly Val  Glu Asp Ile Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu 
    1160                 1165                 1170             


Thr Ala  Ala Pro Gly Val Glu  Asp Ile Ser Gly Leu  Pro Ser Gly 
    1175                 1180                 1185             


Glu Val  Leu Glu Thr Ala Ala  Pro Gly Val Glu Asp  Ile Ser Gly 
    1190                 1195                 1200             


Leu Pro  Ser Gly Glu Val Leu  Glu Thr Ala Ala Pro  Gly Val Glu 
    1205                 1210                 1215             


Asp Ile  Ser Gly Leu Pro Ser  Gly Glu Val Leu Glu  Thr Ala Ala 
    1220                 1225                 1230             


Pro Gly  Val Glu Asp Ile Ser  Gly Leu Pro Ser Gly  Glu Val Leu 
    1235                 1240                 1245             


Glu Thr  Ala Ala Pro Gly Val  Glu Asp Ile Ser Gly  Leu Pro Ser 
    1250                 1255                 1260             


Gly Glu  Val Leu Glu Thr Ala  Ala Pro Gly Val Glu  Asp Ile Ser 
    1265                 1270                 1275             


Gly Leu  Pro Ser Gly Glu Val  Leu Glu Thr Ala Ala  Pro Gly Val 
    1280                 1285                 1290             


Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu Val Leu  Glu Thr Ala 
    1295                 1300                 1305             


Ala Pro  Gly Val Glu Asp Ile  Ser Gly Leu Pro Ser  Gly Glu Val 
    1310                 1315                 1320             


Leu Glu  Thr Ala Ala Pro Gly  Val Glu Asp Ile Ser  Gly Leu Pro 
    1325                 1330                 1335             


Ser Gly  Glu Val Leu Glu Thr  Ala Ala Pro Gly Val  Glu Asp Ile 
    1340                 1345                 1350             


Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu Thr Ala  Ala Pro Gly 
    1355                 1360                 1365             


Val Glu  Asp Ile Ser Gly Leu  Pro Ser Gly Glu Val  Leu Glu Thr 
    1370                 1375                 1380             


Ala Ala  Pro Gly Val Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu 
    1385                 1390                 1395             


Val Leu  Glu Thr Thr Ala Pro  Gly Val Glu Glu Ile  Ser Gly Leu 
    1400                 1405                 1410             


Pro Ser  Gly Glu Val Leu Glu  Thr Thr Ala Pro Gly  Val Asp Glu 
    1415                 1420                 1425             


Ile Ser  Gly Leu Pro Ser Gly  Glu Val Leu Glu Thr  Thr Ala Pro 
    1430                 1435                 1440             


Gly Val  Glu Glu Ile Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu 
    1445                 1450                 1455             


Thr Ser  Thr Ser Ala Val Gly  Asp Leu Ser Gly Leu  Pro Ser Gly 
    1460                 1465                 1470             


Gly Glu  Val Leu Glu Ile Ser  Val Ser Gly Val Glu  Asp Ile Ser 
    1475                 1480                 1485             


Gly Leu  Pro Ser Gly Glu Val  Val Glu Thr Ser Ala  Ser Gly Ile 
    1490                 1495                 1500             


Glu Asp  Val Ser Glu Leu Pro  Ser Gly Glu Gly Leu  Glu Thr Ser 
    1505                 1510                 1515             


Ala Ser  Gly Val Glu Asp Leu  Ser Arg Leu Pro Ser  Gly Glu Glu 
    1520                 1525                 1530             


Val Leu  Glu Ile Ser Ala Ser  Gly Phe Gly Asp Leu  Ser Gly Leu 
    1535                 1540                 1545             


Pro Ser  Gly Gly Glu Gly Leu  Glu Thr Ser Ala Ser  Glu Val Gly 
    1550                 1555                 1560             


Thr Asp  Leu Ser Gly Leu Pro  Ser Gly Arg Glu Gly  Leu Glu Thr 
    1565                 1570                 1575             


Ser Ala  Ser Gly Ala Glu Asp  Leu Ser Gly Leu Pro  Ser Gly Lys 
    1580                 1585                 1590             


Glu Asp  Leu Val Gly Ser Ala  Ser Gly Asp Leu Asp  Leu Gly Lys 
    1595                 1600                 1605             


Leu Pro  Ser Gly Thr Leu Gly  Ser Gly Gln Ala Pro  Glu Thr Ser 
    1610                 1615                 1620             


Gly Leu  Pro Ser Gly Phe Ser  Gly Glu Tyr Ser Gly  Val Asp Leu 
    1625                 1630                 1635             


Gly Ser  Gly Pro Pro Ser Gly  Leu Pro Asp Phe Ser  Gly Leu Pro 
    1640                 1645                 1650             


Ser Gly  Phe Pro Thr Val Ser  Leu Val Asp Ser Thr  Leu Val Glu 
    1655                 1660                 1665             


Val Val  Thr Ala Ser Thr Ala  Ser Glu Leu Glu Gly  Arg Gly Thr 
    1670                 1675                 1680             


Ile Gly  Ile Ser Gly Ala Gly  Glu Ile Ser Gly Leu  Pro Ser Ser 
    1685                 1690                 1695             


Glu Leu  Asp Ile Ser Gly Arg  Ala Ser Gly Leu Pro  Ser Gly Thr 
    1700                 1705                 1710             


Glu Leu  Ser Gly Gln Ala Ser  Gly Ser Pro Asp Val  Ser Gly Glu 
    1715                 1720                 1725             


Ile Pro  Gly Leu Phe Gly Val  Ser Gly Gln Pro Ser  Gly Phe Pro 
    1730                 1735                 1740             


Asp Thr  Ser Gly Glu Thr Ser  Gly Val Thr Glu Leu  Ser Gly Leu 
    1745                 1750                 1755             


Ser Ser  Gly Gln Pro Gly Ile  Ser Gly Glu Ala Ser  Gly Val Leu 
    1760                 1765                 1770             


Tyr Gly  Thr Ser Gln Pro Phe  Gly Ile Thr Asp Leu  Ser Gly Glu 
    1775                 1780                 1785             


Thr Ser  Gly Val Pro Asp Leu  Ser Gly Gln Pro Ser  Gly Leu Pro 
    1790                 1795                 1800             


Gly Phe  Ser Gly Ala Thr Ser  Gly Val Pro Asp Leu  Val Ser Gly 
    1805                 1810                 1815             


Thr Thr  Ser Gly Ser Gly Glu  Ser Ser Gly Ile Thr  Phe Val Asp 
    1820                 1825                 1830             


Thr Ser  Leu Val Glu Val Ala  Pro Thr Thr Phe Lys  Glu Glu Glu 
    1835                 1840                 1845             


Gly Leu  Gly Ser Val Glu Leu  Ser Gly Leu Pro Ser  Gly Glu Ala 
    1850                 1855                 1860             


Asp Leu  Ser Gly Lys Ser Gly  Met Val Asp Val Ser  Gly Gln Phe 
    1865                 1870                 1875             


Ser Gly  Thr Val Asp Ser Ser  Gly Phe Thr Ser Gln  Thr Pro Glu 
    1880                 1885                 1890             


Phe Ser  Gly Leu Pro Ser Gly  Ile Ala Glu Val Ser  Gly Glu Ser 
    1895                 1900                 1905             


Ser Arg  Ala Glu Ile Gly Ser  Ser Leu Pro Ser Gly  Ala Tyr Tyr 
    1910                 1915                 1920             


Gly Ser  Gly Thr Pro Ser Ser  Phe Pro Thr Val Ser  Leu Val Asp 
    1925                 1930                 1935             


Arg Thr  Leu Val Glu Ser Val  Thr Gln Ala Pro Thr  Ala Gln Glu 
    1940                 1945                 1950             


Ala Gly  Glu Gly Pro Ser Gly  Ile Leu Glu Leu Ser  Gly Ala His 
    1955                 1960                 1965             


Ser Gly  Ala Pro Asp Met Ser  Gly Glu His Ser Gly  Phe Leu Asp 
    1970                 1975                 1980             


Leu Ser  Gly Leu Gln Ser Gly  Leu Ile Glu Pro Ser  Gly Glu Pro 
    1985                 1990                 1995             


Pro Gly  Thr Pro Tyr Phe Ser  Gly Asp Phe Ala Ser  Thr Thr Asn 
    2000                 2005                 2010             


Val Ser  Gly Glu Ser Ser Val  Ala Met Gly Thr Ser  Gly Glu Ala 
    2015                 2020                 2025             


Ser Gly  Leu Pro Glu Val Thr  Leu Ile Thr Ser Glu  Phe Val Glu 
    2030                 2035                 2040             


Gly Val  Thr Glu Pro Thr Ile  Ser Gln Glu Leu Gly  Gln Arg Pro 
    2045                 2050                 2055             


Pro Val  Thr His Thr Pro Gln  Leu Phe Glu Ser Ser  Gly Lys Val 
    2060                 2065                 2070             


Ser Thr  Ala Gly Asp Ile Ser  Gly Ala Thr Pro Val  Leu Pro Gly 
    2075                 2080                 2085             


Ser Gly  Val Glu Val Ser Ser  Val Pro Glu Ser Ser  Ser Glu Thr 
    2090                 2095                 2100             


Ser Ala  Tyr Pro Glu Ala Gly  Phe Gly Ala Ser Ala  Ala Pro Glu 
    2105                 2110                 2115             


Ala Ser  Arg Glu Asp Ser Gly  Ser Pro Asp Leu Ser  Glu Thr Thr 
    2120                 2125                 2130             


Ser Ala  Phe His Glu Ala Asn  Leu Glu Arg Ser Ser  Gly Leu Gly 
    2135                 2140                 2145             


Val Ser  Gly Ser Thr Leu Thr  Phe Gln Glu Gly Glu  Ala Ser Ala 
    2150                 2155                 2160             


Ala Pro  Glu Val Ser Gly Glu  Ser Thr Thr Thr Ser  Asp Val Gly 
    2165                 2170                 2175             


Thr Glu  Ala Pro Gly Leu Pro  Ser Ala Thr Pro Thr  Ala Ser Gly 
    2180                 2185                 2190             


Asp Arg  Thr Glu Ile Ser Gly  Asp Leu Ser Gly His  Thr Ser Gln 
    2195                 2200                 2205             


Leu Gly  Val Val Ile Ser Thr  Ser Ile Pro Glu Ser  Glu Trp Thr 
    2210                 2215                 2220             


Gln Gln  Thr Gln Arg Pro Ala  Glu Thr His Leu Glu  Ile Glu Ser 
    2225                 2230                 2235             


Ser Ser  Leu Leu Tyr Ser Gly  Glu Glu Thr His Thr  Val Glu Thr 
    2240                 2245                 2250             


Ala Thr  Ser Pro Thr Asp Ala  Ser Ile Pro Ala Ser  Pro Glu Trp 
    2255                 2260                 2265             


Lys Arg  Glu Ser Glu Ser Thr  Ala Ala Asp Gln Glu  Val Cys Glu 
    2270                 2275                 2280             


Glu Gly  Trp Asn Lys Tyr Gln  Gly His Cys Tyr Arg  His Phe Pro 
    2285                 2290                 2295             


Asp Arg  Glu Thr Trp Val Asp  Ala Glu Arg Arg Cys  Arg Glu Gln 
    2300                 2305                 2310             


Gln Ser  His Leu Ser Ser Ile  Val Thr Pro Glu Glu  Gln Glu Phe 
    2315                 2320                 2325             


Val Asn  Asn Asn Ala Gln Asp  Tyr Gln Trp Ile Gly  Leu Asn Asp 
    2330                 2335                 2340             


Arg Thr  Ile Glu Gly Asp Phe  Arg Trp Ser Asp Gly  His Pro Met 
    2345                 2350                 2355             


Gln Phe  Glu Asn Trp Arg Pro  Asn Gln Pro Asp Asn  Phe Phe Ala 
    2360                 2365                 2370             


Ala Gly  Glu Asp Cys Val Val  Met Ile Trp His Glu  Lys Gly Glu 
    2375                 2380                 2385             


Trp Asn  Asp Val Pro Cys Asn  Tyr His Leu Pro Phe  Thr Cys Lys 
    2390                 2395                 2400             


Lys Gly  Thr Ala Thr Thr Tyr  Lys Arg Arg Leu Gln  Lys Arg Ser 
    2405                 2410                 2415             


Ser Arg  His Pro Arg Arg Ser  Arg Pro Ser Thr Ala  His 
    2420                 2425                 2430     


<210>  102
<211>  2530
<212>  PRT
<213>  Homo Sapiens

<400>  102

Met Thr Thr Leu Leu Trp Val Phe Val Thr Leu Arg Val Ile Thr Ala 
1               5                   10                  15      


Ala Val Thr Val Glu Thr Ser Asp His Asp Asn Ser Leu Ser Val Ser 
            20                  25                  30          


Ile Pro Gln Pro Ser Pro Leu Arg Val Leu Leu Gly Thr Ser Leu Thr 
        35                  40                  45              


Ile Pro Cys Tyr Phe Ile Asp Pro Met His Pro Val Thr Thr Ala Pro 
    50                  55                  60                  


Ser Thr Ala Pro Leu Ala Pro Arg Ile Lys Trp Ser Arg Val Ser Lys 
65                  70                  75                  80  


Glu Lys Glu Val Val Leu Leu Val Ala Thr Glu Gly Arg Val Arg Val 
                85                  90                  95      


Asn Ser Ala Tyr Gln Asp Lys Val Ser Leu Pro Asn Tyr Pro Ala Ile 
            100                 105                 110         


Pro Ser Asp Ala Thr Leu Glu Val Gln Ser Leu Arg Ser Asn Asp Ser 
        115                 120                 125             


Gly Val Tyr Arg Cys Glu Val Met His Gly Ile Glu Asp Ser Glu Ala 
    130                 135                 140                 


Thr Leu Glu Val Val Val Lys Gly Ile Val Phe His Tyr Arg Ala Ile 
145                 150                 155                 160 


Ser Thr Arg Tyr Thr Leu Asp Phe Asp Arg Ala Gln Arg Ala Cys Leu 
                165                 170                 175     


Gln Asn Ser Ala Ile Ile Ala Thr Pro Glu Gln Leu Gln Ala Ala Tyr 
            180                 185                 190         


Glu Asp Gly Phe His Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr 
        195                 200                 205             


Val Arg Tyr Pro Ile His Thr Pro Arg Glu Gly Cys Tyr Gly Asp Lys 
    210                 215                 220                 


Asp Glu Phe Pro Gly Val Arg Thr Tyr Gly Ile Arg Asp Thr Asn Glu 
225                 230                 235                 240 


Thr Tyr Asp Val Tyr Cys Phe Ala Glu Glu Met Glu Gly Glu Val Phe 
                245                 250                 255     


Tyr Ala Thr Ser Pro Glu Lys Phe Thr Phe Gln Glu Ala Ala Asn Glu 
            260                 265                 270         


Cys Arg Arg Leu Gly Ala Arg Leu Ala Thr Thr Gly Gln Leu Tyr Leu 
        275                 280                 285             


Ala Trp Gln Ala Gly Met Asp Met Cys Ser Ala Gly Trp Leu Ala Asp 
    290                 295                 300                 


Arg Ser Val Arg Tyr Pro Ile Ser Lys Ala Arg Pro Asn Cys Gly Gly 
305                 310                 315                 320 


Asn Leu Leu Gly Val Arg Thr Val Tyr Val His Ala Asn Gln Thr Gly 
                325                 330                 335     


Tyr Pro Asp Pro Ser Ser Arg Tyr Asp Ala Ile Cys Tyr Thr Gly Glu 
            340                 345                 350         


Asp Phe Val Asp Ile Pro Glu Asn Phe Phe Gly Val Gly Gly Glu Glu 
        355                 360                 365             


Asp Ile Thr Val Gln Thr Val Thr Trp Pro Asp Met Glu Leu Pro Leu 
    370                 375                 380                 


Pro Arg Asn Ile Thr Glu Gly Glu Ala Arg Gly Ser Val Ile Leu Thr 
385                 390                 395                 400 


Val Lys Pro Ile Phe Glu Val Ser Pro Ser Pro Leu Glu Pro Glu Glu 
                405                 410                 415     


Pro Phe Thr Phe Ala Pro Glu Ile Gly Ala Thr Ala Phe Ala Glu Val 
            420                 425                 430         


Glu Asn Glu Thr Gly Glu Ala Thr Arg Pro Trp Gly Phe Pro Thr Pro 
        435                 440                 445             


Gly Leu Gly Pro Ala Thr Ala Phe Thr Ser Glu Asp Leu Val Val Gln 
    450                 455                 460                 


Val Thr Ala Val Pro Gly Gln Pro His Leu Pro Gly Gly Val Val Phe 
465                 470                 475                 480 


His Tyr Arg Pro Gly Pro Thr Arg Tyr Ser Leu Thr Phe Glu Glu Ala 
                485                 490                 495     


Gln Gln Ala Cys Leu Arg Thr Gly Ala Val Ile Ala Ser Pro Glu Gln 
            500                 505                 510         


Leu Gln Ala Ala Tyr Glu Ala Gly Tyr Glu Gln Cys Asp Ala Gly Trp 
        515                 520                 525             


Leu Arg Asp Gln Thr Val Arg Tyr Pro Ile Val Ser Pro Arg Thr Pro 
    530                 535                 540                 


Cys Val Gly Asp Lys Asp Ser Ser Pro Gly Val Arg Thr Tyr Gly Val 
545                 550                 555                 560 


Arg Pro Ser Thr Glu Thr Tyr Asp Val Tyr Cys Phe Val Asp Arg Leu 
                565                 570                 575     


Glu Gly Glu Val Phe Phe Ala Thr Arg Leu Glu Gln Phe Thr Phe Gln 
            580                 585                 590         


Glu Ala Leu Glu Phe Cys Glu Ser His Asn Ala Thr Leu Ala Thr Thr 
        595                 600                 605             


Gly Gln Leu Tyr Ala Ala Trp Ser Arg Gly Leu Asp Lys Cys Tyr Ala 
    610                 615                 620                 


Gly Trp Leu Ala Asp Gly Ser Leu Arg Tyr Pro Ile Val Thr Pro Arg 
625                 630                 635                 640 


Pro Ala Cys Gly Gly Asp Lys Pro Gly Val Arg Thr Val Tyr Leu Tyr 
                645                 650                 655     


Pro Asn Gln Thr Gly Leu Pro Asp Pro Leu Ser Arg His His Ala Phe 
            660                 665                 670         


Cys Phe Arg Gly Ile Ser Ala Val Pro Ser Pro Gly Glu Glu Glu Gly 
        675                 680                 685             


Gly Thr Pro Thr Ser Pro Ser Gly Val Glu Glu Trp Ile Val Thr Gln 
    690                 695                 700                 


Val Val Pro Gly Val Ala Ala Val Pro Val Glu Glu Glu Thr Thr Ala 
705                 710                 715                 720 


Val Pro Ser Gly Glu Thr Thr Ala Ile Leu Glu Phe Thr Thr Glu Pro 
                725                 730                 735     


Glu Asn Gln Thr Glu Trp Glu Pro Ala Tyr Thr Pro Val Gly Thr Ser 
            740                 745                 750         


Pro Leu Pro Gly Ile Leu Pro Thr Trp Pro Pro Thr Gly Ala Ala Thr 
        755                 760                 765             


Glu Glu Ser Thr Glu Gly Pro Ser Ala Thr Glu Val Pro Ser Ala Ser 
    770                 775                 780                 


Glu Glu Pro Ser Pro Ser Glu Val Pro Phe Pro Ser Glu Glu Pro Ser 
785                 790                 795                 800 


Pro Ser Glu Glu Pro Phe Pro Ser Val Arg Pro Phe Pro Ser Val Glu 
                805                 810                 815     


Leu Phe Pro Ser Glu Glu Pro Phe Pro Ser Lys Glu Pro Ser Pro Ser 
            820                 825                 830         


Glu Glu Pro Ser Ala Ser Glu Glu Pro Tyr Thr Pro Ser Pro Pro Val 
        835                 840                 845             


Pro Ser Trp Thr Glu Leu Pro Ser Ser Gly Glu Glu Ser Gly Ala Pro 
    850                 855                 860                 


Asp Val Ser Gly Asp Phe Thr Gly Ser Gly Asp Val Ser Gly His Leu 
865                 870                 875                 880 


Asp Phe Ser Gly Gln Leu Ser Gly Asp Arg Ala Ser Gly Leu Pro Ser 
                885                 890                 895     


Gly Asp Leu Asp Ser Ser Gly Leu Thr Ser Thr Val Gly Ser Gly Leu 
            900                 905                 910         


Pro Val Glu Ser Gly Leu Pro Ser Gly Asp Glu Glu Arg Ile Glu Trp 
        915                 920                 925             


Pro Ser Thr Pro Thr Val Gly Glu Leu Pro Ser Gly Ala Glu Ile Leu 
    930                 935                 940                 


Glu Gly Ser Ala Ser Gly Val Gly Asp Leu Ser Gly Leu Pro Ser Gly 
945                 950                 955                 960 


Glu Val Leu Glu Thr Ser Ala Ser Gly Val Gly Asp Leu Ser Gly Leu 
                965                 970                 975     


Pro Ser Gly Glu Val Leu Glu Thr Thr Ala Pro Gly Val Glu Asp Ile 
            980                 985                 990         


Ser Gly Leu Pro Ser Gly Glu Val  Leu Glu Thr Thr Ala  Pro Gly Val 
        995                 1000                 1005             


Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu Val Leu  Glu Thr Thr 
    1010                 1015                 1020             


Ala Pro  Gly Val Glu Asp Ile  Ser Gly Leu Pro Ser  Gly Glu Val 
    1025                 1030                 1035             


Leu Glu  Thr Thr Ala Pro Gly  Val Glu Asp Ile Ser  Gly Leu Pro 
    1040                 1045                 1050             


Ser Gly  Glu Val Leu Glu Thr  Thr Ala Pro Gly Val  Glu Asp Ile 
    1055                 1060                 1065             


Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu Thr Thr  Ala Pro Gly 
    1070                 1075                 1080             


Val Glu  Asp Ile Ser Gly Leu  Pro Ser Gly Glu Val  Leu Glu Thr 
    1085                 1090                 1095             


Ala Ala  Pro Gly Val Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu 
    1100                 1105                 1110             


Val Leu  Glu Thr Ala Ala Pro  Gly Val Glu Asp Ile  Ser Gly Leu 
    1115                 1120                 1125             


Pro Ser  Gly Glu Val Leu Glu  Thr Ala Ala Pro Gly  Val Glu Asp 
    1130                 1135                 1140             


Ile Ser  Gly Leu Pro Ser Gly  Glu Val Leu Glu Thr  Ala Ala Pro 
    1145                 1150                 1155             


Gly Val  Glu Asp Ile Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu 
    1160                 1165                 1170             


Thr Ala  Ala Pro Gly Val Glu  Asp Ile Ser Gly Leu  Pro Ser Gly 
    1175                 1180                 1185             


Glu Val  Leu Glu Thr Ala Ala  Pro Gly Val Glu Asp  Ile Ser Gly 
    1190                 1195                 1200             


Leu Pro  Ser Gly Glu Val Leu  Glu Thr Ala Ala Pro  Gly Val Glu 
    1205                 1210                 1215             


Asp Ile  Ser Gly Leu Pro Ser  Gly Glu Val Leu Glu  Thr Ala Ala 
    1220                 1225                 1230             


Pro Gly  Val Glu Asp Ile Ser  Gly Leu Pro Ser Gly  Glu Val Leu 
    1235                 1240                 1245             


Glu Thr  Ala Ala Pro Gly Val  Glu Asp Ile Ser Gly  Leu Pro Ser 
    1250                 1255                 1260             


Gly Glu  Val Leu Glu Thr Ala  Ala Pro Gly Val Glu  Asp Ile Ser 
    1265                 1270                 1275             


Gly Leu  Pro Ser Gly Glu Val  Leu Glu Thr Ala Ala  Pro Gly Val 
    1280                 1285                 1290             


Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu Val Leu  Glu Thr Ala 
    1295                 1300                 1305             


Ala Pro  Gly Val Glu Asp Ile  Ser Gly Leu Pro Ser  Gly Glu Val 
    1310                 1315                 1320             


Leu Glu  Thr Ala Ala Pro Gly  Val Glu Asp Ile Ser  Gly Leu Pro 
    1325                 1330                 1335             


Ser Gly  Glu Val Leu Glu Thr  Ala Ala Pro Gly Val  Glu Asp Ile 
    1340                 1345                 1350             


Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu Thr Ala  Ala Pro Gly 
    1355                 1360                 1365             


Val Glu  Asp Ile Ser Gly Leu  Pro Ser Gly Glu Val  Leu Glu Thr 
    1370                 1375                 1380             


Ala Ala  Pro Gly Val Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu 
    1385                 1390                 1395             


Val Leu  Glu Thr Thr Ala Pro  Gly Val Glu Glu Ile  Ser Gly Leu 
    1400                 1405                 1410             


Pro Ser  Gly Glu Val Leu Glu  Thr Thr Ala Pro Gly  Val Asp Glu 
    1415                 1420                 1425             


Ile Ser  Gly Leu Pro Ser Gly  Glu Val Leu Glu Thr  Thr Ala Pro 
    1430                 1435                 1440             


Gly Val  Glu Glu Ile Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu 
    1445                 1450                 1455             


Thr Ser  Thr Ser Ala Val Gly  Asp Leu Ser Gly Leu  Pro Ser Gly 
    1460                 1465                 1470             


Gly Glu  Val Leu Glu Ile Ser  Val Ser Gly Val Glu  Asp Ile Ser 
    1475                 1480                 1485             


Gly Leu  Pro Ser Gly Glu Val  Val Glu Thr Ser Ala  Ser Gly Ile 
    1490                 1495                 1500             


Glu Asp  Val Ser Glu Leu Pro  Ser Gly Glu Gly Leu  Glu Thr Ser 
    1505                 1510                 1515             


Ala Ser  Gly Val Glu Asp Leu  Ser Arg Leu Pro Ser  Gly Glu Glu 
    1520                 1525                 1530             


Val Leu  Glu Ile Ser Ala Ser  Gly Phe Gly Asp Leu  Ser Gly Leu 
    1535                 1540                 1545             


Pro Ser  Gly Gly Glu Gly Leu  Glu Thr Ser Ala Ser  Glu Val Gly 
    1550                 1555                 1560             


Thr Asp  Leu Ser Gly Leu Pro  Ser Gly Arg Glu Gly  Leu Glu Thr 
    1565                 1570                 1575             


Ser Ala  Ser Gly Ala Glu Asp  Leu Ser Gly Leu Pro  Ser Gly Lys 
    1580                 1585                 1590             


Glu Asp  Leu Val Gly Ser Ala  Ser Gly Asp Leu Asp  Leu Gly Lys 
    1595                 1600                 1605             


Leu Pro  Ser Gly Thr Leu Gly  Ser Gly Gln Ala Pro  Glu Thr Ser 
    1610                 1615                 1620             


Gly Leu  Pro Ser Gly Phe Ser  Gly Glu Tyr Ser Gly  Val Asp Leu 
    1625                 1630                 1635             


Gly Ser  Gly Pro Pro Ser Gly  Leu Pro Asp Phe Ser  Gly Leu Pro 
    1640                 1645                 1650             


Ser Gly  Phe Pro Thr Val Ser  Leu Val Asp Ser Thr  Leu Val Glu 
    1655                 1660                 1665             


Val Val  Thr Ala Ser Thr Ala  Ser Glu Leu Glu Gly  Arg Gly Thr 
    1670                 1675                 1680             


Ile Gly  Ile Ser Gly Ala Gly  Glu Ile Ser Gly Leu  Pro Ser Ser 
    1685                 1690                 1695             


Glu Leu  Asp Ile Ser Gly Arg  Ala Ser Gly Leu Pro  Ser Gly Thr 
    1700                 1705                 1710             


Glu Leu  Ser Gly Gln Ala Ser  Gly Ser Pro Asp Val  Ser Gly Glu 
    1715                 1720                 1725             


Ile Pro  Gly Leu Phe Gly Val  Ser Gly Gln Pro Ser  Gly Phe Pro 
    1730                 1735                 1740             


Asp Thr  Ser Gly Glu Thr Ser  Gly Val Thr Glu Leu  Ser Gly Leu 
    1745                 1750                 1755             


Ser Ser  Gly Gln Pro Gly Ile  Ser Gly Glu Ala Ser  Gly Val Leu 
    1760                 1765                 1770             


Tyr Gly  Thr Ser Gln Pro Phe  Gly Ile Thr Asp Leu  Ser Gly Glu 
    1775                 1780                 1785             


Thr Ser  Gly Val Pro Asp Leu  Ser Gly Gln Pro Ser  Gly Leu Pro 
    1790                 1795                 1800             


Gly Phe  Ser Gly Ala Thr Ser  Gly Val Pro Asp Leu  Val Ser Gly 
    1805                 1810                 1815             


Thr Thr  Ser Gly Ser Gly Glu  Ser Ser Gly Ile Thr  Phe Val Asp 
    1820                 1825                 1830             


Thr Ser  Leu Val Glu Val Ala  Pro Thr Thr Phe Lys  Glu Glu Glu 
    1835                 1840                 1845             


Gly Leu  Gly Ser Val Glu Leu  Ser Gly Leu Pro Ser  Gly Glu Ala 
    1850                 1855                 1860             


Asp Leu  Ser Gly Lys Ser Gly  Met Val Asp Val Ser  Gly Gln Phe 
    1865                 1870                 1875             


Ser Gly  Thr Val Asp Ser Ser  Gly Phe Thr Ser Gln  Thr Pro Glu 
    1880                 1885                 1890             


Phe Ser  Gly Leu Pro Ser Gly  Ile Ala Glu Val Ser  Gly Glu Ser 
    1895                 1900                 1905             


Ser Arg  Ala Glu Ile Gly Ser  Ser Leu Pro Ser Gly  Ala Tyr Tyr 
    1910                 1915                 1920             


Gly Ser  Gly Thr Pro Ser Ser  Phe Pro Thr Val Ser  Leu Val Asp 
    1925                 1930                 1935             


Arg Thr  Leu Val Glu Ser Val  Thr Gln Ala Pro Thr  Ala Gln Glu 
    1940                 1945                 1950             


Ala Gly  Glu Gly Pro Ser Gly  Ile Leu Glu Leu Ser  Gly Ala His 
    1955                 1960                 1965             


Ser Gly  Ala Pro Asp Met Ser  Gly Glu His Ser Gly  Phe Leu Asp 
    1970                 1975                 1980             


Leu Ser  Gly Leu Gln Ser Gly  Leu Ile Glu Pro Ser  Gly Glu Pro 
    1985                 1990                 1995             


Pro Gly  Thr Pro Tyr Phe Ser  Gly Asp Phe Ala Ser  Thr Thr Asn 
    2000                 2005                 2010             


Val Ser  Gly Glu Ser Ser Val  Ala Met Gly Thr Ser  Gly Glu Ala 
    2015                 2020                 2025             


Ser Gly  Leu Pro Glu Val Thr  Leu Ile Thr Ser Glu  Phe Val Glu 
    2030                 2035                 2040             


Gly Val  Thr Glu Pro Thr Ile  Ser Gln Glu Leu Gly  Gln Arg Pro 
    2045                 2050                 2055             


Pro Val  Thr His Thr Pro Gln  Leu Phe Glu Ser Ser  Gly Lys Val 
    2060                 2065                 2070             


Ser Thr  Ala Gly Asp Ile Ser  Gly Ala Thr Pro Val  Leu Pro Gly 
    2075                 2080                 2085             


Ser Gly  Val Glu Val Ser Ser  Val Pro Glu Ser Ser  Ser Glu Thr 
    2090                 2095                 2100             


Ser Ala  Tyr Pro Glu Ala Gly  Phe Gly Ala Ser Ala  Ala Pro Glu 
    2105                 2110                 2115             


Ala Ser  Arg Glu Asp Ser Gly  Ser Pro Asp Leu Ser  Glu Thr Thr 
    2120                 2125                 2130             


Ser Ala  Phe His Glu Ala Asn  Leu Glu Arg Ser Ser  Gly Leu Gly 
    2135                 2140                 2145             


Val Ser  Gly Ser Thr Leu Thr  Phe Gln Glu Gly Glu  Ala Ser Ala 
    2150                 2155                 2160             


Ala Pro  Glu Val Ser Gly Glu  Ser Thr Thr Thr Ser  Asp Val Gly 
    2165                 2170                 2175             


Thr Glu  Ala Pro Gly Leu Pro  Ser Ala Thr Pro Thr  Ala Ser Gly 
    2180                 2185                 2190             


Asp Arg  Thr Glu Ile Ser Gly  Asp Leu Ser Gly His  Thr Ser Gln 
    2195                 2200                 2205             


Leu Gly  Val Val Ile Ser Thr  Ser Ile Pro Glu Ser  Glu Trp Thr 
    2210                 2215                 2220             


Gln Gln  Thr Gln Arg Pro Ala  Glu Thr His Leu Glu  Ile Glu Ser 
    2225                 2230                 2235             


Ser Ser  Leu Leu Tyr Ser Gly  Glu Glu Thr His Thr  Val Glu Thr 
    2240                 2245                 2250             


Ala Thr  Ser Pro Thr Asp Ala  Ser Ile Pro Ala Ser  Pro Glu Trp 
    2255                 2260                 2265             


Lys Arg  Glu Ser Glu Ser Thr  Ala Ala Ala Pro Ala  Arg Ser Cys 
    2270                 2275                 2280             


Ala Glu  Glu Pro Cys Gly Ala  Gly Thr Cys Lys Glu  Thr Glu Gly 
    2285                 2290                 2295             


His Val  Ile Cys Leu Cys Pro  Pro Gly Tyr Thr Gly  Glu His Cys 
    2300                 2305                 2310             


Asn Ile  Asp Gln Glu Val Cys  Glu Glu Gly Trp Asn  Lys Tyr Gln 
    2315                 2320                 2325             


Gly His  Cys Tyr Arg His Phe  Pro Asp Arg Glu Thr  Trp Val Asp 
    2330                 2335                 2340             


Ala Glu  Arg Arg Cys Arg Glu  Gln Gln Ser His Leu  Ser Ser Ile 
    2345                 2350                 2355             


Val Thr  Pro Glu Glu Gln Glu  Phe Val Asn Asn Asn  Ala Gln Asp 
    2360                 2365                 2370             


Tyr Gln  Trp Ile Gly Leu Asn  Asp Arg Thr Ile Glu  Gly Asp Phe 
    2375                 2380                 2385             


Arg Trp  Ser Asp Gly His Pro  Met Gln Phe Glu Asn  Trp Arg Pro 
    2390                 2395                 2400             


Asn Gln  Pro Asp Asn Phe Phe  Ala Ala Gly Glu Asp  Cys Val Val 
    2405                 2410                 2415             


Met Ile  Trp His Glu Lys Gly  Glu Trp Asn Asp Val  Pro Cys Asn 
    2420                 2425                 2430             


Tyr His  Leu Pro Phe Thr Cys  Lys Lys Gly Thr Val  Ala Cys Gly 
    2435                 2440                 2445             


Glu Pro  Pro Val Val Glu His  Ala Arg Thr Phe Gly  Gln Lys Lys 
    2450                 2455                 2460             


Asp Arg  Tyr Glu Ile Asn Ser  Leu Val Arg Tyr Gln  Cys Thr Glu 
    2465                 2470                 2475             


Gly Phe  Val Gln Arg His Met  Pro Thr Ile Arg Cys  Gln Pro Ser 
    2480                 2485                 2490             


Gly His  Trp Glu Glu Pro Gln  Ile Thr Cys Thr Asp  Pro Thr Thr 
    2495                 2500                 2505             


Tyr Lys  Arg Arg Leu Gln Lys  Arg Ser Ser Arg His  Pro Arg Arg 
    2510                 2515                 2520             


Ser Arg  Pro Ser Thr Ala His  
    2525                 2530 


<210>  103
<211>  2492
<212>  PRT
<213>  Homo Sapiens

<400>  103

Met Thr Thr Leu Leu Trp Val Phe Val Thr Leu Arg Val Ile Thr Ala 
1               5                   10                  15      


Ala Val Thr Val Glu Thr Ser Asp His Asp Asn Ser Leu Ser Val Ser 
            20                  25                  30          


Ile Pro Gln Pro Ser Pro Leu Arg Val Leu Leu Gly Thr Ser Leu Thr 
        35                  40                  45              


Ile Pro Cys Tyr Phe Ile Asp Pro Met His Pro Val Thr Thr Ala Pro 
    50                  55                  60                  


Ser Thr Ala Pro Leu Ala Pro Arg Ile Lys Trp Ser Arg Val Ser Lys 
65                  70                  75                  80  


Glu Lys Glu Val Val Leu Leu Val Ala Thr Glu Gly Arg Val Arg Val 
                85                  90                  95      


Asn Ser Ala Tyr Gln Asp Lys Val Ser Leu Pro Asn Tyr Pro Ala Ile 
            100                 105                 110         


Pro Ser Asp Ala Thr Leu Glu Val Gln Ser Leu Arg Ser Asn Asp Ser 
        115                 120                 125             


Gly Val Tyr Arg Cys Glu Val Met His Gly Ile Glu Asp Ser Glu Ala 
    130                 135                 140                 


Thr Leu Glu Val Val Val Lys Gly Ile Val Phe His Tyr Arg Ala Ile 
145                 150                 155                 160 


Ser Thr Arg Tyr Thr Leu Asp Phe Asp Arg Ala Gln Arg Ala Cys Leu 
                165                 170                 175     


Gln Asn Ser Ala Ile Ile Ala Thr Pro Glu Gln Leu Gln Ala Ala Tyr 
            180                 185                 190         


Glu Asp Gly Phe His Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr 
        195                 200                 205             


Val Arg Tyr Pro Ile His Thr Pro Arg Glu Gly Cys Tyr Gly Asp Lys 
    210                 215                 220                 


Asp Glu Phe Pro Gly Val Arg Thr Tyr Gly Ile Arg Asp Thr Asn Glu 
225                 230                 235                 240 


Thr Tyr Asp Val Tyr Cys Phe Ala Glu Glu Met Glu Gly Glu Val Phe 
                245                 250                 255     


Tyr Ala Thr Ser Pro Glu Lys Phe Thr Phe Gln Glu Ala Ala Asn Glu 
            260                 265                 270         


Cys Arg Arg Leu Gly Ala Arg Leu Ala Thr Thr Gly Gln Leu Tyr Leu 
        275                 280                 285             


Ala Trp Gln Ala Gly Met Asp Met Cys Ser Ala Gly Trp Leu Ala Asp 
    290                 295                 300                 


Arg Ser Val Arg Tyr Pro Ile Ser Lys Ala Arg Pro Asn Cys Gly Gly 
305                 310                 315                 320 


Asn Leu Leu Gly Val Arg Thr Val Tyr Val His Ala Asn Gln Thr Gly 
                325                 330                 335     


Tyr Pro Asp Pro Ser Ser Arg Tyr Asp Ala Ile Cys Tyr Thr Gly Glu 
            340                 345                 350         


Asp Phe Val Asp Ile Pro Glu Asn Phe Phe Gly Val Gly Gly Glu Glu 
        355                 360                 365             


Asp Ile Thr Val Gln Thr Val Thr Trp Pro Asp Met Glu Leu Pro Leu 
    370                 375                 380                 


Pro Arg Asn Ile Thr Glu Gly Glu Ala Arg Gly Ser Val Ile Leu Thr 
385                 390                 395                 400 


Val Lys Pro Ile Phe Glu Val Ser Pro Ser Pro Leu Glu Pro Glu Glu 
                405                 410                 415     


Pro Phe Thr Phe Ala Pro Glu Ile Gly Ala Thr Ala Phe Ala Glu Val 
            420                 425                 430         


Glu Asn Glu Thr Gly Glu Ala Thr Arg Pro Trp Gly Phe Pro Thr Pro 
        435                 440                 445             


Gly Leu Gly Pro Ala Thr Ala Phe Thr Ser Glu Asp Leu Val Val Gln 
    450                 455                 460                 


Val Thr Ala Val Pro Gly Gln Pro His Leu Pro Gly Gly Val Val Phe 
465                 470                 475                 480 


His Tyr Arg Pro Gly Pro Thr Arg Tyr Ser Leu Thr Phe Glu Glu Ala 
                485                 490                 495     


Gln Gln Ala Cys Leu Arg Thr Gly Ala Val Ile Ala Ser Pro Glu Gln 
            500                 505                 510         


Leu Gln Ala Ala Tyr Glu Ala Gly Tyr Glu Gln Cys Asp Ala Gly Trp 
        515                 520                 525             


Leu Arg Asp Gln Thr Val Arg Tyr Pro Ile Val Ser Pro Arg Thr Pro 
    530                 535                 540                 


Cys Val Gly Asp Lys Asp Ser Ser Pro Gly Val Arg Thr Tyr Gly Val 
545                 550                 555                 560 


Arg Pro Ser Thr Glu Thr Tyr Asp Val Tyr Cys Phe Val Asp Arg Leu 
                565                 570                 575     


Glu Gly Glu Val Phe Phe Ala Thr Arg Leu Glu Gln Phe Thr Phe Gln 
            580                 585                 590         


Glu Ala Leu Glu Phe Cys Glu Ser His Asn Ala Thr Leu Ala Thr Thr 
        595                 600                 605             


Gly Gln Leu Tyr Ala Ala Trp Ser Arg Gly Leu Asp Lys Cys Tyr Ala 
    610                 615                 620                 


Gly Trp Leu Ala Asp Gly Ser Leu Arg Tyr Pro Ile Val Thr Pro Arg 
625                 630                 635                 640 


Pro Ala Cys Gly Gly Asp Lys Pro Gly Val Arg Thr Val Tyr Leu Tyr 
                645                 650                 655     


Pro Asn Gln Thr Gly Leu Pro Asp Pro Leu Ser Arg His His Ala Phe 
            660                 665                 670         


Cys Phe Arg Gly Ile Ser Ala Val Pro Ser Pro Gly Glu Glu Glu Gly 
        675                 680                 685             


Gly Thr Pro Thr Ser Pro Ser Gly Val Glu Glu Trp Ile Val Thr Gln 
    690                 695                 700                 


Val Val Pro Gly Val Ala Ala Val Pro Val Glu Glu Glu Thr Thr Ala 
705                 710                 715                 720 


Val Pro Ser Gly Glu Thr Thr Ala Ile Leu Glu Phe Thr Thr Glu Pro 
                725                 730                 735     


Glu Asn Gln Thr Glu Trp Glu Pro Ala Tyr Thr Pro Val Gly Thr Ser 
            740                 745                 750         


Pro Leu Pro Gly Ile Leu Pro Thr Trp Pro Pro Thr Gly Ala Ala Thr 
        755                 760                 765             


Glu Glu Ser Thr Glu Gly Pro Ser Ala Thr Glu Val Pro Ser Ala Ser 
    770                 775                 780                 


Glu Glu Pro Ser Pro Ser Glu Val Pro Phe Pro Ser Glu Glu Pro Ser 
785                 790                 795                 800 


Pro Ser Glu Glu Pro Phe Pro Ser Val Arg Pro Phe Pro Ser Val Glu 
                805                 810                 815     


Leu Phe Pro Ser Glu Glu Pro Phe Pro Ser Lys Glu Pro Ser Pro Ser 
            820                 825                 830         


Glu Glu Pro Ser Ala Ser Glu Glu Pro Tyr Thr Pro Ser Pro Pro Val 
        835                 840                 845             


Pro Ser Trp Thr Glu Leu Pro Ser Ser Gly Glu Glu Ser Gly Ala Pro 
    850                 855                 860                 


Asp Val Ser Gly Asp Phe Thr Gly Ser Gly Asp Val Ser Gly His Leu 
865                 870                 875                 880 


Asp Phe Ser Gly Gln Leu Ser Gly Asp Arg Ala Ser Gly Leu Pro Ser 
                885                 890                 895     


Gly Asp Leu Asp Ser Ser Gly Leu Thr Ser Thr Val Gly Ser Gly Leu 
            900                 905                 910         


Pro Val Glu Ser Gly Leu Pro Ser Gly Asp Glu Glu Arg Ile Glu Trp 
        915                 920                 925             


Pro Ser Thr Pro Thr Val Gly Glu Leu Pro Ser Gly Ala Glu Ile Leu 
    930                 935                 940                 


Glu Gly Ser Ala Ser Gly Val Gly Asp Leu Ser Gly Leu Pro Ser Gly 
945                 950                 955                 960 


Glu Val Leu Glu Thr Ser Ala Ser Gly Val Gly Asp Leu Ser Gly Leu 
                965                 970                 975     


Pro Ser Gly Glu Val Leu Glu Thr Thr Ala Pro Gly Val Glu Asp Ile 
            980                 985                 990         


Ser Gly Leu Pro Ser Gly Glu Val  Leu Glu Thr Thr Ala  Pro Gly Val 
        995                 1000                 1005             


Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu Val Leu  Glu Thr Thr 
    1010                 1015                 1020             


Ala Pro  Gly Val Glu Asp Ile  Ser Gly Leu Pro Ser  Gly Glu Val 
    1025                 1030                 1035             


Leu Glu  Thr Thr Ala Pro Gly  Val Glu Asp Ile Ser  Gly Leu Pro 
    1040                 1045                 1050             


Ser Gly  Glu Val Leu Glu Thr  Thr Ala Pro Gly Val  Glu Asp Ile 
    1055                 1060                 1065             


Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu Thr Thr  Ala Pro Gly 
    1070                 1075                 1080             


Val Glu  Asp Ile Ser Gly Leu  Pro Ser Gly Glu Val  Leu Glu Thr 
    1085                 1090                 1095             


Ala Ala  Pro Gly Val Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu 
    1100                 1105                 1110             


Val Leu  Glu Thr Ala Ala Pro  Gly Val Glu Asp Ile  Ser Gly Leu 
    1115                 1120                 1125             


Pro Ser  Gly Glu Val Leu Glu  Thr Ala Ala Pro Gly  Val Glu Asp 
    1130                 1135                 1140             


Ile Ser  Gly Leu Pro Ser Gly  Glu Val Leu Glu Thr  Ala Ala Pro 
    1145                 1150                 1155             


Gly Val  Glu Asp Ile Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu 
    1160                 1165                 1170             


Thr Ala  Ala Pro Gly Val Glu  Asp Ile Ser Gly Leu  Pro Ser Gly 
    1175                 1180                 1185             


Glu Val  Leu Glu Thr Ala Ala  Pro Gly Val Glu Asp  Ile Ser Gly 
    1190                 1195                 1200             


Leu Pro  Ser Gly Glu Val Leu  Glu Thr Ala Ala Pro  Gly Val Glu 
    1205                 1210                 1215             


Asp Ile  Ser Gly Leu Pro Ser  Gly Glu Val Leu Glu  Thr Ala Ala 
    1220                 1225                 1230             


Pro Gly  Val Glu Asp Ile Ser  Gly Leu Pro Ser Gly  Glu Val Leu 
    1235                 1240                 1245             


Glu Thr  Ala Ala Pro Gly Val  Glu Asp Ile Ser Gly  Leu Pro Ser 
    1250                 1255                 1260             


Gly Glu  Val Leu Glu Thr Ala  Ala Pro Gly Val Glu  Asp Ile Ser 
    1265                 1270                 1275             


Gly Leu  Pro Ser Gly Glu Val  Leu Glu Thr Ala Ala  Pro Gly Val 
    1280                 1285                 1290             


Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu Val Leu  Glu Thr Ala 
    1295                 1300                 1305             


Ala Pro  Gly Val Glu Asp Ile  Ser Gly Leu Pro Ser  Gly Glu Val 
    1310                 1315                 1320             


Leu Glu  Thr Ala Ala Pro Gly  Val Glu Asp Ile Ser  Gly Leu Pro 
    1325                 1330                 1335             


Ser Gly  Glu Val Leu Glu Thr  Ala Ala Pro Gly Val  Glu Asp Ile 
    1340                 1345                 1350             


Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu Thr Ala  Ala Pro Gly 
    1355                 1360                 1365             


Val Glu  Asp Ile Ser Gly Leu  Pro Ser Gly Glu Val  Leu Glu Thr 
    1370                 1375                 1380             


Ala Ala  Pro Gly Val Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu 
    1385                 1390                 1395             


Val Leu  Glu Thr Thr Ala Pro  Gly Val Glu Glu Ile  Ser Gly Leu 
    1400                 1405                 1410             


Pro Ser  Gly Glu Val Leu Glu  Thr Thr Ala Pro Gly  Val Asp Glu 
    1415                 1420                 1425             


Ile Ser  Gly Leu Pro Ser Gly  Glu Val Leu Glu Thr  Thr Ala Pro 
    1430                 1435                 1440             


Gly Val  Glu Glu Ile Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu 
    1445                 1450                 1455             


Thr Ser  Thr Ser Ala Val Gly  Asp Leu Ser Gly Leu  Pro Ser Gly 
    1460                 1465                 1470             


Gly Glu  Val Leu Glu Ile Ser  Val Ser Gly Val Glu  Asp Ile Ser 
    1475                 1480                 1485             


Gly Leu  Pro Ser Gly Glu Val  Val Glu Thr Ser Ala  Ser Gly Ile 
    1490                 1495                 1500             


Glu Asp  Val Ser Glu Leu Pro  Ser Gly Glu Gly Leu  Glu Thr Ser 
    1505                 1510                 1515             


Ala Ser  Gly Val Glu Asp Leu  Ser Arg Leu Pro Ser  Gly Glu Glu 
    1520                 1525                 1530             


Val Leu  Glu Ile Ser Ala Ser  Gly Phe Gly Asp Leu  Ser Gly Leu 
    1535                 1540                 1545             


Pro Ser  Gly Gly Glu Gly Leu  Glu Thr Ser Ala Ser  Glu Val Gly 
    1550                 1555                 1560             


Thr Asp  Leu Ser Gly Leu Pro  Ser Gly Arg Glu Gly  Leu Glu Thr 
    1565                 1570                 1575             


Ser Ala  Ser Gly Ala Glu Asp  Leu Ser Gly Leu Pro  Ser Gly Lys 
    1580                 1585                 1590             


Glu Asp  Leu Val Gly Ser Ala  Ser Gly Asp Leu Asp  Leu Gly Lys 
    1595                 1600                 1605             


Leu Pro  Ser Gly Thr Leu Gly  Ser Gly Gln Ala Pro  Glu Thr Ser 
    1610                 1615                 1620             


Gly Leu  Pro Ser Gly Phe Ser  Gly Glu Tyr Ser Gly  Val Asp Leu 
    1625                 1630                 1635             


Gly Ser  Gly Pro Pro Ser Gly  Leu Pro Asp Phe Ser  Gly Leu Pro 
    1640                 1645                 1650             


Ser Gly  Phe Pro Thr Val Ser  Leu Val Asp Ser Thr  Leu Val Glu 
    1655                 1660                 1665             


Val Val  Thr Ala Ser Thr Ala  Ser Glu Leu Glu Gly  Arg Gly Thr 
    1670                 1675                 1680             


Ile Gly  Ile Ser Gly Ala Gly  Glu Ile Ser Gly Leu  Pro Ser Ser 
    1685                 1690                 1695             


Glu Leu  Asp Ile Ser Gly Arg  Ala Ser Gly Leu Pro  Ser Gly Thr 
    1700                 1705                 1710             


Glu Leu  Ser Gly Gln Ala Ser  Gly Ser Pro Asp Val  Ser Gly Glu 
    1715                 1720                 1725             


Ile Pro  Gly Leu Phe Gly Val  Ser Gly Gln Pro Ser  Gly Phe Pro 
    1730                 1735                 1740             


Asp Thr  Ser Gly Glu Thr Ser  Gly Val Thr Glu Leu  Ser Gly Leu 
    1745                 1750                 1755             


Ser Ser  Gly Gln Pro Gly Ile  Ser Gly Glu Ala Ser  Gly Val Leu 
    1760                 1765                 1770             


Tyr Gly  Thr Ser Gln Pro Phe  Gly Ile Thr Asp Leu  Ser Gly Glu 
    1775                 1780                 1785             


Thr Ser  Gly Val Pro Asp Leu  Ser Gly Gln Pro Ser  Gly Leu Pro 
    1790                 1795                 1800             


Gly Phe  Ser Gly Ala Thr Ser  Gly Val Pro Asp Leu  Val Ser Gly 
    1805                 1810                 1815             


Thr Thr  Ser Gly Ser Gly Glu  Ser Ser Gly Ile Thr  Phe Val Asp 
    1820                 1825                 1830             


Thr Ser  Leu Val Glu Val Ala  Pro Thr Thr Phe Lys  Glu Glu Glu 
    1835                 1840                 1845             


Gly Leu  Gly Ser Val Glu Leu  Ser Gly Leu Pro Ser  Gly Glu Ala 
    1850                 1855                 1860             


Asp Leu  Ser Gly Lys Ser Gly  Met Val Asp Val Ser  Gly Gln Phe 
    1865                 1870                 1875             


Ser Gly  Thr Val Asp Ser Ser  Gly Phe Thr Ser Gln  Thr Pro Glu 
    1880                 1885                 1890             


Phe Ser  Gly Leu Pro Ser Gly  Ile Ala Glu Val Ser  Gly Glu Ser 
    1895                 1900                 1905             


Ser Arg  Ala Glu Ile Gly Ser  Ser Leu Pro Ser Gly  Ala Tyr Tyr 
    1910                 1915                 1920             


Gly Ser  Gly Thr Pro Ser Ser  Phe Pro Thr Val Ser  Leu Val Asp 
    1925                 1930                 1935             


Arg Thr  Leu Val Glu Ser Val  Thr Gln Ala Pro Thr  Ala Gln Glu 
    1940                 1945                 1950             


Ala Gly  Glu Gly Pro Ser Gly  Ile Leu Glu Leu Ser  Gly Ala His 
    1955                 1960                 1965             


Ser Gly  Ala Pro Asp Met Ser  Gly Glu His Ser Gly  Phe Leu Asp 
    1970                 1975                 1980             


Leu Ser  Gly Leu Gln Ser Gly  Leu Ile Glu Pro Ser  Gly Glu Pro 
    1985                 1990                 1995             


Pro Gly  Thr Pro Tyr Phe Ser  Gly Asp Phe Ala Ser  Thr Thr Asn 
    2000                 2005                 2010             


Val Ser  Gly Glu Ser Ser Val  Ala Met Gly Thr Ser  Gly Glu Ala 
    2015                 2020                 2025             


Ser Gly  Leu Pro Glu Val Thr  Leu Ile Thr Ser Glu  Phe Val Glu 
    2030                 2035                 2040             


Gly Val  Thr Glu Pro Thr Ile  Ser Gln Glu Leu Gly  Gln Arg Pro 
    2045                 2050                 2055             


Pro Val  Thr His Thr Pro Gln  Leu Phe Glu Ser Ser  Gly Lys Val 
    2060                 2065                 2070             


Ser Thr  Ala Gly Asp Ile Ser  Gly Ala Thr Pro Val  Leu Pro Gly 
    2075                 2080                 2085             


Ser Gly  Val Glu Val Ser Ser  Val Pro Glu Ser Ser  Ser Glu Thr 
    2090                 2095                 2100             


Ser Ala  Tyr Pro Glu Ala Gly  Phe Gly Ala Ser Ala  Ala Pro Glu 
    2105                 2110                 2115             


Ala Ser  Arg Glu Asp Ser Gly  Ser Pro Asp Leu Ser  Glu Thr Thr 
    2120                 2125                 2130             


Ser Ala  Phe His Glu Ala Asn  Leu Glu Arg Ser Ser  Gly Leu Gly 
    2135                 2140                 2145             


Val Ser  Gly Ser Thr Leu Thr  Phe Gln Glu Gly Glu  Ala Ser Ala 
    2150                 2155                 2160             


Ala Pro  Glu Val Ser Gly Glu  Ser Thr Thr Thr Ser  Asp Val Gly 
    2165                 2170                 2175             


Thr Glu  Ala Pro Gly Leu Pro  Ser Ala Thr Pro Thr  Ala Ser Gly 
    2180                 2185                 2190             


Asp Arg  Thr Glu Ile Ser Gly  Asp Leu Ser Gly His  Thr Ser Gln 
    2195                 2200                 2205             


Leu Gly  Val Val Ile Ser Thr  Ser Ile Pro Glu Ser  Glu Trp Thr 
    2210                 2215                 2220             


Gln Gln  Thr Gln Arg Pro Ala  Glu Thr His Leu Glu  Ile Glu Ser 
    2225                 2230                 2235             


Ser Ser  Leu Leu Tyr Ser Gly  Glu Glu Thr His Thr  Val Glu Thr 
    2240                 2245                 2250             


Ala Thr  Ser Pro Thr Asp Ala  Ser Ile Pro Ala Ser  Pro Glu Trp 
    2255                 2260                 2265             


Lys Arg  Glu Ser Glu Ser Thr  Ala Ala Asp Gln Glu  Val Cys Glu 
    2270                 2275                 2280             


Glu Gly  Trp Asn Lys Tyr Gln  Gly His Cys Tyr Arg  His Phe Pro 
    2285                 2290                 2295             


Asp Arg  Glu Thr Trp Val Asp  Ala Glu Arg Arg Cys  Arg Glu Gln 
    2300                 2305                 2310             


Gln Ser  His Leu Ser Ser Ile  Val Thr Pro Glu Glu  Gln Glu Phe 
    2315                 2320                 2325             


Val Asn  Asn Asn Ala Gln Asp  Tyr Gln Trp Ile Gly  Leu Asn Asp 
    2330                 2335                 2340             


Arg Thr  Ile Glu Gly Asp Phe  Arg Trp Ser Asp Gly  His Pro Met 
    2345                 2350                 2355             


Gln Phe  Glu Asn Trp Arg Pro  Asn Gln Pro Asp Asn  Phe Phe Ala 
    2360                 2365                 2370             


Ala Gly  Glu Asp Cys Val Val  Met Ile Trp His Glu  Lys Gly Glu 
    2375                 2380                 2385             


Trp Asn  Asp Val Pro Cys Asn  Tyr His Leu Pro Phe  Thr Cys Lys 
    2390                 2395                 2400             


Lys Gly  Thr Val Ala Cys Gly  Glu Pro Pro Val Val  Glu His Ala 
    2405                 2410                 2415             


Arg Thr  Phe Gly Gln Lys Lys  Asp Arg Tyr Glu Ile  Asn Ser Leu 
    2420                 2425                 2430             


Val Arg  Tyr Gln Cys Thr Glu  Gly Phe Val Gln Arg  His Met Pro 
    2435                 2440                 2445             


Thr Ile  Arg Cys Gln Pro Ser  Gly His Trp Glu Glu  Pro Gln Ile 
    2450                 2455                 2460             


Thr Cys  Thr Asp Pro Thr Thr  Tyr Lys Arg Arg Leu  Gln Lys Arg 
    2465                 2470                 2475             


Ser Ser  Arg His Pro Arg Arg  Ser Arg Pro Ser Thr  Ala His 
    2480                 2485                 2490         


<210>  104
<211>  721
<212>  PRT
<213>  Homo Sapiens

<400>  104

Met Thr Thr Leu Leu Trp Val Phe Val Thr Leu Arg Val Ile Thr Ala 
1               5                   10                  15      


Ala Val Thr Val Glu Thr Ser Asp His Asp Asn Ser Leu Ser Val Ser 
            20                  25                  30          


Ile Pro Gln Pro Ser Pro Leu Arg Val Leu Leu Gly Thr Ser Leu Thr 
        35                  40                  45              


Ile Pro Cys Tyr Phe Ile Asp Pro Met His Pro Val Thr Thr Ala Pro 
    50                  55                  60                  


Ser Thr Ala Pro Leu Ala Pro Arg Ile Lys Trp Ser Arg Val Ser Lys 
65                  70                  75                  80  


Glu Lys Glu Val Val Leu Leu Val Ala Thr Glu Gly Arg Val Arg Val 
                85                  90                  95      


Asn Ser Ala Tyr Gln Asp Lys Val Ser Leu Pro Asn Tyr Pro Ala Ile 
            100                 105                 110         


Pro Ser Asp Ala Thr Leu Glu Val Gln Ser Leu Arg Ser Asn Asp Ser 
        115                 120                 125             


Gly Val Tyr Arg Cys Glu Val Met His Gly Ile Glu Asp Ser Glu Ala 
    130                 135                 140                 


Thr Leu Glu Val Val Val Lys Gly Ile Val Phe His Tyr Arg Ala Ile 
145                 150                 155                 160 


Ser Thr Arg Tyr Thr Leu Asp Phe Asp Arg Ala Gln Arg Ala Cys Leu 
                165                 170                 175     


Gln Asn Ser Ala Ile Ile Ala Thr Pro Glu Gln Leu Gln Ala Ala Tyr 
            180                 185                 190         


Glu Asp Gly Phe His Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr 
        195                 200                 205             


Val Arg Tyr Pro Ile His Thr Pro Arg Glu Gly Cys Tyr Gly Asp Lys 
    210                 215                 220                 


Asp Glu Phe Pro Gly Val Arg Thr Tyr Gly Ile Arg Asp Thr Asn Glu 
225                 230                 235                 240 


Thr Tyr Asp Val Tyr Cys Phe Ala Glu Glu Met Glu Gly Glu Val Phe 
                245                 250                 255     


Tyr Ala Thr Ser Pro Glu Lys Phe Thr Phe Gln Glu Ala Ala Asn Glu 
            260                 265                 270         


Cys Arg Arg Leu Gly Ala Arg Leu Ala Thr Thr Gly Gln Leu Tyr Leu 
        275                 280                 285             


Ala Trp Gln Ala Gly Met Asp Met Cys Ser Ala Gly Trp Leu Ala Asp 
    290                 295                 300                 


Arg Ser Val Arg Tyr Pro Ile Ser Lys Ala Arg Pro Asn Cys Gly Gly 
305                 310                 315                 320 


Asn Leu Leu Gly Val Arg Thr Val Tyr Val His Ala Asn Gln Thr Gly 
                325                 330                 335     


Tyr Pro Asp Pro Ser Ser Arg Tyr Asp Ala Ile Cys Tyr Thr Gly Glu 
            340                 345                 350         


Asp Phe Val Asp Ile Pro Glu Asn Phe Phe Gly Val Gly Gly Glu Glu 
        355                 360                 365             


Asp Ile Thr Val Gln Thr Val Thr Trp Pro Asp Met Glu Leu Pro Leu 
    370                 375                 380                 


Pro Arg Asn Ile Thr Glu Gly Glu Ala Arg Gly Ser Val Ile Leu Thr 
385                 390                 395                 400 


Val Lys Pro Ile Phe Glu Val Ser Pro Ser Pro Leu Glu Pro Glu Glu 
                405                 410                 415     


Pro Phe Thr Phe Ala Pro Glu Ile Gly Ala Thr Ala Phe Ala Glu Val 
            420                 425                 430         


Glu Asn Glu Thr Gly Glu Ala Thr Arg Pro Trp Gly Phe Pro Thr Pro 
        435                 440                 445             


Gly Leu Gly Pro Ala Thr Ala Phe Thr Ser Glu Asp Leu Val Val Gln 
    450                 455                 460                 


Val Thr Ala Val Pro Gly Gln Pro His Leu Pro Gly Gly Val Val Phe 
465                 470                 475                 480 


His Tyr Arg Pro Gly Pro Thr Arg Tyr Ser Leu Thr Phe Glu Glu Ala 
                485                 490                 495     


Gln Gln Ala Cys Leu Arg Thr Gly Ala Val Ile Ala Ser Pro Glu Gln 
            500                 505                 510         


Leu Gln Ala Ala Tyr Glu Ala Gly Tyr Glu Gln Cys Asp Ala Gly Trp 
        515                 520                 525             


Leu Arg Asp Gln Thr Val Arg Tyr Pro Ile Val Ser Pro Arg Thr Pro 
    530                 535                 540                 


Cys Val Gly Asp Lys Asp Ser Ser Pro Gly Val Arg Thr Tyr Gly Val 
545                 550                 555                 560 


Arg Pro Ser Thr Glu Thr Tyr Asp Val Tyr Cys Phe Val Asp Arg Leu 
                565                 570                 575     


Glu Gly Glu Val Phe Phe Ala Thr Arg Leu Glu Gln Phe Thr Phe Gln 
            580                 585                 590         


Glu Ala Leu Glu Phe Cys Glu Ser His Asn Ala Thr Leu Ala Thr Thr 
        595                 600                 605             


Gly Gln Leu Tyr Ala Ala Trp Ser Arg Gly Leu Asp Lys Cys Tyr Ala 
    610                 615                 620                 


Gly Trp Leu Ala Asp Gly Ser Leu Arg Tyr Pro Ile Val Thr Pro Arg 
625                 630                 635                 640 


Pro Ala Cys Gly Gly Asp Lys Pro Gly Val Arg Thr Val Tyr Leu Tyr 
                645                 650                 655     


Pro Asn Gln Thr Gly Leu Pro Asp Pro Leu Ser Arg His His Ala Phe 
            660                 665                 670         


Cys Phe Arg Gly Met Gln Pro His Phe Gly Ser Asn Ser Pro Phe Cys 
        675                 680                 685             


Leu Glu Arg Thr Pro Leu Gly Ser Pro Asp Pro Ala Thr Thr Gln Tyr 
    690                 695                 700                 


Pro Ile His Gln Ser Lys Lys Met Ser Val Pro Leu Gly Gln Ser Gln 
705                 710                 715                 720 


Leu 
    


<210>  105
<211>  2530
<212>  PRT
<213>  Homo Sapiens

<400>  105

Met Thr Thr Leu Leu Trp Val Phe Val Thr Leu Arg Val Ile Thr Ala 
1               5                   10                  15      


Ala Val Thr Val Glu Thr Ser Asp His Asp Asn Ser Leu Ser Val Ser 
            20                  25                  30          


Ile Pro Gln Pro Ser Pro Leu Arg Val Leu Leu Gly Thr Ser Leu Thr 
        35                  40                  45              


Ile Pro Cys Tyr Phe Ile Asp Pro Met His Pro Val Thr Thr Ala Pro 
    50                  55                  60                  


Ser Thr Ala Pro Leu Ala Pro Arg Ile Lys Trp Ser Arg Val Ser Lys 
65                  70                  75                  80  


Glu Lys Glu Val Val Leu Leu Val Ala Thr Glu Gly Arg Val Arg Val 
                85                  90                  95      


Asn Ser Ala Tyr Gln Asp Lys Val Ser Leu Pro Asn Tyr Pro Ala Ile 
            100                 105                 110         


Pro Ser Asp Ala Thr Leu Glu Val Gln Ser Leu Arg Ser Asn Asp Ser 
        115                 120                 125             


Gly Val Tyr Arg Cys Glu Val Met His Gly Ile Glu Asp Ser Glu Ala 
    130                 135                 140                 


Thr Leu Glu Val Val Val Lys Gly Ile Val Phe His Tyr Arg Ala Ile 
145                 150                 155                 160 


Ser Thr Arg Tyr Thr Leu Asp Phe Asp Arg Ala Gln Arg Ala Cys Leu 
                165                 170                 175     


Gln Asn Ser Ala Ile Ile Ala Thr Pro Glu Gln Leu Gln Ala Ala Tyr 
            180                 185                 190         


Glu Asp Gly Phe His Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr 
        195                 200                 205             


Val Arg Tyr Pro Ile His Thr Pro Arg Glu Gly Cys Tyr Gly Asp Lys 
    210                 215                 220                 


Asp Glu Phe Pro Gly Val Arg Thr Tyr Gly Ile Arg Asp Thr Asn Glu 
225                 230                 235                 240 


Thr Tyr Asp Val Tyr Cys Phe Ala Glu Glu Met Glu Gly Glu Val Phe 
                245                 250                 255     


Tyr Ala Thr Ser Pro Glu Lys Phe Thr Phe Gln Glu Ala Ala Asn Glu 
            260                 265                 270         


Cys Arg Arg Leu Gly Ala Arg Leu Ala Thr Thr Gly Gln Leu Tyr Leu 
        275                 280                 285             


Ala Trp Gln Ala Gly Met Asp Met Cys Ser Ala Gly Trp Leu Ala Asp 
    290                 295                 300                 


Arg Ser Val Arg Tyr Pro Ile Ser Lys Ala Arg Pro Asn Cys Gly Gly 
305                 310                 315                 320 


Asn Leu Leu Gly Val Arg Thr Val Tyr Val His Ala Asn Gln Thr Gly 
                325                 330                 335     


Tyr Pro Asp Pro Ser Ser Arg Tyr Asp Ala Ile Cys Tyr Thr Gly Glu 
            340                 345                 350         


Asp Phe Val Asp Ile Pro Glu Asn Phe Phe Gly Val Gly Gly Glu Glu 
        355                 360                 365             


Asp Ile Thr Val Gln Thr Val Thr Trp Pro Asp Met Glu Leu Pro Leu 
    370                 375                 380                 


Pro Arg Asn Ile Thr Glu Gly Glu Ala Arg Gly Ser Val Ile Leu Thr 
385                 390                 395                 400 


Val Lys Pro Ile Phe Glu Val Ser Pro Ser Pro Leu Glu Pro Glu Glu 
                405                 410                 415     


Pro Phe Thr Phe Ala Pro Glu Ile Gly Ala Thr Ala Phe Ala Glu Val 
            420                 425                 430         


Glu Asn Glu Thr Gly Glu Ala Thr Arg Pro Trp Gly Phe Pro Thr Pro 
        435                 440                 445             


Gly Leu Gly Pro Ala Thr Ala Phe Thr Ser Glu Asp Leu Val Val Gln 
    450                 455                 460                 


Val Thr Ala Val Pro Gly Gln Pro His Leu Pro Gly Gly Val Val Phe 
465                 470                 475                 480 


His Tyr Arg Pro Gly Pro Thr Arg Tyr Ser Leu Thr Phe Glu Glu Ala 
                485                 490                 495     


Gln Gln Ala Cys Leu Arg Thr Gly Ala Val Ile Ala Ser Pro Glu Gln 
            500                 505                 510         


Leu Gln Ala Ala Tyr Glu Ala Gly Tyr Glu Gln Cys Asp Ala Gly Trp 
        515                 520                 525             


Leu Arg Asp Gln Thr Val Arg Tyr Pro Ile Val Ser Pro Arg Thr Pro 
    530                 535                 540                 


Cys Val Gly Asp Lys Asp Ser Ser Pro Gly Val Arg Thr Tyr Gly Val 
545                 550                 555                 560 


Arg Pro Ser Thr Glu Thr Tyr Asp Val Tyr Cys Phe Val Asp Arg Leu 
                565                 570                 575     


Glu Gly Glu Val Phe Phe Ala Thr Arg Leu Glu Gln Phe Thr Phe Gln 
            580                 585                 590         


Glu Ala Leu Glu Phe Cys Glu Ser His Asn Ala Thr Leu Ala Thr Thr 
        595                 600                 605             


Gly Gln Leu Tyr Ala Ala Trp Ser Arg Gly Leu Asp Lys Cys Tyr Ala 
    610                 615                 620                 


Gly Trp Leu Ala Asp Gly Ser Leu Arg Tyr Pro Ile Val Thr Pro Arg 
625                 630                 635                 640 


Pro Ala Cys Gly Gly Asp Lys Pro Gly Val Arg Thr Val Tyr Leu Tyr 
                645                 650                 655     


Pro Asn Gln Thr Gly Leu Pro Asp Pro Leu Ser Arg His His Ala Phe 
            660                 665                 670         


Cys Phe Arg Gly Ile Ser Ala Val Pro Ser Pro Gly Glu Glu Glu Gly 
        675                 680                 685             


Gly Thr Pro Thr Ser Pro Ser Gly Val Glu Glu Trp Ile Val Thr Gln 
    690                 695                 700                 


Val Val Pro Gly Val Ala Ala Val Pro Val Glu Glu Glu Thr Thr Ala 
705                 710                 715                 720 


Val Pro Ser Gly Glu Thr Thr Ala Ile Leu Glu Phe Thr Thr Glu Pro 
                725                 730                 735     


Glu Asn Gln Thr Glu Trp Glu Pro Ala Tyr Thr Pro Val Gly Thr Ser 
            740                 745                 750         


Pro Leu Pro Gly Ile Leu Pro Thr Trp Pro Pro Thr Gly Ala Ala Thr 
        755                 760                 765             


Glu Glu Ser Thr Glu Gly Pro Ser Ala Thr Glu Val Pro Ser Ala Ser 
    770                 775                 780                 


Glu Glu Pro Ser Pro Ser Glu Val Pro Phe Pro Ser Glu Glu Pro Ser 
785                 790                 795                 800 


Pro Ser Glu Glu Pro Phe Pro Ser Val Arg Pro Phe Pro Ser Val Glu 
                805                 810                 815     


Leu Phe Pro Ser Glu Glu Pro Phe Pro Ser Lys Glu Pro Ser Pro Ser 
            820                 825                 830         


Glu Glu Pro Ser Ala Ser Glu Glu Pro Tyr Thr Pro Ser Pro Pro Val 
        835                 840                 845             


Pro Ser Trp Thr Glu Leu Pro Ser Ser Gly Glu Glu Ser Gly Ala Pro 
    850                 855                 860                 


Asp Val Ser Gly Asp Phe Thr Gly Ser Gly Asp Val Ser Gly His Leu 
865                 870                 875                 880 


Asp Phe Ser Gly Gln Leu Ser Gly Asp Arg Ala Ser Gly Leu Pro Ser 
                885                 890                 895     


Gly Asp Leu Asp Ser Ser Gly Leu Thr Ser Thr Val Gly Ser Gly Leu 
            900                 905                 910         


Pro Val Glu Ser Gly Leu Pro Ser Gly Asp Glu Glu Arg Ile Glu Trp 
        915                 920                 925             


Pro Ser Thr Pro Thr Val Gly Glu Leu Pro Ser Gly Ala Glu Ile Leu 
    930                 935                 940                 


Glu Gly Ser Ala Ser Gly Val Gly Asp Leu Ser Gly Leu Pro Ser Gly 
945                 950                 955                 960 


Glu Val Leu Glu Thr Ser Ala Ser Gly Val Gly Asp Leu Ser Gly Leu 
                965                 970                 975     


Pro Ser Gly Glu Val Leu Glu Thr Thr Ala Pro Gly Val Glu Asp Ile 
            980                 985                 990         


Ser Gly Leu Pro Ser Gly Glu Val  Leu Glu Thr Thr Ala  Pro Gly Val 
        995                 1000                 1005             


Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu Val Leu  Glu Thr Thr 
    1010                 1015                 1020             


Ala Pro  Gly Val Glu Asp Ile  Ser Gly Leu Pro Ser  Gly Glu Val 
    1025                 1030                 1035             


Leu Glu  Thr Thr Ala Pro Gly  Val Glu Asp Ile Ser  Gly Leu Pro 
    1040                 1045                 1050             


Ser Gly  Glu Val Leu Glu Thr  Thr Ala Pro Gly Val  Glu Asp Ile 
    1055                 1060                 1065             


Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu Thr Thr  Ala Pro Gly 
    1070                 1075                 1080             


Val Glu  Asp Ile Ser Gly Leu  Pro Ser Gly Glu Val  Leu Glu Thr 
    1085                 1090                 1095             


Ala Ala  Pro Gly Val Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu 
    1100                 1105                 1110             


Val Leu  Glu Thr Ala Ala Pro  Gly Val Glu Asp Ile  Ser Gly Leu 
    1115                 1120                 1125             


Pro Ser  Gly Glu Val Leu Glu  Thr Ala Ala Pro Gly  Val Glu Asp 
    1130                 1135                 1140             


Ile Ser  Gly Leu Pro Ser Gly  Glu Val Leu Glu Thr  Ala Ala Pro 
    1145                 1150                 1155             


Gly Val  Glu Asp Ile Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu 
    1160                 1165                 1170             


Thr Ala  Ala Pro Gly Val Glu  Asp Ile Ser Gly Leu  Pro Ser Gly 
    1175                 1180                 1185             


Glu Val  Leu Glu Thr Ala Ala  Pro Gly Val Glu Asp  Ile Ser Gly 
    1190                 1195                 1200             


Leu Pro  Ser Gly Glu Val Leu  Glu Thr Ala Ala Pro  Gly Val Glu 
    1205                 1210                 1215             


Asp Ile  Ser Gly Leu Pro Ser  Gly Glu Val Leu Glu  Thr Ala Ala 
    1220                 1225                 1230             


Pro Gly  Val Glu Asp Ile Ser  Gly Leu Pro Ser Gly  Glu Val Leu 
    1235                 1240                 1245             


Glu Thr  Ala Ala Pro Gly Val  Glu Asp Ile Ser Gly  Leu Pro Ser 
    1250                 1255                 1260             


Gly Glu  Val Leu Glu Thr Ala  Ala Pro Gly Val Glu  Asp Ile Ser 
    1265                 1270                 1275             


Gly Leu  Pro Ser Gly Glu Val  Leu Glu Thr Ala Ala  Pro Gly Val 
    1280                 1285                 1290             


Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu Val Leu  Glu Thr Ala 
    1295                 1300                 1305             


Ala Pro  Gly Val Glu Asp Ile  Ser Gly Leu Pro Ser  Gly Glu Val 
    1310                 1315                 1320             


Leu Glu  Thr Ala Ala Pro Gly  Val Glu Asp Ile Ser  Gly Leu Pro 
    1325                 1330                 1335             


Ser Gly  Glu Val Leu Glu Thr  Ala Ala Pro Gly Val  Glu Asp Ile 
    1340                 1345                 1350             


Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu Thr Ala  Ala Pro Gly 
    1355                 1360                 1365             


Val Glu  Asp Ile Ser Gly Leu  Pro Ser Gly Glu Val  Leu Glu Thr 
    1370                 1375                 1380             


Ala Ala  Pro Gly Val Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu 
    1385                 1390                 1395             


Val Leu  Glu Thr Thr Ala Pro  Gly Val Glu Glu Ile  Ser Gly Leu 
    1400                 1405                 1410             


Pro Ser  Gly Glu Val Leu Glu  Thr Thr Ala Pro Gly  Val Asp Glu 
    1415                 1420                 1425             


Ile Ser  Gly Leu Pro Ser Gly  Glu Val Leu Glu Thr  Thr Ala Pro 
    1430                 1435                 1440             


Gly Val  Glu Glu Ile Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu 
    1445                 1450                 1455             


Thr Ser  Thr Ser Ala Val Gly  Asp Leu Ser Gly Leu  Pro Ser Gly 
    1460                 1465                 1470             


Gly Glu  Val Leu Glu Ile Ser  Val Ser Gly Val Glu  Asp Ile Ser 
    1475                 1480                 1485             


Gly Leu  Pro Ser Gly Glu Val  Val Glu Thr Ser Ala  Ser Gly Ile 
    1490                 1495                 1500             


Glu Asp  Val Ser Glu Leu Pro  Ser Gly Glu Gly Leu  Glu Thr Ser 
    1505                 1510                 1515             


Ala Ser  Gly Val Glu Asp Leu  Ser Arg Leu Pro Ser  Gly Glu Glu 
    1520                 1525                 1530             


Val Leu  Glu Ile Ser Ala Ser  Gly Phe Gly Asp Leu  Ser Gly Leu 
    1535                 1540                 1545             


Pro Ser  Gly Gly Glu Gly Leu  Glu Thr Ser Ala Ser  Glu Val Gly 
    1550                 1555                 1560             


Thr Asp  Leu Ser Gly Leu Pro  Ser Gly Arg Glu Gly  Leu Glu Thr 
    1565                 1570                 1575             


Ser Ala  Ser Gly Ala Glu Asp  Leu Ser Gly Leu Pro  Ser Gly Lys 
    1580                 1585                 1590             


Glu Asp  Leu Val Gly Ser Ala  Ser Gly Asp Leu Asp  Leu Gly Lys 
    1595                 1600                 1605             


Leu Pro  Ser Gly Thr Leu Gly  Ser Gly Gln Ala Pro  Glu Thr Ser 
    1610                 1615                 1620             


Gly Leu  Pro Ser Gly Phe Ser  Gly Glu Tyr Ser Gly  Val Asp Leu 
    1625                 1630                 1635             


Gly Ser  Gly Pro Pro Ser Gly  Leu Pro Asp Phe Ser  Gly Leu Pro 
    1640                 1645                 1650             


Ser Gly  Phe Pro Thr Val Ser  Leu Val Asp Ser Thr  Leu Val Glu 
    1655                 1660                 1665             


Val Val  Thr Ala Ser Thr Ala  Ser Glu Leu Glu Gly  Arg Gly Thr 
    1670                 1675                 1680             


Ile Gly  Ile Ser Gly Ala Gly  Glu Ile Ser Gly Leu  Pro Ser Ser 
    1685                 1690                 1695             


Glu Leu  Asp Ile Ser Gly Arg  Ala Ser Gly Leu Pro  Ser Gly Thr 
    1700                 1705                 1710             


Glu Leu  Ser Gly Gln Ala Ser  Gly Ser Pro Asp Val  Ser Gly Glu 
    1715                 1720                 1725             


Ile Pro  Gly Leu Phe Gly Val  Ser Gly Gln Pro Ser  Gly Phe Pro 
    1730                 1735                 1740             


Asp Thr  Ser Gly Glu Thr Ser  Gly Val Thr Glu Leu  Ser Gly Leu 
    1745                 1750                 1755             


Ser Ser  Gly Gln Pro Gly Ile  Ser Gly Glu Ala Ser  Gly Val Leu 
    1760                 1765                 1770             


Tyr Gly  Thr Ser Gln Pro Phe  Gly Ile Thr Asp Leu  Ser Gly Glu 
    1775                 1780                 1785             


Thr Ser  Gly Val Pro Asp Leu  Ser Gly Gln Pro Ser  Gly Leu Pro 
    1790                 1795                 1800             


Gly Phe  Ser Gly Ala Thr Ser  Gly Val Pro Asp Leu  Val Ser Gly 
    1805                 1810                 1815             


Thr Thr  Ser Gly Ser Gly Glu  Ser Ser Gly Ile Thr  Phe Val Asp 
    1820                 1825                 1830             


Thr Ser  Leu Val Glu Val Ala  Pro Thr Thr Phe Lys  Glu Glu Glu 
    1835                 1840                 1845             


Gly Leu  Gly Ser Val Glu Leu  Ser Gly Leu Pro Ser  Gly Glu Ala 
    1850                 1855                 1860             


Asp Leu  Ser Gly Lys Ser Gly  Met Val Asp Val Ser  Gly Gln Phe 
    1865                 1870                 1875             


Ser Gly  Thr Val Asp Ser Ser  Gly Phe Thr Ser Gln  Thr Pro Glu 
    1880                 1885                 1890             


Phe Ser  Gly Leu Pro Ser Gly  Ile Ala Glu Val Ser  Gly Glu Ser 
    1895                 1900                 1905             


Ser Arg  Ala Glu Ile Gly Ser  Ser Leu Pro Ser Gly  Ala Tyr Tyr 
    1910                 1915                 1920             


Gly Ser  Gly Thr Pro Ser Ser  Phe Pro Thr Val Ser  Leu Val Asp 
    1925                 1930                 1935             


Arg Thr  Leu Val Glu Ser Val  Thr Gln Ala Pro Thr  Ala Gln Glu 
    1940                 1945                 1950             


Ala Gly  Glu Gly Pro Ser Gly  Ile Leu Glu Leu Ser  Gly Ala His 
    1955                 1960                 1965             


Ser Gly  Ala Pro Asp Met Ser  Gly Glu His Ser Gly  Phe Leu Asp 
    1970                 1975                 1980             


Leu Ser  Gly Leu Gln Ser Gly  Leu Ile Glu Pro Ser  Gly Glu Pro 
    1985                 1990                 1995             


Pro Gly  Thr Pro Tyr Phe Ser  Gly Asp Phe Ala Ser  Thr Thr Asn 
    2000                 2005                 2010             


Val Ser  Gly Glu Ser Ser Val  Ala Met Gly Thr Ser  Gly Glu Ala 
    2015                 2020                 2025             


Ser Gly  Leu Pro Glu Val Thr  Leu Ile Thr Ser Glu  Phe Val Glu 
    2030                 2035                 2040             


Gly Val  Thr Glu Pro Thr Ile  Ser Gln Glu Leu Gly  Gln Arg Pro 
    2045                 2050                 2055             


Pro Val  Thr His Thr Pro Gln  Leu Phe Glu Ser Ser  Gly Lys Val 
    2060                 2065                 2070             


Ser Thr  Ala Gly Asp Ile Ser  Gly Ala Thr Pro Val  Leu Pro Gly 
    2075                 2080                 2085             


Ser Gly  Val Glu Val Ser Ser  Val Pro Glu Ser Ser  Ser Glu Thr 
    2090                 2095                 2100             


Ser Ala  Tyr Pro Glu Ala Gly  Phe Gly Ala Ser Ala  Ala Pro Glu 
    2105                 2110                 2115             


Ala Ser  Arg Glu Asp Ser Gly  Ser Pro Asp Leu Ser  Glu Thr Thr 
    2120                 2125                 2130             


Ser Ala  Phe His Glu Ala Asn  Leu Glu Arg Ser Ser  Gly Leu Gly 
    2135                 2140                 2145             


Val Ser  Gly Ser Thr Leu Thr  Phe Gln Glu Gly Glu  Ala Ser Ala 
    2150                 2155                 2160             


Ala Pro  Glu Val Ser Gly Glu  Ser Thr Thr Thr Ser  Asp Val Gly 
    2165                 2170                 2175             


Thr Glu  Ala Pro Gly Leu Pro  Ser Ala Thr Pro Thr  Ala Ser Gly 
    2180                 2185                 2190             


Asp Arg  Thr Glu Ile Ser Gly  Asp Leu Ser Gly His  Thr Ser Gln 
    2195                 2200                 2205             


Leu Gly  Val Val Ile Ser Thr  Ser Ile Pro Glu Ser  Glu Trp Thr 
    2210                 2215                 2220             


Gln Gln  Thr Gln Arg Pro Ala  Glu Thr His Leu Glu  Ile Glu Ser 
    2225                 2230                 2235             


Ser Ser  Leu Leu Tyr Ser Gly  Glu Glu Thr His Thr  Val Glu Thr 
    2240                 2245                 2250             


Ala Thr  Ser Pro Thr Asp Ala  Ser Ile Pro Ala Ser  Pro Glu Trp 
    2255                 2260                 2265             


Lys Arg  Glu Ser Glu Ser Thr  Ala Ala Ala Pro Ala  Arg Ser Cys 
    2270                 2275                 2280             


Ala Glu  Glu Pro Cys Gly Ala  Gly Thr Cys Lys Glu  Thr Glu Gly 
    2285                 2290                 2295             


His Val  Ile Cys Leu Cys Pro  Pro Gly Tyr Thr Gly  Glu His Cys 
    2300                 2305                 2310             


Asn Ile  Asp Gln Glu Val Cys  Glu Glu Gly Trp Asn  Lys Tyr Gln 
    2315                 2320                 2325             


Gly His  Cys Tyr Arg His Phe  Pro Asp Arg Glu Thr  Trp Val Asp 
    2330                 2335                 2340             


Ala Glu  Arg Arg Cys Arg Glu  Gln Gln Ser His Leu  Ser Ser Ile 
    2345                 2350                 2355             


Val Thr  Pro Glu Glu Gln Glu  Phe Val Asn Asn Asn  Ala Gln Asp 
    2360                 2365                 2370             


Tyr Gln  Trp Ile Gly Leu Asn  Asp Arg Thr Ile Glu  Gly Asp Phe 
    2375                 2380                 2385             


Arg Trp  Ser Asp Gly His Pro  Met Gln Phe Glu Asn  Trp Arg Pro 
    2390                 2395                 2400             


Asn Gln  Pro Asp Asn Phe Phe  Ala Ala Gly Glu Asp  Cys Val Val 
    2405                 2410                 2415             


Met Ile  Trp His Glu Lys Gly  Glu Trp Asn Asp Val  Pro Cys Asn 
    2420                 2425                 2430             


Tyr His  Leu Pro Phe Thr Cys  Lys Lys Gly Thr Val  Ala Cys Gly 
    2435                 2440                 2445             


Glu Pro  Pro Val Val Glu His  Ala Arg Thr Phe Gly  Gln Lys Lys 
    2450                 2455                 2460             


Asp Arg  Tyr Glu Ile Asn Ser  Leu Val Arg Tyr Gln  Cys Thr Glu 
    2465                 2470                 2475             


Gly Phe  Val Gln Arg His Met  Pro Thr Ile Arg Cys  Gln Pro Ser 
    2480                 2485                 2490             


Gly His  Trp Glu Glu Pro Gln  Ile Thr Cys Thr Asp  Pro Thr Thr 
    2495                 2500                 2505             


Tyr Lys  Arg Arg Leu Gln Lys  Arg Ser Ser Arg His  Pro Arg Arg 
    2510                 2515                 2520             


Ser Arg  Pro Ser Thr Ala His  
    2525                 2530 


<210>  106
<211>  2568
<212>  PRT
<213>  Homo Sapiens

<400>  106

Met Thr Thr Leu Leu Trp Val Phe Val Thr Leu Arg Val Ile Thr Ala 
1               5                   10                  15      


Ala Val Thr Val Glu Thr Ser Asp His Asp Asn Ser Leu Ser Val Ser 
            20                  25                  30          


Ile Pro Gln Pro Ser Pro Leu Arg Val Leu Leu Gly Thr Ser Leu Thr 
        35                  40                  45              


Ile Pro Cys Tyr Phe Ile Asp Pro Met His Pro Val Thr Thr Ala Pro 
    50                  55                  60                  


Ser Thr Ala Pro Leu Ala Pro Arg Ile Lys Trp Ser Arg Val Ser Lys 
65                  70                  75                  80  


Glu Lys Glu Val Val Leu Leu Val Ala Thr Glu Gly Arg Val Arg Val 
                85                  90                  95      


Asn Ser Ala Tyr Gln Asp Lys Val Ser Leu Pro Asn Tyr Pro Ala Ile 
            100                 105                 110         


Pro Ser Asp Ala Thr Leu Glu Val Gln Ser Leu Arg Ser Asn Asp Ser 
        115                 120                 125             


Gly Val Tyr Arg Cys Glu Val Met His Gly Ile Glu Asp Ser Glu Ala 
    130                 135                 140                 


Thr Leu Glu Val Val Val Lys Gly Ile Val Phe His Tyr Arg Ala Ile 
145                 150                 155                 160 


Ser Thr Arg Tyr Thr Leu Asp Phe Asp Arg Ala Gln Arg Ala Cys Leu 
                165                 170                 175     


Gln Asn Ser Ala Ile Ile Ala Thr Pro Glu Gln Leu Gln Ala Ala Tyr 
            180                 185                 190         


Glu Asp Gly Phe His Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr 
        195                 200                 205             


Val Arg Tyr Pro Ile His Thr Pro Arg Glu Gly Cys Tyr Gly Asp Lys 
    210                 215                 220                 


Asp Glu Phe Pro Gly Val Arg Thr Tyr Gly Ile Arg Asp Thr Asn Glu 
225                 230                 235                 240 


Thr Tyr Asp Val Tyr Cys Phe Ala Glu Glu Met Glu Gly Glu Val Phe 
                245                 250                 255     


Tyr Ala Thr Ser Pro Glu Lys Phe Thr Phe Gln Glu Ala Ala Asn Glu 
            260                 265                 270         


Cys Arg Arg Leu Gly Ala Arg Leu Ala Thr Thr Gly Gln Leu Tyr Leu 
        275                 280                 285             


Ala Trp Gln Ala Gly Met Asp Met Cys Ser Ala Gly Trp Leu Ala Asp 
    290                 295                 300                 


Arg Ser Val Arg Tyr Pro Ile Ser Lys Ala Arg Pro Asn Cys Gly Gly 
305                 310                 315                 320 


Asn Leu Leu Gly Val Arg Thr Val Tyr Val His Ala Asn Gln Thr Gly 
                325                 330                 335     


Tyr Pro Asp Pro Ser Ser Arg Tyr Asp Ala Ile Cys Tyr Thr Gly Glu 
            340                 345                 350         


Asp Phe Val Asp Ile Pro Glu Asn Phe Phe Gly Val Gly Gly Glu Glu 
        355                 360                 365             


Asp Ile Thr Val Gln Thr Val Thr Trp Pro Asp Met Glu Leu Pro Leu 
    370                 375                 380                 


Pro Arg Asn Ile Thr Glu Gly Glu Ala Arg Gly Ser Val Ile Leu Thr 
385                 390                 395                 400 


Val Lys Pro Ile Phe Glu Val Ser Pro Ser Pro Leu Glu Pro Glu Glu 
                405                 410                 415     


Pro Phe Thr Phe Ala Pro Glu Ile Gly Ala Thr Ala Phe Ala Glu Val 
            420                 425                 430         


Glu Asn Glu Thr Gly Glu Ala Thr Arg Pro Trp Gly Phe Pro Thr Pro 
        435                 440                 445             


Gly Leu Gly Pro Ala Thr Ala Phe Thr Ser Glu Asp Leu Val Val Gln 
    450                 455                 460                 


Val Thr Ala Val Pro Gly Gln Pro His Leu Pro Gly Gly Val Val Phe 
465                 470                 475                 480 


His Tyr Arg Pro Gly Pro Thr Arg Tyr Ser Leu Thr Phe Glu Glu Ala 
                485                 490                 495     


Gln Gln Ala Cys Leu Arg Thr Gly Ala Val Ile Ala Ser Pro Glu Gln 
            500                 505                 510         


Leu Gln Ala Ala Tyr Glu Ala Gly Tyr Glu Gln Cys Asp Ala Gly Trp 
        515                 520                 525             


Leu Arg Asp Gln Thr Val Arg Tyr Pro Ile Val Ser Pro Arg Thr Pro 
    530                 535                 540                 


Cys Val Gly Asp Lys Asp Ser Ser Pro Gly Val Arg Thr Tyr Gly Val 
545                 550                 555                 560 


Arg Pro Ser Thr Glu Thr Tyr Asp Val Tyr Cys Phe Val Asp Arg Leu 
                565                 570                 575     


Glu Gly Glu Val Phe Phe Ala Thr Arg Leu Glu Gln Phe Thr Phe Gln 
            580                 585                 590         


Glu Ala Leu Glu Phe Cys Glu Ser His Asn Ala Thr Leu Ala Thr Thr 
        595                 600                 605             


Gly Gln Leu Tyr Ala Ala Trp Ser Arg Gly Leu Asp Lys Cys Tyr Ala 
    610                 615                 620                 


Gly Trp Leu Ala Asp Gly Ser Leu Arg Tyr Pro Ile Val Thr Pro Arg 
625                 630                 635                 640 


Pro Ala Cys Gly Gly Asp Lys Pro Gly Val Arg Thr Val Tyr Leu Tyr 
                645                 650                 655     


Pro Asn Gln Thr Gly Leu Pro Asp Pro Leu Ser Arg His His Ala Phe 
            660                 665                 670         


Cys Phe Arg Gly Ile Ser Ala Val Pro Ser Pro Gly Glu Glu Glu Gly 
        675                 680                 685             


Gly Thr Pro Thr Ser Pro Ser Gly Val Glu Glu Trp Ile Val Thr Gln 
    690                 695                 700                 


Val Val Pro Gly Val Ala Ala Val Pro Val Glu Glu Glu Thr Thr Ala 
705                 710                 715                 720 


Val Pro Ser Gly Glu Thr Thr Ala Ile Leu Glu Phe Thr Thr Glu Pro 
                725                 730                 735     


Glu Asn Gln Thr Glu Trp Glu Pro Ala Tyr Thr Pro Val Gly Thr Ser 
            740                 745                 750         


Pro Leu Pro Gly Ile Leu Pro Thr Trp Pro Pro Thr Gly Ala Ala Thr 
        755                 760                 765             


Glu Glu Ser Thr Glu Gly Pro Ser Ala Thr Glu Val Pro Ser Ala Ser 
    770                 775                 780                 


Glu Glu Pro Ser Pro Ser Glu Val Pro Phe Pro Ser Glu Glu Pro Ser 
785                 790                 795                 800 


Pro Ser Glu Glu Pro Phe Pro Ser Val Arg Pro Phe Pro Ser Val Glu 
                805                 810                 815     


Leu Phe Pro Ser Glu Glu Pro Phe Pro Ser Lys Glu Pro Ser Pro Ser 
            820                 825                 830         


Glu Glu Pro Ser Ala Ser Glu Glu Pro Tyr Thr Pro Ser Pro Pro Val 
        835                 840                 845             


Pro Ser Trp Thr Glu Leu Pro Ser Ser Gly Glu Glu Ser Gly Ala Pro 
    850                 855                 860                 


Asp Val Ser Gly Asp Phe Thr Gly Ser Gly Asp Val Ser Gly His Leu 
865                 870                 875                 880 


Asp Phe Ser Gly Gln Leu Ser Gly Asp Arg Ala Ser Gly Leu Pro Ser 
                885                 890                 895     


Gly Asp Leu Asp Ser Ser Gly Leu Thr Ser Thr Val Gly Ser Gly Leu 
            900                 905                 910         


Pro Val Glu Ser Gly Leu Pro Ser Gly Asp Glu Glu Arg Ile Glu Trp 
        915                 920                 925             


Pro Ser Thr Pro Thr Val Gly Glu Leu Pro Ser Gly Ala Glu Ile Leu 
    930                 935                 940                 


Glu Gly Ser Ala Ser Gly Val Gly Asp Leu Ser Gly Leu Pro Ser Gly 
945                 950                 955                 960 


Glu Val Leu Glu Thr Ser Ala Ser Gly Val Gly Asp Leu Ser Gly Leu 
                965                 970                 975     


Pro Ser Gly Glu Val Leu Glu Thr Thr Ala Pro Gly Val Glu Asp Ile 
            980                 985                 990         


Ser Gly Leu Pro Ser Gly Glu Val  Leu Glu Thr Thr Ala  Pro Gly Val 
        995                 1000                 1005             


Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu Val Leu  Glu Thr Thr 
    1010                 1015                 1020             


Ala Pro  Gly Val Glu Asp Ile  Ser Gly Leu Pro Ser  Gly Glu Val 
    1025                 1030                 1035             


Leu Glu  Thr Thr Ala Pro Gly  Val Glu Asp Ile Ser  Gly Leu Pro 
    1040                 1045                 1050             


Ser Gly  Glu Val Leu Glu Thr  Thr Ala Pro Gly Val  Glu Asp Ile 
    1055                 1060                 1065             


Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu Thr Thr  Ala Pro Gly 
    1070                 1075                 1080             


Val Glu  Asp Ile Ser Gly Leu  Pro Ser Gly Glu Val  Leu Glu Thr 
    1085                 1090                 1095             


Ala Ala  Pro Gly Val Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu 
    1100                 1105                 1110             


Val Leu  Glu Thr Ala Ala Pro  Gly Val Glu Asp Ile  Ser Gly Leu 
    1115                 1120                 1125             


Pro Ser  Gly Glu Val Leu Glu  Thr Ala Ala Pro Gly  Val Glu Asp 
    1130                 1135                 1140             


Ile Ser  Gly Leu Pro Ser Gly  Glu Val Leu Glu Thr  Ala Ala Pro 
    1145                 1150                 1155             


Gly Val  Glu Asp Ile Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu 
    1160                 1165                 1170             


Thr Ala  Ala Pro Gly Val Glu  Asp Ile Ser Gly Leu  Pro Ser Gly 
    1175                 1180                 1185             


Glu Val  Leu Glu Thr Ala Ala  Pro Gly Val Glu Asp  Ile Ser Gly 
    1190                 1195                 1200             


Leu Pro  Ser Gly Glu Val Leu  Glu Thr Ala Ala Pro  Gly Val Glu 
    1205                 1210                 1215             


Asp Ile  Ser Gly Leu Pro Ser  Gly Glu Val Leu Glu  Thr Ala Ala 
    1220                 1225                 1230             


Pro Gly  Val Glu Asp Ile Ser  Gly Leu Pro Ser Gly  Glu Val Leu 
    1235                 1240                 1245             


Glu Thr  Ala Ala Pro Gly Val  Glu Asp Ile Ser Gly  Leu Pro Ser 
    1250                 1255                 1260             


Gly Glu  Val Leu Glu Thr Ala  Ala Pro Gly Val Glu  Asp Ile Ser 
    1265                 1270                 1275             


Gly Leu  Pro Ser Gly Glu Val  Leu Glu Thr Ala Ala  Pro Gly Val 
    1280                 1285                 1290             


Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu Val Leu  Glu Thr Ala 
    1295                 1300                 1305             


Ala Pro  Gly Val Glu Asp Ile  Ser Gly Leu Pro Ser  Gly Glu Val 
    1310                 1315                 1320             


Leu Glu  Thr Ala Ala Pro Gly  Val Glu Asp Ile Ser  Gly Leu Pro 
    1325                 1330                 1335             


Ser Gly  Glu Val Leu Glu Thr  Ala Ala Pro Gly Val  Glu Asp Ile 
    1340                 1345                 1350             


Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu Thr Ala  Ala Pro Gly 
    1355                 1360                 1365             


Val Glu  Asp Ile Ser Gly Leu  Pro Ser Gly Glu Val  Leu Glu Thr 
    1370                 1375                 1380             


Ala Ala  Pro Gly Val Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu 
    1385                 1390                 1395             


Val Leu  Glu Thr Thr Ala Pro  Gly Val Glu Glu Ile  Ser Gly Leu 
    1400                 1405                 1410             


Pro Ser  Gly Glu Val Leu Glu  Thr Thr Ala Pro Gly  Val Asp Glu 
    1415                 1420                 1425             


Ile Ser  Gly Leu Pro Ser Gly  Glu Val Leu Glu Thr  Thr Ala Pro 
    1430                 1435                 1440             


Gly Val  Glu Glu Ile Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu 
    1445                 1450                 1455             


Thr Ser  Thr Ser Ala Val Gly  Asp Leu Ser Gly Leu  Pro Ser Gly 
    1460                 1465                 1470             


Gly Glu  Val Leu Glu Ile Ser  Val Ser Gly Val Glu  Asp Ile Ser 
    1475                 1480                 1485             


Gly Leu  Pro Ser Gly Glu Val  Val Glu Thr Ser Ala  Ser Gly Ile 
    1490                 1495                 1500             


Glu Asp  Val Ser Glu Leu Pro  Ser Gly Glu Gly Leu  Glu Thr Ser 
    1505                 1510                 1515             


Ala Ser  Gly Val Glu Asp Leu  Ser Arg Leu Pro Ser  Gly Glu Glu 
    1520                 1525                 1530             


Val Leu  Glu Ile Ser Ala Ser  Gly Phe Gly Asp Leu  Ser Gly Leu 
    1535                 1540                 1545             


Pro Ser  Gly Gly Glu Gly Leu  Glu Thr Ser Ala Ser  Glu Val Gly 
    1550                 1555                 1560             


Thr Asp  Leu Ser Gly Leu Pro  Ser Gly Arg Glu Gly  Leu Glu Thr 
    1565                 1570                 1575             


Ser Ala  Ser Gly Ala Glu Asp  Leu Ser Gly Leu Pro  Ser Gly Lys 
    1580                 1585                 1590             


Glu Asp  Leu Val Gly Ser Ala  Ser Gly Asp Leu Asp  Leu Gly Lys 
    1595                 1600                 1605             


Leu Pro  Ser Gly Thr Leu Gly  Ser Gly Gln Ala Pro  Glu Thr Ser 
    1610                 1615                 1620             


Gly Leu  Pro Ser Gly Phe Ser  Gly Glu Tyr Ser Gly  Val Asp Leu 
    1625                 1630                 1635             


Gly Ser  Gly Pro Pro Ser Gly  Leu Pro Asp Phe Ser  Gly Leu Pro 
    1640                 1645                 1650             


Ser Gly  Phe Pro Thr Val Ser  Leu Val Asp Ser Thr  Leu Val Glu 
    1655                 1660                 1665             


Val Val  Thr Ala Ser Thr Ala  Ser Glu Leu Glu Gly  Arg Gly Thr 
    1670                 1675                 1680             


Ile Gly  Ile Ser Gly Ala Gly  Glu Ile Ser Gly Leu  Pro Ser Ser 
    1685                 1690                 1695             


Glu Leu  Asp Ile Ser Gly Arg  Ala Ser Gly Leu Pro  Ser Gly Thr 
    1700                 1705                 1710             


Glu Leu  Ser Gly Gln Ala Ser  Gly Ser Pro Asp Val  Ser Gly Glu 
    1715                 1720                 1725             


Ile Pro  Gly Leu Phe Gly Val  Ser Gly Gln Pro Ser  Gly Phe Pro 
    1730                 1735                 1740             


Asp Thr  Ser Gly Glu Thr Ser  Gly Val Thr Glu Leu  Ser Gly Leu 
    1745                 1750                 1755             


Ser Ser  Gly Gln Pro Gly Ile  Ser Gly Glu Ala Ser  Gly Val Leu 
    1760                 1765                 1770             


Tyr Gly  Thr Ser Gln Pro Phe  Gly Ile Thr Asp Leu  Ser Gly Glu 
    1775                 1780                 1785             


Thr Ser  Gly Val Pro Asp Leu  Ser Gly Gln Pro Ser  Gly Leu Pro 
    1790                 1795                 1800             


Gly Phe  Ser Gly Ala Thr Ser  Gly Val Pro Asp Leu  Val Ser Gly 
    1805                 1810                 1815             


Thr Thr  Ser Gly Ser Gly Glu  Ser Ser Gly Ile Thr  Phe Val Asp 
    1820                 1825                 1830             


Thr Ser  Leu Val Glu Val Ala  Pro Thr Thr Phe Lys  Glu Glu Glu 
    1835                 1840                 1845             


Gly Leu  Gly Ser Val Glu Leu  Ser Gly Leu Pro Ser  Gly Glu Ala 
    1850                 1855                 1860             


Asp Leu  Ser Gly Lys Ser Gly  Met Val Asp Val Ser  Gly Gln Phe 
    1865                 1870                 1875             


Ser Gly  Thr Val Asp Ser Ser  Gly Phe Thr Ser Gln  Thr Pro Glu 
    1880                 1885                 1890             


Phe Ser  Gly Leu Pro Ser Gly  Ile Ala Glu Val Ser  Gly Glu Ser 
    1895                 1900                 1905             


Ser Arg  Ala Glu Ile Gly Ser  Ser Leu Pro Ser Gly  Ala Tyr Tyr 
    1910                 1915                 1920             


Gly Ser  Gly Thr Pro Ser Ser  Phe Pro Thr Val Ser  Leu Val Asp 
    1925                 1930                 1935             


Arg Thr  Leu Val Glu Ser Val  Thr Gln Ala Pro Thr  Ala Gln Glu 
    1940                 1945                 1950             


Ala Gly  Glu Gly Pro Ser Gly  Ile Leu Glu Leu Ser  Gly Ala His 
    1955                 1960                 1965             


Ser Gly  Ala Pro Asp Met Ser  Gly Glu His Ser Gly  Phe Leu Asp 
    1970                 1975                 1980             


Leu Ser  Gly Leu Gln Ser Gly  Leu Ile Glu Pro Ser  Gly Glu Pro 
    1985                 1990                 1995             


Pro Gly  Thr Pro Tyr Phe Ser  Gly Asp Phe Ala Ser  Thr Thr Asn 
    2000                 2005                 2010             


Val Ser  Gly Glu Ser Ser Val  Ala Met Gly Thr Ser  Gly Glu Ala 
    2015                 2020                 2025             


Ser Gly  Leu Pro Glu Val Thr  Leu Ile Thr Ser Glu  Phe Val Glu 
    2030                 2035                 2040             


Gly Val  Thr Glu Pro Thr Ile  Ser Gln Glu Leu Gly  Gln Arg Pro 
    2045                 2050                 2055             


Pro Val  Thr His Thr Pro Gln  Leu Phe Glu Ser Ser  Gly Lys Val 
    2060                 2065                 2070             


Ser Thr  Ala Gly Asp Ile Ser  Gly Ala Thr Pro Val  Leu Pro Gly 
    2075                 2080                 2085             


Ser Gly  Val Glu Val Ser Ser  Val Pro Glu Ser Ser  Ser Glu Thr 
    2090                 2095                 2100             


Ser Ala  Tyr Pro Glu Ala Gly  Phe Gly Ala Ser Ala  Ala Pro Glu 
    2105                 2110                 2115             


Ala Ser  Arg Glu Asp Ser Gly  Ser Pro Asp Leu Ser  Glu Thr Thr 
    2120                 2125                 2130             


Ser Ala  Phe His Glu Ala Asn  Leu Glu Arg Ser Ser  Gly Leu Gly 
    2135                 2140                 2145             


Val Ser  Gly Ser Thr Leu Thr  Phe Gln Glu Gly Glu  Ala Ser Ala 
    2150                 2155                 2160             


Ala Pro  Glu Val Ser Gly Glu  Ser Thr Thr Thr Ser  Asp Val Gly 
    2165                 2170                 2175             


Thr Glu  Ala Pro Gly Leu Pro  Ser Ala Thr Pro Thr  Ala Ser Gly 
    2180                 2185                 2190             


Asp Arg  Thr Glu Ile Ser Gly  Asp Leu Ser Gly His  Thr Ser Gln 
    2195                 2200                 2205             


Leu Gly  Val Val Ile Ser Thr  Ser Ile Pro Glu Ser  Glu Trp Thr 
    2210                 2215                 2220             


Gln Gln  Thr Gln Arg Pro Ala  Glu Thr His Leu Glu  Ile Glu Ser 
    2225                 2230                 2235             


Ser Ser  Leu Leu Tyr Ser Gly  Glu Glu Thr His Thr  Val Glu Thr 
    2240                 2245                 2250             


Ala Thr  Ser Pro Thr Asp Ala  Ser Ile Pro Ala Ser  Pro Glu Trp 
    2255                 2260                 2265             


Lys Arg  Glu Ser Glu Ser Thr  Ala Ala Ala Pro Ala  Arg Ser Cys 
    2270                 2275                 2280             


Ala Glu  Glu Pro Cys Gly Ala  Gly Thr Cys Lys Glu  Thr Glu Gly 
    2285                 2290                 2295             


His Val  Ile Cys Leu Cys Pro  Pro Gly Tyr Thr Gly  Glu His Cys 
    2300                 2305                 2310             


Asn Ile  Asp Ile Asp Glu Cys  Leu Ser Ser Pro Cys  Leu Asn Gly 
    2315                 2320                 2325             


Ala Thr  Cys Val Asp Ala Ile  Asp Ser Phe Thr Cys  Leu Cys Leu 
    2330                 2335                 2340             


Pro Ser  Tyr Glu Gly Asp Leu  Cys Glu Ile Asp Gln  Glu Val Cys 
    2345                 2350                 2355             


Glu Glu  Gly Trp Asn Lys Tyr  Gln Gly His Cys Tyr  Arg His Phe 
    2360                 2365                 2370             


Pro Asp  Arg Glu Thr Trp Val  Asp Ala Glu Arg Arg  Cys Arg Glu 
    2375                 2380                 2385             


Gln Gln  Ser His Leu Ser Ser  Ile Val Thr Pro Glu  Glu Gln Glu 
    2390                 2395                 2400             


Phe Val  Asn Asn Asn Ala Gln  Asp Tyr Gln Trp Ile  Gly Leu Asn 
    2405                 2410                 2415             


Asp Arg  Thr Ile Glu Gly Asp  Phe Arg Trp Ser Asp  Gly His Pro 
    2420                 2425                 2430             


Met Gln  Phe Glu Asn Trp Arg  Pro Asn Gln Pro Asp  Asn Phe Phe 
    2435                 2440                 2445             


Ala Ala  Gly Glu Asp Cys Val  Val Met Ile Trp His  Glu Lys Gly 
    2450                 2455                 2460             


Glu Trp  Asn Asp Val Pro Cys  Asn Tyr His Leu Pro  Phe Thr Cys 
    2465                 2470                 2475             


Lys Lys  Gly Thr Val Ala Cys  Gly Glu Pro Pro Val  Val Glu His 
    2480                 2485                 2490             


Ala Arg  Thr Phe Gly Gln Lys  Lys Asp Arg Tyr Glu  Ile Asn Ser 
    2495                 2500                 2505             


Leu Val  Arg Tyr Gln Cys Thr  Glu Gly Phe Val Gln  Arg His Met 
    2510                 2515                 2520             


Pro Thr  Ile Arg Cys Gln Pro  Ser Gly His Trp Glu  Glu Pro Gln 
    2525                 2530                 2535             


Ile Thr  Cys Thr Asp Pro Thr  Thr Tyr Lys Arg Arg  Leu Gln Lys 
    2540                 2545                 2550             


Arg Ser  Ser Arg His Pro Arg  Arg Ser Arg Pro Ser  Thr Ala His 
    2555                 2560                 2565             


<210>  107
<211>  2473
<212>  PRT
<213>  Homo Sapiens

<400>  107

Met Thr Thr Leu Leu Trp Val Phe Val Thr Leu Arg Val Ile Thr Ala 
1               5                   10                  15      


Ala Val Thr Val Glu Thr Ser Asp His Asp Asn Ser Leu Ser Val Ser 
            20                  25                  30          


Ile Pro Gln Pro Ser Pro Leu Arg Val Leu Leu Gly Thr Ser Leu Thr 
        35                  40                  45              


Ile Pro Cys Tyr Phe Ile Asp Pro Met His Pro Val Thr Thr Ala Pro 
    50                  55                  60                  


Ser Thr Ala Pro Leu Ala Pro Arg Ile Lys Trp Ser Arg Val Ser Lys 
65                  70                  75                  80  


Glu Lys Glu Val Val Leu Leu Val Ala Thr Glu Gly Arg Val Arg Val 
                85                  90                  95      


Asn Ser Ala Tyr Gln Asp Lys Val Ser Leu Pro Asn Tyr Pro Ala Ile 
            100                 105                 110         


Pro Ser Asp Ala Thr Leu Glu Val Gln Ser Leu Arg Ser Asn Asp Ser 
        115                 120                 125             


Gly Val Tyr Arg Cys Glu Val Met His Gly Ile Glu Asp Ser Glu Ala 
    130                 135                 140                 


Thr Leu Glu Val Val Val Lys Gly Ile Val Phe His Tyr Arg Ala Ile 
145                 150                 155                 160 


Ser Thr Arg Tyr Thr Leu Asp Phe Asp Arg Ala Gln Arg Ala Cys Leu 
                165                 170                 175     


Gln Asn Ser Ala Ile Ile Ala Thr Pro Glu Gln Leu Gln Ala Ala Tyr 
            180                 185                 190         


Glu Asp Gly Phe His Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr 
        195                 200                 205             


Val Arg Tyr Pro Ile His Thr Pro Arg Glu Gly Cys Tyr Gly Asp Lys 
    210                 215                 220                 


Asp Glu Phe Pro Gly Val Arg Thr Tyr Gly Ile Arg Asp Thr Asn Glu 
225                 230                 235                 240 


Thr Tyr Asp Val Tyr Cys Phe Ala Glu Glu Met Glu Gly Glu Val Phe 
                245                 250                 255     


Tyr Ala Thr Ser Pro Glu Lys Phe Thr Phe Gln Glu Ala Ala Asn Glu 
            260                 265                 270         


Cys Arg Arg Leu Gly Ala Arg Leu Ala Thr Thr Gly Gln Leu Tyr Leu 
        275                 280                 285             


Ala Trp Gln Ala Gly Met Asp Met Cys Ser Ala Gly Trp Leu Ala Asp 
    290                 295                 300                 


Arg Ser Val Arg Tyr Pro Ile Ser Lys Ala Arg Pro Asn Cys Gly Gly 
305                 310                 315                 320 


Asn Leu Leu Gly Val Arg Thr Val Tyr Val His Ala Asn Gln Thr Gly 
                325                 330                 335     


Tyr Pro Asp Pro Ser Ser Arg Tyr Asp Ala Ile Cys Tyr Thr Gly Glu 
            340                 345                 350         


Asp Phe Val Asp Ile Pro Glu Asn Phe Phe Gly Val Gly Gly Glu Glu 
        355                 360                 365             


Asp Ile Thr Val Gln Thr Val Thr Trp Pro Asp Met Glu Leu Pro Leu 
    370                 375                 380                 


Pro Arg Asn Ile Thr Glu Gly Glu Ala Arg Gly Ser Val Ile Leu Thr 
385                 390                 395                 400 


Val Lys Pro Ile Phe Glu Val Ser Pro Ser Pro Leu Glu Pro Glu Glu 
                405                 410                 415     


Pro Phe Thr Phe Ala Pro Glu Ile Gly Ala Thr Ala Phe Ala Glu Val 
            420                 425                 430         


Glu Asn Glu Thr Gly Glu Ala Thr Arg Pro Trp Gly Phe Pro Thr Pro 
        435                 440                 445             


Gly Leu Gly Pro Ala Thr Ala Phe Thr Ser Glu Asp Leu Val Val Gln 
    450                 455                 460                 


Val Thr Ala Val Pro Gly Gln Pro His Leu Pro Gly Gly Val Val Phe 
465                 470                 475                 480 


His Tyr Arg Pro Gly Pro Thr Arg Tyr Ser Leu Thr Phe Glu Glu Ala 
                485                 490                 495     


Gln Gln Ala Cys Leu Arg Thr Gly Ala Val Ile Ala Ser Pro Glu Gln 
            500                 505                 510         


Leu Gln Ala Ala Tyr Glu Ala Gly Tyr Glu Gln Cys Asp Ala Gly Trp 
        515                 520                 525             


Leu Arg Asp Gln Thr Val Arg Tyr Pro Ile Val Ser Pro Arg Thr Pro 
    530                 535                 540                 


Cys Val Gly Asp Lys Asp Ser Ser Pro Gly Val Arg Thr Tyr Gly Val 
545                 550                 555                 560 


Arg Pro Ser Thr Glu Thr Tyr Asp Val Tyr Cys Phe Val Asp Arg Leu 
                565                 570                 575     


Glu Gly Glu Val Phe Phe Ala Thr Arg Leu Glu Gln Phe Thr Phe Gln 
            580                 585                 590         


Glu Ala Leu Glu Phe Cys Glu Ser His Asn Ala Thr Leu Ala Thr Thr 
        595                 600                 605             


Gly Gln Leu Tyr Ala Ala Trp Ser Arg Gly Leu Asp Lys Cys Tyr Ala 
    610                 615                 620                 


Gly Trp Leu Ala Asp Gly Ser Leu Arg Tyr Pro Ile Val Thr Pro Arg 
625                 630                 635                 640 


Pro Ala Cys Gly Gly Asp Lys Pro Gly Val Arg Thr Val Tyr Leu Tyr 
                645                 650                 655     


Pro Asn Gln Thr Gly Leu Pro Asp Pro Leu Ser Arg His His Ala Phe 
            660                 665                 670         


Cys Phe Arg Gly Ile Ser Ala Val Pro Ser Pro Gly Glu Glu Glu Gly 
        675                 680                 685             


Gly Thr Pro Thr Ser Pro Ser Gly Val Glu Glu Trp Ile Val Thr Gln 
    690                 695                 700                 


Val Val Pro Gly Val Ala Ala Val Pro Val Glu Glu Glu Thr Thr Ala 
705                 710                 715                 720 


Val Pro Ser Gly Glu Thr Thr Ala Ile Leu Glu Phe Thr Thr Glu Pro 
                725                 730                 735     


Glu Asn Gln Thr Glu Trp Glu Pro Ala Tyr Thr Pro Val Gly Thr Ser 
            740                 745                 750         


Pro Leu Pro Gly Ile Leu Pro Thr Trp Pro Pro Thr Gly Ala Ala Thr 
        755                 760                 765             


Glu Glu Ser Thr Glu Gly Pro Ser Ala Thr Glu Val Pro Ser Ala Ser 
    770                 775                 780                 


Glu Glu Pro Ser Pro Ser Glu Val Pro Phe Pro Ser Glu Glu Pro Ser 
785                 790                 795                 800 


Pro Ser Glu Glu Pro Phe Pro Ser Val Arg Pro Phe Pro Ser Val Glu 
                805                 810                 815     


Leu Phe Pro Ser Glu Glu Pro Phe Pro Ser Lys Glu Pro Ser Pro Ser 
            820                 825                 830         


Glu Glu Pro Ser Ala Ser Glu Glu Pro Tyr Thr Pro Ser Pro Pro Val 
        835                 840                 845             


Pro Ser Trp Thr Glu Leu Pro Ser Ser Gly Glu Glu Ser Gly Ala Pro 
    850                 855                 860                 


Asp Val Ser Gly Asp Phe Thr Gly Ser Gly Asp Val Ser Gly His Leu 
865                 870                 875                 880 


Asp Phe Ser Gly Gln Leu Ser Gly Asp Arg Ala Ser Gly Leu Pro Ser 
                885                 890                 895     


Gly Asp Leu Asp Ser Ser Gly Leu Thr Ser Thr Val Gly Ser Gly Leu 
            900                 905                 910         


Pro Val Glu Ser Gly Leu Pro Ser Gly Asp Glu Glu Arg Ile Glu Trp 
        915                 920                 925             


Pro Ser Thr Pro Thr Val Gly Glu Leu Pro Ser Gly Ala Glu Ile Leu 
    930                 935                 940                 


Glu Gly Ser Ala Ser Gly Val Gly Asp Leu Ser Gly Leu Pro Ser Gly 
945                 950                 955                 960 


Glu Val Leu Glu Thr Ser Ala Ser Gly Val Gly Asp Leu Ser Gly Leu 
                965                 970                 975     


Pro Ser Gly Glu Val Leu Glu Thr Thr Ala Pro Gly Val Glu Asp Ile 
            980                 985                 990         


Ser Gly Leu Pro Ser Gly Glu Val  Leu Glu Thr Thr Ala  Pro Gly Val 
        995                 1000                 1005             


Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu Val Leu  Glu Thr Thr 
    1010                 1015                 1020             


Ala Pro  Gly Val Glu Asp Ile  Ser Gly Leu Pro Ser  Gly Glu Val 
    1025                 1030                 1035             


Leu Glu  Thr Thr Ala Pro Gly  Val Glu Asp Ile Ser  Gly Leu Pro 
    1040                 1045                 1050             


Ser Gly  Glu Val Leu Glu Thr  Thr Ala Pro Gly Val  Glu Asp Ile 
    1055                 1060                 1065             


Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu Thr Ala  Ala Pro Gly 
    1070                 1075                 1080             


Val Glu  Asp Ile Ser Gly Leu  Pro Ser Gly Glu Val  Leu Glu Thr 
    1085                 1090                 1095             


Ala Ala  Pro Gly Val Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu 
    1100                 1105                 1110             


Val Leu  Glu Thr Ala Ala Pro  Gly Val Glu Asp Ile  Ser Gly Leu 
    1115                 1120                 1125             


Pro Ser  Gly Glu Val Leu Glu  Thr Ala Ala Pro Gly  Val Glu Asp 
    1130                 1135                 1140             


Ile Ser  Gly Leu Pro Ser Gly  Glu Val Leu Glu Thr  Ala Ala Pro 
    1145                 1150                 1155             


Gly Val  Glu Asp Ile Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu 
    1160                 1165                 1170             


Thr Ala  Ala Pro Gly Val Glu  Asp Ile Ser Gly Leu  Pro Ser Gly 
    1175                 1180                 1185             


Glu Val  Leu Glu Thr Ala Ala  Pro Gly Val Glu Asp  Ile Ser Gly 
    1190                 1195                 1200             


Leu Pro  Ser Gly Glu Val Leu  Glu Thr Ala Ala Pro  Gly Val Glu 
    1205                 1210                 1215             


Asp Ile  Ser Gly Leu Pro Ser  Gly Glu Val Leu Glu  Thr Ala Ala 
    1220                 1225                 1230             


Pro Gly  Val Glu Asp Ile Ser  Gly Leu Pro Ser Gly  Glu Val Leu 
    1235                 1240                 1245             


Glu Thr  Ala Ala Pro Gly Val  Glu Asp Ile Ser Gly  Leu Pro Ser 
    1250                 1255                 1260             


Gly Glu  Val Leu Glu Thr Ala  Ala Pro Gly Val Glu  Asp Ile Ser 
    1265                 1270                 1275             


Gly Leu  Pro Ser Gly Glu Val  Leu Glu Thr Ala Ala  Pro Gly Val 
    1280                 1285                 1290             


Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu Val Leu  Glu Thr Ala 
    1295                 1300                 1305             


Ala Pro  Gly Val Glu Asp Ile  Ser Gly Leu Pro Ser  Gly Glu Val 
    1310                 1315                 1320             


Leu Glu  Thr Ala Ala Pro Gly  Val Glu Asp Ile Ser  Gly Leu Pro 
    1325                 1330                 1335             


Ser Gly  Glu Val Leu Glu Thr  Ala Ala Pro Gly Val  Glu Asp Ile 
    1340                 1345                 1350             


Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu Thr Ala  Ala Pro Gly 
    1355                 1360                 1365             


Val Glu  Asp Ile Ser Gly Leu  Pro Ser Gly Glu Val  Leu Glu Thr 
    1370                 1375                 1380             


Thr Ala  Pro Gly Val Glu Glu  Ile Ser Gly Leu Pro  Ser Gly Glu 
    1385                 1390                 1395             


Val Leu  Glu Thr Thr Ala Pro  Gly Val Asp Glu Ile  Ser Gly Leu 
    1400                 1405                 1410             


Pro Ser  Gly Glu Val Leu Glu  Thr Thr Ala Pro Gly  Val Glu Glu 
    1415                 1420                 1425             


Ile Ser  Gly Leu Pro Ser Gly  Glu Val Leu Glu Thr  Ser Thr Ser 
    1430                 1435                 1440             


Ala Val  Gly Asp Leu Ser Gly  Leu Pro Ser Gly Gly  Glu Val Leu 
    1445                 1450                 1455             


Glu Ile  Ser Val Ser Gly Val  Glu Asp Ile Ser Gly  Leu Pro Ser 
    1460                 1465                 1470             


Gly Glu  Val Val Glu Thr Ser  Ala Ser Gly Ile Glu  Asp Val Ser 
    1475                 1480                 1485             


Glu Leu  Pro Ser Gly Glu Gly  Leu Glu Thr Ser Ala  Ser Gly Val 
    1490                 1495                 1500             


Glu Asp  Leu Ser Arg Leu Pro  Ser Gly Glu Glu Val  Leu Glu Ile 
    1505                 1510                 1515             


Ser Ala  Ser Gly Phe Gly Asp  Leu Ser Gly Leu Pro  Ser Gly Gly 
    1520                 1525                 1530             


Glu Gly  Leu Glu Thr Ser Ala  Ser Glu Val Gly Thr  Asp Leu Ser 
    1535                 1540                 1545             


Gly Leu  Pro Ser Gly Arg Glu  Gly Leu Glu Thr Ser  Ala Ser Gly 
    1550                 1555                 1560             


Ala Glu  Asp Leu Ser Gly Leu  Pro Ser Gly Lys Glu  Asp Leu Val 
    1565                 1570                 1575             


Gly Ser  Ala Ser Gly Asp Leu  Asp Leu Gly Lys Leu  Pro Ser Gly 
    1580                 1585                 1590             


Thr Leu  Gly Ser Gly Gln Ala  Pro Glu Thr Ser Gly  Leu Pro Ser 
    1595                 1600                 1605             


Gly Phe  Ser Gly Glu Tyr Ser  Gly Val Asp Leu Gly  Ser Gly Pro 
    1610                 1615                 1620             


Pro Ser  Gly Leu Pro Asp Phe  Ser Gly Leu Pro Ser  Gly Phe Pro 
    1625                 1630                 1635             


Thr Val  Ser Leu Val Asp Ser  Thr Leu Val Glu Val  Val Thr Ala 
    1640                 1645                 1650             


Ser Thr  Ala Ser Glu Leu Glu  Gly Arg Gly Thr Ile  Gly Ile Ser 
    1655                 1660                 1665             


Gly Ala  Gly Glu Ile Ser Gly  Leu Pro Ser Ser Glu  Leu Asp Ile 
    1670                 1675                 1680             


Ser Gly  Arg Ala Ser Gly Leu  Pro Ser Gly Thr Glu  Leu Ser Gly 
    1685                 1690                 1695             


Gln Ala  Ser Gly Ser Pro Asp  Val Ser Gly Glu Ile  Pro Gly Leu 
    1700                 1705                 1710             


Phe Gly  Val Ser Gly Gln Pro  Ser Gly Phe Pro Asp  Thr Ser Gly 
    1715                 1720                 1725             


Glu Thr  Ser Gly Val Thr Glu  Leu Ser Gly Leu Ser  Ser Gly Gln 
    1730                 1735                 1740             


Pro Gly  Ile Ser Gly Glu Ala  Ser Gly Val Leu Tyr  Gly Thr Ser 
    1745                 1750                 1755             


Gln Pro  Phe Gly Ile Thr Asp  Leu Ser Gly Glu Thr  Ser Gly Val 
    1760                 1765                 1770             


Pro Asp  Leu Ser Gly Gln Pro  Ser Gly Leu Pro Gly  Phe Ser Gly 
    1775                 1780                 1785             


Ala Thr  Ser Gly Val Pro Asp  Leu Val Ser Gly Thr  Thr Ser Gly 
    1790                 1795                 1800             


Ser Gly  Glu Ser Ser Gly Ile  Thr Phe Val Asp Thr  Ser Leu Val 
    1805                 1810                 1815             


Glu Val  Ala Pro Thr Thr Phe  Lys Glu Glu Glu Gly  Leu Gly Ser 
    1820                 1825                 1830             


Val Glu  Leu Ser Gly Leu Pro  Ser Gly Glu Ala Asp  Leu Ser Gly 
    1835                 1840                 1845             


Lys Ser  Gly Met Val Asp Val  Ser Gly Gln Phe Ser  Gly Thr Val 
    1850                 1855                 1860             


Asp Ser  Ser Gly Phe Thr Ser  Gln Thr Pro Glu Phe  Ser Gly Leu 
    1865                 1870                 1875             


Pro Ser  Gly Ile Ala Glu Val  Ser Gly Glu Ser Ser  Arg Ala Glu 
    1880                 1885                 1890             


Ile Gly  Ser Ser Leu Pro Ser  Gly Ala Tyr Tyr Gly  Ser Gly Thr 
    1895                 1900                 1905             


Pro Ser  Ser Phe Pro Thr Val  Ser Leu Val Asp Arg  Thr Leu Val 
    1910                 1915                 1920             


Glu Ser  Val Thr Gln Ala Pro  Thr Ala Gln Glu Ala  Gly Glu Gly 
    1925                 1930                 1935             


Pro Ser  Gly Ile Leu Glu Leu  Ser Gly Ala His Ser  Gly Ala Pro 
    1940                 1945                 1950             


Asp Met  Ser Gly Glu His Ser  Gly Phe Leu Asp Leu  Ser Gly Leu 
    1955                 1960                 1965             


Gln Ser  Gly Leu Ile Glu Pro  Ser Gly Glu Pro Pro  Gly Thr Pro 
    1970                 1975                 1980             


Tyr Phe  Ser Gly Asp Phe Ala  Ser Thr Thr Asn Val  Ser Gly Glu 
    1985                 1990                 1995             


Ser Ser  Val Ala Met Gly Thr  Ser Gly Glu Ala Ser  Gly Leu Pro 
    2000                 2005                 2010             


Glu Val  Thr Leu Ile Thr Ser  Glu Phe Val Glu Gly  Val Thr Glu 
    2015                 2020                 2025             


Pro Thr  Ile Ser Gln Glu Leu  Gly Gln Arg Pro Pro  Val Thr His 
    2030                 2035                 2040             


Thr Pro  Gln Leu Phe Glu Ser  Ser Gly Lys Val Ser  Thr Ala Gly 
    2045                 2050                 2055             


Asp Ile  Ser Gly Ala Thr Pro  Val Leu Pro Gly Ser  Gly Val Glu 
    2060                 2065                 2070             


Val Ser  Ser Val Pro Glu Ser  Ser Ser Glu Thr Ser  Ala Tyr Pro 
    2075                 2080                 2085             


Glu Ala  Gly Phe Gly Ala Ser  Ala Ala Pro Glu Ala  Ser Arg Glu 
    2090                 2095                 2100             


Asp Ser  Gly Ser Pro Asp Leu  Ser Glu Thr Thr Ser  Ala Phe His 
    2105                 2110                 2115             


Glu Ala  Asn Leu Glu Arg Ser  Ser Gly Leu Gly Val  Ser Gly Ser 
    2120                 2125                 2130             


Thr Leu  Thr Phe Gln Glu Gly  Glu Ala Ser Ala Ala  Pro Glu Val 
    2135                 2140                 2145             


Ser Gly  Glu Ser Thr Thr Thr  Ser Asp Val Gly Thr  Glu Ala Pro 
    2150                 2155                 2160             


Gly Leu  Pro Ser Ala Thr Pro  Thr Ala Ser Gly Asp  Arg Thr Glu 
    2165                 2170                 2175             


Ile Ser  Gly Asp Leu Ser Gly  His Thr Ser Gln Leu  Gly Val Val 
    2180                 2185                 2190             


Ile Ser  Thr Ser Ile Pro Glu  Ser Glu Trp Thr Gln  Gln Thr Gln 
    2195                 2200                 2205             


Arg Pro  Ala Glu Thr His Leu  Glu Ile Glu Ser Ser  Ser Leu Leu 
    2210                 2215                 2220             


Tyr Ser  Gly Glu Glu Thr His  Thr Val Glu Thr Ala  Thr Ser Pro 
    2225                 2230                 2235             


Thr Asp  Ala Ser Ile Pro Ala  Ser Pro Glu Trp Lys  Arg Glu Ser 
    2240                 2245                 2250             


Glu Ser  Thr Ala Ala Asp Gln  Glu Val Cys Glu Glu  Gly Trp Asn 
    2255                 2260                 2265             


Lys Tyr  Gln Gly His Cys Tyr  Arg His Phe Pro Asp  Arg Glu Thr 
    2270                 2275                 2280             


Trp Val  Asp Ala Glu Arg Arg  Cys Arg Glu Gln Gln  Ser His Leu 
    2285                 2290                 2295             


Ser Ser  Ile Val Thr Pro Glu  Glu Gln Glu Phe Val  Asn Asn Asn 
    2300                 2305                 2310             


Ala Gln  Asp Tyr Gln Trp Ile  Gly Leu Asn Asp Arg  Thr Ile Glu 
    2315                 2320                 2325             


Gly Asp  Phe Arg Trp Ser Asp  Gly His Pro Met Gln  Phe Glu Asn 
    2330                 2335                 2340             


Trp Arg  Pro Asn Gln Pro Asp  Asn Phe Phe Ala Ala  Gly Glu Asp 
    2345                 2350                 2355             


Cys Val  Val Met Ile Trp His  Glu Lys Gly Glu Trp  Asn Asp Val 
    2360                 2365                 2370             


Pro Cys  Asn Tyr His Leu Pro  Phe Thr Cys Lys Lys  Gly Thr Val 
    2375                 2380                 2385             


Ala Cys  Gly Glu Pro Pro Val  Val Glu His Ala Arg  Thr Phe Gly 
    2390                 2395                 2400             


Gln Lys  Lys Asp Arg Tyr Glu  Ile Asn Ser Leu Val  Arg Tyr Gln 
    2405                 2410                 2415             


Cys Thr  Glu Gly Phe Val Gln  Arg His Met Pro Thr  Ile Arg Cys 
    2420                 2425                 2430             


Gln Pro  Ser Gly His Trp Glu  Glu Pro Gln Ile Thr  Cys Thr Asp 
    2435                 2440                 2445             


Pro Thr  Thr Tyr Lys Arg Arg  Leu Gln Lys Arg Ser  Ser Arg His 
    2450                 2455                 2460             


Pro Arg  Arg Ser Arg Pro Ser  Thr Ala His 
    2465                 2470             


<210>  108
<211>  156
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  108

Xaa Trp Asn Asp Val Pro Cys Asn Tyr His Leu Pro Phe Thr Cys Lys 
1               5                   10                  15      


Lys Gly Thr Val Ala Cys Gly Glu Pro Pro Val Val Glu His Ala Arg 
            20                  25                  30          


Thr Phe Gly Gln Lys Lys Asp Arg Tyr Glu Ile Asn Ser Leu Val Arg 
        35                  40                  45              


Tyr Gln Cys Thr Glu Gly Phe Val Gln Arg His Met Pro Thr Ile Arg 
    50                  55                  60                  


Cys Gln Pro Ser Gly His Trp Glu Glu Pro Gln Ile Thr Cys Thr Asp 
65                  70                  75                  80  


Arg Glu His His Pro Gly His Leu Ala Glu His Arg Pro Pro Pro Thr 
                85                  90                  95      


Asn Ala Asp Tyr Arg Ser Gly Ala His Gly Thr Leu Gly Gly Ala Ala 
            100                 105                 110         


Pro Ala Gln Pro Thr Glu Lys Ser Phe Gln Asp Ala Pro Arg Thr Leu 
        115                 120                 125             


Ser Pro Gly Ala Cys Gln Ala Asp Val His Pro Thr Gln Thr Val Ser 
    130                 135                 140                 


Ser Ser Cys Arg Phe Leu Ser Tyr Lys Glu Ser His 
145                 150                 155     


<210>  109
<211>  282
<212>  PRT
<213>  Homo Sapiens

<400>  109

Leu Asp Met Glu Thr Thr Tyr Ser Val Ala Thr Val Cys His Pro Asn 
1               5                   10                  15      


Gly Ser Cys Leu Gln Leu Glu Pro Asp Leu Thr Asn Val Met Ala Thr 
            20                  25                  30          


Ser Arg Lys Tyr Glu Asp Leu Leu Trp Ala Trp Glu Gly Trp Arg Asp 
        35                  40                  45              


Lys Ala Gly Arg Ala Ile Leu Gln Phe Tyr Pro Lys Tyr Val Glu Leu 
    50                  55                  60                  


Ile Asn Gln Ala Ala Arg Leu Asn Gly Tyr Val Asp Ala Gly Asp Ser 
65                  70                  75                  80  


Trp Arg Ser Met Tyr Glu Thr Pro Ser Leu Glu Gln Asp Leu Glu Arg 
                85                  90                  95      


Leu Phe Gln Glu Leu Gln Pro Leu Tyr Leu Asn Leu His Ala Tyr Val 
            100                 105                 110         


Arg Arg Ala Leu His Arg His Tyr Gly Ala Gln His Ile Asn Leu Glu 
        115                 120                 125             


Gly Pro Ile Pro Ala His Leu Leu Gly Asn Met Trp Ala Gln Thr Trp 
    130                 135                 140                 


Ser Asn Ile Tyr Asp Leu Val Val Pro Phe Pro Ser Ala Pro Ser Met 
145                 150                 155                 160 


Asp Thr Thr Glu Ala Met Leu Lys Gln Gly Trp Thr Pro Arg Arg Met 
                165                 170                 175     


Phe Lys Glu Ala Asp Asp Phe Phe Thr Ser Leu Gly Leu Leu Pro Val 
            180                 185                 190         


Pro Pro Glu Phe Trp Asn Lys Ser Met Leu Glu Lys Pro Thr Asp Gly 
        195                 200                 205             


Arg Glu Val Val Cys His Ala Ser Ala Trp Asp Phe Tyr Asn Glu His 
    210                 215                 220                 


Asp Ile Asn Phe Leu Met Lys Met Ala Leu Asp Lys Ile Ala Phe Ile 
225                 230                 235                 240 


Pro Phe Ser Tyr Leu Val Asp Gln Trp Arg Trp Arg Val Phe Asp Gly 
                245                 250                 255     


Ser Ile Thr Lys Glu Asn Tyr Asn Gln Glu Trp Trp Ser Leu Arg Leu 
            260                 265                 270         


Lys Tyr Gln Gly Leu Cys Pro Pro Val Pro 
        275                 280         


<210>  110
<211>  314
<212>  PRT
<213>  Homo Sapiens

<400>  110

Met Asp Glu Gly Gly Cys Ser Gln Ala Ala Pro Ala Phe Ala Glu Gly 
1               5                   10                  15      


Ala Gly Leu Gly Ser Gly Ala Pro Ala Leu Ser Gly Ser Cys Leu Leu 
            20                  25                  30          


Thr Ser Gly Arg Cys Arg Cys His Arg His Arg Thr Ala Leu Ser Ile 
        35                  40                  45              


His Pro Pro Leu Ala Arg Pro Leu Phe Trp Ser Gln Phe Leu Leu His 
    50                  55                  60                  


His Ser His Glu Ala Asp Ser Leu Gln Lys Glu Glu Ala Arg Leu Pro 
65                  70                  75                  80  


Gln Thr Lys Glu Glu Ala Ala Leu Leu Ser Gln Glu Phe Ala Glu Ala 
                85                  90                  95      


Trp Gly Gln Lys Ala Lys Glu Leu Tyr Glu Pro Ile Trp Gln Asn Phe 
            100                 105                 110         


Thr Asp Pro Gln Leu Arg Arg Ile Ile Gly Ala Val Arg Thr Leu Gly 
        115                 120                 125             


Ser Ala Asn Leu Pro Leu Ala Lys Arg Gln Gln Tyr Asn Ala Leu Leu 
    130                 135                 140                 


Ser Asn Met Ser Arg Ile Tyr Ser Thr Ala Lys Val Cys Leu Pro Asn 
145                 150                 155                 160 


Lys Thr Ala Thr Cys Trp Ser Leu Asp Pro Asp Leu Thr Asn Ile Leu 
                165                 170                 175     


Ala Ser Ser Arg Ser Tyr Ala Met Leu Leu Phe Ala Trp Glu Gly Trp 
            180                 185                 190         


His Asn Ala Ala Gly Ile Pro Leu Lys Pro Leu Tyr Glu Asp Phe Thr 
        195                 200                 205             


Ala Leu Ser Asn Glu Ala Tyr Lys Gln Asp Gly Phe Thr Asp Thr Gly 
    210                 215                 220                 


Ala Tyr Trp Arg Ser Trp Tyr Asn Ser Pro Thr Phe Glu Asp Asp Leu 
225                 230                 235                 240 


Glu His Leu Tyr Gln Gln Leu Glu Pro Leu Tyr Leu Asn Leu His Ala 
                245                 250                 255     


Phe Val Arg Arg Ala Leu His Arg Arg Tyr Gly Asp Arg Tyr Ile Asn 
            260                 265                 270         


Leu Arg Gly Pro Ile Pro Ala His Leu Leu Gly Asp Met Trp Ala Gln 
        275                 280                 285             


Ser Trp Glu Asn Ile Tyr Asp Met Val Val Pro Phe Pro Asp Lys Pro 
    290                 295                 300                 


Asn Leu Asp Val Thr Ser Thr Met Leu Gln 
305                 310                 


<210>  111
<211>  168
<212>  PRT
<213>  Homo Sapiens

<400>  111

Met Gly Ala Ala Ser Gly Arg Arg Gly Pro Gly Leu Leu Leu Pro Leu 
1               5                   10                  15      


Pro Leu Leu Leu Leu Leu Pro Pro Gln Pro Ala Leu Ala Leu Asp Pro 
            20                  25                  30          


Gly Leu Gln Pro Gly Asn Phe Ser Ala Asp Glu Ala Gly Ala Gln Leu 
        35                  40                  45              


Phe Ala Gln Ser Tyr Asn Ser Ser Ala Glu Gln Val Leu Phe Gln Ser 
    50                  55                  60                  


Val Ala Ala Ser Trp Ala His Asp Thr Asn Ile Thr Ala Glu Asn Ala 
65                  70                  75                  80  


Arg Arg Gln Glu Glu Ala Ala Leu Leu Ser Gln Glu Phe Ala Glu Ala 
                85                  90                  95      


Trp Gly Gln Lys Ala Lys Glu Leu Tyr Glu Pro Ile Trp Gln Asn Phe 
            100                 105                 110         


Thr Asp Pro Gln Leu Arg Arg Ile Ile Gly Ala Val Arg Thr Leu Gly 
        115                 120                 125             


Ser Ala Asn Leu Pro Leu Ala Lys Arg Gln Gln Ile Ser Pro Thr Ser 
    130                 135                 140                 


Trp Leu Pro Arg Glu Ala Thr Pro Cys Ser Cys Leu Pro Gly Arg Ala 
145                 150                 155                 160 


Gly Thr Thr Leu Arg Ala Ser Arg 
                165             


<210>  112
<211>  1306
<212>  PRT
<213>  Homo Sapiens

<400>  112

Met Gly Ala Ala Ser Gly Arg Arg Gly Pro Gly Leu Leu Leu Pro Leu 
1               5                   10                  15      


Pro Leu Leu Leu Leu Leu Pro Pro Gln Pro Ala Leu Ala Leu Asp Pro 
            20                  25                  30          


Gly Leu Gln Pro Gly Asn Phe Ser Ala Asp Glu Ala Gly Ala Gln Leu 
        35                  40                  45              


Phe Ala Gln Ser Tyr Asn Ser Ser Ala Glu Gln Val Leu Phe Gln Ser 
    50                  55                  60                  


Val Ala Ala Ser Trp Ala His Asp Thr Asn Ile Thr Ala Glu Asn Ala 
65                  70                  75                  80  


Arg Arg Gln Glu Glu Ala Ala Leu Leu Ser Gln Glu Phe Ala Glu Ala 
                85                  90                  95      


Trp Gly Gln Lys Ala Lys Glu Leu Tyr Glu Pro Ile Trp Gln Asn Phe 
            100                 105                 110         


Thr Asp Pro Gln Leu Arg Arg Ile Ile Gly Ala Val Arg Thr Leu Gly 
        115                 120                 125             


Ser Ala Asn Leu Pro Leu Ala Lys Arg Gln Gln Tyr Asn Ala Leu Leu 
    130                 135                 140                 


Ser Asn Met Ser Arg Ile Tyr Ser Thr Ala Lys Val Cys Leu Pro Asn 
145                 150                 155                 160 


Lys Thr Ala Thr Cys Trp Ser Leu Asp Pro Asp Leu Thr Asn Ile Leu 
                165                 170                 175     


Ala Ser Ser Arg Ser Tyr Ala Met Leu Leu Phe Ala Trp Glu Gly Trp 
            180                 185                 190         


His Asn Ala Ala Gly Ile Pro Leu Lys Pro Leu Tyr Glu Asp Phe Thr 
        195                 200                 205             


Ala Leu Ser Asn Glu Ala Tyr Lys Gln Asp Gly Phe Thr Asp Thr Gly 
    210                 215                 220                 


Ala Tyr Trp Arg Ser Trp Tyr Asn Ser Pro Thr Phe Glu Asp Asp Leu 
225                 230                 235                 240 


Glu His Leu Tyr Gln Gln Leu Glu Pro Leu Tyr Leu Asn Leu His Ala 
                245                 250                 255     


Phe Val Arg Arg Ala Leu His Arg Arg Tyr Gly Asp Arg Tyr Ile Asn 
            260                 265                 270         


Leu Arg Gly Pro Ile Pro Ala His Leu Leu Gly Asp Met Trp Ala Gln 
        275                 280                 285             


Ser Trp Glu Asn Ile Tyr Asp Met Val Val Pro Phe Pro Asp Lys Pro 
    290                 295                 300                 


Asn Leu Asp Val Thr Ser Thr Met Leu Gln Gln Gly Trp Asn Ala Thr 
305                 310                 315                 320 


His Met Phe Arg Val Ala Glu Glu Phe Phe Thr Ser Leu Glu Leu Ser 
                325                 330                 335     


Pro Met Pro Pro Glu Phe Trp Glu Gly Ser Met Leu Glu Lys Pro Ala 
            340                 345                 350         


Asp Gly Arg Glu Val Val Cys His Ala Ser Ala Trp Asp Phe Tyr Asn 
        355                 360                 365             


Arg Lys Asp Phe Arg Ile Lys Gln Cys Thr Arg Val Thr Met Asp Gln 
    370                 375                 380                 


Leu Ser Thr Val His His Glu Met Gly His Ile Gln Tyr Tyr Leu Gln 
385                 390                 395                 400 


Tyr Lys Asp Leu Pro Val Ser Leu Arg Arg Gly Ala Asn Pro Gly Phe 
                405                 410                 415     


His Glu Ala Ile Gly Asp Val Leu Ala Leu Ser Val Ser Thr Pro Glu 
            420                 425                 430         


His Leu His Lys Ile Gly Leu Leu Asp Arg Val Thr Asn Asp Thr Glu 
        435                 440                 445             


Ser Asp Ile Asn Tyr Leu Leu Lys Met Ala Leu Glu Lys Ile Ala Phe 
    450                 455                 460                 


Leu Pro Phe Gly Tyr Leu Val Asp Gln Trp Arg Trp Gly Val Phe Ser 
465                 470                 475                 480 


Gly Arg Thr Pro Pro Ser Arg Tyr Asn Phe Asp Trp Trp Tyr Leu Arg 
                485                 490                 495     


Thr Lys Tyr Gln Gly Ile Cys Pro Pro Val Thr Arg Asn Glu Thr His 
            500                 505                 510         


Phe Asp Ala Gly Ala Lys Phe His Val Pro Asn Val Thr Pro Tyr Ile 
        515                 520                 525             


Arg Tyr Phe Val Ser Phe Val Leu Gln Phe Gln Phe His Glu Ala Leu 
    530                 535                 540                 


Cys Lys Glu Ala Gly Tyr Glu Gly Pro Leu His Gln Cys Asp Ile Tyr 
545                 550                 555                 560 


Arg Ser Thr Lys Ala Gly Ala Lys Leu Arg Lys Val Leu Gln Ala Gly 
                565                 570                 575     


Ser Ser Arg Pro Trp Gln Glu Val Leu Lys Asp Met Val Gly Leu Asp 
            580                 585                 590         


Ala Leu Asp Ala Gln Pro Leu Leu Lys Tyr Phe Gln Pro Val Thr Gln 
        595                 600                 605             


Trp Leu Gln Glu Gln Asn Gln Gln Asn Gly Glu Val Leu Gly Trp Pro 
    610                 615                 620                 


Glu Tyr Gln Trp His Pro Pro Leu Pro Asp Asn Tyr Pro Glu Gly Ile 
625                 630                 635                 640 


Asp Leu Val Thr Asp Glu Ala Glu Ala Ser Lys Phe Val Glu Glu Tyr 
                645                 650                 655     


Asp Arg Thr Ser Gln Val Val Trp Asn Glu Tyr Ala Glu Ala Asn Trp 
            660                 665                 670         


Asn Tyr Asn Thr Asn Ile Thr Thr Glu Thr Ser Lys Ile Leu Leu Gln 
        675                 680                 685             


Lys Asn Met Gln Ile Ala Asn His Thr Leu Lys Tyr Gly Thr Gln Ala 
    690                 695                 700                 


Arg Lys Phe Asp Val Asn Gln Leu Gln Asn Thr Thr Ile Lys Arg Ile 
705                 710                 715                 720 


Ile Lys Lys Val Gln Asp Leu Glu Arg Ala Ala Leu Pro Ala Gln Glu 
                725                 730                 735     


Leu Glu Glu Tyr Asn Lys Ile Leu Leu Asp Met Glu Thr Thr Tyr Ser 
            740                 745                 750         


Val Ala Thr Val Cys His Pro Asn Gly Ser Cys Leu Gln Leu Glu Pro 
        755                 760                 765             


Asp Leu Thr Asn Val Met Ala Thr Ser Arg Lys Tyr Glu Asp Leu Leu 
    770                 775                 780                 


Trp Ala Trp Glu Gly Trp Arg Asp Lys Ala Gly Arg Ala Ile Leu Gln 
785                 790                 795                 800 


Phe Tyr Pro Lys Tyr Val Glu Leu Ile Asn Gln Ala Ala Arg Leu Asn 
                805                 810                 815     


Gly Tyr Val Asp Ala Gly Asp Ser Trp Arg Ser Met Tyr Glu Thr Pro 
            820                 825                 830         


Ser Leu Glu Gln Asp Leu Glu Arg Leu Phe Gln Glu Leu Gln Pro Leu 
        835                 840                 845             


Tyr Leu Asn Leu His Ala Tyr Val Arg Arg Ala Leu His Arg His Tyr 
    850                 855                 860                 


Gly Ala Gln His Ile Asn Leu Glu Gly Pro Ile Pro Ala His Leu Leu 
865                 870                 875                 880 


Gly Asn Met Trp Ala Gln Thr Trp Ser Asn Ile Tyr Asp Leu Val Val 
                885                 890                 895     


Pro Phe Pro Ser Ala Pro Ser Met Asp Thr Thr Glu Ala Met Leu Lys 
            900                 905                 910         


Gln Gly Trp Thr Pro Arg Arg Met Phe Lys Glu Ala Asp Asp Phe Phe 
        915                 920                 925             


Thr Ser Leu Gly Leu Leu Pro Val Pro Pro Glu Phe Trp Asn Lys Ser 
    930                 935                 940                 


Met Leu Glu Lys Pro Thr Asp Gly Arg Glu Val Val Cys His Ala Ser 
945                 950                 955                 960 


Ala Trp Asp Phe Tyr Asn Gly Lys Asp Phe Arg Ile Lys Gln Cys Thr 
                965                 970                 975     


Thr Val Asn Leu Glu Asp Leu Val Val Ala His His Glu Met Gly His 
            980                 985                 990         


Ile Gln Tyr Phe Met Gln Tyr Lys  Asp Leu Pro Val Ala  Leu Arg Glu 
        995                 1000                 1005             


Gly Ala  Asn Pro Gly Phe His  Glu Ala Ile Gly Asp  Val Leu Ala 
    1010                 1015                 1020             


Leu Ser  Val Ser Thr Pro Lys  His Leu His Ser Leu  Asn Leu Leu 
    1025                 1030                 1035             


Ser Ser  Glu Gly Gly Ser Asp  Glu His Asp Ile Asn  Phe Leu Met 
    1040                 1045                 1050             


Lys Met  Ala Leu Asp Lys Ile  Ala Phe Ile Pro Phe  Ser Tyr Leu 
    1055                 1060                 1065             


Val Asp  Gln Trp Arg Trp Arg  Val Phe Asp Gly Ser  Ile Thr Lys 
    1070                 1075                 1080             


Glu Asn  Tyr Asn Gln Glu Trp  Trp Ser Leu Arg Leu  Lys Tyr Gln 
    1085                 1090                 1095             


Gly Leu  Cys Pro Pro Val Pro  Arg Thr Gln Gly Asp  Phe Asp Pro 
    1100                 1105                 1110             


Gly Ala  Lys Phe His Ile Pro  Ser Ser Val Pro Tyr  Ile Arg Tyr 
    1115                 1120                 1125             


Phe Val  Ser Phe Ile Ile Gln  Phe Gln Phe His Glu  Ala Leu Cys 
    1130                 1135                 1140             


Gln Ala  Ala Gly His Thr Gly  Pro Leu His Lys Cys  Asp Ile Tyr 
    1145                 1150                 1155             


Gln Ser  Lys Glu Ala Gly Gln  Arg Leu Ala Thr Ala  Met Lys Leu 
    1160                 1165                 1170             


Gly Phe  Ser Arg Pro Trp Pro  Glu Ala Met Gln Leu  Ile Thr Gly 
    1175                 1180                 1185             


Gln Pro  Asn Met Ser Ala Ser  Ala Met Leu Ser Tyr  Phe Lys Pro 
    1190                 1195                 1200             


Leu Leu  Asp Trp Leu Arg Thr  Glu Asn Glu Leu His  Gly Glu Lys 
    1205                 1210                 1215             


Leu Gly  Trp Pro Gln Tyr Asn  Trp Thr Pro Asn Ser  Ala Arg Ser 
    1220                 1225                 1230             


Glu Gly  Pro Leu Pro Asp Ser  Gly Arg Val Ser Phe  Leu Gly Leu 
    1235                 1240                 1245             


Asp Leu  Asp Ala Gln Gln Ala  Arg Val Gly Gln Trp  Leu Leu Leu 
    1250                 1255                 1260             


Phe Leu  Gly Ile Ala Leu Leu  Val Ala Thr Leu Gly  Leu Ser Gln 
    1265                 1270                 1275             


Arg Leu  Phe Ser Ile Arg His  Arg Ser Leu His Arg  His Ser His 
    1280                 1285                 1290             


Gly Pro  Gln Phe Gly Ser Glu  Val Glu Leu Arg His  Ser 
    1295                 1300                 1305     


<210>  113
<211>  1242
<212>  PRT
<213>  Homo Sapiens

<400>  113

Met Gly Ala Ala Ser Gly Arg Arg Gly Pro Gly Leu Leu Leu Pro Leu 
1               5                   10                  15      


Pro Leu Leu Leu Leu Leu Pro Pro Gln Pro Ala Leu Ala Leu Asp Pro 
            20                  25                  30          


Gly Leu Gln Pro Gly Asn Phe Ser Ala Asp Glu Ala Gly Ala Gln Leu 
        35                  40                  45              


Phe Ala Gln Ser Tyr Asn Ser Ser Ala Glu Gln Val Leu Phe Gln Ser 
    50                  55                  60                  


Val Ala Ala Ser Trp Ala His Asp Thr Asn Ile Thr Ala Glu Asn Ala 
65                  70                  75                  80  


Arg Arg Gln Glu Glu Ala Ala Leu Leu Ser Gln Glu Phe Ala Glu Ala 
                85                  90                  95      


Trp Gly Gln Lys Ala Lys Glu Leu Tyr Glu Pro Ile Trp Gln Asn Phe 
            100                 105                 110         


Thr Asp Pro Gln Leu Arg Arg Ile Ile Gly Ala Val Arg Thr Leu Gly 
        115                 120                 125             


Ser Ala Asn Leu Pro Leu Ala Lys Arg Gln Gln Tyr Asn Ala Leu Leu 
    130                 135                 140                 


Ser Asn Met Ser Arg Ile Tyr Ser Thr Ala Lys Val Cys Leu Pro Asn 
145                 150                 155                 160 


Lys Thr Ala Thr Cys Trp Ser Leu Asp Pro Asp Leu Thr Asn Ile Leu 
                165                 170                 175     


Ala Ser Ser Arg Ser Tyr Ala Met Leu Leu Phe Ala Trp Glu Gly Trp 
            180                 185                 190         


His Asn Ala Ala Gly Ile Pro Leu Lys Pro Leu Tyr Glu Asp Phe Thr 
        195                 200                 205             


Ala Leu Ser Asn Glu Ala Tyr Lys Gln Asp Gly Phe Thr Asp Thr Gly 
    210                 215                 220                 


Ala Tyr Trp Arg Ser Trp Tyr Asn Ser Pro Thr Phe Glu Asp Asp Leu 
225                 230                 235                 240 


Glu His Leu Tyr Gln Gln Leu Glu Pro Leu Tyr Leu Asn Leu His Ala 
                245                 250                 255     


Phe Val Arg Arg Ala Leu His Arg Arg Tyr Gly Asp Arg Tyr Ile Asn 
            260                 265                 270         


Leu Arg Gly Pro Ile Pro Ala His Leu Leu Gly Asp Met Trp Ala Gln 
        275                 280                 285             


Ser Trp Glu Asn Ile Tyr Asp Met Val Val Pro Phe Pro Asp Lys Pro 
    290                 295                 300                 


Asn Leu Asp Val Thr Ser Thr Met Leu Gln Gln Gly Trp Asn Ala Thr 
305                 310                 315                 320 


His Met Phe Arg Val Ala Glu Glu Phe Phe Thr Ser Leu Glu Leu Ser 
                325                 330                 335     


Pro Met Pro Pro Glu Phe Trp Glu Gly Ser Met Leu Glu Lys Pro Ala 
            340                 345                 350         


Asp Gly Arg Glu Val Val Cys His Ala Ser Ala Trp Asp Phe Tyr Asn 
        355                 360                 365             


Arg Lys Asp Phe Arg Ile Lys Gln Cys Thr Arg Val Thr Met Asp Gln 
    370                 375                 380                 


Leu Ser Thr Val His His Glu Met Gly His Ile Gln Tyr Tyr Leu Gln 
385                 390                 395                 400 


Tyr Lys Asp Leu Pro Val Ser Leu Arg Arg Gly Ala Asn Pro Gly Phe 
                405                 410                 415     


His Glu Ala Ile Gly Asp Val Leu Ala Leu Ser Val Ser Thr Pro Glu 
            420                 425                 430         


His Leu His Lys Ile Gly Leu Leu Asp Arg Val Thr Asn Asp Thr Glu 
        435                 440                 445             


Ser Asp Ile Asn Tyr Leu Leu Lys Met Ala Leu Glu Lys Ile Ala Phe 
    450                 455                 460                 


Leu Pro Phe Gly Tyr Leu Val Asp Gln Trp Arg Trp Gly Val Phe Ser 
465                 470                 475                 480 


Gly Arg Thr Pro Pro Ser Arg Tyr Asn Phe Asp Trp Trp Tyr Leu Arg 
                485                 490                 495     


Thr Lys Tyr Gln Gly Ile Cys Pro Pro Val Thr Arg Asn Glu Thr His 
            500                 505                 510         


Phe Asp Ala Gly Ala Lys Phe His Val Pro Asn Val Thr Pro Tyr Ile 
        515                 520                 525             


Arg Tyr Phe Val Ser Phe Val Leu Gln Phe Gln Phe His Glu Ala Leu 
    530                 535                 540                 


Cys Lys Glu Ala Gly Tyr Glu Gly Pro Leu His Gln Cys Asp Ile Tyr 
545                 550                 555                 560 


Arg Ser Thr Lys Ala Gly Ala Lys Leu Arg Lys Val Leu Gln Ala Gly 
                565                 570                 575     


Ser Ser Arg Pro Trp Gln Glu Val Leu Lys Asp Met Val Gly Leu Asp 
            580                 585                 590         


Ala Leu Asp Ala Gln Pro Leu Leu Lys Tyr Phe Gln Pro Val Thr Gln 
        595                 600                 605             


Trp Leu Gln Glu Gln Asn Gln Gln Asn Gly Glu Val Leu Gly Trp Pro 
    610                 615                 620                 


Glu Tyr Gln Trp His Pro Pro Leu Pro Asp Asn Tyr Pro Glu Gly Ile 
625                 630                 635                 640 


Asp Leu Val Thr Asp Glu Ala Glu Ala Ser Lys Phe Val Glu Glu Tyr 
                645                 650                 655     


Asp Arg Thr Ser Gln Val Val Trp Asn Glu Tyr Ala Glu Ala Asn Trp 
            660                 665                 670         


Asn Tyr Asn Thr Asn Ile Thr Thr Glu Thr Ser Lys Ile Leu Leu Gln 
        675                 680                 685             


Lys Asn Met Gln Ile Ala Asn His Thr Leu Lys Tyr Gly Thr Gln Ala 
    690                 695                 700                 


Arg Lys Phe Asp Val Asn Gln Leu Gln Asn Thr Thr Ile Lys Arg Ile 
705                 710                 715                 720 


Ile Lys Lys Val Gln Asp Leu Glu Arg Ala Ala Leu Pro Ala Gln Glu 
                725                 730                 735     


Leu Glu Glu Tyr Asn Lys Ile Leu Leu Asp Met Glu Thr Thr Tyr Ser 
            740                 745                 750         


Val Ala Thr Val Cys His Pro Asn Gly Ser Cys Leu Gln Leu Glu Pro 
        755                 760                 765             


Asp Leu Thr Asn Val Met Ala Thr Ser Arg Lys Tyr Glu Asp Leu Leu 
    770                 775                 780                 


Trp Ala Trp Glu Gly Trp Arg Asp Lys Ala Gly Arg Ala Ile Leu Gln 
785                 790                 795                 800 


Phe Tyr Pro Lys Tyr Val Glu Leu Ile Asn Gln Ala Ala Arg Leu Asn 
                805                 810                 815     


Gly Tyr Val Asp Ala Gly Asp Ser Trp Arg Ser Met Tyr Glu Thr Pro 
            820                 825                 830         


Ser Leu Glu Gln Asp Leu Glu Arg Leu Phe Gln Glu Leu Gln Pro Leu 
        835                 840                 845             


Tyr Leu Asn Leu His Ala Tyr Val Arg Arg Ala Leu His Arg His Tyr 
    850                 855                 860                 


Gly Ala Gln His Ile Asn Leu Glu Gly Pro Ile Pro Ala His Leu Leu 
865                 870                 875                 880 


Gly Asn Met Trp Ala Gln Thr Trp Ser Asn Ile Tyr Asp Leu Val Val 
                885                 890                 895     


Pro Phe Pro Ser Ala Pro Ser Met Asp Thr Thr Glu Ala Met Leu Lys 
            900                 905                 910         


Gln Gly Trp Thr Pro Arg Arg Met Phe Lys Glu Ala Asp Asp Phe Phe 
        915                 920                 925             


Thr Ser Leu Gly Leu Leu Pro Val Pro Pro Glu Phe Trp Asn Lys Ser 
    930                 935                 940                 


Met Leu Glu Lys Pro Thr Asp Gly Arg Glu Val Val Cys His Ala Ser 
945                 950                 955                 960 


Ala Trp Asp Phe Tyr Asn Gly Lys Asp Phe Arg Ile Lys Gln Cys Thr 
                965                 970                 975     


Thr Val Asn Leu Glu Asp Leu Val Val Ala His His Glu Met Gly His 
            980                 985                 990         


Ile Gln Tyr Phe Met Gln Tyr Lys  Asp Leu Pro Val Ala  Leu Arg Glu 
        995                 1000                 1005             


Gly Ala  Asn Pro Gly Phe His  Glu Ala Ile Gly Asp  Val Leu Ala 
    1010                 1015                 1020             


Leu Ser  Val Ser Thr Pro Lys  His Leu His Ser Leu  Asn Leu Leu 
    1025                 1030                 1035             


Ser Ser  Glu Gly Gly Ser Asp  Glu His Asp Ile Asn  Phe Leu Met 
    1040                 1045                 1050             


Lys Met  Ala Leu Asp Lys Ile  Ala Phe Ile Pro Phe  Ser Tyr Leu 
    1055                 1060                 1065             


Val Asp  Gln Trp Arg Trp Arg  Val Phe Asp Gly Ser  Ile Thr Lys 
    1070                 1075                 1080             


Glu Asn  Tyr Asn Gln Glu Trp  Trp Ser Leu Arg Leu  Lys Tyr Gln 
    1085                 1090                 1095             


Gly Leu  Cys Pro Pro Val Pro  Arg Thr Gln Gly Asp  Phe Asp Pro 
    1100                 1105                 1110             


Gly Ala  Lys Phe His Ile Pro  Ser Ser Val Pro Tyr  Ile Arg Tyr 
    1115                 1120                 1125             


Phe Val  Ser Phe Ile Ile Gln  Phe Gln Phe His Glu  Ala Leu Cys 
    1130                 1135                 1140             


Gln Ala  Ala Gly His Thr Gly  Pro Leu His Lys Cys  Asp Ile Tyr 
    1145                 1150                 1155             


Gln Ser  Lys Glu Ala Gly Gln  Arg Leu Ala Thr Ala  Met Lys Leu 
    1160                 1165                 1170             


Gly Phe  Ser Arg Pro Trp Pro  Glu Ala Met Gln Leu  Ile Thr Gly 
    1175                 1180                 1185             


Gln Pro  Asn Met Ser Ala Ser  Ala Met Leu Ser Tyr  Phe Lys Pro 
    1190                 1195                 1200             


Leu Leu  Asp Trp Leu Arg Thr  Glu Asn Glu Leu His  Gly Glu Lys 
    1205                 1210                 1215             


Leu Gly  Trp Pro Gln Tyr Asn  Trp Thr Pro Asn Ser  Gly Thr Ala 
    1220                 1225                 1230             


Thr His  Pro Thr Ser Ser Leu  Gly Ser 
    1235                 1240         


<210>  114
<211>  36
<212>  PRT
<213>  Homo Sapiens

<400>  114

Met Gly Gln Gly Trp Ala Thr Ala Gly Leu Pro Ser Leu Leu Phe Leu 
1               5                   10                  15      


Leu Leu Cys Tyr Gly His Pro Leu Leu Val Pro Ser Gln Glu Ala Ser 
            20                  25                  30          


Gln Gln Thr Trp 
        35      


<210>  115
<211>  36
<212>  PRT
<213>  Homo Sapiens

<400>  115

Met Gly Gln Gly Trp Ala Thr Ala Gly Leu Pro Ser Leu Leu Phe Leu 
1               5                   10                  15      


Leu Leu Cys Tyr Gly His Pro Leu Leu Val Pro Ser Gln Glu Ala Ser 
            20                  25                  30          


Gln Gln Thr Trp 
        35      


<210>  116
<211>  145
<212>  PRT
<213>  Homo Sapiens

<400>  116

Met Gly Gln Gly Trp Ala Thr Ala Gly Leu Pro Ser Leu Leu Phe Leu 
1               5                   10                  15      


Leu Leu Cys Tyr Gly His Pro Leu Leu Val Pro Ser Gln Glu Ala Ser 
            20                  25                  30          


Gln Gln Val Thr Val Thr His Gly Thr Ser Ser Gln Ala Thr Thr Ser 
        35                  40                  45              


Ser Gln Thr Thr Thr His Gln Ala Thr Ala His Gln Thr Ser Ala Gln 
    50                  55                  60                  


Ser Pro Asn Leu Val Thr Asp Glu Ala Glu Ala Ser Lys Phe Val Glu 
65                  70                  75                  80  


Glu Tyr Asp Arg Thr Ser Gln Val Val Trp Asn Glu Tyr Ala Glu Ala 
                85                  90                  95      


Asn Trp Asn Tyr Asn Thr Asn Ile Thr Thr Glu Thr Ser Lys Ile Leu 
            100                 105                 110         


Gly Leu Tyr Asp Thr Trp Gly Ser Ser Leu Leu Cys Pro Cys Leu Asp 
        115                 120                 125             


Met Cys Cys Leu Thr Ala Gly Ile Gln Gly Gly Cys Arg Arg Thr Cys 
    130                 135                 140                 


Lys 
145 


<210>  117
<211>  208
<212>  PRT
<213>  Homo Sapiens

<400>  117

Met Gly Gln Gly Trp Ala Thr Ala Gly Leu Pro Ser Leu Leu Phe Leu 
1               5                   10                  15      


Leu Leu Cys Tyr Gly His Pro Leu Leu Val Pro Ser Gln Glu Ala Ser 
            20                  25                  30          


Gln Gln Val Thr Val Thr His Gly Thr Ser Ser Gln Ala Thr Thr Ser 
        35                  40                  45              


Ser Gln Thr Thr Thr His Gln Ala Thr Ala His Gln Thr Ser Ala Gln 
    50                  55                  60                  


Ser Pro Asn Leu Val Thr Asp Glu Ala Glu Ala Ser Lys Phe Val Glu 
65                  70                  75                  80  


Glu Tyr Asp Arg Thr Ser Gln Val Val Trp Asn Glu Tyr Ala Glu Ala 
                85                  90                  95      


Asn Trp Asn Tyr Asn Thr Asn Ile Thr Thr Glu Thr Ser Lys Ile Leu 
            100                 105                 110         


Leu Gln Lys Asn Met Gln Ile Ala Asn His Thr Leu Lys Tyr Gly Thr 
        115                 120                 125             


Gln Ala Arg Lys Phe Asp Val Asn Gln Leu Gln Asn Thr Thr Ile Lys 
    130                 135                 140                 


Arg Ile Ile Lys Lys Val Gln Asp Leu Glu Arg Ala Ala Leu Pro Ala 
145                 150                 155                 160 


Gln Glu Leu Glu Glu Tyr Asn Lys Ile Leu Leu Asp Met Glu Thr Thr 
                165                 170                 175     


Tyr Ser Val Ala Thr Val Cys His Pro Asn Gly Ser Cys Leu Gln Leu 
            180                 185                 190         


Glu Pro Ala Leu Lys Phe Ser Glu Leu Pro Leu Gln Ala Glu Val Ser 
        195                 200                 205             


<210>  118
<211>  732
<212>  PRT
<213>  Homo Sapiens

<400>  118

Met Gly Gln Gly Trp Ala Thr Ala Gly Leu Pro Ser Leu Leu Phe Leu 
1               5                   10                  15      


Leu Leu Cys Tyr Gly His Pro Leu Leu Val Pro Ser Gln Glu Ala Ser 
            20                  25                  30          


Gln Gln Val Thr Val Thr His Gly Thr Ser Ser Gln Ala Thr Thr Ser 
        35                  40                  45              


Ser Gln Thr Thr Thr His Gln Ala Thr Ala His Gln Thr Ser Ala Gln 
    50                  55                  60                  


Ser Pro Asn Leu Val Thr Asp Glu Ala Glu Ala Ser Lys Phe Val Glu 
65                  70                  75                  80  


Glu Tyr Asp Arg Thr Ser Gln Val Val Trp Asn Glu Tyr Ala Glu Ala 
                85                  90                  95      


Asn Trp Asn Tyr Asn Thr Asn Ile Thr Thr Glu Thr Ser Lys Ile Leu 
            100                 105                 110         


Leu Gln Lys Asn Met Gln Ile Ala Asn His Thr Leu Lys Tyr Gly Thr 
        115                 120                 125             


Gln Ala Arg Lys Phe Asp Val Asn Gln Leu Gln Asn Thr Thr Ile Lys 
    130                 135                 140                 


Arg Ile Ile Lys Lys Val Gln Asp Leu Glu Arg Ala Ala Leu Pro Ala 
145                 150                 155                 160 


Gln Glu Leu Glu Glu Tyr Asn Lys Ile Leu Leu Asp Met Glu Thr Thr 
                165                 170                 175     


Tyr Ser Val Ala Thr Val Cys His Pro Asn Gly Ser Cys Leu Gln Leu 
            180                 185                 190         


Glu Pro Asp Leu Thr Asn Val Met Ala Thr Ser Arg Lys Tyr Glu Asp 
        195                 200                 205             


Leu Leu Trp Ala Trp Glu Gly Trp Arg Asp Lys Ala Gly Arg Ala Ile 
    210                 215                 220                 


Leu Gln Phe Tyr Pro Lys Tyr Val Glu Leu Ile Asn Gln Ala Ala Arg 
225                 230                 235                 240 


Leu Asn Gly Tyr Val Asp Ala Gly Asp Ser Trp Arg Ser Met Tyr Glu 
                245                 250                 255     


Thr Pro Ser Leu Glu Gln Asp Leu Glu Arg Leu Phe Gln Glu Leu Gln 
            260                 265                 270         


Pro Leu Tyr Leu Asn Leu His Ala Tyr Val Arg Arg Ala Leu His Arg 
        275                 280                 285             


His Tyr Gly Ala Gln His Ile Asn Leu Glu Gly Pro Ile Pro Ala His 
    290                 295                 300                 


Leu Leu Gly Asn Met Trp Ala Gln Thr Trp Ser Asn Ile Tyr Asp Leu 
305                 310                 315                 320 


Val Val Pro Phe Pro Ser Ala Pro Ser Met Asp Thr Thr Glu Ala Met 
                325                 330                 335     


Leu Lys Gln Gly Trp Thr Pro Arg Arg Met Phe Lys Glu Ala Asp Asp 
            340                 345                 350         


Phe Phe Thr Ser Leu Gly Leu Leu Pro Val Pro Pro Glu Phe Trp Asn 
        355                 360                 365             


Lys Ser Met Leu Glu Lys Pro Thr Asp Gly Arg Glu Val Val Cys His 
    370                 375                 380                 


Ala Ser Ala Trp Asp Phe Tyr Asn Gly Lys Asp Phe Arg Ile Lys Gln 
385                 390                 395                 400 


Cys Thr Thr Val Asn Leu Glu Asp Leu Val Val Ala His His Glu Met 
                405                 410                 415     


Gly His Ile Gln Tyr Phe Met Gln Tyr Lys Asp Leu Pro Val Ala Leu 
            420                 425                 430         


Arg Glu Gly Ala Asn Pro Gly Phe His Glu Ala Ile Gly Asp Val Leu 
        435                 440                 445             


Ala Leu Ser Val Ser Thr Pro Lys His Leu His Ser Leu Asn Leu Leu 
    450                 455                 460                 


Ser Ser Glu Gly Gly Ser Asp Glu His Asp Ile Asn Phe Leu Met Lys 
465                 470                 475                 480 


Met Ala Leu Asp Lys Ile Ala Phe Ile Pro Phe Ser Tyr Leu Val Asp 
                485                 490                 495     


Gln Trp Arg Trp Arg Val Phe Asp Gly Ser Ile Thr Lys Glu Asn Tyr 
            500                 505                 510         


Asn Gln Glu Trp Trp Ser Leu Arg Leu Lys Tyr Gln Gly Leu Cys Pro 
        515                 520                 525             


Pro Val Pro Arg Thr Gln Gly Asp Phe Asp Pro Gly Ala Lys Phe His 
    530                 535                 540                 


Ile Pro Ser Ser Val Pro Tyr Ile Arg Tyr Phe Val Ser Phe Ile Ile 
545                 550                 555                 560 


Gln Phe Gln Phe His Glu Ala Leu Cys Gln Ala Ala Gly His Thr Gly 
                565                 570                 575     


Pro Leu His Lys Cys Asp Ile Tyr Gln Ser Lys Glu Ala Gly Gln Arg 
            580                 585                 590         


Leu Ala Thr Ala Met Lys Leu Gly Phe Ser Arg Pro Trp Pro Glu Ala 
        595                 600                 605             


Met Gln Leu Ile Thr Gly Gln Pro Asn Met Ser Ala Ser Ala Met Leu 
    610                 615                 620                 


Ser Tyr Phe Lys Pro Leu Leu Asp Trp Leu Arg Thr Glu Asn Glu Leu 
625                 630                 635                 640 


His Gly Glu Lys Leu Gly Trp Pro Gln Tyr Asn Trp Thr Pro Asn Ser 
                645                 650                 655     


Ala Arg Ser Glu Gly Pro Leu Pro Asp Ser Gly Arg Val Ser Phe Leu 
            660                 665                 670         


Gly Leu Asp Leu Asp Ala Gln Gln Ala Arg Val Gly Gln Trp Leu Leu 
        675                 680                 685             


Leu Phe Leu Gly Ile Ala Leu Leu Val Ala Thr Leu Gly Leu Ser Gln 
    690                 695                 700                 


Arg Leu Phe Ser Ile Arg His Arg Ser Leu His Arg His Ser His Gly 
705                 710                 715                 720 


Pro Gln Phe Gly Ser Glu Val Glu Leu Arg His Ser 
                725                 730         


<210>  119
<211>  691
<212>  PRT
<213>  Homo Sapiens

<400>  119

Met Gly Gln Gly Trp Ala Thr Ala Gly Leu Pro Ser Leu Leu Phe Leu 
1               5                   10                  15      


Leu Leu Cys Tyr Gly His Pro Leu Leu Val Pro Ser Gln Glu Ala Ser 
            20                  25                  30          


Gln Gln Val Thr Val Thr His Gly Thr Ser Ser Gln Ala Thr Thr Ser 
        35                  40                  45              


Ser Gln Thr Thr Thr His Gln Ala Thr Ala His Gln Thr Ser Ala Gln 
    50                  55                  60                  


Ser Pro Asn Leu Val Thr Asp Glu Ala Glu Ala Ser Lys Phe Val Glu 
65                  70                  75                  80  


Glu Tyr Asp Arg Thr Ser Gln Val Val Trp Asn Glu Tyr Ala Glu Ala 
                85                  90                  95      


Asn Trp Asn Tyr Asn Thr Asn Ile Thr Thr Glu Thr Ser Lys Ile Leu 
            100                 105                 110         


Leu Gln Lys Asn Met Gln Ile Ala Asn His Thr Leu Lys Tyr Gly Thr 
        115                 120                 125             


Gln Ala Arg Lys Phe Asp Val Asn Gln Leu Gln Asn Thr Thr Ile Lys 
    130                 135                 140                 


Arg Ile Ile Lys Lys Val Gln Asp Leu Glu Arg Ala Ala Leu Pro Ala 
145                 150                 155                 160 


Gln Glu Leu Glu Glu Tyr Asn Lys Ile Leu Leu Asp Met Glu Thr Thr 
                165                 170                 175     


Tyr Ser Val Ala Thr Val Cys His Pro Asn Gly Ser Cys Leu Gln Leu 
            180                 185                 190         


Glu Pro Asp Leu Thr Asn Val Met Ala Thr Ser Arg Lys Tyr Glu Asp 
        195                 200                 205             


Leu Leu Trp Ala Trp Glu Gly Trp Arg Asp Lys Ala Gly Arg Ala Ile 
    210                 215                 220                 


Leu Gln Phe Tyr Pro Lys Tyr Val Glu Leu Ile Asn Gln Ala Ala Arg 
225                 230                 235                 240 


Leu Asn Gly Tyr Val Asp Ala Gly Asp Ser Trp Arg Ser Met Tyr Glu 
                245                 250                 255     


Thr Pro Ser Leu Glu Gln Asp Leu Glu Arg Leu Phe Gln Glu Leu Gln 
            260                 265                 270         


Pro Leu Tyr Leu Asn Leu His Ala Tyr Val Arg Arg Ala Leu His Arg 
        275                 280                 285             


His Tyr Gly Ala Gln His Ile Asn Leu Glu Gly Pro Ile Pro Ala His 
    290                 295                 300                 


Leu Leu Gly Asn Met Trp Ala Gln Thr Trp Ser Asn Ile Tyr Asp Leu 
305                 310                 315                 320 


Val Val Pro Phe Pro Ser Ala Pro Ser Met Asp Thr Thr Glu Ala Met 
                325                 330                 335     


Leu Lys Gln Gly Trp Thr Pro Arg Arg Met Phe Lys Glu Ala Asp Asp 
            340                 345                 350         


Phe Phe Thr Ser Leu Gly Leu Leu Pro Val Pro Pro Glu Phe Trp Asn 
        355                 360                 365             


Lys Ser Met Leu Glu Lys Pro Thr Asp Gly Arg Glu Val Val Cys His 
    370                 375                 380                 


Ala Ser Ala Trp Asp Phe Tyr Asn Gly Lys Asp Phe Arg Ile Lys Gln 
385                 390                 395                 400 


Cys Thr Thr Val Asn Leu Glu Asp Leu Val Val Ala His His Glu Met 
                405                 410                 415     


Gly His Ile Gln Tyr Phe Met Gln Tyr Lys Asp Leu Pro Val Ala Leu 
            420                 425                 430         


Arg Glu Gly Ala Asn Pro Gly Phe His Glu Ala Ile Gly Asp Val Leu 
        435                 440                 445             


Ala Leu Ser Val Ser Thr Pro Lys His Leu His Ser Leu Asn Leu Leu 
    450                 455                 460                 


Ser Ser Glu Gly Gly Ser Asp Glu His Asp Ile Asn Phe Leu Met Lys 
465                 470                 475                 480 


Met Ala Leu Asp Lys Ile Ala Phe Ile Pro Phe Ser Tyr Leu Val Asp 
                485                 490                 495     


Gln Trp Arg Trp Arg Val Phe Asp Gly Ser Ile Thr Lys Glu Asn Tyr 
            500                 505                 510         


Asn Gln Glu Trp Trp Ser Leu Arg Leu Lys Tyr Gln Gly Leu Cys Pro 
        515                 520                 525             


Pro Val Pro Arg Thr Gln Gly Asp Phe Asp Pro Gly Ala Lys Phe His 
    530                 535                 540                 


Ile Pro Ser Ser Val Pro Tyr Ile Arg Thr Ala Met Lys Leu Gly Phe 
545                 550                 555                 560 


Ser Arg Pro Trp Pro Glu Ala Met Gln Leu Ile Thr Gly Gln Pro Asn 
                565                 570                 575     


Met Ser Ala Ser Ala Met Leu Ser Tyr Phe Lys Pro Leu Leu Asp Trp 
            580                 585                 590         


Leu Arg Thr Glu Asn Glu Leu His Gly Glu Lys Leu Gly Trp Pro Gln 
        595                 600                 605             


Tyr Asn Trp Thr Pro Asn Ser Ala Arg Ser Glu Gly Pro Leu Pro Asp 
    610                 615                 620                 


Ser Gly Arg Val Ser Phe Leu Gly Leu Asp Leu Asp Ala Gln Gln Ala 
625                 630                 635                 640 


Arg Val Gly Gln Trp Leu Leu Leu Phe Leu Gly Ile Ala Leu Leu Val 
                645                 650                 655     


Ala Thr Leu Gly Leu Ser Gln Arg Leu Phe Ser Ile Arg His Arg Ser 
            660                 665                 670         


Leu His Arg His Ser His Gly Pro Gln Phe Gly Ser Glu Val Glu Leu 
        675                 680                 685             


Arg His Ser 
    690     


<210>  120
<211>  119
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  120

Xaa Gln Ala Gly Ser Ser Arg Pro Trp Gln Glu Val Leu Lys Asp Met 
1               5                   10                  15      


Val Gly Leu Asp Ala Leu Asp Ala Gln Pro Leu Leu Lys Tyr Phe Gln 
            20                  25                  30          


Pro Val Thr Gln Trp Leu Gln Glu Gln Asn Gln Gln Asn Gly Glu Val 
        35                  40                  45              


Leu Gly Trp Pro Glu Tyr Gln Trp His Pro Pro Leu Pro Asp Asn Tyr 
    50                  55                  60                  


Pro Glu Gly Ile Gly Asp Ser His Pro Trp Asp Lys Gln Pro Gly Asn 
65                  70                  75                  80  


Asn Gln Gln Pro Asp Asn His Pro Pro Gly Asp Gly Pro Pro Asp Ile 
                85                  90                  95      


Ser Pro Glu Pro Lys Trp Asp His Ala Gly Glu Gly Gln Gly Ala Arg 
            100                 105                 110         


Gly Gly Arg Gly Gly Ala Gly 
        115                 


<210>  121
<211>  138
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  121

Xaa Arg Thr Gln Gly Asp Phe Asp Pro Gly Ala Lys Phe His Ile Pro 
1               5                   10                  15      


Ser Ser Val Pro Tyr Ile Arg Tyr Phe Val Ser Phe Ile Ile Gln Phe 
            20                  25                  30          


Gln Phe His Glu Ala Leu Cys Gln Ala Ala Gly His Thr Gly Pro Leu 
        35                  40                  45              


His Lys Cys Asp Ile Tyr Gln Ser Lys Glu Ala Gly Gln Arg Leu Ala 
    50                  55                  60                  


Thr Ala Met Lys Leu Gly Phe Ser Arg Pro Trp Pro Glu Ala Met Gln 
65                  70                  75                  80  


Leu Ile Thr Gly Gln Pro Asn Met Ser Ala Ser Ala Met Leu Ser Tyr 
                85                  90                  95      


Phe Lys Pro Leu Leu Asp Trp Leu Arg Thr Glu Asn Glu Leu His Gly 
            100                 105                 110         


Glu Lys Leu Gly Trp Pro Gln Tyr Asn Trp Thr Pro Asn Ser Gly Thr 
        115                 120                 125             


Ala Thr His Pro Thr Ser Ser Leu Gly Ser 
    130                 135             


<210>  122
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  122

Met Leu Gly Leu Val Met Ser Cys Pro Asp Arg Thr Leu Val Thr Lys 
1               5                   10                  15      


Val Arg Ser His Pro Ser Gly Asn Gln His Arg Pro Thr Arg Gly Gly 
            20                  25                  30          


Ser Arg Ser Phe His Cys Arg Arg Gly Val Arg Pro Arg Pro Ala Ala 
        35                  40                  45              


Leu Arg Val Leu Pro Arg Cys Pro Ala Phe Ser Asp Ala Ala Cys Pro 
    50                  55                  60                  


Ala Ala Met Arg Pro Pro Gln Cys Leu Leu His Thr Pro Ser Leu Ala 
65                  70                  75                  80  


Ser Pro Leu Leu Leu Leu Leu Leu Trp Leu Leu Gly Gly Gly 
                85                  90                  


<210>  123
<211>  55
<212>  PRT
<213>  Homo Sapiens

<400>  123

Met Arg Pro Pro Gln Cys Leu Leu His Thr Pro Ser Leu Ala Ser Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Trp Leu Leu Gly Gly Gly Val Gly Ala Glu 
            20                  25                  30          


Gly Arg Glu Asp Ala Glu Leu Leu Val Thr Val Leu Arg Ala Pro Arg 
        35                  40                  45              


Cys Gly Thr Pro Thr Val Ser 
    50                  55  


<210>  124
<211>  159
<212>  PRT
<213>  Homo Sapiens

<400>  124

Met Arg Pro Pro Gln Cys Leu Leu His Thr Pro Ser Leu Ala Ser Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Trp Leu Leu Gly Gly Gly Val Gly Ala Glu 
            20                  25                  30          


Gly Arg Glu Asp Ala Glu Leu Leu Val Thr Val Arg Gly Gly Arg Leu 
        35                  40                  45              


Arg Gly Ile Arg Leu Lys Thr Pro Gly Gly Pro Val Ser Ala Phe Leu 
    50                  55                  60                  


Gly Ile Pro Phe Ala Glu Pro Pro Met Gly Pro Arg Arg Phe Leu Pro 
65                  70                  75                  80  


Pro Glu Pro Lys Gln Pro Trp Ser Gly Val Val Asp Ala Thr Thr Phe 
                85                  90                  95      


Gln Ser Val Cys Tyr Gln Tyr Val Asp Thr Leu Tyr Pro Gly Phe Glu 
            100                 105                 110         


Gly Thr Glu Met Trp Asn Pro Asn Arg Glu Leu Ser Glu Asp Cys Leu 
        115                 120                 125             


Tyr Leu Asn Val Trp Thr Pro Tyr Pro Arg Pro Thr Ser Pro Thr Pro 
    130                 135                 140                 


Val Leu Val Trp Ile Tyr Gly Gly Gly Phe Tyr Ser Gly Ala Ser 
145                 150                 155                 


<210>  125
<211>  614
<212>  PRT
<213>  Homo Sapiens

<400>  125

Met Arg Pro Pro Gln Cys Leu Leu His Thr Pro Ser Leu Ala Ser Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Trp Leu Leu Gly Gly Gly Val Gly Ala Glu 
            20                  25                  30          


Gly Arg Glu Asp Ala Glu Leu Leu Val Thr Val Arg Gly Gly Arg Leu 
        35                  40                  45              


Arg Gly Ile Arg Leu Lys Thr Pro Gly Gly Pro Val Ser Ala Phe Leu 
    50                  55                  60                  


Gly Ile Pro Phe Ala Glu Pro Pro Met Gly Pro Arg Arg Phe Leu Pro 
65                  70                  75                  80  


Pro Glu Pro Lys Gln Pro Trp Ser Gly Val Val Asp Ala Thr Thr Phe 
                85                  90                  95      


Gln Ser Val Cys Tyr Gln Tyr Val Asp Thr Leu Tyr Pro Gly Phe Glu 
            100                 105                 110         


Gly Thr Glu Met Trp Asn Pro Asn Arg Glu Leu Ser Glu Asp Cys Leu 
        115                 120                 125             


Tyr Leu Asn Val Trp Thr Pro Tyr Pro Arg Pro Thr Ser Pro Thr Pro 
    130                 135                 140                 


Val Leu Val Trp Ile Tyr Gly Gly Gly Phe Tyr Ser Gly Ala Ser Ser 
145                 150                 155                 160 


Leu Asp Val Tyr Asp Gly Arg Phe Leu Val Gln Ala Glu Arg Thr Val 
                165                 170                 175     


Leu Val Ser Met Asn Tyr Arg Val Gly Ala Phe Gly Phe Leu Ala Leu 
            180                 185                 190         


Pro Gly Ser Arg Glu Ala Pro Gly Asn Val Gly Leu Leu Asp Gln Arg 
        195                 200                 205             


Leu Ala Leu Gln Trp Val Gln Glu Asn Val Ala Ala Phe Gly Gly Asp 
    210                 215                 220                 


Pro Thr Ser Val Thr Leu Phe Gly Glu Ser Ala Gly Ala Ala Ser Val 
225                 230                 235                 240 


Gly Met His Leu Leu Ser Pro Pro Ser Arg Gly Leu Phe His Arg Ala 
                245                 250                 255     


Val Leu Gln Ser Gly Ala Pro Asn Gly Pro Trp Ala Thr Val Gly Met 
            260                 265                 270         


Gly Glu Ala Arg Arg Arg Ala Thr Gln Leu Ala His Leu Val Gly Cys 
        275                 280                 285             


Pro Pro Gly Gly Thr Gly Gly Asn Asp Thr Glu Leu Val Ala Cys Leu 
    290                 295                 300                 


Arg Thr Arg Pro Ala Gln Val Leu Val Asn His Glu Trp His Val Leu 
305                 310                 315                 320 


Pro Gln Glu Ser Val Phe Arg Phe Ser Phe Val Pro Val Val Asp Gly 
                325                 330                 335     


Asp Phe Leu Ser Asp Thr Pro Glu Ala Leu Ile Asn Ala Gly Asp Phe 
            340                 345                 350         


His Gly Leu Gln Val Leu Val Gly Val Val Lys Asp Glu Gly Ser Tyr 
        355                 360                 365             


Phe Leu Val Tyr Gly Ala Pro Gly Phe Ser Lys Asp Asn Glu Ser Leu 
    370                 375                 380                 


Ile Ser Arg Ala Glu Phe Leu Ala Gly Val Arg Val Gly Val Pro Gln 
385                 390                 395                 400 


Val Ser Asp Leu Ala Ala Glu Ala Val Val Leu His Tyr Thr Asp Trp 
                405                 410                 415     


Leu His Pro Glu Asp Pro Ala Arg Leu Arg Glu Ala Leu Ser Asp Val 
            420                 425                 430         


Val Gly Asp His Asn Val Val Cys Pro Val Ala Gln Leu Ala Gly Arg 
        435                 440                 445             


Leu Ala Ala Gln Gly Ala Arg Val Tyr Ala Tyr Val Phe Glu His Arg 
    450                 455                 460                 


Ala Ser Thr Leu Ser Trp Pro Leu Trp Met Gly Val Pro His Gly Tyr 
465                 470                 475                 480 


Glu Ile Glu Phe Ile Phe Gly Ile Pro Leu Asp Pro Ser Arg Asn Tyr 
                485                 490                 495     


Thr Ala Glu Glu Lys Ile Phe Ala Gln Arg Leu Met Arg Tyr Trp Ala 
            500                 505                 510         


Asn Phe Ala Arg Thr Gly Asp Pro Asn Glu Pro Arg Asp Pro Lys Ala 
        515                 520                 525             


Pro Gln Trp Pro Pro Tyr Thr Ala Gly Ala Gln Gln Tyr Val Ser Leu 
    530                 535                 540                 


Asp Leu Arg Pro Leu Glu Val Arg Arg Gly Leu Arg Ala Gln Ala Cys 
545                 550                 555                 560 


Ala Phe Trp Asn Arg Phe Leu Pro Lys Leu Leu Ser Ala Thr Asp Thr 
                565                 570                 575     


Leu Asp Glu Ala Glu Arg Gln Trp Lys Ala Glu Phe His Arg Trp Ser 
            580                 585                 590         


Ser Tyr Met Val His Trp Lys Asn Gln Phe Asp His Tyr Ser Lys Gln 
        595                 600                 605             


Asp Arg Cys Ser Asp Leu 
    610                 


<210>  126
<211>  617
<212>  PRT
<213>  Homo Sapiens

<400>  126

Met Arg Pro Pro Gln Cys Leu Leu His Thr Pro Ser Leu Ala Ser Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Trp Leu Leu Gly Gly Gly Val Gly Ala Glu 
            20                  25                  30          


Gly Arg Glu Asp Ala Glu Leu Leu Val Thr Val Arg Gly Gly Arg Leu 
        35                  40                  45              


Arg Gly Ile Arg Leu Lys Thr Pro Gly Gly Pro Val Ser Ala Phe Leu 
    50                  55                  60                  


Gly Ile Pro Phe Ala Glu Pro Pro Met Gly Pro Arg Arg Phe Leu Pro 
65                  70                  75                  80  


Pro Glu Pro Lys Gln Pro Trp Ser Gly Val Val Asp Ala Thr Thr Phe 
                85                  90                  95      


Gln Ser Val Cys Tyr Gln Tyr Val Asp Thr Leu Tyr Pro Gly Phe Glu 
            100                 105                 110         


Gly Thr Glu Met Trp Asn Pro Asn Arg Glu Leu Ser Glu Asp Cys Leu 
        115                 120                 125             


Tyr Leu Asn Val Trp Thr Pro Tyr Pro Arg Pro Thr Ser Pro Thr Pro 
    130                 135                 140                 


Val Leu Val Trp Ile Tyr Gly Gly Gly Phe Tyr Ser Gly Ala Ser Ser 
145                 150                 155                 160 


Leu Asp Val Tyr Asp Gly Arg Phe Leu Val Gln Ala Glu Arg Thr Val 
                165                 170                 175     


Leu Val Ser Met Asn Tyr Arg Val Gly Ala Phe Gly Phe Leu Ala Leu 
            180                 185                 190         


Pro Gly Ser Arg Glu Ala Pro Gly Asn Val Gly Leu Leu Asp Gln Arg 
        195                 200                 205             


Leu Ala Leu Gln Trp Val Gln Glu Asn Val Ala Ala Phe Gly Gly Asp 
    210                 215                 220                 


Pro Thr Ser Val Thr Leu Phe Gly Glu Ser Ala Gly Ala Ala Ser Val 
225                 230                 235                 240 


Gly Met His Leu Leu Ser Pro Pro Ser Arg Gly Leu Phe His Arg Ala 
                245                 250                 255     


Val Leu Gln Ser Gly Ala Pro Asn Gly Pro Trp Ala Thr Val Gly Met 
            260                 265                 270         


Gly Glu Ala Arg Arg Arg Ala Thr Gln Leu Ala His Leu Val Gly Cys 
        275                 280                 285             


Pro Pro Gly Gly Thr Gly Gly Asn Asp Thr Glu Leu Val Ala Cys Leu 
    290                 295                 300                 


Arg Thr Arg Pro Ala Gln Val Leu Val Asn His Glu Trp His Val Leu 
305                 310                 315                 320 


Pro Gln Glu Ser Val Phe Arg Phe Ser Phe Val Pro Val Val Asp Gly 
                325                 330                 335     


Asp Phe Leu Ser Asp Thr Pro Glu Ala Leu Ile Asn Ala Gly Asp Phe 
            340                 345                 350         


His Gly Leu Gln Val Leu Val Gly Val Val Lys Asp Glu Gly Ser Tyr 
        355                 360                 365             


Phe Leu Val Tyr Gly Ala Pro Gly Phe Ser Lys Asp Asn Glu Ser Leu 
    370                 375                 380                 


Ile Ser Arg Ala Glu Phe Leu Ala Gly Val Arg Val Gly Val Pro Gln 
385                 390                 395                 400 


Val Ser Asp Leu Ala Ala Glu Ala Val Val Leu His Tyr Thr Asp Trp 
                405                 410                 415     


Leu His Pro Glu Asp Pro Ala Arg Leu Arg Glu Ala Leu Ser Asp Val 
            420                 425                 430         


Val Gly Asp His Asn Val Val Cys Pro Val Ala Gln Leu Ala Gly Arg 
        435                 440                 445             


Leu Ala Ala Gln Gly Ala Arg Val Tyr Ala Tyr Val Phe Glu His Arg 
    450                 455                 460                 


Ala Ser Thr Leu Ser Trp Pro Leu Trp Met Gly Val Pro His Gly Tyr 
465                 470                 475                 480 


Glu Ile Glu Phe Ile Phe Gly Ile Pro Leu Asp Pro Ser Arg Asn Tyr 
                485                 490                 495     


Thr Ala Glu Glu Lys Ile Phe Ala Gln Arg Leu Met Arg Tyr Trp Ala 
            500                 505                 510         


Asn Phe Ala Arg Thr Gly Asp Pro Asn Glu Pro Arg Asp Pro Lys Ala 
        515                 520                 525             


Pro Gln Trp Pro Pro Tyr Thr Ala Gly Ala Gln Gln Tyr Val Ser Leu 
    530                 535                 540                 


Asp Leu Arg Pro Leu Glu Val Arg Arg Gly Leu Arg Ala Gln Ala Cys 
545                 550                 555                 560 


Ala Phe Trp Asn Arg Phe Leu Pro Lys Leu Leu Ser Ala Thr Ala Ser 
                565                 570                 575     


Glu Ala Pro Ser Thr Cys Pro Gly Phe Thr His Gly Glu Ala Ala Pro 
            580                 585                 590         


Arg Pro Gly Leu Pro Leu Pro Leu Leu Leu Leu His Gln Leu Leu Leu 
        595                 600                 605             


Leu Phe Leu Ser His Leu Arg Arg Leu 
    610                 615         


<210>  127
<211>  614
<212>  PRT
<213>  Homo Sapiens

<400>  127

Met Arg Pro Pro Gln Cys Leu Leu His Thr Pro Ser Leu Ala Ser Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Trp Leu Leu Gly Gly Gly Val Gly Ala Glu 
            20                  25                  30          


Gly Arg Glu Asp Ala Glu Leu Leu Val Thr Val Arg Gly Gly Arg Leu 
        35                  40                  45              


Arg Gly Ile Arg Leu Lys Thr Pro Gly Gly Pro Val Ser Ala Phe Leu 
    50                  55                  60                  


Gly Ile Pro Phe Ala Glu Pro Pro Met Gly Pro Arg Arg Phe Leu Pro 
65                  70                  75                  80  


Pro Glu Pro Lys Gln Pro Trp Ser Gly Val Val Asp Ala Thr Thr Phe 
                85                  90                  95      


Gln Ser Val Cys Tyr Gln Tyr Val Asp Thr Leu Tyr Pro Gly Phe Glu 
            100                 105                 110         


Gly Thr Glu Met Trp Asn Pro Asn Arg Glu Leu Ser Glu Asp Cys Leu 
        115                 120                 125             


Tyr Leu Asn Val Trp Thr Pro Tyr Pro Arg Pro Thr Ser Pro Thr Pro 
    130                 135                 140                 


Val Leu Val Trp Ile Tyr Gly Gly Gly Phe Tyr Ser Gly Ala Ser Ser 
145                 150                 155                 160 


Leu Asp Val Tyr Asp Gly Arg Phe Leu Val Gln Ala Glu Arg Thr Val 
                165                 170                 175     


Leu Val Ser Met Asn Tyr Arg Val Gly Ala Phe Gly Phe Leu Ala Leu 
            180                 185                 190         


Pro Gly Ser Arg Glu Ala Pro Gly Asn Val Gly Leu Leu Asp Gln Arg 
        195                 200                 205             


Leu Ala Leu Gln Trp Val Gln Glu Asn Val Ala Ala Phe Gly Gly Asp 
    210                 215                 220                 


Pro Thr Ser Val Thr Leu Phe Gly Glu Ser Ala Gly Ala Ala Ser Val 
225                 230                 235                 240 


Gly Met His Leu Leu Ser Pro Pro Ser Arg Gly Leu Phe His Arg Ala 
                245                 250                 255     


Val Leu Gln Ser Gly Ala Pro Asn Gly Pro Trp Ala Thr Val Gly Met 
            260                 265                 270         


Gly Glu Ala Arg Arg Arg Ala Thr Gln Leu Ala His Leu Val Gly Cys 
        275                 280                 285             


Pro Pro Gly Gly Thr Gly Gly Asn Asp Thr Glu Leu Val Ala Cys Leu 
    290                 295                 300                 


Arg Thr Arg Pro Ala Gln Val Leu Val Asn His Glu Trp His Val Leu 
305                 310                 315                 320 


Pro Gln Glu Ser Val Phe Arg Phe Ser Phe Val Pro Val Val Asp Gly 
                325                 330                 335     


Asp Phe Leu Ser Asp Thr Pro Glu Ala Leu Ile Asn Ala Gly Asp Phe 
            340                 345                 350         


His Gly Leu Gln Val Leu Val Gly Val Val Lys Asp Glu Gly Ser Tyr 
        355                 360                 365             


Phe Leu Val Tyr Gly Ala Pro Gly Phe Ser Lys Asp Asn Glu Ser Leu 
    370                 375                 380                 


Ile Ser Arg Ala Glu Phe Leu Ala Gly Val Arg Val Gly Val Pro Gln 
385                 390                 395                 400 


Val Ser Asp Leu Ala Ala Glu Ala Val Val Leu His Tyr Thr Asp Trp 
                405                 410                 415     


Leu His Pro Glu Asp Pro Ala Arg Leu Arg Glu Ala Leu Ser Asp Val 
            420                 425                 430         


Val Gly Asp His Asn Val Val Cys Pro Val Ala Gln Leu Ala Gly Arg 
        435                 440                 445             


Leu Ala Ala Gln Gly Ala Arg Val Tyr Ala Tyr Val Phe Glu His Arg 
    450                 455                 460                 


Ala Ser Thr Leu Ser Trp Pro Leu Trp Met Gly Val Pro His Gly Tyr 
465                 470                 475                 480 


Glu Ile Glu Phe Ile Phe Gly Ile Pro Leu Asp Pro Ser Arg Asn Tyr 
                485                 490                 495     


Thr Ala Glu Glu Lys Ile Phe Ala Gln Arg Leu Met Arg Tyr Trp Ala 
            500                 505                 510         


Asn Phe Ala Arg Thr Gly Asp Pro Asn Glu Pro Arg Asp Pro Lys Ala 
        515                 520                 525             


Pro Gln Trp Pro Pro Tyr Thr Ala Gly Ala Gln Gln Tyr Val Ser Leu 
    530                 535                 540                 


Asp Leu Arg Pro Leu Glu Val Arg Arg Gly Leu Arg Ala Gln Ala Cys 
545                 550                 555                 560 


Ala Phe Trp Asn Arg Phe Leu Pro Lys Leu Leu Ser Ala Thr Asp Thr 
                565                 570                 575     


Leu Asp Glu Ala Glu Arg Gln Trp Lys Ala Glu Phe His Arg Trp Ser 
            580                 585                 590         


Ser Tyr Met Val His Trp Lys Asn Gln Phe Asp His Tyr Ser Lys Gln 
        595                 600                 605             


Asp Arg Cys Ser Asp Leu 
    610                 


<210>  128
<211>  614
<212>  PRT
<213>  Homo Sapiens

<400>  128

Met Arg Pro Pro Gln Cys Leu Leu His Thr Pro Ser Leu Ala Ser Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Trp Leu Leu Gly Gly Gly Val Gly Ala Glu 
            20                  25                  30          


Gly Arg Glu Asp Ala Glu Leu Leu Val Thr Val Arg Gly Gly Arg Leu 
        35                  40                  45              


Arg Gly Ile Arg Leu Lys Thr Pro Gly Gly Pro Val Ser Ala Phe Leu 
    50                  55                  60                  


Gly Ile Pro Phe Ala Glu Pro Pro Met Gly Pro Arg Arg Phe Leu Pro 
65                  70                  75                  80  


Pro Glu Pro Lys Gln Pro Trp Ser Gly Val Val Asp Ala Thr Thr Phe 
                85                  90                  95      


Gln Ser Val Cys Tyr Gln Tyr Val Asp Thr Leu Tyr Pro Gly Phe Glu 
            100                 105                 110         


Gly Thr Glu Met Trp Asn Pro Asn Arg Glu Leu Ser Glu Asp Cys Leu 
        115                 120                 125             


Tyr Leu Asn Val Trp Thr Pro Tyr Pro Arg Pro Thr Ser Pro Thr Pro 
    130                 135                 140                 


Val Leu Val Trp Ile Tyr Gly Gly Gly Phe Tyr Ser Gly Ala Ser Ser 
145                 150                 155                 160 


Leu Asp Val Tyr Asp Gly Arg Phe Leu Val Gln Ala Glu Arg Thr Val 
                165                 170                 175     


Leu Val Ser Met Asn Tyr Arg Val Gly Ala Phe Gly Phe Leu Ala Leu 
            180                 185                 190         


Pro Gly Ser Arg Glu Ala Pro Gly Asn Val Gly Leu Leu Asp Gln Arg 
        195                 200                 205             


Leu Ala Leu Gln Trp Val Gln Glu Asn Val Ala Ala Phe Gly Gly Asp 
    210                 215                 220                 


Pro Thr Ser Val Thr Leu Phe Gly Glu Ser Ala Gly Ala Ala Ser Val 
225                 230                 235                 240 


Gly Met His Leu Leu Ser Pro Pro Ser Arg Gly Leu Phe His Arg Ala 
                245                 250                 255     


Val Leu Gln Ser Gly Ala Pro Asn Gly Pro Trp Ala Thr Val Gly Met 
            260                 265                 270         


Gly Glu Ala Arg Arg Arg Ala Thr Gln Leu Ala His Leu Val Gly Cys 
        275                 280                 285             


Pro Pro Gly Gly Thr Gly Gly Asn Asp Thr Glu Leu Val Ala Cys Leu 
    290                 295                 300                 


Arg Thr Arg Pro Ala Gln Val Leu Val Asn His Glu Trp His Val Leu 
305                 310                 315                 320 


Pro Gln Glu Ser Val Phe Arg Phe Ser Phe Val Pro Val Val Asp Gly 
                325                 330                 335     


Asp Phe Leu Ser Asp Thr Pro Glu Ala Leu Ile Asn Ala Gly Asp Phe 
            340                 345                 350         


His Gly Leu Gln Val Leu Val Gly Val Val Lys Asp Glu Gly Ser Tyr 
        355                 360                 365             


Phe Leu Val Tyr Gly Ala Pro Gly Phe Ser Lys Asp Asn Glu Ser Leu 
    370                 375                 380                 


Ile Ser Arg Ala Glu Phe Leu Ala Gly Val Arg Val Gly Val Pro Gln 
385                 390                 395                 400 


Val Ser Asp Leu Ala Ala Glu Ala Val Val Leu His Tyr Thr Asp Trp 
                405                 410                 415     


Leu His Pro Glu Asp Pro Ala Arg Leu Arg Glu Ala Leu Ser Asp Val 
            420                 425                 430         


Val Gly Asp His Asn Val Val Cys Pro Val Ala Gln Leu Ala Gly Arg 
        435                 440                 445             


Leu Ala Ala Gln Gly Ala Arg Val Tyr Ala Tyr Val Phe Glu His Arg 
    450                 455                 460                 


Ala Ser Thr Leu Ser Trp Pro Leu Trp Met Gly Val Pro His Gly Tyr 
465                 470                 475                 480 


Glu Ile Glu Phe Ile Phe Gly Ile Pro Leu Asp Pro Ser Arg Asn Tyr 
                485                 490                 495     


Thr Ala Glu Glu Lys Ile Phe Ala Gln Arg Leu Met Arg Tyr Trp Ala 
            500                 505                 510         


Asn Phe Ala Arg Thr Gly Asp Pro Asn Glu Pro Arg Asp Pro Lys Ala 
        515                 520                 525             


Pro Gln Trp Pro Pro Tyr Thr Ala Gly Ala Gln Gln Tyr Val Ser Leu 
    530                 535                 540                 


Asp Leu Arg Pro Leu Glu Val Arg Arg Gly Leu Arg Ala Gln Ala Cys 
545                 550                 555                 560 


Ala Phe Trp Asn Arg Phe Leu Pro Lys Leu Leu Ser Ala Thr Asp Thr 
                565                 570                 575     


Leu Asp Glu Ala Glu Arg Gln Trp Lys Ala Glu Phe His Arg Trp Ser 
            580                 585                 590         


Ser Tyr Met Val His Trp Lys Asn Gln Phe Asp His Tyr Ser Lys Gln 
        595                 600                 605             


Asp Arg Cys Ser Asp Leu 
    610                 


<210>  129
<211>  617
<212>  PRT
<213>  Homo Sapiens

<400>  129

Met Arg Pro Pro Gln Cys Leu Leu His Thr Pro Ser Leu Ala Ser Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Trp Leu Leu Gly Gly Gly Val Gly Ala Glu 
            20                  25                  30          


Gly Arg Glu Asp Ala Glu Leu Leu Val Thr Val Arg Gly Gly Arg Leu 
        35                  40                  45              


Arg Gly Ile Arg Leu Lys Thr Pro Gly Gly Pro Val Ser Ala Phe Leu 
    50                  55                  60                  


Gly Ile Pro Phe Ala Glu Pro Pro Met Gly Pro Arg Arg Phe Leu Pro 
65                  70                  75                  80  


Pro Glu Pro Lys Gln Pro Trp Ser Gly Val Val Asp Ala Thr Thr Phe 
                85                  90                  95      


Gln Ser Val Cys Tyr Gln Tyr Val Asp Thr Leu Tyr Pro Gly Phe Glu 
            100                 105                 110         


Gly Thr Glu Met Trp Asn Pro Asn Arg Glu Leu Ser Glu Asp Cys Leu 
        115                 120                 125             


Tyr Leu Asn Val Trp Thr Pro Tyr Pro Arg Pro Thr Ser Pro Thr Pro 
    130                 135                 140                 


Val Leu Val Trp Ile Tyr Gly Gly Gly Phe Tyr Ser Gly Ala Ser Ser 
145                 150                 155                 160 


Leu Asp Val Tyr Asp Gly Arg Phe Leu Val Gln Ala Glu Arg Thr Val 
                165                 170                 175     


Leu Val Ser Met Asn Tyr Arg Val Gly Ala Phe Gly Phe Leu Ala Leu 
            180                 185                 190         


Pro Gly Ser Arg Glu Ala Pro Gly Asn Val Gly Leu Leu Asp Gln Arg 
        195                 200                 205             


Leu Ala Leu Gln Trp Val Gln Glu Asn Val Ala Ala Phe Gly Gly Asp 
    210                 215                 220                 


Pro Thr Ser Val Thr Leu Phe Gly Glu Ser Ala Gly Ala Ala Ser Val 
225                 230                 235                 240 


Gly Met His Leu Leu Ser Pro Pro Ser Arg Gly Leu Phe His Arg Ala 
                245                 250                 255     


Val Leu Gln Ser Gly Ala Pro Asn Gly Pro Trp Ala Thr Val Gly Met 
            260                 265                 270         


Gly Glu Ala Arg Arg Arg Ala Thr Gln Leu Ala His Leu Val Gly Cys 
        275                 280                 285             


Pro Pro Gly Gly Thr Gly Gly Asn Asp Thr Glu Leu Val Ala Cys Leu 
    290                 295                 300                 


Arg Thr Arg Pro Ala Gln Val Leu Val Asn His Glu Trp His Val Leu 
305                 310                 315                 320 


Pro Gln Glu Ser Val Phe Arg Phe Ser Phe Val Pro Val Val Asp Gly 
                325                 330                 335     


Asp Phe Leu Ser Asp Thr Pro Glu Ala Leu Ile Asn Ala Gly Asp Phe 
            340                 345                 350         


His Gly Leu Gln Val Leu Val Gly Val Val Lys Asp Glu Gly Ser Tyr 
        355                 360                 365             


Phe Leu Val Tyr Gly Ala Pro Gly Phe Ser Lys Asp Asn Glu Ser Leu 
    370                 375                 380                 


Ile Ser Arg Ala Glu Phe Leu Ala Gly Val Arg Val Gly Val Pro Gln 
385                 390                 395                 400 


Val Ser Asp Leu Ala Ala Glu Ala Val Val Leu His Tyr Thr Asp Trp 
                405                 410                 415     


Leu His Pro Glu Asp Pro Ala Arg Leu Arg Glu Ala Leu Ser Asp Val 
            420                 425                 430         


Val Gly Asp His Asn Val Val Cys Pro Val Ala Gln Leu Ala Gly Arg 
        435                 440                 445             


Leu Ala Ala Gln Gly Ala Arg Val Tyr Ala Tyr Val Phe Glu His Arg 
    450                 455                 460                 


Ala Ser Thr Leu Ser Trp Pro Leu Trp Met Gly Val Pro His Gly Tyr 
465                 470                 475                 480 


Glu Ile Glu Phe Ile Phe Gly Ile Pro Leu Asp Pro Ser Arg Asn Tyr 
                485                 490                 495     


Thr Ala Glu Glu Lys Ile Phe Ala Gln Arg Leu Met Arg Tyr Trp Ala 
            500                 505                 510         


Asn Phe Ala Arg Thr Gly Asp Pro Asn Glu Pro Arg Asp Pro Lys Ala 
        515                 520                 525             


Pro Gln Trp Pro Pro Tyr Thr Ala Gly Ala Gln Gln Tyr Val Ser Leu 
    530                 535                 540                 


Asp Leu Arg Pro Leu Glu Val Arg Arg Gly Leu Arg Ala Gln Ala Cys 
545                 550                 555                 560 


Ala Phe Trp Asn Arg Phe Leu Pro Lys Leu Leu Ser Ala Thr Ala Ser 
                565                 570                 575     


Glu Ala Pro Ser Thr Cys Pro Gly Phe Thr His Gly Glu Ala Ala Pro 
            580                 585                 590         


Arg Pro Gly Leu Pro Leu Pro Leu Leu Leu Leu His Gln Leu Leu Leu 
        595                 600                 605             


Leu Phe Leu Ser His Leu Arg Arg Leu 
    610                 615         


<210>  130
<211>  435
<212>  PRT
<213>  Homo Sapiens

<400>  130

Met Arg Pro Pro Gln Cys Leu Leu His Thr Pro Ser Leu Ala Ser Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Trp Leu Leu Gly Gly Gly Val Gly Ala Glu 
            20                  25                  30          


Gly Arg Glu Asp Ala Glu Leu Leu Val Thr Val Arg Gly Gly Arg Leu 
        35                  40                  45              


Arg Gly Ile Arg Leu Lys Thr Pro Gly Gly Pro Val Ser Ala Phe Leu 
    50                  55                  60                  


Gly Ile Pro Phe Ala Glu Pro Pro Met Gly Pro Arg Arg Phe Leu Pro 
65                  70                  75                  80  


Pro Glu Pro Lys Gln Pro Trp Ser Gly Val Val Asp Ala Thr Thr Phe 
                85                  90                  95      


Gln Ser Val Cys Tyr Gln Tyr Val Asp Thr Leu Tyr Pro Gly Phe Glu 
            100                 105                 110         


Gly Thr Glu Met Trp Asn Pro Asn Arg Glu Leu Ser Glu Asp Cys Leu 
        115                 120                 125             


Tyr Leu Asn Val Trp Thr Pro Tyr Pro Arg Pro Thr Ser Pro Thr Pro 
    130                 135                 140                 


Val Leu Val Trp Ile Tyr Gly Gly Gly Phe Tyr Ser Gly Ala Ser Ser 
145                 150                 155                 160 


Leu Asp Val Tyr Asp Gly Arg Phe Leu Val Gln Ala Glu Arg Thr Val 
                165                 170                 175     


Leu Val Ser Met Asn Tyr Arg Val Gly Ala Phe Gly Phe Leu Ala Leu 
            180                 185                 190         


Pro Gly Ser Arg Glu Ala Pro Gly Asn Val Gly Leu Leu Asp Gln Arg 
        195                 200                 205             


Leu Ala Leu Gln Trp Val Gln Glu Asn Val Ala Ala Phe Gly Gly Asp 
    210                 215                 220                 


Pro Thr Ser Val Thr Leu Phe Gly Glu Ser Ala Gly Ala Ala Ser Val 
225                 230                 235                 240 


Gly Met His Leu Leu Ser Pro Pro Ser Arg Gly Leu Phe His Arg Ala 
                245                 250                 255     


Val Leu Gln Ser Gly Ala Pro Asn Gly Pro Trp Ala Thr Val Gly Met 
            260                 265                 270         


Gly Glu Ala Arg Arg Arg Ala Thr Gln Leu Ala His Leu Val Gly Cys 
        275                 280                 285             


Pro Pro Gly Gly Thr Gly Gly Asn Asp Thr Glu Leu Val Ala Cys Leu 
    290                 295                 300                 


Arg Thr Arg Pro Ala Gln Val Leu Val Asn His Glu Trp His Val Leu 
305                 310                 315                 320 


Pro Gln Glu Ser Val Phe Arg Phe Ser Phe Val Pro Val Val Asp Gly 
                325                 330                 335     


Asp Phe Leu Ser Asp Thr Pro Glu Ala Leu Ile Asn Ala Gly Asp Phe 
            340                 345                 350         


His Gly Leu Gln Val Leu Val Gly Val Val Lys Asp Glu Gly Ser Tyr 
        355                 360                 365             


Phe Leu Val Tyr Gly Ala Pro Gly Phe Ser Lys Asp Asn Glu Ser Leu 
    370                 375                 380                 


Ile Ser Arg Ala Glu Phe Leu Ala Gly Thr Arg Ser Thr Arg Arg Ser 
385                 390                 395                 400 


Ala Ser Gly Arg Pro Ser Ser Thr Ala Gly Ala Pro Thr Trp Cys Thr 
                405                 410                 415     


Gly Arg Thr Ser Ser Thr Thr Thr Ala Ser Arg Ile Ala Ala Gln Thr 
            420                 425                 430         


Cys Asp Pro 
        435 


<210>  131
<211>  398
<212>  PRT
<213>  Homo Sapiens

<400>  131

Met Arg Pro Pro Gln Cys Leu Leu His Thr Pro Ser Leu Ala Ser Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Trp Leu Leu Gly Gly Gly Val Gly Ala Glu 
            20                  25                  30          


Gly Arg Glu Asp Ala Glu Leu Leu Val Thr Val Arg Gly Gly Arg Leu 
        35                  40                  45              


Arg Gly Ile Arg Leu Lys Thr Pro Gly Gly Pro Val Ser Ala Phe Leu 
    50                  55                  60                  


Gly Ile Pro Phe Ala Glu Pro Pro Met Gly Pro Arg Arg Phe Leu Pro 
65                  70                  75                  80  


Pro Glu Pro Lys Gln Pro Trp Ser Gly Val Val Asp Ala Thr Thr Phe 
                85                  90                  95      


Gln Ser Val Cys Tyr Gln Tyr Val Asp Thr Leu Tyr Pro Gly Phe Glu 
            100                 105                 110         


Gly Thr Glu Met Trp Asn Pro Asn Arg Glu Leu Ser Glu Asp Cys Leu 
        115                 120                 125             


Tyr Leu Asn Val Trp Thr Pro Tyr Pro Arg Pro Thr Ser Pro Thr Pro 
    130                 135                 140                 


Val Leu Val Trp Ile Tyr Gly Gly Gly Phe Tyr Ser Gly Ala Ser Ser 
145                 150                 155                 160 


Leu Asp Val Tyr Asp Gly Arg Phe Leu Val Gln Ala Glu Arg Thr Val 
                165                 170                 175     


Leu Val Ser Met Asn Tyr Arg Val Gly Ala Phe Gly Phe Leu Ala Leu 
            180                 185                 190         


Pro Gly Ser Arg Glu Ala Pro Gly Asn Val Gly Leu Leu Asp Gln Arg 
        195                 200                 205             


Leu Ala Leu Gln Trp Val Gln Glu Asn Val Ala Ala Phe Gly Gly Asp 
    210                 215                 220                 


Pro Thr Ser Val Thr Leu Phe Gly Glu Ser Ala Gly Ala Ala Ser Val 
225                 230                 235                 240 


Gly Met His Leu Leu Ser Pro Pro Ser Arg Gly Leu Phe His Arg Ala 
                245                 250                 255     


Val Leu Gln Ser Gly Ala Pro Asn Gly Pro Trp Ala Thr Val Gly Met 
            260                 265                 270         


Gly Glu Ala Arg Arg Arg Ala Thr Gln Leu Ala His Leu Val Gly Cys 
        275                 280                 285             


Pro Pro Gly Gly Thr Gly Gly Asn Asp Thr Glu Leu Val Ala Cys Leu 
    290                 295                 300                 


Arg Thr Arg Pro Ala Gln Val Leu Val Asn His Glu Trp His Val Leu 
305                 310                 315                 320 


Pro Gln Glu Ser Val Phe Arg Phe Ser Phe Val Pro Val Val Asp Gly 
                325                 330                 335     


Asp Phe Leu Ser Asp Thr Pro Glu Ala Leu Ile Asn Ala Gly Asp Phe 
            340                 345                 350         


His Gly Leu Gln Thr Arg Ser Thr Arg Arg Ser Ala Ser Gly Arg Pro 
        355                 360                 365             


Ser Ser Thr Ala Gly Ala Pro Thr Trp Cys Thr Gly Arg Thr Ser Ser 
    370                 375                 380                 


Thr Thr Thr Ala Ser Arg Ile Ala Ala Gln Thr Cys Asp Pro 
385                 390                 395             


<210>  132
<211>  526
<212>  PRT
<213>  Homo Sapiens

<400>  132

Met Arg Pro Pro Gln Cys Leu Leu His Thr Pro Ser Leu Ala Ser Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Trp Leu Leu Gly Gly Gly Val Gly Ala Glu 
            20                  25                  30          


Gly Arg Glu Asp Ala Glu Leu Leu Val Thr Val Arg Gly Gly Arg Leu 
        35                  40                  45              


Arg Gly Ile Arg Leu Lys Thr Pro Gly Gly Pro Val Ser Ala Phe Leu 
    50                  55                  60                  


Gly Ile Pro Phe Ala Glu Pro Pro Met Gly Pro Arg Arg Phe Leu Pro 
65                  70                  75                  80  


Pro Glu Pro Lys Gln Pro Trp Ser Gly Val Val Asp Ala Thr Thr Phe 
                85                  90                  95      


Gln Ser Val Cys Tyr Gln Tyr Val Asp Thr Leu Tyr Pro Gly Phe Glu 
            100                 105                 110         


Gly Thr Glu Met Trp Asn Pro Asn Arg Glu Leu Ser Glu Asp Cys Leu 
        115                 120                 125             


Tyr Leu Asn Val Trp Thr Pro Tyr Pro Arg Pro Thr Ser Pro Thr Pro 
    130                 135                 140                 


Val Leu Val Trp Ile Tyr Gly Gly Gly Phe Tyr Ser Gly Ala Ser Ser 
145                 150                 155                 160 


Leu Asp Val Tyr Asp Gly Arg Phe Leu Val Gln Ala Glu Arg Thr Val 
                165                 170                 175     


Leu Val Ser Met Asn Tyr Arg Val Gly Ala Phe Gly Phe Leu Ala Leu 
            180                 185                 190         


Pro Gly Ser Arg Glu Ala Pro Gly Asn Val Gly Leu Leu Asp Gln Arg 
        195                 200                 205             


Leu Ala Leu Gln Trp Val Gln Glu Asn Val Ala Ala Phe Gly Gly Asp 
    210                 215                 220                 


Pro Thr Ser Val Thr Leu Phe Gly Glu Ser Ala Gly Ala Ala Ser Val 
225                 230                 235                 240 


Gly Met His Leu Leu Ser Pro Pro Ser Arg Gly Leu Phe His Arg Ala 
                245                 250                 255     


Val Leu Gln Ser Gly Ala Pro Asn Gly Pro Trp Ala Thr Val Gly Met 
            260                 265                 270         


Gly Glu Ala Arg Arg Arg Ala Thr Gln Leu Ala His Leu Val Gly Cys 
        275                 280                 285             


Pro Pro Gly Gly Thr Gly Gly Asn Asp Thr Glu Leu Val Ala Cys Leu 
    290                 295                 300                 


Arg Thr Arg Pro Ala Gln Val Leu Val Asn His Glu Trp His Val Leu 
305                 310                 315                 320 


Pro Gln Glu Ser Val Phe Arg Phe Ser Phe Val Pro Val Val Asp Gly 
                325                 330                 335     


Asp Phe Leu Ser Asp Thr Pro Glu Ala Leu Ile Asn Ala Gly Asp Phe 
            340                 345                 350         


His Gly Leu Gln Leu Ala Gly Arg Leu Ala Ala Gln Gly Ala Arg Val 
        355                 360                 365             


Tyr Ala Tyr Val Phe Glu His Arg Ala Ser Thr Leu Ser Trp Pro Leu 
    370                 375                 380                 


Trp Met Gly Val Pro His Gly Tyr Glu Ile Glu Phe Ile Phe Gly Ile 
385                 390                 395                 400 


Pro Leu Asp Pro Ser Arg Asn Tyr Thr Ala Glu Glu Lys Ile Phe Ala 
                405                 410                 415     


Gln Arg Leu Met Arg Tyr Trp Ala Asn Phe Ala Arg Thr Gly Asp Pro 
            420                 425                 430         


Asn Glu Pro Arg Asp Pro Lys Ala Pro Gln Trp Pro Pro Tyr Thr Ala 
        435                 440                 445             


Gly Ala Gln Gln Tyr Val Ser Leu Asp Leu Arg Pro Leu Glu Val Arg 
    450                 455                 460                 


Arg Gly Leu Arg Ala Gln Ala Cys Ala Phe Trp Asn Arg Phe Leu Pro 
465                 470                 475                 480 


Lys Leu Leu Ser Ala Thr Asp Thr Leu Asp Glu Ala Glu Arg Gln Trp 
                485                 490                 495     


Lys Ala Glu Phe His Arg Trp Ser Ser Tyr Met Val His Trp Lys Asn 
            500                 505                 510         


Gln Phe Asp His Tyr Ser Lys Gln Asp Arg Cys Ser Asp Leu 
        515                 520                 525     


<210>  133
<211>  359
<212>  PRT
<213>  Homo Sapiens

<400>  133

Met Arg Pro Pro Gln Cys Leu Leu His Thr Pro Ser Leu Ala Ser Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Trp Leu Leu Gly Gly Gly Val Gly Ala Glu 
            20                  25                  30          


Gly Arg Glu Asp Ala Glu Leu Leu Val Thr Val Arg Gly Gly Arg Leu 
        35                  40                  45              


Arg Gly Ile Arg Leu Lys Thr Pro Gly Gly Pro Val Ser Ala Phe Leu 
    50                  55                  60                  


Gly Ile Pro Phe Ala Glu Pro Pro Met Gly Pro Arg Arg Phe Leu Pro 
65                  70                  75                  80  


Pro Glu Pro Lys Gln Pro Trp Ser Gly Val Val Asp Ala Thr Thr Phe 
                85                  90                  95      


Gln Ser Val Cys Tyr Gln Tyr Val Asp Thr Leu Tyr Pro Gly Phe Glu 
            100                 105                 110         


Gly Thr Glu Met Trp Asn Pro Asn Arg Glu Leu Ser Glu Asp Cys Leu 
        115                 120                 125             


Tyr Leu Asn Val Trp Thr Pro Tyr Pro Arg Pro Thr Ser Pro Thr Pro 
    130                 135                 140                 


Val Leu Val Trp Ile Tyr Gly Gly Gly Phe Tyr Ser Gly Ala Ser Ser 
145                 150                 155                 160 


Leu Asp Val Tyr Asp Gly Arg Phe Leu Val Gln Ala Glu Arg Thr Val 
                165                 170                 175     


Leu Val Ser Met Asn Tyr Arg Val Gly Ala Phe Gly Phe Leu Ala Leu 
            180                 185                 190         


Pro Gly Ser Arg Glu Ala Pro Gly Asn Val Gly Leu Leu Asp Gln Arg 
        195                 200                 205             


Leu Ala Leu Gln Trp Val Gln Glu Asn Val Ala Ala Phe Gly Gly Asp 
    210                 215                 220                 


Pro Thr Ser Val Thr Leu Phe Gly Glu Ser Ala Gly Ala Ala Ser Val 
225                 230                 235                 240 


Gly Met His Leu Leu Ser Pro Pro Ser Arg Gly Leu Phe His Arg Ala 
                245                 250                 255     


Val Leu Gln Ser Gly Ala Pro Asn Gly Pro Trp Ala Thr Val Gly Met 
            260                 265                 270         


Gly Glu Ala Arg Arg Arg Ala Thr Gln Leu Ala His Leu Val Gly Cys 
        275                 280                 285             


Pro Pro Gly Gly Thr Gly Gly Asn Asp Thr Glu Leu Val Ala Cys Leu 
    290                 295                 300                 


Arg Thr Arg Pro Ala Gln Val Leu Val Asn His Glu Trp His Val Leu 
305                 310                 315                 320 


Pro Gln Glu Ser Val Phe Arg Phe Ser Phe Val Pro Val Val Asp Gly 
                325                 330                 335     


Asp Phe Leu Ser Asp Thr Pro Glu Ala Leu Ile Asn Ala Gly Asp Phe 
            340                 345                 350         


His Gly Leu Gln Gly Ser Gln 
        355                 


<210>  134
<211>  403
<212>  PRT
<213>  Homo Sapiens

<400>  134

Met Arg Pro Pro Gln Cys Leu Leu His Thr Pro Ser Leu Ala Ser Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Trp Leu Leu Gly Gly Gly Val Gly Ala Glu 
            20                  25                  30          


Gly Arg Glu Asp Ala Glu Leu Leu Val Thr Val Arg Gly Gly Arg Leu 
        35                  40                  45              


Arg Gly Ile Arg Leu Lys Thr Pro Gly Gly Pro Val Ser Ala Phe Leu 
    50                  55                  60                  


Gly Ile Pro Phe Ala Glu Pro Pro Met Gly Pro Arg Arg Phe Leu Pro 
65                  70                  75                  80  


Pro Glu Pro Lys Gln Pro Trp Ser Gly Val Val Asp Ala Thr Thr Phe 
                85                  90                  95      


Gln Ser Val Cys Tyr Gln Tyr Val Asp Thr Leu Tyr Pro Gly Phe Glu 
            100                 105                 110         


Gly Thr Glu Met Trp Asn Pro Asn Arg Glu Leu Ser Glu Asp Cys Leu 
        115                 120                 125             


Tyr Leu Asn Val Trp Thr Pro Tyr Pro Arg Pro Thr Ser Pro Thr Pro 
    130                 135                 140                 


Val Leu Val Trp Ile Tyr Gly Gly Gly Phe Tyr Ser Gly Ala Ser Ser 
145                 150                 155                 160 


Leu Asp Val Tyr Asp Gly Arg Phe Leu Val Gln Ala Glu Arg Thr Val 
                165                 170                 175     


Leu Val Ser Met Asn Tyr Arg Val Gly Ala Phe Gly Phe Leu Ala Leu 
            180                 185                 190         


Pro Gly Ser Arg Glu Ala Pro Gly Asn Val Gly Leu Leu Asp Gln Arg 
        195                 200                 205             


Leu Ala Leu Gln Trp Val Gln Glu Asn Val Ala Ala Phe Gly Gly Asp 
    210                 215                 220                 


Pro Thr Ser Val Thr Leu Phe Gly Glu Ser Ala Gly Ala Ala Ser Val 
225                 230                 235                 240 


Gly Met His Leu Leu Ser Pro Pro Ser Arg Gly Leu Phe His Arg Ala 
                245                 250                 255     


Val Leu Gln Ser Gly Ala Pro Asn Gly Pro Trp Ala Thr Val Gly Met 
            260                 265                 270         


Gly Glu Ala Arg Arg Arg Ala Thr Gln Leu Ala His Leu Val Gly Cys 
        275                 280                 285             


Pro Pro Gly Gly Thr Gly Gly Asn Asp Thr Glu Leu Val Ala Cys Leu 
    290                 295                 300                 


Arg Thr Arg Pro Ala Gln Val Leu Val Asn His Glu Trp His Val Leu 
305                 310                 315                 320 


Pro Gln Glu Ser Val Phe Arg Phe Ser Phe Val Pro Val Val Asp Gly 
                325                 330                 335     


Asp Phe Leu Ser Asp Thr Pro Glu Ala Leu Ile Asn Ala Gly Asp Phe 
            340                 345                 350         


His Gly Leu Gln Val Leu Val Gly Val Val Lys Asp Glu Gly Ser Tyr 
        355                 360                 365             


Phe Leu Val Tyr Gly Ala Pro Gly Phe Ser Lys Asp Asn Glu Ser Leu 
    370                 375                 380                 


Ile Ser Arg Ala Glu Phe Leu Ala Gly Val Arg Val Gly Val Pro Gln 
385                 390                 395                 400 


Gly Ser Gln 
            


<210>  135
<211>  391
<212>  PRT
<213>  Homo Sapiens

<400>  135

Met Ala Gly Lys Arg Ser Gly Trp Ser Arg Ala Ala Leu Leu Gln Leu 
1               5                   10                  15      


Leu Leu Gly Val Asn Leu Val Val Met Pro Pro Thr Arg Ala Arg Ser 
            20                  25                  30          


Leu Arg Phe Val Thr Leu Glu Gly Met Leu Gln His Trp Glu Leu Gly 
        35                  40                  45              


Gln Ala Leu Arg Gln Arg Tyr His Gly Phe Leu Asn Thr Ser Tyr His 
    50                  55                  60                  


Arg Gln Glu Val Tyr Val Arg Ser Thr Asp Phe Asp Arg Thr Leu Met 
65                  70                  75                  80  


Ser Ala Glu Ala Asn Leu Ala Gly Leu Phe Pro Pro Asn Gly Met Gln 
                85                  90                  95      


Arg Phe Asn Pro Asn Ile Ser Trp Gln Pro Ile Pro Val His Thr Val 
            100                 105                 110         


Pro Ile Thr Glu Asp Arg Leu Leu Lys Phe Pro Leu Gly Pro Cys Pro 
        115                 120                 125             


Arg Tyr Glu Gln Leu Gln Asn Glu Thr Arg Gln Thr Pro Glu Tyr Gln 
    130                 135                 140                 


Asn Glu Ser Ser Arg Asn Ala Gln Phe Leu Asp Met Val Ala Asn Glu 
145                 150                 155                 160 


Thr Gly Leu Thr Asp Leu Thr Leu Glu Thr Val Trp Asn Val Tyr Asp 
                165                 170                 175     


Thr Leu Phe Cys Glu Gln Thr His Gly Leu Arg Leu Pro Pro Trp Ala 
            180                 185                 190         


Ser Pro Gln Thr Met Gln Arg Leu Ser Arg Leu Lys Asp Phe Ser Phe 
        195                 200                 205             


Arg Phe Leu Phe Gly Ile Tyr Gln Gln Ala Glu Lys Ala Arg Leu Gln 
    210                 215                 220                 


Gly Gly Val Leu Leu Ala Gln Ile Arg Lys Asn Leu Thr Leu Met Ala 
225                 230                 235                 240 


Thr Thr Ser Gln Leu Pro Lys Leu Leu Val Tyr Ser Ala His Asp Thr 
                245                 250                 255     


Thr Leu Val Ala Leu Gln Met Ala Leu Asp Val Tyr Asn Gly Glu Gln 
            260                 265                 270         


Ala Pro Tyr Ala Ser Cys His Ile Phe Glu Leu Tyr Gln Glu Asp Ser 
        275                 280                 285             


Gly Asn Phe Ser Val Glu Met Tyr Phe Arg Asn Glu Ser Asp Lys Ala 
    290                 295                 300                 


Pro Trp Pro Leu Ser Leu Pro Gly Cys Pro His Arg Cys Pro Leu Gln 
305                 310                 315                 320 


Asp Phe Leu Arg Leu Thr Glu Pro Val Val Pro Lys Asp Trp Gln Gln 
                325                 330                 335     


Glu Cys Gln Leu Ala Ser Gly Pro Ala Asp Thr Glu Val Ile Val Ala 
            340                 345                 350         


Leu Ala Val Cys Gly Ser Ile Leu Phe Leu Leu Ile Val Leu Leu Leu 
        355                 360                 365             


Thr Val Leu Phe Arg Met Gln Ala Gln Pro Pro Gly Tyr Arg His Val 
    370                 375                 380                 


Ala Asp Gly Glu Asp His Ala 
385                 390     


<210>  136
<211>  151
<212>  PRT
<213>  Homo Sapiens

<400>  136

Met Ala Gly Lys Arg Ser Gly Trp Ser Arg Ala Ala Leu Leu Gln Leu 
1               5                   10                  15      


Leu Leu Gly Val Asn Leu Val Val Met Pro Pro Thr Arg Ala Arg Ser 
            20                  25                  30          


Leu Arg Phe Val Thr Leu Leu Tyr Arg His Gly Asp Arg Ser Pro Val 
        35                  40                  45              


Lys Thr Tyr Pro Lys Asp Pro Tyr Gln Glu Glu Glu Trp Pro Gln Gly 
    50                  55                  60                  


Phe Gly Gln Leu Thr Lys Glu Gly Met Leu Gln His Trp Glu Leu Gly 
65                  70                  75                  80  


Gln Ala Leu Arg Gln Arg Tyr His Gly Phe Leu Asn Thr Ser Tyr His 
                85                  90                  95      


Arg Gln Glu Val Tyr Val Arg Ser Thr Asp Phe Asp Arg Thr Leu Met 
            100                 105                 110         


Ser Ala Glu Ala Asn Leu Ala Gly Leu Phe Pro Pro Asn Gly Met Gln 
        115                 120                 125             


Arg Phe Asn Pro Asn Ile Ser Trp Gln Pro Ile Pro Val His Thr Val 
    130                 135                 140                 


Pro Ile Thr Glu Asp Arg Asp 
145                 150     


<210>  137
<211>  423
<212>  PRT
<213>  Homo Sapiens

<400>  137

Met Ala Gly Lys Arg Ser Gly Trp Ser Arg Ala Ala Leu Leu Gln Leu 
1               5                   10                  15      


Leu Leu Gly Val Asn Leu Val Val Met Pro Pro Thr Arg Ala Arg Ser 
            20                  25                  30          


Leu Arg Phe Val Thr Leu Leu Tyr Arg His Gly Asp Arg Ser Pro Val 
        35                  40                  45              


Lys Thr Tyr Pro Lys Asp Pro Tyr Gln Glu Glu Glu Trp Pro Gln Gly 
    50                  55                  60                  


Phe Gly Gln Leu Thr Lys Glu Gly Met Leu Gln His Trp Glu Leu Gly 
65                  70                  75                  80  


Gln Ala Leu Arg Gln Arg Tyr His Gly Phe Leu Asn Thr Ser Tyr His 
                85                  90                  95      


Arg Gln Glu Val Tyr Val Arg Ser Thr Asp Phe Asp Arg Thr Leu Met 
            100                 105                 110         


Ser Ala Glu Ala Asn Leu Ala Gly Leu Phe Pro Pro Asn Gly Met Gln 
        115                 120                 125             


Arg Phe Asn Pro Asn Ile Ser Trp Gln Pro Ile Pro Val His Thr Val 
    130                 135                 140                 


Pro Ile Thr Glu Asp Arg Leu Leu Lys Phe Pro Leu Gly Pro Cys Pro 
145                 150                 155                 160 


Arg Tyr Glu Gln Leu Gln Asn Glu Thr Arg Gln Thr Pro Glu Tyr Gln 
                165                 170                 175     


Asn Glu Ser Ser Arg Asn Ala Gln Phe Leu Asp Met Val Ala Asn Glu 
            180                 185                 190         


Thr Gly Leu Thr Asp Leu Thr Leu Glu Thr Val Trp Asn Val Tyr Asp 
        195                 200                 205             


Thr Leu Phe Cys Glu Gln Thr His Gly Leu Arg Leu Pro Pro Trp Ala 
    210                 215                 220                 


Ser Pro Gln Thr Met Gln Arg Leu Ser Arg Leu Lys Asp Phe Ser Phe 
225                 230                 235                 240 


Arg Phe Leu Phe Gly Ile Tyr Gln Gln Ala Glu Lys Ala Arg Leu Gln 
                245                 250                 255     


Gly Gly Val Leu Leu Ala Gln Ile Arg Lys Asn Leu Thr Leu Met Ala 
            260                 265                 270         


Thr Thr Ser Gln Leu Pro Lys Leu Leu Val Tyr Ser Ala His Asp Thr 
        275                 280                 285             


Thr Leu Val Ala Leu Gln Met Ala Leu Asp Val Tyr Asn Gly Glu Gln 
    290                 295                 300                 


Ala Pro Tyr Ala Ser Cys His Ile Phe Glu Leu Tyr Gln Glu Asp Ser 
305                 310                 315                 320 


Gly Asn Phe Ser Val Glu Met Tyr Phe Arg Asn Glu Ser Asp Lys Ala 
                325                 330                 335     


Pro Trp Pro Leu Ser Leu Pro Gly Cys Pro His Arg Cys Pro Leu Gln 
            340                 345                 350         


Asp Phe Leu Arg Leu Thr Glu Pro Val Val Pro Lys Asp Trp Gln Gln 
        355                 360                 365             


Glu Cys Gln Leu Ala Ser Gly Pro Ala Asp Thr Glu Val Ile Val Ala 
    370                 375                 380                 


Leu Ala Val Cys Gly Ser Ile Leu Phe Leu Leu Ile Val Leu Leu Leu 
385                 390                 395                 400 


Thr Val Leu Phe Arg Met Gln Ala Gln Pro Pro Gly Tyr Arg His Val 
                405                 410                 415     


Ala Asp Gly Glu Asp His Ala 
            420             


<210>  138
<211>  162
<212>  PRT
<213>  Homo Sapiens

<400>  138

Met Ala Gly Lys Arg Ser Gly Trp Ser Arg Ala Ala Leu Leu Gln Leu 
1               5                   10                  15      


Leu Leu Gly Val Asn Leu Val Val Met Pro Pro Thr Arg Ala Arg Ser 
            20                  25                  30          


Leu Arg Phe Val Thr Leu Leu Tyr Arg His Gly Asp Arg Ser Pro Val 
        35                  40                  45              


Lys Thr Tyr Pro Lys Asp Pro Tyr Gln Glu Glu Glu Trp Pro Gln Gly 
    50                  55                  60                  


Phe Gly Gln Leu Thr Lys Glu Gly Met Leu Gln His Trp Glu Leu Gly 
65                  70                  75                  80  


Gln Ala Leu Arg Gln Arg Tyr His Gly Phe Leu Asn Thr Ser Tyr His 
                85                  90                  95      


Arg Gln Glu Val Tyr Val Arg Ser Thr Asp Phe Asp Arg Thr Leu Met 
            100                 105                 110         


Ser Ala Glu Ala Asn Leu Ala Gly Leu Phe Pro Pro Asn Gly Met Gln 
        115                 120                 125             


Arg Phe Asn Pro Asn Ile Ser Trp Gln Pro Ile Pro Val His Thr Val 
    130                 135                 140                 


Pro Ile Thr Glu Asp Arg Gln Ala Gln Val Thr Arg Thr Val Glu His 
145                 150                 155                 160 


Ser Ala 
        


<210>  139
<211>  305
<212>  PRT
<213>  Homo Sapiens

<400>  139

Met Ala Gly Lys Arg Ser Gly Trp Ser Arg Ala Ala Leu Leu Gln Leu 
1               5                   10                  15      


Leu Leu Gly Val Asn Leu Val Val Met Pro Pro Thr Arg Ala Arg Ser 
            20                  25                  30          


Leu Arg Phe Val Thr Leu Leu Tyr Arg His Gly Asp Arg Ser Pro Val 
        35                  40                  45              


Lys Thr Tyr Pro Lys Asp Pro Tyr Gln Glu Glu Glu Trp Pro Gln Gly 
    50                  55                  60                  


Phe Gly Gln Leu Thr Lys Glu Gly Met Leu Gln His Trp Glu Leu Gly 
65                  70                  75                  80  


Gln Ala Leu Arg Gln Arg Tyr His Gly Phe Leu Asn Thr Ser Tyr His 
                85                  90                  95      


Arg Gln Glu Val Tyr Val Arg Ser Thr Asp Phe Asp Arg Thr Leu Met 
            100                 105                 110         


Ser Ala Glu Ala Asn Leu Ala Gly Leu Phe Pro Pro Asn Gly Met Gln 
        115                 120                 125             


Arg Phe Asn Pro Asn Ile Ser Trp Gln Pro Ile Pro Val His Thr Val 
    130                 135                 140                 


Pro Ile Thr Glu Asp Arg Gln Phe Leu Asp Met Val Ala Asn Glu Thr 
145                 150                 155                 160 


Gly Leu Thr Asp Leu Thr Leu Glu Thr Val Trp Asn Val Tyr Asp Thr 
                165                 170                 175     


Leu Phe Cys Glu Gln Thr His Gly Leu Arg Leu Pro Pro Trp Ala Ser 
            180                 185                 190         


Pro Gln Thr Met Gln Arg Leu Ser Arg Leu Lys Asp Phe Ser Phe Arg 
        195                 200                 205             


Phe Leu Phe Gly Ile Tyr Gln Gln Ala Glu Lys Ala Arg Leu Gln Gly 
    210                 215                 220                 


Gly Val Leu Leu Ala Gln Ile Arg Lys Asn Leu Thr Leu Met Ala Thr 
225                 230                 235                 240 


Thr Ser Gln Leu Pro Lys Leu Leu Val Tyr Ser Ala His Asp Thr Thr 
                245                 250                 255     


Leu Val Ala Leu Gln Met Ala Leu Asp Val Tyr Asn Gly Glu Gln Ala 
            260                 265                 270         


Pro Tyr Ala Ser Cys His Ile Phe Glu Leu Tyr Gln Glu Asp Ser Gly 
        275                 280                 285             


Asn Phe Ser Val Glu Met Tyr Phe Arg Asn Glu Ser Asp Lys Ala Pro 
    290                 295                 300                 


Trp 
305 


<210>  140
<211>  360
<212>  PRT
<213>  Homo Sapiens

<400>  140

Met Ala Gly Lys Arg Ser Gly Trp Ser Arg Ala Ala Leu Leu Gln Leu 
1               5                   10                  15      


Leu Leu Gly Val Asn Leu Val Val Met Pro Pro Thr Arg Ala Arg Ser 
            20                  25                  30          


Leu Arg Phe Val Thr Leu Leu Tyr Arg His Gly Asp Arg Ser Pro Val 
        35                  40                  45              


Lys Thr Tyr Pro Lys Asp Pro Tyr Gln Glu Glu Glu Trp Pro Gln Gly 
    50                  55                  60                  


Phe Gly Gln Leu Thr Lys Glu Gly Met Leu Gln His Trp Glu Leu Gly 
65                  70                  75                  80  


Gln Ala Leu Arg Gln Arg Tyr His Gly Phe Leu Asn Thr Ser Tyr His 
                85                  90                  95      


Arg Gln Glu Val Tyr Val Arg Ser Thr Asp Phe Asp Arg Thr Leu Met 
            100                 105                 110         


Ser Ala Glu Ala Asn Leu Ala Gly Leu Phe Pro Pro Asn Gly Met Gln 
        115                 120                 125             


Arg Phe Asn Pro Asn Ile Ser Trp Gln Pro Ile Pro Val His Thr Val 
    130                 135                 140                 


Pro Ile Thr Glu Asp Arg Gln Thr His Gly Leu Arg Leu Pro Pro Trp 
145                 150                 155                 160 


Ala Ser Pro Gln Thr Met Gln Arg Leu Ser Arg Leu Lys Asp Phe Ser 
                165                 170                 175     


Phe Arg Phe Leu Phe Gly Ile Tyr Gln Gln Ala Glu Lys Ala Arg Leu 
            180                 185                 190         


Gln Gly Gly Val Leu Leu Ala Gln Ile Arg Lys Asn Leu Thr Leu Met 
        195                 200                 205             


Ala Thr Thr Ser Gln Leu Pro Lys Leu Leu Val Tyr Ser Ala His Asp 
    210                 215                 220                 


Thr Thr Leu Val Ala Leu Gln Met Ala Leu Asp Val Tyr Asn Gly Glu 
225                 230                 235                 240 


Gln Ala Pro Tyr Ala Ser Cys His Ile Phe Glu Leu Tyr Gln Glu Asp 
                245                 250                 255     


Ser Gly Asn Phe Ser Val Glu Met Tyr Phe Arg Asn Glu Ser Asp Lys 
            260                 265                 270         


Ala Pro Trp Pro Leu Ser Leu Pro Gly Cys Pro His Arg Cys Pro Leu 
        275                 280                 285             


Gln Asp Phe Leu Arg Leu Thr Glu Pro Val Val Pro Lys Asp Trp Gln 
    290                 295                 300                 


Gln Glu Cys Gln Leu Ala Ser Gly Pro Ala Asp Thr Glu Val Ile Val 
305                 310                 315                 320 


Ala Leu Ala Val Cys Gly Ser Ile Leu Phe Leu Leu Ile Val Leu Leu 
                325                 330                 335     


Leu Thr Val Leu Phe Arg Met Gln Ala Gln Pro Pro Gly Tyr Arg His 
            340                 345                 350         


Val Ala Asp Gly Glu Asp His Ala 
        355                 360 


<210>  141
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  141

Met Ala Gly Lys Arg Ser Gly Trp Ser Arg Ala Ala Leu Leu Gln Leu 
1               5                   10                  15      


Leu Leu Gly Val Asn Leu Val Val Met Pro Pro Thr Arg Ala Arg Ser 
            20                  25                  30          


Leu Arg Phe Val Thr Leu Leu Tyr Arg His Gly Asp Arg Ser Pro Val 
        35                  40                  45              


Lys Thr Tyr Pro Lys Asp Pro Tyr Gln Glu Glu Glu Trp Pro Gln Gly 
    50                  55                  60                  


Phe Gly Gln Leu Thr Lys Glu Gly Met Leu Gln His Trp Glu Leu Gly 
65                  70                  75                  80  


Gln Ala Leu Arg Gln Arg Tyr His Gly Phe Leu Asn Thr Ser Tyr His 
                85                  90                  95      


Arg Gln Glu Val Tyr Val Arg Ser Thr Asp Phe Asp Arg Thr Leu Met 
            100                 105                 110         


Ser Ala Glu Ala Asn Leu Ala Gly Leu Phe Pro Pro Asn Gly Met Gln 
        115                 120                 125             


Arg Phe Asn Pro Asn Ile Ser Trp Gln Pro Ile Pro Val His Thr Val 
    130                 135                 140                 


Pro Ile Thr Glu Asp Arg Ser Arg Thr Glu Thr Leu Ile His Phe Ser 
145                 150                 155                 160 


<210>  142
<211>  395
<212>  PRT
<213>  Homo Sapiens

<400>  142

Met Gly Val Arg Met Thr Glu Tyr Val Gly Leu Tyr Arg His Gly Asp 
1               5                   10                  15      


Arg Ser Pro Val Lys Thr Tyr Pro Lys Asp Pro Tyr Gln Glu Glu Glu 
            20                  25                  30          


Trp Pro Gln Gly Phe Gly Gln Leu Thr Lys Glu Gly Met Leu Gln His 
        35                  40                  45              


Trp Glu Leu Gly Gln Ala Leu Arg Gln Arg Tyr His Gly Phe Leu Asn 
    50                  55                  60                  


Thr Ser Tyr His Arg Gln Glu Val Tyr Val Arg Ser Thr Asp Phe Asp 
65                  70                  75                  80  


Arg Thr Leu Met Ser Ala Glu Ala Asn Leu Ala Gly Leu Phe Pro Pro 
                85                  90                  95      


Asn Gly Met Gln Arg Phe Asn Pro Asn Ile Ser Trp Gln Pro Ile Pro 
            100                 105                 110         


Val His Thr Val Pro Ile Thr Glu Asp Arg Leu Leu Lys Phe Pro Leu 
        115                 120                 125             


Gly Pro Cys Pro Arg Tyr Glu Gln Leu Gln Asn Glu Thr Arg Gln Thr 
    130                 135                 140                 


Pro Glu Tyr Gln Asn Glu Ser Ser Arg Asn Ala Gln Phe Leu Asp Met 
145                 150                 155                 160 


Val Ala Asn Glu Thr Gly Leu Thr Asp Leu Thr Leu Glu Thr Val Trp 
                165                 170                 175     


Asn Val Tyr Asp Thr Leu Phe Cys Glu Gln Thr His Gly Leu Arg Leu 
            180                 185                 190         


Pro Pro Trp Ala Ser Pro Gln Thr Met Gln Arg Leu Ser Arg Leu Lys 
        195                 200                 205             


Asp Phe Ser Phe Arg Phe Leu Phe Gly Ile Tyr Gln Gln Ala Glu Lys 
    210                 215                 220                 


Ala Arg Leu Gln Gly Gly Val Leu Leu Ala Gln Ile Arg Lys Asn Leu 
225                 230                 235                 240 


Thr Leu Met Ala Thr Thr Ser Gln Leu Pro Lys Leu Leu Val Tyr Ser 
                245                 250                 255     


Ala His Asp Thr Thr Leu Val Ala Leu Gln Met Ala Leu Asp Val Tyr 
            260                 265                 270         


Asn Gly Glu Gln Ala Pro Tyr Ala Ser Cys His Ile Phe Glu Leu Tyr 
        275                 280                 285             


Gln Glu Asp Ser Gly Asn Phe Ser Val Glu Met Tyr Phe Arg Asn Glu 
    290                 295                 300                 


Ser Asp Lys Ala Pro Trp Pro Leu Ser Leu Pro Gly Cys Pro His Arg 
305                 310                 315                 320 


Cys Pro Leu Gln Asp Phe Leu Arg Leu Thr Glu Pro Val Val Pro Lys 
                325                 330                 335     


Asp Trp Gln Gln Glu Cys Gln Leu Ala Ser Gly Pro Ala Asp Thr Glu 
            340                 345                 350         


Val Ile Val Ala Leu Ala Val Cys Gly Ser Ile Leu Phe Leu Leu Ile 
        355                 360                 365             


Val Leu Leu Leu Thr Val Leu Phe Arg Met Gln Ala Gln Pro Pro Gly 
    370                 375                 380                 


Tyr Arg His Val Ala Asp Gly Glu Asp His Ala 
385                 390                 395 


<210>  143
<211>  6
<212>  PRT
<213>  Homo Sapiens

<400>  143

Met Asp Met Trp Thr Ala 
1               5       


<210>  144
<211>  52
<212>  PRT
<213>  Homo Sapiens

<400>  144

Met Asp Met Trp Thr Ala Leu Leu Ile Leu Gln Ala Leu Leu Leu Pro 
1               5                   10                  15      


Ser Leu Ala Asp Gly Ala Thr Pro Ala Leu Arg Phe Val Ala Val Gly 
            20                  25                  30          


Asp Trp Gly Gly Val Pro Asn Ala Pro Phe His Thr Ala Arg Glu Met 
        35                  40                  45              


Ala Asn Ala Lys 
    50          


<210>  145
<211>  74
<212>  PRT
<213>  Homo Sapiens

<400>  145

Met Asp Met Trp Thr Ala Leu Leu Ile Leu Gln Ala Leu Leu Leu Pro 
1               5                   10                  15      


Ser Leu Ala Asp Gly Ala Thr Pro Ala Leu Arg Phe Val Ala Val Gly 
            20                  25                  30          


Asp Trp Gly Gly Val Pro Asn Ala Pro Phe His Thr Ala Arg Glu Met 
        35                  40                  45              


Ala Asn Ala Lys Glu Ile Ala Arg Thr Val Gln Ile Leu Gly Ala Asp 
    50                  55                  60                  


Phe Ile Leu Ser Leu Gly Asp Asn Phe Tyr 
65                  70                  


<210>  146
<211>  124
<212>  PRT
<213>  Homo Sapiens

<400>  146

Met Asp Met Trp Thr Ala Leu Leu Ile Leu Gln Ala Leu Leu Leu Pro 
1               5                   10                  15      


Ser Leu Ala Asp Gly Ala Thr Pro Ala Leu Arg Phe Val Ala Val Gly 
            20                  25                  30          


Asp Trp Gly Gly Val Pro Asn Ala Pro Phe His Thr Ala Arg Glu Met 
        35                  40                  45              


Ala Asn Ala Lys Glu Ile Ala Arg Thr Val Gln Ile Leu Gly Ala Asp 
    50                  55                  60                  


Phe Ile Leu Ser Leu Gly Asp Asn Phe Tyr Phe Thr Gly Val Gln Asp 
65                  70                  75                  80  


Ile Asn Asp Lys Arg Phe Gln Glu Thr Phe Glu Asp Val Phe Ser Asp 
                85                  90                  95      


Arg Ser Leu Arg Lys Val Pro Trp Tyr Val Leu Ala Gly Asn His Asp 
            100                 105                 110         


His Leu Gly Asn Val Ser Ala Gln Ile Ala Tyr Ser 
        115                 120                 


<210>  147
<211>  325
<212>  PRT
<213>  Homo Sapiens

<400>  147

Met Asp Met Trp Thr Ala Leu Leu Ile Leu Gln Ala Leu Leu Leu Pro 
1               5                   10                  15      


Ser Leu Ala Asp Gly Ala Thr Pro Ala Leu Arg Phe Val Ala Val Gly 
            20                  25                  30          


Asp Trp Gly Gly Val Pro Asn Ala Pro Phe His Thr Ala Arg Glu Met 
        35                  40                  45              


Ala Asn Ala Lys Glu Ile Ala Arg Thr Val Gln Ile Leu Gly Ala Asp 
    50                  55                  60                  


Phe Ile Leu Ser Leu Gly Asp Asn Phe Tyr Phe Thr Gly Val Gln Asp 
65                  70                  75                  80  


Ile Asn Asp Lys Arg Phe Gln Glu Thr Phe Glu Asp Val Phe Ser Asp 
                85                  90                  95      


Arg Ser Leu Arg Lys Val Pro Trp Tyr Val Leu Ala Gly Asn His Asp 
            100                 105                 110         


His Leu Gly Asn Val Ser Ala Gln Ile Ala Tyr Ser Lys Ile Ser Lys 
        115                 120                 125             


Arg Trp Asn Phe Pro Ser Pro Phe Tyr Arg Leu His Phe Lys Ile Pro 
    130                 135                 140                 


Gln Thr Asn Val Ser Val Ala Ile Phe Met Leu Asp Thr Val Thr Leu 
145                 150                 155                 160 


Cys Gly Asn Ser Asp Asp Phe Leu Ser Gln Gln Pro Glu Arg Pro Arg 
                165                 170                 175     


Asp Val Lys Leu Ala Arg Thr Gln Leu Ser Trp Leu Lys Lys Gln Leu 
            180                 185                 190         


Ala Ala Ala Arg Glu Asp Tyr Val Leu Val Ala Gly His Tyr Pro Val 
        195                 200                 205             


Trp Ser Ile Ala Glu His Gly Pro Thr His Cys Leu Val Lys Gln Leu 
    210                 215                 220                 


Arg Pro Leu Leu Ala Thr Tyr Gly Val Thr Ala Tyr Leu Cys Gly His 
225                 230                 235                 240 


Asp His Asn Leu Gln Tyr Leu Gln Asp Glu Asn Gly Val Gly Tyr Val 
                245                 250                 255     


Leu Ser Gly Ala Gly Asn Phe Met Asp Pro Ser Lys Arg His Gln Arg 
            260                 265                 270         


Lys Val Pro Asn Gly Tyr Leu Arg Phe His Tyr Gly Thr Glu Asp Ser 
        275                 280                 285             


Leu Gly Gly Phe Ala Tyr Val Glu Ile Ser Ser Lys Glu Met Thr Val 
    290                 295                 300                 


Thr Tyr Ile Glu Ala Ser Gly Lys Ser Leu Phe Lys Thr Arg Leu Pro 
305                 310                 315                 320 


Arg Arg Ala Arg Pro 
                325 


<210>  148
<211>  325
<212>  PRT
<213>  Homo Sapiens

<400>  148

Met Asp Met Trp Thr Ala Leu Leu Ile Leu Gln Ala Leu Leu Leu Pro 
1               5                   10                  15      


Ser Leu Ala Asp Gly Ala Thr Pro Ala Leu Arg Phe Val Ala Val Gly 
            20                  25                  30          


Asp Trp Gly Gly Val Pro Asn Ala Pro Phe His Thr Ala Arg Glu Met 
        35                  40                  45              


Ala Asn Ala Lys Glu Ile Ala Arg Thr Val Gln Ile Leu Gly Ala Asp 
    50                  55                  60                  


Phe Ile Leu Ser Leu Gly Asp Asn Phe Tyr Phe Thr Gly Val Gln Asp 
65                  70                  75                  80  


Ile Asn Asp Lys Arg Phe Gln Glu Thr Phe Glu Asp Val Phe Ser Asp 
                85                  90                  95      


Arg Ser Leu Arg Lys Val Pro Trp Tyr Val Leu Ala Gly Asn His Asp 
            100                 105                 110         


His Leu Gly Asn Val Ser Ala Gln Ile Ala Tyr Ser Lys Ile Ser Lys 
        115                 120                 125             


Arg Trp Asn Phe Pro Ser Pro Phe Tyr Arg Leu His Phe Lys Ile Pro 
    130                 135                 140                 


Gln Thr Asn Val Ser Val Ala Ile Phe Met Leu Asp Thr Val Thr Leu 
145                 150                 155                 160 


Cys Gly Asn Ser Asp Asp Phe Leu Ser Gln Gln Pro Glu Arg Pro Arg 
                165                 170                 175     


Asp Val Lys Leu Ala Arg Thr Gln Leu Ser Trp Leu Lys Lys Gln Leu 
            180                 185                 190         


Ala Ala Ala Arg Glu Asp Tyr Val Leu Val Ala Gly His Tyr Pro Val 
        195                 200                 205             


Trp Ser Ile Ala Glu His Gly Pro Thr His Cys Leu Val Lys Gln Leu 
    210                 215                 220                 


Arg Pro Leu Leu Ala Thr Tyr Gly Val Thr Ala Tyr Leu Cys Gly His 
225                 230                 235                 240 


Asp His Asn Leu Gln Tyr Leu Gln Asp Glu Asn Gly Val Gly Tyr Val 
                245                 250                 255     


Leu Ser Gly Ala Gly Asn Phe Met Asp Pro Ser Lys Arg His Gln Arg 
            260                 265                 270         


Lys Val Pro Asn Gly Tyr Leu Arg Phe His Tyr Gly Thr Glu Asp Ser 
        275                 280                 285             


Leu Gly Gly Phe Ala Tyr Val Glu Ile Ser Ser Lys Glu Met Thr Val 
    290                 295                 300                 


Thr Tyr Ile Glu Ala Ser Gly Lys Ser Leu Phe Lys Thr Arg Leu Pro 
305                 310                 315                 320 


Arg Arg Ala Arg Pro 
                325 


<210>  149
<211>  325
<212>  PRT
<213>  Homo Sapiens

<400>  149

Met Asp Met Trp Thr Ala Leu Leu Ile Leu Gln Ala Leu Leu Leu Pro 
1               5                   10                  15      


Ser Leu Ala Asp Gly Ala Thr Pro Ala Leu Arg Phe Val Ala Val Gly 
            20                  25                  30          


Asp Trp Gly Gly Val Pro Asn Ala Pro Phe His Thr Ala Arg Glu Met 
        35                  40                  45              


Ala Asn Ala Lys Glu Ile Ala Arg Thr Val Gln Ile Leu Gly Ala Asp 
    50                  55                  60                  


Phe Ile Leu Ser Leu Gly Asp Asn Phe Tyr Phe Thr Gly Val Gln Asp 
65                  70                  75                  80  


Ile Asn Asp Lys Arg Phe Gln Glu Thr Phe Glu Asp Val Phe Ser Asp 
                85                  90                  95      


Arg Ser Leu Arg Lys Val Pro Trp Tyr Val Leu Ala Gly Asn His Asp 
            100                 105                 110         


His Leu Gly Asn Val Ser Ala Gln Ile Ala Tyr Ser Lys Ile Ser Lys 
        115                 120                 125             


Arg Trp Asn Phe Pro Ser Pro Phe Tyr Arg Leu His Phe Lys Ile Pro 
    130                 135                 140                 


Gln Thr Asn Val Ser Val Ala Ile Phe Met Leu Asp Thr Val Thr Leu 
145                 150                 155                 160 


Cys Gly Asn Ser Asp Asp Phe Leu Ser Gln Gln Pro Glu Arg Pro Arg 
                165                 170                 175     


Asp Val Lys Leu Ala Arg Thr Gln Leu Ser Trp Leu Lys Lys Gln Leu 
            180                 185                 190         


Ala Ala Ala Arg Glu Asp Tyr Val Leu Val Ala Gly His Tyr Pro Val 
        195                 200                 205             


Trp Ser Ile Ala Glu His Gly Pro Thr His Cys Leu Val Lys Gln Leu 
    210                 215                 220                 


Arg Pro Leu Leu Ala Thr Tyr Gly Val Thr Ala Tyr Leu Cys Gly His 
225                 230                 235                 240 


Asp His Asn Leu Gln Tyr Leu Gln Asp Glu Asn Gly Val Gly Tyr Val 
                245                 250                 255     


Leu Ser Gly Ala Gly Asn Phe Met Asp Pro Ser Lys Arg His Gln Arg 
            260                 265                 270         


Lys Val Pro Asn Gly Tyr Leu Arg Phe His Tyr Gly Thr Glu Asp Ser 
        275                 280                 285             


Leu Gly Gly Phe Ala Tyr Val Glu Ile Ser Ser Lys Glu Met Thr Val 
    290                 295                 300                 


Thr Tyr Ile Glu Ala Ser Gly Lys Ser Leu Phe Lys Thr Arg Leu Pro 
305                 310                 315                 320 


Arg Arg Ala Arg Pro 
                325 


<210>  150
<211>  325
<212>  PRT
<213>  Homo Sapiens

<400>  150

Met Asp Met Trp Thr Ala Leu Leu Ile Leu Gln Ala Leu Leu Leu Pro 
1               5                   10                  15      


Ser Leu Ala Asp Gly Ala Thr Pro Ala Leu Arg Phe Val Ala Val Gly 
            20                  25                  30          


Asp Trp Gly Gly Val Pro Asn Ala Pro Phe His Thr Ala Arg Glu Met 
        35                  40                  45              


Ala Asn Ala Lys Glu Ile Ala Arg Thr Val Gln Ile Leu Gly Ala Asp 
    50                  55                  60                  


Phe Ile Leu Ser Leu Gly Asp Asn Phe Tyr Phe Thr Gly Val Gln Asp 
65                  70                  75                  80  


Ile Asn Asp Lys Arg Phe Gln Glu Thr Phe Glu Asp Val Phe Ser Asp 
                85                  90                  95      


Arg Ser Leu Arg Lys Val Pro Trp Tyr Val Leu Ala Gly Asn His Asp 
            100                 105                 110         


His Leu Gly Asn Val Ser Ala Gln Ile Ala Tyr Ser Lys Ile Ser Lys 
        115                 120                 125             


Arg Trp Asn Phe Pro Ser Pro Phe Tyr Arg Leu His Phe Lys Ile Pro 
    130                 135                 140                 


Gln Thr Asn Val Ser Val Ala Ile Phe Met Leu Asp Thr Val Thr Leu 
145                 150                 155                 160 


Cys Gly Asn Ser Asp Asp Phe Leu Ser Gln Gln Pro Glu Arg Pro Arg 
                165                 170                 175     


Asp Val Lys Leu Ala Arg Thr Gln Leu Ser Trp Leu Lys Lys Gln Leu 
            180                 185                 190         


Ala Ala Ala Arg Glu Asp Tyr Val Leu Val Ala Gly His Tyr Pro Val 
        195                 200                 205             


Trp Ser Ile Ala Glu His Gly Pro Thr His Cys Leu Val Lys Gln Leu 
    210                 215                 220                 


Arg Pro Leu Leu Ala Thr Tyr Gly Val Thr Ala Tyr Leu Cys Gly His 
225                 230                 235                 240 


Asp His Asn Leu Gln Tyr Leu Gln Asp Glu Asn Gly Val Gly Tyr Val 
                245                 250                 255     


Leu Ser Gly Ala Gly Asn Phe Met Asp Pro Ser Lys Arg His Gln Arg 
            260                 265                 270         


Lys Val Pro Asn Gly Tyr Leu Arg Phe His Tyr Gly Thr Glu Asp Ser 
        275                 280                 285             


Leu Gly Gly Phe Ala Tyr Val Glu Ile Ser Ser Lys Glu Met Thr Val 
    290                 295                 300                 


Thr Tyr Ile Glu Ala Ser Gly Lys Ser Leu Phe Lys Thr Arg Leu Pro 
305                 310                 315                 320 


Arg Arg Ala Arg Pro 
                325 


<210>  151
<211>  59
<212>  PRT
<213>  Homo Sapiens

<400>  151

Met Asp Met Trp Thr Ala Leu Leu Ile Leu Gln Ala Leu Leu Leu Pro 
1               5                   10                  15      


Ser Leu Gly Ile Ser Trp Thr Pro Gln Ser Gly Thr Ser Ala Arg Ser 
            20                  25                  30          


Pro Thr Ala Ile Cys Ala Ser Thr Met Gly Leu Lys Thr His Trp Val 
        35                  40                  45              


Ala Leu Pro Met Trp Arg Ser Ala Pro Lys Arg 
    50                  55                  


<210>  152
<211>  228
<212>  PRT
<213>  Homo Sapiens

<400>  152

Met Ile Thr Gly Val Phe Ser Met Arg Leu Trp Thr Pro Val Gly Val 
1               5                   10                  15      


Leu Thr Ser Leu Ala Tyr Cys Leu His Gln Arg Arg Val Ala Leu Ala 
            20                  25                  30          


Glu Leu Gln Glu Ala Asp Gly Gln Cys Pro Val Asp Arg Ser Leu Leu 
        35                  40                  45              


Lys Leu Lys Met Val Gln Val Val Phe Arg His Gly Ala Arg Ser Pro 
    50                  55                  60                  


Leu Lys Pro Leu Pro Leu Glu Glu Gln Gly Gly Met Phe Ala Gly Gln 
65                  70                  75                  80  


Leu Thr Lys Val Gly Met Gln Gln Met Phe Ala Leu Gly Glu Arg Leu 
                85                  90                  95      


Arg Lys Asn Tyr Val Glu Asp Ile Pro Phe Leu Ser Pro Thr Phe Asn 
            100                 105                 110         


Pro Gln Glu Val Phe Ile Arg Ser Thr Asn Ile Phe Arg Asn Leu Glu 
        115                 120                 125             


Ser Thr Arg Cys Leu Leu Ala Gly Leu Phe Gln Cys Gln Lys Glu Gly 
    130                 135                 140                 


Pro Ile Ile Ile His Thr Asp Glu Ala Asp Ser Glu Val Leu Tyr Pro 
145                 150                 155                 160 


Asn Tyr Gln Ser Cys Trp Ser Leu Arg Gln Arg Thr Arg Gly Arg Arg 
                165                 170                 175     


Gln Thr Ala Ser Leu Gln Pro Gly Ile Ser Glu Asp Leu Lys Lys Val 
            180                 185                 190         


Lys Asp Arg Met Gly Ile Asp Ser Ser Asp Lys Val Asp Phe Phe Ile 
        195                 200                 205             


Leu Leu Asp Asn Val Ala Ala Glu Gln Glu Lys Met Gly Ser Cys Arg 
    210                 215                 220                 


Phe His Gly Ser 
225             


<210>  153
<211>  428
<212>  PRT
<213>  Homo Sapiens

<400>  153

Met Ile Thr Gly Val Phe Ser Met Arg Leu Trp Thr Pro Val Gly Val 
1               5                   10                  15      


Leu Thr Ser Leu Ala Tyr Cys Leu His Gln Arg Arg Val Ala Leu Ala 
            20                  25                  30          


Glu Leu Gln Glu Ala Asp Gly Gln Cys Pro Val Asp Arg Ser Leu Leu 
        35                  40                  45              


Lys Leu Lys Met Val Gln Val Val Phe Arg His Gly Ala Arg Ser Pro 
    50                  55                  60                  


Leu Lys Pro Leu Pro Leu Glu Glu Gln Val Glu Trp Asn Pro Gln Leu 
65                  70                  75                  80  


Leu Glu Val Pro Pro Gln Thr Gln Phe Asp Tyr Thr Val Thr Asn Leu 
                85                  90                  95      


Ala Gly Gly Pro Lys Pro Tyr Ser Pro Tyr Asp Ser Gln Tyr His Glu 
            100                 105                 110         


Thr Thr Leu Lys Gly Gly Met Phe Ala Gly Gln Leu Thr Lys Val Gly 
        115                 120                 125             


Met Gln Gln Met Phe Ala Leu Gly Glu Arg Leu Arg Lys Asn Tyr Val 
    130                 135                 140                 


Glu Asp Ile Pro Phe Leu Ser Pro Thr Phe Asn Pro Gln Glu Val Phe 
145                 150                 155                 160 


Ile Arg Ser Thr Asn Ile Phe Arg Asn Leu Glu Ser Thr Arg Cys Leu 
                165                 170                 175     


Leu Ala Gly Leu Phe Gln Cys Gln Lys Glu Gly Pro Ile Ile Ile His 
            180                 185                 190         


Thr Asp Glu Ala Asp Ser Glu Val Leu Tyr Pro Asn Tyr Gln Ser Cys 
        195                 200                 205             


Trp Ser Leu Arg Gln Arg Thr Arg Gly Arg Arg Gln Thr Ala Ser Leu 
    210                 215                 220                 


Gln Pro Gly Ile Ser Glu Asp Leu Lys Lys Val Lys Asp Arg Met Gly 
225                 230                 235                 240 


Ile Asp Ser Ser Asp Lys Val Asp Phe Phe Ile Leu Leu Asp Asn Val 
                245                 250                 255     


Ala Ala Glu Gln Ala His Asn Leu Pro Ser Cys Pro Met Leu Lys Arg 
            260                 265                 270         


Phe Ala Arg Met Ile Glu Gln Arg Ala Val Asp Thr Ser Leu Tyr Ile 
        275                 280                 285             


Leu Pro Lys Glu Asp Arg Glu Ser Leu Gln Met Ala Val Gly Pro Phe 
    290                 295                 300                 


Leu His Ile Leu Glu Ser Asn Leu Leu Lys Ala Met Asp Ser Ala Thr 
305                 310                 315                 320 


Ala Pro Asp Lys Ile Arg Lys Leu Tyr Leu Tyr Ala Ala His Asp Val 
                325                 330                 335     


Thr Phe Ile Pro Leu Leu Met Thr Leu Gly Ile Phe Asp His Lys Trp 
            340                 345                 350         


Pro Pro Phe Ala Val Asp Leu Thr Met Glu Leu Tyr Gln His Leu Glu 
        355                 360                 365             


Ser Lys Glu Trp Phe Val Gln Leu Tyr Tyr His Gly Lys Glu Gln Val 
    370                 375                 380                 


Pro Arg Gly Cys Pro Asp Gly Leu Cys Pro Leu Asp Met Phe Leu Asn 
385                 390                 395                 400 


Ala Met Ser Val Tyr Thr Leu Ser Pro Glu Lys Tyr His Ala Leu Cys 
                405                 410                 415     


Ser Gln Thr Gln Val Met Glu Val Gly Asn Glu Glu 
            420                 425             


<210>  154
<211>  271
<212>  PRT
<213>  Homo Sapiens

<400>  154

Met Ile Thr Gly Val Phe Ser Met Arg Leu Trp Thr Pro Val Gly Val 
1               5                   10                  15      


Leu Thr Ser Leu Ala Tyr Cys Leu His Gln Arg Arg Val Ala Leu Ala 
            20                  25                  30          


Glu Leu Gln Glu Ala Asp Gly Gln Cys Pro Val Asp Arg Ser Leu Leu 
        35                  40                  45              


Lys Leu Lys Met Val Gln Val Val Phe Arg His Gly Ala Arg Ser Pro 
    50                  55                  60                  


Leu Lys Pro Leu Pro Leu Glu Glu Gln Val Glu Trp Asn Pro Gln Leu 
65                  70                  75                  80  


Leu Glu Val Pro Pro Gln Thr Gln Phe Asp Tyr Thr Val Thr Asn Leu 
                85                  90                  95      


Ala Gly Gly Pro Lys Pro Tyr Ser Pro Tyr Asp Ser Gln Tyr His Glu 
            100                 105                 110         


Thr Thr Leu Lys Gly Gly Met Phe Ala Gly Gln Leu Thr Lys Val Gly 
        115                 120                 125             


Met Gln Gln Met Phe Ala Leu Gly Glu Arg Leu Arg Lys Asn Tyr Val 
    130                 135                 140                 


Glu Asp Ile Pro Phe Leu Ser Pro Thr Phe Asn Pro Gln Glu Val Phe 
145                 150                 155                 160 


Ile Arg Ser Thr Asn Ile Phe Arg Asn Leu Glu Ser Thr Arg Cys Leu 
                165                 170                 175     


Leu Ala Gly Leu Phe Gln Cys Gln Lys Glu Gly Pro Ile Ile Ile His 
            180                 185                 190         


Thr Asp Glu Ala Asp Ser Glu Val Leu Tyr Pro Asn Tyr Gln Ser Cys 
        195                 200                 205             


Trp Ser Leu Arg Gln Arg Thr Arg Gly Arg Arg Gln Thr Ala Ser Leu 
    210                 215                 220                 


Gln Pro Gly Ile Ser Glu Asp Leu Lys Lys Val Lys Asp Arg Met Gly 
225                 230                 235                 240 


Ile Asp Ser Ser Asp Lys Val Asp Phe Phe Ile Leu Leu Asp Asn Val 
                245                 250                 255     


Ala Ala Glu Gln Glu Lys Met Gly Ser Cys Arg Phe His Gly Ser 
            260                 265                 270     


<210>  155
<211>  77
<212>  PRT
<213>  Homo Sapiens

<400>  155

Met Ile Thr Gly Val Phe Ser Met Arg Leu Trp Thr Pro Val Gly Val 
1               5                   10                  15      


Leu Thr Ser Leu Ala Tyr Cys Leu His Gln Arg Arg Val Ala Leu Ala 
            20                  25                  30          


Glu Leu Gln Glu Ala Asp Gly Gln Cys Pro Val Asp Arg Ser Leu Leu 
        35                  40                  45              


Lys Leu Lys Met Val Gln Val Val Phe Arg His Gly Ala Arg Ser Pro 
    50                  55                  60                  


Leu Lys Pro Leu Pro Leu Glu Glu Gln Tyr Ser Phe His 
65                  70                  75          


<210>  156
<211>  143
<212>  PRT
<213>  Homo Sapiens

<400>  156

Met Val Gln Val Val Phe Arg His Gly Ala Arg Ser Pro Leu Lys Pro 
1               5                   10                  15      


Leu Pro Leu Glu Glu Gln Val Glu Trp Asn Pro Gln Leu Leu Glu Val 
            20                  25                  30          


Pro Pro Gln Thr Gln Phe Asp Tyr Thr Val Thr Asn Leu Ala Gly Gly 
        35                  40                  45              


Pro Lys Pro Tyr Ser Pro Tyr Asp Ser Gln Tyr His Glu Thr Thr Leu 
    50                  55                  60                  


Lys Gly Gly Met Phe Ala Gly Gln Leu Thr Lys Val Gly Met Gln Gln 
65                  70                  75                  80  


Met Phe Ala Leu Gly Glu Arg Leu Arg Lys Asn Tyr Val Glu Asp Ile 
                85                  90                  95      


Pro Phe Leu Ser Pro Thr Phe Asn Pro Gln Glu Val Phe Ile Arg Ser 
            100                 105                 110         


Thr Asn Ile Phe Arg Asn Leu Glu Ser Thr Arg Cys Leu Leu Ala Gly 
        115                 120                 125             


Leu Phe Gln Cys Gln Lys Glu Gly Pro Ile Ile Ile His Thr Asp 
    130                 135                 140             


<210>  157
<211>  166
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  157

Xaa Asp Ser Gln Tyr His Glu Thr Thr Leu Lys Gly Gly Met Phe Ala 
1               5                   10                  15      


Gly Gln Leu Thr Lys Val Gly Met Gln Gln Met Phe Ala Leu Gly Glu 
            20                  25                  30          


Arg Leu Arg Lys Asn Tyr Val Glu Asp Ile Pro Phe Leu Ser Pro Thr 
        35                  40                  45              


Phe Asn Pro Gln Glu Val Phe Ile Arg Ser Thr Asn Ile Phe Arg Asn 
    50                  55                  60                  


Leu Glu Ser Thr Arg Cys Leu Leu Ala Gly Leu Phe Gln Cys Gln Lys 
65                  70                  75                  80  


Glu Gly Pro Ile Ile Ile His Thr Asp Glu Ala Asp Ser Glu Val Leu 
                85                  90                  95      


Tyr Pro Asn Tyr Gln Ser Cys Trp Ser Leu Arg Gln Arg Thr Arg Gly 
            100                 105                 110         


Arg Arg Gln Thr Ala Ser Leu Gln Pro Gly Ile Ser Glu Asp Leu Lys 
        115                 120                 125             


Lys Val Lys Asp Arg Met Gly Ile Asp Ser Ser Asp Lys Val Asp Phe 
    130                 135                 140                 


Phe Ile Leu Leu Asp Asn Val Ala Ala Glu Gln Glu Lys Met Gly Ser 
145                 150                 155                 160 


Cys Arg Phe His Gly Ser 
                165     


<210>  158
<211>  157
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  158

Xaa Arg Cys Leu Leu Ala Gly Leu Phe Gln Cys Gln Lys Glu Gly Pro 
1               5                   10                  15      


Ile Ile Ile His Thr Asp Glu Ala Asp Ser Glu Val Leu Tyr Pro Asn 
            20                  25                  30          


Tyr Gln Ser Cys Trp Ser Leu Arg Gln Arg Thr Arg Gly Arg Arg Gln 
        35                  40                  45              


Thr Ala Ser Leu Gln Pro Gly Ile Ser Glu Asp Leu Lys Lys Val Lys 
    50                  55                  60                  


Asp Arg Met Gly Ile Asp Ser Ser Asp Lys Val Asp Phe Phe Ile Leu 
65                  70                  75                  80  


Leu Asp Asn Val Ala Ala Glu Gln Ala His Asn Leu Pro Ser Cys Pro 
                85                  90                  95      


Met Leu Lys Arg Phe Ala Arg Met Ile Glu Gln Arg Ala Val Asp Thr 
            100                 105                 110         


Ser Leu Tyr Ile Leu Pro Lys Glu Asp Arg Glu Ser Leu Gln Met Ala 
        115                 120                 125             


Val Gly Pro Phe Leu His Ile Leu Glu Ser Asn Leu Leu Lys Ala Met 
    130                 135                 140                 


Asp Ser Ala Thr Ala Pro Asp Lys Ile Arg Thr Cys Arg 
145                 150                 155         


<210>  159
<211>  334
<212>  PRT
<213>  Homo Sapiens

<400>  159

Met His Pro Leu Pro Gly Tyr Trp Ser Cys Tyr Cys Leu Leu Leu Leu 
1               5                   10                  15      


Phe Ser Leu Gly Val Gln Gly Ser Leu Gly Ala Pro Ser Ala Ala Pro 
            20                  25                  30          


Glu Gln Val His Leu Ser Tyr Pro Gly Glu Pro Gly Ser Met Thr Val 
        35                  40                  45              


Thr Trp Thr Thr Trp Val Pro Thr Arg Ser Glu Val Gln Phe Gly Leu 
    50                  55                  60                  


Gln Pro Ser Gly Pro Leu Pro Leu Arg Ala Gln Gly Thr Phe Val Pro 
65                  70                  75                  80  


Phe Val Asp Gly Gly Ile Leu Arg Arg Lys Leu Tyr Ile His Arg Val 
                85                  90                  95      


Thr Leu Arg Lys Leu Leu Pro Gly Val Gln Tyr Val Tyr Arg Cys Gly 
            100                 105                 110         


Ser Ala Gln Gly Trp Ser Arg Arg Phe Arg Phe Arg Ala Leu Lys Asn 
        115                 120                 125             


Gly Ala His Trp Ser Pro Arg Leu Ala Val Phe Gly Asp Leu Gly Ala 
    130                 135                 140                 


Asp Asn Pro Lys Ala Val Pro Arg Leu Arg Arg Asp Thr Gln Gln Gly 
145                 150                 155                 160 


Met Tyr Asp Ala Val Leu His Val Ala Thr Ser Leu Thr Thr Arg Leu 
                165                 170                 175     


Ala Ser Ala Cys Arg Gly Ile Met Arg Ala Cys Gly Thr Ala Gly Ile 
            180                 185                 190         


Trp Val Pro Pro Thr Ser Ser Pro Ser Pro Pro Arg Ser Ile Ser Phe 
        195                 200                 205             


Ser Ile Met Ala Ala Thr Trp Tyr Arg Gly Ser Phe Ala Gly Trp Arg 
    210                 215                 220                 


Ala Thr Ser Arg Lys Pro Ile Arg Thr Gly Gln Pro Gly Arg Gly Ser 
225                 230                 235                 240 


Ser Leu Trp Gly Thr Gly Pro Cys Thr Ala Pro Thr Gln Ile Trp Thr 
                245                 250                 255     


Thr Ala His Asp Met Lys Ala Arg Ser Ala Lys Ala Ser Lys Ala Ser 
            260                 265                 270         


Cys Thr Gly Trp Arg Ile Phe Ser Thr Asn Met Glu Trp Ile Cys Ser 
        275                 280                 285             


Cys Gly Leu Met Ser Thr Arg Met Asn Asp Cys Gly Gln Phe Thr Thr 
    290                 295                 300                 


Thr Arg Tyr Leu Thr Ala Ala Glu Arg Cys Pro Thr Pro Thr Arg Glu 
305                 310                 315                 320 


Gly Leu Ser Thr Ser Ser Gln Asp Leu Leu Met Gly Arg Ser 
                325                 330                 


<210>  160
<211>  367
<212>  PRT
<213>  Homo Sapiens

<400>  160

Met His Pro Leu Pro Gly Tyr Trp Ser Cys Tyr Cys Leu Leu Leu Leu 
1               5                   10                  15      


Phe Ser Leu Gly Val Gln Gly Ser Leu Gly Ala Pro Ser Ala Ala Pro 
            20                  25                  30          


Glu Gln Val His Leu Ser Tyr Pro Gly Glu Pro Gly Ser Met Thr Val 
        35                  40                  45              


Thr Trp Thr Thr Trp Val Pro Thr Arg Ser Glu Val Gln Phe Gly Leu 
    50                  55                  60                  


Gln Pro Ser Gly Pro Leu Pro Leu Arg Ala Gln Gly Thr Phe Val Pro 
65                  70                  75                  80  


Phe Val Asp Gly Gly Ile Leu Arg Arg Lys Leu Tyr Ile His Arg Val 
                85                  90                  95      


Thr Leu Arg Lys Leu Leu Pro Gly Val Gln Tyr Val Tyr Arg Cys Gly 
            100                 105                 110         


Ser Ala Gln Gly Trp Ser Arg Arg Phe Arg Phe Arg Ala Leu Lys Asn 
        115                 120                 125             


Gly Ala His Trp Ser Pro Arg Leu Ala Val Phe Gly Asp Leu Gly Ala 
    130                 135                 140                 


Asp Asn Pro Lys Ala Val Pro Arg Leu Arg Arg Asp Thr Gln Gln Gly 
145                 150                 155                 160 


Met Tyr Asp Ala Val Leu His Val Ala Thr Ser Leu Thr Thr Arg Leu 
                165                 170                 175     


Ala Ser Ala Cys Arg Gly Ile Met Arg Ala Cys Gly Thr Gly Asn Val 
            180                 185                 190         


Gly Val Leu Gly Asp Trp Pro Ser Pro Leu Lys Asp Gly Arg Cys Arg 
        195                 200                 205             


Gly Ala Leu Val Pro Asp Pro Cys Pro Leu Thr Pro Pro Ala Gly Ile 
    210                 215                 220                 


Trp Val Pro Pro Thr Ser Ser Pro Ser Pro Pro Arg Ser Ile Ser Phe 
225                 230                 235                 240 


Ser Ile Met Ala Ala Thr Trp Tyr Arg Gly Ser Phe Ala Gly Trp Arg 
                245                 250                 255     


Ala Thr Ser Arg Lys Pro Ile Arg Thr Gly Gln Pro Gly Arg Gly Ser 
            260                 265                 270         


Ser Leu Trp Gly Thr Gly Pro Cys Thr Ala Pro Thr Gln Ile Trp Thr 
        275                 280                 285             


Thr Ala His Asp Met Lys Ala Arg Ser Ala Lys Ala Ser Lys Ala Ser 
    290                 295                 300                 


Cys Thr Gly Trp Arg Ile Phe Ser Thr Asn Met Glu Trp Ile Cys Ser 
305                 310                 315                 320 


Cys Gly Leu Met Ser Thr Arg Met Asn Asp Cys Gly Gln Phe Thr Thr 
                325                 330                 335     


Thr Arg Tyr Leu Thr Ala Ala Glu Arg Cys Pro Thr Pro Thr Arg Glu 
            340                 345                 350         


Gly Leu Ser Thr Ser Ser Gln Asp Leu Leu Ala Val Arg Ser Gly 
        355                 360                 365         


<210>  161
<211>  438
<212>  PRT
<213>  Homo Sapiens

<400>  161

Met His Pro Leu Pro Gly Tyr Trp Ser Cys Tyr Cys Leu Leu Leu Leu 
1               5                   10                  15      


Phe Ser Leu Gly Val Gln Gly Ser Leu Gly Ala Pro Ser Ala Ala Pro 
            20                  25                  30          


Glu Gln Val His Leu Ser Tyr Pro Gly Glu Pro Gly Ser Met Thr Val 
        35                  40                  45              


Thr Trp Thr Thr Trp Val Pro Thr Arg Ser Glu Val Gln Phe Gly Leu 
    50                  55                  60                  


Gln Pro Ser Gly Pro Leu Pro Leu Arg Ala Gln Gly Thr Phe Val Pro 
65                  70                  75                  80  


Phe Val Asp Gly Gly Ile Leu Arg Arg Lys Leu Tyr Ile His Arg Val 
                85                  90                  95      


Thr Leu Arg Lys Leu Leu Pro Gly Val Gln Tyr Val Tyr Arg Cys Gly 
            100                 105                 110         


Ser Ala Gln Gly Trp Ser Arg Arg Phe Arg Phe Arg Ala Leu Lys Asn 
        115                 120                 125             


Gly Ala His Trp Ser Pro Arg Leu Ala Val Phe Gly Asp Leu Gly Ala 
    130                 135                 140                 


Asp Asn Pro Lys Ala Val Pro Arg Leu Arg Arg Asp Thr Gln Gln Gly 
145                 150                 155                 160 


Met Tyr Asp Ala Val Leu His Val Gly Asp Phe Ala Tyr Asn Leu Asp 
                165                 170                 175     


Gln Asp Asn Ala Arg Val Gly Asp Arg Phe Met Arg Leu Ile Glu Pro 
            180                 185                 190         


Val Ala Ala Ser Leu Pro Tyr Met Thr Cys Pro Gly Asn His Glu Glu 
        195                 200                 205             


Arg Tyr Asn Phe Ser Asn Tyr Lys Ala Arg Phe Ser Met Pro Gly Asp 
    210                 215                 220                 


Asn Glu Gly Leu Trp Tyr Ser Trp Asp Leu Gly Pro Ala His Ile Ile 
225                 230                 235                 240 


Ser Phe Ser Thr Glu Val Tyr Phe Phe Leu His Tyr Gly Arg His Leu 
                245                 250                 255     


Val Gln Arg Gln Phe Arg Trp Leu Glu Ser Asp Leu Gln Lys Ala Asn 
            260                 265                 270         


Lys Asn Arg Ala Ala Arg Pro Trp Ile Ile Thr Met Gly His Arg Pro 
        275                 280                 285             


Met Tyr Cys Ser Asn Ala Asp Leu Asp Asp Cys Thr Arg His Glu Ser 
    290                 295                 300                 


Lys Val Arg Lys Gly Leu Gln Gly Lys Leu Tyr Gly Leu Glu Asp Leu 
305                 310                 315                 320 


Phe Tyr Lys Tyr Gly Val Asp Leu Gln Leu Trp Ala His Glu His Ser 
                325                 330                 335     


Tyr Glu Arg Leu Trp Pro Ile Tyr Asn Tyr Gln Val Phe Asn Gly Ser 
            340                 345                 350         


Arg Glu Met Pro Tyr Thr Asn Pro Arg Gly Pro Val His Ile Ile Thr 
        355                 360                 365             


Gly Ser Ala Gly Cys Glu Glu Arg Leu Thr Pro Phe Ala Val Phe Pro 
    370                 375                 380                 


Arg Pro Trp Ser Ala Val Arg Val Lys Glu Tyr Gly Tyr Thr Arg Leu 
385                 390                 395                 400 


His Ile Leu Asn Gly Thr His Ile His Ile Gln Gln Val Ser Asp Asp 
                405                 410                 415     


Gln Asp Gly Lys Ile Val Asp Asp Val Trp Val Val Arg Pro Leu Phe 
            420                 425                 430         


Gly Arg Arg Met Tyr Leu 
        435             


<210>  162
<211>  227
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  162

Xaa Gly Ala Asp Asn Pro Lys Ala Val Pro Arg Leu Arg Arg Asp Thr 
1               5                   10                  15      


Gln Gln Gly Met Tyr Asp Ala Val Leu His Val Gly Asp Phe Ala Tyr 
            20                  25                  30          


Asn Leu Asp Gln Asp Asn Ala Arg Val Gly Asp Arg Phe Met Arg Leu 
        35                  40                  45              


Ile Glu Pro Val Ala Ala Ser Leu Pro Tyr Met Thr Cys Pro Gly Asn 
    50                  55                  60                  


His Glu Glu Arg Tyr Asn Phe Ser Asn Tyr Lys Ala Arg Phe Ser Met 
65                  70                  75                  80  


Pro Gly Asp Asn Glu Gly Leu Trp Tyr Ser Trp Asp Leu Gly Pro Ala 
                85                  90                  95      


His Ile Ile Ser Phe Ser Thr Glu Val Tyr Phe Phe Leu His Tyr Gly 
            100                 105                 110         


Arg His Leu Val Gln Arg Gln Phe Arg Trp Leu Glu Ser Asp Leu Gln 
        115                 120                 125             


Lys Ala Asn Lys Asn Arg Ala Ala Arg Pro Trp Ile Ile Thr Met Gly 
    130                 135                 140                 


His Arg Pro Met Tyr Cys Ser Asn Ala Asp Leu Asp Asp Cys Thr Arg 
145                 150                 155                 160 


His Glu Ser Lys Val Arg Lys Gly Leu Gln Gly Lys Leu Tyr Gly Leu 
                165                 170                 175     


Glu Asp Leu Phe Tyr Lys Tyr Gly Val Asp Leu Gln Leu Trp Ala His 
            180                 185                 190         


Glu His Ser Tyr Glu Arg Leu Trp Pro Ile Tyr Asn Tyr Gln Asp Gly 
        195                 200                 205             


Lys Ile Val Asp Asp Val Trp Val Val Arg Pro Leu Phe Gly Arg Arg 
    210                 215                 220                 


Met Tyr Leu 
225         


<210>  163
<211>  353
<212>  PRT
<213>  Homo Sapiens

<400>  163

Met Arg Ala Ala Pro Leu Leu Leu Ala Arg Ala Ala Ser Leu Ser Leu 
1               5                   10                  15      


Gly Phe Leu Phe Leu Leu Phe Phe Trp Leu Asp Arg Ser Val Leu Ala 
            20                  25                  30          


Lys Glu Leu Lys Phe Val Thr Leu Val Phe Arg His Gly Asp Arg Ser 
        35                  40                  45              


Pro Ile Asp Thr Phe Pro Thr Asp Pro Ile Lys Glu Ser Ser Trp Pro 
    50                  55                  60                  


Gln Gly Phe Gly Gln Leu Thr Gln Leu Gly Met Glu Gln His Tyr Glu 
65                  70                  75                  80  


Leu Gly Glu Tyr Ile Arg Lys Arg Tyr Arg Lys Phe Leu Asn Glu Ser 
                85                  90                  95      


Tyr Lys His Glu Gln Val Tyr Ile Arg Ser Thr Asp Val Asp Arg Thr 
            100                 105                 110         


Leu Met Ser Ala Met Thr Asn Leu Ala Ala Leu Phe Pro Pro Glu Gly 
        115                 120                 125             


Val Ser Ile Trp Asn Pro Ile Leu Leu Trp Gln Pro Ile Pro Val His 
    130                 135                 140                 


Thr Val Pro Leu Ser Glu Asp Gln Asp Phe Ile Ala Thr Leu Gly Lys 
145                 150                 155                 160 


Leu Ser Gly Leu His Gly Gln Asp Leu Phe Gly Ile Trp Ser Lys Val 
                165                 170                 175     


Tyr Asp Pro Leu Tyr Cys Glu Ser Val His Asn Phe Thr Leu Pro Ser 
            180                 185                 190         


Trp Ala Thr Glu Asp Thr Met Thr Lys Leu Arg Glu Leu Ser Glu Leu 
        195                 200                 205             


Ser Leu Leu Ser Leu Tyr Gly Ile His Lys Gln Lys Glu Lys Ser Arg 
    210                 215                 220                 


Leu Gln Gly Gly Val Leu Val Asn Glu Ile Leu Asn His Met Lys Arg 
225                 230                 235                 240 


Ala Thr Gln Ile Pro Ser Tyr Lys Lys Leu Ile Met Tyr Ser Ala His 
                245                 250                 255     


Asp Thr Thr Val Ser Gly Leu Gln Met Ala Leu Asp Val Tyr Asn Gly 
            260                 265                 270         


Leu Leu Pro Pro Tyr Ala Ser Cys His Leu Thr Glu Leu Tyr Phe Glu 
        275                 280                 285             


Lys Gly Glu Tyr Phe Val Glu Met Tyr Tyr Arg Asn Glu Thr Gln His 
    290                 295                 300                 


Glu Pro Tyr Pro Leu Met Leu Pro Gly Cys Ser Pro Ser Cys Pro Leu 
305                 310                 315                 320 


Glu Arg Phe Ala Glu Leu Val Gly Pro Val Ile Pro Gln Asp Trp Ser 
                325                 330                 335     


Thr Glu Cys Met Thr Thr Asn Ser His Gln Gly Thr Glu Asp Ser Thr 
            340                 345                 350         


Asp 
    


<210>  164
<211>  418
<212>  PRT
<213>  Homo Sapiens

<400>  164

Met Arg Ala Ala Pro Leu Leu Leu Ala Arg Ala Ala Ser Leu Ser Leu 
1               5                   10                  15      


Gly Phe Leu Phe Leu Leu Phe Phe Trp Leu Asp Arg Ser Val Leu Ala 
            20                  25                  30          


Lys Glu Leu Lys Phe Val Thr Leu Val Phe Arg His Gly Asp Arg Ser 
        35                  40                  45              


Pro Ile Asp Thr Phe Pro Thr Asp Pro Ile Lys Glu Ser Ser Trp Pro 
    50                  55                  60                  


Gln Gly Phe Gly Gln Leu Thr Gln Leu Gly Met Glu Gln His Tyr Glu 
65                  70                  75                  80  


Leu Gly Glu Tyr Ile Arg Lys Arg Tyr Arg Lys Phe Leu Asn Glu Ser 
                85                  90                  95      


Tyr Lys His Glu Gln Val Tyr Ile Arg Ser Thr Asp Val Asp Arg Thr 
            100                 105                 110         


Leu Met Ser Ala Met Thr Asn Leu Ala Ala Leu Phe Pro Pro Glu Gly 
        115                 120                 125             


Val Ser Ile Trp Asn Pro Ile Leu Leu Trp Gln Pro Ile Pro Val His 
    130                 135                 140                 


Thr Val Pro Leu Ser Glu Asp Gln Leu Leu Tyr Leu Pro Phe Arg Asn 
145                 150                 155                 160 


Cys Pro Arg Phe Gln Glu Leu Glu Ser Glu Thr Leu Lys Ser Glu Glu 
                165                 170                 175     


Phe Gln Lys Arg Leu His Pro Tyr Lys Asp Phe Ile Ala Thr Leu Gly 
            180                 185                 190         


Lys Leu Ser Gly Leu His Gly Gln Asp Leu Phe Gly Ile Trp Ser Lys 
        195                 200                 205             


Val Tyr Asp Pro Leu Tyr Cys Glu Ser Val His Asn Phe Thr Leu Pro 
    210                 215                 220                 


Ser Trp Ala Thr Glu Asp Thr Met Thr Lys Leu Arg Glu Leu Ser Glu 
225                 230                 235                 240 


Leu Ser Leu Leu Ser Leu Tyr Gly Ile His Lys Gln Lys Glu Lys Ser 
                245                 250                 255     


Arg Leu Gln Gly Gly Val Leu Val Asn Glu Ile Leu Asn His Met Lys 
            260                 265                 270         


Arg Ala Thr Gln Ile Pro Ser Tyr Lys Lys Leu Ile Met Tyr Ser Ala 
        275                 280                 285             


His Asp Thr Thr Val Ser Gly Leu Gln Met Ala Leu Asp Val Tyr Asn 
    290                 295                 300                 


Gly Leu Leu Pro Pro Tyr Ala Ser Cys His Leu Thr Glu Leu Tyr Phe 
305                 310                 315                 320 


Glu Lys Gly Glu Tyr Phe Val Glu Met Tyr Tyr Arg Asn Glu Thr Gln 
                325                 330                 335     


His Glu Pro Tyr Pro Leu Met Leu Pro Gly Cys Ser Pro Ser Cys Pro 
            340                 345                 350         


Leu Glu Arg Phe Ala Glu Leu Val Gly Pro Val Ile Pro Gln Asp Trp 
        355                 360                 365             


Ser Thr Glu Cys Met Thr Thr Asn Ser His Gln Val Leu Lys Val Ile 
    370                 375                 380                 


Phe Ala Val Ala Phe Cys Leu Ile Ser Ala Val Leu Met Val Leu Leu 
385                 390                 395                 400 


Phe Ile His Ile Arg Arg Gly Leu Cys Trp Gln Arg Glu Ser Tyr Gly 
                405                 410                 415     


Asn Ile 
        


<210>  165
<211>  386
<212>  PRT
<213>  Homo Sapiens

<400>  165

Met Arg Ala Ala Pro Leu Leu Leu Ala Arg Ala Ala Ser Leu Ser Leu 
1               5                   10                  15      


Gly Phe Leu Phe Leu Leu Phe Phe Trp Leu Asp Arg Ser Val Leu Ala 
            20                  25                  30          


Lys Glu Leu Lys Phe Val Thr Leu Val Phe Arg His Gly Asp Arg Ser 
        35                  40                  45              


Pro Ile Asp Thr Phe Pro Thr Asp Pro Ile Lys Glu Ser Ser Trp Pro 
    50                  55                  60                  


Gln Gly Phe Gly Gln Leu Thr Gln Leu Gly Met Glu Gln His Tyr Glu 
65                  70                  75                  80  


Leu Gly Glu Tyr Ile Arg Lys Arg Tyr Arg Lys Phe Leu Asn Glu Ser 
                85                  90                  95      


Tyr Lys His Glu Gln Val Tyr Ile Arg Ser Thr Asp Val Asp Arg Thr 
            100                 105                 110         


Leu Met Ser Ala Met Thr Asn Leu Ala Ala Leu Phe Pro Pro Glu Gly 
        115                 120                 125             


Val Ser Ile Trp Asn Pro Ile Leu Leu Trp Gln Pro Ile Pro Val His 
    130                 135                 140                 


Thr Val Pro Leu Ser Glu Asp Gln Leu Leu Tyr Leu Pro Phe Arg Asn 
145                 150                 155                 160 


Cys Pro Arg Phe Gln Glu Leu Glu Ser Glu Thr Leu Lys Ser Glu Glu 
                165                 170                 175     


Phe Gln Lys Arg Leu His Pro Tyr Lys Asp Phe Ile Ala Thr Leu Gly 
            180                 185                 190         


Lys Leu Ser Gly Leu His Gly Gln Asp Leu Phe Gly Ile Trp Ser Lys 
        195                 200                 205             


Val Tyr Asp Pro Leu Tyr Cys Glu Ser Val His Asn Phe Thr Leu Pro 
    210                 215                 220                 


Ser Trp Ala Thr Glu Asp Thr Met Thr Lys Leu Arg Glu Leu Ser Glu 
225                 230                 235                 240 


Leu Ser Leu Leu Ser Leu Tyr Gly Ile His Lys Gln Lys Glu Lys Ser 
                245                 250                 255     


Arg Leu Gln Gly Gly Val Leu Val Asn Glu Ile Leu Asn His Met Lys 
            260                 265                 270         


Arg Ala Thr Gln Ile Pro Ser Tyr Lys Lys Leu Ile Met Tyr Ser Ala 
        275                 280                 285             


His Asp Thr Thr Val Ser Gly Leu Gln Met Ala Leu Asp Val Tyr Asn 
    290                 295                 300                 


Gly Leu Leu Pro Pro Tyr Ala Ser Cys His Leu Thr Glu Leu Tyr Phe 
305                 310                 315                 320 


Glu Lys Gly Glu Tyr Phe Val Glu Met Tyr Tyr Arg Asn Glu Thr Gln 
                325                 330                 335     


His Glu Pro Tyr Pro Leu Met Leu Pro Gly Cys Ser Pro Ser Cys Pro 
            340                 345                 350         


Leu Glu Arg Phe Ala Glu Leu Val Gly Pro Val Ile Pro Gln Asp Trp 
        355                 360                 365             


Ser Thr Glu Cys Met Thr Thr Asn Ser His Gln Gly Thr Glu Asp Ser 
    370                 375                 380                 


Thr Asp 
385     


<210>  166
<211>  165
<212>  PRT
<213>  Homo Sapiens

<400>  166

Met Arg Ala Ala Pro Leu Leu Leu Ala Arg Ala Ala Ser Leu Ser Leu 
1               5                   10                  15      


Gly Phe Leu Phe Leu Leu Phe Phe Trp Leu Asp Arg Ser Val Leu Ala 
            20                  25                  30          


Lys Glu Leu Lys Phe Val Thr Leu Val Phe Arg His Gly Asp Arg Ser 
        35                  40                  45              


Pro Ile Asp Thr Phe Pro Thr Asp Pro Ile Lys Glu Ser Ser Trp Pro 
    50                  55                  60                  


Gln Gly Phe Gly Gln Leu Thr Gln Val Tyr Ile Arg Ser Thr Asp Val 
65                  70                  75                  80  


Asp Arg Thr Leu Met Ser Ala Met Thr Asn Leu Ala Ala Leu Phe Pro 
                85                  90                  95      


Pro Glu Gly Val Ser Ile Trp Asn Pro Ile Leu Leu Trp Gln Pro Ile 
            100                 105                 110         


Pro Val His Thr Val Pro Leu Ser Glu Asp Gln Leu Leu Tyr Leu Pro 
        115                 120                 125             


Phe Arg Asn Cys Pro Arg Phe Gln Glu Leu Glu Ser Glu Thr Leu Lys 
    130                 135                 140                 


Ser Glu Glu Phe Gln Lys Arg Leu His Pro Tyr Lys Asp Phe Ile Ala 
145                 150                 155                 160 


Thr Leu Gly Lys Leu 
                165 


<210>  167
<211>  99
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  167

Xaa Glu Leu Tyr Phe Glu Lys Gly Glu Tyr Phe Val Glu Met Tyr Tyr 
1               5                   10                  15      


Arg Asn Glu Thr Gln His Glu Pro Tyr Pro Leu Met Leu Pro Gly Cys 
            20                  25                  30          


Ser Pro Ser Cys Pro Leu Glu Arg Phe Ala Glu Leu Val Gly Pro Val 
        35                  40                  45              


Ile Pro Gln Asp Trp Ser Thr Glu Cys Met Thr Thr Asn Ser His Gln 
    50                  55                  60                  


Gly Pro Ala Glu Thr Ala His Ser Ala Arg Arg Asn His Asp Ile Ala 
65                  70                  75                  80  


Leu Pro Cys Gly Arg Ser Thr Cys Leu Glu Asn Thr Val Leu Tyr Tyr 
                85                  90                  95      


His Tyr Gly 
            


<210>  168
<211>  421
<212>  PRT
<213>  Homo Sapiens

<400>  168

Met Val Glu Met Leu Pro Thr Ala Ile Leu Leu Val Leu Ala Val Ser 
1               5                   10                  15      


Val Val Ala Lys Asp Asn Ala Thr Cys Asp Gly Pro Cys Gly Leu Arg 
            20                  25                  30          


Phe Arg Gln Asn Pro Gln Gly Gly Val Arg Ile Val Gly Gly Lys Ala 
        35                  40                  45              


Ala Gln His Gly Ala Trp Pro Trp Met Val Ser Leu Gln Ile Phe Thr 
    50                  55                  60                  


Tyr Asn Ser His Arg Tyr His Thr Cys Gly Gly Ser Leu Leu Asn Ser 
65                  70                  75                  80  


Arg Trp Val Leu Thr Ala Ala His Cys Phe Val Gly Lys Asn Asn Val 
                85                  90                  95      


His Asp Trp Arg Leu Val Phe Gly Ala Lys Glu Ile Thr Tyr Gly Asn 
            100                 105                 110         


Asn Lys Pro Val Lys Ala Pro Leu Gln Glu Arg Tyr Val Glu Lys Ile 
        115                 120                 125             


Ile Ile His Glu Lys Tyr Asn Ser Ala Thr Glu Gly Asn Asp Ile Ala 
    130                 135                 140                 


Leu Val Glu Ile Thr Pro Pro Ile Ser Cys Gly Arg Phe Ile Gly Pro 
145                 150                 155                 160 


Gly Cys Leu Pro His Phe Lys Ala Gly Leu Pro Arg Gly Ser Gln Ser 
                165                 170                 175     


Cys Trp Val Ala Gly Trp Gly Tyr Ile Glu Glu Lys Ala Pro Arg Pro 
            180                 185                 190         


Ser Ser Ile Leu Met Glu Ala Arg Val Asp Leu Ile Asp Leu Asp Leu 
        195                 200                 205             


Cys Asn Ser Thr Gln Trp Tyr Asn Gly Arg Val Gln Pro Thr Asn Val 
    210                 215                 220                 


Cys Ala Gly Tyr Pro Val Gly Lys Ile Asp Thr Cys Gln Gly Asp Ser 
225                 230                 235                 240 


Gly Gly Pro Leu Met Cys Lys Asp Ser Lys Glu Ser Ala Tyr Val Val 
                245                 250                 255     


Val Gly Ile Thr Ser Trp Gly Val Gly Cys Ala Arg Ala Lys Arg Pro 
            260                 265                 270         


Gly Ile Tyr Thr Ala Thr Trp Pro Tyr Leu Asn Trp Ile Ala Ser Lys 
        275                 280                 285             


Ile Gly Ser Asn Ala Leu Arg Met Ile Gln Ser Ala Thr Pro Pro Pro 
    290                 295                 300                 


Pro Thr Thr Arg Pro Pro Pro Ile Arg Pro Pro Phe Ser His Pro Ile 
305                 310                 315                 320 


Ser Ala His Leu Pro Trp Tyr Phe Gln Pro Pro Pro Arg Pro Leu Pro 
                325                 330                 335     


Pro Arg Pro Pro Ala Ala Gln Pro Arg Pro Pro Pro Ser Pro Pro Pro 
            340                 345                 350         


Pro Pro Pro Pro Pro Ala Ser Pro Leu Pro Pro Pro Pro Pro Pro Pro 
        355                 360                 365             


Pro Pro Thr Pro Ser Ser Thr Thr Lys Leu Pro Gln Gly Leu Ser Phe 
    370                 375                 380                 


Ala Lys Arg Leu Gln Gln Leu Ile Glu Val Leu Lys Gly Lys Thr Tyr 
385                 390                 395                 400 


Ser Asp Gly Lys Asn His Tyr Asp Met Glu Thr Thr Glu Leu Pro Glu 
                405                 410                 415     


Leu Thr Ser Thr Ser 
            420     


<210>  169
<211>  212
<212>  PRT
<213>  Homo Sapiens

<400>  169

Met Val Glu Met Leu Pro Thr Ala Ile Leu Leu Val Leu Ala Val Ser 
1               5                   10                  15      


Val Val Ala Lys Asp Asn Ala Thr Cys Asp Gly Pro Cys Gly Leu Arg 
            20                  25                  30          


Phe Arg Gln Asn Pro Gln Gly Gly Val Arg Ile Val Gly Gly Lys Ala 
        35                  40                  45              


Ala Gln His Gly Ala Trp Pro Trp Met Val Ser Leu Gln Ile Phe Thr 
    50                  55                  60                  


Tyr Asn Ser His Arg Tyr His Thr Cys Gly Gly Ser Leu Leu Asn Ser 
65                  70                  75                  80  


Arg Trp Val Leu Thr Ala Ala His Cys Phe Val Gly Lys Asn Asn Val 
                85                  90                  95      


His Asp Trp Arg Leu Val Phe Gly Ala Lys Glu Ile Thr Tyr Gly Asn 
            100                 105                 110         


Asn Lys Pro Val Lys Ala Pro Leu Gln Glu Arg Tyr Val Glu Lys Ile 
        115                 120                 125             


Ile Ile His Glu Lys Tyr Asn Ser Ala Thr Glu Gly Asn Asp Ile Ala 
    130                 135                 140                 


Leu Val Glu Ile Thr Pro Pro Ile Ser Cys Gly Arg Phe Ile Gly Pro 
145                 150                 155                 160 


Gly Cys Leu Pro His Phe Lys Ala Gly Leu Pro Arg Gly Ser Gln Ser 
                165                 170                 175     


Cys Trp Val Ala Gly Trp Gly Tyr Ile Glu Glu Lys Gly Phe Leu Glu 
            180                 185                 190         


Cys Pro Ala Gly Thr Ser Pro Phe Lys Thr Gly Val Ala Val Ala Leu 
        195                 200                 205             


Glu Leu Cys Pro 
    210         


<210>  170
<211>  100
<212>  PRT
<213>  Homo Sapiens

<400>  170

Met Arg Lys Pro Ala Ala Gly Phe Leu Pro Ser Leu Leu Lys Val Leu 
1               5                   10                  15      


Leu Leu Pro Leu Ala Pro Ala Ala Ala Gln Asp Ser Thr Gln Ala Ser 
            20                  25                  30          


Thr Pro Gly Ser Pro Leu Ser Pro Thr Glu Tyr Glu Arg Phe Phe Ala 
        35                  40                  45              


Leu Leu Thr Pro Thr Trp Lys Ala Glu Thr Thr Cys Arg Leu Arg Ala 
    50                  55                  60                  


Thr His Gly Cys Arg Asn Pro Thr Leu Val Gln Leu Asp Gln Tyr Glu 
65                  70                  75                  80  


Asn His Gly Leu Val Pro Asp Glu Ser Pro Val Phe Pro Ala Ser Leu 
                85                  90                  95      


Tyr Ser Leu Thr 
            100 


<210>  171
<211>  510
<212>  PRT
<213>  Homo Sapiens

<400>  171

Met Arg Lys Pro Ala Ala Gly Phe Leu Pro Ser Leu Leu Lys Val Leu 
1               5                   10                  15      


Leu Leu Pro Leu Ala Pro Ala Ala Ala Gln Asp Ser Thr Gln Ala Ser 
            20                  25                  30          


Thr Pro Gly Ser Pro Leu Ser Pro Thr Glu Tyr Glu Arg Phe Phe Ala 
        35                  40                  45              


Leu Leu Thr Pro Thr Trp Lys Ala Glu Thr Thr Cys Arg Leu Arg Ala 
    50                  55                  60                  


Thr His Gly Cys Arg Asn Pro Thr Leu Val Gln Leu Asp Gln Tyr Glu 
65                  70                  75                  80  


Asn His Gly Leu Val Pro Asp Gly Ala Val Cys Ser Asn Leu Pro Tyr 
                85                  90                  95      


Ala Ser Trp Phe Glu Ser Phe Cys Gln Phe Thr His Tyr Arg Cys Ser 
            100                 105                 110         


Asn His Val Tyr Tyr Ala Lys Arg Val Leu Cys Ser Gln Pro Val Ser 
        115                 120                 125             


Ile Leu Ser Pro Asn Thr Leu Lys Glu Ile Glu Ala Ser Ala Glu Val 
    130                 135                 140                 


Ser Pro Thr Thr Met Thr Ser Pro Ile Ser Pro His Phe Thr Ala Pro 
145                 150                 155                 160 


Glu His Lys Gln Glu Gln Gly Val Glu His Arg Gln Glu Pro Thr Gln 
                165                 170                 175     


Glu His Lys Gln Glu Glu Gly Gln Lys Gln Glu Glu Gln Glu Glu Glu 
            180                 185                 190         


Gln Glu Glu Glu Gly Lys Gln Glu Glu Gly Gln Gly Thr Lys Glu Gly 
        195                 200                 205             


Arg Glu Ala Val Ser Gln Leu Gln Thr Asp Ser Glu Pro Lys Phe His 
    210                 215                 220                 


Ser Glu Ser Leu Ser Ser Asn Pro Ser Ser Phe Ala Pro Arg Val Arg 
225                 230                 235                 240 


Glu Val Glu Ser Thr Pro Met Ile Met Glu Asn Ile Gln Glu Leu Ile 
                245                 250                 255     


Arg Ser Ala Gln Glu Ile Asp Glu Met Asn Glu Ile Tyr Asp Glu Asn 
            260                 265                 270         


Ser Tyr Trp Arg Asn Gln Asn Pro Gly Ser Leu Leu Gln Leu Pro His 
        275                 280                 285             


Thr Glu Ala Leu Leu Val Leu Cys Tyr Ser Ile Val Glu Asn Thr Cys 
    290                 295                 300                 


Ile Ile Thr Pro Thr Ala Lys Ala Trp Lys Tyr Met Glu Glu Glu Ile 
305                 310                 315                 320 


Leu Gly Phe Gly Lys Ser Val Cys Asp Ser Leu Gly Arg Arg His Met 
                325                 330                 335     


Ser Thr Cys Ala Leu Cys Asp Phe Cys Ser Leu Lys Leu Glu Gln Cys 
            340                 345                 350         


His Ser Glu Ala Ser Leu Gln Arg Gln Gln Cys Asp Thr Ser His Lys 
        355                 360                 365             


Thr Pro Phe Val Ser Pro Leu Leu Ala Ser Gln Ser Leu Ser Ile Gly 
    370                 375                 380                 


Asn Gln Val Gly Ser Pro Glu Ser Gly Arg Phe Tyr Gly Leu Asp Leu 
385                 390                 395                 400 


Tyr Gly Gly Leu His Met Asp Phe Trp Cys Ala Arg Leu Ala Thr Lys 
                405                 410                 415     


Gly Cys Glu Asp Val Arg Val Ser Gly Trp Leu Gln Thr Glu Phe Leu 
            420                 425                 430         


Ser Phe Gln Asp Gly Asp Phe Pro Thr Lys Ile Cys Asp Thr Asp Tyr 
        435                 440                 445             


Ile Gln Tyr Pro Asn Tyr Cys Ser Phe Lys Ser Gln Gln Cys Leu Met 
    450                 455                 460                 


Arg Asn Arg Asn Arg Lys Val Ser Arg Met Arg Cys Leu Gln Asn Glu 
465                 470                 475                 480 


Thr Tyr Ser Ala Leu Ser Pro Gly Lys Ser Glu Asp Val Val Leu Arg 
                485                 490                 495     


Trp Ser Gln Glu Phe Ser Thr Leu Thr Leu Gly Gln Phe Gly 
            500                 505                 510 


<210>  172
<211>  174
<212>  PRT
<213>  Homo Sapiens

<400>  172

Met Arg Lys Pro Ala Ala Gly Phe Leu Pro Ser Leu Leu Lys Val Leu 
1               5                   10                  15      


Leu Leu Pro Leu Ala Pro Ala Ala Ala Gln Asp Ser Thr Gln Ala Ser 
            20                  25                  30          


Thr Pro Gly Ser Pro Leu Ser Pro Thr Glu Tyr Glu Arg Phe Phe Ala 
        35                  40                  45              


Leu Leu Thr Pro Thr Trp Lys Ala Glu Thr Thr Cys Arg Leu Arg Ala 
    50                  55                  60                  


Thr His Gly Cys Arg Asn Pro Thr Leu Val Gln Leu Asp Gln Tyr Glu 
65                  70                  75                  80  


Asn His Gly Leu Val Pro Asp Gly Ala Val Cys Ser Asn Leu Pro Tyr 
                85                  90                  95      


Ala Ser Trp Phe Glu Ser Phe Cys Gln Phe Thr His Tyr Arg Cys Ser 
            100                 105                 110         


Asn His Val Tyr Tyr Ala Lys Arg Val Leu Cys Ser Gln Pro Val Ser 
        115                 120                 125             


Ile Leu Ser Pro Asn Thr Leu Lys Glu Ile Glu Ala Ser Ala Glu Val 
    130                 135                 140                 


Ser Pro Thr Thr Met Thr Ser Pro Ile Ser Pro His Phe Thr Glu Arg 
145                 150                 155                 160 


Gln Thr Phe Gln Pro Trp Pro Glu Arg Leu Ser Asn Asn Val 
                165                 170                 


<210>  173
<211>  543
<212>  PRT
<213>  Homo Sapiens

<400>  173

Met Arg Lys Pro Ala Ala Gly Phe Leu Pro Ser Leu Leu Lys Val Leu 
1               5                   10                  15      


Leu Leu Pro Leu Ala Pro Ala Ala Ala Gln Asp Ser Thr Gln Ala Ser 
            20                  25                  30          


Thr Pro Gly Ser Pro Leu Ser Pro Thr Glu Tyr Glu Arg Phe Phe Ala 
        35                  40                  45              


Leu Leu Thr Pro Thr Trp Lys Ala Glu Thr Thr Cys Arg Leu Arg Ala 
    50                  55                  60                  


Thr His Gly Cys Arg Asn Pro Thr Leu Val Gln Leu Asp Gln Tyr Glu 
65                  70                  75                  80  


Asn His Gly Leu Val Pro Asp Gly Ala Val Cys Ser Asn Leu Pro Tyr 
                85                  90                  95      


Ala Ser Trp Phe Glu Ser Phe Cys Gln Phe Thr His Tyr Arg Cys Ser 
            100                 105                 110         


Asn His Val Tyr Tyr Ala Lys Arg Val Leu Cys Ser Gln Pro Val Ser 
        115                 120                 125             


Ile Leu Ser Pro Asn Thr Leu Lys Glu Ile Glu Ala Ser Ala Glu Val 
    130                 135                 140                 


Ser Pro Thr Thr Met Thr Ser Pro Ile Ser Pro His Phe Thr Val Thr 
145                 150                 155                 160 


Glu Arg Gln Thr Phe Gln Pro Trp Pro Glu Arg Leu Ser Asn Asn Val 
                165                 170                 175     


Glu Glu Leu Leu Gln Ser Ser Leu Ser Leu Gly Gly Gln Glu Gln Ala 
            180                 185                 190         


Pro Glu His Lys Gln Glu Gln Gly Val Glu His Arg Gln Glu Pro Thr 
        195                 200                 205             


Gln Glu His Lys Gln Glu Glu Gly Gln Lys Gln Glu Glu Gln Glu Glu 
    210                 215                 220                 


Glu Gln Glu Glu Glu Gly Lys Gln Glu Glu Gly Gln Gly Thr Lys Glu 
225                 230                 235                 240 


Gly Arg Glu Ala Val Ser Gln Leu Gln Thr Asp Ser Glu Pro Lys Phe 
                245                 250                 255     


His Ser Glu Ser Leu Ser Ser Asn Pro Ser Ser Phe Ala Pro Arg Val 
            260                 265                 270         


Arg Glu Val Glu Ser Thr Pro Met Ile Met Glu Asn Ile Gln Glu Leu 
        275                 280                 285             


Ile Arg Ser Ala Gln Glu Ile Asp Glu Met Asn Glu Ile Tyr Asp Glu 
    290                 295                 300                 


Asn Ser Tyr Trp Arg Asn Gln Asn Pro Gly Ser Leu Leu Gln Leu Pro 
305                 310                 315                 320 


His Thr Glu Ala Leu Leu Val Leu Cys Tyr Ser Ile Val Glu Asn Thr 
                325                 330                 335     


Cys Ile Ile Thr Pro Thr Ala Lys Ala Trp Lys Tyr Met Glu Glu Glu 
            340                 345                 350         


Ile Leu Gly Phe Gly Lys Ser Val Cys Asp Ser Leu Gly Arg Arg His 
        355                 360                 365             


Met Ser Thr Cys Ala Leu Cys Asp Phe Cys Ser Leu Lys Leu Glu Gln 
    370                 375                 380                 


Cys His Ser Glu Ala Ser Leu Gln Arg Gln Gln Cys Asp Thr Ser His 
385                 390                 395                 400 


Lys Thr Pro Phe Val Ser Pro Leu Leu Ala Ser Gln Ser Leu Ser Ile 
                405                 410                 415     


Gly Asn Gln Val Gly Ser Pro Glu Ser Gly Arg Phe Tyr Gly Leu Asp 
            420                 425                 430         


Leu Tyr Gly Gly Leu His Met Asp Phe Trp Cys Ala Arg Leu Ala Thr 
        435                 440                 445             


Lys Gly Cys Glu Asp Val Arg Val Ser Gly Trp Leu Gln Thr Glu Phe 
    450                 455                 460                 


Leu Ser Phe Gln Asp Gly Asp Phe Pro Thr Lys Ile Cys Asp Thr Asp 
465                 470                 475                 480 


Tyr Ile Gln Tyr Pro Asn Tyr Cys Ser Phe Lys Ser Gln Gln Cys Leu 
                485                 490                 495     


Met Arg Asn Arg Asn Arg Lys Val Ser Arg Met Arg Cys Leu Gln Asn 
            500                 505                 510         


Glu Thr Tyr Ser Ala Leu Ser Pro Gly Lys Ser Glu Asp Val Val Leu 
        515                 520                 525             


Arg Trp Ser Gln Glu Phe Ser Thr Leu Thr Leu Gly Gln Phe Gly 
    530                 535                 540             


<210>  174
<211>  319
<212>  PRT
<213>  Homo Sapiens

<400>  174

Met Arg Lys Pro Ala Ala Gly Phe Leu Pro Ser Leu Leu Lys Val Leu 
1               5                   10                  15      


Leu Leu Pro Leu Ala Pro Ala Ala Ala Gln Asp Ser Thr Gln Ala Ser 
            20                  25                  30          


Thr Pro Gly Ser Pro Leu Ser Pro Thr Glu Tyr Glu Arg Phe Phe Ala 
        35                  40                  45              


Leu Leu Thr Pro Thr Trp Lys Ala Glu Thr Thr Cys Arg Leu Arg Ala 
    50                  55                  60                  


Thr His Gly Cys Arg Asn Pro Thr Leu Val Gln Leu Asp Gln Tyr Glu 
65                  70                  75                  80  


Asn His Gly Leu Val Pro Asp Gly Ala Val Cys Ser Asn Leu Pro Tyr 
                85                  90                  95      


Ala Ser Trp Phe Glu Ser Phe Cys Gln Phe Thr His Tyr Arg Cys Ser 
            100                 105                 110         


Asn His Val Tyr Tyr Ala Lys Arg Val Leu Cys Ser Gln Pro Val Ser 
        115                 120                 125             


Ile Leu Ser Pro Asn Thr Leu Lys Glu Ile Glu Ala Ser Ala Glu Val 
    130                 135                 140                 


Ser Pro Thr Thr Met Thr Ser Pro Ile Ser Pro His Phe Thr Val Thr 
145                 150                 155                 160 


Glu Arg Gln Thr Phe Gln Pro Trp Pro Glu Arg Leu Ser Asn Asn Val 
                165                 170                 175     


Glu Glu Leu Leu Gln Ser Ser Leu Ser Leu Gly Gly Gln Glu Gln Ala 
            180                 185                 190         


Pro Glu His Lys Gln Glu Gln Gly Val Glu His Arg Gln Glu Pro Thr 
        195                 200                 205             


Gln Glu His Lys Gln Glu Glu Gly Gln Lys Gln Glu Glu Gln Glu Glu 
    210                 215                 220                 


Glu Gln Glu Glu Glu Gly Lys Gln Glu Glu Gly Gln Gly Thr Lys Glu 
225                 230                 235                 240 


Gly Arg Glu Ala Val Ser Gln Leu Gln Thr Asp Ser Glu Pro Lys Phe 
                245                 250                 255     


His Ser Glu Ser Leu Ser Ser Asn Pro Ser Ser Phe Ala Pro Arg Val 
            260                 265                 270         


Arg Glu Val Glu Ser Thr Pro Met Ile Met Glu Asn Ile Gln Glu Leu 
        275                 280                 285             


Ile Arg Ser Ala Gln Glu Ile Asp Glu Met Asn Glu Ile Tyr Asp Glu 
    290                 295                 300                 


Asn Ser Tyr Trp Arg Asn Gln Asn Pro Gly Arg Tyr Arg Lys Phe 
305                 310                 315                 


<210>  175
<211>  265
<212>  PRT
<213>  Homo Sapiens

<400>  175

Met Asn Arg Phe Leu Leu Leu Met Ser Leu Tyr Leu Leu Gly Ser Ala 
1               5                   10                  15      


Arg Gly Thr Ser Ser Gln Pro Asn Glu Leu Ser Gly Ser Ile Asp His 
            20                  25                  30          


Gln Thr Ser Val Gln Gln Leu Pro Gly Glu Phe Phe Ser Leu Glu Asn 
        35                  40                  45              


Pro Ser Asp Ala Glu Ala Leu Tyr Glu Thr Ser Ser Gly Leu Asn Thr 
    50                  55                  60                  


Leu Ser Glu His Gly Ser Ser Glu His Gly Ser Ser Lys His Thr Val 
65                  70                  75                  80  


Ala Glu His Thr Ser Gly Glu His Ala Glu Ser Glu His Ala Ser Gly 
                85                  90                  95      


Glu Pro Ala Ala Thr Glu His Ala Glu Gly Glu His Thr Val Gly Glu 
            100                 105                 110         


Gln Pro Ser Gly Glu Gln Pro Ser Gly Glu His Leu Ser Gly Glu Gln 
        115                 120                 125             


Pro Leu Ser Glu Leu Glu Ser Gly Glu Gln Pro Ser Asp Glu Gln Pro 
    130                 135                 140                 


Ser Gly Glu His Gly Ser Gly Glu Gln Pro Ser Gly Glu Gln Ala Ser 
145                 150                 155                 160 


Gly Glu Gln Pro Ser Gly Glu His Ala Ser Gly Glu Gln Ala Ser Gly 
                165                 170                 175     


Ala Pro Ile Ser Ser Thr Ser Thr Gly Thr Ile Leu Asn Cys Tyr Thr 
            180                 185                 190         


Cys Ala Tyr Met Asn Asp Gln Gly Lys Cys Leu Arg Gly Glu Gly Thr 
        195                 200                 205             


Cys Ile Thr Gln Asn Ser Gln Gln Cys Met Leu Lys Lys Ile Phe Glu 
    210                 215                 220                 


Gly Gly Lys Leu Gln Phe Met Val Gln Gly Cys Glu Asn Met Cys Pro 
225                 230                 235                 240 


Ser Met Asn Leu Phe Ser His Gly Thr Arg Met Gln Ile Ile Cys Cys 
                245                 250                 255     


Arg Asn Gln Ser Phe Cys Asn Lys Ile 
            260                 265 


<210>  176
<211>  246
<212>  PRT
<213>  Homo Sapiens

<400>  176

Met Asn Arg Phe Leu Leu Leu Met Ser Leu Tyr Leu Leu Gly Ser Ala 
1               5                   10                  15      


Arg Gly Thr Ser Ser Gln Pro Asn Glu Leu Ser Gly Ser Ile Asp His 
            20                  25                  30          


Gln Thr Ser Val Gln Gln Leu Pro Gly Glu Phe Phe Ser Leu Glu Asn 
        35                  40                  45              


Pro Ser Asp Ala Glu Ala Leu Tyr Glu Thr Ser Ser Gly Leu Asn Thr 
    50                  55                  60                  


Leu Ser Glu His Gly Ser Ser Glu His Gly Ser Ser Lys His Thr Val 
65                  70                  75                  80  


Ala Glu His Thr Ser Gly Glu His Ala Glu Ser Glu His Ala Ser Gly 
                85                  90                  95      


Glu Pro Ala Ala Thr Glu His Ala Glu Gly Glu His Thr Val Gly Glu 
            100                 105                 110         


Gln Pro Ser Gly Glu Gln Pro Ser Gly Glu His Leu Ser Gly Glu Gln 
        115                 120                 125             


Pro Leu Ser Glu Leu Glu Ser Gly Glu Gln Pro Ser Asp Glu Gln Pro 
    130                 135                 140                 


Ser Gly Glu His Gly Ser Gly Glu Gln Pro Ser Gly Glu Gln Ala Ser 
145                 150                 155                 160 


Gly Glu Gln Pro Ser Gly Thr Ile Leu Asn Cys Tyr Thr Cys Ala Tyr 
                165                 170                 175     


Met Asn Asp Gln Gly Lys Cys Leu Arg Gly Glu Gly Thr Cys Ile Thr 
            180                 185                 190         


Gln Asn Ser Gln Gln Cys Met Leu Lys Lys Ile Phe Glu Gly Gly Lys 
        195                 200                 205             


Leu Gln Phe Met Val Gln Gly Cys Glu Asn Met Cys Pro Ser Met Asn 
    210                 215                 220                 


Leu Phe Ser His Gly Thr Arg Met Gln Ile Ile Cys Cys Arg Asn Gln 
225                 230                 235                 240 


Ser Phe Cys Asn Lys Ile 
                245     


<210>  177
<211>  210
<212>  PRT
<213>  Homo Sapiens

<400>  177

Met Asn Arg Phe Leu Leu Leu Met Ser Leu Tyr Leu Leu Gly Ser Ala 
1               5                   10                  15      


Arg Gly Thr Ser Ser Gln Pro Asn Glu Leu Ser Gly Ser Ile Asp His 
            20                  25                  30          


Gln Thr Ser Val Gln Gln Leu Pro Gly Glu Pro Ala Ala Thr Glu His 
        35                  40                  45              


Ala Glu Gly Glu His Thr Val Gly Glu Gln Pro Ser Gly Glu Gln Pro 
    50                  55                  60                  


Ser Gly Glu His Leu Ser Gly Glu Gln Pro Leu Ser Glu Leu Glu Ser 
65                  70                  75                  80  


Gly Glu Gln Pro Ser Asp Glu Gln Pro Ser Gly Glu His Gly Ser Gly 
                85                  90                  95      


Glu Gln Pro Ser Gly Glu Gln Ala Ser Gly Glu Gln Pro Ser Gly Glu 
            100                 105                 110         


His Ala Ser Gly Glu Gln Ala Ser Gly Ala Pro Ile Ser Ser Thr Ser 
        115                 120                 125             


Thr Gly Thr Ile Leu Asn Cys Tyr Thr Cys Ala Tyr Met Asn Asp Gln 
    130                 135                 140                 


Gly Lys Cys Leu Arg Gly Glu Gly Thr Cys Ile Thr Gln Asn Ser Gln 
145                 150                 155                 160 


Gln Cys Met Leu Lys Lys Ile Phe Glu Gly Gly Lys Leu Gln Phe Met 
                165                 170                 175     


Val Gln Gly Cys Glu Asn Met Cys Pro Ser Met Asn Leu Phe Ser His 
            180                 185                 190         


Gly Thr Arg Met Gln Ile Ile Cys Cys Arg Asn Gln Ser Phe Cys Asn 
        195                 200                 205             


Lys Ile 
    210 


<210>  178
<211>  195
<212>  PRT
<213>  Homo Sapiens

<400>  178

Met Asn Arg Phe Leu Leu Leu Met Ser Leu Tyr Leu Leu Gly Ser Ala 
1               5                   10                  15      


Arg Gly Thr Ser Ser Gln Pro Asn Glu Leu Ser Gly Ser Ile Asp His 
            20                  25                  30          


Gln Thr Ser Val Gln Gln Leu Pro Gly Glu Gln Pro Ser Gly Glu Gln 
        35                  40                  45              


Pro Ser Gly Glu His Leu Ser Gly Glu Gln Pro Leu Ser Glu Leu Glu 
    50                  55                  60                  


Ser Gly Glu Gln Pro Ser Asp Glu Gln Pro Ser Gly Glu His Gly Ser 
65                  70                  75                  80  


Gly Glu Gln Pro Ser Gly Glu Gln Ala Ser Gly Glu Gln Pro Ser Gly 
                85                  90                  95      


Glu His Ala Ser Gly Glu Gln Ala Ser Gly Ala Pro Ile Ser Ser Thr 
            100                 105                 110         


Ser Thr Gly Thr Ile Leu Asn Cys Tyr Thr Cys Ala Tyr Met Asn Asp 
        115                 120                 125             


Gln Gly Lys Cys Leu Arg Gly Glu Gly Thr Cys Ile Thr Gln Asn Ser 
    130                 135                 140                 


Gln Gln Cys Met Leu Lys Lys Ile Phe Glu Gly Gly Lys Leu Gln Phe 
145                 150                 155                 160 


Met Val Gln Gly Cys Glu Asn Met Cys Pro Ser Met Asn Leu Phe Ser 
                165                 170                 175     


His Gly Thr Arg Met Gln Ile Ile Cys Cys Arg Asn Gln Ser Phe Cys 
            180                 185                 190         


Asn Lys Ile 
        195 


<210>  179
<211>  45
<212>  PRT
<213>  Homo Sapiens

<400>  179

Met Ala Val Tyr Val Gly Met Leu Arg Leu Gly Arg Leu Cys Ala Gly 
1               5                   10                  15      


Ser Ser Gly Val Leu Gly Ala Arg Ala Ala Leu Ser Arg Ser Trp Gln 
            20                  25                  30          


Glu Ala Arg Leu Gln Gly Val Arg Phe Leu Arg Cys Leu 
        35                  40                  45  


<210>  180
<211>  54
<212>  PRT
<213>  Homo Sapiens

<400>  180

Met Ala Val Tyr Val Gly Met Leu Arg Leu Gly Arg Leu Cys Ala Gly 
1               5                   10                  15      


Ser Ser Gly Val Leu Gly Ala Arg Ala Ala Leu Ser Arg Ser Trp Gln 
            20                  25                  30          


Glu Ala Arg Leu Gln Gly Val Arg Phe Leu Arg Pro Ser Gly Glu Lys 
        35                  40                  45              


Leu Ala His Gln Gly Val 
    50                  


<210>  181
<211>  640
<212>  PRT
<213>  Homo Sapiens

<400>  181

Met Ala Val Tyr Val Gly Met Leu Arg Leu Gly Arg Leu Cys Ala Gly 
1               5                   10                  15      


Ser Ser Gly Val Leu Gly Ala Arg Ala Ala Leu Ser Arg Ser Trp Gln 
            20                  25                  30          


Glu Ala Arg Leu Gln Gly Val Arg Phe Leu Ser Ala Arg Gly Gly Met 
        35                  40                  45              


Glu Ala Gly Arg Gln Arg Ile Ser Val Pro Ser Ser Phe Thr Ala Ser 
    50                  55                  60                  


Ala Ala Ala His Ser Arg Glu Val Asp Arg Met Val Ser Thr Pro Ile 
65                  70                  75                  80  


Gly Gly Leu Ser Tyr Val Gln Gly Cys Thr Lys Lys His Leu Asn Ser 
                85                  90                  95      


Lys Thr Val Gly Gln Cys Leu Glu Thr Thr Ala Gln Arg Val Pro Glu 
            100                 105                 110         


Arg Glu Ala Leu Val Val Leu His Glu Asp Val Arg Leu Thr Phe Ala 
        115                 120                 125             


Gln Leu Lys Glu Glu Val Asp Lys Ala Ala Ser Gly Leu Leu Ser Ile 
    130                 135                 140                 


Gly Leu Cys Lys Gly Asp Arg Leu Gly Met Trp Gly Pro Asn Ser Tyr 
145                 150                 155                 160 


Ala Trp Val Leu Met Gln Leu Ala Thr Ala Gln Ala Gly Ile Ile Leu 
                165                 170                 175     


Val Ser Val Asn Pro Ala Tyr Gln Ala Met Glu Leu Glu Tyr Val Leu 
            180                 185                 190         


Lys Lys Val Gly Cys Lys Ala Leu Val Phe Pro Lys Gln Phe Lys Thr 
        195                 200                 205             


Gln Gln Tyr Tyr Asn Val Leu Lys Gln Ile Cys Pro Glu Val Glu Asn 
    210                 215                 220                 


Ala Gln Pro Gly Ala Leu Lys Ser Gln Arg Leu Pro Asp Leu Thr Thr 
225                 230                 235                 240 


Val Ile Ser Val Asp Ala Pro Leu Pro Gly Thr Leu Leu Leu Asp Glu 
                245                 250                 255     


Val Val Ala Ala Gly Ser Thr Arg Gln His Leu Asp Gln Leu Gln Tyr 
            260                 265                 270         


Asn Gln Gln Phe Leu Ser Cys His Asp Pro Ile Asn Ile Gln Phe Thr 
        275                 280                 285             


Ser Gly Thr Thr Gly Ser Pro Lys Gly Ala Thr Leu Ser His Tyr Asn 
    290                 295                 300                 


Ile Val Asn Asn Ser Asn Ile Leu Gly Glu Arg Leu Lys Leu His Glu 
305                 310                 315                 320 


Lys Thr Pro Glu Gln Leu Arg Met Ile Leu Pro Asn Pro Leu Tyr His 
                325                 330                 335     


Cys Leu Gly Ser Val Ala Gly Thr Met Met Cys Leu Met Tyr Gly Ala 
            340                 345                 350         


Thr Leu Ile Leu Ala Ser Pro Ile Phe Asn Gly Lys Lys Ala Leu Glu 
        355                 360                 365             


Ala Ile Ser Arg Glu Arg Gly Thr Phe Leu Tyr Gly Thr Pro Thr Met 
    370                 375                 380                 


Phe Val Asp Ile Leu Asn Gln Pro Asp Phe Ser Ser Tyr Asp Ile Ser 
385                 390                 395                 400 


Thr Met Cys Gly Gly Val Ile Ala Gly Ser Pro Ala Pro Pro Glu Leu 
                405                 410                 415     


Ile Arg Ala Ile Ile Asn Lys Ile Asn Met Lys Asp Leu Val Val Ala 
            420                 425                 430         


Tyr Gly Thr Thr Glu Asn Ser Pro Val Thr Phe Ala His Phe Pro Glu 
        435                 440                 445             


Asp Thr Val Glu Gln Lys Ala Glu Ser Val Gly Arg Ile Met Pro His 
    450                 455                 460                 


Thr Glu Ala Arg Ile Met Asn Met Glu Ala Gly Thr Leu Ala Lys Leu 
465                 470                 475                 480 


Asn Thr Pro Gly Glu Leu Cys Ile Arg Gly Tyr Cys Val Met Leu Gly 
                485                 490                 495     


Tyr Trp Gly Glu Pro Gln Lys Thr Glu Glu Ala Val Asp Gln Asp Lys 
            500                 505                 510         


Trp Tyr Trp Thr Gly Asp Val Ala Thr Met Asn Glu Gln Gly Phe Cys 
        515                 520                 525             


Lys Ile Val Gly Arg Ser Lys Asp Met Ile Ile Arg Gly Gly Glu Asn 
    530                 535                 540                 


Ile Tyr Pro Ala Glu Leu Glu Asp Phe Phe His Thr His Pro Lys Val 
545                 550                 555                 560 


Gln Glu Val Gln Val Val Gly Val Lys Asp Asp Arg Met Gly Glu Glu 
                565                 570                 575     


Ile Cys Ala Cys Ile Arg Leu Lys Asp Gly Glu Glu Thr Thr Val Glu 
            580                 585                 590         


Glu Ile Lys Ala Phe Cys Lys Gly Lys Ile Ser His Phe Lys Ile Pro 
        595                 600                 605             


Lys Tyr Ile Val Phe Val Thr Asn Tyr Pro Leu Thr Ile Ser Gly Lys 
    610                 615                 620                 


Ile Gln Lys Phe Lys Leu Arg Glu Gln Met Glu Arg His Leu Asn Leu 
625                 630                 635                 640 


<210>  182
<211>  615
<212>  PRT
<213>  Homo Sapiens

<400>  182

Met Ala Val Tyr Val Gly Met Leu Arg Leu Gly Arg Leu Cys Ala Gly 
1               5                   10                  15      


Ser Ser Gly Val Leu Gly Ala Arg Ala Ala Leu Ser Arg Ser Trp Gln 
            20                  25                  30          


Glu Ala Arg Leu Gln Gly Val Arg Phe Leu Ser Ser Arg Glu Val Asp 
        35                  40                  45              


Arg Met Val Ser Thr Pro Ile Gly Gly Leu Ser Tyr Val Gln Gly Cys 
    50                  55                  60                  


Thr Lys Lys His Leu Asn Ser Lys Thr Val Gly Gln Cys Leu Glu Thr 
65                  70                  75                  80  


Thr Ala Gln Arg Val Pro Glu Arg Glu Ala Leu Val Val Leu His Glu 
                85                  90                  95      


Asp Val Arg Leu Thr Phe Ala Gln Leu Lys Glu Glu Val Asp Lys Ala 
            100                 105                 110         


Ala Ser Gly Leu Leu Ser Ile Gly Leu Cys Lys Gly Asp Arg Leu Gly 
        115                 120                 125             


Met Trp Gly Pro Asn Ser Tyr Ala Trp Val Leu Met Gln Leu Ala Thr 
    130                 135                 140                 


Ala Gln Ala Gly Ile Ile Leu Val Ser Val Asn Pro Ala Tyr Gln Ala 
145                 150                 155                 160 


Met Glu Leu Glu Tyr Val Leu Lys Lys Val Gly Cys Lys Ala Leu Val 
                165                 170                 175     


Phe Pro Lys Gln Phe Lys Thr Gln Gln Tyr Tyr Asn Val Leu Lys Gln 
            180                 185                 190         


Ile Cys Pro Glu Val Glu Asn Ala Gln Pro Gly Ala Leu Lys Ser Gln 
        195                 200                 205             


Arg Leu Pro Asp Leu Thr Thr Val Ile Ser Val Asp Ala Pro Leu Pro 
    210                 215                 220                 


Gly Thr Leu Leu Leu Asp Glu Val Val Ala Ala Gly Ser Thr Arg Gln 
225                 230                 235                 240 


His Leu Asp Gln Leu Gln Tyr Asn Gln Gln Phe Leu Ser Cys His Asp 
                245                 250                 255     


Pro Ile Asn Ile Gln Phe Thr Ser Gly Thr Thr Gly Ser Pro Lys Gly 
            260                 265                 270         


Ala Thr Leu Ser His Tyr Asn Ile Val Asn Asn Ser Asn Ile Leu Gly 
        275                 280                 285             


Glu Arg Leu Lys Leu His Glu Lys Thr Pro Glu Gln Leu Arg Met Ile 
    290                 295                 300                 


Leu Pro Asn Pro Leu Tyr His Cys Leu Gly Ser Val Ala Gly Thr Met 
305                 310                 315                 320 


Met Cys Leu Met Tyr Gly Ala Thr Leu Ile Leu Ala Ser Pro Ile Phe 
                325                 330                 335     


Asn Gly Lys Lys Ala Leu Glu Ala Ile Ser Arg Glu Arg Gly Thr Phe 
            340                 345                 350         


Leu Tyr Gly Thr Pro Thr Met Phe Val Asp Ile Leu Asn Gln Pro Asp 
        355                 360                 365             


Phe Ser Ser Tyr Asp Ile Ser Thr Met Cys Gly Gly Val Ile Ala Gly 
    370                 375                 380                 


Ser Pro Ala Pro Pro Glu Leu Ile Arg Ala Ile Ile Asn Lys Ile Asn 
385                 390                 395                 400 


Met Lys Asp Leu Val Val Ala Tyr Gly Thr Thr Glu Asn Ser Pro Val 
                405                 410                 415     


Thr Phe Ala His Phe Pro Glu Asp Thr Val Glu Gln Lys Ala Glu Ser 
            420                 425                 430         


Val Gly Arg Ile Met Pro His Thr Glu Ala Arg Ile Met Asn Met Glu 
        435                 440                 445             


Ala Gly Thr Leu Ala Lys Leu Asn Thr Pro Gly Glu Leu Cys Ile Arg 
    450                 455                 460                 


Gly Tyr Cys Val Met Leu Gly Tyr Trp Gly Glu Pro Gln Lys Thr Glu 
465                 470                 475                 480 


Glu Ala Val Asp Gln Asp Lys Trp Tyr Trp Thr Gly Asp Val Ala Thr 
                485                 490                 495     


Met Asn Glu Gln Gly Phe Cys Lys Ile Val Gly Arg Ser Lys Asp Met 
            500                 505                 510         


Ile Ile Arg Gly Gly Glu Asn Ile Tyr Pro Ala Glu Leu Glu Asp Phe 
        515                 520                 525             


Phe His Thr His Pro Lys Val Gln Glu Val Gln Val Val Gly Val Lys 
    530                 535                 540                 


Asp Asp Arg Met Gly Glu Glu Ile Cys Ala Cys Ile Arg Leu Lys Asp 
545                 550                 555                 560 


Gly Glu Glu Thr Thr Val Glu Glu Ile Lys Ala Phe Cys Lys Gly Lys 
                565                 570                 575     


Ile Ser His Phe Lys Ile Pro Lys Tyr Ile Val Phe Val Thr Asn Tyr 
            580                 585                 590         


Pro Leu Thr Ile Ser Gly Lys Ile Gln Lys Phe Lys Leu Arg Glu Gln 
        595                 600                 605             


Met Glu Arg His Leu Asn Leu 
    610                 615 


<210>  183
<211>  602
<212>  PRT
<213>  Homo Sapiens

<400>  183

Met Ala Val Tyr Val Gly Met Leu Arg Leu Gly Arg Leu Cys Ala Gly 
1               5                   10                  15      


Ser Ser Gly Val Leu Gly Ala Arg Ala Ala Leu Ser Arg Ser Trp Gln 
            20                  25                  30          


Glu Ala Arg Leu Gln Gly Val Arg Phe Leu Ser Ser Arg Glu Val Asp 
        35                  40                  45              


Arg Met Val Ser Thr Pro Ile Gly Gly Leu Ser Tyr Val Gln Gly Cys 
    50                  55                  60                  


Thr Lys Lys His Leu Asn Ser Lys Thr Val Gly Gln Cys Leu Glu Thr 
65                  70                  75                  80  


Thr Ala Gln Arg Val Pro Glu Arg Glu Ala Leu Val Val Leu His Glu 
                85                  90                  95      


Asp Val Arg Leu Thr Phe Ala Gln Leu Lys Glu Glu Val Asp Lys Ala 
            100                 105                 110         


Ala Ser Gly Leu Leu Ser Ile Gly Leu Cys Lys Gly Asp Arg Leu Gly 
        115                 120                 125             


Met Trp Gly Pro Asn Ser Tyr Ala Trp Val Leu Met Gln Leu Ala Thr 
    130                 135                 140                 


Ala Gln Ala Met Glu Leu Glu Tyr Val Leu Lys Lys Val Gly Cys Lys 
145                 150                 155                 160 


Ala Leu Val Phe Pro Lys Gln Phe Lys Thr Gln Gln Tyr Tyr Asn Val 
                165                 170                 175     


Leu Lys Gln Ile Cys Pro Glu Val Glu Asn Ala Gln Pro Gly Ala Leu 
            180                 185                 190         


Lys Ser Gln Arg Leu Pro Asp Leu Thr Thr Val Ile Ser Val Asp Ala 
        195                 200                 205             


Pro Leu Pro Gly Thr Leu Leu Leu Asp Glu Val Val Ala Ala Gly Ser 
    210                 215                 220                 


Thr Arg Gln His Leu Asp Gln Leu Gln Tyr Asn Gln Gln Phe Leu Ser 
225                 230                 235                 240 


Cys His Asp Pro Ile Asn Ile Gln Phe Thr Ser Gly Thr Thr Gly Ser 
                245                 250                 255     


Pro Lys Gly Ala Thr Leu Ser His Tyr Asn Ile Val Asn Asn Ser Asn 
            260                 265                 270         


Ile Leu Gly Glu Arg Leu Lys Leu His Glu Lys Thr Pro Glu Gln Leu 
        275                 280                 285             


Arg Met Ile Leu Pro Asn Pro Leu Tyr His Cys Leu Gly Ser Val Ala 
    290                 295                 300                 


Gly Thr Met Met Cys Leu Met Tyr Gly Ala Thr Leu Ile Leu Ala Ser 
305                 310                 315                 320 


Pro Ile Phe Asn Gly Lys Lys Ala Leu Glu Ala Ile Ser Arg Glu Arg 
                325                 330                 335     


Gly Thr Phe Leu Tyr Gly Thr Pro Thr Met Phe Val Asp Ile Leu Asn 
            340                 345                 350         


Gln Pro Asp Phe Ser Ser Tyr Asp Ile Ser Thr Met Cys Gly Gly Val 
        355                 360                 365             


Ile Ala Gly Ser Pro Ala Pro Pro Glu Leu Ile Arg Ala Ile Ile Asn 
    370                 375                 380                 


Lys Ile Asn Met Lys Asp Leu Val Val Ala Tyr Gly Thr Thr Glu Asn 
385                 390                 395                 400 


Ser Pro Val Thr Phe Ala His Phe Pro Glu Asp Thr Val Glu Gln Lys 
                405                 410                 415     


Ala Glu Ser Val Gly Arg Ile Met Pro His Thr Glu Ala Arg Ile Met 
            420                 425                 430         


Asn Met Glu Ala Gly Thr Leu Ala Lys Leu Asn Thr Pro Gly Glu Leu 
        435                 440                 445             


Cys Ile Arg Gly Tyr Cys Val Met Leu Gly Tyr Trp Gly Glu Pro Gln 
    450                 455                 460                 


Lys Thr Glu Glu Ala Val Asp Gln Asp Lys Trp Tyr Trp Thr Gly Asp 
465                 470                 475                 480 


Val Ala Thr Met Asn Glu Gln Gly Phe Cys Lys Ile Val Gly Arg Ser 
                485                 490                 495     


Lys Asp Met Ile Ile Arg Gly Gly Glu Asn Ile Tyr Pro Ala Glu Leu 
            500                 505                 510         


Glu Asp Phe Phe His Thr His Pro Lys Val Gln Glu Val Gln Val Val 
        515                 520                 525             


Gly Val Lys Asp Asp Arg Met Gly Glu Glu Ile Cys Ala Cys Ile Arg 
    530                 535                 540                 


Leu Lys Asp Gly Glu Glu Thr Thr Val Glu Glu Ile Lys Ala Phe Cys 
545                 550                 555                 560 


Lys Gly Lys Ile Ser His Phe Lys Ile Pro Lys Tyr Ile Val Phe Val 
                565                 570                 575     


Thr Asn Tyr Pro Leu Thr Ile Ser Gly Lys Ile Gln Lys Phe Lys Leu 
            580                 585                 590         


Arg Glu Gln Met Glu Arg His Leu Asn Leu 
        595                 600         


<210>  184
<211>  183
<212>  PRT
<213>  Homo Sapiens

<400>  184

Met Ala Val Tyr Val Gly Met Leu Arg Leu Gly Arg Leu Cys Ala Gly 
1               5                   10                  15      


Ser Ser Gly Val Leu Gly Ala Arg Ala Ala Leu Ser Arg Ser Trp Gln 
            20                  25                  30          


Glu Ala Arg Leu Gln Gly Val Arg Phe Leu Ser Ser Arg Glu Val Asp 
        35                  40                  45              


Arg Met Val Ser Thr Pro Ile Gly Gly Leu Ser Tyr Val Gln Gly Cys 
    50                  55                  60                  


Thr Lys Lys His Leu Asn Ser Lys Thr Val Gly Gln Cys Leu Glu Thr 
65                  70                  75                  80  


Thr Ala Gln Arg Val Pro Glu Arg Glu Ala Leu Val Val Leu His Glu 
                85                  90                  95      


Asp Val Arg Leu Thr Phe Ala Gln Leu Lys Glu Glu Val Asp Lys Ala 
            100                 105                 110         


Ala Ser Gly Leu Leu Ser Ile Gly Leu Cys Lys Gly Val Cys Glu Pro 
        115                 120                 125             


Ser Leu Pro Gly Tyr Gly Thr Gly Val Cys Pro Gln Glu Gly Gly Leu 
    130                 135                 140                 


Gln Gly Pro Cys Val Pro Gln Ala Ile Gln Asp Pro Ala Ile Leu Gln 
145                 150                 155                 160 


Arg Pro Glu Ala Asp Leu Ser Arg Ser Gly Glu Cys Pro Ala Arg Gly 
                165                 170                 175     


Leu Glu Glu Ser Glu Ala Pro 
            180             


<210>  185
<211>  572
<212>  PRT
<213>  Homo Sapiens

<400>  185

Met Ala Val Tyr Val Gly Met Leu Arg Leu Gly Arg Leu Cys Ala Gly 
1               5                   10                  15      


Ser Ser Gly Val Leu Gly Ala Arg Ala Ala Leu Ser Arg Ser Trp Gln 
            20                  25                  30          


Glu Ala Arg Leu Gln Gly Val Arg Phe Leu Ser Ser Arg Glu Val Asp 
        35                  40                  45              


Arg Met Val Ser Thr Pro Ile Gly Gly Leu Ser Tyr Val Gln Gly Cys 
    50                  55                  60                  


Thr Lys Lys His Leu Asn Ser Lys Thr Val Gly Gln Cys Leu Glu Thr 
65                  70                  75                  80  


Thr Ala Gln Arg Val Pro Glu Arg Glu Ala Leu Val Val Leu His Glu 
                85                  90                  95      


Asp Val Arg Leu Thr Phe Ala Gln Leu Lys Glu Glu Val Ser Val Asn 
            100                 105                 110         


Pro Ala Tyr Gln Ala Met Glu Leu Glu Tyr Val Leu Lys Lys Val Gly 
        115                 120                 125             


Cys Lys Ala Leu Val Phe Pro Lys Gln Phe Lys Thr Gln Gln Tyr Tyr 
    130                 135                 140                 


Asn Val Leu Lys Gln Ile Cys Pro Glu Val Glu Asn Ala Gln Pro Gly 
145                 150                 155                 160 


Ala Leu Lys Ser Gln Arg Leu Pro Asp Leu Thr Thr Val Ile Ser Val 
                165                 170                 175     


Asp Ala Pro Leu Pro Gly Thr Leu Leu Leu Asp Glu Val Val Ala Ala 
            180                 185                 190         


Gly Ser Thr Arg Gln His Leu Asp Gln Leu Gln Tyr Asn Gln Gln Phe 
        195                 200                 205             


Leu Ser Cys His Asp Pro Ile Asn Ile Gln Phe Thr Ser Gly Thr Thr 
    210                 215                 220                 


Gly Ser Pro Lys Gly Ala Thr Leu Ser His Tyr Asn Ile Val Asn Asn 
225                 230                 235                 240 


Ser Asn Ile Leu Gly Glu Arg Leu Lys Leu His Glu Lys Thr Pro Glu 
                245                 250                 255     


Gln Leu Arg Met Ile Leu Pro Asn Pro Leu Tyr His Cys Leu Gly Ser 
            260                 265                 270         


Val Ala Gly Thr Met Met Cys Leu Met Tyr Gly Ala Thr Leu Ile Leu 
        275                 280                 285             


Ala Ser Pro Ile Phe Asn Gly Lys Lys Ala Leu Glu Ala Ile Ser Arg 
    290                 295                 300                 


Glu Arg Gly Thr Phe Leu Tyr Gly Thr Pro Thr Met Phe Val Asp Ile 
305                 310                 315                 320 


Leu Asn Gln Pro Asp Phe Ser Ser Tyr Asp Ile Ser Thr Met Cys Gly 
                325                 330                 335     


Gly Val Ile Ala Gly Ser Pro Ala Pro Pro Glu Leu Ile Arg Ala Ile 
            340                 345                 350         


Ile Asn Lys Ile Asn Met Lys Asp Leu Val Val Ala Tyr Gly Thr Thr 
        355                 360                 365             


Glu Asn Ser Pro Val Thr Phe Ala His Phe Pro Glu Asp Thr Val Glu 
    370                 375                 380                 


Gln Lys Ala Glu Ser Val Gly Arg Ile Met Pro His Thr Glu Ala Arg 
385                 390                 395                 400 


Ile Met Asn Met Glu Ala Gly Thr Leu Ala Lys Leu Asn Thr Pro Gly 
                405                 410                 415     


Glu Leu Cys Ile Arg Gly Tyr Cys Val Met Leu Gly Tyr Trp Gly Glu 
            420                 425                 430         


Pro Gln Lys Thr Glu Glu Ala Val Asp Gln Asp Lys Trp Tyr Trp Thr 
        435                 440                 445             


Gly Asp Val Ala Thr Met Asn Glu Gln Gly Phe Cys Lys Ile Val Gly 
    450                 455                 460                 


Arg Ser Lys Asp Met Ile Ile Arg Gly Gly Glu Asn Ile Tyr Pro Ala 
465                 470                 475                 480 


Glu Leu Glu Asp Phe Phe His Thr His Pro Lys Val Gln Glu Val Gln 
                485                 490                 495     


Val Val Gly Val Lys Asp Asp Arg Met Gly Glu Glu Ile Cys Ala Cys 
            500                 505                 510         


Ile Arg Leu Lys Asp Gly Glu Glu Thr Thr Val Glu Glu Ile Lys Ala 
        515                 520                 525             


Phe Cys Lys Gly Lys Ile Ser His Phe Lys Ile Pro Lys Tyr Ile Val 
    530                 535                 540                 


Phe Val Thr Asn Tyr Pro Leu Thr Ile Ser Gly Lys Ile Gln Lys Phe 
545                 550                 555                 560 


Lys Leu Arg Glu Gln Met Glu Arg His Leu Asn Leu 
                565                 570         


<210>  186
<211>  85
<212>  PRT
<213>  Homo Sapiens

<400>  186

Thr Val Pro Pro Ser Ser Trp Pro Leu Pro Ser Ser Met Ala Arg Arg 
1               5                   10                  15      


His Trp Arg Pro Ser Ala Glu Arg Gly Val Ile Ala Gly Ser Pro Ala 
            20                  25                  30          


Pro Pro Glu Leu Ile Arg Ala Ile Ile Asn Lys Ile Asn Met Lys Asp 
        35                  40                  45              


Leu Val Lys Ser Gln Glu Glu Ile Ala Ala Trp Glu Asp Gly Gln Gln 
    50                  55                  60                  


Ser Thr Asp Val Leu Leu Glu Arg Pro Gly Arg Leu Leu Met Glu Pro 
65                  70                  75                  80  


Gln Arg Thr Val Pro 
                85  


<210>  187
<211>  104
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  187

Xaa Gly Lys Lys Ala Leu Glu Ala Ile Ser Arg Glu Arg Gly Thr Phe 
1               5                   10                  15      


Leu Tyr Gly Thr Pro Thr Met Phe Val Asp Ile Leu Asn Gln Pro Asp 
            20                  25                  30          


Phe Ser Ser Tyr Asp Ile Ser Thr Met Cys Gly Gly Val Ile Ala Gly 
        35                  40                  45              


Ser Pro Ala Pro Pro Glu Leu Ile Arg Ala Ile Ile Asn Lys Ile Asn 
    50                  55                  60                  


Met Lys Asp Leu Val Lys Ser Gln Glu Glu Ile Ala Ala Trp Glu Asp 
65                  70                  75                  80  


Gly Gln Gln Ser Thr Asp Val Leu Leu Glu Arg Pro Gly Arg Leu Leu 
                85                  90                  95      


Met Glu Pro Gln Arg Thr Val Pro 
            100                 


<210>  188
<211>  245
<212>  PRT
<213>  Homo Sapiens

<400>  188

Met Ala Ser Thr Ala Leu Leu Ala Leu Cys Ser Thr Gly Ala Phe Ser 
1               5                   10                  15      


Gly Leu Ala Val Glu Ala Gly Ala Gly Val Cys His Ala Thr Pro Ile 
            20                  25                  30          


Tyr Ala Gly His Ser Trp His Gln Ala Thr Phe Arg Leu Asn Val Ala 
        35                  40                  45              


Gly Ser Thr Leu Ser Arg Tyr Leu Arg Asp Leu Leu Val Ala Ala Asn 
    50                  55                  60                  


Pro Asp Leu Leu Gln Gln Ala Leu Pro Arg Lys Ala Ile Thr His Leu 
65                  70                  75                  80  


Lys Lys Arg Ser Cys Tyr Val Ser Leu Asp Phe Glu Gly Asp Leu Arg 
                85                  90                  95      


Asp Pro Ala Arg His His Pro Ala Ser Phe Ser Val Gly Asn Gly Cys 
            100                 105                 110         


Cys Val Cys Leu Ser Ser Glu Arg Phe Arg Cys Pro Glu Pro Ile Phe 
        115                 120                 125             


Gln Pro Gly Leu Leu Gly Gln Ala Glu Gln Gly Leu Pro Ala Leu Ala 
    130                 135                 140                 


Phe Arg Ala Leu Gln Lys Met Pro Lys Thr Leu Arg Thr Arg Leu Ala 
145                 150                 155                 160 


Asp Thr Val Val Leu Ala Gly Gly Ser Thr Leu Phe Pro Gly Phe Ala 
                165                 170                 175     


Glu Arg Leu Asp Lys Glu Leu Glu Ala Gln Cys Arg Arg His Gly Tyr 
            180                 185                 190         


Ala Ala Leu Arg Pro His Leu Val Ala Lys His Gly Arg Gly Met Ala 
        195                 200                 205             


Val Trp Thr Gly Gly Ser Met Val Ala Ser Leu His Ser Phe Gln Arg 
    210                 215                 220                 


Arg Trp Ile Thr Arg Ala Met Tyr Gln Glu Cys Gly Ser Arg Leu Leu 
225                 230                 235                 240 


Tyr Asp Val Phe Asn 
                245 


<210>  189
<211>  21
<212>  PRT
<213>  Homo Sapiens

<400>  189

Met Val Asp Gly Val Met Ile Leu Pro Val Leu Ile Met Ile Ala Leu 
1               5                   10                  15      


Pro Ser Pro Ser Met 
            20      


<210>  190
<211>  71
<212>  PRT
<213>  Homo Sapiens

<400>  190

Met Val Asp Gly Val Met Ile Leu Pro Val Leu Ile Met Ile Ala Leu 
1               5                   10                  15      


Pro Ser Pro Ser Met Glu Asp Glu Lys Pro Lys Val Asn Pro Lys Leu 
            20                  25                  30          


Tyr Met Cys Val Cys Glu Gly Leu Ser Cys Gly Asn Glu Asp His Cys 
        35                  40                  45              


Glu Gly Gln Gln Cys Phe Ser Ser Leu Ser Ile Asn Asp Gly Phe His 
    50                  55                  60                  


Val Tyr Gln Lys Gly Cys Phe 
65                  70      


<210>  191
<211>  73
<212>  PRT
<213>  Homo Sapiens

<400>  191

Met Val Asp Gly Val Met Ile Leu Pro Val Leu Ile Met Ile Ala Leu 
1               5                   10                  15      


Pro Ser Pro Ser Met Glu Asp Glu Lys Pro Lys Val Asn Pro Lys Leu 
            20                  25                  30          


Tyr Met Cys Val Cys Glu Gly Leu Ser Cys Gly Asn Glu Asp His Cys 
        35                  40                  45              


Glu Gly Gln Gln Cys Phe Ser Ser Leu Ser Ile Asn Asp Gly Phe His 
    50                  55                  60                  


Val Tyr Gln Lys Gly Cys Phe Gln Val 
65                  70              


<210>  192
<211>  87
<212>  PRT
<213>  Homo Sapiens

<400>  192

Met Val Asp Gly Val Met Ile Leu Pro Val Leu Ile Met Ile Ala Leu 
1               5                   10                  15      


Pro Ser Pro Ser Met Glu Asp Glu Lys Pro Lys Val Asn Pro Lys Leu 
            20                  25                  30          


Tyr Met Cys Val Cys Glu Gly Leu Ser Cys Gly Asn Glu Asp His Cys 
        35                  40                  45              


Glu Gly Gln Gln Cys Phe Ser Ser Leu Ser Ile Asn Asp Gly Phe His 
    50                  55                  60                  


Val Tyr Gln Lys Gly Cys Phe Gln Val Tyr Glu Gln Gly Lys Met Thr 
65                  70                  75                  80  


Cys Lys Thr Pro Pro Ser Pro 
                85          


<210>  193
<211>  87
<212>  PRT
<213>  Homo Sapiens

<400>  193

Met Val Asp Gly Val Met Ile Leu Pro Val Leu Ile Met Ile Ala Leu 
1               5                   10                  15      


Pro Ser Pro Ser Met Glu Asp Glu Lys Pro Lys Val Asn Pro Lys Leu 
            20                  25                  30          


Tyr Met Cys Val Cys Glu Gly Leu Ser Cys Gly Asn Glu Asp His Cys 
        35                  40                  45              


Glu Gly Gln Gln Cys Phe Ser Ser Leu Ser Ile Asn Asp Gly Phe His 
    50                  55                  60                  


Val Tyr Gln Lys Gly Cys Phe Gln Val Tyr Glu Gln Gly Lys Met Thr 
65                  70                  75                  80  


Cys Lys Thr Pro Pro Ser Pro 
                85          


<210>  194
<211>  509
<212>  PRT
<213>  Homo Sapiens

<400>  194

Met Val Asp Gly Val Met Ile Leu Pro Val Leu Ile Met Ile Ala Leu 
1               5                   10                  15      


Pro Ser Pro Ser Met Glu Asp Glu Lys Pro Lys Val Asn Pro Lys Leu 
            20                  25                  30          


Tyr Met Cys Val Cys Glu Gly Leu Ser Cys Gly Asn Glu Asp His Cys 
        35                  40                  45              


Glu Gly Gln Gln Cys Phe Ser Ser Leu Ser Ile Asn Asp Gly Phe His 
    50                  55                  60                  


Val Tyr Gln Lys Gly Cys Phe Gln Val Tyr Glu Gln Gly Lys Met Thr 
65                  70                  75                  80  


Cys Lys Thr Pro Pro Ser Pro Gly Gln Ala Val Glu Cys Cys Gln Gly 
                85                  90                  95      


Asp Trp Cys Asn Arg Asn Ile Thr Ala Gln Leu Pro Thr Lys Gly Lys 
            100                 105                 110         


Ser Phe Pro Gly Thr Gln Asn Phe His Leu Glu Val Gly Leu Ile Ile 
        115                 120                 125             


Leu Ser Val Val Phe Ala Val Cys Leu Leu Ala Cys Leu Leu Gly Val 
    130                 135                 140                 


Ala Leu Arg Lys Phe Lys Arg Arg Asn Gln Glu Arg Leu Asn Pro Arg 
145                 150                 155                 160 


Asp Val Glu Tyr Gly Thr Ile Glu Gly Leu Ile Thr Thr Asn Val Gly 
                165                 170                 175     


Asp Ser Thr Leu Ala Asp Leu Leu Asp His Ser Cys Thr Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Leu Pro Phe Leu Val Gln Arg Thr Val Ala Arg Gln Ile 
        195                 200                 205             


Thr Leu Leu Glu Cys Val Gly Lys Gly Arg Tyr Gly Glu Val Trp Arg 
    210                 215                 220                 


Gly Ser Trp Gln Gly Glu Asn Val Ala Val Lys Ile Phe Ser Ser Arg 
225                 230                 235                 240 


Asp Glu Lys Ser Trp Phe Arg Glu Thr Glu Leu Tyr Asn Thr Val Met 
                245                 250                 255     


Leu Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ser Asp Met Thr Ser 
            260                 265                 270         


Arg His Ser Ser Thr Gln Leu Trp Leu Ile Thr His Tyr His Glu Met 
        275                 280                 285             


Gly Ser Leu Tyr Asp Tyr Leu Gln Leu Thr Thr Leu Asp Thr Val Ser 
    290                 295                 300                 


Cys Leu Arg Ile Val Leu Ser Ile Ala Ser Gly Leu Ala His Leu His 
305                 310                 315                 320 


Ile Glu Ile Phe Gly Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp 
                325                 330                 335     


Leu Lys Ser Lys Asn Ile Leu Val Lys Lys Asn Gly Gln Cys Cys Ile 
            340                 345                 350         


Ala Asp Leu Gly Leu Ala Val Met His Ser Gln Ser Thr Asn Gln Leu 
        355                 360                 365             


Asp Val Gly Asn Asn Pro Arg Val Gly Thr Lys Arg Tyr Met Ala Pro 
    370                 375                 380                 


Glu Val Leu Asp Glu Thr Ile Gln Val Asp Cys Phe Asp Ser Tyr Lys 
385                 390                 395                 400 


Arg Val Asp Ile Trp Ala Phe Gly Leu Val Leu Trp Glu Val Ala Arg 
                405                 410                 415     


Arg Met Val Ser Asn Gly Ile Val Glu Asp Tyr Lys Pro Pro Phe Tyr 
            420                 425                 430         


Asp Val Val Pro Asn Asp Pro Ser Phe Glu Asp Met Arg Lys Val Val 
        435                 440                 445             


Cys Val Asp Gln Gln Arg Pro Asn Ile Pro Asn Arg Trp Phe Ser Asp 
    450                 455                 460                 


Pro Thr Leu Thr Ser Leu Ala Lys Leu Met Lys Glu Cys Trp Tyr Gln 
465                 470                 475                 480 


Asn Pro Ser Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Thr 
                485                 490                 495     


Lys Ile Asp Asn Ser Leu Asp Lys Leu Lys Thr Asp Cys 
            500                 505                 


<210>  195
<211>  509
<212>  PRT
<213>  Homo Sapiens

<400>  195

Met Val Asp Gly Val Met Ile Leu Pro Val Leu Ile Met Ile Ala Leu 
1               5                   10                  15      


Pro Ser Pro Ser Met Glu Asp Glu Lys Pro Lys Val Asn Pro Lys Leu 
            20                  25                  30          


Tyr Met Cys Val Cys Glu Gly Leu Ser Cys Gly Asn Glu Asp His Cys 
        35                  40                  45              


Glu Gly Gln Gln Cys Phe Ser Ser Leu Ser Ile Asn Asp Gly Phe His 
    50                  55                  60                  


Val Tyr Gln Lys Gly Cys Phe Gln Val Tyr Glu Gln Gly Lys Met Thr 
65                  70                  75                  80  


Cys Lys Thr Pro Pro Ser Pro Gly Gln Ala Val Glu Cys Cys Gln Gly 
                85                  90                  95      


Asp Trp Cys Asn Arg Asn Ile Thr Ala Gln Leu Pro Thr Lys Gly Lys 
            100                 105                 110         


Ser Phe Pro Gly Thr Gln Asn Phe His Leu Glu Val Gly Leu Ile Ile 
        115                 120                 125             


Leu Ser Val Val Phe Ala Val Cys Leu Leu Ala Cys Leu Leu Gly Val 
    130                 135                 140                 


Ala Leu Arg Lys Phe Lys Arg Arg Asn Gln Glu Arg Leu Asn Pro Arg 
145                 150                 155                 160 


Asp Val Glu Tyr Gly Thr Ile Glu Gly Leu Ile Thr Thr Asn Val Gly 
                165                 170                 175     


Asp Ser Thr Leu Ala Asp Leu Leu Asp His Ser Cys Thr Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Leu Pro Phe Leu Val Gln Arg Thr Val Ala Arg Gln Ile 
        195                 200                 205             


Thr Leu Leu Glu Cys Val Gly Lys Gly Arg Tyr Gly Glu Val Trp Arg 
    210                 215                 220                 


Gly Ser Trp Gln Gly Glu Asn Val Ala Val Lys Ile Phe Ser Ser Arg 
225                 230                 235                 240 


Asp Glu Lys Ser Trp Phe Arg Glu Thr Glu Leu Tyr Asn Thr Val Met 
                245                 250                 255     


Leu Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ser Asp Met Thr Ser 
            260                 265                 270         


Arg His Ser Ser Thr Gln Leu Trp Leu Ile Thr His Tyr His Glu Met 
        275                 280                 285             


Gly Ser Leu Tyr Asp Tyr Leu Gln Leu Thr Thr Leu Asp Thr Val Ser 
    290                 295                 300                 


Cys Leu Arg Ile Val Leu Ser Ile Ala Ser Gly Leu Ala His Leu His 
305                 310                 315                 320 


Ile Glu Ile Phe Gly Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp 
                325                 330                 335     


Leu Lys Ser Lys Asn Ile Leu Val Lys Lys Asn Gly Gln Cys Cys Ile 
            340                 345                 350         


Ala Asp Leu Gly Leu Ala Val Met His Ser Gln Ser Thr Asn Gln Leu 
        355                 360                 365             


Asp Val Gly Asn Asn Pro Arg Val Gly Thr Lys Arg Tyr Met Ala Pro 
    370                 375                 380                 


Glu Val Leu Asp Glu Thr Ile Gln Val Asp Cys Phe Asp Ser Tyr Lys 
385                 390                 395                 400 


Arg Val Asp Ile Trp Ala Phe Gly Leu Val Leu Trp Glu Val Ala Arg 
                405                 410                 415     


Arg Met Val Ser Asn Gly Ile Val Glu Asp Tyr Lys Pro Pro Phe Tyr 
            420                 425                 430         


Asp Val Val Pro Asn Asp Pro Ser Phe Glu Asp Met Arg Lys Val Val 
        435                 440                 445             


Cys Val Asp Gln Gln Arg Pro Asn Ile Pro Asn Arg Trp Phe Ser Asp 
    450                 455                 460                 


Pro Thr Leu Thr Ser Leu Ala Lys Leu Met Lys Glu Cys Trp Tyr Gln 
465                 470                 475                 480 


Asn Pro Ser Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Thr 
                485                 490                 495     


Lys Ile Asp Asn Ser Leu Asp Lys Leu Lys Thr Asp Cys 
            500                 505                 


<210>  196
<211>  509
<212>  PRT
<213>  Homo Sapiens

<400>  196

Met Val Asp Gly Val Met Ile Leu Pro Val Leu Ile Met Ile Ala Leu 
1               5                   10                  15      


Pro Ser Pro Ser Met Glu Asp Glu Lys Pro Lys Val Asn Pro Lys Leu 
            20                  25                  30          


Tyr Met Cys Val Cys Glu Gly Leu Ser Cys Gly Asn Glu Asp His Cys 
        35                  40                  45              


Glu Gly Gln Gln Cys Phe Ser Ser Leu Ser Ile Asn Asp Gly Phe His 
    50                  55                  60                  


Val Tyr Gln Lys Gly Cys Phe Gln Val Tyr Glu Gln Gly Lys Met Thr 
65                  70                  75                  80  


Cys Lys Thr Pro Pro Ser Pro Gly Gln Ala Val Glu Cys Cys Gln Gly 
                85                  90                  95      


Asp Trp Cys Asn Arg Asn Ile Thr Ala Gln Leu Pro Thr Lys Gly Lys 
            100                 105                 110         


Ser Phe Pro Gly Thr Gln Asn Phe His Leu Glu Val Gly Leu Ile Ile 
        115                 120                 125             


Leu Ser Val Val Phe Ala Val Cys Leu Leu Ala Cys Leu Leu Gly Val 
    130                 135                 140                 


Ala Leu Arg Lys Phe Lys Arg Arg Asn Gln Glu Arg Leu Asn Pro Arg 
145                 150                 155                 160 


Asp Val Glu Tyr Gly Thr Ile Glu Gly Leu Ile Thr Thr Asn Val Gly 
                165                 170                 175     


Asp Ser Thr Leu Ala Asp Leu Leu Asp His Ser Cys Thr Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Leu Pro Phe Leu Val Gln Arg Thr Val Ala Arg Gln Ile 
        195                 200                 205             


Thr Leu Leu Glu Cys Val Gly Lys Gly Arg Tyr Gly Glu Val Trp Arg 
    210                 215                 220                 


Gly Ser Trp Gln Gly Glu Asn Val Ala Val Lys Ile Phe Ser Ser Arg 
225                 230                 235                 240 


Asp Glu Lys Ser Trp Phe Arg Glu Thr Glu Leu Tyr Asn Thr Val Met 
                245                 250                 255     


Leu Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ser Asp Met Thr Ser 
            260                 265                 270         


Arg His Ser Ser Thr Gln Leu Trp Leu Ile Thr His Tyr His Glu Met 
        275                 280                 285             


Gly Ser Leu Tyr Asp Tyr Leu Gln Leu Thr Thr Leu Asp Thr Val Ser 
    290                 295                 300                 


Cys Leu Arg Ile Val Leu Ser Ile Ala Ser Gly Leu Ala His Leu His 
305                 310                 315                 320 


Ile Glu Ile Phe Gly Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp 
                325                 330                 335     


Leu Lys Ser Lys Asn Ile Leu Val Lys Lys Asn Gly Gln Cys Cys Ile 
            340                 345                 350         


Ala Asp Leu Gly Leu Ala Val Met His Ser Gln Ser Thr Asn Gln Leu 
        355                 360                 365             


Asp Val Gly Asn Asn Pro Arg Val Gly Thr Lys Arg Tyr Met Ala Pro 
    370                 375                 380                 


Glu Val Leu Asp Glu Thr Ile Gln Val Asp Cys Phe Asp Ser Tyr Lys 
385                 390                 395                 400 


Arg Val Asp Ile Trp Ala Phe Gly Leu Val Leu Trp Glu Val Ala Arg 
                405                 410                 415     


Arg Met Val Ser Asn Gly Ile Val Glu Asp Tyr Lys Pro Pro Phe Tyr 
            420                 425                 430         


Asp Val Val Pro Asn Asp Pro Ser Phe Glu Asp Met Arg Lys Val Val 
        435                 440                 445             


Cys Val Asp Gln Gln Arg Pro Asn Ile Pro Asn Arg Trp Phe Ser Asp 
    450                 455                 460                 


Pro Thr Leu Thr Ser Leu Ala Lys Leu Met Lys Glu Cys Trp Tyr Gln 
465                 470                 475                 480 


Asn Pro Ser Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Thr 
                485                 490                 495     


Lys Ile Asp Asn Ser Leu Asp Lys Leu Lys Thr Asp Cys 
            500                 505                 


<210>  197
<211>  509
<212>  PRT
<213>  Homo Sapiens

<400>  197

Met Val Asp Gly Val Met Ile Leu Pro Val Leu Ile Met Ile Ala Leu 
1               5                   10                  15      


Pro Ser Pro Ser Met Glu Asp Glu Lys Pro Lys Val Asn Pro Lys Leu 
            20                  25                  30          


Tyr Met Cys Val Cys Glu Gly Leu Ser Cys Gly Asn Glu Asp His Cys 
        35                  40                  45              


Glu Gly Gln Gln Cys Phe Ser Ser Leu Ser Ile Asn Asp Gly Phe His 
    50                  55                  60                  


Val Tyr Gln Lys Gly Cys Phe Gln Val Tyr Glu Gln Gly Lys Met Thr 
65                  70                  75                  80  


Cys Lys Thr Pro Pro Ser Pro Gly Gln Ala Val Glu Cys Cys Gln Gly 
                85                  90                  95      


Asp Trp Cys Asn Arg Asn Ile Thr Ala Gln Leu Pro Thr Lys Gly Lys 
            100                 105                 110         


Ser Phe Pro Gly Thr Gln Asn Phe His Leu Glu Val Gly Leu Ile Ile 
        115                 120                 125             


Leu Ser Val Val Phe Ala Val Cys Leu Leu Ala Cys Leu Leu Gly Val 
    130                 135                 140                 


Ala Leu Arg Lys Phe Lys Arg Arg Asn Gln Glu Arg Leu Asn Pro Arg 
145                 150                 155                 160 


Asp Val Glu Tyr Gly Thr Ile Glu Gly Leu Ile Thr Thr Asn Val Gly 
                165                 170                 175     


Asp Ser Thr Leu Ala Asp Leu Leu Asp His Ser Cys Thr Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Leu Pro Phe Leu Val Gln Arg Thr Val Ala Arg Gln Ile 
        195                 200                 205             


Thr Leu Leu Glu Cys Val Gly Lys Gly Arg Tyr Gly Glu Val Trp Arg 
    210                 215                 220                 


Gly Ser Trp Gln Gly Glu Asn Val Ala Val Lys Ile Phe Ser Ser Arg 
225                 230                 235                 240 


Asp Glu Lys Ser Trp Phe Arg Glu Thr Glu Leu Tyr Asn Thr Val Met 
                245                 250                 255     


Leu Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ser Asp Met Thr Ser 
            260                 265                 270         


Arg His Ser Ser Thr Gln Leu Trp Leu Ile Thr His Tyr His Glu Met 
        275                 280                 285             


Gly Ser Leu Tyr Asp Tyr Leu Gln Leu Thr Thr Leu Asp Thr Val Ser 
    290                 295                 300                 


Cys Leu Arg Ile Val Leu Ser Ile Ala Ser Gly Leu Ala His Leu His 
305                 310                 315                 320 


Ile Glu Ile Phe Gly Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp 
                325                 330                 335     


Leu Lys Ser Lys Asn Ile Leu Val Lys Lys Asn Gly Gln Cys Cys Ile 
            340                 345                 350         


Ala Asp Leu Gly Leu Ala Val Met His Ser Gln Ser Thr Asn Gln Leu 
        355                 360                 365             


Asp Val Gly Asn Asn Pro Arg Val Gly Thr Lys Arg Tyr Met Ala Pro 
    370                 375                 380                 


Glu Val Leu Asp Glu Thr Ile Gln Val Asp Cys Phe Asp Ser Tyr Lys 
385                 390                 395                 400 


Arg Val Asp Ile Trp Ala Phe Gly Leu Val Leu Trp Glu Val Ala Arg 
                405                 410                 415     


Arg Met Val Ser Asn Gly Ile Val Glu Asp Tyr Lys Pro Pro Phe Tyr 
            420                 425                 430         


Asp Val Val Pro Asn Asp Pro Ser Phe Glu Asp Met Arg Lys Val Val 
        435                 440                 445             


Cys Val Asp Gln Gln Arg Pro Asn Ile Pro Asn Arg Trp Phe Ser Asp 
    450                 455                 460                 


Pro Thr Leu Thr Ser Leu Ala Lys Leu Met Lys Glu Cys Trp Tyr Gln 
465                 470                 475                 480 


Asn Pro Ser Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Thr 
                485                 490                 495     


Lys Ile Asp Asn Ser Leu Asp Lys Leu Lys Thr Asp Cys 
            500                 505                 


<210>  198
<211>  443
<212>  PRT
<213>  Homo Sapiens

<400>  198

Met Leu Thr Asn Gly Lys Glu Gln Val Ile Lys Ser Cys Val Ser Leu 
1               5                   10                  15      


Pro Glu Leu Asn Ala Gln Val Phe Cys His Ser Ser Asn Asn Val Thr 
            20                  25                  30          


Lys Thr Glu Cys Cys Phe Thr Asp Phe Cys Asn Asn Ile Thr Leu His 
        35                  40                  45              


Leu Pro Thr Ala Ser Pro Asn Ala Pro Lys Leu Gly Pro Met Glu Leu 
    50                  55                  60                  


Ala Ile Ile Ile Thr Val Pro Val Cys Leu Leu Ser Ile Ala Ala Met 
65                  70                  75                  80  


Leu Thr Val Trp Ala Cys Gln Gly Arg Gln Cys Ser Tyr Arg Lys Lys 
                85                  90                  95      


Lys Arg Pro Asn Val Glu Glu Pro Leu Ser Glu Cys Asn Leu Val Asn 
            100                 105                 110         


Ala Gly Lys Thr Leu Lys Asp Leu Ile Tyr Asp Val Thr Ala Ser Gly 
        115                 120                 125             


Ser Gly Ser Gly Leu Pro Leu Leu Val Gln Arg Thr Ile Ala Arg Thr 
    130                 135                 140                 


Ile Val Leu Gln Glu Ile Val Gly Lys Gly Arg Phe Gly Glu Val Trp 
145                 150                 155                 160 


His Gly Arg Trp Cys Gly Glu Asp Val Ala Val Lys Ile Phe Ser Ser 
                165                 170                 175     


Arg Asp Glu Arg Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln Thr Val 
            180                 185                 190         


Met Leu Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp Asn Lys 
        195                 200                 205             


Asp Asn Gly Thr Trp Thr Gln Leu Trp Leu Val Ser Glu Tyr His Glu 
    210                 215                 220                 


Gln Gly Ser Leu Tyr Asp Tyr Leu Asn Arg Asn Ile Val Thr Val Ala 
225                 230                 235                 240 


Gly Met Ile Lys Leu Ala Leu Ser Ile Ala Ser Gly Leu Ala His Leu 
                245                 250                 255     


His Met Glu Ile Val Gly Thr Gln Gly Lys Pro Ala Ile Ala His Arg 
            260                 265                 270         


Asp Ile Lys Ser Lys Asn Ile Leu Val Lys Lys Cys Glu Thr Cys Ala 
        275                 280                 285             


Ile Ala Asp Leu Gly Leu Ala Val Lys His Asp Ser Ile Leu Asn Thr 
    290                 295                 300                 


Ile Asp Ile Pro Gln Asn Pro Lys Val Gly Thr Lys Arg Tyr Met Ala 
305                 310                 315                 320 


Pro Glu Met Leu Asp Asp Thr Met Asn Val Asn Ile Phe Glu Ser Phe 
                325                 330                 335     


Lys Arg Ala Asp Ile Tyr Ser Val Gly Leu Val Tyr Trp Glu Ile Ala 
            340                 345                 350         


Arg Arg Cys Ser Val Gly Gly Ile Val Glu Glu Tyr Gln Leu Pro Tyr 
        355                 360                 365             


Tyr Asp Met Val Pro Ser Asp Pro Ser Ile Glu Glu Met Arg Lys Val 
    370                 375                 380                 


Val Cys Asp Gln Lys Phe Arg Pro Ser Ile Pro Asn Gln Trp Gln Ser 
385                 390                 395                 400 


Cys Glu Ala Leu Arg Val Met Gly Arg Ile Met Arg Glu Cys Trp Tyr 
                405                 410                 415     


Ala Asn Gly Ala Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Ile 
            420                 425                 430         


Ser Gln Leu Cys Val Lys Glu Asp Cys Lys Ala 
        435                 440             


<210>  199
<211>  493
<212>  PRT
<213>  Homo Sapiens

<400>  199

Met Thr Arg Ala Leu Cys Ser Ala Leu Arg Gln Ala Leu Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Ala Glu Leu Ser Pro Gly Leu Lys Cys Val Cys Leu Leu 
            20                  25                  30          


Cys Asp Ser Ser Asn Phe Thr Cys Gln Thr Glu Gly Ala Cys Trp Ala 
        35                  40                  45              


Ser Val Met Leu Thr Asn Gly Lys Glu Gln Val Ile Lys Ser Cys Val 
    50                  55                  60                  


Ser Leu Pro Glu Leu Asn Ala Gln Val Phe Cys His Ser Ser Asn Asn 
65                  70                  75                  80  


Val Thr Lys Thr Glu Cys Cys Phe Thr Asp Phe Cys Asn Asn Ile Thr 
                85                  90                  95      


Leu His Leu Pro Thr Ala Ser Pro Asn Ala Pro Lys Leu Gly Pro Met 
            100                 105                 110         


Glu Leu Ala Ile Ile Ile Thr Val Pro Val Cys Leu Leu Ser Ile Ala 
        115                 120                 125             


Ala Met Leu Thr Val Trp Ala Cys Gln Gly Arg Gln Cys Ser Tyr Arg 
    130                 135                 140                 


Lys Lys Lys Arg Pro Asn Val Glu Glu Pro Leu Ser Glu Cys Asn Leu 
145                 150                 155                 160 


Val Asn Ala Gly Lys Thr Leu Lys Asp Leu Ile Tyr Asp Val Thr Ala 
                165                 170                 175     


Ser Gly Ser Gly Ser Gly Leu Pro Leu Leu Val Gln Arg Thr Ile Ala 
            180                 185                 190         


Arg Thr Ile Val Leu Gln Glu Ile Val Gly Lys Gly Arg Phe Gly Glu 
        195                 200                 205             


Val Trp His Gly Arg Trp Cys Gly Glu Asp Val Ala Val Lys Ile Phe 
    210                 215                 220                 


Ser Ser Arg Asp Glu Arg Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln 
225                 230                 235                 240 


Thr Val Met Leu Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp 
                245                 250                 255     


Asn Lys Asp Asn Gly Thr Trp Thr Gln Leu Trp Leu Val Ser Glu Tyr 
            260                 265                 270         


His Glu Gln Gly Ser Leu Tyr Asp Tyr Leu Asn Arg Asn Ile Val Thr 
        275                 280                 285             


Val Ala Gly Met Ile Lys Leu Ala Leu Ser Ile Ala Ser Gly Leu Ala 
    290                 295                 300                 


His Leu His Met Glu Ile Val Gly Thr Gln Gly Lys Pro Ala Ile Ala 
305                 310                 315                 320 


His Arg Asp Ile Lys Ser Lys Asn Ile Leu Val Lys Lys Cys Glu Thr 
                325                 330                 335     


Cys Ala Ile Ala Asp Leu Gly Leu Ala Val Lys His Asp Ser Ile Leu 
            340                 345                 350         


Asn Thr Ile Asp Ile Pro Gln Asn Pro Lys Val Gly Thr Lys Arg Tyr 
        355                 360                 365             


Met Ala Pro Glu Met Leu Asp Asp Thr Met Asn Val Asn Ile Phe Glu 
    370                 375                 380                 


Ser Phe Lys Arg Ala Asp Ile Tyr Ser Val Gly Leu Val Tyr Trp Glu 
385                 390                 395                 400 


Ile Ala Arg Arg Cys Ser Val Gly Gly Ile Val Glu Glu Tyr Gln Leu 
                405                 410                 415     


Pro Tyr Tyr Asp Met Val Pro Ser Asp Pro Ser Ile Glu Glu Met Arg 
            420                 425                 430         


Lys Val Val Cys Asp Gln Lys Phe Arg Pro Ser Ile Pro Asn Gln Trp 
        435                 440                 445             


Gln Ser Cys Glu Ala Leu Arg Val Met Gly Arg Ile Met Arg Glu Cys 
    450                 455                 460                 


Trp Tyr Ala Asn Gly Ala Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys 
465                 470                 475                 480 


Thr Ile Ser Gln Leu Cys Val Lys Glu Asp Cys Lys Ala 
                485                 490             


<210>  200
<211>  336
<212>  PRT
<213>  Homo Sapiens

<400>  200

Met Thr Arg Ala Leu Cys Ser Ala Leu Arg Gln Ala Leu Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Ala Glu Leu Ser Pro Gly Leu Lys Cys Val Cys Leu Leu 
            20                  25                  30          


Cys Asp Ser Ser Asn Phe Thr Cys Gln Thr Glu Gly Ala Cys Trp Ala 
        35                  40                  45              


Ser Val Met Leu Thr Asn Gly Lys Glu Gln Val Ile Lys Ser Cys Val 
    50                  55                  60                  


Ser Leu Pro Glu Leu Asn Ala Gln Val Phe Cys His Ser Ser Asn Asn 
65                  70                  75                  80  


Val Thr Lys Thr Glu Cys Cys Phe Thr Asp Phe Cys Asn Asn Ile Thr 
                85                  90                  95      


Leu His Leu Pro Thr Asp Asn Gly Thr Trp Thr Gln Leu Trp Leu Val 
            100                 105                 110         


Ser Glu Tyr His Glu Gln Gly Ser Leu Tyr Asp Tyr Leu Asn Arg Asn 
        115                 120                 125             


Ile Val Thr Val Ala Gly Met Ile Lys Leu Ala Leu Ser Ile Ala Ser 
    130                 135                 140                 


Gly Leu Ala His Leu His Met Glu Ile Val Gly Thr Gln Gly Lys Pro 
145                 150                 155                 160 


Ala Ile Ala His Arg Asp Ile Lys Ser Lys Asn Ile Leu Val Lys Lys 
                165                 170                 175     


Cys Glu Thr Cys Ala Ile Ala Asp Leu Gly Leu Ala Val Lys His Asp 
            180                 185                 190         


Ser Ile Leu Asn Thr Ile Asp Ile Pro Gln Asn Pro Lys Val Gly Thr 
        195                 200                 205             


Lys Arg Tyr Met Ala Pro Glu Met Leu Asp Asp Thr Met Asn Val Asn 
    210                 215                 220                 


Ile Phe Glu Ser Phe Lys Arg Ala Asp Ile Tyr Ser Val Gly Leu Val 
225                 230                 235                 240 


Tyr Trp Glu Ile Ala Arg Arg Cys Ser Val Gly Gly Ile Val Glu Glu 
                245                 250                 255     


Tyr Gln Leu Pro Tyr Tyr Asp Met Val Pro Ser Asp Pro Ser Ile Glu 
            260                 265                 270         


Glu Met Arg Lys Val Val Cys Asp Gln Lys Phe Arg Pro Ser Ile Pro 
        275                 280                 285             


Asn Gln Trp Gln Ser Cys Glu Ala Leu Arg Val Met Gly Arg Ile Met 
    290                 295                 300                 


Arg Glu Cys Trp Tyr Ala Asn Gly Ala Ala Arg Leu Thr Ala Leu Arg 
305                 310                 315                 320 


Ile Lys Lys Thr Ile Ser Gln Leu Cys Val Lys Glu Asp Cys Lys Ala 
                325                 330                 335     


<210>  201
<211>  413
<212>  PRT
<213>  Homo Sapiens

<400>  201

Met Thr Arg Ala Leu Cys Ser Ala Leu Arg Gln Ala Leu Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Ala Glu Leu Ser Pro Gly Leu Lys Cys Val Cys Leu Leu 
            20                  25                  30          


Cys Asp Ser Ser Asn Phe Thr Cys Gln Thr Glu Gly Ala Cys Trp Ala 
        35                  40                  45              


Ser Val Met Leu Thr Asn Gly Lys Glu Gln Val Ile Lys Ser Cys Val 
    50                  55                  60                  


Ser Leu Pro Glu Leu Asn Ala Gln Val Phe Cys His Ser Ser Asn Asn 
65                  70                  75                  80  


Val Thr Lys Thr Glu Cys Cys Phe Thr Asp Phe Cys Asn Asn Ile Thr 
                85                  90                  95      


Leu His Leu Pro Thr Gly Leu Pro Leu Leu Val Gln Arg Thr Ile Ala 
            100                 105                 110         


Arg Thr Ile Val Leu Gln Glu Ile Val Gly Lys Gly Arg Phe Gly Glu 
        115                 120                 125             


Val Trp His Gly Arg Trp Cys Gly Glu Asp Val Ala Val Lys Ile Phe 
    130                 135                 140                 


Ser Ser Arg Asp Glu Arg Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln 
145                 150                 155                 160 


Thr Val Met Leu Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp 
                165                 170                 175     


Asn Lys Asp Asn Gly Thr Trp Thr Gln Leu Trp Leu Val Ser Glu Tyr 
            180                 185                 190         


His Glu Gln Gly Ser Leu Tyr Asp Tyr Leu Asn Arg Asn Ile Val Thr 
        195                 200                 205             


Val Ala Gly Met Ile Lys Leu Ala Leu Ser Ile Ala Ser Gly Leu Ala 
    210                 215                 220                 


His Leu His Met Glu Ile Val Gly Thr Gln Gly Lys Pro Ala Ile Ala 
225                 230                 235                 240 


His Arg Asp Ile Lys Ser Lys Asn Ile Leu Val Lys Lys Cys Glu Thr 
                245                 250                 255     


Cys Ala Ile Ala Asp Leu Gly Leu Ala Val Lys His Asp Ser Ile Leu 
            260                 265                 270         


Asn Thr Ile Asp Ile Pro Gln Asn Pro Lys Val Gly Thr Lys Arg Tyr 
        275                 280                 285             


Met Ala Pro Glu Met Leu Asp Asp Thr Met Asn Val Asn Ile Phe Glu 
    290                 295                 300                 


Ser Phe Lys Arg Ala Asp Ile Tyr Ser Val Gly Leu Val Tyr Trp Glu 
305                 310                 315                 320 


Ile Ala Arg Arg Cys Ser Val Gly Gly Ile Val Glu Glu Tyr Gln Leu 
                325                 330                 335     


Pro Tyr Tyr Asp Met Val Pro Ser Asp Pro Ser Ile Glu Glu Met Arg 
            340                 345                 350         


Lys Val Val Cys Asp Gln Lys Phe Arg Pro Ser Ile Pro Asn Gln Trp 
        355                 360                 365             


Gln Ser Cys Glu Ala Leu Arg Val Met Gly Arg Ile Met Arg Glu Cys 
    370                 375                 380                 


Trp Tyr Ala Asn Gly Ala Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys 
385                 390                 395                 400 


Thr Ile Ser Gln Leu Cys Val Lys Glu Asp Cys Lys Ala 
                405                 410             


<210>  202
<211>  517
<212>  PRT
<213>  Homo Sapiens

<400>  202

Met Ala Leu Thr Pro Pro Leu Leu Leu Leu Ser Ala Gly Thr Met Thr 
1               5                   10                  15      


Leu Gly Ser Pro Arg Lys Gly Leu Leu Met Leu Leu Met Ala Leu Val 
            20                  25                  30          


Thr Gln Gly Asp Pro Val Lys Pro Ser Arg Gly Pro Leu Val Thr Cys 
        35                  40                  45              


Thr Cys Glu Ser Pro His Cys Lys Gly Pro Thr Cys Arg Gly Ala Trp 
    50                  55                  60                  


Cys Thr Val Val Leu Val Arg Glu Glu Gly Arg His Pro Gln Glu His 
65                  70                  75                  80  


Arg Gly Cys Gly Asn Leu His Arg Glu Leu Cys Arg Gly Arg Pro Thr 
                85                  90                  95      


Glu Phe Val Asn His Tyr Cys Cys Asp Ser His Leu Cys Asn His Asn 
            100                 105                 110         


Val Ser Leu Val Leu Glu Ala Thr Gln Pro Pro Ser Glu Gln Pro Gly 
        115                 120                 125             


Thr Asp Gly Gln Leu Ala Leu Ile Leu Gly Pro Val Leu Ala Leu Leu 
    130                 135                 140                 


Ala Leu Val Ala Leu Gly Val Leu Gly Leu Trp His Val Arg Arg Arg 
145                 150                 155                 160 


Gln Glu Lys Gln Arg Gly Leu His Ser Glu Leu Gly Glu Ser Ser Leu 
                165                 170                 175     


Ile Leu Lys Ala Ser Glu Gln Gly Asp Ser Met Leu Gly Asp Leu Leu 
            180                 185                 190         


Asp Ser Asp Cys Thr Thr Gly Ser Gly Ser Gly Leu Pro Phe Leu Val 
        195                 200                 205             


Gln Arg Thr Val Ala Arg Gln Val Ala Leu Val Glu Cys Val Gly Lys 
    210                 215                 220                 


Gly Arg Tyr Gly Glu Val Trp Arg Gly Leu Trp His Gly Glu Ser Val 
225                 230                 235                 240 


Ala Val Lys Ile Phe Ser Ser Arg Asp Glu Gln Ser Trp Phe Arg Glu 
                245                 250                 255     


Thr Glu Ile Tyr Asn Thr Val Leu Leu Arg His Asp Asn Ile Leu Gly 
            260                 265                 270         


Phe Ile Ala Ser Asp Met Thr Ser Arg Asn Ser Ser Thr Gln Leu Trp 
        275                 280                 285             


Leu Ile Thr His Tyr His Glu His Gly Ser Leu Tyr Asp Phe Leu Gln 
    290                 295                 300                 


Arg Gln Thr Leu Glu Pro His Leu Ala Leu Arg Leu Ala Val Ser Ala 
305                 310                 315                 320 


Ala Cys Gly Leu Ala His Leu His Val Glu Ile Phe Gly Thr Gln Gly 
                325                 330                 335     


Lys Pro Ala Ile Ala His Arg Asp Phe Lys Ser Arg Asn Val Leu Val 
            340                 345                 350         


Lys Ser Asn Leu Gln Cys Cys Ile Ala Asp Leu Gly Leu Ala Val Met 
        355                 360                 365             


His Ser Gln Gly Ser Asp Tyr Leu Asp Ile Gly Asn Asn Pro Arg Val 
    370                 375                 380                 


Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu Asp Glu Gln Ile Arg 
385                 390                 395                 400 


Thr Asp Cys Phe Glu Ser Tyr Lys Trp Thr Asp Ile Trp Ala Phe Gly 
                405                 410                 415     


Leu Val Leu Trp Glu Ile Ala Arg Arg Thr Ile Val Asn Gly Ile Val 
            420                 425                 430         


Glu Asp Tyr Arg Pro Pro Phe Tyr Asp Val Val Pro Asn Asp Pro Ser 
        435                 440                 445             


Phe Glu Asp Met Lys Lys Val Val Cys Val Asp Gln Gln Thr Pro Thr 
    450                 455                 460                 


Ile Pro Asn Arg Leu Ala Ala Asp Pro Val Leu Ser Gly Leu Ala Gln 
465                 470                 475                 480 


Met Met Arg Glu Cys Trp Tyr Pro Asn Pro Ser Ala Arg Leu Thr Ala 
                485                 490                 495     


Leu Arg Ile Lys Lys Thr Leu Gln Lys Ile Ser Asn Ser Pro Glu Lys 
            500                 505                 510         


Pro Lys Val Ile Gln 
        515         


<210>  203
<211>  159
<212>  PRT
<213>  Homo Sapiens

<400>  203

Met Ala Leu Thr Pro Pro Leu Leu Leu Leu Ser Ala Gly Thr Met Thr 
1               5                   10                  15      


Leu Gly Ser Pro Arg Lys Gly Leu Leu Met Leu Leu Met Ala Leu Val 
            20                  25                  30          


Thr Gln Gly Asp Pro Val Lys Pro Ser Arg Gly Pro Leu Val Thr Cys 
        35                  40                  45              


Thr Cys Glu Ser Pro His Cys Lys Gly Pro Thr Cys Arg Gly Ala Trp 
    50                  55                  60                  


Cys Thr Val Val Leu Val Arg Glu Glu Gly Arg His Pro Gln Glu His 
65                  70                  75                  80  


Arg Gly Cys Gly Asn Leu His Arg Glu Leu Cys Arg Gly Arg Pro Thr 
                85                  90                  95      


Glu Phe Val Asn His Tyr Cys Cys Asp Ser His Leu Cys Asn His Asn 
            100                 105                 110         


Val Ser Leu Val Leu Glu Gly Lys Gly Arg Tyr Gly Glu Val Trp Arg 
        115                 120                 125             


Gly Leu Trp His Gly Glu Ser Val Ala Val Lys Ile Phe Ser Ser Arg 
    130                 135                 140                 


Asp Glu Gln Ser Trp Phe Arg Glu Thr Glu Ile Tyr Asn Thr Val 
145                 150                 155                 


<210>  204
<211>  329
<212>  PRT
<213>  Homo Sapiens

<400>  204

Met Ala Leu Thr Pro Pro Leu Leu Leu Leu Ser Ala Gly Thr Met Thr 
1               5                   10                  15      


Leu Gly Ser Pro Arg Lys Gly Leu Leu Met Leu Leu Met Ala Leu Val 
            20                  25                  30          


Thr Gln Gly Lys Gly Arg Tyr Gly Glu Val Trp Arg Gly Leu Trp His 
        35                  40                  45              


Gly Glu Ser Val Ala Val Lys Ile Phe Ser Ser Arg Asp Glu Gln Ser 
    50                  55                  60                  


Trp Phe Arg Glu Thr Glu Ile Tyr Asn Thr Val Leu Leu Arg His Asp 
65                  70                  75                  80  


Asn Ile Leu Gly Phe Ile Ala Ser Asp Met Thr Ser Arg Asn Ser Ser 
                85                  90                  95      


Thr Gln Leu Trp Leu Ile Thr His Tyr His Glu His Gly Ser Leu Tyr 
            100                 105                 110         


Asp Phe Leu Gln Arg Gln Thr Leu Glu Pro His Leu Ala Leu Arg Leu 
        115                 120                 125             


Ala Val Ser Ala Ala Cys Gly Leu Ala His Leu His Val Glu Ile Phe 
    130                 135                 140                 


Gly Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp Phe Lys Ser Arg 
145                 150                 155                 160 


Asn Val Leu Val Lys Ser Asn Leu Gln Cys Cys Ile Ala Asp Leu Gly 
                165                 170                 175     


Leu Ala Val Met His Ser Gln Gly Ser Asp Tyr Leu Asp Ile Gly Asn 
            180                 185                 190         


Asn Pro Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu Asp 
        195                 200                 205             


Glu Gln Ile Arg Thr Asp Cys Phe Glu Ser Tyr Lys Trp Thr Asp Ile 
    210                 215                 220                 


Trp Ala Phe Gly Leu Val Leu Trp Glu Ile Ala Arg Arg Thr Ile Val 
225                 230                 235                 240 


Asn Gly Ile Val Glu Asp Tyr Arg Pro Pro Phe Tyr Asp Val Val Pro 
                245                 250                 255     


Asn Asp Pro Ser Phe Glu Asp Met Lys Lys Val Val Cys Val Asp Gln 
            260                 265                 270         


Gln Thr Pro Thr Ile Pro Asn Arg Leu Ala Ala Asp Pro Val Leu Ser 
        275                 280                 285             


Gly Leu Ala Gln Met Met Arg Glu Cys Trp Tyr Pro Asn Pro Ser Ala 
    290                 295                 300                 


Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Gln Lys Ile Ser Asn 
305                 310                 315                 320 


Ser Pro Glu Lys Pro Lys Val Ile Gln 
                325                 


<210>  205
<211>  89
<212>  PRT
<213>  Homo Sapiens

<400>  205

Met Thr Leu Gly Ser Pro Arg Lys Gly Leu Leu Met Leu Leu Met Ala 
1               5                   10                  15      


Leu Val Thr Gln Gly Asp Pro Val Lys Pro Ser Arg Gly Pro Leu Val 
            20                  25                  30          


Thr Cys Thr Cys Glu Ser Pro His Cys Lys Gly Pro Thr Cys Arg Gly 
        35                  40                  45              


Ala Trp Cys Thr Val Val Leu Val Arg Glu Glu Gly Arg His Pro Gln 
    50                  55                  60                  


Glu His Arg Gly Cys Gly Asn Leu His Arg Glu Leu Cys Arg Gly Arg 
65                  70                  75                  80  


Pro Thr Glu Phe Val Asn His Tyr Cys 
                85                  


<210>  206
<211>  503
<212>  PRT
<213>  Homo Sapiens

<400>  206

Met Thr Leu Gly Ser Pro Arg Lys Gly Leu Leu Met Leu Leu Met Ala 
1               5                   10                  15      


Leu Val Thr Gln Gly Asp Pro Val Lys Pro Ser Arg Gly Pro Leu Val 
            20                  25                  30          


Thr Cys Thr Cys Glu Ser Pro His Cys Lys Gly Pro Thr Cys Arg Gly 
        35                  40                  45              


Ala Trp Cys Thr Val Val Leu Val Arg Glu Glu Gly Arg His Pro Gln 
    50                  55                  60                  


Glu His Arg Gly Cys Gly Asn Leu His Arg Glu Leu Cys Arg Gly Arg 
65                  70                  75                  80  


Pro Thr Glu Phe Val Asn His Tyr Cys Cys Asp Ser His Leu Cys Asn 
                85                  90                  95      


His Asn Val Ser Leu Val Leu Glu Ala Thr Gln Pro Pro Ser Glu Gln 
            100                 105                 110         


Pro Gly Thr Asp Gly Gln Leu Ala Leu Ile Leu Gly Pro Val Leu Ala 
        115                 120                 125             


Leu Leu Ala Leu Val Ala Leu Gly Val Leu Gly Leu Trp His Val Arg 
    130                 135                 140                 


Arg Arg Gln Glu Lys Gln Arg Gly Leu His Ser Glu Leu Gly Glu Ser 
145                 150                 155                 160 


Ser Leu Ile Leu Lys Ala Ser Glu Gln Gly Asp Ser Met Leu Gly Asp 
                165                 170                 175     


Leu Leu Asp Ser Asp Cys Thr Thr Gly Ser Gly Ser Gly Leu Pro Phe 
            180                 185                 190         


Leu Val Gln Arg Thr Val Ala Arg Gln Val Ala Leu Val Glu Cys Val 
        195                 200                 205             


Gly Lys Gly Arg Tyr Gly Glu Val Trp Arg Gly Leu Trp His Gly Glu 
    210                 215                 220                 


Ser Val Ala Val Lys Ile Phe Ser Ser Arg Asp Glu Gln Ser Trp Phe 
225                 230                 235                 240 


Arg Glu Thr Glu Ile Tyr Asn Thr Val Leu Leu Arg His Asp Asn Ile 
                245                 250                 255     


Leu Gly Phe Ile Ala Ser Asp Met Thr Ser Arg Asn Ser Ser Thr Gln 
            260                 265                 270         


Leu Trp Leu Ile Thr His Tyr His Glu His Gly Ser Leu Tyr Asp Phe 
        275                 280                 285             


Leu Gln Arg Gln Thr Leu Glu Pro His Leu Ala Leu Arg Leu Ala Val 
    290                 295                 300                 


Ser Ala Ala Cys Gly Leu Ala His Leu His Val Glu Ile Phe Gly Thr 
305                 310                 315                 320 


Gln Gly Lys Pro Ala Ile Ala His Arg Asp Phe Lys Ser Arg Asn Val 
                325                 330                 335     


Leu Val Lys Ser Asn Leu Gln Cys Cys Ile Ala Asp Leu Gly Leu Ala 
            340                 345                 350         


Val Met His Ser Gln Gly Ser Asp Tyr Leu Asp Ile Gly Asn Asn Pro 
        355                 360                 365             


Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu Asp Glu Gln 
    370                 375                 380                 


Ile Arg Thr Asp Cys Phe Glu Ser Tyr Lys Trp Thr Asp Ile Trp Ala 
385                 390                 395                 400 


Phe Gly Leu Val Leu Trp Glu Ile Ala Arg Arg Thr Ile Val Asn Gly 
                405                 410                 415     


Ile Val Glu Asp Tyr Arg Pro Pro Phe Tyr Asp Val Val Pro Asn Asp 
            420                 425                 430         


Pro Ser Phe Glu Asp Met Lys Lys Val Val Cys Val Asp Gln Gln Thr 
        435                 440                 445             


Pro Thr Ile Pro Asn Arg Leu Ala Ala Asp Pro Val Leu Ser Gly Leu 
    450                 455                 460                 


Ala Gln Met Met Arg Glu Cys Trp Tyr Pro Asn Pro Ser Ala Arg Leu 
465                 470                 475                 480 


Thr Ala Leu Arg Ile Lys Lys Thr Leu Gln Lys Ile Ser Asn Ser Pro 
                485                 490                 495     


Glu Lys Pro Lys Val Ile Gln 
            500             


<210>  207
<211>  163
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  207

Xaa Ser Arg Asn Val Leu Val Lys Ser Asn Leu Gln Cys Cys Ile Ala 
1               5                   10                  15      


Asp Leu Gly Leu Ala Val Met His Ser Gln Gly Ser Asp Tyr Leu Asp 
            20                  25                  30          


Ile Gly Asn Asn Pro Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu 
        35                  40                  45              


Val Leu Asp Glu Gln Ile Arg Thr Asp Cys Phe Glu Ser Tyr Lys Trp 
    50                  55                  60                  


Thr Asp Ile Trp Ala Phe Gly Leu Val Leu Trp Glu Ile Ala Arg Arg 
65                  70                  75                  80  


Thr Ile Val Asn Gly Ile Val Glu Asp Tyr Arg Pro Pro Phe Tyr Asp 
                85                  90                  95      


Val Val Pro Asn Asp Pro Ser Phe Glu Asp Met Lys Lys Val Val Cys 
            100                 105                 110         


Val Asp Gln Gln Thr Pro Thr Ile Pro Asn Arg Leu Ala Ala Asp Pro 
        115                 120                 125             


Val Arg Pro Leu Leu Gly Leu Gly Trp Arg Gly Val Val Ala His Gly 
    130                 135                 140                 


Trp Asp Phe Trp Ala Gln Glu Leu Val Ser Glu Ala Ser Ala Ser Ser 
145                 150                 155                 160 


His Arg Tyr 
            


<210>  208
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  208

Met Ala Glu Gly Asn Thr Leu Ile Ser Val Asp Tyr Glu Ile Phe Gly 
1               5                   10                  15      


Lys Val Gln Gly Val Phe Phe Arg Lys His Thr Gln Ala Glu Gly Lys 
            20                  25                  30          


Lys Leu Gly Leu Val Gly Trp Val Gln Asn Thr Asp Arg Gly Thr Val 
        35                  40                  45              


Gln Gly Gln Leu Gln Gly Pro Ile Ser Lys Val Arg His Met Gln Glu 
    50                  55                  60                  


Trp Leu Glu Thr Arg Gly Ser Pro Lys Ser His Ile Asp Lys Ala Asn 
65                  70                  75                  80  


Phe Asn Asn Glu Lys Val Ile Leu Lys Leu Asp Tyr Ser Asp Phe Gln 
                85                  90                  95      


Ile Val Lys 
            


<210>  209
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  209

Met Ala Glu Gly Asn Thr Leu Ile Ser Val Asp Tyr Glu Ile Phe Gly 
1               5                   10                  15      


Lys Val Gln Gly Val Phe Phe Arg Lys His Thr Gln Ala Glu Gly Lys 
            20                  25                  30          


Lys Leu Gly Leu Val Gly Trp Val Gln Asn Thr Asp Arg Gly Thr Val 
        35                  40                  45              


Gln Gly Gln Leu Gln Gly Pro Ile Ser Lys Val Arg His Met Gln Glu 
    50                  55                  60                  


Trp Leu Glu Thr Arg Gly Ser Pro Lys Ser His Ile Asp Lys Ala Asn 
65                  70                  75                  80  


Phe Asn Asn Glu Lys Val Ile Leu Lys Leu Asp Tyr Ser Asp Phe Gln 
                85                  90                  95      


Ile Val Lys 
            


<210>  210
<211>  55
<212>  PRT
<213>  Homo Sapiens

<400>  210

Met Ala Glu Gly Asn Thr Leu Ile Ser Val Asp Tyr Glu Ile Phe Gly 
1               5                   10                  15      


Lys Val Gln Gly Val Phe Phe Arg Lys His Thr Gln Glu Met Thr Val 
            20                  25                  30          


Glu Asn Arg Ile Ala Glu Thr His Ser Lys Ser Cys Val Pro Val Ser 
        35                  40                  45              


Phe Ala Thr Ser Tyr Ala Gly 
    50                  55  


<210>  211
<211>  62
<212>  PRT
<213>  Homo Sapiens

<400>  211

Met Ala Glu Gly Asn Thr Leu Ile Ser Val Asp Tyr Glu Ile Phe Gly 
1               5                   10                  15      


Lys Val Gln Gly Val Phe Phe Arg Lys His Thr Gln Glu Met Thr Val 
            20                  25                  30          


Glu Asn Arg Ile Ala Glu Thr His Ser Lys Ser Cys Val Pro Val Ser 
        35                  40                  45              


Phe Ala Thr Ser Tyr Ala Gly Ile Asn Glu Phe Lys Arg Ile 
    50                  55                  60          


<210>  212
<211>  37
<212>  PRT
<213>  Homo Sapiens

<400>  212

Met Ala Glu Gly Asn Thr Leu Ile Ser Val Asp Tyr Glu Ile Phe Gly 
1               5                   10                  15      


Lys Val Gln Gly Val Phe Phe Arg Lys His Thr Gln Val Cys Gly Leu 
            20                  25                  30          


Gln Ala Leu Gly Trp 
        35          


<210>  213
<211>  129
<212>  PRT
<213>  Homo Sapiens

<400>  213

Met Pro Ala Ser Ala Arg Leu Ala Gly Ala Gly Leu Leu Leu Ala Phe 
1               5                   10                  15      


Leu Arg Ala Leu Gly Cys Ala Gly Arg Ala Pro Gly Leu Ser Met Ala 
            20                  25                  30          


Glu Gly Asn Thr Leu Ile Ser Val Asp Tyr Glu Ile Phe Gly Lys Val 
        35                  40                  45              


Gln Gly Val Phe Phe Arg Lys His Thr Gln Ala Glu Gly Lys Lys Leu 
    50                  55                  60                  


Gly Leu Val Gly Trp Val Gln Asn Thr Asp Arg Gly Thr Val Gln Gly 
65                  70                  75                  80  


Gln Leu Gln Gly Pro Ile Ser Lys Val Arg His Met Gln Glu Trp Leu 
                85                  90                  95      


Glu Thr Arg Gly Ser Pro Lys Ser His Ile Asp Lys Ala Asn Phe Asn 
            100                 105                 110         


Asn Glu Lys Val Ile Leu Lys Leu Asp Tyr Ser Asp Phe Gln Ile Val 
        115                 120                 125             


Lys 
    


<210>  214
<211>  97
<212>  PRT
<213>  Homo Sapiens

<400>  214

Met Cys Pro Leu Pro Leu Ala Ala Ala Ala Val Ala Ala Pro Arg Ala 
1               5                   10                  15      


Pro Leu Arg Leu Leu Asn Arg Gly Leu Ala Ala Ala Met Ser Thr Ala 
            20                  25                  30          


Gln Ser Leu Lys Ser Val Asp Tyr Glu Val Phe Gly Arg Val Gln Gly 
        35                  40                  45              


Val Cys Phe Arg Met Tyr Thr Glu Asp Glu Ala Arg Lys Ile Gly Val 
    50                  55                  60                  


Val Gly Trp Val Lys Asn Thr Ser Lys Gly Thr Val Thr Gly Gln Val 
65                  70                  75                  80  


Gln Gly Pro Glu Asp Lys Val Asn Ser Met Leu Glu Cys Ser Gly Leu 
                85                  90                  95      


Ile 
    


<210>  215
<211>  98
<212>  PRT
<213>  Homo Sapiens

<400>  215

Met Cys Pro Leu Pro Leu Ala Ala Ala Ala Val Ala Ala Pro Arg Ala 
1               5                   10                  15      


Pro Leu Arg Leu Leu Asn Arg Gly Leu Ala Ala Ala Met Ser Thr Ala 
            20                  25                  30          


Gln Ser Leu Lys Ser Val Asp Tyr Glu Val Phe Gly Arg Val Gln Gly 
        35                  40                  45              


Val Cys Phe Arg Met Tyr Thr Glu Asp Glu Ala Arg Lys Ile Gly Val 
    50                  55                  60                  


Val Gly Trp Val Lys Asn Thr Ser Lys Gly Thr Val Thr Gly Gln Val 
65                  70                  75                  80  


Gln Gly Pro Glu Asp Lys Val Asn Ser Met Asn Ser Ser Ala Pro Glu 
                85                  90                  95      


Ala Gly 
        


<210>  216
<211>  40
<212>  PRT
<213>  Homo Sapiens

<400>  216

Met Leu Leu Thr Gln Ser Leu Phe Gly Gly Leu Phe Pro Arg Thr Arg 
1               5                   10                  15      


Glu Thr Met Arg Arg Glu Ala Val Pro Asp Asp Asn Glu Leu Pro Arg 
            20                  25                  30          


Asn Lys His Leu Asn Trp Lys Ser 
        35                  40  


<210>  217
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  217

Met Leu Leu Thr Gln Ser Leu Phe Gly Gly Leu Phe Pro Arg Thr Arg 
1               5                   10                  15      


Glu Thr Met Arg Arg Tyr Lys Val Ser Leu Phe Tyr Leu Gly Cys Ser 
            20                  25                  30          


Arg Thr Pro Asn Val Lys Leu Ser Ser Cys Leu Gly Leu Pro Cys Cys 
        35                  40                  45              


Trp Asp Tyr Ser Tyr Lys Phe Ile Gln Leu Ser Glu Phe Gly Phe Gly 
    50                  55                  60                  


Gln Val Ile Ile Val Ser Glu Glu Pro Trp Lys Glu Asn Ile Ser Cys 
65                  70                  75                  80  


Ser Ser Thr Thr Phe Ile Lys Ser Thr Ile Cys Leu Asn Pro Asp Ser 
                85                  90                  95      


Glu Phe Arg Pro Cys Phe Asn Ala Trp Leu Ser Leu Ile Arg Glu Asn 
            100                 105                 110         


Ala Val Gly Leu 
        115     


<210>  218
<211>  172
<212>  PRT
<213>  Homo Sapiens

<400>  218

Met Leu Leu Thr Gln Ser Leu Phe Gly Gly Leu Phe Pro Arg Thr Arg 
1               5                   10                  15      


Glu Thr Met Arg Arg Tyr Lys Val Ser Leu Phe Tyr Leu Gly Cys Ser 
            20                  25                  30          


Arg Thr Pro Asn Val Lys Leu Ser Ser Cys Leu Gly Leu Pro Cys Cys 
        35                  40                  45              


Trp Asp Tyr Ser Tyr Lys Phe Ile Gln Leu Ser Glu Phe Gly Phe Gly 
    50                  55                  60                  


Gln Val Ile Ile Val Ser Glu Glu Pro Trp Lys Glu Asn Ile Ser Cys 
65                  70                  75                  80  


Ser Ser Thr Thr Phe Ile Lys Ser Thr Ile Cys Leu Ser Val Cys Phe 
                85                  90                  95      


Arg Met Tyr Thr Glu Asp Glu Ala Arg Lys Ile Gly Val Val Gly Trp 
            100                 105                 110         


Val Lys Asn Thr Ser Lys Gly Thr Val Thr Gly Gln Val Gln Gly Pro 
        115                 120                 125             


Glu Asp Lys Val Asn Ser Met Lys Ser Trp Leu Ser Lys Val Gly Ser 
    130                 135                 140                 


Pro Ser Ser Arg Ile Asp Arg Thr Asn Phe Ser Asn Glu Lys Thr Ile 
145                 150                 155                 160 


Ser Lys Leu Glu Tyr Ser Asn Phe Ser Ile Arg Tyr 
                165                 170         


<210>  219
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  219

Met Ser Thr Ala Gln Ser Leu Lys Ser Val Asp Tyr Glu Val Phe Gly 
1               5                   10                  15      


Arg Val Gln Gly Val Cys Phe Arg Met Tyr Thr Glu Asp Glu Ala Arg 
            20                  25                  30          


Lys Ile Gly Val Val Gly Trp Val Lys Asn Thr Ser Lys Gly Thr Val 
        35                  40                  45              


Thr Gly Gln Val Gln Gly Pro Glu Asp Lys Val Asn Ser Met Lys Ser 
    50                  55                  60                  


Trp Leu Ser Lys Val Gly Ser Pro Ser Ser Arg Ile Asp Arg Thr Asn 
65                  70                  75                  80  


Phe Ser Asn Glu Lys Thr Ile Ser Lys Leu Glu Tyr Ser Asn Phe Ser 
                85                  90                  95      


Ile Arg Tyr 
            


<210>  220
<211>  83
<212>  PRT
<213>  Homo Sapiens

<400>  220

Met Thr Ala Leu Val Leu Gln Ile Glu Tyr Thr Glu Asp Glu Ala Arg 
1               5                   10                  15      


Lys Ile Gly Val Val Gly Trp Val Lys Asn Thr Ser Lys Gly Thr Val 
            20                  25                  30          


Thr Gly Gln Val Gln Gly Pro Glu Asp Lys Val Asn Ser Met Lys Ser 
        35                  40                  45              


Trp Leu Ser Lys Val Gly Ser Pro Ser Ser Arg Ile Asp Arg Thr Asn 
    50                  55                  60                  


Phe Ser Asn Glu Lys Thr Ile Ser Lys Leu Glu Tyr Ser Asn Phe Ser 
65                  70                  75                  80  


Ile Arg Tyr 
            


<210>  221
<211>  66
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  221

Xaa Ala Gln Ser Leu Lys Ser Val Asp Tyr Glu Val Phe Gly Arg Val 
1               5                   10                  15      


Gln Gly Val Cys Phe Arg Met Tyr Thr Glu Asp Glu Ala Arg Lys Ile 
            20                  25                  30          


Gly Val Val Gly Trp Val Lys Asn Thr Ser Lys Gly Thr Val Thr Gly 
        35                  40                  45              


Gln Val Gln Gly Pro Glu Asp Lys Val Asn Ser Ile Leu Ala Phe Pro 
    50                  55                  60                  


Phe Tyr 
65      


<210>  222
<211>  270
<212>  PRT
<213>  Homo Sapiens

<400>  222

Met Asp Ser Leu Glu Trp Asn Trp Ala Leu Val Tyr Glu Leu Ser Gly 
1               5                   10                  15      


Glu His His Asp Glu Glu Trp Ser Val Lys Thr Tyr Gln Glu Val Ala 
            20                  25                  30          


Gln Lys Phe Val Glu Thr His Pro Glu Phe Ile Gly Ile Lys Ile Ile 
        35                  40                  45              


Tyr Ser Asp His Arg Ser Lys Asp Val Ala Val Ile Ala Glu Ser Ile 
    50                  55                  60                  


Arg Met Ala Met Gly Leu Arg Ile Lys Phe Pro Thr Val Val Ala Gly 
65                  70                  75                  80  


Phe Asp Leu Val Gly His Glu Asp Thr Gly His Ser Leu His Asp Tyr 
                85                  90                  95      


Lys Glu Ala Leu Met Ile Pro Ala Lys Asp Gly Val Lys Leu Pro Tyr 
            100                 105                 110         


Phe Phe His Ala Gly Glu Thr Asp Trp Gln Gly Thr Ser Ile Asp Arg 
        115                 120                 125             


Asn Ile Leu Asp Ala Leu Met Leu Asn Thr Thr Arg Ile Gly His Gly 
    130                 135                 140                 


Phe Ala Leu Ser Lys His Pro Ala Val Arg Thr Tyr Ser Trp Lys Lys 
145                 150                 155                 160 


Asp Ile Pro Ile Glu Val Cys Pro Ile Ser Asn Gln Val Leu Lys Leu 
                165                 170                 175     


Val Ser Asp Leu Arg Asn His Pro Val Ala Thr Leu Met Ala Thr Gly 
            180                 185                 190         


His Pro Met Val Ile Ser Ser Asp Asp Pro Ala Met Phe Gly Ala Lys 
        195                 200                 205             


Gly Leu Ser Tyr Asp Phe Tyr Glu Val Phe Met Gly Ile Gly Gly Met 
    210                 215                 220                 


Lys Ala Asp Leu Arg Thr Leu Lys Gln Leu Ala Met Asn Ser Ile Lys 
225                 230                 235                 240 


Tyr Ser Thr Leu Leu Glu Ser Glu Lys Asn Thr Phe Met Glu Ile Trp 
                245                 250                 255     


Lys Lys Arg Trp Asp Lys Phe Ile Ala Asp Val Ala Thr Lys 
            260                 265                 270 


<210>  223
<211>  391
<212>  PRT
<213>  Homo Sapiens

<400>  223

Met Asp Trp Leu Val Arg Asn Val Thr Tyr Arg Pro His Cys His Ile 
1               5                   10                  15      


Cys Phe Thr Pro Arg Gly Ile Met Gln Phe Arg Phe Ala His Pro Thr 
            20                  25                  30          


Pro Arg Pro Ser Glu Lys Cys Ser Lys Trp Ile Leu Leu Glu Asp Tyr 
        35                  40                  45              


Arg Lys Arg Val Gln Asn Val Thr Glu Phe Asp Asp Ser Leu Leu Arg 
    50                  55                  60                  


Asn Phe Thr Leu Val Thr Gln His Pro Glu Val Ile Tyr Thr Asn Gln 
65                  70                  75                  80  


Asn Val Val Trp Ser Lys Phe Glu Thr Ile Phe Phe Thr Ile Ser Gly 
                85                  90                  95      


Leu Ile His Tyr Ala Pro Val Phe Arg Asp Tyr Val Phe Arg Ser Met 
            100                 105                 110         


Gln Glu Phe Tyr Glu Asp Asn Val Leu Tyr Met Glu Ile Arg Ala Arg 
        115                 120                 125             


Leu Leu Pro Val Tyr Glu Leu Ser Gly Glu His His Asp Glu Glu Trp 
    130                 135                 140                 


Ser Val Lys Thr Tyr Gln Glu Val Ala Gln Lys Phe Val Glu Thr His 
145                 150                 155                 160 


Pro Glu Phe Ile Gly Ile Lys Ile Ile Tyr Ser Asp His Arg Ser Lys 
                165                 170                 175     


Asp Val Ala Val Ile Ala Glu Ser Ile Arg Met Ala Met Gly Leu Arg 
            180                 185                 190         


Ile Lys Phe Pro Thr Val Val Ala Gly Phe Asp Leu Val Gly His Glu 
        195                 200                 205             


Asp Thr Gly His Ser Leu His Asp Tyr Lys Glu Ala Leu Met Ile Pro 
    210                 215                 220                 


Ala Lys Asp Gly Val Lys Leu Pro Tyr Phe Phe His Ala Gly Glu Thr 
225                 230                 235                 240 


Asp Trp Gln Gly Thr Ser Ile Asp Arg Asn Ile Leu Asp Ala Leu Met 
                245                 250                 255     


Leu Asn Thr Thr Arg Ile Gly His Gly Phe Ala Leu Ser Lys His Pro 
            260                 265                 270         


Ala Val Arg Thr Tyr Ser Trp Lys Lys Asp Ile Pro Ile Glu Val Cys 
        275                 280                 285             


Pro Ile Ser Asn Gln Val Leu Lys Leu Val Ser Asp Leu Arg Asn His 
    290                 295                 300                 


Pro Val Ala Thr Leu Met Ala Thr Gly His Pro Met Val Ile Ser Ser 
305                 310                 315                 320 


Asp Asp Pro Ala Met Phe Gly Ala Lys Gly Leu Ser Tyr Asp Phe Tyr 
                325                 330                 335     


Glu Val Phe Met Gly Ile Gly Gly Met Lys Ala Asp Leu Arg Thr Leu 
            340                 345                 350         


Lys Gln Leu Ala Met Asn Ser Ile Lys Tyr Ser Thr Leu Leu Glu Ser 
        355                 360                 365             


Glu Lys Asn Thr Phe Met Glu Ile Trp Lys Lys Arg Trp Asp Lys Phe 
    370                 375                 380                 


Ile Ala Asp Val Ala Thr Lys 
385                 390     


<210>  224
<211>  135
<212>  PRT
<213>  Homo Sapiens

<400>  224

Met Leu Val Asp Gly Pro Ser Glu Arg Pro Ala Leu Cys Phe Leu Leu 
1               5                   10                  15      


Leu Ala Val Ala Met Ser Phe Phe Gly Ser Ala Leu Ser Ile Asp Glu 
            20                  25                  30          


Thr Arg Ala His Leu Leu Leu Lys Glu Lys Met Met Arg Leu Gly Gly 
        35                  40                  45              


Arg Leu Val Leu Asn Thr Lys Glu Glu Leu Ala Asn Glu Arg Leu Met 
    50                  55                  60                  


Thr Leu Lys Ile Ala Glu Met Lys Glu Ala Met Arg Thr Leu Ile Phe 
65                  70                  75                  80  


Pro Pro Ser Met His Phe Phe Gln Ala Lys His Leu Ile Glu Arg Ser 
                85                  90                  95      


Gln Val Phe Asn Ile Leu Arg Met Met Pro Lys Gly Ala Ala Leu His 
            100                 105                 110         


Leu His Asp Ile Gly Ile Val Thr Met Asp Trp Leu Val Arg Asn Val 
        115                 120                 125             


Thr Tyr Arg Pro His Cys His 
    130                 135 


<210>  225
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  225

Met Leu Val Asp Gly Pro Ser Glu Arg Pro Ala Leu Cys Phe Leu Leu 
1               5                   10                  15      


Leu Ala Val Ala Met Ser Phe Phe Gly Ser Ala Leu Ser Ile Asp Glu 
            20                  25                  30          


Thr Arg Ala His Leu Leu Leu Lys Glu Lys Met Met Arg Leu Gly Gly 
        35                  40                  45              


Arg Leu Val Leu Asn Thr Lys Glu Glu Leu Ala Asn Glu Arg Leu Met 
    50                  55                  60                  


Thr Leu Lys Ile Ala Glu Met Lys Glu Ala Met Arg Thr Leu Ile Phe 
65                  70                  75                  80  


Pro Pro Ser Met His Phe Phe Gln Ala Lys His Leu Ile Glu Arg Ser 
                85                  90                  95      


Gln Val Phe Asn Ile Leu Arg Met Met Pro Lys Gly Ala Ala Leu His 
            100                 105                 110         


Leu His Asp Ile Gly Ile Val Thr Met Asp Trp Leu Val Arg Asn Val 
        115                 120                 125             


Thr Tyr Arg Pro His Cys His Ile Cys Phe Thr Pro Arg Gly Ile Met 
    130                 135                 140                 


Gln Phe Arg Phe Ala His Pro Thr 
145                 150         


<210>  226
<211>  511
<212>  PRT
<213>  Homo Sapiens

<400>  226

Met Leu Val Asp Gly Pro Ser Glu Arg Pro Ala Leu Cys Phe Leu Leu 
1               5                   10                  15      


Leu Ala Val Ala Met Ser Phe Phe Gly Ser Ala Leu Ser Ile Asp Glu 
            20                  25                  30          


Thr Arg Ala His Leu Leu Leu Lys Glu Lys Met Met Arg Leu Gly Gly 
        35                  40                  45              


Arg Leu Val Leu Asn Thr Lys Glu Glu Leu Ala Asn Glu Arg Leu Met 
    50                  55                  60                  


Thr Leu Lys Ile Ala Glu Met Lys Glu Ala Met Arg Thr Leu Ile Phe 
65                  70                  75                  80  


Pro Pro Ser Met His Phe Phe Gln Ala Lys His Leu Ile Glu Arg Ser 
                85                  90                  95      


Gln Val Phe Asn Ile Leu Arg Met Met Pro Lys Gly Ala Ala Leu His 
            100                 105                 110         


Leu His Asp Ile Gly Ile Val Thr Met Asp Trp Leu Val Arg Asn Val 
        115                 120                 125             


Thr Tyr Arg Pro His Cys His Ile Cys Phe Thr Pro Arg Gly Ile Met 
    130                 135                 140                 


Gln Phe Arg Phe Ala His Pro Thr Pro Arg Pro Ser Glu Lys Cys Ser 
145                 150                 155                 160 


Lys Trp Ile Leu Leu Glu Asp Tyr Arg Lys Arg Val Gln Asn Val Thr 
                165                 170                 175     


Glu Phe Asp Asp Ser Leu Leu Arg Asn Phe Thr Leu Val Thr Gln His 
            180                 185                 190         


Pro Glu Val Ile Tyr Thr Asn Gln Asn Val Val Trp Ser Lys Phe Glu 
        195                 200                 205             


Thr Ile Phe Phe Thr Ile Ser Gly Leu Ile His Tyr Ala Pro Val Phe 
    210                 215                 220                 


Arg Asp Tyr Val Phe Arg Ser Met Gln Glu Phe Tyr Glu Asp Asn Val 
225                 230                 235                 240 


Leu Tyr Met Glu Ile Arg Ala Arg Leu Leu Pro Val Tyr Glu Leu Ser 
                245                 250                 255     


Gly Glu His His Asp Glu Glu Trp Ser Val Lys Thr Tyr Gln Glu Val 
            260                 265                 270         


Ala Gln Lys Phe Val Glu Thr His Pro Glu Phe Ile Gly Ile Lys Ile 
        275                 280                 285             


Ile Tyr Ser Asp His Arg Ser Lys Asp Val Ala Val Ile Ala Glu Ser 
    290                 295                 300                 


Ile Arg Met Ala Met Gly Leu Arg Ile Lys Phe Pro Thr Val Val Ala 
305                 310                 315                 320 


Gly Phe Asp Leu Val Gly His Glu Asp Thr Gly His Ser Leu His Asp 
                325                 330                 335     


Tyr Lys Glu Ala Leu Met Ile Pro Ala Lys Asp Gly Val Lys Leu Pro 
            340                 345                 350         


Tyr Phe Phe His Ala Gly Glu Thr Asp Trp Gln Gly Thr Ser Ile Asp 
        355                 360                 365             


Arg Asn Ile Leu Asp Ala Leu Met Leu Asn Thr Thr Arg Ile Gly His 
    370                 375                 380                 


Gly Phe Ala Leu Ser Lys His Pro Ala Val Arg Thr Tyr Ser Trp Lys 
385                 390                 395                 400 


Lys Asp Ile Pro Ile Glu Val Cys Pro Ile Ser Asn Gln Val Leu Lys 
                405                 410                 415     


Leu Val Ser Asp Leu Arg Asn His Pro Val Ala Thr Leu Met Ala Thr 
            420                 425                 430         


Gly His Pro Met Val Ile Ser Ser Asp Asp Pro Ala Met Phe Gly Ala 
        435                 440                 445             


Lys Gly Leu Ser Tyr Asp Phe Tyr Glu Val Phe Met Gly Ile Gly Gly 
    450                 455                 460                 


Met Lys Ala Asp Leu Arg Thr Leu Lys Gln Leu Ala Met Asn Ser Ile 
465                 470                 475                 480 


Lys Tyr Ser Thr Leu Leu Glu Ser Glu Lys Asn Thr Phe Met Glu Ile 
                485                 490                 495     


Trp Lys Lys Arg Trp Asp Lys Phe Ile Ala Asp Val Ala Thr Lys 
            500                 505                 510     


<210>  227
<211>  511
<212>  PRT
<213>  Homo Sapiens

<400>  227

Met Leu Val Asp Gly Pro Ser Glu Arg Pro Ala Leu Cys Phe Leu Leu 
1               5                   10                  15      


Leu Ala Val Ala Met Ser Phe Phe Gly Ser Ala Leu Ser Ile Asp Glu 
            20                  25                  30          


Thr Arg Ala His Leu Leu Leu Lys Glu Lys Met Met Arg Leu Gly Gly 
        35                  40                  45              


Arg Leu Val Leu Asn Thr Lys Glu Glu Leu Ala Asn Glu Arg Leu Met 
    50                  55                  60                  


Thr Leu Lys Ile Ala Glu Met Lys Glu Ala Met Arg Thr Leu Ile Phe 
65                  70                  75                  80  


Pro Pro Ser Met His Phe Phe Gln Ala Lys His Leu Ile Glu Arg Ser 
                85                  90                  95      


Gln Val Phe Asn Ile Leu Arg Met Met Pro Lys Gly Ala Ala Leu His 
            100                 105                 110         


Leu His Asp Ile Gly Ile Val Thr Met Asp Trp Leu Val Arg Asn Val 
        115                 120                 125             


Thr Tyr Arg Pro His Cys His Ile Cys Phe Thr Pro Arg Gly Ile Met 
    130                 135                 140                 


Gln Phe Arg Phe Ala His Pro Thr Pro Arg Pro Ser Glu Lys Cys Ser 
145                 150                 155                 160 


Lys Trp Ile Leu Leu Glu Asp Tyr Arg Lys Arg Val Gln Asn Val Thr 
                165                 170                 175     


Glu Phe Asp Asp Ser Leu Leu Arg Asn Phe Thr Leu Val Thr Gln His 
            180                 185                 190         


Pro Glu Val Ile Tyr Thr Asn Gln Asn Val Val Trp Ser Lys Phe Glu 
        195                 200                 205             


Thr Ile Phe Phe Thr Ile Ser Gly Leu Ile His Tyr Ala Pro Val Phe 
    210                 215                 220                 


Arg Asp Tyr Val Phe Arg Ser Met Gln Glu Phe Tyr Glu Asp Asn Val 
225                 230                 235                 240 


Leu Tyr Met Glu Ile Arg Ala Arg Leu Leu Pro Val Tyr Glu Leu Ser 
                245                 250                 255     


Gly Glu His His Asp Glu Glu Trp Ser Val Lys Thr Tyr Gln Glu Val 
            260                 265                 270         


Ala Gln Lys Phe Val Glu Thr His Pro Glu Phe Ile Gly Ile Lys Ile 
        275                 280                 285             


Ile Tyr Ser Asp His Arg Ser Lys Asp Val Ala Val Ile Ala Glu Ser 
    290                 295                 300                 


Ile Arg Met Ala Met Gly Leu Arg Ile Lys Phe Pro Thr Val Val Ala 
305                 310                 315                 320 


Gly Phe Asp Leu Val Gly His Glu Asp Thr Gly His Ser Leu His Asp 
                325                 330                 335     


Tyr Lys Glu Ala Leu Met Ile Pro Ala Lys Asp Gly Val Lys Leu Pro 
            340                 345                 350         


Tyr Phe Phe His Ala Gly Glu Thr Asp Trp Gln Gly Thr Ser Ile Asp 
        355                 360                 365             


Arg Asn Ile Leu Asp Ala Leu Met Leu Asn Thr Thr Arg Ile Gly His 
    370                 375                 380                 


Gly Phe Ala Leu Ser Lys His Pro Ala Val Arg Thr Tyr Ser Trp Lys 
385                 390                 395                 400 


Lys Asp Ile Pro Ile Glu Val Cys Pro Ile Ser Asn Gln Val Leu Lys 
                405                 410                 415     


Leu Val Ser Asp Leu Arg Asn His Pro Val Ala Thr Leu Met Ala Thr 
            420                 425                 430         


Gly His Pro Met Val Ile Ser Ser Asp Asp Pro Ala Met Phe Gly Ala 
        435                 440                 445             


Lys Gly Leu Ser Tyr Asp Phe Tyr Glu Val Phe Met Gly Ile Gly Gly 
    450                 455                 460                 


Met Lys Ala Asp Leu Arg Thr Leu Lys Gln Leu Ala Met Asn Ser Ile 
465                 470                 475                 480 


Lys Tyr Ser Thr Leu Leu Glu Ser Glu Lys Asn Thr Phe Met Glu Ile 
                485                 490                 495     


Trp Lys Lys Arg Trp Asp Lys Phe Ile Ala Asp Val Ala Thr Lys 
            500                 505                 510     


<210>  228
<211>  511
<212>  PRT
<213>  Homo Sapiens

<400>  228

Met Leu Val Asp Gly Pro Ser Glu Arg Pro Ala Leu Cys Phe Leu Leu 
1               5                   10                  15      


Leu Ala Val Ala Met Ser Phe Phe Gly Ser Ala Leu Ser Ile Asp Glu 
            20                  25                  30          


Thr Arg Ala His Leu Leu Leu Lys Glu Lys Met Met Arg Leu Gly Gly 
        35                  40                  45              


Arg Leu Val Leu Asn Thr Lys Glu Glu Leu Ala Asn Glu Arg Leu Met 
    50                  55                  60                  


Thr Leu Lys Ile Ala Glu Met Lys Glu Ala Met Arg Thr Leu Ile Phe 
65                  70                  75                  80  


Pro Pro Ser Met His Phe Phe Gln Ala Lys His Leu Ile Glu Arg Ser 
                85                  90                  95      


Gln Val Phe Asn Ile Leu Arg Met Met Pro Lys Gly Ala Ala Leu His 
            100                 105                 110         


Leu His Asp Ile Gly Ile Val Thr Met Asp Trp Leu Val Arg Asn Val 
        115                 120                 125             


Thr Tyr Arg Pro His Cys His Ile Cys Phe Thr Pro Arg Gly Ile Met 
    130                 135                 140                 


Gln Phe Arg Phe Ala His Pro Thr Pro Arg Pro Ser Glu Lys Cys Ser 
145                 150                 155                 160 


Lys Trp Ile Leu Leu Glu Asp Tyr Arg Lys Arg Val Gln Asn Val Thr 
                165                 170                 175     


Glu Phe Asp Asp Ser Leu Leu Arg Asn Phe Thr Leu Val Thr Gln His 
            180                 185                 190         


Pro Glu Val Ile Tyr Thr Asn Gln Asn Val Val Trp Ser Lys Phe Glu 
        195                 200                 205             


Thr Ile Phe Phe Thr Ile Ser Gly Leu Ile His Tyr Ala Pro Val Phe 
    210                 215                 220                 


Arg Asp Tyr Val Phe Arg Ser Met Gln Glu Phe Tyr Glu Asp Asn Val 
225                 230                 235                 240 


Leu Tyr Met Glu Ile Arg Ala Arg Leu Leu Pro Val Tyr Glu Leu Ser 
                245                 250                 255     


Gly Glu His His Asp Glu Glu Trp Ser Val Lys Thr Tyr Gln Glu Val 
            260                 265                 270         


Ala Gln Lys Phe Val Glu Thr His Pro Glu Phe Ile Gly Ile Lys Ile 
        275                 280                 285             


Ile Tyr Ser Asp His Arg Ser Lys Asp Val Ala Val Ile Ala Glu Ser 
    290                 295                 300                 


Ile Arg Met Ala Met Gly Leu Arg Ile Lys Phe Pro Thr Val Val Ala 
305                 310                 315                 320 


Gly Phe Asp Leu Val Gly His Glu Asp Thr Gly His Ser Leu His Asp 
                325                 330                 335     


Tyr Lys Glu Ala Leu Met Ile Pro Ala Lys Asp Gly Val Lys Leu Pro 
            340                 345                 350         


Tyr Phe Phe His Ala Gly Glu Thr Asp Trp Gln Gly Thr Ser Ile Asp 
        355                 360                 365             


Arg Asn Ile Leu Asp Ala Leu Met Leu Asn Thr Thr Arg Ile Gly His 
    370                 375                 380                 


Gly Phe Ala Leu Ser Lys His Pro Ala Val Arg Thr Tyr Ser Trp Lys 
385                 390                 395                 400 


Lys Asp Ile Pro Ile Glu Val Cys Pro Ile Ser Asn Gln Val Leu Lys 
                405                 410                 415     


Leu Val Ser Asp Leu Arg Asn His Pro Val Ala Thr Leu Met Ala Thr 
            420                 425                 430         


Gly His Pro Met Val Ile Ser Ser Asp Asp Pro Ala Met Phe Gly Ala 
        435                 440                 445             


Lys Gly Leu Ser Tyr Asp Phe Tyr Glu Val Phe Met Gly Ile Gly Gly 
    450                 455                 460                 


Met Lys Ala Asp Leu Arg Thr Leu Lys Gln Leu Ala Met Asn Ser Ile 
465                 470                 475                 480 


Lys Tyr Ser Thr Leu Leu Glu Ser Glu Lys Asn Thr Phe Met Glu Ile 
                485                 490                 495     


Trp Lys Lys Arg Trp Asp Lys Phe Ile Ala Asp Val Ala Thr Lys 
            500                 505                 510     


<210>  229
<211>  469
<212>  PRT
<213>  Homo Sapiens

<400>  229

Met Met Arg Leu Gly Gly Arg Leu Val Leu Asn Thr Lys Glu Glu Leu 
1               5                   10                  15      


Ala Asn Glu Arg Leu Met Thr Leu Lys Ile Ala Glu Met Lys Glu Ala 
            20                  25                  30          


Met Arg Thr Leu Ile Phe Pro Pro Ser Met His Phe Phe Gln Ala Lys 
        35                  40                  45              


His Leu Ile Glu Arg Ser Gln Val Phe Asn Ile Leu Arg Met Met Pro 
    50                  55                  60                  


Lys Gly Ala Ala Leu His Leu His Asp Ile Gly Ile Val Thr Met Asp 
65                  70                  75                  80  


Trp Leu Val Arg Asn Val Thr Tyr Arg Pro His Cys His Ile Cys Phe 
                85                  90                  95      


Thr Pro Arg Gly Ile Met Gln Phe Arg Phe Ala His Pro Thr Pro Arg 
            100                 105                 110         


Pro Ser Glu Lys Cys Ser Lys Trp Ile Leu Leu Glu Asp Tyr Arg Lys 
        115                 120                 125             


Arg Val Gln Asn Val Thr Glu Phe Asp Asp Ser Leu Leu Arg Asn Phe 
    130                 135                 140                 


Thr Leu Val Thr Gln His Pro Glu Val Ile Tyr Thr Asn Gln Asn Val 
145                 150                 155                 160 


Val Trp Ser Lys Phe Glu Thr Ile Phe Phe Thr Ile Ser Gly Leu Ile 
                165                 170                 175     


His Tyr Ala Pro Val Phe Arg Asp Tyr Val Phe Arg Ser Met Gln Glu 
            180                 185                 190         


Phe Tyr Glu Asp Asn Val Leu Tyr Met Glu Ile Arg Ala Arg Leu Leu 
        195                 200                 205             


Pro Val Tyr Glu Leu Ser Gly Glu His His Asp Glu Glu Trp Ser Val 
    210                 215                 220                 


Lys Thr Tyr Gln Glu Val Ala Gln Lys Phe Val Glu Thr His Pro Glu 
225                 230                 235                 240 


Phe Ile Gly Ile Lys Ile Ile Tyr Ser Asp His Arg Ser Lys Asp Val 
                245                 250                 255     


Ala Val Ile Ala Glu Ser Ile Arg Met Ala Met Gly Leu Arg Ile Lys 
            260                 265                 270         


Phe Pro Thr Val Val Ala Gly Phe Asp Leu Val Gly His Glu Asp Thr 
        275                 280                 285             


Gly His Ser Leu His Asp Tyr Lys Glu Ala Leu Met Ile Pro Ala Lys 
    290                 295                 300                 


Asp Gly Val Lys Leu Pro Tyr Phe Phe His Ala Gly Glu Thr Asp Trp 
305                 310                 315                 320 


Gln Gly Thr Ser Ile Asp Arg Asn Ile Leu Asp Ala Leu Met Leu Asn 
                325                 330                 335     


Thr Thr Arg Ile Gly His Gly Phe Ala Leu Ser Lys His Pro Ala Val 
            340                 345                 350         


Arg Thr Tyr Ser Trp Lys Lys Asp Ile Pro Ile Glu Val Cys Pro Ile 
        355                 360                 365             


Ser Asn Gln Val Leu Lys Leu Val Ser Asp Leu Arg Asn His Pro Val 
    370                 375                 380                 


Ala Thr Leu Met Ala Thr Gly His Pro Met Val Ile Ser Ser Asp Asp 
385                 390                 395                 400 


Pro Ala Met Phe Gly Ala Lys Gly Leu Ser Tyr Asp Phe Tyr Glu Val 
                405                 410                 415     


Phe Met Gly Ile Gly Gly Met Lys Ala Asp Leu Arg Thr Leu Lys Gln 
            420                 425                 430         


Leu Ala Met Asn Ser Ile Lys Tyr Ser Thr Leu Leu Glu Ser Glu Lys 
        435                 440                 445             


Asn Thr Phe Met Glu Ile Trp Lys Lys Arg Trp Asp Lys Phe Ile Ala 
    450                 455                 460                 


Asp Val Ala Thr Lys 
465                 


<210>  230
<211>  59
<212>  PRT
<213>  Homo Sapiens

<400>  230

Met Val Leu Leu Arg Val Leu Ile Leu Leu Leu Ser Trp Ala Ala Gly 
1               5                   10                  15      


Met Gly Ala Pro Ala Arg Trp Arg Ile Pro Lys Ser Ser Pro Pro Pro 
            20                  25                  30          


Arg Pro Ala Ala Gln Thr Arg Gly Lys Leu Cys Cys Leu Gln Leu Gly 
        35                  40                  45              


Ser Cys Ile Val Leu Tyr Pro Ala Arg Arg Ser 
    50                  55                  


<210>  231
<211>  148
<212>  PRT
<213>  Homo Sapiens

<400>  231

Met Val Leu Leu Arg Val Leu Ile Leu Leu Leu Ser Trp Ala Ala Gly 
1               5                   10                  15      


Met Gly Asp Arg Asp Phe Asp Asp Gly Val Leu Gly Leu Ala Trp Val 
            20                  25                  30          


Gly Ala Pro Ser Gly Ser Ser Gly Gly Ile Cys Glu Lys Ser Lys Leu 
        35                  40                  45              


Tyr Ser Asp Gly Lys Lys Lys Ser Leu Asn Thr Gly Ile Ile Thr Val 
    50                  55                  60                  


Gln Asn Tyr Gly Ser His Val Pro Pro Lys Val Ser His Ile Thr Phe 
65                  70                  75                  80  


Ala His Glu Val Gly His Asn Phe Gly Ser Pro His Asp Ser Gly Thr 
                85                  90                  95      


Glu Cys Thr Pro Gly Glu Ser Lys Asn Leu Gly Gln Lys Glu Asn Gly 
            100                 105                 110         


Asn Tyr Ile Met Tyr Ala Arg Ala Thr Ser Gly Asp Lys Leu Asn Asn 
        115                 120                 125             


Asn Lys Phe Ser Leu Cys Ser Ile Arg Asn Ile Ser Gln Val Leu Glu 
    130                 135                 140                 


Lys Lys Arg Asn 
145             


<210>  232
<211>  71
<212>  PRT
<213>  Homo Sapiens

<400>  232

Met Val Leu Leu Arg Val Leu Ile Leu Leu Leu Ser Trp Ala Ala Gly 
1               5                   10                  15      


Met Gly Asp Arg Asp Phe Asp Asp Gly Val Leu Gly Leu Ala Trp Val 
            20                  25                  30          


Gly Ala Pro Ser Gly Ser Ser Gly Gly Ile Cys Glu Lys Ser Lys Leu 
        35                  40                  45              


Tyr Ser Asp Val Pro Thr Met Gly Lys Leu His Ser Lys Glu Lys Pro 
    50                  55                  60                  


Ile Lys Ser Ser Ser Pro Asn 
65                  70      


<210>  233
<211>  115
<212>  PRT
<213>  Homo Sapiens

<400>  233

Met Val Leu Leu Arg Val Leu Ile Leu Leu Leu Ser Trp Ala Ala Gly 
1               5                   10                  15      


Met Gly Gly Gln Tyr Gly Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr 
            20                  25                  30          


Glu Gly Leu Ser Tyr Asn Val Asp Ser Leu His Gln Lys His Gln Arg 
        35                  40                  45              


Ala Lys Arg Ala Val Ser His Glu Asp Gln Phe Leu Arg Leu Asp Phe 
    50                  55                  60                  


His Ala His Gly Arg Asp Gly Val Leu Pro Cys Cys Pro Gly Trp Ser 
65                  70                  75                  80  


Gln Thr Pro Gly Leu Lys Arg Ser Thr Cys Leu Ser Leu Pro Gln Cys 
                85                  90                  95      


Trp Asp Tyr Arg Cys Glu Pro Ser Pro Met Ile Ser Val Phe Asp Tyr 
            100                 105                 110         


Pro His Lys 
        115 


<210>  234
<211>  125
<212>  PRT
<213>  Homo Sapiens

<400>  234

Met Val Leu Leu Arg Val Leu Ile Leu Leu Leu Ser Trp Ala Ala Gly 
1               5                   10                  15      


Met Gly Gly Gln Tyr Gly Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr 
            20                  25                  30          


Glu Gly Leu Ser Tyr Asn Val Asp Ser Leu His Gln Lys His Gln Arg 
        35                  40                  45              


Ala Lys Arg Ala Val Ser His Glu Asp Gln Phe Leu Arg Leu Asp Phe 
    50                  55                  60                  


His Ala His Gly Arg His Phe Asn Leu Arg Met Lys Arg Asp Thr Ser 
65                  70                  75                  80  


Leu Phe Ser Asp Glu Phe Lys Val Glu Thr Ser Asn Lys Val Leu Asp 
                85                  90                  95      


Tyr Asp Thr Ser His Ile Tyr Thr Gly His Ile Tyr Asp Tyr Pro His 
            100                 105                 110         


Lys Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val 
        115                 120                 125 


<210>  235
<211>  748
<212>  PRT
<213>  Homo Sapiens

<400>  235

Met Val Leu Leu Arg Val Leu Ile Leu Leu Leu Ser Trp Ala Ala Gly 
1               5                   10                  15      


Met Gly Gly Gln Tyr Gly Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr 
            20                  25                  30          


Glu Gly Leu Ser Tyr Asn Val Asp Ser Leu His Gln Lys His Gln Arg 
        35                  40                  45              


Ala Lys Arg Ala Val Ser His Glu Asp Gln Phe Leu Arg Leu Asp Phe 
    50                  55                  60                  


His Ala His Gly Arg His Phe Asn Leu Arg Met Lys Arg Asp Thr Ser 
65                  70                  75                  80  


Leu Phe Ser Asp Glu Phe Lys Val Glu Thr Ser Asn Lys Val Leu Asp 
                85                  90                  95      


Tyr Asp Thr Ser His Ile Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly 
            100                 105                 110         


Ser Phe Ser His Gly Ser Val Ile Asp Gly Arg Phe Glu Gly Phe Ile 
        115                 120                 125             


Gln Thr Arg Gly Gly Thr Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile 
    130                 135                 140                 


Lys Asp Arg Thr Leu Pro Phe His Ser Val Ile Tyr His Glu Asp Asp 
145                 150                 155                 160 


Ile Asn Tyr Pro His Lys Tyr Gly Pro Gln Gly Gly Cys Ala Asp His 
                165                 170                 175     


Ser Val Phe Glu Arg Met Arg Lys Tyr Gln Met Thr Gly Val Glu Glu 
            180                 185                 190         


Val Thr Gln Ile Pro Gln Glu Glu His Ala Ala Asn Gly Pro Glu Leu 
        195                 200                 205             


Leu Arg Lys Lys Arg Thr Thr Ser Ala Glu Lys Asn Thr Cys Gln Leu 
    210                 215                 220                 


Tyr Ile Gln Thr Asp His Leu Phe Phe Lys Tyr Tyr Gly Thr Arg Glu 
225                 230                 235                 240 


Ala Val Ile Ala Gln Ile Ser Ser His Val Lys Ala Ile Asp Thr Ile 
                245                 250                 255     


Tyr Gln Thr Thr Asp Phe Ser Gly Ile Arg Asn Ile Ser Phe Met Val 
            260                 265                 270         


Lys Arg Ile Arg Ile Asn Thr Thr Ala Asp Glu Lys Asp Pro Thr Asn 
        275                 280                 285             


Pro Phe Arg Phe Pro Asn Ile Gly Val Glu Lys Phe Leu Glu Leu Asn 
    290                 295                 300                 


Ser Glu Gln Asn His Asp Asp Tyr Cys Leu Ala Tyr Val Phe Thr Asp 
305                 310                 315                 320 


Arg Asp Phe Asp Asp Gly Val Leu Gly Leu Ala Trp Val Gly Ala Pro 
                325                 330                 335     


Ser Gly Ser Ser Gly Gly Ile Cys Glu Lys Ser Lys Leu Tyr Ser Asp 
            340                 345                 350         


Gly Lys Lys Lys Ser Leu Asn Thr Gly Ile Ile Thr Val Gln Asn Tyr 
        355                 360                 365             


Gly Ser His Val Pro Pro Lys Val Ser His Ile Thr Phe Ala His Glu 
    370                 375                 380                 


Val Gly His Asn Phe Gly Ser Pro His Asp Ser Gly Thr Glu Cys Thr 
385                 390                 395                 400 


Pro Gly Glu Ser Lys Asn Leu Gly Gln Lys Glu Asn Gly Asn Tyr Ile 
                405                 410                 415     


Met Tyr Ala Arg Ala Thr Ser Gly Asp Lys Leu Asn Asn Asn Lys Phe 
            420                 425                 430         


Ser Leu Cys Ser Ile Arg Asn Ile Ser Gln Val Leu Glu Lys Lys Arg 
        435                 440                 445             


Asn Asn Cys Phe Val Glu Ser Gly Gln Pro Ile Cys Gly Asn Gly Met 
    450                 455                 460                 


Val Glu Gln Gly Glu Glu Cys Asp Cys Gly Tyr Ser Asp Gln Cys Lys 
465                 470                 475                 480 


Asp Glu Cys Cys Phe Asp Ala Asn Gln Pro Glu Gly Arg Lys Cys Lys 
                485                 490                 495     


Leu Lys Pro Gly Lys Gln Cys Ser Pro Ser Gln Gly Pro Cys Cys Thr 
            500                 505                 510         


Ala Gln Cys Ala Phe Lys Ser Lys Ser Glu Lys Cys Arg Asp Asp Ser 
        515                 520                 525             


Asp Cys Ala Arg Glu Gly Ile Cys Asn Gly Phe Thr Ala Leu Cys Pro 
    530                 535                 540                 


Ala Ser Asp Pro Lys Pro Asn Phe Thr Asp Cys Asn Arg His Thr Gln 
545                 550                 555                 560 


Val Cys Ile Asn Gly Gln Cys Ala Gly Ser Ile Cys Glu Lys Tyr Gly 
                565                 570                 575     


Leu Glu Glu Cys Thr Cys Ala Ser Ser Asp Gly Lys Asp Asp Lys Glu 
            580                 585                 590         


Leu Cys His Val Cys Cys Met Lys Lys Met Asp Pro Ser Thr Cys Ala 
        595                 600                 605             


Ser Thr Gly Ser Val Gln Trp Ser Arg His Phe Ser Gly Arg Thr Ile 
    610                 615                 620                 


Thr Leu Gln Pro Gly Ser Pro Cys Asn Asp Phe Arg Gly Tyr Cys Asp 
625                 630                 635                 640 


Val Phe Met Arg Cys Arg Leu Val Asp Ala Asp Gly Pro Leu Ala Arg 
                645                 650                 655     


Leu Lys Lys Ala Ile Phe Ser Pro Glu Leu Tyr Glu Asn Ile Ala Glu 
            660                 665                 670         


Trp Ile Val Ala His Trp Trp Ala Val Leu Leu Met Gly Ile Ala Leu 
        675                 680                 685             


Ile Met Leu Met Ala Gly Phe Ile Lys Ile Cys Ser Val His Thr Pro 
    690                 695                 700                 


Ser Ser Asn Pro Lys Leu Pro Pro Pro Lys Pro Leu Pro Gly Thr Leu 
705                 710                 715                 720 


Lys Arg Arg Arg Pro Pro Gln Pro Ile Gln Gln Pro Gln Arg Gln Arg 
                725                 730                 735     


Pro Arg Glu Ser Tyr Gln Met Gly His Met Arg Arg 
            740                 745             


<210>  236
<211>  38
<212>  PRT
<213>  Homo Sapiens

<400>  236

Met Val Leu Leu Arg Val Leu Ile Leu Leu Leu Ser Trp Ala Ala Gly 
1               5                   10                  15      


Met Gly Val Pro Thr Met Gly Lys Leu His Ser Lys Glu Lys Pro Ile 
            20                  25                  30          


Lys Ser Ser Ser Pro Asn 
        35              


<210>  237
<211>  58
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  237

Xaa Glu Glu Gly Ser Phe Ser His Gly Ser Val Ile Asp Gly Arg Phe 
1               5                   10                  15      


Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr Phe Tyr Val Glu Pro Ala 
            20                  25                  30          


Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro Phe His Ser Val Ile Tyr 
        35                  40                  45              


His Glu Asp Asp Ile Ser Glu Gly Leu Asn 
    50                  55              


<210>  238
<211>  278
<212>  PRT
<213>  Homo Sapiens

<400>  238

Met Ala Ala Arg Pro Leu Pro Val Ser Pro Ala Arg Ala Leu Leu Leu 
1               5                   10                  15      


Ala Leu Ala Gly Ala Leu Leu Ala Pro Cys Glu Ala Arg Gly Val Ser 
            20                  25                  30          


Leu Trp Asn Gln Gly Arg Ala Asp Glu Val Val Ser Ala Ser Val Gly 
        35                  40                  45              


Ser Gly Asp Leu Trp Ile Pro Val Lys Ser Phe Asp Ser Lys Asn His 
    50                  55                  60                  


Pro Glu Val Leu Asn Ile Arg Leu Gln Arg Glu Ser Lys Glu Leu Ile 
65                  70                  75                  80  


Ile Asn Leu Glu Arg Asn Glu Gly Leu Ile Ala Ser Ser Phe Thr Glu 
                85                  90                  95      


Thr His Tyr Leu Gln Asp Gly Thr Asp Val Ser Leu Ala Arg Asn Tyr 
            100                 105                 110         


Thr Gly His Cys Tyr Tyr His Gly His Val Arg Gly Tyr Ser Asp Ser 
        115                 120                 125             


Ala Val Ser Leu Ser Thr Cys Ser Gly Leu Arg Gly Leu Ile Val Phe 
    130                 135                 140                 


Glu Asn Glu Ser Tyr Val Leu Glu Pro Met Lys Ser Ala Thr Asn Arg 
145                 150                 155                 160 


Tyr Lys Leu Phe Pro Ala Lys Lys Leu Lys Ser Val Arg Gly Ser Cys 
                165                 170                 175     


Gly Ser His His Asn Thr Pro Asn Leu Ala Ala Lys Asn Val Phe Pro 
            180                 185                 190         


Pro Pro Ser Gln Thr Trp Ala Arg Arg His Lys Arg Glu Thr Leu Lys 
        195                 200                 205             


Ala Thr Lys Tyr Val Glu Leu Val Ile Val Ala Asp Asn Arg Glu Phe 
    210                 215                 220                 


Gln Arg Gln Gly Lys Asp Leu Glu Lys Val Lys Gln Arg Leu Ile Glu 
225                 230                 235                 240 


Ile Ala Asn His Val Asp Lys Phe Tyr Arg Pro Leu Asn Ile Arg Ile 
                245                 250                 255     


Val Leu Val Gly Val Glu Val Trp Asn Asp Met Asp Lys Cys Ser Val 
            260                 265                 270         


Ser Gln Asp Pro Phe Thr 
        275             


<210>  239
<211>  909
<212>  PRT
<213>  Homo Sapiens

<400>  239

Met Ala Ala Arg Pro Leu Pro Val Ser Pro Ala Arg Ala Leu Leu Leu 
1               5                   10                  15      


Ala Leu Ala Gly Ala Leu Leu Ala Pro Cys Glu Ala Arg Gly Val Ser 
            20                  25                  30          


Leu Trp Asn Gln Gly Arg Ala Asp Glu Val Val Ser Ala Ser Val Gly 
        35                  40                  45              


Ser Gly Asp Leu Trp Ile Pro Val Lys Ser Phe Asp Ser Lys Asn His 
    50                  55                  60                  


Pro Glu Val Leu Asn Ile Arg Leu Gln Arg Glu Ser Lys Glu Leu Ile 
65                  70                  75                  80  


Ile Asn Leu Glu Arg Asn Glu Gly Leu Ile Ala Ser Ser Phe Thr Glu 
                85                  90                  95      


Thr His Tyr Leu Gln Asp Gly Thr Asp Val Ser Leu Ala Arg Asn Tyr 
            100                 105                 110         


Thr Val Ile Leu Gly His Cys Tyr Tyr His Gly His Val Arg Gly Tyr 
        115                 120                 125             


Ser Asp Ser Ala Val Ser Leu Ser Thr Cys Ser Gly Leu Arg Gly Leu 
    130                 135                 140                 


Ile Val Phe Glu Asn Glu Ser Tyr Val Leu Glu Pro Met Lys Ser Ala 
145                 150                 155                 160 


Thr Asn Arg Tyr Lys Leu Phe Pro Ala Lys Lys Leu Lys Ser Val Arg 
                165                 170                 175     


Gly Ser Cys Gly Ser His His Asn Thr Pro Asn Leu Ala Ala Lys Asn 
            180                 185                 190         


Val Phe Pro Pro Pro Ser Gln Thr Trp Ala Arg Arg His Lys Arg Glu 
        195                 200                 205             


Thr Leu Lys Ala Thr Lys Tyr Val Glu Leu Val Ile Val Ala Asp Asn 
    210                 215                 220                 


Arg Glu Phe Gln Arg Gln Gly Lys Asp Leu Glu Lys Val Lys Gln Arg 
225                 230                 235                 240 


Leu Ile Glu Ile Ala Asn His Val Asp Lys Phe Tyr Arg Pro Leu Asn 
                245                 250                 255     


Ile Arg Ile Val Leu Val Gly Val Glu Val Trp Asn Asp Met Asp Lys 
            260                 265                 270         


Cys Ser Val Ser Gln Asp Pro Phe Thr Ser Leu His Glu Phe Leu Asp 
        275                 280                 285             


Trp Arg Lys Met Lys Leu Leu Pro Arg Lys Ser His Asp Asn Ala Gln 
    290                 295                 300                 


Leu Val Ser Gly Val Tyr Phe Gln Gly Thr Thr Ile Gly Met Ala Pro 
305                 310                 315                 320 


Ile Met Ser Met Cys Thr Ala Asp Gln Ser Gly Gly Ile Val Met Asp 
                325                 330                 335     


His Ser Asp Asn Pro Leu Gly Ala Ala Val Thr Leu Ala His Glu Leu 
            340                 345                 350         


Gly His Asn Phe Gly Met Asn His Asp Thr Leu Asp Arg Gly Cys Ser 
        355                 360                 365             


Cys Gln Met Ala Val Glu Lys Gly Gly Cys Ile Met Asn Ala Ser Thr 
    370                 375                 380                 


Gly Tyr Pro Phe Pro Met Val Phe Ser Ser Cys Ser Arg Lys Asp Leu 
385                 390                 395                 400 


Glu Thr Ser Leu Glu Lys Gly Met Gly Val Cys Leu Phe Asn Leu Pro 
                405                 410                 415     


Glu Val Arg Glu Ser Phe Gly Gly Gln Lys Cys Gly Asn Arg Phe Val 
            420                 425                 430         


Glu Glu Gly Glu Glu Cys Asp Cys Gly Glu Pro Glu Glu Cys Met Asn 
        435                 440                 445             


Arg Cys Cys Asn Ala Thr Thr Cys Thr Leu Lys Pro Asp Ala Val Cys 
    450                 455                 460                 


Ala His Gly Leu Cys Cys Glu Asp Cys Gln Leu Lys Pro Ala Gly Thr 
465                 470                 475                 480 


Ala Cys Arg Asp Ser Ser Asn Ser Cys Asp Leu Pro Glu Phe Cys Thr 
                485                 490                 495     


Gly Ala Ser Pro His Cys Pro Ala Asn Val Tyr Leu His Asp Gly His 
            500                 505                 510         


Ser Cys Gln Asp Val Asp Gly Tyr Cys Tyr Asn Gly Ile Cys Gln Thr 
        515                 520                 525             


His Glu Gln Gln Cys Val Thr Leu Trp Gly Pro Gly Ala Lys Pro Ala 
    530                 535                 540                 


Pro Gly Ile Cys Phe Glu Arg Val Asn Ser Ala Gly Asp Pro Tyr Gly 
545                 550                 555                 560 


Asn Cys Gly Lys Val Ser Lys Ser Ser Phe Ala Lys Cys Glu Met Arg 
                565                 570                 575     


Asp Ala Lys Cys Gly Lys Ile Gln Cys Gln Gly Gly Ala Ser Arg Pro 
            580                 585                 590         


Val Ile Gly Thr Asn Ala Val Ser Ile Glu Thr Asn Ile Pro Leu Gln 
        595                 600                 605             


Gln Gly Gly Arg Ile Leu Cys Arg Gly Thr His Val Tyr Leu Gly Asp 
    610                 615                 620                 


Asp Met Pro Asp Pro Gly Leu Val Leu Ala Gly Thr Lys Cys Ala Asp 
625                 630                 635                 640 


Gly Lys Ile Cys Leu Asn Arg Gln Cys Gln Asn Ile Ser Val Phe Gly 
                645                 650                 655     


Val His Glu Cys Ala Met Gln Cys His Gly Arg Gly Val Cys Asn Asn 
            660                 665                 670         


Arg Lys Asn Cys His Cys Glu Ala His Trp Ala Pro Pro Phe Cys Asp 
        675                 680                 685             


Lys Phe Gly Phe Gly Gly Ser Thr Asp Ser Gly Pro Ile Arg Gln Ala 
    690                 695                 700                 


Asp Asn Gln Gly Leu Thr Ile Gly Ile Leu Val Thr Ile Leu Cys Leu 
705                 710                 715                 720 


Leu Ala Ala Gly Phe Val Val Tyr Leu Lys Arg Lys Thr Leu Ile Arg 
                725                 730                 735     


Leu Leu Phe Thr Asn Lys Lys Thr Thr Ile Glu Lys Leu Arg Cys Val 
            740                 745                 750         


Arg Pro Ser Arg Pro Pro Arg Gly Phe Gln Pro Cys Gln Ala His Leu 
        755                 760                 765             


Gly His Leu Gly Lys Gly Leu Met Arg Lys Pro Pro Asp Ser Tyr Pro 
    770                 775                 780                 


Pro Lys Asp Asn Pro Arg Arg Leu Leu Gln Cys Gln Asn Val Asp Ile 
785                 790                 795                 800 


Ser Arg Pro Leu Asn Gly Leu Asn Val Pro Gln Pro Gln Ser Thr Gln 
                805                 810                 815     


Arg Val Leu Pro Pro Leu His Arg Ala Pro Arg Ala Pro Ser Val Pro 
            820                 825                 830         


Ala Arg Pro Leu Pro Ala Lys Pro Ala Leu Arg Gln Ala Gln Gly Thr 
        835                 840                 845             


Cys Lys Pro Asn Pro Pro Gln Lys Pro Leu Pro Ala Asp Pro Leu Ala 
    850                 855                 860                 


Arg Thr Thr Arg Leu Thr His Ala Leu Ala Arg Thr Pro Gly Gln Trp 
865                 870                 875                 880 


Glu Thr Gly Leu Arg Leu Ala Pro Leu Arg Pro Ala Pro Gln Tyr Pro 
                885                 890                 895     


His Gln Val Pro Arg Ser Thr His Thr Ala Tyr Ile Lys 
            900                 905                 


<210>  240
<211>  738
<212>  PRT
<213>  Homo Sapiens

<400>  240

Met Ala Ala Arg Pro Leu Pro Val Ser Pro Ala Arg Ala Leu Leu Leu 
1               5                   10                  15      


Ala Leu Ala Gly Ala Leu Leu Ala Pro Cys Glu Ala Arg Gly Val Ser 
            20                  25                  30          


Leu Trp Asn Gln Gly Arg Ala Asp Glu Val Val Ser Ala Ser Val Gly 
        35                  40                  45              


Ser Gly Asp Leu Trp Ile Pro Val Lys Ser Phe Asp Ser Lys Asn His 
    50                  55                  60                  


Pro Glu Val Leu Asn Ile Arg Leu Gln Arg Glu Ser Lys Glu Leu Ile 
65                  70                  75                  80  


Ile Asn Leu Glu Arg Asn Glu Gly Leu Ile Ala Ser Ser Phe Thr Glu 
                85                  90                  95      


Thr His Tyr Leu Gln Asp Gly Thr Asp Val Ser Leu Ala Arg Asn Tyr 
            100                 105                 110         


Thr Val Ile Leu Gly His Cys Tyr Tyr His Gly His Val Arg Gly Tyr 
        115                 120                 125             


Ser Asp Ser Ala Val Ser Leu Ser Thr Cys Ser Gly Leu Arg Gly Leu 
    130                 135                 140                 


Ile Val Phe Glu Asn Glu Ser Tyr Val Leu Glu Pro Met Lys Ser Ala 
145                 150                 155                 160 


Thr Asn Arg Tyr Lys Leu Phe Pro Ala Lys Lys Leu Lys Ser Val Arg 
                165                 170                 175     


Gly Ser Cys Gly Ser His His Asn Thr Pro Asn Leu Ala Ala Lys Asn 
            180                 185                 190         


Val Phe Pro Pro Pro Ser Gln Thr Trp Ala Arg Arg His Lys Arg Glu 
        195                 200                 205             


Thr Leu Lys Ala Thr Lys Tyr Val Glu Leu Val Ile Val Ala Asp Asn 
    210                 215                 220                 


Arg Glu Phe Gln Arg Gln Gly Lys Asp Leu Glu Lys Val Lys Gln Arg 
225                 230                 235                 240 


Leu Ile Glu Ile Ala Asn His Val Asp Lys Phe Tyr Arg Pro Leu Asn 
                245                 250                 255     


Ile Arg Ile Val Leu Val Gly Val Glu Val Trp Asn Asp Met Asp Lys 
            260                 265                 270         


Cys Ser Val Ser Gln Asp Pro Phe Thr Ser Leu His Glu Phe Leu Asp 
        275                 280                 285             


Trp Arg Lys Met Lys Leu Leu Pro Arg Lys Ser His Asp Asn Ala Gln 
    290                 295                 300                 


Leu Val Ser Gly Val Tyr Phe Gln Gly Thr Thr Ile Gly Met Ala Pro 
305                 310                 315                 320 


Ile Met Ser Met Cys Thr Ala Asp Gln Ser Gly Gly Ile Val Met Asp 
                325                 330                 335     


His Ser Asp Asn Pro Leu Gly Ala Ala Val Thr Leu Ala His Glu Leu 
            340                 345                 350         


Gly His Asn Phe Gly Met Asn His Asp Thr Leu Asp Arg Gly Cys Ser 
        355                 360                 365             


Cys Gln Met Ala Val Glu Lys Gly Gly Cys Ile Met Asn Ala Ser Thr 
    370                 375                 380                 


Gly Tyr Pro Phe Pro Met Val Phe Ser Ser Cys Ser Arg Lys Asp Leu 
385                 390                 395                 400 


Glu Thr Ser Leu Glu Lys Gly Met Gly Val Cys Leu Phe Asn Leu Pro 
                405                 410                 415     


Glu Val Arg Glu Ser Phe Gly Gly Gln Lys Cys Gly Asn Arg Phe Val 
            420                 425                 430         


Glu Glu Gly Glu Glu Cys Asp Cys Gly Glu Pro Glu Glu Cys Met Asn 
        435                 440                 445             


Arg Cys Cys Asn Ala Thr Thr Cys Thr Leu Lys Pro Asp Ala Val Cys 
    450                 455                 460                 


Ala His Gly Leu Cys Cys Glu Asp Cys Gln Leu Lys Pro Ala Gly Thr 
465                 470                 475                 480 


Ala Cys Arg Asp Ser Ser Asn Ser Cys Asp Leu Pro Glu Phe Cys Thr 
                485                 490                 495     


Gly Ala Ser Pro His Cys Pro Ala Asn Val Tyr Leu His Asp Gly His 
            500                 505                 510         


Ser Cys Gln Asp Val Asp Gly Tyr Cys Tyr Asn Gly Ile Cys Gln Thr 
        515                 520                 525             


His Glu Gln Gln Cys Val Thr Leu Trp Gly Pro Gly Ala Lys Pro Ala 
    530                 535                 540                 


Pro Gly Ile Cys Phe Glu Arg Val Asn Ser Ala Gly Asp Pro Tyr Gly 
545                 550                 555                 560 


Asn Cys Gly Lys Val Ser Lys Ser Ser Phe Ala Lys Cys Glu Met Arg 
                565                 570                 575     


Asp Ala Lys Cys Gly Lys Ile Gln Cys Gln Gly Gly Ala Ser Arg Pro 
            580                 585                 590         


Val Ile Gly Thr Asn Ala Val Ser Ile Glu Thr Asn Ile Pro Leu Gln 
        595                 600                 605             


Gln Gly Gly Arg Ile Leu Cys Arg Gly Thr His Val Tyr Leu Gly Asp 
    610                 615                 620                 


Asp Met Pro Asp Pro Gly Leu Val Leu Ala Gly Thr Lys Cys Ala Asp 
625                 630                 635                 640 


Gly Lys Ile Cys Leu Asn Arg Gln Cys Gln Asn Ile Ser Val Phe Gly 
                645                 650                 655     


Val His Glu Cys Ala Met Gln Cys His Gly Arg Gly Val Cys Asn Asn 
            660                 665                 670         


Arg Lys Asn Cys His Cys Glu Ala His Trp Ala Pro Pro Phe Cys Asp 
        675                 680                 685             


Lys Phe Gly Phe Gly Gly Ser Thr Asp Ser Gly Pro Ile Arg Gln Ala 
    690                 695                 700                 


Glu Ala Arg Gln Glu Ala Ala Glu Ser Asn Arg Glu Arg Gly Gln Gly 
705                 710                 715                 720 


Gln Glu Pro Val Gly Ser Gln Glu His Ala Ser Thr Ala Ser Leu Thr 
                725                 730                 735     


Leu Ile 
        


<210>  241
<211>  520
<212>  PRT
<213>  Homo Sapiens

<400>  241

Met Arg Leu Ala Leu Leu Trp Ala Leu Gly Leu Leu Gly Ala Gly Ser 
1               5                   10                  15      


Pro Leu Pro Ser Trp Pro Leu Pro Asn Ile Gly Gly Thr Glu Glu Gln 
            20                  25                  30          


Gln Ala Glu Ser Glu Lys Ala Pro Arg Glu Pro Leu Glu Pro Gln Val 
        35                  40                  45              


Leu Gln Asp Asp Leu Pro Ile Ser Leu Lys Lys Val Leu Gln Thr Ser 
    50                  55                  60                  


Leu Pro Glu Pro Leu Arg Ile Lys Leu Glu Leu Asp Gly Asp Ser His 
65                  70                  75                  80  


Ile Leu Glu Leu Leu Gln Asn Arg Glu Leu Val Pro Gly Leu Asn Phe 
                85                  90                  95      


Ser Asn Cys Ser Arg Arg Ala Leu Glu Lys Ala Leu Leu Asp Gly Met 
            100                 105                 110         


Gly Ser Cys Leu Phe Glu Arg Leu Pro Ser Leu Pro Pro Met Ala Ala 
        115                 120                 125             


Phe Cys Gly Asn Met Phe Val Glu Pro Gly Glu Gln Cys Asp Cys Gly 
    130                 135                 140                 


Phe Leu Asp Asp Cys Val Asp Pro Cys Cys Asp Ser Leu Thr Cys Gln 
145                 150                 155                 160 


Leu Arg Pro Gly Ala Gln Cys Ala Ser Asp Gly Pro Cys Cys Gln Asn 
                165                 170                 175     


Cys Gln Leu Arg Pro Ser Gly Trp Gln Cys Arg Pro Thr Arg Gly Asp 
            180                 185                 190         


Cys Asp Leu Pro Glu Phe Cys Pro Gly Asp Ser Ser Gln Cys Pro Pro 
        195                 200                 205             


Asp Val Ser Leu Gly Asp Gly Glu Pro Cys Ala Gly Gly Gln Ala Val 
    210                 215                 220                 


Cys Met His Gly Arg Cys Ala Ser Tyr Ala Gln Gln Cys Gln Ser Leu 
225                 230                 235                 240 


Trp Gly Pro Gly Ala Gln Pro Ala Ala Pro Leu Cys Leu Gln Thr Ala 
                245                 250                 255     


Asn Thr Arg Gly Asn Ala Phe Gly Ser Cys Gly Arg Asn Pro Ser Gly 
            260                 265                 270         


Ser Tyr Val Ser Cys Thr Pro Arg Asp Ala Ile Cys Gly Gln Leu Gln 
        275                 280                 285             


Cys Gln Thr Gly Arg Thr Gln Pro Leu Leu Gly Ser Ile Arg Asp Leu 
    290                 295                 300                 


Leu Trp Glu Thr Ile Asp Val Asn Gly Thr Glu Leu Asn Cys Ser Trp 
305                 310                 315                 320 


Val His Leu Asp Leu Gly Ser Asp Val Ala Gln Pro Leu Leu Thr Leu 
                325                 330                 335     


Pro Gly Thr Ala Cys Gly Pro Gly Leu Val Cys Ile Asp His Arg Cys 
            340                 345                 350         


Gln Arg Val Asp Leu Leu Gly Ala Gln Glu Cys Arg Ser Lys Cys His 
        355                 360                 365             


Gly His Gly Val Cys Asp Ser Asn Arg His Cys Tyr Cys Glu Glu Gly 
    370                 375                 380                 


Trp Ala Pro Pro Asp Cys Thr Thr Gln Leu Lys Ala Thr Ser Ser Leu 
385                 390                 395                 400 


Thr Thr Gly Leu Leu Leu Ser Leu Leu Val Leu Leu Val Leu Val Met 
                405                 410                 415     


Leu Gly Ala Ser Tyr Trp Tyr Arg Ala Arg Leu His Gln Arg Leu Cys 
            420                 425                 430         


Gln Leu Lys Gly Pro Thr Cys Gln Tyr Arg Ala Ala Gln Ser Gly Pro 
        435                 440                 445             


Ser Glu Arg Pro Gly Pro Pro Gln Arg Ala Leu Leu Ala Arg Gly Thr 
    450                 455                 460                 


Lys Ser Gln Gly Pro Ala Lys Pro Pro Pro Pro Arg Lys Pro Leu Pro 
465                 470                 475                 480 


Ala Asp Pro Gln Gly Arg Cys Pro Ser Gly Asp Leu Pro Gly Pro Gly 
                485                 490                 495     


Ala Gly Ile Pro Pro Leu Val Val Pro Ser Arg Pro Ala Pro Pro Pro 
            500                 505                 510         


Pro Thr Val Ser Ser Leu Tyr Leu 
        515                 520 


<210>  242
<211>  814
<212>  PRT
<213>  Homo Sapiens

<400>  242

Met Arg Leu Ala Leu Leu Trp Ala Leu Gly Leu Leu Gly Ala Gly Ser 
1               5                   10                  15      


Pro Leu Pro Ser Trp Pro Leu Pro Asn Ile Gly Gly Thr Glu Glu Gln 
            20                  25                  30          


Gln Ala Glu Ser Glu Lys Ala Pro Arg Glu Pro Leu Glu Pro Gln Val 
        35                  40                  45              


Leu Gln Asp Asp Leu Pro Ile Ser Leu Lys Lys Val Leu Gln Thr Ser 
    50                  55                  60                  


Leu Pro Glu Pro Leu Arg Ile Lys Leu Glu Leu Asp Gly Asp Ser His 
65                  70                  75                  80  


Ile Leu Glu Leu Leu Gln Asn Arg Glu Leu Val Pro Gly Arg Pro Thr 
                85                  90                  95      


Leu Val Trp Tyr Gln Pro Asp Gly Thr Arg Val Val Ser Glu Gly His 
            100                 105                 110         


Thr Leu Glu Asn Cys Cys Tyr Gln Gly Arg Val Arg Gly Tyr Ala Gly 
        115                 120                 125             


Ser Trp Val Ser Ile Cys Thr Cys Ser Gly Leu Arg Gly Leu Val Val 
    130                 135                 140                 


Leu Thr Pro Glu Arg Ser Tyr Thr Leu Glu Gln Gly Pro Gly Asp Leu 
145                 150                 155                 160 


Gln Gly Pro Pro Ile Ile Ser Arg Ile Gln Asp Leu His Leu Pro Gly 
                165                 170                 175     


His Thr Cys Ala Leu Ser Trp Arg Glu Ser Val His Thr Gln Lys Pro 
            180                 185                 190         


Pro Glu His Pro Leu Gly Gln Arg His Ile Arg Arg Arg Arg Asp Val 
        195                 200                 205             


Val Thr Glu Thr Lys Thr Val Glu Leu Val Ile Val Ala Asp His Ser 
    210                 215                 220                 


Glu Ala Gln Lys Tyr Arg Asp Phe Gln His Leu Leu Asn Arg Thr Leu 
225                 230                 235                 240 


Glu Val Ala Leu Leu Leu Asp Thr Phe Phe Arg Pro Leu Asn Val Arg 
                245                 250                 255     


Val Ala Leu Val Gly Leu Glu Ala Trp Thr Gln Arg Asp Leu Val Glu 
            260                 265                 270         


Ile Ser Pro Asn Pro Ala Val Thr Leu Glu Asn Phe Leu His Trp Arg 
        275                 280                 285             


Arg Ala His Leu Leu Pro Arg Leu Pro His Asp Ser Ala Gln Leu Val 
    290                 295                 300                 


Thr Gly Thr Ser Phe Ser Gly Pro Thr Val Gly Met Ala Ile Gln Asn 
305                 310                 315                 320 


Ser Ile Cys Ser Pro Asp Phe Ser Gly Gly Val Asn Met Asp His Ser 
                325                 330                 335     


Thr Ser Ile Leu Gly Val Ala Ser Ser Ile Ala His Glu Leu Gly His 
            340                 345                 350         


Ser Leu Gly Leu Asp His Asp Leu Pro Gly Asn Ser Cys Pro Cys Pro 
        355                 360                 365             


Gly Pro Ala Pro Ala Lys Thr Cys Ile Met Glu Ala Ser Thr Asp Phe 
    370                 375                 380                 


Leu Pro Gly Leu Asn Phe Ser Asn Cys Ser Arg Arg Ala Leu Glu Lys 
385                 390                 395                 400 


Ala Leu Leu Asp Gly Met Gly Ser Cys Leu Phe Glu Arg Leu Pro Ser 
                405                 410                 415     


Leu Pro Pro Met Ala Ala Phe Cys Gly Asn Met Phe Val Glu Pro Gly 
            420                 425                 430         


Glu Gln Cys Asp Cys Gly Phe Leu Asp Asp Cys Val Asp Pro Cys Cys 
        435                 440                 445             


Asp Ser Leu Thr Cys Gln Leu Arg Pro Gly Ala Gln Cys Ala Ser Asp 
    450                 455                 460                 


Gly Pro Cys Cys Gln Asn Cys Gln Leu Arg Pro Ser Gly Trp Gln Cys 
465                 470                 475                 480 


Arg Pro Thr Arg Gly Asp Cys Asp Leu Pro Glu Phe Cys Pro Gly Asp 
                485                 490                 495     


Ser Ser Gln Cys Pro Pro Asp Val Ser Leu Gly Asp Gly Glu Pro Cys 
            500                 505                 510         


Ala Gly Gly Gln Ala Val Cys Met His Gly Arg Cys Ala Ser Tyr Ala 
        515                 520                 525             


Gln Gln Cys Gln Ser Leu Trp Gly Pro Gly Ala Gln Pro Ala Ala Pro 
    530                 535                 540                 


Leu Cys Leu Gln Thr Ala Asn Thr Arg Gly Asn Ala Phe Gly Ser Cys 
545                 550                 555                 560 


Gly Arg Asn Pro Ser Gly Ser Tyr Val Ser Cys Thr Pro Arg Asp Ala 
                565                 570                 575     


Ile Cys Gly Gln Leu Gln Cys Gln Thr Gly Arg Thr Gln Pro Leu Leu 
            580                 585                 590         


Gly Ser Ile Arg Asp Leu Leu Trp Glu Thr Ile Asp Val Asn Gly Thr 
        595                 600                 605             


Glu Leu Asn Cys Ser Trp Val His Leu Asp Leu Gly Ser Asp Val Ala 
    610                 615                 620                 


Gln Pro Leu Leu Thr Leu Pro Gly Thr Ala Cys Gly Pro Gly Leu Val 
625                 630                 635                 640 


Cys Ile Asp His Arg Cys Gln Arg Val Asp Leu Leu Gly Ala Gln Glu 
                645                 650                 655     


Cys Arg Ser Lys Cys His Gly His Gly Val Cys Asp Ser Asn Arg His 
            660                 665                 670         


Cys Tyr Cys Glu Glu Gly Trp Ala Pro Pro Asp Cys Thr Thr Gln Leu 
        675                 680                 685             


Lys Ala Thr Ser Ser Leu Thr Thr Gly Leu Leu Leu Ser Leu Leu Val 
    690                 695                 700                 


Leu Leu Val Leu Val Met Leu Gly Ala Ser Tyr Trp Tyr Arg Ala Arg 
705                 710                 715                 720 


Leu His Gln Arg Leu Cys Gln Leu Lys Gly Pro Thr Cys Gln Tyr Arg 
                725                 730                 735     


Ala Ala Gln Ser Gly Pro Ser Glu Arg Pro Gly Pro Pro Gln Arg Ala 
            740                 745                 750         


Leu Leu Ala Arg Gly Thr Lys Ser Gln Gly Pro Ala Lys Pro Pro Pro 
        755                 760                 765             


Pro Arg Lys Pro Leu Pro Ala Asp Pro Gln Gly Arg Cys Pro Ser Gly 
    770                 775                 780                 


Asp Leu Pro Gly Pro Gly Ala Gly Ile Pro Pro Leu Val Val Pro Ser 
785                 790                 795                 800 


Arg Pro Ala Pro Pro Pro Pro Thr Val Ser Ser Leu Tyr Leu 
                805                 810                 


<210>  243
<211>  796
<212>  PRT
<213>  Homo Sapiens

<400>  243

Met Arg Leu Ala Leu Leu Trp Ala Leu Gly Leu Leu Gly Ala Gly Ser 
1               5                   10                  15      


Pro Leu Pro Ser Trp Pro Leu Pro Asn Ile Gly Gly Thr Glu Glu Gln 
            20                  25                  30          


Gln Ala Glu Ser Glu Lys Ala Pro Arg Glu Pro Leu Glu Pro Gln Val 
        35                  40                  45              


Leu Gln Asp Asp Leu Pro Ile Ser Leu Lys Lys Val Leu Gln Thr Ser 
    50                  55                  60                  


Leu Pro Glu Pro Leu Arg Ile Lys Leu Glu Leu Asp Gly Asp Ser His 
65                  70                  75                  80  


Ile Leu Glu Leu Leu Gln Asn Arg Glu Leu Val Pro Gly Arg Pro Thr 
                85                  90                  95      


Leu Val Trp Tyr Gln Pro Asp Gly Thr Arg Val Val Ser Glu Gly His 
            100                 105                 110         


Thr Leu Glu Asn Cys Cys Tyr Gln Gly Arg Val Arg Gly Tyr Ala Gly 
        115                 120                 125             


Ser Trp Val Ser Ile Cys Thr Cys Ser Gly Leu Arg Gly Leu Val Val 
    130                 135                 140                 


Leu Thr Pro Glu Arg Ser Tyr Thr Leu Glu Gln Gly Pro Gly Asp Leu 
145                 150                 155                 160 


Gln Gly Pro Pro Ile Ile Ser Arg Ile Gln Asp Leu His Leu Pro Gly 
                165                 170                 175     


His Thr Cys Ala Leu Ser Trp Arg Glu Ser Val His Thr Gln Lys Pro 
            180                 185                 190         


Pro Glu His Pro Leu Gly Gln Arg His Ile Arg Arg Arg Arg Asp Val 
        195                 200                 205             


Val Thr Glu Thr Lys Thr Val Glu Leu Val Ile Val Ala Asp His Ser 
    210                 215                 220                 


Glu Ala Gln Lys Tyr Arg Asp Phe Gln His Leu Leu Asn Arg Thr Leu 
225                 230                 235                 240 


Glu Val Ala Leu Leu Leu Asp Thr Phe Phe Arg Pro Leu Asn Val Arg 
                245                 250                 255     


Val Ala Leu Val Gly Leu Glu Ala Trp Thr Gln Arg Asp Leu Val Glu 
            260                 265                 270         


Ile Ser Pro Asn Pro Ala Val Thr Leu Glu Asn Phe Leu His Trp Arg 
        275                 280                 285             


Arg Ala His Leu Leu Pro Arg Leu Pro His Asp Ser Ala Gln Leu Val 
    290                 295                 300                 


Thr Gly Thr Ser Phe Ser Gly Pro Thr Val Gly Met Ala Ile Gln Asn 
305                 310                 315                 320 


Ser Ile Cys Ser Pro Asp Phe Ser Gly Gly Val Asn Met Asp His Ser 
                325                 330                 335     


Thr Ser Ile Leu Gly Val Ala Ser Ser Ile Ala His Glu Leu Gly His 
            340                 345                 350         


Ser Leu Gly Leu Asp His Asp Leu Pro Gly Asn Ser Cys Pro Cys Pro 
        355                 360                 365             


Gly Pro Ala Pro Ala Lys Thr Cys Ile Met Glu Ala Ser Thr Asp Phe 
    370                 375                 380                 


Leu Pro Gly Leu Asn Phe Ser Asn Cys Ser Arg Arg Ala Leu Glu Lys 
385                 390                 395                 400 


Ala Leu Leu Asp Gly Met Gly Ser Cys Leu Phe Glu Arg Leu Pro Ser 
                405                 410                 415     


Leu Pro Pro Met Ala Ala Phe Cys Gly Asn Met Phe Val Glu Pro Gly 
            420                 425                 430         


Glu Gln Cys Asp Cys Gly Phe Leu Asp Asp Cys Val Asp Pro Cys Cys 
        435                 440                 445             


Asp Ser Leu Thr Cys Gln Leu Arg Pro Gly Ala Gln Cys Ala Ser Asp 
    450                 455                 460                 


Gly Pro Cys Cys Gln Asn Cys Gln Leu Arg Pro Ser Gly Trp Gln Cys 
465                 470                 475                 480 


Arg Pro Thr Arg Gly Asp Cys Asp Leu Pro Glu Phe Cys Pro Gly Asp 
                485                 490                 495     


Ser Ser Gln Cys Pro Pro Asp Val Ser Leu Gly Asp Gly Glu Pro Cys 
            500                 505                 510         


Ala Gly Gly Gln Ala Val Cys Met His Gly Arg Cys Ala Ser Tyr Ala 
        515                 520                 525             


Gln Gln Cys Gln Ser Leu Trp Gly Pro Gly Ala Gln Pro Ala Ala Pro 
    530                 535                 540                 


Leu Cys Leu Gln Thr Ala Asn Thr Arg Gly Asn Ala Phe Gly Ser Cys 
545                 550                 555                 560 


Gly Arg Asn Pro Ser Gly Ser Tyr Val Ser Cys Thr Pro Arg Asp Ala 
                565                 570                 575     


Ile Cys Gly Gln Leu Gln Cys Gln Thr Gly Arg Thr Gln Pro Leu Leu 
            580                 585                 590         


Gly Ser Ile Arg Asp Leu Leu Trp Glu Thr Ile Asp Val Asn Gly Thr 
        595                 600                 605             


Glu Leu Asn Cys Ser Trp Val His Leu Asp Leu Gly Ser Asp Val Ala 
    610                 615                 620                 


Gln Pro Leu Leu Thr Leu Pro Gly Thr Ala Cys Gly Pro Gly Leu Val 
625                 630                 635                 640 


Cys Ile Asp His Arg Cys Gln Arg Val Asp Leu Leu Gly Ala Gln Glu 
                645                 650                 655     


Cys Arg Ser Lys Cys His Gly His Gly Val Cys Asp Ser Asn Arg His 
            660                 665                 670         


Cys Tyr Cys Glu Glu Gly Trp Ala Pro Pro Asp Cys Thr Thr Gln Leu 
        675                 680                 685             


Lys Ala Thr Ser Ser Leu Thr Thr Gly Leu Leu Leu Ser Leu Leu Val 
    690                 695                 700                 


Leu Leu Val Leu Val Met Leu Gly Ala Ser Tyr Trp Tyr Arg Ala Arg 
705                 710                 715                 720 


Leu His Gln Arg Leu Cys Gln Leu Lys Gly Pro Thr Cys Gln Tyr Arg 
                725                 730                 735     


Leu Val Leu Ser Ala Ser Arg Pro Pro Leu Pro Gly Arg Cys Arg Leu 
            740                 745                 750         


Thr Leu Cys Pro Arg Asp Ser Ser Leu Arg Gly Gln Pro Ser Pro His 
        755                 760                 765             


Pro Gln Gly Ser His Cys Leu Pro Thr Pro Arg Ala Gly Ala His Arg 
    770                 775                 780                 


Val Thr Cys Pro Ala Gln Gly Leu Glu Ser Arg Pro 
785                 790                 795     


<210>  244
<211>  772
<212>  PRT
<213>  Homo Sapiens

<400>  244

Met Arg Leu Ala Leu Leu Trp Ala Leu Gly Leu Leu Gly Ala Gly Ser 
1               5                   10                  15      


Pro Leu Pro Ser Trp Pro Leu Pro Asn Ile Gly Gly Thr Glu Glu Gln 
            20                  25                  30          


Gln Ala Glu Ser Glu Lys Ala Pro Arg Glu Pro Leu Glu Pro Gln Val 
        35                  40                  45              


Leu Gln Asp Asp Leu Pro Ile Ser Leu Lys Lys Val Leu Gln Thr Ser 
    50                  55                  60                  


Leu Pro Glu Pro Leu Arg Ile Lys Leu Glu Leu Asp Gly Asp Ser His 
65                  70                  75                  80  


Ile Leu Glu Leu Leu Gln Asn Arg Glu Leu Val Pro Gly Arg Pro Thr 
                85                  90                  95      


Leu Val Trp Tyr Gln Pro Asp Gly Thr Arg Val Val Ser Glu Gly His 
            100                 105                 110         


Thr Leu Glu Asn Cys Cys Tyr Gln Gly Arg Val Arg Gly Tyr Ala Gly 
        115                 120                 125             


Ser Trp Val Ser Ile Cys Thr Cys Ser Gly Leu Arg Gly Leu Val Val 
    130                 135                 140                 


Leu Thr Pro Glu Arg Ser Tyr Thr Leu Glu Gln Gly Pro Gly Asp Leu 
145                 150                 155                 160 


Gln Gly Pro Pro Ile Ile Ser Arg Ile Gln Asp Leu His Leu Pro Gly 
                165                 170                 175     


His Thr Cys Ala Leu Ser Trp Arg Glu Ser Val His Thr Gln Lys Pro 
            180                 185                 190         


Pro Glu His Pro Leu Gly Gln Arg His Ile Arg Arg Arg Arg Asp Val 
        195                 200                 205             


Val Thr Glu Thr Lys Thr Val Glu Leu Val Ile Val Ala Asp His Ser 
    210                 215                 220                 


Glu Ala Gln Lys Tyr Arg Asp Phe Gln His Leu Leu Asn Arg Thr Leu 
225                 230                 235                 240 


Glu Val Ala Leu Leu Leu Asp Thr Phe Phe Arg Pro Leu Asn Val Arg 
                245                 250                 255     


Val Ala Leu Val Gly Leu Glu Ala Trp Thr Gln Arg Asp Leu Val Glu 
            260                 265                 270         


Ile Ser Pro Asn Pro Ala Val Thr Leu Glu Asn Phe Leu His Trp Arg 
        275                 280                 285             


Arg Ala His Leu Leu Pro Arg Leu Pro His Asp Ser Ala Gln Leu Val 
    290                 295                 300                 


Thr Gly Thr Ser Phe Ser Gly Pro Thr Val Gly Met Ala Ile Gln Asn 
305                 310                 315                 320 


Ser Ile Cys Ser Pro Asp Phe Ser Gly Gly Val Asn Met Asp His Ser 
                325                 330                 335     


Thr Ser Ile Leu Gly Val Ala Ser Ser Ile Ala His Glu Leu Gly His 
            340                 345                 350         


Ser Leu Gly Leu Asp His Asp Leu Pro Gly Asn Ser Cys Pro Cys Pro 
        355                 360                 365             


Gly Pro Ala Pro Ala Lys Thr Cys Ile Met Glu Ala Ser Thr Asp Phe 
    370                 375                 380                 


Leu Pro Gly Leu Asn Phe Ser Asn Cys Ser Arg Arg Ala Leu Glu Lys 
385                 390                 395                 400 


Ala Leu Leu Asp Gly Met Gly Ser Cys Leu Phe Glu Arg Leu Pro Ser 
                405                 410                 415     


Leu Pro Pro Met Ala Ala Phe Cys Gly Asn Met Phe Val Glu Pro Gly 
            420                 425                 430         


Glu Gln Cys Asp Cys Gly Phe Leu Asp Asp Cys Val Asp Pro Cys Cys 
        435                 440                 445             


Asp Ser Leu Thr Cys Gln Leu Arg Pro Gly Ala Gln Cys Ala Ser Asp 
    450                 455                 460                 


Gly Pro Cys Cys Gln Asn Cys Gln Leu Arg Pro Ser Gly Trp Gln Cys 
465                 470                 475                 480 


Arg Pro Thr Arg Gly Asp Cys Asp Leu Pro Glu Phe Cys Pro Gly Asp 
                485                 490                 495     


Ser Ser Gln Cys Pro Pro Asp Val Ser Leu Gly Asp Gly Glu Pro Cys 
            500                 505                 510         


Ala Gly Gly Gln Ala Val Cys Met His Gly Arg Cys Ala Ser Tyr Ala 
        515                 520                 525             


Gln Gln Cys Gln Ser Leu Trp Gly Pro Gly Ala Gln Pro Ala Ala Pro 
    530                 535                 540                 


Leu Cys Leu Gln Thr Ala Asn Thr Arg Gly Asn Ala Phe Gly Ser Cys 
545                 550                 555                 560 


Gly Arg Asn Pro Ser Gly Ser Tyr Val Ser Cys Thr Pro Arg Asp Ala 
                565                 570                 575     


Ile Cys Gly Gln Leu Gln Cys Gln Thr Gly Arg Thr Gln Pro Leu Leu 
            580                 585                 590         


Gly Ser Ile Arg Asp Leu Leu Trp Glu Thr Ile Asp Val Asn Gly Thr 
        595                 600                 605             


Glu Leu Asn Cys Ser Trp Val His Leu Asp Leu Gly Ser Asp Val Ala 
    610                 615                 620                 


Gln Pro Leu Leu Thr Leu Pro Gly Thr Ala Cys Gly Pro Gly Leu Val 
625                 630                 635                 640 


Cys Ile Asp His Arg Cys Gln Arg Val Asp Leu Leu Gly Ala Gln Glu 
                645                 650                 655     


Cys Arg Ser Lys Cys His Gly His Gly Val Cys Asp Ser Asn Arg His 
            660                 665                 670         


Cys Tyr Cys Glu Glu Gly Trp Ala Pro Pro Asp Cys Thr Thr Gln Leu 
        675                 680                 685             


Lys Ala Thr Ser Ser Leu Thr Thr Gly Leu Leu Leu Ser Leu Leu Val 
    690                 695                 700                 


Leu Leu Val Leu Val Met Leu Gly Ala Ser Tyr Trp Tyr Arg Ala Arg 
705                 710                 715                 720 


Leu His Gln Arg Leu Cys Gln Leu Lys Gly Pro Thr Cys Gln Tyr Ser 
                725                 730                 735     


Leu Arg Gly Gln Pro Ser Pro His Pro Gln Gly Ser His Cys Leu Pro 
            740                 745                 750         


Thr Pro Arg Ala Gly Ala His Arg Val Thr Cys Pro Ala Gln Gly Leu 
        755                 760                 765             


Glu Ser Arg Pro 
    770         


<210>  245
<211>  839
<212>  PRT
<213>  Homo Sapiens

<400>  245

Met Arg Leu Ala Leu Leu Trp Ala Leu Gly Leu Leu Gly Ala Gly Ser 
1               5                   10                  15      


Pro Leu Pro Ser Trp Pro Leu Pro Asn Ile Gly Gly Thr Glu Glu Gln 
            20                  25                  30          


Gln Ala Glu Ser Glu Lys Ala Pro Arg Glu Pro Leu Glu Pro Gln Val 
        35                  40                  45              


Leu Gln Asp Asp Leu Pro Ile Ser Leu Lys Lys Val Leu Gln Thr Ser 
    50                  55                  60                  


Leu Pro Glu Pro Leu Arg Ile Lys Leu Glu Leu Asp Gly Asp Ser His 
65                  70                  75                  80  


Ile Leu Glu Leu Leu Gln Asn Arg Glu Leu Val Pro Gly Arg Pro Thr 
                85                  90                  95      


Leu Val Trp Tyr Gln Pro Asp Gly Thr Arg Val Val Ser Glu Gly His 
            100                 105                 110         


Thr Leu Glu Asn Cys Cys Tyr Gln Gly Arg Val Arg Gly Tyr Ala Gly 
        115                 120                 125             


Ser Trp Val Ser Ile Cys Thr Cys Ser Gly Leu Arg Gly Leu Val Val 
    130                 135                 140                 


Leu Thr Pro Glu Arg Ser Tyr Thr Leu Glu Gln Gly Pro Gly Asp Leu 
145                 150                 155                 160 


Gln Gly Pro Pro Ile Ile Ser Arg Ile Gln Asp Leu His Leu Pro Gly 
                165                 170                 175     


His Thr Cys Ala Leu Ser Trp Arg Glu Ser Val His Thr Gln Lys Pro 
            180                 185                 190         


Pro Glu His Pro Leu Gly Gln Arg His Ile Arg Arg Arg Arg Asp Val 
        195                 200                 205             


Val Thr Glu Thr Lys Thr Val Glu Leu Val Ile Val Ala Asp His Ser 
    210                 215                 220                 


Glu Ala Gln Lys Tyr Arg Asp Phe Gln His Leu Leu Asn Arg Thr Leu 
225                 230                 235                 240 


Glu Val Ala Leu Leu Leu Asp Thr Phe Phe Arg Pro Leu Asn Val Arg 
                245                 250                 255     


Val Ala Leu Val Gly Leu Glu Ala Trp Thr Gln Arg Asp Leu Val Glu 
            260                 265                 270         


Ile Ser Pro Asn Pro Ala Val Thr Leu Glu Asn Phe Leu His Trp Arg 
        275                 280                 285             


Arg Ala His Leu Leu Pro Arg Leu Pro His Asp Ser Ala Gln Leu Val 
    290                 295                 300                 


Thr Gly Thr Ser Phe Ser Gly Pro Thr Val Gly Met Ala Ile Gln Asn 
305                 310                 315                 320 


Ser Ile Cys Ser Pro Asp Phe Ser Gly Gly Val Asn Met Asp His Ser 
                325                 330                 335     


Thr Ser Ile Leu Gly Val Ala Ser Ser Ile Ala His Glu Leu Gly His 
            340                 345                 350         


Ser Leu Gly Leu Asp His Asp Leu Pro Gly Asn Ser Cys Pro Cys Pro 
        355                 360                 365             


Gly Pro Ala Pro Ala Lys Thr Cys Ile Met Glu Ala Ser Thr Asp Phe 
    370                 375                 380                 


Leu Pro Gly Leu Asn Phe Ser Asn Cys Ser Arg Arg Ala Leu Glu Lys 
385                 390                 395                 400 


Ala Leu Leu Asp Gly Met Gly Ser Cys Leu Phe Glu Arg Leu Pro Ser 
                405                 410                 415     


Leu Pro Pro Met Ala Ala Phe Cys Gly Asn Met Phe Val Glu Pro Gly 
            420                 425                 430         


Glu Gln Cys Asp Cys Gly Phe Leu Asp Asp Cys Val Asp Pro Cys Cys 
        435                 440                 445             


Asp Ser Leu Thr Cys Gln Leu Arg Pro Gly Ala Gln Cys Ala Ser Asp 
    450                 455                 460                 


Gly Pro Cys Cys Gln Asn Cys Gln Leu Arg Pro Ser Gly Trp Gln Cys 
465                 470                 475                 480 


Arg Pro Thr Arg Gly Asp Cys Asp Leu Pro Glu Phe Cys Pro Gly Asp 
                485                 490                 495     


Ser Ser Gln Cys Pro Pro Asp Val Ser Leu Gly Asp Gly Glu Pro Cys 
            500                 505                 510         


Ala Gly Gly Gln Ala Val Cys Met His Gly Arg Cys Ala Ser Tyr Ala 
        515                 520                 525             


Gln Gln Cys Gln Ser Leu Trp Gly Pro Gly Ala Gln Pro Ala Ala Pro 
    530                 535                 540                 


Leu Cys Leu Gln Thr Ala Asn Thr Arg Gly Asn Ala Phe Gly Ser Cys 
545                 550                 555                 560 


Gly Arg Asn Pro Ser Gly Ser Tyr Val Ser Cys Thr Pro Arg Asp Ala 
                565                 570                 575     


Ile Cys Gly Gln Leu Gln Cys Gln Thr Gly Arg Thr Gln Pro Leu Leu 
            580                 585                 590         


Gly Ser Ile Arg Asp Leu Leu Trp Glu Thr Ile Asp Val Asn Gly Thr 
        595                 600                 605             


Glu Leu Asn Cys Ser Trp Val His Leu Asp Leu Gly Ser Asp Val Ala 
    610                 615                 620                 


Gln Pro Leu Leu Thr Leu Pro Gly Thr Ala Cys Gly Pro Gly Leu Val 
625                 630                 635                 640 


Cys Ile Asp His Arg Cys Gln Arg Val Asp Leu Leu Gly Ala Gln Glu 
                645                 650                 655     


Cys Arg Ser Lys Cys His Gly His Gly Val Cys Asp Ser Asn Arg His 
            660                 665                 670         


Cys Tyr Cys Glu Glu Gly Trp Ala Pro Pro Asp Cys Thr Thr Gln Leu 
        675                 680                 685             


Lys Ala Thr Ser Ser Leu Thr Thr Gly Leu Leu Leu Ser Leu Leu Val 
    690                 695                 700                 


Leu Leu Val Leu Val Met Leu Gly Ala Ser Tyr Trp Tyr Arg Ala Arg 
705                 710                 715                 720 


Leu His Gln Arg Leu Cys Gln Leu Lys Gly Pro Thr Cys Gln Tyr Arg 
                725                 730                 735     


Ala Ala Gln Ser Gly Pro Ser Glu Arg Pro Gly Pro Pro Gln Arg Ala 
            740                 745                 750         


Leu Leu Ala Arg Gly Thr Lys Gln Ala Ser Ala Leu Ser Phe Pro Ala 
        755                 760                 765             


Pro Pro Ser Arg Pro Leu Pro Pro Asp Pro Val Ser Lys Arg Leu Gln 
    770                 775                 780                 


Ser Gln Gly Pro Ala Lys Pro Pro Pro Pro Arg Lys Pro Leu Pro Ala 
785                 790                 795                 800 


Asp Pro Gln Gly Arg Cys Pro Ser Gly Asp Leu Pro Gly Pro Gly Ala 
                805                 810                 815     


Gly Ile Pro Pro Leu Val Val Pro Ser Arg Pro Ala Pro Pro Pro Pro 
            820                 825                 830         


Thr Val Ser Ser Leu Tyr Leu 
        835                 


<210>  246
<211>  838
<212>  PRT
<213>  Homo Sapiens

<400>  246

Met Arg Leu Ala Leu Leu Trp Ala Leu Gly Leu Leu Gly Ala Gly Ser 
1               5                   10                  15      


Pro Leu Pro Ser Trp Pro Leu Pro Asn Ile Gly Gly Thr Glu Glu Gln 
            20                  25                  30          


Gln Ala Glu Ser Glu Lys Ala Pro Arg Glu Pro Leu Glu Pro Gln Val 
        35                  40                  45              


Leu Gln Asp Asp Leu Pro Ile Ser Leu Lys Lys Val Leu Gln Thr Ser 
    50                  55                  60                  


Leu Pro Glu Pro Leu Arg Ile Lys Leu Glu Leu Asp Gly Asp Ser His 
65                  70                  75                  80  


Ile Leu Glu Leu Leu Gln Asn Arg Glu Leu Val Pro Gly Arg Pro Thr 
                85                  90                  95      


Leu Val Trp Tyr Gln Pro Asp Gly Thr Arg Val Val Ser Glu Gly His 
            100                 105                 110         


Thr Leu Glu Asn Cys Cys Tyr Gln Gly Arg Val Arg Gly Tyr Ala Gly 
        115                 120                 125             


Ser Trp Val Ser Ile Cys Thr Cys Ser Gly Leu Arg Gly Leu Val Val 
    130                 135                 140                 


Leu Thr Pro Glu Arg Ser Tyr Thr Leu Glu Gln Gly Pro Gly Asp Leu 
145                 150                 155                 160 


Gln Gly Pro Pro Ile Ile Ser Arg Ile Gln Asp Leu His Leu Pro Gly 
                165                 170                 175     


His Thr Cys Ala Leu Ser Trp Arg Glu Ser Val His Thr Gln Lys Pro 
            180                 185                 190         


Pro Glu His Pro Leu Gly Gln Arg His Ile Arg Arg Arg Arg Asp Val 
        195                 200                 205             


Val Thr Glu Thr Lys Thr Val Glu Leu Val Ile Val Ala Asp His Ser 
    210                 215                 220                 


Glu Ala Gln Lys Tyr Arg Asp Phe Gln His Leu Leu Asn Arg Thr Leu 
225                 230                 235                 240 


Glu Val Ala Leu Leu Leu Asp Thr Phe Phe Arg Pro Leu Asn Val Arg 
                245                 250                 255     


Val Ala Leu Val Gly Leu Glu Ala Trp Thr Gln Arg Asp Leu Val Glu 
            260                 265                 270         


Ile Ser Pro Asn Pro Ala Val Thr Leu Glu Asn Phe Leu His Trp Arg 
        275                 280                 285             


Arg Ala His Leu Leu Pro Arg Leu Pro His Asp Ser Ala Gln Leu Val 
    290                 295                 300                 


Thr Gly Thr Ser Phe Ser Gly Pro Thr Val Gly Met Ala Ile Gln Asn 
305                 310                 315                 320 


Ser Ile Cys Ser Pro Asp Phe Ser Gly Gly Val Asn Met Asp His Ser 
                325                 330                 335     


Thr Ser Ile Leu Gly Val Ala Ser Ser Ile Ala His Glu Leu Gly His 
            340                 345                 350         


Ser Leu Gly Leu Asp His Asp Leu Pro Gly Asn Ser Cys Pro Cys Pro 
        355                 360                 365             


Gly Pro Ala Pro Ala Lys Thr Cys Ile Met Glu Ala Ser Thr Asp Phe 
    370                 375                 380                 


Leu Pro Gly Leu Asn Phe Ser Asn Cys Ser Arg Arg Ala Leu Glu Lys 
385                 390                 395                 400 


Ala Leu Leu Asp Gly Met Gly Ser Cys Leu Phe Glu Arg Leu Pro Ser 
                405                 410                 415     


Leu Pro Pro Met Ala Ala Phe Cys Gly Asn Met Phe Val Glu Pro Gly 
            420                 425                 430         


Glu Gln Cys Asp Cys Gly Phe Leu Asp Asp Cys Val Asp Pro Cys Cys 
        435                 440                 445             


Asp Ser Leu Thr Cys Gln Leu Arg Pro Gly Ala Gln Cys Ala Ser Asp 
    450                 455                 460                 


Gly Pro Cys Cys Gln Asn Cys Gln Leu Arg Pro Ser Gly Trp Gln Cys 
465                 470                 475                 480 


Arg Pro Thr Arg Gly Asp Cys Asp Leu Pro Glu Phe Cys Pro Gly Asp 
                485                 490                 495     


Ser Ser Gln Cys Pro Pro Asp Val Ser Leu Gly Asp Gly Glu Pro Cys 
            500                 505                 510         


Ala Gly Gly Gln Ala Val Cys Met His Gly Arg Cys Ala Ser Tyr Ala 
        515                 520                 525             


Gln Gln Cys Gln Ser Leu Trp Gly Pro Gly Ala Gln Pro Ala Ala Pro 
    530                 535                 540                 


Leu Cys Leu Gln Thr Ala Asn Thr Arg Gly Asn Ala Phe Gly Ser Cys 
545                 550                 555                 560 


Gly Arg Asn Pro Ser Gly Ser Tyr Val Ser Cys Thr Pro Arg Asp Ala 
                565                 570                 575     


Ile Cys Gly Gln Leu Gln Cys Gln Thr Gly Arg Thr Gln Pro Leu Leu 
            580                 585                 590         


Gly Ser Ile Arg Asp Leu Leu Trp Glu Thr Ile Asp Val Asn Gly Thr 
        595                 600                 605             


Glu Leu Asn Cys Ser Trp Val His Leu Asp Leu Gly Ser Asp Val Ala 
    610                 615                 620                 


Gln Pro Leu Leu Thr Leu Pro Gly Thr Ala Cys Gly Pro Gly Leu Val 
625                 630                 635                 640 


Cys Ile Asp His Arg Cys Gln Arg Val Asp Leu Leu Gly Ala Gln Glu 
                645                 650                 655     


Cys Arg Ser Lys Cys His Gly His Gly Val Cys Asp Ser Asn Arg His 
            660                 665                 670         


Cys Tyr Cys Glu Glu Gly Trp Ala Pro Pro Asp Cys Thr Thr Gln Leu 
        675                 680                 685             


Lys Ala Thr Ser Ser Leu Thr Thr Gly Leu Leu Leu Ser Leu Leu Val 
    690                 695                 700                 


Leu Leu Val Leu Val Met Leu Gly Ala Ser Tyr Trp Tyr Arg Ala Arg 
705                 710                 715                 720 


Leu His Gln Arg Leu Cys Gln Leu Lys Gly Pro Thr Cys Gln Tyr Arg 
                725                 730                 735     


Ala Ala Gln Ser Gly Pro Ser Glu Arg Pro Gly Pro Pro Gln Arg Ala 
            740                 745                 750         


Leu Leu Ala Arg Gly Thr Lys Ala Glu Leu Ala Asp Arg Pro Asn Pro 
        755                 760                 765             


Pro Thr Arg Pro Leu Pro Ala Asp Pro Val Val Arg Ser Pro Lys Ser 
    770                 775                 780                 


Gln Gly Pro Ala Lys Pro Pro Pro Pro Arg Lys Pro Leu Pro Ala Asp 
785                 790                 795                 800 


Pro Gln Gly Arg Cys Pro Ser Gly Asp Leu Pro Gly Pro Gly Ala Gly 
                805                 810                 815     


Ile Pro Pro Leu Val Val Pro Ser Arg Pro Ala Pro Pro Pro Pro Thr 
            820                 825                 830         


Val Ser Ser Leu Tyr Leu 
        835             


<210>  247
<211>  863
<212>  PRT
<213>  Homo Sapiens

<400>  247

Met Arg Leu Ala Leu Leu Trp Ala Leu Gly Leu Leu Gly Ala Gly Ser 
1               5                   10                  15      


Pro Leu Pro Ser Trp Pro Leu Pro Asn Ile Gly Gly Thr Glu Glu Gln 
            20                  25                  30          


Gln Ala Glu Ser Glu Lys Ala Pro Arg Glu Pro Leu Glu Pro Gln Val 
        35                  40                  45              


Leu Gln Asp Asp Leu Pro Ile Ser Leu Lys Lys Val Leu Gln Thr Ser 
    50                  55                  60                  


Leu Pro Glu Pro Leu Arg Ile Lys Leu Glu Leu Asp Gly Asp Ser His 
65                  70                  75                  80  


Ile Leu Glu Leu Leu Gln Asn Arg Glu Leu Val Pro Gly Arg Pro Thr 
                85                  90                  95      


Leu Val Trp Tyr Gln Pro Asp Gly Thr Arg Val Val Ser Glu Gly His 
            100                 105                 110         


Thr Leu Glu Asn Cys Cys Tyr Gln Gly Arg Val Arg Gly Tyr Ala Gly 
        115                 120                 125             


Ser Trp Val Ser Ile Cys Thr Cys Ser Gly Leu Arg Gly Leu Val Val 
    130                 135                 140                 


Leu Thr Pro Glu Arg Ser Tyr Thr Leu Glu Gln Gly Pro Gly Asp Leu 
145                 150                 155                 160 


Gln Gly Pro Pro Ile Ile Ser Arg Ile Gln Asp Leu His Leu Pro Gly 
                165                 170                 175     


His Thr Cys Ala Leu Ser Trp Arg Glu Ser Val His Thr Gln Lys Pro 
            180                 185                 190         


Pro Glu His Pro Leu Gly Gln Arg His Ile Arg Arg Arg Arg Asp Val 
        195                 200                 205             


Val Thr Glu Thr Lys Thr Val Glu Leu Val Ile Val Ala Asp His Ser 
    210                 215                 220                 


Glu Ala Gln Lys Tyr Arg Asp Phe Gln His Leu Leu Asn Arg Thr Leu 
225                 230                 235                 240 


Glu Val Ala Leu Leu Leu Asp Thr Phe Phe Arg Pro Leu Asn Val Arg 
                245                 250                 255     


Val Ala Leu Val Gly Leu Glu Ala Trp Thr Gln Arg Asp Leu Val Glu 
            260                 265                 270         


Ile Ser Pro Asn Pro Ala Val Thr Leu Glu Asn Phe Leu His Trp Arg 
        275                 280                 285             


Arg Ala His Leu Leu Pro Arg Leu Pro His Asp Ser Ala Gln Leu Val 
    290                 295                 300                 


Thr Gly Thr Ser Phe Ser Gly Pro Thr Val Gly Met Ala Ile Gln Asn 
305                 310                 315                 320 


Ser Ile Cys Ser Pro Asp Phe Ser Gly Gly Val Asn Met Asp His Ser 
                325                 330                 335     


Thr Ser Ile Leu Gly Val Ala Ser Ser Ile Ala His Glu Leu Gly His 
            340                 345                 350         


Ser Leu Gly Leu Asp His Asp Leu Pro Gly Asn Ser Cys Pro Cys Pro 
        355                 360                 365             


Gly Pro Ala Pro Ala Lys Thr Cys Ile Met Glu Ala Ser Thr Asp Phe 
    370                 375                 380                 


Leu Pro Gly Leu Asn Phe Ser Asn Cys Ser Arg Arg Ala Leu Glu Lys 
385                 390                 395                 400 


Ala Leu Leu Asp Gly Met Gly Ser Cys Leu Phe Glu Arg Leu Pro Ser 
                405                 410                 415     


Leu Pro Pro Met Ala Ala Phe Cys Gly Asn Met Phe Val Glu Pro Gly 
            420                 425                 430         


Glu Gln Cys Asp Cys Gly Phe Leu Asp Asp Cys Val Asp Pro Cys Cys 
        435                 440                 445             


Asp Ser Leu Thr Cys Gln Leu Arg Pro Gly Ala Gln Cys Ala Ser Asp 
    450                 455                 460                 


Gly Pro Cys Cys Gln Asn Cys Gln Leu Arg Pro Ser Gly Trp Gln Cys 
465                 470                 475                 480 


Arg Pro Thr Arg Gly Asp Cys Asp Leu Pro Glu Phe Cys Pro Gly Asp 
                485                 490                 495     


Ser Ser Gln Cys Pro Pro Asp Val Ser Leu Gly Asp Gly Glu Pro Cys 
            500                 505                 510         


Ala Gly Gly Gln Ala Val Cys Met His Gly Arg Cys Ala Ser Tyr Ala 
        515                 520                 525             


Gln Gln Cys Gln Ser Leu Trp Gly Pro Gly Ala Gln Pro Ala Ala Pro 
    530                 535                 540                 


Leu Cys Leu Gln Thr Ala Asn Thr Arg Gly Asn Ala Phe Gly Ser Cys 
545                 550                 555                 560 


Gly Arg Asn Pro Ser Gly Ser Tyr Val Ser Cys Thr Pro Arg Asp Ala 
                565                 570                 575     


Ile Cys Gly Gln Leu Gln Cys Gln Thr Gly Arg Thr Gln Pro Leu Leu 
            580                 585                 590         


Gly Ser Ile Arg Asp Leu Leu Trp Glu Thr Ile Asp Val Asn Gly Thr 
        595                 600                 605             


Glu Leu Asn Cys Ser Trp Val His Leu Asp Leu Gly Ser Asp Val Ala 
    610                 615                 620                 


Gln Pro Leu Leu Thr Leu Pro Gly Thr Ala Cys Gly Pro Gly Leu Val 
625                 630                 635                 640 


Cys Ile Asp His Arg Cys Gln Arg Val Asp Leu Leu Gly Ala Gln Glu 
                645                 650                 655     


Cys Arg Ser Lys Cys His Gly His Gly Val Cys Asp Ser Asn Arg His 
            660                 665                 670         


Cys Tyr Cys Glu Glu Gly Trp Ala Pro Pro Asp Cys Thr Thr Gln Leu 
        675                 680                 685             


Lys Ala Thr Ser Ser Leu Thr Thr Gly Leu Leu Leu Ser Leu Leu Val 
    690                 695                 700                 


Leu Leu Val Leu Val Met Leu Gly Ala Ser Tyr Trp Tyr Arg Ala Arg 
705                 710                 715                 720 


Leu His Gln Arg Leu Cys Gln Leu Lys Gly Pro Thr Cys Gln Tyr Arg 
                725                 730                 735     


Ala Ala Gln Ser Gly Pro Ser Glu Arg Pro Gly Pro Pro Gln Arg Ala 
            740                 745                 750         


Leu Leu Ala Arg Gly Thr Lys Gln Ala Ser Ala Leu Ser Phe Pro Ala 
        755                 760                 765             


Pro Pro Ser Arg Pro Leu Pro Pro Asp Pro Val Ser Lys Arg Leu Gln 
    770                 775                 780                 


Ala Glu Leu Ala Asp Arg Pro Asn Pro Pro Thr Arg Pro Leu Pro Ala 
785                 790                 795                 800 


Asp Pro Val Val Arg Ser Pro Lys Ser Gln Gly Pro Ala Lys Pro Pro 
                805                 810                 815     


Pro Pro Arg Lys Pro Leu Pro Ala Asp Pro Gln Gly Arg Cys Pro Ser 
            820                 825                 830         


Gly Asp Leu Pro Gly Pro Gly Ala Gly Ile Pro Pro Leu Val Val Pro 
        835                 840                 845             


Ser Arg Pro Ala Pro Pro Pro Pro Thr Val Ser Ser Leu Tyr Leu 
    850                 855                 860             


<210>  248
<211>  862
<212>  PRT
<213>  Homo Sapiens

<400>  248

Met Arg Leu Ala Leu Leu Trp Ala Leu Gly Leu Leu Gly Ala Gly Ser 
1               5                   10                  15      


Pro Leu Pro Ser Trp Pro Leu Pro Asn Ile Gly Gly Thr Glu Glu Gln 
            20                  25                  30          


Gln Ala Glu Ser Glu Lys Ala Pro Arg Glu Pro Leu Glu Pro Gln Val 
        35                  40                  45              


Leu Gln Asp Asp Leu Pro Ile Ser Leu Lys Lys Val Leu Gln Thr Ser 
    50                  55                  60                  


Leu Pro Glu Pro Leu Arg Ile Lys Leu Glu Leu Asp Gly Asp Ser His 
65                  70                  75                  80  


Ile Leu Glu Leu Leu Gln Asn Arg Glu Leu Val Pro Gly Arg Pro Thr 
                85                  90                  95      


Leu Val Trp Tyr Gln Pro Asp Gly Thr Arg Val Val Ser Glu Gly His 
            100                 105                 110         


Thr Leu Glu Asn Cys Cys Tyr Gln Gly Arg Val Arg Gly Tyr Ala Gly 
        115                 120                 125             


Ser Trp Val Ser Ile Cys Thr Cys Ser Gly Leu Arg Gly Leu Val Val 
    130                 135                 140                 


Leu Thr Pro Glu Arg Ser Tyr Thr Leu Glu Gln Gly Pro Gly Asp Leu 
145                 150                 155                 160 


Gln Gly Pro Pro Ile Ile Ser Arg Ile Gln Asp Leu His Leu Pro Gly 
                165                 170                 175     


His Thr Cys Ala Leu Ser Trp Arg Glu Ser Val His Thr Gln Lys Pro 
            180                 185                 190         


Pro Glu His Pro Leu Gly Gln Arg His Ile Arg Arg Arg Arg Asp Val 
        195                 200                 205             


Val Thr Glu Thr Lys Thr Val Glu Leu Val Ile Val Ala Asp His Ser 
    210                 215                 220                 


Glu Ala Gln Lys Tyr Arg Asp Phe Gln His Leu Leu Asn Arg Thr Leu 
225                 230                 235                 240 


Glu Val Ala Leu Leu Leu Asp Thr Phe Phe Arg Pro Leu Asn Val Arg 
                245                 250                 255     


Val Ala Leu Val Gly Leu Glu Ala Trp Thr Gln Arg Asp Leu Val Glu 
            260                 265                 270         


Ile Ser Pro Asn Pro Ala Val Thr Leu Glu Asn Phe Leu His Trp Arg 
        275                 280                 285             


Arg Ala His Leu Leu Pro Arg Leu Pro His Asp Ser Ala Gln Leu Val 
    290                 295                 300                 


Thr Gly Thr Ser Phe Ser Gly Pro Thr Val Gly Met Ala Ile Gln Asn 
305                 310                 315                 320 


Ser Ile Cys Ser Pro Asp Phe Ser Gly Gly Val Asn Met Asp His Ser 
                325                 330                 335     


Thr Ser Ile Leu Gly Val Ala Ser Ser Ile Ala His Glu Leu Gly His 
            340                 345                 350         


Ser Leu Gly Leu Asp His Asp Leu Pro Gly Asn Ser Cys Pro Cys Pro 
        355                 360                 365             


Gly Pro Ala Pro Ala Lys Thr Cys Ile Met Glu Ala Ser Thr Asp Phe 
    370                 375                 380                 


Leu Pro Gly Leu Asn Phe Ser Asn Cys Ser Arg Arg Ala Leu Glu Lys 
385                 390                 395                 400 


Ala Leu Leu Asp Gly Met Gly Ser Cys Leu Phe Glu Arg Leu Pro Ser 
                405                 410                 415     


Leu Pro Pro Met Ala Ala Phe Cys Gly Asn Met Phe Val Glu Pro Gly 
            420                 425                 430         


Glu Gln Cys Asp Cys Gly Phe Leu Asp Asp Cys Val Asp Pro Cys Cys 
        435                 440                 445             


Asp Ser Leu Thr Cys Gln Leu Arg Pro Gly Ala Gln Cys Ala Ser Asp 
    450                 455                 460                 


Gly Pro Cys Cys Gln Asn Cys Gln Leu Arg Pro Ser Gly Trp Gln Cys 
465                 470                 475                 480 


Arg Pro Thr Arg Gly Asp Cys Asp Leu Pro Glu Phe Cys Pro Gly Asp 
                485                 490                 495     


Ser Ser Gln Cys Pro Pro Asp Val Ser Leu Gly Asp Gly Glu Pro Cys 
            500                 505                 510         


Ala Gly Gly Gln Ala Val Cys Met His Gly Arg Cys Ala Ser Tyr Ala 
        515                 520                 525             


Gln Gln Cys Gln Ser Leu Trp Gly Pro Gly Ala Gln Pro Ala Ala Pro 
    530                 535                 540                 


Leu Cys Leu Gln Thr Ala Asn Thr Arg Gly Asn Ala Phe Gly Ser Cys 
545                 550                 555                 560 


Gly Arg Asn Pro Ser Gly Ser Tyr Val Ser Cys Thr Pro Arg Asp Ala 
                565                 570                 575     


Ile Cys Gly Gln Leu Gln Cys Gln Thr Gly Arg Thr Gln Pro Leu Leu 
            580                 585                 590         


Gly Ser Ile Arg Asp Leu Leu Trp Glu Thr Ile Asp Val Asn Gly Thr 
        595                 600                 605             


Glu Leu Asn Cys Ser Trp Val His Leu Asp Leu Gly Ser Asp Val Ala 
    610                 615                 620                 


Gln Pro Leu Leu Thr Leu Pro Gly Thr Ala Cys Gly Pro Gly Leu Val 
625                 630                 635                 640 


Cys Ile Asp His Arg Cys Gln Arg Val Asp Leu Leu Gly Ala Gln Glu 
                645                 650                 655     


Cys Arg Ser Lys Cys His Gly His Gly Val Cys Asp Ser Asn Arg His 
            660                 665                 670         


Cys Tyr Cys Glu Glu Gly Trp Ala Pro Pro Asp Cys Thr Thr Gln Leu 
        675                 680                 685             


Lys Ala Thr Ser Ser Leu Thr Thr Gly Leu Leu Leu Ser Leu Leu Val 
    690                 695                 700                 


Leu Leu Val Leu Val Met Leu Gly Ala Ser Tyr Trp Tyr Arg Ala Arg 
705                 710                 715                 720 


Leu His Gln Arg Leu Cys Gln Leu Lys Gly Pro Thr Cys Gln Tyr Arg 
                725                 730                 735     


Ala Ala Gln Ser Gly Pro Ser Glu Arg Pro Gly Pro Pro Gln Arg Ala 
            740                 745                 750         


Leu Leu Ala Arg Gly Thr Lys Ala Ser Ala Leu Ser Phe Pro Ala Pro 
        755                 760                 765             


Pro Ser Arg Pro Leu Pro Pro Asp Pro Val Ser Lys Arg Leu Gln Ala 
    770                 775                 780                 


Glu Leu Ala Asp Arg Pro Asn Pro Pro Thr Arg Pro Leu Pro Ala Asp 
785                 790                 795                 800 


Pro Val Val Arg Ser Pro Lys Ser Gln Gly Pro Ala Lys Pro Pro Pro 
                805                 810                 815     


Pro Arg Lys Pro Leu Pro Ala Asp Pro Gln Gly Arg Cys Pro Ser Gly 
            820                 825                 830         


Asp Leu Pro Gly Pro Gly Ala Gly Ile Pro Pro Leu Val Val Pro Ser 
        835                 840                 845             


Arg Pro Ala Pro Pro Pro Pro Thr Val Ser Ser Leu Tyr Leu 
    850                 855                 860         


<210>  249
<211>  797
<212>  PRT
<213>  Homo Sapiens

<400>  249

Met Arg Leu Ala Leu Leu Trp Ala Leu Gly Leu Leu Gly Ala Gly Ser 
1               5                   10                  15      


Pro Leu Pro Ser Trp Pro Leu Pro Asn Ile Gly Gly Thr Glu Glu Gln 
            20                  25                  30          


Gln Ala Glu Ser Glu Lys Ala Pro Arg Glu Pro Leu Glu Pro Gln Val 
        35                  40                  45              


Leu Gln Asp Asp Leu Pro Ile Ser Leu Lys Lys Val Leu Gln Thr Ser 
    50                  55                  60                  


Leu Pro Glu Pro Leu Arg Ile Lys Leu Glu Leu Asp Gly Asp Ser His 
65                  70                  75                  80  


Ile Leu Glu Leu Leu Gln Asn Arg Glu Leu Val Pro Gly Arg Pro Thr 
                85                  90                  95      


Leu Val Trp Tyr Gln Pro Asp Gly Thr Arg Val Val Ser Glu Gly His 
            100                 105                 110         


Thr Leu Glu Asn Cys Cys Tyr Gln Gly Arg Val Arg Gly Tyr Ala Gly 
        115                 120                 125             


Ser Trp Val Ser Ile Cys Thr Cys Ser Gly Leu Arg Gly Leu Val Val 
    130                 135                 140                 


Leu Thr Pro Glu Arg Ser Tyr Thr Leu Glu Gln Gly Pro Gly Asp Leu 
145                 150                 155                 160 


Gln Gly Pro Pro Ile Ile Ser Arg Ile Gln Asp Leu His Leu Pro Gly 
                165                 170                 175     


His Thr Cys Ala Leu Ser Trp Arg Glu Ser Val His Thr Gln Lys Pro 
            180                 185                 190         


Pro Glu His Pro Leu Gly Gln Arg His Ile Arg Arg Arg Arg Asp Val 
        195                 200                 205             


Val Thr Glu Thr Lys Thr Val Glu Leu Val Ile Val Ala Asp His Ser 
    210                 215                 220                 


Glu Ala Gln Lys Tyr Arg Asp Phe Gln His Leu Leu Asn Arg Thr Leu 
225                 230                 235                 240 


Glu Val Ala Leu Leu Leu Asp Thr Phe Phe Arg Pro Leu Asn Val Arg 
                245                 250                 255     


Val Ala Leu Val Gly Leu Glu Ala Trp Thr Gln Arg Asp Leu Val Glu 
            260                 265                 270         


Ile Ser Pro Asn Pro Ala Val Thr Leu Glu Asn Phe Leu His Trp Arg 
        275                 280                 285             


Arg Ala His Leu Leu Pro Arg Leu Pro His Asp Ser Ala Gln Leu Val 
    290                 295                 300                 


Thr Gly Thr Ser Phe Ser Gly Pro Thr Val Gly Met Ala Ile Gln Asn 
305                 310                 315                 320 


Ser Ile Cys Ser Pro Asp Phe Ser Gly Gly Val Asn Met Asp His Ser 
                325                 330                 335     


Thr Ser Ile Leu Gly Val Ala Ser Ser Ile Ala His Glu Leu Gly His 
            340                 345                 350         


Ser Leu Gly Leu Asp His Asp Leu Pro Gly Asn Ser Cys Pro Cys Pro 
        355                 360                 365             


Gly Pro Ala Pro Ala Lys Thr Cys Ile Met Glu Ala Ser Thr Asp Phe 
    370                 375                 380                 


Leu Pro Gly Leu Asn Phe Ser Asn Cys Ser Arg Arg Ala Leu Glu Lys 
385                 390                 395                 400 


Ala Leu Leu Asp Gly Met Gly Ser Cys Leu Phe Glu Arg Leu Pro Ser 
                405                 410                 415     


Leu Pro Pro Met Ala Ala Phe Cys Gly Asn Met Phe Val Glu Pro Gly 
            420                 425                 430         


Glu Gln Cys Asp Cys Gly Phe Leu Asp Asp Cys Val Asp Pro Cys Cys 
        435                 440                 445             


Asp Ser Leu Thr Cys Gln Leu Arg Pro Gly Ala Gln Cys Ala Ser Asp 
    450                 455                 460                 


Gly Pro Cys Cys Gln Asn Cys Gln Leu Arg Pro Ser Gly Trp Gln Cys 
465                 470                 475                 480 


Arg Pro Thr Arg Gly Asp Cys Asp Leu Pro Glu Phe Cys Pro Gly Asp 
                485                 490                 495     


Ser Ser Gln Cys Pro Pro Asp Val Ser Leu Gly Asp Gly Glu Pro Cys 
            500                 505                 510         


Ala Gly Gly Gln Ala Val Cys Met His Gly Arg Cys Ala Ser Tyr Ala 
        515                 520                 525             


Gln Gln Cys Gln Ser Leu Trp Gly Pro Gly Ala Gln Pro Ala Ala Pro 
    530                 535                 540                 


Leu Cys Leu Gln Thr Ala Asn Thr Arg Gly Asn Ala Phe Gly Ser Cys 
545                 550                 555                 560 


Gly Arg Asn Pro Ser Gly Ser Tyr Val Ser Cys Thr Pro Arg Asp Ala 
                565                 570                 575     


Ile Cys Gly Gln Leu Gln Cys Gln Thr Gly Arg Thr Gln Pro Leu Leu 
            580                 585                 590         


Gly Ser Ile Arg Asp Leu Leu Trp Glu Thr Ile Asp Val Asn Gly Thr 
        595                 600                 605             


Glu Leu Asn Cys Ser Trp Val His Leu Asp Leu Gly Ser Asp Val Ala 
    610                 615                 620                 


Gln Pro Leu Leu Thr Leu Pro Gly Thr Ala Cys Gly Pro Gly Leu Val 
625                 630                 635                 640 


Cys Ile Asp His Arg Cys Gln Arg Val Asp Leu Leu Gly Ala Gln Glu 
                645                 650                 655     


Cys Arg Ser Lys Cys His Gly His Gly Val Cys Asp Ser Asn Arg His 
            660                 665                 670         


Cys Tyr Cys Glu Glu Gly Trp Ala Pro Pro Asp Cys Thr Thr Gln Leu 
        675                 680                 685             


Lys Ala Thr Ser Ser Leu Thr Thr Gly Leu Leu Leu Ser Leu Leu Val 
    690                 695                 700                 


Leu Leu Val Leu Val Met Leu Gly Ala Ser Tyr Trp Tyr Arg Ala Arg 
705                 710                 715                 720 


Leu His Gln Arg Leu Cys Gln Leu Lys Gly Pro Thr Cys Gln Tyr Arg 
                725                 730                 735     


Ala Ala Gln Ser Gly Pro Ser Glu Arg Pro Gly Pro Pro Gln Arg Ala 
            740                 745                 750         


Leu Leu Ala Arg Gly Thr Lys Ala Glu Leu Ala Asp Arg Pro Asn Pro 
        755                 760                 765             


Pro Thr Arg Pro Leu Pro Ala Asp Pro Val Val Arg Ser Pro Lys Val 
    770                 775                 780                 


Thr Val Gly Gly Glu Lys Gly Thr Ala Ser Pro Pro Thr 
785                 790                 795         


<210>  250
<211>  822
<212>  PRT
<213>  Homo Sapiens

<400>  250

Met Arg Leu Ala Leu Leu Trp Ala Leu Gly Leu Leu Gly Ala Gly Ser 
1               5                   10                  15      


Pro Leu Pro Ser Trp Pro Leu Pro Asn Ile Gly Gly Thr Glu Glu Gln 
            20                  25                  30          


Gln Ala Glu Ser Glu Lys Ala Pro Arg Glu Pro Leu Glu Pro Gln Val 
        35                  40                  45              


Leu Gln Asp Asp Leu Pro Ile Ser Leu Lys Lys Val Leu Gln Thr Ser 
    50                  55                  60                  


Leu Pro Glu Pro Leu Arg Ile Lys Leu Glu Leu Asp Gly Asp Ser His 
65                  70                  75                  80  


Ile Leu Glu Leu Leu Gln Asn Arg Glu Leu Val Pro Gly Arg Pro Thr 
                85                  90                  95      


Leu Val Trp Tyr Gln Pro Asp Gly Thr Arg Val Val Ser Glu Gly His 
            100                 105                 110         


Thr Leu Glu Asn Cys Cys Tyr Gln Gly Arg Val Arg Gly Tyr Ala Gly 
        115                 120                 125             


Ser Trp Val Ser Ile Cys Thr Cys Ser Gly Leu Arg Gly Leu Val Val 
    130                 135                 140                 


Leu Thr Pro Glu Arg Ser Tyr Thr Leu Glu Gln Gly Pro Gly Asp Leu 
145                 150                 155                 160 


Gln Gly Pro Pro Ile Ile Ser Arg Ile Gln Asp Leu His Leu Pro Gly 
                165                 170                 175     


His Thr Cys Ala Leu Ser Trp Arg Glu Ser Val His Thr Gln Lys Pro 
            180                 185                 190         


Pro Glu His Pro Leu Gly Gln Arg His Ile Arg Arg Arg Arg Asp Val 
        195                 200                 205             


Val Thr Glu Thr Lys Thr Val Glu Leu Val Ile Val Ala Asp His Ser 
    210                 215                 220                 


Glu Ala Gln Lys Tyr Arg Asp Phe Gln His Leu Leu Asn Arg Thr Leu 
225                 230                 235                 240 


Glu Val Ala Leu Leu Leu Asp Thr Phe Phe Arg Pro Leu Asn Val Arg 
                245                 250                 255     


Val Ala Leu Val Gly Leu Glu Ala Trp Thr Gln Arg Asp Leu Val Glu 
            260                 265                 270         


Ile Ser Pro Asn Pro Ala Val Thr Leu Glu Asn Phe Leu His Trp Arg 
        275                 280                 285             


Arg Ala His Leu Leu Pro Arg Leu Pro His Asp Ser Ala Gln Leu Val 
    290                 295                 300                 


Thr Gly Thr Ser Phe Ser Gly Pro Thr Val Gly Met Ala Ile Gln Asn 
305                 310                 315                 320 


Ser Ile Cys Ser Pro Asp Phe Ser Gly Gly Val Asn Met Asp His Ser 
                325                 330                 335     


Thr Ser Ile Leu Gly Val Ala Ser Ser Ile Ala His Glu Leu Gly His 
            340                 345                 350         


Ser Leu Gly Leu Asp His Asp Leu Pro Gly Asn Ser Cys Pro Cys Pro 
        355                 360                 365             


Gly Pro Ala Pro Ala Lys Thr Cys Ile Met Glu Ala Ser Thr Asp Phe 
    370                 375                 380                 


Leu Pro Gly Leu Asn Phe Ser Asn Cys Ser Arg Arg Ala Leu Glu Lys 
385                 390                 395                 400 


Ala Leu Leu Asp Gly Met Gly Ser Cys Leu Phe Glu Arg Leu Pro Ser 
                405                 410                 415     


Leu Pro Pro Met Ala Ala Phe Cys Gly Asn Met Phe Val Glu Pro Gly 
            420                 425                 430         


Glu Gln Cys Asp Cys Gly Phe Leu Asp Asp Cys Val Asp Pro Cys Cys 
        435                 440                 445             


Asp Ser Leu Thr Cys Gln Leu Arg Pro Gly Ala Gln Cys Ala Ser Asp 
    450                 455                 460                 


Gly Pro Cys Cys Gln Asn Cys Gln Leu Arg Pro Ser Gly Trp Gln Cys 
465                 470                 475                 480 


Arg Pro Thr Arg Gly Asp Cys Asp Leu Pro Glu Phe Cys Pro Gly Asp 
                485                 490                 495     


Ser Ser Gln Cys Pro Pro Asp Val Ser Leu Gly Asp Gly Glu Pro Cys 
            500                 505                 510         


Ala Gly Gly Gln Ala Val Cys Met His Gly Arg Cys Ala Ser Tyr Ala 
        515                 520                 525             


Gln Gln Cys Gln Ser Leu Trp Gly Pro Gly Ala Gln Pro Ala Ala Pro 
    530                 535                 540                 


Leu Cys Leu Gln Thr Ala Asn Thr Arg Gly Asn Ala Phe Gly Ser Cys 
545                 550                 555                 560 


Gly Arg Asn Pro Ser Gly Ser Tyr Val Ser Cys Thr Pro Arg Asp Ala 
                565                 570                 575     


Ile Cys Gly Gln Leu Gln Cys Gln Thr Gly Arg Thr Gln Pro Leu Leu 
            580                 585                 590         


Gly Ser Ile Arg Asp Leu Leu Trp Glu Thr Ile Asp Val Asn Gly Thr 
        595                 600                 605             


Glu Leu Asn Cys Ser Trp Val His Leu Asp Leu Gly Ser Asp Val Ala 
    610                 615                 620                 


Gln Pro Leu Leu Thr Leu Pro Gly Thr Ala Cys Gly Pro Gly Leu Val 
625                 630                 635                 640 


Cys Ile Asp His Arg Cys Gln Arg Val Asp Leu Leu Gly Ala Gln Glu 
                645                 650                 655     


Cys Arg Ser Lys Cys His Gly His Gly Val Cys Asp Ser Asn Arg His 
            660                 665                 670         


Cys Tyr Cys Glu Glu Gly Trp Ala Pro Pro Asp Cys Thr Thr Gln Leu 
        675                 680                 685             


Lys Ala Thr Ser Ser Leu Thr Thr Gly Leu Leu Leu Ser Leu Leu Val 
    690                 695                 700                 


Leu Leu Val Leu Val Met Leu Gly Ala Ser Tyr Trp Tyr Arg Ala Arg 
705                 710                 715                 720 


Leu His Gln Arg Leu Cys Gln Leu Lys Gly Pro Thr Cys Gln Tyr Arg 
                725                 730                 735     


Ala Ala Gln Ser Gly Pro Ser Glu Arg Pro Gly Pro Pro Gln Arg Ala 
            740                 745                 750         


Leu Leu Ala Arg Gly Thr Lys Gln Ala Ser Ala Leu Ser Phe Pro Ala 
        755                 760                 765             


Pro Pro Ser Arg Pro Leu Pro Pro Asp Pro Val Ser Lys Arg Leu Gln 
    770                 775                 780                 


Ala Glu Leu Ala Asp Arg Pro Asn Pro Pro Thr Arg Pro Leu Pro Ala 
785                 790                 795                 800 


Asp Pro Val Val Arg Ser Pro Lys Val Thr Val Gly Gly Glu Lys Gly 
                805                 810                 815     


Thr Ala Ser Pro Pro Thr 
            820         


<210>  251
<211>  824
<212>  PRT
<213>  Homo Sapiens

<400>  251

Met Arg Leu Ala Leu Leu Trp Ala Leu Gly Leu Leu Gly Ala Gly Ser 
1               5                   10                  15      


Pro Leu Pro Ser Trp Pro Leu Pro Asn Ile Val Leu Ser Trp Gly Val 
            20                  25                  30          


Leu Gly Pro Ala Gly Gly Thr Glu Glu Gln Gln Ala Glu Ser Glu Lys 
        35                  40                  45              


Ala Pro Arg Glu Pro Leu Glu Pro Gln Val Leu Gln Asp Asp Leu Pro 
    50                  55                  60                  


Ile Ser Leu Lys Lys Val Leu Gln Thr Ser Leu Pro Glu Pro Leu Arg 
65                  70                  75                  80  


Ile Lys Leu Glu Leu Asp Gly Asp Ser His Ile Leu Glu Leu Leu Gln 
                85                  90                  95      


Asn Arg Glu Leu Val Pro Gly Arg Pro Thr Leu Val Trp Tyr Gln Pro 
            100                 105                 110         


Asp Gly Thr Arg Val Val Ser Glu Gly His Thr Leu Glu Asn Cys Cys 
        115                 120                 125             


Tyr Gln Gly Arg Val Arg Gly Tyr Ala Gly Ser Trp Val Ser Ile Cys 
    130                 135                 140                 


Thr Cys Ser Gly Leu Arg Gly Leu Val Val Leu Thr Pro Glu Arg Ser 
145                 150                 155                 160 


Tyr Thr Leu Glu Gln Gly Pro Gly Asp Leu Gln Gly Pro Pro Ile Ile 
                165                 170                 175     


Ser Arg Ile Gln Asp Leu His Leu Pro Gly His Thr Cys Ala Leu Ser 
            180                 185                 190         


Trp Arg Glu Ser Val His Thr Gln Lys Pro Pro Glu His Pro Leu Gly 
        195                 200                 205             


Gln Arg His Ile Arg Arg Arg Arg Asp Val Val Thr Glu Thr Lys Thr 
    210                 215                 220                 


Val Glu Leu Val Ile Val Ala Asp His Ser Glu Ala Gln Lys Tyr Arg 
225                 230                 235                 240 


Asp Phe Gln His Leu Leu Asn Arg Thr Leu Glu Val Ala Leu Leu Leu 
                245                 250                 255     


Asp Thr Phe Phe Arg Pro Leu Asn Val Arg Val Ala Leu Val Gly Leu 
            260                 265                 270         


Glu Ala Trp Thr Gln Arg Asp Leu Val Glu Ile Ser Pro Asn Pro Ala 
        275                 280                 285             


Val Thr Leu Glu Asn Phe Leu His Trp Arg Arg Ala His Leu Leu Pro 
    290                 295                 300                 


Arg Leu Pro His Asp Ser Ala Gln Leu Val Thr Gly Thr Ser Phe Ser 
305                 310                 315                 320 


Gly Pro Thr Val Gly Met Ala Ile Gln Asn Ser Ile Cys Ser Pro Asp 
                325                 330                 335     


Phe Ser Gly Gly Val Asn Met Asp His Ser Thr Ser Ile Leu Gly Val 
            340                 345                 350         


Ala Ser Ser Ile Ala His Glu Leu Gly His Ser Leu Gly Leu Asp His 
        355                 360                 365             


Asp Leu Pro Gly Asn Ser Cys Pro Cys Pro Gly Pro Ala Pro Ala Lys 
    370                 375                 380                 


Thr Cys Ile Met Glu Ala Ser Thr Asp Phe Leu Pro Gly Leu Asn Phe 
385                 390                 395                 400 


Ser Asn Cys Ser Arg Arg Ala Leu Glu Lys Ala Leu Leu Asp Gly Met 
                405                 410                 415     


Gly Ser Cys Leu Phe Glu Arg Leu Pro Ser Leu Pro Pro Met Ala Ala 
            420                 425                 430         


Phe Cys Gly Asn Met Phe Val Glu Pro Gly Glu Gln Cys Asp Cys Gly 
        435                 440                 445             


Phe Leu Asp Asp Cys Val Asp Pro Cys Cys Asp Ser Leu Thr Cys Gln 
    450                 455                 460                 


Leu Arg Pro Gly Ala Gln Cys Ala Ser Asp Gly Pro Cys Cys Gln Asn 
465                 470                 475                 480 


Cys Gln Leu Arg Pro Ser Gly Trp Gln Cys Arg Pro Thr Arg Gly Asp 
                485                 490                 495     


Cys Asp Leu Pro Glu Phe Cys Pro Gly Asp Ser Ser Gln Cys Pro Pro 
            500                 505                 510         


Asp Val Ser Leu Gly Asp Gly Glu Pro Cys Ala Gly Gly Gln Ala Val 
        515                 520                 525             


Cys Met His Gly Arg Cys Ala Ser Tyr Ala Gln Gln Cys Gln Ser Leu 
    530                 535                 540                 


Trp Gly Pro Gly Ala Gln Pro Ala Ala Pro Leu Cys Leu Gln Thr Ala 
545                 550                 555                 560 


Asn Thr Arg Gly Asn Ala Phe Gly Ser Cys Gly Arg Asn Pro Ser Gly 
                565                 570                 575     


Ser Tyr Val Ser Cys Thr Pro Arg Asp Ala Ile Cys Gly Gln Leu Gln 
            580                 585                 590         


Cys Gln Thr Gly Arg Thr Gln Pro Leu Leu Gly Ser Ile Arg Asp Leu 
        595                 600                 605             


Leu Trp Glu Thr Ile Asp Val Asn Gly Thr Glu Leu Asn Cys Ser Trp 
    610                 615                 620                 


Val His Leu Asp Leu Gly Ser Asp Val Ala Gln Pro Leu Leu Thr Leu 
625                 630                 635                 640 


Pro Gly Thr Ala Cys Gly Pro Gly Leu Val Cys Ile Asp His Arg Cys 
                645                 650                 655     


Gln Arg Val Asp Leu Leu Gly Ala Gln Glu Cys Arg Ser Lys Cys His 
            660                 665                 670         


Gly His Gly Val Cys Asp Ser Asn Arg His Cys Tyr Cys Glu Glu Gly 
        675                 680                 685             


Trp Ala Pro Pro Asp Cys Thr Thr Gln Leu Lys Ala Thr Ser Ser Leu 
    690                 695                 700                 


Thr Thr Gly Leu Leu Leu Ser Leu Leu Val Leu Leu Val Leu Val Met 
705                 710                 715                 720 


Leu Gly Ala Ser Tyr Trp Tyr Arg Ala Arg Leu His Gln Arg Leu Cys 
                725                 730                 735     


Gln Leu Lys Gly Pro Thr Cys Gln Tyr Arg Ala Ala Gln Ser Gly Pro 
            740                 745                 750         


Ser Glu Arg Pro Gly Pro Pro Gln Arg Ala Leu Leu Ala Arg Gly Thr 
        755                 760                 765             


Lys Ser Gln Gly Pro Ala Lys Pro Pro Pro Pro Arg Lys Pro Leu Pro 
    770                 775                 780                 


Ala Asp Pro Gln Gly Arg Cys Pro Ser Gly Asp Leu Pro Gly Pro Gly 
785                 790                 795                 800 


Ala Gly Ile Pro Pro Leu Val Val Pro Ser Arg Pro Ala Pro Pro Pro 
                805                 810                 815     


Pro Thr Val Ser Ser Leu Tyr Leu 
            820                 


<210>  252
<211>  633
<212>  PRT
<213>  Homo Sapiens

<400>  252

Met Arg Leu Ala Leu Leu Trp Ala Leu Gly Leu Leu Gly Ala Gly Ser 
1               5                   10                  15      


Pro Leu Pro Ser Trp Pro Leu Pro Asn Ile Val Ser Ala Cys Asn Val 
            20                  25                  30          


Glu Ala Pro Gln Val Ala Leu Arg Ser Ser Arg Gln Ser Gln Arg Arg 
        35                  40                  45              


Pro Arg Gly Ser Pro Trp Ser Pro Arg Ser Phe Arg Thr Ile Ser Gln 
    50                  55                  60                  


Leu Ala Ser Lys Arg Cys Phe Arg Glu Leu Val Pro Gly Arg Pro Thr 
65                  70                  75                  80  


Leu Val Trp Tyr Gln Pro Asp Gly Thr Arg Val Val Ser Glu Gly His 
                85                  90                  95      


Thr Leu Glu Asn Cys Cys Tyr Gln Gly Arg Val Arg Gly Tyr Ala Gly 
            100                 105                 110         


Ser Trp Val Ser Ile Cys Thr Cys Ser Gly Leu Arg Gly Leu Val Val 
        115                 120                 125             


Leu Thr Pro Glu Arg Ser Tyr Thr Leu Glu Gln Gly Pro Gly Asp Leu 
    130                 135                 140                 


Gln Gly Pro Pro Ile Ile Ser Arg Ile Gln Asp Leu His Leu Pro Gly 
145                 150                 155                 160 


His Thr Cys Ala Leu Ser Trp Arg Glu Ser Val His Thr Gln Lys Pro 
                165                 170                 175     


Pro Glu His Pro Leu Gly Gln Arg His Ile Arg Arg Arg Arg Asp Val 
            180                 185                 190         


Val Thr Glu Thr Lys Thr Val Glu Leu Val Ile Val Ala Asp His Ser 
        195                 200                 205             


Glu Ala Gln Lys Tyr Arg Asp Phe Gln His Leu Leu Asn Arg Thr Leu 
    210                 215                 220                 


Glu Val Ala Leu Leu Leu Asp Thr Phe Phe Arg Pro Leu Asn Val Arg 
225                 230                 235                 240 


Val Ala Leu Val Gly Leu Glu Ala Trp Thr Gln Arg Asp Leu Val Glu 
                245                 250                 255     


Ile Ser Pro Asn Pro Ala Val Thr Leu Glu Asn Phe Leu His Trp Arg 
            260                 265                 270         


Arg Ala His Leu Leu Pro Arg Leu Pro His Asp Ser Ala Gln Leu Val 
        275                 280                 285             


Thr Gly Thr Ser Phe Ser Gly Pro Thr Val Gly Met Ala Ile Gln Asn 
    290                 295                 300                 


Ser Ile Cys Ser Pro Asp Phe Ser Gly Gly Val Asn Met Asp His Ser 
305                 310                 315                 320 


Thr Ser Ile Leu Gly Val Ala Ser Ser Ile Ala His Glu Leu Gly His 
                325                 330                 335     


Ser Leu Gly Leu Asp His Asp Leu Pro Gly Asn Ser Cys Pro Cys Pro 
            340                 345                 350         


Gly Pro Ala Pro Ala Lys Thr Cys Ile Met Glu Ala Ser Thr Asp Phe 
        355                 360                 365             


Leu Pro Gly Leu Asn Phe Ser Asn Cys Ser Arg Arg Ala Leu Glu Lys 
    370                 375                 380                 


Ala Leu Leu Asp Gly Met Gly Ser Cys Leu Phe Glu Arg Leu Pro Ser 
385                 390                 395                 400 


Leu Pro Pro Met Ala Ala Phe Cys Gly Asn Met Phe Val Glu Pro Gly 
                405                 410                 415     


Glu Gln Cys Asp Cys Gly Phe Leu Asp Asp Cys Val Asp Pro Cys Cys 
            420                 425                 430         


Asp Ser Leu Thr Cys Gln Leu Arg Pro Gly Ala Gln Cys Ala Ser Asp 
        435                 440                 445             


Gly Pro Cys Cys Gln Asn Cys Gln Leu Arg Pro Ser Gly Trp Gln Cys 
    450                 455                 460                 


Arg Pro Thr Arg Gly Asp Cys Asp Leu Pro Glu Phe Cys Pro Gly Asp 
465                 470                 475                 480 


Ser Ser Gln Cys Pro Pro Asp Val Ser Leu Gly Asp Gly Glu Pro Cys 
                485                 490                 495     


Ala Gly Gly Gln Ala Val Cys Met His Gly Arg Cys Ala Ser Tyr Ala 
            500                 505                 510         


Gln Gln Cys Gln Ser Leu Trp Gly Pro Gly Ala Gln Pro Ala Ala Pro 
        515                 520                 525             


Leu Cys Leu Gln Thr Ala Asn Thr Arg Gly Asn Ala Phe Gly Ser Cys 
    530                 535                 540                 


Gly Arg Asn Pro Ser Gly Ser Tyr Val Ser Cys Thr Pro Arg Asp Ala 
545                 550                 555                 560 


Ile Cys Gly Gln Leu Gln Cys Gln Thr Gly Arg Thr Gln Pro Leu Leu 
                565                 570                 575     


Gly Ser Ile Arg Asp Leu Leu Trp Glu Thr Ile Asp Val Asn Gly Thr 
            580                 585                 590         


Glu Leu Asn Cys Ser Trp Val His Leu Asp Leu Gly Ser Asp Val Ala 
        595                 600                 605             


Gln Pro Leu Leu Thr Leu Pro Gly Thr Ala Cys Gly Pro Gly Leu Val 
    610                 615                 620                 


Ser Ser Leu Gly Gly Gln Asp Gln Val 
625                 630             


<210>  253
<211>  824
<212>  PRT
<213>  Homo Sapiens

<400>  253

Met Arg Gln Ser Leu Leu Phe Leu Thr Ser Val Val Pro Phe Val Leu 
1               5                   10                  15      


Ala Pro Arg Pro Pro Asp Asp Pro Gly Phe Gly Pro His Gln Arg Leu 
            20                  25                  30          


Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser 
        35                  40                  45              


Asn Ile Gln Gln His Ser Val Arg Lys Arg Asp Leu Gln Thr Ser Thr 
    50                  55                  60                  


His Val Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys 
65                  70                  75                  80  


Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Phe Lys Val 
                85                  90                  95      


Val Val Val Asp Gly Lys Asn Glu Ser Glu Tyr Thr Val Lys Trp Gln 
            100                 105                 110         


Asp Phe Phe Thr Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu 
        115                 120                 125             


Ala His Ile Arg Asp Asp Asp Val Ile Ile Arg Ile Asn Thr Asp Gly 
    130                 135                 140                 


Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys 
145                 150                 155                 160 


Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asn Val Ser 
                165                 170                 175     


Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Lys Val Asp Asn Glu 
            180                 185                 190         


Glu Leu Leu Pro Lys Gly Leu Val Asp Arg Glu Pro Pro Glu Glu Leu 
        195                 200                 205             


Val His Arg Val Lys Arg Arg Ala Asp Pro Asp Pro Met Lys Asn Thr 
    210                 215                 220                 


Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Arg Tyr Met Gly 
225                 230                 235                 240 


Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp 
                245                 250                 255     


Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe 
            260                 265                 270         


Lys Gly Tyr Gly Ile Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro 
        275                 280                 285             


Gln Glu Val Lys Pro Gly Glu Lys His Tyr Asn Met Ala Lys Ser Tyr 
    290                 295                 300                 


Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln 
305                 310                 315                 320 


Phe Ser Phe Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His 
                325                 330                 335     


Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr 
            340                 345                 350         


Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala 
        355                 360                 365             


Tyr Tyr Ser Pro Val Gly Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu 
    370                 375                 380                 


Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp 
385                 390                 395                 400 


Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp 
                405                 410                 415     


Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys 
            420                 425                 430         


Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys 
        435                 440                 445             


Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser 
    450                 455                 460                 


Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn 
465                 470                 475                 480 


Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu 
                485                 490                 495     


Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Glu Gly Val 
            500                 505                 510         


Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu 
        515                 520                 525             


Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly 
    530                 535                 540                 


Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asn 
545                 550                 555                 560 


Ala Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Asp Gly 
                565                 570                 575     


Lys Cys Ile Pro Phe Cys Glu Arg Glu Gln Gln Leu Glu Ser Cys Ala 
            580                 585                 590         


Cys Asn Glu Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asp Leu Ser 
        595                 600                 605             


Gly Arg Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu 
    610                 615                 620                 


Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys 
625                 630                 635                 640 


Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile 
                645                 650                 655     


Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile 
            660                 665                 670         


Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser 
        675                 680                 685             


Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser 
    690                 695                 700                 


Leu Ser Leu Phe His Pro Ser Asn Val Glu Met Leu Ser Ser Met Asp 
705                 710                 715                 720 


Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro 
                725                 730                 735     


Gly Arg Leu Gln Pro Ala Pro Val Ile Pro Ser Ala Pro Ala Ala Pro 
            740                 745                 750         


Lys Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp Pro Ser Thr 
        755                 760                 765             


Asp Ser His Met Asp Glu Asp Gly Phe Glu Lys Asp Pro Phe Pro Asn 
    770                 775                 780                 


Ser Ser Thr Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp His Pro Val 
785                 790                 795                 800 


Thr Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg Gln Asn Arg 
                805                 810                 815     


Val Asp Ser Lys Glu Thr Glu Cys 
            820                 


<210>  254
<211>  285
<212>  PRT
<213>  Homo Sapiens

<400>  254

Met Arg Gln Ser Leu Leu Phe Leu Thr Ser Val Val Pro Phe Val Leu 
1               5                   10                  15      


Ala Pro Arg Pro Pro Asp Asp Pro Gly Phe Gly Pro His Gln Arg Leu 
            20                  25                  30          


Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser 
        35                  40                  45              


Asn Ile Gln Gln His Ser Val Arg Lys Arg Asp Leu Gln Thr Ser Thr 
    50                  55                  60                  


His Val Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys 
65                  70                  75                  80  


Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Phe Lys Val 
                85                  90                  95      


Val Val Val Asp Gly Lys Asn Glu Ser Glu Tyr Thr Val Lys Trp Gln 
            100                 105                 110         


Asp Phe Phe Thr Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu 
        115                 120                 125             


Ala His Ile Arg Asp Asp Asp Val Ile Ile Arg Ile Asn Thr Asp Gly 
    130                 135                 140                 


Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys 
145                 150                 155                 160 


Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asn Val Ser 
                165                 170                 175     


Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Lys Val Asp Asn Glu 
            180                 185                 190         


Glu Leu Leu Pro Lys Gly Leu Val Asp Arg Glu Pro Pro Glu Glu Leu 
        195                 200                 205             


Val His Arg Val Lys Arg Arg Ala Asp Pro Asp Pro Met Lys Asn Thr 
    210                 215                 220                 


Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Arg Tyr Met Gly 
225                 230                 235                 240 


Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp 
                245                 250                 255     


Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe 
            260                 265                 270         


Lys Gly Tyr Gly Ile Gln Ile Glu Gln Leu Leu Phe Glu 
        275                 280                 285 


<210>  255
<211>  258
<212>  PRT
<213>  Homo Sapiens

<400>  255

Met Arg Gln Ser Leu Leu Phe Leu Thr Ser Val Val Pro Phe Val Leu 
1               5                   10                  15      


Ala Pro Arg Pro Pro Asp Asp Pro Gly Phe Gly Pro His Gln Arg Leu 
            20                  25                  30          


Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser 
        35                  40                  45              


Asn Ile Gln Gln His Ser Val Arg Lys Arg Asp Leu Gln Thr Ser Thr 
    50                  55                  60                  


His Val Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys 
65                  70                  75                  80  


Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Phe Lys Val 
                85                  90                  95      


Val Val Val Asp Gly Lys Asn Glu Ser Glu Tyr Thr Val Lys Trp Gln 
            100                 105                 110         


Asp Phe Phe Thr Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu 
        115                 120                 125             


Ala His Ile Arg Asp Asp Asp Val Ile Ile Arg Ile Asn Thr Asp Gly 
    130                 135                 140                 


Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys 
145                 150                 155                 160 


Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asn Val Ser 
                165                 170                 175     


Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Lys Val Asp Asn Glu 
            180                 185                 190         


Glu Leu Leu Pro Lys Gly Leu Val Asp Arg Glu Pro Pro Glu Glu Leu 
        195                 200                 205             


Val His Arg Val Lys Arg Arg Ala Asp Pro Asp Pro Met Lys Asn Thr 
    210                 215                 220                 


Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Arg Tyr Met Gly 
225                 230                 235                 240 


Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile His Thr Asp Arg 
                245                 250                 255     


Ala Asn 
        


<210>  256
<211>  115
<212>  PRT
<213>  Homo Sapiens

<400>  256

Met Phe Leu Leu Leu Ala Leu Leu Thr Glu Leu Gly Arg Leu Gln Ala 
1               5                   10                  15      


His Glu Gly Ser Glu Gly Ile Phe Leu His Val Thr Val Pro Arg Lys 
            20                  25                  30          


Ile Lys Ser Asn Asp Ser Glu Val Ser Glu Arg Lys Met Ile Tyr Ile 
        35                  40                  45              


Ile Thr Ile Asp Gly Gln Pro Tyr Thr Leu His Leu Gly Lys Gln Ser 
    50                  55                  60                  


Phe Leu Pro Gln Asn Phe Leu Val Tyr Thr Tyr Asn Glu Thr Gly Ser 
65                  70                  75                  80  


Leu His Ser Val Ser Pro Tyr Phe Met Met His Cys His Tyr Gln Gly 
                85                  90                  95      


Tyr Ala Ala Glu Phe Pro Asn Ser Phe Val Thr Leu Ser Ile Cys Ser 
            100                 105                 110         


Gly Leu Arg 
        115 


<210>  257
<211>  715
<212>  PRT
<213>  Homo Sapiens

<400>  257

Met Phe Leu Leu Leu Ala Leu Leu Thr Glu Leu Gly Arg Leu Gln Ala 
1               5                   10                  15      


His Glu Gly Ser Glu Gly Ile Phe Leu His Val Thr Val Pro Arg Lys 
            20                  25                  30          


Ile Lys Ser Asn Asp Ser Glu Val Ser Glu Arg Lys Met Ile Tyr Ile 
        35                  40                  45              


Ile Thr Ile Asp Gly Gln Pro Tyr Thr Leu His Leu Gly Lys Gln Ser 
    50                  55                  60                  


Phe Leu Pro Gln Asn Phe Leu Val Tyr Thr Tyr Asn Glu Thr Gly Ser 
65                  70                  75                  80  


Leu His Ser Val Ser Pro Tyr Phe Met Met His Cys His Tyr Gln Gly 
                85                  90                  95      


Tyr Ala Ala Glu Phe Pro Asn Ser Phe Val Thr Leu Ser Ile Cys Ser 
            100                 105                 110         


Gly Leu Arg Gly Phe Leu Gln Phe Glu Asn Ile Ser Tyr Gly Ile Glu 
        115                 120                 125             


Pro Val Glu Ser Ser Ala Arg Phe Glu His Ile Ile Tyr Gln Met Lys 
    130                 135                 140                 


Asn Asn Asp Pro Asn Val Ser Ile Leu Ala Val Asn Tyr Ser His Ile 
145                 150                 155                 160 


Trp Gln Lys Asp Gln Pro Tyr Lys Val Pro Leu Asn Ser Gln Ile Lys 
                165                 170                 175     


Asn Leu Ser Lys Leu Leu Pro Gln Tyr Leu Glu Ile Tyr Ile Ile Val 
            180                 185                 190         


Glu Lys Ala Leu Met Phe Thr Gln Phe Lys Leu Thr Val Ile Leu Ser 
        195                 200                 205             


Ser Leu Glu Leu Trp Ser Asn Glu Asn Gln Ile Ser Thr Ser Gly Asp 
    210                 215                 220                 


Ala Asp Asp Ile Leu Gln Arg Phe Leu Ala Trp Lys Arg Asp Tyr Leu 
225                 230                 235                 240 


Ile Leu Arg Pro His Asp Ile Ala Tyr Leu Leu Val Tyr Arg Lys His 
                245                 250                 255     


Pro Lys Tyr Val Gly Ala Thr Phe Pro Gly Thr Val Cys Asn Lys Ser 
            260                 265                 270         


Tyr Asp Ala Gly Ile Ala Met Tyr Pro Asp Ala Ile Gly Leu Glu Gly 
        275                 280                 285             


Phe Ser Val Ile Ile Ala Gln Leu Leu Gly Leu Asn Val Gly Leu Thr 
    290                 295                 300                 


Tyr Asp Asp Ile Thr Gln Cys Phe Cys Leu Arg Ala Thr Cys Ile Met 
305                 310                 315                 320 


Asn His Glu Ala Val Ser Ala Ser Gly Arg Lys Ile Phe Ser Asn Cys 
                325                 330                 335     


Ser Met His Asp Tyr Arg Tyr Phe Val Ser Lys Phe Glu Thr Lys Cys 
            340                 345                 350         


Leu Gln Lys Leu Ser Asn Leu Gln Pro Leu His Gln Asn Gln Pro Val 
        355                 360                 365             


Cys Gly Asn Gly Ile Leu Glu Ser Asn Glu Glu Cys Asp Cys Gly Asn 
    370                 375                 380                 


Lys Asn Glu Cys Gln Phe Lys Lys Cys Cys Asp Tyr Asn Thr Cys Lys 
385                 390                 395                 400 


Leu Lys Gly Ser Val Lys Cys Gly Ser Gly Pro Cys Cys Thr Ser Lys 
                405                 410                 415     


Cys Glu Leu Ser Ile Ala Gly Thr Pro Cys Arg Lys Ser Ile Asp Pro 
            420                 425                 430         


Glu Cys Asp Phe Thr Glu Tyr Cys Asn Gly Thr Ser Ser Asn Cys Val 
        435                 440                 445             


Pro Asp Thr Tyr Ala Leu Asn Gly Arg Leu Cys Lys Leu Gly Thr Ala 
    450                 455                 460                 


Tyr Cys Tyr Asn Gly Gln Cys Gln Thr Thr Asp Asn Gln Cys Ala Lys 
465                 470                 475                 480 


Ile Phe Gly Lys Gly Ala Gln Gly Ala Pro Phe Ala Cys Phe Lys Glu 
                485                 490                 495     


Val Asn Ser Leu His Glu Arg Ser Glu Asn Cys Gly Phe Lys Asn Ser 
            500                 505                 510         


Gln Pro Leu Pro Cys Glu Arg Lys Asp Val Leu Cys Gly Lys Leu Ala 
        515                 520                 525             


Cys Val Gln Pro His Lys Asn Ala Asn Lys Ser Asp Ala Gln Ser Thr 
    530                 535                 540                 


Val Tyr Ser Tyr Ile Gln Asp His Val Cys Val Ser Ile Ala Thr Gly 
545                 550                 555                 560 


Ser Ser Met Arg Ser Asp Gly Thr Asp Asn Ala Tyr Val Ala Asp Gly 
                565                 570                 575     


Thr Met Cys Gly Pro Glu Met Tyr Cys Val Asn Lys Thr Cys Arg Lys 
            580                 585                 590         


Val His Leu Met Gly Tyr Asn Cys Asn Ala Thr Thr Lys Cys Lys Gly 
        595                 600                 605             


Lys Gly Ile Cys Asn Asn Phe Gly Asn Cys Gln Cys Phe Pro Gly His 
    610                 615                 620                 


Arg Pro Pro Asp Cys Lys Phe Gln Phe Gly Ser Pro Gly Gly Ser Ile 
625                 630                 635                 640 


Asp Asp Gly Asn Phe Gln Lys Ser Gly Asp Phe Tyr Thr Glu Lys Gly 
                645                 650                 655     


Tyr Asn Thr His Trp Asn Asn Trp Phe Ile Leu Ser Phe Cys Ile Phe 
            660                 665                 670         


Leu Pro Phe Phe Ile Val Phe Thr Thr Val Ile Phe Lys Arg Asn Glu 
        675                 680                 685             


Ile Ser Lys Ser Cys Asn Arg Glu Asn Ala Glu Tyr Asn Arg Asn Ser 
    690                 695                 700                 


Ser Val Val Ser Glu Ser Asp Asp Val Gly His 
705                 710                 715 


<210>  258
<211>  739
<212>  PRT
<213>  Homo Sapiens

<400>  258

Met Phe Leu Leu Leu Ala Leu Leu Thr Glu Leu Gly Arg Leu Gln Ala 
1               5                   10                  15      


His Glu Gly Ser Glu Gly Ile Phe Leu His Val Thr Val Pro Arg Lys 
            20                  25                  30          


Ile Lys Ser Asn Asp Ser Glu Val Ser Glu Arg Lys Met Ile Tyr Ile 
        35                  40                  45              


Ile Thr Ile Asp Gly Gln Pro Tyr Thr Leu His Leu Gly Lys Gln Ser 
    50                  55                  60                  


Phe Leu Pro Gln Asn Phe Leu Val Tyr Thr Tyr Asn Glu Thr Gly Ser 
65                  70                  75                  80  


Leu His Ser Val Ser Pro Tyr Phe Met Met His Cys His Tyr Gln Gly 
                85                  90                  95      


Tyr Ala Ala Glu Phe Pro Asn Ser Phe Val Thr Leu Ser Ile Cys Ser 
            100                 105                 110         


Gly Leu Arg Gly Phe Leu Gln Phe Glu Asn Ile Ser Tyr Gly Ile Glu 
        115                 120                 125             


Pro Val Glu Ser Ser Ala Arg Phe Glu His Ile Ile Tyr Gln Met Lys 
    130                 135                 140                 


Asn Asn Asp Pro Asn Val Ser Ile Leu Ala Val Asn Tyr Ser His Ile 
145                 150                 155                 160 


Trp Gln Lys Asp Gln Pro Tyr Lys Val Pro Leu Asn Ser Gln Ile Lys 
                165                 170                 175     


Asn Leu Ser Lys Leu Leu Pro Gln Tyr Leu Glu Ile Tyr Ile Ile Val 
            180                 185                 190         


Glu Lys Ala Leu Tyr Asp Tyr Met Gly Ser Glu Met Met Ala Val Thr 
        195                 200                 205             


Gln Lys Ile Val Gln Val Ile Gly Leu Val Asn Thr Met Phe Thr Gln 
    210                 215                 220                 


Phe Lys Leu Thr Val Ile Leu Ser Ser Leu Glu Leu Trp Ser Asn Glu 
225                 230                 235                 240 


Asn Gln Ile Ser Thr Ser Gly Asp Ala Asp Asp Ile Leu Gln Arg Phe 
                245                 250                 255     


Leu Ala Trp Lys Arg Asp Tyr Leu Ile Leu Arg Pro His Asp Ile Ala 
            260                 265                 270         


Tyr Leu Leu Val Tyr Arg Lys His Pro Lys Tyr Val Gly Ala Thr Phe 
        275                 280                 285             


Pro Gly Thr Val Cys Asn Lys Ser Tyr Asp Ala Gly Ile Ala Met Tyr 
    290                 295                 300                 


Pro Asp Ala Ile Gly Leu Glu Gly Phe Ser Val Ile Ile Ala Gln Leu 
305                 310                 315                 320 


Leu Gly Leu Asn Val Gly Leu Thr Tyr Asp Asp Ile Thr Gln Cys Phe 
                325                 330                 335     


Cys Leu Arg Ala Thr Cys Ile Met Asn His Glu Ala Val Ser Ala Ser 
            340                 345                 350         


Gly Arg Lys Ile Phe Ser Asn Cys Ser Met His Asp Tyr Arg Tyr Phe 
        355                 360                 365             


Val Ser Lys Phe Glu Thr Lys Cys Leu Gln Lys Leu Ser Asn Leu Gln 
    370                 375                 380                 


Pro Leu His Gln Asn Gln Pro Val Cys Gly Asn Gly Ile Leu Glu Ser 
385                 390                 395                 400 


Asn Glu Glu Cys Asp Cys Gly Asn Lys Asn Glu Cys Gln Phe Lys Lys 
                405                 410                 415     


Cys Cys Asp Tyr Asn Thr Cys Lys Leu Lys Gly Ser Val Lys Cys Gly 
            420                 425                 430         


Ser Gly Pro Cys Cys Thr Ser Lys Cys Glu Leu Ser Ile Ala Gly Thr 
        435                 440                 445             


Pro Cys Arg Lys Ser Ile Asp Pro Glu Cys Asp Phe Thr Glu Tyr Cys 
    450                 455                 460                 


Asn Gly Thr Ser Ser Asn Cys Val Pro Asp Thr Tyr Ala Leu Asn Gly 
465                 470                 475                 480 


Arg Leu Cys Lys Leu Gly Thr Ala Tyr Cys Tyr Asn Gly Gln Cys Gln 
                485                 490                 495     


Thr Thr Asp Asn Gln Cys Ala Lys Ile Phe Gly Lys Gly Ala Gln Gly 
            500                 505                 510         


Ala Pro Phe Ala Cys Phe Lys Glu Val Asn Ser Leu His Glu Arg Ser 
        515                 520                 525             


Glu Asn Cys Gly Phe Lys Asn Ser Gln Pro Leu Pro Cys Glu Arg Lys 
    530                 535                 540                 


Asp Val Leu Cys Gly Lys Leu Ala Cys Val Gln Pro His Lys Asn Ala 
545                 550                 555                 560 


Asn Lys Ser Asp Ala Gln Ser Thr Val Tyr Ser Tyr Ile Gln Asp His 
                565                 570                 575     


Val Cys Val Ser Ile Ala Thr Gly Ser Ser Met Arg Ser Asp Gly Thr 
            580                 585                 590         


Asp Asn Ala Tyr Val Ala Asp Gly Thr Met Cys Gly Pro Glu Met Tyr 
        595                 600                 605             


Cys Val Asn Lys Thr Cys Arg Lys Val His Leu Met Gly Tyr Asn Cys 
    610                 615                 620                 


Asn Ala Thr Thr Lys Cys Lys Gly Lys Gly Ile Cys Asn Asn Phe Gly 
625                 630                 635                 640 


Asn Cys Gln Cys Phe Pro Gly His Arg Pro Pro Asp Cys Lys Phe Gln 
                645                 650                 655     


Phe Gly Ser Pro Gly Gly Ser Ile Asp Asp Gly Asn Phe Gln Lys Ser 
            660                 665                 670         


Gly Asp Phe Tyr Thr Glu Lys Gly Tyr Asn Thr His Trp Asn Asn Trp 
        675                 680                 685             


Phe Ile Leu Ser Phe Cys Ile Phe Leu Pro Phe Phe Ile Val Phe Thr 
    690                 695                 700                 


Thr Val Ile Phe Lys Arg Asn Glu Ile Ser Lys Ser Cys Asn Arg Glu 
705                 710                 715                 720 


Asn Ala Glu Tyr Asn Arg Asn Ser Ser Val Val Ser Glu Ser Asp Asp 
                725                 730                 735     


Val Gly His 
            


<210>  259
<211>  182
<212>  PRT
<213>  Homo Sapiens

<400>  259

Met Phe Leu Leu Leu Ala Leu Leu Thr Glu Leu Gly Arg Leu Gln Ala 
1               5                   10                  15      


His Glu Gly Ser Glu Gly Ile Phe Leu His Val Thr Val Pro Arg Lys 
            20                  25                  30          


Ile Lys Ser Asn Asp Ser Glu Val Ser Glu Arg Lys Met Ile Tyr Ile 
        35                  40                  45              


Ile Thr Ile Asp Gly Gln Pro Tyr Thr Leu His Leu Gly Lys Gln Ser 
    50                  55                  60                  


Phe Leu Pro Gln Asn Phe Leu Val Tyr Thr Tyr Asn Glu Thr Gly Ser 
65                  70                  75                  80  


Leu His Ser Val Ser Pro Tyr Phe Met Met His Cys His Tyr Gln Gly 
                85                  90                  95      


Tyr Ala Ala Glu Phe Pro Asn Ser Phe Val Thr Leu Ser Ile Cys Ser 
            100                 105                 110         


Gly Leu Arg Gly Phe Leu Gln Phe Glu Asn Ile Ser Tyr Gly Ile Glu 
        115                 120                 125             


Pro Val Glu Ser Ser Ala Arg Phe Glu His Ile Ile Tyr Gln Met Lys 
    130                 135                 140                 


Asn Asn Asp Pro Asn Val Ser Ile Leu Ala Val Asn Tyr Ser His Ile 
145                 150                 155                 160 


Trp Gln Lys Asp Gln Pro Tyr Lys Val Pro Leu Asn Ser Gln Val Thr 
                165                 170                 175     


Val Ile Ile Leu Met Leu 
            180         


<210>  260
<211>  62
<212>  PRT
<213>  Homo Sapiens

<400>  260

Met Phe Leu Leu Leu Ala Leu Leu Thr Glu Leu Gly Arg Leu Gln Ala 
1               5                   10                  15      


His Glu Gly Ser Glu Gly Ile Phe Leu His Val Thr Val Pro Arg Lys 
            20                  25                  30          


Ile Lys Ser Asn Asp Ser Glu Val Ser Glu Arg Lys Val Phe Gly Glu 
        35                  40                  45              


Gln Val Val Phe Gly Tyr Met Asn Asp Leu His His Tyr Asn 
    50                  55                  60          


<210>  261
<211>  330
<212>  PRT
<213>  Homo Sapiens

<400>  261

Glu Glu Asp Val Asp Leu Gly Tyr Val Glu Asp Gly Thr Pro Cys Gly 
1               5                   10                  15      


Pro Gln Met Met Cys Leu Glu His Arg Cys Leu Pro Val Ala Ser Phe 
            20                  25                  30          


Asn Phe Ser Thr Cys Leu Ser Ser Lys Glu Gly Thr Ile Cys Ser Gly 
        35                  40                  45              


Asn Gly Val Cys Ser Asn Glu Leu Lys Cys Val Cys Asn Arg His Trp 
    50                  55                  60                  


Ile Gly Ser Asp Cys Asn Thr Tyr Phe Pro His Asn Asp Asp Ala Lys 
65                  70                  75                  80  


Thr Gly Ile Thr Leu Ser Gly Asn Gly Val Ala Gly Thr Asn Ile Ile 
                85                  90                  95      


Ile Gly Ile Ile Ala Gly Thr Ile Leu Val Leu Ala Leu Ile Leu Gly 
            100                 105                 110         


Ile Thr Ala Trp Gly Tyr Lys Asn Tyr Arg Glu Gln Arg Gln Leu Pro 
        115                 120                 125             


Gln Gly Asp Tyr Val Lys Lys Pro Gly Asp Gly Asp Ser Phe Tyr Ser 
    130                 135                 140                 


Asp Ile Pro Pro Gly Val Ser Thr Asn Ser Ala Ser Ser Ser Lys Lys 
145                 150                 155                 160 


Arg Ser Asn Gly Leu Ser His Ser Trp Ser Glu Arg Ile Pro Asp Thr 
                165                 170                 175     


Lys His Ile Ser Asp Ile Cys Glu Asn Gly Arg Pro Arg Ser Asn Ser 
            180                 185                 190         


Trp Gln Gly Asn Leu Gly Gly Asn Lys Lys Lys Ile Arg Gly Lys Arg 
        195                 200                 205             


Phe Arg Pro Arg Ser Asn Ser Thr Glu Arg Glu Pro Gln Ala Pro Glu 
    210                 215                 220                 


Pro Gly His Ser Leu Ala Gln Thr Val Pro Ser Gln Gly Ile Ser Pro 
225                 230                 235                 240 


Gly Gly Ser Asp Ser Pro Gln Thr Gly Ser Leu Asp His Arg Tyr Leu 
                245                 250                 255     


Asn Pro Trp Phe Lys Arg Asp Tyr Asn Val Ala Lys Trp Val Glu Asp 
            260                 265                 270         


Val Asn Lys Asn Thr Glu Gly Pro Tyr Phe Arg Thr Leu Ser Pro Ala 
        275                 280                 285             


Lys Ser Pro Ser Ser Ser Thr Gly Ser Ile Ala Ser Ser Arg Lys Tyr 
    290                 295                 300                 


Pro Tyr Pro Met Pro Pro Leu Pro Asp Glu Asp Lys Lys Val Asn Arg 
305                 310                 315                 320 


Gln Ser Ala Arg Leu Trp Glu Thr Ser Ile 
                325                 330 


<210>  262
<211>  804
<212>  PRT
<213>  Homo Sapiens

<400>  262

Met Glu Leu Glu Lys Arg Lys Glu Asn Arg Phe Val Glu Arg Gln Ser 
1               5                   10                  15      


Ile Val Pro Leu Arg Leu Ile Tyr Arg Ser Gly Gly Glu Asp Glu Ser 
            20                  25                  30          


Arg His Asp Ala Leu Asp Thr Arg Val Arg Gly Asp Leu Gly Gly Pro 
        35                  40                  45              


Gln Leu Thr His Val Asp Gln Ala Ser Phe Gln Val Asp Ala Phe Gly 
    50                  55                  60                  


Thr Ser Phe Ile Leu Asp Val Val Leu Asn His Asp Leu Leu Ser Ser 
65                  70                  75                  80  


Glu Tyr Ile Glu Arg His Ile Glu His Gly Gly Lys Thr Val Glu Val 
                85                  90                  95      


Lys Gly Gly Glu His Cys Tyr Tyr Gln Gly His Ile Arg Gly Asn Pro 
            100                 105                 110         


Asp Ser Phe Val Ala Leu Ser Thr Cys His Gly Leu His Gly Met Phe 
        115                 120                 125             


Tyr Asp Gly Asn His Thr Tyr Leu Ile Glu Pro Glu Glu Asn Asp Thr 
    130                 135                 140                 


Thr Gln Glu Asp Phe His Phe His Ser Val Tyr Lys Ser Arg Leu Phe 
145                 150                 155                 160 


Glu Phe Ser Leu Asp Asp Leu Pro Ser Glu Phe Gln Gln Val Asn Ile 
                165                 170                 175     


Thr Pro Ser Lys Phe Ile Leu Lys Pro Arg Pro Lys Arg Ser Lys Arg 
            180                 185                 190         


Gln Leu Arg Arg Tyr Pro Arg Asn Val Glu Glu Glu Thr Lys Tyr Ile 
        195                 200                 205             


Glu Leu Met Ile Val Asn Asp His Leu Met Phe Lys Lys His Arg Leu 
    210                 215                 220                 


Ser Val Val His Thr Asn Thr Tyr Ala Lys Ser Val Val Asn Met Ala 
225                 230                 235                 240 


Asp Leu Ile Tyr Lys Asp Gln Leu Lys Thr Arg Ile Val Leu Val Ala 
                245                 250                 255     


Met Glu Thr Trp Ala Thr Asp Asn Lys Phe Ala Ile Ser Glu Asn Pro 
            260                 265                 270         


Leu Ile Thr Leu Arg Glu Phe Met Lys Tyr Arg Arg Asp Phe Ile Lys 
        275                 280                 285             


Glu Lys Ser Asp Ala Val His Leu Phe Ser Gly Ser Gln Phe Glu Ser 
    290                 295                 300                 


Ser Arg Ser Gly Ala Ala Tyr Ile Gly Gly Ile Cys Ser Leu Leu Lys 
305                 310                 315                 320 


Gly Gly Gly Val Asn Glu Phe Gly Lys Thr Asp Leu Met Ala Val Thr 
                325                 330                 335     


Leu Ala Gln Ser Leu Ala His Asn Ile Gly Ile Ile Ser Asp Lys Arg 
            340                 345                 350         


Lys Leu Ala Ser Gly Glu Cys Lys Cys Glu Asp Thr Trp Ser Gly Cys 
        355                 360                 365             


Ile Met Gly Asp Thr Gly Tyr Tyr Leu Pro Lys Lys Phe Thr Gln Cys 
    370                 375                 380                 


Asn Ile Glu Glu Tyr His Asp Phe Leu Asn Ser Gly Gly Gly Ala Cys 
385                 390                 395                 400 


Leu Phe Asn Lys Pro Ser Lys Leu Leu Asp Pro Pro Glu Cys Gly Asn 
                405                 410                 415     


Gly Phe Ile Glu Thr Gly Glu Glu Cys Asp Cys Gly Thr Pro Ala Glu 
            420                 425                 430         


Cys Val Leu Glu Gly Ala Glu Cys Cys Lys Lys Cys Thr Leu Thr Gln 
        435                 440                 445             


Asp Ser Gln Cys Ser Asp Gly Leu Cys Cys Lys Lys Cys Lys Phe Gln 
    450                 455                 460                 


Pro Met Gly Thr Val Cys Arg Glu Ala Val Asn Asp Cys Asp Ile Arg 
465                 470                 475                 480 


Glu Thr Cys Ser Gly Asn Ser Ser Gln Cys Ala Pro Asn Ile His Lys 
                485                 490                 495     


Met Asp Gly Tyr Ser Cys Asp Gly Val Gln Gly Ile Cys Phe Gly Gly 
            500                 505                 510         


Arg Cys Lys Thr Arg Asp Arg Gln Cys Lys Tyr Ile Trp Gly Gln Lys 
        515                 520                 525             


Val Thr Ala Ser Asp Lys Tyr Cys Tyr Glu Lys Leu Asn Ile Glu Gly 
    530                 535                 540                 


Thr Glu Lys Gly Asn Cys Gly Lys Asp Lys Asp Thr Trp Ile Gln Cys 
545                 550                 555                 560 


Asn Lys Arg Asp Val Leu Cys Gly Tyr Leu Leu Cys Thr Asn Ile Gly 
                565                 570                 575     


Asn Ile Pro Arg Leu Gly Glu Leu Asp Gly Glu Ile Thr Ser Thr Leu 
            580                 585                 590         


Val Val Gln Gln Gly Arg Thr Leu Asn Cys Ser Gly Gly His Val Lys 
        595                 600                 605             


Leu Glu Glu Asp Val Asp Leu Gly Tyr Val Glu Asp Gly Thr Pro Cys 
    610                 615                 620                 


Gly Pro Gln Met Met Cys Leu Glu His Arg Cys Leu Pro Val Ala Ser 
625                 630                 635                 640 


Phe Asn Phe Ser Thr Cys Leu Ser Ser Lys Glu Gly Thr Ile Cys Ser 
                645                 650                 655     


Gly Asn Gly Val Cys Ser Asn Glu Leu Lys Cys Val Cys Asn Arg His 
            660                 665                 670         


Trp Ile Gly Ser Asp Cys Asn Thr Tyr Phe Pro His Asn Asp Asp Ala 
        675                 680                 685             


Lys Thr Gly Ile Thr Leu Ser Gly Asn Gly Val Ala Gly Thr Asn Ile 
    690                 695                 700                 


Ile Ile Gly Ile Ile Ala Gly Thr Ile Leu Val Leu Ala Leu Ile Leu 
705                 710                 715                 720 


Gly Ile Thr Ala Trp Gly Tyr Lys Asn Tyr Arg Glu Gln Arg Gln Leu 
                725                 730                 735     


Pro Gln Gly Asp Tyr Val Lys Lys Pro Gly Asp Gly Asp Ser Phe Tyr 
            740                 745                 750         


Ser Asp Ile Pro Pro Gly Val Ser Thr Asn Ser Ala Ser Ser Ser Lys 
        755                 760                 765             


Lys Arg Ser Asn Gly Leu Ser His Ser Trp Ser Glu Arg Ile Pro Asp 
    770                 775                 780                 


Thr Lys His Ile Ser Asp Ile Cys Glu Asn Gly Arg Pro Arg Ser Asn 
785                 790                 795                 800 


Ser Trp Gln Gly 
                


<210>  263
<211>  196
<212>  PRT
<213>  Homo Sapiens

<400>  263

Met Gln Ala Ala Val Ala Val Ser Val Pro Phe Leu Leu Leu Cys Val 
1               5                   10                  15      


Leu Gly Thr Cys Pro Pro Ala Arg Cys Gly Gln Ala Gly Asp Ala Ser 
            20                  25                  30          


Leu Met Glu Leu Glu Lys Arg Lys Glu Asn Arg Phe Val Glu Arg Gln 
        35                  40                  45              


Ser Ile Val Pro Leu Arg Leu Ile Tyr Arg Ser Gly Gly Glu Asp Glu 
    50                  55                  60                  


Ser Arg His Asp Ala Leu Asp Thr Arg Val Arg Gly Asp Leu Gly Gly 
65                  70                  75                  80  


Pro Gln Ile Gln Met Phe Leu Lys Ser Glu Ser Gln Lys Thr Ile Tyr 
                85                  90                  95      


Gln Ile Gln Leu Thr His Val Asp Gln Ala Ser Phe Gln Val Asp Ala 
            100                 105                 110         


Phe Gly Thr Ser Phe Ile Leu Asp Val Val Leu Asn His Asp Leu Leu 
        115                 120                 125             


Ser Ser Glu Tyr Ile Glu Arg His Ile Glu His Gly Gly Lys Thr Val 
    130                 135                 140                 


Glu Val Lys Gly Gly Glu His Cys Tyr Tyr Gln Gly His Ile Arg Gly 
145                 150                 155                 160 


Asn Pro Asp Ser Phe Val Ala Leu Ser Thr Cys His Gly Leu His Gly 
                165                 170                 175     


Met Phe Tyr Asp Gly Asn His Thr Tyr Leu Ile Glu Pro Glu Glu Asn 
            180                 185                 190         


Asp Thr Thr Gln 
        195     


<210>  264
<211>  906
<212>  PRT
<213>  Homo Sapiens

<400>  264

Met Gln Ala Ala Val Ala Val Ser Val Pro Phe Leu Leu Leu Cys Val 
1               5                   10                  15      


Leu Gly Thr Cys Pro Pro Ala Arg Cys Gly Gln Ala Gly Asp Ala Ser 
            20                  25                  30          


Leu Met Glu Leu Glu Lys Arg Lys Glu Asn Arg Phe Val Glu Arg Gln 
        35                  40                  45              


Ser Ile Val Pro Leu Arg Leu Ile Tyr Arg Ser Gly Gly Glu Asp Glu 
    50                  55                  60                  


Ser Arg His Asp Ala Leu Asp Thr Arg Val Arg Gly Asp Leu Gly Gly 
65                  70                  75                  80  


Pro Gln Leu Thr His Val Asp Gln Ala Ser Phe Gln Val Asp Ala Phe 
                85                  90                  95      


Gly Thr Ser Phe Ile Leu Asp Val Val Leu Asn His Asp Leu Leu Ser 
            100                 105                 110         


Ser Glu Tyr Ile Glu Arg His Ile Glu His Gly Gly Lys Thr Val Glu 
        115                 120                 125             


Val Lys Gly Gly Glu His Cys Tyr Tyr Gln Gly His Ile Arg Gly Asn 
    130                 135                 140                 


Pro Asp Ser Phe Val Ala Leu Ser Thr Cys His Gly Leu His Gly Met 
145                 150                 155                 160 


Phe Tyr Asp Gly Asn His Thr Tyr Leu Ile Glu Pro Glu Glu Asn Asp 
                165                 170                 175     


Thr Thr Gln Glu Asp Phe His Phe His Ser Val Tyr Lys Ser Arg Leu 
            180                 185                 190         


Phe Glu Phe Ser Leu Asp Asp Leu Pro Ser Glu Phe Gln Gln Val Asn 
        195                 200                 205             


Ile Thr Pro Ser Lys Phe Ile Leu Lys Pro Arg Pro Lys Arg Ser Lys 
    210                 215                 220                 


Arg Gln Leu Arg Arg Tyr Pro Arg Asn Val Glu Glu Glu Thr Lys Tyr 
225                 230                 235                 240 


Ile Glu Leu Met Ile Val Asn Asp His Leu Met Phe Lys Lys His Arg 
                245                 250                 255     


Leu Ser Val Val His Thr Asn Thr Tyr Ala Lys Ser Val Val Asn Met 
            260                 265                 270         


Ala Asp Leu Ile Tyr Lys Asp Gln Leu Lys Thr Arg Ile Val Leu Val 
        275                 280                 285             


Ala Met Glu Thr Trp Ala Thr Asp Asn Lys Phe Ala Ile Ser Glu Asn 
    290                 295                 300                 


Pro Leu Ile Thr Leu Arg Glu Phe Met Lys Tyr Arg Arg Asp Phe Ile 
305                 310                 315                 320 


Lys Glu Lys Ser Asp Ala Val His Leu Phe Ser Gly Ser Gln Phe Glu 
                325                 330                 335     


Ser Ser Arg Ser Gly Ala Ala Tyr Ile Gly Gly Ile Cys Ser Leu Leu 
            340                 345                 350         


Lys Gly Gly Gly Val Asn Glu Phe Gly Lys Thr Asp Leu Met Ala Val 
        355                 360                 365             


Thr Leu Ala Gln Ser Leu Ala His Asn Ile Gly Ile Ile Ser Asp Lys 
    370                 375                 380                 


Arg Lys Leu Ala Ser Gly Glu Cys Lys Cys Glu Asp Thr Trp Ser Gly 
385                 390                 395                 400 


Cys Ile Met Gly Asp Thr Gly Tyr Tyr Leu Pro Lys Lys Phe Thr Gln 
                405                 410                 415     


Cys Asn Ile Glu Glu Tyr His Asp Phe Leu Asn Ser Gly Gly Gly Ala 
            420                 425                 430         


Cys Leu Phe Asn Lys Pro Ser Lys Leu Leu Asp Pro Pro Glu Cys Gly 
        435                 440                 445             


Asn Gly Phe Ile Glu Thr Gly Glu Glu Cys Asp Cys Gly Thr Pro Ala 
    450                 455                 460                 


Glu Cys Val Leu Glu Gly Ala Glu Cys Cys Lys Lys Cys Thr Leu Thr 
465                 470                 475                 480 


Gln Asp Ser Gln Cys Ser Asp Gly Leu Cys Cys Lys Lys Cys Lys Phe 
                485                 490                 495     


Gln Pro Met Gly Thr Val Cys Arg Glu Ala Val Asn Asp Cys Asp Ile 
            500                 505                 510         


Arg Glu Thr Cys Ser Gly Asn Ser Ser Gln Cys Ala Pro Asn Ile His 
        515                 520                 525             


Lys Met Asp Gly Tyr Ser Cys Asp Gly Val Gln Gly Ile Cys Phe Gly 
    530                 535                 540                 


Gly Arg Cys Lys Thr Arg Asp Arg Gln Cys Lys Tyr Ile Trp Gly Gln 
545                 550                 555                 560 


Lys Val Thr Ala Ser Asp Lys Tyr Cys Tyr Glu Lys Leu Asn Ile Glu 
                565                 570                 575     


Gly Thr Glu Lys Gly Asn Cys Gly Lys Asp Lys Asp Thr Trp Ile Gln 
            580                 585                 590         


Cys Asn Lys Arg Asp Val Leu Cys Gly Tyr Leu Leu Cys Thr Asn Ile 
        595                 600                 605             


Gly Asn Ile Pro Arg Leu Gly Glu Leu Asp Gly Glu Ile Thr Ser Thr 
    610                 615                 620                 


Leu Val Val Gln Gln Gly Arg Thr Leu Asn Cys Ser Gly Gly His Val 
625                 630                 635                 640 


Lys Leu Glu Glu Asp Val Asp Leu Gly Tyr Val Glu Asp Gly Thr Pro 
                645                 650                 655     


Cys Gly Pro Gln Met Met Cys Leu Glu His Arg Cys Leu Pro Val Ala 
            660                 665                 670         


Ser Phe Asn Phe Ser Thr Cys Leu Ser Ser Lys Glu Gly Thr Ile Cys 
        675                 680                 685             


Ser Gly Asn Gly Val Cys Ser Asn Glu Leu Lys Cys Val Cys Asn Arg 
    690                 695                 700                 


His Trp Ile Gly Ser Asp Cys Asn Thr Tyr Phe Pro His Asn Asp Asp 
705                 710                 715                 720 


Ala Lys Thr Gly Ile Thr Leu Ser Gly Asn Gly Val Ala Gly Thr Asn 
                725                 730                 735     


Ile Ile Ile Gly Ile Ile Ala Gly Thr Ile Leu Val Leu Ala Leu Ile 
            740                 745                 750         


Leu Gly Ile Thr Ala Trp Gly Tyr Lys Asn Tyr Arg Glu Gln Arg Gln 
        755                 760                 765             


Leu Pro Gln Gly Asp Tyr Val Lys Lys Pro Gly Asp Gly Asp Ser Phe 
    770                 775                 780                 


Tyr Ser Asp Ile Pro Pro Gly Val Ser Thr Asn Ser Ala Ser Ser Ser 
785                 790                 795                 800 


Lys Lys Arg Ser Asn Gly Leu Ser His Ser Trp Ser Glu Arg Ile Pro 
                805                 810                 815     


Asp Thr Lys His Ile Ser Asp Ile Cys Glu Asn Gly Arg Pro Arg Ser 
            820                 825                 830         


Asn Ser Trp Gln Gly Asn Leu Gly Gly Asn Lys Lys Lys Ile Arg Gly 
        835                 840                 845             


Lys Arg Phe Arg Pro Arg Ser Asn Ser Thr Glu Thr Leu Ser Pro Ala 
    850                 855                 860                 


Lys Ser Pro Ser Ser Ser Thr Gly Ser Ile Ala Ser Ser Arg Lys Tyr 
865                 870                 875                 880 


Pro Tyr Pro Met Pro Pro Leu Pro Asp Glu Asp Lys Lys Val Asn Arg 
                885                 890                 895     


Gln Ser Ala Arg Leu Trp Glu Thr Ser Ile 
            900                 905     


<210>  265
<211>  859
<212>  PRT
<213>  Homo Sapiens

<400>  265

Met Gln Ala Ala Val Ala Val Ser Val Pro Phe Leu Leu Leu Cys Val 
1               5                   10                  15      


Leu Gly Thr Cys Pro Pro Ala Arg Cys Gly Gln Ala Gly Asp Ala Ser 
            20                  25                  30          


Leu Met Glu Leu Glu Lys Arg Lys Glu Asn Arg Phe Val Glu Arg Gln 
        35                  40                  45              


Ser Ile Val Pro Leu Arg Leu Ile Tyr Arg Ser Gly Gly Glu Asp Glu 
    50                  55                  60                  


Ser Arg His Asp Ala Leu Asp Thr Arg Val Arg Gly Asp Leu Gly Gly 
65                  70                  75                  80  


Pro Gln Leu Thr His Val Asp Gln Ala Ser Phe Gln Val Asp Ala Phe 
                85                  90                  95      


Gly Thr Ser Phe Ile Leu Asp Val Val Leu Asn His Asp Leu Leu Ser 
            100                 105                 110         


Ser Glu Tyr Ile Glu Arg His Ile Glu His Gly Gly Lys Thr Val Glu 
        115                 120                 125             


Val Lys Gly Gly Glu His Cys Tyr Tyr Gln Gly His Ile Arg Gly Asn 
    130                 135                 140                 


Pro Asp Ser Phe Val Ala Leu Ser Thr Cys His Gly Leu His Gly Met 
145                 150                 155                 160 


Phe Tyr Asp Gly Asn His Thr Tyr Leu Ile Glu Pro Glu Glu Asn Asp 
                165                 170                 175     


Thr Thr Gln Glu Asp Phe His Phe His Ser Val Tyr Lys Ser Arg Leu 
            180                 185                 190         


Phe Glu Phe Ser Leu Asp Asp Leu Pro Ser Glu Phe Gln Gln Val Asn 
        195                 200                 205             


Ile Thr Pro Ser Lys Phe Ile Leu Lys Pro Arg Pro Lys Arg Ser Lys 
    210                 215                 220                 


Arg Gln Leu Arg Arg Tyr Pro Arg Asn Val Glu Glu Glu Thr Lys Tyr 
225                 230                 235                 240 


Ile Glu Leu Met Ile Val Asn Asp His Leu Met Phe Lys Lys His Arg 
                245                 250                 255     


Leu Ser Val Val His Thr Asn Thr Tyr Ala Lys Ser Val Val Asn Met 
            260                 265                 270         


Ala Asp Leu Ile Tyr Lys Asp Gln Leu Lys Thr Arg Ile Val Leu Val 
        275                 280                 285             


Ala Met Glu Thr Trp Ala Thr Asp Asn Lys Phe Ala Ile Ser Glu Asn 
    290                 295                 300                 


Pro Leu Ile Thr Leu Arg Glu Phe Met Lys Tyr Arg Arg Asp Phe Ile 
305                 310                 315                 320 


Lys Glu Lys Ser Asp Ala Val His Leu Phe Ser Gly Ser Gln Phe Glu 
                325                 330                 335     


Ser Ser Arg Ser Gly Ala Ala Tyr Ile Gly Gly Ile Cys Ser Leu Leu 
            340                 345                 350         


Lys Gly Gly Gly Val Asn Glu Phe Gly Lys Thr Asp Leu Met Ala Val 
        355                 360                 365             


Thr Leu Ala Gln Ser Leu Ala His Asn Ile Gly Ile Ile Ser Asp Lys 
    370                 375                 380                 


Arg Lys Leu Ala Ser Gly Glu Cys Lys Cys Glu Asp Thr Trp Ser Gly 
385                 390                 395                 400 


Cys Ile Met Gly Asp Thr Gly Tyr Tyr Leu Pro Lys Lys Phe Thr Gln 
                405                 410                 415     


Cys Asn Ile Glu Glu Tyr His Asp Phe Leu Asn Ser Gly Gly Gly Ala 
            420                 425                 430         


Cys Leu Phe Asn Lys Pro Ser Lys Leu Leu Asp Pro Pro Glu Cys Gly 
        435                 440                 445             


Asn Gly Phe Ile Glu Thr Gly Glu Glu Cys Asp Cys Gly Thr Pro Ala 
    450                 455                 460                 


Glu Cys Val Leu Glu Gly Ala Glu Cys Cys Lys Lys Cys Thr Leu Thr 
465                 470                 475                 480 


Gln Asp Ser Gln Cys Ser Asp Gly Leu Cys Cys Lys Lys Cys Lys Phe 
                485                 490                 495     


Gln Pro Met Gly Thr Val Cys Arg Glu Ala Val Asn Asp Cys Asp Ile 
            500                 505                 510         


Arg Glu Thr Cys Ser Gly Asn Ser Ser Gln Cys Ala Pro Asn Ile His 
        515                 520                 525             


Lys Met Asp Gly Tyr Ser Cys Asp Gly Val Gln Gly Ile Cys Phe Gly 
    530                 535                 540                 


Gly Arg Cys Lys Thr Arg Asp Arg Gln Cys Lys Tyr Ile Trp Gly Gln 
545                 550                 555                 560 


Lys Val Thr Ala Ser Asp Lys Tyr Cys Tyr Glu Lys Leu Asn Ile Glu 
                565                 570                 575     


Gly Thr Glu Lys Gly Asn Cys Gly Lys Asp Lys Asp Thr Trp Ile Gln 
            580                 585                 590         


Cys Asn Lys Arg Asp Val Leu Cys Gly Tyr Leu Leu Cys Thr Asn Ile 
        595                 600                 605             


Gly Asn Ile Pro Arg Leu Gly Glu Leu Asp Gly Glu Ile Thr Ser Thr 
    610                 615                 620                 


Leu Val Val Gln Gln Gly Arg Thr Leu Asn Cys Ser Gly Gly His Val 
625                 630                 635                 640 


Lys Leu Glu Glu Asp Val Asp Leu Gly Tyr Val Glu Asp Gly Thr Pro 
                645                 650                 655     


Cys Gly Pro Gln Met Met Cys Leu Glu His Arg Cys Leu Pro Val Ala 
            660                 665                 670         


Ser Phe Asn Phe Ser Thr Cys Leu Ser Ser Lys Glu Gly Thr Ile Cys 
        675                 680                 685             


Ser Gly Asn Gly Val Cys Ser Asn Glu Leu Lys Cys Val Cys Asn Arg 
    690                 695                 700                 


His Trp Ile Gly Ser Asp Cys Asn Thr Tyr Phe Pro His Asn Asp Asp 
705                 710                 715                 720 


Ala Lys Thr Gly Ile Thr Leu Ser Gly Asn Gly Val Ala Gly Thr Asn 
                725                 730                 735     


Ile Ile Ile Gly Ile Ile Ala Gly Thr Ile Leu Val Leu Ala Leu Ile 
            740                 745                 750         


Leu Gly Ile Thr Ala Trp Gly Tyr Lys Asn Tyr Arg Glu Gln Arg Gln 
        755                 760                 765             


Leu Pro Gln Gly Asp Tyr Val Lys Lys Pro Gly Asp Gly Asp Ser Phe 
    770                 775                 780                 


Tyr Ser Asp Ile Pro Pro Gly Val Ser Thr Asn Ser Ala Ser Ser Ser 
785                 790                 795                 800 


Lys Lys Arg Ser Asn Gly Leu Ser His Ser Trp Ser Glu Arg Ile Pro 
                805                 810                 815     


Asp Thr Lys His Ile Ser Asp Ile Cys Glu Asn Gly Arg Pro Arg Ser 
            820                 825                 830         


Asn Ser Trp Gln Gly Asn Leu Gly Gly Asn Lys Lys Lys Ile Arg Gly 
        835                 840                 845             


Lys Arg Phe Arg Pro Arg Ser Asn Ser Thr Glu 
    850                 855                 


<210>  266
<211>  899
<212>  PRT
<213>  Homo Sapiens

<400>  266

Met Gln Ala Ala Val Ala Val Ser Val Pro Phe Leu Leu Leu Cys Val 
1               5                   10                  15      


Leu Gly Thr Cys Pro Pro Ala Arg Cys Gly Gln Ala Gly Asp Ala Ser 
            20                  25                  30          


Leu Met Glu Leu Glu Lys Arg Lys Glu Asn Arg Phe Val Glu Arg Gln 
        35                  40                  45              


Ser Ile Val Pro Leu Arg Leu Ile Tyr Arg Ser Gly Gly Glu Asp Glu 
    50                  55                  60                  


Ser Arg His Asp Ala Leu Asp Thr Arg Val Arg Gly Asp Leu Gly Gly 
65                  70                  75                  80  


Pro Gln Leu Thr His Val Asp Gln Ala Ser Phe Gln Val Asp Ala Phe 
                85                  90                  95      


Gly Thr Ser Phe Ile Leu Asp Val Val Leu Asn His Asp Leu Leu Ser 
            100                 105                 110         


Ser Glu Tyr Ile Glu Arg His Ile Glu His Gly Gly Lys Thr Val Glu 
        115                 120                 125             


Val Lys Gly Gly Glu His Cys Tyr Tyr Gln Gly His Ile Arg Gly Asn 
    130                 135                 140                 


Pro Asp Ser Phe Val Ala Leu Ser Thr Cys His Gly Leu His Gly Met 
145                 150                 155                 160 


Phe Tyr Asp Gly Asn His Thr Tyr Leu Ile Glu Pro Glu Glu Asn Asp 
                165                 170                 175     


Thr Thr Gln Glu Asp Phe His Phe His Ser Val Tyr Lys Ser Arg Leu 
            180                 185                 190         


Phe Glu Phe Ser Leu Asp Asp Leu Pro Ser Glu Phe Gln Gln Val Asn 
        195                 200                 205             


Ile Thr Pro Ser Lys Phe Ile Leu Lys Pro Arg Pro Lys Arg Ser Lys 
    210                 215                 220                 


Arg Gln Leu Arg Arg Tyr Pro Arg Asn Val Glu Glu Glu Thr Lys Tyr 
225                 230                 235                 240 


Ile Glu Leu Met Ile Val Asn Asp His Leu Met Phe Lys Lys His Arg 
                245                 250                 255     


Leu Ser Val Val His Thr Asn Thr Tyr Ala Lys Ser Val Val Asn Met 
            260                 265                 270         


Ala Asp Leu Ile Tyr Lys Asp Gln Leu Lys Thr Arg Ile Val Leu Val 
        275                 280                 285             


Ala Met Glu Thr Trp Ala Thr Asp Asn Lys Phe Ala Ile Ser Glu Asn 
    290                 295                 300                 


Pro Leu Ile Thr Leu Arg Glu Phe Met Lys Tyr Arg Arg Asp Phe Ile 
305                 310                 315                 320 


Lys Glu Lys Ser Asp Ala Val His Leu Phe Ser Gly Ser Gln Phe Glu 
                325                 330                 335     


Ser Ser Arg Ser Gly Ala Ala Tyr Ile Gly Gly Ile Cys Ser Leu Leu 
            340                 345                 350         


Lys Gly Gly Gly Val Asn Glu Phe Gly Lys Thr Asp Leu Met Ala Val 
        355                 360                 365             


Thr Leu Ala Gln Ser Leu Ala His Asn Ile Gly Ile Ile Ser Asp Lys 
    370                 375                 380                 


Arg Lys Leu Ala Ser Gly Glu Cys Lys Cys Glu Asp Thr Trp Ser Gly 
385                 390                 395                 400 


Cys Ile Met Gly Asp Thr Gly Tyr Tyr Leu Pro Lys Lys Phe Thr Gln 
                405                 410                 415     


Cys Asn Ile Glu Glu Tyr His Asp Phe Leu Asn Ser Gly Gly Gly Ala 
            420                 425                 430         


Cys Leu Phe Asn Lys Pro Ser Lys Leu Leu Asp Pro Pro Glu Cys Gly 
        435                 440                 445             


Asn Gly Phe Ile Glu Thr Gly Glu Glu Cys Asp Cys Gly Thr Pro Ala 
    450                 455                 460                 


Glu Cys Val Leu Glu Gly Ala Glu Cys Cys Lys Lys Cys Thr Leu Thr 
465                 470                 475                 480 


Gln Asp Ser Gln Cys Ser Asp Gly Leu Cys Cys Lys Lys Cys Lys Phe 
                485                 490                 495     


Gln Pro Met Gly Thr Val Cys Arg Glu Ala Val Asn Asp Cys Asp Ile 
            500                 505                 510         


Arg Glu Thr Cys Ser Gly Asn Ser Ser Gln Cys Ala Pro Asn Ile His 
        515                 520                 525             


Lys Met Asp Gly Tyr Ser Cys Asp Gly Val Gln Gly Ile Cys Phe Gly 
    530                 535                 540                 


Gly Arg Cys Lys Thr Arg Asp Arg Gln Cys Lys Tyr Ile Trp Gly Gln 
545                 550                 555                 560 


Lys Val Thr Ala Ser Asp Lys Tyr Cys Tyr Glu Lys Leu Asn Ile Glu 
                565                 570                 575     


Gly Thr Glu Lys Gly Asn Cys Gly Lys Asp Lys Asp Thr Trp Ile Gln 
            580                 585                 590         


Cys Asn Lys Arg Asp Val Leu Cys Gly Tyr Leu Leu Cys Thr Asn Ile 
        595                 600                 605             


Gly Asn Ile Pro Arg Leu Gly Glu Leu Asp Gly Glu Ile Thr Ser Thr 
    610                 615                 620                 


Leu Val Val Gln Gln Gly Arg Thr Leu Asn Cys Ser Gly Gly His Val 
625                 630                 635                 640 


Lys Leu Glu Glu Asp Val Asp Leu Gly Tyr Val Glu Asp Gly Thr Pro 
                645                 650                 655     


Cys Gly Pro Gln Met Met Cys Leu Glu His Arg Cys Leu Pro Val Ala 
            660                 665                 670         


Ser Phe Asn Phe Ser Thr Cys Leu Ser Ser Lys Glu Gly Thr Ile Cys 
        675                 680                 685             


Ser Gly Asn Gly Val Cys Ser Asn Glu Leu Lys Cys Val Cys Asn Arg 
    690                 695                 700                 


His Trp Ile Gly Ser Asp Cys Asn Thr Tyr Phe Pro His Asn Asp Asp 
705                 710                 715                 720 


Ala Lys Thr Gly Ile Thr Leu Ser Gly Asn Gly Val Ala Gly Thr Asn 
                725                 730                 735     


Ile Ile Ile Gly Ile Ile Ala Gly Thr Ile Leu Val Leu Ala Leu Ile 
            740                 745                 750         


Leu Gly Ile Thr Ala Trp Gly Tyr Lys Asn Tyr Arg Glu Gln Arg Ser 
        755                 760                 765             


Asn Gly Leu Ser His Ser Trp Ser Glu Arg Ile Pro Asp Thr Lys His 
    770                 775                 780                 


Ile Ser Asp Ile Cys Glu Asn Gly Arg Pro Arg Ser Asn Ser Trp Gln 
785                 790                 795                 800 


Gly Asn Leu Gly Gly Asn Lys Lys Lys Ile Arg Gly Lys Arg Phe Arg 
                805                 810                 815     


Pro Arg Ser Asn Ser Thr Glu Tyr Leu Asn Pro Trp Phe Lys Arg Asp 
            820                 825                 830         


Tyr Asn Val Ala Lys Trp Val Glu Asp Val Asn Lys Asn Thr Glu Gly 
        835                 840                 845             


Pro Tyr Phe Arg Thr Leu Ser Pro Ala Lys Ser Pro Ser Ser Ser Thr 
    850                 855                 860                 


Gly Ser Ile Ala Ser Ser Arg Lys Tyr Pro Tyr Pro Met Pro Pro Leu 
865                 870                 875                 880 


Pro Asp Glu Asp Lys Lys Val Asn Arg Gln Ser Ala Arg Leu Trp Glu 
                885                 890                 895     


Thr Ser Ile 
            


<210>  267
<211>  870
<212>  PRT
<213>  Homo Sapiens

<400>  267

Met Gln Ala Ala Val Ala Val Ser Val Pro Phe Leu Leu Leu Cys Val 
1               5                   10                  15      


Leu Gly Thr Cys Pro Pro Ala Arg Cys Gly Gln Ala Gly Asp Ala Ser 
            20                  25                  30          


Leu Met Glu Leu Glu Lys Arg Lys Glu Asn Arg Phe Val Glu Arg Gln 
        35                  40                  45              


Ser Ile Val Pro Leu Arg Leu Ile Tyr Arg Ser Gly Gly Glu Asp Glu 
    50                  55                  60                  


Ser Arg His Asp Ala Leu Asp Thr Arg Val Arg Gly Asp Leu Gly Gly 
65                  70                  75                  80  


Pro Gln Leu Thr His Val Asp Gln Ala Ser Phe Gln Val Asp Ala Phe 
                85                  90                  95      


Gly Thr Ser Phe Ile Leu Asp Val Val Leu Asn His Asp Leu Leu Ser 
            100                 105                 110         


Ser Glu Tyr Ile Glu Arg His Ile Glu His Gly Gly Lys Thr Val Glu 
        115                 120                 125             


Val Lys Gly Gly Glu His Cys Tyr Tyr Gln Gly His Ile Arg Gly Asn 
    130                 135                 140                 


Pro Asp Ser Phe Val Ala Leu Ser Thr Cys His Gly Leu His Gly Met 
145                 150                 155                 160 


Phe Tyr Asp Gly Asn His Thr Tyr Leu Ile Glu Pro Glu Glu Asn Asp 
                165                 170                 175     


Thr Thr Gln Glu Asp Phe His Phe His Ser Val Tyr Lys Ser Arg Leu 
            180                 185                 190         


Phe Glu Phe Ser Leu Asp Asp Leu Pro Ser Glu Phe Gln Gln Val Asn 
        195                 200                 205             


Ile Thr Pro Ser Lys Phe Ile Leu Lys Pro Arg Pro Lys Arg Ser Lys 
    210                 215                 220                 


Arg Gln Leu Arg Arg Tyr Pro Arg Asn Val Glu Glu Glu Thr Lys Tyr 
225                 230                 235                 240 


Ile Glu Leu Met Ile Val Asn Asp His Leu Met Phe Lys Lys His Arg 
                245                 250                 255     


Leu Ser Val Val His Thr Asn Thr Tyr Ala Lys Ser Val Val Asn Met 
            260                 265                 270         


Ala Asp Leu Ile Tyr Lys Asp Gln Leu Lys Thr Arg Ile Val Leu Val 
        275                 280                 285             


Ala Met Glu Thr Trp Ala Thr Asp Asn Lys Phe Ala Ile Ser Glu Asn 
    290                 295                 300                 


Pro Leu Ile Thr Leu Arg Glu Phe Met Lys Tyr Arg Arg Asp Phe Ile 
305                 310                 315                 320 


Lys Glu Lys Ser Asp Ala Val His Leu Phe Ser Gly Ser Gln Phe Glu 
                325                 330                 335     


Ser Ser Arg Ser Gly Ala Ala Tyr Ile Gly Gly Ile Cys Ser Leu Leu 
            340                 345                 350         


Lys Gly Gly Gly Val Asn Glu Phe Gly Lys Thr Asp Leu Met Ala Val 
        355                 360                 365             


Thr Leu Ala Gln Ser Leu Ala His Asn Ile Gly Ile Ile Ser Asp Lys 
    370                 375                 380                 


Arg Lys Leu Ala Ser Gly Glu Cys Lys Cys Glu Asp Thr Trp Ser Gly 
385                 390                 395                 400 


Cys Ile Met Gly Asp Thr Gly Tyr Tyr Leu Pro Lys Lys Phe Thr Gln 
                405                 410                 415     


Cys Asn Ile Glu Glu Tyr His Asp Phe Leu Asn Ser Gly Gly Gly Ala 
            420                 425                 430         


Cys Leu Phe Asn Lys Pro Ser Lys Leu Leu Asp Pro Pro Glu Cys Gly 
        435                 440                 445             


Asn Gly Phe Ile Glu Thr Gly Glu Glu Cys Asp Cys Gly Thr Pro Ala 
    450                 455                 460                 


Glu Cys Val Leu Glu Gly Ala Glu Cys Cys Lys Lys Cys Thr Leu Thr 
465                 470                 475                 480 


Gln Asp Ser Gln Cys Ser Asp Gly Leu Cys Cys Lys Lys Cys Lys Phe 
                485                 490                 495     


Gln Pro Met Gly Thr Val Cys Arg Glu Ala Val Asn Asp Cys Asp Ile 
            500                 505                 510         


Arg Glu Thr Cys Ser Gly Asn Ser Ser Gln Cys Ala Pro Asn Ile His 
        515                 520                 525             


Lys Met Asp Gly Tyr Ser Cys Asp Gly Val Gln Gly Ile Cys Phe Gly 
    530                 535                 540                 


Gly Arg Cys Lys Thr Arg Asp Arg Gln Cys Lys Tyr Ile Trp Gly Gln 
545                 550                 555                 560 


Lys Val Thr Ala Ser Asp Lys Tyr Cys Tyr Glu Lys Leu Asn Ile Glu 
                565                 570                 575     


Gly Thr Glu Lys Gly Asn Cys Gly Lys Asp Lys Asp Thr Trp Ile Gln 
            580                 585                 590         


Cys Asn Lys Arg Asp Val Leu Cys Gly Tyr Leu Leu Cys Thr Asn Ile 
        595                 600                 605             


Gly Asn Ile Pro Arg Leu Gly Glu Leu Asp Gly Glu Ile Thr Ser Thr 
    610                 615                 620                 


Leu Val Val Gln Gln Gly Arg Thr Leu Asn Cys Ser Gly Gly His Val 
625                 630                 635                 640 


Lys Leu Glu Glu Asp Val Asp Leu Gly Tyr Val Glu Asp Gly Thr Pro 
                645                 650                 655     


Cys Gly Pro Gln Met Met Cys Leu Glu His Arg Cys Leu Pro Val Ala 
            660                 665                 670         


Ser Phe Asn Phe Ser Thr Cys Leu Ser Ser Lys Glu Gly Thr Ile Cys 
        675                 680                 685             


Ser Gly Asn Gly Val Cys Ser Asn Glu Leu Lys Cys Val Cys Asn Arg 
    690                 695                 700                 


His Trp Ile Gly Ser Asp Cys Asn Thr Tyr Phe Pro His Asn Asp Asp 
705                 710                 715                 720 


Ala Lys Thr Gly Ile Thr Leu Ser Gly Asn Gly Val Ala Gly Thr Asn 
                725                 730                 735     


Ile Ile Ile Gly Ile Ile Ala Gly Thr Ile Leu Val Leu Ala Leu Ile 
            740                 745                 750         


Leu Gly Ile Thr Ala Trp Gly Tyr Lys Asn Tyr Arg Glu Gln Arg Ser 
        755                 760                 765             


Asn Gly Leu Ser His Ser Trp Ser Glu Arg Ile Pro Asp Thr Lys His 
    770                 775                 780                 


Ile Ser Asp Ile Cys Glu Asn Gly Arg Pro Arg Ser Asn Ser Trp Gln 
785                 790                 795                 800 


Gly Asn Leu Gly Gly Asn Lys Lys Lys Ile Arg Gly Lys Arg Phe Arg 
                805                 810                 815     


Pro Arg Ser Asn Ser Thr Glu Thr Leu Ser Pro Ala Lys Ser Pro Ser 
            820                 825                 830         


Ser Ser Thr Gly Ser Ile Ala Ser Ser Arg Lys Tyr Pro Tyr Pro Met 
        835                 840                 845             


Pro Pro Leu Pro Asp Glu Asp Lys Lys Val Asn Arg Gln Ser Ala Arg 
    850                 855                 860                 


Leu Trp Glu Thr Ser Ile 
865                 870 


<210>  268
<211>  342
<212>  PRT
<213>  Homo Sapiens

<400>  268

Met Gln Ala Ala Val Ala Val Ser Val Pro Phe Leu Leu Leu Cys Val 
1               5                   10                  15      


Leu Gly Thr Cys Pro Pro Ala Arg Cys Gly Gln Ala Gly Asp Ala Ser 
            20                  25                  30          


Leu Met Glu Leu Glu Lys Arg Lys Glu Asn Arg Phe Val Glu Arg Gln 
        35                  40                  45              


Ser Ile Val Pro Leu Arg Leu Ile Tyr Arg Ser Gly Gly Glu Asp Glu 
    50                  55                  60                  


Ser Arg His Asp Ala Leu Asp Thr Arg Val Arg Gly Asp Leu Gly Gly 
65                  70                  75                  80  


Pro Gln Leu Thr His Val Asp Gln Ala Ser Phe Gln Val Asp Ala Phe 
                85                  90                  95      


Gly Thr Ser Phe Ile Leu Asp Val Val Leu Asn His Asp Leu Leu Ser 
            100                 105                 110         


Ser Glu Tyr Ile Glu Arg His Ile Glu His Gly Gly Lys Thr Val Glu 
        115                 120                 125             


Val Lys Gly Gly Glu His Cys Tyr Tyr Gln Gly His Ile Arg Gly Asn 
    130                 135                 140                 


Pro Asp Ser Phe Val Ala Leu Ser Thr Cys His Gly Leu His Gly Met 
145                 150                 155                 160 


Phe Tyr Asp Gly Asn His Thr Tyr Leu Ile Glu Pro Glu Glu Asn Asp 
                165                 170                 175     


Thr Thr Gln Glu Asp Phe His Phe His Ser Val Tyr Lys Ser Arg Leu 
            180                 185                 190         


Phe Glu Phe Ser Leu Asp Asp Leu Pro Ser Glu Phe Gln Gln Val Asn 
        195                 200                 205             


Ile Thr Pro Ser Lys Phe Ile Leu Lys Pro Arg Pro Lys Arg Ser Lys 
    210                 215                 220                 


Arg Gln Leu Arg Arg Tyr Pro Arg Asn Val Glu Glu Glu Thr Lys Tyr 
225                 230                 235                 240 


Ile Glu Leu Met Ile Val Asn Asp His Leu Met Phe Lys Lys His Arg 
                245                 250                 255     


Leu Ser Val Val His Thr Asn Thr Tyr Ala Lys Ser Val Val Asn Met 
            260                 265                 270         


Ala Asp Leu Ile Tyr Lys Asp Gln Leu Lys Thr Arg Ile Val Leu Val 
        275                 280                 285             


Ala Met Glu Thr Trp Ala Thr Asp Asn Lys Phe Ala Ile Ser Glu Asn 
    290                 295                 300                 


Pro Leu Ile Thr Leu Arg Glu Phe Met Lys Tyr Arg Arg Asp Phe Ile 
305                 310                 315                 320 


Lys Glu Lys Ser Asp Ala Val His Leu Phe Ser Tyr Val Thr Ser Val 
                325                 330                 335     


Met Met Tyr Tyr Phe Phe 
            340         


<210>  269
<211>  264
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  269

Xaa Cys Asn Arg His Trp Ile Gly Ser Asp Cys Asn Thr Tyr Phe Pro 
1               5                   10                  15      


His Asn Asp Asp Ala Lys Thr Gly Ile Thr Leu Ser Gly Asn Gly Val 
            20                  25                  30          


Ala Gly Thr Asn Ile Ile Ile Gly Ile Ile Ala Gly Thr Ile Leu Val 
        35                  40                  45              


Leu Ala Leu Ile Leu Gly Ile Thr Ala Trp Gly Tyr Lys Asn Tyr Arg 
    50                  55                  60                  


Glu Gln Arg Gln Leu Pro Gln Gly Asp Tyr Val Lys Lys Pro Gly Asp 
65                  70                  75                  80  


Gly Asp Ser Phe Tyr Ser Asp Ile Pro Pro Gly Val Ser Thr Asn Ser 
                85                  90                  95      


Ala Ser Ser Ser Lys Lys Arg Ser Ala Phe Leu Ser His Phe Gln Ile 
            100                 105                 110         


Ser Thr Cys Ser Ile Thr His Tyr Ser Ile Ser Gln Asn Ile Ser Leu 
        115                 120                 125             


Phe Cys Ser Arg Ser Asn Gly Leu Ser His Ser Trp Ser Glu Arg Ile 
    130                 135                 140                 


Pro Asp Thr Lys His Ile Ser Asp Ile Cys Glu Asn Gly Arg Pro Arg 
145                 150                 155                 160 


Ser Asn Ser Trp Gln Gly Asn Leu Gly Gly Asn Lys Lys Lys Ile Arg 
                165                 170                 175     


Gly Lys Arg Phe Arg Pro Arg Ser Asn Ser Thr Glu Tyr Leu Asn Pro 
            180                 185                 190         


Trp Phe Lys Arg Asp Tyr Asn Val Ala Lys Trp Val Glu Asp Val Asn 
        195                 200                 205             


Lys Asn Thr Glu Gly Pro Tyr Phe Arg Thr Leu Ser Pro Ala Lys Ser 
    210                 215                 220                 


Pro Ser Ser Ser Thr Gly Ser Ile Ala Ser Ser Arg Lys Tyr Pro Tyr 
225                 230                 235                 240 


Pro Met Pro Pro Leu Pro Asp Glu Asp Lys Lys Val Asn Arg Gln Ser 
                245                 250                 255     


Ala Arg Leu Trp Glu Thr Ser Ile 
            260                 


<210>  270
<211>  217
<212>  PRT
<213>  Homo Sapiens

<400>  270

Met Leu Gln Gly Leu Leu Pro Val Ser Leu Leu Leu Ser Val Ala Val 
1               5                   10                  15      


Ser Ala Ile Lys Glu Leu Pro Gly Val Lys Lys Tyr Glu Val Val Tyr 
            20                  25                  30          


Pro Ile Arg Leu His Pro Leu His Lys Arg Glu Ala Lys Glu Pro Glu 
        35                  40                  45              


Gln Gln Glu Gln Phe Glu Thr Glu Leu Lys Tyr Lys Met Thr Ile Asn 
    50                  55                  60                  


Gly Lys Ile Ala Val Leu Tyr Leu Lys Lys Asn Lys Asn Leu Leu Ala 
65                  70                  75                  80  


Pro Gly Tyr Thr Glu Thr Tyr Tyr Asn Ser Thr Gly Lys Glu Ile Thr 
                85                  90                  95      


Thr Ser Pro Gln Ile Met Asp Asp Cys Tyr Tyr Gln Gly His Ile Leu 
            100                 105                 110         


Asn Glu Lys Val Ser Asp Ala Ser Ile Ser Thr Cys Arg Gly Leu Arg 
        115                 120                 125             


Gly Tyr Phe Ser Gln Gly Asp Gln Arg Tyr Phe Ile Glu Pro Leu Ser 
    130                 135                 140                 


Pro Ile His Arg Asp Gly Gln Glu His Ala Leu Phe Lys Tyr Asn Pro 
145                 150                 155                 160 


Asp Glu Lys Asn Tyr Asp Ser Thr Cys Gly Met Asp Gly Val Leu Trp 
                165                 170                 175     


Ala His Asp Leu Gln Gln Asn Ile Ala Leu Pro Ala Thr Lys Leu Val 
            180                 185                 190         


Lys Leu Lys Asp Arg Lys Val Gln Glu His Glu Lys Tyr Ile Glu Tyr 
        195                 200                 205             


Tyr Leu Val Leu Asp Asn Gly Glu Phe 
    210                 215         


<210>  271
<211>  775
<212>  PRT
<213>  Homo Sapiens

<400>  271

Met Leu Gln Gly Leu Leu Pro Val Ser Leu Leu Leu Ser Val Ala Val 
1               5                   10                  15      


Ser Ala Ile Lys Glu Leu Pro Gly Val Lys Lys Tyr Glu Val Val Tyr 
            20                  25                  30          


Pro Ile Arg Leu His Pro Leu His Lys Arg Glu Ala Lys Glu Pro Glu 
        35                  40                  45              


Gln Gln Glu Gln Phe Glu Thr Glu Leu Lys Tyr Lys Met Thr Ile Asn 
    50                  55                  60                  


Gly Lys Ile Ala Val Leu Tyr Leu Lys Lys Asn Lys Asn Leu Leu Ala 
65                  70                  75                  80  


Pro Gly Tyr Thr Glu Thr Tyr Tyr Asn Ser Thr Gly Lys Glu Ile Thr 
                85                  90                  95      


Thr Ser Pro Gln Ile Met Asp Asp Cys Tyr Tyr Gln Gly His Ile Leu 
            100                 105                 110         


Asn Glu Lys Val Ser Asp Ala Ser Ile Ser Thr Cys Arg Gly Leu Arg 
        115                 120                 125             


Gly Tyr Phe Ser Gln Gly Asp Gln Arg Tyr Phe Ile Glu Pro Leu Ser 
    130                 135                 140                 


Pro Ile His Arg Asp Gly Gln Glu His Ala Leu Phe Lys Tyr Asn Pro 
145                 150                 155                 160 


Asp Glu Lys Asn Tyr Asp Ser Thr Cys Gly Met Asp Gly Val Leu Trp 
                165                 170                 175     


Ala His Asp Leu Gln Gln Asn Ile Ala Leu Pro Ala Thr Lys Leu Val 
            180                 185                 190         


Lys Leu Lys Asp Arg Lys Val Gln Glu His Glu Lys Tyr Ile Glu Tyr 
        195                 200                 205             


Tyr Leu Val Leu Asp Asn Gly Glu Phe Lys Arg Tyr Asn Glu Asn Gln 
    210                 215                 220                 


Asp Glu Ile Arg Lys Arg Val Phe Glu Met Ala Asn Tyr Val Asn Met 
225                 230                 235                 240 


Leu Tyr Lys Lys Leu Asn Thr His Val Ala Leu Val Gly Met Glu Ile 
                245                 250                 255     


Trp Thr Asp Lys Asp Lys Ile Lys Ile Thr Pro Asn Ala Ser Phe Thr 
            260                 265                 270         


Leu Glu Asn Phe Ser Lys Trp Arg Gly Ser Val Leu Ser Arg Arg Lys 
        275                 280                 285             


Arg His Asp Ile Ala Gln Leu Ile Thr Ala Thr Glu Leu Ala Gly Thr 
    290                 295                 300                 


Thr Val Gly Leu Ala Phe Met Ser Thr Met Cys Ser Pro Tyr Ser Val 
305                 310                 315                 320 


Gly Val Val Gln Asp His Ser Asp Asn Leu Leu Arg Val Ala Gly Thr 
                325                 330                 335     


Met Ala His Glu Met Gly His Asn Phe Gly Met Phe His Asp Asp Tyr 
            340                 345                 350         


Ser Cys Lys Cys Pro Ser Thr Ile Cys Val Met Asp Lys Ala Leu Ser 
        355                 360                 365             


Phe Tyr Ile Pro Thr Asp Phe Ser Ser Cys Ser Arg Leu Ser Tyr Asp 
    370                 375                 380                 


Lys Phe Phe Glu Asp Lys Leu Ser Asn Cys Leu Phe Asn Ala Pro Leu 
385                 390                 395                 400 


Pro Thr Asp Ile Ile Ser Thr Pro Ile Cys Gly Asn Gln Leu Val Glu 
                405                 410                 415     


Met Gly Glu Asp Cys Asp Cys Gly Thr Ser Glu Glu Cys Thr Asn Ile 
            420                 425                 430         


Cys Cys Asp Ala Lys Thr Cys Lys Ile Lys Ala Thr Phe Gln Cys Ala 
        435                 440                 445             


Leu Gly Glu Cys Cys Glu Lys Cys Gln Phe Lys Lys Ala Gly Met Val 
    450                 455                 460                 


Cys Arg Pro Ala Lys Asp Glu Cys Asp Leu Pro Glu Met Cys Asn Gly 
465                 470                 475                 480 


Lys Ser Gly Asn Cys Pro Asp Asp Arg Phe Gln Val Asn Gly Phe Pro 
                485                 490                 495     


Cys His His Gly Lys Gly His Cys Leu Met Gly Thr Cys Pro Thr Leu 
            500                 505                 510         


Gln Glu Gln Cys Thr Glu Leu Trp Gly Pro Gly Thr Glu Val Ala Asp 
        515                 520                 525             


Lys Ser Cys Tyr Asn Arg Asn Glu Gly Gly Ser Lys Tyr Gly Tyr Cys 
    530                 535                 540                 


Arg Arg Val Asp Asp Thr Leu Ile Pro Cys Lys Ala Asn Asp Thr Met 
545                 550                 555                 560 


Cys Gly Lys Leu Phe Cys Gln Gly Gly Ser Asp Asn Leu Pro Trp Lys 
                565                 570                 575     


Gly Arg Ile Val Thr Phe Leu Thr Cys Lys Thr Phe Asp Pro Glu Asp 
            580                 585                 590         


Thr Ser Gln Glu Ile Gly Met Val Ala Asn Gly Thr Lys Cys Gly Asp 
        595                 600                 605             


Asn Lys Val Cys Ile Asn Ala Glu Cys Val Asp Ile Glu Lys Ala Tyr 
    610                 615                 620                 


Lys Ser Thr Asn Cys Ser Ser Lys Cys Lys Gly His Ala Val Cys Asp 
625                 630                 635                 640 


His Glu Leu Gln Cys Gln Cys Glu Glu Gly Trp Ile Pro Pro Asp Cys 
                645                 650                 655     


Asp Asp Ser Ser Val Val Phe His Phe Ser Ile Val Val Gly Val Leu 
            660                 665                 670         


Phe Pro Met Ala Val Ile Phe Val Val Val Ala Met Val Ile Arg His 
        675                 680                 685             


Gln Ser Ser Arg Glu Lys Gln Lys Lys Asp Gln Arg Pro Leu Ser Thr 
    690                 695                 700                 


Thr Gly Thr Arg Pro His Lys Gln Lys Arg Lys Pro Gln Met Val Lys 
705                 710                 715                 720 


Ala Val Gln Pro Gln Glu Met Ser Gln Met Lys Pro His Val Tyr Asp 
                725                 730                 735     


Leu Pro Val Glu Gly Asn Glu Pro Pro Ala Ser Phe His Lys Asp Thr 
            740                 745                 750         


Asn Ala Leu Pro Pro Thr Val Phe Lys Asp Asn Pro Val Ser Thr Pro 
        755                 760                 765             


Lys Asp Ser Asn Pro Lys Ala 
    770                 775 


<210>  272
<211>  540
<212>  PRT
<213>  Homo Sapiens

<400>  272

Met Leu Gln Gly Leu Leu Pro Val Ser Leu Leu Leu Ser Val Ala Val 
1               5                   10                  15      


Ser Ala Ile Lys Glu Leu Pro Gly Val Lys Lys Tyr Glu Val Val Tyr 
            20                  25                  30          


Pro Ile Arg Leu His Pro Leu His Lys Arg Glu Ala Lys Glu Pro Glu 
        35                  40                  45              


Gln Gln Glu Gln Phe Glu Thr Glu Leu Lys Tyr Lys Met Thr Ile Asn 
    50                  55                  60                  


Gly Lys Ile Ala Val Leu Tyr Leu Lys Lys Asn Lys Asn Leu Leu Ala 
65                  70                  75                  80  


Pro Gly Tyr Thr Glu Thr Tyr Tyr Asn Ser Thr Gly Lys Glu Ile Thr 
                85                  90                  95      


Thr Ser Pro Gln Ile Met Asp Asp Cys Tyr Tyr Gln Gly His Ile Leu 
            100                 105                 110         


Asn Glu Lys Val Ser Asp Ala Ser Ile Ser Thr Cys Arg Gly Leu Arg 
        115                 120                 125             


Gly Tyr Phe Ser Gln Gly Asp Gln Arg Tyr Phe Ile Glu Pro Leu Ser 
    130                 135                 140                 


Pro Ile His Arg Asp Gly Gln Glu His Ala Leu Phe Lys Tyr Asn Pro 
145                 150                 155                 160 


Asp Glu Lys Asn Tyr Asp Ser Thr Cys Gly Met Asp Gly Val Leu Trp 
                165                 170                 175     


Ala His Asp Leu Gln Gln Asn Ile Ala Leu Pro Ala Thr Lys Leu Val 
            180                 185                 190         


Lys Leu Lys Asp Arg Lys Val Gln Glu His Glu Lys Tyr Ile Glu Tyr 
        195                 200                 205             


Tyr Leu Val Leu Asp Asn Gly Glu Phe Lys Arg Tyr Asn Glu Asn Gln 
    210                 215                 220                 


Asp Glu Ile Arg Lys Arg Val Phe Glu Met Ala Asn Tyr Val Asn Met 
225                 230                 235                 240 


Leu Tyr Lys Lys Leu Asn Thr His Val Ala Leu Val Gly Met Glu Ile 
                245                 250                 255     


Trp Thr Asp Lys Asp Lys Ile Lys Ile Thr Pro Asn Ala Ser Phe Thr 
            260                 265                 270         


Leu Glu Asn Phe Ser Lys Trp Arg Gly Ser Val Leu Ser Arg Arg Lys 
        275                 280                 285             


Arg His Asp Ile Ala Gln Leu Ile Thr Ala Thr Glu Leu Ala Gly Thr 
    290                 295                 300                 


Thr Val Gly Leu Ala Phe Met Ser Thr Met Cys Ser Pro Tyr Ser Val 
305                 310                 315                 320 


Gly Val Val Gln Asp His Ser Asp Asn Leu Leu Arg Val Ala Gly Thr 
                325                 330                 335     


Met Ala His Glu Met Gly His Asn Phe Gly Met Phe His Asp Asp Tyr 
            340                 345                 350         


Ser Cys Lys Cys Pro Ser Thr Ile Cys Val Met Asp Lys Ala Leu Ser 
        355                 360                 365             


Phe Tyr Ile Pro Thr Asp Phe Ser Ser Cys Ser Arg Leu Ser Tyr Asp 
    370                 375                 380                 


Lys Phe Phe Glu Asp Lys Leu Ser Asn Cys Leu Phe Asn Ala Pro Leu 
385                 390                 395                 400 


Pro Thr Asp Ile Ile Ser Thr Pro Ile Cys Gly Asn Gln Leu Val Glu 
                405                 410                 415     


Met Gly Glu Asp Cys Asp Cys Gly Thr Ser Glu Glu Cys Thr Asn Ile 
            420                 425                 430         


Cys Cys Asp Ala Lys Thr Cys Lys Ile Lys Ala Thr Phe Gln Cys Ala 
        435                 440                 445             


Leu Gly Glu Cys Cys Glu Lys Cys Gln Phe Lys Lys Ala Gly Met Val 
    450                 455                 460                 


Cys Arg Pro Ala Lys Asp Glu Cys Asp Leu Pro Glu Met Cys Asn Gly 
465                 470                 475                 480 


Lys Ser Gly Asn Cys Pro Asp Asp Arg Phe Gln Val Asn Gly Phe Pro 
                485                 490                 495     


Cys His His Gly Lys Gly His Cys Leu Met Gly Thr Cys Pro Thr Leu 
            500                 505                 510         


Gln Glu Gln Cys Thr Glu Leu Trp Gly Pro Gly Arg Arg Thr Asn Pro 
        515                 520                 525             


Phe Pro Cys Ala Cys Ala Lys Glu Asn His Phe Arg 
    530                 535                 540 


<210>  273
<211>  58
<212>  PRT
<213>  Homo Sapiens

<400>  273

Met Leu Gln Gly Leu Leu Pro Val Ser Leu Leu Leu Ser Val Ala Val 
1               5                   10                  15      


Ser Ala Ile Lys Glu Leu Pro Gly Val Lys Lys Tyr Glu Val Val Tyr 
            20                  25                  30          


Pro Ile Arg Leu His Pro Leu His Lys Arg Glu Ala Lys Glu Pro Glu 
        35                  40                  45              


Gln Gln Phe Leu Ser Ser Met Lys Ile Ser 
    50                  55              


<210>  274
<211>  387
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  274

Xaa Phe Tyr Ile Pro Thr Asp Phe Ser Ser Cys Ser Arg Leu Ser Tyr 
1               5                   10                  15      


Asp Lys Phe Phe Glu Asp Lys Leu Ser Asn Cys Leu Phe Asn Ala Pro 
            20                  25                  30          


Leu Pro Thr Asp Ile Ile Ser Thr Pro Ile Cys Gly Asn Gln Leu Val 
        35                  40                  45              


Glu Met Gly Glu Asp Cys Asp Cys Gly Thr Ser Glu Glu Cys Thr Asn 
    50                  55                  60                  


Ile Cys Cys Asp Ala Lys Thr Cys Lys Ile Lys Ala Thr Phe Gln Cys 
65                  70                  75                  80  


Ala Leu Gly Glu Cys Cys Glu Lys Cys Gln Phe Lys Lys Ala Gly Met 
                85                  90                  95      


Val Cys Arg Pro Ala Lys Asp Glu Cys Asp Leu Pro Glu Met Cys Asn 
            100                 105                 110         


Gly Lys Ser Gly Asn Cys Pro Asp Asp Arg Phe Gln Val Asn Gly Phe 
        115                 120                 125             


Pro Cys His His Gly Lys Gly His Cys Leu Met Gly Thr Cys Pro Thr 
    130                 135                 140                 


Leu Gln Glu Gln Cys Thr Glu Leu Trp Gly Pro Gly Thr Glu Val Ala 
145                 150                 155                 160 


Asp Lys Ser Cys Tyr Asn Arg Asn Glu Gly Gly Ser Lys Tyr Gly Tyr 
                165                 170                 175     


Cys Arg Arg Val Asp Asp Thr Leu Ile Pro Cys Lys Ala Asn Asp Thr 
            180                 185                 190         


Met Cys Gly Lys Leu Phe Cys Gln Gly Gly Ser Asp Asn Leu Pro Trp 
        195                 200                 205             


Lys Gly Arg Ile Val Thr Phe Leu Thr Cys Lys Thr Phe Asp Pro Glu 
    210                 215                 220                 


Asp Thr Ser Gln Glu Ile Gly Met Val Ala Asn Gly Thr Lys Cys Gly 
225                 230                 235                 240 


Asp Asn Lys Val Cys Ile Asn Ala Glu Cys Val Asp Ile Glu Lys Ala 
                245                 250                 255     


Tyr Lys Ser Thr Asn Cys Ser Ser Lys Cys Lys Gly His Ala Val Cys 
            260                 265                 270         


Asp His Glu Leu Gln Cys Gln Cys Glu Glu Gly Trp Ile Pro Pro Asp 
        275                 280                 285             


Cys Asp Asp Ser Ser Val Val Phe His Phe Ser Ile Val Val Gly Val 
    290                 295                 300                 


Leu Phe Pro Met Ala Val Ile Phe Val Val Val Ala Met Val Ile Arg 
305                 310                 315                 320 


His Gln Ser Ser Arg Glu Lys Gln Lys Lys Asp Gln Arg Pro Leu Ser 
                325                 330                 335     


Thr Thr Gly Thr Arg Pro His Lys Gln Lys Arg Lys Pro Gln Met Val 
            340                 345                 350         


Lys Ala Val Gln Pro Gln Glu Met Ser Gln Met Lys Pro His Val Tyr 
        355                 360                 365             


Asp Leu Pro Val Glu Gly Asn Glu Pro Pro Ala Ser Phe Asp Ser Asn 
    370                 375                 380                 


Pro Lys Ala 
385         


<210>  275
<211>  174
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  275

Xaa Lys Gly Arg Ile Val Thr Phe Leu Thr Cys Lys Thr Phe Asp Pro 
1               5                   10                  15      


Glu Asp Thr Ser Gln Glu Ile Gly Met Val Ala Asn Gly Thr Lys Cys 
            20                  25                  30          


Gly Asp Asn Lys Val Cys Ile Asn Ala Glu Cys Val Asp Ile Glu Lys 
        35                  40                  45              


Ala Tyr Lys Ser Thr Asn Cys Ser Ser Lys Cys Lys Gly His Ala Val 
    50                  55                  60                  


Cys Asp His Glu Leu Gln Cys Gln Cys Glu Glu Gly Trp Ile Pro Pro 
65                  70                  75                  80  


Asp Cys Asp Asp Ser Ser Val Val Phe His Phe Ser Ile Val Val Gly 
                85                  90                  95      


Val Leu Phe Pro Met Ala Val Ile Phe Val Val Val Ala Met Val Ile 
            100                 105                 110         


Arg His Gln Ser Ser Arg Glu Lys Gln Lys Lys Asp Gln Arg Pro Leu 
        115                 120                 125             


Ser Thr Thr Gly Thr Arg Pro His Lys Gln Lys Arg Lys Pro Gln Met 
    130                 135                 140                 


Val Lys Ala Val Gln Pro Gln Glu Val Asn Tyr Ile Val Trp Ala Val 
145                 150                 155                 160 


Ile Thr Met Ala Pro Leu Cys Val Ser Leu Thr Leu Leu Ser 
                165                 170                 


<210>  276
<211>  14
<212>  PRT
<213>  Homo Sapiens

<400>  276

Met Lys Met Leu Leu Leu Leu His Cys Leu Gly Val Phe Leu 
1               5                   10                  


<210>  277
<211>  44
<212>  PRT
<213>  Homo Sapiens

<400>  277

Met Lys Met Leu Leu Leu Leu His Cys Leu Gly Val Phe Leu Ser Cys 
1               5                   10                  15      


Ser Gly His Ile Gln Asp Glu His Pro Gln Tyr His Ser Pro Pro Asp 
            20                  25                  30          


Val Val Ile Pro Val Arg Ile Thr Gly Thr Thr Arg 
        35                  40                  


<210>  278
<211>  90
<212>  PRT
<213>  Homo Sapiens

<400>  278

Met Lys Met Leu Leu Leu Leu His Cys Leu Gly Val Phe Leu Ser Cys 
1               5                   10                  15      


Ser Gly His Ile Gln Asp Glu His Pro Gln Tyr His Ser Pro Pro Asp 
            20                  25                  30          


Val Val Ile Pro Val Arg Ile Thr Gly Thr Thr Arg Gly Met Thr Pro 
        35                  40                  45              


Pro Gly Trp Leu Ser Tyr Ile Leu Pro Phe Gly Gly Gln Lys His Ile 
    50                  55                  60                  


Ile His Ile Lys Val Lys Lys Leu Leu Phe Ser Lys His Leu Pro Val 
65                  70                  75                  80  


Phe Thr Tyr Thr Asp Gln Gly Ala Ile Leu 
                85                  90  


<210>  279
<211>  820
<212>  PRT
<213>  Homo Sapiens

<400>  279

Met Lys Met Leu Leu Leu Leu His Cys Leu Gly Val Phe Leu Ser Cys 
1               5                   10                  15      


Ser Gly His Ile Gln Asp Glu His Pro Gln Tyr His Ser Pro Pro Asp 
            20                  25                  30          


Val Val Ile Pro Val Arg Ile Thr Gly Thr Thr Arg Gly Met Thr Pro 
        35                  40                  45              


Pro Gly Trp Leu Ser Tyr Ile Leu Pro Phe Gly Gly Gln Lys His Ile 
    50                  55                  60                  


Ile His Ile Lys Val Lys Lys Leu Leu Phe Ser Lys His Leu Pro Val 
65                  70                  75                  80  


Phe Thr Tyr Thr Asp Gln Gly Ala Ile Leu Glu Asp Gln Pro Phe Val 
                85                  90                  95      


Gln Asn Asn Cys Tyr Tyr His Gly Tyr Val Glu Gly Asp Pro Glu Ser 
            100                 105                 110         


Leu Val Ser Leu Ser Thr Cys Phe Gly Gly Phe Gln Gly Ile Leu Gln 
        115                 120                 125             


Ile Asn Asp Phe Ala Tyr Glu Ile Lys Pro Leu Ala Phe Ser Thr Thr 
    130                 135                 140                 


Phe Glu His Leu Val Tyr Lys Met Asp Ser Glu Glu Lys Gln Phe Ser 
145                 150                 155                 160 


Thr Met Arg Ser Gly Phe Met Gln Asn Glu Ile Thr Cys Arg Met Glu 
                165                 170                 175     


Phe Glu Glu Ile Asp Asn Ser Thr Gln Lys Gln Ser Ser Tyr Val Gly 
            180                 185                 190         


Trp Trp Ile His Phe Arg Ile Val Glu Ile Val Val Val Ile Asp Asn 
        195                 200                 205             


Tyr Leu Tyr Ile Arg Tyr Glu Arg Asn Asp Ser Lys Leu Leu Glu Asp 
    210                 215                 220                 


Leu Tyr Val Ile Val Asn Ile Val Asp Ser Ile Leu Asp Val Ile Gly 
225                 230                 235                 240 


Val Lys Val Leu Leu Phe Gly Leu Glu Ile Trp Thr Asn Lys Asn Leu 
                245                 250                 255     


Ile Val Val Asp Asp Val Arg Lys Ser Val His Leu Tyr Cys Lys Trp 
            260                 265                 270         


Lys Ser Glu Asn Ile Thr Pro Arg Met Gln His Asp Thr Ser His Leu 
        275                 280                 285             


Phe Thr Thr Leu Gly Leu Arg Gly Leu Ser Gly Ile Gly Ala Phe Arg 
    290                 295                 300                 


Gly Met Cys Thr Pro His Arg Ser Cys Ala Ile Val Thr Phe Met Asn 
305                 310                 315                 320 


Lys Thr Leu Gly Thr Phe Ser Ile Ala Val Ala His His Leu Gly His 
                325                 330                 335     


Asn Leu Gly Met Asn His Asp Glu Asp Thr Cys Arg Cys Ser Gln Pro 
            340                 345                 350         


Arg Cys Ile Met His Glu Gly Asn Pro Pro Ile Thr Lys Phe Ser Asn 
        355                 360                 365             


Cys Ser Tyr Gly Asp Phe Trp Glu Tyr Thr Val Glu Arg Thr Lys Cys 
    370                 375                 380                 


Leu Leu Glu Thr Val His Thr Lys Asp Ile Phe Asn Val Lys Arg Cys 
385                 390                 395                 400 


Gly Asn Gly Val Val Glu Glu Gly Glu Glu Cys Asp Cys Gly Pro Leu 
                405                 410                 415     


Lys His Cys Ala Lys Asp Pro Cys Cys Leu Ser Asn Cys Thr Leu Thr 
            420                 425                 430         


Asp Gly Ser Thr Cys Ala Phe Gly Leu Cys Cys Lys Asp Cys Lys Phe 
        435                 440                 445             


Leu Pro Ser Gly Lys Val Cys Arg Lys Glu Val Asn Glu Cys Asp Leu 
    450                 455                 460                 


Pro Glu Trp Cys Asn Gly Thr Ser His Lys Cys Pro Asp Asp Phe Tyr 
465                 470                 475                 480 


Val Glu Asp Gly Ile Pro Cys Lys Glu Arg Gly Tyr Cys Tyr Glu Lys 
                485                 490                 495     


Ser Cys His Asp Arg Asn Glu Gln Cys Arg Arg Ile Phe Gly Ala Gly 
            500                 505                 510         


Ala Asn Thr Ala Ser Glu Thr Cys Tyr Lys Glu Leu Asn Thr Leu Gly 
        515                 520                 525             


Asp Arg Val Gly His Cys Gly Ile Lys Asn Ala Thr Tyr Ile Lys Cys 
    530                 535                 540                 


Asn Ile Ser Asp Val Gln Cys Gly Arg Ile Gln Cys Glu Asn Val Thr 
545                 550                 555                 560 


Glu Ile Pro Asn Met Ser Asp His Thr Thr Val His Trp Ala Arg Phe 
                565                 570                 575     


Asn Asp Ile Met Cys Trp Ser Thr Asp Tyr His Leu Gly Met Lys Gly 
            580                 585                 590         


Pro Asp Ile Gly Glu Val Lys Asp Gly Thr Glu Cys Gly Ile Asp His 
        595                 600                 605             


Ile Cys Ile His Arg His Cys Val His Ile Thr Ile Leu Asn Ser Asn 
    610                 615                 620                 


Cys Ser Pro Ala Phe Cys Asn Lys Arg Gly Ile Cys Asn Asn Lys His 
625                 630                 635                 640 


His Cys His Cys Asn Tyr Leu Trp Asp Pro Pro Asn Cys Leu Ile Lys 
                645                 650                 655     


Gly Tyr Gly Gly Ser Val Asp Ser Gly Pro Pro Pro Lys Arg Lys Lys 
            660                 665                 670         


Lys Lys Lys Phe Cys Tyr Leu Cys Ile Leu Leu Leu Ile Val Leu Phe 
        675                 680                 685             


Ile Leu Leu Cys Cys Leu Tyr Arg Leu Cys Lys Lys Ser Lys Pro Ile 
    690                 695                 700                 


Lys Lys Gln Gln Asp Val Gln Thr Pro Ser Ala Lys Glu Glu Glu Lys 
705                 710                 715                 720 


Ile Gln Arg Arg Pro His Glu Leu Pro Pro Gln Ser Gln Pro Trp Val 
                725                 730                 735     


Met Pro Ser Gln Ser Gln Pro Pro Val Thr Pro Ser Gln Ser His Pro 
            740                 745                 750         


Gln Val Met Pro Ser Gln Ser Gln Pro Pro Val Thr Pro Ser Gln Ser 
        755                 760                 765             


Gln Pro Arg Val Met Pro Ser Gln Ser Gln Pro Pro Val Met Pro Ser 
    770                 775                 780                 


Gln Ser His Pro Gln Leu Thr Pro Ser Gln Ser Gln Pro Pro Val Thr 
785                 790                 795                 800 


Pro Ser Gln Arg Gln Pro Gln Leu Met Pro Ser Gln Ser Gln Pro Pro 
                805                 810                 815     


Val Thr Pro Ser 
            820 


<210>  280
<211>  820
<212>  PRT
<213>  Homo Sapiens

<400>  280

Met Lys Met Leu Leu Leu Leu His Cys Leu Gly Val Phe Leu Ser Cys 
1               5                   10                  15      


Ser Gly His Ile Gln Asp Glu His Pro Gln Tyr His Ser Pro Pro Asp 
            20                  25                  30          


Val Val Ile Pro Val Arg Ile Thr Gly Thr Thr Arg Gly Met Thr Pro 
        35                  40                  45              


Pro Gly Trp Leu Ser Tyr Ile Leu Pro Phe Gly Gly Gln Lys His Ile 
    50                  55                  60                  


Ile His Ile Lys Val Lys Lys Leu Leu Phe Ser Lys His Leu Pro Val 
65                  70                  75                  80  


Phe Thr Tyr Thr Asp Gln Gly Ala Ile Leu Glu Asp Gln Pro Phe Val 
                85                  90                  95      


Gln Asn Asn Cys Tyr Tyr His Gly Tyr Val Glu Gly Asp Pro Glu Ser 
            100                 105                 110         


Leu Val Ser Leu Ser Thr Cys Phe Gly Gly Phe Gln Gly Ile Leu Gln 
        115                 120                 125             


Ile Asn Asp Phe Ala Tyr Glu Ile Lys Pro Leu Ala Phe Ser Thr Thr 
    130                 135                 140                 


Phe Glu His Leu Val Tyr Lys Met Asp Ser Glu Glu Lys Gln Phe Ser 
145                 150                 155                 160 


Thr Met Arg Ser Gly Phe Met Gln Asn Glu Ile Thr Cys Arg Met Glu 
                165                 170                 175     


Phe Glu Glu Ile Asp Asn Ser Thr Gln Lys Gln Ser Ser Tyr Val Gly 
            180                 185                 190         


Trp Trp Ile His Phe Arg Ile Val Glu Ile Val Val Val Ile Asp Asn 
        195                 200                 205             


Tyr Leu Tyr Ile Arg Tyr Glu Arg Asn Asp Ser Lys Leu Leu Glu Asp 
    210                 215                 220                 


Leu Tyr Val Ile Val Asn Ile Val Asp Ser Ile Leu Asp Val Ile Gly 
225                 230                 235                 240 


Val Lys Val Leu Leu Phe Gly Leu Glu Ile Trp Thr Asn Lys Asn Leu 
                245                 250                 255     


Ile Val Val Asp Asp Val Arg Lys Ser Val His Leu Tyr Cys Lys Trp 
            260                 265                 270         


Lys Ser Glu Asn Ile Thr Pro Arg Met Gln His Asp Thr Ser His Leu 
        275                 280                 285             


Phe Thr Thr Leu Gly Leu Arg Gly Leu Ser Gly Ile Gly Ala Phe Arg 
    290                 295                 300                 


Gly Met Cys Thr Pro His Arg Ser Cys Ala Ile Val Thr Phe Met Asn 
305                 310                 315                 320 


Lys Thr Leu Gly Thr Phe Ser Ile Ala Val Ala His His Leu Gly His 
                325                 330                 335     


Asn Leu Gly Met Asn His Asp Glu Asp Thr Cys Arg Cys Ser Gln Pro 
            340                 345                 350         


Arg Cys Ile Met His Glu Gly Asn Pro Pro Ile Thr Lys Phe Ser Asn 
        355                 360                 365             


Cys Ser Tyr Gly Asp Phe Trp Glu Tyr Thr Val Glu Arg Thr Lys Cys 
    370                 375                 380                 


Leu Leu Glu Thr Val His Thr Lys Asp Ile Phe Asn Val Lys Arg Cys 
385                 390                 395                 400 


Gly Asn Gly Val Val Glu Glu Gly Glu Glu Cys Asp Cys Gly Pro Leu 
                405                 410                 415     


Lys His Cys Ala Lys Asp Pro Cys Cys Leu Ser Asn Cys Thr Leu Thr 
            420                 425                 430         


Asp Gly Ser Thr Cys Ala Phe Gly Leu Cys Cys Lys Asp Cys Lys Phe 
        435                 440                 445             


Leu Pro Ser Gly Lys Val Cys Arg Lys Glu Val Asn Glu Cys Asp Leu 
    450                 455                 460                 


Pro Glu Trp Cys Asn Gly Thr Ser His Lys Cys Pro Asp Asp Phe Tyr 
465                 470                 475                 480 


Val Glu Asp Gly Ile Pro Cys Lys Glu Arg Gly Tyr Cys Tyr Glu Lys 
                485                 490                 495     


Ser Cys His Asp Arg Asn Glu Gln Cys Arg Arg Ile Phe Gly Ala Gly 
            500                 505                 510         


Ala Asn Thr Ala Ser Glu Thr Cys Tyr Lys Glu Leu Asn Thr Leu Gly 
        515                 520                 525             


Asp Arg Val Gly His Cys Gly Ile Lys Asn Ala Thr Tyr Ile Lys Cys 
    530                 535                 540                 


Asn Ile Ser Asp Val Gln Cys Gly Arg Ile Gln Cys Glu Asn Val Thr 
545                 550                 555                 560 


Glu Ile Pro Asn Met Ser Asp His Thr Thr Val His Trp Ala Arg Phe 
                565                 570                 575     


Asn Asp Ile Met Cys Trp Ser Thr Asp Tyr His Leu Gly Met Lys Gly 
            580                 585                 590         


Pro Asp Ile Gly Glu Val Lys Asp Gly Thr Glu Cys Gly Ile Asp His 
        595                 600                 605             


Ile Cys Ile His Arg His Cys Val His Ile Thr Ile Leu Asn Ser Asn 
    610                 615                 620                 


Cys Ser Pro Ala Phe Cys Asn Lys Arg Gly Ile Cys Asn Asn Lys His 
625                 630                 635                 640 


His Cys His Cys Asn Tyr Leu Trp Asp Pro Pro Asn Cys Leu Ile Lys 
                645                 650                 655     


Gly Tyr Gly Gly Ser Val Asp Ser Gly Pro Pro Pro Lys Arg Lys Lys 
            660                 665                 670         


Lys Lys Lys Phe Cys Tyr Leu Cys Ile Leu Leu Leu Ile Val Leu Phe 
        675                 680                 685             


Ile Leu Leu Cys Cys Leu Tyr Arg Leu Cys Lys Lys Ser Lys Pro Ile 
    690                 695                 700                 


Lys Lys Gln Gln Asp Val Gln Thr Pro Ser Ala Lys Glu Glu Glu Lys 
705                 710                 715                 720 


Ile Gln Arg Arg Pro His Glu Leu Pro Pro Gln Ser Gln Pro Trp Val 
                725                 730                 735     


Met Pro Ser Gln Ser Gln Pro Pro Val Thr Pro Ser Gln Ser His Pro 
            740                 745                 750         


Gln Val Met Pro Ser Gln Ser Gln Pro Pro Val Thr Pro Ser Gln Ser 
        755                 760                 765             


Gln Pro Arg Val Met Pro Ser Gln Ser Gln Pro Pro Val Met Pro Ser 
    770                 775                 780                 


Gln Ser His Pro Gln Leu Thr Pro Ser Gln Ser Gln Pro Pro Val Thr 
785                 790                 795                 800 


Pro Ser Gln Arg Gln Pro Gln Leu Met Pro Ser Gln Ser Gln Pro Pro 
                805                 810                 815     


Val Thr Pro Ser 
            820 


<210>  281
<211>  820
<212>  PRT
<213>  Homo Sapiens

<400>  281

Met Lys Met Leu Leu Leu Leu His Cys Leu Gly Val Phe Leu Ser Cys 
1               5                   10                  15      


Ser Gly His Ile Gln Asp Glu His Pro Gln Tyr His Ser Pro Pro Asp 
            20                  25                  30          


Val Val Ile Pro Val Arg Ile Thr Gly Thr Thr Arg Gly Met Thr Pro 
        35                  40                  45              


Pro Gly Trp Leu Ser Tyr Ile Leu Pro Phe Gly Gly Gln Lys His Ile 
    50                  55                  60                  


Ile His Ile Lys Val Lys Lys Leu Leu Phe Ser Lys His Leu Pro Val 
65                  70                  75                  80  


Phe Thr Tyr Thr Asp Gln Gly Ala Ile Leu Glu Asp Gln Pro Phe Val 
                85                  90                  95      


Gln Asn Asn Cys Tyr Tyr His Gly Tyr Val Glu Gly Asp Pro Glu Ser 
            100                 105                 110         


Leu Val Ser Leu Ser Thr Cys Phe Gly Gly Phe Gln Gly Ile Leu Gln 
        115                 120                 125             


Ile Asn Asp Phe Ala Tyr Glu Ile Lys Pro Leu Ala Phe Ser Thr Thr 
    130                 135                 140                 


Phe Glu His Leu Val Tyr Lys Met Asp Ser Glu Glu Lys Gln Phe Ser 
145                 150                 155                 160 


Thr Met Arg Ser Gly Phe Met Gln Asn Glu Ile Thr Cys Arg Met Glu 
                165                 170                 175     


Phe Glu Glu Ile Asp Asn Ser Thr Gln Lys Gln Ser Ser Tyr Val Gly 
            180                 185                 190         


Trp Trp Ile His Phe Arg Ile Val Glu Ile Val Val Val Ile Asp Asn 
        195                 200                 205             


Tyr Leu Tyr Ile Arg Tyr Glu Arg Asn Asp Ser Lys Leu Leu Glu Asp 
    210                 215                 220                 


Leu Tyr Val Ile Val Asn Ile Val Asp Ser Ile Leu Asp Val Ile Gly 
225                 230                 235                 240 


Val Lys Val Leu Leu Phe Gly Leu Glu Ile Trp Thr Asn Lys Asn Leu 
                245                 250                 255     


Ile Val Val Asp Asp Val Arg Lys Ser Val His Leu Tyr Cys Lys Trp 
            260                 265                 270         


Lys Ser Glu Asn Ile Thr Pro Arg Met Gln His Asp Thr Ser His Leu 
        275                 280                 285             


Phe Thr Thr Leu Gly Leu Arg Gly Leu Ser Gly Ile Gly Ala Phe Arg 
    290                 295                 300                 


Gly Met Cys Thr Pro His Arg Ser Cys Ala Ile Val Thr Phe Met Asn 
305                 310                 315                 320 


Lys Thr Leu Gly Thr Phe Ser Ile Ala Val Ala His His Leu Gly His 
                325                 330                 335     


Asn Leu Gly Met Asn His Asp Glu Asp Thr Cys Arg Cys Ser Gln Pro 
            340                 345                 350         


Arg Cys Ile Met His Glu Gly Asn Pro Pro Ile Thr Lys Phe Ser Asn 
        355                 360                 365             


Cys Ser Tyr Gly Asp Phe Trp Glu Tyr Thr Val Glu Arg Thr Lys Cys 
    370                 375                 380                 


Leu Leu Glu Thr Val His Thr Lys Asp Ile Phe Asn Val Lys Arg Cys 
385                 390                 395                 400 


Gly Asn Gly Val Val Glu Glu Gly Glu Glu Cys Asp Cys Gly Pro Leu 
                405                 410                 415     


Lys His Cys Ala Lys Asp Pro Cys Cys Leu Ser Asn Cys Thr Leu Thr 
            420                 425                 430         


Asp Gly Ser Thr Cys Ala Phe Gly Leu Cys Cys Lys Asp Cys Lys Phe 
        435                 440                 445             


Leu Pro Ser Gly Lys Val Cys Arg Lys Glu Val Asn Glu Cys Asp Leu 
    450                 455                 460                 


Pro Glu Trp Cys Asn Gly Thr Ser His Lys Cys Pro Asp Asp Phe Tyr 
465                 470                 475                 480 


Val Glu Asp Gly Ile Pro Cys Lys Glu Arg Gly Tyr Cys Tyr Glu Lys 
                485                 490                 495     


Ser Cys His Asp Arg Asn Glu Gln Cys Arg Arg Ile Phe Gly Ala Gly 
            500                 505                 510         


Ala Asn Thr Ala Ser Glu Thr Cys Tyr Lys Glu Leu Asn Thr Leu Gly 
        515                 520                 525             


Asp Arg Val Gly His Cys Gly Ile Lys Asn Ala Thr Tyr Ile Lys Cys 
    530                 535                 540                 


Asn Ile Ser Asp Val Gln Cys Gly Arg Ile Gln Cys Glu Asn Val Thr 
545                 550                 555                 560 


Glu Ile Pro Asn Met Ser Asp His Thr Thr Val His Trp Ala Arg Phe 
                565                 570                 575     


Asn Asp Ile Met Cys Trp Ser Thr Asp Tyr His Leu Gly Met Lys Gly 
            580                 585                 590         


Pro Asp Ile Gly Glu Val Lys Asp Gly Thr Glu Cys Gly Ile Asp His 
        595                 600                 605             


Ile Cys Ile His Arg His Cys Val His Ile Thr Ile Leu Asn Ser Asn 
    610                 615                 620                 


Cys Ser Pro Ala Phe Cys Asn Lys Arg Gly Ile Cys Asn Asn Lys His 
625                 630                 635                 640 


His Cys His Cys Asn Tyr Leu Trp Asp Pro Pro Asn Cys Leu Ile Lys 
                645                 650                 655     


Gly Tyr Gly Gly Ser Val Asp Ser Gly Pro Pro Pro Lys Arg Lys Lys 
            660                 665                 670         


Lys Lys Lys Phe Cys Tyr Leu Cys Ile Leu Leu Leu Ile Val Leu Phe 
        675                 680                 685             


Ile Leu Leu Cys Cys Leu Tyr Arg Leu Cys Lys Lys Ser Lys Pro Ile 
    690                 695                 700                 


Lys Lys Gln Gln Asp Val Gln Thr Pro Ser Ala Lys Glu Glu Glu Lys 
705                 710                 715                 720 


Ile Gln Arg Arg Pro His Glu Leu Pro Pro Gln Ser Gln Pro Trp Val 
                725                 730                 735     


Met Pro Ser Gln Ser Gln Pro Pro Val Thr Pro Ser Gln Ser His Pro 
            740                 745                 750         


Gln Val Met Pro Ser Gln Ser Gln Pro Pro Val Thr Pro Ser Gln Ser 
        755                 760                 765             


Gln Pro Arg Val Met Pro Ser Gln Ser Gln Pro Pro Val Met Pro Ser 
    770                 775                 780                 


Gln Ser His Pro Gln Leu Thr Pro Ser Gln Ser Gln Pro Pro Val Thr 
785                 790                 795                 800 


Pro Ser Gln Arg Gln Pro Gln Leu Met Pro Ser Gln Ser Gln Pro Pro 
                805                 810                 815     


Val Thr Pro Ser 
            820 


<210>  282
<211>  820
<212>  PRT
<213>  Homo Sapiens

<400>  282

Met Lys Met Leu Leu Leu Leu His Cys Leu Gly Val Phe Leu Ser Cys 
1               5                   10                  15      


Ser Gly His Ile Gln Asp Glu His Pro Gln Tyr His Ser Pro Pro Asp 
            20                  25                  30          


Val Val Ile Pro Val Arg Ile Thr Gly Thr Thr Arg Gly Met Thr Pro 
        35                  40                  45              


Pro Gly Trp Leu Ser Tyr Ile Leu Pro Phe Gly Gly Gln Lys His Ile 
    50                  55                  60                  


Ile His Ile Lys Val Lys Lys Leu Leu Phe Ser Lys His Leu Pro Val 
65                  70                  75                  80  


Phe Thr Tyr Thr Asp Gln Gly Ala Ile Leu Glu Asp Gln Pro Phe Val 
                85                  90                  95      


Gln Asn Asn Cys Tyr Tyr His Gly Tyr Val Glu Gly Asp Pro Glu Ser 
            100                 105                 110         


Leu Val Ser Leu Ser Thr Cys Phe Gly Gly Phe Gln Gly Ile Leu Gln 
        115                 120                 125             


Ile Asn Asp Phe Ala Tyr Glu Ile Lys Pro Leu Ala Phe Ser Thr Thr 
    130                 135                 140                 


Phe Glu His Leu Val Tyr Lys Met Asp Ser Glu Glu Lys Gln Phe Ser 
145                 150                 155                 160 


Thr Met Arg Ser Gly Phe Met Gln Asn Glu Ile Thr Cys Arg Met Glu 
                165                 170                 175     


Phe Glu Glu Ile Asp Asn Ser Thr Gln Lys Gln Ser Ser Tyr Val Gly 
            180                 185                 190         


Trp Trp Ile His Phe Arg Ile Val Glu Ile Val Val Val Ile Asp Asn 
        195                 200                 205             


Tyr Leu Tyr Ile Arg Tyr Glu Arg Asn Asp Ser Lys Leu Leu Glu Asp 
    210                 215                 220                 


Leu Tyr Val Ile Val Asn Ile Val Asp Ser Ile Leu Asp Val Ile Gly 
225                 230                 235                 240 


Val Lys Val Leu Leu Phe Gly Leu Glu Ile Trp Thr Asn Lys Asn Leu 
                245                 250                 255     


Ile Val Val Asp Asp Val Arg Lys Ser Val His Leu Tyr Cys Lys Trp 
            260                 265                 270         


Lys Ser Glu Asn Ile Thr Pro Arg Met Gln His Asp Thr Ser His Leu 
        275                 280                 285             


Phe Thr Thr Leu Gly Leu Arg Gly Leu Ser Gly Ile Gly Ala Phe Arg 
    290                 295                 300                 


Gly Met Cys Thr Pro His Arg Ser Cys Ala Ile Val Thr Phe Met Asn 
305                 310                 315                 320 


Lys Thr Leu Gly Thr Phe Ser Ile Ala Val Ala His His Leu Gly His 
                325                 330                 335     


Asn Leu Gly Met Asn His Asp Glu Asp Thr Cys Arg Cys Ser Gln Pro 
            340                 345                 350         


Arg Cys Ile Met His Glu Gly Asn Pro Pro Ile Thr Lys Phe Ser Asn 
        355                 360                 365             


Cys Ser Tyr Gly Asp Phe Trp Glu Tyr Thr Val Glu Arg Thr Lys Cys 
    370                 375                 380                 


Leu Leu Glu Thr Val His Thr Lys Asp Ile Phe Asn Val Lys Arg Cys 
385                 390                 395                 400 


Gly Asn Gly Val Val Glu Glu Gly Glu Glu Cys Asp Cys Gly Pro Leu 
                405                 410                 415     


Lys His Cys Ala Lys Asp Pro Cys Cys Leu Ser Asn Cys Thr Leu Thr 
            420                 425                 430         


Asp Gly Ser Thr Cys Ala Phe Gly Leu Cys Cys Lys Asp Cys Lys Phe 
        435                 440                 445             


Leu Pro Ser Gly Lys Val Cys Arg Lys Glu Val Asn Glu Cys Asp Leu 
    450                 455                 460                 


Pro Glu Trp Cys Asn Gly Thr Ser His Lys Cys Pro Asp Asp Phe Tyr 
465                 470                 475                 480 


Val Glu Asp Gly Ile Pro Cys Lys Glu Arg Gly Tyr Cys Tyr Glu Lys 
                485                 490                 495     


Ser Cys His Asp Arg Asn Glu Gln Cys Arg Arg Ile Phe Gly Ala Gly 
            500                 505                 510         


Ala Asn Thr Ala Ser Glu Thr Cys Tyr Lys Glu Leu Asn Thr Leu Gly 
        515                 520                 525             


Asp Arg Val Gly His Cys Gly Ile Lys Asn Ala Thr Tyr Ile Lys Cys 
    530                 535                 540                 


Asn Ile Ser Asp Val Gln Cys Gly Arg Ile Gln Cys Glu Asn Val Thr 
545                 550                 555                 560 


Glu Ile Pro Asn Met Ser Asp His Thr Thr Val His Trp Ala Arg Phe 
                565                 570                 575     


Asn Asp Ile Met Cys Trp Ser Thr Asp Tyr His Leu Gly Met Lys Gly 
            580                 585                 590         


Pro Asp Ile Gly Glu Val Lys Asp Gly Thr Glu Cys Gly Ile Asp His 
        595                 600                 605             


Ile Cys Ile His Arg His Cys Val His Ile Thr Ile Leu Asn Ser Asn 
    610                 615                 620                 


Cys Ser Pro Ala Phe Cys Asn Lys Arg Gly Ile Cys Asn Asn Lys His 
625                 630                 635                 640 


His Cys His Cys Asn Tyr Leu Trp Asp Pro Pro Asn Cys Leu Ile Lys 
                645                 650                 655     


Gly Tyr Gly Gly Ser Val Asp Ser Gly Pro Pro Pro Lys Arg Lys Lys 
            660                 665                 670         


Lys Lys Lys Phe Cys Tyr Leu Cys Ile Leu Leu Leu Ile Val Leu Phe 
        675                 680                 685             


Ile Leu Leu Cys Cys Leu Tyr Arg Leu Cys Lys Lys Ser Lys Pro Ile 
    690                 695                 700                 


Lys Lys Gln Gln Asp Val Gln Thr Pro Ser Ala Lys Glu Glu Glu Lys 
705                 710                 715                 720 


Ile Gln Arg Arg Pro His Glu Leu Pro Pro Gln Ser Gln Pro Trp Val 
                725                 730                 735     


Met Pro Ser Gln Ser Gln Pro Pro Val Thr Pro Ser Gln Ser His Pro 
            740                 745                 750         


Gln Val Met Pro Ser Gln Ser Gln Pro Pro Val Thr Pro Ser Gln Ser 
        755                 760                 765             


Gln Pro Arg Val Met Pro Ser Gln Ser Gln Pro Pro Val Met Pro Ser 
    770                 775                 780                 


Gln Ser His Pro Gln Leu Thr Pro Ser Gln Ser Gln Pro Pro Val Thr 
785                 790                 795                 800 


Pro Ser Gln Arg Gln Pro Gln Leu Met Pro Ser Gln Ser Gln Pro Pro 
                805                 810                 815     


Val Thr Pro Ser 
            820 


<210>  283
<211>  820
<212>  PRT
<213>  Homo Sapiens

<400>  283

Met Lys Met Leu Leu Leu Leu His Cys Leu Gly Val Phe Leu Ser Cys 
1               5                   10                  15      


Ser Gly His Ile Gln Asp Glu His Pro Gln Tyr His Ser Pro Pro Asp 
            20                  25                  30          


Val Val Ile Pro Val Arg Ile Thr Gly Thr Thr Arg Gly Met Thr Pro 
        35                  40                  45              


Pro Gly Trp Leu Ser Tyr Ile Leu Pro Phe Gly Gly Gln Lys His Ile 
    50                  55                  60                  


Ile His Ile Lys Val Lys Lys Leu Leu Phe Ser Lys His Leu Pro Val 
65                  70                  75                  80  


Phe Thr Tyr Thr Asp Gln Gly Ala Ile Leu Glu Asp Gln Pro Phe Val 
                85                  90                  95      


Gln Asn Asn Cys Tyr Tyr His Gly Tyr Val Glu Gly Asp Pro Glu Ser 
            100                 105                 110         


Leu Val Ser Leu Ser Thr Cys Phe Gly Gly Phe Gln Gly Ile Leu Gln 
        115                 120                 125             


Ile Asn Asp Phe Ala Tyr Glu Ile Lys Pro Leu Ala Phe Ser Thr Thr 
    130                 135                 140                 


Phe Glu His Leu Val Tyr Lys Met Asp Ser Glu Glu Lys Gln Phe Ser 
145                 150                 155                 160 


Thr Met Arg Ser Gly Phe Met Gln Asn Glu Ile Thr Cys Arg Met Glu 
                165                 170                 175     


Phe Glu Glu Ile Asp Asn Ser Thr Gln Lys Gln Ser Ser Tyr Val Gly 
            180                 185                 190         


Trp Trp Ile His Phe Arg Ile Val Glu Ile Val Val Val Ile Asp Asn 
        195                 200                 205             


Tyr Leu Tyr Ile Arg Tyr Glu Arg Asn Asp Ser Lys Leu Leu Glu Asp 
    210                 215                 220                 


Leu Tyr Val Ile Val Asn Ile Val Asp Ser Ile Leu Asp Val Ile Gly 
225                 230                 235                 240 


Val Lys Val Leu Leu Phe Gly Leu Glu Ile Trp Thr Asn Lys Asn Leu 
                245                 250                 255     


Ile Val Val Asp Asp Val Arg Lys Ser Val His Leu Tyr Cys Lys Trp 
            260                 265                 270         


Lys Ser Glu Asn Ile Thr Pro Arg Met Gln His Asp Thr Ser His Leu 
        275                 280                 285             


Phe Thr Thr Leu Gly Leu Arg Gly Leu Ser Gly Ile Gly Ala Phe Arg 
    290                 295                 300                 


Gly Met Cys Thr Pro His Arg Ser Cys Ala Ile Val Thr Phe Met Asn 
305                 310                 315                 320 


Lys Thr Leu Gly Thr Phe Ser Ile Ala Val Ala His His Leu Gly His 
                325                 330                 335     


Asn Leu Gly Met Asn His Asp Glu Asp Thr Cys Arg Cys Ser Gln Pro 
            340                 345                 350         


Arg Cys Ile Met His Glu Gly Asn Pro Pro Ile Thr Lys Phe Ser Asn 
        355                 360                 365             


Cys Ser Tyr Gly Asp Phe Trp Glu Tyr Thr Val Glu Arg Thr Lys Cys 
    370                 375                 380                 


Leu Leu Glu Thr Val His Thr Lys Asp Ile Phe Asn Val Lys Arg Cys 
385                 390                 395                 400 


Gly Asn Gly Val Val Glu Glu Gly Glu Glu Cys Asp Cys Gly Pro Leu 
                405                 410                 415     


Lys His Cys Ala Lys Asp Pro Cys Cys Leu Ser Asn Cys Thr Leu Thr 
            420                 425                 430         


Asp Gly Ser Thr Cys Ala Phe Gly Leu Cys Cys Lys Asp Cys Lys Phe 
        435                 440                 445             


Leu Pro Ser Gly Lys Val Cys Arg Lys Glu Val Asn Glu Cys Asp Leu 
    450                 455                 460                 


Pro Glu Trp Cys Asn Gly Thr Ser His Lys Cys Pro Asp Asp Phe Tyr 
465                 470                 475                 480 


Val Glu Asp Gly Ile Pro Cys Lys Glu Arg Gly Tyr Cys Tyr Glu Lys 
                485                 490                 495     


Ser Cys His Asp Arg Asn Glu Gln Cys Arg Arg Ile Phe Gly Ala Gly 
            500                 505                 510         


Ala Asn Thr Ala Ser Glu Thr Cys Tyr Lys Glu Leu Asn Thr Leu Gly 
        515                 520                 525             


Asp Arg Val Gly His Cys Gly Ile Lys Asn Ala Thr Tyr Ile Lys Cys 
    530                 535                 540                 


Asn Ile Ser Asp Val Gln Cys Gly Arg Ile Gln Cys Glu Asn Val Thr 
545                 550                 555                 560 


Glu Ile Pro Asn Met Ser Asp His Thr Thr Val His Trp Ala Arg Phe 
                565                 570                 575     


Asn Asp Ile Met Cys Trp Ser Thr Asp Tyr His Leu Gly Met Lys Gly 
            580                 585                 590         


Pro Asp Ile Gly Glu Val Lys Asp Gly Thr Glu Cys Gly Ile Asp His 
        595                 600                 605             


Ile Cys Ile His Arg His Cys Val His Ile Thr Ile Leu Asn Ser Asn 
    610                 615                 620                 


Cys Ser Pro Ala Phe Cys Asn Lys Arg Gly Ile Cys Asn Asn Lys His 
625                 630                 635                 640 


His Cys His Cys Asn Tyr Leu Trp Asp Pro Pro Asn Cys Leu Ile Lys 
                645                 650                 655     


Gly Tyr Gly Gly Ser Val Asp Ser Gly Pro Pro Pro Lys Arg Lys Lys 
            660                 665                 670         


Lys Lys Lys Phe Cys Tyr Leu Cys Ile Leu Leu Leu Ile Val Leu Phe 
        675                 680                 685             


Ile Leu Leu Cys Cys Leu Tyr Arg Leu Cys Lys Lys Ser Lys Pro Ile 
    690                 695                 700                 


Lys Lys Gln Gln Asp Val Gln Thr Pro Ser Ala Lys Glu Glu Glu Lys 
705                 710                 715                 720 


Ile Gln Arg Arg Pro His Glu Leu Pro Pro Gln Ser Gln Pro Trp Val 
                725                 730                 735     


Met Pro Ser Gln Ser Gln Pro Pro Val Thr Pro Ser Gln Ser His Pro 
            740                 745                 750         


Gln Val Met Pro Ser Gln Ser Gln Pro Pro Val Thr Pro Ser Gln Ser 
        755                 760                 765             


Gln Pro Arg Val Met Pro Ser Gln Ser Gln Pro Pro Val Met Pro Ser 
    770                 775                 780                 


Gln Ser His Pro Gln Leu Thr Pro Ser Gln Ser Gln Pro Pro Val Thr 
785                 790                 795                 800 


Pro Ser Gln Arg Gln Pro Gln Leu Met Pro Ser Gln Ser Gln Pro Pro 
                805                 810                 815     


Val Thr Pro Ser 
            820 


<210>  284
<211>  820
<212>  PRT
<213>  Homo Sapiens

<400>  284

Met Lys Met Leu Leu Leu Leu His Cys Leu Gly Val Phe Leu Ser Cys 
1               5                   10                  15      


Ser Gly His Ile Gln Asp Glu His Pro Gln Tyr His Ser Pro Pro Asp 
            20                  25                  30          


Val Val Ile Pro Val Arg Ile Thr Gly Thr Thr Arg Gly Met Thr Pro 
        35                  40                  45              


Pro Gly Trp Leu Ser Tyr Ile Leu Pro Phe Gly Gly Gln Lys His Ile 
    50                  55                  60                  


Ile His Ile Lys Val Lys Lys Leu Leu Phe Ser Lys His Leu Pro Val 
65                  70                  75                  80  


Phe Thr Tyr Thr Asp Gln Gly Ala Ile Leu Glu Asp Gln Pro Phe Val 
                85                  90                  95      


Gln Asn Asn Cys Tyr Tyr His Gly Tyr Val Glu Gly Asp Pro Glu Ser 
            100                 105                 110         


Leu Val Ser Leu Ser Thr Cys Phe Gly Gly Phe Gln Gly Ile Leu Gln 
        115                 120                 125             


Ile Asn Asp Phe Ala Tyr Glu Ile Lys Pro Leu Ala Phe Ser Thr Thr 
    130                 135                 140                 


Phe Glu His Leu Val Tyr Lys Met Asp Ser Glu Glu Lys Gln Phe Ser 
145                 150                 155                 160 


Thr Met Arg Ser Gly Phe Met Gln Asn Glu Ile Thr Cys Arg Met Glu 
                165                 170                 175     


Phe Glu Glu Ile Asp Asn Ser Thr Gln Lys Gln Ser Ser Tyr Val Gly 
            180                 185                 190         


Trp Trp Ile His Phe Arg Ile Val Glu Ile Val Val Val Ile Asp Asn 
        195                 200                 205             


Tyr Leu Tyr Ile Arg Tyr Glu Arg Asn Asp Ser Lys Leu Leu Glu Asp 
    210                 215                 220                 


Leu Tyr Val Ile Val Asn Ile Val Asp Ser Ile Leu Asp Val Ile Gly 
225                 230                 235                 240 


Val Lys Val Leu Leu Phe Gly Leu Glu Ile Trp Thr Asn Lys Asn Leu 
                245                 250                 255     


Ile Val Val Asp Asp Val Arg Lys Ser Val His Leu Tyr Cys Lys Trp 
            260                 265                 270         


Lys Ser Glu Asn Ile Thr Pro Arg Met Gln His Asp Thr Ser His Leu 
        275                 280                 285             


Phe Thr Thr Leu Gly Leu Arg Gly Leu Ser Gly Ile Gly Ala Phe Arg 
    290                 295                 300                 


Gly Met Cys Thr Pro His Arg Ser Cys Ala Ile Val Thr Phe Met Asn 
305                 310                 315                 320 


Lys Thr Leu Gly Thr Phe Ser Ile Ala Val Ala His His Leu Gly His 
                325                 330                 335     


Asn Leu Gly Met Asn His Asp Glu Asp Thr Cys Arg Cys Ser Gln Pro 
            340                 345                 350         


Arg Cys Ile Met His Glu Gly Asn Pro Pro Ile Thr Lys Phe Ser Asn 
        355                 360                 365             


Cys Ser Tyr Gly Asp Phe Trp Glu Tyr Thr Val Glu Arg Thr Lys Cys 
    370                 375                 380                 


Leu Leu Glu Thr Val His Thr Lys Asp Ile Phe Asn Val Lys Arg Cys 
385                 390                 395                 400 


Gly Asn Gly Val Val Glu Glu Gly Glu Glu Cys Asp Cys Gly Pro Leu 
                405                 410                 415     


Lys His Cys Ala Lys Asp Pro Cys Cys Leu Ser Asn Cys Thr Leu Thr 
            420                 425                 430         


Asp Gly Ser Thr Cys Ala Phe Gly Leu Cys Cys Lys Asp Cys Lys Phe 
        435                 440                 445             


Leu Pro Ser Gly Lys Val Cys Arg Lys Glu Val Asn Glu Cys Asp Leu 
    450                 455                 460                 


Pro Glu Trp Cys Asn Gly Thr Ser His Lys Cys Pro Asp Asp Phe Tyr 
465                 470                 475                 480 


Val Glu Asp Gly Ile Pro Cys Lys Glu Arg Gly Tyr Cys Tyr Glu Lys 
                485                 490                 495     


Ser Cys His Asp Arg Asn Glu Gln Cys Arg Arg Ile Phe Gly Ala Gly 
            500                 505                 510         


Ala Asn Thr Ala Ser Glu Thr Cys Tyr Lys Glu Leu Asn Thr Leu Gly 
        515                 520                 525             


Asp Arg Val Gly His Cys Gly Ile Lys Asn Ala Thr Tyr Ile Lys Cys 
    530                 535                 540                 


Asn Ile Ser Asp Val Gln Cys Gly Arg Ile Gln Cys Glu Asn Val Thr 
545                 550                 555                 560 


Glu Ile Pro Asn Met Ser Asp His Thr Thr Val His Trp Ala Arg Phe 
                565                 570                 575     


Asn Asp Ile Met Cys Trp Ser Thr Asp Tyr His Leu Gly Met Lys Gly 
            580                 585                 590         


Pro Asp Ile Gly Glu Val Lys Asp Gly Thr Glu Cys Gly Ile Asp His 
        595                 600                 605             


Ile Cys Ile His Arg His Cys Val His Ile Thr Ile Leu Asn Ser Asn 
    610                 615                 620                 


Cys Ser Pro Ala Phe Cys Asn Lys Arg Gly Ile Cys Asn Asn Lys His 
625                 630                 635                 640 


His Cys His Cys Asn Tyr Leu Trp Asp Pro Pro Asn Cys Leu Ile Lys 
                645                 650                 655     


Gly Tyr Gly Gly Ser Val Asp Ser Gly Pro Pro Pro Lys Arg Lys Lys 
            660                 665                 670         


Lys Lys Lys Phe Cys Tyr Leu Cys Ile Leu Leu Leu Ile Val Leu Phe 
        675                 680                 685             


Ile Leu Leu Cys Cys Leu Tyr Arg Leu Cys Lys Lys Ser Lys Pro Ile 
    690                 695                 700                 


Lys Lys Gln Gln Asp Val Gln Thr Pro Ser Ala Lys Glu Glu Glu Lys 
705                 710                 715                 720 


Ile Gln Arg Arg Pro His Glu Leu Pro Pro Gln Ser Gln Pro Trp Val 
                725                 730                 735     


Met Pro Ser Gln Ser Gln Pro Pro Val Thr Pro Ser Gln Ser His Pro 
            740                 745                 750         


Gln Val Met Pro Ser Gln Ser Gln Pro Pro Val Thr Pro Ser Gln Ser 
        755                 760                 765             


Gln Pro Arg Val Met Pro Ser Gln Ser Gln Pro Pro Val Met Pro Ser 
    770                 775                 780                 


Gln Ser His Pro Gln Leu Thr Pro Ser Gln Ser Gln Pro Pro Val Thr 
785                 790                 795                 800 


Pro Ser Gln Arg Gln Pro Gln Leu Met Pro Ser Gln Ser Gln Pro Pro 
                805                 810                 815     


Val Thr Pro Ser 
            820 


<210>  285
<211>  787
<212>  PRT
<213>  Homo Sapiens

<400>  285

Met Phe Arg Leu Trp Leu Leu Leu Ala Gly Leu Cys Gly Leu Leu Ala 
1               5                   10                  15      


Ser Arg Pro Gly Phe Gln Asn Ser Leu Leu Gln Ile Val Ile Pro Glu 
            20                  25                  30          


Lys Ile Gln Thr Asn Thr Asn Asp Ser Ser Glu Ile Glu Tyr Glu Gln 
        35                  40                  45              


Ile Ser Tyr Ile Ile Pro Ile Asp Glu Lys Leu Tyr Thr Val His Leu 
    50                  55                  60                  


Lys Gln Arg Tyr Phe Leu Ala Asp Asn Phe Met Ile Tyr Leu Tyr Asn 
65                  70                  75                  80  


Gln Gly Ser Met Asn Thr Tyr Ser Ser Asp Ile Gln Thr Gln Cys Tyr 
                85                  90                  95      


Tyr Gln Gly Asn Ile Glu Gly Tyr Pro Asp Ser Met Val Thr Leu Ser 
            100                 105                 110         


Thr Cys Ser Gly Leu Arg Gly Ile Leu Gln Phe Glu Asn Val Ser Tyr 
        115                 120                 125             


Gly Ile Glu Pro Leu Glu Ser Ala Val Glu Phe Gln His Val Leu Tyr 
    130                 135                 140                 


Lys Leu Lys Asn Glu Asp Asn Asp Ile Ala Ile Phe Ile Asp Arg Ser 
145                 150                 155                 160 


Leu Lys Glu Gln Pro Met Asp Asp Asn Ile Phe Ile Ser Glu Lys Ser 
                165                 170                 175     


Glu Pro Ala Val Pro Asp Leu Phe Pro Leu Tyr Leu Glu Met His Ile 
            180                 185                 190         


Val Val Asp Lys Thr Leu Tyr Asp Tyr Trp Gly Ser Asp Ser Met Ile 
        195                 200                 205             


Val Thr Asn Lys Val Ile Glu Ile Val Gly Leu Ala Asn Ser Met Phe 
    210                 215                 220                 


Thr Gln Phe Lys Val Thr Ile Val Leu Ser Ser Leu Glu Leu Trp Ser 
225                 230                 235                 240 


Asp Glu Asn Lys Ile Ser Thr Val Gly Glu Ala Asp Glu Leu Leu Gln 
                245                 250                 255     


Lys Phe Leu Glu Trp Lys Gln Ser Tyr Leu Asn Leu Arg Pro His Asp 
            260                 265                 270         


Ile Ala Tyr Leu Leu Ile Tyr Met Asp Tyr Pro Arg Tyr Leu Gly Ala 
        275                 280                 285             


Val Phe Pro Gly Thr Met Cys Ile Thr Arg Tyr Ser Ala Gly Val Ala 
    290                 295                 300                 


Leu Tyr Pro Lys Glu Ile Thr Leu Glu Ala Phe Ala Val Ile Val Thr 
305                 310                 315                 320 


Gln Met Leu Ala Leu Ser Leu Gly Ile Ser Tyr Asp Asp Pro Lys Lys 
                325                 330                 335     


Cys Gln Cys Ser Glu Ser Thr Cys Ile Met Asn Pro Glu Val Val Gln 
            340                 345                 350         


Ser Asn Gly Val Lys Thr Phe Ser Ser Cys Ser Leu Arg Ser Phe Gln 
        355                 360                 365             


Asn Phe Ile Ser Asn Val Gly Val Lys Cys Leu Gln Asn Lys Pro Gln 
    370                 375                 380                 


Met Gln Lys Lys Ser Pro Lys Pro Val Cys Gly Asn Gly Arg Leu Glu 
385                 390                 395                 400 


Gly Asn Glu Ile Cys Asp Cys Gly Thr Glu Ala Gln Cys Gly Pro Ala 
                405                 410                 415     


Ser Cys Cys Asp Phe Arg Thr Cys Val Leu Lys Asp Gly Ala Lys Cys 
            420                 425                 430         


Tyr Lys Gly Leu Cys Cys Lys Asp Cys Gln Ile Leu Gln Ser Gly Val 
        435                 440                 445             


Glu Cys Arg Pro Lys Ala His Pro Glu Cys Asp Ile Ala Glu Asn Cys 
    450                 455                 460                 


Asn Gly Thr Ser Pro Glu Cys Gly Pro Asp Ile Thr Leu Ile Asn Gly 
465                 470                 475                 480 


Leu Ser Cys Lys Asn Asn Lys Phe Ile Cys Tyr Asp Gly Asp Cys His 
                485                 490                 495     


Asp Leu Asp Ala Arg Cys Glu Ser Val Phe Gly Lys Gly Ser Arg Asn 
            500                 505                 510         


Ala Pro Phe Ala Cys Tyr Glu Glu Ile Gln Ser Gln Ser Asp Arg Phe 
        515                 520                 525             


Gly Asn Cys Gly Arg Asp Arg Asn Asn Lys Tyr Val Phe Cys Gly Trp 
    530                 535                 540                 


Arg Asn Leu Ile Cys Gly Arg Leu Val Cys Thr Tyr Pro Thr Arg Lys 
545                 550                 555                 560 


Pro Phe His Gln Glu Asn Gly Asp Val Ile Tyr Ala Phe Val Arg Asp 
                565                 570                 575     


Ser Val Cys Ile Thr Val Asp Tyr Lys Leu Pro Arg Thr Val Pro Asp 
            580                 585                 590         


Pro Leu Ala Val Lys Asn Gly Ser Gln Cys Asp Ile Gly Arg Val Cys 
        595                 600                 605             


Val Asn Arg Glu Cys Val Glu Ser Arg Ile Ile Lys Ala Ser Ala His 
    610                 615                 620                 


Val Cys Ser Gln Gln Cys Ser Gly His Gly Val Cys Asp Ser Arg Asn 
625                 630                 635                 640 


Lys Cys His Cys Ser Pro Gly Tyr Lys Pro Pro Asn Cys Gln Ile Arg 
                645                 650                 655     


Ser Lys Gly Phe Ser Ile Phe Pro Glu Glu Asp Met Gly Ser Ile Met 
            660                 665                 670         


Glu Arg Ala Ser Gly Lys Thr Glu Asn Thr Trp Leu Leu Gly Phe Leu 
        675                 680                 685             


Ile Ala Leu Pro Ile Leu Ile Val Thr Thr Ala Ile Val Leu Ala Arg 
    690                 695                 700                 


Lys Gln Leu Lys Lys Trp Phe Ala Lys Glu Glu Glu Phe Pro Ser Ser 
705                 710                 715                 720 


Glu Ser Lys Ser Glu Gly Ser Thr Gln Thr Tyr Ala Ser Gln Ser Ser 
                725                 730                 735     


Ser Glu Gly Ser Thr Gln Thr Tyr Ala Ser Gln Thr Arg Ser Glu Ser 
            740                 745                 750         


Ser Ser Gln Ala Asp Thr Ser Lys Ser Lys Ser Glu Asp Ser Ala Glu 
        755                 760                 765             


Ala Tyr Thr Ser Arg Ser Lys Ser Gln Asp Ser Thr Gln Thr Gln Ser 
    770                 775                 780                 


Ser Ser Asn 
785         


<210>  286
<211>  629
<212>  PRT
<213>  Homo Sapiens

<400>  286

Met Phe Arg Leu Trp Leu Leu Leu Ala Gly Leu Cys Gly Leu Leu Ala 
1               5                   10                  15      


Ser Arg Pro Gly Phe Gln Asn Ser Leu Leu Gln Ile Val Ile Pro Glu 
            20                  25                  30          


Lys Ile Gln Thr Asn Thr Asn Asp Ser Ser Glu Ile Glu Tyr Glu Gln 
        35                  40                  45              


Ile Ser Tyr Ile Ile Pro Ile Asp Glu Lys Leu Tyr Thr Val His Leu 
    50                  55                  60                  


Lys Gln Arg Tyr Phe Leu Ala Asp Asn Phe Met Ile Tyr Leu Tyr Asn 
65                  70                  75                  80  


Gln Gly Ser Met Asn Thr Tyr Ser Ser Asp Ile Gln Thr Gln Cys Tyr 
                85                  90                  95      


Tyr Gln Gly Asn Ile Glu Gly Tyr Pro Asp Ser Met Val Thr Leu Ser 
            100                 105                 110         


Thr Cys Ser Gly Leu Arg Gly Ile Leu Gln Phe Glu Asn Val Ser Tyr 
        115                 120                 125             


Gly Ile Glu Pro Leu Glu Ser Ala Val Glu Phe Gln His Val Leu Tyr 
    130                 135                 140                 


Lys Leu Lys Asn Glu Asp Asn Asp Ile Ala Ile Phe Ile Asp Arg Ser 
145                 150                 155                 160 


Leu Lys Glu Gln Pro Met Asp Asp Asn Ile Phe Ile Ser Glu Lys Ser 
                165                 170                 175     


Glu Pro Ala Val Pro Asp Leu Phe Pro Leu Tyr Leu Glu Met His Ile 
            180                 185                 190         


Val Val Asp Lys Thr Leu Tyr Asp Tyr Trp Gly Ser Asp Ser Met Ile 
        195                 200                 205             


Val Thr Asn Lys Val Ile Glu Ile Val Gly Leu Ala Asn Ser Met Phe 
    210                 215                 220                 


Thr Gln Phe Lys Val Thr Ile Val Leu Ser Ser Leu Glu Leu Trp Ser 
225                 230                 235                 240 


Asp Glu Asn Lys Ile Ser Thr Val Gly Glu Ala Asp Glu Leu Leu Gln 
                245                 250                 255     


Lys Phe Leu Glu Trp Lys Gln Ser Tyr Leu Asn Leu Arg Pro His Asp 
            260                 265                 270         


Ile Ala Tyr Leu Leu Ile Tyr Met Asp Tyr Pro Arg Tyr Leu Gly Ala 
        275                 280                 285             


Val Phe Pro Gly Thr Met Cys Ile Thr Arg Tyr Ser Ala Gly Val Ala 
    290                 295                 300                 


Leu Gln Cys Gly Pro Ala Ser Cys Cys Asp Phe Arg Thr Cys Val Leu 
305                 310                 315                 320 


Lys Asp Gly Ala Lys Cys Tyr Lys Gly Leu Cys Cys Lys Asp Cys Gln 
                325                 330                 335     


Ile Leu Gln Ser Gly Val Glu Cys Arg Pro Lys Ala His Pro Glu Cys 
            340                 345                 350         


Asp Ile Ala Glu Asn Cys Asn Gly Thr Ser Pro Glu Cys Gly Pro Asp 
        355                 360                 365             


Ile Thr Leu Ile Asn Gly Leu Ser Cys Lys Asn Asn Lys Phe Ile Cys 
    370                 375                 380                 


Tyr Asp Gly Asp Cys His Asp Leu Asp Ala Arg Cys Glu Ser Val Phe 
385                 390                 395                 400 


Gly Lys Gly Ser Arg Asn Ala Pro Phe Ala Cys Tyr Glu Glu Ile Gln 
                405                 410                 415     


Ser Gln Ser Asp Arg Phe Gly Asn Cys Gly Arg Asp Arg Asn Asn Lys 
            420                 425                 430         


Tyr Val Phe Cys Gly Trp Arg Asn Leu Ile Cys Gly Arg Leu Val Cys 
        435                 440                 445             


Thr Tyr Pro Thr Arg Lys Pro Phe His Gln Glu Asn Gly Asp Val Ile 
    450                 455                 460                 


Tyr Ala Phe Val Arg Asp Ser Val Cys Ile Thr Val Asp Tyr Lys Leu 
465                 470                 475                 480 


Pro Arg Thr Val Pro Asp Pro Leu Ala Val Lys Asn Gly Ser Gln Cys 
                485                 490                 495     


Asp Ile Gly Arg Val Cys Val Asn Arg Glu Cys Val Glu Ser Arg Ile 
            500                 505                 510         


Ile Lys Ala Ser Ala His Val Cys Ser Gln Gln Cys Ser Gly His Gly 
        515                 520                 525             


Val Cys Asp Ser Arg Asn Lys Cys His Cys Ser Pro Gly Tyr Lys Pro 
    530                 535                 540                 


Pro Asn Cys Gln Ile Arg Ser Lys Gly Phe Ser Ile Phe Pro Glu Glu 
545                 550                 555                 560 


Asp Met Gly Ser Ile Met Glu Arg Ala Ser Gly Lys Thr Glu Asn Thr 
                565                 570                 575     


Trp Leu Leu Gly Phe Leu Ile Ala Leu Pro Ile Leu Ile Val Thr Thr 
            580                 585                 590         


Ala Ile Val Leu Ala Arg Lys Gln Leu Lys Lys Trp Phe Ala Lys Glu 
        595                 600                 605             


Glu Glu Phe Pro Ser Ser Glu Ser Lys Ser Gln Asp Ser Thr Gln Thr 
    610                 615                 620                 


Gln Ser Ser Ser Asn 
625                 


<210>  287
<211>  184
<212>  PRT
<213>  Homo Sapiens

<400>  287

Met Phe Arg Leu Trp Leu Leu Leu Ala Gly Leu Cys Gly Leu Leu Ala 
1               5                   10                  15      


Ser Arg Pro Gly Phe Gln Asn Ser Leu Leu Gln Ile Val Ile Pro Glu 
            20                  25                  30          


Lys Ile Gln Thr Asn Thr Asn Asp Ser Ser Glu Ile Glu Tyr Glu Gln 
        35                  40                  45              


Ile Ser Tyr Ile Ile Pro Ile Asp Glu Lys Leu Tyr Thr Val His Leu 
    50                  55                  60                  


Lys Gln Arg Tyr Phe Leu Ala Asp Asn Phe Met Ile Tyr Leu Tyr Asn 
65                  70                  75                  80  


Gln Gly Ser Met Asn Thr Tyr Ser Ser Asp Ile Gln Thr Gln Cys Tyr 
                85                  90                  95      


Tyr Gln Gly Asn Ile Glu Gly Tyr Pro Asp Ser Met Val Thr Leu Ser 
            100                 105                 110         


Thr Cys Ser Gly Leu Arg Gly Ile Leu Gln Phe Glu Asn Val Ser Tyr 
        115                 120                 125             


Gly Ile Glu Pro Leu Glu Ser Ala Val Glu Phe Gln His Val Leu Tyr 
    130                 135                 140                 


Lys Leu Lys Asn Glu Asp Asn Asp Ile Ala Ile Phe Ile Asp Arg Ser 
145                 150                 155                 160 


Leu Lys Glu Gln Pro Met Asp Asp Asn Ile Phe Ile Ser Glu Lys Tyr 
                165                 170                 175     


Asp Tyr Trp Gly Ser Asp Ser Met 
            180                 


<210>  288
<211>  155
<212>  PRT
<213>  Homo Sapiens

<400>  288

Met Phe Arg Leu Trp Leu Leu Leu Ala Gly Leu Cys Gly Leu Leu Ala 
1               5                   10                  15      


Ser Arg Pro Gly Phe Gln Asn Ser Leu Leu Gln Ile Val Ile Pro Glu 
            20                  25                  30          


Lys Ile Gln Thr Asn Thr Asn Asp Ser Ser Glu Ile Glu Tyr Glu Gln 
        35                  40                  45              


Ile Ser Tyr Ile Ile Pro Ile Asp Glu Lys Leu Tyr Thr Val His Leu 
    50                  55                  60                  


Lys Gln Arg Tyr Phe Leu Ala Asp Asn Phe Met Ile Tyr Leu Tyr Asn 
65                  70                  75                  80  


Gln Gly Ser Met Asn Thr Tyr Ser Ser Asp Ile Gln Thr Gln Cys Tyr 
                85                  90                  95      


Tyr Gln Gly Asn Ile Glu Gly Tyr Pro Asp Ser Met Val Thr Leu Ser 
            100                 105                 110         


Thr Cys Ser Gly Leu Arg Ser Leu Lys Glu Gln Pro Met Asp Asp Asn 
        115                 120                 125             


Ile Phe Ile Ser Glu Lys Ser Glu Pro Ala Val Pro Asp Leu Phe Pro 
    130                 135                 140                 


Leu Tyr Leu Glu Met His Ile Val Val Asp Lys 
145                 150                 155 


<210>  289
<211>  53
<212>  PRT
<213>  Homo Sapiens

<400>  289

Met Ile Tyr Leu Tyr Asn Gln Gly Ser Met Asn Thr Tyr Ser Ser Asp 
1               5                   10                  15      


Ile Gln Thr Gln Cys Tyr Tyr Gln Gly Asn Ile Glu Gly Tyr Pro Asp 
            20                  25                  30          


Ser Met Val Thr Leu Ser Thr Cys Ser Gly Leu Arg Gly Ile Leu Gln 
        35                  40                  45              


Phe Glu Asn Val Ser 
    50              


<210>  290
<211>  688
<212>  PRT
<213>  Homo Sapiens

<400>  290

Met Asn Val Arg Gly Ala Ala Pro Gly Val Arg Ala Ser Pro Arg Pro 
1               5                   10                  15      


Trp Gln Phe Pro Thr Ser Gln Arg Leu Pro Ala Gly Ser Pro Glu Ala 
            20                  25                  30          


Ala Pro Cys Ser Ala Ser Gly Cys Cys Trp Pro Gly Ser Ala Ala Ser 
        35                  40                  45              


Trp Arg Gln Asp Pro Glu Gln Ile Ser Tyr Ile Ile Pro Ile Asp Glu 
    50                  55                  60                  


Lys Leu Tyr Thr Val His Leu Lys Gln Arg Tyr Phe Leu Ala Asp Asn 
65                  70                  75                  80  


Phe Met Ile Tyr Leu Tyr Asn Gln Gly Ser Met Asn Thr Tyr Ser Ser 
                85                  90                  95      


Asp Ile Gln Thr Gln Cys Tyr Tyr Gln Gly Asn Ile Glu Gly Tyr Pro 
            100                 105                 110         


Asp Ser Met Val Thr Leu Ser Thr Cys Ser Gly Leu Arg Gly Ile Leu 
        115                 120                 125             


Gln Phe Glu Asn Val Ser Tyr Gly Ile Glu Pro Leu Glu Ser Ala Val 
    130                 135                 140                 


Glu Phe Gln His Val Leu Tyr Lys Leu Lys Asn Glu Asp Asn Asp Ile 
145                 150                 155                 160 


Ala Ile Phe Ile Asp Arg Ser Leu Lys Glu Gln Pro Met Asp Asp Asn 
                165                 170                 175     


Ile Phe Ile Ser Glu Lys Ser Glu Pro Ala Val Pro Asp Leu Phe Pro 
            180                 185                 190         


Leu Tyr Leu Glu Met His Ile Val Val Asp Lys Thr Leu Tyr Asp Tyr 
        195                 200                 205             


Trp Gly Ser Asp Ser Met Ile Val Thr Asn Lys Val Ile Glu Ile Val 
    210                 215                 220                 


Gly Leu Ala Asn Ser Met Phe Thr Gln Phe Lys Val Thr Ile Val Leu 
225                 230                 235                 240 


Ser Ser Leu Glu Leu Trp Ser Asp Glu Asn Lys Ile Ser Thr Val Gly 
                245                 250                 255     


Glu Ala Asp Glu Leu Leu Gln Lys Phe Leu Glu Trp Lys Gln Ser Tyr 
            260                 265                 270         


Leu Asn Leu Arg Pro His Asp Ile Ala Tyr Leu Leu Ile Tyr Met Asp 
        275                 280                 285             


Tyr Pro Arg Tyr Leu Gly Ala Val Phe Pro Gly Thr Met Cys Ile Thr 
    290                 295                 300                 


Arg Tyr Ser Ala Gly Val Ala Leu Gln Cys Gly Pro Ala Ser Cys Cys 
305                 310                 315                 320 


Asp Phe Arg Thr Cys Val Leu Lys Asp Gly Ala Lys Cys Tyr Lys Gly 
                325                 330                 335     


Leu Cys Cys Lys Asp Cys Gln Ile Leu Gln Ser Gly Val Glu Cys Arg 
            340                 345                 350         


Pro Lys Ala His Pro Glu Cys Asp Ile Ala Glu Asn Cys Asn Gly Thr 
        355                 360                 365             


Ser Pro Glu Cys Gly Pro Asp Ile Thr Leu Ile Asn Gly Leu Ser Cys 
    370                 375                 380                 


Lys Asn Asn Lys Phe Ile Cys Tyr Asp Gly Asp Cys His Asp Leu Asp 
385                 390                 395                 400 


Ala Arg Cys Glu Ser Val Phe Gly Lys Gly Ser Arg Asn Ala Pro Phe 
                405                 410                 415     


Ala Cys Tyr Glu Glu Ile Gln Ser Gln Ser Asp Arg Phe Gly Asn Cys 
            420                 425                 430         


Gly Arg Asp Arg Asn Asn Lys Tyr Val Phe Cys Gly Trp Arg Asn Leu 
        435                 440                 445             


Ile Cys Gly Arg Leu Val Cys Thr Tyr Pro Thr Arg Lys Pro Phe His 
    450                 455                 460                 


Gln Glu Asn Gly Asp Val Ile Tyr Ala Phe Val Arg Asp Ser Val Cys 
465                 470                 475                 480 


Ile Thr Val Asp Tyr Lys Leu Pro Arg Thr Val Pro Asp Pro Leu Ala 
                485                 490                 495     


Val Lys Asn Gly Ser Gln Cys Asp Ile Gly Arg Val Cys Val Asn Arg 
            500                 505                 510         


Glu Cys Val Glu Ser Arg Ile Ile Lys Ala Ser Ala His Val Cys Ser 
        515                 520                 525             


Gln Gln Cys Ser Gly His Gly Val Cys Asp Ser Arg Asn Lys Cys His 
    530                 535                 540                 


Cys Ser Pro Gly Tyr Lys Pro Pro Asn Cys Gln Ile Arg Ser Lys Gly 
545                 550                 555                 560 


Phe Ser Ile Phe Pro Glu Glu Asp Met Gly Ser Ile Met Glu Arg Ala 
                565                 570                 575     


Ser Gly Lys Thr Glu Asn Thr Trp Leu Leu Gly Phe Leu Ile Ala Leu 
            580                 585                 590         


Pro Ile Leu Ile Val Thr Thr Ala Ile Val Leu Ala Arg Lys Gln Leu 
        595                 600                 605             


Lys Lys Trp Phe Ala Lys Glu Glu Glu Phe Pro Ser Ser Glu Ser Lys 
    610                 615                 620                 


Ser Glu Gly Ser Thr Gln Thr Tyr Ala Ser Gln Ser Ser Ser Glu Gly 
625                 630                 635                 640 


Ser Thr Gln Thr Tyr Ala Ser Gln Thr Arg Ser Glu Ser Ser Ser Gln 
                645                 650                 655     


Ala Asp Thr Ser Lys Ser Lys Ser Glu Asp Ser Ala Glu Ala Tyr Thr 
            660                 665                 670         


Ser Arg Ser Lys Ser Gln Asp Ser Thr Gln Thr Gln Ser Ser Ser Asn 
        675                 680                 685             


<210>  291
<211>  173
<212>  PRT
<213>  Homo Sapiens

<400>  291

Met Gln Leu Ala Leu Phe Lys Asn Met Lys Ser Trp His Phe Ile Leu 
1               5                   10                  15      


Lys Ser Gly Ser Leu Phe Pro Ser Leu Glu Cys Ser His Ile Trp Leu 
            20                  25                  30          


Asn Ser Phe Glu Lys Ile Leu Glu Thr Gly Leu Ala Asn Met Asn Ile 
        35                  40                  45              


Tyr Leu Gly Phe Gln Asn Ser Leu Leu Gln Ile Val Ile Pro Glu Lys 
    50                  55                  60                  


Ile Gln Thr Asn Thr Asn Asp Ser Ser Glu Ile Glu Tyr Glu Gln Ile 
65                  70                  75                  80  


Ser Tyr Ile Ile Pro Ile Asp Glu Lys Leu Tyr Thr Val His Leu Lys 
                85                  90                  95      


Gln Arg Tyr Phe Leu Ala Asp Asn Phe Met Ile Tyr Leu Tyr Asn Gln 
            100                 105                 110         


Gly Ser Met Asn Thr Tyr Ser Ser Asp Ile Gln Thr Gln Cys Tyr Tyr 
        115                 120                 125             


Gln Gly Asn Ile Glu Gly Tyr Pro Asp Ser Met Val Thr Leu Ser Thr 
    130                 135                 140                 


Cys Ser Gly Leu Arg Gly Ile Leu Gln Phe Glu Asn Val Ser Tyr Gly 
145                 150                 155                 160 


Ile Glu Pro Leu Glu Ser Ala Val Glu Phe Gln His Val 
                165                 170             


<210>  292
<211>  787
<212>  PRT
<213>  Homo Sapiens

<400>  292

Met Gly Trp Arg Pro Arg Arg Ala Arg Gly Thr Pro Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Trp Pro Val Pro Gly Ala Gly Val Leu Gln 
            20                  25                  30          


Gly His Ile Pro Gly Gln Pro Val Thr Pro His Trp Val Leu Asp Gly 
        35                  40                  45              


Gln Pro Trp Arg Thr Val Ser Leu Glu Glu Pro Val Ser Lys Pro Asp 
    50                  55                  60                  


Met Gly Leu Val Ala Leu Glu Ala Glu Gly Gln Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Leu Glu Lys Asn His Arg Leu Leu Ala Pro Gly Tyr Ile Glu Thr His 
                85                  90                  95      


Tyr Gly Pro Asp Gly Gln Pro Val Val Leu Ala Pro Asn His Thr Asp 
            100                 105                 110         


His Cys His Tyr Gln Gly Arg Val Arg Gly Phe Pro Asp Ser Trp Val 
        115                 120                 125             


Val Leu Cys Thr Cys Ser Gly Met Ser Gly Leu Ile Thr Leu Ser Arg 
    130                 135                 140                 


Asn Ala Ser Tyr Tyr Leu Arg Pro Trp Pro Pro Arg Gly Ser Lys Asp 
145                 150                 155                 160 


Phe Ser Thr His Glu Ile Phe Arg Met Glu Gln Leu Leu Thr Trp Lys 
                165                 170                 175     


Gly Thr Cys Gly His Arg Asp Pro Gly Asn Lys Ala Gly Met Thr Ser 
            180                 185                 190         


Leu Pro Gly Gly Pro Gln Ser Arg Gly Arg Arg Glu Ala Arg Arg Thr 
        195                 200                 205             


Arg Lys Tyr Leu Glu Leu Tyr Ile Val Ala Asp His Thr Leu Phe Leu 
    210                 215                 220                 


Thr Arg His Arg Asn Leu Asn His Thr Lys Gln Arg Leu Leu Glu Val 
225                 230                 235                 240 


Ala Asn Tyr Val Asp Gln Leu Leu Arg Thr Leu Asp Ile Gln Val Ala 
                245                 250                 255     


Leu Thr Gly Leu Glu Val Trp Thr Glu Arg Asp Arg Ser Arg Val Thr 
            260                 265                 270         


Gln Asp Ala Asn Ala Thr Leu Trp Ala Phe Leu Gln Trp Arg Arg Gly 
        275                 280                 285             


Leu Trp Ala Gln Arg Pro His Asp Ser Ala Gln Leu Leu Thr Gly Arg 
    290                 295                 300                 


Ala Phe Gln Gly Ala Thr Val Gly Leu Ala Pro Val Glu Gly Met Cys 
305                 310                 315                 320 


Arg Ala Glu Ser Ser Gly Gly Val Ser Thr Asp His Ser Glu Leu Pro 
                325                 330                 335     


Ile Gly Ala Ala Ala Thr Met Ala His Glu Ile Gly His Ser Leu Gly 
            340                 345                 350         


Leu Ser His Asp Pro Asp Gly Cys Cys Val Glu Ala Ala Ala Glu Ser 
        355                 360                 365             


Gly Gly Cys Val Met Ala Ala Ala Thr Gly His Pro Phe Pro Arg Val 
    370                 375                 380                 


Phe Ser Ala Cys Ser Arg Arg Gln Leu Arg Ala Phe Phe Arg Lys Gly 
385                 390                 395                 400 


Gly Gly Ala Cys Leu Ser Asn Ala Pro Asp Pro Gly Leu Pro Val Pro 
                405                 410                 415     


Pro Ala Leu Cys Gly Asn Gly Phe Val Glu Ala Gly Glu Glu Cys Asp 
            420                 425                 430         


Cys Gly Pro Gly Gln Glu Cys Arg Asp Leu Cys Cys Phe Ala His Asn 
        435                 440                 445             


Cys Ser Leu Arg Pro Gly Ala Gln Cys Ala His Gly Asp Cys Cys Val 
    450                 455                 460                 


Arg Cys Leu Leu Lys Pro Ala Gly Ala Leu Cys Arg Gln Ala Met Gly 
465                 470                 475                 480 


Asp Cys Asp Leu Pro Glu Phe Cys Thr Gly Thr Ser Ser His Cys Pro 
                485                 490                 495     


Pro Asp Val Tyr Leu Leu Asp Gly Ser Pro Cys Ala Arg Gly Ser Gly 
            500                 505                 510         


Tyr Cys Trp Asp Gly Ala Cys Pro Thr Leu Glu Gln Gln Cys Gln Gln 
        515                 520                 525             


Leu Trp Gly Pro Gly Ser His Pro Ala Pro Glu Ala Cys Phe Gln Val 
    530                 535                 540                 


Val Asn Ser Ala Gly Asp Ala His Gly Asn Cys Gly Gln Asp Ser Glu 
545                 550                 555                 560 


Gly His Phe Leu Pro Cys Ala Gly Arg Asp Ala Leu Cys Gly Lys Leu 
                565                 570                 575     


Gln Cys Gln Gly Gly Lys Pro Ser Leu Leu Ala Pro His Met Val Pro 
            580                 585                 590         


Val Asp Ser Thr Val His Leu Asp Gly Gln Glu Val Thr Cys Arg Gly 
        595                 600                 605             


Ala Leu Ala Leu Pro Ser Ala Gln Leu Asp Leu Leu Gly Leu Gly Leu 
    610                 615                 620                 


Val Glu Pro Gly Thr Gln Cys Gly Pro Arg Met Val Cys Asn Ser Asn 
625                 630                 635                 640 


His Asn Cys His Cys Ala Pro Gly Trp Ala Pro Pro Phe Cys Asp Lys 
                645                 650                 655     


Pro Gly Phe Gly Gly Ser Met Asp Ser Gly Pro Val Gln Ala Glu Asn 
            660                 665                 670         


His Asp Thr Phe Leu Leu Ala Met Leu Leu Ser Val Leu Leu Pro Leu 
        675                 680                 685             


Leu Pro Gly Ala Gly Leu Ala Trp Cys Cys Tyr Arg Leu Pro Gly Ala 
    690                 695                 700                 


His Leu Gln Arg Cys Ser Trp Gly Cys Arg Arg Asp Pro Ala Cys Ser 
705                 710                 715                 720 


Gly Pro Lys Asp Gly Pro His Arg Asp His Pro Leu Gly Gly Val His 
                725                 730                 735     


Pro Met Glu Leu Gly Pro Thr Ala Thr Gly Gln Pro Trp Pro Leu Asp 
            740                 745                 750         


Pro Glu Asn Ser His Glu Pro Ser Ser His Pro Glu Lys Pro Leu Pro 
        755                 760                 765             


Ala Val Ser Pro Asp Pro Gln Ala Asp Gln Val Gln Met Pro Arg Ser 
    770                 775                 780                 


Cys Leu Trp 
785         


<210>  293
<211>  813
<212>  PRT
<213>  Homo Sapiens

<400>  293

Met Gly Trp Arg Pro Arg Arg Ala Arg Gly Thr Pro Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Trp Pro Val Pro Gly Ala Gly Val Leu Gln 
            20                  25                  30          


Gly His Ile Pro Gly Gln Pro Val Thr Pro His Trp Val Leu Asp Gly 
        35                  40                  45              


Gln Pro Trp Arg Thr Val Ser Leu Glu Glu Pro Val Ser Lys Pro Asp 
    50                  55                  60                  


Met Gly Leu Val Ala Leu Glu Ala Glu Gly Gln Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Leu Glu Lys Asn His Arg Leu Leu Ala Pro Gly Tyr Ile Glu Thr His 
                85                  90                  95      


Tyr Gly Pro Asp Gly Gln Pro Val Val Leu Ala Pro Asn His Thr Asp 
            100                 105                 110         


His Cys His Tyr Gln Gly Arg Val Arg Gly Phe Pro Asp Ser Trp Val 
        115                 120                 125             


Val Leu Cys Thr Cys Ser Gly Met Ser Gly Leu Ile Thr Leu Ser Arg 
    130                 135                 140                 


Asn Ala Ser Tyr Tyr Leu Arg Pro Trp Pro Pro Arg Gly Ser Lys Asp 
145                 150                 155                 160 


Phe Ser Thr His Glu Ile Phe Arg Met Glu Gln Leu Leu Thr Trp Lys 
                165                 170                 175     


Gly Thr Cys Gly His Arg Asp Pro Gly Asn Lys Ala Gly Met Thr Ser 
            180                 185                 190         


Leu Pro Gly Gly Pro Gln Ser Arg Gly Arg Arg Glu Ala Arg Arg Thr 
        195                 200                 205             


Arg Lys Tyr Leu Glu Leu Tyr Ile Val Ala Asp His Thr Leu Phe Leu 
    210                 215                 220                 


Thr Arg His Arg Asn Leu Asn His Thr Lys Gln Arg Leu Leu Glu Val 
225                 230                 235                 240 


Ala Asn Tyr Val Asp Gln Leu Leu Arg Thr Leu Asp Ile Gln Val Ala 
                245                 250                 255     


Leu Thr Gly Leu Glu Val Trp Thr Glu Arg Asp Arg Ser Arg Val Thr 
            260                 265                 270         


Gln Asp Ala Asn Ala Thr Leu Trp Ala Phe Leu Gln Trp Arg Arg Gly 
        275                 280                 285             


Leu Trp Ala Gln Arg Pro His Asp Ser Ala Gln Leu Leu Thr Gly Arg 
    290                 295                 300                 


Ala Phe Gln Gly Ala Thr Val Gly Leu Ala Pro Val Glu Gly Met Cys 
305                 310                 315                 320 


Arg Ala Glu Ser Ser Gly Gly Val Ser Thr Asp His Ser Glu Leu Pro 
                325                 330                 335     


Ile Gly Ala Ala Ala Thr Met Ala His Glu Ile Gly His Ser Leu Gly 
            340                 345                 350         


Leu Ser His Asp Pro Asp Gly Cys Cys Val Glu Ala Ala Ala Glu Ser 
        355                 360                 365             


Gly Gly Cys Val Met Ala Ala Ala Thr Gly His Pro Phe Pro Arg Val 
    370                 375                 380                 


Phe Ser Ala Cys Ser Arg Arg Gln Leu Arg Ala Phe Phe Arg Lys Gly 
385                 390                 395                 400 


Gly Gly Ala Cys Leu Ser Asn Ala Pro Asp Pro Gly Leu Pro Val Pro 
                405                 410                 415     


Pro Ala Leu Cys Gly Asn Gly Phe Val Glu Ala Gly Glu Glu Cys Asp 
            420                 425                 430         


Cys Gly Pro Gly Gln Glu Cys Arg Asp Leu Cys Cys Phe Ala His Asn 
        435                 440                 445             


Cys Ser Leu Arg Pro Gly Ala Gln Cys Ala His Gly Asp Cys Cys Val 
    450                 455                 460                 


Arg Cys Leu Leu Lys Pro Ala Gly Ala Leu Cys Arg Gln Ala Met Gly 
465                 470                 475                 480 


Asp Cys Asp Leu Pro Glu Phe Cys Thr Gly Thr Ser Ser His Cys Pro 
                485                 490                 495     


Pro Asp Val Tyr Leu Leu Asp Gly Ser Pro Cys Ala Arg Gly Ser Gly 
            500                 505                 510         


Tyr Cys Trp Asp Gly Ala Cys Pro Thr Leu Glu Gln Gln Cys Gln Gln 
        515                 520                 525             


Leu Trp Gly Pro Gly Ser His Pro Ala Pro Glu Ala Cys Phe Gln Val 
    530                 535                 540                 


Val Asn Ser Ala Gly Asp Ala His Gly Asn Cys Gly Gln Asp Ser Glu 
545                 550                 555                 560 


Gly His Phe Leu Pro Cys Ala Gly Arg Asp Ala Leu Cys Gly Lys Leu 
                565                 570                 575     


Gln Cys Gln Gly Gly Lys Pro Ser Leu Leu Ala Pro His Met Val Pro 
            580                 585                 590         


Val Asp Ser Thr Val His Leu Asp Gly Gln Glu Val Thr Cys Arg Gly 
        595                 600                 605             


Ala Leu Ala Leu Pro Ser Ala Gln Leu Asp Leu Leu Gly Leu Gly Leu 
    610                 615                 620                 


Val Glu Pro Gly Thr Gln Cys Gly Pro Arg Met Val Cys Gln Ser Arg 
625                 630                 635                 640 


Arg Cys Arg Lys Asn Ala Phe Gln Glu Leu Gln Arg Cys Leu Thr Ala 
                645                 650                 655     


Cys His Ser His Gly Val Cys Asn Ser Asn His Asn Cys His Cys Ala 
            660                 665                 670         


Pro Gly Trp Ala Pro Pro Phe Cys Asp Lys Pro Gly Phe Gly Gly Ser 
        675                 680                 685             


Met Asp Ser Gly Pro Val Gln Ala Glu Asn His Asp Thr Phe Leu Leu 
    690                 695                 700                 


Ala Met Leu Leu Ser Val Leu Leu Pro Leu Leu Pro Gly Ala Gly Leu 
705                 710                 715                 720 


Ala Trp Cys Cys Tyr Arg Leu Pro Gly Ala His Leu Gln Arg Cys Ser 
                725                 730                 735     


Trp Gly Cys Arg Arg Asp Pro Ala Cys Ser Gly Pro Lys Asp Gly Pro 
            740                 745                 750         


His Arg Asp His Pro Leu Gly Gly Val His Pro Met Glu Leu Gly Pro 
        755                 760                 765             


Thr Ala Thr Gly Gln Pro Trp Pro Leu Asp Pro Glu Asn Ser His Glu 
    770                 775                 780                 


Pro Ser Ser His Pro Glu Lys Pro Leu Pro Ala Val Ser Pro Asp Pro 
785                 790                 795                 800 


Gln Ala Asp Gln Val Gln Met Pro Arg Ser Cys Leu Trp 
                805                 810             


<210>  294
<211>  812
<212>  PRT
<213>  Homo Sapiens

<400>  294

Met Gly Trp Arg Pro Arg Arg Ala Arg Gly Thr Pro Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Trp Pro Val Pro Gly Ala Gly Val Leu Gln 
            20                  25                  30          


Gly His Ile Pro Gly Gln Pro Val Thr Pro His Trp Val Leu Asp Gly 
        35                  40                  45              


Gln Pro Trp Arg Thr Val Ser Leu Glu Glu Pro Val Ser Lys Pro Asp 
    50                  55                  60                  


Met Gly Leu Val Ala Leu Glu Ala Glu Gly Gln Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Leu Glu Lys Asn His Arg Leu Leu Ala Pro Gly Tyr Ile Glu Thr His 
                85                  90                  95      


Tyr Gly Pro Asp Gly Gln Pro Val Val Leu Ala Pro Asn His Thr Asp 
            100                 105                 110         


His Cys His Tyr Gln Gly Arg Val Arg Gly Phe Pro Asp Ser Trp Val 
        115                 120                 125             


Val Leu Cys Thr Cys Ser Gly Met Ser Gly Leu Ile Thr Leu Ser Arg 
    130                 135                 140                 


Asn Ala Ser Tyr Tyr Leu Arg Pro Trp Pro Pro Arg Gly Ser Lys Asp 
145                 150                 155                 160 


Phe Ser Thr His Glu Ile Phe Arg Met Glu Gln Leu Leu Thr Trp Lys 
                165                 170                 175     


Gly Thr Cys Gly His Arg Asp Pro Gly Asn Lys Ala Gly Met Thr Ser 
            180                 185                 190         


Leu Pro Gly Gly Pro Gln Ser Arg Gly Arg Arg Glu Ala Arg Arg Thr 
        195                 200                 205             


Arg Lys Tyr Leu Glu Leu Tyr Ile Val Ala Asp His Thr Leu Phe Leu 
    210                 215                 220                 


Thr Arg His Arg Asn Leu Asn His Thr Lys Gln Arg Leu Leu Glu Val 
225                 230                 235                 240 


Ala Asn Tyr Val Asp Gln Leu Leu Arg Thr Leu Asp Ile Gln Val Ala 
                245                 250                 255     


Leu Thr Gly Leu Glu Val Trp Thr Glu Arg Asp Arg Ser Arg Val Thr 
            260                 265                 270         


Gln Asp Ala Asn Ala Thr Leu Trp Ala Phe Leu Gln Trp Arg Arg Gly 
        275                 280                 285             


Leu Trp Ala Gln Arg Pro His Asp Ser Ala Gln Leu Leu Thr Gly Arg 
    290                 295                 300                 


Ala Phe Gln Gly Ala Thr Val Gly Leu Ala Pro Val Glu Gly Met Cys 
305                 310                 315                 320 


Arg Ala Glu Ser Ser Gly Gly Val Ser Thr Asp His Ser Glu Leu Pro 
                325                 330                 335     


Ile Gly Ala Ala Ala Thr Met Ala His Glu Ile Gly His Ser Leu Gly 
            340                 345                 350         


Leu Ser His Asp Pro Asp Gly Cys Cys Val Glu Ala Ala Ala Glu Ser 
        355                 360                 365             


Gly Gly Cys Val Met Ala Ala Ala Thr Gly His Pro Phe Pro Arg Val 
    370                 375                 380                 


Phe Ser Ala Cys Ser Arg Arg Gln Leu Arg Ala Phe Phe Arg Lys Gly 
385                 390                 395                 400 


Gly Gly Ala Cys Leu Ser Asn Ala Pro Asp Pro Gly Leu Pro Val Pro 
                405                 410                 415     


Pro Ala Leu Cys Gly Asn Gly Phe Val Glu Ala Gly Glu Glu Cys Asp 
            420                 425                 430         


Cys Gly Pro Gly Gln Glu Cys Arg Asp Leu Cys Cys Phe Ala His Asn 
        435                 440                 445             


Cys Ser Leu Arg Pro Gly Ala Gln Cys Ala His Gly Asp Cys Cys Val 
    450                 455                 460                 


Arg Cys Leu Leu Lys Pro Ala Gly Ala Leu Cys Arg Gln Ala Met Gly 
465                 470                 475                 480 


Asp Cys Asp Leu Pro Glu Phe Cys Thr Gly Thr Ser Ser His Cys Pro 
                485                 490                 495     


Pro Asp Val Tyr Leu Leu Asp Gly Ser Pro Cys Ala Arg Gly Ser Gly 
            500                 505                 510         


Tyr Cys Trp Asp Gly Ala Cys Pro Thr Leu Glu Gln Gln Cys Gln Gln 
        515                 520                 525             


Leu Trp Gly Pro Gly Ser His Pro Ala Pro Glu Ala Cys Phe Gln Val 
    530                 535                 540                 


Val Asn Ser Ala Gly Asp Ala His Gly Asn Cys Gly Gln Asp Ser Glu 
545                 550                 555                 560 


Gly His Phe Leu Pro Cys Ala Gly Arg Asp Ala Leu Cys Gly Lys Leu 
                565                 570                 575     


Gln Cys Gln Gly Gly Lys Pro Ser Leu Leu Ala Pro His Met Val Pro 
            580                 585                 590         


Val Asp Ser Thr Val His Leu Asp Gly Gln Glu Val Thr Cys Arg Gly 
        595                 600                 605             


Ala Leu Ala Leu Pro Ser Ala Gln Leu Asp Leu Leu Gly Leu Gly Leu 
    610                 615                 620                 


Val Glu Pro Gly Thr Gln Cys Gly Pro Arg Met Val Cys Gln Ser Arg 
625                 630                 635                 640 


Arg Cys Arg Lys Asn Ala Phe Gln Glu Leu Gln Arg Cys Leu Thr Ala 
                645                 650                 655     


Cys His Ser His Gly Val Cys Asn Ser Asn His Asn Cys His Cys Ala 
            660                 665                 670         


Pro Gly Trp Ala Pro Pro Phe Cys Asp Lys Pro Gly Phe Gly Gly Ser 
        675                 680                 685             


Met Asp Ser Gly Pro Val Gln Ala Glu Asn His Asp Thr Phe Leu Leu 
    690                 695                 700                 


Ala Met Leu Leu Ser Val Leu Leu Pro Leu Leu Pro Gly Ala Gly Leu 
705                 710                 715                 720 


Ala Trp Cys Cys Tyr Arg Leu Pro Gly Ala His Leu Gln Arg Cys Ser 
                725                 730                 735     


Trp Gly Cys Arg Arg Asp Pro Ala Cys Ser Gly Pro Lys Asp Gly Pro 
            740                 745                 750         


His Arg Asp His Pro Leu Gly Gly Val His Pro Met Glu Leu Gly Pro 
        755                 760                 765             


Thr Ala Thr Gly Gln Pro Trp Pro Leu Asp Pro Glu Asn Ser His Glu 
    770                 775                 780                 


Pro Ser Ser His Pro Glu Lys Pro Leu Pro Ala Val Ser Pro Asp Pro 
785                 790                 795                 800 


Gln Asp Gln Val Gln Met Pro Arg Ser Cys Leu Trp 
                805                 810         


<210>  295
<211>  692
<212>  PRT
<213>  Homo Sapiens

<400>  295

Met Gly Trp Arg Pro Arg Arg Ala Arg Gly Thr Pro Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Trp Pro Val Pro Gly Ala Gly Val Leu Gln 
            20                  25                  30          


Gly His Ile Pro Gly Gln Pro Val Thr Pro His Trp Val Leu Asp Gly 
        35                  40                  45              


Gln Pro Trp Arg Thr Val Ser Leu Glu Glu Pro Val Ser Lys Pro Asp 
    50                  55                  60                  


Met Gly Leu Val Ala Leu Glu Ala Glu Gly Gln Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Leu Glu Lys Asn His Arg Leu Leu Ala Pro Gly Tyr Ile Glu Thr His 
                85                  90                  95      


Tyr Gly Pro Asp Gly Gln Pro Val Val Leu Ala Pro Asn His Thr Asp 
            100                 105                 110         


His Cys His Tyr Gln Gly Arg Val Arg Gly Phe Pro Asp Ser Trp Val 
        115                 120                 125             


Val Leu Cys Thr Cys Ser Gly Met Ser Gly Leu Ile Thr Leu Ser Arg 
    130                 135                 140                 


Asn Ala Ser Tyr Tyr Leu Arg Pro Trp Pro Pro Arg Gly Ser Lys Asp 
145                 150                 155                 160 


Phe Ser Thr His Glu Ile Phe Arg Met Glu Gln Leu Leu Thr Trp Lys 
                165                 170                 175     


Gly Thr Cys Gly His Arg Asp Pro Gly Asn Lys Ala Gly Met Thr Ser 
            180                 185                 190         


Leu Pro Gly Gly Pro Gln Ser Arg Gly Arg Arg Glu Ala Arg Arg Thr 
        195                 200                 205             


Arg Lys Tyr Leu Glu Leu Tyr Ile Val Ala Asp His Thr Leu Phe Leu 
    210                 215                 220                 


Thr Arg His Arg Asn Leu Asn His Thr Lys Gln Arg Leu Leu Glu Val 
225                 230                 235                 240 


Ala Asn Tyr Val Asp Gln Leu Leu Arg Thr Leu Asp Ile Gln Val Ala 
                245                 250                 255     


Leu Thr Gly Leu Glu Val Trp Thr Glu Arg Asp Arg Ser Arg Arg Gln 
            260                 265                 270         


Leu Arg Ala Phe Phe Arg Lys Gly Gly Gly Ala Cys Leu Ser Asn Ala 
        275                 280                 285             


Pro Asp Pro Gly Leu Pro Val Pro Pro Ala Leu Cys Gly Asn Gly Phe 
    290                 295                 300                 


Val Glu Ala Gly Glu Glu Cys Asp Cys Gly Pro Gly Gln Glu Cys Arg 
305                 310                 315                 320 


Asp Leu Cys Cys Phe Ala His Asn Cys Ser Leu Arg Pro Gly Ala Gln 
                325                 330                 335     


Cys Ala His Gly Asp Cys Cys Val Arg Cys Leu Leu Lys Pro Ala Gly 
            340                 345                 350         


Ala Leu Cys Arg Gln Ala Met Gly Asp Cys Asp Leu Pro Glu Phe Cys 
        355                 360                 365             


Thr Gly Thr Ser Ser His Cys Pro Pro Asp Val Tyr Leu Leu Asp Gly 
    370                 375                 380                 


Ser Pro Cys Ala Arg Gly Ser Gly Tyr Cys Trp Asp Gly Ala Cys Pro 
385                 390                 395                 400 


Thr Leu Glu Gln Gln Cys Gln Gln Leu Trp Gly Pro Gly Ser His Pro 
                405                 410                 415     


Ala Pro Glu Ala Cys Phe Gln Val Val Asn Ser Ala Gly Asp Ala His 
            420                 425                 430         


Gly Asn Cys Gly Gln Asp Ser Glu Gly His Phe Leu Pro Cys Ala Gly 
        435                 440                 445             


Arg Asp Ala Leu Cys Gly Lys Leu Gln Cys Gln Gly Gly Lys Pro Ser 
    450                 455                 460                 


Leu Leu Ala Pro His Met Val Pro Val Asp Ser Thr Val His Leu Asp 
465                 470                 475                 480 


Gly Gln Glu Val Thr Cys Arg Gly Ala Leu Ala Leu Pro Ser Ala Gln 
                485                 490                 495     


Leu Asp Leu Leu Gly Leu Gly Leu Val Glu Pro Gly Thr Gln Cys Gly 
            500                 505                 510         


Pro Arg Met Val Cys Gln Ser Arg Arg Cys Arg Lys Asn Ala Phe Gln 
        515                 520                 525             


Glu Leu Gln Arg Cys Leu Thr Ala Cys His Ser His Gly Val Cys Asn 
    530                 535                 540                 


Ser Asn His Asn Cys His Cys Ala Pro Gly Trp Ala Pro Pro Phe Cys 
545                 550                 555                 560 


Asp Lys Pro Gly Phe Gly Gly Ser Met Asp Ser Gly Pro Val Gln Ala 
                565                 570                 575     


Glu Asn His Asp Thr Phe Leu Leu Ala Met Leu Leu Ser Val Leu Leu 
            580                 585                 590         


Pro Leu Leu Pro Gly Ala Gly Leu Ala Trp Cys Cys Tyr Arg Leu Pro 
        595                 600                 605             


Gly Ala His Leu Gln Arg Cys Ser Trp Gly Cys Arg Arg Asp Pro Ala 
    610                 615                 620                 


Cys Ser Gly Pro Lys Asp Gly Pro His Arg Asp His Pro Leu Gly Gly 
625                 630                 635                 640 


Val His Pro Met Glu Leu Gly Pro Thr Ala Thr Gly Gln Pro Trp Pro 
                645                 650                 655     


Leu Asp Pro Glu Asn Ser His Glu Pro Ser Ser His Pro Glu Lys Pro 
            660                 665                 670         


Leu Pro Ala Val Ser Pro Asp Pro Gln Asp Gln Val Gln Met Pro Arg 
        675                 680                 685             


Ser Cys Leu Trp 
    690         


<210>  296
<211>  138
<212>  PRT
<213>  Homo Sapiens

<400>  296

Met Gly Trp Arg Pro Arg Arg Ala Arg Gly Thr Pro Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Trp Pro Val Pro Gly Ala Gly Val Leu Gln 
            20                  25                  30          


Gly His Ile Pro Gly Gln Pro Val Thr Pro His Trp Val Leu Asp Gly 
        35                  40                  45              


Gln Pro Trp Arg Thr Val Ser Leu Glu Glu Pro Val Ser Lys Pro Asp 
    50                  55                  60                  


Met Gly Leu Val Ala Leu Glu Ala Glu Gly Gln Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Leu Glu Lys Asn His Arg Leu Leu Ala Pro Gly Tyr Ile Glu Thr His 
                85                  90                  95      


Tyr Gly Pro Asp Gly Gln Pro Val Val Leu Ala Pro Asn His Thr Val 
            100                 105                 110         


Arg Cys Phe His Gly Leu Trp Asp Ala Pro Pro Glu Val Pro Pro His 
        115                 120                 125             


His Ser Tyr Pro Tyr Ser Ser Leu His Ser 
    130                 135             


<210>  297
<211>  754
<212>  PRT
<213>  Homo Sapiens

<400>  297

Met Leu Pro Gly Cys Ile Phe Leu Met Ile Leu Leu Ile Pro Gln Val 
1               5                   10                  15      


Lys Glu Lys Phe Ile Leu Gly Val Glu Gly Gln Gln Leu Val Arg Pro 
            20                  25                  30          


Lys Lys Leu Pro Leu Ile Gln Lys Arg Asp Thr Gly His Thr His Asp 
        35                  40                  45              


Asp Asp Ile Leu Lys Thr Tyr Glu Glu Glu Leu Leu Tyr Glu Ile Lys 
    50                  55                  60                  


Leu Asn Arg Lys Thr Leu Val Leu His Leu Leu Arg Ser Arg Glu Phe 
65                  70                  75                  80  


Leu Gly Ser Asn Tyr Ser Glu Thr Phe Tyr Ser Met Lys Gly Glu Ala 
                85                  90                  95      


Phe Thr Arg His Pro Gln Ile Met Asp His Cys Phe Tyr Gln Gly Ser 
            100                 105                 110         


Ile Val His Glu Tyr Asp Ser Ala Ala Ser Ile Ser Thr Cys Asn Gly 
        115                 120                 125             


Leu Arg Gly Phe Phe Arg Ile Asn Asp Gln Arg Tyr Leu Ile Glu Pro 
    130                 135                 140                 


Val Lys Tyr Ser Asp Glu Gly Glu His Leu Val Phe Lys Tyr Asn Leu 
145                 150                 155                 160 


Arg Val Pro Tyr Gly Ala Asn Tyr Ser Cys Thr Glu Leu Asn Phe Thr 
                165                 170                 175     


Arg Lys Thr Val Pro Gly Asp Asn Glu Ser Glu Glu Asp Ser Lys Ile 
            180                 185                 190         


Lys Gly Ile His Asp Glu Lys Tyr Val Glu Leu Phe Ile Val Ala Asp 
        195                 200                 205             


Asp Thr Val Tyr Arg Arg Asn Gly His Pro His Asn Lys Leu Arg Asn 
    210                 215                 220                 


Arg Ile Trp Gly Met Val Asn Phe Val Asn Met Ile Tyr Lys Thr Leu 
225                 230                 235                 240 


Asn Ile His Val Thr Leu Val Gly Ile Glu Ile Trp Thr His Glu Asp 
                245                 250                 255     


Lys Ile Glu Leu Tyr Ser Asn Ile Glu Thr Thr Leu Leu Arg Phe Ser 
            260                 265                 270         


Phe Trp Gln Glu Lys Ile Leu Lys Thr Arg Lys Asp Phe Asp His Val 
        275                 280                 285             


Val Leu Leu Ser Gly Lys Trp Leu Tyr Ser His Val Gln Gly Ile Ser 
    290                 295                 300                 


Tyr Pro Gly Gly Met Cys Leu Pro Tyr Tyr Ser Thr Ser Ile Ile Lys 
305                 310                 315                 320 


Asp Leu Leu Pro Asp Thr Asn Ile Ile Ala Asn Arg Met Ala His Gln 
                325                 330                 335     


Leu Gly His Asn Leu Gly Met Gln His Asp Glu Phe Pro Cys Thr Cys 
            340                 345                 350         


Pro Ser Gly Lys Cys Val Met Asp Ser Asp Gly Ser Ile Pro Ala Leu 
        355                 360                 365             


Lys Phe Ser Lys Cys Ser Gln Asn Gln Tyr His Gln Tyr Leu Lys Asp 
    370                 375                 380                 


Tyr Lys Pro Thr Cys Met Leu Asn Ile Pro Phe Pro Tyr Asn Phe His 
385                 390                 395                 400 


Asp Phe Gln Phe Cys Gly Asn Lys Lys Leu Asp Glu Gly Glu Glu Cys 
                405                 410                 415     


Asp Cys Gly Pro Ala Gln Glu Cys Thr Asn Pro Cys Cys Asp Ala His 
            420                 425                 430         


Thr Cys Val Leu Lys Pro Gly Phe Thr Cys Ala Glu Gly Glu Cys Cys 
        435                 440                 445             


Glu Ser Cys Gln Ile Lys Lys Ala Gly Ser Ile Cys Arg Pro Ala Lys 
    450                 455                 460                 


Asp Glu Cys Asp Phe Pro Glu Met Cys Thr Gly His Ser Pro Ala Cys 
465                 470                 475                 480 


Pro Lys Asp Gln Phe Arg Val Asn Gly Phe Pro Cys Lys Asn Ser Glu 
                485                 490                 495     


Gly Tyr Cys Phe Met Gly Lys Cys Pro Thr Arg Glu Asp Gln Cys Ser 
            500                 505                 510         


Glu Leu Phe Asp Asp Glu Ala Ile Glu Ser His Asp Ile Cys Tyr Lys 
        515                 520                 525             


Met Asn Thr Lys Gly Asn Lys Phe Gly Tyr Cys Lys Asn Lys Glu Asn 
    530                 535                 540                 


Arg Phe Leu Pro Cys Glu Glu Lys Asp Val Arg Cys Gly Lys Ile Tyr 
545                 550                 555                 560 


Cys Thr Gly Gly Glu Leu Ser Ser Leu Leu Gly Glu Asp Lys Thr Tyr 
                565                 570                 575     


His Leu Lys Asp Pro Gln Lys Asn Ala Thr Val Lys Cys Lys Thr Ile 
            580                 585                 590         


Phe Leu Tyr His Asp Ser Thr Asp Ile Gly Leu Val Ala Ser Gly Thr 
        595                 600                 605             


Lys Cys Gly Glu Gly Met Val Cys Asn Asn Gly Glu Cys Leu Asn Met 
    610                 615                 620                 


Glu Lys Val Tyr Ile Ser Thr Asn Cys Pro Ser Gln Cys Asn Glu Asn 
625                 630                 635                 640 


Pro Val Asp Gly His Gly Leu Gln Cys His Cys Glu Glu Gly Gln Ala 
                645                 650                 655     


Pro Val Ala Cys Glu Glu Thr Leu His Val Thr Asn Ile Thr Ile Leu 
            660                 665                 670         


Val Val Val Leu Val Leu Val Ile Val Gly Ile Gly Val Leu Ile Leu 
        675                 680                 685             


Leu Val Arg Tyr Arg Lys Cys Ile Lys Leu Lys Gln Val Gln Ser Pro 
    690                 695                 700                 


Pro Thr Glu Thr Leu Gly Val Glu Asn Lys Gly Tyr Phe Gly Asp Glu 
705                 710                 715                 720 


Gln Gln Ile Arg Thr Glu Pro Ile Leu Pro Glu Ile His Phe Leu Asn 
                725                 730                 735     


Lys Pro Ala Ser Lys Asp Ser Arg Gly Ile Ala Asp Pro Asn Gln Ser 
            740                 745                 750         


Ala Lys 
        


<210>  298
<211>  776
<212>  PRT
<213>  Homo Sapiens

<400>  298

Met Leu Pro Gly Cys Ile Phe Leu Met Ile Leu Leu Ile Pro Gln Val 
1               5                   10                  15      


Lys Glu Lys Phe Ile Leu Gly Val Glu Gly Gln Gln Leu Val Arg Pro 
            20                  25                  30          


Lys Lys Leu Pro Leu Ile Gln Lys Arg Asp Thr Gly His Thr His Asp 
        35                  40                  45              


Asp Asp Ile Leu Lys Thr Tyr Glu Glu Glu Leu Leu Tyr Glu Ile Lys 
    50                  55                  60                  


Leu Asn Arg Lys Thr Leu Val Leu His Leu Leu Arg Ser Arg Glu Phe 
65                  70                  75                  80  


Leu Gly Ser Asn Tyr Ser Glu Thr Phe Tyr Ser Met Lys Gly Glu Ala 
                85                  90                  95      


Phe Thr Arg His Pro Gln Ile Met Asp His Cys Phe Tyr Gln Gly Ser 
            100                 105                 110         


Ile Val His Glu Tyr Asp Ser Ala Ala Ser Ile Ser Thr Cys Asn Gly 
        115                 120                 125             


Leu Arg Gly Phe Phe Arg Ile Asn Asp Gln Arg Tyr Leu Ile Glu Pro 
    130                 135                 140                 


Val Lys Tyr Ser Asp Glu Gly Glu His Leu Val Phe Lys Tyr Asn Leu 
145                 150                 155                 160 


Arg Val Pro Tyr Gly Ala Asn Tyr Ser Cys Thr Glu Leu Asn Phe Thr 
                165                 170                 175     


Arg Lys Thr Val Pro Gly Asp Asn Glu Ser Glu Glu Asp Ser Lys Ile 
            180                 185                 190         


Lys Gly Ile His Asp Glu Lys Tyr Val Glu Leu Phe Ile Val Ala Asp 
        195                 200                 205             


Asp Thr Val Tyr Arg Arg Asn Gly His Pro His Asn Lys Leu Arg Asn 
    210                 215                 220                 


Arg Ile Trp Gly Met Val Asn Phe Val Asn Met Ile Tyr Lys Thr Leu 
225                 230                 235                 240 


Asn Ile His Val Thr Leu Val Gly Ile Glu Ile Trp Thr His Glu Asp 
                245                 250                 255     


Lys Ile Glu Leu Tyr Ser Asn Ile Glu Thr Thr Leu Leu Arg Phe Ser 
            260                 265                 270         


Phe Trp Gln Glu Lys Ile Leu Lys Thr Arg Lys Asp Phe Asp His Val 
        275                 280                 285             


Val Leu Leu Ser Gly Lys Trp Leu Tyr Ser His Val Gln Gly Ile Ser 
    290                 295                 300                 


Tyr Pro Gly Gly Met Cys Leu Pro Tyr Tyr Ser Thr Ser Ile Ile Lys 
305                 310                 315                 320 


Asp Leu Leu Pro Asp Thr Asn Ile Ile Ala Asn Arg Met Ala His Gln 
                325                 330                 335     


Leu Gly His Asn Leu Gly Met Gln His Asp Glu Phe Pro Cys Thr Cys 
            340                 345                 350         


Pro Ser Gly Lys Cys Val Met Asp Ser Asp Gly Ser Ile Pro Ala Leu 
        355                 360                 365             


Lys Phe Ser Lys Cys Ser Gln Asn Gln Tyr His Gln Tyr Leu Lys Asp 
    370                 375                 380                 


Tyr Lys Pro Thr Cys Met Leu Asn Ile Pro Phe Pro Tyr Asn Phe His 
385                 390                 395                 400 


Asp Phe Gln Phe Cys Gly Asn Lys Lys Leu Asp Glu Gly Glu Glu Cys 
                405                 410                 415     


Asp Cys Gly Pro Ala Gln Glu Cys Thr Asn Pro Cys Cys Asp Ala His 
            420                 425                 430         


Thr Cys Val Leu Lys Pro Gly Phe Thr Cys Ala Glu Gly Glu Cys Cys 
        435                 440                 445             


Glu Ser Cys Gln Ile Lys Lys Ala Gly Ser Ile Cys Arg Pro Ala Lys 
    450                 455                 460                 


Asp Glu Cys Asp Phe Pro Glu Met Cys Thr Gly His Ser Pro Ala Cys 
465                 470                 475                 480 


Pro Lys Asp Gln Phe Arg Val Asn Gly Phe Pro Cys Lys Asn Ser Glu 
                485                 490                 495     


Gly Tyr Cys Phe Met Gly Lys Cys Pro Thr Arg Glu Asp Gln Cys Ser 
            500                 505                 510         


Glu Leu Phe Asp Asp Glu Ala Ile Glu Ser His Asp Ile Cys Tyr Lys 
        515                 520                 525             


Met Asn Thr Lys Gly Asn Lys Phe Gly Tyr Cys Lys Asn Lys Glu Asn 
    530                 535                 540                 


Arg Phe Leu Pro Cys Glu Glu Lys Asp Val Arg Cys Gly Lys Ile Tyr 
545                 550                 555                 560 


Cys Thr Gly Gly Glu Leu Ser Ser Leu Leu Gly Glu Asp Lys Thr Tyr 
                565                 570                 575     


His Leu Lys Asp Pro Gln Lys Asn Ala Thr Val Lys Cys Lys Thr Ile 
            580                 585                 590         


Phe Leu Tyr His Asp Ser Thr Asp Ile Gly Leu Val Ala Ser Gly Thr 
        595                 600                 605             


Lys Cys Gly Glu Gly Met Val Cys Asn Asn Gly Glu Cys Leu Asn Met 
    610                 615                 620                 


Glu Lys Val Tyr Ile Ser Thr Asn Cys Pro Ser Gln Cys Asn Glu Asn 
625                 630                 635                 640 


Pro Val Asp Gly His Gly Leu Gln Cys His Cys Glu Glu Gly Gln Ala 
                645                 650                 655     


Pro Val Ala Cys Glu Glu Thr Leu His Val Thr Asn Ile Thr Ile Leu 
            660                 665                 670         


Val Val Val Leu Val Leu Val Ile Val Gly Ile Gly Val Leu Ile Leu 
        675                 680                 685             


Leu Val Arg Tyr Arg Lys Cys Ile Lys Leu Lys Gln Val Gln Ser Pro 
    690                 695                 700                 


Pro Thr Glu Thr Leu Gly Val Glu Asn Lys Gly Tyr Phe Gly Asp Glu 
705                 710                 715                 720 


Gln Gln Ile Arg Thr Glu Pro Ile Leu Pro Glu Ile His Phe Leu Asn 
                725                 730                 735     


Gln Arg Thr Pro Glu Ser Leu Glu Ser Leu Pro Thr Ser Phe Ser Ser 
            740                 745                 750         


Pro His Tyr Ile Thr Leu Lys Pro Ala Ser Lys Asp Ser Arg Gly Ile 
        755                 760                 765             


Ala Asp Pro Asn Gln Ser Ala Lys 
    770                 775     


<210>  299
<211>  210
<212>  PRT
<213>  Homo Sapiens

<400>  299

Met Leu Pro Gly Cys Ile Phe Leu Met Ile Leu Leu Ile Pro Gln Val 
1               5                   10                  15      


Lys Glu Lys Phe Ile Leu Gly Val Glu Gly Gln Gln Leu Val Arg Pro 
            20                  25                  30          


Lys Lys Leu Pro Leu Ile Gln Lys Arg Asp Thr Gly His Thr His Asp 
        35                  40                  45              


Asp Asp Ile Leu Lys Thr Tyr Glu Glu Glu Leu Leu Tyr Glu Ile Lys 
    50                  55                  60                  


Leu Asn Arg Lys Thr Leu Val Leu His Leu Leu Arg Ser Arg Glu Phe 
65                  70                  75                  80  


Leu Gly Ser Asn Tyr Ser Glu Thr Phe Tyr Ser Met Lys Gly Glu Ala 
                85                  90                  95      


Phe Thr Arg His Pro Gln Ile Met Asp His Cys Phe Tyr Gln Gly Ser 
            100                 105                 110         


Ile Val His Glu Tyr Asp Ser Ala Ala Ser Ile Ser Thr Cys Asn Gly 
        115                 120                 125             


Leu Arg Gly Phe Phe Arg Ile Asn Asp Gln Arg Tyr Leu Ile Glu Pro 
    130                 135                 140                 


Val Lys Tyr Ser Asp Glu Gly Glu His Leu Val Phe Lys Tyr Asn Leu 
145                 150                 155                 160 


Arg Val Pro Tyr Gly Ala Asn Tyr Ser Cys Thr Glu Leu Asn Phe Thr 
                165                 170                 175     


Arg Lys Thr Val Pro Gly Asp Asn Glu Ser Glu Glu Asp Ser Lys Ile 
            180                 185                 190         


Lys Val Ser Thr Leu Leu Leu Ser Leu Pro Gln Met Lys His Leu Leu 
        195                 200                 205             


Phe Ser 
    210 


<210>  300
<211>  516
<212>  PRT
<213>  Homo Sapiens

<400>  300

Met Val Asn Phe Val Asn Met Ile Tyr Lys Thr Leu Asn Ile His Val 
1               5                   10                  15      


Thr Leu Val Gly Ile Glu Ile Trp Thr His Glu Asp Lys Ile Glu Leu 
            20                  25                  30          


Tyr Ser Asn Ile Glu Thr Thr Leu Leu Arg Phe Ser Phe Trp Gln Glu 
        35                  40                  45              


Lys Ile Leu Lys Thr Arg Lys Asp Phe Asp His Val Val Leu Leu Ser 
    50                  55                  60                  


Gly Lys Trp Leu Tyr Ser His Val Gln Gly Ile Ser Tyr Pro Gly Gly 
65                  70                  75                  80  


Met Cys Leu Pro Tyr Tyr Ser Thr Ser Ile Ile Lys Asp Leu Leu Pro 
                85                  90                  95      


Asp Thr Asn Ile Ile Ala Asn Arg Met Ala His Gln Leu Gly His Asn 
            100                 105                 110         


Leu Gly Met Gln His Asp Glu Phe Pro Cys Thr Cys Pro Ser Gly Lys 
        115                 120                 125             


Cys Val Met Asp Ser Asp Gly Ser Ile Pro Ala Leu Lys Phe Ser Lys 
    130                 135                 140                 


Cys Ser Gln Asn Gln Tyr His Gln Tyr Leu Lys Asp Tyr Lys Pro Thr 
145                 150                 155                 160 


Cys Met Leu Asn Ile Pro Phe Pro Tyr Asn Phe His Asp Phe Gln Phe 
                165                 170                 175     


Cys Gly Asn Lys Lys Leu Asp Glu Gly Glu Glu Cys Asp Cys Gly Pro 
            180                 185                 190         


Ala Gln Glu Cys Thr Asn Pro Cys Cys Asp Ala His Thr Cys Val Leu 
        195                 200                 205             


Lys Pro Gly Phe Thr Cys Ala Glu Gly Glu Cys Cys Glu Ser Cys Gln 
    210                 215                 220                 


Ile Lys Lys Ala Gly Ser Ile Cys Arg Pro Ala Lys Asp Glu Cys Asp 
225                 230                 235                 240 


Phe Pro Glu Met Cys Thr Gly His Ser Pro Ala Cys Pro Lys Asp Gln 
                245                 250                 255     


Phe Arg Val Asn Gly Phe Pro Cys Lys Asn Ser Glu Gly Tyr Cys Phe 
            260                 265                 270         


Met Gly Lys Cys Pro Thr Arg Glu Asp Gln Cys Ser Glu Leu Phe Asp 
        275                 280                 285             


Asp Glu Ala Ile Glu Ser His Asp Ile Cys Tyr Lys Met Asn Thr Lys 
    290                 295                 300                 


Gly Asn Lys Phe Gly Tyr Cys Lys Asn Lys Glu Asn Arg Phe Leu Pro 
305                 310                 315                 320 


Cys Glu Glu Lys Asp Val Arg Cys Gly Lys Ile Tyr Cys Thr Gly Gly 
                325                 330                 335     


Glu Leu Ser Ser Leu Leu Gly Glu Asp Lys Thr Tyr His Leu Lys Asp 
            340                 345                 350         


Pro Gln Lys Asn Ala Thr Val Lys Cys Lys Thr Ile Phe Leu Tyr His 
        355                 360                 365             


Asp Ser Thr Asp Ile Gly Leu Val Ala Ser Gly Thr Lys Cys Gly Glu 
    370                 375                 380                 


Gly Met Val Cys Asn Asn Gly Glu Cys Leu Asn Met Glu Lys Val Tyr 
385                 390                 395                 400 


Ile Ser Thr Asn Cys Pro Ser Gln Cys Asn Glu Asn Pro Val Asp Gly 
                405                 410                 415     


His Gly Leu Gln Cys His Cys Glu Glu Gly Gln Ala Pro Val Ala Cys 
            420                 425                 430         


Glu Glu Thr Leu His Val Thr Asn Ile Thr Ile Leu Val Val Val Leu 
        435                 440                 445             


Val Leu Val Ile Val Gly Ile Gly Val Leu Ile Leu Leu Val Arg Tyr 
    450                 455                 460                 


Arg Lys Cys Ile Lys Leu Lys Gln Val Gln Ser Pro Pro Thr Glu Thr 
465                 470                 475                 480 


Leu Gly Val Glu Asn Lys Gly Tyr Phe Gly Asp Glu Gln Gln Ile Arg 
                485                 490                 495     


Thr Glu Pro Ile Leu Pro Glu Ile His Phe Leu Asn His Leu Leu Tyr 
            500                 505                 510         


Gly Arg His Gln 
        515     


<210>  301
<211>  245
<212>  PRT
<213>  Homo Sapiens

<400>  301

Met Arg Gly Leu Gly Leu Trp Leu Leu Gly Ala Met Met Leu Pro Ala 
1               5                   10                  15      


Ile Ala Pro Ser Arg Pro Trp Ala Leu Met Glu Gln Tyr Glu Val Val 
            20                  25                  30          


Leu Pro Trp Arg Leu Pro Gly Pro Arg Val Arg Arg Ala Leu Pro Ser 
        35                  40                  45              


His Leu Gly Gly Gln Phe Arg Pro Gln Pro Cys Pro Tyr Leu Ser Ile 
    50                  55                  60                  


Arg Gly Thr Tyr Tyr Arg Pro Ala Arg Cys Pro Gly Leu Ile Gln Pro 
65                  70                  75                  80  


Val Ala Gln Leu Arg Leu Ser Gln Ser Ser Ala Gly Arg Ala Pro Ala 
                85                  90                  95      


Cys Thr Trp Gly Leu Glu Met Gln Trp Ser Ser Arg Arg Leu Cys Arg 
            100                 105                 110         


His His Gln Gly Leu His Pro Glu Arg Val Ser Tyr Val Leu Gly Ala 
        115                 120                 125             


Thr Gly His Asn Phe Thr Leu His Leu Arg Lys Asn Arg Asp Leu Leu 
    130                 135                 140                 


Gly Ser Gly Tyr Thr Glu Thr Tyr Thr Ala Ala Asn Gly Ser Glu Val 
145                 150                 155                 160 


Thr Glu Gln Pro Arg Gly Gln Asp His Cys Phe Tyr Gln Gly His Val 
                165                 170                 175     


Glu Gly Tyr Pro Asp Ser Ala Ala Ser Leu Ser Thr Cys Ala Gly Leu 
            180                 185                 190         


Arg Gly Phe Phe Gln Val Gly Ser Asp Leu His Leu Ile Glu Pro Leu 
        195                 200                 205             


Asp Glu Gly Gly Glu Gly Gly Arg His Ala Val Tyr Gln Ala Glu His 
    210                 215                 220                 


Leu Leu Gln Thr Ala Gly Thr Cys Gly Val Ser Asp Asp Ser Leu Gly 
225                 230                 235                 240 


Ser Leu Leu Gly Pro 
                245 


<210>  302
<211>  742
<212>  PRT
<213>  Homo Sapiens

<400>  302

Met Arg Gly Leu Gly Leu Trp Leu Leu Gly Ala Met Met Leu Pro Ala 
1               5                   10                  15      


Ile Ala Pro Ser Arg Pro Trp Ala Leu Met Glu Gln Tyr Glu Val Val 
            20                  25                  30          


Leu Pro Trp Arg Leu Pro Gly Pro Arg Val Arg Arg Ala Leu Pro Ser 
        35                  40                  45              


His Leu Gly Leu His Pro Glu Arg Val Ser Tyr Val Leu Gly Ala Thr 
    50                  55                  60                  


Gly His Asn Phe Thr Leu His Leu Arg Lys Asn Arg Asp Leu Leu Gly 
65                  70                  75                  80  


Ser Gly Tyr Thr Glu Thr Tyr Thr Ala Ala Asn Gly Ser Glu Val Thr 
                85                  90                  95      


Glu Gln Pro Arg Gly Gln Asp His Cys Phe Tyr Gln Gly His Val Glu 
            100                 105                 110         


Gly Tyr Pro Asp Ser Ala Ala Ser Leu Ser Thr Cys Ala Gly Leu Arg 
        115                 120                 125             


Gly Phe Phe Gln Val Gly Ser Asp Leu His Leu Ile Glu Pro Leu Asp 
    130                 135                 140                 


Glu Gly Gly Glu Gly Gly Arg His Ala Val Tyr Gln Ala Glu His Leu 
145                 150                 155                 160 


Leu Gln Thr Ala Gly Thr Cys Gly Val Ser Asp Asp Ser Leu Gly Ser 
                165                 170                 175     


Leu Leu Gly Pro Arg Thr Ala Ala Val Phe Arg Pro Arg Pro Gly Asp 
            180                 185                 190         


Ser Leu Pro Ser Arg Glu Thr Arg Tyr Val Glu Leu Tyr Val Val Val 
        195                 200                 205             


Asp Asn Ala Glu Phe Gln Met Leu Gly Ser Glu Ala Ala Val Arg His 
    210                 215                 220                 


Arg Val Leu Glu Val Val Asn His Val Asp Lys Leu Tyr Gln Lys Leu 
225                 230                 235                 240 


Asn Phe Arg Val Val Leu Val Gly Leu Glu Ile Trp Asn Ser Gln Asp 
                245                 250                 255     


Arg Phe His Val Ser Pro Asp Pro Ser Val Thr Leu Glu Asn Leu Leu 
            260                 265                 270         


Thr Trp Gln Ala Arg Gln Arg Thr Arg Arg His Leu His Asp Asn Val 
        275                 280                 285             


Gln Leu Ile Thr Gly Val Asp Phe Thr Gly Thr Thr Val Gly Phe Ala 
    290                 295                 300                 


Arg Val Ser Ala Met Cys Ser His Ser Ser Gly Ala Val Asn Gln Asp 
305                 310                 315                 320 


His Ser Lys Asn Pro Val Gly Val Ala Cys Thr Met Ala His Glu Met 
                325                 330                 335     


Gly His Asn Leu Gly Met Asp His Asp Glu Asn Val Gln Gly Cys Arg 
            340                 345                 350         


Cys Gln Glu Arg Phe Glu Ala Gly Arg Cys Ile Met Ala Gly Ser Ile 
        355                 360                 365             


Gly Ser Ser Phe Pro Arg Met Phe Ser Asp Cys Ser Gln Ala Tyr Leu 
    370                 375                 380                 


Glu Ser Phe Leu Glu Arg Pro Gln Ser Val Cys Leu Ala Asn Ala Pro 
385                 390                 395                 400 


Asp Leu Ser His Leu Val Gly Gly Pro Val Cys Gly Asn Leu Phe Val 
                405                 410                 415     


Glu Arg Gly Glu Gln Cys Asp Cys Gly Pro Pro Glu Asp Cys Arg Asn 
            420                 425                 430         


Arg Cys Cys Asn Ser Thr Thr Cys Gln Leu Ala Glu Gly Ala Gln Cys 
        435                 440                 445             


Ala His Gly Thr Cys Cys Gln Glu Cys Lys Val Lys Pro Ala Gly Glu 
    450                 455                 460                 


Leu Cys Arg Pro Lys Lys Asp Met Cys Asp Leu Glu Glu Phe Cys Asp 
465                 470                 475                 480 


Gly Arg His Pro Glu Cys Pro Glu Asp Ala Phe Gln Glu Asn Gly Thr 
                485                 490                 495     


Pro Cys Ser Gly Gly Tyr Cys Tyr Asn Gly Ala Cys Pro Thr Leu Ala 
            500                 505                 510         


Gln Gln Cys Gln Ala Phe Trp Gly Pro Gly Gly Gln Ala Ala Glu Glu 
        515                 520                 525             


Ser Cys Phe Ser Tyr Asp Ile Leu Pro Gly Cys Lys Ala Ser Arg Tyr 
    530                 535                 540                 


Arg Ala Asp Met Cys Gly Val Leu Gln Cys Lys Gly Gly Gln Gln Pro 
545                 550                 555                 560 


Leu Gly Arg Ala Ile Cys Ile Val Asp Val Cys His Ala Leu Thr Thr 
                565                 570                 575     


Glu Asp Gly Thr Ala Tyr Glu Pro Val Pro Glu Gly Thr Arg Cys Gly 
            580                 585                 590         


Pro Glu Lys Val Cys Trp Lys Gly Arg Cys Gln Asp Leu His Val Tyr 
        595                 600                 605             


Arg Ser Ser Asn Cys Ser Ala Gln Cys His Asn His Gly Val Cys Asn 
    610                 615                 620                 


His Lys Gln Glu Cys His Cys His Ala Gly Trp Ala Pro Pro His Cys 
625                 630                 635                 640 


Ala Lys Leu Leu Thr Glu Val His Ala Gly Cys Gln Pro Arg Ala Gly 
                645                 650                 655     


Gln Gly Arg Gly Ser Ser Pro Ile Gln Gly Pro Pro Arg Ala Gly Pro 
            660                 665                 670         


His His Pro Pro Gly Pro Ala Arg Pro Thr Pro Gly Leu Leu Gly Gly 
        675                 680                 685             


Ser Glu Glu Ala Ala Pro Cys Ser Ser Gly His Cys Val Gln Pro Thr 
    690                 695                 700                 


Leu Pro Ser Ser Cys Leu His Pro Ala Gly Thr Lys Ala Gly His Gln 
705                 710                 715                 720 


Ala Asn Val Arg Thr Pro Ser Ala Pro Ser Gln Thr Arg Gly Trp Cys 
                725                 730                 735     


Gly Gln Pro Trp Ser Ser 
            740         


<210>  303
<211>  824
<212>  PRT
<213>  Homo Sapiens

<400>  303

Met Arg Gly Leu Gly Leu Trp Leu Leu Gly Ala Met Met Leu Pro Ala 
1               5                   10                  15      


Ile Ala Pro Ser Arg Pro Trp Ala Leu Met Glu Gln Tyr Glu Val Val 
            20                  25                  30          


Leu Pro Trp Arg Leu Pro Gly Pro Arg Val Arg Arg Ala Leu Pro Ser 
        35                  40                  45              


His Leu Gly Leu His Pro Glu Arg Val Ser Tyr Val Leu Gly Ala Thr 
    50                  55                  60                  


Gly His Asn Phe Thr Leu His Leu Arg Lys Asn Arg Asp Leu Leu Gly 
65                  70                  75                  80  


Ser Gly Tyr Thr Glu Thr Tyr Thr Ala Ala Asn Gly Ser Glu Val Thr 
                85                  90                  95      


Glu Gln Pro Arg Gly Gln Asp His Cys Phe Tyr Gln Gly His Val Glu 
            100                 105                 110         


Gly Tyr Pro Asp Ser Ala Ala Ser Leu Ser Thr Cys Ala Gly Leu Arg 
        115                 120                 125             


Gly Phe Phe Gln Val Gly Ser Asp Leu His Leu Ile Glu Pro Leu Asp 
    130                 135                 140                 


Glu Gly Gly Glu Gly Gly Arg His Ala Val Tyr Gln Ala Glu His Leu 
145                 150                 155                 160 


Leu Gln Thr Ala Gly Thr Cys Gly Val Ser Asp Asp Ser Leu Gly Ser 
                165                 170                 175     


Leu Leu Gly Pro Arg Thr Ala Ala Val Phe Arg Pro Arg Pro Gly Asp 
            180                 185                 190         


Ser Leu Pro Ser Arg Glu Thr Arg Tyr Val Glu Leu Tyr Val Val Val 
        195                 200                 205             


Asp Asn Ala Glu Phe Gln Met Leu Gly Ser Glu Ala Ala Val Arg His 
    210                 215                 220                 


Arg Val Leu Glu Val Val Asn His Val Asp Lys Leu Tyr Gln Lys Leu 
225                 230                 235                 240 


Asn Phe Arg Val Val Leu Val Gly Leu Glu Ile Trp Asn Ser Gln Asp 
                245                 250                 255     


Arg Phe His Val Ser Pro Asp Pro Ser Val Thr Leu Glu Asn Leu Leu 
            260                 265                 270         


Thr Trp Gln Ala Arg Gln Arg Thr Arg Arg His Leu His Asp Asn Val 
        275                 280                 285             


Gln Leu Ile Thr Gly Val Asp Phe Thr Gly Thr Thr Val Gly Phe Ala 
    290                 295                 300                 


Arg Val Ser Ala Met Cys Ser His Ser Ser Gly Ala Val Asn Gln Asp 
305                 310                 315                 320 


His Ser Lys Asn Pro Val Gly Val Ala Cys Thr Met Ala His Glu Met 
                325                 330                 335     


Gly His Asn Leu Gly Met Asp His Asp Glu Asn Val Gln Gly Cys Arg 
            340                 345                 350         


Cys Gln Glu Arg Phe Glu Ala Gly Arg Cys Ile Met Ala Gly Ser Ile 
        355                 360                 365             


Gly Ser Ser Phe Pro Arg Met Phe Ser Asp Cys Ser Gln Ala Tyr Leu 
    370                 375                 380                 


Glu Ser Phe Leu Glu Arg Pro Gln Ser Val Cys Leu Ala Asn Ala Pro 
385                 390                 395                 400 


Asp Leu Ser His Leu Val Gly Gly Pro Val Cys Gly Asn Leu Phe Val 
                405                 410                 415     


Glu Arg Gly Glu Gln Cys Asp Cys Gly Pro Pro Glu Asp Cys Arg Asn 
            420                 425                 430         


Arg Cys Cys Asn Ser Thr Thr Cys Gln Leu Ala Glu Gly Ala Gln Cys 
        435                 440                 445             


Ala His Gly Thr Cys Cys Gln Glu Cys Lys Val Lys Pro Ala Gly Glu 
    450                 455                 460                 


Leu Cys Arg Pro Lys Lys Asp Met Cys Asp Leu Glu Glu Phe Cys Asp 
465                 470                 475                 480 


Gly Arg His Pro Glu Cys Pro Glu Asp Ala Phe Gln Glu Asn Gly Thr 
                485                 490                 495     


Pro Cys Ser Gly Gly Tyr Cys Tyr Asn Gly Ala Cys Pro Thr Leu Ala 
            500                 505                 510         


Gln Gln Cys Gln Ala Phe Trp Gly Pro Gly Gly Gln Ala Ala Glu Glu 
        515                 520                 525             


Ser Cys Phe Ser Tyr Asp Ile Leu Pro Gly Cys Lys Ala Ser Arg Tyr 
    530                 535                 540                 


Arg Ala Asp Met Cys Gly Val Leu Gln Cys Lys Gly Gly Gln Gln Pro 
545                 550                 555                 560 


Leu Gly Arg Ala Ile Cys Ile Val Asp Val Cys His Ala Leu Thr Thr 
                565                 570                 575     


Glu Asp Gly Thr Ala Tyr Glu Pro Val Pro Glu Gly Thr Arg Cys Gly 
            580                 585                 590         


Pro Glu Lys Val Cys Trp Lys Gly Arg Cys Gln Asp Leu His Val Tyr 
        595                 600                 605             


Arg Ser Ser Asn Cys Ser Ala Gln Cys His Asn His Gly Val Cys Asn 
    610                 615                 620                 


His Lys Gln Glu Cys His Cys His Ala Gly Trp Ala Pro Pro His Cys 
625                 630                 635                 640 


Ala Lys Leu Leu Thr Glu Val His Ala Ala Ser Gly Ser Leu Pro Val 
                645                 650                 655     


Phe Val Val Val Val Leu Val Leu Leu Ala Val Val Leu Val Thr Leu 
            660                 665                 670         


Ala Gly Ile Ile Val Tyr Arg Lys Ala Arg Ser Arg Ile Leu Ser Arg 
        675                 680                 685             


Asn Val Ala Pro Lys Thr Thr Met Gly Arg Ser Asn Pro Leu Phe His 
    690                 695                 700                 


Gln Ala Ala Ser Arg Val Pro Ala Lys Gly Gly Ala Pro Ala Pro Ser 
705                 710                 715                 720 


Arg Gly Pro Gln Glu Leu Val Pro Thr Thr His Pro Gly Gln Pro Ala 
                725                 730                 735     


Arg His Pro Ala Ser Ser Val Ala Leu Lys Arg Pro Pro Pro Ala Pro 
            740                 745                 750         


Pro Val Thr Val Ser Ser Pro Pro Phe Pro Val Pro Val Tyr Thr Arg 
        755                 760                 765             


Gln Ala Pro Lys Gln Val Ile Lys Pro Thr Phe Ala Pro Pro Val Pro 
    770                 775                 780                 


Pro Val Lys Pro Gly Ala Gly Ala Ala Asn Pro Gly Pro Ala Glu Gly 
785                 790                 795                 800 


Ala Val Gly Pro Lys Val Ala Leu Lys Pro Pro Ile Gln Arg Lys Gln 
                805                 810                 815     


Gly Ala Gly Ala Pro Thr Ala Pro 
            820                 


<210>  304
<211>  109
<212>  PRT
<213>  Homo Sapiens

<400>  304

Met Arg Gly Leu Gly Leu Trp Leu Leu Gly Ala Met Met Leu Pro Gly 
1               5                   10                  15      


Pro Ala Pro Arg Glu Gly Glu Leu Arg Pro Trp Gly His Arg Ala Gln 
            20                  25                  30          


Leu His Pro Pro Pro Ala Glu Glu Gln Gly Pro Ala Gly Leu Arg Leu 
        35                  40                  45              


His Arg Asp Leu Tyr Gly Cys Gln Trp Leu Arg Gly Asp Gly Ala Ala 
    50                  55                  60                  


Ser Arg Ala Gly Pro Leu Leu Leu Pro Gly Pro Arg Arg Gly Val Pro 
65                  70                  75                  80  


Gly Leu Ser Arg Gln Pro Gln His Leu Cys Arg Pro Gln Gly Phe Leu 
                85                  90                  95      


Pro Gly Gly Val Arg Pro Ala Pro Asp Arg Ala Pro Gly 
            100                 105                 


<210>  305
<211>  733
<212>  PRT
<213>  Homo Sapiens

<400>  305

Met Arg Gly Leu Gly Leu Trp Leu Leu Gly Ala Met Met Leu Pro Gly 
1               5                   10                  15      


Pro Ala Pro Arg Glu Gly Glu Leu Arg Pro Trp Gly His Arg Ala Gln 
            20                  25                  30          


Leu His Pro Pro Pro Ala Glu Glu Gln Gly Pro Ala Gly Leu Arg Leu 
        35                  40                  45              


His Arg Asp Leu Tyr Gly Cys Gln Trp Leu Arg Gly Asp Gly Ala Ala 
    50                  55                  60                  


Ser Arg Ala Gly Pro Leu Leu Leu Pro Gly Pro Arg Arg Gly Val Pro 
65                  70                  75                  80  


Gly Leu Ser Arg Gln Pro Gln His Leu Cys Arg Pro Gln Val Gly Ser 
                85                  90                  95      


Asp Leu His Leu Ile Glu Pro Leu Asp Glu Gly Gly Glu Gly Gly Arg 
            100                 105                 110         


His Ala Val Tyr Gln Ala Glu His Leu Leu Gln Thr Ala Gly Thr Cys 
        115                 120                 125             


Gly Val Ser Asp Asp Ser Leu Gly Ser Leu Leu Gly Pro Arg Thr Ala 
    130                 135                 140                 


Ala Val Phe Arg Pro Arg Pro Gly Asp Ser Leu Pro Ser Arg Glu Thr 
145                 150                 155                 160 


Arg Tyr Val Glu Leu Tyr Val Val Val Asp Asn Ala Glu Phe Gln Met 
                165                 170                 175     


Leu Gly Ser Glu Ala Ala Val Arg His Arg Val Leu Glu Val Val Asn 
            180                 185                 190         


His Val Asp Lys Leu Tyr Gln Lys Leu Asn Phe Arg Val Val Leu Val 
        195                 200                 205             


Gly Leu Glu Ile Trp Asn Ser Gln Asp Arg Phe His Val Ser Pro Asp 
    210                 215                 220                 


Pro Ser Val Thr Leu Glu Asn Leu Leu Thr Trp Gln Ala Arg Gln Arg 
225                 230                 235                 240 


Thr Arg Arg His Leu His Asp Asn Val Gln Leu Ile Thr Gly Val Asp 
                245                 250                 255     


Phe Thr Gly Thr Thr Val Gly Phe Ala Arg Val Ser Ala Met Cys Ser 
            260                 265                 270         


His Ser Ser Gly Ala Val Asn Gln Asp His Ser Lys Asn Pro Val Gly 
        275                 280                 285             


Val Ala Cys Thr Met Ala His Glu Met Gly His Asn Leu Gly Met Asp 
    290                 295                 300                 


His Asp Glu Asn Val Gln Gly Cys Arg Cys Gln Glu Arg Phe Glu Ala 
305                 310                 315                 320 


Gly Arg Cys Ile Met Ala Gly Ser Ile Gly Ser Ser Phe Pro Arg Met 
                325                 330                 335     


Phe Ser Asp Cys Ser Gln Ala Tyr Leu Glu Ser Phe Leu Glu Arg Pro 
            340                 345                 350         


Gln Ser Val Cys Leu Ala Asn Ala Pro Asp Leu Ser His Leu Val Gly 
        355                 360                 365             


Gly Pro Val Cys Gly Asn Leu Phe Val Glu Arg Gly Glu Gln Cys Asp 
    370                 375                 380                 


Cys Gly Pro Pro Glu Asp Cys Arg Asn Arg Cys Cys Asn Ser Thr Thr 
385                 390                 395                 400 


Cys Gln Leu Ala Glu Gly Ala Gln Cys Ala His Gly Thr Cys Cys Gln 
                405                 410                 415     


Glu Cys Lys Val Lys Pro Ala Gly Glu Leu Cys Arg Pro Lys Lys Asp 
            420                 425                 430         


Met Cys Asp Leu Glu Glu Phe Cys Asp Gly Arg His Pro Glu Cys Pro 
        435                 440                 445             


Glu Asp Ala Phe Gln Glu Asn Gly Thr Pro Cys Ser Gly Gly Tyr Cys 
    450                 455                 460                 


Tyr Asn Gly Ala Cys Pro Thr Leu Ala Gln Gln Cys Gln Ala Phe Trp 
465                 470                 475                 480 


Gly Pro Gly Gly Gln Ala Ala Glu Glu Ser Cys Phe Ser Tyr Asp Ile 
                485                 490                 495     


Leu Pro Gly Cys Lys Ala Ser Arg Tyr Arg Ala Asp Met Cys Gly Val 
            500                 505                 510         


Leu Gln Cys Lys Gly Gly Gln Gln Pro Leu Gly Arg Ala Ile Cys Ile 
        515                 520                 525             


Val Asp Val Cys His Ala Leu Thr Thr Glu Asp Gly Thr Ala Tyr Glu 
    530                 535                 540                 


Pro Val Pro Glu Gly Thr Arg Cys Gly Pro Glu Lys Val Cys Asn His 
545                 550                 555                 560 


Lys Gln Glu Cys His Cys His Ala Gly Trp Ala Pro Pro His Cys Ala 
                565                 570                 575     


Lys Leu Leu Thr Glu Val His Ala Ala Ser Gly Ser Leu Pro Val Phe 
            580                 585                 590         


Val Val Val Val Leu Val Leu Leu Ala Val Val Leu Val Thr Leu Ala 
        595                 600                 605             


Gly Ile Ile Val Tyr Arg Lys Ala Arg Ser Arg Ile Leu Ser Arg Asn 
    610                 615                 620                 


Val Ala Pro Lys Thr Thr Met Gly Arg Ser Asn Pro Leu Phe His Gln 
625                 630                 635                 640 


Ala Ala Ser Arg Val Pro Ala Lys Gly Gly Ala Pro Ala Pro Ser Arg 
                645                 650                 655     


Gly Pro Gln Glu Leu Val Pro Thr Thr His Pro Gly Gln Pro Ala Arg 
            660                 665                 670         


His Pro Ala Ser Ser Val Ala Leu Lys Arg Pro Pro Pro Ala Pro Pro 
        675                 680                 685             


Val Thr Val Ser Ser Pro Pro Phe Pro Val Pro Val Tyr Thr Arg Gln 
    690                 695                 700                 


Ala Pro Lys Gln Gly Ala Val Gly Pro Lys Val Ala Leu Lys Pro Pro 
705                 710                 715                 720 


Ile Gln Arg Lys Gln Gly Ala Gly Ala Pro Thr Ala Pro 
                725                 730             


<210>  306
<211>  655
<212>  PRT
<213>  Homo Sapiens

<400>  306

Met Gly Ser Gly Ala Arg Phe Pro Ser Gly Thr Leu Arg Val Arg Trp 
1               5                   10                  15      


Leu Leu Leu Leu Gly Leu Val Gly Pro Val Leu Gly Ala Ala Arg Pro 
            20                  25                  30          


Gly Phe Gln Gln Thr Ser His Leu Ser Ser Tyr Glu Ile Ile Thr Pro 
        35                  40                  45              


Trp Arg Leu Thr Arg Glu Arg Arg Glu Ala Pro Arg Pro Tyr Ser Lys 
    50                  55                  60                  


Gln Val Ser Tyr Val Ile Gln Ala Glu Gly Lys Glu His Ile Ile His 
65                  70                  75                  80  


Leu Glu Arg Asn Lys Asp Leu Leu Pro Glu Asp Phe Val Val Tyr Thr 
                85                  90                  95      


Tyr Asn Lys Glu Gly Thr Leu Ile Thr Asp His Pro Asn Ile Gln Asn 
            100                 105                 110         


His Cys His Tyr Arg Gly Tyr Val Glu Gly Val His Asn Ser Ser Ile 
        115                 120                 125             


Ala Leu Ser Asp Cys Phe Gly Leu Arg Gly Leu Leu His Leu Glu Asn 
    130                 135                 140                 


Ala Ser Tyr Gly Ile Glu Pro Leu Gln Asn Ser Ser His Phe Glu His 
145                 150                 155                 160 


Ile Ile Tyr Arg Met Asp Asp Val Tyr Lys Glu Pro Leu Lys Cys Gly 
                165                 170                 175     


Val Ser Asn Lys Asp Ile Glu Lys Glu Thr Ala Lys Asp Glu Glu Glu 
            180                 185                 190         


Glu Pro Pro Ser Met Thr Gln Leu Leu Arg Arg Arg Arg Ala Val Leu 
        195                 200                 205             


Pro Gln Thr Arg Tyr Val Glu Leu Phe Ile Val Val Asp Lys Glu Arg 
    210                 215                 220                 


Tyr Asp Met Met Gly Arg Asn Gln Thr Ala Val Arg Glu Glu Met Ile 
225                 230                 235                 240 


Leu Leu Ala Asn Tyr Leu Asp Ser Met Tyr Ile Met Leu Asn Ile Arg 
                245                 250                 255     


Ile Val Leu Val Gly Leu Glu Ile Trp Thr Asn Gly Asn Leu Ile Asn 
            260                 265                 270         


Ile Val Gly Gly Ala Gly Asp Val Leu Gly Asn Phe Val Gln Trp Arg 
        275                 280                 285             


Glu Lys Phe Leu Ile Thr Arg Arg Arg His Asp Ser Ala Gln Leu Val 
    290                 295                 300                 


Leu Lys Lys Gly Phe Gly Gly Thr Ala Gly Met Ala Phe Val Gly Thr 
305                 310                 315                 320 


Val Cys Ser Arg Ser His Ala Gly Gly Ile Asn Val Phe Gly Gln Ile 
                325                 330                 335     


Thr Val Glu Thr Phe Ala Ser Ile Val Ala His Glu Leu Gly His Asn 
            340                 345                 350         


Leu Gly Met Asn His Asp Asp Gly Arg Asp Cys Ser Cys Gly Ala Lys 
        355                 360                 365             


Ser Cys Ile Met Asn Ser Gly Ala Ser Gly Ser Arg Asn Phe Ser Ser 
    370                 375                 380                 


Cys Ser Ala Glu Asp Phe Glu Lys Leu Thr Leu Asn Lys Gly Gly Asn 
385                 390                 395                 400 


Cys Leu Leu Asn Ile Pro Lys Pro Asp Glu Ala Tyr Ser Ala Pro Ser 
                405                 410                 415     


Cys Gly Asn Lys Leu Val Asp Ala Gly Glu Glu Cys Asp Cys Gly Thr 
            420                 425                 430         


Pro Lys Glu Cys Glu Leu Asp Pro Cys Cys Glu Gly Ser Thr Cys Lys 
        435                 440                 445             


Leu Lys Ser Phe Ala Glu Cys Ala Tyr Gly Asp Cys Cys Lys Asp Cys 
    450                 455                 460                 


Arg Phe Leu Pro Gly Gly Thr Leu Cys Arg Gly Lys Thr Ser Glu Cys 
465                 470                 475                 480 


Asp Val Pro Glu Tyr Cys Asn Gly Ser Ser Gln Phe Cys Gln Pro Asp 
                485                 490                 495     


Val Phe Ile Gln Asn Gly Tyr Pro Cys Gln Asn Asn Lys Ala Tyr Cys 
            500                 505                 510         


Tyr Asn Gly Met Cys Gln Tyr Tyr Asp Ala Gln Cys Gln Val Ile Phe 
        515                 520                 525             


Gly Ser Lys Ala Lys Ala Ala Pro Lys Asp Cys Phe Ile Glu Val Asn 
    530                 535                 540                 


Ser Lys Gly Asp Arg Phe Gly Asn Cys Gly Phe Ser Gly Asn Glu Tyr 
545                 550                 555                 560 


Lys Lys Cys Ala Thr Gly Asn Ala Leu Cys Gly Lys Leu Gln Cys Glu 
                565                 570                 575     


Asn Val Gln Glu Ile Pro Val Phe Gly Ile Val Pro Ala Ile Ile Gln 
            580                 585                 590         


Thr Pro Ser Arg Gly Thr Lys Cys Trp Gly Val Asp Phe Gln Leu Gly 
        595                 600                 605             


Ser Asp Val Pro Asp Pro Gly Met Val Asn Glu Gly Thr Lys Cys Gly 
    610                 615                 620                 


Ala Gly Lys Ile Cys Arg Asn Phe Gln Cys Val Asp Ala Ser Val Leu 
625                 630                 635                 640 


Asn Tyr Asp Cys Asp Val Gln Lys Lys Cys His Gly His Gly Lys 
                645                 650                 655 


<210>  307
<211>  628
<212>  PRT
<213>  Homo Sapiens

<400>  307

Met Gly Ser Gly Ala Arg Phe Pro Ser Gly Thr Leu Arg Val Arg Trp 
1               5                   10                  15      


Leu Leu Leu Leu Gly Leu Val Gly Pro Val Leu Gly Ala Ala Arg Pro 
            20                  25                  30          


Gly Phe Gln Gln Thr Ser His Leu Ser Ser Tyr Glu Ile Ile Thr Pro 
        35                  40                  45              


Trp Arg Leu Thr Arg Glu Arg Arg Glu Ala Pro Arg Pro Tyr Ser Lys 
    50                  55                  60                  


Gln Val Ser Tyr Val Ile Gln Ala Glu Gly Lys Glu His Ile Ile His 
65                  70                  75                  80  


Leu Glu Arg Asn Lys Asp Leu Leu Pro Glu Asp Phe Val Val Tyr Thr 
                85                  90                  95      


Tyr Asn Lys Glu Gly Thr Leu Ile Thr Asp His Pro Asn Ile Gln Asn 
            100                 105                 110         


His Cys His Tyr Arg Gly Tyr Val Glu Gly Val His Asn Ser Ser Ile 
        115                 120                 125             


Ala Leu Ser Asp Cys Phe Gly Leu Arg Gly Leu Leu His Leu Glu Asn 
    130                 135                 140                 


Ala Ser Tyr Gly Ile Glu Pro Leu Gln Asn Ser Ser His Phe Glu His 
145                 150                 155                 160 


Ile Ile Tyr Arg Met Asp Asp Val Tyr Lys Glu Pro Leu Lys Cys Gly 
                165                 170                 175     


Val Ser Asn Lys Asp Ile Glu Lys Glu Thr Ala Lys Asp Glu Glu Glu 
            180                 185                 190         


Glu Pro Pro Ser Met Thr Gln Leu Leu Arg Arg Arg Arg Ala Val Leu 
        195                 200                 205             


Pro Gln Thr Arg Tyr Val Glu Leu Phe Ile Val Val Asp Lys Glu Arg 
    210                 215                 220                 


Tyr Asp Met Met Gly Arg Asn Gln Thr Ala Val Arg Glu Glu Met Ile 
225                 230                 235                 240 


Leu Leu Ala Asn Tyr Leu Asp Ser Met Tyr Ile Met Leu Asn Ile Arg 
                245                 250                 255     


Ile Val Leu Val Gly Leu Glu Ile Trp Thr Asn Gly Asn Leu Ile Asn 
            260                 265                 270         


Ile Val Gly Gly Ala Gly Asp Val Leu Gly Asn Phe Val Gln Trp Arg 
        275                 280                 285             


Glu Lys Phe Leu Ile Thr Arg Arg Arg His Asp Ser Ala Gln Leu Val 
    290                 295                 300                 


Leu Lys Lys Gly Phe Gly Gly Thr Ala Gly Met Ala Phe Val Gly Thr 
305                 310                 315                 320 


Val Cys Ser Arg Ser His Ala Gly Gly Ile Asn Val Phe Gly Gln Ile 
                325                 330                 335     


Thr Val Glu Thr Phe Ala Ser Ile Val Ala His Glu Leu Gly His Asn 
            340                 345                 350         


Leu Gly Met Asn His Asp Asp Gly Arg Asp Cys Ser Cys Gly Ala Lys 
        355                 360                 365             


Ser Cys Ile Met Asn Ser Gly Ala Ser Gly Ser Arg Asn Phe Ser Ser 
    370                 375                 380                 


Cys Ser Ala Glu Asp Phe Glu Lys Leu Thr Leu Asn Lys Gly Gly Asn 
385                 390                 395                 400 


Cys Leu Leu Asn Ile Pro Lys Pro Asp Glu Ala Tyr Ser Ala Pro Ser 
                405                 410                 415     


Cys Gly Asn Lys Leu Val Asp Ala Gly Glu Glu Cys Asp Cys Gly Thr 
            420                 425                 430         


Pro Lys Glu Cys Glu Leu Asp Pro Cys Cys Glu Gly Ser Thr Cys Lys 
        435                 440                 445             


Leu Lys Ser Phe Ala Glu Cys Ala Tyr Gly Asp Cys Cys Lys Asp Cys 
    450                 455                 460                 


Arg Phe Leu Pro Gly Gly Thr Leu Cys Arg Gly Lys Thr Ser Glu Cys 
465                 470                 475                 480 


Asp Val Pro Glu Tyr Cys Asn Gly Ser Ser Gln Phe Cys Gln Pro Asp 
                485                 490                 495     


Val Phe Ile Gln Asn Gly Tyr Pro Cys Gln Asn Asn Lys Ala Tyr Cys 
            500                 505                 510         


Tyr Asn Gly Met Cys Gln Tyr Tyr Asp Ala Gln Cys Gln Val Ile Phe 
        515                 520                 525             


Gly Ser Lys Ala Lys Ala Ala Pro Lys Asp Cys Phe Ile Glu Val Asn 
    530                 535                 540                 


Ser Lys Gly Asp Arg Phe Gly Asn Cys Gly Phe Ser Gly Asn Glu Tyr 
545                 550                 555                 560 


Lys Lys Cys Ala Thr Gly Asn Ala Leu Cys Gly Lys Leu Gln Cys Glu 
                565                 570                 575     


Asn Val Gln Glu Ile Pro Val Phe Gly Ile Val Pro Ala Ile Ile Gln 
            580                 585                 590         


Thr Pro Ser Arg Gly Thr Lys Cys Trp Gly Val Asp Phe Gln Leu Gly 
        595                 600                 605             


Ser Asp Val Pro Asp Pro Gly Met Val Asn Glu Gly Thr Lys Cys Gly 
    610                 615                 620                 


Ala Gly Lys Lys 
625             


<210>  308
<211>  819
<212>  PRT
<213>  Homo Sapiens

<400>  308

Met Gly Ser Gly Ala Arg Phe Pro Ser Gly Thr Leu Arg Val Arg Trp 
1               5                   10                  15      


Leu Leu Leu Leu Gly Leu Val Gly Pro Val Leu Gly Ala Ala Arg Pro 
            20                  25                  30          


Gly Phe Gln Gln Thr Ser His Leu Ser Ser Tyr Glu Ile Ile Thr Pro 
        35                  40                  45              


Trp Arg Leu Thr Arg Glu Arg Arg Glu Ala Pro Arg Pro Tyr Ser Lys 
    50                  55                  60                  


Gln Val Ser Tyr Val Ile Gln Ala Glu Gly Lys Glu His Ile Ile His 
65                  70                  75                  80  


Leu Glu Arg Asn Lys Asp Leu Leu Pro Glu Asp Phe Val Val Tyr Thr 
                85                  90                  95      


Tyr Asn Lys Glu Gly Thr Leu Ile Thr Asp His Pro Asn Ile Gln Asn 
            100                 105                 110         


His Cys His Tyr Arg Gly Tyr Val Glu Gly Val His Asn Ser Ser Ile 
        115                 120                 125             


Ala Leu Ser Asp Cys Phe Gly Leu Arg Gly Leu Leu His Leu Glu Asn 
    130                 135                 140                 


Ala Ser Tyr Gly Ile Glu Pro Leu Gln Asn Ser Ser His Phe Glu His 
145                 150                 155                 160 


Ile Ile Tyr Arg Met Asp Asp Val Tyr Lys Glu Pro Leu Lys Cys Gly 
                165                 170                 175     


Val Ser Asn Lys Asp Ile Glu Lys Glu Thr Ala Lys Asp Glu Glu Glu 
            180                 185                 190         


Glu Pro Pro Ser Met Thr Gln Leu Leu Arg Arg Arg Arg Ala Val Leu 
        195                 200                 205             


Pro Gln Thr Arg Tyr Val Glu Leu Phe Ile Val Val Asp Lys Glu Arg 
    210                 215                 220                 


Tyr Asp Met Met Gly Arg Asn Gln Thr Ala Val Arg Glu Glu Met Ile 
225                 230                 235                 240 


Leu Leu Ala Asn Tyr Leu Asp Ser Met Tyr Ile Met Leu Asn Ile Arg 
                245                 250                 255     


Ile Val Leu Val Gly Leu Glu Ile Trp Thr Asn Gly Asn Leu Ile Asn 
            260                 265                 270         


Ile Val Gly Gly Ala Gly Asp Val Leu Gly Asn Phe Val Gln Trp Arg 
        275                 280                 285             


Glu Lys Phe Leu Ile Thr Arg Arg Arg His Asp Ser Ala Gln Leu Val 
    290                 295                 300                 


Leu Lys Lys Gly Phe Gly Gly Thr Ala Gly Met Ala Phe Val Gly Thr 
305                 310                 315                 320 


Val Cys Ser Arg Ser His Ala Gly Gly Ile Asn Val Phe Gly Gln Ile 
                325                 330                 335     


Thr Val Glu Thr Phe Ala Ser Ile Val Ala His Glu Leu Gly His Asn 
            340                 345                 350         


Leu Gly Met Asn His Asp Asp Gly Arg Asp Cys Ser Cys Gly Ala Lys 
        355                 360                 365             


Ser Cys Ile Met Asn Ser Gly Ala Ser Gly Ser Arg Asn Phe Ser Ser 
    370                 375                 380                 


Cys Ser Ala Glu Asp Phe Glu Lys Leu Thr Leu Asn Lys Gly Gly Asn 
385                 390                 395                 400 


Cys Leu Leu Asn Ile Pro Lys Pro Asp Glu Ala Tyr Ser Ala Pro Ser 
                405                 410                 415     


Cys Gly Asn Lys Leu Val Asp Ala Gly Glu Glu Cys Asp Cys Gly Thr 
            420                 425                 430         


Pro Lys Glu Cys Glu Leu Asp Pro Cys Cys Glu Gly Ser Thr Cys Lys 
        435                 440                 445             


Leu Lys Ser Phe Ala Glu Cys Ala Tyr Gly Asp Cys Cys Lys Asp Cys 
    450                 455                 460                 


Arg Phe Leu Pro Gly Gly Thr Leu Cys Arg Gly Lys Thr Ser Glu Cys 
465                 470                 475                 480 


Asp Val Pro Glu Tyr Cys Asn Gly Ser Ser Gln Phe Cys Gln Pro Asp 
                485                 490                 495     


Val Phe Ile Gln Asn Gly Tyr Pro Cys Gln Asn Asn Lys Ala Tyr Cys 
            500                 505                 510         


Tyr Asn Gly Met Cys Gln Tyr Tyr Asp Ala Gln Cys Gln Val Ile Phe 
        515                 520                 525             


Gly Ser Lys Ala Lys Ala Ala Pro Lys Asp Cys Phe Ile Glu Val Asn 
    530                 535                 540                 


Ser Lys Gly Asp Arg Phe Gly Asn Cys Gly Phe Ser Gly Asn Glu Tyr 
545                 550                 555                 560 


Lys Lys Cys Ala Thr Gly Asn Ala Leu Cys Gly Lys Leu Gln Cys Glu 
                565                 570                 575     


Asn Val Gln Glu Ile Pro Val Phe Gly Ile Val Pro Ala Ile Ile Gln 
            580                 585                 590         


Thr Pro Ser Arg Gly Thr Lys Cys Trp Gly Val Asp Phe Gln Leu Gly 
        595                 600                 605             


Ser Asp Val Pro Asp Pro Gly Met Val Asn Glu Gly Thr Lys Cys Gly 
    610                 615                 620                 


Ala Gly Lys Ile Cys Arg Asn Phe Gln Cys Val Asp Ala Ser Val Leu 
625                 630                 635                 640 


Asn Tyr Asp Cys Asp Val Gln Lys Lys Cys His Gly His Gly Val Cys 
                645                 650                 655     


Asn Ser Asn Lys Asn Cys His Cys Glu Asn Gly Trp Ala Pro Pro Asn 
            660                 665                 670         


Cys Glu Thr Lys Gly Tyr Gly Gly Ser Val Asp Ser Gly Pro Thr Tyr 
        675                 680                 685             


Asn Glu Met Asn Thr Ala Leu Arg Asp Gly Leu Leu Val Phe Phe Phe 
    690                 695                 700                 


Leu Ile Val Pro Leu Ile Val Cys Ala Ile Phe Ile Phe Ile Lys Arg 
705                 710                 715                 720 


Asp Gln Leu Trp Arg Ser Tyr Phe Arg Lys Lys Arg Ser Gln Thr Tyr 
                725                 730                 735     


Glu Ser Asp Gly Lys Asn Gln Ala Asn Pro Ser Arg Gln Pro Gly Ser 
            740                 745                 750         


Val Pro Arg His Val Ser Pro Val Thr Pro Pro Arg Glu Val Pro Ile 
        755                 760                 765             


Tyr Ala Asn Arg Phe Ala Val Pro Thr Tyr Ala Ala Lys Gln Pro Gln 
    770                 775                 780                 


Gln Phe Pro Ser Arg Pro Pro Pro Pro Gln Pro Lys Val Ser Ser Gln 
785                 790                 795                 800 


Gly Asn Leu Ile Pro Ala Arg Pro Ala Pro Ala Pro Pro Leu Tyr Ser 
                805                 810                 815     


Ser Leu Thr 
            


<210>  309
<211>  712
<212>  PRT
<213>  Homo Sapiens

<400>  309

Met Gly Ser Gly Ala Arg Phe Pro Ser Gly Thr Leu Arg Val Arg Trp 
1               5                   10                  15      


Leu Leu Leu Leu Gly Leu Val Gly Pro Val Leu Gly Ala Ala Arg Pro 
            20                  25                  30          


Gly Phe Gln Gln Thr Ser His Leu Ser Ser Tyr Glu Ile Ile Thr Pro 
        35                  40                  45              


Trp Arg Leu Thr Arg Glu Arg Arg Glu Ala Pro Arg Pro Tyr Ser Lys 
    50                  55                  60                  


Gln Val Ser Tyr Val Ile Gln Ala Glu Gly Lys Glu His Ile Ile His 
65                  70                  75                  80  


Leu Glu Arg Asn Lys Asp Leu Leu Pro Glu Asp Phe Val Val Tyr Thr 
                85                  90                  95      


Tyr Asn Lys Glu Gly Thr Leu Ile Thr Asp His Pro Asn Ile Gln Asn 
            100                 105                 110         


His Cys His Tyr Arg Gly Tyr Val Glu Gly Val His Asn Ser Ser Ile 
        115                 120                 125             


Ala Leu Ser Asp Cys Phe Gly Leu Arg Gly Leu Leu His Leu Glu Asn 
    130                 135                 140                 


Ala Ser Tyr Gly Ile Glu Pro Leu Gln Asn Ser Ser His Phe Glu His 
145                 150                 155                 160 


Ile Ile Tyr Arg Met Asp Asp Val Tyr Lys Glu Pro Leu Lys Cys Gly 
                165                 170                 175     


Val Ser Asn Lys Asp Ile Glu Lys Glu Thr Ala Lys Asp Glu Glu Glu 
            180                 185                 190         


Glu Pro Pro Ser Met Thr Gln Leu Leu Arg Arg Arg Arg Ala Val Leu 
        195                 200                 205             


Pro Gln Thr Arg Tyr Val Glu Leu Phe Ile Val Val Asp Lys Glu Arg 
    210                 215                 220                 


Tyr Asp Met Met Gly Arg Asn Gln Thr Ala Val Arg Glu Glu Met Ile 
225                 230                 235                 240 


Leu Leu Ala Asn Tyr Leu Asp Ser Met Tyr Ile Met Leu Asn Ile Arg 
                245                 250                 255     


Ile Val Leu Val Gly Leu Glu Ile Trp Thr Asn Gly Asn Leu Ile Asn 
            260                 265                 270         


Ile Val Gly Gly Ala Gly Asp Val Leu Gly Asn Phe Val Gln Trp Arg 
        275                 280                 285             


Glu Lys Phe Leu Ile Thr Arg Arg Arg His Asp Ser Ala Gln Leu Val 
    290                 295                 300                 


Leu Lys Lys Gly Phe Gly Gly Thr Ala Gly Met Ala Phe Val Gly Thr 
305                 310                 315                 320 


Val Cys Ser Arg Ser His Ala Gly Gly Ile Asn Val Phe Gly Gln Ile 
                325                 330                 335     


Thr Val Glu Thr Phe Ala Ser Ile Val Ala His Glu Leu Gly His Asn 
            340                 345                 350         


Leu Gly Met Asn His Asp Asp Gly Arg Asp Cys Ser Cys Gly Ala Lys 
        355                 360                 365             


Ser Cys Ile Met Asn Ser Gly Ala Ser Gly Ser Arg Asn Phe Ser Ser 
    370                 375                 380                 


Cys Ser Ala Glu Asp Phe Glu Lys Leu Thr Leu Asn Lys Gly Gly Asn 
385                 390                 395                 400 


Cys Leu Leu Asn Ile Pro Lys Pro Asp Glu Ala Tyr Ser Ala Pro Ser 
                405                 410                 415     


Cys Gly Asn Lys Leu Val Asp Ala Gly Glu Glu Cys Asp Cys Gly Thr 
            420                 425                 430         


Pro Lys Glu Cys Glu Leu Asp Pro Cys Cys Glu Gly Ser Thr Cys Lys 
        435                 440                 445             


Leu Lys Ser Phe Ala Glu Cys Ala Tyr Gly Asp Cys Cys Lys Asp Cys 
    450                 455                 460                 


Arg Phe Leu Pro Gly Gly Thr Leu Cys Arg Gly Lys Thr Ser Glu Cys 
465                 470                 475                 480 


Asp Val Pro Glu Tyr Cys Asn Gly Ser Ser Gln Phe Cys Gln Pro Asp 
                485                 490                 495     


Val Phe Ile Gln Asn Gly Tyr Pro Cys Gln Asn Asn Lys Ala Tyr Cys 
            500                 505                 510         


Tyr Asn Gly Met Cys Gln Tyr Tyr Asp Ala Gln Cys Gln Val Ile Phe 
        515                 520                 525             


Gly Ser Lys Ala Lys Ala Ala Pro Lys Asp Cys Phe Ile Glu Val Asn 
    530                 535                 540                 


Ser Lys Gly Asp Arg Phe Gly Asn Cys Gly Phe Ser Gly Asn Glu Tyr 
545                 550                 555                 560 


Lys Lys Cys Ala Thr Gly Asn Ala Leu Cys Gly Lys Leu Gln Cys Glu 
                565                 570                 575     


Asn Val Gln Glu Ile Pro Val Phe Gly Ile Val Pro Ala Ile Ile Gln 
            580                 585                 590         


Thr Pro Ser Arg Gly Thr Lys Cys Trp Gly Val Asp Phe Gln Leu Gly 
        595                 600                 605             


Ser Asp Val Pro Asp Pro Gly Met Val Asn Glu Gly Thr Lys Cys Gly 
    610                 615                 620                 


Ala Gly Lys Ile Cys Arg Asn Phe Gln Cys Val Asp Ala Ser Val Leu 
625                 630                 635                 640 


Asn Tyr Asp Cys Asp Val Gln Lys Lys Cys His Gly His Gly Val Cys 
                645                 650                 655     


Asn Ser Asn Lys Asn Cys His Cys Glu Asn Gly Trp Ala Pro Pro Asn 
            660                 665                 670         


Cys Glu Thr Lys Gly Tyr Gly Gly Ser Val Asp Ser Gly Pro Thr Tyr 
        675                 680                 685             


Asn Gly Gln Met Ala Lys Ile Lys Gln Thr Leu Leu Asp Ser Arg Gly 
    690                 695                 700                 


Val Phe Leu Asp Met Phe Leu Gln 
705                 710         


<210>  310
<211>  147
<212>  PRT
<213>  Homo Sapiens

<400>  310

Met Gly Ser Gly Ala Arg Phe Pro Ser Gly Thr Leu Arg Val Arg Trp 
1               5                   10                  15      


Leu Leu Leu Leu Gly Leu Val Gly Pro Val Leu Gly Ala Ala Arg Pro 
            20                  25                  30          


Gly Phe Gln Gln Thr Ser His Leu Ser Ser Tyr Glu Ile Ile Thr Pro 
        35                  40                  45              


Trp Arg Leu Thr Arg Glu Arg Arg Glu Ala Pro Arg Pro Tyr Ser Lys 
    50                  55                  60                  


Gln Val Ser Tyr Val Ile Gln Ala Glu Gly Lys Glu His Ile Ile His 
65                  70                  75                  80  


Leu Glu Arg Asn Lys Asp Leu Leu Pro Glu Asp Phe Val Val Tyr Thr 
                85                  90                  95      


Tyr Asn Lys Glu Gly Thr Leu Ile Thr Asp His Pro Asn Ile Gln Arg 
            100                 105                 110         


Cys Gly Pro Leu Cys Ile Arg Glu Gln Ser Thr Pro Gly Asp Arg Ala 
        115                 120                 125             


Gly Gln Asn Thr Gln Asn Asn Trp Gln Met Ser Asn Leu Ala Phe Cys 
    130                 135                 140                 


Val Tyr Tyr 
145         


<210>  311
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  311

Met Gly Ser Gly Ala Arg Phe Pro Ser Gly Thr Leu Arg Val Arg Trp 
1               5                   10                  15      


Leu Leu Leu Leu Gly Leu Val Gly Pro Val Leu Gly Ala Ala Arg Pro 
            20                  25                  30          


Gly Phe Gln Gln Thr Ser His Leu Ser Ser Tyr Glu Ile Ile Thr Pro 
        35                  40                  45              


Trp Arg Leu Thr Arg Glu Arg Arg Glu Ala Pro Arg Pro Tyr Ser Lys 
    50                  55                  60                  


Gln Val Ser Tyr Val Ile Gln Ala Glu Gly Lys Glu His Ile Ile His 
65                  70                  75                  80  


Leu Glu Arg Asn Lys Asp Leu Leu Pro Glu Asp Phe Val Val Tyr Thr 
                85                  90                  95      


Tyr Asn Lys Glu Gly Thr Leu Ile Thr Asp His Pro Asn Ile Gln Val 
            100                 105                 110         


Met Tyr Phe Ser Leu Asp Pro Ile Ala Asn Phe Lys Thr Ile Ile Ile 
        115                 120                 125             


<210>  312
<211>  391
<212>  PRT
<213>  Homo Sapiens

<400>  312

Met Ile Leu Asn Gly Glu Glu Ile Ile Leu Ser Leu Gln Lys Thr Lys 
1               5                   10                  15      


His Leu Leu Gly Pro Asp Tyr Thr Glu Thr Leu Tyr Ser Pro Arg Gly 
            20                  25                  30          


Glu Glu Ile Thr Thr Lys Pro Glu Asn Met Glu His Cys Tyr Tyr Lys 
        35                  40                  45              


Gly Asn Ile Leu Asn Glu Lys Asn Ser Val Ala Ser Ile Ser Thr Cys 
    50                  55                  60                  


Asp Gly Leu Arg Gly Tyr Phe Thr His His His Gln Arg Tyr Gln Ile 
65                  70                  75                  80  


Lys Pro Leu Lys Ser Thr Asp Glu Lys Glu His Ala Val Phe Thr Ser 
                85                  90                  95      


Asn Gln Glu Glu Gln Asp Pro Ala Asn His Thr Cys Gly Val Lys Ser 
            100                 105                 110         


Thr Asp Gly Lys Gln Gly Pro Ile Arg Ile Ser Arg Ser Leu Lys Ser 
        115                 120                 125             


Pro Glu Lys Glu Asp Phe Leu Arg Ala Gln Lys Tyr Ile Asp Leu Tyr 
    130                 135                 140                 


Leu Val Leu Asp Asn Ala Phe Tyr Lys Asn Tyr Asn Glu Asn Leu Thr 
145                 150                 155                 160 


Leu Ile Arg Ser Phe Val Phe Asp Val Met Asn Leu Leu Asn Val Ile 
                165                 170                 175     


Tyr Asn Thr Ile Asp Val Gln Val Ala Leu Val Gly Met Glu Ile Trp 
            180                 185                 190         


Ser Asp Gly Asp Lys Ile Lys Val Val Pro Ser Ala Ser Thr Thr Phe 
        195                 200                 205             


Asp Asn Phe Leu Arg Trp His Ser Ser Asn Leu Gly Lys Lys Ile His 
    210                 215                 220                 


Asp His Ala Gln Leu Leu Ser Gly Ile Ser Phe Asn Asn Arg Arg Val 
225                 230                 235                 240 


Gly Leu Ala Ala Ser Asn Ser Leu Cys Ser Pro Ser Ser Val Ala Val 
                245                 250                 255     


Ile Glu Ala Lys Lys Lys Asn Asn Val Ala Leu Val Gly Val Met Ser 
            260                 265                 270         


His Glu Leu Gly His Val Leu Gly Met Pro Asp Val Pro Phe Asn Thr 
        275                 280                 285             


Lys Cys Pro Ser Gly Ser Cys Val Met Asn Gln Tyr Leu Ser Ser Lys 
    290                 295                 300                 


Phe Pro Lys Asp Phe Ser Thr Ser Cys Arg Ala His Phe Glu Arg Tyr 
305                 310                 315                 320 


Leu Leu Ser Gln Lys Pro Lys Cys Leu Leu Gln Ala Pro Ile Pro Thr 
                325                 330                 335     


Asn Ile Met Thr Thr Pro Val Cys Gly Asn His Leu Leu Glu Val Gly 
            340                 345                 350         


Glu Asp Cys Asp Cys Gly Ser Pro Lys Glu Cys Thr Asn Leu Cys Cys 
        355                 360                 365             


Glu Ala Leu Thr Cys Lys Leu Lys Pro Gly Thr Asp Cys Gly Gly Asp 
    370                 375                 380                 


Ala Pro Asn His Thr Thr Glu 
385                 390     


<210>  313
<211>  470
<212>  PRT
<213>  Homo Sapiens

<400>  313

Met Leu Arg Gly Ile Ser Gln Leu Pro Ala Val Ala Thr Met Ser Trp 
1               5                   10                  15      


Val Leu Leu Pro Val Leu Trp Leu Ile Val Gln Thr Gln Ala Ile Ala 
            20                  25                  30          


Ile Lys Gln Thr Pro Glu Leu Thr Leu His Glu Ile Val Cys Pro Lys 
        35                  40                  45              


Lys Leu His Ile Leu His Lys Arg Glu Ile Lys Asn Asn Gln Thr Glu 
    50                  55                  60                  


Lys His Gly Lys Glu Glu Arg Tyr Glu Pro Glu Val Gln Tyr Gln Met 
65                  70                  75                  80  


Ile Leu Asn Gly Glu Glu Ile Ile Leu Ser Leu Gln Lys Thr Lys His 
                85                  90                  95      


Leu Leu Gly Pro Asp Tyr Thr Glu Thr Leu Tyr Ser Pro Arg Gly Glu 
            100                 105                 110         


Glu Ile Thr Thr Lys Pro Glu Asn Met Glu His Cys Tyr Tyr Lys Gly 
        115                 120                 125             


Asn Ile Leu Asn Glu Lys Asn Ser Val Ala Ser Ile Ser Thr Cys Asp 
    130                 135                 140                 


Gly Leu Arg Gly Tyr Phe Thr His His His Gln Arg Tyr Gln Ile Lys 
145                 150                 155                 160 


Pro Leu Lys Ser Thr Asp Glu Lys Glu His Ala Val Phe Thr Ser Asn 
                165                 170                 175     


Gln Glu Glu Gln Asp Pro Ala Asn His Thr Cys Gly Val Lys Ser Thr 
            180                 185                 190         


Asp Gly Lys Gln Gly Pro Ile Arg Ile Ser Arg Ser Leu Lys Ser Pro 
        195                 200                 205             


Glu Lys Glu Asp Phe Leu Arg Ala Gln Lys Tyr Ile Asp Leu Tyr Leu 
    210                 215                 220                 


Val Leu Asp Asn Ala Phe Tyr Lys Asn Tyr Asn Glu Asn Leu Thr Leu 
225                 230                 235                 240 


Ile Arg Ser Phe Val Phe Asp Val Met Asn Leu Leu Asn Val Ile Tyr 
                245                 250                 255     


Asn Thr Ile Asp Val Gln Val Ala Leu Val Gly Met Glu Ile Trp Ser 
            260                 265                 270         


Asp Gly Asp Lys Ile Lys Val Val Pro Ser Ala Ser Thr Thr Phe Asp 
        275                 280                 285             


Asn Phe Leu Arg Trp His Ser Ser Asn Leu Gly Lys Lys Ile His Asp 
    290                 295                 300                 


His Ala Gln Leu Leu Ser Gly Ile Ser Phe Asn Asn Arg Arg Val Gly 
305                 310                 315                 320 


Leu Ala Ala Ser Asn Ser Leu Cys Ser Pro Ser Ser Val Ala Val Ile 
                325                 330                 335     


Glu Ala Lys Lys Lys Asn Asn Val Ala Leu Val Gly Val Met Ser His 
            340                 345                 350         


Glu Leu Gly His Val Leu Gly Met Pro Asp Val Pro Phe Asn Thr Lys 
        355                 360                 365             


Cys Pro Ser Gly Ser Cys Val Met Asn Gln Tyr Leu Ser Ser Lys Phe 
    370                 375                 380                 


Pro Lys Asp Phe Ser Thr Ser Cys Arg Ala His Phe Glu Arg Tyr Leu 
385                 390                 395                 400 


Leu Ser Gln Lys Pro Lys Cys Leu Leu Gln Ala Pro Ile Pro Thr Asn 
                405                 410                 415     


Ile Met Thr Thr Pro Val Cys Gly Asn His Leu Leu Glu Val Gly Glu 
            420                 425                 430         


Asp Cys Asp Cys Gly Ser Pro Lys Glu Cys Thr Asn Leu Cys Cys Glu 
        435                 440                 445             


Ala Leu Thr Cys Lys Leu Lys Pro Gly Thr Asp Cys Gly Gly Asp Ala 
    450                 455                 460                 


Pro Asn His Thr Thr Glu 
465                 470 


<210>  314
<211>  41
<212>  PRT
<213>  Homo Sapiens

<400>  314

Met Leu Arg Gly Ile Ser Gln Leu Pro Ala Val Ala Thr Met Ser Trp 
1               5                   10                  15      


Val Leu Leu Pro Val Leu Trp Leu Ile Val Gln Thr Gln Ala Ser Asn 
            20                  25                  30          


Cys Ala Trp Pro Lys Val Ser Ile Gln 
        35                  40      


<210>  315
<211>  171
<212>  PRT
<213>  Homo Sapiens

<400>  315

Met Leu Val Ala Asp Gln Ser Met Ala Glu Phe His Gly Ser Gly Leu 
1               5                   10                  15      


Lys His Tyr Leu Leu Thr Leu Phe Ser Val Ala Ala Arg Leu Tyr Lys 
            20                  25                  30          


His Pro Ser Ile Arg Asn Ser Val Ser Leu Val Val Val Lys Ile Leu 
        35                  40                  45              


Val Ile His Asp Glu Gln Lys Gly Pro Glu Val Thr Ser Asn Ala Ala 
    50                  55                  60                  


Leu Thr Leu Arg Asn Phe Cys Asn Trp Gln Lys Gln His Asn Pro Pro 
65                  70                  75                  80  


Ser Asp Arg Asp Ala Glu His Tyr Asp Thr Ala Ile Leu Phe Thr Arg 
                85                  90                  95      


Gln Asp Leu Cys Gly Ser Gln Thr Cys Asp Thr Leu Gly Met Ala Asp 
            100                 105                 110         


Val Gly Thr Val Cys Asp Pro Ser Arg Ser Cys Ser Val Ile Glu Asp 
        115                 120                 125             


Asp Gly Leu Gln Ala Ala Phe Thr Thr Ala His Glu Leu Gly His Val 
    130                 135                 140                 


Phe Asn Met Pro His Asp Asp Ala Lys Gln Cys Ala Ser Leu Asn Gly 
145                 150                 155                 160 


Val Asn Gln Asp Ser His Met Met Ala Ser Met 
                165                 170     


<210>  316
<211>  967
<212>  PRT
<213>  Homo Sapiens

<400>  316

Met Gln Arg Ala Val Pro Glu Gly Phe Gly Arg Arg Lys Leu Gly Ser 
1               5                   10                  15      


Asp Met Gly Asn Ala Glu Arg Ala Pro Gly Ser Arg Ser Phe Gly Pro 
            20                  25                  30          


Val Pro Thr Leu Leu Leu Leu Ala Ala Ala Leu Leu Ala Val Ser Asp 
        35                  40                  45              


Ala Leu Gly Arg Pro Ser Glu Glu Asp Glu Glu Leu Val Val Pro Glu 
    50                  55                  60                  


Leu Glu Arg Ala Pro Gly His Gly Thr Thr Arg Leu Arg Leu His Ala 
65                  70                  75                  80  


Phe Asp Gln Gln Leu Asp Leu Glu Leu Arg Pro Asp Ser Ser Phe Leu 
                85                  90                  95      


Ala Pro Gly Phe Thr Leu Gln Asn Val Gly Arg Lys Ser Gly Ser Glu 
            100                 105                 110         


Thr Pro Leu Pro Glu Thr Asp Leu Ala His Cys Phe Tyr Ser Gly Thr 
        115                 120                 125             


Val Asn Gly Asp Pro Ser Ser Ala Ala Ala Leu Ser Leu Cys Glu Gly 
    130                 135                 140                 


Val Arg Gly Ala Phe Tyr Leu Leu Gly Glu Ala Tyr Phe Ile Gln Pro 
145                 150                 155                 160 


Leu Pro Ala Ala Ser Glu Arg Leu Ala Thr Ala Ala Pro Gly Glu Lys 
                165                 170                 175     


Pro Pro Ala Pro Leu Gln Phe His Leu Leu Arg Arg Asn Arg Gln Gly 
            180                 185                 190         


Asp Val Gly Gly Thr Cys Gly Val Val Asp Asp Glu Pro Arg Pro Thr 
        195                 200                 205             


Gly Lys Ala Glu Thr Glu Asp Glu Asp Glu Gly Thr Glu Gly Glu Asp 
    210                 215                 220                 


Glu Gly Ala Gln Trp Ser Pro Gln Asp Pro Ala Leu Gln Gly Val Gly 
225                 230                 235                 240 


Gln Pro Thr Gly Thr Gly Ser Ile Arg Lys Lys Arg Phe Val Ser Ser 
                245                 250                 255     


His Arg Tyr Val Glu Thr Met Leu Val Ala Asp Gln Ser Met Ala Glu 
            260                 265                 270         


Phe His Gly Ser Gly Leu Lys His Tyr Leu Leu Thr Leu Phe Ser Val 
        275                 280                 285             


Ala Ala Arg Leu Tyr Lys His Pro Ser Ile Arg Asn Ser Val Ser Leu 
    290                 295                 300                 


Val Val Val Lys Ile Leu Val Ile His Asp Glu Gln Lys Gly Pro Glu 
305                 310                 315                 320 


Val Thr Ser Asn Ala Ala Leu Thr Leu Arg Asn Phe Cys Asn Trp Gln 
                325                 330                 335     


Lys Gln His Asn Pro Pro Ser Asp Arg Asp Ala Glu His Tyr Asp Thr 
            340                 345                 350         


Ala Ile Leu Phe Thr Arg Gln Asp Leu Cys Gly Ser Gln Thr Cys Asp 
        355                 360                 365             


Thr Leu Gly Met Ala Asp Val Gly Thr Val Cys Asp Pro Ser Arg Ser 
    370                 375                 380                 


Cys Ser Val Ile Glu Asp Asp Gly Leu Gln Ala Ala Phe Thr Thr Ala 
385                 390                 395                 400 


His Glu Leu Gly His Val Phe Asn Met Pro His Asp Asp Ala Lys Gln 
                405                 410                 415     


Cys Ala Ser Leu Asn Gly Val Asn Gln Asp Ser His Met Met Ala Ser 
            420                 425                 430         


Met Leu Ser Asn Leu Asp His Ser Gln Pro Trp Ser Pro Cys Ser Ala 
        435                 440                 445             


Tyr Met Ile Thr Ser Phe Leu Asp Asn Gly His Gly Glu Cys Leu Met 
    450                 455                 460                 


Asp Lys Pro Gln Asn Pro Ile Gln Leu Pro Gly Asp Leu Pro Gly Thr 
465                 470                 475                 480 


Ser Tyr Asp Ala Asn Arg Gln Cys Gln Phe Thr Phe Gly Glu Asp Ser 
                485                 490                 495     


Lys His Cys Pro Asp Ala Ala Ser Thr Cys Ser Thr Leu Trp Cys Thr 
            500                 505                 510         


Gly Thr Ser Gly Gly Val Leu Val Cys Gln Thr Lys His Phe Pro Trp 
        515                 520                 525             


Ala Asp Gly Thr Ser Cys Gly Glu Gly Lys Trp Cys Ile Asn Gly Lys 
    530                 535                 540                 


Cys Val Asn Lys Thr Asp Arg Lys His Phe Asp Thr Pro Phe His Gly 
545                 550                 555                 560 


Ser Trp Gly Met Trp Gly Pro Trp Gly Asp Cys Ser Arg Thr Cys Gly 
                565                 570                 575     


Gly Gly Val Gln Tyr Thr Met Arg Glu Cys Asp Asn Pro Val Pro Lys 
            580                 585                 590         


Asn Gly Gly Lys Tyr Cys Glu Gly Lys Arg Val Arg Tyr Arg Ser Cys 
        595                 600                 605             


Asn Leu Glu Asp Cys Pro Asp Asn Asn Gly Lys Thr Phe Arg Glu Glu 
    610                 615                 620                 


Gln Cys Glu Ala His Asn Glu Phe Ser Lys Ala Ser Phe Gly Ser Gly 
625                 630                 635                 640 


Pro Ala Val Glu Trp Ile Pro Lys Tyr Ala Gly Val Ser Pro Lys Asp 
                645                 650                 655     


Arg Cys Lys Leu Ile Cys Gln Ala Lys Gly Ile Gly Tyr Phe Phe Val 
            660                 665                 670         


Leu Gln Pro Lys Val Val Asp Gly Thr Pro Cys Ser Pro Asp Ser Thr 
        675                 680                 685             


Ser Val Cys Val Gln Gly Gln Cys Val Lys Ala Gly Cys Asp Arg Ile 
    690                 695                 700                 


Ile Asp Ser Lys Lys Lys Phe Asp Lys Cys Gly Val Cys Gly Gly Asn 
705                 710                 715                 720 


Gly Ser Thr Cys Lys Lys Ile Ser Gly Ser Val Thr Ser Ala Lys Pro 
                725                 730                 735     


Gly Tyr His Asp Ile Ile Thr Ile Pro Thr Gly Ala Thr Asn Ile Glu 
            740                 745                 750         


Val Lys Gln Arg Asn Gln Arg Gly Ser Arg Asn Asn Gly Ser Phe Leu 
        755                 760                 765             


Ala Ile Lys Ala Ala Asp Gly Thr Tyr Ile Leu Asn Gly Asp Tyr Thr 
    770                 775                 780                 


Leu Ser Thr Leu Glu Gln Asp Ile Met Tyr Lys Gly Val Val Leu Arg 
785                 790                 795                 800 


Tyr Ser Gly Ser Ser Ala Ala Leu Glu Arg Ile Arg Ser Phe Ser Pro 
                805                 810                 815     


Leu Lys Glu Pro Leu Thr Ile Gln Val Leu Thr Val Gly Asn Ala Leu 
            820                 825                 830         


Arg Pro Lys Ile Lys Tyr Thr Tyr Phe Val Lys Lys Lys Lys Glu Ser 
        835                 840                 845             


Phe Asn Ala Ile Pro Thr Phe Ser Ala Trp Val Ile Glu Glu Trp Gly 
    850                 855                 860                 


Glu Cys Ser Lys Ser Cys Glu Leu Gly Trp Gln Arg Arg Leu Val Glu 
865                 870                 875                 880 


Cys Arg Asp Ile Asn Gly Gln Pro Ala Ser Glu Cys Ala Lys Glu Val 
                885                 890                 895     


Lys Pro Ala Ser Thr Arg Pro Cys Ala Asp His Pro Cys Pro Gln Trp 
            900                 905                 910         


Gln Leu Gly Glu Trp Ser Ser Cys Ser Lys Thr Cys Gly Lys Gly Tyr 
        915                 920                 925             


Lys Lys Arg Ser Leu Lys Cys Leu Ser His Asp Gly Gly Val Leu Ser 
    930                 935                 940                 


His Glu Ser Cys Asp Pro Leu Lys Lys Pro Lys His Phe Ile Asp Phe 
945                 950                 955                 960 


Cys Thr Met Ala Glu Cys Ser 
                965         


<210>  317
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  317

Met Val Thr Trp Glu Gly Thr Gly Ser Ile Arg Lys Lys Arg Phe Val 
1               5                   10                  15      


Ser Ser His Arg Tyr Val Glu Thr Met Leu Val Ala Asp Gln Ser Met 
            20                  25                  30          


Ala Glu Phe His Gly Ser Gly Leu Lys His Tyr Leu Leu Thr Leu Phe 
        35                  40                  45              


Ser Val Ala Ala Arg Leu Tyr Lys His Pro Ser Ile Arg Asn Ser Val 
    50                  55                  60                  


Ser Leu Val Val Val Lys Ile Leu Val Ile His Asp Glu Gln Lys Gly 
65                  70                  75                  80  


Pro Glu Val Thr Ser Asn Ala Ala Leu Thr Leu Arg Asn Phe Cys Asn 
                85                  90                  95      


Trp Gln Lys Gln His Asn Pro Pro Ser Asp Arg Asp Ala Glu His Tyr 
            100                 105                 110         


Asp Thr Ala Ile Leu Phe Thr Arg Gln Asp Leu Cys Gly Ser Gln Thr 
        115                 120                 125             


<210>  318
<211>  200
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  318

Xaa Cys Arg Ser Phe Leu Leu Arg Pro Ser Leu Cys Ala Val Leu Ile 
1               5                   10                  15      


Leu Gln Phe Phe Leu Phe His His Phe Gly Thr Gly Ser Ile Arg Lys 
            20                  25                  30          


Lys Arg Phe Val Ser Ser His Arg Tyr Val Glu Thr Met Leu Val Ala 
        35                  40                  45              


Asp Gln Ser Met Ala Glu Phe His Gly Ser Gly Leu Lys His Tyr Leu 
    50                  55                  60                  


Leu Thr Leu Phe Ser Val Ala Ala Arg Leu Tyr Lys His Pro Ser Ile 
65                  70                  75                  80  


Arg Asn Ser Val Ser Leu Val Val Val Lys Ile Leu Val Ile His Asp 
                85                  90                  95      


Glu Gln Lys Gly Pro Glu Val Thr Ser Asn Ala Ala Leu Thr Leu Arg 
            100                 105                 110         


Asn Phe Cys Asn Trp Gln Lys Gln His Asn Pro Pro Ser Asp Arg Asp 
        115                 120                 125             


Ala Glu His Tyr Asp Thr Ala Ile Leu Phe Thr Arg Gln Asp Leu Cys 
    130                 135                 140                 


Gly Ser Gln Thr Cys Asp Thr Leu Gly Met Ala Asp Val Gly Thr Val 
145                 150                 155                 160 


Cys Asp Pro Ser Arg Ser Cys Ser Val Ile Glu Asp Asp Gly Leu Gln 
                165                 170                 175     


Ala Ala Phe Thr Thr Ala His Glu Leu Gly His Val Phe Asn Met Pro 
            180                 185                 190         


His Asp Asp Ala Lys Gln Cys Ala 
        195                 200 


<210>  319
<211>  1103
<212>  PRT
<213>  Homo Sapiens

<400>  319

Met Ala Pro Ala Cys Gln Ile Leu Arg Trp Ala Leu Ala Leu Gly Leu 
1               5                   10                  15      


Gly Leu Met Phe Glu Val Thr His Ala Phe Arg Ser Gln Asp Glu Phe 
            20                  25                  30          


Leu Ser Ser Leu Glu Ser Tyr Glu Ile Ala Phe Pro Thr Arg Val Asp 
        35                  40                  45              


His Asn Gly Ala Leu Leu Ala Phe Ser Pro Pro Pro Pro Arg Arg Gln 
    50                  55                  60                  


Arg Arg Gly Thr Gly Ala Thr Ala Glu Ser Arg Leu Phe Tyr Lys Val 
65                  70                  75                  80  


Ala Ser Pro Ser Thr His Phe Leu Leu Asn Leu Thr Arg Ser Ser Arg 
                85                  90                  95      


Leu Leu Ala Gly His Val Ser Val Glu Tyr Trp Thr Arg Glu Gly Leu 
            100                 105                 110         


Ala Trp Gln Arg Ala Ala Arg Pro His Cys Leu Tyr Ala Gly His Leu 
        115                 120                 125             


Gln Gly Gln Ala Ser Ser Ser His Val Ala Ile Ser Thr Cys Gly Gly 
    130                 135                 140                 


Leu His Gly Leu Ile Val Ala Asp Glu Glu Glu Tyr Leu Ile Glu Pro 
145                 150                 155                 160 


Leu His Gly Gly Pro Lys Gly Ser Arg Ser Pro Glu Glu Ser Gly Pro 
                165                 170                 175     


His Val Val Tyr Lys Arg Ser Ser Leu Arg His Pro His Leu Asp Thr 
            180                 185                 190         


Ala Cys Gly Val Arg Asp Glu Lys Pro Trp Lys Gly Arg Pro Trp Trp 
        195                 200                 205             


Leu Arg Thr Leu Lys Pro Pro Pro Ala Arg Pro Leu Gly Asn Glu Thr 
    210                 215                 220                 


Glu Arg Gly Gln Pro Gly Leu Lys Arg Ser Val Ser Arg Glu Arg Tyr 
225                 230                 235                 240 


Val Glu Thr Leu Val Val Ala Asp Lys Met Met Val Ala Tyr His Gly 
                245                 250                 255     


Arg Arg Asp Val Glu Gln Tyr Val Leu Ala Ile Met Asn Ile Val Ala 
            260                 265                 270         


Lys Leu Phe Gln Asp Ser Ser Leu Gly Ser Thr Val Asn Ile Leu Val 
        275                 280                 285             


Thr Arg Leu Ile Leu Leu Thr Glu Asp Gln Pro Thr Leu Glu Ile Thr 
    290                 295                 300                 


His His Ala Gly Lys Ser Leu Asp Ser Phe Cys Lys Trp Gln Lys Ser 
305                 310                 315                 320 


Ile Val Asn His Ser Gly His Gly Asn Ala Ile Pro Glu Asn Gly Val 
                325                 330                 335     


Ala Asn His Asp Thr Ala Val Leu Ile Thr Arg Tyr Asp Ile Cys Ile 
            340                 345                 350         


Tyr Lys Asn Lys Pro Cys Gly Thr Leu Gly Leu Ala Pro Val Gly Gly 
        355                 360                 365             


Met Cys Glu Arg Glu Arg Ser Cys Ser Val Asn Glu Asp Ile Gly Leu 
    370                 375                 380                 


Ala Thr Ala Phe Thr Ile Ala His Glu Ile Gly His Thr Phe Gly Met 
385                 390                 395                 400 


Asn His Asp Gly Val Gly Asn Ser Cys Gly Ala Arg Gly Gln Asp Pro 
                405                 410                 415     


Ala Lys Leu Met Ala Ala His Ile Thr Met Lys Thr Asn Pro Phe Val 
            420                 425                 430         


Trp Ser Ser Cys Ser Arg Asp Tyr Ile Thr Ser Phe Leu Asp Ser Gly 
        435                 440                 445             


Leu Gly Leu Cys Leu Asn Asn Arg Pro Pro Arg Gln Asp Phe Val Tyr 
    450                 455                 460                 


Pro Thr Val Ala Pro Gly Gln Ala Tyr Asp Ala Asp Glu Gln Cys Arg 
465                 470                 475                 480 


Phe Gln His Gly Val Lys Ser Arg Gln Cys Lys Tyr Gly Glu Val Cys 
                485                 490                 495     


Ser Glu Leu Trp Cys Leu Ser Lys Ser Asn Arg Cys Ile Thr Asn Ser 
            500                 505                 510         


Ile Pro Ala Ala Glu Gly Thr Leu Cys Gln Thr His Thr Ile Asp Lys 
        515                 520                 525             


Gly Trp Cys Tyr Lys Arg Val Cys Val Pro Phe Gly Ser Arg Pro Glu 
    530                 535                 540                 


Gly Val Asp Gly Ala Trp Gly Pro Trp Thr Pro Trp Gly Asp Cys Ser 
545                 550                 555                 560 


Arg Thr Cys Gly Gly Gly Val Ser Ser Ser Ser Arg His Cys Asp Ser 
                565                 570                 575     


Pro Arg Pro Thr Ile Gly Gly Lys Tyr Cys Leu Gly Glu Arg Arg Arg 
            580                 585                 590         


His Arg Ser Cys Asn Thr Asp Asp Cys Pro Pro Gly Ser Gln Asp Phe 
        595                 600                 605             


Arg Glu Val Gln Cys Ser Glu Phe Asp Ser Ile Pro Phe Arg Gly Lys 
    610                 615                 620                 


Phe Tyr Lys Trp Lys Thr Tyr Arg Gly Gly Gly Val Lys Ala Cys Ser 
625                 630                 635                 640 


Leu Thr Cys Leu Ala Glu Gly Phe Asn Phe Tyr Thr Glu Arg Ala Ala 
                645                 650                 655     


Ala Val Val Asp Gly Thr Pro Cys Arg Pro Asp Thr Val Asp Ile Cys 
            660                 665                 670         


Val Ser Gly Glu Cys Lys His Val Gly Cys Asp Arg Val Leu Gly Ser 
        675                 680                 685             


Asp Leu Arg Glu Asp Lys Cys Arg Val Cys Gly Gly Asp Gly Ser Ala 
    690                 695                 700                 


Cys Glu Thr Ile Glu Gly Val Phe Ser Pro Ala Ser Pro Gly Ala Gly 
705                 710                 715                 720 


Tyr Glu Asp Val Val Trp Ile Pro Lys Gly Ser Val His Ile Phe Ile 
                725                 730                 735     


Gln Asp Leu Asn Leu Ser Leu Ser His Leu Ala Leu Lys Gly Asp Gln 
            740                 745                 750         


Glu Ser Leu Leu Leu Glu Gly Leu Pro Gly Thr Pro Gln Pro His Arg 
        755                 760                 765             


Leu Pro Leu Ala Gly Thr Thr Phe Gln Leu Arg Gln Gly Pro Asp Gln 
    770                 775                 780                 


Val Gln Ser Leu Glu Ala Leu Gly Pro Ile Asn Ala Ser Leu Ile Val 
785                 790                 795                 800 


Met Val Leu Ala Arg Thr Glu Leu Pro Ala Leu Arg Tyr Arg Phe Asn 
                805                 810                 815     


Ala Pro Ile Ala Arg Asp Ser Leu Pro Pro Tyr Ser Trp His Tyr Ala 
            820                 825                 830         


Pro Trp Thr Lys Cys Ser Ala Gln Cys Ala Gly Gly Ser Gln Val Gln 
        835                 840                 845             


Ala Val Glu Cys Arg Asn Gln Leu Asp Ser Ser Ala Val Ala Pro His 
    850                 855                 860                 


Tyr Cys Ser Ala His Ser Lys Leu Pro Lys Arg Gln Arg Ala Cys Asn 
865                 870                 875                 880 


Thr Glu Pro Cys Pro Pro Asp Trp Val Val Gly Asn Trp Ser Leu Cys 
                885                 890                 895     


Ser Arg Ser Cys Asp Ala Gly Val Arg Ser Arg Ser Val Val Cys Gln 
            900                 905                 910         


Arg Arg Val Ser Ala Ala Glu Glu Lys Ala Leu Asp Asp Ser Ala Cys 
        915                 920                 925             


Pro Gln Pro Arg Pro Pro Val Leu Glu Ala Cys His Gly Pro Thr Cys 
    930                 935                 940                 


Pro Pro Glu Trp Ala Ala Leu Asp Trp Ser Glu Cys Thr Pro Ser Cys 
945                 950                 955                 960 


Gly Pro Gly Leu Arg His Arg Val Val Leu Cys Lys Ser Ala Asp His 
                965                 970                 975     


Arg Ala Thr Leu Pro Pro Ala His Cys Ser Pro Ala Ala Lys Pro Pro 
            980                 985                 990         


Ala Thr Met Arg Cys Asn Leu Arg  Arg Cys Pro Pro Ala  Arg Trp Val 
        995                 1000                 1005             


Ala Gly  Glu Trp Gly Glu Cys  Ser Ala Gln Cys Gly  Val Gly Gln 
    1010                 1015                 1020             


Arg Gln  Arg Ser Val Arg Cys  Thr Ser His Thr Gly  Gln Ala Ser 
    1025                 1030                 1035             


His Glu  Cys Thr Glu Ala Leu  Arg Pro Pro Thr Thr  Gln Gln Cys 
    1040                 1045                 1050             


Glu Ala  Lys Cys Asp Ser Pro  Thr Pro Gly Asp Gly  Pro Glu Glu 
    1055                 1060                 1065             


Cys Lys  Asp Val Asn Lys Val  Ala Tyr Cys Pro Leu  Val Leu Lys 
    1070                 1075                 1080             


Phe Gln  Phe Cys Ser Arg Ala  Tyr Phe Arg Gln Met  Cys Cys Lys 
    1085                 1090                 1095             


Thr Cys  His Gly His 
    1100             


<210>  320
<211>  289
<212>  PRT
<213>  Homo Sapiens

<400>  320

Met Ala Pro Ala Cys Gln Ile Leu Arg Trp Ala Leu Ala Leu Gly Leu 
1               5                   10                  15      


Gly Leu Met Phe Glu Val Thr His Ala Phe Arg Ser Gln Asp Glu Phe 
            20                  25                  30          


Leu Ser Ser Leu Glu Ser Tyr Glu Ile Ala Phe Pro Thr Arg Val Asp 
        35                  40                  45              


His Asn Gly Ala Leu Leu Ala Phe Ser Pro Pro Pro Pro Arg Arg Gln 
    50                  55                  60                  


Arg Arg Gly Thr Gly Ala Thr Ala Glu Ser Arg Leu Phe Tyr Lys Val 
65                  70                  75                  80  


Ala Ser Pro Ser Thr His Phe Leu Leu Asn Leu Thr Arg Ser Ser Arg 
                85                  90                  95      


Leu Leu Ala Gly His Val Ser Val Glu Tyr Trp Thr Arg Glu Gly Leu 
            100                 105                 110         


Ala Trp Gln Arg Ala Ala Arg Pro His Cys Leu Tyr Ala Gly His Leu 
        115                 120                 125             


Gln Gly Gln Ala Ser Ser Ser His Val Ala Ile Ser Thr Cys Gly Gly 
    130                 135                 140                 


Leu His Gly Leu Ile Val Ala Asp Glu Glu Glu Tyr Leu Ile Glu Pro 
145                 150                 155                 160 


Leu His Gly Gly Pro Lys Gly Ser Arg Ser Pro Glu Glu Ser Gly Pro 
                165                 170                 175     


His Val Val Tyr Lys Arg Ser Ser Leu Arg His Pro His Leu Asp Thr 
            180                 185                 190         


Ala Cys Gly Val Arg Asp Glu Lys Pro Trp Lys Gly Arg Pro Trp Trp 
        195                 200                 205             


Leu Arg Thr Leu Lys Pro Pro Pro Ala Arg Pro Leu Gly Asn Glu Thr 
    210                 215                 220                 


Glu Arg Gly Gln Pro Gly Leu Lys Arg Ser Val Ser Arg Glu Arg Tyr 
225                 230                 235                 240 


Val Glu Thr Leu Val Val Ala Asp Lys Met Met Val Ala Tyr His Gly 
                245                 250                 255     


Arg Arg Asp Val Glu Gln Tyr Val Leu Ala Ile Met Asn Ile Val Arg 
            260                 265                 270         


Leu Pro Asn Phe Ser Arg Thr Arg Val Trp Glu Ala Pro Leu Thr Ser 
        275                 280                 285             


Ser 
    


<210>  321
<211>  289
<212>  PRT
<213>  Homo Sapiens

<400>  321

Met Ala Pro Ala Cys Gln Ile Leu Arg Trp Ala Leu Ala Leu Gly Leu 
1               5                   10                  15      


Gly Leu Met Phe Glu Val Thr His Ala Phe Arg Ser Gln Asp Glu Phe 
            20                  25                  30          


Leu Ser Ser Leu Glu Ser Tyr Glu Ile Ala Phe Pro Thr Arg Val Asp 
        35                  40                  45              


His Asn Gly Ala Leu Leu Ala Phe Ser Pro Pro Pro Pro Arg Arg Gln 
    50                  55                  60                  


Arg Arg Gly Thr Gly Ala Thr Ala Glu Ser Arg Leu Phe Tyr Lys Val 
65                  70                  75                  80  


Ala Ser Pro Ser Thr His Phe Leu Leu Asn Leu Thr Arg Ser Ser Arg 
                85                  90                  95      


Leu Leu Ala Gly His Val Ser Val Glu Tyr Trp Thr Arg Glu Gly Leu 
            100                 105                 110         


Ala Trp Gln Arg Ala Ala Arg Pro His Cys Leu Tyr Ala Gly His Leu 
        115                 120                 125             


Gln Gly Gln Ala Ser Ser Ser His Val Ala Ile Ser Thr Cys Gly Gly 
    130                 135                 140                 


Leu His Gly Leu Ile Val Ala Asp Glu Glu Glu Tyr Leu Ile Glu Pro 
145                 150                 155                 160 


Leu His Gly Gly Pro Lys Gly Ser Arg Ser Pro Glu Glu Ser Gly Pro 
                165                 170                 175     


His Val Val Tyr Lys Arg Ser Ser Leu Arg His Pro His Leu Asp Thr 
            180                 185                 190         


Ala Cys Gly Val Arg Asp Glu Lys Pro Trp Lys Gly Arg Pro Trp Trp 
        195                 200                 205             


Leu Arg Thr Leu Lys Pro Pro Pro Ala Arg Pro Leu Gly Asn Glu Thr 
    210                 215                 220                 


Glu Arg Gly Gln Pro Gly Leu Lys Arg Ser Val Ser Arg Glu Arg Tyr 
225                 230                 235                 240 


Val Glu Thr Leu Val Val Ala Asp Lys Met Met Val Ala Tyr His Gly 
                245                 250                 255     


Arg Arg Asp Val Glu Gln Tyr Val Leu Ala Ile Met Asn Ile Val Arg 
            260                 265                 270         


Leu Pro Asn Phe Ser Arg Thr Arg Val Trp Glu Ala Pro Leu Thr Ser 
        275                 280                 285             


Ser 
    


<210>  322
<211>  1103
<212>  PRT
<213>  Homo Sapiens

<400>  322

Met Ala Pro Ala Cys Gln Ile Leu Arg Trp Ala Leu Ala Leu Gly Leu 
1               5                   10                  15      


Gly Leu Met Phe Glu Val Thr His Ala Phe Arg Ser Gln Asp Glu Phe 
            20                  25                  30          


Leu Ser Ser Leu Glu Ser Tyr Glu Ile Ala Phe Pro Thr Arg Val Asp 
        35                  40                  45              


His Asn Gly Ala Leu Leu Ala Phe Ser Pro Pro Pro Pro Arg Arg Gln 
    50                  55                  60                  


Arg Arg Gly Thr Gly Ala Thr Ala Glu Ser Arg Leu Phe Tyr Lys Val 
65                  70                  75                  80  


Ala Ser Pro Ser Thr His Phe Leu Leu Asn Leu Thr Arg Ser Ser Arg 
                85                  90                  95      


Leu Leu Ala Gly His Val Ser Val Glu Tyr Trp Thr Arg Glu Gly Leu 
            100                 105                 110         


Ala Trp Gln Arg Ala Ala Arg Pro His Cys Leu Tyr Ala Gly His Leu 
        115                 120                 125             


Gln Gly Gln Ala Ser Ser Ser His Val Ala Ile Ser Thr Cys Gly Gly 
    130                 135                 140                 


Leu His Gly Leu Ile Val Ala Asp Glu Glu Glu Tyr Leu Ile Glu Pro 
145                 150                 155                 160 


Leu His Gly Gly Pro Lys Gly Ser Arg Ser Pro Glu Glu Ser Gly Pro 
                165                 170                 175     


His Val Val Tyr Lys Arg Ser Ser Leu Arg His Pro His Leu Asp Thr 
            180                 185                 190         


Ala Cys Gly Val Arg Asp Glu Lys Pro Trp Lys Gly Arg Pro Trp Trp 
        195                 200                 205             


Leu Arg Thr Leu Lys Pro Pro Pro Ala Arg Pro Leu Gly Asn Glu Thr 
    210                 215                 220                 


Glu Arg Gly Gln Pro Gly Leu Lys Arg Ser Val Ser Arg Glu Arg Tyr 
225                 230                 235                 240 


Val Glu Thr Leu Val Val Ala Asp Lys Met Met Val Ala Tyr His Gly 
                245                 250                 255     


Arg Arg Asp Val Glu Gln Tyr Val Leu Ala Ile Met Asn Ile Val Ala 
            260                 265                 270         


Lys Leu Phe Gln Asp Ser Ser Leu Gly Ser Thr Val Asn Ile Leu Val 
        275                 280                 285             


Thr Arg Leu Ile Leu Leu Thr Glu Asp Gln Pro Thr Leu Glu Ile Thr 
    290                 295                 300                 


His His Ala Gly Lys Ser Leu Asp Ser Phe Cys Lys Trp Gln Lys Ser 
305                 310                 315                 320 


Ile Val Asn His Ser Gly His Gly Asn Ala Ile Pro Glu Asn Gly Val 
                325                 330                 335     


Ala Asn His Asp Thr Ala Val Leu Ile Thr Arg Tyr Asp Ile Cys Ile 
            340                 345                 350         


Tyr Lys Asn Lys Pro Cys Gly Thr Leu Gly Leu Ala Pro Val Gly Gly 
        355                 360                 365             


Met Cys Glu Arg Glu Arg Ser Cys Ser Val Asn Glu Asp Ile Gly Leu 
    370                 375                 380                 


Ala Thr Ala Phe Thr Ile Ala His Glu Ile Gly His Thr Phe Gly Met 
385                 390                 395                 400 


Asn His Asp Gly Val Gly Asn Ser Cys Gly Ala Arg Gly Gln Asp Pro 
                405                 410                 415     


Ala Lys Leu Met Ala Ala His Ile Thr Met Lys Thr Asn Pro Phe Val 
            420                 425                 430         


Trp Ser Ser Cys Ser Arg Asp Tyr Ile Thr Ser Phe Leu Asp Ser Gly 
        435                 440                 445             


Leu Gly Leu Cys Leu Asn Asn Arg Pro Pro Arg Gln Asp Phe Val Tyr 
    450                 455                 460                 


Pro Thr Val Ala Pro Gly Gln Ala Tyr Asp Ala Asp Glu Gln Cys Arg 
465                 470                 475                 480 


Phe Gln His Gly Val Lys Ser Arg Gln Cys Lys Tyr Gly Glu Val Cys 
                485                 490                 495     


Ser Glu Leu Trp Cys Leu Ser Lys Ser Asn Arg Cys Ile Thr Asn Ser 
            500                 505                 510         


Ile Pro Ala Ala Glu Gly Thr Leu Cys Gln Thr His Thr Ile Asp Lys 
        515                 520                 525             


Gly Trp Cys Tyr Lys Arg Val Cys Val Pro Phe Gly Ser Arg Pro Glu 
    530                 535                 540                 


Gly Val Asp Gly Ala Trp Gly Pro Trp Thr Pro Trp Gly Asp Cys Ser 
545                 550                 555                 560 


Arg Thr Cys Gly Gly Gly Val Ser Ser Ser Ser Arg His Cys Asp Ser 
                565                 570                 575     


Pro Arg Pro Thr Ile Gly Gly Lys Tyr Cys Leu Gly Glu Arg Arg Arg 
            580                 585                 590         


His Arg Ser Cys Asn Thr Asp Asp Cys Pro Pro Gly Ser Gln Asp Phe 
        595                 600                 605             


Arg Glu Val Gln Cys Ser Glu Phe Asp Ser Ile Pro Phe Arg Gly Lys 
    610                 615                 620                 


Phe Tyr Lys Trp Lys Thr Tyr Arg Gly Gly Gly Val Lys Ala Cys Ser 
625                 630                 635                 640 


Leu Thr Cys Leu Ala Glu Gly Phe Asn Phe Tyr Thr Glu Arg Ala Ala 
                645                 650                 655     


Ala Val Val Asp Gly Thr Pro Cys Arg Pro Asp Thr Val Asp Ile Cys 
            660                 665                 670         


Val Ser Gly Glu Cys Lys His Val Gly Cys Asp Arg Val Leu Gly Ser 
        675                 680                 685             


Asp Leu Arg Glu Asp Lys Cys Arg Val Cys Gly Gly Asp Gly Ser Ala 
    690                 695                 700                 


Cys Glu Thr Ile Glu Gly Val Phe Ser Pro Ala Ser Pro Gly Ala Gly 
705                 710                 715                 720 


Tyr Glu Asp Val Val Trp Ile Pro Lys Gly Ser Val His Ile Phe Ile 
                725                 730                 735     


Gln Asp Leu Asn Leu Ser Leu Ser His Leu Ala Leu Lys Gly Asp Gln 
            740                 745                 750         


Glu Ser Leu Leu Leu Glu Gly Leu Pro Gly Thr Pro Gln Pro His Arg 
        755                 760                 765             


Leu Pro Leu Ala Gly Thr Thr Phe Gln Leu Arg Gln Gly Pro Asp Gln 
    770                 775                 780                 


Val Gln Ser Leu Glu Ala Leu Gly Pro Ile Asn Ala Ser Leu Ile Val 
785                 790                 795                 800 


Met Val Leu Ala Arg Thr Glu Leu Pro Ala Leu Arg Tyr Arg Phe Asn 
                805                 810                 815     


Ala Pro Ile Ala Arg Asp Ser Leu Pro Pro Tyr Ser Trp His Tyr Ala 
            820                 825                 830         


Pro Trp Thr Lys Cys Ser Ala Gln Cys Ala Gly Gly Ser Gln Val Gln 
        835                 840                 845             


Ala Val Glu Cys Arg Asn Gln Leu Asp Ser Ser Ala Val Ala Pro His 
    850                 855                 860                 


Tyr Cys Ser Ala His Ser Lys Leu Pro Lys Arg Gln Arg Ala Cys Asn 
865                 870                 875                 880 


Thr Glu Pro Cys Pro Pro Asp Trp Val Val Gly Asn Trp Ser Leu Cys 
                885                 890                 895     


Ser Arg Ser Cys Asp Ala Gly Val Arg Ser Arg Ser Val Val Cys Gln 
            900                 905                 910         


Arg Arg Val Ser Ala Ala Glu Glu Lys Ala Leu Asp Asp Ser Ala Cys 
        915                 920                 925             


Pro Gln Pro Arg Pro Pro Val Leu Glu Ala Cys His Gly Pro Thr Cys 
    930                 935                 940                 


Pro Pro Glu Trp Ala Ala Leu Asp Trp Ser Glu Cys Thr Pro Ser Cys 
945                 950                 955                 960 


Gly Pro Gly Leu Arg His Arg Val Val Leu Cys Lys Ser Ala Asp His 
                965                 970                 975     


Arg Ala Thr Leu Pro Pro Ala His Cys Ser Pro Ala Ala Lys Pro Pro 
            980                 985                 990         


Ala Thr Met Arg Cys Asn Leu Arg  Arg Cys Pro Pro Ala  Arg Trp Val 
        995                 1000                 1005             


Ala Gly  Glu Trp Gly Glu Cys  Ser Ala Gln Cys Gly  Val Gly Gln 
    1010                 1015                 1020             


Arg Gln  Arg Ser Val Arg Cys  Thr Ser His Thr Gly  Gln Ala Ser 
    1025                 1030                 1035             


His Glu  Cys Thr Glu Ala Leu  Arg Pro Pro Thr Thr  Gln Gln Cys 
    1040                 1045                 1050             


Glu Ala  Lys Cys Asp Ser Pro  Thr Pro Gly Asp Gly  Pro Glu Glu 
    1055                 1060                 1065             


Cys Lys  Asp Val Asn Lys Val  Ala Tyr Cys Pro Leu  Val Leu Lys 
    1070                 1075                 1080             


Phe Gln  Phe Cys Ser Arg Ala  Tyr Phe Arg Gln Met  Cys Cys Lys 
    1085                 1090                 1095             


Thr Cys  His Gly His 
    1100             


<210>  323
<211>  590
<212>  PRT
<213>  Homo Sapiens

<400>  323

Met Gly Pro Thr Ser Val Leu Arg Ala Gly Leu Thr Pro Ser Cys Leu 
1               5                   10                  15      


Pro Pro Pro Ser Gly Ala Thr Asn Gly Ser Val Ser Pro Leu Gly Arg 
            20                  25                  30          


Ala Gln Arg Val Trp Thr Glu Pro Gly Gly Arg Gly Leu His Gly Ala 
        35                  40                  45              


Thr Ala Ala Gly Pro Val Ala Ala Ala Cys Pro Leu Leu Ala Val Thr 
    50                  55                  60                  


Ala Thr Ala Pro Gly Gln Pro Ser Gly Ala Ser Thr Val Trp Val Arg 
65                  70                  75                  80  


Glu Gly Gly Thr Ala Pro Ala Thr Arg Met Thr Val Pro Leu Ala Pro 
                85                  90                  95      


Arg Thr Ser Glu Lys Cys Ser Val Leu Asn Leu Thr Ala Ser Leu Ser 
            100                 105                 110         


Val Gly Asn Ser Thr Ser Gly Lys Arg Thr Gly Glu Ala Cys Ser Leu 
        115                 120                 125             


Thr Cys Leu Ala Glu Gly Phe Asn Phe Tyr Thr Glu Arg Ala Ala Ala 
    130                 135                 140                 


Val Val Asp Gly Thr Pro Cys Arg Pro Asp Thr Val Asp Ile Cys Val 
145                 150                 155                 160 


Ser Gly Glu Cys Lys His Val Gly Cys Asp Arg Val Leu Gly Ser Asp 
                165                 170                 175     


Leu Arg Glu Asp Lys Cys Arg Val Cys Gly Gly Asp Gly Ser Ala Cys 
            180                 185                 190         


Glu Thr Ile Glu Gly Val Phe Ser Pro Ala Ser Pro Gly Ala Gly Tyr 
        195                 200                 205             


Glu Asp Val Val Trp Ile Pro Lys Gly Ser Val His Ile Phe Ile Gln 
    210                 215                 220                 


Asp Leu Asn Leu Ser Leu Ser His Leu Ala Leu Lys Gly Asp Gln Glu 
225                 230                 235                 240 


Ser Leu Leu Leu Glu Gly Leu Pro Gly Thr Pro Gln Pro His Arg Leu 
                245                 250                 255     


Pro Leu Ala Gly Thr Thr Phe Gln Leu Arg Gln Gly Pro Asp Gln Val 
            260                 265                 270         


Gln Ser Leu Glu Ala Leu Gly Pro Ile Asn Ala Ser Leu Ile Val Met 
        275                 280                 285             


Val Leu Ala Arg Thr Glu Leu Pro Ala Leu Arg Tyr Arg Phe Asn Ala 
    290                 295                 300                 


Pro Ile Ala Arg Asp Ser Leu Pro Pro Tyr Ser Trp His Tyr Ala Pro 
305                 310                 315                 320 


Trp Thr Lys Cys Ser Ala Gln Cys Ala Gly Gly Ser Gln Val Gln Ala 
                325                 330                 335     


Val Glu Cys Arg Asn Gln Leu Asp Ser Ser Ala Val Ala Pro His Tyr 
            340                 345                 350         


Cys Ser Ala His Ser Lys Leu Pro Lys Arg Gln Arg Ala Cys Asn Thr 
        355                 360                 365             


Glu Pro Cys Pro Pro Asp Trp Val Val Gly Asn Trp Ser Leu Cys Ser 
    370                 375                 380                 


Arg Ser Cys Asp Ala Gly Val Arg Ser Arg Ser Val Val Cys Gln Arg 
385                 390                 395                 400 


Arg Val Ser Ala Ala Glu Glu Lys Ala Leu Asp Asp Ser Ala Cys Pro 
                405                 410                 415     


Gln Pro Arg Pro Pro Val Leu Glu Ala Cys His Gly Pro Thr Cys Pro 
            420                 425                 430         


Pro Glu Trp Ala Ala Leu Asp Trp Ser Glu Cys Thr Pro Ser Cys Gly 
        435                 440                 445             


Pro Gly Leu Arg His Arg Val Val Leu Cys Lys Ser Ala Asp His Arg 
    450                 455                 460                 


Ala Thr Leu Pro Pro Ala His Cys Ser Pro Ala Ala Lys Pro Pro Ala 
465                 470                 475                 480 


Thr Met Arg Cys Asn Leu Arg Arg Cys Pro Pro Ala Arg Trp Val Ala 
                485                 490                 495     


Gly Glu Trp Gly Glu Cys Ser Ala Gln Cys Gly Val Gly Gln Arg Gln 
            500                 505                 510         


Arg Ser Val Arg Cys Thr Ser His Thr Gly Gln Ala Ser His Glu Cys 
        515                 520                 525             


Thr Glu Ala Leu Arg Pro Pro Thr Thr Gln Gln Cys Glu Ala Lys Cys 
    530                 535                 540                 


Asp Ser Pro Thr Pro Gly Asp Gly Pro Glu Glu Cys Lys Asp Val Asn 
545                 550                 555                 560 


Lys Val Ala Tyr Cys Pro Leu Val Leu Lys Phe Gln Phe Cys Ser Arg 
                565                 570                 575     


Ala Tyr Phe Arg Gln Met Cys Cys Lys Thr Cys His Gly His 
            580                 585                 590 


<210>  324
<211>  126
<212>  PRT
<213>  Homo Sapiens

<400>  324

Met Gly Pro Thr Ser Val Leu Arg Ala Gly Leu Thr Pro Ser Cys Leu 
1               5                   10                  15      


Pro Pro Pro Ser Gly Ala Thr Asn Gly Ser Val Ser Pro Leu Gly Arg 
            20                  25                  30          


Ala Gln Arg Val Trp Thr Glu Pro Gly Gly Arg Gly Leu His Gly Ala 
        35                  40                  45              


Thr Ala Ala Gly Pro Val Ala Ala Ala Cys Pro Leu Leu Ala Val Thr 
    50                  55                  60                  


Ala Thr Ala Pro Gly Gln Pro Ser Gly Ala Ser Thr Val Trp Val Arg 
65                  70                  75                  80  


Glu Gly Gly Thr Ala Pro Ala Thr Arg Met Thr Val Pro Leu Ala Pro 
                85                  90                  95      


Arg Thr Ser Glu Lys Cys Ser Val Leu Asn Leu Thr Ala Ser Leu Ser 
            100                 105                 110         


Val Gly Asn Ser Thr Ser Gly Lys Arg Thr Gly Glu Gly Ala 
        115                 120                 125     


<210>  325
<211>  1509
<212>  PRT
<213>  Homo Sapiens

<400>  325

Met Pro Cys Ala Gln Arg Ser Trp Leu Ala Asn Leu Ser Val Val Ala 
1               5                   10                  15      


Gln Leu Leu Asn Phe Gly Ala Leu Cys Tyr Gly Arg Gln Pro Gln Pro 
            20                  25                  30          


Gly Pro Val Arg Phe Pro Asp Arg Arg Gln Glu His Phe Ile Lys Gly 
        35                  40                  45              


Leu Pro Glu Tyr His Val Val Gly Pro Val Arg Val Asp Ala Ser Gly 
    50                  55                  60                  


His Phe Leu Ser Tyr Gly Leu His Tyr Pro Ile Thr Ser Ser Arg Arg 
65                  70                  75                  80  


Lys Arg Asp Leu Asp Gly Ser Glu Asp Trp Val Tyr Tyr Arg Ile Ser 
                85                  90                  95      


His Glu Glu Lys Asp Leu Phe Phe Asn Leu Thr Val Asn Gln Gly Phe 
            100                 105                 110         


Leu Ser Asn Ser Tyr Ile Met Glu Lys Arg Tyr Gly Asn Leu Ser His 
        115                 120                 125             


Val Lys Met Met Ala Ser Ser Ala Pro Leu Cys His Leu Ser Gly Thr 
    130                 135                 140                 


Val Leu Gln Gln Gly Thr Arg Val Gly Thr Ala Ala Leu Ser Ala Cys 
145                 150                 155                 160 


His Gly Leu Thr Gly Phe Phe Gln Leu Pro His Gly Asp Phe Phe Ile 
                165                 170                 175     


Glu Pro Val Lys Lys His Pro Leu Val Glu Gly Gly Tyr His Pro His 
            180                 185                 190         


Ile Val Tyr Arg Arg Gln Lys Val Pro Glu Thr Lys Glu Pro Thr Cys 
        195                 200                 205             


Gly Leu Lys Asp Ser Val Asn Ile Ser Gln Lys Gln Glu Leu Trp Arg 
    210                 215                 220                 


Glu Lys Trp Glu Arg His Asn Leu Pro Ser Arg Ser Leu Ser Arg Arg 
225                 230                 235                 240 


Ser Ile Ser Lys Glu Arg Trp Val Glu Thr Leu Val Val Ala Asp Thr 
                245                 250                 255     


Lys Met Ile Glu Tyr His Gly Ser Glu Asn Val Glu Ser Tyr Ile Leu 
            260                 265                 270         


Thr Ile Met Asn Met Val Thr Gly Leu Phe His Asn Pro Ser Ile Gly 
        275                 280                 285             


Asn Ala Ile His Ile Val Val Val Arg Leu Ile Leu Leu Glu Glu Glu 
    290                 295                 300                 


Glu Gln Gly Leu Lys Ile Val His His Ala Glu Lys Thr Leu Ser Ser 
305                 310                 315                 320 


Phe Cys Lys Trp Gln Lys Ser Ile Asn Pro Lys Ser Asp Leu Asn Pro 
                325                 330                 335     


Val His His Asp Val Ala Val Leu Leu Thr Arg Lys Asp Ile Cys Ala 
            340                 345                 350         


Gly Phe Asn Arg Pro Cys Glu Thr Leu Gly Leu Ser His Leu Ser Gly 
        355                 360                 365             


Met Cys Gln Pro His Arg Ser Cys Asn Ile Asn Glu Asp Ser Gly Leu 
    370                 375                 380                 


Pro Leu Ala Phe Thr Ile Ala His Glu Leu Gly His Ser Phe Gly Ile 
385                 390                 395                 400 


Gln His Asp Gly Lys Glu Asn Asp Cys Glu Pro Val Gly Arg His Pro 
                405                 410                 415     


Tyr Ile Met Ser Arg Gln Leu Gln Tyr Asp Pro Thr Pro Leu Thr Trp 
            420                 425                 430         


Ser Lys Cys Ser Glu Glu Tyr Ile Thr Arg Phe Leu Asp Arg Gly Trp 
        435                 440                 445             


Gly Phe Cys Leu Asp Asp Ile Pro Lys Lys Lys Gly Leu Lys Ser Lys 
    450                 455                 460                 


Val Ile Ala Pro Gly Val Ile Tyr Asp Val His His Gln Cys Gln Leu 
465                 470                 475                 480 


Gln Tyr Gly Pro Asn Ala Thr Phe Cys Gln Glu Val Glu Asn Val Cys 
                485                 490                 495     


Gln Thr Leu Trp Cys Ser Val Lys Gly Phe Cys Arg Ser Lys Leu Asp 
            500                 505                 510         


Ala Ala Ala Asp Gly Thr Gln Cys Gly Glu Lys Lys Trp Cys Met Ala 
        515                 520                 525             


Gly Lys Cys Ile Thr Val Gly Lys Lys Pro Glu Ser Ile Pro Gly Gly 
    530                 535                 540                 


Trp Gly Arg Trp Ser Pro Trp Ser His Cys Ser Arg Thr Cys Gly Ala 
545                 550                 555                 560 


Gly Val Gln Ser Ala Glu Arg Leu Cys Asn Asn Pro Glu Pro Lys Phe 
                565                 570                 575     


Gly Gly Lys Tyr Cys Thr Gly Glu Arg Lys Arg Tyr Arg Leu Cys Asn 
            580                 585                 590         


Val His Pro Cys Arg Ser Glu Ala Pro Thr Phe Arg Gln Met Gln Cys 
        595                 600                 605             


Ser Glu Phe Asp Thr Val Pro Tyr Lys Asn Glu Leu Tyr His Trp Phe 
    610                 615                 620                 


Pro Ile Phe Asn Pro Gly Tyr Val Asp Ile Gly Leu Ile Pro Lys Gly 
625                 630                 635                 640 


Ala Arg Asp Ile Arg Val Met Glu Ile Glu Gly Ala Gly Asn Phe Leu 
                645                 650                 655     


Ala Ile Arg Ser Glu Asp Pro Glu Lys Tyr Tyr Leu Asn Gly Gly Phe 
            660                 665                 670         


Ile Ile Gln Trp Asn Gly Asn Tyr Lys Leu Ala Gly Thr Val Phe Gln 
        675                 680                 685             


Tyr Asp Arg Lys Gly Asp Leu Glu Lys Leu Met Ala Thr Gly Pro Thr 
    690                 695                 700                 


Asn Glu Ser Val Trp Ile Gln Leu Leu Phe Gln Val Thr Asn Pro Gly 
705                 710                 715                 720 


Ile Lys Tyr Glu Tyr Thr Ile Gln Lys Asp Gly Leu Asp Asn Asp Val 
                725                 730                 735     


Glu Gln Gln Met Tyr Phe Trp Gln Tyr Gly His Trp Thr Glu Cys Ser 
            740                 745                 750         


Val Thr Cys Gly Thr Gly Ile Arg Arg Gln Thr Ala His Cys Ile Lys 
        755                 760                 765             


Lys Gly Arg Gly Met Val Lys Ala Thr Phe Cys Asp Pro Glu Thr Gln 
    770                 775                 780                 


Pro Asn Gly Arg Gln Lys Lys Cys His Glu Lys Ala Cys Pro Pro Arg 
785                 790                 795                 800 


Trp Trp Ala Gly Glu Trp Glu Ala Cys Ser Ala Thr Cys Gly Pro His 
                805                 810                 815     


Gly Glu Lys Lys Arg Thr Val Leu Cys Ile Gln Thr Met Val Ser Asp 
            820                 825                 830         


Glu Gln Ala Leu Pro Pro Thr Asp Cys Gln His Leu Leu Lys Pro Lys 
        835                 840                 845             


Thr Leu Leu Ser Cys Asn Arg Asp Ile Leu Cys Pro Ser Asp Trp Thr 
    850                 855                 860                 


Val Gly Asn Trp Ser Glu Cys Ser Val Ser Cys Gly Gly Gly Val Arg 
865                 870                 875                 880 


Ile Arg Ser Val Thr Cys Ala Lys Asn His Asp Glu Pro Cys Asp Val 
                885                 890                 895     


Thr Arg Lys Pro Asn Ser Arg Ala Leu Cys Gly Leu Gln Gln Cys Pro 
            900                 905                 910         


Ser Ser Arg Arg Val Leu Lys Pro Asn Lys Gly Thr Ile Ser Asn Gly 
        915                 920                 925             


Lys Asn Pro Pro Thr Leu Lys Pro Val Pro Pro Pro Thr Ser Arg Pro 
    930                 935                 940                 


Arg Met Leu Thr Thr Pro Thr Gly Pro Glu Ser Met Ser Thr Ser Thr 
945                 950                 955                 960 


Pro Ala Ile Ser Ser Pro Ser Pro Thr Thr Ala Ser Lys Glu Gly Asp 
                965                 970                 975     


Leu Gly Gly Lys Gln Trp Gln Asp Ser Ser Thr Gln Pro Glu Leu Ser 
            980                 985                 990         


Ser Arg Tyr Leu Ile Ser Thr Gly  Ser Thr Ser Gln Pro  Ile Leu Thr 
        995                 1000                 1005             


Ser Gln  Ser Leu Ser Ile Gln  Pro Ser Glu Glu Asn  Val Ser Ser 
    1010                 1015                 1020             


Ser Asp  Thr Gly Pro Thr Ser  Glu Gly Gly Leu Val  Ala Thr Thr 
    1025                 1030                 1035             


Thr Ser  Gly Ser Gly Leu Ser  Ser Ser Arg Asn Pro  Ile Thr Trp 
    1040                 1045                 1050             


Pro Val  Thr Pro Phe Tyr Asn  Thr Leu Thr Lys Gly  Pro Glu Met 
    1055                 1060                 1065             


Glu Ile  His Ser Gly Ser Gly  Glu Glu Arg Glu Gln  Pro Glu Asp 
    1070                 1075                 1080             


Lys Asp  Glu Ser Asn Pro Val  Ile Trp Thr Lys Ile  Arg Val Pro 
    1085                 1090                 1095             


Gly Asn  Asp Ala Pro Val Glu  Ser Thr Glu Met Pro  Leu Ala Pro 
    1100                 1105                 1110             


Pro Leu  Thr Pro Asp Leu Ser  Arg Glu Ser Trp Trp  Pro Pro Phe 
    1115                 1120                 1125             


Ser Thr  Val Met Glu Gly Leu  Leu Pro Ser Gln Arg  Pro Thr Thr 
    1130                 1135                 1140             


Ser Glu  Thr Gly Thr Pro Arg  Val Glu Gly Met Val  Thr Glu Lys 
    1145                 1150                 1155             


Pro Ala  Asn Thr Leu Leu Pro  Leu Gly Gly Asp His  Gln Pro Glu 
    1160                 1165                 1170             


Pro Ser  Gly Lys Thr Ala Asn  Arg Asn His Leu Lys  Leu Pro Asn 
    1175                 1180                 1185             


Asn Met  Asn Gln Thr Lys Ser  Ser Glu Pro Val Leu  Thr Glu Glu 
    1190                 1195                 1200             


Asp Ala  Thr Ser Leu Ile Thr  Glu Gly Phe Leu Leu  Asn Ala Ser 
    1205                 1210                 1215             


Asn Tyr  Lys Gln Leu Thr Asn  Gly His Gly Ser Ala  His Trp Ile 
    1220                 1225                 1230             


Val Gly  Asn Trp Ser Glu Cys  Ser Thr Thr Cys Gly  Leu Gly Ala 
    1235                 1240                 1245             


Tyr Trp  Arg Arg Val Glu Cys  Ser Thr Gln Met Asp  Ser Asp Cys 
    1250                 1255                 1260             


Ala Ala  Ile Gln Arg Pro Asp  Pro Ala Lys Arg Cys  His Leu Arg 
    1265                 1270                 1275             


Pro Cys  Ala Gly Trp Lys Val  Gly Asn Trp Ser Lys  Cys Ser Arg 
    1280                 1285                 1290             


Asn Cys  Ser Gly Gly Phe Lys  Ile Arg Glu Ile Gln  Cys Val Asp 
    1295                 1300                 1305             


Ser Arg  Asp His Arg Asn Leu  Arg Pro Phe His Cys  Gln Phe Leu 
    1310                 1315                 1320             


Ala Gly  Ile Pro Pro Pro Leu  Ser Met Ser Cys Asn  Pro Glu Pro 
    1325                 1330                 1335             


Cys Glu  Ala Trp Gln Val Glu  Pro Trp Ser Gln Cys  Ser Arg Ser 
    1340                 1345                 1350             


Cys Gly  Gly Gly Val Gln Glu  Arg Gly Val Phe Cys  Pro Gly Gly 
    1355                 1360                 1365             


Leu Cys  Asp Trp Thr Lys Arg  Pro Thr Ser Thr Met  Ser Cys Asn 
    1370                 1375                 1380             


Glu His  Leu Cys Cys His Trp  Ala Thr Gly Asn Trp  Asp Leu Cys 
    1385                 1390                 1395             


Ser Thr  Ser Cys Gly Gly Gly  Phe Gln Lys Arg Thr  Val Gln Cys 
    1400                 1405                 1410             


Val Pro  Ser Glu Gly Asn Lys  Thr Glu Asp Gln Asp  Gln Cys Leu 
    1415                 1420                 1425             


Cys Asp  His Lys Pro Arg Pro  Pro Glu Phe Lys Lys  Cys Asn Gln 
    1430                 1435                 1440             


Gln Ala  Cys Lys Lys Ser Ala  Asp Leu Leu Cys Thr  Lys Asp Lys 
    1445                 1450                 1455             


Leu Ser  Ala Ser Phe Cys Gln  Thr Leu Lys Ala Met  Lys Lys Cys 
    1460                 1465                 1470             


Ser Val  Pro Thr Val Arg Ala  Glu Cys Cys Phe Ser  Cys Pro Gln 
    1475                 1480                 1485             


Thr His  Ile Thr His Thr Gln  Arg Gln Arg Arg Gln  Arg Leu Leu 
    1490                 1495                 1500             


Gln Lys  Ser Lys Glu Leu 
    1505                 


<210>  326
<211>  1594
<212>  PRT
<213>  Homo Sapiens

<400>  326

Met Pro Cys Ala Gln Arg Ser Trp Leu Ala Asn Leu Ser Val Val Ala 
1               5                   10                  15      


Gln Leu Leu Asn Phe Gly Ala Leu Cys Tyr Gly Arg Gln Pro Gln Pro 
            20                  25                  30          


Gly Pro Val Arg Phe Pro Asp Arg Arg Gln Glu His Phe Ile Lys Gly 
        35                  40                  45              


Leu Pro Glu Tyr His Val Val Gly Pro Val Arg Val Asp Ala Ser Gly 
    50                  55                  60                  


His Phe Leu Ser Tyr Gly Leu His Tyr Pro Ile Thr Ser Ser Arg Arg 
65                  70                  75                  80  


Lys Arg Asp Leu Asp Gly Ser Glu Asp Trp Val Tyr Tyr Arg Ile Ser 
                85                  90                  95      


His Glu Glu Lys Asp Leu Phe Phe Asn Leu Thr Val Asn Gln Gly Phe 
            100                 105                 110         


Leu Ser Asn Ser Tyr Ile Met Glu Lys Arg Tyr Gly Asn Leu Ser His 
        115                 120                 125             


Val Lys Met Met Ala Ser Ser Ala Pro Leu Cys His Leu Ser Gly Thr 
    130                 135                 140                 


Val Leu Gln Gln Gly Thr Arg Val Gly Thr Ala Ala Leu Ser Ala Cys 
145                 150                 155                 160 


His Gly Leu Thr Gly Phe Phe Gln Leu Pro His Gly Asp Phe Phe Ile 
                165                 170                 175     


Glu Pro Val Lys Lys His Pro Leu Val Glu Gly Gly Tyr His Pro His 
            180                 185                 190         


Ile Val Tyr Arg Arg Gln Lys Val Pro Glu Thr Lys Glu Pro Thr Cys 
        195                 200                 205             


Gly Leu Lys Asp Ser Val Asn Ile Ser Gln Lys Gln Glu Leu Trp Arg 
    210                 215                 220                 


Glu Lys Trp Glu Arg His Asn Leu Pro Ser Arg Ser Leu Ser Arg Arg 
225                 230                 235                 240 


Ser Ile Ser Lys Glu Arg Trp Val Glu Thr Leu Val Val Ala Asp Thr 
                245                 250                 255     


Lys Met Ile Glu Tyr His Gly Ser Glu Asn Val Glu Ser Tyr Ile Leu 
            260                 265                 270         


Thr Ile Met Asn Met Val Thr Gly Leu Phe His Asn Pro Ser Ile Gly 
        275                 280                 285             


Asn Ala Ile His Ile Val Val Val Arg Leu Ile Leu Leu Glu Glu Glu 
    290                 295                 300                 


Glu Gln Gly Leu Lys Ile Val His His Ala Glu Lys Thr Leu Ser Ser 
305                 310                 315                 320 


Phe Cys Lys Trp Gln Lys Ser Ile Asn Pro Lys Ser Asp Leu Asn Pro 
                325                 330                 335     


Val His His Asp Val Ala Val Leu Leu Thr Arg Lys Asp Ile Cys Ala 
            340                 345                 350         


Gly Phe Asn Arg Pro Cys Glu Thr Leu Gly Leu Ser His Leu Ser Gly 
        355                 360                 365             


Met Cys Gln Pro His Arg Ser Cys Asn Ile Asn Glu Asp Ser Gly Leu 
    370                 375                 380                 


Pro Leu Ala Phe Thr Ile Ala His Glu Leu Gly His Ser Phe Gly Ile 
385                 390                 395                 400 


Gln His Asp Gly Lys Glu Asn Asp Cys Glu Pro Val Gly Arg His Pro 
                405                 410                 415     


Tyr Ile Met Ser Arg Gln Leu Gln Tyr Asp Pro Thr Pro Leu Thr Trp 
            420                 425                 430         


Ser Lys Cys Ser Glu Glu Tyr Ile Thr Arg Phe Leu Asp Arg Gly Trp 
        435                 440                 445             


Gly Phe Cys Leu Asp Asp Ile Pro Lys Lys Lys Gly Leu Lys Ser Lys 
    450                 455                 460                 


Val Ile Ala Pro Gly Val Ile Tyr Asp Val His His Gln Cys Gln Leu 
465                 470                 475                 480 


Gln Tyr Gly Pro Asn Ala Thr Phe Cys Gln Glu Val Glu Asn Val Cys 
                485                 490                 495     


Gln Thr Leu Trp Cys Ser Val Lys Gly Phe Cys Arg Ser Lys Leu Asp 
            500                 505                 510         


Ala Ala Ala Asp Gly Thr Gln Cys Gly Glu Lys Lys Trp Cys Met Ala 
        515                 520                 525             


Gly Lys Cys Ile Thr Val Gly Lys Lys Pro Glu Ser Ile Pro Gly Gly 
    530                 535                 540                 


Trp Gly Arg Trp Ser Pro Trp Ser His Cys Ser Arg Thr Cys Gly Ala 
545                 550                 555                 560 


Gly Val Gln Ser Ala Glu Arg Leu Cys Asn Asn Pro Glu Pro Lys Phe 
                565                 570                 575     


Gly Gly Lys Tyr Cys Thr Gly Glu Arg Lys Arg Tyr Arg Leu Cys Asn 
            580                 585                 590         


Val His Pro Cys Arg Ser Glu Ala Pro Thr Phe Arg Gln Met Gln Cys 
        595                 600                 605             


Ser Glu Phe Asp Thr Val Pro Tyr Lys Asn Glu Leu Tyr His Trp Phe 
    610                 615                 620                 


Pro Ile Phe Asn Pro Ala His Pro Cys Glu Leu Tyr Cys Arg Pro Ile 
625                 630                 635                 640 


Asp Gly Gln Phe Ser Glu Lys Met Leu Asp Ala Val Ile Asp Gly Thr 
                645                 650                 655     


Pro Cys Phe Glu Gly Gly Asn Ser Arg Asn Val Cys Ile Asn Gly Ile 
            660                 665                 670         


Cys Lys Met Val Gly Cys Asp Tyr Glu Ile Asp Ser Asn Ala Thr Glu 
        675                 680                 685             


Asp Arg Cys Gly Val Cys Leu Gly Asp Gly Ser Ser Cys Gln Thr Val 
    690                 695                 700                 


Arg Lys Met Phe Lys Gln Lys Glu Gly Ser Gly Tyr Val Asp Ile Gly 
705                 710                 715                 720 


Leu Ile Pro Lys Gly Ala Arg Asp Ile Arg Val Met Glu Ile Glu Gly 
                725                 730                 735     


Ala Gly Asn Phe Leu Ala Ile Arg Ser Glu Asp Pro Glu Lys Tyr Tyr 
            740                 745                 750         


Leu Asn Gly Gly Phe Ile Ile Gln Trp Asn Gly Asn Tyr Lys Leu Ala 
        755                 760                 765             


Gly Thr Val Phe Gln Tyr Asp Arg Lys Gly Asp Leu Glu Lys Leu Met 
    770                 775                 780                 


Ala Thr Gly Pro Thr Asn Glu Ser Val Trp Ile Gln Leu Leu Phe Gln 
785                 790                 795                 800 


Val Thr Asn Pro Gly Ile Lys Tyr Glu Tyr Thr Ile Gln Lys Asp Gly 
                805                 810                 815     


Leu Asp Asn Asp Val Glu Gln Gln Met Tyr Phe Trp Gln Tyr Gly His 
            820                 825                 830         


Trp Thr Glu Cys Ser Val Thr Cys Gly Thr Gly Ile Arg Arg Gln Thr 
        835                 840                 845             


Ala His Cys Ile Lys Lys Gly Arg Gly Met Val Lys Ala Thr Phe Cys 
    850                 855                 860                 


Asp Pro Glu Thr Gln Pro Asn Gly Arg Gln Lys Lys Cys His Glu Lys 
865                 870                 875                 880 


Ala Cys Pro Pro Arg Trp Trp Ala Gly Glu Trp Glu Ala Cys Ser Ala 
                885                 890                 895     


Thr Cys Gly Pro His Gly Glu Lys Lys Arg Thr Val Leu Cys Ile Gln 
            900                 905                 910         


Thr Met Val Ser Asp Glu Gln Ala Leu Pro Pro Thr Asp Cys Gln His 
        915                 920                 925             


Leu Leu Lys Pro Lys Thr Leu Leu Ser Cys Asn Arg Asp Ile Leu Cys 
    930                 935                 940                 


Pro Ser Asp Trp Thr Val Gly Asn Trp Ser Glu Cys Ser Val Ser Cys 
945                 950                 955                 960 


Gly Gly Gly Val Arg Ile Arg Ser Val Thr Cys Ala Lys Asn His Asp 
                965                 970                 975     


Glu Pro Cys Asp Val Thr Arg Lys Pro Asn Ser Arg Ala Leu Cys Gly 
            980                 985                 990         


Leu Gln Gln Cys Pro Ser Ser Arg  Arg Val Leu Lys Pro  Asn Lys Gly 
        995                 1000                 1005             


Thr Ile  Ser Asn Gly Lys Asn  Pro Pro Thr Leu Lys  Pro Val Pro 
    1010                 1015                 1020             


Pro Pro  Thr Ser Arg Pro Arg  Met Leu Thr Thr Pro  Thr Gly Pro 
    1025                 1030                 1035             


Glu Ser  Met Ser Thr Ser Thr  Pro Ala Ile Ser Ser  Pro Ser Pro 
    1040                 1045                 1050             


Thr Thr  Ala Ser Lys Glu Gly  Asp Leu Gly Gly Lys  Gln Trp Gln 
    1055                 1060                 1065             


Asp Ser  Ser Thr Gln Pro Glu  Leu Ser Ser Arg Tyr  Leu Ile Ser 
    1070                 1075                 1080             


Thr Gly  Ser Thr Ser Gln Pro  Ile Leu Thr Ser Gln  Ser Leu Ser 
    1085                 1090                 1095             


Ile Gln  Pro Ser Glu Glu Asn  Val Ser Ser Ser Asp  Thr Gly Pro 
    1100                 1105                 1110             


Thr Ser  Glu Gly Gly Leu Val  Ala Thr Thr Thr Ser  Gly Ser Gly 
    1115                 1120                 1125             


Leu Ser  Ser Ser Arg Asn Pro  Ile Thr Trp Pro Val  Thr Pro Phe 
    1130                 1135                 1140             


Tyr Asn  Thr Leu Thr Lys Gly  Pro Glu Met Glu Ile  His Ser Gly 
    1145                 1150                 1155             


Ser Gly  Glu Glu Arg Glu Gln  Pro Glu Asp Lys Asp  Glu Ser Asn 
    1160                 1165                 1170             


Pro Val  Ile Trp Thr Lys Ile  Arg Val Pro Gly Asn  Asp Ala Pro 
    1175                 1180                 1185             


Val Glu  Ser Thr Glu Met Pro  Leu Ala Pro Pro Leu  Thr Pro Asp 
    1190                 1195                 1200             


Leu Ser  Arg Glu Ser Trp Trp  Pro Pro Phe Ser Thr  Val Met Glu 
    1205                 1210                 1215             


Gly Leu  Leu Pro Ser Gln Arg  Pro Thr Thr Ser Glu  Thr Gly Thr 
    1220                 1225                 1230             


Pro Arg  Val Glu Gly Met Val  Thr Glu Lys Pro Ala  Asn Thr Leu 
    1235                 1240                 1245             


Leu Pro  Leu Gly Gly Asp His  Gln Pro Glu Pro Ser  Gly Lys Thr 
    1250                 1255                 1260             


Ala Asn  Arg Asn His Leu Lys  Leu Pro Asn Asn Met  Asn Gln Thr 
    1265                 1270                 1275             


Lys Ser  Ser Glu Pro Val Leu  Thr Glu Glu Asp Ala  Thr Ser Leu 
    1280                 1285                 1290             


Ile Thr  Glu Gly Phe Leu Leu  Asn Ala Ser Asn Tyr  Lys Gln Leu 
    1295                 1300                 1305             


Thr Asn  Gly His Gly Ser Ala  His Trp Ile Val Gly  Asn Trp Ser 
    1310                 1315                 1320             


Glu Cys  Ser Thr Thr Cys Gly  Leu Gly Ala Tyr Trp  Arg Arg Val 
    1325                 1330                 1335             


Glu Cys  Ser Thr Gln Met Asp  Ser Asp Cys Ala Ala  Ile Gln Arg 
    1340                 1345                 1350             


Pro Asp  Pro Ala Lys Arg Cys  His Leu Arg Pro Cys  Ala Gly Trp 
    1355                 1360                 1365             


Lys Val  Gly Asn Trp Ser Lys  Cys Ser Arg Asn Cys  Ser Gly Gly 
    1370                 1375                 1380             


Phe Lys  Ile Arg Glu Ile Gln  Cys Val Asp Ser Arg  Asp His Arg 
    1385                 1390                 1395             


Asn Leu  Arg Pro Phe His Cys  Gln Phe Leu Ala Gly  Ile Pro Pro 
    1400                 1405                 1410             


Pro Leu  Ser Met Ser Cys Asn  Pro Glu Pro Cys Glu  Ala Trp Gln 
    1415                 1420                 1425             


Val Glu  Pro Trp Ser Gln Cys  Ser Arg Ser Cys Gly  Gly Gly Val 
    1430                 1435                 1440             


Gln Glu  Arg Gly Val Phe Cys  Pro Gly Gly Leu Cys  Asp Trp Thr 
    1445                 1450                 1455             


Lys Arg  Pro Thr Ser Thr Met  Ser Cys Asn Glu His  Leu Cys Cys 
    1460                 1465                 1470             


His Trp  Ala Thr Gly Asn Trp  Asp Leu Cys Ser Thr  Ser Cys Gly 
    1475                 1480                 1485             


Gly Gly  Phe Gln Lys Arg Thr  Val Gln Cys Val Pro  Ser Glu Gly 
    1490                 1495                 1500             


Asn Lys  Thr Glu Asp Gln Asp  Gln Cys Leu Cys Asp  His Lys Pro 
    1505                 1510                 1515             


Arg Pro  Pro Glu Phe Lys Lys  Cys Asn Gln Gln Ala  Cys Lys Lys 
    1520                 1525                 1530             


Ser Ala  Asp Leu Leu Cys Thr  Lys Asp Lys Leu Ser  Ala Ser Phe 
    1535                 1540                 1545             


Cys Gln  Thr Leu Lys Ala Met  Lys Lys Cys Ser Val  Pro Thr Val 
    1550                 1555                 1560             


Arg Ala  Glu Cys Cys Phe Ser  Cys Pro Gln Thr His  Ile Thr His 
    1565                 1570                 1575             


Thr Gln  Arg Gln Arg Arg Gln  Arg Leu Leu Gln Lys  Ser Lys Glu 
    1580                 1585                 1590             


Leu 
    


<210>  327
<211>  232
<212>  PRT
<213>  Homo Sapiens

<400>  327

Met Pro Cys Ala Gln Arg Ser Trp Leu Ala Asn Leu Ser Val Val Ala 
1               5                   10                  15      


Gln Leu Leu Asn Phe Gly Ala Leu Cys Tyr Gly Arg Gln Pro Gln Pro 
            20                  25                  30          


Gly Pro Val Arg Phe Pro Asp Arg Arg Gln Glu His Phe Ile Lys Gly 
        35                  40                  45              


Leu Pro Glu Tyr His Val Val Gly Pro Val Arg Val Asp Ala Ser Gly 
    50                  55                  60                  


His Phe Leu Ser Tyr Gly Leu His Tyr Pro Ile Thr Ser Ser Arg Arg 
65                  70                  75                  80  


Lys Arg Asp Leu Asp Gly Ser Glu Asp Trp Val Tyr Tyr Arg Ile Ser 
                85                  90                  95      


His Glu Glu Lys Asp Leu Phe Phe Asn Leu Thr Val Asn Gln Gly Phe 
            100                 105                 110         


Leu Ser Asn Ser Tyr Ile Met Glu Lys Arg Tyr Gly Asn Leu Ser His 
        115                 120                 125             


Val Lys Met Met Ala Ser Ser Ala Pro Leu Cys His Leu Ser Gly Thr 
    130                 135                 140                 


Val Leu Gln Gln Gly Thr Arg Val Gly Thr Ala Ala Leu Ser Ala Cys 
145                 150                 155                 160 


His Gly Leu Thr Gly Phe Phe Gln Leu Pro His Gly Asp Phe Phe Ile 
                165                 170                 175     


Glu Pro Val Lys Lys His Pro Leu Val Glu Gly Gly Tyr His Pro His 
            180                 185                 190         


Ile Val Tyr Arg Arg Gln Lys Val Pro Glu Thr Lys Glu Pro Thr Cys 
        195                 200                 205             


Gly Leu Lys Gly Ile Val Thr His Met Ser Ser Trp Val Glu Glu Ser 
    210                 215                 220                 


Val Leu Phe Phe Trp Leu Phe Tyr 
225                 230         


<210>  328
<211>  444
<212>  PRT
<213>  Homo Sapiens

<400>  328

Met Ala Ser Asp Gly Ala Ala Pro Arg Ala Gly Leu Ala Trp Ser Pro 
1               5                   10                  15      


Cys Ser Arg Arg Gln Leu Leu Ser Leu Leu Ser Ala Gly Arg Ala Arg 
            20                  25                  30          


Cys Val Trp Asp Pro Pro Arg Pro Gln Pro Gly Ser Ala Gly His Pro 
        35                  40                  45              


Pro Asp Ala Gln Pro Gly Leu Tyr Tyr Ser Ala Asn Glu Gln Cys Arg 
    50                  55                  60                  


Val Ala Phe Gly Pro Lys Ala Val Ala Cys Thr Phe Ala Arg Glu His 
65                  70                  75                  80  


Leu Asp Met Cys Gln Ala Leu Ser Cys His Thr Asp Pro Leu Asp Gln 
                85                  90                  95      


Ser Ser Cys Ser Arg Leu Leu Val Pro Leu Leu Asp Gly Thr Glu Cys 
            100                 105                 110         


Gly Val Glu Lys Trp Cys Ser Lys Gly Arg Cys Arg Ser Leu Val Glu 
        115                 120                 125             


Leu Thr Pro Ile Ala Ala Val His Gly Arg Trp Ser Ser Trp Gly Pro 
    130                 135                 140                 


Arg Ser Pro Cys Ser Arg Ser Cys Gly Gly Gly Val Val Thr Arg Arg 
145                 150                 155                 160 


Arg Gln Cys Asn Asn Pro Arg Pro Ala Phe Gly Gly Arg Ala Cys Val 
                165                 170                 175     


Gly Ala Asp Leu Gln Ala Glu Met Cys Asn Thr Gln Ala Cys Glu Lys 
            180                 185                 190         


Thr Gln Leu Glu Phe Met Ser Gln Gln Cys Ala Arg Thr Asp Gly Gln 
        195                 200                 205             


Pro Leu Arg Ser Ser Pro Gly Gly Ala Ser Phe Tyr His Trp Gly Ala 
    210                 215                 220                 


Ala Val Pro His Ser Gln Gly Asp Ala Leu Cys Arg His Met Cys Arg 
225                 230                 235                 240 


Ala Ile Gly Glu Ser Phe Ile Met Lys Arg Gly Asp Ser Phe Leu Asp 
                245                 250                 255     


Gly Thr Arg Cys Met Pro Ser Gly Pro Arg Glu Asp Gly Thr Leu Ser 
            260                 265                 270         


Leu Cys Val Ser Gly Ser Cys Arg Thr Phe Gly Cys Asp Gly Arg Met 
        275                 280                 285             


Asp Ser Gln Gln Val Trp Asp Arg Cys Gln Val Cys Gly Gly Asp Asn 
    290                 295                 300                 


Ser Thr Cys Ser Pro Arg Lys Gly Ser Phe Thr Ala Gly Arg Ala Arg 
305                 310                 315                 320 


Glu Tyr Val Thr Phe Leu Thr Val Thr Pro Asn Leu Thr Ser Val Tyr 
                325                 330                 335     


Ile Ala Asn His Arg Pro Leu Phe Thr His Leu Ala Val Arg Ile Gly 
            340                 345                 350         


Gly Arg Tyr Val Val Ala Gly Lys Met Ser Ile Ser Pro Asn Thr Thr 
        355                 360                 365             


Tyr Pro Ser Leu Leu Glu Asp Gly Arg Val Glu Tyr Arg Val Ala Leu 
    370                 375                 380                 


Thr Glu Asp Arg Leu Pro Arg Leu Glu Glu Ile Arg Ile Trp Gly Pro 
385                 390                 395                 400 


Leu Gln Glu Asp Ala Asp Ile Gln Val Gly Gly Val Arg Ala Gln Leu 
                405                 410                 415     


Met His Ile Ser Trp Trp Ser Arg Pro Gly Leu Gly Glu Arg Asp Leu 
            420                 425                 430         


Cys Ala Arg Gly Arg Trp Pro Gly Gly Ser Ser Asp 
        435                 440                 


<210>  329
<211>  276
<212>  PRT
<213>  Homo Sapiens

<400>  329

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Arg Ile Cys Ala Arg Pro Ser Pro Ala Thr Gln Thr 
225                 230                 235                 240 


Arg Trp Thr Lys Ala Ala Ala Ala Ala Ser Ser Phe Leu Ser Trp Met 
                245                 250                 255     


Gly Gln Asn Val Ala Trp Arg Ser Gly Ala Pro Arg Val Ala Ala Ala 
            260                 265                 270         


Pro Trp Trp Ser 
        275     


<210>  330
<211>  1371
<212>  PRT
<213>  Homo Sapiens

<400>  330

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Ala  Cys Gly Arg Gln His  Leu Glu Pro 
    1130                 1135                 1140             


Thr Gly  Thr Ile Asp Met Arg  Gly Pro Gly Gln Ala  Asp Cys Ala 
    1145                 1150                 1155             


Val Ala  Ile Gly Arg Pro Leu  Gly Glu Val Val Thr  Leu Arg Val 
    1160                 1165                 1170             


Leu Glu  Ser Ser Leu Asn Cys  Ser Ala Gly Asp Met  Leu Leu Leu 
    1175                 1180                 1185             


Trp Gly  Arg Leu Thr Trp Arg  Lys Met Cys Arg Lys  Leu Leu Asp 
    1190                 1195                 1200             


Met Thr  Phe Ser Ser Lys Thr  Asn Thr Leu Val Val  Arg Gln Arg 
    1205                 1210                 1215             


Cys Gly  Arg Pro Gly Gly Gly  Val Leu Leu Arg Tyr  Gly Ser Gln 
    1220                 1225                 1230             


Leu Ala  Pro Glu Thr Phe Tyr  Arg Glu Cys Asp Met  Gln Leu Phe 
    1235                 1240                 1245             


Gly Pro  Trp Gly Glu Ile Val  Ser Pro Ser Leu Ser  Pro Ala Thr 
    1250                 1255                 1260             


Ser Asn  Ala Gly Gly Cys Arg  Leu Phe Ile Asn Val  Ala Pro His 
    1265                 1270                 1275             


Ala Arg  Ile Ala Ile His Ala  Leu Ala Thr Asn Met  Gly Ala Gly 
    1280                 1285                 1290             


Thr Glu  Gly Ala Asn Ala Ser  Tyr Ile Leu Ile Arg  Asp Thr His 
    1295                 1300                 1305             


Ser Leu  Arg Thr Thr Ala Phe  His Gly Gln Gln Val  Leu Tyr Trp 
    1310                 1315                 1320             


Glu Ser  Glu Ser Ser Gln Ala  Glu Met Glu Phe Ser  Glu Gly Phe 
    1325                 1330                 1335             


Leu Lys  Ala Gln Ala Ser Leu  Arg Gly Gln Tyr Trp  Thr Leu Gln 
    1340                 1345                 1350             


Ser Trp  Val Pro Glu Met Gln  Asp Pro Gln Ser Trp  Lys Gly Lys 
    1355                 1360                 1365             


Glu Gly  Thr 
    1370     


<210>  331
<211>  1340
<212>  PRT
<213>  Homo Sapiens

<400>  331

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala 
        275                 280                 285             


Val Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu 
    290                 295                 300                 


Ser Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu 
305                 310                 315                 320 


Val Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser 
                325                 330                 335     


Lys Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val 
            340                 345                 350         


His Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser 
        355                 360                 365             


Cys Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg 
    370                 375                 380                 


Pro Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu 
385                 390                 395                 400 


Met Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser 
                405                 410                 415     


Gln Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly 
            420                 425                 430         


Gly Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly 
        435                 440                 445             


Asp Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile 
    450                 455                 460                 


Met Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser 
465                 470                 475                 480 


Gly Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys 
                485                 490                 495     


Arg Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp 
            500                 505                 510         


Arg Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys 
        515                 520                 525             


Gly Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr 
    530                 535                 540                 


Val Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu 
545                 550                 555                 560 


Phe Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly 
                565                 570                 575     


Lys Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp 
            580                 585                 590         


Gly Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg 
        595                 600                 605             


Leu Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile 
    610                 615                 620                 


Gln Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro 
625                 630                 635                 640 


Asp Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val 
                645                 650                 655     


Trp Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu 
            660                 665                 670         


Arg Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val 
        675                 680                 685             


Glu Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu 
    690                 695                 700                 


Ala Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe 
705                 710                 715                 720 


Gly Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val 
                725                 730                 735     


Arg Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala 
            740                 745                 750         


Arg Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys 
        755                 760                 765             


Asn Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser 
    770                 775                 780                 


Cys Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys 
785                 790                 795                 800 


Val Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly 
                805                 810                 815     


Ser Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser 
            820                 825                 830         


Cys Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys 
        835                 840                 845             


Ala Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His 
    850                 855                 860                 


Val Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly 
865                 870                 875                 880 


Leu Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro 
                885                 890                 895     


Val Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg 
            900                 905                 910         


Glu Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu 
        915                 920                 925             


Ala Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu 
    930                 935                 940                 


Tyr Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu 
945                 950                 955                 960 


Asp Thr Gln Cys Gln Gly Leu Pro Arg Pro Glu Pro Gln Glu Ala Cys 
                965                 970                 975     


Ser Leu Glu Pro Cys Pro Pro Arg Trp Lys Val Met Ser Leu Gly Pro 
            980                 985                 990         


Cys Ser Ala Ser Cys Gly Leu Gly  Thr Ala Arg Arg Ser  Val Ala Cys 
        995                 1000                 1005             


Val Gln  Leu Asp Gln Gly Gln  Asp Val Glu Val Asp  Glu Ala Ala 
    1010                 1015                 1020             


Cys Ala  Ala Leu Val Arg Pro  Glu Ala Ser Val Pro  Cys Leu Ile 
    1025                 1030                 1035             


Ala Asp  Cys Thr Tyr Arg Trp  His Val Gly Thr Trp  Met Glu Cys 
    1040                 1045                 1050             


Ser Val  Ser Cys Gly Asp Gly  Ile Gln Arg Arg Arg  Asp Thr Cys 
    1055                 1060                 1065             


Leu Gly  Pro Gln Ala Gln Ala  Pro Val Pro Ala Asp  Phe Cys Gln 
    1070                 1075                 1080             


His Leu  Pro Lys Pro Val Thr  Val Arg Gly Cys Trp  Ala Gly Pro 
    1085                 1090                 1095             


Cys Val  Gly Gln Gly Ala Cys  Gly Arg Gln His Leu  Glu Pro Thr 
    1100                 1105                 1110             


Gly Thr  Ile Asp Met Arg Gly  Pro Gly Gln Ala Asp  Cys Ala Val 
    1115                 1120                 1125             


Ala Ile  Gly Arg Pro Leu Gly  Glu Val Val Thr Leu  Arg Val Leu 
    1130                 1135                 1140             


Glu Ser  Ser Leu Asn Cys Ser  Ala Gly Asp Met Leu  Leu Leu Trp 
    1145                 1150                 1155             


Gly Arg  Leu Thr Trp Arg Lys  Met Cys Arg Lys Leu  Leu Asp Met 
    1160                 1165                 1170             


Thr Phe  Ser Ser Lys Thr Asn  Thr Leu Val Val Arg  Gln Arg Cys 
    1175                 1180                 1185             


Gly Arg  Pro Gly Gly Gly Val  Leu Leu Arg Tyr Gly  Ser Gln Leu 
    1190                 1195                 1200             


Ala Pro  Glu Thr Phe Tyr Arg  Glu Cys Asp Met Gln  Leu Phe Gly 
    1205                 1210                 1215             


Pro Trp  Gly Glu Ile Val Ser  Pro Ser Leu Ser Pro  Ala Thr Ser 
    1220                 1225                 1230             


Asn Ala  Gly Gly Cys Arg Leu  Phe Ile Asn Val Ala  Pro His Ala 
    1235                 1240                 1245             


Arg Ile  Ala Ile His Ala Leu  Ala Thr Asn Met Gly  Ala Gly Thr 
    1250                 1255                 1260             


Glu Gly  Ala Asn Ala Ser Tyr  Ile Leu Ile Arg Asp  Thr His Ser 
    1265                 1270                 1275             


Leu Arg  Thr Thr Ala Phe His  Gly Gln Gln Val Leu  Tyr Trp Glu 
    1280                 1285                 1290             


Ser Glu  Ser Ser Gln Ala Glu  Met Glu Phe Ser Glu  Gly Phe Leu 
    1295                 1300                 1305             


Lys Ala  Gln Ala Ser Leu Arg  Gly Gln Tyr Trp Thr  Leu Gln Ser 
    1310                 1315                 1320             


Trp Val  Pro Glu Met Gln Asp  Pro Gln Ser Trp Lys  Gly Lys Glu 
    1325                 1330                 1335             


Gly Thr  
    1340 


<210>  332
<211>  1427
<212>  PRT
<213>  Homo Sapiens

<400>  332

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ala Ala  Ala Pro Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Pro 
    1160                 1165                 1170             


Gln Pro  Arg Arg Leu Leu Pro  Gly Pro Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr 
    1415                 1420                 1425         


<210>  333
<211>  344
<212>  PRT
<213>  Homo Sapiens

<400>  333

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Arg Pro Val Pro Pro Ser Pro Leu Pro Leu Leu Ala Thr His 
        275                 280                 285             


Leu Cys Ala Gly Arg Ser Leu Ser Leu Gly Pro Ser Gln Glu Pro Ala 
    290                 295                 300                 


Pro Gly Gly Gly Arg Gly Pro Arg Thr Pro Val Pro Thr His Lys Arg 
305                 310                 315                 320 


Pro Arg Phe Gln Thr Leu Pro Ser Ser Cys Pro Leu Leu Arg Pro Ala 
                325                 330                 335     


Ser Ser Arg Cys Thr Pro Arg Asp 
            340                 


<210>  334
<211>  344
<212>  PRT
<213>  Homo Sapiens

<400>  334

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Arg Pro Val Pro Pro Ser Pro Leu Pro Leu Leu Ala Thr His 
        275                 280                 285             


Leu Cys Ala Gly Arg Ser Leu Ser Leu Gly Pro Ser Gln Glu Pro Ala 
    290                 295                 300                 


Pro Gly Gly Gly Arg Gly Pro Arg Thr Pro Val Pro Thr His Lys Arg 
305                 310                 315                 320 


Pro Arg Phe Gln Thr Leu Pro Ser Ser Cys Pro Leu Leu Arg Pro Ala 
                325                 330                 335     


Ser Ser Arg Cys Thr Pro Arg Asp 
            340                 


<210>  335
<211>  223
<212>  PRT
<213>  Homo Sapiens

<400>  335

Met Arg Gly Pro Gly Gln Ala Asp Cys Ala Val Ala Ile Gly Arg Pro 
1               5                   10                  15      


Leu Gly Glu Val Val Thr Leu Arg Val Leu Glu Ser Ser Leu Asn Cys 
            20                  25                  30          


Ser Ala Gly Asp Met Leu Leu Leu Trp Gly Arg Leu Thr Trp Arg Lys 
        35                  40                  45              


Met Cys Arg Lys Leu Leu Asp Met Thr Phe Ser Ser Lys Thr Asn Thr 
    50                  55                  60                  


Leu Val Val Arg Gln Arg Cys Gly Arg Pro Gly Gly Gly Val Leu Leu 
65                  70                  75                  80  


Arg Tyr Gly Ser Gln Leu Ala Pro Glu Thr Phe Tyr Arg Glu Cys Asp 
                85                  90                  95      


Met Gln Leu Phe Gly Pro Trp Gly Glu Ile Val Ser Pro Ser Leu Ser 
            100                 105                 110         


Pro Ala Thr Ser Asn Ala Gly Gly Cys Arg Leu Phe Ile Asn Val Ala 
        115                 120                 125             


Pro His Ala Arg Ile Ala Ile His Ala Leu Ala Thr Asn Met Gly Ala 
    130                 135                 140                 


Gly Thr Glu Gly Ala Asn Ala Ser Tyr Ile Leu Ile Arg Asp Thr His 
145                 150                 155                 160 


Ser Leu Arg Thr Thr Ala Phe His Gly Gln Gln Val Leu Tyr Trp Glu 
                165                 170                 175     


Ser Glu Ser Ser Gln Ala Glu Met Glu Phe Ser Glu Gly Phe Leu Lys 
            180                 185                 190         


Ala Gln Ala Ser Leu Arg Gly Gln Tyr Trp Thr Leu Gln Ser Trp Val 
        195                 200                 205             


Pro Glu Met Gln Asp Pro Gln Ser Trp Lys Gly Lys Glu Gly Thr 
    210                 215                 220             


<210>  336
<211>  1226
<212>  PRT
<213>  Homo Sapiens

<400>  336

Met Ala Pro Leu Arg Ala Leu Leu Ser Tyr Leu Leu Pro Leu His Cys 
1               5                   10                  15      


Ala Leu Cys Ala Ala Ala Gly Ser Arg Thr Pro Glu Leu His Leu Ser 
            20                  25                  30          


Gly Lys Leu Ser Asp Tyr Gly Val Thr Val Pro Cys Ser Thr Asp Phe 
        35                  40                  45              


Arg Gly Arg Phe Leu Ser His Val Val Ser Gly Pro Ala Ala Ala Ser 
    50                  55                  60                  


Ala Gly Ser Met Val Val Asp Thr Pro Pro Thr Leu Pro Arg His Ser 
65                  70                  75                  80  


Ser His Leu Arg Val Ala Arg Ser Pro Leu His Pro Gly Gly Thr Leu 
                85                  90                  95      


Trp Pro Gly Arg Val Gly Arg His Ser Leu Tyr Phe Asn Val Thr Val 
            100                 105                 110         


Phe Gly Lys Glu Leu His Leu Arg Leu Arg Pro Asn Arg Arg Leu Val 
        115                 120                 125             


Val Pro Gly Ser Ser Val Glu Trp Gln Glu Asp Phe Arg Glu Leu Phe 
    130                 135                 140                 


Arg Gln Pro Leu Arg Gln Glu Cys Val Tyr Thr Gly Gly Val Thr Gly 
145                 150                 155                 160 


Met Pro Gly Ala Ala Val Ala Ile Ser Asn Cys Asp Gly Leu Ala Gly 
                165                 170                 175     


Leu Ile Arg Thr Asp Ser Thr Asp Phe Phe Ile Glu Pro Leu Glu Arg 
            180                 185                 190         


Gly Gln Gln Glu Lys Glu Ala Ser Gly Arg Thr His Val Val Tyr Arg 
        195                 200                 205             


Arg Glu Ala Val Gln Gln Glu Trp Ala Glu Pro Asp Gly Asp Leu His 
    210                 215                 220                 


Asn Glu Ala Phe Gly Leu Gly Asp Leu Pro Asn Leu Leu Gly Leu Val 
225                 230                 235                 240 


Gly Asp Gln Leu Gly Asp Thr Glu Arg Lys Arg Arg His Ala Lys Pro 
                245                 250                 255     


Gly Ser Tyr Ser Ile Glu Val Leu Leu Val Val Asp Asp Ser Val Val 
            260                 265                 270         


Arg Phe His Gly Lys Glu His Val Gln Asn Tyr Val Leu Thr Leu Met 
        275                 280                 285             


Asn Ile Val Asp Glu Ile Tyr His Asp Glu Ser Leu Gly Val His Ile 
    290                 295                 300                 


Asn Ile Ala Leu Val Arg Leu Ile Met Val Gly Tyr Arg Gln Ser Leu 
305                 310                 315                 320 


Ser Leu Ile Glu Arg Gly Asn Pro Ser Arg Ser Leu Glu Gln Val Cys 
                325                 330                 335     


Arg Trp Ala His Ser Gln Gln Arg Gln Asp Pro Ser His Ala Glu His 
            340                 345                 350         


His Asp His Val Val Phe Leu Thr Arg Gln Asp Phe Gly Pro Ser Gly 
        355                 360                 365             


Met Gln Gly Tyr Ala Pro Val Thr Gly Met Cys His Pro Leu Arg Ser 
    370                 375                 380                 


Cys Ala Leu Asn His Glu Asp Gly Phe Ser Ser Ala Phe Val Ile Ala 
385                 390                 395                 400 


His Glu Thr Gly His Val Leu Gly Met Glu His Asp Gly Gln Gly Asn 
                405                 410                 415     


Gly Cys Ala Asp Glu Thr Ser Leu Gly Ser Val Met Ala Pro Leu Val 
            420                 425                 430         


Gln Ala Ala Phe His Arg Phe His Trp Ser Arg Cys Ser Lys Leu Glu 
        435                 440                 445             


Leu Ser Arg Tyr Leu Pro Ser Tyr Asp Cys Leu Leu Asp Asp Pro Phe 
    450                 455                 460                 


Asp Pro Ala Trp Pro Gln Pro Pro Glu Leu Pro Gly Ile Asn Tyr Ser 
465                 470                 475                 480 


Met Asp Glu Gln Cys Arg Phe Asp Phe Gly Ser Gly Tyr Gln Thr Cys 
                485                 490                 495     


Leu Ala Phe Arg Thr Phe Glu Pro Cys Lys Gln Leu Trp Cys Ser His 
            500                 505                 510         


Pro Asp Asn Pro Tyr Phe Cys Lys Thr Lys Lys Gly Pro Pro Leu Asp 
        515                 520                 525             


Gly Thr Glu Cys Ala Pro Gly Lys Trp Cys Phe Lys Gly His Cys Ile 
    530                 535                 540                 


Trp Lys Ser Pro Glu Gln Thr Tyr Gly Gln Asp Gly Gly Trp Ser Ser 
545                 550                 555                 560 


Trp Thr Lys Phe Gly Ser Cys Ser Arg Ser Cys Gly Gly Gly Val Arg 
                565                 570                 575     


Ser Arg Ser Arg Ser Cys Asn Asn Pro Ser Pro Ala Tyr Gly Gly Arg 
            580                 585                 590         


Leu Cys Leu Gly Pro Met Phe Glu Tyr Gln Val Cys Asn Ser Glu Glu 
        595                 600                 605             


Cys Pro Gly Thr Tyr Glu Asp Phe Arg Ala Gln Gln Cys Ala Lys Arg 
    610                 615                 620                 


Asn Ser Tyr Tyr Val His Gln Asn Ala Lys His Ser Trp Val Pro Tyr 
625                 630                 635                 640 


Glu Pro Asp Asp Asp Ala Gln Lys Cys Glu Leu Ile Cys Gln Ser Ala 
                645                 650                 655     


Asp Thr Gly Asp Val Val Phe Met Asn Gln Val Val His Asp Gly Thr 
            660                 665                 670         


Arg Cys Ser Tyr Arg Asp Pro Tyr Ser Val Cys Ala Arg Gly Glu Cys 
        675                 680                 685             


Val Pro Val Gly Cys Asp Lys Glu Val Gly Ser Met Lys Ala Asp Asp 
    690                 695                 700                 


Lys Cys Gly Val Cys Gly Gly Asp Asn Ser His Cys Arg Thr Val Lys 
705                 710                 715                 720 


Gly Thr Leu Gly Lys Ala Ser Lys Gln Ala Gly Ala Leu Lys Leu Val 
                725                 730                 735     


Gln Ile Pro Ala Gly Ala Arg His Ile Gln Ile Glu Ala Leu Glu Lys 
            740                 745                 750         


Ser Pro His Arg Ile Val Val Lys Asn Gln Val Thr Gly Ser Phe Ile 
        755                 760                 765             


Leu Asn Pro Lys Gly Lys Glu Ala Thr Ser Arg Thr Phe Thr Ala Met 
    770                 775                 780                 


Gly Leu Glu Trp Glu Asp Ala Val Glu Asp Ala Lys Glu Ser Leu Lys 
785                 790                 795                 800 


Thr Ser Gly Pro Leu Pro Glu Ala Ile Ala Ile Leu Ala Leu Pro Pro 
                805                 810                 815     


Thr Glu Gly Gly Pro Arg Ser Ser Leu Ala Tyr Lys Tyr Val Ile His 
            820                 825                 830         


Glu Asp Leu Leu Pro Leu Ile Gly Ser Asn Asn Val Leu Leu Glu Glu 
        835                 840                 845             


Met Asp Thr Tyr Glu Trp Ala Leu Lys Ser Trp Ala Pro Cys Ser Lys 
    850                 855                 860                 


Ala Cys Gly Gly Gly Ile Gln Phe Thr Lys Tyr Gly Cys Arg Arg Arg 
865                 870                 875                 880 


Arg Asp His His Met Val Gln Arg His Leu Cys Asp His Lys Lys Arg 
                885                 890                 895     


Pro Lys Pro Ile Arg Arg Arg Cys Asn Gln His Pro Cys Ser Gln Pro 
            900                 905                 910         


Val Trp Val Thr Glu Glu Trp Gly Ala Cys Ser Arg Ser Cys Gly Lys 
        915                 920                 925             


Leu Gly Val Gln Thr Arg Gly Ile Gln Cys Leu Leu Pro Leu Ser Asn 
    930                 935                 940                 


Gly Thr His Lys Val Met Pro Ala Lys Ala Cys Ala Gly Asp Arg Pro 
945                 950                 955                 960 


Glu Ala Arg Arg Pro Cys Leu Arg Val Pro Cys Pro Ala Gln Trp Arg 
                965                 970                 975     


Leu Gly Ala Trp Ser Gln Cys Ser Ala Thr Cys Gly Glu Gly Ile Gln 
            980                 985                 990         


Gln Arg Gln Val Val Cys Arg Thr  Asn Ala Asn Ser Leu  Gly His Cys 
        995                 1000                 1005             


Glu Gly  Asp Arg Pro Asp Thr  Val Gln Val Cys Ser  Leu Pro Ala 
    1010                 1015                 1020             


Cys Gly  Gly Asn His Gln Asn  Ser Thr Val Arg Ala  Asp Val Trp 
    1025                 1030                 1035             


Glu Leu  Gly Thr Pro Glu Gly  Gln Trp Val Pro Gln  Ser Glu Pro 
    1040                 1045                 1050             


Leu His  Pro Ile Asn Lys Ile  Ser Ser Thr Glu Pro  Cys Thr Gly 
    1055                 1060                 1065             


Asp Arg  Ser Val Phe Cys Gln  Met Glu Val Leu Asp  Arg Tyr Cys 
    1070                 1075                 1080             


Ser Ile  Pro Gly Tyr His Arg  Leu Cys Cys Val Ser  Cys Ile Lys 
    1085                 1090                 1095             


Lys Ala  Ser Gly Pro Asn Pro  Gly Pro Asp Pro Gly  Pro Thr Ser 
    1100                 1105                 1110             


Leu Pro  Pro Phe Ser Thr Pro  Gly Ser Pro Leu Pro  Gly Pro Gln 
    1115                 1120                 1125             


Asp Pro  Ala Asp Ala Ala Glu  Pro Pro Gly Lys Pro  Thr Gly Ser 
    1130                 1135                 1140             


Glu Asp  His Gln His Gly Arg  Ala Thr Gln Leu Pro  Gly Ala Leu 
    1145                 1150                 1155             


Asp Thr  Ser Ser Pro Gly Thr  Gln His Pro Phe Ala  Pro Glu Thr 
    1160                 1165                 1170             


Pro Ile  Pro Gly Ala Ser Trp  Ser Ile Ser Pro Thr  Thr Pro Gly 
    1175                 1180                 1185             


Gly Leu  Pro Trp Gly Trp Thr  Gln Thr Pro Thr Pro  Val Pro Glu 
    1190                 1195                 1200             


Asp Lys  Gly Gln Pro Gly Glu  Asp Leu Arg His Pro  Gly Thr Ser 
    1205                 1210                 1215             


Leu Pro  Ala Ala Ser Pro Val  Thr 
    1220                 1225     


<210>  337
<211>  1223
<212>  PRT
<213>  Homo Sapiens

<400>  337

Met Ala Pro Leu Arg Ala Leu Leu Ser Tyr Leu Leu Pro Leu His Cys 
1               5                   10                  15      


Ala Leu Cys Ala Ala Ala Gly Ser Arg Thr Pro Glu Leu His Leu Ser 
            20                  25                  30          


Gly Lys Leu Ser Asp Tyr Gly Val Thr Val Pro Cys Ser Thr Asp Phe 
        35                  40                  45              


Arg Gly Arg Phe Leu Ser His Val Val Ser Gly Pro Ala Ala Ala Ser 
    50                  55                  60                  


Ala Gly Ser Met Val Val Asp Thr Pro Pro Thr Leu Pro Arg His Ser 
65                  70                  75                  80  


Ser His Leu Arg Val Ala Arg Ser Pro Leu His Pro Gly Gly Thr Leu 
                85                  90                  95      


Trp Pro Gly Arg Val Gly Arg His Ser Leu Tyr Phe Asn Val Thr Val 
            100                 105                 110         


Phe Gly Lys Glu Leu His Leu Arg Leu Arg Pro Asn Arg Arg Leu Val 
        115                 120                 125             


Val Pro Gly Ser Ser Val Glu Trp Gln Glu Asp Phe Arg Glu Leu Phe 
    130                 135                 140                 


Arg Gln Pro Leu Arg Gln Glu Cys Val Tyr Thr Gly Gly Val Thr Gly 
145                 150                 155                 160 


Met Pro Gly Ala Ala Val Ala Ile Ser Asn Cys Asp Gly Leu Ala Gly 
                165                 170                 175     


Leu Ile Arg Thr Asp Ser Thr Asp Phe Phe Ile Glu Pro Leu Glu Arg 
            180                 185                 190         


Gly Gln Gln Glu Lys Glu Ala Ser Gly Arg Thr His Val Val Tyr Arg 
        195                 200                 205             


Arg Glu Ala Val Gln Gln Glu Trp Ala Glu Pro Asp Gly Asp Leu His 
    210                 215                 220                 


Asn Glu Ala Phe Gly Leu Gly Asp Leu Pro Asn Leu Leu Gly Leu Val 
225                 230                 235                 240 


Gly Asp Gln Leu Gly Asp Thr Glu Arg Lys Arg Arg His Ala Lys Pro 
                245                 250                 255     


Gly Ser Tyr Ser Ile Glu Val Leu Leu Val Val Asp Asp Ser Val Val 
            260                 265                 270         


Arg Phe His Gly Lys Glu His Val Gln Asn Tyr Val Leu Thr Leu Met 
        275                 280                 285             


Asn Ile Val Asp Glu Ile Tyr His Asp Glu Ser Leu Gly Val His Ile 
    290                 295                 300                 


Asn Ile Ala Leu Val Arg Leu Ile Met Val Gly Tyr Arg Gln Ser Leu 
305                 310                 315                 320 


Ser Leu Ile Glu Arg Gly Asn Pro Ser Arg Ser Leu Glu Gln Val Cys 
                325                 330                 335     


Arg Trp Ala His Ser Gln Gln Arg Gln Asp Pro Ser His Ala Glu His 
            340                 345                 350         


His Asp His Val Val Phe Leu Thr Arg Gln Asp Phe Gly Pro Ser Gly 
        355                 360                 365             


Tyr Ala Pro Val Thr Gly Met Cys His Pro Leu Arg Ser Cys Ala Leu 
    370                 375                 380                 


Asn His Glu Asp Gly Phe Ser Ser Ala Phe Val Ile Ala His Glu Thr 
385                 390                 395                 400 


Gly His Val Leu Gly Met Glu His Asp Gly Gln Gly Asn Gly Cys Ala 
                405                 410                 415     


Asp Glu Thr Ser Leu Gly Ser Val Met Ala Pro Leu Val Gln Ala Ala 
            420                 425                 430         


Phe His Arg Phe His Trp Ser Arg Cys Ser Lys Leu Glu Leu Ser Arg 
        435                 440                 445             


Tyr Leu Pro Ser Tyr Asp Cys Leu Leu Asp Asp Pro Phe Asp Pro Ala 
    450                 455                 460                 


Trp Pro Gln Pro Pro Glu Leu Pro Gly Ile Asn Tyr Ser Met Asp Glu 
465                 470                 475                 480 


Gln Cys Arg Phe Asp Phe Gly Ser Gly Tyr Gln Thr Cys Leu Ala Phe 
                485                 490                 495     


Arg Thr Phe Glu Pro Cys Lys Gln Leu Trp Cys Ser His Pro Asp Asn 
            500                 505                 510         


Pro Tyr Phe Cys Lys Thr Lys Lys Gly Pro Pro Leu Asp Gly Thr Glu 
        515                 520                 525             


Cys Ala Pro Gly Lys Trp Cys Phe Lys Gly His Cys Ile Trp Lys Ser 
    530                 535                 540                 


Pro Glu Gln Thr Tyr Gly Gln Asp Gly Gly Trp Ser Ser Trp Thr Lys 
545                 550                 555                 560 


Phe Gly Ser Cys Ser Arg Ser Cys Gly Gly Gly Val Arg Ser Arg Ser 
                565                 570                 575     


Arg Ser Cys Asn Asn Pro Ser Pro Ala Tyr Gly Gly Arg Leu Cys Leu 
            580                 585                 590         


Gly Pro Met Phe Glu Tyr Gln Val Cys Asn Ser Glu Glu Cys Pro Gly 
        595                 600                 605             


Thr Tyr Glu Asp Phe Arg Ala Gln Gln Cys Ala Lys Arg Asn Ser Tyr 
    610                 615                 620                 


Tyr Val His Gln Asn Ala Lys His Ser Trp Val Pro Tyr Glu Pro Asp 
625                 630                 635                 640 


Asp Asp Ala Gln Lys Cys Glu Leu Ile Cys Gln Ser Ala Asp Thr Gly 
                645                 650                 655     


Asp Val Val Phe Met Asn Gln Val Val His Asp Gly Thr Arg Cys Ser 
            660                 665                 670         


Tyr Arg Asp Pro Tyr Ser Val Cys Ala Arg Gly Glu Cys Val Pro Val 
        675                 680                 685             


Gly Cys Asp Lys Glu Val Gly Ser Met Lys Ala Asp Asp Lys Cys Gly 
    690                 695                 700                 


Val Cys Gly Gly Asp Asn Ser His Cys Arg Thr Val Lys Gly Thr Leu 
705                 710                 715                 720 


Gly Lys Ala Ser Lys Gln Ala Gly Ala Leu Lys Leu Val Gln Ile Pro 
                725                 730                 735     


Ala Gly Ala Arg His Ile Gln Ile Glu Ala Leu Glu Lys Ser Pro His 
            740                 745                 750         


Arg Ile Val Val Lys Asn Gln Val Thr Gly Ser Phe Ile Leu Asn Pro 
        755                 760                 765             


Lys Gly Lys Glu Ala Thr Ser Arg Thr Phe Thr Ala Met Gly Leu Glu 
    770                 775                 780                 


Trp Glu Asp Ala Val Glu Asp Ala Lys Glu Ser Leu Lys Thr Ser Gly 
785                 790                 795                 800 


Pro Leu Pro Glu Ala Ile Ala Ile Leu Ala Leu Pro Pro Thr Glu Gly 
                805                 810                 815     


Gly Pro Arg Ser Ser Leu Ala Tyr Lys Tyr Val Ile His Glu Asp Leu 
            820                 825                 830         


Leu Pro Leu Ile Gly Ser Asn Asn Val Leu Leu Glu Glu Met Asp Thr 
        835                 840                 845             


Tyr Glu Trp Ala Leu Lys Ser Trp Ala Pro Cys Ser Lys Ala Cys Gly 
    850                 855                 860                 


Gly Gly Ile Gln Phe Thr Lys Tyr Gly Cys Arg Arg Arg Arg Asp His 
865                 870                 875                 880 


His Met Val Gln Arg His Leu Cys Asp His Lys Lys Arg Pro Lys Pro 
                885                 890                 895     


Ile Arg Arg Arg Cys Asn Gln His Pro Cys Ser Gln Pro Val Trp Val 
            900                 905                 910         


Thr Glu Glu Trp Gly Ala Cys Ser Arg Ser Cys Gly Lys Leu Gly Val 
        915                 920                 925             


Gln Thr Arg Gly Ile Gln Cys Leu Leu Pro Leu Ser Asn Gly Thr His 
    930                 935                 940                 


Lys Val Met Pro Ala Lys Ala Cys Ala Gly Asp Arg Pro Glu Ala Arg 
945                 950                 955                 960 


Arg Pro Cys Leu Arg Val Pro Cys Pro Ala Gln Trp Arg Leu Gly Ala 
                965                 970                 975     


Trp Ser Gln Cys Ser Ala Thr Cys Gly Glu Gly Ile Gln Gln Arg Gln 
            980                 985                 990         


Val Val Cys Arg Thr Asn Ala Asn  Ser Leu Gly His Cys  Glu Gly Asp 
        995                 1000                 1005             


Arg Pro  Asp Thr Val Gln Val  Cys Ser Leu Pro Ala  Cys Gly Gly 
    1010                 1015                 1020             


Asn His  Gln Asn Ser Thr Val  Arg Ala Asp Val Trp  Glu Leu Gly 
    1025                 1030                 1035             


Thr Pro  Glu Gly Gln Trp Val  Pro Gln Ser Glu Pro  Leu His Pro 
    1040                 1045                 1050             


Ile Asn  Lys Ile Ser Ser Thr  Glu Pro Cys Thr Gly  Asp Arg Ser 
    1055                 1060                 1065             


Val Phe  Cys Gln Met Glu Val  Leu Asp Arg Tyr Cys  Ser Ile Pro 
    1070                 1075                 1080             


Gly Tyr  His Arg Leu Cys Cys  Val Ser Cys Ile Lys  Lys Ala Ser 
    1085                 1090                 1095             


Gly Pro  Asn Pro Gly Pro Asp  Pro Gly Pro Thr Ser  Leu Pro Pro 
    1100                 1105                 1110             


Phe Ser  Thr Pro Gly Ser Pro  Leu Pro Gly Pro Gln  Asp Pro Ala 
    1115                 1120                 1125             


Asp Ala  Ala Glu Pro Pro Gly  Lys Pro Thr Gly Ser  Glu Asp His 
    1130                 1135                 1140             


Gln His  Gly Arg Ala Thr Gln  Leu Pro Gly Ala Leu  Asp Thr Ser 
    1145                 1150                 1155             


Ser Pro  Gly Thr Gln His Pro  Phe Ala Pro Glu Thr  Pro Ile Pro 
    1160                 1165                 1170             


Gly Ala  Ser Trp Ser Ile Ser  Pro Thr Thr Pro Gly  Gly Leu Pro 
    1175                 1180                 1185             


Trp Gly  Trp Thr Gln Thr Pro  Thr Pro Val Pro Glu  Asp Lys Gly 
    1190                 1195                 1200             


Gln Pro  Gly Glu Asp Leu Arg  His Pro Gly Thr Ser  Leu Pro Ala 
    1205                 1210                 1215             


Ala Ser  Pro Val Thr 
    1220             


<210>  338
<211>  950
<212>  PRT
<213>  Homo Sapiens

<400>  338

Met Leu Leu Leu Gly Ile Leu Thr Leu Ala Phe Ala Gly Arg Thr Ala 
1               5                   10                  15      


Gly Gly Ser Glu Pro Glu Arg Glu Val Val Val Pro Ile Arg Leu Asp 
            20                  25                  30          


Pro Asp Ile Asn Gly Arg Arg Tyr Tyr Trp Arg Gly Pro Glu Asp Ser 
        35                  40                  45              


Gly Asp Gln Gly Leu Ile Phe Gln Ile Thr Ala Phe Gln Glu Asp Phe 
    50                  55                  60                  


Tyr Leu His Leu Thr Pro Asp Ala Gln Phe Leu Ala Pro Ala Phe Ser 
65                  70                  75                  80  


Thr Glu His Leu Gly Val Pro Leu Gln Gly Leu Thr Gly Gly Ser Ser 
                85                  90                  95      


Asp Leu Arg Arg Cys Phe Tyr Ser Gly Asp Val Asn Ala Glu Pro Asp 
            100                 105                 110         


Ser Phe Ala Ala Val Ser Leu Cys Gly Gly Leu Arg Gly Ala Phe Gly 
        115                 120                 125             


Tyr Arg Gly Ala Glu Tyr Val Ile Ser Pro Leu Pro Asn Ala Ser Ala 
    130                 135                 140                 


Pro Ala Ala Gln Arg Asn Ser Gln Gly Ala His Leu Leu Gln Arg Arg 
145                 150                 155                 160 


Gly Val Pro Gly Gly Pro Ser Gly Asp Pro Thr Ser Arg Cys Gly Val 
                165                 170                 175     


Ala Ser Gly Trp Asn Pro Ala Ile Leu Arg Ala Leu Asp Pro Tyr Lys 
            180                 185                 190         


Pro Arg Arg Ala Gly Phe Gly Glu Ser Arg Ser Arg Arg Arg Ser Gly 
        195                 200                 205             


Arg Ala Lys Arg Phe Val Ser Ile Pro Arg Tyr Val Glu Thr Leu Val 
    210                 215                 220                 


Val Ala Asp Glu Ser Met Val Lys Phe His Gly Ala Asp Leu Glu His 
225                 230                 235                 240 


Tyr Leu Leu Thr Leu Leu Ala Thr Ala Ala Arg Leu Tyr Arg His Pro 
                245                 250                 255     


Ser Ile Leu Asn Pro Ile Asn Ile Val Val Val Lys Val Leu Leu Leu 
            260                 265                 270         


Arg Asp Arg Asp Ser Gly Pro Lys Val Thr Gly Asn Ala Ala Leu Thr 
        275                 280                 285             


Leu Arg Asn Phe Cys Ala Trp Gln Lys Lys Leu Asn Lys Val Ser Asp 
    290                 295                 300                 


Lys His Pro Glu Tyr Trp Asp Thr Ala Ile Leu Phe Thr Arg Gln Asp 
305                 310                 315                 320 


Leu Cys Gly Ala Thr Thr Cys Asp Thr Leu Gly Met Ala Asp Val Gly 
                325                 330                 335     


Thr Met Cys Asp Pro Lys Arg Ser Cys Ser Val Ile Glu Asp Asp Gly 
            340                 345                 350         


Leu Pro Ser Ala Phe Thr Thr Ala His Glu Leu Gly His Val Phe Asn 
        355                 360                 365             


Met Pro His Asp Asn Val Lys Val Cys Glu Glu Val Phe Gly Lys Leu 
    370                 375                 380                 


Arg Ala Asn His Met Met Ser Pro Thr Leu Ile Gln Ile Asp Arg Ala 
385                 390                 395                 400 


Asn Pro Trp Ser Ala Cys Ser Ala Ala Ile Ile Thr Asp Phe Leu Asp 
                405                 410                 415     


Ser Gly His Gly Asp Cys Leu Leu Asp Gln Pro Ser Lys Pro Ile Ser 
            420                 425                 430         


Leu Pro Glu Asp Leu Pro Gly Ala Ser Tyr Thr Leu Ser Gln Gln Cys 
        435                 440                 445             


Glu Leu Ala Phe Gly Val Gly Ser Lys Pro Cys Pro Tyr Met Gln Tyr 
    450                 455                 460                 


Cys Thr Lys Leu Trp Cys Thr Gly Lys Ala Lys Gly Gln Met Val Cys 
465                 470                 475                 480 


Gln Thr Arg His Phe Pro Trp Ala Asp Gly Thr Ser Cys Gly Glu Gly 
                485                 490                 495     


Lys Leu Cys Leu Lys Gly Ala Cys Val Glu Arg His Asn Leu Asn Lys 
            500                 505                 510         


His Arg Val Asp Gly Ser Trp Ala Lys Trp Asp Pro Tyr Gly Pro Cys 
        515                 520                 525             


Ser Arg Thr Cys Gly Gly Gly Val Gln Leu Ala Arg Arg Gln Cys Thr 
    530                 535                 540                 


Asn Pro Thr Pro Ala Asn Gly Gly Lys Tyr Cys Glu Gly Val Arg Val 
545                 550                 555                 560 


Lys Tyr Arg Ser Cys Asn Leu Glu Pro Cys Pro Ser Ser Ala Ser Gly 
                565                 570                 575     


Lys Ser Phe Arg Glu Glu Gln Cys Glu Ala Phe Asn Gly Tyr Asn His 
            580                 585                 590         


Ser Thr Asn Arg Leu Thr Leu Ala Val Ala Trp Val Pro Lys Tyr Ser 
        595                 600                 605             


Gly Val Ser Pro Arg Asp Lys Cys Lys Leu Ile Cys Arg Ala Asn Gly 
    610                 615                 620                 


Thr Gly Tyr Phe Tyr Val Leu Ala Pro Lys Val Val Asp Gly Thr Leu 
625                 630                 635                 640 


Cys Ser Pro Asp Ser Thr Ser Val Cys Val Gln Gly Lys Cys Ile Lys 
                645                 650                 655     


Ala Gly Cys Asp Gly Asn Leu Gly Ser Lys Lys Arg Phe Asp Lys Cys 
            660                 665                 670         


Gly Val Cys Gly Gly Asp Asn Lys Ser Cys Lys Lys Val Thr Gly Leu 
        675                 680                 685             


Phe Thr Lys Pro Met His Gly Tyr Asn Phe Val Val Ala Ile Pro Ala 
    690                 695                 700                 


Gly Ala Ser Ser Ile Asp Ile Arg Gln Arg Gly Tyr Lys Gly Leu Ile 
705                 710                 715                 720 


Gly Asp Asp Asn Tyr Leu Ala Leu Lys Asn Ser Gln Gly Lys Tyr Leu 
                725                 730                 735     


Leu Asn Gly His Phe Val Val Ser Ala Val Glu Arg Asp Leu Val Val 
            740                 745                 750         


Lys Gly Ser Leu Leu Arg Tyr Ser Gly Thr Gly Thr Ala Val Glu Ser 
        755                 760                 765             


Leu Gln Ala Ser Arg Pro Ile Leu Glu Pro Leu Thr Val Glu Val Leu 
    770                 775                 780                 


Ser Val Gly Lys Met Thr Pro Pro Arg Val Arg Tyr Ser Phe Tyr Leu 
785                 790                 795                 800 


Pro Lys Glu Pro Arg Glu Asp Lys Ser Ser His Pro Lys Asp Pro Arg 
                805                 810                 815     


Gly Pro Ser Val Leu His Asn Ser Val Leu Ser Leu Ser Asn Gln Val 
            820                 825                 830         


Glu Gln Pro Asp Asp Arg Pro Pro Ala Arg Trp Val Ala Gly Ser Trp 
        835                 840                 845             


Gly Pro Cys Ser Ala Ser Cys Gly Ser Gly Leu Gln Lys Arg Ala Val 
    850                 855                 860                 


Asp Cys Arg Gly Ser Ala Gly Gln Arg Thr Val Pro Ala Cys Asp Ala 
865                 870                 875                 880 


Ala His Arg Pro Val Glu Thr Gln Ala Cys Gly Glu Pro Cys Pro Thr 
                885                 890                 895     


Trp Glu Leu Ser Ala Trp Ser Pro Cys Ser Lys Ser Cys Gly Arg Gly 
            900                 905                 910         


Phe Gln Arg Arg Ser Leu Lys Cys Val Gly His Gly Gly Arg Leu Leu 
        915                 920                 925             


Ala Arg Asp Gln Cys Asn Leu His Arg Lys Pro Gln Glu Leu Asp Phe 
    930                 935                 940                 


Cys Val Leu Arg Pro Cys 
945                 950 


<210>  339
<211>  1224
<212>  PRT
<213>  Homo Sapiens

<400>  339

Met Lys Pro Arg Ala Arg Gly Trp Arg Gly Leu Ala Ala Leu Trp Met 
1               5                   10                  15      


Leu Leu Ala Gln Val Ala Glu Gln Ala Pro Ala Cys Ala Met Gly Pro 
            20                  25                  30          


Ala Ala Ala Ala Pro Gly Ser Pro Ser Val Pro Arg Pro Pro Pro Pro 
        35                  40                  45              


Ala Glu Arg Pro Gly Trp Met Glu Lys Gly Glu Tyr Asp Leu Val Ser 
    50                  55                  60                  


Ala Tyr Glu Val Asp His Arg Gly Asp Tyr Val Ser His Glu Ile Met 
65                  70                  75                  80  


His His Gln Arg Arg Arg Arg Ala Val Pro Val Ser Glu Val Glu Ser 
                85                  90                  95      


Leu His Leu Arg Leu Lys Gly Ser Arg His Asp Phe His Met Asp Leu 
            100                 105                 110         


Arg Thr Ser Ser Ser Leu Val Ala Pro Gly Phe Ile Val Gln Thr Leu 
        115                 120                 125             


Gly Lys Thr Gly Thr Lys Ser Val Gln Thr Leu Pro Pro Glu Asp Phe 
    130                 135                 140                 


Cys Phe Tyr Gln Gly Ser Leu Arg Ser His Arg Asn Ser Ser Val Ala 
145                 150                 155                 160 


Leu Ser Thr Cys Gln Gly Leu Ser Gly Met Ile Arg Thr Glu Glu Ala 
                165                 170                 175     


Asp Tyr Phe Leu Arg Pro Leu Pro Ser His Leu Ser Trp Lys Leu Gly 
            180                 185                 190         


Arg Ala Ala Gln Gly Ser Ser Pro Ser His Val Leu Tyr Lys Arg Ser 
        195                 200                 205             


Thr Glu Pro His Ala Pro Gly Ala Ser Glu Val Leu Val Thr Ser Arg 
    210                 215                 220                 


Thr Trp Glu Leu Ala His Gln Pro Leu His Ser Ser Asp Leu Arg Leu 
225                 230                 235                 240 


Gly Leu Pro Gln Lys Gln His Phe Cys Gly Arg Arg Lys Lys Tyr Met 
                245                 250                 255     


Pro Gln Pro Pro Lys Glu Asp Leu Phe Ile Leu Pro Asp Glu Tyr Lys 
            260                 265                 270         


Ser Cys Leu Arg His Lys Arg Ser Leu Leu Arg Ser His Arg Asn Glu 
        275                 280                 285             


Glu Leu Asn Val Glu Thr Leu Val Val Val Asp Lys Lys Met Met Gln 
    290                 295                 300                 


Asn His Gly His Glu Asn Ile Thr Thr Tyr Val Leu Thr Ile Leu Asn 
305                 310                 315                 320 


Met Val Ser Ala Leu Phe Lys Asp Gly Thr Ile Gly Gly Asn Ile Asn 
                325                 330                 335     


Ile Ala Ile Val Gly Leu Ile Leu Leu Glu Asp Glu Gln Pro Gly Leu 
            340                 345                 350         


Val Ile Ser His His Ala Asp His Thr Leu Ser Ser Phe Cys Gln Trp 
        355                 360                 365             


Gln Ser Gly Leu Met Gly Lys Asp Gly Thr Arg His Asp His Ala Ile 
    370                 375                 380                 


Leu Leu Thr Gly Leu Asp Ile Cys Ser Trp Lys Asn Glu Pro Cys Asp 
385                 390                 395                 400 


Thr Leu Gly Phe Ala Pro Ile Ser Gly Met Cys Ser Lys Tyr Arg Ser 
                405                 410                 415     


Cys Thr Ile Asn Glu Asp Thr Gly Leu Gly Leu Ala Phe Thr Ile Ala 
            420                 425                 430         


His Glu Ser Gly His Asn Phe Gly Met Ile His Asp Gly Glu Gly Asn 
        435                 440                 445             


Met Cys Lys Lys Ser Glu Gly Asn Ile Met Ser Pro Thr Leu Ala Gly 
    450                 455                 460                 


Arg Asn Gly Val Phe Ser Trp Ser Pro Cys Ser Arg Gln Tyr Leu His 
465                 470                 475                 480 


Lys Phe Leu Ser Thr Ala Gln Ala Ile Cys Leu Ala Asp Gln Pro Lys 
                485                 490                 495     


Pro Val Lys Glu Tyr Lys Tyr Pro Glu Lys Leu Pro Gly Glu Leu Tyr 
            500                 505                 510         


Asp Ala Asn Thr Gln Cys Lys Trp Gln Phe Gly Glu Lys Ala Lys Leu 
        515                 520                 525             


Cys Met Leu Asp Phe Lys Lys Asp Ile Cys Lys Ala Leu Trp Cys His 
    530                 535                 540                 


Arg Ile Gly Arg Lys Cys Glu Thr Lys Phe Met Pro Ala Ala Glu Gly 
545                 550                 555                 560 


Thr Ile Cys Gly His Asp Met Trp Cys Arg Gly Gly Gln Cys Val Lys 
                565                 570                 575     


Tyr Gly Asp Glu Gly Pro Lys Pro Thr His Gly His Trp Ser Asp Trp 
            580                 585                 590         


Ser Ser Trp Ser Pro Cys Ser Arg Thr Cys Gly Gly Gly Val Ser His 
        595                 600                 605             


Arg Ser Arg Leu Cys Thr Asn Pro Lys Pro Ser His Gly Gly Lys Phe 
    610                 615                 620                 


Cys Glu Gly Ser Thr Arg Thr Leu Lys Leu Cys Asn Ser Gln Lys Cys 
625                 630                 635                 640 


Pro Arg Asp Ser Val Asp Phe Arg Ala Ala Gln Cys Ala Glu His Asn 
                645                 650                 655     


Ser Arg Arg Phe Arg Gly Arg His Tyr Lys Trp Lys Pro Tyr Thr Gln 
            660                 665                 670         


Val Glu Asp Gln Asp Leu Cys Lys Leu Tyr Cys Ile Ala Glu Gly Phe 
        675                 680                 685             


Asp Phe Phe Phe Ser Leu Ser Asn Lys Val Lys Asp Gly Thr Pro Cys 
    690                 695                 700                 


Ser Glu Asp Ser Arg Asn Val Cys Ile Asp Gly Ile Cys Glu Arg Val 
705                 710                 715                 720 


Gly Cys Asp Asn Val Leu Gly Ser Asp Ala Val Glu Asp Val Cys Gly 
                725                 730                 735     


Val Cys Asn Gly Asn Asn Ser Ala Cys Thr Ile His Arg Gly Leu Tyr 
            740                 745                 750         


Thr Lys His His His Thr Asn Gln Tyr Tyr His Met Val Thr Ile Pro 
        755                 760                 765             


Ser Gly Ala Arg Ser Ile Arg Ile Tyr Glu Met Asn Val Ser Thr Ser 
    770                 775                 780                 


Tyr Ile Ser Val Arg Asn Ala Leu Arg Arg Tyr Tyr Leu Asn Gly His 
785                 790                 795                 800 


Trp Thr Val Asp Trp Pro Gly Arg Tyr Lys Phe Ser Gly Thr Thr Phe 
                805                 810                 815     


Asp Tyr Arg Arg Ser Tyr Asn Glu Pro Glu Asn Leu Ile Ala Thr Gly 
            820                 825                 830         


Pro Thr Asn Glu Thr Leu Ile Val Glu Leu Leu Phe Gln Gly Arg Asn 
        835                 840                 845             


Pro Gly Val Ala Trp Glu Tyr Ser Met Pro Arg Leu Gly Thr Glu Lys 
    850                 855                 860                 


Gln Pro Pro Ala Gln Pro Ser Tyr Thr Trp Ala Ile Val Arg Ser Glu 
865                 870                 875                 880 


Cys Ser Val Ser Cys Gly Gly Gly Gln Met Thr Val Arg Glu Gly Cys 
                885                 890                 895     


Tyr Arg Asp Leu Lys Phe Gln Val Asn Met Ser Phe Cys Asn Pro Lys 
            900                 905                 910         


Thr Arg Pro Val Thr Gly Leu Val Pro Cys Lys Val Ser Ala Cys Pro 
        915                 920                 925             


Pro Ser Trp Ser Val Gly Asn Trp Ser Ala Cys Ser Arg Thr Cys Gly 
    930                 935                 940                 


Gly Gly Ala Gln Ser Arg Pro Val Gln Cys Thr Arg Arg Val His Tyr 
945                 950                 955                 960 


Asp Ser Glu Pro Val Pro Ala Ser Leu Cys Pro Gln Pro Ala Pro Ser 
                965                 970                 975     


Ser Arg Gln Ala Cys Asn Ser Gln Ser Cys Pro Pro Ala Trp Ser Ala 
            980                 985                 990         


Gly Pro Trp Ala Glu Cys Ser His  Thr Cys Gly Lys Gly  Trp Arg Lys 
        995                 1000                 1005             


Arg Ala  Val Ala Cys Lys Ser  Thr Asn Pro Ser Ala  Arg Ala Gln 
    1010                 1015                 1020             


Leu Leu  Pro Asp Ala Val Cys  Thr Ser Glu Pro Lys  Pro Arg Met 
    1025                 1030                 1035             


His Glu  Ala Cys Leu Leu Gln  Arg Cys His Lys Pro  Lys Lys Leu 
    1040                 1045                 1050             


Gln Trp  Leu Val Ser Ala Trp  Ser Gln Cys Ser Val  Thr Cys Glu 
    1055                 1060                 1065             


Arg Gly  Thr Gln Lys Arg Phe  Leu Lys Cys Ala Glu  Lys Tyr Val 
    1070                 1075                 1080             


Ser Gly  Lys Tyr Arg Glu Leu  Ala Ser Lys Lys Cys  Ser His Leu 
    1085                 1090                 1095             


Pro Lys  Pro Ser Leu Glu Leu  Glu Arg Ala Cys Ala  Pro Leu Pro 
    1100                 1105                 1110             


Cys Pro  Arg His Pro Pro Phe  Ala Ala Ala Gly Pro  Ser Arg Gly 
    1115                 1120                 1125             


Ser Trp  Phe Ala Ser Pro Trp  Ser Gln Cys Thr Ala  Ser Cys Gly 
    1130                 1135                 1140             


Gly Gly  Val Gln Thr Arg Ser  Val Gln Cys Leu Ala  Gly Gly Arg 
    1145                 1150                 1155             


Pro Ala  Ser Gly Cys Leu Leu  His Gln Lys Pro Ser  Ala Ser Leu 
    1160                 1165                 1170             


Ala Cys  Asn Thr His Phe Cys  Pro Ile Ala Glu Lys  Lys Asp Ala 
    1175                 1180                 1185             


Phe Cys  Lys Asp Tyr Phe His  Trp Cys Tyr Leu Val  Pro Gln His 
    1190                 1195                 1200             


Gly Met  Cys Ser His Lys Phe  Tyr Gly Lys Gln Cys  Cys Lys Thr 
    1205                 1210                 1215             


Cys Ser  Lys Ser Asn Leu 
    1220                 


<210>  340
<211>  570
<212>  PRT
<213>  Homo Sapiens

<400>  340

Met Lys Pro Arg Ala Arg Gly Trp Arg Gly Leu Ala Ala Leu Trp Met 
1               5                   10                  15      


Leu Leu Ala Gln Val Ala Glu Gln Ala Pro Ala Cys Ala Met Gly Pro 
            20                  25                  30          


Ala Ala Ala Ala Pro Gly Ser Pro Ser Val Pro Arg Pro Pro Pro Pro 
        35                  40                  45              


Ala Glu Arg Pro Gly Trp Met Glu Lys Gly Glu Tyr Asp Leu Val Ser 
    50                  55                  60                  


Ala Tyr Glu Val Asp His Arg Gly Asp Tyr Val Ser His Glu Ile Met 
65                  70                  75                  80  


His His Gln Arg Arg Arg Arg Ala Val Pro Val Ser Glu Val Glu Ser 
                85                  90                  95      


Leu His Leu Arg Leu Lys Gly Ser Arg His Asp Phe His Met Asp Leu 
            100                 105                 110         


Arg Thr Ser Ser Ser Leu Val Ala Pro Gly Phe Ile Val Gln Thr Leu 
        115                 120                 125             


Gly Lys Thr Gly Thr Lys Ser Val Gln Thr Leu Pro Pro Glu Asp Phe 
    130                 135                 140                 


Cys Phe Tyr Gln Gly Ser Leu Arg Ser His Arg Asn Ser Ser Val Ala 
145                 150                 155                 160 


Leu Ser Thr Cys Gln Gly Leu Ser Gly Met Ile Arg Thr Glu Glu Ala 
                165                 170                 175     


Asp Tyr Phe Leu Arg Pro Leu Pro Ser His Leu Ser Trp Lys Leu Gly 
            180                 185                 190         


Arg Ala Ala Gln Gly Ser Ser Pro Ser His Val Leu Tyr Lys Arg Ser 
        195                 200                 205             


Thr Glu Pro His Ala Pro Gly Ala Ser Glu Val Leu Val Thr Ser Arg 
    210                 215                 220                 


Thr Trp Glu Leu Ala His Gln Pro Leu His Ser Ser Asp Leu Arg Leu 
225                 230                 235                 240 


Gly Leu Pro Gln Lys Gln His Phe Cys Gly Arg Arg Lys Lys Tyr Met 
                245                 250                 255     


Pro Gln Pro Pro Lys Glu Asp Leu Phe Ile Leu Pro Asp Glu Tyr Lys 
            260                 265                 270         


Ser Cys Leu Arg His Lys Arg Ser Leu Leu Arg Ser His Arg Asn Glu 
        275                 280                 285             


Glu Leu Asn Val Glu Thr Leu Val Val Val Asp Lys Lys Met Met Gln 
    290                 295                 300                 


Asn His Gly His Glu Asn Ile Thr Thr Tyr Val Leu Thr Ile Leu Asn 
305                 310                 315                 320 


Met Val Ser Ala Leu Phe Lys Asp Gly Thr Ile Gly Gly Asn Ile Asn 
                325                 330                 335     


Ile Ala Ile Val Gly Leu Ile Leu Leu Glu Asp Glu Gln Pro Gly Leu 
            340                 345                 350         


Val Ile Ser His His Ala Asp His Thr Leu Ser Ser Phe Cys Gln Trp 
        355                 360                 365             


Gln Ser Gly Leu Met Gly Lys Asp Gly Thr Arg His Asp His Ala Ile 
    370                 375                 380                 


Leu Leu Thr Gly Leu Asp Ile Cys Ser Trp Lys Asn Glu Pro Cys Asp 
385                 390                 395                 400 


Thr Leu Gly Phe Ala Pro Ile Ser Gly Met Cys Ser Lys Tyr Arg Ser 
                405                 410                 415     


Cys Thr Ile Asn Glu Asp Thr Gly Leu Gly Leu Ala Phe Thr Ile Ala 
            420                 425                 430         


His Glu Ser Gly His Asn Phe Gly Met Ile His Asp Gly Glu Gly Asn 
        435                 440                 445             


Met Cys Lys Lys Ser Glu Gly Asn Ile Met Ser Pro Thr Leu Ala Gly 
    450                 455                 460                 


Arg Asn Gly Val Phe Ser Trp Ser Pro Cys Ser Arg Gln Tyr Leu His 
465                 470                 475                 480 


Lys Phe Leu Ser Thr Ala Gln Ala Ile Cys Leu Ala Asp Gln Pro Lys 
                485                 490                 495     


Pro Val Lys Glu Tyr Lys Tyr Pro Glu Lys Leu Pro Gly Glu Leu Tyr 
            500                 505                 510         


Asp Ala Asn Thr Gln Cys Lys Trp Gln Phe Gly Glu Lys Ala Lys Leu 
        515                 520                 525             


Cys Met Leu Asp Phe Lys Lys Asp Ile Cys Lys Ala Leu Trp Cys His 
    530                 535                 540                 


Arg Ile Gly Arg Lys Cys Glu Thr Lys Phe Met Pro Ala Ala Glu Gly 
545                 550                 555                 560 


Thr Ile Cys Gly His Asp Met Val Arg Ser 
                565                 570 


<210>  341
<211>  1095
<212>  PRT
<213>  Homo Sapiens

<400>  341

Met Cys Asp Gly Ala Leu Leu Pro Pro Leu Val Leu Pro Val Leu Leu 
1               5                   10                  15      


Leu Leu Val Trp Gly Leu Asp Pro Gly Thr Ala Val Gly Asp Ala Ala 
            20                  25                  30          


Ala Asp Val Glu Val Val Leu Pro Trp Arg Val Arg Pro Asp Asp Val 
        35                  40                  45              


His Leu Pro Pro Leu Pro Ala Ala Pro Gly Pro Arg Arg Arg Arg Arg 
    50                  55                  60                  


Pro Arg Thr Pro Pro Ala Ala Pro Arg Ala Arg Pro Gly Glu Arg Ala 
65                  70                  75                  80  


Leu Leu Leu His Leu Pro Ala Phe Gly Arg Asp Leu Tyr Leu Gln Leu 
                85                  90                  95      


Arg Arg Asp Leu Arg Phe Leu Ser Arg Gly Phe Glu Val Glu Glu Ala 
            100                 105                 110         


Gly Ala Ala Arg Arg Arg Gly Arg Pro Ala Glu Leu Cys Phe Tyr Ser 
        115                 120                 125             


Gly Arg Val Leu Gly His Pro Gly Ser Leu Val Ser Leu Ser Ala Cys 
    130                 135                 140                 


Gly Ala Ala Gly Gly Leu Val Gly Leu Ile Gln Leu Gly Gln Glu Gln 
145                 150                 155                 160 


Val Leu Ile Gln Pro Leu Asn Asn Ser Gln Gly Pro Phe Ser Gly Arg 
                165                 170                 175     


Glu His Leu Ile Arg Arg Lys Trp Ser Leu Thr Pro Ser Pro Ser Ala 
            180                 185                 190         


Glu Ala Gln Arg Pro Glu Gln Leu Cys Lys Val Leu Thr Glu Lys Lys 
        195                 200                 205             


Lys Pro Thr Trp Gly Arg Pro Ser Arg Asp Trp Arg Glu Arg Arg Asn 
    210                 215                 220                 


Ala Ile Arg Leu Thr Ser Glu His Thr Val Glu Thr Leu Val Val Ala 
225                 230                 235                 240 


Asp Ala Asp Met Val Gln Tyr His Gly Ala Glu Ala Ala Gln Arg Phe 
                245                 250                 255     


Ile Leu Thr Val Met Asn Met Val Tyr Asn Met Phe Gln His Gln Ser 
            260                 265                 270         


Leu Gly Ile Lys Ile Asn Ile Gln Val Thr Lys Leu Val Leu Leu Arg 
        275                 280                 285             


Gln Arg Pro Ala Lys Leu Ser Ile Gly His His Gly Glu Arg Ser Leu 
    290                 295                 300                 


Glu Ser Phe Cys His Trp Gln Asn Glu Glu Tyr Gly Gly Ala Arg Tyr 
305                 310                 315                 320 


Leu Gly Asn Asn Gln Val Pro Gly Gly Lys Asp Asp Pro Pro Leu Val 
                325                 330                 335     


Asp Ala Ala Val Phe Val Thr Arg Thr Asp Phe Cys Val His Lys Asp 
            340                 345                 350         


Glu Pro Cys Asp Thr Val Gly Ile Ala Tyr Leu Gly Gly Val Cys Ser 
        355                 360                 365             


Ala Lys Arg Lys Cys Val Leu Ala Glu Asp Asn Gly Leu Asn Leu Ala 
    370                 375                 380                 


Phe Thr Ile Ala His Glu Leu Gly His Asn Leu Gly Met Asn His Asp 
385                 390                 395                 400 


Asp Asp His Ser Ser Cys Ala Gly Arg Ser His Ile Met Ser Gly Glu 
                405                 410                 415     


Trp Val Lys Gly Arg Asn Pro Ser Asp Leu Ser Trp Ser Ser Cys Ser 
            420                 425                 430         


Arg Asp Asp Leu Glu Asn Phe Leu Lys Ser Lys Val Ser Thr Cys Leu 
        435                 440                 445             


Leu Val Thr Asp Pro Arg Ser Gln His Thr Val Arg Leu Pro His Lys 
    450                 455                 460                 


Leu Pro Gly Met His Tyr Ser Ala Asn Glu Gln Cys Gln Ile Leu Phe 
465                 470                 475                 480 


Gly Met Asn Ala Thr Phe Cys Arg Asn Met Glu His Leu Met Cys Ala 
                485                 490                 495     


Gly Leu Trp Cys Leu Val Glu Gly Asp Thr Ser Cys Lys Thr Lys Leu 
            500                 505                 510         


Asp Pro Pro Leu Asp Gly Thr Glu Cys Gly Ala Asp Lys Trp Cys Arg 
        515                 520                 525             


Ala Gly Glu Cys Val Ser Lys Thr Pro Ile Pro Glu His Val Asp Gly 
    530                 535                 540                 


Asp Trp Ser Pro Trp Gly Ala Trp Ser Met Cys Ser Arg Thr Cys Gly 
545                 550                 555                 560 


Thr Gly Ala Arg Phe Arg Gln Arg Lys Cys Asp Asn Pro Pro Pro Gly 
                565                 570                 575     


Pro Gly Gly Thr His Cys Pro Gly Ala Ser Val Glu His Ala Val Cys 
            580                 585                 590         


Glu Asn Leu Pro Cys Pro Lys Gly Leu Pro Ser Phe Arg Asp Gln Gln 
        595                 600                 605             


Cys Gln Ala His Asp Arg Leu Ser Pro Lys Lys Lys Gly Leu Leu Thr 
    610                 615                 620                 


Ala Val Val Val Asp Asp Lys Pro Cys Glu Leu Tyr Cys Ser Pro Leu 
625                 630                 635                 640 


Gly Lys Glu Ser Pro Leu Leu Val Ala Asp Arg Val Leu Asp Gly Thr 
                645                 650                 655     


Pro Cys Gly Pro Tyr Glu Thr Asp Leu Cys Val His Gly Lys Cys Gln 
            660                 665                 670         


Lys Ile Gly Cys Asp Gly Ile Ile Gly Ser Ala Ala Lys Glu Asp Arg 
        675                 680                 685             


Cys Gly Val Cys Ser Gly Asp Gly Lys Thr Cys His Leu Val Lys Gly 
    690                 695                 700                 


Asp Phe Ser His Ala Arg Gly Thr Ala Leu Lys Asp Ser Gly Lys Gly 
705                 710                 715                 720 


Ser Ile Asn Ser Asp Trp Lys Ile Glu Leu Pro Gly Glu Phe Gln Ile 
                725                 730                 735     


Ala Gly Thr Thr Val Arg Tyr Val Arg Arg Gly Leu Trp Glu Lys Ile 
            740                 745                 750         


Ser Ala Lys Gly Pro Thr Lys Leu Pro Leu His Leu Met Val Leu Leu 
        755                 760                 765             


Phe His Asp Gln Asp Tyr Gly Ile His Tyr Glu Tyr Thr Val Pro Val 
    770                 775                 780                 


Asn Arg Thr Ala Glu Asn Gln Ser Glu Pro Glu Lys Pro Gln Asp Ser 
785                 790                 795                 800 


Leu Phe Ile Trp Thr His Ser Gly Trp Glu Gly Cys Ser Val Gln Cys 
                805                 810                 815     


Gly Gly Gly Glu Arg Arg Thr Ile Val Ser Cys Thr Arg Ile Val Asn 
            820                 825                 830         


Lys Thr Thr Thr Leu Val Asn Asp Ser Asp Cys Pro Gln Ala Ser Arg 
        835                 840                 845             


Pro Glu Pro Gln Val Arg Arg Cys Asn Leu His Pro Cys Gln Ser Arg 
    850                 855                 860                 


Trp Val Ala Gly Pro Trp Ser Pro Cys Ser Ala Thr Cys Glu Lys Gly 
865                 870                 875                 880 


Phe Gln His Arg Glu Val Thr Cys Val Tyr Gln Leu Gln Asn Gly Thr 
                885                 890                 895     


His Val Ala Thr Arg Pro Leu Tyr Cys Pro Gly Pro Arg Pro Ala Ala 
            900                 905                 910         


Val Gln Ser Cys Glu Gly Gln Asp Cys Leu Ser Ile Trp Glu Ala Ser 
        915                 920                 925             


Glu Trp Ser Gln Cys Ser Ala Ser Cys Gly Lys Gly Val Trp Lys Arg 
    930                 935                 940                 


Thr Val Ala Cys Thr Asn Ser Gln Gly Lys Cys Asp Ala Ser Thr Arg 
945                 950                 955                 960 


Pro Arg Ala Glu Glu Ala Cys Glu Asp Tyr Ser Gly Cys Tyr Glu Trp 
                965                 970                 975     


Lys Thr Gly Asp Trp Ser Thr Cys Ser Ser Thr Cys Gly Lys Gly Leu 
            980                 985                 990         


Gln Ser Arg Val Val Gln Cys Met  His Lys Val Thr Gly  Arg His Gly 
        995                 1000                 1005             


Ser Glu  Cys Pro Ala Leu Ser  Lys Pro Ala Pro Tyr  Arg Gln Cys 
    1010                 1015                 1020             


Tyr Gln  Glu Val Cys Asn Asp  Arg Ile Asn Ala Asn  Thr Ile Thr 
    1025                 1030                 1035             


Ser Pro  Arg Leu Ala Ala Leu  Thr Tyr Lys Cys Thr  Arg Asp Gln 
    1040                 1045                 1050             


Trp Thr  Val Tyr Cys Arg Val  Ile Arg Glu Lys Asn  Leu Cys Gln 
    1055                 1060                 1065             


Asp Met  Arg Trp Tyr Gln Arg  Cys Cys Gln Thr Cys  Arg Asp Phe 
    1070                 1075                 1080             


Tyr Ala  Asn Lys Met Arg Gln  Pro Pro Pro Asn Ser  
    1085                 1090                 1095 


<210>  342
<211>  68
<212>  PRT
<213>  Homo Sapiens

<400>  342

Met Cys Asp Gly Ala Leu Leu Pro Pro Leu Val Leu Pro Val Leu Leu 
1               5                   10                  15      


Leu Leu Val Trp Gly Leu Asp Pro Gly Thr Gly Trp Pro His Ser Ala 
            20                  25                  30          


Trp Ala Gly Ala Gly Ala Asn Pro Ala Pro Gln Gln Leu Pro Gly Pro 
        35                  40                  45              


Ile Gln Trp Thr Arg Thr Ser Asp Gln Ala Gln Met Val Leu Asp Pro 
    50                  55                  60                  


Gln Pro Phe Cys 
65              


<210>  343
<211>  214
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  343

Xaa Glu Leu Tyr Cys Ser Pro Leu Gly Lys Glu Ser Pro Leu Leu Val 
1               5                   10                  15      


Ala Asp Arg Val Leu Asp Gly Thr Pro Cys Gly Pro Tyr Glu Thr Asp 
            20                  25                  30          


Leu Cys Val His Gly Lys Cys Gln Lys Ile Gly Cys Asp Gly Ile Ile 
        35                  40                  45              


Gly Ser Ala Ala Lys Glu Asp Arg Cys Gly Val Cys Ser Gly Asp Gly 
    50                  55                  60                  


Lys Thr Cys His Leu Val Lys Gly Asp Phe Ser His Ala Arg Gly Thr 
65                  70                  75                  80  


Gly Tyr Ile Glu Ala Ala Val Ile Pro Ala Gly Ala Arg Arg Ile Arg 
                85                  90                  95      


Val Val Glu Asp Lys Pro Ala His Ser Phe Leu Ala Leu Lys Asp Ser 
            100                 105                 110         


Gly Lys Gly Ser Ile Asn Ser Asp Trp Lys Ile Glu Leu Pro Gly Glu 
        115                 120                 125             


Phe Gln Ile Ala Gly Thr Thr Val Arg Tyr Val Arg Arg Gly Leu Trp 
    130                 135                 140                 


Glu Lys Ile Ser Ala Lys Gly Pro Thr Lys Leu Pro Leu His Leu Met 
145                 150                 155                 160 


Val Leu Leu Phe His Asp Gln Asp Tyr Gly Ile His Tyr Glu Tyr Thr 
                165                 170                 175     


Val Pro Val Asn Arg Thr Ala Glu Asn Gln Ser Glu Pro Glu Lys Pro 
            180                 185                 190         


Gln Asp Ser Leu Phe Ile Trp Thr His Ser Gly Trp Glu Gly Cys Ser 
        195                 200                 205             


Val Gln Cys Gly Gly Gly 
    210                 


<210>  344
<211>  120
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  344

Xaa Gly Arg Pro Ala Glu Leu Cys Phe Tyr Ser Gly Arg Val Leu Gly 
1               5                   10                  15      


His Pro Gly Ser Leu Val Ser Leu Ser Ala Cys Gly Ala Ala Gly Gly 
            20                  25                  30          


Leu Val Gly Leu Ile Gln Leu Gly Gln Glu Gln Val Leu Ile Gln Pro 
        35                  40                  45              


Leu Asn Asn Ser Gln Gly Pro Phe Ser Gly Arg Glu His Leu Ile Arg 
    50                  55                  60                  


Arg Lys Trp Ser Leu Thr Pro Ser Pro Ser Ala Glu Ala Gln Arg Pro 
65                  70                  75                  80  


Glu Gln Leu Cys Lys Val Leu Thr Val Pro Gln Cys Leu Gly Leu Thr 
                85                  90                  95      


Trp Glu Asp Leu Lys Ser Gly Gly Trp Ser Asp Leu Glu Val Pro His 
            100                 105                 110         


Ser Cys Val Trp Pro Gly Gly Gly 
        115                 120 


<210>  345
<211>  1221
<212>  PRT
<213>  Homo Sapiens

<400>  345

Met Glu Cys Ala Leu Leu Leu Ala Cys Ala Phe Pro Ala Ala Gly Ser 
1               5                   10                  15      


Gly Pro Pro Arg Gly Leu Ala Gly Leu Gly Arg Val Ala Lys Ala Leu 
            20                  25                  30          


Gln Leu Cys Cys Leu Cys Cys Ala Ser Val Ala Ala Ala Leu Ala Ser 
        35                  40                  45              


Asp Ser Ser Ser Gly Ala Ser Gly Leu Asn Asp Asp Tyr Val Phe Val 
    50                  55                  60                  


Thr Pro Val Glu Val Asp Ser Ala Gly Ser Tyr Ile Ser His Asp Ile 
65                  70                  75                  80  


Leu His Asn Gly Arg Lys Lys Arg Ser Ala Gln Asn Ala Arg Ser Ser 
                85                  90                  95      


Leu His Tyr Arg Phe Ser Ala Phe Gly Gln Glu Leu His Leu Glu Leu 
            100                 105                 110         


Lys Pro Ser Ala Ile Leu Ser Ser His Phe Ile Val Gln Val Leu Gly 
        115                 120                 125             


Lys Asp Gly Ala Ser Glu Thr Gln Lys Pro Glu Val Gln Gln Cys Phe 
    130                 135                 140                 


Tyr Gln Gly Phe Ile Arg Asn Asp Ser Ser Ser Ser Val Ala Val Ser 
145                 150                 155                 160 


Thr Cys Ala Gly Leu Ser Gly Leu Ile Arg Thr Arg Lys Asn Glu Phe 
                165                 170                 175     


Leu Ile Ser Pro Leu Pro Gln Leu Leu Ala Gln Glu His Asn Tyr Ser 
            180                 185                 190         


Ser Pro Ala Gly His His Pro His Val Leu Tyr Lys Arg Thr Ala Glu 
        195                 200                 205             


Glu Lys Ile Gln Arg Tyr Arg Gly Tyr Pro Gly Ser Gly Arg Asn Tyr 
    210                 215                 220                 


Pro Gly Tyr Ser Pro Ser His Ile Pro His Ala Ser Gln Ser Arg Glu 
225                 230                 235                 240 


Thr Glu Tyr His His Arg Arg Leu Gln Lys Gln His Phe Cys Gly Arg 
                245                 250                 255     


Arg Lys Lys Tyr Ala Pro Lys Pro Pro Thr Glu Asp Thr Tyr Leu Arg 
            260                 265                 270         


Phe Asp Glu Tyr Gly Ser Ser Gly Arg Pro Arg Arg Ser Ala Gly Lys 
        275                 280                 285             


Ser Gln Lys Gly Leu Asn Val Glu Thr Leu Val Val Ala Asp Lys Lys 
    290                 295                 300                 


Met Val Glu Lys His Gly Lys Gly Asn Val Thr Thr Tyr Ile Leu Thr 
305                 310                 315                 320 


Val Met Asn Met Val Ser Gly Leu Phe Lys Asp Gly Thr Ile Gly Ser 
                325                 330                 335     


Asp Ile Asn Val Val Val Val Ser Leu Ile Leu Leu Glu Gln Glu Pro 
            340                 345                 350         


Gly Gly Leu Leu Ile Asn His His Ala Asp Gln Ser Leu Asn Ser Phe 
        355                 360                 365             


Cys Gln Trp Gln Ser Ala Leu Ile Gly Lys Asn Gly Lys Arg His Asp 
    370                 375                 380                 


His Ala Ile Leu Leu Thr Gly Phe Asp Ile Cys Ser Trp Lys Asn Glu 
385                 390                 395                 400 


Pro Cys Asp Thr Leu Gly Phe Ala Pro Ile Ser Gly Met Cys Ser Lys 
                405                 410                 415     


Tyr Arg Ser Cys Thr Ile Asn Glu Asp Thr Gly Leu Gly Leu Ala Phe 
            420                 425                 430         


Thr Ile Ala His Glu Ser Gly His Asn Phe Gly Met Ile His Asp Gly 
        435                 440                 445             


Glu Gly Asn Pro Cys Arg Lys Ala Glu Gly Asn Ile Met Ser Pro Thr 
    450                 455                 460                 


Leu Thr Gly Asn Asn Gly Val Phe Ser Trp Ser Ser Cys Ser Arg Gln 
465                 470                 475                 480 


Tyr Leu Lys Lys Phe Leu Ser Thr Pro Gln Ala Gly Cys Leu Val Asp 
                485                 490                 495     


Glu Pro Lys Gln Ala Gly Gln Tyr Lys Tyr Pro Asp Lys Leu Pro Gly 
            500                 505                 510         


Gln Ile Tyr Asp Ala Asp Thr Gln Cys Lys Trp Gln Phe Gly Ala Lys 
        515                 520                 525             


Ala Lys Leu Cys Ser Leu Gly Phe Val Lys Asp Ile Cys Lys Ser Leu 
    530                 535                 540                 


Trp Cys His Arg Val Gly His Arg Cys Glu Thr Lys Phe Met Pro Ala 
545                 550                 555                 560 


Ala Glu Gly Thr Val Cys Gly Leu Ser Met Trp Cys Arg Gln Gly Gln 
                565                 570                 575     


Cys Val Lys Phe Gly Glu Leu Gly Pro Arg Pro Ile His Gly Gln Trp 
            580                 585                 590         


Ser Ala Trp Ser Lys Trp Ser Glu Cys Ser Arg Thr Cys Gly Gly Gly 
        595                 600                 605             


Val Lys Phe Gln Glu Arg His Cys Asn Asn Pro Lys Pro Gln Tyr Gly 
    610                 615                 620                 


Gly Leu Phe Cys Pro Gly Ser Ser Arg Ile Tyr Gln Leu Cys Asn Ile 
625                 630                 635                 640 


Asn Pro Cys Asn Glu Asn Ser Leu Asp Phe Arg Ala Gln Gln Cys Ala 
                645                 650                 655     


Glu Tyr Asn Ser Lys Pro Phe Arg Gly Trp Phe Tyr Gln Trp Lys Pro 
            660                 665                 670         


Tyr Thr Lys Val Glu Glu Glu Asp Arg Cys Lys Leu Tyr Cys Lys Ala 
        675                 680                 685             


Glu Asn Phe Glu Phe Phe Phe Ala Met Ser Gly Lys Val Lys Asp Gly 
    690                 695                 700                 


Thr Pro Cys Ser Pro Asn Lys Asn Asp Val Cys Ile Asp Gly Val Cys 
705                 710                 715                 720 


Glu Leu Val Gly Cys Asp His Glu Leu Gly Ser Lys Ala Val Ser Asp 
                725                 730                 735     


Ala Cys Gly Val Cys Lys Gly Asp Asn Ser Thr Cys Lys Phe Tyr Lys 
            740                 745                 750         


Gly Leu Tyr Leu Asn Gln His Lys Ala Asn Glu Tyr Tyr Pro Val Val 
        755                 760                 765             


Leu Ile Pro Ala Gly Ala Arg Ser Ile Glu Ile Gln Glu Leu Gln Val 
    770                 775                 780                 


Ser Ser Ser Tyr Leu Ala Val Arg Ser Leu Ser Gln Lys Tyr Tyr Leu 
785                 790                 795                 800 


Thr Gly Gly Trp Ser Ile Asp Trp Pro Gly Glu Phe Pro Phe Ala Gly 
                805                 810                 815     


Thr Thr Phe Glu Tyr Gln Arg Ser Phe Asn Arg Pro Glu Arg Leu Tyr 
            820                 825                 830         


Ala Pro Gly Pro Thr Asn Glu Thr Leu Val Phe Glu Ile Leu Met Gln 
        835                 840                 845             


Gly Lys Asn Pro Gly Ile Ala Trp Lys Tyr Ala Leu Pro Lys Val Met 
    850                 855                 860                 


Asn Gly Thr Pro Pro Ala Thr Lys Arg Pro Ala Tyr Thr Trp Ser Ile 
865                 870                 875                 880 


Val Gln Ser Glu Cys Ser Val Ser Cys Gly Gly Gly Tyr Ile Asn Val 
                885                 890                 895     


Lys Ala Ile Cys Leu Arg Asp Gln Asn Thr Gln Val Asn Ser Ser Phe 
            900                 905                 910         


Cys Ser Ala Lys Thr Lys Pro Val Thr Glu Pro Lys Ile Cys Asn Ala 
        915                 920                 925             


Phe Ser Cys Pro Ala Tyr Trp Met Pro Gly Glu Trp Ser Thr Cys Ser 
    930                 935                 940                 


Lys Ala Cys Ala Gly Gly Gln Gln Ser Arg Lys Ile Gln Cys Val Gln 
945                 950                 955                 960 


Lys Lys Pro Phe Gln Lys Glu Glu Ala Val Leu His Ser Leu Cys Pro 
                965                 970                 975     


Val Ser Thr Pro Thr Gln Val Gln Ala Cys Asn Ser His Ala Cys Pro 
            980                 985                 990         


Pro Gln Trp Ser Leu Gly Pro Trp  Ser Gln Cys Ser Lys  Thr Cys Gly 
        995                 1000                 1005             


Arg Gly  Val Arg Lys Arg Glu  Leu Leu Cys Lys Gly  Ser Ala Ala 
    1010                 1015                 1020             


Glu Thr  Leu Pro Glu Ser Gln  Cys Thr Ser Leu Pro  Arg Pro Glu 
    1025                 1030                 1035             


Leu Gln  Glu Gly Cys Val Leu  Gly Arg Cys Pro Lys  Asn Ser Arg 
    1040                 1045                 1050             


Leu Gln  Trp Val Ala Ser Ser  Trp Ser Glu Cys Ser  Ala Thr Cys 
    1055                 1060                 1065             


Gly Leu  Gly Val Arg Lys Arg  Glu Met Lys Cys Ser  Glu Lys Gly 
    1070                 1075                 1080             


Phe Gln  Gly Lys Leu Ile Thr  Phe Pro Glu Arg Arg  Cys Arg Asn 
    1085                 1090                 1095             


Ile Lys  Lys Pro Asn Leu Asp  Leu Glu Glu Thr Cys  Asn Arg Arg 
    1100                 1105                 1110             


Ala Cys  Pro Ala His Pro Val  Tyr Asn Met Val Ala  Gly Trp Tyr 
    1115                 1120                 1125             


Ser Leu  Pro Trp Gln Gln Cys  Thr Val Thr Cys Gly  Gly Gly Val 
    1130                 1135                 1140             


Gln Thr  Arg Ser Val His Cys  Val Gln Gln Gly Arg  Pro Ser Ser 
    1145                 1150                 1155             


Ser Cys  Leu Leu His Gln Lys  Pro Pro Val Leu Arg  Ala Cys Asn 
    1160                 1165                 1170             


Thr Asn  Phe Cys Pro Ala Pro  Glu Lys Arg Glu Asp  Pro Ser Cys 
    1175                 1180                 1185             


Val Asp  Phe Phe Asn Trp Cys  His Leu Val Pro Gln  His Gly Val 
    1190                 1195                 1200             


Cys Asn  His Lys Phe Tyr Gly  Lys Gln Cys Cys Lys  Ser Cys Thr 
    1205                 1210                 1215             


Arg Lys  Ile 
    1220     


<210>  346
<211>  274
<212>  PRT
<213>  Homo Sapiens

<400>  346

Met Glu Cys Ala Leu Leu Leu Ala Cys Ala Phe Pro Ala Ala Gly Ser 
1               5                   10                  15      


Gly Pro Pro Arg Gly Leu Ala Gly Leu Gly Arg Val Ala Lys Ala Leu 
            20                  25                  30          


Gln Leu Cys Cys Leu Cys Cys Ala Ser Val Ala Ala Ala Leu Ala Ser 
        35                  40                  45              


Asp Ser Ser Ser Gly Ala Ser Gly Leu Asn Asp Asp Tyr Val Phe Val 
    50                  55                  60                  


Thr Pro Val Glu Val Asp Ser Ala Gly Ser Tyr Ile Ser His Asp Ile 
65                  70                  75                  80  


Leu His Asn Gly Arg Lys Lys Arg Ser Ala Gln Asn Ala Arg Ser Ser 
                85                  90                  95      


Leu His Tyr Arg Phe Ser Ala Phe Gly Gln Glu Leu His Leu Glu Leu 
            100                 105                 110         


Lys Pro Ser Ala Ile Leu Ser Ser His Phe Ile Val Gln Val Leu Gly 
        115                 120                 125             


Lys Asp Gly Ala Ser Glu Thr Gln Lys Pro Glu Val Gln Gln Cys Phe 
    130                 135                 140                 


Tyr Gln Gly Phe Ile Arg Asn Asp Ser Ser Ser Ser Val Ala Val Ser 
145                 150                 155                 160 


Thr Cys Ala Gly Leu Ser Gly Leu Ile Arg Thr Arg Lys Asn Glu Phe 
                165                 170                 175     


Leu Ile Ser Pro Leu Pro Gln Leu Leu Ala Gln Glu His Asn Tyr Ser 
            180                 185                 190         


Ser Pro Ala Gly His His Pro His Val Leu Tyr Lys Arg Thr Ala Glu 
        195                 200                 205             


Glu Lys Ile Gln Arg Tyr Arg Gly Tyr Pro Gly Ser Gly Arg Asn Tyr 
    210                 215                 220                 


Pro Gly Tyr Ser Pro Ser His Ile Pro His Ala Ser Gln Ser Arg Glu 
225                 230                 235                 240 


Thr Glu Tyr His His Arg Arg Leu Gln Lys Gln His Phe Cys Gly Arg 
                245                 250                 255     


Arg Lys Lys Cys Ile Cys Ser Gln Ala Ser His Arg Gly His Leu Ser 
            260                 265                 270         


Lys Val 
        


<210>  347
<211>  62
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  347

Xaa Gln Gly Arg Pro Ser Ser Ser Cys Leu Leu His Gln Lys Pro Pro 
1               5                   10                  15      


Val Leu Arg Ala Cys Asn Thr Asn Phe Cys Pro Ala Pro Glu Lys Arg 
            20                  25                  30          


Asp Ser Ala Gly Ser Gln Leu Pro Cys Cys Asp Gly Pro Gln Ala Val 
        35                  40                  45              


His Glu Glu Gly Leu Arg Phe Pro Asp Asn His Trp Ala Met 
    50                  55                  60          


<210>  348
<211>  186
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  348

Xaa Val Asp Ser Ala Gly Ser Tyr Ile Ser His Asp Ile Leu His Asn 
1               5                   10                  15      


Gly Arg Lys Lys Arg Ser Ala Gln Asn Ala Arg Ser Ser Leu His Tyr 
            20                  25                  30          


Arg Phe Ser Ala Phe Gly Gln Glu Leu His Leu Glu Leu Lys Pro Ser 
        35                  40                  45              


Ala Ile Leu Ser Ser His Phe Ile Val Gln Val Leu Gly Lys Asp Gly 
    50                  55                  60                  


Ala Ser Glu Thr Gln Lys Pro Glu Val Gln Gln Cys Phe Tyr Gln Gly 
65                  70                  75                  80  


Phe Ile Arg Asn Asp Ser Ser Ser Ser Val Ala Val Ser Thr Cys Ala 
                85                  90                  95      


Gly Leu Leu Leu Ala Gln Glu His Asn Tyr Ser Ser Pro Ala Gly His 
            100                 105                 110         


His Pro His Val Leu Tyr Lys Arg Thr Ala Glu Glu Lys Ile Gln Arg 
        115                 120                 125             


Tyr Arg Gly Tyr Pro Gly Ser Gly Arg Asn Tyr Pro Gly Tyr Ser Pro 
    130                 135                 140                 


Ser His Ile Pro His Ala Ser Gln Ser Arg Glu Thr Glu Tyr His His 
145                 150                 155                 160 


Arg Arg Leu Gln Lys Gln His Phe Cys Gly Arg Arg Lys Lys Cys Ile 
                165                 170                 175     


Cys Ser Gln Ala Ser His Arg Gly His Leu 
            180                 185     


<210>  349
<211>  37
<212>  PRT
<213>  Homo Sapiens

<400>  349

Met Gly Lys Asn Arg Glu Met Arg Leu Thr His Ile Cys Cys Cys Cys 
1               5                   10                  15      


Leu Leu Tyr Gln Leu Gly Phe Leu Ser Asn Gly Ile Val Ser Asp Gly 
            20                  25                  30          


Ile Tyr Thr Ala Gln 
        35          


<210>  350
<211>  1213
<212>  PRT
<213>  Homo Sapiens

<400>  350

Met Gly Lys Asn Arg Glu Met Arg Leu Thr His Ile Cys Cys Cys Cys 
1               5                   10                  15      


Leu Leu Tyr Gln Leu Gly Phe Leu Ser Asn Gly Ile Val Ser Glu Leu 
            20                  25                  30          


Gln Phe Ala Pro Asp Arg Glu Glu Trp Glu Val Val Phe Pro Ala Leu 
        35                  40                  45              


Trp Arg Arg Glu Pro Val Asp Pro Ala Gly Gly Ser Gly Gly Ser Ala 
    50                  55                  60                  


Asp Pro Gly Trp Val Arg Gly Val Gly Gly Gly Gly Ser Ala Arg Ala 
65                  70                  75                  80  


Gln Ala Ala Gly Ser Ser Arg Glu Val Arg Ser Val Ala Pro Val Pro 
                85                  90                  95      


Leu Glu Glu Pro Val Glu Gly Arg Ser Glu Ser Arg Leu Arg Pro Pro 
            100                 105                 110         


Pro Pro Ser Glu Gly Glu Glu Asp Glu Glu Leu Glu Ser Gln Glu Leu 
        115                 120                 125             


Pro Arg Gly Ser Ser Gly Ala Ala Ala Leu Ser Pro Gly Ala Pro Ala 
    130                 135                 140                 


Ser Trp Gln Pro Pro Pro Pro Pro Gln Pro Pro Pro Ser Pro Pro Pro 
145                 150                 155                 160 


Ala Gln His Ala Glu Pro Asp Gly Asp Glu Val Leu Leu Arg Ile Pro 
                165                 170                 175     


Ala Phe Ser Arg Asp Leu Tyr Leu Leu Leu Arg Arg Asp Gly Arg Phe 
            180                 185                 190         


Leu Ala Pro Arg Phe Ala Val Glu Gln Arg Pro Asn Pro Gly Pro Gly 
        195                 200                 205             


Pro Thr Gly Ala Ala Ser Ala Pro Gln Pro Pro Ala Pro Pro Asp Ala 
    210                 215                 220                 


Gly Cys Phe Tyr Thr Gly Ala Val Leu Arg His Pro Gly Ser Leu Ala 
225                 230                 235                 240 


Ser Phe Ser Thr Cys Gly Gly Gly Leu Met Gly Phe Ile Gln Leu Asn 
                245                 250                 255     


Glu Asp Phe Ile Phe Ile Glu Pro Leu Asn Asp Thr Met Ala Ile Thr 
            260                 265                 270         


Gly His Pro His Arg Val Tyr Arg Gln Lys Arg Ser Met Glu Glu Lys 
        275                 280                 285             


Val Thr Glu Lys Ser Ala Leu His Ser His Tyr Cys Gly Ile Ile Ser 
    290                 295                 300                 


Asp Lys Gly Arg Pro Arg Ser Arg Lys Ile Ala Glu Ser Gly Arg Gly 
305                 310                 315                 320 


Lys Arg Tyr Ser Tyr Lys Leu Pro Gln Glu Tyr Asn Ile Glu Thr Val 
                325                 330                 335     


Val Val Ala Asp Pro Ala Met Val Ser Tyr His Gly Ala Asp Ala Ala 
            340                 345                 350         


Arg Arg Phe Ile Leu Thr Ile Leu Asn Met Val Phe Asn Leu Phe Gln 
        355                 360                 365             


His Lys Ser Leu Ser Val Gln Val Asn Leu Arg Val Ile Lys Leu Ile 
    370                 375                 380                 


Leu Leu His Glu Thr Pro Pro Glu Leu Tyr Ile Gly His His Gly Glu 
385                 390                 395                 400 


Lys Met Leu Glu Ser Phe Cys Lys Trp Gln His Glu Glu Phe Gly Lys 
                405                 410                 415     


Lys Asn Asp Ile His Leu Glu Met Ser Thr Asn Trp Gly Glu Asp Met 
            420                 425                 430         


Thr Ser Val Asp Ala Ala Ile Leu Ile Thr Arg Lys Asp Phe Cys Val 
        435                 440                 445             


His Lys Asp Glu Pro Cys Asp Thr Val Gly Ile Ala Tyr Leu Ser Gly 
    450                 455                 460                 


Met Cys Ser Glu Lys Arg Lys Cys Ile Ile Ala Glu Asp Asn Gly Leu 
465                 470                 475                 480 


Asn Leu Ala Phe Thr Ile Ala His Glu Met Gly His Asn Met Gly Ile 
                485                 490                 495     


Asn His Asp Asn Asp His Pro Ser Cys Ala Asp Gly Leu His Ile Met 
            500                 505                 510         


Ser Gly Glu Trp Ile Lys Gly Gln Asn Leu Gly Asp Val Ser Trp Ser 
        515                 520                 525             


Arg Cys Ser Lys Glu Asp Leu Glu Arg Phe Leu Arg Ser Lys Ala Ser 
    530                 535                 540                 


Asn Cys Leu Leu Gln Thr Asn Pro Gln Ser Val Asn Ser Val Met Val 
545                 550                 555                 560 


Pro Ser Lys Leu Pro Gly Met Thr Tyr Thr Ala Asp Glu Gln Cys Gln 
                565                 570                 575     


Ile Leu Phe Gly Pro Leu Ala Ser Phe Cys Gln Glu Met Gln His Val 
            580                 585                 590         


Ile Cys Thr Gly Leu Trp Cys Lys Val Glu Gly Glu Lys Glu Cys Arg 
        595                 600                 605             


Thr Lys Leu Asp Pro Pro Met Asp Gly Thr Asp Cys Asp Leu Gly Lys 
    610                 615                 620                 


Trp Cys Lys Ala Gly Glu Cys Thr Ser Arg Thr Ser Ala Pro Glu His 
625                 630                 635                 640 


Leu Ala Gly Glu Trp Ser Leu Trp Ser Pro Cys Ser Arg Thr Cys Ser 
                645                 650                 655     


Ala Gly Ile Ser Ser Arg Glu Arg Lys Cys Pro Gly Leu Asp Ser Glu 
            660                 665                 670         


Ala Arg Asp Cys Asn Gly Pro Arg Lys Gln Tyr Arg Ile Cys Glu Asn 
        675                 680                 685             


Pro Pro Cys Pro Ala Gly Leu Pro Gly Phe Arg Asp Trp Gln Cys Gln 
    690                 695                 700                 


Ala Tyr Ser Val Arg Thr Ser Ser Pro Lys His Ile Leu Gln Trp Gln 
705                 710                 715                 720 


Ala Val Leu Asp Glu Glu Lys Pro Cys Ala Leu Phe Cys Ser Pro Val 
                725                 730                 735     


Gly Lys Glu Gln Pro Ile Leu Leu Ser Glu Lys Val Met Asp Gly Thr 
            740                 745                 750         


Ser Cys Gly Tyr Gln Gly Leu Asp Ile Cys Ala Asn Gly Arg Cys Gln 
        755                 760                 765             


Lys Val Gly Cys Asp Gly Leu Leu Gly Ser Leu Ala Arg Glu Asp His 
    770                 775                 780                 


Cys Gly Val Cys Asn Gly Asn Gly Lys Ser Cys Lys Ile Ile Lys Gly 
785                 790                 795                 800 


Asp Phe Asn His Thr Arg Gly Ala Gly Tyr Val Glu Val Leu Val Ile 
                805                 810                 815     


Pro Ala Gly Ala Arg Arg Ile Lys Val Val Glu Glu Lys Pro Ala His 
            820                 825                 830         


Ser Tyr Leu Ala Leu Arg Asp Ala Gly Lys Gln Ser Ile Asn Ser Asp 
        835                 840                 845             


Trp Lys Ile Glu His Ser Gly Ala Phe Asn Leu Ala Gly Thr Thr Val 
    850                 855                 860                 


His Tyr Val Arg Arg Gly Leu Trp Glu Lys Ile Ser Ala Lys Gly Pro 
865                 870                 875                 880 


Thr Thr Ala Pro Leu His Leu Leu Val Leu Leu Phe Gln Asp Gln Asn 
                885                 890                 895     


Tyr Gly Leu His Tyr Glu Tyr Thr Ile Pro Ser Asp Pro Leu Pro Glu 
            900                 905                 910         


Asn Gln Ser Ser Lys Ala Pro Glu Pro Leu Phe Met Trp Thr His Thr 
        915                 920                 925             


Ser Trp Glu Asp Cys Asp Ala Thr Cys Gly Gly Gly Glu Arg Lys Thr 
    930                 935                 940                 


Thr Val Ser Cys Thr Lys Ile Met Ser Lys Asn Ile Ser Ile Val Asp 
945                 950                 955                 960 


Asn Glu Lys Cys Lys Tyr Leu Thr Lys Pro Glu Pro Gln Ile Arg Lys 
                965                 970                 975     


Cys Asn Glu Gln Pro Cys Gln Thr Arg Trp Met Met Thr Glu Trp Thr 
            980                 985                 990         


Pro Cys Ser Arg Thr Cys Gly Lys  Gly Met Gln Ser Arg  Gln Val Ala 
        995                 1000                 1005             


Cys Thr  Gln Gln Leu Ser Asn  Gly Thr Leu Ile Arg  Ala Arg Glu 
    1010                 1015                 1020             


Arg Asp  Cys Ile Gly Pro Lys  Pro Ala Ser Ala Gln  Arg Cys Glu 
    1025                 1030                 1035             


Gly Gln  Asp Cys Met Thr Val  Trp Glu Ala Gly Val  Trp Ser Glu 
    1040                 1045                 1050             


Cys Ser  Val Lys Cys Gly Lys  Gly Ile Arg His Arg  Thr Val Arg 
    1055                 1060                 1065             


Cys Thr  Asn Pro Arg Lys Lys  Cys Val Leu Ser Thr  Arg Pro Arg 
    1070                 1075                 1080             


Glu Ala  Glu Asp Cys Glu Asp  Tyr Ser Lys Cys Tyr  Val Trp Arg 
    1085                 1090                 1095             


Met Gly  Asp Trp Ser Lys Cys  Ser Ile Thr Cys Gly  Lys Gly Met 
    1100                 1105                 1110             


Gln Ser  Arg Val Ile Gln Cys  Met His Lys Ile Thr  Gly Arg His 
    1115                 1120                 1125             


Gly Asn  Glu Cys Phe Ser Ser  Glu Lys Pro Ala Ala  Tyr Arg Pro 
    1130                 1135                 1140             


Cys His  Leu Gln Pro Cys Asn  Glu Lys Ile Asn Val  Asn Thr Ile 
    1145                 1150                 1155             


Thr Ser  Pro Arg Leu Ala Ala  Leu Thr Phe Lys Cys  Leu Gly Asp 
    1160                 1165                 1170             


Gln Trp  Pro Val Tyr Cys Arg  Val Ile Arg Glu Lys  Asn Leu Cys 
    1175                 1180                 1185             


Gln Asp  Met Arg Trp Tyr Gln  Arg Cys Cys Glu Thr  Cys Arg Asp 
    1190                 1195                 1200             


Phe Tyr  Ala Gln Lys Leu Gln  Gln Lys Ser 
    1205                 1210             


<210>  351
<211>  1207
<212>  PRT
<213>  Homo Sapiens

<400>  351

Met Arg Leu Thr His Ile Cys Cys Cys Cys Leu Leu Tyr Gln Leu Gly 
1               5                   10                  15      


Phe Leu Ser Asn Gly Ile Val Ser Glu Leu Gln Phe Ala Pro Asp Arg 
            20                  25                  30          


Glu Glu Trp Glu Val Val Phe Pro Ala Leu Trp Arg Arg Glu Pro Val 
        35                  40                  45              


Asp Pro Ala Gly Gly Ser Gly Gly Ser Ala Asp Pro Gly Trp Val Arg 
    50                  55                  60                  


Gly Val Gly Gly Gly Gly Ser Ala Arg Ala Gln Ala Ala Gly Ser Ser 
65                  70                  75                  80  


Arg Glu Val Arg Ser Val Ala Pro Val Pro Leu Glu Glu Pro Val Glu 
                85                  90                  95      


Gly Arg Ser Glu Ser Arg Leu Arg Pro Pro Pro Pro Ser Glu Gly Glu 
            100                 105                 110         


Glu Asp Glu Glu Leu Glu Ser Gln Glu Leu Pro Arg Gly Ser Ser Gly 
        115                 120                 125             


Ala Ala Ala Leu Ser Pro Gly Ala Pro Ala Ser Trp Gln Pro Pro Pro 
    130                 135                 140                 


Pro Pro Gln Pro Pro Pro Ser Pro Pro Pro Ala Gln His Ala Glu Pro 
145                 150                 155                 160 


Asp Gly Asp Glu Val Leu Leu Arg Ile Pro Ala Phe Ser Arg Asp Leu 
                165                 170                 175     


Tyr Leu Leu Leu Arg Arg Asp Gly Arg Phe Leu Ala Pro Arg Phe Ala 
            180                 185                 190         


Val Glu Gln Arg Pro Asn Pro Gly Pro Gly Pro Thr Gly Ala Ala Ser 
        195                 200                 205             


Ala Pro Gln Pro Pro Ala Pro Pro Asp Ala Gly Cys Phe Tyr Thr Gly 
    210                 215                 220                 


Ala Val Leu Arg His Pro Gly Ser Leu Ala Ser Phe Ser Thr Cys Gly 
225                 230                 235                 240 


Gly Gly Leu Met Gly Phe Ile Gln Leu Asn Glu Asp Phe Ile Phe Ile 
                245                 250                 255     


Glu Pro Leu Asn Asp Thr Met Ala Ile Thr Gly His Pro His Arg Val 
            260                 265                 270         


Tyr Arg Gln Lys Arg Ser Met Glu Glu Lys Val Thr Glu Lys Ser Ala 
        275                 280                 285             


Leu His Ser His Tyr Cys Gly Ile Ile Ser Asp Lys Gly Arg Pro Arg 
    290                 295                 300                 


Ser Arg Lys Ile Ala Glu Ser Gly Arg Gly Lys Arg Tyr Ser Tyr Lys 
305                 310                 315                 320 


Leu Pro Gln Glu Tyr Asn Ile Glu Thr Val Val Val Ala Asp Pro Ala 
                325                 330                 335     


Met Val Ser Tyr His Gly Ala Asp Ala Ala Arg Arg Phe Ile Leu Thr 
            340                 345                 350         


Ile Leu Asn Met Val Phe Asn Leu Phe Gln His Lys Ser Leu Ser Val 
        355                 360                 365             


Gln Val Asn Leu Arg Val Ile Lys Leu Ile Leu Leu His Glu Thr Pro 
    370                 375                 380                 


Pro Glu Leu Tyr Ile Gly His His Gly Glu Lys Met Leu Glu Ser Phe 
385                 390                 395                 400 


Cys Lys Trp Gln His Glu Glu Phe Gly Lys Lys Asn Asp Ile His Leu 
                405                 410                 415     


Glu Met Ser Thr Asn Trp Gly Glu Asp Met Thr Ser Val Asp Ala Ala 
            420                 425                 430         


Ile Leu Ile Thr Arg Lys Asp Phe Cys Val His Lys Asp Glu Pro Cys 
        435                 440                 445             


Asp Thr Val Gly Ile Ala Tyr Leu Ser Gly Met Cys Ser Glu Lys Arg 
    450                 455                 460                 


Lys Cys Ile Ile Ala Glu Asp Asn Gly Leu Asn Leu Ala Phe Thr Ile 
465                 470                 475                 480 


Ala His Glu Met Gly His Asn Met Gly Ile Asn His Asp Asn Asp His 
                485                 490                 495     


Pro Ser Cys Ala Asp Gly Leu His Ile Met Ser Gly Glu Trp Ile Lys 
            500                 505                 510         


Gly Gln Asn Leu Gly Asp Val Ser Trp Ser Arg Cys Ser Lys Glu Asp 
        515                 520                 525             


Leu Glu Arg Phe Leu Arg Ser Lys Ala Ser Asn Cys Leu Leu Gln Thr 
    530                 535                 540                 


Asn Pro Gln Ser Val Asn Ser Val Met Val Pro Ser Lys Leu Pro Gly 
545                 550                 555                 560 


Met Thr Tyr Thr Ala Asp Glu Gln Cys Gln Ile Leu Phe Gly Pro Leu 
                565                 570                 575     


Ala Ser Phe Cys Gln Glu Met Gln His Val Ile Cys Thr Gly Leu Trp 
            580                 585                 590         


Cys Lys Val Glu Gly Glu Lys Glu Cys Arg Thr Lys Leu Asp Pro Pro 
        595                 600                 605             


Met Asp Gly Thr Asp Cys Asp Leu Gly Lys Trp Cys Lys Ala Gly Glu 
    610                 615                 620                 


Cys Thr Ser Arg Thr Ser Ala Pro Glu His Leu Ala Gly Glu Trp Ser 
625                 630                 635                 640 


Leu Trp Ser Pro Cys Ser Arg Thr Cys Ser Ala Gly Ile Ser Ser Arg 
                645                 650                 655     


Glu Arg Lys Cys Pro Gly Leu Asp Ser Glu Ala Arg Asp Cys Asn Gly 
            660                 665                 670         


Pro Arg Lys Gln Tyr Arg Ile Cys Glu Asn Pro Pro Cys Pro Ala Gly 
        675                 680                 685             


Leu Pro Gly Phe Arg Asp Trp Gln Cys Gln Ala Tyr Ser Val Arg Thr 
    690                 695                 700                 


Ser Ser Pro Lys His Ile Leu Gln Trp Gln Ala Val Leu Asp Glu Glu 
705                 710                 715                 720 


Lys Pro Cys Ala Leu Phe Cys Ser Pro Val Gly Lys Glu Gln Pro Ile 
                725                 730                 735     


Leu Leu Ser Glu Lys Val Met Asp Gly Thr Ser Cys Gly Tyr Gln Gly 
            740                 745                 750         


Leu Asp Ile Cys Ala Asn Gly Arg Cys Gln Lys Val Gly Cys Asp Gly 
        755                 760                 765             


Leu Leu Gly Ser Leu Ala Arg Glu Asp His Cys Gly Val Cys Asn Gly 
    770                 775                 780                 


Asn Gly Lys Ser Cys Lys Ile Ile Lys Gly Asp Phe Asn His Thr Arg 
785                 790                 795                 800 


Gly Ala Gly Tyr Val Glu Val Leu Val Ile Pro Ala Gly Ala Arg Arg 
                805                 810                 815     


Ile Lys Val Val Glu Glu Lys Pro Ala His Ser Tyr Leu Ala Leu Arg 
            820                 825                 830         


Asp Ala Gly Lys Gln Ser Ile Asn Ser Asp Trp Lys Ile Glu His Ser 
        835                 840                 845             


Gly Ala Phe Asn Leu Ala Gly Thr Thr Val His Tyr Val Arg Arg Gly 
    850                 855                 860                 


Leu Trp Glu Lys Ile Ser Ala Lys Gly Pro Thr Thr Ala Pro Leu His 
865                 870                 875                 880 


Leu Leu Val Leu Leu Phe Gln Asp Gln Asn Tyr Gly Leu His Tyr Glu 
                885                 890                 895     


Tyr Thr Ile Pro Ser Asp Pro Leu Pro Glu Asn Gln Ser Ser Lys Ala 
            900                 905                 910         


Pro Glu Pro Leu Phe Met Trp Thr His Thr Ser Trp Glu Asp Cys Asp 
        915                 920                 925             


Ala Thr Cys Gly Gly Gly Glu Arg Lys Thr Thr Val Ser Cys Thr Lys 
    930                 935                 940                 


Ile Met Ser Lys Asn Ile Ser Ile Val Asp Asn Glu Lys Cys Lys Tyr 
945                 950                 955                 960 


Leu Thr Lys Pro Glu Pro Gln Ile Arg Lys Cys Asn Glu Gln Pro Cys 
                965                 970                 975     


Gln Thr Arg Trp Met Met Thr Glu Trp Thr Pro Cys Ser Arg Thr Cys 
            980                 985                 990         


Gly Lys Gly Met Gln Ser Arg Gln  Val Ala Cys Thr Gln  Gln Leu Ser 
        995                 1000                 1005             


Asn Gly  Thr Leu Ile Arg Ala  Arg Glu Arg Asp Cys  Ile Gly Pro 
    1010                 1015                 1020             


Lys Pro  Ala Ser Ala Gln Arg  Cys Glu Gly Gln Asp  Cys Met Thr 
    1025                 1030                 1035             


Val Trp  Glu Ala Gly Val Trp  Ser Glu Cys Ser Val  Lys Cys Gly 
    1040                 1045                 1050             


Lys Gly  Ile Arg His Arg Thr  Val Arg Cys Thr Asn  Pro Arg Lys 
    1055                 1060                 1065             


Lys Cys  Val Leu Ser Thr Arg  Pro Arg Glu Ala Glu  Asp Cys Glu 
    1070                 1075                 1080             


Asp Tyr  Ser Lys Cys Tyr Val  Trp Arg Met Gly Asp  Trp Ser Lys 
    1085                 1090                 1095             


Cys Ser  Ile Thr Cys Gly Lys  Gly Met Gln Ser Arg  Val Ile Gln 
    1100                 1105                 1110             


Cys Met  His Lys Ile Thr Gly  Arg His Gly Asn Glu  Cys Phe Ser 
    1115                 1120                 1125             


Ser Glu  Lys Pro Ala Ala Tyr  Arg Pro Cys His Leu  Gln Pro Cys 
    1130                 1135                 1140             


Asn Glu  Lys Ile Asn Val Asn  Thr Ile Thr Ser Pro  Arg Leu Ala 
    1145                 1150                 1155             


Ala Leu  Thr Phe Lys Cys Leu  Gly Asp Gln Trp Pro  Val Tyr Cys 
    1160                 1165                 1170             


Arg Val  Ile Arg Glu Lys Asn  Leu Cys Gln Asp Met  Arg Trp Tyr 
    1175                 1180                 1185             


Gln Arg  Cys Cys Glu Thr Cys  Arg Asp Phe Tyr Ala  Gln Lys Leu 
    1190                 1195                 1200             


Gln Gln  Lys Ser 
    1205         


<210>  352
<211>  145
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  352

Xaa Asp Ala Gly Cys Phe Tyr Thr Gly Ala Val Leu Arg His Pro Gly 
1               5                   10                  15      


Ser Leu Ala Ser Phe Ser Thr Cys Gly Gly Gly Leu Met Gly Phe Ile 
            20                  25                  30          


Gln Leu Asn Glu Asp Phe Ile Phe Ile Glu Pro Leu Asn Asp Thr Met 
        35                  40                  45              


Ala Ile Thr Gly His Pro His Arg Val Tyr Arg Gln Lys Arg Ser Met 
    50                  55                  60                  


Glu Glu Lys Val Thr Glu Lys Ser Ala Leu His Ser His Tyr Cys Gly 
65                  70                  75                  80  


Ile Ile Ser Asp Lys Gly Arg Pro Arg Ser Arg Lys Ile Ala Glu Ser 
                85                  90                  95      


Gly Arg Gly Lys Arg Tyr Ser Tyr Lys Leu Pro Gln Glu Tyr Asn Ile 
            100                 105                 110         


Glu Thr Val Val Val Ala Asp Pro Ala Met Val Ser Tyr His Gly Ala 
        115                 120                 125             


Asp Ala Ala Arg Arg Phe Ile Leu Thr Ile Leu Asn Met Val Gly Lys 
    130                 135                 140                 


Leu 
145 


<210>  353
<211>  1211
<212>  PRT
<213>  Homo Sapiens

<400>  353

Met Asp Pro Pro Ala Gly Ala Ala Arg Arg Leu Leu Cys Pro Ala Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Pro Pro Pro Leu Leu Pro Pro Pro Pro 
            20                  25                  30          


Pro Pro Ala Asn Ala Arg Leu Ala Ala Ala Ala Asp Pro Pro Gly Gly 
        35                  40                  45              


Pro Leu Gly His Gly Ala Glu Arg Ile Leu Ala Val Pro Val Arg Thr 
    50                  55                  60                  


Asp Ala Gln Gly Arg Leu Val Ser His Val Val Ser Ala Ala Thr Ser 
65                  70                  75                  80  


Arg Ala Gly Val Arg Ala Arg Arg Ala Ala Pro Val Arg Thr Pro Ser 
                85                  90                  95      


Phe Pro Gly Gly Asn Glu Glu Glu Pro Gly Ser His Leu Phe Tyr Asn 
            100                 105                 110         


Val Thr Val Phe Gly Arg Asp Leu His Leu Arg Leu Arg Pro Asn Ala 
        115                 120                 125             


Arg Leu Val Ala Pro Gly Ala Thr Met Glu Trp Gln Gly Glu Lys Gly 
    130                 135                 140                 


Thr Thr Arg Val Glu Pro Leu Leu Gly Ser Cys Leu Tyr Val Gly Asp 
145                 150                 155                 160 


Val Ala Gly Leu Ala Glu Ala Ser Ser Val Ala Leu Ser Asn Cys Asp 
                165                 170                 175     


Gly Leu Ala Gly Leu Ile Arg Met Glu Glu Glu Glu Phe Phe Ile Glu 
            180                 185                 190         


Pro Leu Glu Lys Gly Leu Ala Ala Gln Glu Ala Glu Gln Gly Arg Val 
        195                 200                 205             


His Val Val Tyr Arg Arg Pro Pro Thr Ser Pro Pro Leu Gly Gly Pro 
    210                 215                 220                 


Gln Ala Leu Asp Thr Gly Ala Ser Leu Asp Ser Leu Asp Ser Leu Ser 
225                 230                 235                 240 


Arg Ala Leu Gly Val Leu Glu Glu His Ala Asn Ser Ser Arg Arg Arg 
                245                 250                 255     


Ala Arg Arg His Ala Ala Asp Asp Asp Tyr Asn Ile Glu Val Leu Leu 
            260                 265                 270         


Gly Val Asp Asp Ser Val Val Gln Phe His Gly Lys Glu His Val Gln 
        275                 280                 285             


Lys Tyr Leu Leu Thr Leu Met Asn Ile Val Asn Glu Ile Tyr His Asp 
    290                 295                 300                 


Glu Ser Leu Gly Ala His Ile Asn Val Val Leu Val Arg Ile Ile Leu 
305                 310                 315                 320 


Leu Ser Tyr Gly Lys Ser Met Ser Leu Ile Glu Ile Gly Asn Pro Ser 
                325                 330                 335     


Gln Ser Leu Glu Asn Val Cys Arg Trp Ala Tyr Leu Gln Gln Lys Pro 
            340                 345                 350         


Asp Thr Gly His Asp Glu Tyr His Asp His Ala Ile Phe Leu Thr Arg 
        355                 360                 365             


Gln Asp Phe Gly Pro Ser Gly Met Gln Gly Tyr Ala Pro Val Thr Gly 
    370                 375                 380                 


Met Cys His Pro Val Arg Ser Cys Thr Leu Asn His Glu Asp Gly Phe 
385                 390                 395                 400 


Ser Ser Ala Phe Val Val Ala His Glu Thr Gly His Val Leu Gly Met 
                405                 410                 415     


Glu His Asp Gly Gln Gly Asn Arg Cys Gly Asp Glu Val Arg Leu Gly 
            420                 425                 430         


Ser Ile Met Ala Pro Leu Val Gln Ala Ala Phe His Arg Phe His Trp 
        435                 440                 445             


Ser Arg Cys Ser Gln Gln Glu Leu Ser Arg Tyr Leu His Ser Tyr Asp 
    450                 455                 460                 


Cys Leu Leu Asp Asp Pro Phe Ala His Asp Trp Pro Ala Leu Pro Gln 
465                 470                 475                 480 


Leu Pro Gly Leu His Tyr Ser Met Asn Glu Gln Cys Arg Phe Asp Phe 
                485                 490                 495     


Gly Leu Gly Tyr Met Met Cys Thr Ala Phe Arg Thr Phe Asp Pro Cys 
            500                 505                 510         


Lys Gln Leu Trp Cys Ser His Pro Asp Asn Pro Tyr Phe Cys Lys Thr 
        515                 520                 525             


Lys Lys Gly Pro Pro Leu Asp Gly Thr Met Cys Ala Pro Gly Lys His 
    530                 535                 540                 


Cys Phe Lys Gly His Cys Ile Trp Leu Thr Pro Asp Ile Leu Lys Arg 
545                 550                 555                 560 


Asp Gly Ser Trp Gly Ala Trp Ser Pro Phe Gly Ser Cys Ser Arg Thr 
                565                 570                 575     


Cys Gly Thr Gly Val Lys Phe Arg Thr Arg Gln Cys Asp Asn Pro His 
            580                 585                 590         


Pro Ala Asn Gly Gly Arg Thr Cys Ser Gly Leu Ala Tyr Asp Phe Gln 
        595                 600                 605             


Leu Cys Ser Arg Gln Asp Cys Pro Asp Ser Leu Ala Asp Phe Arg Glu 
    610                 615                 620                 


Glu Gln Cys Arg Gln Trp Asp Leu Tyr Phe Glu His Gly Asp Ala Gln 
625                 630                 635                 640 


His His Trp Leu Pro His Glu His Arg Asp Ala Lys Glu Arg Cys His 
                645                 650                 655     


Leu Tyr Cys Glu Ser Arg Glu Thr Gly Glu Val Val Ser Met Lys Arg 
            660                 665                 670         


Met Val His Asp Gly Thr Arg Cys Ser Tyr Lys Asp Ala Phe Ser Leu 
        675                 680                 685             


Cys Val Arg Gly Asp Cys Arg Lys Val Gly Cys Asp Gly Val Ile Gly 
    690                 695                 700                 


Ser Ser Lys Gln Glu Asp Lys Cys Gly Val Cys Gly Gly Asp Asn Ser 
705                 710                 715                 720 


His Cys Lys Val Val Lys Gly Thr Phe Thr Arg Ser Pro Lys Lys His 
                725                 730                 735     


Gly Tyr Ile Lys Met Phe Glu Ile Pro Ala Gly Ala Arg His Leu Leu 
            740                 745                 750         


Ile Gln Glu Val Asp Ala Thr Ser His His Leu Ala Val Lys Asn Leu 
        755                 760                 765             


Glu Thr Gly Lys Phe Ile Leu Asn Glu Glu Asn Asp Val Asp Ala Ser 
    770                 775                 780                 


Ser Lys Thr Phe Ile Ala Met Gly Val Glu Trp Glu Tyr Arg Asp Glu 
785                 790                 795                 800 


Asp Gly Arg Glu Thr Leu Gln Thr Met Gly Pro Leu His Gly Thr Ile 
                805                 810                 815     


Thr Val Leu Val Ile Pro Val Gly Asp Thr Arg Val Ser Leu Thr Tyr 
            820                 825                 830         


Lys Tyr Met Ile His Glu Asp Ser Leu Asn Val Asp Asp Asn Asn Val 
        835                 840                 845             


Leu Glu Glu Asp Ser Val Val Tyr Glu Trp Ala Leu Lys Lys Trp Ser 
    850                 855                 860                 


Pro Cys Ser Lys Pro Cys Gly Gly Gly Ser Gln Phe Thr Lys Tyr Gly 
865                 870                 875                 880 


Cys Arg Arg Arg Leu Asp His Lys Met Val His Arg Gly Phe Cys Ala 
                885                 890                 895     


Ala Leu Ser Lys Pro Lys Ala Ile Arg Arg Ala Cys Asn Pro Gln Glu 
            900                 905                 910         


Cys Ser Gln Pro Val Trp Val Thr Gly Glu Trp Glu Pro Cys Ser Gln 
        915                 920                 925             


Thr Cys Gly Arg Thr Gly Met Gln Val Arg Ser Val Arg Cys Ile Gln 
    930                 935                 940                 


Pro Leu His Asp Asn Thr Thr Arg Ser Val His Ala Lys His Cys Asn 
945                 950                 955                 960 


Asp Ala Arg Pro Glu Ser Arg Arg Ala Cys Ser Arg Glu Leu Cys Pro 
                965                 970                 975     


Gly Arg Trp Arg Ala Gly Pro Trp Ser Gln Cys Ser Val Thr Cys Gly 
            980                 985                 990         


Asn Gly Thr Gln Glu Arg Pro Val  Leu Cys Arg Thr Ala  Asp Asp Ser 
        995                 1000                 1005             


Phe Gly  Ile Cys Gln Glu Glu  Arg Pro Glu Thr Ala  Arg Thr Cys 
    1010                 1015                 1020             


Arg Leu  Gly Pro Cys Pro Arg  Asn Ile Ser Asp Pro  Ser Lys Lys 
    1025                 1030                 1035             


Ser Tyr  Val Val Gln Trp Leu  Ser Arg Pro Asp Pro  Asp Ser Pro 
    1040                 1045                 1050             


Ile Arg  Lys Ile Ser Ser Lys  Gly His Cys Gln Gly  Asp Lys Ser 
    1055                 1060                 1065             


Ile Phe  Cys Arg Met Glu Val  Leu Ser Arg Tyr Cys  Ser Ile Pro 
    1070                 1075                 1080             


Gly Tyr  Asn Lys Leu Cys Cys  Lys Ser Cys Asn Leu  Tyr Asn Asn 
    1085                 1090                 1095             


Leu Thr  Asn Val Glu Gly Arg  Ile Glu Pro Pro Pro  Gly Lys His 
    1100                 1105                 1110             


Asn Asp  Ile Asp Val Phe Met  Pro Thr Leu Pro Val  Pro Thr Val 
    1115                 1120                 1125             


Ala Met  Glu Val Arg Pro Ser  Pro Ser Thr Pro Leu  Glu Val Pro 
    1130                 1135                 1140             


Leu Asn  Ala Ser Ser Thr Asn  Ala Thr Glu Asp His  Pro Glu Thr 
    1145                 1150                 1155             


Asn Ala  Val Asp Glu Pro Tyr  Lys Ile His Gly Leu  Glu Asp Glu 
    1160                 1165                 1170             


Val Gln  Pro Pro Asn Leu Ile  Pro Arg Arg Pro Ser  Pro Tyr Glu 
    1175                 1180                 1185             


Lys Thr  Arg Asn Gln Arg Ile  Gln Glu Leu Ile Asp  Glu Met Arg 
    1190                 1195                 1200             


Lys Lys  Glu Met Leu Gly Lys  Phe 
    1205                 1210     


<210>  354
<211>  566
<212>  PRT
<213>  Homo Sapiens

<400>  354

Met Asp Pro Pro Ala Gly Ala Ala Arg Arg Leu Leu Cys Pro Ala Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Pro Pro Pro Leu Leu Pro Pro Pro Pro 
            20                  25                  30          


Pro Pro Ala Asn Ala Arg Leu Ala Ala Ala Ala Asp Pro Pro Gly Gly 
        35                  40                  45              


Pro Leu Gly His Gly Ala Glu Arg Ile Leu Ala Val Pro Val Arg Thr 
    50                  55                  60                  


Asp Ala Gln Gly Arg Leu Val Ser His Val Val Ser Ala Ala Thr Ser 
65                  70                  75                  80  


Arg Ala Gly Val Arg Ala Arg Arg Ala Ala Pro Val Arg Thr Pro Ser 
                85                  90                  95      


Phe Pro Gly Gly Asn Glu Glu Glu Pro Gly Ser His Leu Phe Tyr Asn 
            100                 105                 110         


Val Thr Val Phe Gly Arg Asp Leu His Leu Arg Leu Arg Pro Asn Ala 
        115                 120                 125             


Arg Leu Val Ala Pro Gly Ala Thr Met Glu Trp Gln Gly Glu Lys Gly 
    130                 135                 140                 


Thr Thr Arg Val Glu Pro Leu Leu Gly Ser Cys Leu Tyr Val Gly Asp 
145                 150                 155                 160 


Val Ala Gly Leu Ala Glu Ala Ser Ser Val Ala Leu Ser Asn Cys Asp 
                165                 170                 175     


Gly Leu Ala Gly Leu Ile Arg Met Glu Glu Glu Glu Phe Phe Ile Glu 
            180                 185                 190         


Pro Leu Glu Lys Gly Leu Ala Ala Gln Glu Ala Glu Gln Gly Arg Val 
        195                 200                 205             


His Val Val Tyr Arg Arg Pro Pro Thr Ser Pro Pro Leu Gly Gly Pro 
    210                 215                 220                 


Gln Ala Leu Asp Thr Gly Ala Ser Leu Asp Ser Leu Asp Ser Leu Ser 
225                 230                 235                 240 


Arg Ala Leu Gly Val Leu Glu Glu His Ala Asn Ser Ser Arg Arg Arg 
                245                 250                 255     


Ala Arg Arg His Ala Ala Asp Asp Asp Tyr Asn Ile Glu Val Leu Leu 
            260                 265                 270         


Gly Val Asp Asp Ser Val Val Gln Phe His Gly Lys Glu His Val Gln 
        275                 280                 285             


Lys Tyr Leu Leu Thr Leu Met Asn Ile Val Asn Glu Ile Tyr His Asp 
    290                 295                 300                 


Glu Ser Leu Gly Ala His Ile Asn Val Val Leu Val Arg Ile Ile Leu 
305                 310                 315                 320 


Leu Ser Tyr Gly Lys Ser Met Ser Leu Ile Glu Ile Gly Asn Pro Ser 
                325                 330                 335     


Gln Ser Leu Glu Asn Val Cys Arg Trp Ala Tyr Leu Gln Gln Lys Pro 
            340                 345                 350         


Asp Thr Gly His Asp Glu Tyr His Asp His Ala Ile Phe Leu Thr Arg 
        355                 360                 365             


Gln Asp Phe Gly Pro Ser Gly Met Gln Gly Tyr Ala Pro Val Thr Gly 
    370                 375                 380                 


Met Cys His Pro Val Arg Ser Cys Thr Leu Asn His Glu Asp Gly Phe 
385                 390                 395                 400 


Ser Ser Ala Phe Val Val Ala His Glu Thr Gly His Val Leu Gly Met 
                405                 410                 415     


Glu His Asp Gly Gln Gly Asn Arg Cys Gly Asp Glu Val Arg Leu Gly 
            420                 425                 430         


Ser Ile Met Ala Pro Leu Val Gln Ala Ala Phe His Arg Phe His Trp 
        435                 440                 445             


Ser Arg Cys Ser Gln Gln Glu Leu Ser Arg Tyr Leu His Ser Tyr Asp 
    450                 455                 460                 


Cys Leu Leu Asp Asp Pro Phe Ala His Asp Trp Pro Ala Leu Pro Gln 
465                 470                 475                 480 


Leu Pro Gly Leu His Tyr Ser Met Asn Glu Gln Cys Arg Phe Asp Phe 
                485                 490                 495     


Gly Leu Gly Tyr Met Met Cys Thr Ala Phe Arg Thr Phe Asp Pro Cys 
            500                 505                 510         


Lys Gln Leu Trp Cys Ser His Pro Asp Asn Pro Tyr Phe Cys Lys Thr 
        515                 520                 525             


Lys Lys Gly Pro Pro Leu Asp Gly Thr Met Cys Ala Pro Gly Lys Phe 
    530                 535                 540                 


Arg Pro Gly Ala Val Ala His Ala Cys Tyr Pro Ser Thr Leu Gly Gly 
545                 550                 555                 560 


Gln Gly Arg Trp Ile Ala 
                565     


<210>  355
<211>  106
<212>  PRT
<213>  Homo Sapiens

<400>  355

Val Thr Cys Gly Asn Gly Thr Gln Glu Arg Pro Val Leu Cys Arg Thr 
1               5                   10                  15      


Ala Asp Asp Ser Phe Gly Ile Cys Gln Glu Glu Arg Pro Glu Thr Ala 
            20                  25                  30          


Arg Thr Cys Arg Leu Gly Pro Cys Pro Arg Asn Ile Ser Asp Pro Ser 
        35                  40                  45              


Lys Lys Ser Tyr Val Val Gln Trp Leu Ser Arg Pro Asp Pro Asp Ser 
    50                  55                  60                  


Pro Ile Arg Lys Ile Ser Ser Ser Asn Arg Pro Val Tyr Asn Ser Ala 
65                  70                  75                  80  


Ser Ala Leu Gln Cys Met Pro Cys Ala Leu Trp Ser Leu Pro Trp Ala 
                85                  90                  95      


Pro Leu Leu Ser Val Tyr Gly Lys Leu Pro 
            100                 105     


<210>  356
<211>  1910
<212>  PRT
<213>  Homo Sapiens

<400>  356

Met Trp Val Ala Lys Trp Leu Thr Gly Leu Leu Tyr His Leu Ser Leu 
1               5                   10                  15      


Phe Ile Thr Arg Ser Trp Glu Val Asp Phe His Pro Arg Gln Glu Ala 
            20                  25                  30          


Leu Val Arg Thr Leu Thr Ser Tyr Glu Val Val Ile Pro Glu Arg Val 
        35                  40                  45              


Asn Glu Phe Gly Glu Val Phe Pro Gln Ser His His Phe Ser Arg Gln 
    50                  55                  60                  


Lys Arg Ser Ser Glu Ala Leu Glu Pro Met Pro Phe Arg Thr His Tyr 
65                  70                  75                  80  


Arg Phe Thr Ala Tyr Gly Gln Leu Phe Gln Leu Asn Leu Thr Ala Asp 
                85                  90                  95      


Ala Ser Phe Leu Ala Ala Gly Tyr Thr Glu Val His Leu Gly Thr Pro 
            100                 105                 110         


Glu Arg Gly Ala Trp Glu Ser Asp Ala Gly Pro Ser Asp Leu Arg His 
        115                 120                 125             


Cys Phe Tyr Arg Gly Gln Val Asn Ser Gln Glu Asp Tyr Lys Ala Val 
    130                 135                 140                 


Val Ser Leu Cys Gly Gly Leu Thr Gly Thr Phe Lys Gly Gln Asn Gly 
145                 150                 155                 160 


Glu Tyr Phe Leu Glu Pro Ile Met Lys Ala Asp Gly Asn Glu Tyr Glu 
                165                 170                 175     


Asp Gly His Asn Lys Pro His Leu Ile Tyr Arg Gln Asp Leu Asn Asn 
            180                 185                 190         


Ser Phe Leu Gln Thr Leu Lys Tyr Cys Ser Val Ser Glu Ser Gln Ile 
        195                 200                 205             


Lys Glu Thr Ser Leu Pro Phe His Thr Tyr Ser Asn Met Asn Glu Asp 
    210                 215                 220                 


Leu Asn Val Met Lys Glu Arg Val Leu Gly His Thr Ser Lys Asn Val 
225                 230                 235                 240 


Pro Leu Lys Asp Glu Arg Arg His Ser Arg Lys Lys Arg Leu Ile Ser 
                245                 250                 255     


Tyr Pro Arg Tyr Ile Glu Ile Met Val Thr Ala Asp Ala Lys Val Val 
            260                 265                 270         


Ser Ala His Gly Ser Asn Leu Gln Asn Tyr Ile Leu Thr Leu Met Ser 
        275                 280                 285             


Ile Val Ala Thr Ile Tyr Lys Asp Pro Ser Ile Gly Asn Leu Ile His 
    290                 295                 300                 


Ile Val Val Val Lys Leu Val Met Ile His Arg Glu Glu Glu Gly Pro 
305                 310                 315                 320 


Val Ile Asn Phe Asp Gly Ala Thr Thr Leu Lys Asn Phe Cys Ser Trp 
                325                 330                 335     


Gln Gln Thr Gln Asn Asp Leu Asp Asp Val His Pro Ser His His Asp 
            340                 345                 350         


Thr Ala Val Leu Ile Thr Arg Glu Asp Ile Cys Ser Ser Lys Glu Lys 
        355                 360                 365             


Cys Asn Met Leu Gly Leu Ser Tyr Leu Gly Thr Ile Cys Asp Pro Leu 
    370                 375                 380                 


Gln Ser Cys Phe Ile Asn Glu Glu Lys Gly Leu Ile Ser Ala Phe Thr 
385                 390                 395                 400 


Ile Ala His Glu Leu Gly His Thr Leu Gly Val Gln His Asp Asp Asn 
                405                 410                 415     


Pro Arg Cys Lys Glu Met Lys Val Thr Lys Tyr His Val Met Ala Pro 
            420                 425                 430         


Ala Leu Ser Phe His Met Ser Pro Trp Ser Trp Ser Asn Cys Ser Arg 
        435                 440                 445             


Lys Tyr Val Thr Glu Phe Leu Asp Thr Gly Tyr Gly Glu Cys Leu Leu 
    450                 455                 460                 


Asp Lys Pro Asp Glu Glu Ile Tyr Asn Leu Pro Ser Glu Leu Pro Gly 
465                 470                 475                 480 


Ser Arg Tyr Asp Gly Asn Lys Gln Cys Glu Leu Ala Phe Gly Pro Gly 
                485                 490                 495     


Ser Gln Met Cys Pro His Ile Asn Ile Cys Met His Leu Trp Cys Thr 
            500                 505                 510         


Ser Thr Glu Lys Leu His Lys Gly Cys Phe Thr Gln His Val Pro Pro 
        515                 520                 525             


Ala Asp Gly Thr Asp Cys Gly Pro Gly Met His Cys Arg His Gly Leu 
    530                 535                 540                 


Cys Val Asn Lys Glu Thr Glu Thr Arg Pro Val Asn Gly Glu Trp Gly 
545                 550                 555                 560 


Pro Trp Glu Pro Tyr Ser Ser Cys Ser Arg Thr Cys Gly Gly Gly Ile 
                565                 570                 575     


Glu Ser Ala Thr Arg Arg Cys Asn Arg Pro Glu Pro Arg Asn Gly Gly 
            580                 585                 590         


Asn Tyr Cys Val Gly Arg Arg Met Lys Phe Arg Ser Cys Asn Thr Asp 
        595                 600                 605             


Ser Cys Pro Lys Gly Thr Gln Asp Phe Arg Glu Lys Gln Cys Ser Asp 
    610                 615                 620                 


Phe Asn Gly Lys His Leu Asp Ile Ser Gly Ile Pro Ser Asn Val Arg 
625                 630                 635                 640 


Trp Leu Pro Arg Tyr Ser Gly Ile Gly Thr Lys Asp Arg Cys Lys Leu 
                645                 650                 655     


Tyr Cys Gln Val Ala Gly Thr Asn Tyr Phe Tyr Leu Leu Lys Asp Met 
            660                 665                 670         


Val Glu Asp Gly Thr Pro Cys Gly Thr Glu Thr His Asp Ile Cys Val 
        675                 680                 685             


Gln Gly Gln Cys Met Ala Ala Gly Cys Asp His Val Leu Asn Ser Ser 
    690                 695                 700                 


Ala Lys Ile Asp Lys Cys Gly Val Cys Gly Gly Asp Asn Ser Ser Cys 
705                 710                 715                 720 


Lys Thr Ile Thr Gly Val Phe Asn Ser Ser His Tyr Gly Tyr Asn Val 
                725                 730                 735     


Val Val Lys Ile Pro Ala Gly Ala Thr Asn Val Asp Ile Arg Gln Tyr 
            740                 745                 750         


Ser Tyr Ser Gly Gln Pro Asp Asp Ser Tyr Leu Ala Leu Ser Asp Ala 
        755                 760                 765             


Glu Gly Asn Phe Leu Phe Asn Gly Asn Phe Leu Leu Ser Thr Ser Lys 
    770                 775                 780                 


Lys Glu Ile Asn Val Gln Gly Thr Arg Thr Val Ile Glu Tyr Ser Gly 
785                 790                 795                 800 


Ser Asn Asn Ala Val Glu Arg Ile Asn Ser Thr Asn Arg Gln Glu Lys 
                805                 810                 815     


Glu Leu Ile Leu Gln Val Leu Cys Val Gly Asn Leu Tyr Asn Pro Asp 
            820                 825                 830         


Val His Tyr Ser Phe Asn Ile Pro Leu Glu Glu Arg Ser Asp Met Phe 
        835                 840                 845             


Thr Trp Asp Pro Tyr Gly Pro Trp Glu Gly Cys Thr Lys Met Cys Gln 
    850                 855                 860                 


Gly Leu Gln Arg Arg Asn Ile Thr Cys Ile His Lys Ser Asp His Ser 
865                 870                 875                 880 


Val Val Ser Asp Lys Glu Cys Asp His Leu Pro Leu Pro Ser Phe Val 
                885                 890                 895     


Thr Gln Ser Cys Asn Thr Asp Cys Glu Leu Arg Trp His Val Ile Gly 
            900                 905                 910         


Lys Ser Glu Cys Ser Ser Gln Cys Gly Gln Gly Tyr Arg Thr Leu Asp 
        915                 920                 925             


Ile His Cys Met Lys Tyr Ser Ile His Glu Gly Gln Thr Val Gln Val 
    930                 935                 940                 


Asp Asp His Tyr Cys Gly Asp Gln Leu Lys Pro Pro Thr Gln Glu Leu 
945                 950                 955                 960 


Cys His Gly Asn Cys Val Phe Thr Arg Trp His Tyr Ser Glu Trp Ser 
                965                 970                 975     


Gln Cys Ser Arg Ser Cys Gly Gly Gly Glu Arg Ser Arg Glu Ser Tyr 
            980                 985                 990         


Cys Met Asn Asn Phe Gly His Arg  Leu Ala Asp Asn Glu  Cys Gln Glu 
        995                 1000                 1005             


Leu Ser  Arg Val Thr Arg Glu  Asn Cys Asn Glu Phe  Ser Cys Pro 
    1010                 1015                 1020             


Ser Trp  Ala Ala Ser Glu Trp  Ser Glu Cys Leu Val  Thr Cys Gly 
    1025                 1030                 1035             


Lys Gly  Thr Lys Gln Arg Gln  Val Trp Cys Gln Leu  Asn Val Asp 
    1040                 1045                 1050             


His Leu  Ser Asp Gly Phe Cys  Asn Ser Ser Thr Lys  Pro Glu Ser 
    1055                 1060                 1065             


Leu Ser  Pro Cys Glu Leu His  Thr Cys Ala Ser Trp  Gln Val Gly 
    1070                 1075                 1080             


Pro Trp  Gly Pro Cys Thr Thr  Thr Cys Gly His Gly  Tyr Gln Met 
    1085                 1090                 1095             


Arg Asp  Val Lys Cys Val Asn  Glu Leu Ala Ser Ala  Val Leu Glu 
    1100                 1105                 1110             


Asp Thr  Glu Cys His Glu Ala  Ser Arg Pro Ser Asp  Arg Gln Ser 
    1115                 1120                 1125             


Cys Val  Leu Thr Pro Cys Ser  Phe Ile Ser Lys Leu  Glu Thr Ala 
    1130                 1135                 1140             


Leu Leu  Pro Thr Val Leu Ile  Lys Lys Met Ala Gln  Trp Arg His 
    1145                 1150                 1155             


Gly Ser  Trp Thr Pro Cys Ser  Val Ser Cys Gly Arg  Gly Thr Gln 
    1160                 1165                 1170             


Ala Arg  Tyr Val Ser Cys Arg  Asp Ala Leu Asp Arg  Ile Ala Asp 
    1175                 1180                 1185             


Glu Ser  Tyr Cys Ala His Leu  Pro Arg Pro Ala Glu  Ile Trp Asp 
    1190                 1195                 1200             


Cys Phe  Thr Pro Cys Gly Glu  Trp Gln Ala Gly Asp  Trp Ser Pro 
    1205                 1210                 1215             


Cys Ser  Ala Ser Cys Gly His  Gly Lys Thr Thr Arg  Gln Val Leu 
    1220                 1225                 1230             


Cys Met  Asn Tyr His Gln Pro  Ile Asp Glu Asn Tyr  Cys Asp Pro 
    1235                 1240                 1245             


Glu Val  Arg Pro Leu Met Glu  Gln Glu Cys Ser Leu  Ala Ala Cys 
    1250                 1255                 1260             


Pro Pro  Ala His Ser His Phe  Pro Ser Ser Pro Val  Gln Pro Ser 
    1265                 1270                 1275             


Tyr Tyr  Leu Ser Thr Asn Leu  Pro Leu Thr Gln Lys  Leu Glu Asp 
    1280                 1285                 1290             


Asn Glu  Asn Gln Val Val His  Pro Ser Val Arg Gly  Asn Gln Trp 
    1295                 1300                 1305             


Arg Thr  Gly Pro Trp Gly Ser  Cys Ser Ser Ser Cys  Ser Gly Gly 
    1310                 1315                 1320             


Leu Gln  His Arg Ala Val Val  Cys Gln Asp Glu Asn  Gly Gln Ser 
    1325                 1330                 1335             


Ala Ser  Tyr Cys Asp Ala Ala  Ser Lys Pro Pro Glu  Leu Gln Gln 
    1340                 1345                 1350             


Cys Gly  Pro Gly Pro Cys Pro  Gln Trp Asn Tyr Gly  Asn Trp Gly 
    1355                 1360                 1365             


Glu Cys  Ser Gln Thr Cys Gly  Gly Gly Ile Lys Ser  Arg Leu Val 
    1370                 1375                 1380             


Ile Cys  Gln Phe Pro Asn Gly  Gln Ile Leu Glu Asp  His Asn Cys 
    1385                 1390                 1395             


Glu Ile  Val Asn Lys Pro Pro  Ser Val Ile Gln Cys  His Met His 
    1400                 1405                 1410             


Ala Cys  Pro Ala Asp Val Ser  Trp His Gln Glu Pro  Trp Thr Ser 
    1415                 1420                 1425             


Cys Ser  Ala Ser Cys Gly Lys  Gly Arg Lys Tyr Arg  Glu Val Phe 
    1430                 1435                 1440             


Cys Ile  Asp Gln Phe Gln Arg  Lys Leu Glu Asp Thr  Asn Cys Ser 
    1445                 1450                 1455             


Gln Val  Gln Lys Pro Pro Thr  His Lys Ala Cys Arg  Ser Val Arg 
    1460                 1465                 1470             


Cys Pro  Ser Trp Lys Ala Asn  Ser Trp Asn Glu Cys  Ser Val Thr 
    1475                 1480                 1485             


Cys Gly  Ser Gly Val Gln Gln  Arg Asp Val Tyr Cys  Arg Leu Lys 
    1490                 1495                 1500             


Gly Val  Gly Gln Val Val Glu  Glu Met Cys Asp Gln  Ser Thr Arg 
    1505                 1510                 1515             


Pro Cys  Ser Gln Arg Arg Cys  Trp Ser Gln Asp Cys  Val Gln His 
    1520                 1525                 1530             


Lys Gly  Met Glu Arg Gly Arg  Leu Asn Cys Ser Thr  Ser Cys Glu 
    1535                 1540                 1545             


Arg Lys  Asp Ser His Gln Arg  Met Glu Cys Thr Asp  Asn Gln Ile 
    1550                 1555                 1560             


Arg Gln  Val Asn Glu Ile Val  Tyr Asn Ser Ser Thr  Ile Ser Leu 
    1565                 1570                 1575             


Thr Ser  Lys Asn Cys Arg Asn  Pro Pro Cys Asn Tyr  Ile Val Val 
    1580                 1585                 1590             


Thr Ala  Asp Ser Ser Gln Cys  Ala Asn Asn Cys Gly  Phe Ser Tyr 
    1595                 1600                 1605             


Arg Gln  Arg Ile Thr Tyr Cys  Thr Glu Ile Pro Ser  Thr Lys Lys 
    1610                 1615                 1620             


His Lys  Leu His Arg Leu Arg  Pro Ile Val Tyr Gln  Glu Cys Pro 
    1625                 1630                 1635             


Val Val  Pro Ser Ser Gln Val  Tyr Gln Cys Ile Asn  Ser Cys Leu 
    1640                 1645                 1650             


His Leu  Ala Thr Trp Lys Val  Gly Lys Trp Ser Lys  Cys Ser Val 
    1655                 1660                 1665             


Thr Cys  Gly Ile Gly Ile Met  Lys Arg Gln Val Lys  Cys Ile Thr 
    1670                 1675                 1680             


Lys His  Gly Leu Ser Ser Asp  Leu Cys Leu Asn His  Leu Lys Pro 
    1685                 1690                 1695             


Gly Ala  Gln Lys Lys Cys Tyr  Ala Asn Asp Cys Lys  Ser Phe Thr 
    1700                 1705                 1710             


Thr Cys  Lys Glu Ile Gln Val  Lys Asn His Ile Arg  Lys Asp Gly 
    1715                 1720                 1725             


Asp Tyr  Tyr Leu Asn Ile Lys  Gly Arg Ile Ile Lys  Ile Tyr Cys 
    1730                 1735                 1740             


Ala Asp  Met Tyr Leu Glu Asn  Pro Lys Glu Tyr Leu  Thr Leu Val 
    1745                 1750                 1755             


Gln Gly  Glu Glu Asn Phe Ser  Glu Val Tyr Gly Phe  Arg Leu Lys 
    1760                 1765                 1770             


Asn Pro  Tyr Gln Cys Pro Phe  Asn Gly Ser Arg Arg  Glu Asp Cys 
    1775                 1780                 1785             


Glu Cys  Asp Asn Gly His Leu  Ala Ala Gly Tyr Thr  Val Phe Ser 
    1790                 1795                 1800             


Lys Ile  Arg Ile Asp Leu Thr  Ser Met Gln Ile Lys  Thr Thr Asp 
    1805                 1810                 1815             


Leu Leu  Phe Ser Lys Thr Ile  Phe Gly Asn Ala Val  Pro Phe Ala 
    1820                 1825                 1830             


Thr Ala  Gly Asp Cys Tyr Ser  Ala Phe Arg Cys Pro  Gln Gly Gln 
    1835                 1840                 1845             


Phe Ser  Ile Asn Leu Ser Gly  Thr Gly Met Lys Ile  Ser Ser Thr 
    1850                 1855                 1860             


Ala Lys  Trp Leu Thr Gln Gly  Ser Tyr Thr Ser Val  Ser Ile Arg 
    1865                 1870                 1875             


Arg Ser  Glu Asp Gly Thr Arg  Phe Phe Gly Lys Cys  Gly Gly Tyr 
    1880                 1885                 1890             


Cys Gly  Lys Cys Leu Pro His  Met Thr Thr Gly Leu  Pro Ile Gln 
    1895                 1900                 1905             


Val Ile  
    1910 


<210>  357
<211>  1504
<212>  PRT
<213>  Homo Sapiens

<400>  357

Met Trp Val Ala Lys Trp Leu Thr Gly Leu Leu Tyr His Leu Ser Leu 
1               5                   10                  15      


Phe Ile Thr Arg Ser Trp Glu Val Asp Phe His Pro Arg Gln Glu Ala 
            20                  25                  30          


Leu Val Arg Thr Leu Thr Ser Tyr Glu Val Val Ile Pro Glu Arg Val 
        35                  40                  45              


Asn Glu Phe Gly Glu Val Phe Pro Gln Ser His His Phe Ser Arg Gln 
    50                  55                  60                  


Lys Arg Ser Ser Glu Ala Leu Glu Pro Met Pro Phe Arg Thr His Tyr 
65                  70                  75                  80  


Arg Phe Thr Ala Tyr Gly Gln Leu Phe Gln Leu Asn Leu Thr Ala Asp 
                85                  90                  95      


Ala Ser Phe Leu Ala Ala Gly Tyr Thr Glu Val His Leu Gly Thr Pro 
            100                 105                 110         


Glu Arg Gly Ala Trp Glu Ser Asp Ala Gly Pro Ser Asp Leu Arg His 
        115                 120                 125             


Cys Phe Tyr Arg Gly Gln Val Asn Ser Gln Glu Asp Tyr Lys Ala Val 
    130                 135                 140                 


Val Ser Leu Cys Gly Gly Leu Thr Gly Thr Phe Lys Gly Gln Asn Gly 
145                 150                 155                 160 


Glu Tyr Phe Leu Glu Pro Ile Met Lys Ala Asp Gly Asn Glu Tyr Glu 
                165                 170                 175     


Asp Gly His Asn Lys Pro His Leu Ile Tyr Arg Gln Asp Leu Asn Asn 
            180                 185                 190         


Ser Phe Leu Gln Thr Leu Lys Tyr Cys Ser Val Ser Glu Ser Gln Ile 
        195                 200                 205             


Lys Glu Thr Ser Leu Pro Phe His Thr Tyr Ser Asn Met Asn Glu Asp 
    210                 215                 220                 


Leu Asn Val Met Lys Glu Arg Val Leu Gly His Thr Ser Lys Asn Val 
225                 230                 235                 240 


Pro Leu Lys Asp Glu Arg Arg His Ser Arg Lys Lys Arg Leu Ile Ser 
                245                 250                 255     


Tyr Pro Arg Tyr Ile Glu Ile Met Val Thr Ala Asp Ala Lys Val Val 
            260                 265                 270         


Ser Ala His Gly Ser Asn Leu Gln Asn Tyr Ile Leu Thr Leu Met Ser 
        275                 280                 285             


Ile Val Ala Thr Ile Tyr Lys Asp Pro Ser Ile Gly Asn Leu Ile His 
    290                 295                 300                 


Ile Val Val Val Lys Leu Val Met Ile His Arg Glu Glu Glu Gly Pro 
305                 310                 315                 320 


Val Ile Asn Phe Asp Gly Ala Thr Thr Leu Lys Asn Phe Cys Ser Trp 
                325                 330                 335     


Gln Gln Thr Gln Asn Asp Leu Asp Asp Val His Pro Ser His His Asp 
            340                 345                 350         


Thr Ala Val Leu Ile Thr Arg Glu Asp Ile Cys Ser Ser Lys Glu Lys 
        355                 360                 365             


Cys Asn Met Leu Gly Leu Ser Tyr Leu Gly Thr Ile Cys Asp Pro Leu 
    370                 375                 380                 


Gln Ser Cys Phe Ile Asn Glu Glu Lys Gly Leu Ile Ser Ala Phe Thr 
385                 390                 395                 400 


Ile Ala His Glu Leu Gly His Thr Leu Gly Val Gln His Asp Asp Asn 
                405                 410                 415     


Pro Arg Cys Lys Glu Met Lys Val Thr Lys Tyr His Val Met Ala Pro 
            420                 425                 430         


Ala Leu Ser Phe His Met Ser Pro Trp Ser Trp Ser Asn Cys Ser Arg 
        435                 440                 445             


Lys Tyr Val Thr Glu Phe Leu Asp Thr Gly Tyr Gly Glu Cys Leu Leu 
    450                 455                 460                 


Asp Lys Pro Asp Glu Glu Ile Tyr Asn Leu Pro Ser Glu Leu Pro Gly 
465                 470                 475                 480 


Ser Arg Tyr Asp Gly Asn Lys Gln Cys Glu Leu Ala Phe Gly Pro Gly 
                485                 490                 495     


Ser Gln Met Cys Pro His Ile Asn Ile Cys Met His Leu Trp Cys Thr 
            500                 505                 510         


Ser Thr Glu Lys Leu His Lys Gly Cys Phe Thr Gln His Val Pro Pro 
        515                 520                 525             


Ala Asp Gly Thr Asp Cys Gly Pro Gly Met His Cys Arg His Gly Leu 
    530                 535                 540                 


Cys Val Asn Lys Glu Thr Glu Thr Arg Pro Val Asn Gly Glu Trp Gly 
545                 550                 555                 560 


Pro Trp Glu Pro Tyr Ser Ser Cys Ser Arg Thr Cys Gly Gly Gly Ile 
                565                 570                 575     


Glu Ser Ala Thr Arg Arg Cys Asn Arg Pro Glu Pro Arg Asn Gly Gly 
            580                 585                 590         


Asn Tyr Cys Val Gly Arg Arg Met Lys Phe Arg Ser Cys Asn Thr Asp 
        595                 600                 605             


Ser Cys Pro Lys Gly Thr Gln Asp Phe Arg Glu Lys Gln Cys Ser Asp 
    610                 615                 620                 


Phe Asn Gly Lys His Leu Asp Ile Ser Gly Ile Pro Ser Asn Val Arg 
625                 630                 635                 640 


Trp Leu Pro Arg Tyr Ser Gly Ile Gly Thr Lys Asp Arg Cys Lys Leu 
                645                 650                 655     


Tyr Cys Gln Val Ala Gly Thr Asn Tyr Phe Tyr Leu Leu Lys Asp Met 
            660                 665                 670         


Val Glu Asp Gly Thr Pro Cys Gly Thr Glu Thr His Asp Ile Cys Val 
        675                 680                 685             


Gln Gly Gln Cys Met Ala Ala Gly Cys Asp His Val Leu Asn Ser Ser 
    690                 695                 700                 


Ala Lys Ile Asp Lys Cys Gly Val Cys Gly Gly Asp Asn Ser Ser Cys 
705                 710                 715                 720 


Lys Thr Ile Thr Gly Val Phe Asn Ser Ser His Tyr Gly Tyr Asn Val 
                725                 730                 735     


Val Val Lys Ile Pro Ala Gly Ala Thr Asn Val Asp Ile Arg Gln Tyr 
            740                 745                 750         


Ser Tyr Ser Gly Gln Pro Asp Asp Ser Tyr Leu Ala Leu Ser Asp Ala 
        755                 760                 765             


Glu Gly Asn Phe Leu Phe Asn Gly Asn Phe Leu Leu Ser Thr Ser Lys 
    770                 775                 780                 


Lys Glu Ile Asn Val Gln Gly Thr Arg Thr Val Ile Glu Tyr Ser Gly 
785                 790                 795                 800 


Ser Asn Asn Ala Val Glu Arg Ile Asn Ser Thr Asn Arg Gln Glu Lys 
                805                 810                 815     


Glu Leu Ile Leu Gln Val Leu Cys Val Gly Asn Leu Tyr Asn Pro Asp 
            820                 825                 830         


Val His Tyr Ser Phe Asn Ile Pro Leu Glu Glu Arg Ser Asp Met Phe 
        835                 840                 845             


Thr Trp Asp Pro Tyr Gly Pro Trp Glu Gly Cys Thr Lys Met Cys Gln 
    850                 855                 860                 


Gly Leu Gln Arg Arg Asn Ile Thr Cys Ile His Lys Ser Asp His Ser 
865                 870                 875                 880 


Val Val Ser Asp Lys Glu Cys Asp His Leu Pro Leu Pro Ser Phe Val 
                885                 890                 895     


Thr Gln Ser Cys Asn Thr Asp Cys Glu Leu Arg Trp His Val Ile Gly 
            900                 905                 910         


Lys Ser Glu Cys Ser Ser Gln Cys Gly Gln Gly Tyr Arg Thr Leu Asp 
        915                 920                 925             


Ile His Cys Met Lys Tyr Ser Ile His Glu Gly Gln Thr Val Gln Val 
    930                 935                 940                 


Asp Asp His Tyr Cys Gly Asp Gln Leu Lys Pro Pro Thr Gln Glu Leu 
945                 950                 955                 960 


Cys His Gly Asn Cys Val Phe Thr Arg Trp His Tyr Ser Glu Trp Ser 
                965                 970                 975     


Gln Cys Ser Arg Ser Cys Gly Gly Gly Glu Arg Ser Arg Glu Ser Tyr 
            980                 985                 990         


Cys Met Asn Asn Phe Gly His Arg  Leu Ala Asp Asn Glu  Cys Gln Glu 
        995                 1000                 1005             


Leu Ser  Arg Val Thr Arg Glu  Asn Cys Asn Glu Phe  Ser Cys Pro 
    1010                 1015                 1020             


Ser Trp  Ala Ala Ser Glu Trp  Ser Glu Cys Leu Val  Thr Cys Gly 
    1025                 1030                 1035             


Lys Gly  Thr Lys Gln Arg Gln  Val Trp Cys Gln Leu  Asn Val Asp 
    1040                 1045                 1050             


His Leu  Ser Asp Gly Phe Cys  Asn Ser Ser Thr Lys  Pro Glu Ser 
    1055                 1060                 1065             


Leu Ser  Pro Cys Glu Leu His  Thr Cys Ala Ser Trp  Gln Val Gly 
    1070                 1075                 1080             


Pro Trp  Gly Pro Cys Thr Thr  Thr Cys Gly His Gly  Tyr Gln Met 
    1085                 1090                 1095             


Arg Asp  Val Lys Cys Val Asn  Glu Leu Ala Ser Ala  Val Leu Glu 
    1100                 1105                 1110             


Asp Thr  Glu Cys His Glu Ala  Ser Arg Pro Ser Asp  Arg Gln Ser 
    1115                 1120                 1125             


Cys Val  Leu Thr Pro Cys Ser  Phe Ile Ser Lys Leu  Glu Thr Ala 
    1130                 1135                 1140             


Leu Leu  Pro Thr Val Leu Ile  Lys Lys Met Ala Gln  Trp Arg His 
    1145                 1150                 1155             


Gly Ser  Trp Thr Pro Cys Ser  Val Ser Cys Gly Arg  Gly Thr Gln 
    1160                 1165                 1170             


Ala Arg  Tyr Val Ser Cys Arg  Asp Ala Leu Asp Arg  Ile Ala Asp 
    1175                 1180                 1185             


Glu Ser  Tyr Cys Ala His Leu  Pro Arg Pro Ala Glu  Ile Trp Asp 
    1190                 1195                 1200             


Cys Phe  Thr Pro Cys Gly Glu  Trp Gln Ala Gly Asp  Trp Ser Pro 
    1205                 1210                 1215             


Cys Ser  Ala Ser Cys Gly His  Gly Lys Thr Thr Arg  Gln Val Leu 
    1220                 1225                 1230             


Cys Met  Asn Tyr His Gln Pro  Ile Asp Glu Asn Tyr  Cys Asp Pro 
    1235                 1240                 1245             


Glu Val  Arg Pro Leu Met Glu  Gln Glu Cys Ser Leu  Ala Ala Cys 
    1250                 1255                 1260             


Pro Pro  Ala His Ser His Phe  Pro Ser Ser Pro Val  Gln Pro Ser 
    1265                 1270                 1275             


Tyr Tyr  Leu Ser Thr Asn Leu  Pro Leu Thr Gln Lys  Leu Glu Asp 
    1280                 1285                 1290             


Asn Glu  Asn Gln Val Val His  Pro Ser Val Arg Gly  Asn Gln Trp 
    1295                 1300                 1305             


Arg Thr  Gly Pro Trp Gly Ser  Cys Ser Ser Ser Cys  Ser Gly Gly 
    1310                 1315                 1320             


Leu Gln  His Arg Ala Val Val  Cys Gln Asp Glu Asn  Gly Gln Ser 
    1325                 1330                 1335             


Ala Ser  Tyr Cys Asp Ala Ala  Ser Lys Pro Pro Glu  Leu Gln Gln 
    1340                 1345                 1350             


Cys Gly  Pro Gly Pro Cys Pro  Gln Trp Asn Tyr Gly  Asn Trp Gly 
    1355                 1360                 1365             


Glu Cys  Ser Gln Thr Cys Gly  Gly Gly Ile Lys Ser  Arg Leu Val 
    1370                 1375                 1380             


Ile Cys  Gln Phe Pro Asn Gly  Gln Ile Leu Glu Asp  His Asn Cys 
    1385                 1390                 1395             


Glu Ile  Val Asn Lys Pro Pro  Ser Val Ile Gln Cys  His Met His 
    1400                 1405                 1410             


Ala Cys  Pro Ala Asp Val Ser  Trp His Gln Glu Pro  Trp Thr Ser 
    1415                 1420                 1425             


Glu Asp  Leu Lys Val Lys Leu  Leu Pro Gln Arg Thr  Ile Ile Leu 
    1430                 1435                 1440             


Trp Glu  Leu Met Lys Asn Ile  Phe Cys His Gly Lys  His Ser His 
    1445                 1450                 1455             


Met Tyr  Leu Ile Asn Val Val  Thr Asp His Leu Leu  Tyr Pro Arg 
    1460                 1465                 1470             


His Cys  Asp Pro Glu Thr Ile  Glu Thr Tyr Phe Leu  Ser Leu Trp 
    1475                 1480                 1485             


Ser Leu  Gln Phe Thr Trp Gly  Asp Leu Lys Tyr Tyr  Lys Asn Ser 
    1490                 1495                 1500             


Leu 
    


<210>  358
<211>  1504
<212>  PRT
<213>  Homo Sapiens

<400>  358

Met Trp Val Ala Lys Trp Leu Thr Gly Leu Leu Tyr His Leu Ser Leu 
1               5                   10                  15      


Phe Ile Thr Arg Ser Trp Glu Val Asp Phe His Pro Arg Gln Glu Ala 
            20                  25                  30          


Leu Val Arg Thr Leu Thr Ser Tyr Glu Val Val Ile Pro Glu Arg Val 
        35                  40                  45              


Asn Glu Phe Gly Glu Val Phe Pro Gln Ser His His Phe Ser Arg Gln 
    50                  55                  60                  


Lys Arg Ser Ser Glu Ala Leu Glu Pro Met Pro Phe Arg Thr His Tyr 
65                  70                  75                  80  


Arg Phe Thr Ala Tyr Gly Gln Leu Phe Gln Leu Asn Leu Thr Ala Asp 
                85                  90                  95      


Ala Ser Phe Leu Ala Ala Gly Tyr Thr Glu Val His Leu Gly Thr Pro 
            100                 105                 110         


Glu Arg Gly Ala Trp Glu Ser Asp Ala Gly Pro Ser Asp Leu Arg His 
        115                 120                 125             


Cys Phe Tyr Arg Gly Gln Val Asn Ser Gln Glu Asp Tyr Lys Ala Val 
    130                 135                 140                 


Val Ser Leu Cys Gly Gly Leu Val Gly Thr Phe Lys Gly Gln Asn Gly 
145                 150                 155                 160 


Glu Tyr Phe Leu Glu Pro Ile Met Lys Ala Asp Gly Asn Glu Tyr Glu 
                165                 170                 175     


Asp Gly His Asn Lys Pro His Leu Ile Tyr Arg Gln Asp Leu Asn Asn 
            180                 185                 190         


Ser Phe Leu Gln Thr Leu Lys Tyr Cys Ser Val Ser Glu Ser Gln Ile 
        195                 200                 205             


Lys Glu Thr Ser Leu Pro Phe His Thr Tyr Ser Asn Met Asn Glu Asp 
    210                 215                 220                 


Leu Asn Val Met Lys Glu Arg Val Leu Gly His Thr Ser Lys Asn Val 
225                 230                 235                 240 


Pro Leu Lys Asp Glu Arg Arg His Ser Arg Lys Lys Arg Leu Ile Ser 
                245                 250                 255     


Tyr Pro Arg Tyr Ile Glu Ile Met Val Thr Ala Asp Ala Lys Val Val 
            260                 265                 270         


Ser Ala His Gly Ser Asn Leu Gln Asn Tyr Ile Leu Thr Leu Met Ser 
        275                 280                 285             


Ile Val Ala Thr Ile Tyr Lys Asp Pro Ser Ile Gly Asn Leu Ile His 
    290                 295                 300                 


Ile Val Val Val Lys Leu Val Met Ile His Arg Glu Glu Glu Gly Pro 
305                 310                 315                 320 


Val Ile Asn Phe Asp Gly Ala Thr Thr Leu Lys Asn Phe Cys Ser Trp 
                325                 330                 335     


Gln Gln Thr Gln Asn Asp Leu Asp Asp Val His Pro Ser His His Asp 
            340                 345                 350         


Thr Ala Val Leu Ile Thr Arg Tyr Asp Ile Cys Ser Ser Lys Glu Lys 
        355                 360                 365             


Cys Asn Met Leu Gly Leu Ser Tyr Leu Gly Thr Ile Cys Asp Pro Leu 
    370                 375                 380                 


Gln Ser Cys Phe Ile Asn Glu Glu Lys Gly Leu Ile Ser Ala Phe Thr 
385                 390                 395                 400 


Ile Ala His Glu Leu Gly His Thr Leu Gly Val Gln His Asp Asp Asn 
                405                 410                 415     


Pro Arg Cys Lys Glu Met Lys Val Thr Lys Tyr His Val Met Ala Pro 
            420                 425                 430         


Ala Leu Ser Phe His Met Ser Pro Trp Ser Trp Ser Asn Cys Ser Arg 
        435                 440                 445             


Lys Tyr Val Thr Glu Phe Leu Asp Thr Gly Tyr Gly Glu Cys Leu Leu 
    450                 455                 460                 


Asp Lys Pro Asp Glu Glu Ile Tyr Asn Leu Pro Ser Glu Leu Pro Gly 
465                 470                 475                 480 


Ser Arg Tyr Asp Gly Asn Lys Gln Cys Glu Leu Ala Phe Gly Pro Gly 
                485                 490                 495     


Ser Gln Met Cys Pro His Ile Asn Ile Cys Met His Leu Trp Cys Thr 
            500                 505                 510         


Ser Thr Glu Lys Leu His Lys Gly Cys Phe Thr Gln His Val Pro Pro 
        515                 520                 525             


Ala Asp Gly Thr Asp Cys Gly Pro Gly Met His Cys Arg His Gly Leu 
    530                 535                 540                 


Cys Val Asn Lys Glu Thr Glu Thr Arg Pro Val Asn Gly Glu Trp Gly 
545                 550                 555                 560 


Pro Trp Glu Pro Tyr Ser Ser Cys Ser Arg Thr Cys Gly Gly Gly Ile 
                565                 570                 575     


Glu Ser Ala Thr Arg Arg Cys Asn Arg Pro Glu Pro Arg Asn Gly Gly 
            580                 585                 590         


Asn Tyr Cys Val Gly Arg Arg Met Lys Phe Arg Ser Cys Asn Thr Asp 
        595                 600                 605             


Ser Cys Pro Lys Gly Thr Gln Asp Phe Arg Glu Lys Gln Cys Ser Asp 
    610                 615                 620                 


Phe Asn Gly Lys His Leu Asp Ile Ser Gly Ile Pro Ser Asn Val Arg 
625                 630                 635                 640 


Trp Leu Pro Arg Tyr Ser Gly Ile Gly Thr Lys Asp Arg Cys Lys Leu 
                645                 650                 655     


Tyr Cys Gln Val Ala Gly Thr Asn Tyr Phe Tyr Leu Leu Lys Asp Met 
            660                 665                 670         


Val Glu Asp Gly Thr Pro Cys Gly Thr His Ser Tyr Asn Ile Asp Cys 
        675                 680                 685             


Asn Cys Val Leu Lys Ala Ala Gly Cys Asp His Val Leu Asn Ser Ser 
    690                 695                 700                 


Ala Lys Ile Asp Lys Cys Gly Val Cys Gly Gly Asp Asn Ser Ser Cys 
705                 710                 715                 720 


Lys Thr Ile Thr Gly Val Phe Asn Ser Ser His Tyr Gly Tyr Asn Val 
                725                 730                 735     


Val Val Lys Ile Pro Ala Gly Ala Thr Asn Val Asp Ile Arg Gln Tyr 
            740                 745                 750         


Ser Tyr Ser Gly Gln Pro Asp Asp Ser Tyr Leu Ala Leu Ser Asp Ala 
        755                 760                 765             


Glu Gly Asn Phe Leu Phe Asn Gly Asn Phe Leu Leu Ser Thr Ser Lys 
    770                 775                 780                 


Lys Glu Ile Asn Val Gln Gly Thr Arg Thr Val Ile Glu Tyr Ser Gly 
785                 790                 795                 800 


Ser Asn Asn Ala Val Glu Arg Ile Asn Ser Thr Asn Arg Gln Glu Lys 
                805                 810                 815     


Glu Ile Leu Ile Glu Val Leu Cys Val Gly Asn Leu Tyr Asn Pro Asp 
            820                 825                 830         


Val His Tyr Ser Phe Asn Ile Pro Leu Glu Glu Arg Ser Asp Met Phe 
        835                 840                 845             


Thr Trp Asp Pro Tyr Gly Pro Trp Glu Gly Cys Thr Lys Met Cys Gln 
    850                 855                 860                 


Gly Leu Gln Arg Arg Asn Ile Thr Cys Ile His Lys Ser Asp His Ser 
865                 870                 875                 880 


Val Val Ser Asp Lys Glu Cys Asp His Leu Pro Leu Pro Ser Phe Val 
                885                 890                 895     


Thr Gln Ser Cys Asn Thr Asp Cys Glu Leu Arg Trp His Val Ile Gly 
            900                 905                 910         


Lys Ser Glu Cys Ser Ser Gln Cys Gly Gln Gly Tyr Arg Thr Leu Asp 
        915                 920                 925             


Ile His Cys Met Lys Tyr Ser Ile His Glu Gly Gln Thr Val Gln Val 
    930                 935                 940                 


Asp Asp His Tyr Cys Gly Asp Gln Leu Lys Pro Pro Thr Gln Glu Leu 
945                 950                 955                 960 


Cys His Gly Asn Cys Val Phe Thr Arg Trp His Tyr Ser Glu Trp Ser 
                965                 970                 975     


Gln Cys Ser Arg Ser Cys Gly Gly Gly Glu Arg Ser Arg Glu Ser Tyr 
            980                 985                 990         


Cys Met Asn Asn Phe Gly His Arg  Leu Ala Asp Asn Glu  Cys Gln Glu 
        995                 1000                 1005             


Leu Ser  Arg Val Thr Arg Glu  Asn Cys Asn Glu Phe  Ser Cys Pro 
    1010                 1015                 1020             


Ser Trp  Ala Ala Ser Glu Trp  Ser Glu Cys Leu Val  Thr Cys Gly 
    1025                 1030                 1035             


Lys Gly  Thr Lys Gln Arg Gln  Val Trp Cys Gln Leu  Asn Val Asp 
    1040                 1045                 1050             


His Leu  Ser Asp Gly Phe Cys  Asn Ser Ser Thr Lys  Pro Glu Ser 
    1055                 1060                 1065             


Leu Ser  Pro Cys Glu Leu His  Thr Cys Ala Ser Trp  Gln Val Gly 
    1070                 1075                 1080             


Pro Trp  Gly Pro Cys Thr Thr  Thr Cys Gly His Gly  Tyr Gln Met 
    1085                 1090                 1095             


Arg Asp  Val Lys Cys Val Asn  Glu Leu Ala Ser Ala  Val Leu Glu 
    1100                 1105                 1110             


Asp Thr  Glu Cys His Glu Ala  Ser Arg Pro Ser Asp  Arg Gln Ser 
    1115                 1120                 1125             


Cys Val  Leu Thr Pro Cys Ser  Phe Ile Ser Lys Leu  Glu Thr Ala 
    1130                 1135                 1140             


Leu Leu  Pro Thr Val Leu Ile  Lys Lys Met Ala Gln  Trp Arg His 
    1145                 1150                 1155             


Gly Ser  Trp Thr Pro Cys Ser  Val Ser Cys Gly Arg  Gly Thr Gln 
    1160                 1165                 1170             


Ala Arg  Tyr Val Ser Cys Arg  Asp Ala Leu Asp Arg  Ile Ala Asp 
    1175                 1180                 1185             


Glu Ser  Tyr Cys Ala His Leu  Pro Arg Pro Ala Glu  Ile Trp Asp 
    1190                 1195                 1200             


Cys Phe  Thr Pro Cys Gly Glu  Trp Gln Ala Gly Asp  Trp Ser Pro 
    1205                 1210                 1215             


Cys Ser  Ala Ser Cys Gly His  Gly Lys Thr Thr Arg  Gln Val Leu 
    1220                 1225                 1230             


Cys Met  Asn Tyr His Gln Pro  Ile Asp Glu Asn Tyr  Cys Asp Pro 
    1235                 1240                 1245             


Glu Val  Arg Pro Leu Met Glu  Gln Glu Cys Ser Leu  Ala Ala Cys 
    1250                 1255                 1260             


Pro Pro  Ala His Ser His Phe  Pro Ser Ser Pro Val  Gln Pro Ser 
    1265                 1270                 1275             


Tyr Tyr  Leu Ser Thr Asn Leu  Pro Leu Thr Gln Lys  Leu Glu Asp 
    1280                 1285                 1290             


Asn Glu  Asn Gln Val Val His  Pro Ser Val Arg Gly  Asn Gln Trp 
    1295                 1300                 1305             


Arg Thr  Gly Pro Trp Gly Gln  Cys Ser Ser Ser Cys  Ser Gly Gly 
    1310                 1315                 1320             


Leu Gln  His Arg Ala Val Val  Cys Gln Asp Glu Asn  Gly Gln Ser 
    1325                 1330                 1335             


Ala Ser  Tyr Cys Asp Ala Ala  Ser Lys Pro Pro Glu  Leu Gln Gln 
    1340                 1345                 1350             


Cys Gly  Pro Gly Pro Cys Pro  Gln Trp Asn Tyr Gly  Asn Trp Gly 
    1355                 1360                 1365             


Glu Cys  Ser Gln Thr Cys Gly  Gly Gly Ile Lys Ser  Arg Leu Val 
    1370                 1375                 1380             


Ile Cys  Gln Phe Pro Asn Gly  Gln Ile Leu Glu Asp  His Asn Cys 
    1385                 1390                 1395             


Glu Ile  Val Asn Lys Pro Pro  Ser Val Ile Gln Cys  His Met His 
    1400                 1405                 1410             


Ala Cys  Pro Ala Asp Val Ser  Trp His Gln Glu Pro  Trp Thr Ser 
    1415                 1420                 1425             


Glu Asp  Leu Lys Val Lys Leu  Leu Pro Gln Arg Thr  Ile Ile Leu 
    1430                 1435                 1440             


Trp Glu  Leu Met Lys Asn Ile  Phe Cys His Gly Lys  His Ser His 
    1445                 1450                 1455             


Met Tyr  Leu Ile Asn Val Val  Thr Asp His Leu Leu  Tyr Pro Arg 
    1460                 1465                 1470             


His Cys  Asp Pro Glu Thr Ile  Glu Thr Tyr Phe Leu  Ser Leu Trp 
    1475                 1480                 1485             


Ser Leu  Gln Phe Thr Trp Gly  Asp Leu Lys Tyr Tyr  Lys Asn Ser 
    1490                 1495                 1500             


Leu 
    


<210>  359
<211>  634
<212>  PRT
<213>  Homo Sapiens

<400>  359

Tyr Ser Phe Asn Ile Pro Leu Glu Glu Arg Ser Asp Met Phe Thr Trp 
1               5                   10                  15      


Asp Pro Tyr Gly Pro Trp Glu Gly Cys Thr Lys Met Cys Gln Gly Leu 
            20                  25                  30          


Gln Arg Arg Asn Ile Thr Cys Ile His Lys Ser Asp His Ser Val Val 
        35                  40                  45              


Ser Asp Lys Glu Cys Asp His Leu Pro Leu Pro Ser Phe Val Thr Gln 
    50                  55                  60                  


Ser Cys Asn Thr Asp Cys Glu Leu Arg Trp His Val Ile Gly Lys Ser 
65                  70                  75                  80  


Glu Cys Ser Ser Gln Cys Gly Gln Gly Tyr Arg Thr Leu Asp Ile His 
                85                  90                  95      


Cys Met Lys Tyr Ser Ile His Glu Gly Gln Thr Val Gln Val Asp Asp 
            100                 105                 110         


His Tyr Cys Gly Asp Gln Leu Lys Pro Pro Thr Gln Glu Leu Cys His 
        115                 120                 125             


Gly Asn Cys Val Phe Thr Arg Trp His Tyr Ser Glu Trp Ser Gln Cys 
    130                 135                 140                 


Ser Arg Ser Cys Gly Gly Gly Glu Arg Ser Arg Glu Ser Tyr Cys Met 
145                 150                 155                 160 


Asn Asn Phe Gly His Arg Leu Ala Asp Asn Glu Cys Gln Glu Leu Ser 
                165                 170                 175     


Arg Val Thr Arg Glu Asn Cys Asn Glu Phe Ser Cys Pro Ser Trp Ala 
            180                 185                 190         


Ala Ser Glu Trp Ser Glu Cys Leu Val Thr Cys Gly Lys Gly Thr Lys 
        195                 200                 205             


Gln Arg Gln Val Trp Cys Gln Leu Asn Val Asp His Leu Ser Asp Gly 
    210                 215                 220                 


Phe Cys Asn Ser Ser Thr Lys Pro Glu Ser Leu Ser Pro Cys Glu Leu 
225                 230                 235                 240 


His Thr Cys Ala Ser Trp Gln Val Gly Pro Trp Gly Pro Cys Thr Thr 
                245                 250                 255     


Thr Cys Gly His Gly Tyr Gln Met Arg Asp Val Lys Cys Val Asn Glu 
            260                 265                 270         


Leu Ala Ser Ala Val Leu Glu Asp Thr Glu Cys His Glu Ala Ser Arg 
        275                 280                 285             


Pro Ser Asp Arg Gln Cys Ser Val Ser Cys Gly Arg Gly Thr Gln Ala 
    290                 295                 300                 


Arg Tyr Val Ser Cys Arg Asp Ala Leu Asp Arg Ile Ala Asp Glu Ser 
305                 310                 315                 320 


Tyr Cys Ala His Leu Pro Arg Pro Ala Glu Ile Trp Asp Cys Phe Thr 
                325                 330                 335     


Pro Cys Gly Glu Trp Gln Ala Gly Asp Trp Ser Pro Cys Ser Ala Ser 
            340                 345                 350         


Cys Gly His Gly Lys Thr Thr Arg Gln Val Leu Cys Met Asn Tyr His 
        355                 360                 365             


Gln Pro Ile Asp Glu Asn Tyr Cys Asp Pro Glu Val Arg Pro Leu Met 
    370                 375                 380                 


Glu Gln Glu Cys Ser Leu Ala Ala Cys Pro Pro Ala His Ser His Phe 
385                 390                 395                 400 


Pro Ser Ser Pro Val Gln Pro Ser Tyr Tyr Leu Ser Thr Asn Leu Pro 
                405                 410                 415     


Leu Thr Gln Lys Leu Glu Asp Asn Glu Asn Gln Val Val His Pro Ser 
            420                 425                 430         


Val Arg Gly Asn Gln Trp Arg Thr Gly Pro Trp Gly Ser Cys Ser Ser 
        435                 440                 445             


Ser Cys Ser Gly Gly Leu Gln His Arg Ala Val Val Cys Gln Asp Glu 
    450                 455                 460                 


Asn Gly Gln Ser Ala Ser Tyr Cys Asp Ala Ala Ser Lys Pro Pro Glu 
465                 470                 475                 480 


Leu Gln Gln Cys Gly Pro Gly Pro Cys Pro Gln Trp Asn Tyr Gly Asn 
                485                 490                 495     


Trp Gly Glu Cys Ser Gln Thr Cys Gly Gly Gly Ile Lys Ser Arg Leu 
            500                 505                 510         


Val Ile Cys Gln Phe Pro Asn Gly Gln Ile Leu Glu Asp His Asn Cys 
        515                 520                 525             


Glu Ile Val Asn Lys Pro Pro Ser Val Ile Gln Cys His Met His Ala 
    530                 535                 540                 


Cys Pro Ala Asp Val Ser Trp His Gln Glu Pro Trp Thr Ser Glu Asp 
545                 550                 555                 560 


Leu Lys Val Lys Leu Leu Pro Gln Arg Thr Ile Ile Leu Trp Glu Leu 
                565                 570                 575     


Met Lys Asn Ile Phe Cys His Gly Lys His Ser His Met Tyr Leu Ile 
            580                 585                 590         


Asn Val Val Thr Asp His Leu Leu Tyr Pro Arg His Cys Asp Pro Glu 
        595                 600                 605             


Thr Ile Glu Thr Tyr Phe Leu Ser Leu Trp Ser Leu Gln Phe Thr Trp 
    610                 615                 620                 


Gly Asp Leu Lys Tyr Tyr Lys Asn Ser Leu 
625                 630                 


<210>  360
<211>  1205
<212>  PRT
<213>  Homo Sapiens

<400>  360

Met Val Leu Leu Ser Leu Trp Leu Ile Ala Ala Ala Leu Val Glu Val 
1               5                   10                  15      


Arg Thr Ser Ala Asp Gly Gln Ala Gly Asn Glu Glu Met Val Gln Ile 
            20                  25                  30          


Asp Leu Pro Ile Lys Arg Tyr Arg Glu Tyr Glu Leu Val Thr Pro Val 
        35                  40                  45              


Ser Thr Asn Leu Glu Gly Arg Tyr Leu Ser His Thr Leu Ser Ala Ser 
    50                  55                  60                  


His Lys Lys Arg Ser Ala Arg Asp Val Ser Ser Asn Pro Glu Gln Leu 
65                  70                  75                  80  


Phe Phe Asn Ile Thr Ala Phe Gly Lys Asp Phe His Leu Arg Leu Lys 
                85                  90                  95      


Pro Asn Thr Gln Leu Val Ala Pro Gly Ala Val Val Glu Trp His Glu 
            100                 105                 110         


Thr Ser Leu Val Pro Gly Asn Ile Thr Asp Pro Ile Asn Asn His Gln 
        115                 120                 125             


Pro Gly Ser Ala Thr Tyr Arg Ile Arg Arg Thr Glu Pro Leu Gln Thr 
    130                 135                 140                 


Asn Cys Ala Tyr Val Gly Asp Ile Val Asp Ile Pro Gly Thr Ser Val 
145                 150                 155                 160 


Ala Ile Ser Asn Cys Asp Gly Leu Ala Gly Met Ile Lys Ser Asp Asn 
                165                 170                 175     


Glu Glu Tyr Phe Ile Glu Pro Leu Glu Arg Gly Lys Gln Met Glu Glu 
            180                 185                 190         


Glu Lys Gly Arg Ile His Val Val Tyr Lys Arg Ser Ala Val Glu Gln 
        195                 200                 205             


Ala Pro Ile Asp Met Ser Lys Asp Phe His Tyr Arg Glu Ser Asp Leu 
    210                 215                 220                 


Glu Gly Leu Asp Asp Leu Gly Thr Val Tyr Gly Asn Ile His Gln Gln 
225                 230                 235                 240 


Leu Asn Glu Thr Met Arg Arg Arg Arg His Ala Gly Glu Asn Asp Tyr 
                245                 250                 255     


Asn Ile Glu Val Leu Leu Gly Val Asp Asp Ser Val Val Arg Phe His 
            260                 265                 270         


Gly Lys Glu His Val Gln Asn Tyr Leu Leu Thr Leu Met Asn Ile Val 
        275                 280                 285             


Asn Glu Ile Tyr His Asp Glu Ser Leu Gly Val His Ile Asn Val Val 
    290                 295                 300                 


Leu Val Arg Met Ile Met Leu Gly Tyr Ala Lys Ser Ile Ser Leu Ile 
305                 310                 315                 320 


Glu Arg Gly Asn Pro Ser Arg Ser Leu Glu Asn Val Cys Arg Trp Ala 
                325                 330                 335     


Ser Gln Gln Gln Arg Ser Asp Leu Asn His Ser Glu His His Asp His 
            340                 345                 350         


Ala Ile Phe Leu Thr Arg Gln Asp Phe Gly Pro Ala Gly Met Gln Gly 
        355                 360                 365             


Tyr Ala Pro Val Thr Gly Met Cys His Pro Val Arg Ser Cys Thr Leu 
    370                 375                 380                 


Asn His Glu Asp Gly Phe Ser Ser Ala Phe Val Val Ala His Glu Thr 
385                 390                 395                 400 


Gly His Val Leu Gly Met Glu His Asp Gly Gln Gly Asn Arg Cys Gly 
                405                 410                 415     


Asp Glu Thr Ala Met Gly Ser Val Met Ala Pro Leu Val Gln Ala Ala 
            420                 425                 430         


Phe His Arg Tyr His Trp Ser Arg Cys Ser Gly Gln Glu Leu Lys Arg 
        435                 440                 445             


Tyr Ile His Ser Tyr Asp Cys Leu Leu Asp Asp Pro Phe Asp His Asp 
    450                 455                 460                 


Trp Pro Lys Leu Pro Glu Leu Pro Gly Ile Asn Tyr Ser Met Asp Glu 
465                 470                 475                 480 


Gln Cys Arg Phe Asp Phe Gly Val Gly Tyr Lys Met Cys Thr Ala Phe 
                485                 490                 495     


Arg Thr Phe Asp Pro Cys Lys Gln Leu Trp Cys Ser His Pro Asp Asn 
            500                 505                 510         


Pro Tyr Phe Cys Lys Thr Lys Lys Gly Pro Pro Leu Asp Gly Thr Glu 
        515                 520                 525             


Cys Ala Ala Gly Lys Trp Cys Tyr Lys Gly His Cys Met Trp Lys Asn 
    530                 535                 540                 


Ala Asn Gln Gln Lys Gln Asp Gly Asn Trp Gly Ser Trp Thr Lys Phe 
545                 550                 555                 560 


Gly Ser Cys Ser Arg Thr Cys Gly Thr Gly Val Arg Phe Arg Thr Arg 
                565                 570                 575     


Gln Cys Asn Asn Pro Met Pro Ile Asn Gly Gly Gln Asp Cys Pro Gly 
            580                 585                 590         


Val Asn Phe Glu Tyr Gln Leu Cys Asn Thr Glu Glu Cys Gln Lys His 
        595                 600                 605             


Phe Glu Asp Phe Arg Ala Gln Gln Cys Gln Gln Arg Asn Ser His Phe 
    610                 615                 620                 


Glu Tyr Gln Asn Thr Lys His His Trp Leu Pro Tyr Glu His Pro Asp 
625                 630                 635                 640 


Pro Lys Lys Arg Cys His Leu Tyr Cys Gln Ser Lys Glu Thr Gly Asp 
                645                 650                 655     


Val Ala Tyr Met Lys Gln Leu Val His Asp Gly Thr His Cys Ser Tyr 
            660                 665                 670         


Lys Asp Pro Tyr Ser Ile Cys Val Arg Gly Glu Cys Val Lys Val Gly 
        675                 680                 685             


Cys Asp Lys Glu Ile Gly Ser Asn Lys Val Glu Asp Lys Cys Gly Val 
    690                 695                 700                 


Cys Gly Gly Asp Asn Ser His Cys Arg Thr Val Lys Gly Thr Phe Thr 
705                 710                 715                 720 


Arg Thr Pro Arg Lys Leu Gly Tyr Leu Lys Met Phe Asp Ile Pro Pro 
                725                 730                 735     


Gly Ala Arg His Val Leu Ile Gln Glu Asp Glu Ala Ser Pro His Ile 
            740                 745                 750         


Leu Ala Ile Lys Asn Gln Ala Thr Gly His Tyr Ile Leu Asn Gly Lys 
        755                 760                 765             


Gly Glu Glu Ala Lys Ser Arg Thr Phe Ile Asp Leu Gly Val Glu Trp 
    770                 775                 780                 


Asp Tyr Asn Ile Glu Asp Asp Ile Glu Ser Leu His Thr Asp Gly Pro 
785                 790                 795                 800 


Leu His Asp Pro Val Ile Val Leu Ile Ile Pro Gln Glu Asn Asp Thr 
                805                 810                 815     


Arg Ser Ser Leu Thr Tyr Lys Tyr Ile Ile His Glu Asp Ser Val Pro 
            820                 825                 830         


Thr Ile Asn Ser Asn Asn Val Ile Gln Glu Glu Leu Asp Thr Phe Glu 
        835                 840                 845             


Trp Ala Leu Lys Ser Trp Ser Gln Cys Ser Lys Pro Cys Gly Gly Gly 
    850                 855                 860                 


Phe Gln Tyr Thr Lys Tyr Gly Cys Arg Arg Lys Ser Asp Asn Lys Met 
865                 870                 875                 880 


Val His Arg Ser Phe Cys Glu Ala Asn Lys Lys Pro Lys Pro Ile Arg 
                885                 890                 895     


Arg Met Cys Asn Ile Gln Glu Cys Thr His Pro Leu Trp Val Ala Glu 
            900                 905                 910         


Glu Trp Glu His Cys Thr Lys Thr Cys Gly Ser Ser Gly Tyr Gln Leu 
        915                 920                 925             


Arg Thr Val Arg Cys Leu Gln Pro Leu Leu Asp Gly Thr Asn Arg Ser 
    930                 935                 940                 


Val His Ser Lys Tyr Cys Met Gly Asp Arg Pro Glu Ser Arg Arg Pro 
945                 950                 955                 960 


Cys Asn Arg Val Pro Cys Pro Ala Gln Trp Lys Thr Gly Pro Trp Ser 
                965                 970                 975     


Glu Cys Ser Val Thr Cys Gly Glu Gly Thr Glu Val Arg Gln Val Leu 
            980                 985                 990         


Cys Arg Ala Gly Asp His Cys Asp  Gly Glu Lys Pro Glu  Ser Val Arg 
        995                 1000                 1005             


Ala Cys  Gln Leu Pro Pro Cys  Asn Asp Glu Pro Cys  Leu Gly Asp 
    1010                 1015                 1020             


Lys Ser  Ile Phe Cys Gln Met  Glu Val Leu Ala Arg  Tyr Cys Ser 
    1025                 1030                 1035             


Ile Pro  Gly Tyr Asn Lys Leu  Cys Cys Glu Ser Cys  Ser Lys Arg 
    1040                 1045                 1050             


Ser Ser  Thr Leu Pro Pro Pro  Tyr Leu Leu Glu Ala  Ala Glu Thr 
    1055                 1060                 1065             


His Asp  Asp Val Ile Ser Asn  Pro Ser Asp Leu Pro  Arg Ser Leu 
    1070                 1075                 1080             


Val Met  Pro Thr Ser Leu Val  Pro Tyr His Ser Glu  Thr Pro Ala 
    1085                 1090                 1095             


Lys Lys  Met Ser Leu Ser Ser  Ile Ser Ser Val Gly  Gly Pro Asn 
    1100                 1105                 1110             


Ala Tyr  Ala Ala Phe Arg Pro  Asn Ser Lys Pro Asp  Gly Ala Asn 
    1115                 1120                 1125             


Leu Arg  Gln Arg Ser Ala Gln  Gln Ala Gly Ser Lys  Thr Val Arg 
    1130                 1135                 1140             


Leu Val  Thr Val Pro Ser Ser  Pro Pro Thr Lys Arg  Val His Leu 
    1145                 1150                 1155             


Ser Ser  Ala Ser Gln Met Ala  Ala Ala Ser Phe Phe  Ala Ala Ser 
    1160                 1165                 1170             


Asp Ser  Ile Gly Ala Ser Ser  Gln Ala Arg Thr Ser  Lys Lys Asp 
    1175                 1180                 1185             


Gly Lys  Ile Ile Asp Asn Arg  Arg Pro Thr Arg Ser  Ser Thr Leu 
    1190                 1195                 1200             


Glu Arg  
    1205 


<210>  361
<211>  1205
<212>  PRT
<213>  Homo Sapiens

<400>  361

Met Val Leu Leu Ser Leu Trp Leu Ile Ala Ala Ala Leu Val Glu Val 
1               5                   10                  15      


Arg Thr Ser Ala Asp Gly Gln Ala Gly Asn Glu Glu Met Val Gln Ile 
            20                  25                  30          


Asp Leu Pro Ile Lys Arg Tyr Arg Glu Tyr Glu Leu Val Thr Pro Val 
        35                  40                  45              


Ser Thr Asn Leu Glu Gly Arg Tyr Leu Ser His Thr Leu Ser Ala Ser 
    50                  55                  60                  


His Lys Lys Arg Ser Ala Arg Asp Val Ser Ser Asn Pro Glu Gln Leu 
65                  70                  75                  80  


Phe Phe Asn Ile Thr Ala Phe Gly Lys Asp Phe His Leu Arg Leu Lys 
                85                  90                  95      


Pro Asn Thr Gln Leu Val Ala Pro Gly Ala Val Val Glu Trp His Glu 
            100                 105                 110         


Thr Ser Leu Val Pro Gly Asn Ile Thr Asp Pro Ile Asn Asn His Gln 
        115                 120                 125             


Pro Gly Ser Ala Thr Tyr Arg Ile Arg Arg Thr Glu Pro Leu Gln Thr 
    130                 135                 140                 


Asn Cys Ala Tyr Val Gly Asp Ile Val Asp Ile Pro Gly Thr Ser Val 
145                 150                 155                 160 


Ala Ile Ser Asn Cys Asp Gly Leu Ala Gly Met Ile Lys Ser Asp Asn 
                165                 170                 175     


Glu Glu Tyr Phe Ile Glu Pro Leu Glu Arg Gly Lys Gln Met Glu Glu 
            180                 185                 190         


Glu Lys Gly Arg Ile His Val Val Tyr Lys Arg Ser Ala Val Glu Gln 
        195                 200                 205             


Ala Pro Ile Asp Met Ser Lys Asp Phe His Tyr Arg Glu Ser Asp Leu 
    210                 215                 220                 


Glu Gly Leu Asp Asp Leu Gly Thr Val Tyr Gly Asn Ile His Gln Gln 
225                 230                 235                 240 


Leu Asn Glu Thr Met Arg Arg Arg Arg His Ala Gly Glu Asn Asp Tyr 
                245                 250                 255     


Asn Ile Glu Val Leu Leu Gly Val Asp Asp Ser Val Val Arg Phe His 
            260                 265                 270         


Gly Lys Glu His Val Gln Asn Tyr Leu Leu Thr Leu Met Asn Ile Val 
        275                 280                 285             


Asn Glu Ile Tyr His Asp Glu Ser Leu Gly Val His Ile Asn Val Val 
    290                 295                 300                 


Leu Val Arg Met Ile Met Leu Gly Tyr Ala Lys Ser Ile Ser Leu Ile 
305                 310                 315                 320 


Glu Arg Gly Asn Pro Ser Arg Ser Leu Glu Asn Val Cys Arg Trp Ala 
                325                 330                 335     


Ser Gln Gln Gln Arg Ser Asp Leu Asn His Ser Glu His His Asp His 
            340                 345                 350         


Ala Ile Phe Leu Thr Arg Gln Asp Phe Gly Pro Ala Gly Met Gln Gly 
        355                 360                 365             


Tyr Ala Pro Val Thr Gly Met Cys His Pro Val Arg Ser Cys Thr Leu 
    370                 375                 380                 


Asn His Glu Asp Gly Phe Ser Ser Ala Phe Val Val Ala His Glu Thr 
385                 390                 395                 400 


Gly His Val Leu Gly Met Glu His Asp Gly Gln Gly Asn Arg Cys Gly 
                405                 410                 415     


Asp Glu Thr Ala Met Gly Ser Val Met Ala Pro Leu Val Gln Ala Ala 
            420                 425                 430         


Phe His Arg Tyr His Trp Ser Arg Cys Ser Gly Gln Glu Leu Lys Arg 
        435                 440                 445             


Tyr Ile His Ser Tyr Asp Cys Leu Leu Asp Asp Pro Phe Asp His Asp 
    450                 455                 460                 


Trp Pro Lys Leu Pro Glu Leu Pro Gly Ile Asn Tyr Ser Met Asp Glu 
465                 470                 475                 480 


Gln Cys Arg Phe Asp Phe Gly Val Gly Tyr Lys Met Cys Thr Ala Phe 
                485                 490                 495     


Arg Thr Phe Asp Pro Cys Lys Gln Leu Trp Cys Ser His Pro Asp Asn 
            500                 505                 510         


Pro Tyr Phe Cys Lys Thr Lys Lys Gly Pro Pro Leu Asp Gly Thr Glu 
        515                 520                 525             


Cys Ala Ala Gly Lys Trp Cys Tyr Lys Gly His Cys Met Trp Lys Asn 
    530                 535                 540                 


Ala Asn Gln Gln Lys Gln Asp Gly Asn Trp Gly Ser Trp Thr Lys Phe 
545                 550                 555                 560 


Gly Ser Cys Ser Arg Thr Cys Gly Thr Gly Val Arg Phe Arg Thr Arg 
                565                 570                 575     


Gln Cys Asn Asn Pro Met Pro Ile Asn Gly Gly Gln Asp Cys Pro Gly 
            580                 585                 590         


Val Asn Phe Glu Tyr Gln Leu Cys Asn Thr Glu Glu Cys Gln Lys His 
        595                 600                 605             


Phe Glu Asp Phe Arg Ala Gln Gln Cys Gln Gln Arg Asn Ser His Phe 
    610                 615                 620                 


Glu Tyr Gln Asn Thr Lys His His Trp Leu Pro Tyr Glu His Pro Asp 
625                 630                 635                 640 


Pro Lys Lys Arg Cys His Leu Tyr Cys Gln Ser Lys Glu Thr Gly Asp 
                645                 650                 655     


Val Ala Tyr Met Lys Gln Leu Val His Asp Gly Thr His Cys Ser Tyr 
            660                 665                 670         


Lys Asp Pro Tyr Ser Ile Cys Val Arg Gly Glu Cys Val Lys Val Gly 
        675                 680                 685             


Cys Asp Lys Glu Ile Gly Ser Asn Lys Val Glu Asp Lys Cys Gly Val 
    690                 695                 700                 


Cys Gly Gly Asp Asn Ser His Cys Arg Thr Val Lys Gly Thr Phe Thr 
705                 710                 715                 720 


Arg Thr Pro Arg Lys Leu Gly Tyr Leu Lys Met Phe Asp Ile Pro Pro 
                725                 730                 735     


Gly Ala Arg His Val Leu Ile Gln Glu Asp Glu Ala Ser Pro His Ile 
            740                 745                 750         


Leu Ala Ile Lys Asn Gln Ala Thr Gly His Tyr Ile Leu Asn Gly Lys 
        755                 760                 765             


Gly Glu Glu Ala Lys Ser Arg Thr Phe Ile Asp Leu Gly Val Glu Trp 
    770                 775                 780                 


Asp Tyr Asn Ile Glu Asp Asp Ile Glu Ser Leu His Thr Asp Gly Pro 
785                 790                 795                 800 


Leu His Asp Pro Val Ile Val Leu Ile Ile Pro Gln Glu Asn Asp Thr 
                805                 810                 815     


Arg Ser Ser Leu Thr Tyr Lys Tyr Ile Ile His Glu Asp Ser Val Pro 
            820                 825                 830         


Thr Ile Asn Ser Asn Asn Val Ile Gln Glu Glu Leu Asp Thr Phe Glu 
        835                 840                 845             


Trp Ala Leu Lys Ser Trp Ser Gln Cys Ser Lys Pro Cys Gly Gly Gly 
    850                 855                 860                 


Phe Gln Tyr Thr Lys Tyr Gly Cys Arg Arg Lys Ser Asp Asn Lys Met 
865                 870                 875                 880 


Val His Arg Ser Phe Cys Glu Ala Asn Lys Lys Pro Lys Pro Ile Arg 
                885                 890                 895     


Arg Met Cys Asn Ile Gln Glu Cys Thr His Pro Leu Trp Val Ala Glu 
            900                 905                 910         


Glu Trp Glu His Cys Thr Lys Thr Cys Gly Ser Ser Gly Tyr Gln Leu 
        915                 920                 925             


Arg Thr Val Arg Cys Leu Gln Pro Leu Leu Asp Gly Thr Asn Arg Ser 
    930                 935                 940                 


Val His Ser Lys Tyr Cys Met Gly Asp Arg Pro Glu Ser Arg Arg Pro 
945                 950                 955                 960 


Cys Asn Arg Val Pro Cys Pro Ala Gln Trp Lys Thr Gly Pro Trp Ser 
                965                 970                 975     


Glu Cys Ser Val Thr Cys Gly Glu Gly Thr Glu Val Arg Gln Val Leu 
            980                 985                 990         


Cys Arg Ala Gly Asp His Cys Asp  Gly Glu Lys Pro Glu  Ser Val Arg 
        995                 1000                 1005             


Ala Cys  Gln Leu Pro Pro Cys  Asn Asp Glu Pro Cys  Leu Gly Asp 
    1010                 1015                 1020             


Lys Ser  Ile Phe Cys Gln Met  Glu Val Leu Ala Arg  Tyr Cys Ser 
    1025                 1030                 1035             


Ile Pro  Gly Tyr Asn Lys Leu  Cys Cys Glu Ser Cys  Ser Lys Arg 
    1040                 1045                 1050             


Ser Ser  Thr Leu Pro Pro Pro  Tyr Leu Leu Glu Ala  Ala Glu Thr 
    1055                 1060                 1065             


His Asp  Asp Val Ile Ser Asn  Pro Ser Asp Leu Pro  Arg Ser Leu 
    1070                 1075                 1080             


Val Met  Pro Thr Ser Leu Val  Pro Tyr His Ser Glu  Thr Pro Ala 
    1085                 1090                 1095             


Lys Lys  Met Ser Leu Ser Ser  Ile Ser Ser Val Gly  Gly Pro Asn 
    1100                 1105                 1110             


Ala Tyr  Ala Ala Phe Arg Pro  Asn Ser Lys Pro Asp  Gly Ala Asn 
    1115                 1120                 1125             


Leu Arg  Gln Arg Ser Ala Gln  Gln Ala Gly Ser Lys  Thr Val Arg 
    1130                 1135                 1140             


Leu Val  Thr Val Pro Ser Ser  Pro Pro Thr Lys Arg  Val His Leu 
    1145                 1150                 1155             


Ser Ser  Ala Ser Gln Met Ala  Ala Ala Ser Phe Phe  Ala Ala Ser 
    1160                 1165                 1170             


Asp Ser  Ile Gly Ala Ser Ser  Gln Ala Arg Thr Ser  Lys Lys Asp 
    1175                 1180                 1185             


Gly Lys  Ile Ile Asp Asn Arg  Arg Pro Thr Arg Ser  Ser Thr Leu 
    1190                 1195                 1200             


Glu Arg  
    1205 


<210>  362
<211>  930
<212>  PRT
<213>  Homo Sapiens

<400>  362

Met Leu Leu Gly Trp Ala Ser Leu Leu Leu Cys Ala Phe Arg Leu Pro 
1               5                   10                  15      


Leu Ala Ala Val Gly Pro Ala Ala Thr Pro Ala Gln Asp Lys Ala Gly 
            20                  25                  30          


Gln Pro Pro Thr Ala Ala Ala Ala Ala Gln Pro Arg Arg Arg Gln Gly 
        35                  40                  45              


Glu Glu Val Gln Glu Arg Ala Glu Pro Pro Gly His Pro His Pro Leu 
    50                  55                  60                  


Ala Gln Arg Arg Arg Ser Lys Gly Leu Val Gln Asn Ile Asp Gln Leu 
65                  70                  75                  80  


Tyr Ser Gly Gly Gly Lys Val Gly Tyr Leu Val Tyr Ala Gly Gly Arg 
                85                  90                  95      


Arg Phe Leu Leu Asp Leu Glu Arg Asp Gly Ser Val Gly Ile Ala Gly 
            100                 105                 110         


Phe Val Pro Ala Gly Gly Gly Thr Ser Ala Pro Trp Arg His Arg Ser 
        115                 120                 125             


His Cys Phe Tyr Arg Gly Thr Val Asp Gly Ser Pro Arg Ser Leu Ala 
    130                 135                 140                 


Val Phe Asp Leu Cys Gly Gly Leu Asp Gly Phe Phe Ala Val Lys His 
145                 150                 155                 160 


Ala Arg Tyr Thr Leu Lys Pro Leu Leu Arg Gly Pro Trp Ala Glu Glu 
                165                 170                 175     


Glu Lys Gly Arg Val Tyr Gly Asp Gly Ser Ala Arg Ile Leu His Val 
            180                 185                 190         


Tyr Thr Arg Glu Gly Phe Ser Phe Glu Ala Leu Pro Pro Arg Ala Ser 
        195                 200                 205             


Cys Glu Thr Pro Ala Ser Thr Pro Glu Ala His Glu His Ala Pro Ala 
    210                 215                 220                 


His Ser Asn Pro Ser Gly Arg Ala Ala Leu Ala Ser Gln Leu Leu Asp 
225                 230                 235                 240 


Gln Ser Ala Leu Ser Pro Ala Gly Gly Ser Gly Pro Gln Thr Trp Trp 
                245                 250                 255     


Arg Arg Arg Arg Arg Ser Ile Ser Arg Ala Arg Gln Val Glu Leu Leu 
            260                 265                 270         


Leu Val Ala Asp Ala Ser Met Ala Arg Leu Tyr Gly Arg Gly Leu Gln 
        275                 280                 285             


His Tyr Leu Leu Thr Leu Ala Ser Ile Ala Asn Arg Leu Tyr Ser His 
    290                 295                 300                 


Ala Ser Ile Glu Asn His Ile Arg Leu Ala Val Val Lys Val Val Val 
305                 310                 315                 320 


Leu Gly Asp Lys Asp Lys Ser Leu Glu Val Ser Lys Asn Ala Ala Thr 
                325                 330                 335     


Thr Leu Lys Asn Phe Cys Lys Trp Gln His Gln His Asn Gln Leu Gly 
            340                 345                 350         


Asp Asp His Glu Glu His Tyr Asp Ala Ala Ile Leu Phe Thr Arg Glu 
        355                 360                 365             


Asp Leu Cys Gly His His Ser Cys Asp Thr Leu Gly Met Ala Asp Val 
    370                 375                 380                 


Gly Thr Ile Cys Ser Pro Glu Arg Ser Cys Ala Val Ile Glu Asp Asp 
385                 390                 395                 400 


Gly Leu His Ala Ala Phe Thr Val Ala His Glu Ile Gly His Leu Leu 
                405                 410                 415     


Gly Leu Ser His Asp Asp Ser Lys Phe Cys Glu Glu Thr Phe Gly Ser 
            420                 425                 430         


Thr Glu Asp Lys Arg Leu Met Ser Ser Ile Leu Thr Ser Ile Asp Ala 
        435                 440                 445             


Ser Lys Pro Trp Ser Lys Cys Thr Ser Ala Thr Ile Thr Glu Phe Leu 
    450                 455                 460                 


Asp Asp Gly His Gly Asn Cys Leu Leu Asp Leu Pro Arg Lys Gln Ile 
465                 470                 475                 480 


Leu Gly Pro Glu Glu Leu Pro Gly Gln Thr Tyr Asp Ala Thr Gln Gln 
                485                 490                 495     


Cys Asn Leu Thr Phe Gly Pro Glu Tyr Ser Val Cys Pro Gly Met Asp 
            500                 505                 510         


Val Cys Ala Arg Leu Trp Cys Ala Val Val Arg Gln Gly Gln Met Val 
        515                 520                 525             


Cys Leu Thr Lys Lys Leu Pro Ala Val Glu Gly Thr Pro Cys Gly Lys 
    530                 535                 540                 


Gly Arg Ile Cys Leu Gln Gly Lys Cys Val Asp Lys Thr Lys Lys Lys 
545                 550                 555                 560 


Tyr Tyr Ser Thr Ser Ser His Gly Asn Trp Gly Ser Trp Gly Ser Trp 
                565                 570                 575     


Gly Gln Cys Ser Arg Ser Cys Gly Gly Gly Val Gln Phe Ala Tyr Arg 
            580                 585                 590         


His Cys Asn Asn Pro Ala Pro Arg Asn Asn Gly Arg Tyr Cys Thr Gly 
        595                 600                 605             


Lys Arg Ala Ile Tyr Arg Ser Cys Ser Leu Met Pro Cys Pro Pro Asn 
    610                 615                 620                 


Gly Lys Ser Phe Arg His Glu Gln Cys Glu Ala Lys Asn Gly Tyr Gln 
625                 630                 635                 640 


Ser Asp Ala Lys Gly Val Lys Thr Phe Val Glu Trp Val Pro Lys Tyr 
                645                 650                 655     


Ala Gly Val Leu Pro Ala Asp Val Cys Lys Leu Thr Cys Arg Ala Lys 
            660                 665                 670         


Gly Thr Gly Tyr Tyr Val Val Phe Ser Pro Lys Val Thr Asp Gly Thr 
        675                 680                 685             


Glu Cys Arg Leu Tyr Ser Asn Ser Val Cys Val Arg Gly Lys Cys Val 
    690                 695                 700                 


Arg Thr Gly Cys Asp Gly Ile Ile Gly Ser Lys Leu Gln Tyr Asp Lys 
705                 710                 715                 720 


Cys Gly Val Cys Gly Gly Asp Asn Ser Ser Cys Thr Lys Ile Val Gly 
                725                 730                 735     


Thr Phe Asn Lys Lys Ser Lys Gly Tyr Thr Asp Val Val Arg Ile Pro 
            740                 745                 750         


Glu Gly Ala Thr His Ile Lys Val Arg Gln Phe Lys Ala Lys Asp Gln 
        755                 760                 765             


Thr Arg Phe Thr Ala Tyr Leu Ala Leu Lys Lys Lys Asn Gly Glu Tyr 
    770                 775                 780                 


Leu Ile Asn Gly Lys Tyr Met Ile Ser Thr Ser Glu Thr Ile Ile Asp 
785                 790                 795                 800 


Ile Asn Gly Thr Val Met Asn Tyr Ser Gly Trp Ser His Arg Asp Asp 
                805                 810                 815     


Phe Leu His Gly Met Gly Tyr Ser Ala Thr Lys Glu Ile Leu Ile Val 
            820                 825                 830         


Gln Ile Leu Ala Thr Asp Pro Thr Lys Pro Leu Asp Val Arg Tyr Ser 
        835                 840                 845             


Phe Phe Val Pro Lys Lys Ser Thr Pro Lys Val Asn Ser Val Thr Ser 
    850                 855                 860                 


His Gly Ser Asn Lys Val Gly Ser His Thr Ser Gln Pro Gln Trp Val 
865                 870                 875                 880 


Thr Gly Pro Trp Leu Ala Cys Ser Arg Thr Cys Asp Thr Gly Trp His 
                885                 890                 895     


Thr Arg Thr Val Gln Cys Gln Asp Gly Asn Arg Lys Leu Ala Lys Gly 
            900                 905                 910         


Cys Pro Leu Ser Gln Arg Pro Ser Ala Phe Lys Gln Cys Leu Leu Lys 
        915                 920                 925             


Lys Cys 
    930 


<210>  363
<211>  292
<212>  PRT
<213>  Homo Sapiens

<400>  363

Met Glu Ile Leu Trp Lys Thr Leu Thr Trp Ile Leu Ser Leu Ile Met 
1               5                   10                  15      


Ala Ser Ser Glu Phe His Ser Asp His Arg Leu Ser Tyr Ser Ser Gln 
            20                  25                  30          


Glu Glu Phe Leu Thr Tyr Leu Glu His Tyr Gln Leu Thr Ile Pro Ile 
        35                  40                  45              


Arg Val Asp Gln Asn Gly Ala Phe Leu Ser Phe Thr Val Lys Asn Asp 
    50                  55                  60                  


Lys His Ser Arg Arg Arg Arg Ser Met Asp Pro Ile Asp Pro Gln Gln 
65                  70                  75                  80  


Ala Val Ser Lys Leu Phe Phe Lys Leu Ser Ala Tyr Gly Lys His Phe 
                85                  90                  95      


His Leu Asn Leu Thr Leu Asn Thr Asp Phe Val Ser Lys His Phe Thr 
            100                 105                 110         


Val Glu Tyr Trp Gly Lys Asp Gly Pro Gln Trp Lys His Asp Phe Leu 
        115                 120                 125             


Asp Asn Cys His Tyr Thr Gly Tyr Leu Gln Asp Gln Arg Ser Thr Thr 
    130                 135                 140                 


Lys Val Ala Leu Ser Asn Cys Val Gly Leu His Gly Val Ile Ala Thr 
145                 150                 155                 160 


Glu Asp Glu Glu Tyr Phe Ile Glu Pro Leu Lys Asn Thr Thr Glu Asp 
                165                 170                 175     


Ser Lys His Phe Ser Tyr Glu Asn Gly His Pro His Val Ile Tyr Lys 
            180                 185                 190         


Lys Ser Ala Leu Gln Gln Arg His Leu Tyr Asp His Ser His Cys Gly 
        195                 200                 205             


Val Ser Asp Phe Thr Arg Ser Gly Lys Pro Trp Trp Leu Asn Asp Thr 
    210                 215                 220                 


Ser Thr Val Ser Tyr Ser Leu Pro Ile Asn Asn Thr His Ile His His 
225                 230                 235                 240 


Arg Gln Lys Arg Ser Val Ser Ile Glu Arg Phe Val Glu Thr Leu Val 
                245                 250                 255     


Val Ala Asp Lys Met Met Val Gly Tyr His Gly Arg Lys Asp Ile Glu 
            260                 265                 270         


His Tyr Ile Leu Ser Val Met Asn Ile Val Arg Leu Pro Asn Phe Thr 
        275                 280                 285             


Val Ile Pro Ala 
    290         


<210>  364
<211>  1117
<212>  PRT
<213>  Homo Sapiens

<400>  364

Met Glu Ile Leu Trp Lys Thr Leu Thr Trp Ile Leu Ser Leu Ile Met 
1               5                   10                  15      


Ala Ser Ser Glu Phe His Ser Asp His Arg Leu Ser Tyr Ser Ser Gln 
            20                  25                  30          


Glu Glu Phe Leu Thr Tyr Leu Glu His Tyr Gln Leu Thr Ile Pro Ile 
        35                  40                  45              


Arg Val Asp Gln Asn Gly Ala Phe Leu Ser Phe Thr Val Lys Asn Asp 
    50                  55                  60                  


Lys His Ser Arg Arg Arg Arg Ser Met Asp Pro Ile Asp Pro Gln Gln 
65                  70                  75                  80  


Ala Val Ser Lys Leu Phe Phe Lys Leu Ser Ala Tyr Gly Lys His Phe 
                85                  90                  95      


His Leu Asn Leu Thr Leu Asn Thr Asp Phe Val Ser Lys His Phe Thr 
            100                 105                 110         


Val Glu Tyr Trp Gly Lys Asp Gly Pro Gln Trp Lys His Asp Phe Leu 
        115                 120                 125             


Asp Asn Cys His Tyr Thr Gly Tyr Leu Gln Asp Gln Arg Ser Thr Thr 
    130                 135                 140                 


Lys Val Ala Leu Ser Asn Cys Val Gly Leu His Gly Val Ile Ala Thr 
145                 150                 155                 160 


Glu Asp Glu Glu Tyr Phe Ile Glu Pro Leu Lys Asn Thr Thr Glu Asp 
                165                 170                 175     


Ser Lys His Phe Ser Tyr Glu Asn Gly His Pro His Val Ile Tyr Lys 
            180                 185                 190         


Lys Ser Ala Leu Gln Gln Arg His Leu Tyr Asp His Ser His Cys Gly 
        195                 200                 205             


Val Ser Asp Phe Thr Arg Ser Gly Lys Pro Trp Trp Leu Asn Asp Thr 
    210                 215                 220                 


Ser Thr Val Ser Tyr Ser Leu Pro Ile Asn Asn Thr His Ile His His 
225                 230                 235                 240 


Arg Gln Lys Arg Ser Val Ser Ile Glu Arg Phe Val Glu Thr Leu Val 
                245                 250                 255     


Val Ala Asp Lys Met Met Val Gly Tyr His Gly Arg Lys Asp Ile Glu 
            260                 265                 270         


His Tyr Ile Leu Ser Val Met Asn Ile Val Ala Lys Leu Tyr Arg Asp 
        275                 280                 285             


Ser Ser Leu Gly Asn Val Val Asn Ile Ile Val Ala Arg Leu Ile Val 
    290                 295                 300                 


Leu Thr Glu Asp Gln Pro Asn Leu Glu Ile Asn His His Ala Asp Lys 
305                 310                 315                 320 


Ser Leu Asp Ser Phe Cys Lys Trp Gln Lys Ser Ile Leu Ser His Gln 
                325                 330                 335     


Ser Asp Gly Asn Thr Ile Pro Glu Asn Gly Ile Ala His His Asp Asn 
            340                 345                 350         


Ala Val Leu Ile Thr Arg Tyr Asp Ile Cys Thr Tyr Lys Asn Lys Pro 
        355                 360                 365             


Cys Gly Thr Leu Gly Leu Ala Ser Val Ala Gly Met Cys Glu Pro Glu 
    370                 375                 380                 


Arg Ser Cys Ser Ile Asn Glu Asp Ile Gly Leu Gly Ser Ala Phe Thr 
385                 390                 395                 400 


Ile Ala His Glu Ile Gly His Asn Phe Gly Met Asn His Asp Gly Ile 
                405                 410                 415     


Gly Asn Ser Cys Gly Thr Lys Gly His Glu Ala Ala Lys Leu Met Ala 
            420                 425                 430         


Ala His Ile Thr Ala Asn Thr Asn Pro Phe Ser Trp Ser Ala Cys Ser 
        435                 440                 445             


Arg Asp Tyr Ile Thr Ser Phe Leu Asp Ser Gly Arg Gly Thr Cys Leu 
    450                 455                 460                 


Asp Asn Glu Pro Pro Lys Arg Asp Phe Leu Tyr Pro Ala Val Ala Pro 
465                 470                 475                 480 


Gly Gln Val Tyr Asp Ala Asp Glu Gln Cys Arg Phe Gln Tyr Gly Ala 
                485                 490                 495     


Thr Ser Arg Gln Cys Lys Tyr Gly Glu Val Cys Arg Glu Leu Trp Cys 
            500                 505                 510         


Leu Ser Lys Ser Asn Arg Cys Val Thr Asn Ser Ile Pro Ala Ala Glu 
        515                 520                 525             


Gly Thr Leu Cys Gln Thr Gly Asn Ile Glu Lys Gly Trp Cys Tyr Gln 
    530                 535                 540                 


Gly Asp Cys Val Pro Phe Gly Thr Trp Pro Gln Ser Ile Asp Gly Gly 
545                 550                 555                 560 


Trp Gly Pro Trp Ser Leu Trp Gly Glu Cys Ser Arg Thr Cys Gly Gly 
                565                 570                 575     


Gly Val Ser Ser Ser Leu Arg His Cys Asp Ser Pro Ala Pro Ser Gly 
            580                 585                 590         


Gly Gly Lys Tyr Cys Leu Gly Glu Arg Lys Arg Tyr Arg Ser Cys Asn 
        595                 600                 605             


Thr Asp Pro Cys Pro Leu Gly Ser Arg Asp Phe Arg Glu Lys Gln Cys 
    610                 615                 620                 


Ala Asp Phe Asp Asn Met Pro Phe Arg Gly Lys Tyr Tyr Asn Trp Lys 
625                 630                 635                 640 


Pro Tyr Thr Gly Gly Gly Val Lys Pro Cys Ala Leu Asn Cys Leu Ala 
                645                 650                 655     


Glu Gly Tyr Asn Phe Tyr Thr Glu Arg Ala Pro Ala Val Ile Asp Gly 
            660                 665                 670         


Thr Gln Cys Asn Ala Asp Ser Leu Asp Ile Cys Ile Asn Gly Glu Cys 
        675                 680                 685             


Lys His Val Gly Cys Asp Asn Ile Leu Gly Ser Asp Ala Arg Glu Asp 
    690                 695                 700                 


Arg Cys Arg Val Cys Gly Gly Asp Gly Ser Thr Cys Asp Ala Ile Glu 
705                 710                 715                 720 


Gly Phe Phe Asn Asp Ser Leu Pro Arg Gly Gly Tyr Met Glu Val Val 
                725                 730                 735     


Gln Ile Pro Arg Gly Ser Val His Ile Glu Val Arg Glu Val Ala Met 
            740                 745                 750         


Ser Lys Asn Tyr Ile Ala Leu Lys Ser Glu Gly Asp Asp Tyr Tyr Ile 
        755                 760                 765             


Asn Gly Ala Trp Thr Ile Asp Trp Pro Arg Lys Phe Asp Val Ala Gly 
    770                 775                 780                 


Thr Ala Phe His Tyr Lys Arg Pro Thr Asp Glu Pro Glu Ser Leu Glu 
785                 790                 795                 800 


Ala Leu Gly Pro Thr Ser Glu Asn Leu Ile Val Met Val Leu Leu Gln 
                805                 810                 815     


Glu Gln Asn Leu Gly Ile Arg Tyr Lys Phe Asn Val Pro Ile Thr Arg 
            820                 825                 830         


Thr Gly Ser Gly Asp Asn Glu Val Gly Phe Thr Trp Asn His Gln Pro 
        835                 840                 845             


Trp Ser Glu Cys Ser Ala Thr Cys Ala Gly Gly Val Gln Arg Gln Glu 
    850                 855                 860                 


Val Val Cys Lys Arg Leu Asp Asp Asn Ser Ile Val Gln Asn Asn Tyr 
865                 870                 875                 880 


Cys Asp Pro Asp Ser Lys Pro Pro Glu Asn Gln Arg Ala Cys Asn Thr 
                885                 890                 895     


Glu Pro Cys Pro Pro Glu Trp Phe Ile Gly Asp Trp Leu Glu Cys Ser 
            900                 905                 910         


Lys Thr Cys Asp Gly Gly Met Arg Thr Arg Ala Val Leu Cys Ile Arg 
        915                 920                 925             


Lys Ile Gly Pro Ser Glu Glu Glu Thr Leu Asp Tyr Ser Gly Cys Leu 
    930                 935                 940                 


Thr His Arg Pro Val Glu Lys Glu Pro Cys Asn Asn Gln Ser Cys Pro 
945                 950                 955                 960 


Pro Gln Trp Val Ala Leu Asp Trp Ser Glu Cys Thr Pro Lys Cys Gly 
                965                 970                 975     


Pro Gly Phe Lys His Arg Ile Val Leu Cys Lys Ser Ser Asp Leu Ser 
            980                 985                 990         


Lys Thr Phe Pro Ala Ala Gln Cys  Pro Glu Glu Ser Lys  Pro Pro Val 
        995                 1000                 1005             


Arg Ile  Arg Cys Ser Leu Gly  Arg Cys Pro Pro Pro  Arg Trp Val 
    1010                 1015                 1020             


Thr Gly  Asp Trp Gly Gln Cys  Ser Ala Gln Cys Gly  Leu Gly Gln 
    1025                 1030                 1035             


Gln Met  Arg Thr Val Gln Cys  Leu Ser Tyr Thr Gly  Gln Ala Ser 
    1040                 1045                 1050             


Ser Asp  Cys Leu Glu Thr Val  Arg Pro Pro Ser Met  Gln Gln Cys 
    1055                 1060                 1065             


Glu Ser  Lys Cys Asp Ser Thr  Pro Ile Ser Asn Thr  Glu Glu Cys 
    1070                 1075                 1080             


Lys Asp  Val Asn Lys Val Ala  Tyr Cys Pro Leu Val  Leu Lys Phe 
    1085                 1090                 1095             


Lys Phe  Cys Ser Arg Ala Tyr  Phe Arg Gln Met Cys  Cys Lys Thr 
    1100                 1105                 1110             


Cys Gln  Gly His 
    1115         


<210>  365
<211>  1686
<212>  PRT
<213>  Homo Sapiens

<400>  365

Met Pro Gly Gly Pro Ser Pro Arg Ser Pro Ala Pro Leu Leu Arg Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Cys Ala Leu Ala Pro Gly Ala Pro Gly Pro Ala 
            20                  25                  30          


Pro Gly Arg Ala Thr Glu Gly Arg Ala Ala Leu Asp Ile Val His Pro 
        35                  40                  45              


Val Arg Val Asp Ala Gly Gly Ser Phe Leu Ser Tyr Glu Leu Trp Pro 
    50                  55                  60                  


Arg Ala Leu Arg Lys Arg Asp Val Ser Val Arg Arg Asp Ala Pro Ala 
65                  70                  75                  80  


Phe Tyr Glu Leu Gln Tyr Arg Gly Arg Glu Leu Arg Phe Asn Leu Thr 
                85                  90                  95      


Ala Asn Gln His Leu Leu Ala Pro Gly Phe Val Ser Glu Thr Arg Arg 
            100                 105                 110         


Arg Gly Gly Leu Gly Arg Ala His Ile Arg Ala His Thr Pro Ala Cys 
        115                 120                 125             


His Leu Leu Gly Glu Val Gln Asp Pro Glu Leu Glu Gly Gly Leu Ala 
    130                 135                 140                 


Ala Ile Ser Ala Cys Asp Gly Leu Lys Gly Val Phe Gln Leu Ser Asn 
145                 150                 155                 160 


Glu Asp Tyr Phe Ile Glu Pro Leu Asp Ser Ala Pro Ala Arg Pro Gly 
                165                 170                 175     


His Ala Gln Pro His Val Val Tyr Lys Arg Gln Ala Pro Glu Arg Leu 
            180                 185                 190         


Ala Gln Arg Gly Asp Ser Ser Ala Pro Ser Thr Cys Gly Val Gln Val 
        195                 200                 205             


Tyr Pro Glu Leu Glu Ser Arg Arg Glu Arg Trp Glu Gln Arg Gln Gln 
    210                 215                 220                 


Trp Arg Arg Pro Arg Leu Arg Arg Leu His Gln Arg Ser Val Ser Lys 
225                 230                 235                 240 


Glu Lys Trp Val Glu Thr Leu Val Val Ala Asp Ala Lys Met Val Glu 
                245                 250                 255     


Tyr His Gly Gln Pro Gln Val Glu Ser Tyr Val Leu Thr Ile Met Asn 
            260                 265                 270         


Met Val Ala Gly Leu Phe His Asp Pro Ser Ile Gly Asn Pro Ile His 
        275                 280                 285             


Ile Thr Ile Val Arg Leu Val Leu Leu Glu Asp Glu Glu Glu Asp Leu 
    290                 295                 300                 


Lys Ile Thr His His Ala Asp Asn Thr Leu Lys Ser Phe Cys Lys Trp 
305                 310                 315                 320 


Gln Lys Ser Ile Asn Met Lys Gly Asp Ala His Pro Leu His His Asp 
                325                 330                 335     


Thr Ala Ile Leu Leu Thr Arg Lys Asp Leu Cys Ala Ala Met Asn Arg 
            340                 345                 350         


Pro Cys Glu Thr Leu Gly Leu Ser His Val Ala Gly Met Cys Gln Pro 
        355                 360                 365             


His Arg Ser Cys Ser Ile Asn Glu Asp Thr Gly Leu Pro Leu Ala Phe 
    370                 375                 380                 


Thr Val Ala His Glu Leu Gly His Ser Phe Gly Ile Gln His Asp Gly 
385                 390                 395                 400 


Ser Gly Asn Asp Cys Glu Pro Val Gly Lys Arg Pro Phe Ile Met Ser 
                405                 410                 415     


Pro Gln Leu Leu Tyr Asp Ala Ala Pro Leu Thr Trp Ser Arg Cys Ser 
            420                 425                 430         


Arg Gln Tyr Ile Thr Arg Phe Leu Asp Arg Gly Trp Gly Leu Cys Leu 
        435                 440                 445             


Asp Asp Pro Pro Ala Lys Asp Ile Ile Asp Phe Pro Ser Val Pro Pro 
    450                 455                 460                 


Gly Val Leu Tyr Asp Val Ser His Gln Cys Arg Leu Gln Tyr Gly Ala 
465                 470                 475                 480 


Tyr Ser Ala Phe Cys Glu Asp Met Asp Asn Val Cys His Thr Leu Trp 
                485                 490                 495     


Cys Ser Val Gly Thr Thr Cys His Ser Lys Leu Asp Ala Ala Val Asp 
            500                 505                 510         


Gly Thr Arg Cys Gly Glu Asn Lys Trp Cys Leu Ser Gly Glu Cys Val 
        515                 520                 525             


Pro Val Gly Phe Arg Pro Glu Ala Val Asp Gly Gly Trp Ser Gly Trp 
    530                 535                 540                 


Ser Ala Trp Ser Ile Cys Ser Arg Ser Cys Gly Met Gly Val Gln Ser 
545                 550                 555                 560 


Ala Glu Arg Gln Cys Thr Gln Pro Thr Pro Lys Tyr Lys Gly Arg Tyr 
                565                 570                 575     


Cys Val Gly Glu Arg Lys Arg Phe Arg Leu Cys Asn Leu Gln Ala Cys 
            580                 585                 590         


Pro Ala Gly Arg Pro Ser Phe Arg His Val Gln Cys Ser His Phe Asp 
        595                 600                 605             


Ala Met Leu Tyr Lys Gly Gln Leu His Thr Trp Val Pro Val Val Asn 
    610                 615                 620                 


Asp Val Asn Pro Cys Glu Leu His Cys Arg Pro Ala Asn Glu Tyr Phe 
625                 630                 635                 640 


Ala Glu Lys Leu Arg Asp Ala Val Val Asp Gly Thr Pro Cys Tyr Gln 
                645                 650                 655     


Val Arg Ala Ser Arg Asp Leu Cys Ile Asn Gly Ile Cys Lys Asn Val 
            660                 665                 670         


Gly Cys Asp Phe Glu Ile Asp Ser Gly Ala Met Glu Asp Arg Cys Gly 
        675                 680                 685             


Val Cys His Gly Asn Gly Ser Thr Cys His Thr Val Ser Gly Thr Phe 
    690                 695                 700                 


Glu Glu Ala Glu Gly Leu Gly Tyr Val Asp Val Gly Leu Ile Pro Ala 
705                 710                 715                 720 


Gly Ala Arg Glu Ile Arg Ile Gln Glu Val Ala Glu Ala Ala Asn Phe 
                725                 730                 735     


Leu Ala Leu Arg Ser Glu Asp Pro Glu Lys Tyr Phe Leu Asn Gly Gly 
            740                 745                 750         


Trp Thr Ile Gln Trp Asn Gly Asp Tyr Gln Val Ala Gly Thr Thr Phe 
        755                 760                 765             


Thr Tyr Ala Arg Arg Gly Asn Trp Glu Asn Leu Thr Ser Pro Gly Pro 
    770                 775                 780                 


Thr Lys Glu Pro Val Trp Ile Gln Leu Leu Phe Gln Glu Ser Asn Pro 
785                 790                 795                 800 


Gly Val His Tyr Glu Tyr Thr Ile His Arg Glu Ala Gly Gly His Asp 
                805                 810                 815     


Glu Val Pro Pro Pro Val Phe Ser Trp His Tyr Gly Pro Trp Thr Lys 
            820                 825                 830         


Cys Thr Val Thr Cys Gly Arg Gly Val Gln Arg Gln Asn Val Tyr Cys 
        835                 840                 845             


Leu Glu Arg Gln Ala Gly Pro Val Asp Glu Glu His Cys Asp Pro Leu 
    850                 855                 860                 


Gly Arg Pro Asp Asp Gln Gln Arg Lys Cys Ser Glu Gln Pro Cys Pro 
865                 870                 875                 880 


Ala Arg Trp Trp Ala Gly Glu Trp Gln Leu Cys Ser Ser Ser Cys Gly 
                885                 890                 895     


Pro Gly Gly Leu Ser Arg Arg Ala Val Leu Cys Ile Arg Ser Val Gly 
            900                 905                 910         


Leu Asp Glu Gln Ser Ala Leu Glu Pro Pro Ala Cys Glu His Leu Pro 
        915                 920                 925             


Arg Pro Pro Thr Glu Thr Pro Cys Asn Arg His Val Pro Cys Pro Ala 
    930                 935                 940                 


Thr Trp Ala Val Gly Asn Trp Ser Gln Cys Ser Val Thr Cys Gly Glu 
945                 950                 955                 960 


Gly Thr Gln Arg Arg Asn Val Leu Cys Thr Asn Asp Thr Gly Val Pro 
                965                 970                 975     


Cys Asp Glu Ala Gln Gln Pro Ala Ser Glu Val Thr Cys Ser Leu Pro 
            980                 985                 990         


Leu Cys Arg Trp Pro Leu Gly Thr  Leu Gly Pro Glu Gly  Ser Gly Ser 
        995                 1000                 1005             


Gly Ser  Ser Ser His Glu Leu  Phe Asn Glu Ala Asp  Phe Ile Pro 
    1010                 1015                 1020             


His His  Leu Ala Pro Arg Pro  Ser Pro Ala Ser Ser  Pro Lys Pro 
    1025                 1030                 1035             


Gly Thr  Met Gly Asn Ala Ile  Glu Glu Glu Ala Pro  Glu Leu Asp 
    1040                 1045                 1050             


Leu Pro  Gly Pro Val Phe Val  Asp Asp Phe Tyr Tyr  Asp Tyr Asn 
    1055                 1060                 1065             


Phe Ile  Asn Phe His Glu Asp  Leu Ser Tyr Gly Pro  Ser Glu Glu 
    1070                 1075                 1080             


Pro Asp  Leu Asp Leu Ala Gly  Thr Gly Asp Arg Thr  Pro Pro Pro 
    1085                 1090                 1095             


His Ser  His Pro Ala Ala Pro  Ser Thr Gly Ser Pro  Val Pro Ala 
    1100                 1105                 1110             


Thr Glu  Pro Pro Ala Ala Lys  Glu Glu Gly Val Leu  Gly Pro Trp 
    1115                 1120                 1125             


Ser Pro  Ser Pro Trp Pro Ser  Gln Ala Gly Arg Ser  Pro Pro Pro 
    1130                 1135                 1140             


Pro Ser  Glu Gln Thr Pro Gly  Asn Pro Leu Ile Asn  Phe Leu Pro 
    1145                 1150                 1155             


Glu Glu  Asp Thr Pro Ile Gly  Ala Pro Asp Leu Gly  Leu Pro Ser 
    1160                 1165                 1170             


Leu Ser  Trp Pro Arg Val Ser  Thr Asp Gly Leu Gln  Thr Pro Ala 
    1175                 1180                 1185             


Thr Pro  Glu Ser Gln Asn Asp  Phe Pro Val Gly Lys  Asp Ser Gln 
    1190                 1195                 1200             


Ser Gln  Leu Pro Pro Pro Trp  Arg Asp Arg Thr Asn  Glu Val Phe 
    1205                 1210                 1215             


Lys Asp  Asp Glu Glu Pro Lys  Gly Arg Gly Ala Pro  His Leu Pro 
    1220                 1225                 1230             


Pro Arg  Pro Ser Ser Thr Leu  Pro Pro Leu Ser Pro  Val Gly Ser 
    1235                 1240                 1245             


Thr His  Ser Ser Pro Ser Pro  Asp Val Ala Glu Leu  Trp Thr Gly 
    1250                 1255                 1260             


Gly Thr  Val Ala Trp Glu Pro  Ala Leu Glu Gly Gly  Leu Gly Pro 
    1265                 1270                 1275             


Val Asp  Ser Glu Leu Trp Pro  Thr Val Gly Val Ala  Ser Leu Leu 
    1280                 1285                 1290             


Pro Pro  Pro Ile Ala Pro Leu  Pro Glu Met Lys Val  Arg Asp Ser 
    1295                 1300                 1305             


Ser Leu  Glu Pro Gly Thr Pro  Ser Phe Pro Thr Pro  Gly Pro Gly 
    1310                 1315                 1320             


Ser Trp  Asp Leu Gln Thr Val  Ala Val Trp Gly Thr  Phe Leu Pro 
    1325                 1330                 1335             


Thr Thr  Leu Thr Gly Leu Gly  His Met Pro Glu Pro  Ala Leu Asn 
    1340                 1345                 1350             


Pro Gly  Pro Lys Gly Gln Pro  Glu Ser Leu Ser Pro  Glu Val Pro 
    1355                 1360                 1365             


Leu Ser  Ser Arg Leu Leu Ser  Thr Pro Ala Trp Asp  Ser Pro Ala 
    1370                 1375                 1380             


Asn Ser  His Arg Val Pro Glu  Thr Gln Pro Leu Ala  Pro Ser Leu 
    1385                 1390                 1395             


Ala Glu  Ala Gly Pro Pro Ala  Asp Pro Leu Val Val  Arg Asn Ala 
    1400                 1405                 1410             


Gly Trp  Gln Ala Gly Asn Trp  Ser Glu Cys Ser Thr  Thr Cys Gly 
    1415                 1420                 1425             


Leu Gly  Ala Val Trp Arg Pro  Val Arg Cys Ser Ser  Gly Arg Asp 
    1430                 1435                 1440             


Glu Asp  Cys Ala Pro Ala Gly  Arg Pro Gln Pro Ala  Arg Arg Cys 
    1445                 1450                 1455             


His Leu  Arg Pro Cys Ala Thr  Trp His Ser Gly Asn  Trp Ser Lys 
    1460                 1465                 1470             


Cys Ser  Arg Ser Cys Gly Gly  Gly Ser Ser Val Arg  Asp Val Gln 
    1475                 1480                 1485             


Cys Val  Asp Thr Arg Asp Leu  Arg Pro Leu Arg Pro  Phe His Cys 
    1490                 1495                 1500             


Gln Pro  Gly Pro Ala Lys Pro  Pro Ala His Arg Pro  Cys Gly Ala 
    1505                 1510                 1515             


Gln Pro  Cys Leu Ser Trp Tyr  Thr Ser Ser Trp Arg  Glu Cys Ser 
    1520                 1525                 1530             


Glu Ala  Cys Gly Gly Gly Glu  Gln Gln Arg Leu Val  Thr Cys Pro 
    1535                 1540                 1545             


Glu Pro  Gly Leu Cys Glu Glu  Ala Leu Arg Pro Asn  Thr Thr Arg 
    1550                 1555                 1560             


Pro Cys  Asn Thr His Pro Cys  Thr Gln Trp Val Val  Gly Pro Trp 
    1565                 1570                 1575             


Gly Gln  Cys Ser Gly Pro Cys  Gly Gly Gly Val Gln  Arg Arg Leu 
    1580                 1585                 1590             


Val Lys  Cys Val Asn Thr Gln  Thr Gly Leu Pro Glu  Glu Asp Ser 
    1595                 1600                 1605             


Asp Gln  Cys Gly His Glu Ala  Trp Pro Glu Ser Ser  Arg Pro Cys 
    1610                 1615                 1620             


Gly Thr  Glu Asp Cys Glu Pro  Val Glu Pro Pro Arg  Cys Glu Arg 
    1625                 1630                 1635             


Asp Arg  Leu Ser Phe Gly Phe  Cys Glu Thr Leu Arg  Leu Leu Gly 
    1640                 1645                 1650             


Arg Cys  Gln Leu Pro Thr Ile  Arg Thr Gln Cys Cys  Arg Ser Cys 
    1655                 1660                 1665             


Ser Pro  Pro Ser His Gly Ala  Pro Ser Arg Gly His  Gln Arg Val 
    1670                 1675                 1680             


Ala Arg  Arg 
    1685     


<210>  366
<211>  889
<212>  PRT
<213>  Homo Sapiens

<400>  366

Met Leu Pro Ala Pro Ala Ala Pro Arg Trp Pro Pro Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Pro Leu Ala Arg Gly Ala Pro Ala Arg Pro Ala 
            20                  25                  30          


Ala Gly Gly Gln Ala Ser Glu Leu Val Val Pro Thr Arg Leu Pro Gly 
        35                  40                  45              


Ser Ala Gly Glu Leu Ala Leu His Leu Ser Ala Phe Gly Lys Gly Phe 
    50                  55                  60                  


Val Leu Arg Leu Ala Pro Asp Asp Ser Phe Leu Ala Pro Glu Phe Lys 
65                  70                  75                  80  


Ile Glu Arg Leu Gly Gly Ser Gly Arg Ala Thr Gly Gly Glu Arg Gly 
                85                  90                  95      


Leu Arg Gly Cys Phe Phe Ser Gly Thr Val Asn Gly Glu Pro Glu Ser 
            100                 105                 110         


Leu Ala Ala Val Ser Leu Cys Arg Gly Leu Ser Gly Ser Phe Leu Leu 
        115                 120                 125             


Asp Gly Glu Glu Phe Thr Ile Gln Pro Gln Gly Ala Gly Gly Ser Leu 
    130                 135                 140                 


Ala Gln Pro His Arg Leu Gln Arg Trp Gly Pro Ala Gly Ala Arg Pro 
145                 150                 155                 160 


Leu Pro Arg Gly Pro Glu Trp Glu Val Glu Thr Gly Glu Gly Gln Arg 
                165                 170                 175     


Gln Glu Arg Gly Asp His Gln Glu Asp Ser Glu Glu Glu Ser Gln Glu 
            180                 185                 190         


Glu Glu Ala Glu Gly Ala Ser Glu Pro Pro Pro Pro Leu Gly Ala Thr 
        195                 200                 205             


Ser Arg Thr Lys Arg Phe Val Ser Glu Ala Arg Phe Val Glu Thr Leu 
    210                 215                 220                 


Leu Val Ala Asp Ala Ser Met Ala Ala Phe Tyr Gly Ala Asp Leu Gln 
225                 230                 235                 240 


Asn His Ile Leu Thr Leu Met Ser Val Ala Ala Arg Ile Tyr Lys His 
                245                 250                 255     


Pro Ser Ile Lys Asn Ser Ile Asn Leu Met Val Val Lys Val Leu Ile 
            260                 265                 270         


Val Glu Asp Glu Lys Trp Gly Pro Glu Val Ser Asp Asn Gly Gly Leu 
        275                 280                 285             


Thr Leu Arg Asn Phe Cys Asn Trp Gln Arg Arg Phe Asn Gln Pro Ser 
    290                 295                 300                 


Asp Arg His Pro Glu His Tyr Asp Thr Ala Ile Leu Leu Thr Arg Gln 
305                 310                 315                 320 


Asn Phe Cys Gly Gln Glu Gly Leu Cys Asp Thr Leu Gly Val Ala Asp 
                325                 330                 335     


Ile Gly Thr Ile Cys Asp Pro Asn Lys Ser Cys Ser Val Ile Glu Asp 
            340                 345                 350         


Glu Gly Leu Gln Ala Ala His Thr Leu Ala His Glu Leu Gly His Val 
        355                 360                 365             


Leu Ser Met Pro His Asp Asp Ser Lys Pro Cys Thr Arg Leu Phe Gly 
    370                 375                 380                 


Pro Met Gly Lys His His Val Met Ala Pro Leu Phe Val His Leu Asn 
385                 390                 395                 400 


Gln Thr Leu Pro Trp Ser Pro Cys Ser Ala Met Tyr Leu Thr Glu Leu 
                405                 410                 415     


Leu Asp Gly Gly His Gly Asp Cys Leu Leu Asp Ala Pro Ala Ala Ala 
            420                 425                 430         


Leu Pro Leu Pro Thr Gly Leu Pro Gly Arg Met Ala Leu Tyr Gln Leu 
        435                 440                 445             


Asp Gln Gln Cys Arg Gln Ile Phe Gly Pro Asp Phe Arg His Cys Pro 
    450                 455                 460                 


Asn Thr Ser Ala Gln Asp Val Cys Ala Gln Leu Trp Cys His Thr Asp 
465                 470                 475                 480 


Gly Ala Glu Pro Leu Cys His Thr Lys Asn Gly Ser Leu Pro Trp Ala 
                485                 490                 495     


Asp Gly Thr Pro Cys Gly Pro Gly His Leu Cys Ser Glu Gly Ser Cys 
            500                 505                 510         


Leu Pro Glu Glu Glu Val Glu Arg Pro Lys Pro Val Ala Asp Gly Gly 
        515                 520                 525             


Trp Ala Pro Trp Gly Pro Trp Gly Glu Cys Ser Arg Thr Cys Gly Gly 
    530                 535                 540                 


Gly Val Gln Phe Ser His Arg Glu Cys Lys Asp Pro Glu Pro Gln Asn 
545                 550                 555                 560 


Gly Gly Arg Tyr Cys Leu Gly Arg Arg Ala Lys Tyr Gln Ser Cys His 
                565                 570                 575     


Thr Glu Glu Cys Pro Pro Asp Gly Lys Ser Phe Arg Glu Gln Gln Cys 
            580                 585                 590         


Glu Lys Tyr Asn Ala Tyr Asn Tyr Thr Asp Met Asp Gly Asn Leu Leu 
        595                 600                 605             


Gln Trp Val Pro Lys Tyr Ala Gly Val Ser Pro Arg Asp Arg Cys Lys 
    610                 615                 620                 


Leu Phe Cys Arg Ala Arg Gly Arg Ser Glu Phe Lys Val Phe Glu Ala 
625                 630                 635                 640 


Lys Val Ile Asp Gly Thr Leu Cys Gly Pro Glu Thr Leu Ala Ile Cys 
                645                 650                 655     


Val Arg Gly Gln Cys Val Lys Ala Gly Cys Asp His Val Val Asp Ser 
            660                 665                 670         


Pro Arg Lys Leu Asp Lys Cys Gly Val Cys Gly Gly Lys Gly Asn Ser 
        675                 680                 685             


Cys Arg Lys Val Ser Gly Ser Leu Thr Pro Thr Asn Tyr Gly Tyr Asn 
    690                 695                 700                 


Asp Ile Val Thr Ile Pro Ala Gly Ala Thr Asn Ile Asp Val Lys Gln 
705                 710                 715                 720 


Arg Ser His Pro Gly Val Gln Asn Asp Gly Asn Tyr Leu Ala Leu Lys 
                725                 730                 735     


Thr Ala Asp Gly Gln Tyr Leu Leu Asn Gly Asn Leu Ala Ile Ser Ala 
            740                 745                 750         


Ile Glu Gln Asp Ile Leu Val Lys Gly Thr Ile Leu Lys Tyr Ser Gly 
        755                 760                 765             


Ser Ile Ala Thr Leu Glu Arg Leu Gln Ser Phe Arg Pro Leu Pro Glu 
    770                 775                 780                 


Pro Leu Thr Val Gln Leu Leu Thr Val Pro Gly Glu Val Phe Pro Pro 
785                 790                 795                 800 


Lys Val Lys Tyr Thr Phe Phe Val Pro Asn Asp Val Asp Phe Ser Met 
                805                 810                 815     


Gln Ser Ser Lys Glu Arg Ala Thr Thr Asn Ile Ile Gln Pro Leu Leu 
            820                 825                 830         


His Ala Gln Trp Val Leu Gly Asp Trp Ser Glu Cys Ser Ser Thr Cys 
        835                 840                 845             


Gly Ala Gly Trp Gln Arg Arg Thr Val Glu Cys Arg Asp Pro Ser Gly 
    850                 855                 860                 


Gln Ala Ser Ala Thr Cys Asn Lys Ala Leu Lys Pro Glu Asp Ala Lys 
865                 870                 875                 880 


Pro Cys Glu Ser Gln Leu Cys Pro Leu 
                885                 


<210>  367
<211>  69
<212>  PRT
<213>  Homo Sapiens

<400>  367

Ala Lys Cys Pro Gln Gly Arg Phe Ser Ile Asn Leu Tyr Gly Thr Gly 
1               5                   10                  15      


Leu Ser Leu Thr Glu Ser Ala Arg Trp Ile Ser Gln Gly Asn Tyr Ala 
            20                  25                  30          


Val Ser Asp Ile Lys Lys Ser Pro Asp Gly Thr Arg Val Val Gly Lys 
        35                  40                  45              


Cys Gly Gly Tyr Cys Gly Lys Cys Thr Pro Ser Ser Gly Thr Gly Leu 
    50                  55                  60                  


Glu Val Arg Val Leu 
65                  


<210>  368
<211>  1907
<212>  PRT
<213>  Homo Sapiens

<400>  368

Met Gln Phe Val Ser Trp Ala Thr Leu Leu Thr Leu Leu Val Arg Asp 
1               5                   10                  15      


Leu Ala Glu Met Gly Ser Pro Asp Ala Ala Ala Ala Val Arg Lys Asp 
            20                  25                  30          


Arg Leu His Pro Arg Gln Val Lys Leu Leu Glu Thr Leu Ser Glu Tyr 
        35                  40                  45              


Glu Ile Val Ser Pro Ile Arg Val Asn Ala Leu Gly Glu Pro Phe Pro 
    50                  55                  60                  


Thr Asn Val His Phe Lys Arg Thr Arg Arg Ser Ile Asn Ser Ala Thr 
65                  70                  75                  80  


Asp Pro Trp Pro Ala Phe Ala Ser Ser Ser Ser Ser Ser Thr Ser Ser 
                85                  90                  95      


Gln Ala His Tyr Arg Leu Ser Ala Phe Gly Gln Gln Phe Leu Phe Asn 
            100                 105                 110         


Leu Thr Ala Asn Ala Gly Phe Ile Ala Pro Leu Phe Thr Val Thr Leu 
        115                 120                 125             


Leu Gly Thr Pro Gly Val Asn Gln Thr Lys Phe Tyr Ser Glu Glu Glu 
    130                 135                 140                 


Ala Glu Leu Lys His Cys Phe Tyr Lys Gly Tyr Val Asn Thr Asn Ser 
145                 150                 155                 160 


Glu His Thr Ala Val Ile Ser Leu Cys Ser Gly Met Leu Gly Thr Phe 
                165                 170                 175     


Arg Ser His Asp Gly Asp Tyr Phe Ile Glu Pro Leu Gln Ser Met Asp 
            180                 185                 190         


Glu Gln Glu Asp Glu Glu Glu Gln Asn Lys Pro His Ile Ile Tyr Arg 
        195                 200                 205             


Arg Ser Ala Pro Gln Arg Glu Pro Ser Thr Gly Arg His Ala Cys Asp 
    210                 215                 220                 


Thr Ser Glu His Lys Asn Arg His Ser Lys Asp Lys Lys Lys Thr Arg 
225                 230                 235                 240 


Ala Arg Lys Trp Gly Glu Arg Ile Asn Leu Ala Gly Asp Val Ala Ala 
                245                 250                 255     


Leu Asn Ser Gly Leu Ala Thr Glu Ala Phe Ser Ala Tyr Gly Asn Lys 
            260                 265                 270         


Thr Asp Asn Thr Arg Glu Lys Arg Thr His Arg Arg Thr Lys Arg Phe 
        275                 280                 285             


Leu Ser Tyr Pro Arg Phe Val Glu Val Leu Val Val Ala Asp Asn Arg 
    290                 295                 300                 


Met Val Ser Tyr His Gly Glu Asn Leu Gln His Tyr Ile Leu Thr Leu 
305                 310                 315                 320 


Met Ser Ile Asp Gly Pro Ser Ile Ser Phe Asn Ala Gln Thr Thr Leu 
                325                 330                 335     


Lys Asn Phe Cys Gln Trp Gln His Ser Lys Asn Ser Pro Gly Gly Ile 
            340                 345                 350         


His His Asp Thr Ala Val Leu Leu Thr Arg Gln Asp Ile Cys Arg Ala 
        355                 360                 365             


His Asp Lys Cys Asp Thr Leu Gly Leu Ala Glu Leu Gly Thr Ile Cys 
    370                 375                 380                 


Asp Pro Tyr Arg Ser Cys Ser Ile Ser Glu Asp Ser Gly Leu Ser Thr 
385                 390                 395                 400 


Ala Phe Thr Ile Ala His Glu Leu Gly His Val Phe Asn Met Pro His 
                405                 410                 415     


Asp Asp Asn Asn Lys Cys Lys Glu Glu Gly Val Lys Ser Pro Gln His 
            420                 425                 430         


Val Met Ala Pro Thr Leu Asn Phe Tyr Thr Asn Pro Trp Met Trp Ser 
        435                 440                 445             


Lys Cys Ser Arg Lys Tyr Ile Thr Glu Phe Leu Asp Thr Gly Tyr Gly 
    450                 455                 460                 


Glu Cys Leu Leu Asn Glu Pro Glu Ser Arg Pro Tyr Pro Leu Pro Val 
465                 470                 475                 480 


Gln Leu Pro Gly Ile Leu Tyr Asn Val Asn Lys Gln Cys Glu Leu Ile 
                485                 490                 495     


Phe Gly Pro Gly Ser Gln Val Cys Pro Tyr Met Met Gln Cys Arg Arg 
            500                 505                 510         


Leu Trp Cys Asn Asn Val Asn Gly Val His Lys Gly Cys Arg Thr Gln 
        515                 520                 525             


His Thr Pro Trp Ala Asp Gly Thr Glu Cys Glu Pro Gly Lys His Cys 
    530                 535                 540                 


Lys Tyr Gly Phe Cys Val Pro Lys Glu Met Asp Val Pro Val Thr Asp 
545                 550                 555                 560 


Gly Ser Trp Gly Ser Trp Ser Pro Phe Gly Thr Cys Ser Arg Thr Cys 
                565                 570                 575     


Gly Gly Gly Ile Lys Thr Ala Ile Arg Glu Cys Asn Arg Pro Glu Pro 
            580                 585                 590         


Lys Asn Gly Gly Lys Tyr Cys Val Gly Arg Arg Met Lys Phe Lys Ser 
        595                 600                 605             


Cys Asn Thr Glu Pro Cys Leu Lys Gln Lys Arg Asp Phe Arg Asp Glu 
    610                 615                 620                 


Gln Cys Ala His Phe Asp Gly Lys His Phe Asn Ile Asn Gly Leu Leu 
625                 630                 635                 640 


Pro Asn Val Arg Trp Val Pro Lys Tyr Ser Gly Ile Leu Met Lys Asp 
                645                 650                 655     


Arg Cys Lys Leu Phe Cys Arg Val Ala Gly Asn Thr Ala Tyr Tyr Gln 
            660                 665                 670         


Leu Arg Asp Arg Val Ile Asp Gly Thr Pro Cys Gly Gln Asp Thr Asn 
        675                 680                 685             


Asp Ile Cys Val Gln Gly Leu Cys Arg Gln Ala Gly Cys Asp His Val 
    690                 695                 700                 


Leu Asn Ser Lys Ala Arg Arg Asp Lys Cys Gly Val Cys Gly Gly Asp 
705                 710                 715                 720 


Asn Ser Ser Cys Lys Thr Val Ala Gly Thr Phe Asn Thr Val His Tyr 
                725                 730                 735     


Gly Tyr Asn Thr Val Val Arg Ile Pro Ala Gly Ala Thr Asn Ile Asp 
            740                 745                 750         


Val Arg Gln His Ser Phe Ser Gly Glu Thr Asp Asp Asp Asn Tyr Leu 
        755                 760                 765             


Ala Leu Ser Ser Ser Lys Gly Glu Phe Leu Leu Asn Gly Asn Phe Val 
    770                 775                 780                 


Val Thr Met Ala Lys Arg Glu Ile Arg Ile Gly Asn Ala Val Val Glu 
785                 790                 795                 800 


Tyr Ser Gly Ser Glu Thr Ala Val Glu Arg Ile Asn Ser Thr Asp Arg 
                805                 810                 815     


Ile Glu Gln Glu Leu Leu Leu Gln Val Leu Ser Val Gly Lys Leu Tyr 
            820                 825                 830         


Asn Pro Asp Val Arg Tyr Ser Phe Asn Ile Pro Ile Glu Asp Lys Pro 
        835                 840                 845             


Gln Gln Phe Tyr Trp Asn Ser His Gly Pro Trp Gln Ala Cys Ser Lys 
    850                 855                 860                 


Pro Cys Gln Gly Glu Arg Lys Arg Lys Leu Val Cys Thr Arg Glu Ser 
865                 870                 875                 880 


Asp Gln Leu Thr Val Ser Asp Gln Arg Cys Asp Arg Leu Pro Gln Pro 
                885                 890                 895     


Gly His Ile Thr Glu Pro Cys Gly Thr Asp Cys Asp Leu Arg Trp His 
            900                 905                 910         


Val Ala Ser Arg Ser Glu Cys Ser Ala Gln Cys Gly Leu Gly Tyr Arg 
        915                 920                 925             


Thr Leu Asp Ile Tyr Cys Ala Lys Tyr Ser Arg Leu Asp Gly Lys Thr 
    930                 935                 940                 


Glu Lys Val Asp Asp Gly Phe Cys Ser Ser His Pro Lys Pro Ser Asn 
945                 950                 955                 960 


Arg Glu Lys Cys Ser Gly Glu Cys Asn Thr Gly Gly Trp Arg Tyr Ser 
                965                 970                 975     


Ala Trp Thr Glu Cys Ser Lys Ser Cys Asp Gly Gly Thr Gln Arg Arg 
            980                 985                 990         


Arg Ala Ile Cys Val Asn Thr Arg  Asn Asp Val Leu Asp  Asp Ser Lys 
        995                 1000                 1005             


Cys Thr  His Gln Glu Lys Val  Thr Ile Gln Arg Cys  Ser Glu Phe 
    1010                 1015                 1020             


Pro Cys  Pro Gln Trp Lys Ser  Gly Asp Trp Ser Glu  Cys Leu Val 
    1025                 1030                 1035             


Thr Cys  Gly Lys Gly His Lys  His Arg Gln Val Trp  Cys Gln Phe 
    1040                 1045                 1050             


Gly Glu  Asp Arg Leu Asn Asp  Arg Met Cys Asp Pro  Glu Thr Lys 
    1055                 1060                 1065             


Pro Thr  Ser Met Gln Thr Cys  Gln Gln Pro Glu Cys  Ala Ser Trp 
    1070                 1075                 1080             


Gln Ala  Gly Pro Trp Gly Gln  Cys Ser Val Thr Cys  Gly Gln Gly 
    1085                 1090                 1095             


Tyr Gln  Leu Arg Ala Val Lys  Cys Ile Ile Gly Thr  Tyr Met Ser 
    1100                 1105                 1110             


Val Val  Asp Asp Asn Asp Cys  Asn Ala Ala Thr Arg  Pro Thr Asp 
    1115                 1120                 1125             


Thr Gln  Asp Cys Glu Leu Pro  Ser Cys His Pro Pro  Pro Ala Ala 
    1130                 1135                 1140             


Pro Glu  Thr Arg Arg Ser Thr  Tyr Ser Ala Pro Arg  Thr Gln Trp 
    1145                 1150                 1155             


Arg Phe  Gly Ser Trp Thr Pro  Cys Ser Ala Thr Cys  Gly Lys Gly 
    1160                 1165                 1170             


Thr Arg  Met Arg Tyr Val Ser  Cys Arg Asp Glu Asn  Gly Ser Val 
    1175                 1180                 1185             


Ala Asp  Glu Ser Ala Cys Ala  Thr Leu Pro Arg Pro  Val Ala Lys 
    1190                 1195                 1200             


Glu Glu  Cys Ser Val Thr Pro  Cys Gly Gln Trp Lys  Ala Leu Asp 
    1205                 1210                 1215             


Trp Ser  Ser Cys Ser Val Thr  Cys Gly Gln Gly Arg  Ala Thr Arg 
    1220                 1225                 1230             


Gln Val  Met Cys Val Asn Tyr  Ser Asp His Val Ile  Asp Arg Ser 
    1235                 1240                 1245             


Glu Cys  Asp Gln Asp Tyr Ile  Pro Glu Thr Asp Gln  Asp Cys Ser 
    1250                 1255                 1260             


Met Ser  Pro Cys Pro Gln Arg  Thr Pro Asp Ser Gly  Leu Ala Gln 
    1265                 1270                 1275             


His Pro  Phe Gln Asn Glu Asp  Tyr Arg Pro Arg Ser  Ala Ser Pro 
    1280                 1285                 1290             


Ser Arg  Thr His Val Leu Gly  Gly Asn Gln Trp Arg  Thr Gly Pro 
    1295                 1300                 1305             


Trp Gly  Ala Cys Ser Ser Thr  Cys Ala Gly Gly Ser  Gln Arg Arg 
    1310                 1315                 1320             


Val Val  Val Cys Gln Asp Glu  Asn Gly Tyr Thr Ala  Asn Asp Cys 
    1325                 1330                 1335             


Val Glu  Arg Ile Lys Pro Asp  Glu Gln Arg Ala Cys  Glu Ser Gly 
    1340                 1345                 1350             


Pro Cys  Pro Gln Trp Ala Tyr  Gly Asn Trp Gly Glu  Cys Thr Lys 
    1355                 1360                 1365             


Leu Cys  Gly Gly Gly Ile Arg  Thr Arg Leu Val Val  Cys Gln Arg 
    1370                 1375                 1380             


Ser Asn  Gly Glu Arg Phe Pro  Asp Leu Ser Cys Glu  Ile Leu Asp 
    1385                 1390                 1395             


Lys Pro  Pro Asp Arg Glu Gln  Cys Asn Thr His Ala  Cys Pro His 
    1400                 1405                 1410             


Asp Ala  Ala Trp Ser Thr Gly  Pro Trp Ser Ser Cys  Ser Val Ser 
    1415                 1420                 1425             


Cys Gly  Arg Gly His Lys Gln  Arg Asn Val Tyr Cys  Met Ala Lys 
    1430                 1435                 1440             


Asp Gly  Ser His Leu Glu Ser  Asp Tyr Cys Lys His  Leu Ala Lys 
    1445                 1450                 1455             


Pro His  Gly His Arg Lys Cys  Arg Gly Gly Arg Cys  Pro Lys Trp 
    1460                 1465                 1470             


Lys Ala  Gly Ala Trp Ser Gln  Cys Ser Val Ser Cys  Gly Arg Gly 
    1475                 1480                 1485             


Val Gln  Gln Arg His Val Gly  Cys Gln Ile Gly Thr  His Lys Ile 
    1490                 1495                 1500             


Ala Arg  Glu Thr Glu Cys Asn  Pro Tyr Thr Arg Pro  Glu Ser Glu 
    1505                 1510                 1515             


Arg Asp  Cys Gln Gly Pro Arg  Cys Pro Leu Tyr Thr  Trp Arg Ala 
    1520                 1525                 1530             


Glu Glu  Trp Gln Glu Cys Thr  Lys Thr Cys Gly Glu  Gly Ser Arg 
    1535                 1540                 1545             


Tyr Arg  Lys Val Val Cys Val  Asp Asp Asn Lys Asn  Glu Val His 
    1550                 1555                 1560             


Gly Ala  Arg Cys Asp Val Ser  Lys Arg Pro Val Asp  Arg Glu Ser 
    1565                 1570                 1575             


Cys Ser  Leu Gln Pro Cys Glu  Tyr Val Trp Ile Thr  Gly Glu Trp 
    1580                 1585                 1590             


Ser Glu  Cys Ser Val Thr Cys  Gly Lys Gly Tyr Lys  Gln Arg Leu 
    1595                 1600                 1605             


Val Ser  Cys Ser Glu Ile Tyr  Thr Gly Lys Glu Asn  Tyr Glu Tyr 
    1610                 1615                 1620             


Ser Tyr  Gln Thr Thr Ile Asn  Cys Pro Gly Thr Gln  Pro Pro Ser 
    1625                 1630                 1635             


Val His  Pro Cys Tyr Leu Arg  Asp Cys Pro Val Ser  Ala Thr Trp 
    1640                 1645                 1650             


Arg Val  Gly Asn Trp Gly Ser  Cys Ser Val Ser Cys  Gly Val Gly 
    1655                 1660                 1665             


Val Met  Gln Arg Ser Val Gln  Cys Leu Thr Asn Glu  Asp Gln Pro 
    1670                 1675                 1680             


Ser His  Leu Cys His Thr Asp  Leu Lys Pro Glu Glu  Arg Lys Thr 
    1685                 1690                 1695             


Cys Arg  Asn Val Tyr Asn Cys  Glu Leu Pro Gln Asn  Cys Lys Glu 
    1700                 1705                 1710             


Val Lys  Arg Leu Lys Gly Ala  Ser Glu Asp Gly Glu  Tyr Phe Leu 
    1715                 1720                 1725             


Met Ile  Arg Gly Lys Leu Leu  Lys Ile Phe Cys Ala  Gly Met His 
    1730                 1735                 1740             


Ser Asp  His Pro Lys Glu Tyr  Val Thr Leu Val His  Gly Asp Ser 
    1745                 1750                 1755             


Glu Asn  Phe Ser Glu Val Tyr  Gly His Arg Leu His  Asn Pro Thr 
    1760                 1765                 1770             


Glu Cys  Pro Tyr Asn Gly Ser  Arg Arg Asp Asp Cys  Gln Cys Arg 
    1775                 1780                 1785             


Lys Asp  Tyr Thr Ala Ala Gly  Phe Ser Ser Phe Gln  Lys Ile Arg 
    1790                 1795                 1800             


Ile Asp  Leu Thr Ser Met Gln  Ile Ile Thr Thr Asp  Leu Gln Phe 
    1805                 1810                 1815             


Ala Arg  Thr Ser Glu Gly His  Pro Val Pro Phe Ala  Thr Ala Gly 
    1820                 1825                 1830             


Asp Cys  Tyr Ser Ala Ala Lys  Cys Pro Gln Gly Arg  Phe Ser Ile 
    1835                 1840                 1845             


Asn Leu  Tyr Gly Thr Gly Leu  Ser Leu Thr Glu Ser  Ala Arg Trp 
    1850                 1855                 1860             


Ile Ser  Gln Gly Asn Tyr Ala  Val Ser Asp Ile Lys  Lys Ser Pro 
    1865                 1870                 1875             


Asp Gly  Thr Arg Val Val Gly  Lys Cys Gly Gly Tyr  Cys Gly Lys 
    1880                 1885                 1890             


Cys Thr  Pro Ser Ser Gly Thr  Gly Leu Glu Val Arg  Val Leu 
    1895                 1900                 1905         


<210>  369
<211>  1935
<212>  PRT
<213>  Homo Sapiens

<400>  369

Met Gln Phe Val Ser Trp Ala Thr Leu Leu Thr Leu Leu Val Arg Asp 
1               5                   10                  15      


Leu Ala Glu Met Gly Ser Pro Asp Ala Ala Ala Ala Val Arg Lys Asp 
            20                  25                  30          


Arg Leu His Pro Arg Gln Val Lys Leu Leu Glu Thr Leu Ser Glu Tyr 
        35                  40                  45              


Glu Ile Val Ser Pro Ile Arg Val Asn Ala Leu Gly Glu Pro Phe Pro 
    50                  55                  60                  


Thr Asn Val His Phe Lys Arg Thr Arg Arg Ser Ile Asn Ser Ala Thr 
65                  70                  75                  80  


Asp Pro Trp Pro Ala Phe Ala Ser Ser Ser Ser Ser Ser Thr Ser Ser 
                85                  90                  95      


Gln Ala His Tyr Arg Leu Ser Ala Phe Gly Gln Gln Phe Leu Phe Asn 
            100                 105                 110         


Leu Thr Ala Asn Ala Gly Phe Ile Ala Pro Leu Phe Thr Val Thr Leu 
        115                 120                 125             


Leu Gly Thr Pro Gly Val Asn Gln Thr Lys Phe Tyr Ser Glu Glu Glu 
    130                 135                 140                 


Ala Glu Leu Lys His Cys Phe Tyr Lys Gly Tyr Val Asn Thr Asn Ser 
145                 150                 155                 160 


Glu His Thr Ala Val Ile Ser Leu Cys Ser Gly Met Leu Gly Thr Phe 
                165                 170                 175     


Arg Ser His Asp Gly Asp Tyr Phe Ile Glu Pro Leu Gln Ser Met Asp 
            180                 185                 190         


Glu Gln Glu Asp Glu Glu Glu Gln Asn Lys Pro His Ile Ile Tyr Arg 
        195                 200                 205             


Arg Ser Ala Pro Gln Arg Glu Pro Ser Thr Gly Arg His Ala Cys Asp 
    210                 215                 220                 


Thr Ser Glu His Lys Asn Arg His Ser Lys Asp Lys Lys Lys Thr Arg 
225                 230                 235                 240 


Ala Arg Lys Trp Gly Glu Arg Ile Asn Leu Ala Gly Asp Val Ala Ala 
                245                 250                 255     


Leu Asn Ser Gly Leu Ala Thr Glu Ala Phe Ser Ala Tyr Gly Asn Lys 
            260                 265                 270         


Thr Asp Asn Thr Arg Glu Lys Arg Thr His Arg Arg Thr Lys Arg Phe 
        275                 280                 285             


Leu Ser Tyr Pro Arg Phe Val Glu Val Leu Val Val Ala Asp Asn Arg 
    290                 295                 300                 


Met Val Ser Tyr His Gly Glu Asn Leu Gln His Tyr Ile Leu Thr Leu 
305                 310                 315                 320 


Met Ser Ile Val Ala Ser Ile Tyr Lys Asp Pro Ser Ile Gly Asn Leu 
                325                 330                 335     


Ile Asn Ile Val Ile Val Asn Leu Ile Val Ile His Asn Glu Gln Asp 
            340                 345                 350         


Gly Pro Ser Ile Ser Phe Asn Ala Gln Thr Thr Leu Lys Asn Phe Cys 
        355                 360                 365             


Gln Trp Gln His Ser Lys Asn Ser Pro Gly Gly Ile His His Asp Thr 
    370                 375                 380                 


Ala Val Leu Leu Thr Arg Gln Asp Ile Cys Arg Ala His Asp Lys Cys 
385                 390                 395                 400 


Asp Thr Leu Gly Leu Ala Glu Leu Gly Thr Ile Cys Asp Pro Tyr Arg 
                405                 410                 415     


Ser Cys Ser Ile Ser Glu Asp Ser Gly Leu Ser Thr Ala Phe Thr Ile 
            420                 425                 430         


Ala His Glu Leu Gly His Val Phe Asn Met Pro His Asp Asp Asn Asn 
        435                 440                 445             


Lys Cys Lys Glu Glu Gly Val Lys Ser Pro Gln His Val Met Ala Pro 
    450                 455                 460                 


Thr Leu Asn Phe Tyr Thr Asn Pro Trp Met Trp Ser Lys Cys Ser Arg 
465                 470                 475                 480 


Lys Tyr Ile Thr Glu Phe Leu Asp Thr Gly Tyr Gly Glu Cys Leu Leu 
                485                 490                 495     


Asn Glu Pro Glu Ser Arg Pro Tyr Pro Leu Pro Val Gln Leu Pro Gly 
            500                 505                 510         


Ile Leu Tyr Asn Val Asn Lys Gln Cys Glu Leu Ile Phe Gly Pro Gly 
        515                 520                 525             


Ser Gln Val Cys Pro Tyr Met Met Gln Cys Arg Arg Leu Trp Cys Asn 
    530                 535                 540                 


Asn Val Asn Gly Val His Lys Gly Cys Arg Thr Gln His Thr Pro Trp 
545                 550                 555                 560 


Ala Asp Gly Thr Glu Cys Glu Pro Gly Lys His Cys Lys Tyr Gly Phe 
                565                 570                 575     


Cys Val Pro Lys Glu Met Asp Val Pro Val Thr Asp Gly Ser Trp Gly 
            580                 585                 590         


Ser Trp Ser Pro Phe Gly Thr Cys Ser Arg Thr Cys Gly Gly Gly Ile 
        595                 600                 605             


Lys Thr Ala Ile Arg Glu Cys Asn Arg Pro Glu Pro Lys Asn Gly Gly 
    610                 615                 620                 


Lys Tyr Cys Val Gly Arg Arg Met Lys Phe Lys Ser Cys Asn Thr Glu 
625                 630                 635                 640 


Pro Cys Leu Lys Gln Lys Arg Asp Phe Arg Asp Glu Gln Cys Ala His 
                645                 650                 655     


Phe Asp Gly Lys His Phe Asn Ile Asn Gly Leu Leu Pro Asn Val Arg 
            660                 665                 670         


Trp Val Pro Lys Tyr Ser Gly Ile Leu Met Lys Asp Arg Cys Lys Leu 
        675                 680                 685             


Phe Cys Arg Val Ala Gly Asn Thr Ala Tyr Tyr Gln Leu Arg Asp Arg 
    690                 695                 700                 


Val Ile Asp Gly Thr Pro Cys Gly Gln Asp Thr Asn Asp Ile Cys Val 
705                 710                 715                 720 


Gln Gly Leu Cys Arg Gln Ala Gly Cys Asp His Val Leu Asn Ser Lys 
                725                 730                 735     


Ala Arg Arg Asp Lys Cys Gly Val Cys Gly Gly Asp Asn Ser Ser Cys 
            740                 745                 750         


Lys Thr Val Ala Gly Thr Phe Asn Thr Val His Tyr Gly Tyr Asn Thr 
        755                 760                 765             


Val Val Arg Ile Pro Ala Gly Ala Thr Asn Ile Asp Val Arg Gln His 
    770                 775                 780                 


Ser Phe Ser Gly Glu Thr Asp Asp Asp Asn Tyr Leu Ala Leu Ser Ser 
785                 790                 795                 800 


Ser Lys Gly Glu Phe Leu Leu Asn Gly Asn Phe Val Val Thr Met Ala 
                805                 810                 815     


Lys Arg Glu Ile Arg Ile Gly Asn Ala Val Val Glu Tyr Ser Gly Ser 
            820                 825                 830         


Glu Thr Ala Val Glu Arg Ile Asn Ser Thr Asp Arg Ile Glu Gln Glu 
        835                 840                 845             


Leu Leu Leu Gln Val Leu Ser Val Gly Lys Leu Tyr Asn Pro Asp Val 
    850                 855                 860                 


Arg Tyr Ser Phe Asn Ile Pro Ile Glu Asp Lys Pro Gln Gln Phe Tyr 
865                 870                 875                 880 


Trp Asn Ser His Gly Pro Trp Gln Ala Cys Ser Lys Pro Cys Gln Gly 
                885                 890                 895     


Glu Arg Lys Arg Lys Leu Val Cys Thr Arg Glu Ser Asp Gln Leu Thr 
            900                 905                 910         


Val Ser Asp Gln Arg Cys Asp Arg Leu Pro Gln Pro Gly His Ile Thr 
        915                 920                 925             


Glu Pro Cys Gly Thr Asp Cys Asp Leu Arg Trp His Val Ala Ser Arg 
    930                 935                 940                 


Ser Glu Cys Ser Ala Gln Cys Gly Leu Gly Tyr Arg Thr Leu Asp Ile 
945                 950                 955                 960 


Tyr Cys Ala Lys Tyr Ser Arg Leu Asp Gly Lys Thr Glu Lys Val Asp 
                965                 970                 975     


Asp Gly Phe Cys Ser Ser His Pro Lys Pro Ser Asn Arg Glu Lys Cys 
            980                 985                 990         


Ser Gly Glu Cys Asn Thr Gly Gly  Trp Arg Tyr Ser Ala  Trp Thr Glu 
        995                 1000                 1005             


Cys Ser  Lys Ser Cys Asp Gly  Gly Thr Gln Arg Arg  Arg Ala Ile 
    1010                 1015                 1020             


Cys Val  Asn Thr Arg Asn Asp  Val Leu Asp Asp Ser  Lys Cys Thr 
    1025                 1030                 1035             


His Gln  Glu Lys Val Thr Ile  Gln Arg Cys Ser Glu  Phe Pro Cys 
    1040                 1045                 1050             


Pro Gln  Trp Lys Ser Gly Asp  Trp Ser Glu Cys Leu  Val Thr Cys 
    1055                 1060                 1065             


Gly Lys  Gly His Lys His Arg  Gln Val Trp Cys Gln  Phe Gly Glu 
    1070                 1075                 1080             


Asp Arg  Leu Asn Asp Arg Met  Cys Asp Pro Glu Thr  Lys Pro Thr 
    1085                 1090                 1095             


Ser Met  Gln Thr Cys Gln Gln  Pro Glu Cys Ala Ser  Trp Gln Ala 
    1100                 1105                 1110             


Gly Pro  Trp Gly Gln Cys Ser  Val Thr Cys Gly Gln  Gly Tyr Gln 
    1115                 1120                 1125             


Leu Arg  Ala Val Lys Cys Ile  Ile Gly Thr Tyr Met  Ser Val Val 
    1130                 1135                 1140             


Asp Asp  Asn Asp Cys Asn Ala  Ala Thr Arg Pro Thr  Asp Thr Gln 
    1145                 1150                 1155             


Asp Cys  Glu Leu Pro Ser Cys  His Pro Pro Pro Ala  Ala Pro Glu 
    1160                 1165                 1170             


Thr Arg  Arg Ser Thr Tyr Ser  Ala Pro Arg Thr Gln  Trp Arg Phe 
    1175                 1180                 1185             


Gly Ser  Trp Thr Pro Cys Ser  Ala Thr Cys Gly Lys  Gly Thr Arg 
    1190                 1195                 1200             


Met Arg  Tyr Val Ser Cys Arg  Asp Glu Asn Gly Ser  Val Ala Asp 
    1205                 1210                 1215             


Glu Ser  Ala Cys Ala Thr Leu  Pro Arg Pro Val Ala  Lys Glu Glu 
    1220                 1225                 1230             


Cys Ser  Val Thr Pro Cys Gly  Gln Trp Lys Ala Leu  Asp Trp Ser 
    1235                 1240                 1245             


Ser Cys  Ser Val Thr Cys Gly  Gln Gly Arg Ala Thr  Arg Gln Val 
    1250                 1255                 1260             


Met Cys  Val Asn Tyr Ser Asp  His Val Ile Asp Arg  Ser Glu Cys 
    1265                 1270                 1275             


Asp Gln  Asp Tyr Ile Pro Glu  Thr Asp Gln Asp Cys  Ser Met Ser 
    1280                 1285                 1290             


Pro Cys  Pro Gln Arg Thr Pro  Asp Ser Gly Leu Ala  Gln His Pro 
    1295                 1300                 1305             


Phe Gln  Asn Glu Asp Tyr Arg  Pro Arg Ser Ala Ser  Pro Ser Arg 
    1310                 1315                 1320             


Thr His  Val Leu Gly Gly Asn  Gln Trp Arg Thr Gly  Pro Trp Gly 
    1325                 1330                 1335             


Ala Cys  Ser Ser Thr Cys Ala  Gly Gly Ser Gln Arg  Arg Val Val 
    1340                 1345                 1350             


Val Cys  Gln Asp Glu Asn Gly  Tyr Thr Ala Asn Asp  Cys Val Glu 
    1355                 1360                 1365             


Arg Ile  Lys Pro Asp Glu Gln  Arg Ala Cys Glu Ser  Gly Pro Cys 
    1370                 1375                 1380             


Pro Gln  Trp Ala Tyr Gly Asn  Trp Gly Glu Cys Thr  Lys Leu Cys 
    1385                 1390                 1395             


Gly Gly  Gly Ile Arg Thr Arg  Leu Val Val Cys Gln  Arg Ser Asn 
    1400                 1405                 1410             


Gly Glu  Arg Phe Pro Asp Leu  Ser Cys Glu Ile Leu  Asp Lys Pro 
    1415                 1420                 1425             


Pro Asp  Arg Glu Gln Cys Asn  Thr His Ala Cys Pro  His Asp Ala 
    1430                 1435                 1440             


Ala Trp  Ser Thr Gly Pro Trp  Ser Ser Cys Ser Val  Ser Cys Gly 
    1445                 1450                 1455             


Arg Gly  His Lys Gln Arg Asn  Val Tyr Cys Met Ala  Lys Asp Gly 
    1460                 1465                 1470             


Ser His  Leu Glu Ser Asp Tyr  Cys Lys His Leu Ala  Lys Pro His 
    1475                 1480                 1485             


Gly His  Arg Lys Cys Arg Gly  Gly Arg Cys Pro Lys  Trp Lys Ala 
    1490                 1495                 1500             


Gly Ala  Trp Ser Gln Cys Ser  Val Ser Cys Gly Arg  Gly Val Gln 
    1505                 1510                 1515             


Gln Arg  His Val Gly Cys Gln  Ile Gly Thr His Lys  Ile Ala Arg 
    1520                 1525                 1530             


Glu Thr  Glu Cys Asn Pro Tyr  Thr Arg Pro Glu Ser  Glu Arg Asp 
    1535                 1540                 1545             


Cys Gln  Gly Pro Arg Cys Pro  Leu Tyr Thr Trp Arg  Ala Glu Glu 
    1550                 1555                 1560             


Trp Gln  Glu Cys Thr Lys Thr  Cys Gly Glu Gly Ser  Arg Tyr Arg 
    1565                 1570                 1575             


Lys Val  Val Cys Val Asp Asp  Asn Lys Asn Glu Val  His Gly Ala 
    1580                 1585                 1590             


Arg Cys  Asp Val Ser Lys Arg  Pro Val Asp Arg Glu  Ser Cys Ser 
    1595                 1600                 1605             


Leu Gln  Pro Cys Glu Tyr Val  Trp Ile Thr Gly Glu  Trp Ser Glu 
    1610                 1615                 1620             


Cys Ser  Val Thr Cys Gly Lys  Gly Tyr Lys Gln Arg  Leu Val Ser 
    1625                 1630                 1635             


Cys Ser  Glu Ile Tyr Thr Gly  Lys Glu Asn Tyr Glu  Tyr Ser Tyr 
    1640                 1645                 1650             


Gln Thr  Thr Ile Asn Cys Pro  Gly Thr Gln Pro Pro  Ser Val His 
    1655                 1660                 1665             


Pro Cys  Tyr Leu Arg Asp Cys  Pro Val Ser Ala Thr  Trp Arg Val 
    1670                 1675                 1680             


Gly Asn  Trp Gly Ser Cys Ser  Val Ser Cys Gly Val  Gly Val Met 
    1685                 1690                 1695             


Gln Arg  Ser Val Gln Cys Leu  Thr Asn Glu Asp Gln  Pro Ser His 
    1700                 1705                 1710             


Leu Cys  His Thr Asp Leu Lys  Pro Glu Glu Arg Lys  Thr Cys Arg 
    1715                 1720                 1725             


Asn Val  Tyr Asn Cys Glu Leu  Pro Gln Asn Cys Lys  Glu Val Lys 
    1730                 1735                 1740             


Arg Leu  Lys Gly Ala Ser Glu  Asp Gly Glu Tyr Phe  Leu Met Ile 
    1745                 1750                 1755             


Arg Gly  Lys Leu Leu Lys Ile  Phe Cys Ala Gly Met  His Ser Asp 
    1760                 1765                 1770             


His Pro  Lys Glu Tyr Val Thr  Leu Val His Gly Asp  Ser Glu Asn 
    1775                 1780                 1785             


Phe Ser  Glu Val Tyr Gly His  Arg Leu His Asn Pro  Thr Glu Cys 
    1790                 1795                 1800             


Pro Tyr  Asn Gly Ser Arg Arg  Asp Asp Cys Gln Cys  Arg Lys Asp 
    1805                 1810                 1815             


Tyr Thr  Ala Ala Gly Phe Ser  Ser Phe Gln Lys Ile  Arg Ile Asp 
    1820                 1825                 1830             


Leu Thr  Ser Met Gln Ile Ile  Thr Thr Asp Leu Gln  Phe Ala Arg 
    1835                 1840                 1845             


Thr Ser  Glu Gly His Pro Val  Pro Phe Ala Thr Ala  Gly Asp Cys 
    1850                 1855                 1860             


Tyr Ser  Ala Ala Lys Cys Pro  Gln Gly Arg Phe Ser  Ile Asn Leu 
    1865                 1870                 1875             


Tyr Gly  Thr Gly Leu Ser Leu  Thr Glu Ser Ala Arg  Trp Ile Ser 
    1880                 1885                 1890             


Gln Gly  Asn Tyr Ala Val Ser  Asp Ile Lys Lys Ser  Pro Asp Gly 
    1895                 1900                 1905             


Thr Arg  Val Val Gly Lys Cys  Gly Gly Tyr Cys Gly  Lys Cys Thr 
    1910                 1915                 1920             


Pro Ser  Ser Gly Thr Gly Leu  Glu Val Arg Val Leu  
    1925                 1930                 1935 


<210>  370
<211>  488
<212>  PRT
<213>  Homo Sapiens

<400>  370

Met Gln Phe Val Ser Trp Ala Thr Leu Leu Thr Leu Leu Val Arg Asp 
1               5                   10                  15      


Leu Ala Glu Met Gly Ser Pro Asp Ala Ala Ala Ala Val Arg Lys Asp 
            20                  25                  30          


Arg Leu His Pro Arg Gln Val Lys Leu Leu Glu Thr Leu Ser Glu Tyr 
        35                  40                  45              


Glu Ile Val Ser Pro Ile Arg Val Asn Ala Leu Gly Glu Pro Phe Pro 
    50                  55                  60                  


Thr Asn Val His Phe Lys Arg Thr Arg Arg Ser Ile Asn Ser Ala Thr 
65                  70                  75                  80  


Asp Pro Trp Pro Ala Phe Ala Ser Ser Ser Ser Ser Ser Thr Ser Ser 
                85                  90                  95      


Gln Ala His Tyr Arg Leu Ser Ala Phe Gly Gln Gln Phe Leu Phe Asn 
            100                 105                 110         


Leu Thr Ala Asn Ala Gly Phe Ile Ala Pro Leu Phe Thr Val Thr Leu 
        115                 120                 125             


Leu Gly Thr Pro Gly Val Asn Gln Thr Lys Phe Tyr Ser Glu Glu Glu 
    130                 135                 140                 


Ala Glu Leu Lys His Cys Phe Tyr Lys Gly Tyr Val Asn Thr Asn Ser 
145                 150                 155                 160 


Glu His Thr Ala Val Ile Ser Leu Cys Ser Gly Met Leu Gly Thr Phe 
                165                 170                 175     


Arg Ser His Asp Gly Asp Tyr Phe Ile Glu Pro Leu Gln Ser Met Asp 
            180                 185                 190         


Glu Gln Glu Asp Glu Glu Glu Gln Asn Lys Pro His Ile Ile Tyr Arg 
        195                 200                 205             


Arg Ser Ala Pro Gln Arg Glu Pro Ser Thr Gly Arg His Ala Cys Asp 
    210                 215                 220                 


Thr Ser Glu His Lys Asn Arg His Ser Lys Asp Lys Lys Lys Thr Arg 
225                 230                 235                 240 


Ala Arg Lys Trp Gly Glu Arg Ile Asn Leu Ala Gly Asp Val Ala Ala 
                245                 250                 255     


Leu Asn Ser Gly Leu Ala Thr Glu Ala Phe Ser Ala Tyr Gly Asn Lys 
            260                 265                 270         


Thr Asp Asn Thr Arg Glu Lys Arg Thr His Arg Arg Thr Lys Arg Phe 
        275                 280                 285             


Leu Ser Tyr Pro Arg Phe Val Glu Val Leu Val Val Ala Asp Asn Arg 
    290                 295                 300                 


Met Val Ser Tyr His Gly Glu Asn Leu Gln His Tyr Ile Leu Thr Leu 
305                 310                 315                 320 


Met Ser Ile Val Ala Ser Ile Tyr Lys Asp Pro Ser Ile Gly Asn Leu 
                325                 330                 335     


Ile Asn Ile Val Ile Val Asn Leu Ile Val Ile His Asn Glu Gln Asp 
            340                 345                 350         


Gly Pro Ser Ile Ser Phe Asn Ala Gln Thr Thr Leu Lys Asn Phe Cys 
        355                 360                 365             


Gln Trp Gln His Ser Lys Asn Ser Pro Gly Gly Ile His His Asp Thr 
    370                 375                 380                 


Ala Val Leu Leu Thr Arg Gln Asp Ile Cys Arg Ala His Asp Lys Cys 
385                 390                 395                 400 


Asp Thr Leu Gly Leu Ala Glu Leu Gly Thr Ile Cys Asp Pro Tyr Arg 
                405                 410                 415     


Ser Cys Ser Ile Ser Glu Asp Ser Gly Leu Ser Thr Ala Phe Thr Ile 
            420                 425                 430         


Ala His Glu Leu Gly His Val Phe Asn Met Pro His Asp Asp Asn Asn 
        435                 440                 445             


Lys Cys Lys Glu Glu Gly Val Lys Ser Pro Gln His Val Met Ala Pro 
    450                 455                 460                 


Thr Leu Asn Phe Tyr Thr Asn Pro Trp Met Trp Ser Lys Cys Ser Arg 
465                 470                 475                 480 


Lys Tyr Ile Thr Glu Phe Leu Glu 
                485             


<210>  371
<211>  991
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  371

Xaa Glu Cys Ser Ala Gln Cys Gly Leu Gly Tyr Arg Thr Leu Asp Ile 
1               5                   10                  15      


Tyr Cys Ala Lys Tyr Ser Arg Leu Asp Gly Lys Thr Glu Lys Val Asp 
            20                  25                  30          


Asp Gly Phe Cys Ser Ser His Pro Lys Pro Ser Asn Arg Glu Lys Cys 
        35                  40                  45              


Ser Gly Glu Cys Asn Thr Gly Gly Trp Arg Tyr Ser Ala Trp Thr Glu 
    50                  55                  60                  


Cys Ser Lys Ser Cys Asp Gly Gly Thr Gln Arg Arg Arg Ala Ile Cys 
65                  70                  75                  80  


Val Asn Thr Arg Asn Asp Val Leu Asp Asp Ser Lys Cys Thr His Gln 
                85                  90                  95      


Glu Lys Val Thr Ile Gln Arg Cys Ser Glu Phe Pro Cys Pro Gln Trp 
            100                 105                 110         


Lys Ser Gly Asp Trp Ser Glu Cys Leu Val Thr Cys Gly Lys Gly His 
        115                 120                 125             


Lys His Arg Gln Val Trp Cys Gln Phe Gly Glu Asp Arg Leu Asn Asp 
    130                 135                 140                 


Arg Met Cys Asp Pro Glu Thr Lys Pro Thr Ser Met Gln Thr Cys Gln 
145                 150                 155                 160 


Gln Pro Glu Cys Ala Ser Trp Gln Ala Gly Pro Trp Gly Gln Cys Ser 
                165                 170                 175     


Val Thr Cys Gly Gln Gly Tyr Gln Leu Arg Ala Val Lys Cys Ile Ile 
            180                 185                 190         


Gly Thr Tyr Met Ser Val Val Asp Asp Asn Asp Cys Asn Ala Ala Thr 
        195                 200                 205             


Arg Pro Thr Asp Thr Gln Asp Cys Glu Leu Pro Ser Cys His Pro Pro 
    210                 215                 220                 


Pro Ala Ala Pro Glu Thr Arg Arg Ser Thr Tyr Ser Ala Pro Arg Thr 
225                 230                 235                 240 


Gln Trp Arg Phe Gly Ser Trp Thr Pro Cys Ser Ala Thr Cys Gly Lys 
                245                 250                 255     


Gly Thr Arg Met Arg Tyr Val Ser Cys Arg Asp Glu Asn Gly Ser Val 
            260                 265                 270         


Ala Asp Glu Ser Ala Cys Ala Thr Leu Pro Arg Pro Val Ala Lys Glu 
        275                 280                 285             


Glu Cys Ser Val Thr Pro Cys Gly Gln Trp Lys Ala Leu Asp Trp Ser 
    290                 295                 300                 


Ser Cys Ser Val Thr Cys Gly Gln Gly Arg Ala Thr Arg Gln Val Met 
305                 310                 315                 320 


Cys Val Asn Tyr Ser Asp His Val Ile Asp Arg Ser Glu Cys Asp Gln 
                325                 330                 335     


Asp Tyr Ile Pro Glu Thr Asp Gln Asp Cys Ser Met Ser Pro Cys Pro 
            340                 345                 350         


Gln Arg Thr Pro Asp Ser Gly Leu Ala Gln His Pro Phe Gln Asn Glu 
        355                 360                 365             


Asp Tyr Arg Pro Arg Ser Ala Ser Pro Ser Arg Thr His Val Leu Gly 
    370                 375                 380                 


Gly Asn Gln Trp Arg Thr Gly Pro Trp Gly Ala Cys Ser Ser Thr Cys 
385                 390                 395                 400 


Ala Gly Gly Ser Gln Arg Arg Val Val Val Cys Gln Asp Glu Asn Gly 
                405                 410                 415     


Tyr Thr Ala Asn Asp Cys Val Glu Arg Ile Lys Pro Asp Glu Gln Arg 
            420                 425                 430         


Ala Cys Glu Ser Gly Pro Cys Pro Gln Trp Ala Tyr Gly Asn Trp Gly 
        435                 440                 445             


Glu Cys Thr Lys Leu Cys Gly Gly Gly Ile Arg Thr Arg Leu Val Val 
    450                 455                 460                 


Cys Gln Arg Ser Asn Gly Glu Arg Phe Pro Asp Leu Ser Cys Glu Ile 
465                 470                 475                 480 


Leu Asp Lys Pro Pro Asp Arg Glu Gln Cys Asn Thr His Ala Cys Pro 
                485                 490                 495     


His Asp Ala Ala Trp Ser Thr Gly Pro Trp Ser Ser Cys Ser Val Ser 
            500                 505                 510         


Cys Gly Arg Gly His Lys Gln Arg Asn Val Tyr Cys Met Ala Lys Asp 
        515                 520                 525             


Gly Ser His Leu Glu Ser Asp Tyr Cys Lys His Leu Ala Lys Pro His 
    530                 535                 540                 


Gly His Arg Lys Cys Arg Gly Gly Arg Cys Pro Lys Trp Lys Ala Gly 
545                 550                 555                 560 


Ala Trp Ser Gln Cys Ser Val Ser Cys Gly Arg Gly Val Gln Gln Arg 
                565                 570                 575     


His Val Gly Cys Gln Ile Gly Thr His Lys Ile Ala Arg Glu Thr Glu 
            580                 585                 590         


Cys Asn Pro Tyr Thr Arg Pro Glu Ser Glu Arg Asp Cys Gln Gly Pro 
        595                 600                 605             


Arg Cys Pro Leu Tyr Thr Trp Arg Ala Glu Glu Trp Gln Glu Cys Thr 
    610                 615                 620                 


Lys Thr Cys Gly Glu Gly Ser Arg Tyr Arg Lys Val Val Cys Val Asp 
625                 630                 635                 640 


Asp Asn Lys Asn Glu Val His Gly Ala Arg Cys Asp Val Ser Lys Arg 
                645                 650                 655     


Pro Val Asp Arg Glu Ser Cys Ser Leu Gln Pro Cys Glu Tyr Val Trp 
            660                 665                 670         


Ile Thr Gly Glu Trp Ser Glu Cys Ser Val Thr Cys Gly Lys Gly Tyr 
        675                 680                 685             


Lys Gln Arg Leu Val Ser Cys Ser Glu Ile Tyr Thr Gly Lys Glu Asn 
    690                 695                 700                 


Tyr Glu Tyr Ser Tyr Gln Thr Thr Ile Asn Cys Pro Gly Thr Gln Pro 
705                 710                 715                 720 


Pro Ser Val His Pro Cys Tyr Leu Arg Asp Cys Pro Val Ser Ala Thr 
                725                 730                 735     


Trp Arg Val Gly Asn Trp Gly Ser Cys Ser Val Ser Cys Gly Val Gly 
            740                 745                 750         


Val Met Gln Arg Ser Val Gln Cys Leu Thr Asn Glu Asp Gln Pro Ser 
        755                 760                 765             


His Leu Cys His Thr Asp Leu Lys Pro Glu Glu Arg Lys Thr Cys Arg 
    770                 775                 780                 


Asn Val Tyr Asn Cys Glu Leu Pro Gln Asn Cys Lys Glu Val Lys Arg 
785                 790                 795                 800 


Leu Lys Gly Ala Ser Glu Asp Gly Glu Tyr Phe Leu Met Ile Arg Gly 
                805                 810                 815     


Lys Leu Leu Lys Ile Phe Cys Ala Gly Met His Ser Asp His Pro Lys 
            820                 825                 830         


Glu Tyr Val Thr Leu Val His Gly Asp Ser Glu Asn Phe Ser Glu Val 
        835                 840                 845             


Tyr Gly His Arg Leu His Asn Pro Thr Glu Cys Pro Tyr Asn Gly Ser 
    850                 855                 860                 


Arg Arg Asp Asp Cys Gln Cys Arg Lys Asp Tyr Thr Ala Ala Gly Phe 
865                 870                 875                 880 


Ser Ser Phe Gln Lys Ile Arg Ile Asp Leu Thr Ser Met Gln Ile Ile 
                885                 890                 895     


Thr Thr Asp Leu Gln Phe Ala Arg Thr Ser Glu Gly His Pro Val Pro 
            900                 905                 910         


Phe Ala Thr Ala Gly Asp Cys Tyr Ser Ala Ala Lys Cys Pro Gln Gly 
        915                 920                 925             


Arg Phe Ser Ile Asn Leu Tyr Gly Thr Gly Leu Ser Leu Thr Glu Ser 
    930                 935                 940                 


Ala Arg Trp Ile Ser Gln Gly Asn Tyr Ala Val Ser Asp Ile Lys Lys 
945                 950                 955                 960 


Ser Pro Asp Gly Thr Arg Val Val Gly Lys Cys Gly Gly Tyr Cys Gly 
                965                 970                 975     


Lys Cys Thr Pro Ser Ser Gly Thr Gly Leu Glu Val Arg Val Leu 
            980                 985                 990     


<210>  372
<211>  127
<212>  PRT
<213>  Homo Sapiens

<400>  372

Met Ala Arg Leu Glu Ala Pro Gln Cys Pro Gly Phe Leu Ala Arg Leu 
1               5                   10                  15      


Leu Gly Gly Thr Trp Cys Leu Leu Cys Ile Ala Gly Gln Val Cys Gly 
            20                  25                  30          


Asp Gln Ser Gln Gly Ala Val Phe Leu Arg Glu Phe Thr Leu Ile Arg 
        35                  40                  45              


Arg Glu Ser Leu His Glu Asp Phe Leu Ser Asp Leu Leu Asn Ser His 
    50                  55                  60                  


Lys Thr Glu Asp Ser Ser Ser Arg Thr Ala Arg Ser Glu Glu Asp Arg 
65                  70                  75                  80  


Asp Gly Leu Trp Asp Ala Trp Gly Pro Trp Ser Glu Cys Ser Arg Thr 
                85                  90                  95      


Cys Gly Gly Gly Ala Ser Tyr Ser Leu Arg Arg Cys Leu Ser Ser Lys 
            100                 105                 110         


Ser Cys Glu Gly Arg Asn Ile Arg Tyr Arg Thr Cys Ser Asn Val 
        115                 120                 125         


<210>  373
<211>  219
<212>  PRT
<213>  Homo Sapiens

<400>  373

Met Glu Cys Cys Arg Arg Ala Thr Pro Gly Thr Leu Leu Leu Phe Leu 
1               5                   10                  15      


Ala Phe Leu Leu Leu Ser Ser Arg Thr Ala Arg Ser Glu Glu Asp Arg 
            20                  25                  30          


Asp Gly Leu Trp Asp Ala Trp Gly Pro Trp Ser Glu Cys Ser Arg Thr 
        35                  40                  45              


Cys Gly Gly Gly Ala Ser Tyr Ser Leu Arg Arg Cys Leu Ser Ser Lys 
    50                  55                  60                  


Ser Cys Glu Gly Arg Asn Ile Arg Tyr Arg Thr Cys Ser Asn Val Asp 
65                  70                  75                  80  


Cys Pro Pro Glu Ala Gly Asp Phe Arg Ala Gln Gln Cys Ser Ala His 
                85                  90                  95      


Asn Asp Val Lys His His Gly Gln Phe Tyr Glu Trp Leu Pro Val Ser 
            100                 105                 110         


Asn Asp Pro Asp Asn Pro Cys Ser Leu Lys Cys Gln Ala Lys Gly Thr 
        115                 120                 125             


Thr Leu Val Val Glu Leu Ala Pro Lys Val Leu Asp Gly Thr Arg Cys 
    130                 135                 140                 


Tyr Thr Glu Ser Leu Asp Met Cys Ile Ser Gly Leu Cys Gln Ile Val 
145                 150                 155                 160 


Gly Cys Asp His Gln Leu Gly Ser Thr Val Lys Glu Asp Asn Cys Gly 
                165                 170                 175     


Val Cys Asn Gly Asp Gly Ser Thr Cys Arg Leu Val Arg Gly Gln Tyr 
            180                 185                 190         


Lys Ser Gln Leu Ser Ala Thr Lys Cys Lys Thr His Arg Asp Gly Arg 
        195                 200                 205             


Pro Leu Asp Leu Leu Thr Tyr Pro Leu Leu Ala 
    210                 215                 


<210>  374
<211>  683
<212>  PRT
<213>  Homo Sapiens

<400>  374

Met Glu Cys Cys Arg Arg Ala Thr Pro Gly Thr Leu Leu Leu Phe Leu 
1               5                   10                  15      


Ala Phe Leu Leu Leu Ser Ser Arg Thr Ala Arg Ser Glu Glu Asp Arg 
            20                  25                  30          


Asp Gly Leu Trp Asp Ala Trp Gly Pro Trp Ser Glu Cys Ser Arg Thr 
        35                  40                  45              


Cys Gly Gly Gly Ala Ser Tyr Ser Leu Arg Arg Cys Leu Ser Ser Lys 
    50                  55                  60                  


Ser Cys Glu Gly Arg Asn Ile Arg Tyr Arg Thr Cys Ser Asn Val Asp 
65                  70                  75                  80  


Cys Pro Pro Glu Ala Gly Asp Phe Arg Ala Gln Gln Cys Ser Ala His 
                85                  90                  95      


Asn Asp Val Lys His His Gly Gln Phe Tyr Glu Trp Leu Pro Val Ser 
            100                 105                 110         


Asn Asp Pro Asp Asn Pro Cys Ser Leu Lys Cys Gln Ala Lys Gly Thr 
        115                 120                 125             


Thr Leu Val Val Glu Leu Ala Pro Lys Val Leu Asp Gly Thr Arg Cys 
    130                 135                 140                 


Tyr Thr Glu Ser Leu Asp Met Cys Ile Ser Gly Leu Cys Gln Ile Val 
145                 150                 155                 160 


Gly Cys Asp His Gln Leu Gly Ser Thr Val Lys Glu Asp Asn Cys Gly 
                165                 170                 175     


Val Cys Asn Gly Asp Gly Ser Thr Cys Arg Leu Val Arg Gly Gln Tyr 
            180                 185                 190         


Lys Ser Gln Leu Ser Ala Thr Lys Ser Asp Asp Thr Val Val Ala Ile 
        195                 200                 205             


Pro Tyr Gly Ser Arg His Ile Arg Leu Val Leu Lys Gly Pro Asp His 
    210                 215                 220                 


Leu Tyr Leu Glu Thr Lys Thr Leu Gln Gly Thr Lys Gly Glu Asn Ser 
225                 230                 235                 240 


Leu Ser Ser Thr Gly Thr Phe Leu Val Asp Asn Ser Ser Val Asp Phe 
                245                 250                 255     


Gln Lys Phe Pro Asp Lys Glu Ile Leu Arg Met Ala Gly Pro Leu Thr 
            260                 265                 270         


Ala Asp Phe Ile Val Lys Ile Arg Asn Ser Gly Ser Ala Asp Ser Thr 
        275                 280                 285             


Val Gln Phe Ile Phe Tyr Gln Pro Ile Ile His Arg Trp Arg Glu Thr 
    290                 295                 300                 


Asp Phe Phe Pro Cys Ser Ala Thr Cys Gly Gly Gly Tyr Gln Leu Thr 
305                 310                 315                 320 


Ser Ala Glu Cys Tyr Asp Leu Arg Ser Asn Arg Val Val Ala Asp Gln 
                325                 330                 335     


Tyr Cys His Tyr Tyr Pro Glu Asn Ile Lys Pro Lys Pro Lys Leu Gln 
            340                 345                 350         


Glu Cys Asn Leu Asp Pro Cys Pro Ala Ser Asp Gly Tyr Lys Gln Ile 
        355                 360                 365             


Met Pro Tyr Asp Leu Tyr His Pro Leu Pro Arg Trp Glu Ala Thr Pro 
    370                 375                 380                 


Trp Thr Ala Cys Ser Ser Ser Cys Gly Gly Gly Ile Gln Ser Arg Ala 
385                 390                 395                 400 


Val Ser Cys Val Glu Glu Asp Ile Gln Gly His Val Thr Ser Val Glu 
                405                 410                 415     


Glu Trp Lys Cys Met Tyr Thr Pro Lys Met Pro Ile Ala Gln Pro Cys 
            420                 425                 430         


Asn Ile Phe Asp Cys Pro Lys Trp Leu Ala Gln Glu Trp Ser Pro Cys 
        435                 440                 445             


Thr Val Thr Cys Gly Gln Gly Leu Arg Tyr Arg Val Val Leu Cys Ile 
    450                 455                 460                 


Asp His Arg Gly Met His Thr Gly Gly Cys Ser Pro Lys Thr Lys Pro 
465                 470                 475                 480 


His Ile Lys Glu Glu Cys Ile Val Pro Thr Pro Cys Tyr Lys Pro Lys 
                485                 490                 495     


Glu Lys Leu Pro Val Glu Ala Lys Leu Pro Trp Phe Lys Gln Ala Gln 
            500                 505                 510         


Glu Leu Glu Glu Gly Ala Ala Val Ser Glu Glu Pro Ser Phe Ile Pro 
        515                 520                 525             


Glu Ala Trp Ser Ala Cys Thr Val Thr Cys Gly Val Gly Thr Gln Val 
    530                 535                 540                 


Arg Ile Val Arg Cys Gln Val Leu Leu Ser Phe Ser Gln Ser Val Ala 
545                 550                 555                 560 


Asp Leu Pro Ile Asp Glu Cys Glu Gly Pro Lys Pro Ala Ser Gln Arg 
                565                 570                 575     


Ala Cys Tyr Ala Gly Pro Cys Ser Gly Glu Ile Pro Glu Phe Asn Pro 
            580                 585                 590         


Asp Glu Thr Asp Gly Leu Phe Gly Gly Leu Gln Asp Phe Asp Glu Leu 
        595                 600                 605             


Tyr Asp Trp Glu Tyr Glu Gly Phe Thr Lys Cys Ser Glu Ser Cys Gly 
    610                 615                 620                 


Gly Gly Val Gln Glu Ala Val Val Ser Cys Leu Asn Lys Gln Thr Arg 
625                 630                 635                 640 


Glu Pro Ala Glu Glu Asn Leu Cys Val Thr Ser Arg Arg Pro Pro Gln 
                645                 650                 655     


Leu Leu Lys Ser Cys Asn Leu Asp Pro Cys Pro Ala Arg Ser Ser Ile 
            660                 665                 670         


Asp Ser Ala Trp Asn Ala Cys Asn Val Leu Cys 
        675                 680             


<210>  375
<211>  525
<212>  PRT
<213>  Homo Sapiens

<400>  375

Met Glu Cys Cys Arg Arg Ala Thr Pro Gly Thr Leu Leu Leu Phe Leu 
1               5                   10                  15      


Ala Phe Leu Leu Leu Ser Ser Arg Thr Ala Arg Ser Glu Glu Asp Arg 
            20                  25                  30          


Asp Gly Leu Trp Asp Ala Trp Gly Pro Trp Ser Glu Cys Ser Arg Thr 
        35                  40                  45              


Cys Gly Gly Gly Ala Ser Tyr Ser Leu Arg Arg Cys Leu Ser Ser Lys 
    50                  55                  60                  


Ser Cys Glu Gly Arg Asn Ile Arg Tyr Arg Thr Cys Ser Asn Val Asp 
65                  70                  75                  80  


Cys Pro Pro Glu Ala Gly Asp Phe Arg Ala Gln Gln Cys Ser Ala His 
                85                  90                  95      


Asn Asp Val Lys His His Gly Gln Phe Tyr Glu Trp Leu Pro Val Ser 
            100                 105                 110         


Asn Asp Pro Asp Asn Pro Cys Ser Leu Lys Cys Gln Ala Lys Gly Thr 
        115                 120                 125             


Thr Leu Val Val Glu Leu Ala Pro Lys Val Leu Asp Gly Thr Arg Cys 
    130                 135                 140                 


Tyr Thr Glu Ser Leu Asp Met Cys Ile Ser Gly Leu Cys Gln Ile Val 
145                 150                 155                 160 


Gly Cys Asp His Gln Leu Gly Ser Thr Val Lys Glu Asp Asn Cys Gly 
                165                 170                 175     


Val Cys Asn Gly Asp Gly Ser Thr Cys Arg Leu Val Arg Gly Gln Tyr 
            180                 185                 190         


Lys Ser Gln Leu Ser Ala Thr Lys Ser Asp Asp Thr Val Val Ala Ile 
        195                 200                 205             


Pro Tyr Gly Ser Arg His Ile Arg Leu Val Leu Lys Gly Pro Asp His 
    210                 215                 220                 


Leu Tyr Leu Glu Thr Lys Thr Leu Gln Gly Thr Lys Gly Glu Asn Ser 
225                 230                 235                 240 


Leu Ser Ser Thr Gly Thr Phe Leu Val Asp Asn Ser Ser Val Asp Phe 
                245                 250                 255     


Gln Lys Phe Pro Asp Lys Glu Ile Leu Arg Met Ala Gly Pro Leu Thr 
            260                 265                 270         


Ala Asp Phe Ile Val Lys Ile Arg Asn Ser Gly Ser Ala Asp Ser Thr 
        275                 280                 285             


Val Gln Phe Ile Phe Tyr Gln Pro Ile Ile His Arg Trp Arg Glu Thr 
    290                 295                 300                 


Asp Phe Phe Pro Cys Ser Ala Thr Cys Gly Gly Gly Tyr Gln Leu Thr 
305                 310                 315                 320 


Ser Ala Glu Cys Tyr Asp Leu Arg Ser Asn Arg Val Val Ala Asp Gln 
                325                 330                 335     


Tyr Cys His Tyr Tyr Pro Glu Asn Ile Lys Pro Lys Pro Lys Leu Gln 
            340                 345                 350         


Glu Cys Asn Leu Asp Pro Cys Pro Ala Ser Asp Gly Tyr Lys Gln Ile 
        355                 360                 365             


Met Pro Tyr Asp Leu Tyr His Pro Leu Pro Arg Trp Glu Ala Thr Pro 
    370                 375                 380                 


Trp Thr Ala Cys Ser Ser Ser Cys Gly Gly Gly Ile Gln Ser Arg Ala 
385                 390                 395                 400 


Val Ser Cys Val Glu Glu Asp Ile Gln Gly His Val Thr Ser Val Glu 
                405                 410                 415     


Glu Trp Lys Cys Met Tyr Thr Pro Lys Met Pro Ile Ala Gln Pro Cys 
            420                 425                 430         


Asn Ile Phe Asp Cys Pro Lys Trp Leu Ala Gln Glu Trp Ser Pro Cys 
        435                 440                 445             


Thr Val Thr Cys Gly Gln Gly Leu Arg Tyr Arg Val Val Leu Cys Ile 
    450                 455                 460                 


Asp His Arg Gly Met His Thr Gly Gly Cys Ser Pro Lys Thr Lys Pro 
465                 470                 475                 480 


His Ile Lys Glu Glu Cys Ile Val Pro Thr Pro Cys Tyr Lys Pro Lys 
                485                 490                 495     


Glu Lys Leu Pro Val Glu Ala Lys Leu Pro Trp Phe Lys Gln Ala Gln 
            500                 505                 510         


Glu Leu Glu Glu Gly Ala Ala Val Ser Glu Glu Pro Ser 
        515                 520                 525 


<210>  376
<211>  1762
<212>  PRT
<213>  Homo Sapiens

<400>  376

Met Glu Cys Cys Arg Arg Ala Thr Pro Gly Thr Leu Leu Leu Phe Leu 
1               5                   10                  15      


Ala Phe Leu Leu Leu Ser Ser Arg Thr Ala Arg Ser Glu Glu Asp Arg 
            20                  25                  30          


Asp Gly Leu Trp Asp Ala Trp Gly Pro Trp Ser Glu Cys Ser Arg Thr 
        35                  40                  45              


Cys Gly Gly Gly Ala Ser Tyr Ser Leu Arg Arg Cys Leu Ser Ser Lys 
    50                  55                  60                  


Ser Cys Glu Gly Arg Asn Ile Arg Tyr Arg Thr Cys Ser Asn Val Asp 
65                  70                  75                  80  


Cys Pro Pro Glu Ala Gly Asp Phe Arg Ala Gln Gln Cys Ser Ala His 
                85                  90                  95      


Asn Asp Val Lys His His Gly Gln Phe Tyr Glu Trp Leu Pro Val Ser 
            100                 105                 110         


Asn Asp Pro Asp Asn Pro Cys Ser Leu Lys Cys Gln Ala Lys Gly Thr 
        115                 120                 125             


Thr Leu Val Val Glu Leu Ala Pro Lys Val Leu Asp Gly Thr Arg Cys 
    130                 135                 140                 


Tyr Thr Glu Ser Leu Asp Met Cys Ile Ser Gly Leu Cys Gln Ile Val 
145                 150                 155                 160 


Gly Cys Asp His Gln Leu Gly Ser Thr Val Lys Glu Asp Asn Cys Gly 
                165                 170                 175     


Val Cys Asn Gly Asp Gly Ser Thr Cys Arg Leu Val Arg Gly Gln Tyr 
            180                 185                 190         


Lys Ser Gln Leu Ser Ala Thr Lys Ser Asp Asp Thr Val Val Ala Ile 
        195                 200                 205             


Pro Tyr Gly Ser Arg His Ile Arg Leu Val Leu Lys Gly Pro Asp His 
    210                 215                 220                 


Leu Tyr Leu Glu Thr Lys Thr Leu Gln Gly Thr Lys Gly Glu Asn Ser 
225                 230                 235                 240 


Leu Ser Ser Thr Gly Thr Phe Leu Val Asp Asn Ser Ser Val Asp Phe 
                245                 250                 255     


Gln Lys Phe Pro Asp Lys Glu Ile Leu Arg Met Ala Gly Pro Leu Thr 
            260                 265                 270         


Ala Asp Phe Ile Val Lys Ile Arg Asn Ser Gly Ser Ala Asp Ser Thr 
        275                 280                 285             


Val Gln Phe Ile Phe Tyr Gln Pro Ile Ile His Arg Trp Arg Glu Thr 
    290                 295                 300                 


Asp Phe Phe Pro Cys Ser Ala Thr Cys Gly Gly Gly Tyr Gln Leu Thr 
305                 310                 315                 320 


Ser Ala Glu Cys Tyr Asp Leu Arg Ser Asn Arg Val Val Ala Asp Gln 
                325                 330                 335     


Tyr Cys His Tyr Tyr Pro Glu Asn Ile Lys Pro Lys Pro Lys Leu Gln 
            340                 345                 350         


Glu Cys Asn Leu Asp Pro Cys Pro Ala Ser Asp Gly Tyr Lys Gln Ile 
        355                 360                 365             


Met Pro Tyr Asp Leu Tyr His Pro Leu Pro Arg Trp Glu Ala Thr Pro 
    370                 375                 380                 


Trp Thr Ala Cys Ser Ser Ser Cys Gly Gly Gly Ile Gln Ser Arg Ala 
385                 390                 395                 400 


Val Ser Cys Val Glu Glu Asp Ile Gln Gly His Val Thr Ser Val Glu 
                405                 410                 415     


Glu Trp Lys Cys Met Tyr Thr Pro Lys Met Pro Ile Ala Gln Pro Cys 
            420                 425                 430         


Asn Ile Phe Asp Cys Pro Lys Trp Leu Ala Gln Glu Trp Ser Pro Cys 
        435                 440                 445             


Thr Val Thr Cys Gly Gln Gly Leu Arg Tyr Arg Val Val Leu Cys Ile 
    450                 455                 460                 


Asp His Arg Gly Met His Thr Gly Gly Cys Ser Pro Lys Thr Lys Pro 
465                 470                 475                 480 


His Ile Lys Glu Glu Cys Ile Val Pro Thr Pro Cys Tyr Lys Pro Lys 
                485                 490                 495     


Glu Lys Leu Pro Val Glu Ala Lys Leu Pro Trp Phe Lys Gln Ala Gln 
            500                 505                 510         


Glu Leu Glu Glu Gly Ala Ala Val Ser Glu Glu Pro Ser Phe Ile Pro 
        515                 520                 525             


Glu Ala Trp Ser Ala Cys Thr Val Thr Cys Gly Val Gly Thr Gln Val 
    530                 535                 540                 


Arg Ile Val Arg Cys Gln Val Leu Leu Ser Phe Ser Gln Ser Val Ala 
545                 550                 555                 560 


Asp Leu Pro Ile Asp Glu Cys Glu Gly Pro Lys Pro Ala Ser Gln Arg 
                565                 570                 575     


Ala Cys Tyr Ala Gly Pro Cys Ser Gly Glu Ile Pro Glu Phe Asn Pro 
            580                 585                 590         


Asp Glu Thr Asp Gly Leu Phe Gly Gly Leu Gln Asp Phe Asp Glu Leu 
        595                 600                 605             


Tyr Asp Trp Glu Tyr Glu Gly Phe Thr Lys Cys Ser Glu Ser Cys Gly 
    610                 615                 620                 


Gly Gly Val Gln Glu Ala Val Val Ser Cys Leu Asn Lys Gln Thr Arg 
625                 630                 635                 640 


Glu Pro Ala Glu Glu Asn Leu Cys Val Thr Ser Arg Arg Pro Pro Gln 
                645                 650                 655     


Leu Leu Lys Ser Cys Asn Leu Asp Pro Cys Pro Ala Arg Trp Glu Ile 
            660                 665                 670         


Gly Lys Trp Ser Pro Cys Ser Leu Thr Cys Gly Val Gly Leu Gln Thr 
        675                 680                 685             


Arg Asp Val Phe Cys Ser His Leu Leu Ser Arg Glu Met Asn Glu Thr 
    690                 695                 700                 


Val Ile Leu Ala Asp Glu Leu Cys Arg Gln Pro Lys Pro Ser Thr Val 
705                 710                 715                 720 


Gln Ala Cys Asn Arg Phe Asn Cys Pro Pro Ala Trp Tyr Pro Ala Gln 
                725                 730                 735     


Trp Gln Pro Cys Ser Arg Thr Cys Gly Gly Gly Val Gln Lys Arg Glu 
            740                 745                 750         


Val Leu Cys Lys Gln Arg Met Ala Asp Gly Ser Phe Leu Glu Leu Pro 
        755                 760                 765             


Glu Thr Phe Cys Ser Ala Ser Lys Pro Ala Cys Gln Gln Ala Cys Lys 
    770                 775                 780                 


Lys Asp Asp Cys Pro Ser Glu Trp Leu Leu Ser Asp Trp Thr Glu Cys 
785                 790                 795                 800 


Ser Thr Ser Cys Gly Glu Gly Thr Gln Thr Arg Ser Ala Ile Cys Arg 
                805                 810                 815     


Lys Met Leu Lys Thr Gly Leu Ser Thr Val Val Asn Ser Thr Leu Cys 
            820                 825                 830         


Pro Pro Leu Pro Phe Ser Ser Ser Ile Arg Pro Cys Met Leu Ala Thr 
        835                 840                 845             


Cys Ala Arg Pro Gly Arg Pro Ser Thr Lys His Ser Pro His Ile Ala 
    850                 855                 860                 


Ala Ala Arg Lys Val Tyr Ile Gln Thr Arg Arg Gln Arg Lys Leu His 
865                 870                 875                 880 


Phe Val Val Gly Gly Phe Ala Tyr Leu Leu Pro Lys Thr Ala Val Val 
                885                 890                 895     


Leu Arg Cys Pro Ala Arg Arg Val Arg Lys Pro Leu Ile Thr Trp Glu 
            900                 905                 910         


Lys Asp Gly Gln His Leu Ile Ser Ser Thr His Val Thr Val Ala Pro 
        915                 920                 925             


Phe Gly Tyr Leu Lys Ile His Arg Leu Lys Pro Ser Asp Ala Gly Val 
    930                 935                 940                 


Tyr Thr Cys Ser Ala Gly Pro Ala Arg Glu His Phe Val Ile Lys Leu 
945                 950                 955                 960 


Ile Gly Gly Asn Arg Lys Leu Val Ala Arg Pro Leu Ser Pro Arg Ser 
                965                 970                 975     


Glu Glu Glu Val Leu Ala Gly Arg Lys Gly Gly Pro Lys Glu Ala Leu 
            980                 985                 990         


Gln Thr His Lys His Gln Asn Gly  Ile Phe Ser Asn Gly  Ser Lys Ala 
        995                 1000                 1005             


Glu Lys  Arg Gly Leu Ala Ala  Asn Pro Gly Ser Arg  Tyr Asp Asp 
    1010                 1015                 1020             


Leu Val  Ser Arg Leu Leu Glu  Gln Gly Gly Trp Pro  Gly Glu Leu 
    1025                 1030                 1035             


Leu Ala  Ser Trp Glu Ala Gln  Asp Ser Ala Glu Arg  Asn Thr Thr 
    1040                 1045                 1050             


Ser Glu  Glu Asp Pro Gly Ala  Glu Gln Val Leu Leu  His Leu Pro 
    1055                 1060                 1065             


Phe Thr  Met Val Thr Glu Gln  Arg Arg Leu Asp Asp  Ile Leu Gly 
    1070                 1075                 1080             


Asn Leu  Ser Gln Gln Pro Glu  Glu Leu Arg Asp Leu  Tyr Ser Lys 
    1085                 1090                 1095             


His Leu  Val Ala Gln Leu Ala  Gln Glu Ile Phe Arg  Ser His Leu 
    1100                 1105                 1110             


Glu His  Gln Asp Thr Leu Leu  Lys Pro Ser Glu Arg  Arg Thr Ser 
    1115                 1120                 1125             


Pro Val  Thr Leu Ser Pro His  Lys His Val Ser Gly  Phe Ser Ser 
    1130                 1135                 1140             


Ser Leu  Arg Thr Ser Ser Thr  Gly Asp Ala Gly Gly  Gly Ser Arg 
    1145                 1150                 1155             


Arg Pro  His Arg Lys Pro Thr  Ile Leu Arg Lys Ile  Ser Ala Ala 
    1160                 1165                 1170             


Gln Gln  Leu Ser Ala Ser Glu  Val Val Thr His Leu  Gly Gln Thr 
    1175                 1180                 1185             


Val Ala  Leu Ala Ser Gly Thr  Leu Ser Val Leu Leu  His Cys Glu 
    1190                 1195                 1200             


Ala Ile  Gly His Pro Arg Pro  Thr Ile Ser Trp Ala  Arg Asn Gly 
    1205                 1210                 1215             


Glu Glu  Val Gln Phe Ser Asp  Arg Ile Leu Leu Gln  Pro Asp Asp 
    1220                 1225                 1230             


Ser Leu  Gln Ile Leu Ala Pro  Val Glu Ala Asp Val  Gly Phe Tyr 
    1235                 1240                 1245             


Thr Cys  Asn Ala Thr Asn Ala  Leu Gly Tyr Asp Ser  Val Ser Ile 
    1250                 1255                 1260             


Ala Val  Thr Leu Ala Gly Lys  Pro Leu Val Lys Thr  Ser Arg Met 
    1265                 1270                 1275             


Thr Val  Ile Asn Thr Glu Lys  Pro Ala Val Thr Val  Asp Ile Gly 
    1280                 1285                 1290             


Ser Thr  Ile Lys Thr Val Gln  Gly Val Asn Val Thr  Ile Asn Cys 
    1295                 1300                 1305             


Gln Val  Ala Gly Val Pro Glu  Ala Glu Val Thr Trp  Phe Arg Asn 
    1310                 1315                 1320             


Lys Ser  Lys Leu Gly Ser Pro  His His Leu His Glu  Gly Ser Leu 
    1325                 1330                 1335             


Leu Leu  Thr Asn Val Ser Ser  Ser Asp Gln Gly Leu  Tyr Ser Cys 
    1340                 1345                 1350             


Arg Ala  Ala Asn Leu His Gly  Glu Leu Thr Glu Ser  Thr Gln Leu 
    1355                 1360                 1365             


Leu Ile  Leu Asp Pro Pro Gln  Val Pro Thr Gln Leu  Glu Asp Ile 
    1370                 1375                 1380             


Arg Ala  Leu Leu Ala Ala Thr  Gly Pro Asn Leu Pro  Ser Val Leu 
    1385                 1390                 1395             


Thr Ser  Pro Leu Gly Thr Gln  Leu Val Leu Asp Pro  Gly Asn Ser 
    1400                 1405                 1410             


Ala Leu  Leu Gly Cys Pro Ile  Lys Gly His Pro Val  Pro Asn Ile 
    1415                 1420                 1425             


Thr Trp  Phe His Gly Gly Gln  Pro Ile Val Thr Ala  Thr Gly Leu 
    1430                 1435                 1440             


Thr His  His Ile Leu Ala Ala  Gly Gln Ile Leu Gln  Val Ala Asn 
    1445                 1450                 1455             


Leu Ser  Gly Gly Ser Gln Gly  Glu Phe Ser Cys Leu  Ala Gln Asn 
    1460                 1465                 1470             


Glu Ala  Gly Val Leu Met Gln  Lys Ala Ser Leu Val  Ile Gln Asp 
    1475                 1480                 1485             


Tyr Trp  Trp Ser Val Asp Arg  Leu Ala Thr Cys Ser  Ala Ser Cys 
    1490                 1495                 1500             


Gly Asn  Arg Gly Val Gln Gln  Pro Arg Leu Arg Cys  Leu Leu Asn 
    1505                 1510                 1515             


Ser Thr  Glu Val Asn Pro Ala  His Cys Ala Gly Lys  Val Arg Pro 
    1520                 1525                 1530             


Ala Val  Gln Pro Ile Ala Cys  Asn Arg Arg Asp Cys  Pro Ser Arg 
    1535                 1540                 1545             


Trp Met  Val Thr Ser Trp Ser  Ala Cys Thr Arg Ser  Cys Gly Gly 
    1550                 1555                 1560             


Gly Val  Gln Thr Arg Arg Val  Thr Cys Gln Lys Leu  Lys Ala Ser 
    1565                 1570                 1575             


Gly Ile  Ser Thr Pro Val Ser  Asn Asp Met Cys Thr  Gln Val Ala 
    1580                 1585                 1590             


Lys Arg  Pro Val Asp Thr Gln  Ala Cys Asn Gln Gln  Leu Cys Val 
    1595                 1600                 1605             


Glu Trp  Ala Phe Ser Ser Trp  Gly Gln Cys Asn Gly  Pro Cys Ile 
    1610                 1615                 1620             


Gly Pro  His Leu Ala Val Gln  His Arg Gln Val Phe  Cys Gln Thr 
    1625                 1630                 1635             


Arg Asp  Gly Ile Thr Leu Pro  Ser Glu Gln Cys Ser  Ala Leu Pro 
    1640                 1645                 1650             


Arg Pro  Val Ser Thr Gln Asn  Cys Trp Ser Glu Ala  Cys Ser Val 
    1655                 1660                 1665             


His Trp  Arg Val Ser Leu Trp  Thr Leu Cys Thr Ala  Thr Cys Gly 
    1670                 1675                 1680             


Asn Tyr  Gly Phe Gln Ser Arg  Arg Val Glu Cys Val  His Ala Arg 
    1685                 1690                 1695             


Thr Asn  Lys Ala Val Pro Glu  His Leu Cys Ser Trp  Gly Pro Arg 
    1700                 1705                 1710             


Pro Ala  Asn Trp Gln Arg Cys  Asn Ile Thr Pro Cys  Glu Asn Met 
    1715                 1720                 1725             


Glu Cys  Arg Asp Thr Thr Arg  Tyr Cys Glu Lys Val  Lys Gln Leu 
    1730                 1735                 1740             


Lys Leu  Cys Gln Leu Ser Gln  Phe Lys Ser Arg Cys  Cys Gly Thr 
    1745                 1750                 1755             


Cys Gly  Lys Ala 
    1760         


<210>  377
<211>  439
<212>  PRT
<213>  Homo Sapiens

<400>  377

Met Glu Cys Cys Arg Arg Ala Thr Pro Gly Thr Leu Leu Leu Phe Leu 
1               5                   10                  15      


Ala Phe Leu Leu Leu Ser Ser Arg Thr Ala Arg Ser Glu Glu Asp Arg 
            20                  25                  30          


Asp Gly Leu Trp Asp Ala Trp Gly Pro Trp Ser Glu Cys Ser Arg Thr 
        35                  40                  45              


Cys Gly Gly Gly Ala Ser Tyr Ser Leu Arg Arg Cys Leu Ser Ser Lys 
    50                  55                  60                  


Ser Cys Glu Gly Arg Asn Ile Arg Tyr Arg Thr Cys Ser Asn Val Asp 
65                  70                  75                  80  


Cys Pro Pro Glu Ala Gly Asp Phe Arg Ala Gln Gln Cys Ser Ala His 
                85                  90                  95      


Asn Asp Val Lys His His Gly Gln Phe Tyr Glu Trp Leu Pro Val Ser 
            100                 105                 110         


Asn Asp Pro Asp Asn Pro Cys Ser Leu Lys Cys Gln Ala Lys Gly Thr 
        115                 120                 125             


Thr Leu Val Val Glu Leu Ala Pro Lys Val Leu Asp Gly Thr Arg Cys 
    130                 135                 140                 


Tyr Thr Glu Ser Leu Asp Met Cys Ile Ser Gly Leu Cys Gln Ile Val 
145                 150                 155                 160 


Gly Cys Asp His Gln Leu Gly Ser Thr Val Lys Glu Asp Asn Cys Gly 
                165                 170                 175     


Val Cys Asn Gly Asp Gly Ser Thr Cys Arg Leu Val Arg Gly Gln Tyr 
            180                 185                 190         


Lys Ser Gln Leu Ser Ala Thr Lys Ser Asp Asp Thr Val Val Ala Ile 
        195                 200                 205             


Pro Tyr Gly Ser Arg His Ile Arg Leu Val Leu Lys Gly Pro Asp His 
    210                 215                 220                 


Leu Tyr Leu Glu Thr Lys Thr Leu Gln Gly Thr Lys Gly Glu Asn Ser 
225                 230                 235                 240 


Leu Ser Ser Thr Gly Thr Phe Leu Val Asp Asn Ser Ser Val Asp Phe 
                245                 250                 255     


Gln Lys Phe Pro Asp Lys Glu Ile Leu Arg Met Ala Gly Pro Leu Thr 
            260                 265                 270         


Ala Asp Phe Ile Val Lys Ile Arg Asn Ser Gly Ser Ala Asp Ser Thr 
        275                 280                 285             


Val Gln Phe Ile Phe Tyr Gln Pro Ile Ile His Arg Trp Arg Glu Thr 
    290                 295                 300                 


Asp Phe Phe Pro Cys Ser Ala Thr Cys Gly Gly Gly Tyr Gln Leu Thr 
305                 310                 315                 320 


Ser Ala Glu Cys Tyr Asp Leu Arg Ser Asn Arg Val Val Ala Asp Gln 
                325                 330                 335     


Tyr Cys His Tyr Tyr Pro Glu Asn Ile Lys Pro Lys Pro Lys Leu Gln 
            340                 345                 350         


Glu Cys Asn Leu Asp Pro Cys Pro Ala Arg Trp Glu Ala Thr Pro Trp 
        355                 360                 365             


Thr Ala Cys Ser Ser Ser Cys Gly Gly Gly Ile Gln Ser Arg Ala Val 
    370                 375                 380                 


Ser Cys Val Glu Glu Asp Ile Gln Gly His Val Thr Ser Val Glu Glu 
385                 390                 395                 400 


Trp Lys Cys Met Tyr Thr Pro Lys Met Pro Ile Ala Gln Pro Cys Asn 
                405                 410                 415     


Ile Phe Asp Cys Pro Lys Trp Leu Ala Gln Glu Trp Ser Pro Val Thr 
            420                 425                 430         


Val Pro Ser Phe Phe Val His 
        435                 


<210>  378
<211>  185
<212>  PRT
<213>  Homo Sapiens

<400>  378

Met Glu Cys Cys Arg Arg Ala Thr Pro Gly Thr Leu Leu Leu Phe Leu 
1               5                   10                  15      


Ala Phe Leu Leu Leu Ser Ser Arg Thr Ala Arg Ser Glu Glu Asp Arg 
            20                  25                  30          


Asp Gly Leu Trp Asp Ala Trp Gly Pro Trp Ser Glu Cys Ser Arg Thr 
        35                  40                  45              


Cys Gly Gly Gly Ala Ser Tyr Ser Leu Arg Arg Cys Leu Ser Ser Lys 
    50                  55                  60                  


Ser Cys Glu Gly Arg Asn Ile Arg Tyr Arg Thr Cys Ser Asn Val Asp 
65                  70                  75                  80  


Cys Pro Pro Glu Ala Gly Asp Phe Arg Ala Gln Gln Cys Ser Ala His 
                85                  90                  95      


Asn Asp Val Lys His His Gly Gln Phe Tyr Glu Trp Leu Pro Val Ser 
            100                 105                 110         


Asn Asp Pro Asp Asn Pro Cys Ser Leu Lys Cys Gln Ala Lys Gly Thr 
        115                 120                 125             


Thr Leu Val Val Glu Leu Ala Pro Lys Val Leu Asp Gly Thr Arg Cys 
    130                 135                 140                 


Tyr Thr Glu Ser Leu Asp Met Cys Ile Ser Gly Leu Cys Gln Val Ser 
145                 150                 155                 160 


Ala Asp Leu Phe Ser Phe Asn Leu Ser Arg Gly Phe Gln Cys Leu Cys 
                165                 170                 175     


Val Asn Gly Leu His Ser Leu Thr Leu 
            180                 185 


<210>  379
<211>  258
<212>  PRT
<213>  Homo Sapiens

<400>  379

Met Ser Gly Val Phe Cys Phe Phe Phe Phe Phe Leu Gly Val Pro Glu 
1               5                   10                  15      


Ala Glu Val Thr Trp Phe Arg Asn Lys Ser Lys Leu Gly Ser Pro His 
            20                  25                  30          


His Leu His Glu Gly Ser Leu Leu Leu Thr Asn Val Ser Ser Ser Asp 
        35                  40                  45              


Gln Gly Leu Tyr Ser Cys Arg Ala Ala Asn Leu His Gly Glu Leu Thr 
    50                  55                  60                  


Glu Ser Thr Gln Leu Leu Ile Leu Asp Pro Pro Gln Val Pro Thr Gln 
65                  70                  75                  80  


Leu Glu Asp Ile Arg Ala Leu Leu Ala Ala Thr Gly Pro Asn Leu Pro 
                85                  90                  95      


Ser Val Leu Thr Ser Pro Leu Gly Thr Gln Leu Val Leu Asp Pro Gly 
            100                 105                 110         


Asn Ser Ala Leu Leu Gly Cys Pro Ile Lys Gly His Pro Val Pro Asn 
        115                 120                 125             


Ile Thr Trp Phe His Gly Gly Gln Pro Ile Val Thr Ala Thr Gly Leu 
    130                 135                 140                 


Thr His His Ile Leu Ala Ala Gly Gln Ile Leu Gln Val Ala Asn Leu 
145                 150                 155                 160 


Ser Gly Gly Ser Gln Gly Glu Phe Ser Cys Leu Ala Gln Asn Glu Ala 
                165                 170                 175     


Gly Val Leu Met Gln Lys Ala Ser Leu Val Ile Gln Asp Tyr Trp Trp 
            180                 185                 190         


Ser Val Asp Arg Leu Ala Thr Cys Ser Ala Ser Cys Gly Asn Arg Gly 
        195                 200                 205             


Val Gln Gln Pro Arg Leu Arg Cys Leu Leu Asn Ser Thr Glu Val Asn 
    210                 215                 220                 


Pro Ala His Cys Ala Gly Lys Val Arg Pro Ala Val Gln Pro Ile Ala 
225                 230                 235                 240 


Cys Asn Arg Arg Asp Cys Pro Ser Arg Ala Met Gly Leu Ala Ser Gly 
                245                 250                 255     


Leu Thr 
        


<210>  380
<211>  463
<212>  PRT
<213>  Homo Sapiens

<400>  380

Met Ser Gly Val Phe Cys Phe Phe Phe Phe Phe Leu Gly Val Pro Glu 
1               5                   10                  15      


Ala Glu Val Thr Trp Phe Arg Asn Lys Ser Lys Leu Gly Ser Pro His 
            20                  25                  30          


His Leu His Glu Gly Ser Leu Leu Leu Thr Asn Val Ser Ser Ser Asp 
        35                  40                  45              


Gln Gly Leu Tyr Ser Cys Arg Ala Ala Asn Leu His Gly Glu Leu Thr 
    50                  55                  60                  


Glu Ser Thr Gln Leu Leu Ile Leu Asp Pro Pro Gln Val Pro Thr Gln 
65                  70                  75                  80  


Leu Glu Asp Ile Arg Ala Leu Leu Ala Ala Thr Gly Pro Asn Leu Pro 
                85                  90                  95      


Ser Val Leu Thr Ser Pro Leu Gly Thr Gln Leu Val Leu Asp Pro Gly 
            100                 105                 110         


Asn Ser Ala Leu Leu Gly Cys Pro Ile Lys Gly His Pro Val Pro Asn 
        115                 120                 125             


Ile Thr Trp Phe His Gly Gly Gln Pro Ile Val Thr Ala Thr Gly Leu 
    130                 135                 140                 


Thr His His Ile Leu Ala Ala Gly Gln Ile Leu Gln Val Ala Asn Leu 
145                 150                 155                 160 


Ser Gly Gly Ser Gln Gly Glu Phe Ser Cys Leu Ala Gln Asn Glu Ala 
                165                 170                 175     


Gly Val Leu Met Gln Lys Ala Ser Leu Val Ile Gln Asp Tyr Trp Trp 
            180                 185                 190         


Ser Val Asp Arg Leu Ala Thr Cys Ser Ala Ser Cys Gly Asn Arg Gly 
        195                 200                 205             


Val Gln Gln Pro Arg Leu Arg Cys Leu Leu Asn Ser Thr Glu Val Asn 
    210                 215                 220                 


Pro Ala His Cys Ala Gly Lys Val Arg Pro Ala Val Gln Pro Ile Ala 
225                 230                 235                 240 


Cys Asn Arg Arg Asp Cys Pro Ser Arg Trp Met Val Thr Ser Trp Ser 
                245                 250                 255     


Ala Cys Thr Arg Ser Cys Gly Gly Gly Val Gln Thr Arg Arg Val Thr 
            260                 265                 270         


Cys Gln Lys Leu Lys Ala Ser Gly Ile Ser Thr Pro Val Ser Asn Asp 
        275                 280                 285             


Met Cys Thr Gln Val Ala Lys Arg Pro Val Asp Thr Gln Ala Cys Asn 
    290                 295                 300                 


Gln Gln Leu Cys Val Glu Trp Ala Phe Ser Ser Trp Gly Gln Cys Asn 
305                 310                 315                 320 


Gly Pro Cys Ile Gly Pro His Leu Ala Val Gln His Arg Gln Val Phe 
                325                 330                 335     


Cys Gln Thr Arg Asp Gly Ile Thr Leu Pro Ser Glu Gln Cys Ser Ala 
            340                 345                 350         


Leu Pro Arg Pro Val Ser Thr Gln Asn Cys Trp Ser Glu Ala Cys Ser 
        355                 360                 365             


Val His Trp Arg Val Ser Leu Trp Thr Leu Cys Thr Ala Thr Cys Gly 
    370                 375                 380                 


Asn Tyr Gly Phe Gln Ser Arg Arg Val Glu Cys Val His Ala Arg Thr 
385                 390                 395                 400 


Asn Lys Ala Val Pro Glu His Leu Cys Ser Trp Gly Pro Arg Pro Ala 
                405                 410                 415     


Asn Trp Gln Arg Cys Asn Ile Thr Pro Cys Glu Asn Met Glu Cys Arg 
            420                 425                 430         


Asp Thr Thr Arg Tyr Cys Glu Lys Val Lys Gln Leu Lys Leu Cys Gln 
        435                 440                 445             


Leu Ser Gln Phe Lys Ser Arg Cys Cys Gly Thr Cys Gly Lys Ala 
    450                 455                 460             


<210>  381
<211>  275
<212>  PRT
<213>  Homo Sapiens

<400>  381

Met Ser Gly Val Phe Cys Phe Phe Phe Phe Phe Leu Gly Val Pro Glu 
1               5                   10                  15      


Ala Glu Val Thr Trp Phe Arg Asn Lys Ser Lys Leu Gly Ser Pro His 
            20                  25                  30          


His Leu His Glu Gly Ser Leu Leu Leu Thr Asn Val Ser Ser Ser Asp 
        35                  40                  45              


Gln Gly Leu Tyr Ser Cys Arg Ala Ala Asn Leu His Gly Glu Leu Thr 
    50                  55                  60                  


Glu Ser Thr Gln Leu Leu Ile Leu Asp Pro Pro Gln Val Pro Thr Gln 
65                  70                  75                  80  


Leu Glu Asp Ile Arg Ala Leu Leu Ala Ala Thr Gly Pro Asn Leu Pro 
                85                  90                  95      


Ser Val Leu Thr Ser Pro Leu Gly Thr Gln Leu Val Leu Asp Pro Gly 
            100                 105                 110         


Asn Ser Ala Leu Leu Gly Cys Pro Ile Lys Gly His Pro Val Pro Asn 
        115                 120                 125             


Ile Thr Trp Phe His Gly Gly Gln Pro Ile Val Thr Ala Thr Gly Leu 
    130                 135                 140                 


Thr His His Ile Leu Ala Ala Gly Gln Ile Leu Gln Val Ala Asn Leu 
145                 150                 155                 160 


Ser Gly Gly Ser Gln Gly Glu Phe Ser Cys Leu Ala Gln Asn Glu Ala 
                165                 170                 175     


Gly Val Leu Met Gln Lys Ala Ser Leu Val Ile Gln Val Gln Trp Ala 
            180                 185                 190         


Leu His Arg Ala Ser Pro Ser Cys Ala Thr Gln Thr Ser Leu Leu Pro 
        195                 200                 205             


Asp Thr Gly Trp His His Leu Thr Ile Arg Ala Val Gln Cys Ser Ser 
    210                 215                 220                 


Glu Ala Cys Glu His Pro Glu Leu Leu Val Arg Gly Leu Gln Cys Thr 
225                 230                 235                 240 


Leu Glu Ser Gln Pro Val Asp Pro Val His Ser Tyr Leu Trp Gln Leu 
                245                 250                 255     


Arg Leu Pro Val Pro Ala Cys Gly Val Cys Ala Cys Pro His Gln Gln 
            260                 265                 270         


Gly Ser Ala 
        275 


<210>  382
<211>  150
<212>  PRT
<213>  Homo Sapiens

<400>  382

Thr Ser Pro Leu Gly Thr Gln Leu Val Leu Asp Pro Gly Asn Ser Ala 
1               5                   10                  15      


Leu Leu Gly Cys Pro Ile Lys Gly His Pro Val Pro Asn Ile Thr Trp 
            20                  25                  30          


Phe His Gly Gly Gln Pro Ile Val Thr Ala Thr Gly Leu Thr His His 
        35                  40                  45              


Ile Leu Ala Ala Gly Gln Ile Leu Gln Val Ala Asn Leu Ser Gly Gly 
    50                  55                  60                  


Ser Gln Gly Glu Phe Ser Cys Leu Ala Gln Asn Glu Ala Gly Val Leu 
65                  70                  75                  80  


Met Gln Lys Ala Ser Leu Val Ile Gln Asp Tyr Trp Trp Ser Val Asp 
                85                  90                  95      


Arg Leu Ala Thr Cys Ser Ala Ser Cys Gly Asn Arg Gly Val Gln Gln 
            100                 105                 110         


Pro Arg Leu Arg Cys Leu Leu Asn Ser Thr Glu Val Asn Pro Ala His 
        115                 120                 125             


Cys Ala Gly Lys Val Arg Pro Ala Val Gln Pro Ile Ala Cys Asn Arg 
    130                 135                 140                 


Arg Asp Cys Pro Ser Arg 
145                 150 


<210>  383
<211>  951
<212>  PRT
<213>  Homo Sapiens

<400>  383

Met Asp Gly Arg Trp Gln Cys Ser Cys Trp Ala Trp Phe Leu Leu Val 
1               5                   10                  15      


Leu Ala Val Val Ala Gly Asp Thr Val Ser Thr Gly Ser Thr Asp Asn 
            20                  25                  30          


Ser Pro Thr Ser Asn Ser Leu Glu Gly Gly Thr Asp Ala Thr Ala Phe 
        35                  40                  45              


Trp Trp Gly Glu Trp Thr Lys Trp Thr Ala Cys Ser Arg Ser Cys Gly 
    50                  55                  60                  


Gly Gly Val Thr Ser Gln Glu Arg His Cys Leu Gln Gln Arg Arg Lys 
65                  70                  75                  80  


Ser Val Pro Gly Pro Gly Asn Arg Thr Cys Thr Gly Thr Ser Lys Arg 
                85                  90                  95      


Tyr Gln Leu Cys Arg Val Gln Glu Cys Pro Pro Asp Gly Arg Ser Phe 
            100                 105                 110         


Arg Glu Glu Gln Cys Val Ser Phe Asn Ser His Val Tyr Asn Gly Arg 
        115                 120                 125             


Thr His Gln Trp Lys Pro Leu Tyr Pro Asp Asp Tyr Val His Ile Ser 
    130                 135                 140                 


Ser Lys Pro Cys Asp Leu His Cys Thr Thr Val Asp Gly Gln Arg Gln 
145                 150                 155                 160 


Leu Met Val Pro Ala Arg Asp Gly Thr Ser Cys Lys Leu Thr Asp Leu 
                165                 170                 175     


Arg Gly Val Cys Val Ser Gly Lys Cys Glu Pro Ile Gly Cys Asp Gly 
            180                 185                 190         


Val Leu Phe Ser Thr His Thr Leu Asp Lys Cys Gly Ile Cys Gln Gly 
        195                 200                 205             


Asp Gly Ser Ser Cys Thr His Val Thr Gly Asn Tyr Arg Lys Gly Asn 
    210                 215                 220                 


Ala His Leu Gly Tyr Ser Leu Val Thr His Ile Pro Ala Gly Ala Arg 
225                 230                 235                 240 


Asp Ile Gln Ile Val Glu Arg Lys Lys Ser Ala Asp Val Leu Ala Leu 
                245                 250                 255     


Ala Asp Glu Ala Gly Tyr Tyr Phe Phe Asn Gly Asn Tyr Lys Val Asp 
            260                 265                 270         


Ser Pro Lys Asn Phe Asn Ile Ala Gly Thr Val Val Lys Tyr Arg Arg 
        275                 280                 285             


Pro Met Asp Val Tyr Glu Thr Gly Ile Glu Tyr Ile Val Ala Gln Gly 
    290                 295                 300                 


Pro Thr Asn Gln Gly Leu Asn Val Met Val Trp Asn Gln Asn Gly Lys 
305                 310                 315                 320 


Ser Pro Ser Ile Thr Phe Glu Tyr Thr Leu Leu Gln Pro Pro His Glu 
                325                 330                 335     


Ser Arg Pro Gln Pro Ile Tyr Tyr Gly Phe Ser Glu Ser Ala Glu Ser 
            340                 345                 350         


Gln Gly Leu Asp Gly Ala Gly Leu Met Gly Phe Val Pro His Asn Gly 
        355                 360                 365             


Ser Leu Tyr Gly Gln Ala Ser Ser Glu Arg Leu Gly Leu Asp Asn Arg 
    370                 375                 380                 


Leu Phe Gly His Pro Gly Leu Asp Met Glu Leu Gly Pro Ser Gln Gly 
385                 390                 395                 400 


Gln Glu Thr Asn Glu Val Cys Glu Gln Ala Gly Gly Gly Ala Cys Glu 
                405                 410                 415     


Gly Pro Pro Arg Gly Lys Gly Phe Arg Asp Arg Asn Val Thr Gly Thr 
            420                 425                 430         


Pro Leu Thr Gly Asp Lys Asp Asp Glu Glu Val Asp Thr His Phe Ala 
        435                 440                 445             


Ser Gln Glu Phe Phe Ser Ala Asn Ala Ile Ser Asp Gln Leu Leu Gly 
    450                 455                 460                 


Ala Gly Ser Asp Leu Lys Asp Phe Thr Leu Asn Glu Thr Val Asn Ser 
465                 470                 475                 480 


Ile Phe Ala Gln Gly Ala Pro Arg Ser Ser Leu Ala Glu Ser Phe Phe 
                485                 490                 495     


Val Asp Tyr Glu Glu Asn Glu Gly Ala Gly Pro Tyr Leu Leu Asn Gly 
            500                 505                 510         


Ser Tyr Leu Glu Leu Ser Ser Asp Arg Val Ala Asn Ser Ser Ser Glu 
        515                 520                 525             


Ala Pro Phe Pro Asn Val Ser Thr Ser Leu Leu Thr Ser Ala Gly Asn 
    530                 535                 540                 


Arg Thr His Lys Ala Arg Thr Arg Pro Lys Ala Arg Lys Gln Gly Val 
545                 550                 555                 560 


Ser Pro Ala Asp Met Tyr Arg Trp Lys Leu Ser Ser His Glu Pro Cys 
                565                 570                 575     


Ser Ala Thr Cys Thr Thr Gly Val Met Ser Ala Tyr Ala Met Cys Val 
            580                 585                 590         


Arg Tyr Asp Gly Val Glu Val Asp Asp Ser Tyr Cys Asp Ala Leu Thr 
        595                 600                 605             


Arg Pro Glu Pro Val His Glu Phe Cys Ala Gly Arg Glu Cys Gln Pro 
    610                 615                 620                 


Arg Trp Glu Thr Ser Ser Trp Ser Glu Cys Ser Arg Thr Cys Gly Glu 
625                 630                 635                 640 


Gly Tyr Gln Phe Arg Val Val Arg Cys Trp Lys Met Leu Ser Pro Gly 
                645                 650                 655     


Phe Asp Ser Ser Val Tyr Ser Asp Leu Cys Glu Ala Ala Glu Ala Val 
            660                 665                 670         


Arg Pro Glu Glu Arg Lys Thr Cys Arg Asn Pro Ala Cys Gly Pro Gln 
        675                 680                 685             


Trp Glu Met Ser Glu Trp Ser Glu Cys Thr Ala Lys Cys Gly Glu Arg 
    690                 695                 700                 


Ser Val Val Thr Arg Asp Ile Arg Cys Ser Glu Asp Glu Lys Leu Cys 
705                 710                 715                 720 


Asp Pro Asn Thr Arg Pro Val Gly Glu Lys Asn Cys Thr Gly Pro Pro 
                725                 730                 735     


Cys Asp Arg Gln Trp Thr Val Ser Asp Trp Gly Pro Cys Ser Gly Ser 
            740                 745                 750         


Cys Gly Gln Gly Arg Thr Ile Arg His Val Tyr Cys Lys Thr Ser Asp 
        755                 760                 765             


Gly Arg Val Val Pro Glu Ser Gln Cys Gln Met Glu Thr Lys Pro Leu 
    770                 775                 780                 


Ala Ile His Pro Cys Gly Asp Lys Asn Cys Pro Ala His Trp Leu Ala 
785                 790                 795                 800 


Gln Asp Trp Glu Arg Cys Asn Thr Thr Cys Gly Arg Gly Val Lys Lys 
                805                 810                 815     


Arg Leu Val Leu Cys Met Glu Leu Ala Asn Gly Lys Pro Gln Thr Arg 
            820                 825                 830         


Ser Gly Pro Glu Cys Gly Leu Ala Lys Lys Pro Pro Glu Glu Ser Thr 
        835                 840                 845             


Cys Phe Glu Arg Pro Cys Phe Lys Trp Tyr Thr Ser Pro Trp Ser Glu 
    850                 855                 860                 


Cys Thr Lys Thr Cys Gly Val Gly Val Arg Met Arg Asp Val Lys Cys 
865                 870                 875                 880 


Tyr Gln Gly Thr Asp Ile Val Arg Gly Cys Asp Pro Leu Val Lys Pro 
                885                 890                 895     


Val Gly Arg Gln Ala Cys Asp Leu Gln Pro Cys Pro Thr Glu Pro Pro 
            900                 905                 910         


Asp Asp Ser Cys Gln Asp Gln Pro Gly Thr Asn Cys Ala Leu Ala Ile 
        915                 920                 925             


Lys Val Asn Leu Cys Gly His Trp Tyr Tyr Ser Lys Ala Cys Cys Arg 
    930                 935                 940                 


Ser Cys Arg Pro Pro His Ser 
945                 950     


<210>  384
<211>  951
<212>  PRT
<213>  Homo Sapiens

<400>  384

Met Asp Gly Arg Trp Gln Cys Ser Cys Trp Ala Trp Phe Leu Leu Val 
1               5                   10                  15      


Leu Ala Val Val Ala Gly Asp Thr Val Ser Thr Gly Ser Thr Asp Asn 
            20                  25                  30          


Ser Pro Thr Ser Asn Ser Leu Glu Gly Gly Thr Asp Ala Thr Ala Phe 
        35                  40                  45              


Trp Trp Gly Glu Trp Thr Lys Trp Thr Ala Cys Ser Arg Ser Cys Gly 
    50                  55                  60                  


Gly Gly Val Thr Ser Gln Glu Arg His Cys Leu Gln Gln Arg Arg Lys 
65                  70                  75                  80  


Ser Val Pro Gly Pro Gly Asn Arg Thr Cys Thr Gly Thr Ser Lys Arg 
                85                  90                  95      


Tyr Gln Leu Cys Arg Val Gln Glu Cys Pro Pro Asp Gly Arg Ser Phe 
            100                 105                 110         


Arg Glu Glu Gln Cys Val Ser Phe Asn Ser His Val Tyr Asn Gly Arg 
        115                 120                 125             


Thr His Gln Trp Lys Pro Leu Tyr Pro Asp Asp Tyr Val His Ile Ser 
    130                 135                 140                 


Ser Lys Pro Cys Asp Leu His Cys Thr Thr Val Asp Gly Gln Arg Gln 
145                 150                 155                 160 


Leu Met Val Pro Ala Arg Asp Gly Thr Ser Cys Lys Leu Thr Asp Leu 
                165                 170                 175     


Arg Gly Val Cys Val Ser Gly Lys Cys Glu Pro Ile Gly Cys Asp Gly 
            180                 185                 190         


Val Leu Phe Ser Thr His Thr Leu Asp Lys Cys Gly Ile Cys Gln Gly 
        195                 200                 205             


Asp Gly Ser Ser Cys Thr His Val Thr Gly Asn Tyr Arg Lys Gly Asn 
    210                 215                 220                 


Ala His Leu Gly Tyr Ser Leu Val Thr His Ile Pro Ala Gly Ala Arg 
225                 230                 235                 240 


Asp Ile Gln Ile Val Glu Arg Lys Lys Ser Ala Asp Val Leu Ala Leu 
                245                 250                 255     


Ala Asp Glu Ala Gly Tyr Tyr Phe Phe Asn Gly Asn Tyr Lys Val Asp 
            260                 265                 270         


Ser Pro Lys Asn Phe Asn Ile Ala Gly Thr Val Val Lys Tyr Arg Arg 
        275                 280                 285             


Pro Met Asp Val Tyr Glu Thr Gly Ile Glu Tyr Ile Val Ala Gln Gly 
    290                 295                 300                 


Pro Thr Asn Gln Gly Leu Asn Val Met Val Trp Asn Gln Asn Gly Lys 
305                 310                 315                 320 


Ser Pro Ser Ile Thr Phe Glu Tyr Thr Leu Leu Gln Pro Pro His Glu 
                325                 330                 335     


Ser Arg Pro Gln Pro Ile Tyr Tyr Gly Phe Ser Glu Ser Ala Glu Ser 
            340                 345                 350         


Gln Gly Leu Asp Gly Ala Gly Leu Met Gly Phe Val Pro His Asn Gly 
        355                 360                 365             


Ser Leu Tyr Gly Gln Ala Ser Ser Glu Arg Leu Gly Leu Asp Asn Arg 
    370                 375                 380                 


Leu Phe Gly His Pro Gly Leu Asp Met Glu Leu Gly Pro Ser Gln Gly 
385                 390                 395                 400 


Gln Glu Thr Asn Glu Val Cys Glu Gln Ala Gly Gly Gly Ala Cys Glu 
                405                 410                 415     


Gly Pro Pro Arg Gly Lys Gly Phe Arg Asp Arg Asn Val Thr Gly Thr 
            420                 425                 430         


Pro Leu Thr Gly Asp Lys Asp Asp Glu Glu Val Asp Thr His Phe Ala 
        435                 440                 445             


Ser Gln Glu Phe Phe Ser Ala Asn Ala Ile Ser Asp Gln Leu Leu Gly 
    450                 455                 460                 


Ala Gly Ser Asp Leu Lys Asp Phe Thr Leu Asn Glu Thr Val Asn Ser 
465                 470                 475                 480 


Ile Phe Ala Gln Gly Ala Pro Arg Ser Ser Leu Ala Glu Ser Phe Phe 
                485                 490                 495     


Val Asp Tyr Glu Glu Asn Glu Gly Ala Gly Pro Tyr Leu Leu Asn Gly 
            500                 505                 510         


Ser Tyr Leu Glu Leu Ser Ser Asp Arg Val Ala Asn Ser Ser Ser Glu 
        515                 520                 525             


Ala Pro Phe Pro Asn Val Ser Thr Ser Leu Leu Thr Ser Ala Gly Asn 
    530                 535                 540                 


Arg Thr His Lys Ala Arg Thr Arg Pro Lys Ala Arg Lys Gln Gly Val 
545                 550                 555                 560 


Ser Pro Ala Asp Met Tyr Arg Trp Lys Leu Ser Ser His Glu Pro Cys 
                565                 570                 575     


Ser Ala Thr Cys Thr Thr Gly Val Met Ser Ala Tyr Ala Met Cys Val 
            580                 585                 590         


Arg Tyr Asp Gly Val Glu Val Asp Asp Ser Tyr Cys Asp Ala Leu Thr 
        595                 600                 605             


Arg Pro Glu Pro Val His Glu Phe Cys Ala Gly Arg Glu Cys Gln Pro 
    610                 615                 620                 


Arg Trp Glu Thr Ser Ser Trp Ser Glu Cys Ser Arg Thr Cys Gly Glu 
625                 630                 635                 640 


Gly Tyr Gln Phe Arg Val Val Arg Cys Trp Lys Met Leu Ser Pro Gly 
                645                 650                 655     


Phe Asp Ser Ser Val Tyr Ser Asp Leu Cys Glu Ala Ala Glu Ala Val 
            660                 665                 670         


Arg Pro Glu Glu Arg Lys Thr Cys Arg Asn Pro Ala Cys Gly Pro Gln 
        675                 680                 685             


Trp Glu Met Ser Glu Trp Ser Glu Cys Thr Ala Lys Cys Gly Glu Arg 
    690                 695                 700                 


Ser Val Val Thr Arg Asp Ile Arg Cys Ser Glu Asp Glu Lys Leu Cys 
705                 710                 715                 720 


Asp Pro Asn Thr Arg Pro Val Gly Glu Lys Asn Cys Thr Gly Pro Pro 
                725                 730                 735     


Cys Asp Arg Gln Trp Thr Val Ser Asp Trp Gly Pro Cys Ser Gly Ser 
            740                 745                 750         


Cys Gly Gln Gly Arg Thr Ile Arg His Val Tyr Cys Lys Thr Ser Asp 
        755                 760                 765             


Gly Arg Val Val Pro Glu Ser Gln Cys Gln Met Glu Thr Lys Pro Leu 
    770                 775                 780                 


Ala Ile His Pro Cys Gly Asp Lys Asn Cys Pro Ala His Trp Leu Ala 
785                 790                 795                 800 


Gln Asp Trp Glu Arg Cys Asn Thr Thr Cys Gly Arg Gly Val Lys Lys 
                805                 810                 815     


Arg Leu Val Leu Cys Met Glu Leu Ala Asn Gly Lys Pro Gln Thr Arg 
            820                 825                 830         


Ser Gly Pro Glu Cys Gly Leu Ala Lys Lys Pro Pro Glu Glu Ser Thr 
        835                 840                 845             


Cys Phe Glu Arg Pro Cys Phe Lys Trp Tyr Thr Ser Pro Trp Ser Glu 
    850                 855                 860                 


Cys Thr Lys Thr Cys Gly Val Gly Val Arg Met Arg Asp Val Lys Cys 
865                 870                 875                 880 


Tyr Gln Gly Thr Asp Ile Val Arg Gly Cys Asp Pro Leu Val Lys Pro 
                885                 890                 895     


Val Gly Arg Gln Ala Cys Asp Leu Gln Pro Cys Pro Thr Glu Pro Pro 
            900                 905                 910         


Asp Asp Ser Cys Gln Asp Gln Pro Gly Thr Asn Cys Ala Leu Ala Ile 
        915                 920                 925             


Lys Val Asn Leu Cys Gly His Trp Tyr Tyr Ser Lys Ala Cys Cys Arg 
    930                 935                 940                 


Ser Cys Arg Pro Pro His Ser 
945                 950     


<210>  385
<211>  1060
<212>  PRT
<213>  Homo Sapiens

<400>  385

Met Leu Phe Glu Val Gly Glu Gly Gly Gly Ala Gly Glu Glu Gly Lys 
1               5                   10                  15      


Gly Arg Gly Arg Pro Gly Arg Ser Leu Cys Thr His Ala Ala Pro Ala 
            20                  25                  30          


Arg Thr Ala His Leu Ala Pro Ser Ala Leu Arg Ser Ala Arg Pro Phe 
        35                  40                  45              


Leu Trp Glu Asp Asn Leu Leu Thr Arg Ser Gln Gly Leu Pro Asp Asn 
    50                  55                  60                  


His Asp Gln Leu Val Pro Asp Asn Leu Glu Ala Trp Ala Leu Ala Gly 
65                  70                  75                  80  


Pro Arg Gly Leu Phe Pro Lys Arg Thr Leu Val Ile Trp Lys Arg Ile 
                85                  90                  95      


Gly Ala Gly Leu Val Val Thr Val Ala Leu Leu Pro Arg Met Asp Gly 
            100                 105                 110         


Arg Trp Gln Cys Ser Cys Trp Ala Trp Phe Leu Leu Val Leu Ala Val 
        115                 120                 125             


Val Ala Gly Asp Thr Val Ser Thr Gly Ser Thr Asp Asn Ser Pro Thr 
    130                 135                 140                 


Ser Asn Ser Leu Glu Gly Gly Thr Asp Ala Thr Ala Phe Trp Trp Gly 
145                 150                 155                 160 


Glu Trp Thr Lys Trp Thr Ala Cys Ser Arg Ser Cys Gly Gly Gly Val 
                165                 170                 175     


Thr Ser Gln Glu Arg His Cys Leu Gln Gln Arg Arg Lys Ser Val Pro 
            180                 185                 190         


Gly Pro Gly Asn Arg Thr Cys Thr Gly Thr Ser Lys Arg Tyr Gln Leu 
        195                 200                 205             


Cys Arg Val Gln Glu Cys Pro Pro Asp Gly Arg Ser Phe Arg Glu Glu 
    210                 215                 220                 


Gln Cys Val Ser Phe Asn Ser His Val Tyr Asn Gly Arg Thr His Gln 
225                 230                 235                 240 


Trp Lys Pro Leu Tyr Pro Asp Asp Tyr Val His Ile Ser Ser Lys Pro 
                245                 250                 255     


Cys Asp Leu His Cys Thr Thr Val Asp Gly Gln Arg Gln Leu Met Val 
            260                 265                 270         


Pro Ala Arg Asp Gly Thr Ser Cys Lys Leu Thr Asp Leu Arg Gly Val 
        275                 280                 285             


Cys Val Ser Gly Lys Cys Glu Pro Ile Gly Cys Asp Gly Val Leu Phe 
    290                 295                 300                 


Ser Thr His Thr Leu Asp Lys Cys Gly Ile Cys Gln Gly Asp Gly Ser 
305                 310                 315                 320 


Ser Cys Thr His Val Thr Gly Asn Tyr Arg Lys Gly Asn Ala His Leu 
                325                 330                 335     


Gly Tyr Ser Leu Val Thr His Ile Pro Ala Gly Ala Arg Asp Ile Gln 
            340                 345                 350         


Ile Val Glu Arg Lys Lys Ser Ala Asp Val Leu Ala Leu Ala Asp Glu 
        355                 360                 365             


Ala Gly Tyr Tyr Phe Phe Asn Gly Asn Tyr Lys Val Asp Ser Pro Lys 
    370                 375                 380                 


Asn Phe Asn Ile Ala Gly Thr Val Val Lys Tyr Arg Arg Pro Met Asp 
385                 390                 395                 400 


Val Tyr Glu Thr Gly Ile Glu Tyr Ile Val Ala Gln Gly Pro Thr Asn 
                405                 410                 415     


Gln Gly Leu Asn Val Met Val Trp Asn Gln Asn Gly Lys Ser Pro Ser 
            420                 425                 430         


Ile Thr Phe Glu Tyr Thr Leu Leu Gln Pro Pro His Glu Ser Arg Pro 
        435                 440                 445             


Gln Pro Ile Tyr Tyr Gly Phe Ser Glu Ser Ala Glu Ser Gln Gly Leu 
    450                 455                 460                 


Asp Gly Ala Gly Leu Met Gly Phe Val Pro His Asn Gly Ser Leu Tyr 
465                 470                 475                 480 


Gly Gln Ala Ser Ser Glu Arg Leu Gly Leu Asp Asn Arg Leu Phe Gly 
                485                 490                 495     


His Pro Gly Leu Asp Met Glu Leu Gly Pro Ser Gln Gly Gln Glu Thr 
            500                 505                 510         


Asn Glu Val Cys Glu Gln Ala Gly Gly Gly Ala Cys Glu Gly Pro Pro 
        515                 520                 525             


Arg Gly Lys Gly Phe Arg Asp Arg Asn Val Thr Gly Thr Pro Leu Thr 
    530                 535                 540                 


Gly Asp Lys Asp Asp Glu Glu Val Asp Thr His Phe Ala Ser Gln Glu 
545                 550                 555                 560 


Phe Phe Ser Ala Asn Ala Ile Ser Asp Gln Leu Leu Gly Ala Gly Ser 
                565                 570                 575     


Asp Leu Lys Asp Phe Thr Leu Asn Glu Thr Val Asn Ser Ile Phe Ala 
            580                 585                 590         


Gln Gly Ala Pro Arg Ser Ser Leu Ala Glu Ser Phe Phe Val Asp Tyr 
        595                 600                 605             


Glu Glu Asn Glu Gly Ala Gly Pro Tyr Leu Leu Asn Gly Ser Tyr Leu 
    610                 615                 620                 


Glu Leu Ser Ser Asp Arg Val Ala Asn Ser Ser Ser Glu Ala Pro Phe 
625                 630                 635                 640 


Pro Asn Val Ser Thr Ser Leu Leu Thr Ser Ala Gly Asn Arg Thr His 
                645                 650                 655     


Lys Ala Arg Thr Arg Pro Lys Ala Arg Lys Gln Gly Val Ser Pro Ala 
            660                 665                 670         


Asp Met Tyr Arg Trp Lys Leu Ser Ser His Glu Pro Cys Ser Ala Thr 
        675                 680                 685             


Cys Thr Thr Gly Val Met Ser Ala Tyr Ala Met Cys Val Arg Tyr Asp 
    690                 695                 700                 


Gly Val Glu Val Asp Asp Ser Tyr Cys Asp Ala Leu Thr Arg Pro Glu 
705                 710                 715                 720 


Pro Val His Glu Phe Cys Ala Gly Arg Glu Cys Gln Pro Arg Trp Glu 
                725                 730                 735     


Thr Ser Ser Trp Ser Glu Cys Ser Arg Thr Cys Gly Glu Gly Tyr Gln 
            740                 745                 750         


Phe Arg Val Val Arg Cys Trp Lys Met Leu Ser Pro Gly Phe Asp Ser 
        755                 760                 765             


Ser Val Tyr Ser Asp Leu Cys Glu Ala Ala Glu Ala Val Arg Pro Glu 
    770                 775                 780                 


Glu Arg Lys Thr Cys Arg Asn Pro Ala Cys Gly Pro Gln Trp Glu Met 
785                 790                 795                 800 


Ser Glu Trp Ser Glu Cys Thr Ala Lys Cys Gly Glu Arg Ser Val Val 
                805                 810                 815     


Thr Arg Asp Ile Arg Cys Ser Glu Asp Glu Lys Leu Cys Asp Pro Asn 
            820                 825                 830         


Thr Arg Pro Val Gly Glu Lys Asn Cys Thr Gly Pro Pro Cys Asp Arg 
        835                 840                 845             


Gln Trp Thr Val Ser Asp Trp Gly Pro Cys Ser Gly Ser Cys Gly Gln 
    850                 855                 860                 


Gly Arg Thr Ile Arg His Val Tyr Cys Lys Thr Ser Asp Gly Arg Val 
865                 870                 875                 880 


Val Pro Glu Ser Gln Cys Gln Met Glu Thr Lys Pro Leu Ala Ile His 
                885                 890                 895     


Pro Cys Gly Asp Lys Asn Cys Pro Ala His Trp Leu Ala Gln Asp Trp 
            900                 905                 910         


Glu Arg Cys Asn Thr Thr Cys Gly Arg Gly Val Lys Lys Arg Leu Val 
        915                 920                 925             


Leu Cys Met Glu Leu Ala Asn Gly Lys Pro Gln Thr Arg Ser Gly Pro 
    930                 935                 940                 


Glu Cys Gly Leu Ala Lys Lys Pro Pro Glu Glu Ser Thr Cys Phe Glu 
945                 950                 955                 960 


Arg Pro Cys Phe Lys Trp Tyr Thr Ser Pro Trp Ser Glu Cys Thr Lys 
                965                 970                 975     


Thr Cys Gly Val Gly Val Arg Met Arg Asp Val Lys Cys Tyr Gln Gly 
            980                 985                 990         


Thr Asp Ile Val Arg Gly Cys Asp  Pro Leu Val Lys Pro  Val Gly Arg 
        995                 1000                 1005             


Gln Ala  Cys Asp Leu Gln Pro  Cys Pro Thr Glu Pro  Pro Asp Asp 
    1010                 1015                 1020             


Ser Cys  Gln Asp Gln Pro Gly  Thr Asn Cys Ala Leu  Ala Ile Lys 
    1025                 1030                 1035             


Val Asn  Leu Cys Gly His Trp  Tyr Tyr Ser Lys Ala  Cys Cys Arg 
    1040                 1045                 1050             


Ser Cys  Arg Pro Pro His Ser  
    1055                 1060 


<210>  386
<211>  1691
<212>  PRT
<213>  Homo Sapiens

<400>  386

Met Ala Ser Trp Thr Ser Pro Trp Trp Val Leu Ile Gly Met Val Phe 
1               5                   10                  15      


Met His Ser Pro Leu Pro Gln Thr Thr Ala Glu Lys Ser Pro Gly Ala 
            20                  25                  30          


Tyr Phe Leu Pro Glu Phe Ala Leu Ser Pro Gln Gly Ser Phe Leu Glu 
        35                  40                  45              


Asp Thr Thr Gly Glu Gln Phe Leu Thr Tyr Arg Tyr Asp Asp Gln Thr 
    50                  55                  60                  


Ser Arg Asn Thr Arg Ser Asp Glu Asp Lys Asp Gly Asn Trp Asp Ala 
65                  70                  75                  80  


Trp Gly Asp Trp Ser Asp Cys Ser Arg Thr Cys Gly Gly Gly Ala Ser 
                85                  90                  95      


Tyr Ser Leu Arg Arg Cys Leu Thr Gly Arg Asn Cys Glu Gly Gln Asn 
            100                 105                 110         


Ile Arg Tyr Lys Thr Cys Ser Asn His Asp Cys Pro Pro Asp Ala Glu 
        115                 120                 125             


Asp Phe Arg Ala Gln Gln Cys Ser Ala Tyr Asn Asp Val Gln Tyr Gln 
    130                 135                 140                 


Gly His Tyr Tyr Glu Trp Leu Pro Arg Tyr Asn Asp Pro Ala Ala Pro 
145                 150                 155                 160 


Cys Ala Leu Lys Cys His Ala Gln Gly Gln Asn Leu Val Val Glu Leu 
                165                 170                 175     


Ala Pro Lys Val Leu Asp Gly Thr Arg Cys Asn Thr Asp Ser Leu Asp 
            180                 185                 190         


Met Cys Ile Ser Gly Ile Cys Gln Ala Val Gly Cys Asp Arg Gln Leu 
        195                 200                 205             


Gly Ser Asn Ala Lys Glu Asp Asn Cys Gly Val Cys Ala Gly Asp Gly 
    210                 215                 220                 


Ser Thr Cys Arg Leu Val Arg Gly Gln Ser Lys Ser His Val Ser Pro 
225                 230                 235                 240 


Glu Lys Arg Glu Glu Asn Val Ile Ala Val Pro Leu Gly Ser Arg Ser 
                245                 250                 255     


Val Arg Ile Thr Val Lys Gly Pro Ala His Leu Phe Ile Glu Ser Lys 
            260                 265                 270         


Thr Leu Gln Gly Ser Lys Gly Glu His Ser Phe Asn Ser Pro Gly Val 
        275                 280                 285             


Phe Leu Val Glu Asn Thr Thr Val Glu Phe Gln Arg Gly Ser Glu Arg 
    290                 295                 300                 


Gln Thr Phe Lys Ile Pro Gly Pro Leu Met Ala Asp Phe Ile Phe Lys 
305                 310                 315                 320 


Thr Arg Tyr Thr Ala Ala Lys Asp Ser Val Val Gln Phe Phe Phe Tyr 
                325                 330                 335     


Gln Pro Ile Ser His Gln Trp Arg Gln Thr Asp Phe Phe Pro Cys Thr 
            340                 345                 350         


Val Thr Cys Gly Gly Gly Tyr Gln Leu Asn Ser Ala Glu Cys Val Asp 
        355                 360                 365             


Ile Arg Leu Lys Arg Val Val Pro Asp His Tyr Cys His Tyr Tyr Pro 
    370                 375                 380                 


Glu Asn Val Lys Pro Lys Pro Lys Leu Lys Glu Cys Ser Met Asp Pro 
385                 390                 395                 400 


Cys Pro Ser Ser Asp Gly Phe Lys Glu Ile Met Pro Tyr Asp His Phe 
                405                 410                 415     


Gln Pro Leu Pro Arg Trp Glu His Asn Pro Trp Thr Ala Cys Ser Val 
            420                 425                 430         


Ser Cys Gly Gly Gly Ile Gln Arg Arg Ser Phe Val Cys Val Glu Glu 
        435                 440                 445             


Ser Met His Gly Glu Ile Leu Gln Val Glu Glu Trp Lys Cys Met Tyr 
    450                 455                 460                 


Ala Pro Lys Pro Lys Val Met Gln Thr Cys Asn Leu Phe Asp Cys Pro 
465                 470                 475                 480 


Lys Trp Ile Ala Met Glu Trp Ser Gln Cys Thr Val Thr Cys Gly Arg 
                485                 490                 495     


Gly Leu Arg Tyr Arg Val Val Leu Cys Ile Asn His Arg Gly Glu His 
            500                 505                 510         


Val Gly Gly Cys Asn Pro Gln Leu Lys Leu His Ile Lys Glu Glu Cys 
        515                 520                 525             


Val Ile Pro Ile Pro Cys Tyr Lys Pro Lys Glu Lys Ser Pro Val Glu 
    530                 535                 540                 


Ala Lys Leu Pro Trp Leu Lys Gln Ala Gln Glu Leu Glu Glu Thr Arg 
545                 550                 555                 560 


Ile Ala Thr Glu Glu Pro Thr Phe Ile Pro Glu Pro Trp Ser Ala Cys 
                565                 570                 575     


Ser Thr Thr Cys Gly Pro Gly Val Gln Val Arg Glu Val Lys Cys Arg 
            580                 585                 590         


Val Leu Leu Thr Phe Thr Gln Thr Glu Thr Glu Leu Pro Glu Glu Glu 
        595                 600                 605             


Cys Glu Gly Pro Lys Leu Pro Thr Glu Arg Pro Cys Leu Leu Glu Ala 
    610                 615                 620                 


Cys Asp Glu Ser Pro Ala Ser Arg Glu Leu Asp Ile Pro Leu Pro Glu 
625                 630                 635                 640 


Asp Ser Glu Thr Thr Tyr Asp Trp Glu Tyr Ala Gly Phe Thr Pro Cys 
                645                 650                 655     


Thr Ala Thr Cys Val Gly Gly His Gln Glu Ala Ile Ala Val Cys Leu 
            660                 665                 670         


His Ile Gln Thr Gln Gln Thr Val Asn Asp Ser Leu Cys Asp Met Val 
        675                 680                 685             


His Arg Pro Pro Ala Met Ser Gln Ala Cys Asn Thr Glu Pro Cys Pro 
    690                 695                 700                 


Pro Arg Trp His Val Gly Ser Trp Gly Pro Cys Ser Ala Thr Cys Gly 
705                 710                 715                 720 


Val Gly Ile Gln Thr Arg Asp Val Tyr Cys Leu His Pro Gly Glu Thr 
                725                 730                 735     


Pro Ala Pro Pro Glu Glu Cys Arg Asp Glu Lys Pro His Ala Leu Gln 
            740                 745                 750         


Ala Cys Asn Gln Phe Asp Cys Pro Pro Gly Trp His Ile Glu Glu Trp 
        755                 760                 765             


Gln Gln Cys Ser Arg Thr Cys Gly Gly Gly Thr Gln Asn Arg Arg Val 
    770                 775                 780                 


Thr Cys Arg Gln Leu Leu Thr Asp Gly Ser Phe Leu Asn Leu Ser Asp 
785                 790                 795                 800 


Glu Leu Cys Gln Gly Pro Lys Ala Ser Ser His Lys Ser Cys Ala Arg 
                805                 810                 815     


Thr Asp Cys Pro Pro His Leu Ala Val Gly Asp Trp Ser Lys Cys Ser 
            820                 825                 830         


Val Ser Cys Gly Val Gly Ile Gln Arg Arg Lys Gln Val Cys Gln Arg 
        835                 840                 845             


Leu Ala Ala Lys Gly Arg Arg Ile Pro Leu Ser Glu Met Met Cys Arg 
    850                 855                 860                 


Asp Leu Pro Gly Leu Pro Leu Val Arg Ser Cys Gln Met Pro Glu Cys 
865                 870                 875                 880 


Ser Lys Ile Lys Ser Glu Met Lys Thr Lys Leu Gly Glu Gln Gly Pro 
                885                 890                 895     


Gln Ile Leu Ser Val Gln Arg Val Tyr Ile Gln Thr Arg Glu Glu Lys 
            900                 905                 910         


Arg Ile Asn Leu Thr Ile Gly Ser Arg Ala Tyr Leu Leu Pro Asn Thr 
        915                 920                 925             


Ser Val Ile Ile Lys Cys Pro Val Arg Arg Phe Gln Lys Ser Leu Ile 
    930                 935                 940                 


Gln Trp Glu Lys Asp Gly Arg Cys Leu Gln Asn Ser Lys Arg Leu Gly 
945                 950                 955                 960 


Ile Thr Lys Ser Gly Ser Leu Lys Ile His Gly Leu Ala Ala Pro Asp 
                965                 970                 975     


Ile Gly Val Tyr Arg Cys Ile Ala Gly Ser Ala Gln Glu Thr Val Val 
            980                 985                 990         


Leu Lys Leu Ile Gly Thr Asp Asn  Arg Leu Ile Ala Arg  Pro Ala Leu 
        995                 1000                 1005             


Arg Glu  Pro Met Arg Glu Tyr  Pro Gly Met Asp His  Ser Glu Ala 
    1010                 1015                 1020             


Asn Ser  Leu Gly Val Thr Trp  His Lys Met Arg Gln  Met Trp Asn 
    1025                 1030                 1035             


Asn Lys  Asn Asp Leu Tyr Leu  Asp Asp Asp His Ile  Ser Asn Gln 
    1040                 1045                 1050             


Pro Phe  Leu Arg Ala Leu Leu  Gly His Cys Ser Asn  Ser Ala Gly 
    1055                 1060                 1065             


Ser Thr  Asn Ser Trp Glu Leu  Lys Asn Lys Gln Phe  Glu Ala Ala 
    1070                 1075                 1080             


Val Lys  Gln Gly Ala Tyr Ser  Met Asp Thr Ala Gln  Phe Asp Glu 
    1085                 1090                 1095             


Leu Ile  Arg Asn Met Ser Gln  Leu Met Glu Thr Gly  Glu Val Ser 
    1100                 1105                 1110             


Asp Asp  Leu Ala Ser Gln Leu  Ile Tyr Gln Leu Val  Ala Glu Leu 
    1115                 1120                 1125             


Ala Lys  Ala Gln Pro Thr His  Met Gln Trp Arg Gly  Ile Gln Glu 
    1130                 1135                 1140             


Glu Thr  Pro Pro Ala Ala Gln  Leu Arg Gly Glu Thr  Gly Ser Val 
    1145                 1150                 1155             


Ser Gln  Ser Ser His Ala Lys  Asn Ser Gly Lys Leu  Thr Phe Lys 
    1160                 1165                 1170             


Pro Lys  Gly Pro Val Leu Met  Arg Gln Ser Gln Pro  Pro Ser Ile 
    1175                 1180                 1185             


Ser Phe  Asn Lys Thr Ile Asn  Ser Arg Ile Gly Asn  Thr Val Tyr 
    1190                 1195                 1200             


Ile Thr  Lys Arg Thr Glu Val  Ile Asn Ile Leu Cys  Asp Leu Ile 
    1205                 1210                 1215             


Thr Pro  Ser Glu Ala Thr Tyr  Thr Trp Thr Lys Asp  Gly Thr Leu 
    1220                 1225                 1230             


Leu Gln  Pro Ser Val Lys Ile  Ile Leu Asp Gly Thr  Gly Lys Ile 
    1235                 1240                 1245             


Gln Ile  Gln Asn Pro Thr Arg  Lys Glu Gln Gly Ile  Tyr Glu Cys 
    1250                 1255                 1260             


Ser Val  Ala Asn His Leu Gly  Ser Asp Val Glu Ser  Ser Ser Val 
    1265                 1270                 1275             


Leu Tyr  Ala Glu Ala Pro Val  Ile Leu Ser Val Glu  Arg Asn Ile 
    1280                 1285                 1290             


Thr Lys  Pro Glu His Asn His  Leu Ser Val Val Val  Gly Gly Ile 
    1295                 1300                 1305             


Val Glu  Ala Ala Leu Gly Ala  Asn Val Thr Ile Arg  Cys Pro Val 
    1310                 1315                 1320             


Lys Gly  Val Pro Gln Pro Asn  Ile Thr Trp Leu Lys  Arg Gly Gly 
    1325                 1330                 1335             


Ser Leu  Ser Gly Asn Val Ser  Leu Leu Phe Asn Gly  Ser Leu Leu 
    1340                 1345                 1350             


Leu Gln  Asn Val Ser Leu Glu  Asn Glu Gly Thr Tyr  Val Cys Ile 
    1355                 1360                 1365             


Ala Thr  Asn Ala Leu Gly Lys  Ala Val Ala Thr Ser  Val Leu His 
    1370                 1375                 1380             


Leu Leu  Glu Arg Arg Trp Pro  Glu Ser Arg Ile Val  Phe Leu Gln 
    1385                 1390                 1395             


Gly His  Lys Lys Tyr Ile Leu  Gln Ala Thr Asn Thr  Arg Thr Asn 
    1400                 1405                 1410             


Ser Asn  Asp Pro Thr Gly Glu  Pro Pro Pro Gln Glu  Pro Phe Trp 
    1415                 1420                 1425             


Glu Pro  Gly Asn Trp Ser His  Cys Ser Ala Thr Cys  Gly His Leu 
    1430                 1435                 1440             


Gly Ala  Arg Ile Gln Arg Pro  Gln Cys Val Met Ala  Asn Gly Gln 
    1445                 1450                 1455             


Glu Val  Ser Glu Ala Leu Cys  Asp His Leu Gln Lys  Pro Leu Ala 
    1460                 1465                 1470             


Gly Phe  Glu Pro Cys Asn Ile  Arg Asp Cys Pro Ala  Arg Trp Phe 
    1475                 1480                 1485             


Thr Ser  Val Trp Ser Gln Cys  Ser Val Ser Cys Gly  Glu Gly Tyr 
    1490                 1495                 1500             


His Ser  Arg Gln Val Thr Cys  Lys Arg Thr Lys Ala  Asn Gly Thr 
    1505                 1510                 1515             


Val Gln  Val Val Ser Pro Arg  Ala Cys Ala Pro Lys  Asp Arg Pro 
    1520                 1525                 1530             


Leu Gly  Arg Lys Pro Cys Phe  Gly His Pro Cys Val  Gln Trp Glu 
    1535                 1540                 1545             


Pro Gly  Asn Arg Cys Pro Gly  Arg Cys Met Gly Arg  Ala Val Arg 
    1550                 1555                 1560             


Met Gln  Gln Arg His Thr Ala  Cys Gln His Asn Ser  Ser Asp Ser 
    1565                 1570                 1575             


Asn Cys  Asp Asp Arg Lys Arg  Pro Thr Leu Arg Arg  Asn Cys Thr 
    1580                 1585                 1590             


Ser Gly  Ala Cys Asp Val Cys  Trp His Thr Gly Pro  Trp Lys Pro 
    1595                 1600                 1605             


Cys Thr  Ala Ala Cys Gly Arg  Gly Phe Gln Ser Arg  Lys Val Asp 
    1610                 1615                 1620             


Cys Ile  His Thr Arg Ser Cys  Lys Pro Val Ala Lys  Arg His Cys 
    1625                 1630                 1635             


Val Gln  Lys Lys Lys Pro Ile  Ser Trp Arg His Cys  Leu Gly Pro 
    1640                 1645                 1650             


Ser Cys  Asp Arg Asp Cys Thr  Asp Thr Thr His Tyr  Cys Met Phe 
    1655                 1660                 1665             


Val Lys  His Leu Asn Leu Cys  Ser Leu Asp Arg Tyr  Lys Gln Arg 
    1670                 1675                 1680             


Cys Cys  Gln Ser Cys Gln Glu  Gly 
    1685                 1690     


<210>  387
<211>  1682
<212>  PRT
<213>  Homo Sapiens

<400>  387

Met Ala Ser Trp Thr Ser Pro Trp Trp Val Leu Ile Gly Met Val Phe 
1               5                   10                  15      


Met His Ser Pro Leu Pro Gln Thr Thr Ala Glu Lys Ser Pro Gly Ala 
            20                  25                  30          


Tyr Phe Leu Pro Glu Phe Ala Leu Ser Pro Gln Gly Ser Phe Leu Glu 
        35                  40                  45              


Asp Thr Thr Gly Glu Gln Phe Leu Thr Tyr Arg Tyr Asp Asp Gln Thr 
    50                  55                  60                  


Ser Arg Asn Thr Arg Ser Asp Glu Asp Lys Asp Gly Asn Trp Asp Ala 
65                  70                  75                  80  


Trp Gly Asp Trp Ser Asp Cys Ser Arg Thr Cys Gly Gly Gly Ala Ser 
                85                  90                  95      


Tyr Ser Leu Arg Arg Cys Leu Thr Gly Arg Asn Cys Glu Gly Gln Asn 
            100                 105                 110         


Ile Arg Tyr Lys Thr Cys Ser Asn His Asp Cys Pro Pro Asp Ala Glu 
        115                 120                 125             


Asp Phe Arg Ala Gln Gln Cys Ser Ala Tyr Asn Asp Val Gln Tyr Gln 
    130                 135                 140                 


Gly His Tyr Tyr Glu Trp Leu Pro Arg Tyr Asn Asp Pro Ala Ala Pro 
145                 150                 155                 160 


Cys Ala Leu Lys Cys His Ala Gln Gly Gln Asn Leu Val Val Glu Leu 
                165                 170                 175     


Ala Pro Lys Val Leu Asp Gly Thr Arg Cys Asn Thr Asp Ser Leu Asp 
            180                 185                 190         


Met Cys Ile Ser Gly Ile Cys Gln Ala Val Gly Cys Asp Arg Gln Leu 
        195                 200                 205             


Gly Ser Asn Ala Lys Glu Asp Asn Cys Gly Val Cys Ala Gly Asp Gly 
    210                 215                 220                 


Ser Thr Cys Arg Leu Val Arg Gly Gln Ser Lys Ser His Val Ser Pro 
225                 230                 235                 240 


Glu Lys Arg Glu Glu Asn Val Ile Ala Val Pro Leu Gly Ser Arg Ser 
                245                 250                 255     


Val Arg Ile Thr Val Lys Gly Pro Ala His Leu Phe Ile Glu Ser Lys 
            260                 265                 270         


Thr Leu Gln Gly Ser Lys Gly Glu His Ser Phe Asn Ser Pro Gly Val 
        275                 280                 285             


Phe Leu Val Glu Asn Thr Thr Val Glu Phe Gln Arg Gly Ser Glu Arg 
    290                 295                 300                 


Gln Thr Phe Lys Ile Pro Gly Pro Leu Met Ala Asp Phe Ile Phe Lys 
305                 310                 315                 320 


Thr Arg Tyr Thr Ala Ala Lys Asp Ser Val Val Gln Phe Phe Phe Tyr 
                325                 330                 335     


Gln Pro Ile Ser His Gln Trp Arg Gln Thr Asp Phe Phe Pro Cys Thr 
            340                 345                 350         


Val Thr Cys Gly Gly Gly Tyr Gln Leu Asn Ser Ala Glu Cys Val Asp 
        355                 360                 365             


Ile Arg Leu Lys Arg Val Val Pro Asp His Tyr Cys His Tyr Tyr Pro 
    370                 375                 380                 


Glu Asn Val Lys Pro Lys Pro Lys Leu Lys Glu Cys Ser Met Asp Pro 
385                 390                 395                 400 


Cys Pro Ser Ser Asp Gly Phe Lys Glu Ile Met Pro Tyr Asp His Phe 
                405                 410                 415     


Gln Pro Leu Pro Arg Trp Glu His Asn Pro Trp Thr Ala Cys Ser Val 
            420                 425                 430         


Ser Cys Gly Gly Gly Ile Gln Arg Arg Ser Phe Val Cys Val Glu Glu 
        435                 440                 445             


Ser Met His Gly Glu Ile Leu Gln Val Glu Glu Trp Lys Cys Met Tyr 
    450                 455                 460                 


Ala Pro Lys Pro Lys Val Met Gln Thr Cys Asn Leu Phe Asp Cys Pro 
465                 470                 475                 480 


Lys Trp Ile Ala Met Glu Trp Ser Gln Cys Thr Val Thr Cys Gly Arg 
                485                 490                 495     


Gly Leu Arg Tyr Arg Val Val Leu Cys Ile Asn His Arg Gly Glu His 
            500                 505                 510         


Val Gly Gly Cys Asn Pro Gln Leu Lys Leu His Ile Lys Glu Glu Cys 
        515                 520                 525             


Val Ile Pro Ile Pro Cys Tyr Lys Pro Lys Glu Lys Ser Pro Val Glu 
    530                 535                 540                 


Ala Lys Leu Pro Trp Leu Lys Gln Ala Gln Glu Leu Glu Glu Thr Arg 
545                 550                 555                 560 


Ile Ala Thr Glu Glu Pro Thr Phe Ile Pro Glu Pro Trp Ser Ala Cys 
                565                 570                 575     


Ser Thr Thr Cys Gly Pro Gly Val Gln Val Arg Glu Val Lys Cys Arg 
            580                 585                 590         


Val Leu Leu Thr Phe Thr Gln Thr Glu Thr Glu Leu Pro Glu Glu Glu 
        595                 600                 605             


Cys Glu Gly Pro Lys Leu Pro Thr Glu Arg Pro Cys Leu Leu Glu Ala 
    610                 615                 620                 


Cys Asp Glu Ser Pro Ala Ser Arg Glu Leu Asp Ile Pro Leu Pro Glu 
625                 630                 635                 640 


Asp Ser Glu Thr Thr Tyr Asp Trp Glu Tyr Ala Gly Phe Thr Pro Cys 
                645                 650                 655     


Thr Ala Thr Cys Val Gly Gly His Gln Glu Ala Ile Ala Val Cys Leu 
            660                 665                 670         


His Ile Gln Thr Gln Gln Thr Val Asn Asp Ser Leu Cys Asp Met Val 
        675                 680                 685             


His Arg Pro Pro Ala Met Ser Gln Ala Cys Asn Thr Glu Pro Cys Pro 
    690                 695                 700                 


Pro Arg Trp His Val Gly Ser Trp Gly Pro Cys Ser Ala Thr Cys Gly 
705                 710                 715                 720 


Val Gly Ile Gln Thr Arg Asp Val Tyr Cys Leu His Pro Gly Glu Thr 
                725                 730                 735     


Pro Ala Pro Pro Glu Glu Cys Arg Asp Glu Lys Pro His Ala Leu Gln 
            740                 745                 750         


Ala Cys Asn Gln Phe Asp Cys Pro Pro Gly Trp His Ile Glu Glu Trp 
        755                 760                 765             


Gln Gln Cys Ser Arg Thr Cys Gly Gly Gly Thr Gln Asn Arg Arg Val 
    770                 775                 780                 


Thr Cys Arg Gln Leu Leu Thr Asp Gly Ser Phe Leu Asn Leu Ser Asp 
785                 790                 795                 800 


Glu Leu Cys Gln Gly Pro Lys Ala Ser Ser His Lys Ser Cys Ala Arg 
                805                 810                 815     


Thr Asp Cys Pro Pro His Leu Ala Val Gly Asp Trp Ser Lys Cys Ser 
            820                 825                 830         


Val Ser Cys Gly Val Gly Ile Gln Arg Arg Lys Gln Val Cys Gln Arg 
        835                 840                 845             


Leu Ala Ala Lys Gly Arg Arg Ile Pro Leu Ser Glu Met Met Cys Arg 
    850                 855                 860                 


Asp Leu Pro Gly Leu Pro Leu Val Arg Ser Cys Gln Met Pro Glu Cys 
865                 870                 875                 880 


Ser Lys Ile Lys Ser Glu Met Lys Thr Lys Leu Gly Glu Gln Gly Pro 
                885                 890                 895     


Gln Ile Leu Ser Val Gln Arg Val Tyr Ile Gln Thr Arg Glu Glu Lys 
            900                 905                 910         


Arg Ile Asn Leu Thr Ile Gly Ser Arg Ala Tyr Leu Leu Pro Asn Thr 
        915                 920                 925             


Ser Val Ile Ile Lys Cys Pro Val Arg Arg Phe Gln Lys Ser Leu Ile 
    930                 935                 940                 


Gln Trp Glu Lys Asp Gly Arg Cys Leu Gln Asn Ser Lys Arg Leu Gly 
945                 950                 955                 960 


Ile Thr Lys Ser Gly Ser Leu Lys Ile His Gly Leu Ala Ala Pro Asp 
                965                 970                 975     


Ile Gly Val Tyr Arg Cys Ile Ala Gly Ser Ala Gln Glu Thr Val Val 
            980                 985                 990         


Leu Lys Leu Ile Gly Thr Asp Asn  Arg Leu Ile Ala Arg  Pro Ala Leu 
        995                 1000                 1005             


Arg Glu  Pro Met Arg Glu Tyr  Pro Gly Met Asp His  Ser Glu Ala 
    1010                 1015                 1020             


Asn Ser  Leu Gly Val Thr Trp  His Lys Met Arg Gln  Met Trp Asn 
    1025                 1030                 1035             


Asn Lys  Asn Asp Leu Tyr Leu  Asp Asp Asp His Ile  Ser Asn Gln 
    1040                 1045                 1050             


Pro Phe  Leu Arg Ala Leu Leu  Gly His Cys Ser Asn  Ser Ala Gly 
    1055                 1060                 1065             


Ser Thr  Asn Ser Trp Glu Leu  Lys Asn Lys Gln Phe  Glu Ala Ala 
    1070                 1075                 1080             


Val Lys  Gln Gly Ala Tyr Ser  Met Asp Thr Ala Gln  Phe Asp Glu 
    1085                 1090                 1095             


Leu Ile  Arg Asn Met Ser Gln  Leu Met Glu Thr Gly  Glu Val Ser 
    1100                 1105                 1110             


Asp Asp  Leu Ala Ser Gln Leu  Ile Tyr Gln Leu Val  Ala Glu Leu 
    1115                 1120                 1125             


Ala Lys  Ala Gln Pro Thr His  Met Gln Trp Arg Gly  Ile Gln Glu 
    1130                 1135                 1140             


Glu Thr  Pro Pro Ala Ala Gln  Leu Arg Gly Glu Thr  Gly Ser Val 
    1145                 1150                 1155             


Ser Gln  Ser Ser His Ala Lys  Asn Ser Gly Lys Leu  Thr Phe Lys 
    1160                 1165                 1170             


Pro Lys  Gly Pro Val Leu Met  Arg Gln Ser Gln Pro  Pro Ser Ile 
    1175                 1180                 1185             


Ser Phe  Asn Lys Thr Ile Asn  Ser Arg Ile Gly Asn  Thr Val Tyr 
    1190                 1195                 1200             


Ile Thr  Lys Arg Thr Glu Val  Ile Asn Ile Leu Cys  Asp Leu Ile 
    1205                 1210                 1215             


Thr Pro  Ser Glu Ala Thr Tyr  Thr Trp Thr Lys Asp  Gly Thr Leu 
    1220                 1225                 1230             


Leu Gln  Pro Ser Val Lys Ile  Ile Leu Asp Gly Thr  Gly Lys Ile 
    1235                 1240                 1245             


Gln Ile  Gln Asn Pro Thr Arg  Lys Glu Gln Gly Ile  Tyr Glu Cys 
    1250                 1255                 1260             


Ser Val  Ala Asn His Leu Gly  Ser Asp Val Glu Ser  Ser Ser Val 
    1265                 1270                 1275             


Leu Tyr  Ala Glu Ala Pro Val  Ile Leu Ser Val Glu  Arg Asn Ile 
    1280                 1285                 1290             


Thr Lys  Pro Glu His Asn His  Leu Ser Val Val Val  Gly Gly Ile 
    1295                 1300                 1305             


Val Glu  Ala Ala Leu Gly Ala  Asn Val Thr Ile Arg  Cys Pro Val 
    1310                 1315                 1320             


Lys Gly  Val Pro Gln Pro Asn  Ile Thr Trp Leu Lys  Arg Gly Gly 
    1325                 1330                 1335             


Ser Leu  Ser Gly Asn Val Ser  Leu Leu Phe Asn Gly  Ser Leu Leu 
    1340                 1345                 1350             


Leu Gln  Asn Val Ser Leu Glu  Asn Glu Gly Thr Tyr  Val Cys Ile 
    1355                 1360                 1365             


Ala Thr  Asn Ala Leu Gly Lys  Ala Val Ala Thr Ser  Val Leu His 
    1370                 1375                 1380             


Leu Leu  Glu Arg Arg Trp Pro  Glu Ser Arg Ile Val  Phe Leu Gln 
    1385                 1390                 1395             


Gly His  Lys Lys Tyr Ile Leu  Gln Ala Thr Asn Thr  Arg Thr Asn 
    1400                 1405                 1410             


Ser Asn  Asp Pro Thr Gly Glu  Pro Pro Pro Gln Glu  Pro Phe Trp 
    1415                 1420                 1425             


Glu Pro  Gly Asn Trp Ser His  Cys Ser Ala Thr Cys  Gly His Leu 
    1430                 1435                 1440             


Gly Ala  Arg Ile Gln Arg Pro  Gln Cys Val Met Ala  Asn Gly Gln 
    1445                 1450                 1455             


Glu Val  Ser Glu Ala Leu Cys  Asp His Leu Gln Lys  Pro Leu Ala 
    1460                 1465                 1470             


Gly Phe  Glu Pro Cys Asn Ile  Arg Asp Cys Pro Ala  Arg Trp Phe 
    1475                 1480                 1485             


Thr Ser  Val Trp Ser Gln Cys  Ser Val Ser Cys Gly  Glu Gly Tyr 
    1490                 1495                 1500             


His Ser  Arg Gln Val Thr Cys  Lys Arg Thr Lys Ala  Asn Gly Thr 
    1505                 1510                 1515             


Val Gln  Val Val Ser Pro Arg  Ala Cys Ala Pro Lys  Asp Arg Pro 
    1520                 1525                 1530             


Leu Gly  Arg Lys Pro Cys Phe  Gly His Pro Cys Val  Gln Trp Glu 
    1535                 1540                 1545             


Pro Gly  Asn Arg Cys Pro Gly  Arg Cys Met Gly Arg  Ala Val Arg 
    1550                 1555                 1560             


Met Gln  Gln Arg His Thr Ala  Cys Gln His Asn Ser  Ser Asp Ser 
    1565                 1570                 1575             


Asn Cys  Asp Asp Arg Lys Arg  Pro Thr Leu Arg Arg  Asn Cys Thr 
    1580                 1585                 1590             


Ser Gly  Ala Cys Asp Val Cys  Trp His Thr Gly Pro  Trp Lys Pro 
    1595                 1600                 1605             


Cys Thr  Ala Ala Cys Gly Arg  Gly Phe Gln Ser Arg  Lys Val Asp 
    1610                 1615                 1620             


Cys Ile  His Thr Arg Ser Cys  Lys Pro Val Ala Lys  Arg His Cys 
    1625                 1630                 1635             


Val Gln  Lys Lys Lys Pro Ile  Ser Trp Arg His Cys  Leu Gly Pro 
    1640                 1645                 1650             


Ser Cys  Asp Ser Thr Tyr Thr  Ser Gln Thr Ala Thr  Asn Lys Gly 
    1655                 1660                 1665             


Ala Ala  Ser His Val Lys Arg  Asp Lys Pro Leu Glu  Gly Ser 
    1670                 1675                 1680         


<210>  388
<211>  1074
<212>  PRT
<213>  Homo Sapiens

<400>  388

Met Glu Asn Trp Thr Gly Arg Pro Trp Leu Tyr Leu Leu Leu Leu Leu 
1               5                   10                  15      


Ser Leu Pro Gln Leu Cys Leu Asp Gln Glu Val Leu Ser Gly His Ser 
            20                  25                  30          


Leu Gln Thr Pro Thr Glu Glu Gly Gln Gly Pro Glu Gly Val Trp Gly 
        35                  40                  45              


Pro Trp Val Gln Trp Ala Ser Cys Ser Gln Pro Cys Gly Val Gly Val 
    50                  55                  60                  


Gln Arg Arg Ser Arg Thr Cys Gln Leu Pro Thr Val Gln Leu His Pro 
65                  70                  75                  80  


Ser Leu Pro Leu Pro Pro Arg Pro Pro Arg His Pro Glu Ala Leu Leu 
                85                  90                  95      


Pro Arg Gly Gln Gly Pro Arg Pro Gln Thr Ser Pro Glu Thr Leu Pro 
            100                 105                 110         


Leu Tyr Arg Thr Gln Ser Arg Gly Arg Gly Gly Pro Leu Arg Gly Pro 
        115                 120                 125             


Ala Ser His Leu Gly Arg Glu Glu Thr Gln Glu Ile Arg Ala Ala Arg 
    130                 135                 140                 


Arg Ser Arg Leu Arg Asp Pro Ile Lys Pro Gly Met Phe Gly Tyr Gly 
145                 150                 155                 160 


Arg Val Pro Phe Ala Leu Pro Leu His Arg Asn Arg Arg His Pro Arg 
                165                 170                 175     


Ser Pro Pro Arg Ser Glu Leu Ser Leu Ile Ser Ser Arg Gly Glu Glu 
            180                 185                 190         


Ala Ile Pro Ser Pro Thr Pro Arg Ala Glu Pro Phe Ser Ala Asn Gly 
        195                 200                 205             


Ser Pro Gln Thr Glu Leu Pro Pro Thr Glu Leu Ser Val His Thr Pro 
    210                 215                 220                 


Ser Pro Gln Ala Glu Pro Leu Ser Pro Glu Thr Ala Gln Thr Glu Val 
225                 230                 235                 240 


Ala Pro Arg Thr Arg Pro Ala Pro Leu Arg His His Pro Arg Ala Gln 
                245                 250                 255     


Ala Ser Gly Thr Glu Pro Pro Ser Pro Thr His Ser Leu Gly Glu Gly 
            260                 265                 270         


Gly Phe Phe Arg Ala Ser Pro Gln Pro Arg Arg Pro Ser Ser Gln Gly 
        275                 280                 285             


Trp Ala Ser Pro Gln Val Ala Gly Arg Arg Pro Asp Pro Phe Pro Ser 
    290                 295                 300                 


Val Pro Arg Gly Arg Gly Gln Gln Gly Gln Gly Pro Trp Gly Thr Gly 
305                 310                 315                 320 


Gly Thr Pro His Gly Pro Arg Leu Glu Pro Asp Pro Gln His Pro Gly 
                325                 330                 335     


Ala Trp Leu Pro Leu Leu Ser Asn Gly Pro His Ala Ser Ser Leu Trp 
            340                 345                 350         


Ser Leu Phe Ala Pro Ser Ser Pro Ile Pro Arg Cys Ser Gly Glu Ser 
        355                 360                 365             


Glu Gln Leu Arg Ala Cys Ser Gln Ala Pro Cys Pro Pro Glu Gln Pro 
    370                 375                 380                 


Asp Pro Arg Ala Leu Gln Cys Ala Ala Phe Asn Ser Gln Glu Phe Met 
385                 390                 395                 400 


Gly Gln Leu Tyr Gln Trp Glu Pro Phe Thr Glu Val Gln Gly Ser Gln 
                405                 410                 415     


Arg Cys Glu Leu Asn Cys Arg Pro Arg Gly Phe Arg Phe Tyr Val Arg 
            420                 425                 430         


His Thr Glu Lys Val Gln Asp Gly Thr Leu Cys Gln Pro Gly Ala Pro 
        435                 440                 445             


Asp Ile Cys Val Ala Gly Arg Cys Leu Ser Pro Gly Cys Asp Gly Ile 
    450                 455                 460                 


Leu Gly Ser Gly Arg Arg Pro Asp Gly Cys Gly Val Cys Gly Gly Asp 
465                 470                 475                 480 


Asp Ser Thr Cys Arg Leu Val Ser Gly Asn Leu Thr Asp Arg Gly Gly 
                485                 490                 495     


Pro Leu Gly Tyr Gln Lys Ile Leu Trp Ile Pro Ala Gly Ala Leu Arg 
            500                 505                 510         


Leu Gln Ile Ala Gln Leu Arg Pro Ser Ser Asn Tyr Leu Ala Leu Arg 
        515                 520                 525             


Gly Pro Gly Gly Arg Ser Ile Ile Asn Gly Asn Trp Ala Val Asp Pro 
    530                 535                 540                 


Pro Gly Ser Tyr Arg Ala Gly Gly Thr Val Phe Arg Tyr Asn Arg Pro 
545                 550                 555                 560 


Pro Arg Glu Glu Gly Lys Gly Glu Ser Leu Ser Ala Glu Gly Pro Thr 
                565                 570                 575     


Thr Gln Pro Val Asp Val Tyr Met Ile Phe Gln Glu Glu Asn Pro Gly 
            580                 585                 590         


Val Phe Tyr Gln Tyr Val Ile Ser Ser Pro Pro Pro Ile Leu Glu Asn 
        595                 600                 605             


Pro Thr Pro Glu Pro Pro Val Pro Gln Leu Gln Pro Glu Ile Leu Arg 
    610                 615                 620                 


Val Glu Pro Pro Leu Ala Pro Ala Pro Arg Pro Ala Arg Thr Pro Gly 
625                 630                 635                 640 


Thr Leu Gln Arg Gln Val Arg Ile Pro Gln Met Pro Ala Pro Pro His 
                645                 650                 655     


Pro Arg Thr Pro Leu Gly Ser Pro Ala Ala Tyr Trp Lys Arg Val Gly 
            660                 665                 670         


His Ser Ala Cys Ser Ala Ser Cys Gly Lys Gly Val Trp Arg Pro Ile 
        675                 680                 685             


Phe Leu Cys Ile Ser Arg Glu Ser Gly Glu Glu Leu Asp Glu Arg Ser 
    690                 695                 700                 


Cys Ala Ala Gly Ala Arg Pro Pro Ala Ser Pro Glu Pro Cys His Gly 
705                 710                 715                 720 


Thr Pro Cys Pro Pro Tyr Trp Glu Ala Gly Glu Trp Thr Ser Cys Ser 
                725                 730                 735     


Arg Ser Cys Gly Pro Gly Thr Gln His Arg Gln Leu Gln Cys Arg Gln 
            740                 745                 750         


Glu Phe Gly Gly Gly Gly Ser Ser Val Pro Pro Glu Arg Cys Gly His 
        755                 760                 765             


Leu Pro Arg Pro Asn Ile Thr Gln Ser Cys Gln Leu Arg Leu Cys Gly 
    770                 775                 780                 


His Trp Glu Val Gly Ser Pro Trp Ser Gln Cys Ser Val Arg Cys Gly 
785                 790                 795                 800 


Arg Gly Gln Arg Ser Arg Gln Val Arg Cys Val Gly Asn Asn Gly Asp 
                805                 810                 815     


Glu Val Ser Glu Gln Glu Cys Ala Ser Gly Pro Pro Gln Pro Pro Ser 
            820                 825                 830         


Arg Glu Ala Cys Asp Met Gly Pro Cys Thr Thr Ala Trp Phe His Ser 
        835                 840                 845             


Asp Trp Ser Ser Lys Cys Ser Ala Glu Cys Gly Thr Gly Ile Gln Arg 
    850                 855                 860                 


Arg Ser Val Val Cys Leu Gly Ser Gly Ala Ala Leu Gly Pro Gly Gln 
865                 870                 875                 880 


Gly Glu Ala Gly Ala Gly Thr Gly Gln Ser Cys Pro Thr Gly Ser Arg 
                885                 890                 895     


Pro Pro Asp Met Arg Ala Cys Ser Leu Gly Pro Cys Glu Arg Thr Trp 
            900                 905                 910         


Arg Trp Tyr Thr Gly Pro Trp Gly Glu Cys Ser Ser Glu Cys Gly Ser 
        915                 920                 925             


Gly Thr Gln Arg Arg Asp Ile Ile Cys Val Ser Lys Leu Gly Thr Glu 
    930                 935                 940                 


Phe Asn Val Thr Ser Pro Ser Asn Cys Ser His Leu Pro Arg Pro Pro 
945                 950                 955                 960 


Ala Leu Gln Pro Cys Gln Gly Gln Ala Cys Gln Asp Arg Trp Phe Ser 
                965                 970                 975     


Thr Pro Trp Ser Pro Cys Ser Arg Ser Cys Gln Gly Gly Thr Gln Thr 
            980                 985                 990         


Arg Glu Val Gln Cys Leu Ser Thr  Asn Gln Thr Leu Ser  Thr Arg Cys 
        995                 1000                 1005             


Pro Pro  Gln Leu Arg Pro Ser  Arg Lys Arg Pro Cys  Asn Ser Gln 
    1010                 1015                 1020             


Pro Cys  Ser Gln Arg Pro Asp  Asp Gln Cys Lys Asp  Ser Ser Pro 
    1025                 1030                 1035             


His Cys  Pro Leu Val Val Gln  Ala Arg Leu Cys Val  Tyr Pro Tyr 
    1040                 1045                 1050             


Tyr Thr  Ala Thr Cys Cys Arg  Ser Cys Ala His Val  Leu Glu Arg 
    1055                 1060                 1065             


Ser Pro  Gln Asp Pro Ser 
    1070                 


<210>  389
<211>  1097
<212>  PRT
<213>  Homo Sapiens

<400>  389

Met Glu Asn Trp Thr Gly Arg Pro Trp Leu Tyr Leu Leu Leu Leu Leu 
1               5                   10                  15      


Ser Leu Pro Gln Leu Cys Leu Asp Gln Glu Val Leu Ser Gly His Ser 
            20                  25                  30          


Leu Gln Thr Pro Thr Glu Glu Gly Gln Gly Pro Glu Gly Val Trp Gly 
        35                  40                  45              


Pro Trp Val Gln Trp Ala Ser Cys Ser Gln Pro Cys Gly Val Gly Val 
    50                  55                  60                  


Gln Arg Arg Ser Arg Thr Cys Gln Leu Pro Thr Val Gln Leu His Pro 
65                  70                  75                  80  


Ser Leu Pro Leu Pro Pro Arg Pro Pro Arg His Pro Glu Ala Leu Leu 
                85                  90                  95      


Pro Arg Gly Gln Gly Pro Arg Pro Gln Thr Ser Pro Glu Thr Leu Pro 
            100                 105                 110         


Leu Tyr Arg Thr Gln Ser Arg Gly Arg Gly Gly Pro Leu Arg Gly Pro 
        115                 120                 125             


Ala Ser His Leu Gly Arg Glu Glu Thr Gln Glu Ile Arg Ala Ala Arg 
    130                 135                 140                 


Arg Ser Arg Leu Arg Asp Pro Ile Lys Pro Gly Met Phe Gly Tyr Gly 
145                 150                 155                 160 


Arg Val Pro Phe Ala Leu Pro Leu His Arg Asn Arg Arg His Pro Arg 
                165                 170                 175     


Ser Pro Pro Arg Ser Glu Leu Ser Leu Ile Ser Ser Arg Gly Glu Glu 
            180                 185                 190         


Ala Ile Pro Ser Pro Thr Pro Arg Ala Glu Pro Phe Ser Ala Asn Gly 
        195                 200                 205             


Ser Pro Gln Thr Glu Leu Pro Pro Thr Glu Leu Ser Val His Thr Pro 
    210                 215                 220                 


Ser Pro Gln Ala Glu Pro Leu Ser Pro Glu Thr Ala Gln Thr Glu Val 
225                 230                 235                 240 


Ala Pro Arg Thr Arg Pro Ala Pro Leu Arg His His Pro Arg Ala Gln 
                245                 250                 255     


Ala Ser Gly Thr Glu Pro Pro Ser Pro Thr His Ser Leu Gly Glu Gly 
            260                 265                 270         


Gly Phe Phe Arg Ala Ser Pro Gln Pro Arg Arg Pro Ser Ser Gln Gly 
        275                 280                 285             


Trp Ala Ser Pro Gln Val Ala Gly Arg Arg Pro Asp Pro Phe Pro Ser 
    290                 295                 300                 


Val Pro Arg Gly Arg Gly Gln Gln Gly Gln Gly Pro Trp Gly Thr Gly 
305                 310                 315                 320 


Gly Thr Pro His Gly Pro Arg Leu Glu Pro Asp Pro Gln His Pro Gly 
                325                 330                 335     


Ala Trp Leu Pro Leu Leu Ser Asn Gly Pro His Ala Ser Ser Leu Trp 
            340                 345                 350         


Ser Leu Phe Ala Pro Ser Ser Pro Ile Pro Arg Cys Ser Gly Glu Ser 
        355                 360                 365             


Glu Gln Leu Arg Ala Cys Ser Gln Ala Pro Cys Pro Pro Glu Gln Pro 
    370                 375                 380                 


Asp Pro Arg Ala Leu Gln Cys Ala Ala Phe Asn Ser Gln Glu Phe Met 
385                 390                 395                 400 


Gly Gln Leu Tyr Gln Trp Glu Pro Phe Thr Glu Ala Pro Leu Leu Pro 
                405                 410                 415     


Leu Arg His Ala Phe Phe Leu Leu Pro Gly Ala Gly Ser Gly Asp Ser 
            420                 425                 430         


Thr Gly Val Gln Gly Ser Gln Arg Cys Glu Leu Asn Cys Arg Pro Arg 
        435                 440                 445             


Gly Phe Arg Phe Tyr Val Arg His Thr Glu Lys Val Gln Asp Gly Thr 
    450                 455                 460                 


Leu Cys Gln Pro Gly Ala Pro Asp Ile Cys Val Ala Gly Arg Cys Leu 
465                 470                 475                 480 


Ser Pro Gly Cys Asp Gly Ile Leu Gly Ser Gly Arg Arg Pro Asp Gly 
                485                 490                 495     


Cys Gly Val Cys Gly Gly Asp Asp Ser Thr Cys Arg Leu Val Ser Gly 
            500                 505                 510         


Asn Leu Thr Asp Arg Gly Gly Pro Leu Gly Tyr Gln Lys Ile Leu Trp 
        515                 520                 525             


Ile Pro Ala Gly Ala Leu Arg Leu Gln Ile Ala Gln Leu Arg Pro Ser 
    530                 535                 540                 


Ser Asn Tyr Leu Ala Leu Arg Gly Pro Gly Gly Arg Ser Ile Ile Asn 
545                 550                 555                 560 


Gly Asn Trp Ala Val Asp Pro Pro Gly Ser Tyr Arg Ala Gly Gly Thr 
                565                 570                 575     


Val Phe Arg Tyr Asn Arg Pro Pro Arg Glu Glu Gly Lys Gly Glu Ser 
            580                 585                 590         


Leu Ser Ala Glu Gly Pro Thr Thr Gln Pro Val Asp Val Tyr Met Ile 
        595                 600                 605             


Phe Gln Glu Glu Asn Pro Gly Val Phe Tyr Gln Tyr Val Ile Ser Ser 
    610                 615                 620                 


Pro Pro Pro Ile Leu Glu Asn Pro Thr Pro Glu Pro Pro Val Pro Gln 
625                 630                 635                 640 


Leu Gln Pro Glu Ile Leu Arg Val Glu Pro Pro Leu Ala Pro Ala Pro 
                645                 650                 655     


Arg Pro Ala Arg Thr Pro Gly Thr Leu Gln Arg Gln Val Arg Ile Pro 
            660                 665                 670         


Gln Met Pro Ala Pro Pro His Pro Arg Thr Pro Leu Gly Ser Pro Ala 
        675                 680                 685             


Ala Tyr Trp Lys Arg Val Gly His Ser Ala Cys Ser Ala Ser Cys Gly 
    690                 695                 700                 


Lys Gly Val Trp Arg Pro Ile Phe Leu Cys Ile Ser Arg Glu Ser Gly 
705                 710                 715                 720 


Glu Glu Leu Asp Glu Arg Ser Cys Ala Ala Gly Ala Arg Pro Pro Ala 
                725                 730                 735     


Ser Pro Glu Pro Cys His Gly Thr Pro Cys Pro Pro Tyr Trp Glu Ala 
            740                 745                 750         


Gly Glu Trp Thr Ser Cys Ser Arg Ser Cys Gly Pro Gly Thr Gln His 
        755                 760                 765             


Arg Gln Leu Gln Cys Arg Gln Glu Phe Gly Gly Gly Gly Ser Ser Val 
    770                 775                 780                 


Pro Pro Glu Arg Cys Gly His Leu Pro Arg Pro Asn Ile Thr Gln Ser 
785                 790                 795                 800 


Cys Gln Leu Arg Leu Cys Gly His Trp Glu Val Gly Ser Pro Trp Ser 
                805                 810                 815     


Gln Cys Ser Val Arg Cys Gly Arg Gly Gln Arg Ser Arg Gln Val Arg 
            820                 825                 830         


Cys Val Gly Asn Asn Gly Asp Glu Val Ser Glu Gln Glu Cys Ala Ser 
        835                 840                 845             


Gly Pro Pro Gln Pro Pro Ser Arg Glu Ala Cys Asp Met Gly Pro Cys 
    850                 855                 860                 


Thr Thr Ala Trp Phe His Ser Asp Trp Ser Ser Lys Cys Ser Ala Glu 
865                 870                 875                 880 


Cys Gly Thr Gly Ile Gln Arg Arg Ser Val Val Cys Leu Gly Ser Gly 
                885                 890                 895     


Ala Ala Leu Gly Pro Gly Gln Gly Glu Ala Gly Ala Gly Thr Gly Gln 
            900                 905                 910         


Ser Cys Pro Thr Gly Ser Arg Pro Pro Asp Met Arg Ala Cys Ser Leu 
        915                 920                 925             


Gly Pro Cys Glu Arg Thr Trp Arg Trp Tyr Thr Gly Pro Trp Gly Glu 
    930                 935                 940                 


Cys Ser Ser Glu Cys Gly Ser Gly Thr Gln Arg Arg Asp Ile Ile Cys 
945                 950                 955                 960 


Val Ser Lys Leu Gly Thr Glu Phe Asn Val Thr Ser Pro Ser Asn Cys 
                965                 970                 975     


Ser His Leu Pro Arg Pro Pro Ala Leu Gln Pro Cys Gln Gly Gln Ala 
            980                 985                 990         


Cys Gln Asp Arg Trp Phe Ser Thr  Pro Trp Ser Pro Cys  Ser Arg Ser 
        995                 1000                 1005             


Cys Gln  Gly Gly Thr Gln Thr  Arg Glu Val Gln Cys  Leu Ser Thr 
    1010                 1015                 1020             


Asn Gln  Thr Leu Ser Thr Arg  Cys Pro Pro Gln Leu  Arg Pro Ser 
    1025                 1030                 1035             


Arg Lys  Arg Pro Cys Asn Ser  Gln Pro Cys Ser Gln  Arg Pro Asp 
    1040                 1045                 1050             


Asp Gln  Cys Lys Asp Ser Ser  Pro His Cys Pro Leu  Val Val Gln 
    1055                 1060                 1065             


Ala Arg  Leu Cys Val Tyr Pro  Tyr Tyr Thr Ala Thr  Cys Cys Arg 
    1070                 1075                 1080             


Ser Cys  Ala His Val Leu Glu  Arg Ser Pro Gln Asp  Pro Ser 
    1085                 1090                 1095         


<210>  390
<211>  1074
<212>  PRT
<213>  Homo Sapiens

<400>  390

Met Glu Asn Trp Thr Gly Arg Pro Trp Leu Tyr Leu Leu Leu Leu Leu 
1               5                   10                  15      


Ser Leu Pro Gln Leu Cys Leu Asp Gln Glu Val Leu Ser Gly His Ser 
            20                  25                  30          


Leu Gln Thr Pro Thr Glu Glu Gly Gln Gly Pro Glu Gly Val Trp Gly 
        35                  40                  45              


Pro Trp Val Gln Trp Ala Ser Cys Ser Gln Pro Cys Gly Val Gly Val 
    50                  55                  60                  


Gln Arg Arg Ser Arg Thr Cys Gln Leu Pro Thr Val Gln Leu His Pro 
65                  70                  75                  80  


Ser Leu Pro Leu Pro Pro Arg Pro Pro Arg His Pro Glu Ala Leu Leu 
                85                  90                  95      


Pro Arg Gly Gln Gly Pro Arg Pro Gln Thr Ser Pro Glu Thr Leu Pro 
            100                 105                 110         


Leu Tyr Arg Thr Gln Ser Arg Gly Arg Gly Gly Pro Leu Arg Gly Pro 
        115                 120                 125             


Ala Ser His Leu Gly Arg Glu Glu Thr Gln Glu Ile Arg Ala Ala Arg 
    130                 135                 140                 


Arg Ser Arg Leu Arg Asp Pro Ile Lys Pro Gly Met Phe Gly Tyr Gly 
145                 150                 155                 160 


Arg Val Pro Phe Ala Leu Pro Leu His Arg Asn Arg Arg His Pro Arg 
                165                 170                 175     


Ser Pro Pro Arg Ser Glu Leu Ser Leu Ile Ser Ser Arg Gly Glu Glu 
            180                 185                 190         


Ala Ile Pro Ser Pro Thr Pro Arg Ala Glu Pro Phe Ser Ala Asn Gly 
        195                 200                 205             


Ser Pro Gln Thr Glu Leu Pro Pro Thr Glu Leu Ser Val His Thr Pro 
    210                 215                 220                 


Ser Pro Gln Ala Glu Pro Leu Ser Pro Glu Thr Ala Gln Thr Glu Val 
225                 230                 235                 240 


Ala Pro Arg Thr Arg Pro Ala Pro Leu Arg His His Pro Arg Ala Gln 
                245                 250                 255     


Ala Ser Gly Thr Glu Pro Pro Ser Pro Thr His Ser Leu Gly Glu Gly 
            260                 265                 270         


Gly Phe Phe Arg Ala Ser Pro Gln Pro Arg Arg Pro Ser Ser Gln Gly 
        275                 280                 285             


Trp Ala Ser Pro Gln Val Ala Gly Arg Arg Pro Asp Pro Phe Pro Ser 
    290                 295                 300                 


Val Pro Arg Gly Arg Gly Gln Gln Gly Gln Gly Pro Trp Gly Thr Gly 
305                 310                 315                 320 


Gly Thr Pro His Gly Pro Arg Leu Glu Pro Asp Pro Gln His Pro Gly 
                325                 330                 335     


Ala Trp Leu Pro Leu Leu Ser Asn Gly Pro His Ala Ser Ser Leu Trp 
            340                 345                 350         


Ser Leu Phe Ala Pro Ser Ser Pro Ile Pro Arg Cys Ser Gly Glu Ser 
        355                 360                 365             


Glu Gln Leu Arg Ala Cys Ser Gln Ala Pro Cys Pro Pro Glu Gln Pro 
    370                 375                 380                 


Asp Pro Arg Ala Leu Gln Cys Ala Ala Phe Asn Ser Gln Glu Phe Met 
385                 390                 395                 400 


Gly Gln Leu Tyr Gln Trp Glu Pro Phe Thr Glu Val Gln Gly Ser Gln 
                405                 410                 415     


Arg Cys Glu Leu Asn Cys Arg Pro Arg Gly Phe Arg Phe Tyr Val Arg 
            420                 425                 430         


His Thr Glu Lys Val Gln Asp Gly Thr Leu Cys Gln Pro Gly Ala Pro 
        435                 440                 445             


Asp Ile Cys Val Ala Gly Arg Cys Leu Ser Pro Gly Cys Asp Gly Ile 
    450                 455                 460                 


Leu Gly Ser Gly Arg Arg Pro Asp Gly Cys Gly Val Cys Gly Gly Asp 
465                 470                 475                 480 


Asp Ser Thr Cys Arg Leu Val Ser Gly Asn Leu Thr Asp Arg Gly Gly 
                485                 490                 495     


Pro Leu Gly Tyr Gln Lys Ile Leu Trp Ile Pro Ala Gly Ala Leu Arg 
            500                 505                 510         


Leu Gln Ile Ala Gln Leu Arg Pro Ser Ser Asn Tyr Leu Ala Leu Arg 
        515                 520                 525             


Gly Pro Gly Gly Arg Ser Ile Ile Asn Gly Asn Trp Ala Val Asp Pro 
    530                 535                 540                 


Pro Gly Ser Tyr Arg Ala Gly Gly Thr Val Phe Arg Tyr Asn Arg Pro 
545                 550                 555                 560 


Pro Arg Glu Glu Gly Lys Gly Glu Ser Leu Ser Ala Glu Gly Pro Thr 
                565                 570                 575     


Thr Gln Pro Val Asp Val Tyr Met Ile Phe Gln Glu Glu Asn Pro Gly 
            580                 585                 590         


Val Phe Tyr Gln Tyr Val Ile Ser Ser Pro Pro Pro Ile Leu Glu Asn 
        595                 600                 605             


Pro Thr Pro Glu Pro Pro Val Pro Gln Leu Gln Pro Glu Ile Leu Arg 
    610                 615                 620                 


Val Glu Pro Pro Leu Ala Pro Ala Pro Arg Pro Ala Arg Thr Pro Gly 
625                 630                 635                 640 


Thr Leu Gln Arg Gln Val Arg Ile Pro Gln Met Pro Ala Pro Pro His 
                645                 650                 655     


Pro Arg Thr Pro Leu Gly Ser Pro Ala Ala Tyr Trp Lys Arg Val Gly 
            660                 665                 670         


His Ser Ala Cys Ser Ala Ser Cys Gly Lys Gly Val Trp Arg Pro Ile 
        675                 680                 685             


Phe Leu Cys Ile Ser Arg Glu Ser Gly Glu Glu Leu Asp Glu Arg Ser 
    690                 695                 700                 


Cys Ala Ala Gly Ala Arg Pro Pro Ala Ser Pro Glu Pro Cys His Gly 
705                 710                 715                 720 


Thr Pro Cys Pro Pro Tyr Trp Glu Ala Gly Glu Trp Thr Ser Cys Ser 
                725                 730                 735     


Arg Ser Cys Gly Pro Gly Thr Gln His Arg Gln Leu Gln Cys Arg Gln 
            740                 745                 750         


Glu Phe Gly Gly Gly Gly Ser Ser Val Pro Pro Glu Arg Cys Gly His 
        755                 760                 765             


Leu Pro Arg Pro Asn Ile Thr Gln Ser Cys Gln Leu Arg Leu Cys Gly 
    770                 775                 780                 


His Trp Glu Val Gly Ser Pro Trp Ser Gln Cys Ser Val Arg Cys Gly 
785                 790                 795                 800 


Arg Gly Gln Arg Ser Arg Gln Val Arg Cys Val Gly Asn Asn Gly Asp 
                805                 810                 815     


Glu Val Ser Glu Gln Glu Cys Ala Ser Gly Pro Pro Gln Pro Pro Ser 
            820                 825                 830         


Arg Glu Ala Cys Asp Met Gly Pro Cys Thr Thr Ala Trp Phe His Ser 
        835                 840                 845             


Asp Trp Ser Ser Lys Cys Ser Ala Glu Cys Gly Thr Gly Ile Gln Arg 
    850                 855                 860                 


Arg Ser Val Val Cys Leu Gly Ser Gly Ala Ala Leu Gly Pro Gly Gln 
865                 870                 875                 880 


Gly Glu Ala Gly Ala Gly Thr Gly Gln Ser Cys Pro Thr Gly Ser Arg 
                885                 890                 895     


Pro Pro Asp Met Arg Ala Cys Ser Leu Gly Pro Cys Glu Arg Thr Trp 
            900                 905                 910         


Arg Trp Tyr Thr Gly Pro Trp Gly Glu Cys Ser Ser Glu Cys Gly Ser 
        915                 920                 925             


Gly Thr Gln Arg Arg Asp Ile Ile Cys Val Ser Lys Leu Gly Thr Glu 
    930                 935                 940                 


Phe Asn Val Thr Ser Pro Ser Asn Cys Ser His Leu Pro Arg Pro Pro 
945                 950                 955                 960 


Ala Leu Gln Pro Cys Gln Gly Gln Ala Cys Gln Asp Arg Trp Phe Ser 
                965                 970                 975     


Thr Pro Trp Ser Pro Cys Ser Arg Ser Cys Gln Gly Gly Thr Gln Thr 
            980                 985                 990         


Arg Glu Val Gln Cys Leu Ser Thr  Asn Gln Thr Leu Ser  Thr Arg Cys 
        995                 1000                 1005             


Pro Pro  Gln Leu Arg Pro Ser  Arg Lys Arg Pro Cys  Asn Ser Gln 
    1010                 1015                 1020             


Pro Cys  Ser Gln Arg Pro Asp  Asp Gln Cys Lys Asp  Ser Ser Pro 
    1025                 1030                 1035             


His Cys  Pro Leu Val Val Gln  Ala Arg Leu Cys Val  Tyr Pro Tyr 
    1040                 1045                 1050             


Tyr Thr  Ala Thr Cys Cys Arg  Ser Cys Ala His Val  Leu Glu Arg 
    1055                 1060                 1065             


Ser Pro  Gln Asp Pro Ser 
    1070                 


<210>  391
<211>  877
<212>  PRT
<213>  Homo Sapiens

<400>  391

Met Glu Asn Trp Thr Gly Arg Pro Trp Leu Tyr Leu Leu Leu Leu Leu 
1               5                   10                  15      


Ser Leu Pro Gln Leu Cys Leu Asp Gln Glu Val Leu Ser Gly His Ser 
            20                  25                  30          


Leu Gln Thr Pro Thr Glu Glu Gly Gln Gly Pro Glu Gly Val Trp Gly 
        35                  40                  45              


Pro Trp Val Gln Trp Ala Ser Cys Ser Gln Pro Cys Gly Val Gly Val 
    50                  55                  60                  


Gln Arg Arg Ser Arg Thr Cys Gln Leu Pro Thr Val Gln Leu His Pro 
65                  70                  75                  80  


Ser Leu Pro Leu Pro Pro Arg Pro Pro Arg His Pro Glu Ala Leu Leu 
                85                  90                  95      


Pro Arg Gly Gln Gly Pro Arg Pro Gln Thr Ser Pro Glu Thr Leu Pro 
            100                 105                 110         


Leu Tyr Arg Thr Gln Ser Arg Gly Arg Gly Gly Pro Leu Arg Gly Pro 
        115                 120                 125             


Ala Ser His Leu Gly Arg Glu Glu Thr Gln Glu Ile Arg Ala Ala Arg 
    130                 135                 140                 


Arg Ser Arg Leu Arg Asp Pro Ile Lys Pro Gly Met Phe Gly Tyr Gly 
145                 150                 155                 160 


Arg Val Pro Phe Ala Leu Pro Leu His Arg Asn Arg Arg His Pro Arg 
                165                 170                 175     


Ser Pro Pro Arg Ser Glu Leu Ser Leu Ile Ser Ser Arg Gly Glu Glu 
            180                 185                 190         


Ala Ile Pro Ser Pro Thr Pro Arg Ala Glu Pro Phe Ser Ala Asn Gly 
        195                 200                 205             


Ser Pro Gln Thr Glu Leu Pro Pro Thr Glu Leu Ser Val His Thr Pro 
    210                 215                 220                 


Ser Pro Gln Ala Glu Pro Leu Ser Pro Glu Thr Ala Gln Thr Glu Val 
225                 230                 235                 240 


Ala Pro Arg Thr Arg Pro Ala Pro Leu Arg His His Pro Arg Ala Gln 
                245                 250                 255     


Ala Ser Gly Thr Glu Pro Pro Ser Pro Thr His Ser Leu Gly Glu Gly 
            260                 265                 270         


Gly Phe Phe Arg Ala Ser Pro Gln Pro Arg Arg Pro Ser Ser Gln Gly 
        275                 280                 285             


Trp Ala Ser Pro Gln Val Ala Gly Arg Arg Pro Asp Pro Phe Pro Ser 
    290                 295                 300                 


Val Pro Arg Gly Arg Gly Gln Gln Gly Gln Gly Pro Trp Gly Thr Gly 
305                 310                 315                 320 


Gly Thr Pro His Gly Pro Arg Leu Glu Pro Asp Pro Gln His Pro Gly 
                325                 330                 335     


Ala Trp Leu Pro Leu Leu Ser Asn Gly Pro His Ala Ser Ser Leu Trp 
            340                 345                 350         


Ser Leu Phe Ala Pro Ser Ser Pro Ile Pro Arg Cys Ser Gly Glu Ser 
        355                 360                 365             


Glu Gln Leu Arg Ala Cys Ser Gln Ala Pro Cys Pro Pro Glu Gln Pro 
    370                 375                 380                 


Asp Pro Arg Ala Leu Gln Cys Ala Ala Phe Asn Ser Gln Glu Phe Met 
385                 390                 395                 400 


Gly Gln Leu Tyr Gln Trp Glu Pro Phe Thr Glu Val Gln Gly Ser Gln 
                405                 410                 415     


Arg Cys Glu Leu Asn Cys Arg Pro Arg Gly Phe Arg Phe Tyr Val Arg 
            420                 425                 430         


His Thr Glu Lys Val Gln Asp Gly Thr Leu Cys Gln Pro Gly Ala Pro 
        435                 440                 445             


Asp Ile Cys Val Ala Gly Arg Cys Leu Ser Pro Gly Cys Asp Gly Ile 
    450                 455                 460                 


Leu Gly Ser Gly Arg Arg Pro Asp Gly Cys Gly Val Cys Gly Gly Asp 
465                 470                 475                 480 


Asp Ser Thr Cys Arg Leu Val Ser Gly Asn Leu Thr Asp Arg Gly Gly 
                485                 490                 495     


Pro Leu Gly Tyr Gln Lys Ile Leu Trp Ile Pro Ala Gly Ala Leu Arg 
            500                 505                 510         


Leu Gln Ile Ala Gln Leu Arg Pro Ser Ser Asn Tyr Leu Ala Leu Arg 
        515                 520                 525             


Gly Pro Gly Gly Arg Ser Ile Ile Asn Gly Asn Trp Ala Val Asp Pro 
    530                 535                 540                 


Pro Gly Ser Tyr Arg Ala Gly Gly Thr Val Phe Arg Tyr Asn Arg Pro 
545                 550                 555                 560 


Pro Arg Glu Glu Gly Lys Gly Glu Ser Leu Ser Ala Glu Gly Pro Thr 
                565                 570                 575     


Thr Gln Pro Val Asp Val Tyr Met Ile Phe Gln Glu Glu Asn Pro Gly 
            580                 585                 590         


Val Phe Tyr Gln Tyr Val Ile Ser Ser Pro Pro Pro Ile Leu Glu Asn 
        595                 600                 605             


Pro Thr Pro Glu Pro Pro Val Pro Gln Leu Gln Pro Glu Ile Leu Arg 
    610                 615                 620                 


Val Glu Pro Pro Leu Ala Pro Ala Pro Arg Pro Ala Arg Thr Pro Gly 
625                 630                 635                 640 


Thr Leu Gln Arg Gln Val Arg Ile Pro Gln Met Pro Ala Pro Pro His 
                645                 650                 655     


Pro Arg Thr Pro Leu Gly Ser Pro Ala Ala Tyr Trp Lys Arg Val Gly 
            660                 665                 670         


His Ser Ala Cys Ser Ala Ser Cys Gly Lys Gly Val Trp Arg Pro Ile 
        675                 680                 685             


Phe Leu Cys Ile Ser Arg Glu Ser Gly Glu Glu Leu Asp Glu Arg Ser 
    690                 695                 700                 


Cys Ala Ala Gly Ala Arg Pro Pro Ala Ser Pro Glu Pro Cys His Gly 
705                 710                 715                 720 


Thr Pro Cys Pro Pro Tyr Trp Glu Ala Gly Glu Trp Thr Ser Cys Ser 
                725                 730                 735     


Arg Ser Cys Gly Pro Gly Thr Gln His Arg Gln Leu Gln Cys Arg Gln 
            740                 745                 750         


Glu Phe Gly Gly Gly Gly Ser Ser Val Pro Pro Glu Arg Cys Gly His 
        755                 760                 765             


Leu Pro Arg Pro Asn Ile Thr Gln Ser Cys Gln Leu Arg Leu Cys Gly 
    770                 775                 780                 


His Trp Glu Val Gly Ser Pro Trp Ser Gln Cys Ser Val Arg Cys Gly 
785                 790                 795                 800 


Arg Gly Gln Arg Ser Arg Gln Val Arg Cys Val Gly Asn Asn Gly Asp 
                805                 810                 815     


Glu Val Ser Glu Gln Glu Cys Ala Ser Gly Pro Pro Gln Pro Pro Ser 
            820                 825                 830         


Arg Glu Ala Cys Asp Met Gly Pro Cys Thr Thr Ala Trp Phe His Ser 
        835                 840                 845             


Asp Trp Ser Ser Lys Val Ser Pro Glu Pro Pro Ala Ile Ser Cys Ile 
    850                 855                 860                 


Leu Gly Asn His Ala Gln Asp Thr Ser Ala Phe Pro Ala 
865                 870                 875         


<210>  392
<211>  471
<212>  PRT
<213>  Homo Sapiens

<400>  392

Met Asp Ser Ala Pro Leu Phe Pro Arg Pro His Leu Phe Gln Asn Leu 
1               5                   10                  15      


Leu Leu Phe Leu Trp Ala Leu Leu Asn Cys Gly Leu Gly Val Ser Ala 
            20                  25                  30          


Gln Gly Pro Gly Glu Trp Thr Pro Trp Val Ser Trp Thr Arg Cys Ser 
        35                  40                  45              


Ser Ser Cys Gly Arg Gly Val Ser Val Arg Ser Arg Arg Cys Leu Arg 
    50                  55                  60                  


Leu Pro Gly Glu Glu Pro Cys Trp Gly Asp Ser His Glu Tyr Arg Leu 
65                  70                  75                  80  


Cys Gln Leu Pro Asp Cys Pro Pro Gly Ala Val Pro Phe Arg Asp Leu 
                85                  90                  95      


Gln Cys Ala Leu Tyr Asn Gly Arg Pro Val Leu Gly Thr Gln Lys Thr 
            100                 105                 110         


Tyr Gln Trp Val Pro Phe His Gly Ala Pro Asn Gln Cys Asp Leu Asn 
        115                 120                 125             


Cys Leu Ala Glu Gly His Ala Phe Tyr His Ser Phe Gly Arg Val Leu 
    130                 135                 140                 


Asp Gly Thr Ala Cys Ser Pro Gly Ala Gln Gly Val Cys Val Ala Gly 
145                 150                 155                 160 


Arg Cys Leu Ser Ala Gly Cys Asp Gly Leu Leu Gly Ser Gly Ala Leu 
                165                 170                 175     


Glu Asp Arg Cys Gly Arg Cys Gly Gly Ala Asn Asp Ser Cys Leu Phe 
            180                 185                 190         


Val Gln Arg Val Phe Arg Asp Ala Gly Ala Phe Ala Gly Tyr Trp Asn 
        195                 200                 205             


Val Thr Leu Ile Pro Glu Gly Ala Arg His Ile Arg Val Glu His Arg 
    210                 215                 220                 


Ser Arg Asn His Leu Ala Leu Met Gly Gly Asp Gly Arg Tyr Val Leu 
225                 230                 235                 240 


Asn Gly His Trp Val Val Ser Pro Pro Gly Thr Tyr Glu Ala Ala Gly 
                245                 250                 255     


Thr His Val Val Tyr Thr Arg Asp Thr Gly Pro Gln Glu Thr Leu Gln 
            260                 265                 270         


Ala Ala Gly Pro Thr Ser His Asp Leu Leu Leu Gln Val Leu Leu Gln 
        275                 280                 285             


Glu Pro Asn Pro Gly Ile Glu Phe Glu Phe Trp Leu Pro Arg Glu Arg 
    290                 295                 300                 


Tyr Ser Pro Phe Gln Ala Arg Val Gln Ala Leu Gly Trp Pro Leu Arg 
305                 310                 315                 320 


Gln Pro Gln Pro Arg Gly Val Glu Pro Gln Pro Pro Ala Ala Pro Ala 
                325                 330                 335     


Val Thr Pro Ala Gln Thr Pro Thr Leu Ala Pro Asp Pro Cys Pro Pro 
            340                 345                 350         


Cys Pro Asp Thr Arg Gly Arg Ala His Arg Leu Leu His Tyr Cys Gly 
        355                 360                 365             


Ser Asp Phe Val Phe Gln Ala Arg Val Leu Gly His His His Gln Ala 
    370                 375                 380                 


Gln Glu Thr Arg Tyr Glu Val Arg Ile Gln Leu Val Tyr Lys Asn Arg 
385                 390                 395                 400 


Ser Pro Leu Arg Ala Arg Glu Tyr Val Trp Ala Pro Gly His Cys Pro 
                405                 410                 415     


Cys Pro Met Leu Ala Pro His Arg Asp Tyr Leu Met Ala Val Gln Arg 
            420                 425                 430         


Leu Val Ser Pro Asp Gly Thr Gln Asp Gln Leu Leu Leu Pro His Ala 
        435                 440                 445             


Gly Tyr Ala Arg Pro Trp Ser Pro Ala Glu Asp Ser Arg Ile Arg Leu 
    450                 455                 460                 


Thr Ala Arg Arg Cys Pro Gly 
465                 470     


<210>  393
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  393

Met Gly Gly Asp Gly Arg Tyr Val Leu Asn Gly His Trp Val Val Ser 
1               5                   10                  15      


Pro Pro Gly Thr Tyr Glu Ala Ala Gly Thr His Val Val Tyr Thr Arg 
            20                  25                  30          


Asp Thr Gly Pro Gln Glu Thr Leu Gln Ala Ala Gly Pro Thr Ser His 
        35                  40                  45              


Asp Leu Leu Leu Gln Val Leu Leu Gln Glu Pro Asn Pro Gly Ile Glu 
    50                  55                  60                  


Phe Glu Phe Trp Leu Pro Arg Glu Arg Tyr Ser Pro Phe Gln Ala Arg 
65                  70                  75                  80  


Val Gln Ala Leu Gly Trp Pro Leu Arg Gln Pro Gln Pro Arg Gly Val 
                85                  90                  95      


Glu Pro Gln Pro Pro Ala Ala Pro Ala Val Thr Pro Ala Gln Thr Pro 
            100                 105                 110         


Thr Leu Ala Pro Gly Pro Ser Ala Gly Pro Pro Pro Pro Gly Pro Gly 
        115                 120                 125             


Asp Pro Leu 
    130     


<210>  394
<211>  130
<212>  PRT
<213>  Homo Sapiens

<400>  394

Met Gly Lys Leu Arg Pro Gly Arg Val Glu Trp Leu Ala Ser Gly His 
1               5                   10                  15      


Thr Glu Arg Pro His Leu Phe Gln Asn Leu Leu Leu Phe Leu Trp Ala 
            20                  25                  30          


Leu Leu Asn Cys Gly Leu Gly Val Ser Ala Gln Gly Pro Gly Glu Trp 
        35                  40                  45              


Thr Pro Trp Val Ser Trp Thr Arg Cys Ser Ser Ser Cys Gly Arg Gly 
    50                  55                  60                  


Val Ser Val Arg Ser Arg Arg Cys Leu Arg Leu Pro Gly Glu Glu Pro 
65                  70                  75                  80  


Cys Trp Gly Asp Ser His Glu Tyr Arg Leu Cys Gln Leu Pro Asp Cys 
                85                  90                  95      


Pro Pro Gly Ala Val Pro Phe Arg Asp Leu Gln Cys Ala Leu Tyr Asn 
            100                 105                 110         


Gly Arg Pro Val Leu Gly Thr Gln Lys Thr Tyr Gln Trp Val Pro Phe 
        115                 120                 125             


His Gly 
    130 


<210>  395
<211>  141
<212>  PRT
<213>  Homo Sapiens

<400>  395

Met Gly Lys Leu Arg Pro Gly Arg Val Glu Trp Leu Ala Ser Gly His 
1               5                   10                  15      


Thr Glu Arg Pro His Leu Phe Gln Asn Leu Leu Leu Phe Leu Trp Ala 
            20                  25                  30          


Leu Leu Asn Cys Gly Leu Gly Val Ser Ala Gln Gly Pro Gly Glu Trp 
        35                  40                  45              


Thr Pro Trp Val Ser Trp Thr Arg Cys Ser Ser Ser Cys Gly Arg Gly 
    50                  55                  60                  


Val Ser Val Arg Ser Arg Arg Cys Leu Arg Leu Pro Gly Glu Glu Pro 
65                  70                  75                  80  


Cys Trp Gly Asp Ser His Glu Tyr Arg Leu Cys Gln Leu Pro Asp Cys 
                85                  90                  95      


Pro Pro Gly Ala Val Pro Phe Arg Asp Leu Gln Cys Ala Leu Tyr Asn 
            100                 105                 110         


Gly Arg Pro Val Leu Gly Thr Gln Lys Thr Tyr Gln Trp Val Pro Phe 
        115                 120                 125             


His Gly Ala Pro Asn Gln Cys Asp Leu Asn Cys Leu Ala 
    130                 135                 140     


<210>  396
<211>  210
<212>  PRT
<213>  Homo Sapiens

<400>  396

Met Gly Lys Leu Arg Pro Gly Arg Val Glu Trp Leu Ala Ser Gly His 
1               5                   10                  15      


Thr Glu Arg Pro His Leu Phe Gln Asn Leu Leu Leu Phe Leu Trp Ala 
            20                  25                  30          


Leu Leu Asn Cys Gly Leu Gly Val Ser Ala Gln Gly Pro Gly Glu Trp 
        35                  40                  45              


Thr Pro Trp Val Ser Trp Thr Arg Cys Ser Ser Ser Cys Gly Arg Gly 
    50                  55                  60                  


Val Ser Val Arg Ser Arg Arg Cys Leu Arg Leu Pro Gly Glu Glu Pro 
65                  70                  75                  80  


Cys Trp Gly Asp Ser His Glu Tyr Arg Leu Cys Gln Leu Pro Asp Cys 
                85                  90                  95      


Pro Pro Gly Ala Val Pro Phe Arg Asp Leu Gln Cys Ala Leu Tyr Asn 
            100                 105                 110         


Gly Arg Pro Val Leu Gly Thr Gln Lys Thr Tyr Gln Trp Val Pro Phe 
        115                 120                 125             


His Gly Ala Pro Asn Gln Cys Asp Leu Asn Cys Leu Ala Glu Gly His 
    130                 135                 140                 


Ala Phe Tyr His Ser Phe Gly Arg Val Leu Asp Gly Thr Ala Cys Ser 
145                 150                 155                 160 


Pro Gly Ala Gln Gly Val Cys Val Ala Gly Arg Cys Leu Ser Ala Gly 
                165                 170                 175     


Cys Asp Gly Leu Leu Gly Ser Gly Ala Leu Glu Asp Arg Cys Gly Arg 
            180                 185                 190         


Cys Gly Gly Ala Asn Asp Ser Cys Leu Phe Val Gln Arg Val Phe Arg 
        195                 200                 205             


Asp Ala 
    210 


<210>  397
<211>  135
<212>  PRT
<213>  Homo Sapiens

<400>  397

Arg His Ile Arg Val Glu His Arg Ser Arg Asn His Leu Gly Ile Leu 
1               5                   10                  15      


Gly Ser Leu Met Gly Gly Asp Gly Arg Tyr Val Leu Asn Gly His Trp 
            20                  25                  30          


Val Val Ser Pro Pro Gly Thr Tyr Glu Ala Ala Gly Thr His Val Val 
        35                  40                  45              


Tyr Thr Arg Asp Thr Gly Pro Gln Glu Thr Leu Gln Ala Ala Gly Pro 
    50                  55                  60                  


Thr Ser His Asp Leu Leu Leu Gln Val Leu Leu Gln Glu Pro Asn Pro 
65                  70                  75                  80  


Gly Ile Glu Phe Glu Phe Trp Leu Pro Arg Glu Arg Tyr Ser Pro Phe 
                85                  90                  95      


Gln Ala Arg Val Gln Ala Leu Gly Trp Pro Leu Arg Gln Pro Gln Pro 
            100                 105                 110         


Arg Gly Val Glu Pro Gln Pro Pro Ala Ala Pro Ala Val Thr Pro Ala 
        115                 120                 125             


Gln Thr Pro Thr Leu Ala Pro 
    130                 135 


<210>  398
<211>  455
<212>  PRT
<213>  Homo Sapiens

<400>  398

Met Ala Arg Lys Ala Leu Lys Leu Ala Ser Trp Thr Ser Met Ala Leu 
1               5                   10                  15      


Ala Ala Ser Gly Ile Tyr Phe Tyr Ser Asn Lys Tyr Leu Asp Pro Asn 
            20                  25                  30          


Asp Phe Gly Ala Val Arg Val Gly Arg Ala Val Ala Thr Thr Ala Val 
        35                  40                  45              


Ile Ser Tyr Asp Tyr Leu Thr Ser Leu Lys Ser Val Pro Tyr Gly Ser 
    50                  55                  60                  


Glu Glu Tyr Leu Gln Leu Arg Ser Lys Ile His Asp Leu Phe Gln Ser 
65                  70                  75                  80  


Phe Asp Asp Thr Pro Leu Gly Thr Ala Ser Leu Ala Gln Val His Lys 
                85                  90                  95      


Ala Val Leu His Asp Gly Arg Thr Val Ala Val Lys Val Gln His Pro 
            100                 105                 110         


Lys Val Arg Ala Gln Ser Ser Lys Asp Ile Leu Leu Met Glu Val Leu 
        115                 120                 125             


Val Leu Ala Val Lys Gln Leu Phe Pro Glu Phe Glu Phe Met Trp Leu 
    130                 135                 140                 


Val Asp Glu Ala Lys Lys Asn Leu Pro Leu Glu Leu Asp Phe Leu Asn 
145                 150                 155                 160 


Glu Gly Arg Asn Ala Glu Lys Val Ser Gln Met Leu Arg His Phe Asp 
                165                 170                 175     


Phe Leu Lys Val Pro Arg Ile His Trp Asp Leu Ser Thr Glu Arg Val 
            180                 185                 190         


Leu Leu Met Glu Phe Val Asp Gly Gly Gln Val Asn Asp Arg Asp Tyr 
        195                 200                 205             


Met Glu Arg Asn Lys Ile Asp Val Asn Glu Ile Ser Arg His Leu Gly 
    210                 215                 220                 


Lys Met Tyr Ser Glu Met Ile Phe Val Asn Gly Phe Val His Cys Asp 
225                 230                 235                 240 


Pro His Pro Gly Asn Val Leu Val Arg Lys His Pro Gly Thr Gly Lys 
                245                 250                 255     


Ala Glu Ile Val Leu Leu Asp His Gly Leu Tyr Gln Met Leu Thr Glu 
            260                 265                 270         


Glu Phe Arg Leu Asn Tyr Cys His Leu Trp Gln Ser Leu Ile Trp Thr 
        275                 280                 285             


Asp Met Lys Arg Val Lys Glu Tyr Ser Gln Arg Leu Gly Ala Gly Asp 
    290                 295                 300                 


Leu Tyr Pro Leu Phe Ala Cys Met Leu Thr Ala Arg Ser Trp Asp Ser 
305                 310                 315                 320 


Val Asn Arg Gly Ile Ser Gln Ala Pro Val Thr Ala Thr Glu Asp Leu 
                325                 330                 335     


Glu Ile Arg Asn Asn Ala Ala Asn Tyr Leu Pro Gln Ile Ser His Leu 
            340                 345                 350         


Leu Asn His Val Pro Arg Gln Met Leu Leu Ile Leu Lys Thr Asn Asp 
        355                 360                 365             


Leu Leu Arg Gly Ile Glu Ala Ala Leu Gly Thr Arg Ala Ser Ala Ser 
    370                 375                 380                 


Ser Phe Leu Asn Met Ser Arg Cys Cys Ile Arg Ala Leu Ala Glu His 
385                 390                 395                 400 


Lys Lys Lys Asn Thr Cys Ser Phe Phe Arg Arg Thr Gln Ile Ser Phe 
                405                 410                 415     


Ser Glu Ala Phe Asn Leu Trp Gln Ile Asn Leu His Glu Leu Ile Leu 
            420                 425                 430         


Arg Val Lys Gly Leu Lys Leu Ala Asp Arg Val Leu Ala Leu Ile Cys 
        435                 440                 445             


Trp Leu Phe Pro Ala Pro Leu 
    450                 455 


<210>  399
<211>  122
<212>  PRT
<213>  Homo Sapiens

<400>  399

Met Ala Arg Lys Ala Leu Lys Leu Ala Ser Trp Thr Ser Met Ala Leu 
1               5                   10                  15      


Ala Ala Ser Gly Ile Tyr Phe Tyr Ser Asn Lys Tyr Leu Asp Pro Asn 
            20                  25                  30          


Asp Phe Gly Ala Val Arg Val Gly Arg Ala Val Ala Thr Thr Ala Val 
        35                  40                  45              


Ile Ser Tyr Asp Tyr Leu Thr Ser Leu Lys Ser Val Pro Tyr Gly Ser 
    50                  55                  60                  


Glu Glu Tyr Leu Gln Leu Arg Ser Lys Ser Leu Ala Val Ser Pro Arg 
65                  70                  75                  80  


Leu Glu Cys Ile Gly Val Ile Ser Ala His Cys Asn Leu Tyr Leu Leu 
                85                  90                  95      


Gly Ser Ser Asp Ser Pro Ala Ser Ala Ser Gln Val Ala Gly Thr Thr 
            100                 105                 110         


Gly Ala Pro Ser Leu Cys Gln Ala Ser Leu 
        115                 120         


<210>  400
<211>  266
<212>  PRT
<213>  Homo Sapiens

<400>  400

Met Ala Arg Lys Ala Leu Lys Leu Ala Ser Trp Thr Ser Met Ala Leu 
1               5                   10                  15      


Ala Ala Ser Gly Ile Tyr Phe Tyr Ser Asn Lys Tyr Leu Asp Pro Asn 
            20                  25                  30          


Asp Phe Gly Ala Val Arg Val Gly Arg Ala Val Ala Thr Thr Ala Val 
        35                  40                  45              


Ile Ser Tyr Asp Tyr Leu Thr Ser Leu Lys Ser Val Pro Tyr Gly Ser 
    50                  55                  60                  


Glu Glu Tyr Leu Gln Leu Arg Ser Lys Val His Leu Arg Ser Ala Arg 
65                  70                  75                  80  


Arg Leu Cys Glu Leu Cys Cys Ala Asn Arg Gly Thr Phe Ile Lys Val 
                85                  90                  95      


Gly Gln His Leu Gly Ala Leu Asp Tyr Leu Leu Pro Glu Glu Tyr Thr 
            100                 105                 110         


Ser Thr Leu Lys Val Leu His Ser Gln Ala Pro Gln Ser Ser Met Gln 
        115                 120                 125             


Glu Ile Arg Gln Val Ile Arg Glu Asp Leu Gly Lys Glu Ile His Asp 
    130                 135                 140                 


Leu Phe Gln Ser Phe Asp Asp Thr Pro Leu Gly Thr Ala Ser Leu Ala 
145                 150                 155                 160 


Gln Val His Lys Ala Val Leu His Asp Gly Arg Thr Val Ala Val Lys 
                165                 170                 175     


Val Gln His Pro Lys Val Arg Ala Gln Ser Ser Lys Asp Ile Leu Leu 
            180                 185                 190         


Met Glu Val Leu Val Leu Ala Val Lys Gln Leu Phe Pro Glu Phe Glu 
        195                 200                 205             


Phe Met Trp Leu Val Asp Glu Ala Lys Lys Asn Leu Pro Leu Glu Leu 
    210                 215                 220                 


Asp Phe Leu Asn Glu Gly Arg Asn Ala Glu Lys Val Ser Gln Met Leu 
225                 230                 235                 240 


Arg His Phe Asp Phe Leu Lys Ile Ser Arg His Leu Gly Lys Met Tyr 
                245                 250                 255     


Ser Glu Met Ile Phe Val Asn Gly Phe Val 
            260                 265     


<210>  401
<211>  523
<212>  PRT
<213>  Homo Sapiens

<400>  401

Met Ala Arg Lys Ala Leu Lys Leu Ala Ser Trp Thr Ser Met Ala Leu 
1               5                   10                  15      


Ala Ala Ser Gly Ile Tyr Phe Tyr Ser Asn Lys Tyr Leu Asp Pro Asn 
            20                  25                  30          


Asp Phe Gly Ala Val Arg Val Gly Arg Ala Val Ala Thr Thr Ala Val 
        35                  40                  45              


Ile Ser Tyr Asp Tyr Leu Thr Ser Leu Lys Ser Val Pro Tyr Gly Ser 
    50                  55                  60                  


Glu Glu Tyr Leu Gln Leu Arg Ser Lys Val His Leu Arg Ser Ala Arg 
65                  70                  75                  80  


Arg Leu Cys Glu Leu Cys Cys Ala Asn Arg Gly Thr Phe Ile Lys Val 
                85                  90                  95      


Gly Gln His Leu Gly Ala Leu Asp Tyr Leu Leu Pro Glu Glu Tyr Thr 
            100                 105                 110         


Ser Thr Leu Lys Val Leu His Ser Gln Ala Pro Gln Ser Ser Met Gln 
        115                 120                 125             


Glu Ile Arg Gln Val Ile Arg Glu Asp Leu Gly Lys Glu Ile His Asp 
    130                 135                 140                 


Leu Phe Gln Ser Phe Asp Asp Thr Pro Leu Gly Thr Ala Ser Leu Ala 
145                 150                 155                 160 


Gln Val His Lys Ala Val Leu His Asp Gly Arg Thr Val Ala Val Lys 
                165                 170                 175     


Val Gln His Pro Lys Val Arg Ala Gln Ser Ser Lys Asp Ile Leu Leu 
            180                 185                 190         


Met Glu Val Leu Val Leu Ala Val Lys Gln Leu Phe Pro Glu Phe Glu 
        195                 200                 205             


Phe Met Trp Leu Val Asp Glu Ala Lys Lys Asn Leu Pro Leu Glu Leu 
    210                 215                 220                 


Asp Phe Leu Asn Glu Gly Arg Asn Ala Glu Lys Val Ser Gln Met Leu 
225                 230                 235                 240 


Arg His Phe Asp Phe Leu Lys Val Pro Arg Ile His Trp Asp Leu Ser 
                245                 250                 255     


Thr Glu Arg Val Leu Leu Met Glu Phe Val Asp Gly Gly Gln Val Asn 
            260                 265                 270         


Asp Arg Asp Tyr Met Glu Arg Asn Lys Ile Asp Val Asn Glu Ile Ser 
        275                 280                 285             


Arg His Leu Gly Lys Met Tyr Ser Glu Met Ile Phe Val Asn Gly Phe 
    290                 295                 300                 


Val His Cys Asp Pro His Pro Gly Asn Val Leu Val Arg Lys His Pro 
305                 310                 315                 320 


Gly Thr Gly Lys Ala Glu Ile Val Leu Leu Asp His Gly Leu Tyr Gln 
                325                 330                 335     


Met Leu Thr Glu Glu Phe Arg Leu Asn Tyr Cys His Leu Trp Gln Ser 
            340                 345                 350         


Leu Ile Trp Thr Asp Met Lys Arg Val Lys Glu Tyr Ser Gln Arg Leu 
        355                 360                 365             


Gly Ala Gly Asp Leu Tyr Pro Leu Phe Ala Cys Met Leu Thr Ala Arg 
    370                 375                 380                 


Ser Trp Asp Ser Val Asn Arg Gly Ile Ser Gln Ala Pro Val Thr Ala 
385                 390                 395                 400 


Thr Glu Asp Leu Glu Ile Arg Asn Asn Ala Ala Asn Tyr Leu Pro Gln 
                405                 410                 415     


Ile Ser His Leu Leu Asn His Val Pro Arg Gln Met Leu Leu Ile Leu 
            420                 425                 430         


Lys Thr Asn Asp Leu Leu Arg Gly Ile Glu Ala Ala Leu Gly Thr Arg 
        435                 440                 445             


Ala Ser Ala Ser Ser Phe Leu Asn Met Ser Arg Cys Cys Ile Arg Ala 
    450                 455                 460                 


Leu Ala Glu His Lys Lys Lys Asn Thr Cys Ser Phe Phe Arg Arg Thr 
465                 470                 475                 480 


Gln Ile Ser Phe Ser Glu Ala Phe Asn Leu Trp Gln Ile Asn Leu His 
                485                 490                 495     


Glu Leu Ile Leu Arg Val Lys Gly Leu Lys Leu Ala Asp Arg Val Leu 
            500                 505                 510         


Ala Leu Ile Cys Trp Leu Phe Pro Ala Pro Leu 
        515                 520             


<210>  402
<211>  218
<212>  PRT
<213>  Homo Sapiens

<400>  402

Met Ala Arg Lys Ala Leu Lys Leu Ala Ser Trp Thr Ser Met Ala Leu 
1               5                   10                  15      


Ala Ala Ser Gly Ile Tyr Phe Tyr Ser Asn Lys Tyr Leu Asp Pro Asn 
            20                  25                  30          


Asp Phe Gly Ala Val Arg Val Gly Arg Ala Val Ala Thr Thr Ala Val 
        35                  40                  45              


Ile Ser Tyr Asp Tyr Leu Thr Ser Leu Lys Ser Val Pro Tyr Gly Ser 
    50                  55                  60                  


Glu Glu Tyr Leu Gln Leu Arg Ser Lys Val His Leu Arg Ser Ala Arg 
65                  70                  75                  80  


Arg Leu Cys Glu Leu Cys Cys Ala Asn Arg Gly Thr Phe Ile Lys Val 
                85                  90                  95      


Gly Gln His Leu Gly Ala Leu Asp Tyr Leu Leu Pro Glu Glu Tyr Thr 
            100                 105                 110         


Ser Thr Leu Lys Val Leu His Ser Gln Ala Pro Gln Ser Ser Met Gln 
        115                 120                 125             


Glu Ile Arg Gln Val Ile Arg Glu Asp Leu Gly Lys Glu Val Leu Val 
    130                 135                 140                 


Leu Ala Val Lys Gln Leu Phe Pro Glu Phe Glu Phe Met Trp Leu Val 
145                 150                 155                 160 


Asp Glu Ala Lys Lys Asn Leu Pro Leu Glu Leu Asp Phe Leu Asn Glu 
                165                 170                 175     


Gly Arg Asn Ala Glu Lys Val Ser Gln Met Leu Arg His Phe Asp Phe 
            180                 185                 190         


Leu Lys Pro Gly Gln Gln Ser Glu Thr Ala Ser Gln Gly Thr Thr Thr 
        195                 200                 205             


Thr Thr Lys Lys Lys Trp Asp Arg Lys Leu 
    210                 215             


<210>  403
<211>  176
<212>  PRT
<213>  Homo Sapiens

<400>  403

Met Thr Met Cys Ser Gly Ala Arg Leu Ala Leu Leu Val Tyr Gly Ile 
1               5                   10                  15      


Ile Met His Ser Ser Val Tyr Ser Ser Pro Ala Ala Ala Gly Leu Arg 
            20                  25                  30          


Phe Pro Gly Ile Arg Pro Glu Glu Glu Ala Tyr Gly Glu Asp Gly Asn 
        35                  40                  45              


Pro Leu Pro Asp Phe Asp Gly Ser Glu Pro Pro Gly Ala Gly Ser Pro 
    50                  55                  60                  


Ala Ser Ala Pro Arg Ala Ala Ala Ala Trp Tyr Arg Pro Ala Gly Arg 
65                  70                  75                  80  


Arg Asp Val Ala His Gly Ile Leu Asn Glu Ala Tyr Arg Lys Val Leu 
                85                  90                  95      


Asp Gln Leu Ser Ala Gly Lys His Leu Gln Ser Leu Val Ala Arg Gly 
            100                 105                 110         


Val Gly Gly Ser Leu Gly Gly Gly Ala Gly Asp Asp Ala Glu Pro Leu 
        115                 120                 125             


Ser Lys Arg His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr 
    130                 135                 140                 


Arg Lys Gln Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys 
145                 150                 155                 160 


Arg Tyr Lys Gln Arg Val Lys Asn Lys Gly Arg Arg Ile Ala Tyr Leu 
                165                 170                 175     


<210>  404
<211>  176
<212>  PRT
<213>  Homo Sapiens

<400>  404

Met Thr Met Cys Ser Gly Ala Arg Leu Ala Leu Leu Val Tyr Gly Ile 
1               5                   10                  15      


Ile Met His Ser Ser Val Tyr Ser Ser Pro Ala Ala Ala Gly Leu Arg 
            20                  25                  30          


Phe Pro Gly Ile Arg Pro Glu Glu Glu Ala Tyr Gly Glu Asp Gly Asn 
        35                  40                  45              


Pro Leu Pro Asp Phe Asp Gly Ser Glu Pro Pro Gly Ala Gly Ser Pro 
    50                  55                  60                  


Ala Ser Ala Pro Arg Ala Ala Ala Ala Trp Tyr Arg Pro Ala Gly Arg 
65                  70                  75                  80  


Arg Asp Val Ala His Gly Ile Leu Asn Glu Ala Tyr Arg Lys Val Leu 
                85                  90                  95      


Asp Gln Leu Ser Ala Gly Lys His Leu Gln Ser Leu Val Ala Arg Gly 
            100                 105                 110         


Val Gly Gly Ser Leu Gly Gly Gly Ala Gly Asp Asp Ala Glu Pro Leu 
        115                 120                 125             


Ser Lys Arg His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr 
    130                 135                 140                 


Arg Lys Gln Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys 
145                 150                 155                 160 


Arg Tyr Lys Gln Arg Val Lys Asn Lys Gly Arg Arg Ile Ala Tyr Leu 
                165                 170                 175     


<210>  405
<211>  74
<212>  PRT
<213>  Homo Sapiens

<400>  405

Met Ala Gly Val Val His Val Ser Leu Ala Ala Leu Leu Leu Leu Pro 
1               5                   10                  15      


Met Ala Pro Ala Met His Ser Asp Cys Ile Phe Lys Lys Glu Gln Ala 
            20                  25                  30          


Met Cys Leu Glu Lys Ile Gln Arg Ala Asn Glu Leu Met Gly Phe Asn 
        35                  40                  45              


Asp Ser Ser Pro Gly Cys Pro Gly Met Trp Asp Asn Ile Thr Cys Trp 
    50                  55                  60                  


Lys Pro Ala His Val Gly Glu Met Val Leu 
65                  70                  


<210>  406
<211>  447
<212>  PRT
<213>  Homo Sapiens

<400>  406

Met Ala Gly Val Val His Val Ser Leu Ala Ala Leu Leu Leu Leu Pro 
1               5                   10                  15      


Met Ala Pro Ala Met His Ser Asp Cys Ile Phe Lys Lys Glu Gln Ala 
            20                  25                  30          


Met Cys Leu Glu Lys Ile Gln Arg Ala Asn Glu Leu Met Gly Phe Asn 
        35                  40                  45              


Asp Ser Ser Pro Gly Cys Pro Gly Met Trp Asp Asn Ile Thr Cys Trp 
    50                  55                  60                  


Lys Pro Ala His Val Gly Glu Met Val Leu Val Ser Cys Pro Glu Leu 
65                  70                  75                  80  


Phe Arg Ile Phe Asn Pro Asp Gln Asp Met Gly Val Val Ser Arg Asn 
                85                  90                  95      


Cys Thr Glu Asp Gly Trp Ser Glu Pro Phe Pro His Tyr Phe Asp Ala 
            100                 105                 110         


Cys Gly Phe Asp Glu Tyr Glu Ser Glu Thr Gly Asp Gln Asp Tyr Tyr 
        115                 120                 125             


Tyr Leu Ser Val Lys Ala Leu Tyr Thr Val Gly Tyr Ser Thr Ser Leu 
    130                 135                 140                 


Val Thr Leu Thr Thr Ala Met Val Ile Leu Cys Arg Phe Arg Lys Leu 
145                 150                 155                 160 


His Cys Thr Arg Asn Phe Ile His Met Asn Leu Phe Val Ser Phe Met 
                165                 170                 175     


Leu Arg Ala Ile Ser Val Phe Ile Lys Asp Trp Ile Leu Tyr Ala Glu 
            180                 185                 190         


Gln Asp Ser Asn His Cys Phe Ile Ser Thr Val Glu Cys Lys Ala Val 
        195                 200                 205             


Met Val Phe Phe His Tyr Cys Val Val Ser Asn Tyr Phe Trp Leu Phe 
    210                 215                 220                 


Ile Glu Gly Leu Tyr Leu Phe Thr Leu Leu Val Glu Thr Phe Phe Pro 
225                 230                 235                 240 


Glu Arg Arg Tyr Phe Tyr Trp Tyr Thr Ile Ile Gly Trp Gly Thr Pro 
                245                 250                 255     


Thr Val Cys Val Thr Val Trp Ala Thr Leu Arg Leu Tyr Phe Asp Asp 
            260                 265                 270         


Thr Gly Cys Trp Asp Met Asn Asp Ser Thr Ala Leu Trp Trp Val Ile 
        275                 280                 285             


Lys Gly Pro Val Val Gly Ser Ile Met Val Asn Phe Val Leu Phe Ile 
    290                 295                 300                 


Gly Ile Ile Val Ile Leu Val Gln Lys Leu Gln Ser Pro Asp Met Gly 
305                 310                 315                 320 


Gly Asn Glu Ser Ser Ile Tyr Leu Arg Leu Ala Arg Ser Thr Leu Leu 
                325                 330                 335     


Leu Ile Pro Leu Phe Gly Ile His Tyr Thr Val Phe Ala Phe Ser Pro 
            340                 345                 350         


Glu Asn Val Ser Lys Arg Glu Arg Leu Val Phe Glu Leu Gly Leu Gly 
        355                 360                 365             


Ser Phe Gln Gly Phe Val Val Ala Val Leu Tyr Cys Phe Leu Asn Gly 
    370                 375                 380                 


Glu Val Gln Ala Glu Ile Lys Arg Lys Trp Arg Ser Trp Lys Val Asn 
385                 390                 395                 400 


Arg Tyr Phe Ala Val Asp Phe Lys His Arg His Pro Ser Leu Ala Ser 
                405                 410                 415     


Ser Gly Val Asn Gly Gly Thr Gln Leu Ser Ile Leu Ser Lys Ser Ser 
            420                 425                 430         


Ser Gln Ile Arg Met Ser Gly Leu Pro Ala Asp Asn Leu Ala Thr 
        435                 440                 445         


<210>  407
<211>  468
<212>  PRT
<213>  Homo Sapiens

<400>  407

Met Ala Gly Val Val His Val Ser Leu Ala Ala Leu Leu Leu Leu Pro 
1               5                   10                  15      


Met Ala Pro Ala Met His Ser Asp Cys Ile Phe Lys Lys Glu Gln Ala 
            20                  25                  30          


Met Cys Leu Glu Lys Ile Gln Arg Ala Asn Glu Leu Met Gly Phe Asn 
        35                  40                  45              


Asp Ser Ser Pro Gly Cys Pro Gly Met Trp Asp Asn Ile Thr Cys Trp 
    50                  55                  60                  


Lys Pro Ala His Val Gly Glu Met Val Leu Val Ser Cys Pro Glu Leu 
65                  70                  75                  80  


Phe Arg Ile Phe Asn Pro Asp Gln Val Trp Glu Thr Glu Thr Ile Gly 
                85                  90                  95      


Glu Ser Asp Phe Gly Asp Ser Asn Ser Leu Asp Leu Ser Asp Met Gly 
            100                 105                 110         


Val Val Ser Arg Asn Cys Thr Glu Asp Gly Trp Ser Glu Pro Phe Pro 
        115                 120                 125             


His Tyr Phe Asp Ala Cys Gly Phe Asp Glu Tyr Glu Ser Glu Thr Gly 
    130                 135                 140                 


Asp Gln Asp Tyr Tyr Tyr Leu Ser Val Lys Ala Leu Tyr Thr Val Gly 
145                 150                 155                 160 


Tyr Ser Thr Ser Leu Val Thr Leu Thr Thr Ala Met Val Ile Leu Cys 
                165                 170                 175     


Arg Phe Arg Lys Leu His Cys Thr Arg Asn Phe Ile His Met Asn Leu 
            180                 185                 190         


Phe Val Ser Phe Met Leu Arg Ala Ile Ser Val Phe Ile Lys Asp Trp 
        195                 200                 205             


Ile Leu Tyr Ala Glu Gln Asp Ser Asn His Cys Phe Ile Ser Thr Val 
    210                 215                 220                 


Glu Cys Lys Ala Val Met Val Phe Phe His Tyr Cys Val Val Ser Asn 
225                 230                 235                 240 


Tyr Phe Trp Leu Phe Ile Glu Gly Leu Tyr Leu Phe Thr Leu Leu Val 
                245                 250                 255     


Glu Thr Phe Phe Pro Glu Arg Arg Tyr Phe Tyr Trp Tyr Thr Ile Ile 
            260                 265                 270         


Gly Trp Gly Thr Pro Thr Val Cys Val Thr Val Trp Ala Thr Leu Arg 
        275                 280                 285             


Leu Tyr Phe Asp Asp Thr Gly Cys Trp Asp Met Asn Asp Ser Thr Ala 
    290                 295                 300                 


Leu Trp Trp Val Ile Lys Gly Pro Val Val Gly Ser Ile Met Val Asn 
305                 310                 315                 320 


Phe Val Leu Phe Ile Gly Ile Ile Val Ile Leu Val Gln Lys Leu Gln 
                325                 330                 335     


Ser Pro Asp Met Gly Gly Asn Glu Ser Ser Ile Tyr Leu Arg Leu Ala 
            340                 345                 350         


Arg Ser Thr Leu Leu Leu Ile Pro Leu Phe Gly Ile His Tyr Thr Val 
        355                 360                 365             


Phe Ala Phe Ser Pro Glu Asn Val Ser Lys Arg Glu Arg Leu Val Phe 
    370                 375                 380                 


Glu Leu Gly Leu Gly Ser Phe Gln Gly Phe Val Val Ala Val Leu Tyr 
385                 390                 395                 400 


Cys Phe Leu Asn Gly Glu Val Gln Ala Glu Ile Lys Arg Lys Trp Arg 
                405                 410                 415     


Ser Trp Lys Val Asn Arg Tyr Phe Ala Val Asp Phe Lys His Arg His 
            420                 425                 430         


Pro Ser Leu Ala Ser Ser Gly Val Asn Gly Gly Thr Gln Leu Ser Ile 
        435                 440                 445             


Leu Ser Lys Ser Ser Ser Gln Ile Arg Met Ser Gly Leu Pro Ala Asp 
    450                 455                 460                 


Asn Leu Ala Thr 
465             


<210>  408
<211>  524
<212>  PRT
<213>  Homo Sapiens

<400>  408

Met Ala Gly Val Val His Val Ser Leu Ala Ala Leu Leu Leu Leu Pro 
1               5                   10                  15      


Met Ala Pro Ala Met His Ser Asp Cys Ile Phe Lys Lys Glu Gln Ala 
            20                  25                  30          


Met Cys Leu Glu Lys Ile Gln Arg Ala Asn Glu Leu Met Gly Phe Asn 
        35                  40                  45              


Asp Ser Ser Pro Gly Cys Pro Gly Met Trp Asp Asn Ile Thr Cys Trp 
    50                  55                  60                  


Lys Pro Ala His Val Gly Glu Met Val Leu Val Ser Cys Pro Glu Leu 
65                  70                  75                  80  


Phe Arg Ile Phe Asn Pro Asp Gln Val Trp Glu Thr Glu Thr Ile Gly 
                85                  90                  95      


Glu Ser Asp Phe Gly Asp Ser Asn Ser Leu Asp Leu Ser Asp Met Gly 
            100                 105                 110         


Val Val Ser Arg Asn Cys Thr Glu Asp Gly Trp Ser Glu Pro Phe Pro 
        115                 120                 125             


His Tyr Phe Asp Ala Cys Gly Phe Asp Glu Tyr Glu Ser Glu Thr Gly 
    130                 135                 140                 


Asp Gln Asp Tyr Tyr Tyr Leu Ser Val Lys Ala Leu Tyr Thr Val Gly 
145                 150                 155                 160 


Tyr Ser Thr Ser Leu Val Thr Leu Thr Thr Ala Met Val Ile Leu Cys 
                165                 170                 175     


Arg Phe Arg Lys Leu His Cys Thr Arg Asn Phe Ile His Met Asn Leu 
            180                 185                 190         


Phe Val Ser Phe Met Leu Arg Ala Ile Ser Val Phe Ile Lys Asp Trp 
        195                 200                 205             


Ile Leu Tyr Ala Glu Gln Asp Ser Asn His Cys Phe Ile Ser Thr Val 
    210                 215                 220                 


Glu Cys Lys Ala Val Met Val Phe Phe His Tyr Cys Val Val Ser Asn 
225                 230                 235                 240 


Tyr Phe Trp Leu Phe Ile Glu Gly Leu Tyr Leu Phe Thr Leu Leu Val 
                245                 250                 255     


Glu Thr Phe Phe Pro Glu Arg Arg Tyr Phe Tyr Trp Tyr Thr Ile Ile 
            260                 265                 270         


Gly Trp Gly Thr Pro Thr Val Cys Val Thr Val Trp Ala Thr Leu Arg 
        275                 280                 285             


Leu Tyr Phe Asp Asp Thr Gly Cys Trp Asp Met Asn Asp Ser Thr Ala 
    290                 295                 300                 


Leu Trp Trp Val Ile Lys Gly Pro Val Val Gly Ser Ile Met Val Asn 
305                 310                 315                 320 


Phe Val Leu Phe Ile Gly Ile Ile Val Ile Leu Val Gln Lys Leu Gln 
                325                 330                 335     


Ser Pro Asp Met Gly Gly Asn Glu Ser Ser Ile Tyr Leu Thr Asn Leu 
            340                 345                 350         


Ser Pro Arg Val Pro Lys Lys Ala Arg Glu Asp Pro Leu Pro Val Pro 
        355                 360                 365             


Ser Asp Gln His Ser Leu Pro Phe Leu Ser Cys Val Gln Lys Cys Tyr 
    370                 375                 380                 


Cys Lys Pro Gln Arg Ala Gln Gln His Ser Cys Lys Met Ser Glu Leu 
385                 390                 395                 400 


Ser Thr Ile Thr Leu Arg Leu Ala Arg Ser Thr Leu Leu Leu Ile Pro 
                405                 410                 415     


Leu Phe Gly Ile His Tyr Thr Val Phe Ala Phe Ser Pro Glu Asn Val 
            420                 425                 430         


Ser Lys Arg Glu Arg Leu Val Phe Glu Leu Gly Leu Gly Ser Phe Gln 
        435                 440                 445             


Gly Phe Val Val Ala Val Leu Tyr Cys Phe Leu Asn Gly Glu Val Gln 
    450                 455                 460                 


Ala Glu Ile Lys Arg Lys Trp Arg Ser Trp Lys Val Asn Arg Tyr Phe 
465                 470                 475                 480 


Ala Val Asp Phe Lys His Arg His Pro Ser Leu Ala Ser Ser Gly Val 
                485                 490                 495     


Asn Gly Gly Thr Gln Leu Ser Ile Leu Ser Lys Ser Ser Ser Gln Ile 
            500                 505                 510         


Arg Met Ser Gly Leu Pro Ala Asp Asn Leu Ala Thr 
        515                 520                 


<210>  409
<211>  496
<212>  PRT
<213>  Homo Sapiens

<400>  409

Met Ala Gly Val Val His Val Ser Leu Ala Ala Leu Leu Leu Leu Pro 
1               5                   10                  15      


Met Ala Pro Ala Met His Ser Asp Cys Ile Phe Lys Lys Glu Gln Ala 
            20                  25                  30          


Met Cys Leu Glu Lys Ile Gln Arg Ala Asn Glu Leu Met Gly Phe Asn 
        35                  40                  45              


Asp Ser Ser Pro Gly Cys Pro Gly Met Trp Asp Asn Ile Thr Cys Trp 
    50                  55                  60                  


Lys Pro Ala His Val Gly Glu Met Val Leu Val Ser Cys Pro Glu Leu 
65                  70                  75                  80  


Phe Arg Ile Phe Asn Pro Asp Gln Val Trp Glu Thr Glu Thr Ile Gly 
                85                  90                  95      


Glu Ser Asp Phe Gly Asp Ser Asn Ser Leu Asp Leu Ser Asp Met Gly 
            100                 105                 110         


Val Val Ser Arg Asn Cys Thr Glu Asp Gly Trp Ser Glu Pro Phe Pro 
        115                 120                 125             


His Tyr Phe Asp Ala Cys Gly Phe Asp Glu Tyr Glu Ser Glu Thr Gly 
    130                 135                 140                 


Asp Gln Asp Tyr Tyr Tyr Leu Ser Val Lys Ala Leu Tyr Thr Val Gly 
145                 150                 155                 160 


Tyr Ser Thr Ser Leu Val Thr Leu Thr Thr Ala Met Val Ile Leu Cys 
                165                 170                 175     


Arg Phe Arg Lys Leu His Cys Thr Arg Asn Phe Ile His Met Asn Leu 
            180                 185                 190         


Phe Val Ser Phe Met Leu Arg Ala Ile Ser Val Phe Ile Lys Asp Trp 
        195                 200                 205             


Ile Leu Tyr Ala Glu Gln Asp Ser Asn His Cys Phe Ile Ser Thr Val 
    210                 215                 220                 


Glu Cys Lys Ala Val Met Val Phe Phe His Tyr Cys Val Val Ser Asn 
225                 230                 235                 240 


Tyr Phe Trp Leu Phe Ile Glu Gly Leu Tyr Leu Phe Thr Leu Leu Val 
                245                 250                 255     


Glu Thr Phe Phe Pro Glu Arg Arg Tyr Phe Tyr Trp Tyr Thr Ile Ile 
            260                 265                 270         


Gly Trp Gly Thr Pro Thr Val Cys Val Thr Val Trp Ala Thr Leu Arg 
        275                 280                 285             


Leu Tyr Phe Asp Asp Thr Gly Cys Trp Asp Met Asn Asp Ser Thr Ala 
    290                 295                 300                 


Leu Trp Trp Val Ile Lys Gly Pro Val Val Gly Ser Ile Met Val Asn 
305                 310                 315                 320 


Phe Val Leu Phe Ile Gly Ile Ile Val Ile Leu Val Gln Lys Leu Gln 
                325                 330                 335     


Ser Pro Asp Met Gly Gly Asn Glu Ser Ser Ile Tyr Phe Ser Cys Val 
            340                 345                 350         


Gln Lys Cys Tyr Cys Lys Pro Gln Arg Ala Gln Gln His Ser Cys Lys 
        355                 360                 365             


Met Ser Glu Leu Ser Thr Ile Thr Leu Arg Leu Ala Arg Ser Thr Leu 
    370                 375                 380                 


Leu Leu Ile Pro Leu Phe Gly Ile His Tyr Thr Val Phe Ala Phe Ser 
385                 390                 395                 400 


Pro Glu Asn Val Ser Lys Arg Glu Arg Leu Val Phe Glu Leu Gly Leu 
                405                 410                 415     


Gly Ser Phe Gln Gly Phe Val Val Ala Val Leu Tyr Cys Phe Leu Asn 
            420                 425                 430         


Gly Glu Val Gln Ala Glu Ile Lys Arg Lys Trp Arg Ser Trp Lys Val 
        435                 440                 445             


Asn Arg Tyr Phe Ala Val Asp Phe Lys His Arg His Pro Ser Leu Ala 
    450                 455                 460                 


Ser Ser Gly Val Asn Gly Gly Thr Gln Leu Ser Ile Leu Ser Lys Ser 
465                 470                 475                 480 


Ser Ser Gln Ile Arg Met Ser Gly Leu Pro Ala Asp Asn Leu Ala Thr 
                485                 490                 495     


<210>  410
<211>  496
<212>  PRT
<213>  Homo Sapiens

<400>  410

Met Ala Gly Val Val His Val Ser Leu Ala Ala Leu Leu Leu Leu Pro 
1               5                   10                  15      


Met Ala Pro Ala Met His Ser Asp Cys Ile Phe Lys Lys Glu Gln Ala 
            20                  25                  30          


Met Cys Leu Glu Lys Ile Gln Arg Ala Asn Glu Leu Met Gly Phe Asn 
        35                  40                  45              


Asp Ser Ser Pro Gly Cys Pro Gly Met Trp Asp Asn Ile Thr Cys Trp 
    50                  55                  60                  


Lys Pro Ala His Val Gly Glu Met Val Leu Val Ser Cys Pro Glu Leu 
65                  70                  75                  80  


Phe Arg Ile Phe Asn Pro Asp Gln Val Trp Glu Thr Glu Thr Ile Gly 
                85                  90                  95      


Glu Ser Asp Phe Gly Asp Ser Asn Ser Leu Asp Leu Ser Asp Met Gly 
            100                 105                 110         


Val Val Ser Arg Asn Cys Thr Glu Asp Gly Trp Ser Glu Pro Phe Pro 
        115                 120                 125             


His Tyr Phe Asp Ala Cys Gly Phe Asp Glu Tyr Glu Ser Glu Thr Gly 
    130                 135                 140                 


Asp Gln Asp Tyr Tyr Tyr Leu Ser Val Lys Ala Leu Tyr Thr Val Gly 
145                 150                 155                 160 


Tyr Ser Thr Ser Leu Val Thr Leu Thr Thr Ala Met Val Ile Leu Cys 
                165                 170                 175     


Arg Phe Arg Lys Leu His Cys Thr Arg Asn Phe Ile His Met Asn Leu 
            180                 185                 190         


Phe Val Ser Phe Met Leu Arg Ala Ile Ser Val Phe Ile Lys Asp Trp 
        195                 200                 205             


Ile Leu Tyr Ala Glu Gln Asp Ser Asn His Cys Phe Ile Ser Thr Val 
    210                 215                 220                 


Glu Cys Lys Ala Val Met Val Phe Phe His Tyr Cys Val Val Ser Asn 
225                 230                 235                 240 


Tyr Phe Trp Leu Phe Ile Glu Gly Leu Tyr Leu Phe Thr Leu Leu Val 
                245                 250                 255     


Glu Thr Phe Phe Pro Glu Arg Arg Tyr Phe Tyr Trp Tyr Thr Ile Ile 
            260                 265                 270         


Gly Trp Gly Thr Pro Thr Val Cys Val Thr Val Trp Ala Thr Leu Arg 
        275                 280                 285             


Leu Tyr Phe Asp Asp Thr Gly Cys Trp Asp Met Asn Asp Ser Thr Ala 
    290                 295                 300                 


Leu Trp Trp Val Ile Lys Gly Pro Val Val Gly Ser Ile Met Val Asn 
305                 310                 315                 320 


Phe Val Leu Phe Ile Gly Ile Ile Val Ile Leu Val Gln Lys Leu Gln 
                325                 330                 335     


Ser Pro Asp Met Gly Gly Asn Glu Ser Ser Ile Tyr Phe Ser Cys Val 
            340                 345                 350         


Gln Lys Cys Tyr Cys Lys Pro Gln Arg Ala Gln Gln His Ser Cys Lys 
        355                 360                 365             


Met Ser Glu Leu Ser Thr Ile Thr Leu Arg Leu Ala Arg Ser Thr Leu 
    370                 375                 380                 


Leu Leu Ile Pro Leu Phe Gly Ile His Tyr Thr Val Phe Ala Phe Ser 
385                 390                 395                 400 


Pro Glu Asn Val Ser Lys Arg Glu Arg Leu Val Phe Glu Leu Gly Leu 
                405                 410                 415     


Gly Ser Phe Gln Gly Phe Val Val Ala Val Leu Tyr Cys Phe Leu Asn 
            420                 425                 430         


Gly Glu Val Gln Ala Glu Ile Lys Arg Lys Trp Arg Ser Trp Lys Val 
        435                 440                 445             


Asn Arg Tyr Phe Ala Val Asp Phe Lys His Arg His Pro Ser Leu Ala 
    450                 455                 460                 


Ser Ser Gly Val Asn Gly Gly Thr Gln Leu Ser Ile Leu Ser Lys Ser 
465                 470                 475                 480 


Ser Ser Gln Ile Arg Met Ser Gly Leu Pro Ala Asp Asn Leu Ala Thr 
                485                 490                 495     


<210>  411
<211>  148
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  411

Xaa Ala Thr Leu Arg Leu Tyr Phe Asp Asp Thr Gly Cys Trp Asp Met 
1               5                   10                  15      


Asn Asp Ser Thr Ala Leu Trp Trp Val Ile Lys Gly Pro Val Val Gly 
            20                  25                  30          


Ser Ile Met Val Asn Phe Val Leu Phe Ile Gly Ile Ile Val Ile Leu 
        35                  40                  45              


Val Gln Lys Leu Gln Ser Pro Asp Met Gly Gly Asn Glu Ser Ser Ile 
    50                  55                  60                  


Tyr Leu Thr Asn Leu Ser Pro Arg Val Pro Lys Lys Ala Arg Glu Asp 
65                  70                  75                  80  


Pro Leu Pro Val Pro Ser Asp Gln His Ser Leu Pro Phe Leu Arg Leu 
                85                  90                  95      


Ala Arg Ser Thr Leu Leu Leu Ile Pro Leu Phe Gly Ile His Tyr Thr 
            100                 105                 110         


Val Phe Ala Phe Ser Pro Glu Asn Val Ser Lys Arg Glu Arg Leu Val 
        115                 120                 125             


Phe Glu Leu Gly Leu Gly Ser Phe Gln Gly Phe Val Val Ala Val Leu 
    130                 135                 140                 


Tyr Cys Phe Leu 
145             


<210>  412
<211>  97
<212>  PRT
<213>  Homo Sapiens

<400>  412

Met Ala Ser Tyr Ile Asp Gln Asp Met Gln Val Leu Trp Tyr Gln Asp 
1               5                   10                  15      


Gly Arg Ile Val Glu Thr Asp Glu Ser Gln Gly Ile Phe Val Glu Lys 
            20                  25                  30          


Asn Met Ile His Asn Cys Ser Leu Ile Ala Ser Ala Leu Thr Ile Ser 
        35                  40                  45              


Asn Ile Gln Ala Gly Ser Thr Gly Asn Trp Gly Cys His Val Gln Thr 
    50                  55                  60                  


Lys Arg Gly Asn Asn Thr Arg Thr Val Asp Ile Val Val Leu Glu Ser 
65                  70                  75                  80  


Ser Ala Gln Tyr Cys Pro Pro Glu Arg Val Val Asn Asn Lys Gly Asp 
                85                  90                  95      


Phe 
    


<210>  413
<211>  1321
<212>  PRT
<213>  Homo Sapiens

<400>  413

Met Glu Pro Pro Gly Arg Arg Arg Gly Arg Ala Gln Pro Pro Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ser Leu Leu Ala Leu Leu Ala Leu Leu Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Ala Ala Leu Pro Ala Gly Cys Lys His Asp Gly Arg 
        35                  40                  45              


Pro Arg Gly Ala Gly Arg Ala Ala Gly Ala Ala Glu Gly Lys Val Val 
    50                  55                  60                  


Cys Ser Ser Leu Glu Leu Ala Gln Val Leu Pro Pro Asp Thr Leu Pro 
65                  70                  75                  80  


Asn Arg Thr Val Thr Leu Ile Leu Ser Asn Asn Lys Ile Ser Glu Leu 
                85                  90                  95      


Lys Asn Gly Ser Phe Ser Gly Leu Ser Leu Leu Glu Arg Leu Asp Leu 
            100                 105                 110         


Arg Asn Asn Leu Ile Ser Ser Ile Asp Pro Gly Ala Phe Trp Gly Leu 
        115                 120                 125             


Ser Ser Leu Lys Arg Leu Asp Leu Thr Asn Asn Arg Ile Gly Cys Leu 
    130                 135                 140                 


Asn Ala Asp Ile Phe Arg Gly Leu Thr Asn Leu Val Arg Leu Asn Leu 
145                 150                 155                 160 


Ser Gly Asn Leu Phe Ser Ser Leu Ser Gln Gly Thr Phe Asp Tyr Leu 
                165                 170                 175     


Ala Ser Leu Arg Ser Leu Glu Phe Gln Thr Glu Tyr Leu Leu Cys Asp 
            180                 185                 190         


Cys Asn Ile Leu Trp Met His Arg Trp Val Lys Glu Lys Asn Ile Thr 
        195                 200                 205             


Val Arg Asp Thr Arg Cys Val Tyr Pro Lys Ser Leu Gln Ala Gln Pro 
    210                 215                 220                 


Val Thr Gly Val Lys Gln Glu Leu Leu Thr Cys Asp Pro Pro Leu Glu 
225                 230                 235                 240 


Leu Pro Ser Phe Tyr Met Thr Pro Ser His Arg Gln Val Val Phe Glu 
                245                 250                 255     


Gly Asp Ser Leu Pro Phe Gln Cys Met Ala Ser Tyr Ile Asp Gln Asp 
            260                 265                 270         


Met Gln Val Leu Trp Tyr Gln Asp Gly Arg Ile Val Glu Thr Asp Glu 
        275                 280                 285             


Ser Gln Gly Ile Phe Val Glu Lys Asn Met Ile His Asn Cys Ser Leu 
    290                 295                 300                 


Ile Ala Ser Ala Leu Thr Ile Ser Asn Ile Gln Ala Gly Ser Thr Gly 
305                 310                 315                 320 


Asn Trp Gly Cys His Val Gln Thr Lys Arg Gly Asn Asn Thr Arg Thr 
                325                 330                 335     


Val Asp Ile Val Val Leu Glu Ser Ser Ala Gln Tyr Cys Pro Pro Glu 
            340                 345                 350         


Arg Val Val Asn Asn Lys Gly Asp Phe Arg Trp Pro Arg Thr Leu Ala 
        355                 360                 365             


Gly Ile Thr Ala Tyr Leu Gln Cys Thr Arg Asn Thr His Gly Ser Gly 
    370                 375                 380                 


Ile Tyr Pro Gly Asn Pro Gln Asp Glu Arg Lys Ala Trp Arg Arg Cys 
385                 390                 395                 400 


Asp Arg Gly Gly Phe Trp Ala Asp Asp Asp Tyr Ser Arg Cys Gln Tyr 
                405                 410                 415     


Ala Asn Asp Val Thr Arg Val Leu Tyr Met Phe Asn Gln Met Pro Leu 
            420                 425                 430         


Asn Leu Thr Asn Ala Val Ala Thr Ala Arg Gln Leu Leu Ala Tyr Thr 
        435                 440                 445             


Val Glu Ala Ala Asn Phe Ser Asp Lys Met Asp Val Ile Phe Val Ala 
    450                 455                 460                 


Glu Met Ile Glu Lys Phe Gly Arg Phe Thr Lys Glu Glu Lys Ser Lys 
465                 470                 475                 480 


Glu Leu Gly Asp Val Met Val Asp Ile Ala Ser Asn Ile Met Leu Ala 
                485                 490                 495     


Asp Glu Arg Val Leu Trp Leu Ala Gln Arg Glu Ala Lys Ala Cys Ser 
            500                 505                 510         


Arg Ile Val Gln Cys Leu Gln Arg Ile Ala Thr Tyr Arg Leu Ala Gly 
        515                 520                 525             


Gly Ala His Val Tyr Ser Thr Tyr Ser Pro Asn Ile Ala Leu Glu Ala 
    530                 535                 540                 


Tyr Val Ile Lys Ser Thr Gly Phe Thr Gly Met Thr Cys Thr Val Phe 
545                 550                 555                 560 


Gln Lys Val Ala Ala Ser Asp Arg Thr Gly Leu Ser Asp Tyr Gly Arg 
                565                 570                 575     


Arg Asp Pro Glu Gly Asn Leu Asp Lys Gln Leu Ser Phe Lys Cys Asn 
            580                 585                 590         


Val Ser Asn Thr Phe Ser Ser Leu Ala Leu Lys Asn Thr Ile Val Glu 
        595                 600                 605             


Ala Ser Ile Gln Leu Pro Pro Ser Leu Phe Ser Pro Lys Gln Lys Arg 
    610                 615                 620                 


Glu Leu Arg Pro Thr Asp Asp Ser Leu Tyr Lys Leu Gln Leu Ile Ala 
625                 630                 635                 640 


Phe Arg Asn Gly Lys Leu Phe Pro Ala Thr Gly Asn Ser Thr Asn Leu 
                645                 650                 655     


Ala Asp Asp Gly Lys Arg Arg Thr Val Val Thr Pro Val Ile Leu Thr 
            660                 665                 670         


Lys Ile Asp Gly Val Asn Val Asp Thr His His Ile Pro Val Asn Val 
        675                 680                 685             


Thr Leu Arg Arg Ile Ala His Gly Ala Asp Ala Val Ala Ala Arg Trp 
    690                 695                 700                 


Asp Phe Asp Leu Leu Asn Gly Gln Gly Gly Trp Lys Ser Asp Gly Cys 
705                 710                 715                 720 


His Ile Leu Tyr Ser Asp Glu Asn Ile Thr Thr Ile Gln Cys Tyr Ser 
                725                 730                 735     


Leu Ser Asn Tyr Ala Val Leu Met Asp Leu Thr Gly Ser Glu Leu Tyr 
            740                 745                 750         


Thr Gln Ala Ala Ser Leu Leu His Pro Val Val Tyr Thr Thr Ala Ile 
        755                 760                 765             


Ile Leu Leu Leu Cys Leu Leu Ala Val Ile Val Ser Tyr Ile Tyr His 
    770                 775                 780                 


His Ser Leu Ile Arg Ile Ser Leu Lys Ser Trp His Met Leu Val Asn 
785                 790                 795                 800 


Leu Cys Phe His Ile Phe Leu Thr Cys Val Val Phe Val Gly Gly Ile 
                805                 810                 815     


Thr Gln Thr Arg Asn Ala Ser Ile Cys Gln Ala Val Gly Ile Ile Leu 
            820                 825                 830         


His Tyr Ser Thr Leu Ala Thr Val Leu Trp Val Gly Val Thr Ala Arg 
        835                 840                 845             


Asn Ile Tyr Lys Gln Val Thr Lys Lys Ala Lys Arg Cys Gln Asp Pro 
    850                 855                 860                 


Asp Glu Pro Pro Pro Pro Pro Arg Pro Met Leu Arg Phe Tyr Leu Ile 
865                 870                 875                 880 


Gly Gly Gly Ile Pro Ile Ile Val Cys Gly Ile Thr Ala Ala Ala Asn 
                885                 890                 895     


Ile Lys Asn Tyr Gly Ser Arg Pro Asn Ala Pro Tyr Cys Trp Met Ala 
            900                 905                 910         


Trp Glu Pro Ser Leu Gly Ala Phe Tyr Gly Pro Ala Ser Phe Ile Thr 
        915                 920                 925             


Phe Val Asn Cys Met Tyr Phe Leu Ser Ile Phe Ile Gln Leu Lys Arg 
    930                 935                 940                 


His Pro Glu Arg Lys Tyr Glu Leu Lys Glu Pro Thr Glu Glu Gln Gln 
945                 950                 955                 960 


Arg Leu Ala Ala Asn Glu Asn Gly Glu Ile Asn His Gln Asp Ser Met 
                965                 970                 975     


Ser Leu Ser Leu Ile Ser Thr Ser Ala Leu Glu Asn Glu His Thr Phe 
            980                 985                 990         


His Ser Gln Leu Leu Gly Ala Ser  Leu Thr Leu Leu Leu  Tyr Val Ala 
        995                 1000                 1005             


Leu Trp  Met Phe Gly Ala Leu  Ala Val Ser Leu Tyr  Tyr Pro Leu 
    1010                 1015                 1020             


Asp Leu  Val Phe Ser Phe Val  Phe Gly Ala Thr Ser  Leu Ser Phe 
    1025                 1030                 1035             


Ser Ala  Phe Phe Val Val His  His Cys Val Asn Arg  Glu Asp Val 
    1040                 1045                 1050             


Arg Leu  Ala Trp Ile Met Thr  Cys Cys Pro Gly Arg  Ser Ser Tyr 
    1055                 1060                 1065             


Ser Val  Gln Val Asn Val Gln  Pro Pro Asn Ser Asn  Gly Thr Asn 
    1070                 1075                 1080             


Gly Glu  Ala Pro Lys Cys Pro  Asn Ser Ser Ala Glu  Ser Ser Cys 
    1085                 1090                 1095             


Thr Asn  Lys Ser Ala Ser Ser  Phe Lys Asn Ser Ser  Gln Gly Cys 
    1100                 1105                 1110             


Lys Leu  Thr Asn Leu Gln Ala  Ala Ala Ala Gln Cys  His Ala Asn 
    1115                 1120                 1125             


Ser Leu  Pro Leu Asn Ser Thr  Pro Gln Leu Asp Asn  Ser Leu Thr 
    1130                 1135                 1140             


Glu His  Ser Met Asp Asn Asp  Ile Lys Met His Val  Ala Pro Leu 
    1145                 1150                 1155             


Glu Val  Gln Phe Arg Thr Asn  Val His Ser Ser Arg  His His Lys 
    1160                 1165                 1170             


Asn Arg  Ser Lys Gly His Arg  Ala Ser Arg Leu Thr  Val Leu Arg 
    1175                 1180                 1185             


Glu Tyr  Ala Tyr Asp Val Pro  Thr Ser Val Glu Gly  Ser Val Gln 
    1190                 1195                 1200             


Asn Gly  Leu Pro Lys Ser Arg  Leu Gly Asn Asn Glu  Gly His Ser 
    1205                 1210                 1215             


Arg Ser  Arg Arg Ala Tyr Leu  Ala Tyr Arg Glu Arg  Gln Tyr Asn 
    1220                 1225                 1230             


Pro Pro  Gln Gln Asp Ser Ser  Asp Ala Cys Ser Thr  Leu Pro Lys 
    1235                 1240                 1245             


Ser Ser  Arg Asn Phe Glu Lys  Pro Val Ser Thr Thr  Ser Lys Lys 
    1250                 1255                 1260             


Asp Ala  Leu Arg Lys Pro Ala  Val Val Glu Leu Glu  Asn Gln Gln 
    1265                 1270                 1275             


Lys Ser  Tyr Gly Leu Asn Leu  Ala Ile Gln Asn Gly  Pro Ile Lys 
    1280                 1285                 1290             


Ser Asn  Gly Gln Glu Gly Pro  Leu Leu Gly Thr Asp  Ser Thr Gly 
    1295                 1300                 1305             


Asn Val  Arg Thr Gly Leu Trp  Lys His Glu Thr Thr  Val 
    1310                 1315                 1320     


<210>  414
<211>  616
<212>  PRT
<213>  Homo Sapiens

<400>  414

Met Glu Pro Pro Gly Arg Arg Arg Gly Arg Ala Gln Pro Pro Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ser Leu Leu Ala Leu Leu Ala Leu Leu Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Ala Ala Leu Pro Ala Gly Cys Lys His Asp Gly Arg 
        35                  40                  45              


Pro Arg Gly Ala Gly Arg Ala Ala Gly Ala Ala Glu Gly Lys Val Val 
    50                  55                  60                  


Cys Ser Ser Leu Glu Leu Ala Gln Val Leu Pro Pro Asp Thr Leu Pro 
65                  70                  75                  80  


Asn Arg Thr Val Thr Leu Ile Leu Ser Asn Asn Lys Ile Ser Glu Leu 
                85                  90                  95      


Lys Asn Gly Ser Phe Ser Gly Leu Ser Leu Leu Glu Arg Leu Asp Leu 
            100                 105                 110         


Arg Asn Asn Leu Ile Ser Ser Ile Asp Pro Gly Ala Phe Trp Gly Leu 
        115                 120                 125             


Ser Ser Leu Lys Arg Leu Asp Leu Thr Asn Asn Arg Ile Gly Cys Leu 
    130                 135                 140                 


Asn Ala Asp Ile Phe Arg Gly Leu Thr Asn Leu Val Arg Leu Asn Leu 
145                 150                 155                 160 


Ser Gly Asn Leu Phe Ser Ser Leu Ser Gln Gly Thr Phe Asp Tyr Leu 
                165                 170                 175     


Ala Ser Leu Arg Ser Leu Glu Phe Gln Thr Glu Tyr Leu Leu Cys Asp 
            180                 185                 190         


Cys Asn Ile Leu Trp Met His Arg Trp Val Lys Glu Lys Asn Ile Thr 
        195                 200                 205             


Val Arg Asp Thr Arg Cys Val Tyr Pro Lys Ser Leu Gln Ala Gln Pro 
    210                 215                 220                 


Val Thr Gly Val Lys Gln Glu Leu Leu Thr Cys Asp Pro Pro Leu Glu 
225                 230                 235                 240 


Leu Pro Ser Phe Tyr Met Thr Pro Ser His Arg Gln Val Val Phe Glu 
                245                 250                 255     


Gly Asp Ser Leu Pro Phe Gln Cys Met Ala Ser Tyr Ile Asp Gln Asp 
            260                 265                 270         


Met Gln Val Leu Trp Tyr Gln Asp Gly Arg Ile Val Glu Thr Asp Glu 
        275                 280                 285             


Ser Gln Gly Ile Phe Val Glu Lys Asn Met Ile His Asn Cys Ser Leu 
    290                 295                 300                 


Ile Ala Ser Ala Leu Thr Ile Ser Asn Ile Gln Ala Gly Ser Thr Gly 
305                 310                 315                 320 


Asn Trp Gly Cys His Val Gln Thr Lys Arg Gly Asn Asn Thr Arg Thr 
                325                 330                 335     


Val Asp Ile Val Val Leu Glu Ser Ser Ala Gln Tyr Cys Pro Pro Glu 
            340                 345                 350         


Arg Val Val Asn Asn Lys Gly Asp Phe Arg Trp Pro Arg Thr Leu Ala 
        355                 360                 365             


Gly Ile Thr Ala Tyr Leu Gln Cys Thr Arg Asn Thr His Gly Ser Gly 
    370                 375                 380                 


Ile Tyr Pro Gly Asn Pro Gln Asp Glu Arg Lys Ala Trp Arg Arg Cys 
385                 390                 395                 400 


Asp Arg Gly Gly Phe Trp Ala Asp Asp Asp Tyr Ser Arg Cys Gln Tyr 
                405                 410                 415     


Ala Asn Asp Val Thr Arg Val Leu Tyr Met Phe Asn Gln Met Pro Leu 
            420                 425                 430         


Asn Leu Thr Asn Ala Val Ala Thr Ala Arg Gln Leu Leu Ala Tyr Thr 
        435                 440                 445             


Val Glu Ala Ala Asn Phe Ser Asp Lys Met Asp Val Ile Phe Val Ala 
    450                 455                 460                 


Glu Met Ile Glu Lys Phe Gly Arg Phe Thr Lys Glu Glu Lys Ser Lys 
465                 470                 475                 480 


Glu Leu Gly Asp Val Met Val Asp Ile Ala Ser Asn Ile Met Leu Ala 
                485                 490                 495     


Asp Glu Arg Val Leu Trp Leu Ala Gln Arg Glu Ala Lys Ala Cys Ser 
            500                 505                 510         


Arg Ile Val Gln Cys Leu Gln Arg Ile Ala Thr Tyr Arg Leu Ala Gly 
        515                 520                 525             


Gly Ala His Val Tyr Ser Thr Tyr Ser Pro Asn Ile Ala Leu Glu Ala 
    530                 535                 540                 


Tyr Val Ile Lys Ser Thr Gly Phe Thr Gly Met Thr Cys Thr Val Phe 
545                 550                 555                 560 


Gln Lys Val Ala Ala Ser Asp Arg Thr Gly Leu Ser Asp Tyr Gly Arg 
                565                 570                 575     


Arg Asp Pro Glu Gly Asn Leu Asp Lys Gln Leu Ser Phe Lys Cys Asn 
            580                 585                 590         


Val Ser Asn Thr Phe Ser Ser Leu Ala Leu Lys Val Cys Tyr Ile Leu 
        595                 600                 605             


Gln Ser Phe Lys Thr Ile Tyr Ser 
    610                 615     


<210>  415
<211>  34
<212>  PRT
<213>  Homo Sapiens

<400>  415

Met Leu Arg Phe Tyr Leu Ile Gly Gly Gly Ile Pro Ile Ile Val Cys 
1               5                   10                  15      


Gly Ile Thr Ala Ala Ala Asn Ile Lys Asn Tyr Gly Ser Arg Pro Asn 
            20                  25                  30          


Ala Pro 
        


<210>  416
<211>  381
<212>  PRT
<213>  Homo Sapiens

<400>  416

Met Pro Leu Lys Arg Asn Asn Ser Lys Tyr Pro Pro Leu Glu Leu Pro 
1               5                   10                  15      


Ser Phe Tyr Met Thr Pro Ser His Arg Gln Val Val Phe Glu Gly Asp 
            20                  25                  30          


Ser Leu Pro Phe Gln Cys Met Ala Ser Tyr Ile Asp Gln Asp Met Gln 
        35                  40                  45              


Val Leu Trp Tyr Gln Asp Gly Arg Ile Val Glu Thr Asp Glu Ser Gln 
    50                  55                  60                  


Gly Ile Phe Val Glu Lys Asn Met Ile His Asn Cys Ser Leu Ile Ala 
65                  70                  75                  80  


Ser Ala Leu Thr Ile Ser Asn Ile Gln Ala Gly Ser Thr Gly Asn Trp 
                85                  90                  95      


Gly Cys His Val Gln Thr Lys Arg Gly Asn Asn Thr Arg Thr Val Asp 
            100                 105                 110         


Ile Val Val Leu Glu Ser Ser Ala Gln Tyr Cys Pro Pro Glu Arg Val 
        115                 120                 125             


Val Asn Asn Lys Gly Asp Phe Arg Trp Pro Arg Thr Leu Ala Gly Ile 
    130                 135                 140                 


Thr Ala Tyr Leu Gln Cys Thr Arg Asn Thr His Gly Ser Gly Ile Tyr 
145                 150                 155                 160 


Pro Gly Asn Pro Gln Asp Glu Arg Lys Ala Trp Arg Arg Cys Asp Arg 
                165                 170                 175     


Gly Gly Phe Trp Ala Asp Asp Asp Tyr Ser Arg Cys Gln Tyr Ala Asn 
            180                 185                 190         


Asp Val Thr Arg Val Leu Tyr Met Phe Asn Gln Met Pro Leu Asn Leu 
        195                 200                 205             


Thr Asn Ala Val Ala Thr Ala Arg Gln Leu Leu Ala Tyr Thr Val Glu 
    210                 215                 220                 


Ala Ala Asn Phe Ser Asp Lys Met Asp Val Ile Phe Val Ala Glu Met 
225                 230                 235                 240 


Ile Glu Lys Phe Gly Arg Phe Thr Lys Glu Glu Lys Ser Lys Glu Leu 
                245                 250                 255     


Gly Asp Val Met Val Asp Ile Ala Ser Asn Ile Met Leu Ala Asp Glu 
            260                 265                 270         


Arg Val Leu Trp Leu Ala Gln Arg Glu Ala Lys Ala Cys Ser Arg Ile 
        275                 280                 285             


Val Gln Cys Leu Gln Arg Ile Ala Thr Tyr Arg Leu Ala Gly Gly Ala 
    290                 295                 300                 


His Val Tyr Ser Thr Tyr Ser Pro Asn Ile Ala Leu Glu Ala Tyr Val 
305                 310                 315                 320 


Ile Lys Ser Thr Gly Phe Thr Gly Met Thr Cys Thr Val Phe Gln Lys 
                325                 330                 335     


Val Ala Ala Ser Asp Arg Thr Gly Leu Ser Asp Tyr Gly Arg Arg Asp 
            340                 345                 350         


Pro Glu Gly Asn Leu Asp Lys Gln Leu Ser Phe Lys Cys Asn Val Ser 
        355                 360                 365             


Asn Thr Phe Ser Ser Leu Ala Leu Lys Gly Lys Phe Arg 
    370                 375                 380     


<210>  417
<211>  847
<212>  PRT
<213>  Homo Sapiens

<400>  417

Gly Lys Gly His Arg Met Thr Pro Ala Cys Pro Leu Leu Leu Ser Val 
1               5                   10                  15      


Ile Leu Ser Leu Arg Leu Ala Thr Ala Phe Asp Pro Ala Pro Ser Ala 
            20                  25                  30          


Cys Ser Ala Leu Ala Ser Gly Val Leu Tyr Gly Ala Phe Ser Leu Gln 
        35                  40                  45              


Asp Leu Phe Pro Thr Ile Ala Ser Gly Cys Ser Trp Thr Leu Glu Asn 
    50                  55                  60                  


Pro Asp Pro Thr Lys Tyr Ser Leu Tyr Leu Arg Phe Asn Arg Gln Glu 
65                  70                  75                  80  


Gln Val Cys Ala His Phe Ala Pro Arg Leu Leu Pro Leu Asp His Tyr 
                85                  90                  95      


Leu Val Asn Phe Thr Cys Leu Arg Pro Ser Pro Glu Glu Ala Val Ala 
            100                 105                 110         


Gln Ala Glu Ser Glu Val Gly Arg Pro Glu Glu Glu Glu Ala Glu Ala 
        115                 120                 125             


Ala Ala Gly Leu Glu Leu Cys Ser Gly Ser Gly Pro Phe Thr Phe Leu 
    130                 135                 140                 


His Phe Asp Lys Asn Phe Val Gln Leu Cys Leu Ser Ala Glu Pro Ser 
145                 150                 155                 160 


Glu Ala Pro Arg Leu Leu Ala Pro Ala Ala Leu Ala Phe Arg Phe Val 
                165                 170                 175     


Glu Val Leu Leu Ile Asn Asn Asn Asn Ser Ser Gln Phe Thr Cys Gly 
            180                 185                 190         


Val Leu Cys Arg Trp Ser Glu Glu Cys Gly Arg Ala Ala Gly Arg Ala 
        195                 200                 205             


Cys Gly Phe Ala Gln Pro Gly Cys Ser Cys Pro Gly Glu Ala Gly Ala 
    210                 215                 220                 


Gly Ser Thr Thr Thr Thr Ser Pro Gly Pro Pro Ala Ala His Thr Leu 
225                 230                 235                 240 


Ser Asn Ala Leu Val Pro Gly Gly Pro Ala Pro Pro Ala Glu Ala Asp 
                245                 250                 255     


Leu His Ser Gly Ser Ser Asn Asp Leu Phe Thr Thr Glu Met Arg Tyr 
            260                 265                 270         


Gly Glu Glu Pro Glu Glu Glu Pro Lys Val Lys Thr Gln Trp Pro Arg 
        275                 280                 285             


Ser Ala Asp Glu Pro Gly Leu Tyr Met Ala Gln Thr Gly Asp Pro Ala 
    290                 295                 300                 


Ala Glu Glu Trp Ser Pro Trp Ser Val Cys Ser Leu Thr Cys Gly Gln 
305                 310                 315                 320 


Gly Leu Gln Val Arg Thr Arg Ser Cys Val Ser Ser Pro Tyr Gly Thr 
                325                 330                 335     


Leu Cys Ser Gly Pro Leu Arg Glu Thr Arg Pro Cys Asn Asn Ser Ala 
            340                 345                 350         


Thr Cys Pro Val Glu Gly Gln Trp Leu Glu Trp Gly Pro Trp Gly Pro 
        355                 360                 365             


Cys Ser Thr Ser Cys Ala Asn Gly Thr Gln Gln Arg Ser Arg Lys Cys 
    370                 375                 380                 


Ser Val Ala Gly Pro Ala Trp Ala Thr Cys Thr Gly Ala Leu Thr Asp 
385                 390                 395                 400 


Thr Arg Glu Cys Ser Asn Leu Glu Cys Pro Ala Thr Asp Ser Lys Trp 
                405                 410                 415     


Gly Pro Trp Asn Ala Trp Ser Leu Cys Ser Lys Thr Cys Asp Thr Gly 
            420                 425                 430         


Trp Gln Arg Arg Phe Arg Met Cys Gln Ala Thr Gly Thr Gln Gly Tyr 
        435                 440                 445             


Pro Cys Glu Gly Thr Gly Glu Glu Val Lys Pro Cys Ser Glu Lys Arg 
    450                 455                 460                 


Cys Pro Ala Phe His Glu Met Cys Arg Asp Glu Tyr Val Met Leu Met 
465                 470                 475                 480 


Thr Trp Lys Lys Ala Ala Ala Gly Glu Ile Ile Tyr Asn Lys Cys Pro 
                485                 490                 495     


Pro Asn Ala Ser Gly Ser Ala Ser Arg Arg Cys Leu Leu Ser Ala Gln 
            500                 505                 510         


Gly Val Ala Tyr Trp Gly Leu Pro Ser Phe Ala Arg Cys Ile Ser His 
        515                 520                 525             


Glu Tyr Arg Tyr Leu Tyr Leu Ser Leu Arg Glu His Leu Ala Lys Gly 
    530                 535                 540                 


Gln Arg Met Leu Ala Gly Glu Gly Met Ser Gln Val Val Arg Ser Leu 
545                 550                 555                 560 


Gln Glu Leu Leu Ala Arg Arg Thr Tyr Tyr Ser Gly Asp Leu Leu Phe 
                565                 570                 575     


Ser Val Asp Ile Leu Arg Asn Val Thr Asp Thr Phe Lys Arg Ala Thr 
            580                 585                 590         


Tyr Val Pro Ser Ala Asp Asp Val Gln Arg Phe Phe Gln Val Val Ser 
        595                 600                 605             


Phe Met Val Asp Ala Glu Asn Lys Glu Lys Trp Asp Asp Ala Gln Gln 
    610                 615                 620                 


Val Ser Pro Gly Ser Val His Leu Leu Arg Val Val Glu Asp Phe Ile 
625                 630                 635                 640 


His Leu Val Gly Asp Ala Leu Lys Ala Phe Gln Ser Ser Leu Ile Val 
                645                 650                 655     


Thr Asp Asn Leu Val Ile Ser Ile Gln Arg Glu Pro Val Ser Ala Val 
            660                 665                 670         


Ser Ser Asp Ile Thr Phe Pro Met Arg Gly Arg Arg Gly Met Lys Asp 
        675                 680                 685             


Trp Val Arg His Ser Glu Asp Arg Leu Phe Leu Pro Lys Glu Val Leu 
    690                 695                 700                 


Ser Leu Ser Ser Pro Gly Lys Pro Ala Thr Ser Gly Ala Ala Gly Ser 
705                 710                 715                 720 


Pro Gly Arg Gly Arg Gly Pro Gly Thr Val Pro Pro Gly Pro Gly His 
                725                 730                 735     


Ser His Gln Arg Leu Leu Pro Ala Asp Pro Asp Glu Ser Ser Tyr Phe 
            740                 745                 750         


Val Ile Gly Ala Val Leu Tyr Arg Thr Leu Gly Leu Ile Leu Pro Pro 
        755                 760                 765             


Pro Arg Pro Pro Leu Ala Val Thr Ser Arg Val Met Thr Val Thr Val 
    770                 775                 780                 


Arg Pro Pro Thr Gln Pro Pro Ala Glu Pro Leu Ile Thr Val Glu Leu 
785                 790                 795                 800 


Ser Tyr Ile Ile Asn Gly Thr Thr Asp Pro His Cys Ala Ser Trp Asp 
                805                 810                 815     


Tyr Ser Arg Ala Asp Ala Ser Ser Gly Asp Trp Asp Thr Glu Asn Cys 
            820                 825                 830         


Gln Thr Leu Glu Thr Gln Ala Ala His Thr Arg Cys Gln Cys Gln 
        835                 840                 845         


<210>  418
<211>  1585
<212>  PRT
<213>  Homo Sapiens

<400>  418

Met Glu Asn Thr Gly Trp Met Gly Lys Gly His Arg Met Thr Pro Ala 
1               5                   10                  15      


Cys Pro Leu Leu Leu Ser Val Ile Leu Ser Leu Arg Leu Ala Thr Ala 
            20                  25                  30          


Phe Asp Pro Ala Pro Ser Ala Cys Ser Ala Leu Ala Ser Gly Val Leu 
        35                  40                  45              


Tyr Gly Ala Phe Ser Leu Gln Asp Leu Phe Pro Thr Ile Ala Ser Gly 
    50                  55                  60                  


Cys Ser Trp Thr Leu Glu Asn Pro Asp Pro Thr Lys Tyr Ser Leu Tyr 
65                  70                  75                  80  


Leu Arg Phe Asn Arg Gln Glu Gln Val Cys Ala His Phe Ala Pro Arg 
                85                  90                  95      


Leu Leu Pro Leu Asp His Tyr Leu Val Asn Phe Thr Cys Leu Arg Pro 
            100                 105                 110         


Ser Pro Glu Glu Ala Val Ala Gln Ala Glu Ser Glu Val Gly Arg Pro 
        115                 120                 125             


Glu Glu Glu Glu Ala Glu Ala Ala Ala Gly Leu Glu Leu Cys Ser Gly 
    130                 135                 140                 


Ser Gly Pro Phe Thr Phe Leu His Phe Asp Lys Asn Phe Val Gln Leu 
145                 150                 155                 160 


Cys Leu Ser Ala Glu Pro Ser Glu Ala Pro Arg Leu Leu Ala Pro Ala 
                165                 170                 175     


Ala Leu Ala Phe Arg Phe Val Glu Val Leu Leu Ile Asn Asn Asn Asn 
            180                 185                 190         


Ser Ser Gln Phe Thr Cys Gly Val Leu Cys Arg Trp Ser Glu Glu Cys 
        195                 200                 205             


Gly Arg Ala Ala Gly Arg Ala Cys Gly Phe Ala Gln Pro Gly Cys Ser 
    210                 215                 220                 


Cys Pro Gly Glu Ala Gly Ala Gly Ser Thr Thr Thr Thr Ser Pro Gly 
225                 230                 235                 240 


Pro Pro Ala Ala His Thr Leu Ser Asn Ala Leu Val Pro Gly Gly Pro 
                245                 250                 255     


Ala Pro Pro Ala Glu Ala Asp Leu His Ser Gly Ser Ser Asn Asp Leu 
            260                 265                 270         


Phe Thr Thr Glu Met Arg Tyr Gly Glu Glu Pro Glu Glu Glu Pro Lys 
        275                 280                 285             


Val Lys Thr Gln Trp Pro Arg Ser Ala Asp Glu Pro Gly Leu Tyr Met 
    290                 295                 300                 


Ala Gln Thr Gly Asp Pro Ala Ala Glu Glu Trp Ser Pro Trp Ser Val 
305                 310                 315                 320 


Cys Ser Leu Thr Cys Gly Gln Gly Leu Gln Val Arg Thr Arg Ser Cys 
                325                 330                 335     


Val Ser Ser Pro Tyr Gly Thr Leu Cys Ser Gly Pro Leu Arg Glu Thr 
            340                 345                 350         


Arg Pro Cys Asn Asn Ser Ala Thr Cys Pro Val His Gly Val Trp Glu 
        355                 360                 365             


Glu Trp Gly Ser Trp Ser Leu Cys Ser Arg Ser Cys Gly Arg Gly Ser 
    370                 375                 380                 


Arg Ser Arg Met Arg Thr Cys Val Pro Pro Gln His Gly Gly Lys Ala 
385                 390                 395                 400 


Cys Glu Gly Pro Glu Leu Gln Thr Lys Leu Cys Ser Met Ala Ala Cys 
                405                 410                 415     


Pro Val Glu Gly Gln Trp Leu Glu Trp Gly Pro Trp Gly Pro Cys Ser 
            420                 425                 430         


Thr Ser Cys Ala Asn Gly Thr Gln Gln Arg Ser Arg Lys Cys Ser Val 
        435                 440                 445             


Ala Gly Pro Ala Trp Ala Thr Cys Thr Gly Ala Leu Thr Asp Thr Arg 
    450                 455                 460                 


Glu Cys Ser Asn Leu Glu Cys Pro Ala Thr Asp Ser Lys Trp Gly Pro 
465                 470                 475                 480 


Trp Asn Ala Trp Ser Leu Cys Ser Lys Thr Cys Asp Thr Gly Trp Gln 
                485                 490                 495     


Arg Arg Phe Arg Met Cys Gln Ala Thr Gly Thr Gln Gly Tyr Pro Cys 
            500                 505                 510         


Glu Gly Thr Gly Glu Glu Val Lys Pro Cys Ser Glu Lys Arg Cys Pro 
        515                 520                 525             


Ala Phe His Glu Met Cys Arg Asp Glu Tyr Val Met Leu Met Thr Trp 
    530                 535                 540                 


Lys Lys Ala Ala Ala Gly Glu Ile Ile Tyr Asn Lys Cys Pro Pro Asn 
545                 550                 555                 560 


Ala Ser Gly Ser Ala Ser Arg Arg Cys Leu Leu Ser Ala Gln Gly Val 
                565                 570                 575     


Ala Tyr Trp Gly Leu Pro Ser Phe Ala Arg Cys Ile Ser His Glu Tyr 
            580                 585                 590         


Arg Tyr Leu Tyr Leu Ser Leu Arg Glu His Leu Ala Lys Gly Gln Arg 
        595                 600                 605             


Met Leu Ala Gly Glu Gly Met Ser Gln Val Val Arg Ser Leu Gln Glu 
    610                 615                 620                 


Leu Leu Ala Arg Arg Thr Tyr Tyr Ser Gly Asp Leu Leu Phe Ser Val 
625                 630                 635                 640 


Asp Ile Leu Arg Asn Val Thr Asp Thr Phe Lys Arg Ala Thr Tyr Val 
                645                 650                 655     


Pro Ser Ala Asp Asp Val Gln Arg Phe Phe Gln Val Val Ser Phe Met 
            660                 665                 670         


Val Asp Ala Glu Asn Lys Glu Lys Trp Asp Asp Ala Gln Gln Val Ser 
        675                 680                 685             


Pro Gly Ser Val His Leu Leu Arg Val Val Glu Asp Phe Ile His Leu 
    690                 695                 700                 


Val Gly Asp Ala Leu Lys Ala Phe Gln Ser Ser Leu Ile Val Thr Asp 
705                 710                 715                 720 


Asn Leu Val Ile Ser Ile Gln Arg Glu Pro Val Ser Ala Val Ser Ser 
                725                 730                 735     


Asp Ile Thr Phe Pro Met Arg Gly Arg Arg Gly Met Lys Asp Trp Val 
            740                 745                 750         


Arg His Ser Glu Asp Arg Leu Phe Leu Pro Lys Glu Val Leu Ser Leu 
        755                 760                 765             


Ser Ser Pro Gly Lys Pro Ala Thr Ser Gly Ala Ala Gly Ser Pro Gly 
    770                 775                 780                 


Arg Gly Arg Gly Pro Gly Thr Val Pro Pro Gly Pro Gly His Ser His 
785                 790                 795                 800 


Gln Arg Leu Leu Pro Ala Asp Pro Asp Glu Ser Ser Tyr Phe Val Ile 
                805                 810                 815     


Gly Ala Val Leu Tyr Arg Thr Leu Gly Leu Ile Leu Pro Pro Pro Arg 
            820                 825                 830         


Pro Pro Leu Ala Val Thr Ser Arg Val Met Thr Val Thr Val Arg Pro 
        835                 840                 845             


Pro Thr Gln Pro Pro Ala Glu Pro Leu Ile Thr Val Glu Leu Ser Tyr 
    850                 855                 860                 


Ile Ile Asn Gly Thr Thr Asp Pro His Cys Ala Ser Trp Asp Tyr Ser 
865                 870                 875                 880 


Arg Ala Asp Ala Ser Ser Gly Asp Trp Asp Thr Glu Asn Cys Gln Thr 
                885                 890                 895     


Leu Glu Thr Gln Ala Ala His Thr Arg Cys Gln Cys Gln His Leu Ser 
            900                 905                 910         


Thr Phe Ala Val Leu Ala Gln Pro Pro Lys Asp Leu Thr Leu Glu Leu 
        915                 920                 925             


Ala Gly Ser Pro Ser Val Pro Leu Val Ile Gly Cys Ala Val Ser Cys 
    930                 935                 940                 


Met Ala Leu Leu Thr Leu Leu Ala Ile Tyr Ala Ala Phe Trp Arg Phe 
945                 950                 955                 960 


Ile Lys Ser Glu Arg Ser Ile Ile Leu Leu Asn Phe Cys Leu Ser Ile 
                965                 970                 975     


Leu Ala Ser Asn Ile Leu Ile Leu Val Gly Gln Ser Arg Val Leu Ser 
            980                 985                 990         


Lys Gly Val Cys Thr Met Thr Ala  Ala Phe Leu His Phe  Phe Phe Leu 
        995                 1000                 1005             


Ser Ser  Phe Cys Trp Val Leu  Thr Glu Ala Trp Gln  Ser Tyr Leu 
    1010                 1015                 1020             


Ala Val  Ile Gly Arg Met Arg  Thr Arg Leu Val Arg  Lys Arg Phe 
    1025                 1030                 1035             


Leu Cys  Leu Gly Trp Gly Leu  Pro Ala Leu Val Val  Ala Val Ser 
    1040                 1045                 1050             


Val Gly  Phe Thr Arg Thr Lys  Gly Tyr Gly Thr Ser  Ser Tyr Cys 
    1055                 1060                 1065             


Trp Leu  Ser Leu Glu Gly Gly  Leu Leu Tyr Ala Phe  Val Gly Pro 
    1070                 1075                 1080             


Ala Ala  Val Ile Val Leu Val  Asn Met Leu Ile Gly  Ile Ile Val 
    1085                 1090                 1095             


Phe Asn  Lys Leu Met Ala Arg  Asp Gly Ile Ser Asp  Lys Ser Lys 
    1100                 1105                 1110             


Lys Gln  Arg Ala Gly Ser Glu  Arg Cys Pro Trp Ala  Ser Leu Leu 
    1115                 1120                 1125             


Leu Pro  Cys Ser Ala Cys Gly  Ala Val Pro Ser Pro  Leu Leu Ser 
    1130                 1135                 1140             


Ser Ala  Ser Ala Arg Asn Ala  Met Ala Ser Leu Trp  Ser Ser Cys 
    1145                 1150                 1155             


Val Val  Leu Pro Leu Leu Ala  Leu Thr Trp Met Ser  Ala Val Leu 
    1160                 1165                 1170             


Ala Met  Thr Asp Arg Arg Ser  Val Leu Phe Gln Ala  Leu Phe Ala 
    1175                 1180                 1185             


Val Phe  Asn Ser Ala Gln Gly  Phe Val Ile Thr Ala  Val His Cys 
    1190                 1195                 1200             


Phe Leu  Arg Arg Glu Val Gln  Asp Val Val Lys Cys  Gln Met Gly 
    1205                 1210                 1215             


Val Cys  Arg Ala Asp Glu Ser  Glu Asp Ser Pro Asp  Ser Cys Lys 
    1220                 1225                 1230             


Asn Gly  Gln Leu Gln Ile Leu  Ser Asp Phe Glu Lys  Asp Val Asp 
    1235                 1240                 1245             


Leu Ala  Cys Gln Thr Val Leu  Phe Lys Glu Val Asn  Thr Cys Asn 
    1250                 1255                 1260             


Pro Ser  Thr Ile Thr Gly Thr  Leu Ser Arg Leu Ser  Leu Asp Glu 
    1265                 1270                 1275             


Asp Glu  Glu Pro Lys Ser Cys  Leu Val Gly Pro Glu  Gly Ser Leu 
    1280                 1285                 1290             


Ser Phe  Ser Pro Leu Pro Gly  Asn Ile Leu Val Pro  Met Ala Ala 
    1295                 1300                 1305             


Ser Pro  Gly Leu Gly Glu Pro  Pro Pro Pro Gln Glu  Ala Asn Pro 
    1310                 1315                 1320             


Val Tyr  Met Cys Gly Glu Gly  Gly Leu Arg Gln Leu  Asp Leu Thr 
    1325                 1330                 1335             


Trp Leu  Arg Pro Thr Glu Pro  Gly Ser Glu Gly Asp  Tyr Met Val 
    1340                 1345                 1350             


Leu Pro  Arg Arg Thr Leu Ser  Leu Gln Pro Gly Gly  Gly Gly Gly 
    1355                 1360                 1365             


Gly Gly  Glu Asp Ala Pro Arg  Ala Arg Pro Glu Gly  Thr Pro Arg 
    1370                 1375                 1380             


Arg Ala  Ala Lys Thr Val Ala  His Thr Glu Gly Tyr  Pro Ser Phe 
    1385                 1390                 1395             


Leu Ser  Val Asp His Ser Gly  Leu Gly Leu Gly Pro  Ala Tyr Gly 
    1400                 1405                 1410             


Ser Leu  Gln Asn Pro Tyr Gly  Met Thr Phe Gln Pro  Pro Pro Pro 
    1415                 1420                 1425             


Thr Pro  Ser Ala Arg Gln Val  Pro Glu Pro Gly Glu  Arg Ser Arg 
    1430                 1435                 1440             


Thr Met  Pro Arg Thr Val Pro  Gly Ser Thr Met Lys  Met Gly Ser 
    1445                 1450                 1455             


Leu Glu  Arg Lys Lys Leu Arg  Tyr Ser Asp Leu Asp  Phe Glu Lys 
    1460                 1465                 1470             


Val Met  His Thr Arg Lys Arg  His Ser Glu Leu Tyr  His Glu Leu 
    1475                 1480                 1485             


Asn Gln  Lys Phe His Thr Phe  Asp Arg Tyr Arg Ser  Gln Ser Thr 
    1490                 1495                 1500             


Ala Lys  Arg Glu Lys Arg Trp  Ser Val Ser Ser Gly  Gly Ala Ala 
    1505                 1510                 1515             


Glu Arg  Ser Val Cys Thr Asp  Lys Pro Ser Pro Gly  Glu Arg Pro 
    1520                 1525                 1530             


Ser Leu  Ser Gln His Arg Arg  His Gln Ser Trp Ser  Thr Phe Lys 
    1535                 1540                 1545             


Ser Met  Thr Leu Gly Ser Leu  Pro Pro Lys Pro Arg  Glu Arg Leu 
    1550                 1555                 1560             


Thr Leu  His Arg Ala Ala Ala  Trp Glu Pro Thr Glu  Pro Pro Asp 
    1565                 1570                 1575             


Gly Asp  Phe Gln Thr Glu Val  
    1580                 1585 


<210>  419
<211>  1584
<212>  PRT
<213>  Homo Sapiens

<400>  419

Met Glu Asn Thr Gly Trp Met Gly Lys Gly His Arg Met Thr Pro Ala 
1               5                   10                  15      


Cys Pro Leu Leu Leu Ser Val Ile Leu Ser Leu Arg Leu Ala Thr Ala 
            20                  25                  30          


Phe Asp Pro Ala Pro Ser Ala Cys Ser Ala Leu Ala Ser Gly Val Leu 
        35                  40                  45              


Tyr Gly Ala Phe Ser Leu Gln Asp Leu Phe Pro Thr Ile Ala Ser Gly 
    50                  55                  60                  


Cys Ser Trp Thr Leu Glu Asn Pro Asp Pro Thr Lys Tyr Ser Leu Tyr 
65                  70                  75                  80  


Leu Arg Phe Asn Arg Gln Glu Gln Val Cys Ala His Phe Ala Pro Arg 
                85                  90                  95      


Leu Leu Pro Leu Asp His Tyr Leu Val Asn Phe Thr Cys Leu Arg Pro 
            100                 105                 110         


Ser Pro Glu Glu Ala Val Ala Gln Ala Glu Ser Glu Val Gly Arg Pro 
        115                 120                 125             


Glu Glu Glu Glu Ala Glu Ala Ala Ala Gly Leu Glu Leu Cys Ser Gly 
    130                 135                 140                 


Ser Gly Pro Phe Thr Phe Leu His Phe Asp Lys Asn Phe Val Gln Leu 
145                 150                 155                 160 


Cys Leu Ser Ala Glu Pro Ser Glu Ala Pro Arg Leu Leu Ala Pro Ala 
                165                 170                 175     


Ala Leu Ala Phe Arg Phe Val Glu Val Leu Leu Ile Asn Asn Asn Asn 
            180                 185                 190         


Ser Ser Gln Phe Thr Cys Gly Val Leu Cys Arg Trp Ser Glu Glu Cys 
        195                 200                 205             


Gly Arg Ala Ala Gly Arg Ala Cys Gly Phe Ala Gln Pro Gly Cys Ser 
    210                 215                 220                 


Cys Pro Gly Glu Ala Gly Ala Gly Ser Thr Thr Thr Thr Ser Pro Gly 
225                 230                 235                 240 


Pro Pro Ala Ala His Thr Leu Ser Asn Ala Leu Val Pro Gly Gly Pro 
                245                 250                 255     


Ala Pro Pro Ala Glu Ala Asp Leu His Ser Gly Ser Ser Asn Asp Leu 
            260                 265                 270         


Phe Thr Thr Glu Met Arg Tyr Gly Glu Glu Pro Glu Glu Glu Pro Lys 
        275                 280                 285             


Val Lys Thr Gln Trp Pro Arg Ser Ala Asp Glu Pro Gly Leu Tyr Met 
    290                 295                 300                 


Ala Gln Thr Gly Asp Pro Ala Ala Glu Glu Trp Ser Pro Trp Ser Val 
305                 310                 315                 320 


Cys Ser Leu Thr Cys Gly Gln Gly Leu Gln Val Arg Thr Arg Ser Cys 
                325                 330                 335     


Val Ser Ser Pro Tyr Gly Thr Leu Cys Ser Gly Pro Leu Arg Glu Thr 
            340                 345                 350         


Arg Pro Cys Asn Asn Ser Ala Thr Cys Pro Val His Gly Val Trp Glu 
        355                 360                 365             


Glu Trp Gly Ser Trp Ser Leu Cys Ser Arg Ser Cys Gly Arg Gly Ser 
    370                 375                 380                 


Arg Ser Arg Met Arg Thr Cys Val Pro Pro Gln His Gly Gly Lys Ala 
385                 390                 395                 400 


Cys Glu Gly Pro Glu Leu Gln Thr Lys Leu Cys Ser Met Ala Ala Cys 
                405                 410                 415     


Pro Val Glu Gly Gln Trp Leu Glu Trp Gly Pro Trp Gly Pro Cys Ser 
            420                 425                 430         


Thr Ser Cys Ala Asn Gly Thr Gln Gln Arg Ser Arg Lys Cys Ser Val 
        435                 440                 445             


Ala Gly Pro Ala Trp Ala Thr Cys Thr Gly Ala Leu Thr Asp Thr Arg 
    450                 455                 460                 


Glu Cys Ser Asn Leu Glu Cys Pro Ala Thr Asp Ser Lys Trp Gly Pro 
465                 470                 475                 480 


Trp Asn Ala Trp Ser Leu Cys Ser Lys Thr Cys Asp Thr Gly Trp Gln 
                485                 490                 495     


Arg Arg Phe Arg Met Cys Gln Ala Thr Gly Thr Gln Gly Tyr Pro Cys 
            500                 505                 510         


Glu Gly Thr Gly Glu Glu Val Lys Pro Cys Ser Glu Lys Arg Cys Pro 
        515                 520                 525             


Ala Phe His Glu Met Cys Arg Asp Glu Tyr Val Met Leu Met Thr Trp 
    530                 535                 540                 


Lys Lys Ala Ala Ala Gly Glu Ile Ile Tyr Asn Lys Cys Pro Pro Asn 
545                 550                 555                 560 


Ala Ser Gly Ser Ala Ser Arg Arg Cys Leu Leu Ser Ala Gln Gly Val 
                565                 570                 575     


Ala Tyr Trp Gly Leu Pro Ser Phe Ala Arg Cys Ile Ser His Glu Tyr 
            580                 585                 590         


Arg Tyr Leu Tyr Leu Ser Leu Arg Glu His Leu Ala Lys Gly Gln Arg 
        595                 600                 605             


Met Leu Ala Gly Glu Gly Met Ser Gln Val Val Arg Ser Leu Gln Glu 
    610                 615                 620                 


Leu Leu Ala Arg Arg Thr Tyr Tyr Ser Gly Asp Leu Leu Phe Ser Val 
625                 630                 635                 640 


Asp Ile Leu Arg Asn Val Thr Asp Thr Phe Lys Arg Ala Thr Tyr Val 
                645                 650                 655     


Pro Ser Ala Asp Asp Val Gln Arg Phe Phe Gln Val Val Ser Phe Met 
            660                 665                 670         


Val Asp Ala Glu Asn Lys Glu Lys Trp Asp Asp Ala Gln Gln Val Ser 
        675                 680                 685             


Pro Gly Ser Val His Leu Leu Arg Val Val Glu Asp Phe Ile His Leu 
    690                 695                 700                 


Val Gly Asp Ala Leu Lys Ala Phe Gln Ser Ser Leu Ile Val Thr Asp 
705                 710                 715                 720 


Asn Leu Val Ile Ser Ile Gln Arg Glu Pro Val Ser Ala Val Ser Ser 
                725                 730                 735     


Asp Ile Thr Phe Pro Met Arg Gly Arg Arg Gly Met Lys Asp Trp Val 
            740                 745                 750         


Arg His Ser Glu Asp Arg Leu Phe Leu Pro Lys Glu Val Leu Ser Leu 
        755                 760                 765             


Ser Ser Pro Gly Lys Pro Ala Thr Ser Gly Ala Ala Gly Ser Pro Gly 
    770                 775                 780                 


Arg Gly Arg Gly Pro Gly Thr Val Pro Pro Gly Pro Gly His Ser His 
785                 790                 795                 800 


Gln Arg Leu Leu Pro Ala Asp Pro Asp Glu Ser Ser Tyr Phe Val Ile 
                805                 810                 815     


Gly Ala Val Leu Tyr Arg Thr Leu Gly Leu Ile Leu Pro Pro Pro Arg 
            820                 825                 830         


Pro Pro Leu Ala Val Thr Ser Arg Val Met Thr Val Thr Val Arg Pro 
        835                 840                 845             


Pro Thr Gln Pro Pro Ala Glu Pro Leu Ile Thr Val Glu Leu Ser Tyr 
    850                 855                 860                 


Ile Ile Asn Gly Thr Thr Asp Pro His Cys Ala Ser Trp Asp Tyr Ser 
865                 870                 875                 880 


Arg Ala Asp Ala Ser Ser Gly Asp Trp Asp Thr Glu Asn Cys Gln Thr 
                885                 890                 895     


Leu Glu Thr Gln Ala Ala His Thr Arg Cys Gln Cys Gln His Leu Ser 
            900                 905                 910         


Thr Phe Ala Val Leu Ala Gln Pro Pro Lys Asp Leu Thr Leu Glu Leu 
        915                 920                 925             


Ala Gly Ser Pro Ser Val Pro Leu Val Ile Gly Cys Ala Val Ser Cys 
    930                 935                 940                 


Met Ala Leu Leu Thr Leu Leu Ala Ile Tyr Ala Ala Phe Trp Arg Phe 
945                 950                 955                 960 


Ile Lys Ser Glu Arg Ser Ile Ile Leu Leu Asn Phe Cys Leu Ser Ile 
                965                 970                 975     


Leu Ala Ser Asn Ile Leu Ile Leu Val Gly Gln Ser Arg Val Leu Ser 
            980                 985                 990         


Lys Gly Val Cys Thr Met Thr Ala  Ala Phe Leu His Phe  Phe Phe Leu 
        995                 1000                 1005             


Ser Ser  Phe Cys Trp Val Leu  Thr Glu Ala Trp Gln  Ser Tyr Leu 
    1010                 1015                 1020             


Ala Val  Ile Gly Arg Met Arg  Thr Arg Leu Val Arg  Lys Arg Phe 
    1025                 1030                 1035             


Leu Cys  Leu Gly Trp Gly Leu  Pro Ala Leu Val Val  Ala Val Ser 
    1040                 1045                 1050             


Val Gly  Phe Thr Arg Thr Lys  Gly Tyr Gly Thr Ser  Ser Tyr Cys 
    1055                 1060                 1065             


Trp Leu  Ser Leu Glu Gly Gly  Leu Leu Tyr Ala Phe  Val Gly Pro 
    1070                 1075                 1080             


Ala Ala  Val Ile Val Leu Val  Asn Met Leu Ile Gly  Ile Ile Val 
    1085                 1090                 1095             


Phe Asn  Lys Leu Met Ala Arg  Asp Gly Ile Ser Asp  Lys Ser Lys 
    1100                 1105                 1110             


Lys Gln  Arg Ala Gly Ser Glu  Arg Cys Pro Trp Ala  Ser Leu Leu 
    1115                 1120                 1125             


Leu Pro  Cys Ser Ala Cys Gly  Ala Val Pro Ser Pro  Leu Leu Ser 
    1130                 1135                 1140             


Ser Ala  Ser Ala Arg Asn Ala  Met Ala Ser Leu Trp  Ser Ser Cys 
    1145                 1150                 1155             


Val Val  Leu Pro Leu Leu Ala  Leu Thr Trp Met Ser  Ala Val Leu 
    1160                 1165                 1170             


Ala Met  Thr Asp Arg Arg Ser  Val Leu Phe Gln Ala  Leu Phe Ala 
    1175                 1180                 1185             


Val Phe  Asn Ser Ala Gln Gly  Phe Val Ile Thr Ala  Val His Cys 
    1190                 1195                 1200             


Phe Leu  Arg Arg Glu Val Gln  Asp Val Val Lys Cys  Gln Met Gly 
    1205                 1210                 1215             


Val Cys  Arg Ala Asp Glu Ser  Glu Asp Ser Pro Asp  Ser Cys Lys 
    1220                 1225                 1230             


Asn Gly  Gln Leu Gln Ile Leu  Ser Asp Phe Glu Lys  Asp Val Asp 
    1235                 1240                 1245             


Leu Ala  Cys Gln Thr Val Leu  Phe Lys Glu Val Asn  Thr Cys Asn 
    1250                 1255                 1260             


Pro Ser  Thr Ile Thr Gly Thr  Leu Ser Arg Leu Ser  Leu Asp Glu 
    1265                 1270                 1275             


Asp Glu  Glu Pro Lys Ser Cys  Leu Val Gly Pro Glu  Gly Ser Leu 
    1280                 1285                 1290             


Ser Phe  Ser Pro Leu Pro Gly  Asn Ile Leu Val Pro  Met Ala Ala 
    1295                 1300                 1305             


Ser Pro  Gly Leu Gly Glu Pro  Pro Pro Pro Gln Glu  Ala Asn Pro 
    1310                 1315                 1320             


Val Tyr  Met Cys Gly Glu Gly  Gly Leu Arg Gln Leu  Asp Leu Thr 
    1325                 1330                 1335             


Trp Leu  Arg Pro Thr Glu Pro  Gly Ser Glu Gly Asp  Tyr Met Val 
    1340                 1345                 1350             


Leu Pro  Arg Arg Thr Leu Ser  Leu Gln Pro Gly Gly  Gly Gly Gly 
    1355                 1360                 1365             


Gly Gly  Glu Asp Ala Pro Arg  Ala Arg Pro Glu Gly  Thr Pro Arg 
    1370                 1375                 1380             


Arg Ala  Ala Lys Thr Val Ala  His Thr Glu Gly Tyr  Pro Ser Phe 
    1385                 1390                 1395             


Leu Ser  Val Asp His Ser Gly  Leu Gly Leu Gly Pro  Ala Tyr Gly 
    1400                 1405                 1410             


Ser Leu  Gln Asn Pro Tyr Gly  Met Thr Phe Gln Pro  Pro Pro Pro 
    1415                 1420                 1425             


Thr Pro  Ser Ala Arg Gln Val  Pro Glu Pro Gly Glu  Arg Ser Arg 
    1430                 1435                 1440             


Thr Met  Pro Arg Thr Val Pro  Gly Ser Thr Met Lys  Met Gly Ser 
    1445                 1450                 1455             


Leu Glu  Arg Lys Lys Leu Arg  Tyr Ser Asp Leu Asp  Phe Glu Val 
    1460                 1465                 1470             


Met His  Thr Arg Lys Arg His  Ser Glu Leu Tyr His  Glu Leu Asn 
    1475                 1480                 1485             


Gln Lys  Phe His Thr Phe Asp  Arg Tyr Arg Ser Gln  Ser Thr Ala 
    1490                 1495                 1500             


Lys Arg  Glu Lys Arg Trp Ser  Val Ser Ser Gly Gly  Ala Ala Glu 
    1505                 1510                 1515             


Arg Ser  Val Cys Thr Asp Lys  Pro Ser Pro Gly Glu  Arg Pro Ser 
    1520                 1525                 1530             


Leu Ser  Gln His Arg Arg His  Gln Ser Trp Ser Thr  Phe Lys Ser 
    1535                 1540                 1545             


Met Thr  Leu Gly Ser Leu Pro  Pro Lys Pro Arg Glu  Arg Leu Thr 
    1550                 1555                 1560             


Leu His  Arg Ala Ala Ala Trp  Glu Pro Thr Glu Pro  Pro Asp Gly 
    1565                 1570                 1575             


Asp Phe  Gln Thr Glu Val 
    1580                 


<210>  420
<211>  1551
<212>  PRT
<213>  Homo Sapiens

<400>  420

Met Glu Asn Thr Gly Trp Met Gly Lys Gly His Arg Met Thr Pro Ala 
1               5                   10                  15      


Cys Pro Leu Leu Leu Ser Val Ile Leu Ser Leu Arg Leu Ala Thr Ala 
            20                  25                  30          


Phe Asp Pro Ala Pro Ser Ala Cys Ser Ala Leu Ala Ser Gly Val Leu 
        35                  40                  45              


Tyr Gly Ala Phe Ser Leu Gln Asp Leu Phe Pro Thr Ile Ala Ser Gly 
    50                  55                  60                  


Cys Ser Trp Thr Leu Glu Asn Pro Asp Pro Thr Lys Tyr Ser Leu Tyr 
65                  70                  75                  80  


Leu Arg Phe Asn Arg Gln Glu Gln Val Cys Ala His Phe Ala Pro Arg 
                85                  90                  95      


Leu Leu Pro Leu Asp His Tyr Leu Val Asn Phe Thr Cys Leu Arg Pro 
            100                 105                 110         


Ser Pro Glu Glu Ala Val Ala Gln Ala Glu Ser Glu Val Gly Arg Pro 
        115                 120                 125             


Glu Glu Glu Glu Ala Glu Ala Ala Ala Gly Leu Glu Leu Cys Ser Gly 
    130                 135                 140                 


Ser Gly Pro Phe Thr Phe Leu His Phe Asp Lys Asn Phe Val Gln Leu 
145                 150                 155                 160 


Cys Leu Ser Ala Glu Pro Ser Glu Ala Pro Arg Leu Leu Ala Pro Ala 
                165                 170                 175     


Ala Leu Ala Phe Arg Phe Val Glu Val Leu Leu Ile Asn Asn Asn Asn 
            180                 185                 190         


Ser Ser Gln Phe Thr Cys Gly Val Leu Cys Arg Trp Ser Glu Glu Cys 
        195                 200                 205             


Gly Arg Ala Ala Gly Arg Ala Cys Gly Phe Ala Gln Pro Gly Cys Ser 
    210                 215                 220                 


Cys Pro Gly Glu Ala Gly Ala Gly Ser Thr Thr Thr Thr Ser Pro Gly 
225                 230                 235                 240 


Pro Pro Ala Ala His Thr Leu Ser Asn Ala Leu Val Pro Gly Gly Pro 
                245                 250                 255     


Ala Pro Pro Ala Glu Ala Asp Leu His Ser Gly Ser Ser Asn Asp Leu 
            260                 265                 270         


Phe Thr Thr Glu Met Arg Tyr Gly Glu Glu Pro Glu Glu Glu Pro Lys 
        275                 280                 285             


Val Lys Thr Gln Trp Pro Arg Ser Ala Asp Glu Pro Gly Leu Tyr Met 
    290                 295                 300                 


Ala Gln Thr Gly Asp Pro Ala Ala Glu Glu Trp Ser Pro Trp Ser Val 
305                 310                 315                 320 


Cys Ser Leu Thr Cys Gly Gln Gly Leu Gln Val Arg Thr Arg Ser Cys 
                325                 330                 335     


Val Ser Ser Pro Tyr Gly Thr Leu Cys Ser Gly Pro Leu Arg Glu Thr 
            340                 345                 350         


Arg Pro Cys Asn Asn Ser Ala Thr Cys Pro Val His Gly Val Trp Glu 
        355                 360                 365             


Glu Trp Gly Ser Trp Ser Leu Cys Ser Arg Ser Cys Gly Arg Gly Ser 
    370                 375                 380                 


Arg Ser Arg Met Arg Thr Cys Val Pro Pro Gln His Gly Gly Lys Ala 
385                 390                 395                 400 


Cys Glu Gly Pro Glu Leu Gln Thr Lys Leu Cys Ser Met Ala Ala Cys 
                405                 410                 415     


Pro Val Glu Gly Gln Trp Leu Glu Trp Gly Pro Trp Gly Pro Cys Ser 
            420                 425                 430         


Thr Ser Cys Ala Asn Gly Thr Gln Gln Arg Ser Arg Lys Cys Ser Val 
        435                 440                 445             


Ala Gly Pro Ala Trp Ala Thr Cys Thr Gly Ala Leu Thr Asp Thr Arg 
    450                 455                 460                 


Glu Cys Ser Asn Leu Glu Cys Pro Ala Thr Asp Ser Lys Trp Gly Pro 
465                 470                 475                 480 


Trp Asn Ala Trp Ser Leu Cys Ser Lys Thr Cys Asp Thr Gly Trp Gln 
                485                 490                 495     


Arg Arg Phe Arg Met Cys Gln Ala Thr Gly Thr Gln Gly Tyr Pro Cys 
            500                 505                 510         


Glu Gly Thr Gly Glu Glu Val Lys Pro Cys Ser Glu Lys Arg Cys Pro 
        515                 520                 525             


Ala Phe His Glu Met Cys Arg Asp Glu Tyr Val Met Leu Met Thr Trp 
    530                 535                 540                 


Lys Lys Ala Ala Ala Gly Glu Ile Ile Tyr Asn Lys Cys Pro Pro Asn 
545                 550                 555                 560 


Ala Ser Gly Ser Ala Ser Arg Arg Cys Leu Leu Ser Ala Gln Gly Val 
                565                 570                 575     


Ala Tyr Trp Gly Leu Pro Ser Phe Ala Arg Cys Ile Ser His Glu Tyr 
            580                 585                 590         


Arg Tyr Leu Tyr Leu Ser Leu Arg Glu His Leu Ala Lys Gly Gln Arg 
        595                 600                 605             


Met Leu Ala Gly Glu Gly Met Ser Gln Val Val Arg Ser Leu Gln Glu 
    610                 615                 620                 


Leu Leu Ala Arg Arg Thr Tyr Tyr Ser Gly Asp Leu Leu Phe Ser Val 
625                 630                 635                 640 


Asp Ile Leu Arg Asn Val Thr Asp Thr Phe Lys Arg Ala Thr Tyr Val 
                645                 650                 655     


Pro Ser Ala Asp Asp Val Gln Arg Phe Phe Gln Val Val Ser Phe Met 
            660                 665                 670         


Val Asp Ala Glu Asn Lys Glu Lys Trp Asp Asp Ala Gln Gln Val Ser 
        675                 680                 685             


Pro Gly Ser Val His Leu Leu Arg Val Val Glu Asp Phe Ile His Leu 
    690                 695                 700                 


Val Gly Asp Ala Leu Lys Ala Phe Gln Ser Ser Leu Ile Val Thr Asp 
705                 710                 715                 720 


Asn Leu Val Ile Ser Ile Gln Arg Glu Pro Val Ser Ala Val Ser Ser 
                725                 730                 735     


Asp Ile Thr Phe Pro Met Arg Gly Arg Arg Gly Met Lys Asp Trp Val 
            740                 745                 750         


Arg His Ser Glu Asp Arg Leu Phe Leu Pro Lys Glu Val Leu Ser Leu 
        755                 760                 765             


Ser Ser Pro Gly Lys Pro Ala Thr Ser Gly Ala Ala Gly Ser Pro Gly 
    770                 775                 780                 


Arg Gly Arg Gly Pro Gly Thr Val Pro Pro Gly Pro Gly His Ser His 
785                 790                 795                 800 


Gln Arg Leu Leu Pro Ala Asp Pro Asp Glu Ser Ser Tyr Phe Val Ile 
                805                 810                 815     


Gly Ala Val Leu Tyr Arg Thr Leu Gly Leu Ile Leu Pro Pro Pro Arg 
            820                 825                 830         


Pro Pro Leu Ala Val Thr Ser Arg Val Met Thr Val Thr Val Arg Pro 
        835                 840                 845             


Pro Thr Gln Pro Pro Ala Glu Pro Leu Ile Thr Val Glu Leu Ser Tyr 
    850                 855                 860                 


Ile Ile Asn Gly Thr Thr Asp Pro His Cys Ala Ser Trp Asp Tyr Ser 
865                 870                 875                 880 


Arg Ala Asp Ala Ser Ser Gly Asp Trp Asp Thr Glu Asn Cys Gln Thr 
                885                 890                 895     


Leu Glu Thr Gln Ala Ala His Thr Arg Cys Gln Cys Gln His Leu Ser 
            900                 905                 910         


Thr Phe Ala Val Leu Ala Gln Pro Pro Lys Asp Leu Thr Leu Glu Leu 
        915                 920                 925             


Ala Gly Ser Pro Ser Val Pro Leu Val Ile Gly Cys Ala Val Ser Cys 
    930                 935                 940                 


Met Ala Leu Leu Thr Leu Leu Ala Ile Tyr Ala Ala Phe Trp Arg Phe 
945                 950                 955                 960 


Ile Lys Ser Glu Arg Ser Ile Ile Leu Leu Asn Phe Cys Leu Ser Ile 
                965                 970                 975     


Leu Ala Ser Asn Ile Leu Ile Leu Val Gly Gln Ser Arg Val Leu Ser 
            980                 985                 990         


Lys Gly Val Cys Thr Met Thr Ala  Ala Phe Leu His Phe  Phe Phe Leu 
        995                 1000                 1005             


Ser Ser  Phe Cys Trp Val Leu  Thr Glu Ala Trp Gln  Ser Tyr Leu 
    1010                 1015                 1020             


Ala Val  Ile Gly Arg Met Arg  Thr Arg Leu Val Arg  Lys Arg Phe 
    1025                 1030                 1035             


Leu Cys  Leu Gly Trp Gly Leu  Pro Ala Leu Val Val  Ala Val Ser 
    1040                 1045                 1050             


Val Gly  Phe Thr Arg Thr Lys  Gly Tyr Gly Thr Ser  Ser Tyr Cys 
    1055                 1060                 1065             


Trp Leu  Ser Leu Glu Gly Gly  Leu Leu Tyr Ala Phe  Val Gly Pro 
    1070                 1075                 1080             


Ala Ala  Val Ile Val Leu Val  Asn Met Leu Ile Gly  Ile Ile Val 
    1085                 1090                 1095             


Phe Asn  Lys Leu Met Ala Arg  Asp Gly Ile Ser Asp  Lys Ser Lys 
    1100                 1105                 1110             


Lys Gln  Arg Ala Gly Ala Ser  Leu Trp Ser Ser Cys  Val Val Leu 
    1115                 1120                 1125             


Pro Leu  Leu Ala Leu Thr Trp  Met Ser Ala Val Leu  Ala Met Thr 
    1130                 1135                 1140             


Asp Arg  Arg Ser Val Leu Phe  Gln Ala Leu Phe Ala  Val Phe Asn 
    1145                 1150                 1155             


Ser Ala  Gln Gly Phe Val Ile  Thr Ala Val His Cys  Phe Leu Arg 
    1160                 1165                 1170             


Arg Glu  Val Gln Asp Val Val  Lys Cys Gln Met Gly  Val Cys Arg 
    1175                 1180                 1185             


Ala Asp  Glu Ser Glu Asp Ser  Pro Asp Ser Cys Lys  Asn Gly Gln 
    1190                 1195                 1200             


Leu Gln  Ile Leu Ser Asp Phe  Glu Lys Asp Val Asp  Leu Ala Cys 
    1205                 1210                 1215             


Gln Thr  Val Leu Phe Lys Glu  Val Asn Thr Cys Asn  Pro Ser Thr 
    1220                 1225                 1230             


Ile Thr  Gly Thr Leu Ser Arg  Leu Ser Leu Asp Glu  Asp Glu Glu 
    1235                 1240                 1245             


Pro Lys  Ser Cys Leu Val Gly  Pro Glu Gly Ser Leu  Ser Phe Ser 
    1250                 1255                 1260             


Pro Leu  Pro Gly Asn Ile Leu  Val Pro Met Ala Ala  Ser Pro Gly 
    1265                 1270                 1275             


Leu Gly  Glu Pro Pro Pro Pro  Gln Glu Ala Asn Pro  Val Tyr Met 
    1280                 1285                 1290             


Cys Gly  Glu Gly Gly Leu Arg  Gln Leu Asp Leu Thr  Trp Leu Arg 
    1295                 1300                 1305             


Pro Thr  Glu Pro Gly Ser Glu  Gly Asp Tyr Met Val  Leu Pro Arg 
    1310                 1315                 1320             


Arg Thr  Leu Ser Leu Gln Pro  Gly Gly Gly Gly Gly  Gly Gly Glu 
    1325                 1330                 1335             


Asp Ala  Pro Arg Ala Arg Pro  Glu Gly Thr Pro Arg  Arg Ala Ala 
    1340                 1345                 1350             


Lys Thr  Val Ala His Thr Glu  Gly Tyr Pro Ser Phe  Leu Ser Val 
    1355                 1360                 1365             


Asp His  Ser Gly Leu Gly Leu  Gly Pro Ala Tyr Gly  Ser Leu Gln 
    1370                 1375                 1380             


Asn Pro  Tyr Gly Met Thr Phe  Gln Pro Pro Pro Pro  Thr Pro Ser 
    1385                 1390                 1395             


Ala Arg  Gln Val Pro Glu Pro  Gly Glu Arg Ser Arg  Thr Met Pro 
    1400                 1405                 1410             


Arg Thr  Val Pro Gly Ser Thr  Met Lys Met Gly Ser  Leu Glu Arg 
    1415                 1420                 1425             


Lys Lys  Leu Arg Tyr Ser Asp  Leu Asp Phe Glu Val  Met His Thr 
    1430                 1435                 1440             


Arg Lys  Arg His Ser Glu Leu  Tyr His Glu Leu Asn  Gln Lys Phe 
    1445                 1450                 1455             


His Thr  Phe Asp Arg Tyr Arg  Ser Gln Ser Thr Ala  Lys Arg Glu 
    1460                 1465                 1470             


Lys Arg  Trp Ser Val Ser Ser  Gly Gly Ala Ala Glu  Arg Ser Val 
    1475                 1480                 1485             


Cys Thr  Asp Lys Pro Ser Pro  Gly Glu Arg Pro Ser  Leu Ser Gln 
    1490                 1495                 1500             


His Arg  Arg His Gln Ser Trp  Ser Thr Phe Lys Ser  Met Thr Leu 
    1505                 1510                 1515             


Gly Ser  Leu Pro Pro Lys Pro  Arg Glu Arg Leu Thr  Leu His Arg 
    1520                 1525                 1530             


Ala Ala  Ala Trp Glu Pro Thr  Glu Pro Pro Asp Gly  Asp Phe Gln 
    1535                 1540                 1545             


Thr Glu  Val 
    1550     


<210>  421
<211>  507
<212>  PRT
<213>  Homo Sapiens

<400>  421

Met His Leu Pro Arg Gln His Gly Ser Ala His Leu Gly His Leu Tyr 
1               5                   10                  15      


Ala Tyr Ala Lys Phe Ser Ala His Asp Trp His Leu His Ala Gln Gly 
            20                  25                  30          


His Ala Ile Cys Asn Ala His Gly Lys Gly Lys Gly His Arg Met Thr 
        35                  40                  45              


Pro Ala Cys Pro Leu Leu Leu Ser Val Ile Leu Ser Leu Arg Leu Ala 
    50                  55                  60                  


Thr Ala Phe Asp Pro Ala Pro Ser Ala Cys Ser Ala Leu Ala Ser Gly 
65                  70                  75                  80  


Val Leu Tyr Gly Ala Phe Ser Leu Gln Asp Leu Phe Pro Thr Ile Ala 
                85                  90                  95      


Ser Gly Cys Ser Trp Thr Leu Glu Asn Pro Asp Pro Thr Lys Tyr Ser 
            100                 105                 110         


Leu Tyr Leu Arg Phe Asn Arg Gln Glu Gln Val Cys Ala His Phe Ala 
        115                 120                 125             


Pro Arg Leu Leu Pro Leu Asp His Tyr Leu Val Asn Phe Thr Cys Leu 
    130                 135                 140                 


Arg Pro Ser Pro Glu Glu Ala Val Ala Gln Ala Glu Ser Glu Val Gly 
145                 150                 155                 160 


Arg Pro Glu Glu Glu Glu Ala Glu Ala Ala Ala Gly Leu Glu Leu Cys 
                165                 170                 175     


Ser Gly Ser Gly Pro Phe Thr Phe Leu His Phe Asp Lys Asn Phe Val 
            180                 185                 190         


Gln Leu Cys Leu Ser Ala Glu Pro Ser Glu Ala Pro Arg Leu Leu Ala 
        195                 200                 205             


Pro Ala Ala Leu Ala Phe Arg Phe Val Glu Val Leu Leu Ile Asn Asn 
    210                 215                 220                 


Asn Asn Ser Ser Gln Phe Thr Cys Gly Val Leu Cys Arg Trp Ser Glu 
225                 230                 235                 240 


Glu Cys Gly Arg Ala Ala Gly Arg Ala Cys Gly Phe Ala Gln Pro Gly 
                245                 250                 255     


Cys Ser Cys Pro Gly Glu Ala Gly Ala Gly Ser Thr Thr Thr Thr Ser 
            260                 265                 270         


Pro Gly Pro Pro Ala Ala His Thr Leu Ser Asn Ala Leu Val Pro Gly 
        275                 280                 285             


Gly Pro Ala Pro Pro Ala Glu Ala Asp Leu His Ser Gly Ser Ser Asn 
    290                 295                 300                 


Asp Leu Phe Thr Thr Glu Met Arg Tyr Gly Glu Glu Pro Glu Glu Glu 
305                 310                 315                 320 


Pro Lys Val Lys Thr Gln Trp Pro Arg Ser Ala Asp Glu Pro Gly Leu 
                325                 330                 335     


Tyr Met Ala Gln Thr Val His Gly Val Trp Glu Glu Trp Gly Ser Trp 
            340                 345                 350         


Ser Leu Cys Ser Arg Ser Cys Gly Arg Gly Ser Arg Ser Arg Met Arg 
        355                 360                 365             


Thr Cys Val Pro Pro Gln His Gly Gly Lys Ala Cys Glu Gly Pro Glu 
    370                 375                 380                 


Leu Gln Thr Lys Leu Cys Ser Met Ala Ala Cys Pro Val Glu Gly Gln 
385                 390                 395                 400 


Trp Leu Glu Trp Gly Pro Trp Gly Pro Cys Ser Thr Ser Cys Ala Asn 
                405                 410                 415     


Gly Thr Gln Gln Arg Ser Arg Lys Cys Ser Val Ala Gly Pro Ala Trp 
            420                 425                 430         


Ala Thr Cys Thr Gly Ala Leu Thr Asp Thr Arg Glu Cys Ser Asn Leu 
        435                 440                 445             


Glu Cys Pro Ala Thr Asp Ser Lys Trp Gly Pro Trp Asn Ala Trp Ser 
    450                 455                 460                 


Leu Cys Ser Lys Thr Cys Asp Thr Gly Trp Gln Arg Arg Phe Arg Met 
465                 470                 475                 480 


Cys Gln Ala Thr Gly Thr Gln Gly Tyr Pro Cys Glu Gly Thr Gly Glu 
                485                 490                 495     


Glu Val Lys Pro Cys Ser Glu Lys Arg Cys Pro 
            500                 505         


<210>  422
<211>  1500
<212>  PRT
<213>  Homo Sapiens

<400>  422

Met Leu Ser Leu Arg Gly Pro Asp Thr His Gly Lys Gly His Arg Met 
1               5                   10                  15      


Thr Pro Ala Cys Pro Leu Leu Leu Ser Val Ile Leu Ser Leu Arg Leu 
            20                  25                  30          


Ala Thr Ala Phe Asp Pro Ala Pro Ser Ala Cys Ser Ala Leu Ala Ser 
        35                  40                  45              


Gly Val Leu Tyr Gly Ala Phe Ser Leu Gln Asp Leu Phe Pro Thr Ile 
    50                  55                  60                  


Ala Ser Gly Cys Ser Trp Thr Leu Glu Asn Pro Asp Pro Thr Lys Tyr 
65                  70                  75                  80  


Ser Leu Tyr Leu Arg Phe Asn Arg Gln Glu Gln Val Cys Ala His Phe 
                85                  90                  95      


Ala Pro Arg Leu Leu Pro Leu Asp His Tyr Leu Val Asn Phe Thr Cys 
            100                 105                 110         


Leu Arg Pro Ser Pro Glu Glu Ala Val Ala Gln Ala Glu Ser Glu Val 
        115                 120                 125             


Gly Arg Pro Glu Glu Glu Glu Ala Glu Ala Ala Ala Gly Leu Glu Leu 
    130                 135                 140                 


Cys Ser Gly Ser Gly Pro Phe Thr Phe Leu His Phe Asp Lys Asn Phe 
145                 150                 155                 160 


Val Gln Leu Cys Leu Ser Ala Glu Pro Ser Glu Ala Pro Arg Leu Leu 
                165                 170                 175     


Ala Pro Ala Ala Leu Ala Phe Arg Phe Val Glu Val Leu Leu Ile Asn 
            180                 185                 190         


Asn Asn Asn Ser Ser Gln Phe Thr Cys Gly Val Leu Cys Arg Trp Ser 
        195                 200                 205             


Glu Glu Cys Gly Arg Ala Ala Gly Arg Ala Cys Gly Phe Ala Gln Pro 
    210                 215                 220                 


Gly Cys Ser Cys Pro Gly Glu Ala Gly Ala Gly Ser Thr Thr Thr Thr 
225                 230                 235                 240 


Ser Pro Gly Pro Pro Ala Ala His Thr Leu Ser Asn Ala Leu Val Pro 
                245                 250                 255     


Gly Gly Pro Ala Pro Pro Ala Glu Ala Asp Leu His Ser Gly Ser Ser 
            260                 265                 270         


Asn Asp Leu Phe Thr Thr Glu Met Arg Tyr Gly Glu Glu Pro Glu Glu 
        275                 280                 285             


Glu Pro Lys Val Lys Thr Gln Trp Pro Arg Ser Ala Asp Glu Pro Gly 
    290                 295                 300                 


Leu Tyr Met Ala Gln Thr Val His Gly Val Trp Glu Glu Trp Gly Ser 
305                 310                 315                 320 


Trp Ser Leu Cys Ser Arg Ser Cys Gly Arg Gly Ser Arg Ser Arg Met 
                325                 330                 335     


Arg Thr Cys Val Pro Pro Gln His Gly Gly Lys Ala Cys Glu Gly Pro 
            340                 345                 350         


Glu Leu Gln Thr Lys Leu Cys Ser Met Ala Ala Cys Pro Val Glu Gly 
        355                 360                 365             


Gln Trp Leu Glu Trp Gly Pro Trp Gly Pro Cys Ser Thr Ser Cys Ala 
    370                 375                 380                 


Asn Gly Thr Gln Gln Arg Ser Arg Lys Cys Ser Val Ala Gly Pro Ala 
385                 390                 395                 400 


Trp Ala Thr Cys Thr Gly Ala Leu Thr Asp Thr Arg Glu Cys Ser Asn 
                405                 410                 415     


Leu Glu Cys Pro Ala Thr Asp Ser Lys Trp Gly Pro Trp Asn Ala Trp 
            420                 425                 430         


Ser Leu Cys Ser Lys Thr Cys Asp Thr Gly Trp Gln Arg Arg Phe Arg 
        435                 440                 445             


Met Cys Gln Ala Thr Gly Thr Gln Gly Tyr Pro Cys Glu Gly Thr Gly 
    450                 455                 460                 


Glu Glu Val Lys Pro Cys Ser Glu Lys Arg Cys Pro Ala Phe His Glu 
465                 470                 475                 480 


Met Cys Arg Asp Glu Tyr Val Met Leu Met Thr Trp Lys Lys Ala Ala 
                485                 490                 495     


Ala Gly Glu Ile Ile Tyr Asn Lys Cys Pro Pro Asn Ala Ser Gly Ser 
            500                 505                 510         


Ala Ser Arg Arg Cys Leu Leu Ser Ala Gln Gly Val Ala Tyr Trp Gly 
        515                 520                 525             


Leu Pro Ser Phe Ala Arg Cys Ile Ser His Glu Tyr Arg Tyr Leu Tyr 
    530                 535                 540                 


Leu Ser Leu Arg Glu His Leu Ala Lys Gly Gln Arg Met Leu Ala Gly 
545                 550                 555                 560 


Glu Gly Met Ser Gln Val Val Arg Ser Leu Gln Glu Leu Leu Ala Arg 
                565                 570                 575     


Arg Thr Tyr Tyr Ser Gly Asp Leu Leu Phe Ser Val Asp Ile Leu Arg 
            580                 585                 590         


Asn Val Thr Asp Thr Phe Lys Arg Ala Thr Tyr Val Pro Ser Ala Asp 
        595                 600                 605             


Asp Val Gln Arg Phe Phe Gln Val Val Ser Phe Met Val Asp Ala Glu 
    610                 615                 620                 


Asn Lys Glu Lys Trp Asp Asp Ala Gln Gln Val Ser Pro Gly Ser Val 
625                 630                 635                 640 


His Leu Leu Arg Val Val Glu Asp Phe Ile His Leu Val Gly Asp Ala 
                645                 650                 655     


Leu Lys Ala Phe Gln Ser Ser Leu Ile Val Thr Asp Asn Leu Val Ile 
            660                 665                 670         


Ser Ile Gln Arg Glu Pro Val Ser Ala Val Ser Ser Asp Ile Thr Phe 
        675                 680                 685             


Pro Met Arg Gly Arg Arg Gly Met Lys Asp Trp Val Arg His Ser Glu 
    690                 695                 700                 


Asp Arg Leu Phe Leu Pro Lys Glu Val Leu Ser Leu Ser Ser Pro Gly 
705                 710                 715                 720 


Lys Pro Ala Thr Ser Gly Ala Ala Gly Ser Pro Gly Arg Gly Arg Gly 
                725                 730                 735     


Pro Gly Thr Val Pro Pro Gly Pro Gly His Ser His Gln Arg Leu Leu 
            740                 745                 750         


Pro Ala Asp Pro Asp Glu Ser Ser Tyr Phe Val Ile Gly Ala Val Leu 
        755                 760                 765             


Tyr Arg Thr Leu Gly Leu Ile Leu Pro Pro Pro Arg Pro Pro Leu Ala 
    770                 775                 780                 


Val Thr Ser Arg Val Met Thr Val Thr Val Arg Pro Pro Thr Gln Pro 
785                 790                 795                 800 


Pro Ala Glu Pro Leu Ile Thr Val Glu Leu Ser Tyr Ile Ile Asn Gly 
                805                 810                 815     


Thr Thr Asp Pro His Cys Ala Ser Trp Asp Tyr Ser Arg Ala Asp Ala 
            820                 825                 830         


Ser Ser Gly Asp Trp Asp Thr Glu Asn Cys Gln Thr Leu Glu Thr Gln 
        835                 840                 845             


Ala Ala His Thr Arg Cys Gln Cys Gln His Leu Ser Thr Phe Ala Val 
    850                 855                 860                 


Leu Ala Gln Pro Pro Lys Asp Leu Thr Leu Glu Leu Ala Gly Ser Pro 
865                 870                 875                 880 


Ser Val Pro Leu Val Ile Gly Cys Ala Val Ser Cys Met Ala Leu Leu 
                885                 890                 895     


Thr Leu Leu Ala Ile Tyr Ala Ala Phe Trp Arg Phe Ile Lys Ser Glu 
            900                 905                 910         


Arg Ser Ile Ile Leu Leu Asn Phe Cys Leu Ser Ile Leu Ala Ser Asn 
        915                 920                 925             


Ile Leu Ile Leu Val Gly Gln Ser Arg Val Leu Ser Lys Gly Val Cys 
    930                 935                 940                 


Thr Met Thr Ala Ala Phe Leu His Phe Phe Phe Leu Ser Ser Phe Cys 
945                 950                 955                 960 


Trp Val Leu Thr Glu Ala Trp Gln Ser Tyr Leu Ala Val Ile Gly Arg 
                965                 970                 975     


Met Arg Thr Arg Leu Val Arg Lys Arg Phe Leu Cys Leu Gly Trp Gly 
            980                 985                 990         


Leu Pro Ala Leu Val Val Ala Val  Ser Val Gly Phe Thr  Arg Thr Lys 
        995                 1000                 1005             


Gly Tyr  Gly Thr Ser Ser Tyr  Cys Trp Leu Ser Leu  Glu Gly Gly 
    1010                 1015                 1020             


Leu Leu  Tyr Ala Phe Val Gly  Pro Ala Ala Val Ile  Val Leu Val 
    1025                 1030                 1035             


Asn Met  Leu Ile Gly Ile Ile  Val Phe Asn Lys Leu  Met Ala Arg 
    1040                 1045                 1050             


Asp Gly  Ile Ser Asp Lys Ser  Lys Lys Gln Arg Ala  Gly Ala Ser 
    1055                 1060                 1065             


Leu Trp  Ser Ser Cys Val Val  Leu Pro Leu Leu Ala  Leu Thr Trp 
    1070                 1075                 1080             


Met Ser  Ala Val Leu Ala Met  Thr Asp Arg Arg Ser  Val Leu Phe 
    1085                 1090                 1095             


Gln Ala  Leu Phe Ala Val Phe  Asn Ser Ala Gln Gly  Phe Val Ile 
    1100                 1105                 1110             


Thr Ala  Val His Cys Phe Leu  Arg Arg Glu Val Gln  Asp Val Val 
    1115                 1120                 1125             


Lys Cys  Gln Met Gly Val Cys  Arg Ala Asp Glu Ser  Glu Asp Ser 
    1130                 1135                 1140             


Pro Asp  Ser Cys Lys Asn Gly  Gln Leu Gln Ile Leu  Ser Asp Phe 
    1145                 1150                 1155             


Glu Lys  Asp Val Asp Leu Ala  Cys Gln Thr Val Leu  Phe Lys Glu 
    1160                 1165                 1170             


Val Asn  Thr Cys Asn Pro Ser  Thr Ile Thr Gly Thr  Leu Ser Arg 
    1175                 1180                 1185             


Leu Ser  Leu Asp Glu Asp Glu  Glu Pro Lys Ser Cys  Leu Val Gly 
    1190                 1195                 1200             


Pro Glu  Gly Ser Leu Ser Phe  Ser Pro Leu Pro Gly  Asn Ile Leu 
    1205                 1210                 1215             


Val Pro  Met Ala Ala Ser Pro  Gly Leu Gly Glu Pro  Pro Pro Pro 
    1220                 1225                 1230             


Gln Glu  Ala Asn Pro Val Tyr  Met Cys Gly Glu Gly  Gly Leu Arg 
    1235                 1240                 1245             


Gln Leu  Asp Leu Thr Trp Leu  Arg Pro Thr Glu Pro  Gly Ser Glu 
    1250                 1255                 1260             


Gly Asp  Tyr Met Val Leu Pro  Arg Arg Thr Leu Ser  Leu Gln Pro 
    1265                 1270                 1275             


Gly Gly  Gly Gly Gly Gly Gly  Glu Asp Ala Pro Arg  Ala Arg Pro 
    1280                 1285                 1290             


Glu Gly  Thr Pro Arg Arg Ala  Ala Lys Thr Val Ala  His Thr Glu 
    1295                 1300                 1305             


Gly Tyr  Pro Ser Phe Leu Ser  Val Asp His Ser Gly  Leu Gly Leu 
    1310                 1315                 1320             


Gly Pro  Ala Tyr Gly Ser Leu  Gln Asn Pro Tyr Gly  Met Thr Phe 
    1325                 1330                 1335             


Gln Pro  Pro Pro Pro Thr Pro  Ser Ala Arg Gln Val  Pro Glu Pro 
    1340                 1345                 1350             


Gly Glu  Arg Ser Arg Thr Met  Pro Arg Thr Val Pro  Gly Ser Thr 
    1355                 1360                 1365             


Met Lys  Met Gly Ser Leu Glu  Arg Lys Lys Leu Arg  Tyr Ser Asp 
    1370                 1375                 1380             


Leu Asp  Phe Glu Lys Val Met  His Thr Arg Lys Arg  His Ser Glu 
    1385                 1390                 1395             


Leu Tyr  His Glu Leu Asn Gln  Lys Phe His Thr Phe  Asp Arg Tyr 
    1400                 1405                 1410             


Arg Ser  Gln Ser Thr Ala Lys  Arg Glu Lys Arg Trp  Ser Val Ser 
    1415                 1420                 1425             


Ser Gly  Gly Ala Ala Glu Arg  Ser Val Cys Thr Asp  Lys Pro Ser 
    1430                 1435                 1440             


Pro Gly  Glu Arg Pro Ser Leu  Ser Gln His Arg Arg  His Gln Ser 
    1445                 1450                 1455             


Trp Ser  Thr Phe Lys Ser Met  Thr Leu Gly Ser Leu  Pro Pro Lys 
    1460                 1465                 1470             


Pro Arg  Glu Arg Leu Thr Leu  His Arg Ala Ala Ala  Trp Glu Pro 
    1475                 1480                 1485             


Thr Glu  Pro Pro Asp Gly Asp  Phe Gln Thr Glu Val  
    1490                 1495                 1500 


<210>  423
<211>  1554
<212>  PRT
<213>  Homo Sapiens

<400>  423

Met Thr Pro Ala Cys Pro Leu Leu Leu Ser Val Ile Leu Ser Leu Arg 
1               5                   10                  15      


Leu Ala Thr Ala Phe Asp Pro Ala Pro Ser Ala Cys Ser Ala Leu Ala 
            20                  25                  30          


Ser Gly Val Leu Tyr Gly Ala Phe Ser Leu Gln Asp Leu Phe Pro Thr 
        35                  40                  45              


Ile Ala Ser Gly Cys Ser Trp Thr Leu Glu Asn Pro Asp Pro Thr Lys 
    50                  55                  60                  


Tyr Ser Leu Tyr Leu Arg Phe Asn Arg Gln Glu Gln Val Cys Ala His 
65                  70                  75                  80  


Phe Ala Pro Arg Leu Leu Pro Leu Asp His Tyr Leu Val Asn Phe Thr 
                85                  90                  95      


Cys Leu Arg Pro Ser Pro Glu Glu Ala Val Ala Gln Ala Glu Ser Glu 
            100                 105                 110         


Val Gly Arg Pro Glu Glu Glu Glu Ala Glu Ala Ala Ala Gly Leu Glu 
        115                 120                 125             


Leu Cys Ser Gly Ser Gly Pro Phe Thr Phe Leu His Phe Asp Lys Asn 
    130                 135                 140                 


Phe Val Gln Leu Cys Leu Ser Ala Glu Pro Ser Glu Ala Pro Arg Leu 
145                 150                 155                 160 


Leu Ala Pro Ala Ala Leu Ala Phe Arg Phe Val Glu Val Leu Leu Ile 
                165                 170                 175     


Asn Asn Asn Asn Ser Ser Gln Phe Thr Cys Gly Val Leu Cys Arg Trp 
            180                 185                 190         


Ser Glu Glu Cys Gly Arg Ala Ala Gly Arg Ala Cys Gly Phe Ala Gln 
        195                 200                 205             


Pro Gly Cys Ser Cys Pro Gly Glu Ala Gly Ala Gly Ser Thr Thr Thr 
    210                 215                 220                 


Thr Ser Pro Gly Pro Pro Ala Ala His Thr Leu Ser Asn Ala Leu Val 
225                 230                 235                 240 


Pro Gly Gly Pro Ala Pro Pro Ala Glu Ala Asp Leu His Ser Gly Ser 
                245                 250                 255     


Ser Asn Asp Leu Phe Thr Thr Glu Met Arg Tyr Gly Glu Glu Pro Glu 
            260                 265                 270         


Glu Glu Pro Lys Val Lys Thr Gln Trp Pro Arg Ser Ala Asp Glu Pro 
        275                 280                 285             


Gly Leu Tyr Met Ala Gln Thr Gly Asp Pro Ala Ala Glu Glu Trp Ser 
    290                 295                 300                 


Pro Trp Ser Val Cys Ser Leu Thr Cys Gly Gln Gly Leu Gln Val Arg 
305                 310                 315                 320 


Thr Arg Ser Cys Val Ser Ser Pro Tyr Gly Thr Leu Cys Ser Gly Pro 
                325                 330                 335     


Leu Arg Glu Thr Arg Pro Cys Asn Asn Ser Ala Thr Cys Pro Val His 
            340                 345                 350         


Gly Val Trp Glu Glu Trp Gly Ser Trp Ser Leu Cys Ser Arg Ser Cys 
        355                 360                 365             


Gly Arg Gly Ser Arg Ser Arg Met Arg Thr Cys Val Pro Pro Gln His 
    370                 375                 380                 


Gly Gly Lys Ala Cys Glu Gly Pro Glu Leu Gln Thr Lys Leu Cys Ser 
385                 390                 395                 400 


Met Ala Ala Cys Pro Val Glu Gly Gln Trp Leu Glu Trp Gly Pro Trp 
                405                 410                 415     


Gly Pro Cys Ser Thr Ser Cys Ala Asn Gly Thr Gln Gln Arg Ser Arg 
            420                 425                 430         


Lys Cys Ser Val Ala Gly Pro Ala Trp Ala Thr Cys Thr Gly Ala Leu 
        435                 440                 445             


Thr Asp Thr Arg Glu Cys Ser Asn Leu Glu Cys Pro Ala Thr Asp Ser 
    450                 455                 460                 


Lys Trp Gly Pro Trp Asn Ala Trp Ser Leu Cys Ser Lys Thr Cys Asp 
465                 470                 475                 480 


Thr Gly Trp Gln Arg Arg Phe Arg Met Cys Gln Ala Thr Gly Thr Gln 
                485                 490                 495     


Gly Tyr Pro Cys Glu Gly Thr Gly Glu Glu Val Lys Pro Cys Ser Glu 
            500                 505                 510         


Lys Arg Cys Pro Ala Phe His Glu Met Cys Arg Asp Glu Tyr Val Met 
        515                 520                 525             


Leu Met Thr Trp Lys Lys Ala Ala Ala Gly Glu Ile Ile Tyr Asn Lys 
    530                 535                 540                 


Cys Pro Pro Asn Ala Ser Gly Ser Ala Ser Arg Arg Cys Leu Leu Ser 
545                 550                 555                 560 


Ala Gln Gly Val Ala Tyr Trp Gly Leu Pro Ser Phe Ala Arg Cys Ile 
                565                 570                 575     


Ser His Glu Tyr Arg Tyr Leu Tyr Leu Ser Leu Arg Glu His Leu Ala 
            580                 585                 590         


Lys Gly Gln Arg Met Leu Ala Gly Glu Gly Met Ser Gln Val Val Arg 
        595                 600                 605             


Ser Leu Gln Glu Leu Leu Ala Arg Arg Thr Tyr Tyr Ser Gly Asp Leu 
    610                 615                 620                 


Leu Phe Ser Val Asp Ile Leu Arg Asn Val Thr Asp Thr Phe Lys Arg 
625                 630                 635                 640 


Ala Thr Tyr Val Pro Ser Ala Asp Asp Val Gln Arg Phe Phe Gln Val 
                645                 650                 655     


Val Ser Phe Met Val Asp Ala Glu Asn Lys Glu Lys Trp Asp Asp Ala 
            660                 665                 670         


Gln Gln Val Ser Pro Gly Ser Val His Leu Leu Arg Val Val Glu Asp 
        675                 680                 685             


Phe Ile His Leu Val Gly Asp Ala Leu Lys Ala Phe Gln Ser Ser Leu 
    690                 695                 700                 


Ile Val Thr Asp Asn Leu Val Ile Ser Ile Gln Arg Glu Pro Val Ser 
705                 710                 715                 720 


Ala Val Ser Ser Asp Ile Thr Phe Pro Met Arg Gly Arg Arg Gly Met 
                725                 730                 735     


Lys Asp Trp Val Arg His Ser Glu Asp Arg Leu Phe Leu Pro Lys Glu 
            740                 745                 750         


Val Leu Ser Leu Ser Ser Pro Gly Lys Pro Ala Thr Ser Gly Ala Ala 
        755                 760                 765             


Gly Ser Pro Gly Arg Gly Arg Gly Pro Gly Thr Val Pro Pro Gly Pro 
    770                 775                 780                 


Gly His Ser His Gln Arg Leu Leu Pro Ala Asp Pro Asp Glu Ser Ser 
785                 790                 795                 800 


Tyr Phe Val Ile Gly Ala Val Leu Tyr Arg Thr Leu Gly Leu Ile Leu 
                805                 810                 815     


Pro Pro Pro Arg Pro Pro Leu Ala Val Thr Ser Arg Val Met Thr Val 
            820                 825                 830         


Thr Val Arg Pro Pro Thr Gln Pro Pro Ala Glu Pro Leu Ile Thr Val 
        835                 840                 845             


Glu Leu Ser Tyr Ile Ile Asn Gly Thr Thr Asp Pro His Cys Ala Ser 
    850                 855                 860                 


Trp Asp Tyr Ser Arg Ala Asp Ala Ser Ser Gly Asp Trp Asp Thr Glu 
865                 870                 875                 880 


Asn Cys Gln Thr Leu Glu Thr Gln Ala Ala His Thr Arg Cys Gln Cys 
                885                 890                 895     


Gln His Leu Ser Thr Phe Ala Val Leu Ala Gln Pro Pro Lys Asp Leu 
            900                 905                 910         


Thr Leu Glu Leu Ala Gly Ser Pro Ser Val Pro Leu Val Ile Gly Cys 
        915                 920                 925             


Ala Val Ser Cys Met Ala Leu Leu Thr Leu Leu Ala Ile Tyr Ala Ala 
    930                 935                 940                 


Phe Trp Arg Phe Ile Lys Ser Glu Arg Ser Ile Ile Leu Leu Asn Phe 
945                 950                 955                 960 


Cys Leu Ser Ile Leu Ala Ser Asn Ile Leu Ile Leu Val Gly Gln Ser 
                965                 970                 975     


Arg Val Leu Ser Lys Gly Val Cys Thr Met Thr Ala Ala Phe Leu His 
            980                 985                 990         


Phe Phe Phe Leu Ser Ser Phe Cys  Trp Val Leu Thr Glu  Ala Trp Gln 
        995                 1000                 1005             


Ser Tyr  Leu Ala Val Ile Gly  Arg Met Arg Thr Arg  Leu Val Arg 
    1010                 1015                 1020             


Lys Arg  Phe Leu Cys Leu Gly  Trp Gly Leu Pro Ala  Leu Val Val 
    1025                 1030                 1035             


Ala Val  Ser Val Gly Phe Thr  Arg Thr Lys Gly Tyr  Gly Thr Ser 
    1040                 1045                 1050             


Ser Tyr  Cys Trp Leu Ser Leu  Glu Gly Gly Leu Leu  Tyr Ala Phe 
    1055                 1060                 1065             


Val Gly  Pro Ala Ala Val Ile  Val Leu Val Asn Met  Leu Ile Gly 
    1070                 1075                 1080             


Ile Ile  Val Phe Asn Lys Leu  Met Ala Arg Asp Gly  Ile Ser Asp 
    1085                 1090                 1095             


Lys Ser  Lys Lys Gln Arg Ala  Gly Ser Glu Arg Cys  Pro Trp Ala 
    1100                 1105                 1110             


Ser Leu  Leu Leu Pro Cys Ser  Ala Cys Gly Ala Val  Pro Ser Pro 
    1115                 1120                 1125             


Leu Leu  Ser Ser Ala Ser Ala  Arg Asn Ala Met Ala  Ser Leu Trp 
    1130                 1135                 1140             


Ser Ser  Cys Val Val Leu Pro  Leu Leu Ala Leu Thr  Trp Met Ser 
    1145                 1150                 1155             


Ala Val  Leu Ala Met Thr Asp  Arg Arg Ser Val Leu  Phe Gln Ala 
    1160                 1165                 1170             


Leu Phe  Ala Val Phe Asn Ser  Ala Gln Gly Phe Val  Ile Thr Ala 
    1175                 1180                 1185             


Val His  Cys Phe Leu Arg Arg  Glu Val Gln Asp Val  Val Lys Cys 
    1190                 1195                 1200             


Gln Met  Gly Val Cys Arg Ala  Asp Glu Ser Glu Asp  Ser Pro Asp 
    1205                 1210                 1215             


Ser Cys  Lys Asn Gly Gln Leu  Gln Ile Leu Ser Asp  Phe Glu Lys 
    1220                 1225                 1230             


Asp Val  Asp Leu Ala Cys Gln  Thr Val Leu Phe Lys  Glu Val Asn 
    1235                 1240                 1245             


Thr Cys  Asn Pro Ser Thr Ile  Thr Gly Thr Leu Ser  Arg Leu Ser 
    1250                 1255                 1260             


Leu Asp  Glu Asp Glu Glu Pro  Lys Ser Cys Leu Val  Gly Pro Glu 
    1265                 1270                 1275             


Gly Ser  Leu Ser Phe Ser Pro  Leu Pro Gly Asn Ile  Leu Val Pro 
    1280                 1285                 1290             


Met Ala  Ala Ser Pro Gly Leu  Gly Glu Pro Pro Pro  Pro Gln Glu 
    1295                 1300                 1305             


Ala Asn  Pro Val Tyr Met Cys  Gly Glu Gly Gly Leu  Arg Gln Leu 
    1310                 1315                 1320             


Asp Leu  Thr Trp Leu Arg Pro  Thr Glu Pro Gly Ser  Glu Gly Asp 
    1325                 1330                 1335             


Tyr Met  Val Leu Pro Arg Arg  Thr Leu Ser Leu Gln  Pro Gly Gly 
    1340                 1345                 1350             


Gly Gly  Gly Gly Gly Glu Asp  Ala Pro Arg Ala Arg  Pro Glu Gly 
    1355                 1360                 1365             


Thr Pro  Arg Arg Ala Ala Lys  Thr Val Ala His Thr  Glu Gly Tyr 
    1370                 1375                 1380             


Pro Ser  Phe Leu Ser Val Asp  His Ser Gly Leu Gly  Leu Gly Pro 
    1385                 1390                 1395             


Ala Tyr  Gly Ser Leu Gln Asn  Pro Tyr Gly Met Thr  Phe Gln Pro 
    1400                 1405                 1410             


Pro Pro  Pro Thr Pro Ser Ala  Arg Gln Val Pro Glu  Pro Gly Glu 
    1415                 1420                 1425             


Arg Ser  Arg Thr Met Pro Arg  Thr Val Pro Gly Ser  Thr Met Lys 
    1430                 1435                 1440             


Met Gly  Ser Leu Glu Arg Lys  Lys Leu Arg Tyr Ser  Asp Leu Asp 
    1445                 1450                 1455             


Phe Glu  Lys Val Met His Thr  Arg Lys Arg His Ser  Glu Leu Tyr 
    1460                 1465                 1470             


His Glu  Leu Asn Gln Lys Phe  His Thr Phe Asp Arg  Tyr Arg Ser 
    1475                 1480                 1485             


Gln Ser  Thr Ala Lys Asp Lys  Pro Ser Pro Gly Glu  Arg Pro Ser 
    1490                 1495                 1500             


Leu Ser  Gln His Arg Arg His  Gln Ser Trp Ser Thr  Phe Lys Ser 
    1505                 1510                 1515             


Met Thr  Leu Gly Ser Leu Pro  Pro Lys Pro Arg Glu  Arg Leu Thr 
    1520                 1525                 1530             


Leu His  Arg Ala Ala Ala Trp  Glu Pro Thr Glu Pro  Pro Asp Gly 
    1535                 1540                 1545             


Asp Phe  Gln Thr Glu Val 
    1550                 


<210>  424
<211>  1499
<212>  PRT
<213>  Homo Sapiens

<400>  424

Met Thr Pro Ala Cys Pro Leu Leu Leu Ser Val Ile Leu Ser Leu Arg 
1               5                   10                  15      


Leu Ala Thr Ala Phe Asp Pro Ala Pro Ser Ala Cys Ser Ala Leu Ala 
            20                  25                  30          


Ser Gly Val Leu Tyr Gly Ala Phe Ser Leu Gln Asp Leu Phe Pro Thr 
        35                  40                  45              


Ile Ala Ser Gly Cys Ser Trp Thr Leu Glu Asn Pro Asp Pro Thr Lys 
    50                  55                  60                  


Tyr Ser Leu Tyr Leu Arg Phe Asn Arg Gln Glu Gln Val Cys Ala His 
65                  70                  75                  80  


Phe Ala Pro Arg Leu Leu Pro Leu Asp His Tyr Leu Val Asn Phe Thr 
                85                  90                  95      


Cys Leu Arg Pro Ser Pro Glu Glu Ala Val Ala Gln Ala Glu Ser Glu 
            100                 105                 110         


Val Gly Arg Pro Glu Glu Glu Glu Ala Glu Ala Ala Ala Gly Leu Glu 
        115                 120                 125             


Leu Cys Ser Gly Ser Gly Pro Phe Thr Phe Leu His Phe Asp Lys Asn 
    130                 135                 140                 


Phe Val Gln Leu Cys Leu Ser Ala Glu Pro Ser Glu Ala Pro Arg Leu 
145                 150                 155                 160 


Leu Ala Pro Ala Ala Leu Ala Phe Arg Phe Val Glu Val Leu Leu Ile 
                165                 170                 175     


Asn Asn Asn Asn Ser Ser Gln Phe Thr Cys Gly Val Leu Cys Arg Trp 
            180                 185                 190         


Ser Glu Glu Cys Gly Arg Ala Ala Gly Arg Ala Cys Gly Phe Ala Gln 
        195                 200                 205             


Pro Gly Cys Ser Cys Pro Gly Glu Ala Gly Ala Gly Ser Thr Thr Thr 
    210                 215                 220                 


Thr Ser Pro Gly Pro Pro Ala Ala His Thr Leu Ser Asn Ala Leu Val 
225                 230                 235                 240 


Pro Gly Gly Pro Ala Pro Pro Ala Glu Ala Asp Leu His Ser Gly Ser 
                245                 250                 255     


Ser Asn Asp Leu Phe Thr Thr Glu Met Arg Tyr Gly Glu Glu Pro Glu 
            260                 265                 270         


Glu Glu Pro Lys Val Lys Thr Gln Trp Pro Arg Ser Ala Asp Glu Pro 
        275                 280                 285             


Gly Leu Tyr Met Ala Gln Thr Val His Gly Val Trp Glu Glu Trp Gly 
    290                 295                 300                 


Ser Trp Ser Leu Cys Ser Arg Ser Cys Gly Arg Gly Ser Arg Ser Arg 
305                 310                 315                 320 


Met Arg Thr Cys Val Pro Pro Gln His Gly Gly Lys Ala Cys Glu Gly 
                325                 330                 335     


Pro Glu Leu Gln Thr Lys Leu Cys Ser Met Ala Ala Cys Pro Val Glu 
            340                 345                 350         


Gly Gln Trp Leu Glu Trp Gly Pro Trp Gly Pro Cys Ser Thr Ser Cys 
        355                 360                 365             


Ala Asn Gly Thr Gln Gln Arg Ser Arg Lys Cys Ser Val Ala Gly Pro 
    370                 375                 380                 


Ala Trp Ala Thr Cys Thr Gly Ala Leu Thr Asp Thr Arg Glu Cys Ser 
385                 390                 395                 400 


Asn Leu Glu Cys Pro Ala Thr Asp Ser Lys Trp Gly Pro Trp Asn Ala 
                405                 410                 415     


Trp Ser Leu Cys Ser Lys Thr Cys Asp Thr Gly Trp Gln Arg Arg Phe 
            420                 425                 430         


Arg Met Cys Gln Ala Thr Gly Thr Gln Gly Tyr Pro Cys Glu Gly Thr 
        435                 440                 445             


Gly Glu Glu Val Lys Pro Cys Ser Glu Lys Arg Cys Pro Ala Phe His 
    450                 455                 460                 


Glu Met Cys Arg Asp Glu Tyr Val Met Leu Met Thr Trp Lys Lys Ala 
465                 470                 475                 480 


Ala Ala Gly Glu Ile Ile Tyr Asn Lys Cys Pro Pro Asn Ala Ser Gly 
                485                 490                 495     


Ser Ala Ser Arg Arg Cys Leu Leu Ser Ala Gln Gly Val Ala Tyr Trp 
            500                 505                 510         


Gly Leu Pro Ser Phe Ala Arg Cys Ile Ser His Glu Tyr Arg Tyr Leu 
        515                 520                 525             


Tyr Leu Ser Leu Arg Glu His Leu Ala Lys Gly Gln Arg Met Leu Ala 
    530                 535                 540                 


Gly Glu Gly Met Ser Gln Val Val Arg Ser Leu Gln Glu Leu Leu Ala 
545                 550                 555                 560 


Arg Arg Thr Tyr Tyr Ser Gly Asp Leu Leu Phe Ser Val Asp Ile Leu 
                565                 570                 575     


Arg Asn Val Thr Asp Thr Phe Lys Arg Ala Thr Tyr Val Pro Ser Ala 
            580                 585                 590         


Asp Asp Val Gln Arg Phe Phe Gln Val Val Ser Phe Met Val Asp Ala 
        595                 600                 605             


Glu Asn Lys Glu Lys Trp Asp Asp Ala Gln Gln Val Ser Pro Gly Ser 
    610                 615                 620                 


Val His Leu Leu Arg Val Val Glu Asp Phe Ile His Leu Val Gly Asp 
625                 630                 635                 640 


Ala Leu Lys Ala Phe Gln Ser Ser Leu Ile Val Thr Asp Asn Leu Val 
                645                 650                 655     


Ile Ser Ile Gln Arg Glu Pro Val Ser Ala Val Ser Ser Asp Ile Thr 
            660                 665                 670         


Phe Pro Met Arg Gly Arg Arg Gly Met Lys Asp Trp Val Arg His Ser 
        675                 680                 685             


Glu Asp Arg Leu Phe Leu Pro Lys Glu Val Leu Ser Leu Ser Ser Pro 
    690                 695                 700                 


Gly Lys Pro Ala Thr Ser Gly Ala Ala Gly Ser Pro Gly Arg Gly Arg 
705                 710                 715                 720 


Gly Pro Gly Thr Val Pro Pro Gly Pro Gly His Ser His Gln Arg Leu 
                725                 730                 735     


Leu Pro Ala Asp Pro Asp Glu Ser Ser Tyr Phe Val Ile Gly Ala Val 
            740                 745                 750         


Leu Tyr Arg Thr Leu Gly Leu Ile Leu Pro Pro Pro Arg Pro Pro Leu 
        755                 760                 765             


Ala Val Thr Ser Arg Val Met Thr Val Thr Val Arg Pro Pro Thr Gln 
    770                 775                 780                 


Pro Pro Ala Glu Pro Leu Ile Thr Val Glu Leu Ser Tyr Ile Ile Asn 
785                 790                 795                 800 


Gly Thr Thr Asp Pro His Cys Ala Ser Trp Asp Tyr Ser Arg Ala Asp 
                805                 810                 815     


Ala Ser Ser Gly Asp Trp Asp Thr Glu Asn Cys Gln Thr Leu Glu Thr 
            820                 825                 830         


Gln Ala Ala His Thr Arg Cys Gln Cys Gln His Leu Ser Thr Phe Ala 
        835                 840                 845             


Val Leu Ala Gln Pro Pro Lys Asp Leu Thr Leu Glu Leu Ala Gly Ser 
    850                 855                 860                 


Pro Ser Val Pro Leu Val Ile Gly Cys Ala Val Ser Cys Met Ala Leu 
865                 870                 875                 880 


Leu Thr Leu Leu Ala Ile Tyr Ala Ala Phe Trp Arg Phe Ile Lys Ser 
                885                 890                 895     


Glu Arg Ser Ile Ile Leu Leu Asn Phe Cys Leu Ser Ile Leu Ala Ser 
            900                 905                 910         


Asn Ile Leu Ile Leu Val Gly Gln Ser Arg Val Leu Ser Lys Gly Val 
        915                 920                 925             


Cys Thr Met Thr Ala Ala Phe Leu His Phe Phe Phe Leu Ser Ser Phe 
    930                 935                 940                 


Cys Trp Val Leu Thr Glu Ala Trp Gln Ser Tyr Leu Ala Val Ile Gly 
945                 950                 955                 960 


Arg Met Arg Thr Arg Leu Val Arg Lys Arg Phe Leu Cys Leu Gly Trp 
                965                 970                 975     


Gly Leu Pro Ala Leu Val Val Ala Val Ser Val Gly Phe Thr Arg Thr 
            980                 985                 990         


Lys Gly Tyr Gly Thr Ser Ser Tyr  Cys Trp Leu Ser Leu  Glu Gly Gly 
        995                 1000                 1005             


Leu Leu  Tyr Ala Phe Val Gly  Pro Ala Ala Val Ile  Val Leu Val 
    1010                 1015                 1020             


Asn Met  Leu Ile Gly Ile Ile  Val Phe Asn Lys Leu  Met Ala Arg 
    1025                 1030                 1035             


Asp Gly  Ile Ser Asp Lys Ser  Lys Lys Gln Arg Ala  Gly Ser Glu 
    1040                 1045                 1050             


Arg Cys  Pro Trp Ala Ser Leu  Leu Leu Pro Cys Ser  Ala Cys Gly 
    1055                 1060                 1065             


Ala Val  Pro Ser Pro Leu Leu  Ser Ser Ala Ser Ala  Arg Asn Ala 
    1070                 1075                 1080             


Met Ala  Ser Leu Trp Ser Ser  Cys Val Val Leu Pro  Leu Leu Ala 
    1085                 1090                 1095             


Leu Thr  Trp Met Ser Ala Val  Leu Ala Met Thr Asp  Arg Arg Ser 
    1100                 1105                 1110             


Val Leu  Phe Gln Ala Leu Phe  Ala Val Phe Asn Ser  Ala Gln Gly 
    1115                 1120                 1125             


Phe Val  Ile Thr Ala Val His  Cys Phe Leu Arg Arg  Glu Val Gln 
    1130                 1135                 1140             


Asp Val  Val Lys Cys Gln Met  Gly Val Cys Arg Ala  Asp Glu Ser 
    1145                 1150                 1155             


Glu Asp  Ser Pro Asp Ser Cys  Lys Asn Gly Gln Leu  Gln Ile Leu 
    1160                 1165                 1170             


Ser Asp  Phe Glu Lys Asp Val  Asp Leu Ala Cys Gln  Thr Val Leu 
    1175                 1180                 1185             


Phe Lys  Glu Val Asn Thr Cys  Asn Pro Ser Thr Ile  Thr Gly Thr 
    1190                 1195                 1200             


Leu Ser  Arg Leu Ser Leu Asp  Glu Asp Glu Glu Pro  Lys Ser Cys 
    1205                 1210                 1215             


Leu Val  Gly Pro Glu Gly Ser  Leu Ser Phe Ser Pro  Leu Pro Gly 
    1220                 1225                 1230             


Asn Ile  Leu Val Pro Met Ala  Ala Ser Pro Gly Leu  Gly Glu Pro 
    1235                 1240                 1245             


Pro Pro  Pro Gln Glu Ala Asn  Pro Val Tyr Met Cys  Gly Glu Gly 
    1250                 1255                 1260             


Gly Leu  Arg Gln Leu Asp Leu  Thr Trp Leu Arg Pro  Thr Glu Pro 
    1265                 1270                 1275             


Gly Ser  Glu Gly Asp Tyr Met  Val Leu Pro Arg Arg  Thr Leu Ser 
    1280                 1285                 1290             


Leu Gln  Pro Gly Gly Gly Gly  Gly Gly Gly Glu Asp  Ala Pro Arg 
    1295                 1300                 1305             


Ala Arg  Pro Glu Gly Thr Pro  Arg Arg Ala Ala Lys  Thr Val Ala 
    1310                 1315                 1320             


His Thr  Glu Gly Tyr Pro Ser  Phe Leu Ser Val Asp  His Ser Gly 
    1325                 1330                 1335             


Leu Gly  Leu Gly Pro Ala Tyr  Gly Ser Leu Gln Asn  Pro Tyr Gly 
    1340                 1345                 1350             


Met Thr  Phe Gln Pro Pro Pro  Pro Thr Pro Ser Ala  Arg Gln Val 
    1355                 1360                 1365             


Pro Glu  Pro Gly Glu Arg Ser  Arg Thr Met Pro Arg  Thr Val Pro 
    1370                 1375                 1380             


Gly Ser  Thr Met Lys Met Gly  Ser Leu Glu Arg Lys  Lys Leu Arg 
    1385                 1390                 1395             


Tyr Ser  Asp Leu Asp Phe Glu  Lys Val Met His Thr  Arg Lys Arg 
    1400                 1405                 1410             


His Ser  Glu Leu Tyr His Glu  Leu Asn Gln Lys Phe  His Thr Phe 
    1415                 1420                 1425             


Asp Arg  Tyr Arg Ser Gln Ser  Thr Ala Lys Asp Lys  Pro Ser Pro 
    1430                 1435                 1440             


Gly Glu  Arg Pro Ser Leu Ser  Gln His Arg Arg His  Gln Ser Trp 
    1445                 1450                 1455             


Ser Thr  Phe Lys Ser Met Thr  Leu Gly Ser Leu Pro  Pro Lys Pro 
    1460                 1465                 1470             


Arg Glu  Arg Leu Thr Leu His  Arg Ala Ala Ala Trp  Glu Pro Thr 
    1475                 1480                 1485             


Glu Pro  Pro Asp Gly Asp Phe  Gln Thr Glu Val 
    1490                 1495                 


<210>  425
<211>  1466
<212>  PRT
<213>  Homo Sapiens

<400>  425

Met Thr Pro Ala Cys Pro Leu Leu Leu Ser Val Ile Leu Ser Leu Arg 
1               5                   10                  15      


Leu Ala Thr Ala Phe Asp Pro Ala Pro Ser Ala Cys Ser Ala Leu Ala 
            20                  25                  30          


Ser Gly Val Leu Tyr Gly Ala Phe Ser Leu Gln Asp Leu Phe Pro Thr 
        35                  40                  45              


Ile Ala Ser Gly Cys Ser Trp Thr Leu Glu Asn Pro Asp Pro Thr Lys 
    50                  55                  60                  


Tyr Ser Leu Tyr Leu Arg Phe Asn Arg Gln Glu Gln Val Cys Ala His 
65                  70                  75                  80  


Phe Ala Pro Arg Leu Leu Pro Leu Asp His Tyr Leu Val Asn Phe Thr 
                85                  90                  95      


Cys Leu Arg Pro Ser Pro Glu Glu Ala Val Ala Gln Ala Glu Ser Glu 
            100                 105                 110         


Val Gly Arg Pro Glu Glu Glu Glu Ala Glu Ala Ala Ala Gly Leu Glu 
        115                 120                 125             


Leu Cys Ser Gly Ser Gly Pro Phe Thr Phe Leu His Phe Asp Lys Asn 
    130                 135                 140                 


Phe Val Gln Leu Cys Leu Ser Ala Glu Pro Ser Glu Ala Pro Arg Leu 
145                 150                 155                 160 


Leu Ala Pro Ala Ala Leu Ala Phe Arg Phe Val Glu Val Leu Leu Ile 
                165                 170                 175     


Asn Asn Asn Asn Ser Ser Gln Phe Thr Cys Gly Val Leu Cys Arg Trp 
            180                 185                 190         


Ser Glu Glu Cys Gly Arg Ala Ala Gly Arg Ala Cys Gly Phe Ala Gln 
        195                 200                 205             


Pro Gly Cys Ser Cys Pro Gly Glu Ala Gly Ala Gly Ser Thr Thr Thr 
    210                 215                 220                 


Thr Ser Pro Gly Pro Pro Ala Ala His Thr Leu Ser Asn Ala Leu Val 
225                 230                 235                 240 


Pro Gly Gly Pro Ala Pro Pro Ala Glu Ala Asp Leu His Ser Gly Ser 
                245                 250                 255     


Ser Asn Asp Leu Phe Thr Thr Glu Met Arg Tyr Gly Glu Glu Pro Glu 
            260                 265                 270         


Glu Glu Pro Lys Val Lys Thr Gln Trp Pro Arg Ser Ala Asp Glu Pro 
        275                 280                 285             


Gly Leu Tyr Met Ala Gln Thr Gly Asp Pro Ala Ala Glu Glu Trp Ser 
    290                 295                 300                 


Pro Trp Ser Val Cys Ser Leu Thr Cys Gly Gln Gly Leu Gln Val Arg 
305                 310                 315                 320 


Thr Arg Ser Cys Val Ser Ser Pro Tyr Gly Thr Leu Cys Ser Gly Pro 
                325                 330                 335     


Leu Arg Glu Thr Arg Pro Cys Asn Asn Ser Ala Thr Cys Pro Val Glu 
            340                 345                 350         


Gly Gln Trp Leu Glu Trp Gly Pro Trp Gly Pro Cys Ser Thr Ser Cys 
        355                 360                 365             


Ala Asn Gly Thr Gln Gln Arg Ser Arg Lys Cys Ser Val Ala Gly Pro 
    370                 375                 380                 


Ala Trp Ala Thr Cys Thr Gly Ala Leu Thr Asp Thr Arg Glu Cys Ser 
385                 390                 395                 400 


Asn Leu Glu Cys Pro Ala Thr Asp Ser Lys Trp Gly Pro Trp Asn Ala 
                405                 410                 415     


Trp Ser Leu Cys Ser Lys Thr Cys Asp Thr Gly Trp Gln Arg Arg Phe 
            420                 425                 430         


Arg Met Cys Gln Ala Thr Gly Thr Gln Gly Tyr Pro Cys Glu Gly Thr 
        435                 440                 445             


Gly Glu Glu Val Lys Pro Cys Ser Glu Lys Arg Cys Pro Ala Phe His 
    450                 455                 460                 


Glu Met Cys Arg Asp Glu Tyr Val Met Leu Met Thr Trp Lys Lys Ala 
465                 470                 475                 480 


Ala Ala Gly Glu Ile Ile Tyr Asn Lys Cys Pro Pro Asn Ala Ser Gly 
                485                 490                 495     


Ser Ala Ser Arg Arg Cys Leu Leu Ser Ala Gln Gly Val Ala Tyr Trp 
            500                 505                 510         


Gly Leu Pro Ser Phe Ala Arg Cys Ile Ser His Glu Tyr Arg Tyr Leu 
        515                 520                 525             


Tyr Leu Ser Leu Arg Glu His Leu Ala Lys Gly Gln Arg Met Leu Ala 
    530                 535                 540                 


Gly Glu Gly Met Ser Gln Val Val Arg Ser Leu Gln Glu Leu Leu Ala 
545                 550                 555                 560 


Arg Arg Thr Tyr Tyr Ser Gly Asp Leu Leu Phe Ser Val Asp Ile Leu 
                565                 570                 575     


Arg Asn Val Thr Asp Thr Phe Lys Arg Ala Thr Tyr Val Pro Ser Ala 
            580                 585                 590         


Asp Asp Val Gln Arg Phe Phe Gln Val Val Ser Phe Met Val Asp Ala 
        595                 600                 605             


Glu Asn Lys Glu Lys Trp Asp Asp Ala Gln Gln Val Ser Pro Gly Ser 
    610                 615                 620                 


Val His Leu Leu Arg Val Val Glu Asp Phe Ile His Leu Val Gly Asp 
625                 630                 635                 640 


Ala Leu Lys Ala Phe Gln Ser Ser Leu Ile Val Thr Asp Asn Leu Val 
                645                 650                 655     


Ile Ser Ile Gln Arg Glu Pro Val Ser Ala Val Ser Ser Asp Ile Thr 
            660                 665                 670         


Phe Pro Met Arg Gly Arg Arg Gly Met Lys Asp Trp Val Arg His Ser 
        675                 680                 685             


Glu Asp Arg Leu Phe Leu Pro Lys Glu Val Leu Ser Leu Ser Ser Pro 
    690                 695                 700                 


Gly Lys Pro Ala Thr Ser Gly Ala Ala Gly Ser Pro Gly Arg Gly Arg 
705                 710                 715                 720 


Gly Pro Gly Thr Val Pro Pro Gly Pro Gly His Ser His Gln Arg Leu 
                725                 730                 735     


Leu Pro Ala Asp Pro Asp Glu Ser Ser Tyr Phe Val Ile Gly Ala Val 
            740                 745                 750         


Leu Tyr Arg Thr Leu Gly Leu Ile Leu Pro Pro Pro Arg Pro Pro Leu 
        755                 760                 765             


Ala Val Thr Ser Arg Val Met Thr Val Thr Val Arg Pro Pro Thr Gln 
    770                 775                 780                 


Pro Pro Ala Glu Pro Leu Ile Thr Val Glu Leu Ser Tyr Ile Ile Asn 
785                 790                 795                 800 


Gly Thr Thr Asp Pro His Cys Ala Ser Trp Asp Tyr Ser Arg Ala Asp 
                805                 810                 815     


Ala Ser Ser Gly Asp Trp Asp Thr Glu Asn Cys Gln Thr Leu Glu Thr 
            820                 825                 830         


Gln Ala Ala His Thr Arg Cys Gln Cys Gln His Leu Ser Thr Phe Ala 
        835                 840                 845             


Val Leu Ala Gln Pro Pro Lys Asp Leu Thr Leu Glu Leu Ala Gly Ser 
    850                 855                 860                 


Pro Ser Val Pro Leu Val Ile Gly Cys Ala Val Ser Cys Met Ala Leu 
865                 870                 875                 880 


Leu Thr Leu Leu Ala Ile Tyr Ala Ala Phe Trp Arg Phe Ile Lys Ser 
                885                 890                 895     


Glu Arg Ser Ile Ile Leu Leu Asn Phe Cys Leu Ser Ile Leu Ala Ser 
            900                 905                 910         


Asn Ile Leu Ile Leu Val Gly Gln Ser Arg Val Leu Ser Lys Gly Val 
        915                 920                 925             


Cys Thr Met Thr Ala Ala Phe Leu His Phe Phe Phe Leu Ser Ser Phe 
    930                 935                 940                 


Cys Trp Val Leu Thr Glu Ala Trp Gln Ser Tyr Leu Ala Val Ile Gly 
945                 950                 955                 960 


Arg Met Arg Thr Arg Leu Val Arg Lys Arg Phe Leu Cys Leu Gly Trp 
                965                 970                 975     


Gly Leu Pro Ala Leu Val Val Ala Val Ser Val Gly Phe Thr Arg Thr 
            980                 985                 990         


Lys Gly Tyr Gly Thr Ser Ser Tyr  Cys Trp Leu Ser Leu  Glu Gly Gly 
        995                 1000                 1005             


Leu Leu  Tyr Ala Phe Val Gly  Pro Ala Ala Val Ile  Val Leu Val 
    1010                 1015                 1020             


Asn Met  Leu Ile Gly Ile Ile  Val Phe Asn Lys Leu  Met Ala Arg 
    1025                 1030                 1035             


Asp Gly  Ile Ser Asp Lys Ser  Lys Lys Gln Arg Ala  Gly Ala Ser 
    1040                 1045                 1050             


Leu Trp  Ser Ser Cys Val Val  Leu Pro Leu Leu Ala  Leu Thr Trp 
    1055                 1060                 1065             


Met Ser  Ala Val Leu Ala Met  Thr Asp Arg Arg Ser  Val Leu Phe 
    1070                 1075                 1080             


Gln Ala  Leu Phe Ala Val Phe  Asn Ser Ala Gln Gly  Phe Val Ile 
    1085                 1090                 1095             


Thr Ala  Val His Cys Phe Leu  Arg Arg Glu Val Gln  Asp Val Val 
    1100                 1105                 1110             


Lys Cys  Gln Met Gly Val Cys  Arg Ala Asp Glu Ser  Glu Asp Ser 
    1115                 1120                 1125             


Pro Asp  Ser Cys Lys Asn Gly  Gln Leu Gln Ile Leu  Ser Asp Phe 
    1130                 1135                 1140             


Glu Lys  Asp Val Asp Leu Ala  Cys Gln Thr Val Leu  Phe Lys Glu 
    1145                 1150                 1155             


Val Asn  Thr Cys Asn Pro Ser  Thr Ile Thr Gly Thr  Leu Ser Arg 
    1160                 1165                 1170             


Leu Ser  Leu Asp Glu Asp Glu  Glu Pro Lys Ser Cys  Leu Val Gly 
    1175                 1180                 1185             


Pro Glu  Gly Ser Leu Ser Phe  Ser Pro Leu Pro Gly  Asn Ile Leu 
    1190                 1195                 1200             


Val Pro  Met Ala Ala Ser Pro  Gly Leu Gly Glu Pro  Pro Pro Pro 
    1205                 1210                 1215             


Gln Glu  Ala Asn Pro Val Tyr  Met Cys Gly Glu Gly  Gly Leu Arg 
    1220                 1225                 1230             


Gln Leu  Asp Leu Thr Trp Leu  Arg Pro Thr Glu Pro  Gly Ser Glu 
    1235                 1240                 1245             


Gly Asp  Tyr Met Val Leu Pro  Arg Arg Thr Leu Ser  Leu Gln Pro 
    1250                 1255                 1260             


Gly Gly  Gly Gly Gly Gly Gly  Glu Asp Ala Pro Arg  Ala Arg Pro 
    1265                 1270                 1275             


Glu Gly  Thr Pro Arg Arg Ala  Ala Lys Thr Val Ala  His Thr Glu 
    1280                 1285                 1290             


Gly Tyr  Pro Ser Phe Leu Ser  Val Asp His Ser Gly  Leu Gly Leu 
    1295                 1300                 1305             


Gly Pro  Ala Tyr Gly Ser Leu  Gln Asn Pro Tyr Gly  Met Thr Phe 
    1310                 1315                 1320             


Gln Pro  Pro Pro Pro Thr Pro  Ser Ala Arg Gln Val  Pro Glu Pro 
    1325                 1330                 1335             


Gly Glu  Arg Ser Arg Thr Met  Pro Arg Thr Val Pro  Gly Ser Thr 
    1340                 1345                 1350             


Met Lys  Met Gly Ser Leu Glu  Arg Lys Lys Leu Arg  Tyr Ser Asp 
    1355                 1360                 1365             


Leu Asp  Phe Glu Lys Val Met  His Thr Arg Lys Arg  His Ser Glu 
    1370                 1375                 1380             


Leu Tyr  His Glu Leu Asn Gln  Lys Phe His Thr Phe  Asp Arg Tyr 
    1385                 1390                 1395             


Arg Ser  Gln Ser Thr Ala Lys  Asp Lys Pro Ser Pro  Gly Glu Arg 
    1400                 1405                 1410             


Pro Ser  Leu Ser Gln His Arg  Arg His Gln Ser Trp  Ser Thr Phe 
    1415                 1420                 1425             


Lys Ser  Met Thr Leu Gly Ser  Leu Pro Pro Lys Pro  Arg Glu Arg 
    1430                 1435                 1440             


Leu Thr  Leu His Arg Ala Ala  Ala Trp Glu Pro Thr  Glu Pro Pro 
    1445                 1450                 1455             


Asp Gly  Asp Phe Gln Thr Glu  Val 
    1460                 1465     


<210>  426
<211>  906
<212>  PRT
<213>  Homo Sapiens

<400>  426

Met Glu Lys Leu Leu Arg Leu Cys Cys Trp Tyr Ser Trp Leu Leu Leu 
1               5                   10                  15      


Phe Tyr Tyr Asn Phe Gln Val Arg Gly Val Tyr Ser Arg Ser Gln Asp 
            20                  25                  30          


His Pro Gly Phe Gln Val Leu Ala Ser Ala Ser His Tyr Trp Pro Leu 
        35                  40                  45              


Glu Asn Val Asp Gly Ile His Glu Leu Gln Asp Thr Thr Gly Ala Ser 
    50                  55                  60                  


Arg Thr His Lys Leu Thr Val Leu Pro Ser Arg Asn Ala Thr Phe Val 
65                  70                  75                  80  


Tyr Ser Asn Asp Ser Ala Tyr Ser Asn Leu Ser Ala Thr Val Asp Ile 
                85                  90                  95      


Val Glu Gly Lys Val Asn Lys Gly Ile Tyr Leu Lys Glu Glu Lys Gly 
            100                 105                 110         


Val Thr Leu Leu Tyr Tyr Gly Arg Tyr Asn Ser Ser Cys Ile Ser Lys 
        115                 120                 125             


Pro Glu Gln Cys Gly Pro Glu Gly Val Thr Phe Ser Phe Phe Trp Lys 
    130                 135                 140                 


Thr Gln Gly Glu Gln Ser Arg Pro Ile Pro Ser Ala Tyr Gly Gly Gln 
145                 150                 155                 160 


Val Ile Ser Asn Gly Phe Lys Val Cys Ser Ser Gly Gly Arg Gly Ser 
                165                 170                 175     


Val Glu Leu Tyr Thr Arg Asp Asn Ser Met Thr Trp Glu Ala Ser Phe 
            180                 185                 190         


Ser Pro Pro Gly Pro Tyr Trp Thr His Val Leu Phe Thr Trp Lys Ser 
        195                 200                 205             


Lys Glu Gly Leu Lys Val Tyr Val Asn Gly Thr Leu Ser Thr Ser Asp 
    210                 215                 220                 


Pro Ser Gly Lys Val Ser Arg Asp Tyr Gly Glu Ser Asn Val Asn Leu 
225                 230                 235                 240 


Val Ile Gly Ser Glu Gln Asp Gln Ala Lys Cys Tyr Glu Asn Gly Ala 
                245                 250                 255     


Phe Asp Glu Phe Ile Ile Trp Glu Arg Ala Leu Thr Pro Asp Glu Ile 
            260                 265                 270         


Ala Met Tyr Phe Thr Ala Ala Ile Gly Lys His Ala Leu Leu Ser Ser 
        275                 280                 285             


Thr Leu Pro Ser Leu Phe Met Thr Ser Thr Ala Ser Pro Val Met Pro 
    290                 295                 300                 


Thr Asp Ala Tyr His Pro Ile Ile Thr Asn Leu Thr Glu Glu Arg Lys 
305                 310                 315                 320 


Thr Phe Gln Ser Pro Gly Val Ile Leu Ser Tyr Leu Gln Asn Val Ser 
                325                 330                 335     


Leu Ser Leu Pro Ser Lys Ser Leu Ser Glu Gln Thr Ala Leu Asn Leu 
            340                 345                 350         


Thr Lys Thr Phe Leu Lys Ala Val Gly Glu Ile Leu Leu Leu Pro Gly 
        355                 360                 365             


Trp Ile Ala Leu Ser Glu Asp Ser Ala Val Val Leu Ser Leu Ile Asp 
    370                 375                 380                 


Thr Ile Asp Thr Val Met Gly His Val Ser Ser Asn Leu His Gly Ser 
385                 390                 395                 400 


Thr Pro Gln Val Thr Val Glu Gly Ser Ser Ala Met Ala Glu Phe Ser 
                405                 410                 415     


Val Ala Lys Ile Leu Pro Lys Thr Val Asn Ser Ser His Tyr Arg Phe 
            420                 425                 430         


Pro Ala His Gly Gln Ser Phe Ile Gln Ile Pro His Glu Ala Phe His 
        435                 440                 445             


Arg His Ala Trp Ser Thr Val Val Gly Leu Leu Tyr His Ser Met His 
    450                 455                 460                 


Tyr Tyr Leu Asn Asn Ile Trp Pro Ala His Thr Lys Ile Ala Glu Ala 
465                 470                 475                 480 


Met His His Gln Asp Cys Leu Leu Phe Ala Thr Ser His Leu Ile Ser 
                485                 490                 495     


Leu Glu Val Ser Pro Pro Pro Thr Leu Ser Gln Asn Leu Ser Gly Ser 
            500                 505                 510         


Pro Leu Ile Thr Val His Leu Lys His Arg Leu Thr Arg Lys Gln His 
        515                 520                 525             


Ser Glu Ala Thr Asn Ser Ser Asn Arg Val Phe Val Tyr Cys Ala Phe 
    530                 535                 540                 


Leu Asp Phe Ser Ser Gly Glu Gly Val Trp Ser Asn His Gly Cys Ala 
545                 550                 555                 560 


Leu Thr Arg Gly Asn Leu Thr Tyr Ser Val Cys Arg Cys Thr His Leu 
                565                 570                 575     


Thr Asn Phe Ala Ile Leu Met Gln Val Val Pro Leu Glu Leu Ala Arg 
            580                 585                 590         


Gly His Gln Val Ala Leu Ser Ser Ile Ser Tyr Val Gly Cys Ser Leu 
        595                 600                 605             


Ser Val Leu Cys Leu Val Ala Thr Leu Val Thr Phe Ala Val Leu Ser 
    610                 615                 620                 


Ser Val Ser Thr Ile Arg Asn Gln Arg Tyr His Ile His Ala Asn Leu 
625                 630                 635                 640 


Ser Phe Ala Val Leu Val Ala Gln Val Leu Leu Leu Ile Ser Phe Arg 
                645                 650                 655     


Leu Glu Pro Gly Thr Thr Pro Cys Gln Val Met Ala Val Leu Leu His 
            660                 665                 670         


Tyr Phe Phe Leu Ser Ala Phe Ala Trp Met Leu Val Glu Gly Leu His 
        675                 680                 685             


Leu Tyr Ser Met Val Ile Lys Val Phe Gly Ser Glu Asp Ser Lys His 
    690                 695                 700                 


Arg Tyr Tyr Tyr Gly Met Gly Trp Gly Phe Pro Leu Leu Ile Cys Ile 
705                 710                 715                 720 


Ile Ser Leu Ser Phe Ala Met Asp Ser Tyr Gly Thr Ser Asn Asn Cys 
                725                 730                 735     


Trp Leu Ser Leu Ala Ser Gly Ala Ile Trp Ala Phe Val Ala Pro Ala 
            740                 745                 750         


Leu Phe Val Ile Val Val Asn Ile Gly Ile Leu Ile Ala Val Thr Arg 
        755                 760                 765             


Val Ile Ser Gln Ile Ser Ala Asp Asn Tyr Lys Ile His Gly Asp Pro 
    770                 775                 780                 


Ser Ala Phe Lys Leu Thr Ala Lys Ala Val Ala Val Leu Leu Pro Ile 
785                 790                 795                 800 


Leu Gly Thr Ser Trp Val Phe Gly Val Leu Ala Val Asn Gly Cys Ala 
                805                 810                 815     


Val Val Phe Gln Tyr Met Phe Ala Thr Leu Asn Ser Leu Gln Gly Leu 
            820                 825                 830         


Phe Ile Phe Leu Phe His Cys Leu Leu Asn Ser Glu Val Arg Ala Ala 
        835                 840                 845             


Phe Lys His Lys Thr Lys Val Trp Ser Leu Thr Ser Ser Ser Ala Arg 
    850                 855                 860                 


Thr Ser Asn Ala Lys Pro Phe His Ser Asp Leu Met Asn Gly Thr Arg 
865                 870                 875                 880 


Pro Gly Met Ala Ser Thr Lys Leu Ser Pro Trp Asp Lys Ser Ser His 
                885                 890                 895     


Ser Ala His Arg Val Asp Leu Ser Ala Val 
            900                 905     


<210>  427
<211>  221
<212>  PRT
<213>  Homo Sapiens

<400>  427

Met Glu Lys Leu Leu Arg Leu Cys Cys Trp Tyr Ser Trp Leu Leu Leu 
1               5                   10                  15      


Phe Tyr Tyr Asn Phe Gln Val Arg Gly Val Tyr Ser Arg Ser Gln Asp 
            20                  25                  30          


His Pro Gly Phe Gln Val Leu Ala Ser Ala Ser His Tyr Trp Pro Leu 
        35                  40                  45              


Glu Asn Val Asp Gly Ile His Glu Leu Gln Asp Thr Thr Gly Asp Ile 
    50                  55                  60                  


Val Glu Gly Lys Val Asn Lys Gly Ile Tyr Leu Lys Glu Glu Lys Gly 
65                  70                  75                  80  


Val Thr Leu Leu Tyr Tyr Gly Arg Tyr Asn Ser Ser Cys Ile Ser Lys 
                85                  90                  95      


Pro Glu Gln Cys Gly Pro Glu Gly Pro Tyr Trp Thr His Val Leu Phe 
            100                 105                 110         


Thr Trp Lys Ser Lys Glu Gly Leu Lys Val Tyr Val Asn Gly Thr Leu 
        115                 120                 125             


Ser Thr Ser Asp Pro Ser Gly Lys Val Ser Arg Asp Tyr Gly Glu Ser 
    130                 135                 140                 


Asn Val Asn Leu Val Ile Gly Ser Glu Gln Asp Gln Ala Lys Cys Tyr 
145                 150                 155                 160 


Glu Asn Gly Ala Phe Asp Glu Phe Ile Ile Trp Glu Arg Ala Leu Thr 
                165                 170                 175     


Pro Asp Glu Ile Ala Met Tyr Phe Thr Ala Ala Ile Gly Lys His Ala 
            180                 185                 190         


Leu Leu Ser Ser Thr Leu Pro Ser Leu Phe Met Thr Ser Thr Ala Ser 
        195                 200                 205             


Pro Val Met Pro Thr Asp Ala Tyr His Pro Ile Ile Thr 
    210                 215                 220     


<210>  428
<211>  874
<212>  PRT
<213>  Homo Sapiens

<400>  428

Met Glu Lys Leu Leu Arg Leu Cys Cys Trp Tyr Ser Trp Leu Leu Leu 
1               5                   10                  15      


Phe Tyr Tyr Asn Phe Gln Val Arg Gly Val Tyr Ser Arg Ser Gln Asp 
            20                  25                  30          


His Pro Gly Phe Gln Val Leu Ala Ser Ala Ser His Tyr Trp Pro Leu 
        35                  40                  45              


Glu Asn Val Asp Gly Ile His Glu Leu Gln Asp Thr Thr Gly Asp Ile 
    50                  55                  60                  


Val Glu Gly Lys Val Asn Lys Gly Ile Tyr Leu Lys Glu Glu Lys Gly 
65                  70                  75                  80  


Val Thr Leu Leu Tyr Tyr Gly Arg Tyr Asn Ser Ser Cys Ile Ser Lys 
                85                  90                  95      


Pro Glu Gln Cys Gly Pro Glu Gly Val Thr Phe Ser Phe Phe Trp Lys 
            100                 105                 110         


Thr Gln Gly Glu Gln Ser Arg Pro Ile Pro Ser Ala Tyr Gly Gly Gln 
        115                 120                 125             


Val Ile Ser Asn Gly Phe Lys Val Cys Ser Ser Gly Gly Arg Gly Ser 
    130                 135                 140                 


Val Glu Leu Tyr Thr Arg Asp Asn Ser Met Thr Trp Glu Ala Ser Phe 
145                 150                 155                 160 


Ser Pro Pro Gly Pro Tyr Trp Thr His Val Leu Phe Thr Trp Lys Ser 
                165                 170                 175     


Lys Glu Gly Leu Lys Val Tyr Val Asn Gly Thr Leu Ser Thr Ser Asp 
            180                 185                 190         


Pro Ser Gly Lys Val Ser Arg Asp Tyr Gly Glu Ser Asn Val Asn Leu 
        195                 200                 205             


Val Ile Gly Ser Glu Gln Asp Gln Ala Lys Cys Tyr Glu Asn Gly Ala 
    210                 215                 220                 


Phe Asp Glu Phe Ile Ile Trp Glu Arg Ala Leu Thr Pro Asp Glu Ile 
225                 230                 235                 240 


Ala Met Tyr Phe Thr Ala Ala Ile Gly Lys His Ala Leu Leu Ser Ser 
                245                 250                 255     


Thr Leu Pro Ser Leu Phe Met Thr Ser Thr Ala Ser Pro Val Met Pro 
            260                 265                 270         


Thr Asp Ala Tyr His Pro Ile Ile Thr Asn Leu Thr Glu Glu Arg Lys 
        275                 280                 285             


Thr Phe Gln Ser Pro Gly Val Ile Leu Ser Tyr Leu Gln Asn Val Ser 
    290                 295                 300                 


Leu Ser Leu Pro Ser Lys Ser Leu Ser Glu Gln Thr Ala Leu Asn Leu 
305                 310                 315                 320 


Thr Lys Thr Phe Leu Lys Ala Val Gly Glu Ile Leu Leu Leu Pro Gly 
                325                 330                 335     


Trp Ile Ala Leu Ser Glu Asp Ser Ala Val Val Leu Ser Leu Ile Asp 
            340                 345                 350         


Thr Ile Asp Thr Val Met Gly His Val Ser Ser Asn Leu His Gly Ser 
        355                 360                 365             


Thr Pro Gln Val Thr Val Glu Gly Ser Ser Ala Met Ala Glu Phe Ser 
    370                 375                 380                 


Val Ala Lys Ile Leu Pro Lys Thr Val Asn Ser Ser His Tyr Arg Phe 
385                 390                 395                 400 


Pro Ala His Gly Gln Ser Phe Ile Gln Ile Pro His Glu Ala Phe His 
                405                 410                 415     


Arg His Ala Trp Ser Thr Val Val Gly Leu Leu Tyr His Ser Met His 
            420                 425                 430         


Tyr Tyr Leu Asn Asn Ile Trp Pro Ala His Thr Lys Ile Ala Glu Ala 
        435                 440                 445             


Met His His Gln Asp Cys Leu Leu Phe Ala Thr Ser His Leu Ile Ser 
    450                 455                 460                 


Leu Glu Val Ser Pro Pro Pro Thr Leu Ser Gln Asn Leu Ser Gly Ser 
465                 470                 475                 480 


Pro Leu Ile Thr Val His Leu Lys His Arg Leu Thr Arg Lys Gln His 
                485                 490                 495     


Ser Glu Ala Thr Asn Ser Ser Asn Arg Val Phe Val Tyr Cys Ala Phe 
            500                 505                 510         


Leu Asp Phe Ser Ser Gly Glu Gly Val Trp Ser Asn His Gly Cys Ala 
        515                 520                 525             


Leu Thr Arg Gly Asn Leu Thr Tyr Ser Val Cys Arg Cys Thr His Leu 
    530                 535                 540                 


Thr Asn Phe Ala Ile Leu Met Gln Val Val Pro Leu Glu Leu Ala Arg 
545                 550                 555                 560 


Gly His Gln Val Ala Leu Ser Ser Ile Ser Tyr Val Gly Cys Ser Leu 
                565                 570                 575     


Ser Val Leu Cys Leu Val Ala Thr Leu Val Thr Phe Ala Val Leu Ser 
            580                 585                 590         


Ser Val Ser Thr Ile Arg Asn Gln Arg Tyr His Ile His Ala Asn Leu 
        595                 600                 605             


Ser Phe Ala Val Leu Val Ala Gln Val Leu Leu Leu Ile Ser Phe Arg 
    610                 615                 620                 


Leu Glu Pro Gly Thr Thr Pro Cys Gln Val Met Ala Val Leu Leu His 
625                 630                 635                 640 


Tyr Phe Phe Leu Ser Ala Phe Ala Trp Met Leu Val Glu Gly Leu His 
                645                 650                 655     


Leu Tyr Ser Met Val Ile Lys Val Phe Gly Ser Glu Asp Ser Lys His 
            660                 665                 670         


Arg Tyr Tyr Tyr Gly Met Gly Trp Gly Phe Pro Leu Leu Ile Cys Ile 
        675                 680                 685             


Ile Ser Leu Ser Phe Ala Met Asp Ser Tyr Gly Thr Ser Asn Asn Cys 
    690                 695                 700                 


Trp Leu Ser Leu Ala Ser Gly Ala Ile Trp Ala Phe Val Ala Pro Ala 
705                 710                 715                 720 


Leu Phe Val Ile Val Val Asn Ile Gly Ile Leu Ile Ala Val Thr Arg 
                725                 730                 735     


Val Ile Ser Gln Ile Ser Ala Asp Asn Tyr Lys Ile His Gly Asp Pro 
            740                 745                 750         


Ser Ala Phe Lys Leu Thr Ala Lys Ala Val Ala Val Leu Leu Pro Ile 
        755                 760                 765             


Leu Gly Thr Ser Trp Val Phe Gly Val Leu Ala Val Asn Gly Cys Ala 
    770                 775                 780                 


Val Val Phe Gln Tyr Met Phe Ala Thr Leu Asn Ser Leu Gln Gly Leu 
785                 790                 795                 800 


Phe Ile Phe Leu Phe His Cys Leu Leu Asn Ser Glu Val Arg Ala Ala 
                805                 810                 815     


Phe Lys His Lys Thr Lys Val Trp Ser Leu Thr Ser Ser Ser Ala Arg 
            820                 825                 830         


Thr Ser Asn Ala Lys Pro Phe His Ser Asp Leu Met Asn Gly Thr Arg 
        835                 840                 845             


Pro Gly Met Ala Ser Thr Lys Leu Ser Pro Trp Asp Lys Ser Ser His 
    850                 855                 860                 


Ser Ala His Arg Val Asp Leu Ser Ala Val 
865                 870                 


<210>  429
<211>  393
<212>  PRT
<213>  Homo Sapiens

<400>  429

Met His Arg Val Cys Phe Leu Ser Phe Gln Thr Arg Lys Gln His Ser 
1               5                   10                  15      


Glu Ala Thr Asn Ser Ser Asn Arg Val Phe Val Tyr Cys Ala Phe Leu 
            20                  25                  30          


Asp Phe Ser Ser Gly Glu Gly Val Trp Ser Asn His Gly Cys Ala Leu 
        35                  40                  45              


Thr Arg Gly Asn Leu Thr Tyr Ser Val Cys Arg Cys Thr His Leu Thr 
    50                  55                  60                  


Asn Phe Ala Ile Leu Met Gln Val Val Pro Leu Glu Leu Ala Arg Gly 
65                  70                  75                  80  


His Gln Val Ala Leu Ser Ser Ile Ser Tyr Val Gly Cys Ser Leu Ser 
                85                  90                  95      


Val Leu Cys Leu Val Ala Thr Leu Val Thr Phe Ala Val Leu Ser Ser 
            100                 105                 110         


Val Ser Thr Ile Arg Asn Gln Arg Tyr His Ile His Ala Asn Leu Ser 
        115                 120                 125             


Phe Ala Val Leu Val Ala Gln Val Leu Leu Leu Ile Ser Phe Arg Leu 
    130                 135                 140                 


Glu Pro Gly Thr Thr Pro Cys Gln Val Met Ala Val Leu Leu His Tyr 
145                 150                 155                 160 


Phe Phe Leu Ser Ala Phe Ala Trp Met Leu Val Glu Gly Leu His Leu 
                165                 170                 175     


Tyr Ser Met Val Ile Lys Val Phe Gly Ser Glu Asp Ser Lys His Arg 
            180                 185                 190         


Tyr Tyr Tyr Gly Met Gly Trp Gly Phe Pro Leu Leu Ile Cys Ile Ile 
        195                 200                 205             


Ser Leu Ser Phe Ala Met Asp Ser Tyr Gly Thr Ser Asn Asn Cys Trp 
    210                 215                 220                 


Leu Ser Leu Ala Ser Gly Ala Ile Trp Ala Phe Val Ala Pro Ala Leu 
225                 230                 235                 240 


Phe Val Ile Val Val Asn Ile Gly Ile Leu Ile Ala Val Thr Arg Val 
                245                 250                 255     


Ile Ser Gln Ile Ser Ala Asp Asn Tyr Lys Ile His Gly Asp Pro Ser 
            260                 265                 270         


Ala Phe Lys Leu Thr Ala Lys Ala Val Ala Val Leu Leu Pro Ile Leu 
        275                 280                 285             


Gly Thr Ser Trp Val Phe Gly Val Leu Ala Val Asn Gly Cys Ala Val 
    290                 295                 300                 


Val Phe Gln Tyr Met Phe Ala Thr Leu Asn Ser Leu Gln Gly Leu Phe 
305                 310                 315                 320 


Ile Phe Leu Phe His Cys Leu Leu Asn Ser Glu Val Arg Ala Ala Phe 
                325                 330                 335     


Lys His Lys Thr Lys Val Trp Ser Leu Thr Ser Ser Ser Ala Arg Thr 
            340                 345                 350         


Ser Asn Ala Lys Pro Phe His Ser Asp Leu Met Asn Gly Thr Arg Pro 
        355                 360                 365             


Gly Met Ala Ser Thr Lys Leu Ser Pro Trp Asp Lys Ser Ser His Ser 
    370                 375                 380                 


Ala His Arg Val Asp Leu Ser Ala Val 
385                 390             


<210>  430
<211>  345
<212>  PRT
<213>  Homo Sapiens

<400>  430

Met Gln Val Val Pro Leu Glu Leu Ala Arg Gly His Gln Val Ala Leu 
1               5                   10                  15      


Ser Ser Ile Ser Tyr Val Gly Cys Ser Leu Ser Val Leu Cys Leu Val 
            20                  25                  30          


Ala Thr Leu Val Thr Phe Ala Val Leu Ser Ser Val Ser Thr Ile Arg 
        35                  40                  45              


Asn Gln Arg Tyr His Ile His Ala Asn Leu Ser Phe Ala Val Leu Val 
    50                  55                  60                  


Ala Gln Val Leu Leu Leu Ile Ser Phe Arg Leu Glu Pro Gly Thr Thr 
65                  70                  75                  80  


Pro Cys Gln Val Met Ala Val Leu Leu His Tyr Phe Phe Leu Ser Ala 
                85                  90                  95      


Phe Ala Trp Met Leu Val Glu Gly Leu His Leu Tyr Ser Met Val Ile 
            100                 105                 110         


Lys Val Phe Gly Ser Glu Asp Ser Lys His Arg Tyr Tyr Tyr Gly Met 
        115                 120                 125             


Gly Trp Gly Phe Pro Leu Leu Ile Cys Ile Ile Ser Leu Ser Phe Ala 
    130                 135                 140                 


Met Asp Ser Tyr Gly Thr Ser Asn Asn Cys Trp Leu Ser Leu Ala Ser 
145                 150                 155                 160 


Gly Ala Ile Trp Ala Phe Val Ala Pro Ala Leu Phe Val Ile Val Val 
                165                 170                 175     


Asn Ile Gly Ile Leu Ile Ala Val Thr Arg Val Ile Ser Gln Ile Ser 
            180                 185                 190         


Ala Asp Asn Tyr Lys Ile His Gly Asp Pro Ser Ala Phe Lys Leu Thr 
        195                 200                 205             


Ala Lys Ala Val Ala Val Leu Leu Pro Ile Leu Gly Thr Ser Trp Val 
    210                 215                 220                 


Phe Gly Val Leu Ala Val Asn Gly Cys Ala Val Val Phe Gln Tyr Met 
225                 230                 235                 240 


Phe Ala Thr Leu Asn Ser Leu Gln Gly Leu Phe Ile Phe Leu Phe His 
                245                 250                 255     


Cys Leu Leu Asn Ser Glu Ala Arg Trp Ala Lys Glu Gly Arg Ala Glu 
            260                 265                 270         


Ser Leu Ser Arg Met Val Ala Gly Gln Lys Gly Cys Met Ile Thr Lys 
        275                 280                 285             


Pro Ser Asp Pro Leu Ile Ala Thr Pro Ser Asp Pro Leu Gln Gly Leu 
    290                 295                 300                 


Arg Trp Ile Pro Val Ala Gly Arg Gln Cys Ser His Gly Ser Pro Pro 
305                 310                 315                 320 


Ala His Pro Pro Ala Cys Pro Pro Arg Ile Cys Leu Phe Ala Ser Leu 
                325                 330                 335     


Ser His Ser Pro Arg Asp Ile His Cys 
            340                 345 


<210>  431
<211>  156
<212>  PRT
<213>  Homo Sapiens

<400>  431

Met Gln Val Val Pro Leu Glu Val Asn Ile Gly Ile Leu Ile Ala Val 
1               5                   10                  15      


Thr Arg Val Ile Ser Gln Ile Ser Ala Asp Asn Tyr Lys Ile His Gly 
            20                  25                  30          


Asp Pro Ser Ala Phe Lys Leu Thr Ala Lys Ala Val Ala Val Leu Leu 
        35                  40                  45              


Pro Ile Leu Gly Thr Ser Trp Val Phe Gly Val Leu Ala Val Asn Gly 
    50                  55                  60                  


Cys Ala Val Val Phe Gln Tyr Met Phe Ala Thr Leu Asn Ser Leu Gln 
65                  70                  75                  80  


Gly Leu Phe Ile Phe Leu Phe His Cys Leu Leu Asn Ser Glu Val Arg 
                85                  90                  95      


Ala Ala Phe Lys His Lys Thr Lys Val Trp Ser Leu Thr Ser Ser Ser 
            100                 105                 110         


Ala Arg Thr Ser Asn Ala Lys Pro Phe His Ser Asp Leu Met Asn Gly 
        115                 120                 125             


Thr Arg Pro Gly Met Ala Ser Thr Lys Leu Ser Pro Trp Asp Lys Ser 
    130                 135                 140                 


Ser His Ser Ala His Arg Val Asp Leu Ser Ala Val 
145                 150                 155     


<210>  432
<211>  437
<212>  PRT
<213>  Homo Sapiens

<400>  432

Met Asn Ser Met Asp Ile Arg Cys Ser Asp Ile Ile Gln Gly Asp Thr 
1               5                   10                  15      


Gln Gly Pro Ser Ala Ile Ala Phe Ile Ser Tyr Ser Ser Leu Gly Asn 
            20                  25                  30          


Ile Ile Asn Ala Thr Phe Phe Glu Glu Met Asp Lys Lys Asp Gln Val 
        35                  40                  45              


Tyr Leu Asn Ser Gln Val Val Ser Ala Ala Ile Gly Pro Lys Arg Asn 
    50                  55                  60                  


Val Ser Leu Ser Lys Ser Val Thr Leu Thr Phe Gln His Val Lys Met 
65                  70                  75                  80  


Thr Pro Ser Thr Lys Lys Val Phe Cys Val Tyr Trp Lys Ser Thr Gly 
                85                  90                  95      


Gln Gly Ser Gln Trp Ser Arg Asp Gly Cys Phe Leu Ile His Val Asn 
            100                 105                 110         


Lys Ser His Thr Met Cys Asn Cys Ser His Leu Ser Ser Phe Ala Val 
        115                 120                 125             


Leu Met Ala Leu Thr Ser Gln Glu Glu Asp Pro Val Leu Thr Val Ile 
    130                 135                 140                 


Thr Tyr Val Gly Leu Ser Val Ser Leu Leu Cys Leu Leu Leu Ala Ala 
145                 150                 155                 160 


Leu Thr Phe Leu Leu Cys Lys Ala Ile Arg Asn Thr Ser Thr Ser Leu 
                165                 170                 175     


His Leu Gln Leu Ser Leu Cys Leu Phe Leu Ala His Leu Leu Phe Leu 
            180                 185                 190         


Val Gly Ile Asp Arg Thr Glu Pro Lys Val Leu Cys Ser Ile Ile Ala 
        195                 200                 205             


Gly Ala Leu His Tyr Leu Tyr Leu Ala Ala Phe Thr Trp Met Leu Leu 
    210                 215                 220                 


Glu Gly Val His Leu Phe Leu Thr Ala Arg Asn Leu Thr Val Val Asn 
225                 230                 235                 240 


Tyr Ser Ser Ile Asn Arg Leu Met Lys Trp Ile Met Phe Pro Val Gly 
                245                 250                 255     


Tyr Gly Val Pro Ala Val Thr Val Ala Ile Ser Ala Ala Ser Trp Pro 
            260                 265                 270         


His Leu Tyr Gly Thr Ala Asp Arg Cys Trp Leu His Leu Asp Gln Gly 
        275                 280                 285             


Phe Met Trp Ser Phe Leu Gly Pro Val Cys Ala Ile Phe Ser Ala Asn 
    290                 295                 300                 


Leu Val Leu Phe Ile Leu Val Phe Trp Ile Leu Lys Arg Lys Leu Ser 
305                 310                 315                 320 


Ser Leu Asn Ser Glu Val Ser Thr Ile Gln Asn Thr Arg Met Leu Ala 
                325                 330                 335     


Phe Lys Ala Thr Ala Gln Leu Phe Ile Leu Gly Cys Thr Trp Cys Leu 
            340                 345                 350         


Gly Leu Leu Gln Val Gly Pro Ala Ala Gln Val Met Ala Tyr Leu Phe 
        355                 360                 365             


Thr Ile Ile Asn Ser Leu Gln Gly Phe Phe Ile Phe Leu Val Tyr Cys 
    370                 375                 380                 


Leu Leu Ser Gln Gln Val Gln Lys Gln Tyr Gln Lys Trp Phe Arg Glu 
385                 390                 395                 400 


Ile Val Lys Ser Lys Ser Glu Ser Glu Thr Tyr Thr Leu Ser Ser Lys 
                405                 410                 415     


Met Gly Pro Asp Ser Lys Pro Ser Glu Gly Asp Val Phe Pro Gly Gln 
            420                 425                 430         


Val Lys Arg Lys Tyr 
        435         


<210>  433
<211>  57
<212>  PRT
<213>  Homo Sapiens

<400>  433

Met Gln Gly Pro Leu Leu Leu Pro Gly Leu Cys Phe Leu Leu Ser Leu 
1               5                   10                  15      


Phe Gly Ala Val Thr Gln Lys Thr Lys Ser Glu Cys Ser Glu Pro Glu 
            20                  25                  30          


Gln Arg Thr Cys Gly Pro Arg Ala Gly Pro Gly Ala Thr His Gly Leu 
        35                  40                  45              


Gln Trp Ala Gly Glu Lys Cys Leu Phe 
    50                  55          


<210>  434
<211>  526
<212>  PRT
<213>  Homo Sapiens

<400>  434

Met Gln Gly Pro Leu Leu Leu Pro Gly Leu Cys Phe Leu Leu Ser Leu 
1               5                   10                  15      


Phe Gly Ala Val Thr Gln Lys Thr Lys Thr Ser Cys Ala Lys Cys Pro 
            20                  25                  30          


Pro Asn Ala Ser Cys Val Asn Asn Thr His Cys Thr Cys Asn His Gly 
        35                  40                  45              


Tyr Thr Ser Gly Ser Gly Gln Lys Leu Phe Thr Phe Pro Leu Glu Thr 
    50                  55                  60                  


Cys Asn Ala Ile Glu Thr Gln Ala Ile Thr Asp Asn Cys Ser Glu Glu 
65                  70                  75                  80  


Arg Lys Thr Phe Asn Leu Asn Val Gln Met Asn Ser Met Asp Ile Arg 
                85                  90                  95      


Cys Ser Asp Ile Ile Gln Gly Asp Thr Gln Gly Pro Ser Ala Ile Ala 
            100                 105                 110         


Phe Ile Ser Tyr Ser Ser Leu Gly Asn Ile Ile Asn Ala Thr Phe Phe 
        115                 120                 125             


Glu Glu Met Asp Lys Lys Asp Gln Val Tyr Leu Asn Ser Gln Val Val 
    130                 135                 140                 


Ser Ala Ala Ile Gly Pro Lys Arg Asn Val Ser Leu Ser Lys Ser Val 
145                 150                 155                 160 


Thr Leu Thr Phe Gln His Val Lys Met Thr Pro Ser Thr Lys Lys Val 
                165                 170                 175     


Phe Cys Val Tyr Trp Lys Ser Thr Gly Gln Gly Ser Gln Trp Ser Arg 
            180                 185                 190         


Asp Gly Cys Phe Leu Ile His Val Asn Lys Ser His Thr Met Cys Asn 
        195                 200                 205             


Cys Ser His Leu Ser Ser Phe Ala Val Leu Met Ala Leu Thr Ser Gln 
    210                 215                 220                 


Glu Glu Asp Pro Val Leu Thr Val Ile Thr Tyr Val Gly Leu Ser Val 
225                 230                 235                 240 


Ser Leu Leu Cys Leu Leu Leu Ala Ala Leu Thr Phe Leu Leu Cys Lys 
                245                 250                 255     


Ala Ile Arg Asn Thr Ser Thr Ser Leu His Leu Gln Leu Ser Leu Cys 
            260                 265                 270         


Leu Phe Leu Ala His Leu Leu Phe Leu Val Gly Ile Asp Arg Thr Glu 
        275                 280                 285             


Pro Lys Val Leu Cys Ser Ile Ile Ala Gly Ala Leu His Tyr Leu Tyr 
    290                 295                 300                 


Leu Ala Ala Phe Thr Trp Met Leu Leu Glu Gly Val His Leu Phe Leu 
305                 310                 315                 320 


Thr Ala Arg Asn Leu Thr Val Val Asn Tyr Ser Ser Ile Asn Arg Leu 
                325                 330                 335     


Met Lys Trp Ile Met Phe Pro Val Gly Tyr Gly Val Pro Ala Val Thr 
            340                 345                 350         


Val Ala Ile Ser Ala Ala Ser Trp Pro His Leu Tyr Gly Thr Ala Asp 
        355                 360                 365             


Arg Cys Trp Leu His Leu Asp Gln Gly Phe Met Trp Ser Phe Leu Gly 
    370                 375                 380                 


Pro Val Cys Ala Ile Phe Ser Ala Asn Leu Val Leu Phe Ile Leu Val 
385                 390                 395                 400 


Phe Trp Ile Leu Lys Arg Lys Leu Ser Ser Leu Asn Ser Glu Val Ser 
                405                 410                 415     


Thr Ile Gln Asn Thr Arg Met Leu Ala Phe Lys Ala Thr Ala Gln Leu 
            420                 425                 430         


Phe Ile Leu Gly Cys Thr Trp Cys Leu Gly Leu Leu Gln Val Gly Pro 
        435                 440                 445             


Ala Ala Gln Val Met Ala Tyr Leu Phe Thr Ile Ile Asn Ser Leu Gln 
    450                 455                 460                 


Gly Phe Phe Ile Phe Leu Val Tyr Cys Leu Leu Ser Gln Gln Val Gln 
465                 470                 475                 480 


Lys Gln Tyr Gln Lys Trp Phe Arg Glu Ile Val Lys Ser Lys Ser Glu 
                485                 490                 495     


Ser Glu Thr Tyr Thr Leu Ser Ser Lys Met Gly Pro Asp Ser Lys Pro 
            500                 505                 510         


Ser Glu Gly Asp Val Phe Pro Gly Gln Val Lys Arg Lys Tyr 
        515                 520                 525     


<210>  435
<211>  652
<212>  PRT
<213>  Homo Sapiens

<400>  435

Met Gln Gly Pro Leu Leu Leu Pro Gly Leu Cys Phe Leu Leu Ser Leu 
1               5                   10                  15      


Phe Gly Ala Val Thr Gln Lys Thr Lys Thr Ser Cys Ala Lys Cys Pro 
            20                  25                  30          


Pro Asn Ala Ser Cys Val Asn Asn Thr His Cys Thr Cys Asn His Gly 
        35                  40                  45              


Tyr Thr Ser Gly Ser Gly Gln Lys Leu Phe Thr Phe Pro Leu Glu Thr 
    50                  55                  60                  


Cys Asn Asp Ile Asn Glu Cys Thr Pro Pro Tyr Ser Val Tyr Cys Gly 
65                  70                  75                  80  


Phe Asn Ala Val Cys Tyr Asn Val Glu Gly Ser Phe Tyr Cys Gln Cys 
                85                  90                  95      


Val Pro Gly Tyr Arg Leu His Ser Gly Asn Glu Gln Phe Ser Asn Ser 
            100                 105                 110         


Asn Glu Asn Thr Cys Gln Asp Thr Thr Ser Ser Lys Thr Thr Glu Gly 
        115                 120                 125             


Arg Lys Glu Leu Gln Lys Ile Val Asp Lys Phe Glu Ser Leu Leu Thr 
    130                 135                 140                 


Asn Gln Thr Leu Trp Arg Thr Glu Gly Arg Gln Glu Ile Ser Ser Thr 
145                 150                 155                 160 


Ala Thr Thr Ile Leu Arg Asp Val Glu Ser Lys Val Leu Glu Thr Ala 
                165                 170                 175     


Leu Lys Asp Pro Glu Gln Lys Val Leu Lys Ile Gln Asn Asp Ser Val 
            180                 185                 190         


Ala Ile Glu Thr Gln Ala Ile Thr Asp Asn Cys Ser Glu Glu Arg Lys 
        195                 200                 205             


Thr Phe Asn Leu Asn Val Gln Met Asn Ser Met Asp Ile Arg Cys Ser 
    210                 215                 220                 


Asp Ile Ile Gln Gly Asp Thr Gln Gly Pro Ser Ala Ile Ala Phe Ile 
225                 230                 235                 240 


Ser Tyr Ser Ser Leu Gly Asn Ile Ile Asn Ala Thr Phe Phe Glu Glu 
                245                 250                 255     


Met Asp Lys Lys Asp Gln Val Tyr Leu Asn Ser Gln Val Val Ser Ala 
            260                 265                 270         


Ala Ile Gly Pro Lys Arg Asn Val Ser Leu Ser Lys Ser Val Thr Leu 
        275                 280                 285             


Thr Phe Gln His Val Lys Met Thr Pro Ser Thr Lys Lys Val Phe Cys 
    290                 295                 300                 


Val Tyr Trp Lys Ser Thr Gly Gln Gly Ser Gln Trp Ser Arg Asp Gly 
305                 310                 315                 320 


Cys Phe Leu Ile His Val Asn Lys Ser His Thr Met Cys Asn Cys Ser 
                325                 330                 335     


His Leu Ser Ser Phe Ala Val Leu Met Ala Leu Thr Ser Gln Glu Glu 
            340                 345                 350         


Asp Pro Val Leu Thr Val Ile Thr Tyr Val Gly Leu Ser Val Ser Leu 
        355                 360                 365             


Leu Cys Leu Leu Leu Ala Ala Leu Thr Phe Leu Leu Cys Lys Ala Ile 
    370                 375                 380                 


Arg Asn Thr Ser Thr Ser Leu His Leu Gln Leu Ser Leu Cys Leu Phe 
385                 390                 395                 400 


Leu Ala His Leu Leu Phe Leu Val Gly Ile Asp Arg Thr Glu Pro Lys 
                405                 410                 415     


Val Leu Cys Ser Ile Ile Ala Gly Ala Leu His Tyr Leu Tyr Leu Ala 
            420                 425                 430         


Ala Phe Thr Trp Met Leu Leu Glu Gly Val His Leu Phe Leu Thr Ala 
        435                 440                 445             


Arg Asn Leu Thr Val Val Asn Tyr Ser Ser Ile Asn Arg Leu Met Lys 
    450                 455                 460                 


Trp Ile Met Phe Pro Val Gly Tyr Gly Val Pro Ala Val Thr Val Ala 
465                 470                 475                 480 


Ile Ser Ala Ala Ser Trp Pro His Leu Tyr Gly Thr Ala Asp Arg Cys 
                485                 490                 495     


Trp Leu His Leu Asp Gln Gly Phe Met Trp Ser Phe Leu Gly Pro Val 
            500                 505                 510         


Cys Ala Ile Phe Ser Ala Asn Leu Val Leu Phe Ile Leu Val Phe Trp 
        515                 520                 525             


Ile Leu Lys Arg Lys Leu Ser Ser Leu Asn Ser Glu Val Ser Thr Ile 
    530                 535                 540                 


Gln Asn Thr Arg Met Leu Ala Phe Lys Ala Thr Ala Gln Leu Phe Ile 
545                 550                 555                 560 


Leu Gly Cys Thr Trp Cys Leu Gly Leu Leu Gln Val Gly Pro Ala Ala 
                565                 570                 575     


Gln Val Met Ala Tyr Leu Phe Thr Ile Ile Asn Ser Leu Gln Gly Phe 
            580                 585                 590         


Phe Ile Phe Leu Val Tyr Cys Leu Leu Ser Gln Gln Val Gln Lys Gln 
        595                 600                 605             


Tyr Gln Lys Trp Phe Arg Glu Ile Val Lys Ser Lys Ser Glu Ser Glu 
    610                 615                 620                 


Thr Tyr Thr Leu Ser Ser Lys Met Gly Pro Asp Ser Lys Pro Ser Glu 
625                 630                 635                 640 


Gly Asp Val Phe Pro Gly Gln Val Lys Arg Lys Tyr 
                645                 650         


<210>  436
<211>  600
<212>  PRT
<213>  Homo Sapiens

<400>  436

Met Gln Gly Pro Leu Leu Leu Pro Gly Leu Cys Phe Leu Leu Ser Leu 
1               5                   10                  15      


Phe Gly Ala Val Thr Gln Lys Thr Lys Thr Ser Cys Ala Lys Cys Pro 
            20                  25                  30          


Pro Asn Ala Ser Cys Val Asn Asn Thr His Cys Thr Cys Asn His Gly 
        35                  40                  45              


Tyr Thr Ser Gly Ser Gly Gln Lys Leu Phe Thr Phe Pro Leu Glu Thr 
    50                  55                  60                  


Cys Asn Asp Thr Thr Ser Ser Lys Thr Thr Glu Gly Arg Lys Glu Leu 
65                  70                  75                  80  


Gln Lys Ile Val Asp Lys Phe Glu Ser Leu Leu Thr Asn Gln Thr Leu 
                85                  90                  95      


Trp Arg Thr Glu Gly Arg Gln Glu Ile Ser Ser Thr Ala Thr Thr Ile 
            100                 105                 110         


Leu Arg Asp Val Glu Ser Lys Val Leu Glu Thr Ala Leu Lys Asp Pro 
        115                 120                 125             


Glu Gln Lys Val Leu Lys Ile Gln Asn Asp Ser Val Ala Ile Glu Thr 
    130                 135                 140                 


Gln Ala Ile Thr Asp Asn Cys Ser Glu Glu Arg Lys Thr Phe Asn Leu 
145                 150                 155                 160 


Asn Val Gln Met Asn Ser Met Asp Ile Arg Cys Ser Asp Ile Ile Gln 
                165                 170                 175     


Gly Asp Thr Gln Gly Pro Ser Ala Ile Ala Phe Ile Ser Tyr Ser Ser 
            180                 185                 190         


Leu Gly Asn Ile Ile Asn Ala Thr Phe Phe Glu Glu Met Asp Lys Lys 
        195                 200                 205             


Asp Gln Val Tyr Leu Asn Ser Gln Val Val Ser Ala Ala Ile Gly Pro 
    210                 215                 220                 


Lys Arg Asn Val Ser Leu Ser Lys Ser Val Thr Leu Thr Phe Gln His 
225                 230                 235                 240 


Val Lys Met Thr Pro Ser Thr Lys Lys Val Phe Cys Val Tyr Trp Lys 
                245                 250                 255     


Ser Thr Gly Gln Gly Ser Gln Trp Ser Arg Asp Gly Cys Phe Leu Ile 
            260                 265                 270         


His Val Asn Lys Ser His Thr Met Cys Asn Cys Ser His Leu Ser Ser 
        275                 280                 285             


Phe Ala Val Leu Met Ala Leu Thr Ser Gln Glu Glu Asp Pro Val Leu 
    290                 295                 300                 


Thr Val Ile Thr Tyr Val Gly Leu Ser Val Ser Leu Leu Cys Leu Leu 
305                 310                 315                 320 


Leu Ala Ala Leu Thr Phe Leu Leu Cys Lys Ala Ile Arg Asn Thr Ser 
                325                 330                 335     


Thr Ser Leu His Leu Gln Leu Ser Leu Cys Leu Phe Leu Ala His Leu 
            340                 345                 350         


Leu Phe Leu Val Gly Ile Asp Arg Thr Glu Pro Lys Val Leu Cys Ser 
        355                 360                 365             


Ile Ile Ala Gly Ala Leu His Tyr Leu Tyr Leu Ala Ala Phe Thr Trp 
    370                 375                 380                 


Met Leu Leu Glu Gly Val His Leu Phe Leu Thr Ala Arg Asn Leu Thr 
385                 390                 395                 400 


Val Val Asn Tyr Ser Ser Ile Asn Arg Leu Met Lys Trp Ile Met Phe 
                405                 410                 415     


Pro Val Gly Tyr Gly Val Pro Ala Val Thr Val Ala Ile Ser Ala Ala 
            420                 425                 430         


Ser Trp Pro His Leu Tyr Gly Thr Ala Asp Arg Cys Trp Leu His Leu 
        435                 440                 445             


Asp Gln Gly Phe Met Trp Ser Phe Leu Gly Pro Val Cys Ala Ile Phe 
    450                 455                 460                 


Ser Ala Asn Leu Val Leu Phe Ile Leu Val Phe Trp Ile Leu Lys Arg 
465                 470                 475                 480 


Lys Leu Ser Ser Leu Asn Ser Glu Val Ser Thr Ile Gln Asn Thr Arg 
                485                 490                 495     


Met Leu Ala Phe Lys Ala Thr Ala Gln Leu Phe Ile Leu Gly Cys Thr 
            500                 505                 510         


Trp Cys Leu Gly Leu Leu Gln Val Gly Pro Ala Ala Gln Val Met Ala 
        515                 520                 525             


Tyr Leu Phe Thr Ile Ile Asn Ser Leu Gln Gly Phe Phe Ile Phe Leu 
    530                 535                 540                 


Val Tyr Cys Leu Leu Ser Gln Gln Val Gln Lys Gln Tyr Gln Lys Trp 
545                 550                 555                 560 


Phe Arg Glu Ile Val Lys Ser Lys Ser Glu Ser Glu Thr Tyr Thr Leu 
                565                 570                 575     


Ser Ser Lys Met Gly Pro Asp Ser Lys Pro Ser Glu Gly Asp Val Phe 
            580                 585                 590         


Pro Gly Gln Val Lys Arg Lys Tyr 
        595                 600 


<210>  437
<211>  786
<212>  PRT
<213>  Homo Sapiens

<400>  437

Met Gly Gly Arg Val Phe Leu Ala Phe Cys Val Trp Leu Thr Leu Pro 
1               5                   10                  15      


Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp Cys Pro Gln 
            20                  25                  30          


Asn Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn Pro Gly Phe 
        35                  40                  45              


Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Thr Glu Thr Cys Asp Asp 
    50                  55                  60                  


Ile Asn Glu Cys Ala Thr Pro Ser Lys Val Ser Cys Gly Lys Phe Ser 
65                  70                  75                  80  


Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys Ser Pro Gly 
                85                  90                  95      


Tyr Glu Pro Val Ser Gly Ala Lys Thr Phe Lys Asn Glu Ser Glu Asn 
            100                 105                 110         


Thr Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg Leu Cys Lys 
        115                 120                 125             


Ser Tyr Gly Thr Cys Val Asn Thr Leu Gly Ser Tyr Thr Cys Gln Cys 
    130                 135                 140                 


Leu Pro Gly Phe Lys Phe Ile Pro Glu Asp Pro Lys Val Cys Thr Asp 
145                 150                 155                 160 


Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp Ser Ser Thr Val 
                165                 170                 175     


Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys Arg Pro Gly Trp 
            180                 185                 190         


Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp Thr Val Cys Glu 
        195                 200                 205             


Asp Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly Val His Ser Gln 
    210                 215                 220                 


Thr Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu Gly Arg Asp Ser 
225                 230                 235                 240 


Lys Thr Ser Ser Ala Glu Val Thr Ile Gln Asn Val Ile Lys Leu Val 
                245                 250                 255     


Asp Glu Leu Met Glu Ala Pro Gly Asp Val Glu Ala Leu Ala Pro Pro 
            260                 265                 270         


Val Arg His Leu Ile Ala Thr Gln Leu Leu Ser Asn Leu Glu Asp Ile 
        275                 280                 285             


Met Arg Ile Leu Ala Lys Ser Leu Pro Lys Gly Pro Phe Thr Tyr Ile 
    290                 295                 300                 


Ser Pro Ser Asn Thr Glu Leu Thr Leu Met Ile Gln Glu Arg Gly Asp 
305                 310                 315                 320 


Lys Asn Val Thr Met Gly Gln Ser Ser Ala Arg Met Lys Leu Asn Trp 
                325                 330                 335     


Ala Val Ala Ala Gly Ala Glu Asp Pro Gly Pro Ala Val Ala Gly Ile 
            340                 345                 350         


Leu Ser Ile Gln Asn Met Thr Thr Leu Leu Ala Asn Ala Ser Leu Asn 
        355                 360                 365             


Leu His Ser Lys Lys Gln Ala Glu Leu Glu Glu Ile Tyr Glu Ser Ser 
    370                 375                 380                 


Ile Arg Gly Val Gln Leu Arg Arg Leu Ser Ala Val Asn Ser Ile Phe 
385                 390                 395                 400 


Leu Ser His Asn Asn Thr Lys Glu Leu Asn Ser Pro Ile Leu Phe Ala 
                405                 410                 415     


Phe Ser His Leu Glu Ser Ser Asp Gly Glu Ala Gly Arg Asp Pro Pro 
            420                 425                 430         


Ala Lys Asp Val Met Pro Gly Pro Arg Gln Glu Leu Leu Cys Ala Phe 
        435                 440                 445             


Trp Lys Ser Asp Ser Asp Arg Gly Gly His Trp Ala Thr Glu Gly Cys 
    450                 455                 460                 


Gln Val Leu Gly Ser Lys Asn Gly Ser Thr Thr Cys Gln Cys Ser His 
465                 470                 475                 480 


Leu Ser Ser Phe Ala Ile Leu Met Ala His Tyr Asp Val Glu Asp Trp 
                485                 490                 495     


Lys Leu Thr Leu Ile Thr Arg Val Gly Leu Ala Leu Ser Leu Phe Cys 
            500                 505                 510         


Leu Leu Leu Cys Ile Leu Thr Phe Leu Leu Val Arg Pro Ile Gln Gly 
        515                 520                 525             


Ser Arg Thr Thr Ile His Leu His Leu Cys Ile Cys Leu Phe Val Gly 
    530                 535                 540                 


Ser Thr Ile Phe Leu Ala Gly Ile Glu Asn Glu Gly Gly Gln Val Gly 
545                 550                 555                 560 


Leu Arg Cys Arg Leu Val Ala Gly Leu Leu His Tyr Cys Phe Leu Ala 
                565                 570                 575     


Ala Phe Cys Trp Met Ser Leu Glu Gly Leu Glu Leu Tyr Phe Leu Val 
            580                 585                 590         


Val Arg Val Phe Gln Gly Gln Gly Leu Ser Thr Arg Trp Leu Cys Leu 
        595                 600                 605             


Ile Gly Tyr Gly Val Pro Leu Leu Ile Val Gly Val Ser Ala Ala Ile 
    610                 615                 620                 


Tyr Ser Lys Gly Tyr Gly Arg Pro Arg Tyr Cys Trp Leu Asp Phe Glu 
625                 630                 635                 640 


Gln Gly Phe Leu Trp Ser Phe Leu Gly Pro Val Thr Phe Ile Ile Leu 
                645                 650                 655     


Cys Asn Ala Val Ile Phe Val Thr Thr Val Trp Lys Leu Thr Gln Lys 
            660                 665                 670         


Phe Ser Glu Ile Asn Pro Asp Met Lys Lys Leu Lys Lys Ala Arg Ala 
        675                 680                 685             


Leu Thr Ile Thr Ala Ile Ala Gln Leu Phe Leu Leu Gly Cys Thr Trp 
    690                 695                 700                 


Val Phe Gly Leu Phe Ile Phe Asp Asp Arg Ser Leu Val Leu Thr Tyr 
705                 710                 715                 720 


Val Phe Thr Ile Leu Asn Cys Leu Gln Gly Ala Phe Leu Tyr Leu Leu 
                725                 730                 735     


His Cys Leu Leu Asn Lys Lys Val Arg Glu Glu Tyr Arg Lys Trp Ala 
            740                 745                 750         


Cys Leu Val Ala Gly Gly Ser Lys Tyr Ser Glu Phe Thr Ser Thr Thr 
        755                 760                 765             


Ser Gly Thr Gly His Asn Gln Thr Arg Ala Leu Arg Ala Ser Glu Ser 
    770                 775                 780                 


Gly Ile 
785     


<210>  438
<211>  835
<212>  PRT
<213>  Homo Sapiens

<400>  438

Met Gly Gly Arg Val Phe Leu Ala Phe Cys Val Trp Leu Thr Leu Pro 
1               5                   10                  15      


Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp Cys Pro Gln 
            20                  25                  30          


Asn Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn Pro Gly Phe 
        35                  40                  45              


Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Thr Glu Thr Cys Asp Asp 
    50                  55                  60                  


Ile Asn Glu Cys Ala Thr Pro Ser Lys Val Ser Cys Gly Lys Phe Ser 
65                  70                  75                  80  


Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys Ser Pro Gly 
                85                  90                  95      


Tyr Glu Pro Val Ser Gly Ala Lys Thr Phe Lys Asn Glu Ser Glu Asn 
            100                 105                 110         


Thr Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg Leu Cys Lys 
        115                 120                 125             


Ser Tyr Gly Thr Cys Val Asn Thr Leu Gly Ser Tyr Thr Cys Gln Cys 
    130                 135                 140                 


Leu Pro Gly Phe Lys Phe Ile Pro Glu Asp Pro Lys Val Cys Thr Asp 
145                 150                 155                 160 


Val Asn Glu Cys Thr Ser Gly Gln Asn Pro Cys His Ser Ser Thr His 
                165                 170                 175     


Cys Leu Asn Asn Val Gly Ser Tyr Gln Cys Arg Cys Arg Pro Gly Trp 
            180                 185                 190         


Gln Pro Ile Pro Gly Ser Pro Asn Gly Pro Asn Asn Thr Val Cys Glu 
        195                 200                 205             


Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp Ser Ser Thr 
    210                 215                 220                 


Val Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys Arg Pro Gly 
225                 230                 235                 240 


Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp Thr Val Cys 
                245                 250                 255     


Glu Asp Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly Val His Ser 
            260                 265                 270         


Gln Thr Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu Gly Arg Asp 
        275                 280                 285             


Ser Lys Thr Ser Ser Ala Glu Val Thr Ile Gln Asn Val Ile Lys Leu 
    290                 295                 300                 


Val Asp Glu Leu Met Glu Ala Pro Gly Asp Val Glu Ala Leu Ala Pro 
305                 310                 315                 320 


Pro Val Arg His Leu Ile Ala Thr Gln Leu Leu Ser Asn Leu Glu Asp 
                325                 330                 335     


Ile Met Arg Ile Leu Ala Lys Ser Leu Pro Lys Gly Pro Phe Thr Tyr 
            340                 345                 350         


Ile Ser Pro Ser Asn Thr Glu Leu Thr Leu Met Ile Gln Glu Arg Gly 
        355                 360                 365             


Asp Lys Asn Val Thr Met Gly Gln Ser Ser Ala Arg Met Lys Leu Asn 
    370                 375                 380                 


Trp Ala Val Ala Ala Gly Ala Glu Asp Pro Gly Pro Ala Val Ala Gly 
385                 390                 395                 400 


Ile Leu Ser Ile Gln Asn Met Thr Thr Leu Leu Ala Asn Ala Ser Leu 
                405                 410                 415     


Asn Leu His Ser Lys Lys Gln Ala Glu Leu Glu Glu Ile Tyr Glu Ser 
            420                 425                 430         


Ser Ile Arg Gly Val Gln Leu Arg Arg Leu Ser Ala Val Asn Ser Ile 
        435                 440                 445             


Phe Leu Ser His Asn Asn Thr Lys Glu Leu Asn Ser Pro Ile Leu Phe 
    450                 455                 460                 


Ala Phe Ser His Leu Glu Ser Ser Asp Gly Glu Ala Gly Arg Asp Pro 
465                 470                 475                 480 


Pro Ala Lys Asp Val Met Pro Gly Pro Arg Gln Glu Leu Leu Cys Ala 
                485                 490                 495     


Phe Trp Lys Ser Asp Ser Asp Arg Gly Gly His Trp Ala Thr Glu Gly 
            500                 505                 510         


Cys Gln Val Leu Gly Ser Lys Asn Gly Ser Thr Thr Cys Gln Cys Ser 
        515                 520                 525             


His Leu Ser Ser Phe Ala Ile Leu Met Ala His Tyr Asp Val Glu Asp 
    530                 535                 540                 


Trp Lys Leu Thr Leu Ile Thr Arg Val Gly Leu Ala Leu Ser Leu Phe 
545                 550                 555                 560 


Cys Leu Leu Leu Cys Ile Leu Thr Phe Leu Leu Val Arg Pro Ile Gln 
                565                 570                 575     


Gly Ser Arg Thr Thr Ile His Leu His Leu Cys Ile Cys Leu Phe Val 
            580                 585                 590         


Gly Ser Thr Ile Phe Leu Ala Gly Ile Glu Asn Glu Gly Gly Gln Val 
        595                 600                 605             


Gly Leu Arg Cys Arg Leu Val Ala Gly Leu Leu His Tyr Cys Phe Leu 
    610                 615                 620                 


Ala Ala Phe Cys Trp Met Ser Leu Glu Gly Leu Glu Leu Tyr Phe Leu 
625                 630                 635                 640 


Val Val Arg Val Phe Gln Gly Gln Gly Leu Ser Thr Arg Trp Leu Cys 
                645                 650                 655     


Leu Ile Gly Tyr Gly Val Pro Leu Leu Ile Val Gly Val Ser Ala Ala 
            660                 665                 670         


Ile Tyr Ser Lys Gly Tyr Gly Arg Pro Arg Tyr Cys Trp Leu Asp Phe 
        675                 680                 685             


Glu Gln Gly Phe Leu Trp Ser Phe Leu Gly Pro Val Thr Phe Ile Ile 
    690                 695                 700                 


Leu Cys Asn Ala Val Ile Phe Val Thr Thr Val Trp Lys Leu Thr Gln 
705                 710                 715                 720 


Lys Phe Ser Glu Ile Asn Pro Asp Met Lys Lys Leu Lys Lys Ala Arg 
                725                 730                 735     


Ala Leu Thr Ile Thr Ala Ile Ala Gln Leu Phe Leu Leu Gly Cys Thr 
            740                 745                 750         


Trp Val Phe Gly Leu Phe Ile Phe Asp Asp Arg Ser Leu Val Leu Thr 
        755                 760                 765             


Tyr Val Phe Thr Ile Leu Asn Cys Leu Gln Gly Ala Phe Leu Tyr Leu 
    770                 775                 780                 


Leu His Cys Leu Leu Asn Lys Lys Val Arg Glu Glu Tyr Arg Lys Trp 
785                 790                 795                 800 


Ala Cys Leu Val Ala Gly Gly Ser Lys Tyr Ser Glu Phe Thr Ser Thr 
                805                 810                 815     


Thr Ser Gly Thr Gly His Asn Gln Thr Arg Ala Leu Arg Ala Ser Glu 
            820                 825                 830         


Ser Gly Ile 
        835 


<210>  439
<211>  742
<212>  PRT
<213>  Homo Sapiens

<400>  439

Met Gly Gly Arg Val Phe Leu Ala Phe Cys Val Trp Leu Thr Leu Pro 
1               5                   10                  15      


Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp Cys Pro Gln 
            20                  25                  30          


Asn Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn Pro Gly Phe 
        35                  40                  45              


Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Thr Glu Thr Cys Asp Asp 
    50                  55                  60                  


Ile Asn Glu Cys Ala Thr Pro Ser Lys Val Ser Cys Gly Lys Phe Ser 
65                  70                  75                  80  


Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys Ser Pro Gly 
                85                  90                  95      


Tyr Glu Pro Val Ser Gly Ala Lys Thr Phe Lys Asn Glu Ser Glu Asn 
            100                 105                 110         


Thr Cys Gln Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp 
        115                 120                 125             


Ser Ser Thr Val Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys 
    130                 135                 140                 


Arg Pro Gly Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp 
145                 150                 155                 160 


Thr Val Cys Glu Asp Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly 
                165                 170                 175     


Val His Ser Gln Thr Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu 
            180                 185                 190         


Gly Arg Asp Ser Lys Thr Ser Ser Ala Glu Val Thr Ile Gln Asn Val 
        195                 200                 205             


Ile Lys Leu Val Asp Glu Leu Met Glu Ala Pro Gly Asp Val Glu Ala 
    210                 215                 220                 


Leu Ala Pro Pro Val Arg His Leu Ile Ala Thr Gln Leu Leu Ser Asn 
225                 230                 235                 240 


Leu Glu Asp Ile Met Arg Ile Leu Ala Lys Ser Leu Pro Lys Gly Pro 
                245                 250                 255     


Phe Thr Tyr Ile Ser Pro Ser Asn Thr Glu Leu Thr Leu Met Ile Gln 
            260                 265                 270         


Glu Arg Gly Asp Lys Asn Val Thr Met Gly Gln Ser Ser Ala Arg Met 
        275                 280                 285             


Lys Leu Asn Trp Ala Val Ala Ala Gly Ala Glu Asp Pro Gly Pro Ala 
    290                 295                 300                 


Val Ala Gly Ile Leu Ser Ile Gln Asn Met Thr Thr Leu Leu Ala Asn 
305                 310                 315                 320 


Ala Ser Leu Asn Leu His Ser Lys Lys Gln Ala Glu Leu Glu Glu Ile 
                325                 330                 335     


Tyr Glu Ser Ser Ile Arg Gly Val Gln Leu Arg Arg Leu Ser Ala Val 
            340                 345                 350         


Asn Ser Ile Phe Leu Ser His Asn Asn Thr Lys Glu Leu Asn Ser Pro 
        355                 360                 365             


Ile Leu Phe Ala Phe Ser His Leu Glu Ser Ser Asp Gly Glu Ala Gly 
    370                 375                 380                 


Arg Asp Pro Pro Ala Lys Asp Val Met Pro Gly Pro Arg Gln Glu Leu 
385                 390                 395                 400 


Leu Cys Ala Phe Trp Lys Ser Asp Ser Asp Arg Gly Gly His Trp Ala 
                405                 410                 415     


Thr Glu Gly Cys Gln Val Leu Gly Ser Lys Asn Gly Ser Thr Thr Cys 
            420                 425                 430         


Gln Cys Ser His Leu Ser Ser Phe Ala Ile Leu Met Ala His Tyr Asp 
        435                 440                 445             


Val Glu Asp Trp Lys Leu Thr Leu Ile Thr Arg Val Gly Leu Ala Leu 
    450                 455                 460                 


Ser Leu Phe Cys Leu Leu Leu Cys Ile Leu Thr Phe Leu Leu Val Arg 
465                 470                 475                 480 


Pro Ile Gln Gly Ser Arg Thr Thr Ile His Leu His Leu Cys Ile Cys 
                485                 490                 495     


Leu Phe Val Gly Ser Thr Ile Phe Leu Ala Gly Ile Glu Asn Glu Gly 
            500                 505                 510         


Gly Gln Val Gly Leu Arg Cys Arg Leu Val Ala Gly Leu Leu His Tyr 
        515                 520                 525             


Cys Phe Leu Ala Ala Phe Cys Trp Met Ser Leu Glu Gly Leu Glu Leu 
    530                 535                 540                 


Tyr Phe Leu Val Val Arg Val Phe Gln Gly Gln Gly Leu Ser Thr Arg 
545                 550                 555                 560 


Trp Leu Cys Leu Ile Gly Tyr Gly Val Pro Leu Leu Ile Val Gly Val 
                565                 570                 575     


Ser Ala Ala Ile Tyr Ser Lys Gly Tyr Gly Arg Pro Arg Tyr Cys Trp 
            580                 585                 590         


Leu Asp Phe Glu Gln Gly Phe Leu Trp Ser Phe Leu Gly Pro Val Thr 
        595                 600                 605             


Phe Ile Ile Leu Cys Asn Ala Val Ile Phe Val Thr Thr Val Trp Lys 
    610                 615                 620                 


Leu Thr Gln Lys Phe Ser Glu Ile Asn Pro Asp Met Lys Lys Leu Lys 
625                 630                 635                 640 


Lys Ala Arg Ala Leu Thr Ile Thr Ala Ile Ala Gln Leu Phe Leu Leu 
                645                 650                 655     


Gly Cys Thr Trp Val Phe Gly Leu Phe Ile Phe Asp Asp Arg Ser Leu 
            660                 665                 670         


Val Leu Thr Tyr Val Phe Thr Ile Leu Asn Cys Leu Gln Gly Ala Phe 
        675                 680                 685             


Leu Tyr Leu Leu His Cys Leu Leu Asn Lys Lys Val Arg Glu Glu Tyr 
    690                 695                 700                 


Arg Lys Trp Ala Cys Leu Val Ala Gly Gly Ser Lys Tyr Ser Glu Phe 
705                 710                 715                 720 


Thr Ser Thr Thr Ser Gly Thr Gly His Asn Gln Thr Arg Ala Leu Arg 
                725                 730                 735     


Ala Ser Glu Ser Gly Ile 
            740         


<210>  440
<211>  164
<212>  PRT
<213>  Homo Sapiens

<400>  440

Met Gly Gly Arg Val Phe Leu Ala Phe Cys Val Trp Leu Thr Leu Pro 
1               5                   10                  15      


Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp Cys Pro Gln 
            20                  25                  30          


Asn Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn Pro Gly Phe 
        35                  40                  45              


Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Thr Glu Thr Cys Asp Asp 
    50                  55                  60                  


Ile Asn Glu Cys Ala Thr Pro Ser Lys Val Ser Cys Gly Lys Phe Ser 
65                  70                  75                  80  


Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys Ser Pro Gly 
                85                  90                  95      


Tyr Glu Pro Val Ser Gly Ala Lys Thr Phe Lys Asn Glu Ser Glu Asn 
            100                 105                 110         


Thr Cys Gln Asp Val Asn Glu Cys Thr Ser Gly Gln Asn Pro Cys His 
        115                 120                 125             


Ser Ser Thr His Cys Leu Asn Asn Val Gly Ser Tyr Gln Cys Arg Cys 
    130                 135                 140                 


Arg Pro Gly Trp Gln Pro Ile Pro Gly Ser Pro Asn Gly Pro Asn Asn 
145                 150                 155                 160 


Thr Val Cys Glu 
                


<210>  441
<211>  154
<212>  PRT
<213>  Homo Sapiens

<400>  441

Met Gly Gly Arg Val Phe Leu Ala Phe Cys Val Trp Leu Thr Leu Pro 
1               5                   10                  15      


Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp Cys Pro Gln 
            20                  25                  30          


Asn Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn Pro Gly Phe 
        35                  40                  45              


Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Thr Glu Thr Cys Asp Asp 
    50                  55                  60                  


Ile Asn Glu Cys Ala Thr Pro Ser Lys Val Ser Cys Gly Lys Phe Ser 
65                  70                  75                  80  


Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys Ser Pro Gly 
                85                  90                  95      


Tyr Glu Pro Val Ser Gly Ala Lys Thr Phe Lys Asn Glu Ser Glu Asn 
            100                 105                 110         


Thr Cys Gln Gly Lys Asn His Pro Thr Ser Ser Asp Phe Pro Ser Met 
        115                 120                 125             


Arg Phe Gly Val Thr Arg Ala Ile Leu Ala Ala Ser Arg Glu Gln Gly 
    130                 135                 140                 


Leu Gly Cys Arg Val Ser Ala Trp Arg Leu 
145                 150                 


<210>  442
<211>  157
<212>  PRT
<213>  Homo Sapiens

<400>  442

Met Gly Gly Arg Val Phe Leu Gly Cys Ala Arg Trp Cys Pro Gln Asn 
1               5                   10                  15      


Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn Pro Gly Phe Ser 
            20                  25                  30          


Ser Phe Ser Glu Ile Ile Thr Thr Pro Thr Glu Thr Cys Asp Asp Ile 
        35                  40                  45              


Asn Glu Cys Ala Thr Pro Ser Lys Val Ser Cys Gly Lys Phe Ser Asp 
    50                  55                  60                  


Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys Ser Pro Gly Tyr 
65                  70                  75                  80  


Glu Pro Val Ser Gly Ala Lys Thr Phe Lys Asn Glu Ser Glu Asn Thr 
                85                  90                  95      


Cys Gln Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp Ser 
            100                 105                 110         


Ser Thr Val Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys Arg 
        115                 120                 125             


Pro Gly Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp Thr 
    130                 135                 140                 


Val Cys Glu Asp Met Thr Phe Ser Thr Trp Thr Pro Pro 
145                 150                 155         


<210>  443
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  443

Glu Tyr Gln Leu Leu Leu Gln Val Thr Tyr Arg Asp Ser Lys Glu Lys 
1               5                   10                  15      


Arg Asp Leu Arg Asn Phe Leu Lys Leu Leu Lys Pro Pro Leu Leu Trp 
            20                  25                  30          


Ser His Gly Leu Ile Arg Ile Ile Arg Ala Lys Ala Thr Thr Asp Cys 
        35                  40                  45              


Asn Ser Leu Asn Gly Val Leu Gln Cys Thr Cys Glu Asp Ser Tyr Thr 
    50                  55                  60                  


Trp Phe Pro Pro Ser Cys Leu Asp Pro Gln Asn Cys Tyr Leu His Thr 
65                  70                  75                  80  


Ala Gly Ala Leu Pro Ser Cys Glu Cys His Leu Asn Asn Leu Ser Gln 
                85                  90                  95      


Ser Val Asn Phe Cys Glu Arg Thr Lys Ile Trp Gly Thr Phe Lys Ile 
            100                 105                 110         


Asn Glu Arg Phe Thr Asn Asp Leu Leu Asn Ser Ser Ser Ala Ile Tyr 
        115                 120                 125             


Ser Lys Tyr Ala Asn Gly Ile Glu Ile Gln Leu Lys Lys Ala Tyr Glu 
    130                 135                 140                 


Arg Ile Gln Gly Phe Glu Ser Val Gln Val Thr Gln Phe Arg Pro Val 
145                 150                 155                 160 


<210>  444
<211>  713
<212>  PRT
<213>  Homo Sapiens

<400>  444

Met Asp Ile Ser Ile Gln Arg Asn Gly Ser Ile Val Ala Gly Tyr Glu 
1               5                   10                  15      


Val Val Gly Ser Ser Ser Ala Ser Glu Leu Leu Ser Ala Ile Glu His 
            20                  25                  30          


Val Ala Glu Lys Ala Lys Thr Ala Leu His Lys Leu Phe Pro Leu Glu 
        35                  40                  45              


Asp Gly Ser Phe Arg Val Phe Gly Lys Ala Gln Cys Asn Asp Ile Val 
    50                  55                  60                  


Phe Gly Phe Gly Ser Lys Asp Asp Glu Tyr Thr Leu Pro Cys Ser Ser 
65                  70                  75                  80  


Gly Tyr Arg Gly Asn Ile Thr Ala Lys Cys Glu Ser Ser Gly Trp Gln 
                85                  90                  95      


Val Ile Arg Glu Thr Cys Val Leu Ser Leu Leu Glu Glu Leu Asn Lys 
            100                 105                 110         


Asn Phe Ser Met Ile Val Gly Asn Ala Thr Glu Ala Ala Val Ser Ser 
        115                 120                 125             


Phe Val Gln Asn Leu Ser Val Ile Ile Arg Gln Asn Pro Ser Thr Thr 
    130                 135                 140                 


Val Gly Asn Leu Ala Ser Val Val Ser Ile Leu Ser Asn Ile Ser Ser 
145                 150                 155                 160 


Leu Ser Leu Ala Ser His Phe Arg Val Ser Asn Ser Thr Met Glu Asp 
                165                 170                 175     


Val Ile Ser Ile Ala Asp Asn Ile Leu Asn Ser Ala Ser Val Thr Asn 
            180                 185                 190         


Trp Thr Val Leu Leu Arg Glu Glu Lys Tyr Ala Ser Ser Arg Leu Leu 
        195                 200                 205             


Glu Thr Leu Glu Asn Ile Ser Thr Leu Val Pro Pro Thr Ala Leu Pro 
    210                 215                 220                 


Leu Asn Phe Ser Arg Lys Phe Ile Asp Trp Lys Gly Ile Pro Val Asn 
225                 230                 235                 240 


Lys Ser Gln Leu Lys Arg Gly Tyr Ser Tyr Gln Ile Lys Met Cys Pro 
                245                 250                 255     


Gln Asn Thr Ser Ile Pro Ile Arg Gly Arg Val Leu Ile Gly Ser Asp 
            260                 265                 270         


Gln Phe Gln Arg Ser Leu Pro Glu Thr Ile Ile Ser Met Ala Ser Leu 
        275                 280                 285             


Thr Leu Gly Asn Ile Leu Pro Val Ser Lys Asn Gly Asn Ala Gln Val 
    290                 295                 300                 


Asn Gly Pro Val Ile Ser Thr Val Ile Gln Asn Tyr Ser Ile Asn Glu 
305                 310                 315                 320 


Val Phe Leu Phe Phe Ser Lys Ile Glu Ser Asn Leu Ser Gln Pro His 
                325                 330                 335     


Cys Val Phe Trp Asp Phe Ser His Leu Gln Trp Asn Asp Ala Gly Cys 
            340                 345                 350         


His Leu Val Asn Glu Thr Gln Asp Ile Val Thr Cys Gln Cys Thr His 
        355                 360                 365             


Leu Thr Ser Phe Ser Ile Leu Met Ser Pro Phe Val Pro Ser Thr Ile 
    370                 375                 380                 


Phe Pro Val Val Lys Trp Ile Thr Tyr Val Gly Leu Gly Ile Ser Ile 
385                 390                 395                 400 


Gly Ser Leu Ile Leu Cys Leu Ile Ile Glu Ala Leu Phe Trp Lys Gln 
                405                 410                 415     


Ile Lys Lys Ser Gln Thr Ser His Thr Arg Arg Ile Cys Met Val Asn 
            420                 425                 430         


Ile Ala Leu Ser Leu Leu Ile Ala Asp Val Trp Phe Ile Val Gly Ala 
        435                 440                 445             


Thr Val Asp Thr Thr Val Asn Pro Ser Gly Val Cys Thr Ala Ala Val 
    450                 455                 460                 


Phe Phe Thr His Phe Phe Tyr Leu Ser Leu Phe Phe Trp Met Leu Met 
465                 470                 475                 480 


Leu Gly Ile Leu Leu Ala Tyr Arg Ile Ile Leu Val Phe His His Met 
                485                 490                 495     


Ala Gln His Leu Met Met Ala Val Gly Phe Cys Leu Gly Tyr Gly Cys 
            500                 505                 510         


Pro Leu Ile Ile Ser Val Ile Thr Ile Ala Val Thr Gln Pro Ser Asn 
        515                 520                 525             


Thr Tyr Lys Arg Lys Asp Val Cys Trp Leu Asn Trp Ser Asn Gly Ser 
    530                 535                 540                 


Lys Pro Leu Leu Ala Phe Val Val Pro Ala Leu Ala Ile Val Ala Val 
545                 550                 555                 560 


Asn Phe Val Val Val Leu Leu Val Leu Thr Lys Leu Trp Arg Pro Thr 
                565                 570                 575     


Val Gly Glu Arg Leu Ser Arg Asp Asp Lys Ala Thr Ile Ile Arg Val 
            580                 585                 590         


Gly Lys Ser Leu Leu Ile Leu Thr Pro Leu Leu Gly Leu Thr Trp Gly 
        595                 600                 605             


Phe Gly Ile Gly Thr Ile Val Asp Ser Gln Asn Leu Ala Trp His Val 
    610                 615                 620                 


Ile Phe Ala Leu Leu Asn Ala Phe Gln Gly Phe Phe Ile Leu Cys Phe 
625                 630                 635                 640 


Gly Ile Leu Leu Asp Ser Lys Leu Arg Gln Leu Leu Phe Asn Lys Leu 
                645                 650                 655     


Ser Ala Leu Ser Ser Trp Lys Gln Thr Glu Lys Gln Asn Ser Ser Asp 
            660                 665                 670         


Leu Ser Ala Lys Pro Lys Phe Ser Lys Pro Phe Asn Pro Leu Gln Asn 
        675                 680                 685             


Lys Gly His Tyr Ala Phe Ser His Thr Gly Asp Ser Ser Asp Asn Ile 
    690                 695                 700                 


Met Leu Thr Gln Phe Val Ser Asn Glu 
705                 710             


<210>  445
<211>  218
<212>  PRT
<213>  Homo Sapiens

<400>  445

Met Lys Val Gly Val Leu Trp Leu Ile Ser Phe Phe Thr Phe Thr Asp 
1               5                   10                  15      


Gly His Gly Gly Phe Leu Gly Lys Asn Asp Gly Ile Lys Thr Lys Lys 
            20                  25                  30          


Glu Leu Ile Val Asn Lys Lys Lys His Leu Gly Pro Val Glu Glu Tyr 
        35                  40                  45              


Gln Leu Leu Leu Gln Val Thr Tyr Arg Asp Ser Lys Glu Lys Arg Asp 
    50                  55                  60                  


Leu Arg Asn Phe Leu Lys Leu Leu Lys Pro Pro Leu Leu Trp Ser His 
65                  70                  75                  80  


Gly Leu Ile Arg Ile Ile Arg Ala Lys Ala Thr Thr Asp Cys Asn Ser 
                85                  90                  95      


Leu Asn Gly Val Leu Gln Cys Thr Cys Glu Asp Ser Tyr Thr Trp Phe 
            100                 105                 110         


Pro Pro Ser Cys Leu Asp Pro Gln Asn Cys Tyr Leu His Thr Ala Gly 
        115                 120                 125             


Ala Leu Pro Ser Cys Glu Cys His Leu Asn Asn Leu Ser Gln Ser Val 
    130                 135                 140                 


Asn Phe Cys Glu Arg Thr Lys Ile Trp Gly Thr Phe Lys Ile Asn Glu 
145                 150                 155                 160 


Arg Phe Thr Asn Asp Leu Leu Asn Ser Ser Ser Ala Ile Tyr Ser Lys 
                165                 170                 175     


Tyr Ala Asn Gly Ile Glu Ile Gln Leu Lys Lys Ala Tyr Glu Arg Ile 
            180                 185                 190         


Gln Gly Phe Glu Ser Val Gln Val Thr Gln Phe Arg Met Ser Leu Leu 
        195                 200                 205             


Ser Pro Lys Leu Glu Cys Asn Gly Thr Ile 
    210                 215             


<210>  446
<211>  910
<212>  PRT
<213>  Homo Sapiens

<400>  446

Met Lys Val Gly Val Leu Trp Leu Ile Ser Phe Phe Thr Phe Thr Asp 
1               5                   10                  15      


Gly His Gly Gly Phe Leu Gly Lys Asn Asp Gly Ile Lys Thr Lys Lys 
            20                  25                  30          


Glu Leu Ile Val Asn Lys Lys Lys His Leu Gly Pro Val Glu Glu Tyr 
        35                  40                  45              


Gln Leu Leu Leu Gln Val Thr Tyr Arg Asp Ser Lys Glu Lys Arg Asp 
    50                  55                  60                  


Leu Arg Asn Phe Leu Lys Leu Leu Lys Pro Pro Leu Leu Trp Ser His 
65                  70                  75                  80  


Gly Leu Ile Arg Ile Ile Arg Ala Lys Ala Thr Thr Asp Cys Asn Ser 
                85                  90                  95      


Leu Asn Gly Val Leu Gln Cys Thr Cys Glu Asp Ser Tyr Thr Trp Phe 
            100                 105                 110         


Pro Pro Ser Cys Leu Asp Pro Gln Asn Cys Tyr Leu His Thr Ala Gly 
        115                 120                 125             


Ala Leu Pro Ser Cys Glu Cys His Leu Asn Asn Leu Ser Gln Ser Val 
    130                 135                 140                 


Asn Phe Cys Glu Arg Thr Lys Ile Trp Gly Thr Phe Lys Ile Asn Glu 
145                 150                 155                 160 


Arg Phe Thr Asn Asp Leu Leu Asn Ser Ser Ser Ala Ile Tyr Ser Lys 
                165                 170                 175     


Tyr Ala Asn Gly Ile Glu Ile Gln Leu Lys Lys Ala Tyr Glu Arg Ile 
            180                 185                 190         


Gln Gly Phe Glu Ser Val Gln Val Thr Gln Phe Arg Asn Gly Ser Ile 
        195                 200                 205             


Val Ala Gly Tyr Glu Val Val Gly Ser Ser Ser Ala Ser Glu Leu Leu 
    210                 215                 220                 


Ser Ala Ile Glu His Val Ala Glu Lys Ala Lys Thr Ala Leu His Lys 
225                 230                 235                 240 


Leu Phe Pro Leu Glu Asp Gly Ser Phe Arg Val Phe Gly Lys Ala Gln 
                245                 250                 255     


Cys Asn Asp Ile Val Phe Gly Phe Gly Ser Lys Asp Asp Glu Tyr Thr 
            260                 265                 270         


Leu Pro Cys Ser Ser Gly Tyr Arg Gly Asn Ile Thr Ala Lys Cys Glu 
        275                 280                 285             


Ser Ser Gly Trp Gln Val Ile Arg Glu Thr Cys Val Leu Ser Leu Leu 
    290                 295                 300                 


Glu Glu Leu Asn Lys Asn Phe Ser Met Ile Val Gly Asn Ala Thr Glu 
305                 310                 315                 320 


Ala Ala Val Ser Ser Phe Val Gln Asn Leu Ser Val Ile Ile Arg Gln 
                325                 330                 335     


Asn Pro Ser Thr Thr Val Gly Asn Leu Ala Ser Val Val Ser Ile Leu 
            340                 345                 350         


Ser Asn Ile Ser Ser Leu Ser Leu Ala Ser His Phe Arg Val Ser Asn 
        355                 360                 365             


Ser Thr Met Glu Asp Val Ile Ser Ile Ala Asp Asn Ile Leu Asn Ser 
    370                 375                 380                 


Ala Ser Val Thr Asn Trp Thr Val Leu Leu Arg Glu Glu Lys Tyr Ala 
385                 390                 395                 400 


Ser Ser Arg Leu Leu Glu Thr Leu Glu Asn Ile Ser Thr Leu Val Pro 
                405                 410                 415     


Pro Thr Ala Leu Pro Leu Asn Phe Ser Arg Lys Phe Ile Asp Trp Lys 
            420                 425                 430         


Gly Ile Pro Val Asn Lys Ser Gln Leu Lys Arg Gly Tyr Ser Tyr Gln 
        435                 440                 445             


Ile Lys Met Cys Pro Gln Asn Thr Ser Ile Pro Ile Arg Gly Arg Val 
    450                 455                 460                 


Leu Ile Gly Ser Asp Gln Phe Gln Arg Ser Leu Pro Glu Thr Ile Ile 
465                 470                 475                 480 


Ser Met Ala Ser Leu Thr Leu Gly Asn Ile Leu Pro Val Ser Lys Asn 
                485                 490                 495     


Gly Asn Ala Gln Val Asn Gly Pro Val Ile Ser Thr Val Ile Gln Asn 
            500                 505                 510         


Tyr Ser Ile Asn Glu Val Phe Leu Phe Phe Ser Lys Ile Glu Ser Asn 
        515                 520                 525             


Leu Ser Gln Pro His Cys Val Phe Trp Asp Phe Ser His Leu Gln Trp 
    530                 535                 540                 


Asn Asp Ala Gly Cys His Leu Val Asn Glu Thr Gln Asp Ile Val Thr 
545                 550                 555                 560 


Cys Gln Cys Thr His Leu Thr Ser Phe Ser Ile Leu Met Ser Pro Phe 
                565                 570                 575     


Val Pro Ser Thr Ile Phe Pro Val Val Lys Trp Ile Thr Tyr Val Gly 
            580                 585                 590         


Leu Gly Ile Ser Ile Gly Ser Leu Ile Leu Cys Leu Ile Ile Glu Ala 
        595                 600                 605             


Leu Phe Trp Lys Gln Ile Lys Lys Ser Gln Thr Ser His Thr Arg Arg 
    610                 615                 620                 


Ile Cys Met Val Asn Ile Ala Leu Ser Leu Leu Ile Ala Asp Val Trp 
625                 630                 635                 640 


Phe Ile Val Gly Ala Thr Val Asp Thr Thr Val Asn Pro Ser Gly Val 
                645                 650                 655     


Cys Thr Ala Ala Val Phe Phe Thr His Phe Phe Tyr Leu Ser Leu Phe 
            660                 665                 670         


Phe Trp Met Leu Met Leu Gly Ile Leu Leu Ala Tyr Arg Ile Ile Leu 
        675                 680                 685             


Val Phe His His Met Ala Gln His Leu Met Met Ala Val Gly Phe Cys 
    690                 695                 700                 


Leu Gly Tyr Gly Cys Pro Leu Ile Ile Ser Val Ile Thr Ile Ala Val 
705                 710                 715                 720 


Thr Gln Pro Ser Asn Thr Tyr Lys Arg Lys Asp Val Cys Trp Leu Asn 
                725                 730                 735     


Trp Ser Asn Gly Ser Lys Pro Leu Leu Ala Phe Val Val Pro Ala Leu 
            740                 745                 750         


Ala Ile Val Ala Val Asn Phe Val Val Val Leu Leu Val Leu Thr Lys 
        755                 760                 765             


Leu Trp Arg Pro Thr Val Gly Glu Arg Leu Ser Arg Asp Asp Lys Ala 
    770                 775                 780                 


Thr Ile Ile Arg Val Gly Lys Ser Leu Leu Ile Leu Thr Pro Leu Leu 
785                 790                 795                 800 


Gly Leu Thr Trp Gly Phe Gly Ile Gly Thr Ile Val Asp Ser Gln Asn 
                805                 810                 815     


Leu Ala Trp His Val Ile Phe Ala Leu Leu Asn Ala Phe Gln Gly Phe 
            820                 825                 830         


Phe Ile Leu Cys Phe Gly Ile Leu Leu Asp Ser Lys Leu Arg Gln Leu 
        835                 840                 845             


Leu Phe Asn Lys Leu Ser Ala Leu Ser Ser Trp Lys Gln Thr Glu Lys 
    850                 855                 860                 


Gln Asn Ser Ser Asp Leu Ser Ala Lys Pro Lys Phe Ser Lys Pro Phe 
865                 870                 875                 880 


Asn Pro Leu Gln Asn Lys Gly His Tyr Ala Phe Ser His Thr Gly Asp 
                885                 890                 895     


Ser Ser Asp Asn Ile Met Leu Thr Gln Phe Val Ser Asn Glu 
            900                 905                 910 


<210>  447
<211>  137
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  447

Xaa Trp Ser His Gly Leu Ile Arg Ile Ile Arg Ala Lys Ala Thr Thr 
1               5                   10                  15      


Asp Cys Asn Ser Leu Asn Gly Val Leu Gln Cys Thr Cys Glu Asp Ser 
            20                  25                  30          


Tyr Thr Trp Phe Pro Pro Ser Cys Leu Asp Pro Gln Asn Cys Tyr Leu 
        35                  40                  45              


His Thr Ala Gly Ala Leu Pro Ser Cys Glu Cys His Leu Asn Asn Leu 
    50                  55                  60                  


Ser Gln Ser Val Asn Phe Cys Glu Arg Thr Lys Ile Trp Gly Thr Phe 
65                  70                  75                  80  


Lys Ile Asn Glu Arg Phe Thr Asn Asp Leu Leu Asn Ser Ser Ser Ala 
                85                  90                  95      


Ile Tyr Ser Lys Tyr Ala Asn Gly Ile Glu Ile Gln Leu Lys Lys Ala 
            100                 105                 110         


Tyr Glu Arg Ile Gln Gly Phe Glu Ser Val Gln Val Thr Gln Phe Arg 
        115                 120                 125             


Thr Val Ile His Leu Trp Asn Leu Val 
    130                 135         


<210>  448
<211>  6
<212>  PRT
<213>  Homo Sapiens

<400>  448

Met Thr Pro Gln Ser Leu 
1               5       


<210>  449
<211>  95
<212>  PRT
<213>  Homo Sapiens

<400>  449

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala His Pro Ala Ser Arg Ser Phe Pro Asp Pro 
            20                  25                  30          


Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg His Ala Gly Arg 
        35                  40                  45              


Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu Ser Asp Lys Ala 
    50                  55                  60                  


Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser Leu Ala Gln Gly 
65                  70                  75                  80  


Pro Pro Leu Leu Ala Thr Ser Val Thr Ser Trp Trp Ser Pro Gln 
                85                  90                  95  


<210>  450
<211>  125
<212>  PRT
<213>  Homo Sapiens

<400>  450

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala His Pro Ala Ser Arg Ser Phe Pro Asp Pro 
            20                  25                  30          


Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg His Ala Gly Arg 
        35                  40                  45              


Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu Ser Asp Lys Ala 
    50                  55                  60                  


Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser Leu Ala Gln Gly 
65                  70                  75                  80  


Pro Pro Leu Leu Ala Thr Ser Val Thr Ser Trp Trp Ser Pro Gln Asn 
                85                  90                  95      


Ile Ser Leu Pro Ser Ala Ala Ser Phe Thr Phe Ser Phe His Ser Pro 
            100                 105                 110         


Pro His Thr Ala Ala His Asn Ala Ser Val Asp Met Cys 
        115                 120                 125 


<210>  451
<211>  90
<212>  PRT
<213>  Homo Sapiens

<400>  451

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala Pro Ala Thr Gly Ser His Leu Gln Pro Leu 
            20                  25                  30          


Pro Pro Gln Val Pro Thr Ala Gly Ala Thr Gly Lys Thr Phe Ala Ser 
        35                  40                  45              


Ala Ala Ser Gly Thr Arg His Thr Gly Ala Ala Ser Thr Thr Asn Pro 
    50                  55                  60                  


His Gln Thr Cys Ala Ser Pro Ser Arg Thr Pro Lys Arg Pro Ser Gln 
65                  70                  75                  80  


Ser Met Pro Leu Ser Leu Gln Pro Thr Leu 
                85                  90  


<210>  452
<211>  118
<212>  PRT
<213>  Homo Sapiens

<400>  452

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala Pro Ala Thr Gly Ser His Leu Gln Pro Leu 
            20                  25                  30          


Pro Pro Gln Val Pro Thr Ala Gly Ala Thr Gly Lys Thr Phe Ala Ser 
        35                  40                  45              


Ala Ala Ser Gly Thr Arg His Thr Gly Ala Ala Ser Thr Thr Asn Pro 
    50                  55                  60                  


His Gln Thr Cys Ala Ser Pro Ser Arg Thr Pro Lys Arg Pro Ser Gln 
65                  70                  75                  80  


Ser Met Pro Leu Ser Leu Gln Pro Thr Leu Leu Pro Asp Pro Ser Leu 
                85                  90                  95      


Thr Pro Gly Ala Ser Thr Thr Ser Ala Ser Thr Gly Thr Asp Met Leu 
            100                 105                 110         


Gly Asp Tyr Ile Phe Ser 
        115             


<210>  453
<211>  91
<212>  PRT
<213>  Homo Sapiens

<400>  453

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala Ser Ala Ser Ser Gly Ala His Gly Arg Gly 
            20                  25                  30          


His Arg Glu Asp Phe Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg 
        35                  40                  45              


Ser Ser Leu His Tyr Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu 
    50                  55                  60                  


Asn Ser Glu Glu Ala Leu Thr Val His Ala Pro Phe Pro Ala Ala His 
65                  70                  75                  80  


Pro Ala Ser Arg Ser Phe Pro Asp Pro Arg Gly 
                85                  90      


<210>  454
<211>  98
<212>  PRT
<213>  Homo Sapiens

<400>  454

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala Ser Ala Ser Ser Gly Ala His Gly Arg Gly 
            20                  25                  30          


His Arg Glu Asp Phe Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg 
        35                  40                  45              


Ser Ser Leu His Tyr Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu 
    50                  55                  60                  


Asn Ser Glu Glu Ala Leu Thr Val His Ala Pro Phe Pro Ala Ala His 
65                  70                  75                  80  


Pro Ala Ser Arg Ser Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys 
                85                  90                  95      


Leu Tyr 
        


<210>  455
<211>  103
<212>  PRT
<213>  Homo Sapiens

<400>  455

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala Ser Ala Ser Ser Gly Ala His Gly Arg Gly 
            20                  25                  30          


His Arg Glu Asp Phe Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg 
        35                  40                  45              


Ser Ser Leu His Tyr Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu 
    50                  55                  60                  


Asn Ser Glu Glu Ala Leu Thr Val His Ala Pro Phe Pro Ala Ala His 
65                  70                  75                  80  


Pro Ala Ser Arg Ser Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys 
                85                  90                  95      


Leu Tyr Trp Asn Arg His Ala 
            100             


<210>  456
<211>  114
<212>  PRT
<213>  Homo Sapiens

<400>  456

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala Ser Ala Ser Ser Gly Ala His Gly Arg Gly 
            20                  25                  30          


His Arg Glu Asp Phe Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg 
        35                  40                  45              


Ser Ser Leu His Tyr Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu 
    50                  55                  60                  


Asn Ser Glu Glu Ala Leu Thr Val His Ala Pro Phe Pro Ala Ala His 
65                  70                  75                  80  


Pro Ala Ser Arg Ser Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys 
                85                  90                  95      


Leu Tyr Trp Asn Arg His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys 
            100                 105                 110         


Arg Asp 
        


<210>  457
<211>  118
<212>  PRT
<213>  Homo Sapiens

<400>  457

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala Ser Ala Ser Ser Gly Ala His Gly Arg Gly 
            20                  25                  30          


His Arg Glu Asp Phe Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg 
        35                  40                  45              


Ser Ser Leu His Tyr Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu 
    50                  55                  60                  


Asn Ser Glu Glu Ala Leu Thr Val His Ala Pro Phe Pro Ala Ala His 
65                  70                  75                  80  


Pro Ala Ser Arg Ser Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys 
                85                  90                  95      


Leu Tyr Trp Asn Arg His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys 
            100                 105                 110         


Arg Asp Phe Leu Leu Ser 
        115             


<210>  458
<211>  118
<212>  PRT
<213>  Homo Sapiens

<400>  458

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala Ser Ala Ser Ser Gly Ala His Gly Arg Gly 
            20                  25                  30          


His Arg Glu Asp Phe Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg 
        35                  40                  45              


Ser Ser Leu His Tyr Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu 
    50                  55                  60                  


Asn Ser Glu Glu Ala Leu Thr Val His Ala Pro Phe Pro Ala Ala His 
65                  70                  75                  80  


Pro Ala Ser Arg Ser Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys 
                85                  90                  95      


Leu Tyr Trp Asn Arg His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys 
            100                 105                 110         


Arg Asp Phe Leu Leu Ser 
        115             


<210>  459
<211>  125
<212>  PRT
<213>  Homo Sapiens

<400>  459

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala Ser Ala Ser Ser Gly Ala His Gly Arg Gly 
            20                  25                  30          


His Arg Glu Asp Phe Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg 
        35                  40                  45              


Ser Ser Leu His Tyr Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu 
    50                  55                  60                  


Asn Ser Glu Glu Ala Leu Thr Val His Ala Pro Phe Pro Ala Ala His 
65                  70                  75                  80  


Pro Ala Ser Arg Ser Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys 
                85                  90                  95      


Leu Tyr Trp Asn Arg His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys 
            100                 105                 110         


Arg Asp Phe Leu Leu Ser Asp Lys Ala Ser Ser Leu Leu 
        115                 120                 125 


<210>  460
<211>  145
<212>  PRT
<213>  Homo Sapiens

<400>  460

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala Ser Ala Ser Ser Gly Ala His Gly Arg Gly 
            20                  25                  30          


His Arg Glu Asp Phe Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg 
        35                  40                  45              


Ser Ser Leu His Tyr Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu 
    50                  55                  60                  


Asn Ser Glu Glu Ala Leu Thr Val His Ala Pro Phe Pro Ala Ala His 
65                  70                  75                  80  


Pro Ala Ser Arg Ser Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys 
                85                  90                  95      


Leu Tyr Trp Asn Arg His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys 
            100                 105                 110         


Arg Asp Phe Leu Leu Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln 
        115                 120                 125             


His Gln Glu Glu Ser Leu Ala Gln Gly Pro Pro Leu Leu Ala Thr Ser 
    130                 135                 140                 


Val 
145 


<210>  461
<211>  146
<212>  PRT
<213>  Homo Sapiens

<400>  461

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala Ser Ala Ser Ser Gly Ala His Gly Arg Gly 
            20                  25                  30          


His Arg Glu Asp Phe Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg 
        35                  40                  45              


Ser Ser Leu His Tyr Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu 
    50                  55                  60                  


Asn Ser Glu Glu Ala Leu Thr Val His Ala Pro Phe Pro Ala Ala His 
65                  70                  75                  80  


Pro Ala Ser Arg Ser Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys 
                85                  90                  95      


Leu Tyr Trp Asn Arg His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys 
            100                 105                 110         


Arg Asp Phe Leu Leu Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln 
        115                 120                 125             


His Gln Glu Glu Ser Leu Ala Gln Gly Pro Pro Leu Leu Ala Thr Ser 
    130                 135                 140                 


Val Thr 
145     


<210>  462
<211>  164
<212>  PRT
<213>  Homo Sapiens

<400>  462

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala Ser Ala Ser Ser Gly Ala His Gly Arg Gly 
            20                  25                  30          


His Arg Glu Asp Phe Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg 
        35                  40                  45              


Ser Ser Leu His Tyr Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu 
    50                  55                  60                  


Asn Ser Glu Glu Ala Leu Thr Val His Ala Pro Phe Pro Ala Ala His 
65                  70                  75                  80  


Pro Ala Ser Arg Ser Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys 
                85                  90                  95      


Leu Tyr Trp Asn Arg His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys 
            100                 105                 110         


Arg Asp Phe Leu Leu Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln 
        115                 120                 125             


His Gln Glu Glu Ser Leu Ala Gln Gly Pro Pro Leu Leu Ala Thr Ser 
    130                 135                 140                 


Val Thr Ser Trp Trp Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala Ala 
145                 150                 155                 160 


Ser Phe Thr Phe 
                


<210>  463
<211>  168
<212>  PRT
<213>  Homo Sapiens

<400>  463

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala Ser Ala Ser Ser Gly Ala His Gly Arg Gly 
            20                  25                  30          


His Arg Glu Asp Phe Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg 
        35                  40                  45              


Ser Ser Leu His Tyr Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu 
    50                  55                  60                  


Asn Ser Glu Glu Ala Leu Thr Val His Ala Pro Phe Pro Ala Ala His 
65                  70                  75                  80  


Pro Ala Ser Arg Ser Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys 
                85                  90                  95      


Leu Tyr Trp Asn Arg His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys 
            100                 105                 110         


Arg Asp Phe Leu Leu Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln 
        115                 120                 125             


His Gln Glu Glu Ser Leu Ala Gln Gly Pro Pro Leu Leu Ala Thr Ser 
    130                 135                 140                 


Val Thr Ser Trp Trp Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala Ala 
145                 150                 155                 160 


Ser Phe Thr Phe Ser Phe His Ser 
                165             


<210>  464
<211>  198
<212>  PRT
<213>  Homo Sapiens

<400>  464

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala Ser Ala Ser Ser Gly Ala His Gly Arg Gly 
            20                  25                  30          


His Arg Glu Asp Phe Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg 
        35                  40                  45              


Ser Ser Leu His Tyr Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu 
    50                  55                  60                  


Asn Ser Glu Glu Ala Leu Thr Val His Ala Pro Phe Pro Ala Ala His 
65                  70                  75                  80  


Pro Ala Ser Arg Ser Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys 
                85                  90                  95      


Leu Tyr Trp Asn Arg His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys 
            100                 105                 110         


Arg Asp Phe Leu Leu Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln 
        115                 120                 125             


His Gln Glu Glu Ser Leu Ala Gln Gly Pro Pro Leu Leu Ala Thr Ser 
    130                 135                 140                 


Val Thr Ser Trp Trp Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala Ala 
145                 150                 155                 160 


Ser Phe Thr Phe Ser Phe His Ser Pro Pro His Thr Ala Ala His Asn 
                165                 170                 175     


Ala Ser Val Asp Met Cys Glu Leu Lys Arg Asp Leu Gln Leu Leu Ser 
            180                 185                 190         


Gln Phe Leu Lys His Pro 
        195             


<210>  465
<211>  692
<212>  PRT
<213>  Homo Sapiens

<400>  465

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala Ser Ala Ser Ser Gly Ala His Gly Arg Gly 
            20                  25                  30          


His Arg Glu Asp Phe Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg 
        35                  40                  45              


Ser Ser Leu His Tyr Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu 
    50                  55                  60                  


Asn Ser Glu Glu Ala Leu Thr Val His Ala Pro Phe Pro Ala Ala His 
65                  70                  75                  80  


Pro Ala Ser Arg Ser Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys 
                85                  90                  95      


Leu Tyr Trp Asn Arg His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys 
            100                 105                 110         


Arg Asp Phe Leu Leu Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln 
        115                 120                 125             


His Gln Glu Glu Ser Leu Ala Gln Gly Pro Pro Leu Leu Ala Thr Ser 
    130                 135                 140                 


Val Thr Ser Trp Trp Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala Ala 
145                 150                 155                 160 


Ser Phe Thr Phe Ser Phe His Ser Pro Pro His Thr Ala Ala His Asn 
                165                 170                 175     


Ala Ser Val Asp Met Cys Glu Leu Lys Arg Asp Leu Gln Leu Leu Ser 
            180                 185                 190         


Gln Phe Leu Lys His Pro Gln Lys Ala Ser Arg Arg Pro Ser Ala Ala 
        195                 200                 205             


Pro Ala Ser Gln Gln Leu Gln Ser Leu Glu Ser Lys Leu Thr Ser Val 
    210                 215                 220                 


Arg Phe Met Gly Asp Met Val Ser Phe Glu Glu Asp Arg Ile Asn Ala 
225                 230                 235                 240 


Thr Val Trp Lys Leu Gln Pro Thr Ala Gly Leu Gln Asp Leu His Ile 
                245                 250                 255     


His Ser Arg Gln Glu Glu Glu Gln Ser Glu Ile Met Glu Tyr Ser Val 
            260                 265                 270         


Leu Leu Pro Arg Thr Leu Phe Gln Arg Thr Lys Gly Arg Ser Gly Glu 
        275                 280                 285             


Ala Glu Lys Arg Leu Leu Leu Val Asp Phe Ser Ser Gln Ala Leu Phe 
    290                 295                 300                 


Gln Asp Lys Asn Ser Ser Gln Val Leu Gly Glu Lys Val Leu Gly Ile 
305                 310                 315                 320 


Val Val Gln Asn Thr Lys Val Ala Asn Leu Thr Glu Pro Val Val Leu 
                325                 330                 335     


Thr Phe Gln His Gln Leu Gln Pro Lys Asn Val Thr Leu Gln Cys Val 
            340                 345                 350         


Phe Trp Val Glu Asp Pro Thr Leu Ser Ser Pro Gly His Trp Ser Ser 
        355                 360                 365             


Ala Gly Cys Glu Thr Val Arg Arg Glu Thr Gln Thr Ser Cys Phe Cys 
    370                 375                 380                 


Asn His Leu Thr Tyr Phe Ala Val Leu Met Val Ser Ser Val Glu Val 
385                 390                 395                 400 


Asp Ala Val His Lys His Tyr Leu Ser Leu Leu Ser Tyr Val Gly Cys 
                405                 410                 415     


Val Val Ser Ala Leu Ala Cys Leu Val Thr Ile Ala Ala Tyr Leu Cys 
            420                 425                 430         


Ser Arg Arg Lys Pro Arg Asp Tyr Thr Ile Lys Val His Met Asn Leu 
        435                 440                 445             


Leu Leu Ala Val Phe Leu Leu Asp Thr Ser Phe Leu Leu Ser Glu Pro 
    450                 455                 460                 


Val Ala Leu Thr Gly Ser Glu Ala Gly Cys Arg Ala Ser Ala Ile Phe 
465                 470                 475                 480 


Leu His Phe Ser Leu Leu Thr Cys Leu Ser Trp Met Gly Leu Glu Gly 
                485                 490                 495     


Tyr Asn Leu Tyr Arg Leu Val Val Glu Val Phe Gly Thr Tyr Val Pro 
            500                 505                 510         


Gly Tyr Leu Leu Lys Leu Ser Ala Met Gly Trp Gly Phe Pro Ile Phe 
        515                 520                 525             


Leu Val Thr Leu Val Ala Leu Val Asp Val Asp Asn Tyr Gly Pro Ile 
    530                 535                 540                 


Ile Leu Ala Val His Arg Thr Pro Glu Gly Val Ile Tyr Pro Ser Met 
545                 550                 555                 560 


Cys Trp Ile Arg Asp Ser Leu Val Ser Tyr Ile Thr Asn Leu Gly Leu 
                565                 570                 575     


Phe Ser Leu Val Phe Leu Phe Asn Met Ala Met Leu Ala Thr Met Val 
            580                 585                 590         


Val Gln Ile Leu Arg Leu Arg Pro His Thr Gln Lys Trp Ser His Val 
        595                 600                 605             


Leu Thr Leu Leu Gly Leu Ser Leu Val Leu Gly Leu Pro Trp Ala Leu 
    610                 615                 620                 


Ile Phe Phe Ser Phe Ala Ser Gly Thr Phe Gln Leu Val Val Leu Tyr 
625                 630                 635                 640 


Leu Phe Ser Ile Ile Thr Ser Phe Gln Gly Phe Leu Ile Phe Ile Trp 
                645                 650                 655     


Tyr Trp Ser Met Arg Leu Gln Ala Arg Gly Gly Pro Ser Pro Leu Lys 
            660                 665                 670         


Ser Asn Ser Asp Ser Ala Arg Leu Pro Ile Ser Ser Gly Ser Thr Ser 
        675                 680                 685             


Ser Ser Arg Ile 
    690         


<210>  466
<211>  97
<212>  PRT
<213>  Homo Sapiens

<400>  466

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala Ser Gly Thr Arg His Thr Gly Ala Ala Ser 
            20                  25                  30          


Thr Thr Asn Pro His Gln Thr Cys Ala Ser Pro Ser Arg Thr Pro Lys 
        35                  40                  45              


Arg Pro Ser Gln Ser Met Pro Leu Ser Leu Gln Pro Thr Leu Leu Pro 
    50                  55                  60                  


Asp Pro Ser Leu Thr Pro Gly Ala Ser Thr Thr Ser Ala Ser Thr Gly 
65                  70                  75                  80  


Thr Asp Met Leu Gly Asp Tyr Ile Phe Ser Met Ala Ser Val Thr Ser 
                85                  90                  95      


Cys 
    


<210>  467
<211>  97
<212>  PRT
<213>  Homo Sapiens

<400>  467

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala Ser Gly Thr Arg His Thr Gly Ala Ala Ser 
            20                  25                  30          


Thr Thr Asn Pro His Gln Thr Cys Ala Ser Pro Ser Arg Thr Pro Lys 
        35                  40                  45              


Arg Pro Ser Gln Ser Met Pro Leu Ser Leu Gln Pro Thr Leu Leu Pro 
    50                  55                  60                  


Asp Pro Ser Leu Thr Pro Gly Ala Ser Thr Thr Ser Ala Ser Thr Gly 
65                  70                  75                  80  


Thr Asp Met Leu Gly Asp Tyr Ile Phe Ser Met Ala Ser Val Thr Ser 
                85                  90                  95      


Cys 
    


<210>  468
<211>  97
<212>  PRT
<213>  Homo Sapiens

<400>  468

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala Ser Gly Thr Arg His Thr Gly Ala Ala Ser 
            20                  25                  30          


Thr Thr Asn Pro His Gln Thr Cys Ala Ser Pro Ser Arg Thr Pro Lys 
        35                  40                  45              


Arg Pro Ser Gln Ser Met Pro Leu Ser Leu Gln Pro Thr Leu Leu Pro 
    50                  55                  60                  


Asp Pro Ser Leu Thr Pro Gly Ala Ser Thr Thr Ser Ala Ser Thr Gly 
65                  70                  75                  80  


Thr Asp Met Leu Gly Asp Tyr Ile Phe Ser Met Ala Ser Val Thr Ser 
                85                  90                  95      


Cys 
    


<210>  469
<211>  68
<212>  PRT
<213>  Homo Sapiens

<400>  469

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Ala Ser Ser Leu Leu Cys Phe Gln His Gln Glu 
            20                  25                  30          


Glu Ser Leu Ala Gln Gly Pro Pro Leu Leu Ala Thr Ser Val Thr Ser 
        35                  40                  45              


Trp Trp Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala Ala Ser Phe Thr 
    50                  55                  60                  


Phe Ser Phe His 
65              


<210>  470
<211>  42
<212>  PRT
<213>  Homo Sapiens

<400>  470

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His 
        35                  40          


<210>  471
<211>  50
<212>  PRT
<213>  Homo Sapiens

<400>  471

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro 
    50  


<210>  472
<211>  55
<212>  PRT
<213>  Homo Sapiens

<400>  472

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg 
    50                  55  


<210>  473
<211>  56
<212>  PRT
<213>  Homo Sapiens

<400>  473

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile 
    50                  55      


<210>  474
<211>  70
<212>  PRT
<213>  Homo Sapiens

<400>  474

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro 
65                  70  


<210>  475
<211>  77
<212>  PRT
<213>  Homo Sapiens

<400>  475

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala 
65                  70                  75          


<210>  476
<211>  84
<212>  PRT
<213>  Homo Sapiens

<400>  476

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro 
                


<210>  477
<211>  84
<212>  PRT
<213>  Homo Sapiens

<400>  477

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro 
                


<210>  478
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  478

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp 
                85                  90                  


<210>  479
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  479

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp 
                85                  90                  


<210>  480
<211>  100
<212>  PRT
<213>  Homo Sapiens

<400>  480

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg 
            100 


<210>  481
<211>  107
<212>  PRT
<213>  Homo Sapiens

<400>  481

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys 
            100                 105         


<210>  482
<211>  110
<212>  PRT
<213>  Homo Sapiens

<400>  482

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe 
            100                 105                 110 


<210>  483
<211>  111
<212>  PRT
<213>  Homo Sapiens

<400>  483

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu 
            100                 105                 110     


<210>  484
<211>  113
<212>  PRT
<213>  Homo Sapiens

<400>  484

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser 
    


<210>  485
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  485

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala 
        115     


<210>  486
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  486

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala 
        115     


<210>  487
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  487

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu 
        115                 


<210>  488
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  488

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu 
        115                 


<210>  489
<211>  122
<212>  PRT
<213>  Homo Sapiens

<400>  489

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe 
        115                 120         


<210>  490
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  490

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser 
        115                 120                 125             


Leu Ala Gln 
    130     


<210>  491
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  491

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser 
        115                 120                 125             


Leu Ala Gln 
    130     


<210>  492
<211>  141
<212>  PRT
<213>  Homo Sapiens

<400>  492

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser 
        115                 120                 125             


Leu Ala Gln Gly Pro Pro Leu Leu Ala Thr Ser Val Thr 
    130                 135                 140     


<210>  493
<211>  153
<212>  PRT
<213>  Homo Sapiens

<400>  493

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser 
        115                 120                 125             


Leu Ala Gln Gly Pro Pro Leu Leu Ala Thr Ser Val Thr Ser Trp Trp 
    130                 135                 140                 


Ser Pro Gln Asn Ile Ser Leu Pro Ser 
145                 150             


<210>  494
<211>  154
<212>  PRT
<213>  Homo Sapiens

<400>  494

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser 
        115                 120                 125             


Leu Ala Gln Gly Pro Pro Leu Leu Ala Thr Ser Val Thr Ser Trp Trp 
    130                 135                 140                 


Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala 
145                 150                 


<210>  495
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  495

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser 
        115                 120                 125             


Leu Ala Gln Gly Pro Pro Leu Leu Ala Thr Ser Val Thr Ser Trp Trp 
    130                 135                 140                 


Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala Ala Ser Phe Thr Phe Ser 
145                 150                 155                 160 


<210>  496
<211>  162
<212>  PRT
<213>  Homo Sapiens

<400>  496

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser 
        115                 120                 125             


Leu Ala Gln Gly Pro Pro Leu Leu Ala Thr Ser Val Thr Ser Trp Trp 
    130                 135                 140                 


Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala Ala Ser Phe Thr Phe Ser 
145                 150                 155                 160 


Phe His 
        


<210>  497
<211>  167
<212>  PRT
<213>  Homo Sapiens

<400>  497

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser 
        115                 120                 125             


Leu Ala Gln Gly Pro Pro Leu Leu Ala Thr Ser Val Thr Ser Trp Trp 
    130                 135                 140                 


Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala Ala Ser Phe Thr Phe Ser 
145                 150                 155                 160 


Phe His Ser Pro Pro His Thr 
                165         


<210>  498
<211>  167
<212>  PRT
<213>  Homo Sapiens

<400>  498

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser 
        115                 120                 125             


Leu Ala Gln Gly Pro Pro Leu Leu Ala Thr Ser Val Thr Ser Trp Trp 
    130                 135                 140                 


Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala Ala Ser Phe Thr Phe Ser 
145                 150                 155                 160 


Phe His Ser Pro Pro His Thr 
                165         


<210>  499
<211>  199
<212>  PRT
<213>  Homo Sapiens

<400>  499

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser 
        115                 120                 125             


Leu Ala Gln Gly Pro Pro Leu Leu Ala Thr Ser Val Thr Ser Trp Trp 
    130                 135                 140                 


Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala Ala Ser Phe Thr Phe Ser 
145                 150                 155                 160 


Phe His Ser Pro Pro His Thr Ala Ala His Asn Ala Ser Val Asp Met 
                165                 170                 175     


Cys Glu Leu Lys Arg Asp Leu Gln Leu Leu Ser Gln Phe Leu Lys His 
            180                 185                 190         


Pro Gln Lys Ala Ser Arg Arg 
        195                 


<210>  500
<211>  687
<212>  PRT
<213>  Homo Sapiens

<400>  500

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser 
        115                 120                 125             


Leu Ala Gln Gly Pro Pro Leu Leu Ala Thr Ser Val Thr Ser Trp Trp 
    130                 135                 140                 


Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala Ala Ser Phe Thr Phe Ser 
145                 150                 155                 160 


Phe His Ser Pro Pro His Thr Ala Ala His Asn Ala Ser Val Asp Met 
                165                 170                 175     


Cys Glu Leu Lys Arg Asp Leu Gln Leu Leu Ser Gln Phe Leu Lys His 
            180                 185                 190         


Pro Gln Lys Ala Ser Arg Arg Pro Ser Ala Ala Pro Ala Ser Gln Gln 
        195                 200                 205             


Leu Gln Ser Leu Glu Ser Lys Leu Thr Ser Val Arg Phe Met Gly Asp 
    210                 215                 220                 


Met Val Ser Phe Glu Glu Asp Arg Ile Asn Ala Thr Val Trp Lys Leu 
225                 230                 235                 240 


Gln Pro Thr Ala Gly Leu Gln Asp Leu His Ile His Ser Arg Gln Glu 
                245                 250                 255     


Glu Glu Gln Ser Glu Ile Met Glu Tyr Ser Val Leu Leu Pro Arg Thr 
            260                 265                 270         


Leu Phe Gln Arg Thr Lys Gly Arg Ser Gly Glu Ala Glu Lys Arg Leu 
        275                 280                 285             


Leu Leu Val Asp Phe Ser Ser Gln Ala Leu Phe Gln Asp Lys Asn Ser 
    290                 295                 300                 


Ser Gln Val Leu Gly Glu Lys Val Leu Gly Ile Val Val Gln Asn Thr 
305                 310                 315                 320 


Lys Val Ala Asn Leu Thr Glu Pro Val Val Leu Thr Phe Gln His Gln 
                325                 330                 335     


Leu Gln Pro Lys Asn Val Thr Leu Gln Cys Val Phe Trp Val Glu Asp 
            340                 345                 350         


Pro Thr Leu Ser Ser Pro Gly His Trp Ser Ser Ala Gly Cys Glu Thr 
        355                 360                 365             


Val Arg Arg Glu Thr Gln Thr Ser Cys Phe Cys Asn His Leu Thr Tyr 
    370                 375                 380                 


Phe Ala Val Leu Met Val Ser Ser Val Glu Val Asp Ala Val His Lys 
385                 390                 395                 400 


His Tyr Leu Ser Leu Leu Ser Tyr Val Gly Cys Val Val Ser Ala Leu 
                405                 410                 415     


Ala Cys Leu Val Thr Ile Ala Ala Tyr Leu Cys Ser Arg Arg Lys Pro 
            420                 425                 430         


Arg Asp Tyr Thr Ile Lys Val His Met Asn Leu Leu Leu Ala Val Phe 
        435                 440                 445             


Leu Leu Asp Thr Ser Phe Leu Leu Ser Glu Pro Val Ala Leu Thr Gly 
    450                 455                 460                 


Ser Glu Ala Gly Cys Arg Ala Ser Ala Ile Phe Leu His Phe Ser Leu 
465                 470                 475                 480 


Leu Thr Cys Leu Ser Trp Met Gly Leu Glu Gly Tyr Asn Leu Tyr Arg 
                485                 490                 495     


Leu Val Val Glu Val Phe Gly Thr Tyr Val Pro Gly Tyr Leu Leu Lys 
            500                 505                 510         


Leu Ser Ala Met Gly Trp Gly Phe Pro Ile Phe Leu Val Thr Leu Val 
        515                 520                 525             


Ala Leu Val Asp Val Asp Asn Tyr Gly Pro Ile Ile Leu Ala Val His 
    530                 535                 540                 


Arg Thr Pro Glu Gly Val Ile Tyr Pro Ser Met Cys Trp Ile Arg Asp 
545                 550                 555                 560 


Ser Leu Val Ser Tyr Ile Thr Asn Leu Gly Leu Phe Ser Leu Val Phe 
                565                 570                 575     


Leu Phe Asn Met Ala Met Leu Ala Thr Met Val Val Gln Ile Leu Arg 
            580                 585                 590         


Leu Arg Pro His Thr Gln Lys Trp Ser His Val Leu Thr Leu Leu Gly 
        595                 600                 605             


Leu Ser Leu Val Leu Gly Leu Pro Trp Ala Leu Ile Phe Phe Ser Phe 
    610                 615                 620                 


Ala Ser Gly Thr Phe Gln Leu Val Val Leu Tyr Leu Phe Ser Ile Ile 
625                 630                 635                 640 


Thr Ser Phe Gln Gly Phe Leu Ile Phe Ile Trp Tyr Trp Ser Met Arg 
                645                 650                 655     


Leu Gln Ala Arg Gly Gly Pro Ser Pro Leu Lys Ser Asn Ser Asp Ser 
            660                 665                 670         


Ala Arg Leu Pro Ile Ser Ser Gly Ser Thr Ser Ser Ser Arg Ile 
        675                 680                 685         


<210>  501
<211>  687
<212>  PRT
<213>  Homo Sapiens

<400>  501

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser 
        115                 120                 125             


Leu Ala Gln Gly Pro Pro Leu Leu Ala Thr Ser Val Thr Ser Trp Trp 
    130                 135                 140                 


Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala Ala Ser Phe Thr Phe Ser 
145                 150                 155                 160 


Phe His Ser Pro Pro His Thr Ala Ala His Asn Ala Ser Val Asp Met 
                165                 170                 175     


Cys Glu Leu Lys Arg Asp Leu Gln Leu Leu Ser Gln Phe Leu Lys His 
            180                 185                 190         


Pro Gln Lys Ala Ser Arg Arg Pro Ser Ala Ala Pro Ala Ser Gln Gln 
        195                 200                 205             


Leu Gln Ser Leu Glu Ser Lys Leu Thr Ser Val Arg Phe Met Gly Asp 
    210                 215                 220                 


Met Val Ser Phe Glu Glu Asp Arg Ile Asn Ala Thr Val Trp Lys Leu 
225                 230                 235                 240 


Gln Pro Thr Ala Gly Leu Gln Asp Leu His Ile His Ser Arg Gln Glu 
                245                 250                 255     


Glu Glu Gln Ser Glu Ile Met Glu Tyr Ser Val Leu Leu Pro Arg Thr 
            260                 265                 270         


Leu Phe Gln Arg Thr Lys Gly Arg Ser Gly Glu Ala Glu Lys Arg Leu 
        275                 280                 285             


Leu Leu Val Asp Phe Ser Ser Gln Ala Leu Phe Gln Asp Lys Asn Ser 
    290                 295                 300                 


Ser Gln Val Leu Gly Glu Lys Val Leu Gly Ile Val Val Gln Asn Thr 
305                 310                 315                 320 


Lys Val Ala Asn Leu Thr Glu Pro Val Val Leu Thr Phe Gln His Gln 
                325                 330                 335     


Leu Gln Pro Lys Asn Val Thr Leu Gln Cys Val Phe Trp Val Glu Asp 
            340                 345                 350         


Pro Thr Leu Ser Ser Pro Gly His Trp Ser Ser Ala Gly Cys Glu Thr 
        355                 360                 365             


Val Arg Arg Glu Thr Gln Thr Ser Cys Phe Cys Asn His Leu Thr Tyr 
    370                 375                 380                 


Phe Ala Val Leu Met Val Ser Ser Val Glu Val Asp Ala Val His Lys 
385                 390                 395                 400 


His Tyr Leu Ser Leu Leu Ser Tyr Val Gly Cys Val Val Ser Ala Leu 
                405                 410                 415     


Ala Cys Leu Val Thr Ile Ala Ala Tyr Leu Cys Ser Arg Arg Lys Pro 
            420                 425                 430         


Arg Asp Tyr Thr Ile Lys Val His Met Asn Leu Leu Leu Ala Val Phe 
        435                 440                 445             


Leu Leu Asp Thr Ser Phe Leu Leu Ser Glu Pro Val Ala Leu Thr Gly 
    450                 455                 460                 


Ser Glu Ala Gly Cys Arg Ala Ser Ala Ile Phe Leu His Phe Ser Leu 
465                 470                 475                 480 


Leu Thr Cys Leu Ser Trp Met Gly Leu Glu Gly Tyr Asn Leu Tyr Arg 
                485                 490                 495     


Leu Val Val Glu Val Phe Gly Thr Tyr Val Pro Gly Tyr Leu Leu Lys 
            500                 505                 510         


Leu Ser Ala Met Gly Trp Gly Phe Pro Ile Phe Leu Val Thr Leu Val 
        515                 520                 525             


Ala Leu Val Asp Val Asp Asn Tyr Gly Pro Ile Ile Leu Ala Val His 
    530                 535                 540                 


Arg Thr Pro Glu Gly Val Ile Tyr Pro Ser Met Cys Trp Ile Arg Asp 
545                 550                 555                 560 


Ser Leu Val Ser Tyr Ile Thr Asn Leu Gly Leu Phe Ser Leu Val Phe 
                565                 570                 575     


Leu Phe Asn Met Ala Met Leu Ala Thr Met Val Val Gln Ile Leu Arg 
            580                 585                 590         


Leu Arg Pro His Thr Gln Lys Trp Ser His Val Leu Thr Leu Leu Gly 
        595                 600                 605             


Leu Ser Leu Val Leu Gly Leu Pro Trp Ala Leu Ile Phe Phe Ser Phe 
    610                 615                 620                 


Ala Ser Gly Thr Phe Gln Leu Val Val Leu Tyr Leu Phe Ser Ile Ile 
625                 630                 635                 640 


Thr Ser Phe Gln Gly Phe Leu Ile Phe Ile Trp Tyr Trp Ser Met Arg 
                645                 650                 655     


Leu Gln Ala Arg Gly Gly Pro Ser Pro Leu Lys Ser Asn Ser Asp Ser 
            660                 665                 670         


Ala Arg Leu Pro Ile Ser Ser Gly Ser Thr Ser Ser Ser Arg Ile 
        675                 680                 685         


<210>  502
<211>  687
<212>  PRT
<213>  Homo Sapiens

<400>  502

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser 
        115                 120                 125             


Leu Ala Gln Gly Pro Pro Leu Leu Ala Thr Ser Val Thr Ser Trp Trp 
    130                 135                 140                 


Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala Ala Ser Phe Thr Phe Ser 
145                 150                 155                 160 


Phe His Ser Pro Pro His Thr Ala Ala His Asn Ala Ser Val Asp Met 
                165                 170                 175     


Cys Glu Leu Lys Arg Asp Leu Gln Leu Leu Ser Gln Phe Leu Lys His 
            180                 185                 190         


Pro Gln Lys Ala Ser Arg Arg Pro Ser Ala Ala Pro Ala Ser Gln Gln 
        195                 200                 205             


Leu Gln Ser Leu Glu Ser Lys Leu Thr Ser Val Arg Phe Met Gly Asp 
    210                 215                 220                 


Met Val Ser Phe Glu Glu Asp Arg Ile Asn Ala Thr Val Trp Lys Leu 
225                 230                 235                 240 


Gln Pro Thr Ala Gly Leu Gln Asp Leu His Ile His Ser Arg Gln Glu 
                245                 250                 255     


Glu Glu Gln Ser Glu Ile Met Glu Tyr Ser Val Leu Leu Pro Arg Thr 
            260                 265                 270         


Leu Phe Gln Arg Thr Lys Gly Arg Ser Gly Glu Ala Glu Lys Arg Leu 
        275                 280                 285             


Leu Leu Val Asp Phe Ser Ser Gln Ala Leu Phe Gln Asp Lys Asn Ser 
    290                 295                 300                 


Ser Gln Val Leu Gly Glu Lys Val Leu Gly Ile Val Val Gln Asn Thr 
305                 310                 315                 320 


Lys Val Ala Asn Leu Thr Glu Pro Val Val Leu Thr Phe Gln His Gln 
                325                 330                 335     


Leu Gln Pro Lys Asn Val Thr Leu Gln Cys Val Phe Trp Val Glu Asp 
            340                 345                 350         


Pro Thr Leu Ser Ser Pro Gly His Trp Ser Ser Ala Gly Cys Glu Thr 
        355                 360                 365             


Val Arg Arg Glu Thr Gln Thr Ser Cys Phe Cys Asn His Leu Thr Tyr 
    370                 375                 380                 


Phe Ala Val Leu Met Val Ser Ser Val Glu Val Asp Ala Val His Lys 
385                 390                 395                 400 


His Tyr Leu Ser Leu Leu Ser Tyr Val Gly Cys Val Val Ser Ala Leu 
                405                 410                 415     


Ala Cys Leu Val Thr Ile Ala Ala Tyr Leu Cys Ser Arg Arg Lys Pro 
            420                 425                 430         


Arg Asp Tyr Thr Ile Lys Val His Met Asn Leu Leu Leu Ala Val Phe 
        435                 440                 445             


Leu Leu Asp Thr Ser Phe Leu Leu Ser Glu Pro Val Ala Leu Thr Gly 
    450                 455                 460                 


Ser Glu Ala Gly Cys Arg Ala Ser Ala Ile Phe Leu His Phe Ser Leu 
465                 470                 475                 480 


Leu Thr Cys Leu Ser Trp Met Gly Leu Glu Gly Tyr Asn Leu Tyr Arg 
                485                 490                 495     


Leu Val Val Glu Val Phe Gly Thr Tyr Val Pro Gly Tyr Leu Leu Lys 
            500                 505                 510         


Leu Ser Ala Met Gly Trp Gly Phe Pro Ile Phe Leu Val Thr Leu Val 
        515                 520                 525             


Ala Leu Val Asp Val Asp Asn Tyr Gly Pro Ile Ile Leu Ala Val His 
    530                 535                 540                 


Arg Thr Pro Glu Gly Val Ile Tyr Pro Ser Met Cys Trp Ile Arg Asp 
545                 550                 555                 560 


Ser Leu Val Ser Tyr Ile Thr Asn Leu Gly Leu Phe Ser Leu Val Phe 
                565                 570                 575     


Leu Phe Asn Met Ala Met Leu Ala Thr Met Val Val Gln Ile Leu Arg 
            580                 585                 590         


Leu Arg Pro His Thr Gln Lys Trp Ser His Val Leu Thr Leu Leu Gly 
        595                 600                 605             


Leu Ser Leu Val Leu Gly Leu Pro Trp Ala Leu Ile Phe Phe Ser Phe 
    610                 615                 620                 


Ala Ser Gly Thr Phe Gln Leu Val Val Leu Tyr Leu Phe Ser Ile Ile 
625                 630                 635                 640 


Thr Ser Phe Gln Gly Phe Leu Ile Phe Ile Trp Tyr Trp Ser Met Arg 
                645                 650                 655     


Leu Gln Ala Arg Gly Gly Pro Ser Pro Leu Lys Ser Asn Ser Asp Ser 
            660                 665                 670         


Ala Arg Leu Pro Ile Ser Ser Gly Ser Thr Ser Ser Ser Arg Ile 
        675                 680                 685         


<210>  503
<211>  687
<212>  PRT
<213>  Homo Sapiens

<400>  503

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser 
        115                 120                 125             


Leu Ala Gln Gly Pro Pro Leu Leu Ala Thr Ser Val Thr Ser Trp Trp 
    130                 135                 140                 


Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala Ala Ser Phe Thr Phe Ser 
145                 150                 155                 160 


Phe His Ser Pro Pro His Thr Ala Ala His Asn Ala Ser Val Asp Met 
                165                 170                 175     


Cys Glu Leu Lys Arg Asp Leu Gln Leu Leu Ser Gln Phe Leu Lys His 
            180                 185                 190         


Pro Gln Lys Ala Ser Arg Arg Pro Ser Ala Ala Pro Ala Ser Gln Gln 
        195                 200                 205             


Leu Gln Ser Leu Glu Ser Lys Leu Thr Ser Val Arg Phe Met Gly Asp 
    210                 215                 220                 


Met Val Ser Phe Glu Glu Asp Arg Ile Asn Ala Thr Val Trp Lys Leu 
225                 230                 235                 240 


Gln Pro Thr Ala Gly Leu Gln Asp Leu His Ile His Ser Arg Gln Glu 
                245                 250                 255     


Glu Glu Gln Ser Glu Ile Met Glu Tyr Ser Val Leu Leu Pro Arg Thr 
            260                 265                 270         


Leu Phe Gln Arg Thr Lys Gly Arg Ser Gly Glu Ala Glu Lys Arg Leu 
        275                 280                 285             


Leu Leu Val Asp Phe Ser Ser Gln Ala Leu Phe Gln Asp Lys Asn Ser 
    290                 295                 300                 


Ser Gln Val Leu Gly Glu Lys Val Leu Gly Ile Val Val Gln Asn Thr 
305                 310                 315                 320 


Lys Val Ala Asn Leu Thr Glu Pro Val Val Leu Thr Phe Gln His Gln 
                325                 330                 335     


Leu Gln Pro Lys Asn Val Thr Leu Gln Cys Val Phe Trp Val Glu Asp 
            340                 345                 350         


Pro Thr Leu Ser Ser Pro Gly His Trp Ser Ser Ala Gly Cys Glu Thr 
        355                 360                 365             


Val Arg Arg Glu Thr Gln Thr Ser Cys Phe Cys Asn His Leu Thr Tyr 
    370                 375                 380                 


Phe Ala Val Leu Met Val Ser Ser Val Glu Val Asp Ala Val His Lys 
385                 390                 395                 400 


His Tyr Leu Ser Leu Leu Ser Tyr Val Gly Cys Val Val Ser Ala Leu 
                405                 410                 415     


Ala Cys Leu Val Thr Ile Ala Ala Tyr Leu Cys Ser Arg Arg Lys Pro 
            420                 425                 430         


Arg Asp Tyr Thr Ile Lys Val His Met Asn Leu Leu Leu Ala Val Phe 
        435                 440                 445             


Leu Leu Asp Thr Ser Phe Leu Leu Ser Glu Pro Val Ala Leu Thr Gly 
    450                 455                 460                 


Ser Glu Ala Gly Cys Arg Ala Ser Ala Ile Phe Leu His Phe Ser Leu 
465                 470                 475                 480 


Leu Thr Cys Leu Ser Trp Met Gly Leu Glu Gly Tyr Asn Leu Tyr Arg 
                485                 490                 495     


Leu Val Val Glu Val Phe Gly Thr Tyr Val Pro Gly Tyr Leu Leu Lys 
            500                 505                 510         


Leu Ser Ala Met Gly Trp Gly Phe Pro Ile Phe Leu Val Thr Leu Val 
        515                 520                 525             


Ala Leu Val Asp Val Asp Asn Tyr Gly Pro Ile Ile Leu Ala Val His 
    530                 535                 540                 


Arg Thr Pro Glu Gly Val Ile Tyr Pro Ser Met Cys Trp Ile Arg Asp 
545                 550                 555                 560 


Ser Leu Val Ser Tyr Ile Thr Asn Leu Gly Leu Phe Ser Leu Val Phe 
                565                 570                 575     


Leu Phe Asn Met Ala Met Leu Ala Thr Met Val Val Gln Ile Leu Arg 
            580                 585                 590         


Leu Arg Pro His Thr Gln Lys Trp Ser His Val Leu Thr Leu Leu Gly 
        595                 600                 605             


Leu Ser Leu Val Leu Gly Leu Pro Trp Ala Leu Ile Phe Phe Ser Phe 
    610                 615                 620                 


Ala Ser Gly Thr Phe Gln Leu Val Val Leu Tyr Leu Phe Ser Ile Ile 
625                 630                 635                 640 


Thr Ser Phe Gln Gly Phe Leu Ile Phe Ile Trp Tyr Trp Ser Met Arg 
                645                 650                 655     


Leu Gln Ala Arg Gly Gly Pro Ser Pro Leu Lys Ser Asn Ser Asp Ser 
            660                 665                 670         


Ala Arg Leu Pro Ile Ser Ser Gly Ser Thr Ser Ser Ser Arg Ile 
        675                 680                 685         


<210>  504
<211>  693
<212>  PRT
<213>  Homo Sapiens

<400>  504

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser 
        115                 120                 125             


Leu Ala Gln Gly Pro Pro Leu Leu Ala Thr Ser Val Thr Ser Trp Trp 
    130                 135                 140                 


Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala Ala Ser Phe Thr Phe Ser 
145                 150                 155                 160 


Phe His Ser Pro Pro His Thr Ala Ala His Asn Ala Ser Val Asp Met 
                165                 170                 175     


Cys Glu Leu Lys Arg Asp Leu Gln Leu Leu Ser Gln Phe Leu Lys His 
            180                 185                 190         


Pro Gln Lys Ala Ser Arg Arg Pro Ser Ala Ala Pro Ala Ser Gln Gln 
        195                 200                 205             


Leu Gln Ser Leu Glu Ser Lys Leu Thr Ser Val Arg Phe Met Gly Asp 
    210                 215                 220                 


Met Val Ser Phe Glu Glu Asp Arg Ile Asn Ala Thr Val Trp Lys Leu 
225                 230                 235                 240 


Gln Pro Thr Ala Gly Leu Gln Asp Leu His Ile His Ser Arg Gln Glu 
                245                 250                 255     


Glu Glu Gln Ser Glu Ile Met Glu Tyr Ser Val Leu Leu Pro Arg Thr 
            260                 265                 270         


Leu Phe Gln Arg Thr Lys Gly Arg Ser Gly Glu Ala Glu Lys Arg Leu 
        275                 280                 285             


Leu Leu Val Asp Phe Ser Ser Gln Ala Leu Phe Gln Asp Lys Asn Ser 
    290                 295                 300                 


Ser Gln Val Leu Gly Glu Lys Val Leu Gly Ile Val Val Gln Asn Thr 
305                 310                 315                 320 


Lys Val Ala Asn Leu Thr Glu Pro Val Val Leu Thr Phe Gln His Gln 
                325                 330                 335     


Leu Gln Pro Lys Asn Val Thr Leu Gln Cys Val Phe Trp Val Glu Asp 
            340                 345                 350         


Pro Thr Leu Ser Ser Pro Gly His Trp Ser Ser Ala Gly Cys Glu Thr 
        355                 360                 365             


Val Arg Arg Glu Thr Gln Thr Ser Cys Phe Cys Asn His Leu Thr Tyr 
    370                 375                 380                 


Phe Ala Val Leu Met Val Ser Ser Val Glu Val Asp Ala Val His Lys 
385                 390                 395                 400 


His Tyr Leu Ser Leu Leu Ser Tyr Val Gly Cys Val Val Ser Ala Leu 
                405                 410                 415     


Ala Cys Leu Val Thr Ile Ala Ala Tyr Leu Cys Ser Arg Val Pro Leu 
            420                 425                 430         


Pro Cys Arg Arg Lys Pro Arg Asp Tyr Thr Ile Lys Val His Met Asn 
        435                 440                 445             


Leu Leu Leu Ala Val Phe Leu Leu Asp Thr Ser Phe Leu Leu Ser Glu 
    450                 455                 460                 


Pro Val Ala Leu Thr Gly Ser Glu Ala Gly Cys Arg Ala Ser Ala Ile 
465                 470                 475                 480 


Phe Leu His Phe Ser Leu Leu Thr Cys Leu Ser Trp Met Gly Leu Glu 
                485                 490                 495     


Gly Tyr Asn Leu Tyr Arg Leu Val Val Glu Val Phe Gly Thr Tyr Val 
            500                 505                 510         


Pro Gly Tyr Leu Leu Lys Leu Ser Ala Met Gly Trp Gly Phe Pro Ile 
        515                 520                 525             


Phe Leu Val Thr Leu Val Ala Leu Val Asp Val Asp Asn Tyr Gly Pro 
    530                 535                 540                 


Ile Ile Leu Ala Val His Arg Thr Pro Glu Gly Val Ile Tyr Pro Ser 
545                 550                 555                 560 


Met Cys Trp Ile Arg Asp Ser Leu Val Ser Tyr Ile Thr Asn Leu Gly 
                565                 570                 575     


Leu Phe Ser Leu Val Phe Leu Phe Asn Met Ala Met Leu Ala Thr Met 
            580                 585                 590         


Val Val Gln Ile Leu Arg Leu Arg Pro His Thr Gln Lys Trp Ser His 
        595                 600                 605             


Val Leu Thr Leu Leu Gly Leu Ser Leu Val Leu Gly Leu Pro Trp Ala 
    610                 615                 620                 


Leu Ile Phe Phe Ser Phe Ala Ser Gly Thr Phe Gln Leu Val Val Leu 
625                 630                 635                 640 


Tyr Leu Phe Ser Ile Ile Thr Ser Phe Gln Gly Phe Leu Ile Phe Ile 
                645                 650                 655     


Trp Tyr Trp Ser Met Arg Leu Gln Ala Arg Gly Gly Pro Ser Pro Leu 
            660                 665                 670         


Lys Ser Asn Ser Asp Ser Ala Arg Leu Pro Ile Ser Ser Gly Ser Thr 
        675                 680                 685             


Ser Ser Ser Arg Ile 
    690             


<210>  505
<211>  693
<212>  PRT
<213>  Homo Sapiens

<400>  505

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser 
        115                 120                 125             


Leu Ala Gln Gly Pro Pro Leu Leu Ala Thr Ser Val Thr Ser Trp Trp 
    130                 135                 140                 


Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala Ala Ser Phe Thr Phe Ser 
145                 150                 155                 160 


Phe His Ser Pro Pro His Thr Ala Ala His Asn Ala Ser Val Asp Met 
                165                 170                 175     


Cys Glu Leu Lys Arg Asp Leu Gln Leu Leu Ser Gln Phe Leu Lys His 
            180                 185                 190         


Pro Gln Lys Ala Ser Arg Arg Pro Ser Ala Ala Pro Ala Ser Gln Gln 
        195                 200                 205             


Leu Gln Ser Leu Glu Ser Lys Leu Thr Ser Val Arg Phe Met Gly Asp 
    210                 215                 220                 


Met Val Ser Phe Glu Glu Asp Arg Ile Asn Ala Thr Val Trp Lys Leu 
225                 230                 235                 240 


Gln Pro Thr Ala Gly Leu Gln Asp Leu His Ile His Ser Arg Gln Glu 
                245                 250                 255     


Glu Glu Gln Ser Glu Ile Met Glu Tyr Ser Val Leu Leu Pro Arg Thr 
            260                 265                 270         


Leu Phe Gln Arg Thr Lys Gly Arg Ser Gly Glu Ala Glu Lys Arg Leu 
        275                 280                 285             


Leu Leu Val Asp Phe Ser Ser Gln Ala Leu Phe Gln Asp Lys Asn Ser 
    290                 295                 300                 


Ser Gln Val Leu Gly Glu Lys Val Leu Gly Ile Val Val Gln Asn Thr 
305                 310                 315                 320 


Lys Val Ala Asn Leu Thr Glu Pro Val Val Leu Thr Phe Gln His Gln 
                325                 330                 335     


Leu Gln Pro Lys Asn Val Thr Leu Gln Cys Val Phe Trp Val Glu Asp 
            340                 345                 350         


Pro Thr Leu Ser Ser Pro Gly His Trp Ser Ser Ala Gly Cys Glu Thr 
        355                 360                 365             


Val Arg Arg Glu Thr Gln Thr Ser Cys Phe Cys Asn His Leu Thr Tyr 
    370                 375                 380                 


Phe Ala Val Leu Met Val Ser Ser Val Glu Val Asp Ala Val His Lys 
385                 390                 395                 400 


His Tyr Leu Ser Leu Leu Ser Tyr Val Gly Cys Val Val Ser Ala Leu 
                405                 410                 415     


Ala Cys Leu Val Thr Ile Ala Ala Tyr Leu Cys Ser Arg Val Pro Leu 
            420                 425                 430         


Pro Cys Arg Arg Lys Pro Arg Asp Tyr Thr Ile Lys Val His Met Asn 
        435                 440                 445             


Leu Leu Leu Ala Val Phe Leu Leu Asp Thr Ser Phe Leu Leu Ser Glu 
    450                 455                 460                 


Pro Val Ala Leu Thr Gly Ser Glu Ala Gly Cys Arg Ala Ser Ala Ile 
465                 470                 475                 480 


Phe Leu His Phe Ser Leu Leu Thr Cys Leu Ser Trp Met Gly Leu Glu 
                485                 490                 495     


Gly Tyr Asn Leu Tyr Arg Leu Val Val Glu Val Phe Gly Thr Tyr Val 
            500                 505                 510         


Pro Gly Tyr Leu Leu Lys Leu Ser Ala Met Gly Trp Gly Phe Pro Ile 
        515                 520                 525             


Phe Leu Val Thr Leu Val Ala Leu Val Asp Val Asp Asn Tyr Gly Pro 
    530                 535                 540                 


Ile Ile Leu Ala Val His Arg Thr Pro Glu Gly Val Ile Tyr Pro Ser 
545                 550                 555                 560 


Met Cys Trp Ile Arg Asp Ser Leu Val Ser Tyr Ile Thr Asn Leu Gly 
                565                 570                 575     


Leu Phe Ser Leu Val Phe Leu Phe Asn Met Ala Met Leu Ala Thr Met 
            580                 585                 590         


Val Val Gln Ile Leu Arg Leu Arg Pro His Thr Gln Lys Trp Ser His 
        595                 600                 605             


Val Leu Thr Leu Leu Gly Leu Ser Leu Val Leu Gly Leu Pro Trp Ala 
    610                 615                 620                 


Leu Ile Phe Phe Ser Phe Ala Ser Gly Thr Phe Gln Leu Val Val Leu 
625                 630                 635                 640 


Tyr Leu Phe Ser Ile Ile Thr Ser Phe Gln Gly Phe Leu Ile Phe Ile 
                645                 650                 655     


Trp Tyr Trp Ser Met Arg Leu Gln Ala Arg Gly Gly Pro Ser Pro Leu 
            660                 665                 670         


Lys Ser Asn Ser Asp Ser Ala Arg Leu Pro Ile Ser Ser Gly Ser Thr 
        675                 680                 685             


Ser Ser Ser Arg Ile 
    690             


<210>  506
<211>  687
<212>  PRT
<213>  Homo Sapiens

<400>  506

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser 
        115                 120                 125             


Leu Ala Gln Gly Pro Pro Leu Leu Ala Thr Ser Val Thr Ser Trp Trp 
    130                 135                 140                 


Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala Ala Ser Phe Thr Phe Ser 
145                 150                 155                 160 


Phe His Ser Pro Pro His Thr Ala Ala His Asn Ala Ser Val Asp Met 
                165                 170                 175     


Cys Glu Leu Lys Arg Asp Leu Gln Leu Leu Ser Gln Phe Leu Lys His 
            180                 185                 190         


Pro Gln Lys Ala Ser Arg Arg Pro Ser Ala Ala Pro Ala Ser Gln Gln 
        195                 200                 205             


Leu Gln Ser Leu Glu Ser Lys Leu Thr Ser Val Arg Phe Met Gly Asp 
    210                 215                 220                 


Met Val Ser Phe Glu Glu Asp Arg Ile Asn Ala Thr Val Trp Lys Leu 
225                 230                 235                 240 


Gln Pro Thr Ala Gly Leu Gln Asp Leu His Ile His Ser Arg Gln Glu 
                245                 250                 255     


Glu Glu Gln Ser Glu Ile Met Glu Tyr Ser Val Leu Leu Pro Arg Thr 
            260                 265                 270         


Leu Phe Gln Arg Thr Lys Gly Arg Ser Gly Glu Ala Glu Lys Arg Leu 
        275                 280                 285             


Leu Leu Val Asp Phe Ser Ser Gln Ala Leu Phe Gln Asp Lys Asn Ser 
    290                 295                 300                 


Ser Gln Val Leu Gly Glu Lys Val Leu Gly Ile Val Val Gln Asn Thr 
305                 310                 315                 320 


Lys Val Ala Asn Leu Thr Glu Pro Val Val Leu Thr Phe Gln His Gln 
                325                 330                 335     


Leu Gln Pro Lys Asn Val Thr Leu Gln Cys Val Phe Trp Val Glu Asp 
            340                 345                 350         


Pro Thr Leu Ser Ser Pro Gly His Trp Ser Ser Ala Gly Cys Glu Thr 
        355                 360                 365             


Val Arg Arg Glu Thr Gln Thr Ser Cys Phe Cys Asn His Leu Thr Tyr 
    370                 375                 380                 


Phe Ala Val Leu Met Val Ser Ser Val Glu Val Asp Ala Val His Lys 
385                 390                 395                 400 


His Tyr Leu Ser Leu Leu Ser Tyr Val Gly Cys Val Val Ser Ala Leu 
                405                 410                 415     


Ala Cys Leu Val Thr Ile Ala Ala Tyr Leu Cys Ser Arg Arg Lys Pro 
            420                 425                 430         


Arg Asp Tyr Thr Ile Lys Val His Met Asn Leu Leu Leu Ala Val Phe 
        435                 440                 445             


Leu Leu Asp Thr Ser Phe Leu Leu Ser Glu Pro Val Ala Leu Thr Gly 
    450                 455                 460                 


Ser Glu Ala Gly Cys Arg Ala Ser Ala Ile Phe Leu His Phe Ser Leu 
465                 470                 475                 480 


Leu Thr Cys Leu Ser Trp Met Gly Leu Glu Gly Tyr Asn Leu Tyr Arg 
                485                 490                 495     


Leu Val Val Glu Val Phe Gly Thr Tyr Val Pro Gly Tyr Leu Leu Lys 
            500                 505                 510         


Leu Ser Ala Met Gly Trp Gly Phe Pro Ile Phe Leu Val Thr Leu Val 
        515                 520                 525             


Ala Leu Val Asp Val Asp Asn Tyr Gly Pro Ile Ile Leu Ala Val His 
    530                 535                 540                 


Arg Thr Pro Glu Gly Val Ile Tyr Pro Ser Met Cys Trp Ile Arg Asp 
545                 550                 555                 560 


Ser Leu Val Ser Tyr Ile Thr Asn Leu Gly Leu Phe Ser Leu Val Phe 
                565                 570                 575     


Leu Phe Asn Met Ala Met Leu Ala Thr Met Val Val Gln Ile Leu Arg 
            580                 585                 590         


Leu Arg Pro His Thr Gln Lys Trp Ser His Val Leu Thr Leu Leu Gly 
        595                 600                 605             


Leu Ser Leu Val Leu Gly Leu Pro Trp Ala Leu Ile Phe Phe Ser Phe 
    610                 615                 620                 


Ala Ser Gly Thr Phe Gln Leu Val Val Leu Tyr Leu Phe Ser Ile Ile 
625                 630                 635                 640 


Thr Ser Phe Gln Gly Phe Leu Ile Phe Ile Trp Tyr Trp Ser Met Arg 
                645                 650                 655     


Leu Gln Ala Arg Gly Gly Pro Ser Pro Leu Lys Ser Asn Ser Asp Ser 
            660                 665                 670         


Ala Arg Leu Pro Ile Ser Ser Gly Ser Thr Ser Ser Ser Arg Ile 
        675                 680                 685         


<210>  507
<211>  256
<212>  PRT
<213>  Homo Sapiens

<400>  507

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser 
        115                 120                 125             


Leu Ala Gln Gly Pro Pro Leu Leu Ala Thr Ser Val Thr Ser Trp Trp 
    130                 135                 140                 


Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala Ala Ser Phe Thr Phe Ser 
145                 150                 155                 160 


Phe His Ser Pro Pro His Thr Ala Ala His Asn Ala Ser Val Asp Met 
                165                 170                 175     


Cys Glu Leu Lys Arg Asp Leu Gln Leu Leu Ser Gln Phe Leu Lys His 
            180                 185                 190         


Pro Gln Lys Ala Ser Arg Arg Pro Ser Ala Ala Pro Ala Ser Gln Gln 
        195                 200                 205             


Leu Gln Ser Leu Glu Ser Lys Leu Thr Ser Val Arg Phe Met Gly Asp 
    210                 215                 220                 


Met Val Ser Phe Glu Glu Asp Arg Ile Asn Ala Thr Val Trp Lys Leu 
225                 230                 235                 240 


Gln Pro Thr Ala Gly Leu Gln Asp Leu His Ile His Ser Arg Gln Glu 
                245                 250                 255     


<210>  508
<211>  78
<212>  PRT
<213>  Homo Sapiens

<400>  508

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Arg Cys Pro Arg Gln Gly Pro Gln Gly Arg 
            20                  25                  30          


Leu Ser Leu Leu Gln Pro Ala Glu Pro Asp Thr Gln Glu Gln Pro Pro 
        35                  40                  45              


Leu Gln Thr His Thr Arg Pro Ala His Leu His Arg Glu Leu Arg Arg 
    50                  55                  60                  


Gly Pro His Ser Pro Cys Pro Phe Pro Cys Ser Pro Pro Cys 
65                  70                  75              


<210>  509
<211>  81
<212>  PRT
<213>  Homo Sapiens

<400>  509

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Arg Cys Pro Arg Gln Gly Pro Gln Gly Arg 
            20                  25                  30          


Leu Ser Leu Leu Gln Pro Ala Glu Pro Asp Thr Gln Glu Gln Pro Pro 
        35                  40                  45              


Leu Gln Thr His Thr Arg Pro Ala His Leu His Arg Glu Leu Arg Arg 
    50                  55                  60                  


Gly Pro His Ser Pro Cys Pro Phe Pro Cys Ser Pro Pro Cys Phe Pro 
65                  70                  75                  80  


Ile 
    


<210>  510
<211>  97
<212>  PRT
<213>  Homo Sapiens

<400>  510

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ser Gly Thr Arg His Thr Gly Ala Ala Ser 
            20                  25                  30          


Thr Thr Asn Pro His Gln Thr Cys Ala Ser Pro Ser Arg Thr Pro Lys 
        35                  40                  45              


Arg Pro Ser Gln Ser Met Pro Leu Ser Leu Gln Pro Thr Leu Leu Pro 
    50                  55                  60                  


Asp Pro Ser Leu Thr Pro Gly Ala Ser Thr Thr Ser Ala Ser Thr Gly 
65                  70                  75                  80  


Thr Asp Met Leu Gly Asp Tyr Ile Phe Ser Met Ala Ser Val Thr Ser 
                85                  90                  95      


Cys 
    


<210>  511
<211>  97
<212>  PRT
<213>  Homo Sapiens

<400>  511

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ser Gly Thr Arg His Thr Gly Ala Ala Ser 
            20                  25                  30          


Thr Thr Asn Pro His Gln Thr Cys Ala Ser Pro Ser Arg Thr Pro Lys 
        35                  40                  45              


Arg Pro Ser Gln Ser Met Pro Leu Ser Leu Gln Pro Thr Leu Leu Pro 
    50                  55                  60                  


Asp Pro Ser Leu Thr Pro Gly Ala Ser Thr Thr Ser Ala Ser Thr Gly 
65                  70                  75                  80  


Thr Asp Met Leu Gly Asp Tyr Ile Phe Ser Met Ala Ser Val Thr Ser 
                85                  90                  95      


Cys 
    


<210>  512
<211>  187
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  512

Xaa Ser Val Asp Met Cys Glu Leu Lys Arg Asp Leu Gln Leu Leu Ser 
1               5                   10                  15      


Gln Phe Leu Lys His Pro Gln Lys Ala Ser Arg Arg Pro Ser Ala Ala 
            20                  25                  30          


Pro Ala Ser Gln Gln Leu Gln Ser Leu Glu Ser Lys Leu Thr Ser Val 
        35                  40                  45              


Arg Phe Met Gly Asp Met Val Ser Phe Glu Glu Asp Arg Ile Asn Ala 
    50                  55                  60                  


Thr Val Trp Lys Leu Gln Pro Thr Ala Gly Leu Gln Asp Leu His Ile 
65                  70                  75                  80  


His Ser Arg Gln Glu Glu Glu Gln Ser Glu Ile Met Glu Tyr Ser Val 
                85                  90                  95      


Leu Leu Pro Arg Thr Leu Phe Gln Arg Thr Lys Gly Arg Ser Gly Glu 
            100                 105                 110         


Ala Glu Lys Arg Leu Leu Leu Val Asp Phe Ser Ser Gln Ala Leu Phe 
        115                 120                 125             


Gln Asp Lys Asn Ser Ser Gln Val Leu Gly Glu Lys Val Phe Gly Thr 
    130                 135                 140                 


Tyr Val Pro Gly Tyr Leu Leu Lys Leu Ser Ala Met Gly Trp Gly Phe 
145                 150                 155                 160 


Pro Ile Phe Leu Val Thr Leu Val Ala Leu Val Asp Val Asp Asn Tyr 
                165                 170                 175     


Gly Pro Ile Ile Leu Ala Val His Arg Thr Pro 
            180                 185         


<210>  513
<211>  528
<212>  PRT
<213>  Homo Sapiens

<400>  513

Met Asp His Cys Gly Ala Leu Phe Leu Cys Leu Cys Leu Leu Thr Leu 
1               5                   10                  15      


Gln Asn Ala Thr Thr Glu Thr Trp Glu Glu Leu Leu Ser Tyr Met Glu 
            20                  25                  30          


Asn Met Gln Val Ser Arg Gly Arg Ser Ser Val Phe Ser Ser Arg Gln 
        35                  40                  45              


Leu His Gln Leu Glu Gln Met Leu Leu Asn Thr Ser Phe Pro Gly Tyr 
    50                  55                  60                  


Asn Leu Thr Leu Gln Thr Pro Thr Ile Gln Ser Leu Ala Phe Lys Leu 
65                  70                  75                  80  


Ser Cys Asp Phe Ser Gly Leu Ser Leu Thr Ser Ala Thr Leu Lys Arg 
                85                  90                  95      


Val Pro Gln Ala Gly Gly Gln His Ala Arg Gly Gln His Ala Met Gln 
            100                 105                 110         


Phe Pro Ala Glu Leu Thr Arg Asp Ala Cys Lys Thr Arg Pro Arg Glu 
        115                 120                 125             


Leu Arg Leu Ile Cys Ile Tyr Phe Ser Asn Thr His Phe Phe Lys Asp 
    130                 135                 140                 


Glu Asn Asn Ser Ser Leu Leu Asn Asn Tyr Val Leu Gly Ala Gln Leu 
145                 150                 155                 160 


Ser His Gly His Val Asn Asn Leu Arg Asp Pro Val Asn Ile Ser Phe 
                165                 170                 175     


Trp His Asn Gln Ser Leu Glu Gly Tyr Thr Leu Thr Cys Val Phe Trp 
            180                 185                 190         


Lys Glu Gly Ala Arg Lys Gln Pro Trp Gly Gly Trp Ser Pro Glu Gly 
        195                 200                 205             


Cys Arg Thr Glu Gln Pro Ser His Ser Gln Val Leu Cys Arg Cys Asn 
    210                 215                 220                 


His Leu Thr Tyr Phe Ala Val Leu Met Gln Leu Ser Pro Ala Leu Val 
225                 230                 235                 240 


Pro Ala Glu Leu Leu Ala Pro Leu Thr Tyr Ile Ser Leu Val Gly Cys 
                245                 250                 255     


Ser Ile Ser Ile Val Ala Ser Leu Ile Thr Val Leu Leu His Phe His 
            260                 265                 270         


Phe Arg Lys Gln Ser Asp Ser Leu Thr Arg Ile His Met Asn Leu His 
        275                 280                 285             


Ala Ser Val Leu Leu Leu Asn Ile Ala Phe Leu Leu Ser Pro Ala Phe 
    290                 295                 300                 


Ala Met Ser Pro Val Pro Gly Ser Ala Cys Thr Ala Leu Ala Ala Ala 
305                 310                 315                 320 


Leu His Tyr Ala Leu Leu Ser Cys Leu Thr Trp Met Ala Ile Glu Gly 
                325                 330                 335     


Phe Asn Leu Tyr Leu Leu Leu Gly Arg Val Tyr Asn Ile Tyr Ile Arg 
            340                 345                 350         


Arg Tyr Val Phe Lys Leu Gly Val Leu Gly Trp Gly Ala Pro Ala Leu 
        355                 360                 365             


Leu Val Leu Leu Ser Leu Ser Val Lys Ser Ser Val Tyr Gly Pro Cys 
    370                 375                 380                 


Thr Ile Pro Val Phe Asp Ser Trp Glu Asn Gly Thr Gly Phe Gln Asn 
385                 390                 395                 400 


Met Ser Ile Cys Trp Val Arg Ser Pro Val Val His Ser Val Leu Val 
                405                 410                 415     


Met Gly Tyr Gly Gly Leu Thr Ser Leu Phe Asn Leu Val Val Leu Ala 
            420                 425                 430         


Trp Ala Leu Trp Thr Leu Arg Arg Leu Arg Glu Arg Ala Asp Ala Pro 
        435                 440                 445             


Ser Val Arg Ala Cys His Asp Thr Val Thr Val Leu Gly Leu Thr Val 
    450                 455                 460                 


Leu Leu Gly Thr Thr Trp Ala Leu Ala Phe Phe Ser Phe Gly Val Phe 
465                 470                 475                 480 


Leu Leu Pro Gln Leu Phe Leu Phe Thr Ile Leu Asn Ser Leu Tyr Gly 
                485                 490                 495     


Phe Phe Leu Phe Leu Trp Phe Cys Ser Gln Arg Cys Arg Ser Glu Ala 
            500                 505                 510         


Glu Ala Lys Ala Gln Ile Glu Ala Phe Ser Ser Ser Gln Thr Thr Gln 
        515                 520                 525             


<210>  514
<211>  528
<212>  PRT
<213>  Homo Sapiens

<400>  514

Met Asp His Cys Gly Ala Leu Phe Leu Cys Leu Cys Leu Leu Thr Leu 
1               5                   10                  15      


Gln Asn Ala Thr Thr Glu Thr Trp Glu Glu Leu Leu Ser Tyr Met Glu 
            20                  25                  30          


Asn Met Gln Val Ser Arg Gly Arg Ser Ser Val Phe Ser Ser Arg Gln 
        35                  40                  45              


Leu His Gln Leu Glu Gln Met Leu Leu Asn Thr Ser Phe Pro Gly Tyr 
    50                  55                  60                  


Asn Leu Thr Leu Gln Thr Pro Thr Ile Gln Ser Leu Ala Phe Lys Leu 
65                  70                  75                  80  


Ser Cys Asp Phe Ser Gly Leu Ser Leu Thr Ser Ala Thr Leu Lys Arg 
                85                  90                  95      


Val Pro Gln Ala Gly Gly Gln His Ala Arg Gly Gln His Ala Met Gln 
            100                 105                 110         


Phe Pro Ala Glu Leu Thr Arg Asp Ala Cys Lys Thr Arg Pro Arg Glu 
        115                 120                 125             


Leu Arg Leu Ile Cys Ile Tyr Phe Ser Asn Thr His Phe Phe Lys Asp 
    130                 135                 140                 


Glu Asn Asn Ser Ser Leu Leu Asn Asn Tyr Val Leu Gly Ala Gln Leu 
145                 150                 155                 160 


Ser His Gly His Val Asn Asn Leu Arg Asp Pro Val Asn Ile Ser Phe 
                165                 170                 175     


Trp His Asn Gln Ser Leu Glu Gly Tyr Thr Leu Thr Cys Val Phe Trp 
            180                 185                 190         


Lys Glu Gly Ala Arg Lys Gln Pro Trp Gly Gly Trp Ser Pro Glu Gly 
        195                 200                 205             


Cys Arg Thr Glu Gln Pro Ser His Ser Gln Val Leu Cys Arg Cys Asn 
    210                 215                 220                 


His Leu Thr Tyr Phe Ala Val Leu Met Gln Leu Ser Pro Ala Leu Val 
225                 230                 235                 240 


Pro Ala Glu Leu Leu Ala Pro Leu Thr Tyr Ile Ser Leu Val Gly Cys 
                245                 250                 255     


Ser Ile Ser Ile Val Ala Ser Leu Ile Thr Val Leu Leu His Phe His 
            260                 265                 270         


Phe Arg Lys Gln Ser Asp Ser Leu Thr Arg Ile His Met Asn Leu His 
        275                 280                 285             


Ala Ser Val Leu Leu Leu Asn Ile Ala Phe Leu Leu Ser Pro Ala Phe 
    290                 295                 300                 


Ala Met Ser Pro Val Pro Gly Ser Ala Cys Thr Ala Leu Ala Ala Ala 
305                 310                 315                 320 


Leu His Tyr Ala Leu Leu Ser Cys Leu Thr Trp Met Ala Ile Glu Gly 
                325                 330                 335     


Phe Asn Leu Tyr Leu Leu Leu Gly Arg Val Tyr Asn Ile Tyr Ile Arg 
            340                 345                 350         


Arg Tyr Val Phe Lys Leu Gly Val Leu Gly Trp Gly Ala Pro Ala Leu 
        355                 360                 365             


Leu Val Leu Leu Ser Leu Ser Val Lys Ser Ser Val Tyr Gly Pro Cys 
    370                 375                 380                 


Thr Ile Pro Val Phe Asp Ser Trp Glu Asn Gly Thr Gly Phe Gln Asn 
385                 390                 395                 400 


Met Ser Ile Cys Trp Val Arg Ser Pro Val Val His Ser Val Leu Val 
                405                 410                 415     


Met Gly Tyr Gly Gly Leu Thr Ser Leu Phe Asn Leu Val Val Leu Ala 
            420                 425                 430         


Trp Ala Leu Trp Thr Leu Arg Arg Leu Arg Glu Arg Ala Asp Ala Pro 
        435                 440                 445             


Ser Val Arg Ala Cys His Asp Thr Val Thr Val Leu Gly Leu Thr Val 
    450                 455                 460                 


Leu Leu Gly Thr Thr Trp Ala Leu Ala Phe Phe Ser Phe Gly Val Phe 
465                 470                 475                 480 


Leu Leu Pro Gln Leu Phe Leu Phe Thr Ile Leu Asn Ser Leu Tyr Gly 
                485                 490                 495     


Phe Phe Leu Phe Leu Trp Phe Cys Ser Gln Arg Cys Arg Ser Glu Ala 
            500                 505                 510         


Glu Ala Lys Ala Gln Ile Glu Ala Phe Ser Ser Ser Gln Thr Thr Gln 
        515                 520                 525             


<210>  515
<211>  221
<212>  PRT
<213>  Homo Sapiens

<400>  515

Met Asp His Cys Gly Ala Leu Phe Leu Cys Leu Cys Leu Leu Thr Leu 
1               5                   10                  15      


Gln Asn Ala Thr Thr Glu Thr Trp Glu Glu Leu Leu Ser Tyr Met Glu 
            20                  25                  30          


Asn Met Gln Val Ser Arg Gly Arg Ser Ser Val Phe Ser Ser Arg Gln 
        35                  40                  45              


Leu His Gln Leu Glu Gln Met Leu Leu Asn Thr Ser Phe Pro Gly Tyr 
    50                  55                  60                  


Asn Leu Thr Leu Gln Thr Pro Thr Ile Gln Ser Leu Ala Phe Lys Leu 
65                  70                  75                  80  


Ser Cys Asp Phe Ser Gly Leu Ser Leu Thr Ser Ala Thr Leu Lys Arg 
                85                  90                  95      


Val Pro Gln Ala Gly Gly Gln His Ala Arg Gly Gln His Ala Met Gln 
            100                 105                 110         


Phe Pro Ala Glu Leu Thr Arg Asp Ala Cys Lys Thr Arg Pro Arg Glu 
        115                 120                 125             


Leu Arg Leu Ile Cys Ile Tyr Phe Ser Asn Thr His Phe Phe Lys Asp 
    130                 135                 140                 


Glu Asn Asn Ser Ser Leu Leu Asn Asn Tyr Val Leu Gly Ala Gln Leu 
145                 150                 155                 160 


Ser His Gly His Val Asn Asn Leu Arg Asp Pro Val Asn Ile Ser Phe 
                165                 170                 175     


Trp His Asn Gln Ser Leu Val Leu Leu Gly Ala Pro Pro Phe Pro Leu 
            180                 185                 190         


His Pro Cys Pro Ser Val Thr Leu Leu Leu Asn Thr Gly Leu Thr Arg 
        195                 200                 205             


Pro Lys Pro Val Glu Pro Ser Trp Lys Ser Ile Thr Leu 
    210                 215                 220     


<210>  516
<211>  141
<212>  PRT
<213>  Homo Sapiens

<400>  516

Met Phe Arg Ser Asp Arg Met Trp Ser Cys His Trp Lys Trp Lys Pro 
1               5                   10                  15      


Ser Pro Leu Leu Phe Leu Phe Ala Leu Tyr Ile Met Cys Val Pro His 
            20                  25                  30          


Ser Ala Val Trp Gly Cys Ala Asn Cys Arg Val Val Leu Ser Asn Pro 
        35                  40                  45              


Ser Gly Thr Phe Thr Ser Pro Cys Tyr Pro Asn Asp Tyr Pro Asn Ser 
    50                  55                  60                  


Gln Ala Cys Met Trp Thr Leu Arg Ala Pro Thr Gly Tyr Ile Ile Gln 
65                  70                  75                  80  


Ile Thr Phe Asn Asp Phe Asp Ile Glu Glu Ala Pro Asn Cys Ile Tyr 
                85                  90                  95      


Asp Ser Leu Ser Leu Asp Asn Gly Glu Ser Gln Thr Lys Phe Cys Gly 
            100                 105                 110         


Ala Thr Ala Lys Gly Leu Ser Phe Asn Ser Ser Ala Asn Glu Met His 
        115                 120                 125             


Val Ser Phe Ser Ser Asp Phe Ser Ile Gln Lys Lys Gly 
    130                 135                 140     


<210>  517
<211>  241
<212>  PRT
<213>  Homo Sapiens

<400>  517

Met Phe Arg Ser Asp Arg Met Trp Ser Cys His Trp Lys Trp Lys Pro 
1               5                   10                  15      


Ser Pro Leu Leu Phe Leu Phe Ala Leu Tyr Ile Met Cys Val Pro His 
            20                  25                  30          


Ser Val Trp Gly Cys Ala Asn Cys Arg Val Val Leu Ser Asn Pro Ser 
        35                  40                  45              


Gly Thr Phe Thr Ser Pro Cys Tyr Pro Asn Asp Tyr Pro Asn Ser Gln 
    50                  55                  60                  


Ala Cys Met Trp Thr Leu Arg Ala Pro Thr Gly Tyr Ile Ile Gln Ile 
65                  70                  75                  80  


Thr Phe Asn Asp Phe Asp Ile Glu Glu Ala Pro Asn Cys Ile Tyr Asp 
                85                  90                  95      


Ser Leu Ser Leu Asp Asn Gly Glu Ser Gln Thr Lys Phe Cys Gly Ala 
            100                 105                 110         


Thr Ala Lys Gly Leu Ser Phe Asn Ser Ser Ala Asn Glu Met His Val 
        115                 120                 125             


Ser Phe Ser Ser Asp Phe Ser Ile Gln Lys Lys Gly Phe Asn Ala Ser 
    130                 135                 140                 


Tyr Ile Arg Val Ala Val Ser Leu Arg Asn Gln Lys Val Ile Leu Pro 
145                 150                 155                 160 


Gln Thr Ser Asp Ala Tyr Gln Val Ser Val Ala Lys Ser Ile Ser Ile 
                165                 170                 175     


Pro Glu Leu Ser Ala Phe Thr Leu Cys Phe Glu Ala Thr Lys Val Gly 
            180                 185                 190         


His Glu Asp Ser Asp Trp Thr Ala Phe Ser Tyr Ser Asn Ala Ser Phe 
        195                 200                 205             


Thr Gln Leu Leu Ser Phe Gly Lys Ala Lys Ser Gly Tyr Phe Leu Ser 
    210                 215                 220                 


Ile Ser Asp Ser Lys Cys Leu Leu Asn Asn Ala Leu Pro Val Lys Glu 
225                 230                 235                 240 


Lys 
    


<210>  518
<211>  1221
<212>  PRT
<213>  Homo Sapiens

<400>  518

Met Met Phe Arg Ser Asp Arg Met Trp Ser Cys His Trp Lys Trp Lys 
1               5                   10                  15      


Pro Ser Pro Leu Leu Phe Leu Phe Ala Leu Tyr Ile Met Cys Val Pro 
            20                  25                  30          


His Ser Val Trp Gly Cys Ala Asn Cys Arg Val Val Leu Ser Asn Pro 
        35                  40                  45              


Ser Gly Thr Phe Thr Ser Pro Cys Tyr Pro Asn Asp Tyr Pro Asn Ser 
    50                  55                  60                  


Gln Ala Cys Met Trp Thr Leu Arg Ala Pro Thr Gly Tyr Ile Ile Gln 
65                  70                  75                  80  


Ile Thr Phe Asn Asp Phe Asp Ile Glu Glu Ala Pro Asn Cys Ile Tyr 
                85                  90                  95      


Asp Ser Leu Ser Leu Asp Asn Gly Glu Ser Gln Thr Lys Phe Cys Gly 
            100                 105                 110         


Ala Thr Ala Lys Gly Leu Ser Phe Asn Ser Ser Ala Asn Glu Met His 
        115                 120                 125             


Val Ser Phe Ser Ser Asp Phe Ser Ile Gln Lys Lys Gly Phe Asn Ala 
    130                 135                 140                 


Ser Tyr Ile Arg Val Ala Val Ser Leu Arg Asn Gln Lys Val Ile Leu 
145                 150                 155                 160 


Pro Gln Thr Ser Asp Ala Tyr Gln Val Ser Val Ala Lys Ser Ile Ser 
                165                 170                 175     


Ile Pro Glu Leu Ser Ala Phe Thr Leu Cys Phe Glu Ala Thr Lys Val 
            180                 185                 190         


Gly His Glu Asp Ser Asp Trp Thr Ala Phe Ser Tyr Ser Asn Ala Ser 
        195                 200                 205             


Phe Thr Gln Leu Leu Ser Phe Gly Lys Ala Lys Ser Gly Tyr Phe Leu 
    210                 215                 220                 


Ser Ile Ser Asp Ser Lys Cys Leu Leu Asn Asn Ala Leu Pro Val Lys 
225                 230                 235                 240 


Glu Lys Glu Asp Ile Phe Ala Glu Ser Phe Glu Gln Leu Cys Leu Val 
                245                 250                 255     


Trp Asn Asn Ser Leu Gly Ser Ile Gly Val Asn Phe Lys Arg Asn Tyr 
            260                 265                 270         


Glu Thr Val Pro Cys Asp Ser Thr Ile Ser Lys Val Ile Pro Gly Asn 
        275                 280                 285             


Gly Lys Leu Leu Leu Gly Ser Asn Gln Asn Glu Ile Val Ser Leu Lys 
    290                 295                 300                 


Gly Asp Ile Tyr Asn Phe Arg Leu Trp Asn Phe Thr Met Asn Ala Lys 
305                 310                 315                 320 


Ile Leu Ser Asn Leu Ser Cys Asn Val Lys Gly Asn Val Val Asp Trp 
                325                 330                 335     


Gln Asn Asp Phe Trp Asn Ile Pro Asn Leu Ala Leu Lys Ala Glu Ser 
            340                 345                 350         


Asn Leu Ser Cys Gly Ser Tyr Leu Ile Pro Leu Pro Ala Ala Glu Leu 
        355                 360                 365             


Ala Ser Cys Ala Asp Leu Gly Thr Leu Cys Gln Ala Thr Val Asn Ser 
    370                 375                 380                 


Pro Ser Thr Thr Pro Pro Thr Val Thr Thr Asn Met Pro Val Thr Asn 
385                 390                 395                 400 


Arg Ile Asp Lys Gln Arg Asn Asp Gly Ile Ile Tyr Arg Ile Ser Val 
                405                 410                 415     


Val Ile Gln Asn Ile Leu Arg His Pro Glu Val Lys Val Gln Ser Lys 
            420                 425                 430         


Val Ala Glu Trp Leu Asn Ser Thr Phe Gln Asn Trp Asn Tyr Thr Val 
        435                 440                 445             


Tyr Val Val Asn Ile Ser Phe His Leu Ser Ala Gly Glu Asp Lys Ile 
    450                 455                 460                 


Lys Val Lys Arg Ser Leu Glu Asp Glu Pro Arg Leu Val Leu Trp Ala 
465                 470                 475                 480 


Leu Leu Val Tyr Asn Ala Thr Asn Asn Thr Asn Leu Glu Gly Lys Ile 
                485                 490                 495     


Ile Gln Gln Lys Leu Leu Lys Asn Asn Glu Ser Leu Asp Glu Gly Leu 
            500                 505                 510         


Arg Leu His Thr Val Asn Val Arg Gln Leu Gly His Cys Leu Ala Met 
        515                 520                 525             


Glu Glu Pro Lys Gly Tyr Tyr Trp Pro Ser Ile Gln Pro Ser Glu Tyr 
    530                 535                 540                 


Val Leu Pro Cys Pro Asp Lys Pro Gly Phe Ser Ala Ser Arg Ile Cys 
545                 550                 555                 560 


Phe Tyr Asn Ala Thr Asn Pro Leu Val Thr Tyr Trp Gly Pro Val Asp 
                565                 570                 575     


Ile Ser Asn Cys Leu Lys Glu Ala Asn Glu Val Ala Asn Gln Ile Leu 
            580                 585                 590         


Asn Leu Thr Ala Asp Gly Gln Asn Leu Thr Ser Ala Asn Ile Thr Asn 
        595                 600                 605             


Ile Val Glu Gln Val Lys Arg Ile Val Asn Lys Glu Glu Asn Ile Asp 
    610                 615                 620                 


Ile Thr Leu Gly Ser Thr Leu Met Asn Ile Phe Ser Asn Ile Leu Ser 
625                 630                 635                 640 


Ser Ser Asp Ser Asp Leu Leu Glu Ser Ser Ser Glu Ala Leu Lys Thr 
                645                 650                 655     


Ile Asp Glu Leu Ala Phe Lys Ile Asp Leu Asn Ser Thr Ser His Val 
            660                 665                 670         


Asn Ile Thr Thr Arg Asn Leu Ala Leu Ser Val Ser Ser Leu Leu Pro 
        675                 680                 685             


Gly Thr Asn Ala Ile Ser Asn Phe Ser Ile Gly Leu Pro Ser Asn Asn 
    690                 695                 700                 


Glu Ser Tyr Phe Gln Met Asp Phe Glu Ser Gly Gln Val Asp Pro Leu 
705                 710                 715                 720 


Ala Ser Val Ile Leu Pro Pro Asn Leu Leu Glu Asn Leu Ser Pro Glu 
                725                 730                 735     


Asp Ser Val Leu Val Arg Arg Ala Gln Phe Thr Phe Phe Asn Lys Thr 
            740                 745                 750         


Gly Leu Phe Gln Asp Val Gly Pro Gln Arg Lys Thr Leu Val Ser Tyr 
        755                 760                 765             


Val Met Ala Cys Ser Ile Gly Asn Ile Thr Ile Gln Asn Leu Lys Asp 
    770                 775                 780                 


Pro Val Gln Ile Lys Ile Lys His Thr Arg Thr Gln Glu Val His His 
785                 790                 795                 800 


Pro Ile Cys Ala Phe Trp Asp Leu Asn Lys Asn Lys Ser Phe Gly Gly 
                805                 810                 815     


Trp Asn Thr Ser Gly Cys Val Ala His Arg Asp Ser Asp Ala Ser Glu 
            820                 825                 830         


Thr Val Cys Leu Cys Asn His Phe Thr His Phe Gly Val Leu Met Asp 
        835                 840                 845             


Leu Pro Arg Ser Ala Ser Gln Leu Asp Ala Arg Asn Thr Lys Val Leu 
    850                 855                 860                 


Thr Phe Ile Ser Tyr Ile Gly Cys Gly Ile Ser Ala Ile Phe Ser Ala 
865                 870                 875                 880 


Ala Thr Leu Leu Thr Tyr Val Ala Phe Glu Lys Leu Arg Arg Asp Tyr 
                885                 890                 895     


Pro Ser Lys Ile Leu Met Asn Leu Ser Thr Ala Leu Leu Phe Leu Asn 
            900                 905                 910         


Leu Leu Phe Leu Leu Asp Gly Trp Ile Thr Ser Phe Asn Val Asp Gly 
        915                 920                 925             


Leu Cys Ile Ala Val Ala Val Leu Leu His Phe Phe Leu Leu Ala Thr 
    930                 935                 940                 


Phe Thr Trp Met Gly Leu Glu Ala Ile His Met Tyr Ile Ala Leu Val 
945                 950                 955                 960 


Lys Val Phe Asn Thr Tyr Ile Arg Arg Tyr Ile Leu Lys Phe Cys Ile 
                965                 970                 975     


Ile Gly Trp Gly Leu Pro Ala Leu Val Val Ser Val Val Leu Ala Ser 
            980                 985                 990         


Arg Asn Asn Asn Glu Val Tyr Gly  Lys Glu Ser Tyr Gly  Lys Glu Lys 
        995                 1000                 1005             


Gly Asp  Glu Phe Cys Trp Ile  Gln Asp Pro Val Ile  Phe Tyr Val 
    1010                 1015                 1020             


Thr Cys  Ala Gly Tyr Phe Gly  Val Met Phe Phe Leu  Asn Ile Ala 
    1025                 1030                 1035             


Met Phe  Ile Val Val Met Val  Gln Ile Cys Gly Arg  Asn Gly Lys 
    1040                 1045                 1050             


Arg Ser  Asn Arg Thr Leu Arg  Glu Glu Val Leu Arg  Asn Leu Arg 
    1055                 1060                 1065             


Ser Val  Val Ser Leu Thr Phe  Leu Leu Gly Met Thr  Trp Gly Phe 
    1070                 1075                 1080             


Ala Phe  Phe Ala Trp Gly Pro  Leu Asn Ile Pro Phe  Met Tyr Leu 
    1085                 1090                 1095             


Phe Ser  Ile Phe Asn Ser Leu  Gln Gly Leu Phe Ile  Phe Ile Phe 
    1100                 1105                 1110             


His Cys  Ala Met Lys Glu Asn  Val Gln Lys Gln Trp  Arg Gln His 
    1115                 1120                 1125             


Leu Cys  Cys Gly Arg Phe Arg  Leu Ala Asp Asn Ser  Asp Trp Ser 
    1130                 1135                 1140             


Lys Thr  Ala Thr Asn Ile Ile  Lys Lys Ser Ser Asp  Asn Leu Gly 
    1145                 1150                 1155             


Lys Ser  Leu Ser Ser Ser Ser  Ile Gly Ser Asn Ser  Thr Tyr Leu 
    1160                 1165                 1170             


Thr Ser  Lys Ser Lys Ser Ser  Ser Thr Thr Tyr Phe  Lys Arg Asn 
    1175                 1180                 1185             


Ser His  Thr Asp Asn Val Ser  Tyr Glu His Ser Phe  Asn Lys Ser 
    1190                 1195                 1200             


Gly Ser  Leu Arg Gln Cys Phe  His Gly Gln Val Leu  Val Lys Thr 
    1205                 1210                 1215             


Gly Pro  Cys 
    1220     


<210>  519
<211>  1193
<212>  PRT
<213>  Homo Sapiens

<400>  519

Met Met Phe Arg Ser Asp Arg Met Trp Ser Cys His Trp Lys Trp Lys 
1               5                   10                  15      


Pro Ser Pro Leu Leu Phe Leu Phe Ala Leu Tyr Ile Met Cys Val Pro 
            20                  25                  30          


His Ser Val Trp Gly Cys Ala Asn Cys Arg Val Val Leu Ser Asn Pro 
        35                  40                  45              


Ser Gly Thr Phe Thr Ser Pro Cys Tyr Pro Asn Asp Tyr Pro Asn Ser 
    50                  55                  60                  


Gln Ala Cys Met Trp Thr Leu Arg Ala Pro Thr Gly Tyr Ile Ile Gln 
65                  70                  75                  80  


Ile Thr Phe Asn Asp Phe Asp Ile Glu Glu Ala Pro Asn Cys Ile Tyr 
                85                  90                  95      


Asp Ser Leu Ser Leu Asp Asn Gly Glu Ser Gln Thr Lys Phe Cys Gly 
            100                 105                 110         


Ala Thr Ala Lys Gly Leu Ser Phe Asn Ser Ser Ala Asn Glu Met His 
        115                 120                 125             


Val Ser Phe Ser Ser Asp Phe Ser Ile Gln Lys Lys Gly Phe Asn Ala 
    130                 135                 140                 


Ser Tyr Ile Arg Val Ala Val Ser Leu Arg Asn Gln Lys Val Ile Leu 
145                 150                 155                 160 


Pro Gln Thr Ser Asp Ala Tyr Gln Val Ser Val Ala Lys Ser Ile Ser 
                165                 170                 175     


Ile Pro Glu Leu Ser Ala Phe Thr Leu Cys Phe Glu Ala Thr Lys Val 
            180                 185                 190         


Gly His Glu Asp Ser Asp Trp Thr Ala Phe Ser Tyr Ser Asn Ala Ser 
        195                 200                 205             


Phe Thr Gln Leu Leu Ser Phe Gly Lys Ala Lys Ser Gly Tyr Phe Leu 
    210                 215                 220                 


Ser Ile Ser Asp Ser Lys Cys Leu Leu Asn Asn Ala Leu Pro Val Lys 
225                 230                 235                 240 


Glu Lys Glu Asp Ile Phe Ala Glu Ser Phe Glu Gln Leu Cys Leu Val 
                245                 250                 255     


Trp Asn Asn Ser Leu Gly Ser Ile Gly Val Asn Phe Lys Arg Asn Tyr 
            260                 265                 270         


Glu Thr Val Pro Cys Asp Ser Thr Ile Ser Lys Val Ile Pro Gly Asn 
        275                 280                 285             


Gly Lys Leu Leu Leu Gly Ser Asn Gln Asn Glu Ile Val Ser Leu Lys 
    290                 295                 300                 


Gly Asp Ile Tyr Asn Phe Arg Leu Trp Asn Phe Thr Met Asn Ala Lys 
305                 310                 315                 320 


Ile Leu Ser Asn Leu Ser Cys Asn Val Lys Gly Asn Val Val Asp Trp 
                325                 330                 335     


Gln Asn Asp Phe Trp Asn Ile Pro Asn Leu Ala Leu Lys Ala Glu Ser 
            340                 345                 350         


Asn Leu Ser Cys Gly Ser Tyr Leu Ile Pro Leu Pro Ala Ala Glu Leu 
        355                 360                 365             


Ala Ser Cys Ala Asp Leu Gly Thr Leu Cys Gln Asp Gly Ile Ile Tyr 
    370                 375                 380                 


Arg Ile Ser Val Val Ile Gln Asn Ile Leu Arg His Pro Glu Val Lys 
385                 390                 395                 400 


Val Gln Ser Lys Val Ala Glu Trp Leu Asn Ser Thr Phe Gln Asn Trp 
                405                 410                 415     


Asn Tyr Thr Val Tyr Val Val Asn Ile Ser Phe His Leu Ser Ala Gly 
            420                 425                 430         


Glu Asp Lys Ile Lys Val Lys Arg Ser Leu Glu Asp Glu Pro Arg Leu 
        435                 440                 445             


Val Leu Trp Ala Leu Leu Val Tyr Asn Ala Thr Asn Asn Thr Asn Leu 
    450                 455                 460                 


Glu Gly Lys Ile Ile Gln Gln Lys Leu Leu Lys Asn Asn Glu Ser Leu 
465                 470                 475                 480 


Asp Glu Gly Leu Arg Leu His Thr Val Asn Val Arg Gln Leu Gly His 
                485                 490                 495     


Cys Leu Ala Met Glu Glu Pro Lys Gly Tyr Tyr Trp Pro Ser Ile Gln 
            500                 505                 510         


Pro Ser Glu Tyr Val Leu Pro Cys Pro Asp Lys Pro Gly Phe Ser Ala 
        515                 520                 525             


Ser Arg Ile Cys Phe Tyr Asn Ala Thr Asn Pro Leu Val Thr Tyr Trp 
    530                 535                 540                 


Gly Pro Val Asp Ile Ser Asn Cys Leu Lys Glu Ala Asn Glu Val Ala 
545                 550                 555                 560 


Asn Gln Ile Leu Asn Leu Thr Ala Asp Gly Gln Asn Leu Thr Ser Ala 
                565                 570                 575     


Asn Ile Thr Asn Ile Val Glu Gln Val Lys Arg Ile Val Asn Lys Glu 
            580                 585                 590         


Glu Asn Ile Asp Ile Thr Leu Gly Ser Thr Leu Met Asn Ile Phe Ser 
        595                 600                 605             


Asn Ile Leu Ser Ser Ser Asp Ser Asp Leu Leu Glu Ser Ser Ser Glu 
    610                 615                 620                 


Ala Leu Lys Thr Ile Asp Glu Leu Ala Phe Lys Ile Asp Leu Asn Ser 
625                 630                 635                 640 


Thr Ser His Val Asn Ile Thr Thr Arg Asn Leu Ala Leu Ser Val Ser 
                645                 650                 655     


Ser Leu Leu Pro Gly Thr Asn Ala Ile Ser Asn Phe Ser Ile Gly Leu 
            660                 665                 670         


Pro Ser Asn Asn Glu Ser Tyr Phe Gln Met Asp Phe Glu Ser Gly Gln 
        675                 680                 685             


Val Asp Pro Leu Ala Ser Val Ile Leu Pro Pro Asn Leu Leu Glu Asn 
    690                 695                 700                 


Leu Ser Pro Glu Asp Ser Val Leu Val Arg Arg Ala Gln Phe Thr Phe 
705                 710                 715                 720 


Phe Asn Lys Thr Gly Leu Phe Gln Asp Val Gly Pro Gln Arg Lys Thr 
                725                 730                 735     


Leu Val Ser Tyr Val Met Ala Cys Ser Ile Gly Asn Ile Thr Ile Gln 
            740                 745                 750         


Asn Leu Lys Asp Pro Val Gln Ile Lys Ile Lys His Thr Arg Thr Gln 
        755                 760                 765             


Glu Val His His Pro Ile Cys Ala Phe Trp Asp Leu Asn Lys Asn Lys 
    770                 775                 780                 


Ser Phe Gly Gly Trp Asn Thr Ser Gly Cys Val Ala His Arg Asp Ser 
785                 790                 795                 800 


Asp Ala Ser Glu Thr Val Cys Leu Cys Asn His Phe Thr His Phe Gly 
                805                 810                 815     


Val Leu Met Asp Leu Pro Arg Ser Ala Ser Gln Leu Asp Ala Arg Asn 
            820                 825                 830         


Thr Lys Val Leu Thr Phe Ile Ser Tyr Ile Gly Cys Gly Ile Ser Ala 
        835                 840                 845             


Ile Phe Ser Ala Ala Thr Leu Leu Thr Tyr Val Ala Phe Glu Lys Leu 
    850                 855                 860                 


Arg Arg Asp Tyr Pro Ser Lys Ile Leu Met Asn Leu Ser Thr Ala Leu 
865                 870                 875                 880 


Leu Phe Leu Asn Leu Leu Phe Leu Leu Asp Gly Trp Ile Thr Ser Phe 
                885                 890                 895     


Asn Val Asp Gly Leu Cys Ile Ala Val Ala Val Leu Leu His Phe Phe 
            900                 905                 910         


Leu Leu Ala Thr Phe Thr Trp Met Gly Leu Glu Ala Ile His Met Tyr 
        915                 920                 925             


Ile Ala Leu Val Lys Val Phe Asn Thr Tyr Ile Arg Arg Tyr Ile Leu 
    930                 935                 940                 


Lys Phe Cys Ile Ile Gly Trp Gly Leu Pro Ala Leu Val Val Ser Val 
945                 950                 955                 960 


Val Leu Ala Ser Arg Asn Asn Asn Glu Val Tyr Gly Lys Glu Ser Tyr 
                965                 970                 975     


Gly Lys Glu Lys Gly Asp Glu Phe Cys Trp Ile Gln Asp Pro Val Ile 
            980                 985                 990         


Phe Tyr Val Thr Cys Ala Gly Tyr  Phe Gly Val Met Phe  Phe Leu Asn 
        995                 1000                 1005             


Ile Ala  Met Phe Ile Val Val  Met Val Gln Ile Cys  Gly Arg Asn 
    1010                 1015                 1020             


Gly Lys  Arg Ser Asn Arg Thr  Leu Arg Glu Glu Val  Leu Arg Asn 
    1025                 1030                 1035             


Leu Arg  Ser Val Val Ser Leu  Thr Phe Leu Leu Gly  Met Thr Trp 
    1040                 1045                 1050             


Gly Phe  Ala Phe Phe Ala Trp  Gly Pro Leu Asn Ile  Pro Phe Met 
    1055                 1060                 1065             


Tyr Leu  Phe Ser Ile Phe Asn  Ser Leu Gln Gly Leu  Phe Ile Phe 
    1070                 1075                 1080             


Ile Phe  His Cys Ala Met Lys  Glu Asn Val Gln Lys  Gln Trp Arg 
    1085                 1090                 1095             


Gln His  Leu Cys Cys Gly Arg  Phe Arg Leu Ala Asp  Asn Ser Asp 
    1100                 1105                 1110             


Trp Ser  Lys Thr Ala Thr Asn  Ile Ile Lys Lys Ser  Ser Asp Asn 
    1115                 1120                 1125             


Leu Gly  Lys Ser Leu Ser Ser  Ser Ser Ile Gly Ser  Asn Ser Thr 
    1130                 1135                 1140             


Tyr Leu  Thr Ser Lys Ser Lys  Ser Ser Ser Thr Thr  Tyr Phe Lys 
    1145                 1150                 1155             


Arg Asn  Ser His Thr Asp Asn  Val Ser Tyr Glu His  Ser Phe Asn 
    1160                 1165                 1170             


Lys Ser  Gly Ser Leu Arg Gln  Cys Phe His Gly Gln  Val Leu Val 
    1175                 1180                 1185             


Lys Thr  Gly Pro Cys 
    1190             


<210>  520
<211>  1250
<212>  PRT
<213>  Homo Sapiens

<400>  520

Met Met Phe Arg Ser Asp Arg Met Trp Ser Cys His Trp Lys Trp Lys 
1               5                   10                  15      


Pro Ser Pro Leu Leu Phe Leu Phe Ala Leu Tyr Ile Met Cys Val Pro 
            20                  25                  30          


His Ser Val Trp Gly Cys Ala Asn Cys Arg Val Val Leu Ser Asn Pro 
        35                  40                  45              


Ser Gly Thr Phe Thr Ser Pro Cys Tyr Pro Asn Asp Tyr Pro Asn Ser 
    50                  55                  60                  


Gln Ala Cys Met Trp Thr Leu Arg Ala Pro Thr Gly Tyr Ile Ile Gln 
65                  70                  75                  80  


Ile Thr Phe Asn Asp Phe Asp Ile Glu Glu Ala Pro Asn Cys Ile Tyr 
                85                  90                  95      


Asp Ser Leu Ser Leu Asp Asn Gly Glu Ser Gln Thr Lys Phe Cys Gly 
            100                 105                 110         


Ala Thr Ala Lys Gly Leu Ser Phe Asn Ser Ser Ala Asn Glu Met His 
        115                 120                 125             


Val Ser Phe Ser Ser Asp Phe Ser Ile Gln Lys Lys Gly Phe Asn Ala 
    130                 135                 140                 


Ser Tyr Ile Arg Val Ala Val Ser Leu Arg Asn Gln Lys Val Ile Leu 
145                 150                 155                 160 


Pro Gln Thr Ser Asp Ala Tyr Gln Val Ser Val Ala Lys Ser Ile Ser 
                165                 170                 175     


Ile Pro Glu Leu Ser Ala Phe Thr Leu Cys Phe Glu Ala Thr Lys Val 
            180                 185                 190         


Gly His Glu Asp Ser Asp Trp Thr Ala Phe Ser Tyr Ser Asn Ala Ser 
        195                 200                 205             


Phe Thr Gln Leu Leu Ser Phe Gly Lys Ala Lys Ser Gly Tyr Phe Leu 
    210                 215                 220                 


Ser Ile Ser Asp Ser Lys Cys Leu Leu Asn Asn Ala Leu Pro Val Lys 
225                 230                 235                 240 


Glu Lys Glu Asp Ile Phe Ala Glu Ser Phe Glu Gln Leu Cys Leu Val 
                245                 250                 255     


Trp Asn Asn Ser Leu Gly Ser Ile Gly Val Asn Phe Lys Arg Asn Tyr 
            260                 265                 270         


Glu Thr Val Pro Cys Asp Ser Thr Ile Ser Lys Val Ile Pro Gly Asn 
        275                 280                 285             


Gly Lys Leu Leu Leu Gly Ser Asn Gln Asn Glu Ile Val Ser Leu Lys 
    290                 295                 300                 


Gly Asp Ile Tyr Asn Phe Arg Leu Trp Asn Phe Thr Met Asn Ala Lys 
305                 310                 315                 320 


Ile Leu Ser Asn Leu Ser Cys Asn Val Lys Gly Asn Val Val Asp Trp 
                325                 330                 335     


Gln Asn Asp Phe Trp Asn Ile Pro Asn Leu Ala Leu Lys Ala Glu Ser 
            340                 345                 350         


Asn Leu Ser Cys Gly Ser Tyr Leu Ile Pro Leu Pro Ala Ala Glu Leu 
        355                 360                 365             


Ala Ser Cys Ala Asp Leu Gly Thr Leu Cys Gln Ala Thr Val Asn Ser 
    370                 375                 380                 


Pro Ser Thr Thr Pro Pro Thr Val Thr Thr Asn Met Pro Val Thr Asn 
385                 390                 395                 400 


Arg Ile Asp Lys Gln Arg Asn Asp Gly Ile Ile Tyr Arg Ile Ser Val 
                405                 410                 415     


Val Ile Gln Asn Ile Leu Arg His Pro Glu Val Lys Val Gln Ser Lys 
            420                 425                 430         


Val Ala Glu Trp Leu Asn Ser Thr Phe Gln Asn Trp Asn Tyr Thr Val 
        435                 440                 445             


Tyr Val Val Asn Ile Ser Phe His Leu Ser Ala Gly Glu Asp Lys Ile 
    450                 455                 460                 


Lys Val Lys Arg Ser Leu Glu Asp Glu Pro Arg Leu Val Leu Trp Ala 
465                 470                 475                 480 


Leu Leu Val Tyr Asn Ala Thr Asn Asn Thr Asn Leu Glu Gly Lys Ile 
                485                 490                 495     


Ile Gln Gln Lys Leu Leu Lys Asn Asn Glu Ser Leu Asp Glu Gly Leu 
            500                 505                 510         


Arg Leu His Thr Val Asn Val Arg Gln Leu Gly His Cys Leu Ala Met 
        515                 520                 525             


Glu Glu Pro Lys Gly Tyr Tyr Trp Pro Ser Ile Gln Pro Ser Glu Tyr 
    530                 535                 540                 


Val Leu Pro Cys Pro Asp Lys Pro Gly Phe Ser Ala Ser Arg Ile Cys 
545                 550                 555                 560 


Phe Tyr Asn Ala Thr Asn Pro Leu Val Thr Tyr Trp Gly Pro Val Asp 
                565                 570                 575     


Ile Ser Asn Cys Leu Lys Glu Ala Asn Glu Val Ala Asn Gln Ile Leu 
            580                 585                 590         


Asn Leu Thr Ala Asp Gly Gln Asn Leu Thr Ser Ala Asn Ile Thr Asn 
        595                 600                 605             


Ile Val Glu Gln Val Lys Arg Ile Val Asn Lys Glu Glu Asn Ile Asp 
    610                 615                 620                 


Ile Thr Leu Gly Ser Thr Leu Met Asn Ile Phe Ser Asn Ile Leu Ser 
625                 630                 635                 640 


Ser Ser Asp Ser Asp Leu Leu Glu Ser Ser Ser Glu Ala Leu Lys Thr 
                645                 650                 655     


Ile Asp Glu Leu Ala Phe Lys Ile Asp Leu Asn Ser Thr Ser His Val 
            660                 665                 670         


Asn Ile Thr Thr Arg Asn Leu Ala Leu Ser Val Ser Ser Leu Leu Pro 
        675                 680                 685             


Gly Thr Asn Ala Ile Ser Asn Phe Ser Ile Gly Leu Pro Ser Asn Asn 
    690                 695                 700                 


Glu Ser Tyr Phe Gln Met Asp Phe Glu Ser Gly Gln Val Asp Pro Leu 
705                 710                 715                 720 


Ala Ser Val Ile Leu Pro Pro Asn Leu Leu Glu Asn Leu Ser Pro Glu 
                725                 730                 735     


Asp Ser Val Leu Val Arg Arg Ala Gln Phe Thr Phe Phe Asn Lys Thr 
            740                 745                 750         


Gly Leu Phe Gln Asp Val Gly Pro Gln Arg Lys Thr Leu Val Ser Tyr 
        755                 760                 765             


Val Met Ala Cys Ser Ile Gly Asn Ile Thr Ile Gln Asn Leu Lys Asp 
    770                 775                 780                 


Pro Val Gln Ile Lys Ile Lys His Thr Arg Thr Gln Glu Val His His 
785                 790                 795                 800 


Pro Ile Cys Ala Phe Trp Asp Leu Asn Lys Asn Lys Ser Phe Gly Gly 
                805                 810                 815     


Trp Asn Thr Ser Gly Cys Val Ala His Arg Asp Ser Asp Ala Ser Glu 
            820                 825                 830         


Thr Val Cys Leu Cys Asn His Phe Thr His Phe Gly Val Leu Met Asp 
        835                 840                 845             


Leu Pro Arg Ser Ala Ser Gln Leu Asp Ala Arg Asn Thr Lys Val Leu 
    850                 855                 860                 


Thr Phe Ile Ser Tyr Ile Gly Cys Gly Ile Ser Ala Ile Phe Ser Ala 
865                 870                 875                 880 


Ala Thr Leu Leu Thr Tyr Val Ala Phe Glu Lys Leu Arg Arg Asp Tyr 
                885                 890                 895     


Pro Ser Lys Ile Leu Met Asn Leu Ser Thr Ala Leu Leu Phe Leu Asn 
            900                 905                 910         


Leu Leu Phe Leu Leu Asp Gly Trp Ile Thr Ser Phe Asn Val Asp Gly 
        915                 920                 925             


Leu Cys Ile Ala Val Ala Val Leu Leu His Phe Phe Leu Leu Ala Thr 
    930                 935                 940                 


Phe Thr Trp Met Gly Leu Glu Ala Ile His Met Tyr Ile Ala Leu Val 
945                 950                 955                 960 


Lys Val Phe Asn Thr Tyr Ile Arg Arg Tyr Ile Leu Lys Phe Cys Ile 
                965                 970                 975     


Ile Gly Trp Gly Leu Pro Ala Leu Val Val Ser Val Val Leu Ala Ser 
            980                 985                 990         


Arg Asn Asn Asn Glu Val Tyr Gly  Lys Glu Ser Tyr Gly  Lys Glu Lys 
        995                 1000                 1005             


Gly Asp  Glu Phe Cys Trp Ile  Gln Asp Pro Val Ile  Phe Tyr Val 
    1010                 1015                 1020             


Thr Cys  Ala Gly Tyr Phe Gly  Val Met Phe Phe Leu  Asn Ile Ala 
    1025                 1030                 1035             


Met Phe  Ile Val Val Met Val  Gln Ile Cys Gly Arg  Asn Gly Lys 
    1040                 1045                 1050             


Arg Ser  Asn Arg Thr Leu Arg  Glu Glu Val Leu Arg  Asn Leu Arg 
    1055                 1060                 1065             


Ser Val  Val Ser Leu Thr Phe  Leu Leu Gly Met Thr  Trp Gly Phe 
    1070                 1075                 1080             


Ala Phe  Phe Ala Trp Gly Pro  Leu Asn Ile Pro Phe  Met Tyr Leu 
    1085                 1090                 1095             


Phe Ser  Ile Phe Asn Ser Leu  Gln Gly Leu Phe Ile  Phe Ile Phe 
    1100                 1105                 1110             


His Cys  Ala Met Lys Glu Asn  Val Gln Lys Gln Trp  Arg Gln His 
    1115                 1120                 1125             


Leu Cys  Cys Gly Arg Phe Arg  Leu Ala Asp Asn Ser  Asp Trp Ser 
    1130                 1135                 1140             


Lys Thr  Ala Thr Asn Ile Ile  Lys Lys Ser Ser Asp  Asn Leu Gly 
    1145                 1150                 1155             


Lys Ser  Leu Ser Ser Ser Ser  Ile Gly Ser Asn Ser  Thr Tyr Leu 
    1160                 1165                 1170             


Thr Ser  Lys Ser Lys Ser Ser  Ser Thr Thr Tyr Phe  Lys Arg Asn 
    1175                 1180                 1185             


Ser His  Thr Asp Ser Ala Ser  Met Asp Lys Ser Leu  Ser Lys Leu 
    1190                 1195                 1200             


Ala His  Ala Asp Gly Asp Gln  Thr Ser Ile Ile Pro  Val His Gln 
    1205                 1210                 1215             


Val Ile  Asp Lys Val Lys Gly  Tyr Cys Asn Ala His  Ser Asp Asn 
    1220                 1225                 1230             


Phe Tyr  Lys Asn Ile Ile Met  Ser Asp Thr Phe Ser  His Ser Thr 
    1235                 1240                 1245             


Lys Phe  
    1250 


<210>  521
<211>  1222
<212>  PRT
<213>  Homo Sapiens

<400>  521

Met Met Phe Arg Ser Asp Arg Met Trp Ser Cys His Trp Lys Trp Lys 
1               5                   10                  15      


Pro Ser Pro Leu Leu Phe Leu Phe Ala Leu Tyr Ile Met Cys Val Pro 
            20                  25                  30          


His Ser Val Trp Gly Cys Ala Asn Cys Arg Val Val Leu Ser Asn Pro 
        35                  40                  45              


Ser Gly Thr Phe Thr Ser Pro Cys Tyr Pro Asn Asp Tyr Pro Asn Ser 
    50                  55                  60                  


Gln Ala Cys Met Trp Thr Leu Arg Ala Pro Thr Gly Tyr Ile Ile Gln 
65                  70                  75                  80  


Ile Thr Phe Asn Asp Phe Asp Ile Glu Glu Ala Pro Asn Cys Ile Tyr 
                85                  90                  95      


Asp Ser Leu Ser Leu Asp Asn Gly Glu Ser Gln Thr Lys Phe Cys Gly 
            100                 105                 110         


Ala Thr Ala Lys Gly Leu Ser Phe Asn Ser Ser Ala Asn Glu Met His 
        115                 120                 125             


Val Ser Phe Ser Ser Asp Phe Ser Ile Gln Lys Lys Gly Phe Asn Ala 
    130                 135                 140                 


Ser Tyr Ile Arg Val Ala Val Ser Leu Arg Asn Gln Lys Val Ile Leu 
145                 150                 155                 160 


Pro Gln Thr Ser Asp Ala Tyr Gln Val Ser Val Ala Lys Ser Ile Ser 
                165                 170                 175     


Ile Pro Glu Leu Ser Ala Phe Thr Leu Cys Phe Glu Ala Thr Lys Val 
            180                 185                 190         


Gly His Glu Asp Ser Asp Trp Thr Ala Phe Ser Tyr Ser Asn Ala Ser 
        195                 200                 205             


Phe Thr Gln Leu Leu Ser Phe Gly Lys Ala Lys Ser Gly Tyr Phe Leu 
    210                 215                 220                 


Ser Ile Ser Asp Ser Lys Cys Leu Leu Asn Asn Ala Leu Pro Val Lys 
225                 230                 235                 240 


Glu Lys Glu Asp Ile Phe Ala Glu Ser Phe Glu Gln Leu Cys Leu Val 
                245                 250                 255     


Trp Asn Asn Ser Leu Gly Ser Ile Gly Val Asn Phe Lys Arg Asn Tyr 
            260                 265                 270         


Glu Thr Val Pro Cys Asp Ser Thr Ile Ser Lys Val Ile Pro Gly Asn 
        275                 280                 285             


Gly Lys Leu Leu Leu Gly Ser Asn Gln Asn Glu Ile Val Ser Leu Lys 
    290                 295                 300                 


Gly Asp Ile Tyr Asn Phe Arg Leu Trp Asn Phe Thr Met Asn Ala Lys 
305                 310                 315                 320 


Ile Leu Ser Asn Leu Ser Cys Asn Val Lys Gly Asn Val Val Asp Trp 
                325                 330                 335     


Gln Asn Asp Phe Trp Asn Ile Pro Asn Leu Ala Leu Lys Ala Glu Ser 
            340                 345                 350         


Asn Leu Ser Cys Gly Ser Tyr Leu Ile Pro Leu Pro Ala Ala Glu Leu 
        355                 360                 365             


Ala Ser Cys Ala Asp Leu Gly Thr Leu Cys Gln Asp Gly Ile Ile Tyr 
    370                 375                 380                 


Arg Ile Ser Val Val Ile Gln Asn Ile Leu Arg His Pro Glu Val Lys 
385                 390                 395                 400 


Val Gln Ser Lys Val Ala Glu Trp Leu Asn Ser Thr Phe Gln Asn Trp 
                405                 410                 415     


Asn Tyr Thr Val Tyr Val Val Asn Ile Ser Phe His Leu Ser Ala Gly 
            420                 425                 430         


Glu Asp Lys Ile Lys Val Lys Arg Ser Leu Glu Asp Glu Pro Arg Leu 
        435                 440                 445             


Val Leu Trp Ala Leu Leu Val Tyr Asn Ala Thr Asn Asn Thr Asn Leu 
    450                 455                 460                 


Glu Gly Lys Ile Ile Gln Gln Lys Leu Leu Lys Asn Asn Glu Ser Leu 
465                 470                 475                 480 


Asp Glu Gly Leu Arg Leu His Thr Val Asn Val Arg Gln Leu Gly His 
                485                 490                 495     


Cys Leu Ala Met Glu Glu Pro Lys Gly Tyr Tyr Trp Pro Ser Ile Gln 
            500                 505                 510         


Pro Ser Glu Tyr Val Leu Pro Cys Pro Asp Lys Pro Gly Phe Ser Ala 
        515                 520                 525             


Ser Arg Ile Cys Phe Tyr Asn Ala Thr Asn Pro Leu Val Thr Tyr Trp 
    530                 535                 540                 


Gly Pro Val Asp Ile Ser Asn Cys Leu Lys Glu Ala Asn Glu Val Ala 
545                 550                 555                 560 


Asn Gln Ile Leu Asn Leu Thr Ala Asp Gly Gln Asn Leu Thr Ser Ala 
                565                 570                 575     


Asn Ile Thr Asn Ile Val Glu Gln Val Lys Arg Ile Val Asn Lys Glu 
            580                 585                 590         


Glu Asn Ile Asp Ile Thr Leu Gly Ser Thr Leu Met Asn Ile Phe Ser 
        595                 600                 605             


Asn Ile Leu Ser Ser Ser Asp Ser Asp Leu Leu Glu Ser Ser Ser Glu 
    610                 615                 620                 


Ala Leu Lys Thr Ile Asp Glu Leu Ala Phe Lys Ile Asp Leu Asn Ser 
625                 630                 635                 640 


Thr Ser His Val Asn Ile Thr Thr Arg Asn Leu Ala Leu Ser Val Ser 
                645                 650                 655     


Ser Leu Leu Pro Gly Thr Asn Ala Ile Ser Asn Phe Ser Ile Gly Leu 
            660                 665                 670         


Pro Ser Asn Asn Glu Ser Tyr Phe Gln Met Asp Phe Glu Ser Gly Gln 
        675                 680                 685             


Val Asp Pro Leu Ala Ser Val Ile Leu Pro Pro Asn Leu Leu Glu Asn 
    690                 695                 700                 


Leu Ser Pro Glu Asp Ser Val Leu Val Arg Arg Ala Gln Phe Thr Phe 
705                 710                 715                 720 


Phe Asn Lys Thr Gly Leu Phe Gln Asp Val Gly Pro Gln Arg Lys Thr 
                725                 730                 735     


Leu Val Ser Tyr Val Met Ala Cys Ser Ile Gly Asn Ile Thr Ile Gln 
            740                 745                 750         


Asn Leu Lys Asp Pro Val Gln Ile Lys Ile Lys His Thr Arg Thr Gln 
        755                 760                 765             


Glu Val His His Pro Ile Cys Ala Phe Trp Asp Leu Asn Lys Asn Lys 
    770                 775                 780                 


Ser Phe Gly Gly Trp Asn Thr Ser Gly Cys Val Ala His Arg Asp Ser 
785                 790                 795                 800 


Asp Ala Ser Glu Thr Val Cys Leu Cys Asn His Phe Thr His Phe Gly 
                805                 810                 815     


Val Leu Met Asp Leu Pro Arg Ser Ala Ser Gln Leu Asp Ala Arg Asn 
            820                 825                 830         


Thr Lys Val Leu Thr Phe Ile Ser Tyr Ile Gly Cys Gly Ile Ser Ala 
        835                 840                 845             


Ile Phe Ser Ala Ala Thr Leu Leu Thr Tyr Val Ala Phe Glu Lys Leu 
    850                 855                 860                 


Arg Arg Asp Tyr Pro Ser Lys Ile Leu Met Asn Leu Ser Thr Ala Leu 
865                 870                 875                 880 


Leu Phe Leu Asn Leu Leu Phe Leu Leu Asp Gly Trp Ile Thr Ser Phe 
                885                 890                 895     


Asn Val Asp Gly Leu Cys Ile Ala Val Ala Val Leu Leu His Phe Phe 
            900                 905                 910         


Leu Leu Ala Thr Phe Thr Trp Met Gly Leu Glu Ala Ile His Met Tyr 
        915                 920                 925             


Ile Ala Leu Val Lys Val Phe Asn Thr Tyr Ile Arg Arg Tyr Ile Leu 
    930                 935                 940                 


Lys Phe Cys Ile Ile Gly Trp Gly Leu Pro Ala Leu Val Val Ser Val 
945                 950                 955                 960 


Val Leu Ala Ser Arg Asn Asn Asn Glu Val Tyr Gly Lys Glu Ser Tyr 
                965                 970                 975     


Gly Lys Glu Lys Gly Asp Glu Phe Cys Trp Ile Gln Asp Pro Val Ile 
            980                 985                 990         


Phe Tyr Val Thr Cys Ala Gly Tyr  Phe Gly Val Met Phe  Phe Leu Asn 
        995                 1000                 1005             


Ile Ala  Met Phe Ile Val Val  Met Val Gln Ile Cys  Gly Arg Asn 
    1010                 1015                 1020             


Gly Lys  Arg Ser Asn Arg Thr  Leu Arg Glu Glu Val  Leu Arg Asn 
    1025                 1030                 1035             


Leu Arg  Ser Val Val Ser Leu  Thr Phe Leu Leu Gly  Met Thr Trp 
    1040                 1045                 1050             


Gly Phe  Ala Phe Phe Ala Trp  Gly Pro Leu Asn Ile  Pro Phe Met 
    1055                 1060                 1065             


Tyr Leu  Phe Ser Ile Phe Asn  Ser Leu Gln Gly Leu  Phe Ile Phe 
    1070                 1075                 1080             


Ile Phe  His Cys Ala Met Lys  Glu Asn Val Gln Lys  Gln Trp Arg 
    1085                 1090                 1095             


Gln His  Leu Cys Cys Gly Arg  Phe Arg Leu Ala Asp  Asn Ser Asp 
    1100                 1105                 1110             


Trp Ser  Lys Thr Ala Thr Asn  Ile Ile Lys Lys Ser  Ser Asp Asn 
    1115                 1120                 1125             


Leu Gly  Lys Ser Leu Ser Ser  Ser Ser Ile Gly Ser  Asn Ser Thr 
    1130                 1135                 1140             


Tyr Leu  Thr Ser Lys Ser Lys  Ser Ser Ser Thr Thr  Tyr Phe Lys 
    1145                 1150                 1155             


Arg Asn  Ser His Thr Asp Ser  Ala Ser Met Asp Lys  Ser Leu Ser 
    1160                 1165                 1170             


Lys Leu  Ala His Ala Asp Gly  Asp Gln Thr Ser Ile  Ile Pro Val 
    1175                 1180                 1185             


His Gln  Val Ile Asp Lys Val  Lys Gly Tyr Cys Asn  Ala His Ser 
    1190                 1195                 1200             


Asp Asn  Phe Tyr Lys Asn Ile  Ile Met Ser Asp Thr  Phe Ser His 
    1205                 1210                 1215             


Ser Thr  Lys Phe 
    1220         


<210>  522
<211>  103
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  522

Xaa Leu Gly Ser Thr Leu Met Asn Ile Phe Ser Asn Ile Leu Ser Ser 
1               5                   10                  15      


Ser Asp Ser Asp Leu Leu Glu Ser Ser Ser Glu Ala Leu Lys Thr Ile 
            20                  25                  30          


Asp Glu Leu Ala Phe Lys Ile Asp Leu Asn Ser Thr Ser His Val Asn 
        35                  40                  45              


Ile Thr Thr Arg Asn Leu Ala Leu Ser Val Ser Ser Leu Leu Pro Gly 
    50                  55                  60                  


Thr Asn Ala Ile Ser Asn Phe Ser Ile Gly Leu Pro Ser Asn Asn Glu 
65                  70                  75                  80  


Ser Tyr Phe Gln Leu Leu Ser Phe Thr Thr Cys Phe Glu Lys Thr Ser 
                85                  90                  95      


Lys Ser Ala Ala Asp Gly Phe 
            100             


<210>  523
<211>  135
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  523

Xaa Val Lys Val Gln Ser Lys Val Ala Glu Trp Leu Asn Ser Thr Phe 
1               5                   10                  15      


Gln Asn Trp Asn Tyr Thr Val Tyr Val Val Asn Ile Ser Phe His Leu 
            20                  25                  30          


Ser Ala Gly Glu Asp Lys Ile Lys Val Lys Arg Ser Leu Glu Asp Glu 
        35                  40                  45              


Pro Arg Leu Val Leu Trp Ala Leu Leu Val Tyr Asn Ala Thr Asn Asn 
    50                  55                  60                  


Thr Asn Leu Glu Gly Lys Ile Ile Gln Gln Lys Leu Leu Lys Asn Asn 
65                  70                  75                  80  


Glu Ser Leu Asp Glu Gly Leu Arg Leu His Thr Val Asn Val Arg Gln 
                85                  90                  95      


Leu Gly His Cys Leu Ala Met Glu Glu Pro Lys Gly Tyr Tyr Trp Pro 
            100                 105                 110         


Ser Ile Gln Pro Ser Glu Tyr Val Leu Pro Cys Pro Asp Lys Pro Gly 
        115                 120                 125             


Phe Ser Ala Ser Arg Ile Trp 
    130                 135 


<210>  524
<211>  73
<212>  PRT
<213>  Homo Sapiens

<400>  524

Gly Gln Asn Leu Ile Arg Ser Ile Gln Ile Asn Ile Thr Arg Leu Ala 
1               5                   10                  15      


Gly Thr Phe Gly Asp Val Ala Val Gly Leu Arg Ile Ser Ser Asp His 
            20                  25                  30          


Lys Glu Gln Pro Ile Val Thr Glu Asn Ala Glu Arg Gln Leu Val Val 
        35                  40                  45              


Lys Asp Gly Ala Thr Tyr Lys Val Asp Val Val Pro Ile Lys Asn Gln 
    50                  55                  60                  


Val Val Gly Cys Gln Ser Leu Pro Trp 
65                  70              


<210>  525
<211>  123
<212>  PRT
<213>  Homo Sapiens

<400>  525

Met Ala Ala Val Thr His Tyr Leu Tyr Leu Cys Gln Phe Ser Trp Met 
1               5                   10                  15      


Leu Ile Gln Ser Val Asn Phe Trp Tyr Val Leu Val Met Asn Asp Glu 
            20                  25                  30          


His Thr Glu Arg Arg Tyr Leu Leu Phe Phe Leu Leu Ser Trp Gly Leu 
        35                  40                  45              


Pro Ala Phe Val Val Ile Leu Leu Ile Val Ile Leu Lys Gly Ile Tyr 
    50                  55                  60                  


His Gln Ser Met Ser Gln Ile Tyr Gly Leu Ile His Gly Asp Leu Cys 
65                  70                  75                  80  


Phe Ile Pro Asn Val Tyr Ala Ala Leu Phe Thr Ala Ala Leu Val Pro 
                85                  90                  95      


Leu Thr Cys Leu Val Val Val Phe Val Val Phe Ile His Ala Tyr Gln 
            100                 105                 110         


Val Lys Pro Gln Trp Lys Ala Tyr Asp Asp Val 
        115                 120             


<210>  526
<211>  123
<212>  PRT
<213>  Homo Sapiens

<400>  526

Met Ala Ala Val Thr His Tyr Leu Tyr Leu Cys Gln Phe Ser Trp Met 
1               5                   10                  15      


Leu Ile Gln Ser Val Asn Phe Trp Tyr Val Leu Val Met Asn Asp Glu 
            20                  25                  30          


His Thr Glu Arg Arg Tyr Leu Leu Phe Phe Leu Leu Ser Trp Gly Leu 
        35                  40                  45              


Pro Ala Phe Val Val Ile Leu Leu Ile Val Ile Leu Lys Gly Ile Tyr 
    50                  55                  60                  


His Gln Ser Met Ser Gln Ile Tyr Gly Leu Ile His Gly Asp Leu Cys 
65                  70                  75                  80  


Phe Ile Pro Asn Val Tyr Ala Ala Leu Phe Thr Ala Ala Leu Val Pro 
                85                  90                  95      


Leu Thr Cys Leu Val Val Val Phe Val Val Phe Ile His Ala Tyr Gln 
            100                 105                 110         


Val Lys Pro Gln Trp Lys Ala Tyr Asp Asp Val 
        115                 120             


<210>  527
<211>  334
<212>  PRT
<213>  Homo Sapiens

<400>  527

Met Ala Ala Val Thr His Tyr Leu Tyr Leu Cys Gln Phe Ser Trp Met 
1               5                   10                  15      


Leu Ile Gln Ser Val Asn Phe Trp Tyr Val Leu Val Met Asn Asp Glu 
            20                  25                  30          


His Thr Glu Arg Arg Tyr Leu Leu Phe Phe Leu Leu Ser Trp Gly Leu 
        35                  40                  45              


Pro Ala Phe Val Val Ile Leu Leu Ile Val Ile Leu Lys Gly Ile Tyr 
    50                  55                  60                  


His Gln Ser Met Ser Gln Ile Tyr Gly Leu Ile His Gly Asp Leu Cys 
65                  70                  75                  80  


Phe Ile Pro Asn Val Tyr Ala Ala Leu Phe Thr Ala Ala Leu Val Pro 
                85                  90                  95      


Leu Thr Cys Leu Val Val Val Phe Val Val Phe Ile His Ala Tyr Gln 
            100                 105                 110         


Val Lys Pro Gln Trp Lys Ala Tyr Asp Asp Val Phe Arg Gly Arg Thr 
        115                 120                 125             


Asn Ala Ala Glu Ile Pro Leu Ile Leu Tyr Leu Phe Ala Leu Ile Ser 
    130                 135                 140                 


Val Thr Trp Leu Trp Gly Gly Leu His Met Ala Tyr Arg His Phe Trp 
145                 150                 155                 160 


Met Leu Val Leu Phe Val Ile Phe Asn Ser Leu Gln Gly Leu Tyr Val 
                165                 170                 175     


Phe Met Val Tyr Phe Ile Leu His Asn Gln Met Cys Cys Pro Met Lys 
            180                 185                 190         


Ala Ser Tyr Thr Val Glu Met Asn Gly His Pro Gly Pro Ser Thr Ala 
        195                 200                 205             


Phe Phe Thr Pro Gly Ser Gly Met Pro Pro Ala Gly Gly Glu Ile Ser 
    210                 215                 220                 


Lys Ser Thr Gln Asn Leu Ile Gly Ala Met Glu Glu Val Pro Pro Asp 
225                 230                 235                 240 


Trp Glu Arg Ala Ser Phe Gln Gln Gly Ser Gln Ala Ser Pro Asp Leu 
                245                 250                 255     


Lys Pro Ser Pro Gln Asn Gly Ala Thr Phe Pro Ser Ser Gly Gly Tyr 
            260                 265                 270         


Gly Gln Gly Ser Leu Ile Ala Asp Glu Glu Ser Gln Glu Phe Asp Asp 
        275                 280                 285             


Leu Ile Phe Ala Leu Lys Thr Gly Ala Gly Leu Ser Val Ser Asp Asn 
    290                 295                 300                 


Glu Ser Gly Gln Gly Ser Gln Glu Gly Gly Thr Leu Thr Asp Ser Gln 
305                 310                 315                 320 


Ile Val Glu Leu Arg Arg Ile Pro Ile Ala Asp Thr His Leu 
                325                 330                 


<210>  528
<211>  192
<212>  PRT
<213>  Homo Sapiens

<400>  528

Met Ala Ala Val Thr His Tyr Leu Tyr Leu Cys Gln Phe Ser Trp Met 
1               5                   10                  15      


Leu Ile Gln Ser Val Asn Phe Trp Tyr Val Leu Val Met Asn Asp Glu 
            20                  25                  30          


His Thr Glu Arg Arg Tyr Leu Leu Phe Phe Leu Leu Ser Trp Gly Leu 
        35                  40                  45              


Pro Ala Phe Val Val Ile Leu Leu Ile Val Ile Leu Lys Gly Ile Tyr 
    50                  55                  60                  


His Gln Ser Met Ser Gln Ile Tyr Gly Leu Ile His Gly Asp Leu Cys 
65                  70                  75                  80  


Phe Ile Pro Asn Val Tyr Ala Ala Leu Phe Thr Ala Ala Leu Val Pro 
                85                  90                  95      


Leu Thr Cys Leu Val Val Val Phe Val Val Phe Ile His Ala Tyr Gln 
            100                 105                 110         


Val Lys Pro Gln Trp Lys Ala Tyr Asp Asp Val Phe Arg Gly Arg Thr 
        115                 120                 125             


Asn Ala Ala Glu Ile Pro Leu Ile Leu Tyr Leu Phe Ala Leu Ile Ser 
    130                 135                 140                 


Val Thr Trp Leu Trp Gly Gly Leu His Met Ala Tyr Arg His Phe Trp 
145                 150                 155                 160 


Met Leu Val Leu Phe Val Ile Phe Asn Ser Leu Gln Val Leu Val Ser 
                165                 170                 175     


Val Ser Val Ile Met Asn Leu Val Lys Ala Ala Arg Arg Gly Ala Pro 
            180                 185                 190         


<210>  529
<211>  148
<212>  PRT
<213>  Homo Sapiens

<400>  529

Met Ala Lys Arg Ser Ala Ala Ala Ala Val Pro Gly Met Pro Ser Ala 
1               5                   10                  15      


Ser Leu Leu Val Asn Leu Leu Ser Ala Leu Leu Ile Leu Phe Val Phe 
            20                  25                  30          


Gly Glu Thr Glu Ile Arg Phe Thr Gly Gln Thr Glu Phe Val Val Asn 
        35                  40                  45              


Glu Thr Ser Thr Thr Val Ile Arg Leu Ile Ile Glu Arg Ile Gly Glu 
    50                  55                  60                  


Pro Ala Asn Val Thr Ala Ile Val Ser Leu Tyr Gly Glu Asp Ala Gly 
65                  70                  75                  80  


Asp Phe Phe Asp Thr Tyr Ala Ala Ala Phe Ile Pro Ala Gly Glu Thr 
                85                  90                  95      


Asn Arg Thr Val Tyr Ile Ala Val Cys Asp Asp Asp Leu Pro Glu Pro 
            100                 105                 110         


Asp Glu Thr Phe Ile Phe His Leu Thr Leu Gln Leu Pro Ser Ile Ala 
        115                 120                 125             


Val Ser Glu Pro Lys Gly Arg Asn Glu Ser Met Pro Leu Thr Leu Ile 
    130                 135                 140                 


Arg Glu Lys Gly 
145             


<210>  530
<211>  2038
<212>  PRT
<213>  Homo Sapiens

<400>  530

Met Ile Asn Glu Ser Lys Gly Asp Ala Ile Tyr Ser Ala Val Tyr Asp 
1               5                   10                  15      


Val Val Arg Asn Arg Gly Asn Phe Gly Asp Val Ser Val Ser Trp Val 
            20                  25                  30          


Val Ser Pro Asp Phe Thr Gln Asp Val Phe Pro Val Gln Gly Thr Val 
        35                  40                  45              


Val Phe Gly Asp Gln Glu Phe Ser Lys Asn Ile Thr Ile Tyr Ser Leu 
    50                  55                  60                  


Pro Asp Glu Ile Pro Glu Glu Met Glu Glu Phe Thr Val Ile Leu Leu 
65                  70                  75                  80  


Asn Gly Thr Gly Gly Ala Lys Val Gly Asn Arg Thr Thr Ala Thr Leu 
                85                  90                  95      


Arg Ile Arg Arg Asn Asp Asp Pro Ile Tyr Phe Ala Glu Pro Arg Val 
            100                 105                 110         


Val Arg Val Gln Glu Gly Glu Thr Ala Asn Phe Thr Val Leu Arg Asn 
        115                 120                 125             


Gly Ser Val Asp Val Thr Cys Met Val Gln Tyr Ala Thr Lys Asp Gly 
    130                 135                 140                 


Lys Ala Thr Ala Arg Glu Arg Asp Phe Ile Pro Val Glu Lys Gly Glu 
145                 150                 155                 160 


Thr Leu Ile Phe Glu Val Gly Ser Arg Gln Gln Ser Ile Ser Ile Phe 
                165                 170                 175     


Val Asn Glu Asp Gly Ile Pro Glu Thr Asp Glu Pro Phe Tyr Ile Ile 
            180                 185                 190         


Leu Leu Asn Ser Thr Gly Asp Thr Val Val Tyr Gln Tyr Gly Val Ala 
        195                 200                 205             


Thr Val Ile Ile Glu Ala Asn Asp Asp Pro Asn Gly Ile Phe Ser Leu 
    210                 215                 220                 


Glu Pro Ile Asp Lys Ala Val Glu Glu Gly Lys Thr Asn Ala Phe Trp 
225                 230                 235                 240 


Ile Leu Arg His Arg Gly Tyr Phe Gly Ser Val Ser Val Ser Trp Gln 
                245                 250                 255     


Leu Phe Gln Asn Asp Ser Ala Leu Gln Pro Gly Gln Glu Phe Tyr Glu 
            260                 265                 270         


Thr Ser Gly Thr Val Asn Phe Met Asp Gly Glu Glu Ala Lys Pro Ile 
        275                 280                 285             


Ile Leu His Ala Phe Pro Asp Lys Ile Pro Glu Phe Asn Glu Phe Tyr 
    290                 295                 300                 


Phe Leu Lys Leu Val Asn Ile Ser Gly Pro Gly Gly Gln Leu Ala Glu 
305                 310                 315                 320 


Thr Asn Leu Gln Val Thr Val Met Val Pro Phe Asn Asp Asp Pro Phe 
                325                 330                 335     


Gly Val Phe Ile Leu Asp Pro Glu Cys Leu Glu Arg Glu Val Ala Glu 
            340                 345                 350         


Asp Val Leu Ser Glu Asp Asp Met Ser Tyr Ile Thr Asn Phe Thr Ile 
        355                 360                 365             


Leu Arg Gln Gln Gly Val Phe Gly Asp Val Gln Leu Gly Trp Glu Ile 
    370                 375                 380                 


Leu Ser Ser Glu Phe Pro Ala Gly Leu Pro Pro Met Ile Asp Phe Leu 
385                 390                 395                 400 


Leu Val Gly Ile Phe Pro Thr Thr Val His Leu Gln Gln His Met Arg 
                405                 410                 415     


Arg His His Ser Gly Thr Asp Ala Leu Tyr Phe Thr Gly Leu Glu Gly 
            420                 425                 430         


Ala Phe Gly Thr Val Asn Pro Lys Tyr His Pro Ser Arg Asn Asn Thr 
        435                 440                 445             


Ile Ala Asn Phe Thr Phe Ser Ala Trp Val Met Pro Asn Ala Asn Thr 
    450                 455                 460                 


Asn Gly Phe Ile Ile Ala Lys Asp Asp Gly Asn Gly Ser Ile Tyr Tyr 
465                 470                 475                 480 


Gly Val Lys Ile Gln Thr Asn Glu Ser His Val Thr Leu Ser Leu His 
                485                 490                 495     


Tyr Lys Thr Leu Gly Ser Asn Ala Thr Tyr Ile Ala Lys Thr Thr Val 
            500                 505                 510         


Met Lys Tyr Leu Glu Glu Ser Val Trp Leu His Leu Leu Ile Ile Leu 
        515                 520                 525             


Glu Asp Gly Ile Ile Glu Phe Tyr Leu Asp Gly Asn Ala Met Pro Arg 
    530                 535                 540                 


Gly Ile Lys Ser Leu Lys Gly Glu Ala Ile Thr Asp Gly Pro Gly Ile 
545                 550                 555                 560 


Leu Arg Ile Gly Ala Gly Ile Asn Gly Asn Asp Arg Phe Thr Gly Leu 
                565                 570                 575     


Met Gln Asp Val Arg Ser Tyr Glu Arg Lys Leu Thr Leu Glu Glu Ile 
            580                 585                 590         


Tyr Glu Leu His Ala Met Pro Ala Lys Ser Asp Leu His Pro Ile Ser 
        595                 600                 605             


Gly Tyr Leu Glu Phe Arg Gln Gly Glu Thr Asn Lys Ser Phe Ile Ile 
    610                 615                 620                 


Ser Ala Arg Asp Asp Asn Asp Glu Glu Gly Glu Glu Leu Phe Ile Leu 
625                 630                 635                 640 


Lys Leu Val Ser Val Tyr Gly Gly Ala Arg Ile Ser Glu Glu Asn Thr 
                645                 650                 655     


Thr Ala Arg Leu Thr Ile Gln Lys Ser Asp Asn Ala Asn Gly Leu Phe 
            660                 665                 670         


Gly Phe Thr Gly Ala Cys Ile Pro Glu Ile Ala Glu Glu Gly Ser Thr 
        675                 680                 685             


Ile Ser Cys Val Val Glu Arg Thr Arg Gly Ala Leu Asp Tyr Val His 
    690                 695                 700                 


Val Phe Tyr Thr Ile Ser Gln Ile Glu Thr Asp Gly Ile Asn Tyr Leu 
705                 710                 715                 720 


Val Asp Asp Phe Ala Asn Ala Ser Gly Thr Ile Thr Phe Leu Pro Trp 
                725                 730                 735     


Gln Arg Ser Glu Val Leu Asn Ile Tyr Val Leu Asp Asp Asp Ile Pro 
            740                 745                 750         


Glu Leu Asn Glu Tyr Phe Arg Val Thr Leu Val Ser Ala Ile Pro Gly 
        755                 760                 765             


Asp Gly Lys Leu Gly Ser Thr Pro Thr Ser Gly Ala Ser Ile Asp Pro 
    770                 775                 780                 


Glu Lys Glu Thr Thr Asp Ile Thr Ile Lys Ala Ser Asp His Pro Tyr 
785                 790                 795                 800 


Gly Leu Leu Gln Phe Ser Thr Gly Leu Pro Pro Gln Pro Lys Asp Ala 
                805                 810                 815     


Met Thr Leu Pro Ala Ser Ser Val Pro His Ile Thr Val Glu Glu Glu 
            820                 825                 830         


Asp Gly Glu Ile Arg Leu Leu Val Ile Arg Ala Gln Gly Leu Leu Gly 
        835                 840                 845             


Arg Val Thr Ala Glu Phe Arg Thr Val Ser Leu Thr Ala Phe Ser Pro 
    850                 855                 860                 


Glu Asp Tyr Gln Asn Val Ala Gly Thr Leu Glu Phe Gln Pro Gly Glu 
865                 870                 875                 880 


Arg Tyr Lys Tyr Ile Phe Ile Asn Ile Thr Asp Asn Ser Ile Pro Glu 
                885                 890                 895     


Leu Glu Lys Ser Phe Lys Val Glu Leu Leu Asn Leu Glu Gly Gly Val 
            900                 905                 910         


Ala Glu Leu Phe Arg Val Asp Gly Ser Gly Ser Gly Asp Gly Asp Met 
        915                 920                 925             


Glu Phe Phe Leu Pro Thr Ile His Lys Arg Ala Ser Leu Gly Val Ala 
    930                 935                 940                 


Ser Gln Ile Leu Val Thr Ile Ala Ala Ser Asp His Ala His Gly Val 
945                 950                 955                 960 


Phe Glu Phe Ser Pro Glu Ser Leu Phe Val Ser Gly Thr Glu Pro Glu 
                965                 970                 975     


Asp Gly Tyr Ser Thr Val Thr Leu Asn Val Ile Arg His His Gly Thr 
            980                 985                 990         


Leu Ser Pro Val Thr Leu His Trp  Asn Ile Asp Ser Asp  Pro Asp Gly 
        995                 1000                 1005             


Asp Leu  Ala Phe Thr Ser Gly  Asn Ile Thr Phe Glu  Ile Gly Gln 
    1010                 1015                 1020             


Thr Ser  Ala Asn Ile Thr Val  Glu Ile Leu Pro Asp  Glu Asp Pro 
    1025                 1030                 1035             


Glu Leu  Asp Lys Ala Phe Ser  Val Ser Val Leu Ser  Val Ser Ser 
    1040                 1045                 1050             


Gly Ser  Leu Gly Ala His Ile  Asn Ala Thr Leu Thr  Val Leu Ala 
    1055                 1060                 1065             


Ser Asp  Asp Pro Tyr Gly Ile  Phe Ile Phe Ser Glu  Lys Asn Arg 
    1070                 1075                 1080             


Pro Val  Lys Val Glu Glu Ala  Thr Gln Asn Ile Thr  Leu Ser Ile 
    1085                 1090                 1095             


Ile Arg  Leu Lys Gly Leu Met  Gly Lys Val Leu Val  Ser Tyr Ala 
    1100                 1105                 1110             


Thr Leu  Asp Asp Met Glu Lys  Pro Pro Tyr Phe Pro  Pro Asn Leu 
    1115                 1120                 1125             


Ala Arg  Ala Thr Gln Gly Arg  Asp Tyr Ile Pro Ala  Ser Gly Phe 
    1130                 1135                 1140             


Ala Leu  Phe Gly Ala Asn Gln  Ser Glu Ala Thr Ile  Ala Ile Ser 
    1145                 1150                 1155             


Ile Leu  Asp Asp Asp Glu Pro  Glu Arg Ser Glu Ser  Val Phe Ile 
    1160                 1165                 1170             


Glu Leu  Leu Asn Ser Thr Leu  Val Ala Lys Val Gln  Ser Arg Ser 
    1175                 1180                 1185             


Ile Pro  Asn Ser Pro Arg Leu  Gly Pro Lys Val Glu  Thr Ile Ala 
    1190                 1195                 1200             


Gln Leu  Ile Ile Ile Ala Asn  Asp Asp Ala Phe Gly  Thr Leu Gln 
    1205                 1210                 1215             


Leu Ser  Ala Pro Ile Val Arg  Val Ala Glu Asn His  Val Gly Pro 
    1220                 1225                 1230             


Ile Ile  Asn Val Thr Arg Thr  Gly Gly Ala Phe Ala  Asp Val Ser 
    1235                 1240                 1245             


Val Lys  Phe Lys Ala Val Pro  Ile Thr Ala Ile Ala  Gly Glu Asp 
    1250                 1255                 1260             


Tyr Ser  Ile Ala Ser Ser Asp  Val Val Leu Leu Glu  Gly Glu Thr 
    1265                 1270                 1275             


Ser Lys  Ala Val Pro Ile Tyr  Val Ile Asn Asp Ile  Tyr Pro Glu 
    1280                 1285                 1290             


Leu Glu  Glu Ser Phe Leu Val  Gln Leu Met Asn Glu  Thr Thr Gly 
    1295                 1300                 1305             


Gly Ala  Arg Leu Gly Ala Leu  Thr Glu Ala Val Ile  Ile Ile Glu 
    1310                 1315                 1320             


Ala Ser  Asp Asp Pro Tyr Gly  Leu Phe Gly Phe Gln  Ile Thr Lys 
    1325                 1330                 1335             


Leu Ile  Val Glu Glu Pro Glu  Phe Asn Ser Val Lys  Val Asn Leu 
    1340                 1345                 1350             


Pro Ile  Ile Arg Asn Ser Gly  Thr Leu Gly Asn Val  Thr Val Gln 
    1355                 1360                 1365             


Trp Val  Ala Thr Ile Asn Gly  Gln Leu Ala Thr Gly  Asp Leu Arg 
    1370                 1375                 1380             


Val Val  Ser Gly Asn Val Thr  Phe Ala Pro Gly Glu  Thr Ile Gln 
    1385                 1390                 1395             


Thr Leu  Leu Leu Glu Val Leu  Ala Asp Asp Val Pro  Glu Ile Glu 
    1400                 1405                 1410             


Glu Val  Ile Gln Val Gln Leu  Thr Asp Ala Ser Gly  Gly Gly Thr 
    1415                 1420                 1425             


Ile Gly  Leu Asp Arg Ile Ala  Asn Ile Ile Ile Pro  Ala Asn Asp 
    1430                 1435                 1440             


Asp Pro  Tyr Gly Thr Val Ala  Phe Ala Gln Met Val  Tyr Arg Val 
    1445                 1450                 1455             


Gln Glu  Pro Leu Glu Arg Ser  Ser Cys Ala Asn Ile  Thr Val Arg 
    1460                 1465                 1470             


Arg Ser  Gly Gly His Phe Gly  Arg Leu Leu Leu Phe  Tyr Ser Thr 
    1475                 1480                 1485             


Ser Asp  Ile Asp Val Val Ala  Leu Ala Met Glu Glu  Gly Gln Asp 
    1490                 1495                 1500             


Leu Leu  Ser Tyr Tyr Glu Ser  Pro Ile Gln Gly Val  Pro Asp Pro 
    1505                 1510                 1515             


Leu Trp  Arg Thr Trp Met Asn  Val Ser Ala Val Gly  Glu Pro Leu 
    1520                 1525                 1530             


Tyr Thr  Cys Ala Thr Leu Cys  Leu Lys Glu Gln Ala  Cys Ser Ala 
    1535                 1540                 1545             


Phe Ser  Phe Phe Ser Ala Ser  Glu Gly Pro Gln Cys  Phe Trp Met 
    1550                 1555                 1560             


Thr Ser  Trp Ile Ser Pro Ala  Val Asn Asn Ser Asp  Phe Trp Thr 
    1565                 1570                 1575             


Tyr Arg  Lys Asn Met Thr Arg  Val Ala Ser Leu Phe  Ser Gly Gln 
    1580                 1585                 1590             


Ala Val  Ala Gly Ser Asp Tyr  Glu Pro Val Thr Arg  Gln Trp Ala 
    1595                 1600                 1605             


Ile Met  Gln Glu Gly Asp Glu  Phe Ala Asn Leu Thr  Val Ser Ile 
    1610                 1615                 1620             


Leu Pro  Asp Asp Phe Pro Glu  Met Asp Glu Ser Phe  Leu Ile Ser 
    1625                 1630                 1635             


Leu Leu  Glu Val His Leu Met  Asn Ile Ser Ala Ser  Leu Lys Asn 
    1640                 1645                 1650             


Gln Pro  Thr Ile Gly Gln Pro  Asn Ile Ser Thr Val  Val Ile Ala 
    1655                 1660                 1665             


Leu Asn  Gly Asp Ala Phe Gly  Val Phe Val Ile Tyr  Asn Ile Ser 
    1670                 1675                 1680             


Pro Asn  Thr Ser Glu Asp Gly  Leu Phe Val Glu Val  Gln Glu Gln 
    1685                 1690                 1695             


Pro Gln  Thr Leu Val Glu Leu  Met Ile His Arg Thr  Gly Gly Ser 
    1700                 1705                 1710             


Leu Gly  Gln Val Ala Val Glu  Trp Arg Val Val Gly  Gly Thr Ala 
    1715                 1720                 1725             


Thr Glu  Gly Leu Asp Phe Ile  Gly Ala Gly Glu Ile  Leu Thr Phe 
    1730                 1735                 1740             


Ala Glu  Gly Glu Thr Lys Lys  Thr Val Ile Leu Thr  Ile Leu Asp 
    1745                 1750                 1755             


Asp Ser  Glu Pro Glu Asp Asp  Glu Ser Ile Ile Val  Ser Leu Val 
    1760                 1765                 1770             


Tyr Thr  Glu Gly Gly Ser Arg  Ile Leu Pro Ser Ser  Asp Thr Val 
    1775                 1780                 1785             


Arg Val  Asn Ile Leu Ala Asn  Asp Asn Val Ala Gly  Ile Val Ser 
    1790                 1795                 1800             


Phe Gln  Thr Ala Ser Arg Ser  Val Ile Gly His Glu  Gly Glu Ile 
    1805                 1810                 1815             


Leu Gln  Phe His Val Ile Arg  Thr Phe Pro Gly Arg  Gly Asn Val 
    1820                 1825                 1830             


Thr Val  Asn Trp Lys Ile Ile  Gly Gln Asn Leu Glu  Leu Asn Phe 
    1835                 1840                 1845             


Ala Asn  Phe Ser Gly Gln Leu  Phe Phe Pro Glu Gly  Ser Leu Asn 
    1850                 1855                 1860             


Thr Thr  Leu Phe Val His Leu  Leu Asp Asp Asn Ile  Pro Glu Glu 
    1865                 1870                 1875             


Lys Glu  Val Tyr Gln Val Ile  Leu Tyr Asp Val Arg  Thr Gln Gly 
    1880                 1885                 1890             


Val Pro  Pro Ala Gly Ile Ala  Leu Leu Asp Ala Gln  Gly Tyr Ala 
    1895                 1900                 1905             


Ala Val  Leu Thr Val Glu Ala  Ser Asp Glu Pro His  Gly Val Leu 
    1910                 1915                 1920             


Asn Phe  Ala Leu Ser Ser Arg  Phe Val Leu Leu Gln  Glu Ala Asn 
    1925                 1930                 1935             


Ile Thr  Ile Gln Leu Phe Ile  Asn Arg Glu Phe Gly  Ser Leu Gly 
    1940                 1945                 1950             


Ala Ile  Asn Val Thr Tyr Thr  Thr Val Pro Gly Met  Leu Ser Leu 
    1955                 1960                 1965             


Lys Asn  Gln Thr Val Gly Asn  Leu Ala Glu Pro Glu  Val Asp Phe 
    1970                 1975                 1980             


Val Pro  Ile Ile Gly Phe Leu  Ile Leu Glu Glu Gly  Glu Thr Ala 
    1985                 1990                 1995             


Ala Ala  Ile Asn Ile Thr Ile  Leu Glu Asp Asp Val  Pro Glu Leu 
    2000                 2005                 2010             


Glu Glu  Tyr Phe Leu Val Asn  Leu Thr Tyr Val Gly  Leu Thr Met 
    2015                 2020                 2025             


Ala Ala  Ser Thr Ser Phe Pro  Pro Arg Leu 
    2030                 2035             


<210>  531
<211>  6306
<212>  PRT
<213>  Homo Sapiens

<400>  531

Met Ser Val Phe Leu Gly Pro Gly Met Pro Ser Ala Ser Leu Leu Val 
1               5                   10                  15      


Asn Leu Leu Ser Ala Leu Leu Ile Leu Phe Val Phe Gly Glu Thr Glu 
            20                  25                  30          


Ile Arg Phe Thr Gly Gln Thr Glu Phe Val Val Asn Glu Thr Ser Thr 
        35                  40                  45              


Thr Val Ile Arg Leu Ile Ile Glu Arg Ile Gly Glu Pro Ala Asn Val 
    50                  55                  60                  


Thr Ala Ile Val Ser Leu Tyr Gly Glu Asp Ala Gly Asp Phe Phe Asp 
65                  70                  75                  80  


Thr Tyr Ala Ala Ala Phe Ile Pro Ala Gly Glu Thr Asn Arg Thr Val 
                85                  90                  95      


Tyr Ile Ala Val Cys Asp Asp Asp Leu Pro Glu Pro Asp Glu Thr Phe 
            100                 105                 110         


Ile Phe His Leu Thr Leu Gln Lys Pro Ser Ala Asn Val Lys Leu Gly 
        115                 120                 125             


Trp Pro Arg Thr Val Thr Val Thr Ile Leu Ser Asn Asp Asn Ala Phe 
    130                 135                 140                 


Gly Ile Ile Ser Phe Asn Met Leu Pro Ser Ile Ala Val Ser Glu Pro 
145                 150                 155                 160 


Lys Gly Arg Asn Glu Ser Met Pro Leu Thr Leu Ile Arg Glu Lys Gly 
                165                 170                 175     


Thr Tyr Gly Met Val Met Val Thr Phe Glu Val Glu Gly Gly Pro Asn 
            180                 185                 190         


Pro Pro Asp Glu Asp Leu Ser Pro Val Lys Gly Asn Ile Thr Phe Pro 
        195                 200                 205             


Pro Gly Arg Ala Thr Val Ile Tyr Asn Leu Thr Val Leu Asp Asp Glu 
    210                 215                 220                 


Val Pro Glu Asn Asp Glu Ile Phe Leu Ile Gln Leu Lys Ser Val Glu 
225                 230                 235                 240 


Gly Gly Ala Glu Ile Asn Thr Ser Arg Asn Ser Ile Glu Ile Ile Ile 
                245                 250                 255     


Lys Lys Asn Asp Ser Pro Val Arg Phe Leu Gln Ser Ile Tyr Leu Val 
            260                 265                 270         


Pro Glu Glu Asp His Ile Leu Ile Ile Pro Val Val Arg Gly Lys Asp 
        275                 280                 285             


Asn Asn Gly Asn Leu Ile Gly Ser Asp Glu Tyr Glu Val Ser Ile Ser 
    290                 295                 300                 


Tyr Ala Val Thr Thr Gly Asn Ser Thr Ala His Ala Gln Gln Asn Leu 
305                 310                 315                 320 


Asp Phe Ile Asp Leu Gln Pro Asn Thr Thr Val Val Phe Pro Pro Phe 
                325                 330                 335     


Ile His Glu Ser His Leu Lys Phe Gln Ile Val Asp Asp Thr Ile Pro 
            340                 345                 350         


Glu Ile Ala Glu Ser Phe His Ile Met Leu Leu Lys Asp Thr Leu Gln 
        355                 360                 365             


Gly Asp Ala Val Leu Ile Ser Pro Ser Val Val Gln Val Thr Ile Lys 
    370                 375                 380                 


Pro Asn Asp Lys Pro Tyr Gly Val Leu Ser Phe Asn Ser Val Leu Phe 
385                 390                 395                 400 


Glu Arg Thr Val Ile Ile Asp Glu Asp Arg Ile Ser Arg Tyr Glu Glu 
                405                 410                 415     


Ile Thr Val Val Arg Asn Gly Gly Thr His Gly Asn Val Ser Ala Asn 
            420                 425                 430         


Trp Val Leu Thr Arg Asn Ser Thr Asp Pro Ser Pro Val Thr Ala Asp 
        435                 440                 445             


Ile Arg Pro Ser Ser Gly Val Leu His Phe Ala Gln Gly Gln Met Leu 
    450                 455                 460                 


Ala Thr Ile Pro Leu Thr Val Val Asp Asp Asp Leu Pro Glu Glu Ala 
465                 470                 475                 480 


Glu Ala Tyr Leu Leu Gln Ile Leu Pro His Thr Ile Arg Gly Gly Ala 
                485                 490                 495     


Glu Val Ser Glu Pro Ala Glu Leu Leu Phe Tyr Ile Gln Asp Ser Asp 
            500                 505                 510         


Asp Val Tyr Gly Leu Ile Thr Phe Phe Pro Met Glu Asn Gln Lys Ile 
        515                 520                 525             


Glu Ser Ser Pro Gly Glu Arg Tyr Leu Ser Leu Ser Phe Thr Arg Leu 
    530                 535                 540                 


Gly Gly Thr Lys Gly Asp Val Arg Leu Leu Tyr Ser Val Leu Tyr Ile 
545                 550                 555                 560 


Pro Ala Gly Ala Val Asp Pro Leu Gln Ala Lys Glu Gly Ile Leu Asn 
                565                 570                 575     


Ile Ser Arg Arg Asn Asp Leu Ile Phe Pro Glu Gln Lys Thr Gln Val 
            580                 585                 590         


Thr Thr Lys Leu Pro Ile Arg Asn Asp Ala Phe Leu Gln Asn Gly Ala 
        595                 600                 605             


His Phe Leu Val Gln Leu Glu Thr Val Glu Leu Leu Asn Ile Ile Pro 
    610                 615                 620                 


Leu Ile Pro Pro Ile Ser Pro Arg Phe Gly Glu Ile Cys Asn Ile Ser 
625                 630                 635                 640 


Leu Leu Val Thr Pro Ala Ile Ala Asn Gly Glu Ile Gly Phe Leu Ser 
                645                 650                 655     


Asn Leu Pro Ile Ile Leu His Glu Pro Glu Asp Phe Ala Ala Glu Val 
            660                 665                 670         


Val Tyr Ile Pro Leu His Arg Asp Gly Thr Asp Gly Gln Ala Thr Val 
        675                 680                 685             


Tyr Trp Ser Leu Lys Pro Ser Gly Phe Asn Ser Lys Ala Val Thr Pro 
    690                 695                 700                 


Asp Asp Ile Gly Pro Phe Asn Gly Ser Val Leu Phe Leu Ser Gly Gln 
705                 710                 715                 720 


Ser Asp Thr Thr Ile Asn Ile Thr Ile Lys Gly Asp Asp Ile Pro Glu 
                725                 730                 735     


Met Asn Glu Thr Val Thr Leu Ser Leu Asp Arg Val Asn Val Glu Asn 
            740                 745                 750         


Gln Val Leu Lys Ser Gly Tyr Thr Ser Arg Asp Leu Ile Ile Leu Glu 
        755                 760                 765             


Asn Asp Asp Pro Gly Gly Val Phe Glu Phe Ser Pro Ala Ser Arg Gly 
    770                 775                 780                 


Pro Tyr Val Ile Lys Glu Gly Glu Ser Val Glu Leu His Ile Ile Arg 
785                 790                 795                 800 


Ser Arg Gly Ser Leu Val Lys Gln Phe Leu His Tyr Arg Val Glu Pro 
                805                 810                 815     


Arg Asp Ser Asn Glu Phe Tyr Gly Asn Thr Gly Val Leu Glu Phe Lys 
            820                 825                 830         


Pro Gly Glu Arg Glu Ile Val Ile Thr Leu Leu Ala Arg Leu Asp Gly 
        835                 840                 845             


Ile Pro Glu Leu Asp Glu His Tyr Trp Val Val Leu Ser Ser His Gly 
    850                 855                 860                 


Glu Arg Glu Ser Lys Leu Gly Ser Ala Thr Ile Val Asn Ile Thr Ile 
865                 870                 875                 880 


Leu Lys Asn Asp Asp Pro His Gly Ile Ile Glu Phe Val Ser Asp Gly 
                885                 890                 895     


Leu Ile Val Met Ile Asn Glu Ser Lys Gly Asp Ala Ile Tyr Ser Ala 
            900                 905                 910         


Val Tyr Asp Val Val Arg Asn Arg Gly Asn Phe Gly Asp Val Ser Val 
        915                 920                 925             


Ser Trp Val Val Ser Pro Asp Phe Thr Gln Asp Val Phe Pro Val Gln 
    930                 935                 940                 


Gly Thr Val Val Phe Gly Asp Gln Glu Phe Ser Lys Asn Ile Thr Ile 
945                 950                 955                 960 


Tyr Ser Leu Pro Asp Glu Ile Pro Glu Glu Met Glu Glu Phe Thr Val 
                965                 970                 975     


Ile Leu Leu Asn Gly Thr Gly Gly Ala Lys Val Gly Asn Arg Thr Thr 
            980                 985                 990         


Ala Thr Leu Arg Ile Arg Arg Asn  Asp Asp Pro Ile Tyr  Phe Ala Glu 
        995                 1000                 1005             


Pro Arg  Val Val Arg Val Gln  Glu Gly Glu Thr Ala  Asn Phe Thr 
    1010                 1015                 1020             


Val Leu  Arg Asn Gly Ser Val  Asp Val Thr Cys Met  Val Gln Tyr 
    1025                 1030                 1035             


Ala Thr  Lys Asp Gly Lys Ala  Thr Ala Arg Glu Arg  Asp Phe Ile 
    1040                 1045                 1050             


Pro Val  Glu Lys Gly Glu Thr  Leu Ile Phe Glu Val  Gly Ser Arg 
    1055                 1060                 1065             


Gln Gln  Ser Ile Ser Ile Phe  Val Asn Glu Asp Gly  Ile Pro Glu 
    1070                 1075                 1080             


Thr Asp  Glu Pro Phe Tyr Ile  Ile Leu Leu Asn Ser  Thr Gly Asp 
    1085                 1090                 1095             


Thr Val  Val Tyr Gln Tyr Gly  Val Ala Thr Val Ile  Ile Glu Ala 
    1100                 1105                 1110             


Asn Asp  Asp Pro Asn Gly Ile  Phe Ser Leu Glu Pro  Ile Asp Lys 
    1115                 1120                 1125             


Ala Val  Glu Glu Gly Lys Thr  Asn Ala Phe Trp Ile  Leu Arg His 
    1130                 1135                 1140             


Arg Gly  Tyr Phe Gly Ser Val  Ser Val Ser Trp Gln  Leu Phe Gln 
    1145                 1150                 1155             


Asn Asp  Ser Ala Leu Gln Pro  Gly Gln Glu Phe Tyr  Glu Thr Ser 
    1160                 1165                 1170             


Gly Thr  Val Asn Phe Met Asp  Gly Glu Glu Ala Lys  Pro Ile Ile 
    1175                 1180                 1185             


Leu His  Ala Phe Pro Asp Lys  Ile Pro Glu Phe Asn  Glu Phe Tyr 
    1190                 1195                 1200             


Phe Leu  Lys Leu Val Asn Ile  Ser Gly Gly Ser Pro  Gly Pro Gly 
    1205                 1210                 1215             


Gly Gln  Leu Ala Glu Thr Asn  Leu Gln Val Thr Val  Met Val Pro 
    1220                 1225                 1230             


Phe Asn  Asp Asp Pro Phe Gly  Val Phe Ile Leu Asp  Pro Glu Cys 
    1235                 1240                 1245             


Leu Glu  Arg Glu Val Ala Glu  Asp Val Leu Ser Glu  Asp Asp Met 
    1250                 1255                 1260             


Ser Tyr  Ile Thr Asn Phe Thr  Ile Leu Arg Gln Gln  Gly Val Phe 
    1265                 1270                 1275             


Gly Asp  Val Gln Leu Gly Trp  Glu Ile Leu Ser Ser  Glu Phe Pro 
    1280                 1285                 1290             


Ala Gly  Leu Pro Pro Met Ile  Asp Phe Leu Leu Val  Gly Ile Phe 
    1295                 1300                 1305             


Pro Thr  Thr Val His Leu Gln  Gln His Met Arg Arg  His His Ser 
    1310                 1315                 1320             


Gly Thr  Asp Ala Leu Tyr Phe  Thr Gly Leu Glu Gly  Ala Phe Gly 
    1325                 1330                 1335             


Thr Val  Asn Pro Lys Tyr His  Pro Ser Arg Asn Asn  Thr Ile Ala 
    1340                 1345                 1350             


Asn Phe  Thr Phe Ser Ala Trp  Val Met Pro Asn Ala  Asn Thr Asn 
    1355                 1360                 1365             


Gly Phe  Ile Ile Ala Lys Asp  Asp Gly Asn Gly Ser  Ile Tyr Tyr 
    1370                 1375                 1380             


Gly Val  Lys Ile Gln Thr Asn  Glu Ser His Val Thr  Leu Ser Leu 
    1385                 1390                 1395             


His Tyr  Lys Thr Leu Gly Ser  Asn Ala Thr Tyr Ile  Ala Lys Thr 
    1400                 1405                 1410             


Thr Val  Met Lys Tyr Leu Glu  Glu Ser Val Trp Leu  His Leu Leu 
    1415                 1420                 1425             


Ile Ile  Leu Glu Asp Gly Ile  Ile Glu Phe Tyr Leu  Asp Gly Asn 
    1430                 1435                 1440             


Ala Met  Pro Arg Gly Ile Lys  Ser Leu Lys Gly Glu  Ala Ile Thr 
    1445                 1450                 1455             


Asp Gly  Pro Gly Ile Leu Arg  Ile Gly Ala Gly Ile  Asn Gly Asn 
    1460                 1465                 1470             


Asp Arg  Phe Thr Gly Leu Met  Gln Asp Val Arg Ser  Tyr Glu Arg 
    1475                 1480                 1485             


Lys Leu  Thr Leu Glu Glu Ile  Tyr Glu Leu His Ala  Met Pro Ala 
    1490                 1495                 1500             


Lys Ser  Asp Leu His Pro Ile  Ser Gly Tyr Leu Glu  Phe Arg Gln 
    1505                 1510                 1515             


Gly Glu  Thr Asn Lys Ser Phe  Ile Ile Ser Ala Arg  Asp Asp Asn 
    1520                 1525                 1530             


Asp Glu  Glu Gly Glu Glu Leu  Phe Ile Leu Lys Leu  Val Ser Val 
    1535                 1540                 1545             


Tyr Gly  Gly Ala Arg Ile Ser  Glu Glu Asn Thr Thr  Ala Arg Leu 
    1550                 1555                 1560             


Thr Ile  Gln Lys Ser Asp Asn  Ala Asn Gly Leu Phe  Gly Phe Thr 
    1565                 1570                 1575             


Gly Ala  Cys Ile Pro Glu Ile  Ala Glu Glu Gly Ser  Thr Ile Ser 
    1580                 1585                 1590             


Cys Val  Val Glu Arg Thr Arg  Gly Ala Leu Asp Tyr  Val His Val 
    1595                 1600                 1605             


Phe Tyr  Thr Ile Ser Gln Ile  Glu Thr Asp Gly Ile  Asn Tyr Leu 
    1610                 1615                 1620             


Val Asp  Asp Phe Ala Asn Ala  Ser Gly Thr Ile Thr  Phe Leu Pro 
    1625                 1630                 1635             


Trp Gln  Arg Ser Glu Val Leu  Asn Ile Tyr Val Leu  Asp Asp Asp 
    1640                 1645                 1650             


Ile Pro  Glu Leu Asn Glu Tyr  Phe Arg Val Thr Leu  Val Ser Ala 
    1655                 1660                 1665             


Ile Pro  Gly Asp Gly Lys Leu  Gly Ser Thr Pro Thr  Ser Gly Ala 
    1670                 1675                 1680             


Ser Ile  Asp Pro Glu Lys Glu  Thr Thr Asp Ile Thr  Ile Lys Ala 
    1685                 1690                 1695             


Ser Asp  His Pro Tyr Gly Leu  Leu Gln Phe Ser Thr  Gly Leu Pro 
    1700                 1705                 1710             


Pro Gln  Pro Lys Asp Ala Met  Thr Leu Pro Ala Ser  Ser Val Pro 
    1715                 1720                 1725             


His Ile  Thr Val Glu Glu Glu  Asp Gly Glu Ile Arg  Leu Leu Val 
    1730                 1735                 1740             


Ile Arg  Ala Gln Gly Leu Leu  Gly Arg Val Thr Ala  Glu Phe Arg 
    1745                 1750                 1755             


Thr Val  Ser Leu Thr Ala Phe  Ser Pro Glu Asp Tyr  Gln Asn Val 
    1760                 1765                 1770             


Ala Gly  Thr Leu Glu Phe Gln  Pro Gly Glu Arg Tyr  Lys Tyr Ile 
    1775                 1780                 1785             


Phe Ile  Asn Ile Thr Asp Asn  Ser Ile Pro Glu Leu  Glu Lys Ser 
    1790                 1795                 1800             


Phe Lys  Val Glu Leu Leu Asn  Leu Glu Gly Gly Val  Ala Glu Leu 
    1805                 1810                 1815             


Phe Arg  Val Asp Gly Ser Gly  Ser Gly Asp Gly Asp  Met Glu Phe 
    1820                 1825                 1830             


Phe Leu  Pro Thr Ile His Lys  Arg Ala Ser Leu Gly  Val Ala Ser 
    1835                 1840                 1845             


Gln Ile  Leu Val Thr Ile Ala  Ala Ser Asp His Ala  His Gly Val 
    1850                 1855                 1860             


Phe Glu  Phe Ser Pro Glu Ser  Leu Phe Val Ser Gly  Thr Glu Pro 
    1865                 1870                 1875             


Glu Asp  Gly Tyr Ser Thr Val  Thr Leu Asn Val Ile  Arg His His 
    1880                 1885                 1890             


Gly Thr  Leu Ser Pro Val Thr  Leu His Trp Asn Ile  Asp Ser Asp 
    1895                 1900                 1905             


Pro Asp  Gly Asp Leu Ala Phe  Thr Ser Gly Asn Ile  Thr Phe Glu 
    1910                 1915                 1920             


Ile Gly  Gln Thr Ser Ala Asn  Ile Thr Val Glu Ile  Leu Pro Asp 
    1925                 1930                 1935             


Glu Asp  Pro Glu Leu Asp Lys  Ala Phe Ser Val Ser  Val Leu Ser 
    1940                 1945                 1950             


Val Ser  Ser Gly Ser Leu Gly  Ala His Ile Asn Ala  Thr Leu Thr 
    1955                 1960                 1965             


Val Leu  Ala Ser Asp Asp Pro  Tyr Gly Ile Phe Ile  Phe Ser Glu 
    1970                 1975                 1980             


Lys Asn  Arg Pro Val Lys Val  Glu Glu Ala Thr Gln  Asn Ile Thr 
    1985                 1990                 1995             


Leu Ser  Ile Ile Arg Leu Lys  Gly Leu Met Gly Lys  Val Leu Val 
    2000                 2005                 2010             


Ser Tyr  Ala Thr Leu Asp Asp  Met Glu Lys Pro Pro  Tyr Phe Pro 
    2015                 2020                 2025             


Pro Asn  Leu Ala Arg Ala Thr  Gln Gly Arg Asp Tyr  Ile Pro Ala 
    2030                 2035                 2040             


Ser Gly  Phe Ala Leu Phe Gly  Ala Asn Gln Ser Glu  Ala Thr Ile 
    2045                 2050                 2055             


Ala Ile  Ser Ile Leu Asp Asp  Asp Glu Pro Glu Arg  Ser Glu Ser 
    2060                 2065                 2070             


Val Phe  Ile Glu Leu Leu Asn  Ser Thr Leu Val Ala  Lys Val Gln 
    2075                 2080                 2085             


Ser Arg  Ser Ile Pro Asn Ser  Pro Arg Leu Gly Pro  Lys Val Glu 
    2090                 2095                 2100             


Thr Ile  Ala Gln Leu Ile Ile  Ile Ala Asn Asp Asp  Ala Phe Gly 
    2105                 2110                 2115             


Thr Leu  Gln Leu Ser Ala Pro  Ile Val Arg Val Ala  Glu Asn His 
    2120                 2125                 2130             


Val Gly  Pro Ile Ile Asn Val  Thr Arg Thr Gly Gly  Ala Phe Ala 
    2135                 2140                 2145             


Asp Val  Ser Val Lys Phe Lys  Ala Val Pro Ile Thr  Ala Ile Ala 
    2150                 2155                 2160             


Gly Glu  Asp Tyr Ser Ile Ala  Ser Ser Asp Val Val  Leu Leu Glu 
    2165                 2170                 2175             


Gly Glu  Thr Ser Lys Ala Val  Pro Ile Tyr Val Ile  Asn Asp Ile 
    2180                 2185                 2190             


Tyr Pro  Glu Leu Glu Glu Ser  Phe Leu Val Gln Leu  Met Asn Glu 
    2195                 2200                 2205             


Thr Thr  Gly Gly Ala Arg Leu  Gly Ala Leu Thr Glu  Ala Val Ile 
    2210                 2215                 2220             


Ile Ile  Glu Ala Ser Asp Asp  Pro Tyr Gly Leu Phe  Gly Phe Gln 
    2225                 2230                 2235             


Ile Thr  Lys Leu Ile Val Glu  Glu Pro Glu Phe Asn  Ser Val Lys 
    2240                 2245                 2250             


Val Asn  Leu Pro Ile Ile Arg  Asn Ser Gly Thr Leu  Gly Asn Val 
    2255                 2260                 2265             


Thr Val  Gln Trp Val Ala Thr  Ile Asn Gly Gln Leu  Ala Thr Gly 
    2270                 2275                 2280             


Asp Leu  Arg Val Val Ser Gly  Asn Val Thr Phe Ala  Pro Gly Glu 
    2285                 2290                 2295             


Thr Ile  Gln Thr Leu Leu Leu  Glu Val Leu Ala Asp  Asp Val Pro 
    2300                 2305                 2310             


Glu Ile  Glu Glu Val Ile Gln  Val Gln Leu Thr Asp  Ala Ser Gly 
    2315                 2320                 2325             


Gly Gly  Thr Ile Gly Leu Asp  Arg Ile Ala Asn Ile  Ile Ile Pro 
    2330                 2335                 2340             


Ala Asn  Asp Asp Pro Tyr Gly  Thr Val Ala Phe Ala  Gln Met Val 
    2345                 2350                 2355             


Tyr Arg  Val Gln Glu Pro Leu  Glu Arg Ser Ser Cys  Ala Asn Ile 
    2360                 2365                 2370             


Thr Val  Arg Arg Ser Gly Gly  His Phe Gly Arg Leu  Leu Leu Phe 
    2375                 2380                 2385             


Tyr Ser  Thr Ser Asp Ile Asp  Val Val Ala Leu Ala  Met Glu Glu 
    2390                 2395                 2400             


Gly Gln  Asp Leu Leu Ser Tyr  Tyr Glu Ser Pro Ile  Gln Gly Val 
    2405                 2410                 2415             


Pro Asp  Pro Leu Trp Arg Thr  Trp Met Asn Val Ser  Ala Val Gly 
    2420                 2425                 2430             


Glu Pro  Leu Tyr Thr Cys Ala  Thr Leu Cys Leu Lys  Glu Gln Ala 
    2435                 2440                 2445             


Cys Ser  Ala Phe Ser Phe Phe  Ser Ala Ser Glu Gly  Pro Gln Cys 
    2450                 2455                 2460             


Phe Trp  Met Thr Ser Trp Ile  Ser Pro Ala Val Asn  Asn Ser Asp 
    2465                 2470                 2475             


Phe Trp  Thr Tyr Arg Lys Asn  Met Thr Arg Val Ala  Ser Leu Phe 
    2480                 2485                 2490             


Ser Gly  Gln Ala Val Ala Gly  Ser Asp Tyr Glu Pro  Val Thr Arg 
    2495                 2500                 2505             


Gln Trp  Ala Ile Met Gln Glu  Gly Asp Glu Phe Ala  Asn Leu Thr 
    2510                 2515                 2520             


Val Ser  Ile Leu Pro Asp Asp  Phe Pro Glu Met Asp  Glu Ser Phe 
    2525                 2530                 2535             


Leu Ile  Ser Leu Leu Glu Val  His Leu Met Asn Ile  Ser Ala Ser 
    2540                 2545                 2550             


Leu Lys  Asn Gln Pro Thr Ile  Gly Gln Pro Asn Ile  Ser Thr Val 
    2555                 2560                 2565             


Val Ile  Ala Leu Asn Gly Asp  Ala Phe Gly Val Phe  Val Ile Tyr 
    2570                 2575                 2580             


Asn Ile  Ser Pro Asn Thr Ser  Glu Asp Gly Leu Phe  Val Glu Val 
    2585                 2590                 2595             


Gln Glu  Gln Pro Gln Thr Leu  Val Glu Leu Met Ile  His Arg Thr 
    2600                 2605                 2610             


Gly Gly  Ser Leu Gly Gln Val  Ala Val Glu Trp Arg  Val Val Gly 
    2615                 2620                 2625             


Gly Thr  Ala Thr Glu Gly Leu  Asp Phe Ile Gly Ala  Gly Glu Ile 
    2630                 2635                 2640             


Leu Thr  Phe Ala Glu Gly Glu  Thr Lys Lys Thr Val  Ile Leu Thr 
    2645                 2650                 2655             


Ile Leu  Asp Asp Ser Glu Pro  Glu Asp Asp Glu Ser  Ile Ile Val 
    2660                 2665                 2670             


Ser Leu  Val Tyr Thr Glu Gly  Gly Ser Arg Ile Leu  Pro Ser Ser 
    2675                 2680                 2685             


Asp Thr  Val Arg Val Asn Ile  Leu Ala Asn Asp Asn  Val Ala Gly 
    2690                 2695                 2700             


Ile Val  Ser Phe Gln Thr Ala  Ser Arg Ser Val Ile  Gly His Glu 
    2705                 2710                 2715             


Gly Glu  Ile Leu Gln Phe His  Val Ile Arg Thr Phe  Pro Gly Arg 
    2720                 2725                 2730             


Gly Asn  Val Thr Val Asn Trp  Lys Ile Ile Gly Gln  Asn Leu Glu 
    2735                 2740                 2745             


Leu Asn  Phe Ala Asn Phe Ser  Gly Gln Leu Phe Phe  Pro Glu Gly 
    2750                 2755                 2760             


Ser Leu  Asn Thr Thr Leu Phe  Val His Leu Leu Asp  Asp Asn Ile 
    2765                 2770                 2775             


Pro Glu  Glu Lys Glu Val Tyr  Gln Val Ile Leu Tyr  Asp Val Arg 
    2780                 2785                 2790             


Thr Gln  Gly Val Pro Pro Ala  Gly Ile Ala Leu Leu  Asp Ala Gln 
    2795                 2800                 2805             


Gly Tyr  Ala Ala Val Leu Thr  Val Glu Ala Ser Asp  Glu Pro His 
    2810                 2815                 2820             


Gly Val  Leu Asn Phe Ala Leu  Ser Ser Arg Phe Val  Leu Leu Gln 
    2825                 2830                 2835             


Glu Ala  Asn Ile Thr Ile Gln  Leu Phe Ile Asn Arg  Glu Phe Gly 
    2840                 2845                 2850             


Ser Leu  Gly Ala Ile Asn Val  Thr Tyr Thr Thr Val  Pro Gly Met 
    2855                 2860                 2865             


Leu Ser  Leu Lys Asn Gln Thr  Val Gly Asn Leu Ala  Glu Pro Glu 
    2870                 2875                 2880             


Val Asp  Phe Val Pro Ile Ile  Gly Phe Leu Ile Leu  Glu Glu Gly 
    2885                 2890                 2895             


Glu Thr  Ala Ala Ala Ile Asn  Ile Thr Ile Leu Glu  Asp Asp Val 
    2900                 2905                 2910             


Pro Glu  Leu Glu Glu Tyr Phe  Leu Val Asn Leu Thr  Tyr Val Gly 
    2915                 2920                 2925             


Leu Thr  Met Ala Ala Ser Thr  Ser Phe Pro Pro Arg  Leu Asp Ser 
    2930                 2935                 2940             


Glu Gly  Leu Thr Ala Gln Val  Ile Ile Asp Ala Asn  Asp Gly Ala 
    2945                 2950                 2955             


Arg Gly  Val Ile Glu Trp Gln  Gln Ser Arg Phe Glu  Val Asn Glu 
    2960                 2965                 2970             


Thr His  Gly Ser Leu Thr Leu  Val Ala Gln Arg Ser  Arg Glu Pro 
    2975                 2980                 2985             


Leu Gly  His Val Ser Leu Phe  Val Tyr Ala Gln Asn  Leu Glu Ala 
    2990                 2995                 3000             


Gln Val  Gly Leu Asp Tyr Ile  Phe Thr Pro Met Ile  Leu His Phe 
    3005                 3010                 3015             


Ala Asp  Gly Glu Arg Tyr Lys  Asn Val Asn Ile Met  Ile Leu Asp 
    3020                 3025                 3030             


Asp Asp  Ile Pro Glu Gly Asp  Glu Lys Phe Gln Leu  Ile Leu Thr 
    3035                 3040                 3045             


Asn Pro  Ser Pro Gly Leu Glu  Leu Gly Lys Asn Thr  Ile Ala Leu 
    3050                 3055                 3060             


Ile Ile  Val Leu Ala Asn Asp  Asp Gly Pro Gly Val  Leu Ser Phe 
    3065                 3070                 3075             


Asn Asn  Ser Glu His Phe Phe  Leu Arg Glu Pro Thr  Ala Leu Tyr 
    3080                 3085                 3090             


Val Gln  Glu Ser Val Ala Val  Leu Tyr Ile Val Arg  Glu Pro Ala 
    3095                 3100                 3105             


Gln Gly  Leu Phe Gly Thr Val  Thr Val Gln Phe Ile  Val Thr Glu 
    3110                 3115                 3120             


Val Asn  Ser Ser Asn Glu Ser  Lys Asp Leu Thr Pro  Ser Lys Gly 
    3125                 3130                 3135             


Tyr Ile  Val Leu Glu Glu Gly  Val Arg Phe Lys Ala  Leu Gln Ile 
    3140                 3145                 3150             


Ser Ala  Ile Leu Asp Thr Glu  Pro Glu Met Asp Glu  Tyr Phe Val 
    3155                 3160                 3165             


Cys Thr  Leu Phe Asn Pro Thr  Gly Gly Ala Arg Leu  Gly Val His 
    3170                 3175                 3180             


Val Gln  Thr Leu Ile Thr Val  Leu Gln Asn Gln Ala  Pro Leu Gly 
    3185                 3190                 3195             


Leu Phe  Ser Ile Ser Ala Val  Glu Asn Arg Ala Thr  Ser Ile Asp 
    3200                 3205                 3210             


Ile Glu  Glu Ala Asn Arg Thr  Val Tyr Leu Asn Val  Ser Arg Thr 
    3215                 3220                 3225             


Asn Gly  Ile Asp Leu Ala Val  Ser Val Gln Trp Glu  Thr Val Ser 
    3230                 3235                 3240             


Glu Thr  Ala Phe Gly Met Arg  Gly Met Asp Val Val  Phe Ser Val 
    3245                 3250                 3255             


Phe Gln  Ser Phe Leu Asp Glu  Ser Ala Ser Gly Trp  Cys Phe Phe 
    3260                 3265                 3270             


Thr Leu  Glu Asn Leu Ile Tyr  Gly Ile Met Leu Arg  Lys Ser Ser 
    3275                 3280                 3285             


Val Thr  Val Tyr Arg Trp Gln  Gly Ile Phe Ile Pro  Val Glu Asp 
    3290                 3295                 3300             


Leu Asn  Ile Glu Asn Pro Lys  Thr Cys Glu Ala Phe  Asn Ile Gly 
    3305                 3310                 3315             


Phe Ser  Pro Tyr Phe Val Ile  Thr His Glu Glu Arg  Asn Glu Glu 
    3320                 3325                 3330             


Lys Pro  Ser Leu Asn Ser Val  Phe Thr Phe Thr Ser  Gly Phe Lys 
    3335                 3340                 3345             


Leu Phe  Leu Val Gln Thr Ile  Ile Ile Leu Glu Ser  Ser Gln Val 
    3350                 3355                 3360             


Arg Tyr  Phe Thr Ser Asp Ser  Gln Asp Tyr Leu Ile  Ile Ala Ser 
    3365                 3370                 3375             


Gln Arg  Asp Asp Ser Glu Leu  Thr Gln Val Phe Arg  Trp Asn Gly 
    3380                 3385                 3390             


Gly Ser  Phe Val Leu His Gln  Lys Leu Pro Val Arg  Gly Val Leu 
    3395                 3400                 3405             


Thr Val  Ala Leu Phe Asn Lys  Gly Gly Ser Val Phe  Leu Ala Ile 
    3410                 3415                 3420             


Ser Gln  Ala Asn Ala Arg Leu  Asn Ser Leu Leu Phe  Arg Trp Ser 
    3425                 3430                 3435             


Gly Ser  Gly Phe Ile Asn Phe  Gln Glu Val Pro Val  Ser Gly Thr 
    3440                 3445                 3450             


Thr Glu  Val Glu Ala Leu Ser  Ser Ala Asn Asp Ile  Tyr Leu Ile 
    3455                 3460                 3465             


Phe Ala  Glu Asn Val Phe Leu  Gly Asp Gln Asn Ser  Ile Asp Ile 
    3470                 3475                 3480             


Phe Ile  Trp Glu Met Gly Gln  Ser Ser Phe Arg Tyr  Phe Gln Ser 
    3485                 3490                 3495             


Val Asp  Phe Ala Ala Val Asn  Arg Ile His Ser Phe  Thr Pro Ala 
    3500                 3505                 3510             


Ser Gly  Ile Ala His Ile Leu  Leu Ile Gly Gln Asp  Met Ser Ala 
    3515                 3520                 3525             


Leu Tyr  Cys Trp Asn Ser Glu  Arg Asn Gln Phe Ser  Phe Val Leu 
    3530                 3535                 3540             


Glu Val  Pro Ser Ala Tyr Asp  Val Ala Ser Val Thr  Val Lys Ser 
    3545                 3550                 3555             


Leu Asn  Ser Ser Lys Asn Leu  Ile Ala Leu Val Gly  Ala His Ser 
    3560                 3565                 3570             


His Ile  Tyr Glu Leu Ala Tyr  Ile Ser Ser His Ser  Asp Phe Ile 
    3575                 3580                 3585             


Pro Ser  Ser Gly Glu Leu Ile  Phe Glu Pro Gly Glu  Arg Glu Ala 
    3590                 3595                 3600             


Thr Ile  Ala Val Asn Ile Leu  Asp Asp Thr Val Pro  Glu Lys Glu 
    3605                 3610                 3615             


Glu Ser  Phe Lys Val Gln Leu  Lys Asn Pro Lys Gly  Gly Ala Glu 
    3620                 3625                 3630             


Ile Gly  Ile Asn Asp Ser Val  Thr Ile Thr Ile Leu  Ser Asn Asp 
    3635                 3640                 3645             


Asp Ala  Tyr Gly Ile Val Ala  Phe Ala Gln Asn Ser  Leu Tyr Lys 
    3650                 3655                 3660             


Gln Val  Glu Glu Met Glu Gln  Asp Ser Leu Val Thr  Leu Asn Val 
    3665                 3670                 3675             


Glu Arg  Leu Lys Gly Thr Tyr  Gly Arg Ile Thr Ile  Ala Trp Glu 
    3680                 3685                 3690             


Ala Asp  Gly Ser Ile Ser Asp  Ile Phe Pro Thr Ser  Gly Val Ile 
    3695                 3700                 3705             


Leu Phe  Thr Glu Gly Gln Val  Leu Ser Thr Ile Thr  Leu Thr Ile 
    3710                 3715                 3720             


Leu Ala  Asp Asn Ile Pro Glu  Leu Ser Glu Val Val  Ile Val Thr 
    3725                 3730                 3735             


Leu Thr  Arg Ile Thr Thr Glu  Gly Val Glu Asp Ser  Tyr Lys Gly 
    3740                 3745                 3750             


Ala Thr  Ile Asp Gln Asp Arg  Ser Lys Ser Val Ile  Thr Thr Leu 
    3755                 3760                 3765             


Pro Asn  Asp Ser Pro Phe Gly  Leu Val Gly Trp Arg  Ala Ala Ser 
    3770                 3775                 3780             


Val Phe  Ile Arg Val Ala Glu  Pro Lys Glu Asn Thr  Thr Thr Leu 
    3785                 3790                 3795             


Gln Leu  Gln Ile Ala Arg Asp  Lys Gly Leu Leu Gly  Asp Ile Ala 
    3800                 3805                 3810             


Ile His  Leu Arg Ala Gln Pro  Asn Phe Leu Leu His  Val Asp Asn 
    3815                 3820                 3825             


Gln Ala  Thr Glu Asn Glu Asp  Tyr Val Leu Gln Glu  Thr Ile Ile 
    3830                 3835                 3840             


Ile Met  Lys Glu Asn Ile Lys  Glu Ala His Ala Glu  Val Ser Ile 
    3845                 3850                 3855             


Leu Pro  Asp Asp Leu Pro Glu  Leu Glu Glu Gly Phe  Ile Val Thr 
    3860                 3865                 3870             


Ile Thr  Glu Val Asn Leu Val  Asn Ser Asp Phe Ser  Thr Gly Gln 
    3875                 3880                 3885             


Pro Ser  Val Arg Arg Pro Gly  Met Glu Ile Ala Glu  Ile Met Ile 
    3890                 3895                 3900             


Glu Glu  Asn Asp Asp Pro Arg  Gly Ile Phe Met Phe  His Val Thr 
    3905                 3910                 3915             


Arg Gly  Ala Gly Glu Val Ile  Thr Ala Tyr Glu Val  Pro Pro Pro 
    3920                 3925                 3930             


Leu Asn  Val Leu Gln Val Pro  Val Val Arg Leu Ala  Gly Ser Phe 
    3935                 3940                 3945             


Gly Ala  Val Asn Val Tyr Trp  Lys Ala Ser Pro Asp  Ser Ala Gly 
    3950                 3955                 3960             


Leu Glu  Asp Phe Lys Pro Ser  His Gly Ile Leu Glu  Phe Ala Asp 
    3965                 3970                 3975             


Lys Gln  Val Thr Ala Met Ile  Glu Ile Thr Ile Ile  Asp Asp Ala 
    3980                 3985                 3990             


Glu Phe  Glu Leu Thr Glu Thr  Phe Asn Ile Ser Leu  Ile Ser Val 
    3995                 4000                 4005             


Ala Gly  Gly Gly Arg Leu Gly  Asp Asp Val Val Val  Thr Val Val 
    4010                 4015                 4020             


Ile Pro  Gln Asn Asp Ser Pro  Phe Gly Val Phe Gly  Phe Glu Glu 
    4025                 4030                 4035             


Lys Thr  Val Met Ile Asp Glu  Ser Leu Ser Ser Asp  Asp Pro Asp 
    4040                 4045                 4050             


Ser Tyr  Val Thr Leu Thr Val  Val Arg Ser Pro Gly  Gly Lys Gly 
    4055                 4060                 4065             


Thr Val  Arg Leu Glu Trp Thr  Ile Asp Glu Lys Ala  Lys His Asn 
    4070                 4075                 4080             


Leu Ser  Pro Leu Asn Gly Thr  Leu His Phe Asp Glu  Thr Glu Ser 
    4085                 4090                 4095             


Gln Lys  Thr Ile Val Leu His  Thr Leu Gln Asp Thr  Val Leu Glu 
    4100                 4105                 4110             


Glu Asp  Arg Arg Phe Thr Ile  Gln Leu Ile Ser Ile  Asp Glu Val 
    4115                 4120                 4125             


Glu Ile  Ser Pro Val Lys Gly  Ser Ala Ser Ile Ile  Ile Arg Gly 
    4130                 4135                 4140             


Asp Lys  Arg Ala Ser Gly Glu  Val Gly Ile Ala Pro  Ser Ser Arg 
    4145                 4150                 4155             


His Ile  Leu Ile Gly Glu Pro  Ser Ala Lys Tyr Asn  Gly Thr Ala 
    4160                 4165                 4170             


Ile Ile  Ser Leu Val Arg Gly  Pro Gly Ile Leu Gly  Glu Val Thr 
    4175                 4180                 4185             


Val Phe  Trp Arg Ile Phe Pro  Pro Ser Val Gly Glu  Phe Ala Glu 
    4190                 4195                 4200             


Thr Ser  Gly Lys Leu Thr Met  Arg Asp Glu Gln Ser  Ala Val Ile 
    4205                 4210                 4215             


Val Val  Ile Gln Ala Leu Asn  Asp Asp Ile Pro Glu  Glu Lys Ser 
    4220                 4225                 4230             


Phe Tyr  Glu Phe Gln Leu Thr  Ala Val Ser Glu Gly  Gly Val Leu 
    4235                 4240                 4245             


Ser Glu  Ser Ser Ser Thr Ala  Asn Ile Thr Val Val  Ala Ser Asp 
    4250                 4255                 4260             


Ser Pro  Tyr Gly Arg Phe Ala  Phe Ser His Glu Gln  Leu Arg Val 
    4265                 4270                 4275             


Ser Glu  Ala Gln Arg Val Asn  Ile Thr Ile Ile Arg  Ser Ser Gly 
    4280                 4285                 4290             


Asp Phe  Gly His Val Arg Leu  Trp Tyr Lys Thr Met  Ser Gly Thr 
    4295                 4300                 4305             


Ala Glu  Ala Gly Leu Asp Phe  Val Pro Ala Ala Gly  Glu Leu Leu 
    4310                 4315                 4320             


Phe Glu  Ala Gly Glu Met Arg  Lys Ser Leu His Val  Glu Ile Leu 
    4325                 4330                 4335             


Asp Asp  Asp Tyr Pro Glu Gly  Pro Glu Glu Phe Ser  Leu Thr Ile 
    4340                 4345                 4350             


Thr Lys  Val Glu Leu Gln Gly  Arg Gly Tyr Asp Phe  Thr Ile Gln 
    4355                 4360                 4365             


Glu Asn  Gly Leu Gln Ile Asp  Gln Pro Pro Glu Ile  Gly Asn Ile 
    4370                 4375                 4380             


Ser Ile  Val Arg Ile Ile Ile  Met Lys Asn Asp Asn  Ala Glu Gly 
    4385                 4390                 4395             


Ile Ile  Glu Phe Asp Pro Lys  Tyr Thr Ala Phe Glu  Val Glu Glu 
    4400                 4405                 4410             


Asp Val  Gly Leu Ile Met Ile  Pro Val Val Arg Leu  His Gly Thr 
    4415                 4420                 4425             


Tyr Gly  Tyr Val Thr Ala Asp  Phe Ile Ser Gln Ser  Ser Ser Ala 
    4430                 4435                 4440             


Ser Pro  Gly Gly Val Asp Tyr  Ile Leu His Gly Ser  Thr Val Thr 
    4445                 4450                 4455             


Phe Gln  His Gly Gln Asn Leu  Ser Phe Ile Asn Ile  Ser Ile Ile 
    4460                 4465                 4470             


Asp Asp  Asn Glu Ser Glu Phe  Glu Glu Pro Ile Glu  Ile Leu Leu 
    4475                 4480                 4485             


Thr Gly  Ala Thr Gly Gly Ala  Val Leu Gly Arg His  Leu Val Ser 
    4490                 4495                 4500             


Arg Ile  Ile Ile Ala Lys Ser  Asp Ser Pro Phe Gly  Val Ile Arg 
    4505                 4510                 4515             


Phe Leu  Asn Gln Ser Lys Ile  Ser Ile Ala Asn Pro  Asn Ser Thr 
    4520                 4525                 4530             


Met Ile  Leu Ser Leu Val Leu  Glu Arg Thr Gly Gly  Leu Leu Gly 
    4535                 4540                 4545             


Glu Ile  Gln Val Asn Trp Glu  Thr Val Gly Pro Asn  Ser Gln Glu 
    4550                 4555                 4560             


Ala Leu  Leu Pro Gln Asn Arg  Asp Ile Ala Asp Pro  Val Ser Gly 
    4565                 4570                 4575             


Leu Phe  Tyr Phe Gly Glu Gly  Glu Gly Gly Val Arg  Thr Ile Ile 
    4580                 4585                 4590             


Leu Thr  Ile Tyr Pro His Glu  Glu Ile Glu Val Glu  Glu Thr Phe 
    4595                 4600                 4605             


Ile Ile  Lys Leu His Leu Val  Lys Gly Glu Ala Lys  Leu Asp Ser 
    4610                 4615                 4620             


Arg Ala  Lys Asp Val Thr Leu  Thr Ile Gln Glu Phe  Gly Asp Pro 
    4625                 4630                 4635             


Asn Gly  Val Val Gln Phe Ala  Pro Glu Thr Leu Ser  Lys Lys Thr 
    4640                 4645                 4650             


Tyr Ser  Glu Pro Leu Ala Leu  Glu Gly Pro Leu Leu  Ile Thr Phe 
    4655                 4660                 4665             


Phe Val  Arg Arg Val Lys Gly  Thr Phe Gly Glu Ile  Met Val Tyr 
    4670                 4675                 4680             


Trp Glu  Leu Ser Ser Glu Phe  Asp Ile Thr Glu Asp  Phe Leu Ser 
    4685                 4690                 4695             


Thr Ser  Gly Phe Phe Thr Ile  Ala Asp Gly Glu Ser  Glu Ala Ser 
    4700                 4705                 4710             


Phe Asp  Val His Leu Leu Pro  Asp Glu Val Pro Glu  Ile Glu Glu 
    4715                 4720                 4725             


Asp Tyr  Val Ile Gln Leu Val  Ser Val Glu Gly Gly  Ala Glu Leu 
    4730                 4735                 4740             


Asp Leu  Glu Lys Ser Ile Thr  Trp Phe Ser Val Tyr  Ala Asn Asp 
    4745                 4750                 4755             


Asp Pro  His Gly Val Phe Ala  Leu Tyr Ser Asp Arg  Gln Ser Ile 
    4760                 4765                 4770             


Leu Ile  Gly Gln Asn Leu Ile  Arg Ser Ile Gln Ile  Asn Ile Thr 
    4775                 4780                 4785             


Arg Leu  Ala Gly Thr Phe Gly  Asp Val Ala Val Gly  Leu Arg Ile 
    4790                 4795                 4800             


Ser Ser  Asp His Lys Glu Gln  Pro Ile Val Thr Glu  Asn Ala Glu 
    4805                 4810                 4815             


Arg Gln  Leu Val Val Lys Asp  Gly Ala Thr Tyr Lys  Val Asp Val 
    4820                 4825                 4830             


Val Pro  Ile Lys Asn Gln Val  Phe Leu Ser Leu Gly  Ser Asn Phe 
    4835                 4840                 4845             


Thr Leu  Gln Leu Val Thr Val  Met Leu Val Gly Gly  Arg Phe Tyr 
    4850                 4855                 4860             


Gly Met  Pro Thr Ile Leu Gln  Glu Ala Lys Ser Ala  Val Leu Pro 
    4865                 4870                 4875             


Val Ser  Glu Lys Ala Ala Asn  Ser Gln Val Gly Phe  Glu Ser Thr 
    4880                 4885                 4890             


Ala Phe  Gln Leu Met Asn Ile  Thr Ala Gly Thr Ser  His Val Met 
    4895                 4900                 4905             


Ile Ser  Arg Arg Gly Thr Tyr  Gly Ala Leu Ser Val  Ala Trp Thr 
    4910                 4915                 4920             


Thr Gly  Tyr Ala Pro Gly Leu  Glu Ile Pro Glu Phe  Ile Val Val 
    4925                 4930                 4935             


Gly Asn  Met Thr Pro Thr Leu  Gly Ser Leu Ser Phe  Ser His Gly 
    4940                 4945                 4950             


Glu Gln  Arg Lys Gly Val Phe  Leu Trp Thr Phe Pro  Ser Pro Gly 
    4955                 4960                 4965             


Trp Pro  Glu Ala Phe Val Leu  His Leu Ser Gly Val  Gln Ser Ser 
    4970                 4975                 4980             


Ala Pro  Gly Gly Ala Gln Leu  Arg Ser Gly Phe Ile  Val Ala Glu 
    4985                 4990                 4995             


Ile Glu  Pro Met Gly Val Phe  Gln Phe Ser Thr Ser  Ser Arg Asn 
    5000                 5005                 5010             


Ile Ile  Val Ser Glu Asp Thr  Gln Met Ile Arg Leu  His Val Gln 
    5015                 5020                 5025             


Arg Leu  Phe Gly Phe His Ser  Asp Leu Ile Lys Val  Ser Tyr Gln 
    5030                 5035                 5040             


Thr Thr  Ala Gly Ser Ala Lys  Pro Leu Glu Asp Phe  Glu Pro Val 
    5045                 5050                 5055             


Gln Asn  Gly Glu Leu Phe Phe  Gln Lys Phe Gln Thr  Glu Val Asp 
    5060                 5065                 5070             


Phe Glu  Ile Thr Ile Ile Asn  Asp Gln Leu Ser Glu  Ile Glu Glu 
    5075                 5080                 5085             


Phe Phe  Tyr Ile Asn Leu Thr  Ser Val Glu Ile Arg  Gly Leu Gln 
    5090                 5095                 5100             


Lys Phe  Asp Val Asn Trp Ser  Pro Arg Leu Asn Leu  Asp Phe Ser 
    5105                 5110                 5115             


Val Ala  Val Ile Thr Ile Leu  Asp Asn Asp Asp Leu  Ala Gly Met 
    5120                 5125                 5130             


Asp Ile  Ser Phe Pro Glu Thr  Thr Val Ala Val Ala  Val Asp Thr 
    5135                 5140                 5145             


Thr Leu  Ile Pro Val Glu Thr  Glu Ser Thr Thr Tyr  Leu Ser Thr 
    5150                 5155                 5160             


Ser Lys  Thr Thr Thr Ile Leu  Gln Pro Thr Asn Val  Val Ala Ile 
    5165                 5170                 5175             


Val Thr  Glu Ala Thr Gly Val  Ser Ala Ile Pro Glu  Lys Leu Val 
    5180                 5185                 5190             


Thr Leu  His Gly Thr Pro Ala  Val Ser Glu Lys Pro  Asp Val Ala 
    5195                 5200                 5205             


Thr Val  Thr Ala Asn Val Ser  Ile His Gly Thr Phe  Ser Leu Gly 
    5210                 5215                 5220             


Pro Ser  Ile Val Tyr Ile Glu  Glu Glu Met Lys Asn  Gly Thr Phe 
    5225                 5230                 5235             


Asn Thr  Ala Glu Val Leu Ile  Arg Arg Thr Gly Gly  Phe Thr Gly 
    5240                 5245                 5250             


Asn Val  Ser Ile Thr Val Lys  Thr Phe Gly Glu Arg  Cys Ala Gln 
    5255                 5260                 5265             


Met Glu  Pro Asn Ala Leu Pro  Phe Arg Gly Ile Tyr  Gly Ile Ser 
    5270                 5275                 5280             


Asn Leu  Thr Trp Ala Val Glu  Glu Glu Asp Phe Glu  Glu Gln Thr 
    5285                 5290                 5295             


Leu Thr  Leu Ile Phe Leu Asp  Gly Glu Arg Glu Arg  Lys Val Ser 
    5300                 5305                 5310             


Val Gln  Ile Leu Asp Asp Asp  Glu Pro Glu Gly Gln  Glu Phe Phe 
    5315                 5320                 5325             


Tyr Val  Phe Leu Thr Asn Pro  Gln Gly Gly Ala Gln  Ile Val Glu 
    5330                 5335                 5340             


Glu Lys  Asp Asp Thr Gly Phe  Ala Ala Phe Ala Met  Val Ile Ile 
    5345                 5350                 5355             


Thr Gly  Ser Asp Leu His Asn  Gly Ile Ile Gly Phe  Ser Glu Glu 
    5360                 5365                 5370             


Ser Gln  Ser Gly Leu Glu Leu  Arg Glu Gly Ala Val  Met Arg Arg 
    5375                 5380                 5385             


Leu His  Leu Ile Val Thr Arg  Gln Pro Asn Arg Ala  Phe Glu Asp 
    5390                 5395                 5400             


Val Lys  Val Phe Trp Arg Val  Thr Leu Asn Lys Thr  Val Val Val 
    5405                 5410                 5415             


Leu Gln  Lys Asp Gly Val Asn  Leu Val Glu Glu Leu  Gln Ser Val 
    5420                 5425                 5430             


Ser Gly  Thr Thr Thr Cys Thr  Met Gly Gln Thr Lys  Cys Phe Ile 
    5435                 5440                 5445             


Ser Ile  Glu Leu Lys Pro Glu  Lys Val Pro Gln Val  Glu Val Tyr 
    5450                 5455                 5460             


Phe Phe  Val Glu Leu Tyr Glu  Ala Thr Ala Gly Ala  Ala Ile Asn 
    5465                 5470                 5475             


Asn Ser  Ala Arg Phe Ala Gln  Ile Lys Ile Leu Glu  Ser Asp Glu 
    5480                 5485                 5490             


Ser Gln  Ser Leu Val Tyr Phe  Ser Val Gly Ser Arg  Leu Ala Val 
    5495                 5500                 5505             


Ala His  Lys Lys Ala Thr Leu  Ile Ser Leu Gln Val  Ala Arg Asp 
    5510                 5515                 5520             


Ser Gly  Thr Gly Leu Met Met  Ser Val Asn Phe Ser  Thr Gln Glu 
    5525                 5530                 5535             


Leu Arg  Ser Ala Glu Thr Ile  Gly Arg Thr Ile Ile  Ser Pro Ala 
    5540                 5545                 5550             


Ile Ser  Gly Lys Asp Phe Val  Ile Thr Glu Gly Thr  Leu Val Phe 
    5555                 5560                 5565             


Glu Pro  Gly Gln Arg Ser Thr  Val Leu Asp Val Ile  Leu Thr Pro 
    5570                 5575                 5580             


Glu Thr  Gly Ser Leu Asn Ser  Phe Pro Lys Arg Phe  Gln Ile Val 
    5585                 5590                 5595             


Leu Phe  Asp Pro Lys Gly Gly  Ala Arg Ile Asp Lys  Val Tyr Gly 
    5600                 5605                 5610             


Thr Ala  Asn Ile Thr Leu Val  Ser Asp Ala Asp Ser  Gln Ala Ile 
    5615                 5620                 5625             


Trp Gly  Leu Ala Asp Gln Leu  His Gln Pro Val Asn  Asp Asp Ile 
    5630                 5635                 5640             


Leu Asn  Arg Val Leu His Thr  Ile Ser Met Lys Val  Ala Thr Glu 
    5645                 5650                 5655             


Asn Thr  Asp Glu Gln Leu Ser  Ala Met Met His Leu  Ile Glu Lys 
    5660                 5665                 5670             


Ile Thr  Thr Glu Gly Lys Ile  Gln Ala Phe Ser Val  Ala Ser Arg 
    5675                 5680                 5685             


Thr Leu  Phe Tyr Glu Ile Leu  Cys Ser Leu Ile Asn  Pro Lys Arg 
    5690                 5695                 5700             


Lys Asp  Thr Arg Gly Phe Ser  His Phe Ala Glu Val  Thr Glu Asn 
    5705                 5710                 5715             


Phe Ala  Phe Ser Leu Leu Thr  Asn Val Thr Cys Gly  Ser Pro Gly 
    5720                 5725                 5730             


Glu Lys  Ser Lys Thr Ile Leu  Asp Ser Cys Pro Tyr  Leu Ser Ile 
    5735                 5740                 5745             


Leu Ala  Leu His Trp Tyr Pro  Gln Gln Ile Asn Gly  His Lys Phe 
    5750                 5755                 5760             


Glu Gly  Lys Glu Gly Asp Tyr  Ile Arg Ile Pro Glu  Arg Leu Leu 
    5765                 5770                 5775             


Asp Val  Gln Asp Ala Glu Ile  Met Ala Gly Lys Ser  Thr Cys Lys 
    5780                 5785                 5790             


Leu Val  Gln Phe Thr Glu Tyr  Ser Ser Gln Gln Trp  Phe Ile Ser 
    5795                 5800                 5805             


Gly Asn  Asn Leu Pro Thr Leu  Lys Asn Lys Val Leu  Ser Leu Ser 
    5810                 5815                 5820             


Val Lys  Gly Gln Ser Ser Gln  Leu Leu Thr Asn Asp  Asn Glu Val 
    5825                 5830                 5835             


Leu Tyr  Arg Ile Tyr Ala Ala  Glu Pro Arg Ile Ile  Pro Gln Thr 
    5840                 5845                 5850             


Ser Leu  Cys Leu Leu Trp Asn  Gln Ala Ala Ala Ser  Trp Leu Ser 
    5855                 5860                 5865             


Asp Ser  Gln Phe Cys Lys Val  Val Glu Glu Thr Ala  Asp Tyr Val 
    5870                 5875                 5880             


Glu Cys  Ala Cys Ser His Met  Ser Val Tyr Ala Val  Tyr Ala Arg 
    5885                 5890                 5895             


Thr Asp  Asn Leu Ser Ser Tyr  Asn Glu Ala Phe Phe  Thr Ser Gly 
    5900                 5905                 5910             


Phe Ile  Cys Ile Ser Gly Leu  Cys Leu Ala Val Leu  Ser His Ile 
    5915                 5920                 5925             


Phe Cys  Ala Arg Tyr Ser Met  Phe Ala Ala Lys Leu  Leu Thr His 
    5930                 5935                 5940             


Met Met  Ala Ala Ser Leu Gly  Thr Gln Ile Leu Phe  Leu Ala Ser 
    5945                 5950                 5955             


Ala Tyr  Ala Ser Pro Gln Leu  Ala Glu Glu Ser Cys  Ser Ala Met 
    5960                 5965                 5970             


Ala Ala  Val Thr His Tyr Leu  Tyr Leu Cys Gln Phe  Ser Trp Met 
    5975                 5980                 5985             


Leu Ile  Gln Ser Val Asn Phe  Trp Tyr Val Leu Val  Met Asn Asp 
    5990                 5995                 6000             


Glu His  Thr Glu Arg Arg Tyr  Leu Leu Phe Phe Leu  Leu Ser Trp 
    6005                 6010                 6015             


Gly Leu  Pro Ala Phe Val Val  Ile Leu Leu Ile Val  Ile Leu Lys 
    6020                 6025                 6030             


Gly Ile  Tyr His Gln Ser Met  Ser Gln Ile Tyr Gly  Leu Ile His 
    6035                 6040                 6045             


Gly Asp  Leu Cys Phe Ile Pro  Asn Val Tyr Ala Ala  Leu Phe Thr 
    6050                 6055                 6060             


Ala Ala  Leu Val Pro Leu Thr  Cys Leu Val Val Val  Phe Val Val 
    6065                 6070                 6075             


Phe Ile  His Ala Tyr Gln Val  Lys Pro Gln Trp Lys  Ala Tyr Asp 
    6080                 6085                 6090             


Asp Val  Phe Arg Gly Arg Thr  Asn Ala Ala Glu Ile  Pro Leu Ile 
    6095                 6100                 6105             


Leu Tyr  Leu Phe Ala Leu Ile  Ser Val Thr Trp Leu  Trp Gly Gly 
    6110                 6115                 6120             


Leu His  Met Ala Tyr Arg His  Phe Trp Met Leu Val  Leu Phe Val 
    6125                 6130                 6135             


Ile Phe  Asn Ser Leu Gln Gly  Leu Tyr Val Phe Met  Val Tyr Phe 
    6140                 6145                 6150             


Ile Leu  His Asn Gln Met Cys  Cys Pro Met Lys Ala  Ser Tyr Thr 
    6155                 6160                 6165             


Val Glu  Met Asn Gly His Pro  Gly Pro Ser Thr Ala  Phe Phe Thr 
    6170                 6175                 6180             


Pro Gly  Ser Gly Met Pro Pro  Ala Gly Gly Glu Ile  Ser Lys Ser 
    6185                 6190                 6195             


Thr Gln  Asn Leu Ile Gly Ala  Met Glu Glu Val Pro  Pro Asp Trp 
    6200                 6205                 6210             


Glu Arg  Ala Ser Phe Gln Gln  Gly Ser Gln Ala Ser  Pro Asp Leu 
    6215                 6220                 6225             


Lys Pro  Ser Pro Gln Asn Gly  Ala Thr Phe Pro Ser  Ser Gly Gly 
    6230                 6235                 6240             


Tyr Gly  Gln Gly Ser Leu Ile  Ala Asp Glu Glu Ser  Gln Glu Phe 
    6245                 6250                 6255             


Asp Asp  Leu Ile Phe Ala Leu  Lys Thr Gly Ala Gly  Leu Ser Val 
    6260                 6265                 6270             


Ser Asp  Asn Glu Ser Gly Gln  Gly Ser Gln Glu Gly  Gly Thr Leu 
    6275                 6280                 6285             


Thr Asp  Ser Gln Ile Val Glu  Leu Arg Arg Ile Pro  Ile Ala Asp 
    6290                 6295                 6300             


Thr His  Leu 
    6305     


<210>  532
<211>  6306
<212>  PRT
<213>  Homo Sapiens

<400>  532

Met Ser Val Phe Leu Gly Pro Gly Met Pro Ser Ala Ser Leu Leu Val 
1               5                   10                  15      


Asn Leu Leu Ser Ala Leu Leu Ile Leu Phe Val Phe Gly Glu Thr Glu 
            20                  25                  30          


Ile Arg Phe Thr Gly Gln Thr Glu Phe Val Val Asn Glu Thr Ser Thr 
        35                  40                  45              


Thr Val Ile Arg Leu Ile Ile Glu Arg Ile Gly Glu Pro Ala Asn Val 
    50                  55                  60                  


Thr Ala Ile Val Ser Leu Tyr Gly Glu Asp Ala Gly Asp Phe Phe Asp 
65                  70                  75                  80  


Thr Tyr Ala Ala Ala Phe Ile Pro Ala Gly Glu Thr Asn Arg Thr Val 
                85                  90                  95      


Tyr Ile Ala Val Cys Asp Asp Asp Leu Pro Glu Pro Asp Glu Thr Phe 
            100                 105                 110         


Ile Phe His Leu Thr Leu Gln Lys Pro Ser Ala Asn Val Lys Leu Gly 
        115                 120                 125             


Trp Pro Arg Thr Val Thr Val Thr Ile Leu Ser Asn Asp Asn Ala Phe 
    130                 135                 140                 


Gly Ile Ile Ser Phe Asn Met Leu Pro Ser Ile Ala Val Ser Glu Pro 
145                 150                 155                 160 


Lys Gly Arg Asn Glu Ser Met Pro Leu Thr Leu Ile Arg Glu Lys Gly 
                165                 170                 175     


Thr Tyr Gly Met Val Met Val Thr Phe Glu Val Glu Gly Gly Pro Asn 
            180                 185                 190         


Pro Pro Asp Glu Asp Leu Ser Pro Val Lys Gly Asn Ile Thr Phe Pro 
        195                 200                 205             


Pro Gly Arg Ala Thr Val Ile Tyr Asn Leu Thr Val Leu Asp Asp Glu 
    210                 215                 220                 


Val Pro Glu Asn Asp Glu Ile Phe Leu Ile Gln Leu Lys Ser Val Glu 
225                 230                 235                 240 


Gly Gly Ala Glu Ile Asn Thr Ser Arg Asn Ser Ile Glu Ile Ile Ile 
                245                 250                 255     


Lys Lys Asn Asp Ser Pro Val Arg Phe Leu Gln Ser Ile Tyr Leu Val 
            260                 265                 270         


Pro Glu Glu Asp His Ile Leu Ile Ile Pro Val Val Arg Gly Lys Asp 
        275                 280                 285             


Asn Asn Gly Asn Leu Ile Gly Ser Asp Glu Tyr Glu Val Ser Ile Ser 
    290                 295                 300                 


Tyr Ala Val Thr Thr Gly Asn Ser Thr Ala His Ala Gln Gln Asn Leu 
305                 310                 315                 320 


Asp Phe Ile Asp Leu Gln Pro Asn Thr Thr Val Val Phe Pro Pro Phe 
                325                 330                 335     


Ile His Glu Ser His Leu Lys Phe Gln Ile Val Asp Asp Thr Ile Pro 
            340                 345                 350         


Glu Ile Ala Glu Ser Phe His Ile Met Leu Leu Lys Asp Thr Leu Gln 
        355                 360                 365             


Gly Asp Ala Val Leu Ile Ser Pro Ser Val Val Gln Val Thr Ile Lys 
    370                 375                 380                 


Pro Asn Asp Lys Pro Tyr Gly Val Leu Ser Phe Asn Ser Val Leu Phe 
385                 390                 395                 400 


Glu Arg Thr Val Ile Ile Asp Glu Asp Arg Ile Ser Arg Tyr Glu Glu 
                405                 410                 415     


Ile Thr Val Val Arg Asn Gly Gly Thr His Gly Asn Val Ser Ala Asn 
            420                 425                 430         


Trp Val Leu Thr Arg Asn Ser Thr Asp Pro Ser Pro Val Thr Ala Asp 
        435                 440                 445             


Ile Arg Pro Ser Ser Gly Val Leu His Phe Ala Gln Gly Gln Met Leu 
    450                 455                 460                 


Ala Thr Ile Pro Leu Thr Val Val Asp Asp Asp Leu Pro Glu Glu Ala 
465                 470                 475                 480 


Glu Ala Tyr Leu Leu Gln Ile Leu Pro His Thr Ile Arg Gly Gly Ala 
                485                 490                 495     


Glu Val Ser Glu Pro Ala Glu Leu Leu Phe Tyr Ile Gln Asp Ser Asp 
            500                 505                 510         


Asp Val Tyr Gly Leu Ile Thr Phe Phe Pro Met Glu Asn Gln Lys Ile 
        515                 520                 525             


Glu Ser Ser Pro Gly Glu Arg Tyr Leu Ser Leu Ser Phe Thr Arg Leu 
    530                 535                 540                 


Gly Gly Thr Lys Gly Asp Val Arg Leu Leu Tyr Ser Val Leu Tyr Ile 
545                 550                 555                 560 


Pro Ala Gly Ala Val Asp Pro Leu Gln Ala Lys Glu Gly Ile Leu Asn 
                565                 570                 575     


Ile Ser Arg Arg Asn Asp Leu Ile Phe Pro Glu Gln Lys Thr Gln Val 
            580                 585                 590         


Thr Thr Lys Leu Pro Ile Arg Asn Asp Ala Phe Leu Gln Asn Gly Ala 
        595                 600                 605             


His Phe Leu Val Gln Leu Glu Thr Val Glu Leu Leu Asn Ile Ile Pro 
    610                 615                 620                 


Leu Ile Pro Pro Ile Ser Pro Arg Phe Gly Glu Ile Cys Asn Ile Ser 
625                 630                 635                 640 


Leu Leu Val Thr Pro Ala Ile Ala Asn Gly Glu Ile Gly Phe Leu Ser 
                645                 650                 655     


Asn Leu Pro Ile Ile Leu His Glu Pro Glu Asp Phe Ala Ala Glu Val 
            660                 665                 670         


Val Tyr Ile Pro Leu His Arg Asp Gly Thr Asp Gly Gln Ala Thr Val 
        675                 680                 685             


Tyr Trp Ser Leu Lys Pro Ser Gly Phe Asn Ser Lys Ala Val Thr Pro 
    690                 695                 700                 


Asp Asp Ile Gly Pro Phe Asn Gly Ser Val Leu Phe Leu Ser Gly Gln 
705                 710                 715                 720 


Ser Asp Thr Thr Ile Asn Ile Thr Ile Lys Gly Asp Asp Ile Pro Glu 
                725                 730                 735     


Met Asn Glu Thr Val Thr Leu Ser Leu Asp Arg Val Asn Val Glu Asn 
            740                 745                 750         


Gln Val Leu Lys Ser Gly Tyr Thr Ser Arg Asp Leu Ile Ile Leu Glu 
        755                 760                 765             


Asn Asp Asp Pro Gly Gly Val Phe Glu Phe Ser Pro Ala Ser Arg Gly 
    770                 775                 780                 


Pro Tyr Val Ile Lys Glu Gly Glu Ser Val Glu Leu His Ile Ile Arg 
785                 790                 795                 800 


Ser Arg Gly Ser Leu Val Lys Gln Phe Leu His Tyr Arg Val Glu Pro 
                805                 810                 815     


Arg Asp Ser Asn Glu Phe Tyr Gly Asn Thr Gly Val Leu Glu Phe Lys 
            820                 825                 830         


Pro Gly Glu Arg Glu Ile Val Ile Thr Leu Leu Ala Arg Leu Asp Gly 
        835                 840                 845             


Ile Pro Glu Leu Asp Glu His Tyr Trp Val Val Leu Ser Ser His Gly 
    850                 855                 860                 


Glu Arg Glu Ser Lys Leu Gly Ser Ala Thr Ile Val Asn Ile Thr Ile 
865                 870                 875                 880 


Leu Lys Asn Asp Asp Pro His Gly Ile Ile Glu Phe Val Ser Asp Gly 
                885                 890                 895     


Leu Ile Val Met Ile Asn Glu Ser Lys Gly Asp Ala Ile Tyr Ser Ala 
            900                 905                 910         


Val Tyr Asp Val Val Arg Asn Arg Gly Asn Phe Gly Asp Val Ser Val 
        915                 920                 925             


Ser Trp Val Val Ser Pro Asp Phe Thr Gln Asp Val Phe Pro Val Gln 
    930                 935                 940                 


Gly Thr Val Val Phe Gly Asp Gln Glu Phe Ser Lys Asn Ile Thr Ile 
945                 950                 955                 960 


Tyr Ser Leu Pro Asp Glu Ile Pro Glu Glu Met Glu Glu Phe Thr Val 
                965                 970                 975     


Ile Leu Leu Asn Gly Thr Gly Gly Ala Lys Val Gly Asn Arg Thr Thr 
            980                 985                 990         


Ala Thr Leu Arg Ile Arg Arg Asn  Asp Asp Pro Ile Tyr  Phe Ala Glu 
        995                 1000                 1005             


Pro Arg  Val Val Arg Val Gln  Glu Gly Glu Thr Ala  Asn Phe Thr 
    1010                 1015                 1020             


Val Leu  Arg Asn Gly Ser Val  Asp Val Thr Cys Met  Val Gln Tyr 
    1025                 1030                 1035             


Ala Thr  Lys Asp Gly Lys Ala  Thr Ala Arg Glu Arg  Asp Phe Ile 
    1040                 1045                 1050             


Pro Val  Glu Lys Gly Glu Thr  Leu Ile Phe Glu Val  Gly Ser Arg 
    1055                 1060                 1065             


Gln Gln  Ser Ile Ser Ile Phe  Val Asn Glu Asp Gly  Ile Pro Glu 
    1070                 1075                 1080             


Thr Asp  Glu Pro Phe Tyr Ile  Ile Leu Leu Asn Ser  Thr Gly Asp 
    1085                 1090                 1095             


Thr Val  Val Tyr Gln Tyr Gly  Val Ala Thr Val Ile  Ile Glu Ala 
    1100                 1105                 1110             


Asn Asp  Asp Pro Asn Gly Ile  Phe Ser Leu Glu Pro  Ile Asp Lys 
    1115                 1120                 1125             


Ala Val  Glu Glu Gly Lys Thr  Asn Ala Phe Trp Ile  Leu Arg His 
    1130                 1135                 1140             


Arg Gly  Tyr Phe Gly Ser Val  Ser Val Ser Trp Gln  Leu Phe Gln 
    1145                 1150                 1155             


Asn Asp  Ser Ala Leu Gln Pro  Gly Gln Glu Phe Tyr  Glu Thr Ser 
    1160                 1165                 1170             


Gly Thr  Val Asn Phe Met Asp  Gly Glu Glu Ala Lys  Pro Ile Ile 
    1175                 1180                 1185             


Leu His  Ala Phe Pro Asp Lys  Ile Pro Glu Phe Asn  Glu Phe Tyr 
    1190                 1195                 1200             


Phe Leu  Lys Leu Val Asn Ile  Ser Gly Gly Ser Pro  Gly Pro Gly 
    1205                 1210                 1215             


Gly Gln  Leu Ala Glu Thr Asn  Leu Gln Val Thr Val  Met Val Pro 
    1220                 1225                 1230             


Phe Asn  Asp Asp Pro Phe Gly  Val Phe Ile Leu Asp  Pro Glu Cys 
    1235                 1240                 1245             


Leu Glu  Arg Glu Val Ala Glu  Asp Val Leu Ser Glu  Asp Asp Met 
    1250                 1255                 1260             


Ser Tyr  Ile Thr Asn Phe Thr  Ile Leu Arg Gln Gln  Gly Val Phe 
    1265                 1270                 1275             


Gly Asp  Val Gln Leu Gly Trp  Glu Ile Leu Ser Ser  Glu Phe Pro 
    1280                 1285                 1290             


Ala Gly  Leu Pro Pro Met Ile  Asp Phe Leu Leu Val  Gly Ile Phe 
    1295                 1300                 1305             


Pro Thr  Thr Val His Leu Gln  Gln His Met Arg Arg  His His Ser 
    1310                 1315                 1320             


Gly Thr  Asp Ala Leu Tyr Phe  Thr Gly Leu Glu Gly  Ala Phe Gly 
    1325                 1330                 1335             


Thr Val  Asn Pro Lys Tyr His  Pro Ser Arg Asn Asn  Thr Ile Ala 
    1340                 1345                 1350             


Asn Phe  Thr Phe Ser Ala Trp  Val Met Pro Asn Ala  Asn Thr Asn 
    1355                 1360                 1365             


Gly Phe  Ile Ile Ala Lys Asp  Asp Gly Asn Gly Ser  Ile Tyr Tyr 
    1370                 1375                 1380             


Gly Val  Lys Ile Gln Thr Asn  Glu Ser His Val Thr  Leu Ser Leu 
    1385                 1390                 1395             


His Tyr  Lys Thr Leu Gly Ser  Asn Ala Thr Tyr Ile  Ala Lys Thr 
    1400                 1405                 1410             


Thr Val  Met Lys Tyr Leu Glu  Glu Ser Val Trp Leu  His Leu Leu 
    1415                 1420                 1425             


Ile Ile  Leu Glu Asp Gly Ile  Ile Glu Phe Tyr Leu  Asp Gly Asn 
    1430                 1435                 1440             


Ala Met  Pro Arg Gly Ile Lys  Ser Leu Lys Gly Glu  Ala Ile Thr 
    1445                 1450                 1455             


Asp Gly  Pro Gly Ile Leu Arg  Ile Gly Ala Gly Ile  Asn Gly Asn 
    1460                 1465                 1470             


Asp Arg  Phe Thr Gly Leu Met  Gln Asp Val Arg Ser  Tyr Glu Arg 
    1475                 1480                 1485             


Lys Leu  Thr Leu Glu Glu Ile  Tyr Glu Leu His Ala  Met Pro Ala 
    1490                 1495                 1500             


Lys Ser  Asp Leu His Pro Ile  Ser Gly Tyr Leu Glu  Phe Arg Gln 
    1505                 1510                 1515             


Gly Glu  Thr Asn Lys Ser Phe  Ile Ile Ser Ala Arg  Asp Asp Asn 
    1520                 1525                 1530             


Asp Glu  Glu Gly Glu Glu Leu  Phe Ile Leu Lys Leu  Val Ser Val 
    1535                 1540                 1545             


Tyr Gly  Gly Ala Arg Ile Ser  Glu Glu Asn Thr Thr  Ala Arg Leu 
    1550                 1555                 1560             


Thr Ile  Gln Lys Ser Asp Asn  Ala Asn Gly Leu Phe  Gly Phe Thr 
    1565                 1570                 1575             


Gly Ala  Cys Ile Pro Glu Ile  Ala Glu Glu Gly Ser  Thr Ile Ser 
    1580                 1585                 1590             


Cys Val  Val Glu Arg Thr Arg  Gly Ala Leu Asp Tyr  Val His Val 
    1595                 1600                 1605             


Phe Tyr  Thr Ile Ser Gln Ile  Glu Thr Asp Gly Ile  Asn Tyr Leu 
    1610                 1615                 1620             


Val Asp  Asp Phe Ala Asn Ala  Ser Gly Thr Ile Thr  Phe Leu Pro 
    1625                 1630                 1635             


Trp Gln  Arg Ser Glu Val Leu  Asn Ile Tyr Val Leu  Asp Asp Asp 
    1640                 1645                 1650             


Ile Pro  Glu Leu Asn Glu Tyr  Phe Arg Val Thr Leu  Val Ser Ala 
    1655                 1660                 1665             


Ile Pro  Gly Asp Gly Lys Leu  Gly Ser Thr Pro Thr  Ser Gly Ala 
    1670                 1675                 1680             


Ser Ile  Asp Pro Glu Lys Glu  Thr Thr Asp Ile Thr  Ile Lys Ala 
    1685                 1690                 1695             


Ser Asp  His Pro Tyr Gly Leu  Leu Gln Phe Ser Thr  Gly Leu Pro 
    1700                 1705                 1710             


Pro Gln  Pro Lys Asp Ala Met  Thr Leu Pro Ala Ser  Ser Val Pro 
    1715                 1720                 1725             


His Ile  Thr Val Glu Glu Glu  Asp Gly Glu Ile Arg  Leu Leu Val 
    1730                 1735                 1740             


Ile Arg  Ala Gln Gly Leu Leu  Gly Arg Val Thr Ala  Glu Phe Arg 
    1745                 1750                 1755             


Thr Val  Ser Leu Thr Ala Phe  Ser Pro Glu Asp Tyr  Gln Asn Val 
    1760                 1765                 1770             


Ala Gly  Thr Leu Glu Phe Gln  Pro Gly Glu Arg Tyr  Lys Tyr Ile 
    1775                 1780                 1785             


Phe Ile  Asn Ile Thr Asp Asn  Ser Ile Pro Glu Leu  Glu Lys Ser 
    1790                 1795                 1800             


Phe Lys  Val Glu Leu Leu Asn  Leu Glu Gly Gly Val  Ala Glu Leu 
    1805                 1810                 1815             


Phe Arg  Val Asp Gly Ser Gly  Ser Gly Asp Gly Asp  Met Glu Phe 
    1820                 1825                 1830             


Phe Leu  Pro Thr Ile His Lys  Arg Ala Ser Leu Gly  Val Ala Ser 
    1835                 1840                 1845             


Gln Ile  Leu Val Thr Ile Ala  Ala Ser Asp His Ala  His Gly Val 
    1850                 1855                 1860             


Phe Glu  Phe Ser Pro Glu Ser  Leu Phe Val Ser Gly  Thr Glu Pro 
    1865                 1870                 1875             


Glu Asp  Gly Tyr Ser Thr Val  Thr Leu Asn Val Ile  Arg His His 
    1880                 1885                 1890             


Gly Thr  Leu Ser Pro Val Thr  Leu His Trp Asn Ile  Asp Ser Asp 
    1895                 1900                 1905             


Pro Asp  Gly Asp Leu Ala Phe  Thr Ser Gly Asn Ile  Thr Phe Glu 
    1910                 1915                 1920             


Ile Gly  Gln Thr Ser Ala Asn  Ile Thr Val Glu Ile  Leu Pro Asp 
    1925                 1930                 1935             


Glu Asp  Pro Glu Leu Asp Lys  Ala Phe Ser Val Ser  Val Leu Ser 
    1940                 1945                 1950             


Val Ser  Ser Gly Ser Leu Gly  Ala His Ile Asn Ala  Thr Leu Thr 
    1955                 1960                 1965             


Val Leu  Ala Ser Asp Asp Pro  Tyr Gly Ile Phe Ile  Phe Ser Glu 
    1970                 1975                 1980             


Lys Asn  Arg Pro Val Lys Val  Glu Glu Ala Thr Gln  Asn Ile Thr 
    1985                 1990                 1995             


Leu Ser  Ile Ile Arg Leu Lys  Gly Leu Met Gly Lys  Val Leu Val 
    2000                 2005                 2010             


Ser Tyr  Ala Thr Leu Asp Asp  Met Glu Lys Pro Pro  Tyr Phe Pro 
    2015                 2020                 2025             


Pro Asn  Leu Ala Arg Ala Thr  Gln Gly Arg Asp Tyr  Ile Pro Ala 
    2030                 2035                 2040             


Ser Gly  Phe Ala Leu Phe Gly  Ala Asn Gln Ser Glu  Ala Thr Ile 
    2045                 2050                 2055             


Ala Ile  Ser Ile Leu Asp Asp  Asp Glu Pro Glu Arg  Ser Glu Ser 
    2060                 2065                 2070             


Val Phe  Ile Glu Leu Leu Asn  Ser Thr Leu Val Ala  Lys Val Gln 
    2075                 2080                 2085             


Ser Arg  Ser Ile Pro Asn Ser  Pro Arg Leu Gly Pro  Lys Val Glu 
    2090                 2095                 2100             


Thr Ile  Ala Gln Leu Ile Ile  Ile Ala Asn Asp Asp  Ala Phe Gly 
    2105                 2110                 2115             


Thr Leu  Gln Leu Ser Ala Pro  Ile Val Arg Val Ala  Glu Asn His 
    2120                 2125                 2130             


Val Gly  Pro Ile Ile Asn Val  Thr Arg Thr Gly Gly  Ala Phe Ala 
    2135                 2140                 2145             


Asp Val  Ser Val Lys Phe Lys  Ala Val Pro Ile Thr  Ala Ile Ala 
    2150                 2155                 2160             


Gly Glu  Asp Tyr Ser Ile Ala  Ser Ser Asp Val Val  Leu Leu Glu 
    2165                 2170                 2175             


Gly Glu  Thr Ser Lys Ala Val  Pro Ile Tyr Val Ile  Asn Asp Ile 
    2180                 2185                 2190             


Tyr Pro  Glu Leu Glu Glu Ser  Phe Leu Val Gln Leu  Met Asn Glu 
    2195                 2200                 2205             


Thr Thr  Gly Gly Ala Arg Leu  Gly Ala Leu Thr Glu  Ala Val Ile 
    2210                 2215                 2220             


Ile Ile  Glu Ala Ser Asp Asp  Pro Tyr Gly Leu Phe  Gly Phe Gln 
    2225                 2230                 2235             


Ile Thr  Lys Leu Ile Val Glu  Glu Pro Glu Phe Asn  Ser Val Lys 
    2240                 2245                 2250             


Val Asn  Leu Pro Ile Ile Arg  Asn Ser Gly Thr Leu  Gly Asn Val 
    2255                 2260                 2265             


Thr Val  Gln Trp Val Ala Thr  Ile Asn Gly Gln Leu  Ala Thr Gly 
    2270                 2275                 2280             


Asp Leu  Arg Val Val Ser Gly  Asn Val Thr Phe Ala  Pro Gly Glu 
    2285                 2290                 2295             


Thr Ile  Gln Thr Leu Leu Leu  Glu Val Leu Ala Asp  Asp Val Pro 
    2300                 2305                 2310             


Glu Ile  Glu Glu Val Ile Gln  Val Gln Leu Thr Asp  Ala Ser Gly 
    2315                 2320                 2325             


Gly Gly  Thr Ile Gly Leu Asp  Arg Ile Ala Asn Ile  Ile Ile Pro 
    2330                 2335                 2340             


Ala Asn  Asp Asp Pro Tyr Gly  Thr Val Ala Phe Ala  Gln Met Val 
    2345                 2350                 2355             


Tyr Arg  Val Gln Glu Pro Leu  Glu Arg Ser Ser Cys  Ala Asn Ile 
    2360                 2365                 2370             


Thr Val  Arg Arg Ser Gly Gly  His Phe Gly Arg Leu  Leu Leu Phe 
    2375                 2380                 2385             


Tyr Ser  Thr Ser Asp Ile Asp  Val Val Ala Leu Ala  Met Glu Glu 
    2390                 2395                 2400             


Gly Gln  Asp Leu Leu Ser Tyr  Tyr Glu Ser Pro Ile  Gln Gly Val 
    2405                 2410                 2415             


Pro Asp  Pro Leu Trp Arg Thr  Trp Met Asn Val Ser  Ala Val Gly 
    2420                 2425                 2430             


Glu Pro  Leu Tyr Thr Cys Ala  Thr Leu Cys Leu Lys  Glu Gln Ala 
    2435                 2440                 2445             


Cys Ser  Ala Phe Ser Phe Phe  Ser Ala Ser Glu Gly  Pro Gln Cys 
    2450                 2455                 2460             


Phe Trp  Met Thr Ser Trp Ile  Ser Pro Ala Val Asn  Asn Ser Asp 
    2465                 2470                 2475             


Phe Trp  Thr Tyr Arg Lys Asn  Met Thr Arg Val Ala  Ser Leu Phe 
    2480                 2485                 2490             


Ser Gly  Gln Ala Val Ala Gly  Ser Asp Tyr Glu Pro  Val Thr Arg 
    2495                 2500                 2505             


Gln Trp  Ala Ile Met Gln Glu  Gly Asp Glu Phe Ala  Asn Leu Thr 
    2510                 2515                 2520             


Val Ser  Ile Leu Pro Asp Asp  Phe Pro Glu Met Asp  Glu Ser Phe 
    2525                 2530                 2535             


Leu Ile  Ser Leu Leu Glu Val  His Leu Met Asn Ile  Ser Ala Ser 
    2540                 2545                 2550             


Leu Lys  Asn Gln Pro Thr Ile  Gly Gln Pro Asn Ile  Ser Thr Val 
    2555                 2560                 2565             


Val Ile  Ala Leu Asn Gly Asp  Ala Phe Gly Val Phe  Val Ile Tyr 
    2570                 2575                 2580             


Asn Ile  Ser Pro Asn Thr Ser  Glu Asp Gly Leu Phe  Val Glu Val 
    2585                 2590                 2595             


Gln Glu  Gln Pro Gln Thr Leu  Val Glu Leu Met Ile  His Arg Thr 
    2600                 2605                 2610             


Gly Gly  Ser Leu Gly Gln Val  Ala Val Glu Trp Arg  Val Val Gly 
    2615                 2620                 2625             


Gly Thr  Ala Thr Glu Gly Leu  Asp Phe Ile Gly Ala  Gly Glu Ile 
    2630                 2635                 2640             


Leu Thr  Phe Ala Glu Gly Glu  Thr Lys Lys Thr Val  Ile Leu Thr 
    2645                 2650                 2655             


Ile Leu  Asp Asp Ser Glu Pro  Glu Asp Asp Glu Ser  Ile Ile Val 
    2660                 2665                 2670             


Ser Leu  Val Tyr Thr Glu Gly  Gly Ser Arg Ile Leu  Pro Ser Ser 
    2675                 2680                 2685             


Asp Thr  Val Arg Val Asn Ile  Leu Ala Asn Asp Asn  Val Ala Gly 
    2690                 2695                 2700             


Ile Val  Ser Phe Gln Thr Ala  Ser Arg Ser Val Ile  Gly His Glu 
    2705                 2710                 2715             


Gly Glu  Ile Leu Gln Phe His  Val Ile Arg Thr Phe  Pro Gly Arg 
    2720                 2725                 2730             


Gly Asn  Val Thr Val Asn Trp  Lys Ile Ile Gly Gln  Asn Leu Glu 
    2735                 2740                 2745             


Leu Asn  Phe Ala Asn Phe Ser  Gly Gln Leu Phe Phe  Pro Glu Gly 
    2750                 2755                 2760             


Ser Leu  Asn Thr Thr Leu Phe  Val His Leu Leu Asp  Asp Asn Ile 
    2765                 2770                 2775             


Pro Glu  Glu Lys Glu Val Tyr  Gln Val Ile Leu Tyr  Asp Val Arg 
    2780                 2785                 2790             


Thr Gln  Gly Val Pro Pro Ala  Gly Ile Ala Leu Leu  Asp Ala Gln 
    2795                 2800                 2805             


Gly Tyr  Ala Ala Val Leu Thr  Val Glu Ala Ser Asp  Glu Pro His 
    2810                 2815                 2820             


Gly Val  Leu Asn Phe Ala Leu  Ser Ser Arg Phe Val  Leu Leu Gln 
    2825                 2830                 2835             


Glu Ala  Asn Ile Thr Ile Gln  Leu Phe Ile Asn Arg  Glu Phe Gly 
    2840                 2845                 2850             


Ser Leu  Gly Ala Ile Asn Val  Thr Tyr Thr Thr Val  Pro Gly Met 
    2855                 2860                 2865             


Leu Ser  Leu Lys Asn Gln Thr  Val Gly Asn Leu Ala  Glu Pro Glu 
    2870                 2875                 2880             


Val Asp  Phe Val Pro Ile Ile  Gly Phe Leu Ile Leu  Glu Glu Gly 
    2885                 2890                 2895             


Glu Thr  Ala Ala Ala Ile Asn  Ile Thr Ile Leu Glu  Asp Asp Val 
    2900                 2905                 2910             


Pro Glu  Leu Glu Glu Tyr Phe  Leu Val Asn Leu Thr  Tyr Val Gly 
    2915                 2920                 2925             


Leu Thr  Met Ala Ala Ser Thr  Ser Phe Pro Pro Arg  Leu Asp Ser 
    2930                 2935                 2940             


Glu Gly  Leu Thr Ala Gln Val  Ile Ile Asp Ala Asn  Asp Gly Ala 
    2945                 2950                 2955             


Arg Gly  Val Ile Glu Trp Gln  Gln Ser Arg Phe Glu  Val Asn Glu 
    2960                 2965                 2970             


Thr His  Gly Ser Leu Thr Leu  Val Ala Gln Arg Ser  Arg Glu Pro 
    2975                 2980                 2985             


Leu Gly  His Val Ser Leu Phe  Val Tyr Ala Gln Asn  Leu Glu Ala 
    2990                 2995                 3000             


Gln Val  Gly Leu Asp Tyr Ile  Phe Thr Pro Met Ile  Leu His Phe 
    3005                 3010                 3015             


Ala Asp  Gly Glu Arg Tyr Lys  Asn Val Asn Ile Met  Ile Leu Asp 
    3020                 3025                 3030             


Asp Asp  Ile Pro Glu Gly Asp  Glu Lys Phe Gln Leu  Ile Leu Thr 
    3035                 3040                 3045             


Asn Pro  Ser Pro Gly Leu Glu  Leu Gly Lys Asn Thr  Ile Ala Leu 
    3050                 3055                 3060             


Ile Ile  Val Leu Ala Asn Asp  Asp Gly Pro Gly Val  Leu Ser Phe 
    3065                 3070                 3075             


Asn Asn  Ser Glu His Phe Phe  Leu Arg Glu Pro Thr  Ala Leu Tyr 
    3080                 3085                 3090             


Val Gln  Glu Ser Val Ala Val  Leu Tyr Ile Val Arg  Glu Pro Ala 
    3095                 3100                 3105             


Gln Gly  Leu Phe Gly Thr Val  Thr Val Gln Phe Ile  Val Thr Glu 
    3110                 3115                 3120             


Val Asn  Ser Ser Asn Glu Ser  Lys Asp Leu Thr Pro  Ser Lys Gly 
    3125                 3130                 3135             


Tyr Ile  Val Leu Glu Glu Gly  Val Arg Phe Lys Ala  Leu Gln Ile 
    3140                 3145                 3150             


Ser Ala  Ile Leu Asp Thr Glu  Pro Glu Met Asp Glu  Tyr Phe Val 
    3155                 3160                 3165             


Cys Thr  Leu Phe Asn Pro Thr  Gly Gly Ala Arg Leu  Gly Val His 
    3170                 3175                 3180             


Val Gln  Thr Leu Ile Thr Val  Leu Gln Asn Gln Ala  Pro Leu Gly 
    3185                 3190                 3195             


Leu Phe  Ser Ile Ser Ala Val  Glu Asn Arg Ala Thr  Ser Ile Asp 
    3200                 3205                 3210             


Ile Glu  Glu Ala Asn Arg Thr  Val Tyr Leu Asn Val  Ser Arg Thr 
    3215                 3220                 3225             


Asn Gly  Ile Asp Leu Ala Val  Ser Val Gln Trp Glu  Thr Val Ser 
    3230                 3235                 3240             


Glu Thr  Ala Phe Gly Met Arg  Gly Met Asp Val Val  Phe Ser Val 
    3245                 3250                 3255             


Phe Gln  Ser Phe Leu Asp Glu  Ser Ala Ser Gly Trp  Cys Phe Phe 
    3260                 3265                 3270             


Thr Leu  Glu Asn Leu Ile Tyr  Gly Ile Met Leu Arg  Lys Ser Ser 
    3275                 3280                 3285             


Val Thr  Val Tyr Arg Trp Gln  Gly Ile Phe Ile Pro  Val Glu Asp 
    3290                 3295                 3300             


Leu Asn  Ile Glu Asn Pro Lys  Thr Cys Glu Ala Phe  Asn Ile Gly 
    3305                 3310                 3315             


Phe Ser  Pro Tyr Phe Val Ile  Thr His Glu Glu Arg  Asn Glu Glu 
    3320                 3325                 3330             


Lys Pro  Ser Leu Asn Ser Val  Phe Thr Phe Thr Ser  Gly Phe Lys 
    3335                 3340                 3345             


Leu Phe  Leu Val Gln Thr Ile  Ile Ile Leu Glu Ser  Ser Gln Val 
    3350                 3355                 3360             


Arg Tyr  Phe Thr Ser Asp Ser  Gln Asp Tyr Leu Ile  Ile Ala Ser 
    3365                 3370                 3375             


Gln Arg  Asp Asp Ser Glu Leu  Thr Gln Val Phe Arg  Trp Asn Gly 
    3380                 3385                 3390             


Gly Ser  Phe Val Leu His Gln  Lys Leu Pro Val Arg  Gly Val Leu 
    3395                 3400                 3405             


Thr Val  Ala Leu Phe Asn Lys  Gly Gly Ser Val Phe  Leu Ala Ile 
    3410                 3415                 3420             


Ser Gln  Ala Asn Ala Arg Leu  Asn Ser Leu Leu Phe  Arg Trp Ser 
    3425                 3430                 3435             


Gly Ser  Gly Phe Ile Asn Phe  Gln Glu Val Pro Val  Ser Gly Thr 
    3440                 3445                 3450             


Thr Glu  Val Glu Ala Leu Ser  Ser Ala Asn Asp Ile  Tyr Leu Ile 
    3455                 3460                 3465             


Phe Ala  Glu Asn Val Phe Leu  Gly Asp Gln Asn Ser  Ile Asp Ile 
    3470                 3475                 3480             


Phe Ile  Trp Glu Met Gly Gln  Ser Ser Phe Arg Tyr  Phe Gln Ser 
    3485                 3490                 3495             


Val Asp  Phe Ala Ala Val Asn  Arg Ile His Ser Phe  Thr Pro Ala 
    3500                 3505                 3510             


Ser Gly  Ile Ala His Ile Leu  Leu Ile Gly Gln Asp  Met Ser Ala 
    3515                 3520                 3525             


Leu Tyr  Cys Trp Asn Ser Glu  Arg Asn Gln Phe Ser  Phe Val Leu 
    3530                 3535                 3540             


Glu Val  Pro Ser Ala Tyr Asp  Val Ala Ser Val Thr  Val Lys Ser 
    3545                 3550                 3555             


Leu Asn  Ser Ser Lys Asn Leu  Ile Ala Leu Val Gly  Ala His Ser 
    3560                 3565                 3570             


His Ile  Tyr Glu Leu Ala Tyr  Ile Ser Ser His Ser  Asp Phe Ile 
    3575                 3580                 3585             


Pro Ser  Ser Gly Glu Leu Ile  Phe Glu Pro Gly Glu  Arg Glu Ala 
    3590                 3595                 3600             


Thr Ile  Ala Val Asn Ile Leu  Asp Asp Thr Val Pro  Glu Lys Glu 
    3605                 3610                 3615             


Glu Ser  Phe Lys Val Gln Leu  Lys Asn Pro Lys Gly  Gly Ala Glu 
    3620                 3625                 3630             


Ile Gly  Ile Asn Asp Ser Val  Thr Ile Thr Ile Leu  Ser Asn Asp 
    3635                 3640                 3645             


Asp Ala  Tyr Gly Ile Val Ala  Phe Ala Gln Asn Ser  Leu Tyr Lys 
    3650                 3655                 3660             


Gln Val  Glu Glu Met Glu Gln  Asp Ser Leu Val Thr  Leu Asn Val 
    3665                 3670                 3675             


Glu Arg  Leu Lys Gly Thr Tyr  Gly Arg Ile Thr Ile  Ala Trp Glu 
    3680                 3685                 3690             


Ala Asp  Gly Ser Ile Ser Asp  Ile Phe Pro Thr Ser  Gly Val Ile 
    3695                 3700                 3705             


Leu Phe  Thr Glu Gly Gln Val  Leu Ser Thr Ile Thr  Leu Thr Ile 
    3710                 3715                 3720             


Leu Ala  Asp Asn Ile Pro Glu  Leu Ser Glu Val Val  Ile Val Thr 
    3725                 3730                 3735             


Leu Thr  Arg Ile Thr Thr Glu  Gly Val Glu Asp Ser  Tyr Lys Gly 
    3740                 3745                 3750             


Ala Thr  Ile Asp Gln Asp Arg  Ser Lys Ser Val Ile  Thr Thr Leu 
    3755                 3760                 3765             


Pro Asn  Asp Ser Pro Phe Gly  Leu Val Gly Trp Arg  Ala Ala Ser 
    3770                 3775                 3780             


Val Phe  Ile Arg Val Ala Glu  Pro Lys Glu Asn Thr  Thr Thr Leu 
    3785                 3790                 3795             


Gln Leu  Gln Ile Ala Arg Asp  Lys Gly Leu Leu Gly  Asp Ile Ala 
    3800                 3805                 3810             


Ile His  Leu Arg Ala Gln Pro  Asn Phe Leu Leu His  Val Asp Asn 
    3815                 3820                 3825             


Gln Ala  Thr Glu Asn Glu Asp  Tyr Val Leu Gln Glu  Thr Ile Ile 
    3830                 3835                 3840             


Ile Met  Lys Glu Asn Ile Lys  Glu Ala His Ala Glu  Val Ser Ile 
    3845                 3850                 3855             


Leu Pro  Asp Asp Leu Pro Glu  Leu Glu Glu Gly Phe  Ile Val Thr 
    3860                 3865                 3870             


Ile Thr  Glu Val Asn Leu Val  Asn Ser Asp Phe Ser  Thr Gly Gln 
    3875                 3880                 3885             


Pro Ser  Val Arg Arg Pro Gly  Met Glu Ile Ala Glu  Ile Met Ile 
    3890                 3895                 3900             


Glu Glu  Asn Asp Asp Pro Arg  Gly Ile Phe Met Phe  His Val Thr 
    3905                 3910                 3915             


Arg Gly  Ala Gly Glu Val Ile  Thr Ala Tyr Glu Val  Pro Pro Pro 
    3920                 3925                 3930             


Leu Asn  Val Leu Gln Val Pro  Val Val Arg Leu Ala  Gly Ser Phe 
    3935                 3940                 3945             


Gly Ala  Val Asn Val Tyr Trp  Lys Ala Ser Pro Asp  Ser Ala Gly 
    3950                 3955                 3960             


Leu Glu  Asp Phe Lys Pro Ser  His Gly Ile Leu Glu  Phe Ala Asp 
    3965                 3970                 3975             


Lys Gln  Val Thr Ala Met Ile  Glu Ile Thr Ile Ile  Asp Asp Ala 
    3980                 3985                 3990             


Glu Phe  Glu Leu Thr Glu Thr  Phe Asn Ile Ser Leu  Ile Ser Val 
    3995                 4000                 4005             


Ala Gly  Gly Gly Arg Leu Gly  Asp Asp Val Val Val  Thr Val Val 
    4010                 4015                 4020             


Ile Pro  Gln Asn Asp Ser Pro  Phe Gly Val Phe Gly  Phe Glu Glu 
    4025                 4030                 4035             


Lys Thr  Val Met Ile Asp Glu  Ser Leu Ser Ser Asp  Asp Pro Asp 
    4040                 4045                 4050             


Ser Tyr  Val Thr Leu Thr Val  Val Arg Ser Pro Gly  Gly Lys Gly 
    4055                 4060                 4065             


Thr Val  Arg Leu Glu Trp Thr  Ile Asp Glu Lys Ala  Lys His Asn 
    4070                 4075                 4080             


Leu Ser  Pro Leu Asn Gly Thr  Leu His Phe Asp Glu  Thr Glu Ser 
    4085                 4090                 4095             


Gln Lys  Thr Ile Val Leu His  Thr Leu Gln Asp Thr  Val Leu Glu 
    4100                 4105                 4110             


Glu Asp  Arg Arg Phe Thr Ile  Gln Leu Ile Ser Ile  Asp Glu Val 
    4115                 4120                 4125             


Glu Ile  Ser Pro Val Lys Gly  Ser Ala Ser Ile Ile  Ile Arg Gly 
    4130                 4135                 4140             


Asp Lys  Arg Ala Ser Gly Glu  Val Gly Ile Ala Pro  Ser Ser Arg 
    4145                 4150                 4155             


His Ile  Leu Ile Gly Glu Pro  Ser Ala Lys Tyr Asn  Gly Thr Ala 
    4160                 4165                 4170             


Ile Ile  Ser Leu Val Arg Gly  Pro Gly Ile Leu Gly  Glu Val Thr 
    4175                 4180                 4185             


Val Phe  Trp Arg Ile Phe Pro  Pro Ser Val Gly Glu  Phe Ala Glu 
    4190                 4195                 4200             


Thr Ser  Gly Lys Leu Thr Met  Arg Asp Glu Gln Ser  Ala Val Ile 
    4205                 4210                 4215             


Val Val  Ile Gln Ala Leu Asn  Asp Asp Ile Pro Glu  Glu Lys Ser 
    4220                 4225                 4230             


Phe Tyr  Glu Phe Gln Leu Thr  Ala Val Ser Glu Gly  Gly Val Leu 
    4235                 4240                 4245             


Ser Glu  Ser Ser Ser Thr Ala  Asn Ile Thr Val Val  Ala Ser Asp 
    4250                 4255                 4260             


Ser Pro  Tyr Gly Arg Phe Ala  Phe Ser His Glu Gln  Leu Arg Val 
    4265                 4270                 4275             


Ser Glu  Ala Gln Arg Val Asn  Ile Thr Ile Ile Arg  Ser Ser Gly 
    4280                 4285                 4290             


Asp Phe  Gly His Val Arg Leu  Trp Tyr Lys Thr Met  Ser Gly Thr 
    4295                 4300                 4305             


Ala Glu  Ala Gly Leu Asp Phe  Val Pro Ala Ala Gly  Glu Leu Leu 
    4310                 4315                 4320             


Phe Glu  Ala Gly Glu Met Arg  Lys Ser Leu His Val  Glu Ile Leu 
    4325                 4330                 4335             


Asp Asp  Asp Tyr Pro Glu Gly  Pro Glu Glu Phe Ser  Leu Thr Ile 
    4340                 4345                 4350             


Thr Lys  Val Glu Leu Gln Gly  Arg Gly Tyr Asp Phe  Thr Ile Gln 
    4355                 4360                 4365             


Glu Asn  Gly Leu Gln Ile Asp  Gln Pro Pro Glu Ile  Gly Asn Ile 
    4370                 4375                 4380             


Ser Ile  Val Arg Ile Ile Ile  Met Lys Asn Asp Asn  Ala Glu Gly 
    4385                 4390                 4395             


Ile Ile  Glu Phe Asp Pro Lys  Tyr Thr Ala Phe Glu  Val Glu Glu 
    4400                 4405                 4410             


Asp Val  Gly Leu Ile Met Ile  Pro Val Val Arg Leu  His Gly Thr 
    4415                 4420                 4425             


Tyr Gly  Tyr Val Thr Ala Asp  Phe Ile Ser Gln Ser  Ser Ser Ala 
    4430                 4435                 4440             


Ser Pro  Gly Gly Val Asp Tyr  Ile Leu His Gly Ser  Thr Val Thr 
    4445                 4450                 4455             


Phe Gln  His Gly Gln Asn Leu  Ser Phe Ile Asn Ile  Ser Ile Ile 
    4460                 4465                 4470             


Asp Asp  Asn Glu Ser Glu Phe  Glu Glu Pro Ile Glu  Ile Leu Leu 
    4475                 4480                 4485             


Thr Gly  Ala Thr Gly Gly Ala  Val Leu Gly Arg His  Leu Val Ser 
    4490                 4495                 4500             


Arg Ile  Ile Ile Ala Lys Ser  Asp Ser Pro Phe Gly  Val Ile Arg 
    4505                 4510                 4515             


Phe Leu  Asn Gln Ser Lys Ile  Ser Ile Ala Asn Pro  Asn Ser Thr 
    4520                 4525                 4530             


Met Ile  Leu Ser Leu Val Leu  Glu Arg Thr Gly Gly  Leu Leu Gly 
    4535                 4540                 4545             


Glu Ile  Gln Val Asn Trp Glu  Thr Val Gly Pro Asn  Ser Gln Glu 
    4550                 4555                 4560             


Ala Leu  Leu Pro Gln Asn Arg  Asp Ile Ala Asp Pro  Val Ser Gly 
    4565                 4570                 4575             


Leu Phe  Tyr Phe Gly Glu Gly  Glu Gly Gly Val Arg  Thr Ile Ile 
    4580                 4585                 4590             


Leu Thr  Ile Tyr Pro His Glu  Glu Ile Glu Val Glu  Glu Thr Phe 
    4595                 4600                 4605             


Ile Ile  Lys Leu His Leu Val  Lys Gly Glu Ala Lys  Leu Asp Ser 
    4610                 4615                 4620             


Arg Ala  Lys Asp Val Thr Leu  Thr Ile Gln Glu Phe  Gly Asp Pro 
    4625                 4630                 4635             


Asn Gly  Val Val Gln Phe Ala  Pro Glu Thr Leu Ser  Lys Lys Thr 
    4640                 4645                 4650             


Tyr Ser  Glu Pro Leu Ala Leu  Glu Gly Pro Leu Leu  Ile Thr Phe 
    4655                 4660                 4665             


Phe Val  Arg Arg Val Lys Gly  Thr Phe Gly Glu Ile  Met Val Tyr 
    4670                 4675                 4680             


Trp Glu  Leu Ser Ser Glu Phe  Asp Ile Thr Glu Asp  Phe Leu Ser 
    4685                 4690                 4695             


Thr Ser  Gly Phe Phe Thr Ile  Ala Asp Gly Glu Ser  Glu Ala Ser 
    4700                 4705                 4710             


Phe Asp  Val His Leu Leu Pro  Asp Glu Val Pro Glu  Ile Glu Glu 
    4715                 4720                 4725             


Asp Tyr  Val Ile Gln Leu Val  Ser Val Glu Gly Gly  Ala Glu Leu 
    4730                 4735                 4740             


Asp Leu  Glu Lys Ser Ile Thr  Trp Phe Ser Val Tyr  Ala Asn Asp 
    4745                 4750                 4755             


Asp Pro  His Gly Val Phe Ala  Leu Tyr Ser Asp Arg  Gln Ser Ile 
    4760                 4765                 4770             


Leu Ile  Gly Gln Asn Leu Ile  Arg Ser Ile Gln Ile  Asn Ile Thr 
    4775                 4780                 4785             


Arg Leu  Ala Gly Thr Phe Gly  Asp Val Ala Val Gly  Leu Arg Ile 
    4790                 4795                 4800             


Ser Ser  Asp His Lys Glu Gln  Pro Ile Val Thr Glu  Asn Ala Glu 
    4805                 4810                 4815             


Arg Gln  Leu Val Val Lys Asp  Gly Ala Thr Tyr Lys  Val Asp Val 
    4820                 4825                 4830             


Val Pro  Ile Lys Asn Gln Val  Phe Leu Ser Leu Gly  Ser Asn Phe 
    4835                 4840                 4845             


Thr Leu  Gln Leu Val Thr Val  Met Leu Val Gly Gly  Arg Phe Tyr 
    4850                 4855                 4860             


Gly Met  Pro Thr Ile Leu Gln  Glu Ala Lys Ser Ala  Val Leu Pro 
    4865                 4870                 4875             


Val Ser  Glu Lys Ala Ala Asn  Ser Gln Val Gly Phe  Glu Ser Thr 
    4880                 4885                 4890             


Ala Phe  Gln Leu Met Asn Ile  Thr Ala Gly Thr Ser  His Val Met 
    4895                 4900                 4905             


Ile Ser  Arg Arg Gly Thr Tyr  Gly Ala Leu Ser Val  Ala Trp Thr 
    4910                 4915                 4920             


Thr Gly  Tyr Ala Pro Gly Leu  Glu Ile Pro Glu Phe  Ile Val Val 
    4925                 4930                 4935             


Gly Asn  Met Thr Pro Thr Leu  Gly Ser Leu Ser Phe  Ser His Gly 
    4940                 4945                 4950             


Glu Gln  Arg Lys Gly Val Phe  Leu Trp Thr Phe Pro  Ser Pro Gly 
    4955                 4960                 4965             


Trp Pro  Glu Ala Phe Val Leu  His Leu Ser Gly Val  Gln Ser Ser 
    4970                 4975                 4980             


Ala Pro  Gly Gly Ala Gln Leu  Arg Ser Gly Phe Ile  Val Ala Glu 
    4985                 4990                 4995             


Ile Glu  Pro Met Gly Val Phe  Gln Phe Ser Thr Ser  Ser Arg Asn 
    5000                 5005                 5010             


Ile Ile  Val Ser Glu Asp Thr  Gln Met Ile Arg Leu  His Val Gln 
    5015                 5020                 5025             


Arg Leu  Phe Gly Phe His Ser  Asp Leu Ile Lys Val  Ser Tyr Gln 
    5030                 5035                 5040             


Thr Thr  Ala Gly Ser Ala Lys  Pro Leu Glu Asp Phe  Glu Pro Val 
    5045                 5050                 5055             


Gln Asn  Gly Glu Leu Phe Phe  Gln Lys Phe Gln Thr  Glu Val Asp 
    5060                 5065                 5070             


Phe Glu  Ile Thr Ile Ile Asn  Asp Gln Leu Ser Glu  Ile Glu Glu 
    5075                 5080                 5085             


Phe Phe  Tyr Ile Asn Leu Thr  Ser Val Glu Ile Arg  Gly Leu Gln 
    5090                 5095                 5100             


Lys Phe  Asp Val Asn Trp Ser  Pro Arg Leu Asn Leu  Asp Phe Ser 
    5105                 5110                 5115             


Val Ala  Val Ile Thr Ile Leu  Asp Asn Asp Asp Leu  Ala Gly Met 
    5120                 5125                 5130             


Asp Ile  Ser Phe Pro Glu Thr  Thr Val Ala Val Ala  Val Asp Thr 
    5135                 5140                 5145             


Thr Leu  Ile Pro Val Glu Thr  Glu Ser Thr Thr Tyr  Leu Ser Thr 
    5150                 5155                 5160             


Ser Lys  Thr Thr Thr Ile Leu  Gln Pro Thr Asn Val  Val Ala Ile 
    5165                 5170                 5175             


Val Thr  Glu Ala Thr Gly Val  Ser Ala Ile Pro Glu  Lys Leu Val 
    5180                 5185                 5190             


Thr Leu  His Gly Thr Pro Ala  Val Ser Glu Lys Pro  Asp Val Ala 
    5195                 5200                 5205             


Thr Val  Thr Ala Asn Val Ser  Ile His Gly Thr Phe  Ser Leu Gly 
    5210                 5215                 5220             


Pro Ser  Ile Val Tyr Ile Glu  Glu Glu Met Lys Asn  Gly Thr Phe 
    5225                 5230                 5235             


Asn Thr  Ala Glu Val Leu Ile  Arg Arg Thr Gly Gly  Phe Thr Gly 
    5240                 5245                 5250             


Asn Val  Ser Ile Thr Val Lys  Thr Phe Gly Glu Arg  Cys Ala Gln 
    5255                 5260                 5265             


Met Glu  Pro Asn Ala Leu Pro  Phe Arg Gly Ile Tyr  Gly Ile Ser 
    5270                 5275                 5280             


Asn Leu  Thr Trp Ala Val Glu  Glu Glu Asp Phe Glu  Glu Gln Thr 
    5285                 5290                 5295             


Leu Thr  Leu Ile Phe Leu Asp  Gly Glu Arg Glu Arg  Lys Val Ser 
    5300                 5305                 5310             


Val Gln  Ile Leu Asp Asp Asp  Glu Pro Glu Gly Gln  Glu Phe Phe 
    5315                 5320                 5325             


Tyr Val  Phe Leu Thr Asn Pro  Gln Gly Gly Ala Gln  Ile Val Glu 
    5330                 5335                 5340             


Glu Lys  Asp Asp Thr Gly Phe  Ala Ala Phe Ala Met  Val Ile Ile 
    5345                 5350                 5355             


Thr Gly  Ser Asp Leu His Asn  Gly Ile Ile Gly Phe  Ser Glu Glu 
    5360                 5365                 5370             


Ser Gln  Ser Gly Leu Glu Leu  Arg Glu Gly Ala Val  Met Arg Arg 
    5375                 5380                 5385             


Leu His  Leu Ile Val Thr Arg  Gln Pro Asn Arg Ala  Phe Glu Asp 
    5390                 5395                 5400             


Val Lys  Val Phe Trp Arg Val  Thr Leu Asn Lys Thr  Val Val Val 
    5405                 5410                 5415             


Leu Gln  Lys Asp Gly Val Asn  Leu Val Glu Glu Leu  Gln Ser Val 
    5420                 5425                 5430             


Ser Gly  Thr Thr Thr Cys Thr  Met Gly Gln Thr Lys  Cys Phe Ile 
    5435                 5440                 5445             


Ser Ile  Glu Leu Lys Pro Glu  Lys Val Pro Gln Val  Glu Val Tyr 
    5450                 5455                 5460             


Phe Phe  Val Glu Leu Tyr Glu  Ala Thr Ala Gly Ala  Ala Ile Asn 
    5465                 5470                 5475             


Asn Ser  Ala Arg Phe Ala Gln  Ile Lys Ile Leu Glu  Ser Asp Glu 
    5480                 5485                 5490             


Ser Gln  Ser Leu Val Tyr Phe  Ser Val Gly Ser Arg  Leu Ala Val 
    5495                 5500                 5505             


Ala His  Lys Lys Ala Thr Leu  Ile Ser Leu Gln Val  Ala Arg Asp 
    5510                 5515                 5520             


Ser Gly  Thr Gly Leu Met Met  Ser Val Asn Phe Ser  Thr Gln Glu 
    5525                 5530                 5535             


Leu Arg  Ser Ala Glu Thr Ile  Gly Arg Thr Ile Ile  Ser Pro Ala 
    5540                 5545                 5550             


Ile Ser  Gly Lys Asp Phe Val  Ile Thr Glu Gly Thr  Leu Val Phe 
    5555                 5560                 5565             


Glu Pro  Gly Gln Arg Ser Thr  Val Leu Asp Val Ile  Leu Thr Pro 
    5570                 5575                 5580             


Glu Thr  Gly Ser Leu Asn Ser  Phe Pro Lys Arg Phe  Gln Ile Val 
    5585                 5590                 5595             


Leu Phe  Asp Pro Lys Gly Gly  Ala Arg Ile Asp Lys  Val Tyr Gly 
    5600                 5605                 5610             


Thr Ala  Asn Ile Thr Leu Val  Ser Asp Ala Asp Ser  Gln Ala Ile 
    5615                 5620                 5625             


Trp Gly  Leu Ala Asp Gln Leu  His Gln Pro Val Asn  Asp Asp Ile 
    5630                 5635                 5640             


Leu Asn  Arg Val Leu His Thr  Ile Ser Met Lys Val  Ala Thr Glu 
    5645                 5650                 5655             


Asn Thr  Asp Glu Gln Leu Ser  Ala Met Met His Leu  Ile Glu Lys 
    5660                 5665                 5670             


Ile Thr  Thr Glu Gly Lys Ile  Gln Ala Phe Ser Val  Ala Ser Arg 
    5675                 5680                 5685             


Thr Leu  Phe Tyr Glu Ile Leu  Cys Ser Leu Ile Asn  Pro Lys Arg 
    5690                 5695                 5700             


Lys Asp  Thr Arg Gly Phe Ser  His Phe Ala Glu Val  Thr Glu Asn 
    5705                 5710                 5715             


Phe Ala  Phe Ser Leu Leu Thr  Asn Val Thr Cys Gly  Ser Pro Gly 
    5720                 5725                 5730             


Glu Lys  Ser Lys Thr Ile Leu  Asp Ser Cys Pro Tyr  Leu Ser Ile 
    5735                 5740                 5745             


Leu Ala  Leu His Trp Tyr Pro  Gln Gln Ile Asn Gly  His Lys Phe 
    5750                 5755                 5760             


Glu Gly  Lys Glu Gly Asp Tyr  Ile Arg Ile Pro Glu  Arg Leu Leu 
    5765                 5770                 5775             


Asp Val  Gln Asp Ala Glu Ile  Met Ala Gly Lys Ser  Thr Cys Lys 
    5780                 5785                 5790             


Leu Val  Gln Phe Thr Glu Tyr  Ser Ser Gln Gln Trp  Phe Ile Ser 
    5795                 5800                 5805             


Gly Asn  Asn Leu Pro Thr Leu  Lys Asn Lys Val Leu  Ser Leu Ser 
    5810                 5815                 5820             


Val Lys  Gly Gln Ser Ser Gln  Leu Leu Thr Asn Asp  Asn Glu Val 
    5825                 5830                 5835             


Leu Tyr  Arg Ile Tyr Ala Ala  Glu Pro Arg Ile Ile  Pro Gln Thr 
    5840                 5845                 5850             


Ser Leu  Cys Leu Leu Trp Asn  Gln Ala Ala Ala Ser  Trp Leu Ser 
    5855                 5860                 5865             


Asp Ser  Gln Phe Cys Lys Val  Val Glu Glu Thr Ala  Asp Tyr Val 
    5870                 5875                 5880             


Glu Cys  Ala Cys Ser His Met  Ser Val Tyr Ala Val  Tyr Ala Arg 
    5885                 5890                 5895             


Thr Asp  Asn Leu Ser Ser Tyr  Asn Glu Ala Phe Phe  Thr Ser Gly 
    5900                 5905                 5910             


Phe Ile  Cys Ile Ser Gly Leu  Cys Leu Ala Val Leu  Ser His Ile 
    5915                 5920                 5925             


Phe Cys  Ala Arg Tyr Ser Met  Phe Ala Ala Lys Leu  Leu Thr His 
    5930                 5935                 5940             


Met Met  Ala Ala Ser Leu Gly  Thr Gln Ile Leu Phe  Leu Ala Ser 
    5945                 5950                 5955             


Ala Tyr  Ala Ser Pro Gln Leu  Ala Glu Glu Ser Cys  Ser Ala Met 
    5960                 5965                 5970             


Ala Ala  Val Thr His Tyr Leu  Tyr Leu Cys Gln Phe  Ser Trp Met 
    5975                 5980                 5985             


Leu Ile  Gln Ser Val Asn Phe  Trp Tyr Val Leu Val  Met Asn Asp 
    5990                 5995                 6000             


Glu His  Thr Glu Arg Arg Tyr  Leu Leu Phe Phe Leu  Leu Ser Trp 
    6005                 6010                 6015             


Gly Leu  Pro Ala Phe Val Val  Ile Leu Leu Ile Val  Ile Leu Lys 
    6020                 6025                 6030             


Gly Ile  Tyr His Gln Ser Met  Ser Gln Ile Tyr Gly  Leu Ile His 
    6035                 6040                 6045             


Gly Asp  Leu Cys Phe Ile Pro  Asn Val Tyr Ala Ala  Leu Phe Thr 
    6050                 6055                 6060             


Ala Ala  Leu Val Pro Leu Thr  Cys Leu Val Val Val  Phe Val Val 
    6065                 6070                 6075             


Phe Ile  His Ala Tyr Gln Val  Lys Pro Gln Trp Lys  Ala Tyr Asp 
    6080                 6085                 6090             


Asp Val  Phe Arg Gly Arg Thr  Asn Ala Ala Glu Ile  Pro Leu Ile 
    6095                 6100                 6105             


Leu Tyr  Leu Phe Ala Leu Ile  Ser Val Thr Trp Leu  Trp Gly Gly 
    6110                 6115                 6120             


Leu His  Met Ala Tyr Arg His  Phe Trp Met Leu Val  Leu Phe Val 
    6125                 6130                 6135             


Ile Phe  Asn Ser Leu Gln Gly  Leu Tyr Val Phe Met  Val Tyr Phe 
    6140                 6145                 6150             


Ile Leu  His Asn Gln Met Cys  Cys Pro Met Lys Ala  Ser Tyr Thr 
    6155                 6160                 6165             


Val Glu  Met Asn Gly His Pro  Gly Pro Ser Thr Ala  Phe Phe Thr 
    6170                 6175                 6180             


Pro Gly  Ser Gly Met Pro Pro  Ala Gly Gly Glu Ile  Ser Lys Ser 
    6185                 6190                 6195             


Thr Gln  Asn Leu Ile Gly Ala  Met Glu Glu Val Pro  Pro Asp Trp 
    6200                 6205                 6210             


Glu Arg  Ala Ser Phe Gln Gln  Gly Ser Gln Ala Ser  Pro Asp Leu 
    6215                 6220                 6225             


Lys Pro  Ser Pro Gln Asn Gly  Ala Thr Phe Pro Ser  Ser Gly Gly 
    6230                 6235                 6240             


Tyr Gly  Gln Gly Ser Leu Ile  Ala Asp Glu Glu Ser  Gln Glu Phe 
    6245                 6250                 6255             


Asp Asp  Leu Ile Phe Ala Leu  Lys Thr Gly Ala Gly  Leu Ser Val 
    6260                 6265                 6270             


Ser Asp  Asn Glu Ser Gly Gln  Gly Ser Gln Glu Gly  Gly Thr Leu 
    6275                 6280                 6285             


Thr Asp  Ser Gln Ile Val Glu  Leu Arg Arg Ile Pro  Ile Ala Asp 
    6290                 6295                 6300             


Thr His  Leu 
    6305     


<210>  533
<211>  938
<212>  PRT
<213>  Homo Sapiens

<400>  533

Asn Ser Thr Met Ile Leu Ser Leu Val Leu Glu Arg Thr Gly Gly Leu 
1               5                   10                  15      


Leu Gly Glu Ile Gln Val Asn Trp Glu Thr Val Gly Pro Asn Ser Gln 
            20                  25                  30          


Glu Ala Leu Leu Pro Gln Asn Arg Asp Ile Ala Asp Pro Val Ser Gly 
        35                  40                  45              


Leu Phe Tyr Phe Gly Glu Gly Glu Gly Gly Val Arg Thr Ile Ile Leu 
    50                  55                  60                  


Thr Ile Tyr Pro His Glu Glu Ile Glu Val Glu Glu Thr Phe Ile Ile 
65                  70                  75                  80  


Lys Leu His Leu Val Lys Gly Glu Ala Lys Leu Asp Ser Arg Ala Lys 
                85                  90                  95      


Asp Val Thr Leu Thr Ile Gln Glu Phe Gly Asp Pro Asn Gly Val Val 
            100                 105                 110         


Gln Phe Ala Pro Glu Thr Leu Ser Lys Lys Thr Tyr Ser Glu Pro Leu 
        115                 120                 125             


Ala Leu Glu Gly Pro Leu Leu Ile Thr Phe Phe Val Arg Arg Val Lys 
    130                 135                 140                 


Gly Thr Phe Gly Glu Ile Met Val Tyr Trp Glu Leu Ser Ser Glu Phe 
145                 150                 155                 160 


Asp Ile Thr Glu Asp Phe Leu Ser Thr Ser Gly Phe Phe Thr Ile Ala 
                165                 170                 175     


Asp Gly Glu Ser Glu Ala Ser Phe Asp Val His Leu Leu Pro Asp Glu 
            180                 185                 190         


Val Pro Glu Ile Glu Glu Asp Tyr Val Ile Gln Leu Val Ser Val Glu 
        195                 200                 205             


Gly Gly Ala Glu Leu Asp Leu Glu Lys Ser Ile Thr Trp Phe Ser Val 
    210                 215                 220                 


Tyr Ala Asn Asp Asp Pro His Gly Val Phe Ala Leu Tyr Ser Asp Arg 
225                 230                 235                 240 


Gln Ser Ile Leu Ile Gly Gln Asn Leu Ile Arg Ser Ile Gln Ile Asn 
                245                 250                 255     


Ile Thr Arg Leu Ala Gly Thr Phe Gly Asp Val Ala Val Gly Leu Arg 
            260                 265                 270         


Ile Ser Ser Asp His Lys Glu Gln Pro Ile Val Thr Glu Asn Ala Glu 
        275                 280                 285             


Arg Gln Leu Val Val Lys Asp Gly Ala Thr Tyr Lys Val Asp Val Val 
    290                 295                 300                 


Pro Ile Lys Asn Gln Val Phe Leu Ser Leu Gly Ser Asn Phe Thr Leu 
305                 310                 315                 320 


Gln Leu Val Thr Val Met Leu Val Gly Gly Arg Phe Tyr Gly Met Pro 
                325                 330                 335     


Thr Ile Leu Gln Glu Ala Lys Ser Ala Val Leu Pro Val Ser Glu Lys 
            340                 345                 350         


Ala Ala Asn Ser Gln Val Gly Phe Glu Ser Thr Ala Phe Gln Leu Met 
        355                 360                 365             


Asn Ile Thr Ala Gly Thr Ser His Val Met Ile Ser Arg Arg Gly Thr 
    370                 375                 380                 


Tyr Gly Ala Leu Ser Val Ala Trp Thr Thr Gly Tyr Ala Pro Gly Leu 
385                 390                 395                 400 


Glu Ile Pro Glu Phe Ile Val Val Gly Asn Met Thr Pro Thr Leu Gly 
                405                 410                 415     


Ser Leu Ser Phe Ser His Gly Glu Gln Arg Lys Gly Val Phe Leu Trp 
            420                 425                 430         


Thr Phe Pro Ser Pro Gly Trp Pro Glu Ala Phe Val Leu His Leu Ser 
        435                 440                 445             


Gly Val Gln Ser Ser Ala Pro Gly Gly Ala Gln Leu Arg Ser Gly Phe 
    450                 455                 460                 


Ile Val Ala Glu Ile Glu Pro Met Gly Val Phe Gln Phe Ser Thr Ser 
465                 470                 475                 480 


Ser Arg Asn Ile Ile Val Ser Glu Asp Thr Gln Met Ile Arg Leu His 
                485                 490                 495     


Val Gln Arg Leu Phe Gly Phe His Ser Asp Leu Ile Lys Val Ser Tyr 
            500                 505                 510         


Gln Thr Thr Ala Gly Ser Ala Lys Pro Leu Glu Asp Phe Glu Pro Val 
        515                 520                 525             


Gln Asn Gly Glu Leu Phe Phe Gln Lys Phe Gln Thr Glu Val Asp Phe 
    530                 535                 540                 


Glu Ile Thr Ile Ile Asn Asp Gln Leu Ser Glu Ile Glu Glu Phe Phe 
545                 550                 555                 560 


Tyr Ile Asn Leu Thr Ser Val Glu Ile Arg Gly Leu Gln Lys Phe Asp 
                565                 570                 575     


Val Asn Trp Ser Pro Arg Leu Asn Leu Asp Phe Ser Val Ala Val Ile 
            580                 585                 590         


Thr Ile Leu Asp Asn Asp Asp Leu Ala Gly Met Asp Ile Ser Phe Pro 
        595                 600                 605             


Glu Thr Thr Val Ala Val Ala Val Asp Thr Thr Leu Ile Pro Val Glu 
    610                 615                 620                 


Thr Glu Ser Thr Thr Tyr Leu Ser Thr Ser Lys Thr Thr Thr Ile Leu 
625                 630                 635                 640 


Gln Pro Thr Asn Val Val Ala Ile Val Thr Glu Ala Thr Gly Val Ser 
                645                 650                 655     


Ala Ile Pro Glu Lys Leu Val Thr Leu His Gly Thr Pro Ala Val Ser 
            660                 665                 670         


Glu Lys Pro Asp Val Ala Thr Val Thr Ala Asn Val Ser Ile His Gly 
        675                 680                 685             


Thr Phe Ser Leu Gly Pro Ser Ile Val Tyr Ile Glu Glu Glu Met Lys 
    690                 695                 700                 


Asn Gly Thr Phe Asn Thr Ala Glu Val Leu Ile Arg Arg Thr Gly Gly 
705                 710                 715                 720 


Phe Thr Gly Asn Val Ser Ile Thr Val Lys Thr Phe Gly Glu Arg Cys 
                725                 730                 735     


Ala Gln Met Glu Pro Asn Ala Leu Pro Phe Arg Gly Ile Tyr Gly Ile 
            740                 745                 750         


Ser Asn Leu Thr Trp Ala Val Glu Glu Glu Asp Phe Glu Glu Gln Thr 
        755                 760                 765             


Leu Thr Leu Ile Phe Leu Asp Gly Glu Arg Glu Arg Lys Val Ser Val 
    770                 775                 780                 


Gln Ile Leu Asp Asp Asp Glu Pro Glu Gly Gln Glu Phe Phe Tyr Val 
785                 790                 795                 800 


Phe Leu Thr Asn Pro Gln Gly Gly Ala Gln Ile Val Glu Glu Lys Asp 
                805                 810                 815     


Asp Thr Gly Phe Ala Ala Phe Ala Met Val Ile Ile Thr Gly Ser Asp 
            820                 825                 830         


Leu His Asn Gly Ile Ile Gly Phe Ser Glu Glu Ser Gln Ser Gly Leu 
        835                 840                 845             


Glu Leu Arg Glu Gly Ala Val Met Arg Arg Leu His Leu Ile Val Thr 
    850                 855                 860                 


Arg Gln Pro Asn Arg Ala Phe Glu Asp Val Lys Val Phe Trp Arg Val 
865                 870                 875                 880 


Thr Leu Asn Lys Thr Val Val Val Leu Gln Lys Asp Gly Val Asn Leu 
                885                 890                 895     


Val Glu Glu Leu Gln Ser Val Ser Gly Thr Thr Thr Cys Thr Met Gly 
            900                 905                 910         


Gln Thr Lys Cys Phe Ile Ser Ile Glu Leu Lys Pro Glu Lys Arg Asn 
        915                 920                 925             


Ala Thr Glu Pro Ile Ile Lys Ser Phe Ser 
    930                 935             


<210>  534
<211>  2624
<212>  PRT
<213>  Homo Sapiens

<400>  534

Gln Leu Lys Asn Pro Lys Gly Gly Ala Glu Ile Gly Ile Asn Asp Ser 
1               5                   10                  15      


Val Thr Ile Thr Ile Leu Ser Asn Asp Asp Ala Tyr Gly Ile Val Ala 
            20                  25                  30          


Phe Ala Gln Asn Ser Leu Tyr Lys Gln Val Glu Glu Met Glu Gln Asp 
        35                  40                  45              


Ser Leu Val Thr Leu Asn Val Glu Arg Leu Lys Gly Thr Tyr Gly Arg 
    50                  55                  60                  


Ile Thr Ile Ala Trp Glu Ala Asp Gly Ser Ile Ser Asp Ile Phe Pro 
65                  70                  75                  80  


Thr Ser Gly Val Ile Leu Phe Thr Glu Gly Gln Val Leu Ser Thr Ile 
                85                  90                  95      


Thr Leu Thr Ile Leu Ala Asp Asn Ile Pro Glu Leu Ser Glu Val Val 
            100                 105                 110         


Ile Val Thr Leu Thr Arg Ile Thr Thr Glu Gly Val Glu Asp Ser Tyr 
        115                 120                 125             


Lys Gly Ala Thr Ile Asp Gln Asp Arg Ser Lys Ser Val Ile Thr Thr 
    130                 135                 140                 


Leu Pro Asn Asp Ser Pro Phe Gly Leu Val Gly Trp Arg Ala Ala Ser 
145                 150                 155                 160 


Val Phe Ile Arg Val Ala Glu Pro Lys Glu Asn Thr Thr Thr Leu Gln 
                165                 170                 175     


Leu Gln Ile Ala Arg Asp Lys Gly Leu Leu Gly Asp Ile Ala Ile His 
            180                 185                 190         


Leu Arg Ala Gln Pro Asn Phe Leu Leu His Val Asp Asn Gln Ala Thr 
        195                 200                 205             


Glu Asn Glu Asp Tyr Val Leu Gln Glu Thr Ile Ile Ile Met Lys Glu 
    210                 215                 220                 


Asn Ile Lys Glu Ala His Ala Glu Val Ser Ile Leu Pro Gly Ala Gly 
225                 230                 235                 240 


Glu Val Ile Thr Ala Tyr Glu Val Pro Pro Pro Leu Asn Val Leu Gln 
                245                 250                 255     


Val Pro Val Val Arg Leu Ala Gly Ser Phe Gly Ala Val Asn Val Tyr 
            260                 265                 270         


Trp Lys Ala Ser Pro Asp Ser Ala Gly Leu Glu Asp Phe Lys Pro Ser 
        275                 280                 285             


His Gly Ile Leu Glu Phe Ala Asp Lys Gln Val Thr Ala Met Ile Glu 
    290                 295                 300                 


Ile Thr Ile Ile Asp Asp Ala Glu Phe Glu Leu Thr Glu Thr Phe Asn 
305                 310                 315                 320 


Ile Ser Leu Ile Ser Val Ala Gly Gly Gly Arg Leu Gly Asp Asp Val 
                325                 330                 335     


Val Val Thr Val Val Ile Pro Gln Asn Asp Ser Pro Phe Gly Val Phe 
            340                 345                 350         


Gly Phe Glu Glu Lys Thr Val Met Ile Asp Glu Ser Leu Ser Ser Asp 
        355                 360                 365             


Asp Pro Asp Ser Tyr Val Thr Leu Thr Val Val Arg Ser Pro Gly Gly 
    370                 375                 380                 


Lys Gly Thr Val Arg Leu Glu Trp Thr Ile Asp Glu Lys Ala Lys His 
385                 390                 395                 400 


Asn Leu Ser Pro Leu Asn Gly Thr Leu His Phe Asp Glu Thr Glu Ser 
                405                 410                 415     


Gln Lys Thr Ile Val Leu His Thr Leu Gln Asp Thr Val Leu Glu Glu 
            420                 425                 430         


Asp Arg Arg Phe Thr Ile Gln Leu Ile Ser Ile Asp Glu Val Glu Ile 
        435                 440                 445             


Ser Pro Val Lys Gly Ser Ala Ser Ile Ile Ile Arg Gly Asp Lys Arg 
    450                 455                 460                 


Ala Ser Gly Glu Val Gly Ile Ala Pro Ser Ser Arg His Ile Leu Ile 
465                 470                 475                 480 


Gly Glu Pro Ser Ala Lys Tyr Asn Gly Thr Ala Ile Ile Ser Leu Val 
                485                 490                 495     


Arg Gly Pro Gly Ile Leu Gly Glu Val Thr Val Phe Trp Arg Ile Phe 
            500                 505                 510         


Pro Pro Ser Val Gly Glu Phe Ala Glu Thr Ser Gly Lys Leu Thr Met 
        515                 520                 525             


Arg Asp Glu Gln Ser Ala Val Ile Val Val Ile Gln Ala Leu Asn Asp 
    530                 535                 540                 


Asp Ile Pro Glu Glu Lys Ser Phe Tyr Glu Phe Gln Leu Thr Ala Val 
545                 550                 555                 560 


Ser Glu Gly Gly Val Leu Ser Glu Ser Ser Ser Thr Ala Asn Ile Thr 
                565                 570                 575     


Val Val Ala Ser Asp Ser Pro Tyr Gly Arg Phe Ala Phe Ser His Glu 
            580                 585                 590         


Gln Leu Arg Val Ser Glu Ala Gln Arg Val Asn Ile Thr Ile Ile Arg 
        595                 600                 605             


Ser Ser Gly Asp Phe Gly His Val Arg Leu Trp Tyr Lys Thr Met Ser 
    610                 615                 620                 


Gly Thr Ala Glu Ala Gly Leu Asp Phe Val Pro Ala Ala Gly Glu Leu 
625                 630                 635                 640 


Leu Phe Glu Ala Gly Glu Met Arg Lys Ser Leu His Val Glu Ile Leu 
                645                 650                 655     


Asp Asp Asp Tyr Pro Glu Gly Pro Glu Glu Phe Ser Leu Thr Ile Thr 
            660                 665                 670         


Lys Val Glu Leu Gln Gly Arg Gly Tyr Asp Phe Thr Ile Gln Glu Asn 
        675                 680                 685             


Gly Leu Gln Ile Asp Gln Pro Pro Glu Ile Gly Asn Ile Ser Ile Val 
    690                 695                 700                 


Arg Ile Ile Ile Met Lys Asn Asp Asn Ala Glu Gly Ile Ile Glu Phe 
705                 710                 715                 720 


Asp Pro Lys Tyr Thr Ala Phe Glu Val Glu Glu Asp Val Gly Leu Ile 
                725                 730                 735     


Met Ile Pro Val Val Arg Leu His Gly Thr Tyr Gly Tyr Val Thr Ala 
            740                 745                 750         


Asp Phe Ile Ser Gln Ser Ser Ser Ala Ser Pro Gly Gly Val Asp Tyr 
        755                 760                 765             


Ile Leu His Gly Ser Thr Val Thr Phe Gln His Gly Gln Asn Leu Ser 
    770                 775                 780                 


Phe Ile Asn Ile Ser Ile Ile Asp Asp Asn Glu Ser Glu Phe Glu Glu 
785                 790                 795                 800 


Pro Ile Glu Ile Leu Leu Thr Gly Ala Thr Gly Gly Ala Val Leu Gly 
                805                 810                 815     


Arg His Leu Val Ser Arg Ile Ile Ile Ala Lys Ser Asp Ser Pro Phe 
            820                 825                 830         


Gly Val Ile Arg Phe Leu Asn Gln Ser Lys Ile Ser Ile Ala Asn Pro 
        835                 840                 845             


Asn Ser Thr Met Ile Leu Ser Leu Val Leu Glu Arg Thr Gly Gly Leu 
    850                 855                 860                 


Leu Gly Glu Ile Gln Val Asn Trp Glu Thr Val Gly Pro Asn Ser Gln 
865                 870                 875                 880 


Glu Ala Leu Leu Pro Gln Asn Arg Asp Ile Ala Asp Pro Val Ser Gly 
                885                 890                 895     


Leu Phe Tyr Phe Gly Glu Gly Glu Gly Gly Val Arg Thr Ile Ile Leu 
            900                 905                 910         


Thr Ile Tyr Pro His Glu Glu Ile Glu Val Glu Glu Thr Phe Ile Ile 
        915                 920                 925             


Lys Leu His Leu Val Lys Gly Glu Ala Lys Leu Asp Ser Arg Ala Lys 
    930                 935                 940                 


Asp Val Thr Leu Thr Ile Gln Glu Phe Gly Asp Pro Asn Gly Val Val 
945                 950                 955                 960 


Gln Phe Ala Pro Glu Thr Leu Ser Lys Lys Thr Tyr Ser Glu Pro Leu 
                965                 970                 975     


Ala Leu Glu Gly Pro Leu Leu Ile Thr Phe Phe Val Arg Arg Val Lys 
            980                 985                 990         


Gly Thr Phe Gly Glu Ile Met Val  Tyr Trp Glu Leu Ser  Ser Glu Phe 
        995                 1000                 1005             


Asp Ile  Thr Glu Asp Phe Leu  Ser Thr Ser Gly Phe  Phe Thr Ile 
    1010                 1015                 1020             


Ala Asp  Gly Glu Ser Glu Ala  Ser Phe Asp Val His  Leu Leu Pro 
    1025                 1030                 1035             


Asp Glu  Val Pro Glu Ile Glu  Glu Asp Tyr Val Ile  Gln Leu Val 
    1040                 1045                 1050             


Ser Val  Glu Gly Gly Ala Glu  Leu Asp Leu Glu Lys  Ser Ile Thr 
    1055                 1060                 1065             


Trp Phe  Ser Val Tyr Ala Asn  Asp Asp Pro His Gly  Val Phe Ala 
    1070                 1075                 1080             


Leu Tyr  Ser Asp Arg Gln Ser  Ile Leu Ile Gly Gln  Asn Leu Ile 
    1085                 1090                 1095             


Arg Ser  Ile Gln Ile Asn Ile  Thr Arg Leu Ala Gly  Thr Phe Gly 
    1100                 1105                 1110             


Asp Val  Ala Val Gly Leu Arg  Ile Ser Ser Asp His  Lys Glu Gln 
    1115                 1120                 1125             


Pro Ile  Val Thr Glu Asn Ala  Glu Arg Gln Leu Val  Val Lys Asp 
    1130                 1135                 1140             


Gly Ala  Thr Tyr Lys Val Asp  Val Val Pro Ile Lys  Asn Gln Val 
    1145                 1150                 1155             


Phe Leu  Ser Leu Gly Ser Asn  Phe Thr Leu Gln Leu  Val Thr Val 
    1160                 1165                 1170             


Met Leu  Val Gly Gly Arg Phe  Tyr Gly Met Pro Thr  Ile Leu Gln 
    1175                 1180                 1185             


Glu Ala  Lys Ser Ala Val Leu  Pro Val Ser Glu Lys  Ala Ala Asn 
    1190                 1195                 1200             


Ser Gln  Val Gly Phe Glu Ser  Thr Ala Phe Gln Leu  Met Asn Ile 
    1205                 1210                 1215             


Thr Ala  Gly Thr Ser His Val  Met Ile Ser Arg Arg  Gly Thr Tyr 
    1220                 1225                 1230             


Gly Ala  Leu Ser Val Ala Trp  Thr Thr Gly Tyr Ala  Pro Gly Leu 
    1235                 1240                 1245             


Glu Ile  Pro Glu Phe Ile Val  Val Gly Asn Met Thr  Pro Thr Leu 
    1250                 1255                 1260             


Gly Ser  Leu Ser Phe Ser His  Gly Glu Gln Arg Lys  Gly Val Phe 
    1265                 1270                 1275             


Leu Trp  Thr Phe Pro Ser Pro  Gly Trp Pro Glu Ala  Phe Val Leu 
    1280                 1285                 1290             


His Leu  Ser Gly Val Gln Ser  Ser Ala Pro Gly Gly  Ala Gln Leu 
    1295                 1300                 1305             


Arg Ser  Gly Phe Ile Val Ala  Glu Ile Glu Pro Met  Gly Val Phe 
    1310                 1315                 1320             


Gln Phe  Ser Thr Ser Ser Arg  Asn Ile Ile Val Ser  Glu Asp Thr 
    1325                 1330                 1335             


Gln Met  Ile Arg Leu His Val  Gln Arg Leu Phe Gly  Phe His Ser 
    1340                 1345                 1350             


Asp Leu  Ile Lys Val Ser Tyr  Gln Thr Thr Ala Gly  Ser Ala Lys 
    1355                 1360                 1365             


Pro Leu  Glu Asp Phe Glu Pro  Val Gln Asn Gly Glu  Leu Phe Phe 
    1370                 1375                 1380             


Gln Lys  Phe Gln Thr Glu Val  Asp Phe Glu Ile Thr  Ile Ile Asn 
    1385                 1390                 1395             


Asp Gln  Leu Ser Glu Ile Glu  Glu Phe Phe Tyr Ile  Asn Leu Thr 
    1400                 1405                 1410             


Ser Val  Glu Ile Arg Gly Leu  Gln Lys Phe Asp Val  Asn Trp Ser 
    1415                 1420                 1425             


Pro Arg  Leu Asn Leu Asp Phe  Ser Val Ala Val Ile  Thr Ile Leu 
    1430                 1435                 1440             


Asp Asn  Asp Asp Leu Ala Gly  Met Asp Ile Ser Phe  Pro Glu Thr 
    1445                 1450                 1455             


Thr Val  Ala Val Ala Val Asp  Thr Thr Leu Ile Pro  Val Glu Thr 
    1460                 1465                 1470             


Glu Ser  Thr Thr Tyr Leu Ser  Thr Ser Lys Thr Thr  Thr Ile Leu 
    1475                 1480                 1485             


Gln Pro  Thr Asn Val Val Ala  Ile Val Thr Glu Ala  Thr Gly Val 
    1490                 1495                 1500             


Ser Ala  Ile Pro Glu Lys Leu  Val Thr Leu His Gly  Thr Pro Ala 
    1505                 1510                 1515             


Val Ser  Glu Lys Pro Asp Val  Ala Thr Val Thr Ala  Asn Val Ser 
    1520                 1525                 1530             


Ile His  Gly Thr Phe Ser Leu  Gly Pro Ser Ile Val  Tyr Ile Glu 
    1535                 1540                 1545             


Glu Glu  Met Lys Asn Gly Thr  Phe Asn Thr Ala Glu  Val Leu Ile 
    1550                 1555                 1560             


Arg Arg  Thr Gly Gly Phe Thr  Gly Asn Val Ser Ile  Thr Val Lys 
    1565                 1570                 1575             


Thr Phe  Gly Glu Arg Cys Ala  Gln Met Glu Pro Asn  Ala Leu Pro 
    1580                 1585                 1590             


Phe Arg  Gly Ile Tyr Gly Ile  Ser Asn Leu Thr Trp  Ala Val Glu 
    1595                 1600                 1605             


Glu Glu  Asp Phe Glu Glu Gln  Thr Leu Thr Leu Ile  Phe Leu Asp 
    1610                 1615                 1620             


Gly Glu  Arg Glu Arg Lys Val  Ser Val Gln Ile Leu  Asp Asp Asp 
    1625                 1630                 1635             


Glu Pro  Glu Gly Gln Glu Phe  Phe Tyr Val Phe Leu  Thr Asn Pro 
    1640                 1645                 1650             


Gln Gly  Gly Ala Gln Ile Val  Glu Glu Lys Asp Asp  Thr Gly Phe 
    1655                 1660                 1665             


Ala Ala  Phe Ala Met Val Ile  Ile Thr Gly Ser Asp  Leu His Asn 
    1670                 1675                 1680             


Gly Ile  Ile Gly Phe Ser Glu  Glu Ser Gln Ser Gly  Leu Glu Leu 
    1685                 1690                 1695             


Arg Glu  Gly Ala Val Met Arg  Arg Leu His Leu Ile  Val Thr Arg 
    1700                 1705                 1710             


Gln Pro  Asn Arg Ala Phe Glu  Asp Val Lys Val Phe  Trp Arg Val 
    1715                 1720                 1725             


Thr Leu  Asn Lys Thr Val Val  Val Leu Gln Lys Asp  Gly Val Asn 
    1730                 1735                 1740             


Leu Val  Glu Glu Leu Gln Ser  Val Ser Gly Thr Thr  Thr Cys Thr 
    1745                 1750                 1755             


Met Gly  Gln Thr Lys Cys Phe  Ile Ser Ile Glu Leu  Lys Pro Glu 
    1760                 1765                 1770             


Lys Val  Pro Gln Val Glu Val  Tyr Phe Phe Val Glu  Leu Tyr Glu 
    1775                 1780                 1785             


Ala Thr  Ala Gly Ala Ala Ile  Asn Asn Ser Ala Arg  Phe Ala Gln 
    1790                 1795                 1800             


Ile Lys  Ile Leu Glu Ser Asp  Glu Ser Gln Ser Leu  Val Tyr Phe 
    1805                 1810                 1815             


Ser Val  Gly Ser Arg Leu Ala  Val Ala His Lys Lys  Ala Thr Leu 
    1820                 1825                 1830             


Ile Ser  Leu Gln Val Ala Arg  Asp Ser Gly Thr Gly  Leu Met Met 
    1835                 1840                 1845             


Ser Val  Asn Phe Ser Thr Gln  Glu Leu Arg Ser Ala  Glu Thr Ile 
    1850                 1855                 1860             


Gly Arg  Thr Ile Ile Ser Pro  Ala Ile Ser Gly Lys  Asp Phe Val 
    1865                 1870                 1875             


Ile Thr  Glu Gly Thr Leu Val  Phe Glu Pro Gly Gln  Arg Ser Thr 
    1880                 1885                 1890             


Val Leu  Asp Val Ile Leu Thr  Pro Glu Thr Gly Ser  Leu Asn Ser 
    1895                 1900                 1905             


Phe Pro  Lys Arg Phe Gln Ile  Val Leu Phe Asp Pro  Lys Gly Gly 
    1910                 1915                 1920             


Ala Arg  Ile Asp Lys Val Tyr  Gly Thr Ala Asn Ile  Thr Leu Val 
    1925                 1930                 1935             


Ser Asp  Ala Asp Ser Gln Ala  Ile Trp Gly Leu Ala  Asp Gln Leu 
    1940                 1945                 1950             


His Gln  Pro Val Asn Asp Asp  Ile Leu Asn Arg Val  Leu His Thr 
    1955                 1960                 1965             


Ile Ser  Met Lys Val Ala Thr  Glu Asn Thr Asp Glu  Gln Leu Ser 
    1970                 1975                 1980             


Ala Met  Met His Leu Ile Glu  Lys Ile Thr Thr Glu  Gly Lys Ile 
    1985                 1990                 1995             


Gln Ala  Phe Ser Val Ala Ser  Arg Thr Leu Phe Tyr  Glu Ile Leu 
    2000                 2005                 2010             


Cys Ser  Leu Ile Asn Pro Lys  Arg Lys Asp Thr Arg  Gly Phe Ser 
    2015                 2020                 2025             


His Phe  Ala Glu Val Thr Glu  Asn Phe Ala Phe Ser  Leu Leu Thr 
    2030                 2035                 2040             


Asn Val  Thr Cys Gly Ser Pro  Gly Glu Lys Ser Lys  Thr Ile Leu 
    2045                 2050                 2055             


Asp Ser  Cys Pro Tyr Leu Ser  Ile Leu Ala Leu His  Trp Tyr Pro 
    2060                 2065                 2070             


Gln Gln  Ile Asn Gly His Lys  Phe Glu Gly Lys Glu  Gly Asp Tyr 
    2075                 2080                 2085             


Ile Arg  Ile Pro Glu Arg Leu  Leu Asp Val Gln Asp  Ala Glu Ile 
    2090                 2095                 2100             


Met Ala  Gly Lys Ser Thr Cys  Lys Leu Val Gln Phe  Thr Glu Tyr 
    2105                 2110                 2115             


Ser Ser  Gln Gln Trp Phe Ile  Ser Gly Asn Asn Leu  Pro Thr Leu 
    2120                 2125                 2130             


Lys Asn  Lys Val Leu Ser Leu  Ser Val Lys Gly Gln  Ser Ser Gln 
    2135                 2140                 2145             


Leu Leu  Thr Asn Asp Asn Glu  Val Leu Tyr Arg Ile  Tyr Ala Ala 
    2150                 2155                 2160             


Glu Pro  Arg Ile Ile Pro Gln  Thr Ser Leu Cys Leu  Leu Trp Asn 
    2165                 2170                 2175             


Gln Ala  Ala Ala Ser Trp Leu  Ser Asp Ser Gln Phe  Cys Lys Val 
    2180                 2185                 2190             


Val Glu  Glu Thr Ala Asp Tyr  Val Glu Cys Ala Cys  Ser His Met 
    2195                 2200                 2205             


Ser Val  Tyr Ala Val Tyr Ala  Arg Thr Asp Asn Leu  Ser Ser Tyr 
    2210                 2215                 2220             


Asn Glu  Ala Phe Phe Thr Ser  Gly Phe Ile Cys Ile  Ser Gly Leu 
    2225                 2230                 2235             


Cys Leu  Ala Val Leu Ser His  Ile Phe Cys Ala Arg  Tyr Ser Met 
    2240                 2245                 2250             


Phe Ala  Ala Lys Leu Leu Thr  His Met Met Ala Ala  Ser Leu Gly 
    2255                 2260                 2265             


Thr Gln  Ile Leu Phe Leu Ala  Ser Ala Tyr Ala Ser  Pro Gln Leu 
    2270                 2275                 2280             


Ala Glu  Glu Ser Cys Ser Ala  Met Ala Ala Val Thr  His Tyr Leu 
    2285                 2290                 2295             


Tyr Leu  Cys Gln Phe Ser Trp  Met Leu Ile Gln Ser  Val Asn Phe 
    2300                 2305                 2310             


Trp Tyr  Val Leu Val Met Asn  Asp Glu His Thr Glu  Arg Arg Tyr 
    2315                 2320                 2325             


Leu Leu  Phe Phe Leu Leu Ser  Trp Gly Leu Pro Ala  Phe Val Val 
    2330                 2335                 2340             


Ile Leu  Leu Ile Val Ile Leu  Lys Gly Ile Tyr His  Gln Ser Met 
    2345                 2350                 2355             


Ser Gln  Ile Tyr Gly Leu Ile  His Gly Asp Leu Cys  Phe Ile Pro 
    2360                 2365                 2370             


Asn Val  Tyr Ala Ala Leu Phe  Thr Ala Ala Leu Val  Pro Leu Thr 
    2375                 2380                 2385             


Cys Leu  Val Val Val Phe Val  Val Phe Ile His Ala  Tyr Gln Val 
    2390                 2395                 2400             


Lys Pro  Gln Trp Lys Ala Tyr  Asp Asp Val Phe Arg  Gly Arg Thr 
    2405                 2410                 2415             


Asn Ala  Ala Glu Ile Pro Leu  Ile Leu Tyr Leu Phe  Ala Leu Ile 
    2420                 2425                 2430             


Ser Val  Thr Trp Leu Trp Gly  Gly Leu His Met Ala  Tyr Arg His 
    2435                 2440                 2445             


Phe Trp  Met Leu Val Leu Phe  Val Ile Phe Asn Ser  Leu Gln Gly 
    2450                 2455                 2460             


Leu Tyr  Val Phe Met Val Tyr  Phe Ile Leu His Asn  Gln Met Cys 
    2465                 2470                 2475             


Cys Pro  Met Lys Ala Ser Tyr  Thr Val Glu Met Asn  Gly His Pro 
    2480                 2485                 2490             


Gly Pro  Ser Thr Ala Phe Phe  Thr Pro Gly Ser Gly  Met Pro Pro 
    2495                 2500                 2505             


Ala Gly  Gly Glu Ile Ser Lys  Ser Thr Gln Asn Leu  Ile Gly Ala 
    2510                 2515                 2520             


Met Glu  Glu Val Pro Pro Asp  Trp Glu Arg Ala Ser  Phe Gln Gln 
    2525                 2530                 2535             


Gly Ser  Gln Ala Ser Pro Asp  Leu Lys Pro Ser Pro  Gln Asn Gly 
    2540                 2545                 2550             


Ala Thr  Phe Pro Ser Ser Gly  Gly Tyr Gly Gln Gly  Ser Leu Ile 
    2555                 2560                 2565             


Ala Asp  Glu Glu Ser Gln Glu  Phe Asp Asp Leu Ile  Phe Ala Leu 
    2570                 2575                 2580             


Lys Thr  Gly Ala Gly Leu Ser  Val Ser Asp Asn Glu  Ser Gly Gln 
    2585                 2590                 2595             


Gly Ser  Gln Glu Gly Gly Thr  Leu Thr Asp Ser Gln  Ile Val Glu 
    2600                 2605                 2610             


Leu Arg  Arg Ile Pro Ile Ala  Asp Thr His Leu 
    2615                 2620                 


<210>  535
<211>  390
<212>  PRT
<213>  Homo Sapiens

<400>  535

Thr Phe Gln His Gly Gln Asn Leu Ser Phe Ile Asn Ile Ser Ile Ile 
1               5                   10                  15      


Asp Asp Asn Glu Ser Glu Phe Glu Glu Pro Ile Glu Ile Leu Leu Thr 
            20                  25                  30          


Gly Ala Thr Gly Gly Ala Val Leu Gly Arg His Leu Val Ser Arg Ile 
        35                  40                  45              


Ile Ile Ala Lys Ser Asp Ser Pro Phe Gly Val Ile Arg Phe Leu Asn 
    50                  55                  60                  


Gln Ser Lys Ile Ser Ile Ala Asn Pro Asn Ser Thr Met Ile Leu Ser 
65                  70                  75                  80  


Leu Val Leu Glu Arg Thr Gly Gly Leu Leu Gly Glu Ile Gln Val Asn 
                85                  90                  95      


Trp Glu Thr Val Gly Pro Asn Ser Gln Glu Ala Leu Leu Pro Gln Asn 
            100                 105                 110         


Arg Asp Ile Ala Asp Pro Val Ser Gly Leu Phe Tyr Phe Gly Glu Gly 
        115                 120                 125             


Glu Gly Gly Val Arg Thr Ile Ile Leu Thr Ile Tyr Pro His Glu Glu 
    130                 135                 140                 


Ile Glu Val Glu Glu Thr Phe Ile Ile Lys Leu His Leu Val Lys Gly 
145                 150                 155                 160 


Glu Ala Lys Leu Asp Ser Arg Ala Lys Asp Val Thr Leu Thr Ile Gln 
                165                 170                 175     


Glu Phe Gly Asp Pro Asn Gly Val Val Gln Phe Ala Pro Glu Thr Leu 
            180                 185                 190         


Ser Lys Lys Thr Tyr Ser Glu Pro Leu Ala Leu Glu Gly Pro Leu Leu 
        195                 200                 205             


Ile Thr Phe Phe Val Arg Arg Val Lys Gly Thr Phe Gly Glu Ile Met 
    210                 215                 220                 


Val Tyr Trp Glu Leu Ser Ser Glu Phe Asp Ile Thr Glu Asp Phe Leu 
225                 230                 235                 240 


Ser Thr Ser Gly Phe Phe Thr Ile Ala Asp Gly Glu Ser Glu Ala Ser 
                245                 250                 255     


Phe Asp Val His Leu Leu Pro Asp Glu Val Pro Glu Ile Glu Glu Asp 
            260                 265                 270         


Tyr Val Ile Gln Leu Val Ser Val Glu Gly Gly Ala Glu Leu Asp Leu 
        275                 280                 285             


Glu Lys Ser Ile Thr Trp Phe Ser Val Tyr Ala Asn Asp Asp Pro His 
    290                 295                 300                 


Gly Val Phe Ala Leu Tyr Ser Asp Arg Gln Ser Ile Leu Ile Gly Gln 
305                 310                 315                 320 


Asn Leu Ile Arg Ser Ile Gln Ile Asn Ile Thr Arg Leu Ala Gly Thr 
                325                 330                 335     


Phe Gly Asp Val Ala Val Gly Leu Arg Ile Ser Ser Asp His Lys Glu 
            340                 345                 350         


Gln Pro Ile Val Thr Glu Asn Ala Glu Arg Gln Leu Val Val Lys Asp 
        355                 360                 365             


Gly Ala Thr Tyr Lys Val Asp Val Val Pro Ile Lys Asn Gln Val Cys 
    370                 375                 380                 


Gly Ile Ser Ser Val Ser 
385                 390 


<210>  536
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  536

Val Pro His Ile Thr Val Glu Glu Glu Asp Gly Glu Ile Arg Leu Leu 
1               5                   10                  15      


Val Ile Arg Ala Gln Gly Leu Leu Gly Arg Val Thr Ala Glu Phe Arg 
            20                  25                  30          


Thr Val Ser Leu Thr Ala Phe Ser Pro Glu Asp Tyr Gln Asn Val Ala 
        35                  40                  45              


Gly Thr Leu Glu Phe Gln Pro Gly Glu Arg Tyr Lys Tyr Ile Phe Ile 
    50                  55                  60                  


Asn Ile Thr Asp Asn Ser Ile Pro Glu Leu Glu Lys Ser Phe Lys Val 
65                  70                  75                  80  


Glu Leu Leu Asn Leu Glu Gly Gly Val Cys Glu Phe Leu Val Arg Ala 
                85                  90                  95      


Gly Asp Glu 
            


<210>  537
<211>  80
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  537

Xaa Asp Glu Gln Leu Ser Ala Met Met His Leu Ile Glu Lys Ile Thr 
1               5                   10                  15      


Thr Glu Gly Lys Ile Gln Ala Phe Ser Val Ala Ser Arg Thr Leu Phe 
            20                  25                  30          


Tyr Glu Ile Leu Cys Ser Leu Ile Asn Pro Lys Arg Lys Asp Thr Arg 
        35                  40                  45              


Gly Phe Ser His Phe Ala Glu Val Thr Glu Asn Phe Ala Phe Ser Leu 
    50                  55                  60                  


Leu Thr Asn Val Thr Cys Gly Ser Pro Gly Glu Lys Ser Pro Ala Cys 
65                  70                  75                  80  


<210>  538
<211>  72
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  538

Xaa Glu Gly Ser Thr Ile Ser Cys Val Val Glu Arg Thr Arg Gly Ala 
1               5                   10                  15      


Leu Asp Tyr Val His Val Phe Tyr Thr Ile Ser Gln Ile Glu Thr Asp 
            20                  25                  30          


Gly Ile Asn Tyr Leu Val Asp Asp Phe Ala Asn Ala Ser Gly Thr Ile 
        35                  40                  45              


Thr Phe Leu Pro Trp Gln Arg Ser Glu Leu Leu Ile Glu Val Ser Leu 
    50                  55                  60                  


Pro Ile Ile Ile Tyr Asn Cys Asn 
65                  70          


<210>  539
<211>  567
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  539

Xaa Ile Thr Val Glu Glu Glu Asp Gly Glu Ile Arg Leu Leu Val Ile 
1               5                   10                  15      


Arg Ala Gln Gly Leu Leu Gly Arg Val Thr Ala Glu Phe Arg Thr Val 
            20                  25                  30          


Ser Leu Thr Ala Phe Ser Pro Glu Asp Tyr Gln Asn Val Ala Gly Thr 
        35                  40                  45              


Leu Glu Phe Gln Pro Gly Glu Arg Tyr Lys Tyr Ile Phe Ile Asn Ile 
    50                  55                  60                  


Thr Asp Asn Ser Ile Pro Glu Leu Glu Lys Ser Phe Lys Val Glu Leu 
65                  70                  75                  80  


Leu Asn Leu Glu Gly Gly Ala Glu Leu Phe Arg Val Asp Gly Ser Gly 
                85                  90                  95      


Ser Gly Asp Gly Asp Met Glu Phe Phe Leu Pro Thr Ile His Lys Arg 
            100                 105                 110         


Ala Ser Leu Gly Val Ala Ser Gln Ile Leu Val Thr Ile Ala Ala Ser 
        115                 120                 125             


Asp His Ala His Gly Val Phe Glu Phe Ser Pro Glu Ser Leu Phe Val 
    130                 135                 140                 


Ser Gly Thr Glu Pro Glu Asp Gly Tyr Ser Thr Val Thr Leu Asn Val 
145                 150                 155                 160 


Ile Arg His His Gly Thr Leu Ser Pro Val Thr Leu His Trp Asn Ile 
                165                 170                 175     


Asp Ser Asp Pro Asp Gly Asp Leu Ala Phe Thr Ser Gly Asn Ile Thr 
            180                 185                 190         


Phe Glu Ile Gly Gln Thr Ser Ala Asn Ile Thr Val Glu Ile Leu Pro 
        195                 200                 205             


Asp Glu Asp Pro Glu Leu Asp Lys Ala Phe Ser Val Ser Val Leu Ser 
    210                 215                 220                 


Val Ser Ser Gly Ser Leu Gly Ala His Ile Asn Ala Thr Leu Thr Val 
225                 230                 235                 240 


Leu Ala Ser Asp Asp Pro Tyr Gly Ile Phe Ile Phe Ser Glu Lys Asn 
                245                 250                 255     


Arg Pro Val Lys Val Glu Glu Ala Thr Gln Asn Ile Thr Leu Ser Ile 
            260                 265                 270         


Ile Arg Leu Lys Gly Leu Met Gly Lys Val Leu Val Ser Tyr Ala Thr 
        275                 280                 285             


Leu Asp Asp Met Glu Lys Pro Pro Tyr Phe Pro Pro Asn Leu Ala Arg 
    290                 295                 300                 


Ala Thr Gln Gly Arg Asp Tyr Ile Pro Ala Ser Gly Phe Ala Leu Phe 
305                 310                 315                 320 


Gly Ala Asn Gln Ser Glu Ala Thr Ile Ala Ile Ser Ile Leu Asp Asp 
                325                 330                 335     


Asp Glu Pro Glu Arg Ser Glu Ser Val Phe Ile Glu Leu Leu Asn Ser 
            340                 345                 350         


Thr Leu Val Ala Lys Val Gln Ser Arg Ser Ile Pro Asn Ser Pro Arg 
        355                 360                 365             


Leu Gly Pro Lys Val Glu Thr Ile Ala Gln Leu Ile Ile Ile Ala Asn 
    370                 375                 380                 


Asp Asp Ala Phe Gly Thr Leu Gln Leu Ser Ala Pro Ile Val Arg Val 
385                 390                 395                 400 


Ala Glu Asn His Val Gly Pro Ile Ile Asn Val Thr Arg Thr Gly Gly 
                405                 410                 415     


Ala Phe Ala Asp Val Ser Val Lys Phe Lys Ala Val Pro Ile Thr Ala 
            420                 425                 430         


Ile Ala Gly Glu Asp Tyr Ser Ile Ala Ser Ser Asp Val Val Leu Leu 
        435                 440                 445             


Glu Gly Glu Thr Ser Lys Ala Val Pro Ile Tyr Val Ile Asn Asp Ile 
    450                 455                 460                 


Tyr Pro Glu Leu Glu Glu Ser Phe Leu Val Gln Leu Met Asn Glu Thr 
465                 470                 475                 480 


Thr Gly Gly Ala Arg Leu Gly Ala Leu Thr Glu Ala Val Ile Ile Ile 
                485                 490                 495     


Glu Ala Ser Asp Asp Pro Tyr Gly Leu Phe Gly Phe Gln Ile Thr Lys 
            500                 505                 510         


Leu Ile Val Glu Glu Pro Glu Phe Asn Ser Val Lys Val Asn Leu Pro 
        515                 520                 525             


Ile Ile Arg Asn Ser Gly Thr Leu Gly Asn Val Thr Val Gln Trp Val 
    530                 535                 540                 


Ala Thr Ile Asn Gly Gln Leu Ala Thr Gly Asp Leu Arg Val Val Ser 
545                 550                 555                 560 


Gly Tyr Pro Ser Ala Thr Asn 
                565         


<210>  540
<211>  65
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  540

Xaa Leu Pro Thr Ile His Lys Arg Ala Ser Leu Gly Val Ala Ser Gln 
1               5                   10                  15      


Ile Leu Val Thr Ile Ala Ala Ser Asp His Ala His Gly Val Phe Glu 
            20                  25                  30          


Phe Ser Pro Glu Ser Leu Phe Val Ser Gly Thr Glu Pro Glu Asp Gly 
        35                  40                  45              


Tyr Ser Thr Val Thr Leu Asn Phe Gln Ile Leu His Val Leu Gly Leu 
    50                  55                  60                  


Arg 
65  


<210>  541
<211>  173
<212>  PRT
<213>  Homo Sapiens

<400>  541

Met Ser Val Lys Ser Ser Lys Leu Met Phe Leu Cys His Gly Ser Ser 
1               5                   10                  15      


Arg Ser Leu His Ser Gly Ser Leu Thr Ser Cys Asn Thr Gly Val Cys 
            20                  25                  30          


Cys Ser Leu Asp Ala Asp Lys Tyr Glu Asn Asp Pro Glu Leu Glu Lys 
        35                  40                  45              


Ile Arg Arg Glu Arg Asn Tyr Ser Trp Met Asp Ile Ile Thr Ile Cys 
    50                  55                  60                  


Lys Asp Lys Leu Pro Asn Tyr Glu Glu Lys Ile Lys Met Phe Tyr Glu 
65                  70                  75                  80  


Glu His Leu His Leu Asp Asp Glu Ile Arg Tyr Ile Leu Asp Gly Ser 
                85                  90                  95      


Gly Tyr Phe Asp Val Arg Asp Lys Glu Asp Gln Trp Ile Arg Ile Phe 
            100                 105                 110         


Met Glu Lys Gly Asp Met Val Thr Leu Pro Ala Gly Ile Tyr His Arg 
        115                 120                 125             


Phe Thr Val Asp Glu Lys Asn Tyr Thr Lys Ala Met Arg Leu Phe Val 
    130                 135                 140                 


Gly Glu Pro Val Trp Thr Ala Tyr Asn Arg Pro Ala Asp His Phe Glu 
145                 150                 155                 160 


Ala Arg Gly Gln Tyr Val Lys Phe Leu Ala Gln Thr Ala 
                165                 170             


<210>  542
<211>  179
<212>  PRT
<213>  Homo Sapiens

<400>  542

Met Val Gln Ala Trp Tyr Met Asp Asp Ala Pro Gly Asp Pro Arg Gln 
1               5                   10                  15      


Pro His Arg Pro Asp Pro Gly Arg Pro Val Gly Leu Glu Gln Leu Arg 
            20                  25                  30          


Arg Leu Gly Val Leu Tyr Trp Lys Leu Asp Ala Asp Lys Tyr Glu Asn 
        35                  40                  45              


Asp Pro Glu Leu Glu Lys Ile Arg Arg Glu Arg Asn Tyr Ser Trp Met 
    50                  55                  60                  


Asp Ile Ile Thr Ile Cys Lys Asp Lys Leu Pro Asn Tyr Glu Glu Lys 
65                  70                  75                  80  


Ile Lys Met Phe Tyr Glu Glu His Leu His Leu Asp Asp Glu Ile Arg 
                85                  90                  95      


Tyr Ile Leu Asp Gly Ser Gly Tyr Phe Asp Val Arg Asp Lys Glu Asp 
            100                 105                 110         


Gln Trp Ile Arg Ile Phe Met Glu Lys Gly Asp Met Val Thr Leu Pro 
        115                 120                 125             


Ala Gly Ile Tyr His Arg Phe Thr Val Asp Glu Lys Asn Tyr Thr Lys 
    130                 135                 140                 


Ala Met Arg Leu Phe Val Gly Glu Pro Val Trp Thr Ala Tyr Asn Arg 
145                 150                 155                 160 


Pro Ala Asp His Phe Glu Ala Arg Gly Gln Tyr Val Lys Phe Leu Ala 
                165                 170                 175     


Gln Thr Ala 
            


<210>  543
<211>  117
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  543

Xaa Arg Trp Glu Cys Cys Ala Phe Ser Pro Gly Pro Ala Cys Val Val 
1               5                   10                  15      


Ala Leu Ala Val Ala Ser Leu Pro Leu Asn Cys Ala Ala Ser Ala Asp 
            20                  25                  30          


Ser Lys Arg Gly Arg Trp Ala Arg Asp Ser Ser Thr Cys Ala Ser Arg 
        35                  40                  45              


Arg Val Cys Gly Ala Ala Gly Asp Val Arg Gly Asp Ser Cys Pro Ser 
    50                  55                  60                  


Val Ala Ala Ser Val Ala Pro Ala Cys Asp Pro Gly Gly Gln Asn Tyr 
65                  70                  75                  80  


Thr Lys Ala Met Arg Leu Phe Val Gly Glu Pro Val Trp Thr Ala Tyr 
                85                  90                  95      


Asn Arg Pro Ala Asp His Phe Glu Ala Arg Gly Gln Tyr Val Lys Phe 
            100                 105                 110         


Leu Ala Gln Thr Ala 
        115         


<210>  544
<211>  59
<212>  PRT
<213>  Homo Sapiens

<400>  544

Met Lys Tyr Pro Leu Met Pro Leu Val Asn Asp Leu Thr Phe Ser Phe 
1               5                   10                  15      


Leu Val Phe Trp Phe Cys Leu Pro Val Gly Leu Leu Leu Leu Leu Ile 
            20                  25                  30          


Ile Trp Leu Arg Phe Leu Leu Ser Gln Asp Ile Leu Gln Val Arg Arg 
        35                  40                  45              


Tyr Arg Tyr Asp Ala Asn Ile Leu Thr Ala Ser 
    50                  55                  


<210>  545
<211>  80
<212>  PRT
<213>  Homo Sapiens

<400>  545

Met Lys Tyr Pro Leu Met Pro Leu Val Asn Asp Leu Thr Phe Ser Phe 
1               5                   10                  15      


Leu Val Phe Trp Phe Cys Leu Pro Val Gly Leu Leu Leu Leu Leu Ile 
            20                  25                  30          


Ile Trp Leu Arg Phe Leu Leu Ser Gln Asp Ser Glu Glu Asn Asp Ser 
        35                  40                  45              


Ser Val Cys Leu Asp Trp Glu Pro Trp Ser Lys Gly Pro Ala Glu Phe 
    50                  55                  60                  


Cys Trp Lys Gly Thr Leu His Gly Gln Glu Lys Glu Arg Pro Cys Trp 
65                  70                  75                  80  


<210>  546
<211>  80
<212>  PRT
<213>  Homo Sapiens

<400>  546

Met Lys Tyr Pro Leu Met Pro Leu Val Asn Asp Leu Thr Phe Ser Phe 
1               5                   10                  15      


Leu Val Phe Trp Phe Cys Leu Pro Val Gly Leu Leu Leu Leu Leu Ile 
            20                  25                  30          


Ile Trp Leu Arg Phe Leu Leu Ser Gln Asp Ser Glu Glu Asn Asp Ser 
        35                  40                  45              


Ser Val Cys Leu Asp Trp Glu Pro Trp Ser Lys Gly Pro Ala Glu Phe 
    50                  55                  60                  


Cys Trp Lys Gly Thr Leu His Gly Gln Glu Lys Glu Arg Pro Cys Trp 
65                  70                  75                  80  


<210>  547
<211>  179
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  547

Xaa Trp Phe Cys Leu Pro Val Gly Leu Leu Leu Leu Leu Ile Ile Trp 
1               5                   10                  15      


Leu Arg Phe Leu Leu Ser Gln Asp Ser Glu Glu Asn Asp Ser Ser Val 
            20                  25                  30          


Cys Leu Asp Trp Glu Pro Trp Ser Lys Gly Pro Ala Glu Phe Cys Trp 
        35                  40                  45              


Lys Gly Thr Leu His Gly Gln Glu Lys Glu Arg Pro Cys Cys Leu Val 
    50                  55                  60                  


Phe Leu Glu Ser Ala Gly Gln Trp Gln Trp Gln Lys Trp Met Gly Glu 
65                  70                  75                  80  


Thr Cys Gln Gly Gly Lys Arg Thr Leu Ala Thr Val Val Pro Pro Trp 
                85                  90                  95      


Asn Pro Gln Leu Ile Ser Ser Ser Asp Arg His Val Lys Ala Ser Arg 
            100                 105                 110         


Gly Pro Ser Pro Ser Pro Ala Ser Gln Met Thr Ser Ser Pro Ala Gly 
        115                 120                 125             


Ser Arg Ser Ser Leu Gly Gly His Gly Ser Ser Glu Gln Ala His Gly 
    130                 135                 140                 


Glu Lys Leu Ala Asn Leu Ile Gln Arg Gly Leu Lys Ala Gly Leu Gly 
145                 150                 155                 160 


Arg Arg Val Trp Val His Ile Lys Glu Ala Arg Val Phe Pro Tyr Pro 
                165                 170                 175     


Gly Asp Pro 
            


<210>  548
<211>  244
<212>  PRT
<213>  Homo Sapiens

<400>  548

Met Leu Leu Leu Gly Ala Val Leu Leu Leu Leu Ala Leu Pro Gly His 
1               5                   10                  15      


Asp Gln Glu Thr Thr Thr Gln Gly Pro Gly Val Leu Leu Pro Leu Pro 
            20                  25                  30          


Lys Gly Ala Cys Thr Gly Trp Met Ala Gly Ile Pro Gly His Pro Gly 
        35                  40                  45              


His Asn Gly Ala Pro Gly Arg Asp Gly Arg Asp Gly Thr Pro Gly Glu 
    50                  55                  60                  


Lys Gly Glu Lys Gly Asp Pro Gly Leu Ile Gly Pro Lys Gly Asp Ile 
65                  70                  75                  80  


Gly Glu Thr Gly Val Pro Gly Ala Glu Gly Pro Arg Gly Phe Pro Gly 
                85                  90                  95      


Ile Gln Gly Arg Lys Gly Glu Pro Gly Glu Gly Ala Tyr Val Tyr Arg 
            100                 105                 110         


Ser Ala Phe Ser Val Gly Leu Glu Thr Tyr Val Thr Ile Pro Asn Met 
        115                 120                 125             


Pro Ile Arg Phe Thr Lys Ile Phe Tyr Asn Gln Gln Asn His Tyr Asp 
    130                 135                 140                 


Gly Ser Thr Gly Lys Phe His Cys Asn Ile Pro Gly Leu Tyr Tyr Phe 
145                 150                 155                 160 


Ala Tyr His Ile Thr Val Tyr Met Lys Asp Val Lys Val Ser Leu Phe 
                165                 170                 175     


Lys Lys Asp Lys Ala Met Leu Phe Thr Tyr Asp Gln Tyr Gln Glu Asn 
            180                 185                 190         


Asn Val Asp Gln Ala Ser Gly Ser Val Leu Leu His Leu Glu Val Gly 
        195                 200                 205             


Asp Gln Val Trp Leu Gln Val Tyr Gly Glu Gly Glu Arg Asn Gly Leu 
    210                 215                 220                 


Tyr Ala Asp Asn Asp Asn Asp Ser Thr Phe Thr Gly Phe Leu Leu Tyr 
225                 230                 235                 240 


His Asp Thr Asn 
                


<210>  549
<211>  244
<212>  PRT
<213>  Homo Sapiens

<400>  549

Met Leu Leu Leu Gly Ala Val Leu Leu Leu Leu Ala Leu Pro Gly His 
1               5                   10                  15      


Asp Gln Glu Thr Thr Thr Gln Gly Pro Gly Val Leu Leu Pro Leu Pro 
            20                  25                  30          


Lys Gly Ala Cys Thr Gly Trp Met Ala Gly Ile Pro Gly His Pro Gly 
        35                  40                  45              


His Asn Gly Ala Pro Gly Arg Asp Gly Arg Asp Gly Thr Pro Gly Glu 
    50                  55                  60                  


Lys Gly Glu Lys Gly Asp Pro Gly Leu Ile Gly Pro Lys Gly Asp Ile 
65                  70                  75                  80  


Gly Glu Thr Gly Val Pro Gly Ala Glu Gly Pro Arg Gly Phe Pro Gly 
                85                  90                  95      


Ile Gln Gly Arg Lys Gly Glu Pro Gly Glu Gly Ala Tyr Val Tyr Arg 
            100                 105                 110         


Ser Ala Phe Ser Val Gly Leu Glu Thr Tyr Val Thr Ile Pro Asn Met 
        115                 120                 125             


Pro Ile Arg Phe Thr Lys Ile Phe Tyr Asn Gln Gln Asn His Tyr Asp 
    130                 135                 140                 


Gly Ser Thr Gly Lys Phe His Cys Asn Ile Pro Gly Leu Tyr Tyr Phe 
145                 150                 155                 160 


Ala Tyr His Ile Thr Val Tyr Met Lys Asp Val Lys Val Ser Leu Phe 
                165                 170                 175     


Lys Lys Asp Lys Ala Met Leu Phe Thr Tyr Asp Gln Tyr Gln Glu Asn 
            180                 185                 190         


Asn Val Asp Gln Ala Ser Gly Ser Val Leu Leu His Leu Glu Val Gly 
        195                 200                 205             


Asp Gln Val Trp Leu Gln Val Tyr Gly Glu Gly Glu Arg Asn Gly Leu 
    210                 215                 220                 


Tyr Ala Asp Asn Asp Asn Asp Ser Thr Phe Thr Gly Phe Leu Leu Tyr 
225                 230                 235                 240 


His Asp Thr Asn 
                


<210>  550
<211>  117
<212>  PRT
<213>  Homo Sapiens

<400>  550

Met Gly Ser Gln Val Ala Phe Leu Pro Pro Pro Pro Ala Arg Ser Ser 
1               5                   10                  15      


Pro Asp Ala Ala Arg Ile Arg Val Lys Arg Tyr Arg Gln Ser Met Asn 
            20                  25                  30          


Asn Phe Gln Gly Leu Arg Ser Phe Gly Cys Arg Phe Gly Thr Cys Thr 
        35                  40                  45              


Val Gln Lys Leu Ala His Gln Ile Tyr Gln Phe Thr Asp Lys Asp Lys 
    50                  55                  60                  


Asp Asn Val Ala Pro Arg Ser Lys Ile Ser Pro Gln Gly Tyr Gly Arg 
65                  70                  75                  80  


Arg Arg Arg Arg Ser Leu Pro Glu Ala Gly Pro Gly Arg Thr Leu Val 
                85                  90                  95      


Ser Ser Lys Pro Gln Ala His Gly Ala Pro Ala Pro Pro Ser Gly Ser 
            100                 105                 110         


Ala Pro His Phe Leu 
        115         


<210>  551
<211>  83
<212>  PRT
<213>  Homo Sapiens

<400>  551

Met Lys Leu Val Ser Val Ala Leu Met Tyr Leu Gly Ser Leu Ala Phe 
1               5                   10                  15      


Leu Gly Ala Asp Thr Ala Arg Leu Asp Val Ala Ser Glu Phe Arg Lys 
            20                  25                  30          


Lys Trp Asn Lys Trp Ala Leu Ser Arg Gly Lys Arg Glu Leu Arg Met 
        35                  40                  45              


Ser Ser Ser Tyr Pro Thr Gly Leu Ala Asp Val Lys Ala Gly Pro Ala 
    50                  55                  60                  


Gln Thr Leu Ile Arg Pro Gln Asp Met Lys Gly Ala Ser Arg Ser Pro 
65                  70                  75                  80  


Glu Asp Arg 
            


<210>  552
<211>  83
<212>  PRT
<213>  Homo Sapiens

<400>  552

Met Lys Leu Val Ser Val Ala Leu Met Tyr Leu Gly Ser Leu Ala Phe 
1               5                   10                  15      


Leu Gly Ala Asp Thr Ala Arg Leu Asp Val Ala Ser Glu Phe Arg Lys 
            20                  25                  30          


Lys Trp Asn Lys Trp Ala Leu Ser Arg Gly Lys Arg Glu Leu Arg Met 
        35                  40                  45              


Ser Ser Ser Tyr Pro Thr Gly Leu Ala Asp Val Lys Ala Gly Pro Ala 
    50                  55                  60                  


Gln Thr Leu Ile Arg Pro Gln Asp Met Lys Gly Ala Ser Arg Ser Pro 
65                  70                  75                  80  


Glu Asp Arg 
            


<210>  553
<211>  139
<212>  PRT
<213>  Homo Sapiens

<400>  553

Met Lys Leu Val Ser Val Ala Leu Met Tyr Leu Gly Ser Leu Ala Phe 
1               5                   10                  15      


Leu Gly Ala Asp Thr Ala Arg Leu Asp Val Ala Ser Glu Phe Arg Lys 
            20                  25                  30          


Lys Trp Asn Lys Trp Ala Leu Ser Arg Gly Lys Arg Glu Leu Arg Met 
        35                  40                  45              


Ser Ser Ser Tyr Pro Thr Gly Leu Ala Asp Val Lys Ala Gly Pro Ala 
    50                  55                  60                  


Gln Thr Leu Ile Arg Pro Gln Asp Met Lys Gly Ala Ser Arg Ser Pro 
65                  70                  75                  80  


Glu Asp Ser Cys Leu Ser Ser Pro Ser Pro Arg Pro Gln Gln Ser Gly 
                85                  90                  95      


Cys Arg Pro His Pro Ser Gln Ala Leu Pro Pro Glu His Glu Gln Leu 
            100                 105                 110         


Pro Gly Pro Pro Glu Leu Trp Leu Pro Leu Arg Asp Val His Gly Ala 
        115                 120                 125             


Glu Ala Gly Thr Pro Asp Leu Pro Val His Arg 
    130                 135                 


<210>  554
<211>  185
<212>  PRT
<213>  Homo Sapiens

<400>  554

Met Lys Leu Val Ser Val Ala Leu Met Tyr Leu Gly Ser Leu Ala Phe 
1               5                   10                  15      


Leu Gly Ala Asp Thr Ala Arg Leu Asp Val Ala Ser Glu Phe Arg Lys 
            20                  25                  30          


Lys Trp Asn Lys Trp Ala Leu Ser Arg Gly Lys Arg Glu Leu Arg Met 
        35                  40                  45              


Ser Ser Ser Tyr Pro Thr Gly Leu Ala Asp Val Lys Ala Gly Pro Ala 
    50                  55                  60                  


Gln Thr Leu Ile Arg Pro Gln Asp Met Lys Gly Ala Ser Arg Ser Pro 
65                  70                  75                  80  


Glu Asp Ser Ser Pro Asp Ala Ala Arg Ile Arg Val Lys Arg Tyr Arg 
                85                  90                  95      


Gln Ser Met Asn Asn Phe Gln Gly Leu Arg Ser Phe Gly Cys Arg Phe 
            100                 105                 110         


Gly Thr Cys Thr Val Gln Lys Leu Ala His Gln Ile Tyr Gln Phe Thr 
        115                 120                 125             


Asp Lys Asp Lys Asp Asn Val Ala Pro Arg Ser Lys Ile Ser Pro Gln 
    130                 135                 140                 


Gly Tyr Gly Arg Arg Arg Arg Arg Ser Leu Pro Glu Ala Gly Pro Gly 
145                 150                 155                 160 


Arg Thr Leu Val Ser Ser Lys Pro Gln Ala His Gly Ala Pro Ala Pro 
                165                 170                 175     


Pro Ser Gly Ser Ala Pro His Phe Leu 
            180                 185 


<210>  555
<211>  185
<212>  PRT
<213>  Homo Sapiens

<400>  555

Met Lys Leu Val Ser Val Ala Leu Met Tyr Leu Gly Ser Leu Ala Phe 
1               5                   10                  15      


Leu Gly Ala Asp Thr Ala Arg Leu Asp Val Ala Ser Glu Phe Arg Lys 
            20                  25                  30          


Lys Trp Asn Lys Trp Ala Leu Ser Arg Gly Lys Arg Glu Leu Arg Met 
        35                  40                  45              


Ser Ser Ser Tyr Pro Thr Gly Leu Ala Asp Val Lys Ala Gly Pro Ala 
    50                  55                  60                  


Gln Thr Leu Ile Arg Pro Gln Asp Met Lys Gly Ala Ser Arg Ser Pro 
65                  70                  75                  80  


Glu Asp Ser Ser Pro Asp Ala Ala Arg Ile Arg Val Lys Arg Tyr Arg 
                85                  90                  95      


Gln Ser Met Asn Asn Phe Gln Gly Leu Arg Ser Phe Gly Cys Arg Phe 
            100                 105                 110         


Gly Thr Cys Thr Val Gln Lys Leu Ala His Gln Ile Tyr Gln Phe Thr 
        115                 120                 125             


Asp Lys Asp Lys Asp Asn Val Ala Pro Arg Ser Lys Ile Ser Pro Gln 
    130                 135                 140                 


Gly Tyr Gly Arg Arg Arg Arg Arg Ser Leu Pro Glu Ala Gly Pro Gly 
145                 150                 155                 160 


Arg Thr Leu Val Ser Ser Lys Pro Gln Ala His Gly Ala Pro Ala Pro 
                165                 170                 175     


Pro Ser Gly Ser Ala Pro His Phe Leu 
            180                 185 


<210>  556
<211>  185
<212>  PRT
<213>  Homo Sapiens

<400>  556

Met Lys Leu Val Ser Val Ala Leu Met Tyr Leu Gly Ser Leu Ala Phe 
1               5                   10                  15      


Leu Gly Ala Asp Thr Ala Arg Leu Asp Val Ala Ser Glu Phe Arg Lys 
            20                  25                  30          


Lys Trp Asn Lys Trp Ala Leu Ser Arg Gly Lys Arg Glu Leu Arg Met 
        35                  40                  45              


Ser Ser Ser Tyr Pro Thr Gly Leu Ala Asp Val Lys Ala Gly Pro Ala 
    50                  55                  60                  


Gln Thr Leu Ile Arg Pro Gln Asp Met Lys Gly Ala Ser Arg Ser Pro 
65                  70                  75                  80  


Glu Asp Ser Ser Pro Asp Ala Ala Arg Ile Arg Val Lys Arg Tyr Arg 
                85                  90                  95      


Gln Ser Met Asn Asn Phe Gln Gly Leu Arg Ser Phe Gly Cys Arg Phe 
            100                 105                 110         


Gly Thr Cys Thr Val Gln Lys Leu Ala His Gln Ile Tyr Gln Phe Thr 
        115                 120                 125             


Asp Lys Asp Lys Asp Asn Val Ala Pro Arg Ser Lys Ile Ser Pro Gln 
    130                 135                 140                 


Gly Tyr Gly Arg Arg Arg Arg Arg Ser Leu Pro Glu Ala Gly Pro Gly 
145                 150                 155                 160 


Arg Thr Leu Val Ser Ser Lys Pro Gln Ala His Gly Ala Pro Ala Pro 
                165                 170                 175     


Pro Ser Gly Ser Ala Pro His Phe Leu 
            180                 185 


<210>  557
<211>  138
<212>  PRT
<213>  Homo Sapiens

<400>  557

Met Ser Ser Ser Tyr Pro Thr Gly Leu Ala Asp Val Lys Ala Gly Pro 
1               5                   10                  15      


Ala Gln Thr Leu Ile Arg Pro Gln Asp Met Lys Gly Ala Ser Arg Ser 
            20                  25                  30          


Pro Glu Asp Ser Ser Pro Asp Ala Ala Arg Ile Arg Val Lys Arg Tyr 
        35                  40                  45              


Arg Gln Ser Met Asn Asn Phe Gln Gly Leu Arg Ser Phe Gly Cys Arg 
    50                  55                  60                  


Phe Gly Thr Cys Thr Val Gln Lys Leu Ala His Gln Ile Tyr Gln Phe 
65                  70                  75                  80  


Thr Asp Lys Asp Lys Asp Asn Val Ala Pro Arg Ser Lys Ile Ser Pro 
                85                  90                  95      


Gln Gly Tyr Gly Arg Arg Arg Arg Arg Ser Leu Pro Glu Ala Gly Pro 
            100                 105                 110         


Gly Arg Thr Leu Val Ser Ser Lys Pro Gln Ala His Gly Ala Pro Ala 
        115                 120                 125             


Pro Pro Ser Gly Ser Ala Pro His Phe Leu 
    130                 135             


<210>  558
<211>  148
<212>  PRT
<213>  Homo Sapiens

<400>  558

Met Ala Arg Ile Pro Thr Ala Ala Leu Gly Cys Ile Ser Leu Leu Cys 
1               5                   10                  15      


Leu Gln Leu Pro Gly Ser Leu Ser Arg Ser Leu Gly Gly Asp Pro Arg 
            20                  25                  30          


Pro Val Lys Pro Arg Glu Pro Pro Ala Arg Ser Pro Ser Ser Ser Leu 
        35                  40                  45              


Gln Pro Arg His Pro Ala Pro Arg Pro Val Val Trp Lys Leu His Arg 
    50                  55                  60                  


Ala Leu Gln Ala Gln Arg Gly Ala Gly Leu Ala Pro Val Met Gly Gln 
65                  70                  75                  80  


Pro Leu Arg Asp Gly Gly Arg Gln His Ser Gly Pro Arg Arg His Ser 
                85                  90                  95      


Gly Pro Arg Arg Thr Gln Ala Gln Leu Leu Arg Val Gly Cys Val Leu 
            100                 105                 110         


Gly Thr Cys Gln Val Gln Asn Leu Ser His Arg Leu Trp Gln Leu Met 
        115                 120                 125             


Gly Pro Ala Gly Arg Gln Asp Ser Ala Pro Val Asp Pro Ser Ser Pro 
    130                 135                 140                 


His Ser Tyr Gly 
145             


<210>  559
<211>  148
<212>  PRT
<213>  Homo Sapiens

<400>  559

Met Ala Arg Ile Pro Thr Ala Ala Leu Gly Cys Ile Ser Leu Leu Cys 
1               5                   10                  15      


Leu Gln Leu Pro Gly Ser Leu Ser Arg Ser Leu Gly Gly Asp Pro Arg 
            20                  25                  30          


Pro Val Lys Pro Arg Glu Pro Pro Ala Arg Ser Pro Ser Ser Ser Leu 
        35                  40                  45              


Gln Pro Arg His Pro Ala Pro Arg Pro Val Val Trp Lys Leu His Arg 
    50                  55                  60                  


Ala Leu Gln Ala Gln Arg Gly Ala Gly Leu Ala Pro Val Met Gly Gln 
65                  70                  75                  80  


Pro Leu Arg Asp Gly Gly Arg Gln His Ser Gly Pro Arg Arg His Ser 
                85                  90                  95      


Gly Pro Arg Arg Thr Gln Ala Gln Leu Leu Arg Val Gly Cys Val Leu 
            100                 105                 110         


Gly Thr Cys Gln Val Gln Asn Leu Ser His Arg Leu Trp Gln Leu Met 
        115                 120                 125             


Gly Pro Ala Gly Arg Gln Asp Ser Ala Pro Val Asp Pro Ser Ser Pro 
    130                 135                 140                 


His Ser Tyr Gly 
145             


<210>  560
<211>  153
<212>  PRT
<213>  Homo Sapiens

<400>  560

Met Thr Ile His Ile Leu Ile Leu Leu Leu Leu Leu Ala Phe Ser Ala 
1               5                   10                  15      


Gln Gly Asp Leu Asp Thr Ala Ala Arg Arg Gly Gln His Gln Val Pro 
            20                  25                  30          


Gln His Arg Gly His Val Cys Tyr Leu Gly Val Cys Arg Thr His Arg 
        35                  40                  45              


Leu Ala Glu Ile Ile Tyr Trp Ile Arg Cys Leu His Gln Gly Ala Leu 
    50                  55                  60                  


Gly Glu Gly Gln Pro Arg Ala Pro Gly Pro Leu Gln Leu Trp Ala Pro 
65                  70                  75                  80  


Pro Val Ala Arg Gly Gly Ser Pro Ala Arg Phe Pro Gly Phe Arg Pro 
                85                  90                  95      


Ala Ala Arg Gly Leu Ala Gln Cys Pro Ala Arg Trp Val Thr Ser Gly 
            100                 105                 110         


Thr Ala Arg Pro Leu Leu Gly Phe Ser Leu Pro Ile Cys Met Leu Glu 
        115                 120                 125             


Leu Leu Leu His Ile Ser Ser Pro Leu Thr Pro Ala Pro Glu Thr Val 
    130                 135                 140                 


Phe Pro Ser Pro Ser Pro Gly Cys Asp 
145                 150             


<210>  561
<211>  57
<212>  PRT
<213>  Homo Sapiens

<400>  561

Leu Leu Glu Pro Glu Leu Pro Gly Ser Ala Leu Arg Ser Leu Trp Ser 
1               5                   10                  15      


Ser Leu Cys Leu Gly Pro Ala Pro Ala Pro Pro Gly Pro Val Ser Pro 
            20                  25                  30          


Glu Gly Arg Leu Ala Ala Ala Trp Asp Ala Leu Ile Val Arg Pro Val 
        35                  40                  45              


Arg Arg Trp Arg Arg Val Ala Val Gly 
    50                  55          


<210>  562
<211>  222
<212>  PRT
<213>  Homo Sapiens

<400>  562

Met Ala Ala Ser Cys Arg Val Val Thr Ser Ile Ser Asp Ile Pro Thr 
1               5                   10                  15      


Gly Ile Pro Val His Leu Glu Leu Ala Ser Met Thr Asn Arg Glu Leu 
            20                  25                  30          


Met Ser Ser Ile Val His Gln Val Phe Pro Ala Val Thr Ser Leu Gly 
        35                  40                  45              


Leu Asn Glu Gln Glu Leu Leu Phe Leu Thr Gln Ser Ala Ser Gly Pro 
    50                  55                  60                  


His Ser Ser Leu Ser Ser Trp Asn Gly Val Pro Asp Val Gly Met Val 
65                  70                  75                  80  


Ser Asp Ile Leu Phe Trp Ile Leu Lys Glu His Gly Arg Ser Lys Ser 
                85                  90                  95      


Arg Ala Ser Asp Leu Thr Arg Ile His Phe His Thr Leu Val Tyr His 
            100                 105                 110         


Ile Leu Ala Thr Val Asp Gly His Trp Ala Asn Gln Leu Ala Ala Val 
        115                 120                 125             


Ala Ala Gly Ala Arg Val Ala Gly Thr Gln Ala Cys Ala Thr Glu Thr 
    130                 135                 140                 


Ile Asp Thr Ser Arg Val Ser Leu Arg Ala Pro Gln Glu Phe Met Thr 
145                 150                 155                 160 


Ser His Ser Glu Ala Gly Ser Arg Ile Val Leu Asn Pro Asn Lys Pro 
                165                 170                 175     


Val Val Glu Trp His Arg Glu Gly Ile Ser Phe His Phe Thr Pro Val 
            180                 185                 190         


Leu Val Cys Lys Asp Pro Ile Arg Thr Val Gly Leu Gly Asp Ala Ile 
        195                 200                 205             


Ser Ala Glu Gly Leu Phe Tyr Ser Glu Val His Pro His Tyr 
    210                 215                 220         


<210>  563
<211>  78
<212>  PRT
<213>  Homo Sapiens

<400>  563

Met Ala Leu Trp Arg Gly Ser Ala Tyr Ala Gly Phe Leu Ala Leu Ala 
1               5                   10                  15      


Val Gly Cys Val Phe Leu Leu Glu Pro Glu Leu Pro Gly Ser Ala Leu 
            20                  25                  30          


Arg Ser Leu Trp Ser Ser Leu Cys Leu Gly Pro Ala Pro Ala Pro Pro 
        35                  40                  45              


Gly Pro Val Ser Pro Glu Gly Arg Leu Ala Ala Ala Trp Asp Ala Leu 
    50                  55                  60                  


Ile Val Arg Pro Val Arg Arg Trp Arg Arg Val Ala Val Gly 
65                  70                  75              


<210>  564
<211>  78
<212>  PRT
<213>  Homo Sapiens

<400>  564

Met Ala Leu Trp Arg Gly Ser Ala Tyr Ala Gly Phe Leu Ala Leu Ala 
1               5                   10                  15      


Val Gly Cys Val Phe Leu Leu Glu Pro Glu Leu Pro Gly Ser Ala Leu 
            20                  25                  30          


Arg Ser Leu Trp Ser Ser Leu Cys Leu Gly Pro Ala Pro Ala Pro Pro 
        35                  40                  45              


Gly Pro Val Ser Pro Glu Gly Arg Leu Ala Ala Ala Trp Asp Ala Leu 
    50                  55                  60                  


Ile Val Arg Pro Val Arg Arg Trp Arg Arg Val Ala Val Gly 
65                  70                  75              


<210>  565
<211>  78
<212>  PRT
<213>  Homo Sapiens

<400>  565

Met Ala Leu Trp Arg Gly Ser Ala Tyr Ala Gly Phe Leu Ala Leu Ala 
1               5                   10                  15      


Val Gly Cys Val Phe Leu Leu Glu Pro Glu Leu Pro Gly Ser Ala Leu 
            20                  25                  30          


Arg Ser Leu Trp Ser Ser Leu Cys Leu Gly Pro Ala Pro Ala Pro Pro 
        35                  40                  45              


Gly Pro Val Ser Pro Glu Gly Arg Leu Ala Ala Ala Trp Asp Ala Leu 
    50                  55                  60                  


Ile Val Arg Pro Val Arg Arg Trp Arg Arg Val Ala Val Gly 
65                  70                  75              


<210>  566
<211>  113
<212>  PRT
<213>  Homo Sapiens

<400>  566

Met Ala Leu Trp Arg Gly Ser Ala Tyr Ala Gly Phe Leu Ala Leu Ala 
1               5                   10                  15      


Val Gly Cys Val Phe Leu Leu Glu Pro Glu Leu Pro Gly Ser Ala Leu 
            20                  25                  30          


Arg Ser Leu Trp Ser Ser Leu Cys Leu Gly Pro Ala Pro Ala Pro Pro 
        35                  40                  45              


Gly Pro Val Ser Pro Glu Gly Arg Leu Ala Ala Ala Trp Asp Ala Leu 
    50                  55                  60                  


Ile Val Arg Pro Val Arg Arg Trp Arg Arg Val Ala Val Gly Phe Phe 
65                  70                  75                  80  


Phe Ala Val Gln Leu Val Gln Ser Tyr Met Ser Phe Leu Met Thr Met 
                85                  90                  95      


Ser Leu Phe His Gln Ser His Cys Arg Lys Trp Met Ser Ser Thr Ser 
            100                 105                 110         


Phe 
    


<210>  567
<211>  496
<212>  PRT
<213>  Homo Sapiens

<400>  567

Met Ala Leu Trp Arg Gly Ser Ala Tyr Ala Gly Phe Leu Ala Leu Ala 
1               5                   10                  15      


Val Gly Cys Val Phe Leu Leu Glu Pro Glu Leu Pro Gly Ser Ala Leu 
            20                  25                  30          


Arg Ser Leu Trp Ser Ser Leu Cys Leu Gly Pro Ala Pro Ala Pro Pro 
        35                  40                  45              


Gly Pro Val Ser Pro Glu Gly Arg Leu Ala Ala Ala Trp Asp Ala Leu 
    50                  55                  60                  


Ile Val Arg Pro Val Arg Arg Trp Arg Arg Val Ala Val Gly Val Asn 
65                  70                  75                  80  


Ala Cys Val Asp Val Val Leu Ser Gly Val Lys Leu Leu Gln Ala Leu 
                85                  90                  95      


Gly Leu Ser Pro Gly Asn Gly Lys Asp His Ser Ile Leu His Ser Arg 
            100                 105                 110         


Asn Asp Leu Glu Glu Ala Phe Ile His Phe Met Gly Lys Gly Ala Ala 
        115                 120                 125             


Ala Glu Arg Phe Phe Ser Asp Lys Glu Thr Phe His Asp Ile Ala Gln 
    130                 135                 140                 


Val Ala Ser Glu Phe Pro Gly Ala Gln His Tyr Val Gly Gly Asn Ala 
145                 150                 155                 160 


Ala Leu Ile Gly Gln Lys Phe Ala Ala Asn Ser Asp Leu Lys Val Leu 
                165                 170                 175     


Leu Cys Gly Pro Val Gly Pro Lys Leu His Glu Leu Leu Asp Asp Asn 
            180                 185                 190         


Val Phe Val Pro Pro Glu Ser Leu Gln Glu Val Asp Glu Phe His Leu 
        195                 200                 205             


Ile Leu Glu Tyr Gln Ala Gly Glu Glu Trp Gly Gln Leu Lys Ala Pro 
    210                 215                 220                 


His Ala Asn Arg Phe Ile Phe Ser His Asp Leu Ser Asn Gly Ala Met 
225                 230                 235                 240 


Asn Met Leu Glu Val Phe Val Ser Ser Leu Glu Glu Phe Gln Pro Asp 
                245                 250                 255     


Leu Val Val Leu Ser Gly Leu His Met Met Glu Gly Gln Ser Lys Glu 
            260                 265                 270         


Leu Gln Arg Lys Arg Leu Leu Glu Val Val Thr Ser Ile Ser Asp Ile 
        275                 280                 285             


Pro Thr Gly Ile Pro Val His Leu Glu Leu Ala Ser Met Thr Asn Arg 
    290                 295                 300                 


Glu Leu Met Ser Ser Ile Val His Gln Val Phe Pro Ala Val Thr Ser 
305                 310                 315                 320 


Leu Gly Leu Asn Glu Gln Glu Leu Leu Phe Leu Thr Gln Ser Ala Ser 
                325                 330                 335     


Gly Pro His Ser Ser Leu Ser Ser Trp Asn Gly Val Pro Asp Val Gly 
            340                 345                 350         


Met Val Ser Asp Ile Leu Phe Trp Ile Leu Lys Glu His Gly Arg Ser 
        355                 360                 365             


Lys Ser Arg Ala Ser Asp Leu Thr Arg Ile His Phe His Thr Leu Val 
    370                 375                 380                 


Tyr His Ile Leu Ala Thr Val Asp Gly His Trp Ala Asn Gln Leu Ala 
385                 390                 395                 400 


Ala Val Ala Ala Gly Ala Arg Val Ala Gly Thr Gln Ala Cys Ala Thr 
                405                 410                 415     


Glu Thr Ile Asp Thr Ser Arg Val Ser Leu Arg Ala Pro Gln Glu Phe 
            420                 425                 430         


Met Thr Ser His Ser Glu Ala Gly Ser Arg Ile Val Leu Asn Pro Asn 
        435                 440                 445             


Lys Pro Val Val Glu Trp His Arg Glu Gly Ile Ser Phe His Phe Thr 
    450                 455                 460                 


Pro Val Leu Val Cys Lys Asp Pro Ile Arg Thr Val Gly Leu Gly Asp 
465                 470                 475                 480 


Ala Ile Ser Ala Glu Gly Leu Phe Tyr Ser Glu Val His Pro His Tyr 
                485                 490                 495     


<210>  568
<211>  154
<212>  PRT
<213>  Homo Sapiens

<400>  568

Met Gly Lys Gly Ala Ala Ala Glu Arg Phe Phe Ser Asp Lys Glu Thr 
1               5                   10                  15      


Phe His Asp Ile Ala Gln Val Ala Ser Glu Phe Pro Gly Ala Gln His 
            20                  25                  30          


Tyr Val Gly Gly Asn Ala Ala Leu Ile Gly Gln Lys Phe Ala Ala Asn 
        35                  40                  45              


Ser Asp Leu Lys Val Leu Leu Cys Gly Pro Val Gly Pro Lys Leu His 
    50                  55                  60                  


Glu Leu Leu Asp Asp Asn Val Phe Val Pro Pro Glu Ser Leu Gln Glu 
65                  70                  75                  80  


Val Asp Glu Phe His Leu Ile Leu Glu Tyr Gln Ala Gly Glu Glu Trp 
                85                  90                  95      


Gly Gln Leu Lys Ala Pro His Ala Asn Arg Phe Ile Phe Ser His Asp 
            100                 105                 110         


Leu Ser Asn Gly Ala Met Asn Met Leu Glu Val Phe Val Ser Ser Leu 
        115                 120                 125             


Glu Glu Phe Gln Pro Asp Leu Val Val Leu Ser Gly Leu His Met Met 
    130                 135                 140                 


Glu Gly Gln Ser Lys Glu Leu Gln Arg Lys 
145                 150                 


<210>  569
<211>  204
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  569

Xaa Glu Pro Glu Leu Pro Gly Ser Ala Leu Arg Ser Leu Trp Ser Ser 
1               5                   10                  15      


Leu Cys Leu Gly Pro Ala Pro Ala Pro Pro Gly Pro Val Ser Pro Glu 
            20                  25                  30          


Gly Arg Leu Ala Ala Ala Trp Asp Ala Leu Ile Val Arg Pro Val Arg 
        35                  40                  45              


Arg Trp Arg Arg Val Ala Val Gly Val Asn Ala Cys Val Asp Val Val 
    50                  55                  60                  


Leu Ser Gly Val Lys Leu Leu Gln Ala Leu Gly Leu Ser Pro Gly Asn 
65                  70                  75                  80  


Gly Lys Asp His Ser Ile Leu His Ser Arg Asn Asp Leu Glu Glu Ala 
                85                  90                  95      


Phe Ile His Phe Met Gly Lys Gly Ala Ala Ala Glu Arg Phe Phe Ser 
            100                 105                 110         


Asp Lys Glu Thr Phe His Asp Ile Ala Gln Val Ala Ser Glu Phe Pro 
        115                 120                 125             


Gly Ala Gln His Tyr Val Gly Gly Asn Ala Ala Leu Ile Gly Gln Lys 
    130                 135                 140                 


Phe Ala Ala Asn Ser Asp Leu Lys Val Leu Leu Cys Gly Pro Val Gly 
145                 150                 155                 160 


Pro Lys Leu His Glu Leu Leu Asp Asp Asn Val Phe Val Pro Pro Glu 
                165                 170                 175     


Ser Leu Gln Glu Val Asp Glu Phe His Leu Ile Leu Glu Tyr Gln Ala 
            180                 185                 190         


Ala Gly Leu Ser Arg Gly Asp Phe Pro Trp Ala Glu 
        195                 200                 


<210>  570
<211>  26
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  570

Xaa Lys Arg Leu Leu Glu Val Leu Ala Ser Gln Gly His Ile Leu Ala 
1               5                   10                  15      


Ala Gly Cys Gly Ala Cys Leu Leu Leu Gln 
            20                  25      


<210>  571
<211>  363
<212>  PRT
<213>  Homo Sapiens

<400>  571

Met Ala Ala Ala Ala Met Ala Ala Ala Ala Gly Gly Gly Ala Gly Ala 
1               5                   10                  15      


Ala Arg Ser Leu Ser Arg Phe Arg Gly Cys Leu Ala Gly Ala Leu Leu 
            20                  25                  30          


Gly Asp Cys Val Gly Ser Phe Tyr Glu Ala His Asp Thr Val Asp Leu 
        35                  40                  45              


Thr Ser Val Leu Arg His Val Gln Ser Leu Glu Pro Asp Pro Gly Thr 
    50                  55                  60                  


Pro Gly Ser Glu Arg Thr Glu Ala Leu Tyr Tyr Thr Asp Asp Thr Ala 
65                  70                  75                  80  


Met Ala Arg Ala Leu Val Gln Ser Leu Leu Ala Lys Glu Ala Phe Asp 
                85                  90                  95      


Glu Val Asp Met Ala His Arg Phe Ala Gln Glu Tyr Lys Lys Asp Pro 
            100                 105                 110         


Asp Arg Gly Tyr Gly Ala Gly Val Val Thr Val Phe Lys Lys Leu Leu 
        115                 120                 125             


Asn Pro Lys Cys Arg Asp Val Phe Glu Pro Ala Arg Ala Gln Phe Asn 
    130                 135                 140                 


Gly Lys Gly Ser Tyr Gly Asn Gly Gly Ala Met Arg Val Ala Gly Ile 
145                 150                 155                 160 


Ser Leu Ala Tyr Ser Ser Val Gln Asp Val Gln Lys Phe Ala Arg Leu 
                165                 170                 175     


Ser Ala Gln Leu Thr His Ala Ser Ser Leu Gly Tyr Asn Gly Ala Ile 
            180                 185                 190         


Leu Gln Ala Leu Ala Val His Leu Ala Leu Gln Gly Glu Ser Ser Ser 
        195                 200                 205             


Glu His Phe Leu Lys Gln Leu Leu Gly His Met Glu Asp Leu Glu Gly 
    210                 215                 220                 


Asp Ala Gln Ser Val Leu Asp Ala Arg Glu Leu Gly Met Glu Glu Arg 
225                 230                 235                 240 


Pro Tyr Ser Ser Arg Leu Lys Lys Ile Gly Glu Leu Leu Asp Gln Ala 
                245                 250                 255     


Ser Val Thr Arg Glu Glu Val Val Ser Glu Leu Gly Asn Gly Ile Ala 
            260                 265                 270         


Ala Phe Glu Ser Val Pro Thr Ala Ile Tyr Cys Phe Leu Arg Cys Met 
        275                 280                 285             


Glu Pro Asp Pro Glu Ile Pro Ser Ala Phe Asn Ser Leu Gln Arg Thr 
    290                 295                 300                 


Leu Ile Tyr Ser Ile Ser Leu Gly Gly Asp Thr Asp Thr Ile Ala Thr 
305                 310                 315                 320 


Met Ala Gly Ala Ile Ala Gly Ala Tyr Tyr Gly Met Asp Gln Val Pro 
                325                 330                 335     


Glu Ser Trp Gln Gln Ser Cys Glu Gly Tyr Glu Glu Thr Asp Ile Leu 
            340                 345                 350         


Ala Gln Ser Leu His Arg Val Phe Gln Lys Ser 
        355                 360             


<210>  572
<211>  69
<212>  PRT
<213>  Homo Sapiens

<400>  572

Lys Pro Asp Ala Glu Arg Gln Thr Asp Glu Glu Lys Glu Glu Leu Lys 
1               5                   10                  15      


Lys Pro Lys Lys Glu Asp Ser Ser Pro Lys Glu Glu Thr Asp Lys Trp 
            20                  25                  30          


Ala Val Glu Lys Gly Lys Asp His Lys Glu Pro Arg Lys Gly Glu Glu 
        35                  40                  45              


Leu Glu Glu Glu Trp Thr Pro Thr Glu Lys Val Arg Pro Leu Cys Arg 
    50                  55                  60                  


Arg Ser Pro Ser Gly 
65                  


<210>  573
<211>  54
<212>  PRT
<213>  Homo Sapiens

<400>  573

Leu Met Lys Val Val Asn Glu Glu Cys Pro Thr Ile Thr Arg Thr Tyr 
1               5                   10                  15      


Ser Leu Gly Lys Ser Ser Arg Gly Leu Lys Ile Tyr Ala Met Glu Ile 
            20                  25                  30          


Ser Asp Asn Pro Gly Glu His Glu Leu Gly Glu Gly Leu Trp Gly Pro 
        35                  40                  45              


Ala Ala Gly Leu Cys Cys 
    50                  


<210>  574
<211>  1158
<212>  PRT
<213>  Homo Sapiens

<400>  574

Met Ala Ala Val Arg Gly Ala Pro Leu Leu Ser Cys Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Leu Cys Pro Gly Gly Arg Pro Gln Thr Val Leu Thr Asp Asp 
            20                  25                  30          


Glu Ile Glu Glu Phe Leu Glu Gly Phe Leu Ser Glu Leu Glu Pro Glu 
        35                  40                  45              


Pro Arg Glu Asp Asp Val Glu Ala Pro Pro Pro Pro Glu Pro Thr Pro 
    50                  55                  60                  


Arg Val Arg Lys Ala Gln Ala Gly Gly Lys Pro Gly Lys Arg Pro Gly 
65                  70                  75                  80  


Thr Ala Ala Glu Val Pro Pro Glu Lys Thr Lys Asp Lys Gly Lys Lys 
                85                  90                  95      


Gly Lys Lys Asp Lys Gly Pro Lys Val Pro Lys Glu Ser Leu Glu Gly 
            100                 105                 110         


Ser Pro Arg Pro Pro Lys Lys Gly Lys Glu Lys Pro Pro Lys Ala Thr 
        115                 120                 125             


Lys Lys Pro Lys Glu Lys Pro Pro Lys Ala Thr Lys Lys Pro Lys Glu 
    130                 135                 140                 


Lys Pro Pro Lys Ala Thr Lys Lys Pro Lys Glu Lys Pro Pro Lys Ala 
145                 150                 155                 160 


Thr Lys Lys Pro Pro Ser Gly Lys Arg Pro Pro Ile Leu Ala Pro Ser 
                165                 170                 175     


Glu Thr Leu Glu Trp Pro Leu Pro Pro Pro Pro Ser Pro Gly Pro Glu 
            180                 185                 190         


Glu Leu Pro Gln Glu Gly Gly Ala Pro Leu Ser Asn Asn Trp Gln Asn 
        195                 200                 205             


Pro Gly Glu Glu Thr His Val Glu Ala Arg Glu His Gln Pro Glu Pro 
    210                 215                 220                 


Glu Glu Glu Thr Glu Gln Pro Thr Leu Asp Tyr Asn Asp Gln Ile Glu 
225                 230                 235                 240 


Arg Glu Asp Tyr Glu Asp Phe Glu Tyr Ile Arg Arg Gln Lys Gln Pro 
                245                 250                 255     


Arg Pro Pro Pro Ser Arg Arg Arg Arg Pro Glu Arg Val Trp Pro Glu 
            260                 265                 270         


Pro Pro Glu Glu Lys Ala Pro Ala Pro Ala Pro Glu Glu Arg Ile Glu 
        275                 280                 285             


Pro Pro Val Lys Pro Leu Leu Pro Pro Leu Pro Pro Asp Tyr Gly Asp 
    290                 295                 300                 


Gly Tyr Val Ile Pro Asn Tyr Asp Asp Met Asp Tyr Tyr Phe Gly Pro 
305                 310                 315                 320 


Pro Pro Pro Gln Lys Pro Asp Ala Glu Arg Gln Thr Asp Glu Glu Lys 
                325                 330                 335     


Glu Glu Leu Lys Lys Pro Lys Lys Glu Asp Ser Ser Pro Lys Glu Glu 
            340                 345                 350         


Thr Asp Lys Trp Ala Val Glu Lys Gly Lys Asp His Lys Glu Pro Arg 
        355                 360                 365             


Lys Gly Glu Glu Leu Glu Glu Glu Trp Thr Pro Thr Glu Lys Val Lys 
    370                 375                 380                 


Cys Pro Pro Ile Gly Met Glu Ser His Arg Ile Glu Asp Asn Gln Ile 
385                 390                 395                 400 


Arg Ala Ser Ser Met Leu Arg His Gly Leu Gly Ala Gln Arg Gly Arg 
                405                 410                 415     


Leu Asn Met Gln Thr Gly Ala Thr Glu Asp Asp Tyr Tyr Asp Gly Ala 
            420                 425                 430         


Trp Cys Ala Glu Asp Asp Ala Arg Thr Gln Trp Ile Glu Val Asp Thr 
        435                 440                 445             


Arg Arg Thr Thr Arg Phe Thr Gly Val Ile Thr Gln Gly Arg Asp Ser 
    450                 455                 460                 


Ser Ile His Asp Asp Phe Val Thr Thr Phe Phe Val Gly Phe Ser Asn 
465                 470                 475                 480 


Asp Ser Gln Thr Trp Val Met Tyr Thr Asn Gly Tyr Glu Glu Met Thr 
                485                 490                 495     


Phe His Gly Asn Val Asp Lys Asp Thr Pro Val Leu Ser Glu Leu Pro 
            500                 505                 510         


Glu Pro Val Val Ala Arg Phe Ile Arg Ile Tyr Pro Leu Thr Trp Asn 
        515                 520                 525             


Gly Ser Leu Cys Met Arg Leu Glu Val Leu Gly Cys Ser Val Ala Pro 
    530                 535                 540                 


Val Tyr Ser Tyr Tyr Ala Gln Asn Glu Val Val Ala Thr Asp Asp Leu 
545                 550                 555                 560 


Asp Phe Arg His His Ser Tyr Lys Asp Met Arg Gln Leu Met Lys Val 
                565                 570                 575     


Val Asn Glu Glu Cys Pro Thr Ile Thr Arg Thr Tyr Ser Leu Gly Lys 
            580                 585                 590         


Ser Ser Arg Gly Leu Lys Ile Tyr Ala Met Glu Ile Ser Asp Asn Pro 
        595                 600                 605             


Gly Glu His Glu Leu Gly Glu Pro Glu Phe Arg Tyr Thr Ala Gly Ile 
    610                 615                 620                 


His Gly Asn Glu Val Leu Gly Arg Glu Leu Leu Leu Leu Leu Met Gln 
625                 630                 635                 640 


Tyr Leu Cys Arg Glu Tyr Arg Asp Gly Asn Pro Arg Val Arg Ser Leu 
                645                 650                 655     


Val Gln Asp Thr Arg Ile His Leu Val Pro Ser Leu Asn Pro Asp Gly 
            660                 665                 670         


Tyr Glu Val Ala Ala Gln Met Gly Ser Glu Phe Gly Asn Trp Ala Leu 
        675                 680                 685             


Gly Leu Trp Thr Glu Glu Gly Phe Asp Ile Phe Glu Asp Phe Pro Asp 
    690                 695                 700                 


Leu Asn Ser Val Leu Trp Gly Ala Glu Glu Arg Lys Trp Val Pro Tyr 
705                 710                 715                 720 


Arg Val Pro Asn Asn Asn Leu Pro Ile Pro Glu Arg Tyr Leu Ser Pro 
                725                 730                 735     


Asp Ala Thr Val Ser Thr Glu Val Arg Ala Ile Ile Ala Trp Met Glu 
            740                 745                 750         


Lys Asn Pro Phe Val Leu Gly Ala Asn Leu Asn Gly Gly Glu Arg Leu 
        755                 760                 765             


Val Ser Tyr Pro Tyr Asp Met Ala Arg Thr Pro Thr Gln Glu Gln Leu 
    770                 775                 780                 


Leu Ala Ala Ala Met Ala Ala Ala Arg Gly Glu Asp Glu Asp Glu Val 
785                 790                 795                 800 


Ser Glu Ala Gln Glu Thr Pro Asp His Ala Ile Phe Arg Trp Leu Ala 
                805                 810                 815     


Ile Ser Phe Ala Ser Ala His Leu Thr Leu Thr Glu Pro Tyr Arg Gly 
            820                 825                 830         


Gly Cys Gln Ala Gln Asp Tyr Thr Gly Gly Met Gly Ile Val Asn Gly 
        835                 840                 845             


Ala Lys Trp Asn Pro Arg Thr Gly Thr Ile Asn Asp Phe Ser Tyr Leu 
    850                 855                 860                 


His Thr Asn Cys Leu Glu Leu Ser Phe Tyr Leu Gly Cys Asp Lys Phe 
865                 870                 875                 880 


Pro His Glu Ser Glu Leu Pro Arg Glu Trp Glu Asn Asn Lys Glu Ala 
                885                 890                 895     


Leu Leu Thr Phe Met Glu Gln Val His Arg Gly Ile Lys Gly Val Val 
            900                 905                 910         


Thr Asp Glu Gln Gly Ile Pro Ile Ala Asn Ala Thr Ile Ser Val Ser 
        915                 920                 925             


Gly Ile Asn His Gly Val Lys Thr Ala Ser Gly Gly Asp Tyr Trp Arg 
    930                 935                 940                 


Ile Leu Asn Pro Gly Glu Tyr Arg Val Thr Ala His Ala Glu Gly Tyr 
945                 950                 955                 960 


Thr Pro Ser Ala Lys Thr Cys Asn Val Asp Tyr Asp Ile Gly Ala Thr 
                965                 970                 975     


Gln Cys Asn Phe Ile Leu Ala Arg Ser Asn Trp Lys Arg Ile Arg Glu 
            980                 985                 990         


Ile Met Ala Met Asn Gly Asn Arg  Pro Ile Pro His Ile  Asp Pro Ser 
        995                 1000                 1005             


Arg Pro  Met Thr Pro Gln Gln  Arg Arg Leu Gln Gln  Arg Arg Leu 
    1010                 1015                 1020             


Gln His  Arg Leu Arg Leu Arg  Ala Gln Met Arg Leu  Arg Arg Leu 
    1025                 1030                 1035             


Asn Ala  Thr Thr Thr Leu Gly  Pro His Thr Val Pro  Pro Thr Leu 
    1040                 1045                 1050             


Pro Pro  Ala Pro Ala Thr Thr  Leu Ser Thr Thr Ile  Glu Pro Trp 
    1055                 1060                 1065             


Gly Leu  Ile Pro Pro Thr Thr  Ala Gly Trp Glu Glu  Ser Glu Thr 
    1070                 1075                 1080             


Glu Thr  Tyr Thr Glu Val Val  Thr Glu Phe Gly Thr  Glu Val Glu 
    1085                 1090                 1095             


Pro Glu  Phe Gly Thr Lys Val  Glu Pro Glu Phe Glu  Thr Gln Leu 
    1100                 1105                 1110             


Glu Pro  Glu Phe Glu Thr Gln  Leu Glu Pro Glu Phe  Glu Glu Glu 
    1115                 1120                 1125             


Glu Glu  Glu Glu Lys Glu Glu  Glu Ile Ala Thr Gly  Gln Ala Phe 
    1130                 1135                 1140             


Pro Phe  Thr Thr Val Glu Thr  Tyr Thr Val Asn Phe  Gly Asp Phe 
    1145                 1150                 1155             


<210>  575
<211>  162
<212>  PRT
<213>  Homo Sapiens

<400>  575

Met Pro Pro Glu Lys Thr Lys Asp Lys Gly Lys Lys Gly Lys Lys Asp 
1               5                   10                  15      


Lys Gly Pro Lys Val Pro Lys Glu Ser Leu Glu Gly Ser Pro Arg Pro 
            20                  25                  30          


Pro Lys Lys Gly Lys Glu Lys Pro Pro Lys Ala Thr Lys Lys Pro Lys 
        35                  40                  45              


Glu Lys Pro Pro Lys Ala Thr Lys Lys Pro Lys Glu Lys Pro Pro Lys 
    50                  55                  60                  


Ala Thr Lys Lys Pro Lys Glu Lys Pro Pro Lys Ala Thr Lys Lys Pro 
65                  70                  75                  80  


Pro Ser Gly Lys Arg Pro Pro Ile Leu Ala Pro Ser Glu Thr Leu Glu 
                85                  90                  95      


Trp Pro Leu Pro Pro Pro Pro Ser Pro Gly Pro Glu Glu Leu Pro Gln 
            100                 105                 110         


Glu Gly Gly Ala Pro Leu Ser Asn Asn Trp Gln Asn Pro Gly Glu Glu 
        115                 120                 125             


Thr His Val Glu Ala Arg Glu His Gln Pro Glu Pro Glu Glu Glu Thr 
    130                 135                 140                 


Glu Gln Pro Thr Leu Asp Tyr Asn Asp Gln Ile Glu Arg Glu Asp Tyr 
145                 150                 155                 160 


Glu Asp 
        


<210>  576
<211>  733
<212>  PRT
<213>  Homo Sapiens

<400>  576

Met Arg Lys Trp Trp Ala Pro Cys Pro Gly Ser Trp Leu Cys Ser His 
1               5                   10                  15      


Cys Leu Gly Glu Gly Trp Ala Leu Arg Gly Ala Gly Ser Thr Ala Leu 
            20                  25                  30          


Arg Pro Ala Ser Pro Gln Thr Phe His Gly Asn Val Asp Lys Asp Thr 
        35                  40                  45              


Pro Val Leu Ser Glu Leu Pro Glu Pro Val Val Ala Arg Phe Ile Arg 
    50                  55                  60                  


Ile Tyr Pro Leu Thr Trp Asn Gly Ser Leu Cys Met Arg Leu Glu Val 
65                  70                  75                  80  


Leu Gly Cys Ser Val Ala Arg Glu Cys Gly Gly Leu Ala Gly Ala Leu 
                85                  90                  95      


Ser Gly Gly Gly Val Leu Gly Trp Ala Ser Arg His Pro Ala Lys Asp 
            100                 105                 110         


Asn Pro Ala Ser Leu Ala Ala Val Tyr Ser Tyr Tyr Ala Gln Asn Glu 
        115                 120                 125             


Val Val Ala Thr Asp Asp Leu Asp Phe Arg His His Ser Tyr Lys Asp 
    130                 135                 140                 


Met Arg Gln Leu Met Lys Val Val Asn Glu Glu Cys Pro Thr Ile Thr 
145                 150                 155                 160 


Arg Thr Tyr Ser Leu Gly Lys Ser Ser Arg Gly Leu Lys Ile Tyr Ala 
                165                 170                 175     


Met Glu Ile Ser Asp Asn Pro Gly Glu His Glu Leu Gly Glu Pro Glu 
            180                 185                 190         


Phe Arg Tyr Thr Ala Gly Ile His Gly Asn Glu Val Leu Gly Arg Glu 
        195                 200                 205             


Leu Leu Leu Leu Leu Met Gln Tyr Leu Cys Arg Glu Tyr Arg Asp Gly 
    210                 215                 220                 


Asn Pro Arg Val Arg Ser Leu Val Gln Asp Thr Arg Ile His Leu Val 
225                 230                 235                 240 


Pro Ser Leu Asn Pro Asp Gly Tyr Glu Val Ala Ala Gln Met Gly Ser 
                245                 250                 255     


Glu Phe Gly Asn Trp Ala Leu Gly Leu Trp Thr Glu Glu Gly Phe Asp 
            260                 265                 270         


Ile Phe Glu Asp Phe Pro Asp Leu Asn Ser Val Leu Trp Gly Ala Glu 
        275                 280                 285             


Glu Arg Lys Trp Val Pro Tyr Arg Val Pro Asn Asn Asn Leu Pro Ile 
    290                 295                 300                 


Pro Glu Arg Tyr Leu Ser Pro Asp Ala Thr Val Ser Thr Glu Val Arg 
305                 310                 315                 320 


Ala Ile Ile Ala Trp Met Glu Lys Asn Pro Phe Val Leu Gly Ala Asn 
                325                 330                 335     


Leu Asn Gly Gly Glu Arg Leu Val Ser Tyr Pro Tyr Asp Met Ala Arg 
            340                 345                 350         


Thr Pro Thr Gln Glu Gln Leu Leu Ala Ala Ala Met Ala Ala Ala Arg 
        355                 360                 365             


Gly Glu Asp Glu Asp Glu Val Ser Glu Ala Gln Glu Thr Pro Asp His 
    370                 375                 380                 


Ala Ile Phe Arg Trp Leu Ala Ile Ser Phe Ala Ser Ala His Leu Thr 
385                 390                 395                 400 


Leu Thr Glu Pro Tyr Arg Gly Gly Cys Gln Ala Gln Asp Tyr Thr Gly 
                405                 410                 415     


Gly Met Gly Ile Val Asn Gly Ala Lys Trp Asn Pro Arg Thr Gly Thr 
            420                 425                 430         


Ile Asn Asp Phe Ser Tyr Leu His Thr Asn Cys Leu Glu Leu Ser Phe 
        435                 440                 445             


Tyr Leu Gly Cys Asp Lys Phe Pro His Glu Ser Glu Leu Pro Arg Glu 
    450                 455                 460                 


Trp Glu Asn Asn Lys Glu Ala Leu Leu Thr Phe Met Glu Gln Val His 
465                 470                 475                 480 


Arg Gly Ile Lys Gly Val Val Thr Asp Glu Gln Gly Ile Pro Ile Ala 
                485                 490                 495     


Asn Ala Thr Ile Ser Val Ser Gly Ile Asn His Gly Val Lys Thr Ala 
            500                 505                 510         


Ser Gly Gly Asp Tyr Trp Arg Ile Leu Asn Pro Gly Glu Tyr Arg Val 
        515                 520                 525             


Thr Ala His Ala Glu Gly Tyr Thr Pro Ser Ala Lys Thr Cys Asn Val 
    530                 535                 540                 


Asp Tyr Asp Ile Gly Ala Thr Gln Cys Asn Phe Ile Leu Ala Arg Ser 
545                 550                 555                 560 


Asn Trp Lys Arg Ile Arg Glu Ile Met Ala Met Asn Gly Asn Arg Pro 
                565                 570                 575     


Ile Pro His Ile Asp Pro Ser Arg Pro Met Thr Pro Gln Gln Arg Arg 
            580                 585                 590         


Leu Gln Gln Arg Arg Leu Gln His Arg Leu Arg Leu Arg Ala Gln Met 
        595                 600                 605             


Arg Leu Arg Arg Leu Asn Ala Thr Thr Thr Leu Gly Pro His Thr Val 
    610                 615                 620                 


Pro Pro Thr Leu Pro Pro Ala Pro Ala Thr Thr Leu Ser Thr Thr Ile 
625                 630                 635                 640 


Glu Pro Trp Gly Leu Ile Pro Pro Thr Thr Ala Gly Trp Glu Glu Ser 
                645                 650                 655     


Glu Thr Glu Thr Tyr Thr Glu Val Val Thr Glu Phe Gly Thr Glu Val 
            660                 665                 670         


Glu Pro Glu Phe Gly Thr Lys Val Glu Pro Glu Phe Glu Thr Gln Leu 
        675                 680                 685             


Glu Pro Glu Phe Glu Thr Gln Leu Glu Pro Glu Phe Glu Glu Glu Glu 
    690                 695                 700                 


Glu Glu Glu Lys Glu Glu Glu Ile Ala Thr Gly Gln Ala Phe Pro Phe 
705                 710                 715                 720 


Thr Thr Val Glu Thr Tyr Thr Val Asn Phe Gly Asp Phe 
                725                 730             


<210>  577
<211>  104
<212>  PRT
<213>  Homo Sapiens

<400>  577

Arg Thr Gln Trp Ile Glu Val Asp Thr Arg Arg Thr Thr Arg Phe Thr 
1               5                   10                  15      


Gly Val Ile Thr Gln Gly Arg Asp Ser Ser Ile His Asp Asp Phe Val 
            20                  25                  30          


Thr Thr Phe Phe Val Gly Phe Ser Asn Asp Ser Gln Thr Trp Val Met 
        35                  40                  45              


Tyr Thr Asn Gly Tyr Glu Glu Met Val Gly Thr Met Pro Arg Leu Leu 
    50                  55                  60                  


Ala Leu Leu Pro Leu Ser Gly Arg Gly Val Gly Ser Gln Arg Gly Trp 
65                  70                  75                  80  


Gln Tyr Cys Ser Glu Ala Cys Leu Ser Pro Asp Leu Ser Trp Glu Arg 
                85                  90                  95      


Gly Gln Gly His Thr Arg Ala Glu 
            100                 


<210>  578
<211>  251
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  578

Xaa Glu Leu Glu Pro Glu Pro Arg Glu Asp Asp Val Glu Ala Pro Pro 
1               5                   10                  15      


Pro Pro Glu Pro Thr Pro Arg Val Arg Lys Ala Gln Ala Gly Gly Lys 
            20                  25                  30          


Pro Gly Lys Arg Pro Gly Thr Ala Ala Glu Val Pro Pro Glu Lys Thr 
        35                  40                  45              


Lys Asp Lys Gly Lys Lys Gly Lys Lys Asp Lys Gly Pro Lys Val Pro 
    50                  55                  60                  


Lys Glu Ser Leu Glu Gly Ser Pro Arg Pro Pro Lys Lys Gly Lys Glu 
65                  70                  75                  80  


Lys Pro Pro Lys Ala Thr Lys Lys Pro Lys Glu Lys Pro Pro Lys Ala 
                85                  90                  95      


Thr Lys Lys Pro Lys Glu Lys Pro Pro Lys Ala Thr Lys Lys Pro Lys 
            100                 105                 110         


Glu Lys Pro Pro Lys Ala Thr Lys Lys Pro Pro Ser Gly Lys Arg Pro 
        115                 120                 125             


Pro Ile Leu Ala Pro Ser Glu Thr Leu Glu Trp Pro Leu Pro Pro Pro 
    130                 135                 140                 


Pro Ser Pro Gly Pro Glu Glu Leu Pro Gln Glu Gly Gly Ala Pro Leu 
145                 150                 155                 160 


Ser Asn Asn Trp Gln Asn Pro Gly Glu Glu Thr His Val Glu Ala Arg 
                165                 170                 175     


Glu His Gln Pro Glu Pro Pro Val Lys Pro Leu Leu Pro Pro Leu Pro 
            180                 185                 190         


Pro Asp Tyr Gly Asp Gly Tyr Val Ile Pro Asn Tyr Asp Asp Met Asp 
        195                 200                 205             


Tyr Tyr Phe Gly Pro Pro Pro Pro Gln Lys Pro Asp Ala Glu Arg Gln 
    210                 215                 220                 


Thr Asp Glu Glu Lys Glu Glu Leu Lys Lys Pro Lys Lys Glu Asp Ser 
225                 230                 235                 240 


Ser Pro Lys Glu Glu Thr Asp Lys Trp Ala Val 
                245                 250     


<210>  579
<211>  66
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  579

Xaa Phe Arg His His Ser Tyr Lys Asp Met Arg Gln Leu Met Lys Val 
1               5                   10                  15      


Val Asn Glu Glu Cys Pro Thr Ile Thr Arg Thr Tyr Ser Leu Gly Lys 
            20                  25                  30          


Ser Ser Arg Gly Leu Lys Ile Tyr Ala Met Glu Ile Ser Asp Asn Pro 
        35                  40                  45              


Gly Glu His Glu Leu Gly Glu Gly Leu Trp Gly Pro Ala Ala Gly Leu 
    50                  55                  60                  


Cys Cys 
65      


<210>  580
<211>  481
<212>  PRT
<213>  Homo Sapiens

<400>  580

Met Ala Ala Ser Trp Ser Leu Leu Val Thr Leu Arg Pro Leu Ala Gln 
1               5                   10                  15      


Ser Pro Leu Arg Gly Arg Cys Val Gly Cys Gly Ala Trp Ala Ala Ala 
            20                  25                  30          


Leu Ala Pro Leu Ala Thr Ala Pro Gly Lys Pro Phe Trp Lys Ala Tyr 
        35                  40                  45              


Thr Val Gln Thr Ser Glu Ser Met Thr Pro Thr Ala Thr Ser Glu Thr 
    50                  55                  60                  


Tyr Leu Lys Ala Leu Ala Val Cys His Gly Pro Leu Asp His Tyr Asp 
65                  70                  75                  80  


Phe Leu Ile Lys Ala His Glu Leu Lys Asp Asp Glu His Gln Arg Arg 
                85                  90                  95      


Val Ile Gln Cys Leu Gln Lys Leu His Glu Asp Leu Lys Gly Tyr Asn 
            100                 105                 110         


Ile Glu Ala Glu Gly Leu Phe Ser Lys Leu Phe Ser Arg Ser Lys Pro 
        115                 120                 125             


Pro Arg Gly Leu Tyr Val Tyr Gly Asp Val Gly Thr Gly Lys Thr Met 
    130                 135                 140                 


Val Met Asp Met Phe Tyr Ala Tyr Val Glu Met Lys Arg Lys Lys Arg 
145                 150                 155                 160 


Val His Phe His Gly Phe Met Leu Asp Val His Lys Arg Ile His Arg 
                165                 170                 175     


Leu Lys Gln Ser Leu Pro Lys Arg Lys Pro Gly Phe Met Ala Lys Ser 
            180                 185                 190         


Tyr Asp Pro Ile Ala Pro Ile Ala Glu Glu Ile Ser Glu Glu Ala Cys 
        195                 200                 205             


Leu Leu Cys Phe Asp Glu Phe Gln Val Thr Asp Ile Ala Asp Ala Met 
    210                 215                 220                 


Ile Leu Lys Gln Leu Phe Glu Asn Leu Phe Lys Asn Gly Val Val Val 
225                 230                 235                 240 


Val Ala Thr Ser Asn Arg Pro Pro Glu Asp Leu Tyr Lys Asn Gly Leu 
                245                 250                 255     


Gln Arg Ala Asn Phe Val Pro Phe Ile Ala Val Leu Lys Glu Tyr Cys 
            260                 265                 270         


Asn Thr Val Gln Leu Asp Ser Gly Ile Asp Tyr Arg Lys Arg Glu Leu 
        275                 280                 285             


Pro Ala Ala Gly Lys Leu Tyr Tyr Leu Thr Ser Glu Ala Asp Val Glu 
    290                 295                 300                 


Ala Val Met Asp Lys Leu Phe Asp Glu Leu Ala Gln Lys Gln Asn Asp 
305                 310                 315                 320 


Leu Thr Arg Pro Arg Ile Leu Lys Val Gln Gly Arg Glu Leu Arg Leu 
                325                 330                 335     


Asn Lys Ala Cys Gly Thr Val Ala Asp Cys Thr Phe Glu Glu Leu Cys 
            340                 345                 350         


Glu Arg Pro Leu Gly Ala Ser Asp Tyr Leu Glu Leu Ser Lys Asn Phe 
        355                 360                 365             


Asp Thr Ile Phe Leu Arg Asn Ile Pro Gln Phe Thr Leu Ala Asn Arg 
    370                 375                 380                 


Thr Gln Gly Arg Arg Phe Ile Thr Leu Ile Asp Asn Phe Tyr Asp Leu 
385                 390                 395                 400 


Lys Val Arg Ile Ile Cys Ser Ala Ser Thr Pro Ile Ser Ser Leu Phe 
                405                 410                 415     


Leu His Gln His His Asp Ser Glu Leu Glu Gln Ser Arg Ile Leu Met 
            420                 425                 430         


Asp Asp Leu Gly Leu Ser Gln Asp Ser Ala Glu Gly Leu Ser Met Phe 
        435                 440                 445             


Thr Gly Glu Glu Glu Ile Phe Ala Phe Gln Arg Thr Ile Ser Arg Leu 
    450                 455                 460                 


Thr Glu Met Gln Thr Glu Gln Tyr Trp Asn Glu Gly Asp Arg Thr Lys 
465                 470                 475                 480 


Lys 
    


<210>  581
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  581

Met Cys Ala Thr Pro Pro Ser Leu Asn Phe Lys Lys Leu Ala Tyr Thr 
1               5                   10                  15      


Val Gln Thr Ser Glu Ser Met Thr Pro Thr Ala Thr Ser Glu Thr Tyr 
            20                  25                  30          


Leu Lys Ala Leu Ala Val Cys His Gly Pro Leu Asp His Tyr Asp Phe 
        35                  40                  45              


Leu Ile Lys Ala His Glu Leu Lys Asp Asp Glu His Gln Arg Arg Val 
    50                  55                  60                  


Ile Gln Cys Leu Gln Lys Leu His Glu Asp Leu Lys Gly Tyr Asn Ile 
65                  70                  75                  80  


Glu Ala Glu Gly Leu Phe Ser Lys Leu Phe Ser Arg Ser Lys Pro Pro 
                85                  90                  95      


Arg Gly Leu Tyr Val Tyr Gly Asp Val Gly Thr Gly Lys Thr Met Val 
            100                 105                 110         


Met Asp Met Phe Tyr Ala Tyr Val Glu Met Lys Arg Lys Lys Arg Val 
        115                 120                 125             


His Phe His Gly Phe Met Leu Asp Val His Lys Arg Ile His Arg Leu 
    130                 135                 140                 


Lys Gln Ser Leu Pro Lys Arg Lys Pro Gly Phe Met Ala Lys Ser Tyr 
145                 150                 155                 160 


<210>  582
<211>  80
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  582

Xaa Ile His Arg Leu Lys Gln Ser Leu Pro Lys Arg Lys Pro Gly Phe 
1               5                   10                  15      


Met Ala Lys Ser Tyr Asp Pro Ile Ala Pro Ile Ala Glu Glu Ile Ser 
            20                  25                  30          


Glu Glu Ala Cys Leu Leu Cys Phe Asp Glu Phe Gln Val Thr Asp Ile 
        35                  40                  45              


Ala Asp Ala Met Ile Leu Lys Gln Leu Phe Glu Asn Leu Phe Lys Asn 
    50                  55                  60                  


Gly Val Val Val Val Ala Thr Ser Asn Arg Pro Pro Glu Gly Ile Leu 
65                  70                  75                  80  


<210>  583
<211>  349
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  583

Xaa Lys Pro Phe Trp Lys Gly Thr Gly Lys Thr Met Val Met Asp Met 
1               5                   10                  15      


Phe Tyr Ala Tyr Val Glu Met Lys Arg Lys Lys Arg Val His Phe His 
            20                  25                  30          


Gly Phe Met Leu Asp Val His Lys Arg Ile His Arg Leu Lys Gln Ser 
        35                  40                  45              


Leu Pro Lys Arg Lys Pro Gly Phe Met Ala Lys Ser Tyr Asp Pro Ile 
    50                  55                  60                  


Ala Pro Ile Ala Glu Glu Ile Ser Glu Glu Ala Cys Leu Leu Cys Phe 
65                  70                  75                  80  


Asp Glu Phe Gln Val Thr Asp Ile Ala Asp Ala Met Ile Leu Lys Gln 
                85                  90                  95      


Leu Phe Glu Asn Leu Phe Lys Asn Gly Val Val Val Val Ala Thr Ser 
            100                 105                 110         


Asn Arg Pro Pro Glu Asp Leu Tyr Lys Asn Gly Leu Gln Arg Ala Asn 
        115                 120                 125             


Phe Val Pro Phe Ile Ala Val Leu Lys Glu Tyr Cys Asn Thr Val Gln 
    130                 135                 140                 


Leu Asp Ser Gly Ile Asp Tyr Arg Lys Arg Glu Leu Pro Ala Ala Gly 
145                 150                 155                 160 


Lys Leu Tyr Tyr Leu Thr Ser Glu Ala Asp Val Glu Ala Val Met Asp 
                165                 170                 175     


Lys Leu Phe Asp Glu Leu Ala Gln Lys Gln Asn Asp Leu Thr Arg Pro 
            180                 185                 190         


Arg Ile Leu Lys Val Gln Gly Arg Glu Leu Arg Leu Asn Lys Ala Cys 
        195                 200                 205             


Gly Thr Val Ala Asp Cys Thr Phe Glu Glu Leu Cys Glu Arg Pro Leu 
    210                 215                 220                 


Gly Ala Ser Asp Tyr Leu Glu Leu Ser Lys Asn Phe Asp Thr Ile Phe 
225                 230                 235                 240 


Leu Arg Asn Ile Pro Gln Phe Thr Leu Ala Asn Arg Thr Gln Gly Arg 
                245                 250                 255     


Arg Phe Ile Thr Leu Ile Asp Asn Phe Tyr Asp Leu Lys Val Arg Ile 
            260                 265                 270         


Ile Cys Ser Ala Ser Thr Pro Ile Ser Ser Leu Phe Leu His Gln His 
        275                 280                 285             


His Asp Ser Glu Leu Glu Gln Ser Arg Ile Leu Met Asp Asp Leu Gly 
    290                 295                 300                 


Leu Ser Gln Asp Ser Ala Glu Gly Leu Ser Met Phe Thr Gly Glu Glu 
305                 310                 315                 320 


Glu Ile Phe Ala Phe Gln Arg Thr Ile Ser Arg Leu Thr Glu Met Gln 
                325                 330                 335     


Thr Glu Gln Tyr Trp Asn Glu Gly Asp Arg Thr Lys Lys 
            340                 345                 


<210>  584
<211>  599
<212>  PRT
<213>  Homo Sapiens

<400>  584

Met Lys Leu Leu Lys Leu Thr Gly Phe Ile Phe Phe Leu Phe Phe Leu 
1               5                   10                  15      


Thr Glu Ser Leu Thr Leu Pro Thr Gln Pro Arg Asp Ile Glu Asn Phe 
            20                  25                  30          


Asn Ser Thr Gln Lys Phe Ile Glu Asp Asn Ile Glu Tyr Ile Thr Ile 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Val Gln Glu Ala Thr Phe Glu Glu Met Glu 
    50                  55                  60                  


Lys Leu Val Lys Asp Met Val Glu Tyr Lys Asp Arg Cys Met Ala Asp 
65                  70                  75                  80  


Lys Thr Leu Pro Glu Cys Ser Lys Leu Pro Asn Asn Val Leu Gln Glu 
                85                  90                  95      


Lys Ile Cys Ala Met Glu Gly Leu Pro Gln Lys His Asn Phe Ser His 
            100                 105                 110         


Cys Cys Ser Lys Val Asp Ala Gln Arg Arg Leu Cys Phe Phe Tyr Asn 
        115                 120                 125             


Lys Lys Ser Asp Val Gly Phe Leu Pro Pro Phe Pro Thr Leu Asp Pro 
    130                 135                 140                 


Glu Glu Lys Cys Gln Ala Tyr Glu Ser Asn Arg Glu Ser Leu Leu Asn 
145                 150                 155                 160 


His Phe Leu Tyr Glu Val Ala Arg Arg Asn Pro Phe Val Phe Ala Pro 
                165                 170                 175     


Thr Leu Leu Thr Val Ala Val His Phe Glu Glu Val Ala Lys Ser Cys 
            180                 185                 190         


Cys Glu Glu Gln Asn Lys Val Asn Cys Leu Gln Thr Arg Ala Ile Pro 
        195                 200                 205             


Val Thr Gln Tyr Leu Lys Ala Phe Ser Ser Tyr Gln Lys His Val Cys 
    210                 215                 220                 


Gly Ala Leu Leu Lys Phe Gly Thr Lys Val Val His Phe Ile Tyr Ile 
225                 230                 235                 240 


Ala Ile Leu Ser Gln Lys Phe Pro Lys Ile Glu Phe Lys Glu Leu Ile 
                245                 250                 255     


Ser Leu Val Glu Asp Val Ser Ser Asn Tyr Asp Gly Cys Cys Glu Gly 
            260                 265                 270         


Asp Val Val Gln Cys Ile Arg Asp Thr Ser Lys Val Met Asn His Ile 
        275                 280                 285             


Cys Ser Lys Gln Asp Ser Ile Ser Ser Lys Ile Lys Glu Cys Cys Glu 
    290                 295                 300                 


Lys Lys Ile Pro Glu Arg Gly Gln Cys Ile Ile Asn Ser Asn Lys Asp 
305                 310                 315                 320 


Asp Arg Pro Lys Asp Leu Ser Leu Arg Glu Gly Lys Phe Thr Asp Ser 
                325                 330                 335     


Glu Asn Val Cys Gln Glu Arg Asp Ala Asp Pro Asp Thr Phe Phe Ala 
            340                 345                 350         


Lys Phe Thr Phe Glu Tyr Ser Arg Arg His Pro Asp Leu Ser Ile Pro 
        355                 360                 365             


Glu Leu Leu Arg Ile Val Gln Ile Tyr Lys Asp Leu Leu Arg Asn Cys 
    370                 375                 380                 


Cys Asn Thr Glu Asn Pro Pro Gly Cys Tyr Arg Tyr Ala Glu Asp Lys 
385                 390                 395                 400 


Phe Asn Glu Thr Thr Glu Lys Ser Leu Lys Met Val Gln Gln Glu Cys 
                405                 410                 415     


Lys His Phe Gln Asn Leu Gly Lys Asp Gly Leu Lys Tyr His Tyr Leu 
            420                 425                 430         


Ile Arg Leu Thr Lys Ile Ala Pro Gln Leu Ser Thr Glu Glu Leu Val 
        435                 440                 445             


Ser Leu Gly Glu Lys Met Val Thr Ala Phe Thr Thr Cys Cys Thr Leu 
    450                 455                 460                 


Ser Glu Glu Phe Ala Cys Val Asp Asn Leu Ala Asp Leu Val Phe Gly 
465                 470                 475                 480 


Glu Leu Cys Gly Val Asn Glu Asn Arg Thr Ile Asn Pro Ala Val Asp 
                485                 490                 495     


His Cys Cys Lys Thr Asn Phe Ala Phe Arg Arg Pro Cys Phe Glu Ser 
            500                 505                 510         


Leu Lys Ala Asp Lys Thr Tyr Val Pro Pro Pro Phe Ser Gln Asp Leu 
        515                 520                 525             


Phe Thr Phe His Ala Asp Met Cys Gln Ser Gln Asn Glu Glu Leu Gln 
    530                 535                 540                 


Arg Lys Thr Asp Arg Phe Leu Val Asn Leu Val Lys Leu Lys His Glu 
545                 550                 555                 560 


Leu Thr Asp Glu Glu Leu Gln Ser Leu Phe Thr Asn Phe Ala Asn Val 
                565                 570                 575     


Val Asp Lys Cys Cys Lys Ala Glu Ser Pro Glu Val Cys Phe Asn Glu 
            580                 585                 590         


Glu Ser Pro Lys Ile Gly Asn 
        595                 


<210>  585
<211>  622
<212>  PRT
<213>  Homo Sapiens

<400>  585

Met Lys Trp Val Glu Ser Ile Phe Leu Ile Phe Leu Leu Asn Phe Thr 
1               5                   10                  15      


Glu Ser Arg Thr Leu His Arg Asn Glu Tyr Gly Ile Ala Ser Ile Leu 
            20                  25                  30          


Asp Ser Tyr Gln Cys Thr Ala Glu Ile Ser Leu Ala Asp Leu Ala Thr 
        35                  40                  45              


Ile Phe Phe Ala Gln Phe Val Gln Glu Ala Thr Tyr Lys Glu Val Ser 
    50                  55                  60                  


Lys Met Val Lys Asp Ala Leu Thr Ala Ile Glu Lys Pro Thr Gly Asp 
65                  70                  75                  80  


Glu Gln Ser Ser Gly Cys Leu Glu Asn Gln Leu Pro Ala Phe Leu Glu 
                85                  90                  95      


Glu Leu Cys His Glu Lys Glu Ile Leu Glu Lys Tyr Gly His Ser Asp 
            100                 105                 110         


Cys Cys Ser Gln Ser Glu Glu Gly Arg His Asn Cys Phe Leu Ala His 
        115                 120                 125             


Lys Lys Pro Thr Pro Ala Ser Ile Pro Leu Phe Gln Val Pro Glu Pro 
    130                 135                 140                 


Val Thr Ser Cys Glu Ala Tyr Glu Glu Asp Arg Glu Thr Phe Met Asn 
145                 150                 155                 160 


Lys Phe Ile Tyr Glu Ile Ala Arg Arg His Pro Phe Leu Tyr Ala Pro 
                165                 170                 175     


Thr Ile Leu Leu Trp Ala Ala Arg Tyr Asp Lys Ile Ile Pro Ser Cys 
            180                 185                 190         


Cys Lys Ala Glu Asn Ala Val Glu Cys Phe Gln Thr Lys Ala Ala Thr 
        195                 200                 205             


Val Thr Lys Glu Leu Arg Glu Ser Ser Leu Leu Asn Gln His Ala Cys 
    210                 215                 220                 


Ala Val Met Lys Asn Phe Gly Thr Arg Thr Phe Gln Ala Ile Thr Val 
225                 230                 235                 240 


Thr Lys Leu Ser Gln Lys Phe Thr Lys Val Asn Phe Thr Glu Ile Gln 
                245                 250                 255     


Lys Leu Val Leu Asp Val Ala His Val His Glu His Cys Cys Arg Gly 
            260                 265                 270         


Asp Val Leu Asp Cys Leu Gln Asp Gly Glu Lys Ile Met Ser Tyr Ile 
        275                 280                 285             


Cys Ser Gln Gln Asp Thr Leu Ser Asn Lys Ile Thr Glu Cys Cys Lys 
    290                 295                 300                 


Leu Thr Thr Leu Glu Arg Gly Gln Cys Ile Ile His Ala Glu Asn Asp 
305                 310                 315                 320 


Glu Lys Pro Glu Gly Leu Ser Pro Asn Leu Asn Arg Phe Leu Gly Asp 
                325                 330                 335     


Arg Asp Phe Asn Gln Phe Ser Ser Gly Glu Lys Asn Ile Phe Leu Ala 
            340                 345                 350         


Ser Phe Val His Glu Tyr Ser Arg Arg His Pro Gln Leu Ala Val Ser 
        355                 360                 365             


Val Ile Leu Arg Val Ala Lys Gly Tyr Gln Glu Leu Leu Glu Lys Cys 
    370                 375                 380                 


Phe Gln Thr Glu Asn Pro Leu Glu Cys Gln Asp Lys Gly Glu Glu Glu 
385                 390                 395                 400 


Leu Gln Lys Tyr Ile Gln Glu Ser Gln Ala Leu Ala Lys Arg Ser Cys 
                405                 410                 415     


Gly Leu Phe Gln Lys Leu Gly Glu Tyr Tyr Leu Gln Asn Ala Phe Leu 
            420                 425                 430         


Val Ala Tyr Thr Lys Lys Ala Pro Gln Leu Thr Ser Ser Glu Leu Met 
        435                 440                 445             


Ala Ile Thr Arg Lys Met Ala Ala Thr Ala Ala Thr Cys Cys Gln Leu 
    450                 455                 460                 


Ser Glu Asp Lys Leu Leu Ala Cys Gly Glu Gly Ala Ala Asp Ile Ile 
465                 470                 475                 480 


Ile Gly His Leu Cys Ile Arg His Glu Met Thr Pro Val Asn Pro Gly 
                485                 490                 495     


Val Gly Gln Cys Cys Thr Ser Ser Tyr Ala Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ser Leu Val Val Asp Glu Thr Tyr Val Pro Pro Ala Phe Ser Asp 
        515                 520                 525             


Asp Lys Phe Ile Phe His Lys Asp Leu Cys Gln Ala Gln Gly Val Ala 
    530                 535                 540                 


Leu Gln Thr Met Lys Gln Glu Phe Leu Ile Asn Leu Val Lys Gln Lys 
545                 550                 555                 560 


Pro Gln Ile Thr Glu Glu Gln Leu Glu Ala Val Ile Ala Asp Phe Ser 
                565                 570                 575     


Gly Leu Leu Glu Lys Cys Cys Gln Gly Gln Glu Gln Glu Val Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Lys Arg Arg Gln Asn Glu Ser Phe Ile Arg Cys Glu 
        595                 600                 605             


Leu Phe Ser Leu Ile Leu Thr Asp Leu Thr Leu Phe Val Asn 
    610                 615                 620         


<210>  586
<211>  609
<212>  PRT
<213>  Homo Sapiens

<400>  586

Met Lys Trp Val Glu Ser Ile Phe Leu Ile Phe Leu Leu Asn Phe Thr 
1               5                   10                  15      


Glu Ser Arg Thr Leu His Arg Asn Glu Tyr Gly Ile Ala Ser Ile Leu 
            20                  25                  30          


Asp Ser Tyr Gln Cys Thr Ala Glu Ile Ser Leu Ala Asp Leu Ala Thr 
        35                  40                  45              


Ile Phe Phe Ala Gln Phe Val Gln Glu Ala Thr Tyr Lys Glu Val Ser 
    50                  55                  60                  


Lys Met Val Lys Asp Ala Leu Thr Ala Ile Glu Lys Pro Thr Gly Asp 
65                  70                  75                  80  


Glu Gln Ser Ser Gly Cys Leu Glu Asn Gln Leu Pro Ala Phe Leu Glu 
                85                  90                  95      


Glu Leu Cys His Glu Lys Glu Ile Leu Glu Lys Tyr Gly His Ser Asp 
            100                 105                 110         


Cys Cys Ser Gln Ser Glu Glu Gly Arg His Asn Cys Phe Leu Ala His 
        115                 120                 125             


Lys Lys Pro Thr Pro Ala Ser Ile Pro Leu Phe Gln Val Pro Glu Pro 
    130                 135                 140                 


Val Thr Ser Cys Glu Ala Tyr Glu Glu Asp Arg Glu Thr Phe Met Asn 
145                 150                 155                 160 


Lys Phe Ile Tyr Glu Ile Ala Arg Arg His Pro Phe Leu Tyr Ala Pro 
                165                 170                 175     


Thr Ile Leu Leu Trp Ala Ala Arg Tyr Asp Lys Ile Ile Pro Ser Cys 
            180                 185                 190         


Cys Lys Ala Glu Asn Ala Val Glu Cys Phe Gln Thr Lys Ala Ala Thr 
        195                 200                 205             


Val Thr Lys Glu Leu Arg Glu Ser Ser Leu Leu Asn Gln His Ala Cys 
    210                 215                 220                 


Ala Val Met Lys Asn Phe Gly Thr Arg Thr Phe Gln Ala Ile Thr Val 
225                 230                 235                 240 


Thr Lys Leu Ser Gln Lys Phe Thr Lys Val Asn Phe Thr Glu Ile Gln 
                245                 250                 255     


Lys Leu Val Leu Asp Val Ala His Val His Glu His Cys Cys Arg Gly 
            260                 265                 270         


Asp Val Leu Asp Cys Leu Gln Asp Gly Glu Lys Ile Met Ser Tyr Ile 
        275                 280                 285             


Cys Ser Gln Gln Asp Thr Leu Ser Asn Lys Ile Thr Glu Cys Cys Lys 
    290                 295                 300                 


Leu Thr Thr Leu Glu Arg Gly Gln Cys Ile Ile His Ala Glu Asn Asp 
305                 310                 315                 320 


Glu Lys Pro Glu Gly Leu Ser Pro Asn Leu Asn Arg Phe Leu Gly Asp 
                325                 330                 335     


Arg Asp Phe Asn Gln Phe Ser Ser Gly Glu Lys Asn Ile Phe Leu Ala 
            340                 345                 350         


Ser Phe Val His Glu Tyr Ser Arg Arg His Pro Gln Leu Ala Val Ser 
        355                 360                 365             


Val Ile Leu Arg Val Ala Lys Gly Tyr Gln Glu Leu Leu Glu Lys Cys 
    370                 375                 380                 


Phe Gln Thr Glu Asn Pro Leu Glu Cys Gln Asp Lys Gly Glu Glu Glu 
385                 390                 395                 400 


Leu Gln Lys Tyr Ile Gln Glu Ser Gln Ala Leu Ala Lys Arg Ser Cys 
                405                 410                 415     


Gly Leu Phe Gln Lys Leu Gly Glu Tyr Tyr Leu Gln Asn Ala Phe Leu 
            420                 425                 430         


Val Ala Tyr Thr Lys Lys Ala Pro Gln Leu Thr Ser Ser Glu Leu Met 
        435                 440                 445             


Ala Ile Thr Arg Lys Met Ala Ala Thr Ala Ala Thr Cys Cys Gln Leu 
    450                 455                 460                 


Ser Glu Asp Lys Leu Leu Ala Cys Gly Glu Gly Ala Ala Asp Ile Ile 
465                 470                 475                 480 


Ile Gly His Leu Cys Ile Arg His Glu Met Thr Pro Val Asn Pro Gly 
                485                 490                 495     


Val Gly Gln Cys Cys Thr Ser Ser Tyr Ala Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ser Leu Val Val Asp Glu Thr Tyr Val Pro Pro Ala Phe Ser Asp 
        515                 520                 525             


Asp Lys Phe Ile Phe His Lys Asp Leu Cys Gln Ala Gln Gly Val Ala 
    530                 535                 540                 


Leu Gln Thr Met Lys Gln Glu Phe Leu Ile Asn Leu Val Lys Gln Lys 
545                 550                 555                 560 


Pro Gln Ile Thr Glu Glu Gln Leu Glu Ala Val Ile Ala Asp Phe Ser 
                565                 570                 575     


Gly Leu Leu Glu Lys Cys Cys Gln Gly Gln Glu Gln Glu Val Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Gln Lys Leu Ile Ser Lys Thr Arg Ala Ala Leu Gly 
        595                 600                 605             


Val 
    


<210>  587
<211>  346
<212>  PRT
<213>  Homo Sapiens

<400>  587

Met Ala Arg Lys Ser Asn Leu Pro Val Leu Leu Val Pro Phe Leu Leu 
1               5                   10                  15      


Cys Gln Ala Leu Val Arg Cys Ser Ser Pro Leu Pro Leu Val Val Asn 
            20                  25                  30          


Thr Trp Pro Phe Lys Asn Ala Thr Glu Ala Ala Trp Arg Ala Leu Ala 
        35                  40                  45              


Ser Gly Gly Ser Ala Leu Asp Ala Val Glu Ser Gly Cys Ala Met Cys 
    50                  55                  60                  


Glu Arg Glu Gln Cys Asp Gly Ser Val Gly Phe Gly Gly Ser Pro Asp 
65                  70                  75                  80  


Glu Leu Gly Glu Thr Thr Leu Asp Ala Met Ile Met Asp Gly Thr Thr 
                85                  90                  95      


Met Asp Val Gly Ala Val Gly Asp Leu Arg Arg Ile Lys Asn Ala Ile 
            100                 105                 110         


Gly Val Ala Arg Lys Val Leu Glu His Thr Thr His Thr Leu Leu Val 
        115                 120                 125             


Gly Glu Ser Ala Thr Thr Phe Ala Gln Ser Met Gly Phe Ile Asn Glu 
    130                 135                 140                 


Asp Leu Ser Thr Thr Ala Ser Gln Ala Leu His Ser Asp Trp Leu Ala 
145                 150                 155                 160 


Arg Asn Cys Gln Pro Asn Tyr Trp Arg Asn Val Ile Pro Asp Pro Ser 
                165                 170                 175     


Lys Tyr Cys Gly Pro Tyr Lys Pro Pro Gly Ile Leu Lys Gln Asp Ile 
            180                 185                 190         


Pro Ile His Lys Glu Thr Glu Asp Asp Arg Gly His Asp Thr Ile Gly 
        195                 200                 205             


Met Val Val Ile His Lys Thr Gly His Ile Ala Ala Gly Thr Ser Thr 
    210                 215                 220                 


Asn Gly Ile Lys Phe Lys Ile His Gly Arg Val Gly Asp Ser Pro Ile 
225                 230                 235                 240 


Pro Gly Ala Gly Ala Tyr Ala Asp Asp Thr Ala Gly Ala Ala Ala Ala 
                245                 250                 255     


Thr Gly Asn Gly Asp Ile Leu Met Arg Phe Leu Pro Ser Tyr Gln Ala 
            260                 265                 270         


Val Glu Tyr Met Arg Arg Gly Glu Asp Pro Thr Ile Ala Cys Gln Lys 
        275                 280                 285             


Val Ile Ser Arg Ile Gln Lys His Phe Pro Glu Phe Phe Gly Ala Val 
    290                 295                 300                 


Ile Cys Ala Asn Val Thr Gly Ser Tyr Gly Ala Ala Cys Asn Lys Leu 
305                 310                 315                 320 


Ser Thr Phe Thr Gln Phe Ser Phe Met Val Tyr Asn Ser Glu Lys Asn 
                325                 330                 335     


Gln Pro Thr Glu Glu Lys Val Asp Cys Ile 
            340                 345     


<210>  588
<211>  155
<212>  PRT
<213>  Homo Sapiens

<400>  588

Arg Lys Val Leu Glu His Thr Thr His Thr Leu Leu Val Gly Glu Ser 
1               5                   10                  15      


Ala Thr Thr Phe Ala Gln Ser Met Gly Phe Ile Asn Glu Asp Leu Ser 
            20                  25                  30          


Thr Thr Ala Ser Gln Ala Leu His Ser Asp Trp Leu Ala Arg Asn Cys 
        35                  40                  45              


Gln Pro Asn Tyr Trp Arg Asn Val Ile Pro Asp Pro Ser Lys Tyr Cys 
    50                  55                  60                  


Gly Pro Tyr Lys Pro Pro Gly Ile Leu Lys Gln Asp Ile Pro Ile His 
65                  70                  75                  80  


Lys Glu Thr Glu Asp Asp Arg Gly His Asp Thr Ile Gly Asp Ser Pro 
                85                  90                  95      


Ile Pro Gly Ala Gly Ala Tyr Ala Asp Asp Thr Ala Gly Ala Ala Ala 
            100                 105                 110         


Ala Thr Gly Asn Gly Asp Ile Leu Met Arg Phe Leu Pro Ser Tyr Gln 
        115                 120                 125             


Ala Val Glu Tyr Met Arg Arg Gly Glu Asp Pro Thr Ile Ala Cys Gln 
    130                 135                 140                 


Lys Val Ile Ser Arg Ile Gln Lys His Phe Pro 
145                 150                 155 


<210>  589
<211>  138
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  589

Xaa Gly Asp Leu Arg Arg Ile Lys Asn Ala Ile Gly Val Ala Arg Lys 
1               5                   10                  15      


Val Leu Glu His Thr Thr His Thr Leu Leu Val Gly Glu Ser Ala Thr 
            20                  25                  30          


Thr Phe Ala Gln Ser Met Gly Phe Ile Asn Glu Asp Leu Ser Thr Thr 
        35                  40                  45              


Ala Ser Gln Ala Leu His Ser Asp Trp Leu Ala Arg Asn Cys Gln Pro 
    50                  55                  60                  


Asn Tyr Trp Arg Asn Val Ile Pro Asp Pro Ser Lys Tyr Cys Gly Pro 
65                  70                  75                  80  


Tyr Lys Pro Pro Gly Ile Leu Lys Gln Asp Ile Pro Ile His Lys Glu 
                85                  90                  95      


Thr Glu Asp Asp Arg Gly His Asp Thr Ile Gly Met Val Val Ile His 
            100                 105                 110         


Lys Thr Gly His Ile Ala Ala Gly Thr Ser Thr Asn Gly Asp Ser Pro 
        115                 120                 125             


Ile Pro Gly Ala Gly Ala Tyr Ala Asp Asp 
    130                 135             


<210>  590
<211>  342
<212>  PRT
<213>  Homo Sapiens

<400>  590

Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val 
    50                  55                  60                  


Leu Pro Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu 
65                  70                  75                  80  


Gly Ile Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys 
                85                  90                  95      


Ser Asn Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile 
            100                 105                 110         


Val Asp Ser Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Gly 
        115                 120                 125             


Thr Cys Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His 
    130                 135                 140                 


Leu Asp Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys 
145                 150                 155                 160 


Glu Gln Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser 
                165                 170                 175     


Glu Leu Met Val Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe 
            180                 185                 190         


Ser Cys Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Thr 
        195                 200                 205             


Ala Pro Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val 
    210                 215                 220                 


Gln Leu Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Thr 
225                 230                 235                 240 


Val Thr Leu Thr Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His 
                245                 250                 255     


Trp Met Lys Asp Val Ser Asp Leu Glu Arg Gly Ala Gly Arg Thr Arg 
            260                 265                 270         


Arg Gly Gly Ala Asn Cys Arg Leu Cys Gly Arg Ile Arg Ala Gly Asn 
        275                 280                 285             


Ser Ser Pro Gly Pro Gly Asp Pro Gly Arg Pro Gly Asp Ser Arg Pro 
    290                 295                 300                 


Ala His Trp Gly His Leu Val Ala Lys Ala Ala Thr Pro Arg Arg Gly 
305                 310                 315                 320 


Glu Glu Gly Pro Arg Lys Pro Gly Gly Arg Gly Gly Ala Cys Arg Thr 
                325                 330                 335     


Glu Ser Val Gly Gly Thr 
            340         


<210>  591
<211>  234
<212>  PRT
<213>  Homo Sapiens

<400>  591

Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn 
            100                 105                 110         


Tyr Arg Ser Leu Arg Thr Phe Thr Ile Thr Ala Ser Asp Trp Ile Phe 
        115                 120                 125             


Pro Pro Ser Glu Ile Pro Gly Lys Pro Glu Ile Val Asp Ser Ala Ser 
    130                 135                 140                 


Glu Leu Thr Ala Gly Val Pro Asn Lys Val Gly Thr Cys Val Ser Glu 
145                 150                 155                 160 


Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp Gly Lys Pro 
                165                 170                 175     


Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln Thr Arg Arg 
            180                 185                 190         


His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu Met Val Thr 
        195                 200                 205             


Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys Ser Phe Ser 
    210                 215                 220                 


Pro Gly Leu Pro Arg His Arg Ala Leu Arg 
225                 230                 


<210>  592
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  592

Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn 
            100                 105                 110         


Tyr Arg Val Arg Val Tyr Gln Phe Glu Asn Leu His Asn Tyr Ser Leu 
        115                 120                 125             


<210>  593
<211>  404
<212>  PRT
<213>  Homo Sapiens

<400>  593

Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn 
            100                 105                 110         


Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp 
        115                 120                 125             


Ser Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Gly Thr Cys 
    130                 135                 140                 


Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp 
145                 150                 155                 160 


Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln 
                165                 170                 175     


Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu 
            180                 185                 190         


Met Val Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys 
        195                 200                 205             


Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Thr Ala Pro 
    210                 215                 220                 


Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu 
225                 230                 235                 240 


Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Thr Val Thr 
                245                 250                 255     


Leu Thr Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met 
            260                 265                 270         


Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu 
        275                 280                 285             


Pro Glu Ile Gly Pro Gln Asp Gln Gly Thr Tyr Ser Cys Val Ala Thr 
    290                 295                 300                 


His Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile 
305                 310                 315                 320 


Ile Glu Pro Gly Glu Glu Gly Pro Thr Ala Gly Ser Val Gly Gly Ser 
                325                 330                 335     


Gly Leu Gly Thr Leu Ala Leu Ala Leu Gly Ile Leu Gly Gly Leu Gly 
            340                 345                 350         


Thr Ala Ala Leu Leu Ile Gly Val Ile Leu Trp Gln Arg Arg Gln Arg 
        355                 360                 365             


Arg Gly Glu Glu Arg Lys Ala Pro Glu Asn Gln Glu Glu Glu Glu Glu 
    370                 375                 380                 


Arg Ala Glu Leu Asn Gln Ser Glu Glu Pro Glu Ala Gly Glu Ser Ser 
385                 390                 395                 400 


Thr Gly Gly Pro 
                


<210>  594
<211>  347
<212>  PRT
<213>  Homo Sapiens

<400>  594

Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn 
            100                 105                 110         


Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp 
        115                 120                 125             


Ser Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Gly Thr Cys 
    130                 135                 140                 


Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp 
145                 150                 155                 160 


Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln 
                165                 170                 175     


Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu 
            180                 185                 190         


Met Val Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys 
        195                 200                 205             


Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Thr Ala Pro 
    210                 215                 220                 


Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu 
225                 230                 235                 240 


Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Thr Val Thr 
                245                 250                 255     


Leu Thr Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met 
            260                 265                 270         


Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu 
        275                 280                 285             


Pro Glu Ile Gly Pro Gln Asp Gln Gly Thr Tyr Ser Cys Val Ala Thr 
    290                 295                 300                 


His Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile 
305                 310                 315                 320 


Ile Glu Pro Gly Glu Glu Gly Pro Thr Ala Gly Glu Gly Phe Asp Lys 
                325                 330                 335     


Val Arg Glu Ala Glu Asp Ser Pro Gln His Met 
            340                 345         


<210>  595
<211>  233
<212>  PRT
<213>  Homo Sapiens

<400>  595

Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn 
            100                 105                 110         


Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp 
        115                 120                 125             


Ser Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Val Glu Glu 
    130                 135                 140                 


Ser Arg Arg Ser Arg Lys Arg Pro Cys Glu Gln Glu Val Gly Thr Cys 
145                 150                 155                 160 


Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp 
                165                 170                 175     


Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln 
            180                 185                 190         


Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu 
        195                 200                 205             


Met Val Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys 
    210                 215                 220                 


Ser Phe Ser Pro Gly Leu Pro Arg His 
225                 230             


<210>  596
<211>  363
<212>  PRT
<213>  Homo Sapiens

<400>  596

Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn 
            100                 105                 110         


Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp 
        115                 120                 125             


Ser Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Val Glu Glu 
    130                 135                 140                 


Ser Arg Arg Ser Arg Lys Arg Pro Cys Glu Gln Glu Val Gly Thr Cys 
145                 150                 155                 160 


Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp 
                165                 170                 175     


Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln 
            180                 185                 190         


Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu 
        195                 200                 205             


Met Val Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys 
    210                 215                 220                 


Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Thr Ala Pro 
225                 230                 235                 240 


Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu 
                245                 250                 255     


Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Thr Val Thr 
            260                 265                 270         


Leu Thr Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met 
        275                 280                 285             


Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu 
    290                 295                 300                 


Pro Glu Ile Gly Pro Gln Asp Gln Gly Thr Tyr Ser Cys Val Ala Thr 
305                 310                 315                 320 


His Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile 
                325                 330                 335     


Ile Glu Pro Gly Glu Glu Gly Pro Thr Ala Gly Glu Gly Phe Asp Lys 
            340                 345                 350         


Val Arg Glu Ala Glu Asp Ser Pro Gln His Met 
        355                 360             


<210>  597
<211>  420
<212>  PRT
<213>  Homo Sapiens

<400>  597

Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn 
            100                 105                 110         


Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp 
        115                 120                 125             


Ser Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Val Glu Glu 
    130                 135                 140                 


Ser Arg Arg Ser Arg Lys Arg Pro Cys Glu Gln Glu Val Gly Thr Cys 
145                 150                 155                 160 


Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp 
                165                 170                 175     


Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln 
            180                 185                 190         


Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu 
        195                 200                 205             


Met Val Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys 
    210                 215                 220                 


Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Thr Ala Pro 
225                 230                 235                 240 


Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu 
                245                 250                 255     


Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Thr Val Thr 
            260                 265                 270         


Leu Thr Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met 
        275                 280                 285             


Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu 
    290                 295                 300                 


Pro Glu Ile Gly Pro Gln Asp Gln Gly Thr Tyr Ser Cys Val Ala Thr 
305                 310                 315                 320 


His Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile 
                325                 330                 335     


Ile Glu Pro Gly Glu Glu Gly Pro Thr Ala Gly Ser Val Gly Gly Ser 
            340                 345                 350         


Gly Leu Gly Thr Leu Ala Leu Ala Leu Gly Ile Leu Gly Gly Leu Gly 
        355                 360                 365             


Thr Ala Ala Leu Leu Ile Gly Val Ile Leu Trp Gln Arg Arg Gln Arg 
    370                 375                 380                 


Arg Gly Glu Glu Arg Lys Ala Pro Glu Asn Gln Glu Glu Glu Glu Glu 
385                 390                 395                 400 


Arg Ala Glu Leu Asn Gln Ser Glu Glu Pro Glu Ala Gly Glu Ser Ser 
                405                 410                 415     


Thr Gly Gly Pro 
            420 


<210>  598
<211>  153
<212>  PRT
<213>  Homo Sapiens

<400>  598

Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Leu Gly Gly Leu Gly Thr Ala Ala Leu Leu Ile Gly Val Ile Leu Trp 
            100                 105                 110         


Gln Arg Arg Gln Arg Arg Gly Glu Glu Arg Lys Ala Pro Glu Asn Gln 
        115                 120                 125             


Glu Glu Glu Glu Glu Arg Ala Glu Leu Asn Gln Ser Glu Glu Pro Glu 
    130                 135                 140                 


Ala Gly Glu Ser Ser Thr Gly Gly Pro 
145                 150             


<210>  599
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  599

Met Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile 
1               5                   10                  15      


Leu Pro Glu Ile Gly Pro Gln Asp Gln Gly Thr Tyr Ser Cys Val Ala 
            20                  25                  30          


Thr His Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser 
        35                  40                  45              


Ile Ile Glu Pro Gly Glu Glu Gly Pro Thr Ala Gly Ser Val Gly Gly 
    50                  55                  60                  


Ser Gly Leu Gly Thr Leu Ala Leu Ala Leu Gly Ile Leu Gly Gly Leu 
65                  70                  75                  80  


Gly Thr Ala Ala Leu Leu Ile Gly Val Ile Leu Trp Gln Arg Arg Gln 
                85                  90                  95      


Arg Arg Gly Glu Glu Arg Lys Ala Pro Glu Asn Gln Glu Glu Glu Glu 
            100                 105                 110         


Glu Arg Ala Glu Leu Asn Gln Ser Glu Glu Pro Glu Ala Gly Glu Ser 
        115                 120                 125             


Ser Thr Gly Gly Pro 
    130             


<210>  600
<211>  294
<212>  PRT
<213>  Homo Sapiens

<400>  600

Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn Tyr Arg Val Arg Val 
1               5                   10                  15      


Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp Ser Ala Ser Glu Leu 
            20                  25                  30          


Thr Ala Gly Val Pro Asn Lys Val Gly Thr Cys Val Ser Glu Gly Ser 
        35                  40                  45              


Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp Gly Lys Pro Leu Val 
    50                  55                  60                  


Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln Thr Arg Arg His Pro 
65                  70                  75                  80  


Glu Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu Met Val Thr Pro Ala 
                85                  90                  95      


Arg Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys Ser Phe Ser Pro Gly 
            100                 105                 110         


Leu Pro Arg His Arg Ala Leu Arg Thr Ala Pro Ile Gln Pro Arg Val 
        115                 120                 125             


Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu Val Val Glu Pro Glu 
    130                 135                 140                 


Gly Gly Ala Val Ala Pro Gly Gly Thr Val Thr Leu Thr Cys Glu Val 
145                 150                 155                 160 


Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met Lys Asp Gly Val Pro 
                165                 170                 175     


Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu Pro Glu Ile Gly Pro 
            180                 185                 190         


Gln Asp Gln Gly Thr Tyr Ser Cys Val Ala Thr His Ser Ser His Gly 
        195                 200                 205             


Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile Ile Gly Ser Val Gly 
    210                 215                 220                 


Gly Ser Gly Leu Gly Thr Leu Ala Leu Ala Leu Gly Ile Leu Gly Gly 
225                 230                 235                 240 


Leu Gly Thr Ala Ala Leu Leu Ile Gly Val Ile Leu Trp Gln Arg Arg 
                245                 250                 255     


Gln Arg Arg Gly Glu Glu Arg Lys Ala Pro Glu Asn Gln Glu Glu Glu 
            260                 265                 270         


Glu Glu Arg Ala Glu Leu Asn Gln Ser Glu Glu Pro Glu Ala Gly Glu 
        275                 280                 285             


Ser Ser Thr Gly Gly Pro 
    290                 


<210>  601
<211>  394
<212>  PRT
<213>  Homo Sapiens

<400>  601

Met Glu Asn Thr Asp Ser Asp Asn Leu Leu Arg Arg Ala Ala Cys Gln 
1               5                   10                  15      


Glu Ala Gln Val Phe Gly Asn Gln Leu Ile Pro Pro Asn Ala Gln Val 
            20                  25                  30          


Lys Lys Ala Thr Val Phe Leu Asn Pro Ala Ala Cys Lys Gly Lys Ala 
        35                  40                  45              


Arg Thr Leu Phe Glu Lys Asn Ala Ala Pro Ile Leu His Leu Ser Gly 
    50                  55                  60                  


Met Asp Val Thr Ile Val Lys Thr Asp Tyr Glu Gly Gln Ala Lys Lys 
65                  70                  75                  80  


Leu Leu Glu Leu Met Glu Asn Thr Asp Val Ile Ile Val Ala Gly Gly 
                85                  90                  95      


Asp Gly Thr Leu Gln Glu Val Val Thr Gly Val Leu Arg Arg Thr Asp 
            100                 105                 110         


Glu Ala Thr Phe Ser Lys Ile Pro Ile Gly Phe Ile Pro Leu Gly Glu 
        115                 120                 125             


Thr Ser Ser Leu Ser His Thr Leu Phe Ala Glu Ser Gly Asn Lys Val 
    130                 135                 140                 


Gln His Ile Thr Asp Ala Thr Leu Ala Ile Val Lys Gly Glu Thr Val 
145                 150                 155                 160 


Pro Leu Asp Val Leu Gln Ile Lys Gly Glu Lys Glu Gln Pro Val Phe 
                165                 170                 175     


Ala Met Thr Gly Leu Arg Trp Gly Ser Phe Arg Asp Ala Gly Val Lys 
            180                 185                 190         


Val Ser Lys Tyr Trp Tyr Leu Gly Pro Leu Lys Ile Lys Ala Ala His 
        195                 200                 205             


Phe Phe Ser Thr Leu Lys Glu Trp Pro Gln Thr His Gln Ala Ser Ile 
    210                 215                 220                 


Ser Tyr Thr Gly Pro Thr Glu Arg Pro Pro Asn Glu Pro Glu Glu Thr 
225                 230                 235                 240 


Pro Val Gln Arg Pro Ser Leu Tyr Arg Arg Ile Leu Arg Arg Leu Ala 
                245                 250                 255     


Ser Tyr Trp Ala Gln Pro Gln Asp Ala Leu Ser Gln Glu Val Ser Pro 
            260                 265                 270         


Glu Val Trp Lys Asp Val Gln Leu Ser Thr Ile Glu Leu Ser Ile Thr 
        275                 280                 285             


Thr Arg Asn Asn Gln Leu Asp Pro Thr Ser Lys Glu Asp Phe Leu Asn 
    290                 295                 300                 


Ile Cys Ile Glu Pro Asp Thr Ile Ser Lys Gly Asp Phe Ile Thr Ile 
305                 310                 315                 320 


Gly Ser Arg Lys Val Arg Asn Pro Lys Leu His Val Glu Gly Thr Glu 
                325                 330                 335     


Cys Leu Gln Ala Ser Gln Cys Thr Leu Leu Ile Pro Glu Gly Ala Gly 
            340                 345                 350         


Gly Ser Phe Ser Ile Asp Ser Glu Glu Tyr Glu Ala Met Pro Val Glu 
        355                 360                 365             


Val Lys Leu Leu Pro Arg Lys Leu Gln Phe Phe Cys Asp Pro Arg Lys 
    370                 375                 380                 


Arg Glu Gln Met Leu Thr Ser Pro Thr Gln 
385                 390                 


<210>  602
<211>  65
<212>  PRT
<213>  Homo Sapiens

<400>  602

Met Thr Val Phe Phe Lys Thr Leu Arg Asn His Trp Lys Lys Thr Thr 
1               5                   10                  15      


Ala Gly Leu Cys Leu Leu Thr Trp Gly Gly His Trp Leu Tyr Gly Lys 
            20                  25                  30          


His Cys Asp Asn Leu Leu Arg Arg Ala Ala Cys Gln Glu Ala Gln His 
        35                  40                  45              


Tyr Gln Asp Glu Ser Arg Trp Glu Pro Thr Leu Ser Arg Thr Pro Gly 
    50                  55                  60                  


Ser 
65  


<210>  603
<211>  422
<212>  PRT
<213>  Homo Sapiens

<400>  603

Met Thr Val Phe Phe Lys Thr Leu Arg Asn His Trp Lys Lys Thr Thr 
1               5                   10                  15      


Ala Gly Leu Cys Leu Leu Thr Trp Gly Gly His Trp Leu Tyr Gly Lys 
            20                  25                  30          


His Cys Asp Asn Leu Leu Arg Arg Ala Ala Cys Gln Glu Ala Gln Val 
        35                  40                  45              


Phe Gly Asn Gln Leu Ile Pro Pro Asn Ala Gln Val Lys Lys Ala Thr 
    50                  55                  60                  


Val Phe Leu Asn Pro Ala Ala Cys Lys Gly Lys Ala Arg Thr Leu Phe 
65                  70                  75                  80  


Glu Lys Asn Ala Ala Pro Ile Leu His Leu Ser Gly Met Asp Val Thr 
                85                  90                  95      


Ile Val Lys Thr Asp Tyr Glu Gly Gln Ala Lys Lys Leu Leu Glu Leu 
            100                 105                 110         


Met Glu Asn Thr Asp Val Ile Ile Val Ala Gly Gly Asp Gly Thr Leu 
        115                 120                 125             


Gln Glu Val Val Thr Gly Val Leu Arg Arg Thr Asp Glu Ala Thr Phe 
    130                 135                 140                 


Ser Lys Ile Pro Ile Gly Phe Ile Pro Leu Gly Glu Thr Ser Ser Leu 
145                 150                 155                 160 


Ser His Thr Leu Phe Ala Glu Ser Gly Asn Lys Val Gln His Ile Thr 
                165                 170                 175     


Asp Ala Thr Leu Ala Ile Val Lys Gly Glu Thr Val Pro Leu Asp Val 
            180                 185                 190         


Leu Gln Ile Lys Gly Glu Lys Glu Gln Pro Val Phe Ala Met Thr Gly 
        195                 200                 205             


Leu Arg Trp Gly Ser Phe Arg Asp Ala Gly Val Lys Val Ser Lys Tyr 
    210                 215                 220                 


Trp Tyr Leu Gly Pro Leu Lys Ile Lys Ala Ala His Phe Phe Ser Thr 
225                 230                 235                 240 


Leu Lys Glu Trp Pro Gln Thr His Gln Ala Ser Ile Ser Tyr Thr Gly 
                245                 250                 255     


Pro Thr Glu Arg Pro Pro Asn Glu Pro Glu Glu Thr Pro Val Gln Arg 
            260                 265                 270         


Pro Ser Leu Tyr Arg Arg Ile Leu Arg Arg Leu Ala Ser Tyr Trp Ala 
        275                 280                 285             


Gln Pro Gln Asp Ala Leu Ser Gln Glu Val Ser Pro Glu Val Trp Lys 
    290                 295                 300                 


Asp Val Gln Leu Ser Thr Ile Glu Leu Ser Ile Thr Thr Arg Asn Asn 
305                 310                 315                 320 


Gln Leu Asp Pro Thr Ser Lys Glu Asp Phe Leu Asn Ile Cys Ile Glu 
                325                 330                 335     


Pro Asp Thr Ile Ser Lys Gly Asp Phe Ile Thr Ile Gly Ser Arg Lys 
            340                 345                 350         


Val Arg Asn Pro Lys Leu His Val Glu Gly Thr Glu Cys Leu Gln Ala 
        355                 360                 365             


Ser Gln Cys Thr Leu Leu Ile Pro Glu Gly Ala Gly Gly Ser Phe Ser 
    370                 375                 380                 


Ile Asp Ser Glu Glu Tyr Glu Ala Met Pro Val Glu Val Lys Leu Leu 
385                 390                 395                 400 


Pro Arg Lys Leu Gln Phe Phe Cys Asp Pro Arg Lys Arg Glu Gln Met 
                405                 410                 415     


Leu Thr Ser Pro Thr Gln 
            420         


<210>  604
<211>  244
<212>  PRT
<213>  Homo Sapiens

<400>  604

Met Thr Val Phe Phe Lys Thr Leu Arg Asn His Trp Lys Lys Thr Thr 
1               5                   10                  15      


Ala Gly Leu Cys Leu Leu Thr Trp Gly Gly His Trp Leu Tyr Gly Lys 
            20                  25                  30          


His Cys Asp Asn Leu Leu Arg Arg Ala Ala Cys Gln Glu Ala Gln Val 
        35                  40                  45              


Phe Gly Asn Gln Leu Ile Pro Pro Asn Ala Gln Val Lys Lys Ala Thr 
    50                  55                  60                  


Val Phe Leu Asn Pro Ala Ala Cys Lys Gly Thr Leu Phe Glu Lys Asn 
65                  70                  75                  80  


Ala Ala Pro Ile Leu His Leu Ser Gly Met Asp Val Thr Ile Val Lys 
                85                  90                  95      


Thr Asp Tyr Glu Gly Gln Ala Lys Lys Leu Leu Glu Leu Met Glu Asn 
            100                 105                 110         


Thr Asp Val Ile Ile Val Ala Gly Gly Asp Gly Thr Leu Gln Glu Val 
        115                 120                 125             


Val Thr Gly Val Leu Arg Arg Thr Asp Glu Ala Thr Phe Ser Lys Ile 
    130                 135                 140                 


Pro Ile Gly Phe Ile Pro Leu Gly Glu Thr Ser Ser Leu Ser His Thr 
145                 150                 155                 160 


Leu Phe Ala Glu Ser Gly Asn Lys Val Gln His Ile Thr Asp Ala Thr 
                165                 170                 175     


Leu Ala Ile Val Lys Gly Glu Thr Val Pro Leu Asp Val Leu Gln Ile 
            180                 185                 190         


Lys Gly Glu Lys Glu Gln Pro Val Phe Ala Met Thr Gly Leu Arg Trp 
        195                 200                 205             


Gly Ser Phe Arg Asp Ala Gly Val Lys Val Ser Lys Tyr Trp Tyr Leu 
    210                 215                 220                 


Gly Pro Leu Lys Ile Lys Ala Ala His Phe Phe Ser Thr Leu Lys Pro 
225                 230                 235                 240 


Phe Pro Lys Arg 
                


<210>  605
<211>  244
<212>  PRT
<213>  Homo Sapiens

<400>  605

Met Thr Val Phe Phe Lys Thr Leu Arg Asn His Trp Lys Lys Thr Thr 
1               5                   10                  15      


Ala Gly Leu Cys Leu Leu Thr Trp Gly Gly His Trp Leu Tyr Gly Lys 
            20                  25                  30          


His Cys Asp Asn Leu Leu Arg Arg Ala Ala Cys Gln Glu Ala Gln Val 
        35                  40                  45              


Phe Gly Asn Gln Leu Ile Pro Pro Asn Ala Gln Val Lys Lys Ala Thr 
    50                  55                  60                  


Val Phe Leu Asn Pro Ala Ala Cys Lys Gly Thr Leu Phe Glu Lys Asn 
65                  70                  75                  80  


Ala Ala Pro Ile Leu His Leu Ser Gly Met Asp Val Thr Ile Val Lys 
                85                  90                  95      


Thr Asp Tyr Glu Gly Gln Ala Lys Lys Leu Leu Glu Leu Met Glu Asn 
            100                 105                 110         


Thr Asp Val Ile Ile Val Ala Gly Gly Asp Gly Thr Leu Gln Glu Val 
        115                 120                 125             


Val Thr Gly Val Leu Arg Arg Thr Asp Glu Ala Thr Phe Ser Lys Ile 
    130                 135                 140                 


Pro Ile Gly Phe Ile Pro Leu Gly Glu Thr Ser Ser Leu Ser His Thr 
145                 150                 155                 160 


Leu Phe Ala Glu Ser Gly Asn Lys Val Gln His Ile Thr Asp Ala Thr 
                165                 170                 175     


Leu Ala Ile Val Lys Gly Glu Thr Val Pro Leu Asp Val Leu Gln Ile 
            180                 185                 190         


Lys Gly Glu Lys Glu Gln Pro Val Phe Ala Met Thr Gly Leu Arg Trp 
        195                 200                 205             


Gly Ser Phe Arg Asp Ala Gly Val Lys Val Ser Lys Tyr Trp Tyr Leu 
    210                 215                 220                 


Gly Pro Leu Lys Ile Lys Ala Ala His Phe Phe Ser Thr Leu Lys Pro 
225                 230                 235                 240 


Phe Pro Lys Arg 
                


<210>  606
<211>  46
<212>  PRT
<213>  Homo Sapiens

<400>  606

Met Thr Val Phe Phe Lys Thr Leu Arg Asn His Trp Lys Lys Thr Thr 
1               5                   10                  15      


Ala Gly Leu Cys Leu Leu Thr Trp Gly Gly His Trp Leu Tyr Gly Lys 
            20                  25                  30          


His Trp Cys Leu Ala Ile Asn Ser Phe Leu Pro Met His Lys 
        35                  40                  45      


<210>  607
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  607

Met Ala Glu Ala Ala Ala Ala Ala Gly Gly Thr Gly Leu Gly Ala Gly 
1               5                   10                  15      


Ala Ser Tyr Gly Ser Ala Ala Asp Arg Asp Arg Asp Pro Asp Pro Asp 
            20                  25                  30          


Arg Ala Gly Arg Arg Leu Arg Val Leu Ser Gly His Leu Leu Gly Arg 
        35                  40                  45              


Pro Arg Glu Ala Leu Ser Thr Asn Glu Cys Lys Ala Arg Arg Ala Ala 
    50                  55                  60                  


Ser Ala Ala Thr Ala Ala Pro Thr Ala Thr Pro Ala Ala Gln Glu Ser 
65                  70                  75                  80  


Gly Thr Ile Pro Lys Lys Arg Gln Glu Val Met Lys Trp Asn Gly Trp 
                85                  90                  95      


Gly Tyr Asn Asp Ser Lys Phe Ile Phe Asn Lys Lys Gly Gln Ile Glu 
            100                 105                 110         


Leu Thr Gly Lys Arg Gly Ile Ser Asp Pro Leu Thr Val Phe Glu Gln 
        115                 120                 125             


Thr Glu Ala Ala Ala Arg Glu Glu Ile Leu Ala Asn Gly Gly Ser Leu 
    130                 135                 140                 


Ser His His His Gly Val Gly Lys Leu Arg Lys Gln Trp Leu Lys Glu 
145                 150                 155                 160 


Ser Ile Ser Asp Val Gly Phe Gly Met Leu Lys Ser Val Lys Glu Tyr 
                165                 170                 175     


Val Asp Pro Asn Asn Ile Phe Gly Asn Arg Asn Leu Leu 
            180                 185                 


<210>  608
<211>  658
<212>  PRT
<213>  Homo Sapiens

<400>  608

Met Ala Glu Ala Ala Ala Ala Ala Gly Gly Thr Gly Leu Gly Ala Gly 
1               5                   10                  15      


Ala Ser Tyr Gly Ser Ala Ala Asp Arg Asp Arg Asp Pro Asp Pro Asp 
            20                  25                  30          


Arg Ala Gly Arg Arg Leu Arg Val Leu Ser Gly His Leu Leu Gly Arg 
        35                  40                  45              


Pro Arg Glu Ala Leu Ser Thr Asn Glu Cys Lys Ala Arg Arg Ala Ala 
    50                  55                  60                  


Ser Ala Ala Thr Ala Ala Pro Thr Ala Thr Pro Ala Ala Gln Glu Ser 
65                  70                  75                  80  


Gly Thr Ile Pro Lys Lys Arg Gln Glu Val Met Lys Trp Asn Gly Trp 
                85                  90                  95      


Gly Tyr Asn Asp Ser Lys Phe Ile Phe Asn Lys Lys Gly Gln Ile Glu 
            100                 105                 110         


Leu Thr Gly Lys Arg Tyr Pro Leu Ser Gly Met Gly Leu Pro Thr Phe 
        115                 120                 125             


Lys Glu Trp Ile Gln Asn Thr Leu Gly Val Asn Val Glu His Lys Thr 
    130                 135                 140                 


Thr Ser Lys Ala Ser Leu Asn Pro Ser Asp Thr Pro Pro Ser Val Val 
145                 150                 155                 160 


Asn Glu Asp Phe Leu His Asp Leu Lys Glu Thr Asn Ile Ser Tyr Ser 
                165                 170                 175     


Gln Glu Ala Asp Asp Arg Val Phe Arg Ala His Gly His Cys Leu His 
            180                 185                 190         


Glu Ile Phe Leu Leu Arg Glu Gly Met Phe Glu Arg Ile Pro Asp Ile 
        195                 200                 205             


Val Leu Trp Pro Thr Cys His Asp Asp Val Val Lys Ile Val Asn Leu 
    210                 215                 220                 


Ala Cys Lys Tyr Asn Leu Cys Ile Ile Pro Ile Gly Gly Gly Thr Ser 
225                 230                 235                 240 


Val Ser Tyr Gly Leu Met Cys Pro Ala Asp Glu Thr Arg Thr Ile Ile 
                245                 250                 255     


Ser Leu Asp Thr Ser Gln Met Asn Arg Ile Leu Trp Val Asp Glu Asn 
            260                 265                 270         


Asn Leu Thr Ala His Val Glu Ala Gly Ile Thr Gly Gln Glu Leu Glu 
        275                 280                 285             


Arg Gln Leu Lys Glu Ser Gly Tyr Cys Thr Gly His Glu Pro Asp Ser 
    290                 295                 300                 


Leu Glu Phe Ser Thr Val Gly Gly Trp Val Ser Thr Arg Ala Ser Gly 
305                 310                 315                 320 


Met Lys Lys Asn Ile Tyr Gly Asn Ile Glu Asp Leu Val Val His Ile 
                325                 330                 335     


Lys Met Val Thr Pro Arg Gly Ile Ile Glu Lys Ser Cys Gln Gly Pro 
            340                 345                 350         


Arg Met Ser Thr Gly Pro Asp Ile His His Phe Ile Met Gly Ser Glu 
        355                 360                 365             


Gly Thr Leu Gly Val Ile Thr Glu Ala Thr Ile Lys Ile Arg Pro Val 
    370                 375                 380                 


Pro Glu Tyr Gln Lys Tyr Gly Ser Val Ala Phe Pro Asn Phe Glu Gln 
385                 390                 395                 400 


Gly Val Ala Cys Leu Arg Glu Ile Ala Lys Gln Arg Cys Ala Pro Ala 
                405                 410                 415     


Ser Ile Arg Leu Met Asp Asn Lys Gln Phe Gln Phe Gly His Ala Leu 
            420                 425                 430         


Lys Pro Gln Val Ser Ser Ile Phe Thr Ser Phe Leu Asp Gly Leu Lys 
        435                 440                 445             


Lys Phe Tyr Ile Thr Lys Phe Lys Gly Phe Asp Pro Asn Gln Leu Ser 
    450                 455                 460                 


Val Ala Thr Leu Leu Phe Glu Gly Asp Arg Glu Lys Val Leu Gln His 
465                 470                 475                 480 


Glu Lys Gln Val Tyr Asp Ile Ala Ala Lys Phe Gly Gly Leu Ala Ala 
                485                 490                 495     


Gly Glu Asp Asn Gly Gln Arg Gly Tyr Leu Leu Thr Tyr Val Ile Ala 
            500                 505                 510         


Tyr Ile Arg Asp Leu Ala Leu Glu Tyr Tyr Val Leu Gly Glu Ser Phe 
        515                 520                 525             


Glu Thr Ser Ala Pro Trp Asp Arg Val Val Asp Leu Cys Arg Asn Val 
    530                 535                 540                 


Lys Glu Arg Ile Thr Arg Glu Cys Lys Glu Lys Gly Val Gln Phe Ala 
545                 550                 555                 560 


Pro Phe Ser Thr Cys Arg Val Thr Gln Thr Tyr Asp Ala Gly Ala Cys 
                565                 570                 575     


Ile Tyr Phe Tyr Phe Ala Phe Asn Tyr Arg Gly Ile Ser Asp Pro Leu 
            580                 585                 590         


Thr Val Phe Glu Gln Thr Glu Ala Ala Ala Arg Glu Glu Ile Leu Ala 
        595                 600                 605             


Asn Gly Gly Ser Leu Ser His His His Gly Val Gly Lys Leu Arg Lys 
    610                 615                 620                 


Gln Trp Leu Lys Glu Ser Ile Ser Asp Val Gly Phe Gly Met Leu Lys 
625                 630                 635                 640 


Ser Val Lys Glu Tyr Val Asp Pro Asn Asn Ile Phe Gly Asn Arg Asn 
                645                 650                 655     


Leu Leu 
        


<210>  609
<211>  543
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  609

Xaa Gln Glu Val Met Lys Trp Asn Gly Trp Gly Tyr Asn Asp Ser Lys 
1               5                   10                  15      


Phe Ile Phe Asn Lys Lys Gly Gln Ile Glu Leu Thr Gly Lys Arg Tyr 
            20                  25                  30          


Pro Leu Ser Gly Met Gly Leu Pro Thr Phe Lys Glu Trp Ile Gln Asn 
        35                  40                  45              


Thr Leu Gly Val Asn Val Glu His Lys Thr Thr Ser Lys Ala Ser Leu 
    50                  55                  60                  


Asn Pro Ser Asp Thr Pro Pro Ser Val Val Asn Glu Asp Phe Leu His 
65                  70                  75                  80  


Asp Leu Lys Glu Thr Asn Ile Ser Tyr Ser Gln Glu Ala Asp Asp Arg 
                85                  90                  95      


Val Phe Arg Ala His Gly His Cys Leu His Glu Ile Phe Leu Leu Arg 
            100                 105                 110         


Glu Gly Met Phe Glu Arg Ile Pro Asp Ile Val Leu Trp Pro Thr Cys 
        115                 120                 125             


His Asp Asp Val Val Lys Ile Val Asn Leu Ala Cys Lys Tyr Asn Leu 
    130                 135                 140                 


Cys Ile Ile Pro Ile Gly Gly Gly Thr Ser Val Ser Tyr Gly Leu Met 
145                 150                 155                 160 


Cys Pro Ala Asp Glu Thr Arg Thr Ile Ile Ser Leu Asp Thr Ser Gln 
                165                 170                 175     


Met Asn Arg Ile Leu Trp Val Asp Glu Asn Asn Leu Thr Ala His Val 
            180                 185                 190         


Glu Ala Gly Ile Thr Gly Gln Glu Leu Glu Arg Gln Leu Lys Glu Ser 
        195                 200                 205             


Gly Tyr Cys Thr Gly His Glu Pro Asp Ser Leu Glu Phe Ser Thr Val 
    210                 215                 220                 


Gly Gly Trp Val Ser Thr Arg Ala Ser Gly Met Lys Lys Asn Ile Tyr 
225                 230                 235                 240 


Gly Asn Ile Glu Asp Leu Val Val His Ile Lys Met Val Thr Pro Arg 
                245                 250                 255     


Gly Ile Ile Glu Lys Ser Cys Gln Gly Pro Arg Met Ser Thr Gly Pro 
            260                 265                 270         


Asp Ile His His Phe Ile Met Gly Ser Glu Gly Thr Leu Gly Val Ile 
        275                 280                 285             


Thr Glu Ala Thr Ile Lys Ile Arg Pro Val Pro Glu Tyr Gln Lys Tyr 
    290                 295                 300                 


Gly Ser Val Ala Phe Pro Asn Phe Glu Gln Gly Val Ala Cys Leu Arg 
305                 310                 315                 320 


Glu Ile Ala Lys Gln Arg Cys Ala Pro Ala Ser Ile Arg Leu Met Asp 
                325                 330                 335     


Asn Lys Gln Phe Gln Phe Gly His Ala Leu Lys Pro Gln Val Ser Ser 
            340                 345                 350         


Ile Phe Thr Ser Phe Leu Asp Gly Leu Lys Lys Phe Tyr Ile Thr Lys 
        355                 360                 365             


Phe Lys Gly Phe Asp Pro Asn Gln Leu Ser Val Ala Thr Leu Leu Phe 
    370                 375                 380                 


Glu Gly Asp Arg Glu Lys Val Leu Gln His Glu Lys Gln Val Tyr Asp 
385                 390                 395                 400 


Ile Ala Ala Lys Phe Gly Gly Leu Ala Ala Gly Glu Asp Asn Gly Gln 
                405                 410                 415     


Arg Gly Tyr Leu Leu Thr Tyr Val Ile Ala Tyr Ile Arg Asp Leu Ala 
            420                 425                 430         


Leu Glu Tyr Tyr Val Leu Gly Glu Ser Phe Glu Thr Ser Ala Pro Trp 
        435                 440                 445             


Asp Arg Val Val Asp Leu Cys Arg Asn Val Lys Glu Arg Ile Thr Arg 
    450                 455                 460                 


Glu Cys Lys Glu Lys Gly Val Gln Phe Ala Pro Phe Ser Thr Cys Arg 
465                 470                 475                 480 


Val Thr Gln Thr Tyr Asp Ala Gly Ala Cys Ile Tyr Phe Tyr Phe Ala 
                485                 490                 495     


Phe Asn Tyr Arg Gly Ile Ser Asp Pro Leu Thr Val Phe Glu Gln Thr 
            500                 505                 510         


Glu Ala Ala Ala Arg Glu Glu Ile Leu Ala Asn Gly Gly Ser Leu Ser 
        515                 520                 525             


His His His Gly Gly Leu Gln Leu Glu Gly Thr Cys Tyr Glu Ser 
    530                 535                 540             


<210>  610
<211>  560
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  610

Xaa Tyr Pro Leu Ser Gly Met Gly Leu Pro Thr Phe Lys Glu Trp Ile 
1               5                   10                  15      


Gln Asn Thr Leu Gly Val Asn Val Glu His Lys Thr Thr Ser Lys Ala 
            20                  25                  30          


Ser Leu Asn Pro Ser Asp Thr Pro Pro Ser Val Val Asn Glu Asp Phe 
        35                  40                  45              


Leu His Asp Leu Lys Glu Thr Asn Ile Ser Tyr Ser Gln Glu Ala Asp 
    50                  55                  60                  


Asp Arg Val Phe Arg Ala His Gly His Cys Leu His Glu Ile Phe Leu 
65                  70                  75                  80  


Leu Arg Glu Gly Met Phe Glu Arg Ile Pro Asp Ile Val Leu Trp Pro 
                85                  90                  95      


Thr Cys His Asp Asp Val Val Lys Ile Val Asn Leu Ala Cys Lys Tyr 
            100                 105                 110         


Asn Leu Cys Ile Ile Pro Ile Gly Gly Gly Thr Ser Val Ser Tyr Gly 
        115                 120                 125             


Leu Met Cys Pro Ala Asp Glu Thr Arg Thr Ile Ile Ser Leu Asp Thr 
    130                 135                 140                 


Ser Gln Met Asn Arg Ile Leu Trp Val Asp Glu Asn Asn Leu Thr Ala 
145                 150                 155                 160 


His Val Glu Ala Gly Ile Thr Gly Gln Glu Leu Glu Arg Gln Leu Lys 
                165                 170                 175     


Glu Ser Gly Tyr Cys Thr Gly His Glu Pro Asp Ser Leu Glu Phe Ser 
            180                 185                 190         


Thr Val Gly Gly Trp Val Ser Thr Arg Ala Ser Gly Met Lys Lys Asn 
        195                 200                 205             


Ile Tyr Gly Asn Ile Glu Asp Leu Val Val His Ile Lys Met Val Thr 
    210                 215                 220                 


Pro Arg Gly Ile Ile Glu Lys Ser Cys Gln Gly Pro Arg Met Ser Thr 
225                 230                 235                 240 


Gly Pro Asp Ile His His Phe Ile Met Gly Ser Glu Gly Thr Leu Gly 
                245                 250                 255     


Val Ile Thr Glu Ala Thr Ile Lys Ile Arg Pro Val Pro Glu Tyr Gln 
            260                 265                 270         


Lys Tyr Gly Ser Val Ala Phe Pro Asn Phe Glu Gln Gly Val Ala Cys 
        275                 280                 285             


Leu Arg Glu Ile Ala Lys Gln Arg Cys Ala Pro Ala Ser Ile Arg Leu 
    290                 295                 300                 


Met Asp Asn Lys Gln Phe Gln Phe Gly His Ala Leu Lys Pro Gln Val 
305                 310                 315                 320 


Ser Ser Ile Phe Thr Ser Phe Leu Asp Gly Leu Lys Lys Phe Tyr Ile 
                325                 330                 335     


Thr Lys Phe Lys Gly Phe Asp Pro Asn Gln Leu Ser Val Ala Thr Leu 
            340                 345                 350         


Leu Phe Glu Gly Asp Arg Glu Lys Val Leu Gln His Glu Lys Gln Val 
        355                 360                 365             


Tyr Asp Ile Ala Ala Lys Phe Gly Gly Leu Ala Ala Gly Glu Asp Asn 
    370                 375                 380                 


Gly Gln Arg Gly Tyr Leu Leu Thr Tyr Val Ile Ala Tyr Ile Arg Asp 
385                 390                 395                 400 


Leu Ala Leu Glu Tyr Tyr Val Leu Gly Glu Ser Phe Glu Thr Ser Ala 
                405                 410                 415     


Pro Trp Asp Arg Val Val Asp Leu Cys Arg Asn Val Lys Glu Arg Ile 
            420                 425                 430         


Thr Arg Glu Cys Lys Glu Lys Gly Val Gln Phe Ala Pro Phe Ser Thr 
        435                 440                 445             


Cys Arg Val Thr Gln Thr Tyr Asp Ala Gly Ala Cys Ile Tyr Phe Tyr 
    450                 455                 460                 


Phe Ala Phe Asn Tyr Arg Gly Ile Ser Asp Pro Leu Thr Val Phe Glu 
465                 470                 475                 480 


Gln Thr Glu Ala Ala Ala Arg Glu Glu Ile Leu Ala Asn Gly Gly Ser 
                485                 490                 495     


Leu Ser His His His Gly Glu His Glu Pro His Ser Thr Ser Thr His 
            500                 505                 510         


His Gly Arg Tyr Arg Ile Pro Gln Ile Cys Gly Arg Ser Phe Pro Pro 
        515                 520                 525             


Leu Asp Asn Phe Gln Asp Ser Ser Arg Phe Leu Pro Glu Pro Ser Thr 
    530                 535                 540                 


Gln Glu Cys Ile Ser Pro Trp Phe His His Ile His Ser Leu Pro Phe 
545                 550                 555                 560 


<210>  611
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  611

Met Glu Lys Ile Pro Val Ser Ala Phe Leu Leu Leu Val Ala Leu Ser 
1               5                   10                  15      


Tyr Thr Leu Ala Arg Asp Thr Thr Val Lys Pro Gly Ala Lys Lys Asp 
            20                  25                  30          


Thr Lys Asp Ser Arg Pro Lys Leu Pro Gln Thr Leu Ser Arg Gly Trp 
        35                  40                  45              


Gly Asp Gln Leu Ile Trp Thr Gln Thr Tyr Glu Glu Ala Leu Tyr Lys 
    50                  55                  60                  


Ser Lys Thr Ser Asn Lys Pro Leu Met Ile Ile His His Leu Asp Glu 
65                  70                  75                  80  


Cys Pro His Ser Gln Ala Leu Lys Lys Val Phe Ala Glu Asn Lys Glu 
                85                  90                  95      


Ile Gln Lys Leu Ala Glu Gln Phe Val Leu Leu Asn Leu Val Tyr Glu 
            100                 105                 110         


Thr Thr Asp Lys His Leu Ser Pro Asp Gly Gln Tyr Val Pro Arg Ile 
        115                 120                 125             


Met Phe Val 
    130     


<210>  612
<211>  188
<212>  PRT
<213>  Homo Sapiens

<400>  612

Met Glu Lys Ile Pro Val Ser Ala Phe Leu Leu Leu Val Ala Leu Ser 
1               5                   10                  15      


Tyr Thr Leu Ala Arg Asp Thr Thr Val Lys Pro Gly Ala Lys Lys Asp 
            20                  25                  30          


Thr Lys Asp Ser Arg Pro Lys Leu Pro Gln Thr Leu Ser Arg Gly Trp 
        35                  40                  45              


Gly Asp Gln Leu Ile Trp Thr Gln Thr Tyr Glu Glu Ala Leu Tyr Lys 
    50                  55                  60                  


Ser Lys Thr Ser Asn Lys Pro Leu Met Ile Ile His His Leu Asp Glu 
65                  70                  75                  80  


Cys Pro His Ser Gln Ala Leu Lys Lys Val Phe Ala Glu Asn Lys Glu 
                85                  90                  95      


Ile Gln Lys Leu Ala Glu Gln Phe Val Leu Leu Asn Leu Val Tyr Glu 
            100                 105                 110         


Thr Thr Asp Lys His Leu Ser Pro Asp Gly Gln Tyr Val Pro Arg Ile 
        115                 120                 125             


Met Phe Val Asp Pro Ser Leu Thr Val Arg Ala Asp Ile Thr Gly Arg 
    130                 135                 140                 


Tyr Ser Asn Arg Leu Tyr Ala Tyr Glu Pro Ala Asp Thr Ala Leu Cys 
145                 150                 155                 160 


Lys Cys Asp Leu Gln Phe Gly Cys Cys Pro Arg Val Glu His Leu Tyr 
                165                 170                 175     


Cys Cys Ser Asp Gly Thr Arg Gly Cys Met Val Arg 
            180                 185             


<210>  613
<211>  175
<212>  PRT
<213>  Homo Sapiens

<400>  613

Met Glu Lys Ile Pro Val Ser Ala Phe Leu Leu Leu Val Ala Leu Ser 
1               5                   10                  15      


Tyr Thr Leu Ala Arg Asp Thr Thr Val Lys Pro Gly Ala Lys Lys Asp 
            20                  25                  30          


Thr Lys Asp Ser Arg Pro Lys Leu Pro Gln Thr Leu Ser Arg Gly Trp 
        35                  40                  45              


Gly Asp Gln Leu Ile Trp Thr Gln Thr Tyr Glu Glu Ala Leu Tyr Lys 
    50                  55                  60                  


Ser Lys Thr Ser Asn Lys Pro Leu Met Ile Ile His His Leu Asp Glu 
65                  70                  75                  80  


Cys Pro His Ser Gln Ala Leu Lys Lys Val Phe Ala Glu Asn Lys Glu 
                85                  90                  95      


Ile Gln Lys Leu Ala Glu Gln Phe Val Leu Leu Asn Leu Val Tyr Glu 
            100                 105                 110         


Thr Thr Asp Lys His Leu Ser Pro Asp Gly Gln Tyr Val Pro Arg Ile 
        115                 120                 125             


Met Phe Val Asp Pro Ser Leu Thr Val Arg Ala Asp Ile Thr Gly Arg 
    130                 135                 140                 


Tyr Ser Asn Arg Leu Tyr Ala Tyr Glu Pro Ala Asp Thr Ala Leu Leu 
145                 150                 155                 160 


Leu Asp Asn Met Lys Lys Ala Leu Lys Leu Leu Lys Thr Glu Leu 
                165                 170                 175 


<210>  614
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  614

Pro Leu Met Ile Ile His His Leu Asp Glu Cys Pro His Ser Gln Ala 
1               5                   10                  15      


Leu Lys Lys Val Phe Ala Glu Asn Lys Glu Ile Gln Lys Leu Ala Glu 
            20                  25                  30          


Gln Phe Val Leu Leu Asn Leu Val Tyr Glu Thr Thr Asp Lys His Leu 
        35                  40                  45              


Ser Pro Asp Gly Gln Tyr Val Pro Arg Ile Met Phe Val Asp Pro Ser 
    50                  55                  60                  


Leu Thr Val Arg Ala Asp Ile Thr Gly Arg Tyr Ser Asn Arg Leu Tyr 
65                  70                  75                  80  


Ala Tyr Glu Pro Ala Asp Thr Ala Leu Cys Lys Cys Asp Leu Gln Phe 
                85                  90                  95      


Gly Cys Cys Pro Arg Val Glu His Leu Tyr Cys Cys Ser Asp Gly Thr 
            100                 105                 110         


Arg Gly Cys Met Val Ser Ala 
        115                 


<210>  615
<211>  163
<212>  PRT
<213>  Homo Sapiens

<400>  615

Met Met Leu His Ser Ala Leu Gly Leu Cys Leu Leu Leu Val Thr Val 
1               5                   10                  15      


Ser Ser Asn Leu Ala Ile Ala Ile Lys Lys Glu Lys Arg Pro Pro Gln 
            20                  25                  30          


Thr Leu Ser Arg Gly Trp Gly Asp Asp Ile Thr Trp Val Gln Thr Tyr 
        35                  40                  45              


Glu Glu Gly Leu Phe Tyr Ala Gln Lys Ser Lys Lys Pro Leu Met Val 
    50                  55                  60                  


Ile His His Leu Glu Asp Cys Gln Tyr Ser Gln Ala Leu Lys Lys Val 
65                  70                  75                  80  


Phe Ala Gln Asn Glu Glu Ile Gln Glu Met Ala Gln Asn Lys Phe Ile 
                85                  90                  95      


Met Leu Asn Leu Met His Glu Thr Thr Asp Lys Asn Leu Ser Pro Asp 
            100                 105                 110         


Gly Gln Tyr Val Pro Arg Ile Met Phe Val Asp Pro Ser Leu Thr Val 
        115                 120                 125             


Arg Ala Asp Ile Ala Gly Arg Tyr Ser Asn Arg Leu Tyr Thr Tyr Glu 
    130                 135                 140                 


Pro Arg Asp Leu Pro Leu Cys Lys Tyr Ser Gln Met Ile Ser Asn Ser 
145                 150                 155                 160 


Gly His Ser 
            


<210>  616
<211>  166
<212>  PRT
<213>  Homo Sapiens

<400>  616

Met Met Leu His Ser Ala Leu Gly Leu Cys Leu Leu Leu Val Thr Val 
1               5                   10                  15      


Ser Ser Asn Leu Ala Ile Ala Ile Lys Lys Glu Lys Arg Pro Pro Gln 
            20                  25                  30          


Thr Leu Ser Arg Gly Trp Gly Asp Asp Ile Thr Trp Val Gln Thr Tyr 
        35                  40                  45              


Glu Glu Gly Leu Phe Tyr Ala Gln Lys Ser Lys Lys Pro Leu Met Val 
    50                  55                  60                  


Ile His His Leu Glu Asp Cys Gln Tyr Ser Gln Ala Leu Lys Lys Val 
65                  70                  75                  80  


Phe Ala Gln Asn Glu Glu Ile Gln Glu Met Ala Gln Asn Lys Phe Ile 
                85                  90                  95      


Met Leu Asn Leu Met His Glu Thr Thr Asp Lys Asn Leu Ser Pro Asp 
            100                 105                 110         


Gly Gln Tyr Val Pro Arg Ile Met Phe Val Asp Pro Ser Leu Thr Val 
        115                 120                 125             


Arg Ala Asp Ile Ala Gly Arg Tyr Ser Asn Arg Leu Tyr Thr Tyr Glu 
    130                 135                 140                 


Pro Arg Asp Leu Pro Leu Leu Ile Glu Asn Met Lys Lys Ala Leu Arg 
145                 150                 155                 160 


Leu Ile Gln Ser Glu Leu 
                165     


<210>  617
<211>  129
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  617

Xaa Asn Ile Gln Asn Thr Phe Pro Thr Arg Ala Leu Ala Lys Ser Gly 
1               5                   10                  15      


Trp Gly Asp Asp Ile Thr Trp Val Gln Thr Tyr Glu Glu Gly Leu Phe 
            20                  25                  30          


Tyr Ala Gln Lys Ser Lys Lys Pro Leu Met Val Ile His His Leu Glu 
        35                  40                  45              


Asp Cys Gln Tyr Ser Gln Ala Leu Lys Lys Val Phe Ala Gln Asn Glu 
    50                  55                  60                  


Glu Ile Gln Glu Met Ala Gln Asn Lys Phe Ile Met Leu Asn Leu Met 
65                  70                  75                  80  


His Glu Thr Thr Asp Lys Asn Leu Ser Pro Asp Gly Gln Tyr Val Pro 
                85                  90                  95      


Arg Ile Met Phe Val Asp Pro Ser Leu Thr Val Arg Ala Asp Ile Ala 
            100                 105                 110         


Gly Arg Tyr Ser Asn Arg Leu Tyr Thr Tyr Glu Pro Arg Asp Leu Pro 
        115                 120                 125             


Leu 
    


<210>  618
<211>  2045
<212>  PRT
<213>  Homo Sapiens

<400>  618

Met Ala Gly Arg Ser His Pro Gly Pro Leu Arg Pro Leu Leu Pro Leu 
1               5                   10                  15      


Leu Val Val Ala Ala Cys Val Leu Pro Gly Ala Gly Gly Thr Cys Pro 
            20                  25                  30          


Glu Arg Ala Leu Glu Arg Arg Glu Glu Glu Ala Asn Val Val Leu Thr 
        35                  40                  45              


Gly Thr Val Glu Glu Ile Leu Asn Val Asp Pro Val Gln His Thr Tyr 
    50                  55                  60                  


Ser Cys Lys Val Arg Val Trp Arg Tyr Leu Lys Gly Lys Asp Leu Val 
65                  70                  75                  80  


Ala Arg Glu Ser Leu Leu Asp Gly Gly Asn Lys Val Val Ile Ser Gly 
                85                  90                  95      


Phe Gly Asp Pro Leu Ile Cys Asp Asn Gln Val Ser Thr Gly Asp Thr 
            100                 105                 110         


Arg Ile Phe Phe Val Asn Pro Ala Pro Pro Tyr Leu Trp Pro Ala His 
        115                 120                 125             


Lys Asn Glu Leu Met Leu Asn Ser Ser Leu Met Arg Ile Thr Leu Arg 
    130                 135                 140                 


Asn Leu Glu Glu Val Glu Phe Cys Val Glu Asp Lys Pro Gly Thr His 
145                 150                 155                 160 


Phe Thr Pro Val Pro Pro Thr Pro Pro Asp Ala Cys Arg Gly Met Leu 
                165                 170                 175     


Cys Gly Phe Gly Ala Val Cys Glu Pro Asn Ala Glu Gly Pro Gly Arg 
            180                 185                 190         


Ala Ser Cys Val Cys Lys Lys Ser Pro Cys Pro Ser Val Val Ala Pro 
        195                 200                 205             


Val Cys Gly Ser Asp Ala Ser Thr Tyr Ser Asn Glu Cys Glu Leu Gln 
    210                 215                 220                 


Arg Ala Gln Cys Ser Gln Gln Arg Arg Ile Arg Leu Leu Ser Arg Gly 
225                 230                 235                 240 


Pro Cys Gly Ser Arg Asp Pro Cys Ser Asn Val Thr Cys Ser Phe Gly 
                245                 250                 255     


Ser Thr Cys Ala Arg Ser Ala Asp Gly Leu Thr Ala Ser Cys Leu Cys 
            260                 265                 270         


Pro Ala Thr Cys Arg Gly Ala Pro Glu Gly Thr Val Cys Gly Ser Asp 
        275                 280                 285             


Gly Ala Asp Tyr Pro Gly Glu Cys Gln Leu Leu Arg Arg Ala Cys Ala 
    290                 295                 300                 


Arg Gln Glu Asn Val Phe Lys Lys Phe Asp Gly Pro Cys Asp Pro Cys 
305                 310                 315                 320 


Gln Gly Ala Leu Pro Asp Pro Ser Arg Ser Cys Arg Val Asn Pro Arg 
                325                 330                 335     


Thr Arg Arg Pro Glu Met Leu Leu Arg Pro Glu Ser Cys Pro Ala Arg 
            340                 345                 350         


Gln Ala Pro Val Cys Gly Asp Asp Gly Val Thr Tyr Glu Asn Asp Cys 
        355                 360                 365             


Val Met Gly Arg Ser Gly Ala Ala Arg Gly Leu Leu Leu Gln Lys Val 
    370                 375                 380                 


Arg Ser Gly Gln Cys Gln Gly Arg Asp Gln Cys Pro Glu Pro Cys Arg 
385                 390                 395                 400 


Phe Asn Ala Val Cys Leu Ser Arg Arg Gly Arg Pro Arg Cys Ser Cys 
                405                 410                 415     


Asp Arg Val Thr Cys Asp Gly Ala Tyr Arg Pro Val Cys Ala Gln Asp 
            420                 425                 430         


Gly Arg Thr Tyr Asp Ser Asp Cys Trp Arg Gln Gln Ala Glu Cys Arg 
        435                 440                 445             


Gln Gln Arg Ala Ile Pro Ser Lys His Gln Gly Pro Cys Asp Gln Ala 
    450                 455                 460                 


Pro Ser Pro Cys Leu Gly Val Gln Cys Ala Phe Gly Ala Thr Cys Ala 
465                 470                 475                 480 


Val Lys Asn Gly Gln Ala Ala Cys Glu Cys Leu Gln Ala Cys Ser Ser 
                485                 490                 495     


Leu Tyr Asp Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly Ser Ala 
            500                 505                 510         


Cys Glu Leu Glu Ala Thr Ala Cys Thr Leu Gly Arg Glu Ile Gln Val 
        515                 520                 525             


Ala Arg Lys Gly Pro Cys Asp Arg Cys Gly Gln Cys Arg Phe Gly Ala 
    530                 535                 540                 


Leu Cys Glu Ala Glu Thr Gly Arg Cys Val Cys Pro Ser Glu Cys Val 
545                 550                 555                 560 


Ala Leu Ala Gln Pro Val Cys Gly Ser Asp Gly His Thr Tyr Pro Ser 
                565                 570                 575     


Glu Cys Met Leu His Val His Ala Cys Thr His Gln Ile Ser Leu His 
            580                 585                 590         


Val Ala Ser Ala Gly Pro Cys Glu Thr Cys Gly Asp Ala Val Cys Ala 
        595                 600                 605             


Phe Gly Ala Val Cys Ser Ala Gly Gln Cys Val Cys Pro Arg Cys Glu 
    610                 615                 620                 


His Pro Pro Pro Gly Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly 
625                 630                 635                 640 


Ser Ala Cys Glu Leu Arg Glu Ala Ala Cys Leu Gln Gln Thr Gln Ile 
                645                 650                 655     


Glu Glu Ala Arg Ala Gly Pro Cys Glu Gln Ala Glu Cys Gly Ser Gly 
            660                 665                 670         


Gly Ser Gly Ser Gly Glu Asp Gly Asp Cys Glu Gln Glu Leu Cys Arg 
        675                 680                 685             


Gln Arg Gly Gly Ile Trp Asp Glu Asp Ser Glu Asp Gly Pro Cys Val 
    690                 695                 700                 


Cys Asp Phe Ser Cys Gln Ser Val Pro Gly Ser Pro Val Cys Gly Ser 
705                 710                 715                 720 


Asp Gly Val Thr Tyr Ser Thr Glu Cys Glu Leu Lys Lys Ala Arg Cys 
                725                 730                 735     


Glu Ser Gln Arg Gly Leu Tyr Val Ala Ala Gln Gly Ala Cys Arg Gly 
            740                 745                 750         


Pro Thr Phe Ala Pro Leu Pro Pro Val Ala Pro Leu His Cys Ala Gln 
        755                 760                 765             


Thr Pro Tyr Gly Cys Cys Gln Asp Asn Ile Thr Ala Ala Arg Gly Val 
    770                 775                 780                 


Gly Leu Ala Gly Cys Pro Ser Ala Cys Gln Cys Asn Pro His Gly Ser 
785                 790                 795                 800 


Tyr Gly Gly Thr Cys Asp Pro Ala Thr Gly Gln Cys Ser Cys Arg Pro 
                805                 810                 815     


Gly Val Gly Gly Leu Arg Cys Asp Arg Cys Glu Pro Gly Phe Trp Asn 
            820                 825                 830         


Phe Arg Gly Ile Val Thr Asp Gly Arg Ser Gly Cys Thr Pro Cys Ser 
        835                 840                 845             


Cys Asp Pro Gln Gly Ala Val Arg Asp Asp Cys Glu Gln Met Thr Gly 
    850                 855                 860                 


Leu Cys Ser Cys Lys Pro Gly Val Ala Gly Pro Lys Cys Gly Gln Cys 
865                 870                 875                 880 


Pro Asp Gly Arg Ala Leu Gly Pro Ala Gly Cys Glu Ala Asp Ala Ser 
                885                 890                 895     


Ala Pro Ala Thr Cys Ala Glu Met Arg Cys Glu Phe Gly Ala Arg Cys 
            900                 905                 910         


Val Glu Glu Ser Gly Ser Ala His Cys Val Cys Pro Met Leu Thr Cys 
        915                 920                 925             


Pro Glu Ala Asn Ala Thr Lys Val Cys Gly Ser Asp Gly Val Thr Tyr 
    930                 935                 940                 


Gly Asn Glu Cys Gln Leu Lys Thr Ile Ala Cys Arg Gln Gly Leu Gln 
945                 950                 955                 960 


Ile Ser Ile Gln Ser Leu Gly Pro Cys Gln Glu Ala Val Ala Pro Ser 
                965                 970                 975     


Thr His Pro Thr Ser Ala Ser Val Thr Val Thr Thr Pro Gly Leu Leu 
            980                 985                 990         


Leu Ser Gln Ala Leu Pro Ala Pro  Pro Gly Ala Leu Pro  Leu Ala Pro 
        995                 1000                 1005             


Ser Ser  Thr Ala His Ser Gln  Thr Thr Pro Pro Pro  Ser Ser Arg 
    1010                 1015                 1020             


Pro Arg  Thr Thr Ala Ser Val  Pro Arg Thr Thr Val  Trp Pro Val 
    1025                 1030                 1035             


Leu Thr  Val Pro Pro Thr Ala  Pro Ser Pro Ala Pro  Ser Leu Val 
    1040                 1045                 1050             


Ala Ser  Ala Phe Gly Glu Ser  Gly Ser Thr Asp Gly  Ser Ser Asp 
    1055                 1060                 1065             


Glu Glu  Leu Ser Gly Asp Gln  Glu Ala Ser Gly Gly  Gly Ser Gly 
    1070                 1075                 1080             


Gly Leu  Glu Pro Leu Glu Gly  Ser Ser Val Ala Thr  Pro Gly Pro 
    1085                 1090                 1095             


Pro Val  Glu Arg Ala Ser Cys  Tyr Asn Ser Ala Leu  Gly Cys Cys 
    1100                 1105                 1110             


Ser Asp  Gly Lys Thr Pro Ser  Leu Asp Ala Glu Gly  Ser Asn Cys 
    1115                 1120                 1125             


Pro Ala  Thr Lys Val Phe Gln  Gly Val Leu Glu Leu  Glu Gly Val 
    1130                 1135                 1140             


Glu Gly  Gln Glu Leu Phe Tyr  Thr Pro Glu Met Ala  Asp Pro Lys 
    1145                 1150                 1155             


Ser Glu  Leu Phe Gly Glu Thr  Ala Arg Ser Ile Glu  Ser Thr Leu 
    1160                 1165                 1170             


Asp Asp  Leu Phe Arg Asn Ser  Asp Val Lys Lys Asp  Phe Arg Ser 
    1175                 1180                 1185             


Val Arg  Leu Arg Asp Leu Gly  Pro Gly Lys Ser Val  Arg Ala Ile 
    1190                 1195                 1200             


Val Asp  Val His Phe Asp Pro  Thr Thr Ala Phe Arg  Ala Pro Asp 
    1205                 1210                 1215             


Val Ala  Arg Ala Leu Leu Arg  Gln Ile Gln Val Ser  Arg Arg Arg 
    1220                 1225                 1230             


Ser Leu  Gly Val Arg Arg Pro  Leu Gln Glu His Val  Arg Phe Met 
    1235                 1240                 1245             


Asp Phe  Asp Trp Phe Pro Ala  Phe Ile Thr Gly Ala  Thr Ser Gly 
    1250                 1255                 1260             


Ala Ile  Ala Ala Gly Ala Thr  Ala Arg Ala Thr Thr  Ala Ser Arg 
    1265                 1270                 1275             


Leu Pro  Ser Ser Ala Val Thr  Pro Arg Ala Pro His  Pro Ser His 
    1280                 1285                 1290             


Thr Ser  Gln Pro Val Ala Lys  Thr Thr Ala Ala Pro  Thr Thr Arg 
    1295                 1300                 1305             


Arg Pro  Pro Thr Thr Ala Pro  Ser Arg Val Pro Gly  Arg Arg Pro 
    1310                 1315                 1320             


Pro Ala  Pro Gln Gln Pro Pro  Lys Pro Cys Asp Ser  Gln Pro Cys 
    1325                 1330                 1335             


Phe His  Gly Gly Thr Cys Gln  Asp Trp Ala Leu Gly  Gly Gly Phe 
    1340                 1345                 1350             


Thr Cys  Ser Cys Pro Ala Gly  Arg Gly Gly Ala Val  Cys Glu Lys 
    1355                 1360                 1365             


Val Leu  Gly Ala Pro Val Pro  Ala Phe Glu Gly Arg  Ser Phe Leu 
    1370                 1375                 1380             


Ala Phe  Pro Thr Leu Arg Ala  Tyr His Thr Leu Arg  Leu Ala Leu 
    1385                 1390                 1395             


Glu Phe  Arg Ala Leu Glu Pro  Gln Gly Leu Leu Leu  Tyr Asn Gly 
    1400                 1405                 1410             


Asn Ala  Arg Gly Lys Asp Phe  Leu Ala Leu Ala Leu  Leu Asp Gly 
    1415                 1420                 1425             


Arg Val  Gln Leu Arg Phe Asp  Thr Gly Ser Gly Pro  Ala Val Leu 
    1430                 1435                 1440             


Thr Ser  Ala Val Pro Val Glu  Pro Gly Gln Trp His  Arg Leu Glu 
    1445                 1450                 1455             


Leu Ser  Arg His Trp Arg Arg  Gly Thr Leu Ser Val  Asp Gly Glu 
    1460                 1465                 1470             


Thr Pro  Val Leu Gly Glu Ser  Pro Ser Gly Thr Asp  Gly Leu Asn 
    1475                 1480                 1485             


Leu Asp  Thr Asp Leu Phe Val  Gly Gly Val Pro Glu  Asp Gln Ala 
    1490                 1495                 1500             


Ala Val  Ala Leu Glu Arg Thr  Phe Val Gly Ala Gly  Leu Arg Gly 
    1505                 1510                 1515             


Cys Ile  Arg Leu Leu Asp Val  Asn Asn Gln Arg Leu  Glu Leu Gly 
    1520                 1525                 1530             


Ile Gly  Pro Gly Ala Ala Thr  Arg Gly Ser Gly Val  Gly Glu Cys 
    1535                 1540                 1545             


Gly Asp  His Pro Cys Leu Pro  Asn Pro Cys His Gly  Gly Ala Pro 
    1550                 1555                 1560             


Cys Gln  Asn Leu Glu Ala Gly  Arg Phe His Cys Gln  Cys Pro Pro 
    1565                 1570                 1575             


Gly Arg  Val Gly Pro Thr Cys  Ala Asp Glu Lys Ser  Pro Cys Gln 
    1580                 1585                 1590             


Pro Asn  Pro Cys His Gly Ala  Ala Pro Cys Arg Val  Leu Pro Glu 
    1595                 1600                 1605             


Gly Gly  Ala Gln Cys Glu Cys  Pro Leu Gly Arg Glu  Gly Thr Phe 
    1610                 1615                 1620             


Cys Gln  Thr Ala Ser Gly Gln  Asp Gly Ser Gly Pro  Phe Leu Ala 
    1625                 1630                 1635             


Asp Phe  Asn Gly Phe Ser His  Leu Glu Leu Arg Gly  Leu His Thr 
    1640                 1645                 1650             


Phe Ala  Arg Asp Leu Gly Glu  Lys Met Ala Leu Glu  Val Val Phe 
    1655                 1660                 1665             


Leu Ala  Arg Gly Pro Ser Gly  Leu Leu Leu Tyr Asn  Gly Gln Lys 
    1670                 1675                 1680             


Thr Asp  Gly Lys Gly Asp Phe  Val Ser Leu Ala Leu  Arg Asp Arg 
    1685                 1690                 1695             


Arg Leu  Glu Phe Arg Tyr Asp  Leu Gly Lys Gly Ala  Ala Val Ile 
    1700                 1705                 1710             


Arg Ser  Arg Glu Pro Val Thr  Leu Gly Ala Trp Thr  Arg Val Ser 
    1715                 1720                 1725             


Leu Glu  Arg Asn Gly Arg Lys  Gly Ala Leu Arg Val  Gly Asp Gly 
    1730                 1735                 1740             


Pro Arg  Val Leu Gly Glu Ser  Pro Val Pro His Thr  Val Leu Asn 
    1745                 1750                 1755             


Leu Lys  Glu Pro Leu Tyr Val  Gly Gly Ala Pro Asp  Phe Ser Lys 
    1760                 1765                 1770             


Leu Ala  Arg Ala Ala Ala Val  Ser Ser Gly Phe Asp  Gly Ala Ile 
    1775                 1780                 1785             


Gln Leu  Val Ser Leu Gly Gly  Arg Gln Leu Leu Thr  Pro Glu His 
    1790                 1795                 1800             


Val Leu  Arg Gln Val Asp Val  Thr Ser Phe Ala Gly  His Pro Cys 
    1805                 1810                 1815             


Thr Arg  Ala Ser Gly His Pro  Cys Leu Asn Gly Ala  Ser Cys Val 
    1820                 1825                 1830             


Pro Arg  Glu Ala Ala Tyr Val  Cys Leu Cys Pro Gly  Gly Phe Ser 
    1835                 1840                 1845             


Gly Pro  His Cys Glu Lys Gly  Leu Val Glu Lys Ser  Ala Gly Asp 
    1850                 1855                 1860             


Val Asp  Thr Leu Ala Phe Asp  Gly Arg Thr Phe Val  Glu Tyr Leu 
    1865                 1870                 1875             


Asn Ala  Val Thr Glu Ser Glu  Lys Ala Leu Gln Ser  Asn His Phe 
    1880                 1885                 1890             


Glu Leu  Ser Leu Arg Thr Glu  Ala Thr Gln Gly Leu  Val Leu Trp 
    1895                 1900                 1905             


Ser Gly  Lys Ala Thr Glu Arg  Ala Asp Tyr Val Ala  Leu Ala Ile 
    1910                 1915                 1920             


Val Asp  Gly His Leu Gln Leu  Ser Tyr Asn Leu Gly  Ser Gln Pro 
    1925                 1930                 1935             


Val Val  Leu Arg Ser Thr Val  Pro Val Asn Thr Asn  Arg Trp Leu 
    1940                 1945                 1950             


Arg Val  Val Ala His Arg Glu  Gln Arg Glu Gly Ser  Leu Gln Val 
    1955                 1960                 1965             


Gly Asn  Glu Ala Pro Val Thr  Gly Ser Ser Pro Leu  Gly Ala Thr 
    1970                 1975                 1980             


Gln Leu  Asp Thr Asp Gly Ala  Leu Trp Leu Gly Gly  Leu Pro Glu 
    1985                 1990                 1995             


Leu Pro  Val Gly Pro Ala Leu  Pro Lys Ala Tyr Gly  Thr Gly Phe 
    2000                 2005                 2010             


Val Gly  Cys Leu Arg Asp Val  Val Val Gly Arg His  Pro Leu His 
    2015                 2020                 2025             


Leu Leu  Glu Asp Ala Val Thr  Lys Pro Glu Leu Arg  Pro Cys Pro 
    2030                 2035                 2040             


Thr Pro  
    2045 


<210>  619
<211>  86
<212>  PRT
<213>  Homo Sapiens

<400>  619

Met Pro Pro Leu Pro Leu Ala Arg Asp Thr Arg Gln Pro Pro Gly Ala 
1               5                   10                  15      


Ser Leu Leu Val Arg Gly Phe Met Val Pro Cys Asn Ala Cys Leu Ile 
            20                  25                  30          


Leu Leu Ala Thr Ala Thr Leu Gly Phe Ala Val Leu Leu Phe Leu Asn 
        35                  40                  45              


Asn Tyr Lys Pro Gly Thr His Phe Thr Pro Val Pro Pro Thr Pro Pro 
    50                  55                  60                  


Asp Ala Cys Arg Gly Met Leu Cys Gly Phe Gly Ala Val Cys Glu Pro 
65                  70                  75                  80  


Asn Ala Glu Gly Pro Gly 
                85      


<210>  620
<211>  1930
<212>  PRT
<213>  Homo Sapiens

<400>  620

Met Arg Ile Thr Leu Arg Asn Leu Glu Glu Val Glu Phe Cys Val Glu 
1               5                   10                  15      


Asp Lys Pro Gly Thr His Phe Thr Pro Val Pro Pro Thr Pro Pro Asp 
            20                  25                  30          


Ala Cys Arg Gly Met Leu Cys Gly Phe Gly Ala Val Cys Glu Pro Asn 
        35                  40                  45              


Ala Glu Gly Pro Gly Arg Ala Ser Cys Val Cys Lys Lys Ser Pro Cys 
    50                  55                  60                  


Pro Ser Val Val Ala Pro Val Cys Gly Ser Asp Ala Ser Thr Tyr Ser 
65                  70                  75                  80  


Asn Glu Cys Glu Leu Gln Arg Ala Gln Cys Ser Gln Gln Arg Arg Ile 
                85                  90                  95      


Arg Leu Leu Ser Arg Gly Pro Cys Gly Ser Arg Asp Pro Cys Ser Asn 
            100                 105                 110         


Val Thr Cys Ser Phe Gly Ser Thr Cys Ala Arg Ser Ala Asp Gly Leu 
        115                 120                 125             


Thr Ala Ser Cys Leu Cys Pro Ala Thr Cys Arg Gly Ala Pro Glu Gly 
    130                 135                 140                 


Thr Val Cys Gly Ser Asp Gly Ala Asp Tyr Pro Gly Glu Cys Gln Leu 
145                 150                 155                 160 


Leu Arg Arg Ala Cys Ala Arg Gln Glu Asn Val Phe Lys Lys Phe Asp 
                165                 170                 175     


Gly Pro Cys Asp Pro Cys Gln Gly Ala Leu Pro Asp Pro Ser Arg Ser 
            180                 185                 190         


Cys Arg Val Asn Pro Arg Thr Arg Arg Pro Glu Met Leu Leu Arg Pro 
        195                 200                 205             


Glu Ser Cys Pro Ala Arg Gln Ala Pro Val Cys Gly Asp Asp Gly Val 
    210                 215                 220                 


Thr Tyr Glu Asn Asp Cys Val Met Gly Arg Ser Gly Ala Ala Arg Gly 
225                 230                 235                 240 


Leu Leu Leu Gln Lys Val Arg Ser Gly Gln Cys Gln Gly Arg Asp Gln 
                245                 250                 255     


Cys Pro Glu Pro Cys Arg Phe Asn Ala Val Cys Leu Ser Arg Arg Gly 
            260                 265                 270         


Arg Pro Arg Cys Ser Cys Asp Arg Val Thr Cys Asp Gly Ala Tyr Arg 
        275                 280                 285             


Pro Val Cys Ala Gln Asp Gly Arg Thr Tyr Asp Ser Asp Cys Trp Arg 
    290                 295                 300                 


Gln Gln Ala Glu Cys Arg Gln Gln Arg Ala Ile Pro Ser Lys His Gln 
305                 310                 315                 320 


Gly Pro Cys Asp Gln Ala Pro Ser Pro Cys Leu Gly Val Gln Cys Ala 
                325                 330                 335     


Phe Gly Ala Thr Cys Ala Val Lys Asn Gly Gln Ala Ala Cys Glu Cys 
            340                 345                 350         


Leu Gln Ala Cys Ser Ser Leu Tyr Asp Pro Val Cys Gly Ser Asp Gly 
        355                 360                 365             


Val Thr Tyr Gly Ser Ala Cys Glu Leu Glu Ala Thr Ala Cys Thr Leu 
    370                 375                 380                 


Gly Arg Glu Ile Gln Val Ala Arg Lys Gly Pro Cys Asp Arg Cys Gly 
385                 390                 395                 400 


Gln Cys Arg Phe Gly Ala Leu Cys Glu Ala Glu Thr Gly Arg Cys Val 
                405                 410                 415     


Cys Pro Ser Glu Cys Val Ala Leu Ala Gln Pro Val Cys Gly Ser Asp 
            420                 425                 430         


Gly His Thr Tyr Pro Ser Glu Cys Met Leu His Val His Ala Cys Thr 
        435                 440                 445             


His Gln Ile Ser Leu His Val Ala Ser Ala Gly Pro Cys Glu Thr Cys 
    450                 455                 460                 


Gly Asp Ala Val Cys Ala Phe Gly Ala Val Cys Ser Ala Gly Gln Cys 
465                 470                 475                 480 


Val Cys Pro Arg Cys Glu His Pro Pro Pro Gly Pro Val Cys Gly Ser 
                485                 490                 495     


Asp Gly Val Thr Tyr Gly Ser Ala Cys Glu Leu Arg Glu Ala Ala Cys 
            500                 505                 510         


Leu Gln Gln Thr Gln Ile Glu Glu Ala Arg Ala Gly Pro Cys Glu Gln 
        515                 520                 525             


Ala Glu Cys Gly Ser Gly Gly Ser Gly Ser Gly Glu Asp Gly Asp Cys 
    530                 535                 540                 


Glu Gln Glu Leu Cys Arg Gln Arg Gly Gly Ile Trp Asp Glu Asp Ser 
545                 550                 555                 560 


Glu Asp Gly Pro Cys Val Cys Asp Phe Ser Cys Gln Ser Val Pro Gly 
                565                 570                 575     


Ser Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Ser Thr Glu Cys Glu 
            580                 585                 590         


Leu Lys Lys Ala Arg Cys Glu Ser Gln Arg Gly Leu Tyr Val Ala Ala 
        595                 600                 605             


Gln Gly Ala Cys Arg Gly Pro Thr Phe Ala Pro Leu Pro Pro Val Ala 
    610                 615                 620                 


Pro Leu His Cys Ala Gln Thr Pro Tyr Gly Cys Cys Gln Asp Asn Ile 
625                 630                 635                 640 


Thr Ala Ala Arg Gly Val Gly Leu Ala Gly Cys Pro Ser Ala Cys Gln 
                645                 650                 655     


Cys Asn Pro His Gly Ser Tyr Gly Gly Thr Cys Asp Pro Ala Thr Gly 
            660                 665                 670         


Gln Cys Ser Cys Arg Pro Gly Val Gly Gly Leu Arg Cys Asp Arg Cys 
        675                 680                 685             


Glu Pro Gly Phe Trp Asn Phe Arg Gly Ile Val Thr Asp Gly Arg Ser 
    690                 695                 700                 


Gly Cys Thr Pro Cys Ser Cys Asp Pro Gln Gly Ala Val Arg Asp Asp 
705                 710                 715                 720 


Cys Glu Gln Met Thr Gly Leu Cys Ser Cys Lys Pro Gly Val Ala Gly 
                725                 730                 735     


Pro Lys Cys Gly Gln Cys Pro Asp Gly Arg Ala Leu Gly Pro Ala Gly 
            740                 745                 750         


Cys Glu Ala Asp Ala Ser Ala Pro Ala Thr Cys Ala Glu Met Arg Cys 
        755                 760                 765             


Glu Phe Gly Ala Arg Cys Val Glu Glu Ser Gly Ser Ala His Cys Val 
    770                 775                 780                 


Cys Pro Met Leu Thr Cys Pro Glu Ala Asn Ala Thr Lys Val Cys Gly 
785                 790                 795                 800 


Ser Asp Gly Val Thr Tyr Gly Asn Glu Cys Gln Leu Lys Thr Ile Ala 
                805                 810                 815     


Cys Arg Gln Gly Leu Gln Ile Ser Ile Gln Ser Leu Gly Pro Cys Gln 
            820                 825                 830         


Glu Ala Val Ala Pro Ser Thr His Pro Thr Ser Ala Ser Val Thr Val 
        835                 840                 845             


Thr Thr Pro Gly Leu Leu Leu Ser Gln Ala Leu Pro Ala Pro Pro Gly 
    850                 855                 860                 


Ala Leu Pro Leu Ala Pro Ser Ser Thr Ala His Ser Gln Thr Thr Pro 
865                 870                 875                 880 


Pro Pro Ser Ser Arg Pro Arg Thr Thr Ala Ser Val Pro Arg Thr Thr 
                885                 890                 895     


Val Trp Pro Val Leu Thr Val Pro Pro Thr Ala Pro Ser Pro Ala Pro 
            900                 905                 910         


Ser Leu Val Ala Ser Ala Phe Gly Glu Ser Gly Ser Thr Asp Gly Ser 
        915                 920                 925             


Ser Asp Glu Glu Leu Ser Gly Asp Gln Glu Ala Ser Gly Gly Gly Ser 
    930                 935                 940                 


Gly Gly Leu Glu Pro Leu Glu Gly Ser Ser Val Ala Thr Pro Gly Pro 
945                 950                 955                 960 


Pro Val Glu Arg Ala Ser Cys Tyr Asn Ser Ala Leu Gly Cys Cys Ser 
                965                 970                 975     


Asp Gly Lys Thr Pro Ser Leu Asp Ala Glu Gly Ser Asn Cys Pro Ala 
            980                 985                 990         


Thr Lys Val Phe Gln Gly Val Leu  Glu Leu Glu Gly Val  Glu Gly Gln 
        995                 1000                 1005             


Glu Leu  Phe Tyr Thr Pro Glu  Met Ala Asp Pro Lys  Ser Glu Leu 
    1010                 1015                 1020             


Phe Gly  Glu Thr Ala Arg Ser  Ile Glu Ser Thr Leu  Asp Asp Leu 
    1025                 1030                 1035             


Phe Arg  Asn Ser Asp Val Lys  Lys Asp Phe Arg Ser  Val Arg Leu 
    1040                 1045                 1050             


Arg Asp  Leu Gly Pro Gly Lys  Ser Val Arg Ala Ile  Val Asp Val 
    1055                 1060                 1065             


His Phe  Asp Pro Thr Thr Ala  Phe Arg Ala Pro Asp  Val Ala Arg 
    1070                 1075                 1080             


Ala Leu  Leu Arg Gln Ile Gln  Val Ser Arg Arg Arg  Ser Leu Gly 
    1085                 1090                 1095             


Val Arg  Arg Pro Leu Gln Glu  His Val Arg Phe Met  Asp Phe Asp 
    1100                 1105                 1110             


Trp Phe  Pro Ala Phe Ile Thr  Gly Ala Thr Ser Gly  Ala Ile Ala 
    1115                 1120                 1125             


Ala Gly  Ala Thr Ala Arg Ala  Thr Thr Ala Ser Arg  Leu Pro Ser 
    1130                 1135                 1140             


Ser Ala  Val Thr Pro Arg Ala  Pro His Pro Ser His  Thr Ser Gln 
    1145                 1150                 1155             


Pro Val  Ala Lys Thr Thr Ala  Ala Pro Thr Thr Arg  Arg Pro Pro 
    1160                 1165                 1170             


Thr Thr  Ala Pro Ser Arg Val  Pro Gly Arg Arg Pro  Pro Ala Pro 
    1175                 1180                 1185             


Gln Gln  Pro Pro Lys Pro Cys  Asp Ser Gln Pro Cys  Phe His Gly 
    1190                 1195                 1200             


Gly Thr  Cys Gln Asp Trp Ala  Leu Gly Gly Gly Phe  Thr Cys Ser 
    1205                 1210                 1215             


Cys Pro  Ala Gly Arg Gly Gly  Ala Val Cys Glu Lys  Val Leu Gly 
    1220                 1225                 1230             


Ala Pro  Val Pro Ala Phe Glu  Gly Arg Ser Phe Leu  Ala Phe Pro 
    1235                 1240                 1245             


Thr Leu  Arg Ala Tyr His Thr  Leu Arg Leu Ala Leu  Glu Phe Arg 
    1250                 1255                 1260             


Ala Leu  Glu Pro Gln Gly Leu  Leu Leu Tyr Asn Gly  Asn Ala Arg 
    1265                 1270                 1275             


Gly Lys  Asp Phe Leu Ala Leu  Ala Leu Leu Asp Gly  Arg Val Gln 
    1280                 1285                 1290             


Leu Arg  Phe Asp Thr Gly Ser  Gly Pro Ala Val Leu  Thr Ser Ala 
    1295                 1300                 1305             


Val Pro  Val Glu Pro Gly Gln  Trp His Arg Leu Glu  Leu Ser Arg 
    1310                 1315                 1320             


His Trp  Arg Arg Gly Thr Leu  Ser Val Asp Gly Glu  Thr Pro Val 
    1325                 1330                 1335             


Leu Gly  Glu Ser Pro Ser Gly  Thr Asp Gly Leu Asn  Leu Asp Thr 
    1340                 1345                 1350             


Asp Leu  Phe Val Gly Gly Val  Pro Glu Asp Gln Ala  Ala Val Ala 
    1355                 1360                 1365             


Leu Glu  Arg Thr Phe Val Gly  Ala Gly Leu Arg Gly  Cys Ile Arg 
    1370                 1375                 1380             


Leu Leu  Asp Val Asn Asn Gln  Arg Leu Glu Leu Gly  Ile Gly Pro 
    1385                 1390                 1395             


Gly Ala  Ala Thr Arg Gly Ser  Gly Val Gly Glu Cys  Gly Asp His 
    1400                 1405                 1410             


Pro Cys  Leu Pro Asn Pro Cys  His Gly Gly Ala Pro  Cys Gln Asn 
    1415                 1420                 1425             


Leu Glu  Ala Gly Arg Phe His  Cys Gln Cys Pro Pro  Gly Arg Val 
    1430                 1435                 1440             


Gly Pro  Thr Cys Ala Asp Glu  Lys Ser Pro Cys Gln  Pro Asn Pro 
    1445                 1450                 1455             


Cys His  Gly Ala Ala Pro Cys  Arg Val Leu Pro Glu  Gly Gly Ala 
    1460                 1465                 1470             


Gln Cys  Glu Cys Pro Leu Gly  Arg Glu Gly Thr Phe  Cys Gln Thr 
    1475                 1480                 1485             


Ala Ser  Gly Gln Asp Gly Ser  Gly Pro Phe Leu Ala  Asp Phe Asn 
    1490                 1495                 1500             


Gly Phe  Ser His Leu Glu Leu  Arg Gly Leu His Thr  Phe Ala Arg 
    1505                 1510                 1515             


Asp Leu  Gly Glu Lys Met Ala  Leu Glu Val Val Phe  Leu Ala Arg 
    1520                 1525                 1530             


Gly Pro  Ser Gly Leu Leu Leu  Tyr Asn Gly Gln Lys  Thr Asp Gly 
    1535                 1540                 1545             


Lys Gly  Asp Phe Val Ser Leu  Ala Leu Arg Asp Arg  Arg Leu Glu 
    1550                 1555                 1560             


Phe Arg  Tyr Asp Leu Gly Lys  Gly Ala Ala Val Ile  Arg Ser Arg 
    1565                 1570                 1575             


Glu Pro  Val Thr Leu Gly Ala  Trp Thr Arg Val Ser  Leu Glu Arg 
    1580                 1585                 1590             


Asn Gly  Arg Lys Gly Ala Leu  Arg Val Gly Asp Gly  Pro Arg Val 
    1595                 1600                 1605             


Leu Gly  Glu Ser Pro Lys Ser  Arg Lys Val Pro His  Thr Val Leu 
    1610                 1615                 1620             


Asn Leu  Lys Glu Pro Leu Tyr  Val Gly Gly Ala Pro  Asp Phe Ser 
    1625                 1630                 1635             


Lys Leu  Ala Arg Ala Ala Ala  Val Ser Ser Gly Phe  Asp Gly Ala 
    1640                 1645                 1650             


Ile Gln  Leu Val Ser Leu Gly  Gly Arg Gln Leu Leu  Thr Pro Glu 
    1655                 1660                 1665             


His Val  Leu Arg Gln Val Asp  Val Thr Ser Phe Ala  Gly His Pro 
    1670                 1675                 1680             


Cys Thr  Arg Ala Ser Gly His  Pro Cys Leu Asn Gly  Ala Ser Cys 
    1685                 1690                 1695             


Val Pro  Arg Glu Ala Ala Tyr  Val Cys Leu Cys Pro  Gly Gly Phe 
    1700                 1705                 1710             


Ser Gly  Pro His Cys Glu Lys  Gly Leu Val Glu Lys  Ser Ala Gly 
    1715                 1720                 1725             


Asp Val  Asp Thr Leu Ala Phe  Asp Gly Arg Thr Phe  Val Glu Tyr 
    1730                 1735                 1740             


Leu Asn  Ala Val Thr Glu Ser  Glu Leu Ala Asn Glu  Ile Pro Val 
    1745                 1750                 1755             


Pro Glu  Thr Leu Asp Ser Gly  Ala Leu His Ser Glu  Lys Ala Leu 
    1760                 1765                 1770             


Gln Ser  Asn His Phe Glu Leu  Ser Leu Arg Thr Glu  Ala Thr Gln 
    1775                 1780                 1785             


Gly Leu  Val Leu Trp Ser Gly  Lys Ala Thr Glu Arg  Ala Asp Tyr 
    1790                 1795                 1800             


Val Ala  Leu Ala Ile Val Asp  Gly His Leu Gln Leu  Ser Tyr Asn 
    1805                 1810                 1815             


Leu Gly  Ser Gln Pro Val Val  Leu Arg Ser Thr Val  Pro Val Asn 
    1820                 1825                 1830             


Thr Asn  Arg Trp Leu Arg Val  Val Ala His Arg Glu  Gln Arg Glu 
    1835                 1840                 1845             


Gly Ser  Leu Gln Val Gly Asn  Glu Ala Pro Val Thr  Gly Ser Ser 
    1850                 1855                 1860             


Pro Leu  Gly Ala Thr Gln Leu  Asp Thr Asp Gly Ala  Leu Trp Leu 
    1865                 1870                 1875             


Gly Gly  Leu Pro Glu Leu Pro  Val Gly Pro Ala Leu  Pro Lys Ala 
    1880                 1885                 1890             


Tyr Gly  Thr Gly Phe Val Gly  Cys Leu Arg Asp Val  Val Val Gly 
    1895                 1900                 1905             


Arg His  Pro Leu His Leu Leu  Glu Asp Ala Val Thr  Lys Pro Glu 
    1910                 1915                 1920             


Leu Arg  Pro Cys Pro Thr Pro  
    1925                 1930 


<210>  621
<211>  287
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  621

Xaa Lys Gly Asp Phe Val Ser Leu Ala Leu Arg Asp Arg Arg Leu Glu 
1               5                   10                  15      


Phe Arg Tyr Asp Leu Gly Lys Gly Ala Ala Val Ile Arg Ser Arg Glu 
            20                  25                  30          


Pro Val Thr Leu Gly Ala Trp Thr Arg Val Ser Leu Glu Arg Asn Gly 
        35                  40                  45              


Arg Lys Gly Ala Leu Arg Val Gly Asp Gly Pro Arg Val Leu Gly Glu 
    50                  55                  60                  


Ser Pro Lys Ser Arg Lys Val Pro His Thr Val Leu Asn Leu Lys Glu 
65                  70                  75                  80  


Pro Leu Tyr Val Gly Gly Ala Pro Asp Phe Ser Lys Leu Ala Arg Ala 
                85                  90                  95      


Ala Ala Val Ser Ser Gly Phe Asp Gly Ala Ile Gln Leu Val Ser Leu 
            100                 105                 110         


Gly Gly Arg Gln Leu Leu Thr Pro Glu His Val Leu Arg Gln Val Asp 
        115                 120                 125             


Val Thr Ser Phe Ala Gly His Pro Cys Thr Arg Ala Ser Gly His Pro 
    130                 135                 140                 


Cys Leu Asn Gly Ala Ser Cys Val Pro Arg Glu Ala Ala Tyr Val Cys 
145                 150                 155                 160 


Leu Cys Pro Gly Gly Phe Ser Gly Pro His Cys Glu Lys Gly Leu Val 
                165                 170                 175     


Glu Lys Ser Ala Gly Asp Val Asp Thr Leu Ala Phe Asp Gly Arg Thr 
            180                 185                 190         


Phe Val Glu Tyr Leu Asn Ala Val Thr Glu Ser Glu Leu Ala Asn Glu 
        195                 200                 205             


Ile Pro Val Pro Glu Thr Leu Asp Ser Gly Ala Leu His Ser Glu Lys 
    210                 215                 220                 


Ala Leu Gln Ser Asn His Phe Glu Leu Ser Leu Arg Thr Glu Ala Thr 
225                 230                 235                 240 


Gln Gly Leu Val Leu Trp Ser Gly Lys Ala Thr Glu Arg Ala Asp Tyr 
                245                 250                 255     


Val Ala Leu Ala Ile Val Asp Gly His Leu Gln Leu Ser Tyr Asn Leu 
            260                 265                 270         


Gly Ser Gln Pro Val Val Leu Arg Ser Thr Val Pro Val Asn Thr 
        275                 280                 285         


<210>  622
<211>  132
<212>  PRT
<213>  Homo Sapiens

<400>  622

Met Leu Thr Ala Ala Val Leu Ser Cys Ala Leu Leu Leu Ala Leu Pro 
1               5                   10                  15      


Ala Thr Arg Gly Ala Gln Met Gly Leu Ala Pro Met Glu Gly Ile Arg 
            20                  25                  30          


Arg Pro Asp Gln Ala Leu Leu Pro Glu Leu Pro Gly Leu Gly Leu Arg 
        35                  40                  45              


Ala Pro Leu Lys Lys Thr Thr Ala Glu Gln Ala Glu Glu Asp Leu Leu 
    50                  55                  60                  


Gln Glu Ala Gln Ala Leu Ala Glu Val Leu Asp Leu Gln Asp Arg Glu 
65                  70                  75                  80  


Pro Arg Ser Ser Arg Arg Cys Val Arg Leu His Glu Ser Cys Leu Gly 
                85                  90                  95      


Gln Gln Val Pro Cys Cys Asp Pro Cys Ala Thr Cys Tyr Cys Arg Phe 
            100                 105                 110         


Phe Asn Ala Phe Cys Tyr Cys Arg Lys Leu Gly Thr Ala Met Asn Pro 
        115                 120                 125             


Cys Ser Arg Thr 
    130         


<210>  623
<211>  485
<212>  PRT
<213>  Homo Sapiens

<400>  623

Met Arg Lys Arg Ala Pro Gln Ser Glu Met Ala Pro Ala Gly Val Ser 
1               5                   10                  15      


Leu Arg Ala Thr Ile Leu Cys Leu Leu Ala Trp Ala Gly Leu Ala Ala 
            20                  25                  30          


Gly Asp Arg Val Tyr Ile His Pro Phe His Leu Val Ile His Asn Glu 
        35                  40                  45              


Ser Thr Cys Glu Gln Leu Ala Lys Ala Asn Ala Gly Lys Pro Lys Asp 
    50                  55                  60                  


Pro Thr Phe Ile Pro Ala Pro Ile Gln Ala Lys Thr Ser Pro Val Asp 
65                  70                  75                  80  


Glu Lys Ala Leu Gln Asp Gln Leu Val Leu Val Ala Ala Lys Leu Asp 
                85                  90                  95      


Thr Glu Asp Lys Leu Arg Ala Ala Met Val Gly Met Leu Ala Asn Phe 
            100                 105                 110         


Leu Gly Phe Arg Ile Tyr Gly Met His Ser Glu Leu Trp Gly Val Val 
        115                 120                 125             


His Gly Ala Thr Val Leu Ser Pro Thr Ala Val Phe Gly Thr Leu Ala 
    130                 135                 140                 


Ser Leu Tyr Leu Gly Ala Leu Asp His Thr Ala Asp Arg Leu Gln Ala 
145                 150                 155                 160 


Ile Leu Gly Val Pro Trp Lys Asp Lys Asn Cys Thr Ser Arg Leu Asp 
                165                 170                 175     


Ala His Lys Val Leu Ser Ala Leu Gln Ala Val Gln Gly Leu Leu Val 
            180                 185                 190         


Ala Gln Gly Arg Ala Asp Ser Gln Ala Gln Leu Leu Leu Ser Thr Val 
        195                 200                 205             


Val Gly Val Phe Thr Ala Pro Gly Leu His Leu Lys Gln Pro Phe Val 
    210                 215                 220                 


Gln Gly Leu Ala Leu Tyr Thr Pro Val Val Leu Pro Arg Ser Leu Asp 
225                 230                 235                 240 


Phe Thr Glu Leu Asp Val Ala Ala Glu Lys Ile Asp Arg Phe Met Gln 
                245                 250                 255     


Ala Val Thr Gly Trp Lys Thr Gly Cys Ser Leu Met Gly Ala Ser Val 
            260                 265                 270         


Asp Ser Thr Leu Ala Phe Asn Thr Tyr Val His Phe Gln Gly Lys Met 
        275                 280                 285             


Lys Gly Phe Ser Leu Leu Ala Glu Pro Gln Glu Phe Trp Val Asp Asn 
    290                 295                 300                 


Ser Thr Ser Val Ser Val Pro Met Leu Ser Gly Met Gly Thr Phe Gln 
305                 310                 315                 320 


His Trp Ser Asp Ile Gln Asp Asn Phe Ser Val Thr Gln Val Pro Phe 
                325                 330                 335     


Thr Glu Ser Ala Cys Leu Leu Leu Ile Gln Pro His Tyr Ala Ser Asp 
            340                 345                 350         


Leu Asp Lys Val Glu Gly Leu Thr Phe Gln Gln Asn Ser Leu Asn Trp 
        355                 360                 365             


Met Lys Lys Leu Ser Pro Arg Thr Ile His Leu Thr Met Pro Gln Leu 
    370                 375                 380                 


Val Leu Gln Gly Ser Tyr Asp Leu Gln Asp Leu Leu Ala Gln Ala Glu 
385                 390                 395                 400 


Leu Pro Ala Ile Leu His Thr Glu Leu Asn Leu Gln Lys Leu Ser Asn 
                405                 410                 415     


Asp Arg Ile Arg Val Gly Glu Val Leu Asn Ser Ile Phe Phe Glu Leu 
            420                 425                 430         


Glu Ala Asp Glu Arg Glu Pro Thr Glu Ser Thr Gln Gln Leu Asn Lys 
        435                 440                 445             


Pro Glu Val Leu Glu Val Thr Leu Asn Arg Pro Phe Leu Phe Ala Val 
    450                 455                 460                 


Tyr Asp Gln Ser Ala Thr Ala Leu His Phe Leu Gly Arg Val Ala Asn 
465                 470                 475                 480 


Pro Leu Ser Thr Ala 
                485 


<210>  624
<211>  1278
<212>  PRT
<213>  Homo Sapiens

<400>  624

Met Arg Thr Gly Ser Ala Ala Ser Ser Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Ser Ala Ser Pro Ala Thr Gly Val Cys Met Lys Thr Pro 
            20                  25                  30          


Gly Gly Gly Arg Arg Gly Ile Arg Arg Asp Pro Gly Ala Glu Pro Gly 
        35                  40                  45              


Ala Ala Ala Leu Arg Gly Pro Arg Gln Arg Pro Ile Leu Ser Arg Leu 
    50                  55                  60                  


Thr Asn Asn Ser Arg Ile Val Gly Leu Leu Ala Gln Leu Glu Lys Ile 
65                  70                  75                  80  


Asn Ala Glu Pro Ser Glu Ser Asp Thr Ala Arg Tyr Val Thr Ser Lys 
                85                  90                  95      


Ile Leu His Leu Ala Gln Ser Gln Glu Lys Thr Arg Arg Glu Met Thr 
            100                 105                 110         


Ala Lys Gly Ser Thr Gly Met Glu Ile Leu Leu Ser Thr Leu Glu Asn 
        115                 120                 125             


Thr Lys Asp Leu Gln Thr Thr Leu Asn Ile Leu Ser Ile Leu Val Glu 
    130                 135                 140                 


Leu Val Ser Ala Gly Gly Gly Arg Arg Val Ser Phe Leu Val Thr Lys 
145                 150                 155                 160 


Gly Gly Ser Gln Ile Leu Leu Gln Leu Leu Met Asn Ala Ser Lys Glu 
                165                 170                 175     


Ser Pro Pro His Glu Asp Leu Met Val Gln Ile His Ser Ile Leu Ala 
            180                 185                 190         


Lys Ile Gly Pro Lys Asp Lys Lys Phe Gly Val Lys Ala Arg Ile Asn 
        195                 200                 205             


Gly Ala Leu Asn Ile Thr Leu Asn Leu Val Lys Gln Asn Leu Gln Asn 
    210                 215                 220                 


His Arg Leu Val Leu Pro Cys Leu Gln Leu Leu Arg Val Tyr Ser Ala 
225                 230                 235                 240 


Asn Ser Val Asn Ser Val Ser Leu Gly Lys Asn Gly Val Val Glu Leu 
                245                 250                 255     


Met Phe Lys Ile Ile Gly Pro Phe Ser Lys Lys Asn Ser Ser Leu Ile 
            260                 265                 270         


Lys Val Ala Leu Asp Thr Leu Ala Ala Leu Leu Lys Ser Lys Thr Asn 
        275                 280                 285             


Ala Arg Arg Ala Val Asp Arg Gly Tyr Val Gln Val Leu Leu Thr Ile 
    290                 295                 300                 


Tyr Val Asp Trp His Arg His Asp Asn Arg His Arg Asn Met Leu Ile 
305                 310                 315                 320 


Arg Lys Gly Ile Leu Gln Ser Leu Lys Ser Val Thr Asn Ile Lys Leu 
                325                 330                 335     


Gly Arg Lys Ala Phe Ile Asp Ala Asn Gly Met Lys Ile Leu Tyr Asn 
            340                 345                 350         


Thr Ser Gln Glu Cys Leu Ala Val Arg Thr Leu Asp Pro Leu Val Asn 
        355                 360                 365             


Thr Ser Ser Leu Ile Met Arg Lys Cys Phe Pro Lys Asn Arg Leu Pro 
    370                 375                 380                 


Leu Pro Thr Ile Lys Ser Ser Phe His Phe Gln Leu Pro Val Ile Pro 
385                 390                 395                 400 


Val Thr Gly Pro Val Ala Gln Leu Tyr Ser Leu Pro Pro Glu Val Asp 
                405                 410                 415     


Asp Val Val Asp Glu Ser Asp Asp Asn Asp Asp Ile Asp Val Glu Ala 
            420                 425                 430         


Glu Asn Glu Thr Glu Asn Glu Asp Asp Leu Asp Gln Asn Phe Lys Asn 
        435                 440                 445             


Asp Asp Ile Glu Thr Asp Ile Asn Lys Leu Lys Pro Gln Gln Glu Pro 
    450                 455                 460                 


Gly Arg Thr Ile Glu Asp Leu Lys Met Tyr Glu His Leu Phe Pro Glu 
465                 470                 475                 480 


Leu Val Asp Asp Phe Gln Asp Tyr Asp Leu Ile Ser Lys Glu Pro Lys 
                485                 490                 495     


Pro Phe Val Phe Glu Gly Lys Val Arg Gly Pro Ile Val Val Pro Thr 
            500                 505                 510         


Ala Gly Glu Glu Thr Ser Gly Asn Ser Gly Asn Leu Arg Lys Val Val 
        515                 520                 525             


Met Lys Glu Asn Ile Ser Ser Lys Gly Asp Glu Gly Glu Lys Lys Ser 
    530                 535                 540                 


Thr Phe Met Asp Leu Ala Lys Glu Asp Ile Lys Asp Asn Asp Arg Thr 
545                 550                 555                 560 


Leu Gln Gln Gln Pro Gly Asp Gln Asn Arg Thr Ile Ser Ser Val His 
                565                 570                 575     


Gly Leu Asn Asn Asp Ile Val Lys Ala Leu Asp Arg Ile Thr Leu Gln 
            580                 585                 590         


Asn Ile Pro Ser Gln Thr Ala Pro Gly Phe Thr Ala Glu Met Lys Lys 
        595                 600                 605             


Asp Cys Ser Leu Pro Leu Thr Val Leu Thr Cys Ala Lys Ala Cys Pro 
    610                 615                 620                 


His Met Ala Thr Cys Gly Asn Val Leu Phe Glu Gly Arg Thr Val Gln 
625                 630                 635                 640 


Leu Gly Lys Leu Cys Cys Thr Gly Val Glu Thr Glu Asp Asp Glu Asp 
                645                 650                 655     


Thr Glu Ser Asn Ser Ser Val Glu Gln Ala Ser Val Glu Val Pro Asp 
            660                 665                 670         


Gly Pro Thr Leu His Asp Pro Asp Leu Tyr Ile Glu Ile Val Lys Asn 
        675                 680                 685             


Thr Lys Ser Val Pro Glu Tyr Ser Glu Val Ala Tyr Pro Asp Tyr Phe 
    690                 695                 700                 


Gly His Ile Pro Pro Pro Phe Lys Glu Pro Ile Leu Glu Arg Pro Tyr 
705                 710                 715                 720 


Gly Val Gln Arg Thr Lys Ile Ala Gln Asp Ile Glu Arg Leu Ile His 
                725                 730                 735     


Gln Ser Asp Ile Ile Asp Arg Val Val Tyr Asp Leu Asp Asn Pro Asn 
            740                 745                 750         


Tyr Thr Ile Pro Glu Glu Gly Asp Ile Leu Lys Phe Asn Ser Lys Phe 
        755                 760                 765             


Glu Ser Gly Asn Leu Arg Lys Val Ile Gln Ile Arg Lys Asn Glu Tyr 
    770                 775                 780                 


Asp Leu Ile Leu Asn Ser Asp Ile Asn Ser Asn His Tyr His Gln Trp 
785                 790                 795                 800 


Phe Tyr Phe Glu Val Ser Gly Met Arg Pro Gly Val Ala Tyr Arg Phe 
                805                 810                 815     


Asn Ile Ile Asn Cys Glu Lys Ser Asn Ser Gln Phe Asn Tyr Gly Met 
            820                 825                 830         


Gln Pro Leu Met Tyr Ser Val Gln Glu Ala Leu Asn Ala Arg Pro Trp 
        835                 840                 845             


Trp Ile Arg Met Gly Thr Asp Ile Cys Tyr Tyr Lys Asn His Phe Ser 
    850                 855                 860                 


Arg Ser Ser Val Ala Ala Gly Gly Gln Lys Gly Lys Ser Tyr Tyr Thr 
865                 870                 875                 880 


Ile Thr Phe Thr Val Asn Phe Pro His Lys Asp Asp Val Cys Tyr Phe 
                885                 890                 895     


Ala Tyr His Tyr Pro Tyr Thr Tyr Ser Thr Leu Gln Met His Leu Gln 
            900                 905                 910         


Lys Leu Glu Ser Ala His Asn Pro Gln Gln Ile Tyr Phe Arg Lys Asp 
        915                 920                 925             


Val Leu Cys Glu Thr Leu Ser Gly Asn Ser Cys Pro Leu Val Thr Ile 
    930                 935                 940                 


Thr Ala Met Pro Glu Ser Asn Tyr Tyr Glu His Ile Cys His Phe Arg 
945                 950                 955                 960 


Asn Arg Pro Tyr Val Phe Leu Ser Ala Arg Val His Pro Gly Glu Thr 
                965                 970                 975     


Asn Ala Ser Trp Val Met Lys Gly Thr Leu Glu Tyr Leu Met Ser Asn 
            980                 985                 990         


Asn Pro Thr Ala Gln Ser Leu Arg  Glu Ser Tyr Ile Phe  Lys Ile Val 
        995                 1000                 1005             


Pro Met  Leu Asn Pro Asp Gly  Val Ile Asn Gly Asn  His Arg Cys 
    1010                 1015                 1020             


Ser Leu  Ser Gly Glu Asp Leu  Asn Arg Gln Trp Gln  Ser Pro Ser 
    1025                 1030                 1035             


Pro Asp  Leu His Pro Thr Ile  Tyr His Ala Lys Gly  Leu Leu Gln 
    1040                 1045                 1050             


Tyr Leu  Ala Ala Val Lys Arg  Leu Pro Leu Val Tyr  Cys Asp Tyr 
    1055                 1060                 1065             


His Gly  His Ser Arg Lys Lys  Asn Val Phe Met Tyr  Gly Cys Ser 
    1070                 1075                 1080             


Ile Lys  Glu Thr Val Trp His  Thr Asn Asp Asn Ala  Thr Ser Cys 
    1085                 1090                 1095             


Asp Val  Val Glu Asp Thr Gly  Tyr Arg Thr Leu Pro  Lys Ile Leu 
    1100                 1105                 1110             


Ser His  Ile Ala Pro Ala Phe  Cys Met Ser Ser Cys  Ser Phe Val 
    1115                 1120                 1125             


Val Glu  Lys Ser Lys Glu Ser  Thr Ala Arg Val Val  Val Trp Arg 
    1130                 1135                 1140             


Glu Ile  Gly Val Gln Arg Ser  Tyr Thr Met Glu Ser  Thr Leu Cys 
    1145                 1150                 1155             


Gly Cys  Asp Gln Gly Lys Tyr  Lys Gly Leu Gln Ile  Gly Thr Arg 
    1160                 1165                 1170             


Glu Leu  Glu Glu Met Gly Ala  Lys Phe Cys Val Gly  Leu Leu Arg 
    1175                 1180                 1185             


Leu Lys  Arg Leu Thr Ser Pro  Leu Glu Tyr Asn Leu  Pro Ser Ser 
    1190                 1195                 1200             


Leu Leu  Asp Phe Glu Asn Asp  Leu Ile Glu Ser Ser  Cys Lys Val 
    1205                 1210                 1215             


Thr Ser  Pro Thr Thr Tyr Val  Leu Asp Glu Asp Glu  Pro Arg Phe 
    1220                 1225                 1230             


Leu Glu  Glu Val Asp Tyr Ser  Ala Glu Ser Asn Asp  Glu Leu Asp 
    1235                 1240                 1245             


Ile Glu  Leu Ala Glu Asn Val  Gly Asp Tyr Glu Pro  Ser Ala Gln 
    1250                 1255                 1260             


Glu Glu  Val Leu Ser Asp Ser  Glu Leu Ser Arg Thr  Tyr Leu Pro 
    1265                 1270                 1275             


<210>  625
<211>  1238
<212>  PRT
<213>  Homo Sapiens

<400>  625

Met Arg Thr Gly Ser Ala Ala Ser Ser Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Ser Ala Ser Pro Ala Thr Gly Val Cys Met Lys Thr Pro 
            20                  25                  30          


Gly Gly Gly Arg Arg Gly Ile Arg Arg Asp Pro Gly Ala Glu Pro Gly 
        35                  40                  45              


Ala Ala Ala Leu Arg Gly Pro Arg Gln Arg Pro Ile Leu Ser Arg Leu 
    50                  55                  60                  


Thr Asn Asn Ser Arg Ile Val Gly Leu Leu Ala Gln Leu Glu Lys Ile 
65                  70                  75                  80  


Asn Ala Glu Pro Ser Glu Ser Asp Thr Ala Arg Tyr Val Thr Ser Lys 
                85                  90                  95      


Ile Leu His Leu Ala Gln Ser Gln Glu Lys Thr Arg Arg Glu Met Thr 
            100                 105                 110         


Ala Lys Gly Ser Thr Gly Met Glu Ile Leu Leu Ser Thr Leu Glu Asn 
        115                 120                 125             


Thr Lys Asp Leu Gln Thr Thr Leu Asn Ile Leu Ser Ile Leu Val Glu 
    130                 135                 140                 


Leu Val Ser Ala Gly Gly Gly Arg Arg Val Ser Phe Leu Val Thr Lys 
145                 150                 155                 160 


Gly Gly Ser Gln Ile Leu Leu Gln Leu Leu Met Asn Ala Ser Lys Glu 
                165                 170                 175     


Ser Pro Pro His Glu Asp Leu Met Val Gln Ile His Ser Ile Leu Ala 
            180                 185                 190         


Lys Ile Gly Pro Lys Asp Lys Lys Phe Gly Val Lys Ala Arg Ile Asn 
        195                 200                 205             


Gly Ala Leu Asn Ile Thr Leu Asn Leu Val Lys Gln Asn Leu Gln Asn 
    210                 215                 220                 


His Arg Leu Val Leu Pro Cys Leu Gln Leu Leu Arg Val Tyr Ser Ala 
225                 230                 235                 240 


Asn Ser Val Asn Ser Val Ser Leu Gly Lys Asn Gly Val Val Glu Leu 
                245                 250                 255     


Met Phe Lys Ile Ile Gly Pro Phe Ser Lys Lys Asn Ser Ser Leu Ile 
            260                 265                 270         


Lys Val Ala Leu Asp Thr Leu Ala Ala Leu Leu Lys Ser Lys Thr Asn 
        275                 280                 285             


Ala Arg Arg Ala Val Asp Arg Gly Tyr Val Gln Val Leu Leu Thr Ile 
    290                 295                 300                 


Tyr Val Asp Trp His Arg His Asp Asn Arg His Arg Asn Met Leu Ile 
305                 310                 315                 320 


Arg Lys Gly Ile Leu Gln Ser Leu Lys Ser Val Thr Asn Ile Lys Leu 
                325                 330                 335     


Gly Arg Lys Ala Phe Ile Asp Ala Asn Gly Met Lys Ile Leu Tyr Asn 
            340                 345                 350         


Thr Ser Gln Leu Pro Val Ile Pro Val Thr Gly Pro Val Ala Gln Leu 
        355                 360                 365             


Tyr Ser Leu Pro Pro Glu Val Asp Asp Val Val Asp Glu Ser Asp Asp 
    370                 375                 380                 


Asn Asp Asp Ile Asp Val Glu Ala Glu Asn Glu Thr Glu Asn Glu Asp 
385                 390                 395                 400 


Asp Leu Asp Gln Asn Phe Lys Asn Asp Asp Ile Glu Thr Asp Ile Asn 
                405                 410                 415     


Lys Leu Lys Pro Gln Gln Glu Pro Gly Arg Thr Ile Glu Asp Leu Lys 
            420                 425                 430         


Met Tyr Glu His Leu Phe Pro Glu Leu Val Asp Asp Phe Gln Asp Tyr 
        435                 440                 445             


Asp Leu Ile Ser Lys Glu Pro Lys Pro Phe Val Phe Glu Gly Lys Val 
    450                 455                 460                 


Arg Gly Pro Ile Val Val Pro Thr Ala Gly Glu Glu Thr Ser Gly Asn 
465                 470                 475                 480 


Ser Gly Asn Leu Arg Lys Val Val Met Lys Glu Asn Ile Ser Ser Lys 
                485                 490                 495     


Gly Asp Glu Gly Glu Lys Lys Ser Thr Phe Met Asp Leu Ala Lys Glu 
            500                 505                 510         


Asp Ile Lys Asp Asn Asp Arg Thr Leu Gln Gln Gln Pro Gly Asp Gln 
        515                 520                 525             


Asn Arg Thr Ile Ser Ser Val His Gly Leu Asn Asn Asp Ile Val Lys 
    530                 535                 540                 


Ala Leu Asp Arg Ile Thr Leu Gln Asn Ile Pro Ser Gln Thr Ala Pro 
545                 550                 555                 560 


Gly Phe Thr Ala Glu Met Lys Lys Asp Cys Ser Leu Pro Leu Thr Val 
                565                 570                 575     


Leu Thr Cys Ala Lys Ala Cys Pro His Met Ala Thr Cys Gly Asn Val 
            580                 585                 590         


Leu Phe Glu Gly Arg Thr Val Gln Leu Gly Lys Leu Cys Cys Thr Gly 
        595                 600                 605             


Val Glu Thr Glu Asp Asp Glu Asp Thr Glu Ser Asn Ser Ser Val Glu 
    610                 615                 620                 


Gln Ala Ser Val Glu Val Pro Asp Gly Pro Thr Leu His Asp Pro Asp 
625                 630                 635                 640 


Leu Tyr Ile Glu Ile Val Lys Asn Thr Lys Ser Val Pro Glu Tyr Ser 
                645                 650                 655     


Glu Val Ala Tyr Pro Asp Tyr Phe Gly His Ile Pro Pro Pro Phe Lys 
            660                 665                 670         


Glu Pro Ile Leu Glu Arg Pro Tyr Gly Val Gln Arg Thr Lys Ile Ala 
        675                 680                 685             


Gln Asp Ile Glu Arg Leu Ile His Gln Ser Asp Ile Ile Asp Arg Val 
    690                 695                 700                 


Val Tyr Asp Leu Asp Asn Pro Asn Tyr Thr Ile Pro Glu Glu Gly Asp 
705                 710                 715                 720 


Ile Leu Lys Phe Asn Ser Lys Phe Glu Ser Gly Asn Leu Arg Lys Val 
                725                 730                 735     


Ile Gln Ile Arg Lys Asn Glu Tyr Asp Leu Ile Leu Asn Ser Asp Ile 
            740                 745                 750         


Asn Ser Asn His Tyr His Gln Trp Phe Tyr Phe Glu Val Ser Gly Met 
        755                 760                 765             


Arg Pro Gly Val Ala Tyr Arg Phe Asn Ile Ile Asn Cys Glu Lys Ser 
    770                 775                 780                 


Asn Ser Gln Phe Asn Tyr Gly Met Gln Pro Leu Met Tyr Ser Val Gln 
785                 790                 795                 800 


Glu Ala Leu Asn Ala Arg Pro Trp Trp Ile Arg Met Gly Thr Asp Ile 
                805                 810                 815     


Cys Tyr Tyr Lys Asn His Phe Ser Arg Ser Ser Val Ala Ala Gly Gly 
            820                 825                 830         


Gln Lys Gly Lys Ser Tyr Tyr Thr Ile Thr Phe Thr Val Asn Phe Pro 
        835                 840                 845             


His Lys Asp Asp Val Cys Tyr Phe Ala Tyr His Tyr Pro Tyr Thr Tyr 
    850                 855                 860                 


Ser Thr Leu Gln Met His Leu Gln Lys Leu Glu Ser Ala His Asn Pro 
865                 870                 875                 880 


Gln Gln Ile Tyr Phe Arg Lys Asp Val Leu Cys Glu Thr Leu Ser Gly 
                885                 890                 895     


Asn Ser Cys Pro Leu Val Thr Ile Thr Ala Met Pro Glu Ser Asn Tyr 
            900                 905                 910         


Tyr Glu His Ile Cys His Phe Arg Asn Arg Pro Tyr Val Phe Leu Ser 
        915                 920                 925             


Ala Arg Val His Pro Gly Glu Thr Asn Ala Ser Trp Val Met Lys Gly 
    930                 935                 940                 


Thr Leu Glu Tyr Leu Met Ser Asn Asn Pro Thr Ala Gln Ser Leu Arg 
945                 950                 955                 960 


Glu Ser Tyr Ile Phe Lys Ile Val Pro Met Leu Asn Pro Asp Gly Val 
                965                 970                 975     


Ile Asn Gly Asn His Arg Cys Ser Leu Ser Gly Glu Asp Leu Asn Arg 
            980                 985                 990         


Gln Trp Gln Ser Pro Ser Pro Asp  Leu His Pro Thr Ile  Tyr His Ala 
        995                 1000                 1005             


Lys Gly  Leu Leu Gln Tyr Leu  Ala Ala Val Lys Arg  Leu Pro Leu 
    1010                 1015                 1020             


Val Tyr  Cys Asp Tyr His Gly  His Ser Arg Lys Lys  Asn Val Phe 
    1025                 1030                 1035             


Met Tyr  Gly Cys Ser Ile Lys  Glu Thr Val Trp His  Thr Asn Asp 
    1040                 1045                 1050             


Asn Ala  Thr Ser Cys Asp Val  Val Glu Asp Thr Gly  Tyr Arg Thr 
    1055                 1060                 1065             


Leu Pro  Lys Ile Leu Ser His  Ile Ala Pro Ala Phe  Cys Met Ser 
    1070                 1075                 1080             


Ser Cys  Ser Phe Val Val Glu  Lys Ser Lys Glu Ser  Thr Ala Arg 
    1085                 1090                 1095             


Val Val  Val Trp Arg Glu Ile  Gly Val Gln Arg Ser  Tyr Thr Met 
    1100                 1105                 1110             


Glu Ser  Thr Leu Cys Gly Cys  Asp Gln Gly Lys Tyr  Lys Gly Leu 
    1115                 1120                 1125             


Gln Ile  Gly Thr Arg Glu Leu  Glu Glu Met Gly Ala  Lys Phe Cys 
    1130                 1135                 1140             


Val Gly  Leu Leu Arg Leu Lys  Arg Leu Thr Ser Pro  Leu Glu Tyr 
    1145                 1150                 1155             


Asn Leu  Pro Ser Ser Leu Leu  Asp Phe Glu Asn Asp  Leu Ile Glu 
    1160                 1165                 1170             


Ser Ser  Cys Lys Val Thr Ser  Pro Thr Thr Tyr Val  Leu Asp Glu 
    1175                 1180                 1185             


Asp Glu  Pro Arg Phe Leu Glu  Glu Val Asp Tyr Ser  Ala Glu Ser 
    1190                 1195                 1200             


Asn Asp  Glu Leu Asp Ile Glu  Leu Ala Glu Asn Val  Gly Asp Tyr 
    1205                 1210                 1215             


Glu Pro  Ser Ala Gln Glu Glu  Val Leu Ser Asp Ser  Glu Leu Ser 
    1220                 1225                 1230             


Arg Thr  Tyr Leu Pro 
    1235             


<210>  626
<211>  1226
<212>  PRT
<213>  Homo Sapiens

<400>  626

Met Ser Lys Leu Lys Val Ile Pro Glu Lys Ser Leu Thr Asn Asn Ser 
1               5                   10                  15      


Arg Ile Val Gly Leu Leu Ala Gln Leu Glu Lys Ile Asn Ala Glu Pro 
            20                  25                  30          


Ser Glu Ser Asp Thr Ala Arg Tyr Val Thr Ser Lys Ile Leu His Leu 
        35                  40                  45              


Ala Gln Ser Gln Glu Lys Thr Arg Arg Glu Met Thr Ala Lys Gly Ser 
    50                  55                  60                  


Thr Gly Met Glu Ile Leu Leu Ser Thr Leu Glu Asn Thr Lys Asp Leu 
65                  70                  75                  80  


Gln Thr Thr Leu Asn Ile Leu Ser Ile Leu Val Glu Leu Val Ser Ala 
                85                  90                  95      


Gly Gly Gly Arg Arg Val Ser Phe Leu Val Thr Lys Gly Gly Ser Gln 
            100                 105                 110         


Ile Leu Leu Gln Leu Leu Met Asn Ala Ser Lys Glu Ser Pro Pro His 
        115                 120                 125             


Glu Asp Leu Met Val Gln Ile His Ser Ile Leu Ala Lys Ile Gly Pro 
    130                 135                 140                 


Lys Asp Lys Lys Phe Gly Val Lys Ala Arg Ile Asn Gly Ala Leu Asn 
145                 150                 155                 160 


Ile Thr Leu Asn Leu Val Lys Gln Asn Leu Gln Asn His Arg Leu Val 
                165                 170                 175     


Leu Pro Cys Leu Gln Leu Leu Arg Val Tyr Ser Ala Asn Ser Val Asn 
            180                 185                 190         


Ser Val Ser Leu Gly Lys Asn Gly Val Val Glu Leu Met Phe Lys Ile 
        195                 200                 205             


Ile Gly Pro Phe Ser Lys Lys Asn Ser Ser Leu Ile Lys Val Ala Leu 
    210                 215                 220                 


Asp Thr Leu Ala Ala Leu Leu Lys Ser Lys Thr Asn Ala Arg Arg Ala 
225                 230                 235                 240 


Val Asp Arg Gly Tyr Val Gln Val Leu Leu Thr Ile Tyr Val Asp Trp 
                245                 250                 255     


His Arg His Asp Asn Arg His Arg Asn Met Leu Ile Arg Lys Gly Ile 
            260                 265                 270         


Leu Gln Ser Leu Lys Ser Val Thr Asn Ile Lys Leu Gly Arg Lys Ala 
        275                 280                 285             


Phe Ile Asp Ala Asn Gly Met Lys Ile Leu Tyr Asn Thr Ser Gln Glu 
    290                 295                 300                 


Cys Leu Ala Val Arg Thr Leu Asp Pro Leu Val Asn Thr Ser Ser Leu 
305                 310                 315                 320 


Ile Met Arg Lys Cys Phe Pro Lys Asn Arg Leu Pro Leu Pro Thr Ile 
                325                 330                 335     


Lys Ser Ser Phe His Phe Gln Leu Pro Val Ile Pro Val Thr Gly Pro 
            340                 345                 350         


Val Ala Gln Leu Tyr Ser Leu Pro Pro Glu Val Asp Asp Val Val Asp 
        355                 360                 365             


Glu Ser Asp Asp Asn Asp Asp Ile Asp Val Glu Ala Glu Asn Glu Thr 
    370                 375                 380                 


Glu Asn Glu Asp Asp Leu Asp Gln Asn Phe Lys Asn Asp Asp Ile Glu 
385                 390                 395                 400 


Thr Asp Ile Asn Lys Leu Lys Pro Gln Gln Glu Pro Gly Arg Thr Ile 
                405                 410                 415     


Glu Asp Leu Lys Met Tyr Glu His Leu Phe Pro Glu Leu Val Asp Asp 
            420                 425                 430         


Phe Gln Asp Tyr Asp Leu Ile Ser Lys Glu Pro Lys Pro Phe Val Phe 
        435                 440                 445             


Glu Gly Lys Val Arg Gly Pro Ile Val Val Pro Thr Ala Gly Glu Glu 
    450                 455                 460                 


Thr Ser Gly Asn Ser Gly Asn Leu Arg Lys Val Val Met Lys Glu Asn 
465                 470                 475                 480 


Ile Ser Ser Lys Gly Asp Glu Gly Glu Lys Lys Ser Thr Phe Met Asp 
                485                 490                 495     


Leu Ala Lys Glu Asp Ile Lys Asp Asn Asp Arg Thr Leu Gln Gln Gln 
            500                 505                 510         


Pro Gly Asp Gln Asn Arg Thr Ile Ser Ser Val His Gly Leu Asn Asn 
        515                 520                 525             


Asp Ile Val Lys Ala Leu Asp Arg Ile Thr Leu Gln Asn Ile Pro Ser 
    530                 535                 540                 


Gln Thr Ala Pro Gly Phe Thr Ala Glu Met Lys Lys Asp Cys Ser Leu 
545                 550                 555                 560 


Pro Leu Thr Val Leu Thr Cys Ala Lys Ala Cys Pro His Met Ala Thr 
                565                 570                 575     


Cys Gly Asn Val Leu Phe Glu Gly Arg Thr Val Gln Leu Gly Lys Leu 
            580                 585                 590         


Cys Cys Thr Gly Val Glu Thr Glu Asp Asp Glu Asp Thr Glu Ser Asn 
        595                 600                 605             


Ser Ser Val Glu Gln Ala Ser Val Glu Val Pro Asp Gly Pro Thr Leu 
    610                 615                 620                 


His Asp Pro Asp Leu Tyr Ile Glu Ile Val Lys Asn Thr Lys Ser Val 
625                 630                 635                 640 


Pro Glu Tyr Ser Glu Val Ala Tyr Pro Asp Tyr Phe Gly His Ile Pro 
                645                 650                 655     


Pro Pro Phe Lys Glu Pro Ile Leu Glu Arg Pro Tyr Gly Val Gln Arg 
            660                 665                 670         


Thr Lys Ile Ala Gln Asp Ile Glu Arg Leu Ile His Gln Ser Asp Ile 
        675                 680                 685             


Ile Asp Arg Val Val Tyr Asp Leu Asp Asn Pro Asn Tyr Thr Ile Pro 
    690                 695                 700                 


Glu Glu Gly Asp Ile Leu Lys Phe Asn Ser Lys Phe Glu Ser Gly Asn 
705                 710                 715                 720 


Leu Arg Lys Val Ile Gln Ile Arg Lys Asn Glu Tyr Asp Leu Ile Leu 
                725                 730                 735     


Asn Ser Asp Ile Asn Ser Asn His Tyr His Gln Trp Phe Tyr Phe Glu 
            740                 745                 750         


Val Ser Gly Met Arg Pro Gly Val Ala Tyr Arg Phe Asn Ile Ile Asn 
        755                 760                 765             


Cys Glu Lys Ser Asn Ser Gln Phe Asn Tyr Gly Met Gln Pro Leu Met 
    770                 775                 780                 


Tyr Ser Val Gln Glu Ala Leu Asn Ala Arg Pro Trp Trp Ile Arg Met 
785                 790                 795                 800 


Gly Thr Asp Ile Cys Tyr Tyr Lys Asn His Phe Ser Arg Ser Ser Val 
                805                 810                 815     


Ala Ala Gly Gly Gln Lys Gly Lys Ser Tyr Tyr Thr Ile Thr Phe Thr 
            820                 825                 830         


Val Asn Phe Pro His Lys Asp Asp Val Cys Tyr Phe Ala Tyr His Tyr 
        835                 840                 845             


Pro Tyr Thr Tyr Ser Thr Leu Gln Met His Leu Gln Lys Leu Glu Ser 
    850                 855                 860                 


Ala His Asn Pro Gln Gln Ile Tyr Phe Arg Lys Asp Val Leu Cys Glu 
865                 870                 875                 880 


Thr Leu Ser Gly Asn Ser Cys Pro Leu Val Thr Ile Thr Ala Met Pro 
                885                 890                 895     


Glu Ser Asn Tyr Tyr Glu His Ile Cys His Phe Arg Asn Arg Pro Tyr 
            900                 905                 910         


Val Phe Leu Ser Ala Arg Val His Pro Gly Glu Thr Asn Ala Ser Trp 
        915                 920                 925             


Val Met Lys Gly Thr Leu Glu Tyr Leu Met Ser Asn Asn Pro Thr Ala 
    930                 935                 940                 


Gln Ser Leu Arg Glu Ser Tyr Ile Phe Lys Ile Val Pro Met Leu Asn 
945                 950                 955                 960 


Pro Asp Gly Val Ile Asn Gly Asn His Arg Cys Ser Leu Ser Gly Glu 
                965                 970                 975     


Asp Leu Asn Arg Gln Trp Gln Ser Pro Ser Pro Asp Leu His Pro Thr 
            980                 985                 990         


Ile Tyr His Ala Lys Gly Leu Leu  Gln Tyr Leu Ala Ala  Val Lys Arg 
        995                 1000                 1005             


Leu Pro  Leu Val Tyr Cys Asp  Tyr His Gly His Ser  Arg Lys Lys 
    1010                 1015                 1020             


Asn Val  Phe Met Tyr Gly Cys  Ser Ile Lys Glu Thr  Val Trp His 
    1025                 1030                 1035             


Thr Asn  Asp Asn Ala Thr Ser  Cys Asp Val Val Glu  Asp Thr Gly 
    1040                 1045                 1050             


Tyr Arg  Thr Leu Pro Lys Ile  Leu Ser His Ile Ala  Pro Ala Phe 
    1055                 1060                 1065             


Cys Met  Ser Ser Cys Ser Phe  Val Val Glu Lys Ser  Lys Glu Ser 
    1070                 1075                 1080             


Thr Ala  Arg Val Val Val Trp  Arg Glu Ile Gly Val  Gln Arg Ser 
    1085                 1090                 1095             


Tyr Thr  Met Glu Ser Thr Leu  Cys Gly Cys Asp Gln  Gly Lys Tyr 
    1100                 1105                 1110             


Lys Gly  Leu Gln Ile Gly Thr  Arg Glu Leu Glu Glu  Met Gly Ala 
    1115                 1120                 1125             


Lys Phe  Cys Val Gly Leu Leu  Arg Leu Lys Arg Leu  Thr Ser Pro 
    1130                 1135                 1140             


Leu Glu  Tyr Asn Leu Pro Ser  Ser Leu Leu Asp Phe  Glu Asn Asp 
    1145                 1150                 1155             


Leu Ile  Glu Ser Ser Cys Lys  Val Thr Ser Pro Thr  Thr Tyr Val 
    1160                 1165                 1170             


Leu Asp  Glu Asp Glu Pro Arg  Phe Leu Glu Glu Val  Asp Tyr Ser 
    1175                 1180                 1185             


Ala Glu  Ser Asn Asp Glu Leu  Asp Ile Glu Leu Ala  Glu Asn Val 
    1190                 1195                 1200             


Gly Asp  Tyr Glu Pro Ser Ala  Gln Glu Glu Val Leu  Ser Asp Ser 
    1205                 1210                 1215             


Glu Leu  Ser Arg Thr Tyr Leu  Pro 
    1220                 1225     


<210>  627
<211>  1186
<212>  PRT
<213>  Homo Sapiens

<400>  627

Met Ser Lys Leu Lys Val Ile Pro Glu Lys Ser Leu Thr Asn Asn Ser 
1               5                   10                  15      


Arg Ile Val Gly Leu Leu Ala Gln Leu Glu Lys Ile Asn Ala Glu Pro 
            20                  25                  30          


Ser Glu Ser Asp Thr Ala Arg Tyr Val Thr Ser Lys Ile Leu His Leu 
        35                  40                  45              


Ala Gln Ser Gln Glu Lys Thr Arg Arg Glu Met Thr Ala Lys Gly Ser 
    50                  55                  60                  


Thr Gly Met Glu Ile Leu Leu Ser Thr Leu Glu Asn Thr Lys Asp Leu 
65                  70                  75                  80  


Gln Thr Thr Leu Asn Ile Leu Ser Ile Leu Val Glu Leu Val Ser Ala 
                85                  90                  95      


Gly Gly Gly Arg Arg Val Ser Phe Leu Val Thr Lys Gly Gly Ser Gln 
            100                 105                 110         


Ile Leu Leu Gln Leu Leu Met Asn Ala Ser Lys Glu Ser Pro Pro His 
        115                 120                 125             


Glu Asp Leu Met Val Gln Ile His Ser Ile Leu Ala Lys Ile Gly Pro 
    130                 135                 140                 


Lys Asp Lys Lys Phe Gly Val Lys Ala Arg Ile Asn Gly Ala Leu Asn 
145                 150                 155                 160 


Ile Thr Leu Asn Leu Val Lys Gln Asn Leu Gln Asn His Arg Leu Val 
                165                 170                 175     


Leu Pro Cys Leu Gln Leu Leu Arg Val Tyr Ser Ala Asn Ser Val Asn 
            180                 185                 190         


Ser Val Ser Leu Gly Lys Asn Gly Val Val Glu Leu Met Phe Lys Ile 
        195                 200                 205             


Ile Gly Pro Phe Ser Lys Lys Asn Ser Ser Leu Ile Lys Val Ala Leu 
    210                 215                 220                 


Asp Thr Leu Ala Ala Leu Leu Lys Ser Lys Thr Asn Ala Arg Arg Ala 
225                 230                 235                 240 


Val Asp Arg Gly Tyr Val Gln Val Leu Leu Thr Ile Tyr Val Asp Trp 
                245                 250                 255     


His Arg His Asp Asn Arg His Arg Asn Met Leu Ile Arg Lys Gly Ile 
            260                 265                 270         


Leu Gln Ser Leu Lys Ser Val Thr Asn Ile Lys Leu Gly Arg Lys Ala 
        275                 280                 285             


Phe Ile Asp Ala Asn Gly Met Lys Ile Leu Tyr Asn Thr Ser Gln Leu 
    290                 295                 300                 


Pro Val Ile Pro Val Thr Gly Pro Val Ala Gln Leu Tyr Ser Leu Pro 
305                 310                 315                 320 


Pro Glu Val Asp Asp Val Val Asp Glu Ser Asp Asp Asn Asp Asp Ile 
                325                 330                 335     


Asp Val Glu Ala Glu Asn Glu Thr Glu Asn Glu Asp Asp Leu Asp Gln 
            340                 345                 350         


Asn Phe Lys Asn Asp Asp Ile Glu Thr Asp Ile Asn Lys Leu Lys Pro 
        355                 360                 365             


Gln Gln Glu Pro Gly Arg Thr Ile Glu Asp Leu Lys Met Tyr Glu His 
    370                 375                 380                 


Leu Phe Pro Glu Leu Val Asp Asp Phe Gln Asp Tyr Asp Leu Ile Ser 
385                 390                 395                 400 


Lys Glu Pro Lys Pro Phe Val Phe Glu Gly Lys Val Arg Gly Pro Ile 
                405                 410                 415     


Val Val Pro Thr Ala Gly Glu Glu Thr Ser Gly Asn Ser Gly Asn Leu 
            420                 425                 430         


Arg Lys Val Val Met Lys Glu Asn Ile Ser Ser Lys Gly Asp Glu Gly 
        435                 440                 445             


Glu Lys Lys Ser Thr Phe Met Asp Leu Ala Lys Glu Asp Ile Lys Asp 
    450                 455                 460                 


Asn Asp Arg Thr Leu Gln Gln Gln Pro Gly Asp Gln Asn Arg Thr Ile 
465                 470                 475                 480 


Ser Ser Val His Gly Leu Asn Asn Asp Ile Val Lys Ala Leu Asp Arg 
                485                 490                 495     


Ile Thr Leu Gln Asn Ile Pro Ser Gln Thr Ala Pro Gly Phe Thr Ala 
            500                 505                 510         


Glu Met Lys Lys Asp Cys Ser Leu Pro Leu Thr Val Leu Thr Cys Ala 
        515                 520                 525             


Lys Ala Cys Pro His Met Ala Thr Cys Gly Asn Val Leu Phe Glu Gly 
    530                 535                 540                 


Arg Thr Val Gln Leu Gly Lys Leu Cys Cys Thr Gly Val Glu Thr Glu 
545                 550                 555                 560 


Asp Asp Glu Asp Thr Glu Ser Asn Ser Ser Val Glu Gln Ala Ser Val 
                565                 570                 575     


Glu Val Pro Asp Gly Pro Thr Leu His Asp Pro Asp Leu Tyr Ile Glu 
            580                 585                 590         


Ile Val Lys Asn Thr Lys Ser Val Pro Glu Tyr Ser Glu Val Ala Tyr 
        595                 600                 605             


Pro Asp Tyr Phe Gly His Ile Pro Pro Pro Phe Lys Glu Pro Ile Leu 
    610                 615                 620                 


Glu Arg Pro Tyr Gly Val Gln Arg Thr Lys Ile Ala Gln Asp Ile Glu 
625                 630                 635                 640 


Arg Leu Ile His Gln Ser Asp Ile Ile Asp Arg Val Val Tyr Asp Leu 
                645                 650                 655     


Asp Asn Pro Asn Tyr Thr Ile Pro Glu Glu Gly Asp Ile Leu Lys Phe 
            660                 665                 670         


Asn Ser Lys Phe Glu Ser Gly Asn Leu Arg Lys Val Ile Gln Ile Arg 
        675                 680                 685             


Lys Asn Glu Tyr Asp Leu Ile Leu Asn Ser Asp Ile Asn Ser Asn His 
    690                 695                 700                 


Tyr His Gln Trp Phe Tyr Phe Glu Val Ser Gly Met Arg Pro Gly Val 
705                 710                 715                 720 


Ala Tyr Arg Phe Asn Ile Ile Asn Cys Glu Lys Ser Asn Ser Gln Phe 
                725                 730                 735     


Asn Tyr Gly Met Gln Pro Leu Met Tyr Ser Val Gln Glu Ala Leu Asn 
            740                 745                 750         


Ala Arg Pro Trp Trp Ile Arg Met Gly Thr Asp Ile Cys Tyr Tyr Lys 
        755                 760                 765             


Asn His Phe Ser Arg Ser Ser Val Ala Ala Gly Gly Gln Lys Gly Lys 
    770                 775                 780                 


Ser Tyr Tyr Thr Ile Thr Phe Thr Val Asn Phe Pro His Lys Asp Asp 
785                 790                 795                 800 


Val Cys Tyr Phe Ala Tyr His Tyr Pro Tyr Thr Tyr Ser Thr Leu Gln 
                805                 810                 815     


Met His Leu Gln Lys Leu Glu Ser Ala His Asn Pro Gln Gln Ile Tyr 
            820                 825                 830         


Phe Arg Lys Asp Val Leu Cys Glu Thr Leu Ser Gly Asn Ser Cys Pro 
        835                 840                 845             


Leu Val Thr Ile Thr Ala Met Pro Glu Ser Asn Tyr Tyr Glu His Ile 
    850                 855                 860                 


Cys His Phe Arg Asn Arg Pro Tyr Val Phe Leu Ser Ala Arg Val His 
865                 870                 875                 880 


Pro Gly Glu Thr Asn Ala Ser Trp Val Met Lys Gly Thr Leu Glu Tyr 
                885                 890                 895     


Leu Met Ser Asn Asn Pro Thr Ala Gln Ser Leu Arg Glu Ser Tyr Ile 
            900                 905                 910         


Phe Lys Ile Val Pro Met Leu Asn Pro Asp Gly Val Ile Asn Gly Asn 
        915                 920                 925             


His Arg Cys Ser Leu Ser Gly Glu Asp Leu Asn Arg Gln Trp Gln Ser 
    930                 935                 940                 


Pro Ser Pro Asp Leu His Pro Thr Ile Tyr His Ala Lys Gly Leu Leu 
945                 950                 955                 960 


Gln Tyr Leu Ala Ala Val Lys Arg Leu Pro Leu Val Tyr Cys Asp Tyr 
                965                 970                 975     


His Gly His Ser Arg Lys Lys Asn Val Phe Met Tyr Gly Cys Ser Ile 
            980                 985                 990         


Lys Glu Thr Val Trp His Thr Asn  Asp Asn Ala Thr Ser  Cys Asp Val 
        995                 1000                 1005             


Val Glu  Asp Thr Gly Tyr Arg  Thr Leu Pro Lys Ile  Leu Ser His 
    1010                 1015                 1020             


Ile Ala  Pro Ala Phe Cys Met  Ser Ser Cys Ser Phe  Val Val Glu 
    1025                 1030                 1035             


Lys Ser  Lys Glu Ser Thr Ala  Arg Val Val Val Trp  Arg Glu Ile 
    1040                 1045                 1050             


Gly Val  Gln Arg Ser Tyr Thr  Met Glu Ser Thr Leu  Cys Gly Cys 
    1055                 1060                 1065             


Asp Gln  Gly Lys Tyr Lys Gly  Leu Gln Ile Gly Thr  Arg Glu Leu 
    1070                 1075                 1080             


Glu Glu  Met Gly Ala Lys Phe  Cys Val Gly Leu Leu  Arg Leu Lys 
    1085                 1090                 1095             


Arg Leu  Thr Ser Pro Leu Glu  Tyr Asn Leu Pro Ser  Ser Leu Leu 
    1100                 1105                 1110             


Asp Phe  Glu Asn Asp Leu Ile  Glu Ser Ser Cys Lys  Val Thr Ser 
    1115                 1120                 1125             


Pro Thr  Thr Tyr Val Leu Asp  Glu Asp Glu Pro Arg  Phe Leu Glu 
    1130                 1135                 1140             


Glu Val  Asp Tyr Ser Ala Glu  Ser Asn Asp Glu Leu  Asp Ile Glu 
    1145                 1150                 1155             


Leu Ala  Glu Asn Val Gly Asp  Tyr Glu Pro Ser Ala  Gln Glu Glu 
    1160                 1165                 1170             


Val Leu  Ser Asp Ser Glu Leu  Ser Arg Thr Tyr Leu  Pro 
    1175                 1180                 1185     


<210>  628
<211>  159
<212>  PRT
<213>  Homo Sapiens

<400>  628

Met Glu Leu Pro Ala Val Asn Leu Lys Cys Ala Ser Ser Ser Val Pro 
1               5                   10                  15      


Arg Asn His Pro His Val Ile Leu Leu Gly His Trp Leu Leu Thr Thr 
            20                  25                  30          


Cys Phe Trp Arg His Phe Ser Ala Lys Pro Arg Leu Glu Thr Ile Glu 
        35                  40                  45              


Leu Thr Cys Ala Leu Cys Lys Leu Arg Ser Ala Ala His Arg Ala Thr 
    50                  55                  60                  


Ala Gly Leu His Cys Ile Leu Arg Leu Leu Cys Leu Gly Gln Leu His 
65                  70                  75                  80  


His Pro Gly Leu Gly Arg Val Gly Cys Gly Ser Ala Gly Leu His Arg 
                85                  90                  95      


Arg His Lys His Val Ser Gly Trp Leu Ala Gly His His Leu Pro Gly 
            100                 105                 110         


His Arg Ala His Gln His Leu Leu Pro Ala Gly Gln Pro His Gly His 
        115                 120                 125             


Gly Pro Leu Trp Arg Gly His Gly His Pro Gln Leu Ala Ala Gln Ala 
    130                 135                 140                 


Ala Leu Leu Leu Leu Arg Leu Pro His Val Pro Gly Ala Arg Gly 
145                 150                 155                 


<210>  629
<211>  111
<212>  PRT
<213>  Homo Sapiens

<400>  629

Met Glu Leu Pro Ala Val Asn Leu Lys Gly Leu His Cys Ile Leu Arg 
1               5                   10                  15      


Leu Leu Cys Leu Gly Gln Leu His His Pro Gly Leu Gly Arg Val Gly 
            20                  25                  30          


Cys Gly Ser Ala Gly Leu His Arg Arg His Lys His Val Ser Gly Trp 
        35                  40                  45              


Leu Ala Gly His His Leu Pro Gly His Arg Ala His Gln His Leu Leu 
    50                  55                  60                  


Pro Ala Gly Gln Pro His Gly His Gly Pro Leu Trp Arg Gly His Gly 
65                  70                  75                  80  


His Pro Gln Leu Ala Ala Gln Ala Ala Leu Leu Leu Leu Arg Leu Pro 
                85                  90                  95      


His Val Pro Gly Ala Arg Gly Phe Pro Trp Val Phe Ser Gly Pro 
            100                 105                 110     


<210>  630
<211>  147
<212>  PRT
<213>  Homo Sapiens

<400>  630

Met Glu Leu Pro Ala Val Asn Leu Lys Val Ile Leu Leu Gly His Trp 
1               5                   10                  15      


Leu Leu Thr Thr Cys Phe Trp Arg His Phe Ser Ala Lys Pro Arg Leu 
            20                  25                  30          


Glu Thr Ile Glu Leu Thr Cys Ala Leu Cys Lys Leu Arg Ser Ala Ala 
        35                  40                  45              


His Arg Ala Thr Ala Gly Leu His Cys Ile Leu Arg Leu Leu Cys Leu 
    50                  55                  60                  


Gly Gln Leu His His Pro Gly Leu Gly Arg Val Gly Cys Gly Ser Ala 
65                  70                  75                  80  


Gly Leu His Arg Arg His Lys His Val Ser Gly Trp Leu Ala Gly His 
                85                  90                  95      


His Leu Pro Gly His Arg Ala His Gln His Leu Leu Pro Ala Gly Gln 
            100                 105                 110         


Pro His Gly His Gly Pro Leu Trp Arg Gly His Gly His Pro Gln Leu 
        115                 120                 125             


Ala Ala Gln Ala Ala Leu Leu Leu Leu Arg Leu Pro His Val Pro Gly 
    130                 135                 140                 


Ala Arg Gly 
145         


<210>  631
<211>  155
<212>  PRT
<213>  Homo Sapiens

<400>  631

Met Glu Leu Pro Ala Val Asn Leu Lys Val Ile Leu Leu Gly His Trp 
1               5                   10                  15      


Leu Leu Thr Thr Cys Phe Trp Arg His Phe Ser Ala Lys Pro Arg Leu 
            20                  25                  30          


Glu Thr Ile Glu Leu Thr Cys Ala Leu Cys Lys Leu Arg Ser Ala Ala 
        35                  40                  45              


His Arg Ala Thr Ala Gly Leu His Cys Ile Leu Arg Leu Leu Cys Leu 
    50                  55                  60                  


Gly Gln Leu His His Pro Gly Leu Gly Arg Val Gly Cys Gly Ser Ala 
65                  70                  75                  80  


Gly Leu His Arg Arg His Lys His Val Ser Gly Trp Leu Ala Gly His 
                85                  90                  95      


His Leu Pro Gly His Arg Ala His Gln His Leu Leu Pro Ala Gly Gln 
            100                 105                 110         


Pro His Gly His Gly Pro Leu Trp Arg Gly His Gly His Pro Gln Leu 
        115                 120                 125             


Ala Ala Gln Ala Ala Leu Leu Leu Leu Arg Leu Pro His Val Pro Gly 
    130                 135                 140                 


Ala Arg Gly Phe Pro Trp Val Phe Ser Gly Pro 
145                 150                 155 


<210>  632
<211>  155
<212>  PRT
<213>  Homo Sapiens

<400>  632

Met Glu Leu Pro Ala Val Asn Leu Lys Val Ile Leu Leu Gly His Trp 
1               5                   10                  15      


Leu Leu Thr Thr Cys Phe Trp Val Ala Cys Trp Pro Pro Ser Ser Trp 
            20                  25                  30          


Thr Ser Cys Thr Ser Ala Ser Ser Thr Arg Gly Ser Ala Ser Arg Thr 
        35                  40                  45              


Arg Ala Ala Leu Ala Trp Ala Trp Pro Ser Ser Ala Cys Cys Ser Ser 
    50                  55                  60                  


Arg Ser Pro Ala Ala Ser Ser Thr Thr Cys Thr Gly Ser Ala Gly Val 
65                  70                  75                  80  


Ser Ser Trp Ser Thr Leu Val Ser Leu Gly Leu Leu Arg Thr Val Val 
                85                  90                  95      


Pro Thr Arg Arg Leu Thr Gln Gln Arg Arg Pro Gln Ile Pro Leu Gln 
            100                 105                 110         


Ser Gln Arg Ala Gly Val Lys Met Pro Glu Gly Thr Glu Ala Ser His 
        115                 120                 125             


Ala Ala Pro Gly Pro Ala Pro Gly Leu Pro Arg Ala Trp Glu Val Val 
    130                 135                 140                 


Leu Gly Met Leu Leu Thr Ser Val Ser Trp Thr 
145                 150                 155 


<210>  633
<211>  159
<212>  PRT
<213>  Homo Sapiens

<400>  633

Met Glu Leu Pro Ala Val Asn Leu Lys Val Ile Leu Leu Gly His Trp 
1               5                   10                  15      


Leu Leu Thr Thr Trp Gly Cys Ile Val Phe Ser Gly Ser Tyr Ala Trp 
            20                  25                  30          


Ala Asn Phe Thr Ile Leu Ala Leu Gly Val Trp Ala Val Ala Gln Arg 
        35                  40                  45              


Asp Ser Ile Asp Ala Ile Ser Met Phe Leu Gly Gly Leu Leu Ala Thr 
    50                  55                  60                  


Ile Phe Leu Asp Ile Val His Ile Ser Ile Phe Tyr Pro Arg Val Ser 
65                  70                  75                  80  


Leu Thr Asp Thr Gly Arg Phe Gly Val Gly Met Ala Ile Leu Ser Leu 
                85                  90                  95      


Leu Leu Lys Pro Leu Ser Cys Cys Phe Val Tyr His Met Tyr Arg Glu 
            100                 105                 110         


Arg Gly Gly Glu Leu Leu Val His Thr Gly Phe Leu Gly Ser Ser Gln 
        115                 120                 125             


Asp Arg Ser Ala Tyr Gln Thr Ile Asp Ser Ala Glu Ala Pro Ala Asp 
    130                 135                 140                 


Pro Phe Ala Val Pro Glu Gly Arg Ser Gln Asp Ala Arg Gly Tyr 
145                 150                 155                 


<210>  634
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  634

Met Glu Leu Pro Ala Val Asn Leu Lys Val Ile Leu Leu Gly His Trp 
1               5                   10                  15      


Leu Leu Thr Thr Trp Gly Cys Ile Val Phe Ser Gly Ser Tyr Ala Trp 
            20                  25                  30          


Ala Asn Phe Thr Ile Leu Ala Leu Gly Val Trp Ala Val Ala Gln Arg 
        35                  40                  45              


Asp Ser Ile Asp Ala Ile Ser Met Phe Leu Gly Gly Leu Leu Ala Thr 
    50                  55                  60                  


Ile Phe Leu Asp Ile Val His Ile Ser Ile Phe Tyr Pro Arg Val Ser 
65                  70                  75                  80  


Leu Thr Asp Thr Gly Arg Phe Gly Val Gly Met Ala Ile Leu Ser Leu 
                85                  90                  95      


Leu Leu Lys Pro Leu Ser Cys Cys Phe Val Tyr His Met Tyr Arg Glu 
            100                 105                 110         


Arg Gly Gly Phe Leu Gly Ser Ser Gln Asp Arg Ser Ala Tyr Gln Thr 
        115                 120                 125             


Ile Asp Ser Ala Glu Ala Pro Ala Asp Pro Phe Ala Val Pro Glu Gly 
    130                 135                 140                 


Arg Ser Gln Asp Ala Arg Gly Tyr 
145                 150         


<210>  635
<211>  63
<212>  PRT
<213>  Homo Sapiens

<400>  635

Met Glu Leu Pro Ala Val Asn Leu Lys Val Ile Leu Leu Gly His Trp 
1               5                   10                  15      


Leu Leu Thr Thr Trp His Lys Asp Cys Thr Pro Cys Arg Ser Trp Glu 
            20                  25                  30          


Gly Asp Val Glu Val Leu Ile Arg Ala Pro Gln Gly Leu Pro His Ser 
        35                  40                  45              


Glu Ala Ser Ala Leu Gln Leu Asp Phe His Leu Tyr His Leu Phe 
    50                  55                  60              


<210>  636
<211>  508
<212>  PRT
<213>  Homo Sapiens

<400>  636

Met Glu Lys Trp Asp Gly Asn Glu Gly Thr Ser Ala Phe His Met Pro 
1               5                   10                  15      


Glu Trp Met Ile Gln Phe Ala Asp Gln Lys Gln Glu Phe Asn Lys Arg 
            20                  25                  30          


Pro Thr Lys Ile Gly Arg Arg Ser Leu Ser Arg Ser Ile Ser Gln Ser 
        35                  40                  45              


Ser Thr Asp Ser Tyr Ser Ser Ala Ala Ser Tyr Thr Asp Ser Ser Asp 
    50                  55                  60                  


Asp Glu Thr Ser Pro Arg Asp Lys Gln Gln Lys Asn Ser Lys Gly Ser 
65                  70                  75                  80  


Ser Asp Phe Cys Val Lys Asn Ile Lys Gln Ala Glu Phe Gly Arg Arg 
                85                  90                  95      


Glu Ile Glu Ile Ala Glu Gln Glu Met Pro Ala Leu Met Ala Leu Arg 
            100                 105                 110         


Lys Arg Ala Gln Gly Glu Lys Pro Leu Ala Gly Ala Lys Ile Val Gly 
        115                 120                 125             


Cys Thr His Ile Thr Ala Gln Thr Ala Val Leu Met Glu Thr Leu Gly 
    130                 135                 140                 


Ala Leu Gly Ala Gln Cys Arg Trp Ala Ala Cys Asn Ile Tyr Ser Thr 
145                 150                 155                 160 


Leu Asn Glu Val Ala Ala Ala Leu Ala Glu Ser Gly Phe Pro Val Phe 
                165                 170                 175     


Ala Trp Lys Gly Glu Ser Glu Asp Asp Phe Trp Trp Cys Ile Asp Arg 
            180                 185                 190         


Cys Val Asn Val Glu Gly Trp Gln Pro Asn Met Ile Leu Asp Asp Gly 
        195                 200                 205             


Gly Asp Leu Thr His Trp Ile Tyr Lys Lys Tyr Pro Asn Met Phe Lys 
    210                 215                 220                 


Lys Ile Lys Gly Ile Val Glu Glu Ser Val Thr Gly Val His Arg Leu 
225                 230                 235                 240 


Tyr Gln Leu Ser Lys Ala Gly Lys Leu Cys Val Pro Ala Met Asn Val 
                245                 250                 255     


Asn Asp Ser Val Thr Lys Gln Lys Phe Asp Asn Leu Tyr Cys Cys Arg 
            260                 265                 270         


Glu Ser Ile Leu Asp Gly Leu Lys Arg Thr Thr Asp Met Met Phe Gly 
        275                 280                 285             


Gly Lys Gln Val Val Val Cys Gly Tyr Gly Glu Val Gly Lys Gly Cys 
    290                 295                 300                 


Cys Ala Ala Leu Lys Ala Met Gly Ser Ile Val Tyr Val Thr Glu Ile 
305                 310                 315                 320 


Asp Pro Ile Cys Ala Leu Gln Ala Cys Met Asp Gly Phe Arg Leu Val 
                325                 330                 335     


Lys Leu Asn Glu Val Ile Arg Gln Val Asp Ile Val Ile Thr Cys Thr 
            340                 345                 350         


Gly Asn Lys Asn Val Val Thr Arg Glu His Leu Asp Arg Met Lys Asn 
        355                 360                 365             


Ser Cys Ile Val Cys Asn Met Gly His Ser Asn Thr Glu Ile Asp Val 
    370                 375                 380                 


Ala Ser Leu Arg Thr Pro Glu Leu Thr Trp Glu Arg Val Arg Ser Gln 
385                 390                 395                 400 


Val Asp His Val Ile Trp Pro Asp Gly Lys Arg Ile Val Leu Leu Ala 
                405                 410                 415     


Glu Gly Arg Leu Leu Asn Leu Ser Cys Ser Thr Val Pro Thr Phe Val 
            420                 425                 430         


Leu Ser Ile Thr Ala Thr Thr Gln Ala Leu Ala Leu Ile Glu Leu Tyr 
        435                 440                 445             


Asn Ala Pro Glu Gly Arg Tyr Lys Gln Asp Val Tyr Leu Leu Pro Lys 
    450                 455                 460                 


Lys Met Asp Glu Tyr Val Ala Ser Leu His Leu Pro Thr Phe Asp Ala 
465                 470                 475                 480 


His Leu Thr Glu Leu Thr Asp Glu Gln Ala Lys Tyr Leu Gly Leu Asn 
                485                 490                 495     


Lys Asn Gly Pro Phe Lys Pro Asn Tyr Tyr Arg Tyr 
            500                 505             


<210>  637
<211>  75
<212>  PRT
<213>  Homo Sapiens

<400>  637

Met Glu Lys Trp Asp Gly Asn Glu Gly Thr Ser Ala Phe His Met Pro 
1               5                   10                  15      


Glu Trp Met Gln Ile Gln Phe Ala Asp Gln Lys Gln Glu Phe Asn Lys 
            20                  25                  30          


Arg Pro Thr Lys Ile Gly Arg Arg Ser Leu Ser Arg Ser Ile Ser Gln 
        35                  40                  45              


Ser Ser Thr Asp Ser Tyr Ser Ser Ala Ala Ser Tyr Thr Asp Ser Ser 
    50                  55                  60                  


Asp Asp Glu Thr Ser Pro Arg Asp Lys Gln Gln 
65                  70                  75  


<210>  638
<211>  508
<212>  PRT
<213>  Homo Sapiens

<400>  638

Met Leu Gly Ser Lys Lys Lys Tyr Ile Val Asn Gly Asn Ser Gly Ile 
1               5                   10                  15      


Lys Ala Gln Ile Gln Phe Ala Asp Gln Lys Gln Glu Phe Asn Lys Arg 
            20                  25                  30          


Pro Thr Lys Ile Gly Arg Arg Ser Leu Ser Arg Ser Ile Ser Gln Ser 
        35                  40                  45              


Ser Thr Asp Ser Tyr Ser Ser Ala Ala Ser Tyr Thr Asp Ser Ser Asp 
    50                  55                  60                  


Asp Glu Thr Ser Pro Arg Asp Lys Gln Gln Lys Asn Ser Lys Gly Ser 
65                  70                  75                  80  


Ser Asp Phe Cys Val Lys Asn Ile Lys Gln Ala Glu Phe Gly Arg Arg 
                85                  90                  95      


Glu Ile Glu Ile Ala Glu Gln Glu Met Pro Ala Leu Met Ala Leu Arg 
            100                 105                 110         


Lys Arg Ala Gln Gly Glu Lys Pro Leu Ala Gly Ala Lys Ile Val Gly 
        115                 120                 125             


Cys Thr His Ile Thr Ala Gln Thr Ala Val Leu Met Glu Thr Leu Gly 
    130                 135                 140                 


Ala Leu Gly Ala Gln Cys Arg Trp Ala Ala Cys Asn Ile Tyr Ser Thr 
145                 150                 155                 160 


Leu Asn Glu Val Ala Ala Ala Leu Ala Glu Ser Gly Phe Pro Val Phe 
                165                 170                 175     


Ala Trp Lys Gly Glu Ser Glu Asp Asp Phe Trp Trp Cys Ile Asp Arg 
            180                 185                 190         


Cys Val Asn Val Glu Gly Trp Gln Pro Asn Met Ile Leu Asp Asp Gly 
        195                 200                 205             


Gly Asp Leu Thr His Trp Ile Tyr Lys Lys Tyr Pro Asn Met Phe Lys 
    210                 215                 220                 


Lys Ile Lys Gly Ile Val Glu Glu Ser Val Thr Gly Val His Arg Leu 
225                 230                 235                 240 


Tyr Gln Leu Ser Lys Ala Gly Lys Leu Cys Val Pro Ala Met Asn Val 
                245                 250                 255     


Asn Asp Ser Val Thr Lys Gln Lys Phe Asp Asn Leu Tyr Cys Cys Arg 
            260                 265                 270         


Glu Ser Ile Leu Asp Gly Leu Lys Arg Thr Thr Asp Met Met Phe Gly 
        275                 280                 285             


Gly Lys Gln Val Val Val Cys Gly Tyr Gly Glu Val Gly Lys Gly Cys 
    290                 295                 300                 


Cys Ala Ala Leu Lys Ala Met Gly Ser Ile Val Tyr Val Thr Glu Ile 
305                 310                 315                 320 


Asp Pro Ile Cys Ala Leu Gln Ala Cys Met Asp Gly Phe Arg Leu Val 
                325                 330                 335     


Lys Leu Asn Glu Val Ile Arg Gln Val Asp Ile Val Ile Thr Cys Thr 
            340                 345                 350         


Gly Asn Lys Asn Val Val Thr Arg Glu His Leu Asp Arg Met Lys Asn 
        355                 360                 365             


Ser Cys Ile Val Cys Asn Met Gly His Ser Asn Thr Glu Ile Asp Val 
    370                 375                 380                 


Ala Ser Leu Arg Thr Pro Glu Leu Thr Trp Glu Arg Val Arg Ser Gln 
385                 390                 395                 400 


Val Asp His Val Ile Trp Pro Asp Gly Lys Arg Ile Val Leu Leu Ala 
                405                 410                 415     


Glu Gly Arg Leu Leu Asn Leu Ser Cys Ser Thr Val Pro Thr Phe Val 
            420                 425                 430         


Leu Ser Ile Thr Ala Thr Thr Gln Ala Leu Ala Leu Ile Glu Leu Tyr 
        435                 440                 445             


Asn Ala Pro Glu Gly Arg Tyr Lys Gln Asp Val Tyr Leu Leu Pro Lys 
    450                 455                 460                 


Lys Met Asp Glu Tyr Val Ala Ser Leu His Leu Pro Thr Phe Asp Ala 
465                 470                 475                 480 


His Leu Thr Glu Leu Thr Asp Glu Gln Ala Lys Tyr Leu Gly Leu Asn 
                485                 490                 495     


Lys Asn Gly Pro Phe Lys Pro Asn Tyr Tyr Arg Tyr 
            500                 505             


<210>  639
<211>  183
<212>  PRT
<213>  Homo Sapiens

<400>  639

Met Leu Gly Ser Lys Lys Lys Tyr Ile Val Asn Gly Asn Ser Gly Ile 
1               5                   10                  15      


Lys Ala Gln Gln Ile Gln Phe Ala Asp Gln Lys Gln Glu Phe Asn Lys 
            20                  25                  30          


Arg Pro Thr Lys Ile Gly Arg Arg Ser Leu Ser Arg Ser Ile Ser Gln 
        35                  40                  45              


Ser Ser Thr Asp Ser Tyr Ser Ser Ala Ala Ser Tyr Thr Asp Ser Ser 
    50                  55                  60                  


Asp Asp Glu Thr Ser Pro Arg Asp Lys Gln Gln Lys Asn Ser Lys Gly 
65                  70                  75                  80  


Ser Ser Asp Phe Cys Val Lys Asn Ile Lys Gln Ala Glu Phe Gly Arg 
                85                  90                  95      


Arg Glu Ile Glu Ile Ala Glu Gln Glu Met Pro Ala Leu Met Ala Leu 
            100                 105                 110         


Arg Lys Arg Ala Gln Gly Glu Lys Pro Leu Ala Gly Ala Lys Ile Val 
        115                 120                 125             


Gly Cys Thr His Ile Thr Ala Gln Thr Ala Val Leu Met Glu Thr Leu 
    130                 135                 140                 


Gly Ala Leu Gly Ala Gln Cys Arg Trp Ala Ala Cys Asn Ile Tyr Ser 
145                 150                 155                 160 


Thr Leu Asn Glu Val Ala Ala Ala Leu Ala Glu Ser Gly Phe Pro Val 
                165                 170                 175     


Phe Ala Trp Lys Gly Glu Ser 
            180             


<210>  640
<211>  610
<212>  PRT
<213>  Homo Sapiens

<400>  640

Met Ser Val Gln Val Val Ser Ala Ala Ala Ala Ala Lys Val Pro Glu 
1               5                   10                  15      


Val Glu Leu Lys Asp Leu Ser Pro Ser Glu Ala Glu Ser Gln Leu Gly 
            20                  25                  30          


Leu Ser Thr Ala Ala Val Gly Ala Met Ala Pro Pro Ala Gly Gly Gly 
        35                  40                  45              


Asp Pro Glu Ala Pro Ala Pro Ala Ala Glu Arg Pro Pro Val Pro Gly 
    50                  55                  60                  


Pro Gly Ser Gly Pro Ala Ala Ala Leu Ser Pro Ala Ala Gly Lys Val 
65                  70                  75                  80  


Pro Gln Ala Ser Ala Met Lys Arg Ser Asp Pro His His Gln His Gln 
                85                  90                  95      


Arg His Arg Asp Gly Gly Glu Ala Leu Val Ser Pro Asp Gly Thr Val 
            100                 105                 110         


Thr Glu Ala Pro Arg Thr Val Lys Lys Ile Gln Phe Ala Asp Gln Lys 
        115                 120                 125             


Gln Glu Phe Asn Lys Arg Pro Thr Lys Ile Gly Arg Arg Ser Leu Ser 
    130                 135                 140                 


Arg Ser Ile Ser Gln Ser Ser Thr Asp Ser Tyr Ser Ser Ala Ala Ser 
145                 150                 155                 160 


Tyr Thr Asp Ser Ser Asp Asp Glu Thr Ser Pro Arg Asp Lys Gln Gln 
                165                 170                 175     


Lys Asn Ser Lys Gly Ser Ser Asp Phe Cys Val Lys Asn Ile Lys Gln 
            180                 185                 190         


Ala Glu Phe Gly Arg Arg Glu Ile Glu Ile Ala Glu Gln Glu Met Pro 
        195                 200                 205             


Ala Leu Met Ala Leu Arg Lys Arg Ala Gln Gly Glu Lys Pro Leu Ala 
    210                 215                 220                 


Gly Ala Lys Ile Val Gly Cys Thr His Ile Thr Ala Gln Thr Ala Val 
225                 230                 235                 240 


Leu Met Glu Thr Leu Gly Ala Leu Gly Ala Gln Cys Arg Trp Ala Ala 
                245                 250                 255     


Cys Asn Ile Tyr Ser Thr Leu Asn Glu Val Ala Ala Ala Leu Ala Glu 
            260                 265                 270         


Ser Gly Phe Pro Val Phe Ala Trp Lys Gly Glu Ser Glu Asp Asp Phe 
        275                 280                 285             


Trp Trp Cys Ile Asp Arg Cys Val Asn Val Glu Gly Trp Gln Pro Asn 
    290                 295                 300                 


Met Ile Leu Asp Asp Gly Gly Asp Leu Thr His Trp Ile Tyr Lys Lys 
305                 310                 315                 320 


Tyr Pro Asn Met Phe Lys Lys Ile Lys Gly Ile Val Glu Glu Ser Val 
                325                 330                 335     


Thr Gly Val His Arg Leu Tyr Gln Leu Ser Lys Ala Gly Lys Leu Cys 
            340                 345                 350         


Val Pro Ala Met Asn Val Asn Asp Ser Val Thr Lys Gln Lys Phe Asp 
        355                 360                 365             


Asn Leu Tyr Cys Cys Arg Glu Ser Ile Leu Asp Gly Leu Lys Arg Thr 
    370                 375                 380                 


Thr Asp Met Met Phe Gly Gly Lys Gln Val Val Val Cys Gly Tyr Gly 
385                 390                 395                 400 


Glu Val Gly Lys Gly Cys Cys Ala Ala Leu Lys Ala Met Gly Ser Ile 
                405                 410                 415     


Val Tyr Val Thr Glu Ile Asp Pro Ile Cys Ala Leu Gln Ala Cys Met 
            420                 425                 430         


Asp Gly Phe Arg Leu Val Lys Leu Asn Glu Val Ile Arg Gln Val Asp 
        435                 440                 445             


Ile Val Ile Thr Cys Thr Gly Asn Lys Asn Val Val Thr Arg Glu His 
    450                 455                 460                 


Leu Asp Arg Met Lys Asn Ser Cys Ile Val Cys Asn Met Gly His Ser 
465                 470                 475                 480 


Asn Thr Glu Ile Asp Val Ala Ser Leu Arg Thr Pro Glu Leu Thr Trp 
                485                 490                 495     


Glu Arg Val Arg Ser Gln Val Asp His Val Ile Trp Pro Asp Gly Lys 
            500                 505                 510         


Arg Ile Val Leu Leu Ala Glu Gly Arg Leu Leu Asn Leu Ser Cys Ser 
        515                 520                 525             


Thr Val Pro Thr Phe Val Leu Ser Ile Thr Ala Thr Thr Gln Ala Leu 
    530                 535                 540                 


Ala Leu Ile Glu Leu Tyr Asn Ala Pro Glu Gly Arg Tyr Lys Gln Asp 
545                 550                 555                 560 


Val Tyr Leu Leu Pro Lys Lys Met Asp Glu Tyr Val Ala Ser Leu His 
                565                 570                 575     


Leu Pro Thr Phe Asp Ala His Leu Thr Glu Leu Thr Asp Glu Gln Ala 
            580                 585                 590         


Lys Tyr Leu Gly Leu Asn Lys Asn Gly Pro Phe Lys Pro Asn Tyr Tyr 
        595                 600                 605             


Arg Tyr 
    610 


<210>  641
<211>  611
<212>  PRT
<213>  Homo Sapiens

<400>  641

Met Ser Val Gln Val Val Ser Ala Ala Ala Ala Ala Lys Val Pro Glu 
1               5                   10                  15      


Val Glu Leu Lys Asp Leu Ser Pro Ser Glu Ala Glu Ser Gln Leu Gly 
            20                  25                  30          


Leu Ser Thr Ala Ala Val Gly Ala Met Ala Pro Pro Ala Gly Gly Gly 
        35                  40                  45              


Asp Pro Glu Ala Pro Ala Pro Ala Ala Glu Arg Pro Pro Val Pro Gly 
    50                  55                  60                  


Pro Gly Ser Gly Pro Ala Ala Ala Leu Ser Pro Ala Ala Gly Lys Val 
65                  70                  75                  80  


Pro Gln Ala Ser Ala Met Lys Arg Ser Asp Pro His His Gln His Gln 
                85                  90                  95      


Arg His Arg Asp Gly Gly Glu Ala Leu Val Ser Pro Asp Gly Thr Val 
            100                 105                 110         


Thr Glu Ala Pro Arg Thr Val Lys Lys Gln Ile Gln Phe Ala Asp Gln 
        115                 120                 125             


Lys Gln Glu Phe Asn Lys Arg Pro Thr Lys Ile Gly Arg Arg Ser Leu 
    130                 135                 140                 


Ser Arg Ser Ile Ser Gln Ser Ser Thr Asp Ser Tyr Ser Ser Ala Ala 
145                 150                 155                 160 


Ser Tyr Thr Asp Ser Ser Asp Asp Glu Thr Ser Pro Arg Asp Lys Gln 
                165                 170                 175     


Gln Lys Asn Ser Lys Gly Ser Ser Asp Phe Cys Val Lys Asn Ile Lys 
            180                 185                 190         


Gln Ala Glu Phe Gly Arg Arg Glu Ile Glu Ile Ala Glu Gln Glu Met 
        195                 200                 205             


Pro Ala Leu Met Ala Leu Arg Lys Arg Ala Gln Gly Glu Lys Pro Leu 
    210                 215                 220                 


Ala Gly Ala Lys Ile Val Gly Cys Thr His Ile Thr Ala Gln Thr Ala 
225                 230                 235                 240 


Val Leu Met Glu Thr Leu Gly Ala Leu Gly Ala Gln Cys Arg Trp Ala 
                245                 250                 255     


Ala Cys Asn Ile Tyr Ser Thr Leu Asn Glu Val Ala Ala Ala Leu Ala 
            260                 265                 270         


Glu Ser Gly Phe Pro Val Phe Ala Trp Lys Gly Glu Ser Glu Asp Asp 
        275                 280                 285             


Phe Trp Trp Cys Ile Asp Arg Cys Val Asn Val Glu Gly Trp Gln Pro 
    290                 295                 300                 


Asn Met Ile Leu Asp Asp Gly Gly Asp Leu Thr His Trp Ile Tyr Lys 
305                 310                 315                 320 


Lys Tyr Pro Asn Met Phe Lys Lys Ile Lys Gly Ile Val Glu Glu Ser 
                325                 330                 335     


Val Thr Gly Val His Arg Leu Tyr Gln Leu Ser Lys Ala Gly Lys Leu 
            340                 345                 350         


Cys Val Pro Ala Met Asn Val Asn Asp Ser Val Thr Lys Gln Lys Phe 
        355                 360                 365             


Asp Asn Leu Tyr Cys Cys Arg Glu Ser Ile Leu Asp Gly Leu Lys Arg 
    370                 375                 380                 


Thr Thr Asp Met Met Phe Gly Gly Lys Gln Val Val Val Cys Gly Tyr 
385                 390                 395                 400 


Gly Glu Val Gly Lys Gly Cys Cys Ala Ala Leu Lys Ala Met Gly Ser 
                405                 410                 415     


Ile Val Tyr Val Thr Glu Ile Asp Pro Ile Cys Ala Leu Gln Ala Cys 
            420                 425                 430         


Met Asp Gly Phe Arg Leu Val Lys Leu Asn Glu Val Ile Arg Gln Val 
        435                 440                 445             


Asp Ile Val Ile Thr Cys Thr Gly Asn Lys Asn Val Val Thr Arg Glu 
    450                 455                 460                 


His Leu Asp Arg Met Lys Asn Ser Cys Ile Val Cys Asn Met Gly His 
465                 470                 475                 480 


Ser Asn Thr Glu Ile Asp Val Ala Ser Leu Arg Thr Pro Glu Leu Thr 
                485                 490                 495     


Trp Glu Arg Val Arg Ser Gln Val Asp His Val Ile Trp Pro Asp Gly 
            500                 505                 510         


Lys Arg Ile Val Leu Leu Ala Glu Gly Arg Leu Leu Asn Leu Ser Cys 
        515                 520                 525             


Ser Thr Val Pro Thr Phe Val Leu Ser Ile Thr Ala Thr Thr Gln Ala 
    530                 535                 540                 


Leu Ala Leu Ile Glu Leu Tyr Asn Ala Pro Glu Gly Arg Tyr Lys Gln 
545                 550                 555                 560 


Asp Val Tyr Leu Leu Pro Lys Lys Met Asp Glu Tyr Val Ala Ser Leu 
                565                 570                 575     


His Leu Pro Thr Phe Asp Ala His Leu Thr Glu Leu Thr Asp Glu Gln 
            580                 585                 590         


Ala Lys Tyr Leu Gly Leu Asn Lys Asn Gly Pro Phe Lys Pro Asn Tyr 
        595                 600                 605             


Tyr Arg Tyr 
    610     


<210>  642
<211>  518
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  642

Xaa Arg Lys Trp Ser Arg Gln Phe Leu Leu Ser Phe Trp Cys Thr Val 
1               5                   10                  15      


Cys Ser Ala His Gln Gly Thr Ile Phe Leu Ser Leu Lys Ile Gln Phe 
            20                  25                  30          


Ala Asp Gln Lys Gln Glu Phe Asn Lys Arg Pro Thr Lys Ile Gly Arg 
        35                  40                  45              


Arg Ser Leu Ser Arg Ser Ile Ser Gln Ser Ser Thr Asp Ser Tyr Ser 
    50                  55                  60                  


Ser Ala Ala Ser Tyr Thr Asp Ser Ser Asp Asp Glu Thr Ser Pro Arg 
65                  70                  75                  80  


Asp Lys Gln Gln Lys Asn Ser Lys Gly Ser Ser Asp Phe Cys Val Lys 
                85                  90                  95      


Asn Ile Lys Gln Ala Glu Phe Gly Arg Arg Glu Ile Glu Ile Ala Glu 
            100                 105                 110         


Gln Glu Met Pro Ala Leu Met Ala Leu Arg Lys Arg Ala Gln Gly Glu 
        115                 120                 125             


Lys Pro Leu Ala Gly Ala Lys Ile Val Gly Cys Thr His Ile Thr Ala 
    130                 135                 140                 


Gln Thr Ala Val Leu Met Glu Thr Leu Gly Ala Leu Gly Ala Gln Cys 
145                 150                 155                 160 


Arg Trp Ala Ala Cys Asn Ile Tyr Ser Thr Leu Asn Glu Val Ala Ala 
                165                 170                 175     


Ala Leu Ala Glu Ser Gly Phe Pro Val Phe Ala Trp Lys Gly Glu Ser 
            180                 185                 190         


Glu Asp Asp Phe Trp Trp Cys Ile Asp Arg Cys Val Asn Val Glu Gly 
        195                 200                 205             


Trp Gln Pro Asn Met Ile Leu Asp Asp Gly Gly Asp Leu Thr His Trp 
    210                 215                 220                 


Ile Tyr Lys Lys Tyr Pro Asn Met Phe Lys Lys Ile Lys Gly Ile Val 
225                 230                 235                 240 


Glu Glu Ser Val Thr Gly Val His Arg Leu Tyr Gln Leu Ser Lys Ala 
                245                 250                 255     


Gly Lys Leu Cys Val Pro Ala Met Asn Val Asn Asp Ser Val Thr Lys 
            260                 265                 270         


Gln Lys Phe Asp Asn Leu Tyr Cys Cys Arg Glu Ser Ile Leu Asp Gly 
        275                 280                 285             


Leu Lys Arg Thr Thr Asp Met Met Phe Gly Gly Lys Gln Val Val Val 
    290                 295                 300                 


Cys Gly Tyr Gly Glu Val Gly Lys Gly Cys Cys Ala Ala Leu Lys Ala 
305                 310                 315                 320 


Met Gly Ser Ile Val Tyr Val Thr Glu Ile Asp Pro Ile Cys Ala Leu 
                325                 330                 335     


Gln Ala Cys Met Asp Gly Phe Arg Leu Val Lys Leu Asn Glu Val Ile 
            340                 345                 350         


Arg Gln Val Asp Ile Val Ile Thr Cys Thr Gly Asn Lys Asn Val Val 
        355                 360                 365             


Thr Arg Glu His Leu Asp Arg Met Lys Asn Ser Cys Ile Val Cys Asn 
    370                 375                 380                 


Met Gly His Ser Asn Thr Glu Ile Asp Val Ala Ser Leu Arg Thr Pro 
385                 390                 395                 400 


Glu Leu Thr Trp Glu Arg Val Arg Ser Gln Val Asp His Val Ile Trp 
                405                 410                 415     


Pro Asp Gly Lys Arg Ile Val Leu Leu Ala Glu Gly Arg Leu Leu Asn 
            420                 425                 430         


Leu Ser Cys Ser Thr Val Pro Thr Phe Val Leu Ser Ile Thr Ala Thr 
        435                 440                 445             


Thr Gln Ala Leu Ala Leu Ile Glu Leu Tyr Asn Ala Pro Glu Gly Arg 
    450                 455                 460                 


Tyr Lys Gln Asp Val Tyr Leu Leu Pro Lys Lys Met Asp Glu Tyr Val 
465                 470                 475                 480 


Ala Ser Leu His Leu Pro Thr Phe Asp Ala His Leu Thr Glu Leu Thr 
                485                 490                 495     


Asp Glu Gln Ala Lys Tyr Leu Gly Leu Asn Lys Asn Gly Pro Phe Lys 
            500                 505                 510         


Pro Asn Tyr Tyr Arg Tyr 
        515             


<210>  643
<211>  368
<212>  PRT
<213>  Homo Sapiens

<400>  643

Met Lys Ser Leu Val Leu Leu Leu Cys Leu Ala Gln Leu Trp Gly Cys 
1               5                   10                  15      


His Ser Ala Pro His Gly Pro Gly Leu Ile Tyr Arg Gln Pro Asn Cys 
            20                  25                  30          


Asp Asp Pro Glu Thr Glu Glu Ala Ala Leu Val Ala Ile Asp Tyr Ile 
        35                  40                  45              


Asn Gln Asn Leu Pro Trp Gly Tyr Lys His Thr Leu Asn Gln Ile Asp 
    50                  55                  60                  


Glu Val Lys Val Trp Pro Gln Gln Pro Ser Gly Glu Leu Phe Glu Ile 
65                  70                  75                  80  


Glu Ile Asp Thr Leu Glu Thr Thr Cys His Val Leu Asp Pro Thr Pro 
                85                  90                  95      


Val Ala Arg Cys Ser Val Arg Gln Leu Lys Glu His Ala Val Glu Gly 
            100                 105                 110         


Asp Cys Asp Phe Gln Leu Leu Lys Leu Asp Gly Lys Phe Ser Val Val 
        115                 120                 125             


Tyr Ala Lys Cys Asp Ser Ser Pro Ala Asp Ser Ala Glu Asp Val Arg 
    130                 135                 140                 


Lys Val Cys Gln Asp Cys Pro Leu Leu Ala Pro Leu Asn Asp Thr Arg 
145                 150                 155                 160 


Val Val His Ala Ala Lys Ala Ala Leu Ala Ala Phe Asn Ala Gln Asn 
                165                 170                 175     


Asn Gly Ser Asn Phe Gln Leu Glu Glu Ile Ser Arg Ala Gln Leu Val 
            180                 185                 190         


Pro Leu Pro Pro Ser Thr Tyr Val Glu Phe Thr Val Ser Gly Thr Asp 
        195                 200                 205             


Cys Val Ala Lys Glu Ala Thr Glu Ala Ala Lys Cys Asn Leu Leu Ala 
    210                 215                 220                 


Glu Lys Gln Tyr Gly Phe Cys Lys Ala Thr Leu Ser Glu Lys Leu Gly 
225                 230                 235                 240 


Gly Ala Glu Val Ala Val Thr Cys Met Val Phe Gln Thr Gln Pro Val 
                245                 250                 255     


Ser Ser Gln Pro Gln Pro Glu Gly Ala Asn Glu Ala Val Pro Thr Pro 
            260                 265                 270         


Val Val Asp Pro Asp Ala Pro Pro Ser Pro Pro Leu Gly Ala Pro Gly 
        275                 280                 285             


Leu Pro Pro Ala Gly Ser Pro Pro Asp Ser His Val Leu Leu Ala Ala 
    290                 295                 300                 


Pro Pro Gly His Gln Leu His Arg Ala His Tyr Asp Leu Arg His Thr 
305                 310                 315                 320 


Phe Met Gly Val Val Ser Leu Gly Ser Pro Ser Gly Glu Val Ser His 
                325                 330                 335     


Pro Arg Lys Thr Arg Thr Val Val Gln Pro Ser Val Gly Ala Ala Ala 
            340                 345                 350         


Gly Pro Val Val Pro Pro Cys Pro Gly Arg Ile Arg His Phe Lys Val 
        355                 360                 365             


<210>  644
<211>  367
<212>  PRT
<213>  Homo Sapiens

<400>  644

Met Lys Ser Leu Val Leu Leu Leu Cys Leu Ala Gln Leu Trp Gly Cys 
1               5                   10                  15      


His Ser Ala Pro His Gly Pro Gly Leu Ile Tyr Arg Gln Pro Asn Cys 
            20                  25                  30          


Asp Asp Pro Glu Thr Glu Glu Ala Ala Leu Val Ala Ile Asp Tyr Ile 
        35                  40                  45              


Asn Gln Asn Leu Pro Trp Gly Tyr Lys His Thr Leu Asn Gln Ile Asp 
    50                  55                  60                  


Glu Val Lys Val Trp Pro Gln Gln Pro Ser Gly Glu Leu Phe Glu Ile 
65                  70                  75                  80  


Glu Ile Asp Thr Leu Glu Thr Thr Cys His Val Leu Asp Pro Thr Pro 
                85                  90                  95      


Val Ala Arg Cys Ser Val Arg Gln Leu Lys Glu His Ala Val Glu Gly 
            100                 105                 110         


Asp Cys Asp Phe Gln Leu Leu Lys Leu Asp Gly Lys Phe Ser Val Val 
        115                 120                 125             


Tyr Ala Lys Cys Asp Ser Ser Pro Asp Ser Ala Glu Asp Val Arg Lys 
    130                 135                 140                 


Val Cys Gln Asp Cys Pro Leu Leu Ala Pro Leu Asn Asp Thr Arg Val 
145                 150                 155                 160 


Val His Ala Ala Lys Ala Ala Leu Ala Ala Phe Asn Ala Gln Asn Asn 
                165                 170                 175     


Gly Ser Asn Phe Gln Leu Glu Glu Ile Ser Arg Ala Gln Leu Val Pro 
            180                 185                 190         


Leu Pro Pro Ser Thr Tyr Val Glu Phe Thr Val Ser Gly Thr Asp Cys 
        195                 200                 205             


Val Ala Lys Glu Ala Thr Glu Ala Ala Lys Cys Asn Leu Leu Ala Glu 
    210                 215                 220                 


Lys Gln Tyr Gly Phe Cys Lys Ala Thr Leu Ser Glu Lys Leu Gly Gly 
225                 230                 235                 240 


Ala Glu Val Ala Val Thr Cys Met Val Phe Gln Thr Gln Pro Val Ser 
                245                 250                 255     


Ser Gln Pro Gln Pro Glu Gly Ala Asn Glu Ala Val Pro Thr Pro Val 
            260                 265                 270         


Val Asp Pro Asp Ala Pro Pro Ser Pro Pro Leu Gly Ala Pro Gly Leu 
        275                 280                 285             


Pro Pro Ala Gly Ser Pro Pro Asp Ser His Val Leu Leu Ala Ala Pro 
    290                 295                 300                 


Pro Gly His Gln Leu His Arg Ala His Tyr Asp Leu Arg His Thr Phe 
305                 310                 315                 320 


Met Gly Val Val Ser Leu Gly Ser Pro Ser Gly Glu Val Ser His Pro 
                325                 330                 335     


Arg Lys Thr Arg Thr Val Val Gln Pro Ser Val Gly Ala Ala Ala Gly 
            340                 345                 350         


Pro Val Val Pro Pro Cys Pro Gly Arg Ile Arg His Phe Lys Val 
        355                 360                 365         


<210>  645
<211>  47
<212>  PRT
<213>  Homo Sapiens

<400>  645

Met Ala Leu Val Pro Cys Gln Val Leu Arg Met Ala Ile Leu Leu Ser 
1               5                   10                  15      


Tyr Cys Ser Ile Leu Cys Asn Tyr Lys Ala Ile Glu Met Pro Ser His 
            20                  25                  30          


Gln Thr Tyr Gly Gly Ser Trp Lys Phe Leu Thr Phe Ile Asp Leu 
        35                  40                  45          


<210>  646
<211>  124
<212>  PRT
<213>  Homo Sapiens

<400>  646

Met Ala Leu Val Pro Cys Gln Val Leu Arg Met Ala Ile Leu Leu Ser 
1               5                   10                  15      


Tyr Cys Ser Ile Leu Cys Asn Tyr Lys Ala Ile Glu Met Pro Ser His 
            20                  25                  30          


Gln Thr Tyr Gly Gly Ser Trp Lys Phe Leu Thr Phe Ile Asp Leu Phe 
        35                  40                  45              


Val Val Ala Val Phe Trp Ile Ile Tyr Ala Tyr Asp Arg Glu Met Ile 
    50                  55                  60                  


Tyr Pro Lys Leu Leu Asp Asn Phe Ile Pro Gly Trp Leu Asn His Gly 
65                  70                  75                  80  


Met His Thr Thr Val Leu Pro Phe Ile Leu Ile Glu Met Arg Thr Ser 
                85                  90                  95      


His His Gln Tyr Pro Ser Arg Ser Ser Gly Leu Thr Ala Ile Cys Thr 
            100                 105                 110         


Phe Ser Val Gly Tyr Ile Leu Trp Val Cys Trp Val 
        115                 120                 


<210>  647
<211>  137
<212>  PRT
<213>  Homo Sapiens

<400>  647

Met Ala Leu Val Pro Cys Gln Val Leu Arg Met Ala Ile Leu Leu Ser 
1               5                   10                  15      


Tyr Cys Ser Ile Leu Cys Asn Tyr Lys Ala Ile Glu Met Pro Ser His 
            20                  25                  30          


Gln Thr Tyr Gly Gly Ser Trp Lys Phe Leu Thr Phe Ile Asp Leu Val 
        35                  40                  45              


Ile Gln Ala Val Phe Phe Gly Ile Cys Val Leu Thr Asp Leu Ser Ser 
    50                  55                  60                  


Leu Leu Thr Arg Gly Ser Gly Asn Gln Glu Gln Glu Arg Gln Leu Lys 
65                  70                  75                  80  


Lys Leu Ile Ser Leu Arg Asp Trp Met Leu Ala Val Leu Ala Phe Pro 
                85                  90                  95      


Val Gly Val Phe Val Val Ala Val Phe Trp Ile Ile Tyr Ala Tyr Asp 
            100                 105                 110         


Arg Glu Met Ile Tyr Pro Lys Leu Leu Asp Asn Phe Ile Pro Gly Trp 
        115                 120                 125             


Leu Asn His Gly Met His Phe Lys Ala 
    130                 135         


<210>  648
<211>  245
<212>  PRT
<213>  Homo Sapiens

<400>  648

Met Ala Leu Val Pro Cys Gln Val Leu Arg Met Ala Ile Leu Leu Ser 
1               5                   10                  15      


Tyr Cys Ser Ile Leu Cys Asn Tyr Lys Ala Ile Glu Met Pro Ser His 
            20                  25                  30          


Gln Thr Tyr Gly Gly Ser Trp Lys Phe Leu Thr Phe Ile Asp Leu Val 
        35                  40                  45              


Ile Gln Ala Val Phe Phe Gly Ile Cys Val Leu Thr Asp Leu Ser Ser 
    50                  55                  60                  


Leu Leu Thr Arg Gly Ser Gly Asn Gln Glu Gln Glu Arg Gln Leu Lys 
65                  70                  75                  80  


Lys Leu Ile Ser Leu Arg Asp Trp Met Leu Ala Val Leu Ala Phe Pro 
                85                  90                  95      


Val Gly Val Phe Val Val Ala Val Phe Trp Ile Ile Tyr Ala Tyr Asp 
            100                 105                 110         


Arg Glu Met Ile Tyr Pro Lys Leu Leu Asp Asn Phe Ile Pro Gly Trp 
        115                 120                 125             


Leu Asn His Gly Met His Thr Thr Val Leu Pro Phe Ile Leu Ile Glu 
    130                 135                 140                 


Met Arg Thr Ser His His Gln Tyr Pro Ser Arg Ser Ser Gly Leu Thr 
145                 150                 155                 160 


Ala Ile Cys Thr Phe Ser Val Gly Tyr Ile Leu Trp Val Cys Trp Val 
                165                 170                 175     


His His Val Thr Gly Met Trp Val Tyr Pro Phe Leu Glu His Ile Gly 
            180                 185                 190         


Pro Gly Ala Arg Ile Ile Phe Phe Gly Ser Thr Thr Ile Leu Met Asn 
        195                 200                 205             


Phe Leu Tyr Leu Leu Gly Glu Val Leu Asn Asn Tyr Ile Trp Asp Thr 
    210                 215                 220                 


Gln Lys Lys Pro Pro Ser Trp Gln Asp Met Lys Ile Lys Phe Met Tyr 
225                 230                 235                 240 


Leu Gly Pro Ser Ser 
                245 


<210>  649
<211>  238
<212>  PRT
<213>  Homo Sapiens

<400>  649

Met Ala Leu Val Pro Cys Gln Val Leu Arg Met Ala Ile Leu Leu Ser 
1               5                   10                  15      


Tyr Cys Ser Ile Leu Cys Asn Tyr Lys Ala Ile Glu Met Pro Ser His 
            20                  25                  30          


Gln Thr Tyr Gly Gly Ser Trp Lys Phe Leu Thr Phe Ile Asp Leu Val 
        35                  40                  45              


Ile Gln Ala Val Phe Phe Gly Ile Cys Val Leu Thr Asp Leu Ser Ser 
    50                  55                  60                  


Leu Leu Thr Arg Gly Ser Gly Asn Gln Glu Gln Glu Arg Gln Leu Lys 
65                  70                  75                  80  


Lys Leu Ile Ser Leu Arg Asp Trp Met Leu Ala Val Leu Ala Phe Pro 
                85                  90                  95      


Val Gly Val Phe Val Val Ala Val Phe Trp Ile Ile Tyr Ala Tyr Asp 
            100                 105                 110         


Arg Glu Met Ile Tyr Pro Lys Leu Leu Asp Asn Phe Ile Pro Gly Trp 
        115                 120                 125             


Leu Asn His Gly Met His Thr Thr Val Leu Pro Phe Ile Leu Ile Glu 
    130                 135                 140                 


Met Arg Thr Ser His His Gln Tyr Pro Ser Arg Ser Ser Gly Leu Thr 
145                 150                 155                 160 


Ala Ile Cys Thr Phe Ser Val Gly Tyr Ile Leu Trp Val Cys Trp Val 
                165                 170                 175     


His His Val Thr Gly Met Trp Val Tyr Pro Phe Leu Glu His Ile Gly 
            180                 185                 190         


Pro Gly Ala Arg Ile Ile Phe Phe Gly Ser Thr Thr Ile Leu Met Asn 
        195                 200                 205             


Phe Leu Tyr Leu Leu Gly Glu Val Leu Asn Asn Tyr Ile Trp Asp Thr 
    210                 215                 220                 


Gln Lys Ser Met Glu Glu Glu Lys Glu Lys Pro Lys Leu Glu 
225                 230                 235             


<210>  650
<211>  231
<212>  PRT
<213>  Homo Sapiens

<400>  650

Met Ala Leu Val Pro Cys Gln Val Leu Arg Met Ala Ile Leu Leu Ser 
1               5                   10                  15      


Tyr Cys Ser Ile Leu Cys Asn Tyr Lys Ala Ile Glu Met Pro Ser His 
            20                  25                  30          


Gln Thr Tyr Gly Gly Ser Trp Lys Phe Leu Thr Phe Ile Asp Leu Val 
        35                  40                  45              


Ile Gln Ala Val Phe Phe Gly Ile Cys Val Leu Thr Asp Leu Ser Ser 
    50                  55                  60                  


Leu Leu Thr Arg Gly Ser Gly Asn Gln Glu Gln Glu Arg Gln Leu Lys 
65                  70                  75                  80  


Lys Leu Ile Ser Leu Arg Asp Trp Met Leu Ala Val Leu Ala Phe Pro 
                85                  90                  95      


Val Gly Val Phe Val Val Ala Val Phe Trp Ile Ile Tyr Ala Tyr Asp 
            100                 105                 110         


Arg Glu Met Ile Tyr Pro Lys Leu Leu Asp Asn Phe Ile Pro Gly Trp 
        115                 120                 125             


Leu Asn His Gly Met His Thr Thr Val Leu Pro Phe Ile Leu Ile Glu 
    130                 135                 140                 


Met Arg Thr Ser His His Gln Tyr Pro Ser Arg Ser Ser Gly Leu Thr 
145                 150                 155                 160 


Ala Ile Cys Thr Phe Ser Val Gly Tyr Ile Leu Trp Val Cys Trp Val 
                165                 170                 175     


His His Val Thr Gly Met Trp Val Tyr Pro Phe Leu Glu His Ile Gly 
            180                 185                 190         


Pro Gly Ala Arg Ile Ile Phe Phe Gly Ser Thr Thr Ile Leu Met Asn 
        195                 200                 205             


Phe Leu Tyr Leu Leu Gly Glu Val Leu Asn Asn Tyr Ile Trp Asp Thr 
    210                 215                 220                 


Gln Lys Thr Ala Lys Leu Lys 
225                 230     


<210>  651
<211>  134
<212>  PRT
<213>  Homo Sapiens

<400>  651

Met Ala Leu Val Pro Cys Gln Val Leu Arg Met Ala Ile Leu Leu Ser 
1               5                   10                  15      


Tyr Cys Ser Ile Leu Cys Asn Tyr Lys Ala Ile Glu Met Pro Ser His 
            20                  25                  30          


Gln Thr Tyr Gly Gly Ser Trp Lys Phe Leu Thr Phe Ile Asp Leu Val 
        35                  40                  45              


Ile Gln Ala Val Phe Phe Gly Ile Cys Val Leu Thr Asp Leu Ser Ser 
    50                  55                  60                  


Leu Leu Thr Arg Gly Ser Gly Asn Gln Glu Gln Glu Arg Gln Leu Lys 
65                  70                  75                  80  


Lys Leu Ile Ser Leu Arg Asp Trp Met Leu Ala Val Leu Ala Phe Pro 
                85                  90                  95      


Val Gly Val Phe Val Val Ala Val Phe Trp Ile Ile Tyr Ala Tyr Asp 
            100                 105                 110         


Arg Glu Met Ile Tyr Pro Lys Leu Leu Asp Asn Phe Ile Pro Gly Trp 
        115                 120                 125             


Leu Asn His Gly Met Leu 
    130                 


<210>  652
<211>  138
<212>  PRT
<213>  Homo Sapiens

<400>  652

Met Leu Ala Val Leu Ala Phe Pro Val Gly Val Phe Val Val Ala Val 
1               5                   10                  15      


Phe Trp Ile Ile Tyr Ala Tyr Asp Arg Glu Met Ile Tyr Pro Lys Leu 
            20                  25                  30          


Leu Asp Asn Phe Ile Pro Gly Trp Leu Asn His Gly Met His Thr Thr 
        35                  40                  45              


Val Leu Pro Phe Ile Leu Ile Glu Met Arg Thr Ser His His Gln Tyr 
    50                  55                  60                  


Pro Ser Arg Ser Ser Gly Leu Thr Ala Ile Cys Thr Phe Ser Val Gly 
65                  70                  75                  80  


Tyr Ile Leu Trp Val Cys Trp Val His His Val Thr Gly Met Trp Val 
                85                  90                  95      


Tyr Pro Phe Leu Glu His Ile Gly Pro Gly Ala Arg Ile Ile Phe Phe 
            100                 105                 110         


Gly Ser Thr Thr Ile Leu Met Asn Phe Leu Tyr Leu Leu Gly Glu Val 
        115                 120                 125             


Leu Asn Asn Tyr Ile Trp Asp Thr Gln Lys 
    130                 135             


<210>  653
<211>  192
<212>  PRT
<213>  Homo Sapiens

<400>  653

Met Thr Lys Val Leu Arg Met Ala Ile Leu Leu Ser Tyr Cys Ser Ile 
1               5                   10                  15      


Leu Cys Asn Tyr Lys Ala Ile Glu Met Pro Ser His Gln Thr Tyr Gly 
            20                  25                  30          


Gly Ser Trp Lys Phe Leu Thr Phe Ile Asp Leu Val Ile Gln Ala Val 
        35                  40                  45              


Phe Phe Gly Ile Cys Val Leu Thr Asp Leu Ser Ser Leu Leu Thr Arg 
    50                  55                  60                  


Gly Ser Gly Asn Gln Glu Gln Glu Arg Gln Leu Lys Lys Leu Ile Ser 
65                  70                  75                  80  


Leu Arg Asp Trp Met Leu Ala Val Leu Ala Phe Pro Val Gly Val Phe 
                85                  90                  95      


Val Val Ala Val Phe Trp Ile Ile Tyr Ala Tyr Asp Arg Glu Met Ile 
            100                 105                 110         


Tyr Pro Lys Leu Leu Asp Asn Phe Ile Pro Gly Trp Leu Asn His Gly 
        115                 120                 125             


Met His Thr Thr Val Leu Pro Phe Ile Leu Ile Glu Met Arg Thr Ser 
    130                 135                 140                 


His His Gln Tyr Pro Ser Arg Ser Ser Gly Leu Thr Ala Ile Cys Thr 
145                 150                 155                 160 


Phe Ser Val Gly Tyr Ile Leu Trp Val Cys Trp Val His His Val Thr 
                165                 170                 175     


Gly Met Trp Val Tyr Pro Phe Leu Glu His Ile Gly Pro Gly Ala Arg 
            180                 185                 190         


<210>  654
<211>  171
<212>  PRT
<213>  Homo Sapiens

<400>  654

Met Ala Lys Gln Tyr Ile Glu Lys Ser Leu Leu Val Pro Asp His Val 
1               5                   10                  15      


Ile Thr Arg Leu Met Met Ser Glu Leu Glu Asn Arg Arg Gly Gln His 
            20                  25                  30          


Trp Leu Leu Asp Gly Phe Pro Arg Thr Leu Gly Gln Ala Glu Ala Leu 
        35                  40                  45              


Asp Lys Ile Cys Glu Val Asp Leu Val Ile Ser Leu Asn Ile Pro Phe 
    50                  55                  60                  


Glu Thr Leu Lys Asp Arg Leu Ser Arg Arg Trp Ile His Pro Pro Ser 
65                  70                  75                  80  


Gly Arg Val Tyr Asn Leu Asp Phe Asn Pro Pro His Val His Gly Ile 
                85                  90                  95      


Asp Asp Val Thr Gly Glu Pro Leu Val Gln Gln Glu Asp Asp Lys Pro 
            100                 105                 110         


Glu Ala Val Ala Ala Arg Leu Arg Gln Tyr Lys Asp Val Ala Lys Pro 
        115                 120                 125             


Val Ile Glu Leu Tyr Lys Ser Arg Gly Val Leu His Gln Phe Ser Gly 
    130                 135                 140                 


Thr Glu Thr Asn Lys Ile Trp Pro Tyr Val Tyr Thr Leu Phe Ser Asn 
145                 150                 155                 160 


Lys Ile Thr Pro Ile Gln Ser Lys Glu Ala Tyr 
                165                 170     


<210>  655
<211>  223
<212>  PRT
<213>  Homo Sapiens

<400>  655

Met Ala Ser Lys Leu Leu Arg Ala Val Ile Leu Gly Pro Pro Gly Ser 
1               5                   10                  15      


Gly Lys Gly Thr Val Cys Gln Arg Ile Ala Gln Asn Phe Gly Leu Gln 
            20                  25                  30          


His Leu Ser Ser Gly His Phe Leu Arg Glu Asn Ile Lys Ala Ser Thr 
        35                  40                  45              


Glu Val Gly Glu Met Ala Lys Gln Tyr Ile Glu Lys Ser Leu Leu Val 
    50                  55                  60                  


Pro Asp His Val Ile Thr Arg Leu Met Met Ser Glu Leu Glu Asn Arg 
65                  70                  75                  80  


Arg Gly Gln His Trp Leu Leu Asp Gly Phe Pro Arg Thr Leu Gly Gln 
                85                  90                  95      


Ala Glu Ala Leu Asp Lys Ile Cys Glu Val Asp Leu Val Ile Ser Leu 
            100                 105                 110         


Asn Ile Pro Phe Glu Thr Leu Lys Asp Arg Leu Ser Arg Arg Trp Ile 
        115                 120                 125             


His Pro Pro Ser Gly Arg Val Tyr Asn Leu Asp Phe Asn Pro Pro His 
    130                 135                 140                 


Val His Gly Ile Asp Asp Val Thr Gly Glu Pro Leu Val Gln Gln Glu 
145                 150                 155                 160 


Asp Asp Lys Pro Glu Ala Val Ala Ala Arg Leu Arg Gln Tyr Lys Asp 
                165                 170                 175     


Val Ala Lys Pro Val Ile Glu Leu Tyr Lys Ser Arg Gly Val Leu His 
            180                 185                 190         


Gln Phe Ser Gly Thr Glu Thr Asn Lys Ile Trp Pro Tyr Val Tyr Thr 
        195                 200                 205             


Leu Phe Ser Asn Lys Ile Thr Pro Ile Gln Ser Lys Glu Ala Tyr 
    210                 215                 220             


<210>  656
<211>  223
<212>  PRT
<213>  Homo Sapiens

<400>  656

Met Ala Ser Lys Leu Leu Arg Ala Val Ile Leu Gly Pro Pro Gly Ser 
1               5                   10                  15      


Gly Lys Gly Thr Val Cys Gln Arg Ile Ala Gln Asn Phe Gly Leu Gln 
            20                  25                  30          


His Leu Ser Ser Gly His Phe Leu Arg Glu Asn Ile Lys Ala Ser Thr 
        35                  40                  45              


Glu Val Gly Glu Met Ala Lys Gln Tyr Ile Glu Lys Ser Leu Leu Val 
    50                  55                  60                  


Pro Asp His Val Ile Thr Arg Leu Met Met Ser Glu Leu Glu Asn Arg 
65                  70                  75                  80  


Arg Gly Gln His Trp Leu Leu Asp Gly Phe Pro Arg Thr Leu Gly Gln 
                85                  90                  95      


Ala Glu Ala Leu Asp Lys Ile Cys Glu Val Asp Leu Val Ile Ser Leu 
            100                 105                 110         


Asn Ile Pro Phe Glu Thr Leu Lys Asp Arg Leu Ser Arg Arg Trp Ile 
        115                 120                 125             


His Pro Pro Ser Gly Arg Val Tyr Asn Leu Asp Phe Asn Pro Pro His 
    130                 135                 140                 


Val His Gly Ile Asp Asp Val Thr Gly Glu Pro Leu Val Gln Gln Glu 
145                 150                 155                 160 


Asp Asp Lys Pro Glu Ala Val Ala Ala Arg Leu Arg Gln Tyr Lys Asp 
                165                 170                 175     


Val Ala Lys Pro Val Ile Glu Leu Tyr Lys Ser Arg Gly Val Leu His 
            180                 185                 190         


Gln Phe Ser Gly Thr Glu Thr Asn Lys Ile Trp Pro Tyr Val Tyr Thr 
        195                 200                 205             


Leu Phe Ser Asn Lys Ile Thr Pro Ile Gln Ser Lys Glu Ala Tyr 
    210                 215                 220             


<210>  657
<211>  223
<212>  PRT
<213>  Homo Sapiens

<400>  657

Met Ala Ser Lys Leu Leu Arg Ala Val Ile Leu Gly Pro Pro Gly Ser 
1               5                   10                  15      


Gly Lys Gly Thr Val Cys Gln Arg Ile Ala Gln Asn Phe Gly Leu Gln 
            20                  25                  30          


His Leu Ser Ser Gly His Phe Leu Arg Glu Asn Ile Lys Ala Ser Thr 
        35                  40                  45              


Glu Val Gly Glu Met Ala Lys Gln Tyr Ile Glu Lys Ser Leu Leu Val 
    50                  55                  60                  


Pro Asp His Val Ile Thr Arg Leu Met Met Ser Glu Leu Glu Asn Arg 
65                  70                  75                  80  


Arg Gly Gln His Trp Leu Leu Asp Gly Phe Pro Arg Thr Leu Gly Gln 
                85                  90                  95      


Ala Glu Ala Leu Asp Lys Ile Cys Glu Val Asp Leu Val Ile Ser Leu 
            100                 105                 110         


Asn Ile Pro Phe Glu Thr Leu Lys Asp Arg Leu Ser Arg Arg Trp Ile 
        115                 120                 125             


His Pro Pro Ser Gly Arg Val Tyr Asn Leu Asp Phe Asn Pro Pro His 
    130                 135                 140                 


Val His Gly Ile Asp Asp Val Thr Gly Glu Pro Leu Val Gln Gln Glu 
145                 150                 155                 160 


Asp Asp Lys Pro Glu Ala Val Ala Ala Arg Leu Arg Gln Tyr Lys Asp 
                165                 170                 175     


Val Ala Lys Pro Val Ile Glu Leu Tyr Lys Ser Arg Gly Val Leu His 
            180                 185                 190         


Gln Phe Ser Gly Thr Glu Thr Asn Lys Ile Trp Pro Tyr Val Tyr Thr 
        195                 200                 205             


Leu Phe Ser Asn Lys Ile Thr Pro Ile Gln Ser Lys Glu Ala Tyr 
    210                 215                 220             


<210>  658
<211>  78
<212>  PRT
<213>  Homo Sapiens

<400>  658

Leu Ala Leu Leu Ala Leu Leu Met Ser Leu Thr Gln Gly Val Leu Thr 
1               5                   10                  15      


Ala Leu Arg Leu Arg Lys Met Thr Phe Gly Arg Val Ser Asp Leu Gly 
            20                  25                  30          


Gln Phe Ile Arg Glu Ser Glu Pro Glu Pro Asp Val Arg Lys Ser Lys 
        35                  40                  45              


Gly Ser Met Phe Ser Gln Ala Met Lys Lys Trp Val Gln Gly Asn Thr 
    50                  55                  60                  


Asp Glu Ala Gln Glu Glu Leu Ala Trp Lys Ile Ala Lys Met 
65                  70                  75              


<210>  659
<211>  138
<212>  PRT
<213>  Homo Sapiens

<400>  659

Met Arg Gly Ala Gly Pro Ser Pro Arg Gln Ser Pro Arg Thr Leu Arg 
1               5                   10                  15      


Pro Asp Pro Gly Pro Ala Met Ser Phe Phe Arg Arg Lys Val Lys Gly 
            20                  25                  30          


Lys Glu Gln Glu Lys Thr Ser Asp Val Lys Ser Ile Lys Ala Leu Lys 
        35                  40                  45              


Ile Met Pro Cys Trp Arg Leu Gln Asp Gln Val Met Leu Gln Ser Met 
    50                  55                  60                  


Pro Phe Leu Pro Thr Trp Thr Pro Phe Gln Val Ala Gly Gln Pro His 
65                  70                  75                  80  


Leu Arg Ser Ser Gln Ala Thr Trp Arg Pro Leu Ile Leu Val Thr Trp 
                85                  90                  95      


Ala Asp Leu Val Trp Thr Thr Arg Leu Lys Arg Pro Asn Gln Ala Phe 
            100                 105                 110         


Leu Arg Pro Leu Asn Lys Ser Cys Thr Thr Leu Leu Ser Ser Leu Thr 
        115                 120                 125             


Ser Phe Asn Ser Trp Asn Phe Gly Glu Trp 
    130                 135             


<210>  660
<211>  150
<212>  PRT
<213>  Homo Sapiens

<400>  660

Met Arg Gly Ala Gly Pro Ser Pro Arg Gln Ser Pro Arg Thr Leu Arg 
1               5                   10                  15      


Pro Asp Pro Gly Pro Ala Met Ser Phe Phe Arg Arg Lys Val Lys Gly 
            20                  25                  30          


Lys Glu Gln Glu Lys Thr Ser Asp Val Lys Ser Ile Lys Ala Ser Ile 
        35                  40                  45              


Ser Val His Ser Pro Gln Lys Ser Thr Lys Asn His Ala Leu Leu Glu 
    50                  55                  60                  


Ala Ala Gly Pro Ser His Val Ala Ile Asn Ala Ile Ser Ala Asn Met 
65                  70                  75                  80  


Asp Ser Phe Ser Ser Ser Arg Thr Ala Thr Leu Lys Lys Gln Pro Ser 
                85                  90                  95      


His Met Glu Ala Ala His Phe Gly Asp Leu Asp Leu Val Trp Thr Thr 
            100                 105                 110         


Arg Leu Lys Arg Pro Asn Gln Ala Phe Leu Arg Pro Leu Asn Lys Ser 
        115                 120                 125             


Cys Thr Thr Leu Leu Ser Ser Leu Thr Ser Phe Asn Ser Trp Asn Phe 
    130                 135                 140                 


Gly Glu Trp Ser Ile Trp 
145                 150 


<210>  661
<211>  662
<212>  PRT
<213>  Homo Sapiens

<400>  661

Met Arg Gly Ala Gly Pro Ser Pro Arg Gln Ser Pro Arg Thr Leu Arg 
1               5                   10                  15      


Pro Asp Pro Gly Pro Ala Met Ser Phe Phe Arg Arg Lys Val Lys Gly 
            20                  25                  30          


Lys Glu Gln Glu Lys Thr Ser Asp Val Lys Ser Ile Lys Ala Ser Ile 
        35                  40                  45              


Ser Val His Ser Pro Gln Lys Ser Thr Lys Asn His Ala Leu Leu Glu 
    50                  55                  60                  


Ala Ala Gly Pro Ser His Val Ala Ile Asn Ala Ile Ser Ala Asn Met 
65                  70                  75                  80  


Asp Ser Phe Ser Ser Ser Arg Thr Ala Thr Leu Lys Lys Gln Pro Ser 
                85                  90                  95      


His Met Glu Ala Ala His Phe Gly Asp Leu Gly Arg Ser Cys Leu Asp 
            100                 105                 110         


Tyr Gln Thr Gln Glu Thr Lys Ser Ser Leu Ser Lys Thr Leu Glu Gln 
        115                 120                 125             


Val Leu His Asp Thr Ile Val Leu Pro Tyr Phe Ile Gln Phe Met Glu 
    130                 135                 140                 


Leu Arg Arg Met Glu His Leu Val Lys Phe Trp Leu Glu Ala Glu Ser 
145                 150                 155                 160 


Phe His Ser Thr Thr Trp Ser Arg Ile Arg Ala His Ser Leu Asn Thr 
                165                 170                 175     


Val Lys Gln Ser Ser Leu Ala Glu Pro Val Ser Pro Ser Lys Lys His 
            180                 185                 190         


Glu Thr Thr Ala Ser Phe Leu Thr Asp Ser Leu Asp Lys Arg Leu Glu 
        195                 200                 205             


Asp Ser Gly Ser Ala Gln Leu Phe Met Thr His Ser Glu Gly Ile Asp 
    210                 215                 220                 


Leu Asn Asn Arg Thr Asn Ser Thr Gln Asn His Leu Leu Leu Ser Gln 
225                 230                 235                 240 


Glu Cys Asp Ser Ala His Ser Leu Arg Leu Glu Met Ala Arg Ala Gly 
                245                 250                 255     


Thr His Gln Val Ser Met Glu Thr Gln Glu Ser Ser Ser Thr Leu Thr 
            260                 265                 270         


Val Ala Ser Arg Asn Ser Pro Ala Ser Pro Leu Lys Glu Leu Ser Gly 
        275                 280                 285             


Lys Leu Met Lys Ser Ile Glu Gln Asp Ala Val Asn Thr Phe Thr Lys 
    290                 295                 300                 


Tyr Ile Ser Pro Asp Ala Ala Lys Pro Ile Pro Ile Thr Glu Ala Met 
305                 310                 315                 320 


Arg Asn Asp Ile Ile Ala Arg Ile Cys Gly Glu Asp Gly Gln Val Asp 
                325                 330                 335     


Pro Asn Cys Phe Val Leu Ala Gln Ser Ile Val Phe Ser Ala Met Glu 
            340                 345                 350         


Gln Glu His Phe Ser Glu Phe Leu Arg Ser His His Phe Cys Lys Tyr 
        355                 360                 365             


Gln Ile Glu Val Leu Thr Ser Gly Thr Val Tyr Leu Ala Asp Ile Leu 
    370                 375                 380                 


Phe Cys Glu Ser Ala Leu Phe Tyr Phe Ser Glu Tyr Met Glu Lys Glu 
385                 390                 395                 400 


Asp Ala Val Asn Ile Leu Gln Phe Trp Leu Ala Ala Asp Asn Phe Gln 
                405                 410                 415     


Ser Gln Leu Ala Ala Lys Lys Gly Gln Tyr Asp Gly Gln Glu Ala Gln 
            420                 425                 430         


Asn Asp Ala Met Ile Leu Tyr Asp Lys Tyr Phe Ser Leu Gln Ala Thr 
        435                 440                 445             


His Pro Leu Gly Phe Asp Asp Val Val Arg Leu Glu Ile Glu Ser Asn 
    450                 455                 460                 


Ile Cys Arg Glu Gly Gly Pro Leu Pro Asn Cys Phe Thr Thr Pro Leu 
465                 470                 475                 480 


Arg Gln Ala Trp Thr Thr Met Glu Lys Val Phe Leu Pro Gly Phe Leu 
                485                 490                 495     


Ser Ser Asn Leu Tyr Tyr Lys Tyr Leu Asn Asp Leu Ile His Ser Val 
            500                 505                 510         


Arg Gly Asp Glu Phe Leu Gly Gly Asn Val Ser Leu Thr Ala Pro Gly 
        515                 520                 525             


Ser Val Gly Pro Pro Asp Glu Ser His Pro Gly Ser Ser Asp Ser Ser 
    530                 535                 540                 


Ala Ser Gln Ser Ser Val Lys Lys Ala Ser Ile Lys Ile Leu Lys Asn 
545                 550                 555                 560 


Phe Asp Glu Ala Ile Ile Val Asp Ala Ala Ser Leu Asp Pro Glu Ser 
                565                 570                 575     


Leu Tyr Gln Arg Thr Tyr Ala Gly Lys Met Thr Phe Gly Arg Val Ser 
            580                 585                 590         


Asp Leu Gly Gln Phe Ile Arg Glu Ser Glu Pro Glu Pro Asp Val Arg 
        595                 600                 605             


Lys Ser Lys Gly Ser Met Phe Ser Gln Ala Met Lys Lys Trp Val Gln 
    610                 615                 620                 


Gly Asn Thr Asp Glu Ala Gln Glu Glu Leu Ala Trp Lys Ile Ala Lys 
625                 630                 635                 640 


Met Ile Val Ser Asp Ile Met Gln Gln Ala Gln Tyr Asp Gln Pro Leu 
                645                 650                 655     


Glu Lys Ser Thr Lys Leu 
            660         


<210>  662
<211>  604
<212>  PRT
<213>  Homo Sapiens

<400>  662

Met Arg Gly Ala Gly Pro Ser Pro Arg Gln Ser Pro Arg Thr Leu Arg 
1               5                   10                  15      


Pro Asp Pro Gly Pro Ala Met Ser Phe Phe Arg Arg Lys Val Lys Gly 
            20                  25                  30          


Lys Glu Gln Glu Lys Thr Ser Asp Val Lys Ser Ile Lys Ala Ser Ile 
        35                  40                  45              


Ser Val His Ser Pro Gln Lys Ser Thr Lys Asn His Ala Leu Leu Glu 
    50                  55                  60                  


Ala Ala Gly Pro Ser His Val Ala Ile Asn Ala Ile Ser Ala Asn Met 
65                  70                  75                  80  


Asp Ser Phe Ser Ser Ser Arg Thr Ala Thr Leu Lys Lys Gln Pro Ser 
                85                  90                  95      


His Met Glu Ala Ala His Phe Gly Asp Leu Gly Arg Ser Cys Leu Asp 
            100                 105                 110         


Tyr Gln Thr Gln Glu Thr Lys Ser Ser Leu Ser Lys Thr Leu Glu Gln 
        115                 120                 125             


Val Leu His Asp Thr Ile Val Leu Pro Tyr Phe Ile Gln Phe Met Glu 
    130                 135                 140                 


Leu Arg Arg Met Glu His Leu Val Lys Phe Trp Leu Glu Ala Glu Ser 
145                 150                 155                 160 


Phe His Ser Thr Thr Trp Ser Arg Ile Arg Ala His Ser Leu Asn Thr 
                165                 170                 175     


Val Lys Gln Ser Ser Leu Ala Glu Pro Val Ser Pro Ser Lys Lys His 
            180                 185                 190         


Glu Thr Thr Ala Ser Phe Leu Thr Asp Ser Leu Asp Lys Arg Leu Glu 
        195                 200                 205             


Asp Ser Gly Ser Ala Gln Leu Phe Met Thr His Ser Glu Gly Ile Asp 
    210                 215                 220                 


Leu Asn Asn Arg Thr Asn Ser Thr Gln Asn His Leu Leu Leu Ser Gln 
225                 230                 235                 240 


Glu Cys Asp Ser Ala His Ser Leu Arg Leu Glu Met Ala Arg Ala Gly 
                245                 250                 255     


Thr His Gln Val Ser Met Glu Thr Gln Glu Ser Ser Ser Thr Leu Thr 
            260                 265                 270         


Val Ala Ser Arg Asn Ser Pro Ala Ser Pro Leu Lys Glu Leu Ser Gly 
        275                 280                 285             


Lys Leu Met Lys Ser Ile Glu Gln Asp Ala Val Asn Thr Phe Thr Lys 
    290                 295                 300                 


Tyr Ile Ser Pro Asp Ala Ala Lys Pro Ile Pro Ile Thr Glu Ala Met 
305                 310                 315                 320 


Arg Asn Asp Ile Ile Ala Arg Ile Cys Gly Glu Asp Gly Gln Val Asp 
                325                 330                 335     


Pro Asn Cys Phe Val Leu Ala Gln Ser Ile Val Phe Ser Ala Met Glu 
            340                 345                 350         


Gln Glu His Phe Ser Glu Phe Leu Arg Ser His His Phe Cys Lys Tyr 
        355                 360                 365             


Gln Ile Glu Val Leu Thr Ser Gly Thr Val Tyr Leu Ala Asp Ile Leu 
    370                 375                 380                 


Phe Cys Glu Ser Ala Leu Phe Tyr Phe Ser Glu Tyr Met Glu Lys Glu 
385                 390                 395                 400 


Asp Ala Val Asn Ile Leu Gln Phe Trp Leu Ala Ala Asp Asn Phe Gln 
                405                 410                 415     


Ser Gln Leu Ala Ala Lys Lys Gly Gln Tyr Asp Gly Gln Glu Ala Gln 
            420                 425                 430         


Asn Asp Ala Met Ile Leu Tyr Asp Lys Tyr Phe Ser Leu Gln Ala Thr 
        435                 440                 445             


His Pro Leu Gly Phe Asp Asp Val Val Arg Leu Glu Ile Glu Ser Asn 
    450                 455                 460                 


Ile Cys Arg Glu Gly Gly Pro Leu Pro Asn Cys Phe Thr Thr Pro Leu 
465                 470                 475                 480 


Arg Gln Ala Trp Thr Thr Met Glu Lys Ser Ser Val Lys Lys Ala Ser 
                485                 490                 495     


Ile Lys Ile Leu Lys Asn Phe Asp Glu Ala Ile Ile Val Asp Ala Ala 
            500                 505                 510         


Ser Leu Asp Pro Glu Ser Leu Tyr Gln Arg Thr Tyr Ala Gly Lys Met 
        515                 520                 525             


Thr Phe Gly Arg Val Ser Asp Leu Gly Gln Phe Ile Arg Glu Ser Glu 
    530                 535                 540                 


Pro Glu Pro Asp Val Arg Lys Ser Lys Gly Ser Met Phe Ser Gln Ala 
545                 550                 555                 560 


Met Lys Lys Trp Val Gln Gly Asn Thr Asp Glu Ala Gln Glu Glu Leu 
                565                 570                 575     


Ala Trp Lys Ile Ala Lys Met Ile Val Ser Asp Ile Met Gln Gln Ala 
            580                 585                 590         


Gln Tyr Asp Gln Pro Leu Glu Lys Ser Thr Lys Leu 
        595                 600                 


<210>  663
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  663

Met Arg Gly Ala Gly Pro Ser Pro Arg Gln Ser Pro Arg Thr Leu Arg 
1               5                   10                  15      


Pro Asp Pro Gly Pro Ala Met Ser Phe Phe Arg Arg Lys Val Lys Gly 
            20                  25                  30          


Lys Glu Gln Glu Lys Thr Ser Asp Val Lys Ser Ile Lys Gly Cys Arg 
        35                  40                  45              


Thr Lys Ser Cys Cys Asn Gln Cys His Phe Cys Gln His Gly Leu Leu 
    50                  55                  60                  


Phe Lys 
65      


<210>  664
<211>  63
<212>  PRT
<213>  Homo Sapiens

<400>  664

Met Arg Gly Ala Gly Pro Ser Pro Arg Gln Ser Pro Arg Thr Leu Arg 
1               5                   10                  15      


Pro Asp Pro Gly Pro Ala Met Ser Phe Phe Arg Arg Lys Val Lys Gly 
            20                  25                  30          


Lys Glu Gln Glu Lys Thr Ser Asp Val Lys Ser Ile Lys Val Glu Thr 
        35                  40                  45              


Glu Phe His His Val Ser Gln Tyr Gly Leu Asp Leu Leu Thr Leu 
    50                  55                  60              


<210>  665
<211>  59
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  665

Xaa Lys Tyr Ile Ser Pro Asp Ala Ala Lys Pro Ile Pro Ile Thr Glu 
1               5                   10                  15      


Ala Met Arg Asn Asp Ile Ile Ala Arg Ile Cys Gly Glu Asp Gly Gln 
            20                  25                  30          


Val Asp Pro Asn Cys Phe Val Leu Ala Gln Ser Ile Val Phe Ser Ala 
        35                  40                  45              


Met Glu Gln Asp Thr Trp Lys Lys Arg Met Gln 
    50                  55                  


<210>  666
<211>  31
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  666

Xaa Leu Thr Ala Pro Gly Ser Val Gly Pro Pro Asp Glu Ser His Pro 
1               5                   10                  15      


Gly Ser Ser Asp Ser Ser Ala Ser Gln Cys Glu Lys Ser Gln Tyr 
            20                  25                  30      


<210>  667
<211>  323
<212>  PRT
<213>  Homo Sapiens

<400>  667

Met Asp Ser Lys Tyr Gln Cys Val Lys Leu Asn Asp Gly His Phe Met 
1               5                   10                  15      


Pro Val Leu Gly Phe Gly Thr Tyr Ala Pro Ala Glu Val Pro Lys Ser 
            20                  25                  30          


Lys Ala Leu Glu Ala Thr Lys Leu Ala Ile Glu Ala Gly Phe Arg His 
        35                  40                  45              


Ile Asp Ser Ala His Leu Tyr Asn Asn Glu Glu Gln Val Gly Leu Ala 
    50                  55                  60                  


Ile Arg Ser Lys Ile Ala Asp Gly Ser Val Lys Arg Glu Asp Ile Phe 
65                  70                  75                  80  


Tyr Thr Ser Lys Leu Trp Cys Asn Ser His Arg Pro Glu Leu Val Arg 
                85                  90                  95      


Pro Ala Leu Glu Arg Ser Leu Lys Asn Leu Gln Leu Asp Tyr Val Asp 
            100                 105                 110         


Leu Tyr Leu Ile His Phe Pro Val Ser Val Lys Pro Gly Glu Glu Val 
        115                 120                 125             


Ile Pro Lys Asp Glu Asn Gly Lys Ile Leu Phe Asp Thr Val Asp Leu 
    130                 135                 140                 


Cys Ala Thr Trp Glu Ala Val Glu Lys Cys Lys Asp Ala Gly Leu Ala 
145                 150                 155                 160 


Lys Ser Ile Gly Val Ser Asn Phe Asn Arg Arg Gln Leu Glu Met Ile 
                165                 170                 175     


Leu Asn Lys Pro Gly Leu Lys Tyr Lys Pro Val Cys Asn Gln Val Glu 
            180                 185                 190         


Cys His Pro Tyr Phe Asn Gln Arg Lys Leu Leu Asp Phe Cys Lys Ser 
        195                 200                 205             


Lys Asp Ile Val Leu Val Ala Tyr Ser Ala Leu Gly Ser His Arg Glu 
    210                 215                 220                 


Glu Pro Trp Val Asp Pro Asn Ser Pro Val Leu Leu Glu Asp Pro Val 
225                 230                 235                 240 


Leu Cys Ala Leu Ala Lys Lys His Lys Arg Thr Pro Ala Leu Ile Ala 
                245                 250                 255     


Leu Arg Tyr Gln Leu Gln Arg Gly Val Val Val Leu Ala Lys Ser Tyr 
            260                 265                 270         


Asn Glu Gln Arg Ile Arg Gln Asn Val Gln Val Phe Glu Phe Gln Leu 
        275                 280                 285             


Thr Ser Glu Glu Met Lys Ala Ile Asp Gly Leu Asn Arg Asn Val Arg 
    290                 295                 300                 


Tyr Leu Thr Leu Asp Ile Phe Ala Gly Pro Pro Asn Tyr Pro Phe Ser 
305                 310                 315                 320 


Asp Glu Tyr 
            


<210>  668
<211>  205
<212>  PRT
<213>  Homo Sapiens

<400>  668

Met Gly Val Val Ser Leu Phe Leu Cys Ile Val Glu Gln Ile Phe Thr 
1               5                   10                  15      


Ser Ser Lys Lys Ile Gln Phe Arg Gly Ile Phe Met Ala Lys Val Pro 
            20                  25                  30          


Lys Ser Lys Ala Leu Glu Ala Thr Lys Leu Ala Ile Glu Ala Gly Phe 
        35                  40                  45              


Arg His Ile Asp Ser Ala His Leu Tyr Asn Asn Glu Glu Gln Val Gly 
    50                  55                  60                  


Leu Ala Ile Arg Ser Lys Ile Ala Asp Gly Ser Val Lys Arg Glu Asp 
65                  70                  75                  80  


Ile Phe Tyr Thr Ser Lys Leu Trp Cys Asn Ser His Arg Pro Glu Leu 
                85                  90                  95      


Val Arg Pro Ala Leu Glu Arg Ser Leu Lys Asn Leu Gln Leu Asp Tyr 
            100                 105                 110         


Val Asp Leu Tyr Leu Ile His Phe Pro Val Ser Val Lys Pro Gly Glu 
        115                 120                 125             


Glu Val Ile Pro Lys Asp Glu Asn Gly Lys Ile Leu Phe Asp Thr Val 
    130                 135                 140                 


Asp Leu Cys Ala Thr Trp Glu Ala Val Glu Lys Cys Lys Asp Ala Gly 
145                 150                 155                 160 


Leu Ala Lys Ser Ile Gly Val Ser Asn Phe Asn Arg Arg Gln Leu Glu 
                165                 170                 175     


Met Ile Leu Asn Lys Pro Gly Leu Lys Tyr Lys Pro Val Cys Asn Gln 
            180                 185                 190         


Pro Arg Asp Asn Ser Ile Phe Ser Leu Ser Pro Asp Trp 
        195                 200                 205 


<210>  669
<211>  248
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  669

Xaa Ser Lys Tyr Gln Cys Val Lys Leu Asn Asp Gly His Phe Met Pro 
1               5                   10                  15      


Val Leu Gly Phe Gly Thr Tyr Ala Pro Ala Glu Val Gly Leu Ala Ile 
            20                  25                  30          


Arg Ser Lys Ile Ala Asp Gly Ser Val Lys Arg Glu Asp Ile Phe Tyr 
        35                  40                  45              


Thr Ser Lys Leu Trp Cys Asn Ser His Arg Pro Glu Leu Val Arg Pro 
    50                  55                  60                  


Ala Leu Glu Arg Ser Leu Lys Asn Leu Gln Leu Asp Tyr Val Asp Leu 
65                  70                  75                  80  


Tyr Leu Ile His Phe Pro Val Ser Val Lys Pro Gly Glu Glu Val Ile 
                85                  90                  95      


Pro Lys Asp Glu Asn Gly Lys Ile Leu Phe Asp Thr Val Asp Leu Cys 
            100                 105                 110         


Ala Thr Trp Glu Ala Val Glu Lys Cys Lys Asp Ala Gly Leu Ala Lys 
        115                 120                 125             


Ser Ile Gly Val Ser Asn Phe Asn Arg Arg Gln Leu Glu Met Ile Leu 
    130                 135                 140                 


Asn Lys Pro Gly Leu Lys Tyr Lys Pro Val Cys Asn Gln Val Glu Cys 
145                 150                 155                 160 


His Pro Tyr Phe Asn Gln Arg Lys Leu Leu Asp Phe Cys Lys Ser Lys 
                165                 170                 175     


Asp Ile Val Leu Val Ala Tyr Ser Ala Leu Gly Ser His Arg Glu Glu 
            180                 185                 190         


Pro Trp Val Asp Pro Asn Ser Pro Val Leu Leu Glu Asp Pro Val Leu 
        195                 200                 205             


Cys Ala Leu Ala Lys Lys His Lys Arg Thr Pro Ala Leu Ile Ala Leu 
    210                 215                 220                 


Arg Tyr Gln Leu Gln Arg Gly Val Val Val Leu Ala Lys Ser Tyr Asn 
225                 230                 235                 240 


Glu Gln Arg Ile Arg Gln Asn Val 
                245             


<210>  670
<211>  172
<212>  PRT
<213>  Homo Sapiens

<400>  670

Met Pro Val Pro Ala Ser Trp Pro His Leu Pro Ser Pro Phe Leu Leu 
1               5                   10                  15      


Met Thr Leu Leu Leu Gly Arg Leu Thr Gly Val Ala Gly Glu Asp Glu 
            20                  25                  30          


Leu Gln Val Ile Gln Pro Glu Lys Ser Val Ser Val Ala Ala Gly Glu 
        35                  40                  45              


Ser Ala Thr Leu Arg Cys Ala Met Thr Ser Leu Ile Pro Val Gly Pro 
    50                  55                  60                  


Ile Met Trp Phe Arg Gly Ala Gly Ala Gly Arg Glu Leu Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Glu Leu Thr 
                85                  90                  95      


Lys Arg Asn Asn Leu Asp Phe Ser Ile Ser Ile Ser Asn Ile Thr Pro 
            100                 105                 110         


Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser Pro 
        115                 120                 125             


Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val Arg 
    130                 135                 140                 


Ala Phe Phe Gln Glu Ser His Met Cys Ser Met Cys Asn Lys Arg Arg 
145                 150                 155                 160 


Cys His Arg Leu Tyr Gln Leu Gly Ser Gln Ser Ser 
                165                 170         


<210>  671
<211>  177
<212>  PRT
<213>  Homo Sapiens

<400>  671

Met Pro Val Pro Ala Ser Trp Pro His Pro Pro Cys Pro Phe Leu Leu 
1               5                   10                  15      


Leu Thr Leu Leu Leu Gly Leu Thr Gly Val Ala Gly Glu Asp Glu Leu 
            20                  25                  30          


Gln Val Ile Gln Pro Glu Lys Ser Val Ser Val Ala Ala Gly Glu Ser 
        35                  40                  45              


Ala Thr Leu Arg Cys Ala Met Thr Ser Leu Ile Pro Val Gly Pro Ile 
    50                  55                  60                  


Met Trp Phe Arg Gly Ala Gly Ala Gly Arg Glu Leu Ile Tyr Asn Gln 
65                  70                  75                  80  


Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Glu Leu Thr Lys 
                85                  90                  95      


Arg Asn Asn Leu Asp Phe Ser Ile Ser Ile Ser Asn Ile Thr Pro Ala 
            100                 105                 110         


Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser Pro Asp 
        115                 120                 125             


Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val Arg Gly 
    130                 135                 140                 


Val Thr His Val Phe His Val Gln Gln Thr Glu Met Ser Gln Thr Val 
145                 150                 155                 160 


Ser Thr Gly Glu Ser Ile Ile Leu Ser Cys Ser Val Pro Asn Thr Leu 
                165                 170                 175     


Pro 
    


<210>  672
<211>  140
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  672

Xaa Leu Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr 
1               5                   10                  15      


Val Ser Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile 
            20                  25                  30          


Ser Asn Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe 
        35                  40                  45              


Arg Lys Gly Ser Pro Asp His Val Glu Phe Lys Ser Gly Ala Gly Thr 
    50                  55                  60                  


Glu Leu Ser Val Arg Glu Ala Arg Thr Val Phe Ser Ala Arg Ser Thr 
65                  70                  75                  80  


Glu Ser Arg Ala Ser Pro Gly Gln Ala Phe Arg Gln Ser Lys Leu Gln 
                85                  90                  95      


Val Ser Pro Gln Cys Pro Ser Leu Pro Pro His Ser Thr His Leu Cys 
            100                 105                 110         


Leu Pro Tyr Cys Cys Ile Cys Cys Leu Asn Trp Gln Ser Leu Thr Val 
        115                 120                 125             


Leu Glu Ala Arg Ser Leu Lys Ser Ala Ser Leu Asp 
    130                 135                 140 


<210>  673
<211>  45
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  673

Xaa Val His Lys Ala Val Val Glu Val Asp Glu Ser Gly Thr Arg Ala 
1               5                   10                  15      


Ala Ala Ala Thr Gly Thr Ile Phe Thr Phe Arg Tyr Ser Leu Asn Gly 
            20                  25                  30          


His Cys Val Pro Gly Thr Val Pro Ser Ala Glu Glu Lys 
        35                  40                  45  


<210>  674
<211>  85
<212>  PRT
<213>  Homo Sapiens

<400>  674

Lys Lys Glu His Val Phe Ile His Glu Arg Pro Arg Lys Ile Asn Gly 
1               5                   10                  15      


Ile Cys Ile Ser Pro Lys Lys Val Ala Cys Gln Asn Leu Ser Ala Ile 
            20                  25                  30          


Phe Cys Phe Gln Ser Glu Thr Lys Phe Lys Met Thr Val Cys Gln Leu 
        35                  40                  45              


Ile Glu Gly Thr Arg Tyr Pro Ala Cys Arg Tyr His Tyr Ser Pro Thr 
    50                  55                  60                  


Glu Gly Phe Val Leu Val Thr Cys Asp Asp Leu Arg Pro Asp Ser Phe 
65                  70                  75                  80  


Leu Gly Tyr Val Lys 
                85  


<210>  675
<211>  96
<212>  PRT
<213>  Homo Sapiens

<400>  675

Met Ile Ile Met Val Ile Ile Phe Leu Val Leu Leu Phe Trp Glu Asn 
1               5                   10                  15      


Glu Val Asn Asp Glu Ala Val Met Ser Thr Leu Glu His Leu His Val 
            20                  25                  30          


Asp Tyr Pro Gln Asn Asp Val Pro Val Pro Ala Arg Arg Asp Tyr Thr 
        35                  40                  45              


Thr Ser Glu Met Glu Thr Phe Pro Leu Leu Leu Leu Ser Leu Gly Leu 
    50                  55                  60                  


Val Leu Ala Glu Ala Ser Glu Ser Thr Met Lys Ile Ile Lys Glu Glu 
65                  70                  75                  80  


Phe Thr Asp Glu Glu Met Gln Tyr Asp Met Ala Lys Ser Gly Gln Glu 
                85                  90                  95      


<210>  676
<211>  31
<212>  PRT
<213>  Homo Sapiens

<400>  676

Met Val Met Gly Leu Gly Val Leu Leu Leu Val Phe Val Leu Gly Leu 
1               5                   10                  15      


Gly Leu Thr Pro Pro Thr Leu Ala Gln Asp Asn Ser Arg His Leu 
            20                  25                  30      


<210>  677
<211>  190
<212>  PRT
<213>  Homo Sapiens

<400>  677

Met Cys Leu Cys Val Cys Leu Tyr Val Cys Ile Cys Val Tyr Val Cys 
1               5                   10                  15      


Val Cys His Phe Val Cys Phe Trp Val Cys Leu Pro Leu Arg Val Ser 
            20                  25                  30          


Val Tyr Leu Tyr Leu Arg Val Cys Val Cys Val Cys Val Phe Val Cys 
        35                  40                  45              


Leu Cys Met Cys Val Arg Gly Cys Val Ser Val Cys Val Cys Val Cys 
    50                  55                  60                  


Ile Glu Arg Glu Gly Glu Arg Lys Gly Ala Thr Asp Gly Ser Ala Trp 
65                  70                  75                  80  


Lys Val Tyr Pro His Ser Gln Pro Trp Glu Glu Ser Val Asn Pro Pro 
                85                  90                  95      


Thr Gly Gln Asp Gln Leu Trp Trp Cys Leu Ala Asp Ser Gly Asn Val 
            100                 105                 110         


Thr Phe His Leu Arg Met Gly Leu His Phe Leu Gly Lys Glu Cys Arg 
        115                 120                 125             


Ser Trp Ser Leu Lys Glu Cys Phe Phe Phe Pro Phe Val Ile Glu Arg 
    130                 135                 140                 


Ala Gln Pro Cys Val His Trp Leu Thr Val Thr Asn Leu Arg Val Gly 
145                 150                 155                 160 


Asp Ser His Arg Glu Glu Thr Glu Gly Thr Ala Asp Ser Glu Gln Glu 
                165                 170                 175     


Ser Gly Gly Thr Ser Leu Pro Leu Gly Pro Asn Pro Gln Leu 
            180                 185                 190 


<210>  678
<211>  23
<212>  PRT
<213>  Homo Sapiens

<400>  678

Met Ser Arg Leu Val Arg Gly Ser Ser Leu Leu Thr Tyr Leu Val Val 
1               5                   10                  15      


Ala Leu Val Leu Gln Ser Arg 
            20              


<210>  679
<211>  1266
<212>  PRT
<213>  Homo Sapiens

<400>  679

Met Gly Pro Leu Met Val Leu Phe Cys Leu Leu Phe Leu Tyr Pro Gly 
1               5                   10                  15      


Leu Ala Asp Ser Ala Pro Ser Cys Pro Gln Asn Val Asn Ile Ser Gly 
            20                  25                  30          


Gly Thr Phe Thr Leu Ser His Gly Trp Ala Pro Gly Ser Leu Leu Thr 
        35                  40                  45              


Tyr Ser Cys Pro Gln Gly Leu Tyr Pro Ser Pro Ala Ser Arg Leu Cys 
    50                  55                  60                  


Lys Ser Ser Gly Gln Trp Gln Thr Pro Gly Ala Thr Arg Ser Leu Ser 
65                  70                  75                  80  


Lys Ala Val Cys Lys Pro Gly His Cys Pro Asn Pro Gly Ile Ser Leu 
                85                  90                  95      


Gly Ala Val Arg Thr Gly Phe Arg Phe Gly His Gly Asp Lys Val Arg 
            100                 105                 110         


Tyr Arg Cys Ser Ser Asn Leu Val Leu Thr Gly Ser Ser Glu Arg Glu 
        115                 120                 125             


Cys Gln Gly Asn Gly Val Trp Ser Gly Thr Glu Pro Ile Cys Arg Gln 
    130                 135                 140                 


Pro Tyr Ser Tyr Asp Phe Pro Glu Asp Val Ala Pro Ala Leu Gly Thr 
145                 150                 155                 160 


Ser Phe Ser His Met Leu Gly Ala Thr Asn Pro Thr Gln Lys Thr Lys 
                165                 170                 175     


Asp His Glu Asn Gly Thr Gly Thr Asn Thr Tyr Ala Ala Leu Asn Ser 
            180                 185                 190         


Val Tyr Leu Met Met Asn Asn Gln Met Arg Leu Leu Gly Met Glu Thr 
        195                 200                 205             


Met Ala Trp Gln Glu Ile Arg His Ala Ile Ile Leu Leu Thr Asp Gly 
    210                 215                 220                 


Lys Ser Asn Met Gly Gly Ser Pro Lys Thr Ala Val Asp His Ile Arg 
225                 230                 235                 240 


Glu Ile Leu Asn Ile Asn Gln Lys Arg Asn Asp Tyr Leu Asp Ile Tyr 
                245                 250                 255     


Ala Ile Gly Val Gly Lys Leu Asp Val Asp Trp Arg Glu Leu Asn Glu 
            260                 265                 270         


Leu Gly Ser Lys Lys Asp Gly Glu Arg His Ala Phe Ile Leu Gln Asp 
        275                 280                 285             


Thr Lys Ala Leu His Gln Val Phe Glu His Met Leu Asp Val Ser Lys 
    290                 295                 300                 


Leu Thr Asp Thr Ile Cys Gly Val Gly Asn Met Ser Ala Asn Ala Ser 
305                 310                 315                 320 


Asp Gln Glu Arg Thr Pro Trp His Val Thr Ile Lys Pro Lys Ser Gln 
                325                 330                 335     


Glu Thr Cys Arg Gly Ala Leu Ile Ser Asp Gln Trp Val Leu Thr Ala 
            340                 345                 350         


Ala His Cys Phe Arg Asp Gly Asn Asp His Ser Leu Trp Arg Val Asn 
        355                 360                 365             


Val Gly Asp Pro Lys Ser Gln Trp Gly Lys Glu Phe Leu Ile Glu Lys 
    370                 375                 380                 


Ala Val Ile Ser Pro Gly Phe Asp Val Phe Ala Lys Lys Asn Gln Gly 
385                 390                 395                 400 


Ile Leu Glu Phe Tyr Gly Asp Asp Ile Ala Leu Leu Lys Leu Ala Gln 
                405                 410                 415     


Lys Val Lys Met Ser Thr His Ala Arg Pro Ile Cys Leu Pro Cys Thr 
            420                 425                 430         


Met Glu Ala Asn Leu Ala Leu Arg Arg Pro Gln Gly Ser Thr Cys Arg 
        435                 440                 445             


Asp His Glu Asn Glu Leu Leu Asn Lys Gln Ser Val Pro Ala His Phe 
    450                 455                 460                 


Val Ala Leu Asn Gly Ser Lys Leu Asn Ile Asn Leu Lys Met Gly Val 
465                 470                 475                 480 


Glu Trp Thr Ser Cys Ala Glu Val Val Ser Gln Glu Lys Thr Met Phe 
                485                 490                 495     


Pro Asn Leu Thr Asp Val Arg Glu Val Val Thr Asp Gln Phe Leu Cys 
            500                 505                 510         


Ser Gly Thr Gln Glu Asp Glu Ser Pro Cys Lys Gly Val Thr Thr Thr 
        515                 520                 525             


Pro Trp Ser Leu Ala Arg Pro Gln Gly Ser Cys Ser Leu Glu Gly Val 
    530                 535                 540                 


Glu Ile Lys Gly Gly Ser Phe Arg Leu Leu Gln Glu Gly Gln Ala Leu 
545                 550                 555                 560 


Glu Tyr Val Cys Pro Ser Gly Phe Tyr Pro Tyr Pro Val Gln Thr Arg 
                565                 570                 575     


Thr Cys Arg Ser Thr Gly Ser Trp Ser Thr Leu Lys Thr Gln Asp Gln 
            580                 585                 590         


Lys Thr Val Arg Lys Ala Glu Cys Arg Ala Ile His Cys Pro Arg Pro 
        595                 600                 605             


His Asp Phe Glu Asn Gly Glu Tyr Trp Pro Arg Ser Pro Tyr Tyr Asn 
    610                 615                 620                 


Val Ser Asp Glu Ile Ser Phe His Cys Tyr Asp Gly Tyr Thr Leu Arg 
625                 630                 635                 640 


Gly Ser Ala Asn Arg Thr Cys Gln Val Asn Gly Arg Trp Ser Gly Gln 
                645                 650                 655     


Thr Ala Ile Cys Asp Asn Gly Ala Gly Tyr Cys Ser Asn Pro Gly Ile 
            660                 665                 670         


Pro Ile Gly Thr Arg Lys Val Gly Ser Gln Tyr Arg Leu Glu Asp Ser 
        675                 680                 685             


Val Thr Tyr His Cys Ser Arg Gly Leu Thr Leu Arg Gly Ser Gln Arg 
    690                 695                 700                 


Arg Thr Cys Gln Glu Gly Gly Ser Trp Ser Gly Thr Glu Pro Ser Cys 
705                 710                 715                 720 


Gln Asp Ser Phe Met Tyr Asp Thr Pro Gln Glu Val Ala Glu Ala Phe 
                725                 730                 735     


Leu Ser Ser Leu Thr Glu Thr Ile Glu Gly Val Asp Ala Glu Asp Gly 
            740                 745                 750         


His Gly Pro Gly Glu Gln Gln Lys Arg Lys Ile Val Leu Asp Pro Ser 
        755                 760                 765             


Gly Ser Met Asn Ile Tyr Leu Val Leu Asp Gly Ser Asp Ser Ile Gly 
    770                 775                 780                 


Ala Ser Asn Phe Thr Gly Ala Lys Lys Cys Leu Val Asn Leu Ile Glu 
785                 790                 795                 800 


Lys Val Ala Ser Tyr Gly Val Lys Pro Arg Tyr Gly Leu Val Thr Tyr 
                805                 810                 815     


Ala Thr Tyr Pro Lys Ile Trp Val Lys Val Ser Glu Ala Asp Ser Ser 
            820                 825                 830         


Asn Ala Asp Trp Val Thr Lys Gln Leu Asn Glu Ile Asn Tyr Glu Asp 
        835                 840                 845             


His Lys Leu Lys Ser Gly Thr Asn Thr Lys Lys Ala Leu Gln Ala Val 
    850                 855                 860                 


Tyr Ser Met Met Ser Trp Pro Asp Asp Val Pro Pro Glu Gly Trp Asn 
865                 870                 875                 880 


Arg Thr Arg His Val Ile Ile Leu Met Thr Asp Gly Leu His Asn Met 
                885                 890                 895     


Gly Gly Asp Pro Ile Thr Val Ile Asp Glu Ile Arg Asp Leu Leu Tyr 
            900                 905                 910         


Ile Gly Lys Asp Arg Lys Asn Pro Arg Glu Asp Tyr Leu Asp Val Tyr 
        915                 920                 925             


Val Phe Gly Val Gly Pro Leu Val Asn Gln Val Asn Ile Asn Ala Leu 
    930                 935                 940                 


Ala Ser Lys Lys Asp Asn Glu Gln His Val Phe Lys Val Lys Asp Met 
945                 950                 955                 960 


Glu Asn Leu Glu Asp Val Phe Tyr Gln Met Ile Asp Glu Ser Gln Ser 
                965                 970                 975     


Leu Ser Leu Cys Gly Met Val Trp Glu His Arg Lys Gly Thr Asp Tyr 
            980                 985                 990         


His Lys Gln Pro Trp Gln Ala Lys  Ile Ser Val Ile Arg  Pro Ser Lys 
        995                 1000                 1005             


Gly His  Glu Ser Cys Met Gly  Ala Val Val Ser Glu  Tyr Phe Val 
    1010                 1015                 1020             


Leu Thr  Ala Ala His Cys Phe  Thr Val Asp Asp Lys  Glu His Ser 
    1025                 1030                 1035             


Ile Lys  Val Ser Val Gly Gly  Glu Lys Arg Asp Leu  Glu Ile Glu 
    1040                 1045                 1050             


Val Val  Leu Phe His Pro Asn  Tyr Asn Ile Asn Gly  Lys Lys Glu 
    1055                 1060                 1065             


Ala Gly  Ile Pro Glu Phe Tyr  Asp Tyr Asp Val Ala  Leu Ile Lys 
    1070                 1075                 1080             


Leu Lys  Asn Lys Leu Lys Tyr  Gly Gln Thr Ile Arg  Pro Ile Cys 
    1085                 1090                 1095             


Leu Pro  Cys Thr Glu Gly Thr  Thr Arg Ala Leu Arg  Leu Pro Pro 
    1100                 1105                 1110             


Thr Thr  Thr Cys Gln Gln Gln  Lys Glu Glu Leu Leu  Pro Ala Gln 
    1115                 1120                 1125             


Asp Ile  Lys Ala Leu Phe Val  Ser Glu Glu Glu Lys  Lys Leu Thr 
    1130                 1135                 1140             


Arg Lys  Glu Val Tyr Ile Lys  Asn Gly Asp Lys Lys  Gly Ser Cys 
    1145                 1150                 1155             


Glu Arg  Asp Ala Gln Tyr Ala  Pro Gly Tyr Asp Lys  Val Lys Asp 
    1160                 1165                 1170             


Ile Ser  Glu Val Val Thr Pro  Arg Phe Leu Cys Thr  Gly Gly Val 
    1175                 1180                 1185             


Ser Pro  Tyr Ala Asp Pro Asn  Thr Cys Arg Gly Asp  Ser Gly Gly 
    1190                 1195                 1200             


Pro Leu  Ile Val His Lys Arg  Ser Arg Phe Ile Gln  Val Gly Val 
    1205                 1210                 1215             


Ile Ser  Trp Gly Val Val Asp  Val Cys Lys Asn Gln  Lys Arg Gln 
    1220                 1225                 1230             


Lys Gln  Val Pro Ala His Ala  Arg Asp Phe His Ile  Asn Leu Phe 
    1235                 1240                 1245             


Gln Val  Leu Pro Trp Leu Lys  Glu Lys Leu Gln Asp  Glu Asp Leu 
    1250                 1255                 1260             


Gly Phe  Leu 
    1265     


<210>  680
<211>  1115
<212>  PRT
<213>  Homo Sapiens

<400>  680

Met Gly Pro Leu Met Val Leu Phe Cys Leu Leu Phe Leu Tyr Pro Gly 
1               5                   10                  15      


Leu Ala Asp Ser Ala Pro Ser Cys Pro Gln Asn Val Asn Ile Ser Gly 
            20                  25                  30          


Gly Thr Phe Thr Leu Ser His Gly Trp Ala Pro Gly Ser Leu Leu Thr 
        35                  40                  45              


Tyr Ser Cys Pro Gln Gly Leu Tyr Pro Ser Pro Ala Ser Arg Leu Cys 
    50                  55                  60                  


Lys Ser Ser Gly Gln Trp Gln Thr Pro Gly Ala Thr Arg Ser Leu Ser 
65                  70                  75                  80  


Lys Ala Val Cys Lys Pro Val Arg Cys Pro Ala Pro Val Ser Phe Glu 
                85                  90                  95      


Asn Gly Ile Tyr Thr Pro Arg Leu Gly Ser Tyr Pro Val Gly Gly Asn 
            100                 105                 110         


Val Ser Phe Glu Cys Glu Asp Gly Phe Ile Leu Arg Gly Ser Pro Val 
        115                 120                 125             


Arg Gln Cys Arg Pro Asn Gly Met Trp Asp Gly Glu Thr Ala Val Cys 
    130                 135                 140                 


Asp Asn Gly Asp His Glu Asn Gly Thr Gly Thr Asn Thr Tyr Ala Ala 
145                 150                 155                 160 


Leu Asn Ser Val Tyr Leu Met Met Asn Asn Gln Met Arg Leu Leu Gly 
                165                 170                 175     


Met Glu Thr Met Ala Trp Gln Glu Ile Arg His Ala Ile Ile Leu Leu 
            180                 185                 190         


Thr Asp Gly Lys Ser Asn Met Gly Gly Ser Pro Lys Thr Ala Val Asp 
        195                 200                 205             


His Ile Arg Glu Ile Leu Asn Ile Asn Gln Lys Arg Asn Asp Tyr Leu 
    210                 215                 220                 


Asp Val Ser Lys Leu Thr Asp Thr Ile Cys Gly Val Gly Asn Met Ser 
225                 230                 235                 240 


Ala Asn Ala Ser Asp Gln Glu Arg Thr Pro Trp His Val Thr Ile Lys 
                245                 250                 255     


Pro Lys Ser Gln Glu Thr Cys Arg Gly Ala Leu Ile Ser Asp Gln Trp 
            260                 265                 270         


Val Leu Thr Ala Ala His Cys Phe Arg Asp Gly Asn Asp His Ser Leu 
        275                 280                 285             


Trp Arg Val Asn Val Gly Asp Pro Lys Ser Gln Trp Gly Lys Glu Phe 
    290                 295                 300                 


Leu Ile Glu Lys Ala Val Ile Ser Pro Gly Phe Asp Val Phe Ala Lys 
305                 310                 315                 320 


Lys Asn Gln Gly Ile Leu Glu Phe Tyr Gly Asp Asp Ile Ala Leu Leu 
                325                 330                 335     


Lys Leu Ala Gln Lys Val Lys Met Ser Thr His Ala Arg Pro Ile Cys 
            340                 345                 350         


Leu Pro Cys Thr Met Glu Ala Asn Leu Ala Leu Arg Arg Pro Gln Gly 
        355                 360                 365             


Ser Thr Cys Arg Asp His Glu Asn Glu Leu Leu Asn Lys Gln Ser Val 
    370                 375                 380                 


Pro Ala His Phe Val Ala Leu Asn Gly Ser Lys Leu Asn Ile Asn Leu 
385                 390                 395                 400 


Lys Met Gly Val Glu Trp Thr Ser Cys Ala Glu Val Val Ser Gln Glu 
                405                 410                 415     


Lys Thr Met Phe Pro Asn Leu Thr Asp Val Arg Glu Val Val Thr Asp 
            420                 425                 430         


Gln Phe Leu Cys Ser Gly Thr Gln Glu Asp Glu Ser Pro Cys Lys Gly 
        435                 440                 445             


Gly Ser Ala Ile His Cys Pro Arg Pro His Asp Phe Glu Asn Gly Glu 
    450                 455                 460                 


Tyr Trp Pro Arg Ser Pro Tyr Tyr Asn Val Ser Asp Glu Ile Ser Phe 
465                 470                 475                 480 


His Cys Tyr Asp Gly Tyr Thr Leu Arg Gly Ser Ala Asn Arg Thr Cys 
                485                 490                 495     


Gln Val Asn Gly Arg Trp Ser Gly Gln Thr Ala Ile Cys Asp Asn Gly 
            500                 505                 510         


Ala Gly Tyr Cys Ser Asn Pro Gly Ile Pro Ile Gly Thr Arg Lys Val 
        515                 520                 525             


Gly Ser Gln Tyr Arg Leu Glu Asp Ser Val Thr Tyr His Cys Ser Arg 
    530                 535                 540                 


Gly Leu Thr Leu Arg Gly Ser Gln Arg Arg Thr Cys Gln Glu Gly Gly 
545                 550                 555                 560 


Ser Trp Ser Gly Thr Glu Pro Ser Cys Gln Asp Ser Phe Met Tyr Asp 
                565                 570                 575     


Thr Pro Gln Glu Val Ala Glu Ala Phe Leu Ser Ser Leu Thr Glu Thr 
            580                 585                 590         


Ile Glu Gly Val Asp Ala Glu Asp Gly His Gly Pro Gly Glu Gln Gln 
        595                 600                 605             


Lys Arg Lys Ile Val Leu Asp Pro Ser Gly Ser Met Asn Ile Tyr Leu 
    610                 615                 620                 


Val Leu Asp Gly Ser Asp Ser Ile Gly Ala Ser Asn Phe Thr Gly Ala 
625                 630                 635                 640 


Lys Lys Cys Leu Val Asn Leu Ile Glu Lys Val Ala Ser Tyr Gly Val 
                645                 650                 655     


Lys Pro Arg Tyr Gly Leu Val Thr Tyr Ala Thr Tyr Pro Lys Ile Trp 
            660                 665                 670         


Val Lys Val Ser Glu Ala Asp Ser Ser Asn Ala Asp Trp Val Thr Lys 
        675                 680                 685             


Gln Leu Asn Glu Ile Asn Tyr Glu Asp His Lys Leu Lys Ser Gly Thr 
    690                 695                 700                 


Asn Thr Lys Lys Ala Leu Gln Ala Val Tyr Ser Met Met Ser Trp Pro 
705                 710                 715                 720 


Asp Asp Val Pro Pro Glu Gly Trp Asn Arg Thr Arg His Val Ile Ile 
                725                 730                 735     


Leu Met Thr Asp Gly Leu His Asn Met Gly Gly Asp Pro Ile Thr Val 
            740                 745                 750         


Ile Asp Glu Ile Arg Asp Leu Leu Tyr Ile Gly Lys Asp Arg Lys Asn 
        755                 760                 765             


Pro Arg Glu Asp Tyr Leu Asp Val Tyr Val Phe Gly Val Gly Pro Leu 
    770                 775                 780                 


Val Asn Gln Val Asn Ile Asn Ala Leu Ala Ser Lys Lys Asp Asn Glu 
785                 790                 795                 800 


Gln His Val Phe Lys Val Lys Asp Met Glu Asn Leu Glu Asp Val Phe 
                805                 810                 815     


Tyr Gln Met Ile Asp Glu Ser Gln Ser Leu Ser Leu Cys Gly Met Val 
            820                 825                 830         


Trp Glu His Arg Lys Gly Thr Asp Tyr His Lys Gln Pro Trp Gln Ala 
        835                 840                 845             


Lys Ile Ser Val Ile Arg Pro Ser Lys Gly His Glu Ser Cys Met Gly 
    850                 855                 860                 


Ala Val Val Ser Glu Tyr Phe Val Leu Thr Ala Ala His Cys Phe Thr 
865                 870                 875                 880 


Val Asp Asp Lys Glu His Ser Ile Lys Val Ser Val Gly Gly Glu Lys 
                885                 890                 895     


Arg Asp Leu Glu Ile Glu Val Val Leu Phe His Pro Asn Tyr Asn Ile 
            900                 905                 910         


Asn Gly Lys Lys Glu Ala Gly Ile Pro Glu Phe Tyr Asp Tyr Asp Val 
        915                 920                 925             


Ala Leu Ile Lys Leu Lys Asn Lys Leu Lys Tyr Gly Gln Thr Ile Arg 
    930                 935                 940                 


Pro Ile Cys Leu Pro Cys Thr Glu Gly Thr Thr Arg Ala Leu Arg Leu 
945                 950                 955                 960 


Pro Pro Thr Thr Thr Cys Gln Gln Gln Lys Glu Glu Leu Leu Pro Ala 
                965                 970                 975     


Gln Asp Ile Lys Ala Leu Phe Val Ser Glu Glu Glu Lys Lys Leu Thr 
            980                 985                 990         


Arg Lys Glu Val Tyr Ile Lys Asn  Gly Asp Lys Lys Gly  Ser Cys Glu 
        995                 1000                 1005             


Arg Asp  Ala Gln Tyr Ala Pro  Gly Tyr Asp Lys Val  Lys Asp Ile 
    1010                 1015                 1020             


Ser Glu  Val Val Thr Pro Arg  Phe Leu Cys Thr Gly  Gly Val Ser 
    1025                 1030                 1035             


Pro Tyr  Ala Asp Pro Asn Thr  Cys Arg Gly Asp Ser  Gly Gly Pro 
    1040                 1045                 1050             


Leu Ile  Val His Lys Arg Ser  Arg Phe Ile Gln Val  Gly Val Ile 
    1055                 1060                 1065             


Ser Trp  Gly Val Val Asp Val  Cys Lys Asn Gln Lys  Arg Gln Lys 
    1070                 1075                 1080             


Gln Val  Pro Ala His Ala Arg  Asp Phe His Ile Asn  Leu Phe Gln 
    1085                 1090                 1095             


Val Leu  Pro Trp Leu Lys Glu  Lys Leu Gln Asp Glu  Asp Leu Gly 
    1100                 1105                 1110             


Phe Leu  
    1115 


<210>  681
<211>  175
<212>  PRT
<213>  Homo Sapiens

<400>  681

Met Gly His Glu Gln Asn Gln Gly Ala Ala Leu Leu Gln Met Leu Pro 
1               5                   10                  15      


Leu Leu Trp Leu Leu Pro His Ser Trp Ala Val Pro Glu Glu Gln Ser 
            20                  25                  30          


Met Ile Thr Phe Leu Pro Leu Leu Leu Gly Leu Ser Leu Gly Cys Thr 
        35                  40                  45              


Gly Ala Gly Gly Phe Val Ala His Val Glu Ser Thr Cys Leu Leu Asp 
    50                  55                  60                  


Asp Ala Gly Thr Pro Lys Asp Phe Thr Tyr Cys Ile Ser Phe Asn Lys 
65                  70                  75                  80  


Asp Leu Leu Thr Cys Trp Asp Pro Glu Glu Asn Lys Met Ala Pro Cys 
                85                  90                  95      


Glu Phe Gly Val Leu Asn Ser Leu Ala Asn Val Leu Ser Gln His Leu 
            100                 105                 110         


Asn Gln Lys Asp Thr Leu Met Gln Arg Leu Arg Asn Gly Leu Gln Asn 
        115                 120                 125             


Cys Ala Thr His Thr Gln Pro Phe Trp Gly Ser Leu Thr Asn Arg Thr 
    130                 135                 140                 


Arg Pro Pro Ser Val Gln Val Ala Lys Thr Thr Pro Phe Asn Thr Arg 
145                 150                 155                 160 


Glu Pro Val Met Leu Ala Cys Tyr Val Trp Gly Phe Tyr Pro Ala 
                165                 170                 175 


<210>  682
<211>  63
<212>  PRT
<213>  Homo Sapiens

<400>  682

Met Gly Thr Ser Ser Ile Phe Leu Cys Val Leu Phe Leu Cys Gly Ala 
1               5                   10                  15      


Leu Gly Leu Thr Met Ser Pro Ala Arg Gly Arg Leu Arg Cys Tyr Ile 
            20                  25                  30          


Cys Gly Phe Thr Lys Pro Cys His Pro Val Pro Thr Glu Cys Arg Asp 
        35                  40                  45              


Asp Glu Ala Cys Gly Ile Ser Ile Gly Thr Ser Asp Ala His Cys 
    50                  55                  60              


<210>  683
<211>  33
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  683

Xaa Leu Gly Leu Thr Tyr Leu Ser Leu Leu Leu Ile Pro Ala Ala Gly 
1               5                   10                  15      


Ala Ser Ser Cys Pro Arg Thr Pro Leu Pro Ala Met Ala Pro Leu Pro 
            20                  25                  30          


Gln 
    


<210>  684
<211>  198
<212>  PRT
<213>  Homo Sapiens

<400>  684

Met Leu Ser Glu Leu Gln Asp Gly Lys Ser Lys Ile Val Gln Lys Ala 
1               5                   10                  15      


Ala Pro Glu Val Gln Glu Asp Val Lys Ala Phe Lys Thr Asp Leu Pro 
            20                  25                  30          


Ser Ser Leu Val Ser Val Ser Leu Arg Lys Pro Phe Ser Gly Pro Gln 
        35                  40                  45              


Glu Gln Glu Gln Ile Ser Gly Lys Val Thr His Leu Ile Gln Asn Asn 
    50                  55                  60                  


Met Pro Gly Asn Tyr Val Phe Ser Tyr Asp Gln Phe Phe Arg Asp Lys 
65                  70                  75                  80  


Ile Met Glu Lys Lys Gln Asp His Thr Tyr Arg Val Phe Lys Thr Val 
                85                  90                  95      


Asn Arg Trp Ala Asp Ala Tyr Pro Phe Ala Gln His Phe Ser Glu Ala 
            100                 105                 110         


Ser Val Ala Ser Lys Asp Val Ser Val Trp Cys Ser Asn Asp Tyr Leu 
        115                 120                 125             


Gly Met Ser Arg His Pro Gln Val Leu Gln Ala Thr Gln Glu Thr Leu 
    130                 135                 140                 


Gln Arg His Gly Ala Gly Ala Gly Gly Thr Arg Asn Ile Ser Gly Thr 
145                 150                 155                 160 


Ser Lys Phe His Val Glu Leu Glu Gln Glu Leu Ala Glu Leu His Gln 
                165                 170                 175     


Lys Asp Ser Ala Leu Leu Phe Ser Ser Cys Phe Val Ala Asn Asp Ser 
            180                 185                 190         


Thr Leu Phe Thr Leu Ala 
        195             


<210>  685
<211>  171
<212>  PRT
<213>  Homo Sapiens

<400>  685

Met Leu Ser Glu Leu Gln Asp Gly Lys Ser Lys Ile Val Gln Lys Ala 
1               5                   10                  15      


Ala Pro Glu Val Gln Glu Asp Val Lys Ala Phe Lys Thr Gly Asn Tyr 
            20                  25                  30          


Val Phe Ser Tyr Asp Gln Phe Phe Arg Asp Lys Ile Met Glu Lys Lys 
        35                  40                  45              


Gln Asp His Thr Tyr Arg Val Phe Lys Thr Val Asn Arg Trp Ala Asp 
    50                  55                  60                  


Ala Tyr Pro Phe Ala Gln His Phe Ser Glu Ala Ser Val Ala Ser Lys 
65                  70                  75                  80  


Asp Val Ser Val Trp Cys Ser Asn Asp Tyr Leu Gly Met Ser Arg His 
                85                  90                  95      


Pro Gln Val Leu Gln Ala Thr Gln Glu Thr Leu Gln Arg His Gly Ala 
            100                 105                 110         


Gly Ala Gly Gly Thr Arg Asn Ile Ser Gly Thr Ser Lys Phe His Val 
        115                 120                 125             


Glu Leu Glu Gln Glu Leu Ala Glu Leu His Gln Lys Asp Ser Ala Leu 
    130                 135                 140                 


Leu Phe Ser Ser Cys Phe Val Ala Asn Asp Ser Thr Leu Phe Thr Leu 
145                 150                 155                 160 


Ala Lys Ile Leu Pro Gly Cys Glu Ile Tyr Ser 
                165                 170     


<210>  686
<211>  165
<212>  PRT
<213>  Homo Sapiens

<400>  686

Met Arg Gly Gly Glu Val Ala Leu Gly Trp Asn Lys Lys Lys Arg Leu 
1               5                   10                  15      


Phe Cys Glu Asp Phe Arg Phe Lys Met Val Thr Ala Ala Met Leu Leu 
            20                  25                  30          


Gln Cys Cys Pro Val Leu Ala Arg Gly Pro Thr Ser Leu Leu Gly Lys 
        35                  40                  45              


Val Val Lys Thr His Gln Phe Leu Phe Gly Ile Gly Arg Cys Pro Ile 
    50                  55                  60                  


Leu Ala Thr Gln Gly Pro Asn Cys Ser Gln Ile His Leu Lys Ala Thr 
65                  70                  75                  80  


Lys Ala Gly Gly Asp Ser Pro Ser Trp Ala Lys Gly His Cys Pro Phe 
                85                  90                  95      


Met Leu Ser Glu Leu Gln Asp Gly Lys Ser Lys Ile Val Gln Lys Ala 
            100                 105                 110         


Ala Pro Glu Val Gln Glu Asp Val Lys Ala Phe Lys Thr Asp Leu Pro 
        115                 120                 125             


Ser Ser Leu Val Ser Val Ser Leu Arg Lys Pro Phe Ser Gly Pro Gln 
    130                 135                 140                 


Glu Gln Glu Gln Ile Ser Gly Lys Val Thr His Leu Ile Gln Asn Asn 
145                 150                 155                 160 


Met Pro Gly Asn Tyr 
                165 


<210>  687
<211>  574
<212>  PRT
<213>  Homo Sapiens

<400>  687

Met Arg Gly Gly Glu Val Ala Leu Gly Trp Asn Lys Lys Lys Arg Leu 
1               5                   10                  15      


Phe Cys Glu Asp Phe Arg Phe Lys Met Val Thr Ala Ala Met Leu Leu 
            20                  25                  30          


Gln Cys Cys Pro Val Leu Ala Arg Gly Pro Thr Ser Leu Leu Gly Lys 
        35                  40                  45              


Val Val Lys Thr His Gln Phe Leu Phe Gly Ile Gly Arg Cys Pro Ile 
    50                  55                  60                  


Leu Ala Thr Gln Gly Pro Asn Cys Ser Gln Ile His Leu Lys Ala Thr 
65                  70                  75                  80  


Lys Ala Gly Gly Asp Ser Pro Ser Trp Ala Lys Gly His Cys Pro Phe 
                85                  90                  95      


Met Leu Ser Glu Leu Gln Asp Gly Lys Ser Lys Ile Val Gln Lys Ala 
            100                 105                 110         


Ala Pro Glu Val Gln Glu Asp Val Lys Ala Phe Lys Thr Gly Asn Tyr 
        115                 120                 125             


Val Phe Ser Tyr Asp Gln Phe Phe Arg Asp Lys Ile Met Glu Lys Lys 
    130                 135                 140                 


Gln Asp His Thr Tyr Arg Val Phe Lys Thr Val Asn Arg Trp Ala Asp 
145                 150                 155                 160 


Ala Tyr Pro Phe Ala Gln His Phe Ser Glu Ala Ser Val Ala Ser Lys 
                165                 170                 175     


Asp Val Ser Val Trp Cys Ser Asn Asp Tyr Leu Gly Met Ser Arg His 
            180                 185                 190         


Pro Gln Val Leu Gln Ala Thr Gln Glu Thr Leu Gln Arg His Gly Ala 
        195                 200                 205             


Gly Ala Gly Gly Thr Arg Asn Ile Ser Gly Thr Ser Lys Phe His Val 
    210                 215                 220                 


Glu Leu Glu Gln Glu Leu Ala Glu Leu His Gln Lys Asp Ser Ala Leu 
225                 230                 235                 240 


Leu Phe Ser Ser Cys Phe Val Ala Asn Asp Ser Thr Leu Phe Thr Leu 
                245                 250                 255     


Ala Lys Ile Leu Pro Gly Cys Glu Ile Tyr Ser Asp Ala Gly Asn His 
            260                 265                 270         


Ala Ser Met Ile Gln Gly Ile Arg Asn Ser Gly Ala Ala Lys Phe Val 
        275                 280                 285             


Phe Arg His Asn Asp Pro Asp His Leu Lys Lys Leu Leu Glu Lys Ser 
    290                 295                 300                 


Asn Pro Lys Ile Pro Lys Ile Val Ala Phe Glu Thr Val His Ser Met 
305                 310                 315                 320 


Asp Gly Ala Ile Cys Pro Leu Glu Glu Leu Cys Asp Val Ser His Gln 
                325                 330                 335     


Tyr Gly Ala Leu Thr Phe Val Asp Glu Val His Ala Val Gly Leu Tyr 
            340                 345                 350         


Gly Ser Arg Gly Ala Gly Ile Gly Glu Arg Asp Gly Ile Met His Lys 
        355                 360                 365             


Ile Asp Ile Ile Ser Gly Thr Leu Gly Lys Ala Phe Gly Cys Val Gly 
    370                 375                 380                 


Gly Tyr Ile Ala Ser Thr Arg Asp Leu Val Asp Met Val Arg Ser Tyr 
385                 390                 395                 400 


Ala Ala Gly Phe Ile Phe Thr Thr Ser Leu Pro Pro Met Val Leu Ser 
                405                 410                 415     


Gly Ala Leu Glu Ser Val Arg Leu Leu Lys Gly Glu Glu Gly Gln Ala 
            420                 425                 430         


Leu Arg Arg Ala His Gln Arg Asn Val Lys His Met Arg Gln Leu Leu 
        435                 440                 445             


Met Asp Arg Gly Leu Pro Val Ile Pro Cys Pro Ser His Ile Ile Pro 
    450                 455                 460                 


Ile Arg Val Gly Asn Ala Ala Leu Asn Ser Lys Leu Cys Asp Leu Leu 
465                 470                 475                 480 


Leu Ser Lys His Gly Ile Tyr Val Gln Ala Ile Asn Tyr Pro Thr Val 
                485                 490                 495     


Pro Arg Gly Glu Glu Leu Leu Arg Leu Ala Pro Ser Pro His His Ser 
            500                 505                 510         


Pro Gln Met Met Glu Asp Phe Val Glu Lys Leu Leu Leu Ala Trp Thr 
        515                 520                 525             


Ala Val Gly Leu Pro Leu Gln Asp Val Ser Val Ala Ala Cys Asn Phe 
    530                 535                 540                 


Cys Arg Arg Pro Val His Phe Glu Leu Met Ser Glu Trp Glu Arg Ser 
545                 550                 555                 560 


Tyr Phe Gly Asn Met Gly Pro Gln Tyr Val Thr Thr Tyr Ala 
                565                 570                 


<210>  688
<211>  587
<212>  PRT
<213>  Homo Sapiens

<400>  688

Met Val Thr Ala Ala Met Leu Leu Gln Cys Cys Pro Val Leu Ala Arg 
1               5                   10                  15      


Gly Pro Thr Ser Leu Leu Gly Lys Val Val Lys Thr His Gln Phe Leu 
            20                  25                  30          


Phe Gly Ile Gly Arg Cys Pro Ile Leu Ala Thr Gln Gly Pro Asn Cys 
        35                  40                  45              


Ser Gln Ile His Leu Lys Ala Thr Lys Ala Gly Gly Asp Ser Pro Ser 
    50                  55                  60                  


Trp Ala Lys Gly His Cys Pro Phe Met Leu Ser Glu Leu Gln Asp Gly 
65                  70                  75                  80  


Lys Ser Lys Ile Val Gln Lys Ala Ala Pro Glu Val Gln Glu Asp Val 
                85                  90                  95      


Lys Ala Phe Lys Thr Asp Leu Pro Ser Ser Leu Val Ser Val Ser Leu 
            100                 105                 110         


Arg Lys Pro Phe Ser Gly Pro Gln Glu Gln Glu Gln Ile Ser Gly Lys 
        115                 120                 125             


Val Thr His Leu Ile Gln Asn Asn Met Pro Gly Asn Tyr Val Phe Ser 
    130                 135                 140                 


Tyr Asp Gln Phe Phe Arg Asp Lys Ile Met Glu Lys Lys Gln Asp His 
145                 150                 155                 160 


Thr Tyr Arg Val Phe Lys Thr Val Asn Arg Trp Ala Asp Ala Tyr Pro 
                165                 170                 175     


Phe Ala Gln His Phe Ser Glu Ala Ser Val Ala Ser Lys Asp Val Ser 
            180                 185                 190         


Val Trp Cys Ser Asn Asp Tyr Leu Gly Met Ser Arg His Pro Gln Val 
        195                 200                 205             


Leu Gln Ala Thr Gln Glu Thr Leu Gln Arg His Gly Ala Gly Ala Gly 
    210                 215                 220                 


Gly Thr Arg Asn Ile Ser Gly Thr Ser Lys Phe His Val Glu Leu Glu 
225                 230                 235                 240 


Gln Glu Leu Ala Glu Leu His Gln Lys Asp Ser Ala Leu Leu Phe Ser 
                245                 250                 255     


Ser Cys Phe Val Ala Asn Asp Ser Thr Leu Phe Thr Leu Ala Lys Ile 
            260                 265                 270         


Leu Pro Gly Cys Glu Ile Tyr Ser Asp Ala Gly Asn His Ala Ser Met 
        275                 280                 285             


Ile Gln Gly Ile Arg Asn Ser Gly Ala Ala Lys Phe Val Phe Arg His 
    290                 295                 300                 


Asn Asp Pro Asp His Leu Lys Lys Leu Leu Glu Lys Ser Asn Pro Lys 
305                 310                 315                 320 


Ile Pro Lys Ile Val Ala Phe Glu Thr Val His Ser Met Asp Gly Ala 
                325                 330                 335     


Ile Cys Pro Leu Glu Glu Leu Cys Asp Val Ser His Gln Tyr Gly Ala 
            340                 345                 350         


Leu Thr Phe Val Asp Glu Val His Ala Val Gly Leu Tyr Gly Ser Arg 
        355                 360                 365             


Gly Ala Gly Ile Gly Glu Arg Asp Gly Ile Met His Lys Ile Asp Ile 
    370                 375                 380                 


Ile Ser Gly Thr Leu Gly Lys Ala Phe Gly Cys Val Gly Gly Tyr Ile 
385                 390                 395                 400 


Ala Ser Thr Arg Asp Leu Val Asp Met Val Arg Ser Tyr Ala Ala Gly 
                405                 410                 415     


Phe Ile Phe Thr Thr Ser Leu Pro Pro Met Val Leu Ser Gly Ala Leu 
            420                 425                 430         


Glu Ser Val Arg Leu Leu Lys Gly Glu Glu Gly Gln Ala Leu Arg Arg 
        435                 440                 445             


Ala His Gln Arg Asn Val Lys His Met Arg Gln Leu Leu Met Asp Arg 
    450                 455                 460                 


Gly Leu Pro Val Ile Pro Cys Pro Ser His Ile Ile Pro Ile Arg Val 
465                 470                 475                 480 


Gly Asn Ala Ala Leu Asn Ser Lys Leu Cys Asp Leu Leu Leu Ser Lys 
                485                 490                 495     


His Gly Ile Tyr Val Gln Ala Ile Asn Tyr Pro Thr Val Pro Arg Gly 
            500                 505                 510         


Glu Glu Leu Leu Arg Leu Ala Pro Ser Pro His His Ser Pro Gln Met 
        515                 520                 525             


Met Glu Asp Phe Val Glu Lys Leu Leu Leu Ala Trp Thr Ala Val Gly 
    530                 535                 540                 


Leu Pro Leu Gln Asp Val Ser Val Ala Ala Cys Asn Phe Cys Arg Arg 
545                 550                 555                 560 


Pro Val His Phe Glu Leu Met Ser Glu Trp Glu Arg Ser Tyr Phe Gly 
                565                 570                 575     


Asn Met Gly Pro Gln Tyr Val Thr Thr Tyr Ala 
            580                 585         


<210>  689
<211>  550
<212>  PRT
<213>  Homo Sapiens

<400>  689

Met Val Thr Ala Ala Met Leu Leu Gln Cys Cys Pro Val Leu Ala Arg 
1               5                   10                  15      


Gly Pro Thr Ser Leu Leu Gly Lys Val Val Lys Thr His Gln Phe Leu 
            20                  25                  30          


Phe Gly Ile Gly Arg Cys Pro Ile Leu Ala Thr Gln Gly Pro Asn Cys 
        35                  40                  45              


Ser Gln Ile His Leu Lys Ala Thr Lys Ala Gly Gly Asp Ser Pro Ser 
    50                  55                  60                  


Trp Ala Lys Gly His Cys Pro Phe Met Leu Ser Glu Leu Gln Asp Gly 
65                  70                  75                  80  


Lys Ser Lys Ile Val Gln Lys Ala Ala Pro Glu Val Gln Glu Asp Val 
                85                  90                  95      


Lys Ala Phe Lys Thr Gly Asn Tyr Val Phe Ser Tyr Asp Gln Phe Phe 
            100                 105                 110         


Arg Asp Lys Ile Met Glu Lys Lys Gln Asp His Thr Tyr Arg Val Phe 
        115                 120                 125             


Lys Thr Val Asn Arg Trp Ala Asp Ala Tyr Pro Phe Ala Gln His Phe 
    130                 135                 140                 


Ser Glu Ala Ser Val Ala Ser Lys Asp Val Ser Val Trp Cys Ser Asn 
145                 150                 155                 160 


Asp Tyr Leu Gly Met Ser Arg His Pro Gln Val Leu Gln Ala Thr Gln 
                165                 170                 175     


Glu Thr Leu Gln Arg His Gly Ala Gly Ala Gly Gly Thr Arg Asn Ile 
            180                 185                 190         


Ser Gly Thr Ser Lys Phe His Val Glu Leu Glu Gln Glu Leu Ala Glu 
        195                 200                 205             


Leu His Gln Lys Asp Ser Ala Leu Leu Phe Ser Ser Cys Phe Val Ala 
    210                 215                 220                 


Asn Asp Ser Thr Leu Phe Thr Leu Ala Lys Ile Leu Pro Gly Cys Glu 
225                 230                 235                 240 


Ile Tyr Ser Asp Ala Gly Asn His Ala Ser Met Ile Gln Gly Ile Arg 
                245                 250                 255     


Asn Ser Gly Ala Ala Lys Phe Val Phe Arg His Asn Asp Pro Asp His 
            260                 265                 270         


Leu Lys Lys Leu Leu Glu Lys Ser Asn Pro Lys Ile Pro Lys Ile Val 
        275                 280                 285             


Ala Phe Glu Thr Val His Ser Met Asp Gly Ala Ile Cys Pro Leu Glu 
    290                 295                 300                 


Glu Leu Cys Asp Val Ser His Gln Tyr Gly Ala Leu Thr Phe Val Asp 
305                 310                 315                 320 


Glu Val His Ala Val Gly Leu Tyr Gly Ser Arg Gly Ala Gly Ile Gly 
                325                 330                 335     


Glu Arg Asp Gly Ile Met His Lys Ile Asp Ile Ile Ser Gly Thr Leu 
            340                 345                 350         


Gly Lys Ala Phe Gly Cys Val Gly Gly Tyr Ile Ala Ser Thr Arg Asp 
        355                 360                 365             


Leu Val Asp Met Val Arg Ser Tyr Ala Ala Gly Phe Ile Phe Thr Thr 
    370                 375                 380                 


Ser Leu Pro Pro Met Val Leu Ser Gly Ala Leu Glu Ser Val Arg Leu 
385                 390                 395                 400 


Leu Lys Gly Glu Glu Gly Gln Ala Leu Arg Arg Ala His Gln Arg Asn 
                405                 410                 415     


Val Lys His Met Arg Gln Leu Leu Met Asp Arg Gly Leu Pro Val Ile 
            420                 425                 430         


Pro Cys Pro Ser His Ile Ile Pro Ile Arg Val Gly Asn Ala Ala Leu 
        435                 440                 445             


Asn Ser Lys Leu Cys Asp Leu Leu Leu Ser Lys His Gly Ile Tyr Val 
    450                 455                 460                 


Gln Ala Ile Asn Tyr Pro Thr Val Pro Arg Gly Glu Glu Leu Leu Arg 
465                 470                 475                 480 


Leu Ala Pro Ser Pro His His Ser Pro Gln Met Met Glu Asp Phe Val 
                485                 490                 495     


Glu Lys Leu Leu Leu Ala Trp Thr Ala Val Gly Leu Pro Leu Gln Asp 
            500                 505                 510         


Val Ser Val Ala Ala Cys Asn Phe Cys Arg Arg Pro Val His Phe Glu 
        515                 520                 525             


Leu Met Ser Glu Trp Glu Arg Ser Tyr Phe Gly Asn Met Gly Pro Gln 
    530                 535                 540                 


Tyr Val Thr Thr Tyr Ala 
545                 550 


<210>  690
<211>  141
<212>  PRT
<213>  Homo Sapiens

<400>  690

Met Val Thr Ala Ala Met Leu Leu Gln Cys Cys Pro Val Leu Ala Arg 
1               5                   10                  15      


Gly Pro Thr Ser Leu Leu Gly Lys Val Val Lys Thr His Gln Phe Leu 
            20                  25                  30          


Phe Gly Ile Gly Arg Cys Pro Ile Leu Ala Thr Gln Gly Pro Asn Cys 
        35                  40                  45              


Ser Gln Ile His Leu Lys Ala Thr Lys Ala Gly Gly Asp Ser Pro Ser 
    50                  55                  60                  


Trp Ala Lys Gly His Cys Pro Phe Met Leu Ser Glu Leu Gln Asp Gly 
65                  70                  75                  80  


Lys Ser Lys Ile Val Gln Lys Ala Ala Pro Glu Val Gln Glu Asp Val 
                85                  90                  95      


Lys Ala Phe Lys Thr Gly Arg Pro Cys Ser Val Met Val Leu Glu Leu 
            100                 105                 110         


Val Ala Pro Ala Thr Ser Gln Ala Pro Ile Leu Pro Gly Cys Glu Ile 
        115                 120                 125             


Tyr Ser Asp Ala Gly Asn His Ala Ser Met Ile Gln Gly 
    130                 135                 140     


<210>  691
<211>  276
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  691

Xaa Glu Leu Glu Gln Glu Leu Ala Glu Leu His Gln Lys Asp Ser Ala 
1               5                   10                  15      


Leu Leu Phe Ser Ser Cys Phe Val Ala Asn Asp Ser Thr Leu Phe Thr 
            20                  25                  30          


Leu Ala Lys Ile Leu Pro Gly Cys Glu Ile Tyr Ser Asp Ala Gly Asn 
        35                  40                  45              


His Ala Ser Met Ile Gln Gly Ile Arg Asn Ser Gly Ala Ala Lys Phe 
    50                  55                  60                  


Val Phe Arg His Asn Asp Pro Asp His Leu Lys Lys Leu Leu Glu Lys 
65                  70                  75                  80  


Ser Asn Pro Lys Ile Pro Lys Ile Val Ala Phe Glu Thr Val His Ser 
                85                  90                  95      


Met Asp Gly Ala Ile Cys Pro Leu Glu Glu Leu Cys Asp Val Ser His 
            100                 105                 110         


Gln Tyr Gly Ala Leu Thr Phe Val Asp Glu Val His Ala Val Gly Leu 
        115                 120                 125             


Tyr Gly Ser Arg Gly Ala Gly Ile Gly Glu Arg Asp Gly Ile Met His 
    130                 135                 140                 


Lys Ile Asp Ile Ile Ser Gly Thr Leu Gly Lys Ala Phe Gly Cys Val 
145                 150                 155                 160 


Gly Gly Tyr Ile Ala Ser Thr Arg Asp Leu Val Asp Met Val Arg Ser 
                165                 170                 175     


Tyr Ala Ala Gly Phe Ile Phe Thr Thr Ser Leu Pro Pro Met Val Leu 
            180                 185                 190         


Ser Gly Ala Leu Glu Ser Val Arg Leu Leu Lys Gly Glu Glu Gly Gln 
        195                 200                 205             


Ala Leu Arg Arg Ala His Gln Arg Asn Val Lys His Met Arg Gln Leu 
    210                 215                 220                 


Leu Met Asp Arg Gly Leu Pro Val Ile Pro Cys Pro Ser His Ile Ile 
225                 230                 235                 240 


Pro Ile Arg Arg Ser Cys Cys Trp Leu Gly Leu Arg Trp Gly Cys Pro 
                245                 250                 255     


Ser Arg Met Cys Leu Trp Leu Pro Ala Ile Ser Val Ala Val Leu Tyr 
            260                 265                 270         


Thr Leu Ser Ser 
        275     


<210>  692
<211>  197
<212>  PRT
<213>  Homo Sapiens

<400>  692

Gly Phe Glu Trp Gly Gly Gln Arg Arg Ala Ser His Asn Ser Thr Phe 
1               5                   10                  15      


Ser Ala Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu 
            20                  25                  30          


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
        35                  40                  45              


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp 
    50                  55                  60                  


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
65                  70                  75                  80  


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
                85                  90                  95      


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
            100                 105                 110         


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
        115                 120                 125             


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
    130                 135                 140                 


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
145                 150                 155                 160 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
                165                 170                 175     


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
            180                 185                 190         


Glu Cys Cys Gln Ala 
        195         


<210>  693
<211>  417
<212>  PRT
<213>  Homo Sapiens

<400>  693

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala 
            20                  25                  30          


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Ala Val 
        35                  40                  45              


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
    50                  55                  60                  


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
65                  70                  75                  80  


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
                85                  90                  95      


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
            100                 105                 110         


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
        115                 120                 125             


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
    130                 135                 140                 


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
145                 150                 155                 160 


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
                165                 170                 175     


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
            180                 185                 190         


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
        195                 200                 205             


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
    210                 215                 220                 


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
225                 230                 235                 240 


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
                245                 250                 255     


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
            260                 265                 270         


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
        275                 280                 285             


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
    290                 295                 300                 


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
305                 310                 315                 320 


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
                325                 330                 335     


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
            340                 345                 350         


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
        355                 360                 365             


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
    370                 375                 380                 


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
385                 390                 395                 400 


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
                405                 410                 415     


Leu 
    


<210>  694
<211>  609
<212>  PRT
<213>  Homo Sapiens

<400>  694

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala 
            20                  25                  30          


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
    50                  55                  60                  


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
65                  70                  75                  80  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
                85                  90                  95      


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
            100                 105                 110         


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
        115                 120                 125             


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
    130                 135                 140                 


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
145                 150                 155                 160 


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
                165                 170                 175     


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
            180                 185                 190         


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
        195                 200                 205             


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
    210                 215                 220                 


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
225                 230                 235                 240 


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
                245                 250                 255     


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
            260                 265                 270         


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
        275                 280                 285             


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
    290                 295                 300                 


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
305                 310                 315                 320 


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
                325                 330                 335     


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
            340                 345                 350         


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
        355                 360                 365             


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
    370                 375                 380                 


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
385                 390                 395                 400 


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
                405                 410                 415     


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
            420                 425                 430         


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
        435                 440                 445             


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
    450                 455                 460                 


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
465                 470                 475                 480 


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
                485                 490                 495     


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
        515                 520                 525             


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
    530                 535                 540                 


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
545                 550                 555                 560 


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
                565                 570                 575     


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
        595                 600                 605             


Leu 
    


<210>  695
<211>  604
<212>  PRT
<213>  Homo Sapiens

<400>  695

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala 
            20                  25                  30          


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
    50                  55                  60                  


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
65                  70                  75                  80  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
                85                  90                  95      


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
            100                 105                 110         


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
        115                 120                 125             


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
    130                 135                 140                 


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
145                 150                 155                 160 


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
                165                 170                 175     


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
            180                 185                 190         


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
        195                 200                 205             


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
    210                 215                 220                 


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
225                 230                 235                 240 


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
                245                 250                 255     


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
            260                 265                 270         


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
        275                 280                 285             


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
    290                 295                 300                 


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
305                 310                 315                 320 


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
                325                 330                 335     


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
            340                 345                 350         


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
        355                 360                 365             


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
    370                 375                 380                 


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
385                 390                 395                 400 


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
                405                 410                 415     


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
            420                 425                 430         


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
        435                 440                 445             


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
    450                 455                 460                 


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
465                 470                 475                 480 


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
                485                 490                 495     


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
        515                 520                 525             


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
    530                 535                 540                 


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
545                 550                 555                 560 


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
                565                 570                 575     


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
            580                 585                 590         


Ala Glu Glu Pro Thr Met Arg Ile Arg Glu Arg Lys 
        595                 600                 


<210>  696
<211>  396
<212>  PRT
<213>  Homo Sapiens

<400>  696

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala 
            20                  25                  30          


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
    50                  55                  60                  


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
65                  70                  75                  80  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
                85                  90                  95      


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
            100                 105                 110         


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
        115                 120                 125             


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
    130                 135                 140                 


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
145                 150                 155                 160 


Lys Tyr Leu Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp 
                165                 170                 175     


Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val 
            180                 185                 190         


Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln 
        195                 200                 205             


Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys 
    210                 215                 220                 


Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn 
225                 230                 235                 240 


Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg 
                245                 250                 255     


Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys 
            260                 265                 270         


Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys 
        275                 280                 285             


Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val 
    290                 295                 300                 


Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe 
305                 310                 315                 320 


His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys 
                325                 330                 335     


Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys 
            340                 345                 350         


Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys 
        355                 360                 365             


Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys 
    370                 375                 380                 


Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
385                 390                 395     


<210>  697
<211>  396
<212>  PRT
<213>  Homo Sapiens

<400>  697

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala 
            20                  25                  30          


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
    50                  55                  60                  


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
65                  70                  75                  80  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
                85                  90                  95      


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
            100                 105                 110         


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
        115                 120                 125             


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
    130                 135                 140                 


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
145                 150                 155                 160 


Lys Tyr Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp 
                165                 170                 175     


Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val 
            180                 185                 190         


Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln 
        195                 200                 205             


Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys 
    210                 215                 220                 


Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn 
225                 230                 235                 240 


Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg 
                245                 250                 255     


Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys 
            260                 265                 270         


Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys 
        275                 280                 285             


Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val 
    290                 295                 300                 


Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe 
305                 310                 315                 320 


His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys 
                325                 330                 335     


Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys 
            340                 345                 350         


Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys 
        355                 360                 365             


Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys 
    370                 375                 380                 


Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
385                 390                 395     


<210>  698
<211>  494
<212>  PRT
<213>  Homo Sapiens

<400>  698

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala 
            20                  25                  30          


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Tyr Leu 
        35                  40                  45              


Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu 
    50                  55                  60                  


Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala 
65                  70                  75                  80  


Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp 
                85                  90                  95      


Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu 
            100                 105                 110         


Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu 
        115                 120                 125             


Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val 
    130                 135                 140                 


Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu 
145                 150                 155                 160 


Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn 
                165                 170                 175     


Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu 
            180                 185                 190         


Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro 
        195                 200                 205             


Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val 
    210                 215                 220                 


Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu 
225                 230                 235                 240 


Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu 
                245                 250                 255     


Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala 
            260                 265                 270         


Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro 
        275                 280                 285             


Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe 
    290                 295                 300                 


Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr 
305                 310                 315                 320 


Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser 
                325                 330                 335     


Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala 
            340                 345                 350         


Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln 
        355                 360                 365             


Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys 
    370                 375                 380                 


Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu 
385                 390                 395                 400 


Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe 
                405                 410                 415     


Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile 
            420                 425                 430         


Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala 
        435                 440                 445             


Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val 
    450                 455                 460                 


Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu 
465                 470                 475                 480 


Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
                485                 490                 


<210>  699
<211>  105
<212>  PRT
<213>  Homo Sapiens

<400>  699

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Thr Tyr Met Lys Leu 
            20                  25                  30          


Pro Glu Asp Ile Leu Thr Phe Met Pro Arg Asn Ser Phe Ser Leu Leu 
        35                  40                  45              


Lys Gly Ile Lys Leu Leu Leu Gln Asn Val Ala Lys Leu Leu Ile Lys 
    50                  55                  60                  


Leu Pro Ala Cys Cys Gln Ser Ser Met Asn Phe Gly Met Lys Gly Arg 
65                  70                  75                  80  


Leu Arg Leu Pro Asn Arg Asp Ser Ser Val Pro Val Ser Lys Asn Leu 
                85                  90                  95      


Glu Lys Glu Leu Ser Lys His Gly Gln 
            100                 105 


<210>  700
<211>  459
<212>  PRT
<213>  Homo Sapiens

<400>  700

Met Ser Gln Leu Lys Ile Val Thr Asn His Leu Tyr Leu Tyr Glu Ile 
1               5                   10                  15      


Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala 
            20                  25                  30          


Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys 
        35                  40                  45              


Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys 
    50                  55                  60                  


Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe 
65                  70                  75                  80  


Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg 
                85                  90                  95      


Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu 
            100                 105                 110         


Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala 
        115                 120                 125             


Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser 
    130                 135                 140                 


Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys 
145                 150                 155                 160 


Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu 
                165                 170                 175     


Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn 
            180                 185                 190         


Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr 
        195                 200                 205             


Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala 
    210                 215                 220                 


Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro 
225                 230                 235                 240 


His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu 
                245                 250                 255     


Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu 
            260                 265                 270         


Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys 
        275                 280                 285             


Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu 
    290                 295                 300                 


Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met 
305                 310                 315                 320 


Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val 
                325                 330                 335     


Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr 
            340                 345                 350         


Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp 
        355                 360                 365             


Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His 
    370                 375                 380                 


Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln 
385                 390                 395                 400 


Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu 
                405                 410                 415     


Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys 
            420                 425                 430         


Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys 
        435                 440                 445             


Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
    450                 455                 


<210>  701
<211>  454
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  701

Xaa Phe Ser Lys Phe Arg Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro 
1               5                   10                  15      


Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala 
            20                  25                  30          


Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu 
        35                  40                  45              


Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys 
    50                  55                  60                  


Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe 
65                  70                  75                  80  


Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu 
                85                  90                  95      


Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr 
            100                 105                 110         


Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp 
        115                 120                 125             


Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu 
    130                 135                 140                 


Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala 
145                 150                 155                 160 


Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala 
                165                 170                 175     


Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys 
            180                 185                 190         


Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro 
        195                 200                 205             


Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr 
    210                 215                 220                 


Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala 
225                 230                 235                 240 


Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu 
                245                 250                 255     


Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe 
            260                 265                 270         


Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser 
        275                 280                 285             


Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser 
    290                 295                 300                 


Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp 
305                 310                 315                 320 


Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr 
                325                 330                 335     


Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn 
            340                 345                 350         


Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro 
        355                 360                 365             


Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr 
    370                 375                 380                 


Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu 
385                 390                 395                 400 


Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val 
                405                 410                 415     


Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp 
            420                 425                 430         


Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser 
        435                 440                 445             


Gln Ala Ala Leu Gly Leu 
    450                 


<210>  702
<211>  518
<212>  PRT
<213>  Homo Sapiens

<400>  702

Met Phe Leu Arg Ala Gly Leu Ala Ala Leu Ser Pro Leu Leu Arg Ser 
1               5                   10                  15      


Leu Arg Pro Ser Pro Val Ala Ala Met Ser Thr Gly Thr Phe Val Val 
            20                  25                  30          


Ser Gln Pro Leu Asn Tyr Arg Gly Gly Ala Arg Val Glu Pro Ala Asp 
        35                  40                  45              


Ala Ser Gly Thr Glu Lys Ala Phe Glu Pro Ala Thr Gly Arg Val Ile 
    50                  55                  60                  


Ala Thr Phe Thr Cys Ser Gly Glu Lys Glu Val Asn Leu Ala Val Gln 
65                  70                  75                  80  


Asn Ala Lys Ala Ala Phe Lys Ile Trp Ser Gln Lys Ser Gly Met Glu 
                85                  90                  95      


Arg Cys Arg Ile Leu Leu Glu Ala Ala Arg Ile Ile Arg Glu Arg Glu 
            100                 105                 110         


Asp Glu Ile Ala Thr Met Glu Cys Ile Asn Asn Gly Lys Ser Ile Phe 
        115                 120                 125             


Glu Ala Arg Leu Asp Ile Asp Ile Ser Trp Gln Cys Leu Glu Tyr Tyr 
    130                 135                 140                 


Ala Gly Leu Ala Ala Ser Met Ala Gly Glu His Ile Gln Leu Pro Gly 
145                 150                 155                 160 


Gly Ser Phe Gly Tyr Thr Arg Arg Glu Pro Leu Gly Val Cys Val Gly 
                165                 170                 175     


Ile Gly Ala Trp Asn Tyr Pro Phe Gln Ile Ala Ser Trp Lys Ser Ala 
            180                 185                 190         


Pro Ala Leu Ala Cys Gly Asn Ala Met Val Phe Lys Pro Ser Pro Phe 
        195                 200                 205             


Thr Pro Val Ser Ala Leu Leu Leu Ala Glu Ile Tyr Ser Glu Ala Gly 
    210                 215                 220                 


Val Pro Pro Gly Leu Phe Asn Val Val Gln Gly Gly Ala Ala Thr Gly 
225                 230                 235                 240 


Gln Phe Leu Cys Gln His Pro Asp Val Ala Lys Val Ser Phe Thr Gly 
                245                 250                 255     


Ser Val Pro Thr Gly Met Lys Ile Met Glu Met Ser Ala Lys Gly Ile 
            260                 265                 270         


Lys Pro Val Thr Leu Glu Leu Gly Gly Lys Ser Pro Leu Ile Ile Phe 
        275                 280                 285             


Ser Asp Cys Asp Met Asn Asn Ala Val Lys Gly Ala Leu Met Ala Asn 
    290                 295                 300                 


Phe Leu Thr Gln Gly Gln Val Cys Cys Asn Gly Thr Arg Val Phe Val 
305                 310                 315                 320 


Gln Lys Glu Ile Leu Asp Lys Phe Thr Glu Glu Val Val Lys Gln Thr 
                325                 330                 335     


Gln Arg Ile Lys Ile Gly Asp Pro Leu Leu Glu Asp Thr Arg Met Gly 
            340                 345                 350         


Pro Leu Ile Asn Arg Pro His Leu Glu Arg Val Leu Gly Phe Val Lys 
        355                 360                 365             


Val Ala Lys Glu Gln Gly Ala Lys Val Leu Cys Gly Gly Asp Ile Tyr 
    370                 375                 380                 


Val Pro Glu Asp Pro Lys Leu Lys Asp Gly Tyr Tyr Met Arg Pro Cys 
385                 390                 395                 400 


Val Leu Thr Asn Cys Arg Asp Asp Met Thr Cys Val Lys Glu Glu Ile 
                405                 410                 415     


Phe Gly Pro Val Met Ser Ile Leu Ser Phe Asp Thr Glu Ala Glu Val 
            420                 425                 430         


Leu Glu Arg Ala Asn Asp Thr Thr Phe Gly Leu Ala Ala Gly Val Phe 
        435                 440                 445             


Thr Arg Asp Ile Gln Arg Ala His Arg Val Val Ala Glu Leu Gln Ala 
    450                 455                 460                 


Gly Thr Cys Phe Ile Asn Asn Tyr Asn Val Ser Pro Val Glu Leu Pro 
465                 470                 475                 480 


Phe Gly Gly Tyr Lys Lys Ser Gly Phe Gly Arg Glu Asn Gly Arg Val 
                485                 490                 495     


Thr Ile Glu Tyr Tyr Ser Gln Leu Lys Thr Val Cys Val Glu Met Gly 
            500                 505                 510         


Asp Val Glu Ser Ala Phe 
        515             


<210>  703
<211>  418
<212>  PRT
<213>  Homo Sapiens

<400>  703

Met Ala Arg Arg Lys Pro Glu Gly Ser Ser Phe Asn Met Thr His Leu 
1               5                   10                  15      


Ser Met Ala Met Ala Phe Ser Phe Pro Pro Val Ala Ser Gly Gln Leu 
            20                  25                  30          


His Pro Gln Leu Gly Asn Thr Gln His Gln Thr Glu Leu Gly Lys Glu 
        35                  40                  45              


Leu Ala Thr Thr Ser Thr Met Pro Tyr Gln Tyr Pro Ala Leu Thr Pro 
    50                  55                  60                  


Glu Gln Lys Lys Glu Leu Ser Asp Ile Ala His Arg Ile Val Ala Pro 
65                  70                  75                  80  


Gly Lys Gly Ile Leu Ala Ala Asp Glu Ser Thr Gly Ser Ile Ala Lys 
                85                  90                  95      


Arg Leu Gln Ser Ile Gly Thr Glu Asn Thr Glu Glu Asn Arg Arg Phe 
            100                 105                 110         


Tyr Arg Gln Leu Leu Leu Thr Ala Asp Asp Arg Val Asn Pro Cys Ile 
        115                 120                 125             


Gly Gly Val Ile Leu Phe His Glu Thr Leu Tyr Gln Lys Ala Asp Asp 
    130                 135                 140                 


Gly Arg Pro Phe Pro Gln Val Ile Lys Ser Lys Gly Gly Val Val Gly 
145                 150                 155                 160 


Ile Lys Val Asp Lys Gly Val Val Pro Leu Ala Gly Thr Asn Gly Glu 
                165                 170                 175     


Thr Thr Thr Gln Gly Leu Asp Gly Leu Ser Glu Arg Cys Ala Gln Tyr 
            180                 185                 190         


Lys Lys Asp Gly Ala Asp Phe Ala Lys Trp Arg Cys Val Leu Lys Ile 
        195                 200                 205             


Gly Glu His Thr Pro Ser Ala Leu Ala Ile Met Glu Asn Ala Asn Val 
    210                 215                 220                 


Leu Ala Arg Tyr Ala Ser Ile Cys Gln Gln Asn Gly Ile Val Pro Ile 
225                 230                 235                 240 


Val Glu Pro Glu Ile Leu Pro Asp Gly Asp His Asp Leu Lys Arg Cys 
                245                 250                 255     


Gln Tyr Val Thr Glu Lys Val Leu Ala Ala Val Tyr Lys Ala Leu Ser 
            260                 265                 270         


Asp His His Ile Tyr Leu Glu Gly Thr Leu Leu Lys Pro Asn Met Val 
        275                 280                 285             


Thr Pro Gly His Ala Cys Thr Gln Lys Phe Ser His Glu Glu Ile Ala 
    290                 295                 300                 


Met Ala Thr Val Thr Ala Leu Arg Arg Thr Val Pro Pro Ala Val Thr 
305                 310                 315                 320 


Gly Ile Thr Phe Leu Ser Gly Gly Gln Ser Glu Glu Glu Ala Ser Ile 
                325                 330                 335     


Asn Leu Asn Ala Ile Asn Lys Cys Pro Leu Leu Lys Pro Trp Ala Leu 
            340                 345                 350         


Thr Phe Ser Tyr Gly Arg Ala Leu Gln Ala Ser Ala Leu Lys Ala Trp 
        355                 360                 365             


Gly Gly Lys Lys Glu Asn Leu Lys Ala Ala Gln Glu Glu Tyr Val Lys 
    370                 375                 380                 


Arg Ala Leu Ala Asn Ser Leu Ala Cys Gln Gly Lys Tyr Thr Pro Ser 
385                 390                 395                 400 


Gly Gln Ala Gly Ala Ala Ala Ser Glu Ser Leu Phe Val Ser Asn His 
                405                 410                 415     


Ala Tyr 
        


<210>  704
<211>  278
<212>  PRT
<213>  Homo Sapiens

<400>  704

Met Ala Arg Arg Lys Pro Glu Gly Ser Ser Phe Asn Met Thr His Leu 
1               5                   10                  15      


Ser Met Ala Met Ala Phe Ser Phe Pro Pro Val Ala Ser Gly Gln Leu 
            20                  25                  30          


His Pro Gln Leu Gly Asn Thr Gln His Gln Thr Glu Leu Gly Lys Glu 
        35                  40                  45              


Leu Ala Thr Thr Ser Thr Met Pro Tyr Gln Tyr Pro Ala Leu Thr Pro 
    50                  55                  60                  


Glu Gln Lys Lys Glu Leu Ser Asp Ile Ala His Arg Ile Val Ala Pro 
65                  70                  75                  80  


Gly Lys Gly Ile Leu Ala Ala Asp Glu Ser Thr Gly Ser Ile Ala Lys 
                85                  90                  95      


Arg Leu Gln Ser Ile Gly Thr Glu Asn Thr Glu Glu Asn Arg Arg Phe 
            100                 105                 110         


Tyr Arg Gln Leu Leu Leu Thr Ala Asp Asp Arg Val Asn Pro Cys Ile 
        115                 120                 125             


Gly Gly Val Ile Leu Phe His Glu Thr Leu Tyr Gln Lys Ala Asp Asp 
    130                 135                 140                 


Gly Arg Pro Phe Pro Gln Val Ile Lys Ser Lys Gly Gly Val Val Gly 
145                 150                 155                 160 


Ile Lys Val Asp Lys Gly Val Val Pro Leu Ala Gly Thr Asn Gly Glu 
                165                 170                 175     


Thr Thr Thr Gln Gly Leu Asp Gly Leu Ser Glu Arg Cys Ala Gln Tyr 
            180                 185                 190         


Lys Lys Asp Gly Ala Asp Phe Ala Lys Trp Arg Cys Val Leu Lys Ile 
        195                 200                 205             


Gly Glu His Thr Pro Ser Ala Leu Ala Ile Met Glu Asn Ala Asn Val 
    210                 215                 220                 


Leu Ala Arg Tyr Ala Ser Ile Cys Gln Gln Asn Gly Ile Val Pro Ile 
225                 230                 235                 240 


Val Glu Pro Glu Ile Leu Pro Asp Gly Asp His Asp Leu Lys Arg Cys 
                245                 250                 255     


Gln Tyr Val Thr Glu Lys Val Leu Ala Ala Val Tyr Lys Ala Leu Ser 
            260                 265                 270         


Asp His His Ile Tyr Leu 
        275             


<210>  705
<211>  418
<212>  PRT
<213>  Homo Sapiens

<400>  705

Met Ala Arg Arg Lys Pro Glu Gly Ser Ser Phe Asn Met Thr His Leu 
1               5                   10                  15      


Ser Met Ala Met Ala Phe Ser Phe Pro Pro Val Ala Ser Gly Gln Leu 
            20                  25                  30          


His Pro Gln Leu Gly Asn Thr Gln His Gln Thr Glu Leu Gly Lys Glu 
        35                  40                  45              


Leu Ala Thr Thr Ser Thr Met Pro Tyr Gln Tyr Pro Ala Leu Thr Pro 
    50                  55                  60                  


Glu Gln Lys Lys Glu Leu Ser Asp Ile Ala His Arg Ile Val Ala Pro 
65                  70                  75                  80  


Gly Lys Gly Ile Leu Ala Ala Asp Glu Ser Thr Gly Ser Ile Ala Lys 
                85                  90                  95      


Arg Leu Gln Ser Ile Gly Thr Glu Asn Thr Glu Glu Asn Arg Arg Phe 
            100                 105                 110         


Tyr Arg Gln Leu Leu Leu Thr Ala Asp Asp Arg Val Asn Pro Cys Ile 
        115                 120                 125             


Gly Gly Val Ile Leu Phe His Glu Thr Leu Tyr Gln Lys Ala Asp Asp 
    130                 135                 140                 


Gly Arg Pro Phe Pro Gln Val Ile Lys Ser Lys Gly Gly Val Val Gly 
145                 150                 155                 160 


Ile Lys Val Asp Lys Gly Val Val Pro Leu Ala Gly Thr Asn Gly Glu 
                165                 170                 175     


Thr Thr Thr Gln Gly Leu Asp Gly Leu Ser Glu Arg Cys Ala Gln Tyr 
            180                 185                 190         


Lys Lys Asp Gly Ala Asp Phe Ala Lys Trp Arg Cys Val Leu Lys Ile 
        195                 200                 205             


Gly Glu His Thr Pro Ser Ala Leu Ala Ile Met Glu Asn Ala Asn Val 
    210                 215                 220                 


Leu Ala Arg Tyr Ala Ser Ile Cys Gln Gln Asn Gly Ile Val Pro Ile 
225                 230                 235                 240 


Val Glu Pro Glu Ile Leu Pro Asp Gly Asp His Asp Leu Lys Arg Cys 
                245                 250                 255     


Gln Tyr Val Thr Glu Lys Val Leu Ala Ala Val Tyr Lys Ala Leu Ser 
            260                 265                 270         


Asp His His Ile Tyr Leu Glu Gly Thr Leu Leu Lys Pro Asn Met Val 
        275                 280                 285             


Thr Pro Gly His Ala Cys Thr Gln Lys Phe Ser His Glu Glu Ile Ala 
    290                 295                 300                 


Met Ala Thr Val Thr Ala Leu Arg Arg Thr Val Pro Pro Ala Val Thr 
305                 310                 315                 320 


Gly Ile Thr Phe Leu Ser Gly Gly Gln Ser Glu Glu Glu Ala Ser Ile 
                325                 330                 335     


Asn Leu Asn Ala Ile Asn Lys Cys Pro Leu Leu Lys Pro Trp Ala Leu 
            340                 345                 350         


Thr Phe Ser Tyr Gly Arg Ala Leu Gln Ala Ser Ala Leu Lys Ala Trp 
        355                 360                 365             


Gly Gly Lys Lys Glu Asn Leu Lys Ala Ala Gln Glu Glu Tyr Val Lys 
    370                 375                 380                 


Arg Ala Leu Ala Asn Ser Leu Ala Cys Gln Gly Lys Tyr Thr Pro Ser 
385                 390                 395                 400 


Gly Gln Ala Gly Ala Ala Ala Ser Glu Ser Leu Phe Val Ser Asn His 
                405                 410                 415     


Ala Tyr 
        


<210>  706
<211>  155
<212>  PRT
<213>  Homo Sapiens

<400>  706

Met Pro Tyr Gln Tyr Pro Ala Leu Thr Pro Glu Gln Lys Lys Glu Leu 
1               5                   10                  15      


Ser Asp Ile Ala His Arg Ile Val Ala Pro Gly Lys Gly Ile Leu Ala 
            20                  25                  30          


Ala Asp Glu Ser Thr Gly Ser Ile Ala Lys Arg Leu Gln Ser Ile Gly 
        35                  40                  45              


Thr Glu Asn Thr Glu Glu Asn Arg Arg Phe Tyr Arg Gln Leu Leu Leu 
    50                  55                  60                  


Thr Ala Asp Asp Arg Val Asn Pro Cys Ile Gly Gly Val Ile Leu Phe 
65                  70                  75                  80  


His Glu Thr Leu Tyr Gln Lys Ala Asp Asp Gly Arg Pro Phe Pro Gln 
                85                  90                  95      


Val Ile Lys Ser Lys Gly Gly Val Val Gly Ile Lys Val Asp Lys Gly 
            100                 105                 110         


Val Val Pro Leu Ala Gly Thr Asn Gly Glu Thr Thr Thr Gln Gly Leu 
        115                 120                 125             


Asp Gly Leu Ser Glu Arg Cys Ala Gln Tyr Lys Lys Asp Gly Ala Asp 
    130                 135                 140                 


Phe Ala Lys Trp Arg Cys Val Leu Lys Ile Gly 
145                 150                 155 


<210>  707
<211>  364
<212>  PRT
<213>  Homo Sapiens

<400>  707

Met Pro Tyr Gln Tyr Pro Ala Leu Thr Pro Glu Gln Lys Lys Glu Leu 
1               5                   10                  15      


Ser Asp Ile Ala His Arg Ile Val Ala Pro Gly Lys Gly Ile Leu Ala 
            20                  25                  30          


Ala Asp Glu Ser Thr Gly Ser Ile Ala Lys Arg Leu Gln Ser Ile Gly 
        35                  40                  45              


Thr Glu Asn Thr Glu Glu Asn Arg Arg Phe Tyr Arg Gln Leu Leu Leu 
    50                  55                  60                  


Thr Ala Asp Asp Arg Val Asn Pro Cys Ile Gly Gly Val Ile Leu Phe 
65                  70                  75                  80  


His Glu Thr Leu Tyr Gln Lys Ala Asp Asp Gly Arg Pro Phe Pro Gln 
                85                  90                  95      


Val Ile Lys Ser Lys Gly Gly Val Val Gly Ile Lys Val Asp Lys Gly 
            100                 105                 110         


Val Val Pro Leu Ala Gly Thr Asn Gly Glu Thr Thr Thr Gln Gly Leu 
        115                 120                 125             


Asp Gly Leu Ser Glu Arg Cys Ala Gln Tyr Lys Lys Asp Gly Ala Asp 
    130                 135                 140                 


Phe Ala Lys Trp Arg Cys Val Leu Lys Ile Gly Glu His Thr Pro Ser 
145                 150                 155                 160 


Ala Leu Ala Ile Met Glu Asn Ala Asn Val Leu Ala Arg Tyr Ala Ser 
                165                 170                 175     


Ile Cys Gln Gln Asn Gly Ile Val Pro Ile Val Glu Pro Glu Ile Leu 
            180                 185                 190         


Pro Asp Gly Asp His Asp Leu Lys Arg Cys Gln Tyr Val Thr Glu Lys 
        195                 200                 205             


Val Leu Ala Ala Val Tyr Lys Ala Leu Ser Asp His His Ile Tyr Leu 
    210                 215                 220                 


Glu Gly Thr Leu Leu Lys Pro Asn Met Val Thr Pro Gly His Ala Cys 
225                 230                 235                 240 


Thr Gln Lys Phe Ser His Glu Glu Ile Ala Met Ala Thr Val Thr Ala 
                245                 250                 255     


Leu Arg Arg Thr Val Pro Pro Ala Val Thr Gly Ile Thr Phe Leu Ser 
            260                 265                 270         


Gly Gly Gln Ser Glu Glu Glu Ala Ser Ile Asn Leu Asn Ala Ile Asn 
        275                 280                 285             


Lys Cys Pro Leu Leu Lys Pro Trp Ala Leu Thr Phe Ser Tyr Gly Arg 
    290                 295                 300                 


Ala Leu Gln Ala Ser Ala Leu Lys Ala Trp Gly Gly Lys Lys Glu Asn 
305                 310                 315                 320 


Leu Lys Ala Ala Gln Glu Glu Tyr Val Lys Arg Ala Leu Ala Asn Ser 
                325                 330                 335     


Leu Ala Cys Gln Gly Lys Tyr Thr Pro Ser Gly Gln Ala Gly Ala Ala 
            340                 345                 350         


Ala Ser Glu Ser Leu Phe Val Ser Asn His Ala Tyr 
        355                 360                 


<210>  708
<211>  364
<212>  PRT
<213>  Homo Sapiens

<400>  708

Met Pro Tyr Gln Tyr Pro Ala Leu Thr Pro Glu Gln Lys Lys Glu Leu 
1               5                   10                  15      


Ser Asp Ile Ala His Arg Ile Val Ala Pro Gly Lys Gly Ile Leu Ala 
            20                  25                  30          


Ala Asp Glu Ser Thr Gly Ser Ile Ala Lys Arg Leu Gln Ser Ile Gly 
        35                  40                  45              


Thr Glu Asn Thr Glu Glu Asn Arg Arg Phe Tyr Arg Gln Leu Leu Leu 
    50                  55                  60                  


Thr Ala Asp Asp Arg Val Asn Pro Cys Ile Gly Gly Val Ile Leu Phe 
65                  70                  75                  80  


His Glu Thr Leu Tyr Gln Lys Ala Asp Asp Gly Arg Pro Phe Pro Gln 
                85                  90                  95      


Val Ile Lys Ser Lys Gly Gly Val Val Gly Ile Lys Val Asp Lys Gly 
            100                 105                 110         


Val Val Pro Leu Ala Gly Thr Asn Gly Glu Thr Thr Thr Gln Gly Leu 
        115                 120                 125             


Asp Gly Leu Ser Glu Arg Cys Ala Gln Tyr Lys Lys Asp Gly Ala Asp 
    130                 135                 140                 


Phe Ala Lys Trp Arg Cys Val Leu Lys Ile Gly Glu His Thr Pro Ser 
145                 150                 155                 160 


Ala Leu Ala Ile Met Glu Asn Ala Asn Val Leu Ala Arg Tyr Ala Ser 
                165                 170                 175     


Ile Cys Gln Gln Asn Gly Ile Val Pro Ile Val Glu Pro Glu Ile Leu 
            180                 185                 190         


Pro Asp Gly Asp His Asp Leu Lys Arg Cys Gln Tyr Val Thr Glu Lys 
        195                 200                 205             


Val Leu Ala Ala Val Tyr Lys Ala Leu Ser Asp His His Ile Tyr Leu 
    210                 215                 220                 


Glu Gly Thr Leu Leu Lys Pro Asn Met Val Thr Pro Gly His Ala Cys 
225                 230                 235                 240 


Thr Gln Lys Phe Ser His Glu Glu Ile Ala Met Ala Thr Val Thr Ala 
                245                 250                 255     


Leu Arg Arg Thr Val Pro Pro Ala Val Thr Gly Ile Thr Phe Leu Ser 
            260                 265                 270         


Gly Gly Gln Ser Glu Glu Glu Ala Ser Ile Asn Leu Asn Ala Ile Asn 
        275                 280                 285             


Lys Cys Pro Leu Leu Lys Pro Trp Ala Leu Thr Phe Ser Tyr Gly Arg 
    290                 295                 300                 


Ala Leu Gln Ala Ser Ala Leu Lys Ala Trp Gly Gly Lys Lys Glu Asn 
305                 310                 315                 320 


Leu Lys Ala Ala Gln Glu Glu Tyr Val Lys Arg Ala Leu Ala Asn Ser 
                325                 330                 335     


Leu Ala Cys Gln Gly Lys Tyr Thr Pro Ser Gly Gln Ala Gly Ala Ala 
            340                 345                 350         


Ala Ser Glu Ser Leu Phe Val Ser Asn His Ala Tyr 
        355                 360                 


<210>  709
<211>  364
<212>  PRT
<213>  Homo Sapiens

<400>  709

Met Pro Tyr Gln Tyr Pro Ala Leu Thr Pro Glu Gln Lys Lys Glu Leu 
1               5                   10                  15      


Ser Asp Ile Ala His Arg Ile Val Ala Pro Gly Lys Gly Ile Leu Ala 
            20                  25                  30          


Ala Asp Glu Ser Thr Gly Ser Ile Ala Lys Arg Leu Gln Ser Ile Gly 
        35                  40                  45              


Thr Glu Asn Thr Glu Glu Asn Arg Arg Phe Tyr Arg Gln Leu Leu Leu 
    50                  55                  60                  


Thr Ala Asp Asp Arg Val Asn Pro Cys Ile Gly Gly Val Ile Leu Phe 
65                  70                  75                  80  


His Glu Thr Leu Tyr Gln Lys Ala Asp Asp Gly Arg Pro Phe Pro Gln 
                85                  90                  95      


Val Ile Lys Ser Lys Gly Gly Val Val Gly Ile Lys Val Asp Lys Gly 
            100                 105                 110         


Val Val Pro Leu Ala Gly Thr Asn Gly Glu Thr Thr Thr Gln Gly Leu 
        115                 120                 125             


Asp Gly Leu Ser Glu Arg Cys Ala Gln Tyr Lys Lys Asp Gly Ala Asp 
    130                 135                 140                 


Phe Ala Lys Trp Arg Cys Val Leu Lys Ile Gly Glu His Thr Pro Ser 
145                 150                 155                 160 


Ala Leu Ala Ile Met Glu Asn Ala Asn Val Leu Ala Arg Tyr Ala Ser 
                165                 170                 175     


Ile Cys Gln Gln Asn Gly Ile Val Pro Ile Val Glu Pro Glu Ile Leu 
            180                 185                 190         


Pro Asp Gly Asp His Asp Leu Lys Arg Cys Gln Tyr Val Thr Glu Lys 
        195                 200                 205             


Val Leu Ala Ala Val Tyr Lys Ala Leu Ser Asp His His Ile Tyr Leu 
    210                 215                 220                 


Glu Gly Thr Leu Leu Lys Pro Asn Met Val Thr Pro Gly His Ala Cys 
225                 230                 235                 240 


Thr Gln Lys Phe Ser His Glu Glu Ile Ala Met Ala Thr Val Thr Ala 
                245                 250                 255     


Leu Arg Arg Thr Val Pro Pro Ala Val Thr Gly Ile Thr Phe Leu Ser 
            260                 265                 270         


Gly Gly Gln Ser Glu Glu Glu Ala Ser Ile Asn Leu Asn Ala Ile Asn 
        275                 280                 285             


Lys Cys Pro Leu Leu Lys Pro Trp Ala Leu Thr Phe Ser Tyr Gly Arg 
    290                 295                 300                 


Ala Leu Gln Ala Ser Ala Leu Lys Ala Trp Gly Gly Lys Lys Glu Asn 
305                 310                 315                 320 


Leu Lys Ala Ala Gln Glu Glu Tyr Val Lys Arg Ala Leu Ala Asn Ser 
                325                 330                 335     


Leu Ala Cys Gln Gly Lys Tyr Thr Pro Ser Gly Gln Ala Gly Ala Ala 
            340                 345                 350         


Ala Ser Glu Ser Leu Phe Val Ser Asn His Ala Tyr 
        355                 360                 


<210>  710
<211>  364
<212>  PRT
<213>  Homo Sapiens

<400>  710

Met Pro Tyr Gln Tyr Pro Ala Leu Thr Pro Glu Gln Lys Lys Glu Leu 
1               5                   10                  15      


Ser Asp Ile Ala His Arg Ile Val Ala Pro Gly Lys Gly Ile Leu Ala 
            20                  25                  30          


Ala Asp Glu Ser Thr Gly Ser Ile Ala Lys Arg Leu Gln Ser Ile Gly 
        35                  40                  45              


Thr Glu Asn Thr Glu Glu Asn Arg Arg Phe Tyr Arg Gln Leu Leu Leu 
    50                  55                  60                  


Thr Ala Asp Asp Arg Val Asn Pro Cys Ile Gly Gly Val Ile Leu Phe 
65                  70                  75                  80  


His Glu Thr Leu Tyr Gln Lys Ala Asp Asp Gly Arg Pro Phe Pro Gln 
                85                  90                  95      


Val Ile Lys Ser Lys Gly Gly Val Val Gly Ile Lys Val Asp Lys Gly 
            100                 105                 110         


Val Val Pro Leu Ala Gly Thr Asn Gly Glu Thr Thr Thr Gln Gly Leu 
        115                 120                 125             


Asp Gly Leu Ser Glu Arg Cys Ala Gln Tyr Lys Lys Asp Gly Ala Asp 
    130                 135                 140                 


Phe Ala Lys Trp Arg Cys Val Leu Lys Ile Gly Glu His Thr Pro Ser 
145                 150                 155                 160 


Ala Leu Ala Ile Met Glu Asn Ala Asn Val Leu Ala Arg Tyr Ala Ser 
                165                 170                 175     


Ile Cys Gln Gln Asn Gly Ile Val Pro Ile Val Glu Pro Glu Ile Leu 
            180                 185                 190         


Pro Asp Gly Asp His Asp Leu Lys Arg Cys Gln Tyr Val Thr Glu Lys 
        195                 200                 205             


Val Leu Ala Ala Val Tyr Lys Ala Leu Ser Asp His His Ile Tyr Leu 
    210                 215                 220                 


Glu Gly Thr Leu Leu Lys Pro Asn Met Val Thr Pro Gly His Ala Cys 
225                 230                 235                 240 


Thr Gln Lys Phe Ser His Glu Glu Ile Ala Met Ala Thr Val Thr Ala 
                245                 250                 255     


Leu Arg Arg Thr Val Pro Pro Ala Val Thr Gly Ile Thr Phe Leu Ser 
            260                 265                 270         


Gly Gly Gln Ser Glu Glu Glu Ala Ser Ile Asn Leu Asn Ala Ile Asn 
        275                 280                 285             


Lys Cys Pro Leu Leu Lys Pro Trp Ala Leu Thr Phe Ser Tyr Gly Arg 
    290                 295                 300                 


Ala Leu Gln Ala Ser Ala Leu Lys Ala Trp Gly Gly Lys Lys Glu Asn 
305                 310                 315                 320 


Leu Lys Ala Ala Gln Glu Glu Tyr Val Lys Arg Ala Leu Ala Asn Ser 
                325                 330                 335     


Leu Ala Cys Gln Gly Lys Tyr Thr Pro Ser Gly Gln Ala Gly Ala Ala 
            340                 345                 350         


Ala Ser Glu Ser Leu Phe Val Ser Asn His Ala Tyr 
        355                 360                 


<210>  711
<211>  361
<212>  PRT
<213>  Homo Sapiens

<400>  711

Met Pro Tyr Gln Tyr Pro Ala Leu Thr Pro Glu Gln Lys Lys Glu Leu 
1               5                   10                  15      


Ser Asp Ile Ala His Arg Ile Val Ala Pro Gly Lys Gly Ile Leu Ala 
            20                  25                  30          


Ala Asp Glu Ser Thr Gly Ser Ile Ala Lys Arg Leu Gln Ser Ile Gly 
        35                  40                  45              


Thr Glu Asn Thr Glu Glu Asn Arg Arg Phe Tyr Arg Gln Leu Leu Leu 
    50                  55                  60                  


Thr Ala Asp Asp Arg Val Asn Pro Cys Ile Gly Gly Val Ile Leu Phe 
65                  70                  75                  80  


His Glu Thr Leu Tyr Gln Lys Ala Asp Asp Gly Arg Pro Phe Pro Gln 
                85                  90                  95      


Val Ile Lys Ser Lys Gly Gly Val Val Gly Ile Lys Val Asp Lys Gly 
            100                 105                 110         


Val Val Pro Leu Ala Gly Thr Asn Gly Glu Thr Thr Thr Gln Gly Leu 
        115                 120                 125             


Asp Gly Leu Ser Glu Arg Cys Ala Gln Tyr Lys Lys Asp Gly Ala Asp 
    130                 135                 140                 


Phe Ala Lys Trp Arg Cys Val Leu Lys Ile Gly Glu His Thr Pro Ser 
145                 150                 155                 160 


Ala Leu Ala Ile Met Glu Asn Ala Asn Val Leu Ala Arg Tyr Ala Ser 
                165                 170                 175     


Ile Cys Gln Gln Asn Gly Ile Val Pro Ile Val Glu Pro Glu Ile Leu 
            180                 185                 190         


Pro Asp Gly Asp His Asp Leu Lys Arg Cys Gln Tyr Val Thr Glu Lys 
        195                 200                 205             


Val Leu Ala Ala Val Tyr Lys Ala Leu Ser Asp His His Ile Tyr Leu 
    210                 215                 220                 


Glu Gly Thr Leu Leu Lys Pro Asn Met Val Thr Pro Gly His Ala Cys 
225                 230                 235                 240 


Thr Gln Lys Phe Ser His Glu Glu Ile Ala Met Ala Thr Val Thr Ala 
                245                 250                 255     


Leu Arg Arg Thr Val Pro Pro Ala Val Thr Gly Ile Thr Phe Leu Ser 
            260                 265                 270         


Gly Gly Gln Ser Glu Glu Glu Ala Ser Ile Asn Leu Asn Ala Ile Asn 
        275                 280                 285             


Lys Cys Pro Leu Leu Lys Pro Trp Ala Leu Thr Phe Ser Tyr Gly Arg 
    290                 295                 300                 


Ala Leu Gln Ala Ser Ala Leu Lys Ala Trp Gly Gly Lys Lys Glu Asn 
305                 310                 315                 320 


Leu Lys Ala Ala Gln Glu Glu Tyr Val Lys Arg Ala Leu Val Arg Ile 
                325                 330                 335     


Gly Arg Arg Trp Ala Gly Cys Leu Gly Gly Trp Asp Ser Glu Lys Ser 
            340                 345                 350         


Pro Ser His Ser Thr Pro Leu Pro Ala 
        355                 360     


<210>  712
<211>  364
<212>  PRT
<213>  Homo Sapiens

<400>  712

Met Pro Tyr Gln Tyr Pro Ala Leu Thr Pro Glu Gln Lys Lys Glu Leu 
1               5                   10                  15      


Ser Asp Ile Ala His Arg Ile Val Ala Pro Gly Lys Gly Ile Leu Ala 
            20                  25                  30          


Ala Asp Glu Ser Thr Gly Ser Ile Ala Lys Arg Leu Gln Ser Ile Gly 
        35                  40                  45              


Thr Glu Asn Thr Glu Glu Asn Arg Arg Phe Tyr Arg Gln Leu Leu Leu 
    50                  55                  60                  


Thr Ala Asp Asp Arg Val Asn Pro Cys Ile Gly Gly Val Ile Leu Phe 
65                  70                  75                  80  


His Glu Thr Leu Tyr Gln Lys Ala Asp Asp Gly Arg Pro Phe Pro Gln 
                85                  90                  95      


Val Ile Lys Ser Lys Gly Gly Val Val Gly Ile Lys Val Asp Lys Gly 
            100                 105                 110         


Val Val Pro Leu Ala Gly Thr Asn Gly Glu Thr Thr Thr Gln Gly Leu 
        115                 120                 125             


Asp Gly Leu Ser Glu Arg Cys Ala Gln Tyr Lys Lys Asp Gly Ala Asp 
    130                 135                 140                 


Phe Ala Lys Trp Arg Cys Val Leu Lys Ile Gly Glu His Thr Pro Ser 
145                 150                 155                 160 


Ala Leu Ala Ile Met Glu Asn Ala Asn Val Leu Ala Arg Tyr Ala Ser 
                165                 170                 175     


Ile Cys Gln Gln Asn Gly Ile Val Pro Ile Val Glu Pro Glu Ile Leu 
            180                 185                 190         


Pro Asp Gly Asp His Asp Leu Lys Arg Cys Gln Tyr Val Thr Glu Lys 
        195                 200                 205             


Val Leu Ala Ala Val Tyr Lys Ala Leu Ser Asp His His Ile Tyr Leu 
    210                 215                 220                 


Glu Gly Thr Leu Leu Lys Pro Asn Met Val Thr Pro Gly His Ala Cys 
225                 230                 235                 240 


Thr Gln Lys Phe Ser His Glu Glu Ile Ala Met Ala Thr Val Thr Ala 
                245                 250                 255     


Leu Arg Arg Thr Val Pro Pro Ala Val Thr Gly Ile Thr Phe Leu Ser 
            260                 265                 270         


Gly Gly Gln Ser Glu Glu Glu Ala Ser Ile Asn Leu Asn Ala Ile Asn 
        275                 280                 285             


Lys Cys Pro Leu Leu Lys Pro Trp Ala Leu Thr Phe Ser Tyr Gly Arg 
    290                 295                 300                 


Ala Leu Gln Ala Ser Ala Leu Lys Ala Trp Gly Gly Lys Lys Glu Asn 
305                 310                 315                 320 


Leu Lys Ala Ala Gln Glu Glu Tyr Val Lys Arg Ala Leu Ala Asn Ser 
                325                 330                 335     


Leu Ala Cys Gln Gly Lys Tyr Thr Pro Ser Gly Gln Ala Gly Ala Ala 
            340                 345                 350         


Ala Ser Glu Ser Leu Phe Val Ser Asn His Ala Tyr 
        355                 360                 


<210>  713
<211>  368
<212>  PRT
<213>  Homo Sapiens

<400>  713

Met Pro Tyr Gln Tyr Pro Ala Leu Thr Pro Glu Gln Lys Lys Glu Leu 
1               5                   10                  15      


Ser Asp Ile Ala His Arg Ile Val Ala Pro Gly Lys Gly Ile Leu Ala 
            20                  25                  30          


Ala Asp Glu Ser Thr Gly Ser Ile Ala Lys Arg Leu Gln Ser Ile Gly 
        35                  40                  45              


Thr Glu Asn Thr Glu Glu Asn Arg Arg Phe Tyr Arg Gln Leu Leu Leu 
    50                  55                  60                  


Thr Ala Asp Asp Arg Val Asn Pro Cys Ile Gly Gly Val Ile Leu Phe 
65                  70                  75                  80  


His Glu Thr Leu Tyr Gln Lys Ala Asp Asp Gly Arg Pro Phe Pro Gln 
                85                  90                  95      


Val Ile Lys Ser Lys Gly Gly Val Val Gly Ile Lys Val Asp Lys Gly 
            100                 105                 110         


Val Val Pro Leu Ala Gly Thr Asn Gly Glu Thr Thr Thr Gln Gly Leu 
        115                 120                 125             


Asp Gly Leu Ser Glu Arg Cys Ala Gln Tyr Lys Lys Asp Gly Ala Asp 
    130                 135                 140                 


Phe Ala Lys Trp Arg Cys Val Leu Lys Ile Gly Glu His Thr Pro Ser 
145                 150                 155                 160 


Ala Leu Ala Ile Met Glu Asn Ala Asn Val Leu Ala Arg Tyr Ala Ser 
                165                 170                 175     


Ile Cys Gln Gln Val Gly Leu Gln Asn Gly Ile Val Pro Ile Val Glu 
            180                 185                 190         


Pro Glu Ile Leu Pro Asp Gly Asp His Asp Leu Lys Arg Cys Gln Tyr 
        195                 200                 205             


Val Thr Glu Lys Val Leu Ala Ala Val Tyr Lys Ala Leu Ser Asp His 
    210                 215                 220                 


His Ile Tyr Leu Glu Gly Thr Leu Leu Lys Pro Asn Met Val Thr Pro 
225                 230                 235                 240 


Gly His Ala Cys Thr Gln Lys Phe Ser His Glu Glu Ile Ala Met Ala 
                245                 250                 255     


Thr Val Thr Ala Leu Arg Arg Thr Val Pro Pro Ala Val Thr Gly Ile 
            260                 265                 270         


Thr Phe Leu Ser Gly Gly Gln Ser Glu Glu Glu Ala Ser Ile Asn Leu 
        275                 280                 285             


Asn Ala Ile Asn Lys Cys Pro Leu Leu Lys Pro Trp Ala Leu Thr Phe 
    290                 295                 300                 


Ser Tyr Gly Arg Ala Leu Gln Ala Ser Ala Leu Lys Ala Trp Gly Gly 
305                 310                 315                 320 


Lys Lys Glu Asn Leu Lys Ala Ala Gln Glu Glu Tyr Val Lys Arg Ala 
                325                 330                 335     


Leu Ala Asn Ser Leu Ala Cys Gln Gly Lys Tyr Thr Pro Ser Gly Gln 
            340                 345                 350         


Ala Gly Ala Ala Ala Ser Glu Ser Leu Phe Val Ser Asn His Ala Tyr 
        355                 360                 365             


<210>  714
<211>  140
<212>  PRT
<213>  Homo Sapiens

<400>  714

Met Pro Tyr Gln Tyr Pro Ala Leu Thr Pro Glu Gln Lys Lys Glu Leu 
1               5                   10                  15      


Ser Asp Ile Ala His Arg Ile Val Ala Pro Gly Ser Ile Ala Lys Arg 
            20                  25                  30          


Leu Gln Ser Ile Gly Thr Glu Asn Thr Glu Glu Asn Arg Arg Phe Tyr 
        35                  40                  45              


Arg Gln Leu Leu Leu Thr Ala Asp Asp Arg Val Asn Pro Cys Ile Gly 
    50                  55                  60                  


Gly Val Ile Leu Phe His Glu Thr Leu Tyr Gln Lys Ala Asp Asp Gly 
65                  70                  75                  80  


Arg Pro Phe Pro Gln Val Ile Lys Ser Lys Gly Gly Val Val Gly Ile 
                85                  90                  95      


Lys Val Asp Lys Gly Val Val Pro Leu Ala Gly Thr Asn Gly Glu Thr 
            100                 105                 110         


Thr Thr Gln Gly Leu Asp Gly Leu Ser Glu Arg Cys Ala Gln Tyr Lys 
        115                 120                 125             


Lys Asp Gly Ala Asp Phe Ala Lys Trp Arg Cys Val 
    130                 135                 140 


<210>  715
<211>  162
<212>  PRT
<213>  Homo Sapiens

<400>  715

Met Pro Tyr Gln Tyr Pro Ala Leu Thr Pro Glu Gln Lys Lys Glu Leu 
1               5                   10                  15      


Ser Asp Ile Ala His Arg Ile Val Ala Pro Gly Ser Ile Ala Lys Arg 
            20                  25                  30          


Leu Gln Ser Ile Gly Thr Glu Asn Thr Glu Glu Asn Arg Arg Phe Tyr 
        35                  40                  45              


Arg Gln Leu Leu Leu Thr Ala Asp Asp Arg Val Asn Pro Cys Ile Gly 
    50                  55                  60                  


Gly Val Ile Leu Phe His Glu Thr Leu Tyr Gln Lys Ala Asp Asp Gly 
65                  70                  75                  80  


Arg Pro Phe Pro Gln Val Ile Lys Ser Lys Gly Gly Val Val Gly Ile 
                85                  90                  95      


Lys Val Asp Lys Gly Val Val Pro Leu Ala Gly Thr Asn Gly Glu Thr 
            100                 105                 110         


Thr Thr Gln Gly Leu Asp Gly Leu Ser Glu Arg Cys Ala Gln Tyr Lys 
        115                 120                 125             


Lys Asp Gly Ala Asp Phe Ala Lys Trp Arg Cys Val Leu Lys Ile Gly 
    130                 135                 140                 


Glu His Thr Pro Ser Ala Leu Ala Ile Met Glu Asn Ala Asn Val Leu 
145                 150                 155                 160 


Ala Arg 
        


<210>  716
<211>  204
<212>  PRT
<213>  Homo Sapiens

<400>  716

Arg Arg Phe Tyr Arg Gln Leu Leu Leu Thr Ala Asp Asp Arg Val Asn 
1               5                   10                  15      


Pro Cys Ile Gly Gly Val Ile Leu Phe His Glu Thr Leu Tyr Gln Lys 
            20                  25                  30          


Ala Asp Asp Gly Arg Pro Phe Pro Gln Val Ile Lys Ser Lys Gly Gly 
        35                  40                  45              


Val Val Gly Ile Lys Val Asp Lys Gly Val Val Pro Leu Ala Gly Thr 
    50                  55                  60                  


Asn Gly Glu Thr Thr Thr Gln Gly Leu Asp Gly Leu Ser Glu Arg Cys 
65                  70                  75                  80  


Ala Gln Tyr Lys Lys Asp Gly Ala Asp Phe Ala Lys Trp Arg Cys Val 
                85                  90                  95      


Leu Lys Ile Gly Glu His Thr Pro Ser Ala Leu Ala Ile Met Glu Asn 
            100                 105                 110         


Ala Asn Val Leu Ala Arg Tyr Ala Ser Ile Cys Gln Gln Val Leu Ala 
        115                 120                 125             


Ala Val Tyr Lys Ala Leu Ser Asp His His Ile Tyr Leu Glu Gly Thr 
    130                 135                 140                 


Leu Leu Lys Pro Asn Met Val Thr Pro Gly His Ala Cys Thr Gln Lys 
145                 150                 155                 160 


Phe Ser His Glu Glu Ile Ala Met Ala Thr Val Thr Ala Leu Arg Arg 
                165                 170                 175     


Thr Val Pro Pro Ala Val Thr Gly Ile Thr Phe Leu Ser Gly Gly Gln 
            180                 185                 190         


Ser Glu Glu Glu Ala Ser Ile Asn Leu Asn Ala Ile 
        195                 200                 


<210>  717
<211>  130
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  717

Xaa Pro Gly His Ala Cys Thr Gln Lys Phe Ser His Glu Glu Ile Ala 
1               5                   10                  15      


Met Ala Thr Val Thr Ala Leu Arg Arg Thr Val Pro Pro Ala Val Thr 
            20                  25                  30          


Gly Ile Thr Phe Leu Ser Gly Gly Gln Ser Glu Glu Glu Ala Ser Ile 
        35                  40                  45              


Asn Leu Asn Ala Ile Asn Lys Cys Pro Leu Leu Lys Pro Trp Ala Leu 
    50                  55                  60                  


Thr Phe Ser Tyr Gly Arg Ala Leu Gln Ala Ser Ala Leu Lys Ala Trp 
65                  70                  75                  80  


Gly Gly Lys Lys Glu Asn Leu Lys Ala Ala Gln Glu Glu Tyr Val Lys 
                85                  90                  95      


Arg Ala Leu Ala Asn Ser Leu Ala Cys Gln Gly Lys Tyr Thr Pro Ser 
            100                 105                 110         


Gly Gln Ala Gly Ala Ala Ala Ser Glu Ser Leu Phe Val Ser Asn His 
        115                 120                 125             


Ala Tyr 
    130 


<210>  718
<211>  464
<212>  PRT
<213>  Homo Sapiens

<400>  718

Met Ala Ala Ser Cys Leu Val Leu Leu Ala Leu Cys Leu Leu Leu Pro 
1               5                   10                  15      


Leu Leu Leu Leu Gly Gly Trp Lys Arg Trp Arg Arg Gly Arg Ala Ala 
            20                  25                  30          


Arg His Val Val Ala Val Val Leu Gly Asp Val Gly Arg Ser Pro Arg 
        35                  40                  45              


Met Gln Tyr His Ala Leu Ser Leu Ala Met His Gly Phe Ser Val Thr 
    50                  55                  60                  


Leu Leu Gly Phe Cys Asn Ser Lys Pro His Asp Glu Leu Leu Gln Asn 
65                  70                  75                  80  


Asn Arg Ile Gln Ile Val Gly Leu Thr Glu Leu Gln Ser Leu Ala Val 
                85                  90                  95      


Gly Pro Arg Val Phe Gln Tyr Gly Val Lys Val Val Leu Gln Ala Met 
            100                 105                 110         


Tyr Leu Leu Trp Lys Leu Met Trp Arg Glu Pro Gly Ala Tyr Ile Phe 
        115                 120                 125             


Leu Gln Asn Pro Pro Gly Leu Pro Ser Ile Ala Val Cys Trp Phe Val 
    130                 135                 140                 


Gly Cys Leu Cys Gly Ser Lys Leu Val Ile Asp Trp His Asn Tyr Gly 
145                 150                 155                 160 


Tyr Ser Ile Met Gly Leu Val His Gly Pro Asn His Pro Leu Val Leu 
                165                 170                 175     


Leu Ala Lys Trp Tyr Glu Lys Phe Phe Gly Arg Leu Ser His Leu Asn 
            180                 185                 190         


Leu Cys Val Thr Asn Ala Met Arg Glu Asp Leu Ala Asp Asn Trp His 
        195                 200                 205             


Ile Arg Ala Val Thr Val Tyr Asp Lys Pro Ala Ser Phe Phe Lys Glu 
    210                 215                 220                 


Thr Pro Leu Asp Leu Gln His Arg Leu Phe Met Lys Leu Gly Ser Met 
225                 230                 235                 240 


His Ser Pro Phe Arg Ala Arg Ser Glu Pro Glu Asp Pro Val Thr Glu 
                245                 250                 255     


Arg Ser Ala Phe Thr Glu Arg Asp Ala Gly Ser Gly Leu Val Thr Arg 
            260                 265                 270         


Leu Arg Glu Arg Pro Ala Leu Leu Val Ser Ser Thr Ser Trp Thr Glu 
        275                 280                 285             


Asp Glu Asp Phe Ser Ile Leu Leu Ala Ala Leu Glu Lys Phe Glu Gln 
    290                 295                 300                 


Leu Thr Leu Asp Gly His Asn Leu Pro Ser Leu Val Cys Val Ile Thr 
305                 310                 315                 320 


Gly Lys Gly Pro Leu Arg Glu Tyr Tyr Ser Arg Leu Ile His Gln Lys 
                325                 330                 335     


His Phe Gln His Ile Gln Val Cys Thr Pro Trp Leu Glu Ala Glu Asp 
            340                 345                 350         


Tyr Pro Leu Leu Leu Gly Ser Ala Asp Leu Gly Val Cys Leu His Thr 
        355                 360                 365             


Ser Ser Ser Gly Leu Asp Leu Pro Met Lys Val Val Asp Met Phe Gly 
    370                 375                 380                 


Cys Cys Leu Pro Val Cys Ala Val Asn Phe Lys Cys Leu His Glu Leu 
385                 390                 395                 400 


Val Lys His Glu Glu Asn Gly Leu Val Phe Glu Asp Ser Glu Glu Leu 
                405                 410                 415     


Ala Ala Gln Leu Gln Met Leu Phe Ser Asn Phe Pro Asp Pro Ala Gly 
            420                 425                 430         


Lys Leu Asn Gln Phe Arg Lys Asn Leu Arg Glu Ser Gln Gln Leu Arg 
        435                 440                 445             


Trp Asp Glu Ser Trp Val Gln Thr Val Leu Pro Leu Val Met Asp Thr 
    450                 455                 460                 


<210>  719
<211>  184
<212>  PRT
<213>  Homo Sapiens

<400>  719

Met Ala Ala Ser Cys Leu Val Leu Leu Ala Leu Cys Leu Leu Leu Pro 
1               5                   10                  15      


Leu Leu Leu Leu Gly Gly Trp Lys Arg Trp Arg Arg Gly Arg Ala Ala 
            20                  25                  30          


Arg His Val Val Ala Val Val Leu Gly Asp Val Gly Arg Ser Pro Arg 
        35                  40                  45              


Met Gln Tyr His Ala Leu Ser Leu Ala Met His Gly Phe Ser Val Thr 
    50                  55                  60                  


Leu Leu Gly Phe Cys Asn Ser Lys Pro His Asp Glu Leu Leu Gln Asn 
65                  70                  75                  80  


Asn Arg Ile Gln Ile Val Gly Leu Thr Glu Leu Gln Ser Leu Ala Val 
                85                  90                  95      


Gly Pro Arg Val Phe Gln Tyr Gly Val Lys Val Val Leu Gln Ala Met 
            100                 105                 110         


Tyr Leu Leu Trp Lys Leu Met Trp Arg Glu Pro Gly Ala Tyr Ile Phe 
        115                 120                 125             


Leu Gln Val Cys Leu Ala Leu Leu Ser Ala Gly Ser Trp Ala Ala Phe 
    130                 135                 140                 


Val Glu Ala Ser Ser Ser Leu Thr Gly Thr Thr Met Ala Thr Pro Ser 
145                 150                 155                 160 


Trp Val Trp Cys Met Ala Pro Thr Ile Pro Ser Phe Cys Trp Pro Ser 
                165                 170                 175     


Gly Thr Arg Ser Ser Leu Gly Ala 
            180                 


<210>  720
<211>  84
<212>  PRT
<213>  Homo Sapiens

<400>  720

Met Ala Ala Ser Cys Leu Val Leu Leu Ala Leu Cys Leu Leu Leu Pro 
1               5                   10                  15      


Leu Leu Leu Leu Gly Gly Trp Lys Arg Trp Arg Arg Gly Arg Ala Ala 
            20                  25                  30          


Arg His Val Val Ala Val Val Leu Gly Asp Val Gly Arg Ser Pro Arg 
        35                  40                  45              


Met Gln Tyr His Ala Leu Ser Leu Ala Met His Gly Phe Ser Val Thr 
    50                  55                  60                  


Leu Leu Gly Phe Cys Ser Glu Trp Pro Arg Val Trp Glu Gly Arg Cys 
65                  70                  75                  80  


Ser Leu Ser Arg 
                


<210>  721
<211>  168
<212>  PRT
<213>  Homo Sapiens

<400>  721

Met Tyr Leu Leu Trp Lys Leu Met Trp Arg Glu Pro Gly Ala Tyr Ile 
1               5                   10                  15      


Phe Leu Gln Asn Pro Pro Gly Leu Pro Ser Ile Ala Val Cys Trp Phe 
            20                  25                  30          


Val Gly Cys Leu Cys Gly Ser Lys Leu Val Ile Asp Trp His Asn Tyr 
        35                  40                  45              


Gly Tyr Ser Ile Met Gly Leu Val His Gly Pro Asn His Pro Leu Val 
    50                  55                  60                  


Leu Leu Ala Lys Trp Tyr Glu Lys Phe Phe Gly Arg Leu Ser His Leu 
65                  70                  75                  80  


Asn Leu Cys Val Thr Asn Ala Met Arg Glu Asp Leu Ala Asp Asn Trp 
                85                  90                  95      


His Ile Arg Ala Val Thr Val Tyr Asp Lys Pro Ala Ser Phe Phe Lys 
            100                 105                 110         


Glu Thr Pro Leu Asp Leu Gln His Arg Leu Phe Met Lys Leu Gly Ser 
        115                 120                 125             


Met His Ser Pro Phe Arg Ala Arg Ser Glu Pro Glu Asp Pro Val Thr 
    130                 135                 140                 


Glu Arg Ser Ala Phe Thr Glu Arg Asp Ala Gly Ser Gly Leu Val Thr 
145                 150                 155                 160 


Arg Leu Arg Glu Arg Pro Ala Leu 
                165             


<210>  722
<211>  353
<212>  PRT
<213>  Homo Sapiens

<400>  722

Met Tyr Leu Leu Trp Lys Leu Met Trp Arg Glu Pro Gly Ala Tyr Ile 
1               5                   10                  15      


Phe Leu Gln Asn Pro Pro Gly Leu Pro Ser Ile Ala Val Cys Trp Phe 
            20                  25                  30          


Val Gly Cys Leu Cys Gly Ser Lys Leu Val Ile Asp Trp His Asn Tyr 
        35                  40                  45              


Gly Tyr Ser Ile Met Gly Leu Val His Gly Pro Asn His Pro Leu Val 
    50                  55                  60                  


Leu Leu Ala Lys Trp Tyr Glu Lys Phe Phe Gly Arg Leu Ser His Leu 
65                  70                  75                  80  


Asn Leu Cys Val Thr Asn Ala Met Arg Glu Asp Leu Ala Asp Asn Trp 
                85                  90                  95      


His Ile Arg Ala Val Thr Val Tyr Asp Lys Pro Ala Ser Phe Phe Lys 
            100                 105                 110         


Glu Thr Pro Leu Asp Leu Gln His Arg Leu Phe Met Lys Leu Gly Ser 
        115                 120                 125             


Met His Ser Pro Phe Arg Ala Arg Ser Glu Pro Glu Asp Pro Val Thr 
    130                 135                 140                 


Glu Arg Ser Ala Phe Thr Glu Arg Asp Ala Gly Ser Gly Leu Val Thr 
145                 150                 155                 160 


Arg Leu Arg Glu Arg Pro Ala Leu Leu Val Ser Ser Thr Ser Trp Thr 
                165                 170                 175     


Glu Asp Glu Asp Phe Ser Ile Leu Leu Ala Ala Leu Glu Lys Phe Glu 
            180                 185                 190         


Gln Leu Thr Leu Asp Gly His Asn Leu Pro Ser Leu Val Cys Val Ile 
        195                 200                 205             


Thr Gly Lys Gly Pro Leu Arg Glu Tyr Tyr Ser Arg Leu Ile His Gln 
    210                 215                 220                 


Lys His Phe Gln His Ile Gln Val Cys Thr Pro Trp Leu Glu Ala Glu 
225                 230                 235                 240 


Asp Tyr Pro Leu Leu Leu Gly Ser Ala Asp Leu Gly Val Cys Leu His 
                245                 250                 255     


Thr Ser Ser Ser Gly Leu Asp Leu Pro Met Lys Val Val Asp Met Phe 
            260                 265                 270         


Gly Cys Cys Leu Pro Val Cys Ala Val Asn Phe Lys Cys Leu His Glu 
        275                 280                 285             


Leu Val Lys His Glu Glu Asn Gly Leu Val Phe Glu Asp Ser Glu Glu 
    290                 295                 300                 


Leu Ala Ala Gln Leu Gln Met Leu Phe Ser Asn Phe Pro Asp Pro Ala 
305                 310                 315                 320 


Gly Lys Leu Asn Gln Phe Arg Lys Asn Leu Arg Glu Ser Gln Gln Leu 
                325                 330                 335     


Arg Trp Asp Glu Ser Trp Val Gln Thr Val Leu Pro Leu Val Met Asp 
            340                 345                 350         


Thr 
    


<210>  723
<211>  353
<212>  PRT
<213>  Homo Sapiens

<400>  723

Met Tyr Leu Leu Trp Lys Leu Met Trp Arg Glu Pro Gly Ala Tyr Ile 
1               5                   10                  15      


Phe Leu Gln Asn Pro Pro Gly Leu Pro Ser Ile Ala Val Cys Trp Phe 
            20                  25                  30          


Val Gly Cys Leu Cys Gly Ser Lys Leu Val Ile Asp Trp His Asn Tyr 
        35                  40                  45              


Gly Tyr Ser Ile Met Gly Leu Val His Gly Pro Asn His Pro Leu Val 
    50                  55                  60                  


Leu Leu Ala Lys Trp Tyr Glu Lys Phe Phe Gly Arg Leu Ser His Leu 
65                  70                  75                  80  


Asn Leu Cys Val Thr Asn Ala Met Arg Glu Asp Leu Ala Asp Asn Trp 
                85                  90                  95      


His Ile Arg Ala Val Thr Val Tyr Asp Lys Pro Ala Ser Phe Phe Lys 
            100                 105                 110         


Glu Thr Pro Leu Asp Leu Gln His Arg Leu Phe Met Lys Leu Gly Ser 
        115                 120                 125             


Met His Ser Pro Phe Arg Ala Arg Ser Glu Pro Glu Asp Pro Val Thr 
    130                 135                 140                 


Glu Arg Ser Ala Phe Thr Glu Arg Asp Ala Gly Ser Gly Leu Val Thr 
145                 150                 155                 160 


Arg Leu Arg Glu Arg Pro Ala Leu Leu Val Ser Ser Thr Ser Trp Thr 
                165                 170                 175     


Glu Asp Glu Asp Phe Ser Ile Leu Leu Ala Ala Leu Glu Lys Phe Glu 
            180                 185                 190         


Gln Leu Thr Leu Asp Gly His Asn Leu Pro Ser Leu Val Cys Val Ile 
        195                 200                 205             


Thr Gly Lys Gly Pro Leu Arg Glu Tyr Tyr Ser Arg Leu Ile His Gln 
    210                 215                 220                 


Lys His Phe Gln His Ile Gln Val Cys Thr Pro Trp Leu Glu Ala Glu 
225                 230                 235                 240 


Asp Tyr Pro Leu Leu Leu Gly Ser Ala Asp Leu Gly Val Cys Leu His 
                245                 250                 255     


Thr Ser Ser Ser Gly Leu Asp Leu Pro Met Lys Val Val Asp Met Phe 
            260                 265                 270         


Gly Cys Cys Leu Pro Val Cys Ala Val Asn Phe Lys Cys Leu His Glu 
        275                 280                 285             


Leu Val Lys His Glu Glu Asn Gly Leu Val Phe Glu Asp Ser Glu Glu 
    290                 295                 300                 


Leu Ala Ala Gln Leu Gln Met Leu Phe Ser Asn Phe Pro Asp Pro Ala 
305                 310                 315                 320 


Gly Lys Leu Asn Gln Phe Arg Lys Asn Leu Arg Glu Ser Gln Gln Leu 
                325                 330                 335     


Arg Trp Asp Glu Ser Trp Val Gln Thr Val Leu Pro Leu Val Met Asp 
            340                 345                 350         


Thr 
    


<210>  724
<211>  324
<212>  PRT
<213>  Homo Sapiens

<400>  724

Met Ala Pro Leu Leu Leu Gln Leu Ala Val Leu Gly Ala Ala Leu Ala 
1               5                   10                  15      


Ala Ala Ala Leu Val Leu Ile Ser Ile Val Ala Phe Thr Thr Ala Thr 
            20                  25                  30          


Lys Met Pro Ala Leu His Arg His Glu Glu Glu Lys Phe Phe Leu Asn 
        35                  40                  45              


Ala Lys Gly Gln Lys Glu Thr Leu Pro Ser Ile Trp Asp Ser Pro Thr 
    50                  55                  60                  


Lys Gln Leu Ser Val Val Val Pro Ser Tyr Asn Glu Glu Lys Arg Leu 
65                  70                  75                  80  


Pro Val Met Met Asp Glu Ala Leu Ser Tyr Leu Glu Lys Arg Gln Lys 
                85                  90                  95      


Arg Asp Pro Ala Phe Thr Tyr Glu Val Ile Val Val Asp Asp Gly Ser 
            100                 105                 110         


Lys Asp Gln Thr Ser Lys Val Ala Phe Lys Tyr Cys Gln Lys Tyr Gly 
        115                 120                 125             


Ser Asp Lys Val Arg Val Ile Thr Leu Val Lys Asn Arg Gly Lys Gly 
    130                 135                 140                 


Gly Ala Ile Arg Met Gly Ile Phe Ser Ser Arg Gly Glu Lys Ile Leu 
145                 150                 155                 160 


Met Ala Asp Ala Asp Gly Ala Thr Lys Phe Pro Asp Val Glu Lys Leu 
                165                 170                 175     


Glu Lys Gly Leu Asn Asp Leu Gln Pro Trp Pro Asn Gln Met Ala Ile 
            180                 185                 190         


Ala Cys Gly Ser Arg Ala His Leu Glu Lys Glu Ser Ile Ala Gln Arg 
        195                 200                 205             


Ser Tyr Phe Arg Thr Leu Leu Met Tyr Gly Phe His Phe Leu Val Trp 
    210                 215                 220                 


Phe Leu Cys Val Lys Gly Ile Arg Asp Thr Gln Cys Gly Phe Lys Leu 
225                 230                 235                 240 


Phe Thr Arg Glu Ala Ala Ser Arg Thr Phe Ser Ser Leu His Val Glu 
                245                 250                 255     


Arg Trp Ala Phe Asp Val Glu Leu Leu Tyr Ile Ala Gln Phe Phe Lys 
            260                 265                 270         


Ile Pro Ile Ala Glu Ile Ala Val Asn Trp Thr Glu Ile Glu Gly Ser 
        275                 280                 285             


Lys Leu Val Pro Phe Trp Ser Trp Leu Gln Met Gly Lys Asp Leu Leu 
    290                 295                 300                 


Phe Ile Arg Leu Arg Tyr Leu Thr Gly Ala Trp Arg Leu Glu Gln Thr 
305                 310                 315                 320 


Arg Lys Met Asn 
                


<210>  725
<211>  294
<212>  PRT
<213>  Homo Sapiens

<400>  725

Met Ala Pro Leu Leu Leu Gln Leu Ala Val Leu Gly Ala Ala Leu Ala 
1               5                   10                  15      


Ala Ala Ala Leu Val Leu Ile Ser Ile Val Ala Phe Thr Thr Ala Thr 
            20                  25                  30          


Lys Met Pro Ala Leu His Arg His Glu Glu Glu Lys Phe Phe Leu Asn 
        35                  40                  45              


Ala Lys Gly Gln Lys Glu Thr Leu Pro Ser Ile Trp Asp Ser Pro Thr 
    50                  55                  60                  


Lys Gln Leu Ser Val Val Val Pro Ser Tyr Asn Glu Glu Lys Arg Leu 
65                  70                  75                  80  


Pro Val Met Met Asp Glu Ala Leu Ser Tyr Leu Glu Lys Arg Gln Lys 
                85                  90                  95      


Tyr Gly Ser Asp Lys Val Arg Val Ile Thr Leu Val Lys Asn Arg Gly 
            100                 105                 110         


Lys Gly Gly Ala Ile Arg Met Gly Ile Phe Ser Ser Arg Gly Glu Lys 
        115                 120                 125             


Ile Leu Met Ala Asp Ala Asp Gly Ala Thr Lys Phe Pro Asp Val Glu 
    130                 135                 140                 


Lys Leu Glu Lys Gly Leu Asn Asp Leu Gln Pro Trp Pro Asn Gln Met 
145                 150                 155                 160 


Ala Ile Ala Cys Gly Ser Arg Ala His Leu Glu Lys Glu Ser Ile Ala 
                165                 170                 175     


Gln Arg Ser Tyr Phe Arg Thr Leu Leu Met Tyr Gly Phe His Phe Leu 
            180                 185                 190         


Val Trp Phe Leu Cys Val Lys Gly Ile Arg Asp Thr Gln Cys Gly Phe 
        195                 200                 205             


Lys Leu Phe Thr Arg Glu Ala Ala Ser Arg Thr Phe Ser Ser Leu His 
    210                 215                 220                 


Val Glu Arg Trp Ala Phe Asp Val Glu Leu Leu Tyr Ile Ala Gln Phe 
225                 230                 235                 240 


Phe Lys Ile Pro Ile Ala Glu Ile Ala Val Asn Trp Thr Glu Ile Glu 
                245                 250                 255     


Gly Ser Lys Leu Val Pro Phe Trp Ser Trp Leu Gln Met Gly Lys Asp 
            260                 265                 270         


Leu Leu Phe Ile Arg Leu Arg Tyr Leu Thr Gly Ala Trp Arg Leu Glu 
        275                 280                 285             


Gln Thr Arg Lys Met Asn 
    290                 


<210>  726
<211>  102
<212>  PRT
<213>  Homo Sapiens

<400>  726

Met Ala Ser Arg Gly Ala Arg Gln Arg Leu Lys Gly Ser Gly Ala Ser 
1               5                   10                  15      


Ser Gly Asp Thr Ala Pro Ala Ala Asp Lys Leu Arg Glu Leu Leu Gly 
            20                  25                  30          


Ser Arg Glu Ala Gly Gly Ala Glu His Arg Thr Glu His Thr Thr Ser 
        35                  40                  45              


Ser Met Gly Lys Gly Phe Arg Leu Gly Asn Ile Pro Gln His Met Pro 
    50                  55                  60                  


Phe Ala Pro Met Leu Thr Cys Cys Phe Met Pro Gly Gln Leu His Phe 
65                  70                  75                  80  


Met Gln Glu Phe Tyr Lys Leu Ile Arg Phe Leu Cys Phe Thr Phe Cys 
                85                  90                  95      


Asp Val Phe Trp Leu Leu 
            100         


<210>  727
<211>  168
<212>  PRT
<213>  Homo Sapiens

<400>  727

Met Ala Ser Arg Gly Ala Arg Gln Arg Leu Lys Gly Ser Gly Ala Ser 
1               5                   10                  15      


Ser Gly Asp Thr Ala Pro Ala Ala Asp Lys Leu Arg Glu Leu Leu Gly 
            20                  25                  30          


Ser Arg Glu Ala Gly Gly Ala Glu His Arg Thr Glu Leu Ser Gly Asn 
        35                  40                  45              


Lys Ala Gly Gln Val Trp Ala Pro Glu Gly Ser Thr Ala Phe Lys Cys 
    50                  55                  60                  


Leu Leu Ser Ala Arg Leu Cys Ala Ala Leu Leu Ser Asn Ile Ser Asp 
65                  70                  75                  80  


Cys Asp Glu Thr Phe Asn Tyr Trp Glu Pro Thr His Tyr Leu Ile Tyr 
                85                  90                  95      


Gly Glu Gly Phe Gln Thr Trp Glu Tyr Ser Pro Ala Tyr Ala Ile Arg 
            100                 105                 110         


Ser Tyr Ala Tyr Leu Leu Leu His Ala Trp Pro Ala Ala Phe His Ala 
        115                 120                 125             


Arg Ile Leu Gln Thr Asn Lys Gly Cys Val Gln Glu Val Trp Val Ala 
    130                 135                 140                 


Arg Glu Ser Asn Asp Ala Ser Leu Leu Gly Ser Gln His Trp His Val 
145                 150                 155                 160 


Leu Leu Ile Ile Ser Ile Pro Ser 
                165             


<210>  728
<211>  618
<212>  PRT
<213>  Homo Sapiens

<400>  728

Met Ala Ser Arg Gly Ala Arg Gln Arg Leu Lys Gly Ser Gly Ala Ser 
1               5                   10                  15      


Ser Gly Asp Thr Ala Pro Ala Ala Asp Lys Leu Arg Glu Leu Leu Gly 
            20                  25                  30          


Ser Arg Glu Ala Gly Gly Ala Glu His Arg Thr Glu Leu Ser Gly Asn 
        35                  40                  45              


Lys Ala Gly Gln Val Trp Ala Pro Glu Gly Ser Thr Ala Phe Lys Cys 
    50                  55                  60                  


Leu Leu Ser Ala Arg Leu Cys Ala Ala Leu Leu Ser Asn Ile Ser Asp 
65                  70                  75                  80  


Cys Asp Glu Thr Phe Asn Tyr Trp Glu Pro Thr His Tyr Leu Ile Tyr 
                85                  90                  95      


Gly Glu Gly Phe Gln Thr Trp Glu Tyr Ser Pro Ala Tyr Ala Ile Arg 
            100                 105                 110         


Ser Tyr Ala Tyr Leu Leu Leu His Ala Trp Pro Ala Ala Phe His Ala 
        115                 120                 125             


Arg Ile Leu Gln Thr Asn Lys Ile Leu Val Phe Tyr Phe Leu Arg Cys 
    130                 135                 140                 


Leu Leu Ala Phe Val Ser Cys Ile Cys Glu Leu Tyr Phe Tyr Lys Ala 
145                 150                 155                 160 


Val Cys Lys Lys Phe Gly Leu His Val Ser Arg Met Met Leu Ala Phe 
                165                 170                 175     


Leu Val Leu Ser Thr Gly Met Phe Cys Ser Ser Ser Ala Phe Leu Pro 
            180                 185                 190         


Ser Ser Phe Cys Met Tyr Thr Thr Leu Ile Ala Met Thr Gly Trp Tyr 
        195                 200                 205             


Met Asp Lys Thr Ser Ile Ala Val Leu Gly Val Ala Ala Gly Ala Ile 
    210                 215                 220                 


Leu Gly Trp Pro Phe Ser Ala Ala Leu Gly Leu Pro Ile Ala Phe Asp 
225                 230                 235                 240 


Leu Leu Val Met Lys His Arg Trp Lys Ser Phe Phe His Trp Ser Leu 
                245                 250                 255     


Met Ala Leu Ile Leu Phe Leu Val Pro Val Val Val Ile Asp Ser Tyr 
            260                 265                 270         


Tyr Tyr Gly Lys Leu Val Ile Ala Pro Leu Asn Ile Val Leu Tyr Asn 
        275                 280                 285             


Val Phe Thr Pro His Gly Pro Asp Leu Tyr Gly Thr Glu Pro Trp Tyr 
    290                 295                 300                 


Phe Tyr Leu Ile Asn Gly Phe Leu Asn Phe Asn Val Ala Phe Ala Leu 
305                 310                 315                 320 


Ala Leu Leu Val Leu Pro Leu Thr Ser Leu Met Glu Tyr Leu Leu Gln 
                325                 330                 335     


Arg Phe His Val Gln Asn Leu Gly His Pro Tyr Trp Leu Thr Leu Ala 
            340                 345                 350         


Pro Met Tyr Ile Trp Phe Ile Ile Phe Phe Ile Gln Pro His Lys Glu 
        355                 360                 365             


Glu Arg Phe Leu Phe Pro Val Tyr Pro Leu Ile Cys Leu Cys Gly Ala 
    370                 375                 380                 


Val Ala Leu Ser Ala Leu Gln His Ser Phe Leu Tyr Phe Gln Lys Cys 
385                 390                 395                 400 


Tyr His Phe Val Phe Gln Arg Tyr Arg Leu Glu His Tyr Thr Val Thr 
                405                 410                 415     


Ser Asn Trp Leu Ala Leu Gly Thr Val Phe Leu Phe Gly Leu Leu Ser 
            420                 425                 430         


Phe Ser Arg Ser Val Ala Leu Phe Arg Gly Tyr His Gly Pro Leu Asp 
        435                 440                 445             


Leu Tyr Pro Glu Phe Tyr Arg Ile Ala Thr Asp Pro Thr Ile His Thr 
    450                 455                 460                 


Val Pro Glu Gly Arg Pro Val Asn Val Cys Val Gly Lys Glu Trp Tyr 
465                 470                 475                 480 


Arg Phe Pro Ser Ser Phe Leu Leu Pro Asp Asn Trp Gln Leu Gln Phe 
                485                 490                 495     


Ile Pro Ser Glu Phe Arg Gly Gln Leu Pro Lys Pro Phe Ala Glu Gly 
            500                 505                 510         


Pro Leu Ala Thr Arg Ile Val Pro Thr Asp Met Asn Asp Gln Asn Leu 
        515                 520                 525             


Glu Glu Pro Ser Arg Tyr Ile Asp Ile Ser Lys Cys His Tyr Leu Val 
    530                 535                 540                 


Asp Leu Asp Thr Met Arg Glu Thr Pro Arg Glu Pro Lys Tyr Ser Ser 
545                 550                 555                 560 


Asn Lys Glu Glu Trp Ile Ser Leu Ala Tyr Arg Pro Phe Leu Asp Ala 
                565                 570                 575     


Ser Arg Ser Ser Lys Leu Leu Arg Ala Phe Tyr Val Pro Phe Leu Ser 
            580                 585                 590         


Asp Gln Tyr Thr Val Tyr Val Asn Tyr Thr Ile Leu Lys Pro Arg Lys 
        595                 600                 605             


Ala Lys Gln Ile Arg Lys Lys Ser Gly Gly 
    610                 615             


<210>  729
<211>  611
<212>  PRT
<213>  Homo Sapiens

<400>  729

Met Ala Ser Arg Gly Ala Arg Gln Arg Leu Lys Gly Ser Gly Ala Ser 
1               5                   10                  15      


Ser Gly Asp Thr Ala Pro Ala Ala Asp Lys Leu Arg Glu Leu Leu Gly 
            20                  25                  30          


Ser Arg Glu Ala Gly Gly Ala Glu His Arg Thr Glu Leu Ser Gly Asn 
        35                  40                  45              


Lys Ala Gly Gln Val Trp Ala Pro Glu Gly Ser Thr Ala Phe Lys Cys 
    50                  55                  60                  


Leu Leu Ser Ala Arg Leu Cys Ala Ala Leu Leu Ser Asn Ile Ser Asp 
65                  70                  75                  80  


Cys Asp Glu Thr Phe Asn Tyr Trp Glu Pro Thr His Tyr Leu Ile Tyr 
                85                  90                  95      


Gly Glu Gly Phe Gln Thr Trp Glu Tyr Ser Pro Ala Tyr Ala Ile Arg 
            100                 105                 110         


Ser Tyr Ala Tyr Leu Leu Leu His Ala Trp Pro Ala Ala Phe His Ala 
        115                 120                 125             


Arg Ile Leu Gln Thr Asn Lys Ile Leu Val Phe Tyr Phe Leu Arg Cys 
    130                 135                 140                 


Leu Leu Ala Phe Val Ser Cys Ile Cys Glu Leu Tyr Phe Tyr Lys Ala 
145                 150                 155                 160 


Val Cys Lys Lys Phe Gly Leu His Val Ser Arg Met Met Leu Ala Phe 
                165                 170                 175     


Leu Val Leu Ser Thr Gly Met Phe Cys Ser Ser Ser Ala Phe Leu Pro 
            180                 185                 190         


Ser Ser Phe Cys Met Tyr Thr Thr Leu Ile Ala Met Thr Gly Trp Tyr 
        195                 200                 205             


Met Asp Lys Thr Ser Ile Ala Val Leu Gly Val Ala Ala Gly Ala Ile 
    210                 215                 220                 


Leu Gly Trp Pro Phe Ser Ala Ala Leu Gly Leu Pro Ile Ala Phe Asp 
225                 230                 235                 240 


Leu Leu Val Met Lys His Arg Trp Lys Ser Phe Phe His Trp Ser Leu 
                245                 250                 255     


Met Ala Leu Ile Leu Phe Leu Val Pro Val Val Val Ile Asp Ser Tyr 
            260                 265                 270         


Tyr Tyr Gly Lys Leu Val Ile Ala Pro Leu Asn Ile Val Leu Tyr Asn 
        275                 280                 285             


Val Phe Thr Pro His Gly Pro Asp Leu Tyr Gly Thr Glu Pro Trp Tyr 
    290                 295                 300                 


Phe Tyr Leu Ile Asn Gly Phe Leu Asn Phe Asn Val Ala Phe Ala Leu 
305                 310                 315                 320 


Ala Leu Leu Val Leu Pro Leu Thr Ser Leu Met Glu Tyr Leu Leu Gln 
                325                 330                 335     


Arg Phe His Val Gln Asn Leu Gly His Pro Tyr Trp Leu Thr Leu Ala 
            340                 345                 350         


Pro Met Tyr Ile Trp Phe Ile Ile Phe Phe Ile Gln Pro His Lys Glu 
        355                 360                 365             


Glu Arg Phe Leu Phe Pro Val Tyr Pro Leu Ile Cys Leu Cys Gly Ala 
    370                 375                 380                 


Val Ala Leu Ser Ala Leu Gln Lys Cys Tyr His Phe Val Phe Gln Arg 
385                 390                 395                 400 


Tyr Arg Leu Glu His Tyr Thr Val Thr Ser Asn Trp Leu Ala Leu Gly 
                405                 410                 415     


Thr Val Phe Leu Phe Gly Leu Leu Ser Phe Ser Arg Ser Val Ala Leu 
            420                 425                 430         


Phe Arg Gly Tyr His Gly Pro Leu Asp Leu Tyr Pro Glu Phe Tyr Arg 
        435                 440                 445             


Ile Ala Thr Asp Pro Thr Ile His Thr Val Pro Glu Gly Arg Pro Val 
    450                 455                 460                 


Asn Val Cys Val Gly Lys Glu Trp Tyr Arg Phe Pro Ser Ser Phe Leu 
465                 470                 475                 480 


Leu Pro Asp Asn Trp Gln Leu Gln Phe Ile Pro Ser Glu Phe Arg Gly 
                485                 490                 495     


Gln Leu Pro Lys Pro Phe Ala Glu Gly Pro Leu Ala Thr Arg Ile Val 
            500                 505                 510         


Pro Thr Asp Met Asn Asp Gln Asn Leu Glu Glu Pro Ser Arg Tyr Ile 
        515                 520                 525             


Asp Ile Ser Lys Cys His Tyr Leu Val Asp Leu Asp Thr Met Arg Glu 
    530                 535                 540                 


Thr Pro Arg Glu Pro Lys Tyr Ser Ser Asn Lys Glu Glu Trp Ile Ser 
545                 550                 555                 560 


Leu Ala Tyr Arg Pro Phe Leu Asp Ala Ser Arg Ser Ser Lys Leu Leu 
                565                 570                 575     


Arg Ala Phe Tyr Val Pro Phe Leu Ser Asp Gln Tyr Thr Val Tyr Val 
            580                 585                 590         


Asn Tyr Thr Ile Leu Lys Pro Arg Lys Ala Lys Gln Ile Arg Lys Lys 
        595                 600                 605             


Ser Gly Gly 
    610     


<210>  730
<211>  198
<212>  PRT
<213>  Homo Sapiens

<400>  730

Met Ala Ser Arg Gly Ala Arg Gln Arg Leu Lys Gly Ser Gly Ala Ser 
1               5                   10                  15      


Ser Gly Asp Thr Ala Pro Ala Ala Asp Lys Leu Arg Glu Leu Leu Gly 
            20                  25                  30          


Ser Arg Glu Ala Gly Gly Ala Glu His Arg Thr Glu Leu Ser Gly Asn 
        35                  40                  45              


Lys Ala Gly Gln Val Trp Ala Pro Glu Gly Ser Thr Ala Phe Lys Cys 
    50                  55                  60                  


Leu Leu Ser Ala Arg Leu Cys Ala Ala Leu Leu Ser Asn Ile Ser Asp 
65                  70                  75                  80  


Cys Asp Glu Thr Phe Asn Tyr Trp Glu Pro Thr His Tyr Leu Ile Tyr 
                85                  90                  95      


Gly Glu Gly Phe Gln Thr Trp Glu Tyr Ser Pro Ala Tyr Ala Ile Arg 
            100                 105                 110         


Ser Tyr Ala Tyr Leu Leu Leu His Ala Trp Pro Ala Ala Phe His Ala 
        115                 120                 125             


Arg Ile Leu Gln Thr Asn Lys Ile Leu Val Phe Tyr Phe Leu Arg Cys 
    130                 135                 140                 


Leu Leu Ala Phe Val Ser Cys Ile Cys Glu Leu Tyr Phe Tyr Lys Ala 
145                 150                 155                 160 


Val Cys Lys Lys Phe Gly Leu His Val Ser Arg Met Met Leu Ala Phe 
                165                 170                 175     


Leu Val Leu Ser Thr Gly Met Phe Cys Ser Ser Ser Val Tyr Pro Leu 
            180                 185                 190         


Pro Leu Ile Cys Trp Ser 
        195             


<210>  731
<211>  134
<212>  PRT
<213>  Homo Sapiens

<400>  731

Met Ala Ser Arg Gly Ala Arg Gln Arg Leu Lys Gly Ser Gly Ala Ser 
1               5                   10                  15      


Ser Gly Asp Thr Ala Pro Ala Ala Asp Lys Leu Arg Glu Leu Leu Gly 
            20                  25                  30          


Ser Arg Glu Ala Gly Gly Ala Glu His Arg Thr Glu Leu Ser Gly Asn 
        35                  40                  45              


Lys Ala Gly Gln Val Trp Ala Pro Glu Gly Ser Thr Ala Phe Lys Cys 
    50                  55                  60                  


Leu Leu Ser Ala Arg Leu Cys Ala Ala Leu Leu Ser Asn Ile Ser Asp 
65                  70                  75                  80  


Cys Asp Glu Thr Phe Asn Tyr Trp Glu Pro Val Asp Thr Leu Pro His 
                85                  90                  95      


Leu Trp Gly Arg Val Ser Asp Leu Gly Ile Phe Pro Ser Ile Cys His 
            100                 105                 110         


Ser Leu Leu Cys Leu Pro Val Ala Ser Cys Leu Ala Ser Cys Ile Ser 
        115                 120                 125             


Cys Lys Asn Ser Thr Asn 
    130                 


<210>  732
<211>  447
<212>  PRT
<213>  Homo Sapiens

<400>  732

Met Met Leu Ala Phe Leu Val Leu Ser Thr Gly Met Phe Cys Ser Ser 
1               5                   10                  15      


Ser Ala Phe Leu Pro Ser Ser Phe Cys Met Tyr Thr Thr Leu Ile Ala 
            20                  25                  30          


Met Thr Gly Trp Tyr Met Asp Lys Thr Ser Ile Ala Val Leu Gly Val 
        35                  40                  45              


Ala Ala Gly Ala Ile Leu Gly Trp Pro Phe Ser Ala Ala Leu Gly Leu 
    50                  55                  60                  


Pro Ile Ala Phe Asp Leu Leu Val Met Lys His Arg Trp Lys Ser Phe 
65                  70                  75                  80  


Phe His Trp Ser Leu Met Ala Leu Ile Leu Phe Leu Val Pro Val Val 
                85                  90                  95      


Val Ile Asp Ser Tyr Tyr Tyr Gly Lys Leu Val Ile Ala Pro Leu Asn 
            100                 105                 110         


Ile Val Leu Tyr Asn Val Phe Thr Pro His Gly Pro Asp Leu Tyr Gly 
        115                 120                 125             


Thr Glu Pro Trp Tyr Phe Tyr Leu Ile Asn Gly Phe Leu Asn Phe Asn 
    130                 135                 140                 


Val Ala Phe Ala Leu Ala Leu Leu Val Leu Pro Leu Thr Ser Leu Met 
145                 150                 155                 160 


Glu Tyr Leu Leu Gln Arg Phe His Val Gln Asn Leu Gly His Pro Tyr 
                165                 170                 175     


Trp Leu Thr Leu Ala Pro Met Tyr Ile Trp Phe Ile Ile Phe Phe Ile 
            180                 185                 190         


Gln Pro His Lys Glu Glu Arg Phe Leu Phe Pro Val Tyr Pro Leu Ile 
        195                 200                 205             


Cys Leu Cys Gly Ala Val Ala Leu Ser Ala Leu Gln His Ser Phe Leu 
    210                 215                 220                 


Tyr Phe Gln Lys Cys Tyr His Phe Val Phe Gln Arg Tyr Arg Leu Glu 
225                 230                 235                 240 


His Tyr Thr Val Thr Ser Asn Trp Leu Ala Leu Gly Thr Val Phe Leu 
                245                 250                 255     


Phe Gly Leu Leu Ser Phe Ser Arg Ser Val Ala Leu Phe Arg Gly Tyr 
            260                 265                 270         


His Gly Pro Leu Asp Leu Tyr Pro Glu Phe Tyr Arg Ile Ala Thr Asp 
        275                 280                 285             


Pro Thr Ile His Thr Val Pro Glu Gly Arg Pro Val Asn Val Cys Val 
    290                 295                 300                 


Gly Lys Glu Trp Tyr Arg Phe Pro Ser Ser Phe Leu Leu Pro Asp Asn 
305                 310                 315                 320 


Trp Gln Leu Gln Phe Ile Pro Ser Glu Phe Arg Gly Gln Leu Pro Lys 
                325                 330                 335     


Pro Phe Ala Glu Gly Pro Leu Ala Thr Arg Ile Val Pro Thr Asp Met 
            340                 345                 350         


Asn Asp Gln Asn Leu Glu Glu Pro Ser Arg Tyr Ile Asp Ile Ser Lys 
        355                 360                 365             


Cys His Tyr Leu Val Asp Leu Asp Thr Met Arg Glu Thr Pro Arg Glu 
    370                 375                 380                 


Pro Lys Tyr Ser Ser Asn Lys Glu Glu Trp Ile Ser Leu Ala Tyr Arg 
385                 390                 395                 400 


Pro Phe Leu Asp Ala Ser Arg Ser Ser Lys Leu Leu Arg Ala Phe Tyr 
                405                 410                 415     


Val Pro Phe Leu Ser Asp Gln Tyr Thr Val Tyr Val Asn Tyr Thr Ile 
            420                 425                 430         


Leu Lys Pro Arg Lys Ala Lys Gln Ile Arg Lys Lys Ser Gly Gly 
        435                 440                 445         


<210>  733
<211>  440
<212>  PRT
<213>  Homo Sapiens

<400>  733

Met Met Leu Ala Phe Leu Val Leu Ser Thr Gly Met Phe Cys Ser Ser 
1               5                   10                  15      


Ser Ala Phe Leu Pro Ser Ser Phe Cys Met Tyr Thr Thr Leu Ile Ala 
            20                  25                  30          


Met Thr Gly Trp Tyr Met Asp Lys Thr Ser Ile Ala Val Leu Gly Val 
        35                  40                  45              


Ala Ala Gly Ala Ile Leu Gly Trp Pro Phe Ser Ala Ala Leu Gly Leu 
    50                  55                  60                  


Pro Ile Ala Phe Asp Leu Leu Val Met Lys His Arg Trp Lys Ser Phe 
65                  70                  75                  80  


Phe His Trp Ser Leu Met Ala Leu Ile Leu Phe Leu Val Pro Val Val 
                85                  90                  95      


Val Ile Asp Ser Tyr Tyr Tyr Gly Lys Leu Val Ile Ala Pro Leu Asn 
            100                 105                 110         


Ile Val Leu Tyr Asn Val Phe Thr Pro His Gly Pro Asp Leu Tyr Gly 
        115                 120                 125             


Thr Glu Pro Trp Tyr Phe Tyr Leu Ile Asn Gly Phe Leu Asn Phe Asn 
    130                 135                 140                 


Val Ala Phe Ala Leu Ala Leu Leu Val Leu Pro Leu Thr Ser Leu Met 
145                 150                 155                 160 


Glu Tyr Leu Leu Gln Arg Phe His Val Gln Asn Leu Gly His Pro Tyr 
                165                 170                 175     


Trp Leu Thr Leu Ala Pro Met Tyr Ile Trp Phe Ile Ile Phe Phe Ile 
            180                 185                 190         


Gln Pro His Lys Glu Glu Arg Phe Leu Phe Pro Val Tyr Pro Leu Ile 
        195                 200                 205             


Cys Leu Cys Gly Ala Val Ala Leu Ser Ala Leu Gln Lys Cys Tyr His 
    210                 215                 220                 


Phe Val Phe Gln Arg Tyr Arg Leu Glu His Tyr Thr Val Thr Ser Asn 
225                 230                 235                 240 


Trp Leu Ala Leu Gly Thr Val Phe Leu Phe Gly Leu Leu Ser Phe Ser 
                245                 250                 255     


Arg Ser Val Ala Leu Phe Arg Gly Tyr His Gly Pro Leu Asp Leu Tyr 
            260                 265                 270         


Pro Glu Phe Tyr Arg Ile Ala Thr Asp Pro Thr Ile His Thr Val Pro 
        275                 280                 285             


Glu Gly Arg Pro Val Asn Val Cys Val Gly Lys Glu Trp Tyr Arg Phe 
    290                 295                 300                 


Pro Ser Ser Phe Leu Leu Pro Asp Asn Trp Gln Leu Gln Phe Ile Pro 
305                 310                 315                 320 


Ser Glu Phe Arg Gly Gln Leu Pro Lys Pro Phe Ala Glu Gly Pro Leu 
                325                 330                 335     


Ala Thr Arg Ile Val Pro Thr Asp Met Asn Asp Gln Asn Leu Glu Glu 
            340                 345                 350         


Pro Ser Arg Tyr Ile Asp Ile Ser Lys Cys His Tyr Leu Val Asp Leu 
        355                 360                 365             


Asp Thr Met Arg Glu Thr Pro Arg Glu Pro Lys Tyr Ser Ser Asn Lys 
    370                 375                 380                 


Glu Glu Trp Ile Ser Leu Ala Tyr Arg Pro Phe Leu Asp Ala Ser Arg 
385                 390                 395                 400 


Ser Ser Lys Leu Leu Arg Ala Phe Tyr Val Pro Phe Leu Ser Asp Gln 
                405                 410                 415     


Tyr Thr Val Tyr Val Asn Tyr Thr Ile Leu Lys Pro Arg Lys Ala Lys 
            420                 425                 430         


Gln Ile Arg Lys Lys Ser Gly Gly 
        435                 440 


<210>  734
<211>  24
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  734

Xaa Glu Glu Trp Ile Ser Leu Ala Tyr Arg Pro Phe Leu Asp Ala Ser 
1               5                   10                  15      


Arg Val Ser Leu Cys Cys Pro Gly 
            20                  


<210>  735
<211>  35
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  735

Xaa Lys Tyr Ser Ser Asn Lys Glu Glu Trp Ile Ser Leu Ala Tyr Arg 
1               5                   10                  15      


Pro Phe Leu Asp Ala Ser Ser Phe Glu Gly Trp Lys Thr Lys Ile Thr 
            20                  25                  30          


Met Pro Val 
        35  


<210>  736
<211>  207
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  736

Xaa Thr Val Phe Leu Phe Gly Leu Leu Ser Phe Ser Arg Ser Val Ala 
1               5                   10                  15      


Leu Phe Arg Gly Tyr His Gly Pro Leu Asp Leu Tyr Pro Glu Phe Tyr 
            20                  25                  30          


Arg Ile Ala Thr Asp Pro Thr Ile His Thr Val Pro Glu Gly Arg Pro 
        35                  40                  45              


Val Asn Val Cys Val Gly Lys Glu Trp Tyr Arg Phe Pro Ser Ser Phe 
    50                  55                  60                  


Leu Leu Pro Asp Asn Trp Gln Leu Gln Phe Ile Pro Ser Glu Phe Arg 
65                  70                  75                  80  


Gly Gln Leu Pro Lys Pro Phe Ala Glu Gly Pro Leu Ala Thr Arg Ile 
                85                  90                  95      


Val Pro Thr Asp Met Asn Asp Gln Asn Leu Glu Glu Pro Ser Arg Tyr 
            100                 105                 110         


Ile Asp Ile Ser Lys Cys His Tyr Leu Val Asp Leu Asp Thr Met Arg 
        115                 120                 125             


Glu Thr Pro Arg Glu Pro Lys Tyr Ser Ser Asn Lys Glu Glu Trp Ile 
    130                 135                 140                 


Ser Leu Ala Tyr Arg Pro Phe Leu Asp Ala Ser Arg Ser Ser Lys Leu 
145                 150                 155                 160 


Leu Arg Ala Phe Tyr Val Pro Phe Leu Ser Asp Gln Tyr Thr Val Tyr 
                165                 170                 175     


Val Asn Tyr Thr Ile Leu Lys Pro Arg Lys Ala Lys Gln Ile Arg Lys 
            180                 185                 190         


Lys Ser Gly Asp Arg Arg Arg Ala Glu Pro Thr Tyr Arg Lys Asn 
        195                 200                 205         


<210>  737
<211>  111
<212>  PRT
<213>  Homo Sapiens

<400>  737

Met Arg Pro Leu Lys Pro Gly Ala Pro Leu Pro Ala Leu Phe Leu Leu 
1               5                   10                  15      


Ala Leu Ala Leu Ser Pro His Gly Ala His Gly Arg Pro Arg Gly Arg 
            20                  25                  30          


Arg Gly Ala Arg Val Thr Asp Lys Glu Pro Lys Pro Leu Leu Phe Leu 
        35                  40                  45              


Pro Ala Ala Gly Ala Gly Arg Thr Pro Ser Gly Ser Arg Ser Ala Glu 
    50                  55                  60                  


Ile Phe Pro Arg Asp Ser Asn Leu Lys Asp Lys Phe Ile Lys His Phe 
65                  70                  75                  80  


Thr Gly Pro Val Thr Phe Ser Pro Glu Cys Ser Lys His Phe His Arg 
                85                  90                  95      


Leu Tyr Tyr Asn Thr Arg Glu Cys Ser Thr Pro Ala Tyr Ile Ser 
            100                 105                 110     


<210>  738
<211>  129
<212>  PRT
<213>  Homo Sapiens

<400>  738

Met Arg Pro Leu Lys Pro Gly Ala Pro Leu Pro Ala Leu Phe Leu Leu 
1               5                   10                  15      


Ala Leu Ala Leu Ser Pro His Gly Ala His Gly Arg Pro Arg Gly Arg 
            20                  25                  30          


Arg Gly Ala Arg Val Thr Asp Lys Glu Pro Lys Pro Leu Leu Phe Leu 
        35                  40                  45              


Pro Ala Ala Gly Ala Gly Arg Thr Pro Ser Gly Ser Arg Ser Ala Glu 
    50                  55                  60                  


Ile Phe Pro Arg Asp Ser Asn Leu Lys Asp Lys Phe Ile Lys His Phe 
65                  70                  75                  80  


Thr Gly Pro Val Thr Phe Ser Pro Glu Cys Ser Lys His Phe His Arg 
                85                  90                  95      


Leu Tyr Tyr Asn Thr Arg Glu Cys Ser Thr Pro Ala Tyr Tyr Lys Arg 
            100                 105                 110         


Cys Ala Arg Leu Leu Thr Arg Leu Ala Val Ser Pro Leu Cys Ser Gln 
        115                 120                 125             


Thr 
    


<210>  739
<211>  59
<212>  PRT
<213>  Homo Sapiens

<400>  739

Met Lys Asp Lys Phe Leu Lys His Leu Thr Gly Pro Leu Tyr Phe Ser 
1               5                   10                  15      


Pro Lys Cys Ser Lys His Phe His Arg Leu Tyr His Asn Thr Arg Asp 
            20                  25                  30          


Cys Thr Ile Pro Ala Tyr Tyr Lys Arg Cys Ala Arg Leu Leu Thr Arg 
        35                  40                  45              


Leu Ala Val Ser Pro Val Cys Met Glu Asp Lys 
    50                  55                  


<210>  740
<211>  59
<212>  PRT
<213>  Homo Sapiens

<400>  740

Met Lys Asp Lys Phe Leu Lys His Leu Thr Gly Pro Leu Tyr Phe Ser 
1               5                   10                  15      


Pro Lys Cys Ser Lys His Phe His Arg Leu Tyr His Asn Thr Arg Asp 
            20                  25                  30          


Cys Thr Ile Pro Ala Tyr Tyr Lys Arg Cys Ala Arg Leu Leu Thr Arg 
        35                  40                  45              


Leu Ala Val Ser Pro Val Cys Met Glu Asp Lys 
    50                  55                  


<210>  741
<211>  60
<212>  PRT
<213>  Homo Sapiens

<400>  741

Met Lys Asp Lys Phe Leu Lys His Leu Thr Gly Pro Leu Tyr Phe Ser 
1               5                   10                  15      


Pro Lys Cys Ser Lys His Phe His Arg Leu Tyr His Asn Thr Arg Asp 
            20                  25                  30          


Cys Thr Ile Pro Ala Tyr Tyr Lys Arg Cys Ala Arg Leu Leu Thr Arg 
        35                  40                  45              


Leu Ala Val Ser Pro Val Cys Met Glu Asp Lys Gln 
    50                  55                  60  


<210>  742
<211>  151
<212>  PRT
<213>  Homo Sapiens

<400>  742

Met Arg Gly Pro Gly His Pro Leu Leu Leu Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Gly Ala Ala Gly Arg Gly Arg Gly Gly Ala Glu Pro Arg Glu Pro Ala 
            20                  25                  30          


Asp Gly Gln Ala Leu Leu Arg Leu Val Val Glu Leu Val Gln Glu Leu 
        35                  40                  45              


Arg Lys His His Ser Ala Glu His Lys Gly Leu Gln Leu Leu Gly Arg 
    50                  55                  60                  


Asp Cys Ala Leu Gly Arg Ala Glu Ala Ala Gly Leu Gly Pro Ser Pro 
65                  70                  75                  80  


Glu Gln Arg Val Glu Ile Val Pro Arg Asp Leu Arg Met Lys Asp Lys 
                85                  90                  95      


Phe Leu Lys His Leu Thr Gly Pro Leu Tyr Phe Ser Pro Lys Cys Ser 
            100                 105                 110         


Lys His Phe His Arg Leu Tyr His Asn Thr Arg Asp Cys Thr Ile Pro 
        115                 120                 125             


Ala Tyr Tyr Lys Arg Cys Ala Arg Leu Leu Thr Arg Leu Ala Val Ser 
    130                 135                 140                 


Pro Val Cys Met Glu Asp Lys 
145                 150     


<210>  743
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  743

Met Arg Gly Pro Gly His Pro Leu Leu Leu Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Gly Ala Ala Gly Arg Gly Arg Gly Gly Ala Glu Pro Arg Glu Pro Ala 
            20                  25                  30          


Asp Gly Gln Ala Leu Leu Arg Leu Val Val Glu Leu Val Gln Glu Leu 
        35                  40                  45              


Arg Lys His His Ser Ala Glu His Lys Gly Leu Gln Leu Leu Gly Arg 
    50                  55                  60                  


Asp Cys Ala Leu Gly Arg Ala Glu Ala Ala Gly Leu Gly Pro Ser Pro 
65                  70                  75                  80  


Glu Gln Arg Val Glu Ile Val Pro Arg Asp Leu Arg Met Lys Asp Lys 
                85                  90                  95      


Phe Leu Lys His Leu Thr Gly Pro Leu Tyr Phe Ser Pro Lys Cys Ser 
            100                 105                 110         


Lys His Phe His Arg Leu Tyr His Asn Thr Arg Asp Cys Thr Ile Pro 
        115                 120                 125             


Ala Tyr Tyr Lys Arg Cys Ala Arg Leu Leu Thr Arg Leu Ala Val Ser 
    130                 135                 140                 


Pro Val Cys Met Glu Asp Lys Gln 
145                 150         


<210>  744
<211>  91
<212>  PRT
<213>  Homo Sapiens

<400>  744

Met Arg Gly Pro Gly His Pro Leu Leu Leu Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Gly Pro Ser Pro Glu Gln Arg Val Glu Ile Val Pro Arg Asp Leu Arg 
            20                  25                  30          


Met Lys Asp Lys Phe Leu Lys His Leu Thr Gly Pro Leu Tyr Phe Ser 
        35                  40                  45              


Pro Lys Cys Ser Lys His Phe His Arg Leu Tyr His Asn Thr Arg Asp 
    50                  55                  60                  


Cys Thr Ile Pro Ala Tyr Tyr Lys Arg Cys Ala Arg Leu Leu Thr Arg 
65                  70                  75                  80  


Leu Ala Val Ser Pro Val Cys Met Glu Asp Lys 
                85                  90      


<210>  745
<211>  102
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  745

Xaa His His Ser Ala Glu His Lys Gly Leu Gln Leu Leu Gly Arg Asp 
1               5                   10                  15      


Cys Ala Leu Gly Arg Ala Glu Ala Ala Gly Leu Gly Pro Ser Pro Glu 
            20                  25                  30          


Gln Arg Val Glu Ile Val Pro Arg Asp Leu Arg Met Lys Asp Lys Phe 
        35                  40                  45              


Leu Lys His Leu Thr Gly Pro Leu Tyr Phe Ser Pro Lys Cys Ser Lys 
    50                  55                  60                  


His Phe His Arg Leu Tyr His Asn Thr Arg Asp Cys Thr Ile Pro Ala 
65                  70                  75                  80  


Tyr Tyr Lys Arg Cys Ala Arg Leu Leu Thr Arg Leu Ala Val Ser Pro 
                85                  90                  95      


Val Cys Met Glu Asp Lys 
            100         


<210>  746
<211>  112
<212>  PRT
<213>  Homo Sapiens

<400>  746

Ala Ala Ala Val Gly Ser Val Ala Thr Leu Ala Thr Glu Pro Gly Glu 
1               5                   10                  15      


Asp Ala Phe Arg Lys Leu Phe Arg Phe Tyr Arg Gln Ser Arg Pro Gly 
            20                  25                  30          


Thr Ala Asp Leu Glu Gly Val Ile Asp Phe Ser Ala Ala His Ala Ala 
        35                  40                  45              


Arg Gly Lys Gly Pro Gly Ala Gln Lys Val Ile Lys Ser Gln Leu Asn 
    50                  55                  60                  


Val Ser Ser Val Ser Glu Gln Asn Ala Tyr Arg Ala Gly Leu Gln Pro 
65                  70                  75                  80  


Val Ser Lys Trp Gln Ala Tyr Gly Leu Lys Gly Tyr Pro Gly Ile Lys 
                85                  90                  95      


Lys Arg Leu Asn Gly Asp Pro Glu Val Tyr Trp Arg Asn Cys Val Gly 
            100                 105                 110         


<210>  747
<211>  389
<212>  PRT
<213>  Homo Sapiens

<400>  747

Met Gly Lys Met Ala Ala Ala Val Gly Ser Val Ala Thr Leu Ala Thr 
1               5                   10                  15      


Glu Pro Gly Glu Asp Ala Phe Arg Lys Leu Phe Arg Phe Tyr Arg Gln 
            20                  25                  30          


Ser Arg Pro Gly Thr Ala Asp Leu Glu Gly Val Ile Asp Phe Ser Ala 
        35                  40                  45              


Ala His Ala Ala Arg Gly Lys Gly Pro Gly Ala Gln Lys Val Ile Lys 
    50                  55                  60                  


Ser Gln Leu Asn Val Ser Ser Val Ser Glu Gln Asn Ala Tyr Arg Ala 
65                  70                  75                  80  


Gly Leu Gln Pro Val Ser Lys Trp Gln Ala Tyr Gly Leu Lys Gly Tyr 
                85                  90                  95      


Pro Gly Phe Ile Phe Ile Pro Asn Pro Phe Leu Pro Gly Tyr Gln Trp 
            100                 105                 110         


His Trp Val Lys Gln Cys Leu Lys Leu Tyr Ser Gln Lys Pro Asn Val 
        115                 120                 125             


Cys Asn Leu Asp Lys His Met Ser Lys Glu Glu Thr Gln Asp Leu Trp 
    130                 135                 140                 


Glu Gln Ser Lys Glu Phe Leu Arg Tyr Lys Glu Ala Thr Lys Arg Arg 
145                 150                 155                 160 


Pro Arg Ser Leu Leu Glu Lys Leu Arg Trp Val Thr Val Gly Tyr His 
                165                 170                 175     


Tyr Asn Trp Asp Ser Lys Lys Tyr Ser Ala Asp His Tyr Thr Pro Phe 
            180                 185                 190         


Pro Ser Asp Leu Gly Phe Leu Ser Glu Gln Val Ala Ala Ala Cys Gly 
        195                 200                 205             


Phe Glu Asp Phe Arg Ala Glu Ala Gly Ile Leu Asn Tyr Tyr Arg Leu 
    210                 215                 220                 


Asp Ser Thr Leu Gly Ile His Val Asp Arg Ser Glu Leu Asp His Ser 
225                 230                 235                 240 


Lys Pro Leu Leu Ser Phe Ser Phe Gly Gln Ser Ala Ile Phe Leu Leu 
                245                 250                 255     


Gly Gly Leu Gln Arg Asp Glu Ala Pro Thr Ala Met Phe Met His Ser 
            260                 265                 270         


Gly Asp Ile Met Ile Met Ser Gly Phe Ser Arg Leu Leu Asn His Ala 
        275                 280                 285             


Val Pro Arg Val Leu Pro Asn Pro Glu Gly Glu Gly Leu Pro His Cys 
    290                 295                 300                 


Leu Glu Ala Pro Leu Pro Ala Val Leu Pro Arg Asp Ser Met Val Glu 
305                 310                 315                 320 


Pro Cys Ser Met Glu Asp Trp Gln Val Cys Ala Ser Tyr Leu Lys Thr 
                325                 330                 335     


Ala Arg Val Asn Met Thr Val Arg Gln Val Leu Ala Thr Asp Gln Asn 
            340                 345                 350         


Phe Pro Leu Glu Pro Ile Glu Asp Glu Lys Arg Asp Ile Ser Thr Glu 
        355                 360                 365             


Gly Phe Cys His Leu Asp Asp Gln Asn Ser Glu Val Lys Arg Ala Arg 
    370                 375                 380                 


Ile Asn Pro Asp Ser 
385                 


<210>  748
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  748

Met Gly Lys Met Ala Ala Ala Val Gly Ser Val Ala Thr Leu Ala Thr 
1               5                   10                  15      


Glu Pro Gly Glu Asp Ala Phe Arg Lys Leu Phe Arg Phe Tyr Arg Gln 
            20                  25                  30          


Ser Arg Pro Gly Thr Ala Asp Leu Glu Gly Val Ile Asp Phe Ser Ala 
        35                  40                  45              


Ala His Ala Ala Arg Gly Lys Gly Pro Gly Ala Gln Lys Val Ile Lys 
    50                  55                  60                  


Ser Gln Leu Asn Val Ser Ser Val Ser Glu Gln Asn Ala Tyr Arg Ala 
65                  70                  75                  80  


Gly Leu Gln Pro Val Ser Lys Trp Gln Ala Tyr Gly Leu Lys Gly Tyr 
                85                  90                  95      


Pro Gly Ile Lys Lys Arg Leu Asn Gly Asp Pro Glu Val Tyr Trp Arg 
            100                 105                 110         


Asn Cys Val Gly 
        115     


<210>  749
<211>  394
<212>  PRT
<213>  Homo Sapiens

<400>  749

Met Ala Ala Ala Ser Gly Tyr Thr Asp Leu Arg Glu Lys Leu Lys Ser 
1               5                   10                  15      


Met Thr Ser Arg Asp Asn Tyr Lys Ala Gly Ser Arg Glu Ala Ala Ala 
            20                  25                  30          


Ala Ala Ala Ala Ala Val Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        35                  40                  45              


Glu Pro Tyr Pro Val Ser Gly Ala Lys Arg Lys Tyr Gln Glu Asp Ser 
    50                  55                  60                  


Asp Pro Glu Arg Ser Asp Tyr Glu Glu Gln Gln Leu Gln Lys Glu Glu 
65                  70                  75                  80  


Glu Ala Arg Lys Val Lys Ser Gly Ile Arg Gln Met Arg Leu Phe Ser 
                85                  90                  95      


Gln Asp Glu Cys Ala Lys Ile Glu Ala Arg Ile Asp Glu Val Val Ser 
            100                 105                 110         


Arg Ala Glu Lys Gly Leu Tyr Asn Glu His Thr Val Asp Arg Ala Pro 
        115                 120                 125             


Leu Arg Asn Lys Tyr Phe Phe Gly Glu Gly Tyr Thr Tyr Gly Ala Gln 
    130                 135                 140                 


Leu Gln Lys Arg Gly Pro Gly Gln Glu Arg Leu Tyr Pro Pro Gly Asp 
145                 150                 155                 160 


Val Asp Glu Ile Pro Glu Trp Val His Gln Leu Val Ile Gln Lys Leu 
                165                 170                 175     


Val Glu His Arg Val Ile Pro Glu Gly Phe Val Asn Ser Ala Val Ile 
            180                 185                 190         


Asn Asp Tyr Gln Pro Gly Gly Cys Ile Val Ser His Val Asp Pro Ile 
        195                 200                 205             


His Ile Phe Glu Arg Pro Ile Val Ser Val Ser Phe Phe Ser Asp Ser 
    210                 215                 220                 


Ala Leu Cys Phe Gly Cys Lys Phe Gln Phe Lys Pro Ile Arg Val Ser 
225                 230                 235                 240 


Glu Pro Val Leu Ser Leu Pro Val Arg Arg Gly Ser Val Thr Val Leu 
                245                 250                 255     


Ser Gly Tyr Ala Ala Asp Glu Ile Thr His Cys Ile Arg Pro Gln Asp 
            260                 265                 270         


Ile Lys Glu Arg Arg Ala Val Ile Ile Leu Arg Lys Thr Arg Leu Asp 
        275                 280                 285             


Ala Pro Arg Leu Glu Thr Lys Ser Leu Ser Ser Ser Val Leu Pro Pro 
    290                 295                 300                 


Ser Tyr Ala Ser Asp Arg Leu Ser Gly Asn Asn Arg Asp Pro Ala Leu 
305                 310                 315                 320 


Lys Pro Lys Arg Ser His Arg Lys Ala Asp Pro Asp Ala Ala His Arg 
                325                 330                 335     


Pro Arg Ile Leu Glu Met Asp Lys Glu Glu Asn Arg Arg Ser Val Leu 
            340                 345                 350         


Leu Pro Thr His Arg Arg Arg Gly Ser Phe Ser Ser Glu Asn Tyr Trp 
        355                 360                 365             


Arg Lys Ser Tyr Glu Ser Ser Glu Asp Cys Ser Glu Ala Ala Gly Ser 
    370                 375                 380                 


Pro Ala Arg Lys Val Lys Met Arg Arg His 
385                 390                 


<210>  750
<211>  53
<212>  PRT
<213>  Homo Sapiens

<400>  750

Met Asp Lys Glu Glu Asn Arg Arg Ser Val Leu Leu Pro Thr His Arg 
1               5                   10                  15      


Arg Arg Gly Ser Phe Ser Ser Glu Asn Tyr Trp Arg Lys Ser Tyr Glu 
            20                  25                  30          


Ser Ser Glu Asp Cys Ser Glu Ala Ala Gly Ser Pro Ala Arg Lys Val 
        35                  40                  45              


Lys Met Arg Arg His 
    50              


<210>  751
<211>  528
<212>  PRT
<213>  Homo Sapiens

<400>  751

Met Gln Gly Pro Trp Val Leu Leu Leu Leu Gly Leu Arg Leu Gln Leu 
1               5                   10                  15      


Ser Leu Gly Val Ile Pro Ala Glu Glu Glu Asn Pro Ala Phe Trp Asn 
            20                  25                  30          


Arg Gln Ala Ala Glu Ala Leu Asp Ala Ala Lys Lys Leu Gln Pro Ile 
        35                  40                  45              


Gln Lys Val Ala Lys Asn Leu Ile Leu Phe Leu Gly Asp Gly Leu Gly 
    50                  55                  60                  


Val Pro Thr Val Thr Ala Thr Arg Ile Leu Lys Gly Gln Lys Asn Gly 
65                  70                  75                  80  


Lys Leu Gly Pro Glu Thr Pro Leu Ala Met Asp Arg Phe Pro Tyr Leu 
                85                  90                  95      


Ala Leu Ser Lys Thr Tyr Asn Val Asp Arg Gln Val Pro Asp Ser Ala 
            100                 105                 110         


Ala Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Phe Gln Thr 
        115                 120                 125             


Ile Gly Leu Ser Ala Ala Ala Arg Phe Asn Gln Cys Asn Thr Thr Arg 
    130                 135                 140                 


Gly Asn Glu Val Ile Ser Val Met Asn Arg Ala Lys Gln Ala Gly Lys 
145                 150                 155                 160 


Ser Val Gly Val Val Thr Thr Thr Arg Val Gln His Ala Ser Pro Ala 
                165                 170                 175     


Gly Thr Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp 
            180                 185                 190         


Met Pro Ala Ser Ala Arg Gln Glu Gly Cys Gln Asp Ile Ala Thr Gln 
        195                 200                 205             


Leu Ile Ser Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg Lys 
    210                 215                 220                 


Tyr Met Phe Pro Met Gly Thr Pro Asp Pro Glu Tyr Pro Ala Asp Ala 
225                 230                 235                 240 


Ser Gln Asn Gly Ile Arg Leu Asp Gly Lys Asn Leu Val Gln Glu Trp 
                245                 250                 255     


Leu Ala Lys His Gln Gly Ala Trp Tyr Val Trp Asn Arg Thr Glu Leu 
            260                 265                 270         


Met Gln Ala Ser Leu Asp Gln Ser Val Thr His Leu Met Gly Leu Phe 
        275                 280                 285             


Glu Pro Gly Asp Thr Lys Tyr Glu Ile His Arg Asp Pro Thr Leu Asp 
    290                 295                 300                 


Pro Ser Leu Met Glu Met Thr Glu Ala Ala Leu Arg Leu Leu Ser Arg 
305                 310                 315                 320 


Asn Pro Arg Gly Phe Tyr Leu Phe Val Glu Gly Gly Arg Ile Asp His 
                325                 330                 335     


Gly His His Glu Gly Val Ala Tyr Gln Ala Leu Thr Glu Ala Val Met 
            340                 345                 350         


Phe Asp Asp Ala Ile Glu Arg Ala Gly Gln Leu Thr Ser Glu Glu Asp 
        355                 360                 365             


Thr Leu Thr Leu Val Thr Ala Asp His Ser His Val Phe Ser Phe Gly 
    370                 375                 380                 


Gly Tyr Thr Leu Arg Gly Ser Ser Ile Phe Gly Leu Ala Pro Ser Lys 
385                 390                 395                 400 


Ala Gln Asp Ser Lys Ala Tyr Thr Ser Ile Leu Tyr Gly Asn Gly Pro 
                405                 410                 415     


Gly Tyr Val Phe Asn Ser Gly Val Arg Pro Asp Val Asn Glu Ser Glu 
            420                 425                 430         


Ser Gly Ser Pro Asp Tyr Gln Gln Gln Ala Ala Val Pro Leu Ser Ser 
        435                 440                 445             


Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ala Arg Gly Pro Gln 
    450                 455                 460                 


Ala His Leu Val His Gly Val Gln Glu Gln Ser Phe Val Ala His Val 
465                 470                 475                 480 


Met Ala Phe Ala Ala Cys Leu Glu Pro Tyr Thr Ala Cys Asp Leu Ala 
                485                 490                 495     


Pro Pro Ala Cys Thr Thr Asp Ala Ala His Pro Val Ala Ala Ser Leu 
            500                 505                 510         


Pro Leu Leu Ala Gly Thr Leu Leu Leu Leu Gly Ala Ser Ala Ala Pro 
        515                 520                 525             


<210>  752
<211>  50
<212>  PRT
<213>  Homo Sapiens

<400>  752

Met Gln Gly Pro Trp Val Leu Leu Leu Leu Gly Leu Arg Leu Gln Leu 
1               5                   10                  15      


Ser Leu Gly Val Ile Pro Gly Asn Glu Ala Pro Gln Ala Val Pro His 
            20                  25                  30          


Thr Gly His Pro Leu Ser Gln Ala Asp Leu Ile Ser Thr Leu Pro Leu 
        35                  40                  45              


Ala Ser 
    50  


<210>  753
<211>  469
<212>  PRT
<213>  Homo Sapiens

<400>  753

Met Phe Leu Gly Asp Gly Met Gly Val Ser Thr Val Thr Ala Ala Arg 
1               5                   10                  15      


Ile Leu Lys Gly Gln Leu His His Asn Pro Gly Glu Glu Thr Arg Leu 
            20                  25                  30          


Glu Met Asp Lys Phe Pro Phe Val Ala Leu Ser Lys Thr Tyr Asn Thr 
        35                  40                  45              


Asn Ala Gln Val Pro Asp Ser Ala Gly Thr Ala Thr Ala Tyr Leu Cys 
    50                  55                  60                  


Gly Val Lys Ala Asn Glu Gly Thr Val Gly Val Ser Ala Ala Thr Glu 
65                  70                  75                  80  


Arg Ser Arg Cys Asn Thr Thr Gln Gly Asn Glu Val Thr Ser Ile Leu 
                85                  90                  95      


Arg Trp Ala Lys Asp Ala Gly Lys Ser Val Gly Ile Val Thr Thr Thr 
            100                 105                 110         


Arg Val Asn His Ala Thr Pro Ser Ala Ala Tyr Ala His Ser Ala Asp 
        115                 120                 125             


Arg Asp Trp Tyr Ser Asp Asn Glu Met Pro Pro Glu Ala Leu Ser Gln 
    130                 135                 140                 


Gly Cys Lys Asp Ile Ala Tyr Gln Leu Met His Asn Ile Arg Asp Ile 
145                 150                 155                 160 


Asp Val Ile Met Gly Gly Gly Arg Lys Tyr Met Tyr Pro Lys Asn Lys 
                165                 170                 175     


Thr Asp Val Glu Tyr Glu Ser Asp Glu Lys Ala Arg Gly Thr Arg Leu 
            180                 185                 190         


Asp Gly Leu Asp Leu Val Asp Thr Trp Lys Ser Phe Lys Pro Arg Tyr 
        195                 200                 205             


Lys His Ser His Phe Ile Trp Asn Arg Thr Glu Leu Leu Thr Leu Asp 
    210                 215                 220                 


Pro His Asn Val Asp Tyr Leu Leu Gly Leu Phe Glu Pro Gly Asp Met 
225                 230                 235                 240 


Gln Tyr Glu Leu Asn Arg Asn Asn Val Thr Asp Pro Ser Leu Ser Glu 
                245                 250                 255     


Met Val Val Val Ala Ile Gln Ile Leu Arg Lys Asn Pro Lys Gly Phe 
            260                 265                 270         


Phe Leu Leu Val Glu Gly Gly Arg Ile Asp His Gly His His Glu Gly 
        275                 280                 285             


Lys Ala Lys Gln Ala Leu His Glu Ala Val Glu Met Asp Arg Ala Ile 
    290                 295                 300                 


Gly Gln Ala Gly Ser Leu Thr Ser Ser Glu Asp Thr Leu Thr Val Val 
305                 310                 315                 320 


Thr Ala Asp His Ser His Val Phe Thr Phe Gly Gly Tyr Thr Pro Arg 
                325                 330                 335     


Gly Asn Ser Ile Phe Gly Leu Ala Pro Met Leu Ser Asp Thr Asp Lys 
            340                 345                 350         


Lys Pro Phe Thr Ala Ile Leu Tyr Gly Asn Gly Pro Gly Tyr Lys Val 
        355                 360                 365             


Val Gly Gly Glu Arg Glu Asn Val Ser Met Val Asp Tyr Ala His Asn 
    370                 375                 380                 


Asn Tyr Gln Ala Gln Ser Ala Val Pro Leu Arg His Glu Thr His Gly 
385                 390                 395                 400 


Gly Glu Asp Val Ala Val Phe Ser Lys Gly Pro Met Ala His Leu Leu 
                405                 410                 415     


His Gly Val His Glu Gln Asn Tyr Val Pro His Val Met Ala Tyr Ala 
            420                 425                 430         


Ala Cys Ile Gly Ala Asn Leu Gly His Cys Ala Pro Ala Ser Ser Ala 
        435                 440                 445             


Gly Ser Leu Ala Ala Gly Pro Leu Leu Leu Ala Leu Ala Leu Tyr Pro 
    450                 455                 460                 


Leu Ser Val Leu Phe 
465                 


<210>  754
<211>  524
<212>  PRT
<213>  Homo Sapiens

<400>  754

Met Ile Ser Pro Phe Leu Val Leu Ala Ile Gly Thr Cys Leu Thr Asn 
1               5                   10                  15      


Ser Leu Val Pro Glu Lys Glu Lys Asp Pro Lys Tyr Trp Arg Asp Gln 
            20                  25                  30          


Ala Gln Glu Thr Leu Lys Tyr Ala Leu Glu Leu Gln Lys Leu Asn Thr 
        35                  40                  45              


Asn Val Ala Lys Asn Val Ile Met Phe Leu Gly Asp Gly Met Gly Val 
    50                  55                  60                  


Ser Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Leu His His Asn 
65                  70                  75                  80  


Pro Gly Glu Glu Thr Arg Leu Glu Met Asp Lys Phe Pro Phe Val Ala 
                85                  90                  95      


Leu Ser Lys Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp Ser Ala Gly 
            100                 105                 110         


Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Glu Gly Thr Val 
        115                 120                 125             


Gly Val Ser Ala Ala Thr Glu Arg Ser Arg Cys Asn Thr Thr Gln Gly 
    130                 135                 140                 


Asn Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Ala Gly Lys Ser 
145                 150                 155                 160 


Val Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala 
                165                 170                 175     


Ala Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met 
            180                 185                 190         


Pro Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu 
        195                 200                 205             


Met His Asn Ile Arg Asp Ile Asp Val Ile Met Gly Gly Gly Arg Lys 
    210                 215                 220                 


Tyr Met Tyr Pro Lys Asn Lys Thr Asp Val Glu Tyr Glu Ser Asp Glu 
225                 230                 235                 240 


Lys Ala Arg Gly Thr Arg Leu Asp Gly Leu Asp Leu Val Asp Thr Trp 
                245                 250                 255     


Lys Ser Phe Lys Pro Arg Tyr Lys His Ser His Phe Ile Trp Asn Arg 
            260                 265                 270         


Thr Glu Leu Leu Thr Leu Asp Pro His Asn Val Asp Tyr Leu Leu Gly 
        275                 280                 285             


Leu Phe Glu Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Asn Val 
    290                 295                 300                 


Thr Asp Pro Ser Leu Ser Glu Met Val Val Val Ala Ile Gln Ile Leu 
305                 310                 315                 320 


Arg Lys Asn Pro Lys Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile 
                325                 330                 335     


Asp His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala 
            340                 345                 350         


Val Glu Met Asp Arg Ala Ile Gly Gln Ala Gly Ser Leu Thr Ser Ser 
        355                 360                 365             


Glu Asp Thr Leu Thr Val Val Thr Ala Asp His Ser His Val Phe Thr 
    370                 375                 380                 


Phe Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro 
385                 390                 395                 400 


Met Leu Ser Asp Thr Asp Lys Lys Pro Phe Thr Ala Ile Leu Tyr Gly 
                405                 410                 415     


Asn Gly Pro Gly Tyr Lys Val Val Gly Gly Glu Arg Glu Asn Val Ser 
            420                 425                 430         


Met Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro 
        435                 440                 445             


Leu Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ser Lys 
    450                 455                 460                 


Gly Pro Met Ala His Leu Leu His Gly Val His Glu Gln Asn Tyr Val 
465                 470                 475                 480 


Pro His Val Met Ala Tyr Ala Ala Cys Ile Gly Ala Asn Leu Gly His 
                485                 490                 495     


Cys Ala Pro Ala Ser Ser Ala Gly Ser Leu Ala Ala Gly Pro Leu Leu 
            500                 505                 510         


Leu Ala Leu Ala Leu Tyr Pro Leu Ser Val Leu Phe 
        515                 520                 


<210>  755
<211>  524
<212>  PRT
<213>  Homo Sapiens

<400>  755

Met Ile Ser Pro Phe Leu Val Leu Ala Ile Gly Thr Cys Leu Thr Asn 
1               5                   10                  15      


Ser Leu Val Pro Glu Lys Glu Lys Asp Pro Lys Tyr Trp Arg Asp Gln 
            20                  25                  30          


Ala Gln Glu Thr Leu Lys Tyr Ala Leu Glu Leu Gln Lys Leu Asn Thr 
        35                  40                  45              


Asn Val Ala Lys Asn Val Ile Met Phe Leu Gly Asp Gly Met Gly Val 
    50                  55                  60                  


Ser Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Leu His His Asn 
65                  70                  75                  80  


Pro Gly Glu Glu Thr Arg Leu Glu Met Asp Lys Phe Pro Phe Val Ala 
                85                  90                  95      


Leu Ser Lys Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp Ser Ala Gly 
            100                 105                 110         


Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Glu Gly Thr Val 
        115                 120                 125             


Gly Val Ser Ala Ala Thr Glu Arg Ser Arg Cys Asn Thr Thr Gln Gly 
    130                 135                 140                 


Asn Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Ala Gly Lys Ser 
145                 150                 155                 160 


Val Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala 
                165                 170                 175     


Ala Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met 
            180                 185                 190         


Pro Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu 
        195                 200                 205             


Met His Asn Ile Arg Asp Ile Asp Val Ile Met Gly Gly Gly Arg Lys 
    210                 215                 220                 


Tyr Met Tyr Pro Lys Asn Lys Thr Asp Val Glu Tyr Glu Ser Asp Glu 
225                 230                 235                 240 


Lys Ala Arg Gly Thr Arg Leu Asp Gly Leu Asp Leu Val Asp Thr Trp 
                245                 250                 255     


Lys Ser Phe Lys Pro Arg Tyr Lys His Ser His Phe Ile Trp Asn Arg 
            260                 265                 270         


Thr Glu Leu Leu Thr Leu Asp Pro His Asn Val Asp Tyr Leu Leu Gly 
        275                 280                 285             


Leu Phe Glu Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Asn Val 
    290                 295                 300                 


Thr Asp Pro Ser Leu Ser Glu Met Val Val Val Ala Ile Gln Ile Leu 
305                 310                 315                 320 


Arg Lys Asn Pro Lys Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile 
                325                 330                 335     


Asp His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala 
            340                 345                 350         


Val Glu Met Asp Arg Ala Ile Gly Gln Ala Gly Ser Leu Thr Ser Ser 
        355                 360                 365             


Glu Asp Thr Leu Thr Val Val Thr Ala Asp His Ser His Val Phe Thr 
    370                 375                 380                 


Phe Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro 
385                 390                 395                 400 


Met Leu Ser Asp Thr Asp Lys Lys Pro Phe Thr Ala Ile Leu Tyr Gly 
                405                 410                 415     


Asn Gly Pro Gly Tyr Lys Val Val Gly Gly Glu Arg Glu Asn Val Ser 
            420                 425                 430         


Met Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro 
        435                 440                 445             


Leu Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ser Lys 
    450                 455                 460                 


Gly Pro Met Ala His Leu Leu His Gly Val His Glu Gln Asn Tyr Val 
465                 470                 475                 480 


Pro His Val Met Ala Tyr Ala Ala Cys Ile Gly Ala Asn Leu Gly His 
                485                 490                 495     


Cys Ala Pro Ala Ser Ser Ala Gly Ser Leu Ala Ala Gly Pro Leu Leu 
            500                 505                 510         


Leu Ala Leu Ala Leu Tyr Pro Leu Ser Val Leu Phe 
        515                 520                 


<210>  756
<211>  447
<212>  PRT
<213>  Homo Sapiens

<400>  756

Met Pro Trp Ser Phe Arg Ser Ser Thr Pro Thr Trp Leu Arg Met Ser 
1               5                   10                  15      


Ser Cys Ser Trp Glu Met Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp 
            20                  25                  30          


Ser Ala Gly Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Glu 
        35                  40                  45              


Gly Thr Val Gly Val Ser Ala Ala Thr Glu Arg Ser Arg Cys Asn Thr 
    50                  55                  60                  


Thr Gln Gly Asn Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Ala 
65                  70                  75                  80  


Gly Lys Ser Val Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr 
                85                  90                  95      


Pro Ser Ala Ala Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp 
            100                 105                 110         


Asn Glu Met Pro Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala 
        115                 120                 125             


Tyr Gln Leu Met His Asn Ile Arg Asp Ile Asp Val Ile Met Gly Gly 
    130                 135                 140                 


Gly Arg Lys Tyr Met Tyr Pro Lys Asn Lys Thr Asp Val Glu Tyr Glu 
145                 150                 155                 160 


Ser Asp Glu Lys Ala Arg Gly Thr Arg Leu Asp Gly Leu Asp Leu Val 
                165                 170                 175     


Asp Thr Trp Lys Ser Phe Lys Pro Arg Tyr Lys His Ser His Phe Ile 
            180                 185                 190         


Trp Asn Arg Thr Glu Leu Leu Thr Leu Asp Pro His Asn Val Asp Tyr 
        195                 200                 205             


Leu Leu Gly Leu Phe Glu Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg 
    210                 215                 220                 


Asn Asn Val Thr Asp Pro Ser Leu Ser Glu Met Val Val Val Ala Ile 
225                 230                 235                 240 


Gln Ile Leu Arg Lys Asn Pro Lys Gly Phe Phe Leu Leu Val Glu Gly 
                245                 250                 255     


Gly Arg Ile Asp His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu 
            260                 265                 270         


His Glu Ala Val Glu Met Asp Arg Ala Ile Gly Gln Ala Gly Ser Leu 
        275                 280                 285             


Thr Ser Ser Glu Asp Thr Leu Thr Val Val Thr Ala Asp His Ser His 
    290                 295                 300                 


Val Phe Thr Phe Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly 
305                 310                 315                 320 


Leu Ala Pro Met Leu Ser Asp Thr Asp Lys Lys Pro Phe Thr Ala Ile 
                325                 330                 335     


Leu Tyr Gly Asn Gly Pro Gly Tyr Lys Val Val Gly Gly Glu Arg Glu 
            340                 345                 350         


Asn Val Ser Met Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser 
        355                 360                 365             


Ala Val Pro Leu Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val 
    370                 375                 380                 


Phe Ser Lys Gly Pro Met Ala His Leu Leu His Gly Val His Glu Gln 
385                 390                 395                 400 


Asn Tyr Val Pro His Val Met Ala Tyr Ala Ala Cys Ile Gly Ala Asn 
                405                 410                 415     


Leu Gly His Cys Ala Pro Ala Ser Ser Ala Gly Ser Leu Ala Ala Gly 
            420                 425                 430         


Pro Leu Leu Leu Ala Leu Ala Leu Tyr Pro Leu Ser Val Leu Phe 
        435                 440                 445         


<210>  757
<211>  216
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  757

Xaa His Ser His Phe Ile Trp Asn Arg Thr Glu Leu Leu Thr Leu Asp 
1               5                   10                  15      


Pro His Asn Val Asp Tyr Leu Leu Gly Gly Arg Ile Asp His Gly His 
            20                  25                  30          


His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala Val Glu Met Asp 
        35                  40                  45              


Arg Ala Ile Gly Gln Ala Gly Ser Leu Thr Ser Ser Glu Asp Thr Leu 
    50                  55                  60                  


Thr Val Val Thr Ala Asp His Ser His Val Phe Thr Phe Gly Gly Tyr 
65                  70                  75                  80  


Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro Met Leu Ser Asp 
                85                  90                  95      


Thr Asp Lys Lys Pro Phe Thr Ala Ile Leu Tyr Gly Asn Gly Pro Gly 
            100                 105                 110         


Tyr Lys Val Val Gly Gly Glu Arg Glu Asn Val Ser Met Val Asp Tyr 
        115                 120                 125             


Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro Leu Arg His Glu 
    130                 135                 140                 


Thr His Gly Gly Glu Asp Val Ala Val Phe Ser Lys Gly Pro Met Ala 
145                 150                 155                 160 


His Leu Leu His Gly Val His Glu Gln Asn Tyr Val Pro His Val Met 
                165                 170                 175     


Ala Tyr Ala Ala Cys Ile Gly Ala Asn Leu Gly His Cys Ala Pro Ala 
            180                 185                 190         


Ser Ser Ala Gly Ser Leu Ala Ala Gly Pro Leu Leu Leu Ala Leu Ala 
        195                 200                 205             


Leu Tyr Pro Leu Ser Val Leu Phe 
    210                 215     


<210>  758
<211>  535
<212>  PRT
<213>  Homo Sapiens

<400>  758

Met Leu Gly Pro Cys Met Leu Leu Leu Leu Leu Leu Leu Gly Leu Arg 
1               5                   10                  15      


Leu Gln Leu Ser Leu Gly Ile Ile Pro Val Glu Glu Glu Asn Pro Asp 
            20                  25                  30          


Phe Trp Asn Arg Glu Ala Ala Glu Ala Leu Gly Ala Ala Lys Lys Leu 
        35                  40                  45              


Gln Pro Ala Gln Thr Ala Ala Lys Asn Leu Ile Ile Phe Leu Gly Asp 
    50                  55                  60                  


Gly Met Gly Val Ser Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln 
65                  70                  75                  80  


Lys Lys Asp Lys Leu Gly Pro Glu Ile Pro Leu Ala Met Asp Arg Phe 
                85                  90                  95      


Pro Tyr Val Ala Leu Ser Lys Thr Tyr Asn Val Asp Lys His Val Pro 
            100                 105                 110         


Asp Ser Gly Ala Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Gly Asn 
        115                 120                 125             


Phe Gln Thr Ile Gly Leu Ser Ala Ala Ala Arg Phe Asn Gln Cys Asn 
    130                 135                 140                 


Thr Thr Arg Gly Asn Glu Val Ile Ser Val Met Asn Arg Ala Lys Lys 
145                 150                 155                 160 


Ala Gly Lys Ser Val Gly Val Val Thr Thr Thr Arg Val Gln His Ala 
                165                 170                 175     


Ser Pro Ala Gly Thr Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser 
            180                 185                 190         


Asp Ala Asp Val Pro Ala Ser Ala Arg Gln Glu Gly Cys Gln Asp Ile 
        195                 200                 205             


Ala Thr Gln Leu Ile Ser Asn Met Asp Ile Asp Val Ile Leu Gly Gly 
    210                 215                 220                 


Gly Arg Lys Tyr Met Phe Arg Met Gly Thr Pro Asp Pro Glu Tyr Pro 
225                 230                 235                 240 


Asp Asp Tyr Ser Gln Gly Gly Thr Arg Leu Asp Gly Lys Asn Leu Val 
                245                 250                 255     


Gln Glu Trp Leu Ala Lys Arg Gln Gly Ala Arg Tyr Val Trp Asn Arg 
            260                 265                 270         


Thr Glu Leu Met Gln Ala Ser Leu Asp Pro Ser Val Thr His Leu Met 
        275                 280                 285             


Gly Leu Phe Glu Pro Gly Asp Met Lys Tyr Glu Ile His Arg Asp Ser 
    290                 295                 300                 


Thr Leu Asp Pro Ser Leu Met Glu Met Thr Glu Ala Ala Leu Arg Leu 
305                 310                 315                 320 


Leu Ser Arg Asn Pro Arg Gly Phe Phe Leu Phe Val Glu Gly Gly Arg 
                325                 330                 335     


Ile Asp His Gly His His Glu Ser Arg Ala Tyr Arg Ala Leu Thr Glu 
            340                 345                 350         


Thr Ile Met Phe Asp Asp Ala Ile Glu Arg Ala Gly Gln Leu Thr Ser 
        355                 360                 365             


Glu Glu Asp Thr Leu Ser Leu Val Thr Ala Asp His Ser His Val Phe 
    370                 375                 380                 


Ser Phe Gly Gly Tyr Pro Leu Arg Gly Ser Ser Ile Phe Gly Leu Ala 
385                 390                 395                 400 


Pro Gly Lys Ala Arg Asp Arg Lys Ala Tyr Thr Val Leu Leu Tyr Gly 
                405                 410                 415     


Asn Gly Pro Gly Tyr Val Leu Lys Asp Gly Ala Arg Pro Asp Val Thr 
            420                 425                 430         


Glu Ser Glu Ser Gly Ser Pro Glu Tyr Arg Gln Gln Ser Ala Val Pro 
        435                 440                 445             


Leu Asp Glu Glu Thr His Ala Gly Glu Asp Val Ala Val Phe Ala Arg 
    450                 455                 460                 


Gly Pro Gln Ala His Leu Val His Gly Val Gln Glu Gln Thr Phe Ile 
465                 470                 475                 480 


Ala His Val Met Ala Phe Ala Ala Cys Leu Glu Pro Tyr Thr Ala Cys 
                485                 490                 495     


Asp Leu Ala Pro Pro Ala Gly Thr Thr Asp Ala Ala His Pro Gly Arg 
            500                 505                 510         


Ser Val Val Pro Ala Leu Leu Pro Leu Leu Ala Gly Thr Leu Leu Leu 
        515                 520                 525             


Leu Glu Thr Ala Thr Ala Pro 
    530                 535 


<210>  759
<211>  532
<212>  PRT
<213>  Homo Sapiens

<400>  759

Met Gln Gly Pro Trp Val Leu Leu Leu Leu Gly Leu Arg Leu Gln Leu 
1               5                   10                  15      


Ser Leu Gly Ile Ile Pro Val Glu Glu Glu Asn Pro Asp Phe Trp Asn 
            20                  25                  30          


Arg Gln Ala Ala Glu Ala Leu Gly Ala Ala Lys Lys Leu Gln Pro Ala 
        35                  40                  45              


Gln Thr Ala Ala Lys Asn Leu Ile Ile Phe Leu Gly Asp Gly Met Gly 
    50                  55                  60                  


Val Ser Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Lys Lys Asp 
65                  70                  75                  80  


Lys Leu Gly Pro Glu Thr Phe Leu Ala Met Asp Arg Phe Pro Tyr Val 
                85                  90                  95      


Ala Leu Ser Lys Thr Tyr Ser Val Asp Lys His Val Pro Asp Ser Gly 
            100                 105                 110         


Ala Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Gly Asn Phe Gln Thr 
        115                 120                 125             


Ile Gly Leu Ser Ala Ala Ala Arg Phe Asn Gln Cys Asn Thr Thr Arg 
    130                 135                 140                 


Gly Asn Glu Val Ile Ser Val Met Asn Arg Ala Lys Lys Ala Gly Lys 
145                 150                 155                 160 


Ser Val Gly Val Val Thr Thr Thr Arg Val Gln His Ala Ser Pro Ala 
                165                 170                 175     


Gly Ala Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp 
            180                 185                 190         


Val Pro Ala Ser Ala Arg Gln Glu Gly Cys Gln Asp Ile Ala Thr Gln 
        195                 200                 205             


Leu Ile Ser Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg Lys 
    210                 215                 220                 


Tyr Met Phe Pro Met Gly Thr Pro Asp Pro Glu Tyr Pro Asp Asp Tyr 
225                 230                 235                 240 


Ser Gln Gly Gly Thr Arg Leu Asp Gly Lys Asn Leu Val Gln Glu Trp 
                245                 250                 255     


Leu Ala Lys His Gln Gly Ala Arg Tyr Val Trp Asn Arg Thr Glu Leu 
            260                 265                 270         


Leu Gln Ala Ser Leu Asp Pro Ser Val Thr His Leu Met Gly Leu Phe 
        275                 280                 285             


Glu Pro Gly Asp Met Lys Tyr Glu Ile His Arg Asp Ser Thr Leu Asp 
    290                 295                 300                 


Pro Ser Leu Met Glu Met Thr Glu Ala Ala Leu Leu Leu Leu Ser Arg 
305                 310                 315                 320 


Asn Pro Arg Gly Phe Phe Leu Phe Val Glu Gly Gly Arg Ile Asp His 
                325                 330                 335     


Gly His His Glu Ser Arg Ala Tyr Arg Ala Leu Thr Glu Thr Ile Met 
            340                 345                 350         


Phe Asp Asp Ala Ile Glu Arg Ala Gly Gln Leu Thr Ser Glu Glu Asp 
        355                 360                 365             


Thr Leu Ser Leu Val Thr Ala Asp His Ser His Val Phe Ser Phe Gly 
    370                 375                 380                 


Gly Tyr Pro Leu Arg Gly Ser Ser Ile Phe Gly Leu Ala Pro Gly Lys 
385                 390                 395                 400 


Ala Arg Asp Arg Lys Ala Tyr Thr Val Leu Leu Tyr Gly Asn Gly Pro 
                405                 410                 415     


Gly Tyr Val Leu Lys Asp Gly Ala Arg Pro Asp Val Thr Glu Ser Glu 
            420                 425                 430         


Ser Gly Ser Pro Glu Tyr Arg Gln Gln Ser Ala Val Pro Leu Asp Gly 
        435                 440                 445             


Glu Thr His Ala Gly Glu Asp Val Ala Val Phe Ala Arg Gly Pro Gln 
    450                 455                 460                 


Ala His Leu Val His Gly Val Gln Glu Gln Thr Phe Ile Ala His Val 
465                 470                 475                 480 


Met Ala Phe Ala Ala Cys Leu Glu Pro Tyr Thr Ala Cys Asp Leu Ala 
                485                 490                 495     


Pro Arg Ala Gly Thr Thr Asp Ala Ala His Pro Gly Pro Ser Val Val 
            500                 505                 510         


Pro Ala Leu Leu Pro Leu Leu Ala Gly Thr Leu Leu Leu Leu Gly Thr 
        515                 520                 525             


Ala Thr Ala Pro 
    530         


<210>  760
<211>  432
<212>  PRT
<213>  Homo Sapiens

<400>  760

Met Ser Ala Ser Lys Ile Pro Leu Phe Lys Met Lys Asp Leu Ile Leu 
1               5                   10                  15      


Ile Leu Cys Leu Leu Glu Met Ser Phe Ala Val Pro Phe Phe Pro Gln 
            20                  25                  30          


Gln Ser Gly Thr Pro Gly Met Ala Ser Leu Ser Leu Glu Thr Met Arg 
        35                  40                  45              


Gln Leu Gly Ser Leu Gln Arg Leu Asn Thr Leu Ser Gln Tyr Ser Arg 
    50                  55                  60                  


Tyr Gly Phe Gly Lys Ser Phe Asn Ser Leu Trp Met His Gly Leu Leu 
65                  70                  75                  80  


Pro Pro His Ser Ser Leu Pro Trp Met Arg Pro Arg Glu His Glu Thr 
                85                  90                  95      


Gln Gln Pro Ser Leu Lys Pro Gln Gln Pro Gly Leu Lys Pro Phe Leu 
            100                 105                 110         


Gln Ser Ala Ala Ala Thr Thr Asn Gln Ala Thr Ala Leu Lys Glu Ala 
        115                 120                 125             


Leu Gln Pro Pro Ile His Leu Gly His Leu Pro Leu Gln Glu Gly Glu 
    130                 135                 140                 


Leu Pro Leu Val Gln Gln Gln Val Ala Pro Ser Asp Lys Pro Pro Lys 
145                 150                 155                 160 


Pro Glu Leu Pro Gly Val Asp Phe Ala Asp Pro Gln Gly Pro Ser Leu 
                165                 170                 175     


Pro Gly Met Asp Phe Pro Asp Pro Gln Gly Pro Ser Leu Pro Gly Leu 
            180                 185                 190         


Asp Phe Ala Asp Pro Gln Gly Ser Thr Ile Phe Gln Ile Ala Arg Leu 
        195                 200                 205             


Ile Ser His Gly Pro Met Pro Gln Asn Lys Gln Ser Pro Leu Tyr Pro 
    210                 215                 220                 


Gly Met Leu Tyr Val Pro Phe Gly Ala Asn Gln Leu Asn Ala Pro Ala 
225                 230                 235                 240 


Arg Leu Gly Ile Met Ser Ser Glu Glu Val Ala Gly Gly Arg Glu Asp 
                245                 250                 255     


Pro Met Ala Tyr Gly Ala Met Phe Pro Gly Phe Gly Gly Met Arg Pro 
            260                 265                 270         


Gly Phe Glu Gly Met Pro His Asn Pro Ala Met Gly Gly Asp Phe Thr 
        275                 280                 285             


Leu Glu Phe Asp Ser Pro Val Ala Ala Thr Lys Gly Pro Glu Asn Glu 
    290                 295                 300                 


Glu Gly Gly Ala Gln Gly Ser Pro Met Pro Glu Ala Asn Pro Asp Asn 
305                 310                 315                 320 


Leu Glu Asn Pro Ala Phe Leu Thr Glu Leu Glu Pro Ala Pro His Ala 
                325                 330                 335     


Gly Leu Leu Ala Leu Pro Lys Asp Asp Ile Pro Gly Leu Pro Arg Ser 
            340                 345                 350         


Pro Ser Gly Lys Met Lys Gly Leu Pro Ser Val Thr Pro Ala Ala Ala 
        355                 360                 365             


Asp Pro Leu Met Thr Pro Glu Leu Ala Asp Val Tyr Arg Thr Tyr Asp 
    370                 375                 380                 


Ala Asp Met Thr Thr Ser Val Asp Phe Gln Glu Glu Ala Thr Met Asp 
385                 390                 395                 400 


Thr Thr Met Ala Pro Asn Ser Leu Gln Thr Ser Met Pro Gly Asn Lys 
                405                 410                 415     


Ala Gln Glu Pro Glu Met Met His Asp Ala Trp His Phe Gln Glu Pro 
            420                 425                 430         


<210>  761
<211>  447
<212>  PRT
<213>  Homo Sapiens

<400>  761

Met Ser Ala Ser Lys Ile Pro Leu Phe Lys Met Lys Asp Leu Ile Leu 
1               5                   10                  15      


Ile Leu Cys Leu Leu Glu Met Ser Phe Ala Val Pro Phe Phe Pro Gln 
            20                  25                  30          


Gln Ser Gly Thr Pro Gly Met Ala Ser Leu Ser Leu Glu Thr Met Arg 
        35                  40                  45              


Gln Leu Gly Ser Leu Gln Arg Leu Asn Thr Leu Ser Gln Tyr Ser Arg 
    50                  55                  60                  


Tyr Gly Phe Gly Lys Ser Phe Asn Ser Leu Trp Met His Gly Leu Leu 
65                  70                  75                  80  


Pro Pro His Ser Ser Leu Pro Trp Met Arg Pro Arg Glu His Glu Thr 
                85                  90                  95      


Gln Gln Tyr Glu Tyr Ser Leu Pro Val His Pro Pro Pro Leu Pro Ser 
            100                 105                 110         


Gln Pro Ser Leu Lys Pro Gln Gln Pro Gly Leu Lys Pro Phe Leu Gln 
        115                 120                 125             


Ser Ala Ala Ala Thr Thr Asn Gln Ala Thr Ala Leu Lys Glu Ala Leu 
    130                 135                 140                 


Gln Pro Pro Ile His Leu Gly His Leu Pro Leu Gln Glu Gly Glu Leu 
145                 150                 155                 160 


Pro Leu Val Gln Gln Gln Val Ala Pro Ser Asp Lys Pro Pro Lys Pro 
                165                 170                 175     


Glu Leu Pro Gly Val Asp Phe Ala Asp Pro Gln Gly Pro Ser Leu Pro 
            180                 185                 190         


Gly Met Asp Phe Pro Asp Pro Gln Gly Pro Ser Leu Pro Gly Leu Asp 
        195                 200                 205             


Phe Ala Asp Pro Gln Gly Ser Thr Ile Phe Gln Ile Ala Arg Leu Ile 
    210                 215                 220                 


Ser His Gly Pro Met Pro Gln Asn Lys Gln Ser Pro Leu Tyr Pro Gly 
225                 230                 235                 240 


Met Leu Tyr Val Pro Phe Gly Ala Asn Gln Leu Asn Ala Pro Ala Arg 
                245                 250                 255     


Leu Gly Ile Met Ser Ser Glu Glu Val Ala Gly Gly Arg Glu Asp Pro 
            260                 265                 270         


Met Ala Tyr Gly Ala Met Phe Pro Gly Phe Gly Gly Met Arg Pro Gly 
        275                 280                 285             


Phe Glu Gly Met Pro His Asn Pro Ala Met Gly Gly Asp Phe Thr Leu 
    290                 295                 300                 


Glu Phe Asp Ser Pro Val Ala Ala Thr Lys Gly Pro Glu Asn Glu Glu 
305                 310                 315                 320 


Gly Gly Ala Gln Gly Ser Pro Met Pro Glu Ala Asn Pro Asp Asn Leu 
                325                 330                 335     


Glu Asn Pro Ala Phe Leu Thr Glu Leu Glu Pro Ala Pro His Ala Gly 
            340                 345                 350         


Leu Leu Ala Leu Pro Lys Asp Asp Ile Pro Gly Leu Pro Arg Ser Pro 
        355                 360                 365             


Ser Gly Lys Met Lys Gly Leu Pro Ser Val Thr Pro Ala Ala Ala Asp 
    370                 375                 380                 


Pro Leu Met Thr Pro Glu Leu Ala Asp Val Tyr Arg Thr Tyr Asp Ala 
385                 390                 395                 400 


Asp Met Thr Thr Ser Val Asp Phe Gln Glu Glu Ala Thr Met Asp Thr 
                405                 410                 415     


Thr Met Ala Pro Asn Ser Leu Gln Thr Ser Met Pro Gly Asn Lys Ala 
            420                 425                 430         


Gln Glu Pro Glu Met Met His Asp Ala Trp His Phe Gln Glu Pro 
        435                 440                 445         


<210>  762
<211>  446
<212>  PRT
<213>  Homo Sapiens

<400>  762

Met Ser Ala Ser Lys Ile Pro Leu Phe Lys Met Lys Asp Leu Ile Leu 
1               5                   10                  15      


Ile Leu Cys Leu Leu Glu Met Ser Phe Ala Val Pro Phe Phe Pro Gln 
            20                  25                  30          


Gln Ser Gly Thr Pro Gly Met Ala Ser Leu Ser Leu Glu Thr Met Arg 
        35                  40                  45              


Gln Leu Gly Ser Leu Gln Arg Leu Asn Thr Leu Ser Gln Tyr Ser Arg 
    50                  55                  60                  


Tyr Gly Phe Gly Lys Ser Phe Asn Ser Leu Trp Met His Gly Leu Leu 
65                  70                  75                  80  


Pro Pro His Ser Ser Leu Pro Trp Met Arg Pro Arg Glu His Glu Thr 
                85                  90                  95      


Gln Gln Tyr Glu Tyr Ser Leu Pro Val His Pro Pro Pro Leu Pro Ser 
            100                 105                 110         


Gln Pro Ser Leu Lys Pro Gln Gln Pro Gly Leu Lys Pro Phe Leu Gln 
        115                 120                 125             


Ser Ala Ala Ala Thr Thr Asn Gln Ala Thr Ala Leu Lys Glu Ala Leu 
    130                 135                 140                 


Gln Pro Pro Ile His Leu Gly His Leu Pro Leu Gln Glu Gly Glu Leu 
145                 150                 155                 160 


Pro Leu Val Gln Gln Gln Val Ala Pro Ser Asp Lys Pro Pro Lys Pro 
                165                 170                 175     


Glu Leu Arg Val Asp Phe Ala Asp Pro Gln Gly Pro Ser Leu Pro Gly 
            180                 185                 190         


Met Asp Phe Pro Asp Pro Gln Gly Pro Ser Leu Pro Gly Leu Asp Phe 
        195                 200                 205             


Ala Asp Pro Gln Gly Ser Thr Ile Phe Gln Ile Ala Arg Leu Ile Ser 
    210                 215                 220                 


His Gly Pro Met Pro Gln Asn Lys Gln Ser Pro Leu Tyr Pro Gly Met 
225                 230                 235                 240 


Leu Tyr Val Pro Phe Gly Ala Asn Gln Leu Asn Ala Pro Ala Arg Leu 
                245                 250                 255     


Gly Ile Met Ser Ser Glu Glu Val Ala Gly Gly Arg Glu Asp Pro Met 
            260                 265                 270         


Ala Tyr Gly Ala Met Phe Pro Gly Phe Gly Gly Met Arg Pro Gly Phe 
        275                 280                 285             


Glu Gly Met Pro His Asn Pro Ala Met Gly Gly Asp Phe Thr Leu Glu 
    290                 295                 300                 


Phe Asp Ser Pro Val Ala Ala Thr Lys Gly Pro Glu Asn Glu Glu Gly 
305                 310                 315                 320 


Gly Ala Gln Gly Ser Pro Met Pro Glu Ala Asn Pro Asp Asn Leu Glu 
                325                 330                 335     


Asn Pro Ala Phe Leu Thr Glu Leu Glu Pro Ala Pro His Ala Gly Leu 
            340                 345                 350         


Leu Ala Leu Pro Lys Asp Asp Ile Pro Gly Leu Pro Arg Ser Pro Ser 
        355                 360                 365             


Gly Lys Met Lys Gly Leu Pro Ser Val Thr Pro Ala Ala Ala Asp Pro 
    370                 375                 380                 


Leu Met Thr Pro Glu Leu Ala Asp Val Tyr Arg Thr Tyr Asp Ala Asp 
385                 390                 395                 400 


Met Thr Thr Ser Val Asp Phe Gln Glu Glu Ala Thr Met Asp Thr Thr 
                405                 410                 415     


Met Ala Pro Asn Ser Leu Gln Thr Ser Met Pro Gly Asn Lys Ala Gln 
            420                 425                 430         


Glu Pro Glu Met Met His Asp Ala Trp His Phe Gln Glu Pro 
        435                 440                 445     


<210>  763
<211>  193
<212>  PRT
<213>  Homo Sapiens

<400>  763

His Lys Ser Lys Trp Asn Ile Thr Met Glu Ser Tyr Val Val His Thr 
1               5                   10                  15      


Asn Tyr Asp Glu Tyr Ala Ile Phe Leu Thr Lys Lys Phe Ser Arg His 
            20                  25                  30          


His Gly Pro Thr Ile Thr Ala Lys Leu Tyr Gly Arg Ala Pro Gln Leu 
        35                  40                  45              


Arg Glu Thr Leu Leu Gln Asp Phe Arg Val Val Ala Gln Gly Val Gly 
    50                  55                  60                  


Ile Pro Glu Asp Ser Ile Phe Thr Met Ala Asp Arg Gly Glu Cys Val 
65                  70                  75                  80  


Pro Gly Glu Gln Glu Pro Glu Pro Ile Leu Ile Pro Arg Val Arg Arg 
                85                  90                  95      


Ala Val Leu Pro Gln Glu Glu Glu Gly Ser Gly Gly Gly Gln Leu Val 
            100                 105                 110         


Thr Glu Val Thr Lys Lys Glu Asp Ser Cys Gln Leu Gly Tyr Ser Ala 
        115                 120                 125             


Gly Pro Cys Met Gly Met Thr Ser Arg Tyr Phe Tyr Asn Gly Thr Ser 
    130                 135                 140                 


Met Ala Cys Glu Thr Phe Gln Tyr Gly Gly Cys Met Gly Asn Gly Asn 
145                 150                 155                 160 


Asn Phe Val Thr Val Arg Gly Pro Cys Arg Ala Phe Ile Gln Leu Trp 
                165                 170                 175     


Ala Phe Asp Ala Val Lys Gly Lys Cys Val Leu Phe Pro Tyr Gly Gly 
            180                 185                 190         


Cys 
    


<210>  764
<211>  352
<212>  PRT
<213>  Homo Sapiens

<400>  764

Met Arg Ser Leu Gly Ala Leu Leu Leu Leu Leu Ser Ala Cys Leu Ala 
1               5                   10                  15      


Val Ser Ala Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln 
            20                  25                  30          


Glu Asn Phe Asn Ile Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala 
        35                  40                  45              


Ile Gly Ser Thr Cys Pro Trp Leu Lys Lys Ile Met Asp Arg Met Thr 
    50                  55                  60                  


Val Ser Thr Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser 
65                  70                  75                  80  


Met Thr Ser Thr Arg Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly 
                85                  90                  95      


Ala Tyr Glu Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser 
            100                 105                 110         


Lys Trp Asn Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp 
        115                 120                 125             


Glu Tyr Ala Ile Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro 
    130                 135                 140                 


Thr Ile Thr Ala Lys Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr 
145                 150                 155                 160 


Leu Leu Gln Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu 
                165                 170                 175     


Asp Ser Ile Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu 
            180                 185                 190         


Gln Glu Pro Glu Pro Ile Leu Ile Pro Arg Val Arg Arg Ala Val Leu 
        195                 200                 205             


Pro Gln Glu Glu Glu Gly Ser Gly Gly Gly Gln Leu Val Thr Glu Val 
    210                 215                 220                 


Thr Lys Lys Glu Asp Ser Cys Gln Leu Gly Tyr Ser Ala Gly Pro Cys 
225                 230                 235                 240 


Met Gly Met Thr Ser Arg Tyr Phe Tyr Asn Gly Thr Ser Met Ala Cys 
                245                 250                 255     


Glu Thr Phe Gln Tyr Gly Gly Cys Met Gly Asn Gly Asn Asn Phe Val 
            260                 265                 270         


Thr Glu Lys Glu Cys Leu Gln Thr Cys Arg Thr Val Ala Ala Cys Asn 
        275                 280                 285             


Leu Pro Ile Val Arg Gly Pro Cys Arg Ala Phe Ile Gln Leu Trp Ala 
    290                 295                 300                 


Phe Asp Ala Val Lys Gly Lys Cys Val Leu Phe Pro Tyr Gly Gly Cys 
305                 310                 315                 320 


Gln Gly Asn Gly Asn Lys Phe Tyr Ser Glu Lys Glu Cys Arg Glu Tyr 
                325                 330                 335     


Cys Gly Val Pro Gly Asp Gly Asp Glu Glu Leu Leu Arg Phe Ser Asn 
            340                 345                 350         


<210>  765
<211>  238
<212>  PRT
<213>  Homo Sapiens

<400>  765

Met Arg Ser Leu Gly Ala Leu Leu Leu Leu Leu Ser Ala Cys Leu Ala 
1               5                   10                  15      


Val Ser Ala Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln 
            20                  25                  30          


Glu Asn Phe Asn Ile Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala 
        35                  40                  45              


Ile Gly Ser Thr Cys Pro Trp Leu Lys Lys Ile Met Asp Arg Met Thr 
    50                  55                  60                  


Val Ser Thr Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser 
65                  70                  75                  80  


Met Thr Ser Thr Arg Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly 
                85                  90                  95      


Ala Tyr Glu Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser 
            100                 105                 110         


Lys Trp Asn Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp 
        115                 120                 125             


Glu Tyr Ala Ile Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro 
    130                 135                 140                 


Thr Ile Thr Ala Lys Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr 
145                 150                 155                 160 


Leu Leu Gln Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu 
                165                 170                 175     


Asp Ser Ile Phe Thr Met Ala Asp Arg Val Asn Gly Leu Glu Gln Ala 
            180                 185                 190         


Thr Gln Ala Gly Pro Phe Met Lys Trp Thr Lys Ala Arg Gln Val Pro 
        195                 200                 205             


Ser Thr Met Leu Thr Lys Asp Thr Asn Pro Gly Leu Gly Trp Pro Leu 
    210                 215                 220                 


Gly Leu Val Leu Leu Phe Thr Pro Leu Ser Cys Ser Val Thr 
225                 230                 235             


<210>  766
<211>  205
<212>  PRT
<213>  Homo Sapiens

<400>  766

Met Gly Thr Trp Ile Leu Phe Ala Cys Leu Leu Gly Ala Ala Phe Ala 
1               5                   10                  15      


Met Pro Leu Pro Pro His Pro Gly His Pro Gly Tyr Ile Asn Phe Ser 
            20                  25                  30          


Tyr Glu Asn Ser His Ser Gln Ala Ile Asn Val Asp Arg Thr Ala Leu 
        35                  40                  45              


Val Leu Thr Pro Leu Lys Trp Tyr Gln Ser Ile Arg Pro Pro Tyr Pro 
    50                  55                  60                  


Ser Tyr Gly Tyr Glu Pro Met Gly Gly Trp Leu His His Gln Ile Ile 
65                  70                  75                  80  


Pro Val Leu Ser Gln Gln His Pro Pro Thr His Thr Leu Gln Pro His 
                85                  90                  95      


His His Ile Pro Val Val Pro Ala Gln Gln Pro Val Ile Pro Gln Gln 
            100                 105                 110         


Pro Met Met Pro Val Pro Gly Gln His Ser Met Thr Pro Ile Gln His 
        115                 120                 125             


His Gln Pro Asn Leu Pro Pro Pro Ala Gln Gln Pro Tyr Gln Pro Gln 
    130                 135                 140                 


Pro Val Gln Pro Gln Pro His Gln Pro Met Gln Pro Gln Pro Pro Val 
145                 150                 155                 160 


His Pro Met Gln Pro Leu Pro Pro Gln Pro Pro Leu Pro Pro Met Phe 
                165                 170                 175     


Pro Met Gln Pro Leu Pro Pro Met Leu Pro Asp Leu Thr Leu Glu Ala 
            180                 185                 190         


Trp Pro Ser Thr Asp Lys Thr Lys Arg Glu Glu Val Asp 
        195                 200                 205 


<210>  767
<211>  191
<212>  PRT
<213>  Homo Sapiens

<400>  767

Met Gly Thr Trp Ile Leu Phe Ala Cys Leu Leu Gly Ala Ala Phe Ala 
1               5                   10                  15      


Met Pro Leu Pro Pro His Pro Gly His Pro Gly Tyr Ile Asn Phe Ser 
            20                  25                  30          


Tyr Glu Val Leu Thr Pro Leu Lys Trp Tyr Gln Ser Ile Arg Pro Pro 
        35                  40                  45              


Tyr Pro Ser Tyr Gly Tyr Glu Pro Met Gly Gly Trp Leu His His Gln 
    50                  55                  60                  


Ile Ile Pro Val Leu Ser Gln Gln His Pro Pro Thr His Thr Leu Gln 
65                  70                  75                  80  


Pro His His His Ile Pro Val Val Pro Ala Gln Gln Pro Val Ile Pro 
                85                  90                  95      


Gln Gln Pro Met Met Pro Val Pro Gly Gln His Ser Met Thr Pro Ile 
            100                 105                 110         


Gln His His Gln Pro Asn Leu Pro Pro Pro Ala Gln Gln Pro Tyr Gln 
        115                 120                 125             


Pro Gln Pro Val Gln Pro Gln Pro His Gln Pro Met Gln Pro Gln Pro 
    130                 135                 140                 


Pro Val His Pro Met Gln Pro Leu Pro Pro Gln Pro Pro Leu Pro Pro 
145                 150                 155                 160 


Met Phe Pro Met Gln Pro Leu Pro Pro Met Leu Pro Asp Leu Thr Leu 
                165                 170                 175     


Glu Ala Trp Pro Ser Thr Asp Lys Thr Lys Arg Glu Glu Val Asp 
            180                 185                 190     


<210>  768
<211>  175
<212>  PRT
<213>  Homo Sapiens

<400>  768

Met Gly Thr Trp Ile Leu Phe Ala Cys Leu Leu Gly Ala Ala Phe Ala 
1               5                   10                  15      


Met Pro Val Leu Thr Pro Leu Lys Trp Tyr Gln Ser Ile Arg Pro Pro 
            20                  25                  30          


Tyr Pro Ser Tyr Gly Tyr Glu Pro Met Gly Gly Trp Leu His His Gln 
        35                  40                  45              


Ile Ile Pro Val Leu Ser Gln Gln His Pro Pro Thr His Thr Leu Gln 
    50                  55                  60                  


Pro His His His Ile Pro Val Val Pro Ala Gln Gln Pro Val Ile Pro 
65                  70                  75                  80  


Gln Gln Pro Met Met Pro Val Pro Gly Gln His Ser Met Thr Pro Ile 
                85                  90                  95      


Gln His His Gln Pro Asn Leu Pro Pro Pro Ala Gln Gln Pro Tyr Gln 
            100                 105                 110         


Pro Gln Pro Val Gln Pro Gln Pro His Gln Pro Met Gln Pro Gln Pro 
        115                 120                 125             


Pro Val His Pro Met Gln Pro Leu Pro Pro Gln Pro Pro Leu Pro Pro 
    130                 135                 140                 


Met Phe Pro Met Gln Pro Leu Pro Pro Met Leu Pro Asp Leu Thr Leu 
145                 150                 155                 160 


Glu Ala Trp Pro Ser Thr Asp Lys Thr Lys Arg Glu Glu Val Asp 
                165                 170                 175 


<210>  769
<211>  206
<212>  PRT
<213>  Homo Sapiens

<400>  769

Met Gly Thr Trp Ile Leu Phe Ala Cys Leu Val Gly Ala Ala Phe Ala 
1               5                   10                  15      


Met Pro Leu Pro Pro His Pro Gly His Pro Gly Tyr Ile Asn Phe Ser 
            20                  25                  30          


Tyr Glu Asn Ser His Ser Gln Ala Ile Asn Val Asp Arg Ile Ala Leu 
        35                  40                  45              


Val Leu Thr Pro Leu Lys Trp Tyr Gln Ser Met Ile Arg Pro Pro Tyr 
    50                  55                  60                  


Ser Ser Tyr Gly Tyr Glu Pro Met Gly Gly Trp Leu His His Gln Ile 
65                  70                  75                  80  


Ile Pro Val Val Ser Gln Gln His Pro Leu Thr His Thr Leu Gln Ser 
                85                  90                  95      


His His His Ile Pro Val Val Pro Ala Gln Gln Pro Arg Val Arg Gln 
            100                 105                 110         


Gln Ala Leu Met Pro Val Pro Gly Gln Gln Ser Met Thr Pro Thr Gln 
        115                 120                 125             


His His Gln Pro Asn Leu Pro Leu Pro Ala Gln Gln Pro Phe Gln Pro 
    130                 135                 140                 


Gln Pro Val Gln Pro Gln Pro His Gln Pro Met Gln Pro Gln Pro Pro 
145                 150                 155                 160 


Val Gln Pro Met Gln Pro Leu Leu Pro Gln Pro Pro Leu Pro Pro Met 
                165                 170                 175     


Phe Pro Leu Arg Pro Leu Pro Pro Ile Leu Pro Asp Leu His Leu Glu 
            180                 185                 190         


Ala Trp Pro Ala Thr Asp Lys Thr Lys Gln Glu Glu Val Asp 
        195                 200                 205     


<210>  770
<211>  192
<212>  PRT
<213>  Homo Sapiens

<400>  770

Met Gly Thr Trp Ile Leu Phe Ala Cys Leu Val Gly Ala Ala Phe Ala 
1               5                   10                  15      


Met Pro Leu Pro Pro His Pro Gly His Pro Gly Tyr Ile Asn Phe Ser 
            20                  25                  30          


Tyr Glu Val Leu Thr Pro Leu Lys Trp Tyr Gln Ser Met Ile Arg Pro 
        35                  40                  45              


Pro Tyr Ser Ser Tyr Gly Tyr Glu Pro Met Gly Gly Trp Leu His His 
    50                  55                  60                  


Gln Ile Ile Pro Val Val Ser Gln Gln His Pro Leu Thr His Thr Leu 
65                  70                  75                  80  


Gln Ser His His His Ile Pro Val Val Pro Ala Gln Gln Pro Arg Val 
                85                  90                  95      


Arg Gln Gln Ala Leu Met Pro Val Pro Gly Gln Gln Ser Met Thr Pro 
            100                 105                 110         


Thr Gln His His Gln Pro Asn Leu Pro Leu Pro Ala Gln Gln Pro Phe 
        115                 120                 125             


Gln Pro Gln Pro Val Gln Pro Gln Pro His Gln Pro Met Gln Pro Gln 
    130                 135                 140                 


Pro Pro Val Gln Pro Met Gln Pro Leu Leu Pro Gln Pro Pro Leu Pro 
145                 150                 155                 160 


Pro Met Phe Pro Leu Arg Pro Leu Pro Pro Ile Leu Pro Asp Leu His 
                165                 170                 175     


Leu Glu Ala Trp Pro Ala Thr Asp Lys Thr Lys Gln Glu Glu Val Asp 
            180                 185                 190         


<210>  771
<211>  560
<212>  PRT
<213>  Homo Sapiens

<400>  771

Met Arg Asp Leu Pro Leu Thr Ser Leu Ala Leu Val Leu Ser Ala Leu 
1               5                   10                  15      


Gly Ala Leu Leu Gly Thr Glu Ala Leu Arg Ala Glu Glu Pro Ala Val 
            20                  25                  30          


Gly Thr Ser Gly Leu Ile Phe Arg Glu Asp Leu Asp Trp Pro Pro Gly 
        35                  40                  45              


Ser Pro Gln Glu Pro Leu Cys Leu Val Ala Leu Gly Gly Asp Ser Asn 
    50                  55                  60                  


Gly Ser Ser Ser Pro Leu Arg Val Val Gly Ala Leu Ser Ala Tyr Glu 
65                  70                  75                  80  


Gln Ala Phe Leu Gly Ala Val Gln Arg Ala Arg Trp Gly Pro Arg Asp 
                85                  90                  95      


Leu Ala Thr Phe Gly Val Cys Asn Thr Gly Asp Arg Gln Ala Ala Leu 
            100                 105                 110         


Pro Ser Leu Arg Arg Leu Gly Ala Trp Leu Arg Asp Pro Gly Gly Gln 
        115                 120                 125             


Arg Leu Val Val Leu His Leu Glu Glu Val Thr Trp Glu Pro Thr Pro 
    130                 135                 140                 


Ser Leu Arg Phe Gln Glu Pro Pro Pro Gly Gly Ala Gly Pro Pro Glu 
145                 150                 155                 160 


Leu Ala Leu Leu Val Leu Tyr Pro Gly Pro Gly Pro Glu Val Thr Val 
                165                 170                 175     


Thr Arg Ala Gly Leu Pro Gly Ala Gln Ser Leu Cys Pro Ser Arg Asp 
            180                 185                 190         


Thr Arg Tyr Leu Val Leu Ala Val Asp Arg Pro Ala Gly Ala Trp Arg 
        195                 200                 205             


Gly Ser Gly Leu Ala Leu Thr Leu Gln Pro Arg Gly Glu Asp Ser Arg 
    210                 215                 220                 


Leu Ser Thr Ala Arg Leu Gln Ala Leu Leu Phe Gly Asp Asp His Arg 
225                 230                 235                 240 


Cys Phe Thr Arg Met Thr Pro Ala Leu Leu Leu Leu Pro Arg Ser Glu 
                245                 250                 255     


Pro Ala Pro Leu Pro Ala His Gly Gln Leu Asp Thr Val Pro Phe Pro 
            260                 265                 270         


Pro Pro Arg Pro Ser Ala Glu Leu Glu Glu Ser Pro Pro Ser Ala Asp 
        275                 280                 285             


Pro Phe Leu Glu Thr Leu Thr Arg Leu Val Arg Ala Leu Arg Val Pro 
    290                 295                 300                 


Pro Ala Arg Ala Ser Ala Pro Arg Leu Ala Leu Asp Pro Asp Ala Leu 
305                 310                 315                 320 


Ala Gly Phe Pro Gln Gly Leu Val Asn Leu Ser Asp Pro Ala Ala Leu 
                325                 330                 335     


Glu Arg Leu Leu Asp Gly Glu Glu Pro Leu Leu Leu Leu Leu Arg Pro 
            340                 345                 350         


Thr Ala Ala Thr Thr Gly Asp Pro Ala Pro Leu His Asp Pro Thr Ser 
        355                 360                 365             


Ala Pro Trp Ala Thr Ala Leu Ala Arg Arg Val Ala Ala Glu Leu Gln 
    370                 375                 380                 


Ala Ala Ala Ala Glu Leu Arg Ser Leu Pro Gly Leu Pro Pro Ala Thr 
385                 390                 395                 400 


Ala Pro Leu Leu Ala Arg Leu Leu Ala Leu Cys Pro Gly Gly Pro Gly 
                405                 410                 415     


Gly Leu Gly Asp Pro Leu Arg Ala Leu Leu Leu Leu Lys Ala Leu Gln 
            420                 425                 430         


Gly Leu Arg Val Glu Trp Arg Gly Arg Asp Pro Arg Gly Pro Gly Arg 
        435                 440                 445             


Ala Gln Arg Ser Ala Gly Ala Thr Ala Ala Asp Gly Pro Cys Ala Leu 
    450                 455                 460                 


Arg Glu Leu Ser Val Asp Leu Arg Ala Glu Arg Ser Val Leu Ile Pro 
465                 470                 475                 480 


Glu Thr Tyr Gln Ala Asn Asn Cys Gln Gly Val Cys Gly Trp Pro Gln 
                485                 490                 495     


Ser Asp Arg Asn Pro Arg Tyr Gly Asn His Val Val Leu Leu Leu Lys 
            500                 505                 510         


Met Gln Val Arg Gly Ala Ala Leu Ala Arg Pro Pro Cys Cys Val Pro 
        515                 520                 525             


Thr Ala Tyr Ala Gly Lys Leu Leu Ile Ser Leu Ser Glu Glu Arg Ile 
    530                 535                 540                 


Ser Ala His His Val Pro Asn Met Val Ala Thr Glu Cys Gly Cys Arg 
545                 550                 555                 560 


<210>  772
<211>  780
<212>  PRT
<213>  Homo Sapiens

<400>  772

Met Asn Val Arg Ile Phe Tyr Ser Val Ser Gln Ser Pro His Ser Leu 
1               5                   10                  15      


Leu Ser Leu Leu Phe Tyr Cys Ala Ile Leu Glu Ser Arg Ile Ser Ala 
            20                  25                  30          


Thr Met Pro Leu Phe Lys Leu Pro Ala Glu Glu Lys Gln Ile Asp Asp 
        35                  40                  45              


Ala Met Arg Asn Phe Ala Glu Lys Val Phe Ala Ser Glu Val Lys Asp 
    50                  55                  60                  


Glu Gly Gly Arg Gln Glu Ile Ser Pro Phe Asp Val Asp Glu Ile Cys 
65                  70                  75                  80  


Pro Ile Ser His His Glu Met Gln Ala His Ile Phe His Leu Glu Thr 
                85                  90                  95      


Leu Ser Thr Ser Thr Glu Ala Arg Arg Lys Lys Arg Phe Gln Gly Arg 
            100                 105                 110         


Lys Thr Val Asn Leu Ser Ile Pro Leu Ser Glu Thr Ser Ser Thr Lys 
        115                 120                 125             


Leu Ser His Ile Asp Glu Tyr Ile Ser Ser Ser Pro Thr Tyr Gln Thr 
    130                 135                 140                 


Val Pro Asp Phe Gln Arg Val Gln Ile Thr Gly Asp Tyr Ala Ser Gly 
145                 150                 155                 160 


Val Thr Val Glu Asp Phe Glu Ile Val Cys Lys Gly Leu Tyr Arg Ala 
                165                 170                 175     


Leu Cys Ile Arg Glu Lys Tyr Met Gln Lys Ser Phe Gln Arg Phe Pro 
            180                 185                 190         


Lys Thr Pro Ser Lys Tyr Leu Arg Asn Ile Asp Gly Glu Ala Trp Val 
        195                 200                 205             


Ala Asn Glu Ser Phe Tyr Pro Val Phe Thr Pro Pro Val Lys Lys Gly 
    210                 215                 220                 


Glu Asp Pro Phe Arg Thr Asp Asn Leu Pro Glu Asn Leu Gly Tyr His 
225                 230                 235                 240 


Leu Lys Met Lys Asp Gly Val Val Tyr Val Tyr Pro Asn Glu Ala Ala 
                245                 250                 255     


Val Ser Lys Asp Glu Pro Lys Pro Leu Pro Tyr Pro Asn Leu Asp Thr 
            260                 265                 270         


Phe Leu Asp Asp Met Asn Phe Leu Leu Ala Leu Ile Ala Gln Gly Pro 
        275                 280                 285             


Val Lys Thr Tyr Thr His Arg Arg Leu Lys Phe Leu Ser Ser Lys Phe 
    290                 295                 300                 


Gln Val His Gln Met Leu Asn Glu Met Asp Glu Leu Lys Glu Leu Lys 
305                 310                 315                 320 


Asn Asn Pro His Arg Asp Phe Tyr Asn Cys Arg Lys Val Asp Thr His 
                325                 330                 335     


Ile His Ala Ala Ala Cys Met Asn Gln Lys His Leu Leu Arg Phe Ile 
            340                 345                 350         


Lys Lys Ser Tyr Gln Ile Asp Ala Asp Arg Val Val Tyr Ser Thr Lys 
        355                 360                 365             


Glu Lys Asn Leu Thr Leu Lys Glu Leu Phe Ala Lys Leu Lys Met His 
    370                 375                 380                 


Pro Tyr Asp Leu Thr Val Asp Ser Leu Asp Val His Ala Gly Arg Gln 
385                 390                 395                 400 


Thr Phe Gln Arg Phe Asp Lys Phe Asn Asp Lys Tyr Asn Pro Val Gly 
                405                 410                 415     


Ala Ser Glu Leu Arg Asp Leu Tyr Leu Lys Thr Asp Asn Tyr Ile Asn 
            420                 425                 430         


Gly Glu Tyr Phe Ala Thr Ile Ile Lys Glu Val Gly Ala Asp Leu Val 
        435                 440                 445             


Glu Ala Lys Tyr Gln His Ala Glu Pro Arg Leu Ser Ile Tyr Gly Arg 
    450                 455                 460                 


Ser Pro Asp Glu Trp Ser Lys Leu Ser Ser Trp Phe Val Cys Asn Arg 
465                 470                 475                 480 


Ile His Cys Pro Asn Met Thr Trp Met Ile Gln Val Pro Arg Ile Tyr 
                485                 490                 495     


Asp Val Phe Arg Ser Lys Asn Phe Leu Pro His Phe Gly Lys Met Leu 
            500                 505                 510         


Glu Asn Ile Phe Met Pro Val Phe Glu Ala Thr Ile Asn Pro Gln Ala 
        515                 520                 525             


Asp Pro Glu Leu Ser Val Phe Leu Lys His Ile Thr Gly Phe Asp Ser 
    530                 535                 540                 


Val Asp Asp Glu Ser Lys His Ser Gly His Met Phe Ser Ser Lys Ser 
545                 550                 555                 560 


Pro Lys Pro Gln Glu Trp Thr Leu Glu Lys Asn Pro Ser Tyr Thr Tyr 
                565                 570                 575     


Tyr Ala Tyr Tyr Met Tyr Ala Asn Ile Met Val Leu Asn Ser Leu Arg 
            580                 585                 590         


Lys Glu Arg Gly Met Asn Thr Phe Leu Phe Arg Pro His Cys Gly Glu 
        595                 600                 605             


Ala Gly Ala Leu Thr His Leu Met Thr Ala Phe Met Ile Ala Asp Asp 
    610                 615                 620                 


Ile Ser His Gly Leu Asn Leu Lys Lys Ser Pro Val Leu Gln Tyr Leu 
625                 630                 635                 640 


Phe Phe Leu Ala Gln Ile Pro Ile Ala Met Ser Pro Leu Ser Asn Asn 
                645                 650                 655     


Ser Leu Phe Leu Glu Tyr Ala Lys Asn Pro Phe Leu Asp Phe Leu Gln 
            660                 665                 670         


Lys Gly Leu Met Ile Ser Leu Ser Thr Asp Asp Pro Met Gln Phe His 
        675                 680                 685             


Phe Thr Lys Glu Pro Leu Met Glu Glu Tyr Ala Ile Ala Ala Gln Val 
    690                 695                 700                 


Phe Lys Leu Ser Thr Cys Asp Met Cys Glu Val Ala Arg Asn Ser Val 
705                 710                 715                 720 


Leu Gln Cys Gly Ile Ser His Glu Glu Lys Val Lys Phe Leu Gly Asp 
                725                 730                 735     


Asn Tyr Leu Glu Glu Gly Pro Ala Gly Asn Asp Ile Arg Arg Thr Asn 
            740                 745                 750         


Val Ala Gln Ile Arg Met Ala Tyr Arg Tyr Glu Thr Trp Cys Tyr Glu 
        755                 760                 765             


Leu Asn Leu Ile Ala Glu Gly Leu Lys Ser Thr Glu 
    770                 775                 780 


<210>  773
<211>  776
<212>  PRT
<213>  Homo Sapiens

<400>  773

Met Asn Val Arg Ile Phe Tyr Ser Val Ser Gln Ser Pro His Ser Leu 
1               5                   10                  15      


Leu Ser Leu Leu Phe Tyr Cys Ala Ile Leu Glu Ser Arg Ile Ser Ala 
            20                  25                  30          


Thr Met Pro Leu Phe Lys Leu Pro Glu Ile Asp Asp Ala Met Arg Asn 
        35                  40                  45              


Phe Ala Glu Lys Val Phe Ala Ser Glu Val Lys Asp Glu Gly Gly Arg 
    50                  55                  60                  


Gln Glu Ile Ser Pro Phe Asp Val Asp Glu Ile Cys Pro Ile Ser His 
65                  70                  75                  80  


His Glu Met Gln Ala His Ile Phe His Leu Glu Thr Leu Ser Thr Ser 
                85                  90                  95      


Thr Glu Ala Arg Arg Lys Lys Arg Phe Gln Gly Arg Lys Thr Val Asn 
            100                 105                 110         


Leu Ser Ile Pro Leu Ser Glu Thr Ser Ser Thr Lys Leu Ser His Ile 
        115                 120                 125             


Asp Glu Tyr Ile Ser Ser Ser Pro Thr Tyr Gln Thr Val Pro Asp Phe 
    130                 135                 140                 


Gln Arg Val Gln Ile Thr Gly Asp Tyr Ala Ser Gly Val Thr Val Glu 
145                 150                 155                 160 


Asp Phe Glu Ile Val Cys Lys Gly Leu Tyr Arg Ala Leu Cys Ile Arg 
                165                 170                 175     


Glu Lys Tyr Met Gln Lys Ser Phe Gln Arg Phe Pro Lys Thr Pro Ser 
            180                 185                 190         


Lys Tyr Leu Arg Asn Ile Asp Gly Glu Ala Trp Val Ala Asn Glu Ser 
        195                 200                 205             


Phe Tyr Pro Val Phe Thr Pro Pro Val Lys Lys Gly Glu Asp Pro Phe 
    210                 215                 220                 


Arg Thr Asp Asn Leu Pro Glu Asn Leu Gly Tyr His Leu Lys Met Lys 
225                 230                 235                 240 


Asp Gly Val Val Tyr Val Tyr Pro Asn Glu Ala Ala Val Ser Lys Asp 
                245                 250                 255     


Glu Pro Lys Pro Leu Pro Tyr Pro Asn Leu Asp Thr Phe Leu Asp Asp 
            260                 265                 270         


Met Asn Phe Leu Leu Ala Leu Ile Ala Gln Gly Pro Val Lys Thr Tyr 
        275                 280                 285             


Thr His Arg Arg Leu Lys Phe Leu Ser Ser Lys Phe Gln Val His Gln 
    290                 295                 300                 


Met Leu Asn Glu Met Asp Glu Leu Lys Glu Leu Lys Asn Asn Pro His 
305                 310                 315                 320 


Arg Asp Phe Tyr Asn Cys Arg Lys Val Asp Thr His Ile His Ala Ala 
                325                 330                 335     


Ala Cys Met Asn Gln Lys His Leu Leu Arg Phe Ile Lys Lys Ser Tyr 
            340                 345                 350         


Gln Ile Asp Ala Asp Arg Val Val Tyr Ser Thr Lys Glu Lys Asn Leu 
        355                 360                 365             


Thr Leu Lys Glu Leu Phe Ala Lys Leu Lys Met His Pro Tyr Asp Leu 
    370                 375                 380                 


Thr Val Asp Ser Leu Asp Val His Ala Gly Arg Gln Thr Phe Gln Arg 
385                 390                 395                 400 


Phe Asp Lys Phe Asn Asp Lys Tyr Asn Pro Val Gly Ala Ser Glu Leu 
                405                 410                 415     


Arg Asp Leu Tyr Leu Lys Thr Asp Asn Tyr Ile Asn Gly Glu Tyr Phe 
            420                 425                 430         


Ala Thr Ile Ile Lys Glu Val Gly Ala Asp Leu Val Glu Ala Lys Tyr 
        435                 440                 445             


Gln His Ala Glu Pro Arg Leu Ser Ile Tyr Gly Arg Ser Pro Asp Glu 
    450                 455                 460                 


Trp Ser Lys Leu Ser Ser Trp Phe Val Cys Asn Arg Ile His Cys Pro 
465                 470                 475                 480 


Asn Met Thr Trp Met Ile Gln Val Pro Arg Ile Tyr Asp Val Phe Arg 
                485                 490                 495     


Ser Lys Asn Phe Leu Pro His Phe Gly Lys Met Leu Glu Asn Ile Phe 
            500                 505                 510         


Met Pro Val Phe Glu Ala Thr Ile Asn Pro Gln Ala Asp Pro Glu Leu 
        515                 520                 525             


Ser Val Phe Leu Lys His Ile Thr Gly Phe Asp Ser Val Asp Asp Glu 
    530                 535                 540                 


Ser Lys His Ser Gly His Met Phe Ser Ser Lys Ser Pro Lys Pro Gln 
545                 550                 555                 560 


Glu Trp Thr Leu Glu Lys Asn Pro Ser Tyr Thr Tyr Tyr Ala Tyr Tyr 
                565                 570                 575     


Met Tyr Ala Asn Ile Met Val Leu Asn Ser Leu Arg Lys Glu Arg Gly 
            580                 585                 590         


Met Asn Thr Phe Leu Phe Arg Pro His Cys Gly Glu Ala Gly Ala Leu 
        595                 600                 605             


Thr His Leu Met Thr Ala Phe Met Ile Ala Asp Asp Ile Ser His Gly 
    610                 615                 620                 


Leu Asn Leu Lys Lys Ser Pro Val Leu Gln Tyr Leu Phe Phe Leu Ala 
625                 630                 635                 640 


Gln Ile Pro Ile Ala Met Ser Pro Leu Ser Asn Asn Ser Leu Phe Leu 
                645                 650                 655     


Glu Tyr Ala Lys Asn Pro Phe Leu Asp Phe Leu Gln Lys Gly Leu Met 
            660                 665                 670         


Ile Ser Leu Ser Thr Asp Asp Pro Met Gln Phe His Phe Thr Lys Glu 
        675                 680                 685             


Pro Leu Met Glu Glu Tyr Ala Ile Ala Ala Gln Val Phe Lys Leu Ser 
    690                 695                 700                 


Thr Cys Asp Met Cys Glu Val Ala Arg Asn Ser Val Leu Gln Cys Gly 
705                 710                 715                 720 


Ile Ser His Glu Glu Lys Val Lys Phe Leu Gly Asp Asn Tyr Leu Glu 
                725                 730                 735     


Glu Gly Pro Ala Gly Asn Asp Ile Arg Arg Thr Asn Val Ala Gln Ile 
            740                 745                 750         


Arg Met Ala Tyr Arg Tyr Glu Thr Trp Cys Tyr Glu Leu Asn Leu Ile 
        755                 760                 765             


Ala Glu Gly Leu Lys Ser Thr Glu 
    770                 775     


<210>  774
<211>  191
<212>  PRT
<213>  Homo Sapiens

<400>  774

Gln Cys Leu Cys Ser Asn Ser Gln Val Gly Val Gln Lys Ile Asp Asp 
1               5                   10                  15      


Ala Met Arg Asn Phe Ala Glu Lys Val Phe Ala Ser Glu Val Lys Asp 
            20                  25                  30          


Glu Gly Gly Arg Gln Glu Ile Ser Pro Phe Asp Val Asp Glu Ile Cys 
        35                  40                  45              


Pro Ile Ser His His Glu Met Gln Ala His Ile Phe His Leu Glu Thr 
    50                  55                  60                  


Leu Ser Thr Ser Thr Glu Ala Arg Arg Lys Lys Arg Phe Gln Gly Arg 
65                  70                  75                  80  


Lys Thr Val Asn Leu Ser Ile Pro Leu Ser Glu Thr Ser Ser Thr Lys 
                85                  90                  95      


Leu Ser His Ile Asp Glu Tyr Ile Ser Ser Ser Pro Thr Tyr Gln Thr 
            100                 105                 110         


Val Pro Asp Phe Gln Arg Val Gln Ile Thr Gly Asp Tyr Ala Ser Gly 
        115                 120                 125             


Val Thr Val Glu Asp Phe Glu Ile Val Cys Lys Gly Leu Tyr Arg Ala 
    130                 135                 140                 


Leu Cys Ile Arg Glu Lys Tyr Met Gln Lys Ser Phe Gln Arg Phe Pro 
145                 150                 155                 160 


Lys Thr Pro Ser Lys Tyr Leu Arg Asn Ile Asp Gly Glu Ala Trp Val 
                165                 170                 175     


Ala Asn Glu Ser Phe Tyr Pro Val Arg Pro Ile Pro Thr Gly Ala 
            180                 185                 190     


<210>  775
<211>  208
<212>  PRT
<213>  Homo Sapiens

<400>  775

Met Arg Ser Thr Ile Leu Leu Phe Cys Leu Leu Gly Ser Thr Arg Ser 
1               5                   10                  15      


Leu Pro Leu Lys Pro Ala Leu Gly Leu Pro Pro Thr Lys Leu Ala Pro 
            20                  25                  30          


Asp Gln Gly Thr Leu Pro Asn Gln Gln Gln Ser Asn Gln Val Phe Pro 
        35                  40                  45              


Ser Leu Ser Leu Ile Pro Leu Thr Gln Met Leu Thr Leu Gly Pro Asp 
    50                  55                  60                  


Leu His Leu Leu Asn Pro Ala Ala Gly Met Thr Pro Gly Thr Gln Thr 
65                  70                  75                  80  


His Pro Leu Thr Leu Gly Gly Leu Asn Val Gln Gln Gln Leu His Pro 
                85                  90                  95      


His Val Leu Pro Ile Phe Val Thr Gln Leu Gly Ala Gln Gly Thr Ile 
            100                 105                 110         


Leu Ser Ser Glu Glu Leu Pro Gln Ile Phe Thr Ser Leu Ile Ile His 
        115                 120                 125             


Ser Leu Phe Pro Gly Gly Ile Leu Pro Thr Ser Gln Ala Gly Ala Asn 
    130                 135                 140                 


Pro Asp Val Gln Asp Gly Ser Leu Pro Ala Gly Gly Ala Gly Val Asn 
145                 150                 155                 160 


Pro Ala Thr Gln Gly Thr Pro Ala Gly Arg Leu Pro Thr Pro Ser Gly 
                165                 170                 175     


Thr Asp Asp Asp Phe Ala Val Thr Thr Pro Ala Gly Ile Gln Arg Ser 
            180                 185                 190         


Thr His Ala Ile Glu Glu Ala Thr Thr Glu Ser Ala Asn Gly Ile Gln 
        195                 200                 205             


<210>  776
<211>  209
<212>  PRT
<213>  Homo Sapiens

<400>  776

Met Arg Ser Thr Ile Leu Leu Phe Cys Leu Leu Gly Ser Thr Arg Ser 
1               5                   10                  15      


Leu Pro Gln Leu Lys Pro Ala Leu Gly Leu Pro Pro Thr Lys Leu Ala 
            20                  25                  30          


Pro Asp Gln Gly Thr Leu Pro Asn Gln Gln Gln Ser Asn Gln Val Phe 
        35                  40                  45              


Pro Ser Leu Ser Leu Ile Pro Leu Thr Gln Met Leu Thr Leu Gly Pro 
    50                  55                  60                  


Asp Leu His Leu Leu Asn Pro Ala Ala Gly Met Thr Pro Gly Thr Gln 
65                  70                  75                  80  


Thr His Pro Leu Thr Leu Gly Gly Leu Asn Val Gln Gln Gln Leu His 
                85                  90                  95      


Pro His Val Leu Pro Ile Phe Val Thr Gln Leu Gly Ala Gln Gly Thr 
            100                 105                 110         


Ile Leu Ser Ser Glu Glu Leu Pro Gln Ile Phe Thr Ser Leu Ile Ile 
        115                 120                 125             


His Ser Leu Phe Pro Gly Gly Ile Leu Pro Thr Ser Gln Ala Gly Ala 
    130                 135                 140                 


Asn Pro Asp Val Gln Asp Gly Ser Leu Pro Ala Gly Gly Ala Gly Val 
145                 150                 155                 160 


Asn Pro Ala Thr Gln Gly Thr Pro Ala Gly Arg Leu Pro Thr Pro Ser 
                165                 170                 175     


Gly Thr Asp Asp Asp Phe Ala Val Thr Thr Pro Ala Gly Ile Gln Arg 
            180                 185                 190         


Ser Thr His Ala Ile Glu Glu Ala Thr Thr Glu Ser Ala Asn Gly Ile 
        195                 200                 205             


Gln 
    


<210>  777
<211>  105
<212>  PRT
<213>  Homo Sapiens

<400>  777

Met Lys Leu Phe Trp Leu Leu Phe Thr Ile Gly Phe Cys Trp Ala Gln 
1               5                   10                  15      


Tyr Ser Ser Asn Thr Gln Gln Gly Arg Thr Ser Ile Val His Leu Phe 
            20                  25                  30          


Glu Trp Arg Trp Val Asp Ile Ala Leu Glu Cys Glu Arg Tyr Leu Ala 
        35                  40                  45              


Pro Lys Gly Phe Gly Gly Val Gln Val Ser Pro Pro Asn Glu Asn Val 
    50                  55                  60                  


Ala Ile His Asn Pro Phe Arg Pro Trp Trp Glu Arg Tyr Gln Pro Val 
65                  70                  75                  80  


Ser Tyr Lys Leu Cys Thr Arg Ser Gly Asn Glu Asp Glu Phe Arg Asn 
                85                  90                  95      


Met Val Thr Arg Cys Asn Asn Val Gly 
            100                 105 


<210>  778
<211>  226
<212>  PRT
<213>  Homo Sapiens

<400>  778

Met Lys Leu Phe Trp Leu Leu Phe Thr Ile Gly Phe Cys Trp Ala Gln 
1               5                   10                  15      


Tyr Ser Ser Asn Thr Gln Gln Gly Arg Thr Ser Ile Val His Leu Phe 
            20                  25                  30          


Glu Trp Arg Trp Val Asp Ile Ala Leu Glu Cys Glu Arg Tyr Leu Ala 
        35                  40                  45              


Pro Lys Gly Phe Gly Gly Val Gln Val Ser Pro Pro Asn Glu Asn Val 
    50                  55                  60                  


Ala Ile His Asn Pro Phe Arg Pro Trp Trp Glu Arg Tyr Gln Pro Val 
65                  70                  75                  80  


Ser Tyr Lys Leu Cys Thr Arg Ser Gly Asn Glu Asp Glu Phe Arg Asn 
                85                  90                  95      


Met Val Thr Arg Cys Asn Asn Val Gly Val Arg Ile Tyr Val Asp Ala 
            100                 105                 110         


Val Ile Asn His Met Cys Gly Asn Ala Val Ser Ala Gly Thr Ser Ser 
        115                 120                 125             


Thr Cys Gly Ser Tyr Phe Asn Pro Gly Ser Arg Asp Phe Pro Ala Val 
    130                 135                 140                 


Pro Tyr Ser Gly Trp Asp Phe Asn Asp Gly Lys Cys Lys Thr Gly Ser 
145                 150                 155                 160 


Gly Asp Ile Glu Asn Tyr Asn Asp Ala Thr Gln Val Arg Asp Cys Arg 
                165                 170                 175     


Leu Ser Gly Leu Leu Asp Leu Ala Leu Gly Lys Asp Tyr Val Arg Ser 
            180                 185                 190         


Lys Ile Ala Glu Tyr Met Asn His Leu Ile Asp Ile Gly Val Ala Gly 
        195                 200                 205             


Phe Arg Ile Asp Ala Ser Lys His Met Trp Pro Gly Asp Ile Lys Ala 
    210                 215                 220                 


Ile Leu 
225     


<210>  779
<211>  511
<212>  PRT
<213>  Homo Sapiens

<400>  779

Met Lys Leu Phe Trp Leu Leu Phe Thr Ile Gly Phe Cys Trp Ala Gln 
1               5                   10                  15      


Tyr Ser Ser Asn Thr Gln Gln Gly Arg Thr Ser Ile Val His Leu Phe 
            20                  25                  30          


Glu Trp Arg Trp Val Asp Ile Ala Leu Glu Cys Glu Arg Tyr Leu Ala 
        35                  40                  45              


Pro Lys Gly Phe Gly Gly Val Gln Val Ser Pro Pro Asn Glu Asn Val 
    50                  55                  60                  


Ala Ile His Asn Pro Phe Arg Pro Trp Trp Glu Arg Tyr Gln Pro Val 
65                  70                  75                  80  


Ser Tyr Lys Leu Cys Thr Arg Ser Gly Asn Glu Asp Glu Phe Arg Asn 
                85                  90                  95      


Met Val Thr Arg Cys Asn Asn Val Gly Val Arg Ile Tyr Val Asp Ala 
            100                 105                 110         


Val Ile Asn His Met Cys Gly Asn Ala Val Ser Ala Gly Thr Ser Ser 
        115                 120                 125             


Thr Cys Gly Ser Tyr Phe Asn Pro Gly Ser Arg Asp Phe Pro Ala Val 
    130                 135                 140                 


Pro Tyr Ser Gly Trp Asp Phe Asn Asp Gly Lys Cys Lys Thr Gly Ser 
145                 150                 155                 160 


Gly Asp Ile Glu Asn Tyr Asn Asp Ala Thr Gln Val Arg Asp Cys Arg 
                165                 170                 175     


Leu Ser Gly Leu Leu Asp Leu Ala Leu Gly Lys Asp Tyr Val Arg Ser 
            180                 185                 190         


Lys Ile Ala Glu Tyr Met Asn His Leu Ile Asp Ile Gly Val Ala Gly 
        195                 200                 205             


Phe Arg Ile Asp Ala Ser Lys His Met Trp Pro Gly Asp Ile Lys Ala 
    210                 215                 220                 


Ile Leu Asp Lys Leu His Asn Leu Asn Ser Asn Trp Phe Pro Glu Gly 
225                 230                 235                 240 


Ser Lys Pro Phe Ile Tyr Gln Glu Val Ile Asp Leu Gly Gly Glu Pro 
                245                 250                 255     


Ile Lys Ser Ser Asp Tyr Phe Gly Asn Gly Arg Val Thr Glu Phe Lys 
            260                 265                 270         


Tyr Gly Ala Lys Leu Gly Thr Val Ile Arg Lys Trp Asn Gly Glu Lys 
        275                 280                 285             


Met Ser Tyr Leu Lys Asn Trp Gly Glu Gly Trp Gly Phe Met Pro Ser 
    290                 295                 300                 


Asp Arg Ala Leu Val Phe Val Asp Asn His Asp Asn Gln Arg Gly His 
305                 310                 315                 320 


Gly Ala Gly Gly Ala Ser Ile Leu Thr Phe Trp Asp Ala Arg Leu Tyr 
                325                 330                 335     


Lys Met Ala Val Gly Phe Met Leu Ala His Pro Tyr Gly Phe Thr Arg 
            340                 345                 350         


Val Met Ser Ser Tyr Arg Trp Pro Arg Tyr Phe Glu Asn Gly Lys Asp 
        355                 360                 365             


Val Asn Asp Trp Val Gly Pro Pro Asn Asp Asn Gly Val Thr Lys Glu 
    370                 375                 380                 


Val Thr Ile Asn Pro Asp Thr Thr Cys Gly Asn Asp Trp Val Cys Glu 
385                 390                 395                 400 


His Arg Trp Arg Gln Ile Arg Asn Met Val Asn Phe Arg Asn Val Val 
                405                 410                 415     


Asp Gly Gln Pro Phe Thr Asn Trp Tyr Asp Asn Gly Ser Asn Gln Val 
            420                 425                 430         


Ala Phe Gly Arg Gly Asn Arg Gly Phe Ile Val Phe Asn Asn Asp Asp 
        435                 440                 445             


Trp Thr Phe Ser Leu Thr Leu Gln Thr Gly Leu Pro Ala Gly Thr Tyr 
    450                 455                 460                 


Cys Asp Val Ile Ser Gly Asp Lys Ile Asn Gly Asn Cys Thr Gly Ile 
465                 470                 475                 480 


Lys Ile Tyr Val Ser Asp Asp Gly Lys Ala His Phe Ser Ile Ser Asn 
                485                 490                 495     


Ser Ala Glu Asp Pro Phe Ile Ala Ile His Ala Glu Ser Lys Leu 
            500                 505                 510     


<210>  780
<211>  105
<212>  PRT
<213>  Homo Sapiens

<400>  780

Met Lys Leu Phe Trp Leu Leu Phe Thr Ile Gly Phe Cys Trp Ala Gln 
1               5                   10                  15      


Tyr Ser Ser Asn Thr Gln Gln Gly Arg Thr Ser Ile Val His Leu Phe 
            20                  25                  30          


Glu Trp Arg Trp Val Asp Ile Ala Leu Glu Cys Glu Arg Tyr Leu Ala 
        35                  40                  45              


Pro Lys Gly Phe Gly Gly Val Gln Val Ser Pro Pro Asn Glu Asn Val 
    50                  55                  60                  


Ala Ile His Asn Pro Phe Arg Pro Trp Trp Glu Arg Tyr Gln Pro Val 
65                  70                  75                  80  


Ser Tyr Lys Leu Cys Thr Arg Ser Gly Asn Glu Asp Glu Phe Arg Asn 
                85                  90                  95      


Met Val Thr Arg Cys Asn Asn Val Gly 
            100                 105 


<210>  781
<211>  226
<212>  PRT
<213>  Homo Sapiens

<400>  781

Met Lys Leu Phe Trp Leu Leu Phe Thr Ile Gly Phe Cys Trp Ala Gln 
1               5                   10                  15      


Tyr Ser Ser Asn Thr Gln Gln Gly Arg Thr Ser Ile Val His Leu Phe 
            20                  25                  30          


Glu Trp Arg Trp Val Asp Ile Ala Leu Glu Cys Glu Arg Tyr Leu Ala 
        35                  40                  45              


Pro Lys Gly Phe Gly Gly Val Gln Val Ser Pro Pro Asn Glu Asn Val 
    50                  55                  60                  


Ala Ile His Asn Pro Phe Arg Pro Trp Trp Glu Arg Tyr Gln Pro Val 
65                  70                  75                  80  


Ser Tyr Lys Leu Cys Thr Arg Ser Gly Asn Glu Asp Glu Phe Arg Asn 
                85                  90                  95      


Met Val Thr Arg Cys Asn Asn Val Gly Val Arg Ile Tyr Val Asp Ala 
            100                 105                 110         


Val Ile Asn His Met Cys Gly Asn Ala Val Ser Ala Gly Thr Ser Ser 
        115                 120                 125             


Thr Cys Gly Ser Tyr Phe Asn Pro Gly Ser Arg Asp Phe Pro Ala Val 
    130                 135                 140                 


Pro Tyr Ser Gly Trp Asp Phe Asn Asp Gly Lys Cys Lys Thr Gly Ser 
145                 150                 155                 160 


Gly Asp Ile Glu Asn Tyr Asn Asp Ala Thr Gln Val Arg Asp Cys Arg 
                165                 170                 175     


Leu Ser Gly Leu Leu Asp Leu Ala Leu Gly Lys Asp Tyr Val Arg Ser 
            180                 185                 190         


Lys Ile Ala Glu Tyr Met Asn His Leu Ile Asp Ile Gly Val Ala Gly 
        195                 200                 205             


Phe Arg Ile Asp Ala Ser Lys His Met Trp Pro Gly Asp Ile Lys Ala 
    210                 215                 220                 


Ile Leu 
225     


<210>  782
<211>  511
<212>  PRT
<213>  Homo Sapiens

<400>  782

Met Lys Leu Phe Trp Leu Leu Phe Thr Ile Gly Phe Cys Trp Ala Gln 
1               5                   10                  15      


Tyr Ser Ser Asn Thr Gln Gln Gly Arg Thr Ser Ile Val His Leu Phe 
            20                  25                  30          


Glu Trp Arg Trp Val Asp Ile Ala Leu Glu Cys Glu Arg Tyr Leu Ala 
        35                  40                  45              


Pro Lys Gly Phe Gly Gly Val Gln Val Ser Pro Pro Asn Glu Asn Val 
    50                  55                  60                  


Ala Ile His Asn Pro Phe Arg Pro Trp Trp Glu Arg Tyr Gln Pro Val 
65                  70                  75                  80  


Ser Tyr Lys Leu Cys Thr Arg Ser Gly Asn Glu Asp Glu Phe Arg Asn 
                85                  90                  95      


Met Val Thr Arg Cys Asn Asn Val Gly Val Arg Ile Tyr Val Asp Ala 
            100                 105                 110         


Val Ile Asn His Met Cys Gly Asn Ala Val Ser Ala Gly Thr Ser Ser 
        115                 120                 125             


Thr Cys Gly Ser Tyr Phe Asn Pro Gly Ser Arg Asp Phe Pro Ala Val 
    130                 135                 140                 


Pro Tyr Ser Gly Trp Asp Phe Asn Asp Gly Lys Cys Lys Thr Gly Ser 
145                 150                 155                 160 


Gly Asp Ile Glu Asn Tyr Asn Asp Ala Thr Gln Val Arg Asp Cys Arg 
                165                 170                 175     


Leu Ser Gly Leu Leu Asp Leu Ala Leu Gly Lys Asp Tyr Val Arg Ser 
            180                 185                 190         


Lys Ile Ala Glu Tyr Met Asn His Leu Ile Asp Ile Gly Val Ala Gly 
        195                 200                 205             


Phe Arg Ile Asp Ala Ser Lys His Met Trp Pro Gly Asp Ile Lys Ala 
    210                 215                 220                 


Ile Leu Asp Lys Leu His Asn Leu Asn Ser Asn Trp Phe Pro Glu Gly 
225                 230                 235                 240 


Ser Lys Pro Phe Ile Tyr Gln Glu Val Ile Asp Leu Gly Gly Glu Pro 
                245                 250                 255     


Ile Lys Ser Ser Asp Tyr Phe Gly Asn Gly Arg Val Thr Glu Phe Lys 
            260                 265                 270         


Tyr Gly Ala Lys Leu Gly Thr Val Ile Arg Lys Trp Asn Gly Glu Lys 
        275                 280                 285             


Met Ser Tyr Leu Lys Asn Trp Gly Glu Gly Trp Gly Phe Met Pro Ser 
    290                 295                 300                 


Asp Arg Ala Leu Val Phe Val Asp Asn His Asp Asn Gln Arg Gly His 
305                 310                 315                 320 


Gly Ala Gly Gly Ala Ser Ile Leu Thr Phe Trp Asp Ala Arg Leu Tyr 
                325                 330                 335     


Lys Met Ala Val Gly Phe Met Leu Ala His Pro Tyr Gly Phe Thr Arg 
            340                 345                 350         


Val Met Ser Ser Tyr Arg Trp Pro Arg Tyr Phe Glu Asn Gly Lys Asp 
        355                 360                 365             


Val Asn Asp Trp Val Gly Pro Pro Asn Asp Asn Gly Val Thr Lys Glu 
    370                 375                 380                 


Val Thr Ile Asn Pro Asp Thr Thr Cys Gly Asn Asp Trp Val Cys Glu 
385                 390                 395                 400 


His Arg Trp Arg Gln Ile Arg Asn Met Val Asn Phe Arg Asn Val Val 
                405                 410                 415     


Asp Gly Gln Pro Phe Thr Asn Trp Tyr Asp Asn Gly Ser Asn Gln Val 
            420                 425                 430         


Ala Phe Gly Arg Gly Asn Arg Gly Phe Ile Val Phe Asn Asn Asp Asp 
        435                 440                 445             


Trp Thr Phe Ser Leu Thr Leu Gln Thr Gly Leu Pro Ala Gly Thr Tyr 
    450                 455                 460                 


Cys Asp Val Ile Ser Gly Asp Lys Ile Asn Gly Asn Cys Thr Gly Ile 
465                 470                 475                 480 


Lys Ile Tyr Val Ser Asp Asp Gly Lys Ala His Phe Ser Ile Ser Asn 
                485                 490                 495     


Ser Ala Glu Asp Pro Phe Ile Ala Ile His Ala Glu Ser Lys Leu 
            500                 505                 510     


<210>  783
<211>  511
<212>  PRT
<213>  Homo Sapiens

<400>  783

Met Lys Leu Phe Trp Leu Leu Phe Thr Ile Gly Phe Cys Trp Ala Gln 
1               5                   10                  15      


Tyr Ser Ser Asn Thr Gln Gln Gly Arg Thr Ser Ile Val His Leu Phe 
            20                  25                  30          


Glu Trp Arg Trp Val Asp Ile Ala Leu Glu Cys Glu Arg Tyr Leu Ala 
        35                  40                  45              


Pro Lys Gly Phe Gly Gly Val Gln Val Ser Pro Pro Asn Glu Asn Val 
    50                  55                  60                  


Ala Ile His Asn Pro Phe Arg Pro Trp Trp Glu Arg Tyr Gln Pro Val 
65                  70                  75                  80  


Ser Tyr Lys Leu Cys Thr Arg Ser Gly Asn Glu Asp Glu Phe Arg Asn 
                85                  90                  95      


Met Val Thr Arg Cys Asn Asn Val Gly Val Arg Ile Tyr Val Asp Ala 
            100                 105                 110         


Val Ile Asn His Met Cys Gly Asn Ala Val Ser Ala Gly Thr Ser Ser 
        115                 120                 125             


Thr Cys Gly Ser Tyr Phe Asn Pro Gly Ser Arg Asp Phe Pro Ala Val 
    130                 135                 140                 


Pro Tyr Ser Gly Trp Asp Phe Asn Asp Gly Lys Cys Lys Thr Gly Ser 
145                 150                 155                 160 


Gly Asp Ile Glu Asn Tyr Asn Asp Ala Thr Gln Val Arg Asp Cys Arg 
                165                 170                 175     


Leu Ser Gly Leu Leu Asp Leu Ala Leu Gly Lys Asp Tyr Val Arg Ser 
            180                 185                 190         


Lys Ile Ala Glu Tyr Met Asn His Leu Ile Asp Ile Gly Val Ala Gly 
        195                 200                 205             


Phe Arg Ile Asp Ala Ser Lys His Met Trp Pro Gly Asp Ile Lys Ala 
    210                 215                 220                 


Ile Leu Asp Lys Leu His Asn Leu Asn Ser Asn Trp Phe Pro Glu Gly 
225                 230                 235                 240 


Ser Lys Pro Phe Ile Tyr Gln Glu Val Ile Asp Leu Gly Gly Glu Pro 
                245                 250                 255     


Ile Lys Ser Ser Asp Tyr Phe Gly Asn Gly Arg Val Thr Glu Phe Lys 
            260                 265                 270         


Tyr Gly Ala Lys Leu Gly Thr Val Ile Arg Lys Trp Asn Gly Glu Lys 
        275                 280                 285             


Met Ser Tyr Leu Lys Asn Trp Gly Glu Gly Trp Gly Phe Met Pro Ser 
    290                 295                 300                 


Asp Arg Ala Leu Val Phe Val Asp Asn His Asp Asn Gln Arg Gly His 
305                 310                 315                 320 


Gly Ala Gly Gly Ala Ser Ile Leu Thr Phe Trp Asp Ala Arg Leu Tyr 
                325                 330                 335     


Lys Met Ala Val Gly Phe Met Leu Ala His Pro Tyr Gly Phe Thr Arg 
            340                 345                 350         


Val Met Ser Ser Tyr Arg Trp Pro Arg Tyr Phe Glu Asn Gly Lys Asp 
        355                 360                 365             


Val Asn Asp Trp Val Gly Pro Pro Asn Asp Asn Gly Val Thr Lys Glu 
    370                 375                 380                 


Val Thr Ile Asn Pro Asp Thr Thr Cys Gly Asn Asp Trp Val Cys Glu 
385                 390                 395                 400 


His Arg Trp Arg Gln Ile Arg Asn Met Val Asn Phe Arg Asn Val Val 
                405                 410                 415     


Asp Gly Gln Pro Phe Thr Asn Trp Tyr Asp Asn Gly Ser Asn Gln Val 
            420                 425                 430         


Ala Phe Gly Arg Gly Asn Arg Gly Phe Ile Val Phe Asn Asn Asp Asp 
        435                 440                 445             


Trp Thr Phe Ser Leu Thr Leu Gln Thr Gly Leu Pro Ala Gly Thr Tyr 
    450                 455                 460                 


Cys Asp Val Ile Ser Gly Asp Lys Ile Asn Gly Asn Cys Thr Gly Ile 
465                 470                 475                 480 


Lys Ile Tyr Val Ser Asp Asp Gly Lys Ala His Phe Ser Ile Ser Asn 
                485                 490                 495     


Ser Ala Glu Asp Pro Phe Ile Ala Ile His Ala Glu Ser Lys Leu 
            500                 505                 510     


<210>  784
<211>  511
<212>  PRT
<213>  Homo Sapiens

<400>  784

Met Lys Leu Phe Trp Leu Leu Phe Thr Ile Gly Phe Cys Trp Ala Gln 
1               5                   10                  15      


Tyr Ser Ser Asn Thr Gln Gln Gly Arg Thr Ser Ile Val His Leu Phe 
            20                  25                  30          


Glu Trp Arg Trp Val Asp Ile Ala Leu Glu Cys Glu Arg Tyr Leu Ala 
        35                  40                  45              


Pro Lys Gly Phe Gly Gly Val Gln Val Ser Pro Pro Asn Glu Asn Val 
    50                  55                  60                  


Ala Ile His Asn Pro Phe Arg Pro Trp Trp Glu Arg Tyr Gln Pro Val 
65                  70                  75                  80  


Ser Tyr Lys Leu Cys Thr Arg Ser Gly Asn Glu Asp Glu Phe Arg Asn 
                85                  90                  95      


Met Val Thr Arg Cys Asn Asn Val Gly Val Arg Ile Tyr Val Asp Ala 
            100                 105                 110         


Val Ile Asn His Met Cys Gly Asn Ala Val Ser Ala Gly Thr Ser Ser 
        115                 120                 125             


Thr Cys Gly Ser Tyr Phe Asn Pro Gly Ser Arg Asp Phe Pro Ala Val 
    130                 135                 140                 


Pro Tyr Ser Gly Trp Asp Phe Asn Asp Gly Lys Cys Lys Thr Gly Ser 
145                 150                 155                 160 


Gly Asp Ile Glu Asn Tyr Asn Asp Ala Thr Gln Val Arg Asp Cys Arg 
                165                 170                 175     


Leu Ser Gly Leu Leu Asp Leu Ala Leu Gly Lys Asp Tyr Val Arg Ser 
            180                 185                 190         


Lys Ile Ala Glu Tyr Met Asn His Leu Ile Asp Ile Gly Val Ala Gly 
        195                 200                 205             


Phe Arg Ile Asp Ala Ser Lys His Met Trp Pro Gly Asp Ile Lys Ala 
    210                 215                 220                 


Ile Leu Asp Lys Leu His Asn Leu Asn Ser Asn Trp Phe Pro Glu Gly 
225                 230                 235                 240 


Ser Lys Pro Phe Ile Tyr Gln Glu Val Ile Asp Leu Gly Gly Glu Pro 
                245                 250                 255     


Ile Lys Ser Ser Asp Tyr Phe Gly Asn Gly Arg Val Thr Glu Phe Lys 
            260                 265                 270         


Tyr Gly Ala Lys Leu Gly Thr Val Ile Arg Lys Trp Asn Gly Glu Lys 
        275                 280                 285             


Met Ser Tyr Leu Lys Asn Trp Gly Glu Gly Trp Gly Phe Met Pro Ser 
    290                 295                 300                 


Asp Arg Ala Leu Val Phe Val Asp Asn His Asp Asn Gln Arg Gly His 
305                 310                 315                 320 


Gly Ala Gly Gly Ala Ser Ile Leu Thr Phe Trp Asp Ala Arg Leu Tyr 
                325                 330                 335     


Lys Met Ala Val Gly Phe Met Leu Ala His Pro Tyr Gly Phe Thr Arg 
            340                 345                 350         


Val Met Ser Ser Tyr Arg Trp Pro Arg Tyr Phe Glu Asn Gly Lys Asp 
        355                 360                 365             


Val Asn Asp Trp Val Gly Pro Pro Asn Asp Asn Gly Val Thr Lys Glu 
    370                 375                 380                 


Val Thr Ile Asn Pro Asp Thr Thr Cys Gly Asn Asp Trp Val Cys Glu 
385                 390                 395                 400 


His Arg Trp Arg Gln Ile Arg Asn Met Val Asn Phe Arg Asn Val Val 
                405                 410                 415     


Asp Gly Gln Pro Phe Thr Asn Trp Tyr Asp Asn Gly Ser Asn Gln Val 
            420                 425                 430         


Ala Phe Gly Arg Gly Asn Arg Gly Phe Ile Val Phe Asn Asn Asp Asp 
        435                 440                 445             


Trp Thr Phe Ser Leu Thr Leu Gln Thr Gly Leu Pro Ala Gly Thr Tyr 
    450                 455                 460                 


Cys Asp Val Ile Ser Gly Asp Lys Ile Asn Gly Asn Cys Thr Gly Ile 
465                 470                 475                 480 


Lys Ile Tyr Val Ser Asp Asp Gly Lys Ala His Phe Ser Ile Ser Asn 
                485                 490                 495     


Ser Ala Glu Asp Pro Phe Ile Ala Ile His Ala Glu Ser Lys Leu 
            500                 505                 510     


<210>  785
<211>  511
<212>  PRT
<213>  Homo Sapiens

<400>  785

Met Lys Phe Phe Leu Leu Leu Phe Thr Ile Gly Phe Cys Trp Ala Gln 
1               5                   10                  15      


Tyr Ser Pro Asn Thr Gln Gln Gly Arg Thr Ser Ile Val His Leu Phe 
            20                  25                  30          


Glu Trp Arg Trp Val Asp Ile Ala Leu Glu Cys Glu Arg Tyr Leu Ala 
        35                  40                  45              


Pro Lys Gly Phe Gly Gly Val Gln Val Ser Pro Pro Asn Glu Asn Val 
    50                  55                  60                  


Ala Ile Tyr Asn Pro Phe Arg Pro Trp Trp Glu Arg Tyr Gln Pro Val 
65                  70                  75                  80  


Ser Tyr Lys Leu Cys Thr Arg Ser Gly Asn Glu Asp Glu Phe Arg Asn 
                85                  90                  95      


Met Val Thr Arg Cys Asn Asn Val Gly Val Arg Ile Tyr Val Asp Ala 
            100                 105                 110         


Val Ile Asn His Met Cys Gly Asn Ala Val Ser Ala Gly Thr Ser Ser 
        115                 120                 125             


Thr Cys Gly Ser Tyr Phe Asn Pro Gly Ser Arg Asp Phe Pro Ala Val 
    130                 135                 140                 


Pro Tyr Ser Gly Trp Asp Phe Asn Asp Gly Lys Cys Lys Thr Gly Ser 
145                 150                 155                 160 


Gly Asp Ile Glu Asn Tyr Asn Asp Ala Thr Gln Val Arg Asp Cys Arg 
                165                 170                 175     


Leu Thr Gly Leu Leu Asp Leu Ala Leu Glu Lys Asp Tyr Val Arg Ser 
            180                 185                 190         


Lys Ile Ala Glu Tyr Met Asn His Leu Ile Asp Ile Gly Val Ala Gly 
        195                 200                 205             


Phe Arg Leu Asp Ala Ser Lys His Met Trp Pro Gly Asp Ile Lys Ala 
    210                 215                 220                 


Ile Leu Asp Lys Leu His Asn Leu Asn Ser Asn Trp Phe Pro Ala Gly 
225                 230                 235                 240 


Ser Lys Pro Phe Ile Tyr Gln Glu Val Ile Asp Leu Gly Gly Glu Pro 
                245                 250                 255     


Ile Lys Ser Ser Asp Tyr Phe Gly Asn Gly Arg Val Thr Glu Phe Lys 
            260                 265                 270         


Tyr Gly Ala Lys Leu Gly Thr Val Ile Arg Lys Trp Asn Gly Glu Lys 
        275                 280                 285             


Met Ser Tyr Leu Lys Asn Trp Gly Glu Gly Trp Gly Phe Val Pro Ser 
    290                 295                 300                 


Asp Arg Ala Leu Val Phe Val Asp Asn His Asp Asn Gln Arg Gly His 
305                 310                 315                 320 


Gly Ala Gly Gly Ala Ser Ile Leu Thr Phe Trp Asp Ala Arg Leu Tyr 
                325                 330                 335     


Lys Met Ala Val Gly Phe Met Leu Ala His Pro Tyr Gly Phe Thr Arg 
            340                 345                 350         


Val Met Ser Ser Tyr Arg Trp Pro Arg Gln Phe Gln Asn Gly Asn Asp 
        355                 360                 365             


Val Asn Asp Trp Val Gly Pro Pro Asn Asn Asn Gly Val Ile Lys Glu 
    370                 375                 380                 


Val Thr Ile Asn Pro Asp Thr Thr Cys Gly Asn Asp Trp Val Cys Glu 
385                 390                 395                 400 


His Arg Trp Arg Gln Ile Arg Asn Met Val Ile Phe Arg Asn Val Val 
                405                 410                 415     


Asp Gly Gln Pro Phe Thr Asn Trp Tyr Asp Asn Gly Ser Asn Gln Val 
            420                 425                 430         


Ala Phe Gly Arg Gly Asn Arg Gly Phe Ile Val Phe Asn Asn Asp Asp 
        435                 440                 445             


Trp Ser Phe Ser Leu Thr Leu Gln Thr Gly Leu Pro Ala Gly Thr Tyr 
    450                 455                 460                 


Cys Asp Val Ile Ser Gly Asp Lys Ile Asn Gly Asn Cys Thr Gly Ile 
465                 470                 475                 480 


Lys Ile Tyr Val Ser Asp Asp Gly Lys Ala His Phe Ser Ile Ser Asn 
                485                 490                 495     


Ser Ala Glu Asp Pro Phe Ile Ala Ile His Ala Glu Ser Lys Leu 
            500                 505                 510     


<210>  786
<211>  511
<212>  PRT
<213>  Homo Sapiens

<400>  786

Met Lys Phe Phe Leu Leu Leu Phe Thr Ile Gly Phe Cys Trp Ala Gln 
1               5                   10                  15      


Tyr Ser Pro Asn Thr Gln Gln Gly Arg Thr Ser Ile Val His Leu Phe 
            20                  25                  30          


Glu Trp Arg Trp Val Asp Ile Ala Leu Glu Cys Glu Arg Tyr Leu Ala 
        35                  40                  45              


Pro Lys Gly Phe Gly Gly Val Gln Val Ser Pro Pro Asn Glu Asn Val 
    50                  55                  60                  


Ala Ile Tyr Asn Pro Phe Arg Pro Trp Trp Glu Arg Tyr Gln Pro Val 
65                  70                  75                  80  


Ser Tyr Lys Leu Cys Thr Arg Ser Gly Asn Glu Asp Glu Phe Arg Asn 
                85                  90                  95      


Met Val Thr Arg Cys Asn Asn Val Gly Val Arg Ile Tyr Val Asp Ala 
            100                 105                 110         


Val Ile Asn His Met Cys Gly Asn Ala Val Ser Ala Gly Thr Ser Ser 
        115                 120                 125             


Thr Cys Gly Ser Tyr Phe Asn Pro Gly Ser Arg Asp Phe Pro Ala Val 
    130                 135                 140                 


Pro Tyr Ser Gly Trp Asp Phe Asn Asp Gly Lys Cys Lys Thr Gly Ser 
145                 150                 155                 160 


Gly Asp Ile Glu Asn Tyr Asn Asp Ala Thr Gln Val Arg Asp Cys Arg 
                165                 170                 175     


Leu Thr Gly Leu Leu Asp Leu Ala Leu Glu Lys Asp Tyr Val Arg Ser 
            180                 185                 190         


Lys Ile Ala Glu Tyr Met Asn His Leu Ile Asp Ile Gly Val Ala Gly 
        195                 200                 205             


Phe Arg Leu Asp Ala Ser Lys His Met Trp Pro Gly Asp Ile Lys Ala 
    210                 215                 220                 


Ile Leu Asp Lys Leu His Asn Leu Asn Ser Asn Trp Phe Pro Ala Gly 
225                 230                 235                 240 


Ser Lys Pro Phe Ile Tyr Gln Glu Val Ile Asp Leu Gly Gly Glu Pro 
                245                 250                 255     


Ile Lys Ser Ser Asp Tyr Phe Gly Asn Gly Arg Val Thr Glu Phe Lys 
            260                 265                 270         


Tyr Gly Ala Lys Leu Gly Thr Val Ile Arg Lys Trp Asn Gly Glu Lys 
        275                 280                 285             


Met Ser Tyr Leu Lys Asn Trp Gly Glu Gly Trp Gly Phe Val Pro Ser 
    290                 295                 300                 


Asp Arg Ala Leu Val Phe Val Asp Asn His Asp Asn Gln Arg Gly His 
305                 310                 315                 320 


Gly Ala Gly Gly Ala Ser Ile Leu Thr Phe Trp Asp Ala Arg Leu Tyr 
                325                 330                 335     


Lys Met Ala Val Gly Phe Met Leu Ala His Pro Tyr Gly Phe Thr Arg 
            340                 345                 350         


Val Met Ser Ser Tyr Arg Trp Pro Arg Gln Phe Gln Asn Gly Asn Asp 
        355                 360                 365             


Val Asn Asp Trp Val Gly Pro Pro Asn Asn Asn Gly Val Ile Lys Glu 
    370                 375                 380                 


Val Thr Ile Asn Pro Asp Thr Thr Cys Gly Asn Asp Trp Val Cys Glu 
385                 390                 395                 400 


His Arg Trp Arg Gln Ile Arg Asn Met Val Ile Phe Arg Asn Val Val 
                405                 410                 415     


Asp Gly Gln Pro Phe Thr Asn Trp Tyr Asp Asn Gly Ser Asn Gln Val 
            420                 425                 430         


Ala Phe Gly Arg Gly Asn Arg Gly Phe Ile Val Phe Asn Asn Asp Asp 
        435                 440                 445             


Trp Ser Phe Ser Leu Thr Leu Gln Thr Gly Leu Pro Ala Gly Thr Tyr 
    450                 455                 460                 


Cys Asp Val Ile Ser Gly Asp Lys Ile Asn Gly Asn Cys Thr Gly Ile 
465                 470                 475                 480 


Lys Ile Tyr Val Ser Asp Asp Gly Lys Ala His Phe Ser Ile Ser Asn 
                485                 490                 495     


Ser Ala Glu Asp Pro Phe Ile Ala Ile His Ala Glu Ser Lys Leu 
            500                 505                 510     


<210>  787
<211>  209
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  787

Xaa Phe Phe Leu Leu Leu Phe Thr Ile Gly Phe Cys Trp Ala Gln Tyr 
1               5                   10                  15      


Ser Pro Asn Thr Gln Gln Gly Arg Thr Ser Ile Val His Leu Phe Glu 
            20                  25                  30          


Trp Arg Trp Val Asp Ile Ala Leu Glu Cys Glu Arg Tyr Leu Ala Pro 
        35                  40                  45              


Lys Gly Phe Gly Gly Val Gln Val Ser Pro Pro Asn Glu Asn Val Ala 
    50                  55                  60                  


Ile Tyr Asn Pro Phe Arg Pro Trp Trp Glu Arg Tyr Gln Pro Val Ser 
65                  70                  75                  80  


Tyr Lys Leu Cys Thr Arg Ser Gly Asn Glu Asp Glu Phe Arg Asn Met 
                85                  90                  95      


Val Thr Arg Cys Asn Asn Val Gly Val Arg Ile Tyr Val Asp Ala Val 
            100                 105                 110         


Ile Asn His Met Cys Gly Asn Ala Val Ser Ala Gly Thr Ser Ser Thr 
        115                 120                 125             


Cys Gly Ser Tyr Phe Asn Pro Gly Ser Arg Asp Phe Pro Ala Val Pro 
    130                 135                 140                 


Tyr Ser Gly Trp Asp Phe Asn Asp Gly Lys Cys Lys Thr Gly Ser Gly 
145                 150                 155                 160 


Asp Ile Glu Asn Tyr Asn Asp Ala Thr Gln Val Ile Asp Leu Gly Gly 
                165                 170                 175     


Glu Pro Ile Lys Ser Ser Asp Tyr Phe Gly Asn Gly Arg Val Thr Glu 
            180                 185                 190         


Phe Lys Tyr Gly Ala Lys Leu Gly Thr Val Ile Arg Lys Trp Asn Gly 
        195                 200                 205             


Glu 
    


<210>  788
<211>  86
<212>  PRT
<213>  Homo Sapiens

<400>  788

Met Lys Phe Phe Leu Leu Leu Phe Thr Ile Gly Phe Cys Trp Ala Gln 
1               5                   10                  15      


Tyr Ser Pro Asn Thr Gln Gln Gly Arg Thr Ser Ile Val His Leu Phe 
            20                  25                  30          


Glu Trp Arg Trp Val Asp Ile Ala Leu Glu Cys Glu Arg Tyr Leu Ala 
        35                  40                  45              


Pro Lys Gly Phe Gly Gly Val Gln Val Ser Pro Pro Asn Glu Asn Val 
    50                  55                  60                  


Ala Ile His Asn Pro Phe Arg Pro Trp Trp Glu Arg Tyr Gln Pro Val 
65                  70                  75                  80  


Ser Tyr Lys Leu Cys Thr 
                85      


<210>  789
<211>  96
<212>  PRT
<213>  Homo Sapiens

<400>  789

Met Lys Phe Phe Leu Leu Leu Phe Thr Ile Gly Phe Cys Trp Ala Gln 
1               5                   10                  15      


Tyr Ser Pro Asn Thr Gln Gln Gly Arg Thr Ser Ile Val His Leu Phe 
            20                  25                  30          


Glu Trp Arg Trp Val Asp Ile Ala Leu Glu Cys Glu Arg Tyr Leu Ala 
        35                  40                  45              


Pro Lys Gly Phe Gly Gly Val Gln Val Ser Pro Pro Asn Glu Asn Val 
    50                  55                  60                  


Ala Ile His Asn Pro Phe Arg Pro Trp Trp Glu Arg Tyr Gln Pro Val 
65                  70                  75                  80  


Ser Tyr Lys Leu Cys Thr Arg Ser Gly Asn Glu Asp Glu Phe Arg Asn 
                85                  90                  95      


<210>  790
<211>  511
<212>  PRT
<213>  Homo Sapiens

<400>  790

Met Lys Phe Phe Leu Leu Leu Phe Thr Ile Gly Phe Cys Trp Ala Gln 
1               5                   10                  15      


Tyr Ser Pro Asn Thr Gln Gln Gly Arg Thr Ser Ile Val His Leu Phe 
            20                  25                  30          


Glu Trp Arg Trp Val Asp Ile Ala Leu Glu Cys Glu Arg Tyr Leu Ala 
        35                  40                  45              


Pro Lys Gly Phe Gly Gly Val Gln Val Ser Pro Pro Asn Glu Asn Val 
    50                  55                  60                  


Ala Ile His Asn Pro Phe Arg Pro Trp Trp Glu Arg Tyr Gln Pro Val 
65                  70                  75                  80  


Ser Tyr Lys Leu Cys Thr Arg Ser Gly Asn Glu Asp Glu Phe Arg Asn 
                85                  90                  95      


Met Val Thr Arg Cys Asn Asn Val Gly Val Arg Ile Tyr Val Asp Ala 
            100                 105                 110         


Val Ile Asn His Met Ser Gly Asn Ala Val Ser Ala Gly Thr Ser Ser 
        115                 120                 125             


Thr Cys Gly Ser Tyr Phe Asn Pro Gly Ser Arg Asp Phe Pro Ala Val 
    130                 135                 140                 


Pro Tyr Ser Gly Trp Asp Phe Asn Asp Gly Lys Cys Lys Thr Gly Ser 
145                 150                 155                 160 


Gly Asp Ile Glu Asn Tyr Asn Asp Ala Thr Gln Val Arg Asp Cys Arg 
                165                 170                 175     


Leu Val Gly Leu Leu Asp Leu Ala Leu Glu Lys Asp Tyr Val Arg Ser 
            180                 185                 190         


Lys Ile Ala Glu Tyr Met Asn His Leu Ile Asp Ile Gly Val Ala Gly 
        195                 200                 205             


Phe Arg Leu Asp Ala Ser Lys His Met Trp Pro Gly Asp Ile Lys Ala 
    210                 215                 220                 


Ile Leu Asp Lys Leu His Asn Leu Asn Ser Asn Trp Phe Pro Ala Gly 
225                 230                 235                 240 


Ser Lys Pro Phe Ile Tyr Gln Glu Val Ile Asp Leu Gly Gly Glu Pro 
                245                 250                 255     


Ile Lys Ser Ser Asp Tyr Phe Gly Asn Gly Arg Val Thr Glu Phe Lys 
            260                 265                 270         


Tyr Gly Ala Lys Leu Gly Thr Val Ile Arg Lys Trp Asn Gly Glu Lys 
        275                 280                 285             


Met Ser Tyr Leu Lys Asn Trp Gly Glu Gly Trp Gly Phe Met Pro Ser 
    290                 295                 300                 


Asp Arg Ala Leu Val Phe Val Asp Asn His Asp Asn Gln Arg Gly His 
305                 310                 315                 320 


Gly Ala Gly Gly Ala Ser Ile Leu Thr Phe Trp Asp Ala Arg Leu Tyr 
                325                 330                 335     


Lys Met Ala Val Gly Phe Met Leu Ala His Pro Tyr Gly Phe Thr Arg 
            340                 345                 350         


Val Met Ser Ser Tyr Arg Trp Pro Arg Gln Phe Gln Asn Gly Asn Asp 
        355                 360                 365             


Val Asn Asp Trp Val Gly Pro Pro Asn Asn Asn Gly Val Ile Lys Glu 
    370                 375                 380                 


Val Thr Ile Asn Pro Asp Thr Thr Cys Gly Asn Asp Trp Val Cys Glu 
385                 390                 395                 400 


His Arg Trp Arg Gln Ile Arg Asn Met Val Asn Phe Arg Asn Val Val 
                405                 410                 415     


Asp Gly Gln Pro Phe Thr Asn Trp Tyr Asp Asn Gly Ser Asn Gln Val 
            420                 425                 430         


Ala Phe Gly Arg Gly Asn Arg Gly Phe Ile Val Phe Asn Asn Asp Asp 
        435                 440                 445             


Trp Thr Phe Ser Leu Thr Leu Gln Thr Gly Leu Pro Ala Gly Thr Tyr 
    450                 455                 460                 


Cys Asp Val Ile Ser Gly Asp Lys Ile Asn Gly Asn Cys Thr Gly Ile 
465                 470                 475                 480 


Lys Ile Tyr Val Ser Asp Asp Gly Lys Ala His Phe Ser Ile Ser Asn 
                485                 490                 495     


Ser Ala Glu Asp Pro Phe Ile Ala Ile His Ala Glu Ser Lys Leu 
            500                 505                 510     


<210>  791
<211>  370
<212>  PRT
<213>  Homo Sapiens

<400>  791

Met Lys Phe Phe Leu Leu Leu Phe Thr Ile Gly Phe Cys Trp Ala Gln 
1               5                   10                  15      


Tyr Ser Pro Asn Thr Gln Gln Gly Arg Thr Ser Ile Val His Leu Phe 
            20                  25                  30          


Glu Trp Arg Trp Val Asp Ile Ala Leu Glu Cys Glu Arg Tyr Leu Ala 
        35                  40                  45              


Pro Lys Gly Phe Gly Gly Val Gln Val Ser Pro Pro Asn Glu Asn Val 
    50                  55                  60                  


Ala Ile His Asn Pro Phe Arg Pro Trp Trp Glu Arg Tyr Gln Pro Val 
65                  70                  75                  80  


Ser Tyr Lys Leu Cys Thr Arg Ser Gly Asn Glu Asp Glu Phe Arg Asn 
                85                  90                  95      


Met Val Thr Arg Cys Asn Asn Val Gly Val Arg Ile Tyr Val Asp Ala 
            100                 105                 110         


Val Ile Asn His Met Ser Gly Asn Ala Val Ser Ala Gly Thr Ser Ser 
        115                 120                 125             


Thr Cys Gly Ser Tyr Phe Asn Pro Gly Ser Arg Asp Phe Pro Ala Val 
    130                 135                 140                 


Pro Tyr Ser Gly Trp Asp Phe Asn Asp Gly Lys Cys Lys Thr Gly Ser 
145                 150                 155                 160 


Gly Asp Ile Glu Asn Tyr Asn Asp Ala Thr Gln Val Arg Asp Cys Arg 
                165                 170                 175     


Leu Val Gly Leu Leu Asp Leu Ala Leu Glu Lys Asp Tyr Val Arg Ser 
            180                 185                 190         


Lys Ile Ala Glu Tyr Met Asn His Leu Ile Asp Ile Gly Val Ala Gly 
        195                 200                 205             


Phe Arg Leu Asp Ala Ser Lys His Met Trp Pro Gly Asp Ile Lys Ala 
    210                 215                 220                 


Ile Leu Asp Lys Leu His Asn Leu Asn Ser Asn Trp Phe Pro Ala Gly 
225                 230                 235                 240 


Ser Lys Pro Phe Ile Tyr Gln Glu Val Ile Asp Leu Gly Gly Glu Pro 
                245                 250                 255     


Ile Lys Ser Ser Asp Tyr Phe Gly Asn Gly Arg Val Thr Glu Phe Lys 
            260                 265                 270         


Tyr Gly Ala Lys Leu Gly Thr Val Ile Arg Lys Trp Asn Gly Glu Lys 
        275                 280                 285             


Met Ser Tyr Leu Lys Asn Trp Gly Glu Gly Trp Gly Phe Met Pro Ser 
    290                 295                 300                 


Asp Arg Ala Leu Val Phe Val Asp Asn His Asp Asn Gln Arg Gly His 
305                 310                 315                 320 


Gly Ala Gly Gly Ala Ser Ile Leu Thr Phe Trp Asp Ala Arg Leu Tyr 
                325                 330                 335     


Lys Met Ala Val Gly Phe Met Leu Ala His Pro Tyr Gly Phe Thr Arg 
            340                 345                 350         


Val Met Ser Ser Tyr Arg Trp Pro Arg Gln Phe Gln Asn Gly Asn Glu 
        355                 360                 365             


His Gly 
    370 


<210>  792
<211>  511
<212>  PRT
<213>  Homo Sapiens

<400>  792

Met Lys Phe Phe Leu Leu Leu Phe Thr Ile Gly Phe Cys Trp Ala Gln 
1               5                   10                  15      


Tyr Ser Pro Asn Thr Gln Gln Gly Arg Thr Ser Ile Val His Leu Phe 
            20                  25                  30          


Glu Trp Arg Trp Val Asp Ile Ala Leu Glu Cys Glu Arg Tyr Leu Ala 
        35                  40                  45              


Pro Lys Gly Phe Gly Gly Val Gln Val Ser Pro Pro Asn Glu Asn Val 
    50                  55                  60                  


Ala Ile His Asn Pro Phe Arg Pro Trp Trp Glu Arg Tyr Gln Pro Val 
65                  70                  75                  80  


Ser Tyr Lys Leu Cys Thr Arg Ser Gly Asn Glu Asp Glu Phe Arg Asn 
                85                  90                  95      


Met Val Thr Arg Cys Asn Asn Val Gly Val Arg Ile Tyr Val Asp Ala 
            100                 105                 110         


Val Ile Asn His Met Ser Gly Asn Ala Val Ser Ala Gly Thr Ser Ser 
        115                 120                 125             


Thr Cys Gly Ser Tyr Phe Asn Pro Gly Ser Arg Asp Phe Pro Ala Val 
    130                 135                 140                 


Pro Tyr Ser Gly Trp Asp Phe Asn Asp Gly Lys Cys Lys Thr Gly Ser 
145                 150                 155                 160 


Gly Asp Ile Glu Asn Tyr Asn Asp Ala Thr Gln Val Arg Asp Cys Arg 
                165                 170                 175     


Leu Val Gly Leu Leu Asp Leu Ala Leu Glu Lys Asp Tyr Val Arg Ser 
            180                 185                 190         


Lys Ile Ala Glu Tyr Met Asn His Leu Ile Asp Ile Gly Val Ala Gly 
        195                 200                 205             


Phe Arg Leu Asp Ala Ser Lys His Met Trp Pro Gly Asp Ile Lys Ala 
    210                 215                 220                 


Ile Leu Asp Lys Leu His Asn Leu Asn Ser Asn Trp Phe Pro Ala Gly 
225                 230                 235                 240 


Ser Lys Pro Phe Ile Tyr Gln Glu Val Ile Asp Leu Gly Gly Glu Pro 
                245                 250                 255     


Ile Lys Ser Ser Asp Tyr Phe Gly Asn Gly Arg Val Thr Glu Phe Lys 
            260                 265                 270         


Tyr Gly Ala Lys Leu Gly Thr Val Ile Arg Lys Trp Asn Gly Glu Lys 
        275                 280                 285             


Met Ser Tyr Leu Lys Asn Trp Gly Glu Gly Trp Gly Phe Met Pro Ser 
    290                 295                 300                 


Asp Arg Ala Leu Val Phe Val Asp Asn His Asp Asn Gln Arg Gly His 
305                 310                 315                 320 


Gly Ala Gly Gly Ala Ser Ile Leu Thr Phe Trp Asp Ala Arg Leu Tyr 
                325                 330                 335     


Lys Met Ala Val Gly Phe Met Leu Ala His Pro Tyr Gly Phe Thr Arg 
            340                 345                 350         


Val Met Ser Ser Tyr Arg Trp Pro Arg Gln Phe Gln Asn Gly Asn Asp 
        355                 360                 365             


Val Asn Asp Trp Val Gly Pro Pro Asn Asn Asn Gly Val Ile Lys Glu 
    370                 375                 380                 


Val Thr Ile Asn Pro Asp Thr Thr Cys Gly Asn Asp Trp Val Cys Glu 
385                 390                 395                 400 


His Arg Trp Arg Gln Ile Arg Asn Met Val Asn Phe Arg Asn Val Val 
                405                 410                 415     


Asp Gly Gln Pro Phe Thr Asn Trp Tyr Asp Asn Gly Ser Asn Gln Val 
            420                 425                 430         


Ala Phe Gly Arg Gly Asn Arg Gly Phe Ile Val Phe Asn Asn Asp Asp 
        435                 440                 445             


Trp Thr Phe Ser Leu Thr Leu Gln Thr Gly Leu Pro Ala Gly Thr Tyr 
    450                 455                 460                 


Cys Asp Val Ile Ser Gly Asp Lys Ile Asn Gly Asn Cys Thr Gly Ile 
465                 470                 475                 480 


Lys Ile Tyr Val Ser Asp Asp Gly Lys Ala His Phe Ser Ile Ser Asn 
                485                 490                 495     


Ser Ala Glu Asp Pro Phe Ile Ala Ile His Ala Glu Ser Lys Leu 
            500                 505                 510     


<210>  793
<211>  147
<212>  PRT
<213>  Homo Sapiens

<400>  793

Met Val Met Gly Leu Gly Val Leu Leu Leu Val Phe Val Leu Gly Leu 
1               5                   10                  15      


Gly Leu Thr Pro Pro Thr Leu Ala Gln Asp Asn Ser Arg Tyr Thr His 
            20                  25                  30          


Phe Leu Thr Gln His Tyr Asp Ala Lys Pro Gln Gly Arg Asp Asp Arg 
        35                  40                  45              


Tyr Cys Glu Ser Ile Met Arg Arg Arg Gly Leu Thr Ser Pro Cys Lys 
    50                  55                  60                  


Asp Ile Asn Thr Phe Ile His Gly Asn Lys Arg Ser Ile Lys Ala Ile 
65                  70                  75                  80  


Cys Glu Asn Lys Asn Gly Asn Pro His Arg Glu Asn Leu Arg Ile Ser 
                85                  90                  95      


Lys Ser Ser Phe Gln Val Thr Thr Cys Lys Leu His Gly Gly Ser Pro 
            100                 105                 110         


Trp Pro Pro Cys Gln Tyr Arg Ala Thr Ala Gly Phe Arg Asn Val Val 
        115                 120                 125             


Val Ala Cys Glu Asn Gly Leu Pro Val His Leu Asp Gln Ser Ile Phe 
    130                 135                 140                 


Arg Arg Pro 
145         


<210>  794
<211>  147
<212>  PRT
<213>  Homo Sapiens

<400>  794

Met Val Met Gly Leu Gly Val Leu Leu Leu Val Phe Val Leu Gly Leu 
1               5                   10                  15      


Gly Leu Thr Pro Pro Thr Leu Ala Gln Asp Asn Ser Arg Tyr Thr His 
            20                  25                  30          


Phe Leu Thr Gln His Tyr Asp Ala Lys Pro Gln Gly Arg Asp Asp Arg 
        35                  40                  45              


Tyr Cys Glu Ser Ile Met Arg Arg Arg Gly Leu Thr Ser Pro Cys Lys 
    50                  55                  60                  


Asp Ile Asn Thr Phe Ile His Gly Asn Lys Arg Ser Ile Lys Ala Ile 
65                  70                  75                  80  


Cys Glu Asn Lys Asn Gly Asn Pro His Arg Glu Asn Leu Arg Ile Ser 
                85                  90                  95      


Lys Ser Ser Phe Gln Val Thr Thr Cys Lys Leu His Gly Gly Ser Pro 
            100                 105                 110         


Trp Pro Pro Cys Gln Tyr Arg Ala Thr Ala Gly Phe Arg Asn Val Val 
        115                 120                 125             


Val Ala Cys Glu Asn Gly Leu Pro Val His Leu Asp Gln Ser Ile Phe 
    130                 135                 140                 


Arg Arg Pro 
145         


<210>  795
<211>  129
<212>  PRT
<213>  Homo Sapiens

<400>  795

Met Ala Pro Arg Gly Pro Glu Gln Glu Glu Cys Glu Gly Leu Leu Gln 
1               5                   10                  15      


Gln Trp Arg Glu Glu Gly Leu Ser Gln Val Leu Ser Thr Ala Ser Glu 
            20                  25                  30          


Gly Pro Leu Ile Asp Lys Gly Leu Ala Gln Ser Ser Leu Ala Leu Leu 
        35                  40                  45              


Met Asp Asn Pro Gly Glu Glu Asn Ala Ala Ser Glu Asp Arg Trp Ser 
    50                  55                  60                  


Ser Arg Gln Leu Ser Asp Leu Arg Ala Ala Glu Asn Leu Asp Glu Pro 
65                  70                  75                  80  


Phe Pro Glu Met Leu Gly Glu Glu Pro Leu Leu Glu Val Glu Gly Val 
                85                  90                  95      


Glu Gly Ser Met Trp Ala Ala Ile Pro Met Gln Ser Glu Pro Gln Tyr 
            100                 105                 110         


Ala Asp Cys Ala Ala Leu Pro Val Gly Ala Leu Ala Thr Glu Gln Trp 
        115                 120                 125             


Glu 
    


<210>  796
<211>  67
<212>  PRT
<213>  Homo Sapiens

<400>  796

Met Glu Gly Val Thr Asp Thr Lys Pro Glu Arg Pro Ala Gly Trp Ala 
1               5                   10                  15      


Glu Ser Val Leu Glu Glu Asp Ala Ser Glu Leu Glu Pro Ala Phe Ser 
            20                  25                  30          


Arg Thr Val Gly Thr Ile Gln His Cys Leu His Leu Thr Ser Val Tyr 
        35                  40                  45              


Thr His Phe Leu Pro Gln Arg Gly Arg Pro Glu Val Thr Thr Met Pro 
    50                  55                  60                  


Leu Gly Leu 
65          


<210>  797
<211>  670
<212>  PRT
<213>  Homo Sapiens

<400>  797

Met Ile Ala Ser Cys Leu Cys Tyr Leu Leu Leu Pro Ala Thr Arg Leu 
1               5                   10                  15      


Phe Arg Ala Leu Ser Asp Ala Phe Phe Thr Cys Arg Lys Asn Val Leu 
            20                  25                  30          


Leu Ala Asn Ser Ser Ser Pro Gln Val Glu Gly Asp Phe Ala Met Ala 
        35                  40                  45              


Pro Arg Gly Pro Glu Gln Glu Glu Cys Glu Gly Leu Leu Gln Gln Trp 
    50                  55                  60                  


Arg Glu Glu Gly Leu Ser Gln Val Leu Ser Thr Ala Ser Glu Gly Pro 
65                  70                  75                  80  


Leu Ile Asp Lys Gly Leu Ala Gln Ser Ser Leu Ala Leu Leu Met Asp 
                85                  90                  95      


Asn Pro Gly Glu Glu Asn Ala Ala Ser Glu Asp Arg Trp Ser Ser Arg 
            100                 105                 110         


Gln Leu Ser Asp Leu Arg Ala Ala Glu Asn Leu Asp Glu Pro Phe Pro 
        115                 120                 125             


Glu Met Leu Gly Glu Glu Pro Leu Leu Glu Val Glu Gly Val Glu Gly 
    130                 135                 140                 


Ser Met Trp Ala Ala Ile Pro Met Gln Ser Glu Pro Gln Tyr Ala Asp 
145                 150                 155                 160 


Cys Ala Ala Leu Pro Val Gly Ala Leu Ala Thr Glu Gln Trp Glu Glu 
                165                 170                 175     


Asp Pro Ala Val Leu Ala Trp Ser Ile Ala Pro Glu Pro Val Pro Gln 
            180                 185                 190         


Glu Glu Ala Ser Ile Trp Pro Phe Glu Gly Leu Gly Gln Leu Gln Pro 
        195                 200                 205             


Pro Ala Val Glu Ile Pro Tyr His Glu Ile Leu Trp Arg Glu Trp Glu 
    210                 215                 220                 


Asp Phe Ser Thr Gln Pro Asp Ala Gln Gly Leu Lys Ala Gly Asp Gly 
225                 230                 235                 240 


Pro Gln Phe Gln Phe Thr Leu Met Ser Tyr Asn Ile Leu Ala Gln Asp 
                245                 250                 255     


Leu Met Gln Gln Ser Ser Glu Leu Tyr Leu His Cys His Pro Asp Ile 
            260                 265                 270         


Leu Asn Trp Asn Tyr Arg Phe Val Asn Leu Met Gln Glu Phe Gln His 
        275                 280                 285             


Trp Asp Pro Asp Ile Leu Cys Leu Gln Glu Val Gln Glu Asp His Tyr 
    290                 295                 300                 


Trp Glu Gln Leu Glu Pro Ser Leu Arg Met Met Gly Phe Thr Cys Phe 
305                 310                 315                 320 


Tyr Lys Arg Arg Thr Gly Cys Lys Thr Asp Gly Cys Ala Val Cys Tyr 
                325                 330                 335     


Lys Pro Thr Arg Phe Arg Leu Leu Cys Ala Ser Pro Val Glu Tyr Phe 
            340                 345                 350         


Arg Pro Gly Leu Glu Leu Leu Asn Arg Asp Asn Val Gly Leu Val Leu 
        355                 360                 365             


Leu Leu Gln Pro Leu Val Pro Glu Gly Leu Gly Gln Val Ser Val Ala 
    370                 375                 380                 


Pro Leu Cys Val Ala Asn Thr His Ile Leu Tyr Asn Pro Arg Arg Gly 
385                 390                 395                 400 


Asp Val Lys Leu Ala Gln Met Ala Ile Leu Leu Ala Glu Val Asp Lys 
                405                 410                 415     


Val Ala Arg Leu Ser Asp Gly Ser His Cys Pro Ile Ile Leu Cys Gly 
            420                 425                 430         


Asp Leu Asn Ser Val Pro Asp Ser Pro Leu Tyr Asn Phe Ile Arg Asp 
        435                 440                 445             


Gly Glu Leu Gln Tyr His Gly Met Pro Ala Trp Lys Val Ser Gly Gln 
    450                 455                 460                 


Glu Asp Phe Ser His Gln Leu Tyr Gln Arg Lys Leu Gln Ala Pro Leu 
465                 470                 475                 480 


Trp Pro Ser Ser Leu Gly Ile Thr Asp Cys Cys Gln Tyr Val Thr Ser 
                485                 490                 495     


Cys His Pro Lys Arg Ser Glu Arg Arg Lys Tyr Gly Arg Asp Phe Leu 
            500                 505                 510         


Leu Arg Phe Arg Phe Cys Ser Ile Ala Cys Gln Arg Pro Val Gly Leu 
        515                 520                 525             


Val Leu Met Glu Gly Val Thr Asp Thr Lys Pro Glu Arg Pro Ala Gly 
    530                 535                 540                 


Trp Ala Glu Ser Val Leu Glu Glu Asp Ala Ser Glu Leu Glu Pro Ala 
545                 550                 555                 560 


Phe Ser Arg Thr Val Gly Thr Ile Gln His Cys Leu His Leu Thr Ser 
                565                 570                 575     


Val Tyr Thr His Phe Leu Pro Gln Arg Gly Arg Pro Glu Val Thr Thr 
            580                 585                 590         


Met Pro Leu Gly Leu Gly Met Thr Val Asp Tyr Ile Phe Phe Ser Ala 
        595                 600                 605             


Glu Ser Cys Glu Asn Gly Asn Arg Thr Asp His Arg Leu Tyr Arg Asp 
    610                 615                 620                 


Gly Thr Leu Lys Leu Leu Gly Arg Leu Ser Leu Leu Ser Glu Glu Ile 
625                 630                 635                 640 


Leu Trp Ala Ala Asn Gly Leu Pro Asn Pro Phe Cys Ser Ser Asp His 
                645                 650                 655     


Leu Cys Leu Leu Ala Ser Phe Gly Met Glu Val Thr Ala Pro 
            660                 665                 670 


<210>  798
<211>  235
<212>  PRT
<213>  Homo Sapiens

<400>  798

Met Ser Gln Asn Met Gly Cys Tyr Phe Leu Phe Leu Ser Trp Phe Pro 
1               5                   10                  15      


Tyr Ser His Pro Ser Phe Ser Thr Gln Val Ser Gly Gln Glu Asp Phe 
            20                  25                  30          


Ser His Gln Leu Tyr Gln Arg Lys Leu Gln Ala Pro Leu Trp Pro Ser 
        35                  40                  45              


Ser Leu Gly Ile Thr Asp Cys Cys Gln Tyr Val Thr Ser Cys His Pro 
    50                  55                  60                  


Lys Arg Ser Glu Arg Arg Lys Tyr Gly Arg Asp Phe Leu Leu Arg Phe 
65                  70                  75                  80  


Arg Phe Cys Ser Ile Ala Cys Gln Arg Pro Val Gly Leu Val Leu Met 
                85                  90                  95      


Glu Gly Val Thr Asp Thr Lys Pro Glu Arg Pro Ala Gly Trp Ala Glu 
            100                 105                 110         


Ser Val Leu Glu Glu Asp Ala Ser Glu Leu Glu Pro Ala Phe Ser Arg 
        115                 120                 125             


Thr Val Gly Thr Ile Gln His Cys Leu His Leu Thr Ser Val Tyr Thr 
    130                 135                 140                 


His Phe Leu Pro Gln Arg Gly Arg Pro Glu Val Thr Thr Met Pro Leu 
145                 150                 155                 160 


Gly Leu Gly Met Thr Val Asp Tyr Ile Phe Phe Ser Ala Glu Ser Cys 
                165                 170                 175     


Glu Asn Gly Asn Arg Thr Asp His Arg Leu Tyr Arg Asp Gly Thr Leu 
            180                 185                 190         


Lys Leu Leu Gly Arg Leu Ser Leu Leu Ser Glu Glu Ile Leu Trp Ala 
        195                 200                 205             


Ala Asn Gly Leu Pro Asn Pro Phe Cys Ser Ser Asp His Leu Cys Leu 
    210                 215                 220                 


Leu Ala Ser Phe Gly Met Glu Val Thr Ala Pro 
225                 230                 235 


<210>  799
<211>  298
<212>  PRT
<213>  Homo Sapiens

<400>  799

Met Glu Gly Lys His Lys Glu Glu Leu Asp Thr Leu Lys Glu Glu Lys 
1               5                   10                  15      


Glu Asn Leu Gln Gly Leu Val Thr Arg Gln Thr Tyr Ile Ile Gln Glu 
            20                  25                  30          


Leu Glu Lys Gln Leu Asn Arg Ala Thr Thr Asn Asn Ser Val Leu Gln 
        35                  40                  45              


Lys Gln Gln Leu Glu Leu Met Asp Thr Val His Asn Leu Val Asn Leu 
    50                  55                  60                  


Cys Thr Lys Glu Gly Val Leu Leu Lys Gly Gly Lys Arg Glu Glu Glu 
65                  70                  75                  80  


Lys Pro Phe Arg Asp Cys Ala Asp Val Tyr Gln Ala Gly Phe Asn Lys 
                85                  90                  95      


Ser Gly Ile Tyr Thr Ile Tyr Ile Asn Asn Met Pro Glu Pro Lys Lys 
            100                 105                 110         


Val Phe Cys Asn Met Asp Val Asn Gly Gly Gly Trp Thr Val Ile Gln 
        115                 120                 125             


His Arg Glu Asp Gly Ser Leu Asp Phe Gln Arg Gly Trp Lys Glu Tyr 
    130                 135                 140                 


Lys Met Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu 
145                 150                 155                 160 


Phe Ile Phe Ala Ile Thr Ser Gln Arg Gln Tyr Met Leu Arg Ile Glu 
                165                 170                 175     


Leu Met Asp Trp Glu Gly Asn Arg Ala Tyr Ser Gln Tyr Asp Arg Phe 
            180                 185                 190         


His Ile Gly Asn Glu Lys Gln Asn Tyr Arg Leu Tyr Leu Lys Gly His 
        195                 200                 205             


Thr Gly Thr Ala Gly Lys Gln Ser Ser Leu Ile Leu His Gly Ala Asp 
    210                 215                 220                 


Phe Ser Thr Lys Asp Ala Asp Asn Asp Asn Cys Met Cys Lys Cys Ala 
225                 230                 235                 240 


Leu Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn 
                245                 250                 255     


Leu Asn Gly Met Phe Tyr Thr Ala Gly Gln Asn His Gly Lys Leu Asn 
            260                 265                 270         


Gly Ile Lys Trp His Tyr Phe Lys Gly Pro Ser Tyr Ser Leu Arg Ser 
        275                 280                 285             


Thr Thr Met Met Ile Arg Pro Leu Asp Phe 
    290                 295             


<210>  800
<211>  297
<212>  PRT
<213>  Homo Sapiens

<400>  800

Met Glu Gly Lys His Lys Glu Glu Leu Asp Thr Leu Lys Glu Glu Lys 
1               5                   10                  15      


Glu Asn Leu Gln Gly Leu Val Thr Arg Gln Thr Tyr Ile Ile Gln Glu 
            20                  25                  30          


Leu Glu Lys Gln Leu Asn Arg Ala Thr Thr Asn Asn Ser Val Leu Gln 
        35                  40                  45              


Lys Gln Gln Leu Glu Leu Met Asp Thr Val His Asn Leu Val Asn Leu 
    50                  55                  60                  


Cys Thr Lys Glu Val Leu Leu Lys Gly Gly Lys Arg Glu Glu Glu Lys 
65                  70                  75                  80  


Pro Phe Arg Asp Cys Ala Asp Val Tyr Gln Ala Gly Phe Asn Lys Ser 
                85                  90                  95      


Gly Ile Tyr Thr Ile Tyr Ile Asn Asn Met Pro Glu Pro Lys Lys Val 
            100                 105                 110         


Phe Cys Asn Met Asp Val Asn Gly Gly Gly Trp Thr Val Ile Gln His 
        115                 120                 125             


Arg Glu Asp Gly Ser Leu Asp Phe Gln Arg Gly Trp Lys Glu Tyr Lys 
    130                 135                 140                 


Met Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu Phe 
145                 150                 155                 160 


Ile Phe Ala Ile Thr Ser Gln Arg Gln Tyr Met Leu Arg Ile Glu Leu 
                165                 170                 175     


Met Asp Trp Glu Gly Asn Arg Ala Tyr Ser Gln Tyr Asp Arg Phe His 
            180                 185                 190         


Ile Gly Asn Glu Lys Gln Asn Tyr Arg Leu Tyr Leu Lys Gly His Thr 
        195                 200                 205             


Gly Thr Ala Gly Lys Gln Ser Ser Leu Ile Leu His Gly Ala Asp Phe 
    210                 215                 220                 


Ser Thr Lys Asp Ala Asp Asn Asp Asn Cys Met Cys Lys Cys Ala Leu 
225                 230                 235                 240 


Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn Leu 
                245                 250                 255     


Asn Gly Met Phe Tyr Thr Ala Gly Gln Asn His Gly Lys Leu Asn Gly 
            260                 265                 270         


Ile Lys Trp His Tyr Phe Lys Gly Pro Ser Tyr Ser Leu Arg Ser Thr 
        275                 280                 285             


Thr Met Met Ile Arg Pro Leu Asp Phe 
    290                 295         


<210>  801
<211>  30
<212>  PRT
<213>  Homo Sapiens

<400>  801

Met Lys Ser Glu Met Ala Gln Ile Gln Gln Asn Ala Val Gln Asn His 
1               5                   10                  15      


Thr Ala Thr Met Leu Glu Ile Gly Thr Ser Leu Leu Ser Gln 
            20                  25                  30  


<210>  802
<211>  497
<212>  PRT
<213>  Homo Sapiens

<400>  802

Met Thr Val Phe Leu Ser Phe Ala Phe Leu Ala Ala Ile Leu Thr His 
1               5                   10                  15      


Ile Gly Cys Ser Asn Gln Arg Arg Ser Pro Glu Asn Ser Gly Arg Arg 
            20                  25                  30          


Tyr Asn Arg Ile Gln His Gly Gln Cys Ala Tyr Thr Phe Ile Leu Pro 
        35                  40                  45              


Glu His Asp Gly Asn Cys Arg Glu Ser Thr Thr Asp Gln Tyr Asn Thr 
    50                  55                  60                  


Asn Ala Leu Gln Arg Asp Ala Pro His Val Glu Pro Asp Phe Ser Ser 
65                  70                  75                  80  


Gln Lys Leu Gln His Leu Glu His Val Met Glu Asn Tyr Thr Gln Trp 
                85                  90                  95      


Leu Gln Lys Leu Glu Asn Tyr Ile Val Glu Asn Met Lys Ser Glu Met 
            100                 105                 110         


Ala Gln Ile Gln Gln Asn Ala Val Gln Asn His Thr Ala Thr Met Leu 
        115                 120                 125             


Glu Ile Gly Thr Ser Leu Leu Ser Gln Thr Ala Glu Gln Thr Arg Lys 
    130                 135                 140                 


Leu Thr Asp Val Glu Thr Gln Val Leu Asn Gln Thr Ser Arg Leu Glu 
145                 150                 155                 160 


Ile Gln Leu Leu Glu Asn Ser Leu Ser Thr Tyr Lys Leu Glu Lys Gln 
                165                 170                 175     


Leu Leu Gln Gln Thr Asn Glu Ile Leu Lys Ile His Glu Lys Asn Ser 
            180                 185                 190         


Leu Leu Glu His Lys Ile Leu Glu Met Glu Gly Lys His Lys Glu Glu 
        195                 200                 205             


Leu Asp Thr Leu Lys Glu Glu Lys Glu Asn Leu Gln Gly Leu Val Thr 
    210                 215                 220                 


Arg Gln Thr Tyr Ile Ile Gln Glu Leu Glu Lys Gln Leu Asn Arg Ala 
225                 230                 235                 240 


Thr Thr Asn Asn Ser Val Leu Gln Lys Gln Gln Leu Glu Leu Met Asp 
                245                 250                 255     


Thr Val His Asn Leu Val Asn Leu Cys Thr Lys Glu Val Leu Leu Lys 
            260                 265                 270         


Gly Gly Lys Arg Glu Glu Glu Lys Pro Phe Arg Asp Cys Ala Asp Val 
        275                 280                 285             


Tyr Gln Ala Gly Phe Asn Lys Ser Gly Ile Tyr Thr Ile Tyr Ile Asn 
    290                 295                 300                 


Asn Met Pro Glu Pro Lys Lys Val Phe Cys Asn Met Asp Val Asn Gly 
305                 310                 315                 320 


Gly Gly Trp Thr Val Ile Gln His Arg Glu Asp Gly Ser Leu Asp Phe 
                325                 330                 335     


Gln Arg Gly Trp Lys Glu Tyr Lys Met Gly Phe Gly Asn Pro Ser Gly 
            340                 345                 350         


Glu Tyr Trp Leu Gly Asn Glu Phe Ile Phe Ala Ile Thr Ser Gln Arg 
        355                 360                 365             


Gln Tyr Met Leu Arg Ile Glu Leu Met Asp Trp Glu Gly Asn Arg Ala 
    370                 375                 380                 


Tyr Ser Gln Tyr Asp Arg Phe His Ile Gly Asn Glu Lys Gln Asn Tyr 
385                 390                 395                 400 


Arg Leu Tyr Leu Lys Gly His Thr Gly Thr Ala Gly Lys Gln Ser Ser 
                405                 410                 415     


Leu Ile Leu His Gly Ala Asp Phe Ser Thr Lys Asp Ala Asp Asn Asp 
            420                 425                 430         


Asn Cys Met Cys Lys Cys Ala Leu Met Leu Thr Gly Gly Trp Trp Phe 
        435                 440                 445             


Asp Ala Cys Gly Pro Ser Asn Leu Asn Gly Met Phe Tyr Thr Ala Gly 
    450                 455                 460                 


Gln Asn His Gly Lys Leu Asn Gly Ile Lys Trp His Tyr Phe Lys Gly 
465                 470                 475                 480 


Pro Ser Tyr Ser Leu Arg Ser Thr Thr Met Met Ile Arg Pro Leu Asp 
                485                 490                 495     


Phe 
    


<210>  803
<211>  498
<212>  PRT
<213>  Homo Sapiens

<400>  803

Met Thr Val Phe Leu Ser Phe Ala Phe Leu Ala Ala Ile Leu Thr His 
1               5                   10                  15      


Ile Gly Cys Ser Asn Gln Arg Arg Ser Pro Glu Asn Ser Gly Arg Arg 
            20                  25                  30          


Tyr Asn Arg Ile Gln His Gly Gln Cys Ala Tyr Thr Phe Ile Leu Pro 
        35                  40                  45              


Glu His Asp Gly Asn Cys Arg Glu Ser Thr Thr Asp Gln Tyr Asn Thr 
    50                  55                  60                  


Asn Ala Leu Gln Arg Asp Ala Pro His Val Glu Pro Asp Phe Ser Ser 
65                  70                  75                  80  


Gln Lys Leu Gln His Leu Glu His Val Met Glu Asn Tyr Thr Gln Trp 
                85                  90                  95      


Leu Gln Lys Leu Glu Asn Tyr Ile Val Glu Asn Met Lys Ser Glu Met 
            100                 105                 110         


Ala Gln Ile Gln Gln Asn Ala Val Gln Asn His Thr Ala Thr Met Leu 
        115                 120                 125             


Glu Ile Gly Thr Ser Leu Leu Ser Gln Thr Ala Glu Gln Thr Arg Lys 
    130                 135                 140                 


Leu Thr Asp Val Glu Thr Gln Val Leu Asn Gln Thr Ser Arg Leu Glu 
145                 150                 155                 160 


Ile Gln Leu Leu Glu Asn Ser Leu Ser Thr Tyr Lys Leu Glu Lys Gln 
                165                 170                 175     


Leu Leu Gln Gln Thr Asn Glu Ile Leu Lys Ile His Glu Lys Asn Ser 
            180                 185                 190         


Leu Leu Glu His Lys Ile Leu Glu Met Glu Gly Lys His Lys Glu Glu 
        195                 200                 205             


Leu Asp Thr Leu Lys Glu Glu Lys Glu Asn Leu Gln Gly Leu Val Thr 
    210                 215                 220                 


Arg Gln Thr Tyr Ile Ile Gln Glu Leu Glu Lys Gln Leu Asn Arg Ala 
225                 230                 235                 240 


Thr Thr Asn Asn Ser Val Leu Gln Lys Gln Gln Leu Glu Leu Met Asp 
                245                 250                 255     


Thr Val His Asn Leu Val Asn Leu Cys Thr Lys Glu Gly Val Leu Leu 
            260                 265                 270         


Lys Gly Gly Lys Arg Glu Glu Glu Lys Pro Phe Arg Asp Cys Ala Asp 
        275                 280                 285             


Val Tyr Gln Ala Gly Phe Asn Lys Ser Gly Ile Tyr Thr Ile Tyr Ile 
    290                 295                 300                 


Asn Asn Met Pro Glu Pro Lys Lys Val Phe Cys Asn Met Asp Val Asn 
305                 310                 315                 320 


Gly Gly Gly Trp Thr Val Ile Gln His Arg Glu Asp Gly Ser Leu Asp 
                325                 330                 335     


Phe Gln Arg Gly Trp Lys Glu Tyr Lys Met Gly Phe Gly Asn Pro Ser 
            340                 345                 350         


Gly Glu Tyr Trp Leu Gly Asn Glu Phe Ile Phe Ala Ile Thr Ser Gln 
        355                 360                 365             


Arg Gln Tyr Met Leu Arg Ile Glu Leu Met Asp Trp Glu Gly Asn Arg 
    370                 375                 380                 


Ala Tyr Ser Gln Tyr Asp Arg Phe His Ile Gly Asn Glu Lys Gln Asn 
385                 390                 395                 400 


Tyr Arg Leu Tyr Leu Lys Gly His Thr Gly Thr Ala Gly Lys Gln Ser 
                405                 410                 415     


Ser Leu Ile Leu His Gly Ala Asp Phe Ser Thr Lys Asp Ala Asp Asn 
            420                 425                 430         


Asp Asn Cys Met Cys Lys Cys Ala Leu Met Leu Thr Gly Gly Trp Trp 
        435                 440                 445             


Phe Asp Ala Cys Gly Pro Ser Asn Leu Asn Gly Met Phe Tyr Thr Ala 
    450                 455                 460                 


Gly Gln Asn His Gly Lys Leu Asn Gly Ile Lys Trp His Tyr Phe Lys 
465                 470                 475                 480 


Gly Pro Ser Tyr Ser Leu Arg Ser Thr Thr Met Met Ile Arg Pro Leu 
                485                 490                 495     


Asp Phe 
        


<210>  804
<211>  496
<212>  PRT
<213>  Homo Sapiens

<400>  804

Met Trp Gln Ile Val Phe Phe Thr Leu Ser Cys Asp Leu Val Leu Ala 
1               5                   10                  15      


Ala Ala Tyr Asn Asn Phe Arg Lys Ser Met Asp Ser Ile Gly Lys Lys 
            20                  25                  30          


Gln Tyr Gln Val Gln His Gly Ser Cys Ser Tyr Thr Phe Leu Leu Pro 
        35                  40                  45              


Glu Met Asp Asn Cys Arg Ser Ser Ser Ser Pro Tyr Val Ser Asn Ala 
    50                  55                  60                  


Val Gln Arg Asp Ala Pro Leu Glu Tyr Asp Asp Ser Val Gln Arg Leu 
65                  70                  75                  80  


Gln Val Leu Glu Asn Ile Met Glu Asn Asn Thr Gln Trp Leu Met Lys 
                85                  90                  95      


Leu Glu Asn Tyr Ile Gln Asp Asn Met Lys Lys Glu Met Val Glu Ile 
            100                 105                 110         


Gln Gln Asn Ala Val Gln Asn Gln Thr Ala Val Met Ile Glu Ile Gly 
        115                 120                 125             


Thr Asn Leu Leu Asn Gln Thr Ala Glu Gln Thr Arg Lys Leu Thr Asp 
    130                 135                 140                 


Val Glu Ala Gln Val Leu Asn Gln Thr Thr Arg Leu Glu Leu Gln Leu 
145                 150                 155                 160 


Leu Glu His Ser Leu Ser Thr Asn Lys Leu Glu Lys Gln Ile Leu Asp 
                165                 170                 175     


Gln Thr Ser Glu Ile Asn Lys Leu Gln Asp Lys Asn Ser Phe Leu Glu 
            180                 185                 190         


Lys Lys Val Leu Ala Met Glu Asp Lys His Ile Ile Gln Leu Gln Ser 
        195                 200                 205             


Ile Lys Glu Glu Lys Asp Gln Leu Gln Val Leu Val Ser Lys Gln Asn 
    210                 215                 220                 


Ser Ile Ile Glu Glu Leu Glu Lys Lys Ile Val Thr Ala Thr Val Asn 
225                 230                 235                 240 


Asn Ser Val Leu Gln Lys Gln Gln His Asp Leu Met Glu Thr Val Asn 
                245                 250                 255     


Asn Leu Leu Thr Met Met Ser Thr Ser Asn Ser Ala Lys Asp Pro Thr 
            260                 265                 270         


Val Ala Lys Glu Glu Gln Ile Ser Phe Arg Asp Cys Ala Glu Val Phe 
        275                 280                 285             


Lys Ser Gly His Thr Thr Asn Gly Ile Tyr Thr Leu Thr Phe Pro Asn 
    290                 295                 300                 


Ser Thr Glu Glu Ile Lys Ala Tyr Cys Asp Met Glu Ala Gly Gly Gly 
305                 310                 315                 320 


Gly Trp Thr Ile Ile Gln Arg Arg Glu Asp Gly Ser Val Asp Phe Gln 
                325                 330                 335     


Arg Thr Trp Lys Glu Tyr Lys Val Gly Phe Gly Asn Pro Ser Gly Glu 
            340                 345                 350         


Tyr Trp Leu Gly Asn Glu Phe Val Ser Gln Leu Thr Asn Gln Gln Arg 
        355                 360                 365             


Tyr Val Leu Lys Ile His Leu Lys Asp Trp Glu Gly Asn Glu Ala Tyr 
    370                 375                 380                 


Ser Leu Tyr Glu His Phe Tyr Leu Ser Ser Glu Glu Leu Asn Tyr Arg 
385                 390                 395                 400 


Ile His Leu Lys Gly Leu Thr Gly Thr Ala Gly Lys Ile Ser Ser Ile 
                405                 410                 415     


Ser Gln Pro Gly Asn Asp Phe Ser Thr Lys Asp Gly Asp Asn Asp Lys 
            420                 425                 430         


Cys Ile Cys Lys Cys Ser Gln Met Leu Thr Gly Gly Trp Trp Phe Asp 
        435                 440                 445             


Ala Cys Gly Pro Ser Asn Leu Asn Gly Met Tyr Tyr Pro Gln Arg Gln 
    450                 455                 460                 


Asn Thr Asn Lys Phe Asn Gly Ile Lys Trp Tyr Tyr Trp Lys Gly Ser 
465                 470                 475                 480 


Gly Tyr Ser Leu Lys Ala Thr Thr Met Met Ile Arg Pro Ala Asp Phe 
                485                 490                 495     


<210>  805
<211>  459
<212>  PRT
<213>  Homo Sapiens

<400>  805

Met Trp Gln Ile Val Phe Phe Thr Leu Ser Cys Asp Leu Val Leu Ala 
1               5                   10                  15      


Ala Ala Tyr Asn Asn Phe Arg Lys Ser Met Asp Ser Ile Gly Lys Lys 
            20                  25                  30          


Gln Tyr Gln Val Gln His Gly Ser Cys Ser Tyr Thr Phe Leu Leu Pro 
        35                  40                  45              


Glu Met Asp Asn Cys Arg Ser Ser Ser Ser Pro Tyr Val Ser Asn Ala 
    50                  55                  60                  


Val Gln Arg Asp Ala Pro Leu Glu Tyr Asp Asp Ser Val Gln Arg Leu 
65                  70                  75                  80  


Gln Val Leu Glu Asn Ile Met Glu Asn Asn Thr Gln Trp Leu Met Lys 
                85                  90                  95      


Leu Glu Asn Tyr Ile Gln Asp Asn Met Lys Lys Glu Met Val Glu Ile 
            100                 105                 110         


Gln Gln Asn Ala Val Gln Asn Gln Thr Ala Val Met Ile Glu Ile Gly 
        115                 120                 125             


Thr Asn Leu Leu Asn Gln Thr Ala Glu Gln Thr Arg Lys Leu Thr Asp 
    130                 135                 140                 


Val Glu Ala Gln Val Leu Asn Gln Thr Thr Arg Leu Glu Leu Gln Leu 
145                 150                 155                 160 


Leu Glu His Ser Leu Ser Thr Asn Lys Leu Glu Lys Gln Ile Leu Asp 
                165                 170                 175     


Gln Thr Ser Glu Ile Asn Lys Leu Gln Asp Lys Asn Ser Phe Leu Glu 
            180                 185                 190         


Lys Lys Val Leu Ala Met Glu Asp Lys His Ile Ile Gln Leu Gln Ser 
        195                 200                 205             


Ile Lys Glu Glu Lys Asp Gln Leu Gln Val Leu Val Ser Lys Gln Asn 
    210                 215                 220                 


Ser Ile Ile Glu Glu Leu Glu Lys Lys Ile Val Thr Ala Thr Val Asn 
225                 230                 235                 240 


Asn Ser Val Leu Gln Lys Gln Gln His Asp Leu Met Glu Thr Val Asn 
                245                 250                 255     


Asn Leu Leu Thr Met Met Ser Thr Ser Asn Ser Lys Asp Pro Thr Val 
            260                 265                 270         


Ala Lys Glu Glu Gln Ile Ser Phe Arg Asp Cys Ala Glu Val Phe Lys 
        275                 280                 285             


Ser Gly His Thr Thr Asn Gly Ile Tyr Thr Leu Thr Phe Pro Asn Ser 
    290                 295                 300                 


Thr Glu Glu Ile Lys Ala Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly 
305                 310                 315                 320 


Trp Thr Ile Ile Gln Arg Arg Glu Asp Gly Ser Val Asp Phe Gln Arg 
                325                 330                 335     


Thr Trp Lys Glu Tyr Lys Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr 
            340                 345                 350         


Trp Leu Gly Asn Glu Phe Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr 
        355                 360                 365             


Val Leu Lys Ile His Leu Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser 
    370                 375                 380                 


Leu Tyr Glu His Phe Tyr Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile 
385                 390                 395                 400 


His Leu Lys Gly Leu Thr Gly Thr Ala Gly Lys Ile Ser Ser Ile Ser 
                405                 410                 415     


Gln Pro Gly Asn Asp Phe Ser Thr Lys Asp Gly Asp Asn Asp Lys Cys 
            420                 425                 430         


Ile Cys Lys Cys Ser Gln Met Leu Thr Gly Gly Arg Asp Asp Phe Leu 
        435                 440                 445             


Ser Ser Tyr Leu Tyr Trp Gln Gly Met Ile Ser 
    450                 455                 


<210>  806
<211>  495
<212>  PRT
<213>  Homo Sapiens

<400>  806

Met Trp Gln Ile Val Phe Phe Thr Leu Ser Cys Asp Leu Val Leu Ala 
1               5                   10                  15      


Ala Ala Tyr Asn Asn Phe Arg Lys Ser Met Asp Ser Ile Gly Lys Lys 
            20                  25                  30          


Gln Tyr Gln Val Gln His Gly Ser Cys Ser Tyr Thr Phe Leu Leu Pro 
        35                  40                  45              


Glu Met Asp Asn Cys Arg Ser Ser Ser Ser Pro Tyr Val Ser Asn Ala 
    50                  55                  60                  


Val Gln Arg Asp Ala Pro Leu Glu Tyr Asp Asp Ser Val Gln Arg Leu 
65                  70                  75                  80  


Gln Val Leu Glu Asn Ile Met Glu Asn Asn Thr Gln Trp Leu Met Lys 
                85                  90                  95      


Leu Glu Asn Tyr Ile Gln Asp Asn Met Lys Lys Glu Met Val Glu Ile 
            100                 105                 110         


Gln Gln Asn Ala Val Gln Asn Gln Thr Ala Val Met Ile Glu Ile Gly 
        115                 120                 125             


Thr Asn Leu Leu Asn Gln Thr Ala Glu Gln Thr Arg Lys Leu Thr Asp 
    130                 135                 140                 


Val Glu Ala Gln Val Leu Asn Gln Thr Thr Arg Leu Glu Leu Gln Leu 
145                 150                 155                 160 


Leu Glu His Ser Leu Ser Thr Asn Lys Leu Glu Lys Gln Ile Leu Asp 
                165                 170                 175     


Gln Thr Ser Glu Ile Asn Lys Leu Gln Asp Lys Asn Ser Phe Leu Glu 
            180                 185                 190         


Lys Lys Val Leu Ala Met Glu Asp Lys His Ile Ile Gln Leu Gln Ser 
        195                 200                 205             


Ile Lys Glu Glu Lys Asp Gln Leu Gln Val Leu Val Ser Lys Gln Asn 
    210                 215                 220                 


Ser Ile Ile Glu Glu Leu Glu Lys Lys Ile Val Thr Ala Thr Val Asn 
225                 230                 235                 240 


Asn Ser Val Leu Gln Lys Gln Gln His Asp Leu Met Glu Thr Val Asn 
                245                 250                 255     


Asn Leu Leu Thr Met Met Ser Thr Ser Asn Ser Lys Asp Pro Thr Val 
            260                 265                 270         


Ala Lys Glu Glu Gln Ile Ser Phe Arg Asp Cys Ala Glu Val Phe Lys 
        275                 280                 285             


Ser Gly His Thr Thr Asn Gly Ile Tyr Thr Leu Thr Phe Pro Asn Ser 
    290                 295                 300                 


Thr Glu Glu Ile Lys Ala Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly 
305                 310                 315                 320 


Trp Thr Ile Ile Gln Arg Arg Glu Asp Gly Ser Val Asp Phe Gln Arg 
                325                 330                 335     


Thr Trp Lys Glu Tyr Lys Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr 
            340                 345                 350         


Trp Leu Gly Asn Glu Phe Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr 
        355                 360                 365             


Val Leu Lys Ile His Leu Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser 
    370                 375                 380                 


Leu Tyr Glu His Phe Tyr Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile 
385                 390                 395                 400 


His Leu Lys Gly Leu Thr Gly Thr Ala Gly Lys Ile Ser Ser Ile Ser 
                405                 410                 415     


Gln Pro Gly Asn Asp Phe Ser Thr Lys Asp Gly Asp Asn Asp Lys Cys 
            420                 425                 430         


Ile Cys Lys Cys Ser Gln Met Leu Thr Gly Gly Trp Trp Phe Asp Ala 
        435                 440                 445             


Cys Gly Pro Ser Asn Leu Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn 
    450                 455                 460                 


Thr Asn Lys Phe Asn Gly Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly 
465                 470                 475                 480 


Tyr Ser Leu Lys Ala Thr Thr Met Met Ile Arg Pro Ala Asp Phe 
                485                 490                 495 


<210>  807
<211>  444
<212>  PRT
<213>  Homo Sapiens

<400>  807

Met Trp Gln Ile Val Phe Phe Thr Leu Ser Cys Asp Leu Val Leu Ala 
1               5                   10                  15      


Ala Ala Tyr Asn Asn Phe Arg Lys Ser Met Asp Ser Ile Gly Lys Lys 
            20                  25                  30          


Gln Tyr Gln Val Gln His Gly Ser Cys Ser Tyr Thr Phe Leu Leu Pro 
        35                  40                  45              


Glu Met Asp Asn Cys Arg Ser Ser Ser Ser Pro Tyr Val Ser Asn Ala 
    50                  55                  60                  


Val Gln Arg Asp Ala Pro Leu Glu Tyr Asp Asp Ser Val Gln Arg Leu 
65                  70                  75                  80  


Gln Val Leu Glu Asn Ile Met Glu Asn Asn Thr Gln Trp Leu Met Lys 
                85                  90                  95      


Val Leu Asn Gln Thr Thr Arg Leu Glu Leu Gln Leu Leu Glu His Ser 
            100                 105                 110         


Leu Ser Thr Asn Lys Leu Glu Lys Gln Ile Leu Asp Gln Thr Ser Glu 
        115                 120                 125             


Ile Asn Lys Leu Gln Asp Lys Asn Ser Phe Leu Glu Lys Lys Val Leu 
    130                 135                 140                 


Ala Met Glu Asp Lys His Ile Ile Gln Leu Gln Ser Ile Lys Glu Glu 
145                 150                 155                 160 


Lys Asp Gln Leu Gln Val Leu Val Ser Lys Gln Asn Ser Ile Ile Glu 
                165                 170                 175     


Glu Leu Glu Lys Lys Ile Val Thr Ala Thr Val Asn Asn Ser Val Leu 
            180                 185                 190         


Gln Lys Gln Gln His Asp Leu Met Glu Thr Val Asn Asn Leu Leu Thr 
        195                 200                 205             


Met Met Ser Thr Ser Asn Ser Ala Lys Asp Pro Thr Val Ala Lys Glu 
    210                 215                 220                 


Glu Gln Ile Ser Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His 
225                 230                 235                 240 


Thr Thr Asn Gly Ile Tyr Thr Leu Thr Phe Pro Asn Ser Thr Glu Glu 
                245                 250                 255     


Ile Lys Ala Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr Ile 
            260                 265                 270         


Ile Gln Arg Arg Glu Asp Gly Ser Val Asp Phe Gln Arg Thr Trp Lys 
        275                 280                 285             


Glu Tyr Lys Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly 
    290                 295                 300                 


Asn Glu Phe Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu Lys 
305                 310                 315                 320 


Ile His Leu Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser Leu Tyr Glu 
                325                 330                 335     


His Phe Tyr Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile His Leu Lys 
            340                 345                 350         


Gly Leu Thr Gly Thr Ala Gly Lys Ile Ser Ser Ile Ser Gln Pro Gly 
        355                 360                 365             


Asn Asp Phe Ser Thr Lys Asp Gly Asp Asn Asp Lys Cys Ile Cys Lys 
    370                 375                 380                 


Cys Ser Gln Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro 
385                 390                 395                 400 


Ser Asn Leu Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr Asn Lys 
                405                 410                 415     


Phe Asn Gly Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser Leu 
            420                 425                 430         


Lys Ala Thr Thr Met Met Ile Arg Pro Ala Asp Phe 
        435                 440                 


<210>  808
<211>  503
<212>  PRT
<213>  Homo Sapiens

<400>  808

Met Leu Ser Gln Leu Ala Met Leu Gln Gly Ser Leu Leu Leu Val Val 
1               5                   10                  15      


Ala Thr Met Ser Val Ala Gln Gln Thr Arg Gln Glu Ala Asp Arg Gly 
            20                  25                  30          


Cys Glu Thr Leu Val Val Gln His Gly His Cys Ser Tyr Thr Phe Leu 
        35                  40                  45              


Leu Pro Lys Ser Glu Pro Cys Pro Pro Gly Pro Glu Val Ser Arg Asp 
    50                  55                  60                  


Ser Asn Thr Leu Gln Arg Glu Ser Leu Ala Asn Pro Leu His Leu Gly 
65                  70                  75                  80  


Lys Leu Pro Thr Gln Gln Val Lys Gln Leu Glu Gln Ala Leu Gln Asn 
                85                  90                  95      


Asn Thr Gln Trp Leu Lys Lys Leu Glu Arg Ala Ile Lys Thr Ile Leu 
            100                 105                 110         


Arg Ser Lys Leu Glu Gln Val Gln Gln Gln Met Ala Gln Asn Gln Thr 
        115                 120                 125             


Ala Pro Met Leu Glu Leu Gly Thr Ser Leu Leu Asn Gln Thr Thr Ala 
    130                 135                 140                 


Gln Ile Arg Lys Leu Thr Asp Met Glu Ala Gln Leu Leu Asn Gln Thr 
145                 150                 155                 160 


Ser Arg Met Asp Ala Gln Met Pro Glu Thr Phe Leu Ser Thr Asn Lys 
                165                 170                 175     


Leu Glu Asn Gln Leu Leu Leu Gln Arg Gln Lys Leu Gln Gln Leu Gln 
            180                 185                 190         


Gly Gln Asn Ser Ala Leu Glu Lys Arg Leu Gln Ala Leu Glu Thr Lys 
        195                 200                 205             


Gln Gln Glu Glu Leu Ala Ser Ile Leu Ser Lys Lys Ala Lys Leu Leu 
    210                 215                 220                 


Asn Thr Leu Ser Arg Gln Ser Ala Ala Leu Thr Asn Ile Glu Arg Gly 
225                 230                 235                 240 


Leu Arg Gly Val Arg His Asn Ser Ser Leu Leu Gln Asp Gln Gln His 
                245                 250                 255     


Ser Leu Arg Gln Leu Leu Val Leu Leu Arg His Leu Val Gln Glu Arg 
            260                 265                 270         


Ala Asn Ala Ser Ala Pro Ala Phe Ile Met Ala Gly Glu Gln Val Phe 
        275                 280                 285             


Gln Asp Cys Ala Glu Ile Gln Arg Ser Gly Ala Ser Ala Ser Gly Val 
    290                 295                 300                 


Tyr Thr Ile Gln Val Ser Asn Ala Thr Lys Pro Arg Lys Val Phe Cys 
305                 310                 315                 320 


Asp Leu Gln Ser Ser Gly Gly Arg Trp Thr Leu Ile Gln Arg Arg Glu 
                325                 330                 335     


Asn Gly Thr Val Asn Phe Gln Arg Asn Trp Lys Asp Tyr Lys Gln Gly 
            340                 345                 350         


Phe Gly Asp Pro Ala Gly Glu His Trp Leu Gly Asn Glu Val Val His 
        355                 360                 365             


Gln Leu Thr Arg Arg Ala Ala Tyr Ser Leu Arg Val Glu Leu Gln Asp 
    370                 375                 380                 


Trp Glu Gly His Glu Ala Tyr Ala Gln Tyr Glu His Phe His Leu Gly 
385                 390                 395                 400 


Ser Glu Asn Gln Leu Tyr Arg Leu Ser Val Val Gly Tyr Ser Gly Ser 
                405                 410                 415     


Ala Gly Arg Gln Ser Ser Leu Val Leu Gln Asn Thr Ser Phe Ser Thr 
            420                 425                 430         


Leu Asp Ser Asp Asn Asp His Cys Leu Cys Lys Cys Ala Gln Val Met 
        435                 440                 445             


Ser Gly Gly Trp Trp Phe Asp Ala Cys Gly Leu Ser Asn Leu Asn Gly 
    450                 455                 460                 


Val Tyr Tyr His Ala Pro Asp Asn Lys Tyr Lys Met Asp Gly Ile Arg 
465                 470                 475                 480 


Trp His Tyr Phe Lys Gly Pro Ser Tyr Ser Leu Arg Ala Ser Arg Met 
                485                 490                 495     


Met Ile Arg Pro Leu Asp Ile 
            500             


<210>  809
<211>  114
<212>  PRT
<213>  Homo Sapiens

<400>  809

Met Lys Thr Phe Thr Trp Thr Leu Gly Val Leu Phe Phe Leu Leu Val 
1               5                   10                  15      


Asp Thr Gly His Cys Arg Gly Gly Gln Phe Lys Ile Lys Lys Ile Asn 
            20                  25                  30          


Gln Arg Arg Tyr Pro Arg Ala Thr Asp Gly Lys Glu Glu Ala Lys Lys 
        35                  40                  45              


Cys Ala Tyr Thr Phe Leu Val Pro Glu Gln Arg Ile Thr Gly Pro Ile 
    50                  55                  60                  


Cys Val Asn Thr Lys Gly Gln Asp Ala Ser Thr Ile Lys Asp Met Ile 
65                  70                  75                  80  


Thr Arg Met Asp Leu Glu Asn Leu Lys Asp Val Leu Ser Arg Gln Lys 
                85                  90                  95      


Arg Glu Ile Asp Val Leu Gln Leu Val Val Asp Val Asp Gly Asn Ile 
            100                 105                 110         


Val Asn 
        


<210>  810
<211>  491
<212>  PRT
<213>  Homo Sapiens

<400>  810

Met Lys Thr Phe Thr Trp Thr Leu Gly Val Leu Phe Phe Leu Leu Val 
1               5                   10                  15      


Asp Thr Gly His Cys Arg Gly Gly Gln Phe Lys Ile Lys Lys Ile Asn 
            20                  25                  30          


Gln Arg Arg Tyr Pro Arg Ala Thr Asp Gly Lys Glu Glu Ala Lys Lys 
        35                  40                  45              


Cys Ala Tyr Thr Phe Leu Val Pro Glu Gln Arg Ile Thr Gly Pro Ile 
    50                  55                  60                  


Cys Val Asn Thr Lys Gly Gln Asp Ala Ser Thr Ile Lys Asp Met Ile 
65                  70                  75                  80  


Thr Arg Met Asp Leu Glu Asn Leu Lys Asp Val Leu Ser Arg Gln Lys 
                85                  90                  95      


Arg Glu Ile Asp Val Leu Gln Leu Val Val Asp Val Asp Gly Asn Ile 
            100                 105                 110         


Val Asn Glu Val Lys Leu Leu Arg Lys Glu Ser Arg Asn Met Asn Ser 
        115                 120                 125             


Arg Val Thr Gln Leu Tyr Met Gln Leu Leu His Glu Ile Ile Arg Lys 
    130                 135                 140                 


Arg Asp Asn Ser Leu Glu Leu Ser Gln Leu Glu Asn Lys Ile Leu Asn 
145                 150                 155                 160 


Val Thr Thr Glu Met Leu Lys Met Ala Thr Arg Tyr Arg Glu Leu Glu 
                165                 170                 175     


Val Lys Tyr Ala Ser Leu Thr Asp Leu Val Asn Asn Gln Ser Val Met 
            180                 185                 190         


Ile Thr Leu Leu Glu Glu Gln Cys Leu Arg Ile Phe Ser Arg Gln Asp 
        195                 200                 205             


Thr His Val Ser Pro Pro Leu Val Gln Val Val Pro Gln His Ile Pro 
    210                 215                 220                 


Asn Ser Gln Gln Tyr Thr Pro Gly Leu Leu Gly Gly Asn Glu Ile Gln 
225                 230                 235                 240 


Arg Asp Pro Gly Tyr Pro Arg Asp Leu Met Pro Pro Pro Asp Leu Ala 
                245                 250                 255     


Thr Ser Pro Thr Lys Ser Pro Phe Lys Ile Pro Pro Val Thr Phe Ile 
            260                 265                 270         


Asn Glu Gly Pro Phe Lys Asp Cys Gln Gln Ala Lys Glu Ala Gly His 
        275                 280                 285             


Ser Val Ser Gly Ile Tyr Met Ile Lys Pro Glu Asn Ser Asn Gly Pro 
    290                 295                 300                 


Met Gln Leu Trp Cys Glu Asn Ser Leu Asp Pro Gly Gly Trp Thr Val 
305                 310                 315                 320 


Ile Gln Lys Arg Thr Asp Gly Ser Val Asn Phe Phe Arg Asn Trp Glu 
                325                 330                 335     


Asn Tyr Lys Lys Gly Phe Gly Asn Ile Asp Gly Glu Tyr Trp Leu Gly 
            340                 345                 350         


Leu Glu Asn Ile Tyr Met Leu Ser Asn Gln Asp Asn Tyr Lys Leu Leu 
        355                 360                 365             


Ile Glu Leu Glu Asp Trp Ser Asp Lys Lys Val Tyr Ala Glu Tyr Ser 
    370                 375                 380                 


Ser Phe Arg Leu Glu Pro Glu Ser Glu Phe Tyr Arg Leu Arg Leu Gly 
385                 390                 395                 400 


Thr Tyr Gln Gly Asn Ala Gly Asp Ser Met Met Trp His Asn Gly Lys 
                405                 410                 415     


Gln Phe Thr Thr Leu Asp Arg Asp Lys Asp Met Tyr Ala Gly Asn Cys 
            420                 425                 430         


Ala His Phe His Lys Gly Gly Trp Trp Tyr Asn Ala Cys Ala His Ser 
        435                 440                 445             


Asn Leu Asn Gly Val Trp Tyr Arg Gly Gly His Tyr Arg Ser Lys His 
    450                 455                 460                 


Gln Asp Gly Ile Phe Trp Ala Glu Tyr Arg Gly Gly Ser Tyr Ser Leu 
465                 470                 475                 480 


Arg Ala Val Gln Met Met Ile Lys Pro Ile Asp 
                485                 490     


<210>  811
<211>  491
<212>  PRT
<213>  Homo Sapiens

<400>  811

Met Lys Thr Phe Thr Trp Thr Leu Gly Val Leu Phe Phe Leu Leu Val 
1               5                   10                  15      


Asp Thr Gly His Cys Arg Gly Gly Gln Phe Lys Ile Lys Lys Ile Asn 
            20                  25                  30          


Gln Arg Arg Tyr Pro Arg Ala Thr Asp Gly Lys Glu Glu Ala Lys Lys 
        35                  40                  45              


Cys Ala Tyr Thr Phe Leu Val Pro Glu Gln Arg Ile Thr Gly Pro Ile 
    50                  55                  60                  


Cys Val Asn Thr Lys Gly Gln Asp Ala Ser Thr Ile Lys Asp Met Ile 
65                  70                  75                  80  


Thr Arg Met Asp Leu Glu Asn Leu Lys Asp Val Leu Ser Arg Gln Lys 
                85                  90                  95      


Arg Glu Ile Asp Val Leu Gln Leu Val Val Asp Val Asp Gly Asn Ile 
            100                 105                 110         


Val Asn Glu Val Lys Leu Leu Arg Lys Glu Ser Arg Asn Met Asn Ser 
        115                 120                 125             


Arg Val Thr Gln Leu Tyr Met Gln Leu Leu His Glu Ile Ile Arg Lys 
    130                 135                 140                 


Arg Asp Asn Ser Leu Glu Leu Ser Gln Leu Glu Asn Lys Ile Leu Asn 
145                 150                 155                 160 


Val Thr Thr Glu Met Leu Lys Met Ala Thr Arg Tyr Arg Glu Leu Glu 
                165                 170                 175     


Val Lys Tyr Ala Ser Leu Thr Asp Leu Val Asn Asn Gln Ser Val Met 
            180                 185                 190         


Ile Thr Leu Leu Glu Glu Gln Cys Leu Arg Ile Phe Ser Arg Gln Asp 
        195                 200                 205             


Thr His Val Ser Pro Pro Leu Val Gln Val Val Pro Gln His Ile Pro 
    210                 215                 220                 


Asn Ser Gln Gln Tyr Thr Pro Gly Leu Leu Gly Gly Asn Glu Ile Gln 
225                 230                 235                 240 


Arg Asp Pro Gly Tyr Pro Arg Asp Leu Met Pro Pro Pro Asp Leu Ala 
                245                 250                 255     


Thr Ser Pro Thr Lys Ser Pro Phe Lys Ile Pro Pro Val Thr Phe Ile 
            260                 265                 270         


Asn Glu Gly Pro Phe Lys Asp Cys Gln Gln Ala Lys Glu Ala Gly His 
        275                 280                 285             


Ser Val Ser Gly Ile Tyr Met Ile Lys Pro Glu Asn Ser Asn Gly Pro 
    290                 295                 300                 


Met Gln Leu Trp Cys Glu Asn Ser Leu Asp Pro Gly Gly Trp Thr Val 
305                 310                 315                 320 


Ile Gln Lys Arg Thr Asp Gly Ser Val Asn Phe Phe Arg Asn Trp Glu 
                325                 330                 335     


Asn Tyr Lys Lys Gly Phe Gly Asn Ile Asp Gly Glu Tyr Trp Leu Gly 
            340                 345                 350         


Leu Glu Asn Ile Tyr Met Leu Ser Asn Gln Asp Asn Tyr Lys Leu Leu 
        355                 360                 365             


Ile Glu Leu Glu Asp Trp Ser Asp Lys Lys Val Tyr Ala Glu Tyr Ser 
    370                 375                 380                 


Ser Phe Arg Leu Glu Pro Glu Ser Glu Phe Tyr Arg Leu Arg Leu Gly 
385                 390                 395                 400 


Thr Tyr Gln Gly Asn Ala Gly Asp Ser Met Met Trp His Asn Gly Lys 
                405                 410                 415     


Gln Phe Thr Thr Leu Asp Arg Asp Lys Asp Met Tyr Ala Gly Asn Cys 
            420                 425                 430         


Ala His Phe His Lys Gly Gly Trp Trp Tyr Asn Ala Cys Ala His Ser 
        435                 440                 445             


Asn Leu Asn Gly Val Trp Tyr Arg Gly Gly His Tyr Arg Ser Lys His 
    450                 455                 460                 


Gln Asp Gly Ile Phe Trp Ala Glu Tyr Arg Gly Gly Ser Tyr Ser Leu 
465                 470                 475                 480 


Arg Ala Val Gln Met Met Ile Lys Pro Ile Asp 
                485                 490     


<210>  812
<211>  191
<212>  PRT
<213>  Homo Sapiens

<400>  812

Met Gln Val Trp Cys Asp Gln Arg His Asp Pro Gly Gly Trp Thr Val 
1               5                   10                  15      


Ile Gln Arg Arg Leu Asp Gly Ser Val Asn Phe Phe Arg Asn Trp Glu 
            20                  25                  30          


Thr Tyr Lys Gln Gly Phe Gly Asn Ile Asp Gly Glu Tyr Trp Leu Gly 
        35                  40                  45              


Leu Glu Asn Ile Tyr Trp Leu Thr Asn Gln Gly Asn Tyr Lys Leu Leu 
    50                  55                  60                  


Val Thr Met Glu Asp Trp Ser Gly Arg Lys Val Phe Ala Glu Tyr Ala 
65                  70                  75                  80  


Ser Phe Arg Leu Glu Pro Glu Ser Glu Tyr Tyr Lys Leu Arg Leu Gly 
                85                  90                  95      


Arg Tyr His Gly Asn Ala Gly Asp Ser Phe Thr Trp His Asn Gly Lys 
            100                 105                 110         


Gln Phe Thr Thr Leu Asp Arg Asp His Asp Val Tyr Thr Gly Asn Cys 
        115                 120                 125             


Ala His Tyr Gln Lys Gly Gly Trp Trp Tyr Asn Ala Cys Ala His Ser 
    130                 135                 140                 


Asn Leu Asn Gly Val Trp Tyr Arg Gly Gly His Tyr Arg Ser Arg Tyr 
145                 150                 155                 160 


Gln Asp Gly Val Tyr Trp Ala Glu Phe Arg Gly Gly Ser Tyr Ser Leu 
                165                 170                 175     


Lys Lys Val Val Met Met Ile Arg Pro Asn Pro Asn Thr Phe His 
            180                 185                 190     


<210>  813
<211>  493
<212>  PRT
<213>  Homo Sapiens

<400>  813

Met Arg Pro Leu Cys Val Thr Cys Trp Trp Leu Gly Leu Leu Ala Ala 
1               5                   10                  15      


Met Gly Ala Val Ala Gly Gln Glu Asp Gly Phe Glu Gly Thr Glu Glu 
            20                  25                  30          


Gly Ser Pro Arg Glu Phe Ile Tyr Leu Asn Arg Tyr Lys Arg Ala Gly 
        35                  40                  45              


Glu Ser Gln Asp Lys Cys Thr Tyr Thr Phe Ile Val Pro Gln Gln Arg 
    50                  55                  60                  


Val Thr Gly Ala Ile Cys Val Asn Ser Lys Glu Pro Glu Val Leu Leu 
65                  70                  75                  80  


Glu Asn Arg Val His Lys Gln Glu Leu Glu Leu Leu Asn Asn Glu Leu 
                85                  90                  95      


Leu Lys Gln Lys Arg Gln Ile Glu Thr Leu Gln Gln Leu Val Glu Val 
            100                 105                 110         


Asp Gly Gly Ile Val Ser Glu Val Lys Leu Leu Arg Lys Glu Ser Arg 
        115                 120                 125             


Asn Met Asn Ser Arg Val Thr Gln Leu Tyr Met Gln Leu Leu His Glu 
    130                 135                 140                 


Ile Ile Arg Lys Arg Asp Asn Ala Leu Glu Leu Ser Gln Leu Glu Asn 
145                 150                 155                 160 


Arg Ile Leu Asn Gln Thr Ala Asp Met Leu Gln Leu Ala Ser Lys Tyr 
                165                 170                 175     


Lys Asp Leu Glu His Lys Tyr Gln His Leu Ala Thr Leu Ala His Asn 
            180                 185                 190         


Gln Ser Glu Ile Ile Ala Gln Leu Glu Glu His Cys Gln Arg Val Pro 
        195                 200                 205             


Ser Ala Arg Pro Val Pro Gln Pro Pro Pro Ala Ala Pro Pro Arg Val 
    210                 215                 220                 


Tyr Gln Pro Pro Thr Tyr Asn Arg Ile Ile Asn Gln Ile Ser Thr Asn 
225                 230                 235                 240 


Glu Ile Gln Ser Asp Gln Asn Leu Lys Val Leu Pro Pro Pro Leu Pro 
                245                 250                 255     


Thr Met Pro Thr Leu Thr Ser Leu Pro Ser Ser Thr Asp Lys Pro Ser 
            260                 265                 270         


Gly Pro Trp Arg Asp Cys Leu Gln Ala Leu Glu Asp Gly His Asp Thr 
        275                 280                 285             


Ser Ser Ile Tyr Leu Val Lys Pro Glu Asn Thr Asn Arg Leu Met Gln 
    290                 295                 300                 


Val Trp Cys Asp Gln Arg His Asp Pro Gly Gly Trp Thr Val Ile Gln 
305                 310                 315                 320 


Arg Arg Leu Asp Gly Ser Val Asn Phe Phe Arg Asn Trp Glu Thr Tyr 
                325                 330                 335     


Lys Gln Gly Phe Gly Asn Ile Asp Gly Glu Tyr Trp Leu Gly Leu Glu 
            340                 345                 350         


Asn Ile Tyr Trp Leu Thr Asn Gln Gly Asn Tyr Lys Leu Leu Val Thr 
        355                 360                 365             


Met Glu Asp Trp Ser Gly Arg Lys Val Phe Ala Glu Tyr Ala Ser Phe 
    370                 375                 380                 


Arg Leu Glu Pro Glu Ser Glu Tyr Tyr Lys Leu Arg Leu Gly Arg Tyr 
385                 390                 395                 400 


His Gly Asn Ala Gly Asp Ser Phe Thr Trp His Asn Gly Lys Gln Phe 
                405                 410                 415     


Thr Thr Leu Asp Arg Asp His Asp Val Tyr Thr Gly Asn Cys Ala His 
            420                 425                 430         


Tyr Gln Lys Gly Gly Trp Trp Tyr Asn Ala Cys Ala His Ser Asn Leu 
        435                 440                 445             


Asn Gly Val Trp Tyr Arg Gly Gly His Tyr Arg Ser Arg Tyr Gln Asp 
    450                 455                 460                 


Gly Val Tyr Trp Ala Glu Phe Arg Gly Gly Ser Tyr Ser Leu Lys Lys 
465                 470                 475                 480 


Val Val Met Met Ile Arg Pro Asn Pro Asn Thr Phe His 
                485                 490             


<210>  814
<211>  460
<212>  PRT
<213>  Homo Sapiens

<400>  814

Met Phe Thr Ile Lys Leu Leu Leu Phe Ile Val Pro Leu Val Ile Ser 
1               5                   10                  15      


Ser Arg Ile Asp Gln Asp Asn Ser Ser Phe Asp Ser Leu Ser Pro Glu 
            20                  25                  30          


Pro Lys Ser Arg Phe Ala Met Leu Asp Asp Val Lys Ile Leu Ala Asn 
        35                  40                  45              


Gly Leu Leu Gln Leu Gly His Gly Leu Lys Asp Phe Val His Lys Thr 
    50                  55                  60                  


Lys Gly Gln Ile Asn Asp Ile Phe Gln Lys Leu Asn Ile Phe Asp Gln 
65                  70                  75                  80  


Ser Phe Tyr Asp Leu Ser Leu Gln Thr Ser Glu Ile Lys Glu Glu Glu 
                85                  90                  95      


Lys Glu Leu Arg Arg Thr Thr Tyr Lys Leu Gln Val Lys Asn Glu Glu 
            100                 105                 110         


Val Lys Asn Met Ser Leu Glu Leu Asn Ser Lys Leu Glu Ser Leu Leu 
        115                 120                 125             


Glu Glu Lys Ile Leu Leu Gln Gln Lys Val Lys Tyr Leu Glu Glu Gln 
    130                 135                 140                 


Leu Thr Asn Leu Ile Gln Asn Gln Pro Glu Thr Pro Glu His Pro Glu 
145                 150                 155                 160 


Val Thr Ser Leu Lys Thr Phe Val Glu Lys Gln Asp Asn Ser Ile Lys 
                165                 170                 175     


Asp Leu Leu Gln Thr Val Glu Asp Gln Tyr Lys Gln Leu Asn Gln Gln 
            180                 185                 190         


His Ser Gln Ile Lys Glu Ile Glu Asn Gln Leu Arg Arg Thr Ser Ile 
        195                 200                 205             


Gln Glu Pro Thr Glu Ile Ser Leu Ser Ser Lys Pro Arg Ala Pro Arg 
    210                 215                 220                 


Thr Thr Pro Phe Leu Gln Leu Asn Glu Ile Arg Asn Val Lys His Asp 
225                 230                 235                 240 


Gly Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr 
                245                 250                 255     


Ser Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val 
            260                 265                 270         


Tyr Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg 
        275                 280                 285             


Ile Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr 
    290                 295                 300                 


Gly Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile 
305                 310                 315                 320 


Tyr Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu 
                325                 330                 335     


Asp Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly 
            340                 345                 350         


Asn His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn 
        355                 360                 365             


Val Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp 
    370                 375                 380                 


Asp His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly 
385                 390                 395                 400 


Gly Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys 
                405                 410                 415     


Tyr Asn Lys Pro Arg Ala Lys Ser Lys Pro Glu Arg Arg Arg Gly Leu 
            420                 425                 430         


Ser Trp Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys 
        435                 440                 445             


Met Leu Ile His Pro Thr Asp Ser Glu Ser Phe Glu 
    450                 455                 460 


<210>  815
<211>  86
<212>  PRT
<213>  Homo Sapiens

<400>  815

Met Ser Gly Ala Pro Thr Ala Gly Ala Ala Leu Met Leu Cys Ala Ala 
1               5                   10                  15      


Thr Ala Val Leu Leu Ser Ala Gln Gly Gly Pro Val Gln Ser Lys Ser 
            20                  25                  30          


Pro Arg Phe Ala Ser Trp Asp Glu Met Asn Val Leu Ala His Gly Leu 
        35                  40                  45              


Leu Gln Leu Gly Gln Gly Leu Arg Glu His Ala Glu Arg Thr Arg Ser 
    50                  55                  60                  


Gln Leu Ser Ala Leu Glu Arg Arg Leu Ser Ala Cys Gly Ser Ala Cys 
65                  70                  75                  80  


Gln Gly Thr Glu Gly Ser 
                85      


<210>  816
<211>  96
<212>  PRT
<213>  Homo Sapiens

<400>  816

Met Ser Gly Ala Pro Thr Ala Gly Ala Ala Leu Met Leu Cys Ala Ala 
1               5                   10                  15      


Thr Ala Val Leu Leu Ser Ala Gln Gly Gly Pro Val Gln Ser Lys Ser 
            20                  25                  30          


Pro Arg Phe Ala Ser Trp Asp Glu Met Asn Val Leu Ala His Gly Leu 
        35                  40                  45              


Leu Gln Leu Gly Gln Gly Leu Arg Glu His Ala Glu Arg Thr Arg Ser 
    50                  55                  60                  


Gln Leu Ser Ala Leu Glu Arg Arg Leu Ser Ala Cys Gly Ser Ala Cys 
65                  70                  75                  80  


Gln Gly Thr Glu Gly Ser Thr Asp Leu Pro Leu Ala Pro Glu Ser Arg 
                85                  90                  95      


<210>  817
<211>  105
<212>  PRT
<213>  Homo Sapiens

<400>  817

Met Ser Gly Ala Pro Thr Ala Gly Ala Ala Leu Met Leu Cys Ala Ala 
1               5                   10                  15      


Thr Ala Val Leu Leu Ser Ala Gln Gly Gly Pro Val Gln Ser Lys Ser 
            20                  25                  30          


Pro Arg Phe Ala Ser Trp Asp Glu Met Asn Val Leu Ala His Gly Leu 
        35                  40                  45              


Leu Gln Leu Gly Gln Gly Leu Arg Glu His Ala Glu Arg Thr Arg Ser 
    50                  55                  60                  


Gln Leu Ser Ala Leu Glu Arg Arg Leu Ser Ala Cys Gly Ser Ala Cys 
65                  70                  75                  80  


Gln Gly Thr Glu Gly Ser Thr Asp Leu Pro Leu Ala Pro Glu Ser Arg 
                85                  90                  95      


Val Asp Pro Glu Val Leu His Ser Leu 
            100                 105 


<210>  818
<211>  368
<212>  PRT
<213>  Homo Sapiens

<400>  818

Met Ser Gly Ala Pro Thr Ala Gly Ala Ala Leu Met Leu Cys Ala Ala 
1               5                   10                  15      


Thr Ala Val Leu Leu Ser Ala Gln Gly Gly Pro Val Gln Ser Lys Ser 
            20                  25                  30          


Pro Arg Phe Ala Ser Trp Asp Glu Met Asn Val Leu Ala His Gly Leu 
        35                  40                  45              


Leu Gln Leu Gly Gln Gly Leu Arg Glu His Ala Glu Arg Thr Arg Ser 
    50                  55                  60                  


Gln Leu Ser Ala Leu Glu Arg Arg Leu Ser Ala Cys Gly Ser Ala Cys 
65                  70                  75                  80  


Gln Gly Thr Glu Gly Ser Thr Asp Leu Pro Leu Ala Pro Glu Ser Arg 
                85                  90                  95      


Val Asp Pro Glu Val Leu His Ser Leu Gln Thr Gln Leu Lys Ala Gln 
            100                 105                 110         


Asn Ser Arg Ile Gln Gln Leu Phe His Lys Val Ala Gln Gln Gln Arg 
        115                 120                 125             


His Leu Glu Lys Gln His Leu Arg Ile Gln His Leu Gln Ser Gln Phe 
    130                 135                 140                 


Gly Leu Leu Asp His Lys His Leu Asp His Glu Val Ala Lys Pro Ala 
145                 150                 155                 160 


Arg Arg Lys Arg Leu Pro Glu Met Ala Gln Pro Val Asp Pro Ala His 
                165                 170                 175     


Asn Val Ser Arg Leu His His Gly Gly Trp Thr Val Ile Gln Arg Arg 
            180                 185                 190         


His Asp Gly Ser Val Asp Phe Asn Arg Pro Trp Glu Ala Tyr Lys Ala 
        195                 200                 205             


Gly Phe Gly Asp Pro His Gly Glu Phe Trp Leu Gly Leu Glu Lys Val 
    210                 215                 220                 


His Ser Ile Thr Gly Asp Arg Asn Ser Arg Leu Ala Val Gln Leu Arg 
225                 230                 235                 240 


Asp Trp Asp Gly Asn Ala Glu Leu Leu Gln Phe Ser Val His Leu Gly 
                245                 250                 255     


Gly Glu Asp Thr Ala Tyr Ser Leu Gln Leu Thr Ala Pro Val Ala Gly 
            260                 265                 270         


Gln Leu Gly Ala Thr Thr Val Pro Pro Ser Gly Leu Ser Val Pro Phe 
        275                 280                 285             


Ser Thr Trp Asp Gln Asp His Asp Leu Arg Arg Asp Lys Asn Cys Ala 
    290                 295                 300                 


Lys Ser Leu Ser Gly Gly Trp Trp Phe Gly Thr Cys Ser His Ser Asn 
305                 310                 315                 320 


Leu Asn Gly Gln Tyr Phe Arg Ser Ile Pro Gln Gln Arg Gln Lys Leu 
                325                 330                 335     


Lys Lys Gly Ile Phe Trp Lys Thr Trp Arg Gly Arg Tyr Tyr Pro Leu 
            340                 345                 350         


Gln Ala Thr Thr Met Leu Ile Gln Pro Met Ala Ala Glu Ala Ala Ser 
        355                 360                 365             


<210>  819
<211>  406
<212>  PRT
<213>  Homo Sapiens

<400>  819

Met Ser Gly Ala Pro Thr Ala Gly Ala Ala Leu Met Leu Cys Ala Ala 
1               5                   10                  15      


Thr Ala Val Leu Leu Ser Ala Gln Gly Gly Pro Val Gln Ser Lys Ser 
            20                  25                  30          


Pro Arg Phe Ala Ser Trp Asp Glu Met Asn Val Leu Ala His Gly Leu 
        35                  40                  45              


Leu Gln Leu Gly Gln Gly Leu Arg Glu His Ala Glu Arg Thr Arg Ser 
    50                  55                  60                  


Gln Leu Ser Ala Leu Glu Arg Arg Leu Ser Ala Cys Gly Ser Ala Cys 
65                  70                  75                  80  


Gln Gly Thr Glu Gly Ser Thr Asp Leu Pro Leu Ala Pro Glu Ser Arg 
                85                  90                  95      


Val Asp Pro Glu Val Leu His Ser Leu Gln Thr Gln Leu Lys Ala Gln 
            100                 105                 110         


Asn Ser Arg Ile Gln Gln Leu Phe His Lys Val Ala Gln Gln Gln Arg 
        115                 120                 125             


His Leu Glu Lys Gln His Leu Arg Ile Gln His Leu Gln Ser Gln Phe 
    130                 135                 140                 


Gly Leu Leu Asp His Lys His Leu Asp His Glu Val Ala Lys Pro Ala 
145                 150                 155                 160 


Arg Arg Lys Arg Leu Pro Glu Met Ala Gln Pro Val Asp Pro Ala His 
                165                 170                 175     


Asn Val Ser Arg Leu His Arg Leu Pro Arg Asp Cys Gln Glu Leu Phe 
            180                 185                 190         


Gln Val Gly Glu Arg Gln Ser Gly Leu Phe Glu Ile Gln Pro Gln Gly 
        195                 200                 205             


Ser Pro Pro Phe Leu Val Asn Cys Lys Met Thr Ser Asp Gly Gly Trp 
    210                 215                 220                 


Thr Val Ile Gln Arg Arg His Asp Gly Ser Val Asp Phe Asn Arg Pro 
225                 230                 235                 240 


Trp Glu Ala Tyr Lys Ala Gly Phe Gly Asp Pro His Gly Glu Phe Trp 
                245                 250                 255     


Leu Gly Leu Glu Lys Val His Ser Ile Thr Gly Asp Arg Asn Ser Arg 
            260                 265                 270         


Leu Ala Val Gln Leu Arg Asp Trp Asp Gly Asn Ala Glu Leu Leu Gln 
        275                 280                 285             


Phe Ser Val His Leu Gly Gly Glu Asp Thr Ala Tyr Ser Leu Gln Leu 
    290                 295                 300                 


Thr Ala Pro Val Ala Gly Gln Leu Gly Ala Thr Thr Val Pro Pro Ser 
305                 310                 315                 320 


Gly Leu Ser Val Pro Phe Ser Thr Trp Asp Gln Asp His Asp Leu Arg 
                325                 330                 335     


Arg Asp Lys Asn Cys Ala Lys Ser Leu Ser Gly Gly Trp Trp Phe Gly 
            340                 345                 350         


Thr Cys Ser His Ser Asn Leu Asn Gly Gln Tyr Phe Arg Ser Ile Pro 
        355                 360                 365             


Gln Gln Arg Gln Lys Leu Lys Lys Gly Ile Phe Trp Lys Thr Trp Arg 
    370                 375                 380                 


Gly Arg Tyr Tyr Pro Leu Gln Ala Thr Thr Met Leu Ile Gln Pro Met 
385                 390                 395                 400 


Ala Ala Glu Ala Ala Ser 
                405     


<210>  820
<211>  406
<212>  PRT
<213>  Homo Sapiens

<400>  820

Met Ser Gly Ala Pro Thr Ala Gly Ala Ala Leu Met Leu Cys Ala Ala 
1               5                   10                  15      


Thr Ala Val Leu Leu Ser Ala Gln Gly Gly Pro Val Gln Ser Lys Ser 
            20                  25                  30          


Pro Arg Phe Ala Ser Trp Asp Glu Met Asn Val Leu Ala His Gly Leu 
        35                  40                  45              


Leu Gln Leu Gly Gln Gly Leu Arg Glu His Ala Glu Arg Thr Arg Ser 
    50                  55                  60                  


Gln Leu Ser Ala Leu Glu Arg Arg Leu Ser Ala Cys Gly Ser Ala Cys 
65                  70                  75                  80  


Gln Gly Thr Glu Gly Ser Thr Asp Leu Pro Leu Ala Pro Glu Ser Arg 
                85                  90                  95      


Val Asp Pro Glu Val Leu His Ser Leu Gln Thr Gln Leu Lys Ala Gln 
            100                 105                 110         


Asn Ser Arg Ile Gln Gln Leu Phe His Lys Val Ala Gln Gln Gln Arg 
        115                 120                 125             


His Leu Glu Lys Gln His Leu Arg Ile Gln His Leu Gln Ser Gln Phe 
    130                 135                 140                 


Gly Leu Leu Asp His Lys His Leu Asp His Glu Val Ala Lys Pro Ala 
145                 150                 155                 160 


Arg Arg Lys Arg Leu Pro Glu Met Ala Gln Pro Val Asp Pro Ala His 
                165                 170                 175     


Asn Val Ser Arg Leu His Arg Leu Pro Arg Asp Cys Gln Glu Leu Phe 
            180                 185                 190         


Gln Val Gly Glu Arg Gln Ser Gly Leu Phe Glu Ile Gln Pro Gln Gly 
        195                 200                 205             


Ser Pro Pro Phe Leu Val Asn Cys Lys Met Thr Ser Asp Gly Gly Trp 
    210                 215                 220                 


Thr Val Ile Gln Arg Arg His Asp Gly Ser Val Asp Phe Asn Arg Pro 
225                 230                 235                 240 


Trp Glu Ala Tyr Lys Ala Gly Phe Gly Asp Pro His Gly Glu Phe Trp 
                245                 250                 255     


Leu Gly Leu Glu Lys Val His Ser Ile Thr Gly Asp Arg Asn Ser Arg 
            260                 265                 270         


Leu Ala Val Gln Leu Arg Asp Trp Asp Gly Asn Ala Glu Leu Leu Gln 
        275                 280                 285             


Phe Ser Val His Leu Gly Gly Glu Asp Thr Ala Tyr Ser Leu Gln Leu 
    290                 295                 300                 


Thr Ala Pro Val Ala Gly Gln Leu Gly Ala Thr Thr Val Pro Pro Ser 
305                 310                 315                 320 


Gly Leu Ser Val Pro Phe Ser Thr Trp Asp Gln Asp His Asp Leu Arg 
                325                 330                 335     


Arg Asp Lys Asn Cys Ala Lys Ser Leu Ser Gly Gly Trp Trp Phe Gly 
            340                 345                 350         


Thr Cys Ser His Ser Asn Leu Asn Gly Gln Tyr Phe Arg Ser Ile Pro 
        355                 360                 365             


Gln Gln Arg Gln Lys Leu Lys Lys Gly Ile Phe Trp Lys Thr Trp Arg 
    370                 375                 380                 


Gly Arg Tyr Tyr Pro Leu Gln Ala Thr Thr Met Leu Ile Gln Pro Met 
385                 390                 395                 400 


Ala Ala Glu Ala Ala Ser 
                405     


<210>  821
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  821

Met Ser Gly Ala Pro Thr Ala Gly Ala Ala Leu Met Leu Cys Ala Ala 
1               5                   10                  15      


Thr Ala Val Leu Leu Ser Ala Gln Gly Gly Pro Val Gln Ser Lys Ser 
            20                  25                  30          


Pro Arg Phe Ala Ser Trp Asp Glu Met Asn Val Leu Ala His Gly Leu 
        35                  40                  45              


Leu Gln Leu Gly Gln Gly Leu Arg Glu His Ala Glu Arg Thr Arg Ser 
    50                  55                  60                  


Gln Leu Ser Ala Leu Glu Arg Arg Leu Ser Ala Cys Gly Ser Phe Thr 
65                  70                  75                  80  


Ala Cys Arg His Asn Ser Arg Leu Arg Thr Ala Gly Ser Ser Asn Ser 
                85                  90                  95      


Ser Thr Arg Trp Pro Ser Ser Ser Gly Thr Trp Arg Ser Ser Thr Cys 
            100                 105                 110         


Glu Phe Ser Ile Cys Lys Ala Ser Leu Ala Ser Trp Thr Thr Ser Thr 
        115                 120                 125             


<210>  822
<211>  129
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  822

Xaa Pro Val Gln Ser Lys Ser Pro Arg Phe Ala Ser Trp Asp Glu Met 
1               5                   10                  15      


Asn Val Leu Ala His Gly Leu Leu Gln Leu Gly Gln Gly Leu Arg Glu 
            20                  25                  30          


His Ala Glu Arg Thr Arg Ser Gln Leu Ser Ala Leu Glu Arg Arg Leu 
        35                  40                  45              


Ser Ala Cys Gly Ser Ala Cys Gln Gly Thr Glu Gly Ser Thr Asp Leu 
    50                  55                  60                  


Pro Leu Ala Pro Glu Ser Arg Val Asp Pro Glu Val Leu His Ser Leu 
65                  70                  75                  80  


Gln Thr Gln Leu Lys Ala Gln Asn Ser Arg Ile Gln Gln Leu Phe His 
                85                  90                  95      


Lys Val Ala Gln Gln Gln Arg His Leu Glu Lys Gln His Leu Arg Ile 
            100                 105                 110         


Gln His Leu Gln Ser Gln Thr Gly Leu Asn Gly Gly Leu Ser His Ile 
        115                 120                 125             


Asp 
    


<210>  823
<211>  192
<212>  PRT
<213>  Homo Sapiens

<400>  823

Met Met Ser Pro Ser Gln Ala Ser Leu Leu Phe Leu Asn Val Cys Ile 
1               5                   10                  15      


Phe Ile Cys Gly Glu Ala Val Gln Gly Asn Cys Val His His Ser Thr 
            20                  25                  30          


Asp Ser Ser Val Val Asn Ile Val Glu Asp Gly Ser Asn Ala Lys Asp 
        35                  40                  45              


Glu Ser Lys Ser Asn Asp Thr Val Cys Lys Glu Asp Cys Glu Glu Ser 
    50                  55                  60                  


Cys Asp Val Lys Thr Lys Ile Thr Arg Glu Glu Lys His Phe Met Cys 
65                  70                  75                  80  


Arg Asn Leu Gln Asn Ser Ile Val Ser Tyr Thr Arg Ser Thr Lys Lys 
                85                  90                  95      


Leu Leu Arg Asn Met Met Asp Glu Gln Gln Ala Ser Leu Asp Tyr Leu 
            100                 105                 110         


Ser Asn Gln Val Met Cys Asp Met Asp Tyr Arg Gly Gly Gly Arg Thr 
        115                 120                 125             


Val Ile Gln Lys Arg Ile Asp Gly Ile Ile Asp Phe Gln Arg Leu Trp 
    130                 135                 140                 


Cys Asp Tyr Leu Asp Gly Phe Gly Asp Leu Leu Gly Glu Phe Trp Leu 
145                 150                 155                 160 


Gly Leu Lys Lys Ile Phe Tyr Ile Val Asn Gln Lys Asn Thr Ser Phe 
                165                 170                 175     


Met Leu Tyr Val Ala Leu Glu Ser Glu Asp Asp Thr Leu Ala Tyr Ala 
            180                 185                 190         


<210>  824
<211>  388
<212>  PRT
<213>  Homo Sapiens

<400>  824

Met Met Ser Pro Ser Gln Ala Ser Leu Leu Phe Leu Asn Val Cys Ile 
1               5                   10                  15      


Phe Ile Cys Gly Glu Ala Val Gln Gly Asn Cys Val His His Ser Thr 
            20                  25                  30          


Asp Ser Ser Val Val Asn Ile Val Glu Asp Gly Ser Asn Ala Lys Asp 
        35                  40                  45              


Glu Ser Lys Ser Asn Asp Thr Val Cys Lys Glu Asp Cys Glu Glu Ser 
    50                  55                  60                  


Cys Asp Val Lys Thr Lys Ile Thr Arg Glu Glu Lys His Phe Met Cys 
65                  70                  75                  80  


Arg Asn Leu Gln Asn Ser Ile Val Ser Tyr Thr Arg Ser Thr Lys Lys 
                85                  90                  95      


Leu Leu Arg Asn Met Met Asp Glu Gln Gln Ala Ser Leu Asp Tyr Leu 
            100                 105                 110         


Ser Asn Gln Val Asn Glu Leu Met Asn Arg Val Leu Leu Leu Thr Thr 
        115                 120                 125             


Glu Val Phe Arg Lys Gln Leu Asp Pro Phe Pro His Arg Pro Val Gln 
    130                 135                 140                 


Ser His Gly Leu Asp Cys Thr Asp Ile Lys Asp Thr Ile Gly Ser Val 
145                 150                 155                 160 


Thr Lys Thr Pro Ser Gly Leu Tyr Ile Ile His Pro Glu Gly Ser Ser 
                165                 170                 175     


Tyr Pro Phe Glu Val Met Cys Asp Met Asp Tyr Arg Gly Gly Gly Arg 
            180                 185                 190         


Thr Val Ile Gln Lys Arg Ile Asp Gly Ile Ile Asp Phe Gln Arg Leu 
        195                 200                 205             


Trp Cys Asp Tyr Leu Asp Gly Phe Gly Asp Leu Leu Gly Glu Phe Trp 
    210                 215                 220                 


Leu Gly Leu Lys Lys Ile Phe Tyr Ile Val Asn Gln Lys Asn Thr Ser 
225                 230                 235                 240 


Phe Met Leu Tyr Val Ala Leu Glu Ser Glu Asp Asp Thr Leu Ala Tyr 
                245                 250                 255     


Ala Ser Tyr Asp Asn Phe Trp Leu Glu Asp Glu Thr Arg Phe Phe Lys 
            260                 265                 270         


Met His Leu Gly Arg Tyr Ser Gly Asn Ala Gly Asp Ala Phe Arg Gly 
        275                 280                 285             


Leu Lys Lys Glu Asp Asn Gln Asn Ala Met Pro Phe Ser Thr Ser Asp 
    290                 295                 300                 


Val Asp Asn Asp Gly Cys Arg Pro Ala Cys Leu Val Asn Gly Gln Ser 
305                 310                 315                 320 


Val Lys Ser Cys Ser His Leu His Asn Lys Thr Gly Trp Trp Phe Asn 
                325                 330                 335     


Glu Cys Gly Leu Ala Asn Leu Asn Gly Ile His His Phe Ser Gly Lys 
            340                 345                 350         


Leu Leu Ala Thr Gly Ile Gln Trp Gly Thr Trp Thr Lys Asn Asn Ser 
        355                 360                 365             


Pro Val Lys Ile Lys Ser Val Ser Met Lys Ile Arg Arg Met Tyr Asn 
    370                 375                 380                 


Pro Tyr Phe Lys 
385             


<210>  825
<211>  470
<212>  PRT
<213>  Homo Sapiens

<400>  825

Met Gly Lys Pro Trp Leu Arg Ala Leu Gln Leu Leu Leu Leu Leu Gly 
1               5                   10                  15      


Ala Ser Trp Ala Arg Ala Gly Ala Pro Arg Cys Thr Tyr Thr Phe Val 
            20                  25                  30          


Leu Pro Pro Gln Lys Phe Thr Gly Ala Val Cys Trp Ser Gly Pro Ala 
        35                  40                  45              


Ser Thr Arg Ala Thr Pro Glu Ala Ala Asn Ala Ser Glu Leu Ala Ala 
    50                  55                  60                  


Leu Arg Met Arg Val Gly Arg His Glu Glu Leu Leu Arg Glu Leu Gln 
65                  70                  75                  80  


Arg Leu Ala Ala Ala Asp Gly Ala Val Ala Gly Glu Val Arg Ala Leu 
                85                  90                  95      


Arg Lys Glu Ser Arg Gly Leu Ser Ala Arg Leu Gly Gln Leu Arg Ala 
            100                 105                 110         


Gln Leu Gln His Glu Ala Gly Pro Gly Ala Gly Pro Gly Ala Asp Leu 
        115                 120                 125             


Gly Ala Glu Pro Ala Ala Ala Leu Ala Leu Leu Gly Glu Arg Val Leu 
    130                 135                 140                 


Asn Ala Ser Ala Glu Ala Gln Arg Ala Ala Ala Arg Phe His Gln Leu 
145                 150                 155                 160 


Asp Val Lys Phe Arg Glu Leu Ala Gln Leu Val Thr Gln Gln Ser Ser 
                165                 170                 175     


Leu Ile Ala Arg Leu Glu Arg Leu Cys Pro Gly Gly Ala Gly Gly Gln 
            180                 185                 190         


Gln Gln Val Leu Pro Pro Pro Pro Leu Val Pro Val Val Pro Val Arg 
        195                 200                 205             


Leu Val Gly Ser Thr Ser Asp Thr Ser Arg Met Leu Asp Pro Ala Pro 
    210                 215                 220                 


Glu Pro Gln Arg Asp Gln Thr Gln Arg Gln Gln Glu Pro Met Ala Ser 
225                 230                 235                 240 


Pro Met Pro Ala Gly His Pro Ala Val Pro Thr Lys Pro Val Gly Pro 
                245                 250                 255     


Trp Gln Asp Cys Ala Glu Ala Arg Gln Ala Gly His Glu Gln Ser Gly 
            260                 265                 270         


Val Tyr Glu Leu Arg Val Gly Arg His Val Val Ser Val Trp Cys Glu 
        275                 280                 285             


Gln Gln Leu Glu Gly Gly Gly Trp Thr Val Ile Gln Arg Arg Gln Asp 
    290                 295                 300                 


Gly Ser Val Asn Phe Phe Thr Thr Trp Gln His Tyr Lys Ala Gly Phe 
305                 310                 315                 320 


Gly Arg Pro Asp Gly Glu Tyr Trp Leu Gly Leu Glu Pro Val Tyr Gln 
                325                 330                 335     


Leu Thr Ser Arg Gly Asp His Glu Leu Leu Val Leu Leu Glu Asp Trp 
            340                 345                 350         


Gly Gly Arg Gly Ala Arg Ala His Tyr Asp Gly Phe Ser Leu Glu Pro 
        355                 360                 365             


Glu Ser Asp His Tyr Arg Leu Arg Leu Gly Gln Tyr His Gly Asp Ala 
    370                 375                 380                 


Gly Asp Ser Leu Ser Trp His Asn Asp Lys Pro Phe Ser Thr Val Asp 
385                 390                 395                 400 


Arg Asp Arg Asp Ser Tyr Ser Gly Asn Cys Ala Leu Tyr Gln Arg Gly 
                405                 410                 415     


Gly Trp Trp Tyr His Ala Cys Ala His Ser Asn Leu Asn Gly Val Trp 
            420                 425                 430         


His His Gly Gly His Tyr Arg Ser Arg Tyr Gln Asp Gly Val Tyr Trp 
        435                 440                 445             


Ala Glu Phe Arg Gly Gly Ala Tyr Ser Leu Arg Lys Ala Ala Met Leu 
    450                 455                 460                 


Ile Arg Pro Leu Lys Leu 
465                 470 


<210>  826
<211>  470
<212>  PRT
<213>  Homo Sapiens

<400>  826

Met Gly Lys Pro Trp Leu Arg Ala Leu Gln Leu Leu Leu Leu Leu Gly 
1               5                   10                  15      


Ala Ser Trp Ala Arg Ala Gly Ala Pro Arg Cys Thr Tyr Thr Phe Val 
            20                  25                  30          


Leu Pro Pro Gln Lys Phe Thr Gly Ala Val Cys Trp Ser Gly Pro Ala 
        35                  40                  45              


Ser Thr Arg Ala Thr Pro Glu Ala Ala Asn Ala Ser Glu Leu Ala Ala 
    50                  55                  60                  


Leu Arg Met Arg Val Gly Arg His Glu Glu Leu Leu Arg Glu Leu Gln 
65                  70                  75                  80  


Arg Leu Ala Ala Ala Asp Gly Ala Val Ala Gly Glu Val Arg Ala Leu 
                85                  90                  95      


Arg Lys Glu Ser Arg Gly Leu Ser Ala Arg Leu Gly Gln Leu Arg Ala 
            100                 105                 110         


Gln Leu Gln His Glu Ala Gly Pro Gly Ala Gly Pro Gly Ala Asp Leu 
        115                 120                 125             


Gly Ala Glu Pro Ala Ala Ala Leu Ala Leu Leu Gly Glu Arg Val Leu 
    130                 135                 140                 


Asn Ala Ser Ala Glu Ala Gln Arg Ala Ala Ala Arg Phe His Gln Leu 
145                 150                 155                 160 


Asp Val Lys Phe Arg Glu Leu Ala Gln Leu Val Thr Gln Gln Ser Ser 
                165                 170                 175     


Leu Ile Ala Arg Leu Glu Arg Leu Cys Pro Gly Gly Ala Gly Gly Gln 
            180                 185                 190         


Gln Gln Val Leu Pro Pro Pro Pro Leu Val Pro Val Val Pro Val Arg 
        195                 200                 205             


Leu Val Gly Ser Thr Ser Asp Thr Ser Arg Met Leu Asp Pro Ala Pro 
    210                 215                 220                 


Glu Pro Gln Arg Asp Gln Thr Gln Arg Gln Gln Glu Pro Met Ala Ser 
225                 230                 235                 240 


Pro Met Pro Ala Gly His Pro Ala Val Pro Thr Lys Pro Val Gly Pro 
                245                 250                 255     


Trp Gln Asp Cys Ala Glu Ala Arg Gln Ala Gly His Glu Gln Ser Gly 
            260                 265                 270         


Val Tyr Glu Leu Arg Val Gly Arg His Val Val Ser Val Trp Cys Glu 
        275                 280                 285             


Gln Gln Leu Glu Gly Gly Gly Trp Thr Val Ile Gln Arg Arg Gln Asp 
    290                 295                 300                 


Gly Ser Val Asn Phe Phe Thr Thr Trp Gln His Tyr Lys Ala Gly Phe 
305                 310                 315                 320 


Gly Arg Pro Asp Gly Glu Tyr Trp Leu Gly Leu Glu Pro Val Tyr Gln 
                325                 330                 335     


Leu Thr Ser Arg Gly Asp His Glu Leu Leu Val Leu Leu Glu Asp Trp 
            340                 345                 350         


Gly Gly Arg Gly Ala Arg Ala His Tyr Asp Gly Phe Ser Leu Glu Pro 
        355                 360                 365             


Glu Ser Asp His Tyr Arg Leu Arg Leu Gly Gln Tyr His Gly Asp Ala 
    370                 375                 380                 


Gly Asp Ser Leu Ser Trp His Asn Asp Lys Pro Phe Ser Thr Val Asp 
385                 390                 395                 400 


Arg Asp Arg Asp Ser Tyr Ser Gly Asn Cys Ala Leu Tyr Gln Arg Gly 
                405                 410                 415     


Gly Trp Trp Tyr His Ala Cys Ala His Ser Asn Leu Asn Gly Val Trp 
            420                 425                 430         


His His Gly Gly His Tyr Arg Ser Arg Tyr Gln Asp Gly Val Tyr Trp 
        435                 440                 445             


Ala Glu Phe Arg Gly Gly Ala Tyr Ser Leu Arg Lys Ala Ala Met Leu 
    450                 455                 460                 


Ile Arg Pro Leu Lys Leu 
465                 470 


<210>  827
<211>  430
<212>  PRT
<213>  Homo Sapiens

<400>  827

Met Gly Lys Pro Trp Leu Arg Ala Leu Gln Leu Leu Leu Leu Leu Gly 
1               5                   10                  15      


Ala Ser Trp Ala Arg Ala Gly Ala Pro Arg Cys Thr Tyr Thr Phe Val 
            20                  25                  30          


Leu Pro Pro Gln Lys Phe Thr Gly Ala Val Cys Trp Ser Gly Pro Ala 
        35                  40                  45              


Ser Thr Arg Ala Thr Pro Glu Ala Ala Asn Ala Ser Glu Leu Ala Ala 
    50                  55                  60                  


Leu Arg Met Arg Val Gly Arg His Glu Glu Leu Leu Arg Glu Leu Gln 
65                  70                  75                  80  


Arg Leu Ala Ala Ala Asp Gly Ala Val Ala Gly Glu Val Arg Ala Leu 
                85                  90                  95      


Arg Lys Glu Ser Arg Gly Leu Ser Ala Arg Leu Gly Gln Leu Arg Ala 
            100                 105                 110         


Gln Leu Gln His Glu Ala Gly Pro Gly Ala Gly Pro Gly Ala Asp Leu 
        115                 120                 125             


Gly Ala Glu Pro Ala Ala Ala Leu Ala Leu Leu Gly Glu Arg Val Leu 
    130                 135                 140                 


Asn Ala Ser Ala Glu Ala Gln Arg Ala Ala Ala Arg Phe His Gln Leu 
145                 150                 155                 160 


Asp Val Lys Phe Arg Glu Leu Ala Gln Leu Val Thr Gln Gln Ser Ser 
                165                 170                 175     


Leu Ile Ala Arg Leu Glu Arg Leu Cys Pro Gly Gly Ala Gly Gly Gln 
            180                 185                 190         


Gln Gln Val Leu Pro Pro Pro Pro Leu Val Pro Val Val Pro Val Arg 
        195                 200                 205             


Leu Val Gly Ser Thr Ser Asp Thr Ser Arg Met Leu Asp Pro Ala Pro 
    210                 215                 220                 


Glu Pro Gln Arg Asp Gln Thr Gln Arg Gln Gln Glu Pro Met Ala Ser 
225                 230                 235                 240 


Pro Met Pro Ala Gly His Pro Ala Val Pro Thr Lys Pro Val Gly Pro 
                245                 250                 255     


Trp Gln Asp Cys Ala Glu Ala Arg Gln Ala Gly His Glu Gln Ser Gly 
            260                 265                 270         


Val Tyr Glu Leu Arg Ala Gly Phe Gly Arg Pro Asp Gly Glu Tyr Trp 
        275                 280                 285             


Leu Gly Leu Glu Pro Val Tyr Gln Leu Thr Ser Arg Gly Asp His Glu 
    290                 295                 300                 


Leu Leu Val Leu Leu Glu Asp Trp Gly Gly Arg Gly Ala Arg Ala His 
305                 310                 315                 320 


Tyr Asp Gly Phe Ser Leu Glu Pro Glu Ser Asp His Tyr Arg Leu Arg 
                325                 330                 335     


Leu Gly Gln Tyr His Gly Asp Ala Gly Asp Ser Leu Ser Trp His Asn 
            340                 345                 350         


Asp Lys Pro Phe Ser Thr Val Asp Arg Asp Arg Asp Ser Tyr Ser Gly 
        355                 360                 365             


Asn Cys Ala Leu Tyr Gln Arg Gly Gly Trp Trp Tyr His Ala Cys Ala 
    370                 375                 380                 


His Ser Asn Leu Asn Gly Val Trp His His Gly Gly His Tyr Arg Ser 
385                 390                 395                 400 


Arg Tyr Gln Asp Gly Val Tyr Trp Ala Glu Phe Arg Gly Gly Ala Tyr 
                405                 410                 415     


Ser Leu Arg Lys Ala Ala Met Leu Ile Arg Pro Leu Lys Leu 
            420                 425                 430 


<210>  828
<211>  346
<212>  PRT
<213>  Homo Sapiens

<400>  828

Met Leu Lys Lys Pro Leu Ser Ala Val Thr Trp Leu Cys Ile Phe Ile 
1               5                   10                  15      


Val Ala Phe Val Ser His Pro Ala Trp Leu Gln Lys Leu Ser Lys His 
            20                  25                  30          


Lys Thr Pro Ala Gln Pro Gln Leu Lys Ala Ala Asn Cys Cys Glu Glu 
        35                  40                  45              


Val Lys Glu Leu Lys Ala Gln Val Ala Asn Leu Ser Ser Leu Leu Ser 
    50                  55                  60                  


Glu Leu Asn Lys Lys Gln Glu Arg Asp Trp Val Ser Val Val Met Gln 
65                  70                  75                  80  


Val Met Glu Leu Glu Ser Asn Ser Lys Arg Met Glu Ser Arg Leu Thr 
                85                  90                  95      


Asp Ala Glu Ser Lys Tyr Ser Glu Met Asn Asn Gln Ile Asp Ile Met 
            100                 105                 110         


Gln Leu Gln Ala Ala Gln Thr Val Thr Gln Thr Ser Ala Asp Ala Ile 
        115                 120                 125             


Tyr Asp Cys Ser Ser Leu Tyr Gln Lys Asn Tyr Arg Ile Ser Gly Val 
    130                 135                 140                 


Tyr Lys Leu Pro Pro Asp Asp Phe Leu Gly Ser Pro Glu Leu Glu Val 
145                 150                 155                 160 


Phe Cys Asp Met Glu Thr Ser Gly Gly Gly Trp Thr Ile Ile Gln Arg 
                165                 170                 175     


Arg Lys Ser Gly Leu Val Ser Phe Tyr Arg Asp Trp Lys Gln Tyr Lys 
            180                 185                 190         


Gln Gly Phe Gly Ser Ile Arg Gly Asp Phe Trp Leu Gly Asn Glu His 
        195                 200                 205             


Ile His Arg Leu Ser Arg Gln Pro Thr Arg Leu Arg Val Glu Met Glu 
    210                 215                 220                 


Asp Trp Glu Gly Asn Leu Arg Tyr Ala Glu Tyr Ser His Phe Val Leu 
225                 230                 235                 240 


Gly Asn Glu Leu Asn Ser Tyr Arg Leu Phe Leu Gly Asn Tyr Thr Gly 
                245                 250                 255     


Asn Val Gly Asn Asp Ala Leu Gln Tyr His Asn Asn Thr Ala Phe Ser 
            260                 265                 270         


Thr Lys Asp Lys Asp Asn Asp Asn Cys Leu Asp Lys Cys Ala Gln Leu 
        275                 280                 285             


Arg Lys Gly Gly Tyr Trp Tyr Asn Cys Cys Thr Asp Ser Asn Leu Asn 
    290                 295                 300                 


Gly Val Tyr Tyr Arg Leu Gly Glu His Asn Lys His Leu Asp Gly Ile 
305                 310                 315                 320 


Thr Trp Tyr Gly Trp His Gly Ser Thr Tyr Ser Leu Lys Arg Val Glu 
                325                 330                 335     


Met Lys Ile Arg Pro Glu Asp Phe Lys Pro 
            340                 345     


<210>  829
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  829

Met Glu Glu Asp Ile Leu Gln Leu Gln Ala Glu Ala Thr Ala Glu Val 
1               5                   10                  15      


Leu Gly Glu Val Ala Gln Ala Gln Lys Val Leu Arg Asp Ser Val Gln 
            20                  25                  30          


Arg Leu Glu Val Gln Leu Arg Ser Ala Trp Leu Gly Pro Ala Tyr Arg 
        35                  40                  45              


Glu Phe Glu Val Leu Lys Ala His Ala Asp Lys Gln Ser His Ile Leu 
    50                  55                  60                  


Trp Ala Leu Thr Gly His Val Gln Arg Gln Arg Arg Glu Met Val Ala 
65                  70                  75                  80  


Gln Gln His Arg Leu Arg Gln Ile Gln Glu Arg Leu His Thr Ala Ala 
                85                  90                  95      


Leu Pro Ala 
            


<210>  830
<211>  198
<212>  PRT
<213>  Homo Sapiens

<400>  830

Met Pro Val Pro Ala Leu Cys Leu Leu Trp Ala Leu Ala Met Val Thr 
1               5                   10                  15      


Arg Pro Ala Ser Ala Ala Pro Met Gly Gly Pro Glu Leu Ala Gln His 
            20                  25                  30          


Glu Glu Leu Thr Leu Leu Phe His Gly Thr Leu Gln Leu Gly Gln Ala 
        35                  40                  45              


Leu Asn Gly Val Tyr Arg Thr Thr Glu Gly Arg Leu Thr Lys Ala Arg 
    50                  55                  60                  


Asn Ser Leu Gly Leu Tyr Gly Arg Thr Ile Glu Leu Leu Gly Gln Glu 
65                  70                  75                  80  


Val Ser Arg Gly Arg Asp Ala Ala Gln Glu Leu Arg Ala Ser Leu Leu 
                85                  90                  95      


Glu Thr Gln Met Glu Glu Asp Ile Leu Gln Leu Gln Ala Glu Ala Thr 
            100                 105                 110         


Ala Glu Val Leu Gly Glu Val Ala Gln Ala Gln Lys Val Leu Arg Asp 
        115                 120                 125             


Ser Val Gln Arg Leu Glu Val Gln Leu Arg Ser Ala Trp Leu Gly Pro 
    130                 135                 140                 


Ala Tyr Arg Glu Phe Glu Val Leu Lys Ala His Ala Asp Lys Gln Ser 
145                 150                 155                 160 


His Ile Leu Trp Ala Leu Thr Gly His Val Gln Arg Gln Arg Arg Glu 
                165                 170                 175     


Met Val Ala Gln Gln His Arg Leu Arg Gln Ile Gln Glu Arg Leu His 
            180                 185                 190         


Thr Ala Ala Leu Pro Ala 
        195             


<210>  831
<211>  198
<212>  PRT
<213>  Homo Sapiens

<400>  831

Met Pro Val Pro Ala Leu Cys Leu Leu Trp Ala Leu Ala Met Val Thr 
1               5                   10                  15      


Arg Pro Ala Ser Ala Ala Pro Met Gly Gly Pro Glu Leu Ala Gln His 
            20                  25                  30          


Glu Glu Leu Thr Leu Leu Phe His Gly Thr Leu Gln Leu Gly Gln Ala 
        35                  40                  45              


Leu Asn Gly Val Tyr Arg Thr Thr Glu Gly Arg Leu Thr Lys Ala Arg 
    50                  55                  60                  


Asn Ser Leu Gly Leu Tyr Gly Arg Thr Ile Glu Leu Leu Gly Gln Glu 
65                  70                  75                  80  


Val Ser Arg Gly Arg Asp Ala Ala Gln Glu Leu Arg Ala Ser Leu Leu 
                85                  90                  95      


Glu Thr Gln Met Glu Glu Asp Ile Leu Gln Leu Gln Ala Glu Ala Thr 
            100                 105                 110         


Ala Glu Val Leu Gly Glu Val Ala Gln Ala Gln Lys Val Leu Arg Asp 
        115                 120                 125             


Ser Val Gln Arg Leu Glu Val Gln Leu Arg Ser Ala Trp Leu Gly Pro 
    130                 135                 140                 


Ala Tyr Arg Glu Phe Glu Val Leu Lys Ala His Ala Asp Lys Gln Ser 
145                 150                 155                 160 


His Ile Leu Trp Ala Leu Thr Gly His Val Gln Arg Gln Arg Arg Glu 
                165                 170                 175     


Met Val Ala Gln Gln His Arg Leu Arg Gln Ile Gln Glu Arg Leu His 
            180                 185                 190         


Thr Ala Ala Leu Pro Ala 
        195             


<210>  832
<211>  58
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  832

Xaa Ala Gln Glu Leu Arg Ala Ser Leu Leu Glu Thr Gln Ala His Ala 
1               5                   10                  15      


Asp Lys Gln Ser His Ile Leu Trp Ala Leu Thr Gly His Val Gln Arg 
            20                  25                  30          


Gln Arg Arg Glu Met Val Ala Gln Gln His Arg Leu Arg Gln Ile Gln 
        35                  40                  45              


Glu Arg Leu His Thr Ala Ala Leu Pro Ala 
    50                  55              


<210>  833
<211>  1897
<212>  PRT
<213>  Homo Sapiens

<400>  833

Met Ala Gln Ala Ala Lys Gln Leu Lys Lys Ile Lys Asp Ile Glu Ala 
1               5                   10                  15      


Gln Ala Leu Gln Glu Gln Lys Glu Lys Glu Glu Ser Asn Arg Lys Arg 
            20                  25                  30          


Arg Asn Arg Ser Arg Asp Arg Lys Lys Lys Ala Asp Ala Ala Thr Ser 
        35                  40                  45              


Phe Leu Arg Ala Ala Arg Ser Gly Asn Leu Asp Lys Ala Leu Asp His 
    50                  55                  60                  


Leu Arg Asn Gly Val Asp Ile Asn Thr Cys Asn Gln Asn Gly Leu Asn 
65                  70                  75                  80  


Gly Leu His Leu Ala Ser Lys Glu Gly His Val Lys Met Val Val Glu 
                85                  90                  95      


Leu Leu His Lys Glu Ile Ile Leu Glu Thr Thr Thr Lys Lys Gly Asn 
            100                 105                 110         


Thr Ala Leu His Ile Ala Ala Leu Ala Gly Gln Asp Glu Val Val Arg 
        115                 120                 125             


Glu Leu Val Asn Tyr Gly Ala Asn Val Asn Ala Gln Ser Gln Lys Gly 
    130                 135                 140                 


Phe Thr Pro Leu Tyr Met Ala Ala Gln Glu Asn His Leu Glu Val Val 
145                 150                 155                 160 


Lys Phe Leu Leu Glu Asn Gly Ala Asn Gln Asn Val Ala Thr Glu Asp 
                165                 170                 175     


Gly Phe Thr Pro Leu Ala Val Ala Leu Gln Gln Gly His Glu Asn Val 
            180                 185                 190         


Val Ala His Leu Ile Asn Tyr Gly Thr Lys Gly Lys Val Arg Leu Pro 
        195                 200                 205             


Ala Leu His Ile Ala Ala Arg Asn Asp Asp Thr Arg Thr Ala Ala Val 
    210                 215                 220                 


Leu Leu Gln Asn Asp Pro Asn Pro Asp Val Leu Ser Lys Thr Gly Phe 
225                 230                 235                 240 


Thr Pro Leu His Ile Ala Ala His Tyr Glu Asn Leu Asn Val Ala Gln 
                245                 250                 255     


Leu Leu Leu Asn Arg Gly Ala Ser Val Asn Phe Thr Pro Gln Asn Gly 
            260                 265                 270         


Ile Thr Pro Leu His Ile Ala Ser Arg Arg Gly Asn Val Ile Met Val 
        275                 280                 285             


Arg Leu Leu Leu Asp Arg Gly Ala Gln Ile Glu Thr Lys Thr Lys Asp 
    290                 295                 300                 


Glu Leu Thr Pro Leu His Cys Ala Ala Arg Asn Gly His Val Arg Ile 
305                 310                 315                 320 


Ser Glu Ile Leu Leu Asp His Gly Ala Pro Ile Gln Ala Lys Thr Lys 
                325                 330                 335     


Asn Gly Leu Ser Pro Ile His Met Ala Ala Gln Gly Asp His Leu Asp 
            340                 345                 350         


Cys Val Arg Leu Leu Leu Gln Tyr Asp Ala Glu Ile Asp Asp Ile Thr 
        355                 360                 365             


Leu Asp His Leu Thr Pro Leu His Val Ala Ala His Cys Gly His His 
    370                 375                 380                 


Arg Val Ala Lys Val Leu Leu Asp Lys Gly Ala Lys Pro Asn Ser Arg 
385                 390                 395                 400 


Ala Leu Asn Gly Phe Thr Pro Leu His Ile Ala Cys Lys Lys Asn His 
                405                 410                 415     


Val Arg Val Met Glu Leu Leu Leu Lys Thr Gly Ala Ser Ile Asp Ala 
            420                 425                 430         


Val Thr Glu Ser Gly Leu Thr Pro Leu His Val Ala Ser Phe Met Gly 
        435                 440                 445             


His Leu Pro Ile Val Lys Asn Leu Leu Gln Arg Gly Ala Ser Pro Asn 
    450                 455                 460                 


Val Ser Asn Val Lys Val Glu Thr Pro Leu His Met Ala Ala Arg Ala 
465                 470                 475                 480 


Gly His Thr Glu Val Ala Lys Tyr Leu Leu Gln Asn Lys Ala Lys Val 
                485                 490                 495     


Asn Ala Lys Ala Lys Asp Asp Gln Thr Pro Leu His Cys Ala Ala Arg 
            500                 505                 510         


Ile Gly His Thr Asn Met Val Lys Leu Leu Leu Glu Asn Asn Ala Asn 
        515                 520                 525             


Pro Asn Leu Ala Thr Thr Ala Gly His Thr Pro Leu His Ile Ala Ala 
    530                 535                 540                 


Arg Glu Gly His Val Glu Thr Val Leu Ala Leu Leu Glu Lys Glu Ala 
545                 550                 555                 560 


Ser Gln Ala Cys Met Thr Lys Lys Gly Phe Thr Pro Leu His Val Ala 
                565                 570                 575     


Ala Lys Tyr Gly Lys Val Arg Val Ala Glu Leu Leu Leu Glu Arg Asp 
            580                 585                 590         


Ala His Pro Asn Ala Ala Gly Lys Asn Gly Leu Thr Pro Leu His Val 
        595                 600                 605             


Ala Val His His Asn Asn Leu Asp Ile Val Lys Leu Leu Leu Pro Arg 
    610                 615                 620                 


Gly Gly Ser Pro His Ser Pro Ala Trp Asn Gly Tyr Thr Pro Leu His 
625                 630                 635                 640 


Ile Ala Ala Lys Gln Asn Gln Val Glu Val Ala Arg Ser Leu Leu Gln 
                645                 650                 655     


Tyr Gly Gly Ser Ala Asn Ala Glu Ser Val Gln Gly Val Thr Pro Leu 
            660                 665                 670         


His Leu Ala Ala Gln Glu Gly His Ala Glu Met Val Ala Leu Leu Leu 
        675                 680                 685             


Ser Lys Gln Ala Asn Gly Asn Leu Gly Asn Lys Ser Gly Leu Thr Pro 
    690                 695                 700                 


Leu His Leu Val Ala Gln Glu Gly His Val Pro Val Ala Asp Val Leu 
705                 710                 715                 720 


Ile Lys His Gly Val Met Val Asp Ala Thr Thr Arg Met Gly Tyr Thr 
                725                 730                 735     


Pro Leu His Val Ala Ser His Tyr Gly Asn Ile Lys Leu Val Lys Phe 
            740                 745                 750         


Leu Leu Gln His Gln Ala Asp Val Asn Ala Lys Thr Lys Leu Gly Tyr 
        755                 760                 765             


Ser Pro Leu His Gln Ala Ala Gln Gln Gly His Thr Asp Ile Val Thr 
    770                 775                 780                 


Leu Leu Leu Lys Asn Gly Ala Ser Pro Asn Glu Val Ser Ser Asp Gly 
785                 790                 795                 800 


Thr Thr Pro Leu Ala Ile Ala Lys Arg Leu Gly Tyr Ile Ser Val Thr 
                805                 810                 815     


Asp Val Leu Lys Val Val Thr Asp Glu Thr Ser Phe Val Leu Val Ser 
            820                 825                 830         


Asp Lys His Arg Met Ser Phe Pro Glu Thr Val Asp Glu Ile Leu Asp 
        835                 840                 845             


Val Ser Glu Asp Glu Gly Thr Ala His Ile Thr Ile Met Gly Glu Glu 
    850                 855                 860                 


Leu Ile Ser Phe Lys Ala Glu Arg Arg Asp Ser Arg Asp Val Asp Glu 
865                 870                 875                 880 


Glu Lys Glu Leu Leu Asp Phe Val Pro Lys Leu Asp Gln Val Val Glu 
                885                 890                 895     


Ser Pro Ala Ile Pro Arg Ile Pro Cys Ala Met Pro Glu Thr Val Val 
            900                 905                 910         


Ile Arg Ser Glu Glu Gln Glu Gln Ala Ser Lys Glu Tyr Asp Glu Asp 
        915                 920                 925             


Ser Leu Ile Pro Ser Ser Pro Ala Thr Glu Thr Ser Asp Asn Ile Ser 
    930                 935                 940                 


Pro Val Ala Ser Pro Val His Thr Gly Phe Leu Val Ser Phe Met Val 
945                 950                 955                 960 


Asp Ala Arg Gly Gly Ser Met Arg Gly Ser Arg His Asn Gly Leu Arg 
                965                 970                 975     


Val Val Ile Pro Pro Arg Thr Cys Ala Ala Pro Thr Arg Ile Thr Cys 
            980                 985                 990         


Arg Leu Val Lys Pro Gln Lys Leu  Ser Thr Pro Pro Pro  Leu Ala Glu 
        995                 1000                 1005             


Glu Glu  Gly Leu Ala Ser Arg  Ile Ile Ala Leu Gly  Pro Thr Gly 
    1010                 1015                 1020             


Ala Gln  Phe Leu Ser Pro Val  Ile Val Glu Ile Pro  His Phe Ala 
    1025                 1030                 1035             


Ser His  Gly Arg Gly Asp Arg  Glu Leu Val Val Leu  Arg Ser Glu 
    1040                 1045                 1050             


Asn Gly  Ser Val Trp Lys Glu  His Arg Ser Arg Tyr  Gly Glu Ser 
    1055                 1060                 1065             


Tyr Leu  Asp Gln Ile Leu Asn  Gly Met Asp Glu Glu  Leu Gly Ser 
    1070                 1075                 1080             


Leu Glu  Glu Leu Glu Lys Lys  Arg Val Cys Arg Ile  Ile Thr Thr 
    1085                 1090                 1095             


Asp Phe  Pro Leu Tyr Phe Val  Ile Met Ser Arg Leu  Cys Gln Asp 
    1100                 1105                 1110             


Tyr Asp  Thr Ile Gly Pro Glu  Gly Gly Ser Leu Lys  Ser Lys Leu 
    1115                 1120                 1125             


Val Pro  Leu Val Gln Ala Thr  Phe Pro Glu Asn Ala  Val Thr Lys 
    1130                 1135                 1140             


Arg Val  Lys Leu Ala Leu Gln  Ala Gln Pro Val Pro  Asp Glu Leu 
    1145                 1150                 1155             


Val Thr  Lys Leu Leu Gly Asn  Gln Ala Thr Phe Ser  Pro Ile Val 
    1160                 1165                 1170             


Thr Val  Glu Pro Arg Arg Arg  Lys Phe His Arg Pro  Ile Gly Leu 
    1175                 1180                 1185             


Arg Ile  Pro Leu Pro Pro Ser  Trp Thr Asp Asn Pro  Arg Asp Ser 
    1190                 1195                 1200             


Gly Glu  Gly Asp Thr Thr Ser  Leu Arg Leu Leu Cys  Ser Val Ile 
    1205                 1210                 1215             


Gly Gly  Thr Asp Gln Ala Gln  Trp Glu Asp Ile Thr  Gly Thr Thr 
    1220                 1225                 1230             


Lys Leu  Val Tyr Ala Asn Glu  Cys Ala Asn Phe Thr  Thr Asn Val 
    1235                 1240                 1245             


Ser Ala  Arg Phe Trp Leu Ser  Asp Cys Pro Arg Thr  Ala Glu Ala 
    1250                 1255                 1260             


Val Asn  Phe Ala Thr Leu Leu  Tyr Lys Glu Leu Thr  Ala Val Pro 
    1265                 1270                 1275             


Tyr Met  Ala Lys Phe Val Ile  Phe Ala Lys Met Asn  Asp Pro Arg 
    1280                 1285                 1290             


Glu Gly  Arg Leu Arg Cys Tyr  Cys Met Thr Asp Asp  Lys Val Asp 
    1295                 1300                 1305             


Lys Thr  Leu Glu Gln His Glu  Asn Phe Val Glu Val  Ala Arg Ser 
    1310                 1315                 1320             


Arg Asp  Ile Glu Val Leu Glu  Gly Met Ser Leu Phe  Ala Glu Leu 
    1325                 1330                 1335             


Ser Gly  Asn Leu Val Pro Val  Lys Lys Ala Ala Gln  Gln Arg Ser 
    1340                 1345                 1350             


Phe His  Phe Gln Ser Phe Arg  Glu Asn Arg Leu Ala  Met Pro Val 
    1355                 1360                 1365             


Lys Val  Arg Asp Ser Ser Arg  Glu Pro Gly Gly Ser  Leu Ser Phe 
    1370                 1375                 1380             


Leu Arg  Lys Ala Met Lys Tyr  Glu Asp Thr Gln His  Ile Leu Cys 
    1385                 1390                 1395             


His Leu  Asn Ile Thr Met Pro  Pro Cys Ala Lys Gly  Ser Gly Ala 
    1400                 1405                 1410             


Glu Asp  Arg Arg Arg Thr Pro  Thr Pro Leu Ala Leu  Arg Tyr Ser 
    1415                 1420                 1425             


Ile Leu  Ser Glu Ser Thr Pro  Gly Ser Leu Ser Gly  Thr Glu Gln 
    1430                 1435                 1440             


Ala Glu  Met Lys Met Ala Val  Ile Ser Glu His Leu  Gly Leu Ser 
    1445                 1450                 1455             


Trp Ala  Glu Leu Ala Arg Glu  Leu Gln Phe Ser Val  Glu Asp Ile 
    1460                 1465                 1470             


Asn Arg  Ile Arg Val Glu Asn  Pro Asn Ser Leu Leu  Glu Gln Ser 
    1475                 1480                 1485             


Val Ala  Leu Leu Asn Leu Trp  Val Ile Arg Glu Gly  Gln Asn Ala 
    1490                 1495                 1500             


Asn Met  Glu Asn Leu Tyr Thr  Ala Leu Gln Ser Ile  Asp Arg Gly 
    1505                 1510                 1515             


Glu Ile  Val Asn Met Leu Glu  Gly Ser Gly Arg Gln  Ser Arg Asn 
    1520                 1525                 1530             


Leu Lys  Pro Asp Arg Arg His  Thr Asp Arg Asp Tyr  Ser Leu Ser 
    1535                 1540                 1545             


Pro Ser  Gln Met Asn Gly Tyr  Ser Ser Leu Gln Asp  Glu Leu Leu 
    1550                 1555                 1560             


Ser Pro  Ala Ser Leu Gly Cys  Ala Leu Ser Ser Pro  Leu Arg Ala 
    1565                 1570                 1575             


Asp Gln  Tyr Trp Asn Glu Val  Ala Val Leu Asp Ala  Ile Pro Leu 
    1580                 1585                 1590             


Ala Ala  Thr Glu His Asp Thr  Met Leu Glu Met Ser  Asp Met Gln 
    1595                 1600                 1605             


Val Trp  Ser Ala Gly Leu Thr  Pro Ser Leu Val Thr  Ala Glu Asp 
    1610                 1615                 1620             


Ser Ser  Leu Glu Cys Ser Lys  Ala Glu Asp Ser Asp  Ala Thr Gly 
    1625                 1630                 1635             


His Glu  Trp Lys Leu Glu Gly  Ala Leu Ser Glu Glu  Pro Arg Gly 
    1640                 1645                 1650             


Pro Glu  Leu Gly Ser Leu Glu  Leu Val Glu Asp Asp  Thr Val Asp 
    1655                 1660                 1665             


Ser Asp  Ala Thr Asn Gly Leu  Ile Asp Leu Leu Glu  Gln Glu Glu 
    1670                 1675                 1680             


Gly Gln  Arg Ser Glu Glu Lys  Leu Pro Gly Ser Lys  Arg Gln Asp 
    1685                 1690                 1695             


Asp Ala  Thr Gly Ala Gly Gln  Asp Ser Glu Asn Glu  Val Ser Leu 
    1700                 1705                 1710             


Val Ser  Gly His Gln Arg Gly  Gln Ala Arg Ile Thr  His Ser Pro 
    1715                 1720                 1725             


Thr Val  Ser Gln Val Thr Glu  Arg Ser Gln Asp Arg  Leu Gln Asp 
    1730                 1735                 1740             


Trp Asp  Ala Asp Gly Ser Ile  Val Ser Tyr Leu Gln  Asp Ala Ala 
    1745                 1750                 1755             


Gln Gly  Ser Trp Gln Glu Glu  Val Thr Gln Gly Pro  His Ser Phe 
    1760                 1765                 1770             


Gln Gly  Thr Ser Thr Met Thr  Glu Gly Leu Glu Pro  Gly Gly Ser 
    1775                 1780                 1785             


Gln Glu  Tyr Glu Lys Val Leu  Val Ser Val Ser Glu  His Thr Trp 
    1790                 1795                 1800             


Thr Glu  Gln Pro Glu Ala Glu  Ser Ser Gln Ala Asp  Arg Asp Arg 
    1805                 1810                 1815             


Arg Gln  Gln Gly Gln Glu Glu  Gln Val Gln Glu Ala  Lys Asn Thr 
    1820                 1825                 1830             


Phe Thr  Gln Val Val Gln Gly  Asn Glu Phe Gln Asn  Ile Pro Gly 
    1835                 1840                 1845             


Glu Gln  Val Thr Glu Glu Gln  Phe Thr Asp Glu Gln  Gly Asn Ile 
    1850                 1855                 1860             


Val Thr  Lys Lys Ile Ile Arg  Lys Val Val Arg Gln  Ile Asp Leu 
    1865                 1870                 1875             


Ser Ser  Ala Asp Ala Ala Gln  Glu His Glu Glu Asp  His Thr Ser 
    1880                 1885                 1890             


Thr Pro  Asn Pro 
    1895         


<210>  834
<211>  1880
<212>  PRT
<213>  Homo Sapiens

<400>  834

Met Pro Tyr Ser Val Gly Phe Arg Glu Ala Asp Ala Ala Thr Ser Phe 
1               5                   10                  15      


Leu Arg Ala Ala Arg Ser Gly Asn Leu Asp Lys Ala Leu Asp His Leu 
            20                  25                  30          


Arg Asn Gly Val Asp Ile Asn Thr Cys Asn Gln Asn Gly Leu Asn Gly 
        35                  40                  45              


Leu His Leu Ala Ser Lys Glu Gly His Val Lys Met Val Val Glu Leu 
    50                  55                  60                  


Leu His Lys Glu Ile Ile Leu Glu Thr Thr Thr Lys Lys Gly Asn Thr 
65                  70                  75                  80  


Ala Leu His Ile Ala Ala Leu Ala Gly Gln Asp Glu Val Val Arg Glu 
                85                  90                  95      


Leu Val Asn Tyr Gly Ala Asn Val Asn Ala Gln Ser Gln Lys Gly Phe 
            100                 105                 110         


Thr Pro Leu Tyr Met Ala Ala Gln Glu Asn His Leu Glu Val Val Lys 
        115                 120                 125             


Phe Leu Leu Glu Asn Gly Ala Asn Gln Asn Val Ala Thr Glu Asp Gly 
    130                 135                 140                 


Phe Thr Pro Leu Ala Val Ala Leu Gln Gln Gly His Glu Asn Val Val 
145                 150                 155                 160 


Ala His Leu Ile Asn Tyr Gly Thr Lys Gly Lys Val Arg Leu Pro Ala 
                165                 170                 175     


Leu His Ile Ala Ala Arg Asn Asp Asp Thr Arg Thr Ala Ala Val Leu 
            180                 185                 190         


Leu Gln Asn Asp Pro Asn Pro Asp Val Leu Ser Lys Thr Gly Phe Thr 
        195                 200                 205             


Pro Leu His Ile Ala Ala His Tyr Glu Asn Leu Asn Val Ala Gln Leu 
    210                 215                 220                 


Leu Leu Asn Arg Gly Ala Ser Val Asn Phe Thr Pro Gln Asn Gly Ile 
225                 230                 235                 240 


Thr Pro Leu His Ile Ala Ser Arg Arg Gly Asn Val Ile Met Val Arg 
                245                 250                 255     


Leu Leu Leu Asp Arg Gly Ala Gln Ile Glu Thr Lys Thr Lys Asp Glu 
            260                 265                 270         


Leu Thr Pro Leu His Cys Ala Ala Arg Asn Gly His Val Arg Ile Ser 
        275                 280                 285             


Glu Ile Leu Leu Asp His Gly Ala Pro Ile Gln Ala Lys Thr Lys Asn 
    290                 295                 300                 


Gly Leu Ser Pro Ile His Met Ala Ala Gln Gly Asp His Leu Asp Cys 
305                 310                 315                 320 


Val Arg Leu Leu Leu Gln Tyr Asp Ala Glu Ile Asp Asp Ile Thr Leu 
                325                 330                 335     


Asp His Leu Thr Pro Leu His Val Ala Ala His Cys Gly His His Arg 
            340                 345                 350         


Val Ala Lys Val Leu Leu Asp Lys Gly Ala Lys Pro Asn Ser Arg Ala 
        355                 360                 365             


Leu Asn Gly Phe Thr Pro Leu His Ile Ala Cys Lys Lys Asn His Val 
    370                 375                 380                 


Arg Val Met Glu Leu Leu Leu Lys Thr Gly Ala Ser Ile Asp Ala Val 
385                 390                 395                 400 


Thr Glu Ser Gly Leu Thr Pro Leu His Val Ala Ser Phe Met Gly His 
                405                 410                 415     


Leu Pro Ile Val Lys Asn Leu Leu Gln Arg Gly Ala Ser Pro Asn Val 
            420                 425                 430         


Ser Asn Val Lys Val Glu Thr Pro Leu His Met Ala Ala Arg Ala Gly 
        435                 440                 445             


His Thr Glu Val Ala Lys Tyr Leu Leu Gln Asn Lys Ala Lys Val Asn 
    450                 455                 460                 


Ala Lys Ala Lys Asp Asp Gln Thr Pro Leu His Cys Ala Ala Arg Ile 
465                 470                 475                 480 


Gly His Thr Asn Met Val Lys Leu Leu Leu Glu Asn Asn Ala Asn Pro 
                485                 490                 495     


Asn Leu Ala Thr Thr Ala Gly His Thr Pro Leu His Ile Ala Ala Arg 
            500                 505                 510         


Glu Gly His Val Glu Thr Val Leu Ala Leu Leu Glu Lys Glu Ala Ser 
        515                 520                 525             


Gln Ala Cys Met Thr Lys Lys Gly Phe Thr Pro Leu His Val Ala Ala 
    530                 535                 540                 


Lys Tyr Gly Lys Val Arg Val Ala Glu Leu Leu Leu Glu Arg Asp Ala 
545                 550                 555                 560 


His Pro Asn Ala Ala Gly Lys Asn Gly Leu Thr Pro Leu His Val Ala 
                565                 570                 575     


Val His His Asn Asn Leu Asp Ile Val Lys Leu Leu Leu Pro Arg Gly 
            580                 585                 590         


Gly Ser Pro His Ser Pro Ala Trp Asn Gly Tyr Thr Pro Leu His Ile 
        595                 600                 605             


Ala Ala Lys Gln Asn Gln Val Glu Val Ala Arg Ser Leu Leu Gln Tyr 
    610                 615                 620                 


Gly Gly Ser Ala Asn Ala Glu Ser Val Gln Gly Val Thr Pro Leu His 
625                 630                 635                 640 


Leu Ala Ala Gln Glu Gly His Ala Glu Met Val Ala Leu Leu Leu Ser 
                645                 650                 655     


Lys Gln Ala Asn Gly Asn Leu Gly Asn Lys Ser Gly Leu Thr Pro Leu 
            660                 665                 670         


His Leu Val Ala Gln Glu Gly His Val Pro Val Ala Asp Val Leu Ile 
        675                 680                 685             


Lys His Gly Val Met Val Asp Ala Thr Thr Arg Met Gly Tyr Thr Pro 
    690                 695                 700                 


Leu His Val Ala Ser His Tyr Gly Asn Ile Lys Leu Val Lys Phe Leu 
705                 710                 715                 720 


Leu Gln His Gln Ala Asp Val Asn Ala Lys Thr Lys Leu Gly Tyr Ser 
                725                 730                 735     


Pro Leu His Gln Ala Ala Gln Gln Gly His Thr Asp Ile Val Thr Leu 
            740                 745                 750         


Leu Leu Lys Asn Gly Ala Ser Pro Asn Glu Val Ser Ser Asp Gly Thr 
        755                 760                 765             


Thr Pro Leu Ala Ile Ala Lys Arg Leu Gly Tyr Ile Ser Val Thr Asp 
    770                 775                 780                 


Val Leu Lys Val Val Thr Asp Glu Thr Ser Phe Val Leu Val Ser Asp 
785                 790                 795                 800 


Lys His Arg Met Ser Phe Pro Glu Thr Val Asp Glu Ile Leu Asp Val 
                805                 810                 815     


Ser Glu Asp Glu Gly Glu Glu Leu Ile Ser Phe Lys Ala Glu Arg Arg 
            820                 825                 830         


Asp Ser Arg Asp Val Asp Glu Glu Lys Glu Leu Leu Asp Phe Val Pro 
        835                 840                 845             


Lys Leu Asp Gln Val Val Glu Ser Pro Ala Ile Pro Arg Ile Pro Cys 
    850                 855                 860                 


Ala Met Pro Glu Thr Val Val Ile Arg Ser Glu Glu Gln Glu Gln Ala 
865                 870                 875                 880 


Ser Lys Glu Tyr Asp Glu Asp Ser Leu Ile Pro Ser Ser Pro Ala Thr 
                885                 890                 895     


Glu Thr Ser Asp Asn Ile Ser Pro Val Ala Ser Pro Val His Thr Gly 
            900                 905                 910         


Phe Leu Val Ser Phe Met Val Asp Ala Arg Gly Gly Ser Met Arg Gly 
        915                 920                 925             


Ser Arg His Asn Gly Leu Arg Val Val Ile Pro Pro Arg Thr Cys Ala 
    930                 935                 940                 


Ala Pro Thr Arg Ile Thr Cys Arg Leu Val Lys Pro Gln Lys Leu Ser 
945                 950                 955                 960 


Thr Pro Pro Pro Leu Ala Glu Glu Glu Gly Leu Ala Ser Arg Ile Ile 
                965                 970                 975     


Ala Leu Gly Pro Thr Gly Ala Gln Phe Leu Ser Pro Val Ile Val Glu 
            980                 985                 990         


Ile Pro His Phe Ala Ser His Gly  Arg Gly Asp Arg Glu  Leu Val Val 
        995                 1000                 1005             


Leu Arg  Ser Glu Asn Gly Ser  Val Trp Lys Glu His  Arg Ser Arg 
    1010                 1015                 1020             


Tyr Gly  Glu Ser Tyr Leu Asp  Gln Ile Leu Asn Gly  Met Asp Glu 
    1025                 1030                 1035             


Glu Leu  Gly Ser Leu Glu Glu  Leu Glu Lys Lys Arg  Val Cys Arg 
    1040                 1045                 1050             


Ile Ile  Thr Thr Asp Phe Pro  Leu Tyr Phe Val Ile  Met Ser Arg 
    1055                 1060                 1065             


Leu Cys  Gln Asp Tyr Asp Thr  Ile Gly Pro Glu Gly  Gly Ser Leu 
    1070                 1075                 1080             


Lys Ser  Lys Leu Val Pro Leu  Val Gln Ala Thr Phe  Pro Glu Asn 
    1085                 1090                 1095             


Ala Val  Thr Lys Arg Val Lys  Leu Ala Leu Gln Ala  Gln Pro Val 
    1100                 1105                 1110             


Pro Asp  Glu Leu Val Thr Lys  Leu Leu Gly Asn Gln  Ala Thr Phe 
    1115                 1120                 1125             


Ser Pro  Ile Val Thr Val Glu  Pro Arg Arg Arg Lys  Phe His Arg 
    1130                 1135                 1140             


Pro Ile  Gly Leu Arg Ile Pro  Leu Pro Pro Ser Trp  Thr Asp Asn 
    1145                 1150                 1155             


Pro Arg  Asp Ser Gly Glu Gly  Asp Thr Thr Ser Leu  Arg Leu Leu 
    1160                 1165                 1170             


Cys Ser  Val Ile Gly Gly Thr  Asp Gln Ala Gln Trp  Glu Asp Ile 
    1175                 1180                 1185             


Thr Gly  Thr Thr Lys Leu Val  Tyr Ala Asn Glu Cys  Ala Asn Phe 
    1190                 1195                 1200             


Thr Thr  Asn Val Ser Ala Arg  Phe Trp Leu Ser Asp  Cys Pro Arg 
    1205                 1210                 1215             


Thr Ala  Glu Ala Val Asn Phe  Ala Thr Leu Leu Tyr  Lys Glu Leu 
    1220                 1225                 1230             


Thr Ala  Val Pro Tyr Met Ala  Lys Phe Val Ile Phe  Ala Lys Met 
    1235                 1240                 1245             


Asn Asp  Pro Arg Glu Gly Arg  Leu Arg Cys Tyr Cys  Met Thr Asp 
    1250                 1255                 1260             


Asp Lys  Val Asp Lys Thr Leu  Glu Gln His Glu Asn  Phe Val Glu 
    1265                 1270                 1275             


Val Ala  Arg Ser Arg Asp Ile  Glu Val Leu Glu Gly  Met Ser Leu 
    1280                 1285                 1290             


Phe Ala  Glu Leu Ser Gly Asn  Leu Val Pro Val Lys  Lys Ala Ala 
    1295                 1300                 1305             


Gln Gln  Arg Ser Phe His Phe  Gln Ser Phe Arg Glu  Asn Arg Leu 
    1310                 1315                 1320             


Ala Met  Pro Val Lys Val Arg  Asp Ser Ser Arg Glu  Pro Gly Gly 
    1325                 1330                 1335             


Ser Leu  Ser Phe Leu Arg Lys  Ala Met Lys Tyr Glu  Asp Thr Gln 
    1340                 1345                 1350             


His Ile  Leu Cys His Leu Asn  Ile Thr Met Pro Pro  Cys Ala Lys 
    1355                 1360                 1365             


Gly Ser  Gly Ala Glu Asp Arg  Arg Arg Thr Pro Thr  Pro Leu Ala 
    1370                 1375                 1380             


Leu Arg  Tyr Ser Ile Leu Ser  Glu Ser Thr Pro Gly  Ser Leu Ser 
    1385                 1390                 1395             


Gly Thr  Glu Gln Ala Glu Met  Lys Met Ala Val Ile  Ser Glu His 
    1400                 1405                 1410             


Leu Gly  Leu Ser Trp Ala Glu  Leu Ala Arg Glu Leu  Gln Phe Ser 
    1415                 1420                 1425             


Val Glu  Asp Ile Asn Arg Ile  Arg Val Glu Asn Pro  Asn Ser Leu 
    1430                 1435                 1440             


Leu Glu  Gln Ser Val Ala Leu  Leu Asn Leu Trp Val  Ile Arg Glu 
    1445                 1450                 1455             


Gly Gln  Asn Ala Asn Met Glu  Asn Leu Tyr Thr Ala  Leu Gln Ser 
    1460                 1465                 1470             


Ile Asp  Arg Gly Glu Ile Val  Asn Met Leu Glu Gly  Ser Gly Arg 
    1475                 1480                 1485             


Gln Ser  Arg Asn Leu Lys Pro  Asp Arg Arg His Thr  Asp Arg Asp 
    1490                 1495                 1500             


Tyr Ser  Leu Ser Pro Ser Gln  Met Asn Gly Tyr Ser  Ser Leu Gln 
    1505                 1510                 1515             


Asp Glu  Leu Leu Ser Pro Ala  Ser Leu Gly Cys Ala  Leu Ser Ser 
    1520                 1525                 1530             


Pro Leu  Arg Ala Asp Gln Tyr  Trp Asn Glu Val Ala  Val Leu Asp 
    1535                 1540                 1545             


Ala Ile  Pro Leu Ala Ala Thr  Glu His Asp Thr Met  Leu Glu Met 
    1550                 1555                 1560             


Ser Asp  Met Gln Val Trp Ser  Ala Gly Leu Thr Pro  Ser Leu Val 
    1565                 1570                 1575             


Thr Ala  Glu Asp Ser Ser Leu  Glu Cys Ser Lys Ala  Glu Asp Ser 
    1580                 1585                 1590             


Asp Ala  Thr Gly His Glu Trp  Lys Leu Glu Gly Ala  Leu Ser Glu 
    1595                 1600                 1605             


Glu Pro  Arg Gly Pro Glu Leu  Gly Ser Leu Glu Leu  Val Glu Asp 
    1610                 1615                 1620             


Asp Thr  Val Asp Ser Asp Ala  Thr Asn Gly Leu Ile  Asp Leu Leu 
    1625                 1630                 1635             


Glu Gln  Glu Glu Gly Gln Arg  Ser Glu Glu Lys Leu  Pro Gly Ser 
    1640                 1645                 1650             


Lys Arg  Gln Asp Asp Ala Thr  Gly Ala Gly Gln Asp  Ser Glu Asn 
    1655                 1660                 1665             


Glu Val  Ser Leu Val Ser Gly  His Gln Arg Gly Gln  Ala Arg Ile 
    1670                 1675                 1680             


Thr His  Ser Pro Thr Val Ser  Gln Val Thr Glu Arg  Ser Gln Asp 
    1685                 1690                 1695             


Arg Leu  Gln Asp Trp Asp Ala  Asp Gly Ser Ile Val  Ser Tyr Leu 
    1700                 1705                 1710             


Gln Asp  Ala Ala Gln Gly Ser  Trp Gln Glu Glu Val  Thr Gln Gly 
    1715                 1720                 1725             


Pro His  Ser Phe Gln Gly Thr  Ser Thr Met Thr Glu  Gly Leu Glu 
    1730                 1735                 1740             


Pro Gly  Gly Ser Gln Glu Tyr  Glu Lys Val Leu Val  Ser Val Ser 
    1745                 1750                 1755             


Glu His  Thr Trp Thr Glu Gln  Pro Glu Ala Glu Ser  Ser Gln Ala 
    1760                 1765                 1770             


Asp Arg  Asp Arg Arg Gln Gln  Gly Gln Glu Glu Gln  Val Gln Glu 
    1775                 1780                 1785             


Ala Lys  Asn Thr Phe Thr Gln  Val Val Gln Gly Asn  Glu Phe Gln 
    1790                 1795                 1800             


Asn Ile  Pro Gly Glu Gln Val  Thr Glu Glu Gln Phe  Thr Asp Glu 
    1805                 1810                 1815             


Gln Gly  Asn Ile Val Thr Lys  Lys Ile Ile Arg Lys  Val Val Arg 
    1820                 1825                 1830             


Gln Ile  Asp Leu Ser Ser Ala  Asp Ala Ala Gln Glu  His Glu Glu 
    1835                 1840                 1845             


Val Glu  Leu Arg Gly Ser Gly  Leu Gln Pro Asp Leu  Ile Glu Gly 
    1850                 1855                 1860             


Arg Lys  Gly Ala Gln Ile Val  Lys Arg Ala Ser Leu  Lys Arg Gly 
    1865                 1870                 1875             


Lys Gln  
    1880 


<210>  835
<211>  1881
<212>  PRT
<213>  Homo Sapiens

<400>  835

Met Pro Tyr Ser Val Gly Phe Arg Glu Ala Asp Ala Ala Thr Ser Phe 
1               5                   10                  15      


Leu Arg Ala Ala Arg Ser Gly Asn Leu Asp Lys Ala Leu Asp His Leu 
            20                  25                  30          


Arg Asn Gly Val Asp Ile Asn Thr Cys Asn Gln Asn Gly Leu Asn Gly 
        35                  40                  45              


Leu His Leu Ala Ser Lys Glu Gly His Val Lys Met Val Val Glu Leu 
    50                  55                  60                  


Leu His Lys Glu Ile Ile Leu Glu Thr Thr Thr Lys Lys Gly Asn Thr 
65                  70                  75                  80  


Ala Leu His Ile Ala Ala Leu Ala Gly Gln Asp Glu Val Val Arg Glu 
                85                  90                  95      


Leu Val Asn Tyr Gly Ala Asn Val Asn Ala Gln Ser Gln Lys Gly Phe 
            100                 105                 110         


Thr Pro Leu Tyr Met Ala Ala Gln Glu Asn His Leu Glu Val Val Lys 
        115                 120                 125             


Phe Leu Leu Glu Asn Gly Ala Asn Gln Asn Val Ala Thr Glu Asp Gly 
    130                 135                 140                 


Phe Thr Pro Leu Ala Val Ala Leu Gln Gln Gly His Glu Asn Val Val 
145                 150                 155                 160 


Ala His Leu Ile Asn Tyr Gly Thr Lys Gly Lys Val Arg Leu Pro Ala 
                165                 170                 175     


Leu His Ile Ala Ala Arg Asn Asp Asp Thr Arg Thr Ala Ala Val Leu 
            180                 185                 190         


Leu Gln Asn Asp Pro Asn Pro Asp Val Leu Ser Lys Thr Gly Phe Thr 
        195                 200                 205             


Pro Leu His Ile Ala Ala His Tyr Glu Asn Leu Asn Val Ala Gln Leu 
    210                 215                 220                 


Leu Leu Asn Arg Gly Ala Ser Val Asn Phe Thr Pro Gln Asn Gly Ile 
225                 230                 235                 240 


Thr Pro Leu His Ile Ala Ser Arg Arg Gly Asn Val Ile Met Val Arg 
                245                 250                 255     


Leu Leu Leu Asp Arg Gly Ala Gln Ile Glu Thr Lys Thr Lys Asp Glu 
            260                 265                 270         


Leu Thr Pro Leu His Cys Ala Ala Arg Asn Gly His Val Arg Ile Ser 
        275                 280                 285             


Glu Ile Leu Leu Asp His Gly Ala Pro Ile Gln Ala Lys Thr Lys Asn 
    290                 295                 300                 


Gly Leu Ser Pro Ile His Met Ala Ala Gln Gly Asp His Leu Asp Cys 
305                 310                 315                 320 


Val Arg Leu Leu Leu Gln Tyr Asp Ala Glu Ile Asp Asp Ile Thr Leu 
                325                 330                 335     


Asp His Leu Thr Pro Leu His Val Ala Ala His Cys Gly His His Arg 
            340                 345                 350         


Val Ala Lys Val Leu Leu Asp Lys Gly Ala Lys Pro Asn Ser Arg Ala 
        355                 360                 365             


Leu Asn Gly Phe Thr Pro Leu His Ile Ala Cys Lys Lys Asn His Val 
    370                 375                 380                 


Arg Val Met Glu Leu Leu Leu Lys Thr Gly Ala Ser Ile Asp Ala Val 
385                 390                 395                 400 


Thr Glu Ser Gly Leu Thr Pro Leu His Val Ala Ser Phe Met Gly His 
                405                 410                 415     


Leu Pro Ile Val Lys Asn Leu Leu Gln Arg Gly Ala Ser Pro Asn Val 
            420                 425                 430         


Ser Asn Val Lys Val Glu Thr Pro Leu His Met Ala Ala Arg Ala Gly 
        435                 440                 445             


His Thr Glu Val Ala Lys Tyr Leu Leu Gln Asn Lys Ala Lys Val Asn 
    450                 455                 460                 


Ala Lys Ala Lys Asp Asp Gln Thr Pro Leu His Cys Ala Ala Arg Ile 
465                 470                 475                 480 


Gly His Thr Asn Met Val Lys Leu Leu Leu Glu Asn Asn Ala Asn Pro 
                485                 490                 495     


Asn Leu Ala Thr Thr Ala Gly His Thr Pro Leu His Ile Ala Ala Arg 
            500                 505                 510         


Glu Gly His Val Glu Thr Val Leu Ala Leu Leu Glu Lys Glu Ala Ser 
        515                 520                 525             


Gln Ala Cys Met Thr Lys Lys Gly Phe Thr Pro Leu His Val Ala Ala 
    530                 535                 540                 


Lys Tyr Gly Lys Val Arg Val Ala Glu Leu Leu Leu Glu Arg Asp Ala 
545                 550                 555                 560 


His Pro Asn Ala Ala Gly Lys Asn Gly Leu Thr Pro Leu His Val Ala 
                565                 570                 575     


Val His His Asn Asn Leu Asp Ile Val Lys Leu Leu Leu Pro Arg Gly 
            580                 585                 590         


Gly Ser Pro His Ser Pro Ala Trp Asn Gly Tyr Thr Pro Leu His Ile 
        595                 600                 605             


Ala Ala Lys Gln Asn Gln Val Glu Val Ala Arg Ser Leu Leu Gln Tyr 
    610                 615                 620                 


Gly Gly Ser Ala Asn Ala Glu Ser Val Gln Gly Val Thr Pro Leu His 
625                 630                 635                 640 


Leu Ala Ala Gln Glu Gly His Ala Glu Met Val Ala Leu Leu Leu Ser 
                645                 650                 655     


Lys Gln Ala Asn Gly Asn Leu Gly Asn Lys Ser Gly Leu Thr Pro Leu 
            660                 665                 670         


His Leu Val Ala Gln Glu Gly His Val Pro Val Ala Asp Val Leu Ile 
        675                 680                 685             


Lys His Gly Val Met Val Asp Ala Thr Thr Arg Met Gly Tyr Thr Pro 
    690                 695                 700                 


Leu His Val Ala Ser His Tyr Gly Asn Ile Lys Leu Val Lys Phe Leu 
705                 710                 715                 720 


Leu Gln His Gln Ala Asp Val Asn Ala Lys Thr Lys Leu Gly Tyr Ser 
                725                 730                 735     


Pro Leu His Gln Ala Ala Gln Gln Gly His Thr Asp Ile Val Thr Leu 
            740                 745                 750         


Leu Leu Lys Asn Gly Ala Ser Pro Asn Glu Val Ser Ser Asp Gly Thr 
        755                 760                 765             


Thr Pro Leu Ala Ile Ala Lys Arg Leu Gly Tyr Ile Ser Val Thr Asp 
    770                 775                 780                 


Val Leu Lys Val Val Thr Asp Glu Thr Ser Phe Val Leu Val Ser Asp 
785                 790                 795                 800 


Lys His Arg Met Ser Phe Pro Glu Thr Val Asp Glu Ile Leu Asp Val 
                805                 810                 815     


Ser Glu Asp Glu Gly Glu Glu Leu Ile Ser Phe Lys Ala Glu Arg Arg 
            820                 825                 830         


Asp Ser Arg Asp Val Asp Glu Glu Lys Glu Leu Leu Asp Phe Val Pro 
        835                 840                 845             


Lys Leu Asp Gln Val Val Glu Ser Pro Ala Ile Pro Arg Ile Pro Cys 
    850                 855                 860                 


Ala Met Pro Glu Thr Val Val Ile Arg Ser Glu Glu Gln Glu Gln Ala 
865                 870                 875                 880 


Ser Lys Glu Tyr Asp Glu Asp Ser Leu Ile Pro Ser Ser Pro Ala Thr 
                885                 890                 895     


Glu Thr Ser Asp Asn Ile Ser Pro Val Ala Ser Pro Val His Thr Gly 
            900                 905                 910         


Phe Leu Val Ser Phe Met Val Asp Ala Arg Gly Gly Ser Met Arg Gly 
        915                 920                 925             


Ser Arg His Asn Gly Leu Arg Val Val Ile Pro Pro Arg Thr Cys Ala 
    930                 935                 940                 


Ala Pro Thr Arg Ile Thr Cys Arg Leu Val Lys Pro Gln Lys Leu Ser 
945                 950                 955                 960 


Thr Pro Pro Pro Leu Ala Glu Glu Glu Gly Leu Ala Ser Arg Ile Ile 
                965                 970                 975     


Ala Leu Gly Pro Thr Gly Ala Gln Phe Leu Ser Pro Val Ile Val Glu 
            980                 985                 990         


Ile Pro His Phe Ala Ser His Gly  Arg Gly Asp Arg Glu  Leu Val Val 
        995                 1000                 1005             


Leu Arg  Ser Glu Asn Gly Ser  Val Trp Lys Glu His  Arg Ser Arg 
    1010                 1015                 1020             


Tyr Gly  Glu Ser Tyr Leu Asp  Gln Ile Leu Asn Gly  Met Asp Glu 
    1025                 1030                 1035             


Glu Leu  Gly Ser Leu Glu Glu  Leu Glu Lys Lys Arg  Val Cys Arg 
    1040                 1045                 1050             


Ile Ile  Thr Thr Asp Phe Pro  Leu Tyr Phe Val Ile  Met Ser Arg 
    1055                 1060                 1065             


Leu Cys  Gln Asp Tyr Asp Thr  Ile Gly Pro Glu Gly  Gly Ser Leu 
    1070                 1075                 1080             


Lys Ser  Lys Leu Val Pro Leu  Val Gln Ala Thr Phe  Pro Glu Asn 
    1085                 1090                 1095             


Ala Val  Thr Lys Arg Val Lys  Leu Ala Leu Gln Ala  Gln Pro Val 
    1100                 1105                 1110             


Pro Asp  Glu Leu Val Thr Lys  Leu Leu Gly Asn Gln  Ala Thr Phe 
    1115                 1120                 1125             


Ser Pro  Ile Val Thr Val Glu  Pro Arg Arg Arg Lys  Phe His Arg 
    1130                 1135                 1140             


Pro Ile  Gly Leu Arg Ile Pro  Leu Pro Pro Ser Trp  Thr Asp Asn 
    1145                 1150                 1155             


Pro Arg  Asp Ser Gly Glu Gly  Asp Thr Thr Ser Leu  Arg Leu Leu 
    1160                 1165                 1170             


Cys Ser  Val Ile Gly Gly Thr  Asp Gln Ala Gln Trp  Glu Asp Ile 
    1175                 1180                 1185             


Thr Gly  Thr Thr Lys Leu Val  Tyr Ala Asn Glu Cys  Ala Asn Phe 
    1190                 1195                 1200             


Thr Thr  Asn Val Ser Ala Arg  Phe Trp Leu Ser Asp  Cys Pro Arg 
    1205                 1210                 1215             


Thr Ala  Glu Ala Val Asn Phe  Ala Thr Leu Leu Tyr  Lys Glu Leu 
    1220                 1225                 1230             


Thr Ala  Val Pro Tyr Met Ala  Lys Phe Val Ile Phe  Ala Lys Met 
    1235                 1240                 1245             


Asn Asp  Pro Arg Glu Gly Arg  Leu Arg Cys Tyr Cys  Met Thr Asp 
    1250                 1255                 1260             


Asp Lys  Val Asp Lys Thr Leu  Glu Gln His Glu Asn  Phe Val Glu 
    1265                 1270                 1275             


Val Ala  Arg Ser Arg Asp Ile  Glu Val Leu Glu Gly  Met Ser Leu 
    1280                 1285                 1290             


Phe Ala  Glu Leu Ser Gly Asn  Leu Val Pro Val Lys  Lys Ala Ala 
    1295                 1300                 1305             


Gln Gln  Arg Ser Phe His Phe  Gln Ser Phe Arg Glu  Asn Arg Leu 
    1310                 1315                 1320             


Ala Met  Pro Val Lys Val Arg  Asp Ser Ser Arg Glu  Pro Gly Gly 
    1325                 1330                 1335             


Ser Leu  Ser Phe Leu Arg Lys  Ala Met Lys Tyr Glu  Asp Thr Gln 
    1340                 1345                 1350             


His Ile  Leu Cys His Leu Asn  Ile Thr Met Pro Pro  Cys Ala Lys 
    1355                 1360                 1365             


Gly Ser  Gly Ala Glu Asp Arg  Arg Arg Thr Pro Thr  Pro Leu Ala 
    1370                 1375                 1380             


Leu Arg  Tyr Ser Ile Leu Ser  Glu Ser Thr Pro Gly  Ser Leu Ser 
    1385                 1390                 1395             


Gly Thr  Glu Gln Ala Glu Met  Lys Met Ala Val Ile  Ser Glu His 
    1400                 1405                 1410             


Leu Gly  Leu Ser Trp Ala Glu  Leu Ala Arg Glu Leu  Gln Phe Ser 
    1415                 1420                 1425             


Val Glu  Asp Ile Asn Arg Ile  Arg Val Glu Asn Pro  Asn Ser Leu 
    1430                 1435                 1440             


Leu Glu  Gln Ser Val Ala Leu  Leu Asn Leu Trp Val  Ile Arg Glu 
    1445                 1450                 1455             


Gly Gln  Asn Ala Asn Met Glu  Asn Leu Tyr Thr Ala  Leu Gln Ser 
    1460                 1465                 1470             


Ile Asp  Arg Gly Glu Ile Val  Asn Met Leu Glu Gly  Ser Gly Arg 
    1475                 1480                 1485             


Gln Ser  Arg Asn Leu Lys Pro  Asp Arg Arg His Thr  Asp Arg Asp 
    1490                 1495                 1500             


Tyr Ser  Leu Ser Pro Ser Gln  Met Asn Gly Tyr Ser  Ser Leu Gln 
    1505                 1510                 1515             


Asp Glu  Leu Leu Ser Pro Ala  Ser Leu Gly Cys Ala  Leu Ser Ser 
    1520                 1525                 1530             


Pro Leu  Arg Ala Asp Gln Tyr  Trp Asn Glu Val Ala  Val Leu Asp 
    1535                 1540                 1545             


Ala Ile  Pro Leu Ala Ala Thr  Glu His Asp Thr Met  Leu Glu Met 
    1550                 1555                 1560             


Ser Asp  Met Gln Val Trp Ser  Ala Gly Leu Thr Pro  Ser Leu Val 
    1565                 1570                 1575             


Thr Ala  Glu Asp Ser Ser Leu  Glu Cys Ser Lys Ala  Glu Asp Ser 
    1580                 1585                 1590             


Asp Ala  Thr Gly His Glu Trp  Lys Leu Glu Gly Ala  Leu Ser Glu 
    1595                 1600                 1605             


Glu Pro  Arg Gly Pro Glu Leu  Gly Ser Leu Glu Leu  Val Glu Asp 
    1610                 1615                 1620             


Asp Thr  Val Asp Ser Asp Ala  Thr Asn Gly Leu Ile  Asp Leu Leu 
    1625                 1630                 1635             


Glu Gln  Glu Glu Gly Gln Arg  Ser Glu Glu Lys Leu  Pro Gly Ser 
    1640                 1645                 1650             


Lys Arg  Gln Asp Asp Ala Thr  Gly Ala Gly Gln Asp  Ser Glu Asn 
    1655                 1660                 1665             


Glu Val  Ser Leu Val Ser Gly  His Gln Arg Gly Gln  Ala Arg Ile 
    1670                 1675                 1680             


Thr His  Ser Pro Thr Val Ser  Gln Val Thr Glu Arg  Ser Gln Asp 
    1685                 1690                 1695             


Arg Leu  Gln Asp Trp Asp Ala  Asp Gly Ser Ile Val  Ser Tyr Leu 
    1700                 1705                 1710             


Gln Asp  Ala Ala Gln Gly Ser  Trp Gln Glu Glu Val  Thr Gln Gly 
    1715                 1720                 1725             


Pro His  Ser Phe Gln Gly Thr  Ser Thr Met Thr Glu  Gly Leu Glu 
    1730                 1735                 1740             


Pro Gly  Gly Ser Gln Glu Tyr  Glu Lys Val Leu Val  Ser Val Ser 
    1745                 1750                 1755             


Glu His  Thr Trp Thr Glu Gln  Pro Glu Ala Glu Ser  Ser Gln Ala 
    1760                 1765                 1770             


Asp Arg  Asp Arg Arg Gln Gln  Gly Gln Glu Glu Gln  Val Gln Glu 
    1775                 1780                 1785             


Ala Lys  Asn Thr Phe Thr Gln  Val Val Gln Gly Asn  Glu Phe Gln 
    1790                 1795                 1800             


Asn Ile  Pro Gly Glu Gln Val  Thr Glu Glu Gln Phe  Thr Asp Glu 
    1805                 1810                 1815             


Gln Gly  Asn Ile Val Thr Lys  Lys Ile Ile Arg Lys  Val Val Arg 
    1820                 1825                 1830             


Gln Ile  Asp Leu Ser Ser Ala  Asp Ala Ala Gln Glu  His Glu Glu 
    1835                 1840                 1845             


Val Thr  Val Glu Gly Pro Leu  Glu Asp Pro Ser Glu  Leu Glu Val 
    1850                 1855                 1860             


Asp Ile  Asp Tyr Phe Met Lys  His Ser Lys Asp His  Thr Ser Thr 
    1865                 1870                 1875             


Pro Asn  Pro 
    1880     


<210>  836
<211>  109
<212>  PRT
<213>  Homo Sapiens

<400>  836

Met Trp Thr Phe Val Thr Gln Leu Leu Val Thr Leu Val Leu Leu Ser 
1               5                   10                  15      


Phe Phe Leu Val Ser Cys Gln Asn Val Met His Ile Val Arg Gly Ser 
            20                  25                  30          


Leu Cys Phe Val Leu Lys His Ile His Gln Glu Leu Asp Lys Glu Leu 
        35                  40                  45              


Gly Glu Ser Glu Gly Leu Ser Asp Asp Glu Glu Thr Ile Ser Thr Arg 
    50                  55                  60                  


Val Val Arg Arg Arg Val Phe Leu Lys Gly Asn Glu Phe Gln Asn Ile 
65                  70                  75                  80  


Pro Gly Glu Gln Val Thr Glu Glu Gln Phe Thr Asp Glu Gln Gly Asn 
                85                  90                  95      


Ile Val Thr Lys Lys Asp His Thr Ser Thr Pro Asn Pro 
            100                 105                 


<210>  837
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  837

Met Trp Thr Phe Val Thr Gln Leu Leu Val Thr Leu Val Leu Leu Ser 
1               5                   10                  15      


Phe Phe Leu Val Ser Cys Gln Asn Val Met His Ile Val Arg Gly Ser 
            20                  25                  30          


Leu Cys Phe Val Leu Lys His Ile His Gln Glu Leu Asp Lys Glu Leu 
        35                  40                  45              


Gly Glu Ser Glu Gly Leu Ser Asp Asp Glu Glu Thr Ile Ser Thr Arg 
    50                  55                  60                  


Val Val Arg Arg Arg Val Phe Leu Lys Gly Asn Glu Phe Gln Asn Ile 
65                  70                  75                  80  


Pro Gly Glu Gln Val Thr Glu Glu Gln Phe Thr Asp Glu Gln Gly Asn 
                85                  90                  95      


Ile Val Thr Lys Lys Ile Ile Arg Lys Val Val Arg Gln Ile Asp Leu 
            100                 105                 110         


Ser Ser Ala Asp Ala Ala Gln Glu His Glu Glu Asp His Thr Ser Thr 
        115                 120                 125             


Pro Asn Pro 
    130     


<210>  838
<211>  155
<212>  PRT
<213>  Homo Sapiens

<400>  838

Met Trp Thr Phe Val Thr Gln Leu Leu Val Thr Leu Val Leu Leu Ser 
1               5                   10                  15      


Phe Phe Leu Val Ser Cys Gln Asn Val Met His Ile Val Arg Gly Ser 
            20                  25                  30          


Leu Cys Phe Val Leu Lys His Ile His Gln Glu Leu Asp Lys Glu Leu 
        35                  40                  45              


Gly Glu Ser Glu Gly Leu Ser Asp Asp Glu Glu Thr Ile Ser Thr Arg 
    50                  55                  60                  


Val Val Arg Arg Arg Val Phe Leu Lys Gly Asn Glu Phe Gln Asn Ile 
65                  70                  75                  80  


Pro Gly Glu Gln Val Thr Glu Glu Gln Phe Thr Asp Glu Gln Gly Asn 
                85                  90                  95      


Ile Val Thr Lys Lys Ile Ile Arg Lys Val Val Arg Gln Ile Asp Leu 
            100                 105                 110         


Ser Ser Ala Asp Ala Ala Gln Glu His Glu Glu Val Glu Leu Arg Gly 
        115                 120                 125             


Ser Gly Leu Gln Pro Asp Leu Ile Glu Gly Arg Lys Gly Ala Gln Ile 
    130                 135                 140                 


Val Lys Arg Ala Ser Leu Lys Arg Gly Lys Gln 
145                 150                 155 


<210>  839
<211>  156
<212>  PRT
<213>  Homo Sapiens

<400>  839

Met Trp Thr Phe Val Thr Gln Leu Leu Val Thr Leu Val Leu Leu Ser 
1               5                   10                  15      


Phe Phe Leu Val Ser Cys Gln Asn Val Met His Ile Val Arg Gly Ser 
            20                  25                  30          


Leu Cys Phe Val Leu Lys His Ile His Gln Glu Leu Asp Lys Glu Leu 
        35                  40                  45              


Gly Glu Ser Glu Gly Leu Ser Asp Asp Glu Glu Thr Ile Ser Thr Arg 
    50                  55                  60                  


Val Val Arg Arg Arg Val Phe Leu Lys Gly Asn Glu Phe Gln Asn Ile 
65                  70                  75                  80  


Pro Gly Glu Gln Val Thr Glu Glu Gln Phe Thr Asp Glu Gln Gly Asn 
                85                  90                  95      


Ile Val Thr Lys Lys Ile Ile Arg Lys Val Val Arg Gln Ile Asp Leu 
            100                 105                 110         


Ser Ser Ala Asp Ala Ala Gln Glu His Glu Glu Val Thr Val Glu Gly 
        115                 120                 125             


Pro Leu Glu Asp Pro Ser Glu Leu Glu Val Asp Ile Asp Tyr Phe Met 
    130                 135                 140                 


Lys His Ser Lys Asp His Thr Ser Thr Pro Asn Pro 
145                 150                 155     


<210>  840
<211>  113
<212>  PRT
<213>  Homo Sapiens

<400>  840

Met Trp Thr Phe Val Thr Gln Leu Leu Val Thr Leu Val Leu Leu Ser 
1               5                   10                  15      


Phe Phe Leu Val Ser Cys Gln Asn Val Met His Ile Val Arg Gly Ser 
            20                  25                  30          


Leu Cys Phe Val Leu Lys His Ile His Gln Glu Leu Asp Lys Glu Leu 
        35                  40                  45              


Gly Glu Ser Glu Gly Leu Ser Asp Asp Glu Glu Thr Ile Ser Thr Arg 
    50                  55                  60                  


Val Val Arg Arg Arg Val Phe Leu Lys Gly Asn Glu Phe Gln Asn Ile 
65                  70                  75                  80  


Pro Gly Glu Gln Val Thr Glu Glu Gln Phe Thr Asp Glu Gln Gly Asn 
                85                  90                  95      


Ile Val Thr Lys Lys Val Glu Leu Arg Gly Ser Gly Leu Gln Pro Asp 
            100                 105                 110         


Leu 
    


<210>  841
<211>  177
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  841

Xaa Glu Asp Thr Gln His Ile Leu Cys His Leu Asn Ile Thr Met Pro 
1               5                   10                  15      


Pro Cys Ala Lys Gly Ser Gly Ala Glu Asp Arg Arg Arg Thr Pro Thr 
            20                  25                  30          


Pro Leu Ala Leu Arg Tyr Ser Ile Leu Ser Glu Ser Thr Pro Gly Ser 
        35                  40                  45              


Leu Ser Gly Thr Glu Gln Ala Glu Met Lys Met Ala Val Ile Ser Glu 
    50                  55                  60                  


His Leu Gly Leu Ser Trp Ala Glu Leu Ala Arg Glu Leu Gln Phe Ser 
65                  70                  75                  80  


Val Glu Asp Ile Asn Arg Ile Arg Val Glu Asn Pro Asn Ser Leu Leu 
                85                  90                  95      


Glu Gln Ser Val Ala Leu Leu Asn Leu Trp Val Ile Arg Glu Gly Gln 
            100                 105                 110         


Asn Ala Asn Met Glu Asn Leu Tyr Thr Ala Leu Gln Ser Ile Asp Arg 
        115                 120                 125             


Gly Glu Ile Val Asn Met Leu Glu Gly Ser Gly Arg Gln Ser Arg Asn 
    130                 135                 140                 


Leu Lys Pro Asp Arg Arg His Thr Asp Arg Asp Tyr Ser Leu Ser Pro 
145                 150                 155                 160 


Ser Gln Met Asn Gly Gly Arg Ser Glu Val Arg Arg Glu Ala Ala Arg 
                165                 170                 175     


Phe 
    


<210>  842
<211>  1040
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  842

Xaa Ile Lys His Gly Val Met Val Asp Ala Thr Thr Arg Met Gly Tyr 
1               5                   10                  15      


Thr Pro Leu His Val Ala Ser His Tyr Gly Asn Ile Lys Leu Val Lys 
            20                  25                  30          


Phe Leu Leu Gln His Gln Ala Asp Val Asn Ala Lys Thr Lys Leu Gly 
        35                  40                  45              


Tyr Ser Pro Leu His Gln Ala Ala Gln Gln Gly His Thr Asp Ile Val 
    50                  55                  60                  


Thr Leu Leu Leu Lys Asn Gly Ala Ser Pro Asn Glu Val Ser Ser Asp 
65                  70                  75                  80  


Gly Thr Thr Pro Leu Ala Ile Ala Lys Arg Leu Gly Tyr Ile Ser Val 
                85                  90                  95      


Thr Asp Val Leu Lys Val Val Thr Asp Glu Thr Ser Phe Val Leu Val 
            100                 105                 110         


Ser Asp Lys His Arg Met Ser Phe Pro Glu Thr Val Asp Glu Ile Leu 
        115                 120                 125             


Asp Val Ser Glu Asp Glu Gly Thr Ala His Ile Thr Ile Met Gly Glu 
    130                 135                 140                 


Glu Leu Ile Ser Phe Lys Ala Glu Arg Arg Asp Ser Arg Asp Val Asp 
145                 150                 155                 160 


Glu Glu Lys Glu Leu Leu Asp Phe Val Pro Lys Leu Asp Gln Val Val 
                165                 170                 175     


Glu Ser Pro Ala Ile Pro Arg Ile Pro Cys Ala Met Pro Glu Thr Val 
            180                 185                 190         


Val Ile Arg Ser Glu Glu Gln Glu Gln Ala Ser Lys Glu Tyr Asp Glu 
        195                 200                 205             


Asp Ser Leu Ile Pro Ser Ser Pro Ala Thr Glu Thr Ser Asp Asn Ile 
    210                 215                 220                 


Ser Pro Val Ala Ser Pro Val His Thr Gly Phe Leu Val Ser Phe Met 
225                 230                 235                 240 


Val Asp Ala Arg Gly Gly Ser Met Arg Gly Ser Arg His Asn Gly Leu 
                245                 250                 255     


Arg Val Val Ile Pro Pro Arg Thr Cys Ala Ala Pro Thr Arg Ile Thr 
            260                 265                 270         


Cys Arg Leu Val Lys Pro Gln Lys Leu Ser Thr Pro Pro Pro Leu Ala 
        275                 280                 285             


Glu Glu Glu Gly Leu Ala Ser Arg Ile Ile Ala Leu Gly Pro Thr Gly 
    290                 295                 300                 


Ala Gln Phe Leu Ser Pro Val Ile Val Glu Ile Pro His Phe Ala Ser 
305                 310                 315                 320 


His Gly Arg Gly Asp Arg Glu Leu Val Val Leu Arg Ser Glu Asn Gly 
                325                 330                 335     


Ser Val Trp Lys Glu His Arg Ser Arg Tyr Gly Glu Ser Tyr Leu Asp 
            340                 345                 350         


Gln Ile Leu Asn Gly Met Asp Glu Glu Leu Gly Ser Leu Glu Glu Leu 
        355                 360                 365             


Glu Lys Lys Arg Val Cys Arg Ile Ile Thr Thr Asp Phe Pro Leu Tyr 
    370                 375                 380                 


Phe Val Ile Met Ser Arg Leu Cys Gln Asp Tyr Asp Thr Ile Gly Pro 
385                 390                 395                 400 


Glu Gly Gly Ser Leu Lys Ser Lys Leu Val Pro Leu Val Gln Ala Thr 
                405                 410                 415     


Phe Pro Glu Asn Ala Val Thr Lys Arg Val Lys Leu Ala Leu Gln Ala 
            420                 425                 430         


Gln Pro Val Pro Asp Glu Leu Val Thr Lys Leu Leu Gly Asn Gln Ala 
        435                 440                 445             


Thr Phe Ser Pro Ile Val Thr Val Glu Pro Arg Arg Arg Lys Phe His 
    450                 455                 460                 


Arg Pro Ile Gly Leu Arg Ile Pro Leu Pro Pro Ser Trp Thr Asp Asn 
465                 470                 475                 480 


Pro Arg Asp Ser Gly Glu Gly Asp Thr Thr Ser Leu Arg Leu Leu Cys 
                485                 490                 495     


Ser Val Ile Gly Gly Thr Asp Gln Ala Gln Trp Glu Asp Ile Thr Gly 
            500                 505                 510         


Thr Thr Lys Leu Val Tyr Ala Asn Glu Cys Ala Asn Phe Thr Thr Asn 
        515                 520                 525             


Val Ser Ala Arg Phe Trp Leu Ser Asp Cys Pro Arg Thr Ala Glu Ala 
    530                 535                 540                 


Val Asn Phe Ala Thr Leu Leu Tyr Lys Glu Leu Thr Ala Val Pro Tyr 
545                 550                 555                 560 


Met Ala Lys Phe Val Ile Phe Ala Lys Met Asn Asp Pro Arg Glu Gly 
                565                 570                 575     


Arg Leu Arg Cys Tyr Cys Met Thr Asp Asp Lys Val Asp Lys Thr Leu 
            580                 585                 590         


Glu Gln His Glu Asn Phe Val Glu Val Ala Arg Ser Arg Asp Ile Glu 
        595                 600                 605             


Val Leu Glu Gly Met Ser Leu Phe Ala Glu Leu Ser Gly Asn Leu Val 
    610                 615                 620                 


Pro Val Lys Lys Ala Ala Gln Gln Arg Ser Phe His Phe Gln Ser Phe 
625                 630                 635                 640 


Arg Glu Asn Arg Leu Ala Met Pro Val Lys Val Arg Asp Ser Ser Arg 
                645                 650                 655     


Glu Pro Gly Gly Ser Leu Ser Phe Leu Arg Lys Ala Met Lys Tyr Glu 
            660                 665                 670         


Asp Thr Gln His Ile Leu Cys His Leu Asn Ile Thr Met Pro Pro Cys 
        675                 680                 685             


Ala Lys Gly Ser Gly Ala Glu Asp Arg Arg Arg Thr Pro Thr Pro Leu 
    690                 695                 700                 


Ala Leu Arg Tyr Ser Ile Leu Ser Glu Ser Thr Pro Gly Ser Leu Ser 
705                 710                 715                 720 


Gly Thr Glu Gln Ala Glu Met Lys Met Ala Val Ile Ser Glu His Leu 
                725                 730                 735     


Gly Leu Ser Trp Ala Glu Leu Ala Arg Glu Leu Gln Phe Ser Val Glu 
            740                 745                 750         


Asp Ile Asn Arg Ile Arg Val Glu Asn Pro Asn Ser Leu Leu Glu Gln 
        755                 760                 765             


Ser Val Ala Leu Leu Asn Leu Trp Val Ile Arg Glu Gly Gln Asn Ala 
    770                 775                 780                 


Asn Met Glu Asn Leu Tyr Thr Ala Leu Gln Ser Ile Asp Arg Gly Glu 
785                 790                 795                 800 


Ile Val Asn Met Leu Glu Gly Ser Gly Arg Gln Ser Arg Asn Leu Lys 
                805                 810                 815     


Pro Asp Arg Arg His Thr Asp Arg Asp Tyr Ser Leu Ser Pro Ser Gln 
            820                 825                 830         


Met Asn Gly His Gln Arg Gly Gln Ala Arg Ile Thr His Ser Pro Thr 
        835                 840                 845             


Val Ser Gln Val Thr Glu Arg Ser Gln Asp Arg Leu Gln Asp Trp Asp 
    850                 855                 860                 


Ala Asp Gly Ser Ile Val Ser Tyr Leu Gln Asp Ala Ala Gln Gly Ser 
865                 870                 875                 880 


Trp Gln Glu Glu Val Thr Gln Gly Pro His Ser Phe Gln Gly Thr Ser 
                885                 890                 895     


Thr Met Thr Glu Gly Leu Glu Pro Gly Gly Ser Gln Glu Tyr Glu Lys 
            900                 905                 910         


Val Leu Val Ser Val Ser Glu His Thr Trp Thr Glu Gln Pro Glu Ala 
        915                 920                 925             


Glu Ser Ser Gln Ala Asp Arg Asp Arg Arg Gln Gln Gly Gln Glu Glu 
    930                 935                 940                 


Gln Val Gln Glu Ala Lys Asn Thr Phe Thr Gln Val Val Gln Gly Asn 
945                 950                 955                 960 


Glu Phe Gln Asn Ile Pro Gly Glu Gln Val Thr Glu Glu Gln Phe Thr 
                965                 970                 975     


Asp Glu Gln Gly Asn Ile Val Thr Lys Lys Ile Ile Arg Lys Val Val 
            980                 985                 990         


Arg Gln Ile Asp Leu Ser Ser Ala  Asp Ala Ala Gln Glu  His Glu Glu 
        995                 1000                 1005             


Val Glu  Leu Arg Gly Ser Gly  Leu Gln Pro Asp Leu  Ile Glu Gly 
    1010                 1015                 1020             


Arg Lys  Gly Ala Gln Ile Val  Lys Arg Ala Ser Leu  Lys Arg Gly 
    1025                 1030                 1035             


Lys Gln  
    1040 


<210>  843
<211>  553
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  843

Xaa Thr Ser Leu Arg Leu Leu Cys Ser Val Ile Gly Gly Thr Asp Gln 
1               5                   10                  15      


Ala Gln Trp Glu Asp Ile Thr Gly Thr Thr Lys Leu Val Tyr Ala Asn 
            20                  25                  30          


Glu Cys Ala Asn Phe Thr Thr Asn Val Ser Ala Arg Phe Trp Leu Ser 
        35                  40                  45              


Asp Cys Pro Arg Thr Ala Glu Ala Val Asn Phe Ala Thr Leu Leu Tyr 
    50                  55                  60                  


Lys Glu Leu Thr Ala Val Pro Tyr Met Ala Lys Phe Val Ile Phe Ala 
65                  70                  75                  80  


Lys Met Asn Asp Pro Arg Glu Gly Arg Leu Arg Cys Tyr Cys Met Thr 
                85                  90                  95      


Asp Asp Lys Val Asp Lys Thr Leu Glu Gln His Glu Asn Phe Val Glu 
            100                 105                 110         


Val Ala Arg Ser Arg Asp Ile Glu Val Leu Glu Gly Met Ser Leu Phe 
        115                 120                 125             


Ala Glu Leu Ser Gly Asn Leu Val Pro Val Lys Lys Ala Ala Gln Gln 
    130                 135                 140                 


Arg Ser Phe His Phe Gln Ser Phe Arg Glu Asn Arg Leu Ala Met Pro 
145                 150                 155                 160 


Val Lys Val Arg Asp Ser Ser Arg Glu Pro Gly Gly Ser Leu Ser Phe 
                165                 170                 175     


Leu Arg Lys Ala Met Lys Tyr Glu Asp Thr Gln His Ile Leu Cys His 
            180                 185                 190         


Leu Asn Ile Thr Met Pro Pro Cys Ala Lys Gly Ser Gly Ala Glu Asp 
        195                 200                 205             


Arg Arg Arg Thr Pro Thr Pro Leu Ala Leu Arg Tyr Ser Ile Leu Ser 
    210                 215                 220                 


Glu Ser Thr Pro Gly Ser Leu Ser Gly Thr Glu Gln Ala Glu Met Lys 
225                 230                 235                 240 


Met Ala Val Ile Ser Glu His Leu Gly Leu Ser Trp Ala Glu Leu Ala 
                245                 250                 255     


Arg Glu Leu Gln Phe Ser Val Glu Asp Ile Asn Arg Ile Arg Val Glu 
            260                 265                 270         


Asn Pro Asn Ser Leu Leu Glu Gln Ser Val Ala Leu Leu Asn Leu Trp 
        275                 280                 285             


Val Ile Arg Glu Gly Gln Asn Ala Asn Met Glu Asn Leu Tyr Thr Ala 
    290                 295                 300                 


Leu Gln Ser Ile Asp Arg Gly Glu Ile Val Asn Met Leu Glu Gly Ser 
305                 310                 315                 320 


Gly Arg Gln Ser Arg Asn Leu Lys Pro Asp Arg Arg His Thr Asp Arg 
                325                 330                 335     


Asp Tyr Ser Leu Ser Pro Ser Gln Met Asn Gly His Gln Arg Gly Gln 
            340                 345                 350         


Ala Arg Ile Thr His Ser Pro Thr Val Ser Gln Val Thr Glu Arg Ser 
        355                 360                 365             


Gln Asp Arg Leu Gln Asp Trp Asp Ala Asp Gly Ser Ile Val Ser Tyr 
    370                 375                 380                 


Leu Gln Asp Ala Ala Gln Gly Ser Trp Gln Glu Glu Val Thr Gln Gly 
385                 390                 395                 400 


Pro His Ser Phe Gln Gly Thr Ser Thr Met Thr Glu Gly Leu Glu Pro 
                405                 410                 415     


Gly Gly Ser Gln Glu Tyr Glu Lys Val Leu Val Ser Val Ser Glu His 
            420                 425                 430         


Thr Trp Thr Glu Gln Pro Glu Ala Glu Ser Ser Gln Ala Asp Arg Asp 
        435                 440                 445             


Arg Arg Gln Gln Gly Gln Glu Glu Gln Val Gln Glu Ala Lys Asn Thr 
    450                 455                 460                 


Phe Thr Gln Val Val Gln Gly Asn Glu Phe Gln Asn Ile Pro Gly Glu 
465                 470                 475                 480 


Gln Val Thr Glu Glu Gln Phe Thr Asp Glu Gln Gly Asn Ile Val Thr 
                485                 490                 495     


Lys Lys Ile Ile Arg Lys Val Val Arg Gln Ile Asp Leu Ser Ser Ala 
            500                 505                 510         


Asp Ala Ala Gln Glu His Glu Glu Val Thr Val Glu Gly Pro Leu Glu 
        515                 520                 525             


Asp Pro Ser Glu Leu Glu Val Asp Ile Asp Tyr Phe Met Lys His Ser 
    530                 535                 540                 


Lys Asp His Thr Ser Thr Pro Asn Pro 
545                 550             


<210>  844
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  844

Ile Gly Arg Arg Val Asn Thr Arg Ala Arg Asn His Val Gly Arg Val 
1               5                   10                  15      


Ala Leu His Trp Ala Ala Gly Ala Gly His Glu Gln Ala Val Arg Leu 
            20                  25                  30          


Leu Leu Glu His Glu Ala Ala Val Asp Glu Glu Asp Ala Val Gly Ala 
        35                  40                  45              


Leu Thr Glu Glu Gly Asn Thr Ala Leu His Leu Ala Ala Gly Arg Gly 
    50                  55                  60                  


His Met Ala Val Leu Gln Arg Leu Val Asp Ile Gly Leu Asp Leu Glu 
65                  70                  75                  80  


Glu Gln Asn Ala Glu Gly Leu Thr Ala Leu His Ser Ala Ala Gly Gly 
                85                  90                  95      


Ser His Pro Asp Cys Val Gln Leu Leu Leu Arg Ala Gly Ser Thr Val 
            100                 105                 110         


Asn Ala Leu Thr Gln Val Ala Arg Pro Ser Gln Asp Cys Gly Arg Leu 
        115                 120                 125             


Leu Ala Ala Glu Pro 
    130             


<210>  845
<211>  423
<212>  PRT
<213>  Homo Sapiens

<400>  845

Met Asn Ala Leu Leu Leu Ser Ala Trp Phe Gly His Leu Arg Ile Leu 
1               5                   10                  15      


Gln Ile Leu Val Asn Ser Gly Ala Lys Ile His Cys Glu Ser Lys Asp 
            20                  25                  30          


Gly Leu Thr Leu Leu His Cys Ala Ala Gln Lys Gly His Val Pro Val 
        35                  40                  45              


Leu Ala Phe Ile Met Glu Asp Leu Glu Asp Val Ala Leu Asp His Val 
    50                  55                  60                  


Asp Lys Leu Gly Arg Thr Ala Phe His Arg Ala Ala Glu His Gly Gln 
65                  70                  75                  80  


Leu Asp Ala Leu Asp Phe Leu Val Gly Ser Gly Cys Asp His Asn Val 
                85                  90                  95      


Lys Asp Lys Glu Gly Asn Thr Ala Leu His Leu Ala Ala Gly Arg Gly 
            100                 105                 110         


His Met Ala Val Leu Gln Arg Leu Val Asp Ile Gly Leu Asp Leu Glu 
        115                 120                 125             


Glu Gln Asn Ala Glu Gly Leu Thr Ala Leu His Ser Ala Ala Gly Gly 
    130                 135                 140                 


Ser His Pro Asp Cys Val Gln Leu Leu Leu Arg Ala Gly Ser Thr Val 
145                 150                 155                 160 


Asn Ala Leu Thr Gln Lys Asn Leu Ser Cys Leu His Tyr Ala Ala Leu 
                165                 170                 175     


Ser Gly Ser Glu Asp Val Ser Arg Val Leu Ile His Ala Gly Gly Cys 
            180                 185                 190         


Ala Asn Val Val Asp His Gln Gly Ala Ser Pro Leu His Leu Ala Val 
        195                 200                 205             


Arg His Asn Phe Pro Ala Leu Val Arg Leu Leu Ile Asn Ser Asp Ser 
    210                 215                 220                 


Asp Val Asn Ala Val Asp Asn Arg Gln Gln Thr Pro Leu His Leu Ala 
225                 230                 235                 240 


Ala Glu His Ala Trp Gln Asp Ile Ala Asp Met Leu Leu Ile Ala Gly 
                245                 250                 255     


Val Asp Leu Asn Leu Arg Asp Lys Gln Gly Lys Thr Ala Leu Ala Val 
            260                 265                 270         


Ala Val Arg Ser Asn His Val Ser Leu Val Asp Met Ile Ile Lys Ala 
        275                 280                 285             


Asp Arg Phe Tyr Arg Trp Glu Lys Asp His Pro Ser Asp Pro Ser Gly 
    290                 295                 300                 


Lys Ser Leu Ser Phe Lys Gln Asp His Arg Gln Glu Thr Gln Gln Leu 
305                 310                 315                 320 


Arg Ser Val Leu Trp Arg Leu Ala Ser Arg Tyr Leu Gln Pro Arg Glu 
                325                 330                 335     


Trp Lys Lys Leu Ala Tyr Ser Trp Glu Phe Thr Glu Ala His Val Asp 
            340                 345                 350         


Ala Ile Glu Gln Gln Trp Thr Gly Thr Arg Ser Tyr Gln Glu His Gly 
        355                 360                 365             


His Arg Met Leu Leu Ile Trp Leu His Gly Val Ala Thr Ala Gly Glu 
    370                 375                 380                 


Asn Pro Ser Lys Ala Leu Phe Glu Gly Leu Val Ala Ile Gly Arg Arg 
385                 390                 395                 400 


Asp Leu Ala Glu Asn Ile Arg Lys Lys Ala Asn Ala Ala Pro Ser Ala 
                405                 410                 415     


Pro Arg Arg Cys Thr Ala Met 
            420             


<210>  846
<211>  399
<212>  PRT
<213>  Homo Sapiens

<400>  846

Met Asn Ala Leu Leu Leu Ser Ala Trp Phe Gly His Leu Arg Ile Leu 
1               5                   10                  15      


Gln Ile Leu Val Asn Ser Gly Ala Lys Ile His Cys Glu Ser Lys Asp 
            20                  25                  30          


Gly Leu Thr Leu Leu His Cys Ala Ala Gln Lys Gly His Val Pro Val 
        35                  40                  45              


Leu Ala Phe Ile Met Glu Asp Leu Glu Asp Val Ala Leu Asp His Val 
    50                  55                  60                  


Asp Lys Leu Gly Arg Thr Ala Phe His Arg Ala Ala Glu His Gly Gln 
65                  70                  75                  80  


Leu Asp Ala Leu Asp Phe Leu Val Gly Ser Gly Cys Asp His Asn Val 
                85                  90                  95      


Lys Asp Lys Glu Gly Asn Thr Ala Leu His Leu Ala Ala Gly Arg Gly 
            100                 105                 110         


His Met Ala Val Leu Gln Arg Leu Val Asp Ile Gly Leu Asp Leu Glu 
        115                 120                 125             


Glu Gln Asn Ala Glu Gly Leu Thr Ala Leu His Ser Ala Ala Gly Gly 
    130                 135                 140                 


Ser His Pro Asp Cys Val Gln Leu Leu Leu Arg Ala Gly Ser Thr Val 
145                 150                 155                 160 


Asn Ala Leu Thr Gln Lys Asn Leu Ser Cys Leu His Tyr Ala Ala Leu 
                165                 170                 175     


Ser Gly Ser Glu Asp Val Ser Arg Val Leu Ile His Ala Gly Gly Cys 
            180                 185                 190         


Ala Asn Val Val Asp His Gln Gly Ala Ser Pro Leu His Leu Ala Val 
        195                 200                 205             


Arg His Asn Phe Pro Ala Leu Val Arg Leu Leu Ile Asn Ser Asp Ser 
    210                 215                 220                 


Asp Val Asn Ala Val Asp Asn Arg Gln Gln Thr Pro Leu His Leu Ala 
225                 230                 235                 240 


Ala Glu His Ala Trp Gln Asp Ile Ala Asp Met Leu Leu Ile Ala Gly 
                245                 250                 255     


Val Asp Leu Asn Leu Arg Asp Lys Asp His Pro Ser Asp Pro Ser Gly 
            260                 265                 270         


Lys Ser Leu Ser Phe Lys Gln Asp His Arg Gln Glu Thr Gln Gln Leu 
        275                 280                 285             


Arg Ser Val Leu Trp Arg Leu Ala Ser Arg Tyr Leu Gln Pro Arg Glu 
    290                 295                 300                 


Trp Lys Lys Leu Ala Tyr Ser Trp Glu Phe Thr Glu Ala His Val Asp 
305                 310                 315                 320 


Ala Ile Glu Gln Gln Trp Thr Gly Thr Arg Ser Tyr Gln Glu His Gly 
                325                 330                 335     


His Arg Met Leu Leu Ile Trp Leu His Gly Val Ala Thr Ala Gly Glu 
            340                 345                 350         


Asn Pro Ser Lys Ala Leu Phe Glu Gly Leu Val Ala Ile Gly Arg Arg 
        355                 360                 365             


Asp Leu Ala Gly Trp Ser Thr Met Ala Arg Ser Gln Leu Thr Ala Thr 
    370                 375                 380                 


Ser Ala Ser Arg Val Gln Met Ile Leu Val Pro Gln Pro Pro Glu 
385                 390                 395                 


<210>  847
<211>  423
<212>  PRT
<213>  Homo Sapiens

<400>  847

Met Asn Ala Leu Leu Leu Ser Ala Trp Phe Gly His Leu Arg Ile Leu 
1               5                   10                  15      


Gln Ile Leu Val Asn Ser Gly Ala Lys Ile His Cys Glu Ser Lys Asp 
            20                  25                  30          


Gly Leu Thr Leu Leu His Cys Ala Ala Gln Lys Gly His Val Pro Val 
        35                  40                  45              


Leu Ala Phe Ile Met Glu Asp Leu Glu Asp Val Ala Leu Asp His Val 
    50                  55                  60                  


Asp Lys Leu Gly Arg Thr Ala Phe His Arg Ala Ala Glu His Gly Gln 
65                  70                  75                  80  


Leu Asp Ala Leu Asp Phe Leu Val Gly Ser Gly Cys Asp His Asn Val 
                85                  90                  95      


Lys Asp Lys Glu Gly Asn Thr Ala Leu His Leu Ala Ala Gly Arg Gly 
            100                 105                 110         


His Met Ala Val Leu Gln Arg Leu Val Asp Ile Gly Leu Asp Leu Glu 
        115                 120                 125             


Glu Gln Asn Ala Glu Gly Leu Thr Ala Leu His Ser Ala Ala Gly Gly 
    130                 135                 140                 


Ser His Pro Asp Cys Val Gln Leu Leu Leu Arg Ala Gly Ser Thr Val 
145                 150                 155                 160 


Asn Ala Leu Thr Gln Lys Asn Leu Ser Cys Leu His Tyr Ala Ala Leu 
                165                 170                 175     


Ser Gly Ser Glu Asp Val Ser Arg Val Leu Ile His Ala Gly Gly Cys 
            180                 185                 190         


Ala Asn Val Val Asp His Gln Gly Ala Ser Pro Leu His Leu Ala Val 
        195                 200                 205             


Arg His Asn Phe Pro Ala Leu Val Arg Leu Leu Ile Asn Ser Asp Ser 
    210                 215                 220                 


Asp Val Asn Ala Val Asp Asn Arg Gln Gln Thr Pro Leu His Leu Ala 
225                 230                 235                 240 


Ala Glu His Ala Trp Gln Asp Ile Ala Asp Met Leu Leu Ile Ala Gly 
                245                 250                 255     


Val Asp Leu Asn Leu Arg Asp Lys Gln Gly Lys Thr Ala Leu Ala Val 
            260                 265                 270         


Ala Val Arg Ser Asn His Val Ser Leu Val Asp Met Ile Ile Lys Ala 
        275                 280                 285             


Asp Arg Phe Tyr Arg Trp Glu Lys Asp His Pro Ser Asp Pro Ser Gly 
    290                 295                 300                 


Lys Ser Leu Ser Phe Lys Gln Asp His Arg Gln Glu Thr Gln Gln Leu 
305                 310                 315                 320 


Arg Ser Val Leu Trp Arg Leu Ala Ser Arg Tyr Leu Gln Pro Arg Glu 
                325                 330                 335     


Trp Lys Lys Leu Ala Tyr Ser Trp Glu Phe Thr Glu Ala His Val Asp 
            340                 345                 350         


Ala Ile Glu Gln Gln Trp Thr Gly Thr Arg Ser Tyr Gln Glu His Gly 
        355                 360                 365             


His Arg Met Leu Leu Ile Trp Leu His Gly Val Ala Thr Ala Gly Glu 
    370                 375                 380                 


Asn Pro Ser Lys Ala Leu Phe Glu Gly Leu Val Ala Ile Gly Arg Arg 
385                 390                 395                 400 


Asp Leu Ala Glu Asn Ile Arg Lys Lys Ala Asn Ala Ala Pro Ser Ala 
                405                 410                 415     


Pro Arg Arg Cys Thr Ala Met 
            420             


<210>  848
<211>  181
<212>  PRT
<213>  Homo Sapiens

<400>  848

Met Asn Ala Leu Leu Leu Ser Ala Trp Phe Gly His Leu Arg Ile Leu 
1               5                   10                  15      


Gln Ile Leu Val Asn Ser Gly Ala Lys Ile His Cys Glu Ser Lys Asp 
            20                  25                  30          


Gly Leu Thr Leu Leu His Cys Ala Ala Gln Lys Gly His Val Pro Val 
        35                  40                  45              


Leu Ala Phe Ile Met Glu Asp Leu Glu Asp Val Ala Leu Asp His Val 
    50                  55                  60                  


Asp Lys Leu Gly Arg Thr Ala Phe His Arg Ala Ala Glu His Gly Gln 
65                  70                  75                  80  


Leu Asp Ala Leu Asp Phe Leu Val Gly Ser Gly Cys Asp His Asn Val 
                85                  90                  95      


Lys Asp Lys Glu Gly Asn Thr Ala Leu His Leu Ala Ala Gly Arg Gly 
            100                 105                 110         


His Met Ala Val Leu Gln Arg Leu Val Asp Ile Gly Leu Asp Leu Glu 
        115                 120                 125             


Glu Gln Asn Ala Glu Gly Leu Thr Ala Leu His Ser Ala Ala Gly Gly 
    130                 135                 140                 


Ser His Pro Asp Cys Val Gln Leu Leu Leu Arg Ala Gly Ser Thr Val 
145                 150                 155                 160 


Asn Ala Leu Thr Gln Val Ala Arg Pro Ser Gln Asp Cys Gly Arg Leu 
                165                 170                 175     


Leu Ala Ala Glu Pro 
            180     


<210>  849
<211>  123
<212>  PRT
<213>  Homo Sapiens

<400>  849

Met Gln Glu Glu Leu Ala Trp Glu Thr Asp Gly Leu Leu Pro Leu Glu 
1               5                   10                  15      


Arg Gln Leu His Glu Ala Ala Arg Gln Asn Asn Val Gly Arg Met Gln 
            20                  25                  30          


Glu Leu Ile Gly Arg Arg Val Asn Thr Arg Ala Arg Asn His Val Gly 
        35                  40                  45              


Arg Val Ala Leu His Trp Ala Ala Gly Ala Gly His Glu Gln Ala Val 
    50                  55                  60                  


Arg Leu Leu Leu Glu His Glu Ala Ala Val Asp Glu Glu Asp Ala Phe 
65                  70                  75                  80  


Gly Met Asn Ala Leu Leu Leu Ser Ala Trp Phe Gly His Leu Arg Ile 
                85                  90                  95      


Leu Gln Ile Leu Val Asn Ser Gly Ala Lys Ile His Cys Glu Ser Lys 
            100                 105                 110         


Pro Lys Lys Ala Met Cys Leu Cys Trp Arg Ser 
        115                 120             


<210>  850
<211>  522
<212>  PRT
<213>  Homo Sapiens

<400>  850

Met Gln Glu Glu Leu Ala Trp Glu Thr Asp Gly Leu Leu Pro Leu Glu 
1               5                   10                  15      


Arg Gln Leu His Glu Ala Ala Arg Gln Asn Asn Val Gly Arg Met Gln 
            20                  25                  30          


Glu Leu Ile Gly Arg Arg Val Asn Thr Arg Ala Arg Asn His Val Gly 
        35                  40                  45              


Arg Val Ala Leu His Trp Ala Ala Gly Ala Gly His Glu Gln Ala Val 
    50                  55                  60                  


Arg Leu Leu Leu Glu His Glu Ala Ala Val Asp Glu Glu Asp Ala Val 
65                  70                  75                  80  


Gly Ala Leu Thr Glu Ala Arg Leu Cys Phe Gly Met Asn Ala Leu Leu 
                85                  90                  95      


Leu Ser Ala Trp Phe Gly His Leu Arg Ile Leu Gln Ile Leu Val Asn 
            100                 105                 110         


Ser Gly Ala Lys Ile His Cys Glu Ser Lys Asp Gly Leu Thr Leu Leu 
        115                 120                 125             


His Cys Ala Ala Gln Lys Gly His Val Pro Val Leu Ala Phe Ile Met 
    130                 135                 140                 


Glu Asp Leu Glu Asp Val Ala Leu Asp His Val Asp Lys Leu Gly Arg 
145                 150                 155                 160 


Thr Ala Phe His Arg Ala Ala Glu His Gly Gln Leu Asp Ala Leu Asp 
                165                 170                 175     


Phe Leu Val Gly Ser Gly Cys Asp His Asn Val Lys Asp Lys Glu Gly 
            180                 185                 190         


Asn Thr Ala Leu His Leu Ala Ala Gly Arg Gly His Met Ala Val Leu 
        195                 200                 205             


Gln Arg Leu Val Asp Ile Gly Leu Asp Leu Glu Glu Gln Asn Ala Glu 
    210                 215                 220                 


Gly Leu Thr Ala Leu His Ser Ala Ala Gly Gly Ser His Pro Asp Cys 
225                 230                 235                 240 


Val Gln Leu Leu Leu Arg Ala Gly Ser Thr Val Asn Ala Leu Thr Gln 
                245                 250                 255     


Lys Asn Leu Ser Cys Leu His Tyr Ala Ala Leu Ser Gly Ser Glu Asp 
            260                 265                 270         


Val Ser Arg Val Leu Ile His Ala Gly Gly Cys Ala Asn Val Val Asp 
        275                 280                 285             


His Gln Gly Ala Ser Pro Leu His Leu Ala Val Arg His Asn Phe Pro 
    290                 295                 300                 


Ala Leu Val Arg Leu Leu Ile Asn Ser Asp Ser Asp Val Asn Ala Val 
305                 310                 315                 320 


Asp Asn Arg Gln Gln Thr Pro Leu His Leu Ala Ala Glu His Ala Trp 
                325                 330                 335     


Gln Asp Ile Ala Asp Met Leu Leu Ile Ala Gly Val Asp Leu Asn Leu 
            340                 345                 350         


Arg Asp Lys Gln Gly Lys Thr Ala Leu Ala Val Ala Val Arg Ser Asn 
        355                 360                 365             


His Val Ser Leu Val Asp Met Ile Ile Lys Ala Asp Arg Phe Tyr Arg 
    370                 375                 380                 


Trp Glu Lys Asp His Pro Ser Asp Pro Ser Gly Lys Ser Leu Ser Phe 
385                 390                 395                 400 


Lys Gln Asp His Arg Gln Glu Thr Gln Gln Leu Arg Ser Val Leu Trp 
                405                 410                 415     


Arg Leu Ala Ser Arg Tyr Leu Gln Pro Arg Glu Trp Lys Lys Leu Ala 
            420                 425                 430         


Tyr Ser Trp Glu Phe Thr Glu Ala His Val Asp Ala Ile Glu Gln Gln 
        435                 440                 445             


Trp Thr Gly Thr Arg Ser Tyr Gln Glu His Gly His Arg Met Leu Leu 
    450                 455                 460                 


Ile Trp Leu His Gly Val Ala Thr Ala Gly Glu Asn Pro Ser Lys Ala 
465                 470                 475                 480 


Leu Phe Glu Gly Leu Val Ala Ile Gly Arg Arg Asp Leu Ala Gly Trp 
                485                 490                 495     


Ser Thr Met Ala Arg Ser Gln Leu Thr Ala Thr Ser Ala Ser Arg Val 
            500                 505                 510         


Gln Met Ile Leu Val Pro Gln Pro Pro Glu 
        515                 520         


<210>  851
<211>  217
<212>  PRT
<213>  Homo Sapiens

<400>  851

Met Ala Ala Ala Ala Gly Asp Ala Asp Asp Glu Pro Arg Ser Gly His 
1               5                   10                  15      


Ser Ser Ser Glu Gly Glu Cys Ala Val Ala Pro Glu Pro Leu Thr Asp 
            20                  25                  30          


Ala Glu Gly Leu Phe Ser Phe Ala Asp Phe Gly Ser Ala Leu Gly Gly 
        35                  40                  45              


Gly Gly Ala Gly Leu Ser Gly Arg Ala Ser Gly Gly Ala Gln Ser Pro 
    50                  55                  60                  


Leu Arg Tyr Leu His Val Leu Trp Gln Gln Asp Ala Glu Pro Arg Asp 
65                  70                  75                  80  


Glu Leu Arg Cys Lys Ile Pro Ala Gly Arg Leu Arg Arg Ala Ala Arg 
                85                  90                  95      


Pro His Arg Arg Leu Gly Pro Thr Gly Lys Glu Val His Ala Leu Lys 
            100                 105                 110         


Arg Leu Arg Asp Ser Ala Asn Ala Asn Asp Val Glu Thr Val Gln Gln 
        115                 120                 125             


Leu Leu Glu Asp Gly Ala Asp Pro Cys Ala Ala Asp Asp Lys Gly Arg 
    130                 135                 140                 


Thr Ala Leu His Phe Ala Ser Cys Asn Gly Asn Asp Gln Ile Val Gln 
145                 150                 155                 160 


Leu Leu Leu Asp His Gly Ala Asp Pro Asn Gln Arg Asp Gly Leu Gly 
                165                 170                 175     


Asn Thr Pro Leu His Leu Ala Ala Cys Thr Asn His Val Pro Val Ile 
            180                 185                 190         


Thr Thr Leu Leu Arg Gly Ala Gly Thr Cys Arg Gly Pro Cys Arg Cys 
        195                 200                 205             


Pro Gly Pro Ser Trp Ser His Thr Pro 
    210                 215         


<210>  852
<211>  300
<212>  PRT
<213>  Homo Sapiens

<400>  852

Met Ala Ala Ala Ala Gly Asp Ala Asp Asp Glu Pro Arg Ser Gly His 
1               5                   10                  15      


Ser Ser Ser Glu Gly Glu Cys Ala Val Ala Pro Glu Pro Leu Thr Asp 
            20                  25                  30          


Ala Glu Gly Leu Phe Ser Phe Ala Asp Phe Gly Ser Ala Leu Gly Gly 
        35                  40                  45              


Gly Gly Ala Gly Leu Ser Gly Arg Ala Ser Gly Gly Ala Gln Ser Pro 
    50                  55                  60                  


Leu Arg Tyr Leu His Val Leu Trp Gln Gln Asp Ala Glu Pro Arg Asp 
65                  70                  75                  80  


Glu Leu Arg Cys Lys Ile Pro Ala Gly Arg Leu Arg Arg Ala Ala Arg 
                85                  90                  95      


Pro His Arg Arg Leu Gly Pro Thr Gly Lys Glu Val His Ala Leu Lys 
            100                 105                 110         


Arg Leu Arg Asp Ser Ala Asn Ala Asn Asp Val Glu Thr Val Gln Gln 
        115                 120                 125             


Leu Leu Glu Asp Gly Ala Asp Pro Cys Ala Ala Asp Asp Lys Gly Arg 
    130                 135                 140                 


Thr Ala Leu His Phe Ala Ser Cys Asn Gly Asn Asp Gln Ile Val Gln 
145                 150                 155                 160 


Leu Leu Leu Asp His Gly Ala Asp Pro Asn Gln Arg Asp Gly Leu Gly 
                165                 170                 175     


Asn Thr Pro Leu His Leu Ala Ala Cys Thr Asn His Val Pro Val Ile 
            180                 185                 190         


Thr Thr Leu Leu Arg Gly Gly Ala Arg Val Asp Ala Leu Asp Arg Ala 
        195                 200                 205             


Gly Arg Thr Pro Leu His Leu Ala Lys Ser Lys Leu Asn Ile Leu Gln 
    210                 215                 220                 


Glu Gly His Ala Gln Cys Leu Glu Ala Val Arg Leu Glu Val Lys Gln 
225                 230                 235                 240 


Ile Ile His Met Leu Arg Glu Tyr Leu Glu Arg Leu Gly Gln His Glu 
                245                 250                 255     


Gln Arg Glu Arg Leu Asp Asp Leu Cys Thr Arg Leu Gln Met Thr Ser 
            260                 265                 270         


Thr Lys Glu Gln Val Asp Glu Val Thr Asp Leu Leu Ala Ser Phe Thr 
        275                 280                 285             


Ser Leu Ser Leu Gln Met Gln Ser Met Glu Lys Arg 
    290                 295                 300 


<210>  853
<211>  284
<212>  PRT
<213>  Homo Sapiens

<400>  853

Met Ala Ala Ala Ala Gly Asp Ala Asp Asp Glu Pro Arg Ser Gly His 
1               5                   10                  15      


Ser Ser Ser Glu Gly Glu Cys Ala Val Ala Pro Glu Pro Leu Thr Asp 
            20                  25                  30          


Ala Glu Gly Leu Phe Ser Phe Ala Asp Phe Gly Ser Ala Leu Gly Gly 
        35                  40                  45              


Gly Gly Ala Gly Leu Ser Gly Arg Ala Ser Gly Gly Ala Gln Ser Pro 
    50                  55                  60                  


Leu Arg Tyr Leu His Val Leu Trp Gln Gln Asp Ala Glu Pro Arg Asp 
65                  70                  75                  80  


Glu Leu Arg Cys Lys Ile Pro Ala Gly Arg Leu Arg Arg Ala Ala Arg 
                85                  90                  95      


Pro His Arg Arg Leu Gly Pro Thr Gly Lys Glu Val His Val Gln Gln 
            100                 105                 110         


Leu Leu Glu Asp Gly Ala Asp Pro Cys Ala Ala Asp Asp Lys Gly Arg 
        115                 120                 125             


Thr Ala Leu His Phe Ala Ser Cys Asn Gly Asn Asp Gln Ile Val Gln 
    130                 135                 140                 


Leu Leu Leu Asp His Gly Ala Asp Pro Asn Gln Arg Asp Gly Leu Gly 
145                 150                 155                 160 


Asn Thr Pro Leu His Leu Ala Ala Cys Thr Asn His Val Pro Val Ile 
                165                 170                 175     


Thr Thr Leu Leu Arg Gly Gly Ala Arg Val Asp Ala Leu Asp Arg Ala 
            180                 185                 190         


Gly Arg Thr Pro Leu His Leu Ala Lys Ser Lys Leu Asn Ile Leu Gln 
        195                 200                 205             


Glu Gly His Ala Gln Cys Leu Glu Ala Val Arg Leu Glu Val Lys Gln 
    210                 215                 220                 


Ile Ile His Met Leu Arg Glu Tyr Leu Glu Arg Leu Gly Gln His Glu 
225                 230                 235                 240 


Gln Arg Glu Arg Leu Asp Asp Leu Cys Thr Arg Leu Gln Met Thr Ser 
                245                 250                 255     


Thr Lys Glu Gln Val Asp Glu Val Thr Asp Leu Leu Ala Ser Phe Thr 
            260                 265                 270         


Ser Leu Ser Leu Gln Met Gln Ser Met Glu Lys Arg 
        275                 280                 


<210>  854
<211>  90
<212>  PRT
<213>  Homo Sapiens

<400>  854

Met Ala Arg Ile Pro Val Gln Leu Met Thr Arg Ala Ala Gln Leu Tyr 
1               5                   10                  15      


Thr Leu Pro His Ala Met Ala Met Thr Arg Leu Leu Leu Leu Asp His 
            20                  25                  30          


Gly Ala Asp Pro Asn Gln Arg Asp Gly Leu Gly Asn Thr Pro Leu His 
        35                  40                  45              


Leu Ala Ala Cys Thr Asn His Val Pro Val Ile Thr Thr Leu Leu Arg 
    50                  55                  60                  


Gly Gly Ala Arg Val Asp Ala Leu Asp Arg Ala Gly Arg Thr Pro Leu 
65                  70                  75                  80  


His Leu Ala Lys Ser Lys Leu Asn Ile Leu 
                85                  90  


<210>  855
<211>  156
<212>  PRT
<213>  Homo Sapiens

<400>  855

Met Ala Arg Ile Pro Val Gln Leu Met Thr Arg Ala Ala Gln Leu Tyr 
1               5                   10                  15      


Thr Leu Pro His Ala Met Ala Met Thr Arg Leu Leu Leu Leu Asp His 
            20                  25                  30          


Gly Ala Asp Pro Asn Gln Arg Asp Gly Leu Gly Asn Thr Pro Leu His 
        35                  40                  45              


Leu Ala Ala Cys Thr Asn His Val Pro Val Ile Thr Thr Leu Leu Arg 
    50                  55                  60                  


Gly Gly Ala Arg Val Asp Ala Leu Asp Arg Ala Gly Arg Thr Pro Leu 
65                  70                  75                  80  


His Leu Ala Lys Ser Lys Leu Asn Ile Leu Gln Glu Gly His Ala Gln 
                85                  90                  95      


Cys Leu Glu Ala Val Arg Leu Glu Val Lys Gln Ile Ile His Met Leu 
            100                 105                 110         


Arg Glu Tyr Leu Glu Arg Leu Gly Gln His Glu Gln Arg Glu Arg Leu 
        115                 120                 125             


Asp Asp Leu Cys Thr Arg Leu Gln Met Thr Ser Thr Lys Glu Gln Val 
    130                 135                 140                 


Asp Glu Val Thr Asp Leu Leu Ala Ser Phe Thr Ser 
145                 150                 155     


<210>  856
<211>  107
<212>  PRT
<213>  Homo Sapiens

<400>  856

Met Pro Met Met Trp Lys Gln Cys Ser Cys Ser Trp Thr Met Val Leu 
1               5                   10                  15      


Ile Leu Thr Ser Glu Met Gly Trp Gly Thr Arg His Cys Thr Trp Arg 
            20                  25                  30          


Pro Ala Pro Thr Thr Phe Leu Ser Ser Pro His Cys Tyr Glu Glu Ile 
        35                  40                  45              


Ile His Met Leu Arg Glu Tyr Leu Glu Arg Leu Gly Gln His Glu Gln 
    50                  55                  60                  


Arg Glu Arg Leu Asp Asp Leu Cys Thr Arg Leu Gln Met Thr Ser Thr 
65                  70                  75                  80  


Lys Glu Gln Val Asp Glu Val Thr Asp Leu Leu Ala Ser Phe Thr Ser 
                85                  90                  95      


Leu Ser Leu Gln Met Gln Ser Met Glu Lys Arg 
            100                 105         


<210>  857
<211>  180
<212>  PRT
<213>  Homo Sapiens

<400>  857

Met Pro Met Met Trp Lys Gln Gln Leu Leu Glu Asp Gly Ala Asp Pro 
1               5                   10                  15      


Cys Ala Ala Asp Asp Lys Gly Arg Thr Ala Leu His Phe Ala Ser Cys 
            20                  25                  30          


Asn Gly Asn Asp Gln Ile Val Gln Leu Leu Leu Asp His Gly Ala Asp 
        35                  40                  45              


Pro Asn Gln Arg Asp Gly Leu Gly Asn Thr Pro Leu His Leu Ala Ala 
    50                  55                  60                  


Cys Thr Asn His Val Pro Val Ile Thr Thr Leu Leu Arg Gly Gly Ala 
65                  70                  75                  80  


Arg Val Asp Ala Leu Asp Arg Ala Gly Arg Thr Pro Leu His Leu Ala 
                85                  90                  95      


Lys Ser Lys Leu Asn Ile Leu Gln Glu Gly His Ala Gln Cys Leu Glu 
            100                 105                 110         


Ala Val Arg Leu Glu Val Lys Gln Ile Ile His Met Leu Arg Glu Tyr 
        115                 120                 125             


Leu Glu Arg Leu Gly Gln His Glu Gln Arg Glu Arg Leu Asp Asp Leu 
    130                 135                 140                 


Cys Thr Arg Leu Gln Met Thr Ser Thr Lys Glu Gln Val Asp Glu Val 
145                 150                 155                 160 


Thr Asp Leu Leu Ala Ser Phe Thr Ser Leu Ser Leu Gln Met Gln Ser 
                165                 170                 175     


Met Glu Lys Arg 
            180 


<210>  858
<211>  208
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  858

Xaa Arg Asp Glu Leu Arg Cys Lys Ile Pro Ala Gly Arg Leu Arg Arg 
1               5                   10                  15      


Ala Ala Arg Pro His Arg Arg Leu Gly Pro Thr Gly Lys Glu Val His 
            20                  25                  30          


Ala Leu Lys Arg Leu Arg Asp Ser Ala Asn Ala Asn Asp Val Glu Thr 
        35                  40                  45              


Val Gln Gln Leu Leu Glu Asp Gly Ala Asp Pro Cys Ala Ala Asp Asp 
    50                  55                  60                  


Lys Gly Arg Thr Ala Leu His Phe Ala Ser Cys Asn Gly Asn Asp Gln 
65                  70                  75                  80  


Ile Val Gln Leu Leu Leu Asp His Gly Ala Asp Pro Asn Gln Arg Asp 
                85                  90                  95      


Gly Leu Gly Asn Thr Pro Leu His Leu Glu Cys Ser Pro Gln Leu Val 
            100                 105                 110         


Pro Ala Gly Ala Arg Val Asp Ala Leu Asp Arg Ala Gly Arg Thr Pro 
        115                 120                 125             


Leu His Leu Ala Lys Ser Lys Leu Asn Ile Leu Gln Glu Gly His Ala 
    130                 135                 140                 


Gln Cys Leu Glu Ala Val Arg Leu Glu Val Lys Gln Ile Ile His Met 
145                 150                 155                 160 


Leu Arg Glu Tyr Leu Glu Arg Leu Gly Gln His Glu Gln Arg Glu Arg 
                165                 170                 175     


Leu Asp Asp Leu Cys Thr Arg Leu Gln Met Thr Ser Thr Lys Glu Gln 
            180                 185                 190         


Val Asp Glu Val Thr Asp Leu Leu Ala Ser Phe Thr Ser Leu Ser Leu 
        195                 200                 205             


<210>  859
<211>  178
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  859

Xaa Arg Leu Arg Arg Pro Gly Pro Arg Gly Ala Val Ala Met Ala Ala 
1               5                   10                  15      


Ala Ala Gly Asp Ala Asp Asp Glu Pro Arg Ser Gly His Ser Ser Ser 
            20                  25                  30          


Glu Gly Glu Cys Ala Val Ala Pro Glu Pro Leu Thr Asp Ala Glu Gly 
        35                  40                  45              


Leu Phe Ser Phe Ala Asp Phe Gly Ser Ala Leu Gly Gly Gly Gly Ala 
    50                  55                  60                  


Gly Leu Ser Gly Arg Ala Ser Gly Gly Ala Gln Ser Pro Leu Arg Tyr 
65                  70                  75                  80  


Leu His Val Leu Trp Gln Gln Asp Ala Glu Pro Arg Asp Glu Leu Arg 
                85                  90                  95      


Cys Lys Ile Pro Ala Gly Arg Leu Arg Arg Ala Ala Arg Pro His Arg 
            100                 105                 110         


Arg Leu Gly Pro Thr Gly Lys Glu Val His Ala Leu Lys Arg Leu Arg 
        115                 120                 125             


Asp Ser Ala Asn Ala Asn Asp Val Glu Thr Val Gln Gln Leu Leu Glu 
    130                 135                 140                 


Asp Gly Ala Asp Pro Cys Ala Ala Asp Asp Lys Gly Arg Thr Ala Leu 
145                 150                 155                 160 


His Phe Ala Ser Cys Asn Gly Asn Asp Gln Ile Ala Ala Pro Gly Pro 
                165                 170                 175     


Trp Cys 
        


<210>  860
<211>  345
<212>  PRT
<213>  Homo Sapiens

<400>  860

Met Thr Arg Gly Arg Ala Trp Gly Met Arg Arg Ala Ala Ala Gly Ala 
1               5                   10                  15      


Gly Gly Ala Arg Ala Ala Gly Pro Thr Gly Gly Ala Ser Arg Leu His 
            20                  25                  30          


Pro Asn Ala Gly Arg Arg Ser Gly Ala Arg Ala Gly Ala Gln Gly Cys 
        35                  40                  45              


Gly Gly Pro Arg Val Gly Ser Ala Asp Ser Arg Ala Leu Pro Ala Gln 
    50                  55                  60                  


Pro Leu Ala Cys Ala Arg Gly Arg Ser Gln Arg Leu Val Cys Asp Pro 
65                  70                  75                  80  


Lys Ala Ala Ser Ala Leu Pro Asp Leu Ala Pro Asp Val Phe Val Leu 
                85                  90                  95      


Arg Val Arg Leu Glu Glu Thr Gly Glu Met Phe Arg Val Ala Asn Cys 
            100                 105                 110         


Arg Gly Asp Met Thr Val Arg Glu Leu Lys Glu Glu Leu Asp Leu Met 
        115                 120                 125             


Val Gly Ile Pro Phe Asn Leu Gln Arg Leu Gln Tyr Leu Asp Glu Gly 
    130                 135                 140                 


Val Leu Met Asp Asp Thr Thr Leu Lys Phe His Asp Val Val Pro Gly 
145                 150                 155                 160 


Gly Ile Ile Ser Leu Cys Ile Trp His His Asp Gly Trp Thr Glu Leu 
                165                 170                 175     


Val Leu Ala Ala Val Glu Gly Asp Pro Ser Lys Leu Ser Cys Leu Gly 
            180                 185                 190         


Leu Thr Glu Asp Ser Phe Tyr Arg Thr Ala Asn Ser Glu His Phe Glu 
        195                 200                 205             


Gly Glu Lys Trp Lys His Trp Thr Ser Gln Arg Ala Phe Val Ala Leu 
    210                 215                 220                 


Tyr Val Ala Ser His Arg Gly His Phe Asp Ala Val Gln Tyr Leu Leu 
225                 230                 235                 240 


Glu His Gly Ala Ser Cys Leu Ser Arg Ser Pro Leu Gly Arg Thr Pro 
                245                 250                 255     


Leu His Val Ala Ala Ala Met Gly Arg Ser Asp Cys Ile Ile Leu Leu 
            260                 265                 270         


Leu Gln His Gly Ala Ser Ile His Asp Arg Asp Ala Lys Gly Glu Thr 
        275                 280                 285             


Pro Ile Ser Ile Ala His Arg Leu Asn His Thr Leu Ser Glu Arg Gln 
    290                 295                 300                 


Met Val Leu Leu His Arg Ile Ala Lys Ser Gly Ile Arg Asp Leu Asn 
305                 310                 315                 320 


Asp Leu Val Met Lys Asn Ala Leu Gln Arg Val Lys Ser Gly Phe Arg 
                325                 330                 335     


Ser Glu Lys Met Thr Met Thr Pro His 
            340                 345 


<210>  861
<211>  933
<212>  PRT
<213>  Homo Sapiens

<400>  861

Met Arg Met Ala Ala Thr Ala Trp Ala Gly Leu Gln Gly Pro Pro Leu 
1               5                   10                  15      


Pro Thr Leu Cys Pro Ala Val Arg Thr Gly Leu Tyr Cys Arg Asp Gln 
            20                  25                  30          


Ala His Ala Glu Arg Trp Ala Met Thr Ser Glu Thr Ser Ser Gly Ser 
        35                  40                  45              


His Cys Ala Arg Ser Arg Met Leu Arg Arg Arg Ala Gln Glu Glu Asp 
    50                  55                  60                  


Ser Thr Val Leu Ile Asp Val Ser Pro Pro Glu Ala Glu Lys Arg Gly 
65                  70                  75                  80  


Ser Tyr Gly Ser Thr Ala His Ala Ser Glu Pro Gly Gly Gln Gln Ala 
                85                  90                  95      


Ala Ala Cys Arg Ala Gly Ser Pro Ala Lys Pro Arg Ile Ala Asp Phe 
            100                 105                 110         


Val Leu Val Trp Glu Glu Asp Leu Lys Leu Asp Arg Gln Gln Asp Ser 
        115                 120                 125             


Ala Ala Arg Asp Arg Thr Asp Met His Arg Thr Trp Arg Glu Thr Phe 
    130                 135                 140                 


Leu Asp Asn Leu Arg Ala Ala Gly Leu Cys Val Asp Gln Gln Asp Val 
145                 150                 155                 160 


Gln Asp Gly Asn Thr Thr Val His Tyr Ala Leu Leu Ser Ala Ser Trp 
                165                 170                 175     


Ala Val Leu Cys Tyr Tyr Ala Glu Asp Leu Arg Leu Lys Leu Pro Leu 
            180                 185                 190         


Gln Glu Leu Pro Asn Gln Ala Ser Asn Trp Ser Ala Gly Leu Leu Ala 
        195                 200                 205             


Trp Leu Gly Ile Pro Asn Val Leu Leu Glu Val Val Pro Asp Val Pro 
    210                 215                 220                 


Pro Glu Tyr Tyr Ser Cys Arg Phe Arg Val Asn Lys Leu Pro Arg Phe 
225                 230                 235                 240 


Leu Gly Ser Asp Asn Gln Asp Thr Phe Phe Thr Ser Thr Lys Arg His 
                245                 250                 255     


Gln Ile Leu Phe Glu Ile Leu Ala Lys Thr Pro Tyr Gly His Glu Lys 
            260                 265                 270         


Lys Asn Leu Leu Gly Ile His Gln Leu Leu Ala Glu Gly Val Leu Ser 
        275                 280                 285             


Ala Ala Phe Pro Leu His Asp Gly Pro Phe Lys Thr Pro Pro Glu Gly 
    290                 295                 300                 


Pro Gln Ala Pro Arg Leu Asn Gln Arg Gln Val Leu Phe Gln His Trp 
305                 310                 315                 320 


Ala Arg Trp Gly Lys Trp Asn Lys Tyr Gln Pro Leu Asp His Val Arg 
                325                 330                 335     


Arg Tyr Phe Gly Glu Lys Val Ala Leu Tyr Phe Ala Trp Leu Gly Phe 
            340                 345                 350         


Tyr Thr Gly Trp Leu Leu Pro Ala Ala Val Val Gly Thr Leu Val Phe 
        355                 360                 365             


Leu Val Gly Cys Phe Leu Val Phe Ser Asp Ile Pro Thr Gln Glu Leu 
    370                 375                 380                 


Cys Gly Ser Lys Asp Ser Phe Glu Met Cys Pro Leu Cys Leu Asp Cys 
385                 390                 395                 400 


Pro Phe Trp Leu Leu Ser Ser Ala Cys Ala Leu Ala Gln Ala Gly Arg 
                405                 410                 415     


Leu Phe Asp His Gly Gly Thr Val Phe Phe Ser Leu Phe Met Ala Leu 
            420                 425                 430         


Trp Ala Val Leu Leu Leu Glu Tyr Trp Lys Arg Lys Ser Ala Thr Leu 
        435                 440                 445             


Ala Tyr Arg Trp Asp Cys Ser Asp Tyr Glu Asp Thr Glu Glu Arg Pro 
    450                 455                 460                 


Arg Pro Gln Phe Ala Ala Ser Ala Pro Met Thr Ala Pro Asn Pro Ile 
465                 470                 475                 480 


Thr Gly Glu Asp Glu Pro Tyr Phe Pro Glu Arg Ser Arg Ala Arg Arg 
                485                 490                 495     


Met Leu Ala Gly Ser Val Val Ile Val Val Met Val Ala Val Val Val 
            500                 505                 510         


Met Cys Leu Val Ser Ile Ile Leu Tyr Arg Ala Ile Met Ala Ile Val 
        515                 520                 525             


Val Ser Arg Ser Gly Asn Thr Leu Leu Ala Ala Trp Ala Ser Arg Ile 
    530                 535                 540                 


Ala Ser Leu Thr Gly Ser Val Val Asn Leu Val Phe Ile Leu Ile Leu 
545                 550                 555                 560 


Ser Lys Ile Tyr Val Ser Leu Ala His Val Leu Thr Arg Trp Glu Met 
                565                 570                 575     


His Arg Thr Gln Thr Lys Phe Glu Asp Ala Phe Thr Leu Lys Val Phe 
            580                 585                 590         


Ile Phe Gln Phe Val Asn Phe Tyr Ser Ser Pro Val Tyr Ile Ala Phe 
        595                 600                 605             


Phe Lys Gly Arg Phe Val Gly Tyr Pro Gly Asn Tyr His Thr Leu Phe 
    610                 615                 620                 


Gly Val Arg Asn Glu Glu Cys Ala Ala Gly Gly Cys Leu Ile Glu Leu 
625                 630                 635                 640 


Ala Gln Glu Leu Leu Val Ile Met Val Gly Lys Gln Val Ile Asn Asn 
                645                 650                 655     


Met Gln Glu Val Leu Ile Pro Lys Leu Lys Gly Trp Trp Gln Lys Phe 
            660                 665                 670         


Arg Leu Arg Ser Lys Lys Arg Lys Ala Gly Ala Ser Ala Gly Ala Ser 
        675                 680                 685             


Gln Gly Pro Trp Glu Asp Asp Tyr Glu Leu Val Pro Cys Glu Gly Leu 
    690                 695                 700                 


Phe Asp Glu Tyr Leu Glu Met Val Leu Gln Phe Gly Phe Val Thr Ile 
705                 710                 715                 720 


Phe Val Ala Ala Cys Pro Leu Ala Pro Leu Phe Ala Leu Leu Asn Asn 
                725                 730                 735     


Trp Val Glu Ile Arg Leu Asp Ala Arg Lys Phe Val Cys Glu Tyr Arg 
            740                 745                 750         


Arg Pro Val Ala Glu Arg Ala Gln Asp Ile Gly Ile Trp Phe His Ile 
        755                 760                 765             


Leu Ala Gly Leu Thr His Leu Ala Val Ile Ser Asn Ala Phe Leu Leu 
    770                 775                 780                 


Ala Phe Ser Ser Asp Phe Leu Pro Arg Ala Tyr Tyr Arg Trp Thr Arg 
785                 790                 795                 800 


Ala His Asp Leu Arg Gly Phe Leu Asn Phe Thr Leu Ala Arg Ala Pro 
                805                 810                 815     


Ser Ser Phe Ala Ala Ala His Asn Arg Thr Cys Arg Tyr Arg Ala Phe 
            820                 825                 830         


Arg Asp Asp Asp Gly His Tyr Ser Gln Thr Tyr Trp Asn Leu Leu Ala 
        835                 840                 845             


Ile Arg Leu Ala Phe Val Ile Val Phe Glu His Val Val Phe Ser Val 
    850                 855                 860                 


Gly Arg Leu Leu Asp Leu Leu Val Pro Asp Ile Pro Glu Ser Val Glu 
865                 870                 875                 880 


Ile Lys Val Lys Arg Glu Tyr Tyr Leu Ala Lys Gln Ala Leu Ala Glu 
                885                 890                 895     


Asn Glu Val Leu Phe Gly Thr Asn Gly Thr Lys Asp Glu Gln Pro Glu 
            900                 905                 910         


Gly Ser Glu Leu Ser Ser His Trp Thr Pro Phe Thr Val Pro Lys Ala 
        915                 920                 925             


Ser Gln Leu Gln Gln 
    930             


<210>  862
<211>  883
<212>  PRT
<213>  Homo Sapiens

<400>  862

Met Arg Met Ala Ala Thr Ala Trp Ala Gly Leu Gln Gly Pro Pro Leu 
1               5                   10                  15      


Pro Thr Leu Cys Pro Ala Val Arg Thr Gly Leu Tyr Cys Arg Asp Gln 
            20                  25                  30          


Ala His Ala Glu Arg Trp Ala Met Thr Ser Glu Thr Ser Ser Gly Ser 
        35                  40                  45              


His Cys Ala Arg Ser Arg Met Leu Arg Arg Arg Ala Gln Glu Glu Asp 
    50                  55                  60                  


Ser Thr Val Leu Ile Asp Val Ser Pro Pro Glu Ala Glu Lys Arg Gly 
65                  70                  75                  80  


Ser Tyr Gly Ser Thr Ala His Ala Ser Glu Pro Gly Gly Gln Gln Ala 
                85                  90                  95      


Ala Ala Cys Arg Ala Gly Ser Pro Ala Lys Pro Arg Ile Asp Phe Val 
            100                 105                 110         


Leu Val Trp Glu Glu Asp Leu Lys Leu Asp Arg Gln Gln Asp Ser Ala 
        115                 120                 125             


Ala Arg Asp Arg Thr Asp Met His Arg Thr Trp Arg Glu Thr Phe Leu 
    130                 135                 140                 


Asp Asn Leu Arg Ala Ala Gly Leu Cys Val Asp Gln Gln Asp Val Gln 
145                 150                 155                 160 


Asp Gly Asn Thr Thr Val His Tyr Ala Leu Leu Ser Ala Ser Trp Ala 
                165                 170                 175     


Val Leu Cys Tyr Tyr Ala Glu Asp Leu Arg Leu Lys Leu Pro Leu Gln 
            180                 185                 190         


Glu Leu Pro Asn Gln Ala Ser Asn Trp Ser Ala Gly Leu Leu Ala Trp 
        195                 200                 205             


Leu Gly Ile Pro Asn Val Leu Leu Glu Val Val Pro Asp Val Pro Pro 
    210                 215                 220                 


Glu Tyr Tyr Ser Cys Arg Phe Arg Val Asn Lys Leu Pro Arg Phe Leu 
225                 230                 235                 240 


Gly Ser Asp Asn Gln Asp Thr Phe Phe Thr Ser Thr Lys Arg His Gln 
                245                 250                 255     


Ile Leu Phe Glu Ile Leu Ala Lys Thr Pro Tyr Gly His Glu Lys Lys 
            260                 265                 270         


Asn Leu Leu Gly Ile His Gln Leu Leu Ala Glu Gly Val Leu Ser Ala 
        275                 280                 285             


Ala Phe Pro Leu His Asp Gly Pro Phe Lys Thr Pro Pro Glu Gly Pro 
    290                 295                 300                 


Gln Ala Pro Arg Leu Asn Gln Arg Gln Val Leu Phe Gln His Trp Ala 
305                 310                 315                 320 


Arg Trp Gly Lys Trp Asn Lys Tyr Gln Pro Leu Asp His Val Arg Arg 
                325                 330                 335     


Tyr Phe Gly Glu Lys Val Ala Leu Tyr Phe Ala Trp Leu Gly Phe Tyr 
            340                 345                 350         


Thr Gly Trp Leu Leu Pro Ala Ala Val Val Gly Thr Leu Val Phe Leu 
        355                 360                 365             


Val Gly Cys Phe Leu Val Phe Ser Asp Ile Pro Thr Gln Glu Leu Cys 
    370                 375                 380                 


Gly Ser Lys Asp Ser Phe Glu Met Cys Pro Leu Cys Leu Asp Cys Pro 
385                 390                 395                 400 


Phe Trp Leu Leu Ser Ser Ala Cys Ala Leu Ala Gln Ala Gly Arg Leu 
                405                 410                 415     


Phe Asp His Gly Gly Thr Val Phe Phe Ser Leu Phe Met Ala Leu Trp 
            420                 425                 430         


Ala Val Leu Leu Leu Glu Tyr Trp Lys Arg Lys Ser Ala Thr Leu Ala 
        435                 440                 445             


Tyr Arg Trp Asp Cys Ser Asp Tyr Glu Asp Thr Glu Glu Arg Pro Arg 
    450                 455                 460                 


Pro Gln Phe Ala Ala Ser Ala Pro Met Thr Ala Pro Asn Pro Ile Thr 
465                 470                 475                 480 


Gly Glu Asp Glu Pro Tyr Phe Pro Glu Arg Ser Arg Ala Arg Arg Met 
                485                 490                 495     


Leu Ala Gly Ser Val Val Ile Val Val Met Val Ala Val Val Val Met 
            500                 505                 510         


Cys Leu Val Ser Ile Ile Leu Tyr Arg Ala Ile Met Ala Ile Val Val 
        515                 520                 525             


Ser Arg Ser Gly Asn Thr Leu Leu Ala Ala Trp Ala Ser Arg Ile Ala 
    530                 535                 540                 


Ser Leu Thr Gly Ser Val Val Asn Leu Val Phe Ile Leu Ile Leu Ser 
545                 550                 555                 560 


Lys Ile Tyr Val Ser Leu Ala His Val Leu Thr Arg Trp Glu Met His 
                565                 570                 575     


Arg Thr Gln Thr Lys Phe Glu Asp Ala Phe Thr Leu Lys Val Phe Ile 
            580                 585                 590         


Phe Gln Phe Val Asn Phe Tyr Ser Ser Pro Val Tyr Ile Ala Phe Phe 
        595                 600                 605             


Lys Gly Arg Phe Val Gly Tyr Pro Gly Asn Tyr His Thr Leu Phe Gly 
    610                 615                 620                 


Val Arg Asn Glu Glu Cys Ala Ala Gly Gly Cys Leu Ile Glu Leu Ala 
625                 630                 635                 640 


Gln Glu Leu Leu Val Ile Met Val Gly Lys Gln Val Ile Asn Asn Met 
                645                 650                 655     


Gln Glu Val Leu Ile Pro Lys Leu Lys Gly Trp Trp Gln Lys Phe Arg 
            660                 665                 670         


Leu Arg Ser Lys Lys Arg Lys Ala Gly Ala Ser Ala Gly Ala Ser Gln 
        675                 680                 685             


Gly Pro Trp Glu Asp Asp Tyr Glu Leu Val Pro Cys Glu Gly Leu Phe 
    690                 695                 700                 


Asp Glu Tyr Leu Glu Met Val Leu Gln Phe Gly Phe Val Thr Ile Phe 
705                 710                 715                 720 


Val Ala Ala Cys Pro Leu Ala Pro Leu Phe Ala Leu Leu Asn Asn Trp 
                725                 730                 735     


Val Glu Ile Arg Leu Asp Ala Arg Lys Phe Val Cys Glu Tyr Arg Arg 
            740                 745                 750         


Pro Val Ala Glu Arg Ala Gln Asp Ile Gly Ile Trp Phe His Ile Leu 
        755                 760                 765             


Ala Gly Leu Thr His Leu Ala Val Ile Ser Asn Ala Phe Leu Leu Ala 
    770                 775                 780                 


Phe Ser Ser Asp Phe Leu Pro Arg Ala Tyr Tyr Arg Trp Thr Arg Ala 
785                 790                 795                 800 


His Asp Leu Arg Gly Phe Leu Asn Phe Thr Leu Ala Arg Ala Pro Ser 
                805                 810                 815     


Ser Phe Ala Ala Ala His Asn Arg Thr Cys Arg Tyr Arg Ala Phe Arg 
            820                 825                 830         


Asp Asp Asp Gly His Tyr Ser Gln Thr Tyr Trp Asn Leu Leu Ala Ile 
        835                 840                 845             


Arg Leu Ala Phe Val Ile Val Phe Glu Val Ala Glu Ala Pro Ala Gly 
    850                 855                 860                 


Ser Pro Ile His Gly Met Arg Pro Arg Pro Cys Ala Leu Pro Asn Ser 
865                 870                 875                 880 


Ser Thr Trp 
            


<210>  863
<211>  179
<212>  PRT
<213>  Homo Sapiens

<400>  863

Met Arg Met Ala Ala Thr Ala Trp Ala Gly Leu Gln Gly Pro Pro Leu 
1               5                   10                  15      


Pro Thr Leu Cys Pro Ala Val Arg Thr Gly Leu Tyr Cys Arg Asp Gln 
            20                  25                  30          


Ala His Ala Glu Arg Trp Ala Met Thr Ser Glu Thr Ser Ser Gly Ser 
        35                  40                  45              


His Cys Ala Arg Ser Arg Met Leu Arg Arg Arg Ala Gln Glu Glu Asp 
    50                  55                  60                  


Ser Thr Val Leu Ile Asp Val Ser Pro Pro Glu Ala Glu Lys Arg Gly 
65                  70                  75                  80  


Ser Tyr Gly Ser Thr Ala His Ala Ser Glu Pro Gly Gly Gln Gln Ala 
                85                  90                  95      


Ala Ala Cys Arg Ala Gly Ser Pro Ala Lys Pro Arg Ile Asp Phe Val 
            100                 105                 110         


Leu Val Trp Glu Glu Asp Leu Lys Leu Asp Arg Gln Gln Asp Ser Ala 
        115                 120                 125             


Ala Arg Asp Arg Thr Asp Met His Arg Thr Trp Arg Glu Thr Phe Leu 
    130                 135                 140                 


Asp Asn Leu Arg Ala Ala Gly Leu Cys Val Asp Gln Val Arg Gly Gly 
145                 150                 155                 160 


Cys His Gly Gln Gly Pro Arg Pro Cys Ile His Ser Val Thr His Asp 
                165                 170                 175     


Leu Ala Ala 
            


<210>  864
<211>  186
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  864

Xaa Ala Gly Gly Ala Phe Arg Gly Leu Arg Ala Asp Gly Gly Gly Glu 
1               5                   10                  15      


Pro Gly Arg Asp Pro Leu Pro Ala Val Leu Gln Phe Gly Phe Val Thr 
            20                  25                  30          


Ile Phe Val Ala Ala Cys Pro Leu Ala Pro Leu Phe Ala Leu Leu Asn 
        35                  40                  45              


Asn Trp Val Glu Ile Arg Leu Asp Ala Arg Lys Phe Val Cys Glu Tyr 
    50                  55                  60                  


Arg Arg Pro Val Ala Glu Arg Ala Gln Asp Ile Gly Ile Trp Phe His 
65                  70                  75                  80  


Ile Leu Ala Gly Leu Thr His Leu Ala Val Ile Ser Asn Ala Phe Leu 
                85                  90                  95      


Leu Ala Phe Ser Ser Asp Phe Leu Pro Arg Ala Tyr Tyr Arg Trp Thr 
            100                 105                 110         


Arg Ala His Asp Leu Arg Gly Phe Leu Asn Phe Thr Leu Ala Arg Ala 
        115                 120                 125             


Pro Ser Ser Phe Ala Ala Ala His Asn Arg Thr Cys Arg Tyr Arg Ala 
    130                 135                 140                 


Phe Arg Asp Asp Asp Gly His Tyr Ser Gln Thr Tyr Trp Asn Leu Leu 
145                 150                 155                 160 


Ala Ile Arg Leu Ala Phe Val Ile Val Phe Glu His Val Val Phe Ser 
                165                 170                 175     


Val Gly Arg Leu Leu Asp Leu Leu Val Pro 
            180                 185     


<210>  865
<211>  680
<212>  PRT
<213>  Homo Sapiens

<400>  865

Met Val Pro Gly Val Pro Gly Ala Val Leu Thr Leu Cys Leu Trp Leu 
1               5                   10                  15      


Ala Ala Ser Ser Gly Cys Leu Ala Ala Gly Pro Gly Ala Ala Ala Ala 
            20                  25                  30          


Arg Arg Leu Asp Glu Ser Leu Ser Ala Gly Ser Val Gln Arg Ala Arg 
        35                  40                  45              


Cys Ala Ser Arg Cys Leu Ser Leu Gln Ile Thr Arg Ile Ser Ala Phe 
    50                  55                  60                  


Phe Gln His Phe Gln Asn Asn Gly Ser Leu Val Trp Cys Gln Asn His 
65                  70                  75                  80  


Lys Gln Cys Ser Lys Cys Leu Glu Pro Cys Lys Glu Ser Gly Asp Leu 
                85                  90                  95      


Arg Lys His Gln Cys Gln Ser Phe Cys Glu Pro Leu Phe Pro Lys Lys 
            100                 105                 110         


Ser Tyr Glu Cys Leu Thr Ser Cys Glu Phe Leu Lys Tyr Ile Leu Leu 
        115                 120                 125             


Val Lys Gln Gly Asp Cys Pro Ala Pro Glu Lys Ala Ser Gly Phe Ala 
    130                 135                 140                 


Ala Ala Cys Val Glu Ser Cys Glu Val Asp Asn Glu Cys Ser Gly Val 
145                 150                 155                 160 


Lys Lys Cys Cys Ser Asn Gly Cys Gly His Thr Cys Gln Val Pro Lys 
                165                 170                 175     


Thr Leu Tyr Lys Gly Val Pro Leu Lys Pro Arg Lys Glu Leu Arg Phe 
            180                 185                 190         


Thr Glu Leu Gln Ser Gly Gln Leu Glu Val Lys Trp Ser Ser Lys Phe 
        195                 200                 205             


Asn Ile Ser Ile Glu Pro Val Ile Tyr Val Val Gln Arg Arg Trp Asn 
    210                 215                 220                 


Tyr Gly Ile His Pro Ser Glu Asp Asp Ala Thr His Trp Gln Thr Val 
225                 230                 235                 240 


Ala Gln Thr Thr Asp Glu Arg Val Gln Leu Thr Asp Ile Arg Pro Ser 
                245                 250                 255     


Arg Trp Tyr Gln Phe Arg Val Ala Ala Val Asn Val His Gly Thr Arg 
            260                 265                 270         


Gly Phe Thr Ala Pro Ser Lys His Phe Arg Ser Ser Lys Asp Pro Ser 
        275                 280                 285             


Ala Pro Pro Ala Pro Ala Asn Leu Arg Leu Ala Asn Ser Thr Val Asn 
    290                 295                 300                 


Ser Asp Gly Ser Val Thr Val Thr Ile Val Trp Asp Leu Pro Glu Glu 
305                 310                 315                 320 


Pro Asp Ile Pro Val His His Tyr Lys Val Phe Trp Ser Trp Met Val 
                325                 330                 335     


Ser Ser Lys Ser Leu Val Pro Thr Lys Lys Lys Arg Arg Lys Thr Thr 
            340                 345                 350         


Asp Gly Phe Gln Asn Ser Val Ile Leu Glu Lys Leu Gln Pro Asp Cys 
        355                 360                 365             


Asp Tyr Val Val Glu Leu Gln Ala Ile Thr Tyr Trp Gly Gln Thr Arg 
    370                 375                 380                 


Leu Lys Ser Ala Lys Val Ser Leu His Phe Thr Ser Thr His Ala Thr 
385                 390                 395                 400 


Asn Asn Lys Glu Gln Leu Val Lys Thr Arg Lys Gly Gly Ile Gln Thr 
                405                 410                 415     


Gln Leu Pro Phe Gln Arg Arg Arg Pro Thr Arg Pro Leu Glu Val Gly 
            420                 425                 430         


Ala Pro Phe Tyr Gln Asp Gly Gln Leu Gln Val Lys Val Tyr Trp Lys 
        435                 440                 445             


Lys Thr Glu Asp Pro Thr Val Asn Arg Tyr His Val Arg Trp Phe Pro 
    450                 455                 460                 


Glu Ala Cys Ala His Asn Arg Thr Thr Gly Ser Glu Ala Ser Ser Gly 
465                 470                 475                 480 


Met Thr His Glu Asn Tyr Ile Ile Leu Gln Asp Leu Ser Phe Ser Cys 
                485                 490                 495     


Lys Tyr Lys Val Thr Val Gln Pro Ile Arg Pro Lys Ser His Ser Lys 
            500                 505                 510         


Ala Glu Ala Val Phe Phe Thr Thr Pro Pro Cys Ser Ala Leu Lys Gly 
        515                 520                 525             


Lys Ser His Lys Pro Val Gly Cys Leu Gly Glu Ala Gly His Val Leu 
    530                 535                 540                 


Ser Lys Val Leu Ala Lys Pro Glu Asn Leu Ser Ala Ser Phe Ile Val 
545                 550                 555                 560 


Gln Asp Val Asn Ile Thr Gly His Phe Ser Trp Lys Met Ala Lys Ala 
                565                 570                 575     


Asn Leu Tyr Gln Pro Met Thr Gly Phe Gln Val Thr Trp Ala Glu Val 
            580                 585                 590         


Thr Thr Glu Ser Arg Gln Asn Ser Leu Pro Asn Ser Ile Ile Ser Gln 
        595                 600                 605             


Ser Gln Ile Leu Pro Ser Asp His Tyr Val Leu Thr Val Pro Asn Leu 
    610                 615                 620                 


Arg Pro Ser Thr Leu Tyr Arg Leu Glu Val Gln Val Leu Thr Pro Gly 
625                 630                 635                 640 


Gly Glu Gly Pro Ala Thr Ile Lys Thr Phe Arg Thr Pro Glu Leu Pro 
                645                 650                 655     


Pro Ser Ser Ala His Arg Ser His Leu Lys His Arg His Pro His His 
            660                 665                 670         


Tyr Lys Pro Ser Pro Glu Arg Tyr 
        675                 680 


<210>  866
<211>  564
<212>  PRT
<213>  Homo Sapiens

<400>  866

Met Ala Thr Ala Glu Arg Arg Ala Leu Gly Ile Gly Phe Gln Trp Leu 
1               5                   10                  15      


Ser Leu Ala Thr Leu Val Leu Ile Cys Ala Gly Gln Gly Gly Arg Arg 
            20                  25                  30          


Glu Asp Gly Gly Pro Ala Cys Tyr Gly Gly Phe Asp Leu Tyr Phe Ile 
        35                  40                  45              


Leu Asp Lys Ser Gly Ser Val Leu His His Trp Asn Glu Ile Tyr Tyr 
    50                  55                  60                  


Phe Val Glu Gln Leu Ala His Lys Phe Ile Ser Pro Gln Leu Arg Met 
65                  70                  75                  80  


Ser Phe Ile Val Phe Ser Thr Arg Gly Thr Thr Leu Met Lys Leu Thr 
                85                  90                  95      


Glu Asp Arg Glu Gln Ile Arg Gln Gly Leu Glu Glu Leu Gln Lys Val 
            100                 105                 110         


Leu Pro Gly Gly Asp Thr Tyr Met His Glu Gly Phe Glu Arg Ala Ser 
        115                 120                 125             


Glu Gln Ile Tyr Tyr Glu Asn Arg Gln Gly Tyr Arg Thr Ala Ser Val 
    130                 135                 140                 


Ile Ile Ala Leu Thr Asp Gly Glu Leu His Glu Asp Leu Phe Phe Tyr 
145                 150                 155                 160 


Ser Glu Arg Glu Ala Asn Arg Ser Arg Asp Leu Gly Ala Ile Val Tyr 
                165                 170                 175     


Cys Val Gly Val Lys Asp Phe Asn Glu Thr Gln Leu Ala Arg Ile Ala 
            180                 185                 190         


Asp Ser Lys Asp His Val Phe Pro Val Asn Asp Gly Phe Gln Ala Leu 
        195                 200                 205             


Gln Gly Ile Ile His Ser Ile Leu Lys Lys Ser Cys Ile Glu Ile Leu 
    210                 215                 220                 


Ala Ala Glu Pro Ser Thr Ile Cys Ala Gly Glu Ser Phe Gln Val Val 
225                 230                 235                 240 


Val Arg Gly Asn Gly Phe Arg His Ala Arg Asn Val Asp Arg Val Leu 
                245                 250                 255     


Cys Ser Phe Lys Ile Asn Asp Ser Val Thr Leu Asn Glu Lys Pro Phe 
            260                 265                 270         


Ser Val Glu Asp Thr Tyr Leu Leu Cys Pro Ala Pro Ile Leu Lys Glu 
        275                 280                 285             


Val Gly Met Lys Ala Ala Leu Gln Val Ser Met Asn Asp Gly Leu Ser 
    290                 295                 300                 


Phe Ile Ser Ser Ser Val Ile Ile Thr Thr Thr His Cys Ser Asp Gly 
305                 310                 315                 320 


Ser Ile Leu Ala Ile Ala Leu Leu Ile Leu Phe Leu Leu Leu Ala Leu 
                325                 330                 335     


Ala Leu Leu Trp Trp Phe Trp Pro Leu Cys Cys Thr Val Ile Ile Lys 
            340                 345                 350         


Glu Val Pro Pro Pro Pro Ala Glu Glu Ser Glu Glu Glu Asp Asp Asp 
        355                 360                 365             


Gly Leu Pro Lys Lys Lys Trp Pro Thr Val Asp Ala Ser Tyr Tyr Gly 
    370                 375                 380                 


Gly Arg Gly Val Gly Gly Ile Lys Arg Met Glu Val Arg Trp Gly Glu 
385                 390                 395                 400 


Lys Gly Ser Thr Glu Glu Gly Ala Lys Leu Glu Lys Ala Lys Asn Ala 
                405                 410                 415     


Arg Val Lys Met Pro Glu Gln Glu Tyr Glu Phe Pro Glu Pro Arg Asn 
            420                 425                 430         


Leu Asn Asn Asn Met Arg Arg Pro Ser Ser Pro Arg Lys Trp Tyr Ser 
        435                 440                 445             


Pro Ile Lys Gly Lys Leu Asp Ala Leu Trp Val Leu Leu Arg Lys Gly 
    450                 455                 460                 


Tyr Asp Arg Val Ser Val Met Arg Pro Gln Pro Gly Asp Thr Gly Arg 
465                 470                 475                 480 


Cys Ile Asn Phe Thr Arg Val Lys Asn Asn Gln Pro Ala Lys Tyr Pro 
                485                 490                 495     


Leu Asn Asn Ala Tyr His Thr Ser Ser Pro Pro Pro Ala Pro Ile Tyr 
            500                 505                 510         


Thr Pro Pro Pro Pro Ala Pro His Cys Pro Pro Pro Pro Pro Ser Ala 
        515                 520                 525             


Pro Thr Pro Pro Ile Pro Ser Pro Pro Ser Thr Leu Pro Pro Pro Pro 
    530                 535                 540                 


Gln Ala Pro Pro Pro Asn Arg Ala Pro Pro Pro Ser Arg Pro Pro Pro 
545                 550                 555                 560 


Arg Pro Ser Val 
                


<210>  867
<211>  333
<212>  PRT
<213>  Homo Sapiens

<400>  867

Met Ala Thr Ala Glu Arg Arg Ala Leu Gly Ile Gly Phe Gln Trp Leu 
1               5                   10                  15      


Ser Leu Ala Thr Leu Val Leu Ile Cys Ala Gly Gln Gly Gly Arg Arg 
            20                  25                  30          


Glu Asp Gly Gly Pro Ala Cys Tyr Gly Gly Phe Asp Leu Tyr Phe Ile 
        35                  40                  45              


Leu Asp Lys Ser Gly Ser Val Leu His His Trp Asn Glu Ile Tyr Tyr 
    50                  55                  60                  


Phe Val Glu Gln Leu Ala His Lys Phe Ile Ser Pro Gln Leu Arg Met 
65                  70                  75                  80  


Ser Phe Ile Val Phe Ser Thr Arg Gly Thr Thr Leu Met Lys Leu Thr 
                85                  90                  95      


Glu Asp Arg Glu Gln Ile Arg Gln Gly Leu Glu Glu Leu Gln Lys Val 
            100                 105                 110         


Leu Pro Gly Gly Asp Thr Tyr Met His Glu Gly Phe Glu Arg Ala Ser 
        115                 120                 125             


Glu Gln Ile Tyr Tyr Glu Asn Arg Gln Gly Tyr Arg Thr Ala Ser Val 
    130                 135                 140                 


Ile Ile Ala Leu Thr Asp Gly Glu Leu His Glu Asp Leu Phe Phe Tyr 
145                 150                 155                 160 


Ser Glu Arg Glu Ala Asn Arg Ser Arg Asp Leu Gly Ala Ile Val Tyr 
                165                 170                 175     


Cys Val Gly Val Lys Asp Phe Asn Glu Thr Gln Leu Ala Arg Ile Ala 
            180                 185                 190         


Asp Ser Lys Asp His Val Phe Pro Val Asn Asp Gly Phe Gln Ala Leu 
        195                 200                 205             


Gln Gly Ile Ile His Ser Ile Leu Lys Lys Ser Cys Ile Glu Ile Leu 
    210                 215                 220                 


Ala Ala Glu Pro Ser Thr Ile Cys Ala Gly Glu Ser Phe Gln Val Val 
225                 230                 235                 240 


Val Arg Gly Asn Gly Phe Arg His Ala Arg Asn Val Asp Arg Val Leu 
                245                 250                 255     


Cys Ser Phe Lys Ile Asn Asp Ser Val Thr Leu Asn Glu Lys Pro Phe 
            260                 265                 270         


Ser Val Glu Asp Thr Tyr Leu Leu Cys Pro Ala Pro Ile Leu Lys Glu 
        275                 280                 285             


Val Gly Met Lys Ala Ala Leu Gln Val Ser Met Asn Asp Gly Leu Ser 
    290                 295                 300                 


Phe Ile Ser Ser Ser Val Ile Ile Thr Thr Thr His Cys Ser Leu His 
305                 310                 315                 320 


Lys Ile Ala Ser Gly Pro Thr Thr Ala Ala Cys Met Glu 
                325                 330             


<210>  868
<211>  368
<212>  PRT
<213>  Homo Sapiens

<400>  868

Met Ala Thr Ala Glu Arg Arg Ala Leu Gly Ile Gly Phe Gln Trp Leu 
1               5                   10                  15      


Ser Leu Ala Thr Leu Val Leu Ile Cys Ala Gly Gln Gly Gly Arg Arg 
            20                  25                  30          


Glu Asp Gly Gly Pro Ala Cys Tyr Gly Gly Phe Asp Leu Tyr Phe Ile 
        35                  40                  45              


Leu Asp Lys Ser Gly Ser Val Leu His His Trp Asn Glu Ile Tyr Tyr 
    50                  55                  60                  


Phe Val Glu Gln Leu Ala His Lys Phe Ile Ser Pro Gln Leu Arg Met 
65                  70                  75                  80  


Ser Phe Ile Val Phe Ser Thr Arg Gly Thr Thr Leu Met Lys Leu Thr 
                85                  90                  95      


Glu Asp Arg Glu Gln Ile Arg Gln Gly Leu Glu Glu Leu Gln Lys Val 
            100                 105                 110         


Leu Pro Gly Gly Asp Thr Tyr Met His Glu Gly Phe Glu Arg Ala Ser 
        115                 120                 125             


Glu Gln Ile Tyr Tyr Glu Asn Arg Gln Gly Tyr Arg Thr Ala Ser Val 
    130                 135                 140                 


Ile Ile Ala Leu Thr Asp Gly Glu Leu His Glu Asp Leu Phe Phe Tyr 
145                 150                 155                 160 


Ser Glu Arg Glu Ala Asn Arg Ser Arg Asp Leu Gly Ala Ile Val Tyr 
                165                 170                 175     


Cys Val Gly Val Lys Asp Phe Asn Glu Thr Gln Leu Ala Arg Ile Ala 
            180                 185                 190         


Asp Ser Lys Asp His Val Phe Pro Val Asn Asp Gly Phe Gln Ala Leu 
        195                 200                 205             


Gln Gly Ile Ile His Ser Ile Leu Lys Lys Ser Cys Ile Glu Ile Leu 
    210                 215                 220                 


Ala Ala Glu Pro Ser Thr Ile Cys Ala Gly Glu Ser Phe Gln Val Val 
225                 230                 235                 240 


Val Arg Gly Asn Gly Phe Arg His Ala Arg Asn Val Asp Arg Val Leu 
                245                 250                 255     


Cys Ser Phe Lys Ile Asn Asp Ser Val Thr Leu Asn Glu Lys Pro Phe 
            260                 265                 270         


Ser Val Glu Asp Thr Tyr Leu Leu Cys Pro Ala Pro Ile Leu Lys Glu 
        275                 280                 285             


Val Gly Met Lys Ala Ala Leu Gln Val Ser Met Asn Asp Gly Leu Ser 
    290                 295                 300                 


Phe Ile Ser Ser Ser Val Ile Ile Thr Thr Thr His Cys Ser Asp Gly 
305                 310                 315                 320 


Ser Ile Leu Ala Ile Ala Leu Leu Ile Leu Phe Leu Leu Leu Ala Leu 
                325                 330                 335     


Ala Leu Leu Trp Trp Phe Trp Pro Leu Cys Cys Thr Val Ile Ile Lys 
            340                 345                 350         


Glu Val Pro Pro Pro Pro Ala Glu Glu Ser Glu Glu Asn Lys Ile Lys 
        355                 360                 365             


<210>  869
<211>  179
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  869

Xaa Asp Leu Gly Ala Ile Val Tyr Cys Val Gly Val Lys Asp Phe Asn 
1               5                   10                  15      


Glu Thr Gln Leu Ala Arg Ile Ala Asp Ser Lys Asp His Val Phe Pro 
            20                  25                  30          


Val Asn Asp Gly Phe Gln Ala Leu Gln Gly Ile Ile His Ser Ile Leu 
        35                  40                  45              


Lys Lys Ser Cys Ile Glu Ile Leu Ala Ala Glu Pro Ser Thr Ile Cys 
    50                  55                  60                  


Ala Gly Glu Ser Phe Gln Val Val Val Arg Gly Asn Gly Phe Arg His 
65                  70                  75                  80  


Ala Arg Asn Val Asp Arg Val Leu Cys Ser Phe Lys Ile Asn Asp Ser 
                85                  90                  95      


Val Thr Leu Asn Glu Lys Pro Phe Ser Val Glu Asp Thr Tyr Leu Leu 
            100                 105                 110         


Cys Pro Ala Pro Ile Leu Lys Glu Val Gly Met Lys Ala Ala Leu Gln 
        115                 120                 125             


Val Ser Met Asn Asp Gly Leu Ser Phe Ile Ser Ser Ser Val Ile Ile 
    130                 135                 140                 


Thr Thr Thr His Cys Asp Gly Leu Trp Phe Tyr Ile Gln Ser Leu Glu 
145                 150                 155                 160 


Thr Val Lys Asp His Arg Asn Ile Arg Val Arg Asn Ser Asp Leu Lys 
                165                 170                 175     


Tyr Cys Leu 
            


<210>  870
<211>  52
<212>  PRT
<213>  Homo Sapiens

<400>  870

Met Gln Ser Pro Trp Lys Ile Leu Thr Val Ala Pro Leu Phe Leu Leu 
1               5                   10                  15      


Leu Ser Leu Gln Ser Ser Ala Ser Pro Ala Asn Asp Asp Gln Ser Arg 
            20                  25                  30          


Pro Ser Leu Ser Asn Gly His Thr Cys Val Ala Ser Ser Ala Glu Lys 
        35                  40                  45              


Pro Gln Leu Ser 
    50          


<210>  871
<211>  108
<212>  PRT
<213>  Homo Sapiens

<400>  871

Met Gln Ser Pro Trp Lys Ile Leu Thr Val Ala Pro Leu Phe Leu Leu 
1               5                   10                  15      


Leu Ser Leu Gln Ser Ser Ala Ser Pro Ala Asn Asp Asp Gln Ser Arg 
            20                  25                  30          


Pro Ser Leu Ser Asn Gly His Thr Cys Val Glu Lys Leu Phe Leu Lys 
        35                  40                  45              


Thr Thr Cys Tyr Leu Val Ile Asp Lys Phe Gly Ser Asp Ile Ile Lys 
    50                  55                  60                  


Leu Leu Ser Ala Asp Met Asn Ala Asp Val Val Cys His Thr Leu Glu 
65                  70                  75                  80  


Phe Cys Lys Gln Asn Thr Gly Gln Pro Leu Cys His Leu Tyr Pro Leu 
                85                  90                  95      


Pro Lys Glu Thr Trp Lys Phe Thr Leu Gln Lys Ala 
            100                 105             


<210>  872
<211>  543
<212>  PRT
<213>  Homo Sapiens

<400>  872

Met Gln Ser Pro Trp Lys Ile Leu Thr Val Ala Pro Leu Phe Leu Leu 
1               5                   10                  15      


Leu Ser Leu Gln Ser Ser Ala Ser Pro Ala Asn Asp Asp Gln Ser Arg 
            20                  25                  30          


Pro Ser Leu Ser Asn Gly His Thr Cys Val Glu Lys Leu Phe Leu Lys 
        35                  40                  45              


Thr Thr Cys Tyr Leu Val Ile Asp Lys Phe Gly Ser Asp Ile Ile Lys 
    50                  55                  60                  


Leu Leu Ser Ala Asp Met Asn Ala Asp Val Val Cys His Thr Leu Glu 
65                  70                  75                  80  


Phe Cys Lys Gln Asn Thr Gly Gln Pro Leu Cys His Leu Tyr Pro Leu 
                85                  90                  95      


Pro Lys Glu Thr Trp Lys Phe Thr Leu Gln Lys Ala Arg Gln Ile Val 
            100                 105                 110         


Lys Lys Ser Pro Ile Leu Lys Tyr Ser Arg Ser Gly Ser Asp Ile Cys 
        115                 120                 125             


Ser Leu Pro Val Leu Ala Lys Ile Cys Gln Lys Ile Lys Leu Ala Met 
    130                 135                 140                 


Glu Gln Ser Val Pro Phe Lys Asp Val Asp Ser Asp Lys Tyr Ser Val 
145                 150                 155                 160 


Phe Pro Thr Leu Arg Gly Tyr His Trp Arg Gly Arg Asp Cys Asn Asp 
                165                 170                 175     


Ser Asp Glu Ser Val Tyr Pro Gly Arg Arg Pro Asn Asn Trp Asp Val 
            180                 185                 190         


His Gln Asp Ser Asn Cys Asn Gly Ile Trp Gly Val Asp Pro Lys Asp 
        195                 200                 205             


Gly Val Pro Tyr Glu Lys Lys Phe Cys Glu Gly Ser Gln Pro Arg Gly 
    210                 215                 220                 


Ile Ile Leu Leu Gly Asp Ser Ala Gly Ala His Phe His Ile Ser Pro 
225                 230                 235                 240 


Glu Trp Ile Thr Ala Ser Gln Met Ser Leu Asn Ser Phe Ile Asn Leu 
                245                 250                 255     


Pro Thr Ala Leu Thr Asn Glu Leu Asp Trp Pro Gln Leu Ser Gly Ala 
            260                 265                 270         


Thr Gly Phe Leu Asp Ser Thr Val Gly Ile Lys Glu Lys Ser Ile Tyr 
        275                 280                 285             


Leu Arg Leu Trp Lys Arg Asn His Cys Asn His Arg Asp Tyr Gln Asn 
    290                 295                 300                 


Ile Ser Arg Asn Gly Ala Ser Ser Arg Asn Leu Lys Lys Phe Ile Glu 
305                 310                 315                 320 


Ser Leu Ser Arg Asn Lys Val Leu Asp Tyr Pro Ala Ile Val Ile Tyr 
                325                 330                 335     


Ala Met Ile Gly Asn Asp Val Cys Ser Gly Lys Ser Asp Pro Val Pro 
            340                 345                 350         


Ala Met Thr Thr Pro Glu Lys Leu Tyr Ser Asn Val Met Gln Thr Leu 
        355                 360                 365             


Lys His Leu Asn Ser His Leu Pro Asn Gly Ser His Val Ile Leu Tyr 
    370                 375                 380                 


Gly Leu Pro Asp Gly Thr Phe Leu Trp Asp Asn Leu His Asn Arg Tyr 
385                 390                 395                 400 


His Pro Leu Gly Gln Leu Asn Lys Asp Met Thr Tyr Ala Gln Leu Tyr 
                405                 410                 415     


Ser Phe Leu Asn Cys Leu Gln Val Ser Pro Cys His Gly Trp Met Ser 
            420                 425                 430         


Ser Asn Lys Thr Leu Arg Thr Leu Thr Ser Glu Arg Ala Glu Gln Leu 
        435                 440                 445             


Ser Asn Thr Leu Lys Lys Ile Ala Ala Ser Glu Lys Phe Thr Asn Phe 
    450                 455                 460                 


Asn Leu Phe Tyr Met Asp Phe Ala Phe His Glu Ile Ile Gln Glu Trp 
465                 470                 475                 480 


Gln Lys Arg Gly Gly Gln Pro Trp Gln Leu Ile Glu Pro Val Asp Gly 
                485                 490                 495     


Phe His Pro Asn Glu Val Ala Leu Leu Leu Leu Ala Asp His Phe Trp 
            500                 505                 510         


Lys Lys Val Gln Leu Gln Trp Pro Gln Ile Leu Gly Lys Glu Asn Pro 
        515                 520                 525             


Phe Asn Pro Gln Ile Lys Gln Val Phe Gly Asp Gln Gly Gly His 
    530                 535                 540             


<210>  873
<211>  688
<212>  PRT
<213>  Homo Sapiens

<400>  873

Met Gln Ser Pro Trp Lys Ile Leu Thr Val Ala Pro Leu Phe Leu Leu 
1               5                   10                  15      


Leu Ser Leu Gln Ser Ser Ala Ser Pro Ala Asn Asp Asp Gln Ser Arg 
            20                  25                  30          


Pro Ser Leu Ser Asn Gly His Thr Cys Val Gly Cys Val Leu Val Val 
        35                  40                  45              


Ser Val Ile Glu Gln Leu Ala Gln Val His Asn Ser Thr Val Gln Ala 
    50                  55                  60                  


Ser Met Glu Arg Leu Cys Ser Tyr Leu Pro Glu Lys Leu Phe Leu Lys 
65                  70                  75                  80  


Thr Thr Cys Tyr Leu Val Ile Asp Lys Phe Gly Ser Asp Ile Ile Lys 
                85                  90                  95      


Leu Leu Ser Ala Asp Met Asn Ala Asp Val Val Cys His Thr Leu Glu 
            100                 105                 110         


Phe Cys Lys Gln Asn Thr Gly Gln Pro Leu Cys His Leu Tyr Pro Leu 
        115                 120                 125             


Pro Lys Glu Thr Trp Lys Phe Thr Leu Gln Lys Ala Arg Gln Ile Val 
    130                 135                 140                 


Lys Lys Ser Pro Ile Leu Lys Tyr Ser Arg Ser Gly Ser Asp Ile Cys 
145                 150                 155                 160 


Ser Leu Pro Val Leu Ala Lys Ile Cys Gln Lys Ile Lys Leu Ala Met 
                165                 170                 175     


Glu Gln Ser Val Pro Phe Lys Asp Val Asp Ser Asp Lys Tyr Ser Val 
            180                 185                 190         


Phe Pro Thr Leu Arg Gly Tyr His Trp Arg Gly Arg Asp Cys Asn Asp 
        195                 200                 205             


Ser Asp Glu Ser Val Tyr Pro Gly Arg Arg Pro Asn Asn Trp Asp Val 
    210                 215                 220                 


His Gln Asp Ser Asn Cys Asn Gly Ile Trp Gly Val Asp Pro Lys Asp 
225                 230                 235                 240 


Gly Val Pro Tyr Glu Lys Lys Phe Cys Glu Gly Ser Gln Pro Arg Gly 
                245                 250                 255     


Ile Ile Leu Leu Gly Asp Ser Ala Gly Ala His Phe His Ile Ser Pro 
            260                 265                 270         


Glu Trp Ile Thr Ala Ser Gln Met Ser Leu Asn Ser Phe Ile Asn Leu 
        275                 280                 285             


Pro Thr Ala Leu Thr Asn Glu Leu Asp Trp Pro Gln Leu Ser Gly Ala 
    290                 295                 300                 


Thr Gly Phe Leu Asp Ser Thr Val Gly Ile Lys Glu Lys Ser Ile Tyr 
305                 310                 315                 320 


Leu Arg Leu Trp Lys Arg Asn His Cys Asn His Arg Asp Tyr Gln Asn 
                325                 330                 335     


Ile Ser Arg Asn Gly Ala Ser Ser Arg Asn Leu Lys Lys Phe Ile Glu 
            340                 345                 350         


Ser Leu Ser Arg Asn Lys Val Leu Asp Tyr Pro Ala Ile Val Ile Tyr 
        355                 360                 365             


Ala Met Ile Gly Asn Asp Val Cys Ser Gly Lys Ser Asp Pro Val Pro 
    370                 375                 380                 


Ala Met Thr Thr Pro Glu Lys Leu Tyr Ser Asn Val Met Gln Thr Leu 
385                 390                 395                 400 


Lys His Leu Asn Ser His Leu Pro Asn Gly Ser His Val Ile Leu Tyr 
                405                 410                 415     


Gly Leu Pro Asp Gly Thr Phe Leu Trp Asp Asn Leu His Asn Arg Tyr 
            420                 425                 430         


His Pro Leu Gly Gln Leu Asn Lys Asp Met Thr Tyr Ala Gln Leu Tyr 
        435                 440                 445             


Ser Phe Leu Asn Cys Leu Gln Val Ser Pro Cys His Gly Trp Met Ser 
    450                 455                 460                 


Ser Asn Lys Thr Leu Arg Thr Leu Thr Ser Glu Arg Ala Glu Gln Leu 
465                 470                 475                 480 


Ser Asn Thr Leu Lys Lys Ile Ala Ala Ser Glu Lys Phe Thr Asn Phe 
                485                 490                 495     


Asn Leu Phe Tyr Met Asp Phe Ala Phe His Glu Ile Ile Gln Glu Trp 
            500                 505                 510         


Gln Lys Arg Gly Gly Gln Pro Trp Gln Leu Ile Glu Pro Val Asp Gly 
        515                 520                 525             


Phe His Pro Asn Glu Arg Lys Ser Ile Leu Leu Lys Gly Ile Leu Met 
    530                 535                 540                 


Thr Ser Gln Thr Leu Asp Asn Gln Glu Trp Thr Gln Leu Thr Ser Trp 
545                 550                 555                 560 


Ile Lys Gly Asn Leu Thr Cys Asp Ser Arg Thr Arg Glu Trp Leu Cys 
                565                 570                 575     


Cys Cys Trp Arg Ile Ile Ser Gly Lys Arg Cys Ser Ser Ser Gly Pro 
            580                 585                 590         


Lys Ser Trp Glu Arg Arg Ile Arg Ser Thr Pro Arg Leu Asn Arg Cys 
        595                 600                 605             


Leu Glu Thr Lys Ala Gly Thr Glu Pro Leu Arg Ser Met His Pro Trp 
    610                 615                 620                 


Gly Ala Gln Gly Gly Arg Gly Leu Gly Lys Leu Ile Pro Gln Thr Leu 
625                 630                 635                 640 


Trp Gly Leu Pro Arg His Arg Pro Lys Gly Leu Phe Phe Ser Ser Ile 
                645                 650                 655     


Phe Ala Lys Cys Leu Ser Leu Asn Glu Glu His Ile Trp Thr Thr Val 
            660                 665                 670         


Gln Cys Cys Val Leu Pro Gly Ser Val Thr Leu Pro Leu Phe Leu Lys 
        675                 680                 685             


<210>  874
<211>  575
<212>  PRT
<213>  Homo Sapiens

<400>  874

Met Gln Ser Pro Trp Lys Ile Leu Thr Val Ala Pro Leu Phe Leu Leu 
1               5                   10                  15      


Leu Ser Leu Gln Ser Ser Ala Ser Pro Ala Asn Asp Asp Gln Ser Arg 
            20                  25                  30          


Pro Ser Leu Ser Asn Gly His Thr Cys Val Gly Cys Val Leu Val Val 
        35                  40                  45              


Ser Val Ile Glu Gln Leu Ala Gln Val His Asn Ser Thr Val Gln Ala 
    50                  55                  60                  


Ser Met Glu Arg Leu Cys Ser Tyr Leu Pro Glu Lys Leu Phe Leu Lys 
65                  70                  75                  80  


Thr Thr Cys Tyr Leu Val Ile Asp Lys Phe Gly Ser Asp Ile Ile Lys 
                85                  90                  95      


Leu Leu Ser Ala Asp Met Asn Ala Asp Val Val Cys His Thr Leu Glu 
            100                 105                 110         


Phe Cys Lys Gln Asn Thr Gly Gln Pro Leu Cys His Leu Tyr Pro Leu 
        115                 120                 125             


Pro Lys Glu Thr Trp Lys Phe Thr Leu Gln Lys Ala Arg Gln Ile Val 
    130                 135                 140                 


Lys Lys Ser Pro Ile Leu Lys Tyr Ser Arg Ser Gly Ser Asp Ile Cys 
145                 150                 155                 160 


Ser Leu Pro Val Leu Ala Lys Ile Cys Gln Lys Ile Lys Leu Ala Met 
                165                 170                 175     


Glu Gln Ser Val Pro Phe Lys Asp Val Asp Ser Asp Lys Tyr Ser Val 
            180                 185                 190         


Phe Pro Thr Leu Arg Gly Tyr His Trp Arg Gly Arg Asp Cys Asn Asp 
        195                 200                 205             


Ser Asp Glu Ser Val Tyr Pro Gly Arg Arg Pro Asn Asn Trp Asp Val 
    210                 215                 220                 


His Gln Asp Ser Asn Cys Asn Gly Ile Trp Gly Val Asp Pro Lys Asp 
225                 230                 235                 240 


Gly Val Pro Tyr Glu Lys Lys Phe Cys Glu Gly Ser Gln Pro Arg Gly 
                245                 250                 255     


Ile Ile Leu Leu Gly Asp Ser Ala Gly Ala His Phe His Ile Ser Pro 
            260                 265                 270         


Glu Trp Ile Thr Ala Ser Gln Met Ser Leu Asn Ser Phe Ile Asn Leu 
        275                 280                 285             


Pro Thr Ala Leu Thr Asn Glu Leu Asp Trp Pro Gln Leu Ser Gly Ala 
    290                 295                 300                 


Thr Gly Phe Leu Asp Ser Thr Val Gly Ile Lys Glu Lys Ser Ile Tyr 
305                 310                 315                 320 


Leu Arg Leu Trp Lys Arg Asn His Cys Asn His Arg Asp Tyr Gln Asn 
                325                 330                 335     


Ile Ser Arg Asn Gly Ala Ser Ser Arg Asn Leu Lys Lys Phe Ile Glu 
            340                 345                 350         


Ser Leu Ser Arg Asn Lys Val Leu Asp Tyr Pro Ala Ile Val Ile Tyr 
        355                 360                 365             


Ala Met Ile Gly Asn Asp Val Cys Ser Gly Lys Ser Asp Pro Val Pro 
    370                 375                 380                 


Ala Met Thr Thr Pro Glu Lys Leu Tyr Ser Asn Val Met Gln Thr Leu 
385                 390                 395                 400 


Lys His Leu Asn Ser His Leu Pro Asn Gly Ser His Val Ile Leu Tyr 
                405                 410                 415     


Gly Leu Pro Asp Gly Thr Phe Leu Trp Asp Asn Leu His Asn Arg Tyr 
            420                 425                 430         


His Pro Leu Gly Gln Leu Asn Lys Asp Met Thr Tyr Ala Gln Leu Tyr 
        435                 440                 445             


Ser Phe Leu Asn Cys Leu Gln Val Ser Pro Cys His Gly Trp Met Ser 
    450                 455                 460                 


Ser Asn Lys Thr Leu Arg Thr Leu Thr Ser Glu Arg Ala Glu Gln Leu 
465                 470                 475                 480 


Ser Asn Thr Leu Lys Lys Ile Ala Ala Ser Glu Lys Phe Thr Asn Phe 
                485                 490                 495     


Asn Leu Phe Tyr Met Asp Phe Ala Phe His Glu Ile Ile Gln Glu Trp 
            500                 505                 510         


Gln Lys Arg Gly Gly Gln Pro Trp Gln Leu Ile Glu Pro Val Asp Gly 
        515                 520                 525             


Phe His Pro Asn Glu Val Ala Leu Leu Leu Leu Ala Asp His Phe Trp 
    530                 535                 540                 


Lys Lys Val Gln Leu Gln Trp Pro Gln Ile Leu Gly Lys Glu Asn Pro 
545                 550                 555                 560 


Phe Asn Pro Gln Ile Lys Gln Val Phe Gly Asp Gln Gly Gly His 
                565                 570                 575 


<210>  875
<211>  249
<212>  PRT
<213>  Homo Sapiens

<400>  875

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Cys Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu 
                245                 


<210>  876
<211>  751
<212>  PRT
<213>  Homo Sapiens

<400>  876

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Cys Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Arg Phe Lys Arg Lys Leu Pro Lys Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Thr 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
    610                 615                 620                 


Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
625                 630                 635                 640 


Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                645                 650                 655     


Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
            660                 665                 670         


Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
        675                 680                 685             


Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
    690                 695                 700                 


Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
705                 710                 715                 720 


Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                725                 730                 735     


Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val 
            740                 745                 750     


<210>  877
<211>  770
<212>  PRT
<213>  Homo Sapiens

<400>  877

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Cys Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Arg Phe Lys Arg Lys Leu Pro Lys Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Thr 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Thr Glu Gly Gly Gln 
    610                 615                 620                 


Pro Arg Ala Leu Ser Gln Ala Ala Ser Pro Val Pro Gly Arg Tyr Pro 
625                 630                 635                 640 


Leu Ala Val Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile 
                645                 650                 655     


Tyr His Gln Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe 
            660                 665                 670         


Leu His Asn Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val 
        675                 680                 685             


Thr Val Gly Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr 
    690                 695                 700                 


Ala Thr Pro Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe 
705                 710                 715                 720 


Phe Pro Glu Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp 
                725                 730                 735     


Pro Arg Asp Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp 
            740                 745                 750         


Arg Asp Cys Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg 
        755                 760                 765             


Pro Val 
    770 


<210>  878
<211>  751
<212>  PRT
<213>  Homo Sapiens

<400>  878

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Cys Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Arg Phe Lys Arg Lys Leu Pro Lys Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Thr 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
    610                 615                 620                 


Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
625                 630                 635                 640 


Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                645                 650                 655     


Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
            660                 665                 670         


Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
        675                 680                 685             


Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
    690                 695                 700                 


Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
705                 710                 715                 720 


Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                725                 730                 735     


Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val 
            740                 745                 750     


<210>  879
<211>  337
<212>  PRT
<213>  Homo Sapiens

<400>  879

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Cys Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu 
    


<210>  880
<211>  751
<212>  PRT
<213>  Homo Sapiens

<400>  880

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Cys Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Arg Phe Lys Arg Lys Leu Pro Lys Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Thr 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Tyr Pro Leu Ala Val 
    610                 615                 620                 


Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile Tyr His Gln 
625                 630                 635                 640 


Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe Leu His Asn 
                645                 650                 655     


Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val Thr Val Gly 
            660                 665                 670         


Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr Ala Thr Pro 
        675                 680                 685             


Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe Phe Pro Glu 
    690                 695                 700                 


Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp Pro Arg Asp 
705                 710                 715                 720 


Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp Arg Asp Cys 
                725                 730                 735     


Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg Pro Val 
            740                 745                 750     


<210>  881
<211>  756
<212>  PRT
<213>  Homo Sapiens

<400>  881

Met His Leu Lys Ile Val Leu Ala Phe Leu Ala Leu Ser Leu Ile Thr 
1               5                   10                  15      


Ile Phe Ala Leu Ala Tyr Val Leu Leu Thr Ser Pro Gly Gly Ser Ser 
            20                  25                  30          


Gln Pro Pro His Cys Pro Ser Val Ser His Arg Ala Gln Pro Trp Pro 
        35                  40                  45              


His Pro Gly Gln Ser Gln Leu Phe Ala Asp Leu Ser Arg Glu Glu Leu 
    50                  55                  60                  


Thr Ala Val Met Arg Phe Leu Thr Gln Arg Leu Gly Pro Gly Leu Val 
65                  70                  75                  80  


Asp Ala Ala Gln Ala Gln Pro Ser Asp Asn Cys Ile Phe Ser Val Glu 
                85                  90                  95      


Leu Gln Leu Pro Pro Lys Ala Ala Ala Leu Ala His Leu Asp Arg Gly 
            100                 105                 110         


Ser Pro Pro Pro Ala Arg Glu Ala Leu Ala Ile Val Leu Phe Gly Gly 
        115                 120                 125             


Gln Pro Gln Pro Asn Val Ser Glu Leu Val Val Gly Pro Leu Pro His 
    130                 135                 140                 


Pro Ser Tyr Met Arg Asp Val Thr Val Glu Arg His Gly Gly Pro Leu 
145                 150                 155                 160 


Pro Tyr His Arg Arg Pro Val Leu Arg Ala Glu Phe Thr Gln Met Trp 
                165                 170                 175     


Arg His Leu Lys Glu Val Glu Leu Pro Lys Ala Pro Ile Phe Leu Ser 
            180                 185                 190         


Ser Thr Phe Asn Tyr Asn Gly Ser Thr Leu Ala Ala Val His Ala Thr 
        195                 200                 205             


Pro Arg Gly Leu Arg Ser Gly Asp Arg Ala Thr Trp Met Ala Leu Tyr 
    210                 215                 220                 


His Asn Ile Ser Gly Val Gly Leu Phe Leu His Pro Val Gly Leu Glu 
225                 230                 235                 240 


Leu Leu Leu Asp His Arg Ala Leu Asp Pro Ala His Trp Thr Val Gln 
                245                 250                 255     


Gln Val Phe Tyr Leu Gly His Tyr Tyr Ala Asp Leu Gly Gln Leu Glu 
            260                 265                 270         


Arg Glu Phe Lys Ser Gly Arg Leu Glu Val Val Arg Val Pro Leu Pro 
        275                 280                 285             


Pro Pro Asn Gly Ala Ser Ser Leu Arg Ser Arg Asn Ser Pro Gly Pro 
    290                 295                 300                 


Leu Pro Pro Leu Gln Phe Ser Pro Gln Gly Ser Gln Tyr Ser Val Gln 
305                 310                 315                 320 


Gly Asn Leu Val Val Ser Ser Leu Trp Ser Phe Thr Phe Gly His Gly 
                325                 330                 335     


Val Phe Ser Gly Leu Arg Ile Phe Asp Val Arg Phe Gln Gly Glu Arg 
            340                 345                 350         


Ile Ala Tyr Glu Val Ser Val Gln Glu Cys Val Ser Ile Tyr Gly Ala 
        355                 360                 365             


Asp Ser Pro Lys Thr Met Leu Thr Arg Tyr Leu Asp Ser Ser Phe Gly 
    370                 375                 380                 


Leu Gly Arg Asn Ser Arg Gly Leu Val Arg Gly Val Asp Cys Pro Tyr 
385                 390                 395                 400 


Gln Ala Thr Met Val Asp Ile His Ile Leu Val Gly Lys Gly Ala Val 
                405                 410                 415     


Gln Leu Leu Pro Gly Ala Val Cys Val Phe Glu Glu Ala Gln Gly Leu 
            420                 425                 430         


Pro Leu Arg Arg His His Asn Tyr Leu Gln Asn His Phe Tyr Gly Gly 
        435                 440                 445             


Leu Ala Ser Ser Ala Leu Val Val Arg Ser Val Ser Ser Val Gly Asn 
    450                 455                 460                 


Tyr Asp Tyr Ile Trp Asp Phe Val Leu Tyr Pro Asn Gly Ala Leu Glu 
465                 470                 475                 480 


Gly Arg Val His Ala Thr Gly Tyr Ile Asn Thr Ala Phe Leu Lys Gly 
                485                 490                 495     


Gly Glu Glu Gly Leu Leu Phe Gly Asn Arg Val Gly Glu Arg Val Leu 
            500                 505                 510         


Gly Thr Val His Thr His Ala Phe His Phe Lys Leu Asp Leu Asp Val 
        515                 520                 525             


Ala Gly Leu Lys Asn Trp Val Val Ala Glu Asp Val Val Phe Lys Pro 
    530                 535                 540                 


Val Ala Ala Pro Trp Asn Pro Glu His Trp Leu Gln Arg Pro Gln Leu 
545                 550                 555                 560 


Thr Arg Gln Val Leu Gly Lys Glu Asp Leu Thr Ala Phe Ser Leu Gly 
                565                 570                 575     


Ser Pro Leu Pro Arg Tyr Leu Tyr Leu Ala Ser Asn Gln Thr Asn Ala 
            580                 585                 590         


Trp Gly His Gln Arg Gly Tyr Arg Ile Gln Ile His Ser Pro Leu Gly 
        595                 600                 605             


Ile His Ile Pro Leu Glu Ser Asp Met Glu Arg Ala Leu Ser Trp Gly 
    610                 615                 620                 


Arg Tyr Gln Leu Val Val Thr Gln Arg Lys Glu Glu Glu Ser Gln Ser 
625                 630                 635                 640 


Ser Ser Ile Tyr His Gln Asn Asp Ile Trp Thr Pro Thr Val Thr Phe 
                645                 650                 655     


Ala Asp Phe Ile Asn Asn Glu Thr Leu Leu Gly Glu Asp Leu Val Ala 
            660                 665                 670         


Trp Val Thr Ala Ser Phe Leu His Ile Pro His Ala Glu Asp Ile Pro 
        675                 680                 685             


Asn Thr Val Thr Leu Gly Asn Arg Val Gly Phe Leu Leu Arg Pro Tyr 
    690                 695                 700                 


Asn Phe Phe Asp Glu Asp Pro Ser Ile Phe Ser Pro Gly Ser Val Tyr 
705                 710                 715                 720 


Phe Glu Lys Gly Gln Asp Ala Gly Leu Cys Ser Ile Asn Pro Val Ala 
                725                 730                 735     


Cys Leu Pro Asp Leu Ala Ala Cys Val Pro Asp Leu Pro Pro Phe Ser 
            740                 745                 750         


Tyr His Gly Phe 
        755     


<210>  882
<211>  729
<212>  PRT
<213>  Homo Sapiens

<400>  882

Met His Leu Lys Ile Val Leu Ala Phe Leu Ala Leu Ser Leu Ile Thr 
1               5                   10                  15      


Ile Phe Ala Leu Ala Tyr Val Leu Leu Thr Ser Pro Gly Gly Ser Ser 
            20                  25                  30          


Gln Pro Pro His Cys Pro Ser Val Ser His Arg Ala Gln Pro Trp Pro 
        35                  40                  45              


His Pro Gly Gln Ser Gln Leu Phe Ala Asp Leu Ser Arg Glu Glu Leu 
    50                  55                  60                  


Thr Ala Val Met Arg Phe Leu Thr Gln Arg Leu Gly Pro Gly Leu Val 
65                  70                  75                  80  


Asp Ala Ala Gln Ala Gln Pro Ser Asp Asn Cys Ile Phe Ser Val Glu 
                85                  90                  95      


Leu Gln Leu Pro Pro Lys Ala Ala Ala Leu Ala His Leu Asp Arg Gly 
            100                 105                 110         


Ser Pro Pro Pro Ala Arg Glu Ala Leu Ala Ile Val Leu Phe Gly Gly 
        115                 120                 125             


Gln Pro Gln Pro Asn Val Ser Glu Leu Val Val Gly Pro Leu Pro His 
    130                 135                 140                 


Pro Ser Tyr Met Arg Asp Val Thr Val Glu Arg His Gly Gly Pro Leu 
145                 150                 155                 160 


Pro Tyr His Arg Arg Pro Val Leu Arg Ala Glu Phe Thr Gln Met Trp 
                165                 170                 175     


Arg His Leu Lys Glu Val Glu Leu Pro Lys Ala Pro Ile Phe Leu Ser 
            180                 185                 190         


Ser Thr Phe Asn Tyr Asn Gly Ser Thr Leu Ala Ala Val His Ala Thr 
        195                 200                 205             


Pro Arg Gly Leu Arg Ser Gly Asp Arg Ala Thr Trp Met Ala Leu Tyr 
    210                 215                 220                 


His Asn Ile Ser Gly Val Gly Leu Phe Leu His Pro Val Gly Leu Glu 
225                 230                 235                 240 


Leu Leu Leu Asp His Arg Ala Leu Asp Pro Ala His Trp Thr Val Gln 
                245                 250                 255     


Gln Val Phe Tyr Leu Gly His Tyr Tyr Ala Asp Leu Gly Gln Leu Glu 
            260                 265                 270         


Arg Glu Phe Lys Ser Gly Arg Leu Glu Val Val Arg Val Pro Leu Pro 
        275                 280                 285             


Pro Pro Asn Gly Ala Ser Ser Leu Arg Ser Arg Asn Ser Pro Gly Pro 
    290                 295                 300                 


Leu Pro Pro Leu Gln Phe Ser Pro Gln Gly Ser Gln Tyr Ser Val Gln 
305                 310                 315                 320 


Gly Asn Leu Val Val Ser Ser Leu Trp Ser Phe Thr Phe Gly His Gly 
                325                 330                 335     


Val Phe Ser Gly Leu Arg Ile Phe Asp Val Arg Phe Gln Gly Glu Arg 
            340                 345                 350         


Ile Ala Tyr Glu Val Ser Val Gln Glu Cys Val Ser Ile Tyr Gly Ala 
        355                 360                 365             


Asp Ser Pro Lys Thr Met Leu Thr Arg Tyr Leu Asp Ser Ser Phe Gly 
    370                 375                 380                 


Leu Gly Arg Asn Ser Arg Gly Leu Val Arg Gly Val Asp Cys Pro Tyr 
385                 390                 395                 400 


Gln Ala Thr Met Val Asp Ile His Ile Leu Val Gly Lys Gly Ala Val 
                405                 410                 415     


Gln Leu Leu Pro Gly Ala Val Cys Val Phe Glu Glu Ala Gln Gly Leu 
            420                 425                 430         


Pro Leu Arg Arg His His Asn Tyr Leu Gln Asn His Phe Tyr Gly Gly 
        435                 440                 445             


Leu Ala Ser Ser Ala Leu Val Val Arg Ser Val Ser Ser Val Gly Asn 
    450                 455                 460                 


Tyr Asp Tyr Ile Trp Asp Phe Val Leu Tyr Pro Asn Gly Ala Leu Glu 
465                 470                 475                 480 


Gly Arg Val His Ala Thr Gly Tyr Ile Asn Thr Ala Phe Leu Lys Gly 
                485                 490                 495     


Gly Glu Glu Gly Leu Leu Phe Gly Asn Arg Val Gly Glu Arg Val Leu 
            500                 505                 510         


Gly Thr Val His Thr His Ala Phe His Phe Lys Leu Asp Leu Asp Val 
        515                 520                 525             


Ala Gly Leu Lys Asn Trp Val Val Ala Glu Asp Val Val Phe Lys Pro 
    530                 535                 540                 


Val Ala Ala Pro Trp Asn Pro Glu His Trp Leu Gln Arg Pro Gln Leu 
545                 550                 555                 560 


Thr Arg Gln Val Leu Gly Lys Glu Asp Leu Thr Ala Phe Ser Leu Gly 
                565                 570                 575     


Ser Pro Leu Pro Arg Tyr Leu Tyr Leu Ala Ser Asn Gln Thr Asn Ala 
            580                 585                 590         


Trp Gly His Gln Arg Gly Tyr Gln Leu Val Val Thr Gln Arg Lys Glu 
        595                 600                 605             


Glu Glu Ser Gln Ser Ser Ser Ile Tyr His Gln Asn Asp Ile Trp Thr 
    610                 615                 620                 


Pro Thr Val Thr Phe Ala Asp Phe Ile Asn Asn Glu Thr Leu Leu Gly 
625                 630                 635                 640 


Glu Asp Leu Val Ala Trp Val Thr Ala Ser Phe Leu His Ile Pro His 
                645                 650                 655     


Ala Glu Asp Ile Pro Asn Thr Val Thr Leu Gly Asn Arg Val Gly Phe 
            660                 665                 670         


Leu Leu Arg Pro Tyr Asn Phe Phe Asp Glu Asp Pro Ser Ile Phe Ser 
        675                 680                 685             


Pro Gly Ser Val Tyr Phe Glu Lys Gly Gln Asp Ala Gly Leu Cys Ser 
    690                 695                 700                 


Ile Asn Pro Val Ala Cys Leu Pro Asp Leu Ala Ala Cys Val Pro Asp 
705                 710                 715                 720 


Leu Pro Pro Phe Ser Tyr His Gly Phe 
                725                 


<210>  883
<211>  763
<212>  PRT
<213>  Homo Sapiens

<400>  883

Met Asn Gln Lys Thr Ile Leu Val Leu Leu Ile Leu Ala Val Ile Thr 
1               5                   10                  15      


Ile Phe Ala Leu Val Cys Val Leu Leu Val Gly Arg Gly Gly Asp Gly 
            20                  25                  30          


Gly Glu Pro Ser Gln Leu Pro His Cys Pro Ser Val Ser Pro Ser Ala 
        35                  40                  45              


Gln Pro Trp Thr His Pro Gly Gln Ser Gln Leu Phe Ala Asp Leu Ser 
    50                  55                  60                  


Arg Glu Glu Leu Thr Ala Val Met Arg Phe Leu Thr Gln Arg Leu Gly 
65                  70                  75                  80  


Pro Gly Leu Val Asp Ala Ala Gln Ala Arg Pro Ser Asp Asn Cys Val 
                85                  90                  95      


Phe Ser Val Glu Leu Gln Leu Pro Pro Lys Ala Ala Ala Leu Ala His 
            100                 105                 110         


Leu Asp Arg Gly Ser Pro Pro Pro Ala Arg Glu Ala Leu Ala Ile Val 
        115                 120                 125             


Phe Phe Gly Arg Gln Pro Gln Pro Asn Val Ser Glu Leu Val Val Gly 
    130                 135                 140                 


Pro Leu Pro His Pro Ser Tyr Met Arg Asp Val Thr Val Glu Arg His 
145                 150                 155                 160 


Gly Gly Pro Leu Pro Tyr His Arg Arg Pro Val Leu Phe Gln Glu Tyr 
                165                 170                 175     


Leu Asp Ile Asp Gln Met Ile Phe Asn Arg Glu Leu Pro Gln Ala Ser 
            180                 185                 190         


Gly Leu Leu His His Cys Cys Phe Tyr Lys His Arg Gly Arg Asn Leu 
        195                 200                 205             


Val Thr Met Thr Thr Ala Pro Arg Gly Leu Gln Ser Gly Asp Arg Ala 
    210                 215                 220                 


Thr Trp Phe Gly Leu Tyr Tyr Asn Ile Ser Gly Ala Gly Phe Phe Leu 
225                 230                 235                 240 


His His Val Gly Leu Glu Leu Leu Val Asn His Lys Ala Leu Asp Pro 
                245                 250                 255     


Ala Arg Trp Thr Ile Gln Lys Val Phe Tyr Gln Gly Arg Tyr Tyr Asp 
            260                 265                 270         


Ser Leu Ala Gln Leu Glu Ala Gln Phe Glu Ala Gly Leu Val Asn Val 
        275                 280                 285             


Val Leu Ile Pro Asp Asn Gly Thr Gly Gly Ser Trp Ser Leu Lys Ser 
    290                 295                 300                 


Pro Val Pro Pro Gly Pro Ala Pro Pro Leu Gln Phe Tyr Pro Gln Gly 
305                 310                 315                 320 


Pro Arg Phe Ser Val Gln Gly Ser Arg Val Ala Ser Ser Leu Trp Thr 
                325                 330                 335     


Phe Ser Phe Gly Leu Gly Ala Phe Ser Gly Pro Arg Ile Phe Asp Val 
            340                 345                 350         


Arg Phe Gln Gly Glu Arg Leu Val Tyr Glu Ile Ser Leu Gln Glu Ala 
        355                 360                 365             


Leu Ala Ile Tyr Gly Gly Asn Ser Pro Ala Ala Met Thr Thr Arg Tyr 
    370                 375                 380                 


Val Asp Gly Gly Phe Gly Met Gly Lys Tyr Thr Thr Pro Leu Thr Arg 
385                 390                 395                 400 


Gly Val Asp Cys Pro Tyr Leu Ala Thr Tyr Val Asp Trp His Phe Leu 
                405                 410                 415     


Leu Glu Ser Gln Ala Pro Lys Thr Ile Arg Asp Ala Phe Cys Val Phe 
            420                 425                 430         


Glu Gln Asn Gln Gly Leu Pro Leu Arg Arg His His Ser Asp Leu Tyr 
        435                 440                 445             


Ser His Tyr Phe Gly Gly Leu Ala Glu Thr Val Leu Val Val Arg Ser 
    450                 455                 460                 


Met Ser Thr Leu Leu Asn Tyr Asp Tyr Val Trp Asp Thr Val Phe His 
465                 470                 475                 480 


Pro Ser Gly Ala Ile Glu Ile Arg Phe Tyr Ala Thr Gly Tyr Ile Ser 
                485                 490                 495     


Ser Ala Phe Leu Phe Gly Ala Thr Gly Lys Tyr Gly Asn Gln Val Ser 
            500                 505                 510         


Glu His Thr Leu Gly Thr Val His Thr His Ser Ala His Phe Lys Val 
        515                 520                 525             


Asp Leu Asp Val Ala Gly Leu Glu Asn Trp Val Trp Ala Glu Asp Met 
    530                 535                 540                 


Val Phe Val Pro Met Ala Val Pro Trp Ser Pro Glu His Gln Leu Gln 
545                 550                 555                 560 


Arg Leu Gln Val Thr Arg Lys Leu Leu Glu Met Glu Glu Gln Ala Ala 
                565                 570                 575     


Phe Leu Val Gly Ser Ala Thr Pro Arg Tyr Leu Tyr Leu Ala Ser Asn 
            580                 585                 590         


His Ser Asn Lys Trp Gly His Pro Arg Gly Tyr Arg Ile Gln Met Leu 
        595                 600                 605             


Ser Phe Ala Gly Glu Pro Leu Pro Gln Asn Ser Ser Met Ala Arg Gly 
    610                 615                 620                 


Phe Ser Trp Glu Arg Tyr Gln Leu Ala Val Thr Gln Arg Lys Glu Glu 
625                 630                 635                 640 


Glu Pro Ser Ser Ser Ser Val Phe Asn Gln Asn Asp Pro Trp Ala Pro 
                645                 650                 655     


Thr Val Asp Phe Ser Asp Phe Ile Asn Asn Glu Thr Ile Ala Gly Lys 
            660                 665                 670         


Asp Leu Val Ala Trp Val Thr Ala Gly Phe Leu His Ile Pro His Ala 
        675                 680                 685             


Glu Asp Ile Pro Asn Thr Val Thr Val Gly Asn Gly Val Gly Phe Phe 
    690                 695                 700                 


Leu Arg Pro Tyr Asn Phe Phe Asp Glu Asp Pro Ser Phe Tyr Ser Ala 
705                 710                 715                 720 


Asp Ser Ile Tyr Phe Arg Gly Asp Gln Asp Ala Gly Ala Cys Glu Val 
                725                 730                 735     


Asn Pro Leu Ala Cys Leu Pro Gln Ala Ala Ala Cys Ala Pro Asp Leu 
            740                 745                 750         


Pro Ala Phe Ser His Gly Gly Phe Ser His Asn 
        755                 760             


<210>  884
<211>  634
<212>  PRT
<213>  Homo Sapiens

<400>  884

Met Asn Gln Lys Thr Ile Leu Val Leu Leu Ile Leu Ala Val Ile Thr 
1               5                   10                  15      


Ile Phe Ala Leu Val Cys Val Leu Leu Val Gly Arg Gly Gly Asp Gly 
            20                  25                  30          


Gly Glu Pro Ser Gln Leu Pro His Cys Pro Ser Val Ser Pro Ser Ala 
        35                  40                  45              


Gln Pro Trp Thr His Pro Gly Gln Ser Gln Leu Phe Ala Asp Leu Ser 
    50                  55                  60                  


Arg Glu Glu Leu Thr Ala Val Met Arg Phe Leu Thr Gln Arg Leu Gly 
65                  70                  75                  80  


Pro Gly Leu Val Asp Ala Ala Gln Ala Arg Pro Ser Asp Asn Cys Val 
                85                  90                  95      


Phe Ser Val Glu Leu Gln Leu Pro Pro Lys Ala Ala Ala Leu Ala His 
            100                 105                 110         


Leu Asp Arg Gly Ser Pro Pro Pro Ala Arg Glu Ala Leu Ala Ile Val 
        115                 120                 125             


Phe Phe Gly Arg Gln Pro Gln Pro Asn Val Ser Glu Leu Val Val Gly 
    130                 135                 140                 


Pro Leu Pro His Pro Ser Tyr Met Arg Asp Val Thr Val Glu Arg His 
145                 150                 155                 160 


Gly Gly Pro Leu Pro Tyr His Arg Arg Pro Val Leu Phe Gln Glu Tyr 
                165                 170                 175     


Leu Asp Ile Asp Gln Met Ile Phe Asn Arg Glu Leu Pro Gln Ala Ser 
            180                 185                 190         


Gly Leu Leu His His Cys Cys Phe Tyr Lys His Arg Gly Arg Asn Leu 
        195                 200                 205             


Val Thr Met Thr Thr Ala Pro Arg Gly Leu Gln Ser Gly Asp Arg Ala 
    210                 215                 220                 


Thr Trp Phe Gly Leu Tyr Tyr Asn Ile Ser Gly Ala Gly Phe Phe Leu 
225                 230                 235                 240 


His His Val Gly Leu Glu Leu Leu Val Asn His Lys Ala Leu Asp Pro 
                245                 250                 255     


Ala Arg Trp Thr Ile Gln Lys Val Phe Tyr Gln Gly Arg Tyr Tyr Asp 
            260                 265                 270         


Ser Leu Ala Gln Leu Glu Ala Gln Phe Glu Ala Gly Leu Val Asn Val 
        275                 280                 285             


Val Leu Ile Pro Asp Asn Gly Thr Gly Gly Ser Trp Ser Leu Lys Ser 
    290                 295                 300                 


Pro Val Pro Pro Gly Pro Ala Pro Pro Leu Gln Phe Tyr Pro Gln Gly 
305                 310                 315                 320 


Pro Arg Phe Ser Val Gln Gly Ser Arg Val Ala Ser Ser Leu Trp Thr 
                325                 330                 335     


Phe Ser Phe Gly Leu Gly Ala Phe Ser Gly Pro Arg Ile Phe Asp Val 
            340                 345                 350         


Arg Phe Gln Gly Glu Arg Leu Val Tyr Glu Ile Ser Leu Gln Glu Ala 
        355                 360                 365             


Leu Ala Ile Tyr Gly Gly Asn Ser Pro Ala Ala Met Thr Thr Arg Tyr 
    370                 375                 380                 


Val Asp Gly Gly Phe Gly Met Gly Lys Tyr Thr Thr Pro Leu Thr Arg 
385                 390                 395                 400 


Gly Val Asp Cys Pro Tyr Leu Ala Thr Tyr Val Asp Trp His Phe Leu 
                405                 410                 415     


Leu Glu Ser Gln Ala Pro Lys Thr Ile Arg Asp Ala Phe Cys Val Phe 
            420                 425                 430         


Glu Gln Asn Gln Gly Leu Pro Leu Arg Arg His His Ser Asp Leu Tyr 
        435                 440                 445             


Ser His Tyr Phe Gly Gly Leu Ala Glu Thr Val Leu Val Val Arg Ser 
    450                 455                 460                 


Met Ser Thr Leu Leu Asn Tyr Asp Tyr Val Trp Asp Thr Val Phe His 
465                 470                 475                 480 


Pro Ser Gly Ala Ile Glu Ile Arg Phe Tyr Ala Thr Gly Tyr Ile Ser 
                485                 490                 495     


Ser Ala Phe Leu Phe Gly Ala Thr Gly Lys Tyr Gly Asn Gln Val Ser 
            500                 505                 510         


Glu His Thr Leu Gly Thr Val His Thr His Ser Ala His Phe Lys Val 
        515                 520                 525             


Asp Leu Asp Val Ala Gly Leu Glu Asn Trp Val Trp Ala Glu Asp Met 
    530                 535                 540                 


Val Phe Val Pro Met Ala Val Pro Trp Ser Pro Glu His Gln Leu Gln 
545                 550                 555                 560 


Arg Leu Gln Val Thr Arg Lys Leu Leu Glu Met Glu Glu Gln Ala Ala 
                565                 570                 575     


Phe Leu Val Gly Ser Ala Thr Pro Arg Tyr Leu Tyr Leu Ala Ser Asn 
            580                 585                 590         


His Ser Asn Lys Trp Gly His Pro Arg Gly Tyr Arg Ile Gln Met Leu 
        595                 600                 605             


Ser Phe Ala Gly Glu Pro Leu Pro Gln Asn Ser Ser Met Ala Arg Gly 
    610                 615                 620                 


Phe Ser Trp Glu Arg Ile Trp Trp Pro Gly 
625                 630                 


<210>  885
<211>  112
<212>  PRT
<213>  Homo Sapiens

<400>  885

Met Val Phe Val Pro Met Ala Val Pro Trp Ser Pro Glu His Gln Leu 
1               5                   10                  15      


Gln Arg Leu Gln Val Thr Arg Lys Leu Leu Glu Met Glu Glu Gln Ala 
            20                  25                  30          


Ala Phe Leu Val Gly Ser Ala Thr Pro Arg Tyr Leu Tyr Leu Ala Ser 
        35                  40                  45              


Asn His Ser Asn Lys Trp Gly His Pro Arg Gly Tyr Arg Ile Gln Met 
    50                  55                  60                  


Leu Ser Phe Ala Gly Glu Pro Leu Pro Gln Asn Ser Ser Met Ala Arg 
65                  70                  75                  80  


Gly Phe Ser Trp Glu Arg Tyr Gln Leu Ala Val Thr Gln Arg Lys Glu 
                85                  90                  95      


Glu Glu Pro Ser Ser Ser Ser Val Phe Asn Gln Asn Asp Pro Trp Ala 
            100                 105                 110         


<210>  886
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  886

Met Val Phe Val Pro Met Ala Val Pro Trp Ser Pro Glu His Gln Leu 
1               5                   10                  15      


Gln Arg Leu Gln Val Thr Arg Lys Leu Leu Glu Met Glu Glu Gln Ala 
            20                  25                  30          


Ala Phe Leu Val Gly Ser Ala Thr Pro Arg Tyr Leu Tyr Leu Ala Ser 
        35                  40                  45              


Asn His Ser Asn Lys Trp Gly His Pro Arg Gly Tyr Arg Ile Gln Met 
    50                  55                  60                  


Leu Ser Phe Ala Gly Glu Pro Leu Pro Gln Asn Ser Ser Met Ala Arg 
65                  70                  75                  80  


Gly Phe Ser Trp Glu Arg Tyr Gln Leu Ala Val Thr Gln Arg Lys Glu 
                85                  90                  95      


Glu Glu Pro Ser Ser Ser Ser Val Phe Asn Gln Asn Asp Pro Trp Ala 
            100                 105                 110         


Pro Thr Val Asp Phe Ser Asp Phe Ile Asn Asn Glu Thr Ile Ala Gly 
        115                 120                 125             


Lys Asp Leu Val Ala Trp Val Thr Ala Gly Phe Leu His Ile Pro His 
    130                 135                 140                 


Ala Glu Asp Ile Pro Asn Thr Val 
145                 150         


<210>  887
<211>  220
<212>  PRT
<213>  Homo Sapiens

<400>  887

Met Val Phe Val Pro Met Ala Val Pro Trp Ser Pro Glu His Gln Leu 
1               5                   10                  15      


Gln Arg Leu Gln Val Thr Arg Lys Leu Leu Glu Met Glu Glu Gln Ala 
            20                  25                  30          


Ala Phe Leu Val Gly Ser Ala Thr Pro Arg Tyr Leu Tyr Leu Ala Ser 
        35                  40                  45              


Asn His Ser Asn Lys Trp Gly His Pro Arg Gly Tyr Arg Ile Gln Met 
    50                  55                  60                  


Leu Ser Phe Ala Gly Glu Pro Leu Pro Gln Asn Ser Ser Met Ala Arg 
65                  70                  75                  80  


Gly Phe Ser Trp Glu Arg Tyr Gln Leu Ala Val Thr Gln Arg Lys Glu 
                85                  90                  95      


Glu Glu Pro Ser Ser Ser Ser Val Phe Asn Gln Asn Asp Pro Trp Ala 
            100                 105                 110         


Pro Thr Val Asp Phe Ser Asp Phe Ile Asn Asn Glu Thr Ile Ala Gly 
        115                 120                 125             


Lys Asp Leu Val Ala Trp Val Thr Ala Gly Phe Leu His Ile Pro His 
    130                 135                 140                 


Ala Glu Asp Ile Pro Asn Thr Val Thr Val Gly Asn Gly Val Gly Phe 
145                 150                 155                 160 


Phe Leu Arg Pro Tyr Asn Phe Phe Asp Glu Asp Pro Ser Phe Tyr Ser 
                165                 170                 175     


Ala Asp Ser Ile Tyr Phe Arg Gly Asp Gln Asp Ala Gly Ala Cys Glu 
            180                 185                 190         


Val Asn Pro Leu Ala Cys Leu Pro Gln Ala Ala Ala Cys Ala Pro Asp 
        195                 200                 205             


Leu Pro Ala Phe Ser His Gly Gly Phe Ser His Asn 
    210                 215                 220 


<210>  888
<211>  220
<212>  PRT
<213>  Homo Sapiens

<400>  888

Met Val Phe Val Pro Met Ala Val Pro Trp Ser Pro Glu His Gln Leu 
1               5                   10                  15      


Gln Arg Leu Gln Val Thr Arg Lys Leu Leu Glu Met Glu Glu Gln Ala 
            20                  25                  30          


Ala Phe Leu Val Gly Ser Ala Thr Pro Arg Tyr Leu Tyr Leu Ala Ser 
        35                  40                  45              


Asn His Ser Asn Lys Trp Gly His Pro Arg Gly Tyr Arg Ile Gln Met 
    50                  55                  60                  


Leu Ser Phe Ala Gly Glu Pro Leu Pro Gln Asn Ser Ser Met Ala Arg 
65                  70                  75                  80  


Gly Phe Ser Trp Glu Arg Tyr Gln Leu Ala Val Thr Gln Arg Lys Glu 
                85                  90                  95      


Glu Glu Pro Ser Ser Ser Ser Val Phe Asn Gln Asn Asp Pro Trp Ala 
            100                 105                 110         


Pro Thr Val Asp Phe Ser Asp Phe Ile Asn Asn Glu Thr Ile Ala Gly 
        115                 120                 125             


Lys Asp Leu Val Ala Trp Val Thr Ala Gly Phe Leu His Ile Pro His 
    130                 135                 140                 


Ala Glu Asp Ile Pro Asn Thr Val Thr Val Gly Asn Gly Val Gly Phe 
145                 150                 155                 160 


Phe Leu Arg Pro Tyr Asn Phe Phe Asp Glu Asp Pro Ser Phe Tyr Ser 
                165                 170                 175     


Ala Asp Ser Ile Tyr Phe Arg Gly Asp Gln Asp Ala Gly Ala Cys Glu 
            180                 185                 190         


Val Asn Pro Leu Ala Cys Leu Pro Gln Ala Ala Ala Cys Ala Pro Asp 
        195                 200                 205             


Leu Pro Ala Phe Ser His Gly Gly Phe Ser His Asn 
    210                 215                 220 


<210>  889
<211>  144
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  889

Xaa Tyr Asp Tyr Val Trp Asp Thr Val Phe His Pro Ser Gly Ala Ile 
1               5                   10                  15      


Glu Ile Arg Phe Tyr Ala Thr Gly Tyr Ile Ser Ser Ala Phe Leu Phe 
            20                  25                  30          


Gly Ala Thr Gly Lys Tyr Gly Asn Gln Val Ser Glu His Thr Leu Gly 
        35                  40                  45              


Thr Val His Thr His Ser Ala His Phe Lys Val Asp Leu Asp Val Ala 
    50                  55                  60                  


Gly Asp Pro Glu Ala Ala Gly Asp Gly Gly Ala Gly Arg Leu Pro Arg 
65                  70                  75                  80  


Gly Lys Arg His Pro Ser Leu Pro Val Pro Gly Gln Gln Pro Gln Gln 
                85                  90                  95      


Gln Val Gly Ser Pro Pro Gly Leu Pro His Pro Asp Ala Gln Leu Cys 
            100                 105                 110         


Trp Arg Ala Ala Ala Pro Lys Gln Leu His Gly Glu Arg Leu Gln Leu 
        115                 120                 125             


Gly Glu Val Pro Ala Gly Cys Asp Pro Ala Glu Gly Gly Gly Ala Gln 
    130                 135                 140                 


<210>  890
<211>  164
<212>  PRT
<213>  Homo Sapiens

<400>  890

Met Ser Val Leu Thr Pro Leu Leu Leu Arg Gly Leu Thr Gly Ser Ala 
1               5                   10                  15      


Arg Arg Leu Pro Val Pro Arg Ala Lys Ile His Ser Leu Pro Pro Glu 
            20                  25                  30          


Gly Lys Leu Gly Ile Met Gly Lys Glu Asn Gly Ile Gly Ser Arg Arg 
        35                  40                  45              


Ile Cys Asn His His Arg Glu Leu Trp Glu Ala Gly Lys Met Glu Pro 
    50                  55                  60                  


Asn Gln Cys Val Gly Trp Arg Cys Gly Ser Gly Ala Ala Gly Leu Ser 
65                  70                  75                  80  


Tyr Arg Ser Gln Val Arg Arg Pro Gly Val Pro Ala Pro Ala Thr Gly 
                85                  90                  95      


Leu Glu Ala His Ser Leu Thr Thr Pro Lys Gly Ile Pro Leu Leu Gly 
            100                 105                 110         


Leu Leu Pro Arg Arg Gly Asn Glu Glu Gly Leu Ala Ser Gly Arg Thr 
        115                 120                 125             


Ala Ile Gly Asn Pro Glu Ala Val Gly Ser Ala Ala Leu Phe Lys Asp 
    130                 135                 140                 


Gly Gly Gly Gly Thr Ser Ala Ala Glu Ala Gly Ala Ala Gly Gln Arg 
145                 150                 155                 160 


Leu Arg Arg Cys 
                


<210>  891
<211>  235
<212>  PRT
<213>  Homo Sapiens

<400>  891

Met Leu Lys Cys His Val Phe Arg Cys Glu Ala Pro Ala Lys Asn Ile 
1               5                   10                  15      


Ala Thr Ser Leu His Glu Ile Cys Ser Lys Ile Met Ala Glu Arg Arg 
            20                  25                  30          


Asn Ala Arg Cys Leu Val Asn Gly Leu Ser Leu Asp His Ser Lys Leu 
        35                  40                  45              


Val Asp Val Pro Phe Gln Val Glu Phe Pro Ala Pro Lys Asn Glu Leu 
    50                  55                  60                  


Val Gln Lys Phe Gln Val Tyr Tyr Leu Gly Asn Val Pro Val Ala Lys 
65                  70                  75                  80  


Pro Val Gly Val Asp Val Ile Asn Gly Ala Leu Glu Ser Val Leu Ser 
                85                  90                  95      


Ser Ser Ser Arg Glu Gln Trp Thr Pro Ser His Val Ser Val Ala Pro 
            100                 105                 110         


Ala Thr Leu Thr Ile Leu His Gln Gln Thr Glu Ala Val Leu Gly Glu 
        115                 120                 125             


Cys Arg Val Arg Phe Leu Ser Phe Leu Ala Val Gly Arg Asp Val His 
    130                 135                 140                 


Thr Phe Ala Phe Ile Met Ala Ala Gly Pro Ala Ser Phe Cys Cys His 
145                 150                 155                 160 


Met Phe Trp Cys Glu Pro Asn Ala Ala Ser Leu Ser Glu Ala Val Gln 
                165                 170                 175     


Ala Ala Cys Met Leu Arg Tyr Gln Lys Cys Leu Asp Ala Arg Ser Gln 
            180                 185                 190         


Ala Ser Thr Ser Cys Leu Pro Ala Pro Pro Ala Glu Ser Val Ala Arg 
        195                 200                 205             


Arg Val Gly Trp Thr Val Arg Arg Gly Val Gln Ser Leu Trp Gly Ser 
    210                 215                 220                 


Leu Lys Pro Lys Arg Leu Gly Ala His Thr Pro 
225                 230                 235 


<210>  892
<211>  87
<212>  PRT
<213>  Homo Sapiens

<400>  892

Met Arg Val Gln Asp Thr Ser Gly Thr Tyr Tyr Trp His Ile Pro Thr 
1               5                   10                  15      


Gly Thr Thr Gln Trp Glu Pro Pro Gly Arg Ala Ser Pro Ser Gln Gly 
            20                  25                  30          


Ser Ser Pro Gln Glu Glu Ser Gln Leu Thr Trp Thr Gly Phe Ala His 
        35                  40                  45              


Gly Glu Gly Phe Glu Asp Gly Glu Phe Trp Lys Asp Glu Pro Ser Asp 
    50                  55                  60                  


Glu Ala Pro Met Glu Leu Gly Leu Lys Glu Pro Glu Glu Gly Thr Leu 
65                  70                  75                  80  


Thr Phe Pro Ala Gln Ser Leu 
                85          


<210>  893
<211>  262
<212>  PRT
<213>  Homo Sapiens

<400>  893

Met Arg Val Gln Asp Thr Ser Gly Thr Tyr Tyr Trp His Ile Pro Thr 
1               5                   10                  15      


Gly Thr Thr Gln Trp Glu Pro Pro Gly Arg Ala Ser Pro Ser Gln Gly 
            20                  25                  30          


Ser Ser Pro Gln Glu Glu Ser Gln Leu Thr Trp Thr Gly Phe Ala His 
        35                  40                  45              


Gly Glu Gly Phe Glu Asp Gly Glu Phe Trp Lys Asp Glu Pro Ser Asp 
    50                  55                  60                  


Glu Ala Pro Met Glu Leu Gly Leu Lys Glu Pro Glu Glu Gly Thr Leu 
65                  70                  75                  80  


Thr Phe Pro Ala Gln Ser Leu Ser Pro Glu Pro Leu Pro Gln Glu Glu 
                85                  90                  95      


Glu Lys Leu Pro Pro Arg Asn Thr Asn Pro Gly Ile Lys Cys Phe Ala 
            100                 105                 110         


Val Arg Ser Leu Gly Trp Val Glu Met Thr Glu Glu Glu Leu Ala Pro 
        115                 120                 125             


Gly Arg Ser Ser Val Ala Val Asn Asn Cys Ile Arg Gln Leu Ser Tyr 
    130                 135                 140                 


His Lys Asn Asn Leu His Asp Pro Met Ser Gly Gly Trp Gly Glu Gly 
145                 150                 155                 160 


Lys Asp Leu Leu Leu Gln Leu Glu Asp Glu Thr Leu Lys Leu Val Glu 
                165                 170                 175     


Pro Gln Ser Gln Ala Leu Leu His Ala Gln Pro Ile Ile Ser Ile Arg 
            180                 185                 190         


Val Trp Gly Val Gly Arg Asp Ser Gly Arg Asp Phe Ala Tyr Val Ala 
        195                 200                 205             


Arg Asp Lys Leu Thr Gln Met Leu Lys Cys His Val Phe Arg Cys Glu 
    210                 215                 220                 


Ala Pro Ala Lys Asn Ile Ala Thr Ser Leu His Glu Ile Cys Ser Lys 
225                 230                 235                 240 


Ile Met Ala Glu Arg Arg Asn Ala Arg Cys Leu Val Asn Gly Leu Ser 
                245                 250                 255     


Leu Asp His Ser Lys Leu 
            260         


<210>  894
<211>  451
<212>  PRT
<213>  Homo Sapiens

<400>  894

Met Arg Val Gln Asp Thr Ser Gly Thr Tyr Tyr Trp His Ile Pro Thr 
1               5                   10                  15      


Gly Thr Thr Gln Trp Glu Pro Pro Gly Arg Ala Ser Pro Ser Gln Gly 
            20                  25                  30          


Ser Ser Pro Gln Glu Glu Ser Gln Leu Thr Trp Thr Gly Phe Ala His 
        35                  40                  45              


Gly Glu Gly Phe Glu Asp Gly Glu Phe Trp Lys Asp Glu Pro Ser Asp 
    50                  55                  60                  


Glu Ala Pro Met Glu Leu Gly Leu Lys Glu Pro Glu Glu Gly Thr Leu 
65                  70                  75                  80  


Thr Phe Pro Ala Gln Ser Leu Ser Pro Glu Pro Leu Pro Gln Glu Glu 
                85                  90                  95      


Glu Lys Leu Pro Pro Arg Asn Thr Asn Pro Gly Ile Lys Cys Phe Ala 
            100                 105                 110         


Val Arg Ser Leu Gly Trp Val Glu Met Thr Glu Glu Glu Leu Ala Pro 
        115                 120                 125             


Gly Arg Ser Ser Val Ala Val Asn Asn Cys Ile Arg Gln Leu Ser Tyr 
    130                 135                 140                 


His Lys Asn Asn Leu His Asp Pro Met Ser Gly Gly Trp Gly Glu Gly 
145                 150                 155                 160 


Lys Asp Leu Leu Leu Gln Leu Glu Asp Glu Thr Leu Lys Leu Val Glu 
                165                 170                 175     


Pro Gln Ser Gln Ala Leu Leu His Ala Gln Pro Ile Ile Ser Ile Arg 
            180                 185                 190         


Val Trp Gly Val Gly Arg Asp Ser Gly Arg Glu Arg Asp Phe Ala Tyr 
        195                 200                 205             


Val Ala Arg Asp Lys Leu Thr Gln Met Leu Lys Cys His Val Phe Arg 
    210                 215                 220                 


Cys Glu Ala Pro Ala Lys Asn Ile Ala Thr Ser Leu His Glu Ile Cys 
225                 230                 235                 240 


Ser Lys Ile Met Ala Glu Arg Arg Asn Ala Arg Cys Leu Val Asn Gly 
                245                 250                 255     


Leu Ser Leu Asp His Ser Lys Leu Val Asp Val Pro Phe Gln Val Glu 
            260                 265                 270         


Phe Pro Ala Pro Lys Asn Glu Leu Val Gln Lys Phe Gln Val Tyr Tyr 
        275                 280                 285             


Leu Gly Asn Val Pro Val Ala Lys Pro Val Gly Val Asp Val Ile Asn 
    290                 295                 300                 


Gly Ala Leu Glu Ser Val Leu Ser Ser Ser Ser Arg Glu Gln Trp Thr 
305                 310                 315                 320 


Pro Ser His Val Ser Val Ala Pro Ala Thr Leu Thr Ile Leu His Gln 
                325                 330                 335     


Gln Thr Glu Ala Val Leu Gly Glu Cys Arg Val Arg Phe Leu Ser Phe 
            340                 345                 350         


Leu Ala Val Gly Arg Asp Val His Thr Phe Ala Phe Ile Met Ala Ala 
        355                 360                 365             


Gly Pro Ala Ser Phe Cys Cys His Met Phe Trp Cys Glu Pro Asn Ala 
    370                 375                 380                 


Ala Ser Leu Ser Glu Ala Val Gln Ala Ala Cys Met Leu Arg Tyr Gln 
385                 390                 395                 400 


Lys Cys Leu Asp Ala Arg Ser Gln Ala Ser Thr Ser Cys Leu Pro Ala 
                405                 410                 415     


Pro Pro Ala Glu Ser Val Ala Arg Arg Val Gly Trp Thr Val Arg Arg 
            420                 425                 430         


Gly Val Gln Ser Leu Trp Gly Ser Leu Lys Pro Lys Arg Leu Gly Ala 
        435                 440                 445             


His Thr Pro 
    450     


<210>  895
<211>  451
<212>  PRT
<213>  Homo Sapiens

<400>  895

Met Arg Val Gln Asp Thr Ser Gly Thr Tyr Tyr Trp His Ile Pro Thr 
1               5                   10                  15      


Gly Thr Thr Gln Trp Glu Pro Pro Gly Arg Ala Ser Pro Ser Gln Gly 
            20                  25                  30          


Ser Ser Pro Gln Glu Glu Ser Gln Leu Thr Trp Thr Gly Phe Ala His 
        35                  40                  45              


Gly Glu Gly Phe Glu Asp Gly Glu Phe Trp Lys Asp Glu Pro Ser Asp 
    50                  55                  60                  


Glu Ala Pro Met Glu Leu Gly Leu Lys Glu Pro Glu Glu Gly Thr Leu 
65                  70                  75                  80  


Thr Phe Pro Ala Gln Ser Leu Ser Pro Glu Pro Leu Pro Gln Glu Glu 
                85                  90                  95      


Glu Lys Leu Pro Pro Arg Asn Thr Asn Pro Gly Ile Lys Cys Phe Ala 
            100                 105                 110         


Val Arg Ser Leu Gly Trp Val Glu Met Thr Glu Glu Glu Leu Ala Pro 
        115                 120                 125             


Gly Arg Ser Ser Val Ala Val Asn Asn Cys Ile Arg Gln Leu Ser Tyr 
    130                 135                 140                 


His Lys Asn Asn Leu His Asp Pro Met Ser Gly Gly Trp Gly Glu Gly 
145                 150                 155                 160 


Lys Asp Leu Leu Leu Gln Leu Glu Asp Glu Thr Leu Lys Leu Val Glu 
                165                 170                 175     


Pro Gln Ser Gln Ala Leu Leu His Ala Gln Pro Ile Ile Ser Ile Arg 
            180                 185                 190         


Val Trp Gly Val Gly Arg Asp Ser Gly Arg Glu Arg Asp Phe Ala Tyr 
        195                 200                 205             


Val Ala Arg Asp Lys Leu Thr Gln Met Leu Lys Cys His Val Phe Arg 
    210                 215                 220                 


Cys Glu Ala Pro Ala Lys Asn Ile Ala Thr Ser Leu His Glu Ile Cys 
225                 230                 235                 240 


Ser Lys Ile Met Ala Glu Arg Arg Asn Ala Arg Cys Leu Val Asn Gly 
                245                 250                 255     


Leu Ser Leu Asp His Ser Lys Leu Val Asp Val Pro Phe Gln Val Glu 
            260                 265                 270         


Phe Pro Ala Pro Lys Asn Glu Leu Val Gln Lys Phe Gln Val Tyr Tyr 
        275                 280                 285             


Leu Gly Asn Val Pro Val Ala Lys Pro Val Gly Val Asp Val Ile Asn 
    290                 295                 300                 


Gly Ala Leu Glu Ser Val Leu Ser Ser Ser Ser Arg Glu Gln Trp Thr 
305                 310                 315                 320 


Pro Ser His Val Ser Val Ala Pro Ala Thr Leu Thr Ile Leu His Gln 
                325                 330                 335     


Gln Thr Glu Ala Val Leu Gly Glu Cys Arg Val Arg Phe Leu Ser Phe 
            340                 345                 350         


Leu Ala Val Gly Arg Asp Val His Thr Phe Ala Phe Ile Met Ala Ala 
        355                 360                 365             


Gly Pro Ala Ser Phe Cys Cys His Met Phe Trp Cys Glu Pro Asn Ala 
    370                 375                 380                 


Ala Ser Leu Ser Glu Ala Val Gln Ala Ala Cys Met Leu Arg Tyr Gln 
385                 390                 395                 400 


Lys Cys Leu Asp Ala Arg Ser Gln Ala Ser Thr Ser Cys Leu Pro Ala 
                405                 410                 415     


Pro Pro Ala Glu Ser Val Ala Arg Arg Val Gly Trp Thr Val Arg Arg 
            420                 425                 430         


Gly Val Gln Ser Leu Trp Gly Ser Leu Lys Pro Lys Arg Leu Gly Ala 
        435                 440                 445             


His Thr Pro 
    450     


<210>  896
<211>  451
<212>  PRT
<213>  Homo Sapiens

<400>  896

Met Arg Val Gln Asp Thr Ser Gly Thr Tyr Tyr Trp His Ile Pro Thr 
1               5                   10                  15      


Gly Thr Thr Gln Trp Glu Pro Pro Gly Arg Ala Ser Pro Ser Gln Gly 
            20                  25                  30          


Ser Ser Pro Gln Glu Glu Ser Gln Leu Thr Trp Thr Gly Phe Ala His 
        35                  40                  45              


Gly Glu Gly Phe Glu Asp Gly Glu Phe Trp Lys Asp Glu Pro Ser Asp 
    50                  55                  60                  


Glu Ala Pro Met Glu Leu Gly Leu Lys Glu Pro Glu Glu Gly Thr Leu 
65                  70                  75                  80  


Thr Phe Pro Ala Gln Ser Leu Ser Pro Glu Pro Leu Pro Gln Glu Glu 
                85                  90                  95      


Glu Lys Leu Pro Pro Arg Asn Thr Asn Pro Gly Ile Lys Cys Phe Ala 
            100                 105                 110         


Val Arg Ser Leu Gly Trp Val Glu Met Thr Glu Glu Glu Leu Ala Pro 
        115                 120                 125             


Gly Arg Ser Ser Val Ala Val Asn Asn Cys Ile Arg Gln Leu Ser Tyr 
    130                 135                 140                 


His Lys Asn Asn Leu His Asp Pro Met Ser Gly Gly Trp Gly Glu Gly 
145                 150                 155                 160 


Lys Asp Leu Leu Leu Gln Leu Glu Asp Glu Thr Leu Lys Leu Val Glu 
                165                 170                 175     


Pro Gln Ser Gln Ala Leu Leu His Ala Gln Pro Ile Ile Ser Ile Arg 
            180                 185                 190         


Val Trp Gly Val Gly Arg Asp Ser Gly Arg Glu Arg Asp Phe Ala Tyr 
        195                 200                 205             


Val Ala Arg Asp Lys Leu Thr Gln Met Leu Lys Cys His Val Phe Arg 
    210                 215                 220                 


Cys Glu Ala Pro Ala Lys Asn Ile Ala Thr Ser Leu His Glu Ile Cys 
225                 230                 235                 240 


Ser Lys Ile Met Ala Glu Arg Arg Asn Ala Arg Cys Leu Val Asn Gly 
                245                 250                 255     


Leu Ser Leu Asp His Ser Lys Leu Val Asp Val Pro Phe Gln Val Glu 
            260                 265                 270         


Phe Pro Ala Pro Lys Asn Glu Leu Val Gln Lys Phe Gln Val Tyr Tyr 
        275                 280                 285             


Leu Gly Asn Val Pro Val Ala Lys Pro Val Gly Val Asp Val Ile Asn 
    290                 295                 300                 


Gly Ala Leu Glu Ser Val Leu Ser Ser Ser Ser Arg Glu Gln Trp Thr 
305                 310                 315                 320 


Pro Ser His Val Ser Val Ala Pro Ala Thr Leu Thr Ile Leu His Gln 
                325                 330                 335     


Gln Thr Glu Ala Val Leu Gly Glu Cys Arg Val Arg Phe Leu Ser Phe 
            340                 345                 350         


Leu Ala Val Gly Arg Asp Val His Thr Phe Ala Phe Ile Met Ala Ala 
        355                 360                 365             


Gly Pro Ala Ser Phe Cys Cys His Met Phe Trp Cys Glu Pro Asn Ala 
    370                 375                 380                 


Ala Ser Leu Ser Glu Ala Val Gln Ala Ala Cys Met Leu Arg Tyr Gln 
385                 390                 395                 400 


Lys Cys Leu Asp Ala Arg Ser Gln Ala Ser Thr Ser Cys Leu Pro Ala 
                405                 410                 415     


Pro Pro Ala Glu Ser Val Ala Arg Arg Val Gly Trp Thr Val Arg Arg 
            420                 425                 430         


Gly Val Gln Ser Leu Trp Gly Ser Leu Lys Pro Lys Arg Leu Gly Ala 
        435                 440                 445             


His Thr Pro 
    450     


<210>  897
<211>  451
<212>  PRT
<213>  Homo Sapiens

<400>  897

Met Arg Val Gln Asp Thr Ser Gly Thr Tyr Tyr Trp His Ile Pro Thr 
1               5                   10                  15      


Gly Thr Thr Gln Trp Glu Pro Pro Gly Arg Ala Ser Pro Ser Gln Gly 
            20                  25                  30          


Ser Ser Pro Gln Glu Glu Ser Gln Leu Thr Trp Thr Gly Phe Ala His 
        35                  40                  45              


Gly Glu Gly Phe Glu Asp Gly Glu Phe Trp Lys Asp Glu Pro Ser Asp 
    50                  55                  60                  


Glu Ala Pro Met Glu Leu Gly Leu Lys Glu Pro Glu Glu Gly Thr Leu 
65                  70                  75                  80  


Thr Phe Pro Ala Gln Ser Leu Ser Pro Glu Pro Leu Pro Gln Glu Glu 
                85                  90                  95      


Glu Lys Leu Pro Pro Arg Asn Thr Asn Pro Gly Ile Lys Cys Phe Ala 
            100                 105                 110         


Val Arg Ser Leu Gly Trp Val Glu Met Thr Glu Glu Glu Leu Ala Pro 
        115                 120                 125             


Gly Arg Ser Ser Val Ala Val Asn Asn Cys Ile Arg Gln Leu Ser Tyr 
    130                 135                 140                 


His Lys Asn Asn Leu His Asp Pro Met Ser Gly Gly Trp Gly Glu Gly 
145                 150                 155                 160 


Lys Asp Leu Leu Leu Gln Leu Glu Asp Glu Thr Leu Lys Leu Val Glu 
                165                 170                 175     


Pro Gln Ser Gln Ala Leu Leu His Ala Gln Pro Ile Ile Ser Ile Arg 
            180                 185                 190         


Val Trp Gly Val Gly Arg Asp Ser Gly Ser Asn Arg Asp Phe Ala Tyr 
        195                 200                 205             


Val Ala Arg Asp Lys Leu Thr Gln Met Leu Lys Cys His Val Phe Arg 
    210                 215                 220                 


Cys Glu Ala Pro Ala Lys Asn Ile Ala Thr Ser Leu His Glu Ile Cys 
225                 230                 235                 240 


Ser Lys Ile Met Ala Glu Arg Arg Asn Ala Arg Cys Leu Val Asn Gly 
                245                 250                 255     


Leu Ser Leu Asp His Ser Lys Leu Val Asp Val Pro Phe Gln Val Glu 
            260                 265                 270         


Phe Pro Ala Pro Lys Asn Glu Leu Val Gln Lys Phe Gln Val Tyr Tyr 
        275                 280                 285             


Leu Gly Asn Val Pro Val Ala Lys Pro Val Gly Val Asp Val Ile Asn 
    290                 295                 300                 


Gly Ala Leu Glu Ser Val Leu Ser Ser Ser Ser Arg Glu Gln Trp Thr 
305                 310                 315                 320 


Pro Ser His Val Ser Val Ala Pro Ala Thr Leu Thr Ile Leu His Gln 
                325                 330                 335     


Gln Thr Glu Ala Val Leu Gly Glu Cys Arg Val Arg Phe Leu Ser Phe 
            340                 345                 350         


Leu Ala Val Gly Arg Asp Val His Thr Phe Ala Phe Ile Met Ala Ala 
        355                 360                 365             


Gly Pro Ala Ser Phe Cys Cys His Met Phe Trp Cys Glu Pro Asn Ala 
    370                 375                 380                 


Ala Ser Leu Ser Glu Ala Val Gln Ala Ala Cys Met Leu Arg Tyr Gln 
385                 390                 395                 400 


Lys Cys Leu Asp Ala Arg Ser Gln Ala Ser Thr Ser Cys Leu Pro Ala 
                405                 410                 415     


Pro Pro Ala Glu Ser Val Ala Arg Arg Val Gly Trp Thr Val Arg Arg 
            420                 425                 430         


Gly Val Gln Ser Leu Trp Gly Ser Leu Lys Pro Lys Arg Leu Gly Ala 
        435                 440                 445             


His Thr Pro 
    450     


<210>  898
<211>  451
<212>  PRT
<213>  Homo Sapiens

<400>  898

Met Arg Val Gln Asp Thr Ser Gly Thr Tyr Tyr Trp His Ile Pro Thr 
1               5                   10                  15      


Gly Thr Thr Gln Trp Glu Pro Pro Gly Arg Ala Ser Pro Ser Gln Gly 
            20                  25                  30          


Ser Ser Pro Gln Glu Glu Ser Gln Leu Thr Trp Thr Gly Phe Ala His 
        35                  40                  45              


Gly Glu Gly Phe Glu Asp Gly Glu Phe Trp Lys Asp Glu Pro Ser Asp 
    50                  55                  60                  


Glu Ala Pro Met Glu Leu Gly Leu Lys Glu Pro Glu Glu Gly Thr Leu 
65                  70                  75                  80  


Thr Phe Pro Ala Gln Ser Leu Ser Pro Glu Pro Leu Pro Gln Glu Glu 
                85                  90                  95      


Glu Lys Leu Pro Pro Arg Asn Thr Asn Pro Gly Ile Lys Cys Phe Ala 
            100                 105                 110         


Val Arg Ser Leu Gly Trp Val Glu Met Thr Glu Glu Glu Leu Ala Pro 
        115                 120                 125             


Gly Arg Ser Ser Val Ala Val Asn Asn Cys Ile Arg Gln Leu Ser Tyr 
    130                 135                 140                 


His Lys Asn Asn Leu His Asp Pro Met Ser Gly Gly Trp Gly Glu Gly 
145                 150                 155                 160 


Lys Asp Leu Leu Leu Gln Leu Glu Asp Glu Thr Leu Lys Leu Val Glu 
                165                 170                 175     


Pro Gln Ser Gln Ala Leu Leu His Ala Gln Pro Ile Ile Ser Ile Arg 
            180                 185                 190         


Val Trp Gly Val Gly Arg Asp Ser Gly Ser Asn Arg Asp Phe Ala Tyr 
        195                 200                 205             


Val Ala Arg Asp Lys Leu Thr Gln Met Leu Lys Cys His Val Phe Arg 
    210                 215                 220                 


Cys Glu Ala Pro Ala Lys Asn Ile Ala Thr Ser Leu His Glu Ile Cys 
225                 230                 235                 240 


Ser Lys Ile Met Ala Glu Arg Arg Asn Ala Arg Cys Leu Val Asn Gly 
                245                 250                 255     


Leu Ser Leu Asp His Ser Lys Leu Val Asp Val Pro Phe Gln Val Glu 
            260                 265                 270         


Phe Pro Ala Pro Lys Asn Glu Leu Val Gln Lys Phe Gln Val Tyr Tyr 
        275                 280                 285             


Leu Gly Asn Val Pro Val Ala Lys Pro Val Gly Val Asp Val Ile Asn 
    290                 295                 300                 


Gly Ala Leu Glu Ser Val Leu Ser Ser Ser Ser Arg Glu Gln Trp Thr 
305                 310                 315                 320 


Pro Ser His Val Ser Val Ala Pro Ala Thr Leu Thr Ile Leu His Gln 
                325                 330                 335     


Gln Thr Glu Ala Val Leu Gly Glu Cys Arg Val Arg Phe Leu Ser Phe 
            340                 345                 350         


Leu Ala Val Gly Arg Asp Val His Thr Phe Ala Phe Ile Met Ala Ala 
        355                 360                 365             


Gly Pro Ala Ser Phe Cys Cys His Met Phe Trp Cys Glu Pro Asn Ala 
    370                 375                 380                 


Ala Ser Leu Ser Glu Ala Val Gln Ala Ala Cys Met Leu Arg Tyr Gln 
385                 390                 395                 400 


Lys Cys Leu Asp Ala Arg Ser Gln Ala Ser Thr Ser Cys Leu Pro Ala 
                405                 410                 415     


Pro Pro Ala Glu Ser Val Ala Arg Arg Val Gly Trp Thr Val Arg Arg 
            420                 425                 430         


Gly Val Gln Ser Leu Trp Gly Ser Leu Lys Pro Lys Arg Leu Gly Ala 
        435                 440                 445             


His Thr Pro 
    450     


<210>  899
<211>  488
<212>  PRT
<213>  Homo Sapiens

<400>  899

Met Ser Ala Met Phe Ser Gln Asp Phe Phe Leu Ala Ile Ile Leu Gln 
1               5                   10                  15      


Asp Ser Ser Ala Asp Ser Phe Trp Asn Pro Asn Ala Phe Glu Thr Asp 
            20                  25                  30          


Ser Asp Leu Pro Ala Gly Trp Met Arg Val Gln Asp Thr Ser Gly Thr 
        35                  40                  45              


Tyr Tyr Trp His Ile Pro Thr Gly Thr Thr Gln Trp Glu Pro Pro Gly 
    50                  55                  60                  


Arg Ala Ser Pro Ser Gln Gly Ser Ser Pro Gln Glu Glu Ser Gln Leu 
65                  70                  75                  80  


Thr Trp Thr Gly Phe Ala His Gly Glu Gly Phe Glu Asp Gly Glu Phe 
                85                  90                  95      


Trp Lys Asp Glu Pro Ser Asp Glu Ala Pro Met Glu Leu Gly Leu Lys 
            100                 105                 110         


Glu Pro Glu Glu Gly Thr Leu Thr Phe Pro Ala Gln Ser Leu Ser Pro 
        115                 120                 125             


Glu Pro Leu Pro Gln Glu Glu Glu Lys Leu Pro Pro Arg Asn Thr Asn 
    130                 135                 140                 


Pro Gly Ile Lys Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu Met 
145                 150                 155                 160 


Thr Glu Glu Glu Leu Ala Pro Gly Arg Ser Ser Val Ala Val Asn Asn 
                165                 170                 175     


Cys Ile Arg Gln Leu Ser Tyr His Lys Asn Asn Leu His Asp Pro Met 
            180                 185                 190         


Ser Gly Gly Trp Gly Glu Gly Lys Asp Leu Leu Leu Gln Leu Glu Asp 
        195                 200                 205             


Glu Thr Leu Lys Leu Val Glu Pro Gln Ser Gln Ala Leu Leu His Ala 
    210                 215                 220                 


Gln Pro Ile Ile Ser Ile Arg Val Trp Gly Val Gly Arg Asp Ser Gly 
225                 230                 235                 240 


Arg Asp Phe Ala Tyr Val Ala Arg Asp Lys Leu Thr Gln Met Leu Lys 
                245                 250                 255     


Cys His Val Phe Arg Cys Glu Ala Pro Ala Lys Asn Ile Ala Thr Ser 
            260                 265                 270         


Leu His Glu Ile Cys Ser Lys Ile Met Ala Glu Arg Arg Asn Ala Arg 
        275                 280                 285             


Cys Leu Val Asn Gly Leu Ser Leu Asp His Ser Lys Leu Val Asp Val 
    290                 295                 300                 


Pro Phe Gln Val Glu Phe Pro Ala Pro Lys Asn Glu Leu Val Gln Lys 
305                 310                 315                 320 


Phe Gln Val Tyr Tyr Leu Gly Asn Val Pro Val Ala Lys Pro Val Gly 
                325                 330                 335     


Val Asp Val Ile Asn Gly Ala Leu Glu Ser Val Leu Ser Ser Ser Ser 
            340                 345                 350         


Arg Glu Gln Trp Thr Pro Ser His Val Ser Val Ala Pro Ala Thr Leu 
        355                 360                 365             


Thr Ile Leu His Gln Gln Thr Glu Ala Val Leu Gly Glu Cys Arg Val 
    370                 375                 380                 


Arg Phe Leu Ser Phe Leu Ala Val Gly Arg Asp Val His Thr Phe Ala 
385                 390                 395                 400 


Phe Ile Met Ala Ala Gly Pro Ala Ser Phe Cys Cys His Met Phe Trp 
                405                 410                 415     


Cys Glu Pro Asn Ala Ala Ser Leu Ser Glu Ala Val Gln Ala Ala Cys 
            420                 425                 430         


Met Leu Arg Tyr Gln Lys Cys Leu Asp Ala Arg Ser Gln Ala Ser Thr 
        435                 440                 445             


Ser Cys Leu Pro Ala Pro Pro Ala Glu Ser Val Ala Arg Arg Val Gly 
    450                 455                 460                 


Trp Thr Val Arg Arg Gly Val Gln Ser Leu Trp Gly Ser Leu Lys Pro 
465                 470                 475                 480 


Lys Arg Leu Gly Ala His Thr Pro 
                485             


<210>  900
<211>  490
<212>  PRT
<213>  Homo Sapiens

<400>  900

Met Ser Ala Met Phe Ser Gln Asp Phe Phe Leu Ala Ile Ile Leu Gln 
1               5                   10                  15      


Asp Ser Ser Ala Asp Ser Phe Trp Asn Pro Asn Ala Phe Glu Thr Asp 
            20                  25                  30          


Ser Asp Leu Pro Ala Gly Trp Met Arg Val Gln Asp Thr Ser Gly Thr 
        35                  40                  45              


Tyr Tyr Trp His Ile Pro Thr Gly Thr Thr Gln Trp Glu Pro Pro Gly 
    50                  55                  60                  


Arg Ala Ser Pro Ser Gln Gly Ser Ser Pro Gln Glu Glu Ser Gln Leu 
65                  70                  75                  80  


Thr Trp Thr Gly Phe Ala His Gly Glu Gly Phe Glu Asp Gly Glu Phe 
                85                  90                  95      


Trp Lys Asp Glu Pro Ser Asp Glu Ala Pro Met Glu Leu Gly Leu Lys 
            100                 105                 110         


Glu Pro Glu Glu Gly Thr Leu Thr Phe Pro Ala Gln Ser Leu Ser Pro 
        115                 120                 125             


Glu Pro Leu Pro Gln Glu Glu Glu Lys Leu Pro Pro Arg Asn Thr Asn 
    130                 135                 140                 


Pro Gly Ile Lys Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu Met 
145                 150                 155                 160 


Thr Glu Glu Glu Leu Ala Pro Gly Arg Ser Ser Val Ala Val Asn Asn 
                165                 170                 175     


Cys Ile Arg Gln Leu Ser Tyr His Lys Asn Asn Leu His Asp Pro Met 
            180                 185                 190         


Ser Gly Gly Trp Gly Glu Gly Lys Asp Leu Leu Leu Gln Leu Glu Asp 
        195                 200                 205             


Glu Thr Leu Lys Leu Val Glu Pro Gln Ser Gln Ala Leu Leu His Ala 
    210                 215                 220                 


Gln Pro Ile Ile Ser Ile Arg Val Trp Gly Val Gly Arg Asp Ser Gly 
225                 230                 235                 240 


Arg Glu Arg Asp Phe Ala Tyr Val Ala Arg Asp Lys Leu Thr Gln Met 
                245                 250                 255     


Leu Lys Cys His Val Phe Arg Cys Glu Ala Pro Ala Lys Asn Ile Ala 
            260                 265                 270         


Thr Ser Leu His Glu Ile Cys Ser Lys Ile Met Ala Glu Arg Arg Asn 
        275                 280                 285             


Ala Arg Cys Leu Val Asn Gly Leu Ser Leu Asp His Ser Lys Leu Val 
    290                 295                 300                 


Asp Val Pro Phe Gln Val Glu Phe Pro Ala Pro Lys Asn Glu Leu Val 
305                 310                 315                 320 


Gln Lys Phe Gln Val Tyr Tyr Leu Gly Asn Val Pro Val Ala Lys Pro 
                325                 330                 335     


Val Gly Val Asp Val Ile Asn Gly Ala Leu Glu Ser Val Leu Ser Ser 
            340                 345                 350         


Ser Ser Arg Glu Gln Trp Thr Pro Ser His Val Ser Val Ala Pro Ala 
        355                 360                 365             


Thr Leu Thr Ile Leu His Gln Gln Thr Glu Ala Val Leu Gly Glu Cys 
    370                 375                 380                 


Arg Val Arg Phe Leu Ser Phe Leu Ala Val Gly Arg Asp Val His Thr 
385                 390                 395                 400 


Phe Ala Phe Ile Met Ala Ala Gly Pro Ala Ser Phe Cys Cys His Met 
                405                 410                 415     


Phe Trp Cys Glu Pro Asn Ala Ala Ser Leu Ser Glu Ala Val Gln Ala 
            420                 425                 430         


Ala Cys Met Leu Arg Tyr Gln Lys Cys Leu Asp Ala Arg Ser Gln Ala 
        435                 440                 445             


Ser Thr Ser Cys Leu Pro Ala Pro Pro Ala Glu Ser Val Ala Arg Arg 
    450                 455                 460                 


Val Gly Trp Thr Val Arg Arg Gly Val Gln Ser Leu Trp Gly Ser Leu 
465                 470                 475                 480 


Lys Pro Lys Arg Leu Gly Ala His Thr Pro 
                485                 490 


<210>  901
<211>  708
<212>  PRT
<213>  Homo Sapiens

<400>  901

Met Ser Val Pro Ser Ser Leu Ser Gln Ser Ala Ile Asn Ala Asn Ser 
1               5                   10                  15      


His Gly Gly Pro Ala Leu Ser Leu Pro Leu Pro Leu His Ala Ala His 
            20                  25                  30          


Asn Gln Leu Leu Asn Ala Lys Leu Gln Ala Thr Ala Val Gly Pro Lys 
        35                  40                  45              


Asp Leu Arg Ser Ala Met Gly Glu Gly Gly Gly Pro Glu Pro Gly Pro 
    50                  55                  60                  


Ala Asn Ala Lys Trp Leu Lys Glu Gly Gln Asn Gln Leu Arg Arg Ala 
65                  70                  75                  80  


Ala Thr Ala His Arg Asp Gln Asn Arg Asn Val Thr Leu Thr Leu Ala 
                85                  90                  95      


Glu Glu Ala Ser Gln Glu Pro Glu Met Ala Pro Leu Gly Pro Lys Gly 
            100                 105                 110         


Leu Ile His Leu Tyr Ser Glu Leu Glu Leu Ser Ala His Asn Ala Ala 
        115                 120                 125             


Asn Arg Gly Leu Arg Gly Pro Gly Leu Ile Ile Ser Thr Gln Glu Gln 
    130                 135                 140                 


Gly Pro Asp Glu Gly Glu Glu Lys Ala Ala Gly Glu Ala Glu Glu Glu 
145                 150                 155                 160 


Glu Glu Asp Asp Asp Asp Glu Glu Glu Glu Glu Asp Leu Ser Ser Pro 
                165                 170                 175     


Pro Gly Leu Pro Glu Pro Leu Glu Ser Val Glu Ala Pro Pro Arg Pro 
            180                 185                 190         


Gln Ala Leu Thr Asp Gly Pro Arg Glu His Ser Lys Ser Ala Ser Leu 
        195                 200                 205             


Leu Phe Gly Met Arg Asn Ser Ala Ala Ser Asp Glu Asp Ser Ser Trp 
    210                 215                 220                 


Ala Thr Leu Ser Gln Gly Ser Pro Ser Tyr Gly Ser Pro Glu Asp Thr 
225                 230                 235                 240 


Asp Ser Phe Trp Asn Pro Asn Ala Phe Glu Thr Asp Ser Asp Leu Pro 
                245                 250                 255     


Ala Gly Trp Met Arg Val Gln Asp Thr Ser Gly Thr Tyr Tyr Trp His 
            260                 265                 270         


Ile Pro Thr Gly Thr Thr Gln Trp Glu Pro Pro Gly Arg Ala Ser Pro 
        275                 280                 285             


Ser Gln Gly Ser Ser Pro Gln Glu Glu Ser Gln Leu Thr Trp Thr Gly 
    290                 295                 300                 


Phe Ala His Gly Glu Gly Phe Glu Asp Gly Glu Phe Trp Lys Asp Glu 
305                 310                 315                 320 


Pro Ser Asp Glu Ala Pro Met Glu Leu Gly Leu Lys Glu Pro Glu Glu 
                325                 330                 335     


Gly Thr Leu Thr Phe Pro Ala Gln Ser Leu Ser Pro Glu Pro Leu Pro 
            340                 345                 350         


Gln Glu Glu Glu Lys Leu Pro Pro Arg Asn Thr Asn Pro Gly Ile Lys 
        355                 360                 365             


Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu Met Thr Glu Glu Glu 
    370                 375                 380                 


Leu Ala Pro Gly Arg Ser Ser Val Ala Val Asn Asn Cys Ile Arg Gln 
385                 390                 395                 400 


Leu Ser Tyr His Lys Asn Asn Leu His Asp Pro Met Ser Gly Gly Trp 
                405                 410                 415     


Gly Glu Gly Lys Asp Leu Leu Leu Gln Leu Glu Asp Glu Thr Leu Lys 
            420                 425                 430         


Leu Val Glu Pro Gln Ser Gln Ala Leu Leu His Ala Gln Pro Ile Ile 
        435                 440                 445             


Ser Ile Arg Val Trp Gly Val Gly Arg Asp Ser Gly Arg Asp Phe Ala 
    450                 455                 460                 


Tyr Val Ala Arg Asp Lys Leu Thr Gln Met Leu Lys Cys His Val Phe 
465                 470                 475                 480 


Arg Cys Glu Ala Pro Ala Lys Asn Ile Ala Thr Ser Leu His Glu Ile 
                485                 490                 495     


Cys Ser Lys Ile Met Ala Glu Arg Arg Asn Ala Arg Cys Leu Val Asn 
            500                 505                 510         


Gly Leu Ser Leu Asp His Ser Lys Leu Val Asp Val Pro Phe Gln Val 
        515                 520                 525             


Glu Phe Pro Ala Pro Lys Asn Glu Leu Val Gln Lys Phe Gln Val Tyr 
    530                 535                 540                 


Tyr Leu Gly Asn Val Pro Val Ala Lys Pro Val Gly Val Asp Val Ile 
545                 550                 555                 560 


Asn Gly Ala Leu Glu Ser Val Leu Ser Ser Ser Ser Arg Glu Gln Trp 
                565                 570                 575     


Thr Pro Ser His Val Ser Val Ala Pro Ala Thr Leu Thr Ile Leu His 
            580                 585                 590         


Gln Gln Thr Glu Ala Val Leu Gly Glu Cys Arg Val Arg Phe Leu Ser 
        595                 600                 605             


Phe Leu Ala Val Gly Arg Asp Val His Thr Phe Ala Phe Ile Met Ala 
    610                 615                 620                 


Ala Gly Pro Ala Ser Phe Cys Cys His Met Phe Trp Cys Glu Pro Asn 
625                 630                 635                 640 


Ala Ala Ser Leu Ser Glu Ala Val Gln Ala Ala Cys Met Leu Arg Tyr 
                645                 650                 655     


Gln Lys Cys Leu Asp Ala Arg Ser Gln Ala Ser Thr Ser Cys Leu Pro 
            660                 665                 670         


Ala Pro Pro Ala Glu Ser Val Ala Arg Arg Val Gly Trp Thr Val Arg 
        675                 680                 685             


Arg Gly Val Gln Ser Leu Trp Gly Ser Leu Lys Pro Lys Arg Leu Gly 
    690                 695                 700                 


Ala His Thr Pro 
705             


<210>  902
<211>  708
<212>  PRT
<213>  Homo Sapiens

<400>  902

Met Ser Val Pro Ser Ser Leu Ser Gln Ser Ala Ile Asn Ala Asn Ser 
1               5                   10                  15      


His Gly Gly Pro Ala Leu Ser Leu Pro Leu Pro Leu His Ala Ala His 
            20                  25                  30          


Asn Gln Leu Leu Asn Ala Lys Leu Gln Ala Thr Ala Val Gly Pro Lys 
        35                  40                  45              


Asp Leu Arg Ser Ala Met Gly Glu Gly Gly Gly Pro Glu Pro Gly Pro 
    50                  55                  60                  


Ala Asn Ala Lys Trp Leu Lys Glu Gly Gln Asn Gln Leu Arg Arg Ala 
65                  70                  75                  80  


Ala Thr Ala His Arg Asp Gln Asn Arg Asn Val Thr Leu Thr Leu Ala 
                85                  90                  95      


Glu Glu Ala Ser Gln Glu Pro Glu Met Ala Pro Leu Gly Pro Lys Gly 
            100                 105                 110         


Leu Ile His Leu Tyr Ser Glu Leu Glu Leu Ser Ala His Asn Ala Ala 
        115                 120                 125             


Asn Arg Gly Leu Arg Gly Pro Gly Leu Ile Ile Ser Thr Gln Glu Gln 
    130                 135                 140                 


Gly Pro Asp Glu Gly Glu Glu Lys Ala Ala Gly Glu Ala Glu Glu Glu 
145                 150                 155                 160 


Glu Glu Asp Asp Asp Asp Glu Glu Glu Glu Glu Asp Leu Ser Ser Pro 
                165                 170                 175     


Pro Gly Leu Pro Glu Pro Leu Glu Ser Val Glu Ala Pro Pro Arg Pro 
            180                 185                 190         


Gln Ala Leu Thr Asp Gly Pro Arg Glu His Ser Lys Ser Ala Ser Leu 
        195                 200                 205             


Leu Phe Gly Met Arg Asn Ser Ala Ala Ser Asp Glu Asp Ser Ser Trp 
    210                 215                 220                 


Ala Thr Leu Ser Gln Gly Ser Pro Ser Tyr Gly Ser Pro Glu Asp Thr 
225                 230                 235                 240 


Asp Ser Phe Trp Asn Pro Asn Ala Phe Glu Thr Asp Ser Asp Leu Pro 
                245                 250                 255     


Ala Gly Trp Met Arg Val Gln Asp Thr Ser Gly Thr Tyr Tyr Trp His 
            260                 265                 270         


Ile Pro Thr Gly Thr Thr Gln Trp Glu Pro Pro Gly Arg Ala Ser Pro 
        275                 280                 285             


Ser Gln Gly Ser Ser Pro Gln Glu Glu Ser Gln Leu Thr Trp Thr Gly 
    290                 295                 300                 


Phe Ala His Gly Glu Gly Phe Glu Asp Gly Glu Phe Trp Lys Asp Glu 
305                 310                 315                 320 


Pro Ser Asp Glu Ala Pro Met Glu Leu Gly Leu Lys Glu Pro Glu Glu 
                325                 330                 335     


Gly Thr Leu Thr Phe Pro Ala Gln Ser Leu Ser Pro Glu Pro Leu Pro 
            340                 345                 350         


Gln Glu Glu Glu Lys Leu Pro Pro Arg Asn Thr Asn Pro Gly Ile Lys 
        355                 360                 365             


Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu Met Thr Glu Glu Glu 
    370                 375                 380                 


Leu Ala Pro Gly Arg Ser Ser Val Ala Val Asn Asn Cys Ile Arg Gln 
385                 390                 395                 400 


Leu Ser Tyr His Lys Asn Asn Leu His Asp Pro Met Ser Gly Gly Trp 
                405                 410                 415     


Gly Glu Gly Lys Asp Leu Leu Leu Gln Leu Glu Asp Glu Thr Leu Lys 
            420                 425                 430         


Leu Val Glu Pro Gln Ser Gln Ala Leu Leu His Ala Gln Pro Ile Ile 
        435                 440                 445             


Ser Ile Arg Val Trp Gly Val Gly Arg Asp Ser Gly Arg Asp Phe Ala 
    450                 455                 460                 


Tyr Val Ala Arg Asp Lys Leu Thr Gln Met Leu Lys Cys His Val Phe 
465                 470                 475                 480 


Arg Cys Glu Ala Pro Ala Lys Asn Ile Ala Thr Ser Leu His Glu Ile 
                485                 490                 495     


Cys Ser Lys Ile Met Ala Glu Arg Arg Asn Ala Arg Cys Leu Val Asn 
            500                 505                 510         


Gly Leu Ser Leu Asp His Ser Lys Leu Val Asp Val Pro Phe Gln Val 
        515                 520                 525             


Glu Phe Pro Ala Pro Lys Asn Glu Leu Val Gln Lys Phe Gln Val Tyr 
    530                 535                 540                 


Tyr Leu Gly Asn Val Pro Val Ala Lys Pro Val Gly Val Asp Val Ile 
545                 550                 555                 560 


Asn Gly Ala Leu Glu Ser Val Leu Ser Ser Ser Ser Arg Glu Gln Trp 
                565                 570                 575     


Thr Pro Ser His Val Ser Val Ala Pro Ala Thr Leu Thr Ile Leu His 
            580                 585                 590         


Gln Gln Thr Glu Ala Val Leu Gly Glu Cys Arg Val Arg Phe Leu Ser 
        595                 600                 605             


Phe Leu Ala Val Gly Arg Asp Val His Thr Phe Ala Phe Ile Met Ala 
    610                 615                 620                 


Ala Gly Pro Ala Ser Phe Cys Cys His Met Phe Trp Cys Glu Pro Asn 
625                 630                 635                 640 


Ala Ala Ser Leu Ser Glu Ala Val Gln Ala Ala Cys Met Leu Arg Tyr 
                645                 650                 655     


Gln Lys Cys Leu Asp Ala Arg Ser Gln Ala Ser Thr Ser Cys Leu Pro 
            660                 665                 670         


Ala Pro Pro Ala Glu Ser Val Ala Arg Arg Val Gly Trp Thr Val Arg 
        675                 680                 685             


Arg Gly Val Gln Ser Leu Trp Gly Ser Leu Lys Pro Lys Arg Leu Gly 
    690                 695                 700                 


Ala His Thr Pro 
705             


<210>  903
<211>  710
<212>  PRT
<213>  Homo Sapiens

<400>  903

Met Ser Val Pro Ser Ser Leu Ser Gln Ser Ala Ile Asn Ala Asn Ser 
1               5                   10                  15      


His Gly Gly Pro Ala Leu Ser Leu Pro Leu Pro Leu His Ala Ala His 
            20                  25                  30          


Asn Gln Leu Leu Asn Ala Lys Leu Gln Ala Thr Ala Val Gly Pro Lys 
        35                  40                  45              


Asp Leu Arg Ser Ala Met Gly Glu Gly Gly Gly Pro Glu Pro Gly Pro 
    50                  55                  60                  


Ala Asn Ala Lys Trp Leu Lys Glu Gly Gln Asn Gln Leu Arg Arg Ala 
65                  70                  75                  80  


Ala Thr Ala His Arg Asp Gln Asn Arg Asn Val Thr Leu Thr Leu Ala 
                85                  90                  95      


Glu Glu Ala Ser Gln Glu Pro Glu Met Ala Pro Leu Gly Pro Lys Gly 
            100                 105                 110         


Leu Ile His Leu Tyr Ser Glu Leu Glu Leu Ser Ala His Asn Ala Ala 
        115                 120                 125             


Asn Arg Gly Leu Arg Gly Pro Gly Leu Ile Ile Ser Thr Gln Glu Gln 
    130                 135                 140                 


Gly Pro Asp Glu Gly Glu Glu Lys Ala Ala Gly Glu Ala Glu Glu Glu 
145                 150                 155                 160 


Glu Glu Asp Asp Asp Asp Glu Glu Glu Glu Glu Asp Leu Ser Ser Pro 
                165                 170                 175     


Pro Gly Leu Pro Glu Pro Leu Glu Ser Val Glu Ala Pro Pro Arg Pro 
            180                 185                 190         


Gln Ala Leu Thr Asp Gly Pro Arg Glu His Ser Lys Ser Ala Ser Leu 
        195                 200                 205             


Leu Phe Gly Met Arg Asn Ser Ala Ala Ser Asp Glu Asp Ser Ser Trp 
    210                 215                 220                 


Ala Thr Leu Ser Gln Gly Ser Pro Ser Tyr Gly Ser Pro Glu Asp Thr 
225                 230                 235                 240 


Asp Ser Phe Trp Asn Pro Asn Ala Phe Glu Thr Asp Ser Asp Leu Pro 
                245                 250                 255     


Ala Gly Trp Met Arg Val Gln Asp Thr Ser Gly Thr Tyr Tyr Trp His 
            260                 265                 270         


Ile Pro Thr Gly Thr Thr Gln Trp Glu Pro Pro Gly Arg Ala Ser Pro 
        275                 280                 285             


Ser Gln Gly Ser Ser Pro Gln Glu Glu Ser Gln Leu Thr Trp Thr Gly 
    290                 295                 300                 


Phe Ala His Gly Glu Gly Phe Glu Asp Gly Glu Phe Trp Lys Asp Glu 
305                 310                 315                 320 


Pro Ser Asp Glu Ala Pro Met Glu Leu Gly Leu Lys Glu Pro Glu Glu 
                325                 330                 335     


Gly Thr Leu Thr Phe Pro Ala Gln Ser Leu Ser Pro Glu Pro Leu Pro 
            340                 345                 350         


Gln Glu Glu Glu Lys Leu Pro Pro Arg Asn Thr Asn Pro Gly Ile Lys 
        355                 360                 365             


Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu Met Thr Glu Glu Glu 
    370                 375                 380                 


Leu Ala Pro Gly Arg Ser Ser Val Ala Val Asn Asn Cys Ile Arg Gln 
385                 390                 395                 400 


Leu Ser Tyr His Lys Asn Asn Leu His Asp Pro Met Ser Gly Gly Trp 
                405                 410                 415     


Gly Glu Gly Lys Asp Leu Leu Leu Gln Leu Glu Asp Glu Thr Leu Lys 
            420                 425                 430         


Leu Val Glu Pro Gln Ser Gln Ala Leu Leu His Ala Gln Pro Ile Ile 
        435                 440                 445             


Ser Ile Arg Val Trp Gly Val Gly Arg Asp Ser Gly Ser Asn Arg Asp 
    450                 455                 460                 


Phe Ala Tyr Val Ala Arg Asp Lys Leu Thr Gln Met Leu Lys Cys His 
465                 470                 475                 480 


Val Phe Arg Cys Glu Ala Pro Ala Lys Asn Ile Ala Thr Ser Leu His 
                485                 490                 495     


Glu Ile Cys Ser Lys Ile Met Ala Glu Arg Arg Asn Ala Arg Cys Leu 
            500                 505                 510         


Val Asn Gly Leu Ser Leu Asp His Ser Lys Leu Val Asp Val Pro Phe 
        515                 520                 525             


Gln Val Glu Phe Pro Ala Pro Lys Asn Glu Leu Val Gln Lys Phe Gln 
    530                 535                 540                 


Val Tyr Tyr Leu Gly Asn Val Pro Val Ala Lys Pro Val Gly Val Asp 
545                 550                 555                 560 


Val Ile Asn Gly Ala Leu Glu Ser Val Leu Ser Ser Ser Ser Arg Glu 
                565                 570                 575     


Gln Trp Thr Pro Ser His Val Ser Val Ala Pro Ala Thr Leu Thr Ile 
            580                 585                 590         


Leu His Gln Gln Thr Glu Ala Val Leu Gly Glu Cys Arg Val Arg Phe 
        595                 600                 605             


Leu Ser Phe Leu Ala Val Gly Arg Asp Val His Thr Phe Ala Phe Ile 
    610                 615                 620                 


Met Ala Ala Gly Pro Ala Ser Phe Cys Cys His Met Phe Trp Cys Glu 
625                 630                 635                 640 


Pro Asn Ala Ala Ser Leu Ser Glu Ala Val Gln Ala Ala Cys Met Leu 
                645                 650                 655     


Arg Tyr Gln Lys Cys Leu Asp Ala Arg Ser Gln Ala Ser Thr Ser Cys 
            660                 665                 670         


Leu Pro Ala Pro Pro Ala Glu Ser Val Ala Arg Arg Val Gly Trp Thr 
        675                 680                 685             


Val Arg Arg Gly Val Gln Ser Leu Trp Gly Ser Leu Lys Pro Lys Arg 
    690                 695                 700                 


Leu Gly Ala His Thr Pro 
705                 710 


<210>  904
<211>  710
<212>  PRT
<213>  Homo Sapiens

<400>  904

Met Ser Val Pro Ser Ser Leu Ser Gln Ser Ala Ile Asn Ala Asn Ser 
1               5                   10                  15      


His Gly Gly Pro Ala Leu Ser Leu Pro Leu Pro Leu His Ala Ala His 
            20                  25                  30          


Asn Gln Leu Leu Asn Ala Lys Leu Gln Ala Thr Ala Val Gly Pro Lys 
        35                  40                  45              


Asp Leu Arg Ser Ala Met Gly Glu Gly Gly Gly Pro Glu Pro Gly Pro 
    50                  55                  60                  


Ala Asn Ala Lys Trp Leu Lys Glu Gly Gln Asn Gln Leu Arg Arg Ala 
65                  70                  75                  80  


Ala Thr Ala His Arg Asp Gln Asn Arg Asn Val Thr Leu Thr Leu Ala 
                85                  90                  95      


Glu Glu Ala Ser Gln Glu Pro Glu Met Ala Pro Leu Gly Pro Lys Gly 
            100                 105                 110         


Leu Ile His Leu Tyr Ser Glu Leu Glu Leu Ser Ala His Asn Ala Ala 
        115                 120                 125             


Asn Arg Gly Leu Arg Gly Pro Gly Leu Ile Ile Ser Thr Gln Glu Gln 
    130                 135                 140                 


Gly Pro Asp Glu Gly Glu Glu Lys Ala Ala Gly Glu Ala Glu Glu Glu 
145                 150                 155                 160 


Glu Glu Asp Asp Asp Asp Glu Glu Glu Glu Glu Asp Leu Ser Ser Pro 
                165                 170                 175     


Pro Gly Leu Pro Glu Pro Leu Glu Ser Val Glu Ala Pro Pro Arg Pro 
            180                 185                 190         


Gln Ala Leu Thr Asp Gly Pro Arg Glu His Ser Lys Ser Ala Ser Leu 
        195                 200                 205             


Leu Phe Gly Met Arg Asn Ser Ala Ala Ser Asp Glu Asp Ser Ser Trp 
    210                 215                 220                 


Ala Thr Leu Ser Gln Gly Ser Pro Ser Tyr Gly Ser Pro Glu Asp Thr 
225                 230                 235                 240 


Asp Ser Phe Trp Asn Pro Asn Ala Phe Glu Thr Asp Ser Asp Leu Pro 
                245                 250                 255     


Ala Gly Trp Met Arg Val Gln Asp Thr Ser Gly Thr Tyr Tyr Trp His 
            260                 265                 270         


Ile Pro Thr Gly Thr Thr Gln Trp Glu Pro Pro Gly Arg Ala Ser Pro 
        275                 280                 285             


Ser Gln Gly Ser Ser Pro Gln Glu Glu Ser Gln Leu Thr Trp Thr Gly 
    290                 295                 300                 


Phe Ala His Gly Glu Gly Phe Glu Asp Gly Glu Phe Trp Lys Asp Glu 
305                 310                 315                 320 


Pro Ser Asp Glu Ala Pro Met Glu Leu Gly Leu Lys Glu Pro Glu Glu 
                325                 330                 335     


Gly Thr Leu Thr Phe Pro Ala Gln Ser Leu Ser Pro Glu Pro Leu Pro 
            340                 345                 350         


Gln Glu Glu Glu Lys Leu Pro Pro Arg Asn Thr Asn Pro Gly Ile Lys 
        355                 360                 365             


Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu Met Thr Glu Glu Glu 
    370                 375                 380                 


Leu Ala Pro Gly Arg Ser Ser Val Ala Val Asn Asn Cys Ile Arg Gln 
385                 390                 395                 400 


Leu Ser Tyr His Lys Asn Asn Leu His Asp Pro Met Ser Gly Gly Trp 
                405                 410                 415     


Gly Glu Gly Lys Asp Leu Leu Leu Gln Leu Glu Asp Glu Thr Leu Lys 
            420                 425                 430         


Leu Val Glu Pro Gln Ser Gln Ala Leu Leu His Ala Gln Pro Ile Ile 
        435                 440                 445             


Ser Ile Arg Val Trp Gly Val Gly Arg Asp Ser Gly Arg Glu Arg Asp 
    450                 455                 460                 


Phe Ala Tyr Val Ala Arg Asp Lys Leu Thr Gln Met Leu Lys Cys His 
465                 470                 475                 480 


Val Phe Arg Cys Glu Ala Pro Ala Lys Asn Ile Ala Thr Ser Leu His 
                485                 490                 495     


Glu Ile Cys Ser Lys Ile Met Ala Glu Arg Arg Asn Ala Arg Cys Leu 
            500                 505                 510         


Val Asn Gly Leu Ser Leu Asp His Ser Lys Leu Val Asp Val Pro Phe 
        515                 520                 525             


Gln Val Glu Phe Pro Ala Pro Lys Asn Glu Leu Val Gln Lys Phe Gln 
    530                 535                 540                 


Val Tyr Tyr Leu Gly Asn Val Pro Val Ala Lys Pro Val Gly Val Asp 
545                 550                 555                 560 


Val Ile Asn Gly Ala Leu Glu Ser Val Leu Ser Ser Ser Ser Arg Glu 
                565                 570                 575     


Gln Trp Thr Pro Ser His Val Ser Val Ala Pro Ala Thr Leu Thr Ile 
            580                 585                 590         


Leu His Gln Gln Thr Glu Ala Val Leu Gly Glu Cys Arg Val Arg Phe 
        595                 600                 605             


Leu Ser Phe Leu Ala Val Gly Arg Asp Val His Thr Phe Ala Phe Ile 
    610                 615                 620                 


Met Ala Ala Gly Pro Ala Ser Phe Cys Cys His Met Phe Trp Cys Glu 
625                 630                 635                 640 


Pro Asn Ala Ala Ser Leu Ser Glu Ala Val Gln Ala Ala Cys Met Leu 
                645                 650                 655     


Arg Tyr Gln Lys Cys Leu Asp Ala Arg Ser Gln Ala Ser Thr Ser Cys 
            660                 665                 670         


Leu Pro Ala Pro Pro Ala Glu Ser Val Ala Arg Arg Val Gly Trp Thr 
        675                 680                 685             


Val Arg Arg Gly Val Gln Ser Leu Trp Gly Ser Leu Lys Pro Lys Arg 
    690                 695                 700                 


Leu Gly Ala His Thr Pro 
705                 710 


<210>  905
<211>  707
<212>  PRT
<213>  Homo Sapiens

<400>  905

Met Ser Val Pro Ser Ser Leu Ser Gln Ser Ala Ile Asn Ala Asn Ser 
1               5                   10                  15      


His Gly Gly Pro Ala Leu Ser Leu Pro Leu Pro Leu His Ala Ala His 
            20                  25                  30          


Asn Gln Leu Leu Asn Ala Lys Leu Gln Ala Thr Ala Val Gly Pro Lys 
        35                  40                  45              


Asp Leu Arg Ser Ala Met Gly Glu Gly Gly Gly Pro Glu Pro Gly Pro 
    50                  55                  60                  


Ala Asn Ala Lys Trp Leu Lys Glu Gly Gln Asn Gln Leu Arg Arg Ala 
65                  70                  75                  80  


Ala Thr Ala His Arg Asp Gln Asn Arg Asn Val Thr Leu Thr Leu Ala 
                85                  90                  95      


Glu Glu Ala Ser Gln Glu Pro Glu Met Ala Pro Leu Gly Pro Lys Gly 
            100                 105                 110         


Leu Ile His Leu Tyr Ser Glu Leu Glu Leu Ser Ala His Asn Ala Ala 
        115                 120                 125             


Asn Arg Gly Leu Arg Gly Pro Gly Leu Ile Ile Ser Thr Gln Glu Gln 
    130                 135                 140                 


Gly Pro Asp Glu Gly Glu Glu Lys Ala Ala Gly Glu Ala Glu Glu Glu 
145                 150                 155                 160 


Glu Glu Asp Asp Asp Asp Glu Glu Glu Glu Glu Asp Leu Ser Ser Pro 
                165                 170                 175     


Pro Gly Leu Pro Glu Pro Leu Glu Ser Val Glu Ala Pro Pro Arg Pro 
            180                 185                 190         


Gln Ala Leu Thr Asp Gly Pro Arg Glu His Ser Lys Ser Ala Ser Leu 
        195                 200                 205             


Leu Phe Gly Met Arg Asn Ser Ala Ala Ser Asp Glu Asp Ser Ser Trp 
    210                 215                 220                 


Ala Thr Leu Ser Gln Gly Ser Pro Ser Tyr Gly Ser Pro Glu Asp Thr 
225                 230                 235                 240 


Asp Ser Phe Trp Asn Pro Asn Ala Phe Glu Thr Asp Ser Asp Leu Pro 
                245                 250                 255     


Ala Gly Trp Met Arg Val Gln Asp Thr Ser Gly Thr Tyr Tyr Trp His 
            260                 265                 270         


Ile Pro Thr Gly Thr Thr Gln Trp Glu Pro Pro Gly Arg Ala Ser Pro 
        275                 280                 285             


Ser Gln Gly Ser Ser Pro Gln Glu Glu Ser Gln Leu Thr Trp Thr Gly 
    290                 295                 300                 


Phe Ala His Gly Glu Gly Phe Glu Asp Gly Glu Phe Trp Lys Asp Glu 
305                 310                 315                 320 


Pro Ser Asp Glu Ala Pro Met Glu Leu Gly Leu Lys Glu Pro Glu Glu 
                325                 330                 335     


Gly Thr Leu Thr Phe Pro Ala Gln Ser Leu Ser Pro Glu Pro Leu Pro 
            340                 345                 350         


Gln Glu Glu Glu Lys Leu Pro Pro Arg Asn Thr Asn Pro Gly Ile Lys 
        355                 360                 365             


Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu Met Thr Glu Glu Glu 
    370                 375                 380                 


Leu Ala Pro Gly Arg Ser Ser Val Ala Val Asn Asn Cys Ile Arg Gln 
385                 390                 395                 400 


Leu Ser Tyr His Lys Asn Asn Leu His Asp Pro Met Ser Gly Gly Trp 
                405                 410                 415     


Gly Glu Gly Lys Asp Leu Leu Leu Gln Leu Glu Asp Glu Thr Leu Lys 
            420                 425                 430         


Leu Val Glu Pro Gln Ser Gln Ala Leu Leu His Ala Gln Pro Ile Ile 
        435                 440                 445             


Ser Ile Arg Val Trp Gly Val Gly Arg Asp Ser Gly Arg Glu Arg Asp 
    450                 455                 460                 


Phe Ala Tyr Val Ala Arg Asp Lys Leu Thr Gln Met Leu Lys Cys His 
465                 470                 475                 480 


Val Phe Arg Cys Glu Ala Pro Ala Lys Asn Ile Ala Thr Ser Leu His 
                485                 490                 495     


Glu Ile Cys Ser Lys Ile Met Ala Glu Arg Arg Asn Ala Arg Cys Leu 
            500                 505                 510         


Val Asn Gly Leu Ser Leu Asp His Ser Lys Leu Val Asp Val Pro Phe 
        515                 520                 525             


Gln Val Glu Phe Pro Ala Pro Lys Asn Glu Leu Val Gln Lys Phe Gln 
    530                 535                 540                 


Val Tyr Tyr Leu Gly Asn Val Pro Val Ala Lys Pro Val Gly Val Asp 
545                 550                 555                 560 


Val Ile Asn Gly Ala Leu Glu Ser Val Leu Ser Ser Ser Ser Arg Glu 
                565                 570                 575     


Gln Trp Thr Pro Ser His Val Ser Val Ala Pro Ala Thr Leu Thr Ile 
            580                 585                 590         


Leu His Gln Gln Thr Glu Ala Val Leu Gly Glu Cys Arg Val Arg Phe 
        595                 600                 605             


Leu Ser Phe Leu Ala Val Gly Arg Asp Val His Thr Phe Ala Phe Ile 
    610                 615                 620                 


Met Ala Ala Gly Pro Ala Ser Phe Cys Cys His Met Phe Trp Cys Glu 
625                 630                 635                 640 


Pro Asn Ala Ala Ser Leu Ser Glu Ala Val Gln Ala Ala Cys Met Val 
                645                 650                 655     


Glu Gln Glu Glu Leu Val Gln Ala Arg Pro His Pro Pro Gly Pro Ser 
            660                 665                 670         


Arg Gly Arg Arg Arg Lys Gly Leu Val Gln Ala Trp Val Pro Ser Pro 
        675                 680                 685             


Cys Ser Met Gly Thr Ser Ala Val Leu Ile Ser Leu Ile Lys Ser Val 
    690                 695                 700                 


Cys Thr Ala 
705         


<210>  906
<211>  475
<212>  PRT
<213>  Homo Sapiens

<400>  906

Met Thr Gln Met Arg Asp Ser Phe Trp Asn Pro Asn Ala Phe Glu Thr 
1               5                   10                  15      


Asp Ser Asp Leu Pro Ala Gly Trp Met Arg Val Gln Asp Thr Ser Gly 
            20                  25                  30          


Thr Tyr Tyr Trp His Ile Pro Thr Gly Thr Thr Gln Trp Glu Pro Pro 
        35                  40                  45              


Gly Arg Ala Ser Pro Ser Gln Gly Ser Ser Pro Gln Glu Glu Ser Gln 
    50                  55                  60                  


Leu Thr Trp Thr Gly Phe Ala His Gly Glu Gly Phe Glu Asp Gly Glu 
65                  70                  75                  80  


Phe Trp Lys Asp Glu Pro Ser Asp Glu Ala Pro Met Glu Leu Gly Leu 
                85                  90                  95      


Lys Glu Pro Glu Glu Gly Thr Leu Thr Phe Pro Ala Gln Ser Leu Ser 
            100                 105                 110         


Pro Glu Pro Leu Pro Gln Glu Glu Glu Lys Leu Pro Pro Arg Asn Thr 
        115                 120                 125             


Asn Pro Gly Ile Lys Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu 
    130                 135                 140                 


Met Thr Glu Glu Glu Leu Ala Pro Gly Arg Ser Ser Val Ala Val Asn 
145                 150                 155                 160 


Asn Cys Ile Arg Gln Leu Ser Tyr His Lys Asn Asn Leu His Asp Pro 
                165                 170                 175     


Met Ser Gly Gly Trp Gly Glu Gly Lys Asp Leu Leu Leu Gln Leu Glu 
            180                 185                 190         


Asp Glu Thr Leu Lys Leu Val Glu Pro Gln Ser Gln Ala Leu Leu His 
        195                 200                 205             


Ala Gln Pro Ile Ile Ser Ile Arg Val Trp Gly Val Gly Arg Asp Ser 
    210                 215                 220                 


Gly Arg Glu Arg Asp Phe Ala Tyr Val Ala Arg Asp Lys Leu Thr Gln 
225                 230                 235                 240 


Met Leu Lys Cys His Val Phe Arg Cys Glu Ala Pro Ala Lys Asn Ile 
                245                 250                 255     


Ala Thr Ser Leu His Glu Ile Cys Ser Lys Ile Met Ala Glu Arg Arg 
            260                 265                 270         


Asn Ala Arg Cys Leu Val Asn Gly Leu Ser Leu Asp His Ser Lys Leu 
        275                 280                 285             


Val Asp Val Pro Phe Gln Val Glu Phe Pro Ala Pro Lys Asn Glu Leu 
    290                 295                 300                 


Val Gln Lys Phe Gln Val Tyr Tyr Leu Gly Asn Val Pro Val Ala Lys 
305                 310                 315                 320 


Pro Val Gly Val Asp Val Ile Asn Gly Ala Leu Glu Ser Val Leu Ser 
                325                 330                 335     


Ser Ser Ser Arg Glu Gln Trp Thr Pro Ser His Val Ser Val Ala Pro 
            340                 345                 350         


Ala Thr Leu Thr Ile Leu His Gln Gln Thr Glu Ala Val Leu Gly Glu 
        355                 360                 365             


Cys Arg Val Arg Phe Leu Ser Phe Leu Ala Val Gly Arg Asp Val His 
    370                 375                 380                 


Thr Phe Ala Phe Ile Met Ala Ala Gly Pro Ala Ser Phe Cys Cys His 
385                 390                 395                 400 


Met Phe Trp Cys Glu Pro Asn Ala Ala Ser Leu Ser Glu Ala Val Gln 
                405                 410                 415     


Ala Ala Cys Met Leu Arg Tyr Gln Lys Cys Leu Asp Ala Arg Ser Gln 
            420                 425                 430         


Ala Ser Thr Ser Cys Leu Pro Ala Pro Pro Ala Glu Ser Val Ala Arg 
        435                 440                 445             


Arg Val Gly Trp Thr Val Arg Arg Gly Val Gln Ser Leu Trp Gly Ser 
    450                 455                 460                 


Leu Lys Pro Lys Arg Leu Gly Ala His Thr Pro 
465                 470                 475 


<210>  907
<211>  475
<212>  PRT
<213>  Homo Sapiens

<400>  907

Met Thr Gln Met Arg Asp Ser Phe Trp Asn Pro Asn Ala Phe Glu Thr 
1               5                   10                  15      


Asp Ser Asp Leu Pro Ala Gly Trp Met Arg Val Gln Asp Thr Ser Gly 
            20                  25                  30          


Thr Tyr Tyr Trp His Ile Pro Thr Gly Thr Thr Gln Trp Glu Pro Pro 
        35                  40                  45              


Gly Arg Ala Ser Pro Ser Gln Gly Ser Ser Pro Gln Glu Glu Ser Gln 
    50                  55                  60                  


Leu Thr Trp Thr Gly Phe Ala His Gly Glu Gly Phe Glu Asp Gly Glu 
65                  70                  75                  80  


Phe Trp Lys Asp Glu Pro Ser Asp Glu Ala Pro Met Glu Leu Gly Leu 
                85                  90                  95      


Lys Glu Pro Glu Glu Gly Thr Leu Thr Phe Pro Ala Gln Ser Leu Ser 
            100                 105                 110         


Pro Glu Pro Leu Pro Gln Glu Glu Glu Lys Leu Pro Pro Arg Asn Thr 
        115                 120                 125             


Asn Pro Gly Ile Lys Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu 
    130                 135                 140                 


Met Thr Glu Glu Glu Leu Ala Pro Gly Arg Ser Ser Val Ala Val Asn 
145                 150                 155                 160 


Asn Cys Ile Arg Gln Leu Ser Tyr His Lys Asn Asn Leu His Asp Pro 
                165                 170                 175     


Met Ser Gly Gly Trp Gly Glu Gly Lys Asp Leu Leu Leu Gln Leu Glu 
            180                 185                 190         


Asp Glu Thr Leu Lys Leu Val Glu Pro Gln Ser Gln Ala Leu Leu His 
        195                 200                 205             


Ala Gln Pro Ile Ile Ser Ile Arg Val Trp Gly Val Gly Arg Asp Ser 
    210                 215                 220                 


Gly Ser Asn Arg Asp Phe Ala Tyr Val Ala Arg Asp Lys Leu Thr Gln 
225                 230                 235                 240 


Met Leu Lys Cys His Val Phe Arg Cys Glu Ala Pro Ala Lys Asn Ile 
                245                 250                 255     


Ala Thr Ser Leu His Glu Ile Cys Ser Lys Ile Met Ala Glu Arg Arg 
            260                 265                 270         


Asn Ala Arg Cys Leu Val Asn Gly Leu Ser Leu Asp His Ser Lys Leu 
        275                 280                 285             


Val Asp Val Pro Phe Gln Val Glu Phe Pro Ala Pro Lys Asn Glu Leu 
    290                 295                 300                 


Val Gln Lys Phe Gln Val Tyr Tyr Leu Gly Asn Val Pro Val Ala Lys 
305                 310                 315                 320 


Pro Val Gly Val Asp Val Ile Asn Gly Ala Leu Glu Ser Val Leu Ser 
                325                 330                 335     


Ser Ser Ser Arg Glu Gln Trp Thr Pro Ser His Val Ser Val Ala Pro 
            340                 345                 350         


Ala Thr Leu Thr Ile Leu His Gln Gln Thr Glu Ala Val Leu Gly Glu 
        355                 360                 365             


Cys Arg Val Arg Phe Leu Ser Phe Leu Ala Val Gly Arg Asp Val His 
    370                 375                 380                 


Thr Phe Ala Phe Ile Met Ala Ala Gly Pro Ala Ser Phe Cys Cys His 
385                 390                 395                 400 


Met Phe Trp Cys Glu Pro Asn Ala Ala Ser Leu Ser Glu Ala Val Gln 
                405                 410                 415     


Ala Ala Cys Met Leu Arg Tyr Gln Lys Cys Leu Asp Ala Arg Ser Gln 
            420                 425                 430         


Ala Ser Thr Ser Cys Leu Pro Ala Pro Pro Ala Glu Ser Val Ala Arg 
        435                 440                 445             


Arg Val Gly Trp Thr Val Arg Arg Gly Val Gln Ser Leu Trp Gly Ser 
    450                 455                 460                 


Leu Lys Pro Lys Arg Leu Gly Ala His Thr Pro 
465                 470                 475 


<210>  908
<211>  22
<212>  PRT
<213>  Homo Sapiens

<400>  908

Met Ser Trp Pro Arg Arg Leu Leu Leu Arg Tyr Leu Phe Pro Ala Leu 
1               5                   10                  15      


Leu Leu His Ala Val Lys 
            20          


<210>  909
<211>  61
<212>  PRT
<213>  Homo Sapiens

<400>  909

Met Ser Trp Pro Arg Arg Leu Leu Leu Arg Tyr Leu Phe Pro Ala Leu 
1               5                   10                  15      


Leu Leu His Glu Pro Arg Pro Cys Leu His Arg Leu Ser Asp His Leu 
            20                  25                  30          


Ser Val Arg Arg Ala Pro Pro Ser His Pro Ala Pro Lys Gly Arg Pro 
        35                  40                  45              


Asp His Arg Pro Ala Arg Gly Val Gly Glu Pro Ala Leu 
    50                  55                  60      


<210>  910
<211>  184
<212>  PRT
<213>  Homo Sapiens

<400>  910

Met Ser Trp Pro Arg Arg Leu Leu Leu Arg Tyr Leu Phe Pro Ala Leu 
1               5                   10                  15      


Leu Leu His Gly Leu Gly Glu Gly Ser Ala Leu Leu His Pro Asp Ser 
            20                  25                  30          


Arg Ser His Pro Arg Ser Leu Glu Lys Ser Ala Trp Arg Ala Phe Lys 
        35                  40                  45              


Glu Ser Gln Cys His His Met Leu Lys His Leu His Asn Gly Ala Arg 
    50                  55                  60                  


Ile Thr Val Gln Met Pro Pro Thr Ile Glu Gly His Trp Val Ser Thr 
65                  70                  75                  80  


Gly Cys Glu Val Arg Ser Gly Pro Glu Phe Ile Thr Arg Ser Tyr Arg 
                85                  90                  95      


Phe Tyr His Asn Asn Thr Phe Lys Ala Tyr Gln Phe Tyr Tyr Gly Ser 
            100                 105                 110         


Asn Arg Cys Thr Asn Pro Thr Tyr Thr Leu Ile Ile Arg Gly Lys Ile 
        115                 120                 125             


Arg Leu Arg Gln Ala Ser Trp Ile Ile Arg Gly Gly Thr Glu Ala Asp 
    130                 135                 140                 


Tyr Gln Leu His Asn Val Gln Gly His Gly Arg His Arg Val Arg Val 
145                 150                 155                 160 


Gln Ser Glu Ser His Glu Gly His Pro His Gly Cys Gly His Ser Leu 
                165                 170                 175     


Thr Ala Gln Arg Leu Gln Arg Glu 
            180                 


<210>  911
<211>  514
<212>  PRT
<213>  Homo Sapiens

<400>  911

Met Ser Trp Pro Arg Arg Leu Leu Leu Arg Tyr Leu Phe Pro Ala Leu 
1               5                   10                  15      


Leu Leu His Gly Leu Gly Glu Gly Ser Ala Leu Leu His Pro Asp Ser 
            20                  25                  30          


Arg Ser His Pro Arg Ser Leu Glu Lys Ser Ala Trp Arg Ala Phe Lys 
        35                  40                  45              


Glu Ser Gln Cys His His Met Leu Lys His Leu His Asn Gly Ala Arg 
    50                  55                  60                  


Ile Thr Val Gln Met Pro Pro Thr Ile Glu Gly His Trp Val Ser Thr 
65                  70                  75                  80  


Gly Cys Glu Val Arg Ser Gly Pro Glu Phe Ile Thr Arg Ser Tyr Arg 
                85                  90                  95      


Phe Tyr His Asn Asn Thr Phe Lys Ala Tyr Gln Phe Tyr Tyr Gly Ser 
            100                 105                 110         


Asn Arg Cys Thr Asn Pro Thr Tyr Thr Leu Ile Ile Arg Gly Lys Ile 
        115                 120                 125             


Arg Leu Arg Gln Ala Ser Trp Ile Ile Arg Gly Gly Thr Glu Ala Asp 
    130                 135                 140                 


Tyr Gln Leu His Asn Val Gln Val Ile Cys His Thr Glu Ala Val Ala 
145                 150                 155                 160 


Glu Lys Leu Gly Gln Gln Val Asn Arg Thr Cys Pro Gly Phe Leu Ala 
                165                 170                 175     


Asp Gly Gly Pro Trp Val Gln Asp Val Ala Tyr Asp Leu Trp Arg Glu 
            180                 185                 190         


Glu Asn Gly Cys Glu Cys Thr Lys Ala Val Asn Phe Ala Met His Glu 
        195                 200                 205             


Leu Gln Leu Ile Arg Val Glu Lys Gln Tyr Leu His His Asn Leu Asp 
    210                 215                 220                 


His Leu Val Glu Glu Leu Phe Leu Gly Asp Ile His Thr Asp Ala Thr 
225                 230                 235                 240 


Gln Arg Met Phe Tyr Arg Pro Ser Ser Tyr Gln Pro Pro Leu Gln Asn 
                245                 250                 255     


Ala Lys Asn His Asp His Ala Cys Ile Ala Cys Arg Ile Ile Tyr Arg 
            260                 265                 270         


Ser Asp Glu His His Pro Pro Ile Leu Pro Pro Lys Ala Asp Leu Thr 
        275                 280                 285             


Ile Gly Leu His Gly Glu Trp Val Ser Gln Arg Cys Glu Val Arg Pro 
    290                 295                 300                 


Glu Val Leu Phe Leu Thr Arg His Phe Ile Phe His Asp Asn Asn Asn 
305                 310                 315                 320 


Thr Trp Glu Gly His Tyr Tyr His Tyr Ser Asp Pro Val Cys Lys His 
                325                 330                 335     


Pro Thr Phe Ser Ile Tyr Ala Arg Gly Arg Tyr Ser Arg Gly Val Leu 
            340                 345                 350         


Ser Ser Arg Val Met Gly Gly Thr Glu Phe Val Phe Lys Val Asn His 
        355                 360                 365             


Met Lys Val Thr Pro Met Asp Ala Ala Thr Ala Ser Leu Leu Asn Val 
    370                 375                 380                 


Phe Asn Gly Asn Glu Cys Gly Ala Glu Gly Ser Trp Gln Val Gly Ile 
385                 390                 395                 400 


Gln Gln Asp Val Thr His Thr Asn Gly Cys Val Ala Leu Gly Ile Lys 
                405                 410                 415     


Leu Pro His Thr Glu Tyr Glu Ile Phe Lys Met Glu Gln Asp Ala Arg 
            420                 425                 430         


Gly Arg Tyr Leu Leu Phe Asn Gly Gln Arg Pro Ser Asp Gly Ser Ser 
        435                 440                 445             


Pro Asp Arg Pro Glu Lys Arg Ala Thr Ser Tyr Gln Met Pro Leu Val 
    450                 455                 460                 


Gln Cys Ala Ser Ser Ser Pro Arg Ala Glu Asp Leu Ala Glu Asp Ser 
465                 470                 475                 480 


Gly Ser Ser Leu Tyr Gly Arg Ala Pro Gly Arg His Thr Trp Ser Leu 
                485                 490                 495     


Leu Leu Ala Ala Leu Ala Cys Leu Val Pro Leu Leu His Trp Asn Ile 
            500                 505                 510         


Arg Arg 
        


<210>  912
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  912

Pro Glu Asp Val Leu Pro Ala Leu Gln Leu Pro Ala Pro Ser Ala Glu 
1               5                   10                  15      


Cys Gln Val Glu Met Gly Phe His His Val Gly Gln Asp Gly Leu Gln 
            20                  25                  30          


Leu Pro Thr Ser Ser Asp Pro Pro Ala Leu Ala Ser Gln Ser Ala Gly 
        35                  40                  45              


Ile Thr Gly Val Ser His Arg Pro Pro Gly Arg His Leu Ser Asn Asp 
    50                  55                  60                  


Leu Arg Thr Thr Thr Met Pro Ala Ser Pro Val Gly Ser Ser Ile Gly 
65                  70                  75                  80  


Gln Thr Ser Thr Thr Leu Pro Ser Cys Pro Gln Arg Gln Thr 
                85                  90                  


<210>  913
<211>  227
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  913

Xaa Asp Val Ala Tyr Asp Leu Trp Arg Glu Glu Asn Gly Cys Glu Cys 
1               5                   10                  15      


Thr Lys Ala Val Asn Phe Ala Met His Glu Leu Gln Leu Ile Arg Val 
            20                  25                  30          


Glu Lys Gln Tyr Leu His His Asn Leu Asp His Leu Val Glu Glu Leu 
        35                  40                  45              


Phe Leu Gly Asp Ile His Thr Asp Ala Thr Gln Arg Met Phe Tyr Arg 
    50                  55                  60                  


Pro Ser Ser Tyr Gln Pro Pro Leu Gln Asn Ala Lys Cys Ala Ala Glu 
65                  70                  75                  80  


Ser Ser Gly Ser Phe Gln Ile Leu Pro Gln Asp Ser Ser Glu Lys Glu 
                85                  90                  95      


Gln Asn Gly Leu Ser His Trp Cys Leu Ser Arg Pro Gly His Gln Lys 
            100                 105                 110         


Asp Trp Ala Leu Cys Ala His Ala Gly Pro Ala Thr Ala Gly Cys Pro 
        115                 120                 125             


Ser Cys Leu Trp Pro Pro Ala Glu Thr Gly Arg Lys Ala Gly Arg Thr 
    130                 135                 140                 


Ser Ser Lys Thr Val His Ala Cys Pro Gly Glu Ala Gly Thr Ser Ser 
145                 150                 155                 160 


Phe Glu Leu Phe Tyr Phe Pro Asn Cys Trp Ser Ile Glu Thr Lys Leu 
                165                 170                 175     


Lys Ile Ser Leu Asn Ala Lys Leu Ser Phe Lys Pro Arg Ala Ser Ala 
            180                 185                 190         


Pro Leu Glu Thr Gly His Arg Val Lys Ile Glu Thr Leu Ser Gln Leu 
        195                 200                 205             


Val Phe Leu Ser Phe Ile Gln Leu Cys Cys Glu Val Gln Ser Pro Leu 
    210                 215                 220                 


Ala Asn Lys 
225         


<210>  914
<211>  223
<212>  PRT
<213>  Homo Sapiens

<400>  914

Met Asn Lys Pro Leu Leu Trp Ile Ser Val Leu Thr Ser Leu Leu Glu 
1               5                   10                  15      


Ala Phe Ala His Thr Asp Leu Ser Gly Lys Val Phe Val Phe Pro Arg 
            20                  25                  30          


Glu Ser Val Thr Asp His Val Asn Leu Ile Thr Pro Leu Glu Lys Pro 
        35                  40                  45              


Leu Gln Asn Phe Thr Leu Cys Phe Arg Ala Tyr Ser Asp Leu Ser Arg 
    50                  55                  60                  


Ala Tyr Ser Leu Phe Ser Tyr Asn Thr Gln Gly Arg Asp Asn Glu Leu 
65                  70                  75                  80  


Leu Val Tyr Lys Glu Arg Val Gly Glu Tyr Ser Leu Tyr Ile Gly Arg 
                85                  90                  95      


His Lys Val Thr Ser Lys Val Ile Glu Lys Phe Pro Ala Pro Val His 
            100                 105                 110         


Ile Cys Val Ser Trp Glu Ser Ser Ser Gly Ile Ala Glu Phe Trp Ile 
        115                 120                 125             


Asn Gly Thr Pro Leu Val Lys Lys Gly Leu Arg Gln Gly Tyr Phe Val 
    130                 135                 140                 


Glu Ala Gln Pro Lys Ile Val Leu Gly Gln Glu Gln Asp Ser Tyr Gly 
145                 150                 155                 160 


Gly Lys Phe Asp Arg Ser Gln Ser Phe Val Gly Glu Ile Gly Asp Leu 
                165                 170                 175     


Tyr Met Trp Asp Ser Val Leu Pro Pro Glu Asn Ile Leu Ser Ala Tyr 
            180                 185                 190         


Gln Gly Thr Pro Leu Pro Ala Asn Ile Leu Asp Trp Gln Ala Leu Asn 
        195                 200                 205             


Tyr Glu Ile Arg Gly Tyr Val Ile Ile Lys Pro Leu Val Trp Val 
    210                 215                 220             


<210>  915
<211>  54
<212>  PRT
<213>  Homo Sapiens

<400>  915

Met Arg Phe Gln Gln Phe Leu Phe Ala Phe Phe Ile Phe Ile Met Ser 
1               5                   10                  15      


Leu Leu Leu Ile Ser Gly Gln Arg Pro Val Asn Leu Thr Met Arg Arg 
            20                  25                  30          


Lys Leu Arg Lys His Asn Cys Leu Gln Arg Arg Cys Met Pro Leu His 
        35                  40                  45              


Ser Arg Val Pro Phe Pro 
    50                  


<210>  916
<211>  54
<212>  PRT
<213>  Homo Sapiens

<400>  916

Met Arg Phe Gln Gln Phe Leu Phe Ala Phe Phe Ile Phe Ile Met Ser 
1               5                   10                  15      


Leu Leu Leu Ile Ser Gly Gln Arg Pro Val Asn Leu Thr Met Arg Arg 
            20                  25                  30          


Lys Leu Arg Lys His Asn Cys Leu Gln Arg Arg Cys Met Pro Leu His 
        35                  40                  45              


Ser Arg Val Pro Phe Pro 
    50                  


<210>  917
<211>  54
<212>  PRT
<213>  Homo Sapiens

<400>  917

Met Arg Phe Gln Gln Phe Leu Phe Ala Phe Phe Ile Phe Ile Met Ser 
1               5                   10                  15      


Leu Leu Leu Ile Ser Gly Gln Arg Pro Val Asn Leu Thr Met Arg Arg 
            20                  25                  30          


Lys Leu Arg Lys His Asn Cys Leu Gln Arg Arg Cys Met Pro Leu His 
        35                  40                  45              


Ser Arg Val Pro Phe Pro 
    50                  


<210>  918
<211>  77
<212>  PRT
<213>  Homo Sapiens

<400>  918

Met Asn Leu Arg Leu Cys Val Gln Ala Leu Leu Leu Leu Trp Leu Ser 
1               5                   10                  15      


Leu Thr Ala Val Cys Gly Gly Ser Leu Met Pro Leu Pro Asp Gly Asn 
            20                  25                  30          


Gly Leu Glu Asp Gly Asn Val Arg His Leu Val Gln Pro Arg Gly Ser 
        35                  40                  45              


Arg Asn Gly Pro Gly Pro Trp Gln Gly Gly Arg Arg Lys Phe Arg Arg 
    50                  55                  60                  


Gln Arg Pro Arg Leu Ser His Lys Gly Pro Met Pro Phe 
65                  70                  75          


<210>  919
<211>  158
<212>  PRT
<213>  Homo Sapiens

<400>  919

Met Ala Ala Thr Gly Thr Ala Ala Ala Ala Ala Thr Gly Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ala Leu Ala Ala Asn Ala Gly Thr Gly Phe Ala Val 
            20                  25                  30          


Ala Glu Pro Gln Ile Ala Met Phe Cys Gly Lys Leu Asn Met His Val 
        35                  40                  45              


Asn Ile Gln Thr Gly Lys Trp Glu Pro Asp Pro Thr Gly Thr Lys Ser 
    50                  55                  60                  


Cys Phe Glu Thr Lys Glu Glu Val Leu Gln Tyr Cys Gln Glu Met Tyr 
65                  70                  75                  80  


Pro Glu Leu Gln Ile Thr Asn Val Met Glu Ala Asn Gln Arg Val Ser 
                85                  90                  95      


Ile Asp Asn Trp Cys Arg Arg Asp Lys Lys Gln Cys Lys Ser Arg Phe 
            100                 105                 110         


Val Thr Pro Phe Lys Cys Leu Val Gly Glu Phe Val Ser Asp Val Leu 
        115                 120                 125             


Leu Val Pro Glu Lys Cys Gln Phe Phe His Lys Glu Arg Met Glu Val 
    130                 135                 140                 


Cys Glu Asn His Gln His Trp His Thr Val Val Lys Glu Val 
145                 150                 155             


<210>  920
<211>  35
<212>  PRT
<213>  Homo Sapiens

<400>  920

Met Ala Ala Thr Gly Thr Ala Ala Ala Ala Ala Thr Gly Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Val Gly Leu Thr Ala Pro Ala Leu Ala Leu Ala Gly 
            20                  25                  30          


Tyr Ile Glu 
        35  


<210>  921
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  921

Met Ala Ala Thr Gly Thr Ala Ala Ala Ala Ala Thr Gly Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Val Gly Leu Thr Ala Pro Ala Leu Ala Leu Ala Gly 
            20                  25                  30          


Tyr Ile Glu Ala Leu Ala Ala Asn Ala Gly Thr Gly Phe Ala Val Ala 
        35                  40                  45              


Glu Pro Gln Ile Ala Met Phe Cys Gly Lys Leu Asn Met His Val Asn 
    50                  55                  60                  


Ile Gln Thr Gly Lys Trp Glu Pro Asp Pro Thr Gly Thr Lys Ser Cys 
65                  70                  75                  80  


Phe Glu Thr Lys Glu Glu Val Leu Gln Tyr Cys Gln Glu Met Tyr Pro 
                85                  90                  95      


Glu Leu Gln Ile Thr Asn Ser Gly Trp Arg Cys Val Arg Ile Thr Ser 
            100                 105                 110         


Thr Gly Thr Arg 
        115     


<210>  922
<211>  763
<212>  PRT
<213>  Homo Sapiens

<400>  922

Met Ala Ala Thr Gly Thr Ala Ala Ala Ala Ala Thr Gly Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Val Gly Leu Thr Ala Pro Ala Leu Ala Leu Ala Gly 
            20                  25                  30          


Tyr Ile Glu Ala Leu Ala Ala Asn Ala Gly Thr Gly Phe Ala Val Ala 
        35                  40                  45              


Glu Pro Gln Ile Ala Met Phe Cys Gly Lys Leu Asn Met His Val Asn 
    50                  55                  60                  


Ile Gln Thr Gly Lys Trp Glu Pro Asp Pro Thr Gly Thr Lys Ser Cys 
65                  70                  75                  80  


Phe Glu Thr Lys Glu Glu Val Leu Gln Tyr Cys Gln Glu Met Tyr Pro 
                85                  90                  95      


Glu Leu Gln Ile Thr Asn Val Met Glu Ala Asn Gln Arg Val Ser Ile 
            100                 105                 110         


Asp Asn Trp Cys Arg Arg Asp Lys Lys Gln Cys Lys Ser Arg Phe Val 
        115                 120                 125             


Thr Pro Phe Lys Cys Leu Val Gly Glu Phe Val Ser Asp Val Leu Leu 
    130                 135                 140                 


Val Pro Glu Lys Cys Gln Phe Phe His Lys Glu Arg Met Glu Val Cys 
145                 150                 155                 160 


Glu Asn His Gln His Trp His Thr Val Val Lys Glu Ala Cys Leu Thr 
                165                 170                 175     


Gln Gly Met Thr Leu Tyr Ser Tyr Gly Met Leu Leu Pro Cys Gly Val 
            180                 185                 190         


Asp Gln Phe His Gly Thr Glu Tyr Val Cys Cys Pro Gln Thr Lys Ile 
        195                 200                 205             


Ile Gly Ser Val Ser Lys Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu 
    210                 215                 220                 


Glu Glu Glu Asp Glu Glu Glu Asp Tyr Asp Val Tyr Lys Ser Glu Phe 
225                 230                 235                 240 


Pro Thr Glu Ala Asp Leu Glu Asp Phe Thr Glu Ala Ala Val Asp Glu 
                245                 250                 255     


Asp Asp Glu Asp Glu Glu Glu Gly Glu Glu Val Val Glu Asp Arg Asp 
            260                 265                 270         


Tyr Tyr Tyr Asp Thr Phe Lys Gly Asp Asp Tyr Asn Glu Glu Asn Pro 
        275                 280                 285             


Thr Glu Pro Gly Ser Asp Gly Thr Met Ser Asp Lys Glu Ile Thr His 
    290                 295                 300                 


Asp Val Lys Ala Val Cys Ser Gln Glu Ala Met Thr Gly Pro Cys Arg 
305                 310                 315                 320 


Ala Val Met Pro Arg Trp Tyr Phe Asp Leu Ser Lys Gly Lys Cys Val 
                325                 330                 335     


Arg Phe Ile Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Glu Ser 
            340                 345                 350         


Glu Asp Tyr Cys Met Ala Val Cys Lys Ala Met Ile Pro Pro Thr Pro 
        355                 360                 365             


Leu Pro Thr Asn Asp Val Asp Val Tyr Phe Glu Thr Ser Ala Asp Asp 
    370                 375                 380                 


Asn Glu His Ala Arg Phe Gln Lys Ala Lys Glu Gln Leu Glu Ile Arg 
385                 390                 395                 400 


His Arg Asn Arg Met Asp Arg Val Lys Lys Glu Trp Glu Glu Ala Glu 
                405                 410                 415     


Leu Gln Ala Lys Asn Leu Pro Lys Ala Glu Arg Gln Thr Leu Ile Gln 
            420                 425                 430         


His Phe Gln Ala Met Val Lys Ala Leu Glu Lys Glu Ala Ala Ser Glu 
        435                 440                 445             


Lys Gln Gln Leu Val Glu Thr His Leu Ala Arg Val Glu Ala Met Leu 
    450                 455                 460                 


Asn Asp Arg Arg Arg Met Ala Leu Glu Asn Tyr Leu Ala Ala Leu Gln 
465                 470                 475                 480 


Ser Asp Pro Pro Arg Pro His Arg Ile Leu Gln Ala Leu Arg Arg Tyr 
                485                 490                 495     


Val Arg Ala Glu Asn Lys Asp Arg Leu His Thr Ile Arg His Tyr Gln 
            500                 505                 510         


His Val Leu Ala Val Asp Pro Glu Lys Ala Ala Gln Met Lys Ser Gln 
        515                 520                 525             


Val Met Thr His Leu His Val Ile Glu Glu Arg Arg Asn Gln Ser Leu 
    530                 535                 540                 


Ser Leu Leu Tyr Lys Val Pro Tyr Val Ala Gln Glu Ile Gln Glu Glu 
545                 550                 555                 560 


Ile Asp Glu Leu Leu Gln Glu Gln Arg Ala Asp Met Asp Gln Phe Thr 
                565                 570                 575     


Ala Ser Ile Ser Glu Thr Pro Val Asp Val Arg Val Ser Ser Glu Glu 
            580                 585                 590         


Ser Glu Glu Ile Pro Pro Phe His Pro Phe His Pro Phe Pro Ala Leu 
        595                 600                 605             


Pro Glu Asn Glu Asp Thr Gln Pro Glu Leu Tyr His Pro Met Lys Lys 
    610                 615                 620                 


Gly Ser Gly Val Gly Glu Gln Asp Gly Gly Leu Ile Gly Ala Glu Glu 
625                 630                 635                 640 


Lys Val Ile Asn Ser Lys Asn Lys Val Asp Glu Asn Met Val Ile Asp 
                645                 650                 655     


Glu Thr Leu Asp Val Lys Glu Met Ile Phe Asn Ala Glu Arg Val Gly 
            660                 665                 670         


Gly Leu Glu Glu Glu Arg Glu Ser Val Gly Pro Leu Arg Glu Asp Phe 
        675                 680                 685             


Ser Leu Ser Ser Ser Ala Leu Ile Gly Leu Leu Val Ile Ala Val Ala 
    690                 695                 700                 


Ile Ala Thr Val Ile Val Ile Ser Leu Val Met Leu Arg Lys Arg Gln 
705                 710                 715                 720 


Tyr Gly Thr Ile Ser His Gly Ile Val Glu Val Asp Pro Met Leu Thr 
                725                 730                 735     


Pro Glu Glu Arg His Leu Asn Lys Met Gln Asn His Gly Tyr Glu Asn 
            740                 745                 750         


Pro Thr Tyr Lys Tyr Leu Glu Gln Met Gln Ile 
        755                 760             


<210>  923
<211>  751
<212>  PRT
<213>  Homo Sapiens

<400>  923

Met Ala Ala Thr Gly Thr Ala Ala Ala Ala Ala Thr Gly Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Val Gly Leu Thr Ala Pro Ala Leu Ala Leu Ala Gly 
            20                  25                  30          


Tyr Ile Glu Ala Leu Ala Ala Asn Ala Gly Thr Gly Phe Ala Val Ala 
        35                  40                  45              


Glu Pro Gln Ile Ala Met Phe Cys Gly Lys Leu Asn Met His Val Asn 
    50                  55                  60                  


Ile Gln Thr Gly Lys Trp Glu Pro Asp Pro Thr Gly Thr Lys Ser Cys 
65                  70                  75                  80  


Phe Glu Thr Lys Glu Glu Val Leu Gln Tyr Cys Gln Glu Met Tyr Pro 
                85                  90                  95      


Glu Leu Gln Ile Thr Asn Val Met Glu Ala Asn Gln Arg Val Ser Ile 
            100                 105                 110         


Asp Asn Trp Cys Arg Arg Asp Lys Lys Gln Cys Lys Ser Arg Phe Val 
        115                 120                 125             


Thr Pro Phe Lys Cys Leu Val Gly Glu Phe Val Ser Asp Val Leu Leu 
    130                 135                 140                 


Val Pro Glu Lys Cys Gln Phe Phe His Lys Glu Arg Met Glu Val Cys 
145                 150                 155                 160 


Glu Asn His Gln His Trp His Thr Val Val Lys Glu Ala Cys Leu Thr 
                165                 170                 175     


Gln Gly Met Thr Leu Tyr Ser Tyr Gly Met Leu Leu Pro Cys Gly Val 
            180                 185                 190         


Asp Gln Phe His Gly Thr Glu Tyr Val Cys Cys Pro Gln Thr Lys Ile 
        195                 200                 205             


Ile Gly Ser Val Ser Lys Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu 
    210                 215                 220                 


Glu Glu Glu Asp Glu Glu Glu Asp Tyr Asp Val Tyr Lys Ser Glu Phe 
225                 230                 235                 240 


Pro Thr Glu Ala Asp Leu Glu Asp Phe Thr Glu Ala Ala Val Asp Glu 
                245                 250                 255     


Asp Asp Glu Asp Glu Glu Glu Gly Glu Glu Val Val Glu Asp Arg Asp 
            260                 265                 270         


Tyr Tyr Tyr Asp Thr Phe Lys Gly Asp Asp Tyr Asn Glu Glu Asn Pro 
        275                 280                 285             


Thr Glu Pro Gly Ser Asp Gly Thr Met Ser Asp Lys Glu Ile Thr His 
    290                 295                 300                 


Asp Val Lys Ala Val Cys Ser Gln Glu Ala Met Thr Gly Pro Cys Arg 
305                 310                 315                 320 


Ala Val Met Pro Arg Trp Tyr Phe Asp Leu Ser Lys Gly Lys Cys Val 
                325                 330                 335     


Arg Phe Ile Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Glu Ser 
            340                 345                 350         


Glu Asp Tyr Cys Met Ala Val Cys Lys Ala Met Ile Pro Pro Thr Pro 
        355                 360                 365             


Leu Pro Thr Asn Asp Val Asp Val Tyr Phe Glu Thr Ser Ala Asp Asp 
    370                 375                 380                 


Asn Glu His Ala Arg Phe Gln Lys Ala Lys Glu Gln Leu Glu Ile Arg 
385                 390                 395                 400 


His Arg Asn Arg Met Asp Arg Val Lys Lys Glu Trp Glu Glu Ala Glu 
                405                 410                 415     


Leu Gln Ala Lys Asn Leu Pro Lys Ala Glu Arg Gln Thr Leu Ile Gln 
            420                 425                 430         


His Phe Gln Ala Met Val Lys Ala Leu Glu Lys Glu Ala Ala Ser Glu 
        435                 440                 445             


Lys Gln Gln Leu Val Glu Thr His Leu Ala Arg Val Glu Ala Met Leu 
    450                 455                 460                 


Asn Asp Arg Arg Arg Met Ala Leu Glu Asn Tyr Leu Ala Ala Leu Gln 
465                 470                 475                 480 


Ser Asp Pro Pro Arg Pro His Arg Ile Leu Gln Ala Leu Arg Arg Tyr 
                485                 490                 495     


Val Arg Ala Glu Asn Lys Asp Arg Leu His Thr Ile Arg His Tyr Gln 
            500                 505                 510         


His Val Leu Ala Val Asp Pro Glu Lys Ala Ala Gln Met Lys Ser Gln 
        515                 520                 525             


Val Met Thr His Leu His Val Ile Glu Glu Arg Arg Asn Gln Ser Leu 
    530                 535                 540                 


Ser Leu Leu Tyr Lys Val Pro Tyr Val Ala Gln Glu Ile Gln Glu Glu 
545                 550                 555                 560 


Ile Asp Glu Leu Leu Gln Glu Gln Arg Ala Asp Met Asp Gln Phe Thr 
                565                 570                 575     


Ala Ser Ile Ser Glu Thr Pro Val Asp Val Arg Val Ser Ser Glu Glu 
            580                 585                 590         


Ser Glu Glu Ile Pro Pro Phe His Pro Phe His Pro Phe Pro Ala Leu 
        595                 600                 605             


Pro Glu Asn Glu Gly Ser Gly Val Gly Glu Gln Asp Gly Gly Leu Ile 
    610                 615                 620                 


Gly Ala Glu Glu Lys Val Ile Asn Ser Lys Asn Lys Val Asp Glu Asn 
625                 630                 635                 640 


Met Val Ile Asp Glu Thr Leu Asp Val Lys Glu Met Ile Phe Asn Ala 
                645                 650                 655     


Glu Arg Val Gly Gly Leu Glu Glu Glu Arg Glu Ser Val Gly Pro Leu 
            660                 665                 670         


Arg Glu Asp Phe Ser Leu Ser Ser Ser Ala Leu Ile Gly Leu Leu Val 
        675                 680                 685             


Ile Ala Val Ala Ile Ala Thr Val Ile Val Ile Ser Leu Val Met Leu 
    690                 695                 700                 


Arg Lys Arg Gln Tyr Gly Thr Ile Ser His Gly Ile Val Glu Val Asp 
705                 710                 715                 720 


Pro Met Leu Thr Pro Glu Glu Arg His Leu Asn Lys Met Gln Asn His 
                725                 730                 735     


Gly Tyr Glu Asn Pro Thr Tyr Lys Tyr Leu Glu Gln Met Gln Ile 
            740                 745                 750     


<210>  924
<211>  695
<212>  PRT
<213>  Homo Sapiens

<400>  924

Met Ala Ala Thr Gly Thr Ala Ala Ala Ala Ala Thr Gly Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Val Gly Leu Thr Ala Pro Ala Leu Ala Leu Ala Gly 
            20                  25                  30          


Tyr Ile Glu Ala Leu Ala Ala Asn Ala Gly Thr Gly Phe Ala Val Ala 
        35                  40                  45              


Glu Pro Gln Ile Ala Met Phe Cys Gly Lys Leu Asn Met His Val Asn 
    50                  55                  60                  


Ile Gln Thr Gly Lys Trp Glu Pro Asp Pro Thr Gly Thr Lys Ser Cys 
65                  70                  75                  80  


Phe Glu Thr Lys Glu Glu Val Leu Gln Tyr Cys Gln Glu Met Tyr Pro 
                85                  90                  95      


Glu Leu Gln Ile Thr Asn Val Met Glu Ala Asn Gln Arg Val Ser Ile 
            100                 105                 110         


Asp Asn Trp Cys Arg Arg Asp Lys Lys Gln Cys Lys Ser Arg Phe Val 
        115                 120                 125             


Thr Pro Phe Lys Cys Leu Val Gly Glu Phe Val Ser Asp Val Leu Leu 
    130                 135                 140                 


Val Pro Glu Lys Cys Gln Phe Phe His Lys Glu Arg Met Glu Val Cys 
145                 150                 155                 160 


Glu Asn His Gln His Trp His Thr Val Val Lys Glu Ala Cys Leu Thr 
                165                 170                 175     


Gln Gly Met Thr Leu Tyr Ser Tyr Gly Met Leu Leu Pro Cys Gly Val 
            180                 185                 190         


Asp Gln Phe His Gly Thr Glu Tyr Val Cys Cys Pro Gln Thr Lys Ile 
        195                 200                 205             


Ile Gly Ser Val Ser Lys Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu 
    210                 215                 220                 


Glu Glu Glu Asp Glu Glu Glu Asp Tyr Asp Val Tyr Lys Ser Glu Phe 
225                 230                 235                 240 


Pro Thr Glu Ala Asp Leu Glu Asp Phe Thr Glu Ala Ala Val Asp Glu 
                245                 250                 255     


Asp Asp Glu Asp Glu Glu Glu Gly Glu Glu Val Val Glu Asp Arg Asp 
            260                 265                 270         


Tyr Tyr Tyr Asp Thr Phe Lys Gly Asp Asp Tyr Asn Glu Glu Asn Pro 
        275                 280                 285             


Thr Glu Pro Gly Ser Asp Gly Thr Met Ser Asp Lys Glu Ile Thr His 
    290                 295                 300                 


Asp Val Lys Val Pro Pro Thr Pro Leu Pro Thr Asn Asp Val Asp Val 
305                 310                 315                 320 


Tyr Phe Glu Thr Ser Ala Asp Asp Asn Glu His Ala Arg Phe Gln Lys 
                325                 330                 335     


Ala Lys Glu Gln Leu Glu Ile Arg His Arg Asn Arg Met Asp Arg Val 
            340                 345                 350         


Lys Lys Glu Trp Glu Glu Ala Glu Leu Gln Ala Lys Asn Leu Pro Lys 
        355                 360                 365             


Ala Glu Arg Gln Thr Leu Ile Gln His Phe Gln Ala Met Val Lys Ala 
    370                 375                 380                 


Leu Glu Lys Glu Ala Ala Ser Glu Lys Gln Gln Leu Val Glu Thr His 
385                 390                 395                 400 


Leu Ala Arg Val Glu Ala Met Leu Asn Asp Arg Arg Arg Met Ala Leu 
                405                 410                 415     


Glu Asn Tyr Leu Ala Ala Leu Gln Ser Asp Pro Pro Arg Pro His Arg 
            420                 425                 430         


Ile Leu Gln Ala Leu Arg Arg Tyr Val Arg Ala Glu Asn Lys Asp Arg 
        435                 440                 445             


Leu His Thr Ile Arg His Tyr Gln His Val Leu Ala Val Asp Pro Glu 
    450                 455                 460                 


Lys Ala Ala Gln Met Lys Ser Gln Val Met Thr His Leu His Val Ile 
465                 470                 475                 480 


Glu Glu Arg Arg Asn Gln Ser Leu Ser Leu Leu Tyr Lys Val Pro Tyr 
                485                 490                 495     


Val Ala Gln Glu Ile Gln Glu Glu Ile Asp Glu Leu Leu Gln Glu Gln 
            500                 505                 510         


Arg Ala Asp Met Asp Gln Phe Thr Ala Ser Ile Ser Glu Thr Pro Val 
        515                 520                 525             


Asp Val Arg Val Ser Ser Glu Glu Ser Glu Glu Ile Pro Pro Phe His 
    530                 535                 540                 


Pro Phe His Pro Phe Pro Ala Leu Pro Glu Asn Glu Gly Ser Gly Val 
545                 550                 555                 560 


Gly Glu Gln Asp Gly Gly Leu Ile Gly Ala Glu Glu Lys Val Ile Asn 
                565                 570                 575     


Ser Lys Asn Lys Val Asp Glu Asn Met Val Ile Asp Glu Thr Leu Asp 
            580                 585                 590         


Val Lys Glu Met Ile Phe Asn Ala Glu Arg Val Gly Gly Leu Glu Glu 
        595                 600                 605             


Glu Arg Glu Ser Val Gly Pro Leu Arg Glu Asp Phe Ser Leu Ser Ser 
    610                 615                 620                 


Ser Ala Leu Ile Gly Leu Leu Val Ile Ala Val Ala Ile Ala Thr Val 
625                 630                 635                 640 


Ile Val Ile Ser Leu Val Met Leu Arg Lys Arg Gln Tyr Gly Thr Ile 
                645                 650                 655     


Ser His Gly Ile Val Glu Val Asp Pro Met Leu Thr Pro Glu Glu Arg 
            660                 665                 670         


His Leu Asn Lys Met Gln Asn His Gly Tyr Glu Asn Pro Thr Tyr Lys 
        675                 680                 685             


Tyr Leu Glu Gln Met Gln Ile 
    690                 695 


<210>  925
<211>  522
<212>  PRT
<213>  Homo Sapiens

<400>  925

Met Ala Ala Thr Gly Thr Ala Ala Ala Ala Ala Thr Gly Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Val Gly Leu Thr Ala Pro Ala Leu Ala Leu Ala Gly 
            20                  25                  30          


Tyr Ile Glu Ala Leu Ala Ala Asn Ala Gly Thr Gly Phe Ala Val Ala 
        35                  40                  45              


Glu Pro Gln Ile Ala Met Phe Cys Gly Lys Leu Asn Met His Val Asn 
    50                  55                  60                  


Ile Gln Thr Gly Lys Trp Glu Pro Asp Pro Thr Gly Thr Lys Ser Cys 
65                  70                  75                  80  


Phe Glu Thr Lys Glu Glu Val Leu Gln Tyr Cys Gln Glu Met Tyr Pro 
                85                  90                  95      


Glu Leu Gln Ile Thr Asn Val Met Glu Ala Asn Gln Arg Val Ser Ile 
            100                 105                 110         


Asp Asn Trp Cys Arg Arg Asp Lys Lys Gln Cys Lys Ser Arg Phe Val 
        115                 120                 125             


Thr Pro Phe Lys Cys Leu Val Pro Pro Thr Pro Leu Pro Thr Asn Asp 
    130                 135                 140                 


Val Asp Val Tyr Phe Glu Thr Ser Ala Asp Asp Asn Glu His Ala Arg 
145                 150                 155                 160 


Phe Gln Lys Ala Lys Glu Gln Leu Glu Ile Arg His Arg Asn Arg Met 
                165                 170                 175     


Asp Arg Val Lys Lys Glu Trp Glu Glu Ala Glu Leu Gln Ala Lys Asn 
            180                 185                 190         


Leu Pro Lys Ala Glu Arg Gln Thr Leu Ile Gln His Phe Gln Ala Met 
        195                 200                 205             


Val Lys Ala Leu Glu Lys Glu Ala Ala Ser Glu Lys Gln Gln Leu Val 
    210                 215                 220                 


Glu Thr His Leu Ala Arg Val Glu Ala Met Leu Asn Asp Arg Arg Arg 
225                 230                 235                 240 


Met Ala Leu Glu Asn Tyr Leu Ala Ala Leu Gln Ser Asp Pro Pro Arg 
                245                 250                 255     


Pro His Arg Ile Leu Gln Ala Leu Arg Arg Tyr Val Arg Ala Glu Asn 
            260                 265                 270         


Lys Asp Arg Leu His Thr Ile Arg His Tyr Gln His Val Leu Ala Val 
        275                 280                 285             


Asp Pro Glu Lys Ala Ala Gln Met Lys Ser Gln Val Met Thr His Leu 
    290                 295                 300                 


His Val Ile Glu Glu Arg Arg Asn Gln Ser Leu Ser Leu Leu Tyr Lys 
305                 310                 315                 320 


Val Pro Tyr Val Ala Gln Glu Ile Gln Glu Glu Ile Asp Glu Leu Leu 
                325                 330                 335     


Gln Glu Gln Arg Ala Asp Met Asp Gln Phe Thr Ala Ser Ile Ser Glu 
            340                 345                 350         


Thr Pro Val Asp Val Arg Val Ser Ser Glu Glu Ser Glu Glu Ile Pro 
        355                 360                 365             


Pro Phe His Pro Phe His Pro Phe Pro Ala Leu Pro Glu Asn Glu Gly 
    370                 375                 380                 


Ser Gly Val Gly Glu Gln Asp Gly Gly Leu Ile Gly Ala Glu Glu Lys 
385                 390                 395                 400 


Val Ile Asn Ser Lys Asn Lys Val Asp Glu Asn Met Val Ile Asp Glu 
                405                 410                 415     


Thr Leu Asp Val Lys Glu Met Ile Phe Asn Ala Glu Arg Val Gly Gly 
            420                 425                 430         


Leu Glu Glu Glu Arg Glu Ser Val Gly Pro Leu Arg Glu Asp Phe Ser 
        435                 440                 445             


Leu Ser Ser Ser Ala Leu Ile Gly Leu Leu Val Ile Ala Val Ala Ile 
    450                 455                 460                 


Ala Thr Val Ile Val Ile Ser Leu Val Met Leu Arg Lys Arg Gln Tyr 
465                 470                 475                 480 


Gly Thr Ile Ser His Gly Ile Val Glu Val Asp Pro Met Leu Thr Pro 
                485                 490                 495     


Glu Glu Arg His Leu Asn Lys Met Gln Asn His Gly Tyr Glu Asn Pro 
            500                 505                 510         


Thr Tyr Lys Tyr Leu Glu Gln Met Gln Ile 
        515                 520         


<210>  926
<211>  159
<212>  PRT
<213>  Homo Sapiens

<400>  926

Met Ala Ala Thr Gly Thr Ala Ala Ala Ala Ala Thr Gly Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Val Gly Leu Thr Ala Pro Ala Leu Ala Leu Ala Gly 
            20                  25                  30          


Tyr Ile Glu Ser Ser Gln Ile Cys Cys Ser Pro Arg Ser Phe Leu Ile 
        35                  40                  45              


Ser Thr Leu Lys Cys Leu Ile Val Asp Glu Ile Asn Ala Leu Ala Ala 
    50                  55                  60                  


Asn Ala Gly Thr Gly Phe Ala Val Ala Glu Pro Gln Ile Ala Met Phe 
65                  70                  75                  80  


Cys Gly Lys Leu Asn Met His Val Asn Ile Gln Thr Gly Lys Trp Glu 
                85                  90                  95      


Pro Asp Pro Thr Gly Thr Lys Ser Cys Phe Glu Thr Lys Glu Glu Val 
            100                 105                 110         


Leu Gln Tyr Cys Gln Glu Met Tyr Pro Glu Leu Gln Ile Thr Asn Val 
        115                 120                 125             


Met Glu Ala Asn Gln Arg Val Ser Ile Asp Asn Trp Cys Arg Arg Asp 
    130                 135                 140                 


Lys Lys Gln Cys Lys Ser Arg Phe Val Thr Pro Phe Lys Cys Leu 
145                 150                 155                 


<210>  927
<211>  39
<212>  PRT
<213>  Homo Sapiens

<400>  927

Met Ala Ala Thr Gly Thr Ala Ala Ala Ala Ala Thr Gly Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Val Gly Leu Thr Ala Pro Ala Leu Ala Leu Ala Gly 
            20                  25                  30          


Tyr Ile Glu Trp Val Asn Leu 
        35                  


<210>  928
<211>  761
<212>  PRT
<213>  Homo Sapiens

<400>  928

Met Leu Arg Ala Pro Gly Glu Leu Pro Arg Gln Ala Ala Arg Cys Ser 
1               5                   10                  15      


Leu Cys Arg Leu Gly Pro Gly Arg Gly Arg Ala Phe Phe Lys Trp Arg 
            20                  25                  30          


Cys Leu Pro Ala Ser Val Asp Arg Gly Asn Pro Leu Trp Ala Leu Ala 
        35                  40                  45              


Ala Asn Ala Gly Thr Gly Phe Ala Val Ala Glu Pro Gln Ile Ala Met 
    50                  55                  60                  


Phe Cys Gly Lys Leu Asn Met His Val Asn Ile Gln Thr Gly Lys Trp 
65                  70                  75                  80  


Glu Pro Asp Pro Thr Gly Thr Lys Ser Cys Phe Glu Thr Lys Glu Glu 
                85                  90                  95      


Val Leu Gln Tyr Cys Gln Glu Met Tyr Pro Glu Leu Gln Ile Thr Asn 
            100                 105                 110         


Val Met Glu Ala Asn Gln Arg Val Ser Ile Asp Asn Trp Cys Arg Arg 
        115                 120                 125             


Asp Lys Lys Gln Cys Lys Ser Arg Phe Val Thr Pro Phe Lys Cys Leu 
    130                 135                 140                 


Val Gly Glu Phe Val Ser Asp Val Leu Leu Val Pro Glu Lys Cys Gln 
145                 150                 155                 160 


Phe Phe His Lys Glu Arg Met Glu Val Cys Glu Asn His Gln His Trp 
                165                 170                 175     


His Thr Val Val Lys Glu Ala Cys Leu Thr Gln Gly Met Thr Leu Tyr 
            180                 185                 190         


Ser Tyr Gly Met Leu Leu Pro Cys Gly Val Asp Gln Phe His Gly Thr 
        195                 200                 205             


Glu Tyr Val Cys Cys Pro Gln Thr Lys Ile Ile Gly Ser Val Ser Lys 
    210                 215                 220                 


Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Asp Glu Glu 
225                 230                 235                 240 


Glu Asp Tyr Asp Val Tyr Lys Ser Glu Phe Pro Thr Glu Ala Asp Leu 
                245                 250                 255     


Glu Asp Phe Thr Glu Ala Ala Val Asp Glu Asp Asp Glu Asp Glu Glu 
            260                 265                 270         


Glu Gly Glu Glu Val Val Glu Asp Arg Asp Tyr Tyr Tyr Asp Thr Phe 
        275                 280                 285             


Lys Gly Asp Asp Tyr Asn Glu Glu Asn Pro Thr Glu Pro Gly Ser Asp 
    290                 295                 300                 


Gly Thr Met Ser Asp Lys Glu Ile Thr His Asp Val Lys Ala Val Cys 
305                 310                 315                 320 


Ser Gln Glu Ala Met Thr Gly Pro Cys Arg Ala Val Met Pro Arg Trp 
                325                 330                 335     


Tyr Phe Asp Leu Ser Lys Gly Lys Cys Val Arg Phe Ile Tyr Gly Gly 
            340                 345                 350         


Cys Gly Gly Asn Arg Asn Asn Phe Glu Ser Glu Asp Tyr Cys Met Ala 
        355                 360                 365             


Val Cys Lys Ala Met Ile Pro Pro Thr Pro Leu Pro Thr Asn Asp Val 
    370                 375                 380                 


Asp Val Tyr Phe Glu Thr Ser Ala Asp Asp Asn Glu His Ala Arg Phe 
385                 390                 395                 400 


Gln Lys Ala Lys Glu Gln Leu Glu Ile Arg His Arg Asn Arg Met Asp 
                405                 410                 415     


Arg Val Lys Lys Glu Trp Glu Glu Ala Glu Leu Gln Ala Lys Asn Leu 
            420                 425                 430         


Pro Lys Ala Glu Arg Gln Thr Leu Ile Gln His Phe Gln Ala Met Val 
        435                 440                 445             


Lys Ala Leu Glu Lys Glu Ala Ala Ser Glu Lys Gln Gln Leu Val Glu 
    450                 455                 460                 


Thr His Leu Ala Arg Val Glu Ala Met Leu Asn Asp Arg Arg Arg Met 
465                 470                 475                 480 


Ala Leu Glu Asn Tyr Leu Ala Ala Leu Gln Ser Asp Pro Pro Arg Pro 
                485                 490                 495     


His Arg Ile Leu Gln Ala Leu Arg Arg Tyr Val Arg Ala Glu Asn Lys 
            500                 505                 510         


Asp Arg Leu His Thr Ile Arg His Tyr Gln His Val Leu Ala Val Asp 
        515                 520                 525             


Pro Glu Lys Ala Ala Gln Met Lys Ser Gln Val Met Thr His Leu His 
    530                 535                 540                 


Val Ile Glu Glu Arg Arg Asn Gln Ser Leu Ser Leu Leu Tyr Lys Val 
545                 550                 555                 560 


Pro Tyr Val Ala Gln Glu Ile Gln Glu Glu Ile Asp Glu Leu Leu Gln 
                565                 570                 575     


Glu Gln Arg Ala Asp Met Asp Gln Phe Thr Ala Ser Ile Ser Glu Thr 
            580                 585                 590         


Pro Val Asp Val Arg Val Ser Ser Glu Glu Ser Glu Glu Ile Pro Pro 
        595                 600                 605             


Phe His Pro Phe His Pro Phe Pro Ala Leu Pro Glu Asn Glu Gly Ser 
    610                 615                 620                 


Gly Val Gly Glu Gln Asp Gly Gly Leu Ile Gly Ala Glu Glu Lys Val 
625                 630                 635                 640 


Ile Asn Ser Lys Asn Lys Val Asp Glu Asn Met Val Ile Asp Glu Thr 
                645                 650                 655     


Leu Asp Val Lys Glu Met Ile Phe Asn Ala Glu Arg Val Gly Gly Leu 
            660                 665                 670         


Glu Glu Glu Arg Glu Ser Val Gly Pro Leu Arg Glu Asp Phe Ser Leu 
        675                 680                 685             


Ser Ser Ser Ala Leu Ile Gly Leu Leu Val Ile Ala Val Ala Ile Ala 
    690                 695                 700                 


Thr Val Ile Val Ile Ser Leu Val Met Leu Arg Lys Arg Gln Tyr Gly 
705                 710                 715                 720 


Thr Ile Ser His Gly Ile Val Glu Val Asp Pro Met Leu Thr Pro Glu 
                725                 730                 735     


Glu Arg His Leu Asn Lys Met Gln Asn His Gly Tyr Glu Asn Pro Thr 
            740                 745                 750         


Tyr Lys Tyr Leu Glu Gln Met Gln Ile 
        755                 760     


<210>  929
<211>  267
<212>  PRT
<213>  Homo Sapiens

<400>  929

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 
            260                 265         


<210>  930
<211>  267
<212>  PRT
<213>  Homo Sapiens

<400>  930

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 
            260                 265         


<210>  931
<211>  267
<212>  PRT
<213>  Homo Sapiens

<400>  931

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 
            260                 265         


<210>  932
<211>  267
<212>  PRT
<213>  Homo Sapiens

<400>  932

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 
            260                 265         


<210>  933
<211>  245
<212>  PRT
<213>  Homo Sapiens

<400>  933

Met Ser Gly Gly Ala Arg Gly Phe Cys Met Leu Lys Ala Pro His Ser 
1               5                   10                  15      


Ala Arg Pro Phe Phe Ser Ser Arg Ser Pro Thr Ala Leu Gln Asp Glu 
            20                  25                  30          


Ser Cys Gly Ala Asp Leu Gly Arg Ala Leu Pro Asp Gly Leu Lys Leu 
        35                  40                  45              


Leu Asp Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu 
    50                  55                  60                  


Gln Leu Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu 
65                  70                  75                  80  


Thr Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys 
                85                  90                  95      


Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu 
            100                 105                 110         


Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu 
        115                 120                 125             


Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser 
    130                 135                 140                 


Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala 
145                 150                 155                 160 


Leu Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu 
                165                 170                 175     


Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala 
            180                 185                 190         


Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys 
        195                 200                 205             


Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu 
    210                 215                 220                 


Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys 
225                 230                 235                 240 


Lys Leu Asn Thr Gln 
                245 


<210>  934
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  934

Met Cys Glu Gln His Pro Lys Arg Pro Gly Leu Gln Leu Trp Arg Gly 
1               5                   10                  15      


Arg Glu Pro Gly Trp Asn Gly Gln Gln Ala Ala Leu Pro Thr Val Thr 
            20                  25                  30          


Asn Met Lys Leu Leu Ala Ala Thr Val Leu Leu Leu Thr Ile Cys Ser 
        35                  40                  45              


Leu Glu Gly Ala Leu Val Arg Arg Gln Ala Lys Glu Pro Cys Val Glu 
    50                  55                  60                  


Ser Leu Val Ser Gln Tyr Phe Gln Thr Val Thr Asp Tyr Gly Lys Asp 
65                  70                  75                  80  


Leu Met Glu Lys Val Lys Ser Pro Glu Leu Gln Ala Glu Ala Lys Ser 
                85                  90                  95      


Tyr Phe Glu Lys Ser Lys Glu Gln Leu Thr Pro Leu Ile Lys Lys Ala 
            100                 105                 110         


Gly Thr Glu Leu Val Asn Phe Leu Ser Tyr Phe Val Glu Leu Gly Thr 
        115                 120                 125             


Gln Pro Ala Thr Gln 
    130             


<210>  935
<211>  52
<212>  PRT
<213>  Homo Sapiens

<400>  935

Met Glu Lys Val Lys Ser Pro Glu Leu Gln Ala Glu Ala Lys Ser Tyr 
1               5                   10                  15      


Phe Glu Lys Ser Lys Glu Gln Leu Thr Pro Leu Ile Lys Lys Ala Gly 
            20                  25                  30          


Thr Glu Leu Val Asn Phe Leu Ser Tyr Phe Val Glu Leu Gly Thr Gln 
        35                  40                  45              


Pro Ala Thr Gln 
    50          


<210>  936
<211>  52
<212>  PRT
<213>  Homo Sapiens

<400>  936

Met Glu Lys Val Lys Ser Pro Glu Leu Gln Ala Glu Ala Lys Ser Tyr 
1               5                   10                  15      


Phe Glu Lys Ser Lys Glu Gln Leu Thr Pro Leu Ile Lys Lys Ala Gly 
            20                  25                  30          


Thr Glu Leu Val Asn Phe Leu Ser Tyr Phe Val Glu Leu Gly Thr Gln 
        35                  40                  45              


Pro Ala Thr Gln 
    50          


<210>  937
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  937

Met Lys Leu Leu Ala Ala Thr Val Leu Leu Leu Thr Ile Cys Ser Leu 
1               5                   10                  15      


Glu Gly Ala Leu Val Arg Arg Gln Ala Lys Glu Pro Cys Val Glu Ser 
            20                  25                  30          


Leu Val Ser Gln Tyr Phe Gln Thr Val Thr Asp Tyr Gly Lys Asp Leu 
        35                  40                  45              


Met Glu Lys Val Lys Ser Pro Glu Leu Gln Ala Glu Ala Lys Ser Tyr 
    50                  55                  60                  


Phe Glu 
65      


<210>  938
<211>  95
<212>  PRT
<213>  Homo Sapiens

<400>  938

Met Lys Leu Leu Ala Ala Thr Val Leu Leu Leu Thr Ile Cys Ser Leu 
1               5                   10                  15      


Glu Gly Ala Leu Val Arg Arg Gln Ala Lys Glu Pro Cys Val Glu Ser 
            20                  25                  30          


Leu Val Ser Gln Tyr Phe Gln Thr Val Thr Asp Tyr Gly Lys Asp Leu 
        35                  40                  45              


Met Glu Lys Val Lys Ser Pro Glu Leu Gln Ala Glu Ala Lys Ser Tyr 
    50                  55                  60                  


Phe Glu Lys Ser Lys Glu Gln Leu Thr Pro Leu Ile Lys Lys Ala Gly 
65                  70                  75                  80  


Thr Glu Leu Val Asn Phe Leu Ser Tyr Phe Val Glu Leu Gly Thr 
                85                  90                  95  


<210>  939
<211>  100
<212>  PRT
<213>  Homo Sapiens

<400>  939

Met Lys Leu Leu Ala Ala Thr Val Leu Leu Leu Thr Ile Cys Ser Leu 
1               5                   10                  15      


Glu Gly Ala Leu Val Arg Arg Gln Ala Lys Glu Pro Cys Val Glu Ser 
            20                  25                  30          


Leu Val Ser Gln Tyr Phe Gln Thr Val Thr Asp Tyr Gly Lys Asp Leu 
        35                  40                  45              


Met Glu Lys Val Lys Ser Pro Glu Leu Gln Ala Glu Ala Lys Ser Tyr 
    50                  55                  60                  


Phe Glu Lys Ser Lys Glu Gln Leu Thr Pro Leu Ile Lys Lys Ala Gly 
65                  70                  75                  80  


Thr Glu Leu Val Asn Phe Leu Ser Tyr Phe Val Glu Leu Gly Thr Gln 
                85                  90                  95      


Pro Ala Thr Gln 
            100 


<210>  940
<211>  82
<212>  PRT
<213>  Homo Sapiens

<400>  940

Met Lys Leu Leu Ala Ala Thr Val Leu Leu Leu Thr Ile Cys Ser Leu 
1               5                   10                  15      


Glu Gly Ala Leu Val Arg Arg Gln Ala Lys Glu Pro Cys Val Glu Ser 
            20                  25                  30          


Leu Val Ser Gln Tyr Phe Gln Thr Val Thr Asp Tyr Gly Lys Asp Leu 
        35                  40                  45              


Met Glu Lys Val Lys Ser Pro Glu Leu Gln Ala Glu Ala Lys Ser Tyr 
    50                  55                  60                  


Phe Glu Asn Phe Leu Ser Tyr Phe Val Glu Leu Gly Thr Gln Pro Ala 
65                  70                  75                  80  


Thr Gln 
        


<210>  941
<211>  72
<212>  PRT
<213>  Homo Sapiens

<400>  941

Met Lys Leu Leu Ala Ala Thr Val Leu Leu Leu Thr Ile Cys Ser Leu 
1               5                   10                  15      


Glu Gly Leu Ala Thr Lys Gly Leu Lys Arg Lys Ile Ile Pro Ser Leu 
            20                  25                  30          


Lys Pro Arg Lys Pro Ile Gln Arg Ser Gly Trp Ile Pro Phe Trp Gly 
        35                  40                  45              


Gly Gly Arg Glu Leu Gly Trp Val Leu Ala Glu Val Trp Gln Glu Ala 
    50                  55                  60                  


Arg Ile His Cys Cys Gly Pro Ser 
65                  70          


<210>  942
<211>  27
<212>  PRT
<213>  Homo Sapiens

<400>  942

Met Lys Leu Leu Ala Ala Thr Val Leu Leu Leu Thr Ile Cys Ser Leu 
1               5                   10                  15      


Glu Gly Leu Thr Leu Lys Ser Gln Arg Ser Ser 
            20                  25          


<210>  943
<211>  396
<212>  PRT
<213>  Homo Sapiens

<400>  943

Met Phe Leu Lys Ala Val Val Leu Thr Leu Ala Leu Val Ala Val Ala 
1               5                   10                  15      


Gly Ala Arg Ala Glu Val Ser Ala Asp Gln Val Ala Thr Val Met Trp 
            20                  25                  30          


Asp Tyr Phe Ser Gln Leu Ser Asn Asn Ala Lys Glu Ala Val Glu His 
        35                  40                  45              


Leu Gln Lys Ser Glu Leu Thr Gln Gln Leu Asn Ala Leu Phe Gln Asp 
    50                  55                  60                  


Lys Leu Gly Glu Val Asn Thr Tyr Ala Gly Asp Leu Gln Lys Lys Leu 
65                  70                  75                  80  


Val Pro Phe Ala Thr Glu Leu His Glu Arg Leu Ala Lys Asp Ser Glu 
                85                  90                  95      


Lys Leu Lys Glu Glu Ile Gly Lys Glu Leu Glu Glu Leu Arg Ala Arg 
            100                 105                 110         


Leu Leu Pro His Ala Asn Glu Val Ser Gln Lys Ile Gly Asp Asn Leu 
        115                 120                 125             


Arg Glu Leu Gln Gln Arg Leu Glu Pro Tyr Ala Asp Gln Leu Arg Thr 
    130                 135                 140                 


Gln Val Ser Thr Gln Ala Glu Gln Leu Arg Arg Gln Leu Thr Pro Tyr 
145                 150                 155                 160 


Ala Gln Arg Met Glu Arg Val Leu Arg Glu Asn Ala Asp Ser Leu Gln 
                165                 170                 175     


Ala Ser Leu Arg Pro His Ala Asp Glu Leu Lys Ala Lys Ile Asp Gln 
            180                 185                 190         


Asn Val Glu Glu Leu Lys Gly Arg Leu Thr Pro Tyr Ala Asp Glu Phe 
        195                 200                 205             


Lys Val Lys Ile Asp Gln Thr Val Glu Glu Leu Arg Arg Ser Leu Ala 
    210                 215                 220                 


Pro Tyr Ala Gln Asp Thr Gln Glu Lys Leu Asn His Gln Leu Glu Gly 
225                 230                 235                 240 


Leu Thr Phe Gln Met Lys Lys Asn Ala Glu Glu Leu Lys Ala Arg Ile 
                245                 250                 255     


Ser Ala Ser Ala Glu Glu Leu Arg Gln Arg Leu Ala Pro Leu Ala Glu 
            260                 265                 270         


Asp Val Arg Gly Asn Leu Arg Gly Asn Thr Glu Gly Leu Gln Lys Ser 
        275                 280                 285             


Leu Ala Glu Leu Gly Gly His Leu Asp Gln Gln Val Glu Glu Phe Arg 
    290                 295                 300                 


Arg Arg Val Glu Pro Tyr Gly Glu Asn Phe Asn Lys Ala Leu Val Gln 
305                 310                 315                 320 


Gln Met Glu Gln Leu Arg Gln Lys Leu Gly Pro His Ala Gly Asp Val 
                325                 330                 335     


Glu Gly His Leu Ser Phe Leu Glu Lys Asp Leu Arg Asp Lys Val Asn 
            340                 345                 350         


Ser Phe Phe Ser Thr Phe Lys Glu Lys Glu Ser Gln Asp Lys Thr Leu 
        355                 360                 365             


Ser Leu Pro Glu Leu Glu Gln Gln Gln Glu Gln Gln Gln Glu Gln Gln 
    370                 375                 380                 


Gln Glu Gln Val Gln Met Leu Ala Pro Leu Glu Ser 
385                 390                 395     


<210>  944
<211>  162
<212>  PRT
<213>  Homo Sapiens

<400>  944

Met Ala Ser Met Ala Ala Val Leu Thr Trp Ala Leu Ala Leu Leu Ser 
1               5                   10                  15      


Ala Phe Ser Ala Thr Gln Ala Arg Lys Gly Phe Trp Asp Tyr Phe Ser 
            20                  25                  30          


Gln Thr Ser Gly Asp Lys Gly Arg Val Glu Gln Ile His Gln Gln Lys 
        35                  40                  45              


Met Ala Arg Glu Pro Ala Thr Leu Lys Asp Ser Leu Glu Gln Asp Leu 
    50                  55                  60                  


Asn Asn Met Asn Lys Phe Leu Glu Lys Leu Arg Pro Leu Ser Gly Ser 
65                  70                  75                  80  


Glu Ala Pro Arg Leu Pro Gln Asp Pro Val Gly Met Arg Arg Gln Leu 
                85                  90                  95      


Gln Glu Glu Leu Glu Glu Val Lys Ala Arg Leu Gln Pro Tyr Met Ala 
            100                 105                 110         


Glu Ala His Glu Leu Val Gly Trp Asn Leu Glu Gly Leu Arg Gln Gln 
        115                 120                 125             


Leu Lys Pro Tyr Thr Met Asp Leu Met Glu Gln Val Ala Leu Arg Val 
    130                 135                 140                 


Gln Glu Leu Gln Glu Gln Leu Arg Val Val Gly Glu Asp Thr Lys Ala 
145                 150                 155                 160 


Gln Leu 
        


<210>  945
<211>  366
<212>  PRT
<213>  Homo Sapiens

<400>  945

Met Ala Ser Met Ala Ala Val Leu Thr Trp Ala Leu Ala Leu Leu Ser 
1               5                   10                  15      


Ala Phe Ser Ala Thr Gln Ala Arg Lys Gly Phe Trp Asp Tyr Phe Ser 
            20                  25                  30          


Gln Thr Ser Gly Asp Lys Gly Arg Val Glu Gln Ile His Gln Gln Lys 
        35                  40                  45              


Met Ala Arg Glu Pro Ala Thr Leu Lys Asp Ser Leu Glu Gln Asp Leu 
    50                  55                  60                  


Asn Asn Met Asn Lys Phe Leu Glu Lys Leu Arg Pro Leu Ser Gly Ser 
65                  70                  75                  80  


Glu Ala Pro Arg Leu Pro Gln Asp Pro Val Gly Met Arg Arg Gln Leu 
                85                  90                  95      


Gln Glu Glu Leu Glu Glu Val Lys Ala Arg Leu Gln Pro Tyr Met Ala 
            100                 105                 110         


Glu Ala His Glu Leu Val Gly Trp Asn Leu Glu Gly Leu Arg Gln Gln 
        115                 120                 125             


Leu Lys Pro Tyr Thr Met Asp Leu Met Glu Gln Val Ala Leu Arg Val 
    130                 135                 140                 


Gln Glu Leu Gln Glu Gln Leu Arg Val Val Gly Glu Asp Thr Lys Ala 
145                 150                 155                 160 


Gln Leu Leu Gly Gly Val Asp Glu Ala Trp Ala Leu Leu Gln Gly Leu 
                165                 170                 175     


Gln Ser Arg Val Val His His Thr Gly Arg Phe Lys Glu Leu Phe His 
            180                 185                 190         


Pro Tyr Ala Glu Ser Leu Val Ser Gly Ile Gly Arg His Val Gln Glu 
        195                 200                 205             


Leu His Arg Ser Val Ala Pro His Ala Pro Ala Ser Pro Ala Arg Leu 
    210                 215                 220                 


Ser Arg Cys Val Gln Val Leu Ser Arg Lys Leu Thr Leu Lys Ala Lys 
225                 230                 235                 240 


Ala Leu His Ala Arg Ile Gln Gln Asn Leu Asp Gln Leu Arg Glu Glu 
                245                 250                 255     


Leu Ser Arg Ala Phe Ala Gly Thr Gly Thr Glu Glu Gly Ala Gly Pro 
            260                 265                 270         


Asp Pro Gln Met Leu Ser Glu Glu Val Arg Gln Arg Leu Gln Ala Phe 
        275                 280                 285             


Arg Gln Asp Thr Tyr Leu Gln Ile Ala Ala Phe Thr Arg Ala Ile Asp 
    290                 295                 300                 


Gln Glu Thr Glu Glu Val Gln Gln Gln Leu Ala Pro Pro Pro Pro Gly 
305                 310                 315                 320 


His Ser Ala Phe Ala Pro Glu Phe Gln Gln Thr Asp Ser Gly Lys Val 
                325                 330                 335     


Leu Ser Lys Leu Gln Ala Arg Leu Asp Asp Leu Trp Glu Asp Ile Thr 
            340                 345                 350         


His Ser Leu His Asp Gln Gly His Ser His Leu Gly Asp Pro 
        355                 360                 365     


<210>  946
<211>  366
<212>  PRT
<213>  Homo Sapiens

<400>  946

Met Ala Ser Met Ala Ala Val Leu Thr Trp Ala Leu Ala Leu Leu Ser 
1               5                   10                  15      


Ala Phe Ser Ala Thr Gln Ala Arg Lys Gly Phe Trp Asp Tyr Phe Ser 
            20                  25                  30          


Gln Thr Ser Gly Asp Lys Gly Arg Val Glu Gln Ile His Gln Gln Lys 
        35                  40                  45              


Met Ala Arg Glu Pro Ala Thr Leu Lys Asp Ser Leu Glu Gln Asp Leu 
    50                  55                  60                  


Asn Asn Met Asn Lys Phe Leu Glu Lys Leu Arg Pro Leu Ser Gly Ser 
65                  70                  75                  80  


Glu Ala Pro Arg Leu Pro Gln Asp Pro Val Gly Met Arg Arg Gln Leu 
                85                  90                  95      


Gln Glu Glu Leu Glu Glu Val Lys Ala Arg Leu Gln Pro Tyr Met Ala 
            100                 105                 110         


Glu Ala His Glu Leu Val Gly Trp Asn Leu Glu Gly Leu Arg Gln Gln 
        115                 120                 125             


Leu Lys Pro Tyr Thr Met Asp Leu Met Glu Gln Val Ala Leu Arg Val 
    130                 135                 140                 


Gln Glu Leu Gln Glu Gln Leu Arg Val Val Gly Glu Asp Thr Lys Ala 
145                 150                 155                 160 


Gln Leu Leu Gly Gly Val Asp Glu Ala Trp Ala Leu Leu Gln Gly Leu 
                165                 170                 175     


Gln Ser Arg Val Val His His Thr Gly Arg Phe Lys Glu Leu Phe His 
            180                 185                 190         


Pro Tyr Ala Glu Ser Leu Val Ser Gly Ile Gly Arg His Val Gln Glu 
        195                 200                 205             


Leu His Arg Ser Val Ala Pro His Ala Pro Ala Ser Pro Ala Arg Leu 
    210                 215                 220                 


Ser Arg Cys Val Gln Val Leu Ser Arg Lys Leu Thr Leu Lys Ala Lys 
225                 230                 235                 240 


Ala Leu His Ala Arg Ile Gln Gln Asn Leu Asp Gln Leu Arg Glu Glu 
                245                 250                 255     


Leu Ser Arg Ala Phe Ala Gly Thr Gly Thr Glu Glu Gly Ala Gly Pro 
            260                 265                 270         


Asp Pro Gln Met Leu Ser Glu Glu Val Arg Gln Arg Leu Gln Ala Phe 
        275                 280                 285             


Arg Gln Asp Thr Tyr Leu Gln Ile Ala Ala Phe Thr Arg Ala Ile Asp 
    290                 295                 300                 


Gln Glu Thr Glu Glu Val Gln Gln Gln Leu Ala Pro Pro Pro Pro Gly 
305                 310                 315                 320 


His Ser Ala Phe Ala Pro Glu Phe Gln Gln Thr Asp Ser Gly Lys Val 
                325                 330                 335     


Leu Ser Lys Leu Gln Ala Arg Leu Asp Asp Leu Trp Glu Asp Ile Thr 
            340                 345                 350         


His Ser Leu His Asp Gln Gly His Ser His Leu Gly Asp Pro 
        355                 360                 365     


<210>  947
<211>  4563
<212>  PRT
<213>  Homo Sapiens

<400>  947

Met Asp Pro Pro Arg Pro Ala Leu Leu Ala Leu Leu Ala Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Ala Gly Ala Arg Ala Glu Glu Glu Met Leu 
            20                  25                  30          


Glu Asn Val Ser Leu Val Cys Pro Lys Asp Ala Thr Arg Phe Lys His 
        35                  40                  45              


Leu Arg Lys Tyr Thr Tyr Asn Tyr Glu Ala Glu Ser Ser Ser Gly Val 
    50                  55                  60                  


Pro Gly Thr Ala Asp Ser Arg Ser Ala Thr Arg Ile Asn Cys Lys Val 
65                  70                  75                  80  


Glu Leu Glu Val Pro Gln Leu Cys Ser Phe Ile Leu Lys Thr Ser Gln 
                85                  90                  95      


Cys Thr Leu Lys Glu Val Tyr Gly Phe Asn Pro Glu Gly Lys Ala Leu 
            100                 105                 110         


Leu Lys Lys Thr Lys Asn Ser Glu Glu Phe Ala Ala Ala Met Ser Arg 
        115                 120                 125             


Tyr Glu Leu Lys Leu Ala Ile Pro Glu Gly Lys Gln Val Phe Leu Tyr 
    130                 135                 140                 


Pro Glu Lys Asp Glu Pro Thr Tyr Ile Leu Asn Ile Lys Arg Gly Ile 
145                 150                 155                 160 


Ile Ser Ala Leu Leu Val Pro Pro Glu Thr Glu Glu Ala Lys Gln Val 
                165                 170                 175     


Leu Phe Leu Asp Thr Val Tyr Gly Asn Cys Ser Thr His Phe Thr Val 
            180                 185                 190         


Lys Thr Arg Lys Gly Asn Val Ala Thr Glu Ile Ser Thr Glu Arg Asp 
        195                 200                 205             


Leu Gly Gln Cys Asp Arg Phe Lys Pro Ile Arg Thr Gly Ile Ser Pro 
    210                 215                 220                 


Leu Ala Leu Ile Lys Gly Met Thr Arg Pro Leu Ser Thr Leu Ile Ser 
225                 230                 235                 240 


Ser Ser Gln Ser Cys Gln Tyr Thr Leu Asp Ala Lys Arg Lys His Val 
                245                 250                 255     


Ala Glu Ala Ile Cys Lys Glu Gln His Leu Phe Leu Pro Phe Ser Tyr 
            260                 265                 270         


Lys Asn Lys Tyr Gly Met Val Ala Gln Val Thr Gln Thr Leu Lys Leu 
        275                 280                 285             


Glu Asp Thr Pro Lys Ile Asn Ser Arg Phe Phe Gly Glu Gly Thr Lys 
    290                 295                 300                 


Lys Met Gly Leu Ala Phe Glu Ser Thr Lys Ser Thr Ser Pro Pro Lys 
305                 310                 315                 320 


Gln Ala Glu Ala Val Leu Lys Thr Leu Gln Glu Leu Lys Lys Leu Thr 
                325                 330                 335     


Ile Ser Glu Gln Asn Ile Gln Arg Ala Asn Leu Phe Asn Lys Leu Val 
            340                 345                 350         


Thr Glu Leu Arg Gly Leu Ser Asp Glu Ala Val Thr Ser Leu Leu Pro 
        355                 360                 365             


Gln Leu Ile Glu Val Ser Ser Pro Ile Thr Leu Gln Ala Leu Val Gln 
    370                 375                 380                 


Cys Gly Gln Pro Gln Cys Ser Thr His Ile Leu Gln Trp Leu Lys Arg 
385                 390                 395                 400 


Val His Ala Asn Pro Leu Leu Ile Asp Val Val Thr Tyr Leu Val Ala 
                405                 410                 415     


Leu Ile Pro Glu Pro Ser Ala Gln Gln Leu Arg Glu Ile Phe Asn Met 
            420                 425                 430         


Ala Arg Asp Gln Arg Ser Arg Ala Thr Leu Tyr Ala Leu Ser His Ala 
        435                 440                 445             


Val Asn Asn Tyr His Lys Thr Asn Pro Thr Gly Thr Gln Glu Leu Leu 
    450                 455                 460                 


Asp Ile Ala Asn Tyr Leu Met Glu Gln Ile Gln Asp Asp Cys Thr Gly 
465                 470                 475                 480 


Asp Glu Asp Tyr Thr Tyr Leu Ile Leu Arg Val Ile Gly Asn Met Gly 
                485                 490                 495     


Gln Thr Met Glu Gln Leu Thr Pro Glu Leu Lys Ser Ser Ile Leu Lys 
            500                 505                 510         


Cys Val Gln Ser Thr Lys Pro Ser Leu Met Ile Gln Lys Ala Ala Ile 
        515                 520                 525             


Gln Ala Leu Arg Lys Met Glu Pro Lys Asp Lys Asp Gln Glu Val Leu 
    530                 535                 540                 


Leu Gln Thr Phe Leu Asp Asp Ala Ser Pro Gly Asp Lys Arg Leu Ala 
545                 550                 555                 560 


Ala Tyr Leu Met Leu Met Arg Ser Pro Ser Gln Ala Asp Ile Asn Lys 
                565                 570                 575     


Ile Val Gln Ile Leu Pro Trp Glu Gln Asn Glu Gln Val Lys Asn Phe 
            580                 585                 590         


Val Ala Ser His Ile Ala Asn Ile Leu Asn Ser Glu Glu Leu Asp Ile 
        595                 600                 605             


Gln Asp Leu Lys Lys Leu Val Lys Glu Ala Leu Lys Glu Ser Gln Leu 
    610                 615                 620                 


Pro Thr Val Met Asp Phe Arg Lys Phe Ser Arg Asn Tyr Gln Leu Tyr 
625                 630                 635                 640 


Lys Ser Val Ser Leu Pro Ser Leu Asp Pro Ala Ser Ala Lys Ile Glu 
                645                 650                 655     


Gly Asn Leu Ile Phe Asp Pro Asn Asn Tyr Leu Pro Lys Glu Ser Met 
            660                 665                 670         


Leu Lys Thr Thr Leu Thr Ala Phe Gly Phe Ala Ser Ala Asp Leu Ile 
        675                 680                 685             


Glu Ile Gly Leu Glu Gly Lys Gly Phe Glu Pro Thr Leu Glu Ala Leu 
    690                 695                 700                 


Phe Gly Lys Gln Gly Phe Phe Pro Asp Ser Val Asn Lys Ala Leu Tyr 
705                 710                 715                 720 


Trp Val Asn Gly Gln Val Pro Asp Gly Val Ser Lys Val Leu Val Asp 
                725                 730                 735     


His Phe Gly Tyr Thr Lys Asp Asp Lys His Glu Gln Asp Met Val Asn 
            740                 745                 750         


Gly Ile Met Leu Ser Val Glu Lys Leu Ile Lys Asp Leu Lys Ser Lys 
        755                 760                 765             


Glu Val Pro Glu Ala Arg Ala Tyr Leu Arg Ile Leu Gly Glu Glu Leu 
    770                 775                 780                 


Gly Phe Ala Ser Leu His Asp Leu Gln Leu Leu Gly Lys Leu Leu Leu 
785                 790                 795                 800 


Met Gly Ala Arg Thr Leu Gln Gly Ile Pro Gln Met Ile Gly Glu Val 
                805                 810                 815     


Ile Arg Lys Gly Ser Lys Asn Asp Phe Phe Leu His Tyr Ile Phe Met 
            820                 825                 830         


Glu Asn Ala Phe Glu Leu Pro Thr Gly Ala Gly Leu Gln Leu Gln Ile 
        835                 840                 845             


Ser Ser Ser Gly Val Ile Ala Pro Gly Ala Lys Ala Gly Val Lys Leu 
    850                 855                 860                 


Glu Val Ala Asn Met Gln Ala Glu Leu Val Ala Lys Pro Ser Val Ser 
865                 870                 875                 880 


Val Glu Phe Val Thr Asn Met Gly Ile Ile Ile Pro Asp Phe Ala Arg 
                885                 890                 895     


Ser Gly Val Gln Met Asn Thr Asn Phe Phe His Glu Ser Gly Leu Glu 
            900                 905                 910         


Ala His Val Ala Leu Lys Ala Gly Lys Leu Lys Phe Ile Ile Pro Ser 
        915                 920                 925             


Pro Lys Arg Pro Val Lys Leu Leu Ser Gly Gly Asn Thr Leu His Leu 
    930                 935                 940                 


Val Ser Thr Thr Lys Thr Glu Val Ile Pro Pro Leu Ile Glu Asn Arg 
945                 950                 955                 960 


Gln Ser Trp Ser Val Cys Lys Gln Val Phe Pro Gly Leu Asn Tyr Cys 
                965                 970                 975     


Thr Ser Gly Ala Tyr Ser Asn Ala Ser Ser Thr Asp Ser Ala Ser Tyr 
            980                 985                 990         


Tyr Pro Leu Thr Gly Asp Thr Arg  Leu Glu Leu Glu Leu  Arg Pro Thr 
        995                 1000                 1005             


Gly Glu  Ile Glu Gln Tyr Ser  Val Ser Ala Thr Tyr  Glu Leu Gln 
    1010                 1015                 1020             


Arg Glu  Asp Arg Ala Leu Val  Asp Thr Leu Lys Phe  Val Thr Gln 
    1025                 1030                 1035             


Ala Glu  Gly Ala Lys Gln Thr  Glu Ala Thr Met Thr  Phe Lys Tyr 
    1040                 1045                 1050             


Asn Arg  Gln Ser Met Thr Leu  Ser Ser Glu Val Gln  Ile Pro Asp 
    1055                 1060                 1065             


Phe Asp  Val Asp Leu Gly Thr  Ile Leu Arg Val Asn  Asp Glu Ser 
    1070                 1075                 1080             


Thr Glu  Gly Lys Thr Ser Tyr  Arg Leu Thr Leu Asp  Ile Gln Asn 
    1085                 1090                 1095             


Lys Lys  Ile Thr Glu Val Ala  Leu Met Gly His Leu  Ser Cys Asp 
    1100                 1105                 1110             


Thr Lys  Glu Glu Arg Lys Ile  Lys Gly Val Ile Ser  Ile Pro Arg 
    1115                 1120                 1125             


Leu Gln  Ala Glu Ala Arg Ser  Glu Ile Leu Ala His  Trp Ser Pro 
    1130                 1135                 1140             


Ala Lys  Leu Leu Leu Gln Met  Asp Ser Ser Ala Thr  Ala Tyr Gly 
    1145                 1150                 1155             


Ser Thr  Val Ser Lys Arg Val  Ala Trp His Tyr Asp  Glu Glu Lys 
    1160                 1165                 1170             


Ile Glu  Phe Glu Trp Asn Thr  Gly Thr Asn Val Asp  Thr Lys Lys 
    1175                 1180                 1185             


Met Thr  Ser Asn Phe Pro Val  Asp Leu Ser Asp Tyr  Pro Lys Ser 
    1190                 1195                 1200             


Leu His  Met Tyr Ala Asn Arg  Leu Leu Asp His Arg  Val Pro Gln 
    1205                 1210                 1215             


Thr Asp  Met Thr Phe Arg His  Val Gly Ser Lys Leu  Ile Val Ala 
    1220                 1225                 1230             


Met Ser  Ser Trp Leu Gln Lys  Ala Ser Gly Ser Leu  Pro Tyr Thr 
    1235                 1240                 1245             


Gln Thr  Leu Gln Asp His Leu  Asn Ser Leu Lys Glu  Phe Asn Leu 
    1250                 1255                 1260             


Gln Asn  Met Gly Leu Pro Asp  Phe His Ile Pro Glu  Asn Leu Phe 
    1265                 1270                 1275             


Leu Lys  Ser Asp Gly Arg Val  Lys Tyr Thr Leu Asn  Lys Asn Ser 
    1280                 1285                 1290             


Leu Lys  Ile Glu Ile Pro Leu  Pro Phe Gly Gly Lys  Ser Ser Arg 
    1295                 1300                 1305             


Asp Leu  Lys Met Leu Glu Thr  Val Arg Thr Pro Ala  Leu His Phe 
    1310                 1315                 1320             


Lys Ser  Val Gly Phe His Leu  Pro Ser Arg Glu Phe  Gln Val Pro 
    1325                 1330                 1335             


Thr Phe  Thr Ile Pro Lys Leu  Tyr Gln Leu Gln Val  Pro Leu Leu 
    1340                 1345                 1350             


Gly Val  Leu Asp Leu Ser Thr  Asn Val Tyr Ser Asn  Leu Tyr Asn 
    1355                 1360                 1365             


Trp Ser  Ala Ser Tyr Ser Gly  Gly Asn Thr Ser Thr  Asp His Phe 
    1370                 1375                 1380             


Ser Leu  Arg Ala Arg Tyr His  Met Lys Ala Asp Ser  Val Val Asp 
    1385                 1390                 1395             


Leu Leu  Ser Tyr Asn Val Gln  Gly Ser Gly Glu Thr  Thr Tyr Asp 
    1400                 1405                 1410             


His Lys  Asn Thr Phe Thr Leu  Ser Cys Asp Gly Ser  Leu Arg His 
    1415                 1420                 1425             


Lys Phe  Leu Asp Ser Asn Ile  Lys Phe Ser His Val  Glu Lys Leu 
    1430                 1435                 1440             


Gly Asn  Asn Pro Val Ser Lys  Gly Leu Leu Ile Phe  Asp Ala Ser 
    1445                 1450                 1455             


Ser Ser  Trp Gly Pro Gln Met  Ser Ala Ser Val His  Leu Asp Ser 
    1460                 1465                 1470             


Lys Lys  Lys Gln His Leu Phe  Val Lys Glu Val Lys  Ile Asp Gly 
    1475                 1480                 1485             


Gln Phe  Arg Val Ser Ser Phe  Tyr Ala Lys Gly Thr  Tyr Gly Leu 
    1490                 1495                 1500             


Ser Cys  Gln Arg Asp Pro Asn  Thr Gly Arg Leu Asn  Gly Glu Ser 
    1505                 1510                 1515             


Asn Leu  Arg Phe Asn Ser Ser  Tyr Leu Gln Gly Thr  Asn Gln Ile 
    1520                 1525                 1530             


Thr Gly  Arg Tyr Glu Asp Gly  Thr Leu Ser Leu Thr  Ser Thr Ser 
    1535                 1540                 1545             


Asp Leu  Gln Ser Gly Ile Ile  Lys Asn Thr Ala Ser  Leu Lys Tyr 
    1550                 1555                 1560             


Glu Asn  Tyr Glu Leu Thr Leu  Lys Ser Asp Thr Asn  Gly Lys Tyr 
    1565                 1570                 1575             


Lys Asn  Phe Ala Thr Ser Asn  Lys Met Asp Met Thr  Phe Ser Lys 
    1580                 1585                 1590             


Gln Asn  Ala Leu Leu Arg Ser  Glu Tyr Gln Ala Asp  Tyr Glu Ser 
    1595                 1600                 1605             


Leu Arg  Phe Phe Ser Leu Leu  Ser Gly Ser Leu Asn  Ser His Gly 
    1610                 1615                 1620             


Leu Glu  Leu Asn Ala Asp Ile  Leu Gly Thr Asp Lys  Ile Asn Ser 
    1625                 1630                 1635             


Gly Ala  His Lys Ala Thr Leu  Arg Ile Gly Gln Asp  Gly Ile Ser 
    1640                 1645                 1650             


Thr Ser  Ala Thr Thr Asn Leu  Lys Cys Ser Leu Leu  Val Leu Glu 
    1655                 1660                 1665             


Asn Glu  Leu Asn Ala Glu Leu  Gly Leu Ser Gly Ala  Ser Met Lys 
    1670                 1675                 1680             


Leu Thr  Thr Asn Gly Arg Phe  Arg Glu His Asn Ala  Lys Phe Ser 
    1685                 1690                 1695             


Leu Asp  Gly Lys Ala Ala Leu  Thr Glu Leu Ser Leu  Gly Ser Ala 
    1700                 1705                 1710             


Tyr Gln  Ala Met Ile Leu Gly  Val Asp Ser Lys Asn  Ile Phe Asn 
    1715                 1720                 1725             


Phe Lys  Val Ser Gln Glu Gly  Leu Lys Leu Ser Asn  Asp Met Met 
    1730                 1735                 1740             


Gly Ser  Tyr Ala Glu Met Lys  Phe Asp His Thr Asn  Ser Leu Asn 
    1745                 1750                 1755             


Ile Ala  Gly Leu Ser Leu Asp  Phe Ser Ser Lys Leu  Asp Asn Ile 
    1760                 1765                 1770             


Tyr Ser  Ser Asp Lys Phe Tyr  Lys Gln Thr Val Asn  Leu Gln Leu 
    1775                 1780                 1785             


Gln Pro  Tyr Ser Leu Val Thr  Thr Leu Asn Ser Asp  Leu Lys Tyr 
    1790                 1795                 1800             


Asn Ala  Leu Asp Leu Thr Asn  Asn Gly Lys Leu Arg  Leu Glu Pro 
    1805                 1810                 1815             


Leu Lys  Leu His Val Ala Gly  Asn Leu Lys Gly Ala  Tyr Gln Asn 
    1820                 1825                 1830             


Asn Glu  Ile Lys His Ile Tyr  Ala Ile Ser Ser Ala  Ala Leu Ser 
    1835                 1840                 1845             


Ala Ser  Tyr Lys Ala Asp Thr  Val Ala Lys Val Gln  Gly Val Glu 
    1850                 1855                 1860             


Phe Ser  His Arg Leu Asn Thr  Asp Ile Ala Gly Leu  Ala Ser Ala 
    1865                 1870                 1875             


Ile Asp  Met Ser Thr Asn Tyr  Asn Ser Asp Ser Leu  His Phe Ser 
    1880                 1885                 1890             


Asn Val  Phe Arg Ser Val Met  Ala Pro Phe Thr Met  Thr Ile Asp 
    1895                 1900                 1905             


Ala His  Thr Asn Gly Asn Gly  Lys Leu Ala Leu Trp  Gly Glu His 
    1910                 1915                 1920             


Thr Gly  Gln Leu Tyr Ser Lys  Phe Leu Leu Lys Ala  Glu Pro Leu 
    1925                 1930                 1935             


Ala Phe  Thr Phe Ser His Asp  Tyr Lys Gly Ser Thr  Ser His His 
    1940                 1945                 1950             


Leu Val  Ser Arg Lys Ser Ile  Ser Ala Ala Leu Glu  His Lys Val 
    1955                 1960                 1965             


Ser Ala  Leu Leu Thr Pro Ala  Glu Gln Thr Gly Thr  Trp Lys Leu 
    1970                 1975                 1980             


Lys Thr  Gln Phe Asn Asn Asn  Glu Tyr Ser Gln Asp  Leu Asp Ala 
    1985                 1990                 1995             


Tyr Asn  Thr Lys Asp Lys Ile  Gly Val Glu Leu Thr  Gly Arg Thr 
    2000                 2005                 2010             


Leu Ala  Asp Leu Thr Leu Leu  Asp Ser Pro Ile Lys  Val Pro Leu 
    2015                 2020                 2025             


Leu Leu  Ser Glu Pro Ile Asn  Ile Ile Asp Ala Leu  Glu Met Arg 
    2030                 2035                 2040             


Asp Ala  Val Glu Lys Pro Gln  Glu Phe Thr Ile Val  Ala Phe Val 
    2045                 2050                 2055             


Lys Tyr  Asp Lys Asn Gln Asp  Val His Ser Ile Asn  Leu Pro Phe 
    2060                 2065                 2070             


Phe Glu  Thr Leu Gln Glu Tyr  Phe Glu Arg Asn Arg  Gln Thr Ile 
    2075                 2080                 2085             


Ile Val  Val Leu Glu Asn Val  Gln Arg Asn Leu Lys  His Ile Asn 
    2090                 2095                 2100             


Ile Asp  Gln Phe Val Arg Lys  Tyr Arg Ala Ala Leu  Gly Lys Leu 
    2105                 2110                 2115             


Pro Gln  Gln Ala Asn Asp Tyr  Leu Asn Ser Phe Asn  Trp Glu Arg 
    2120                 2125                 2130             


Gln Val  Ser His Ala Lys Glu  Lys Leu Thr Ala Leu  Thr Lys Lys 
    2135                 2140                 2145             


Tyr Arg  Ile Thr Glu Asn Asp  Ile Gln Ile Ala Leu  Asp Asp Ala 
    2150                 2155                 2160             


Lys Ile  Asn Phe Asn Glu Lys  Leu Ser Gln Leu Gln  Thr Tyr Met 
    2165                 2170                 2175             


Ile Gln  Phe Asp Gln Tyr Ile  Lys Asp Ser Tyr Asp  Leu His Asp 
    2180                 2185                 2190             


Leu Lys  Ile Ala Ile Ala Asn  Ile Ile Asp Glu Ile  Ile Glu Lys 
    2195                 2200                 2205             


Leu Lys  Ser Leu Asp Glu His  Tyr His Ile Arg Val  Asn Leu Val 
    2210                 2215                 2220             


Lys Thr  Ile His Asp Leu His  Leu Phe Ile Glu Asn  Ile Asp Phe 
    2225                 2230                 2235             


Asn Lys  Ser Gly Ser Ser Thr  Ala Ser Trp Ile Gln  Asn Val Asp 
    2240                 2245                 2250             


Thr Lys  Tyr Gln Ile Arg Ile  Gln Ile Gln Glu Lys  Leu Gln Gln 
    2255                 2260                 2265             


Leu Lys  Arg His Ile Gln Asn  Ile Asp Ile Gln His  Leu Ala Gly 
    2270                 2275                 2280             


Lys Leu  Lys Gln His Ile Glu  Ala Ile Asp Val Arg  Val Leu Leu 
    2285                 2290                 2295             


Asp Gln  Leu Gly Thr Thr Ile  Ser Phe Glu Arg Ile  Asn Asp Ile 
    2300                 2305                 2310             


Leu Glu  His Val Lys His Phe  Val Ile Asn Leu Ile  Gly Asp Phe 
    2315                 2320                 2325             


Glu Val  Ala Glu Lys Ile Asn  Ala Phe Arg Ala Lys  Val His Glu 
    2330                 2335                 2340             


Leu Ile  Glu Arg Tyr Glu Val  Asp Gln Gln Ile Gln  Val Leu Met 
    2345                 2350                 2355             


Asp Lys  Leu Val Glu Leu Ala  His Gln Tyr Lys Leu  Lys Glu Thr 
    2360                 2365                 2370             


Ile Gln  Lys Leu Ser Asn Val  Leu Gln Gln Val Lys  Ile Lys Asp 
    2375                 2380                 2385             


Tyr Phe  Glu Lys Leu Val Gly  Phe Ile Asp Asp Ala  Val Lys Lys 
    2390                 2395                 2400             


Leu Asn  Glu Leu Ser Phe Lys  Thr Phe Ile Glu Asp  Val Asn Lys 
    2405                 2410                 2415             


Phe Leu  Asp Met Leu Ile Lys  Lys Leu Lys Ser Phe  Asp Tyr His 
    2420                 2425                 2430             


Gln Phe  Val Asp Glu Thr Asn  Asp Lys Ile Arg Glu  Val Thr Gln 
    2435                 2440                 2445             


Arg Leu  Asn Gly Glu Ile Gln  Ala Leu Glu Leu Pro  Gln Lys Ala 
    2450                 2455                 2460             


Glu Ala  Leu Lys Leu Phe Leu  Glu Glu Thr Lys Ala  Thr Val Ala 
    2465                 2470                 2475             


Val Tyr  Leu Glu Ser Leu Gln  Asp Thr Lys Ile Thr  Leu Ile Ile 
    2480                 2485                 2490             


Asn Trp  Leu Gln Glu Ala Leu  Ser Ser Ala Ser Leu  Ala His Met 
    2495                 2500                 2505             


Lys Ala  Lys Phe Arg Glu Thr  Leu Glu Asp Thr Arg  Asp Arg Met 
    2510                 2515                 2520             


Tyr Gln  Met Asp Ile Gln Gln  Glu Leu Gln Arg Tyr  Leu Ser Leu 
    2525                 2530                 2535             


Val Gly  Gln Val Tyr Ser Thr  Leu Val Thr Tyr Ile  Ser Asp Trp 
    2540                 2545                 2550             


Trp Thr  Leu Ala Ala Lys Asn  Leu Thr Asp Phe Ala  Glu Gln Tyr 
    2555                 2560                 2565             


Ser Ile  Gln Asp Trp Ala Lys  Arg Met Lys Ala Leu  Val Glu Gln 
    2570                 2575                 2580             


Gly Phe  Thr Val Pro Glu Ile  Lys Thr Ile Leu Gly  Thr Met Pro 
    2585                 2590                 2595             


Ala Phe  Glu Val Ser Leu Gln  Ala Leu Gln Lys Ala  Thr Phe Gln 
    2600                 2605                 2610             


Thr Pro  Asp Phe Ile Val Pro  Leu Thr Asp Leu Arg  Ile Pro Ser 
    2615                 2620                 2625             


Val Gln  Ile Asn Phe Lys Asp  Leu Lys Asn Ile Lys  Ile Pro Ser 
    2630                 2635                 2640             


Arg Phe  Ser Thr Pro Glu Phe  Thr Ile Leu Asn Thr  Phe His Ile 
    2645                 2650                 2655             


Pro Ser  Phe Thr Ile Asp Phe  Val Glu Met Lys Val  Lys Ile Ile 
    2660                 2665                 2670             


Arg Thr  Ile Asp Gln Met Leu  Asn Ser Glu Leu Gln  Trp Pro Val 
    2675                 2680                 2685             


Pro Asp  Ile Tyr Leu Arg Asp  Leu Lys Val Glu Asp  Ile Pro Leu 
    2690                 2695                 2700             


Ala Arg  Ile Thr Leu Pro Asp  Phe Arg Leu Pro Glu  Ile Ala Ile 
    2705                 2710                 2715             


Pro Glu  Phe Ile Ile Pro Thr  Leu Asn Leu Asn Asp  Phe Gln Val 
    2720                 2725                 2730             


Pro Asp  Leu His Ile Pro Glu  Phe Gln Leu Pro His  Ile Ser His 
    2735                 2740                 2745             


Thr Ile  Glu Val Pro Thr Phe  Gly Lys Leu Tyr Ser  Ile Leu Lys 
    2750                 2755                 2760             


Ile Gln  Ser Pro Leu Phe Thr  Leu Asp Ala Asn Ala  Asp Ile Gly 
    2765                 2770                 2775             


Asn Gly  Thr Thr Ser Ala Asn  Glu Ala Gly Ile Ala  Ala Ser Ile 
    2780                 2785                 2790             


Thr Ala  Lys Gly Glu Ser Lys  Leu Glu Val Leu Asn  Phe Asp Phe 
    2795                 2800                 2805             


Gln Ala  Asn Ala Gln Leu Ser  Asn Pro Lys Ile Asn  Pro Leu Ala 
    2810                 2815                 2820             


Leu Lys  Glu Ser Val Lys Phe  Ser Ser Lys Tyr Leu  Arg Thr Glu 
    2825                 2830                 2835             


His Gly  Ser Glu Met Leu Phe  Phe Gly Asn Ala Ile  Glu Gly Lys 
    2840                 2845                 2850             


Ser Asn  Thr Val Ala Ser Leu  His Thr Glu Lys Asn  Thr Leu Glu 
    2855                 2860                 2865             


Leu Ser  Asn Gly Val Ile Val  Lys Ile Asn Asn Gln  Leu Thr Leu 
    2870                 2875                 2880             


Asp Ser  Asn Thr Lys Tyr Phe  His Lys Leu Asn Ile  Pro Lys Leu 
    2885                 2890                 2895             


Asp Phe  Ser Ser Gln Ala Asp  Leu Arg Asn Glu Ile  Lys Thr Leu 
    2900                 2905                 2910             


Leu Lys  Ala Gly His Ile Ala  Trp Thr Ser Ser Gly  Lys Gly Ser 
    2915                 2920                 2925             


Trp Lys  Trp Ala Cys Pro Arg  Phe Ser Asp Glu Gly  Thr His Glu 
    2930                 2935                 2940             


Ser Gln  Ile Ser Phe Thr Ile  Glu Gly Pro Leu Thr  Ser Phe Gly 
    2945                 2950                 2955             


Leu Ser  Asn Lys Ile Asn Ser  Lys His Leu Arg Val  Asn Gln Asn 
    2960                 2965                 2970             


Leu Val  Tyr Glu Ser Gly Ser  Leu Asn Phe Ser Lys  Leu Glu Ile 
    2975                 2980                 2985             


Gln Ser  Gln Val Asp Ser Gln  His Val Gly His Ser  Val Leu Thr 
    2990                 2995                 3000             


Ala Lys  Gly Met Ala Leu Phe  Gly Glu Gly Lys Ala  Glu Phe Thr 
    3005                 3010                 3015             


Gly Arg  His Asp Ala His Leu  Asn Gly Lys Val Ile  Gly Thr Leu 
    3020                 3025                 3030             


Lys Asn  Ser Leu Phe Phe Ser  Ala Gln Pro Phe Glu  Ile Thr Ala 
    3035                 3040                 3045             


Ser Thr  Asn Asn Glu Gly Asn  Leu Lys Val Arg Phe  Pro Leu Arg 
    3050                 3055                 3060             


Leu Thr  Gly Lys Ile Asp Phe  Leu Asn Asn Tyr Ala  Leu Phe Leu 
    3065                 3070                 3075             


Ser Pro  Ser Ala Gln Gln Ala  Ser Trp Gln Val Ser  Ala Arg Phe 
    3080                 3085                 3090             


Asn Gln  Tyr Lys Tyr Asn Gln  Asn Phe Ser Ala Gly  Asn Asn Glu 
    3095                 3100                 3105             


Asn Ile  Met Glu Ala His Val  Gly Ile Asn Gly Glu  Ala Asn Leu 
    3110                 3115                 3120             


Asp Phe  Leu Asn Ile Pro Leu  Thr Ile Pro Glu Met  Arg Leu Pro 
    3125                 3130                 3135             


Tyr Thr  Ile Ile Thr Thr Pro  Pro Leu Lys Asp Phe  Ser Leu Trp 
    3140                 3145                 3150             


Glu Lys  Thr Gly Leu Lys Glu  Phe Leu Lys Thr Thr  Lys Gln Ser 
    3155                 3160                 3165             


Phe Asp  Leu Ser Val Lys Ala  Gln Tyr Lys Lys Asn  Lys His Arg 
    3170                 3175                 3180             


His Ser  Ile Thr Asn Pro Leu  Ala Val Leu Cys Glu  Phe Ile Ser 
    3185                 3190                 3195             


Gln Ser  Ile Lys Ser Phe Asp  Arg His Phe Glu Lys  Asn Arg Asn 
    3200                 3205                 3210             


Asn Ala  Leu Asp Phe Val Thr  Lys Ser Tyr Asn Glu  Thr Lys Ile 
    3215                 3220                 3225             


Lys Phe  Asp Lys Tyr Lys Ala  Glu Lys Ser His Asp  Glu Leu Pro 
    3230                 3235                 3240             


Arg Thr  Phe Gln Ile Pro Gly  Tyr Thr Val Pro Val  Val Asn Val 
    3245                 3250                 3255             


Glu Val  Ser Pro Phe Thr Ile  Glu Met Ser Ala Phe  Gly Tyr Val 
    3260                 3265                 3270             


Phe Pro  Lys Ala Val Ser Met  Pro Ser Phe Ser Ile  Leu Gly Ser 
    3275                 3280                 3285             


Asp Val  Arg Val Pro Ser Tyr  Thr Leu Ile Leu Pro  Ser Leu Glu 
    3290                 3295                 3300             


Leu Pro  Val Leu His Val Pro  Arg Asn Leu Lys Leu  Ser Leu Pro 
    3305                 3310                 3315             


Asp Phe  Lys Glu Leu Cys Thr  Ile Ser His Ile Phe  Ile Pro Ala 
    3320                 3325                 3330             


Met Gly  Asn Ile Thr Tyr Asp  Phe Ser Phe Lys Ser  Ser Val Ile 
    3335                 3340                 3345             


Thr Leu  Asn Thr Asn Ala Glu  Leu Phe Asn Gln Ser  Asp Ile Val 
    3350                 3355                 3360             


Ala His  Leu Leu Ser Ser Ser  Ser Ser Val Ile Asp  Ala Leu Gln 
    3365                 3370                 3375             


Tyr Lys  Leu Glu Gly Thr Thr  Arg Leu Thr Arg Lys  Arg Gly Leu 
    3380                 3385                 3390             


Lys Leu  Ala Thr Ala Leu Ser  Leu Ser Asn Lys Phe  Val Glu Gly 
    3395                 3400                 3405             


Ser His  Asn Ser Thr Val Ser  Leu Thr Thr Lys Asn  Met Glu Val 
    3410                 3415                 3420             


Ser Val  Ala Thr Thr Thr Lys  Ala Gln Ile Pro Ile  Leu Arg Met 
    3425                 3430                 3435             


Asn Phe  Lys Gln Glu Leu Asn  Gly Asn Thr Lys Ser  Lys Pro Thr 
    3440                 3445                 3450             


Val Ser  Ser Ser Met Glu Phe  Lys Tyr Asp Phe Asn  Ser Ser Met 
    3455                 3460                 3465             


Leu Tyr  Ser Thr Ala Lys Gly  Ala Val Asp His Lys  Leu Ser Leu 
    3470                 3475                 3480             


Glu Ser  Leu Thr Ser Tyr Phe  Ser Ile Glu Ser Ser  Thr Lys Gly 
    3485                 3490                 3495             


Asp Val  Lys Gly Ser Val Leu  Ser Arg Glu Tyr Ser  Gly Thr Ile 
    3500                 3505                 3510             


Ala Ser  Glu Ala Asn Thr Tyr  Leu Asn Ser Lys Ser  Thr Arg Ser 
    3515                 3520                 3525             


Ser Val  Lys Leu Gln Gly Thr  Ser Lys Ile Asp Asp  Ile Trp Asn 
    3530                 3535                 3540             


Leu Glu  Val Lys Glu Asn Phe  Ala Gly Glu Ala Thr  Leu Gln Arg 
    3545                 3550                 3555             


Ile Tyr  Ser Leu Trp Glu His  Ser Thr Lys Asn His  Leu Gln Leu 
    3560                 3565                 3570             


Glu Gly  Leu Phe Phe Thr Asn  Gly Glu His Thr Ser  Lys Ala Thr 
    3575                 3580                 3585             


Leu Glu  Leu Ser Pro Trp Gln  Met Ser Ala Leu Val  Gln Val His 
    3590                 3595                 3600             


Ala Ser  Gln Pro Ser Ser Phe  His Asp Phe Pro Asp  Leu Gly Gln 
    3605                 3610                 3615             


Glu Val  Ala Leu Asn Ala Asn  Thr Lys Asn Gln Lys  Ile Arg Trp 
    3620                 3625                 3630             


Lys Asn  Glu Val Arg Ile His  Ser Gly Ser Phe Gln  Ser Gln Val 
    3635                 3640                 3645             


Glu Leu  Ser Asn Asp Gln Glu  Lys Ala His Leu Asp  Ile Ala Gly 
    3650                 3655                 3660             


Ser Leu  Glu Gly His Leu Arg  Phe Leu Lys Asn Ile  Ile Leu Pro 
    3665                 3670                 3675             


Val Tyr  Asp Lys Ser Leu Trp  Asp Phe Leu Lys Leu  Asp Val Thr 
    3680                 3685                 3690             


Thr Ser  Ile Gly Arg Arg Gln  His Leu Arg Val Ser  Thr Ala Phe 
    3695                 3700                 3705             


Val Tyr  Thr Lys Asn Pro Asn  Gly Tyr Ser Phe Ser  Ile Pro Val 
    3710                 3715                 3720             


Lys Val  Leu Ala Asp Lys Phe  Ile Ile Pro Gly Leu  Lys Leu Asn 
    3725                 3730                 3735             


Asp Leu  Asn Ser Val Leu Val  Met Pro Thr Phe His  Val Pro Phe 
    3740                 3745                 3750             


Thr Asp  Leu Gln Val Pro Ser  Cys Lys Leu Asp Phe  Arg Glu Ile 
    3755                 3760                 3765             


Gln Ile  Tyr Lys Lys Leu Arg  Thr Ser Ser Phe Ala  Leu Asn Leu 
    3770                 3775                 3780             


Pro Thr  Leu Pro Glu Val Lys  Phe Pro Glu Val Asp  Val Leu Thr 
    3785                 3790                 3795             


Lys Tyr  Ser Gln Pro Glu Asp  Ser Leu Ile Pro Phe  Phe Glu Ile 
    3800                 3805                 3810             


Thr Val  Pro Glu Ser Gln Leu  Thr Val Ser Gln Phe  Thr Leu Pro 
    3815                 3820                 3825             


Lys Ser  Val Ser Asp Gly Ile  Ala Ala Leu Asp Leu  Asn Ala Val 
    3830                 3835                 3840             


Ala Asn  Lys Ile Ala Asp Phe  Glu Leu Pro Thr Ile  Ile Val Pro 
    3845                 3850                 3855             


Glu Gln  Thr Ile Glu Ile Pro  Ser Ile Lys Phe Ser  Val Pro Ala 
    3860                 3865                 3870             


Gly Ile  Val Ile Pro Ser Phe  Gln Ala Leu Thr Ala  Arg Phe Glu 
    3875                 3880                 3885             


Val Asp  Ser Pro Val Tyr Asn  Ala Thr Trp Ser Ala  Ser Leu Lys 
    3890                 3895                 3900             


Asn Lys  Ala Asp Tyr Val Glu  Thr Val Leu Asp Ser  Thr Cys Ser 
    3905                 3910                 3915             


Ser Thr  Val Gln Phe Leu Glu  Tyr Glu Leu Asn Val  Leu Gly Thr 
    3920                 3925                 3930             


His Lys  Ile Glu Asp Gly Thr  Leu Ala Ser Lys Thr  Lys Gly Thr 
    3935                 3940                 3945             


Phe Ala  His Arg Asp Phe Ser  Ala Glu Tyr Glu Glu  Asp Gly Lys 
    3950                 3955                 3960             


Tyr Glu  Gly Leu Gln Glu Trp  Glu Gly Lys Ala His  Leu Asn Ile 
    3965                 3970                 3975             


Lys Ser  Pro Ala Phe Thr Asp  Leu His Leu Arg Tyr  Gln Lys Asp 
    3980                 3985                 3990             


Lys Lys  Gly Ile Ser Thr Ser  Ala Ala Ser Pro Ala  Val Gly Thr 
    3995                 4000                 4005             


Val Gly  Met Asp Met Asp Glu  Asp Asp Asp Phe Ser  Lys Trp Asn 
    4010                 4015                 4020             


Phe Tyr  Tyr Ser Pro Gln Ser  Ser Pro Asp Lys Lys  Leu Thr Ile 
    4025                 4030                 4035             


Phe Lys  Thr Glu Leu Arg Val  Arg Glu Ser Asp Glu  Glu Thr Gln 
    4040                 4045                 4050             


Ile Lys  Val Asn Trp Glu Glu  Glu Ala Ala Ser Gly  Leu Leu Thr 
    4055                 4060                 4065             


Ser Leu  Lys Asp Asn Val Pro  Lys Ala Thr Gly Val  Leu Tyr Asp 
    4070                 4075                 4080             


Tyr Val  Asn Lys Tyr His Trp  Glu His Thr Gly Leu  Thr Leu Arg 
    4085                 4090                 4095             


Glu Val  Ser Ser Lys Leu Arg  Arg Asn Leu Gln Asn  Asn Ala Glu 
    4100                 4105                 4110             


Trp Val  Tyr Gln Gly Ala Ile  Arg Gln Ile Asp Asp  Ile Asp Val 
    4115                 4120                 4125             


Arg Phe  Gln Lys Ala Ala Ser  Gly Thr Thr Gly Thr  Tyr Gln Glu 
    4130                 4135                 4140             


Trp Lys  Asp Lys Ala Gln Asn  Leu Tyr Gln Glu Leu  Leu Thr Gln 
    4145                 4150                 4155             


Glu Gly  Gln Ala Ser Phe Gln  Gly Leu Lys Asp Asn  Val Phe Asp 
    4160                 4165                 4170             


Gly Leu  Val Arg Val Thr Gln  Glu Phe His Met Lys  Val Lys His 
    4175                 4180                 4185             


Leu Ile  Asp Ser Leu Ile Asp  Phe Leu Asn Phe Pro  Arg Phe Gln 
    4190                 4195                 4200             


Phe Pro  Gly Lys Pro Gly Ile  Tyr Thr Arg Glu Glu  Leu Cys Thr 
    4205                 4210                 4215             


Met Phe  Ile Arg Glu Val Gly  Thr Val Leu Ser Gln  Val Tyr Ser 
    4220                 4225                 4230             


Lys Val  His Asn Gly Ser Glu  Ile Leu Phe Ser Tyr  Phe Gln Asp 
    4235                 4240                 4245             


Leu Val  Ile Thr Leu Pro Phe  Glu Leu Arg Lys His  Lys Leu Ile 
    4250                 4255                 4260             


Asp Val  Ile Ser Met Tyr Arg  Glu Leu Leu Lys Asp  Leu Ser Lys 
    4265                 4270                 4275             


Glu Ala  Gln Glu Val Phe Lys  Ala Ile Gln Ser Leu  Lys Thr Thr 
    4280                 4285                 4290             


Glu Val  Leu Arg Asn Leu Gln  Asp Leu Leu Gln Phe  Ile Phe Gln 
    4295                 4300                 4305             


Leu Ile  Glu Asp Asn Ile Lys  Gln Leu Lys Glu Met  Lys Phe Thr 
    4310                 4315                 4320             


Tyr Leu  Ile Asn Tyr Ile Gln  Asp Glu Ile Asn Thr  Ile Phe Ser 
    4325                 4330                 4335             


Asp Tyr  Ile Pro Tyr Val Phe  Lys Leu Leu Lys Glu  Asn Leu Cys 
    4340                 4345                 4350             


Leu Asn  Leu His Lys Phe Asn  Glu Phe Ile Gln Asn  Glu Leu Gln 
    4355                 4360                 4365             


Glu Ala  Ser Gln Glu Leu Gln  Gln Ile His Gln Tyr  Ile Met Ala 
    4370                 4375                 4380             


Leu Arg  Glu Glu Tyr Phe Asp  Pro Ser Ile Val Gly  Trp Thr Val 
    4385                 4390                 4395             


Lys Tyr  Tyr Glu Leu Glu Glu  Lys Ile Val Ser Leu  Ile Lys Asn 
    4400                 4405                 4410             


Leu Leu  Val Ala Leu Lys Asp  Phe His Ser Glu Tyr  Ile Val Ser 
    4415                 4420                 4425             


Ala Ser  Asn Phe Thr Ser Gln  Leu Ser Ser Gln Val  Glu Gln Phe 
    4430                 4435                 4440             


Leu His  Arg Asn Ile Gln Glu  Tyr Leu Ser Ile Leu  Thr Asp Pro 
    4445                 4450                 4455             


Asp Gly  Lys Gly Lys Glu Lys  Ile Ala Glu Leu Ser  Ala Thr Ala 
    4460                 4465                 4470             


Gln Glu  Ile Ile Lys Ser Gln  Ala Ile Ala Thr Lys  Lys Ile Ile 
    4475                 4480                 4485             


Ser Asp  Tyr His Gln Gln Phe  Arg Tyr Lys Leu Gln  Asp Phe Ser 
    4490                 4495                 4500             


Asp Gln  Leu Ser Asp Tyr Tyr  Glu Lys Phe Ile Ala  Glu Ser Lys 
    4505                 4510                 4515             


Arg Leu  Ile Asp Leu Ser Ile  Gln Asn Tyr His Thr  Phe Leu Ile 
    4520                 4525                 4530             


Tyr Ile  Thr Glu Leu Leu Lys  Lys Leu Gln Ser Thr  Thr Val Met 
    4535                 4540                 4545             


Asn Pro  Tyr Met Lys Leu Ala  Pro Gly Glu Leu Thr  Ile Ile Leu 
    4550                 4555                 4560             


<210>  948
<211>  828
<212>  PRT
<213>  Homo Sapiens

<400>  948

Met Asp Pro Pro Arg Pro Ala Leu Leu Ala Leu Leu Ala Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Ala Gly Ala Arg Ala Glu Glu Glu Met Leu 
            20                  25                  30          


Glu Asn Val Ser Leu Val Cys Pro Lys Asp Ala Thr Arg Phe Lys His 
        35                  40                  45              


Leu Arg Lys Tyr Thr Tyr Asn Tyr Glu Ala Glu Ser Ser Ser Gly Val 
    50                  55                  60                  


Pro Gly Thr Ala Asp Ser Arg Ser Ala Thr Arg Ile Asn Cys Lys Val 
65                  70                  75                  80  


Glu Leu Glu Val Pro Gln Leu Cys Ser Phe Ile Leu Lys Thr Ser Gln 
                85                  90                  95      


Cys Thr Leu Lys Glu Val Tyr Gly Phe Asn Pro Glu Gly Lys Ala Leu 
            100                 105                 110         


Leu Lys Lys Thr Lys Asn Ser Glu Glu Phe Ala Ala Ala Met Ser Arg 
        115                 120                 125             


Tyr Glu Leu Lys Leu Ala Ile Pro Glu Gly Lys Gln Val Phe Leu Tyr 
    130                 135                 140                 


Pro Glu Lys Asp Glu Pro Thr Tyr Ile Leu Asn Ile Lys Arg Gly Ile 
145                 150                 155                 160 


Ile Ser Ala Leu Leu Val Pro Pro Glu Thr Glu Glu Ala Lys Gln Val 
                165                 170                 175     


Leu Phe Leu Asp Thr Val Tyr Gly Asn Cys Ser Thr His Phe Thr Val 
            180                 185                 190         


Lys Thr Arg Lys Gly Asn Val Ala Thr Glu Ile Ser Thr Glu Arg Asp 
        195                 200                 205             


Leu Gly Gln Cys Asp Arg Phe Lys Pro Ile Arg Thr Gly Ile Ser Pro 
    210                 215                 220                 


Leu Ala Leu Ile Lys Gly Met Thr Arg Pro Leu Ser Thr Leu Ile Ser 
225                 230                 235                 240 


Ser Ser Gln Ser Cys Gln Tyr Thr Leu Asp Ala Lys Arg Lys His Val 
                245                 250                 255     


Ala Glu Ala Ile Cys Lys Glu Gln His Leu Phe Leu Pro Phe Ser Tyr 
            260                 265                 270         


Lys Asn Lys Tyr Gly Met Val Ala Gln Val Thr Gln Thr Leu Lys Leu 
        275                 280                 285             


Glu Asp Thr Pro Lys Ile Asn Ser Arg Phe Phe Gly Glu Gly Thr Lys 
    290                 295                 300                 


Lys Met Gly Leu Ala Phe Glu Ser Thr Lys Ser Thr Ser Pro Pro Lys 
305                 310                 315                 320 


Gln Ala Glu Ala Val Leu Lys Thr Leu Gln Glu Leu Lys Lys Leu Thr 
                325                 330                 335     


Ile Ser Glu Gln Asn Ile Gln Arg Ala Asn Leu Phe Asn Lys Leu Val 
            340                 345                 350         


Thr Glu Leu Arg Gly Leu Ser Asp Glu Ala Val Thr Ser Leu Leu Pro 
        355                 360                 365             


Gln Leu Ile Glu Val Ser Ser Pro Ile Thr Leu Gln Ala Leu Val Gln 
    370                 375                 380                 


Cys Gly Gln Pro Gln Cys Ser Thr His Ile Leu Gln Trp Leu Lys Arg 
385                 390                 395                 400 


Val His Ala Asn Pro Leu Leu Ile Asp Val Val Thr Tyr Leu Val Ala 
                405                 410                 415     


Leu Ile Pro Glu Pro Ser Ala Gln Gln Leu Arg Glu Ile Phe Asn Met 
            420                 425                 430         


Ala Arg Asp Gln Arg Ser Arg Ala Thr Leu Tyr Ala Leu Ser His Ala 
        435                 440                 445             


Val Asn Asn Tyr His Lys Thr Asn Pro Thr Gly Thr Gln Glu Leu Leu 
    450                 455                 460                 


Asp Ile Ala Asn Tyr Leu Met Glu Gln Ile Gln Asp Asp Cys Thr Gly 
465                 470                 475                 480 


Asp Glu Asp Tyr Thr Tyr Leu Ile Leu Arg Val Ile Gly Asn Met Gly 
                485                 490                 495     


Gln Thr Met Glu Gln Leu Thr Pro Glu Leu Lys Ser Ser Ile Leu Lys 
            500                 505                 510         


Cys Val Gln Ser Thr Lys Pro Ser Leu Met Ile Gln Lys Ala Ala Ile 
        515                 520                 525             


Gln Ala Leu Arg Lys Met Glu Pro Lys Asp Lys Asp Gln Glu Val Leu 
    530                 535                 540                 


Leu Gln Thr Phe Leu Asp Asp Ala Ser Pro Gly Asp Lys Arg Leu Ala 
545                 550                 555                 560 


Ala Tyr Leu Met Leu Met Arg Ser Pro Ser Gln Ala Asp Ile Asn Lys 
                565                 570                 575     


Ile Val Gln Ile Leu Pro Trp Glu Gln Asn Glu Gln Val Lys Asn Phe 
            580                 585                 590         


Val Ala Ser His Ile Ala Asn Ile Leu Asn Ser Glu Glu Leu Asp Ile 
        595                 600                 605             


Gln Asp Leu Lys Lys Leu Val Lys Glu Ala Leu Lys Glu Ser Gln Leu 
    610                 615                 620                 


Pro Thr Val Met Asp Phe Arg Lys Phe Ser Arg Asn Tyr Gln Leu Tyr 
625                 630                 635                 640 


Lys Ser Val Ser Leu Pro Ser Leu Asp Pro Ala Ser Ala Lys Ile Glu 
                645                 650                 655     


Gly Asn Leu Ile Phe Asp Pro Asn Asn Tyr Leu Pro Lys Glu Ser Met 
            660                 665                 670         


Leu Lys Thr Thr Leu Thr Ala Phe Gly Phe Ala Ser Ala Asp Leu Ile 
        675                 680                 685             


Glu Ile Gly Leu Glu Gly Lys Gly Phe Glu Pro Thr Leu Glu Ala Leu 
    690                 695                 700                 


Phe Gly Lys Gln Gly Phe Phe Pro Asp Ser Val Asn Lys Ala Leu Tyr 
705                 710                 715                 720 


Trp Val Asn Gly Gln Val Pro Asp Gly Val Ser Lys Val Leu Val Asp 
                725                 730                 735     


His Phe Gly Tyr Thr Lys Asp Asp Lys His Glu Gln Asp Met Val Asn 
            740                 745                 750         


Gly Ile Met Leu Ser Val Glu Lys Leu Ile Lys Asp Leu Lys Ser Lys 
        755                 760                 765             


Glu Val Pro Glu Ala Arg Ala Tyr Leu Arg Ile Leu Gly Glu Glu Leu 
    770                 775                 780                 


Gly Phe Ala Ser Leu His Asp Leu Gln Leu Leu Gly Lys Leu Leu Leu 
785                 790                 795                 800 


Met Asp Arg Pro Asp Ser Leu Thr Ile Pro Ala Ala Gln Ala Arg Lys 
                805                 810                 815     


Asp Ala Cys Thr Phe Phe Arg Asp Gly Gly Leu Pro 
            820                 825             


<210>  949
<211>  54
<212>  PRT
<213>  Homo Sapiens

<400>  949

Met Arg Leu Phe Leu Ser Leu Pro Val Leu Val Val Val Leu Ser Ile 
1               5                   10                  15      


Val Leu Glu Gly Pro Ala Pro Ala Gln Gly Thr Pro Asp Val Ser Ser 
            20                  25                  30          


Ala Leu Asp Lys Leu Lys Glu Phe Gly Asn Thr Leu Glu Asp Lys Ala 
        35                  40                  45              


Arg Glu Leu Ile Ser Arg 
    50                  


<210>  950
<211>  83
<212>  PRT
<213>  Homo Sapiens

<400>  950

Met Arg Leu Phe Leu Ser Leu Pro Val Leu Val Val Val Leu Ser Ile 
1               5                   10                  15      


Val Leu Glu Gly Pro Ala Pro Ala Gln Gly Thr Pro Asp Val Ser Ser 
            20                  25                  30          


Ala Leu Asp Lys Leu Lys Glu Phe Gly Asn Thr Leu Glu Asp Lys Ala 
        35                  40                  45              


Arg Glu Leu Ile Ser Arg Ile Lys Gln Ser Glu Leu Ser Ala Lys Met 
    50                  55                  60                  


Arg Glu Asp Asp Ile Ser Pro Cys Cys Pro Gly Trp Ser Arg Thr Pro 
65                  70                  75                  80  


Asp Leu Lys 
            


<210>  951
<211>  77
<212>  PRT
<213>  Homo Sapiens

<400>  951

Met Arg Leu Phe Leu Ser Leu Pro Val Leu Val Val Val Leu Ser Ile 
1               5                   10                  15      


Val Leu Glu Gly Pro Ala Pro Ala Gln Gly Thr Pro Asp Val Ser Ser 
            20                  25                  30          


Ala Leu Asp Lys Leu Lys Glu Phe Gly Asn Thr Leu Glu Asp Lys Ala 
        35                  40                  45              


Arg Glu Leu Ile Ser Arg Ile Lys Gln Ser Glu Leu Ser Ala Lys Met 
    50                  55                  60                  


Arg Glu Trp Phe Ser Glu Thr Phe Gln Lys Val Lys Glu 
65                  70                  75          


<210>  952
<211>  83
<212>  PRT
<213>  Homo Sapiens

<400>  952

Met Arg Leu Phe Leu Ser Leu Pro Val Leu Val Val Val Leu Ser Ile 
1               5                   10                  15      


Val Leu Glu Gly Pro Ala Pro Ala Gln Gly Thr Pro Asp Val Ser Ser 
            20                  25                  30          


Ala Leu Asp Lys Leu Lys Glu Phe Gly Asn Thr Leu Glu Asp Lys Ala 
        35                  40                  45              


Arg Glu Leu Ile Ser Arg Ile Lys Gln Ser Glu Leu Ser Ala Lys Met 
    50                  55                  60                  


Arg Glu Trp Phe Ser Glu Thr Phe Gln Lys Val Lys Glu Lys Leu Lys 
65                  70                  75                  80  


Ile Asp Ser 
            


<210>  953
<211>  83
<212>  PRT
<213>  Homo Sapiens

<400>  953

Met Arg Leu Phe Leu Ser Leu Pro Val Leu Val Val Val Leu Ser Ile 
1               5                   10                  15      


Val Leu Glu Gly Pro Ala Pro Ala Gln Gly Thr Pro Asp Val Ser Ser 
            20                  25                  30          


Ala Leu Asp Lys Leu Lys Glu Phe Gly Asn Thr Leu Glu Asp Lys Ala 
        35                  40                  45              


Arg Glu Leu Ile Ser Arg Ile Lys Gln Ser Glu Leu Ser Ala Lys Met 
    50                  55                  60                  


Arg Glu Trp Phe Ser Glu Thr Phe Gln Lys Val Lys Glu Lys Leu Lys 
65                  70                  75                  80  


Ile Asp Ser 
            


<210>  954
<211>  92
<212>  PRT
<213>  Homo Sapiens

<400>  954

Met Arg Leu Phe Leu Ser Leu Pro Val Leu Val Val Val Leu Ser Ile 
1               5                   10                  15      


Val Leu Glu Gly Pro Ala Pro Ala Gln Gly Thr Pro Asp Val Ser Ser 
            20                  25                  30          


Ala Leu Asp Lys Leu Lys Glu Phe Gly Asn Thr Leu Glu Asp Lys Ala 
        35                  40                  45              


Arg Glu Leu Ile Ser Arg Ile Lys Gln Ser Glu Leu Ser Ala Lys Met 
    50                  55                  60                  


Arg Leu Glu Pro Phe Pro Gly His Gly Arg Ala Gly Gly Val Val Phe 
65                  70                  75                  80  


Arg Asp Ile Ser Glu Ser Glu Gly Glu Thr Gln Asp 
                85                  90          


<210>  955
<211>  129
<212>  PRT
<213>  Homo Sapiens

<400>  955

Met Arg Leu Phe Leu Ser Leu Pro Val Leu Val Val Val Leu Ser Ile 
1               5                   10                  15      


Val Leu Glu Gly Pro Ala Pro Ala Gln Gly Thr Pro Asp Val Ser Ser 
            20                  25                  30          


Ala Leu Asp Lys Leu Lys Glu Phe Gly Asn Thr Leu Glu Asp Lys Ala 
        35                  40                  45              


Arg Glu Leu Ile Ser Arg Ile Lys Gln Ser Glu Leu Ser Ala Lys Met 
    50                  55                  60                  


Arg Leu Glu Pro Phe Pro Gly His Gly Arg Ala Gly Val Cys Phe Trp 
65                  70                  75                  80  


Val Glu Pro Trp Gln Met Val Gln Asp Glu Gln Ile Glu Lys Lys Thr 
                85                  90                  95      


Ser Pro Gly Glu Ala Asp Asn Ile Pro Leu Val Thr Gln Leu Asp Leu 
            100                 105                 110         


Lys Gly Val Val Phe Arg Asp Ile Ser Glu Ser Glu Gly Glu Thr Gln 
        115                 120                 125             


Asp 
    


<210>  956
<211>  29
<212>  PRT
<213>  Homo Sapiens

<400>  956

Met Arg Leu Phe Leu Ser Leu Pro Val Leu Val Val Val Leu Ser Ile 
1               5                   10                  15      


Val Leu Glu Gly Ser Gly Phe Gln Arg His Phe Arg Lys 
            20                  25                  


<210>  957
<211>  39
<212>  PRT
<213>  Homo Sapiens

<400>  957

Met Arg Leu Phe Leu Ser Leu Pro Val Leu Val Val Val Leu Ser Ile 
1               5                   10                  15      


Val Leu Glu Gly Ser Pro Arg Leu Ser Pro Ala Gly Ala Lys Ser Ala 
            20                  25                  30          


Gln Glu Ser Thr Ser Asn Arg 
        35                  


<210>  958
<211>  87
<212>  PRT
<213>  Homo Sapiens

<400>  958

Met Gly Thr Arg Leu Leu Pro Ala Leu Phe Leu Val Leu Leu Val Leu 
1               5                   10                  15      


Gly Phe Glu Val Gln Gly Thr Gln Gln Pro Gln Gln Asp Glu Met Pro 
            20                  25                  30          


Ser Pro Thr Phe Leu Thr Gln Val Lys Glu Ser Leu Ser Ser Tyr Trp 
        35                  40                  45              


Glu Ser Ala Lys Thr Ala Ala Gln Asn Leu Asp Leu Tyr Ser Lys Ser 
    50                  55                  60                  


Thr Ala Ala Met Ser Thr Tyr Thr Gly Ile Phe Thr Asp Gln Val Leu 
65                  70                  75                  80  


Ser Val Leu Lys Gly Glu Glu 
                85          


<210>  959
<211>  72
<212>  PRT
<213>  Homo Sapiens

<400>  959

Met Gly Thr Arg Leu Leu Pro Ala Leu Phe Leu Val Leu Leu Val Leu 
1               5                   10                  15      


Gly Phe Glu Val Gln Gly Thr Gln Gln Pro Gln Gln Asp Glu Met Pro 
            20                  25                  30          


Ser Pro Thr Phe Leu Thr Gln Val Lys Glu Ser Leu Ser Ser Tyr Trp 
        35                  40                  45              


Glu Ser Ala Lys Thr Ala Ala Gln Asn Leu Tyr Glu Lys Thr Tyr Leu 
    50                  55                  60                  


Pro Ala Val Asp Glu Lys Leu Arg 
65                  70          


<210>  960
<211>  101
<212>  PRT
<213>  Homo Sapiens

<400>  960

Met Gly Thr Arg Leu Leu Pro Ala Leu Phe Leu Val Leu Leu Val Leu 
1               5                   10                  15      


Gly Phe Glu Val Gln Gly Thr Gln Gln Pro Gln Gln Asp Glu Met Pro 
            20                  25                  30          


Ser Pro Thr Phe Leu Thr Gln Val Lys Glu Ser Leu Ser Ser Tyr Trp 
        35                  40                  45              


Glu Ser Ala Lys Thr Ala Ala Gln Asn Leu Tyr Glu Lys Thr Tyr Leu 
    50                  55                  60                  


Pro Ala Val Asp Glu Lys Leu Arg Asp Leu Tyr Ser Lys Ser Thr Ala 
65                  70                  75                  80  


Ala Met Ser Thr Tyr Thr Gly Ile Phe Thr Asp Gln Val Leu Ser Val 
                85                  90                  95      


Leu Lys Gly Glu Glu 
            100     


<210>  961
<211>  101
<212>  PRT
<213>  Homo Sapiens

<400>  961

Met Gly Thr Arg Leu Leu Pro Ala Leu Phe Leu Val Leu Leu Val Leu 
1               5                   10                  15      


Gly Phe Glu Val Gln Gly Thr Gln Gln Pro Gln Gln Asp Glu Met Pro 
            20                  25                  30          


Ser Pro Thr Phe Leu Thr Gln Val Lys Glu Ser Leu Ser Ser Tyr Trp 
        35                  40                  45              


Glu Ser Ala Lys Thr Ala Ala Gln Asn Leu Tyr Glu Lys Thr Tyr Leu 
    50                  55                  60                  


Pro Ala Val Asp Glu Lys Leu Arg Asp Leu Tyr Ser Lys Ser Thr Ala 
65                  70                  75                  80  


Ala Met Ser Thr Tyr Thr Gly Ile Phe Thr Asp Gln Val Leu Ser Val 
                85                  90                  95      


Leu Lys Gly Glu Glu 
            100     


<210>  962
<211>  47
<212>  PRT
<213>  Homo Sapiens

<400>  962

Met Gly Thr Arg Leu Leu Pro Ala Leu Phe Leu Val Leu Leu Val Leu 
1               5                   10                  15      


Gly Phe Gly Glu Gly Ile Ser Leu Gln Leu Leu Gly Val Ser Lys Asp 
            20                  25                  30          


Ser Arg Pro Glu Pro Val Arg Glu Asp Ile Pro Ala Arg Cys Arg 
        35                  40                  45          


<210>  963
<211>  117
<212>  PRT
<213>  Homo Sapiens

<400>  963

Met Gly Thr Trp Gly Ala Pro His Arg Thr Leu Pro Cys Arg Asn Arg 
1               5                   10                  15      


Gly Ala Met Gln Pro Arg Val Leu Leu Val Val Ala Leu Leu Ala Leu 
            20                  25                  30          


Leu Ala Ser Ala Arg Ala Ser Glu Ala Glu Asp Ala Ser Leu Leu Ser 
        35                  40                  45              


Phe Met Gln Gly Tyr Met Lys His Ala Thr Lys Thr Ala Lys Asp Ala 
    50                  55                  60                  


Leu Ser Ser Val Gln Glu Ser Gln Val Ala Gln Gln Ala Arg Gly Trp 
65                  70                  75                  80  


Val Thr Asp Gly Phe Ser Ser Leu Lys Asp Tyr Trp Ser Thr Val Lys 
                85                  90                  95      


Asp Lys Phe Ser Glu Phe Trp Asp Leu Asp Pro Glu Val Arg Pro Thr 
            100                 105                 110         


Ser Ala Val Ala Ala 
        115         


<210>  964
<211>  117
<212>  PRT
<213>  Homo Sapiens

<400>  964

Met Gly Thr Trp Gly Ala Pro His Arg Thr Leu Pro Cys Arg Asn Arg 
1               5                   10                  15      


Gly Ala Met Gln Pro Arg Val Leu Leu Val Val Ala Leu Leu Ala Leu 
            20                  25                  30          


Leu Ala Ser Ala Arg Ala Ser Glu Ala Glu Asp Ala Ser Leu Leu Ser 
        35                  40                  45              


Phe Met Gln Gly Tyr Met Lys His Ala Thr Lys Thr Ala Lys Asp Ala 
    50                  55                  60                  


Leu Ser Ser Val Gln Glu Ser Gln Val Ala Gln Gln Ala Arg Gly Trp 
65                  70                  75                  80  


Val Thr Asp Gly Phe Ser Ser Leu Lys Asp Tyr Trp Ser Thr Val Lys 
                85                  90                  95      


Asp Lys Phe Ser Glu Phe Trp Asp Leu Asp Pro Glu Val Arg Pro Thr 
            100                 105                 110         


Ser Ala Val Ala Ala 
        115         


<210>  965
<211>  55
<212>  PRT
<213>  Homo Sapiens

<400>  965

Met Gln Pro Arg Val Leu Leu Val Val Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ser Ala Arg Ala Ser Glu Ala Glu Asp Ala Ser Leu Leu Ser Phe Met 
            20                  25                  30          


Gln Gly Tyr Met Lys His Ala Thr Lys Thr Ala Lys Asp Ala Leu Ser 
        35                  40                  45              


Ser Val Gln Glu Ser Gln Val 
    50                  55  


<210>  966
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  966

Met Gln Pro Arg Val Leu Leu Val Val Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ser Ala Arg Ala Ser Glu Ala Glu Asp Ala Ser Leu Leu Ser Phe Met 
            20                  25                  30          


Gln Gly Tyr Met Lys His Ala Thr Lys Thr Ala Lys Asp Ala Leu Ser 
        35                  40                  45              


Ser Val Gln Glu Ser Gln Val Ala Gln Gln Ala Arg Gly Trp Val Thr 
    50                  55                  60                  


Asp Gly Phe Ser Ser Leu Lys Asp Tyr Trp Ser Thr Val Lys Asp Lys 
65                  70                  75                  80  


Phe Ser Glu Phe Trp Asp Leu Asp Pro Glu Val Arg Pro Thr Ser Ala 
                85                  90                  95      


Val Ala Ala 
            


<210>  967
<211>  73
<212>  PRT
<213>  Homo Sapiens

<400>  967

Met Ser Leu Leu Arg Asn Arg Leu Gln Ala Leu Pro Ala Leu Cys Leu 
1               5                   10                  15      


Cys Val Leu Val Leu Ala Cys Ile Gly Ala Cys Gln Pro Glu Ala Gln 
            20                  25                  30          


Glu Gly Thr Leu Ser Pro Pro Pro Lys Leu Lys Met Ser Arg Trp Ser 
        35                  40                  45              


Leu Val Arg Gly Arg Met Lys Glu Leu Leu Glu Thr Val Val Asn Arg 
    50                  55                  60                  


Thr Arg Asp Gly Trp Gln Trp Phe Trp 
65                  70              


<210>  968
<211>  127
<212>  PRT
<213>  Homo Sapiens

<400>  968

Met Ser Leu Leu Arg Asn Arg Leu Gln Ala Leu Pro Ala Leu Cys Leu 
1               5                   10                  15      


Cys Val Leu Val Leu Ala Cys Ile Gly Ala Cys Gln Pro Glu Ala Gln 
            20                  25                  30          


Glu Gly Thr Leu Ser Pro Pro Pro Lys Leu Lys Met Ser Arg Trp Ser 
        35                  40                  45              


Leu Val Arg Gly Arg Met Lys Glu Leu Leu Glu Thr Val Val Asn Arg 
    50                  55                  60                  


Thr Arg Asp Gly Trp Gln Trp Phe Trp Ser Pro Ser Thr Phe Arg Gly 
65                  70                  75                  80  


Phe Met Gln Thr Tyr Tyr Asp Asp His Leu Arg Asp Leu Gly Pro Leu 
                85                  90                  95      


Thr Lys Ala Trp Phe Leu Glu Ser Lys Asp Ser Leu Leu Lys Lys Thr 
            100                 105                 110         


His Ser Leu Cys Pro Arg Leu Val Cys Gly Asp Lys Asp Gln Gly 
        115                 120                 125         


<210>  969
<211>  178
<212>  PRT
<213>  Homo Sapiens

<400>  969

Met Ser Leu Leu Arg Asn Arg Leu Gln Ala Leu Pro Ala Leu Cys Leu 
1               5                   10                  15      


Cys Val Leu Val Leu Ala Cys Ile Gly Ala Cys Gln Pro Glu Ala Gln 
            20                  25                  30          


Glu Gly Thr Leu Ser Pro Pro Pro Lys Leu Lys Met Ser Arg Trp Ser 
        35                  40                  45              


Leu Val Arg Gly Arg Met Lys Glu Leu Leu Glu Thr Val Val Asn Arg 
    50                  55                  60                  


Thr Arg Asp Gly Trp Gln Trp Phe Trp Ser Leu Asp Thr Met Gly Thr 
65                  70                  75                  80  


Arg Leu Leu Pro Ala Leu Phe Leu Val Leu Leu Val Leu Gly Phe Glu 
                85                  90                  95      


Val Gln Gly Thr Gln Gln Pro Gln Gln Asp Glu Met Pro Ser Pro Thr 
            100                 105                 110         


Phe Leu Thr Gln Val Lys Glu Ser Leu Ser Ser Tyr Trp Glu Ser Ala 
        115                 120                 125             


Lys Thr Ala Ala Gln Asn Leu Tyr Glu Lys Thr Tyr Leu Pro Ala Val 
    130                 135                 140                 


Asp Glu Lys Leu Arg Asp Leu Tyr Ser Lys Ser Thr Ala Ala Met Ser 
145                 150                 155                 160 


Thr Tyr Thr Gly Ile Phe Thr Asp Gln Val Leu Ser Val Leu Lys Gly 
                165                 170                 175     


Glu Glu 
        


<210>  970
<211>  127
<212>  PRT
<213>  Homo Sapiens

<400>  970

Met Ser Leu Leu Arg Asn Arg Leu Gln Ala Leu Pro Ala Leu Cys Leu 
1               5                   10                  15      


Cys Val Leu Val Leu Ala Cys Ile Gly Ala Cys Gln Pro Glu Ala Gln 
            20                  25                  30          


Glu Gly Thr Leu Ser Pro Pro Pro Lys Leu Lys Met Ser Arg Trp Ser 
        35                  40                  45              


Leu Val Arg Gly Arg Met Lys Glu Leu Leu Glu Thr Val Val Asn Arg 
    50                  55                  60                  


Thr Arg Asp Gly Trp Gln Trp Phe Trp Ser Pro Ser Thr Phe Arg Gly 
65                  70                  75                  80  


Phe Met Gln Thr Tyr Tyr Asp Asp His Leu Arg Asp Leu Gly Pro Leu 
                85                  90                  95      


Thr Lys Ala Trp Phe Leu Glu Ser Lys Asp Ser Leu Leu Lys Lys Thr 
            100                 105                 110         


His Ser Leu Cys Pro Arg Leu Val Cys Gly Asp Lys Asp Gln Gly 
        115                 120                 125         


<210>  971
<211>  215
<212>  PRT
<213>  Homo Sapiens

<400>  971

Met Phe Lys Gln Leu Ser Cys Ile Ser Leu Pro Ser Ser Cys Asp Tyr 
1               5                   10                  15      


Ser Ser Arg Ser Leu Leu Gln Pro Pro Ser Pro Lys Met Val Met Leu 
            20                  25                  30          


Leu Leu Leu Leu Ser Ala Leu Ala Gly Leu Phe Gly Ala Ala Glu Gly 
        35                  40                  45              


Gln Ala Phe His Leu Gly Lys Cys Pro Asn Pro Pro Val Gln Glu Asn 
    50                  55                  60                  


Phe Asp Val Asn Lys Tyr Leu Gly Arg Trp Tyr Glu Ile Glu Lys Ile 
65                  70                  75                  80  


Pro Thr Thr Phe Glu Asn Gly Arg Cys Ile Gln Ala Asn Tyr Ser Leu 
                85                  90                  95      


Met Glu Asn Gly Lys Ile Lys Val Leu Asn Gln Glu Leu Arg Ala Asp 
            100                 105                 110         


Gly Thr Val Asn Gln Ile Glu Gly Glu Ala Thr Pro Val Asn Leu Thr 
        115                 120                 125             


Glu Pro Ala Lys Leu Glu Val Lys Phe Ser Trp Phe Met Pro Ser Ala 
    130                 135                 140                 


Pro Tyr Trp Ile Leu Ala Thr Asp Tyr Glu Asn Tyr Ala Leu Val Tyr 
145                 150                 155                 160 


Ser Cys Thr Cys Ile Ile Gln Leu Phe His Val Asp Phe Ala Trp Ile 
                165                 170                 175     


Leu Ala Arg Asn Pro Asn Leu Pro Pro Glu Thr Val Asp Ser Leu Lys 
            180                 185                 190         


Asn Ile Leu Thr Ser Asn Asn Ile Asp Val Lys Lys Met Thr Val Thr 
        195                 200                 205             


Asp Gln Val Asn Cys Pro Lys 
    210                 215 


<210>  972
<211>  108
<212>  PRT
<213>  Homo Sapiens

<400>  972

Met Val Met Leu Leu Leu Leu Leu Ser Ala Leu Ala Gly Leu Phe Gly 
1               5                   10                  15      


Ala Ala Glu Gly Gln Ala Phe His Leu Gly Lys Cys Pro Asn Pro Pro 
            20                  25                  30          


Val Gln Glu Asn Phe Asp Val Asn Lys Thr Glu Ser His Phe Val Thr 
        35                  40                  45              


Gln Gly Gly Val Gln His His His Leu Gly Ser Leu Gln Pro Pro Pro 
    50                  55                  60                  


Pro Gly Phe Lys Gln Phe Ser Cys Leu Ser Leu Pro Ser Ser Trp Asp 
65                  70                  75                  80  


Tyr Ser Ile Ser Glu Asp Gly Thr Lys Leu Arg Arg Ser Gln Gln Pro 
                85                  90                  95      


Leu Arg Met Asp Ala Ala Ser Arg Pro Thr Thr His 
            100                 105             


<210>  973
<211>  149
<212>  PRT
<213>  Homo Sapiens

<400>  973

Met Val Met Leu Leu Leu Leu Leu Ser Ala Leu Ala Gly Leu Phe Gly 
1               5                   10                  15      


Ala Ala Glu Gly Gln Ala Phe His Leu Gly Lys Cys Pro Asn Pro Pro 
            20                  25                  30          


Val Gln Glu Asn Phe Asp Val Asn Lys Tyr Leu Gly Arg Trp Tyr Glu 
        35                  40                  45              


Ile Glu Lys Ile Pro Thr Thr Phe Glu Asn Gly Arg Cys Ile Gln Ala 
    50                  55                  60                  


Asn Tyr Ser Leu Met Glu Asn Gly Lys Ile Lys Val Leu Asn Gln Glu 
65                  70                  75                  80  


Leu Arg Ala Asp Gly Thr Val Asn Gln Ile Glu Gly Glu Ala Thr Pro 
                85                  90                  95      


Val Asn Leu Thr Glu Pro Ala Lys Leu Glu Val Lys Phe Ser Trp Phe 
            100                 105                 110         


Met Pro Ser Ala Pro Tyr Trp Ile Leu Ala Thr Asp Tyr Glu Asn Tyr 
        115                 120                 125             


Ala Leu Val Tyr Ser Cys Thr Cys Ile Ile Gln Leu Phe His Val Asp 
    130                 135                 140                 


Phe Ala Trp Ile Leu 
145                 


<210>  974
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  974

Met Val Met Leu Leu Leu Leu Leu Ser Ala Leu Ala Gly Leu Phe Gly 
1               5                   10                  15      


Ala Ala Glu Gly Gln Ala Phe His Leu Gly Lys Cys Pro Asn Pro Pro 
            20                  25                  30          


Val Gln Glu Asn Phe Asp Val Asn Lys Tyr Leu Gly Arg Trp Tyr Glu 
        35                  40                  45              


Ile Glu Lys Ile Pro Thr Thr Phe Glu Asn Gly Arg Cys Ile Gln Ala 
    50                  55                  60                  


Asn Tyr Ser Leu Met Glu Asn Gly Lys Ile Lys Val Leu Asn Gln Glu 
65                  70                  75                  80  


Leu Arg Ala Asp Gly Thr Val Asn Gln Ile Glu Gly Glu Ala Thr Pro 
                85                  90                  95      


Val Asn Leu Thr Glu Pro Ala Lys Leu Glu Val Lys Phe Ser Trp Phe 
            100                 105                 110         


Met Pro Ser Ala Pro Tyr Trp Ile Leu Ala Thr Asp Tyr Glu Asn Tyr 
        115                 120                 125             


Ala Leu Val Tyr Ser Cys Thr Cys Ile Ile Gln Leu Phe His Val Asp 
    130                 135                 140                 


Phe Ala Trp Ile Leu Ala Arg Asn Pro Asn Leu Pro Pro Glu Thr Val 
145                 150                 155                 160 


Asp Ser Leu Lys Asn Ile Leu Thr Ser Asn Asn Ile Asp Val Lys Lys 
                165                 170                 175     


Met Thr Val Thr Asp Gln Val Asn Cys Pro Lys Leu Ser 
            180                 185                 


<210>  975
<211>  216
<212>  PRT
<213>  Homo Sapiens

<400>  975

Met Lys Val Leu Trp Ala Ala Leu Leu Val Thr Phe Leu Ala Gly Cys 
1               5                   10                  15      


Gln Ala Lys Val Glu Gln Ala Val Glu Thr Glu Pro Glu Pro Glu Leu 
            20                  25                  30          


Arg Gln Gln Thr Glu Trp Gln Ser Gly Gln Arg Trp Glu Leu Ala Leu 
        35                  40                  45              


Gly Arg Phe Trp Asp Tyr Leu Arg Trp Val Gln Thr Leu Ser Glu Gln 
    50                  55                  60                  


Val Gln Glu Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala 
65                  70                  75                  80  


Leu Met Asp Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu 
                85                  90                  95      


Glu Glu Gln Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser 
            100                 105                 110         


Lys Glu Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp 
        115                 120                 125             


Val Cys Gly Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu 
    130                 135                 140                 


Gly Gln Ser Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Arg 
145                 150                 155                 160 


Lys Leu Arg Lys Arg Leu Leu Arg Asp Ala Asp Asp Leu Gln Lys Arg 
                165                 170                 175     


Leu Ala Val Tyr Gln Ala Gly Ala Arg Glu Gly Ala Glu Arg Gly Leu 
            180                 185                 190         


Ser Ala Ile Arg Glu Arg Leu Gly Pro Leu Val Glu Gln Gly Arg Val 
        195                 200                 205             


Arg Ala Ala Thr Val Gly Ser Leu 
    210                 215     


<210>  976
<211>  219
<212>  PRT
<213>  Homo Sapiens

<400>  976

Met Lys Val Leu Trp Ala Ala Leu Leu Val Thr Phe Leu Ala Gly Cys 
1               5                   10                  15      


Gln Ala Lys Val Glu Gln Ala Val Glu Thr Glu Pro Glu Pro Glu Leu 
            20                  25                  30          


Arg Gln Gln Thr Glu Trp Gln Ser Gly Gln Arg Trp Glu Leu Ala Leu 
        35                  40                  45              


Gly Arg Phe Trp Asp Tyr Leu Arg Trp Val Gln Thr Leu Ser Glu Gln 
    50                  55                  60                  


Val Gln Glu Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala 
65                  70                  75                  80  


Leu Met Asp Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu 
                85                  90                  95      


Glu Glu Gln Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser 
            100                 105                 110         


Lys Glu Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp 
        115                 120                 125             


Val Cys Gly Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu 
    130                 135                 140                 


Gly Gln Ser Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Arg 
145                 150                 155                 160 


Lys Leu Arg Lys Arg Leu Leu Arg Asp Ala Asp Asp Leu Gln Lys Arg 
                165                 170                 175     


Leu Ala Val Tyr Gln Ala Gly Ala Arg Glu Gly Ala Glu Arg Gly Leu 
            180                 185                 190         


Ser Ala Ile Arg Glu Arg Leu Gly Pro Leu Val Glu Gln Gly Arg Val 
        195                 200                 205             


Arg Ala Ala Thr Val Gly Ser Leu Ala Gly Gln 
    210                 215                 


<210>  977
<211>  317
<212>  PRT
<213>  Homo Sapiens

<400>  977

Met Lys Val Leu Trp Ala Ala Leu Leu Val Thr Phe Leu Ala Gly Cys 
1               5                   10                  15      


Gln Ala Lys Val Glu Gln Ala Val Glu Thr Glu Pro Glu Pro Glu Leu 
            20                  25                  30          


Arg Gln Gln Thr Glu Trp Gln Ser Gly Gln Arg Trp Glu Leu Ala Leu 
        35                  40                  45              


Gly Arg Phe Trp Asp Tyr Leu Arg Trp Val Gln Thr Leu Ser Glu Gln 
    50                  55                  60                  


Val Gln Glu Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala 
65                  70                  75                  80  


Leu Met Asp Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu 
                85                  90                  95      


Glu Glu Gln Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser 
            100                 105                 110         


Lys Glu Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp 
        115                 120                 125             


Val Cys Gly Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu 
    130                 135                 140                 


Gly Gln Ser Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Arg 
145                 150                 155                 160 


Lys Leu Arg Lys Arg Leu Leu Arg Asp Ala Asp Asp Leu Gln Lys Arg 
                165                 170                 175     


Leu Ala Val Tyr Gln Ala Gly Ala Arg Glu Gly Ala Glu Arg Gly Leu 
            180                 185                 190         


Ser Ala Ile Arg Glu Arg Leu Gly Pro Leu Val Glu Gln Gly Arg Val 
        195                 200                 205             


Arg Ala Ala Thr Val Gly Ser Leu Ala Gly Gln Pro Leu Gln Glu Arg 
    210                 215                 220                 


Ala Gln Ala Trp Gly Glu Arg Leu Arg Ala Arg Met Glu Glu Met Gly 
225                 230                 235                 240 


Ser Arg Thr Arg Asp Arg Leu Asp Glu Val Lys Glu Gln Val Ala Glu 
                245                 250                 255     


Val Arg Ala Lys Leu Glu Glu Gln Ala Gln Gln Ile Arg Leu Gln Ala 
            260                 265                 270         


Glu Ala Phe Gln Ala Arg Leu Lys Ser Trp Phe Glu Pro Leu Val Glu 
        275                 280                 285             


Asp Met Gln Arg Gln Trp Ala Gly Leu Val Glu Lys Val Gln Ala Ala 
    290                 295                 300                 


Val Gly Thr Ser Ala Ala Pro Val Pro Ser Asp Asn His 
305                 310                 315         


<210>  978
<211>  269
<212>  PRT
<213>  Homo Sapiens

<400>  978

Met Ser Ser Gly Ala Ser Arg Lys Ser Trp Asp Pro Gly Asn Pro Trp 
1               5                   10                  15      


Pro Pro Asp Trp Pro Ile Thr Gly Arg Lys Met Lys Val Leu Trp Ala 
            20                  25                  30          


Ala Leu Leu Val Thr Phe Leu Ala Gly Cys Gln Ala Lys Val Glu Gln 
        35                  40                  45              


Ala Val Glu Thr Glu Pro Glu Pro Glu Leu Arg Gln Gln Thr Glu Trp 
    50                  55                  60                  


Gln Ser Gly Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe Trp Asp Tyr 
65                  70                  75                  80  


Leu Arg Trp Val Gln Thr Leu Ser Glu Gln Val Gln Glu Glu Leu Leu 
                85                  90                  95      


Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp Glu Thr Met 
            100                 105                 110         


Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln Leu Thr Pro 
        115                 120                 125             


Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu Gln Ala Ala 
    130                 135                 140                 


Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Cys Gly Arg Leu Val 
145                 150                 155                 160 


Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser Thr Glu Glu 
                165                 170                 175     


Leu Arg Val Arg Leu Ala Ser His Leu Arg Lys Leu Arg Lys Arg Leu 
            180                 185                 190         


Leu Arg Asp Ala Asp Asp Leu Gln Lys Arg Leu Ala Val Tyr Gln Ala 
        195                 200                 205             


Gly Ala Arg Glu Gly Ala Glu Arg Gly Leu Ser Ala Ile Arg Glu Arg 
    210                 215                 220                 


Leu Gly Pro Leu Val Glu Gln Gly Arg Val Arg Ala Ala Thr Val Gly 
225                 230                 235                 240 


Ser Leu Ala Gly Gln Pro Leu Gln Glu Arg Ala Gln Ala Trp Gly Glu 
                245                 250                 255     


Arg Leu Arg Ala Arg Met Glu Glu Met Gly Ser Arg Thr 
            260                 265                 


<210>  979
<211>  326
<212>  PRT
<213>  Homo Sapiens

<400>  979

Met Thr Gly Leu Cys Gly Tyr Ser Ala Pro Asp Met Arg Gly Leu Arg 
1               5                   10                  15      


Leu Ile Met Ile Pro Val Glu Leu Leu Leu Cys Tyr Leu Leu Leu His 
            20                  25                  30          


Pro Val Asp Ala Thr Ser Tyr Gly Lys Gln Thr Asn Val Leu Met His 
        35                  40                  45              


Phe Pro Leu Ser Leu Glu Ser Gln Thr Pro Ser Ser Asp Pro Leu Ser 
    50                  55                  60                  


Cys Gln Phe Leu His Pro Lys Ser Leu Pro Gly Phe Ser His Met Ala 
65                  70                  75                  80  


Pro Leu Pro Lys Phe Leu Val Ser Leu Ala Leu Arg Asn Ala Leu Glu 
                85                  90                  95      


Glu Ala Gly Cys Gln Ala Asp Val Trp Ala Leu Gln Leu Gln Leu Tyr 
            100                 105                 110         


Arg Gln Gly Gly Val Asn Ala Thr Gln Val Leu Ile Gln His Leu Arg 
        115                 120                 125             


Gly Leu Gln Lys Gly Arg Ser Thr Glu Arg Asn Val Ser Val Glu Ala 
    130                 135                 140                 


Leu Ala Ser Ala Leu Gln Leu Leu Ala Arg Glu Gln Gln Ser Thr Gly 
145                 150                 155                 160 


Arg Val Gly Arg Ser Leu Pro Thr Glu Asp Cys Glu Asn Glu Lys Glu 
                165                 170                 175     


Gln Ala Val His Asn Val Val Gln Leu Leu Pro Gly Val Gly Thr Phe 
            180                 185                 190         


Tyr Asn Leu Gly Thr Ala Leu Tyr Tyr Ala Thr Gln Asn Cys Leu Gly 
        195                 200                 205             


Lys Ala Arg Glu Arg Gly Arg Asp Gly Ala Ile Asp Leu Gly Tyr Asp 
    210                 215                 220                 


Leu Leu Met Thr Met Ala Gly Met Ser Gly Gly Pro Met Gly Leu Ala 
225                 230                 235                 240 


Ile Ser Ala Ala Leu Lys Pro Ala Leu Arg Ser Gly Val Gln Gln Leu 
                245                 250                 255     


Ile Gln Tyr Tyr Gln Asp Gln Lys Asp Ala Asn Ile Ser Gln Pro Glu 
            260                 265                 270         


Thr Thr Lys Glu Gly Leu Arg Ala Ile Ser Asp Val Ser Asp Leu Glu 
        275                 280                 285             


Glu Thr Thr Thr Leu Ala Ser Phe Ile Ser Glu Val Val Ser Ser Ala 
    290                 295                 300                 


Pro Tyr Trp Gly Trp Ala Ile Ile Lys Ser Tyr Asp Leu Asp Pro Gly 
305                 310                 315                 320 


Ala Gly Ser Leu Glu Ile 
                325     


<210>  980
<211>  181
<212>  PRT
<213>  Homo Sapiens

<400>  980

Met Ile Ser Pro Val Leu Ile Leu Phe Ser Ser Phe Leu Cys His Val 
1               5                   10                  15      


Ala Ile Ala Gly Arg Thr Cys Pro Lys Pro Asp Asp Leu Pro Phe Ser 
            20                  25                  30          


Thr Val Val Pro Leu Lys Thr Phe Tyr Glu Pro Gly Glu Glu Ile Thr 
        35                  40                  45              


Tyr Ser Cys Lys Pro Gly Tyr Val Ser Arg Gly Gly Met Arg Lys Phe 
    50                  55                  60                  


Ile Cys Pro Leu Thr Gly Leu Trp Pro Ile Asn Thr Leu Lys Cys Thr 
65                  70                  75                  80  


Pro Arg Val Cys Pro Phe Ala Gly Ile Leu Glu Asn Gly Ala Val Arg 
                85                  90                  95      


Tyr Thr Thr Phe Glu Tyr Pro Asn Thr Ile Ser Phe Ser Cys Asn Thr 
            100                 105                 110         


Gly Phe Tyr Leu Asn Gly Ala Asp Ser Ala Lys Cys Thr Glu Glu Gly 
        115                 120                 125             


Lys Trp Ser Pro Glu Leu Pro Val Cys Ala Pro Ile Ile Cys Pro Pro 
    130                 135                 140                 


Pro Ser Ile Pro Thr Phe Ala Thr Leu Arg Val Tyr Lys Pro Ser Ala 
145                 150                 155                 160 


Gly Asn Asn Ser Leu Tyr Arg Asp Thr Ala Val Phe Glu Cys Leu Pro 
                165                 170                 175     


Gln His Ala Met Phe 
            180     


<210>  981
<211>  345
<212>  PRT
<213>  Homo Sapiens

<400>  981

Met Ile Ser Pro Val Leu Ile Leu Phe Ser Ser Phe Leu Cys His Val 
1               5                   10                  15      


Ala Ile Ala Gly Arg Thr Cys Pro Lys Pro Asp Asp Leu Pro Phe Ser 
            20                  25                  30          


Thr Val Val Pro Leu Lys Thr Phe Tyr Glu Pro Gly Glu Glu Ile Thr 
        35                  40                  45              


Tyr Ser Cys Lys Pro Gly Tyr Val Ser Arg Gly Gly Met Arg Lys Phe 
    50                  55                  60                  


Ile Cys Pro Leu Thr Gly Leu Trp Pro Ile Asn Thr Leu Lys Cys Thr 
65                  70                  75                  80  


Pro Arg Val Cys Pro Phe Ala Gly Ile Leu Glu Asn Gly Ala Val Arg 
                85                  90                  95      


Tyr Thr Thr Phe Glu Tyr Pro Asn Thr Ile Ser Phe Ser Cys Asn Thr 
            100                 105                 110         


Gly Phe Tyr Leu Asn Gly Ala Asp Ser Ala Lys Cys Thr Glu Glu Gly 
        115                 120                 125             


Lys Trp Ser Pro Glu Leu Pro Val Cys Ala Pro Ile Ile Cys Pro Pro 
    130                 135                 140                 


Pro Ser Ile Pro Thr Phe Ala Thr Leu Arg Val Tyr Lys Pro Ser Ala 
145                 150                 155                 160 


Gly Asn Asn Ser Leu Tyr Arg Asp Thr Ala Val Phe Glu Cys Leu Pro 
                165                 170                 175     


Gln His Ala Met Phe Gly Asn Asp Thr Ile Thr Cys Thr Thr His Gly 
            180                 185                 190         


Asn Trp Thr Lys Leu Pro Glu Cys Arg Glu Val Lys Cys Pro Phe Pro 
        195                 200                 205             


Ser Arg Pro Asp Asn Gly Phe Val Asn Tyr Pro Ala Lys Pro Thr Leu 
    210                 215                 220                 


Tyr Tyr Lys Asp Lys Ala Thr Phe Gly Cys His Asp Gly Tyr Ser Leu 
225                 230                 235                 240 


Asp Gly Pro Glu Glu Ile Glu Cys Thr Lys Leu Gly Asn Trp Ser Ala 
                245                 250                 255     


Met Pro Ser Cys Lys Ala Ser Cys Lys Val Pro Val Lys Lys Ala Thr 
            260                 265                 270         


Val Val Tyr Gln Gly Glu Arg Val Lys Ile Gln Glu Lys Phe Lys Asn 
        275                 280                 285             


Gly Met Leu His Gly Asp Lys Val Ser Phe Phe Cys Lys Asn Lys Glu 
    290                 295                 300                 


Lys Lys Cys Ser Tyr Thr Glu Asp Ala Gln Cys Ile Asp Gly Thr Ile 
305                 310                 315                 320 


Glu Val Pro Lys Cys Phe Lys Glu His Ser Ser Leu Ala Phe Trp Lys 
                325                 330                 335     


Thr Asp Ala Ser Asp Val Lys Pro Cys 
            340                 345 


<210>  982
<211>  200
<212>  PRT
<213>  Homo Sapiens

<400>  982

Met Arg Lys Phe Ile Cys Pro Leu Thr Gly Leu Trp Pro Ile Asn Thr 
1               5                   10                  15      


Leu Lys Cys Thr Pro Arg Val Cys Pro Phe Ala Gly Ile Leu Glu Asn 
            20                  25                  30          


Gly Ala Val Arg Tyr Thr Thr Phe Glu Tyr Pro Asn Thr Ile Ser Phe 
        35                  40                  45              


Ser Cys Asn Thr Gly Phe Tyr Leu Asn Gly Ala Asp Ser Ala Lys Cys 
    50                  55                  60                  


Thr Glu Glu Gly Lys Trp Ser Pro Glu Leu Pro Val Cys Ala Pro Ile 
65                  70                  75                  80  


Ile Cys Pro Pro Pro Ser Ile Pro Thr Phe Ala Thr Leu Arg Val Tyr 
                85                  90                  95      


Lys Pro Ser Ala Gly Asn Asn Ser Leu Tyr Arg Asp Thr Ala Val Phe 
            100                 105                 110         


Glu Cys Leu Pro Gln His Ala Met Phe Gly Asn Asp Thr Ile Thr Cys 
        115                 120                 125             


Thr Thr His Gly Asn Trp Thr Lys Leu Pro Glu Cys Arg Glu Val Lys 
    130                 135                 140                 


Cys Pro Phe Pro Ser Arg Pro Asp Asn Gly Phe Val Asn Tyr Pro Ala 
145                 150                 155                 160 


Lys Pro Thr Leu Tyr Tyr Lys Asp Lys Ala Thr Phe Gly Cys His Asp 
                165                 170                 175     


Gly Tyr Ser Leu Asp Gly Pro Glu Glu Ile Glu Cys Thr Lys Leu Gly 
            180                 185                 190         


Asn Trp Ser Ala Met Pro Ser Cys 
        195                 200 


<210>  983
<211>  104
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  983

Xaa Gln His Ala Met Phe Gly Asn Asp Thr Ile Thr Cys Thr Thr His 
1               5                   10                  15      


Gly Asn Trp Thr Lys Leu Pro Glu Cys Arg Glu Val Lys Cys Pro Phe 
            20                  25                  30          


Pro Ser Arg Pro Asp Asn Gly Phe Val Asn Tyr Pro Ala Lys Pro Thr 
        35                  40                  45              


Leu Tyr Tyr Lys Asp Lys Ala Thr Phe Gly Cys His Asp Gly Tyr Ser 
    50                  55                  60                  


Leu Asp Gly Pro Glu Glu Ile Glu Cys Thr Lys Leu Gly Asn Trp Ser 
65                  70                  75                  80  


Ala Met Pro Ser Cys Lys Glu His Ser Ser Leu Ala Phe Trp Lys Thr 
                85                  90                  95      


Asp Ala Ser Asp Val Lys Pro Cys 
            100                 


<210>  984
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  984

Met Glu Gly Ala Ala Leu Leu Arg Val Ser Val Leu Cys Ile Trp Met 
1               5                   10                  15      


Ser Ala Leu Phe Leu Gly Val Gly Val Arg Ala Glu Glu Ala Gly Ala 
            20                  25                  30          


Arg Val Gln Gln Asn Val Pro Ser Gly Thr Asp Thr Gly Asp Pro Gln 
        35                  40                  45              


Ser Lys Pro Leu Gly Asp Trp Ala Ala Gly Thr Met Asp Pro Glu Ser 
    50                  55                  60                  


Ser Ile Phe Ile Glu Asp Ala Ile Lys Tyr Phe Lys Glu Lys Val Ser 
65                  70                  75                  80  


Thr Gln Asn Leu Leu Leu Leu Leu Thr Asp Asn Glu Ala Trp Asn Gly 
                85                  90                  95      


Phe Val Ala Ala Ala Glu Leu Pro Arg Asn Glu Ala Asp Glu Leu Arg 
            100                 105                 110         


Lys Ala Leu Asp Asn Leu Ala Arg Gln Met Ile Met Lys Asp Lys Asn 
        115                 120                 125             


Trp His Asp Lys Gly Gln Gln Tyr Arg Asn Trp Phe Leu Lys Glu Phe 
    130                 135                 140                 


Pro Arg Leu Lys Ser Glu Leu Glu Asp Asn Ile Arg Arg Leu Arg Ala 
145                 150                 155                 160 


<210>  985
<211>  398
<212>  PRT
<213>  Homo Sapiens

<400>  985

Met Glu Gly Ala Ala Leu Leu Arg Val Ser Val Leu Cys Ile Trp Met 
1               5                   10                  15      


Ser Ala Leu Phe Leu Gly Val Gly Val Arg Ala Glu Glu Ala Gly Ala 
            20                  25                  30          


Arg Val Gln Gln Asn Val Pro Ser Gly Thr Asp Thr Gly Asp Pro Gln 
        35                  40                  45              


Ser Lys Pro Leu Gly Asp Trp Ala Ala Gly Thr Met Asp Pro Glu Ser 
    50                  55                  60                  


Ser Ile Phe Ile Glu Asp Ala Ile Lys Tyr Phe Lys Glu Lys Val Ser 
65                  70                  75                  80  


Thr Gln Asn Leu Leu Leu Leu Leu Thr Asp Asn Glu Ala Trp Asn Gly 
                85                  90                  95      


Phe Val Ala Ala Ala Glu Leu Pro Arg Asn Glu Ala Asp Glu Leu Arg 
            100                 105                 110         


Lys Ala Leu Asp Asn Leu Ala Arg Gln Met Ile Met Lys Asp Lys Asn 
        115                 120                 125             


Trp His Asp Lys Gly Gln Gln Tyr Arg Asn Trp Phe Leu Lys Glu Phe 
    130                 135                 140                 


Pro Arg Leu Lys Ser Glu Leu Glu Asp Asn Ile Arg Arg Leu Arg Ala 
145                 150                 155                 160 


Leu Ala Asp Gly Val Gln Lys Val His Lys Gly Thr Thr Ile Ala Asn 
                165                 170                 175     


Val Val Ser Gly Ser Leu Ser Ile Ser Ser Gly Ile Leu Thr Leu Val 
            180                 185                 190         


Gly Met Gly Leu Ala Pro Phe Thr Glu Gly Gly Ser Leu Val Leu Leu 
        195                 200                 205             


Glu Pro Gly Met Glu Leu Gly Ile Thr Ala Ala Leu Thr Gly Ile Thr 
    210                 215                 220                 


Ser Ser Thr Met Asp Tyr Gly Lys Lys Trp Trp Thr Gln Ala Gln Ala 
225                 230                 235                 240 


His Asp Leu Val Ile Lys Ser Leu Asp Lys Leu Lys Glu Val Arg Glu 
                245                 250                 255     


Phe Leu Gly Glu Asn Ile Ser Asn Phe Leu Ser Leu Ala Gly Asn Thr 
            260                 265                 270         


Tyr Gln Leu Thr Arg Gly Ile Gly Lys Asp Ile Arg Ala Leu Arg Arg 
        275                 280                 285             


Ala Arg Ala Asn Leu Gln Ser Val Pro His Ala Ser Ala Ser Arg Pro 
    290                 295                 300                 


Arg Val Thr Glu Pro Ile Ser Ala Glu Ser Gly Glu Gln Val Glu Arg 
305                 310                 315                 320 


Val Asn Glu Pro Ser Ile Leu Glu Met Ser Arg Gly Val Lys Leu Thr 
                325                 330                 335     


Asp Val Ala Pro Val Ser Phe Phe Leu Val Leu Asp Val Val Tyr Leu 
            340                 345                 350         


Val Tyr Glu Ser Lys His Leu His Glu Gly Ala Lys Ser Glu Thr Ala 
        355                 360                 365             


Glu Glu Leu Lys Lys Val Ala Gln Glu Leu Glu Glu Lys Leu Asn Ile 
    370                 375                 380                 


Leu Asn Asn Asn Tyr Lys Ile Leu Gln Ala Asp Gln Glu Leu 
385                 390                 395             


<210>  986
<211>  398
<212>  PRT
<213>  Homo Sapiens

<400>  986

Met Glu Gly Ala Ala Leu Leu Arg Val Ser Val Leu Cys Ile Trp Met 
1               5                   10                  15      


Ser Ala Leu Phe Leu Gly Val Gly Val Arg Ala Glu Glu Ala Gly Ala 
            20                  25                  30          


Arg Val Gln Gln Asn Val Pro Ser Gly Thr Asp Thr Gly Asp Pro Gln 
        35                  40                  45              


Ser Lys Pro Leu Gly Asp Trp Ala Ala Gly Thr Met Asp Pro Glu Ser 
    50                  55                  60                  


Ser Ile Phe Ile Glu Asp Ala Ile Lys Tyr Phe Lys Glu Lys Val Ser 
65                  70                  75                  80  


Thr Gln Asn Leu Leu Leu Leu Leu Thr Asp Asn Glu Ala Trp Asn Gly 
                85                  90                  95      


Phe Val Ala Ala Ala Glu Leu Pro Arg Asn Glu Ala Asp Glu Leu Arg 
            100                 105                 110         


Lys Ala Leu Asp Asn Leu Ala Arg Gln Met Ile Met Lys Asp Lys Asn 
        115                 120                 125             


Trp His Asp Lys Gly Gln Gln Tyr Arg Asn Trp Phe Leu Lys Glu Phe 
    130                 135                 140                 


Pro Arg Leu Lys Ser Glu Leu Glu Asp Asn Ile Arg Arg Leu Arg Ala 
145                 150                 155                 160 


Leu Ala Asp Gly Val Gln Lys Val His Lys Gly Thr Thr Ile Ala Asn 
                165                 170                 175     


Val Val Ser Gly Ser Leu Ser Ile Ser Ser Gly Ile Leu Thr Leu Val 
            180                 185                 190         


Gly Met Gly Leu Ala Pro Phe Thr Glu Gly Gly Ser Leu Val Leu Leu 
        195                 200                 205             


Glu Pro Gly Met Glu Leu Gly Ile Thr Ala Ala Leu Thr Gly Ile Thr 
    210                 215                 220                 


Ser Ser Thr Met Asp Tyr Gly Lys Lys Trp Trp Thr Gln Ala Gln Ala 
225                 230                 235                 240 


His Asp Leu Val Ile Lys Ser Leu Asp Lys Leu Lys Glu Val Arg Glu 
                245                 250                 255     


Phe Leu Gly Glu Asn Ile Ser Asn Phe Leu Ser Leu Ala Gly Asn Thr 
            260                 265                 270         


Tyr Gln Leu Thr Arg Gly Ile Gly Lys Asp Ile Arg Ala Leu Arg Arg 
        275                 280                 285             


Ala Arg Ala Asn Leu Gln Ser Val Pro His Ala Ser Ala Ser Arg Pro 
    290                 295                 300                 


Arg Val Thr Glu Pro Ile Ser Ala Glu Ser Gly Glu Gln Val Glu Arg 
305                 310                 315                 320 


Val Asn Glu Pro Ser Ile Leu Glu Met Ser Arg Gly Val Lys Leu Thr 
                325                 330                 335     


Asp Val Ala Pro Val Ser Phe Phe Leu Val Leu Asp Val Val Tyr Leu 
            340                 345                 350         


Val Tyr Glu Ser Lys His Leu His Glu Gly Ala Lys Ser Glu Thr Ala 
        355                 360                 365             


Glu Glu Leu Lys Lys Val Ala Gln Glu Leu Glu Glu Lys Leu Asn Ile 
    370                 375                 380                 


Leu Asn Asn Asn Tyr Lys Ile Leu Gln Ala Asp Gln Glu Leu 
385                 390                 395             


<210>  987
<211>  398
<212>  PRT
<213>  Homo Sapiens

<400>  987

Met Glu Gly Ala Ala Leu Leu Arg Val Ser Val Leu Cys Ile Trp Met 
1               5                   10                  15      


Ser Ala Leu Phe Leu Gly Val Gly Val Arg Ala Glu Glu Ala Gly Ala 
            20                  25                  30          


Arg Val Gln Gln Asn Val Pro Ser Gly Thr Asp Thr Gly Asp Pro Gln 
        35                  40                  45              


Ser Lys Pro Leu Gly Asp Trp Ala Ala Gly Thr Met Asp Pro Glu Ser 
    50                  55                  60                  


Ser Ile Phe Ile Glu Asp Ala Ile Lys Tyr Phe Lys Glu Lys Val Ser 
65                  70                  75                  80  


Thr Gln Asn Leu Leu Leu Leu Leu Thr Asp Asn Glu Ala Trp Asn Gly 
                85                  90                  95      


Phe Val Ala Ala Ala Glu Leu Pro Arg Asn Glu Ala Asp Glu Leu Arg 
            100                 105                 110         


Lys Ala Leu Asp Asn Leu Ala Arg Gln Met Ile Met Lys Asp Lys Asn 
        115                 120                 125             


Trp His Asp Lys Gly Gln Gln Tyr Arg Asn Trp Phe Leu Lys Glu Phe 
    130                 135                 140                 


Pro Arg Leu Lys Ser Glu Leu Glu Asp Asn Ile Arg Arg Leu Arg Ala 
145                 150                 155                 160 


Leu Ala Asp Gly Val Gln Lys Val His Lys Gly Thr Thr Ile Ala Asn 
                165                 170                 175     


Val Val Ser Gly Ser Leu Ser Ile Ser Ser Gly Ile Leu Thr Leu Val 
            180                 185                 190         


Gly Met Gly Leu Ala Pro Phe Thr Glu Gly Gly Ser Leu Val Leu Leu 
        195                 200                 205             


Glu Pro Gly Met Glu Leu Gly Ile Thr Ala Ala Leu Thr Gly Ile Thr 
    210                 215                 220                 


Ser Ser Thr Met Asp Tyr Gly Lys Lys Trp Trp Thr Gln Ala Gln Ala 
225                 230                 235                 240 


His Asp Leu Val Ile Lys Ser Leu Asp Lys Leu Lys Glu Val Arg Glu 
                245                 250                 255     


Phe Leu Gly Glu Asn Ile Ser Asn Phe Leu Ser Leu Ala Gly Asn Thr 
            260                 265                 270         


Tyr Gln Leu Thr Arg Gly Ile Gly Lys Asp Ile Arg Ala Leu Arg Arg 
        275                 280                 285             


Ala Arg Ala Asn Leu Gln Ser Val Pro His Ala Ser Ala Ser Arg Pro 
    290                 295                 300                 


Arg Val Thr Glu Pro Ile Ser Ala Glu Ser Gly Glu Gln Val Glu Arg 
305                 310                 315                 320 


Val Asn Glu Pro Ser Ile Leu Glu Met Ser Arg Gly Val Lys Leu Thr 
                325                 330                 335     


Asp Val Ala Pro Val Ser Phe Phe Leu Val Leu Asp Val Val Tyr Leu 
            340                 345                 350         


Val Tyr Glu Ser Lys His Leu His Glu Gly Ala Lys Ser Glu Thr Ala 
        355                 360                 365             


Glu Glu Leu Lys Lys Val Ala Gln Glu Leu Glu Glu Lys Leu Asn Ile 
    370                 375                 380                 


Leu Asn Asn Asn Tyr Lys Ile Leu Gln Ala Asp Gln Glu Leu 
385                 390                 395             


<210>  988
<211>  141
<212>  PRT
<213>  Homo Sapiens

<400>  988

Met Glu Gly Ala Ala Leu Leu Arg Val Ser Val Leu Cys Ile Trp Met 
1               5                   10                  15      


Ser Ala Leu Phe Leu Gly Val Gly Val Arg Ala Glu Glu Ala Gly Ala 
            20                  25                  30          


Arg Val Gln Gln Asn Val Pro Ser Gly Thr Asp Thr Gly Asp Pro Gln 
        35                  40                  45              


Ser Lys Pro Leu Gly Asp Trp Ala Ala Gly Thr Met Asp Pro Gly Pro 
    50                  55                  60                  


Ala Gly Ser Arg Gly Asp Ser Gly Glu Pro Cys Thr Leu Arg Pro Ala 
65                  70                  75                  80  


Cys Arg Gly Gln Arg Gln His Gly Gly Ala Ser Arg Ile Ser Ala Glu 
                85                  90                  95      


Gly Pro Ala Pro Met Pro Arg Arg Arg Thr Pro Ser Thr Ala His Leu 
            100                 105                 110         


Arg Val Pro Lys Thr Ser Arg Arg Asn Leu Leu Cys Met Arg Ala Val 
        115                 120                 125             


Ser Leu Leu Arg Met Pro Leu Ser Ile Ser Arg Lys Lys 
    130                 135                 140     


<210>  989
<211>  141
<212>  PRT
<213>  Homo Sapiens

<400>  989

Met Glu Gly Ala Ala Leu Leu Arg Val Ser Val Leu Cys Ile Trp Met 
1               5                   10                  15      


Ser Ala Leu Phe Leu Gly Val Gly Val Arg Ala Glu Glu Ala Gly Ala 
            20                  25                  30          


Arg Val Gln Gln Asn Val Pro Ser Gly Thr Asp Thr Gly Asp Pro Gln 
        35                  40                  45              


Ser Lys Pro Leu Gly Asp Trp Ala Ala Gly Thr Met Asp Pro Gly Pro 
    50                  55                  60                  


Ala Gly Ser Arg Gly Asp Ser Gly Glu Pro Cys Thr Leu Arg Pro Ala 
65                  70                  75                  80  


Cys Arg Gly Gln Arg Gln His Gly Gly Ala Ser Arg Ile Ser Ala Glu 
                85                  90                  95      


Gly Pro Ala Pro Met Pro Arg Arg Arg Thr Pro Ser Thr Ala His Leu 
            100                 105                 110         


Arg Val Pro Lys Thr Ser Arg Arg Asn Leu Leu Cys Met Arg Ala Val 
        115                 120                 125             


Ser Leu Leu Arg Met Pro Leu Ser Ile Ser Arg Lys Lys 
    130                 135                 140     


<210>  990
<211>  142
<212>  PRT
<213>  Homo Sapiens

<400>  990

Met Glu Gly Ala Ala Leu Leu Arg Val Ser Val Leu Cys Ile Trp Met 
1               5                   10                  15      


Ser Ala Leu Phe Leu Gly Val Gly Val Arg Ala Glu Glu Ala Gly Ala 
            20                  25                  30          


Arg Val Gln Gln Asn Val Pro Ser Gly Thr Asp Thr Gly Asp Pro Gln 
        35                  40                  45              


Ser Lys Pro Leu Gly Asp Trp Ala Ala Gly Thr Met Asp Pro Gly Pro 
    50                  55                  60                  


Ala Gly Ser Arg Gly Asp Ser Gly Glu Pro Cys Thr Leu Arg Pro Ala 
65                  70                  75                  80  


Cys Arg Gly Gln Arg Gln His Gly Gly Ala Ser Arg Ile Ser Ala Glu 
                85                  90                  95      


Gly Pro Ala Pro Met Pro Arg Arg Arg Thr Pro Ser Thr Ala His Leu 
            100                 105                 110         


Arg Val Pro Lys Thr Ser Arg Arg Asn Leu Leu Cys Met Val Val Val 
        115                 120                 125             


Leu Asn Ala Val Glu Phe Glu Thr Leu Phe Leu Asn Phe Lys 
    130                 135                 140         


<210>  991
<211>  380
<212>  PRT
<213>  Homo Sapiens

<400>  991

Met Glu Gly Ala Ala Leu Leu Arg Val Ser Val Leu Cys Ile Trp Val 
1               5                   10                  15      


Gln Gln Asn Val Pro Ser Gly Thr Asp Thr Gly Asp Pro Gln Ser Lys 
            20                  25                  30          


Pro Leu Gly Asp Trp Ala Ala Gly Thr Met Asp Pro Glu Ser Ser Ile 
        35                  40                  45              


Phe Ile Glu Asp Ala Ile Lys Tyr Phe Lys Glu Lys Val Ser Thr Gln 
    50                  55                  60                  


Asn Leu Leu Leu Leu Leu Thr Asp Asn Glu Ala Trp Asn Gly Phe Val 
65                  70                  75                  80  


Ala Ala Ala Glu Leu Pro Arg Asn Glu Ala Asp Glu Leu Arg Lys Ala 
                85                  90                  95      


Leu Asp Asn Leu Ala Arg Gln Met Ile Met Lys Asp Lys Asn Trp His 
            100                 105                 110         


Asp Lys Gly Gln Gln Tyr Arg Asn Trp Phe Leu Lys Glu Phe Pro Arg 
        115                 120                 125             


Leu Lys Ser Glu Leu Glu Asp Asn Ile Arg Arg Leu Arg Ala Leu Ala 
    130                 135                 140                 


Asp Gly Val Gln Lys Val His Lys Gly Thr Thr Ile Ala Asn Val Val 
145                 150                 155                 160 


Ser Gly Ser Leu Ser Ile Ser Ser Gly Ile Leu Thr Leu Val Gly Met 
                165                 170                 175     


Gly Leu Ala Pro Phe Thr Glu Gly Gly Ser Leu Val Leu Leu Glu Pro 
            180                 185                 190         


Gly Met Glu Leu Gly Ile Thr Ala Ala Leu Thr Gly Ile Thr Ser Ser 
        195                 200                 205             


Thr Met Asp Tyr Gly Lys Lys Trp Trp Thr Gln Ala Gln Ala His Asp 
    210                 215                 220                 


Leu Val Ile Lys Ser Leu Asp Lys Leu Lys Glu Val Arg Glu Phe Leu 
225                 230                 235                 240 


Gly Glu Asn Ile Ser Asn Phe Leu Ser Leu Ala Gly Asn Thr Tyr Gln 
                245                 250                 255     


Leu Thr Arg Gly Ile Gly Lys Asp Ile Arg Ala Leu Arg Arg Ala Arg 
            260                 265                 270         


Ala Asn Leu Gln Ser Val Pro His Ala Ser Ala Ser Arg Pro Arg Val 
        275                 280                 285             


Thr Glu Pro Ile Ser Ala Glu Ser Gly Glu Gln Val Glu Arg Val Asn 
    290                 295                 300                 


Glu Pro Ser Ile Leu Glu Met Ser Arg Gly Val Lys Leu Thr Asp Val 
305                 310                 315                 320 


Ala Pro Val Ser Phe Phe Leu Val Leu Asp Val Val Tyr Leu Val Tyr 
                325                 330                 335     


Glu Ser Lys His Leu His Glu Gly Ala Lys Ser Glu Thr Ala Glu Glu 
            340                 345                 350         


Leu Lys Lys Val Ala Gln Glu Leu Glu Glu Lys Leu Asn Ile Leu Asn 
        355                 360                 365             


Asn Asn Tyr Lys Ile Leu Gln Ala Asp Gln Glu Leu 
    370                 375                 380 


<210>  992
<211>  123
<212>  PRT
<213>  Homo Sapiens

<400>  992

Met Glu Gly Ala Ala Leu Leu Arg Val Ser Val Leu Cys Ile Trp Val 
1               5                   10                  15      


Gln Gln Asn Val Pro Ser Gly Thr Asp Thr Gly Asp Pro Gln Ser Lys 
            20                  25                  30          


Pro Leu Gly Asp Trp Ala Ala Gly Thr Met Asp Pro Gly Pro Ala Gly 
        35                  40                  45              


Ser Arg Gly Asp Ser Gly Glu Pro Cys Thr Leu Arg Pro Ala Cys Arg 
    50                  55                  60                  


Gly Gln Arg Gln His Gly Gly Ala Ser Arg Ile Ser Ala Glu Gly Pro 
65                  70                  75                  80  


Ala Pro Met Pro Arg Arg Arg Thr Pro Ser Thr Ala His Leu Arg Val 
                85                  90                  95      


Pro Lys Thr Ser Arg Arg Asn Leu Leu Cys Met Arg Ala Val Ser Leu 
            100                 105                 110         


Leu Arg Met Pro Leu Ser Ile Ser Arg Lys Lys 
        115                 120             


<210>  993
<211>  414
<212>  PRT
<213>  Homo Sapiens

<400>  993

Met Arg Phe Lys Ser His Thr Val Glu Leu Arg Arg Pro Cys Ser Asp 
1               5                   10                  15      


Met Glu Gly Ala Ala Leu Leu Arg Val Ser Val Leu Cys Ile Trp Met 
            20                  25                  30          


Ser Ala Leu Phe Leu Gly Val Gly Val Arg Ala Glu Glu Ala Gly Ala 
        35                  40                  45              


Arg Val Gln Gln Asn Val Pro Ser Gly Thr Asp Thr Gly Asp Pro Gln 
    50                  55                  60                  


Ser Lys Pro Leu Gly Asp Trp Ala Ala Gly Thr Met Asp Pro Glu Ser 
65                  70                  75                  80  


Ser Ile Phe Ile Glu Asp Ala Ile Lys Tyr Phe Lys Glu Lys Val Ser 
                85                  90                  95      


Thr Gln Asn Leu Leu Leu Leu Leu Thr Asp Asn Glu Ala Trp Asn Gly 
            100                 105                 110         


Phe Val Ala Ala Ala Glu Leu Pro Arg Asn Glu Ala Asp Glu Leu Arg 
        115                 120                 125             


Lys Ala Leu Asp Asn Leu Ala Arg Gln Met Ile Met Lys Asp Lys Asn 
    130                 135                 140                 


Trp His Asp Lys Gly Gln Gln Tyr Arg Asn Trp Phe Leu Lys Glu Phe 
145                 150                 155                 160 


Pro Arg Leu Lys Ser Glu Leu Glu Asp Asn Ile Arg Arg Leu Arg Ala 
                165                 170                 175     


Leu Ala Asp Gly Val Gln Lys Val His Lys Gly Thr Thr Ile Ala Asn 
            180                 185                 190         


Val Val Ser Gly Ser Leu Ser Ile Ser Ser Gly Ile Leu Thr Leu Val 
        195                 200                 205             


Gly Met Gly Leu Ala Pro Phe Thr Glu Gly Gly Ser Leu Val Leu Leu 
    210                 215                 220                 


Glu Pro Gly Met Glu Leu Gly Ile Thr Ala Ala Leu Thr Gly Ile Thr 
225                 230                 235                 240 


Ser Ser Thr Met Asp Tyr Gly Lys Lys Trp Trp Thr Gln Ala Gln Ala 
                245                 250                 255     


His Asp Leu Val Ile Lys Ser Leu Asp Lys Leu Lys Glu Val Arg Glu 
            260                 265                 270         


Phe Leu Gly Glu Asn Ile Ser Asn Phe Leu Ser Leu Ala Gly Asn Thr 
        275                 280                 285             


Tyr Gln Leu Thr Arg Gly Ile Gly Lys Asp Ile Arg Ala Leu Arg Arg 
    290                 295                 300                 


Ala Arg Ala Asn Leu Gln Ser Val Pro His Ala Ser Ala Ser Arg Pro 
305                 310                 315                 320 


Arg Val Thr Glu Pro Ile Ser Ala Glu Ser Gly Glu Gln Val Glu Arg 
                325                 330                 335     


Val Asn Glu Pro Ser Ile Leu Glu Met Ser Arg Gly Val Lys Leu Thr 
            340                 345                 350         


Asp Val Ala Pro Val Ser Phe Phe Leu Val Leu Asp Val Val Tyr Leu 
        355                 360                 365             


Val Tyr Glu Ser Lys His Leu His Glu Gly Ala Lys Ser Glu Thr Ala 
    370                 375                 380                 


Glu Glu Leu Lys Lys Val Ala Gln Glu Leu Glu Glu Lys Leu Asn Ile 
385                 390                 395                 400 


Leu Asn Asn Asn Tyr Lys Ile Leu Gln Ala Asp Gln Glu Leu 
                405                 410                 


<210>  994
<211>  118
<212>  PRT
<213>  Homo Sapiens

<400>  994

Met Arg Phe Lys Ser His Thr Val Glu Leu Arg Ser Thr Leu Ser Gln 
1               5                   10                  15      


Pro Leu Phe Ser Cys Ser Arg Arg Arg Pro Cys Ser Asp Met Glu Gly 
            20                  25                  30          


Ala Ala Leu Leu Arg Val Ser Val Leu Cys Ile Trp Met Ser Ala Leu 
        35                  40                  45              


Phe Leu Gly Val Gly Val Arg Ala Glu Glu Ala Gly Ala Arg Val Gln 
    50                  55                  60                  


Gln Asn Val Pro Ser Gly Thr Asp Thr Gly Asp Pro Gln Ser Lys Pro 
65                  70                  75                  80  


Leu Gly Asp Trp Ala Ala Gly Thr Met Asp Pro Glu Ser Ser Ile Phe 
                85                  90                  95      


Ile Glu Asp Ala Ile Lys Tyr Phe Lys Glu Lys Val Ser Thr Gln Asn 
            100                 105                 110         


Leu Leu Leu Leu Leu Thr 
        115             


<210>  995
<211>  331
<212>  PRT
<213>  Homo Sapiens

<400>  995

Met Asp Ser Glu Lys Lys Arg Phe Thr Glu Glu Ala Thr Lys Tyr Phe 
1               5                   10                  15      


Arg Glu Arg Val Ser Pro Val His Leu Gln Ile Leu Leu Thr Asn Asn 
            20                  25                  30          


Glu Ala Trp Lys Arg Phe Val Thr Ala Ala Glu Leu Pro Arg Asp Glu 
        35                  40                  45              


Ala Asp Ala Leu Tyr Glu Ala Leu Lys Lys Leu Arg Thr Tyr Ala Ala 
    50                  55                  60                  


Ile Glu Asp Glu Tyr Val Gln Gln Lys Asp Glu Gln Phe Arg Glu Trp 
65                  70                  75                  80  


Phe Leu Lys Glu Phe Pro Gln Val Lys Arg Lys Ile Gln Glu Ser Ile 
                85                  90                  95      


Glu Lys Leu Arg Ala Leu Ala Asn Gly Ile Glu Glu Val His Arg Gly 
            100                 105                 110         


Cys Thr Ile Ser Asn Val Val Ser Ser Ser Thr Gly Ala Ala Ser Gly 
        115                 120                 125             


Ile Met Ser Leu Ala Gly Leu Val Leu Ala Pro Phe Thr Ala Gly Thr 
    130                 135                 140                 


Ser Leu Ala Leu Thr Ala Ala Gly Val Gly Leu Gly Ala Ala Ser Ala 
145                 150                 155                 160 


Val Thr Gly Ile Thr Thr Ser Ile Val Glu His Ser Tyr Thr Ser Ser 
                165                 170                 175     


Ala Glu Ala Glu Ala Ser Arg Leu Thr Ala Thr Ser Ile Asp Arg Leu 
            180                 185                 190         


Lys Val Phe Lys Glu Val Met Arg Asp Ile Thr Pro Asn Leu Leu Ser 
        195                 200                 205             


Leu Leu Asn Asn Tyr Tyr Glu Ala Thr Gln Thr Ile Gly Ser Glu Ile 
    210                 215                 220                 


Arg Ala Ile Arg Gln Ala Arg Ala Arg Ala Arg Leu Pro Val Thr Thr 
225                 230                 235                 240 


Trp Arg Ile Ser Ala Gly Ser Gly Gly Gln Ala Glu Arg Thr Ile Ala 
                245                 250                 255     


Gly Thr Thr Arg Ala Val Ser Arg Gly Ala Arg Ile Leu Ser Ala Thr 
            260                 265                 270         


Thr Ser Gly Ile Phe Leu Ala Leu Asp Val Val Asn Leu Val Tyr Glu 
        275                 280                 285             


Ser Lys His Leu His Glu Gly Ala Lys Ser Ala Ser Ala Glu Glu Leu 
    290                 295                 300                 


Arg Arg Gln Ala Gln Glu Leu Glu Glu Asn Leu Met Glu Leu Thr Gln 
305                 310                 315                 320 


Ile Tyr Gln Arg Leu Asn Pro Cys His Thr His 
                325                 330     


<210>  996
<211>  402
<212>  PRT
<213>  Homo Sapiens

<400>  996

Met Gly Leu Gly Gln Gly Trp Gly Trp Glu Ala Ser Cys Phe Ala Cys 
1               5                   10                  15      


Leu Ile Arg Ser Cys Cys Gln Val Val Thr Phe Thr Phe Pro Phe Gly 
            20                  25                  30          


Phe Gln Gly Ile Ser Gln Ser Leu Glu Asn Val Ser Gly Tyr Tyr Ala 
        35                  40                  45              


Asp Ala Arg Leu Glu Val Gly Ser Thr Gln Leu Arg Thr Ala Gly Ser 
    50                  55                  60                  


Cys Ser His Ser Phe Lys Arg Ser Phe Leu Glu Lys Lys Arg Phe Thr 
65                  70                  75                  80  


Glu Glu Ala Thr Lys Tyr Phe Arg Glu Arg Val Ser Pro Val His Leu 
                85                  90                  95      


Gln Ile Leu Leu Thr Asn Asn Glu Ala Trp Lys Arg Phe Val Thr Ala 
            100                 105                 110         


Ala Glu Leu Pro Arg Asp Glu Ala Asp Ala Leu Tyr Glu Ala Leu Lys 
        115                 120                 125             


Lys Leu Arg Thr Tyr Ala Ala Ile Glu Asp Glu Tyr Val Gln Gln Lys 
    130                 135                 140                 


Asp Glu Gln Phe Arg Glu Trp Phe Leu Lys Glu Phe Pro Gln Val Lys 
145                 150                 155                 160 


Arg Lys Ile Gln Glu Ser Ile Glu Lys Leu Arg Ala Leu Ala Asn Gly 
                165                 170                 175     


Ile Glu Glu Val His Arg Gly Cys Thr Ile Ser Asn Val Val Ser Ser 
            180                 185                 190         


Ser Thr Gly Ala Ala Ser Gly Ile Met Ser Leu Ala Gly Leu Val Leu 
        195                 200                 205             


Ala Pro Phe Thr Ala Gly Thr Ser Leu Ala Leu Thr Ala Ala Gly Val 
    210                 215                 220                 


Gly Leu Gly Ala Ala Ser Ala Val Thr Gly Ile Thr Thr Ser Ile Val 
225                 230                 235                 240 


Glu His Ser Tyr Thr Ser Ser Ala Glu Ala Glu Ala Ser Arg Leu Thr 
                245                 250                 255     


Ala Thr Ser Ile Asp Arg Leu Lys Val Phe Lys Glu Val Met Arg Asp 
            260                 265                 270         


Ile Thr Pro Asn Leu Leu Ser Leu Leu Asn Asn Tyr Tyr Glu Ala Thr 
        275                 280                 285             


Gln Thr Ile Gly Ser Glu Ile Arg Ala Ile Arg Gln Ala Arg Ala Arg 
    290                 295                 300                 


Ala Arg Leu Pro Val Thr Thr Trp Arg Ile Ser Ala Gly Ser Gly Gly 
305                 310                 315                 320 


Gln Ala Glu Arg Thr Ile Ala Gly Thr Thr Arg Ala Val Ser Arg Gly 
                325                 330                 335     


Ala Arg Ile Leu Ser Ala Thr Thr Ser Gly Ile Phe Leu Ala Leu Asp 
            340                 345                 350         


Val Val Asn Leu Val Tyr Glu Ser Lys His Leu His Glu Gly Ala Lys 
        355                 360                 365             


Ser Ala Ser Ala Glu Glu Leu Arg Arg Gln Ala Gln Glu Leu Glu Glu 
    370                 375                 380                 


Asn Leu Met Glu Leu Thr Gln Ile Tyr Gln Arg Leu Asn Pro Cys His 
385                 390                 395                 400 


Thr His 
        


<210>  997
<211>  97
<212>  PRT
<213>  Homo Sapiens

<400>  997

Met Gly Leu Gly Gln Gly Trp Gly Trp Glu Ala Ser Cys Phe Ala Cys 
1               5                   10                  15      


Leu Ile Arg Ser Cys Cys Gln Val Val Thr Phe Thr Phe Pro Phe Gly 
            20                  25                  30          


Phe Gln Gly Ile Ser Gln Ser Leu Glu Asn Val Ser Gly Tyr Tyr Ala 
        35                  40                  45              


Asp Ala Arg Leu Glu Val Gly Ser Thr Gln Leu Arg Thr Ala Gly Ser 
    50                  55                  60                  


Cys Ser His Ser Phe Lys Arg Ser Phe Leu Gly Leu Arg Lys Lys Thr 
65                  70                  75                  80  


Asn Pro Ser Ser Gln Val Ser Asp Trp Arg Ala Pro Trp Lys Val Ser 
                85                  90                  95      


Gln 
    


<210>  998
<211>  82
<212>  PRT
<213>  Homo Sapiens

<400>  998

Met Gly Leu Gly Gln Gly Trp Gly Trp Glu Ala Ser Cys Phe Ala Cys 
1               5                   10                  15      


Leu Ile Arg Ser Cys Cys Gln Val Val Thr Phe Thr Phe Pro Phe Gly 
            20                  25                  30          


Phe Gln Gly Ile Ser Gln Ser Leu Glu Asn Val Ser Gly Tyr Tyr Ala 
        35                  40                  45              


Asp Ala Arg Leu Glu Val Gly Ser Thr Gln Leu Arg Thr Ala Gly Ser 
    50                  55                  60                  


Cys Ser His Ser Phe Lys Arg Ser Phe Leu Gly Gln Lys Asp Pro Ala 
65                  70                  75                  80  


Leu Val 
        


<210>  999
<211>  82
<212>  PRT
<213>  Homo Sapiens

<400>  999

Met Gly Leu Gly Gln Gly Trp Gly Trp Glu Ala Ser Cys Phe Ala Cys 
1               5                   10                  15      


Leu Ile Arg Ser Cys Cys Gln Val Val Thr Phe Thr Phe Pro Phe Gly 
            20                  25                  30          


Phe Gln Gly Ile Ser Gln Ser Leu Glu Asn Val Ser Gly Tyr Tyr Ala 
        35                  40                  45              


Asp Ala Arg Leu Glu Val Gly Ser Thr Gln Leu Arg Thr Ala Gly Ser 
    50                  55                  60                  


Cys Ser His Ser Phe Lys Arg Ser Phe Leu Gly Gln Lys Asp Pro Ala 
65                  70                  75                  80  


Leu Val 
        


<210>  1000
<211>  202
<212>  PRT
<213>  Homo Sapiens

<400>  1000

Met Ser Leu Ala Gly Leu Val Leu Ala Pro Phe Thr Ala Gly Thr Ser 
1               5                   10                  15      


Leu Ala Leu Thr Ala Ala Gly Val Gly Leu Gly Ala Ala Ser Ala Val 
            20                  25                  30          


Thr Gly Ile Thr Thr Ser Ile Val Glu His Ser Tyr Thr Ser Ser Ala 
        35                  40                  45              


Glu Ala Glu Ala Ser Arg Leu Thr Ala Thr Ser Ile Asp Arg Leu Lys 
    50                  55                  60                  


Val Phe Lys Glu Val Met Arg Asp Ile Thr Pro Asn Leu Leu Ser Leu 
65                  70                  75                  80  


Leu Asn Asn Tyr Tyr Glu Ala Thr Gln Thr Ile Gly Ser Glu Ile Arg 
                85                  90                  95      


Ala Ile Arg Gln Ala Arg Ala Arg Ala Arg Leu Pro Val Thr Thr Trp 
            100                 105                 110         


Arg Ile Ser Ala Gly Ser Gly Gly Gln Ala Glu Arg Thr Ile Ala Gly 
        115                 120                 125             


Thr Thr Arg Ala Val Ser Arg Gly Ala Arg Ile Leu Ser Ala Thr Thr 
    130                 135                 140                 


Ser Gly Ile Phe Leu Ala Leu Asp Val Val Asn Leu Val Tyr Glu Ser 
145                 150                 155                 160 


Lys His Leu His Glu Gly Ala Lys Ser Ala Ser Ala Glu Glu Leu Arg 
                165                 170                 175     


Arg Gln Ala Gln Glu Leu Glu Glu Asn Leu Met Glu Leu Thr Gln Ile 
            180                 185                 190         


Tyr Gln Arg Leu Asn Pro Cys His Thr His 
        195                 200         


<210>  1001
<211>  202
<212>  PRT
<213>  Homo Sapiens

<400>  1001

Met Ser Leu Ala Gly Leu Val Leu Ala Pro Phe Thr Ala Gly Thr Ser 
1               5                   10                  15      


Leu Ala Leu Thr Ala Ala Gly Val Gly Leu Gly Ala Ala Ser Ala Val 
            20                  25                  30          


Thr Gly Ile Thr Thr Ser Ile Val Glu His Ser Tyr Thr Ser Ser Ala 
        35                  40                  45              


Glu Ala Glu Ala Ser Arg Leu Thr Ala Thr Ser Ile Asp Arg Leu Lys 
    50                  55                  60                  


Val Phe Lys Glu Val Met Arg Asp Ile Thr Pro Asn Leu Leu Ser Leu 
65                  70                  75                  80  


Leu Asn Asn Tyr Tyr Glu Ala Thr Gln Thr Ile Gly Ser Glu Ile Arg 
                85                  90                  95      


Ala Ile Arg Gln Ala Arg Ala Arg Ala Arg Leu Pro Val Thr Thr Trp 
            100                 105                 110         


Arg Ile Ser Ala Gly Ser Gly Gly Gln Ala Glu Arg Thr Ile Ala Gly 
        115                 120                 125             


Thr Thr Arg Ala Val Ser Arg Gly Ala Arg Ile Leu Ser Ala Thr Thr 
    130                 135                 140                 


Ser Gly Ile Phe Leu Ala Leu Asp Val Val Asn Leu Val Tyr Glu Ser 
145                 150                 155                 160 


Lys His Leu His Glu Gly Ala Lys Ser Ala Ser Ala Glu Glu Leu Arg 
                165                 170                 175     


Arg Gln Ala Gln Glu Leu Glu Glu Asn Leu Met Glu Leu Thr Gln Ile 
            180                 185                 190         


Tyr Gln Arg Leu Asn Pro Cys His Thr His 
        195                 200         


<210>  1002
<211>  202
<212>  PRT
<213>  Homo Sapiens

<400>  1002

Met Ser Leu Ala Gly Leu Val Leu Ala Pro Phe Thr Ala Gly Thr Ser 
1               5                   10                  15      


Leu Ala Leu Thr Ala Ala Gly Val Gly Leu Gly Ala Ala Ser Ala Val 
            20                  25                  30          


Thr Gly Ile Thr Thr Ser Ile Val Glu His Ser Tyr Thr Ser Ser Ala 
        35                  40                  45              


Glu Ala Glu Ala Ser Arg Leu Thr Ala Thr Ser Ile Asp Arg Leu Lys 
    50                  55                  60                  


Val Phe Lys Glu Val Met Arg Asp Ile Thr Pro Asn Leu Leu Ser Leu 
65                  70                  75                  80  


Leu Asn Asn Tyr Tyr Glu Ala Thr Gln Thr Ile Gly Ser Glu Ile Arg 
                85                  90                  95      


Ala Ile Arg Gln Ala Arg Ala Arg Ala Arg Leu Pro Val Thr Thr Trp 
            100                 105                 110         


Arg Ile Ser Ala Gly Ser Gly Gly Gln Ala Glu Arg Thr Ile Ala Gly 
        115                 120                 125             


Thr Thr Arg Ala Val Ser Arg Gly Ala Arg Ile Leu Ser Ala Thr Thr 
    130                 135                 140                 


Ser Gly Ile Phe Leu Ala Leu Asp Val Val Asn Leu Val Tyr Glu Ser 
145                 150                 155                 160 


Lys His Leu His Glu Gly Ala Lys Ser Ala Ser Ala Glu Glu Leu Arg 
                165                 170                 175     


Arg Gln Ala Gln Glu Leu Glu Glu Asn Leu Met Glu Leu Thr Gln Ile 
            180                 185                 190         


Tyr Gln Arg Leu Asn Pro Cys His Thr His 
        195                 200         


<210>  1003
<211>  40
<212>  PRT
<213>  Homo Sapiens

<400>  1003

Ser Gln Ser Leu Glu Asn Val Ser Gly Tyr Tyr Ala Asp Ala Arg Leu 
1               5                   10                  15      


Glu Val Gly Ser Thr Gln Leu Arg Thr Ala Gly Ser Cys Ser His Ser 
            20                  25                  30          


Phe Lys Arg Ser Phe Leu Gly Glu 
        35                  40  


<210>  1004
<211>  39
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1004

Xaa Tyr Ala Asp Ala Arg Leu Glu Val Gly Ser Thr Gln Leu Arg Thr 
1               5                   10                  15      


Ala Gly Ser Cys Ser His Ser Phe Lys Arg Ser Phe Leu Ala Trp Leu 
            20                  25                  30          


Pro Gln Pro Pro Arg Phe Leu 
        35                  


<210>  1005
<211>  86
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1005

Xaa Tyr Ala Asp Ala Arg Leu Glu Val Gly Ser Thr Gln Leu Arg Thr 
1               5                   10                  15      


Ala Gly Ser Cys Ser His Ser Phe Lys Arg Ser Phe Leu Ala Trp Trp 
            20                  25                  30          


Tyr Val Pro Val Gly Thr Thr Thr Trp Glu Val Glu Ala Glu Ala Ser 
        35                  40                  45              


Leu Ala Ala Arg Thr Tyr Arg Gln Lys Gln Gly Gly Gln Arg Val Ser 
    50                  55                  60                  


Ser Thr Ala Pro Val Asn Ser Pro Arg Gln Thr Leu Gly His Arg Val 
65                  70                  75                  80  


Gln Asp Thr Asp Leu Glu 
                85      


<210>  1006
<211>  33
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1006

Xaa Tyr Ala Asp Ala Arg Leu Glu Val Gly Ser Thr Gln Leu Arg Thr 
1               5                   10                  15      


Ala Gly Ser Cys Ser His Ser Phe Lys Arg Ser Phe Leu Glu Met Ser 
            20                  25                  30          


Ile 
    


<210>  1007
<211>  52
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1007

Xaa Tyr Ala Asp Ala Arg Leu Glu Val Gly Ser Thr Gln Leu Arg Thr 
1               5                   10                  15      


Ala Gly Ser Cys Ser His Ser Phe Lys Arg Ser Phe Leu Gly Leu Arg 
            20                  25                  30          


Lys Lys Thr Asn Pro Ser Ser Gln Val Ser Asp Trp Arg Ala Pro Trp 
        35                  40                  45              


Lys Val Ser Gln 
    50          


<210>  1008
<211>  52
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1008

Xaa Tyr Ala Asp Ala Arg Leu Glu Val Gly Ser Thr Gln Leu Arg Thr 
1               5                   10                  15      


Ala Gly Ser Cys Ser His Ser Phe Lys Arg Ser Phe Leu Gly Leu Arg 
            20                  25                  30          


Lys Lys Thr Asn Pro Ser Ser Gln Val Ser Asp Trp Arg Ala Pro Trp 
        35                  40                  45              


Lys Val Ser Gln 
    50          


<210>  1009
<211>  37
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1009

Xaa Tyr Ala Asp Ala Arg Leu Glu Val Gly Ser Thr Gln Leu Arg Thr 
1               5                   10                  15      


Ala Gly Ser Cys Ser His Ser Phe Lys Arg Ser Phe Leu Gly Gln Lys 
            20                  25                  30          


Asp Pro Ala Leu Val 
        35          


<210>  1010
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  1010

Met Ala Ala Gly Ser Ala Pro Met Gln Leu His Leu Arg Ala Thr Ile 
1               5                   10                  15      


Arg Met Lys Asp Gly Leu Cys Val Pro Arg Lys Trp Ile Tyr His Leu 
            20                  25                  30          


Thr Glu Gly Ser Thr Asp Leu Arg Thr Glu Gly Arg Pro Asp Met Lys 
        35                  40                  45              


Thr Glu Leu Phe Ser Ser Ser Cys Pro Gly Gly Ile Met Leu Asn Glu 
    50                  55                  60                  


Thr Gly Gln Gly Tyr Gln Arg Phe Leu Leu Tyr Asn Arg Ser Pro His 
65                  70                  75                  80  


Pro Pro Glu Lys Cys Val Glu Glu Phe Lys Ser Leu Thr Ser Cys Leu 
                85                  90                  95      


Asp Ser Lys Ala Phe Leu Leu Thr Pro Arg Asn Gln Glu Ala Cys Glu 
            100                 105                 110         


Leu Ser Asn Asn 
        115     


<210>  1011
<211>  129
<212>  PRT
<213>  Homo Sapiens

<400>  1011

Met Ala Ala Gly Ser Ala Pro Met Gln Leu His Leu Arg Ala Thr Ile 
1               5                   10                  15      


Arg Met Lys Asp Gly Leu Cys Val Pro Arg Lys Trp Ile Tyr His Leu 
            20                  25                  30          


Thr Glu Gly Ser Thr Asp Leu Arg Thr Glu Gly Arg Pro Asp Met Lys 
        35                  40                  45              


Thr Glu Leu Phe Ser Ser Ser Cys Pro Gly Gly Ile Met Leu Asn Glu 
    50                  55                  60                  


Thr Gly Gln Gly Tyr Gln Arg Phe Leu Leu Tyr Asn Arg Ser Pro His 
65                  70                  75                  80  


Pro Pro Glu Lys Cys Val Glu Glu Phe Lys Ser Leu Thr Ser Cys Leu 
                85                  90                  95      


Asp Ser Lys Ala Phe Leu Leu Thr Pro Arg Asn Gln Gly Lys Gly Leu 
            100                 105                 110         


Lys Ser His Lys Thr Gly Leu Gly Leu Thr Lys Ser Ser Gly Val Thr 
        115                 120                 125             


Gly 
    


<210>  1012
<211>  188
<212>  PRT
<213>  Homo Sapiens

<400>  1012

Met Phe His Gln Ile Trp Ala Ala Leu Leu Tyr Phe Tyr Gly Ile Ile 
1               5                   10                  15      


Leu Asn Ser Ile Tyr Gln Cys Pro Glu His Ser Gln Leu Thr Thr Leu 
            20                  25                  30          


Gly Val Asp Gly Lys Glu Phe Pro Glu Val His Leu Gly Gln Trp Tyr 
        35                  40                  45              


Phe Ile Ala Gly Ala Ala Pro Thr Lys Glu Glu Leu Ala Thr Phe Asp 
    50                  55                  60                  


Pro Val Asp Asn Ile Val Phe Asn Met Ala Ala Gly Ser Ala Pro Met 
65                  70                  75                  80  


Gln Leu His Leu Arg Ala Thr Ile Arg Met Lys Asp Gly Leu Cys Val 
                85                  90                  95      


Pro Arg Lys Trp Ile Tyr His Leu Thr Glu Gly Ser Thr Asp Leu Arg 
            100                 105                 110         


Thr Glu Gly Arg Pro Asp Met Lys Thr Glu Leu Phe Ser Ser Ser Cys 
        115                 120                 125             


Pro Gly Gly Ile Met Leu Asn Glu Thr Gly Gln Gly Tyr Gln Arg Phe 
    130                 135                 140                 


Leu Leu Tyr Asn Arg Ser Pro His Pro Pro Glu Lys Cys Val Glu Glu 
145                 150                 155                 160 


Phe Lys Ser Leu Thr Ser Cys Leu Asp Ser Lys Ala Phe Leu Leu Thr 
                165                 170                 175     


Pro Arg Asn Gln Glu Ala Cys Glu Leu Ser Asn Asn 
            180                 185             


<210>  1013
<211>  268
<212>  PRT
<213>  Homo Sapiens

<400>  1013

Met Ala Ala Ile Arg Met Gly Lys Leu Thr Thr Met Pro Ala Gly Leu 
1               5                   10                  15      


Ile Tyr Ala Ser Val Ser Val His Ala Ala Lys Gln Glu Glu Ser Lys 
            20                  25                  30          


Lys Gln Leu Val Lys Pro Glu Gln Leu Pro Ile Tyr Thr Ala Pro Pro 
        35                  40                  45              


Leu Gln Ser Lys Tyr Val Glu Glu Gln Pro Gly His Leu Gln Met Gly 
    50                  55                  60                  


Phe Ala Ser Ile Arg Thr Ala Thr Gly Cys Tyr Ile Gly Trp Cys Lys 
65                  70                  75                  80  


Gly Val Tyr Val Phe Val Lys Asn Gly Ile Met Asp Thr Val Gln Phe 
                85                  90                  95      


Gly Lys Asp Ala Tyr Val Tyr Leu Lys Asn Pro Pro Arg Asp Phe Leu 
            100                 105                 110         


Pro Lys Met Gly Val Ile Thr Val Ser Gly Leu Ala Gly Leu Val Ser 
        115                 120                 125             


Ala Arg Lys Gly Ser Lys Phe Lys Lys Ile Thr Tyr Pro Leu Gly Leu 
    130                 135                 140                 


Ala Thr Leu Gly Ala Thr Val Cys Tyr Pro Val Gln Ser Val Ile Ile 
145                 150                 155                 160 


Ala Lys Val Thr Ala Lys Lys Val Tyr Ala Thr Ser Gln Gln Ile Phe 
                165                 170                 175     


Gly Ala Val Lys Ser Leu Trp Thr Lys Ser Ser Lys Glu Glu Ser Leu 
            180                 185                 190         


Pro Lys Pro Lys Glu Lys Thr Lys Leu Gly Ser Ser Ser Glu Ile Glu 
        195                 200                 205             


Val Pro Ala Lys Thr Thr His Val Leu Lys His Ser Val Pro Leu Pro 
    210                 215                 220                 


Thr Glu Leu Ser Ser Glu Ala Lys Thr Lys Ser Glu Ser Thr Ser Gly 
225                 230                 235                 240 


Ala Thr Gln Phe Met Pro Asp Pro Lys Leu Met Asp His Gly Gln Ser 
                245                 250                 255     


His Pro Glu Asp Ile Asp Met Tyr Ser Thr Arg Ser 
            260                 265             


<210>  1014
<211>  263
<212>  PRT
<213>  Homo Sapiens

<400>  1014

Met Gly Lys Leu Thr Thr Met Pro Ala Gly Leu Ile Tyr Ala Ser Val 
1               5                   10                  15      


Ser Val His Ala Ala Lys Gln Glu Glu Ser Lys Lys Gln Leu Val Lys 
            20                  25                  30          


Pro Glu Gln Leu Pro Ile Tyr Thr Ala Pro Pro Leu Gln Ser Lys Tyr 
        35                  40                  45              


Val Glu Glu Gln Pro Gly His Leu Gln Met Gly Phe Ala Ser Ile Arg 
    50                  55                  60                  


Thr Ala Thr Gly Cys Tyr Ile Gly Trp Cys Lys Gly Val Tyr Val Phe 
65                  70                  75                  80  


Val Lys Asn Gly Ile Met Asp Thr Val Gln Phe Gly Lys Asp Ala Tyr 
                85                  90                  95      


Val Tyr Leu Lys Asn Pro Pro Arg Asp Phe Leu Pro Lys Met Gly Val 
            100                 105                 110         


Ile Thr Val Ser Gly Leu Ala Gly Leu Val Ser Ala Arg Lys Gly Ser 
        115                 120                 125             


Lys Phe Lys Lys Ile Thr Tyr Pro Leu Gly Leu Ala Thr Leu Gly Ala 
    130                 135                 140                 


Thr Val Cys Tyr Pro Val Gln Ser Val Ile Ile Ala Lys Val Thr Ala 
145                 150                 155                 160 


Lys Arg Tyr Met Leu Gln Ala Ser Lys Phe Leu Glu Gln Leu Asn His 
                165                 170                 175     


Cys Gly Gln Lys Ala Ala Lys Lys Ser His Ser Leu Asn Leu Lys Lys 
            180                 185                 190         


Lys Leu Arg Leu Gly Ser Ser Ser Glu Ile Glu Val Pro Ala Lys Thr 
        195                 200                 205             


Thr His Val Leu Lys His Ser Val Pro Leu Pro Thr Glu Leu Ser Ser 
    210                 215                 220                 


Glu Ala Lys Thr Lys Ser Glu Ser Thr Ser Gly Ala Thr Gln Phe Met 
225                 230                 235                 240 


Pro Asp Pro Lys Leu Met Asp His Gly Gln Ser His Pro Glu Asp Ile 
                245                 250                 255     


Asp Met Tyr Ser Thr Arg Ser 
            260             


<210>  1015
<211>  268
<212>  PRT
<213>  Homo Sapiens

<400>  1015

Met Ser Glu Ile Lys Met Gly Lys Leu Thr Thr Met Pro Ala Gly Leu 
1               5                   10                  15      


Ile Tyr Ala Ser Val Ser Val His Ala Ala Lys Gln Glu Glu Ser Lys 
            20                  25                  30          


Lys Gln Leu Val Lys Pro Glu Gln Leu Pro Ile Tyr Thr Ala Pro Pro 
        35                  40                  45              


Leu Gln Ser Lys Tyr Val Glu Glu Gln Pro Gly His Leu Gln Met Gly 
    50                  55                  60                  


Phe Ala Ser Ile Arg Thr Ala Thr Gly Cys Tyr Ile Gly Trp Cys Lys 
65                  70                  75                  80  


Gly Val Tyr Val Phe Val Lys Asn Gly Ile Met Asp Thr Val Gln Phe 
                85                  90                  95      


Gly Lys Asp Ala Tyr Val Tyr Leu Lys Asn Pro Pro Arg Asp Phe Leu 
            100                 105                 110         


Pro Lys Met Gly Val Ile Thr Val Ser Gly Leu Ala Gly Leu Val Ser 
        115                 120                 125             


Ala Arg Lys Gly Ser Lys Phe Lys Lys Ile Thr Tyr Pro Leu Gly Leu 
    130                 135                 140                 


Ala Thr Leu Gly Ala Thr Val Cys Tyr Pro Val Gln Ser Val Ile Ile 
145                 150                 155                 160 


Ala Lys Val Thr Ala Lys Lys Val Tyr Ala Thr Ser Gln Gln Ile Phe 
                165                 170                 175     


Gly Ala Val Lys Ser Leu Trp Thr Lys Ser Ser Lys Glu Glu Ser Leu 
            180                 185                 190         


Pro Lys Pro Lys Glu Lys Thr Lys Leu Gly Ser Ser Ser Glu Ile Glu 
        195                 200                 205             


Val Pro Ala Lys Thr Thr His Val Leu Lys His Ser Val Pro Leu Pro 
    210                 215                 220                 


Thr Glu Leu Ser Ser Glu Ala Lys Thr Lys Ser Glu Ser Thr Ser Gly 
225                 230                 235                 240 


Ala Thr Gln Phe Met Pro Asp Pro Lys Leu Met Asp His Gly Gln Ser 
                245                 250                 255     


His Pro Glu Asp Ile Asp Met Tyr Ser Thr Arg Ser 
            260                 265             


<210>  1016
<211>  552
<212>  PRT
<213>  Homo Sapiens

<400>  1016

Met Ala Glu Cys Asn Leu Val Ala Ile Leu Ile Ser Ser Ile Asp Asn 
1               5                   10                  15      


Pro Leu Asp Lys Asn Leu Asp Asn Gly Gly Asn Ser Cys Leu Asp Phe 
            20                  25                  30          


Arg Pro Leu Asn Ser Phe Ser Gln Pro Gln Val Leu Leu Ala Ala Ala 
        35                  40                  45              


Val Cys Thr Lys Ala Gly Lys Ala Ile Val Ser Arg Gln Phe Val Glu 
    50                  55                  60                  


Met Thr Arg Thr Arg Ile Glu Gly Leu Leu Ala Ala Phe Pro Lys Leu 
65                  70                  75                  80  


Met Asn Thr Gly Lys Gln His Thr Phe Val Glu Thr Glu Ser Val Arg 
                85                  90                  95      


Tyr Val Tyr Gln Pro Met Glu Lys Leu Tyr Met Val Leu Ile Thr Thr 
            100                 105                 110         


Lys Asn Ser Asn Ile Leu Glu Asp Leu Glu Thr Leu Arg Leu Phe Ser 
        115                 120                 125             


Arg Val Ile Pro Glu Tyr Cys Arg Ala Leu Glu Glu Asn Glu Ile Ser 
    130                 135                 140                 


Glu His Cys Phe Asp Leu Ile Phe Ala Phe Asp Glu Ile Val Ala Leu 
145                 150                 155                 160 


Gly Tyr Arg Glu Asn Val Asn Leu Ala Gln Ile Arg Thr Phe Thr Glu 
                165                 170                 175     


Met Asp Ser His Glu Glu Lys Val Phe Arg Ala Val Arg Glu Thr Gln 
            180                 185                 190         


Glu Arg Glu Ala Lys Ala Glu Met Arg Arg Lys Ala Lys Glu Leu Gln 
        195                 200                 205             


Gln Ala Arg Arg Asp Ala Glu Arg Gln Gly Lys Lys Ala Pro Gly Phe 
    210                 215                 220                 


Gly Gly Phe Gly Ser Ser Ala Val Ser Gly Gly Ser Thr Ala Ala Met 
225                 230                 235                 240 


Ile Thr Glu Thr Ile Ile Glu Thr Asp Lys Pro Lys Val Ala Pro Ala 
                245                 250                 255     


Pro Ala Arg Pro Ser Gly Pro Ser Lys Ala Leu Lys Leu Gly Ala Lys 
            260                 265                 270         


Gly Lys Glu Val Asp Asn Phe Val Asp Lys Leu Lys Ser Glu Gly Glu 
        275                 280                 285             


Thr Ile Met Ser Ser Ser Met Gly Lys Arg Thr Ser Glu Ala Thr Lys 
    290                 295                 300                 


Met His Ala Pro Pro Ile Asn Met Glu Ser Val His Met Lys Ile Glu 
305                 310                 315                 320 


Glu Lys Ile Thr Leu Thr Cys Gly Arg Asp Gly Gly Leu Gln Asn Met 
                325                 330                 335     


Glu Leu His Gly Met Ile Met Leu Arg Ile Ser Asp Asp Lys Tyr Gly 
            340                 345                 350         


Arg Ile Arg Leu His Val Glu Asn Glu Asp Lys Lys Gly Val Gln Leu 
        355                 360                 365             


Gln Thr His Pro Asn Val Asp Lys Lys Leu Phe Thr Ala Glu Ser Leu 
    370                 375                 380                 


Ile Gly Leu Lys Asn Pro Glu Lys Ser Phe Pro Val Asn Ser Asp Val 
385                 390                 395                 400 


Gly Val Leu Lys Trp Arg Leu Gln Thr Thr Glu Glu Ser Phe Ile Pro 
                405                 410                 415     


Leu Thr Ile Asn Cys Trp Pro Ser Glu Ser Gly Asn Gly Cys Asp Val 
            420                 425                 430         


Asn Ile Glu Tyr Glu Leu Gln Glu Asp Asn Leu Glu Leu Asn Asp Val 
        435                 440                 445             


Val Ile Thr Ile Pro Leu Pro Ser Gly Val Gly Ala Pro Val Ile Gly 
    450                 455                 460                 


Glu Ile Asp Gly Glu Tyr Arg His Asp Ser Arg Arg Asn Thr Leu Glu 
465                 470                 475                 480 


Trp Cys Leu Pro Val Ile Asp Ala Lys Asn Lys Ser Gly Ser Leu Glu 
                485                 490                 495     


Phe Ser Ile Ala Gly Gln Pro Asn Asp Phe Phe Pro Val Gln Val Ser 
            500                 505                 510         


Phe Val Ser Lys Lys Asn Tyr Cys Asn Ile Gln Val Thr Lys Val Thr 
        515                 520                 525             


Gln Val Asp Gly Asn Ser Pro Val Arg Phe Ser Thr Glu Thr Thr Phe 
    530                 535                 540                 


Leu Val Asp Lys Tyr Glu Ile Leu 
545                 550         


<210>  1017
<211>  423
<212>  PRT
<213>  Homo Sapiens

<400>  1017

Met Ile Pro Glu Tyr Cys Arg Ala Leu Glu Glu Asn Glu Ile Ser Glu 
1               5                   10                  15      


His Cys Phe Asp Leu Ile Phe Ala Phe Asp Glu Ile Val Ala Leu Gly 
            20                  25                  30          


Tyr Arg Glu Asn Val Asn Leu Ala Gln Ile Arg Thr Phe Thr Glu Met 
        35                  40                  45              


Asp Ser His Glu Glu Lys Val Phe Arg Ala Val Arg Glu Thr Gln Glu 
    50                  55                  60                  


Arg Glu Ala Lys Ala Glu Met Arg Arg Lys Ala Lys Glu Leu Gln Gln 
65                  70                  75                  80  


Ala Arg Arg Asp Ala Glu Arg Gln Gly Lys Lys Ala Pro Gly Phe Gly 
                85                  90                  95      


Gly Phe Gly Ser Ser Ala Val Ser Gly Gly Ser Thr Ala Ala Met Ile 
            100                 105                 110         


Thr Glu Thr Ile Ile Glu Thr Asp Lys Pro Lys Val Ala Pro Ala Pro 
        115                 120                 125             


Ala Arg Pro Ser Gly Pro Ser Lys Ala Leu Lys Leu Gly Ala Lys Gly 
    130                 135                 140                 


Lys Glu Val Asp Asn Phe Val Asp Lys Leu Lys Ser Glu Gly Glu Thr 
145                 150                 155                 160 


Ile Met Ser Ser Ser Met Gly Lys Arg Thr Ser Glu Ala Thr Lys Met 
                165                 170                 175     


His Ala Pro Pro Ile Asn Met Glu Ser Val His Met Lys Ile Glu Glu 
            180                 185                 190         


Lys Ile Thr Leu Thr Cys Gly Arg Asp Gly Gly Leu Gln Asn Met Glu 
        195                 200                 205             


Leu His Gly Met Ile Met Leu Arg Ile Ser Asp Asp Lys Tyr Gly Arg 
    210                 215                 220                 


Ile Arg Leu His Val Glu Asn Glu Asp Lys Lys Gly Val Gln Leu Gln 
225                 230                 235                 240 


Thr His Pro Asn Val Asp Lys Lys Leu Phe Thr Ala Glu Ser Leu Ile 
                245                 250                 255     


Gly Leu Lys Asn Pro Glu Lys Ser Phe Pro Val Asn Ser Asp Val Gly 
            260                 265                 270         


Val Leu Lys Trp Arg Leu Gln Thr Thr Glu Glu Ser Phe Ile Pro Leu 
        275                 280                 285             


Thr Ile Asn Cys Trp Pro Ser Glu Ser Gly Asn Gly Cys Asp Val Asn 
    290                 295                 300                 


Ile Glu Tyr Glu Leu Gln Glu Asp Asn Leu Glu Leu Asn Asp Val Val 
305                 310                 315                 320 


Ile Thr Ile Pro Leu Pro Ser Gly Val Gly Ala Pro Val Ile Gly Glu 
                325                 330                 335     


Ile Asp Gly Glu Tyr Arg His Asp Ser Arg Arg Asn Thr Leu Glu Trp 
            340                 345                 350         


Cys Leu Pro Val Ile Asp Ala Lys Asn Lys Ser Gly Ser Leu Glu Phe 
        355                 360                 365             


Ser Ile Ala Gly Gln Pro Asn Asp Phe Phe Pro Val Gln Val Ser Phe 
    370                 375                 380                 


Val Ser Lys Lys Asn Tyr Cys Asn Ile Gln Val Thr Lys Val Thr Gln 
385                 390                 395                 400 


Val Asp Gly Asn Ser Pro Val Arg Phe Ser Thr Glu Thr Thr Phe Leu 
                405                 410                 415     


Val Asp Lys Tyr Glu Ile Leu 
            420             


<210>  1018
<211>  83
<212>  PRT
<213>  Homo Sapiens

<400>  1018

Met Val Leu Leu Ala Ala Ala Val Cys Thr Lys Ala Gly Lys Ala Ile 
1               5                   10                  15      


Val Ser Arg Gln Phe Val Glu Met Thr Arg Thr Arg Ile Glu Gly Leu 
            20                  25                  30          


Leu Ala Ala Phe Pro Lys Leu Met Asn Thr Gly Lys Gln His Thr Phe 
        35                  40                  45              


Val Glu Thr Glu Ser Ile Arg Met Ser Ser Val Leu Phe Pro Tyr Gln 
    50                  55                  60                  


Phe Ile Pro Ser Ser Leu Cys Gln Val Val Phe Leu Ser Gly Pro Val 
65                  70                  75                  80  


Leu Pro Val 
            


<210>  1019
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  1019

Met Val Leu Leu Ala Ala Ala Val Cys Thr Lys Ala Gly Lys Ala Ile 
1               5                   10                  15      


Val Ser Arg Gln Phe Val Glu Met Thr Arg Thr Arg Ile Glu Gly Leu 
            20                  25                  30          


Leu Ala Ala Phe Pro Lys Leu Met Asn Thr Gly Lys Gln His Thr Phe 
        35                  40                  45              


Val Glu Thr Glu Ser Val Arg Tyr Val Tyr Gln Pro Met Glu Lys Leu 
    50                  55                  60                  


Tyr Met Val Leu Ile Thr Thr Lys Asn Ser Asn Ile Leu Glu Asp Leu 
65                  70                  75                  80  


Glu Thr Leu Arg Leu Phe Ser Arg Val Ile Pro Glu Tyr Cys Arg Ala 
                85                  90                  95      


Leu Glu Glu Asn Glu Ile Ser Glu His Cys Phe Asp Leu Ile Phe Ala 
            100                 105                 110         


Phe Asp Glu Ile Val Ala Leu Gly Tyr Arg Glu Asn Val Asn Leu Ala 
        115                 120                 125             


Gln Ile Arg Thr Phe Thr Glu Met Asp Ser His Glu Glu Lys Val Phe 
    130                 135                 140                 


Arg Ala Val Arg Glu Thr Gln Glu Arg Glu Ala Lys Ala Glu Met Arg 
145                 150                 155                 160 


Arg Lys Ala Lys Glu Leu Gln Gln Ala Gln Ser Val Gly Ile Thr Gly 
                165                 170                 175     


Met Ser His His Ala Gln Leu Leu Leu Tyr Phe Asn Pro 
            180                 185                 


<210>  1020
<211>  511
<212>  PRT
<213>  Homo Sapiens

<400>  1020

Met Val Leu Leu Ala Ala Ala Val Cys Thr Lys Ala Gly Lys Ala Ile 
1               5                   10                  15      


Val Ser Arg Gln Phe Val Glu Met Thr Arg Thr Arg Ile Glu Gly Leu 
            20                  25                  30          


Leu Ala Ala Phe Pro Lys Leu Met Asn Thr Gly Lys Gln His Thr Phe 
        35                  40                  45              


Val Glu Thr Glu Ser Val Arg Tyr Val Tyr Gln Pro Met Glu Lys Leu 
    50                  55                  60                  


Tyr Met Val Leu Ile Thr Thr Lys Asn Ser Asn Ile Leu Glu Asp Leu 
65                  70                  75                  80  


Glu Thr Leu Arg Leu Phe Ser Arg Val Ile Pro Glu Tyr Cys Arg Ala 
                85                  90                  95      


Leu Glu Glu Asn Glu Ile Ser Glu His Cys Phe Asp Leu Ile Phe Ala 
            100                 105                 110         


Phe Asp Glu Ile Val Ala Leu Gly Tyr Arg Glu Asn Val Asn Leu Ala 
        115                 120                 125             


Gln Ile Arg Thr Phe Thr Glu Met Asp Ser His Glu Glu Lys Val Phe 
    130                 135                 140                 


Arg Ala Val Arg Glu Thr Gln Glu Arg Glu Ala Lys Ala Glu Met Arg 
145                 150                 155                 160 


Arg Lys Ala Lys Glu Leu Gln Gln Ala Arg Arg Asp Ala Glu Arg Gln 
                165                 170                 175     


Gly Lys Lys Ala Pro Gly Phe Gly Gly Phe Gly Ser Ser Ala Val Ser 
            180                 185                 190         


Gly Gly Ser Thr Ala Ala Met Ile Thr Glu Thr Ile Ile Glu Thr Asp 
        195                 200                 205             


Lys Pro Lys Val Ala Pro Ala Pro Ala Arg Pro Ser Gly Pro Ser Lys 
    210                 215                 220                 


Ala Leu Lys Leu Gly Ala Lys Gly Lys Glu Val Asp Asn Phe Val Asp 
225                 230                 235                 240 


Lys Leu Lys Ser Glu Gly Glu Thr Ile Met Ser Ser Ser Met Gly Lys 
                245                 250                 255     


Arg Thr Ser Glu Ala Thr Lys Met His Ala Pro Pro Ile Asn Met Glu 
            260                 265                 270         


Ser Val His Met Lys Ile Glu Glu Lys Ile Thr Leu Thr Cys Gly Arg 
        275                 280                 285             


Asp Gly Gly Leu Gln Asn Met Glu Leu His Gly Met Ile Met Leu Arg 
    290                 295                 300                 


Ile Ser Asp Asp Lys Tyr Gly Arg Ile Arg Leu His Val Glu Asn Glu 
305                 310                 315                 320 


Asp Lys Lys Gly Val Gln Leu Gln Thr His Pro Asn Val Asp Lys Lys 
                325                 330                 335     


Leu Phe Thr Ala Glu Ser Leu Ile Gly Leu Lys Asn Pro Glu Lys Ser 
            340                 345                 350         


Phe Pro Val Asn Ser Asp Val Gly Val Leu Lys Trp Arg Leu Gln Thr 
        355                 360                 365             


Thr Glu Glu Ser Phe Ile Pro Leu Thr Ile Asn Cys Trp Pro Ser Glu 
    370                 375                 380                 


Ser Gly Asn Gly Cys Asp Val Asn Ile Glu Tyr Glu Leu Gln Glu Asp 
385                 390                 395                 400 


Asn Leu Glu Leu Asn Asp Val Val Ile Thr Ile Pro Leu Pro Ser Gly 
                405                 410                 415     


Val Gly Ala Pro Val Ile Gly Glu Ile Asp Gly Glu Tyr Arg His Asp 
            420                 425                 430         


Ser Arg Arg Asn Thr Leu Glu Trp Cys Leu Pro Val Ile Asp Ala Lys 
        435                 440                 445             


Asn Lys Ser Gly Ser Leu Glu Phe Ser Ile Ala Gly Gln Pro Asn Asp 
    450                 455                 460                 


Phe Phe Pro Val Gln Val Ser Phe Val Ser Lys Lys Asn Tyr Cys Asn 
465                 470                 475                 480 


Ile Gln Val Thr Lys Val Thr Gln Val Asp Gly Asn Ser Pro Val Arg 
                485                 490                 495     


Phe Ser Thr Glu Thr Thr Phe Leu Val Asp Lys Tyr Glu Ile Leu 
            500                 505                 510     


<210>  1021
<211>  256
<212>  PRT
<213>  Homo Sapiens

<400>  1021

Met Lys Pro Ala Leu Cys Leu Val Ala Met Gly Ala Leu Val Met Asp 
1               5                   10                  15      


Ser Ser Pro Gln Cys Thr Lys Gln Leu Leu Ser Glu Arg Phe Gly Arg 
            20                  25                  30          


Gly Ser Arg Thr Val Asp Leu Glu Leu Glu Leu Gln Ile Glu Leu Leu 
        35                  40                  45              


Arg Glu Thr Lys Arg Lys Tyr Glu Ser Val Leu Gln Leu Gly Arg Ala 
    50                  55                  60                  


Leu Thr Ala His Leu Tyr Ser Leu Leu Gln Thr Gln His Ala Leu Gly 
65                  70                  75                  80  


Asp Ala Phe Ala Asp Leu Ser Gln Lys Ser Pro Glu Leu Gln Glu Glu 
                85                  90                  95      


Phe Gly Tyr Asn Ala Glu Thr Gln Lys Leu Leu Cys Lys Asn Gly Glu 
            100                 105                 110         


Thr Leu Leu Gly Ala Val Asn Phe Phe Val Ser Ser Ile Asn Thr Leu 
        115                 120                 125             


Val Thr Lys Thr Met Glu Asp Thr Leu Met Thr Val Lys Gln Tyr Glu 
    130                 135                 140                 


Ala Ala Arg Leu Glu Tyr Asp Ala Tyr Arg Thr Asp Leu Glu Glu Leu 
145                 150                 155                 160 


Ser Leu Gly Pro Arg Asp Ala Gly Thr Arg Gly Arg Leu Glu Ser Ala 
                165                 170                 175     


Gln Ala Thr Phe Gln Ala His Arg Asp Lys Tyr Glu Lys Leu Arg Gly 
            180                 185                 190         


Asp Val Ala Ile Lys Leu Lys Phe Leu Glu Glu Asn Lys Ile Lys Val 
        195                 200                 205             


Met His Lys Gln Leu Leu Leu Phe His Asn Ala Val Ser Ala Tyr Phe 
    210                 215                 220                 


Ala Gly Asn Gln Lys Gln Leu Glu Gln Thr Leu Gln Gln Phe Asn Ile 
225                 230                 235                 240 


Lys Leu Arg Pro Pro Gly Ala Glu Lys Pro Ser Trp Leu Glu Glu Gln 
                245                 250                 255     


<210>  1022
<211>  374
<212>  PRT
<213>  Homo Sapiens

<400>  1022

Met Thr Asp Gly Ile Leu Gly Lys Ala Ala Thr Met Glu Ile Pro Ile 
1               5                   10                  15      


His Gly Asn Gly Glu Ala Arg Gln Leu Pro Glu Asp Asp Gly Leu Glu 
            20                  25                  30          


Gln Asp Leu Gln Gln Val Met Val Ser Gly Pro Asn Leu Asn Glu Thr 
        35                  40                  45              


Ser Ile Val Ser Gly Gly Tyr Gly Gly Ser Gly Asp Gly Leu Ile Pro 
    50                  55                  60                  


Thr Gly Lys Ser Ile Ser Cys Ala Arg Arg Glu Val Trp Val Gly Pro 
65                  70                  75                  80  


Gln Arg Cys Leu Val Tyr Leu Arg Glu Ala Gly Val Arg Glu Leu Asp 
                85                  90                  95      


Pro Leu Gly Ser Gly Arg His Pro Ser His Ser Thr Thr Pro Ser Gly 
            100                 105                 110         


Pro Gly Asp Glu Val Ala Arg Gly Ile Ala Gly Glu Lys Phe Asp Ile 
        115                 120                 125             


Val Lys Lys Trp Gly Ile Asn Thr Tyr Lys Cys Thr Lys Gln Leu Leu 
    130                 135                 140                 


Ser Glu Arg Phe Gly Arg Gly Ser Arg Thr Val Asp Leu Glu Leu Glu 
145                 150                 155                 160 


Leu Gln Ile Glu Leu Leu Arg Glu Thr Lys Arg Lys Tyr Glu Ser Val 
                165                 170                 175     


Leu Gln Leu Gly Arg Ala Leu Thr Ala His Leu Tyr Ser Leu Leu Gln 
            180                 185                 190         


Thr Gln His Ala Leu Gly Asp Ala Phe Ala Asp Leu Ser Gln Lys Ser 
        195                 200                 205             


Pro Glu Leu Gln Glu Glu Phe Gly Tyr Asn Ala Glu Thr Gln Lys Leu 
    210                 215                 220                 


Leu Cys Lys Asn Gly Glu Thr Leu Leu Gly Ala Val Asn Phe Phe Val 
225                 230                 235                 240 


Ser Ser Ile Asn Thr Leu Val Thr Lys Thr Met Glu Asp Thr Leu Met 
                245                 250                 255     


Thr Val Lys Gln Tyr Glu Ala Ala Arg Leu Glu Tyr Asp Ala Tyr Arg 
            260                 265                 270         


Thr Asp Leu Glu Glu Leu Ser Leu Gly Pro Arg Asp Ala Gly Thr Arg 
        275                 280                 285             


Gly Arg Leu Glu Ser Ala Gln Ala Thr Phe Gln Ala His Arg Asp Lys 
    290                 295                 300                 


Tyr Glu Lys Leu Arg Gly Asp Val Ala Ile Lys Leu Lys Phe Leu Glu 
305                 310                 315                 320 


Glu Asn Lys Ile Lys Val Met His Lys Gln Leu Leu Leu Phe His Asn 
                325                 330                 335     


Ala Val Ser Ala Tyr Phe Ala Gly Asn Gln Lys Gln Leu Glu Gln Thr 
            340                 345                 350         


Leu Gln Gln Phe Asn Ile Lys Leu Arg Pro Pro Gly Ala Glu Lys Pro 
        355                 360                 365             


Ser Trp Leu Glu Glu Gln 
    370                 


<210>  1023
<211>  159
<212>  PRT
<213>  Homo Sapiens

<400>  1023

Met Thr Asp Gly Ile Leu Gly Lys Ala Ala Thr Met Glu Ile Pro Ile 
1               5                   10                  15      


His Gly Asn Gly Glu Ala Arg Gln Leu Pro Glu Asp Asp Gly Leu Glu 
            20                  25                  30          


Gln Asp Leu Gln Gln Val Met Val Ser Gly Pro Asn Leu Asn Glu Thr 
        35                  40                  45              


Ser Ile Val Ser Gly Gly Tyr Gly Gly Ser Gly Asp Gly Leu Ile Pro 
    50                  55                  60                  


Thr Gly Ser Gly Arg His Pro Ser His Ser Thr Thr Pro Ser Gly Pro 
65                  70                  75                  80  


Gly Asp Glu Val Ala Arg Gly Ile Ala Gly Glu Lys Phe Asp Ile Val 
                85                  90                  95      


Lys Lys Trp Gly Ile Asn Thr Tyr Lys Cys Thr Lys Gln Leu Leu Ser 
            100                 105                 110         


Glu Arg Phe Gly Arg Gly Ser Arg Thr Val Asp Leu Glu Leu Glu Leu 
        115                 120                 125             


Gln Ile Glu Leu Leu Arg Glu Thr Lys Arg Lys Arg Asn Leu Ala Thr 
    130                 135                 140                 


Met Gln Arg His Arg Asn Tyr Tyr Ala Arg Met Gly Lys Arg Cys 
145                 150                 155                 


<210>  1024
<211>  341
<212>  PRT
<213>  Homo Sapiens

<400>  1024

Met Thr Asp Gly Ile Leu Gly Lys Ala Ala Thr Met Glu Ile Pro Ile 
1               5                   10                  15      


His Gly Asn Gly Glu Ala Arg Gln Leu Pro Glu Asp Asp Gly Leu Glu 
            20                  25                  30          


Gln Asp Leu Gln Gln Val Met Val Ser Gly Pro Asn Leu Asn Glu Thr 
        35                  40                  45              


Ser Ile Val Ser Gly Gly Tyr Gly Gly Ser Gly Asp Gly Leu Ile Pro 
    50                  55                  60                  


Thr Gly Ser Gly Arg His Pro Ser His Ser Thr Thr Pro Ser Gly Pro 
65                  70                  75                  80  


Gly Asp Glu Val Ala Arg Gly Ile Ala Gly Glu Lys Phe Asp Ile Val 
                85                  90                  95      


Lys Lys Trp Gly Ile Asn Thr Tyr Lys Cys Thr Lys Gln Leu Leu Ser 
            100                 105                 110         


Glu Arg Phe Gly Arg Gly Ser Arg Thr Val Asp Leu Glu Leu Glu Leu 
        115                 120                 125             


Gln Ile Glu Leu Leu Arg Glu Thr Lys Arg Lys Tyr Glu Ser Val Leu 
    130                 135                 140                 


Gln Leu Gly Arg Ala Leu Thr Ala His Leu Tyr Ser Leu Leu Gln Thr 
145                 150                 155                 160 


Gln His Ala Leu Gly Asp Ala Phe Ala Asp Leu Ser Gln Lys Ser Pro 
                165                 170                 175     


Glu Leu Gln Glu Glu Phe Gly Tyr Asn Ala Glu Thr Gln Lys Leu Leu 
            180                 185                 190         


Cys Lys Asn Gly Glu Thr Leu Leu Gly Ala Val Asn Phe Phe Val Ser 
        195                 200                 205             


Ser Ile Asn Thr Leu Val Thr Lys Thr Met Glu Asp Thr Leu Met Thr 
    210                 215                 220                 


Val Lys Gln Tyr Glu Ala Ala Arg Leu Glu Tyr Asp Ala Tyr Arg Thr 
225                 230                 235                 240 


Asp Leu Glu Glu Leu Ser Leu Gly Pro Arg Asp Ala Gly Thr Arg Gly 
                245                 250                 255     


Arg Leu Glu Ser Ala Gln Ala Thr Phe Gln Ala His Arg Asp Lys Tyr 
            260                 265                 270         


Glu Lys Leu Arg Gly Asp Val Ala Ile Lys Leu Lys Phe Leu Glu Glu 
        275                 280                 285             


Asn Lys Ile Lys Val Met His Lys Gln Leu Leu Leu Phe His Asn Ala 
    290                 295                 300                 


Val Ser Ala Tyr Phe Ala Gly Asn Gln Lys Gln Leu Glu Gln Thr Leu 
305                 310                 315                 320 


Gln Gln Phe Asn Ile Lys Leu Arg Pro Pro Gly Ala Glu Lys Pro Ser 
                325                 330                 335     


Trp Leu Glu Glu Gln 
            340     


<210>  1025
<211>  341
<212>  PRT
<213>  Homo Sapiens

<400>  1025

Met Thr Asp Gly Ile Leu Gly Lys Ala Ala Thr Met Glu Ile Pro Ile 
1               5                   10                  15      


His Gly Asn Gly Glu Ala Arg Gln Leu Pro Glu Asp Asp Gly Leu Glu 
            20                  25                  30          


Gln Asp Leu Gln Gln Val Met Val Ser Gly Pro Asn Leu Asn Glu Thr 
        35                  40                  45              


Ser Ile Val Ser Gly Gly Tyr Gly Gly Ser Gly Asp Gly Leu Ile Pro 
    50                  55                  60                  


Thr Gly Ser Gly Arg His Pro Ser His Ser Thr Thr Pro Ser Gly Pro 
65                  70                  75                  80  


Gly Asp Glu Val Ala Arg Gly Ile Ala Gly Glu Lys Phe Asp Ile Val 
                85                  90                  95      


Lys Lys Trp Gly Ile Asn Thr Tyr Lys Cys Thr Lys Gln Leu Leu Ser 
            100                 105                 110         


Glu Arg Phe Gly Arg Gly Ser Arg Thr Val Asp Leu Glu Leu Glu Leu 
        115                 120                 125             


Gln Ile Glu Leu Leu Arg Glu Thr Lys Arg Lys Tyr Glu Ser Val Leu 
    130                 135                 140                 


Gln Leu Gly Arg Ala Leu Thr Ala His Leu Tyr Ser Leu Leu Gln Thr 
145                 150                 155                 160 


Gln His Ala Leu Gly Asp Ala Phe Ala Asp Leu Ser Gln Lys Ser Pro 
                165                 170                 175     


Glu Leu Gln Glu Glu Phe Gly Tyr Asn Ala Glu Thr Gln Lys Leu Leu 
            180                 185                 190         


Cys Lys Asn Gly Glu Thr Leu Leu Gly Ala Val Asn Phe Phe Val Ser 
        195                 200                 205             


Ser Ile Asn Thr Leu Val Thr Lys Thr Met Glu Asp Thr Leu Met Thr 
    210                 215                 220                 


Val Lys Gln Tyr Glu Ala Ala Arg Leu Glu Tyr Asp Ala Tyr Arg Thr 
225                 230                 235                 240 


Asp Leu Glu Glu Leu Ser Leu Gly Pro Arg Asp Ala Gly Thr Arg Gly 
                245                 250                 255     


Arg Leu Glu Ser Ala Gln Ala Thr Phe Gln Ala His Arg Asp Lys Tyr 
            260                 265                 270         


Glu Lys Leu Arg Gly Asp Val Ala Ile Lys Leu Lys Phe Leu Glu Glu 
        275                 280                 285             


Asn Lys Ile Lys Val Met His Lys Gln Leu Leu Leu Phe His Asn Ala 
    290                 295                 300                 


Val Ser Ala Tyr Phe Ala Gly Asn Gln Lys Gln Leu Glu Gln Thr Leu 
305                 310                 315                 320 


Gln Gln Phe Asn Ile Lys Leu Arg Pro Pro Gly Ala Glu Lys Pro Ser 
                325                 330                 335     


Trp Leu Glu Glu Gln 
            340     


<210>  1026
<211>  202
<212>  PRT
<213>  Homo Sapiens

<400>  1026

Met Thr Asp Gly Ile Leu Gly Lys Ala Ala Thr Met Glu Ile Pro Ile 
1               5                   10                  15      


His Gly Asn Gly Glu Ala Arg Gln Leu Pro Glu Asp Asp Gly Leu Glu 
            20                  25                  30          


Gln Asp Leu Gln Gln Val Met Val Ser Gly Pro Asn Leu Asn Glu Thr 
        35                  40                  45              


Ser Ile Val Ser Gly Gly Tyr Gly Gly Ser Gly Asp Gly Leu Ile Pro 
    50                  55                  60                  


Thr Gly Ser Gly Arg His Pro Ser His Ser Thr Thr Pro Ser Gly Pro 
65                  70                  75                  80  


Gly Asp Glu Val Ala Arg Gly Ile Ala Gly Glu Lys Phe Asp Ile Val 
                85                  90                  95      


Lys Lys Trp Gly Ile Asn Thr Tyr Lys Cys Thr Lys Gln Leu Leu Ser 
            100                 105                 110         


Glu Arg Phe Gly Arg Gly Ser Arg Thr Val Asp Leu Glu Leu Glu Leu 
        115                 120                 125             


Gln Ile Glu Leu Leu Arg Glu Thr Lys Arg Lys Tyr Glu Ser Val Leu 
    130                 135                 140                 


Gln Leu Gly Arg Ala Leu Thr Ala His Leu Tyr Ser Leu Leu Gln Thr 
145                 150                 155                 160 


Gln His Ala Leu Gly Asp Ala Phe Ala Asp Leu Ser Gln Lys Ser Pro 
                165                 170                 175     


Glu Leu Gln Pro Thr Gly Arg Thr Pro Ser Gly Trp Ala Gln Pro Tyr 
            180                 185                 190         


Pro Gln Gln His Ser Pro Val Glu Ala Ala 
        195                 200         


<210>  1027
<211>  303
<212>  PRT
<213>  Homo Sapiens

<400>  1027

Met Val Ser Gly Pro Asn Leu Asn Glu Thr Ser Ile Val Ser Gly Gly 
1               5                   10                  15      


Tyr Gly Gly Ser Gly Asp Gly Leu Ile Pro Thr Gly Ser Gly Arg His 
            20                  25                  30          


Pro Ser His Ser Thr Thr Pro Ser Gly Pro Gly Asp Glu Val Ala Arg 
        35                  40                  45              


Gly Ile Ala Gly Glu Lys Phe Asp Ile Val Lys Lys Trp Gly Ile Asn 
    50                  55                  60                  


Thr Tyr Lys Cys Thr Lys Gln Leu Leu Ser Glu Arg Phe Gly Arg Gly 
65                  70                  75                  80  


Ser Arg Thr Val Asp Leu Glu Leu Glu Leu Gln Ile Glu Leu Leu Arg 
                85                  90                  95      


Glu Thr Lys Arg Lys Tyr Glu Ser Val Leu Gln Leu Gly Arg Ala Leu 
            100                 105                 110         


Thr Ala His Leu Tyr Ser Leu Leu Gln Thr Gln His Ala Leu Gly Asp 
        115                 120                 125             


Ala Phe Ala Asp Leu Ser Gln Lys Ser Pro Glu Leu Gln Glu Glu Phe 
    130                 135                 140                 


Gly Tyr Asn Ala Glu Thr Gln Lys Leu Leu Cys Lys Asn Gly Glu Thr 
145                 150                 155                 160 


Leu Leu Gly Ala Val Asn Phe Phe Val Ser Ser Ile Asn Thr Leu Val 
                165                 170                 175     


Thr Lys Thr Met Glu Asp Thr Leu Met Thr Val Lys Gln Tyr Glu Ala 
            180                 185                 190         


Ala Arg Leu Glu Tyr Asp Ala Tyr Arg Thr Asp Leu Glu Glu Leu Ser 
        195                 200                 205             


Leu Gly Pro Arg Asp Ala Gly Thr Arg Gly Arg Leu Glu Ser Ala Gln 
    210                 215                 220                 


Ala Thr Phe Gln Ala His Arg Asp Lys Tyr Glu Lys Leu Arg Gly Asp 
225                 230                 235                 240 


Val Ala Ile Lys Leu Lys Phe Leu Glu Glu Asn Lys Ile Lys Val Met 
                245                 250                 255     


His Lys Gln Leu Leu Leu Phe His Asn Ala Val Ser Ala Tyr Phe Ala 
            260                 265                 270         


Gly Asn Gln Lys Gln Leu Glu Gln Thr Leu Gln Gln Phe Asn Ile Lys 
        275                 280                 285             


Leu Arg Pro Pro Gly Ala Glu Lys Pro Ser Trp Leu Glu Glu Gln 
    290                 295                 300             


<210>  1028
<211>  535
<212>  PRT
<213>  Homo Sapiens

<400>  1028

Met Ala Trp Ile Leu Asp Cys Leu Phe Ala Ser Ala Phe Glu Pro Arg 
1               5                   10                  15      


Pro Arg Arg Val Ser Val Leu Gly Gly Ala Pro Gly His Asn Pro Asp 
            20                  25                  30          


Arg Arg Thr Lys Met Val Ser Ile His Ser Leu Ser Glu Leu Glu Arg 
        35                  40                  45              


Leu Lys Leu Gln Glu Thr Ala Tyr His Glu Leu Val Ala Arg His Phe 
    50                  55                  60                  


Leu Ser Glu Phe Lys Pro Asp Arg Ala Leu Pro Ile Asp Arg Pro Asn 
65                  70                  75                  80  


Thr Leu Asp Lys Trp Phe Leu Ile Leu Arg Gly Gln Gln Arg Ala Val 
                85                  90                  95      


Ser His Lys Thr Phe Gly Ile Ser Leu Glu Glu Val Leu Val Asn Glu 
            100                 105                 110         


Phe Thr Arg Arg Lys His Leu Glu Leu Thr Ala Thr Met Gln Val Glu 
        115                 120                 125             


Glu Ala Thr Gly Gln Ala Ala Gly Arg Arg Arg Gly Asn Val Val Arg 
    130                 135                 140                 


Arg Val Phe Gly Arg Ile Arg Arg Phe Phe Ser Arg Arg Arg Asn Glu 
145                 150                 155                 160 


Pro Thr Leu Pro Arg Glu Phe Thr Arg Arg Gly Arg Arg Gly Ala Val 
                165                 170                 175     


Ser Val Asp Ser Leu Ala Glu Leu Glu Asp Gly Ala Leu Leu Leu Gln 
            180                 185                 190         


Thr Leu Gln Leu Ser Lys Ile Ser Phe Pro Ile Gly Gln Arg Leu Leu 
        195                 200                 205             


Gly Ser Lys Arg Lys Met Ser Leu Asn Pro Ile Ala Lys Gln Ile Pro 
    210                 215                 220                 


Gln Val Val Glu Ala Cys Cys Gln Phe Ile Glu Lys His Gly Leu Ser 
225                 230                 235                 240 


Ala Val Gly Ile Phe Thr Leu Glu Tyr Ser Val Gln Arg Val Arg Gln 
                245                 250                 255     


Leu Arg Glu Glu Phe Asp Gln Gly Leu Asp Val Val Leu Asp Asp Asn 
            260                 265                 270         


Gln Asn Val His Asp Val Ala Ala Leu Leu Lys Glu Phe Phe Arg Asp 
        275                 280                 285             


Met Lys Asp Ser Leu Leu Pro Asp Asp Leu Tyr Met Ser Phe Leu Leu 
    290                 295                 300                 


Thr Ala Thr Leu Lys Pro Gln Asp Gln Leu Ser Ala Leu Gln Leu Leu 
305                 310                 315                 320 


Val Tyr Leu Met Pro Pro Cys His Ser Asp Thr Leu Glu Arg Leu Leu 
                325                 330                 335     


Lys Ala Leu His Lys Ile Thr Glu Asn Cys Glu Asp Ser Ile Gly Ile 
            340                 345                 350         


Asp Gly Gln Leu Val Pro Gly Asn Arg Met Thr Ser Thr Asn Leu Ala 
        355                 360                 365             


Leu Val Phe Gly Ser Ala Leu Leu Lys Lys Gly Lys Phe Gly Lys Arg 
    370                 375                 380                 


Glu Ser Arg Lys Thr Lys Leu Gly Ile Asp His Tyr Val Ala Ser Val 
385                 390                 395                 400 


Asn Val Val Arg Ala Met Ile Asp Asn Trp Asp Val Leu Phe Gln Val 
                405                 410                 415     


Pro Pro His Ile Gln Arg Gln Val Ala Lys Arg Val Trp Lys Ser Ser 
            420                 425                 430         


Pro Glu Ala Leu Asp Phe Ile Arg Arg Arg Asn Leu Arg Lys Ile Gln 
        435                 440                 445             


Ser Ala Arg Ile Lys Met Glu Glu Asp Ala Leu Leu Ser Asp Pro Val 
    450                 455                 460                 


Glu Thr Ser Ala Glu Ala Arg Ala Ala Val Leu Ala Gln Ser Lys Pro 
465                 470                 475                 480 


Ser Asp Glu Gly Ser Ser Glu Glu Pro Ala Val Pro Ser Gly Thr Ala 
                485                 490                 495     


Arg Ser His Asp Asp Glu Glu Gly Ala Gly Asn Pro Pro Ile Pro Glu 
            500                 505                 510         


Gln Asp Arg Pro Leu Leu Arg Val Pro Arg Glu Lys Glu Ala Lys Thr 
        515                 520                 525             


Gly Val Ser Tyr Phe Phe Pro 
    530                 535 


<210>  1029
<211>  547
<212>  PRT
<213>  Homo Sapiens

<400>  1029

Met Gly Gly Cys Ile Pro Phe Leu Lys Ala Ala Arg Ala Leu Cys Pro 
1               5                   10                  15      


Arg Ile Met Pro Pro Leu Leu Leu Leu Ser Ala Phe Ile Phe Leu Val 
            20                  25                  30          


Ser Val Leu Gly Gly Ala Pro Gly His Asn Pro Asp Arg Arg Thr Lys 
        35                  40                  45              


Met Val Ser Ile His Ser Leu Ser Glu Leu Glu Arg Leu Lys Leu Gln 
    50                  55                  60                  


Glu Thr Ala Tyr His Glu Leu Val Ala Arg His Phe Leu Ser Glu Phe 
65                  70                  75                  80  


Lys Pro Asp Arg Ala Leu Pro Ile Asp Arg Pro Asn Thr Leu Asp Lys 
                85                  90                  95      


Trp Phe Leu Ile Leu Arg Gly Gln Gln Arg Ala Val Ser His Lys Thr 
            100                 105                 110         


Phe Gly Ile Ser Leu Glu Glu Val Leu Val Asn Glu Phe Thr Arg Arg 
        115                 120                 125             


Lys His Leu Glu Leu Thr Ala Thr Met Gln Val Glu Glu Ala Thr Gly 
    130                 135                 140                 


Gln Ala Ala Gly Arg Arg Arg Gly Asn Val Val Arg Arg Val Phe Gly 
145                 150                 155                 160 


Arg Ile Arg Arg Phe Phe Ser Arg Arg Arg Asn Glu Pro Thr Leu Pro 
                165                 170                 175     


Arg Glu Phe Thr Arg Arg Gly Arg Arg Gly Ala Val Ser Val Asp Ser 
            180                 185                 190         


Leu Ala Glu Leu Glu Asp Gly Ala Leu Leu Leu Gln Thr Leu Gln Leu 
        195                 200                 205             


Ser Lys Ile Ser Phe Pro Ile Gly Gln Arg Leu Leu Gly Ser Lys Arg 
    210                 215                 220                 


Lys Met Ser Leu Asn Pro Ile Ala Lys Gln Ile Pro Gln Val Val Glu 
225                 230                 235                 240 


Ala Cys Cys Gln Phe Ile Glu Lys His Gly Leu Ser Ala Val Gly Ile 
                245                 250                 255     


Phe Thr Leu Glu Tyr Ser Val Gln Arg Val Arg Gln Leu Arg Glu Glu 
            260                 265                 270         


Phe Asp Gln Gly Leu Asp Val Val Leu Asp Asp Asn Gln Asn Val His 
        275                 280                 285             


Asp Val Ala Ala Leu Leu Lys Glu Phe Phe Arg Asp Met Lys Asp Ser 
    290                 295                 300                 


Leu Leu Pro Asp Asp Leu Tyr Met Ser Phe Leu Leu Thr Ala Thr Leu 
305                 310                 315                 320 


Lys Pro Gln Asp Gln Leu Ser Ala Leu Gln Leu Leu Val Tyr Leu Met 
                325                 330                 335     


Pro Pro Cys His Ser Asp Thr Leu Glu Arg Leu Leu Lys Ala Leu His 
            340                 345                 350         


Lys Ile Thr Glu Asn Cys Glu Asp Ser Ile Gly Ile Asp Gly Gln Leu 
        355                 360                 365             


Val Pro Gly Asn Arg Met Thr Ser Thr Asn Leu Ala Leu Val Phe Gly 
    370                 375                 380                 


Ser Ala Leu Leu Lys Lys Gly Lys Phe Gly Lys Arg Glu Ser Arg Lys 
385                 390                 395                 400 


Thr Lys Leu Gly Ile Asp His Tyr Val Ala Ser Val Asn Val Val Arg 
                405                 410                 415     


Ala Met Ile Asp Asn Trp Asp Val Leu Phe Gln Val Pro Pro His Ile 
            420                 425                 430         


Gln Arg Gln Val Ala Lys Arg Val Trp Lys Ser Ser Pro Glu Ala Leu 
        435                 440                 445             


Asp Phe Ile Arg Arg Arg Asn Leu Arg Lys Ile Gln Ser Ala Arg Ile 
    450                 455                 460                 


Lys Met Glu Glu Asp Ala Leu Leu Ser Asp Pro Val Glu Thr Ser Ala 
465                 470                 475                 480 


Glu Ala Arg Ala Ala Val Leu Ala Gln Ser Lys Pro Ser Asp Glu Gly 
                485                 490                 495     


Ser Ser Glu Glu Pro Ala Val Pro Ser Gly Thr Ala Arg Ser His Asp 
            500                 505                 510         


Asp Glu Glu Gly Ala Gly Asn Pro Pro Ile Pro Glu Gln Asp Arg Pro 
        515                 520                 525             


Leu Leu Arg Val Pro Arg Glu Lys Glu Ala Lys Thr Gly Val Ser Tyr 
    530                 535                 540                 


Phe Phe Pro 
545         


<210>  1030
<211>  411
<212>  PRT
<213>  Homo Sapiens

<400>  1030

Met Gln Val Glu Glu Ala Thr Gly Gln Ala Ala Gly Arg Arg Arg Gly 
1               5                   10                  15      


Asn Val Val Arg Arg Val Phe Gly Arg Ile Arg Arg Phe Phe Ser Arg 
            20                  25                  30          


Arg Arg Asn Glu Pro Thr Leu Pro Arg Glu Phe Thr Arg Arg Gly Arg 
        35                  40                  45              


Arg Gly Ala Val Ser Val Asp Ser Leu Ala Glu Leu Glu Asp Gly Ala 
    50                  55                  60                  


Leu Leu Leu Gln Thr Leu Gln Leu Ser Lys Ile Ser Phe Pro Ile Gly 
65                  70                  75                  80  


Gln Arg Leu Leu Gly Ser Lys Arg Lys Met Ser Leu Asn Pro Ile Ala 
                85                  90                  95      


Lys Gln Ile Pro Gln Val Val Glu Ala Cys Cys Gln Phe Ile Glu Lys 
            100                 105                 110         


His Gly Leu Ser Ala Val Gly Ile Phe Thr Leu Glu Tyr Ser Val Gln 
        115                 120                 125             


Arg Val Arg Gln Leu Arg Glu Glu Phe Asp Gln Gly Leu Asp Val Val 
    130                 135                 140                 


Leu Asp Asp Asn Gln Asn Val His Asp Val Ala Ala Leu Leu Lys Glu 
145                 150                 155                 160 


Phe Phe Arg Asp Met Lys Asp Ser Leu Leu Pro Asp Asp Leu Tyr Met 
                165                 170                 175     


Ser Phe Leu Leu Thr Ala Thr Leu Lys Pro Gln Asp Gln Leu Ser Ala 
            180                 185                 190         


Leu Gln Leu Leu Val Tyr Leu Met Pro Pro Cys His Ser Asp Thr Leu 
        195                 200                 205             


Glu Arg Leu Leu Lys Ala Leu His Lys Ile Thr Glu Asn Cys Glu Asp 
    210                 215                 220                 


Ser Ile Gly Ile Asp Gly Gln Leu Val Pro Gly Asn Arg Met Thr Ser 
225                 230                 235                 240 


Thr Asn Leu Ala Leu Val Phe Gly Ser Ala Leu Leu Lys Lys Gly Lys 
                245                 250                 255     


Phe Gly Lys Arg Glu Ser Arg Lys Thr Lys Leu Gly Ile Asp His Tyr 
            260                 265                 270         


Val Ala Ser Val Asn Val Val Arg Ala Met Ile Asp Asn Trp Asp Val 
        275                 280                 285             


Leu Phe Gln Val Pro Pro His Ile Gln Arg Gln Val Ala Lys Arg Val 
    290                 295                 300                 


Trp Lys Ser Ser Pro Glu Ala Leu Asp Phe Ile Arg Arg Arg Asn Leu 
305                 310                 315                 320 


Arg Lys Ile Gln Ser Ala Arg Ile Lys Met Glu Glu Asp Ala Leu Leu 
                325                 330                 335     


Ser Asp Pro Val Glu Thr Ser Ala Glu Ala Arg Ala Ala Val Leu Ala 
            340                 345                 350         


Gln Ser Lys Pro Ser Asp Glu Gly Ser Ser Glu Glu Pro Ala Val Pro 
        355                 360                 365             


Ser Gly Thr Ala Arg Ser His Asp Asp Glu Glu Gly Ala Gly Asn Pro 
    370                 375                 380                 


Pro Ile Pro Glu Gln Asp Arg Pro Leu Leu Arg Val Pro Arg Glu Lys 
385                 390                 395                 400 


Glu Ala Lys Thr Gly Val Ser Tyr Phe Phe Pro 
                405                 410     


<210>  1031
<211>  411
<212>  PRT
<213>  Homo Sapiens

<400>  1031

Met Gln Val Glu Glu Ala Thr Gly Gln Ala Ala Gly Arg Arg Arg Gly 
1               5                   10                  15      


Asn Val Val Arg Arg Val Phe Gly Arg Ile Arg Arg Phe Phe Ser Arg 
            20                  25                  30          


Arg Arg Asn Glu Pro Thr Leu Pro Arg Glu Phe Thr Arg Arg Gly Arg 
        35                  40                  45              


Arg Gly Ala Val Ser Val Asp Ser Leu Ala Glu Leu Glu Asp Gly Ala 
    50                  55                  60                  


Leu Leu Leu Gln Thr Leu Gln Leu Ser Lys Ile Ser Phe Pro Ile Gly 
65                  70                  75                  80  


Gln Arg Leu Leu Gly Ser Lys Arg Lys Met Ser Leu Asn Pro Ile Ala 
                85                  90                  95      


Lys Gln Ile Pro Gln Val Val Glu Ala Cys Cys Gln Phe Ile Glu Lys 
            100                 105                 110         


His Gly Leu Ser Ala Val Gly Ile Phe Thr Leu Glu Tyr Ser Val Gln 
        115                 120                 125             


Arg Val Arg Gln Leu Arg Glu Glu Phe Asp Gln Gly Leu Asp Val Val 
    130                 135                 140                 


Leu Asp Asp Asn Gln Asn Val His Asp Val Ala Ala Leu Leu Lys Glu 
145                 150                 155                 160 


Phe Phe Arg Asp Met Lys Asp Ser Leu Leu Pro Asp Asp Leu Tyr Met 
                165                 170                 175     


Ser Phe Leu Leu Thr Ala Thr Leu Lys Pro Gln Asp Gln Leu Ser Ala 
            180                 185                 190         


Leu Gln Leu Leu Val Tyr Leu Met Pro Pro Cys His Ser Asp Thr Leu 
        195                 200                 205             


Glu Arg Leu Leu Lys Ala Leu His Lys Ile Thr Glu Asn Cys Glu Asp 
    210                 215                 220                 


Ser Ile Gly Ile Asp Gly Gln Leu Val Pro Gly Asn Arg Met Thr Ser 
225                 230                 235                 240 


Thr Asn Leu Ala Leu Val Phe Gly Ser Ala Leu Leu Lys Lys Gly Lys 
                245                 250                 255     


Phe Gly Lys Arg Glu Ser Arg Lys Thr Lys Leu Gly Ile Asp His Tyr 
            260                 265                 270         


Val Ala Ser Val Asn Val Val Arg Ala Met Ile Asp Asn Trp Asp Val 
        275                 280                 285             


Leu Phe Gln Val Pro Pro His Ile Gln Arg Gln Val Ala Lys Arg Val 
    290                 295                 300                 


Trp Lys Ser Ser Pro Glu Ala Leu Asp Phe Ile Arg Arg Arg Asn Leu 
305                 310                 315                 320 


Arg Lys Ile Gln Ser Ala Arg Ile Lys Met Glu Glu Asp Ala Leu Leu 
                325                 330                 335     


Ser Asp Pro Val Glu Thr Ser Ala Glu Ala Arg Ala Ala Val Leu Ala 
            340                 345                 350         


Gln Ser Lys Pro Ser Asp Glu Gly Ser Ser Glu Glu Pro Ala Val Pro 
        355                 360                 365             


Ser Gly Thr Ala Arg Ser His Asp Asp Glu Glu Gly Ala Gly Asn Pro 
    370                 375                 380                 


Pro Ile Pro Glu Gln Asp Arg Pro Leu Leu Arg Val Pro Arg Glu Lys 
385                 390                 395                 400 


Glu Ala Lys Thr Gly Val Ser Tyr Phe Phe Pro 
                405                 410     


<210>  1032
<211>  516
<212>  PRT
<213>  Homo Sapiens

<400>  1032

Met Ser Val Leu Gly Gly Ala Pro Gly His Asn Pro Asp Arg Arg Thr 
1               5                   10                  15      


Lys Met Val Ser Ile His Ser Leu Ser Glu Leu Glu Arg Leu Lys Leu 
            20                  25                  30          


Gln Glu Thr Ala Tyr His Glu Leu Val Ala Arg His Phe Leu Ser Glu 
        35                  40                  45              


Phe Lys Pro Asp Arg Ala Leu Pro Ile Asp Arg Pro Asn Thr Leu Asp 
    50                  55                  60                  


Lys Trp Phe Leu Ile Leu Arg Gly Gln Gln Arg Ala Val Ser His Lys 
65                  70                  75                  80  


Thr Phe Gly Ile Ser Leu Glu Glu Val Leu Val Asn Glu Phe Thr Arg 
                85                  90                  95      


Arg Lys His Leu Glu Leu Thr Ala Thr Met Gln Val Glu Glu Ala Thr 
            100                 105                 110         


Gly Gln Ala Ala Gly Arg Arg Arg Gly Asn Val Val Arg Arg Val Phe 
        115                 120                 125             


Gly Arg Ile Arg Arg Phe Phe Ser Arg Arg Arg Asn Glu Pro Thr Leu 
    130                 135                 140                 


Pro Arg Glu Phe Thr Arg Arg Gly Arg Arg Gly Ala Val Ser Val Asp 
145                 150                 155                 160 


Ser Leu Ala Glu Leu Glu Asp Gly Ala Leu Leu Leu Gln Thr Leu Gln 
                165                 170                 175     


Leu Ser Lys Ile Ser Phe Pro Ile Gly Gln Arg Leu Leu Gly Ser Lys 
            180                 185                 190         


Arg Lys Met Ser Leu Asn Pro Ile Ala Lys Gln Ile Pro Gln Val Val 
        195                 200                 205             


Glu Ala Cys Cys Gln Phe Ile Glu Lys His Gly Leu Ser Ala Val Gly 
    210                 215                 220                 


Ile Phe Thr Leu Glu Tyr Ser Val Gln Arg Val Arg Gln Leu Arg Glu 
225                 230                 235                 240 


Glu Phe Asp Gln Gly Leu Asp Val Val Leu Asp Asp Asn Gln Asn Val 
                245                 250                 255     


His Asp Val Ala Ala Leu Leu Lys Glu Phe Phe Arg Asp Met Lys Asp 
            260                 265                 270         


Ser Leu Leu Pro Asp Asp Leu Tyr Met Ser Phe Leu Leu Thr Ala Thr 
        275                 280                 285             


Leu Lys Pro Gln Asp Gln Leu Ser Ala Leu Gln Leu Leu Val Tyr Leu 
    290                 295                 300                 


Met Pro Pro Cys His Ser Asp Thr Leu Glu Arg Leu Leu Lys Ala Leu 
305                 310                 315                 320 


His Lys Ile Thr Glu Asn Cys Glu Asp Ser Ile Gly Ile Asp Gly Gln 
                325                 330                 335     


Leu Val Pro Gly Asn Arg Met Thr Ser Thr Asn Leu Ala Leu Val Phe 
            340                 345                 350         


Gly Ser Ala Leu Leu Lys Lys Gly Lys Phe Gly Lys Arg Glu Ser Arg 
        355                 360                 365             


Lys Thr Lys Leu Gly Ile Asp His Tyr Val Ala Ser Val Asn Val Val 
    370                 375                 380                 


Arg Ala Met Ile Asp Asn Trp Asp Val Leu Phe Gln Val Pro Pro His 
385                 390                 395                 400 


Ile Gln Arg Gln Val Ala Lys Arg Val Trp Lys Ser Ser Pro Glu Ala 
                405                 410                 415     


Leu Asp Phe Ile Arg Arg Arg Asn Leu Arg Lys Ile Gln Ser Ala Arg 
            420                 425                 430         


Ile Lys Met Glu Glu Asp Ala Leu Leu Ser Asp Pro Val Glu Thr Ser 
        435                 440                 445             


Ala Glu Ala Arg Ala Ala Val Leu Ala Gln Ser Lys Pro Ser Asp Glu 
    450                 455                 460                 


Gly Ser Ser Glu Glu Pro Ala Val Pro Ser Gly Thr Ala Arg Ser His 
465                 470                 475                 480 


Asp Asp Glu Glu Gly Ala Gly Asn Pro Pro Ile Pro Glu Gln Asp Arg 
                485                 490                 495     


Pro Leu Leu Arg Val Pro Arg Glu Lys Glu Ala Lys Thr Gly Val Ser 
            500                 505                 510         


Tyr Phe Phe Pro 
        515     


<210>  1033
<211>  218
<212>  PRT
<213>  Homo Sapiens

<400>  1033

Met Val Ser Ile His Ser Leu Ser Glu Leu Glu Arg Leu Lys Leu Gln 
1               5                   10                  15      


Glu Thr Ala Tyr His Glu Leu Val Ala Arg His Phe Leu Ser Glu Phe 
            20                  25                  30          


Lys Pro Asp Arg Ala Leu Pro Ile Asp Arg Pro Asn Thr Leu Asp Lys 
        35                  40                  45              


Trp Phe Leu Ile Leu Arg Gly Gln Gln Arg Ala Val Ser His Lys Thr 
    50                  55                  60                  


Phe Gly Ile Ser Leu Glu Glu Val Leu Val Asn Glu Phe Thr Arg Arg 
65                  70                  75                  80  


Lys His Leu Glu Leu Thr Ala Thr Met Gln Val Glu Glu Ala Thr Gly 
                85                  90                  95      


Gln Ala Ala Gly Arg Arg Arg Gly Asn Val Val Arg Arg Val Phe Gly 
            100                 105                 110         


Arg Ile Arg Arg Phe Phe Ser Arg Arg Arg Asn Glu Pro Thr Leu Pro 
        115                 120                 125             


Arg Glu Phe Thr Arg Arg Gly Arg Arg Gly Ala Val Ser Val Asp Ser 
    130                 135                 140                 


Leu Ala Glu Leu Glu Asp Gly Ala Leu Leu Leu Gln Thr Leu Gln Leu 
145                 150                 155                 160 


Ser Lys Ile Ser Phe Pro Ile Gly Gln Arg Leu Leu Gly Ser Lys Arg 
                165                 170                 175     


Lys Met Ser Leu Asn Pro Ile Ala Lys Gln Ile Pro Gln Val Val Glu 
            180                 185                 190         


Ala Cys Cys Gln Phe Ile Glu Lys His Gly Leu Ser Ala Val Gly Ile 
        195                 200                 205             


Phe Thr Leu Glu Tyr Ser Val Gln Arg Val 
    210                 215             


<210>  1034
<211>  78
<212>  PRT
<213>  Homo Sapiens

<400>  1034

Gly Arg Gln Asp Gly Ser Glu Ser Glu Ala Val Ala Val Ala Leu Ala 
1               5                   10                  15      


Gly Arg Leu Arg Glu Leu Leu Arg Asp Leu Pro Pro Glu Asn Arg Ala 
            20                  25                  30          


Ser Leu Gln Tyr Leu Leu Arg His Leu Arg Arg Pro Ala Ser Ser Arg 
        35                  40                  45              


Leu Ser Ser Ser Thr Thr Ala Trp Ser Ser Arg Arg Ser Arg Arg Arg 
    50                  55                  60                  


Pro Pro Gly Ala Arg Thr Ser His Pro Thr Ser Glu Leu Arg 
65                  70                  75              


<210>  1035
<211>  1019
<212>  PRT
<213>  Homo Sapiens

<400>  1035

Met Cys Ile Cys Gly Thr Ala His Pro Val Leu Asp Glu Gly Pro Val 
1               5                   10                  15      


Arg Cys Arg Ala Gly Pro Arg Asp Leu Leu Glu Ala Arg Arg Pro Arg 
            20                  25                  30          


Ala His Glu Cys Leu Gly Glu Ala Leu Arg Val Met His Gln Ile Ile 
        35                  40                  45              


Ser Lys Tyr Pro Leu Leu Asn Thr Val Glu Thr Leu Thr Ala Ala Gly 
    50                  55                  60                  


Thr Leu Ile Ala Lys Val Lys Ala Phe His Tyr Glu Ser Asn Asn Asp 
65                  70                  75                  80  


Leu Glu Lys Gln Glu Phe Glu Lys Ala Leu Glu Thr Ile Ala Val Ala 
                85                  90                  95      


Phe Ser Ser Thr Val Ser Glu Phe Leu Met Gly Glu Val Asp Ser Ser 
            100                 105                 110         


Thr Leu Leu Ala Val Pro Pro Gly Asp Ser Ser Gln Ser Met Glu Ser 
        115                 120                 125             


Leu Tyr Gly Pro Gly Ser Glu Gly Thr Pro Pro Ser Leu Glu Asp Cys 
    130                 135                 140                 


Asp Ala Gly Cys Leu Pro Ala Glu Glu Val Asp Val Leu Leu Gln Arg 
145                 150                 155                 160 


Cys Glu Gly Gly Val Asp Ala Ala Leu Leu Tyr Ala Lys Asn Met Ala 
                165                 170                 175     


Lys Tyr Met Lys Asp Leu Ile Ser Tyr Leu Glu Lys Arg Thr Thr Leu 
            180                 185                 190         


Glu Met Glu Phe Ala Lys Gly Leu Gln Lys Ile Ala His Asn Cys Arg 
        195                 200                 205             


Gln Ser Val Met Gln Glu Pro His Met Pro Leu Leu Ser Ile Tyr Ser 
    210                 215                 220                 


Leu Ala Leu Glu Gln Asp Leu Glu Phe Gly His Ser Met Val Gln Ala 
225                 230                 235                 240 


Val Gly Thr Leu Gln Thr Gln Thr Phe Met Gln Pro Leu Thr Leu Arg 
                245                 250                 255     


Arg Leu Glu His Glu Lys Arg Arg Lys Glu Ile Lys Glu Ala Trp His 
            260                 265                 270         


Arg Ala Gln Arg Lys Leu Gln Glu Ala Glu Ser Asn Leu Arg Lys Ala 
        275                 280                 285             


Lys Gln Gly Tyr Val Gln Arg Cys Glu Asp His Asp Lys Ala Arg Phe 
    290                 295                 300                 


Leu Val Ala Lys Ala Glu Glu Glu Gln Ala Gly Ser Ala Pro Gly Ala 
305                 310                 315                 320 


Gly Ser Thr Ala Thr Lys Thr Leu Asp Lys Arg Arg Arg Leu Glu Glu 
                325                 330                 335     


Glu Ala Lys Asn Lys Ala Glu Glu Ala Met Ala Thr Tyr Arg Thr Cys 
            340                 345                 350         


Val Ala Asp Ala Lys Thr Gln Lys Gln Glu Leu Glu Asp Thr Lys Val 
        355                 360                 365             


Thr Ala Leu Arg Gln Ile Gln Glu Val Ile Arg Gln Ser Asp Gln Thr 
    370                 375                 380                 


Ile Lys Ser Ala Thr Ile Ser Tyr Tyr Gln Met Met His Met Gln Thr 
385                 390                 395                 400 


Ala Pro Leu Pro Val His Phe Gln Met Leu Cys Glu Ser Ser Lys Leu 
                405                 410                 415     


Tyr Asp Pro Gly Gln Gln Tyr Ala Ser His Val Arg Gln Leu Gln Arg 
            420                 425                 430         


Asp Gln Glu Pro Asp Val His Tyr Asp Phe Glu Pro His Val Ser Ala 
        435                 440                 445             


Asn Ala Trp Ser Pro Val Met Arg Ala Arg Lys Ser Ser Phe Asn Val 
    450                 455                 460                 


Ser Asp Val Ala Arg Pro Glu Ala Ala Gly Ser Pro Pro Glu Glu Gly 
465                 470                 475                 480 


Gly Cys Thr Glu Gly Thr Pro Ala Lys Asp His Arg Ala Gly Arg Gly 
                485                 490                 495     


His Gln Val His Lys Ser Trp Pro Leu Ser Ile Ser Asp Ser Asp Ser 
            500                 505                 510         


Gly Leu Asp Pro Gly Pro Gly Ala Gly Asp Phe Lys Lys Phe Glu Arg 
        515                 520                 525             


Thr Ser Ser Ser Gly Thr Met Ser Ser Thr Glu Glu Leu Val Asp Pro 
    530                 535                 540                 


Asp Gly Gly Ala Gly Ala Ser Ala Phe Glu Gln Ala Asp Leu Asn Gly 
545                 550                 555                 560 


Met Thr Pro Glu Leu Pro Val Ala Val Pro Ser Gly Pro Phe Arg His 
                565                 570                 575     


Glu Gly Leu Ser Lys Ala Ala Arg Thr His Arg Leu Arg Lys Leu Arg 
            580                 585                 590         


Thr Pro Ala Lys Cys Arg Glu Cys Asn Ser Tyr Val Tyr Phe Gln Gly 
        595                 600                 605             


Ala Glu Cys Glu Glu Cys Cys Leu Ala Cys His Lys Lys Cys Leu Glu 
    610                 615                 620                 


Thr Leu Ala Ile Gln Cys Gly His Lys Lys Leu Gln Gly Arg Leu Gln 
625                 630                 635                 640 


Leu Phe Gly Gln Asp Phe Ser His Ala Ala Arg Ser Ala Pro Asp Gly 
                645                 650                 655     


Val Pro Phe Ile Val Lys Lys Cys Val Cys Glu Ile Glu Arg Arg Ala 
            660                 665                 670         


Leu Arg Thr Lys Gly Ile Tyr Arg Val Asn Gly Val Lys Thr Arg Val 
        675                 680                 685             


Glu Lys Leu Cys Gln Ala Phe Glu Asn Gly Lys Glu Leu Val Glu Leu 
    690                 695                 700                 


Ser Gln Ala Ser Pro His Asp Ile Ser Asn Val Leu Lys Leu Tyr Leu 
705                 710                 715                 720 


Arg Gln Leu Pro Glu Pro Leu Ile Ser Phe Arg Leu Tyr His Glu Leu 
                725                 730                 735     


Val Gly Leu Ala Lys Asp Ser Leu Lys Ala Glu Ala Glu Ala Lys Ala 
            740                 745                 750         


Ala Ser Arg Gly Arg Gln Asp Gly Ser Glu Ser Glu Ala Val Ala Val 
        755                 760                 765             


Ala Leu Ala Gly Arg Leu Arg Glu Leu Leu Arg Asp Leu Pro Pro Glu 
    770                 775                 780                 


Asn Arg Ala Ser Leu Gln Tyr Leu Leu Arg His Leu Arg Arg Ile Val 
785                 790                 795                 800 


Glu Val Glu Gln Asp Asn Lys Met Thr Pro Gly Asn Leu Gly Ile Val 
                805                 810                 815     


Phe Gly Pro Thr Leu Leu Arg Pro Arg Pro Thr Glu Ala Thr Val Ser 
            820                 825                 830         


Leu Ser Ser Leu Val Asp Tyr Pro His Gln Ala Arg Val Ile Glu Thr 
        835                 840                 845             


Leu Ile Val His Tyr Gly Leu Val Phe Glu Glu Glu Pro Glu Glu Thr 
    850                 855                 860                 


Pro Gly Gly Gln Asp Glu Ser Ser Asn Gln Arg Ala Glu Val Val Val 
865                 870                 875                 880 


Gln Val Pro Tyr Leu Glu Ala Gly Glu Ala Val Val Tyr Pro Leu Gln 
                885                 890                 895     


Glu Ala Ala Ala Asp Gly Cys Arg Glu Ser Arg Val Val Ser Asn Asp 
            900                 905                 910         


Ser Asp Ser Asp Leu Glu Glu Ala Ser Glu Leu Leu Ser Ser Ser Glu 
        915                 920                 925             


Ala Ser Ala Leu Gly His Leu Ser Phe Leu Glu Gln Gln Gln Ser Glu 
    930                 935                 940                 


Ala Ser Leu Glu Val Ala Ser Gly Ser His Ser Gly Ser Glu Glu Gln 
945                 950                 955                 960 


Leu Glu Ala Thr Ala Arg Glu Asp Gly Asp Gly Asp Glu Asp Gly Pro 
                965                 970                 975     


Ala Gln Gln Leu Ser Gly Phe Asn Thr Asn Gln Ser Asn Asn Val Leu 
            980                 985                 990         


Gln Ala Pro Leu Pro Pro Met Arg  Leu Arg Gly Gly Arg  Met Thr Leu 
        995                 1000                 1005             


Gly Ser  Cys Arg Glu Arg Gln  Pro Glu Phe Val 
    1010                 1015                 


<210>  1036
<211>  1136
<212>  PRT
<213>  Homo Sapiens

<400>  1036

Met Phe Ser Arg Lys Lys Arg Glu Leu Met Lys Thr Pro Ser Ile Ser 
1               5                   10                  15      


Lys Lys Asn Arg Ala Gly Ser Pro Ser Pro Gln Pro Ser Gly Glu Leu 
            20                  25                  30          


Pro Arg Lys Asp Gly Ala Asp Ala Val Phe Pro Gly Pro Ser Leu Glu 
        35                  40                  45              


Pro Pro Ala Gly Ser Ser Gly Val Lys Ala Thr Gly Thr Leu Lys Arg 
    50                  55                  60                  


Pro Thr Ser Leu Ser Arg His Ala Ser Ala Ala Gly Phe Pro Leu Ser 
65                  70                  75                  80  


Gly Ala Ala Ser Trp Thr Leu Gly Arg Ser His Arg Ser Pro Leu Thr 
                85                  90                  95      


Ala Ala Ser Pro Gly Glu Leu Pro Thr Glu Gly Ala Gly Pro Asp Val 
            100                 105                 110         


Val Glu Asp Ile Ser His Leu Leu Ala Asp Val Ala Arg Phe Ala Glu 
        115                 120                 125             


Gly Leu Glu Lys Leu Lys Glu Cys Val Leu Arg Asp Asp Leu Leu Glu 
    130                 135                 140                 


Ala Arg Arg Pro Arg Ala His Glu Cys Leu Gly Glu Ala Leu Arg Val 
145                 150                 155                 160 


Met His Gln Ile Ile Ser Lys Tyr Pro Leu Leu Asn Thr Val Glu Thr 
                165                 170                 175     


Leu Thr Ala Ala Gly Thr Leu Ile Ala Lys Val Lys Ala Phe His Tyr 
            180                 185                 190         


Glu Ser Asn Asn Asp Leu Glu Lys Gln Glu Phe Glu Lys Ala Leu Glu 
        195                 200                 205             


Thr Ile Ala Val Ala Phe Ser Ser Thr Val Ser Glu Phe Leu Met Gly 
    210                 215                 220                 


Glu Val Asp Ser Ser Thr Leu Leu Ala Val Pro Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Gln Ser Met Glu Ser Leu Tyr Gly Pro Gly Ser Glu Gly Thr Pro Pro 
                245                 250                 255     


Ser Leu Glu Asp Cys Asp Ala Gly Cys Leu Pro Ala Glu Glu Val Asp 
            260                 265                 270         


Val Leu Leu Gln Arg Cys Glu Gly Gly Val Asp Ala Ala Leu Leu Tyr 
        275                 280                 285             


Ala Lys Asn Met Ala Lys Tyr Met Lys Asp Leu Ile Ser Tyr Leu Glu 
    290                 295                 300                 


Lys Arg Thr Thr Leu Glu Met Glu Phe Ala Lys Gly Leu Gln Lys Ile 
305                 310                 315                 320 


Ala His Asn Cys Arg Gln Ser Val Met Gln Glu Pro His Met Pro Leu 
                325                 330                 335     


Leu Ser Ile Tyr Ser Leu Ala Leu Glu Gln Asp Leu Glu Phe Gly His 
            340                 345                 350         


Ser Met Val Gln Ala Val Gly Thr Leu Gln Thr Gln Thr Phe Met Gln 
        355                 360                 365             


Pro Leu Thr Leu Arg Arg Leu Glu His Glu Lys Arg Arg Lys Glu Ile 
    370                 375                 380                 


Lys Glu Ala Trp His Arg Ala Gln Arg Lys Leu Gln Glu Ala Glu Ser 
385                 390                 395                 400 


Asn Leu Arg Lys Ala Lys Gln Gly Tyr Val Gln Arg Cys Glu Asp His 
                405                 410                 415     


Asp Lys Ala Arg Phe Leu Val Ala Lys Ala Glu Glu Glu Gln Ala Gly 
            420                 425                 430         


Ser Ala Pro Gly Ala Gly Ser Thr Ala Thr Lys Thr Leu Asp Lys Arg 
        435                 440                 445             


Arg Arg Leu Glu Glu Glu Ala Lys Asn Lys Ala Glu Glu Ala Met Ala 
    450                 455                 460                 


Thr Tyr Arg Thr Cys Val Ala Asp Ala Lys Thr Gln Lys Gln Glu Leu 
465                 470                 475                 480 


Glu Asp Thr Lys Val Thr Ala Leu Arg Gln Ile Gln Glu Val Ile Arg 
                485                 490                 495     


Gln Ser Asp Gln Thr Ile Lys Ser Ala Thr Ile Ser Tyr Tyr Gln Met 
            500                 505                 510         


Met His Met Gln Thr Ala Pro Leu Pro Val His Phe Gln Met Leu Cys 
        515                 520                 525             


Glu Ser Ser Lys Leu Tyr Asp Pro Gly Gln Gln Tyr Ala Ser His Val 
    530                 535                 540                 


Arg Gln Leu Gln Arg Asp Gln Glu Pro Asp Val His Tyr Asp Phe Glu 
545                 550                 555                 560 


Pro His Val Ser Ala Asn Ala Trp Ser Pro Val Met Arg Ala Arg Lys 
                565                 570                 575     


Ser Ser Phe Asn Val Ser Asp Val Ala Arg Pro Glu Ala Ala Gly Ser 
            580                 585                 590         


Pro Pro Glu Glu Gly Gly Cys Thr Glu Gly Thr Pro Ala Lys Asp His 
        595                 600                 605             


Arg Ala Gly Arg Gly His Gln Val His Lys Ser Trp Pro Leu Ser Ile 
    610                 615                 620                 


Ser Asp Ser Asp Ser Gly Leu Asp Pro Gly Pro Gly Ala Gly Asp Phe 
625                 630                 635                 640 


Lys Lys Phe Glu Arg Thr Ser Ser Ser Gly Thr Met Ser Ser Thr Glu 
                645                 650                 655     


Glu Leu Val Asp Pro Asp Gly Gly Ala Gly Ala Ser Ala Phe Glu Gln 
            660                 665                 670         


Ala Asp Leu Asn Gly Met Thr Pro Glu Leu Pro Val Ala Val Pro Ser 
        675                 680                 685             


Gly Pro Phe Arg His Glu Gly Leu Ser Lys Ala Ala Arg Thr His Arg 
    690                 695                 700                 


Leu Arg Lys Leu Arg Thr Pro Ala Lys Cys Arg Glu Cys Asn Ser Tyr 
705                 710                 715                 720 


Val Tyr Phe Gln Gly Ala Glu Cys Glu Glu Cys Cys Leu Ala Cys His 
                725                 730                 735     


Lys Lys Cys Leu Glu Thr Leu Ala Ile Gln Cys Gly His Lys Lys Leu 
            740                 745                 750         


Gln Gly Arg Leu Gln Leu Phe Gly Gln Asp Phe Ser His Ala Ala Arg 
        755                 760                 765             


Ser Ala Pro Asp Gly Val Pro Phe Ile Val Lys Lys Cys Val Cys Glu 
    770                 775                 780                 


Ile Glu Arg Arg Ala Leu Arg Thr Lys Gly Ile Tyr Arg Val Asn Gly 
785                 790                 795                 800 


Val Lys Thr Arg Val Glu Lys Leu Cys Gln Ala Phe Glu Asn Gly Lys 
                805                 810                 815     


Glu Leu Val Glu Leu Ser Gln Ala Ser Pro His Asp Ile Ser Asn Val 
            820                 825                 830         


Leu Lys Leu Tyr Leu Arg Gln Leu Pro Glu Pro Leu Ile Ser Phe Arg 
        835                 840                 845             


Leu Tyr His Glu Leu Val Gly Leu Ala Lys Asp Ser Leu Lys Ala Glu 
    850                 855                 860                 


Ala Glu Ala Lys Ala Ala Ser Arg Gly Arg Gln Asp Gly Ser Glu Ser 
865                 870                 875                 880 


Glu Ala Val Ala Val Ala Leu Ala Gly Arg Leu Arg Glu Leu Leu Arg 
                885                 890                 895     


Asp Leu Pro Pro Glu Asn Arg Ala Ser Leu Gln Tyr Leu Leu Arg His 
            900                 905                 910         


Leu Arg Arg Ile Val Glu Val Glu Gln Asp Asn Lys Met Thr Pro Gly 
        915                 920                 925             


Asn Leu Gly Ile Val Phe Gly Pro Thr Leu Leu Arg Pro Arg Pro Thr 
    930                 935                 940                 


Glu Ala Thr Val Ser Leu Ser Ser Leu Val Asp Tyr Pro His Gln Ala 
945                 950                 955                 960 


Arg Val Ile Glu Thr Leu Ile Val His Tyr Gly Leu Val Phe Glu Glu 
                965                 970                 975     


Glu Pro Glu Glu Thr Pro Gly Gly Gln Asp Glu Ser Ser Asn Gln Arg 
            980                 985                 990         


Ala Glu Val Val Val Gln Val Pro  Tyr Leu Glu Ala Gly  Glu Ala Val 
        995                 1000                 1005             


Val Tyr  Pro Leu Gln Glu Ala  Ala Ala Asp Gly Cys  Arg Glu Ser 
    1010                 1015                 1020             


Arg Val  Val Ser Asn Asp Ser  Asp Ser Asp Leu Glu  Glu Ala Ser 
    1025                 1030                 1035             


Glu Leu  Leu Ser Ser Ser Glu  Ala Ser Ala Leu Gly  His Leu Ser 
    1040                 1045                 1050             


Phe Leu  Glu Gln Gln Gln Ser  Glu Ala Ser Leu Glu  Val Ala Ser 
    1055                 1060                 1065             


Gly Ser  His Ser Gly Ser Glu  Glu Gln Leu Glu Ala  Thr Ala Arg 
    1070                 1075                 1080             


Glu Asp  Gly Asp Gly Asp Glu  Asp Gly Pro Ala Gln  Gln Leu Ser 
    1085                 1090                 1095             


Gly Phe  Asn Thr Asn Gln Ser  Asn Asn Val Leu Gln  Ala Pro Leu 
    1100                 1105                 1110             


Pro Pro  Met Arg Leu Arg Gly  Gly Arg Met Thr Leu  Gly Ser Cys 
    1115                 1120                 1125             


Arg Glu  Arg Gln Pro Glu Phe  Val 
    1130                 1135     


<210>  1037
<211>  1163
<212>  PRT
<213>  Homo Sapiens

<400>  1037

Met Phe Ser Arg Lys Lys Arg Glu Leu Met Lys Thr Pro Ser Ile Ser 
1               5                   10                  15      


Lys Lys Asn Arg Ala Gly Ser Pro Ser Pro Gln Pro Ser Gly Pro His 
            20                  25                  30          


Phe Ile Ser Gly Glu Thr Glu Ala Val Ser Arg Pro Glu Asn Pro Phe 
        35                  40                  45              


Asn Glu Leu Pro Ser Asp Leu Pro Lys Glu Leu Pro Arg Lys Asp Gly 
    50                  55                  60                  


Ala Asp Ala Val Phe Pro Gly Pro Ser Leu Glu Pro Pro Ala Gly Ser 
65                  70                  75                  80  


Ser Gly Val Lys Ala Thr Gly Thr Leu Lys Arg Pro Thr Ser Leu Ser 
                85                  90                  95      


Arg His Ala Ser Ala Ala Gly Phe Pro Leu Ser Gly Ala Ala Ser Trp 
            100                 105                 110         


Thr Leu Gly Arg Ser His Arg Ser Pro Leu Thr Ala Ala Ser Pro Gly 
        115                 120                 125             


Glu Leu Pro Thr Glu Gly Ala Gly Pro Asp Val Val Glu Asp Ile Ser 
    130                 135                 140                 


His Leu Leu Ala Asp Val Ala Arg Phe Ala Glu Gly Leu Glu Lys Leu 
145                 150                 155                 160 


Lys Glu Cys Val Leu Arg Asp Asp Leu Leu Glu Ala Arg Arg Pro Arg 
                165                 170                 175     


Ala His Glu Cys Leu Gly Glu Ala Leu Arg Val Met His Gln Ile Ile 
            180                 185                 190         


Ser Lys Tyr Pro Leu Leu Asn Thr Val Glu Thr Leu Thr Ala Ala Gly 
        195                 200                 205             


Thr Leu Ile Ala Lys Val Lys Ala Phe His Tyr Glu Ser Asn Asn Asp 
    210                 215                 220                 


Leu Glu Lys Gln Glu Phe Glu Lys Ala Leu Glu Thr Ile Ala Val Ala 
225                 230                 235                 240 


Phe Ser Ser Thr Val Ser Glu Phe Leu Met Gly Glu Val Asp Ser Ser 
                245                 250                 255     


Thr Leu Leu Ala Val Pro Pro Gly Asp Ser Ser Gln Ser Met Glu Ser 
            260                 265                 270         


Leu Tyr Gly Pro Gly Ser Glu Gly Thr Pro Pro Ser Leu Glu Asp Cys 
        275                 280                 285             


Asp Ala Gly Cys Leu Pro Ala Glu Glu Val Asp Val Leu Leu Gln Arg 
    290                 295                 300                 


Cys Glu Gly Gly Val Asp Ala Ala Leu Leu Tyr Ala Lys Asn Met Ala 
305                 310                 315                 320 


Lys Tyr Met Lys Asp Leu Ile Ser Tyr Leu Glu Lys Arg Thr Thr Leu 
                325                 330                 335     


Glu Met Glu Phe Ala Lys Gly Leu Gln Lys Ile Ala His Asn Cys Arg 
            340                 345                 350         


Gln Ser Val Met Gln Glu Pro His Met Pro Leu Leu Ser Ile Tyr Ser 
        355                 360                 365             


Leu Ala Leu Glu Gln Asp Leu Glu Phe Gly His Ser Met Val Gln Ala 
    370                 375                 380                 


Val Gly Thr Leu Gln Thr Gln Thr Phe Met Gln Pro Leu Thr Leu Arg 
385                 390                 395                 400 


Arg Leu Glu His Glu Lys Arg Arg Lys Glu Ile Lys Glu Ala Trp His 
                405                 410                 415     


Arg Ala Gln Arg Lys Leu Gln Glu Ala Glu Ser Asn Leu Arg Lys Ala 
            420                 425                 430         


Lys Gln Gly Tyr Val Gln Arg Cys Glu Asp His Asp Lys Ala Arg Phe 
        435                 440                 445             


Leu Val Ala Lys Ala Glu Glu Glu Gln Ala Gly Ser Ala Pro Gly Ala 
    450                 455                 460                 


Gly Ser Thr Ala Thr Lys Thr Leu Asp Lys Arg Arg Arg Leu Glu Glu 
465                 470                 475                 480 


Glu Ala Lys Asn Lys Ala Glu Glu Ala Met Ala Thr Tyr Arg Thr Cys 
                485                 490                 495     


Val Ala Asp Ala Lys Thr Gln Lys Gln Glu Leu Glu Asp Thr Lys Val 
            500                 505                 510         


Thr Ala Leu Arg Gln Ile Gln Glu Val Ile Arg Gln Ser Asp Gln Thr 
        515                 520                 525             


Ile Lys Ser Ala Thr Ile Ser Tyr Tyr Gln Met Met His Met Gln Thr 
    530                 535                 540                 


Ala Pro Leu Pro Val His Phe Gln Met Leu Cys Glu Ser Ser Lys Leu 
545                 550                 555                 560 


Tyr Asp Pro Gly Gln Gln Tyr Ala Ser His Val Arg Gln Leu Gln Arg 
                565                 570                 575     


Asp Gln Glu Pro Asp Val His Tyr Asp Phe Glu Pro His Val Ser Ala 
            580                 585                 590         


Asn Ala Trp Ser Pro Val Met Arg Ala Arg Lys Ser Ser Phe Asn Val 
        595                 600                 605             


Ser Asp Val Ala Arg Pro Glu Ala Ala Gly Ser Pro Pro Glu Glu Gly 
    610                 615                 620                 


Gly Cys Thr Glu Gly Thr Pro Ala Lys Asp His Arg Ala Gly Arg Gly 
625                 630                 635                 640 


His Gln Val His Lys Ser Trp Pro Leu Ser Ile Ser Asp Ser Asp Ser 
                645                 650                 655     


Gly Leu Asp Pro Gly Pro Gly Ala Gly Asp Phe Lys Lys Phe Glu Arg 
            660                 665                 670         


Thr Ser Ser Ser Gly Thr Met Ser Ser Thr Glu Glu Leu Val Asp Pro 
        675                 680                 685             


Asp Gly Gly Ala Gly Ala Ser Ala Phe Glu Gln Ala Asp Leu Asn Gly 
    690                 695                 700                 


Met Thr Pro Glu Leu Pro Val Ala Val Pro Ser Gly Pro Phe Arg His 
705                 710                 715                 720 


Glu Gly Leu Ser Lys Ala Ala Arg Thr His Arg Leu Arg Lys Leu Arg 
                725                 730                 735     


Thr Pro Ala Lys Cys Arg Glu Cys Asn Ser Tyr Val Tyr Phe Gln Gly 
            740                 745                 750         


Ala Glu Cys Glu Glu Cys Cys Leu Ala Cys His Lys Lys Cys Leu Glu 
        755                 760                 765             


Thr Leu Ala Ile Gln Cys Gly His Lys Lys Leu Gln Gly Arg Leu Gln 
    770                 775                 780                 


Leu Phe Gly Gln Asp Phe Ser His Ala Ala Arg Ser Ala Pro Asp Gly 
785                 790                 795                 800 


Val Pro Phe Ile Val Lys Lys Cys Val Cys Glu Ile Glu Arg Arg Ala 
                805                 810                 815     


Leu Arg Thr Lys Gly Ile Tyr Arg Val Asn Gly Val Lys Thr Arg Val 
            820                 825                 830         


Glu Lys Leu Cys Gln Ala Phe Glu Asn Gly Lys Glu Leu Val Glu Leu 
        835                 840                 845             


Ser Gln Ala Ser Pro His Asp Ile Ser Asn Val Leu Lys Leu Tyr Leu 
    850                 855                 860                 


Arg Gln Leu Pro Glu Pro Leu Ile Ser Phe Arg Leu Tyr His Glu Leu 
865                 870                 875                 880 


Val Gly Leu Ala Lys Asp Ser Leu Lys Ala Glu Ala Glu Ala Lys Ala 
                885                 890                 895     


Ala Ser Arg Gly Arg Gln Asp Gly Ser Glu Ser Glu Ala Val Ala Val 
            900                 905                 910         


Ala Leu Ala Gly Arg Leu Arg Glu Leu Leu Arg Asp Leu Pro Pro Glu 
        915                 920                 925             


Asn Arg Ala Ser Leu Gln Tyr Leu Leu Arg His Leu Arg Arg Ile Val 
    930                 935                 940                 


Glu Val Glu Gln Asp Asn Lys Met Thr Pro Gly Asn Leu Gly Ile Val 
945                 950                 955                 960 


Phe Gly Pro Thr Leu Leu Arg Pro Arg Pro Thr Glu Ala Thr Val Ser 
                965                 970                 975     


Leu Ser Ser Leu Val Asp Tyr Pro His Gln Ala Arg Val Ile Glu Thr 
            980                 985                 990         


Leu Ile Val His Tyr Gly Leu Val  Phe Glu Glu Glu Pro  Glu Glu Thr 
        995                 1000                 1005             


Pro Gly  Gly Gln Asp Glu Ser  Ser Asn Gln Arg Ala  Glu Val Val 
    1010                 1015                 1020             


Val Gln  Val Pro Tyr Leu Glu  Ala Gly Glu Ala Val  Val Tyr Pro 
    1025                 1030                 1035             


Leu Gln  Glu Ala Ala Ala Asp  Gly Cys Arg Glu Ser  Arg Val Val 
    1040                 1045                 1050             


Ser Asn  Asp Ser Asp Ser Asp  Leu Glu Glu Ala Ser  Glu Leu Leu 
    1055                 1060                 1065             


Ser Ser  Ser Glu Ala Ser Ala  Leu Gly His Leu Ser  Phe Leu Glu 
    1070                 1075                 1080             


Gln Gln  Gln Ser Glu Ala Ser  Leu Glu Val Ala Ser  Gly Ser His 
    1085                 1090                 1095             


Ser Gly  Ser Glu Glu Gln Leu  Glu Ala Thr Ala Arg  Glu Asp Gly 
    1100                 1105                 1110             


Asp Gly  Asp Glu Asp Gly Pro  Ala Gln Gln Leu Ser  Gly Phe Asn 
    1115                 1120                 1125             


Thr Asn  Gln Ser Asn Asn Val  Leu Gln Ala Pro Leu  Pro Pro Met 
    1130                 1135                 1140             


Arg Leu  Arg Gly Gly Arg Met  Thr Leu Gly Ser Cys  Arg Glu Arg 
    1145                 1150                 1155             


Gln Pro  Glu Phe Val 
    1160             


<210>  1038
<211>  60
<212>  PRT
<213>  Homo Sapiens

<400>  1038

Met Phe Ser Arg Lys Lys Arg Glu Leu Met Lys Thr Pro Ser Ile Ser 
1               5                   10                  15      


Lys Lys Asn Arg Ala Gly Ser Pro Ser Pro Gln Pro Ser Gly Thr Ser 
            20                  25                  30          


Leu Arg Pro Ala Ala Arg Gly Pro Thr Ser Ala Trp Val Arg Leu Cys 
        35                  40                  45              


Val Ser Cys Ile Arg Ser Ser Pro Ser Thr Arg Cys 
    50                  55                  60  


<210>  1039
<211>  771
<212>  PRT
<213>  Homo Sapiens

<400>  1039

Met Gly Val Gly Arg Lys Gly Gly Ala Gly Glu Thr Glu Ser His Pro 
1               5                   10                  15      


Arg Ile Gly Leu Glu Leu Ala Ser Trp Leu Pro His Pro Gln Gln Glu 
            20                  25                  30          


Ala Glu Ser Asn Leu Arg Lys Ala Lys Gln Gly Tyr Val Gln Arg Cys 
        35                  40                  45              


Glu Asp His Asp Lys Ala Arg Phe Leu Val Ala Lys Ala Glu Glu Glu 
    50                  55                  60                  


Gln Ala Gly Ser Ala Pro Gly Ala Gly Ser Thr Ala Thr Lys Thr Leu 
65                  70                  75                  80  


Asp Lys Arg Arg Arg Leu Glu Glu Glu Ala Lys Asn Lys Ala Glu Glu 
                85                  90                  95      


Ala Met Ala Thr Tyr Arg Thr Cys Val Ala Asp Ala Lys Thr Gln Lys 
            100                 105                 110         


Gln Glu Leu Glu Asp Thr Lys Val Thr Ala Leu Arg Gln Ile Gln Glu 
        115                 120                 125             


Val Ile Arg Gln Ser Asp Gln Thr Ile Lys Ser Ala Thr Ile Ser Tyr 
    130                 135                 140                 


Tyr Gln Met Met His Met Gln Thr Ala Pro Leu Pro Val His Phe Gln 
145                 150                 155                 160 


Met Leu Cys Glu Ser Ser Lys Leu Tyr Asp Pro Gly Gln Gln Tyr Ala 
                165                 170                 175     


Ser His Val Arg Gln Leu Gln Arg Asp Gln Glu Pro Asp Val His Tyr 
            180                 185                 190         


Asp Phe Glu Pro His Val Ser Ala Asn Ala Trp Ser Pro Val Met Arg 
        195                 200                 205             


Ala Arg Lys Ser Ser Phe Asn Val Ser Asp Val Ala Arg Pro Glu Ala 
    210                 215                 220                 


Ala Gly Ser Pro Pro Glu Glu Gly Gly Cys Thr Glu Gly Thr Pro Ala 
225                 230                 235                 240 


Lys Asp His Arg Ala Gly Arg Gly His Gln Val His Lys Ser Trp Pro 
                245                 250                 255     


Leu Ser Ile Ser Asp Ser Asp Ser Gly Leu Asp Pro Gly Pro Gly Ala 
            260                 265                 270         


Gly Asp Phe Lys Lys Phe Glu Arg Thr Ser Ser Ser Gly Thr Met Ser 
        275                 280                 285             


Ser Thr Glu Glu Leu Val Asp Pro Asp Gly Gly Ala Gly Ala Ser Ala 
    290                 295                 300                 


Phe Glu Gln Ala Asp Leu Asn Gly Met Thr Pro Glu Leu Pro Val Ala 
305                 310                 315                 320 


Val Pro Ser Gly Pro Phe Arg His Glu Gly Leu Ser Lys Ala Ala Arg 
                325                 330                 335     


Thr His Arg Leu Arg Lys Leu Arg Thr Pro Ala Lys Cys Arg Glu Cys 
            340                 345                 350         


Asn Ser Tyr Val Tyr Phe Gln Gly Ala Glu Cys Glu Glu Cys Cys Leu 
        355                 360                 365             


Ala Cys His Lys Lys Cys Leu Glu Thr Leu Ala Ile Gln Cys Gly His 
    370                 375                 380                 


Lys Lys Leu Gln Gly Arg Leu Gln Leu Phe Gly Gln Asp Phe Ser His 
385                 390                 395                 400 


Ala Ala Arg Ser Ala Pro Asp Gly Val Pro Phe Ile Val Lys Lys Cys 
                405                 410                 415     


Val Cys Glu Ile Glu Arg Arg Ala Leu Arg Thr Lys Gly Ile Tyr Arg 
            420                 425                 430         


Val Asn Gly Val Lys Thr Arg Val Glu Lys Leu Cys Gln Ala Phe Glu 
        435                 440                 445             


Asn Gly Lys Glu Leu Val Glu Leu Ser Gln Ala Ser Pro His Asp Ile 
    450                 455                 460                 


Ser Asn Val Leu Lys Leu Tyr Leu Arg Gln Leu Pro Glu Pro Leu Ile 
465                 470                 475                 480 


Ser Phe Arg Leu Tyr His Glu Leu Val Gly Leu Ala Lys Asp Ser Leu 
                485                 490                 495     


Lys Ala Glu Ala Glu Ala Lys Ala Ala Ser Arg Gly Arg Gln Asp Gly 
            500                 505                 510         


Ser Glu Ser Glu Ala Val Ala Val Ala Leu Ala Gly Arg Leu Arg Glu 
        515                 520                 525             


Leu Leu Arg Asp Leu Pro Pro Glu Asn Arg Ala Ser Leu Gln Tyr Leu 
    530                 535                 540                 


Leu Arg His Leu Arg Arg Ile Val Glu Val Glu Gln Asp Asn Lys Met 
545                 550                 555                 560 


Thr Pro Gly Asn Leu Gly Ile Val Phe Gly Pro Thr Leu Leu Arg Pro 
                565                 570                 575     


Arg Pro Thr Glu Ala Thr Val Ser Leu Ser Ser Leu Val Asp Tyr Pro 
            580                 585                 590         


His Gln Ala Arg Val Ile Glu Thr Leu Ile Val His Tyr Gly Leu Val 
        595                 600                 605             


Phe Glu Glu Glu Pro Glu Glu Thr Pro Gly Gly Gln Asp Glu Ser Ser 
    610                 615                 620                 


Asn Gln Arg Ala Glu Val Val Val Gln Val Pro Tyr Leu Glu Ala Gly 
625                 630                 635                 640 


Glu Ala Val Val Tyr Pro Leu Gln Glu Ala Ala Ala Asp Gly Cys Arg 
                645                 650                 655     


Glu Ser Arg Val Val Ser Asn Asp Ser Asp Ser Asp Leu Glu Glu Ala 
            660                 665                 670         


Ser Glu Leu Leu Ser Ser Ser Glu Ala Ser Ala Leu Gly His Leu Ser 
        675                 680                 685             


Phe Leu Glu Gln Gln Gln Ser Glu Ala Ser Leu Glu Val Ala Ser Gly 
    690                 695                 700                 


Ser His Ser Gly Ser Glu Glu Gln Leu Glu Ala Thr Ala Arg Glu Asp 
705                 710                 715                 720 


Gly Asp Gly Asp Glu Asp Gly Pro Ala Gln Gln Leu Ser Gly Phe Asn 
                725                 730                 735     


Thr Asn Gln Ser Asn Asn Val Leu Gln Ala Pro Leu Pro Pro Met Arg 
            740                 745                 750         


Leu Arg Gly Gly Arg Met Thr Leu Gly Ser Cys Arg Glu Arg Gln Pro 
        755                 760                 765             


Glu Phe Val 
    770     


<210>  1040
<211>  1140
<212>  PRT
<213>  Homo Sapiens

<400>  1040

Met Leu Gly Arg Arg Leu Gly Ala Arg Ala Ser Tyr Ser Pro Tyr Arg 
1               5                   10                  15      


Ala Gly Arg Gln Gly Pro Gln Gln Arg Gly Arg Asp Pro Gly Ile Gln 
            20                  25                  30          


Leu Thr Glu Leu Pro Arg Lys Asp Gly Ala Asp Ala Val Phe Pro Gly 
        35                  40                  45              


Pro Ser Leu Glu Pro Pro Ala Gly Ser Ser Gly Val Lys Ala Thr Gly 
    50                  55                  60                  


Thr Leu Lys Arg Pro Thr Ser Leu Ser Arg His Ala Ser Ala Ala Gly 
65                  70                  75                  80  


Phe Pro Leu Ser Gly Ala Ala Ser Trp Thr Leu Gly Arg Ser His Arg 
                85                  90                  95      


Ser Pro Leu Thr Ala Ala Ser Pro Gly Glu Leu Pro Thr Glu Gly Ala 
            100                 105                 110         


Gly Pro Asp Val Val Glu Asp Ile Ser His Leu Leu Ala Asp Val Ala 
        115                 120                 125             


Arg Phe Ala Glu Gly Leu Glu Lys Leu Lys Glu Cys Val Leu Arg Asp 
    130                 135                 140                 


Asp Leu Leu Glu Ala Arg Arg Pro Arg Ala His Glu Cys Leu Gly Glu 
145                 150                 155                 160 


Ala Leu Arg Val Met His Gln Ile Ile Ser Lys Tyr Pro Leu Leu Asn 
                165                 170                 175     


Thr Val Glu Thr Leu Thr Ala Ala Gly Thr Leu Ile Ala Lys Val Lys 
            180                 185                 190         


Ala Phe His Tyr Glu Ser Asn Asn Asp Leu Glu Lys Gln Glu Phe Glu 
        195                 200                 205             


Lys Ala Leu Glu Thr Ile Ala Val Ala Phe Ser Ser Thr Val Ser Glu 
    210                 215                 220                 


Phe Leu Met Gly Glu Val Asp Ser Ser Thr Leu Leu Ala Val Pro Pro 
225                 230                 235                 240 


Gly Asp Ser Ser Gln Ser Met Glu Ser Leu Tyr Gly Pro Gly Ser Glu 
                245                 250                 255     


Gly Thr Pro Pro Ser Leu Glu Asp Cys Asp Ala Gly Cys Leu Pro Ala 
            260                 265                 270         


Glu Glu Val Asp Val Leu Leu Gln Arg Cys Glu Gly Gly Val Asp Ala 
        275                 280                 285             


Ala Leu Leu Tyr Ala Lys Asn Met Ala Lys Tyr Met Lys Asp Leu Ile 
    290                 295                 300                 


Ser Tyr Leu Glu Lys Arg Thr Thr Leu Glu Met Glu Phe Ala Lys Gly 
305                 310                 315                 320 


Leu Gln Lys Ile Ala His Asn Cys Arg Gln Ser Val Met Gln Glu Pro 
                325                 330                 335     


His Met Pro Leu Leu Ser Ile Tyr Ser Leu Ala Leu Glu Gln Asp Leu 
            340                 345                 350         


Glu Phe Gly His Ser Met Val Gln Ala Val Gly Thr Leu Gln Thr Gln 
        355                 360                 365             


Thr Phe Met Gln Pro Leu Thr Leu Arg Arg Leu Glu His Glu Lys Arg 
    370                 375                 380                 


Arg Lys Glu Ile Lys Glu Ala Trp His Arg Ala Gln Arg Lys Leu Gln 
385                 390                 395                 400 


Glu Ala Glu Ser Asn Leu Arg Lys Ala Lys Gln Gly Tyr Val Gln Arg 
                405                 410                 415     


Cys Glu Asp His Asp Lys Ala Arg Phe Leu Val Ala Lys Ala Glu Glu 
            420                 425                 430         


Glu Gln Ala Gly Ser Ala Pro Gly Ala Gly Ser Thr Ala Thr Lys Thr 
        435                 440                 445             


Leu Asp Lys Arg Arg Arg Leu Glu Glu Glu Ala Lys Asn Lys Ala Glu 
    450                 455                 460                 


Glu Ala Met Ala Thr Tyr Arg Thr Cys Val Ala Asp Ala Lys Thr Gln 
465                 470                 475                 480 


Lys Gln Glu Leu Glu Asp Thr Lys Val Thr Ala Leu Arg Gln Ile Gln 
                485                 490                 495     


Glu Val Ile Arg Gln Ser Asp Gln Thr Ile Lys Ser Ala Thr Ile Ser 
            500                 505                 510         


Tyr Tyr Gln Met Met His Met Gln Thr Ala Pro Leu Pro Val His Phe 
        515                 520                 525             


Gln Met Leu Cys Glu Ser Ser Lys Leu Tyr Asp Pro Gly Gln Gln Tyr 
    530                 535                 540                 


Ala Ser His Val Arg Gln Leu Gln Arg Asp Gln Glu Pro Asp Val His 
545                 550                 555                 560 


Tyr Asp Phe Glu Pro His Val Ser Ala Asn Ala Trp Ser Pro Val Met 
                565                 570                 575     


Arg Ala Arg Lys Ser Ser Phe Asn Val Ser Asp Val Ala Arg Pro Glu 
            580                 585                 590         


Ala Ala Gly Ser Pro Pro Glu Glu Gly Gly Cys Thr Glu Gly Thr Pro 
        595                 600                 605             


Ala Lys Asp His Arg Ala Gly Arg Gly His Gln Val His Lys Ser Trp 
    610                 615                 620                 


Pro Leu Ser Ile Ser Asp Ser Asp Ser Gly Leu Asp Pro Gly Pro Gly 
625                 630                 635                 640 


Ala Gly Asp Phe Lys Lys Phe Glu Arg Thr Ser Ser Ser Gly Thr Met 
                645                 650                 655     


Ser Ser Thr Glu Glu Leu Val Asp Pro Asp Gly Gly Ala Gly Ala Ser 
            660                 665                 670         


Ala Phe Glu Gln Ala Asp Leu Asn Gly Met Thr Pro Glu Leu Pro Val 
        675                 680                 685             


Ala Val Pro Ser Gly Pro Phe Arg His Glu Gly Leu Ser Lys Ala Ala 
    690                 695                 700                 


Arg Thr His Arg Leu Arg Lys Leu Arg Thr Pro Ala Lys Cys Arg Glu 
705                 710                 715                 720 


Cys Asn Ser Tyr Val Tyr Phe Gln Gly Ala Glu Cys Glu Glu Cys Cys 
                725                 730                 735     


Leu Ala Cys His Lys Lys Cys Leu Glu Thr Leu Ala Ile Gln Cys Gly 
            740                 745                 750         


His Lys Lys Leu Gln Gly Arg Leu Gln Leu Phe Gly Gln Asp Phe Ser 
        755                 760                 765             


His Ala Ala Arg Ser Ala Pro Asp Gly Val Pro Phe Ile Val Lys Lys 
    770                 775                 780                 


Cys Val Cys Glu Ile Glu Arg Arg Ala Leu Arg Thr Lys Gly Ile Tyr 
785                 790                 795                 800 


Arg Val Asn Gly Val Lys Thr Arg Val Glu Lys Leu Cys Gln Ala Phe 
                805                 810                 815     


Glu Asn Gly Lys Glu Leu Val Glu Leu Ser Gln Ala Ser Pro His Asp 
            820                 825                 830         


Ile Ser Asn Val Leu Lys Leu Tyr Leu Arg Gln Leu Pro Glu Pro Leu 
        835                 840                 845             


Ile Ser Phe Arg Leu Tyr His Glu Leu Val Gly Leu Ala Lys Asp Ser 
    850                 855                 860                 


Leu Lys Ala Glu Ala Glu Ala Lys Ala Ala Ser Arg Gly Arg Gln Asp 
865                 870                 875                 880 


Gly Ser Glu Ser Glu Ala Val Ala Val Ala Leu Ala Gly Arg Leu Arg 
                885                 890                 895     


Glu Leu Leu Arg Asp Leu Pro Pro Glu Asn Arg Ala Ser Leu Gln Tyr 
            900                 905                 910         


Leu Leu Arg His Leu Arg Arg Ile Val Glu Val Glu Gln Asp Asn Lys 
        915                 920                 925             


Met Thr Pro Gly Asn Leu Gly Ile Val Phe Gly Pro Thr Leu Leu Arg 
    930                 935                 940                 


Pro Arg Pro Thr Glu Ala Thr Val Ser Leu Ser Ser Leu Val Asp Tyr 
945                 950                 955                 960 


Pro His Gln Ala Arg Val Ile Glu Thr Leu Ile Val His Tyr Gly Leu 
                965                 970                 975     


Val Phe Glu Glu Glu Pro Glu Glu Thr Pro Gly Gly Gln Asp Glu Ser 
            980                 985                 990         


Ser Asn Gln Arg Ala Glu Val Val  Val Gln Val Pro Tyr  Leu Glu Ala 
        995                 1000                 1005             


Gly Glu  Ala Val Val Tyr Pro  Leu Gln Glu Ala Ala  Ala Asp Gly 
    1010                 1015                 1020             


Cys Arg  Glu Ser Arg Val Val  Ser Asn Asp Ser Asp  Ser Asp Leu 
    1025                 1030                 1035             


Glu Glu  Ala Ser Glu Leu Leu  Ser Ser Ser Glu Ala  Ser Ala Leu 
    1040                 1045                 1050             


Gly His  Leu Ser Phe Leu Glu  Gln Gln Gln Ser Glu  Ala Ser Leu 
    1055                 1060                 1065             


Glu Val  Ala Ser Gly Ser His  Ser Gly Ser Glu Glu  Gln Leu Glu 
    1070                 1075                 1080             


Ala Thr  Ala Arg Glu Asp Gly  Asp Gly Asp Glu Asp  Gly Pro Ala 
    1085                 1090                 1095             


Gln Gln  Leu Ser Gly Phe Asn  Thr Asn Gln Ser Asn  Asn Val Leu 
    1100                 1105                 1110             


Gln Ala  Pro Leu Pro Pro Met  Arg Leu Arg Gly Gly  Arg Met Thr 
    1115                 1120                 1125             


Leu Gly  Ser Cys Arg Glu Arg  Gln Pro Glu Phe Val  
    1130                 1135                 1140 


<210>  1041
<211>  1152
<212>  PRT
<213>  Homo Sapiens

<400>  1041

Met Ser Arg Gly Gln Arg Val Leu Lys Gly Leu Leu Gly Trp Val Cys 
1               5                   10                  15      


Thr Trp Thr Trp Ala Trp Arg Ala Arg Leu Gly Ala Arg Gly Cys Gly 
            20                  25                  30          


Leu His Val Leu Cys Pro Arg Asp Leu Pro Leu Pro Pro Glu Glu Leu 
        35                  40                  45              


Pro Arg Lys Asp Gly Ala Asp Ala Val Phe Pro Gly Pro Ser Leu Glu 
    50                  55                  60                  


Pro Pro Ala Gly Ser Ser Gly Val Lys Ala Thr Gly Thr Leu Lys Arg 
65                  70                  75                  80  


Pro Thr Ser Leu Ser Arg His Ala Ser Ala Ala Gly Phe Pro Leu Ser 
                85                  90                  95      


Gly Ala Ala Ser Trp Thr Leu Gly Arg Ser His Arg Ser Pro Leu Thr 
            100                 105                 110         


Ala Ala Ser Pro Gly Glu Leu Pro Thr Glu Gly Ala Gly Pro Asp Val 
        115                 120                 125             


Val Glu Asp Ile Ser His Leu Leu Ala Asp Val Ala Arg Phe Ala Glu 
    130                 135                 140                 


Gly Leu Glu Lys Leu Lys Glu Cys Val Leu Arg Asp Asp Leu Leu Glu 
145                 150                 155                 160 


Ala Arg Arg Pro Arg Ala His Glu Cys Leu Gly Glu Ala Leu Arg Val 
                165                 170                 175     


Met His Gln Ile Ile Ser Lys Tyr Pro Leu Leu Asn Thr Val Glu Thr 
            180                 185                 190         


Leu Thr Ala Ala Gly Thr Leu Ile Ala Lys Val Lys Ala Phe His Tyr 
        195                 200                 205             


Glu Ser Asn Asn Asp Leu Glu Lys Gln Glu Phe Glu Lys Ala Leu Glu 
    210                 215                 220                 


Thr Ile Ala Val Ala Phe Ser Ser Thr Val Ser Glu Phe Leu Met Gly 
225                 230                 235                 240 


Glu Val Asp Ser Ser Thr Leu Leu Ala Val Pro Pro Gly Asp Ser Ser 
                245                 250                 255     


Gln Ser Met Glu Ser Leu Tyr Gly Pro Gly Ser Glu Gly Thr Pro Pro 
            260                 265                 270         


Ser Leu Glu Asp Cys Asp Ala Gly Cys Leu Pro Ala Glu Glu Val Asp 
        275                 280                 285             


Val Leu Leu Gln Arg Cys Glu Gly Gly Val Asp Ala Ala Leu Leu Tyr 
    290                 295                 300                 


Ala Lys Asn Met Ala Lys Tyr Met Lys Asp Leu Ile Ser Tyr Leu Glu 
305                 310                 315                 320 


Lys Arg Thr Thr Leu Glu Met Glu Phe Ala Lys Gly Leu Gln Lys Ile 
                325                 330                 335     


Ala His Asn Cys Arg Gln Ser Val Met Gln Glu Pro His Met Pro Leu 
            340                 345                 350         


Leu Ser Ile Tyr Ser Leu Ala Leu Glu Gln Asp Leu Glu Phe Gly His 
        355                 360                 365             


Ser Met Val Gln Ala Val Gly Thr Leu Gln Thr Gln Thr Phe Met Gln 
    370                 375                 380                 


Pro Leu Thr Leu Arg Arg Leu Glu His Glu Lys Arg Arg Lys Glu Ile 
385                 390                 395                 400 


Lys Glu Ala Trp His Arg Ala Gln Arg Lys Leu Gln Glu Ala Glu Ser 
                405                 410                 415     


Asn Leu Arg Lys Ala Lys Gln Gly Tyr Val Gln Arg Cys Glu Asp His 
            420                 425                 430         


Asp Lys Ala Arg Phe Leu Val Ala Lys Ala Glu Glu Glu Gln Ala Gly 
        435                 440                 445             


Ser Ala Pro Gly Ala Gly Ser Thr Ala Thr Lys Thr Leu Asp Lys Arg 
    450                 455                 460                 


Arg Arg Leu Glu Glu Glu Ala Lys Asn Lys Ala Glu Glu Ala Met Ala 
465                 470                 475                 480 


Thr Tyr Arg Thr Cys Val Ala Asp Ala Lys Thr Gln Lys Gln Glu Leu 
                485                 490                 495     


Glu Asp Thr Lys Val Thr Ala Leu Arg Gln Ile Gln Glu Val Ile Arg 
            500                 505                 510         


Gln Ser Asp Gln Thr Ile Lys Ser Ala Thr Ile Ser Tyr Tyr Gln Met 
        515                 520                 525             


Met His Met Gln Thr Ala Pro Leu Pro Val His Phe Gln Met Leu Cys 
    530                 535                 540                 


Glu Ser Ser Lys Leu Tyr Asp Pro Gly Gln Gln Tyr Ala Ser His Val 
545                 550                 555                 560 


Arg Gln Leu Gln Arg Asp Gln Glu Pro Asp Val His Tyr Asp Phe Glu 
                565                 570                 575     


Pro His Val Ser Ala Asn Ala Trp Ser Pro Val Met Arg Ala Arg Lys 
            580                 585                 590         


Ser Ser Phe Asn Val Ser Asp Val Ala Arg Pro Glu Ala Ala Gly Ser 
        595                 600                 605             


Pro Pro Glu Glu Gly Gly Cys Thr Glu Gly Thr Pro Ala Lys Asp His 
    610                 615                 620                 


Arg Ala Gly Arg Gly His Gln Val His Lys Ser Trp Pro Leu Ser Ile 
625                 630                 635                 640 


Ser Asp Ser Asp Ser Gly Leu Asp Pro Gly Pro Gly Ala Gly Asp Phe 
                645                 650                 655     


Lys Lys Phe Glu Arg Thr Ser Ser Ser Gly Thr Met Ser Ser Thr Glu 
            660                 665                 670         


Glu Leu Val Asp Pro Asp Gly Gly Ala Gly Ala Ser Ala Phe Glu Gln 
        675                 680                 685             


Ala Asp Leu Asn Gly Met Thr Pro Glu Leu Pro Val Ala Val Pro Ser 
    690                 695                 700                 


Gly Pro Phe Arg His Glu Gly Leu Ser Lys Ala Ala Arg Thr His Arg 
705                 710                 715                 720 


Leu Arg Lys Leu Arg Thr Pro Ala Lys Cys Arg Glu Cys Asn Ser Tyr 
                725                 730                 735     


Val Tyr Phe Gln Gly Ala Glu Cys Glu Glu Cys Cys Leu Ala Cys His 
            740                 745                 750         


Lys Lys Cys Leu Glu Thr Leu Ala Ile Gln Cys Gly His Lys Lys Leu 
        755                 760                 765             


Gln Gly Arg Leu Gln Leu Phe Gly Gln Asp Phe Ser His Ala Ala Arg 
    770                 775                 780                 


Ser Ala Pro Asp Gly Val Pro Phe Ile Val Lys Lys Cys Val Cys Glu 
785                 790                 795                 800 


Ile Glu Arg Arg Ala Leu Arg Thr Lys Gly Ile Tyr Arg Val Asn Gly 
                805                 810                 815     


Val Lys Thr Arg Val Glu Lys Leu Cys Gln Ala Phe Glu Asn Gly Lys 
            820                 825                 830         


Glu Leu Val Glu Leu Ser Gln Ala Ser Pro His Asp Ile Ser Asn Val 
        835                 840                 845             


Leu Lys Leu Tyr Leu Arg Gln Leu Pro Glu Pro Leu Ile Ser Phe Arg 
    850                 855                 860                 


Leu Tyr His Glu Leu Val Gly Leu Ala Lys Asp Ser Leu Lys Ala Glu 
865                 870                 875                 880 


Ala Glu Ala Lys Ala Ala Ser Arg Gly Arg Gln Asp Gly Ser Glu Ser 
                885                 890                 895     


Glu Ala Val Ala Val Ala Leu Ala Gly Arg Leu Arg Glu Leu Leu Arg 
            900                 905                 910         


Asp Leu Pro Pro Glu Asn Arg Ala Ser Leu Gln Tyr Leu Leu Arg His 
        915                 920                 925             


Leu Arg Arg Ile Val Glu Val Glu Gln Asp Asn Lys Met Thr Pro Gly 
    930                 935                 940                 


Asn Leu Gly Ile Val Phe Gly Pro Thr Leu Leu Arg Pro Arg Pro Thr 
945                 950                 955                 960 


Glu Ala Thr Val Ser Leu Ser Ser Leu Val Asp Tyr Pro His Gln Ala 
                965                 970                 975     


Arg Val Ile Glu Thr Leu Ile Val His Tyr Gly Leu Val Phe Glu Glu 
            980                 985                 990         


Glu Pro Glu Glu Thr Pro Gly Gly  Gln Asp Glu Ser Ser  Asn Gln Arg 
        995                 1000                 1005             


Ala Glu  Val Val Val Gln Val  Pro Tyr Leu Glu Ala  Gly Glu Ala 
    1010                 1015                 1020             


Val Val  Tyr Pro Leu Gln Glu  Ala Ala Ala Asp Gly  Cys Arg Glu 
    1025                 1030                 1035             


Ser Arg  Val Val Ser Asn Asp  Ser Asp Ser Asp Leu  Glu Glu Ala 
    1040                 1045                 1050             


Ser Glu  Leu Leu Ser Ser Ser  Glu Ala Ser Ala Leu  Gly His Leu 
    1055                 1060                 1065             


Ser Phe  Leu Glu Gln Gln Gln  Ser Glu Ala Ser Leu  Glu Val Ala 
    1070                 1075                 1080             


Ser Gly  Ser His Ser Gly Ser  Glu Glu Gln Leu Glu  Ala Thr Ala 
    1085                 1090                 1095             


Arg Glu  Asp Gly Asp Gly Asp  Glu Asp Gly Pro Ala  Gln Gln Leu 
    1100                 1105                 1110             


Ser Gly  Phe Asn Thr Asn Gln  Ser Asn Asn Val Leu  Gln Ala Pro 
    1115                 1120                 1125             


Leu Pro  Pro Met Arg Leu Arg  Gly Gly Arg Met Thr  Leu Gly Ser 
    1130                 1135                 1140             


Cys Arg  Glu Arg Gln Pro Glu  Phe Val 
    1145                 1150         


<210>  1042
<211>  170
<212>  PRT
<213>  Homo Sapiens

<400>  1042

Met Val Gly Ser Thr Pro His Phe Gly Asp Pro Cys Ala Gly Ser Pro 
1               5                   10                  15      


Gly Pro Gly Gly Arg Gly Asp Pro Asp Gly Arg Gly Asp Pro Asp Gly 
            20                  25                  30          


Gln Gly Pro Glu Leu Pro Arg Lys Asp Gly Ala Asp Ala Val Phe Pro 
        35                  40                  45              


Gly Pro Ser Leu Glu Pro Pro Ala Gly Ser Ser Gly Val Lys Ala Thr 
    50                  55                  60                  


Gly Thr Leu Lys Arg Pro Thr Ser Leu Ser Arg His Ala Ser Ala Ala 
65                  70                  75                  80  


Gly Phe Pro Leu Ser Gly Ala Ala Ser Trp Thr Leu Gly Arg Ser His 
                85                  90                  95      


Arg Ser Pro Leu Thr Ala Ala Ser Pro Gly Glu Leu Pro Thr Glu Gly 
            100                 105                 110         


Ala Gly Pro Asp Val Val Glu Asp Ile Ser His Leu Leu Ala Asp Val 
        115                 120                 125             


Ala Arg Phe Ala Glu Gly Leu Glu Lys Leu Lys Glu Cys Val Leu Arg 
    130                 135                 140                 


Asp Asp Leu Leu Glu Ala Arg Arg Pro Arg Ala His Glu Cys Leu Gly 
145                 150                 155                 160 


Glu Ala Leu Arg Val Met His Gln Ile Ile 
                165                 170 


<210>  1043
<211>  601
<212>  PRT
<213>  Homo Sapiens

<400>  1043

Leu Glu Leu Tyr Asp Leu Gln Ile Leu Gly Thr Lys Pro Pro Met Asn 
1               5                   10                  15      


Ser Asp Thr His Arg Asn Phe Asp Pro Thr Ala Thr Leu Arg Asn Gln 
            20                  25                  30          


Gly Asp Phe Thr Trp Asn Ser Met Ser Gly Arg Ser Val Arg Leu Arg 
        35                  40                  45              


Ser Val Pro Ile Gln Ser Leu Ser Glu Leu Glu Arg Ala Arg Leu Gln 
    50                  55                  60                  


Glu Val Ala Phe Tyr Gln Leu Gln Gln Asp Cys Asp Leu Ser Cys Gln 
65                  70                  75                  80  


Ile Thr Ile Pro Lys Asp Gly Gln Lys Arg Lys Lys Ser Leu Arg Lys 
                85                  90                  95      


Lys Leu Asp Ser Leu Gly Lys Glu Lys Asn Lys Asp Lys Glu Phe Ile 
            100                 105                 110         


Pro Gln Ala Phe Gly Met Pro Leu Ser Gln Val Ile Ala Asn Asp Arg 
        115                 120                 125             


Ala Tyr Lys Leu Lys Gln Asp Leu Gln Arg Asp Glu Gln Lys Asp Ala 
    130                 135                 140                 


Ser Asp Phe Val Ala Ser Leu Leu Pro Phe Gly Asn Lys Arg Gln Asn 
145                 150                 155                 160 


Lys Glu Leu Ser Ser Ser Asn Ser Ser Leu Ser Ser Thr Ser Glu Thr 
                165                 170                 175     


Pro Asn Glu Ser Thr Ser Pro Asn Thr Pro Glu Pro Ala Pro Arg Ala 
            180                 185                 190         


Arg Arg Arg Gly Ala Met Ser Val Asp Ser Ile Thr Asp Leu Asp Asp 
        195                 200                 205             


Asn Gln Ser Arg Leu Leu Glu Ala Leu Gln Leu Ser Leu Pro Ala Glu 
    210                 215                 220                 


Ala Gln Ser Lys Lys Glu Lys Ala Arg Asp Lys Lys Leu Ser Leu Asn 
225                 230                 235                 240 


Pro Ile Tyr Arg Gln Val Pro Arg Leu Val Asp Ser Cys Cys Gln His 
                245                 250                 255     


Leu Glu Lys His Gly Leu Gln Thr Val Gly Ile Phe Arg Val Gly Ser 
            260                 265                 270         


Ser Lys Lys Arg Val Arg Gln Leu Arg Glu Glu Phe Asp Arg Gly Ile 
        275                 280                 285             


Asp Val Ser Leu Glu Glu Glu His Ser Val His Asp Val Ala Ala Leu 
    290                 295                 300                 


Leu Lys Glu Phe Leu Arg Asp Met Pro Asp Pro Leu Leu Thr Arg Glu 
305                 310                 315                 320 


Leu Tyr Thr Ala Phe Ile Asn Thr Leu Leu Leu Glu Pro Glu Glu Gln 
                325                 330                 335     


Leu Gly Thr Leu Gln Leu Leu Ile Tyr Leu Leu Pro Pro Cys Asn Cys 
            340                 345                 350         


Asp Thr Leu His Arg Leu Leu Gln Phe Leu Ser Ile Val Ala Arg His 
        355                 360                 365             


Ala Asp Asp Asn Ile Ser Lys Asp Gly Gln Glu Val Thr Gly Asn Lys 
    370                 375                 380                 


Met Thr Ser Leu Asn Leu Ala Thr Ile Phe Gly Pro Asn Leu Leu His 
385                 390                 395                 400 


Lys Gln Lys Ser Ser Asp Lys Glu Phe Ser Val Gln Ser Ser Ala Arg 
                405                 410                 415     


Ala Glu Glu Ser Thr Ala Ile Ile Ala Val Val Gln Lys Met Ile Glu 
            420                 425                 430         


Asn Tyr Glu Ala Leu Phe Met Val Pro Pro Asp Leu Gln Asn Glu Val 
        435                 440                 445             


Leu Ile Ser Leu Leu Glu Thr Asp Pro Asp Val Val Asp Tyr Leu Leu 
    450                 455                 460                 


Arg Arg Lys Ala Ser Gln Ser Ser Ser Pro Asp Met Leu Gln Ser Glu 
465                 470                 475                 480 


Val Ser Phe Ser Val Gly Gly Arg His Ser Ser Thr Asp Ser Asn Lys 
                485                 490                 495     


Ala Ser Ser Gly Asp Ile Ser Pro Tyr Asp Asn Asn Ser Pro Val Leu 
            500                 505                 510         


Ser Glu Arg Ser Leu Leu Ala Met Gln Glu Asp Ala Ala Pro Gly Gly 
        515                 520                 525             


Ser Glu Lys Leu Tyr Arg Val Pro Gly Gln Phe Met Leu Val Gly His 
    530                 535                 540                 


Leu Ser Ser Ser Lys Ser Arg Glu Ser Ser Pro Gly Pro Arg Leu Gly 
545                 550                 555                 560 


Lys Gly Asn Trp Ser Leu Ala Ser Arg Arg Trp Pro Lys Gln Ala Thr 
                565                 570                 575     


Leu Leu Leu Leu His Val Ala Trp Cys Gly Ala Leu Arg Thr Phe Ser 
            580                 585                 590         


Ser Ser Leu Pro Tyr Leu Met Phe Leu 
        595                 600     


<210>  1044
<211>  974
<212>  PRT
<213>  Homo Sapiens

<400>  1044

Met Ser Ala Gln Ser Leu Leu His Ser Val Phe Ser Cys Ser Ser Pro 
1               5                   10                  15      


Ala Ser Ser Ser Ala Ala Ser Ala Lys Gly Phe Ser Lys Arg Lys Leu 
            20                  25                  30          


Arg Gln Thr Arg Ser Leu Asp Pro Ala Leu Ile Gly Gly Cys Gly Ser 
        35                  40                  45              


Asp Glu Ala Gly Ala Glu Gly Ser Ala Arg Gly Ala Thr Ala Gly Arg 
    50                  55                  60                  


Leu Tyr Ser Pro Ser Leu Pro Ala Glu Ser Leu Gly Pro Arg Leu Ala 
65                  70                  75                  80  


Ser Ser Ser Arg Gly Pro Pro Pro Arg Ala Thr Arg Leu Pro Pro Pro 
                85                  90                  95      


Gly Pro Leu Cys Ser Ser Phe Ser Thr Pro Ser Thr Pro Gln Glu Lys 
            100                 105                 110         


Ser Pro Ser Gly Ser Phe His Phe Asp Tyr Glu Val Pro Leu Gly Arg 
        115                 120                 125             


Gly Gly Leu Lys Lys Ser Met Ala Trp Asp Leu Pro Ser Val Leu Ala 
    130                 135                 140                 


Gly Pro Ala Ser Ser Arg Ser Ala Ser Ser Ile Leu Cys Ser Ser Gly 
145                 150                 155                 160 


Gly Gly Pro Asn Gly Ile Phe Ala Ser Pro Arg Arg Trp Leu Gln Gln 
                165                 170                 175     


Arg Lys Phe Gln Ser Pro Pro Asp Ser Arg Gly His Pro Tyr Val Val 
            180                 185                 190         


Trp Lys Ser Glu Gly Asp Phe Thr Trp Asn Ser Met Ser Gly Arg Ser 
        195                 200                 205             


Val Arg Leu Arg Ser Val Pro Ile Gln Ser Leu Ser Glu Leu Glu Arg 
    210                 215                 220                 


Ala Arg Leu Gln Glu Val Ala Phe Tyr Gln Leu Gln Gln Asp Cys Asp 
225                 230                 235                 240 


Leu Ser Cys Gln Ile Thr Ile Pro Lys Asp Gly Gln Lys Arg Lys Lys 
                245                 250                 255     


Ser Leu Arg Lys Lys Leu Asp Ser Leu Gly Lys Glu Lys Asn Lys Asp 
            260                 265                 270         


Lys Glu Phe Ile Pro Gln Ala Phe Gly Met Pro Leu Ser Gln Val Ile 
        275                 280                 285             


Ala Asn Asp Arg Ala Tyr Lys Leu Lys Gln Asp Leu Gln Arg Asp Glu 
    290                 295                 300                 


Gln Lys Asp Ala Ser Asp Phe Val Ala Ser Leu Leu Pro Phe Gly Asn 
305                 310                 315                 320 


Lys Arg Gln Asn Lys Glu Leu Ser Ser Ser Asn Ser Ser Leu Ser Ser 
                325                 330                 335     


Thr Ser Glu Thr Pro Asn Glu Ser Thr Ser Pro Asn Thr Pro Glu Pro 
            340                 345                 350         


Ala Pro Arg Ala Arg Arg Arg Gly Ala Met Ser Val Asp Ser Ile Thr 
        355                 360                 365             


Asp Leu Asp Asp Asn Gln Ser Arg Leu Leu Glu Ala Leu Gln Leu Ser 
    370                 375                 380                 


Leu Pro Ala Glu Ala Gln Ser Lys Lys Glu Lys Ala Arg Asp Lys Lys 
385                 390                 395                 400 


Leu Ser Leu Asn Pro Ile Tyr Arg Gln Val Pro Arg Leu Val Asp Ser 
                405                 410                 415     


Cys Cys Gln His Leu Glu Lys His Gly Leu Gln Thr Val Gly Ile Phe 
            420                 425                 430         


Arg Val Gly Ser Ser Lys Lys Arg Val Arg Gln Leu Arg Glu Glu Phe 
        435                 440                 445             


Asp Arg Gly Ile Asp Val Ser Leu Glu Glu Glu His Ser Val His Asp 
    450                 455                 460                 


Val Ala Ala Leu Leu Lys Glu Phe Leu Arg Asp Met Pro Asp Pro Leu 
465                 470                 475                 480 


Leu Thr Arg Glu Leu Tyr Thr Ala Phe Ile Asn Thr Leu Leu Leu Glu 
                485                 490                 495     


Pro Glu Glu Gln Leu Gly Thr Leu Gln Leu Leu Ile Tyr Leu Leu Pro 
            500                 505                 510         


Pro Cys Asn Cys Asp Thr Leu His Arg Leu Leu Gln Phe Leu Ser Ile 
        515                 520                 525             


Val Ala Arg His Ala Asp Asp Asn Ile Ser Lys Asp Gly Gln Glu Val 
    530                 535                 540                 


Thr Gly Asn Lys Met Thr Ser Leu Asn Leu Ala Thr Ile Phe Gly Pro 
545                 550                 555                 560 


Asn Leu Leu His Lys Gln Lys Ser Ser Asp Lys Glu Phe Ser Val Gln 
                565                 570                 575     


Ser Ser Ala Arg Ala Glu Glu Ser Thr Ala Ile Ile Ala Val Val Gln 
            580                 585                 590         


Lys Met Ile Glu Asn Tyr Glu Ala Leu Phe Met Val Pro Pro Asp Leu 
        595                 600                 605             


Gln Asn Glu Val Leu Ile Ser Leu Leu Glu Thr Asp Pro Asp Val Val 
    610                 615                 620                 


Asp Tyr Leu Leu Arg Arg Lys Ala Ser Gln Ser Ser Ser Pro Asp Met 
625                 630                 635                 640 


Leu Gln Ser Glu Val Ser Phe Ser Val Gly Gly Arg His Ser Ser Thr 
                645                 650                 655     


Asp Ser Asn Lys Ala Ser Ser Gly Asp Ile Ser Pro Tyr Asp Asn Asn 
            660                 665                 670         


Ser Pro Val Leu Ser Glu Arg Ser Leu Leu Ala Met Gln Glu Asp Ala 
        675                 680                 685             


Ala Pro Gly Gly Ser Glu Lys Leu Tyr Arg Val Pro Gly Gln Phe Met 
    690                 695                 700                 


Leu Val Gly His Leu Ser Ser Ser Lys Ser Arg Glu Ser Ser Pro Gly 
705                 710                 715                 720 


Pro Arg Leu Gly Lys Asp Leu Ser Glu Glu Pro Phe Asp Ile Trp Gly 
                725                 730                 735     


Thr Trp His Ser Thr Leu Lys Ser Gly Ser Lys Asp Pro Gly Met Thr 
            740                 745                 750         


Gly Ser Ser Gly Asp Ile Phe Glu Ser Ser Ser Leu Arg Ala Gly Pro 
        755                 760                 765             


Cys Ser Leu Ser Gln Gly Asn Leu Ser Pro Asn Trp Pro Arg Trp Gln 
    770                 775                 780                 


Gly Ser Pro Ala Glu Leu Asp Ser Asp Thr Gln Gly Ala Arg Arg Thr 
785                 790                 795                 800 


Gln Ala Ala Ala Pro Ala Thr Glu Gly Arg Ala His Pro Ala Val Ser 
                805                 810                 815     


Arg Ala Cys Ser Thr Pro His Val Gln Val Ala Gly Lys Ala Glu Arg 
            820                 825                 830         


Pro Thr Ala Arg Ser Glu Gln Tyr Leu Thr Leu Ser Gly Ala His Asp 
        835                 840                 845             


Leu Ser Glu Ser Glu Leu Asp Val Ala Gly Leu Gln Ser Arg Ala Thr 
    850                 855                 860                 


Pro Gln Cys Gln Arg Pro His Gly Ser Gly Arg Asp Asp Lys Arg Pro 
865                 870                 875                 880 


Pro Pro Pro Tyr Pro Gly Pro Gly Lys Pro Ala Ala Ala Ala Ala Trp 
                885                 890                 895     


Ile Gln Gly Pro Pro Glu Gly Val Glu Thr Pro Thr Asp Gln Gly Gly 
            900                 905                 910         


Gln Ala Ala Glu Arg Glu Gln Gln Val Thr Gln Lys Lys Leu Ser Ser 
        915                 920                 925             


Ala Asn Ser Leu Pro Ala Gly Glu Gln Asp Ser Pro Arg Leu Gly Asp 
    930                 935                 940                 


Ala Gly Trp Leu Asp Trp Gln Arg Glu Arg Trp Gln Ile Trp Glu Leu 
945                 950                 955                 960 


Leu Ser Thr Asp Asn Pro Asp Ala Leu Pro Glu Thr Leu Val 
                965                 970                 


<210>  1045
<211>  765
<212>  PRT
<213>  Homo Sapiens

<400>  1045

Met Ser Ala Gln Ser Leu Leu His Ser Val Phe Ser Cys Ser Ser Pro 
1               5                   10                  15      


Ala Ser Ser Ser Ala Ala Ser Ala Lys Gly Phe Ser Lys Arg Lys Leu 
            20                  25                  30          


Arg Gln Thr Arg Ser Leu Asp Pro Ala Leu Ile Gly Gly Cys Gly Ser 
        35                  40                  45              


Asp Glu Ala Gly Ala Glu Gly Ser Ala Arg Gly Ala Thr Ala Gly Arg 
    50                  55                  60                  


Leu Tyr Ser Pro Ser Leu Pro Ala Glu Ser Leu Gly Pro Arg Leu Ala 
65                  70                  75                  80  


Ser Ser Ser Arg Gly Pro Pro Pro Arg Ala Thr Arg Leu Pro Pro Pro 
                85                  90                  95      


Gly Pro Leu Cys Ser Ser Phe Ser Thr Pro Ser Thr Pro Gln Glu Lys 
            100                 105                 110         


Ser Pro Ser Gly Ser Phe His Phe Asp Tyr Glu Val Pro Leu Gly Arg 
        115                 120                 125             


Gly Gly Leu Lys Lys Ser Met Ala Trp Asp Leu Pro Ser Val Leu Ala 
    130                 135                 140                 


Gly Pro Ala Ser Ser Arg Ser Ala Ser Ser Ile Leu Cys Ser Ser Gly 
145                 150                 155                 160 


Gly Gly Pro Asn Gly Ile Phe Ala Ser Pro Arg Arg Trp Leu Gln Gln 
                165                 170                 175     


Arg Lys Phe Gln Ser Pro Pro Asp Ser Arg Gly His Pro Tyr Val Val 
            180                 185                 190         


Trp Lys Ser Glu Gly Asp Phe Thr Trp Asn Ser Met Ser Gly Arg Ser 
        195                 200                 205             


Val Arg Leu Arg Ser Val Pro Ile Gln Ser Leu Ser Glu Leu Glu Arg 
    210                 215                 220                 


Ala Arg Leu Gln Glu Val Ala Phe Tyr Gln Leu Gln Gln Asp Cys Asp 
225                 230                 235                 240 


Leu Ser Cys Gln Ile Thr Ile Pro Lys Asp Gly Gln Lys Arg Lys Lys 
                245                 250                 255     


Ser Leu Arg Lys Lys Leu Asp Ser Leu Gly Lys Glu Lys Asn Lys Asp 
            260                 265                 270         


Lys Glu Phe Ile Pro Gln Ala Phe Gly Met Pro Leu Ser Gln Val Ile 
        275                 280                 285             


Ala Asn Asp Arg Ala Tyr Lys Leu Lys Gln Asp Leu Gln Arg Asp Glu 
    290                 295                 300                 


Gln Lys Asp Ala Ser Asp Phe Val Ala Ser Leu Leu Pro Phe Gly Asn 
305                 310                 315                 320 


Lys Arg Gln Asn Lys Glu Leu Ser Ser Ser Asn Ser Ser Leu Ser Ser 
                325                 330                 335     


Thr Ser Glu Thr Pro Asn Glu Ser Thr Ser Pro Asn Thr Pro Glu Pro 
            340                 345                 350         


Ala Pro Arg Ala Arg Arg Arg Gly Ala Met Ser Val Asp Ser Ile Thr 
        355                 360                 365             


Asp Leu Asp Asp Asn Gln Ser Arg Leu Leu Glu Ala Leu Gln Leu Ser 
    370                 375                 380                 


Leu Pro Ala Glu Ala Gln Ser Lys Lys Glu Lys Ala Arg Asp Lys Lys 
385                 390                 395                 400 


Leu Ser Leu Asn Pro Ile Tyr Arg Gln Val Pro Arg Leu Val Asp Ser 
                405                 410                 415     


Cys Cys Gln His Leu Glu Lys His Gly Leu Gln Thr Val Gly Ile Phe 
            420                 425                 430         


Arg Val Gly Ser Ser Lys Lys Arg Val Arg Gln Leu Arg Glu Glu Phe 
        435                 440                 445             


Asp Arg Gly Ile Asp Val Ser Leu Glu Glu Glu His Ser Val His Asp 
    450                 455                 460                 


Val Ala Ala Leu Leu Lys Glu Phe Leu Arg Asp Met Pro Asp Pro Leu 
465                 470                 475                 480 


Leu Thr Arg Glu Leu Tyr Thr Ala Phe Ile Asn Thr Leu Leu Leu Glu 
                485                 490                 495     


Pro Glu Glu Gln Leu Gly Thr Leu Gln Leu Leu Ile Tyr Leu Leu Pro 
            500                 505                 510         


Pro Cys Asn Cys Asp Thr Leu His Arg Leu Leu Gln Phe Leu Ser Ile 
        515                 520                 525             


Val Ala Arg His Ala Asp Asp Asn Ile Ser Lys Asp Gly Gln Glu Val 
    530                 535                 540                 


Thr Gly Asn Lys Met Thr Ser Leu Asn Leu Ala Thr Ile Phe Gly Pro 
545                 550                 555                 560 


Asn Leu Leu His Lys Gln Lys Ser Ser Asp Lys Glu Phe Ser Val Gln 
                565                 570                 575     


Ser Ser Ala Arg Ala Glu Glu Ser Thr Ala Ile Ile Ala Val Val Gln 
            580                 585                 590         


Lys Met Ile Glu Asn Tyr Glu Ala Leu Phe Met Val Pro Pro Asp Leu 
        595                 600                 605             


Gln Asn Glu Val Leu Ile Ser Leu Leu Glu Thr Asp Pro Asp Val Val 
    610                 615                 620                 


Asp Tyr Leu Leu Arg Arg Lys Ala Ser Gln Ser Ser Ser Pro Asp Met 
625                 630                 635                 640 


Leu Gln Ser Glu Val Ser Phe Ser Val Gly Gly Arg His Ser Ser Thr 
                645                 650                 655     


Asp Ser Asn Lys Ala Ser Ser Gly Asp Ile Ser Pro Tyr Asp Asn Asn 
            660                 665                 670         


Ser Pro Val Leu Ser Glu Arg Ser Leu Leu Ala Met Gln Glu Asp Ala 
        675                 680                 685             


Ala Pro Gly Gly Ser Glu Lys Leu Tyr Arg Val Pro Gly Gln Phe Met 
    690                 695                 700                 


Leu Val Gly His Leu Ser Ser Ser Lys Ser Arg Glu Ser Ser Pro Gly 
705                 710                 715                 720 


Pro Arg Leu Gly Lys Gly Asn Trp Ser Leu Ala Ser Arg Arg Trp Pro 
                725                 730                 735     


Lys Gln Ala Thr Leu Leu Leu Leu His Val Ala Trp Cys Gly Ala Leu 
            740                 745                 750         


Arg Thr Phe Ser Ser Ser Leu Pro Tyr Leu Met Phe Leu 
        755                 760                 765 


<210>  1046
<211>  690
<212>  PRT
<213>  Homo Sapiens

<400>  1046

Met Ser Ala Gln Ser Leu Leu His Ser Val Phe Ser Cys Ser Ser Pro 
1               5                   10                  15      


Ala Ser Ser Ser Ala Ala Ser Ala Lys Gly Phe Ser Lys Arg Lys Leu 
            20                  25                  30          


Arg Gln Thr Arg Ser Leu Asp Pro Ala Leu Ile Gly Gly Cys Gly Ser 
        35                  40                  45              


Asp Glu Ala Gly Ala Glu Gly Ser Ala Arg Gly Ala Thr Ala Gly Arg 
    50                  55                  60                  


Leu Tyr Ser Pro Ser Leu Pro Ala Glu Ser Leu Gly Pro Arg Leu Ala 
65                  70                  75                  80  


Ser Ser Ser Arg Gly Pro Pro Pro Arg Ala Thr Arg Leu Pro Pro Pro 
                85                  90                  95      


Gly Pro Leu Cys Ser Ser Phe Ser Thr Pro Ser Thr Pro Gln Glu Lys 
            100                 105                 110         


Ser Pro Ser Gly Ser Phe His Phe Asp Tyr Glu Val Pro Leu Gly Arg 
        115                 120                 125             


Gly Gly Leu Lys Lys Ser Met Ala Trp Asp Leu Pro Ser Val Leu Ala 
    130                 135                 140                 


Gly Pro Ala Ser Ser Arg Ser Ala Ser Ser Ile Leu Cys Ser Ser Gly 
145                 150                 155                 160 


Gly Gly Pro Asn Gly Ile Phe Ala Ser Pro Arg Arg Trp Leu Gln Gln 
                165                 170                 175     


Arg Lys Phe Gln Ser Pro Pro Asp Ser Arg Gly His Pro Tyr Val Val 
            180                 185                 190         


Trp Lys Ser Glu Leu Glu Leu Tyr Asp Leu Gln Ile Leu Gly Thr Lys 
        195                 200                 205             


Pro Pro Met Asn Ser Asp Thr His Arg Asn Phe Asp Pro Thr Ala Thr 
    210                 215                 220                 


Leu Arg Asn Gln Gly Asp Phe Thr Trp Asn Ser Met Ser Gly Arg Ser 
225                 230                 235                 240 


Val Arg Leu Arg Ser Val Pro Ile Gln Ser Leu Ser Glu Leu Glu Arg 
                245                 250                 255     


Ala Arg Leu Gln Glu Val Ala Phe Tyr Gln Leu Gln Gln Asp Cys Asp 
            260                 265                 270         


Leu Ser Cys Gln Ile Thr Ile Pro Lys Asp Gly Gln Lys Arg Lys Lys 
        275                 280                 285             


Ser Leu Arg Lys Lys Leu Asp Ser Leu Gly Lys Glu Lys Asn Lys Asp 
    290                 295                 300                 


Lys Glu Phe Ile Pro Gln Ala Phe Gly Met Pro Leu Ser Gln Val Ile 
305                 310                 315                 320 


Ala Asn Asp Arg Ala Tyr Lys Leu Lys Gln Asp Leu Gln Arg Asp Glu 
                325                 330                 335     


Gln Lys Asp Ala Ser Asp Phe Val Ala Ser Leu Leu Pro Phe Gly Asn 
            340                 345                 350         


Lys Arg Gln Asn Lys Glu Leu Ser Ser Ser Asn Ser Ser Leu Ser Ser 
        355                 360                 365             


Thr Ser Glu Thr Pro Asn Glu Ser Thr Ser Pro Asn Thr Pro Glu Pro 
    370                 375                 380                 


Ala Pro Arg Ala Arg Arg Arg Gly Ala Met Ser Val Asp Ser Ile Thr 
385                 390                 395                 400 


Asp Leu Asp Asp Asn Gln Ser Arg Leu Leu Glu Ala Leu Gln Leu Ser 
                405                 410                 415     


Leu Pro Ala Glu Ala Gln Ser Lys Lys Glu Lys Ala Arg Asp Lys Lys 
            420                 425                 430         


Leu Ser Leu Asn Pro Ile Tyr Arg Gln Val Pro Arg Leu Val Asp Ser 
        435                 440                 445             


Cys Cys Gln His Leu Glu Lys His Gly Leu Gln Thr Val Gly Ile Phe 
    450                 455                 460                 


Arg Val Gly Ser Ser Lys Lys Arg Val Arg Gln Leu Arg Glu Glu Phe 
465                 470                 475                 480 


Asp Arg Gly Ile Asp Val Ser Leu Glu Glu Glu His Ser Val His Asp 
                485                 490                 495     


Val Ala Ala Leu Leu Lys Glu Phe Leu Arg Asp Met Pro Asp Pro Leu 
            500                 505                 510         


Leu Thr Arg Glu Leu Tyr Thr Ala Phe Ile Asn Thr Leu Leu Leu Glu 
        515                 520                 525             


Pro Glu Glu Gln Leu Gly Thr Leu Gln Leu Leu Ile Tyr Leu Leu Pro 
    530                 535                 540                 


Pro Cys Asn Cys Asp Thr Leu His Arg Leu Leu Gln Phe Leu Ser Ile 
545                 550                 555                 560 


Val Ala Arg His Ala Asp Asp Asn Ile Ser Lys Asp Gly Gln Glu Val 
                565                 570                 575     


Thr Gly Asn Lys Met Thr Ser Leu Asn Leu Ala Thr Ile Phe Gly Pro 
            580                 585                 590         


Asn Leu Leu His Lys Gln Lys Ser Ser Asp Lys Glu Phe Ser Val Gln 
        595                 600                 605             


Ser Ser Ala Arg Ala Glu Glu Ser Thr Ala Ile Ile Ala Val Val Gln 
    610                 615                 620                 


Lys Met Ile Glu Asn Tyr Glu Ala Leu Phe Met Val Pro Pro Asp Leu 
625                 630                 635                 640 


Gln Asn Glu Val Leu Ile Ser Leu Leu Glu Thr Asp Pro Asp Val Val 
                645                 650                 655     


Asp Tyr Leu Leu Arg Arg Lys Ala Ser Gln Ser Ser Thr Ser Ser Val 
            660                 665                 670         


Leu Pro Ala Ala Val Gln Ala Cys Pro Gln Tyr Pro Ala Ser Met Phe 
        675                 680                 685             


Thr Pro 
    690 


<210>  1047
<211>  771
<212>  PRT
<213>  Homo Sapiens

<400>  1047

Met Ser Gly Arg Ser Val Arg Leu Arg Ser Val Pro Ile Gln Ser Leu 
1               5                   10                  15      


Ser Glu Leu Glu Arg Ala Arg Leu Gln Glu Val Ala Phe Tyr Gln Leu 
            20                  25                  30          


Gln Gln Asp Cys Asp Leu Ser Cys Gln Ile Thr Ile Pro Lys Asp Gly 
        35                  40                  45              


Gln Lys Arg Lys Lys Ser Leu Arg Lys Lys Leu Asp Ser Leu Gly Lys 
    50                  55                  60                  


Glu Lys Asn Lys Asp Lys Glu Phe Ile Pro Gln Ala Phe Gly Met Pro 
65                  70                  75                  80  


Leu Ser Gln Val Ile Ala Asn Asp Arg Ala Tyr Lys Leu Lys Gln Asp 
                85                  90                  95      


Leu Gln Arg Asp Glu Gln Lys Asp Ala Ser Asp Phe Val Ala Ser Leu 
            100                 105                 110         


Leu Pro Phe Gly Asn Lys Arg Gln Asn Lys Glu Leu Ser Ser Ser Asn 
        115                 120                 125             


Ser Ser Leu Ser Ser Thr Ser Glu Thr Pro Asn Glu Ser Thr Ser Pro 
    130                 135                 140                 


Asn Thr Pro Glu Pro Ala Pro Arg Ala Arg Arg Arg Gly Ala Met Ser 
145                 150                 155                 160 


Val Asp Ser Ile Thr Asp Leu Asp Asp Asn Gln Ser Arg Leu Leu Glu 
                165                 170                 175     


Ala Leu Gln Leu Ser Leu Pro Ala Glu Ala Gln Ser Lys Lys Glu Lys 
            180                 185                 190         


Ala Arg Asp Lys Lys Leu Ser Leu Asn Pro Ile Tyr Arg Gln Val Pro 
        195                 200                 205             


Arg Leu Val Asp Ser Cys Cys Gln His Leu Glu Lys His Gly Leu Gln 
    210                 215                 220                 


Thr Val Gly Ile Phe Arg Val Gly Ser Ser Lys Lys Arg Val Arg Gln 
225                 230                 235                 240 


Leu Arg Glu Glu Phe Asp Arg Gly Ile Asp Val Ser Leu Glu Glu Glu 
                245                 250                 255     


His Ser Val His Asp Val Ala Ala Leu Leu Lys Glu Phe Leu Arg Asp 
            260                 265                 270         


Met Pro Asp Pro Leu Leu Thr Arg Glu Leu Tyr Thr Ala Phe Ile Asn 
        275                 280                 285             


Thr Leu Leu Leu Glu Pro Glu Glu Gln Leu Gly Thr Leu Gln Leu Leu 
    290                 295                 300                 


Ile Tyr Leu Leu Pro Pro Cys Asn Cys Asp Thr Leu His Arg Leu Leu 
305                 310                 315                 320 


Gln Phe Leu Ser Ile Val Ala Arg His Ala Asp Asp Asn Ile Ser Lys 
                325                 330                 335     


Asp Gly Gln Glu Val Thr Gly Asn Lys Met Thr Ser Leu Asn Leu Ala 
            340                 345                 350         


Thr Ile Phe Gly Pro Asn Leu Leu His Lys Gln Lys Ser Ser Asp Lys 
        355                 360                 365             


Glu Phe Ser Val Gln Ser Ser Ala Arg Ala Glu Glu Ser Thr Ala Ile 
    370                 375                 380                 


Ile Ala Val Val Gln Lys Met Ile Glu Asn Tyr Glu Ala Leu Phe Met 
385                 390                 395                 400 


Val Pro Pro Asp Leu Gln Asn Glu Val Leu Ile Ser Leu Leu Glu Thr 
                405                 410                 415     


Asp Pro Asp Val Val Asp Tyr Leu Leu Arg Arg Lys Ala Ser Gln Ser 
            420                 425                 430         


Ser Ser Pro Asp Met Leu Gln Ser Glu Val Ser Phe Ser Val Gly Gly 
        435                 440                 445             


Arg His Ser Ser Thr Asp Ser Asn Lys Ala Ser Ser Gly Asp Ile Ser 
    450                 455                 460                 


Pro Tyr Asp Asn Asn Ser Pro Val Leu Ser Glu Arg Ser Leu Leu Ala 
465                 470                 475                 480 


Met Gln Glu Asp Ala Ala Pro Gly Gly Ser Glu Lys Leu Tyr Arg Val 
                485                 490                 495     


Pro Gly Gln Phe Met Leu Val Gly His Leu Ser Ser Ser Lys Ser Arg 
            500                 505                 510         


Glu Ser Ser Pro Gly Pro Arg Leu Gly Lys Asp Leu Ser Glu Glu Pro 
        515                 520                 525             


Phe Asp Ile Trp Gly Thr Trp His Ser Thr Leu Lys Ser Gly Ser Lys 
    530                 535                 540                 


Asp Pro Gly Met Thr Gly Ser Ser Gly Asp Ile Phe Glu Ser Ser Ser 
545                 550                 555                 560 


Leu Arg Ala Gly Pro Cys Ser Leu Ser Gln Gly Asn Leu Ser Pro Asn 
                565                 570                 575     


Trp Pro Arg Trp Gln Gly Ser Pro Ala Glu Leu Asp Ser Asp Thr Gln 
            580                 585                 590         


Gly Ala Arg Arg Thr Gln Ala Ala Ala Pro Ala Thr Glu Gly Arg Ala 
        595                 600                 605             


His Pro Ala Val Ser Arg Ala Cys Ser Thr Pro His Val Gln Val Ala 
    610                 615                 620                 


Gly Lys Ala Glu Arg Pro Thr Ala Arg Ser Glu Gln Tyr Leu Thr Leu 
625                 630                 635                 640 


Ser Gly Ala His Asp Leu Ser Glu Ser Glu Leu Asp Val Ala Gly Leu 
                645                 650                 655     


Gln Ser Arg Ala Thr Pro Gln Cys Gln Arg Pro His Gly Ser Gly Arg 
            660                 665                 670         


Asp Asp Lys Arg Pro Pro Pro Pro Tyr Pro Gly Pro Gly Lys Pro Ala 
        675                 680                 685             


Ala Ala Ala Ala Trp Ile Gln Gly Pro Pro Glu Gly Val Glu Thr Pro 
    690                 695                 700                 


Thr Asp Gln Gly Gly Gln Ala Ala Glu Arg Glu Gln Gln Val Thr Gln 
705                 710                 715                 720 


Lys Lys Leu Ser Ser Ala Asn Ser Leu Pro Ala Gly Glu Gln Asp Ser 
                725                 730                 735     


Pro Arg Leu Gly Asp Ala Gly Trp Leu Asp Trp Gln Arg Glu Arg Trp 
            740                 745                 750         


Gln Ile Trp Glu Leu Leu Ser Thr Asp Asn Pro Asp Ala Leu Pro Glu 
        755                 760                 765             


Thr Leu Val 
    770     


<210>  1048
<211>  771
<212>  PRT
<213>  Homo Sapiens

<400>  1048

Met Ser Gly Arg Ser Val Arg Leu Arg Ser Val Pro Ile Gln Ser Leu 
1               5                   10                  15      


Ser Glu Leu Glu Arg Ala Arg Leu Gln Glu Val Ala Phe Tyr Gln Leu 
            20                  25                  30          


Gln Gln Asp Cys Asp Leu Ser Cys Gln Ile Thr Ile Pro Lys Asp Gly 
        35                  40                  45              


Gln Lys Arg Lys Lys Ser Leu Arg Lys Lys Leu Asp Ser Leu Gly Lys 
    50                  55                  60                  


Glu Lys Asn Lys Asp Lys Glu Phe Ile Pro Gln Ala Phe Gly Met Pro 
65                  70                  75                  80  


Leu Ser Gln Val Ile Ala Asn Asp Arg Ala Tyr Lys Leu Lys Gln Asp 
                85                  90                  95      


Leu Gln Arg Asp Glu Gln Lys Asp Ala Ser Asp Phe Val Ala Ser Leu 
            100                 105                 110         


Leu Pro Phe Gly Asn Lys Arg Gln Asn Lys Glu Leu Ser Ser Ser Asn 
        115                 120                 125             


Ser Ser Leu Ser Ser Thr Ser Glu Thr Pro Asn Glu Ser Thr Ser Pro 
    130                 135                 140                 


Asn Thr Pro Glu Pro Ala Pro Arg Ala Arg Arg Arg Gly Ala Met Ser 
145                 150                 155                 160 


Val Asp Ser Ile Thr Asp Leu Asp Asp Asn Gln Ser Arg Leu Leu Glu 
                165                 170                 175     


Ala Leu Gln Leu Ser Leu Pro Ala Glu Ala Gln Ser Lys Lys Glu Lys 
            180                 185                 190         


Ala Arg Asp Lys Lys Leu Ser Leu Asn Pro Ile Tyr Arg Gln Val Pro 
        195                 200                 205             


Arg Leu Val Asp Ser Cys Cys Gln His Leu Glu Lys His Gly Leu Gln 
    210                 215                 220                 


Thr Val Gly Ile Phe Arg Val Gly Ser Ser Lys Lys Arg Val Arg Gln 
225                 230                 235                 240 


Leu Arg Glu Glu Phe Asp Arg Gly Ile Asp Val Ser Leu Glu Glu Glu 
                245                 250                 255     


His Ser Val His Asp Val Ala Ala Leu Leu Lys Glu Phe Leu Arg Asp 
            260                 265                 270         


Met Pro Asp Pro Leu Leu Thr Arg Glu Leu Tyr Thr Ala Phe Ile Asn 
        275                 280                 285             


Thr Leu Leu Leu Glu Pro Glu Glu Gln Leu Gly Thr Leu Gln Leu Leu 
    290                 295                 300                 


Ile Tyr Leu Leu Pro Pro Cys Asn Cys Asp Thr Leu His Arg Leu Leu 
305                 310                 315                 320 


Gln Phe Leu Ser Ile Val Ala Arg His Ala Asp Asp Asn Ile Ser Lys 
                325                 330                 335     


Asp Gly Gln Glu Val Thr Gly Asn Lys Met Thr Ser Leu Asn Leu Ala 
            340                 345                 350         


Thr Ile Phe Gly Pro Asn Leu Leu His Lys Gln Lys Ser Ser Asp Lys 
        355                 360                 365             


Glu Phe Ser Val Gln Ser Ser Ala Arg Ala Glu Glu Ser Thr Ala Ile 
    370                 375                 380                 


Ile Ala Val Val Gln Lys Met Ile Glu Asn Tyr Glu Ala Leu Phe Met 
385                 390                 395                 400 


Val Pro Pro Asp Leu Gln Asn Glu Val Leu Ile Ser Leu Leu Glu Thr 
                405                 410                 415     


Asp Pro Asp Val Val Asp Tyr Leu Leu Arg Arg Lys Ala Ser Gln Ser 
            420                 425                 430         


Ser Ser Pro Asp Met Leu Gln Ser Glu Val Ser Phe Ser Val Gly Gly 
        435                 440                 445             


Arg His Ser Ser Thr Asp Ser Asn Lys Ala Ser Ser Gly Asp Ile Ser 
    450                 455                 460                 


Pro Tyr Asp Asn Asn Ser Pro Val Leu Ser Glu Arg Ser Leu Leu Ala 
465                 470                 475                 480 


Met Gln Glu Asp Ala Ala Pro Gly Gly Ser Glu Lys Leu Tyr Arg Val 
                485                 490                 495     


Pro Gly Gln Phe Met Leu Val Gly His Leu Ser Ser Ser Lys Ser Arg 
            500                 505                 510         


Glu Ser Ser Pro Gly Pro Arg Leu Gly Lys Asp Leu Ser Glu Glu Pro 
        515                 520                 525             


Phe Asp Ile Trp Gly Thr Trp His Ser Thr Leu Lys Ser Gly Ser Lys 
    530                 535                 540                 


Asp Pro Gly Met Thr Gly Ser Ser Gly Asp Ile Phe Glu Ser Ser Ser 
545                 550                 555                 560 


Leu Arg Ala Gly Pro Cys Ser Leu Ser Gln Gly Asn Leu Ser Pro Asn 
                565                 570                 575     


Trp Pro Arg Trp Gln Gly Ser Pro Ala Glu Leu Asp Ser Asp Thr Gln 
            580                 585                 590         


Gly Ala Arg Arg Thr Gln Ala Ala Ala Pro Ala Thr Glu Gly Arg Ala 
        595                 600                 605             


His Pro Ala Val Ser Arg Ala Cys Ser Thr Pro His Val Gln Val Ala 
    610                 615                 620                 


Gly Lys Ala Glu Arg Pro Thr Ala Arg Ser Glu Gln Tyr Leu Thr Leu 
625                 630                 635                 640 


Ser Gly Ala His Asp Leu Ser Glu Ser Glu Leu Asp Val Ala Gly Leu 
                645                 650                 655     


Gln Ser Arg Ala Thr Pro Gln Cys Gln Arg Pro His Gly Ser Gly Arg 
            660                 665                 670         


Asp Asp Lys Arg Pro Pro Pro Pro Tyr Pro Gly Pro Gly Lys Pro Ala 
        675                 680                 685             


Ala Ala Ala Ala Trp Ile Gln Gly Pro Pro Glu Gly Val Glu Thr Pro 
    690                 695                 700                 


Thr Asp Gln Gly Gly Gln Ala Ala Glu Arg Glu Gln Gln Val Thr Gln 
705                 710                 715                 720 


Lys Lys Leu Ser Ser Ala Asn Ser Leu Pro Ala Gly Glu Gln Asp Ser 
                725                 730                 735     


Pro Arg Leu Gly Asp Ala Gly Trp Leu Asp Trp Gln Arg Glu Arg Trp 
            740                 745                 750         


Gln Ile Trp Glu Leu Leu Ser Thr Asp Asn Pro Asp Ala Leu Pro Glu 
        755                 760                 765             


Thr Leu Val 
    770     


<210>  1049
<211>  1816
<212>  PRT
<213>  Homo Sapiens

<400>  1049

Met Leu Ser Val Val His Phe Leu Arg Ser Phe Phe Lys Thr Pro Glu 
1               5                   10                  15      


Pro Gly Ala His Leu Pro Gly Glu Gly Glu Ile Glu Asp Asn Gln Leu 
            20                  25                  30          


Pro Thr Ser Pro Ala Glu Gln Val Glu Gln Gly Trp Asn Gln Gln Thr 
        35                  40                  45              


Asp Arg Asp Asp Ser Glu Thr Leu Ser Gln Gln Ser Glu Ser Gly Ser 
    50                  55                  60                  


Asp Thr Lys Thr Asp Pro Phe Glu Ser Ala Ser Asp Thr Glu Ser Leu 
65                  70                  75                  80  


Ser Gly Tyr Leu Pro Arg Gly Val Phe His Pro Leu Arg Gly Thr Pro 
                85                  90                  95      


Val Asp Ile Glu Ala Pro Trp Glu Tyr Pro Asp Val Ser Ala Thr Gly 
            100                 105                 110         


Pro Pro Gln Glu Gln His Leu Thr Ser Val Pro Gly Leu His Ala Lys 
        115                 120                 125             


Glu Glu Leu Asp Leu Ser Pro Ser Leu Glu Asp Asp Ser Cys Lys Asn 
    130                 135                 140                 


Gly Trp Arg Ala Phe Ala Thr Val Ala Gly Glu Gln Glu Ala Gly His 
145                 150                 155                 160 


Leu Trp Asp Cys Ala Thr Ser Leu Glu Arg Glu Ser Leu Leu Ala Gly 
                165                 170                 175     


Val Pro Arg His Thr Gly Cys Cys Leu Gln Arg Ala Thr Asp Ser Ser 
            180                 185                 190         


Gly Pro Glu Pro Val Gln Gly Val Ala Val Gln Asp Leu Arg Gly Leu 
        195                 200                 205             


Ser Ser Val Ser Leu Gln Lys Ser Arg Ser Glu Ser Tyr Leu Gly Ile 
    210                 215                 220                 


Pro Val Val Trp Pro Phe Leu Leu Trp Cys Cys Glu Leu Gly Arg Ser 
225                 230                 235                 240 


Trp Pro His Ile His Asn Arg Ala Arg Ala Leu Val Leu Pro Ser Arg 
                245                 250                 255     


Gly Pro Leu Asp Asn Thr Ala Pro Leu Gly Thr Arg Thr Lys Lys Glu 
            260                 265                 270         


Ser Thr Leu Gly Pro Ala Gly Asp Thr Glu Leu Leu Trp Ser Gln Pro 
        275                 280                 285             


His Ser Asp Val Pro Cys Gln Pro Pro Leu Arg Thr Ser Cys Leu Leu 
    290                 295                 300                 


Arg Thr Asn Arg His His Ser Ala Pro Glu Thr Thr Gly Asp Lys Asn 
305                 310                 315                 320 


Arg Ala Ser Pro Arg Leu Asn Cys Gly His Met Arg Ala Leu Val Arg 
                325                 330                 335     


Ala His Ser Ile Ala Gly Phe Ser Pro Glu Cys Pro Glu Asp Pro Val 
            340                 345                 350         


Gly Gln Asn Val Val Lys Ser Gly Thr His Val Lys Glu Gly Ala Lys 
        355                 360                 365             


Asn Glu Arg Asp Pro Arg Ile Gln Asn Ile Pro Ser Pro Ala Pro Thr 
    370                 375                 380                 


Gln Leu Ser Gly Pro Ile Pro Ala Phe Gln Ser Gly Ala Pro His Leu 
385                 390                 395                 400 


Gln Gly Pro Cys Lys Pro Gly Gly Phe Arg Leu Gln Arg Ala Ser Gln 
                405                 410                 415     


Asp Thr Pro Ser Ala Gly Leu Leu Gly Glu Asn Gln Leu Arg Gln Asp 
            420                 425                 430         


Ser Arg Ser Cys Leu Val Ala Ser Cys Leu Thr Ser Glu Leu Val Lys 
        435                 440                 445             


Leu Ser Ala Glu Glu Val Pro Glu Pro Ala Glu Cys Lys Ser Glu Gln 
    450                 455                 460                 


Ser Pro Glu Ser Arg Thr Gln Glu Pro Gln Gly Thr Gln Leu Ala Pro 
465                 470                 475                 480 


Arg Ala Ala Asp Glu Arg Glu Thr Gln Lys His Leu Trp Gly Ile Ser 
                485                 490                 495     


Val Gln Ala Gly Asn Gln Thr Ser Asn Tyr Thr Ser Lys Tyr Val Leu 
            500                 505                 510         


Ser Glu Glu Ser Lys Ser Pro Thr Arg Ala Lys Phe Pro Arg Gln Pro 
        515                 520                 525             


Ser Ser Glu Gly Thr Gln Val Trp Ser Gly Asp Leu Met Gly Cys Leu 
    530                 535                 540                 


Glu Val Ser Asp Ser Ser Asp Ala Pro Glu Thr Thr Gln Lys Ser Ser 
545                 550                 555                 560 


Ala Ile Asp Thr Ser Lys Ala Ala Glu Glu Ala Met Val Leu Asp Pro 
                565                 570                 575     


Asn Tyr Arg Glu Gln Ala Leu Gln Gly Leu Ser Glu Phe Lys Ala Ala 
            580                 585                 590         


Thr Val Ser His Cys Gly Pro Gly Ala Glu Glu Gly Glu Gln Gly Pro 
        595                 600                 605             


Gly Gly Ala Gly Gly Arg Gln Leu Glu Pro Lys Ala Gly Gly Glu Ala 
    610                 615                 620                 


Ser Arg Gly Arg Gly Ala Leu Ile Ile Val Ala Val Glu Gln Lys Gly 
625                 630                 635                 640 


Leu Gln Ala Ser Arg Ser Asn Ala Gly Pro Val Pro Glu Thr Leu Pro 
                645                 650                 655     


Arg Asp Phe Pro Lys Glu Arg Pro Glu Ser Pro Leu Ser Thr Gly Glu 
            660                 665                 670         


Thr Pro Cys Glu Ser Pro Thr Arg Gly Lys Thr Pro Ala Gly Asn Glu 
        675                 680                 685             


Cys Glu Leu Pro Ala Ala Pro Ile Gln Gly Ala Gly Asp Gly Ala Leu 
    690                 695                 700                 


Gln Arg Val Ala Gln Ala Ala Glu Leu Gly Arg Val Leu Val Pro Gln 
705                 710                 715                 720 


Ala Ala Ser Glu Glu Thr Pro Ser Thr Glu Glu Pro Pro Gly Glu Arg 
                725                 730                 735     


Leu Arg Gly Glu Ser Arg Ser Ser Gly Ser Gly Glu Arg Gly Pro Glu 
            740                 745                 750         


Glu Ala Pro Glu Gly Gly Ala Ala Ala Ala Arg Gly Gln Arg Pro Arg 
        755                 760                 765             


Val Pro Ala Leu Glu Pro Pro Gln Pro Pro Arg Gly Leu Arg Lys Gly 
    770                 775                 780                 


Ala Gln Glu Pro Gly Lys Arg Pro Thr Phe Ser Lys Val Thr Ser Phe 
785                 790                 795                 800 


Arg Lys Gly Arg Pro Leu Ala Thr Glu Ser Pro Gly Gly Val Pro Ala 
                805                 810                 815     


Pro Thr Thr Glu Gly Arg Arg Trp Gly Ser Ser Gly Pro Glu Gly Leu 
            820                 825                 830         


Pro Arg Glu Asn Pro Pro Ala Ala Ala Gly Arg Asp Ala Pro Pro Leu 
        835                 840                 845             


His His Gly Asp Ala Ser Ala Trp Pro Glu Phe Val Pro Gln Ala Ala 
    850                 855                 860                 


Gly Asp Arg Thr Ala Gly Pro Ala Gly Ala Gly His Thr Gly Thr Ser 
865                 870                 875                 880 


Gly Asp Leu Gly Ser Arg Gly Pro Ser Ser Glu Ser Cys Asn Ala Lys 
                885                 890                 895     


Arg Leu Lys Thr Thr Glu Lys Lys Leu Arg Ala Arg Leu Ala Leu Ala 
            900                 905                 910         


His Lys Thr Phe Ser Asn Phe Ile Glu Ser Ile Val Leu Glu Lys Glu 
        915                 920                 925             


Asn Thr His Glu Arg Ser Pro Ser Ser Pro Lys Gly Glu Lys Glu Lys 
    930                 935                 940                 


Ser Arg Leu Arg Gln Gly Ser Trp Arg Ala Phe Leu Lys Ser Lys Asp 
945                 950                 955                 960 


Ala Gly Ser Pro Lys Lys Pro Thr Leu Val Ser Leu Pro Leu Gly Pro 
                965                 970                 975     


Glu Val Leu Ser Pro Ala Glu Thr Asp Ser His Cys Glu Glu Arg Ala 
            980                 985                 990         


Glu Asp Lys Glu Gly Tyr Val Phe  Ser Asp His Trp Ala  Pro Pro Leu 
        995                 1000                 1005             


Ala Ser  Thr Pro Leu Ser Ser  Ser Leu Val Ser Pro  Glu His Arg 
    1010                 1015                 1020             


Arg Lys  Ser Glu Pro Thr Ile  Lys Cys Thr Ala Thr  Gln Glu Gly 
    1025                 1030                 1035             


Gly Arg  Tyr Leu Pro Ser Gly  Ile Phe Pro Glu Lys  Ser Trp Leu 
    1040                 1045                 1050             


Ala Ser  Pro Gly Ser Pro Arg  Ala Gln Gln Ala Gly  Ile Ala His 
    1055                 1060                 1065             


Thr Leu  Pro Ser Ser Ser Ala  Cys Cys Leu Ala Tyr  Glu Asn Pro 
    1070                 1075                 1080             


Gly Thr  Pro Cys Arg Pro Thr  Ser Pro Lys Pro Leu  Ser Pro Arg 
    1085                 1090                 1095             


Pro Ser  Ala Gln Arg Met Gly  Leu His Tyr Pro Gly  Arg Gly Ser 
    1100                 1105                 1110             


Ala Ile  Ser Met Val Ser Leu  Gly Ser Tyr Ser Tyr  Val Asp Ser 
    1115                 1120                 1125             


Ser Ser  Gly Asp Pro Glu Arg  Pro Lys Ile Pro Lys  Gly Gln Thr 
    1130                 1135                 1140             


Ser Phe  Leu Leu Ser Leu Gln  Thr Leu Asn Gln Asp  Glu Gln Lys 
    1145                 1150                 1155             


Glu Glu  Ser Arg Glu Gly Gly  Gln Gly Pro Arg Gly  Leu Gly Thr 
    1160                 1165                 1170             


Val Pro  Trp Leu Arg Asp Leu  Pro Gly Ser Glu Asn  His Met Pro 
    1175                 1180                 1185             


Trp Glu  Glu Pro Ala Gly Glu  Lys Pro Ser Cys Ser  His Ser Gln 
    1190                 1195                 1200             


Lys Ala  Phe His Met Glu Pro  Ala Gln Lys Pro Cys  Phe Thr Thr 
    1205                 1210                 1215             


Asp Met  Val Thr Trp Ala Leu  Leu Cys Ile Ser Ala  Glu Thr Val 
    1220                 1225                 1230             


Arg Gly  Glu Ala Pro Ser Gln  Pro Arg Gly Ile Pro  His Arg Ser 
    1235                 1240                 1245             


Pro Val  Ser Val Asp Asp Leu  Trp Leu Glu Lys Thr  Gln Arg Lys 
    1250                 1255                 1260             


Lys Leu  Gln Lys Gln Ala His  Val Glu Arg Arg Leu  His Ile Gly 
    1265                 1270                 1275             


Ala Val  His Lys Asp Gly Val  Lys Cys Trp Arg Lys  Thr Ile Ile 
    1280                 1285                 1290             


Thr Ser  Pro Glu Ser Leu Asn  Leu Pro Arg Arg Ser  His Pro Leu 
    1295                 1300                 1305             


Ser Gln  Ser Ala Pro Thr Gly  Leu Asn His Met Gly  Trp Pro Glu 
    1310                 1315                 1320             


His Thr  Pro Gly Thr Ala Met  Pro Asp Gly Ala Leu  Asp Thr Ala 
    1325                 1330                 1335             


Val Cys  Ala Asp Glu Val Gly  Ser Glu Glu Asp Leu  Tyr Asp Asp 
    1340                 1345                 1350             


Leu His  Ser Ser Ser His His  Tyr Ser His Pro Gly  Gly Gly Gly 
    1355                 1360                 1365             


Glu Gln  Leu Ala Ile Asn Glu  Leu Ile Ser Asp Gly  Ser Val Val 
    1370                 1375                 1380             


Cys Ala  Glu Ala Leu Trp Asp  His Val Thr Met Asp  Asp Gln Glu 
    1385                 1390                 1395             


Leu Gly  Phe Lys Ala Gly Asp  Val Ile Glu Val Met  Asp Ala Thr 
    1400                 1405                 1410             


Asn Arg  Glu Trp Trp Trp Gly  Arg Val Ala Asp Gly  Glu Gly Trp 
    1415                 1420                 1425             


Phe Pro  Ala Ser Phe Val Arg  Leu Arg Val Asn Gln  Asp Glu Pro 
    1430                 1435                 1440             


Ala Asp  Asp Asp Ala Pro Leu  Ala Gly Asn Ser Gly  Ala Glu Asp 
    1445                 1450                 1455             


Gly Gly  Ala Glu Ala Gln Ser  Ser Lys Asp Gln Met  Arg Thr Asn 
    1460                 1465                 1470             


Val Ile  Asn Glu Ile Leu Ser  Thr Glu Arg Asp Tyr  Ile Lys His 
    1475                 1480                 1485             


Leu Arg  Asp Ile Cys Glu Gln  Ala Asp Phe Gln Ile  Tyr Ser Glu 
    1490                 1495                 1500             


Tyr Cys  Asn Asn His Pro Asn  Ala Cys Val Glu Leu  Ser Arg Leu 
    1505                 1510                 1515             


Thr Lys  Leu Ser Lys Tyr Val  Tyr Phe Phe Glu Ala  Cys Arg Leu 
    1520                 1525                 1530             


Leu Gln  Lys Met Ile Asp Ile  Ser Leu Asp Gly Phe  Leu Leu Thr 
    1535                 1540                 1545             


Pro Val  Gln Lys Ile Cys Lys  Tyr Pro Leu Gln Leu  Ala Glu Leu 
    1550                 1555                 1560             


Leu Lys  Tyr Thr His Pro Gln  His Arg Asp Phe Lys  Asp Val Glu 
    1565                 1570                 1575             


Ala Ala  Leu His Ala Met Lys  Asn Val Ala Gln Leu  Ile Asn Glu 
    1580                 1585                 1590             


Arg Lys  Arg Arg Leu Glu Asn  Ile Asp Lys Ile Ala  Gln Trp Gln 
    1595                 1600                 1605             


Ser Ser  Ile Glu Asp Trp Glu  Gly Glu Asp Leu Leu  Val Arg Ser 
    1610                 1615                 1620             


Ser Glu  Leu Ile Tyr Ser Gly  Glu Leu Thr Arg Val  Thr Gln Pro 
    1625                 1630                 1635             


Gln Ala  Lys Ser Gln Gln Arg  Met Phe Phe Leu Phe  Asp His Gln 
    1640                 1645                 1650             


Leu Ile  Tyr Cys Lys Lys Asp  Leu Leu Arg Arg Asp  Val Leu Tyr 
    1655                 1660                 1665             


Tyr Lys  Gly Arg Leu Asp Met  Asp Gly Leu Glu Val  Val Asp Leu 
    1670                 1675                 1680             


Glu Asp  Gly Lys Asp Arg Asp  Leu His Val Ser Ile  Lys Asn Ala 
    1685                 1690                 1695             


Phe Arg  Leu His Arg Gly Ala  Thr Gly Asp Ser His  Leu Leu Cys 
    1700                 1705                 1710             


Thr Arg  Lys Pro Glu Gln Lys  Gln Arg Trp Leu Lys  Ala Phe Ala 
    1715                 1720                 1725             


Arg Glu  Arg Glu Gln Val Gln  Leu Asp Gln Glu Thr  Gly Phe Ser 
    1730                 1735                 1740             


Ile Thr  Glu Leu Gln Arg Lys  Gln Ala Met Leu Asn  Ala Ser Lys 
    1745                 1750                 1755             


Gln Gln  Val Thr Gly Lys Pro  Lys Ala Val Gly Arg  Pro Cys Tyr 
    1760                 1765                 1770             


Leu Thr  Arg Gln Lys His Pro  Ala Leu Pro Ser Asn  Arg Pro Gln 
    1775                 1780                 1785             


Gln Gln  Val Leu Val Leu Ala  Glu Pro Arg Arg Lys  Pro Ser Thr 
    1790                 1795                 1800             


Phe Trp  His Ser Ile Ser Arg  Leu Ala Pro Phe Arg  Lys 
    1805                 1810                 1815     


<210>  1050
<211>  690
<212>  PRT
<213>  Homo Sapiens

<400>  1050

Met Pro Trp Glu Glu Pro Ala Gly Glu Lys Pro Ser Cys Ser His Ser 
1               5                   10                  15      


Gln Lys Ala Phe His Met Glu Pro Ala Gln Lys Pro Cys Phe Thr Thr 
            20                  25                  30          


Asp Met Val Thr Trp Ala Leu Leu Cys Ile Ser Ala Glu Thr Val Arg 
        35                  40                  45              


Gly Glu Ala Pro Ser Gln Pro Arg Gly Ile Pro His Arg Ser Pro Val 
    50                  55                  60                  


Ser Val Asp Asp Leu Trp Leu Glu Lys Thr Gln Arg Lys Lys Leu Gln 
65                  70                  75                  80  


Lys Gln Ala His Val Glu Arg Arg Leu His Ile Gly Ala Val His Lys 
                85                  90                  95      


Asp Gly Val Lys Cys Trp Arg Lys Thr Ile Ile Thr Ser Pro Glu Ser 
            100                 105                 110         


Leu Asn Leu Pro Arg Arg Ser His Pro Leu Ser Gln Ser Ala Pro Thr 
        115                 120                 125             


Gly Leu Asn His Met Gly Trp Pro Glu His Thr Pro Gly Thr Ala Met 
    130                 135                 140                 


Pro Asp Gly Ala Leu Asp Thr Ala Val Cys Ala Asp Glu Val Gly Ser 
145                 150                 155                 160 


Glu Glu Asp Leu Tyr Asp Asp Leu His Ser Ser Ser His His Tyr Ser 
                165                 170                 175     


His Pro Gly Gly Gly Gly Glu Gln Leu Ala Ile Asn Glu Leu Ile Ser 
            180                 185                 190         


Asp Gly Ser Val Val Cys Ala Glu Ala Leu Trp Asp His Val Thr Met 
        195                 200                 205             


Asp Asp Gln Glu Leu Gly Phe Lys Ala Gly Asp Val Ile Glu Val Met 
    210                 215                 220                 


Asp Ala Thr Asn Arg Glu Trp Trp Trp Gly Arg Val Ala Asp Gly Glu 
225                 230                 235                 240 


Gly Trp Phe Pro Ala Ser Phe Val Arg Leu Arg Val Asn Gln Asp Glu 
                245                 250                 255     


Pro Ala Asp Asp Asp Ala Pro Leu Ala Gly Asn Ser Gly Ala Glu Asp 
            260                 265                 270         


Gly Gly Ala Glu Ala Gln Ser Ser Lys Asp Gln Met Arg Thr Asn Val 
        275                 280                 285             


Ile Asn Glu Ile Leu Ser Thr Glu Arg Asp Tyr Ile Lys His Leu Arg 
    290                 295                 300                 


Asp Ile Cys Glu Gly Tyr Val Arg Gln Cys Arg Lys Arg Ala Asp Met 
305                 310                 315                 320 


Phe Ser Glu Glu Gln Leu Arg Thr Ile Phe Gly Asn Ile Glu Asp Ile 
                325                 330                 335     


Tyr Arg Cys Gln Lys Ala Phe Val Lys Ala Leu Glu Gln Arg Phe Asn 
            340                 345                 350         


Arg Glu Arg Pro His Leu Ser Glu Leu Gly Ala Cys Phe Leu Glu His 
        355                 360                 365             


Gln Ala Asp Phe Gln Ile Tyr Ser Glu Tyr Cys Asn Asn His Pro Asn 
    370                 375                 380                 


Ala Cys Val Glu Leu Ser Arg Leu Thr Lys Leu Ser Lys Tyr Val Tyr 
385                 390                 395                 400 


Phe Phe Glu Ala Cys Arg Leu Leu Gln Lys Met Ile Asp Ile Ser Leu 
                405                 410                 415     


Asp Gly Phe Leu Leu Thr Pro Val Gln Lys Ile Cys Lys Tyr Pro Leu 
            420                 425                 430         


Gln Leu Ala Glu Leu Leu Lys Tyr Thr His Pro Gln His Arg Asp Phe 
        435                 440                 445             


Lys Asp Val Glu Ala Ala Leu His Ala Met Lys Asn Val Ala Gln Leu 
    450                 455                 460                 


Ile Asn Glu Arg Lys Arg Arg Leu Glu Asn Ile Asp Lys Ile Ala Gln 
465                 470                 475                 480 


Trp Gln Ser Ser Ile Glu Asp Trp Glu Gly Glu Asp Leu Leu Val Arg 
                485                 490                 495     


Ser Ser Glu Leu Ile Tyr Ser Gly Glu Leu Thr Arg Val Thr Gln Pro 
            500                 505                 510         


Gln Ala Lys Ser Gln Gln Arg Met Phe Phe Leu Phe Asp His Gln Leu 
        515                 520                 525             


Ile Tyr Cys Lys Lys Asp Leu Leu Arg Arg Asp Val Leu Tyr Tyr Lys 
    530                 535                 540                 


Gly Arg Leu Asp Met Asp Gly Leu Glu Val Val Asp Leu Glu Asp Gly 
545                 550                 555                 560 


Lys Asp Arg Asp Leu His Val Ser Ile Lys Asn Ala Phe Arg Leu His 
                565                 570                 575     


Arg Gly Ala Thr Gly Asp Ser His Leu Leu Cys Thr Arg Lys Pro Glu 
            580                 585                 590         


Gln Lys Gln Arg Trp Leu Lys Ala Phe Ala Arg Glu Arg Glu Gln Val 
        595                 600                 605             


Gln Leu Asp Gln Glu Thr Gly Phe Ser Ile Thr Glu Leu Gln Arg Lys 
    610                 615                 620                 


Gln Ala Met Leu Asn Ala Ser Lys Gln Gln Val Thr Gly Lys Pro Lys 
625                 630                 635                 640 


Ala Val Gly Arg Pro Cys Tyr Leu Thr Arg Gln Lys His Pro Ala Leu 
                645                 650                 655     


Pro Ser Asn Arg Pro Gln Gln Gln Val Leu Val Leu Ala Glu Pro Arg 
            660                 665                 670         


Arg Lys Pro Ser Thr Phe Trp His Ser Ile Ser Arg Leu Ala Pro Phe 
        675                 680                 685             


Arg Lys 
    690 


<210>  1051
<211>  670
<212>  PRT
<213>  Homo Sapiens

<400>  1051

Met Pro Trp Glu Glu Pro Ala Gly Glu Lys Pro Ser Cys Ser His Ser 
1               5                   10                  15      


Gln Lys Ala Phe His Met Glu Pro Ala Gln Lys Pro Cys Phe Thr Thr 
            20                  25                  30          


Asp Met Val Thr Trp Ala Leu Leu Cys Ile Ser Ala Glu Thr Val Arg 
        35                  40                  45              


Gly Glu Ala Pro Ser Gln Pro Arg Gly Ile Pro His Arg Ser Pro Val 
    50                  55                  60                  


Ser Val Asp Asp Leu Trp Leu Glu Lys Thr Gln Arg Lys Lys Leu Gln 
65                  70                  75                  80  


Lys Gln Ala His Val Glu Arg Arg Leu His Ile Gly Ala Val His Lys 
                85                  90                  95      


Asp Gly Val Lys Cys Trp Arg Lys Thr Ile Ile Thr Ser Pro Glu Ser 
            100                 105                 110         


Leu Asn Leu Pro Arg Arg Ser His Pro Leu Ser Gln Ser Ala Pro Thr 
        115                 120                 125             


Gly Leu Asn His Met Gly Trp Pro Glu His Thr Pro Gly Thr Ala Met 
    130                 135                 140                 


Pro Asp Gly Ala Leu Asp Thr Ala Val Cys Ala Asp Glu Val Gly Ser 
145                 150                 155                 160 


Glu Glu Asp Leu Tyr Asp Asp Leu His Ser Ser Ser His His Tyr Ser 
                165                 170                 175     


His Pro Gly Gly Gly Gly Glu Gln Leu Ala Ile Asn Glu Leu Ile Ser 
            180                 185                 190         


Asp Gly Ser Val Val Cys Ala Glu Ala Leu Trp Asp His Val Thr Met 
        195                 200                 205             


Asp Asp Gln Glu Leu Gly Phe Lys Ala Gly Asp Val Ile Glu Val Met 
    210                 215                 220                 


Asp Ala Thr Asn Arg Glu Trp Trp Trp Gly Arg Val Ala Asp Gly Glu 
225                 230                 235                 240 


Gly Trp Phe Pro Ala Ser Phe Val Arg Leu Arg Val Asn Gln Asp Glu 
                245                 250                 255     


Pro Ala Asp Asp Asp Ala Pro Leu Ala Gly Asn Ser Gly Ala Glu Asp 
            260                 265                 270         


Gly Gly Ala Glu Ala Gln Ser Ser Lys Asp Gln Met Arg Thr Asn Val 
        275                 280                 285             


Ile Asn Glu Ile Leu Ser Thr Glu Arg Asp Tyr Ile Lys His Leu Arg 
    290                 295                 300                 


Asp Ile Cys Glu Gly Tyr Val Arg Gln Cys Arg Lys Arg Ala Asp Met 
305                 310                 315                 320 


Phe Ser Glu Glu Gln Leu Arg Thr Ile Phe Gly Asn Ile Glu Asp Ile 
                325                 330                 335     


Tyr Arg Cys Gln Lys Ala Phe Val Lys Ala Leu Glu Gln Arg Phe Asn 
            340                 345                 350         


Arg Glu Arg Pro His Leu Ser Glu Leu Gly Ala Cys Phe Leu Glu His 
        355                 360                 365             


Gln Ala Asp Phe Gln Ile Tyr Ser Glu Tyr Cys Asn Asn His Pro Asn 
    370                 375                 380                 


Ala Cys Val Glu Leu Ser Arg Leu Thr Lys Leu Ser Lys Tyr Val Tyr 
385                 390                 395                 400 


Phe Phe Glu Ala Cys Arg Leu Leu Gln Lys Met Ile Asp Ile Ser Leu 
                405                 410                 415     


Asp Gly Phe Leu Leu Thr Pro Val Gln Lys Ile Cys Lys Tyr Pro Leu 
            420                 425                 430         


Gln Leu Ala Glu Leu Leu Lys Tyr Thr His Pro Gln His Arg Asp Phe 
        435                 440                 445             


Lys Asp Val Glu Ala Ala Leu His Ala Met Lys Asn Val Ala Gln Leu 
    450                 455                 460                 


Ile Asn Glu Arg Lys Arg Arg Leu Glu Asn Ile Asp Lys Ile Ala Gln 
465                 470                 475                 480 


Trp Gln Ser Ser Ile Glu Asp Trp Glu Gly Glu Asp Leu Leu Val Arg 
                485                 490                 495     


Ser Ser Glu Leu Ile Tyr Ser Gly Glu Leu Thr Arg Val Thr Gln Pro 
            500                 505                 510         


Gln Ala Lys Ser Gln Gln Arg Met Phe Phe Leu Phe Asp His Gln Leu 
        515                 520                 525             


Ile Tyr Cys Lys Lys Asp Leu Leu Arg Arg Asp Val Leu Tyr Tyr Lys 
    530                 535                 540                 


Gly Arg Leu Asp Met Asp Gly Leu Glu Val Val Asp Leu Glu Asp Gly 
545                 550                 555                 560 


Lys Asp Arg Asp Leu His Val Ser Ile Lys Asn Ala Phe Arg Leu His 
                565                 570                 575     


Arg Gly Ala Thr Gly Asp Ser His Leu Leu Cys Thr Arg Lys Pro Glu 
            580                 585                 590         


Gln Lys Gln Arg Trp Leu Lys Ala Phe Ala Arg Glu Arg Glu Gln Val 
        595                 600                 605             


Gln Leu Asp Gln Glu Thr Gly Phe Ser Ile Thr Glu Leu Gln Arg Lys 
    610                 615                 620                 


Gln Ala Met Leu Asn Ala Ser Lys Gln Gln Val Thr Gly Lys Pro Lys 
625                 630                 635                 640 


Gly Arg Arg Thr Ala Ala Pro Pro Pro Arg Leu Pro Gly Pro Tyr Pro 
                645                 650                 655     


Ala Asp Ile Ile Pro Phe Ser Glu Pro Gln Ser Gln Ala Ser 
            660                 665                 670 


<210>  1052
<211>  630
<212>  PRT
<213>  Homo Sapiens

<400>  1052

Met Pro Trp Glu Glu Pro Ala Gly Glu Lys Pro Ser Cys Ser His Ser 
1               5                   10                  15      


Gln Lys Ala Phe His Met Glu Pro Ala Gln Lys Pro Cys Phe Thr Thr 
            20                  25                  30          


Asp Met Val Thr Trp Ala Leu Leu Cys Ile Ser Ala Glu Thr Val Arg 
        35                  40                  45              


Gly Glu Ala Pro Ser Gln Pro Arg Gly Ile Pro His Arg Ser Pro Val 
    50                  55                  60                  


Ser Val Asp Asp Leu Trp Leu Glu Lys Thr Gln Arg Lys Lys Leu Gln 
65                  70                  75                  80  


Lys Gln Ala His Val Glu Arg Arg Leu His Ile Gly Ala Val His Lys 
                85                  90                  95      


Asp Gly Val Lys Cys Trp Arg Lys Thr Ile Ile Thr Ser Pro Glu Ser 
            100                 105                 110         


Leu Asn Leu Pro Arg Arg Ser His Pro Leu Ser Gln Ser Ala Pro Thr 
        115                 120                 125             


Gly Leu Asn His Met Gly Trp Pro Glu His Thr Pro Gly Thr Ala Met 
    130                 135                 140                 


Pro Asp Gly Ala Leu Asp Thr Ala Val Cys Ala Asp Glu Val Gly Ser 
145                 150                 155                 160 


Glu Glu Asp Leu Tyr Asp Asp Leu His Ser Ser Ser His His Tyr Ser 
                165                 170                 175     


His Pro Gly Gly Gly Gly Glu Gln Leu Ala Ile Asn Glu Leu Ile Ser 
            180                 185                 190         


Asp Gly Ser Val Val Cys Ala Glu Ala Leu Trp Asp His Val Thr Met 
        195                 200                 205             


Asp Asp Gln Glu Leu Gly Phe Lys Ala Gly Asp Val Ile Glu Val Met 
    210                 215                 220                 


Asp Ala Thr Asn Arg Glu Trp Trp Trp Gly Arg Val Ala Asp Gly Glu 
225                 230                 235                 240 


Gly Trp Phe Pro Ala Ser Phe Val Arg Leu Arg Val Asn Gln Asp Glu 
                245                 250                 255     


Pro Ala Asp Asp Asp Ala Pro Leu Ala Gly Asn Ser Gly Ala Glu Asp 
            260                 265                 270         


Gly Gly Ala Glu Ala Gln Ser Ser Lys Asp Gln Met Arg Thr Asn Val 
        275                 280                 285             


Ile Asn Glu Ile Leu Ser Thr Glu Arg Asp Tyr Ile Lys His Leu Arg 
    290                 295                 300                 


Asp Ile Cys Glu Gln Ala Asp Phe Gln Ile Tyr Ser Glu Tyr Cys Asn 
305                 310                 315                 320 


Asn His Pro Asn Ala Cys Val Glu Leu Ser Arg Leu Thr Lys Leu Ser 
                325                 330                 335     


Lys Tyr Val Tyr Phe Phe Glu Ala Cys Arg Leu Leu Gln Lys Met Ile 
            340                 345                 350         


Asp Ile Ser Leu Asp Gly Phe Leu Leu Thr Pro Val Gln Lys Ile Cys 
        355                 360                 365             


Lys Tyr Pro Leu Gln Leu Ala Glu Leu Leu Lys Tyr Thr His Pro Gln 
    370                 375                 380                 


His Arg Asp Phe Lys Asp Val Glu Ala Ala Leu His Ala Met Lys Asn 
385                 390                 395                 400 


Val Ala Gln Leu Ile Asn Glu Arg Lys Arg Arg Leu Glu Asn Ile Asp 
                405                 410                 415     


Lys Ile Ala Gln Trp Gln Ser Ser Ile Glu Asp Trp Glu Gly Glu Asp 
            420                 425                 430         


Leu Leu Val Arg Ser Ser Glu Leu Ile Tyr Ser Gly Glu Leu Thr Arg 
        435                 440                 445             


Val Thr Gln Pro Gln Ala Lys Ser Gln Gln Arg Met Phe Phe Leu Phe 
    450                 455                 460                 


Asp His Gln Leu Ile Tyr Cys Lys Lys Asp Leu Leu Arg Arg Asp Val 
465                 470                 475                 480 


Leu Tyr Tyr Lys Gly Arg Leu Asp Met Asp Gly Leu Glu Val Val Asp 
                485                 490                 495     


Leu Glu Asp Gly Lys Asp Arg Asp Leu His Val Ser Ile Lys Asn Ala 
            500                 505                 510         


Phe Arg Leu His Arg Gly Ala Thr Gly Asp Ser His Leu Leu Cys Thr 
        515                 520                 525             


Arg Lys Pro Glu Gln Lys Gln Arg Trp Leu Lys Ala Phe Ala Arg Glu 
    530                 535                 540                 


Arg Glu Gln Val Gln Leu Asp Gln Glu Thr Gly Phe Ser Ile Thr Glu 
545                 550                 555                 560 


Leu Gln Arg Lys Gln Ala Met Leu Asn Ala Ser Lys Gln Gln Val Thr 
                565                 570                 575     


Gly Lys Pro Lys Ala Val Gly Arg Pro Cys Tyr Leu Thr Arg Gln Lys 
            580                 585                 590         


His Pro Ala Leu Pro Ser Asn Arg Pro Gln Gln Gln Val Leu Val Leu 
        595                 600                 605             


Ala Glu Pro Arg Arg Lys Pro Ser Thr Phe Trp His Ser Ile Ser Arg 
    610                 615                 620                 


Leu Ala Pro Phe Arg Lys 
625                 630 


<210>  1053
<211>  192
<212>  PRT
<213>  Homo Sapiens

<400>  1053

Met Pro Trp Glu Glu Pro Ala Gly Glu Lys Pro Ser Cys Ser His Ser 
1               5                   10                  15      


Gln Lys Ala Phe His Met Glu Pro Ala Gln Lys Pro Cys Phe Thr Thr 
            20                  25                  30          


Asp Met Val Thr Trp Ala Leu Leu Cys Ile Ser Ala Glu Thr Val Arg 
        35                  40                  45              


Gly Glu Ala Pro Ser Gln Pro Arg Gly Ile Pro His Arg Ser Pro Val 
    50                  55                  60                  


Ser Val Asp Asp Leu Trp Leu Glu Lys Thr Gln Arg Lys Lys Leu Gln 
65                  70                  75                  80  


Lys Gln Ala His Val Glu Arg Arg Leu His Ile Gly Ala Val His Lys 
                85                  90                  95      


Asp Gly Val Lys Cys Trp Arg Lys Thr Ile Ile Thr Ser Pro Glu Ser 
            100                 105                 110         


Leu Asn Leu Pro Arg Arg Ser His Pro Leu Ser Gln Ser Ala Pro Thr 
        115                 120                 125             


Gly Leu Asn His Met Gly Trp Pro Glu His Thr Pro Gly Thr Ala Val 
    130                 135                 140                 


Gly Arg Pro Cys Tyr Leu Thr Arg Gln Lys His Pro Ala Leu Pro Ser 
145                 150                 155                 160 


Asn Arg Pro Gln Gln Gln Val Leu Val Leu Ala Glu Pro Arg Arg Lys 
                165                 170                 175     


Pro Ser Thr Phe Trp His Ser Ile Ser Arg Leu Ala Pro Phe Arg Lys 
            180                 185                 190         


<210>  1054
<211>  517
<212>  PRT
<213>  Homo Sapiens

<400>  1054

Met Arg Gly Ala Val Ser Arg Ser Trp Ser Leu Glu Ser Leu Arg Ser 
1               5                   10                  15      


Ala Thr Ala Ala Met Pro Asp Gly Ala Leu Asp Thr Ala Val Cys Ala 
            20                  25                  30          


Asp Glu Val Gly Ser Glu Glu Asp Leu Tyr Asp Asp Leu His Ser Ser 
        35                  40                  45              


Ser His His Tyr Ser His Pro Gly Gly Gly Gly Glu Gln Leu Ala Ile 
    50                  55                  60                  


Asn Glu Leu Ile Ser Asp Gly Ser Val Val Cys Ala Glu Ala Leu Trp 
65                  70                  75                  80  


Asp His Val Thr Met Asp Asp Gln Glu Leu Gly Phe Lys Ala Gly Asp 
                85                  90                  95      


Val Ile Glu Val Met Asp Ala Thr Asn Arg Glu Trp Trp Trp Gly Arg 
            100                 105                 110         


Val Ala Asp Gly Glu Gly Trp Phe Pro Ala Ser Phe Val Arg Leu Arg 
        115                 120                 125             


Val Asn Gln Asp Glu Pro Ala Asp Asp Asp Ala Pro Leu Ala Gly Asn 
    130                 135                 140                 


Ser Gly Ala Glu Asp Gly Gly Ala Glu Ala Gln Ser Ser Lys Asp Gln 
145                 150                 155                 160 


Met Arg Thr Asn Val Ile Asn Glu Ile Leu Ser Thr Glu Arg Asp Tyr 
                165                 170                 175     


Ile Lys His Leu Arg Asp Ile Cys Glu Gly Tyr Val Arg Gln Cys Arg 
            180                 185                 190         


Lys Arg Ala Asp Met Phe Ser Glu Glu Gln Leu Arg Thr Ile Phe Gly 
        195                 200                 205             


Asn Ile Glu Asp Ile Tyr Arg Cys Gln Lys Ala Phe Val Lys Ala Leu 
    210                 215                 220                 


Glu Gln Arg Phe Asn Arg Glu Arg Pro His Leu Ser Glu Leu Gly Ala 
225                 230                 235                 240 


Cys Phe Leu Glu His Gln Ala Asp Phe Gln Ile Tyr Ser Glu Tyr Cys 
                245                 250                 255     


Asn Asn His Pro Asn Ala Cys Val Glu Leu Ser Arg Leu Thr Lys Leu 
            260                 265                 270         


Ser Lys Tyr Val Tyr Phe Phe Glu Ala Cys Arg Leu Leu Gln Lys Met 
        275                 280                 285             


Ile Asp Ile Ser Leu Asp Gly Phe Leu Leu Thr Pro Val Gln Lys Ile 
    290                 295                 300                 


Cys Lys Tyr Pro Leu Gln Leu Ala Glu Leu Leu Lys Tyr Thr His Pro 
305                 310                 315                 320 


Gln His Arg Asp Phe Lys Asp Val Glu Ala Ala Leu His Ala Met Lys 
                325                 330                 335     


Asn Val Ala Gln Leu Ile Asn Glu Arg Lys Arg Arg Leu Glu Asn Ile 
            340                 345                 350         


Asp Lys Ile Ala Gln Trp Gln Ser Ser Ile Glu Asp Trp Glu Gly Glu 
        355                 360                 365             


Asp Leu Leu Val Arg Ser Ser Glu Leu Ile Tyr Ser Gly Glu Leu Thr 
    370                 375                 380                 


Arg Val Thr Gln Pro Gln Ala Lys Ser Gln Gln Arg Met Phe Phe Leu 
385                 390                 395                 400 


Phe Asp His Gln Leu Ile Tyr Cys Lys Lys Asp Leu Leu Arg Arg Asp 
                405                 410                 415     


Val Leu Tyr Tyr Lys Gly Arg Leu Asp Met Asp Gly Leu Glu Val Val 
            420                 425                 430         


Asp Leu Glu Asp Gly Lys Asp Arg Asp Leu His Val Ser Ile Lys Asn 
        435                 440                 445             


Ala Phe Arg Leu His Arg Gly Ala Thr Gly Asp Ser His Leu Leu Cys 
    450                 455                 460                 


Thr Arg Lys Pro Glu Gln Lys Gln Arg Trp Leu Lys Ala Phe Ala Arg 
465                 470                 475                 480 


Glu Arg Glu Gln Val Gln Leu Asp Gln Glu Thr Gly Phe Ser Ile Thr 
                485                 490                 495     


Glu Leu Gln Arg Lys Gln Ala Met Leu Asn Ala Ser Lys Gln Gln Val 
            500                 505                 510         


Thr Gly Lys Pro Lys 
        515         


<210>  1055
<211>  619
<212>  PRT
<213>  Homo Sapiens

<400>  1055

Met Arg Pro Asp Gly Gln Gln Ala Leu Asp Ala Val Val Arg Ser Phe 
1               5                   10                  15      


Asp Cys His Ser Glu Ala Ala Leu Arg Gln Arg Asn Asp Val Ile Tyr 
            20                  25                  30          


Cys Ser Leu Pro Arg Thr Ala Gln Gly Ile Val Gln Arg Glu Asp Gln 
        35                  40                  45              


Leu Glu Val Leu Val Ser Leu Arg Glu Val Trp Gly Arg Arg Arg Gly 
    50                  55                  60                  


Arg Asp Gly Thr Cys Thr Gly Ala Met Pro Asp Gly Ala Leu Asp Thr 
65                  70                  75                  80  


Ala Val Cys Ala Asp Glu Val Gly Ser Glu Glu Asp Leu Tyr Asp Asp 
                85                  90                  95      


Leu His Ser Ser Ser His His Tyr Ser His Pro Gly Gly Gly Gly Glu 
            100                 105                 110         


Gln Leu Ala Ile Asn Glu Leu Ile Ser Asp Gly Ser Val Val Cys Ala 
        115                 120                 125             


Glu Ala Leu Trp Asp His Val Thr Met Asp Asp Gln Glu Leu Gly Phe 
    130                 135                 140                 


Lys Ala Gly Asp Val Ile Glu Val Met Asp Ala Thr Asn Arg Glu Trp 
145                 150                 155                 160 


Trp Trp Gly Arg Val Ala Asp Gly Glu Gly Trp Phe Pro Ala Ser Phe 
                165                 170                 175     


Val Arg Leu Arg Val Asn Gln Asp Glu Pro Ala Asp Asp Asp Ala Pro 
            180                 185                 190         


Leu Ala Gly Asn Ser Gly Ala Glu Asp Gly Gly Ala Glu Ala Gln Ser 
        195                 200                 205             


Ser Lys Asp Gln Met Arg Thr Asn Val Ile Asn Glu Ile Leu Ser Thr 
    210                 215                 220                 


Glu Arg Asp Tyr Ile Lys His Leu Arg Asp Ile Cys Glu Gly Tyr Val 
225                 230                 235                 240 


Arg Gln Cys Arg Lys Arg Ala Asp Met Phe Ser Glu Glu Gln Leu Arg 
                245                 250                 255     


Thr Ile Phe Gly Asn Ile Glu Asp Ile Tyr Arg Cys Gln Lys Ala Phe 
            260                 265                 270         


Val Lys Ala Leu Glu Gln Arg Phe Asn Arg Glu Arg Pro His Leu Ser 
        275                 280                 285             


Glu Leu Gly Ala Cys Phe Leu Glu His Gln Ala Asp Phe Gln Ile Tyr 
    290                 295                 300                 


Ser Glu Tyr Cys Asn Asn His Pro Asn Ala Cys Val Glu Leu Ser Arg 
305                 310                 315                 320 


Leu Thr Lys Leu Ser Lys Tyr Val Tyr Phe Phe Glu Ala Cys Arg Leu 
                325                 330                 335     


Leu Gln Lys Met Ile Asp Ile Ser Leu Asp Gly Phe Leu Leu Thr Pro 
            340                 345                 350         


Val Gln Lys Ile Cys Lys Tyr Pro Leu Gln Leu Ala Glu Leu Leu Lys 
        355                 360                 365             


Tyr Thr His Pro Gln His Arg Asp Phe Lys Asp Val Glu Ala Ala Leu 
    370                 375                 380                 


His Ala Met Lys Asn Val Ala Gln Leu Ile Asn Glu Arg Lys Arg Arg 
385                 390                 395                 400 


Leu Glu Asn Ile Asp Lys Ile Ala Gln Trp Gln Ser Ser Ile Glu Asp 
                405                 410                 415     


Trp Glu Gly Glu Asp Leu Leu Val Arg Ser Ser Glu Leu Ile Tyr Ser 
            420                 425                 430         


Gly Glu Leu Thr Arg Val Thr Gln Pro Gln Ala Lys Ser Gln Gln Arg 
        435                 440                 445             


Met Phe Phe Leu Phe Asp His Gln Leu Ile Tyr Cys Lys Lys Asp Leu 
    450                 455                 460                 


Leu Arg Arg Asp Val Leu Tyr Tyr Lys Gly Arg Leu Asp Met Asp Gly 
465                 470                 475                 480 


Leu Glu Val Val Asp Leu Glu Asp Gly Lys Asp Arg Asp Leu His Val 
                485                 490                 495     


Ser Ile Lys Asn Ala Phe Arg Leu His Arg Gly Ala Thr Gly Asp Ser 
            500                 505                 510         


His Leu Leu Cys Thr Arg Lys Pro Glu Gln Lys Gln Arg Trp Leu Lys 
        515                 520                 525             


Ala Phe Ala Arg Glu Arg Glu Gln Val Gln Leu Asp Gln Glu Thr Gly 
    530                 535                 540                 


Phe Ser Ile Thr Glu Leu Gln Arg Lys Gln Ala Met Leu Asn Ala Ser 
545                 550                 555                 560 


Lys Gln Gln Val Thr Gly Lys Pro Lys Ala Val Gly Arg Pro Cys Tyr 
                565                 570                 575     


Leu Thr Arg Gln Lys His Pro Ala Leu Pro Ser Asn Arg Pro Gln Gln 
            580                 585                 590         


Gln Val Leu Val Leu Ala Glu Pro Arg Arg Lys Pro Ser Thr Phe Trp 
        595                 600                 605             


His Ser Ile Ser Arg Leu Ala Pro Phe Arg Lys 
    610                 615                 


<210>  1056
<211>  372
<212>  PRT
<213>  Homo Sapiens

<400>  1056

Pro Leu Ala Ser Thr Pro Leu Ser Ser Ser Leu Val Ser Pro Glu His 
1               5                   10                  15      


Arg Arg Lys Ser Glu Pro Thr Ile Lys Cys Thr Ala Thr Gln Glu Gly 
            20                  25                  30          


Gly Arg Tyr Leu Pro Ser Gly Ile Phe Pro Glu Lys Ser Trp Leu Ala 
        35                  40                  45              


Ser Pro Gly Ser Pro Arg Ala Gln Gln Ala Gly Ile Ala His Thr Leu 
    50                  55                  60                  


Pro Ser Ser Ser Ala Cys Cys Leu Ala Tyr Glu Asn Pro Gly Thr Pro 
65                  70                  75                  80  


Cys Arg Pro Thr Ser Pro Lys Pro Leu Ser Pro Arg Pro Ser Ala Gln 
                85                  90                  95      


Arg Met Gly Leu His Tyr Pro Gly Arg Gly Ser Ala Ile Ser Met Val 
            100                 105                 110         


Ser Leu Gly Ser Tyr Ser Tyr Val Asp Ser Ser Ser Gly Asp Pro Glu 
        115                 120                 125             


Arg Pro Lys Ile Pro Lys Gly Gln Thr Ser Phe Leu Leu Ser Leu Gln 
    130                 135                 140                 


Thr Leu Asn Gln Asp Glu Gln Lys Glu Glu Ser Arg Glu Gly Gly Gln 
145                 150                 155                 160 


Gly Pro Arg Gly Leu Gly Thr Val Pro Trp Leu Arg Asp Leu Pro Gly 
                165                 170                 175     


Ser Glu Asn His Met Pro Trp Glu Glu Pro Ala Gly Glu Lys Pro Ser 
            180                 185                 190         


Cys Ser His Ser Gln Lys Ala Phe His Met Glu Pro Ala Gln Lys Pro 
        195                 200                 205             


Cys Phe Thr Thr Asp Met Val Thr Trp Ala Leu Leu Cys Ile Ser Ala 
    210                 215                 220                 


Glu Thr Val Arg Gly Glu Ala Pro Ser Gln Pro Arg Gly Ile Pro His 
225                 230                 235                 240 


Arg Ser Pro Val Ser Val Asp Asp Leu Trp Leu Glu Lys Thr Gln Arg 
                245                 250                 255     


Lys Lys Leu Gln Lys Gln Ala His Val Glu Arg Arg Leu His Ile Gly 
            260                 265                 270         


Ala Val His Lys Asp Gly Val Lys Cys Trp Arg Lys Thr Ile Ile Thr 
        275                 280                 285             


Ser Pro Glu Ser Leu Asn Leu Pro Arg Arg Ser His Pro Leu Ser Gln 
    290                 295                 300                 


Ser Ala Pro Thr Gly Leu Asn His Met Gly Trp Pro Glu His Thr Pro 
305                 310                 315                 320 


Gly Thr Ala Val Gly Arg Pro Cys Tyr Leu Thr Arg Gln Lys His Pro 
                325                 330                 335     


Ala Leu Pro Ser Asn Arg Pro Gln Gln Gln Val Leu Val Leu Ala Glu 
            340                 345                 350         


Pro Arg Arg Lys Pro Ser Thr Phe Trp His Ser Ile Ser Arg Leu Ala 
        355                 360                 365             


Pro Phe Arg Lys 
    370         


<210>  1057
<211>  287
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1057

Xaa Ala Cys Val Glu Leu Ser Arg Leu Thr Lys Leu Ser Lys Tyr Val 
1               5                   10                  15      


Tyr Phe Phe Glu Ala Cys Arg Leu Leu Gln Lys Met Ile Asp Ile Ser 
            20                  25                  30          


Leu Asp Gly Phe Leu Leu Thr Pro Val Gln Lys Ile Cys Lys Tyr Pro 
        35                  40                  45              


Leu Gln Leu Ala Glu Leu Leu Lys Tyr Thr His Pro Gln His Arg Asp 
    50                  55                  60                  


Phe Lys Asp Val Glu Ala Ala Leu His Ala Met Lys Asn Val Ala Gln 
65                  70                  75                  80  


Leu Ile Asn Glu Arg Lys Arg Arg Leu Glu Asn Ile Asp Lys Ile Ala 
                85                  90                  95      


Gln Trp Gln Ser Ser Ile Glu Asp Trp Glu Gly Glu Asp Leu Leu Val 
            100                 105                 110         


Arg Ser Ser Glu Leu Ile Tyr Ser Gly Glu Leu Thr Arg Val Thr Gln 
        115                 120                 125             


Pro Gln Ala Lys Ser Gln Gln Arg Met Phe Phe Leu Phe Asp His Gln 
    130                 135                 140                 


Leu Ile Tyr Cys Lys Lys Asp Leu Leu Arg Arg Asp Val Leu Tyr Tyr 
145                 150                 155                 160 


Lys Gly Arg Leu Asp Met Asp Gly Leu Glu Val Val Asp Leu Glu Asp 
                165                 170                 175     


Gly Lys Asp Arg Asp Leu His Val Ser Ile Lys Asn Ala Phe Arg Leu 
            180                 185                 190         


His Arg Gly Ala Thr Gly Asp Ser His Leu Leu Cys Thr Arg Lys Pro 
        195                 200                 205             


Glu Gln Lys Gln Arg Trp Leu Lys Ala Phe Ala Arg Glu Arg Glu Gln 
    210                 215                 220                 


Val Gln Leu Asp Gln Glu Thr Gly Phe Ser Ile Thr Glu Leu Gln Arg 
225                 230                 235                 240 


Lys Gln Ala Met Leu Asn Ala Ser Lys Gln Gln Val Thr Gly Lys Pro 
                245                 250                 255     


Lys Gly Arg Arg Thr Ala Ala Pro Pro Pro Arg Leu Pro Gly Pro Tyr 
            260                 265                 270         


Pro Ala Asp Ile Ile Pro Phe Ser Glu Pro Gln Ser Gln Ala Ser 
        275                 280                 285         


<210>  1058
<211>  695
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1058

Xaa Glu Gly Gly Gln Gly Pro Arg Gly Leu Gly Thr Val Pro Trp Leu 
1               5                   10                  15      


Arg Asp Leu Pro Gly Ser Glu Asn His Met Pro Trp Glu Glu Pro Ala 
            20                  25                  30          


Gly Glu Lys Pro Ser Cys Ser His Ser Gln Lys Ala Phe His Met Glu 
        35                  40                  45              


Pro Ala Gln Lys Pro Cys Phe Thr Thr Asp Met Val Thr Trp Ala Leu 
    50                  55                  60                  


Leu Cys Ile Ser Ala Glu Thr Val Arg Gly Glu Ala Pro Ser Gln Pro 
65                  70                  75                  80  


Arg Gly Ile Pro His Arg Ser Pro Val Ser Val Asp Asp Leu Trp Leu 
                85                  90                  95      


Glu Lys Thr Gln Arg Lys Lys Leu Gln Lys Gln Ala His Val Glu Arg 
            100                 105                 110         


Arg Leu His Ile Gly Ala Val His Lys Asp Gly Val Lys Cys Trp Arg 
        115                 120                 125             


Lys Thr Ile Ile Thr Ser Pro Glu Ser Leu Asn Leu Pro Arg Arg Ser 
    130                 135                 140                 


His Pro Leu Ser Gln Ser Ala Pro Thr Gly Leu Asn His Met Gly Trp 
145                 150                 155                 160 


Pro Glu His Thr Pro Gly Thr Ala Met Pro Asp Gly Ala Leu Asp Thr 
                165                 170                 175     


Ala Val Cys Ala Asp Glu Val Gly Ser Glu Glu Asp Leu Tyr Asp Asp 
            180                 185                 190         


Leu His Ser Ser Ser His His Tyr Ser His Pro Gly Gly Gly Gly Glu 
        195                 200                 205             


Gln Leu Ala Ile Asn Glu Leu Ile Ser Asp Gly Ser Val Val Cys Ala 
    210                 215                 220                 


Glu Ala Leu Trp Asp His Val Thr Met Asp Asp Gln Glu Leu Gly Phe 
225                 230                 235                 240 


Lys Ala Gly Asp Val Ile Glu Val Met Asp Ala Thr Asn Arg Glu Trp 
                245                 250                 255     


Trp Trp Gly Arg Val Ala Asp Gly Glu Gly Trp Phe Pro Ala Ser Phe 
            260                 265                 270         


Val Arg Leu Arg Val Asn Gln Asp Glu Pro Ala Asp Asp Asp Ala Pro 
        275                 280                 285             


Leu Ala Gly Asn Ser Gly Ala Glu Asp Gly Gly Ala Glu Ala Gln Ser 
    290                 295                 300                 


Ser Lys Asp Gln Met Arg Thr Asn Val Ile Asn Glu Ile Leu Ser Thr 
305                 310                 315                 320 


Glu Arg Asp Tyr Ile Lys His Leu Arg Asp Ile Cys Glu Gly Tyr Val 
                325                 330                 335     


Arg Gln Cys Arg Lys Arg Ala Asp Met Phe Ser Glu Glu Gln Leu Arg 
            340                 345                 350         


Thr Ile Phe Gly Asn Ile Glu Asp Ile Tyr Arg Cys Gln Lys Ala Phe 
        355                 360                 365             


Val Lys Ala Leu Glu Gln Arg Phe Asn Arg Glu Arg Pro His Leu Ser 
    370                 375                 380                 


Glu Leu Gly Ala Cys Phe Leu Glu His Gln Ala Asp Phe Gln Ile Tyr 
385                 390                 395                 400 


Ser Glu Tyr Cys Asn Asn His Pro Asn Ala Cys Val Glu Leu Ser Arg 
                405                 410                 415     


Leu Thr Lys Leu Ser Lys Tyr Val Tyr Phe Phe Glu Ala Cys Arg Leu 
            420                 425                 430         


Leu Gln Lys Met Ile Asp Ile Ser Leu Asp Gly Phe Leu Leu Thr Pro 
        435                 440                 445             


Val Gln Lys Ile Cys Lys Tyr Pro Leu Gln Leu Ala Glu Leu Leu Lys 
    450                 455                 460                 


Tyr Thr His Pro Gln His Arg Asp Phe Lys Asp Val Glu Ala Ala Leu 
465                 470                 475                 480 


His Ala Met Lys Asn Val Ala Gln Leu Ile Asn Glu Arg Lys Arg Arg 
                485                 490                 495     


Leu Glu Asn Ile Asp Lys Ile Ala Gln Trp Gln Ser Ser Ile Glu Asp 
            500                 505                 510         


Trp Glu Gly Glu Asp Leu Leu Val Arg Ser Ser Glu Leu Ile Tyr Ser 
        515                 520                 525             


Gly Glu Leu Thr Arg Val Thr Gln Pro Gln Ala Lys Ser Gln Gln Arg 
    530                 535                 540                 


Met Phe Phe Leu Phe Asp His Gln Leu Ile Tyr Cys Lys Lys Asp Leu 
545                 550                 555                 560 


Leu Arg Arg Asp Val Leu Tyr Tyr Lys Gly Arg Leu Asp Met Asp Gly 
                565                 570                 575     


Leu Glu Val Val Asp Leu Glu Asp Gly Lys Asp Arg Asp Leu His Val 
            580                 585                 590         


Ser Ile Lys Asn Ala Phe Arg Leu His Arg Gly Ala Thr Gly Asp Ser 
        595                 600                 605             


His Leu Leu Cys Thr Arg Lys Pro Glu Gln Lys Gln Arg Trp Leu Lys 
    610                 615                 620                 


Ala Phe Ala Arg Glu Arg Glu Gln Val Gln Leu Asp Gln Glu Thr Gly 
625                 630                 635                 640 


Phe Ser Ile Thr Glu Leu Gln Arg Lys Gln Ala Met Leu Asn Ala Ser 
                645                 650                 655     


Lys Gln Gln Val Thr Gly Lys Pro Lys Gly Arg Arg Thr Ala Ala Pro 
            660                 665                 670         


Pro Pro Arg Leu Pro Gly Pro Tyr Pro Ala Asp Ile Ile Pro Phe Ser 
        675                 680                 685             


Glu Pro Gln Ser Gln Ala Ser 
    690                 695 


<210>  1059
<211>  142
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1059

Xaa Lys Lys Leu Arg Ala Arg Leu Ala Leu Ala His Lys Thr Phe Ser 
1               5                   10                  15      


Asn Phe Ile Glu Ser Ile Val Leu Glu Lys Glu Asn Thr His Glu Arg 
            20                  25                  30          


Ser Pro Ser Ser Pro Lys Gly Glu Lys Glu Lys Ser Arg Leu Arg Gln 
        35                  40                  45              


Gly Ser Trp Arg Ala Phe Leu Lys Ser Lys Asp Ala Gly Ser Pro Lys 
    50                  55                  60                  


Lys Pro Thr Leu Val Ser Leu Pro Leu Gly Pro Glu Val Leu Ser Pro 
65                  70                  75                  80  


Ala Glu Thr Asp Ser His Cys Glu Glu Arg Ala Glu Asp Lys Glu Gly 
                85                  90                  95      


Tyr Val Phe Ser Asp His Trp Ala Pro Pro Leu Ala Ser Thr Pro Leu 
            100                 105                 110         


Ser Ser Ser Leu Val Ser Pro Glu His Arg Arg Lys Ser Glu Pro Thr 
        115                 120                 125             


Ile Lys Cys Thr Ala Thr Gln Glu Gly Asp Ala Lys Pro Arg 
    130                 135                 140         


<210>  1060
<211>  173
<212>  PRT
<213>  Homo Sapiens

<400>  1060

Met Cys Leu Leu Leu Gly Ala Thr Gly Val Gly Lys Thr Leu Leu Val 
1               5                   10                  15      


Lys Arg Leu Gln Glu Val Ser Ser Arg Asp Gly Lys Gly Asp Leu Gly 
            20                  25                  30          


Glu Pro Pro Pro Thr Arg Pro Thr Val Gly Thr Asn Leu Thr Asp Ile 
        35                  40                  45              


Val Ala Gln Arg Lys Ile Thr Ile Arg Glu Leu Gly Gly Cys Met Gly 
    50                  55                  60                  


Pro Ile Trp Ser Ser Tyr Tyr Gly Asn Cys Arg Ser Leu Leu Phe Val 
65                  70                  75                  80  


Met Asp Ala Ser Asp Pro Thr Gln Leu Ser Ala Ser Cys Val Gln Leu 
                85                  90                  95      


Leu Gly Leu Leu Ser Ala Glu Gln Leu Ala Glu Ala Ser Val Leu Ile 
            100                 105                 110         


Leu Phe Asn Lys Ile Asp Leu Pro Cys Tyr Met Ser Thr Glu Glu Met 
        115                 120                 125             


Lys Ser Leu Ile Arg Leu Pro Asp Ile Ile Ala Cys Ala Lys Gln Asn 
    130                 135                 140                 


Ile Thr Thr Ala Glu Ile Ser Ala Arg Glu Gly Thr Gly Leu Ala Gly 
145                 150                 155                 160 


Val Leu Ala Trp Leu Gln Ala Thr His Arg Ala Asn Asp 
                165                 170             


<210>  1061
<211>  93
<212>  PRT
<213>  Homo Sapiens

<400>  1061

Met Asp Ala Ser Asp Pro Thr Gln Leu Ser Ala Ser Cys Val Gln Leu 
1               5                   10                  15      


Leu Gly Leu Leu Ser Ala Glu Gln Leu Ala Glu Ala Ser Val Leu Ile 
            20                  25                  30          


Leu Phe Asn Lys Ile Asp Leu Pro Cys Tyr Met Ser Thr Glu Glu Met 
        35                  40                  45              


Lys Ser Leu Ile Arg Leu Pro Asp Ile Ile Ala Cys Ala Lys Gln Asn 
    50                  55                  60                  


Ile Thr Thr Ala Glu Ile Ser Ala Arg Glu Gly Thr Gly Leu Ala Gly 
65                  70                  75                  80  


Val Leu Ala Trp Leu Gln Ala Thr His Arg Ala Asn Asp 
                85                  90              


<210>  1062
<211>  93
<212>  PRT
<213>  Homo Sapiens

<400>  1062

Met Asp Ala Ser Asp Pro Thr Gln Leu Ser Ala Ser Cys Val Gln Leu 
1               5                   10                  15      


Leu Gly Leu Leu Ser Ala Glu Gln Leu Ala Glu Ala Ser Val Leu Ile 
            20                  25                  30          


Leu Phe Asn Lys Ile Asp Leu Pro Cys Tyr Met Ser Thr Glu Glu Met 
        35                  40                  45              


Lys Ser Leu Ile Arg Leu Pro Asp Ile Ile Ala Cys Ala Lys Gln Asn 
    50                  55                  60                  


Ile Thr Thr Ala Glu Ile Ser Ala Arg Glu Gly Thr Gly Leu Ala Gly 
65                  70                  75                  80  


Val Leu Ala Trp Leu Gln Ala Thr His Arg Ala Asn Asp 
                85                  90              


<210>  1063
<211>  93
<212>  PRT
<213>  Homo Sapiens

<400>  1063

Met Asp Ala Ser Asp Pro Thr Gln Leu Ser Ala Ser Cys Val Gln Leu 
1               5                   10                  15      


Leu Gly Leu Leu Ser Ala Glu Gln Leu Ala Glu Ala Ser Val Leu Ile 
            20                  25                  30          


Leu Phe Asn Lys Ile Asp Leu Pro Cys Tyr Met Ser Thr Glu Glu Met 
        35                  40                  45              


Lys Ser Leu Ile Arg Leu Pro Asp Ile Ile Ala Cys Ala Lys Gln Asn 
    50                  55                  60                  


Ile Thr Thr Ala Glu Ile Ser Ala Arg Glu Gly Thr Gly Leu Ala Gly 
65                  70                  75                  80  


Val Leu Ala Trp Leu Gln Ala Thr His Arg Ala Asn Asp 
                85                  90              


<210>  1064
<211>  111
<212>  PRT
<213>  Homo Sapiens

<400>  1064

Met Gly Pro Ile Trp Ser Ser Tyr Tyr Gly Asn Cys Arg Ser Leu Leu 
1               5                   10                  15      


Phe Val Met Asp Ala Ser Asp Pro Thr Gln Leu Ser Ala Ser Cys Val 
            20                  25                  30          


Gln Leu Leu Gly Leu Leu Ser Ala Glu Gln Leu Ala Glu Ala Ser Val 
        35                  40                  45              


Leu Ile Leu Phe Asn Lys Ile Asp Leu Pro Cys Tyr Met Ser Thr Glu 
    50                  55                  60                  


Glu Met Lys Ser Leu Ile Arg Leu Pro Asp Ile Ile Ala Cys Ala Lys 
65                  70                  75                  80  


Gln Asn Ile Thr Thr Ala Glu Ile Ser Ala Arg Glu Gly Thr Gly Leu 
                85                  90                  95      


Ala Gly Val Leu Ala Trp Leu Gln Ala Thr His Arg Ala Asn Asp 
            100                 105                 110     


<210>  1065
<211>  111
<212>  PRT
<213>  Homo Sapiens

<400>  1065

Met Gly Pro Ile Trp Ser Ser Tyr Tyr Gly Asn Cys Arg Ser Leu Leu 
1               5                   10                  15      


Phe Val Met Asp Ala Ser Asp Pro Thr Gln Leu Ser Ala Ser Cys Val 
            20                  25                  30          


Gln Leu Leu Gly Leu Leu Ser Ala Glu Gln Leu Ala Glu Ala Ser Val 
        35                  40                  45              


Leu Ile Leu Phe Asn Lys Ile Asp Leu Pro Cys Tyr Met Ser Thr Glu 
    50                  55                  60                  


Glu Met Lys Ser Leu Ile Arg Leu Pro Asp Ile Ile Ala Cys Ala Lys 
65                  70                  75                  80  


Gln Asn Ile Thr Thr Ala Glu Ile Ser Ala Arg Glu Gly Thr Gly Leu 
                85                  90                  95      


Ala Gly Val Leu Ala Trp Leu Gln Ala Thr His Arg Ala Asn Asp 
            100                 105                 110     


<210>  1066
<211>  197
<212>  PRT
<213>  Homo Sapiens

<400>  1066

Met Arg Val Ala Gly Gly Arg Ala Leu Ser Arg Gly Ala Glu Leu Arg 
1               5                   10                  15      


Val Pro Gly Gly Ala Lys His Gly Met Cys Leu Leu Leu Gly Ala Thr 
            20                  25                  30          


Gly Val Gly Lys Thr Leu Leu Val Lys Arg Leu Gln Glu Val Ser Ser 
        35                  40                  45              


Arg Asp Gly Lys Gly Asp Leu Gly Glu Pro Pro Pro Thr Arg Pro Thr 
    50                  55                  60                  


Val Gly Thr Asn Leu Thr Asp Ile Val Ala Gln Arg Lys Ile Thr Ile 
65                  70                  75                  80  


Arg Glu Leu Gly Gly Cys Met Gly Pro Ile Trp Ser Ser Tyr Tyr Gly 
                85                  90                  95      


Asn Cys Arg Ser Leu Leu Phe Val Met Asp Ala Ser Asp Pro Thr Gln 
            100                 105                 110         


Leu Ser Ala Ser Cys Val Gln Leu Leu Gly Leu Leu Ser Ala Glu Gln 
        115                 120                 125             


Leu Ala Glu Ala Ser Val Leu Ile Leu Phe Asn Lys Ile Asp Leu Pro 
    130                 135                 140                 


Cys Tyr Met Ser Thr Glu Glu Met Lys Ser Leu Ile Arg Leu Pro Asp 
145                 150                 155                 160 


Ile Ile Ala Cys Ala Lys Gln Asn Ile Thr Thr Ala Glu Ile Ser Ala 
                165                 170                 175     


Arg Glu Gly Thr Gly Leu Ala Gly Val Leu Ala Trp Leu Gln Ala Thr 
            180                 185                 190         


His Arg Ala Asn Asp 
        195         


<210>  1067
<211>  197
<212>  PRT
<213>  Homo Sapiens

<400>  1067

Met Arg Val Ala Gly Gly Arg Ala Leu Ser Arg Gly Ala Glu Leu Arg 
1               5                   10                  15      


Val Pro Gly Gly Ala Lys His Gly Met Cys Leu Leu Leu Gly Ala Thr 
            20                  25                  30          


Gly Val Gly Lys Thr Leu Leu Val Lys Arg Leu Gln Glu Val Ser Ser 
        35                  40                  45              


Arg Asp Gly Lys Gly Asp Leu Gly Glu Pro Pro Pro Thr Arg Pro Thr 
    50                  55                  60                  


Val Gly Thr Asn Leu Thr Asp Ile Val Ala Gln Arg Lys Ile Thr Ile 
65                  70                  75                  80  


Arg Glu Leu Gly Gly Cys Met Gly Pro Ile Trp Ser Ser Tyr Tyr Gly 
                85                  90                  95      


Asn Cys Arg Ser Leu Leu Phe Val Met Asp Ala Ser Asp Pro Thr Gln 
            100                 105                 110         


Leu Ser Ala Ser Cys Val Gln Leu Leu Gly Leu Leu Ser Ala Glu Gln 
        115                 120                 125             


Leu Ala Glu Ala Ser Val Leu Ile Leu Phe Asn Lys Ile Asp Leu Pro 
    130                 135                 140                 


Cys Tyr Met Ser Thr Glu Glu Met Lys Ser Leu Ile Arg Leu Pro Asp 
145                 150                 155                 160 


Ile Ile Ala Cys Ala Lys Gln Asn Ile Thr Thr Ala Glu Ile Ser Ala 
                165                 170                 175     


Arg Glu Gly Thr Gly Leu Ala Gly Val Leu Ala Trp Leu Gln Ala Thr 
            180                 185                 190         


His Arg Ala Asn Asp 
        195         


<210>  1068
<211>  48
<212>  PRT
<213>  Homo Sapiens

<400>  1068

Val Gly Thr Asn Leu Thr Asp Ile Val Ala Gln Arg Lys Ile Thr Ile 
1               5                   10                  15      


Arg Glu Leu Gly Gly Cys Met Gly Pro Ile Trp Ser Ser Tyr Tyr Gly 
            20                  25                  30          


Asn Cys Arg Ser Leu Leu Ala Cys Ala Ala Asp Thr Ser Met Glu Asn 
        35                  40                  45              


<210>  1069
<211>  935
<212>  PRT
<213>  Homo Sapiens

<400>  1069

Met Ala Ala Ala Lys Pro Thr Leu Thr Asp Ser Leu Ser Phe Cys Leu 
1               5                   10                  15      


Ala Gln Leu Ala Ala Ala Ala Gly Glu Ala Leu Gly Gly Glu Lys Asp 
            20                  25                  30          


Pro Ala Thr Asn Glu Thr Pro Leu Ser Arg Ala Leu Leu Ala Leu Arg 
        35                  40                  45              


Thr Arg His Ile Lys Ala Ala Gly Gly Ile Glu Arg Phe Arg Ala Arg 
    50                  55                  60                  


Gly Gly Leu Arg Pro Leu Leu Ala Leu Leu Arg Arg Ala Ala Ala Ala 
65                  70                  75                  80  


Gly Ser Ala Pro Ser Gln Ala Gly Pro Gly Ser Ala Pro Ser Ser Ala 
                85                  90                  95      


Ala Ser Gly Ala Ser Ser Pro Ala Pro Ala Ser Gly Pro Ala Pro Ser 
            100                 105                 110         


Ala Val Ser Ser Ser Ser Pro Thr Pro Pro Val Arg Leu Arg Lys Thr 
        115                 120                 125             


Leu Asp Leu Ala Leu Ser Ile Leu Ala Asp Cys Cys Thr Glu Gly Ala 
    130                 135                 140                 


Cys Arg Thr Glu Val Arg Arg Leu Gly Gly Ile Leu Pro Leu Val Thr 
145                 150                 155                 160 


Ile Leu Gln Cys Met Lys Thr Asp Ser Ile Gln Asn Arg Thr Ala Arg 
                165                 170                 175     


Ala Leu Gly Asn Leu Ala Met Glu Pro Glu Ser Cys Gly Asp Ile His 
            180                 185                 190         


Cys Ala Gly Ala Val Pro Leu Leu Val Glu Ser Leu Thr Ala Cys Gln 
        195                 200                 205             


Asp Ser Gln Cys Leu Gln Ser Val Val Arg Ala Leu Arg Asn Leu Ala 
    210                 215                 220                 


Asp Ser Pro Gln His Arg Leu Ala Leu Ala Gln Gln Gly Ala Val Arg 
225                 230                 235                 240 


Pro Leu Ala Glu Leu Leu Ala Thr Ala Pro Asp Ala Ala Leu Thr Leu 
                245                 250                 255     


Ala Leu Val Arg Ala Leu Leu Glu Leu Ser Arg Gly Cys Ser Arg Ala 
            260                 265                 270         


Cys Ala Glu Gln Leu Ser Leu Gly Gly Gly Leu Gly Pro Leu Val Ser 
        275                 280                 285             


Leu Ala Ser His Pro Lys Arg Ala Val Arg Glu Gly Thr Ile Leu Ile 
    290                 295                 300                 


Leu Ala Asn Leu Cys Ala Gln Gly Leu Ile Arg Pro Ala Leu Gly Asn 
305                 310                 315                 320 


Ala Gly Gly Val Glu Val Leu Val Asp Glu Leu Arg Gln Arg Arg Asp 
                325                 330                 335     


Pro Asn Gly Ala Ser Pro Thr Ser Gln Gln Pro Leu Val Arg Ala Val 
            340                 345                 350         


Cys Leu Leu Cys Arg Glu Ala Ile Asn Arg Ala Arg Leu Arg Asp Ala 
        355                 360                 365             


Gly Gly Leu Asp Leu Leu Met Gly Leu Leu Arg Asp Pro Arg Ala Ser 
    370                 375                 380                 


Ala Trp His Pro Arg Ile Val Ala Ala Leu Val Gly Phe Leu Tyr Asp 
385                 390                 395                 400 


Thr Gly Ala Leu Gly Arg Leu Gln Ala Leu Gly Leu Val Pro Leu Leu 
                405                 410                 415     


Ala Gly Gln Leu Cys Gly Glu Ala Gly Glu Glu Glu Glu Glu Gly Arg 
            420                 425                 430         


Glu Ala Ala Ser Trp Asp Phe Pro Glu Glu Arg Thr Pro Glu Arg Ala 
        435                 440                 445             


Gln Gly Gly Ser Phe Arg Ser Leu Arg Ser Trp Leu Ile Ser Glu Gly 
    450                 455                 460                 


Tyr Ala Thr Gly Pro Asp Asp Ile Ser Pro Asp Trp Ser Pro Glu Gln 
465                 470                 475                 480 


Cys Pro Pro Glu Pro Met Glu Pro Ala Ser Pro Ala Pro Thr Pro Thr 
                485                 490                 495     


Ser Leu Arg Ala Pro Arg Thr Gln Arg Thr Pro Gly Arg Ser Pro Ala 
            500                 505                 510         


Ala Ala Ile Glu Glu Pro Trp Gly Arg Glu Gly Pro Ala Leu Leu Leu 
        515                 520                 525             


Leu Ser Arg Phe Ser Gln Ala Pro Asp Pro Ser Gly Ala Leu Val Thr 
    530                 535                 540                 


Gly Pro Ala Leu Tyr Gly Leu Leu Thr Tyr Val Thr Gly Ala Pro Gly 
545                 550                 555                 560 


Pro Pro Ser Pro Arg Ala Leu Arg Ile Leu Ser Arg Leu Thr Cys Asn 
                565                 570                 575     


Pro Ala Cys Leu Glu Ala Phe Val Arg Ser Tyr Gly Ala Ala Leu Leu 
            580                 585                 590         


Arg Ala Trp Leu Val Leu Gly Val Ala Pro Asp Asp Trp Pro Ala Pro 
        595                 600                 605             


Arg Ala Arg Pro Thr Leu His Ser Arg His Arg Glu Leu Gly Glu Arg 
    610                 615                 620                 


Leu Leu Gln Asn Leu Thr Val Gln Ala Glu Ser Pro Phe Gly Val Gly 
625                 630                 635                 640 


Ala Leu Thr His Leu Leu Leu Ser Gly Ser Pro Glu Asp Arg Val Ala 
                645                 650                 655     


Cys Ala Leu Thr Leu Pro Phe Ile Cys Arg Lys Pro Ser Leu Trp Arg 
            660                 665                 670         


Arg Leu Leu Leu Glu Gln Gly Gly Leu Arg Leu Leu Leu Ala Ala Leu 
        675                 680                 685             


Thr Arg Pro Ala Pro His Pro Leu Phe Leu Phe Phe Ala Ala Asp Ser 
    690                 695                 700                 


Leu Ser Cys Leu Gln Asp Leu Val Ser Pro Thr Val Ser Pro Ala Val 
705                 710                 715                 720 


Pro Gln Ala Val Pro Met Asp Leu Asp Ser Pro Ser Pro Cys Leu Tyr 
                725                 730                 735     


Glu Pro Leu Leu Gly Pro Ala Pro Val Pro Ala Pro Asp Leu His Phe 
            740                 745                 750         


Leu Leu Asp Ser Gly Leu Gln Leu Pro Ala Gln Arg Ala Ala Ser Ala 
        755                 760                 765             


Thr Ala Ser Pro Phe Phe Arg Ala Leu Leu Ser Gly Ser Phe Ala Glu 
    770                 775                 780                 


Ala Gln Met Asp Leu Val Pro Leu Arg Gly Leu Ser Pro Gly Ala Ala 
785                 790                 795                 800 


Trp Pro Val Leu His His Leu His Gly Cys Arg Gly Cys Gly Ala Ala 
                805                 810                 815     


Leu Gly Pro Val Pro Pro Pro Gly Gln Pro Leu Leu Gly Ser Glu Ala 
            820                 825                 830         


Glu Glu Ala Leu Glu Ala Ala Gly Arg Phe Leu Leu Pro Gly Leu Glu 
        835                 840                 845             


Glu Glu Leu Glu Glu Ala Val Gly Arg Ile His Leu Gly Pro Gln Gly 
    850                 855                 860                 


Gly Pro Glu Ser Val Gly Glu Val Phe Arg Leu Gly Arg Pro Arg Leu 
865                 870                 875                 880 


Ala Ala His Cys Ala Arg Trp Thr Leu Gly Ser Glu Gln Cys Pro Arg 
                885                 890                 895     


Lys Arg Gly Leu Ala Leu Val Gly Leu Val Glu Ala Ala Gly Glu Glu 
            900                 905                 910         


Ala Gly Pro Leu Thr Glu Ala Leu Leu Ala Val Val Met Gly Ile Glu 
        915                 920                 925             


Leu Gly Ala Arg Val Pro Ala 
    930                 935 


<210>  1070
<211>  935
<212>  PRT
<213>  Homo Sapiens

<400>  1070

Met Ala Ala Ala Lys Pro Thr Leu Thr Asp Ser Leu Ser Phe Cys Leu 
1               5                   10                  15      


Ala Gln Leu Ala Ala Ala Ala Gly Glu Ala Leu Gly Gly Glu Lys Asp 
            20                  25                  30          


Pro Ala Thr Asn Glu Thr Pro Leu Ser Arg Ala Leu Leu Ala Leu Arg 
        35                  40                  45              


Thr Arg His Ile Lys Ala Ala Gly Gly Ile Glu Arg Phe Arg Ala Arg 
    50                  55                  60                  


Gly Gly Leu Arg Pro Leu Leu Ala Leu Leu Arg Arg Ala Ala Ala Ala 
65                  70                  75                  80  


Gly Ser Ala Pro Ser Gln Ala Gly Pro Gly Ser Ala Pro Ser Ser Ala 
                85                  90                  95      


Ala Ser Gly Ala Ser Ser Pro Ala Pro Ala Ser Gly Pro Ala Pro Ser 
            100                 105                 110         


Ala Val Ser Ser Ser Ser Pro Thr Pro Pro Val Arg Leu Arg Lys Thr 
        115                 120                 125             


Leu Asp Leu Ala Leu Ser Ile Leu Ala Asp Cys Cys Thr Glu Gly Ala 
    130                 135                 140                 


Cys Arg Thr Glu Val Arg Arg Leu Gly Gly Ile Leu Pro Leu Val Thr 
145                 150                 155                 160 


Ile Leu Gln Cys Met Lys Thr Asp Ser Ile Gln Asn Arg Thr Ala Arg 
                165                 170                 175     


Ala Leu Gly Asn Leu Ala Met Glu Pro Glu Ser Cys Gly Asp Ile His 
            180                 185                 190         


Cys Ala Gly Ala Val Pro Leu Leu Val Glu Ser Leu Thr Ala Cys Gln 
        195                 200                 205             


Asp Ser Gln Cys Leu Gln Ser Val Val Arg Ala Leu Arg Asn Leu Ala 
    210                 215                 220                 


Asp Ser Pro Gln His Arg Leu Ala Leu Ala Gln Gln Gly Ala Val Arg 
225                 230                 235                 240 


Pro Leu Ala Glu Leu Leu Ala Thr Ala Pro Asp Ala Ala Leu Thr Leu 
                245                 250                 255     


Ala Leu Val Arg Ala Leu Leu Glu Leu Ser Arg Gly Cys Ser Arg Ala 
            260                 265                 270         


Cys Ala Glu Gln Leu Ser Leu Gly Gly Gly Leu Gly Pro Leu Val Ser 
        275                 280                 285             


Leu Ala Ser His Pro Lys Arg Ala Val Arg Glu Gly Thr Ile Leu Ile 
    290                 295                 300                 


Leu Ala Asn Leu Cys Ala Gln Gly Leu Ile Arg Pro Ala Leu Gly Asn 
305                 310                 315                 320 


Ala Gly Gly Val Glu Val Leu Val Asp Glu Leu Arg Gln Arg Arg Asp 
                325                 330                 335     


Pro Asn Gly Ala Ser Pro Thr Ser Gln Gln Pro Leu Val Arg Ala Val 
            340                 345                 350         


Cys Leu Leu Cys Arg Glu Ala Ile Asn Arg Ala Arg Leu Arg Asp Ala 
        355                 360                 365             


Gly Gly Leu Asp Leu Leu Met Gly Leu Leu Arg Asp Pro Arg Ala Ser 
    370                 375                 380                 


Ala Trp His Pro Arg Ile Val Ala Ala Leu Val Gly Phe Leu Tyr Asp 
385                 390                 395                 400 


Thr Gly Ala Leu Gly Arg Leu Gln Ala Leu Gly Leu Val Pro Leu Leu 
                405                 410                 415     


Ala Gly Gln Leu Cys Gly Glu Ala Gly Glu Glu Glu Glu Glu Gly Arg 
            420                 425                 430         


Glu Ala Ala Ser Trp Asp Phe Pro Glu Glu Arg Thr Pro Glu Arg Ala 
        435                 440                 445             


Gln Gly Gly Ser Phe Arg Ser Leu Arg Ser Trp Leu Ile Ser Glu Gly 
    450                 455                 460                 


Tyr Ala Thr Gly Pro Asp Asp Ile Ser Pro Asp Trp Ser Pro Glu Gln 
465                 470                 475                 480 


Cys Pro Pro Glu Pro Met Glu Pro Ala Ser Pro Ala Pro Thr Pro Thr 
                485                 490                 495     


Ser Leu Arg Ala Pro Arg Thr Gln Arg Thr Pro Gly Arg Ser Pro Ala 
            500                 505                 510         


Ala Ala Ile Glu Glu Pro Trp Gly Arg Glu Gly Pro Ala Leu Leu Leu 
        515                 520                 525             


Leu Ser Arg Phe Ser Gln Ala Pro Asp Pro Ser Gly Ala Leu Val Thr 
    530                 535                 540                 


Gly Pro Ala Leu Tyr Gly Leu Leu Thr Tyr Val Thr Gly Ala Pro Gly 
545                 550                 555                 560 


Pro Pro Ser Pro Arg Ala Leu Arg Ile Leu Ser Arg Leu Thr Cys Asn 
                565                 570                 575     


Pro Ala Cys Leu Glu Ala Phe Val Arg Ser Tyr Gly Ala Ala Leu Leu 
            580                 585                 590         


Arg Ala Trp Leu Val Leu Gly Val Ala Pro Asp Asp Trp Pro Ala Pro 
        595                 600                 605             


Arg Ala Arg Pro Thr Leu His Ser Arg His Arg Glu Leu Gly Glu Arg 
    610                 615                 620                 


Leu Leu Gln Asn Leu Thr Val Gln Ala Glu Ser Pro Phe Gly Val Gly 
625                 630                 635                 640 


Ala Leu Thr His Leu Leu Leu Ser Gly Ser Pro Glu Asp Arg Val Ala 
                645                 650                 655     


Cys Ala Leu Thr Leu Pro Phe Ile Cys Arg Lys Pro Ser Leu Trp Arg 
            660                 665                 670         


Arg Leu Leu Leu Glu Gln Gly Gly Leu Arg Leu Leu Leu Ala Ala Leu 
        675                 680                 685             


Thr Arg Pro Ala Pro His Pro Leu Phe Leu Phe Phe Ala Ala Asp Ser 
    690                 695                 700                 


Leu Ser Cys Leu Gln Asp Leu Val Ser Pro Thr Val Ser Pro Ala Val 
705                 710                 715                 720 


Pro Gln Ala Val Pro Met Asp Leu Asp Ser Pro Ser Pro Cys Leu Tyr 
                725                 730                 735     


Glu Pro Leu Leu Gly Pro Ala Pro Val Pro Ala Pro Asp Leu His Phe 
            740                 745                 750         


Leu Leu Asp Ser Gly Leu Gln Leu Pro Ala Gln Arg Ala Ala Ser Ala 
        755                 760                 765             


Thr Ala Ser Pro Phe Phe Arg Ala Leu Leu Ser Gly Ser Phe Ala Glu 
    770                 775                 780                 


Ala Gln Met Asp Leu Val Pro Leu Arg Gly Leu Ser Pro Gly Ala Ala 
785                 790                 795                 800 


Trp Pro Val Leu His His Leu His Gly Cys Arg Gly Cys Gly Ala Ala 
                805                 810                 815     


Leu Gly Pro Val Pro Pro Pro Gly Gln Pro Leu Leu Gly Ser Glu Ala 
            820                 825                 830         


Glu Glu Ala Leu Glu Ala Ala Gly Arg Phe Leu Leu Pro Gly Leu Glu 
        835                 840                 845             


Glu Glu Leu Glu Glu Ala Val Gly Arg Ile His Leu Gly Pro Gln Gly 
    850                 855                 860                 


Gly Pro Glu Ser Val Gly Glu Val Phe Arg Leu Gly Arg Pro Arg Leu 
865                 870                 875                 880 


Ala Ala His Cys Ala Arg Trp Thr Leu Gly Ser Glu Gln Cys Pro Arg 
                885                 890                 895     


Lys Arg Gly Leu Ala Leu Val Gly Leu Val Glu Ala Ala Gly Glu Glu 
            900                 905                 910         


Ala Gly Pro Leu Thr Glu Ala Leu Leu Ala Val Val Met Gly Ile Glu 
        915                 920                 925             


Leu Gly Ala Arg Val Pro Ala 
    930                 935 


<210>  1071
<211>  725
<212>  PRT
<213>  Homo Sapiens

<400>  1071

Met Ala Ala Ala Lys Pro Thr Leu Thr Asp Ser Leu Ser Phe Cys Leu 
1               5                   10                  15      


Ala Gln Leu Ala Ala Ala Ala Gly Glu Ala Leu Gly Gly Glu Lys Asp 
            20                  25                  30          


Pro Ala Thr Asn Glu Thr Pro Leu Ser Arg Ala Leu Leu Ala Leu Arg 
        35                  40                  45              


Thr Arg His Ile Lys Ala Ala Gly Gly Ile Glu Arg Phe Arg Ala Arg 
    50                  55                  60                  


Gly Gly Leu Arg Pro Leu Leu Ala Leu Leu Arg Arg Ala Ala Ala Ala 
65                  70                  75                  80  


Gly Ser Ala Pro Ser Gln Ala Gly Pro Gly Ser Ala Pro Ser Ser Ala 
                85                  90                  95      


Ala Ser Gly Ala Ser Ser Pro Ala Pro Ala Ser Gly Pro Ala Pro Ser 
            100                 105                 110         


Ala Val Ser Ser Ser Ser Pro Thr Pro Pro Val Arg Leu Arg Lys Thr 
        115                 120                 125             


Leu Asp Leu Ala Leu Ser Ile Leu Ala Asp Cys Cys Thr Glu Gly Ala 
    130                 135                 140                 


Cys Arg Thr Glu Val Arg Arg Leu Gly Gly Ile Leu Pro Leu Val Thr 
145                 150                 155                 160 


Ile Leu Gln Cys Met Lys Thr Asp Ser Ile Gln Asn Arg Thr Ala Arg 
                165                 170                 175     


Ala Leu Gly Asn Leu Ala Met Glu Pro Glu Ser Cys Gly Asp Ile His 
            180                 185                 190         


Cys Ala Gly Ala Val Pro Leu Leu Val Glu Ser Leu Thr Ala Cys Gln 
        195                 200                 205             


Asp Ser Gln Cys Leu Gln Ser Val Val Arg Ala Leu Arg Asn Leu Ala 
    210                 215                 220                 


Asp Ser Pro Gln His Arg Leu Ala Leu Ala Gln Gln Gly Ala Val Arg 
225                 230                 235                 240 


Pro Leu Ala Glu Leu Leu Ala Thr Ala Pro Asp Ala Ala Leu Thr Leu 
                245                 250                 255     


Ala Leu Val Arg Ala Leu Leu Glu Leu Ser Arg Gly Cys Ser Arg Ala 
            260                 265                 270         


Cys Ala Glu Gln Leu Ser Leu Gly Gly Gly Leu Gly Pro Leu Val Ser 
        275                 280                 285             


Leu Ala Ser His Pro Lys Arg Ala Val Arg Glu Gly Thr Ile Leu Ile 
    290                 295                 300                 


Leu Ala Asn Leu Cys Ala Gln Gly Leu Ile Arg Pro Ala Leu Gly Asn 
305                 310                 315                 320 


Ala Gly Gly Val Glu Val Leu Val Asp Glu Leu Arg Gln Arg Arg Asp 
                325                 330                 335     


Pro Asn Gly Ala Ser Pro Thr Ser Gln Gln Pro Leu Val Arg Ala Val 
            340                 345                 350         


Cys Leu Leu Cys Arg Glu Ala Ile Asn Arg Ala Arg Leu Arg Asp Ala 
        355                 360                 365             


Gly Gly Leu Asp Leu Leu Met Gly Leu Leu Arg Asp Pro Arg Ala Ser 
    370                 375                 380                 


Ala Trp His Pro Arg Ile Val Ala Ala Leu Val Gly Phe Leu Tyr Asp 
385                 390                 395                 400 


Thr Gly Ala Leu Gly Arg Leu Gln Ala Leu Gly Leu Val Pro Leu Leu 
                405                 410                 415     


Ala Gly Gln Leu Cys Gly Glu Ala Gly Glu Glu Glu Glu Glu Gly Arg 
            420                 425                 430         


Glu Ala Ala Ser Trp Asp Phe Pro Glu Glu Arg Thr Pro Glu Arg Ala 
        435                 440                 445             


Gln Gly Gly Ser Phe Arg Ser Leu Arg Ser Trp Leu Ile Ser Glu Gly 
    450                 455                 460                 


Tyr Ala Thr Gly Pro Asp Asp Ile Ser Pro Asp Trp Ser Pro Glu Gln 
465                 470                 475                 480 


Cys Pro Pro Glu Pro Met Glu Pro Ala Ser Pro Ala Pro Thr Pro Thr 
                485                 490                 495     


Ser Leu Arg Ala Pro Arg Thr Gln Arg Thr Pro Gly Arg Ser Pro Ala 
            500                 505                 510         


Ala Ala Ile Glu Glu Pro Trp Gly Arg Glu Gly Pro Ala Leu Leu Leu 
        515                 520                 525             


Leu Ser Arg Phe Ser Gln Ala Pro Asp Pro Ser Gly Ala Leu Val Thr 
    530                 535                 540                 


Gly Pro Ala Leu Tyr Gly Leu Leu Thr Tyr Val Thr Gly Ala Pro Gly 
545                 550                 555                 560 


Pro Pro Ser Pro Arg Ala Leu Arg Ile Leu Ser Arg Leu Thr Cys Asn 
                565                 570                 575     


Pro Ala Cys Leu Glu Ala Phe Val Arg Ser Tyr Gly Ala Ala Leu Leu 
            580                 585                 590         


Arg Ala Trp Leu Val Leu Gly Val Ala Pro Asp Asp Trp Pro Ala Pro 
        595                 600                 605             


Arg Ala Arg Pro Thr Leu His Ser Arg His Arg Glu Leu Gly Glu Phe 
    610                 615                 620                 


Pro Tyr Pro Pro Val Ser Leu Pro Pro Cys Glu Ser Pro Ser Ser Pro 
625                 630                 635                 640 


Met Ala Ser Met Gly Pro Glu Pro His Leu Pro Thr His Leu Ser Ser 
                645                 650                 655     


Pro Ala Arg Pro Pro Asp Asn Leu Ser Pro Glu Trp Gly Gly Glu Gln 
            660                 665                 670         


Gly Val Pro Val Pro Pro Trp Ala His Arg Gln Ser Ser Ala Val Ser 
        675                 680                 685             


Ser Ala Leu Ala Leu Gly Pro Arg Tyr Pro Asn Ser Arg Cys Ser Pro 
    690                 695                 700                 


Ala Pro Arg Ile Trp Ala Gly Leu Cys Phe Phe Pro Gly Ser Ala Ile 
705                 710                 715                 720 


Gly Ser Ala Leu Ser 
                725 


<210>  1072
<211>  771
<212>  PRT
<213>  Homo Sapiens

<400>  1072

Met Lys Thr Asp Ser Ile Gln Asn Arg Thr Ala Arg Ala Leu Gly Asn 
1               5                   10                  15      


Leu Ala Met Glu Pro Glu Ser Cys Gly Asp Ile His Cys Ala Gly Ala 
            20                  25                  30          


Val Pro Leu Leu Val Glu Ser Leu Thr Ala Cys Gln Asp Ser Gln Cys 
        35                  40                  45              


Leu Gln Ser Val Val Arg Ala Leu Arg Asn Leu Ala Asp Ser Pro Gln 
    50                  55                  60                  


His Arg Leu Ala Leu Ala Gln Gln Gly Ala Val Arg Pro Leu Ala Glu 
65                  70                  75                  80  


Leu Leu Ala Thr Ala Pro Asp Ala Ala Leu Thr Leu Ala Leu Val Arg 
                85                  90                  95      


Ala Leu Leu Glu Leu Ser Arg Gly Cys Ser Arg Ala Cys Ala Glu Gln 
            100                 105                 110         


Leu Ser Leu Gly Gly Gly Leu Gly Pro Leu Val Ser Leu Ala Ser His 
        115                 120                 125             


Pro Lys Arg Ala Val Arg Glu Gly Thr Ile Leu Ile Leu Ala Asn Leu 
    130                 135                 140                 


Cys Ala Gln Gly Leu Ile Arg Pro Ala Leu Gly Asn Ala Gly Gly Val 
145                 150                 155                 160 


Glu Val Leu Val Asp Glu Leu Arg Gln Arg Arg Asp Pro Asn Gly Ala 
                165                 170                 175     


Ser Pro Thr Ser Gln Gln Pro Leu Val Arg Ala Val Cys Leu Leu Cys 
            180                 185                 190         


Arg Glu Ala Ile Asn Arg Ala Arg Leu Arg Asp Ala Gly Gly Leu Asp 
        195                 200                 205             


Leu Leu Met Gly Leu Leu Arg Asp Pro Arg Ala Ser Ala Trp His Pro 
    210                 215                 220                 


Arg Ile Val Ala Ala Leu Val Gly Phe Leu Tyr Asp Thr Gly Ala Leu 
225                 230                 235                 240 


Gly Arg Leu Gln Ala Leu Gly Leu Val Pro Leu Leu Ala Gly Gln Leu 
                245                 250                 255     


Cys Gly Glu Ala Gly Glu Glu Glu Glu Glu Gly Arg Glu Ala Ala Ser 
            260                 265                 270         


Trp Asp Phe Pro Glu Glu Arg Thr Pro Glu Arg Ala Gln Gly Gly Ser 
        275                 280                 285             


Phe Arg Ser Leu Arg Ser Trp Leu Ile Ser Glu Gly Tyr Ala Thr Gly 
    290                 295                 300                 


Pro Asp Asp Ile Ser Pro Asp Trp Ser Pro Glu Gln Cys Pro Pro Glu 
305                 310                 315                 320 


Pro Met Glu Pro Ala Ser Pro Ala Pro Thr Pro Thr Ser Leu Arg Ala 
                325                 330                 335     


Pro Arg Thr Gln Arg Thr Pro Gly Arg Ser Pro Ala Ala Ala Ile Glu 
            340                 345                 350         


Glu Pro Trp Gly Arg Glu Gly Pro Ala Leu Leu Leu Leu Ser Arg Phe 
        355                 360                 365             


Ser Gln Ala Pro Asp Pro Ser Gly Ala Leu Val Thr Gly Pro Ala Leu 
    370                 375                 380                 


Tyr Gly Leu Leu Thr Tyr Val Thr Gly Ala Pro Gly Pro Pro Ser Pro 
385                 390                 395                 400 


Arg Ala Leu Arg Ile Leu Ser Arg Leu Thr Cys Asn Pro Ala Cys Leu 
                405                 410                 415     


Glu Ala Phe Val Arg Ser Tyr Gly Ala Ala Leu Leu Arg Ala Trp Leu 
            420                 425                 430         


Val Leu Gly Val Ala Pro Asp Asp Trp Pro Ala Pro Arg Ala Arg Pro 
        435                 440                 445             


Thr Leu His Ser Arg His Arg Glu Leu Gly Glu Arg Leu Leu Gln Asn 
    450                 455                 460                 


Leu Thr Val Gln Ala Glu Ser Pro Phe Gly Val Gly Ala Leu Thr His 
465                 470                 475                 480 


Leu Leu Leu Ser Gly Ser Pro Glu Asp Arg Val Ala Cys Ala Leu Thr 
                485                 490                 495     


Leu Pro Phe Ile Cys Arg Lys Pro Ser Leu Trp Arg Arg Leu Leu Leu 
            500                 505                 510         


Glu Gln Gly Gly Leu Arg Leu Leu Leu Ala Ala Leu Thr Arg Pro Ala 
        515                 520                 525             


Pro His Pro Leu Phe Leu Phe Phe Ala Ala Asp Ser Leu Ser Cys Leu 
    530                 535                 540                 


Gln Asp Leu Val Ser Pro Thr Val Ser Pro Ala Val Pro Gln Ala Val 
545                 550                 555                 560 


Pro Met Asp Leu Asp Ser Pro Ser Pro Cys Leu Tyr Glu Pro Leu Leu 
                565                 570                 575     


Gly Pro Ala Pro Val Pro Ala Pro Asp Leu His Phe Leu Leu Asp Ser 
            580                 585                 590         


Gly Leu Gln Leu Pro Ala Gln Arg Ala Ala Ser Ala Thr Ala Ser Pro 
        595                 600                 605             


Phe Phe Arg Ala Leu Leu Ser Gly Ser Phe Ala Glu Ala Gln Met Asp 
    610                 615                 620                 


Leu Val Pro Leu Arg Gly Leu Ser Pro Gly Ala Ala Trp Pro Val Leu 
625                 630                 635                 640 


His His Leu His Gly Cys Arg Gly Cys Gly Ala Ala Leu Gly Pro Val 
                645                 650                 655     


Pro Pro Pro Gly Gln Pro Leu Leu Gly Ser Glu Ala Glu Glu Ala Leu 
            660                 665                 670         


Glu Ala Ala Gly Arg Phe Leu Leu Pro Gly Leu Glu Glu Glu Leu Glu 
        675                 680                 685             


Glu Ala Val Gly Arg Ile His Leu Gly Pro Gln Gly Gly Pro Glu Ser 
    690                 695                 700                 


Val Gly Glu Val Phe Arg Leu Gly Arg Pro Arg Leu Ala Ala His Cys 
705                 710                 715                 720 


Ala Arg Trp Thr Leu Gly Ser Glu Gln Cys Pro Arg Lys Arg Gly Leu 
                725                 730                 735     


Ala Leu Val Gly Leu Val Glu Ala Ala Gly Glu Glu Ala Gly Pro Leu 
            740                 745                 750         


Thr Glu Ala Leu Leu Ala Val Val Met Gly Ile Glu Leu Gly Ala Arg 
        755                 760                 765             


Val Pro Ala 
    770     


<210>  1073
<211>  1030
<212>  PRT
<213>  Homo Sapiens

<400>  1073

Met Val Thr Leu Gly Ala Gly Val Arg Leu Phe Thr Gly Val Tyr Pro 
1               5                   10                  15      


Val Val Leu Asn Gln Ile Arg Ala Thr Ser Glu Ala Ser Ala Ile Thr 
            20                  25                  30          


Arg Thr Thr Met Pro Ala Pro Glu Leu Thr Ser Thr Ser Arg Ala Glu 
        35                  40                  45              


Asp Thr Arg Asp Thr Gly Val Gln Leu Arg Lys Arg Lys Ile Pro Gln 
    50                  55                  60                  


Ala Arg His Ser Arg Lys Arg Gln Arg Thr Phe Ser Phe Arg Ser Leu 
65                  70                  75                  80  


Gly Ser Ala Ala Arg Ser Gly Ala Glu Ser Glu Ala Arg Ala Lys Met 
                85                  90                  95      


Ala Ala Ala Lys Pro Thr Leu Thr Asp Ser Leu Ser Phe Cys Leu Ala 
            100                 105                 110         


Gln Leu Ala Ala Ala Ala Gly Glu Ala Leu Gly Gly Glu Lys Asp Pro 
        115                 120                 125             


Ala Thr Asn Glu Thr Pro Leu Ser Arg Ala Leu Leu Ala Leu Arg Thr 
    130                 135                 140                 


Arg His Ile Lys Ala Ala Gly Gly Ile Glu Arg Phe Arg Ala Arg Gly 
145                 150                 155                 160 


Gly Leu Arg Pro Leu Leu Ala Leu Leu Arg Arg Ala Ala Ala Ala Gly 
                165                 170                 175     


Ser Ala Pro Ser Gln Ala Gly Pro Gly Ser Ala Pro Ser Ser Ala Ala 
            180                 185                 190         


Ser Gly Ala Ser Ser Pro Ala Pro Ala Ser Gly Pro Ala Pro Ser Ala 
        195                 200                 205             


Val Ser Ser Ser Ser Pro Thr Pro Pro Val Arg Leu Arg Lys Thr Leu 
    210                 215                 220                 


Asp Leu Ala Leu Ser Ile Leu Ala Asp Cys Cys Thr Glu Gly Ala Cys 
225                 230                 235                 240 


Arg Thr Glu Val Arg Arg Leu Gly Gly Ile Leu Pro Leu Val Thr Ile 
                245                 250                 255     


Leu Gln Cys Met Lys Thr Asp Ser Ile Gln Asn Arg Thr Ala Arg Ala 
            260                 265                 270         


Leu Gly Asn Leu Ala Met Glu Pro Glu Ser Cys Gly Asp Ile His Cys 
        275                 280                 285             


Ala Gly Ala Val Pro Leu Leu Val Glu Ser Leu Thr Ala Cys Gln Asp 
    290                 295                 300                 


Ser Gln Cys Leu Gln Ser Val Val Arg Ala Leu Arg Asn Leu Ala Asp 
305                 310                 315                 320 


Ser Pro Gln His Arg Leu Ala Leu Ala Gln Gln Gly Ala Val Arg Pro 
                325                 330                 335     


Leu Ala Glu Leu Leu Ala Thr Ala Pro Asp Ala Ala Leu Thr Leu Ala 
            340                 345                 350         


Leu Val Arg Ala Leu Leu Glu Leu Ser Arg Gly Cys Ser Arg Ala Cys 
        355                 360                 365             


Ala Glu Gln Leu Ser Leu Gly Gly Gly Leu Gly Pro Leu Val Ser Leu 
    370                 375                 380                 


Ala Ser His Pro Lys Arg Ala Val Arg Glu Gly Thr Ile Leu Ile Leu 
385                 390                 395                 400 


Ala Asn Leu Cys Ala Gln Gly Leu Ile Arg Pro Ala Leu Gly Asn Ala 
                405                 410                 415     


Gly Gly Val Glu Val Leu Val Asp Glu Leu Arg Gln Arg Arg Asp Pro 
            420                 425                 430         


Asn Gly Ala Ser Pro Thr Ser Gln Gln Pro Leu Val Arg Ala Val Cys 
        435                 440                 445             


Leu Leu Cys Arg Glu Ala Ile Asn Arg Ala Arg Leu Arg Asp Ala Gly 
    450                 455                 460                 


Gly Leu Asp Leu Leu Met Gly Leu Leu Arg Asp Pro Arg Ala Ser Ala 
465                 470                 475                 480 


Trp His Pro Arg Ile Val Ala Ala Leu Val Gly Phe Leu Tyr Asp Thr 
                485                 490                 495     


Gly Ala Leu Gly Arg Leu Gln Ala Leu Gly Leu Val Pro Leu Leu Ala 
            500                 505                 510         


Gly Gln Leu Cys Gly Glu Ala Gly Glu Glu Glu Glu Glu Gly Arg Glu 
        515                 520                 525             


Ala Ala Ser Trp Asp Phe Pro Glu Glu Arg Thr Pro Glu Arg Ala Gln 
    530                 535                 540                 


Gly Gly Ser Phe Arg Ser Leu Arg Ser Trp Leu Ile Ser Glu Gly Tyr 
545                 550                 555                 560 


Ala Thr Gly Pro Asp Asp Ile Ser Pro Asp Trp Ser Pro Glu Gln Cys 
                565                 570                 575     


Pro Pro Glu Pro Met Glu Pro Ala Ser Pro Ala Pro Thr Pro Thr Ser 
            580                 585                 590         


Leu Arg Ala Pro Arg Thr Gln Arg Thr Pro Gly Arg Ser Pro Ala Ala 
        595                 600                 605             


Ala Ile Glu Glu Pro Trp Gly Arg Glu Gly Pro Ala Leu Leu Leu Leu 
    610                 615                 620                 


Ser Arg Phe Ser Gln Ala Pro Asp Pro Ser Gly Ala Leu Val Thr Gly 
625                 630                 635                 640 


Pro Ala Leu Tyr Gly Leu Leu Thr Tyr Val Thr Gly Ala Pro Gly Pro 
                645                 650                 655     


Pro Ser Pro Arg Ala Leu Arg Ile Leu Ser Arg Leu Thr Cys Asn Pro 
            660                 665                 670         


Ala Cys Leu Glu Ala Phe Val Arg Ser Tyr Gly Ala Ala Leu Leu Arg 
        675                 680                 685             


Ala Trp Leu Val Leu Gly Val Ala Pro Asp Asp Trp Pro Ala Pro Arg 
    690                 695                 700                 


Ala Arg Pro Thr Leu His Ser Arg His Arg Glu Leu Gly Glu Arg Leu 
705                 710                 715                 720 


Leu Gln Asn Leu Thr Val Gln Ala Glu Ser Pro Phe Gly Val Gly Ala 
                725                 730                 735     


Leu Thr His Leu Leu Leu Ser Gly Ser Pro Glu Asp Arg Val Ala Cys 
            740                 745                 750         


Ala Leu Thr Leu Pro Phe Ile Cys Arg Lys Pro Ser Leu Trp Arg Arg 
        755                 760                 765             


Leu Leu Leu Glu Gln Gly Gly Leu Arg Leu Leu Leu Ala Ala Leu Thr 
    770                 775                 780                 


Arg Pro Ala Pro His Pro Leu Phe Leu Phe Phe Ala Ala Asp Ser Leu 
785                 790                 795                 800 


Ser Cys Leu Gln Asp Leu Val Ser Pro Thr Val Ser Pro Ala Val Pro 
                805                 810                 815     


Gln Ala Val Pro Met Asp Leu Asp Ser Pro Ser Pro Cys Leu Tyr Glu 
            820                 825                 830         


Pro Leu Leu Gly Pro Ala Pro Val Pro Ala Pro Asp Leu His Phe Leu 
        835                 840                 845             


Leu Asp Ser Gly Leu Gln Leu Pro Ala Gln Arg Ala Ala Ser Ala Thr 
    850                 855                 860                 


Ala Ser Pro Phe Phe Arg Ala Leu Leu Ser Gly Ser Phe Ala Glu Ala 
865                 870                 875                 880 


Gln Met Asp Leu Val Pro Leu Arg Gly Leu Ser Pro Gly Ala Ala Trp 
                885                 890                 895     


Pro Val Leu His His Leu His Gly Cys Arg Gly Cys Gly Ala Ala Leu 
            900                 905                 910         


Gly Pro Val Pro Pro Pro Gly Gln Pro Leu Leu Gly Ser Glu Ala Glu 
        915                 920                 925             


Glu Ala Leu Glu Ala Ala Gly Arg Phe Leu Leu Pro Gly Leu Glu Glu 
    930                 935                 940                 


Glu Leu Glu Glu Ala Val Gly Arg Ile His Leu Gly Pro Gln Gly Gly 
945                 950                 955                 960 


Pro Glu Ser Val Gly Glu Val Phe Arg Leu Gly Arg Pro Arg Leu Ala 
                965                 970                 975     


Ala His Cys Ala Arg Trp Thr Leu Gly Ser Glu Gln Cys Pro Arg Lys 
            980                 985                 990         


Arg Gly Leu Ala Leu Val Gly Leu  Val Glu Ala Ala Gly  Glu Glu Ala 
        995                 1000                 1005             


Gly Pro  Leu Thr Glu Ala Leu  Leu Ala Val Val Met  Gly Ile Glu 
    1010                 1015                 1020             


Leu Gly  Ala Arg Val Pro Ala  
    1025                 1030 


<210>  1074
<211>  10
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1074

Xaa Leu Gly Lys Cys Ser Ala Pro Val Ser 
1               5                   10  


<210>  1075
<211>  598
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1075

Xaa Thr Glu Val Arg Arg Leu Gly Gly Ile Leu Pro Leu Val Thr Ile 
1               5                   10                  15      


Leu Gln Cys Met Lys Thr Asp Ser Ile Gln Asn Arg Thr Ala Arg Ala 
            20                  25                  30          


Leu Gly Asn Leu Ala Met Glu Pro Glu Ser Cys Gly Asp Ile His Cys 
        35                  40                  45              


Ala Gly Ala Val Pro Leu Leu Val Glu Ser Leu Thr Ala Cys Gln Asp 
    50                  55                  60                  


Ser Gln Cys Leu Gln Ser Val Ala Leu Gly Leu Val Pro Leu Leu Ala 
65                  70                  75                  80  


Gly Gln Leu Cys Gly Glu Ala Gly Glu Glu Glu Glu Glu Gly Arg Glu 
                85                  90                  95      


Ala Ala Ser Trp Asp Phe Pro Glu Glu Arg Thr Pro Glu Arg Ala Gln 
            100                 105                 110         


Gly Gly Ser Phe Arg Ser Leu Arg Ser Trp Leu Ile Ser Glu Gly Tyr 
        115                 120                 125             


Ala Thr Gly Pro Asp Asp Ile Ser Pro Asp Trp Ser Pro Glu Gln Cys 
    130                 135                 140                 


Pro Pro Glu Pro Met Glu Pro Ala Ser Pro Ala Pro Thr Pro Thr Ser 
145                 150                 155                 160 


Leu Arg Ala Pro Arg Thr Gln Arg Thr Pro Gly Arg Ser Pro Ala Ala 
                165                 170                 175     


Ala Ile Glu Glu Pro Trp Gly Arg Glu Gly Pro Ala Leu Leu Leu Leu 
            180                 185                 190         


Ser Arg Phe Ser Gln Ala Pro Asp Pro Ser Gly Ala Leu Val Thr Gly 
        195                 200                 205             


Pro Ala Leu Tyr Gly Leu Leu Thr Tyr Val Thr Gly Ala Pro Gly Pro 
    210                 215                 220                 


Pro Ser Pro Arg Ala Leu Arg Ile Leu Ser Arg Leu Thr Cys Asn Pro 
225                 230                 235                 240 


Ala Cys Leu Glu Ala Phe Val Arg Ser Tyr Gly Ala Ala Leu Leu Arg 
                245                 250                 255     


Ala Trp Leu Val Leu Gly Val Ala Pro Asp Asp Trp Pro Ala Pro Arg 
            260                 265                 270         


Ala Arg Pro Thr Leu His Ser Arg His Arg Glu Leu Gly Glu Arg Leu 
        275                 280                 285             


Leu Gln Asn Leu Thr Val Gln Ala Glu Ser Pro Phe Gly Val Gly Ala 
    290                 295                 300                 


Leu Thr His Leu Leu Leu Ser Gly Ser Pro Glu Asp Arg Val Ala Cys 
305                 310                 315                 320 


Ala Leu Thr Leu Pro Phe Ile Cys Arg Lys Pro Ser Leu Trp Arg Arg 
                325                 330                 335     


Leu Leu Leu Glu Gln Gly Gly Leu Arg Leu Leu Leu Ala Ala Leu Thr 
            340                 345                 350         


Arg Pro Ala Pro His Pro Leu Phe Leu Phe Phe Ala Ala Asp Ser Leu 
        355                 360                 365             


Ser Cys Leu Gln Asp Leu Val Ser Pro Thr Val Ser Pro Ala Val Pro 
    370                 375                 380                 


Gln Ala Val Pro Met Asp Leu Asp Ser Pro Ser Pro Cys Leu Tyr Glu 
385                 390                 395                 400 


Pro Leu Leu Gly Pro Ala Pro Val Pro Ala Pro Asp Leu His Phe Leu 
                405                 410                 415     


Leu Asp Ser Gly Leu Gln Leu Pro Ala Gln Arg Ala Ala Ser Ala Thr 
            420                 425                 430         


Ala Ser Pro Phe Phe Arg Ala Leu Leu Ser Gly Ser Phe Ala Glu Ala 
        435                 440                 445             


Gln Met Asp Leu Val Pro Leu Arg Gly Leu Ser Pro Gly Ala Ala Trp 
    450                 455                 460                 


Pro Val Leu His His Leu His Gly Cys Arg Gly Cys Gly Ala Ala Leu 
465                 470                 475                 480 


Gly Pro Val Pro Pro Pro Gly Gln Pro Leu Leu Gly Ser Glu Ala Glu 
                485                 490                 495     


Glu Ala Leu Glu Ala Ala Gly Arg Phe Leu Leu Pro Gly Leu Glu Glu 
            500                 505                 510         


Glu Leu Glu Glu Ala Val Gly Arg Ile His Leu Gly Pro Gln Gly Gly 
        515                 520                 525             


Pro Glu Ser Val Gly Glu Val Phe Arg Leu Gly Arg Pro Arg Leu Ala 
    530                 535                 540                 


Ala His Cys Ala Arg Trp Thr Leu Gly Ser Glu Gln Cys Pro Arg Lys 
545                 550                 555                 560 


Arg Gly Leu Ala Leu Val Gly Leu Val Glu Ala Ala Gly Glu Glu Ala 
                565                 570                 575     


Gly Pro Leu Thr Glu Ala Leu Leu Ala Val Val Met Gly Ile Glu Leu 
            580                 585                 590         


Gly Ala Arg Val Pro Ala 
        595             


<210>  1076
<211>  23
<212>  PRT
<213>  Homo Sapiens

<400>  1076

Met Ala Asp Gln Arg Met Asp Ile Ser Ser Thr Ile Ser Asp Phe Met 
1               5                   10                  15      


Ser Pro Gly Pro Thr Asp Leu 
            20              


<210>  1077
<211>  59
<212>  PRT
<213>  Homo Sapiens

<400>  1077

Met Ala Asp Gln Arg Met Asp Ile Ser Ser Thr Ile Ser Asp Phe Met 
1               5                   10                  15      


Ser Pro Gly Pro Thr Asp Leu Leu Ser Ser Ser Leu Gly Thr Ser Gly 
            20                  25                  30          


Val Asp Cys Asn Arg Lys Arg Lys Gly Ser Ser Thr Asp Tyr Gln Glu 
        35                  40                  45              


Ser Met Asp Thr Asp Lys Asp Asp Pro His Gly 
    50                  55                  


<210>  1078
<211>  76
<212>  PRT
<213>  Homo Sapiens

<400>  1078

Met Ala Asp Gln Arg Met Asp Ile Ser Ser Thr Ile Ser Asp Phe Met 
1               5                   10                  15      


Ser Pro Gly Pro Thr Asp Leu Leu Ser Ser Ser Leu Gly Thr Ser Gly 
            20                  25                  30          


Val Asp Cys Asn Arg Lys Arg Lys Gly Ser Ser Thr Asp Tyr Gln Glu 
        35                  40                  45              


Ser Met Asp Thr Asp Lys Asp Asp Pro His Gly Arg Leu Glu Tyr Thr 
    50                  55                  60                  


Glu His Gln Gly Arg Ile Lys Asn Ala Arg Glu Ala 
65                  70                  75      


<210>  1079
<211>  101
<212>  PRT
<213>  Homo Sapiens

<400>  1079

Met Ala Asp Gln Arg Met Asp Ile Ser Ser Thr Ile Ser Asp Phe Met 
1               5                   10                  15      


Ser Pro Gly Pro Thr Asp Leu Leu Ser Ser Ser Leu Gly Thr Ser Gly 
            20                  25                  30          


Val Asp Cys Asn Arg Lys Arg Lys Gly Ser Ser Thr Asp Tyr Gln Glu 
        35                  40                  45              


Ser Met Asp Thr Asp Lys Asp Asp Pro His Gly Arg Leu Glu Tyr Thr 
    50                  55                  60                  


Glu His Gln Gly Arg Ile Lys Asn Ala Arg Glu Ala His Ser Gln Ile 
65                  70                  75                  80  


Glu Lys Arg Arg Arg Asp Lys Met Asn Ser Phe Ile Asp Glu Leu Ala 
                85                  90                  95      


Ser Leu Val Pro Thr 
            100     


<210>  1080
<211>  135
<212>  PRT
<213>  Homo Sapiens

<400>  1080

Met Ala Asp Gln Arg Met Asp Ile Ser Ser Thr Ile Ser Asp Phe Met 
1               5                   10                  15      


Ser Pro Gly Pro Thr Asp Leu Leu Ser Ser Ser Leu Gly Thr Ser Gly 
            20                  25                  30          


Val Asp Cys Asn Arg Lys Arg Lys Gly Ser Ser Thr Asp Tyr Gln Glu 
        35                  40                  45              


Ser Met Asp Thr Asp Lys Asp Asp Pro His Gly Arg Leu Glu Tyr Thr 
    50                  55                  60                  


Glu His Gln Gly Arg Ile Lys Asn Ala Arg Glu Ala His Ser Gln Ile 
65                  70                  75                  80  


Glu Lys Arg Arg Arg Asp Lys Met Asn Ser Phe Ile Asp Glu Leu Ala 
                85                  90                  95      


Ser Leu Val Pro Thr Cys Asn Ala Met Ser Arg Lys Leu Asp Lys Leu 
            100                 105                 110         


Thr Val Leu Arg Met Ala Val Gln His Met Lys Thr Leu Arg Gly Ala 
        115                 120                 125             


Thr Asn Pro Tyr Thr Glu Ala 
    130                 135 


<210>  1081
<211>  626
<212>  PRT
<213>  Homo Sapiens

<400>  1081

Met Ala Asp Gln Arg Met Asp Ile Ser Ser Thr Ile Ser Asp Phe Met 
1               5                   10                  15      


Ser Pro Gly Pro Thr Asp Leu Leu Ser Ser Ser Leu Gly Thr Ser Gly 
            20                  25                  30          


Val Asp Cys Asn Arg Lys Arg Lys Gly Ser Ser Thr Asp Tyr Gln Glu 
        35                  40                  45              


Ser Met Asp Thr Asp Lys Asp Asp Pro His Gly Arg Leu Glu Tyr Thr 
    50                  55                  60                  


Glu His Gln Gly Arg Ile Lys Asn Ala Arg Glu Ala His Ser Gln Ile 
65                  70                  75                  80  


Glu Lys Arg Arg Arg Asp Lys Met Asn Ser Phe Ile Asp Glu Leu Ala 
                85                  90                  95      


Ser Leu Val Pro Thr Cys Asn Ala Met Ser Arg Lys Leu Asp Lys Leu 
            100                 105                 110         


Thr Val Leu Arg Met Ala Val Gln His Met Lys Thr Leu Arg Gly Ala 
        115                 120                 125             


Thr Asn Pro Tyr Thr Glu Ala Asn Tyr Lys Pro Thr Phe Leu Ser Asp 
    130                 135                 140                 


Asp Glu Leu Lys His Leu Ile Leu Arg Ala Ala Asp Gly Phe Leu Phe 
145                 150                 155                 160 


Val Val Gly Cys Asp Arg Gly Lys Ile Leu Phe Val Ser Glu Ser Val 
                165                 170                 175     


Phe Lys Ile Leu Asn Tyr Ser Gln Asn Asp Leu Ile Gly Gln Ser Leu 
            180                 185                 190         


Phe Asp Tyr Leu His Pro Lys Asp Ile Ala Lys Val Lys Glu Gln Leu 
        195                 200                 205             


Ser Ser Ser Asp Thr Ala Pro Arg Glu Arg Leu Ile Asp Ala Lys Thr 
    210                 215                 220                 


Gly Leu Pro Val Lys Thr Asp Ile Thr Pro Gly Pro Ser Arg Leu Cys 
225                 230                 235                 240 


Ser Gly Ala Arg Arg Ser Phe Phe Cys Arg Met Lys Cys Asn Arg Pro 
                245                 250                 255     


Ser Val Lys Val Glu Asp Lys Asp Phe Pro Ser Thr Cys Ser Lys Lys 
            260                 265                 270         


Lys Ala Asp Arg Lys Ser Phe Cys Thr Ile His Ser Thr Gly Tyr Leu 
        275                 280                 285             


Lys Ser Trp Pro Pro Thr Lys Met Gly Leu Asp Glu Asp Asn Glu Pro 
    290                 295                 300                 


Asp Asn Glu Gly Cys Asn Leu Ser Cys Leu Val Ala Ile Gly Arg Leu 
305                 310                 315                 320 


His Ser His Val Val Pro Gln Pro Val Asn Gly Glu Ile Arg Val Lys 
                325                 330                 335     


Ser Met Glu Tyr Val Ser Arg His Ala Ile Asp Gly Lys Phe Val Phe 
            340                 345                 350         


Val Asp Gln Arg Ala Thr Ala Ile Leu Ala Tyr Leu Pro Gln Glu Leu 
        355                 360                 365             


Leu Gly Thr Ser Cys Tyr Glu Tyr Phe His Gln Asp Asp Ile Gly His 
    370                 375                 380                 


Leu Ala Glu Cys His Arg Gln Val Leu Gln Thr Arg Glu Lys Ile Thr 
385                 390                 395                 400 


Thr Asn Cys Tyr Lys Phe Lys Ile Lys Asp Gly Ser Phe Ile Thr Leu 
                405                 410                 415     


Arg Ser Arg Trp Phe Ser Phe Met Asn Pro Trp Thr Lys Glu Val Glu 
            420                 425                 430         


Tyr Ile Val Ser Thr Asn Thr Val Val Leu Ala Asn Val Leu Glu Gly 
        435                 440                 445             


Gly Asp Pro Thr Phe Pro Gln Leu Thr Ala Ser Pro His Ser Met Asp 
    450                 455                 460                 


Ser Met Leu Pro Ser Gly Glu Gly Gly Pro Lys Arg Thr His Pro Thr 
465                 470                 475                 480 


Val Pro Gly Ile Pro Gly Gly Thr Arg Ala Gly Ala Gly Lys Ile Gly 
                485                 490                 495     


Arg Met Ile Ala Glu Glu Ile Met Glu Ile His Arg Ile Arg Gly Ser 
            500                 505                 510         


Ser Pro Ser Ser Cys Gly Ser Ser Pro Leu Asn Ile Thr Ser Thr Pro 
        515                 520                 525             


Pro Pro Asp Ala Ser Ser Pro Gly Gly Lys Lys Ile Leu Asn Gly Gly 
    530                 535                 540                 


Thr Pro Asp Ile Pro Ser Ser Gly Leu Leu Ser Gly Gln Ala Gln Glu 
545                 550                 555                 560 


Asn Pro Gly Tyr Pro Tyr Ser Asp Ser Ser Ser Ile Leu Gly Glu Asn 
                565                 570                 575     


Pro His Ile Gly Ile Asp Met Ile Asp Asn Asp Gln Gly Ser Ser Ser 
            580                 585                 590         


Pro Ser Asn Asp Glu Ala Ala Met Ala Val Ile Met Ser Leu Leu Glu 
        595                 600                 605             


Ala Asp Ala Gly Leu Gly Gly Pro Val Asp Phe Ser Asp Leu Pro Trp 
    610                 615                 620                 


Pro Leu 
625     


<210>  1082
<211>  625
<212>  PRT
<213>  Homo Sapiens

<400>  1082

Met Ala Asp Gln Arg Met Asp Ile Ser Ser Thr Ile Ser Asp Phe Met 
1               5                   10                  15      


Ser Pro Gly Pro Thr Asp Leu Leu Ser Ser Ser Leu Gly Thr Ser Gly 
            20                  25                  30          


Val Asp Cys Asn Arg Lys Arg Lys Gly Ser Ser Thr Asp Tyr Gln Glu 
        35                  40                  45              


Ser Met Asp Thr Asp Lys Asp Asp Pro His Gly Arg Leu Glu Tyr Thr 
    50                  55                  60                  


Glu His Gln Gly Arg Ile Lys Asn Ala Arg Glu Ala His Ser Gln Ile 
65                  70                  75                  80  


Glu Lys Arg Arg Arg Asp Lys Met Asn Ser Phe Ile Asp Glu Leu Ala 
                85                  90                  95      


Ser Leu Val Pro Thr Cys Asn Ala Met Ser Arg Lys Leu Asp Lys Leu 
            100                 105                 110         


Thr Val Leu Arg Met Ala Val Gln His Met Lys Thr Leu Arg Gly Ala 
        115                 120                 125             


Thr Asn Pro Tyr Thr Glu Ala Asn Tyr Lys Pro Thr Phe Leu Ser Asp 
    130                 135                 140                 


Asp Glu Leu Lys His Leu Ile Leu Arg Ala Ala Asp Gly Phe Leu Phe 
145                 150                 155                 160 


Val Val Gly Cys Asp Arg Gly Lys Ile Leu Phe Val Ser Glu Ser Val 
                165                 170                 175     


Phe Lys Ile Leu Asn Tyr Ser Gln Asn Asp Leu Ile Gly Gln Ser Leu 
            180                 185                 190         


Phe Asp Tyr Leu His Pro Lys Asp Ile Ala Lys Val Lys Glu Gln Leu 
        195                 200                 205             


Ser Ser Ser Asp Thr Ala Pro Arg Glu Arg Leu Ile Asp Ala Lys Thr 
    210                 215                 220                 


Gly Leu Pro Val Lys Thr Asp Ile Thr Pro Gly Pro Ser Arg Leu Cys 
225                 230                 235                 240 


Ser Gly Ala Arg Arg Ser Phe Phe Cys Arg Met Lys Cys Asn Arg Pro 
                245                 250                 255     


Ser Val Lys Val Glu Asp Lys Asp Phe Pro Ser Thr Cys Ser Lys Lys 
            260                 265                 270         


Lys Asp Arg Lys Ser Phe Cys Thr Ile His Ser Thr Gly Tyr Leu Lys 
        275                 280                 285             


Ser Trp Pro Pro Thr Lys Met Gly Leu Asp Glu Asp Asn Glu Pro Asp 
    290                 295                 300                 


Asn Glu Gly Cys Asn Leu Ser Cys Leu Val Ala Ile Gly Arg Leu His 
305                 310                 315                 320 


Ser His Val Val Pro Gln Pro Val Asn Gly Glu Ile Arg Val Lys Ser 
                325                 330                 335     


Met Glu Tyr Val Ser Arg His Ala Ile Asp Gly Lys Phe Val Phe Val 
            340                 345                 350         


Asp Gln Arg Ala Thr Ala Ile Leu Ala Tyr Leu Pro Gln Glu Leu Leu 
        355                 360                 365             


Gly Thr Ser Cys Tyr Glu Tyr Phe His Gln Asp Asp Ile Gly His Leu 
    370                 375                 380                 


Ala Glu Cys His Arg Gln Val Leu Gln Thr Arg Glu Lys Ile Thr Thr 
385                 390                 395                 400 


Asn Cys Tyr Lys Phe Lys Ile Lys Asp Gly Ser Phe Ile Thr Leu Arg 
                405                 410                 415     


Ser Arg Trp Phe Ser Phe Met Asn Pro Trp Thr Lys Glu Val Glu Tyr 
            420                 425                 430         


Ile Val Ser Thr Asn Thr Val Val Leu Ala Asn Val Leu Glu Gly Gly 
        435                 440                 445             


Asp Pro Thr Phe Pro Gln Leu Thr Ala Ser Pro His Ser Met Asp Ser 
    450                 455                 460                 


Met Leu Pro Ser Gly Glu Gly Gly Pro Lys Arg Thr His Pro Thr Val 
465                 470                 475                 480 


Pro Gly Ile Pro Gly Gly Thr Arg Ala Gly Ala Gly Lys Ile Gly Arg 
                485                 490                 495     


Met Ile Ala Glu Glu Ile Met Glu Ile His Arg Ile Arg Gly Ser Ser 
            500                 505                 510         


Pro Ser Ser Cys Gly Ser Ser Pro Leu Asn Ile Thr Ser Thr Pro Pro 
        515                 520                 525             


Pro Asp Ala Ser Ser Pro Gly Gly Lys Lys Ile Leu Asn Gly Gly Thr 
    530                 535                 540                 


Pro Asp Ile Pro Ser Ser Gly Leu Leu Ser Gly Gln Ala Gln Glu Asn 
545                 550                 555                 560 


Pro Gly Tyr Pro Tyr Ser Asp Ser Ser Ser Ile Leu Gly Glu Asn Pro 
                565                 570                 575     


His Ile Gly Ile Asp Met Ile Asp Asn Asp Gln Gly Ser Ser Ser Pro 
            580                 585                 590         


Ser Asn Asp Glu Ala Ala Met Ala Val Ile Met Ser Leu Leu Glu Ala 
        595                 600                 605             


Asp Ala Gly Leu Gly Gly Pro Val Asp Phe Ser Asp Leu Pro Trp Pro 
    610                 615                 620                 


Leu 
625 


<210>  1083
<211>  60
<212>  PRT
<213>  Homo Sapiens

<400>  1083

Met Ala Asp Gln Arg Met Asp Ile Ser Ser Thr Ile Ser Asp Phe Met 
1               5                   10                  15      


Ser Pro Gly Pro Thr Asp Leu Leu Ser Ser Ser Leu Gly Thr Ser Gly 
            20                  25                  30          


Val Asp Cys Asn Arg Lys Arg Lys Gly Ser Ser Thr Asp Tyr Gln Leu 
        35                  40                  45              


Glu Tyr Thr Glu His Gln Gly Arg Ile Lys Asn Ala 
    50                  55                  60  


<210>  1084
<211>  46
<212>  PRT
<213>  Homo Sapiens

<400>  1084

Met Ile Asn Ile Glu Ser Met Asp Thr Asp Lys Asp Asp Pro His Gly 
1               5                   10                  15      


Arg Leu Glu Tyr Thr Glu His Gln Gly Arg Ile Lys Asn Ala Arg Glu 
            20                  25                  30          


Ala His Ser Gln Ile Glu Lys Arg Arg Arg Asp Lys Met Asn 
        35                  40                  45      


<210>  1085
<211>  72
<212>  PRT
<213>  Homo Sapiens

<400>  1085

Met Ile Asn Ile Glu Ser Met Asp Thr Asp Lys Asp Asp Pro His Gly 
1               5                   10                  15      


Arg Leu Glu Tyr Thr Glu His Gln Gly Arg Ile Lys Asn Ala Arg Glu 
            20                  25                  30          


Ala His Ser Gln Ile Glu Lys Arg Arg Arg Asp Lys Met Asn Ser Phe 
        35                  40                  45              


Ile Asp Glu Leu Ala Ser Leu Val Pro Thr Cys Asn Ala Met Ser Arg 
    50                  55                  60                  


Lys Leu Asp Lys Leu Thr Val Leu 
65                  70          


<210>  1086
<211>  141
<212>  PRT
<213>  Homo Sapiens

<400>  1086

Met Ile Asn Ile Glu Ser Met Asp Thr Asp Lys Asp Asp Pro His Gly 
1               5                   10                  15      


Arg Leu Glu Tyr Thr Glu His Gln Gly Arg Ile Lys Asn Ala Arg Glu 
            20                  25                  30          


Ala His Ser Gln Ile Glu Lys Arg Arg Arg Asp Lys Met Asn Ser Phe 
        35                  40                  45              


Ile Asp Glu Leu Ala Ser Leu Val Pro Thr Cys Asn Ala Met Ser Arg 
    50                  55                  60                  


Lys Leu Asp Lys Leu Thr Val Leu Arg Met Ala Val Gln His Met Lys 
65                  70                  75                  80  


Thr Leu Arg Gly Ala Thr Asn Pro Tyr Thr Glu Ala Asn Tyr Lys Pro 
                85                  90                  95      


Thr Phe Leu Ser Asp Asp Glu Leu Lys His Leu Ile Leu Arg Ala Ala 
            100                 105                 110         


Asp Gly Phe Leu Phe Val Val Gly Cys Asp Arg Gly Lys Ile Leu Phe 
        115                 120                 125             


Val Ser Glu Ser Val Phe Lys Ile Leu Asn Tyr Ser Gln 
    130                 135                 140     


<210>  1087
<211>  583
<212>  PRT
<213>  Homo Sapiens

<400>  1087

Met Ile Asn Ile Glu Ser Met Asp Thr Asp Lys Asp Asp Pro His Gly 
1               5                   10                  15      


Arg Leu Glu Tyr Thr Glu His Gln Gly Arg Ile Lys Asn Ala Arg Glu 
            20                  25                  30          


Ala His Ser Gln Ile Glu Lys Arg Arg Arg Asp Lys Met Asn Ser Phe 
        35                  40                  45              


Ile Asp Glu Leu Ala Ser Leu Val Pro Thr Cys Asn Ala Met Ser Arg 
    50                  55                  60                  


Lys Leu Asp Lys Leu Thr Val Leu Arg Met Ala Val Gln His Met Lys 
65                  70                  75                  80  


Thr Leu Arg Gly Ala Thr Asn Pro Tyr Thr Glu Ala Asn Tyr Lys Pro 
                85                  90                  95      


Thr Phe Leu Ser Asp Asp Glu Leu Lys His Leu Ile Leu Arg Ala Ala 
            100                 105                 110         


Asp Gly Phe Leu Phe Val Val Gly Cys Asp Arg Gly Lys Ile Leu Phe 
        115                 120                 125             


Val Ser Glu Ser Val Phe Lys Ile Leu Asn Tyr Ser Gln Asn Asp Leu 
    130                 135                 140                 


Ile Gly Gln Ser Leu Phe Asp Tyr Leu His Pro Lys Asp Ile Ala Lys 
145                 150                 155                 160 


Val Lys Glu Gln Leu Ser Ser Ser Asp Thr Ala Pro Arg Glu Arg Leu 
                165                 170                 175     


Ile Asp Ala Lys Thr Gly Leu Pro Val Lys Thr Asp Ile Thr Pro Gly 
            180                 185                 190         


Pro Ser Arg Leu Cys Ser Gly Ala Arg Arg Ser Phe Phe Cys Arg Met 
        195                 200                 205             


Lys Cys Asn Arg Pro Ser Val Lys Val Glu Asp Lys Asp Phe Pro Ser 
    210                 215                 220                 


Thr Cys Ser Lys Lys Lys Ala Asp Arg Lys Ser Phe Cys Thr Ile His 
225                 230                 235                 240 


Ser Thr Gly Tyr Leu Lys Ser Trp Pro Pro Thr Lys Met Gly Leu Asp 
                245                 250                 255     


Glu Asp Asn Glu Pro Asp Asn Glu Gly Cys Asn Leu Ser Cys Leu Val 
            260                 265                 270         


Ala Ile Gly Arg Leu His Ser His Val Val Pro Gln Pro Val Asn Gly 
        275                 280                 285             


Glu Ile Arg Val Lys Ser Met Glu Tyr Val Ser Arg His Ala Ile Asp 
    290                 295                 300                 


Gly Lys Phe Val Phe Val Asp Gln Arg Ala Thr Ala Ile Leu Ala Tyr 
305                 310                 315                 320 


Leu Pro Gln Glu Leu Leu Gly Thr Ser Cys Tyr Glu Tyr Phe His Gln 
                325                 330                 335     


Asp Asp Ile Gly His Leu Ala Glu Cys His Arg Gln Val Leu Gln Thr 
            340                 345                 350         


Arg Glu Lys Ile Thr Thr Asn Cys Tyr Lys Phe Lys Ile Lys Asp Gly 
        355                 360                 365             


Ser Phe Ile Thr Leu Arg Ser Arg Trp Phe Ser Phe Met Asn Pro Trp 
    370                 375                 380                 


Thr Lys Glu Val Glu Tyr Ile Val Ser Thr Asn Thr Val Val Leu Ala 
385                 390                 395                 400 


Asn Val Leu Glu Gly Gly Asp Pro Thr Phe Pro Gln Leu Thr Ala Ser 
                405                 410                 415     


Pro His Ser Met Asp Ser Met Leu Pro Ser Gly Glu Gly Gly Pro Lys 
            420                 425                 430         


Arg Thr His Pro Thr Val Pro Gly Ile Pro Gly Gly Thr Arg Ala Gly 
        435                 440                 445             


Ala Gly Lys Ile Gly Arg Met Ile Ala Glu Glu Ile Met Glu Ile His 
    450                 455                 460                 


Arg Ile Arg Gly Ser Ser Pro Ser Ser Cys Gly Ser Ser Pro Leu Asn 
465                 470                 475                 480 


Ile Thr Ser Thr Pro Pro Pro Asp Ala Ser Ser Pro Gly Gly Lys Lys 
                485                 490                 495     


Ile Leu Asn Gly Gly Thr Pro Asp Ile Pro Ser Ser Gly Leu Leu Ser 
            500                 505                 510         


Gly Gln Ala Gln Glu Asn Pro Gly Tyr Pro Tyr Ser Asp Ser Ser Ser 
        515                 520                 525             


Ile Leu Gly Glu Asn Pro His Ile Gly Ile Asp Met Ile Asp Asn Asp 
    530                 535                 540                 


Gln Gly Ser Ser Ser Pro Ser Asn Asp Glu Ala Ala Met Ala Val Ile 
545                 550                 555                 560 


Met Ser Leu Leu Glu Ala Asp Ala Gly Leu Gly Gly Pro Val Asp Phe 
                565                 570                 575     


Ser Asp Leu Pro Trp Pro Leu 
            580             


<210>  1088
<211>  582
<212>  PRT
<213>  Homo Sapiens

<400>  1088

Met Ile Asn Ile Glu Ser Met Asp Thr Asp Lys Asp Asp Pro His Gly 
1               5                   10                  15      


Arg Leu Glu Tyr Thr Glu His Gln Gly Arg Ile Lys Asn Ala Arg Glu 
            20                  25                  30          


Ala His Ser Gln Ile Glu Lys Arg Arg Arg Asp Lys Met Asn Ser Phe 
        35                  40                  45              


Ile Asp Glu Leu Ala Ser Leu Val Pro Thr Cys Asn Ala Met Ser Arg 
    50                  55                  60                  


Lys Leu Asp Lys Leu Thr Val Leu Arg Met Ala Val Gln His Met Lys 
65                  70                  75                  80  


Thr Leu Arg Gly Ala Thr Asn Pro Tyr Thr Glu Ala Asn Tyr Lys Pro 
                85                  90                  95      


Thr Phe Leu Ser Asp Asp Glu Leu Lys His Leu Ile Leu Arg Ala Ala 
            100                 105                 110         


Asp Gly Phe Leu Phe Val Val Gly Cys Asp Arg Gly Lys Ile Leu Phe 
        115                 120                 125             


Val Ser Glu Ser Val Phe Lys Ile Leu Asn Tyr Ser Gln Asn Asp Leu 
    130                 135                 140                 


Ile Gly Gln Ser Leu Phe Asp Tyr Leu His Pro Lys Asp Ile Ala Lys 
145                 150                 155                 160 


Val Lys Glu Gln Leu Ser Ser Ser Asp Thr Ala Pro Arg Glu Arg Leu 
                165                 170                 175     


Ile Asp Ala Lys Thr Gly Leu Pro Val Lys Thr Asp Ile Thr Pro Gly 
            180                 185                 190         


Pro Ser Arg Leu Cys Ser Gly Ala Arg Arg Ser Phe Phe Cys Arg Met 
        195                 200                 205             


Lys Cys Asn Arg Pro Ser Val Lys Val Glu Asp Lys Asp Phe Pro Ser 
    210                 215                 220                 


Thr Cys Ser Lys Lys Lys Asp Arg Lys Ser Phe Cys Thr Ile His Ser 
225                 230                 235                 240 


Thr Gly Tyr Leu Lys Ser Trp Pro Pro Thr Lys Met Gly Leu Asp Glu 
                245                 250                 255     


Asp Asn Glu Pro Asp Asn Glu Gly Cys Asn Leu Ser Cys Leu Val Ala 
            260                 265                 270         


Ile Gly Arg Leu His Ser His Val Val Pro Gln Pro Val Asn Gly Glu 
        275                 280                 285             


Ile Arg Val Lys Ser Met Glu Tyr Val Ser Arg His Ala Ile Asp Gly 
    290                 295                 300                 


Lys Phe Val Phe Val Asp Gln Arg Ala Thr Ala Ile Leu Ala Tyr Leu 
305                 310                 315                 320 


Pro Gln Glu Leu Leu Gly Thr Ser Cys Tyr Glu Tyr Phe His Gln Asp 
                325                 330                 335     


Asp Ile Gly His Leu Ala Glu Cys His Arg Gln Val Leu Gln Thr Arg 
            340                 345                 350         


Glu Lys Ile Thr Thr Asn Cys Tyr Lys Phe Lys Ile Lys Asp Gly Ser 
        355                 360                 365             


Phe Ile Thr Leu Arg Ser Arg Trp Phe Ser Phe Met Asn Pro Trp Thr 
    370                 375                 380                 


Lys Glu Val Glu Tyr Ile Val Ser Thr Asn Thr Val Val Leu Ala Asn 
385                 390                 395                 400 


Val Leu Glu Gly Gly Asp Pro Thr Phe Pro Gln Leu Thr Ala Ser Pro 
                405                 410                 415     


His Ser Met Asp Ser Met Leu Pro Ser Gly Glu Gly Gly Pro Lys Arg 
            420                 425                 430         


Thr His Pro Thr Val Pro Gly Ile Pro Gly Gly Thr Arg Ala Gly Ala 
        435                 440                 445             


Gly Lys Ile Gly Arg Met Ile Ala Glu Glu Ile Met Glu Ile His Arg 
    450                 455                 460                 


Ile Arg Gly Ser Ser Pro Ser Ser Cys Gly Ser Ser Pro Leu Asn Ile 
465                 470                 475                 480 


Thr Ser Thr Pro Pro Pro Asp Ala Ser Ser Pro Gly Gly Lys Lys Ile 
                485                 490                 495     


Leu Asn Gly Gly Thr Pro Asp Ile Pro Ser Ser Gly Leu Leu Ser Gly 
            500                 505                 510         


Gln Ala Gln Glu Asn Pro Gly Tyr Pro Tyr Ser Asp Ser Ser Ser Ile 
        515                 520                 525             


Leu Gly Glu Asn Pro His Ile Gly Ile Asp Met Ile Asp Asn Asp Gln 
    530                 535                 540                 


Gly Ser Ser Ser Pro Ser Asn Asp Glu Ala Ala Met Ala Val Ile Met 
545                 550                 555                 560 


Ser Leu Leu Glu Ala Asp Ala Gly Leu Gly Gly Pro Val Asp Phe Ser 
                565                 570                 575     


Asp Leu Pro Trp Pro Leu 
            580         


<210>  1089
<211>  624
<212>  PRT
<213>  Homo Sapiens

<400>  1089

Met Ser Lys Glu Ala Val Ser Leu Trp Ala Leu Thr Val Ser Leu Gln 
1               5                   10                  15      


Pro Pro Val Pro Leu Cys Val Cys Arg Glu Met Thr Gly Ser Gly Arg 
            20                  25                  30          


Arg Lys Gln Gln Cys Val Thr Leu Pro Phe Ile Ser Arg Glu Leu Cys 
        35                  40                  45              


Phe Tyr Leu Leu Leu Phe Pro Pro Pro Arg Leu Glu Tyr Thr Glu His 
    50                  55                  60                  


Gln Gly Arg Ile Lys Asn Ala Arg Glu Ala His Ser Gln Ile Glu Lys 
65                  70                  75                  80  


Arg Arg Arg Asp Lys Met Asn Ser Phe Ile Asp Glu Leu Ala Ser Leu 
                85                  90                  95      


Val Pro Thr Cys Asn Ala Met Ser Arg Lys Leu Asp Lys Leu Thr Val 
            100                 105                 110         


Leu Arg Met Ala Val Gln His Met Lys Thr Leu Arg Gly Ala Thr Asn 
        115                 120                 125             


Pro Tyr Thr Glu Ala Asn Tyr Lys Pro Thr Phe Leu Ser Asp Asp Glu 
    130                 135                 140                 


Leu Lys His Leu Ile Leu Arg Ala Ala Asp Gly Phe Leu Phe Val Val 
145                 150                 155                 160 


Gly Cys Asp Arg Gly Lys Ile Leu Phe Val Ser Glu Ser Val Phe Lys 
                165                 170                 175     


Ile Leu Asn Tyr Ser Gln Asn Asp Leu Ile Gly Gln Ser Leu Phe Asp 
            180                 185                 190         


Tyr Leu His Pro Lys Asp Ile Ala Lys Val Lys Glu Gln Leu Ser Ser 
        195                 200                 205             


Ser Asp Thr Ala Pro Arg Glu Arg Leu Ile Asp Ala Lys Thr Gly Leu 
    210                 215                 220                 


Pro Val Lys Thr Asp Ile Thr Pro Gly Pro Ser Arg Leu Cys Ser Gly 
225                 230                 235                 240 


Ala Arg Arg Ser Phe Phe Cys Arg Met Lys Cys Asn Arg Pro Ser Val 
                245                 250                 255     


Lys Val Glu Asp Lys Asp Phe Pro Ser Thr Cys Ser Lys Lys Lys Ala 
            260                 265                 270         


Asp Arg Lys Ser Phe Cys Thr Ile His Ser Thr Gly Tyr Leu Lys Ser 
        275                 280                 285             


Trp Pro Pro Thr Lys Met Gly Leu Asp Glu Asp Asn Glu Pro Asp Asn 
    290                 295                 300                 


Glu Gly Cys Asn Leu Ser Cys Leu Val Ala Ile Gly Arg Leu His Ser 
305                 310                 315                 320 


His Val Val Pro Gln Pro Val Asn Gly Glu Ile Arg Val Lys Ser Met 
                325                 330                 335     


Glu Tyr Val Ser Arg His Ala Ile Asp Gly Lys Phe Val Phe Val Asp 
            340                 345                 350         


Gln Arg Ala Thr Ala Ile Leu Ala Tyr Leu Pro Gln Glu Leu Leu Gly 
        355                 360                 365             


Thr Ser Cys Tyr Glu Tyr Phe His Gln Asp Asp Ile Gly His Leu Ala 
    370                 375                 380                 


Glu Cys His Arg Gln Val Leu Gln Thr Arg Glu Lys Ile Thr Thr Asn 
385                 390                 395                 400 


Cys Tyr Lys Phe Lys Ile Lys Asp Gly Ser Phe Ile Thr Leu Arg Ser 
                405                 410                 415     


Arg Trp Phe Ser Phe Met Asn Pro Trp Thr Lys Glu Val Glu Tyr Ile 
            420                 425                 430         


Val Ser Thr Asn Thr Val Val Leu Ala Asn Val Leu Glu Gly Gly Asp 
        435                 440                 445             


Pro Thr Phe Pro Gln Leu Thr Ala Ser Pro His Ser Met Asp Ser Met 
    450                 455                 460                 


Leu Pro Ser Gly Glu Gly Gly Pro Lys Arg Thr His Pro Thr Val Pro 
465                 470                 475                 480 


Gly Ile Pro Gly Gly Thr Arg Ala Gly Ala Gly Lys Ile Gly Arg Met 
                485                 490                 495     


Ile Ala Glu Glu Ile Met Glu Ile His Arg Ile Arg Gly Ser Ser Pro 
            500                 505                 510         


Ser Ser Cys Gly Ser Ser Pro Leu Asn Ile Thr Ser Thr Pro Pro Pro 
        515                 520                 525             


Asp Ala Ser Ser Pro Gly Gly Lys Lys Ile Leu Asn Gly Gly Thr Pro 
    530                 535                 540                 


Asp Ile Pro Ser Ser Gly Leu Leu Ser Gly Gln Ala Gln Glu Asn Pro 
545                 550                 555                 560 


Gly Tyr Pro Tyr Ser Asp Ser Ser Ser Ile Leu Gly Glu Asn Pro His 
                565                 570                 575     


Ile Gly Ile Asp Met Ile Asp Asn Asp Gln Gly Ser Ser Ser Pro Ser 
            580                 585                 590         


Asn Asp Glu Ala Ala Met Ala Val Ile Met Ser Leu Leu Glu Ala Asp 
        595                 600                 605             


Ala Gly Leu Gly Gly Pro Val Asp Phe Ser Asp Leu Pro Trp Pro Leu 
    610                 615                 620                 


<210>  1090
<211>  171
<212>  PRT
<213>  Homo Sapiens

<400>  1090

Arg Ala Thr Ala Ile Leu Ala Tyr Leu Pro Gln Glu Leu Leu Gly Thr 
1               5                   10                  15      


Ser Cys Tyr Glu Tyr Phe His Gln Asp Asp Ile Gly His Leu Ala Glu 
            20                  25                  30          


Cys His Arg Gln Val Leu Gln Thr Arg Glu Lys Ile Thr Thr Asn Cys 
        35                  40                  45              


Tyr Lys Phe Lys Ile Lys Asp Gly Ser Phe Ile Thr Leu Arg Ser Arg 
    50                  55                  60                  


Trp Phe Ser Phe Met Asn Pro Trp Thr Lys Glu Val Glu Tyr Ile Val 
65                  70                  75                  80  


Ser Thr Asn Thr Val Val Leu Ser Arg Val Asp Thr Gly His Leu Gly 
                85                  90                  95      


Gln Val Glu Trp Cys Thr Val Leu Ser Arg Pro Asp Ser Arg Phe Leu 
            100                 105                 110         


Ile Ala Gly Met Phe Thr Glu Pro Thr Ser Trp Lys Ala Gly Thr Gln 
        115                 120                 125             


Pro Ser His Ser Ser Gln His Pro Pro Thr Ala Trp Thr Ala Cys Cys 
    130                 135                 140                 


Pro Leu Glu Lys Val Ala Gln Arg Gly Pro Thr Pro Leu Phe Gln Gly 
145                 150                 155                 160 


Phe Gln Gly Glu Pro Gly Leu Gly Gln Glu Lys 
                165                 170     


<210>  1091
<211>  423
<212>  PRT
<213>  Homo Sapiens

<400>  1091

Met Gly Met Tyr Pro Gly Val Leu Val Pro Ser Ser Arg Gly Gly Leu 
1               5                   10                  15      


Pro Leu Glu Glu Val Thr Val Ala Glu Val Leu Ala Ala Arg Gly Tyr 
            20                  25                  30          


Leu Thr Gly Met Ala Gly Lys Trp His Leu Gly Val Gly Pro Glu Gly 
        35                  40                  45              


Ala Phe Leu Pro Pro His Gln Gly Phe His Arg Phe Leu Gly Ile Pro 
    50                  55                  60                  


Tyr Ser His Asp Gln Gly Pro Cys Gln Asn Leu Thr Cys Phe Pro Pro 
65                  70                  75                  80  


Ala Thr Pro Cys Asp Gly Gly Cys Asp Gln Gly Leu Val Pro Ile Pro 
                85                  90                  95      


Leu Leu Ala Asn Leu Ser Val Glu Ala Gln Pro Pro Trp Leu Pro Gly 
            100                 105                 110         


Leu Glu Ala Arg Tyr Met Ala Phe Ala His Asp Leu Met Ala Asp Ala 
        115                 120                 125             


Gln Arg Gln Asp Arg Pro Phe Phe Leu Tyr Tyr Ala Ser His His Thr 
    130                 135                 140                 


His Tyr Pro Gln Phe Ser Gly Gln Ser Phe Ala Glu Arg Ser Gly Arg 
145                 150                 155                 160 


Gly Pro Phe Gly Asp Ser Leu Met Glu Leu Asp Ala Ala Val Gly Thr 
                165                 170                 175     


Leu Met Thr Ala Ile Gly Asp Leu Gly Leu Leu Glu Glu Thr Leu Val 
            180                 185                 190         


Ile Phe Thr Ala Asp Asn Gly Pro Glu Thr Met Arg Met Ser Arg Gly 
        195                 200                 205             


Gly Cys Ser Gly Leu Leu Arg Cys Gly Lys Gly Thr Thr Tyr Glu Gly 
    210                 215                 220                 


Gly Val Arg Glu Pro Ala Leu Ala Phe Trp Pro Gly His Ile Ala Pro 
225                 230                 235                 240 


Gly Val Thr His Glu Leu Ala Ser Ser Leu Asp Leu Leu Pro Thr Leu 
                245                 250                 255     


Ala Ala Leu Ala Gly Ala Pro Leu Pro Asn Val Thr Leu Asp Gly Phe 
            260                 265                 270         


Asp Leu Ser Pro Leu Leu Leu Gly Thr Gly Lys Ser Pro Arg Gln Ser 
        275                 280                 285             


Leu Phe Phe Tyr Pro Ser Tyr Pro Asp Glu Val Arg Gly Val Phe Ala 
    290                 295                 300                 


Val Arg Thr Gly Lys Tyr Lys Ala His Phe Phe Thr Gln Gly Ser Ala 
305                 310                 315                 320 


His Ser Asp Thr Thr Ala Asp Pro Ala Cys His Ala Ser Ser Ser Leu 
                325                 330                 335     


Thr Ala His Glu Pro Pro Leu Leu Tyr Asp Leu Ser Lys Asp Pro Gly 
            340                 345                 350         


Glu Asn Tyr Asn Leu Leu Gly Gly Val Ala Gly Ala Thr Pro Glu Val 
        355                 360                 365             


Leu Gln Ala Leu Lys Gln Leu Gln Leu Leu Lys Ala Gln Leu Asp Ala 
    370                 375                 380                 


Ala Val Thr Phe Gly Pro Ser Gln Val Ala Arg Gly Glu Asp Pro Ala 
385                 390                 395                 400 


Leu Gln Ile Cys Cys His Pro Gly Cys Thr Pro Arg Pro Ala Cys Cys 
                405                 410                 415     


His Cys Pro Asp Pro His Ala 
            420             


<210>  1092
<211>  509
<212>  PRT
<213>  Homo Sapiens

<400>  1092

Met Ser Met Gly Ala Pro Arg Ser Leu Leu Leu Ala Leu Ala Ala Gly 
1               5                   10                  15      


Leu Ala Val Ala Arg Pro Pro Asn Ile Val Leu Ile Phe Ala Asp Asp 
            20                  25                  30          


Leu Gly Tyr Gly Asp Leu Gly Cys Tyr Gly His Pro Ser Ser Thr Thr 
        35                  40                  45              


Pro Asn Leu Asp Gln Leu Ala Ala Gly Gly Leu Arg Phe Thr Asp Phe 
    50                  55                  60                  


Tyr Val Pro Val Ser Leu Cys Thr Pro Ser Arg Ala Ala Leu Leu Thr 
65                  70                  75                  80  


Gly Arg Leu Pro Val Arg Met Gly Met Tyr Pro Gly Val Leu Val Pro 
                85                  90                  95      


Ser Ser Arg Gly Gly Leu Pro Leu Glu Glu Val Thr Val Ala Glu Val 
            100                 105                 110         


Leu Ala Ala Arg Gly Tyr Leu Thr Gly Met Ala Gly Lys Trp His Leu 
        115                 120                 125             


Gly Val Gly Pro Glu Gly Ala Phe Leu Pro Pro His Gln Gly Phe His 
    130                 135                 140                 


Arg Phe Leu Gly Ile Pro Tyr Ser His Asp Gln Gly Pro Cys Gln Asn 
145                 150                 155                 160 


Leu Thr Cys Phe Pro Pro Ala Thr Pro Cys Asp Gly Gly Cys Asp Gln 
                165                 170                 175     


Gly Leu Val Pro Ile Pro Leu Leu Ala Asn Leu Ser Val Glu Ala Gln 
            180                 185                 190         


Pro Pro Trp Leu Pro Gly Leu Glu Ala Arg Tyr Met Ala Phe Ala His 
        195                 200                 205             


Asp Leu Met Ala Asp Ala Gln Arg Gln Asp Arg Pro Phe Phe Leu Tyr 
    210                 215                 220                 


Tyr Ala Ser His His Thr His Tyr Pro Gln Phe Ser Gly Gln Ser Phe 
225                 230                 235                 240 


Ala Glu Arg Ser Gly Arg Gly Pro Phe Gly Asp Ser Leu Met Glu Leu 
                245                 250                 255     


Asp Ala Ala Val Gly Thr Leu Met Thr Ala Ile Gly Asp Leu Gly Leu 
            260                 265                 270         


Leu Glu Glu Thr Leu Val Ile Phe Thr Ala Asp Asn Gly Pro Glu Thr 
        275                 280                 285             


Met Arg Met Ser Arg Gly Gly Cys Ser Gly Leu Leu Arg Cys Gly Lys 
    290                 295                 300                 


Gly Thr Thr Tyr Glu Gly Gly Val Arg Glu Pro Ala Leu Ala Phe Trp 
305                 310                 315                 320 


Pro Gly His Ile Ala Pro Gly Val Thr His Glu Leu Ala Ser Ser Leu 
                325                 330                 335     


Asp Leu Leu Pro Thr Leu Ala Ala Leu Ala Gly Ala Pro Leu Pro Asn 
            340                 345                 350         


Val Thr Leu Asp Gly Phe Asp Leu Ser Pro Leu Leu Leu Gly Thr Gly 
        355                 360                 365             


Lys Ser Pro Arg Gln Ser Leu Phe Phe Tyr Pro Ser Tyr Pro Asp Glu 
    370                 375                 380                 


Val Arg Gly Val Phe Ala Val Arg Thr Gly Lys Tyr Lys Ala His Phe 
385                 390                 395                 400 


Phe Thr Gln Gly Ser Ala His Ser Asp Thr Thr Ala Asp Pro Ala Cys 
                405                 410                 415     


His Ala Ser Ser Ser Leu Thr Ala His Glu Pro Pro Leu Leu Tyr Asp 
            420                 425                 430         


Leu Ser Lys Asp Pro Gly Glu Asn Tyr Asn Leu Leu Gly Gly Val Ala 
        435                 440                 445             


Gly Ala Thr Pro Glu Val Leu Gln Ala Leu Lys Gln Leu Gln Leu Leu 
    450                 455                 460                 


Lys Ala Gln Leu Asp Ala Ala Val Thr Phe Gly Pro Ser Gln Val Ala 
465                 470                 475                 480 


Arg Gly Glu Asp Pro Ala Leu Gln Ile Cys Cys His Pro Gly Cys Thr 
                485                 490                 495     


Pro Arg Pro Ala Cys Cys His Cys Pro Asp Pro His Ala 
            500                 505                 


<210>  1093
<211>  509
<212>  PRT
<213>  Homo Sapiens

<400>  1093

Met Ser Met Gly Ala Pro Arg Ser Leu Leu Leu Ala Leu Ala Ala Gly 
1               5                   10                  15      


Leu Ala Val Ala Arg Pro Pro Asn Ile Val Leu Ile Phe Ala Asp Asp 
            20                  25                  30          


Leu Gly Tyr Gly Asp Leu Gly Cys Tyr Gly His Pro Ser Ser Thr Thr 
        35                  40                  45              


Pro Asn Leu Asp Gln Leu Ala Ala Gly Gly Leu Arg Phe Thr Asp Phe 
    50                  55                  60                  


Tyr Val Pro Val Ser Leu Cys Thr Pro Ser Arg Ala Ala Leu Leu Thr 
65                  70                  75                  80  


Gly Arg Leu Pro Val Arg Met Gly Met Tyr Pro Gly Val Leu Val Pro 
                85                  90                  95      


Ser Ser Arg Gly Gly Leu Pro Leu Glu Glu Val Thr Val Ala Glu Val 
            100                 105                 110         


Leu Ala Ala Arg Gly Tyr Leu Thr Gly Met Ala Gly Lys Trp His Leu 
        115                 120                 125             


Gly Val Gly Pro Glu Gly Ala Phe Leu Pro Pro His Gln Gly Phe His 
    130                 135                 140                 


Arg Phe Leu Gly Ile Pro Tyr Ser His Asp Gln Gly Pro Cys Gln Asn 
145                 150                 155                 160 


Leu Thr Cys Phe Pro Pro Ala Thr Pro Cys Asp Gly Gly Cys Asp Gln 
                165                 170                 175     


Gly Leu Val Pro Ile Pro Leu Leu Ala Asn Leu Ser Val Glu Ala Gln 
            180                 185                 190         


Pro Pro Trp Leu Pro Gly Leu Glu Ala Arg Tyr Met Ala Phe Ala His 
        195                 200                 205             


Asp Leu Met Ala Asp Ala Gln Arg Gln Asp Arg Pro Phe Phe Leu Tyr 
    210                 215                 220                 


Tyr Ala Ser His His Thr His Tyr Pro Gln Phe Ser Gly Gln Ser Phe 
225                 230                 235                 240 


Ala Glu Arg Ser Gly Arg Gly Pro Phe Gly Asp Ser Leu Met Glu Leu 
                245                 250                 255     


Asp Ala Ala Val Gly Thr Leu Met Thr Ala Ile Gly Asp Leu Gly Leu 
            260                 265                 270         


Leu Glu Glu Thr Leu Val Ile Phe Thr Ala Asp Asn Gly Pro Glu Thr 
        275                 280                 285             


Met Arg Met Ser Arg Gly Gly Cys Ser Gly Leu Leu Arg Cys Gly Lys 
    290                 295                 300                 


Gly Thr Thr Tyr Glu Gly Gly Val Arg Glu Pro Ala Leu Ala Phe Trp 
305                 310                 315                 320 


Pro Gly His Ile Ala Pro Gly Val Thr His Glu Leu Ala Ser Ser Leu 
                325                 330                 335     


Asp Leu Leu Pro Thr Leu Ala Ala Leu Ala Gly Ala Pro Leu Pro Asn 
            340                 345                 350         


Val Thr Leu Asp Gly Phe Asp Leu Ser Pro Leu Leu Leu Gly Thr Gly 
        355                 360                 365             


Lys Ser Pro Arg Gln Ser Leu Phe Phe Tyr Pro Ser Tyr Pro Asp Glu 
    370                 375                 380                 


Val Arg Gly Val Phe Ala Val Arg Thr Gly Lys Tyr Lys Ala His Phe 
385                 390                 395                 400 


Phe Thr Gln Gly Ser Ala His Ser Asp Thr Thr Ala Asp Pro Ala Cys 
                405                 410                 415     


His Ala Ser Ser Ser Leu Thr Ala His Glu Pro Pro Leu Leu Tyr Asp 
            420                 425                 430         


Leu Ser Lys Asp Pro Gly Glu Asn Tyr Asn Leu Leu Gly Gly Val Ala 
        435                 440                 445             


Gly Ala Thr Pro Glu Val Leu Gln Ala Leu Lys Gln Leu Gln Leu Leu 
    450                 455                 460                 


Lys Ala Gln Leu Asp Ala Ala Val Thr Phe Gly Pro Ser Gln Val Ala 
465                 470                 475                 480 


Arg Gly Glu Asp Pro Ala Leu Gln Ile Cys Cys His Pro Gly Cys Thr 
                485                 490                 495     


Pro Arg Pro Ala Cys Cys His Cys Pro Asp Pro His Ala 
            500                 505                 


<210>  1094
<211>  509
<212>  PRT
<213>  Homo Sapiens

<400>  1094

Met Ser Met Gly Ala Pro Arg Ser Leu Leu Leu Ala Leu Ala Ala Gly 
1               5                   10                  15      


Leu Ala Val Ala Arg Pro Pro Asn Ile Val Leu Ile Phe Ala Asp Asp 
            20                  25                  30          


Leu Gly Tyr Gly Asp Leu Gly Cys Tyr Gly His Pro Ser Ser Thr Thr 
        35                  40                  45              


Pro Asn Leu Asp Gln Leu Ala Ala Gly Gly Leu Arg Phe Thr Asp Phe 
    50                  55                  60                  


Tyr Val Pro Val Ser Leu Cys Thr Pro Ser Arg Ala Ala Leu Leu Thr 
65                  70                  75                  80  


Gly Arg Leu Pro Val Arg Met Gly Met Tyr Pro Gly Val Leu Val Pro 
                85                  90                  95      


Ser Ser Arg Gly Gly Leu Pro Leu Glu Glu Val Thr Val Ala Glu Val 
            100                 105                 110         


Leu Ala Ala Arg Gly Tyr Leu Thr Gly Met Ala Gly Lys Trp His Leu 
        115                 120                 125             


Gly Val Gly Pro Glu Gly Ala Phe Leu Pro Pro His Gln Gly Phe His 
    130                 135                 140                 


Arg Phe Leu Gly Ile Pro Tyr Ser His Asp Gln Gly Pro Cys Gln Asn 
145                 150                 155                 160 


Leu Thr Cys Phe Pro Pro Ala Thr Pro Cys Asp Gly Gly Cys Asp Gln 
                165                 170                 175     


Gly Leu Val Pro Ile Pro Leu Leu Ala Asn Leu Ser Val Glu Ala Gln 
            180                 185                 190         


Pro Pro Trp Leu Pro Gly Leu Glu Ala Arg Tyr Met Ala Phe Ala His 
        195                 200                 205             


Asp Leu Met Ala Asp Ala Gln Arg Gln Asp Arg Pro Phe Phe Leu Tyr 
    210                 215                 220                 


Tyr Ala Ser His His Thr His Tyr Pro Gln Phe Ser Gly Gln Ser Phe 
225                 230                 235                 240 


Ala Glu Arg Ser Gly Arg Gly Pro Phe Gly Asp Ser Leu Met Glu Leu 
                245                 250                 255     


Asp Ala Ala Val Gly Thr Leu Met Thr Ala Ile Gly Asp Leu Gly Leu 
            260                 265                 270         


Leu Glu Glu Thr Leu Val Ile Phe Thr Ala Asp Asn Gly Pro Glu Thr 
        275                 280                 285             


Met Arg Met Ser Arg Gly Gly Cys Ser Gly Leu Leu Arg Cys Gly Lys 
    290                 295                 300                 


Gly Thr Thr Tyr Glu Gly Gly Val Arg Glu Pro Ala Leu Ala Phe Trp 
305                 310                 315                 320 


Pro Gly His Ile Ala Pro Gly Val Thr His Glu Leu Ala Ser Ser Leu 
                325                 330                 335     


Asp Leu Leu Pro Thr Leu Ala Ala Leu Ala Gly Ala Pro Leu Pro Asn 
            340                 345                 350         


Val Thr Leu Asp Gly Phe Asp Leu Ser Pro Leu Leu Leu Gly Thr Gly 
        355                 360                 365             


Lys Ser Pro Arg Gln Ser Leu Phe Phe Tyr Pro Ser Tyr Pro Asp Glu 
    370                 375                 380                 


Val Arg Gly Val Phe Ala Val Arg Thr Gly Lys Tyr Lys Ala His Phe 
385                 390                 395                 400 


Phe Thr Gln Gly Ser Ala His Ser Asp Thr Thr Ala Asp Pro Ala Cys 
                405                 410                 415     


His Ala Ser Ser Ser Leu Thr Ala His Glu Pro Pro Leu Leu Tyr Asp 
            420                 425                 430         


Leu Ser Lys Asp Pro Gly Glu Asn Tyr Asn Leu Leu Gly Gly Val Ala 
        435                 440                 445             


Gly Ala Thr Pro Glu Val Leu Gln Ala Leu Lys Gln Leu Gln Leu Leu 
    450                 455                 460                 


Lys Ala Gln Leu Asp Ala Ala Val Thr Phe Gly Pro Ser Gln Val Ala 
465                 470                 475                 480 


Arg Gly Glu Asp Pro Ala Leu Gln Ile Cys Cys His Pro Gly Cys Thr 
                485                 490                 495     


Pro Arg Pro Ala Cys Cys His Cys Pro Asp Pro His Ala 
            500                 505                 


<210>  1095
<211>  509
<212>  PRT
<213>  Homo Sapiens

<400>  1095

Met Ser Met Gly Ala Pro Arg Ser Leu Leu Leu Ala Leu Ala Ala Gly 
1               5                   10                  15      


Leu Ala Val Ala Arg Pro Pro Asn Ile Val Leu Ile Phe Ala Asp Asp 
            20                  25                  30          


Leu Gly Tyr Gly Asp Leu Gly Cys Tyr Gly His Pro Ser Ser Thr Thr 
        35                  40                  45              


Pro Asn Leu Asp Gln Leu Ala Ala Gly Gly Leu Arg Phe Thr Asp Phe 
    50                  55                  60                  


Tyr Val Pro Val Ser Leu Cys Thr Pro Ser Arg Ala Ala Leu Leu Thr 
65                  70                  75                  80  


Gly Arg Leu Pro Val Arg Met Gly Met Tyr Pro Gly Val Leu Val Pro 
                85                  90                  95      


Ser Ser Arg Gly Gly Leu Pro Leu Glu Glu Val Thr Val Ala Glu Val 
            100                 105                 110         


Leu Ala Ala Arg Gly Tyr Leu Thr Gly Met Ala Gly Lys Trp His Leu 
        115                 120                 125             


Gly Val Gly Pro Glu Gly Ala Phe Leu Pro Pro His Gln Gly Phe His 
    130                 135                 140                 


Arg Phe Leu Gly Ile Pro Tyr Ser His Asp Gln Gly Pro Cys Gln Asn 
145                 150                 155                 160 


Leu Thr Cys Phe Pro Pro Ala Thr Pro Cys Asp Gly Gly Cys Asp Gln 
                165                 170                 175     


Gly Leu Val Pro Ile Pro Leu Leu Ala Asn Leu Ser Val Glu Ala Gln 
            180                 185                 190         


Pro Pro Trp Leu Pro Gly Leu Glu Ala Arg Tyr Met Ala Phe Ala His 
        195                 200                 205             


Asp Leu Met Ala Asp Ala Gln Arg Gln Asp Arg Pro Phe Phe Leu Tyr 
    210                 215                 220                 


Tyr Ala Ser His His Thr His Tyr Pro Gln Phe Ser Gly Gln Ser Phe 
225                 230                 235                 240 


Ala Glu Arg Ser Gly Arg Gly Pro Phe Gly Asp Ser Leu Met Glu Leu 
                245                 250                 255     


Asp Ala Ala Val Gly Thr Leu Met Thr Ala Ile Gly Asp Leu Gly Leu 
            260                 265                 270         


Leu Glu Glu Thr Leu Val Ile Phe Thr Ala Asp Asn Gly Pro Glu Thr 
        275                 280                 285             


Met Arg Met Ser Arg Gly Gly Cys Ser Gly Leu Leu Arg Cys Gly Lys 
    290                 295                 300                 


Gly Thr Thr Tyr Glu Gly Gly Val Arg Glu Pro Ala Leu Ala Phe Trp 
305                 310                 315                 320 


Pro Gly His Ile Ala Pro Gly Val Thr His Glu Leu Ala Ser Ser Leu 
                325                 330                 335     


Asp Leu Leu Pro Thr Leu Ala Ala Leu Ala Gly Ala Pro Leu Pro Asn 
            340                 345                 350         


Val Thr Leu Asp Gly Phe Asp Leu Ser Pro Leu Leu Leu Gly Thr Gly 
        355                 360                 365             


Lys Ser Pro Arg Gln Ser Leu Phe Phe Tyr Pro Ser Tyr Pro Asp Glu 
    370                 375                 380                 


Val Arg Gly Val Phe Ala Val Arg Thr Gly Lys Tyr Lys Ala His Phe 
385                 390                 395                 400 


Phe Thr Gln Gly Ser Ala His Ser Asp Thr Thr Ala Asp Pro Ala Cys 
                405                 410                 415     


His Ala Ser Ser Ser Leu Thr Ala His Glu Pro Pro Leu Leu Tyr Asp 
            420                 425                 430         


Leu Ser Lys Asp Pro Gly Glu Asn Tyr Asn Leu Leu Gly Gly Val Ala 
        435                 440                 445             


Gly Ala Thr Pro Glu Val Leu Gln Ala Leu Lys Gln Leu Gln Leu Leu 
    450                 455                 460                 


Lys Ala Gln Leu Asp Ala Ala Val Thr Phe Gly Pro Ser Gln Val Ala 
465                 470                 475                 480 


Arg Gly Glu Asp Pro Ala Leu Gln Ile Cys Cys His Pro Gly Cys Thr 
                485                 490                 495     


Pro Arg Pro Ala Cys Cys His Cys Pro Asp Pro His Ala 
            500                 505                 


<210>  1096
<211>  69
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1096

Xaa Pro Ser Tyr Pro Asp Glu Val Arg Gly Val Phe Ala Val Arg Thr 
1               5                   10                  15      


Gly Lys Tyr Lys Ala His Phe Phe Thr Gln Gly Ser Ala His Ser Asp 
            20                  25                  30          


Thr Thr Ala Asp Pro Ala Cys His Ala Ser Ser Ser Leu Thr Ala His 
        35                  40                  45              


Glu Pro Pro Leu Leu Tyr Asp Leu Ser Lys Asp Pro Asp Gly Val Ser 
    50                  55                  60                  


Leu Cys Arg Pro Gly 
65                  


<210>  1097
<211>  45
<212>  PRT
<213>  Homo Sapiens

<400>  1097

Met Gly Pro Arg Gly Ala Ala Ser Leu Pro Arg Gly Pro Gly Pro Arg 
1               5                   10                  15      


Arg Leu Leu Leu Pro Val Val Leu Pro Leu Leu Leu Leu Leu Leu Leu 
            20                  25                  30          


Ala Pro Pro Gly Ser Gly Ala Gly Ala Ser Arg Pro Pro 
        35                  40                  45  


<210>  1098
<211>  533
<212>  PRT
<213>  Homo Sapiens

<400>  1098

Met Gly Pro Arg Gly Ala Ala Ser Leu Pro Arg Gly Pro Gly Pro Arg 
1               5                   10                  15      


Arg Leu Leu Leu Pro Val Val Leu Pro Leu Leu Leu Leu Leu Leu Leu 
            20                  25                  30          


Ala Pro Pro Gly Ser Gly Ala Gly Ala Ser Arg Pro Pro His Leu Val 
        35                  40                  45              


Phe Leu Leu Ala Asp Asp Leu Gly Trp Asn Asp Val Gly Phe His Gly 
    50                  55                  60                  


Ser Arg Ile Arg Thr Pro His Leu Asp Ala Leu Ala Ala Gly Gly Val 
65                  70                  75                  80  


Leu Leu Asp Asn Tyr Tyr Thr Gln Pro Leu Cys Thr Pro Ser Arg Ser 
                85                  90                  95      


Gln Leu Leu Thr Gly Arg Tyr Gln Ile Arg Thr Gly Leu Gln His Gln 
            100                 105                 110         


Ile Ile Trp Pro Cys Gln Pro Ser Cys Val Pro Leu Asp Glu Lys Leu 
        115                 120                 125             


Leu Pro Gln Leu Leu Lys Glu Ala Gly Tyr Thr Thr His Met Val Gly 
    130                 135                 140                 


Lys Trp His Leu Gly Met Tyr Arg Lys Glu Cys Leu Pro Thr Arg Arg 
145                 150                 155                 160 


Gly Phe Asp Thr Tyr Phe Gly Tyr Leu Leu Gly Ser Glu Asp Tyr Tyr 
                165                 170                 175     


Ser His Glu Arg Cys Thr Leu Ile Asp Ala Leu Asn Val Thr Arg Cys 
            180                 185                 190         


Ala Leu Asp Phe Arg Asp Gly Glu Glu Val Ala Thr Gly Tyr Lys Asn 
        195                 200                 205             


Met Tyr Ser Thr Asn Ile Phe Thr Lys Arg Ala Ile Ala Leu Ile Thr 
    210                 215                 220                 


Asn His Pro Pro Glu Lys Pro Leu Phe Leu Tyr Leu Ala Leu Gln Ser 
225                 230                 235                 240 


Val His Glu Pro Leu Gln Val Pro Glu Glu Tyr Leu Lys Pro Tyr Asp 
                245                 250                 255     


Phe Ile Gln Asp Lys Asn Arg His His Tyr Ala Gly Met Val Ser Leu 
            260                 265                 270         


Met Asp Glu Ala Val Gly Asn Val Thr Ala Ala Leu Lys Ser Ser Gly 
        275                 280                 285             


Leu Trp Asn Asn Thr Val Phe Ile Phe Ser Thr Asp Asn Gly Gly Gln 
    290                 295                 300                 


Thr Leu Ala Gly Gly Asn Asn Trp Pro Leu Arg Gly Arg Lys Trp Ser 
305                 310                 315                 320 


Leu Trp Glu Gly Gly Val Arg Gly Val Gly Phe Val Ala Ser Pro Leu 
                325                 330                 335     


Leu Lys Gln Lys Gly Val Lys Asn Arg Glu Leu Ile His Ile Ser Asp 
            340                 345                 350         


Trp Leu Pro Thr Leu Val Lys Leu Ala Arg Gly His Thr Asn Gly Thr 
        355                 360                 365             


Lys Pro Leu Asp Gly Phe Asp Val Trp Lys Thr Ile Ser Glu Gly Ser 
    370                 375                 380                 


Pro Ser Pro Arg Ile Glu Leu Leu His Asn Ile Asp Pro Asn Phe Val 
385                 390                 395                 400 


Asp Ser Ser Pro Cys Pro Arg Asn Ser Met Ala Pro Ala Lys Asp Asp 
                405                 410                 415     


Ser Ser Leu Pro Glu Tyr Ser Ala Phe Asn Thr Ser Val His Ala Ala 
            420                 425                 430         


Ile Arg His Gly Asn Trp Lys Leu Leu Thr Gly Tyr Pro Gly Cys Gly 
        435                 440                 445             


Tyr Trp Phe Pro Pro Pro Ser Gln Tyr Asn Val Ser Glu Ile Pro Ser 
    450                 455                 460                 


Ser Asp Pro Pro Thr Lys Thr Leu Trp Leu Phe Asp Ile Asp Arg Asp 
465                 470                 475                 480 


Pro Glu Glu Arg His Asp Leu Ser Arg Glu Tyr Pro His Ile Val Thr 
                485                 490                 495     


Lys Leu Leu Ser Arg Leu Gln Phe Tyr His Lys His Ser Val Pro Val 
            500                 505                 510         


Tyr Phe Pro Ala Gln Asp Pro Arg Cys Asp Pro Lys Ala Thr Gly Val 
        515                 520                 525             


Trp Gly Pro Trp Met 
    530             


<210>  1099
<211>  413
<212>  PRT
<213>  Homo Sapiens

<400>  1099

Met Gly Pro Arg Gly Ala Ala Ser Leu Pro Arg Gly Pro Gly Pro Arg 
1               5                   10                  15      


Arg Leu Leu Leu Pro Val Val Leu Pro Leu Leu Leu Leu Leu Leu Leu 
            20                  25                  30          


Ala Pro Pro Gly Ser Gly Ala Gly Ala Ser Arg Pro Pro His Leu Val 
        35                  40                  45              


Phe Leu Leu Ala Asp Asp Leu Gly Trp Asn Asp Val Gly Phe His Gly 
    50                  55                  60                  


Ser Arg Ile Arg Thr Pro His Leu Asp Ala Leu Ala Ala Gly Gly Val 
65                  70                  75                  80  


Leu Leu Asp Asn Tyr Tyr Thr Gln Pro Leu Cys Thr Pro Ser Arg Ser 
                85                  90                  95      


Gln Leu Leu Thr Gly Arg Tyr Gln Ile Arg Thr Gly Leu Gln His Gln 
            100                 105                 110         


Ile Ile Trp Pro Cys Gln Pro Ser Cys Val Pro Leu Asp Glu Lys Leu 
        115                 120                 125             


Leu Pro Gln Leu Leu Lys Glu Ala Gly Tyr Thr Thr His Met Val Gly 
    130                 135                 140                 


Lys Trp His Leu Gly Met Tyr Arg Lys Glu Cys Leu Pro Thr Arg Arg 
145                 150                 155                 160 


Gly Phe Asp Thr Tyr Phe Gly Tyr Leu Leu Gly Ser Glu Asp Tyr Tyr 
                165                 170                 175     


Ser His Glu Arg Cys Thr Leu Ile Asp Ala Leu Asn Val Thr Arg Cys 
            180                 185                 190         


Ala Leu Asp Phe Arg Asp Gly Glu Glu Val Ala Thr Gly Tyr Lys Asn 
        195                 200                 205             


Met Tyr Ser Thr Asn Ile Phe Thr Lys Arg Ala Ile Ala Leu Ile Thr 
    210                 215                 220                 


Asn His Pro Pro Glu Lys Pro Leu Phe Leu Tyr Leu Ala Leu Gln Ser 
225                 230                 235                 240 


Val His Glu Pro Leu Gln Val Pro Glu Glu Tyr Leu Lys Pro Tyr Asp 
                245                 250                 255     


Phe Ile Gln Asp Lys Asn Arg His His Tyr Ala Gly Met Val Ser Leu 
            260                 265                 270         


Met Asp Glu Ala Val Gly Asn Val Thr Ala Ala Leu Lys Ser Ser Gly 
        275                 280                 285             


Leu Trp Asn Asn Thr Val Phe Ile Phe Ser Thr Asp Asn Gly Gly Gln 
    290                 295                 300                 


Thr Leu Ala Gly Gly Asn Asn Trp Pro Leu Arg Gly Arg Lys Trp Ser 
305                 310                 315                 320 


Leu Trp Glu Gly Gly Val Arg Gly Val Gly Phe Val Ala Ser Pro Leu 
                325                 330                 335     


Leu Lys Gln Lys Gly Val Lys Asn Arg Glu Leu Ile His Ile Ser Asp 
            340                 345                 350         


Trp Leu Pro Thr Leu Val Lys Leu Ala Arg Gly His Thr Asn Gly Thr 
        355                 360                 365             


Lys Pro Leu Asp Gly Phe Asp Val Trp Lys Thr Ile Ser Glu Gly Ser 
    370                 375                 380                 


Pro Ser Pro Arg Ile Glu Leu Leu His Asn Ile Asp Pro Asn Phe Val 
385                 390                 395                 400 


Asp Ser Ser Pro Tyr Trp Pro Glu Cys Ser Leu Leu Leu 
                405                 410             


<210>  1100
<211>  398
<212>  PRT
<213>  Homo Sapiens

<400>  1100

Met Gly Pro Arg Gly Ala Ala Ser Leu Pro Arg Gly Pro Gly Pro Arg 
1               5                   10                  15      


Arg Leu Leu Leu Pro Val Val Leu Pro Leu Leu Leu Leu Leu Leu Leu 
            20                  25                  30          


Ala Pro Pro Gly Ser Gly Ala Gly Ala Ser Arg Pro Pro His Leu Val 
        35                  40                  45              


Phe Leu Leu Ala Asp Asp Leu Gly Trp Asn Asp Val Gly Phe His Gly 
    50                  55                  60                  


Ser Arg Ile Arg Thr Pro His Leu Asp Ala Leu Ala Ala Gly Gly Val 
65                  70                  75                  80  


Leu Leu Asp Asn Tyr Tyr Thr Gln Pro Leu Cys Thr Pro Ser Arg Ser 
                85                  90                  95      


Gln Leu Leu Thr Gly Arg Tyr Gln Ile Arg Thr Gly Leu Gln His Gln 
            100                 105                 110         


Ile Ile Trp Pro Cys Gln Pro Ser Cys Val Pro Leu Asp Glu Lys Leu 
        115                 120                 125             


Leu Pro Gln Leu Leu Lys Glu Ala Gly Tyr Thr Thr His Met Val Gly 
    130                 135                 140                 


Lys Trp His Leu Gly Met Tyr Arg Lys Glu Cys Leu Pro Thr Arg Arg 
145                 150                 155                 160 


Gly Phe Asp Thr Tyr Phe Gly Tyr Leu Leu Gly Ser Glu Asp Tyr Tyr 
                165                 170                 175     


Ser His Glu Arg Cys Thr Leu Ile Asp Ala Leu Asn Val Thr Arg Cys 
            180                 185                 190         


Ala Leu Asp Phe Arg Asp Gly Glu Glu Val Ala Thr Gly Tyr Lys Asn 
        195                 200                 205             


Met Tyr Ser Thr Asn Ile Phe Thr Lys Arg Ala Ile Ala Leu Ile Thr 
    210                 215                 220                 


Asn His Pro Pro Glu Lys Pro Leu Phe Leu Tyr Leu Ala Leu Gln Ser 
225                 230                 235                 240 


Val His Glu Pro Leu Gln Val Pro Glu Glu Tyr Leu Lys Pro Tyr Asp 
                245                 250                 255     


Phe Ile Gln Asp Lys Asn Arg His His Tyr Ala Gly Met Val Ser Leu 
            260                 265                 270         


Met Asp Glu Ala Val Gly Asn Val Thr Ala Ala Leu Lys Ser Ser Gly 
        275                 280                 285             


Leu Trp Asn Asn Thr Val Phe Ile Phe Ser Thr Asp Asn Gly Gly Gln 
    290                 295                 300                 


Thr Leu Ala Gly Gly Asn Asn Trp Pro Leu Arg Gly Arg Lys Trp Ser 
305                 310                 315                 320 


Leu Trp Glu Gly Gly Val Arg Gly Val Gly Phe Val Ala Ser Pro Leu 
                325                 330                 335     


Leu Lys Gln Lys Gly Val Lys Asn Arg Glu Leu Ile His Ile Ser Asp 
            340                 345                 350         


Trp Leu Pro Thr Leu Val Lys Leu Ala Arg Gly His Thr Asn Gly Thr 
        355                 360                 365             


Lys Pro Leu Asp Gly Phe Asp Val Trp Lys Thr Ile Arg Tyr Leu His 
    370                 375                 380                 


Pro Ala Leu Phe Pro Pro Arg Thr Glu Thr Pro Arg Ala Ala 
385                 390                 395             


<210>  1101
<211>  178
<212>  PRT
<213>  Homo Sapiens

<400>  1101

Met Leu His Leu His His Ser Cys Leu Cys Phe Arg Ser Trp Leu Pro 
1               5                   10                  15      


Ala Met Leu Ala Val Leu Leu Ser Leu Ala Pro Ser Ala Ser Ser Asp 
            20                  25                  30          


Ile Ser Ala Ser Arg Pro Asn Ile Leu Leu Leu Met Ala Asp Asp Leu 
        35                  40                  45              


Gly Ile Gly Asp Ile Gly Cys Tyr Gly Asn Asn Thr Met Arg Thr Pro 
    50                  55                  60                  


Asn Ile Asp Arg Leu Ala Glu Asp Gly Val Lys Leu Thr Gln His Ile 
65                  70                  75                  80  


Ser Ala Ala Ser Leu Cys Thr Pro Ser Arg Ala Ala Phe Leu Thr Gly 
                85                  90                  95      


Arg Tyr Pro Val Arg Ser Gly Met Val Ser Ser Ile Gly Tyr Arg Val 
            100                 105                 110         


Leu Gln Trp Thr Gly Ala Ser Gly Gly Leu Pro Thr Asn Glu Thr Thr 
        115                 120                 125             


Phe Ala Lys Ile Leu Lys Glu Lys Gly Tyr Ala Thr Gly Leu Ile Gly 
    130                 135                 140                 


Lys Trp His Leu Gly Leu Asn Cys Glu Ser Ala Ser Asp His Cys His 
145                 150                 155                 160 


His Pro Leu His His Gly Phe Asp His Phe Tyr Gly Met Pro Phe Ser 
                165                 170                 175     


Leu Met 
        


<210>  1102
<211>  589
<212>  PRT
<213>  Homo Sapiens

<400>  1102

Met Leu His Leu His His Ser Cys Leu Cys Phe Arg Ser Trp Leu Pro 
1               5                   10                  15      


Ala Met Leu Ala Val Leu Leu Ser Leu Ala Pro Ser Ala Ser Ser Asp 
            20                  25                  30          


Ile Ser Ala Ser Arg Pro Asn Ile Leu Leu Leu Met Ala Asp Asp Leu 
        35                  40                  45              


Gly Ile Gly Asp Ile Gly Cys Tyr Gly Asn Asn Thr Met Arg Thr Pro 
    50                  55                  60                  


Asn Ile Asp Arg Leu Ala Glu Asp Gly Val Lys Leu Thr Gln His Ile 
65                  70                  75                  80  


Ser Ala Ala Ser Leu Cys Thr Pro Ser Arg Ala Ala Phe Leu Thr Gly 
                85                  90                  95      


Arg Tyr Pro Val Arg Ser Gly Met Val Ser Ser Ile Gly Tyr Arg Val 
            100                 105                 110         


Leu Gln Trp Thr Gly Ala Ser Gly Gly Leu Pro Thr Asn Glu Thr Thr 
        115                 120                 125             


Phe Ala Lys Ile Leu Lys Glu Lys Gly Tyr Ala Thr Gly Leu Ile Gly 
    130                 135                 140                 


Lys Trp His Leu Gly Leu Asn Cys Glu Ser Ala Ser Asp His Cys His 
145                 150                 155                 160 


His Pro Leu His His Gly Phe Asp His Phe Tyr Gly Met Pro Phe Ser 
                165                 170                 175     


Leu Met Gly Asp Cys Ala Arg Trp Glu Leu Ser Glu Lys Arg Val Asn 
            180                 185                 190         


Leu Glu Gln Lys Leu Asn Phe Leu Phe Gln Val Leu Ala Leu Val Ala 
        195                 200                 205             


Leu Thr Leu Val Ala Gly Lys Leu Thr His Leu Ile Pro Val Ser Trp 
    210                 215                 220                 


Met Pro Val Ile Trp Ser Ala Leu Ser Ala Val Leu Leu Leu Ala Ser 
225                 230                 235                 240 


Ser Tyr Phe Val Gly Ala Leu Ile Val His Ala Asp Cys Phe Leu Met 
                245                 250                 255     


Arg Asn His Thr Ile Thr Glu Gln Pro Met Cys Phe Gln Arg Thr Thr 
            260                 265                 270         


Pro Leu Ile Leu Gln Glu Val Ala Ser Phe Leu Lys Arg Asn Lys His 
        275                 280                 285             


Gly Pro Phe Leu Leu Phe Val Ser Phe Leu His Val His Ile Pro Leu 
    290                 295                 300                 


Ile Thr Met Glu Asn Phe Leu Gly Lys Ser Leu His Gly Leu Tyr Gly 
305                 310                 315                 320 


Asp Asn Val Glu Glu Met Asp Trp Met Val Gly Arg Ile Leu Asp Thr 
                325                 330                 335     


Leu Asp Val Glu Gly Leu Ser Asn Ser Thr Leu Ile Tyr Phe Thr Ser 
            340                 345                 350         


Asp His Gly Gly Ser Leu Glu Asn Gln Leu Gly Asn Thr Gln Tyr Gly 
        355                 360                 365             


Gly Trp Asn Gly Ile Tyr Lys Gly Gly Lys Gly Met Gly Gly Trp Glu 
    370                 375                 380                 


Gly Gly Ile Arg Val Pro Gly Ile Phe Arg Trp Pro Gly Val Leu Pro 
385                 390                 395                 400 


Ala Gly Arg Val Ile Gly Glu Pro Thr Ser Leu Met Asp Val Phe Pro 
                405                 410                 415     


Thr Val Val Arg Leu Ala Gly Gly Glu Val Pro Gln Asp Arg Val Ile 
            420                 425                 430         


Asp Gly Gln Asp Leu Leu Pro Leu Leu Leu Gly Thr Ala Gln His Ser 
        435                 440                 445             


Asp His Glu Phe Leu Met His Tyr Cys Glu Arg Phe Leu His Ala Ala 
    450                 455                 460                 


Arg Trp His Gln Arg Asp Arg Gly Thr Met Trp Lys Val His Phe Val 
465                 470                 475                 480 


Thr Pro Val Phe Gln Pro Glu Gly Ala Gly Ala Cys Tyr Gly Arg Lys 
                485                 490                 495     


Val Cys Pro Cys Phe Gly Glu Lys Val Val His His Asp Pro Pro Leu 
            500                 505                 510         


Leu Phe Asp Leu Ser Arg Asp Pro Ser Glu Thr His Ile Leu Thr Pro 
        515                 520                 525             


Ala Ser Glu Pro Val Phe Tyr Gln Val Met Glu Arg Val Gln Gln Ala 
    530                 535                 540                 


Val Trp Glu His Gln Arg Thr Leu Ser Pro Val Pro Leu Gln Leu Asp 
545                 550                 555                 560 


Arg Leu Gly Asn Ile Trp Arg Pro Trp Leu Gln Pro Cys Cys Gly Pro 
                565                 570                 575     


Phe Pro Leu Cys Trp Cys Leu Arg Glu Asp Asp Pro Gln 
            580                 585                 


<210>  1103
<211>  614
<212>  PRT
<213>  Homo Sapiens

<400>  1103

Met Arg Pro Val Ile Asn Arg Cys Ala Pro Gly Ser Leu Asp Leu Met 
1               5                   10                  15      


Leu Pro Gln Ala Ala Ser Glu Gly Ile Val Phe His Ser Leu Gln Ile 
            20                  25                  30          


Ser Leu Cys Phe Arg Ser Trp Leu Pro Ala Met Leu Ala Val Leu Leu 
        35                  40                  45              


Ser Leu Ala Pro Ser Ala Ser Ser Asp Ile Ser Ala Ser Arg Pro Asn 
    50                  55                  60                  


Ile Leu Leu Leu Met Ala Asp Asp Leu Gly Ile Gly Asp Ile Gly Cys 
65                  70                  75                  80  


Tyr Gly Asn Asn Thr Met Arg Thr Pro Asn Ile Asp Arg Leu Ala Glu 
                85                  90                  95      


Asp Gly Val Lys Leu Thr Gln His Ile Ser Ala Ala Ser Leu Cys Thr 
            100                 105                 110         


Pro Ser Arg Ala Ala Phe Leu Thr Gly Arg Tyr Pro Val Arg Ser Gly 
        115                 120                 125             


Met Val Ser Ser Ile Gly Tyr Arg Val Leu Gln Trp Thr Gly Ala Ser 
    130                 135                 140                 


Gly Gly Leu Pro Thr Asn Glu Thr Thr Phe Ala Lys Ile Leu Lys Glu 
145                 150                 155                 160 


Lys Gly Tyr Ala Thr Gly Leu Ile Gly Lys Trp His Leu Gly Leu Asn 
                165                 170                 175     


Cys Glu Ser Ala Ser Asp His Cys His His Pro Leu His His Gly Phe 
            180                 185                 190         


Asp His Phe Tyr Gly Met Pro Phe Ser Leu Met Gly Asp Cys Ala Arg 
        195                 200                 205             


Trp Glu Leu Ser Glu Lys Arg Val Asn Leu Glu Gln Lys Leu Asn Phe 
    210                 215                 220                 


Leu Phe Gln Val Leu Ala Leu Val Ala Leu Thr Leu Val Ala Gly Lys 
225                 230                 235                 240 


Leu Thr His Leu Ile Pro Val Ser Trp Met Pro Val Ile Trp Ser Ala 
                245                 250                 255     


Leu Ser Ala Val Leu Leu Leu Ala Ser Ser Tyr Phe Val Gly Ala Leu 
            260                 265                 270         


Ile Val His Ala Asp Cys Phe Leu Met Arg Asn His Thr Ile Thr Glu 
        275                 280                 285             


Gln Pro Met Cys Phe Gln Arg Thr Thr Pro Leu Ile Leu Gln Glu Val 
    290                 295                 300                 


Ala Ser Phe Leu Lys Arg Asn Lys His Gly Pro Phe Leu Leu Phe Val 
305                 310                 315                 320 


Ser Phe Leu His Val His Ile Pro Leu Ile Thr Met Glu Asn Phe Leu 
                325                 330                 335     


Gly Lys Ser Leu His Gly Leu Tyr Gly Asp Asn Val Glu Glu Met Asp 
            340                 345                 350         


Trp Met Val Gly Arg Ile Leu Asp Thr Leu Asp Val Glu Gly Leu Ser 
        355                 360                 365             


Asn Ser Thr Leu Ile Tyr Phe Thr Ser Asp His Gly Gly Ser Leu Glu 
    370                 375                 380                 


Asn Gln Leu Gly Asn Thr Gln Tyr Gly Gly Trp Asn Gly Ile Tyr Lys 
385                 390                 395                 400 


Gly Gly Lys Gly Met Gly Gly Trp Glu Gly Gly Ile Arg Val Pro Gly 
                405                 410                 415     


Ile Phe Arg Trp Pro Gly Val Leu Pro Ala Gly Arg Val Ile Gly Glu 
            420                 425                 430         


Pro Thr Ser Leu Met Asp Val Phe Pro Thr Val Val Arg Leu Ala Gly 
        435                 440                 445             


Gly Glu Val Pro Gln Asp Arg Val Ile Asp Gly Gln Asp Leu Leu Pro 
    450                 455                 460                 


Leu Leu Leu Gly Thr Ala Gln His Ser Asp His Glu Phe Leu Met His 
465                 470                 475                 480 


Tyr Cys Glu Arg Phe Leu His Ala Ala Arg Trp His Gln Arg Asp Arg 
                485                 490                 495     


Gly Thr Met Trp Lys Val His Phe Val Thr Pro Val Phe Gln Pro Glu 
            500                 505                 510         


Gly Ala Gly Ala Cys Tyr Gly Arg Lys Val Cys Pro Cys Phe Gly Glu 
        515                 520                 525             


Lys Val Val His His Asp Pro Pro Leu Leu Phe Asp Leu Ser Arg Asp 
    530                 535                 540                 


Pro Ser Glu Thr His Ile Leu Thr Pro Ala Ser Glu Pro Val Phe Tyr 
545                 550                 555                 560 


Gln Val Met Glu Arg Val Gln Gln Ala Val Trp Glu His Gln Arg Thr 
                565                 570                 575     


Leu Ser Pro Val Pro Leu Gln Leu Asp Arg Leu Gly Asn Ile Trp Arg 
            580                 585                 590         


Pro Trp Leu Gln Pro Cys Cys Gly Pro Phe Pro Leu Cys Trp Cys Leu 
        595                 600                 605             


Arg Glu Asp Asp Pro Gln 
    610                 


<210>  1104
<211>  544
<212>  PRT
<213>  Homo Sapiens

<400>  1104

Met Ser Gly Ser Arg Glu Arg Asp Asn Met Leu His Leu His His Ser 
1               5                   10                  15      


Trp Thr Pro Asn Ile Asp Arg Leu Ala Glu Asp Gly Val Lys Leu Thr 
            20                  25                  30          


Gln His Ile Ser Ala Ala Ser Leu Cys Thr Pro Ser Arg Ala Ala Phe 
        35                  40                  45              


Leu Thr Gly Arg Tyr Pro Val Arg Ser Gly Met Val Ser Ser Ile Gly 
    50                  55                  60                  


Tyr Arg Val Leu Gln Trp Thr Gly Ala Ser Gly Gly Leu Pro Thr Asn 
65                  70                  75                  80  


Glu Thr Thr Phe Ala Lys Ile Leu Lys Glu Lys Gly Tyr Ala Thr Gly 
                85                  90                  95      


Leu Ile Gly Lys Trp His Leu Gly Leu Asn Cys Glu Ser Ala Ser Asp 
            100                 105                 110         


His Cys His His Pro Leu His His Gly Phe Asp His Phe Tyr Gly Met 
        115                 120                 125             


Pro Phe Ser Leu Met Gly Asp Cys Ala Arg Trp Glu Leu Ser Glu Lys 
    130                 135                 140                 


Arg Val Asn Leu Glu Gln Lys Leu Asn Phe Leu Phe Gln Val Leu Ala 
145                 150                 155                 160 


Leu Val Ala Leu Thr Leu Val Ala Gly Lys Leu Thr His Leu Ile Pro 
                165                 170                 175     


Val Ser Trp Met Pro Val Ile Trp Ser Ala Leu Ser Ala Val Leu Leu 
            180                 185                 190         


Leu Ala Ser Ser Tyr Phe Val Gly Ala Leu Ile Val His Ala Asp Cys 
        195                 200                 205             


Phe Leu Met Arg Asn His Thr Ile Thr Glu Gln Pro Met Cys Phe Gln 
    210                 215                 220                 


Arg Thr Thr Pro Leu Ile Leu Gln Glu Val Ala Ser Phe Leu Lys Arg 
225                 230                 235                 240 


Asn Lys His Gly Pro Phe Leu Leu Phe Val Ser Phe Leu His Val His 
                245                 250                 255     


Ile Pro Leu Ile Thr Met Glu Asn Phe Leu Gly Lys Ser Leu His Gly 
            260                 265                 270         


Leu Tyr Gly Asp Asn Val Glu Glu Met Asp Trp Met Val Gly Arg Ile 
        275                 280                 285             


Leu Asp Thr Leu Asp Val Glu Gly Leu Ser Asn Ser Thr Leu Ile Tyr 
    290                 295                 300                 


Phe Thr Ser Asp His Gly Gly Ser Leu Glu Asn Gln Leu Gly Asn Thr 
305                 310                 315                 320 


Gln Tyr Gly Gly Trp Asn Gly Ile Tyr Lys Gly Gly Lys Gly Met Gly 
                325                 330                 335     


Gly Trp Glu Gly Gly Ile Arg Val Pro Gly Ile Phe Arg Trp Pro Gly 
            340                 345                 350         


Val Leu Pro Ala Gly Arg Val Ile Gly Glu Pro Thr Ser Leu Met Asp 
        355                 360                 365             


Val Phe Pro Thr Val Val Arg Leu Ala Gly Gly Glu Val Pro Gln Asp 
    370                 375                 380                 


Arg Val Ile Asp Gly Gln Asp Leu Leu Pro Leu Leu Leu Gly Thr Ala 
385                 390                 395                 400 


Gln His Ser Asp His Glu Phe Leu Met His Tyr Cys Glu Arg Phe Leu 
                405                 410                 415     


His Ala Ala Arg Trp His Gln Arg Asp Arg Gly Thr Met Trp Lys Val 
            420                 425                 430         


His Phe Val Thr Pro Val Phe Gln Pro Glu Gly Ala Gly Ala Cys Tyr 
        435                 440                 445             


Gly Arg Lys Val Cys Pro Cys Phe Gly Glu Lys Val Val His His Asp 
    450                 455                 460                 


Pro Pro Leu Leu Phe Asp Leu Ser Arg Asp Pro Ser Glu Thr His Ile 
465                 470                 475                 480 


Leu Thr Pro Ala Ser Glu Pro Val Phe Tyr Gln Val Met Glu Arg Val 
                485                 490                 495     


Gln Gln Ala Val Trp Glu His Gln Arg Thr Leu Ser Pro Val Pro Leu 
            500                 505                 510         


Gln Leu Asp Arg Leu Gly Asn Ile Trp Arg Pro Trp Leu Gln Pro Cys 
        515                 520                 525             


Cys Gly Pro Phe Pro Leu Cys Trp Cys Leu Arg Glu Asp Asp Pro Gln 
    530                 535                 540                 


<210>  1105
<211>  361
<212>  PRT
<213>  Homo Sapiens

<400>  1105

Met Gly Cys Thr Asp Thr Pro Gly Tyr Asn His Pro Pro Cys Pro Ala 
1               5                   10                  15      


Cys Pro Gln Gly Asp Gly Pro Ser Arg Asn Leu Gln Arg Asp Cys Tyr 
            20                  25                  30          


Thr Asp Val Ala Leu Pro Leu Tyr Glu Asn Leu Asn Ile Val Glu Gln 
        35                  40                  45              


Pro Val Asn Leu Ser Ser Leu Ala Gln Lys Tyr Ala Glu Lys Ala Thr 
    50                  55                  60                  


Gln Phe Ile Gln Arg Ala Ser Thr Ser Gly Arg Pro Phe Leu Leu Tyr 
65                  70                  75                  80  


Val Ala Leu Ala His Met His Val Pro Leu Pro Val Thr Gln Leu Pro 
                85                  90                  95      


Ala Ala Pro Arg Gly Arg Ser Leu Tyr Gly Ala Gly Leu Trp Glu Met 
            100                 105                 110         


Asp Ser Leu Val Gly Gln Ile Lys Asp Lys Val Asp His Thr Val Lys 
        115                 120                 125             


Glu Asn Thr Phe Leu Trp Phe Thr Gly Asp Asn Gly Pro Trp Ala Gln 
    130                 135                 140                 


Lys Cys Glu Leu Ala Gly Ser Val Gly Pro Phe Thr Gly Phe Trp Gln 
145                 150                 155                 160 


Thr Arg Gln Gly Gly Ser Pro Ala Lys Gln Thr Thr Trp Glu Gly Gly 
                165                 170                 175     


His Arg Val Pro Ala Leu Ala Tyr Trp Pro Gly Arg Val Pro Val Asn 
            180                 185                 190         


Val Thr Ser Thr Ala Leu Leu Ser Val Leu Asp Ile Phe Pro Thr Val 
        195                 200                 205             


Val Ala Leu Ala Gln Ala Ser Leu Pro Gln Gly Arg Arg Phe Asp Gly 
    210                 215                 220                 


Val Asp Val Ser Glu Val Leu Phe Gly Arg Ser Gln Pro Gly His Arg 
225                 230                 235                 240 


Val Leu Phe His Pro Asn Ser Gly Ala Ala Gly Glu Phe Gly Ala Leu 
                245                 250                 255     


Gln Thr Val Arg Leu Glu Arg Tyr Lys Ala Phe Tyr Ile Thr Gly Gly 
            260                 265                 270         


Ala Arg Ala Cys Asp Gly Ser Thr Gly Pro Glu Leu Gln His Lys Phe 
        275                 280                 285             


Pro Leu Ile Phe Asn Leu Glu Asp Asp Thr Ala Glu Ala Val Pro Leu 
    290                 295                 300                 


Glu Arg Gly Gly Ala Glu Tyr Gln Ala Val Leu Pro Glu Val Arg Lys 
305                 310                 315                 320 


Val Leu Ala Asp Val Leu Gln Asp Ile Ala Asn Asp Asn Ile Ser Ser 
                325                 330                 335     


Ala Asp Tyr Thr Gln Asp Pro Ser Val Thr Pro Cys Cys Asn Pro Tyr 
            340                 345                 350         


Gln Ile Ala Cys Arg Cys Gln Ala Ala 
        355                 360     


<210>  1106
<211>  29
<212>  PRT
<213>  Homo Sapiens

<400>  1106

Met Gly Trp Leu Phe Leu Lys Val Leu Leu Ala Gly Val Ser Phe Ser 
1               5                   10                  15      


Gly Phe Leu Tyr Pro Leu Val Asp Phe Cys Ile Ser Gly 
            20                  25                  


<210>  1107
<211>  525
<212>  PRT
<213>  Homo Sapiens

<400>  1107

Met Gly Trp Leu Phe Leu Lys Val Leu Leu Ala Gly Val Ser Phe Ser 
1               5                   10                  15      


Gly Phe Leu Tyr Pro Leu Val Asp Phe Cys Ile Ser Gly Lys Thr Arg 
            20                  25                  30          


Gly Gln Lys Pro Asn Phe Val Ile Ile Leu Ala Asp Asp Met Gly Trp 
        35                  40                  45              


Gly Asp Leu Gly Ala Asn Trp Ala Glu Thr Lys Asp Thr Ala Asn Leu 
    50                  55                  60                  


Asp Lys Met Ala Ser Glu Gly Met Arg Phe Val Asp Phe His Ala Ala 
65                  70                  75                  80  


Ala Ser Thr Cys Ser Pro Ser Arg Ala Ser Leu Leu Thr Gly Arg Leu 
                85                  90                  95      


Gly Leu Arg Asn Gly Val Thr Arg Asn Phe Ala Val Thr Ser Val Gly 
            100                 105                 110         


Gly Leu Pro Leu Asn Glu Thr Thr Leu Ala Glu Val Leu Gln Gln Ala 
        115                 120                 125             


Gly Tyr Val Thr Gly Ile Ile Gly Lys Trp His Leu Gly His His Gly 
    130                 135                 140                 


Ser Tyr His Pro Asn Phe Arg Gly Phe Asp Tyr Tyr Phe Gly Ile Pro 
145                 150                 155                 160 


Tyr Ser His Asp Met Gly Cys Thr Asp Thr Pro Gly Tyr Asn His Pro 
                165                 170                 175     


Pro Cys Pro Ala Cys Pro Gln Gly Asp Gly Pro Ser Arg Asn Leu Gln 
            180                 185                 190         


Arg Asp Cys Tyr Thr Asp Val Ala Leu Pro Leu Tyr Glu Asn Leu Asn 
        195                 200                 205             


Ile Val Glu Gln Pro Val Asn Leu Ser Ser Leu Ala Gln Lys Tyr Ala 
    210                 215                 220                 


Glu Lys Ala Thr Gln Phe Ile Gln Arg Ala Ser Thr Ser Gly Arg Pro 
225                 230                 235                 240 


Phe Leu Leu Tyr Val Ala Leu Ala His Met His Val Pro Leu Pro Val 
                245                 250                 255     


Thr Gln Leu Pro Ala Ala Pro Arg Gly Arg Ser Leu Tyr Gly Ala Gly 
            260                 265                 270         


Leu Trp Glu Met Asp Ser Leu Val Gly Gln Ile Lys Asp Lys Val Asp 
        275                 280                 285             


His Thr Val Lys Glu Asn Thr Phe Leu Trp Phe Thr Gly Asp Asn Gly 
    290                 295                 300                 


Pro Trp Ala Gln Lys Cys Glu Leu Ala Gly Ser Val Gly Pro Phe Thr 
305                 310                 315                 320 


Gly Phe Trp Gln Thr Arg Gln Gly Gly Ser Pro Ala Lys Gln Thr Thr 
                325                 330                 335     


Trp Glu Gly Gly His Arg Val Pro Ala Leu Ala Tyr Trp Pro Gly Arg 
            340                 345                 350         


Val Pro Val Asn Val Thr Ser Thr Ala Leu Leu Ser Val Leu Asp Ile 
        355                 360                 365             


Phe Pro Thr Val Val Ala Leu Ala Gln Ala Ser Leu Pro Gln Gly Arg 
    370                 375                 380                 


Arg Phe Asp Gly Val Asp Val Ser Glu Val Leu Phe Gly Arg Ser Gln 
385                 390                 395                 400 


Pro Gly His Arg Val Leu Phe His Pro Asn Ser Gly Ala Ala Gly Glu 
                405                 410                 415     


Phe Gly Ala Leu Gln Thr Val Arg Leu Glu Arg Tyr Lys Ala Phe Tyr 
            420                 425                 430         


Ile Thr Gly Gly Ala Arg Ala Cys Asp Gly Ser Thr Gly Pro Glu Leu 
        435                 440                 445             


Gln His Lys Phe Pro Leu Ile Phe Asn Leu Glu Asp Asp Thr Ala Glu 
    450                 455                 460                 


Ala Val Pro Leu Glu Arg Gly Gly Ala Glu Tyr Gln Ala Val Leu Pro 
465                 470                 475                 480 


Glu Val Arg Lys Val Leu Ala Asp Val Leu Gln Asp Ile Ala Asn Asp 
                485                 490                 495     


Asn Ile Ser Ser Ala Asp Tyr Thr Gln Asp Pro Ser Val Thr Pro Cys 
            500                 505                 510         


Cys Asn Pro Tyr Gln Ile Ala Cys Arg Cys Gln Ala Ala 
        515                 520                 525 


<210>  1108
<211>  525
<212>  PRT
<213>  Homo Sapiens

<400>  1108

Met Gly Trp Leu Phe Leu Lys Val Leu Leu Ala Gly Val Ser Phe Ser 
1               5                   10                  15      


Gly Phe Leu Tyr Pro Leu Val Asp Phe Cys Ile Ser Gly Lys Thr Arg 
            20                  25                  30          


Gly Gln Lys Pro Asn Phe Val Ile Ile Leu Ala Asp Asp Met Gly Trp 
        35                  40                  45              


Gly Asp Leu Gly Ala Asn Trp Ala Glu Thr Lys Asp Thr Ala Asn Leu 
    50                  55                  60                  


Asp Lys Met Ala Ser Glu Gly Met Arg Phe Val Asp Phe His Ala Ala 
65                  70                  75                  80  


Ala Ser Thr Cys Ser Pro Ser Arg Ala Ser Leu Leu Thr Gly Arg Leu 
                85                  90                  95      


Gly Leu Arg Asn Gly Val Thr Arg Asn Phe Ala Val Thr Ser Val Gly 
            100                 105                 110         


Gly Leu Pro Leu Asn Glu Thr Thr Leu Ala Glu Val Leu Gln Gln Ala 
        115                 120                 125             


Gly Tyr Val Thr Gly Ile Ile Gly Lys Trp His Leu Gly His His Gly 
    130                 135                 140                 


Ser Tyr His Pro Asn Phe Arg Gly Phe Asp Tyr Tyr Phe Gly Ile Pro 
145                 150                 155                 160 


Tyr Ser His Asp Met Gly Cys Thr Asp Thr Pro Gly Tyr Asn His Pro 
                165                 170                 175     


Pro Cys Pro Ala Cys Pro Gln Gly Asp Gly Pro Ser Arg Asn Leu Gln 
            180                 185                 190         


Arg Asp Cys Tyr Thr Asp Val Ala Leu Pro Leu Tyr Glu Asn Leu Asn 
        195                 200                 205             


Ile Val Glu Gln Pro Val Asn Leu Ser Ser Leu Ala Gln Lys Tyr Ala 
    210                 215                 220                 


Glu Lys Ala Thr Gln Phe Ile Gln Arg Ala Ser Thr Ser Gly Arg Pro 
225                 230                 235                 240 


Phe Leu Leu Tyr Val Ala Leu Ala His Met His Val Pro Leu Pro Val 
                245                 250                 255     


Thr Gln Leu Pro Ala Ala Pro Arg Gly Arg Ser Leu Tyr Gly Ala Gly 
            260                 265                 270         


Leu Trp Glu Met Asp Ser Leu Val Gly Gln Ile Lys Asp Lys Val Asp 
        275                 280                 285             


His Thr Val Lys Glu Asn Thr Phe Leu Trp Phe Thr Gly Asp Asn Gly 
    290                 295                 300                 


Pro Trp Ala Gln Lys Cys Glu Leu Ala Gly Ser Val Gly Pro Phe Thr 
305                 310                 315                 320 


Gly Phe Trp Gln Thr Arg Gln Gly Gly Ser Pro Ala Lys Gln Thr Thr 
                325                 330                 335     


Trp Glu Gly Gly His Arg Val Pro Ala Leu Ala Tyr Trp Pro Gly Arg 
            340                 345                 350         


Val Pro Val Asn Val Thr Ser Thr Ala Leu Leu Ser Val Leu Asp Ile 
        355                 360                 365             


Phe Pro Thr Val Val Ala Leu Ala Gln Ala Ser Leu Pro Gln Gly Arg 
    370                 375                 380                 


Arg Phe Asp Gly Val Asp Val Ser Glu Val Leu Phe Gly Arg Ser Gln 
385                 390                 395                 400 


Pro Gly His Arg Val Leu Phe His Pro Asn Ser Gly Ala Ala Gly Glu 
                405                 410                 415     


Phe Gly Ala Leu Gln Thr Val Arg Leu Glu Arg Tyr Lys Ala Phe Tyr 
            420                 425                 430         


Ile Thr Gly Gly Ala Arg Ala Cys Asp Gly Ser Thr Gly Pro Glu Leu 
        435                 440                 445             


Gln His Lys Phe Pro Leu Ile Phe Asn Leu Glu Asp Asp Thr Ala Glu 
    450                 455                 460                 


Ala Val Pro Leu Glu Arg Gly Gly Ala Glu Tyr Gln Ala Val Leu Pro 
465                 470                 475                 480 


Glu Val Arg Lys Val Leu Ala Asp Val Leu Gln Asp Ile Ala Asn Asp 
                485                 490                 495     


Asn Ile Ser Ser Ala Asp Tyr Thr Gln Asp Pro Ser Val Thr Pro Cys 
            500                 505                 510         


Cys Asn Pro Tyr Gln Ile Ala Cys Arg Cys Gln Ala Ala 
        515                 520                 525 


<210>  1109
<211>  569
<212>  PRT
<213>  Homo Sapiens

<400>  1109

Met His Thr Leu Thr Gly Phe Ser Leu Val Ser Leu Leu Ser Phe Gly 
1               5                   10                  15      


Tyr Leu Ser Trp Asp Trp Ala Lys Pro Ser Phe Val Ala Asp Gly Pro 
            20                  25                  30          


Gly Glu Ala Gly Glu Gln Pro Ser Ala Ala Pro Pro Gln Pro Pro His 
        35                  40                  45              


Ile Ile Phe Ile Leu Thr Asp Asp Gln Gly Tyr His Asp Val Gly Tyr 
    50                  55                  60                  


His Gly Ser Asp Ile Glu Thr Pro Thr Leu Asp Arg Leu Ala Ala Lys 
65                  70                  75                  80  


Gly Val Lys Leu Glu Asn Tyr Tyr Ile Gln Pro Ile Cys Thr Pro Ser 
                85                  90                  95      


Arg Ser Gln Leu Leu Thr Gly Arg Tyr Gln Ile His Thr Gly Leu Gln 
            100                 105                 110         


His Ser Ile Ile Arg Pro Gln Gln Pro Asn Cys Leu Pro Leu Asp Gln 
        115                 120                 125             


Val Thr Leu Pro Gln Lys Leu Gln Glu Ala Gly Tyr Ser Thr His Met 
    130                 135                 140                 


Val Gly Lys Trp His Leu Gly Phe Tyr Arg Lys Glu Cys Leu Pro Thr 
145                 150                 155                 160 


Arg Arg Gly Phe Asp Thr Phe Leu Gly Ser Leu Thr Gly Asn Val Asp 
                165                 170                 175     


Tyr Tyr Thr Tyr Asp Asn Cys Asp Gly Pro Gly Val Cys Gly Phe Asp 
            180                 185                 190         


Leu His Glu Gly Glu Asn Val Ala Trp Gly Leu Ser Gly Gln Tyr Ser 
        195                 200                 205             


Thr Met Leu Tyr Ala Gln Arg Ala Ser His Ile Leu Ala Ser His Ser 
    210                 215                 220                 


Pro Gln Arg Pro Leu Phe Leu Tyr Val Ala Phe Gln Ala Val His Thr 
225                 230                 235                 240 


Pro Leu Gln Ser Pro Arg Glu Tyr Leu Tyr Arg Tyr Arg Thr Met Gly 
                245                 250                 255     


Asn Val Ala Arg Arg Lys Tyr Ala Ala Met Val Thr Cys Met Asp Glu 
            260                 265                 270         


Ala Val Arg Asn Ile Thr Trp Ala Leu Lys Arg Tyr Gly Phe Tyr Asn 
        275                 280                 285             


Asn Ser Val Ile Ile Phe Ser Ser Asp Asn Gly Gly Gln Thr Phe Ser 
    290                 295                 300                 


Gly Gly Ser Asn Trp Pro Leu Arg Gly Arg Lys Gly Thr Tyr Trp Glu 
305                 310                 315                 320 


Gly Gly Val Arg Gly Leu Gly Phe Val His Ser Pro Leu Leu Lys Arg 
                325                 330                 335     


Lys Gln Arg Thr Ser Arg Ala Leu Met His Ile Thr Asp Trp Tyr Pro 
            340                 345                 350         


Thr Leu Val Gly Leu Ala Gly Gly Thr Thr Ser Ala Ala Asp Gly Leu 
        355                 360                 365             


Asp Gly Tyr Asp Val Trp Pro Ala Ile Ser Glu Gly Arg Ala Ser Pro 
    370                 375                 380                 


Arg Thr Glu Ile Leu His Asn Ile Asp Pro Leu Tyr Asn His Ala Gln 
385                 390                 395                 400 


His Gly Ser Leu Glu Gly Gly Phe Gly Ile Trp Asn Thr Ala Val Gln 
                405                 410                 415     


Ala Ala Ile Arg Val Gly Glu Trp Lys Leu Leu Thr Gly Asp Pro Gly 
            420                 425                 430         


Tyr Gly Asp Trp Ile Pro Pro Gln Thr Leu Ala Thr Phe Pro Gly Ser 
        435                 440                 445             


Trp Trp Asn Leu Glu Arg Met Ala Ser Val Arg Gln Ala Val Trp Leu 
    450                 455                 460                 


Phe Asn Ile Ser Ala Asp Pro Tyr Glu Arg Glu Asp Leu Ala Gly Gln 
465                 470                 475                 480 


Arg Pro Asp Val Val Arg Thr Leu Leu Ala Arg Leu Ala Glu Tyr Asn 
                485                 490                 495     


Arg Thr Ala Ile Pro Val Arg Tyr Pro Ala Glu Asn Pro Arg Ala His 
            500                 505                 510         


Pro Asp Phe Asn Gly Gly Ala Trp Gly Pro Trp Ala Ser Asp Glu Glu 
        515                 520                 525             


Glu Glu Glu Glu Glu Gly Arg Ala Arg Ser Phe Ser Arg Gly Arg Arg 
    530                 535                 540                 


Lys Lys Lys Cys Lys Ile Cys Lys Leu Arg Ser Phe Phe Arg Lys Leu 
545                 550                 555                 560 


Asn Thr Arg Leu Met Ser Gln Arg Ile 
                565                 


<210>  1110
<211>  86
<212>  PRT
<213>  Homo Sapiens

<400>  1110

Met Val Gly Lys Trp His Leu Gly Phe Tyr Arg Lys Glu Cys Leu Pro 
1               5                   10                  15      


Thr Arg Arg Gly Phe Asp Thr Phe Leu Gly Ser Leu Thr Gly Asn Val 
            20                  25                  30          


Asp Tyr Tyr Thr Tyr Asp Asn Cys Asp Gly Pro Gly Val Cys Gly Phe 
        35                  40                  45              


Asp Leu His Glu Gly Glu Asn Val Ala Trp Gly Leu Ser Gly Gln Tyr 
    50                  55                  60                  


Ser Thr Met Leu Tyr Ala Gln Arg Ala Ser His Ile Leu Ala Ser His 
65                  70                  75                  80  


Ser Pro Gln Arg Pro Leu 
                85      


<210>  1111
<211>  426
<212>  PRT
<213>  Homo Sapiens

<400>  1111

Met Val Gly Lys Trp His Leu Gly Phe Tyr Arg Lys Glu Cys Leu Pro 
1               5                   10                  15      


Thr Arg Arg Gly Phe Asp Thr Phe Leu Gly Ser Leu Thr Gly Asn Val 
            20                  25                  30          


Asp Tyr Tyr Thr Tyr Asp Asn Cys Asp Gly Pro Gly Val Cys Gly Phe 
        35                  40                  45              


Asp Leu His Glu Gly Glu Asn Val Ala Trp Gly Leu Ser Gly Gln Tyr 
    50                  55                  60                  


Ser Thr Met Leu Tyr Ala Gln Arg Ala Ser His Ile Leu Ala Ser His 
65                  70                  75                  80  


Ser Pro Gln Arg Pro Leu Phe Leu Tyr Val Ala Phe Gln Ala Val His 
                85                  90                  95      


Thr Pro Leu Gln Ser Pro Arg Glu Tyr Leu Tyr Arg Tyr Arg Thr Met 
            100                 105                 110         


Gly Asn Val Ala Arg Arg Lys Tyr Ala Ala Met Val Thr Cys Met Asp 
        115                 120                 125             


Glu Ala Val Arg Asn Ile Thr Trp Ala Leu Lys Arg Tyr Gly Phe Tyr 
    130                 135                 140                 


Asn Asn Ser Val Ile Ile Phe Ser Ser Asp Asn Gly Gly Gln Thr Phe 
145                 150                 155                 160 


Ser Gly Gly Ser Asn Trp Pro Leu Arg Gly Arg Lys Gly Thr Tyr Trp 
                165                 170                 175     


Glu Gly Gly Val Arg Gly Leu Gly Phe Val His Ser Pro Leu Leu Lys 
            180                 185                 190         


Arg Lys Gln Arg Thr Ser Arg Ala Leu Met His Ile Thr Asp Trp Tyr 
        195                 200                 205             


Pro Thr Leu Val Gly Leu Ala Gly Gly Thr Thr Ser Ala Ala Asp Gly 
    210                 215                 220                 


Leu Asp Gly Tyr Asp Val Trp Pro Ala Ile Ser Glu Gly Arg Ala Ser 
225                 230                 235                 240 


Pro Arg Thr Glu Ile Leu His Asn Ile Asp Pro Leu Tyr Asn His Ala 
                245                 250                 255     


Gln His Gly Ser Leu Glu Gly Gly Phe Gly Ile Trp Asn Thr Ala Val 
            260                 265                 270         


Gln Ala Ala Ile Arg Val Gly Glu Trp Lys Leu Leu Thr Gly Asp Pro 
        275                 280                 285             


Gly Tyr Gly Asp Trp Ile Pro Pro Gln Thr Leu Ala Thr Phe Pro Gly 
    290                 295                 300                 


Ser Trp Trp Asn Leu Glu Arg Met Ala Ser Val Arg Gln Ala Val Trp 
305                 310                 315                 320 


Leu Phe Asn Ile Ser Ala Asp Pro Tyr Glu Arg Glu Asp Leu Ala Gly 
                325                 330                 335     


Gln Arg Pro Asp Val Val Arg Thr Leu Leu Ala Arg Leu Ala Glu Tyr 
            340                 345                 350         


Asn Arg Thr Ala Ile Pro Val Arg Tyr Pro Ala Glu Asn Pro Arg Ala 
        355                 360                 365             


His Pro Asp Phe Asn Gly Gly Ala Trp Gly Pro Trp Ala Ser Asp Glu 
    370                 375                 380                 


Glu Glu Glu Glu Glu Glu Gly Arg Ala Arg Ser Phe Ser Arg Gly Arg 
385                 390                 395                 400 


Arg Lys Lys Lys Cys Lys Ile Cys Lys Leu Arg Ser Phe Phe Arg Lys 
                405                 410                 415     


Leu Asn Thr Arg Leu Met Ser Gln Arg Ile 
            420                 425     


<210>  1112
<211>  153
<212>  PRT
<213>  Homo Sapiens

<400>  1112

Met Leu Leu Leu Trp Val Ser Val Val Ala Ala Leu Ala Leu Ala Val 
1               5                   10                  15      


Leu Ala Pro Gly Ala Gly Glu Gln Arg Arg Arg Ala Ala Lys Ala Pro 
            20                  25                  30          


Asn Val Val Leu Val Val Ser Asp Ser Phe Asp Gly Arg Leu Thr Phe 
        35                  40                  45              


His Pro Gly Ser Gln Val Val Lys Leu Pro Phe Ile Asn Phe Met Lys 
    50                  55                  60                  


Thr Arg Gly Thr Ser Phe Leu Asn Ala Tyr Thr Asn Ser Pro Ile Cys 
65                  70                  75                  80  


Cys Pro Ser Arg Ala Ala Met Trp Ser Gly Leu Phe Thr His Leu Thr 
                85                  90                  95      


Glu Ser Trp Asn Asn Phe Lys Gly Leu Asp Pro Asn Tyr Thr Thr Trp 
            100                 105                 110         


Met Asp Val Met Glu Arg His Gly Tyr Arg Thr Gln Lys Phe Gly Lys 
        115                 120                 125             


Leu Asp Tyr Thr Ser Gly His His Ser Ile Arg His Ser Glu Arg Gly 
    130                 135                 140                 


Ser Thr Asn Gln Arg Ser Glu Lys Val 
145                 150             


<210>  1113
<211>  536
<212>  PRT
<213>  Homo Sapiens

<400>  1113

Met Leu Leu Leu Trp Val Ser Val Val Ala Ala Leu Ala Leu Ala Val 
1               5                   10                  15      


Leu Ala Pro Gly Ala Gly Glu Gln Arg Arg Arg Ala Ala Lys Ala Pro 
            20                  25                  30          


Asn Val Val Leu Val Val Ser Asp Ser Phe Asp Gly Arg Leu Thr Phe 
        35                  40                  45              


His Pro Gly Ser Gln Val Val Lys Leu Pro Phe Ile Asn Phe Met Lys 
    50                  55                  60                  


Thr Arg Gly Thr Ser Phe Leu Asn Ala Tyr Thr Asn Ser Pro Ile Cys 
65                  70                  75                  80  


Cys Pro Ser Arg Ala Ala Met Trp Ser Gly Leu Phe Thr His Leu Thr 
                85                  90                  95      


Glu Ser Trp Asn Asn Phe Lys Gly Leu Asp Pro Asn Tyr Thr Thr Trp 
            100                 105                 110         


Met Asp Val Met Glu Arg His Gly Tyr Arg Thr Gln Lys Phe Gly Lys 
        115                 120                 125             


Leu Asp Tyr Thr Ser Gly His His Ser Ile Ser Asn Arg Val Glu Ala 
    130                 135                 140                 


Trp Thr Arg Asp Val Ala Phe Leu Leu Arg Gln Glu Gly Arg Pro Met 
145                 150                 155                 160 


Val Asn Leu Ile Arg Asn Arg Thr Lys Val Arg Val Met Glu Arg Asp 
                165                 170                 175     


Trp Gln Asn Thr Asp Lys Ala Val Asn Trp Leu Arg Lys Glu Ala Ile 
            180                 185                 190         


Asn Tyr Thr Glu Pro Phe Val Ile Tyr Leu Gly Leu Asn Leu Pro His 
        195                 200                 205             


Pro Tyr Pro Ser Pro Ser Ser Gly Glu Asn Phe Gly Ser Ser Thr Phe 
    210                 215                 220                 


His Thr Ser Leu Tyr Trp Leu Glu Lys Val Ser His Asp Ala Ile Lys 
225                 230                 235                 240 


Ile Pro Lys Trp Ser Pro Leu Ser Glu Met His Pro Val Asp Tyr Tyr 
                245                 250                 255     


Ser Ser Tyr Thr Lys Asn Cys Thr Gly Arg Phe Thr Lys Lys Glu Ile 
            260                 265                 270         


Lys Asn Ile Arg Ala Phe Tyr Tyr Ala Met Cys Ala Glu Thr Asp Ala 
        275                 280                 285             


Met Leu Gly Glu Ile Ile Leu Ala Leu His Gln Leu Asp Leu Leu Gln 
    290                 295                 300                 


Lys Thr Ile Val Ile Tyr Ser Ser Asp His Gly Glu Leu Ala Met Glu 
305                 310                 315                 320 


His Arg Gln Phe Tyr Lys Met Ser Met Tyr Glu Ala Ser Ala His Val 
                325                 330                 335     


Pro Leu Leu Met Met Gly Pro Gly Ile Lys Ala Gly Leu Gln Val Ser 
            340                 345                 350         


Asn Val Val Ser Leu Val Asp Ile Tyr Pro Thr Met Leu Asp Ile Ala 
        355                 360                 365             


Gly Ile Pro Leu Pro Gln Asn Leu Ser Gly Tyr Ser Leu Leu Pro Leu 
    370                 375                 380                 


Ser Ser Glu Thr Phe Lys Asn Glu His Lys Val Lys Asn Leu His Pro 
385                 390                 395                 400 


Pro Trp Ile Leu Ser Glu Phe His Gly Cys Asn Val Asn Ala Ser Thr 
                405                 410                 415     


Tyr Met Leu Arg Thr Asn His Trp Lys Tyr Ile Ala Tyr Ser Asp Gly 
            420                 425                 430         


Ala Ser Ile Leu Pro Gln Leu Phe Asp Leu Ser Ser Asp Pro Asp Glu 
        435                 440                 445             


Leu Thr Asn Val Ala Val Lys Phe Pro Glu Ile Thr Tyr Ser Leu Asp 
    450                 455                 460                 


Gln Lys Leu His Ser Ile Ile Asn Tyr Pro Lys Val Ser Ala Ser Val 
465                 470                 475                 480 


His Gln Tyr Asn Lys Glu Gln Phe Ile Lys Trp Lys Gln Ser Ile Gly 
                485                 490                 495     


Gln Asn Tyr Ser Asn Val Ile Ala Asn Leu Arg Trp His Gln Asp Trp 
            500                 505                 510         


Gln Lys Glu Pro Arg Lys Tyr Glu Asn Ala Ile Asp Gln Trp Leu Lys 
        515                 520                 525             


Thr His Met Asn Pro Arg Ala Val 
    530                 535     


<210>  1114
<211>  395
<212>  PRT
<213>  Homo Sapiens

<400>  1114

Met Leu Leu Leu Trp Val Ser Val Val Ala Ala Leu Ala Leu Ala Val 
1               5                   10                  15      


Leu Ala Pro Gly Ala Gly Glu Gln Arg Arg Arg Ala Ala Lys Ala Pro 
            20                  25                  30          


Asn Val Val Leu Val Val Ser Asp Ser Phe Asp Gly Arg Leu Thr Phe 
        35                  40                  45              


His Pro Gly Ser Gln Val Val Lys Leu Pro Phe Ile Asn Phe Met Lys 
    50                  55                  60                  


Thr Arg Gly Thr Ser Phe Leu Asn Ala Tyr Thr Asn Ser Pro Ile Cys 
65                  70                  75                  80  


Cys Pro Ser Arg Ala Ala Met Trp Ser Gly Leu Phe Thr His Leu Thr 
                85                  90                  95      


Glu Ser Trp Asn Asn Phe Lys Gly Leu Asp Pro Asn Tyr Thr Thr Trp 
            100                 105                 110         


Met Asp Val Met Glu Arg His Gly Tyr Arg Thr Gln Lys Phe Gly Lys 
        115                 120                 125             


Leu Asp Tyr Thr Ser Gly His His Ser Ile Ser Asn Arg Val Glu Ala 
    130                 135                 140                 


Trp Thr Arg Asp Val Ala Phe Leu Leu Arg Gln Glu Gly Arg Pro Met 
145                 150                 155                 160 


Val Asn Leu Ile Arg Asn Arg Thr Lys Val Arg Val Met Glu Arg Asp 
                165                 170                 175     


Trp Gln Asn Thr Asp Lys Ala Val Asn Trp Leu Arg Lys Glu Ala Ile 
            180                 185                 190         


Asn Tyr Thr Glu Pro Phe Val Ile Tyr Leu Gly Leu Asn Leu Pro His 
        195                 200                 205             


Pro Tyr Pro Ser Pro Ser Ser Gly Glu Asn Phe Gly Ser Ser Thr Phe 
    210                 215                 220                 


His Thr Ser Leu Tyr Trp Leu Glu Lys Val Ser His Asp Ala Ile Lys 
225                 230                 235                 240 


Ile Pro Lys Trp Ser Pro Leu Ser Glu Met His Pro Val Asp Tyr Tyr 
                245                 250                 255     


Ser Ser Tyr Thr Lys Asn Cys Thr Gly Arg Phe Thr Lys Lys Glu Ile 
            260                 265                 270         


Lys Asn Ile Arg Ala Phe Tyr Tyr Ala Met Cys Ala Glu Thr Asp Ala 
        275                 280                 285             


Met Leu Gly Glu Ile Ile Leu Ala Leu His Gln Leu Asp Leu Leu Gln 
    290                 295                 300                 


Lys Thr Ile Val Ile Tyr Ser Ser Asp His Gly Glu Leu Ala Met Glu 
305                 310                 315                 320 


His Arg Gln Phe Tyr Lys Met Ser Met Tyr Glu Ala Ser Ala His Val 
                325                 330                 335     


Pro Leu Leu Met Met Gly Pro Gly Ile Lys Ala Gly Leu Gln Val Ser 
            340                 345                 350         


Asn Val Val Ser Leu Val Asp Ile Tyr Pro Thr Met Leu Asp Glu Lys 
        355                 360                 365             


Thr Glu Val Glu Ile Ser Lys Leu Leu Ala Glu Val His Met Ala Ser 
    370                 375                 380                 


Gly Ile Leu Leu Glu Phe Leu Cys Leu Arg Thr 
385                 390                 395 


<210>  1115
<211>  46
<212>  PRT
<213>  Homo Sapiens

<400>  1115

Met Leu Leu Leu Trp Val Ser Val Val Ala Ala Leu Ala Leu Ala Val 
1               5                   10                  15      


Leu Ala Pro Gly Ala Gly Glu Gln Arg Arg Arg Ala Ala Lys Ala Pro 
            20                  25                  30          


Asn Val Val Leu Val Val Ser Asp Ser Phe Ile Pro Asp Asp 
        35                  40                  45      


<210>  1116
<211>  92
<212>  PRT
<213>  Homo Sapiens

<400>  1116

Arg Ala Ala Lys Ala Pro Asn Val Val Leu Val Val Ser Asp Ser Phe 
1               5                   10                  15      


Asp Gly Arg Leu Thr Phe His Pro Gly Ser Gln Val Val Lys Leu Pro 
            20                  25                  30          


Phe Ile Asn Phe Met Lys Thr Arg Gly Thr Ser Phe Leu Asn Ala Tyr 
        35                  40                  45              


Thr Asn Ser Pro Ile Cys Cys Pro Ser Arg Ala Val Ile Val Trp Lys 
    50                  55                  60                  


Arg Gly Gln Glu Met Leu Leu Ser Tyr Ser Asp Lys Lys Ala Gly Pro 
65                  70                  75                  80  


Trp Leu Ile Leu Ser Val Thr Gly Leu Lys Ser Glu 
                85                  90          


<210>  1117
<211>  117
<212>  PRT
<213>  Homo Sapiens

<400>  1117

Lys Thr Cys Ser His Tyr Glu Cys Ala Phe Leu Gly Gly Leu Lys Thr 
1               5                   10                  15      


Glu Asn Cys Ile Glu Asn Leu Glu Tyr Phe Gln Pro Ile Tyr Val Tyr 
            20                  25                  30          


Asn Pro Gly Glu Lys Asn Gln Lys Leu Glu Asp His Ser Glu Lys Asn 
        35                  40                  45              


Trp Lys Leu Glu Asp His Gly Glu Lys Asn Gln Lys Leu Glu Asp His 
    50                  55                  60                  


Gly Val Lys Ile Leu Glu Pro Thr Gln Ile Pro Gly Met Lys Ile Pro 
65                  70                  75                  80  


Glu Pro Phe Pro Leu Pro Gly Ile Lys Met Ile Gln Leu Asn Glu Lys 
                85                  90                  95      


Pro Glu Asp Lys Ser Gln Gly Asn Ile Asn Asn Pro Thr Pro Gly Pro 
            100                 105                 110         


Val Pro Val Pro Gly 
        115         


<210>  1118
<211>  107
<212>  PRT
<213>  Homo Sapiens

<400>  1118

Met Lys Thr Gly His Phe Glu Ile Val Thr Met Leu Leu Ala Thr Met 
1               5                   10                  15      


Ile Leu Val Asp Ile Phe Gln Val Lys Ala Glu Val Leu Asp Met Ala 
            20                  25                  30          


Asp Asn Ala Phe Asp Asp Glu Tyr Leu Lys Cys Thr Asp Arg Met Glu 
        35                  40                  45              


Ile Lys Tyr Val Pro Gln Leu Leu Lys Glu Glu Lys Ala Ser His Gln 
    50                  55                  60                  


Gln Leu Asp Thr Val Trp Glu Asn Ala Lys Ala Lys Trp Ala Ala Arg 
65                  70                  75                  80  


Lys Thr Gln Ile Phe Leu Pro Met Asn Phe Lys Asp Asn His Gly Ile 
                85                  90                  95      


Ala Leu Met Ala Tyr Ile Ser Glu Ala Gln Glu 
            100                 105         


<210>  1119
<211>  129
<212>  PRT
<213>  Homo Sapiens

<400>  1119

Met Lys Thr Gly His Phe Glu Ile Val Thr Met Leu Leu Ala Thr Met 
1               5                   10                  15      


Ile Leu Val Asp Ile Phe Gln Val Lys Ala Glu Val Leu Asp Met Ala 
            20                  25                  30          


Asp Asn Ala Phe Asp Asp Glu Tyr Leu Lys Cys Thr Asp Arg Met Glu 
        35                  40                  45              


Ile Lys Tyr Val Pro Gln Leu Leu Lys Glu Glu Lys Ala Ser His Gln 
    50                  55                  60                  


Gln Leu Asp Thr Val Trp Glu Asn Ala Lys Ala Lys Trp Ala Ala Arg 
65                  70                  75                  80  


Lys Thr Gln Ile Phe Leu Pro Met Asn Phe Lys Asp Asn His Gly Ile 
                85                  90                  95      


Ala Leu Met Ala Tyr Ile Ser Glu Ala Gln Glu Gln Thr Pro Phe Tyr 
            100                 105                 110         


His Leu Phe Ser Glu Ala Val Lys Met Ala Gly Gln Ser Arg Glu Asp 
        115                 120                 125             


Tyr 
    


<210>  1120
<211>  175
<212>  PRT
<213>  Homo Sapiens

<400>  1120

Met Lys Thr Gly His Phe Glu Ile Val Thr Met Leu Leu Ala Thr Met 
1               5                   10                  15      


Ile Leu Val Asp Ile Phe Gln Val Lys Ala Glu Val Leu Asp Met Ala 
            20                  25                  30          


Asp Asn Ala Phe Asp Asp Glu Tyr Leu Lys Cys Thr Asp Arg Met Glu 
        35                  40                  45              


Ile Lys Tyr Val Pro Gln Leu Leu Lys Glu Glu Lys Ala Ser His Gln 
    50                  55                  60                  


Gln Leu Asp Thr Val Trp Glu Asn Ala Lys Ala Lys Trp Ala Ala Arg 
65                  70                  75                  80  


Lys Thr Gln Ile Phe Leu Pro Met Asn Phe Lys Asp Asn His Gly Ile 
                85                  90                  95      


Ala Leu Met Ala Tyr Ile Ser Glu Ala Gln Glu Gln Thr Pro Phe Tyr 
            100                 105                 110         


His Leu Phe Ser Glu Ala Val Lys Met Ala Gly Gln Ser Arg Glu Asp 
        115                 120                 125             


Tyr Ile Tyr Gly Phe Gln Phe Lys Ala Phe His Phe Tyr Leu Thr Arg 
    130                 135                 140                 


Ala Leu Gln Leu Leu Arg Lys Pro Cys Glu Ala Ser Ser Lys Thr Val 
145                 150                 155                 160 


Val Tyr Arg Thr Ser Gln Gly Thr Ser Phe Thr Phe Gly Gly Leu 
                165                 170                 175 


<210>  1121
<211>  202
<212>  PRT
<213>  Homo Sapiens

<400>  1121

Met Lys Thr Gly His Phe Glu Ile Val Thr Met Leu Leu Ala Thr Met 
1               5                   10                  15      


Ile Leu Val Asp Ile Phe Gln Val Lys Ala Glu Val Leu Asp Met Ala 
            20                  25                  30          


Asp Asn Ala Phe Asp Asp Glu Tyr Leu Lys Cys Thr Asp Arg Met Glu 
        35                  40                  45              


Ile Lys Tyr Val Pro Gln Leu Leu Lys Glu Glu Lys Ala Ser His Gln 
    50                  55                  60                  


Gln Leu Asp Thr Val Trp Glu Asn Ala Lys Ala Lys Trp Ala Ala Arg 
65                  70                  75                  80  


Lys Thr Gln Ile Phe Leu Pro Met Asn Phe Lys Asp Asn His Gly Ile 
                85                  90                  95      


Ala Leu Met Ala Tyr Ile Ser Glu Ala Gln Glu Gln Thr Pro Phe Tyr 
            100                 105                 110         


His Leu Phe Ser Glu Ala Val Lys Met Ala Gly Gln Ser Arg Glu Asp 
        115                 120                 125             


Tyr Ile Tyr Gly Phe Gln Phe Lys Ala Phe His Phe Tyr Leu Thr Arg 
    130                 135                 140                 


Ala Leu Gln Leu Leu Arg Lys Pro Cys Glu Ala Ser Ser Lys Thr Val 
145                 150                 155                 160 


Val Tyr Arg Thr Ser Gln Gly Thr Ser Phe Thr Phe Gly Gly Leu Asn 
                165                 170                 175     


Gln Ala Arg Phe Gly His Phe Thr Leu Ala Tyr Ser Ala Lys Pro Gln 
            180                 185                 190         


Ala Ala Asn Asp Gln Leu Thr Val Leu Ser 
        195                 200         


<210>  1122
<211>  389
<212>  PRT
<213>  Homo Sapiens

<400>  1122

Met Lys Thr Gly His Phe Glu Ile Val Thr Met Leu Leu Ala Thr Met 
1               5                   10                  15      


Ile Leu Val Asp Ile Phe Gln Val Lys Ala Glu Val Leu Asp Met Ala 
            20                  25                  30          


Asp Asn Ala Phe Asp Asp Glu Tyr Leu Lys Cys Thr Asp Arg Met Glu 
        35                  40                  45              


Ile Lys Tyr Val Pro Gln Leu Leu Lys Glu Glu Lys Ala Ser His Gln 
    50                  55                  60                  


Gln Leu Asp Thr Val Trp Glu Asn Ala Lys Ala Lys Trp Ala Ala Arg 
65                  70                  75                  80  


Lys Thr Gln Ile Phe Leu Pro Met Asn Phe Lys Asp Asn His Gly Ile 
                85                  90                  95      


Ala Leu Met Ala Tyr Ile Ser Glu Ala Gln Glu Gln Thr Pro Phe Tyr 
            100                 105                 110         


His Leu Phe Ser Glu Ala Val Lys Met Ala Gly Gln Ser Arg Glu Asp 
        115                 120                 125             


Tyr Ile Tyr Gly Phe Gln Phe Lys Ala Phe His Phe Tyr Leu Thr Arg 
    130                 135                 140                 


Ala Leu Gln Leu Leu Arg Lys Pro Cys Glu Ala Ser Ser Lys Thr Val 
145                 150                 155                 160 


Val Tyr Arg Thr Ser Gln Gly Thr Ser Phe Thr Phe Gly Gly Leu Asn 
                165                 170                 175     


Gln Ala Arg Phe Gly His Phe Thr Leu Ala Tyr Ser Ala Lys Pro Gln 
            180                 185                 190         


Ala Ala Asn Asp Gln Leu Thr Val Leu Ser Ile Tyr Thr Cys Leu Gly 
        195                 200                 205             


Val Asp Ile Glu Asn Phe Leu Asp Lys Glu Ser Glu Arg Ile Thr Leu 
    210                 215                 220                 


Ile Pro Leu Asn Glu Val Phe Gln Val Ser Gln Glu Gly Ala Gly Asn 
225                 230                 235                 240 


Asn Leu Ile Leu Gln Ser Ile Asn Lys Thr Cys Ser His Tyr Glu Cys 
                245                 250                 255     


Ala Phe Leu Gly Gly Leu Lys Thr Glu Asn Cys Ile Glu Asn Leu Glu 
            260                 265                 270         


Tyr Phe Gln Pro Ile Tyr Val Tyr Asn Pro Gly Glu Lys Asn Gln Lys 
        275                 280                 285             


Leu Glu Asp His Ser Glu Lys Asn Trp Lys Leu Glu Asp His Gly Glu 
    290                 295                 300                 


Lys Asn Gln Lys Leu Glu Asp His Gly Val Lys Ile Leu Glu Pro Thr 
305                 310                 315                 320 


Gln Ile Pro Gly Met Lys Ile Pro Glu Pro Phe Pro Leu Pro Glu Asp 
                325                 330                 335     


Lys Ser Gln Gly Asn Ile Asn Asn Pro Thr Pro Gly Pro Val Pro Val 
            340                 345                 350         


Pro Gly Pro Lys Ser His Pro Ser Ala Ser Ser Gly Lys Leu Leu Leu 
        355                 360                 365             


Pro Gln Phe Gly Met Val Ile Ile Leu Ile Ser Val Ser Ala Ile Asn 
    370                 375                 380                 


Leu Phe Val Ala Leu 
385                 


<210>  1123
<211>  378
<212>  PRT
<213>  Homo Sapiens

<400>  1123

Met Lys Thr Gly His Phe Glu Ile Val Thr Met Leu Leu Ala Thr Met 
1               5                   10                  15      


Ile Leu Val Asp Ile Phe Gln Val Lys Ala Glu Val Leu Asp Met Ala 
            20                  25                  30          


Asp Asn Ala Phe Asp Asp Glu Tyr Leu Lys Cys Thr Asp Arg Met Glu 
        35                  40                  45              


Ile Lys Tyr Val Pro Gln Leu Leu Lys Glu Glu Lys Ala Ser His Gln 
    50                  55                  60                  


Gln Leu Asp Thr Val Trp Glu Asn Ala Lys Ala Lys Trp Ala Ala Arg 
65                  70                  75                  80  


Lys Thr Gln Ile Phe Leu Pro Met Asn Phe Lys Asp Asn His Gly Ile 
                85                  90                  95      


Ala Leu Met Ala Tyr Ile Ser Glu Ala Gln Glu Gln Thr Pro Phe Tyr 
            100                 105                 110         


His Leu Phe Ser Glu Ala Val Lys Met Ala Gly Gln Ser Arg Glu Asp 
        115                 120                 125             


Tyr Ile Tyr Gly Phe Gln Phe Lys Ala Phe His Phe Tyr Leu Thr Arg 
    130                 135                 140                 


Ala Leu Gln Leu Leu Arg Lys Pro Cys Glu Ala Ser Ser Lys Thr Val 
145                 150                 155                 160 


Val Tyr Arg Thr Ser Gln Gly Thr Ser Phe Thr Phe Gly Gly Leu Asn 
                165                 170                 175     


Gln Ala Arg Phe Gly His Phe Thr Leu Ala Tyr Ser Ala Lys Pro Gln 
            180                 185                 190         


Ala Ala Asn Asp Gln Leu Thr Val Leu Ser Ile Tyr Thr Cys Leu Gly 
        195                 200                 205             


Val Asp Ile Glu Asn Phe Leu Asp Lys Glu Ser Glu Arg Ile Thr Leu 
    210                 215                 220                 


Ile Pro Leu Asn Glu Val Phe Gln Val Ser Gln Glu Gly Ala Gly Asn 
225                 230                 235                 240 


Asn Leu Ile Leu Gln Ser Ile Asn Lys Thr Cys Ser His Tyr Glu Cys 
                245                 250                 255     


Ala Phe Leu Gly Gly Leu Lys Thr Glu Asn Cys Ile Glu Asn Leu Glu 
            260                 265                 270         


Tyr Phe Gln Pro Ile Tyr Val Tyr Asn Pro Gly Glu Lys Asn Gln Lys 
        275                 280                 285             


Leu Glu Asp His Ser Glu Lys Asn Trp Lys Leu Glu Asp His Gly Glu 
    290                 295                 300                 


Lys Asn Gln Lys Leu Glu Asp His Gly Val Lys Ile Leu Glu Pro Thr 
305                 310                 315                 320 


Gln Ile Pro Glu Asp Lys Ser Gln Gly Asn Ile Asn Asn Pro Thr Pro 
                325                 330                 335     


Gly Pro Val Pro Val Pro Gly Pro Lys Ser His Pro Ser Ala Ser Ser 
            340                 345                 350         


Gly Lys Leu Leu Leu Pro Gln Phe Gly Met Val Ile Ile Leu Ile Ser 
        355                 360                 365             


Val Ser Ala Ile Asn Leu Phe Val Ala Leu 
    370                 375             


<210>  1124
<211>  367
<212>  PRT
<213>  Homo Sapiens

<400>  1124

Met Lys Thr Gly His Phe Glu Ile Val Thr Met Leu Leu Ala Thr Met 
1               5                   10                  15      


Ile Leu Val Asp Ile Phe Gln Val Lys Ala Glu Val Leu Asp Met Ala 
            20                  25                  30          


Asp Asn Ala Phe Asp Asp Glu Tyr Leu Lys Cys Thr Asp Arg Met Glu 
        35                  40                  45              


Ile Lys Tyr Val Pro Gln Leu Leu Lys Glu Glu Lys Ala Ser His Gln 
    50                  55                  60                  


Gln Leu Asp Thr Val Trp Glu Asn Ala Lys Ala Lys Trp Ala Ala Arg 
65                  70                  75                  80  


Lys Thr Gln Ile Phe Leu Pro Met Asn Phe Lys Asp Asn His Gly Ile 
                85                  90                  95      


Ala Leu Met Ala Tyr Ile Ser Glu Ala Gln Glu Gln Thr Pro Phe Tyr 
            100                 105                 110         


His Leu Phe Ser Glu Ala Val Lys Met Ala Gly Gln Ser Arg Glu Asp 
        115                 120                 125             


Tyr Ile Tyr Gly Phe Gln Phe Lys Ala Phe His Phe Tyr Leu Thr Arg 
    130                 135                 140                 


Ala Leu Gln Leu Leu Arg Lys Pro Cys Glu Ala Ser Ser Lys Thr Val 
145                 150                 155                 160 


Val Tyr Arg Thr Ser Gln Gly Thr Ser Phe Thr Phe Gly Gly Leu Asn 
                165                 170                 175     


Gln Ala Arg Phe Gly His Phe Thr Leu Ala Tyr Ser Ala Lys Pro Gln 
            180                 185                 190         


Ala Ala Asn Asp Gln Leu Thr Val Leu Ser Ile Tyr Thr Cys Leu Gly 
        195                 200                 205             


Val Asp Ile Glu Asn Phe Leu Asp Lys Glu Ser Glu Arg Ile Thr Leu 
    210                 215                 220                 


Ile Pro Leu Asn Glu Val Phe Gln Val Ser Gln Glu Gly Ala Gly Asn 
225                 230                 235                 240 


Asn Leu Ile Leu Gln Ser Ile Asn Lys Thr Cys Ser His Tyr Glu Cys 
                245                 250                 255     


Ala Phe Leu Gly Gly Leu Lys Thr Glu Asn Cys Ile Glu Asn Leu Glu 
            260                 265                 270         


Tyr Phe Gln Pro Ile Tyr Val Tyr Asn Pro Gly Glu Lys Asn Gln Lys 
        275                 280                 285             


Leu Glu Asp His Ser Glu Lys Asn Trp Lys Leu Glu Asp His Gly Glu 
    290                 295                 300                 


Lys Asn Gln Lys Leu Glu Asp His Gly Val Lys Ile Leu Glu Pro Thr 
305                 310                 315                 320 


Gln Ile Pro Ala Pro Gly Pro Val Pro Val Pro Gly Pro Lys Ser His 
                325                 330                 335     


Pro Ser Ala Ser Ser Gly Lys Leu Leu Leu Pro Gln Phe Gly Met Val 
            340                 345                 350         


Ile Ile Leu Ile Ser Val Ser Ala Ile Asn Leu Phe Val Ala Leu 
        355                 360                 365         


<210>  1125
<211>  314
<212>  PRT
<213>  Homo Sapiens

<400>  1125

Met Gly Pro Leu Ile Asn Arg Cys Lys Lys Ile Leu Leu Pro Thr Thr 
1               5                   10                  15      


Val Pro Pro Ala Thr Met Arg Ile Trp Leu Leu Gly Gly Leu Leu Pro 
            20                  25                  30          


Phe Leu Leu Leu Leu Ser Gly Leu Gln Arg Pro Thr Glu Gly Ser Glu 
        35                  40                  45              


Val Ala Ile Lys Ile Asp Phe Asp Phe Ala Pro Gly Ser Phe Asp Asp 
    50                  55                  60                  


Gln Tyr Gln Gly Cys Ser Lys Gln Val Met Glu Lys Leu Thr Gln Gly 
65                  70                  75                  80  


Asp Tyr Phe Thr Lys Asp Ile Glu Ala Gln Lys Asn Tyr Phe Arg Met 
                85                  90                  95      


Trp Gln Lys Ala His Leu Ala Trp Leu Asn Gln Gly Lys Val Leu Pro 
            100                 105                 110         


Gln Asn Met Thr Thr Thr His Ala Val Ala Ile Leu Phe Tyr Thr Leu 
        115                 120                 125             


Asn Ser Asn Val His Ser Asp Phe Thr Arg Ala Met Ala Ser Val Ala 
    130                 135                 140                 


Arg Thr Pro Gln Gln Tyr Glu Arg Ser Phe His Phe Lys Tyr Leu His 
145                 150                 155                 160 


Tyr Tyr Leu Thr Ser Ala Ile Gln Leu Leu Arg Lys Asp Ser Ile Met 
                165                 170                 175     


Glu Asn Gly Thr Leu Cys Tyr Glu Val His Tyr Arg Thr Lys Asp Val 
            180                 185                 190         


His Phe Asn Ala Tyr Thr Gly Ala Thr Ile Arg Phe Gly Gln Phe Leu 
        195                 200                 205             


Ser Thr Ser Leu Leu Lys Glu Glu Ala Gln Glu Phe Gly Asn Gln Thr 
    210                 215                 220                 


Leu Phe Thr Ile Phe Thr Cys Leu Gly Ala Pro Val Gln Tyr Phe Ser 
225                 230                 235                 240 


Leu Lys Lys Glu Val Leu Ile Pro Pro Tyr Glu Leu Phe Lys Val Ile 
                245                 250                 255     


Asn Met Ser Tyr His Pro Arg Gly Asp Trp Leu Gln Leu Arg Ser Thr 
            260                 265                 270         


Gly Asn Leu Ser Thr Tyr Asn Cys Gln Leu Leu Lys Ala Ser Ser Lys 
        275                 280                 285             


Lys Cys Ile Pro Asp Pro Ile Ala Ile Ala Ser Leu Ser Phe Leu Thr 
    290                 295                 300                 


Ser Val Ile Ile Phe Ser Lys Ser Arg Val 
305                 310                 


<210>  1126
<211>  41
<212>  PRT
<213>  Homo Sapiens

<400>  1126

Pro Pro Ala Thr Met Arg Ile Trp Leu Leu Gly Gly Leu Leu Pro Phe 
1               5                   10                  15      


Leu Leu Leu Leu Ser Gly Leu Gln Arg Pro Thr Glu Gly Ser Glu Leu 
            20                  25                  30          


Pro Ala Arg Asn Ala Ser Leu Ile Leu 
        35                  40      


<210>  1127
<211>  65
<212>  PRT
<213>  Homo Sapiens

<400>  1127

Pro Pro Ala Thr Met Arg Ile Trp Leu Leu Gly Gly Leu Leu Pro Phe 
1               5                   10                  15      


Leu Leu Leu Leu Ser Gly Leu Gln Arg Pro Thr Glu Gly Ser Glu Val 
            20                  25                  30          


Ala Ile Lys Ile Asp Phe Asp Phe Ala Pro Gly Ser Phe Asp Asp Gln 
        35                  40                  45              


Tyr Gln Gly Cys Ser Lys Gln Leu Pro Ala Arg Asn Ala Ser Leu Ile 
    50                  55                  60                  


Leu 
65  


<210>  1128
<211>  273
<212>  PRT
<213>  Homo Sapiens

<400>  1128

Pro Pro Ala Thr Met Arg Ile Trp Leu Leu Gly Gly Leu Leu Pro Phe 
1               5                   10                  15      


Leu Leu Leu Leu Ser Gly Leu Gln Arg Pro Thr Glu Gly Ser Glu Val 
            20                  25                  30          


Ala Ile Lys Ile Asp Phe Asp Phe Ala Pro Gly Ser Phe Asp Asp Gln 
        35                  40                  45              


Tyr Gln Gly Cys Ser Lys Gln Val Met Glu Lys Leu Thr Gln Gly Asp 
    50                  55                  60                  


Tyr Phe Thr Lys Asp Ile Glu Ala Gln Lys Asn Tyr Phe Arg Met Trp 
65                  70                  75                  80  


Gln Lys Ala His Leu Ala Trp Leu Asn Gln Gly Lys Val Leu Pro Gln 
                85                  90                  95      


Asn Met Thr Thr Thr His Ala Val Ala Ile Leu Phe Tyr Thr Leu Asn 
            100                 105                 110         


Ser Asn Val His Ser Asp Phe Thr Arg Ala Met Ala Ser Val Ala Arg 
        115                 120                 125             


Thr Pro Gln Gln Tyr Glu Arg Ser Phe His Phe Lys Tyr Leu His Tyr 
    130                 135                 140                 


Tyr Leu Thr Ser Ala Ile Gln Leu Leu Arg Lys Asp Ser Ile Met Glu 
145                 150                 155                 160 


Asn Gly Thr Leu Cys Tyr Glu Val His Tyr Arg Thr Lys Asp Val His 
                165                 170                 175     


Phe Asn Ala Tyr Thr Gly Ala Thr Ile Arg Phe Gly Gln Phe Leu Ser 
            180                 185                 190         


Thr Ser Leu Leu Lys Glu Glu Ala Gln Glu Phe Gly Asn Gln Thr Leu 
        195                 200                 205             


Phe Thr Ile Phe Thr Cys Leu Gly Ala Pro Val Gln Tyr Phe Ser Leu 
    210                 215                 220                 


Lys Lys Glu Val Leu Ile Pro Pro Tyr Glu Leu Phe Lys Val Ile Asn 
225                 230                 235                 240 


Met Ser Tyr His Pro Arg Gly Asp Trp Leu Gln Leu Arg Ser Thr Gly 
                245                 250                 255     


Asn Leu Ser Thr Tyr Asn Cys Gln Leu Leu Lys Gly Ile Leu Tyr Leu 
            260                 265                 270         


Asn 
    


<210>  1129
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  1129

Ala Val Pro Ile Leu Pro Leu Gly Leu Ala Pro Asp Thr Phe Asp Asp 
1               5                   10                  15      


Thr Tyr Val Gly Cys Ala Glu Glu Met Glu Glu Lys Ala Ala Pro Leu 
            20                  25                  30          


Leu Lys Glu Glu Met Ala His His Ala Leu Leu Arg Glu Ser Trp Glu 
        35                  40                  45              


Ala Ala Gln Glu Thr Trp Glu Asp Lys Arg Arg Gly Leu Thr Leu Pro 
    50                  55                  60                  


Pro Gly Phe Lys Ala Gln Asn Gly Ile Ala Ile Met Val Tyr Thr Asn 
65                  70                  75                  80  


Ser Ser Asn Thr Leu Tyr Trp Glu Leu Asn Gln Ala Ala Phe Ser Val 
                85                  90                  95      


Phe Pro Lys Glu Arg Glu Val Leu Ile Pro Pro His Glu Val Phe Leu 
            100                 105                 110         


Val Thr Arg Phe Ser Gln Asp Gly Ala Gln Ser Leu Val Thr Leu Trp 
        115                 120                 125             


Ser Tyr Asn Gln Thr Cys Ser His Phe Asn Cys Ala Tyr Leu Gly Gly 
    130                 135                 140                 


Glu Lys Arg Arg Gly Cys Val Ser 
145                 150         


<210>  1130
<211>  239
<212>  PRT
<213>  Homo Sapiens

<400>  1130

Met Ala Leu Ala Ala Leu Met Ile Ala Leu Gly Ser Leu Gly Leu His 
1               5                   10                  15      


Thr Trp Gln Ala Gln Ala Val Pro Ile Leu Pro Leu Gly Leu Ala Pro 
            20                  25                  30          


Asp Thr Phe Asp Asp Thr Tyr Val Gly Cys Ala Glu Glu Met Glu Glu 
        35                  40                  45              


Lys Ala Ala Pro Leu Leu Lys Glu Glu Met Ala His His Ala Leu Leu 
    50                  55                  60                  


Arg Glu Ser Trp Glu Ala Ala Gln Glu Thr Trp Glu Asp Lys Arg Arg 
65                  70                  75                  80  


Gly Leu Thr Leu Pro Pro Gly Phe Lys Ala Gln Asn Gly Ile Ala Ile 
                85                  90                  95      


Met Val Tyr Thr Asn Ser Ser Asn Thr Leu Tyr Trp Glu Leu Asn Gln 
            100                 105                 110         


Ala Val Arg Thr Gly Gly Gly Ser Arg Glu Leu Tyr Met Arg His Phe 
        115                 120                 125             


Pro Phe Lys Ala Leu His Phe Tyr Leu Ile Arg Ala Leu Gln Leu Leu 
    130                 135                 140                 


Arg Gly Ser Gly Gly Cys Ser Arg Gly Pro Gly Glu Val Val Phe Arg 
145                 150                 155                 160 


Gly Val Gly Ser Leu Arg Phe Glu Pro Lys Arg Leu Gly Asp Ser Val 
                165                 170                 175     


Arg Leu Gly Gln Phe Ala Ser Ser Ser Leu Asp Lys Ala Val Ala His 
            180                 185                 190         


Arg Phe Gly Glu Lys Arg Arg Gly Cys Val Ser Ala Pro Gly Val Gln 
        195                 200                 205             


Leu Gly Ser Gln Ser Glu Gly Ala Ser Ser Leu Pro Pro Trp Lys Thr 
    210                 215                 220                 


Leu Leu Leu Ala Pro Gly Glu Phe Gln Leu Ser Gly Val Gly Pro 
225                 230                 235                 


<210>  1131
<211>  291
<212>  PRT
<213>  Homo Sapiens

<400>  1131

Met Ala Leu Ala Ala Leu Met Ile Ala Leu Gly Ser Leu Gly Leu His 
1               5                   10                  15      


Thr Trp Gln Ala Gln Ala Val Pro Ile Leu Pro Leu Gly Leu Ala Pro 
            20                  25                  30          


Asp Thr Phe Asp Asp Thr Tyr Val Gly Cys Ala Glu Glu Met Glu Glu 
        35                  40                  45              


Lys Ala Ala Pro Leu Leu Lys Glu Glu Met Ala His His Ala Leu Leu 
    50                  55                  60                  


Arg Glu Ser Trp Glu Ala Ala Gln Glu Thr Trp Glu Asp Lys Arg Arg 
65                  70                  75                  80  


Gly Leu Thr Leu Pro Pro Gly Phe Lys Ala Gln Asn Gly Ile Ala Ile 
                85                  90                  95      


Met Val Tyr Thr Asn Ser Ser Asn Thr Leu Tyr Trp Glu Leu Asn Gln 
            100                 105                 110         


Ala Val Arg Thr Gly Gly Gly Ser Arg Glu Leu Tyr Met Arg His Phe 
        115                 120                 125             


Pro Phe Lys Ala Leu His Phe Tyr Leu Ile Arg Ala Leu Gln Leu Leu 
    130                 135                 140                 


Arg Gly Ser Gly Gly Cys Ser Arg Gly Pro Gly Glu Val Val Phe Arg 
145                 150                 155                 160 


Gly Val Gly Ser Leu Arg Phe Glu Pro Lys Arg Leu Gly Asp Ser Val 
                165                 170                 175     


Arg Leu Gly Gln Phe Ala Ser Ser Ser Leu Asp Lys Ala Val Ala His 
            180                 185                 190         


Arg Phe Gly Asn Ala Thr Leu Phe Ser Leu Thr Thr Cys Phe Gly Ala 
        195                 200                 205             


Pro Ile Gln Ala Phe Ser Val Phe Pro Lys Glu Arg Glu Val Leu Ile 
    210                 215                 220                 


Pro Pro His Glu Val Phe Leu Val Thr Arg Phe Ser Gln Asp Gly Ala 
225                 230                 235                 240 


Gln Ser Leu Val Thr Leu Trp Ser Tyr Asn Gln Thr Cys Ser His Phe 
                245                 250                 255     


Asn Cys Ala Tyr Leu Gly Gly Glu Lys Arg Arg Gly Cys Val Ser Ala 
            260                 265                 270         


Pro Gly Ala Leu Gly Thr Gly Asp Leu His Met Thr Lys Arg His Leu 
        275                 280                 285             


Gln Gln Pro 
    290     


<210>  1132
<211>  291
<212>  PRT
<213>  Homo Sapiens

<400>  1132

Met Ala Leu Ala Ala Leu Met Ile Ala Leu Gly Ser Leu Gly Leu His 
1               5                   10                  15      


Thr Trp Gln Ala Gln Ala Val Pro Ile Leu Pro Leu Gly Leu Ala Pro 
            20                  25                  30          


Asp Thr Phe Asp Asp Thr Tyr Val Gly Cys Ala Glu Glu Met Glu Glu 
        35                  40                  45              


Lys Ala Ala Pro Leu Leu Lys Glu Glu Met Ala His His Ala Leu Leu 
    50                  55                  60                  


Arg Glu Ser Trp Glu Ala Ala Gln Glu Thr Trp Glu Asp Lys Arg Arg 
65                  70                  75                  80  


Gly Leu Thr Leu Pro Pro Gly Phe Lys Ala Gln Asn Gly Ile Ala Ile 
                85                  90                  95      


Met Val Tyr Thr Asn Ser Ser Asn Thr Leu Tyr Trp Glu Leu Asn Gln 
            100                 105                 110         


Ala Val Arg Thr Gly Gly Gly Ser Arg Glu Leu Tyr Met Arg His Phe 
        115                 120                 125             


Pro Phe Lys Ala Leu His Phe Tyr Leu Ile Arg Ala Leu Gln Leu Leu 
    130                 135                 140                 


Arg Gly Ser Gly Gly Cys Ser Arg Gly Pro Gly Glu Val Val Phe Arg 
145                 150                 155                 160 


Gly Val Gly Ser Leu Arg Phe Glu Pro Lys Arg Leu Gly Asp Ser Val 
                165                 170                 175     


Arg Leu Gly Gln Phe Ala Ser Ser Ser Leu Asp Lys Ala Val Ala His 
            180                 185                 190         


Arg Phe Gly Asn Ala Thr Leu Phe Ser Leu Thr Thr Cys Phe Gly Ala 
        195                 200                 205             


Pro Ile Gln Ala Phe Ser Val Phe Pro Lys Glu Arg Glu Val Leu Ile 
    210                 215                 220                 


Pro Pro His Glu Val Phe Leu Val Thr Arg Phe Ser Gln Asp Gly Ala 
225                 230                 235                 240 


Gln Ser Leu Val Thr Leu Trp Ser Tyr Asn Gln Thr Cys Ser His Phe 
                245                 250                 255     


Asn Cys Ala Tyr Leu Gly Gly Glu Lys Arg Arg Gly Cys Val Ser Ala 
            260                 265                 270         


Pro Gly Ala Leu Gly Thr Gly Asp Leu His Met Thr Lys Arg His Leu 
        275                 280                 285             


Gln Gln Pro 
    290     


<210>  1133
<211>  264
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1133

Xaa Glu Met Glu Glu Lys Ala Ala Pro Leu Leu Lys Glu Glu Met Ala 
1               5                   10                  15      


His His Ala Leu Leu Arg Glu Ser Trp Glu Ala Ala Gln Glu Thr Trp 
            20                  25                  30          


Glu Asp Lys Arg Arg Gly Leu Thr Leu Pro Pro Gly Phe Lys Ala Gln 
        35                  40                  45              


Asn Gly Ile Ala Ile Met Val Tyr Thr Asn Ser Ser Asn Thr Leu Tyr 
    50                  55                  60                  


Trp Glu Leu Asn Gln Ala Val Arg Thr Gly Gly Gly Ser Arg Glu Leu 
65                  70                  75                  80  


Tyr Met Arg His Phe Pro Phe Lys Ala Leu His Phe Tyr Leu Ile Arg 
                85                  90                  95      


Ala Leu Gln Leu Leu Arg Gly Ser Gly Gly Cys Ser Arg Gly Pro Gly 
            100                 105                 110         


Glu Val Val Phe Arg Gly Val Gly Ser Leu Arg Phe Glu Pro Lys Arg 
        115                 120                 125             


Leu Gly Asp Ser Val Arg Leu Gly Gln Phe Ala Ser Ser Ser Leu Asp 
    130                 135                 140                 


Lys Ala Val Ala His Arg Phe Gly Asn Ala Thr Leu Phe Ser Leu Thr 
145                 150                 155                 160 


Thr Cys Phe Gly Ala Pro Ile Gln Ala Phe Ser Val Phe Pro Lys Glu 
                165                 170                 175     


Arg Glu Val Leu Ile Pro Pro His Glu Val Phe Leu Val Thr Arg Phe 
            180                 185                 190         


Ser Gln Asp Gly Ala Gln Ser Leu Val Thr Leu Trp Ser Tyr Asn Gln 
        195                 200                 205             


Thr Cys Ser His Phe Asn Cys Ala Tyr Leu Gly Gly Glu Lys Arg Arg 
    210                 215                 220                 


Gly Cys Val Ser Ala Pro Gly Val Gln Leu Gly Ser Gln Ser Glu Gly 
225                 230                 235                 240 


Ala Ser Ser Leu Pro Pro Trp Lys Thr Leu Leu Leu Ala Pro Gly Glu 
                245                 250                 255     


Phe Gln Leu Ser Gly Val Gly Pro 
            260                 


<210>  1134
<211>  89
<212>  PRT
<213>  Homo Sapiens

<400>  1134

Met Glu Leu Gly Leu Gly Gly Leu Ser Thr Leu Ser His Cys Pro Trp 
1               5                   10                  15      


Pro Arg Gln Gln Ala Pro Leu Gly Leu Ser Ala Gln Pro Ala Leu Trp 
            20                  25                  30          


Pro Thr Leu Ala Ala Leu Ala Leu Leu Ser Ser Val Ala Glu Ala Ser 
        35                  40                  45              


Leu Gly Ser Ala Pro Arg Ser Pro Ala Pro Arg Glu Gly Pro Pro Pro 
    50                  55                  60                  


Val Leu Ala Ser Pro Ala Gly His Leu Pro Gly Gly Arg Thr Ala Arg 
65                  70                  75                  80  


Trp Cys Ser Gly Arg Ala Arg Arg Pro 
                85                  


<210>  1135
<211>  89
<212>  PRT
<213>  Homo Sapiens

<400>  1135

Met Glu Leu Gly Leu Gly Gly Leu Ser Thr Leu Ser His Cys Pro Trp 
1               5                   10                  15      


Pro Arg Gln Gln Ala Pro Leu Gly Leu Ser Ala Gln Pro Ala Leu Trp 
            20                  25                  30          


Pro Thr Leu Ala Ala Leu Ala Leu Leu Ser Ser Val Ala Glu Ala Ser 
        35                  40                  45              


Leu Gly Ser Ala Pro Arg Ser Pro Ala Pro Arg Glu Gly Pro Pro Pro 
    50                  55                  60                  


Val Leu Ala Ser Pro Ala Gly His Leu Pro Gly Gly Arg Thr Ala Arg 
65                  70                  75                  80  


Trp Cys Ser Gly Arg Ala Arg Arg Pro 
                85                  


<210>  1136
<211>  228
<212>  PRT
<213>  Homo Sapiens

<400>  1136

Met Glu Leu Gly Leu Gly Gly Leu Ser Thr Leu Ser His Cys Pro Trp 
1               5                   10                  15      


Pro Arg Gln Gln Ala Pro Leu Gly Leu Ser Ala Gln Pro Ala Leu Trp 
            20                  25                  30          


Pro Thr Leu Ala Ala Leu Ala Leu Leu Ser Ser Val Ala Glu Ala Ser 
        35                  40                  45              


Leu Gly Ser Ala Pro Arg Ser Pro Ala Pro Arg Glu Gly Pro Pro Pro 
    50                  55                  60                  


Val Leu Ala Ser Pro Ala Gly His Leu Pro Gly Gly Arg Thr Ala Arg 
65                  70                  75                  80  


Trp Cys Ser Gly Arg Ala Arg Arg Pro Pro Pro Gln Pro Ser Arg Pro 
                85                  90                  95      


Ala Pro Pro Pro Pro Ala Pro Pro Ser Ala Leu Pro Arg Gly Gly Arg 
            100                 105                 110         


Ala Ala Arg Ala Gly Gly Pro Gly Ser Arg Ala Arg Ala Ala Gly Ala 
        115                 120                 125             


Arg Gly Cys Arg Leu Arg Ser Gln Leu Val Pro Val Arg Ala Leu Gly 
    130                 135                 140                 


Leu Gly His Arg Ser Asp Glu Leu Val Arg Phe Arg Phe Cys Ser Gly 
145                 150                 155                 160 


Ser Cys Arg Arg Ala Arg Ser Pro His Asp Leu Ser Leu Ala Ser Leu 
                165                 170                 175     


Leu Gly Ala Gly Ala Leu Arg Pro Pro Pro Gly Ser Arg Pro Val Ser 
            180                 185                 190         


Gln Pro Cys Cys Arg Pro Thr Arg Tyr Glu Ala Val Ser Phe Met Asp 
        195                 200                 205             


Val Asn Ser Thr Trp Arg Thr Val Asp Arg Leu Ser Ala Thr Ala Cys 
    210                 215                 220                 


Gly Cys Leu Gly 
225             


<210>  1137
<211>  228
<212>  PRT
<213>  Homo Sapiens

<400>  1137

Met Glu Leu Gly Leu Gly Gly Leu Ser Thr Leu Ser His Cys Pro Trp 
1               5                   10                  15      


Pro Arg Gln Gln Ala Pro Leu Gly Leu Ser Ala Gln Pro Ala Leu Trp 
            20                  25                  30          


Pro Thr Leu Ala Ala Leu Ala Leu Leu Ser Ser Val Ala Glu Ala Ser 
        35                  40                  45              


Leu Gly Ser Ala Pro Arg Ser Pro Ala Pro Arg Glu Gly Pro Pro Pro 
    50                  55                  60                  


Val Leu Ala Ser Pro Ala Gly His Leu Pro Gly Gly Arg Thr Ala Arg 
65                  70                  75                  80  


Trp Cys Ser Gly Arg Ala Arg Arg Pro Pro Pro Gln Pro Ser Arg Pro 
                85                  90                  95      


Ala Pro Pro Pro Pro Ala Pro Pro Ser Ala Leu Pro Arg Gly Gly Arg 
            100                 105                 110         


Ala Ala Arg Ala Gly Gly Pro Gly Ser Arg Ala Arg Ala Ala Gly Ala 
        115                 120                 125             


Arg Gly Cys Arg Leu Arg Ser Gln Leu Val Pro Val Arg Ala Leu Gly 
    130                 135                 140                 


Leu Gly His Arg Ser Asp Glu Leu Val Arg Phe Arg Phe Cys Ser Gly 
145                 150                 155                 160 


Ser Cys Arg Arg Ala Arg Ser Pro His Asp Leu Ser Leu Ala Ser Leu 
                165                 170                 175     


Leu Gly Ala Gly Ala Leu Arg Pro Pro Pro Gly Ser Arg Pro Val Ser 
            180                 185                 190         


Gln Pro Cys Cys Arg Pro Thr Arg Tyr Glu Ala Val Ser Phe Met Asp 
        195                 200                 205             


Val Asn Ser Thr Trp Arg Thr Val Asp Arg Leu Ser Ala Thr Ala Cys 
    210                 215                 220                 


Gly Cys Leu Gly 
225             


<210>  1138
<211>  76
<212>  PRT
<213>  Homo Sapiens

<400>  1138

Met Glu Leu Gly Leu Gly Gly Leu Ser Thr Leu Ser His Cys Pro Trp 
1               5                   10                  15      


Pro Arg Gln Gln Ala Pro Leu Gly Leu Ser Ala Gln Pro Ala Leu Trp 
            20                  25                  30          


Pro Thr Leu Ala Ala Leu Ala Leu Leu Ser Ser Val Ala Glu Ala Ser 
        35                  40                  45              


Leu Gly Ser Ala Pro Arg Ser Pro Ala Pro Arg Glu Gly Pro Pro Pro 
    50                  55                  60                  


Val Leu Ala Ser Pro Ala Gly His Leu Pro Gly Arg 
65                  70                  75      


<210>  1139
<211>  76
<212>  PRT
<213>  Homo Sapiens

<400>  1139

Met Glu Leu Gly Leu Gly Gly Leu Ser Thr Leu Ser His Cys Pro Trp 
1               5                   10                  15      


Pro Arg Gln Gln Ala Pro Leu Gly Leu Ser Ala Gln Pro Ala Leu Trp 
            20                  25                  30          


Pro Thr Leu Ala Ala Leu Ala Leu Leu Ser Ser Val Ala Glu Ala Ser 
        35                  40                  45              


Leu Gly Ser Ala Pro Arg Ser Pro Ala Pro Arg Glu Gly Pro Pro Pro 
    50                  55                  60                  


Val Leu Ala Ser Pro Ala Gly His Leu Pro Gly Arg 
65                  70                  75      


<210>  1140
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  1140

Met Glu Leu Gly Leu Gly Gly Leu Ser Thr Leu Ser His Cys Pro Trp 
1               5                   10                  15      


Pro Arg Gln Gln Pro Ala Leu Trp Pro Thr Leu Ala Ala Leu Ala Leu 
            20                  25                  30          


Leu Ser Ser Val Ala Glu Ala Ser Leu Gly Ser Ala Pro Arg Ser Pro 
        35                  40                  45              


Ala Pro Arg Glu Gly Pro Pro Pro Val Leu Ala Ser Pro Ala Gly His 
    50                  55                  60                  


Leu Pro 
65      


<210>  1141
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  1141

Met Glu Leu Gly Leu Gly Gly Leu Ser Thr Leu Ser His Cys Pro Trp 
1               5                   10                  15      


Pro Arg Gln Gln Pro Ala Leu Trp Pro Thr Leu Ala Ala Leu Ala Leu 
            20                  25                  30          


Leu Ser Ser Val Ala Glu Ala Ser Leu Gly Ser Ala Pro Arg Ser Pro 
        35                  40                  45              


Ala Pro Arg Glu Gly Pro Pro Pro Val Leu Ala Ser Pro Ala Gly His 
    50                  55                  60                  


Leu Pro 
65      


<210>  1142
<211>  220
<212>  PRT
<213>  Homo Sapiens

<400>  1142

Met Glu Leu Gly Leu Gly Gly Leu Ser Thr Leu Ser His Cys Pro Trp 
1               5                   10                  15      


Pro Arg Gln Gln Pro Ala Leu Trp Pro Thr Leu Ala Ala Leu Ala Leu 
            20                  25                  30          


Leu Ser Ser Val Ala Glu Ala Ser Leu Gly Ser Ala Pro Arg Ser Pro 
        35                  40                  45              


Ala Pro Arg Glu Gly Pro Pro Pro Val Leu Ala Ser Pro Ala Gly His 
    50                  55                  60                  


Leu Pro Gly Gly Arg Thr Ala Arg Trp Cys Ser Gly Arg Ala Arg Arg 
65                  70                  75                  80  


Pro Pro Pro Gln Pro Ser Arg Pro Ala Pro Pro Pro Pro Ala Pro Pro 
                85                  90                  95      


Ser Ala Leu Pro Arg Gly Gly Arg Ala Ala Arg Ala Gly Gly Pro Gly 
            100                 105                 110         


Ser Arg Ala Arg Ala Ala Gly Ala Arg Gly Cys Arg Leu Arg Ser Gln 
        115                 120                 125             


Leu Val Pro Val Arg Ala Leu Gly Leu Gly His Arg Ser Asp Glu Leu 
    130                 135                 140                 


Val Arg Phe Arg Phe Cys Ser Gly Ser Cys Arg Arg Ala Arg Ser Pro 
145                 150                 155                 160 


His Asp Leu Ser Leu Ala Ser Leu Leu Gly Ala Gly Ala Leu Arg Pro 
                165                 170                 175     


Pro Pro Gly Ser Arg Pro Val Ser Gln Pro Cys Cys Arg Pro Thr Arg 
            180                 185                 190         


Tyr Glu Ala Val Ser Phe Met Asp Val Asn Ser Thr Trp Arg Thr Val 
        195                 200                 205             


Asp Arg Leu Ser Ala Thr Ala Cys Gly Cys Leu Gly 
    210                 215                 220 


<210>  1143
<211>  220
<212>  PRT
<213>  Homo Sapiens

<400>  1143

Met Glu Leu Gly Leu Gly Gly Leu Ser Thr Leu Ser His Cys Pro Trp 
1               5                   10                  15      


Pro Arg Gln Gln Pro Ala Leu Trp Pro Thr Leu Ala Ala Leu Ala Leu 
            20                  25                  30          


Leu Ser Ser Val Ala Glu Ala Ser Leu Gly Ser Ala Pro Arg Ser Pro 
        35                  40                  45              


Ala Pro Arg Glu Gly Pro Pro Pro Val Leu Ala Ser Pro Ala Gly His 
    50                  55                  60                  


Leu Pro Gly Gly Arg Thr Ala Arg Trp Cys Ser Gly Arg Ala Arg Arg 
65                  70                  75                  80  


Pro Pro Pro Gln Pro Ser Arg Pro Ala Pro Pro Pro Pro Ala Pro Pro 
                85                  90                  95      


Ser Ala Leu Pro Arg Gly Gly Arg Ala Ala Arg Ala Gly Gly Pro Gly 
            100                 105                 110         


Ser Arg Ala Arg Ala Ala Gly Ala Arg Gly Cys Arg Leu Arg Ser Gln 
        115                 120                 125             


Leu Val Pro Val Arg Ala Leu Gly Leu Gly His Arg Ser Asp Glu Leu 
    130                 135                 140                 


Val Arg Phe Arg Phe Cys Ser Gly Ser Cys Arg Arg Ala Arg Ser Pro 
145                 150                 155                 160 


His Asp Leu Ser Leu Ala Ser Leu Leu Gly Ala Gly Ala Leu Arg Pro 
                165                 170                 175     


Pro Pro Gly Ser Arg Pro Val Ser Gln Pro Cys Cys Arg Pro Thr Arg 
            180                 185                 190         


Tyr Glu Ala Val Ser Phe Met Asp Val Asn Ser Thr Trp Arg Thr Val 
        195                 200                 205             


Asp Arg Leu Ser Ala Thr Ala Cys Gly Cys Leu Gly 
    210                 215                 220 


<210>  1144
<211>  237
<212>  PRT
<213>  Homo Sapiens

<400>  1144

Met Pro Gly Leu Ile Ser Ala Arg Gly Gln Pro Leu Leu Glu Val Leu 
1               5                   10                  15      


Pro Pro Gln Ala His Leu Gly Ala Leu Phe Leu Pro Glu Ala Pro Leu 
            20                  25                  30          


Gly Leu Ser Ala Gln Pro Ala Leu Trp Pro Thr Leu Ala Ala Leu Ala 
        35                  40                  45              


Leu Leu Ser Ser Val Ala Glu Ala Ser Leu Gly Ser Ala Pro Arg Ser 
    50                  55                  60                  


Pro Ala Pro Arg Glu Gly Pro Pro Pro Val Leu Ala Ser Pro Ala Gly 
65                  70                  75                  80  


His Leu Pro Gly Gly Arg Thr Ala Arg Trp Cys Ser Gly Arg Ala Arg 
                85                  90                  95      


Arg Pro Pro Pro Gln Pro Ser Arg Pro Ala Pro Pro Pro Pro Ala Pro 
            100                 105                 110         


Pro Ser Ala Leu Pro Arg Gly Gly Arg Ala Ala Arg Ala Gly Gly Pro 
        115                 120                 125             


Gly Ser Arg Ala Arg Ala Ala Gly Ala Arg Gly Cys Arg Leu Arg Ser 
    130                 135                 140                 


Gln Leu Val Pro Val Arg Ala Leu Gly Leu Gly His Arg Ser Asp Glu 
145                 150                 155                 160 


Leu Val Arg Phe Arg Phe Cys Ser Gly Ser Cys Arg Arg Ala Arg Ser 
                165                 170                 175     


Pro His Asp Leu Ser Leu Ala Ser Leu Leu Gly Ala Gly Ala Leu Arg 
            180                 185                 190         


Pro Pro Pro Gly Ser Arg Pro Val Ser Gln Pro Cys Cys Arg Pro Thr 
        195                 200                 205             


Arg Tyr Glu Ala Val Ser Phe Met Asp Val Asn Ser Thr Trp Arg Thr 
    210                 215                 220                 


Val Asp Arg Leu Ser Ala Thr Ala Cys Gly Cys Leu Gly 
225                 230                 235         


<210>  1145
<211>  31
<212>  PRT
<213>  Homo Sapiens

<400>  1145

Gly Arg Ala Val Asp Arg Gly Leu Gln Lys Ile Asn Leu Ser Ser Phe 
1               5                   10                  15      


Arg Thr Asn Val Gln Arg Cys Ser Ser Met Val His His Lys Ser 
            20                  25                  30      


<210>  1146
<211>  125
<212>  PRT
<213>  Homo Sapiens

<400>  1146

Met Leu Asp Lys Ala Pro Val Leu Lys Val Ile Val Asn Ser Leu Lys 
1               5                   10                  15      


Asn Met Ile Asn Thr Phe Val Pro Ser Gly Lys Ile Met Gln Val Val 
            20                  25                  30          


Asp Glu Lys Leu Pro Gly Leu Leu Gly Asn Phe Pro Gly Pro Phe Glu 
        35                  40                  45              


Glu Glu Met Lys Gly Ile Ala Ala Val Thr Asp Ile Pro Leu Gly Glu 
    50                  55                  60                  


Ile Ile Ser Phe Asn Ile Phe Tyr Glu Leu Phe Thr Ile Cys Thr Ser 
65                  70                  75                  80  


Ile Val Ala Glu Asp Lys Lys Gly His Leu Ile His Gly Arg Asn Met 
                85                  90                  95      


Asp Phe Gly Val Phe Leu Gly Trp Asn Ile Asn Asn Asp Thr Trp Val 
            100                 105                 110         


Ile Thr Glu Gln Leu Lys Pro Leu Thr Val Asn Leu Asp 
        115                 120                 125 


<210>  1147
<211>  151
<212>  PRT
<213>  Homo Sapiens

<400>  1147

Met Leu Asp Lys Ala Pro Val Leu Lys Val Ile Val Asn Ser Leu Lys 
1               5                   10                  15      


Asn Met Ile Asn Thr Phe Val Pro Ser Gly Lys Ile Met Gln Val Val 
            20                  25                  30          


Asp Glu Lys Leu Pro Gly Leu Leu Gly Asn Phe Pro Gly Pro Phe Glu 
        35                  40                  45              


Glu Glu Met Lys Gly Ile Ala Ala Val Thr Asp Ile Pro Leu Gly Glu 
    50                  55                  60                  


Ile Ile Ser Phe Asn Ile Phe Tyr Glu Leu Phe Thr Ile Cys Thr Ser 
65                  70                  75                  80  


Ile Val Ala Glu Asp Lys Lys Gly His Leu Ile His Gly Arg Asn Met 
                85                  90                  95      


Asp Phe Gly Val Phe Leu Gly Trp Asn Ile Asn Asn Asp Thr Trp Val 
            100                 105                 110         


Ile Thr Glu Gln Leu Lys Pro Leu Thr Val Asn Leu Asp Phe Gln Arg 
        115                 120                 125             


Asn Asn Lys Thr Val Phe Lys Ala Ser Ser Phe Ala Gly Tyr Val Gly 
    130                 135                 140                 


Met Leu Thr Gly Phe Lys Pro 
145                 150     


<210>  1148
<211>  330
<212>  PRT
<213>  Homo Sapiens

<400>  1148

Met Leu Asp Lys Ala Pro Val Leu Lys Val Ile Val Asn Ser Leu Lys 
1               5                   10                  15      


Asn Met Ile Asn Thr Phe Val Pro Ser Gly Lys Ile Met Gln Val Val 
            20                  25                  30          


Asp Glu Lys Leu Pro Gly Leu Leu Gly Asn Phe Pro Gly Pro Phe Glu 
        35                  40                  45              


Glu Glu Met Lys Gly Ile Ala Ala Val Thr Asp Ile Pro Leu Gly Glu 
    50                  55                  60                  


Ile Ile Ser Phe Asn Ile Phe Tyr Glu Leu Phe Thr Ile Cys Thr Ser 
65                  70                  75                  80  


Ile Val Ala Glu Asp Lys Lys Gly His Leu Ile His Gly Arg Asn Met 
                85                  90                  95      


Asp Phe Gly Val Phe Leu Gly Trp Asn Ile Asn Asn Asp Thr Trp Val 
            100                 105                 110         


Ile Thr Glu Gln Leu Lys Pro Leu Thr Val Asn Leu Asp Phe Gln Arg 
        115                 120                 125             


Asn Asn Lys Thr Val Phe Lys Ala Ser Ser Phe Ala Gly Tyr Val Gly 
    130                 135                 140                 


Met Leu Thr Gly Phe Lys Pro Gly Leu Phe Ser Leu Thr Leu Asn Glu 
145                 150                 155                 160 


Arg Phe Ser Ile Asn Gly Gly Tyr Leu Gly Ile Leu Glu Trp Ile Leu 
                165                 170                 175     


Gly Lys Lys Asp Val Met Trp Ile Gly Phe Leu Thr Arg Thr Val Leu 
            180                 185                 190         


Glu Asn Ser Thr Ser Tyr Glu Glu Ala Lys Asn Leu Leu Thr Lys Thr 
        195                 200                 205             


Lys Ile Leu Ala Pro Ala Tyr Phe Ile Leu Gly Gly Asn Gln Ser Gly 
    210                 215                 220                 


Glu Gly Cys Val Ile Thr Arg Asp Arg Lys Glu Ser Leu Asp Val Tyr 
225                 230                 235                 240 


Glu Leu Asp Ala Lys Gln Gly Arg Trp Tyr Val Val Gln Thr Asn Tyr 
                245                 250                 255     


Asp Arg Trp Lys His Pro Phe Phe Leu Asp Asp Arg Arg Thr Pro Ala 
            260                 265                 270         


Lys Met Cys Leu Asn Arg Thr Ser Gln Glu Asn Ile Ser Phe Glu Thr 
        275                 280                 285             


Met Tyr Asp Val Leu Ser Thr Lys Pro Val Leu Asn Lys Leu Thr Val 
    290                 295                 300                 


Tyr Thr Thr Leu Ile Asp Val Thr Lys Gly Gln Phe Glu Thr Tyr Leu 
305                 310                 315                 320 


Arg Asp Cys Pro Asp Pro Cys Ile Gly Trp 
                325                 330 


<210>  1149
<211>  330
<212>  PRT
<213>  Homo Sapiens

<400>  1149

Met Leu Asp Lys Ala Pro Val Leu Lys Val Ile Val Asn Ser Leu Lys 
1               5                   10                  15      


Asn Met Ile Asn Thr Phe Val Pro Ser Gly Lys Ile Met Gln Val Val 
            20                  25                  30          


Asp Glu Lys Leu Pro Gly Leu Leu Gly Asn Phe Pro Gly Pro Phe Glu 
        35                  40                  45              


Glu Glu Met Lys Gly Ile Ala Ala Val Thr Asp Ile Pro Leu Gly Glu 
    50                  55                  60                  


Ile Ile Ser Phe Asn Ile Phe Tyr Glu Leu Phe Thr Ile Cys Thr Ser 
65                  70                  75                  80  


Ile Val Ala Glu Asp Lys Lys Gly His Leu Ile His Gly Arg Asn Met 
                85                  90                  95      


Asp Phe Gly Val Phe Leu Gly Trp Asn Ile Asn Asn Asp Thr Trp Val 
            100                 105                 110         


Ile Thr Glu Gln Leu Lys Pro Leu Thr Val Asn Leu Asp Phe Gln Arg 
        115                 120                 125             


Asn Asn Lys Thr Val Phe Lys Ala Ser Ser Phe Ala Gly Tyr Val Gly 
    130                 135                 140                 


Met Leu Thr Gly Phe Lys Pro Gly Leu Phe Ser Leu Thr Leu Asn Glu 
145                 150                 155                 160 


Arg Phe Ser Ile Asn Gly Gly Tyr Leu Gly Ile Leu Glu Trp Ile Leu 
                165                 170                 175     


Gly Lys Lys Asp Val Met Trp Ile Gly Phe Leu Thr Arg Thr Val Leu 
            180                 185                 190         


Glu Asn Ser Thr Ser Tyr Glu Glu Ala Lys Asn Leu Leu Thr Lys Thr 
        195                 200                 205             


Lys Ile Leu Ala Pro Ala Tyr Phe Ile Leu Gly Gly Asn Gln Ser Gly 
    210                 215                 220                 


Glu Gly Cys Val Ile Thr Arg Asp Arg Lys Glu Ser Leu Asp Val Tyr 
225                 230                 235                 240 


Glu Leu Asp Ala Lys Gln Gly Arg Trp Tyr Val Val Gln Thr Asn Tyr 
                245                 250                 255     


Asp Arg Trp Lys His Pro Phe Phe Leu Asp Asp Arg Arg Thr Pro Ala 
            260                 265                 270         


Lys Met Cys Leu Asn Arg Thr Ser Gln Glu Asn Ile Ser Phe Glu Thr 
        275                 280                 285             


Met Tyr Asp Val Leu Ser Thr Lys Pro Val Leu Asn Lys Leu Thr Val 
    290                 295                 300                 


Tyr Thr Thr Leu Ile Asp Val Thr Lys Gly Gln Phe Glu Thr Tyr Leu 
305                 310                 315                 320 


Arg Asp Cys Pro Asp Pro Cys Ile Gly Trp 
                325                 330 


<210>  1150
<211>  110
<212>  PRT
<213>  Homo Sapiens

<400>  1150

Met Leu Asp Lys Ala Pro Val Leu Lys Val Ile Val Asn Ser Leu Lys 
1               5                   10                  15      


Asn Met Ile Asn Thr Phe Val Pro Ser Gly Lys Ile Met Gln Val Val 
            20                  25                  30          


Asp Glu Lys Leu Pro Gly Leu Leu Gly Asn Phe Pro Gly Pro Phe Glu 
        35                  40                  45              


Glu Glu Met Lys Gly Ile Ala Ala Val Thr Asp Ile Pro Leu Gly Lys 
    50                  55                  60                  


Val His Leu Glu Ala Leu Lys Lys Lys Val Ile Lys Phe Phe Tyr Lys 
65                  70                  75                  80  


Phe Pro Leu Arg Cys Asp Ile His Thr Ala Gln Val Leu Tyr Val Leu 
                85                  90                  95      


Asp Ile Gln His Arg Cys Thr Gly Leu Arg Tyr Thr Ala Gln 
            100                 105                 110 


<210>  1151
<211>  110
<212>  PRT
<213>  Homo Sapiens

<400>  1151

Met Leu Asp Lys Ala Pro Val Leu Lys Val Ile Val Asn Ser Leu Lys 
1               5                   10                  15      


Asn Met Ile Asn Thr Phe Val Pro Ser Gly Lys Ile Met Gln Val Val 
            20                  25                  30          


Asp Glu Lys Leu Pro Gly Leu Leu Gly Asn Phe Pro Gly Pro Phe Glu 
        35                  40                  45              


Glu Glu Met Lys Gly Ile Ala Ala Val Thr Asp Ile Pro Leu Gly Lys 
    50                  55                  60                  


Val His Leu Glu Ala Leu Lys Lys Lys Val Ile Lys Phe Phe Tyr Lys 
65                  70                  75                  80  


Phe Pro Leu Arg Cys Asp Ile His Thr Ala Gln Val Leu Tyr Val Leu 
                85                  90                  95      


Asp Ile Gln His Arg Cys Thr Gly Leu Arg Tyr Thr Ala Gln 
            100                 105                 110 


<210>  1152
<211>  187
<212>  PRT
<213>  Homo Sapiens

<400>  1152

Met Asn Cys Cys Ile Gly Leu Gly Glu Lys Ala Arg Gly Ser His Arg 
1               5                   10                  15      


Ala Ser Tyr Pro Ser Leu Ser Ala Leu Phe Thr Glu Ala Ser Ile Leu 
            20                  25                  30          


Gly Phe Gly Ser Phe Ala Val Lys Ala Gln Val Ala Trp Lys Ala Leu 
        35                  40                  45              


Ser Leu Ser Leu Arg His Pro Phe Arg Gly Thr Glu Lys Pro Arg Pro 
    50                  55                  60                  


Leu Leu Pro Val Pro Pro Pro Pro Ser Val Pro Pro Thr Ala Trp Asn 
65                  70                  75                  80  


Gly Ala Val Pro Gly Arg Gly Ser Arg Gly Gly Gly Gly Val Ala Cys 
                85                  90                  95      


Pro Arg Pro Ser Arg Leu Phe Phe Ala Ser Ala Gly Val Arg Gly Val 
            100                 105                 110         


Ala Leu Ala Ala Arg Ala Met Pro Gly Arg Ser Cys Val Ala Leu Val 
        115                 120                 125             


Leu Leu Ala Ala Ala Val Ser Cys Ala Val Ala Gln His Ala Pro Pro 
    130                 135                 140                 


Trp Thr Glu Asp Cys Arg Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr 
145                 150                 155                 160 


Tyr Arg Gly Ala Val Pro Trp Tyr Thr Ile Asn Leu Asp Leu Pro Pro 
                165                 170                 175     


Tyr Lys Arg Trp His Glu Leu Met Leu Asp Lys 
            180                 185         


<210>  1153
<211>  72
<212>  PRT
<213>  Homo Sapiens

<400>  1153

Met Asn Cys Cys Ile Gly Leu Gly Glu Lys Ala Arg Gly Ser His Arg 
1               5                   10                  15      


Ala Ser Tyr Pro Ser Leu Ser Ala Leu Phe Thr Glu Ala Ser Ile Leu 
            20                  25                  30          


Gly Phe Gly Ser Phe Ala Val Lys Ala Gln Val Gly Asn Gln Gln Leu 
        35                  40                  45              


Gly Gly Pro Glu Trp Ile Arg Phe Ser Leu Thr Pro Arg Pro Leu Asn 
    50                  55                  60                  


Cys Ser Leu Ser Leu Thr Pro Arg 
65                  70          


<210>  1154
<211>  97
<212>  PRT
<213>  Homo Sapiens

<400>  1154

Met Asn Cys Cys Ile Gly Leu Gly Glu Lys Ala Arg Gly Ser His Arg 
1               5                   10                  15      


Ala Ser Tyr Pro Ser Leu Ser Ala Leu Phe Thr Glu Ala Ser Ile Leu 
            20                  25                  30          


Gly Phe Gly Ser Phe Ala Val Lys Ala Gln Val Gly Asn Gln Gln Leu 
        35                  40                  45              


Gly Gly Pro Glu Trp Ile Arg Phe Ser Leu Thr Pro Arg Pro Leu Asn 
    50                  55                  60                  


Cys Ser Leu Ser Leu Thr Pro Arg Gly Gln Arg Thr Ala Glu Asn Gln 
65                  70                  75                  80  


Pro Ile Leu Leu Gln Asp Gln Arg Thr Glu Val Gln Phe His Gly Thr 
                85                  90                  95      


Pro 
    


<210>  1155
<211>  74
<212>  PRT
<213>  Homo Sapiens

<400>  1155

Met Asn Cys Cys Ile Gly Leu Gly Glu Lys Ala Arg Gly Ser His Arg 
1               5                   10                  15      


Ala Ser Tyr Pro Ser Leu Ser Ala Leu Phe Thr Glu Ala Ser Ile Leu 
            20                  25                  30          


Gly Phe Gly Ser Phe Ala Val Lys Ala Gln Val Gly Asn Gln Gln Leu 
        35                  40                  45              


Gly Gly Pro Glu Trp Ile Arg Phe Ser Leu Thr Pro Arg Pro Leu Asn 
    50                  55                  60                  


Cys Ser Leu Ser Leu Thr Pro Arg Trp Gly 
65                  70                  


<210>  1156
<211>  74
<212>  PRT
<213>  Homo Sapiens

<400>  1156

Met Asn Cys Cys Ile Gly Leu Gly Glu Lys Ala Arg Gly Ser His Arg 
1               5                   10                  15      


Ala Ser Tyr Pro Ser Leu Ser Ala Leu Phe Thr Glu Ala Ser Ile Leu 
            20                  25                  30          


Gly Phe Gly Ser Phe Ala Val Lys Ala Gln Val Gly Asn Gln Gln Leu 
        35                  40                  45              


Gly Gly Pro Glu Trp Ile Arg Phe Ser Leu Thr Pro Arg Pro Leu Asn 
    50                  55                  60                  


Cys Ser Leu Ser Leu Thr Pro Arg Trp Gly 
65                  70                  


<210>  1157
<211>  74
<212>  PRT
<213>  Homo Sapiens

<400>  1157

Met Asn Cys Cys Ile Gly Leu Gly Glu Lys Ala Arg Gly Ser His Arg 
1               5                   10                  15      


Ala Ser Tyr Pro Ser Leu Ser Ala Leu Phe Thr Glu Ala Ser Ile Leu 
            20                  25                  30          


Gly Phe Gly Ser Phe Ala Val Lys Ala Gln Val Gly Asn Gln Gln Leu 
        35                  40                  45              


Gly Gly Pro Glu Trp Ile Arg Phe Ser Leu Thr Pro Arg Pro Leu Asn 
    50                  55                  60                  


Cys Ser Leu Ser Leu Thr Pro Arg Trp Gly 
65                  70                  


<210>  1158
<211>  74
<212>  PRT
<213>  Homo Sapiens

<400>  1158

Met Asn Cys Cys Ile Gly Leu Gly Glu Lys Ala Arg Gly Ser His Arg 
1               5                   10                  15      


Ala Ser Tyr Pro Ser Leu Ser Ala Leu Phe Thr Glu Ala Ser Ile Leu 
            20                  25                  30          


Gly Phe Gly Ser Phe Ala Val Lys Ala Gln Val Gly Asn Gln Gln Leu 
        35                  40                  45              


Gly Gly Pro Glu Trp Ile Arg Phe Ser Leu Thr Pro Arg Pro Leu Asn 
    50                  55                  60                  


Cys Ser Leu Ser Leu Thr Pro Arg Trp Gly 
65                  70                  


<210>  1159
<211>  74
<212>  PRT
<213>  Homo Sapiens

<400>  1159

Met Asn Cys Cys Ile Gly Leu Gly Glu Lys Ala Arg Gly Ser His Arg 
1               5                   10                  15      


Ala Ser Tyr Pro Ser Leu Ser Ala Leu Phe Thr Glu Ala Ser Ile Leu 
            20                  25                  30          


Gly Phe Gly Ser Phe Ala Val Lys Ala Gln Val Gly Asn Gln Gln Leu 
        35                  40                  45              


Gly Gly Pro Glu Trp Ile Arg Phe Ser Leu Thr Pro Arg Pro Leu Asn 
    50                  55                  60                  


Cys Ser Leu Ser Leu Thr Pro Arg Trp Gly 
65                  70                  


<210>  1160
<211>  71
<212>  PRT
<213>  Homo Sapiens

<400>  1160

Met Asn Cys Cys Ile Gly Leu Gly Glu Lys Ala Arg Gly Ser His Arg 
1               5                   10                  15      


Ala Ser Tyr Pro Ser Leu Ser Ala Leu Phe Thr Glu Ala Ser Ile Leu 
            20                  25                  30          


Gly Phe Gly Ser Phe Ala Val Lys Ala Gln Val Val Asp Arg Gly Leu 
        35                  40                  45              


Gln Lys Ile Asn Leu Ser Ser Phe Arg Thr Asn Val Gln Arg Cys Ser 
    50                  55                  60                  


Ser Met Val His His Lys Ser 
65                  70      


<210>  1161
<211>  58
<212>  PRT
<213>  Homo Sapiens

<400>  1161

Met Asn Cys Cys Ile Gly Leu Gly Glu Lys Ala Arg Gly Ser His Arg 
1               5                   10                  15      


Ala Ser Tyr Pro Ser Leu Ser Ala Leu Phe Thr Glu Ala Ser Ile Leu 
            20                  25                  30          


Gly Phe Gly Ser Phe Ala Val Lys Ala Gln Trp Thr Glu Asp Cys Arg 
        35                  40                  45              


Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr 
    50                  55              


<210>  1162
<211>  59
<212>  PRT
<213>  Homo Sapiens

<400>  1162

Met Asn Cys Cys Ile Gly Leu Gly Glu Lys Ala Arg Gly Ser His Arg 
1               5                   10                  15      


Ala Ser Tyr Pro Ser Leu Ser Ala Leu Phe Thr Glu Ala Ser Ile Leu 
            20                  25                  30          


Gly Phe Gly Ser Phe Ala Val Lys Ala Gln Trp Thr Glu Asp Cys Arg 
        35                  40                  45              


Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr Leu 
    50                  55                  


<210>  1163
<211>  389
<212>  PRT
<213>  Homo Sapiens

<400>  1163

Met Asn Cys Cys Ile Gly Leu Gly Glu Lys Ala Arg Gly Ser His Arg 
1               5                   10                  15      


Ala Ser Tyr Pro Ser Leu Ser Ala Leu Phe Thr Glu Ala Ser Ile Leu 
            20                  25                  30          


Gly Phe Gly Ser Phe Ala Val Lys Ala Gln Trp Thr Glu Asp Cys Arg 
        35                  40                  45              


Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr Val Phe Pro Ala Val Ile 
    50                  55                  60                  


Arg Tyr Arg Gly Ala Val Pro Trp Tyr Thr Ile Asn Leu Asp Leu Pro 
65                  70                  75                  80  


Pro Tyr Lys Arg Trp His Glu Leu Met Leu Asp Lys Ala Pro Val Pro 
                85                  90                  95      


Gly Leu Leu Gly Asn Phe Pro Gly Pro Phe Glu Glu Glu Met Lys Gly 
            100                 105                 110         


Ile Ala Ala Val Thr Asp Ile Pro Leu Gly Glu Ile Ile Ser Phe Asn 
        115                 120                 125             


Ile Phe Tyr Glu Leu Phe Thr Ile Cys Thr Ser Ile Val Ala Glu Asp 
    130                 135                 140                 


Lys Lys Gly His Leu Ile His Gly Arg Asn Met Asp Phe Gly Val Phe 
145                 150                 155                 160 


Leu Gly Trp Asn Ile Asn Asn Asp Thr Trp Val Ile Thr Glu Gln Leu 
                165                 170                 175     


Lys Pro Leu Thr Val Asn Leu Asp Phe Gln Arg Asn Asn Lys Thr Val 
            180                 185                 190         


Phe Lys Ala Ser Ser Phe Ala Gly Tyr Val Gly Met Leu Thr Gly Phe 
        195                 200                 205             


Lys Pro Gly Leu Phe Ser Leu Thr Leu Asn Glu Arg Phe Ser Ile Asn 
    210                 215                 220                 


Gly Gly Tyr Leu Gly Ile Leu Glu Trp Ile Leu Gly Lys Lys Asp Val 
225                 230                 235                 240 


Met Trp Ile Gly Phe Leu Thr Arg Thr Val Leu Glu Asn Ser Thr Ser 
                245                 250                 255     


Tyr Glu Glu Ala Lys Asn Leu Leu Thr Lys Thr Lys Ile Leu Ala Pro 
            260                 265                 270         


Ala Tyr Phe Ile Leu Gly Gly Asn Gln Ser Gly Glu Gly Cys Val Ile 
        275                 280                 285             


Thr Arg Asp Arg Lys Glu Ser Leu Asp Val Tyr Glu Leu Asp Ala Lys 
    290                 295                 300                 


Gln Gly Arg Trp Tyr Val Val Gln Thr Asn Tyr Asp Arg Trp Lys His 
305                 310                 315                 320 


Pro Phe Phe Leu Asp Asp Arg Arg Thr Pro Ala Lys Met Cys Leu Asn 
                325                 330                 335     


Arg Thr Ser Gln Glu Asn Ile Ser Phe Glu Thr Met Tyr Asp Val Leu 
            340                 345                 350         


Ser Thr Lys Pro Val Leu Asn Lys Leu Thr Val Tyr Thr Thr Leu Ile 
        355                 360                 365             


Asp Val Thr Lys Gly Gln Phe Glu Thr Tyr Leu Arg Asp Cys Pro Asp 
    370                 375                 380                 


Pro Cys Ile Gly Trp 
385                 


<210>  1164
<211>  411
<212>  PRT
<213>  Homo Sapiens

<400>  1164

Met Asn Cys Cys Ile Gly Leu Gly Glu Lys Ala Arg Gly Ser His Arg 
1               5                   10                  15      


Ala Ser Tyr Pro Ser Leu Ser Ala Leu Phe Thr Glu Ala Ser Ile Leu 
            20                  25                  30          


Gly Phe Gly Ser Phe Ala Val Lys Ala Gln Trp Thr Glu Asp Cys Arg 
        35                  40                  45              


Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr Tyr Arg Gly Ala Val Pro 
    50                  55                  60                  


Trp Tyr Thr Ile Asn Leu Asp Leu Pro Pro Tyr Lys Arg Trp His Glu 
65                  70                  75                  80  


Leu Met Leu Asp Lys Ala Pro Val Leu Lys Val Ile Val Asn Ser Leu 
                85                  90                  95      


Lys Asn Met Ile Asn Thr Phe Val Pro Ser Gly Lys Ile Met Gln Val 
            100                 105                 110         


Val Asp Glu Lys Leu Pro Gly Leu Leu Gly Asn Phe Pro Gly Pro Phe 
        115                 120                 125             


Glu Glu Glu Met Lys Gly Ile Ala Ala Val Thr Asp Ile Pro Leu Gly 
    130                 135                 140                 


Glu Ile Ile Ser Phe Asn Ile Phe Tyr Glu Leu Phe Thr Ile Cys Thr 
145                 150                 155                 160 


Ser Ile Val Ala Glu Asp Lys Lys Gly His Leu Ile His Gly Arg Asn 
                165                 170                 175     


Met Asp Phe Gly Val Phe Leu Gly Trp Asn Ile Asn Asn Asp Thr Trp 
            180                 185                 190         


Val Ile Thr Glu Gln Leu Lys Pro Leu Thr Val Asn Leu Asp Phe Gln 
        195                 200                 205             


Arg Asn Asn Lys Thr Val Phe Lys Ala Ser Ser Phe Ala Gly Tyr Val 
    210                 215                 220                 


Gly Met Leu Thr Gly Phe Lys Pro Gly Leu Phe Ser Leu Thr Leu Asn 
225                 230                 235                 240 


Glu Arg Phe Ser Ile Asn Gly Gly Tyr Leu Gly Ile Leu Glu Trp Ile 
                245                 250                 255     


Leu Gly Lys Lys Asp Val Met Trp Ile Gly Phe Leu Thr Arg Thr Val 
            260                 265                 270         


Leu Glu Asn Ser Thr Ser Tyr Glu Glu Ala Lys Asn Leu Leu Thr Lys 
        275                 280                 285             


Thr Lys Ile Leu Ala Pro Ala Tyr Phe Ile Leu Gly Gly Asn Gln Ser 
    290                 295                 300                 


Gly Glu Gly Cys Val Ile Thr Arg Asp Arg Lys Glu Ser Leu Asp Val 
305                 310                 315                 320 


Tyr Glu Leu Asp Ala Lys Gln Gly Arg Trp Tyr Val Val Gln Thr Asn 
                325                 330                 335     


Tyr Asp Arg Trp Lys His Pro Phe Phe Leu Asp Asp Arg Arg Thr Pro 
            340                 345                 350         


Ala Lys Met Cys Leu Asn Arg Thr Ser Gln Glu Asn Ile Ser Phe Glu 
        355                 360                 365             


Thr Met Tyr Asp Val Leu Ser Thr Lys Pro Val Leu Asn Lys Leu Thr 
    370                 375                 380                 


Val Tyr Thr Thr Leu Ile Asp Val Thr Lys Gly Gln Phe Glu Thr Tyr 
385                 390                 395                 400 


Leu Arg Asp Cys Pro Asp Pro Cys Ile Gly Trp 
                405                 410     


<210>  1165
<211>  341
<212>  PRT
<213>  Homo Sapiens

<400>  1165

Met Asn Cys Cys Ile Gly Leu Gly Glu Lys Ala Arg Gly Ser His Arg 
1               5                   10                  15      


Ala Ser Tyr Pro Ser Leu Ser Ala Leu Phe Thr Glu Ala Ser Ile Leu 
            20                  25                  30          


Gly Phe Gly Ser Phe Ala Val Lys Ala Gln Trp Thr Glu Asp Cys Arg 
        35                  40                  45              


Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr Tyr Arg Gly Ala Val Pro 
    50                  55                  60                  


Trp Tyr Thr Ile Asn Leu Asp Leu Pro Pro Tyr Lys Arg Trp His Glu 
65                  70                  75                  80  


Leu Met Leu Asp Lys Ala Pro Val Leu Lys Val Ile Val Asn Ser Leu 
                85                  90                  95      


Lys Asn Met Ile Asn Thr Phe Val Pro Ser Gly Lys Ile Met Gln Val 
            100                 105                 110         


Val Asp Glu Lys Leu Pro Gly Leu Leu Gly Asn Phe Pro Gly Pro Phe 
        115                 120                 125             


Glu Glu Glu Met Lys Gly Ile Ala Ala Val Thr Asp Ile Pro Leu Gly 
    130                 135                 140                 


Glu Ile Ile Ser Phe Asn Ile Phe Tyr Glu Leu Phe Thr Ile Cys Thr 
145                 150                 155                 160 


Ser Ile Val Ala Glu Asp Lys Lys Gly His Leu Ile His Gly Arg Asn 
                165                 170                 175     


Met Asp Phe Gly Val Phe Leu Gly Trp Asn Ile Asn Asn Asp Thr Trp 
            180                 185                 190         


Val Ile Thr Glu Gln Leu Lys Pro Leu Thr Val Asn Leu Asp Phe Gln 
        195                 200                 205             


Arg Asn Asn Lys Thr Val Phe Lys Ala Ser Ser Phe Ala Gly Tyr Val 
    210                 215                 220                 


Gly Met Leu Thr Gly Phe Lys Pro Gly Leu Phe Ser Leu Thr Leu Asn 
225                 230                 235                 240 


Glu Arg Phe Ser Ile Asn Gly Gly Tyr Leu Gly Ile Leu Glu Trp Ile 
                245                 250                 255     


Leu Gly Lys Lys Asp Val Met Trp Ile Gly Phe Leu Thr Arg Thr Val 
            260                 265                 270         


Leu Glu Asn Ser Thr Ser Tyr Glu Glu Ala Lys Asn Leu Leu Thr Lys 
        275                 280                 285             


Thr Lys Ile Leu Ala Pro Ala Tyr Phe Ile Leu Gly Gly Asn Gln Ser 
    290                 295                 300                 


Gly Glu Gly Cys Val Ile Thr Arg Asp Arg Lys Glu Ser Leu Asp Val 
305                 310                 315                 320 


Tyr Glu Ile Ser His Leu Lys Pro Cys Met Met Ser Cys Gln Gln Asn 
                325                 330                 335     


Leu Ser Ser Thr Ser 
            340     


<210>  1166
<211>  386
<212>  PRT
<213>  Homo Sapiens

<400>  1166

Met Asn Cys Cys Ile Gly Leu Gly Glu Lys Ala Arg Gly Ser His Arg 
1               5                   10                  15      


Ala Ser Tyr Pro Ser Leu Ser Ala Leu Phe Thr Glu Ala Ser Ile Leu 
            20                  25                  30          


Gly Phe Gly Ser Phe Ala Val Lys Ala Gln Trp Thr Glu Asp Cys Arg 
        35                  40                  45              


Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr Tyr Arg Gly Ala Val Pro 
    50                  55                  60                  


Trp Tyr Thr Ile Asn Leu Asp Leu Pro Pro Tyr Lys Arg Trp His Glu 
65                  70                  75                  80  


Leu Met Leu Asp Lys Ala Pro Val Leu Lys Val Ile Val Asn Ser Leu 
                85                  90                  95      


Lys Asn Met Ile Asn Thr Phe Val Pro Ser Gly Lys Ile Met Gln Val 
            100                 105                 110         


Val Asp Glu Lys Leu Pro Gly Leu Leu Gly Asn Phe Pro Gly Pro Phe 
        115                 120                 125             


Glu Glu Glu Met Lys Gly Ile Ala Ala Val Thr Asp Ile Pro Leu Gly 
    130                 135                 140                 


His Leu Ile His Gly Arg Asn Met Asp Phe Gly Val Phe Leu Gly Trp 
145                 150                 155                 160 


Asn Ile Asn Asn Asp Thr Trp Val Ile Thr Glu Gln Leu Lys Pro Leu 
                165                 170                 175     


Thr Val Asn Leu Asp Phe Gln Arg Asn Asn Lys Thr Val Phe Lys Ala 
            180                 185                 190         


Ser Ser Phe Ala Gly Tyr Val Gly Met Leu Thr Gly Phe Lys Pro Gly 
        195                 200                 205             


Leu Phe Ser Leu Thr Leu Asn Glu Arg Phe Ser Ile Asn Gly Gly Tyr 
    210                 215                 220                 


Leu Gly Ile Leu Glu Trp Ile Leu Gly Lys Lys Asp Val Met Trp Ile 
225                 230                 235                 240 


Gly Phe Leu Thr Arg Thr Val Leu Glu Asn Ser Thr Ser Tyr Glu Glu 
                245                 250                 255     


Ala Lys Asn Leu Leu Thr Lys Thr Lys Ile Leu Ala Pro Ala Tyr Phe 
            260                 265                 270         


Ile Leu Gly Gly Asn Gln Ser Gly Glu Gly Cys Val Ile Thr Arg Asp 
        275                 280                 285             


Arg Lys Glu Ser Leu Asp Val Tyr Glu Leu Asp Ala Lys Gln Gly Arg 
    290                 295                 300                 


Trp Tyr Val Val Gln Thr Asn Tyr Asp Arg Trp Lys His Pro Phe Phe 
305                 310                 315                 320 


Leu Asp Asp Arg Arg Thr Pro Ala Lys Met Cys Leu Asn Arg Thr Ser 
                325                 330                 335     


Gln Glu Asn Ile Ser Phe Glu Thr Met Tyr Asp Val Leu Ser Thr Lys 
            340                 345                 350         


Pro Val Leu Asn Lys Leu Thr Val Tyr Thr Thr Leu Ile Asp Val Thr 
        355                 360                 365             


Lys Gly Gln Phe Glu Thr Tyr Leu Arg Asp Cys Pro Asp Pro Cys Ile 
    370                 375                 380                 


Gly Trp 
385     


<210>  1167
<211>  191
<212>  PRT
<213>  Homo Sapiens

<400>  1167

Met Asn Cys Cys Ile Gly Leu Gly Glu Lys Ala Arg Gly Ser His Arg 
1               5                   10                  15      


Ala Ser Tyr Pro Ser Leu Ser Ala Leu Phe Thr Glu Ala Ser Ile Leu 
            20                  25                  30          


Gly Phe Gly Ser Phe Ala Val Lys Ala Gln Trp Thr Glu Asp Cys Arg 
        35                  40                  45              


Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr Tyr Arg Gly Ala Val Pro 
    50                  55                  60                  


Trp Tyr Thr Ile Asn Leu Asp Leu Pro Pro Tyr Lys Arg Trp His Glu 
65                  70                  75                  80  


Leu Met Leu Asp Lys Ala Pro Val Leu Lys Val Ile Val Asn Ser Leu 
                85                  90                  95      


Lys Asn Met Ile Asn Thr Phe Val Pro Ser Gly Lys Ile Met Gln Val 
            100                 105                 110         


Val Asp Glu Lys Leu Pro Gly Leu Leu Gly Asn Phe Pro Gly Pro Phe 
        115                 120                 125             


Glu Glu Glu Met Lys Gly Ile Ala Ala Val Thr Asp Ile Pro Leu Gly 
    130                 135                 140                 


Lys Val His Leu Glu Ala Leu Lys Lys Lys Val Ile Lys Phe Phe Tyr 
145                 150                 155                 160 


Lys Phe Pro Leu Arg Cys Asp Ile His Thr Ala Gln Val Leu Tyr Val 
                165                 170                 175     


Leu Asp Ile Gln His Arg Cys Thr Gly Leu Arg Tyr Thr Ala Gln 
            180                 185                 190     


<210>  1168
<211>  140
<212>  PRT
<213>  Homo Sapiens

<400>  1168

Met Asn Cys Cys Ile Gly Leu Gly Glu Lys Ala Arg Gly Ser His Arg 
1               5                   10                  15      


Ala Ser Tyr Pro Ser Leu Ser Ala Leu Phe Thr Glu Ala Ser Ile Leu 
            20                  25                  30          


Gly Phe Gly Ser Phe Ala Val Lys Ala Gln Trp Thr Glu Asp Cys Arg 
        35                  40                  45              


Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr Tyr Arg Gly Ala Val Pro 
    50                  55                  60                  


Trp Tyr Thr Ile Asn Leu Asp Leu Pro Pro Tyr Lys Arg Trp His Glu 
65                  70                  75                  80  


Leu Met Leu Asp Lys Ala Pro Val Val Ile Val Asn Ser Leu Lys Asn 
                85                  90                  95      


Met Ile Asn Thr Phe Val Pro Ser Gly Lys Ile Met Gln Val Val Asp 
            100                 105                 110         


Glu Lys Leu Pro Gly Leu Leu Gly Asn Phe Pro Gly Pro Phe Glu Glu 
        115                 120                 125             


Glu Met Lys Gly Ile Ala Ala Val Thr Asp Ile Pro 
    130                 135                 140 


<210>  1169
<211>  49
<212>  PRT
<213>  Homo Sapiens

<400>  1169

Met Pro Gly Arg Ser Cys Val Ala Leu Val Leu Leu Ala Ala Ala Val 
1               5                   10                  15      


Ser Cys Ala Val Ala Gln His Ala Pro Pro Arg Thr Ala Glu Asn Gln 
            20                  25                  30          


Pro Ile Leu Leu Gln Asp Gln Arg Thr Glu Val Gln Phe His Gly Thr 
        35                  40                  45              


Pro 
    


<210>  1170
<211>  81
<212>  PRT
<213>  Homo Sapiens

<400>  1170

Met Pro Gly Arg Ser Cys Val Ala Leu Val Leu Leu Ala Ala Ala Val 
1               5                   10                  15      


Ser Cys Ala Val Ala Gln His Ala Pro Pro Val Ser Glu Leu Glu Pro 
            20                  25                  30          


Arg Arg Arg Glu Gly Arg Ala Gly Ala Gly Ala Asp Gly Gly Ala Gly 
        35                  40                  45              


Val Ala Ala Arg Ala Val Asp Arg Gly Leu Gln Lys Ile Asn Leu Ser 
    50                  55                  60                  


Ser Phe Arg Thr Asn Val Gln Arg Cys Ser Ser Met Val His His Lys 
65                  70                  75                  80  


Ser 
    


<210>  1171
<211>  75
<212>  PRT
<213>  Homo Sapiens

<400>  1171

Met Pro Gly Arg Ser Cys Val Ala Leu Val Leu Leu Ala Ala Ala Val 
1               5                   10                  15      


Ser Cys Ala Val Ala Gln His Ala Pro Pro Val Ser Glu Leu Glu Pro 
            20                  25                  30          


Arg Arg Arg Glu Gly Arg Ala Gly Ala Gly Ala Asp Gly Gly Ala Val 
        35                  40                  45              


Asp Arg Gly Leu Gln Lys Ile Asn Leu Ser Ser Phe Arg Thr Asn Val 
    50                  55                  60                  


Gln Arg Cys Ser Ser Met Val His His Lys Ser 
65                  70                  75  


<210>  1172
<211>  75
<212>  PRT
<213>  Homo Sapiens

<400>  1172

Met Pro Gly Arg Ser Cys Val Ala Leu Val Leu Leu Ala Ala Ala Val 
1               5                   10                  15      


Ser Cys Ala Val Ala Gln His Ala Pro Pro Val Ser Glu Leu Glu Pro 
            20                  25                  30          


Arg Arg Arg Glu Gly Arg Ala Gly Ala Gly Ala Asp Gly Gly Ala Val 
        35                  40                  45              


Asp Arg Gly Leu Gln Lys Ile Asn Leu Ser Ser Phe Arg Thr Asn Val 
    50                  55                  60                  


Gln Arg Cys Ser Ser Met Val His His Lys Ser 
65                  70                  75  


<210>  1173
<211>  67
<212>  PRT
<213>  Homo Sapiens

<400>  1173

Met Pro Gly Arg Ser Cys Val Ala Leu Val Leu Leu Ala Ala Ala Val 
1               5                   10                  15      


Ser Cys Ala Val Ala Gln His Ala Pro Pro Val Ser Glu Leu Glu Pro 
            20                  25                  30          


Arg Arg Arg Glu Gly Arg Ala Val Asp Arg Gly Leu Gln Lys Ile Asn 
        35                  40                  45              


Leu Ser Ser Phe Arg Thr Asn Val Gln Arg Cys Ser Ser Met Val His 
    50                  55                  60                  


His Lys Ser 
65          


<210>  1174
<211>  42
<212>  PRT
<213>  Homo Sapiens

<400>  1174

Met Pro Gly Arg Ser Cys Val Ala Leu Val Leu Leu Ala Ala Ala Val 
1               5                   10                  15      


Ser Cys Ala Val Ala Gln His Ala Pro Pro Trp Thr Glu Asp Cys Arg 
            20                  25                  30          


Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr 
        35                  40          


<210>  1175
<211>  42
<212>  PRT
<213>  Homo Sapiens

<400>  1175

Met Pro Gly Arg Ser Cys Val Ala Leu Val Leu Leu Ala Ala Ala Val 
1               5                   10                  15      


Ser Cys Ala Val Ala Gln His Ala Pro Pro Trp Thr Glu Asp Cys Arg 
            20                  25                  30          


Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr 
        35                  40          


<210>  1176
<211>  42
<212>  PRT
<213>  Homo Sapiens

<400>  1176

Met Pro Gly Arg Ser Cys Val Ala Leu Val Leu Leu Ala Ala Ala Val 
1               5                   10                  15      


Ser Cys Ala Val Ala Gln His Ala Pro Pro Trp Thr Glu Asp Cys Arg 
            20                  25                  30          


Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr 
        35                  40          


<210>  1177
<211>  56
<212>  PRT
<213>  Homo Sapiens

<400>  1177

Met Pro Gly Arg Ser Cys Val Ala Leu Val Leu Leu Ala Ala Ala Val 
1               5                   10                  15      


Ser Cys Ala Val Ala Gln His Ala Pro Pro Trp Thr Glu Asp Cys Arg 
            20                  25                  30          


Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr Leu Ala Tyr Leu Ala Thr 
        35                  40                  45              


Phe Leu Ala Leu Leu Lys Arg Lys 
    50                  55      


<210>  1178
<211>  184
<212>  PRT
<213>  Homo Sapiens

<400>  1178

Met Pro Gly Arg Ser Cys Val Ala Leu Val Leu Leu Ala Ala Ala Val 
1               5                   10                  15      


Ser Cys Ala Val Ala Gln His Ala Pro Pro Trp Thr Glu Asp Cys Arg 
            20                  25                  30          


Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr Val Phe Pro Ala Val Ile 
        35                  40                  45              


Arg Tyr Arg Gly Ala Val Pro Trp Tyr Thr Ile Asn Leu Asp Leu Pro 
    50                  55                  60                  


Pro Tyr Lys Arg Trp His Glu Leu Met Leu Asp Lys Ala Pro Val Leu 
65                  70                  75                  80  


Lys Val Ile Val Asn Ser Leu Lys Asn Met Ile Asn Thr Phe Val Pro 
                85                  90                  95      


Ser Gly Lys Ile Met Gln Val Val Asp Glu Lys Leu Pro Gly Leu Leu 
            100                 105                 110         


Gly Asn Phe Pro Gly Pro Phe Glu Glu Glu Met Lys Gly Ile Ala Ala 
        115                 120                 125             


Val Thr Asp Ile Pro Leu Gly Glu Ile Ile Ser Phe Asn Ile Phe Tyr 
    130                 135                 140                 


Glu Leu Phe Thr Ile Cys Thr Ser Ile Val Ala Glu Asp Lys Lys Gly 
145                 150                 155                 160 


His Leu Ile His Gly Arg Asn Met Asp Phe Gly Val Phe Leu Gly Trp 
                165                 170                 175     


Asn Ile Asn Asn Asp Thr Trp Val 
            180                 


<210>  1179
<211>  62
<212>  PRT
<213>  Homo Sapiens

<400>  1179

Met Pro Gly Arg Ser Cys Val Ala Leu Val Leu Leu Ala Ala Ala Val 
1               5                   10                  15      


Ser Cys Ala Val Ala Gln His Ala Pro Pro Trp Thr Glu Asp Cys Arg 
            20                  25                  30          


Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr Tyr Arg Gly Ala Val Pro 
        35                  40                  45              


Trp Tyr Thr Ile Asn Leu Asp Leu Pro Pro Tyr Lys Arg Cys 
    50                  55                  60          


<210>  1180
<211>  185
<212>  PRT
<213>  Homo Sapiens

<400>  1180

Met Pro Gly Arg Ser Cys Val Ala Leu Val Leu Leu Ala Ala Ala Val 
1               5                   10                  15      


Ser Cys Ala Val Ala Gln His Ala Pro Pro Trp Thr Glu Asp Cys Arg 
            20                  25                  30          


Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr Tyr Arg Gly Ala Val Pro 
        35                  40                  45              


Trp Tyr Thr Ile Asn Leu Asp Leu Pro Pro Tyr Lys Arg Trp His Glu 
    50                  55                  60                  


Leu Met Leu Asp Lys Ala Pro Val Leu Lys Val Ile Val Asn Ser Leu 
65                  70                  75                  80  


Lys Asn Met Ile Asn Thr Phe Val Pro Ser Gly Lys Ile Met Gln Val 
                85                  90                  95      


Val Asp Glu Lys Leu Pro Gly Leu Leu Gly Asn Phe Pro Gly Pro Phe 
            100                 105                 110         


Glu Glu Glu Met Lys Gly Glu Ile Ile Ser Phe Asn Ile Phe Tyr Glu 
        115                 120                 125             


Leu Phe Thr Ile Cys Thr Ser Ile Val Ala Glu Asp Lys Lys Gly His 
    130                 135                 140                 


Leu Ile His Gly Arg Asn Met Asp Phe Gly Val Phe Leu Gly Trp Asn 
145                 150                 155                 160 


Ile Asn Asn Asp Thr Trp Val Ile Thr Glu Gln Leu Lys Pro Leu Thr 
                165                 170                 175     


Val Asn Leu Asp Phe Gln Arg Asn Asn 
            180                 185 


<210>  1181
<211>  375
<212>  PRT
<213>  Homo Sapiens

<400>  1181

Met Pro Gly Arg Ser Cys Val Ala Leu Val Leu Leu Ala Ala Ala Val 
1               5                   10                  15      


Ser Cys Ala Val Ala Gln His Ala Pro Pro Trp Thr Glu Asp Cys Arg 
            20                  25                  30          


Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr Tyr Arg Gly Ala Val Pro 
        35                  40                  45              


Trp Tyr Thr Ile Asn Leu Asp Leu Pro Pro Tyr Lys Arg Trp His Glu 
    50                  55                  60                  


Leu Met Leu Asp Lys Ala Pro Val Leu Lys Val Ile Val Asn Ser Leu 
65                  70                  75                  80  


Lys Asn Met Ile Asn Thr Phe Val Pro Ser Gly Lys Ile Met Gln Val 
                85                  90                  95      


Val Asp Glu Lys Leu Pro Gly Leu Leu Gly Asn Phe Pro Gly Pro Phe 
            100                 105                 110         


Glu Glu Glu Met Lys Gly Ile Ala Ala Val Thr Asp Ile Pro Leu Ala 
        115                 120                 125             


Glu Asp Lys Lys Gly His Leu Ile His Gly Arg Asn Met Asp Phe Gly 
    130                 135                 140                 


Val Phe Leu Gly Trp Asn Ile Asn Asn Asp Thr Trp Val Ile Thr Glu 
145                 150                 155                 160 


Gln Leu Lys Pro Leu Thr Val Asn Leu Asp Phe Gln Arg Asn Asn Lys 
                165                 170                 175     


Thr Val Phe Lys Ala Ser Ser Phe Ala Gly Tyr Val Gly Met Leu Thr 
            180                 185                 190         


Gly Phe Lys Pro Gly Leu Phe Ser Leu Thr Leu Asn Glu Arg Phe Ser 
        195                 200                 205             


Ile Asn Gly Gly Tyr Leu Gly Ile Leu Glu Trp Ile Leu Gly Lys Lys 
    210                 215                 220                 


Asp Val Met Trp Ile Gly Phe Leu Thr Arg Thr Val Leu Glu Asn Ser 
225                 230                 235                 240 


Thr Ser Tyr Glu Glu Ala Lys Asn Leu Leu Thr Lys Thr Lys Ile Leu 
                245                 250                 255     


Ala Pro Ala Tyr Phe Ile Leu Gly Gly Asn Gln Ser Gly Glu Gly Cys 
            260                 265                 270         


Val Ile Thr Arg Asp Arg Lys Glu Ser Leu Asp Val Tyr Glu Leu Asp 
        275                 280                 285             


Ala Lys Gln Gly Arg Trp Tyr Val Val Gln Thr Asn Tyr Asp Arg Trp 
    290                 295                 300                 


Lys His Pro Phe Phe Leu Asp Asp Arg Arg Thr Pro Ala Lys Met Cys 
305                 310                 315                 320 


Leu Asn Arg Thr Ser Gln Glu Asn Ile Ser Phe Glu Thr Met Tyr Asp 
                325                 330                 335     


Val Leu Ser Thr Lys Pro Val Leu Asn Lys Leu Thr Val Tyr Thr Thr 
            340                 345                 350         


Leu Ile Asp Val Thr Lys Gly Gln Phe Glu Thr Tyr Leu Arg Asp Cys 
        355                 360                 365             


Pro Asp Pro Cys Ile Gly Trp 
    370                 375 


<210>  1182
<211>  374
<212>  PRT
<213>  Homo Sapiens

<400>  1182

Met Pro Gly Arg Ser Cys Val Ala Leu Val Leu Leu Ala Ala Ala Val 
1               5                   10                  15      


Ser Cys Ala Val Ala Gln His Ala Pro Pro Trp Thr Glu Asp Cys Arg 
            20                  25                  30          


Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr Tyr Arg Gly Ala Val Pro 
        35                  40                  45              


Trp Tyr Thr Ile Asn Leu Asp Leu Pro Pro Tyr Lys Arg Trp His Glu 
    50                  55                  60                  


Leu Met Leu Asp Lys Ala Pro Val Leu Lys Val Ile Val Asn Ser Leu 
65                  70                  75                  80  


Lys Asn Met Ile Asn Thr Phe Val Pro Ser Gly Lys Ile Met Gln Val 
                85                  90                  95      


Val Asp Glu Lys Leu Pro Gly Leu Leu Gly Asn Phe Pro Gly Pro Phe 
            100                 105                 110         


Glu Glu Glu Met Lys Gly Ile Ala Ala Val Thr Asp Ile Pro Leu Glu 
        115                 120                 125             


Asp Lys Lys Gly His Leu Ile His Gly Arg Asn Met Asp Phe Gly Val 
    130                 135                 140                 


Phe Leu Gly Trp Asn Ile Asn Asn Asp Thr Trp Val Ile Thr Glu Gln 
145                 150                 155                 160 


Leu Lys Pro Leu Thr Val Asn Leu Asp Phe Gln Arg Asn Asn Lys Thr 
                165                 170                 175     


Val Phe Lys Ala Ser Ser Phe Ala Gly Tyr Val Gly Met Leu Thr Gly 
            180                 185                 190         


Phe Lys Pro Gly Leu Phe Ser Leu Thr Leu Asn Glu Arg Phe Ser Ile 
        195                 200                 205             


Asn Gly Gly Tyr Leu Gly Ile Leu Glu Trp Ile Leu Gly Lys Lys Asp 
    210                 215                 220                 


Val Met Trp Ile Gly Phe Leu Thr Arg Thr Val Leu Glu Asn Ser Thr 
225                 230                 235                 240 


Ser Tyr Glu Glu Ala Lys Asn Leu Leu Thr Lys Thr Lys Ile Leu Ala 
                245                 250                 255     


Pro Ala Tyr Phe Ile Leu Gly Gly Asn Gln Ser Gly Glu Gly Cys Val 
            260                 265                 270         


Ile Thr Arg Asp Arg Lys Glu Ser Leu Asp Val Tyr Glu Leu Asp Ala 
        275                 280                 285             


Lys Gln Gly Arg Trp Tyr Val Val Gln Thr Asn Tyr Asp Arg Trp Lys 
    290                 295                 300                 


His Pro Phe Phe Leu Asp Asp Arg Arg Thr Pro Ala Lys Met Cys Leu 
305                 310                 315                 320 


Asn Arg Thr Ser Gln Glu Asn Ile Ser Phe Glu Thr Met Tyr Asp Val 
                325                 330                 335     


Leu Ser Thr Lys Pro Val Leu Asn Lys Leu Thr Val Tyr Thr Thr Leu 
            340                 345                 350         


Ile Asp Val Thr Lys Gly Gln Phe Glu Thr Tyr Leu Arg Asp Cys Pro 
        355                 360                 365             


Asp Pro Cys Ile Gly Trp 
    370                 


<210>  1183
<211>  395
<212>  PRT
<213>  Homo Sapiens

<400>  1183

Met Pro Gly Arg Ser Cys Val Ala Leu Val Leu Leu Ala Ala Ala Val 
1               5                   10                  15      


Ser Cys Ala Val Ala Gln His Ala Pro Pro Trp Thr Glu Asp Cys Arg 
            20                  25                  30          


Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr Tyr Arg Gly Ala Val Pro 
        35                  40                  45              


Trp Tyr Thr Ile Asn Leu Asp Leu Pro Pro Tyr Lys Arg Trp His Glu 
    50                  55                  60                  


Leu Met Leu Asp Lys Ala Pro Val Leu Lys Val Ile Val Asn Ser Leu 
65                  70                  75                  80  


Lys Asn Met Ile Asn Thr Phe Val Pro Ser Gly Lys Ile Met Gln Val 
                85                  90                  95      


Val Asp Glu Lys Leu Pro Gly Leu Leu Gly Asn Phe Pro Gly Pro Phe 
            100                 105                 110         


Glu Glu Glu Met Lys Gly Ile Ala Ala Val Thr Asp Ile Pro Leu Gly 
        115                 120                 125             


Glu Ile Ile Ser Phe Asn Ile Phe Tyr Glu Leu Phe Thr Ile Cys Thr 
    130                 135                 140                 


Ser Ile Val Ala Glu Asp Lys Lys Gly His Leu Ile His Gly Arg Asn 
145                 150                 155                 160 


Met Asp Phe Gly Val Phe Leu Gly Trp Asn Ile Asn Asn Asp Thr Trp 
                165                 170                 175     


Val Ile Thr Glu Gln Leu Lys Pro Leu Thr Val Asn Leu Asp Phe Gln 
            180                 185                 190         


Arg Asn Asn Lys Thr Val Phe Lys Ala Ser Ser Phe Ala Gly Tyr Val 
        195                 200                 205             


Gly Met Leu Thr Gly Phe Lys Pro Gly Leu Phe Ser Leu Thr Leu Asn 
    210                 215                 220                 


Glu Arg Phe Ser Ile Asn Gly Gly Tyr Leu Gly Ile Leu Glu Trp Ile 
225                 230                 235                 240 


Leu Gly Lys Lys Asp Val Met Trp Ile Gly Phe Leu Thr Arg Thr Val 
                245                 250                 255     


Leu Glu Asn Ser Thr Ser Tyr Glu Glu Ala Lys Asn Leu Leu Thr Lys 
            260                 265                 270         


Thr Lys Ile Leu Ala Pro Ala Tyr Phe Ile Leu Gly Gly Asn Gln Ser 
        275                 280                 285             


Gly Glu Gly Cys Val Ile Thr Arg Asp Arg Lys Glu Ser Leu Asp Val 
    290                 295                 300                 


Tyr Glu Leu Asp Ala Lys Gln Gly Arg Trp Tyr Val Val Gln Thr Asn 
305                 310                 315                 320 


Tyr Asp Arg Trp Lys His Pro Phe Phe Leu Asp Asp Arg Arg Thr Pro 
                325                 330                 335     


Ala Lys Met Cys Leu Asn Arg Thr Ser Gln Glu Asn Ile Ser Phe Glu 
            340                 345                 350         


Thr Met Tyr Asp Val Leu Ser Thr Lys Pro Val Leu Asn Lys Leu Thr 
        355                 360                 365             


Val Tyr Thr Thr Leu Ile Asp Val Thr Lys Gly Gln Phe Glu Thr Tyr 
    370                 375                 380                 


Leu Arg Asp Cys Pro Asp Pro Cys Ile Gly Trp 
385                 390                 395 


<210>  1184
<211>  395
<212>  PRT
<213>  Homo Sapiens

<400>  1184

Met Pro Gly Arg Ser Cys Val Ala Leu Val Leu Leu Ala Ala Ala Val 
1               5                   10                  15      


Ser Cys Ala Val Ala Gln His Ala Pro Pro Trp Thr Glu Asp Cys Arg 
            20                  25                  30          


Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr Tyr Arg Gly Ala Val Pro 
        35                  40                  45              


Trp Tyr Thr Ile Asn Leu Asp Leu Pro Pro Tyr Lys Arg Trp His Glu 
    50                  55                  60                  


Leu Met Leu Asp Lys Ala Pro Val Leu Lys Val Ile Val Asn Ser Leu 
65                  70                  75                  80  


Lys Asn Met Ile Asn Thr Phe Val Pro Ser Gly Lys Ile Met Gln Val 
                85                  90                  95      


Val Asp Glu Lys Leu Pro Gly Leu Leu Gly Asn Phe Pro Gly Pro Phe 
            100                 105                 110         


Glu Glu Glu Met Lys Gly Ile Ala Ala Val Thr Asp Ile Pro Leu Gly 
        115                 120                 125             


Glu Ile Ile Ser Phe Asn Ile Phe Tyr Glu Leu Phe Thr Ile Cys Thr 
    130                 135                 140                 


Ser Ile Val Ala Glu Asp Lys Lys Gly His Leu Ile His Gly Arg Asn 
145                 150                 155                 160 


Met Asp Phe Gly Val Phe Leu Gly Trp Asn Ile Asn Asn Asp Thr Trp 
                165                 170                 175     


Val Ile Thr Glu Gln Leu Lys Pro Leu Thr Val Asn Leu Asp Phe Gln 
            180                 185                 190         


Arg Asn Asn Lys Thr Val Phe Lys Ala Ser Ser Phe Ala Gly Tyr Val 
        195                 200                 205             


Gly Met Leu Thr Gly Phe Lys Pro Gly Leu Phe Ser Leu Thr Leu Asn 
    210                 215                 220                 


Glu Arg Phe Ser Ile Asn Gly Gly Tyr Leu Gly Ile Leu Glu Trp Ile 
225                 230                 235                 240 


Leu Gly Lys Lys Asp Val Met Trp Ile Gly Phe Leu Thr Arg Thr Val 
                245                 250                 255     


Leu Glu Asn Ser Thr Ser Tyr Glu Glu Ala Lys Asn Leu Leu Thr Lys 
            260                 265                 270         


Thr Lys Ile Leu Ala Pro Ala Tyr Phe Ile Leu Gly Gly Asn Gln Ser 
        275                 280                 285             


Gly Glu Gly Cys Val Ile Thr Arg Asp Arg Lys Glu Ser Leu Asp Val 
    290                 295                 300                 


Tyr Glu Leu Asp Ala Lys Gln Gly Arg Trp Tyr Val Val Gln Thr Asn 
305                 310                 315                 320 


Tyr Asp Arg Trp Lys His Pro Phe Phe Leu Asp Asp Arg Arg Thr Pro 
                325                 330                 335     


Ala Lys Met Cys Leu Asn Arg Thr Ser Gln Glu Asn Ile Ser Phe Glu 
            340                 345                 350         


Thr Met Tyr Asp Val Leu Ser Thr Lys Pro Val Leu Asn Lys Leu Thr 
        355                 360                 365             


Val Tyr Thr Thr Leu Ile Asp Val Thr Lys Gly Gln Phe Glu Thr Tyr 
    370                 375                 380                 


Leu Arg Asp Cys Pro Asp Pro Cys Ile Gly Trp 
385                 390                 395 


<210>  1185
<211>  395
<212>  PRT
<213>  Homo Sapiens

<400>  1185

Met Pro Gly Arg Ser Cys Val Ala Leu Val Leu Leu Ala Ala Ala Val 
1               5                   10                  15      


Ser Cys Ala Val Ala Gln His Ala Pro Pro Trp Thr Glu Asp Cys Arg 
            20                  25                  30          


Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr Tyr Arg Gly Ala Val Pro 
        35                  40                  45              


Trp Tyr Thr Ile Asn Leu Asp Leu Pro Pro Tyr Lys Arg Trp His Glu 
    50                  55                  60                  


Leu Met Leu Asp Lys Ala Pro Val Leu Lys Val Ile Val Asn Ser Leu 
65                  70                  75                  80  


Lys Asn Met Ile Asn Thr Phe Val Pro Ser Gly Lys Ile Met Gln Val 
                85                  90                  95      


Val Asp Glu Lys Leu Pro Gly Leu Leu Gly Asn Phe Pro Gly Pro Phe 
            100                 105                 110         


Glu Glu Glu Met Lys Gly Ile Ala Ala Val Thr Asp Ile Pro Leu Gly 
        115                 120                 125             


Glu Ile Ile Ser Phe Asn Ile Phe Tyr Glu Leu Phe Thr Ile Cys Thr 
    130                 135                 140                 


Ser Ile Val Ala Glu Asp Lys Lys Gly His Leu Ile His Gly Arg Asn 
145                 150                 155                 160 


Met Asp Phe Gly Val Phe Leu Gly Trp Asn Ile Asn Asn Asp Thr Trp 
                165                 170                 175     


Val Ile Thr Glu Gln Leu Lys Pro Leu Thr Val Asn Leu Asp Phe Gln 
            180                 185                 190         


Arg Asn Asn Lys Thr Val Phe Lys Ala Ser Ser Phe Ala Gly Tyr Val 
        195                 200                 205             


Gly Met Leu Thr Gly Phe Lys Pro Gly Leu Phe Ser Leu Thr Leu Asn 
    210                 215                 220                 


Glu Arg Phe Ser Ile Asn Gly Gly Tyr Leu Gly Ile Leu Glu Trp Ile 
225                 230                 235                 240 


Leu Gly Lys Lys Asp Val Met Trp Ile Gly Phe Leu Thr Arg Thr Val 
                245                 250                 255     


Leu Glu Asn Ser Thr Ser Tyr Glu Glu Ala Lys Asn Leu Leu Thr Lys 
            260                 265                 270         


Thr Lys Ile Leu Ala Pro Ala Tyr Phe Ile Leu Gly Gly Asn Gln Ser 
        275                 280                 285             


Gly Glu Gly Cys Val Ile Thr Arg Asp Arg Lys Glu Ser Leu Asp Val 
    290                 295                 300                 


Tyr Glu Leu Asp Ala Lys Gln Gly Arg Trp Tyr Val Val Gln Thr Asn 
305                 310                 315                 320 


Tyr Asp Arg Trp Lys His Pro Phe Phe Leu Asp Asp Arg Arg Thr Pro 
                325                 330                 335     


Ala Lys Met Cys Leu Asn Arg Thr Ser Gln Glu Asn Ile Ser Phe Glu 
            340                 345                 350         


Thr Met Tyr Asp Val Leu Ser Thr Lys Pro Val Leu Asn Lys Leu Thr 
        355                 360                 365             


Val Tyr Thr Thr Leu Ile Asp Val Thr Lys Gly Gln Phe Glu Thr Tyr 
    370                 375                 380                 


Leu Arg Asp Cys Pro Asp Pro Cys Ile Gly Trp 
385                 390                 395 


<210>  1186
<211>  173
<212>  PRT
<213>  Homo Sapiens

<400>  1186

Met Pro Gly Arg Ser Cys Val Ala Leu Val Leu Leu Ala Ala Ala Val 
1               5                   10                  15      


Ser Cys Ala Val Ala Gln His Ala Pro Pro Trp Thr Glu Asp Cys Arg 
            20                  25                  30          


Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr Tyr Arg Gly Ala Val Pro 
        35                  40                  45              


Trp Tyr Thr Ile Asn Leu Asp Leu Pro Pro Tyr Lys Arg Trp His Glu 
    50                  55                  60                  


Leu Met Leu Asp Lys Ala Pro Val Leu Lys Val Ile Val Asn Ser Leu 
65                  70                  75                  80  


Lys Asn Met Ile Asn Thr Phe Val Pro Ser Gly Lys Ile Met Gln Val 
                85                  90                  95      


Val Asp Glu Lys Leu Pro Gly Leu Leu Gly Asn Phe Pro Gly Pro Phe 
            100                 105                 110         


Glu Glu Glu Met Lys Gly Ile Ala Ala Val Thr Asp Ile Pro Leu Gly 
        115                 120                 125             


Glu Ile Ile Ser Phe Asn Ile Phe Tyr Glu Leu Phe Thr Ile Cys Thr 
    130                 135                 140                 


Ser Ile Val Ala Glu Asp Lys Lys Gly Asn Cys Ala Leu Arg Glu Gly 
145                 150                 155                 160 


Gly Gln His Glu Ala Leu His Lys Glu Lys Ser Ser Lys 
                165                 170             


<210>  1187
<211>  370
<212>  PRT
<213>  Homo Sapiens

<400>  1187

Met Pro Gly Arg Ser Cys Val Ala Leu Val Leu Leu Ala Ala Ala Val 
1               5                   10                  15      


Ser Cys Ala Val Ala Gln His Ala Pro Pro Trp Thr Glu Asp Cys Arg 
            20                  25                  30          


Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr Tyr Arg Gly Ala Val Pro 
        35                  40                  45              


Trp Tyr Thr Ile Asn Leu Asp Leu Pro Pro Tyr Lys Arg Trp His Glu 
    50                  55                  60                  


Leu Met Leu Asp Lys Ala Pro Val Leu Lys Val Ile Val Asn Ser Leu 
65                  70                  75                  80  


Lys Asn Met Ile Asn Thr Phe Val Pro Ser Gly Lys Ile Met Gln Val 
                85                  90                  95      


Val Asp Glu Lys Leu Pro Gly Leu Leu Gly Asn Phe Pro Gly Pro Phe 
            100                 105                 110         


Glu Glu Glu Met Lys Gly Ile Ala Ala Val Thr Asp Ile Pro Leu Gly 
        115                 120                 125             


His Leu Ile His Gly Arg Asn Met Asp Phe Gly Val Phe Leu Gly Trp 
    130                 135                 140                 


Asn Ile Asn Asn Asp Thr Trp Val Ile Thr Glu Gln Leu Lys Pro Leu 
145                 150                 155                 160 


Thr Val Asn Leu Asp Phe Gln Arg Asn Asn Lys Thr Val Phe Lys Ala 
                165                 170                 175     


Ser Ser Phe Ala Gly Tyr Val Gly Met Leu Thr Gly Phe Lys Pro Gly 
            180                 185                 190         


Leu Phe Ser Leu Thr Leu Asn Glu Arg Phe Ser Ile Asn Gly Gly Tyr 
        195                 200                 205             


Leu Gly Ile Leu Glu Trp Ile Leu Gly Lys Lys Asp Val Met Trp Ile 
    210                 215                 220                 


Gly Phe Leu Thr Arg Thr Val Leu Glu Asn Ser Thr Ser Tyr Glu Glu 
225                 230                 235                 240 


Ala Lys Asn Leu Leu Thr Lys Thr Lys Ile Leu Ala Pro Ala Tyr Phe 
                245                 250                 255     


Ile Leu Gly Gly Asn Gln Ser Gly Glu Gly Cys Val Ile Thr Arg Asp 
            260                 265                 270         


Arg Lys Glu Ser Leu Asp Val Tyr Glu Leu Asp Ala Lys Gln Gly Arg 
        275                 280                 285             


Trp Tyr Val Val Gln Thr Asn Tyr Asp Arg Trp Lys His Pro Phe Phe 
    290                 295                 300                 


Leu Asp Asp Arg Arg Thr Pro Ala Lys Met Cys Leu Asn Arg Thr Ser 
305                 310                 315                 320 


Gln Glu Asn Ile Ser Phe Glu Thr Met Tyr Asp Val Leu Ser Thr Lys 
                325                 330                 335     


Pro Val Leu Asn Lys Leu Thr Val Tyr Thr Thr Leu Ile Asp Val Thr 
            340                 345                 350         


Lys Gly Gln Phe Glu Thr Tyr Leu Arg Asp Cys Pro Asp Pro Cys Ile 
        355                 360                 365             


Gly Trp 
    370 


<210>  1188
<211>  288
<212>  PRT
<213>  Homo Sapiens

<400>  1188

Met Pro Gly Arg Ser Cys Val Ala Leu Val Leu Leu Ala Ala Ala Val 
1               5                   10                  15      


Ser Cys Ala Val Ala Gln His Ala Pro Pro Trp Thr Glu Asp Cys Arg 
            20                  25                  30          


Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr Tyr Arg Gly Ala Val Pro 
        35                  40                  45              


Trp Tyr Thr Ile Asn Leu Asp Leu Pro Pro Tyr Lys Arg Trp His Glu 
    50                  55                  60                  


Leu Met Leu Asp Lys Ala Pro Val Leu Lys Val Ile Val Asn Ser Leu 
65                  70                  75                  80  


Lys Asn Met Ile Asn Thr Phe Val Pro Ser Gly Lys Ile Met Gln Val 
                85                  90                  95      


Val Asp Glu Lys Leu Pro Gly Leu Leu Gly Asn Phe Pro Gly Pro Phe 
            100                 105                 110         


Glu Glu Glu Met Lys Gly Ile Ala Ala Val Thr Asp Ile Pro Leu Gly 
        115                 120                 125             


Ile Leu Glu Trp Ile Leu Gly Lys Lys Asp Val Met Trp Ile Gly Phe 
    130                 135                 140                 


Leu Thr Arg Thr Val Leu Glu Asn Ser Thr Ser Tyr Glu Glu Ala Lys 
145                 150                 155                 160 


Asn Leu Leu Thr Lys Thr Lys Ile Leu Ala Pro Ala Tyr Phe Ile Leu 
                165                 170                 175     


Gly Gly Asn Gln Ser Gly Glu Gly Cys Val Ile Thr Arg Asp Arg Lys 
            180                 185                 190         


Glu Ser Leu Asp Val Tyr Glu Leu Asp Ala Lys Gln Gly Arg Trp Tyr 
        195                 200                 205             


Val Val Gln Thr Asn Tyr Asp Arg Trp Lys His Pro Phe Phe Leu Asp 
    210                 215                 220                 


Asp Arg Arg Thr Pro Ala Lys Met Cys Leu Asn Arg Thr Ser Gln Glu 
225                 230                 235                 240 


Asn Ile Ser Phe Glu Thr Met Tyr Asp Val Leu Ser Thr Lys Pro Val 
                245                 250                 255     


Leu Asn Lys Leu Thr Val Tyr Thr Thr Leu Ile Asp Val Thr Lys Gly 
            260                 265                 270         


Gln Phe Glu Thr Tyr Leu Arg Asp Cys Pro Asp Pro Cys Ile Gly Trp 
        275                 280                 285             


<210>  1189
<211>  175
<212>  PRT
<213>  Homo Sapiens

<400>  1189

Met Pro Gly Arg Ser Cys Val Ala Leu Val Leu Leu Ala Ala Ala Val 
1               5                   10                  15      


Ser Cys Ala Val Ala Gln His Ala Pro Pro Trp Thr Glu Asp Cys Arg 
            20                  25                  30          


Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr Tyr Arg Gly Ala Val Pro 
        35                  40                  45              


Trp Tyr Thr Ile Asn Leu Asp Leu Pro Pro Tyr Lys Arg Trp His Glu 
    50                  55                  60                  


Leu Met Leu Asp Lys Ala Pro Val Leu Lys Val Ile Val Asn Ser Leu 
65                  70                  75                  80  


Lys Asn Met Ile Asn Thr Phe Val Pro Ser Gly Lys Ile Met Gln Val 
                85                  90                  95      


Val Asp Glu Lys Leu Pro Gly Leu Leu Gly Asn Phe Pro Gly Pro Phe 
            100                 105                 110         


Glu Glu Glu Met Lys Gly Ile Ala Ala Val Thr Asp Ile Pro Leu Gly 
        115                 120                 125             


Lys Val His Leu Glu Ala Leu Lys Lys Lys Val Ile Lys Phe Phe Tyr 
    130                 135                 140                 


Lys Phe Pro Leu Arg Cys Asp Ile His Thr Ala Gln Val Leu Tyr Val 
145                 150                 155                 160 


Leu Asp Ile Gln His Arg Cys Thr Gly Leu Arg Tyr Thr Ala Gln 
                165                 170                 175 


<210>  1190
<211>  376
<212>  PRT
<213>  Homo Sapiens

<400>  1190

Met Pro Gly Arg Ser Cys Val Ala Leu Val Leu Leu Ala Ala Ala Val 
1               5                   10                  15      


Ser Cys Ala Val Ala Gln His Ala Pro Pro Trp Thr Glu Asp Cys Arg 
            20                  25                  30          


Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr Tyr Arg Gly Ala Val Pro 
        35                  40                  45              


Trp Tyr Thr Ile Asn Leu Asp Leu Pro Pro Tyr Lys Arg Trp His Glu 
    50                  55                  60                  


Leu Met Leu Asp Lys Ala Pro Val Leu Lys Val Ile Val Asn Ser Leu 
65                  70                  75                  80  


Lys Asn Met Ile Asn Thr Phe Val Pro Ser Gly Lys Ile Met Gln Val 
                85                  90                  95      


Val Asp Glu Lys Leu Pro Gly Leu Leu Gly Asn Phe Pro Gly Pro Phe 
            100                 105                 110         


Glu Glu Glu Met Lys Gly Ile Ala Ala Val Thr Asp Ile Pro Leu Val 
        115                 120                 125             


Ala Glu Asp Lys Lys Gly His Leu Ile His Gly Arg Asn Met Asp Phe 
    130                 135                 140                 


Gly Val Phe Leu Gly Trp Asn Ile Asn Asn Asp Thr Trp Val Ile Thr 
145                 150                 155                 160 


Glu Gln Leu Lys Pro Leu Thr Val Asn Leu Asp Phe Gln Arg Asn Asn 
                165                 170                 175     


Lys Thr Val Phe Lys Ala Ser Ser Phe Ala Gly Tyr Val Gly Met Leu 
            180                 185                 190         


Thr Gly Phe Lys Pro Gly Leu Phe Ser Leu Thr Leu Asn Glu Arg Phe 
        195                 200                 205             


Ser Ile Asn Gly Gly Tyr Leu Gly Ile Leu Glu Trp Ile Leu Gly Lys 
    210                 215                 220                 


Lys Asp Val Met Trp Ile Gly Phe Leu Thr Arg Thr Val Leu Glu Asn 
225                 230                 235                 240 


Ser Thr Ser Tyr Glu Glu Ala Lys Asn Leu Leu Thr Lys Thr Lys Ile 
                245                 250                 255     


Leu Ala Pro Ala Tyr Phe Ile Leu Gly Gly Asn Gln Ser Gly Glu Gly 
            260                 265                 270         


Cys Val Ile Thr Arg Asp Arg Lys Glu Ser Leu Asp Val Tyr Glu Leu 
        275                 280                 285             


Asp Ala Lys Gln Gly Arg Trp Tyr Val Val Gln Thr Asn Tyr Asp Arg 
    290                 295                 300                 


Trp Lys His Pro Phe Phe Leu Asp Asp Arg Arg Thr Pro Ala Lys Met 
305                 310                 315                 320 


Cys Leu Asn Arg Thr Ser Gln Glu Asn Ile Ser Phe Glu Thr Met Tyr 
                325                 330                 335     


Asp Val Leu Ser Thr Lys Pro Val Leu Asn Lys Leu Thr Val Tyr Thr 
            340                 345                 350         


Thr Leu Ile Asp Val Thr Lys Gly Gln Phe Glu Thr Tyr Leu Arg Asp 
        355                 360                 365             


Cys Pro Asp Pro Cys Ile Gly Trp 
    370                 375     


<210>  1191
<211>  246
<212>  PRT
<213>  Homo Sapiens

<400>  1191

Met Pro Gly Arg Ser Cys Val Ala Leu Val Leu Leu Ala Ala Ala Val 
1               5                   10                  15      


Ser Cys Ala Val Ala Gln His Ala Pro Pro Trp Thr Glu Asp Cys Arg 
            20                  25                  30          


Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr Tyr Arg Gly Ala Val Pro 
        35                  40                  45              


Trp Tyr Thr Ile Asn Leu Asp Leu Pro Pro Tyr Lys Arg Trp His Glu 
    50                  55                  60                  


Leu Met Leu Asp Lys Ala Pro Val Leu Lys Val Ile Val Asn Ser Leu 
65                  70                  75                  80  


Lys Asn Met Ile Asn Thr Phe Val Pro Ser Gly Lys Ile Met Gln Val 
                85                  90                  95      


Val Asp Glu Lys Leu Pro Gly Leu Leu Gly Asn Phe Pro Gly Pro Phe 
            100                 105                 110         


Glu Glu Glu Met Lys Gly Ile Ala Ala Val Thr Asp Ile Pro Leu Val 
        115                 120                 125             


Asn Leu Asp Phe Gln Arg Asn Asn Lys Thr Val Phe Lys Ala Ser Ser 
    130                 135                 140                 


Phe Ala Gly Tyr Val Gly Met Leu Thr Gly Phe Lys Pro Gly Leu Phe 
145                 150                 155                 160 


Ser Leu Thr Leu Asn Glu Arg Phe Ser Ile Asn Gly Gly Tyr Leu Gly 
                165                 170                 175     


Ile Leu Glu Trp Ile Leu Gly Lys Lys Asp Val Met Trp Ile Gly Phe 
            180                 185                 190         


Leu Thr Arg Thr Val Leu Glu Asn Ser Thr Ser Tyr Glu Glu Ala Lys 
        195                 200                 205             


Asn Leu Leu Thr Lys Thr Lys Ile Leu Ala Pro Ala Tyr Phe Ile Leu 
    210                 215                 220                 


Gly Gly Asn Gln Ser Gly Glu Gly Cys Val Ile Thr Arg Asp Arg Lys 
225                 230                 235                 240 


Glu Ser Leu Asp Val Tyr 
                245     


<210>  1192
<211>  366
<212>  PRT
<213>  Homo Sapiens

<400>  1192

Met Pro Gly Arg Ser Cys Val Ala Leu Val Leu Leu Ala Ala Ala Val 
1               5                   10                  15      


Ser Cys Ala Val Ala Gln His Ala Pro Pro Trp Thr Glu Asp Cys Arg 
            20                  25                  30          


Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr Tyr Arg Gly Ala Val Pro 
        35                  40                  45              


Trp Tyr Thr Ile Asn Leu Asp Leu Pro Pro Tyr Lys Arg Trp His Glu 
    50                  55                  60                  


Leu Met Leu Asp Lys Ala Pro Val Pro Gly Leu Leu Gly Asn Phe Pro 
65                  70                  75                  80  


Gly Pro Phe Glu Glu Glu Met Lys Gly Ile Ala Ala Val Thr Asp Ile 
                85                  90                  95      


Pro Leu Gly Glu Ile Ile Ser Phe Asn Ile Phe Tyr Glu Leu Phe Thr 
            100                 105                 110         


Ile Cys Thr Ser Ile Val Ala Glu Asp Lys Lys Gly His Leu Ile His 
        115                 120                 125             


Gly Arg Asn Met Asp Phe Gly Val Phe Leu Gly Trp Asn Ile Asn Asn 
    130                 135                 140                 


Asp Thr Trp Val Ile Thr Glu Gln Leu Lys Pro Leu Thr Val Asn Leu 
145                 150                 155                 160 


Asp Phe Gln Arg Asn Asn Lys Thr Val Phe Lys Ala Ser Ser Phe Ala 
                165                 170                 175     


Gly Tyr Val Gly Met Leu Thr Gly Phe Lys Pro Gly Leu Phe Ser Leu 
            180                 185                 190         


Thr Leu Asn Glu Arg Phe Ser Ile Asn Gly Gly Tyr Leu Gly Ile Leu 
        195                 200                 205             


Glu Trp Ile Leu Gly Lys Lys Asp Val Met Trp Ile Gly Phe Leu Thr 
    210                 215                 220                 


Arg Thr Val Leu Glu Asn Ser Thr Ser Tyr Glu Glu Ala Lys Asn Leu 
225                 230                 235                 240 


Leu Thr Lys Thr Lys Ile Leu Ala Pro Ala Tyr Phe Ile Leu Gly Gly 
                245                 250                 255     


Asn Gln Ser Gly Glu Gly Cys Val Ile Thr Arg Asp Arg Lys Glu Ser 
            260                 265                 270         


Leu Asp Val Tyr Glu Leu Asp Ala Lys Gln Gly Arg Trp Tyr Val Val 
        275                 280                 285             


Gln Thr Asn Tyr Asp Arg Trp Lys His Pro Phe Phe Leu Asp Asp Arg 
    290                 295                 300                 


Arg Thr Pro Ala Lys Met Cys Leu Asn Arg Thr Ser Gln Glu Asn Ile 
305                 310                 315                 320 


Ser Phe Glu Thr Met Tyr Asp Val Leu Ser Thr Lys Pro Val Leu Asn 
                325                 330                 335     


Lys Leu Thr Val Tyr Thr Thr Leu Ile Asp Val Thr Lys Gly Gln Phe 
            340                 345                 350         


Glu Thr Tyr Leu Arg Asp Cys Pro Asp Pro Cys Ile Gly Trp 
        355                 360                 365     


<210>  1193
<211>  393
<212>  PRT
<213>  Homo Sapiens

<400>  1193

Met Pro Gly Arg Ser Cys Val Ala Leu Val Leu Leu Ala Ala Ala Val 
1               5                   10                  15      


Ser Cys Ala Val Ala Gln His Ala Pro Pro Trp Thr Glu Asp Cys Arg 
            20                  25                  30          


Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr Tyr Arg Gly Ala Val Pro 
        35                  40                  45              


Trp Tyr Thr Ile Asn Leu Asp Leu Pro Pro Tyr Lys Arg Trp His Glu 
    50                  55                  60                  


Leu Met Leu Asp Lys Ala Pro Val Val Ile Val Asn Ser Leu Lys Asn 
65                  70                  75                  80  


Met Ile Asn Thr Phe Val Pro Ser Gly Lys Ile Met Gln Val Val Asp 
                85                  90                  95      


Glu Lys Leu Pro Gly Leu Leu Gly Asn Phe Pro Gly Pro Phe Glu Glu 
            100                 105                 110         


Glu Met Lys Gly Ile Ala Ala Val Thr Asp Ile Pro Leu Gly Glu Ile 
        115                 120                 125             


Ile Ser Phe Asn Ile Phe Tyr Glu Leu Phe Thr Ile Cys Thr Ser Ile 
    130                 135                 140                 


Val Ala Glu Asp Lys Lys Gly His Leu Ile His Gly Arg Asn Met Asp 
145                 150                 155                 160 


Phe Gly Val Phe Leu Gly Trp Asn Ile Asn Asn Asp Thr Trp Val Ile 
                165                 170                 175     


Thr Glu Gln Leu Lys Pro Leu Thr Val Asn Leu Asp Phe Gln Arg Asn 
            180                 185                 190         


Asn Lys Thr Val Phe Lys Ala Ser Ser Phe Ala Gly Tyr Val Gly Met 
        195                 200                 205             


Leu Thr Gly Phe Lys Pro Gly Leu Phe Ser Leu Thr Leu Asn Glu Arg 
    210                 215                 220                 


Phe Ser Ile Asn Gly Gly Tyr Leu Gly Ile Leu Glu Trp Ile Leu Gly 
225                 230                 235                 240 


Lys Lys Asp Val Met Trp Ile Gly Phe Leu Thr Arg Thr Val Leu Glu 
                245                 250                 255     


Asn Ser Thr Ser Tyr Glu Glu Ala Lys Asn Leu Leu Thr Lys Thr Lys 
            260                 265                 270         


Ile Leu Ala Pro Ala Tyr Phe Ile Leu Gly Gly Asn Gln Ser Gly Glu 
        275                 280                 285             


Gly Cys Val Ile Thr Arg Asp Arg Lys Glu Ser Leu Asp Val Tyr Glu 
    290                 295                 300                 


Leu Asp Ala Lys Gln Gly Arg Trp Tyr Val Val Gln Thr Asn Tyr Asp 
305                 310                 315                 320 


Arg Trp Lys His Pro Phe Phe Leu Asp Asp Arg Arg Thr Pro Ala Lys 
                325                 330                 335     


Met Cys Leu Asn Arg Thr Ser Gln Glu Asn Ile Ser Phe Glu Thr Met 
            340                 345                 350         


Tyr Asp Val Leu Ser Thr Lys Pro Val Leu Asn Lys Leu Thr Val Tyr 
        355                 360                 365             


Thr Thr Leu Ile Asp Val Thr Lys Gly Gln Phe Glu Thr Tyr Leu Arg 
    370                 375                 380                 


Asp Cys Pro Asp Pro Cys Ile Gly Trp 
385                 390             


<210>  1194
<211>  368
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1194

Xaa Leu Ala Ala Ala Val Ser Cys Ala Val Ala Gln His Ala Pro Pro 
1               5                   10                  15      


Val Ser Glu Leu Glu Pro Arg Arg Arg Glu Gly Arg Ala Val Asp Arg 
            20                  25                  30          


Gly Leu Gln Lys Ile Asn Leu Ser Ser Phe Arg Thr Asn Leu Lys Val 
        35                  40                  45              


Ile Val Asn Ser Leu Lys Asn Met Ile Asn Thr Phe Val Pro Ser Gly 
    50                  55                  60                  


Lys Ile Met Gln Val Val Asp Glu Lys Leu Pro Gly Leu Leu Gly Asn 
65                  70                  75                  80  


Phe Pro Gly Pro Phe Glu Glu Glu Met Lys Gly Ile Ala Ala Val Thr 
                85                  90                  95      


Asp Ile Pro Leu Gly Glu Ile Ile Ser Phe Asn Ile Phe Tyr Glu Leu 
            100                 105                 110         


Phe Thr Ile Cys Thr Ser Ile Val Ala Glu Asp Lys Lys Gly His Leu 
        115                 120                 125             


Ile His Gly Arg Asn Met Asp Phe Gly Val Phe Leu Gly Trp Asn Ile 
    130                 135                 140                 


Asn Asn Asp Thr Trp Val Ile Thr Glu Gln Leu Lys Pro Leu Thr Val 
145                 150                 155                 160 


Asn Leu Asp Phe Gln Arg Asn Asn Lys Thr Val Phe Lys Ala Ser Ser 
                165                 170                 175     


Phe Ala Gly Tyr Val Gly Met Leu Thr Gly Phe Lys Pro Gly Leu Phe 
            180                 185                 190         


Ser Leu Thr Leu Asn Glu Arg Phe Ser Ile Asn Gly Gly Tyr Leu Gly 
        195                 200                 205             


Ile Leu Glu Trp Ile Leu Gly Lys Lys Asp Val Met Trp Ile Gly Phe 
    210                 215                 220                 


Leu Thr Arg Thr Val Leu Glu Asn Ser Thr Ser Tyr Glu Glu Ala Lys 
225                 230                 235                 240 


Asn Leu Leu Thr Lys Thr Lys Ile Leu Ala Pro Ala Tyr Phe Ile Leu 
                245                 250                 255     


Gly Gly Asn Gln Ser Gly Glu Gly Cys Val Ile Thr Arg Asp Arg Lys 
            260                 265                 270         


Glu Ser Leu Asp Val Tyr Glu Leu Asp Ala Lys Gln Gly Arg Trp Tyr 
        275                 280                 285             


Val Val Gln Thr Asn Tyr Asp Arg Trp Lys His Pro Phe Phe Leu Asp 
    290                 295                 300                 


Asp Arg Arg Thr Pro Ala Lys Met Cys Leu Asn Arg Thr Ser Gln Glu 
305                 310                 315                 320 


Asn Ile Ser Phe Glu Thr Met Tyr Asp Val Leu Ser Thr Lys Pro Val 
                325                 330                 335     


Leu Asn Lys Leu Thr Val Tyr Thr Thr Leu Ile Asp Val Thr Lys Gly 
            340                 345                 350         


Gln Phe Glu Thr Tyr Leu Arg Asp Cys Pro Asp Pro Cys Ile Gly Trp 
        355                 360                 365             


<210>  1195
<211>  200
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1195

Xaa Asn Asn Lys Thr Val Phe Lys Ala Ser Ser Phe Ala Gly Tyr Val 
1               5                   10                  15      


Gly Met Leu Thr Gly Phe Lys Pro Gly Leu Phe Ser Leu Thr Leu Asn 
            20                  25                  30          


Glu Arg Phe Ser Ile Asn Gly Gly Tyr Leu Glu Trp Ile Leu Gly Lys 
        35                  40                  45              


Lys Asp Val Met Trp Ile Gly Phe Leu Thr Arg Thr Val Leu Glu Asn 
    50                  55                  60                  


Ser Thr Ser Tyr Glu Glu Ala Lys Asn Leu Leu Thr Lys Thr Lys Ile 
65                  70                  75                  80  


Leu Ala Pro Ala Tyr Phe Ile Leu Gly Gly Asn Gln Ser Gly Glu Gly 
                85                  90                  95      


Cys Val Ile Thr Arg Asp Arg Lys Glu Ser Leu Asp Val Tyr Glu Leu 
            100                 105                 110         


Asp Ala Lys Gln Gly Arg Trp Tyr Val Val Gln Thr Asn Tyr Asp Arg 
        115                 120                 125             


Trp Lys His Pro Phe Phe Leu Asp Asp Arg Arg Thr Pro Ala Lys Met 
    130                 135                 140                 


Cys Leu Asn Arg Thr Ser Gln Glu Asn Ile Ser Phe Glu Thr Met Tyr 
145                 150                 155                 160 


Asp Val Leu Ser Thr Lys Pro Val Leu Asn Lys Leu Thr Val Tyr Thr 
                165                 170                 175     


Thr Leu Ile Asp Val Thr Lys Gly Gln Phe Glu Thr Tyr Leu Arg Asp 
            180                 185                 190         


Cys Pro Asp Pro Cys Ile Gly Trp 
        195                 200 


<210>  1196
<211>  51
<212>  PRT
<213>  Homo Sapiens

<400>  1196

Ala Gln Arg Tyr Glu Ala Ala Ser Thr Ile Tyr Gly Pro His Thr Leu 
1               5                   10                  15      


Ser Ala Tyr Ile Gln Leu Phe Arg Asn Leu Ala Lys Ala Ile Ala Thr 
            20                  25                  30          


Glu Leu His Leu Trp Lys Ser Ser Leu Trp Met Gln Leu Phe Met Lys 
        35                  40                  45              


Leu Gln Leu 
    50      


<210>  1197
<211>  144
<212>  PRT
<213>  Homo Sapiens

<400>  1197

Ala Gln Arg Tyr Glu Ala Ala Ser Thr Ile Tyr Gly Pro His Thr Leu 
1               5                   10                  15      


Ser Ala Tyr Ile Gln Leu Phe Arg Asn Leu Ala Lys Ala Ile Ala Thr 
            20                  25                  30          


Gly Glu Val Ala Glu Val Ile Phe Val Gly Ala Asn Pro Lys Asn Ser 
        35                  40                  45              


Val Gln Asn Gln Thr His Gln Thr Phe Leu Thr Val Glu Lys Tyr Glu 
    50                  55                  60                  


Ala Thr Ser Thr Ser Trp Gln Ile Val Cys Asn Asp Ala Ser Trp Glu 
65                  70                  75                  80  


Thr Arg Phe Tyr Trp His Lys Gly Leu Leu Gly Leu Ser Asn Ala Thr 
                85                  90                  95      


Val Glu Trp His Ile Pro Asp Thr Ala Gln Pro Gly Ile Tyr Arg Ile 
            100                 105                 110         


Arg Tyr Phe Gly His Asn Arg Lys Gln Asp Ile Leu Lys Pro Ala Val 
        115                 120                 125             


Ile Leu Ser Phe Glu Gly Thr Ser Pro Ala Phe Glu Val Val Thr Ile 
    130                 135                 140                 


<210>  1198
<211>  780
<212>  PRT
<213>  Homo Sapiens

<400>  1198

Met Ala Lys Arg Thr Phe Ser Asn Leu Glu Thr Phe Leu Ile Phe Leu 
1               5                   10                  15      


Leu Val Met Met Ser Ala Ile Thr Val Ala Leu Leu Ser Leu Leu Phe 
            20                  25                  30          


Ile Thr Ser Gly Thr Ile Glu Asn His Lys Asp Leu Gly Gly His Phe 
        35                  40                  45              


Phe Ser Thr Thr Gln Ser Pro Pro Ala Thr Gln Gly Ser Thr Ala Ala 
    50                  55                  60                  


Gln Arg Ser Thr Ala Thr Gln His Ser Thr Ala Thr Gln Ser Ser Thr 
65                  70                  75                  80  


Ala Thr Gln Thr Ser Pro Val Pro Leu Thr Pro Glu Ser Pro Leu Phe 
                85                  90                  95      


Gln Asn Phe Ser Gly Tyr His Ile Gly Val Gly Arg Ala Asp Cys Thr 
            100                 105                 110         


Gly Gln Val Ala Asp Ile Asn Leu Met Gly Tyr Gly Lys Ser Gly Gln 
        115                 120                 125             


Asn Ala Gln Gly Ile Leu Thr Arg Leu Tyr Ser Arg Ala Phe Ile Met 
    130                 135                 140                 


Ala Glu Pro Asp Gly Ser Asn Arg Thr Val Phe Val Ser Ile Asp Ile 
145                 150                 155                 160 


Gly Met Val Ser Gln Arg Leu Arg Leu Glu Val Leu Asn Arg Leu Gln 
                165                 170                 175     


Ser Lys Tyr Gly Ser Leu Tyr Arg Arg Asp Asn Val Ile Leu Ser Gly 
            180                 185                 190         


Thr His Thr His Ser Gly Pro Ala Gly Tyr Phe Gln Tyr Thr Val Phe 
        195                 200                 205             


Val Ile Ala Ser Glu Gly Phe Ser Asn Gln Thr Phe Gln His Met Val 
    210                 215                 220                 


Thr Gly Ile Leu Lys Ser Ile Asp Ile Ala His Thr Asn Met Lys Pro 
225                 230                 235                 240 


Gly Lys Ile Phe Ile Asn Lys Gly Asn Val Asp Gly Val Gln Ile Asn 
                245                 250                 255     


Arg Ser Pro Tyr Ser Tyr Leu Gln Asn Pro Gln Ser Glu Arg Ala Arg 
            260                 265                 270         


Tyr Ser Ser Asn Thr Asp Lys Glu Met Ile Val Leu Lys Met Val Asp 
        275                 280                 285             


Leu Asn Gly Asp Asp Leu Gly Leu Ile Ser Trp Phe Ala Ile His Pro 
    290                 295                 300                 


Val Ser Met Asn Asn Ser Asn His Leu Val Asn Ser Asp Asn Val Gly 
305                 310                 315                 320 


Tyr Ala Ser Tyr Leu Leu Glu Gln Glu Lys Asn Lys Gly Tyr Leu Pro 
                325                 330                 335     


Gly Gln Gly Pro Phe Val Ala Ala Phe Ala Ser Ser Asn Leu Gly Asp 
            340                 345                 350         


Val Ser Pro Asn Ile Leu Gly Pro Arg Cys Ile Asn Thr Gly Glu Ser 
        355                 360                 365             


Cys Asp Asn Ala Asn Ser Thr Cys Pro Ile Gly Gly Pro Ser Met Cys 
    370                 375                 380                 


Ile Ala Lys Gly Pro Gly Gln Asp Met Phe Asp Ser Thr Gln Ile Ile 
385                 390                 395                 400 


Gly Arg Ala Met Tyr Gln Arg Ala Lys Glu Leu Tyr Ala Ser Ala Ser 
                405                 410                 415     


Gln Glu Val Thr Gly Pro Leu Ala Ser Ala His Gln Trp Val Asp Met 
            420                 425                 430         


Thr Asp Val Thr Val Trp Leu Asn Ser Thr His Ala Ser Lys Thr Cys 
        435                 440                 445             


Lys Pro Ala Leu Gly Tyr Ser Phe Ala Ala Gly Thr Ile Asp Gly Val 
    450                 455                 460                 


Gly Gly Leu Asn Phe Thr Gln Gly Lys Thr Glu Gly Asp Pro Phe Trp 
465                 470                 475                 480 


Asp Thr Ile Arg Asp Gln Ile Leu Gly Lys Pro Ser Glu Glu Ile Lys 
                485                 490                 495     


Glu Cys His Lys Pro Lys Pro Ile Leu Leu His Thr Gly Glu Leu Ser 
            500                 505                 510         


Lys Pro His Pro Trp His Pro Asp Ile Val Asp Val Gln Ile Ile Thr 
        515                 520                 525             


Leu Gly Ser Leu Ala Ile Thr Ala Ile Pro Gly Glu Phe Thr Thr Met 
    530                 535                 540                 


Ser Gly Arg Arg Leu Arg Glu Ala Val Gln Ala Glu Phe Ala Ser His 
545                 550                 555                 560 


Gly Met Gln Asn Met Thr Val Val Ile Ser Gly Leu Cys Asn Val Tyr 
                565                 570                 575     


Thr His Tyr Ile Thr Thr Tyr Glu Glu Tyr Gln Ala Gln Arg Tyr Glu 
            580                 585                 590         


Ala Ala Ser Thr Ile Tyr Gly Pro His Thr Leu Ser Ala Tyr Ile Gln 
        595                 600                 605             


Leu Phe Arg Asn Leu Ala Lys Ala Ile Ala Thr Asp Thr Val Ala Asn 
    610                 615                 620                 


Leu Ser Arg Gly Pro Glu Pro Pro Phe Phe Lys Gln Leu Ile Val Pro 
625                 630                 635                 640 


Leu Ile Pro Ser Ile Val Asp Arg Ala Pro Lys Gly Arg Thr Phe Gly 
                645                 650                 655     


Asp Val Leu Gln Pro Ala Lys Pro Glu Tyr Arg Val Gly Glu Val Ala 
            660                 665                 670         


Glu Val Ile Phe Val Gly Ala Asn Pro Lys Asn Ser Val Gln Asn Gln 
        675                 680                 685             


Thr His Gln Thr Phe Leu Thr Val Glu Lys Tyr Glu Ala Thr Ser Thr 
    690                 695                 700                 


Ser Trp Gln Ile Val Cys Asn Asp Ala Ser Trp Glu Thr Arg Phe Tyr 
705                 710                 715                 720 


Trp His Lys Gly Leu Leu Gly Leu Ser Asn Ala Thr Val Glu Trp His 
                725                 730                 735     


Ile Pro Asp Thr Ala Gln Pro Gly Ile Tyr Arg Ile Arg Tyr Phe Gly 
            740                 745                 750         


His Asn Arg Lys Gln Asp Ile Leu Lys Pro Ala Val Ile Leu Ser Phe 
        755                 760                 765             


Glu Gly Thr Ser Pro Ala Phe Glu Val Val Thr Ile 
    770                 775                 780 


<210>  1199
<211>  745
<212>  PRT
<213>  Homo Sapiens

<400>  1199

Met Ala Lys Arg Thr Phe Ser Asn Leu Glu Thr Phe Leu Ile Phe Leu 
1               5                   10                  15      


Leu Val Met Met Ser Ala Ile Thr Val Ala Leu Leu Ser Leu Leu Phe 
            20                  25                  30          


Ile Thr Ser Gly Thr Ile Glu Asn His Lys Asp Leu Gly Gly His Phe 
        35                  40                  45              


Phe Ser Thr Thr Gln Ser Pro Pro Ala Thr Gln Gly Ser Thr Ala Ala 
    50                  55                  60                  


Gln Arg Ser Thr Ala Thr Gln His Ser Thr Ala Thr Gln Ser Ser Thr 
65                  70                  75                  80  


Ala Thr Gln Thr Ser Pro Val Pro Leu Thr Pro Glu Ser Pro Leu Phe 
                85                  90                  95      


Gln Asn Phe Ser Gly Tyr His Ile Gly Val Gly Arg Ala Asp Cys Thr 
            100                 105                 110         


Gly Gln Val Ala Asp Ile Asn Leu Met Gly Tyr Gly Lys Ser Gly Gln 
        115                 120                 125             


Asn Ala Gln Gly Ile Leu Thr Arg Leu Tyr Ser Arg Ala Phe Ile Met 
    130                 135                 140                 


Ala Glu Pro Asp Gly Ser Asn Arg Thr Val Phe Val Ser Ile Asp Ile 
145                 150                 155                 160 


Gly Met Val Ser Gln Arg Leu Arg Leu Glu Val Leu Asn Arg Leu Gln 
                165                 170                 175     


Ser Lys Tyr Gly Ser Leu Tyr Arg Arg Asp Asn Val Ile Leu Ser Gly 
            180                 185                 190         


Thr His Thr His Ser Gly Pro Ala Gly Tyr Phe Gln Tyr Thr Val Phe 
        195                 200                 205             


Val Ile Ala Ser Glu Gly Phe Ser Asn Gln Thr Phe Gln His Met Val 
    210                 215                 220                 


Thr Gly Ile Leu Lys Ser Ile Asp Ile Ala His Thr Asn Met Lys Pro 
225                 230                 235                 240 


Gly Lys Ile Phe Ile Asn Lys Gly Asn Val Asp Gly Val Gln Ile Asn 
                245                 250                 255     


Arg Ser Pro Tyr Ser Tyr Leu Gln Asn Pro Gln Ser Glu Arg Ala Arg 
            260                 265                 270         


Tyr Ser Ser Asn Thr Asp Lys Glu Met Ile Val Leu Lys Met Val Asp 
        275                 280                 285             


Leu Asn Gly Asp Asp Leu Gly Leu Ile Ser Trp Phe Ala Ile His Pro 
    290                 295                 300                 


Val Ser Met Asn Asn Ser Asn His Leu Val Asn Ser Asp Asn Val Gly 
305                 310                 315                 320 


Tyr Ala Ser Tyr Leu Leu Glu Gln Glu Lys Asn Lys Gly Tyr Leu Pro 
                325                 330                 335     


Gly Gln Gly Pro Phe Val Ala Ala Phe Ala Ser Ser Asn Leu Gly Asp 
            340                 345                 350         


Val Ser Pro Asn Ile Leu Gly Pro Arg Cys Ile Asn Thr Gly Glu Ser 
        355                 360                 365             


Cys Asp Asn Ala Asn Ser Thr Cys Pro Ile Gly Gly Pro Ser Met Cys 
    370                 375                 380                 


Ile Ala Lys Gly Pro Gly Gln Asp Met Phe Asp Ser Thr Gln Ile Ile 
385                 390                 395                 400 


Gly Arg Ala Met Tyr Gln Arg Ala Lys Ser Lys Thr Cys Lys Pro Ala 
                405                 410                 415     


Leu Gly Tyr Ser Phe Ala Ala Gly Thr Ile Asp Gly Val Gly Gly Leu 
            420                 425                 430         


Asn Phe Thr Gln Gly Lys Thr Glu Gly Asp Pro Phe Trp Asp Thr Ile 
        435                 440                 445             


Arg Asp Gln Ile Leu Gly Lys Pro Ser Glu Glu Ile Lys Glu Cys His 
    450                 455                 460                 


Lys Pro Lys Pro Ile Leu Leu His Thr Gly Glu Leu Ser Lys Pro His 
465                 470                 475                 480 


Pro Trp His Pro Asp Ile Val Asp Val Gln Ile Ile Thr Leu Gly Ser 
                485                 490                 495     


Leu Ala Ile Thr Ala Ile Pro Gly Glu Phe Thr Thr Met Ser Gly Arg 
            500                 505                 510         


Arg Leu Arg Glu Ala Val Gln Ala Glu Phe Ala Ser His Gly Met Gln 
        515                 520                 525             


Asn Met Thr Val Val Ile Ser Gly Leu Cys Asn Val Tyr Thr His Tyr 
    530                 535                 540                 


Ile Thr Thr Tyr Glu Glu Tyr Gln Ala Gln Arg Tyr Glu Ala Ala Ser 
545                 550                 555                 560 


Thr Ile Tyr Gly Pro His Thr Leu Ser Ala Tyr Ile Gln Leu Phe Arg 
                565                 570                 575     


Asn Leu Ala Lys Ala Ile Ala Thr Asp Thr Val Ala Asn Leu Ser Arg 
            580                 585                 590         


Gly Pro Glu Pro Pro Phe Phe Lys Gln Leu Ile Val Pro Leu Ile Pro 
        595                 600                 605             


Ser Ile Val Asp Arg Ala Pro Lys Gly Arg Thr Phe Gly Asp Val Leu 
    610                 615                 620                 


Gln Pro Ala Lys Pro Glu Tyr Arg Val Gly Glu Val Ala Glu Val Ile 
625                 630                 635                 640 


Phe Val Gly Ala Asn Pro Lys Asn Ser Val Gln Asn Gln Thr His Gln 
                645                 650                 655     


Thr Phe Leu Thr Val Glu Lys Tyr Glu Ala Thr Ser Thr Ser Trp Gln 
            660                 665                 670         


Ile Val Cys Asn Asp Ala Ser Trp Glu Thr Arg Phe Tyr Trp His Lys 
        675                 680                 685             


Gly Leu Leu Gly Leu Ser Asn Ala Thr Val Glu Trp His Ile Pro Asp 
    690                 695                 700                 


Thr Ala Gln Pro Gly Ile Tyr Arg Ile Arg Tyr Phe Gly His Asn Arg 
705                 710                 715                 720 


Lys Gln Asp Ile Leu Lys Pro Ala Val Ile Leu Ser Phe Glu Gly Thr 
                725                 730                 735     


Ser Pro Ala Phe Glu Val Val Thr Ile 
            740                 745 


<210>  1200
<211>  622
<212>  PRT
<213>  Homo Sapiens

<400>  1200

Met Asp Ser Glu Lys Ser Ser Glu Trp Arg Ser Asp Val Leu Asn Arg 
1               5                   10                  15      


Leu Gln Ser Lys Tyr Gly Ser Leu Tyr Arg Arg Asp Asn Val Ile Leu 
            20                  25                  30          


Ser Gly Thr His Thr His Ser Gly Pro Ala Gly Tyr Phe Gln Tyr Thr 
        35                  40                  45              


Val Phe Val Ile Ala Ser Glu Gly Phe Ser Asn Gln Thr Phe Gln His 
    50                  55                  60                  


Met Val Thr Gly Ile Leu Lys Ser Ile Asp Ile Ala His Thr Asn Met 
65                  70                  75                  80  


Lys Pro Gly Lys Ile Phe Ile Asn Lys Gly Asn Val Asp Gly Val Gln 
                85                  90                  95      


Ile Asn Arg Ser Pro Tyr Ser Tyr Leu Gln Asn Pro Gln Ser Glu Arg 
            100                 105                 110         


Ala Arg Tyr Ser Ser Asn Thr Asp Lys Glu Met Ile Val Leu Lys Met 
        115                 120                 125             


Val Asp Leu Asn Gly Asp Asp Leu Gly Leu Ile Ser Trp Phe Ala Ile 
    130                 135                 140                 


His Pro Val Ser Met Asn Asn Ser Asn His Leu Val Asn Ser Asp Asn 
145                 150                 155                 160 


Val Gly Tyr Ala Ser Tyr Leu Leu Glu Gln Glu Lys Asn Lys Gly Tyr 
                165                 170                 175     


Leu Pro Gly Gln Gly Pro Phe Val Ala Ala Phe Ala Ser Ser Asn Leu 
            180                 185                 190         


Gly Asp Val Ser Pro Asn Ile Leu Gly Pro Arg Cys Ile Asn Thr Gly 
        195                 200                 205             


Glu Ser Cys Asp Asn Ala Asn Ser Thr Cys Pro Ile Gly Gly Pro Ser 
    210                 215                 220                 


Met Cys Ile Ala Lys Gly Pro Gly Gln Asp Met Phe Asp Ser Thr Gln 
225                 230                 235                 240 


Ile Ile Gly Arg Ala Met Tyr Gln Arg Ala Lys Glu Leu Tyr Ala Ser 
                245                 250                 255     


Ala Ser Gln Glu Val Thr Gly Pro Leu Ala Ser Ala His Gln Trp Val 
            260                 265                 270         


Asp Met Thr Asp Val Thr Val Trp Leu Asn Ser Thr His Ala Ser Lys 
        275                 280                 285             


Thr Cys Lys Pro Ala Leu Gly Tyr Ser Phe Ala Ala Gly Thr Ile Asp 
    290                 295                 300                 


Gly Val Gly Gly Leu Asn Phe Thr Gln Gly Lys Thr Glu Gly Asp Pro 
305                 310                 315                 320 


Phe Trp Asp Thr Ile Arg Asp Gln Ile Leu Gly Lys Pro Ser Glu Glu 
                325                 330                 335     


Ile Lys Glu Cys His Lys Pro Lys Pro Ile Leu Leu His Thr Gly Glu 
            340                 345                 350         


Leu Ser Lys Pro His Pro Trp His Pro Asp Ile Val Asp Val Gln Ile 
        355                 360                 365             


Ile Thr Leu Gly Ser Leu Ala Ile Thr Ala Ile Pro Gly Glu Phe Thr 
    370                 375                 380                 


Thr Met Ser Gly Arg Arg Leu Arg Glu Ala Val Gln Ala Glu Phe Ala 
385                 390                 395                 400 


Ser His Gly Met Gln Asn Met Thr Val Val Ile Ser Gly Leu Cys Asn 
                405                 410                 415     


Val Tyr Thr His Tyr Ile Thr Thr Tyr Glu Glu Tyr Gln Ala Gln Arg 
            420                 425                 430         


Tyr Glu Ala Ala Ser Thr Ile Tyr Gly Pro His Thr Leu Ser Ala Tyr 
        435                 440                 445             


Ile Gln Leu Phe Arg Asn Leu Ala Lys Ala Ile Ala Thr Asp Thr Val 
    450                 455                 460                 


Ala Asn Leu Ser Arg Gly Pro Glu Pro Pro Phe Phe Lys Gln Leu Ile 
465                 470                 475                 480 


Val Pro Leu Ile Pro Ser Ile Val Asp Arg Ala Pro Lys Gly Arg Thr 
                485                 490                 495     


Phe Gly Asp Val Leu Gln Pro Ala Lys Pro Glu Tyr Arg Val Gly Glu 
            500                 505                 510         


Val Ala Glu Val Ile Phe Val Gly Ala Asn Pro Lys Asn Ser Val Gln 
        515                 520                 525             


Asn Gln Thr His Gln Thr Phe Leu Thr Val Glu Lys Tyr Glu Ala Thr 
    530                 535                 540                 


Ser Thr Ser Trp Gln Ile Val Cys Asn Asp Ala Ser Trp Glu Thr Arg 
545                 550                 555                 560 


Phe Tyr Trp His Lys Gly Leu Leu Gly Leu Ser Asn Ala Thr Val Glu 
                565                 570                 575     


Trp His Ile Pro Asp Thr Ala Gln Pro Gly Ile Tyr Arg Ile Arg Tyr 
            580                 585                 590         


Phe Gly His Asn Arg Lys Gln Asp Ile Leu Lys Pro Ala Val Ile Leu 
        595                 600                 605             


Ser Phe Glu Gly Thr Ser Pro Ala Phe Glu Val Val Thr Ile 
    610                 615                 620         


<210>  1201
<211>  726
<212>  PRT
<213>  Homo Sapiens

<400>  1201

Met Ser Ala Ile Thr Val Ala Leu Leu Ser Leu Leu Phe Ile Thr Ser 
1               5                   10                  15      


Gly Thr Ile Glu Asn His Lys Asp Leu Gly Gly His Phe Phe Ser Thr 
            20                  25                  30          


Thr Gln Ser Pro Pro Ala Thr Gln Gly Ser Thr Ala Ala Gln Arg Ser 
        35                  40                  45              


Thr Ala Thr Gln His Ser Thr Ala Thr Gln Ser Ser Thr Ala Thr Gln 
    50                  55                  60                  


Thr Ser Pro Val Pro Leu Thr Pro Glu Ser Pro Leu Phe Gln Asn Phe 
65                  70                  75                  80  


Ser Gly Tyr His Ile Gly Val Gly Arg Ala Asp Cys Thr Gly Gln Val 
                85                  90                  95      


Ala Asp Ile Asn Leu Met Gly Tyr Gly Lys Ser Gly Gln Asn Ala Gln 
            100                 105                 110         


Gly Ile Leu Thr Arg Leu Tyr Ser Arg Ala Phe Ile Met Ala Glu Pro 
        115                 120                 125             


Asp Gly Ser Asn Arg Thr Val Phe Val Ser Ile Asp Ile Gly Met Val 
    130                 135                 140                 


Ser Gln Arg Leu Arg Leu Glu Val Leu Asn Arg Leu Gln Ser Lys Tyr 
145                 150                 155                 160 


Gly Ser Leu Tyr Arg Arg Asp Asn Val Ile Leu Ser Gly Thr His Thr 
                165                 170                 175     


His Ser Gly Pro Ala Gly Tyr Phe Gln Tyr Thr Val Phe Val Ile Ala 
            180                 185                 190         


Ser Glu Gly Phe Ser Asn Gln Thr Phe Gln His Met Val Thr Gly Ile 
        195                 200                 205             


Leu Lys Ser Ile Asp Ile Ala His Thr Asn Met Lys Pro Gly Lys Ile 
    210                 215                 220                 


Phe Ile Asn Lys Gly Asn Val Asp Gly Val Gln Ile Asn Arg Ser Pro 
225                 230                 235                 240 


Tyr Ser Tyr Leu Gln Asn Pro Gln Ser Glu Arg Ala Arg Tyr Ser Ser 
                245                 250                 255     


Asn Thr Asp Lys Glu Met Ile Val Leu Lys Met Val Asp Leu Asn Gly 
            260                 265                 270         


Asp Asp Leu Gly Leu Ile Ser Trp Phe Ala Ile His Pro Val Ser Met 
        275                 280                 285             


Asn Asn Ser Asn His Leu Val Asn Ser Asp Asn Val Gly Tyr Ala Ser 
    290                 295                 300                 


Tyr Leu Leu Glu Gln Glu Lys Asn Lys Gly Tyr Leu Pro Gly Gln Gly 
305                 310                 315                 320 


Pro Phe Val Ala Ala Phe Ala Ser Ser Asn Leu Gly Asp Val Ser Pro 
                325                 330                 335     


Asn Ile Leu Gly Pro Arg Cys Ile Asn Thr Gly Glu Ser Cys Asp Asn 
            340                 345                 350         


Ala Asn Ser Thr Cys Pro Ile Gly Gly Pro Ser Met Cys Ile Ala Lys 
        355                 360                 365             


Gly Pro Gly Gln Asp Met Phe Asp Ser Thr Gln Ile Ile Gly Arg Ala 
    370                 375                 380                 


Met Tyr Gln Arg Ala Lys Ser Lys Thr Cys Lys Pro Ala Leu Gly Tyr 
385                 390                 395                 400 


Ser Phe Ala Ala Gly Thr Ile Asp Gly Val Gly Gly Leu Asn Phe Thr 
                405                 410                 415     


Gln Gly Lys Thr Glu Gly Asp Pro Phe Trp Asp Thr Ile Arg Asp Gln 
            420                 425                 430         


Ile Leu Gly Lys Pro Ser Glu Glu Ile Lys Glu Cys His Lys Pro Lys 
        435                 440                 445             


Pro Ile Leu Leu His Thr Gly Glu Leu Ser Lys Pro His Pro Trp His 
    450                 455                 460                 


Pro Asp Ile Val Asp Val Gln Ile Ile Thr Leu Gly Ser Leu Ala Ile 
465                 470                 475                 480 


Thr Ala Ile Pro Gly Glu Phe Thr Thr Met Ser Gly Arg Arg Leu Arg 
                485                 490                 495     


Glu Ala Val Gln Ala Glu Phe Ala Ser His Gly Met Gln Asn Met Thr 
            500                 505                 510         


Val Val Ile Ser Gly Leu Cys Asn Val Tyr Thr His Tyr Ile Thr Thr 
        515                 520                 525             


Tyr Glu Glu Tyr Gln Ala Gln Arg Tyr Glu Ala Ala Ser Thr Ile Tyr 
    530                 535                 540                 


Gly Pro His Thr Leu Ser Ala Tyr Ile Gln Leu Phe Arg Asn Leu Ala 
545                 550                 555                 560 


Lys Ala Ile Ala Thr Asp Thr Val Ala Asn Leu Ser Arg Gly Pro Glu 
                565                 570                 575     


Pro Pro Phe Phe Lys Gln Leu Ile Val Pro Leu Ile Pro Ser Ile Val 
            580                 585                 590         


Asp Arg Ala Pro Lys Gly Arg Thr Phe Gly Asp Val Leu Gln Pro Ala 
        595                 600                 605             


Lys Pro Glu Tyr Arg Val Gly Glu Val Ala Glu Val Ile Phe Val Gly 
    610                 615                 620                 


Ala Asn Pro Lys Asn Ser Val Gln Asn Gln Thr His Gln Thr Phe Leu 
625                 630                 635                 640 


Thr Val Glu Lys Tyr Glu Ala Thr Ser Thr Ser Trp Gln Ile Val Cys 
                645                 650                 655     


Asn Asp Ala Ser Trp Glu Thr Arg Phe Tyr Trp His Lys Gly Leu Leu 
            660                 665                 670         


Gly Leu Ser Asn Ala Thr Val Glu Trp His Ile Pro Asp Thr Ala Gln 
        675                 680                 685             


Pro Gly Ile Tyr Arg Ile Arg Tyr Phe Gly His Asn Arg Lys Gln Asp 
    690                 695                 700                 


Ile Leu Lys Pro Ala Val Ile Leu Ser Phe Glu Gly Thr Ser Pro Ala 
705                 710                 715                 720 


Phe Glu Val Val Thr Ile 
                725     


<210>  1202
<211>  236
<212>  PRT
<213>  Homo Sapiens

<400>  1202

Met Glu Ser Ser Ala Lys Met Glu Ser Gly Gly Ala Gly Gln Gln Pro 
1               5                   10                  15      


Gln Pro Gln Pro Gln Gln Pro Phe Leu Pro Pro Ala Ala Cys Phe Phe 
            20                  25                  30          


Ala Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gln 
        35                  40                  45              


Ser Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ala Pro 
    50                  55                  60                  


Gln Leu Arg Pro Ala Ala Asp Gly Gln Pro Ser Gly Gly Gly His Lys 
65                  70                  75                  80  


Ser Ala Pro Lys Gln Val Lys Arg Gln Arg Ser Ser Ser Pro Glu Leu 
                85                  90                  95      


Met Arg Cys Lys Arg Arg Leu Asn Phe Ser Gly Phe Gly Tyr Ser Leu 
            100                 105                 110         


Pro Gln Gln Gln Pro Ala Ala Val Ala Arg Arg Asn Glu Arg Glu Arg 
        115                 120                 125             


Asn Arg Val Lys Leu Val Asn Leu Gly Phe Ala Thr Leu Arg Glu His 
    130                 135                 140                 


Val Pro Asn Gly Ala Ala Asn Lys Lys Met Ser Lys Val Glu Thr Leu 
145                 150                 155                 160 


Arg Ser Ala Val Glu Tyr Ile Arg Ala Leu Gln Gln Leu Leu Asp Glu 
                165                 170                 175     


His Asp Ala Val Ser Ala Ala Phe Gln Ala Gly Val Leu Ser Pro Thr 
            180                 185                 190         


Ile Ser Pro Asn Tyr Ser Asn Asp Leu Asn Ser Met Ala Gly Ser Pro 
        195                 200                 205             


Val Ser Ser Tyr Ser Ser Asp Glu Gly Ser Tyr Asp Pro Leu Ser Pro 
    210                 215                 220                 


Glu Glu Gln Glu Leu Leu Asp Phe Thr Asn Trp Phe 
225                 230                 235     


<210>  1203
<211>  132
<212>  PRT
<213>  Homo Sapiens

<400>  1203

Met Asp Val Thr Arg Leu Leu Leu Ala Thr Leu Leu Val Phe Leu Cys 
1               5                   10                  15      


Phe Phe Thr Ala Asn Ser His Leu Pro Pro Glu Glu Lys Leu Arg Asp 
            20                  25                  30          


Asp Arg Ser Leu Arg Ser Asn Ser Ser Val Asn Leu Leu Asp Val Pro 
        35                  40                  45              


Ser Val Ser Ile Val Ala Leu Asn Lys Lys Ser Lys Gln Ile Gly Arg 
    50                  55                  60                  


Lys Ala Ala Glu Lys Lys Arg Ser Ser Lys Lys Glu Ala Ser Met Lys 
65                  70                  75                  80  


Lys Val Val Arg Pro Arg Thr Pro Leu Ser Ala Pro Cys Val Ala Thr 
                85                  90                  95      


Arg Asn Ser Cys Lys Pro Pro Ala Pro Ala Cys Cys Asp Pro Cys Ala 
            100                 105                 110         


Ser Cys Gln Cys Arg Phe Phe Arg Ser Ala Cys Ser Cys Arg Val Leu 
        115                 120                 125             


Ser Leu Asn Cys 
    130         


<210>  1204
<211>  132
<212>  PRT
<213>  Homo Sapiens

<400>  1204

Met Asp Val Thr Arg Leu Leu Leu Ala Thr Leu Leu Val Phe Leu Cys 
1               5                   10                  15      


Phe Phe Thr Ala Asn Ser His Leu Pro Pro Glu Glu Lys Leu Arg Asp 
            20                  25                  30          


Asp Arg Ser Leu Arg Ser Asn Ser Ser Val Asn Leu Leu Asp Val Pro 
        35                  40                  45              


Ser Val Ser Ile Val Ala Leu Asn Lys Lys Ser Lys Gln Ile Gly Arg 
    50                  55                  60                  


Lys Ala Ala Glu Lys Lys Arg Ser Ser Lys Lys Glu Ala Ser Met Lys 
65                  70                  75                  80  


Lys Val Val Arg Pro Arg Thr Pro Leu Ser Ala Pro Cys Val Ala Thr 
                85                  90                  95      


Arg Asn Ser Cys Lys Pro Pro Ala Pro Ala Cys Cys Asp Pro Cys Ala 
            100                 105                 110         


Ser Cys Gln Cys Arg Phe Phe Arg Ser Ala Cys Ser Cys Arg Val Leu 
        115                 120                 125             


Ser Leu Asn Cys 
    130         


<210>  1205
<211>  243
<212>  PRT
<213>  Homo Sapiens

<400>  1205

Met Lys Glu Tyr Val Leu Leu Leu Phe Leu Ala Leu Cys Ser Ala Lys 
1               5                   10                  15      


Pro Phe Phe Ser Pro Ser His Ile Ala Leu Lys Asn Met Met Leu Lys 
            20                  25                  30          


Asp Met Glu Asp Thr Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp 
        35                  40                  45              


Asp Asp Asp Glu Asp Asn Ser Leu Phe Pro Thr Arg Glu Pro Arg Ser 
    50                  55                  60                  


His Phe Phe Pro Phe Asp Leu Phe Pro Met Cys Pro Phe Gly Cys Gln 
65                  70                  75                  80  


Cys Tyr Ser Arg Val Val His Cys Ser Asp Leu Gly Leu Thr Ser Val 
                85                  90                  95      


Pro Thr Asn Ile Pro Phe Asp Thr Arg Met Leu Asp Leu Gln Asn Asn 
            100                 105                 110         


Lys Ile Lys Glu Ile Lys Glu Asn Asp Phe Lys Gly Leu Thr Ser Leu 
        115                 120                 125             


Tyr Gly Leu Ile Leu Asn Asn Asn Lys Leu Thr Lys Ile His Pro Lys 
    130                 135                 140                 


Ala Phe Leu Thr Thr Lys Lys Leu Arg Arg Leu Tyr Leu Ser His Asn 
145                 150                 155                 160 


Gln Leu Ser Glu Ile Pro Leu Asn Leu Pro Lys Ser Leu Ala Glu Leu 
                165                 170                 175     


Arg Ile His Glu Asn Lys Val Lys Lys Ile Gln Lys Asp Thr Phe Lys 
            180                 185                 190         


Gly Met Asn Ala Leu His Val Leu Glu Met Ser Ala Asn Pro Leu Asp 
        195                 200                 205             


Asn Asn Gly Ile Glu Pro Gly Ala Phe Glu Gly Val Thr Val Phe His 
    210                 215                 220                 


Ile Arg Ile Ala Glu Ala Lys Leu Thr Ser Val Pro Lys Asp Asn Leu 
225                 230                 235                 240 


Pro Ser Phe 
            


<210>  1206
<211>  380
<212>  PRT
<213>  Homo Sapiens

<400>  1206

Met Lys Glu Tyr Val Leu Leu Leu Phe Leu Ala Leu Cys Ser Ala Lys 
1               5                   10                  15      


Pro Phe Phe Ser Pro Ser His Ile Ala Leu Lys Asn Met Met Leu Lys 
            20                  25                  30          


Asp Met Glu Asp Thr Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp 
        35                  40                  45              


Asp Asp Asp Glu Asp Asn Ser Leu Phe Pro Thr Arg Glu Pro Arg Ser 
    50                  55                  60                  


His Phe Phe Pro Phe Asp Leu Phe Pro Met Cys Pro Phe Gly Cys Gln 
65                  70                  75                  80  


Cys Tyr Ser Arg Val Val His Cys Ser Asp Leu Gly Leu Thr Ser Val 
                85                  90                  95      


Pro Thr Asn Ile Pro Phe Asp Thr Arg Met Leu Asp Leu Gln Asn Asn 
            100                 105                 110         


Lys Ile Lys Glu Ile Lys Glu Asn Asp Phe Lys Gly Leu Thr Ser Leu 
        115                 120                 125             


Tyr Gly Leu Ile Leu Asn Asn Asn Lys Leu Thr Lys Ile His Pro Lys 
    130                 135                 140                 


Ala Phe Leu Thr Thr Lys Lys Leu Arg Arg Leu Tyr Leu Ser His Asn 
145                 150                 155                 160 


Gln Leu Ser Glu Ile Pro Leu Asn Leu Pro Lys Ser Leu Ala Glu Leu 
                165                 170                 175     


Arg Ile His Glu Asn Lys Val Lys Lys Ile Gln Lys Asp Thr Phe Lys 
            180                 185                 190         


Gly Met Asn Ala Leu His Val Leu Glu Met Ser Ala Asn Pro Leu Asp 
        195                 200                 205             


Asn Asn Gly Ile Glu Pro Gly Ala Phe Glu Gly Val Thr Val Phe His 
    210                 215                 220                 


Ile Arg Ile Ala Glu Ala Lys Leu Thr Ser Val Pro Lys Gly Leu Pro 
225                 230                 235                 240 


Pro Thr Leu Leu Glu Leu His Leu Asp Tyr Asn Lys Ile Ser Thr Val 
                245                 250                 255     


Glu Leu Glu Asp Phe Lys Arg Tyr Lys Glu Leu Gln Arg Leu Gly Leu 
            260                 265                 270         


Gly Asn Asn Lys Ile Thr Asp Ile Glu Asn Gly Ser Leu Ala Asn Ile 
        275                 280                 285             


Pro Arg Val Arg Glu Ile His Leu Glu Asn Asn Lys Leu Lys Lys Ile 
    290                 295                 300                 


Pro Ser Gly Leu Pro Glu Leu Lys Tyr Leu Gln Ile Ile Phe Leu His 
305                 310                 315                 320 


Ser Asn Ser Ile Ala Arg Val Gly Val Asn Asp Phe Cys Pro Thr Val 
                325                 330                 335     


Pro Lys Met Lys Lys Ser Leu Tyr Ser Ala Ile Ser Leu Phe Asn Asn 
            340                 345                 350         


Pro Val Lys Tyr Trp Glu Met Gln Pro Ala Thr Phe Arg Cys Val Leu 
        355                 360                 365             


Ser Arg Met Ser Val Gln Leu Gly Asn Phe Gly Met 
    370                 375                 380 


<210>  1207
<211>  431
<212>  PRT
<213>  Homo Sapiens

<400>  1207

Met Glu Gly Val Gly Gly Leu Trp Pro Trp Val Leu Gly Leu Leu Ser 
1               5                   10                  15      


Leu Pro Gly Val Ile Leu Gly Ala Pro Leu Ala Ser Ser Cys Ala Gly 
            20                  25                  30          


Ala Cys Gly Thr Ser Phe Pro Asp Gly Leu Thr Pro Glu Gly Thr Gln 
        35                  40                  45              


Ala Ser Gly Asp Lys Asp Ile Pro Ala Ile Asn Gln Gly Leu Ile Leu 
    50                  55                  60                  


Glu Glu Thr Pro Glu Ser Ser Phe Leu Ile Glu Gly Asp Ile Ile Arg 
65                  70                  75                  80  


Pro Ser Pro Phe Arg Leu Leu Ser Ala Thr Ser Asn Lys Trp Pro Met 
                85                  90                  95      


Gly Gly Ser Gly Val Val Glu Val Pro Phe Leu Leu Ser Ser Lys Tyr 
            100                 105                 110         


Asp Glu Pro Ser Arg Gln Val Ile Leu Glu Ala Leu Ala Glu Phe Glu 
        115                 120                 125             


Arg Ser Thr Cys Ile Arg Phe Val Thr Tyr Gln Asp Gln Arg Asp Phe 
    130                 135                 140                 


Ile Ser Ile Ile Pro Met Tyr Gly Cys Phe Ser Ser Val Gly Arg Ser 
145                 150                 155                 160 


Gly Gly Met Gln Val Val Ser Leu Ala Pro Thr Cys Leu Gln Lys Gly 
                165                 170                 175     


Arg Gly Ile Val Leu His Glu Leu Met His Val Leu Gly Phe Trp His 
            180                 185                 190         


Glu His Thr Arg Ala Asp Arg Asp Arg Tyr Ile Arg Val Asn Trp Asn 
        195                 200                 205             


Glu Ile Leu Pro Gly Phe Glu Ile Asn Phe Ile Lys Ser Gln Ser Ser 
    210                 215                 220                 


Asn Met Leu Thr Pro Tyr Asp Tyr Ser Ser Val Met His Tyr Gly Arg 
225                 230                 235                 240 


Leu Ala Phe Ser Arg Arg Gly Leu Pro Thr Ile Thr Pro Leu Trp Ala 
                245                 250                 255     


Pro Ser Val His Ile Gly Gln Arg Trp Asn Leu Ser Ala Ser Asp Ile 
            260                 265                 270         


Thr Arg Val Leu Lys Leu Tyr Gly Cys Ser Pro Ser Gly Pro Arg Pro 
        275                 280                 285             


Arg Gly Arg Gly Ser His Ala His Ser Thr Gly Arg Ser Pro Ala Pro 
    290                 295                 300                 


Ala Ser Leu Ser Leu Gln Arg Leu Leu Glu Ala Leu Ser Ala Glu Ser 
305                 310                 315                 320 


Arg Ser Pro Asp Pro Ser Gly Ser Ser Ala Gly Gly Gln Pro Val Pro 
                325                 330                 335     


Ala Gly Pro Gly Glu Ser Pro His Gly Trp Glu Ser Pro Ala Leu Lys 
            340                 345                 350         


Lys Leu Ser Ala Glu Ala Ser Ala Arg Gln Pro Gln Thr Leu Ala Ser 
        355                 360                 365             


Ser Pro Arg Ser Arg Pro Gly Ala Gly Ala Pro Gly Val Ala Gln Glu 
    370                 375                 380                 


Gln Ser Trp Leu Ala Gly Val Ser Thr Lys Pro Thr Val Pro Ser Ser 
385                 390                 395                 400 


Glu Ala Gly Ile Gln Pro Val Pro Val Gln Gly Ser Pro Ala Leu Pro 
                405                 410                 415     


Gly Gly Cys Val Pro Arg Asn His Phe Lys Gly Met Ser Glu Asp 
            420                 425                 430     


<210>  1208
<211>  1844
<212>  PRT
<213>  Homo Sapiens

<400>  1208

Met Val Gly Val Leu Ala Met Ala Ala Ala Ala Ala Pro Pro Pro Val 
1               5                   10                  15      


Lys Asp Cys Glu Ile Glu Pro Cys Lys Lys Arg Lys Lys Asp Asp Asp 
            20                  25                  30          


Thr Ser Thr Cys Lys Thr Ile Thr Lys Tyr Leu Ser Pro Leu Gly Lys 
        35                  40                  45              


Thr Arg Asp Arg Val Phe Ala Pro Pro Lys Pro Ser Asn Ile Leu Asp 
    50                  55                  60                  


Tyr Phe Arg Lys Thr Ser Pro Thr Asn Glu Lys Thr Gln Leu Gly Lys 
65                  70                  75                  80  


Glu Cys Lys Ile Lys Ser Pro Glu Ser Val Pro Val Asp Ser Asn Lys 
                85                  90                  95      


Asp Cys Thr Thr Pro Leu Glu Met Phe Ser Asn Val Glu Phe Lys Lys 
            100                 105                 110         


Lys Arg Lys Arg Val Asn Leu Ser His Gln Leu Asn Asn Ile Lys Thr 
        115                 120                 125             


Glu Asn Glu Ala Pro Ile Glu Ile Ser Ser Asp Asp Ser Lys Glu Asp 
    130                 135                 140                 


Tyr Ser Leu Asn Asn Asp Phe Val Glu Ser Ser Thr Ser Val Leu Arg 
145                 150                 155                 160 


Tyr Lys Lys Gln Val Glu Val Leu Ala Glu Asn Ile Gln Asp Thr Lys 
                165                 170                 175     


Ser Gln Pro Asn Thr Met Thr Ser Leu Gln Asn Ser Lys Lys Val Asn 
            180                 185                 190         


Pro Lys Gln Gly Thr Thr Lys Asn Asp Phe Lys Lys Leu Arg Lys Arg 
        195                 200                 205             


Lys Cys Arg Asp Val Val Asp Leu Ser Glu Ser Leu Pro Leu Ala Glu 
    210                 215                 220                 


Glu Leu Asn Leu Leu Lys Lys Asp Gly Lys Asp Thr Lys Gln Met Glu 
225                 230                 235                 240 


Asn Thr Thr Ser His Ala Asn Ser Arg Asp Asn Val Thr Glu Ala Ala 
                245                 250                 255     


Gln Leu Asn Asp Ser Ile Ile Thr Val Ser Tyr Glu Glu Phe Leu Lys 
            260                 265                 270         


Ser His Lys Glu Asn Lys Val Glu Glu Ile Pro Asp Ser Thr Met Ser 
        275                 280                 285             


Ile Cys Val Pro Ser Glu Thr Val Asp Glu Ile Val Lys Ser Gly Tyr 
    290                 295                 300                 


Ile Ser Glu Ser Glu Asn Ser Glu Ile Ser Gln Gln Val Arg Phe Lys 
305                 310                 315                 320 


Thr Val Thr Val Leu Ala Gln Val His Pro Ile Pro Pro Lys Lys Thr 
                325                 330                 335     


Gly Lys Ile Pro Arg Ile Phe Leu Lys Gln Lys Gln Phe Glu Met Glu 
            340                 345                 350         


Asn Ser Leu Ser Asp Pro Glu Asn Glu Gln Thr Val Gln Lys Arg Lys 
        355                 360                 365             


Ser Asn Val Val Ile Gln Glu Glu Glu Leu Glu Leu Ala Val Leu Glu 
    370                 375                 380                 


Ala Gly Ser Ser Glu Ala Val Lys Pro Lys Cys Thr Leu Glu Glu Arg 
385                 390                 395                 400 


Gln Gln Phe Met Lys Ala Phe Arg Gln Pro Ala Ser Asp Ala Leu Lys 
                405                 410                 415     


Asn Gly Val Lys Lys Ser Ser Asp Lys Gln Lys Asp Leu Asn Glu Lys 
            420                 425                 430         


Cys Leu Tyr Glu Val Gly Arg Asp Asp Asn Ser Lys Lys Ile Met Glu 
        435                 440                 445             


Asn Ser Gly Ile Gln Met Val Ser Lys Asn Gly Asn Leu Gln Leu His 
    450                 455                 460                 


Thr Asp Lys Gly Ser Phe Leu Lys Glu Lys Asn Lys Lys Leu Lys Lys 
465                 470                 475                 480 


Lys Asn Lys Lys Thr Leu Asp Thr Gly Ala Ile Pro Gly Lys Asn Arg 
                485                 490                 495     


Glu Gly Asn Thr Gln Lys Lys Glu Thr Thr Phe Phe Leu Lys Glu Lys 
            500                 505                 510         


Gln Tyr Gln Asn Arg Met Ser Leu Arg Gln Arg Lys Thr Glu Phe Phe 
        515                 520                 525             


Lys Ser Ser Thr Leu Phe Asn Asn Glu Ser Leu Val Tyr Glu Asp Ile 
    530                 535                 540                 


Ala Asn Asp Asp Leu Leu Lys Val Ser Ser Leu Cys Asn Asn Asn Lys 
545                 550                 555                 560 


Leu Ser Arg Lys Thr Ser Ile Pro Val Lys Asp Ile Lys Leu Thr Gln 
                565                 570                 575     


Ser Lys Ala Glu Ser Glu Ala Ser Leu Leu Asn Val Ser Thr Pro Lys 
            580                 585                 590         


Ser Thr Arg Arg Ser Gly Arg Ile Ser Ser Thr Pro Thr Thr Glu Thr 
        595                 600                 605             


Ile Arg Gly Ile Asp Ser Asp Asp Val Gln Asp Asn Ser Gln Leu Lys 
    610                 615                 620                 


Ala Ser Thr Gln Lys Ala Ala Asn Leu Ser Glu Lys His Ser Leu Tyr 
625                 630                 635                 640 


Thr Ala Glu Leu Ile Thr Val Pro Phe Asp Ser Glu Ser Pro Ile Arg 
                645                 650                 655     


Met Lys Phe Thr Arg Ile Ser Thr Pro Lys Lys Ser Lys Lys Lys Ser 
            660                 665                 670         


Asn Lys Arg Ser Glu Lys Ser Glu Ala Thr Asp Gly Gly Phe Thr Ser 
        675                 680                 685             


Gln Ile Arg Lys Ala Ser Asn Thr Ser Lys Asn Ile Ser Lys Ala Lys 
    690                 695                 700                 


Gln Leu Ile Glu Lys Ala Lys Ala Leu His Ile Ser Arg Ser Lys Val 
705                 710                 715                 720 


Thr Glu Glu Ile Ala Ile Pro Leu Arg Arg Ser Ser Arg His Gln Thr 
                725                 730                 735     


Leu Pro Glu Arg Lys Lys Leu Ser Glu Thr Glu Asp Ser Val Ile Ile 
            740                 745                 750         


Ile Asp Ser Ser Pro Thr Ala Leu Lys His Pro Glu Lys Asn Gln Lys 
        755                 760                 765             


Lys Leu Gln Cys Leu Asn Asp Val Leu Gly Lys Lys Leu Asn Thr Ser 
    770                 775                 780                 


Thr Lys Asn Val Pro Gly Lys Met Lys Val Ala Pro Leu Phe Leu Val 
785                 790                 795                 800 


Arg Lys Ala Gln Lys Ala Ala Asp Pro Val Pro Ser Phe Asp Glu Ser 
                805                 810                 815     


Ser Gln Asp Thr Ser Glu Lys Ser Gln Asp Cys Asp Val Gln Cys Lys 
            820                 825                 830         


Ala Lys Arg Asp Phe Leu Met Ser Gly Leu Pro Asp Leu Leu Lys Arg 
        835                 840                 845             


Gln Ile Ala Lys Lys Ala Ala Ala Leu Asp Val Tyr Asn Ala Val Ser 
    850                 855                 860                 


Thr Ser Phe Gln Arg Val Val His Val Gln Gln Lys Asp Asp Gly Cys 
865                 870                 875                 880 


Cys Leu Trp His Leu Lys Pro Pro Ser Cys Pro Leu Leu Thr Lys Phe 
                885                 890                 895     


Lys Glu Leu Asn Thr Lys Val Ile Asp Leu Ser Lys Cys Gly Ile Ala 
            900                 905                 910         


Leu Gly Glu Phe Ser Thr Leu Asn Ser Lys Leu Lys Ser Gly Asn Ser 
        915                 920                 925             


Ala Ala Val Phe Met Arg Thr Arg Lys Glu Phe Thr Glu Glu Val Arg 
    930                 935                 940                 


Asn Leu Leu Leu Glu Glu Ile Arg Trp Ser Asn Pro Glu Phe Ser Leu 
945                 950                 955                 960 


Lys Lys Tyr Phe Pro Leu Leu Leu Lys Lys Gln Ile Glu His Gln Val 
                965                 970                 975     


Leu Ser Ser Glu Cys His Ser Lys Gln Glu Leu Glu Ala Asp Val Ser 
            980                 985                 990         


His Lys Glu Thr Lys Arg Lys Leu  Val Glu Ala Glu Asn  Ser Lys Ser 
        995                 1000                 1005             


Lys Arg  Lys Lys Pro Asn Glu  Tyr Ser Lys Asn Leu  Glu Lys Thr 
    1010                 1015                 1020             


Asn Arg  Lys Ser Glu Glu Leu  Ser Lys Arg Asn Asn  Ser Ser Gly 
    1025                 1030                 1035             


Ile Lys  Leu Asp Ser Ser Lys  Asp Ser Gly Thr Glu  Asp Met Leu 
    1040                 1045                 1050             


Trp Thr  Glu Lys Tyr Gln Pro  Gln Thr Ala Ser Glu  Leu Ile Gly 
    1055                 1060                 1065             


Asn Glu  Leu Ala Ile Lys Lys  Leu His Ser Trp Leu  Lys Asp Trp 
    1070                 1075                 1080             


Lys Arg  Arg Ala Glu Leu Glu  Glu Arg Gln Asn Leu  Lys Gly Lys 
    1085                 1090                 1095             


Arg Asp  Glu Lys His Glu Asp  Phe Ser Gly Gly Ile  Asp Phe Lys 
    1100                 1105                 1110             


Gly Ser  Ser Asp Asp Glu Glu  Glu Ser Arg Leu Cys  Asn Thr Val 
    1115                 1120                 1125             


Leu Ile  Thr Gly Pro Thr Gly  Val Gly Lys Thr Ala  Ala Val Tyr 
    1130                 1135                 1140             


Ala Cys  Ala Gln Glu Leu Gly  Phe Lys Ile Phe Glu  Val Asn Ala 
    1145                 1150                 1155             


Ser Ser  Gln Arg Ser Gly Arg  Gln Ile Leu Ser Gln  Leu Lys Glu 
    1160                 1165                 1170             


Ala Thr  Gln Ser His Gln Val  Asp Lys Gln Gly Val  Asn Ser Gln 
    1175                 1180                 1185             


Lys Pro  Cys Phe Phe Asn Ser  Tyr Tyr Ile Gly Lys  Ser Pro Lys 
    1190                 1195                 1200             


Lys Ile  Ser Ser Pro Lys Lys  Val Val Thr Ser Pro  Arg Lys Val 
    1205                 1210                 1215             


Pro Pro  Pro Ser Pro Lys Ser  Ser Gly Pro Lys Arg  Ala Leu Pro 
    1220                 1225                 1230             


Pro Lys  Thr Leu Ala Asn Tyr  Phe Lys Val Ser Pro  Lys Pro Lys 
    1235                 1240                 1245             


Asn Asn  Glu Glu Ile Gly Met  Leu Leu Glu Asn Asn  Lys Gly Ile 
    1250                 1255                 1260             


Lys Asn  Ser Phe Glu Gln Lys  Gln Ile Thr Gln Thr  Lys Ser Thr 
    1265                 1270                 1275             


Asn Ala  Thr Asn Ser Asn Val  Lys Asp Val Gly Ala  Glu Glu Pro 
    1280                 1285                 1290             


Ser Arg  Lys Asn Ala Thr Ser  Leu Ile Leu Phe Glu  Glu Val Asp 
    1295                 1300                 1305             


Val Ile  Phe Asp Glu Asp Ala  Gly Phe Leu Asn Ala  Ile Lys Thr 
    1310                 1315                 1320             


Phe Met  Ala Thr Thr Lys Arg  Pro Val Ile Leu Thr  Thr Ser Asp 
    1325                 1330                 1335             


Pro Thr  Phe Ser Leu Met Phe  Asp Gly Cys Phe Glu  Glu Ile Lys 
    1340                 1345                 1350             


Phe Ser  Thr Pro Ser Leu Leu  Asn Val Ala Ser Tyr  Leu Gln Met 
    1355                 1360                 1365             


Ile Cys  Leu Thr Glu Asn Phe  Arg Thr Asp Val Lys  Asp Phe Val 
    1370                 1375                 1380             


Thr Leu  Leu Thr Ala Asn Thr  Cys Asp Ile Arg Lys  Ser Ile Leu 
    1385                 1390                 1395             


Tyr Leu  Gln Phe Trp Ile Arg  Ser Gly Gly Gly Val  Leu Glu Glu 
    1400                 1405                 1410             


Arg Pro  Leu Thr Leu Tyr Arg  Gly Asn Ser Arg Asn  Val Gln Leu 
    1415                 1420                 1425             


Val Cys  Ser Glu His Gly Leu  Asp Asn Lys Ile Tyr  Pro Lys Asn 
    1430                 1435                 1440             


Thr Lys  Lys Lys Arg Val Asp  Leu Pro Lys Cys Asp  Ser Gly Cys 
    1445                 1450                 1455             


Ala Glu  Thr Leu Phe Gly Leu  Lys Asn Ile Phe Ser  Pro Ser Glu 
    1460                 1465                 1470             


Asp Leu  Phe Ser Phe Leu Lys  His Lys Ile Thr Met  Lys Glu Glu 
    1475                 1480                 1485             


Trp His  Lys Phe Ile Gln Leu  Leu Thr Glu Phe Gln  Met Arg Asn 
    1490                 1495                 1500             


Val Asp  Phe Leu Tyr Ser Asn  Leu Glu Phe Ile Leu  Pro Leu Pro 
    1505                 1510                 1515             


Val Asp  Thr Ile Pro Glu Thr  Lys Asn Phe Cys Gly  Pro Ser Val 
    1520                 1525                 1530             


Thr Val  Asp Ala Ser Ala Ala  Thr Lys Ser Met Asn  Cys Leu Ala 
    1535                 1540                 1545             


Arg Lys  His Ser Glu Arg Glu  Gln Pro Leu Lys Lys  Ser Gln Lys 
    1550                 1555                 1560             


Lys Lys  Gln Lys Lys Thr Leu  Val Ile Leu Asp Asp  Ser Asp Leu 
    1565                 1570                 1575             


Phe Asp  Thr Asp Leu Asp Phe  Pro Asp Gln Ser Ile  Ser Leu Ser 
    1580                 1585                 1590             


Ser Val  Ser Ser Ser Ser Asn  Ala Glu Glu Ser Lys  Thr Gly Asp 
    1595                 1600                 1605             


Glu Glu  Ser Lys Ala Arg Asp  Lys Gly Asn Asn Pro  Glu Thr Lys 
    1610                 1615                 1620             


Lys Ser  Ile Pro Cys Pro Pro  Lys Thr Thr Ala Gly  Lys Lys Cys 
    1625                 1630                 1635             


Ser Ala  Leu Val Ser His Cys  Leu Asn Ser Leu Ser  Glu Phe Met 
    1640                 1645                 1650             


Asp Asn  Met Ser Phe Leu Asp  Ala Leu Leu Thr Asp  Val Arg Glu 
    1655                 1660                 1665             


Gln Asn  Lys Tyr Gly Arg Asn  Asp Phe Ser Trp Thr  Asn Gly Lys 
    1670                 1675                 1680             


Val Thr  Ser Gly Leu Cys Asp  Glu Phe Ser Leu Glu  Ser Asn Asp 
    1685                 1690                 1695             


Gly Trp  Thr Ser Gln Ser Ser  Gly Glu Leu Lys Ala  Ala Ala Glu 
    1700                 1705                 1710             


Ala Leu  Ser Phe Thr Lys Cys  Ser Ser Ala Ile Ser  Lys Ala Leu 
    1715                 1720                 1725             


Glu Thr  Leu Asn Ser Cys Lys  Lys Leu Gly Arg Asp  Pro Thr Asn 
    1730                 1735                 1740             


Asp Leu  Thr Phe Tyr Val Ser  Gln Lys Arg Asn Asn  Val Tyr Phe 
    1745                 1750                 1755             


Ser Gln  Ser Ala Ala Asn Leu  Asp Asn Ala Trp Lys  Arg Ile Ser 
    1760                 1765                 1770             


Val Ile  Lys Ser Val Phe Ser  Ser Arg Ser Leu Leu  Tyr Val Gly 
    1775                 1780                 1785             


Asn Arg  Gln Ala Ser Ile Ile  Glu Tyr Leu Pro Thr  Leu Arg Asn 
    1790                 1795                 1800             


Ile Cys  Lys Thr Glu Lys Leu  Lys Glu Gln Gly Lys  Ser Lys Arg 
    1805                 1810                 1815             


Arg Phe  Leu His Tyr Phe Glu  Gly Ile His Leu Asp  Ile Pro Lys 
    1820                 1825                 1830             


Glu Thr  Val Asn Thr Leu Ala  Ala Asp Phe Pro 
    1835                 1840                 


<210>  1209
<211>  1224
<212>  PRT
<213>  Homo Sapiens

<400>  1209

Met Val Gly Val Leu Ala Met Ala Ala Ala Ala Ala Pro Pro Pro Val 
1               5                   10                  15      


Lys Asp Cys Glu Ile Glu Pro Cys Lys Lys Arg Lys Lys Asp Asp Asp 
            20                  25                  30          


Thr Ser Thr Cys Lys Thr Ile Thr Lys Tyr Leu Ser Pro Leu Gly Lys 
        35                  40                  45              


Thr Arg Asp Arg Val Phe Ala Pro Pro Lys Pro Ser Asn Ile Leu Asp 
    50                  55                  60                  


Tyr Phe Arg Lys Thr Ser Pro Thr Asn Glu Lys Thr Gln Leu Gly Lys 
65                  70                  75                  80  


Glu Cys Lys Ile Lys Ser Pro Glu Ser Val Pro Val Asp Ser Asn Lys 
                85                  90                  95      


Asp Cys Thr Thr Pro Leu Glu Met Phe Ser Asn Val Glu Phe Lys Lys 
            100                 105                 110         


Lys Arg Lys Arg Val Asn Leu Ser His Gln Leu Asn Asn Ile Lys Thr 
        115                 120                 125             


Glu Asn Glu Ala Pro Ile Glu Ile Ser Ser Asp Asp Ser Lys Glu Asp 
    130                 135                 140                 


Tyr Ser Leu Asn Asn Asp Phe Val Glu Ser Ser Thr Ser Val Leu Arg 
145                 150                 155                 160 


Tyr Lys Lys Gln Val Glu Val Leu Ala Glu Asn Ile Gln Asp Thr Lys 
                165                 170                 175     


Ser Gln Pro Asn Thr Met Thr Ser Leu Gln Asn Ser Lys Lys Val Asn 
            180                 185                 190         


Pro Lys Gln Gly Thr Thr Lys Asn Asp Phe Lys Lys Leu Arg Lys Arg 
        195                 200                 205             


Lys Cys Arg Asp Val Val Asp Leu Ser Glu Ser Leu Pro Leu Ala Glu 
    210                 215                 220                 


Glu Leu Asn Leu Leu Lys Lys Asp Gly Lys Asp Thr Lys Gln Met Glu 
225                 230                 235                 240 


Asn Thr Thr Ser His Ala Asn Ser Arg Asp Asn Val Thr Glu Ala Ala 
                245                 250                 255     


Gln Leu Asn Asp Ser Ile Ile Thr Val Ser Tyr Glu Glu Phe Leu Lys 
            260                 265                 270         


Ser His Lys Glu Asn Lys Val Glu Glu Ile Pro Asp Ser Thr Met Ser 
        275                 280                 285             


Ile Cys Val Pro Ser Glu Thr Val Asp Glu Ile Val Lys Ser Gly Tyr 
    290                 295                 300                 


Ile Ser Glu Ser Glu Asn Ser Glu Ile Ser Gln Gln Val Arg Phe Lys 
305                 310                 315                 320 


Thr Val Thr Val Leu Ala Gln Val His Pro Ile Pro Pro Lys Lys Thr 
                325                 330                 335     


Gly Lys Ile Pro Arg Ile Phe Leu Lys Gln Lys Gln Phe Glu Met Glu 
            340                 345                 350         


Asn Ser Leu Ser Asp Pro Glu Asn Glu Gln Thr Val Gln Lys Arg Lys 
        355                 360                 365             


Ser Asn Val Val Ile Gln Glu Glu Glu Leu Glu Leu Ala Val Leu Glu 
    370                 375                 380                 


Ala Gly Ser Ser Glu Ala Val Lys Pro Lys Cys Thr Leu Glu Glu Arg 
385                 390                 395                 400 


Gln Gln Phe Met Lys Ala Phe Arg Gln Pro Ala Ser Asp Ala Leu Lys 
                405                 410                 415     


Asn Gly Val Lys Lys Ser Ser Asp Lys Gln Lys Asp Leu Asn Glu Lys 
            420                 425                 430         


Cys Leu Tyr Glu Val Gly Arg Asp Asp Asn Ser Lys Lys Ile Met Glu 
        435                 440                 445             


Asn Ser Gly Ile Gln Met Val Ser Lys Asn Gly Asn Leu Gln Leu His 
    450                 455                 460                 


Thr Asp Lys Gly Ser Phe Leu Lys Glu Lys Asn Lys Lys Leu Lys Lys 
465                 470                 475                 480 


Lys Asn Lys Lys Thr Leu Asp Thr Gly Ala Ile Pro Gly Lys Asn Arg 
                485                 490                 495     


Glu Gly Asn Thr Gln Lys Lys Glu Thr Thr Phe Phe Leu Lys Glu Lys 
            500                 505                 510         


Gln Tyr Gln Asn Arg Met Ser Leu Arg Gln Arg Lys Thr Glu Phe Phe 
        515                 520                 525             


Lys Ser Ser Thr Leu Phe Asn Asn Glu Ser Leu Val Tyr Glu Asp Ile 
    530                 535                 540                 


Ala Asn Asp Asp Leu Leu Lys Val Ser Ser Leu Cys Asn Asn Asn Lys 
545                 550                 555                 560 


Leu Ser Arg Lys Thr Ser Ile Pro Val Lys Asp Ile Lys Leu Thr Gln 
                565                 570                 575     


Ser Lys Ala Glu Ser Glu Ala Ser Leu Leu Asn Val Ser Thr Pro Lys 
            580                 585                 590         


Ser Thr Arg Arg Ser Gly Arg Ile Ser Ser Thr Pro Thr Thr Glu Thr 
        595                 600                 605             


Ile Arg Gly Ile Asp Ser Asp Asp Val Gln Asp Asn Ser Gln Leu Lys 
    610                 615                 620                 


Ala Ser Thr Gln Lys Ala Ala Asn Leu Ser Glu Lys His Ser Leu Tyr 
625                 630                 635                 640 


Thr Ala Glu Leu Ile Thr Val Pro Phe Asp Ser Glu Ser Pro Ile Arg 
                645                 650                 655     


Met Lys Phe Thr Arg Ile Ser Thr Pro Lys Lys Ser Lys Lys Lys Ser 
            660                 665                 670         


Asn Lys Arg Ser Glu Lys Ser Glu Ala Thr Asp Gly Gly Phe Thr Ser 
        675                 680                 685             


Gln Ile Arg Lys Ala Ser Asn Thr Ser Lys Asn Ile Ser Lys Ala Lys 
    690                 695                 700                 


Gln Leu Ile Glu Lys Ala Lys Ala Leu His Ile Ser Arg Ser Lys Val 
705                 710                 715                 720 


Thr Glu Glu Ile Ala Ile Pro Leu Arg Arg Ser Ser Arg His Gln Thr 
                725                 730                 735     


Leu Pro Glu Arg Lys Lys Leu Ser Glu Thr Glu Asp Ser Val Ile Ile 
            740                 745                 750         


Ile Asp Ser Ser Pro Thr Ala Leu Lys His Pro Glu Lys Asn Gln Lys 
        755                 760                 765             


Lys Leu Gln Cys Leu Asn Asp Val Leu Gly Lys Lys Leu Asn Thr Ser 
    770                 775                 780                 


Thr Lys Asn Val Pro Gly Lys Met Lys Val Ala Pro Leu Phe Leu Val 
785                 790                 795                 800 


Arg Lys Ala Gln Lys Ala Ala Asp Pro Val Pro Ser Phe Asp Glu Ser 
                805                 810                 815     


Ser Gln Asp Thr Ser Glu Lys Ser Gln Asp Cys Asp Val Gln Cys Lys 
            820                 825                 830         


Ala Lys Arg Asp Phe Leu Met Ser Gly Leu Pro Asp Leu Leu Lys Arg 
        835                 840                 845             


Gln Ile Ala Lys Lys Ala Ala Ala Leu Asp Val Tyr Asn Ala Val Ser 
    850                 855                 860                 


Thr Ser Phe Gln Arg Val Val His Val Gln Gln Lys Asp Asp Gly Cys 
865                 870                 875                 880 


Cys Leu Trp His Leu Lys Pro Pro Ser Cys Pro Leu Leu Thr Lys Phe 
                885                 890                 895     


Lys Glu Leu Asn Thr Lys Val Ile Asp Leu Ser Lys Cys Gly Ile Ala 
            900                 905                 910         


Leu Gly Glu Phe Ser Thr Leu Asn Ser Lys Leu Lys Ser Gly Asn Ser 
        915                 920                 925             


Ala Ala Val Phe Met Arg Thr Arg Lys Glu Phe Thr Glu Glu Val Arg 
    930                 935                 940                 


Asn Leu Leu Leu Glu Glu Ile Arg Trp Ser Asn Pro Glu Phe Ser Leu 
945                 950                 955                 960 


Lys Lys Tyr Phe Pro Leu Leu Leu Lys Lys Gln Ile Glu His Gln Val 
                965                 970                 975     


Leu Ser Ser Glu Cys His Ser Lys Gln Glu Leu Glu Ala Asp Val Ser 
            980                 985                 990         


His Lys Glu Thr Lys Arg Lys Leu  Val Glu Ala Glu Asn  Ser Lys Ser 
        995                 1000                 1005             


Lys Arg  Lys Lys Pro Asn Glu  Tyr Ser Lys Asn Leu  Glu Lys Thr 
    1010                 1015                 1020             


Asn Arg  Lys Ser Glu Glu Leu  Ser Lys Arg Asn Asn  Ser Ser Gly 
    1025                 1030                 1035             


Ile Lys  Leu Asp Ser Ser Lys  Asp Ser Gly Thr Glu  Asp Met Leu 
    1040                 1045                 1050             


Trp Thr  Glu Lys Tyr Gln Pro  Gln Thr Ala Ser Glu  Leu Ile Gly 
    1055                 1060                 1065             


Asn Glu  Leu Ala Ile Lys Lys  Leu His Ser Trp Leu  Lys Asp Trp 
    1070                 1075                 1080             


Lys Arg  Arg Ala Glu Leu Glu  Glu Arg Gln Asn Leu  Lys Gly Lys 
    1085                 1090                 1095             


Arg Asp  Glu Lys His Glu Asp  Phe Ser Gly Gly Ile  Asp Phe Lys 
    1100                 1105                 1110             


Gly Ser  Ser Asp Asp Glu Glu  Glu Ser Arg Leu Cys  Asn Thr Val 
    1115                 1120                 1125             


Leu Ile  Thr Gly Pro Thr Gly  Val Gly Lys Thr Ala  Ala Val Tyr 
    1130                 1135                 1140             


Ala Cys  Ala Gln Glu Leu Gly  Phe Lys Ile Phe Glu  Val Asn Ala 
    1145                 1150                 1155             


Ser Ser  Gln Arg Ser Gly Arg  Gln Ile Leu Ser Gln  Leu Lys Glu 
    1160                 1165                 1170             


Ala Thr  Gln Ser His Gln Val  Asp Lys Gln Gly Val  Asn Ser Gln 
    1175                 1180                 1185             


Lys Pro  Cys Phe Phe Asn Ser  Tyr Tyr Ile Gly Lys  Ser Pro Lys 
    1190                 1195                 1200             


Lys Ile  Ser Ser Pro Lys Lys  Val Val Thr Ser Pro  Arg Lys Val 
    1205                 1210                 1215             


Pro Pro  Pro Ser Pro Lys 
    1220                 


<210>  1210
<211>  310
<212>  PRT
<213>  Homo Sapiens

<400>  1210

Met Glu Phe Pro Phe Asp Val Asp Ala Leu Phe Pro Glu Arg Ile Thr 
1               5                   10                  15      


Val Leu Asp Gln His Leu Arg Pro Pro Ala Arg Arg Pro Gly Thr Thr 
            20                  25                  30          


Thr Pro Ala Arg Val Asp Leu Gln Gln Gln Ile Met Thr Ile Ile Asp 
        35                  40                  45              


Glu Leu Gly Lys Ala Ser Ala Lys Ala Gln Asn Leu Ser Ala Pro Ile 
    50                  55                  60                  


Thr Ser Ala Ser Arg Met Gln Ser Asn Arg His Val Val Tyr Ile Leu 
65                  70                  75                  80  


Lys Asp Ser Ser Ala Arg Pro Ala Gly Lys Gly Ala Ile Ile Gly Phe 
                85                  90                  95      


Ile Lys Val Gly Tyr Lys Lys Leu Phe Val Leu Asp Asp Arg Glu Ala 
            100                 105                 110         


His Asn Glu Val Glu Pro Leu Cys Ile Leu Asp Phe Tyr Ile His Glu 
        115                 120                 125             


Ser Val Gln Arg His Gly His Gly Arg Glu Leu Phe Gln Tyr Met Leu 
    130                 135                 140                 


Gln Lys Glu Arg Val Glu Pro His Gln Leu Ala Ile Asp Arg Pro Ser 
145                 150                 155                 160 


Gln Lys Leu Leu Lys Phe Leu Asn Lys His Tyr Asn Leu Glu Thr Thr 
                165                 170                 175     


Val Pro Gln Val Asn Asn Phe Val Ile Phe Glu Gly Phe Phe Ala His 
            180                 185                 190         


Gln His Pro Pro Ala Arg Lys Leu Pro Pro Lys Arg Ala Glu Gly Asp 
        195                 200                 205             


Ile Lys Pro Tyr Ser Ser Ser Asp Arg Glu Phe Leu Lys Val Ala Val 
    210                 215                 220                 


Glu Pro Pro Trp Pro Leu Asn Arg Ala Pro Arg Arg Ala Thr Pro Pro 
225                 230                 235                 240 


Ala His Pro Pro Pro Arg Ser Ser Ser Leu Gly Asn Ser Pro Glu Arg 
                245                 250                 255     


Gly Pro Leu Arg Pro Phe Val Pro Glu Gln Glu Leu Leu Arg Ser Leu 
            260                 265                 270         


Arg Leu Cys Pro Pro His Pro Thr Ala Arg Leu Leu Leu Ala Ala Asp 
        275                 280                 285             


Pro Gly Gly Ser Pro Ala Gln Arg Arg Arg Thr Ser Ser Leu Pro Arg 
    290                 295                 300                 


Ser Glu Glu Ser Arg Tyr 
305                 310 


<210>  1211
<211>  300
<212>  PRT
<213>  Homo Sapiens

<400>  1211

Met Glu Phe Pro Phe Asp Val Asp Ala Leu Phe Pro Glu Arg Ile Thr 
1               5                   10                  15      


Val Leu Asp Gln His Leu Arg Pro Pro Ala Arg Arg Pro Gly Thr Thr 
            20                  25                  30          


Thr Pro Ala Arg Val Asp Leu Gln Gln Gln Ile Met Thr Ile Ile Asp 
        35                  40                  45              


Glu Leu Gly Lys Ala Ser Ala Lys Ala Gln Asn Leu Ser Ala Pro Ile 
    50                  55                  60                  


Thr Ser Ala Ser Arg Met Gln Ser Asn Arg His Val Val Tyr Ile Leu 
65                  70                  75                  80  


Lys Asp Ser Ser Ala Arg Pro Ala Gly Lys Gly Ala Ile Ile Gly Phe 
                85                  90                  95      


Ile Lys Val Gly Tyr Lys Lys Leu Phe Val Leu Asp Asp Arg Glu Ala 
            100                 105                 110         


His Asn Glu Val Glu Pro Leu Cys Ile Leu Asp Phe Tyr Ile His Glu 
        115                 120                 125             


Ser Val Gln Arg His Gly His Gly Arg Glu Leu Phe Gln Tyr Met Leu 
    130                 135                 140                 


Gln Lys Glu Arg Val Glu Pro His Gln Leu Ala Ile Asp Arg Pro Ser 
145                 150                 155                 160 


Gln Lys Leu Leu Lys Phe Leu Asn Lys His Tyr Asn Leu Glu Thr Thr 
                165                 170                 175     


Val Pro Gln Val Asn Asn Phe Val Ile Phe Glu Gly Phe Phe Ala His 
            180                 185                 190         


Gln His Pro Pro Ala Arg Lys Leu Pro Pro Lys Arg Ala Glu Gly Asp 
        195                 200                 205             


Ile Lys Pro Tyr Ser Ser Ser Asp Arg Glu Phe Leu Lys Val Ala Val 
    210                 215                 220                 


Glu Pro Pro Trp Pro Leu Asn Arg Ala Pro Arg Arg Ala Thr Pro Pro 
225                 230                 235                 240 


Ala His Pro Pro Pro Arg Ser Ser Ser Leu Gly Asn Ser Pro Glu Arg 
                245                 250                 255     


Gly Pro Leu Arg Pro Phe Val Pro Glu Gln Glu Leu Leu Arg Ser Leu 
            260                 265                 270         


Arg Leu Cys Pro Pro His Pro Thr Ala Arg Leu Leu Leu Ala Ala Asp 
        275                 280                 285             


Pro Gly Gly Ser Pro Ala Gln Arg Arg Arg Thr Arg 
    290                 295                 300 


<210>  1212
<211>  333
<212>  PRT
<213>  Homo Sapiens

<400>  1212

Met Glu Phe Pro Phe Asp Val Asp Ala Leu Phe Pro Glu Arg Ile Thr 
1               5                   10                  15      


Val Leu Asp Gln His Leu Arg Pro Pro Ala Arg Arg Pro Gly Thr Thr 
            20                  25                  30          


Thr Pro Ala Arg Val Asp Leu Gln Gln Gln Ile Met Thr Ile Ile Asp 
        35                  40                  45              


Glu Leu Gly Lys Ala Ser Ala Lys Ala Gln Asn Leu Ser Ala Pro Ile 
    50                  55                  60                  


Thr Ser Ala Ser Arg Met Gln Ser Asn Arg His Val Val Tyr Ile Leu 
65                  70                  75                  80  


Lys Asp Ser Ser Ala Arg Pro Ala Gly Lys Gly Ala Ile Ile Gly Phe 
                85                  90                  95      


Ile Lys Val Gly Tyr Lys Lys Leu Phe Val Leu Asp Asp Arg Glu Ala 
            100                 105                 110         


His Asn Glu Val Glu Pro Leu Cys Ile Leu Asp Phe Tyr Ile His Glu 
        115                 120                 125             


Ser Val Gln Arg His Gly His Gly Arg Glu Leu Phe Gln Tyr Met Leu 
    130                 135                 140                 


Gln Lys Glu Arg Val Glu Pro His Gln Leu Ala Ile Asp Arg Pro Ser 
145                 150                 155                 160 


Gln Lys Leu Leu Lys Phe Leu Asn Lys His Tyr Asn Leu Glu Thr Thr 
                165                 170                 175     


Val Pro Gln Val Asn Asn Phe Val Ile Phe Glu Gly Phe Phe Ala His 
            180                 185                 190         


Gln His Arg Pro Pro Ala Pro Ser Leu Arg Ala Thr Arg His Ser Arg 
        195                 200                 205             


Ala Ala Ala Val Asp Pro Thr Pro Ala Ala Pro Ala Arg Lys Leu Pro 
    210                 215                 220                 


Pro Lys Arg Ala Glu Gly Asp Ile Lys Pro Tyr Ser Ser Ser Asp Arg 
225                 230                 235                 240 


Glu Phe Leu Lys Val Ala Val Glu Pro Pro Trp Pro Leu Asn Arg Ala 
                245                 250                 255     


Pro Arg Arg Ala Thr Pro Pro Ala His Pro Pro Pro Arg Ser Ser Ser 
            260                 265                 270         


Leu Gly Asn Ser Pro Glu Arg Gly Pro Leu Arg Pro Phe Val Pro Glu 
        275                 280                 285             


Gln Glu Leu Leu Arg Ser Leu Arg Leu Cys Pro Pro His Pro Thr Ala 
    290                 295                 300                 


Arg Leu Leu Leu Ala Ala Asp Pro Gly Gly Ser Pro Ala Gln Arg Arg 
305                 310                 315                 320 


Arg Thr Ser Ser Leu Pro Arg Ser Glu Glu Ser Arg Tyr 
                325                 330             


<210>  1213
<211>  421
<212>  PRT
<213>  Homo Sapiens

<400>  1213

Met Glu Phe Pro Phe Asp Val Asp Ala Leu Phe Pro Glu Arg Ile Thr 
1               5                   10                  15      


Val Leu Asp Gln His Leu Arg Pro Pro Ala Arg Arg Pro Gly Thr Thr 
            20                  25                  30          


Thr Pro Ala Arg Val Asp Leu Gln Gln Gln Ile Met Thr Ile Ile Asp 
        35                  40                  45              


Glu Leu Gly Lys Ala Ser Ala Lys Ala Gln Asn Leu Ser Ala Pro Ile 
    50                  55                  60                  


Thr Ser Ala Ser Arg Met Gln Ser Asn Arg His Val Val Tyr Ile Leu 
65                  70                  75                  80  


Lys Asp Ser Ser Ala Arg Pro Ala Gly Lys Gly Ala Ile Ile Gly Phe 
                85                  90                  95      


Ile Lys Val Gly Tyr Lys Lys Leu Phe Val Leu Asp Asp Arg Glu Ala 
            100                 105                 110         


His Asn Glu Val Glu Pro Leu Cys Ile Leu Asp Phe Tyr Ile His Glu 
        115                 120                 125             


Ser Val Gln Arg His Gly His Gly Arg Glu Leu Phe Gln Tyr Met Leu 
    130                 135                 140                 


Gln Lys Glu Arg Val Glu Pro His Gln Leu Ala Ile Asp Arg Pro Ser 
145                 150                 155                 160 


Gln Lys Leu Leu Lys Phe Leu Asn Lys His Tyr Asn Leu Glu Thr Thr 
                165                 170                 175     


Val Pro Gln Val Asn Asn Phe Val Ile Phe Glu Gly Phe Phe Ala His 
            180                 185                 190         


Gln His Arg Pro Pro Ala Pro Ser Leu Arg Ala Thr Arg His Ser Arg 
        195                 200                 205             


Ala Ala Ala Val Asp Pro Thr Pro Ala Ala Pro Ala Arg Lys Leu Pro 
    210                 215                 220                 


Pro Lys Arg Ala Glu Gly Asp Ile Lys Pro Tyr Ser Ser Ser Asp Arg 
225                 230                 235                 240 


Glu Phe Leu Lys Val Ala Val Glu Pro Pro Trp Pro Leu Asn Arg Ala 
                245                 250                 255     


Pro Arg Arg Ala Thr Pro Pro Ala His Pro Pro Pro Arg Ser Ser Ser 
            260                 265                 270         


Leu Gly Asn Ser Pro Glu Arg Gly Pro Leu Arg Pro Phe Val Pro Glu 
        275                 280                 285             


Gln Glu Leu Leu Arg Ser Leu Arg Leu Cys Pro Pro His Pro Thr Ala 
    290                 295                 300                 


Arg Leu Leu Leu Ala Ala Asp Pro Gly Gly Ser Pro Ala Gln Arg Arg 
305                 310                 315                 320 


Arg Thr Arg Gly Thr Pro Pro Gly Leu Val Ala Gln Ser Cys Cys Tyr 
                325                 330                 335     


Ser Arg His Gly Gly Val Asn Ser Ser Ser Pro Asn Thr Gly Asn Gln 
            340                 345                 350         


Asp Ser Lys Gln Gly Glu Gln Glu Thr Lys Asn Arg Ser Ala Ser Glu 
        355                 360                 365             


Glu Gln Ala Leu Ser Gln Asp Gly Ser Gly Glu Lys Pro Met His Thr 
    370                 375                 380                 


Ala Pro Pro Gln Ala Pro Ala Pro Pro Ala Gln Ser Trp Thr Val Gly 
385                 390                 395                 400 


Gly Asp Ile Leu Asn Ala Arg Phe Ile Arg Asn Leu Gln Glu Arg Arg 
                405                 410                 415     


Ser Thr Arg Pro Trp 
            420     


<210>  1214
<211>  323
<212>  PRT
<213>  Homo Sapiens

<400>  1214

Met Glu Phe Pro Phe Asp Val Asp Ala Leu Phe Pro Glu Arg Ile Thr 
1               5                   10                  15      


Val Leu Asp Gln His Leu Arg Pro Pro Ala Arg Arg Pro Gly Thr Thr 
            20                  25                  30          


Thr Pro Ala Arg Val Asp Leu Gln Gln Gln Ile Met Thr Ile Ile Asp 
        35                  40                  45              


Glu Leu Gly Lys Ala Ser Ala Lys Ala Gln Asn Leu Ser Ala Pro Ile 
    50                  55                  60                  


Thr Ser Ala Ser Arg Met Gln Ser Asn Arg His Val Val Tyr Ile Leu 
65                  70                  75                  80  


Lys Asp Ser Ser Ala Arg Pro Ala Gly Lys Gly Ala Ile Ile Gly Phe 
                85                  90                  95      


Ile Lys Val Gly Tyr Lys Lys Leu Phe Val Leu Asp Asp Arg Glu Ala 
            100                 105                 110         


His Asn Glu Val Glu Pro Leu Cys Ile Leu Asp Phe Tyr Ile His Glu 
        115                 120                 125             


Ser Val Gln Arg His Gly His Gly Arg Glu Leu Phe Gln Tyr Met Leu 
    130                 135                 140                 


Gln Lys Glu Arg Val Glu Pro His Gln Leu Ala Ile Asp Arg Pro Ser 
145                 150                 155                 160 


Gln Lys Leu Leu Lys Phe Leu Asn Lys His Tyr Asn Leu Glu Thr Thr 
                165                 170                 175     


Val Pro Gln Val Asn Asn Phe Val Ile Phe Glu Gly Phe Phe Ala His 
            180                 185                 190         


Gln His Arg Pro Pro Ala Pro Ser Leu Arg Ala Thr Arg His Ser Arg 
        195                 200                 205             


Ala Ala Ala Val Asp Pro Thr Pro Ala Ala Pro Ala Arg Lys Leu Pro 
    210                 215                 220                 


Pro Lys Arg Ala Glu Gly Asp Ile Lys Pro Tyr Ser Ser Ser Asp Arg 
225                 230                 235                 240 


Glu Phe Leu Lys Val Ala Val Glu Pro Pro Trp Pro Leu Asn Arg Ala 
                245                 250                 255     


Pro Arg Arg Ala Thr Pro Pro Ala His Pro Pro Pro Arg Ser Ser Ser 
            260                 265                 270         


Leu Gly Asn Ser Pro Glu Arg Gly Pro Leu Arg Pro Phe Val Pro Glu 
        275                 280                 285             


Gln Glu Leu Leu Arg Ser Leu Arg Leu Cys Pro Pro His Pro Thr Ala 
    290                 295                 300                 


Arg Leu Leu Leu Ala Ala Asp Pro Gly Gly Ser Pro Ala Gln Arg Arg 
305                 310                 315                 320 


Arg Thr Arg 
            


<210>  1215
<211>  409
<212>  PRT
<213>  Homo Sapiens

<400>  1215

Met Trp Leu Thr Trp Pro Phe Cys Phe Leu Thr Ile Thr Leu Arg Glu 
1               5                   10                  15      


Glu Gly Val Cys His Leu Glu Ser Val Asp Leu Gln Gln Gln Ile Met 
            20                  25                  30          


Thr Ile Ile Asp Glu Leu Gly Lys Ala Ser Ala Lys Ala Gln Asn Leu 
        35                  40                  45              


Ser Ala Pro Ile Thr Ser Ala Ser Arg Met Gln Ser Asn Arg His Val 
    50                  55                  60                  


Val Tyr Ile Leu Lys Asp Ser Ser Ala Arg Pro Ala Gly Lys Gly Ala 
65                  70                  75                  80  


Ile Ile Gly Phe Ile Lys Val Gly Tyr Lys Lys Leu Phe Val Leu Asp 
                85                  90                  95      


Asp Arg Glu Ala His Asn Glu Val Glu Pro Leu Cys Ile Leu Asp Phe 
            100                 105                 110         


Tyr Ile His Glu Ser Val Gln Arg His Gly His Gly Arg Glu Leu Phe 
        115                 120                 125             


Gln Tyr Met Leu Gln Lys Glu Arg Val Glu Pro His Gln Leu Ala Ile 
    130                 135                 140                 


Asp Arg Pro Ser Gln Lys Leu Leu Lys Phe Leu Asn Lys His Tyr Asn 
145                 150                 155                 160 


Leu Glu Thr Thr Val Pro Gln Val Asn Asn Phe Val Ile Phe Glu Gly 
                165                 170                 175     


Phe Phe Ala His Gln His Arg Pro Pro Ala Pro Ser Leu Arg Ala Thr 
            180                 185                 190         


Arg His Ser Arg Ala Ala Ala Val Asp Pro Thr Pro Ala Ala Pro Ala 
        195                 200                 205             


Arg Lys Leu Pro Pro Lys Arg Ala Glu Gly Asp Ile Lys Pro Tyr Ser 
    210                 215                 220                 


Ser Ser Asp Arg Glu Phe Leu Lys Val Ala Val Glu Pro Pro Trp Pro 
225                 230                 235                 240 


Leu Asn Arg Ala Pro Arg Arg Ala Thr Pro Pro Ala His Pro Pro Pro 
                245                 250                 255     


Arg Ser Ser Ser Leu Gly Asn Ser Pro Glu Arg Gly Pro Leu Arg Pro 
            260                 265                 270         


Phe Val Pro Glu Gln Glu Leu Leu Arg Ser Leu Arg Leu Cys Pro Pro 
        275                 280                 285             


His Pro Thr Ala Arg Leu Leu Leu Ala Ala Asp Pro Gly Gly Ser Pro 
    290                 295                 300                 


Ala Gln Arg Arg Arg Thr Arg Gly Thr Pro Pro Gly Leu Val Ala Gln 
305                 310                 315                 320 


Ser Cys Cys Tyr Ser Arg His Gly Gly Val Asn Ser Ser Ser Pro Asn 
                325                 330                 335     


Thr Gly Asn Gln Asp Ser Lys Gln Gly Glu Gln Glu Thr Lys Asn Arg 
            340                 345                 350         


Ser Ala Ser Glu Glu Gln Ala Leu Ser Gln Asp Gly Ser Gly Glu Lys 
        355                 360                 365             


Pro Met His Thr Ala Pro Pro Gln Ala Pro Ala Pro Pro Ala Gln Ser 
    370                 375                 380                 


Trp Thr Val Gly Gly Asp Ile Leu Asn Ala Arg Phe Ile Arg Asn Leu 
385                 390                 395                 400 


Gln Glu Arg Arg Ser Thr Arg Pro Trp 
                405                 


<210>  1216
<211>  331
<212>  PRT
<213>  Homo Sapiens

<400>  1216

Met Ala Val Ala Met Val Lys Leu Cys Glu Arg Ala Gly Leu Pro Leu 
1               5                   10                  15      


Leu Ala Ala Pro Leu Leu Arg Ser Leu Leu Pro Arg Ala Pro Gln Pro 
            20                  25                  30          


Gly Pro Ala Gln Pro Arg Ser Val Gln Gly Gln Arg Cys Pro Ala Arg 
        35                  40                  45              


His Pro Pro Gly Asn Leu Val Cys Glu Arg Gly Ala Gly Val Asn Gly 
    50                  55                  60                  


Val Thr Ala Gly Ala Gly Gly Arg Leu Arg Gly Leu His Arg Gly Gly 
65                  70                  75                  80  


Arg Ala Leu Gly Cys Ser Ala His Arg Pro Leu His Ser Ala Arg Val 
                85                  90                  95      


Arg Pro Pro Ala His Leu Ala Ala Pro Pro Gly Ser Ser Ala Arg Gly 
            100                 105                 110         


Cys Arg Leu Thr Glu Leu Gly Tyr Ala Leu Asn Glu Trp Leu Gln Asp 
        115                 120                 125             


Ile Arg Lys Asn Gln Leu Pro Gly Leu Leu Gly Gly Val Gly Pro Met 
    130                 135                 140                 


His Ser Val Val Gln Leu Phe Gln Gly Phe Arg Asp Leu Leu Trp Leu 
145                 150                 155                 160 


Pro Ile Glu Gln Tyr Arg Lys Asp Gly Arg Leu Met Arg Gly Leu Gln 
                165                 170                 175     


Arg Gly Ala Ala Ser Phe Gly Ser Ser Thr Ala Ser Ala Ala Leu Glu 
            180                 185                 190         


Leu Ser Asn Arg Leu Val Gln Ala Ile Gln Ala Thr Ala Glu Thr Val 
        195                 200                 205             


Tyr Asp Ile Leu Ser Pro Ala Ala Pro Val Ser Arg Ser Leu Gln Asp 
    210                 215                 220                 


Lys Arg Ser Ala Arg Arg Leu Arg Arg Gly Gln Gln Pro Ala Asp Leu 
225                 230                 235                 240 


Arg Glu Gly Val Ala Lys Ala Tyr Asp Thr Val Arg Glu Gly Ile Leu 
                245                 250                 255     


Asp Thr Ala Gln Thr Ile Cys Asp Val Ala Ser Arg Gly His Glu Gln 
            260                 265                 270         


Lys Gly Leu Thr Gly Ala Val Gly Gly Val Ile Arg Gln Leu Pro Pro 
        275                 280                 285             


Thr Val Val Lys Pro Leu Ile Leu Ala Thr Glu Ala Thr Ser Ser Leu 
    290                 295                 300                 


Leu Gly Gly Met Arg Asn Gln Ile Val Pro Asp Ala His Lys Asp His 
305                 310                 315                 320 


Ala Leu Lys Trp Arg Ser Asp Ser Ala Gln Asp 
                325                 330     


<210>  1217
<211>  1938
<212>  PRT
<213>  Homo Sapiens

<400>  1217

Met Ser Arg Trp Leu Trp Pro Trp Ser Asn Cys Val Lys Glu Arg Val 
1               5                   10                  15      


Cys Arg Tyr Leu Leu His His Tyr Leu Gly His Phe Phe Gln Glu His 
            20                  25                  30          


Leu Ser Leu Asp Gln Leu Ser Leu Asp Leu Tyr Lys Gly Ser Val Ala 
        35                  40                  45              


Leu Arg Asp Ile His Leu Glu Ile Trp Ser Val Asn Glu Val Leu Glu 
    50                  55                  60                  


Ser Met Glu Ser Pro Leu Glu Leu Val Glu Gly Phe Val Gly Ser Ile 
65                  70                  75                  80  


Glu Val Ala Val Pro Trp Ala Ala Leu Leu Thr Asp His Cys Thr Val 
                85                  90                  95      


Arg Val Ser Gly Leu Gln Leu Thr Leu Gln Pro Arg Arg Gly Pro Ala 
            100                 105                 110         


Pro Gly Ala Ala Asp Ser Gln Ser Trp Ala Ser Cys Met Thr Thr Ser 
        115                 120                 125             


Leu Gln Leu Ala Gln Glu Cys Leu Arg Asp Gly Leu Pro Glu Pro Ser 
    130                 135                 140                 


Glu Pro Pro Gln Pro Leu Glu Gly Leu Glu Met Phe Ala Gln Thr Ile 
145                 150                 155                 160 


Glu Thr Val Leu Arg Arg Ile Lys Val Thr Phe Leu Asp Thr Val Val 
                165                 170                 175     


Arg Val Glu His Ser Pro Gly Asp Gly Glu Arg Gly Val Ala Val Glu 
            180                 185                 190         


Val Arg Val Gln Arg Leu Glu Tyr Cys Asp Glu Ala Val Arg Asp Pro 
        195                 200                 205             


Ser Gln Ala Pro Pro Val Asp Val His Gln Pro Pro Ala Phe Leu His 
    210                 215                 220                 


Lys Leu Leu Gln Leu Ala Gly Val Arg Leu His Tyr Glu Glu Leu Pro 
225                 230                 235                 240 


Ala Gln Glu Glu Pro Pro Glu Pro Pro Leu Gln Ile Gly Ser Cys Ser 
                245                 250                 255     


Gly Tyr Met Glu Leu Met Val Lys Leu Lys Gln Asn Glu Ala Phe Pro 
            260                 265                 270         


Gly Pro Lys Leu Glu Val Ala Gly Gln Leu Gly Ser Leu His Leu Leu 
        275                 280                 285             


Leu Thr Pro Arg Gln Leu Gln Gln Leu Gln Glu Leu Leu Ser Ala Val 
    290                 295                 300                 


Ser Leu Thr Asp His Glu Gly Leu Ala Asp Lys Leu Asn Lys Ser Arg 
305                 310                 315                 320 


Pro Leu Gly Ala Glu Asp Leu Trp Leu Ile Glu Gln Asp Leu Asn Gln 
                325                 330                 335     


Gln Leu Gln Ala Gly Ala Val Ala Glu Pro Leu Ser Pro Asp Pro Leu 
            340                 345                 350         


Thr Asn Pro Leu Leu Asn Leu Asp Asn Thr Asp Leu Phe Phe Ser Met 
        355                 360                 365             


Ala Gly Leu Thr Ser Ser Val Ala Ser Ala Leu Ser Glu Leu Ser Leu 
    370                 375                 380                 


Ser Asp Val Asp Leu Ala Ser Ser Val Arg Ser Asp Met Ala Ser Arg 
385                 390                 395                 400 


Arg Leu Ser Ala Gln Ala His Pro Ala Gly Lys Met Ala Pro Asn Pro 
                405                 410                 415     


Leu Leu Asp Thr Met Arg Pro Asp Ser Leu Leu Lys Met Thr Leu Gly 
            420                 425                 430         


Gly Val Thr Leu Thr Leu Leu Gln Thr Ser Ala Pro Ser Ser Gly Pro 
        435                 440                 445             


Pro Asp Leu Ala Thr His Phe Phe Thr Glu Phe Asp Ala Thr Lys Asp 
    450                 455                 460                 


Gly Pro Phe Gly Ser Arg Asp Phe His His Leu Arg Pro Arg Phe Gln 
465                 470                 475                 480 


Arg Ala Cys Pro Cys Ser His Val Arg Leu Thr Gly Thr Ala Val Gln 
                485                 490                 495     


Leu Ser Trp Glu Leu Arg Thr Gly Ser Arg Gly Arg Arg Thr Thr Ser 
            500                 505                 510         


Met Glu Val His Phe Gly Gln Leu Glu Val Leu Glu Cys Leu Trp Pro 
        515                 520                 525             


Arg Gly Thr Ser Glu Pro Glu Tyr Thr Glu Ile Leu Thr Phe Pro Gly 
    530                 535                 540                 


Thr Leu Gly Ser Gln Ala Ser Ala Arg Pro Cys Ala His Leu Arg His 
545                 550                 555                 560 


Thr Gln Ile Leu Arg Arg Val Pro Lys Ser Arg Pro Arg Arg Ser Val 
                565                 570                 575     


Ala Cys His Cys His Ser Glu Leu Ala Leu Asp Leu Ala Asn Phe Gln 
            580                 585                 590         


Ala Asp Val Glu Leu Gly Ala Leu Asp Arg Leu Ala Ala Leu Leu Arg 
        595                 600                 605             


Leu Ala Thr Val Pro Ala Glu Pro Pro Ala Gly Leu Leu Thr Glu Pro 
    610                 615                 620                 


Leu Pro Ala Met Glu Gln Gln Thr Val Phe Arg Leu Ser Ala Pro Arg 
625                 630                 635                 640 


Ala Thr Leu Arg Leu Arg Phe Pro Ile Ala Asp Leu Arg Pro Glu Pro 
                645                 650                 655     


Asp Pro Trp Ala Gly Gln Ala Val Arg Ala Glu Gln Leu Arg Leu Glu 
            660                 665                 670         


Leu Ser Glu Pro Gln Phe Arg Ser Glu Leu Ser Ser Gly Pro Gly Pro 
        675                 680                 685             


Pro Val Pro Thr His Leu Glu Leu Thr Cys Ser Asp Leu His Gly Ile 
    690                 695                 700                 


Tyr Glu Asp Gly Gly Lys Pro Pro Val Pro Cys Leu Arg Val Ser Lys 
705                 710                 715                 720 


Ala Leu Asp Pro Lys Ser Thr Gly Arg Lys Tyr Phe Leu Pro Gln Val 
                725                 730                 735     


Val Val Thr Val Asn Pro Gln Ser Ser Ser Thr Gln Trp Glu Val Ala 
            740                 745                 750         


Pro Glu Lys Gly Glu Glu Leu Glu Leu Ser Val Glu Ser Pro Cys Glu 
        755                 760                 765             


Leu Arg Glu Pro Glu Pro Ser Pro Phe Ser Ser Lys Arg Thr Met Tyr 
    770                 775                 780                 


Glu Thr Glu Glu Met Val Ile Pro Gly Asp Pro Glu Glu Met Arg Thr 
785                 790                 795                 800 


Phe Gln Ser Arg Thr Leu Ala Leu Ser Arg Cys Ser Leu Glu Val Ile 
                805                 810                 815     


Leu Pro Ser Val His Ile Phe Leu Pro Ser Lys Glu Val Tyr Glu Ser 
            820                 825                 830         


Ile Tyr Asn Arg Ile Asn Asn Asp Leu Leu Met Trp Glu Pro Ala Asp 
        835                 840                 845             


Leu Leu Pro Thr Pro Asp Pro Ala Ala Gln Pro Ser Gly Phe Pro Gly 
    850                 855                 860                 


Pro Ser Gly Phe Trp His Asp Ser Phe Lys Met Cys Lys Ser Ala Phe 
865                 870                 875                 880 


Lys Leu Ala Asn Cys Phe Asp Leu Thr Pro Asp Ser Asp Ser Asp Asp 
                885                 890                 895     


Glu Asp Ala His Phe Phe Ser Val Gly Ala Ser Gly Gly Pro Gln Ala 
            900                 905                 910         


Ala Ala Pro Glu Ala Pro Ser Leu His Leu Gln Ser Thr Phe Ser Thr 
        915                 920                 925             


Leu Val Thr Val Leu Lys Gly Arg Ile Thr Ala Leu Cys Glu Thr Lys 
    930                 935                 940                 


Asp Glu Gly Gly Lys Arg Leu Glu Ala Val His Gly Glu Leu Val Leu 
945                 950                 955                 960 


Asp Met Glu His Gly Thr Leu Phe Ser Val Ser Gln Tyr Cys Gly Gln 
                965                 970                 975     


Pro Gly Leu Gly Tyr Phe Cys Leu Glu Ala Glu Lys Ala Thr Leu Tyr 
            980                 985                 990         


His Arg Ala Ala Val Asp Asp Tyr  Pro Leu Pro Ser His  Leu Asp Leu 
        995                 1000                 1005             


Pro Ser  Phe Ala Pro Pro Ala  Gln Leu Ala Pro Thr  Ile Tyr Pro 
    1010                 1015                 1020             


Ser Glu  Glu Gly Val Thr Glu  Arg Gly Ala Ser Gly  Arg Lys Gly 
    1025                 1030                 1035             


Gln Gly  Arg Gly Pro His Met  Leu Ser Thr Ala Val  Arg Ile His 
    1040                 1045                 1050             


Leu Asp  Pro His Lys Asn Val  Lys Glu Phe Leu Val  Thr Leu Arg 
    1055                 1060                 1065             


Leu His  Lys Ala Thr Leu Arg  His Tyr Met Ala Leu  Pro Glu Gln 
    1070                 1075                 1080             


Ser Trp  His Ser Gln Leu Leu  Glu Phe Leu Asp Val  Leu Asp Asp 
    1085                 1090                 1095             


Pro Val  Leu Gly Tyr Leu Pro  Pro Thr Val Ile Thr  Ile Leu His 
    1100                 1105                 1110             


Thr His  Leu Phe Ser Cys Ser  Val Asp Tyr Arg Pro  Leu Tyr Leu 
    1115                 1120                 1125             


Pro Val  Arg Val Leu Ile Thr  Ala Glu Thr Phe Thr  Leu Ser Ser 
    1130                 1135                 1140             


Asn Ile  Ile Met Asp Thr Ser  Thr Phe Leu Leu Arg  Phe Ile Leu 
    1145                 1150                 1155             


Asp Asp  Ser Ala Leu Tyr Leu  Ser Asp Lys Cys Glu  Val Glu Thr 
    1160                 1165                 1170             


Leu Asp  Leu Arg Arg Asp Tyr  Val Cys Val Leu Asp  Val Asp Leu 
    1175                 1180                 1185             


Leu Glu  Leu Val Ile Lys Thr  Trp Lys Gly Ser Thr  Glu Gly Lys 
    1190                 1195                 1200             


Leu Ser  Gln Pro Leu Phe Glu  Leu Arg Cys Ser Asn  Asn Val Val 
    1205                 1210                 1215             


His Val  His Ser Cys Ala Asp  Ser Cys Ala Leu Leu  Val Asn Leu 
    1220                 1225                 1230             


Leu Gln  Tyr Val Met Ser Thr  Gly Asp Leu His Pro  Pro Pro Arg 
    1235                 1240                 1245             


Pro Pro  Ser Pro Thr Glu Ile  Ala Gly Gln Lys Leu  Ser Glu Ser 
    1250                 1255                 1260             


Pro Ala  Ser Leu Pro Ser Cys  Pro Pro Val Glu Thr  Ala Leu Ile 
    1265                 1270                 1275             


Asn Gln  Arg Asp Leu Ala Asp  Ala Leu Leu Asp Thr  Glu Arg Ser 
    1280                 1285                 1290             


Leu Arg  Glu Leu Ala Gln Pro  Ser Gly Gly His Leu  Pro Gln Ala 
    1295                 1300                 1305             


Ser Pro  Ile Ser Val Tyr Leu  Phe Pro Gly Glu Arg  Ser Gly Ala 
    1310                 1315                 1320             


Pro Pro  Pro Ser Pro Pro Val  Gly Gly Pro Ala Gly  Ser Leu Gly 
    1325                 1330                 1335             


Ser Cys  Ser Glu Glu Lys Glu  Asp Glu Arg Glu Glu  Glu Gly Asp 
    1340                 1345                 1350             


Gly Asp  Thr Leu Asp Ser Asp  Glu Phe Cys Ile Leu  Asp Ala Pro 
    1355                 1360                 1365             


Gly Leu  Gly Ile Pro Pro Arg  Asp Gly Glu Pro Val  Val Thr Gln 
    1370                 1375                 1380             


Leu His  Pro Gly Pro Ile Val  Val Arg Asp Gly Tyr  Phe Ser Arg 
    1385                 1390                 1395             


Pro Ile  Gly Ser Thr Asp Leu  Leu Arg Ala Pro Ala  His Phe Pro 
    1400                 1405                 1410             


Val Pro  Ser Thr Arg Val Val  Leu Arg Glu Val Ser  Leu Val Trp 
    1415                 1420                 1425             


His Leu  Tyr Gly Gly Arg Asp  Phe Gly Pro His Pro  Gly His Arg 
    1430                 1435                 1440             


Ala Arg  Thr Gly Leu Ser Gly  Pro Arg Ser Ser Pro  Ser Arg Cys 
    1445                 1450                 1455             


Ser Gly  Pro Asn Arg Pro Gln  Asn Ser Trp Arg Thr  Gln Gly Gly 
    1460                 1465                 1470             


Ser Gly  Arg Gln His His Val  Leu Met Glu Ile Gln  Leu Ser Lys 
    1475                 1480                 1485             


Val Ser  Phe Gln His Glu Val  Tyr Pro Ala Glu Pro  Ala Thr Gly 
    1490                 1495                 1500             


Pro Ala  Ala Pro Ser Gln Glu  Leu Glu Glu Arg Pro  Leu Ser Arg 
    1505                 1510                 1515             


Gln Val  Phe Ile Val Gln Glu  Leu Glu Val Arg Asp  Arg Leu Ala 
    1520                 1525                 1530             


Ser Ser  Gln Ile Asn Lys Phe  Leu Tyr Leu His Thr  Ser Glu Arg 
    1535                 1540                 1545             


Met Pro  Arg Arg Ala His Ser  Asn Met Leu Thr Ile  Lys Ala Leu 
    1550                 1555                 1560             


His Val  Ala Pro Thr Thr Asn  Leu Gly Gly Pro Glu  Cys Cys Leu 
    1565                 1570                 1575             


Arg Val  Ser Leu Met Pro Leu  Arg Leu Asn Val Asp  Gln Asp Ala 
    1580                 1585                 1590             


Leu Phe  Phe Leu Lys Asp Phe  Phe Thr Ser Leu Val  Ala Gly Ile 
    1595                 1600                 1605             


Asn Pro  Val Val Pro Gly Glu  Thr Ser Ala Glu Ala  Arg Pro Glu 
    1610                 1615                 1620             


Thr Arg  Ala Gln Pro Ser Ser  Pro Leu Glu Gly Gln  Ala Glu Gly 
    1625                 1630                 1635             


Val Glu  Thr Thr Gly Ser Gln  Glu Ala Pro Gly Gly  Gly His Ser 
    1640                 1645                 1650             


Pro Ser  Pro Pro Asp Gln Gln  Pro Ile Tyr Phe Arg  Glu Phe Arg 
    1655                 1660                 1665             


Phe Thr  Ser Glu Val Pro Ile  Trp Leu Asp Tyr His  Gly Lys His 
    1670                 1675                 1680             


Val Thr  Met Asp Gln Val Gly  Thr Phe Ala Gly Leu  Leu Ile Gly 
    1685                 1690                 1695             


Leu Ala  Gln Leu Asn Cys Ser  Glu Leu Lys Leu Lys  Arg Leu Cys 
    1700                 1705                 1710             


Cys Arg  His Gly Leu Leu Gly  Val Asp Lys Val Leu  Gly Tyr Ala 
    1715                 1720                 1725             


Leu Asn  Glu Trp Leu Gln Asp  Ile Arg Lys Asn Gln  Leu Pro Gly 
    1730                 1735                 1740             


Leu Leu  Gly Gly Val Gly Pro  Met His Ser Val Val  Gln Leu Phe 
    1745                 1750                 1755             


Gln Gly  Phe Arg Asp Leu Leu  Trp Leu Pro Ile Glu  Gln Tyr Arg 
    1760                 1765                 1770             


Lys Asp  Gly Arg Leu Met Arg  Gly Leu Gln Arg Gly  Ala Ala Ser 
    1775                 1780                 1785             


Phe Gly  Ser Ser Thr Ala Ser  Ala Ala Leu Glu Leu  Ser Asn Arg 
    1790                 1795                 1800             


Leu Val  Gln Ala Ile Gln Ala  Thr Ala Glu Thr Val  Tyr Asp Ile 
    1805                 1810                 1815             


Leu Ser  Pro Ala Ala Pro Val  Ser Arg Ser Leu Gln  Asp Lys Arg 
    1820                 1825                 1830             


Ser Ala  Arg Arg Leu Arg Arg  Gly Gln Gln Pro Ala  Asp Leu Arg 
    1835                 1840                 1845             


Glu Gly  Val Ala Lys Ala Tyr  Asp Thr Val Arg Glu  Gly Ile Leu 
    1850                 1855                 1860             


Asp Thr  Ala Gln Thr Ile Cys  Asp Val Ala Ser Arg  Gly His Glu 
    1865                 1870                 1875             


Gln Lys  Gly Leu Thr Gly Ala  Val Gly Gly Val Ile  Arg Gln Leu 
    1880                 1885                 1890             


Pro Pro  Thr Val Val Lys Pro  Leu Ile Leu Ala Thr  Glu Ala Thr 
    1895                 1900                 1905             


Ser Ser  Leu Leu Gly Gly Met  Arg Asn Gln Ile Val  Pro Asp Ala 
    1910                 1915                 1920             


His Lys  Asp His Ala Leu Lys  Trp Arg Ser Asp Ser  Ala Gln Asp 
    1925                 1930                 1935             


<210>  1218
<211>  1742
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1218

Xaa Tyr Cys Asp Glu Ala Val Arg Asp Pro Ser Gln Ala Pro Pro Val 
1               5                   10                  15      


Asp Val His Gln Pro Pro Ala Phe Leu His Lys Leu Leu Gln Leu Ala 
            20                  25                  30          


Gly Val Arg Leu His Tyr Glu Glu Leu Pro Ala Gln Glu Glu Pro Pro 
        35                  40                  45              


Glu Pro Pro Leu Gln Ile Gly Ser Cys Ser Gly Tyr Met Glu Leu Met 
    50                  55                  60                  


Val Lys Leu Lys Gln Asn Glu Ala Phe Pro Gly Pro Lys Leu Glu Val 
65                  70                  75                  80  


Ala Gly Gln Leu Gly Ser Leu His Leu Leu Leu Thr Pro Arg Gln Leu 
                85                  90                  95      


Gln Gln Leu Gln Glu Leu Leu Ser Ala Val Ser Leu Thr Asp His Glu 
            100                 105                 110         


Gly Leu Ala Asp Lys Leu Asn Lys Ser Arg Pro Leu Gly Ala Glu Asp 
        115                 120                 125             


Leu Trp Leu Ile Glu Gln Asp Leu Asn Gln Gln Leu Gln Ala Gly Ala 
    130                 135                 140                 


Val Ala Glu Pro Leu Ser Pro Asp Pro Leu Thr Asn Pro Leu Leu Asn 
145                 150                 155                 160 


Leu Asp Asn Thr Asp Leu Phe Phe Ser Met Ala Gly Leu Thr Ser Ser 
                165                 170                 175     


Val Ala Ser Ala Leu Ser Glu Leu Ser Leu Ser Asp Val Asp Leu Ala 
            180                 185                 190         


Ser Ser Val Arg Ser Asp Met Ala Ser Arg Arg Leu Ser Ala Gln Ala 
        195                 200                 205             


His Pro Ala Gly Lys Met Ala Pro Asn Pro Leu Leu Asp Thr Met Arg 
    210                 215                 220                 


Pro Asp Ser Leu Leu Lys Met Thr Leu Gly Gly Val Thr Leu Thr Leu 
225                 230                 235                 240 


Leu Gln Thr Ser Ala Pro Ser Ser Gly Pro Pro Asp Leu Ala Thr His 
                245                 250                 255     


Phe Phe Thr Glu Phe Asp Ala Thr Lys Asp Gly Pro Phe Gly Ser Arg 
            260                 265                 270         


Asp Phe His His Leu Arg Pro Arg Phe Gln Arg Ala Cys Pro Cys Ser 
        275                 280                 285             


His Val Arg Leu Thr Gly Thr Ala Val Gln Leu Ser Trp Glu Leu Arg 
    290                 295                 300                 


Thr Gly Ser Arg Gly Arg Arg Thr Thr Ser Met Glu Val His Phe Gly 
305                 310                 315                 320 


Gln Leu Glu Val Leu Glu Cys Leu Trp Pro Arg Gly Thr Ser Glu Pro 
                325                 330                 335     


Glu Tyr Thr Glu Ile Leu Thr Phe Pro Gly Thr Leu Gly Ser Gln Ala 
            340                 345                 350         


Ser Ala Arg Pro Cys Ala His Leu Arg His Thr Gln Ile Leu Arg Arg 
        355                 360                 365             


Val Pro Lys Ser Arg Pro Arg Arg Ser Val Ala Cys His Cys His Ser 
    370                 375                 380                 


Glu Leu Ala Leu Asp Leu Ala Asn Phe Gln Ala Asp Val Glu Leu Gly 
385                 390                 395                 400 


Ala Leu Asp Arg Leu Ala Ala Leu Leu Arg Leu Ala Thr Val Pro Ala 
                405                 410                 415     


Glu Pro Pro Ala Gly Leu Leu Thr Glu Pro Leu Pro Ala Met Glu Gln 
            420                 425                 430         


Gln Thr Val Phe Arg Leu Ser Ala Pro Arg Ala Thr Leu Arg Leu Arg 
        435                 440                 445             


Phe Pro Ile Ala Asp Leu Arg Pro Glu Pro Asp Pro Trp Ala Gly Gln 
    450                 455                 460                 


Ala Val Arg Ala Glu Gln Leu Arg Leu Glu Leu Ser Glu Pro Gln Phe 
465                 470                 475                 480 


Arg Ser Glu Leu Ser Ser Gly Pro Gly Pro Pro Val Pro Thr His Leu 
                485                 490                 495     


Glu Leu Thr Cys Ser Asp Leu His Gly Ile Tyr Glu Asp Gly Gly Lys 
            500                 505                 510         


Pro Pro Val Pro Cys Leu Arg Val Ser Lys Ala Leu Asp Pro Lys Ser 
        515                 520                 525             


Thr Gly Arg Lys Tyr Phe Leu Pro Gln Val Val Val Thr Val Asn Pro 
    530                 535                 540                 


Gln Ser Ser Ser Thr Gln Trp Glu Val Ala Pro Glu Lys Gly Glu Glu 
545                 550                 555                 560 


Leu Glu Leu Ser Val Glu Ser Pro Cys Glu Leu Arg Glu Pro Glu Pro 
                565                 570                 575     


Ser Pro Phe Ser Ser Lys Arg Thr Met Tyr Glu Thr Glu Glu Met Val 
            580                 585                 590         


Ile Pro Gly Asp Pro Glu Glu Met Arg Thr Phe Gln Ser Arg Thr Leu 
        595                 600                 605             


Ala Leu Ser Arg Cys Ser Leu Glu Val Ile Leu Pro Ser Val His Ile 
    610                 615                 620                 


Phe Leu Pro Ser Lys Glu Val Tyr Glu Ser Ile Tyr Asn Arg Ile Asn 
625                 630                 635                 640 


Asn Asp Leu Leu Met Trp Glu Pro Ala Asp Leu Leu Pro Thr Pro Asp 
                645                 650                 655     


Pro Ala Ala Gln Pro Ser Gly Phe Pro Gly Pro Ser Gly Phe Trp His 
            660                 665                 670         


Asp Ser Phe Lys Met Cys Lys Ser Ala Phe Lys Leu Ala Asn Cys Phe 
        675                 680                 685             


Asp Leu Thr Pro Asp Ser Asp Ser Asp Asp Glu Asp Ala His Phe Phe 
    690                 695                 700                 


Ser Val Gly Ala Ser Gly Gly Pro Gln Ala Ala Ala Pro Glu Ala Pro 
705                 710                 715                 720 


Ser Leu His Leu Gln Ser Thr Phe Ser Thr Leu Val Thr Val Leu Lys 
                725                 730                 735     


Gly Arg Ile Thr Ala Leu Cys Glu Thr Lys Asp Glu Gly Gly Lys Arg 
            740                 745                 750         


Leu Glu Ala Val His Gly Glu Leu Val Leu Asp Met Glu His Gly Thr 
        755                 760                 765             


Leu Phe Ser Val Ser Gln Tyr Cys Gly Gln Pro Gly Leu Gly Tyr Phe 
    770                 775                 780                 


Cys Leu Glu Ala Glu Lys Ala Thr Leu Tyr His Arg Ala Ala Val Asp 
785                 790                 795                 800 


Asp Tyr Pro Leu Pro Ser His Leu Asp Leu Pro Ser Phe Ala Pro Pro 
                805                 810                 815     


Ala Gln Leu Ala Pro Thr Ile Tyr Pro Ser Glu Glu Gly Val Thr Glu 
            820                 825                 830         


Arg Gly Ala Ser Gly Arg Lys Gly Gln Gly Arg Gly Pro His Met Leu 
        835                 840                 845             


Ser Thr Ala Val Arg Ile His Leu Asp Pro His Lys Asn Val Lys Glu 
    850                 855                 860                 


Phe Leu Val Thr Leu Arg Leu His Lys Ala Thr Leu Arg His Tyr Met 
865                 870                 875                 880 


Ala Leu Pro Glu Gln Ser Trp His Ser Gln Leu Leu Glu Phe Leu Asp 
                885                 890                 895     


Val Leu Asp Asp Pro Val Leu Gly Tyr Leu Pro Pro Thr Val Ile Thr 
            900                 905                 910         


Ile Leu His Thr His Leu Phe Ser Cys Ser Val Asp Tyr Arg Pro Leu 
        915                 920                 925             


Tyr Leu Pro Val Arg Val Leu Ile Thr Ala Glu Thr Phe Thr Leu Ser 
    930                 935                 940                 


Ser Asn Ile Ile Met Asp Thr Ser Thr Phe Leu Leu Arg Phe Ile Leu 
945                 950                 955                 960 


Asp Asp Ser Ala Leu Tyr Leu Ser Asp Lys Cys Glu Val Glu Thr Leu 
                965                 970                 975     


Asp Leu Arg Arg Asp Tyr Val Cys Val Leu Asp Val Asp Leu Leu Glu 
            980                 985                 990         


Leu Val Ile Lys Thr Trp Lys Gly  Ser Thr Glu Gly Lys  Leu Ser Gln 
        995                 1000                 1005             


Pro Leu  Phe Glu Leu Arg Cys  Ser Asn Asn Val Val  His Val His 
    1010                 1015                 1020             


Ser Cys  Ala Asp Ser Cys Ala  Leu Leu Val Asn Leu  Leu Gln Tyr 
    1025                 1030                 1035             


Val Met  Ser Thr Gly Asp Leu  His Pro Pro Pro Arg  Pro Pro Ser 
    1040                 1045                 1050             


Pro Thr  Glu Ile Ala Gly Gln  Lys Val Gln Leu Ser  Glu Ser Pro 
    1055                 1060                 1065             


Ala Ser  Leu Pro Ser Cys Pro  Pro Val Glu Thr Ala  Leu Ile Asn 
    1070                 1075                 1080             


Gln Arg  Asp Leu Ala Asp Ala  Leu Leu Asp Thr Glu  Arg Ser Leu 
    1085                 1090                 1095             


Arg Glu  Leu Ala Gln Pro Ser  Gly Gly His Leu Pro  Gln Ala Ser 
    1100                 1105                 1110             


Pro Ile  Ser Val Tyr Leu Phe  Pro Gly Glu Arg Ser  Gly Ala Pro 
    1115                 1120                 1125             


Pro Pro  Ser Pro Pro Val Gly  Gly Pro Ala Gly Ser  Leu Gly Ser 
    1130                 1135                 1140             


Cys Ser  Glu Glu Lys Glu Asp  Glu Arg Glu Glu Glu  Gly Asp Gly 
    1145                 1150                 1155             


Asp Thr  Leu Asp Ser Asp Glu  Phe Cys Ile Leu Asp  Ala Pro Gly 
    1160                 1165                 1170             


Leu Gly  Ile Pro Pro Arg Asp  Gly Glu Pro Val Val  Thr Gln Leu 
    1175                 1180                 1185             


His Pro  Gly Pro Ile Val Val  Arg Asp Gly Tyr Phe  Ser Arg Pro 
    1190                 1195                 1200             


Ile Gly  Ser Thr Asp Leu Leu  Arg Ala Pro Ala His  Phe Pro Val 
    1205                 1210                 1215             


Pro Ser  Thr Arg Val Val Leu  Arg Glu Val Ser Leu  Val Trp His 
    1220                 1225                 1230             


Leu Tyr  Gly Gly Arg Asp Phe  Gly Pro His Pro Gly  His Arg Ala 
    1235                 1240                 1245             


Arg Thr  Gly Leu Ser Gly Pro  Arg Ser Ser Pro Ser  Arg Cys Ser 
    1250                 1255                 1260             


Gly Pro  Asn Arg Pro Gln Asn  Ser Trp Arg Thr Gln  Gly Gly Ser 
    1265                 1270                 1275             


Gly Arg  Gln His His Val Leu  Met Glu Ile Gln Leu  Ser Lys Val 
    1280                 1285                 1290             


Ser Phe  Gln His Glu Val Tyr  Pro Ala Glu Pro Ala  Thr Gly Pro 
    1295                 1300                 1305             


Ala Ala  Pro Ser Gln Glu Leu  Glu Glu Arg Pro Leu  Ser Arg Gln 
    1310                 1315                 1320             


Val Phe  Ile Val Gln Glu Leu  Glu Val Arg Asp Arg  Leu Ala Ser 
    1325                 1330                 1335             


Ser Gln  Ile Asn Lys Phe Leu  Tyr Leu His Thr Ser  Glu Arg Met 
    1340                 1345                 1350             


Pro Arg  Arg Ala His Ser Asn  Met Leu Thr Ile Lys  Ala Leu His 
    1355                 1360                 1365             


Val Ala  Pro Thr Thr Asn Leu  Gly Gly Pro Glu Cys  Cys Leu Arg 
    1370                 1375                 1380             


Val Ser  Leu Met Pro Leu Arg  Leu Asn Val Asp Gln  Asp Ala Leu 
    1385                 1390                 1395             


Phe Phe  Leu Lys Asp Phe Phe  Thr Ser Leu Val Ala  Gly Ile Asn 
    1400                 1405                 1410             


Pro Val  Val Pro Gly Glu Thr  Ser Ala Glu Ala Arg  Pro Glu Thr 
    1415                 1420                 1425             


Arg Ala  Gln Pro Ser Ser Pro  Leu Glu Gly Gln Ala  Glu Gly Val 
    1430                 1435                 1440             


Glu Thr  Thr Gly Ser Gln Glu  Ala Pro Gly Gly Gly  His Ser Pro 
    1445                 1450                 1455             


Ser Pro  Pro Asp Gln Gln Pro  Ile Tyr Phe Arg Glu  Phe Arg Phe 
    1460                 1465                 1470             


Thr Ser  Glu Val Pro Ile Trp  Leu Asp Tyr His Gly  Lys His Val 
    1475                 1480                 1485             


Thr Met  Asp Gln Val Gly Thr  Phe Ala Gly Leu Leu  Ile Gly Leu 
    1490                 1495                 1500             


Ala Gln  Leu Asn Cys Ser Glu  Leu Lys Leu Lys Arg  Leu Cys Cys 
    1505                 1510                 1515             


Arg His  Gly Leu Leu Gly Val  Asp Lys Val Leu Gly  Tyr Ala Leu 
    1520                 1525                 1530             


Asn Glu  Trp Leu Gln Asp Ile  Arg Lys Asn Gln Leu  Pro Gly Leu 
    1535                 1540                 1545             


Leu Gly  Gly Val Gly Pro Met  His Ser Val Val Gln  Leu Phe Gln 
    1550                 1555                 1560             


Gly Phe  Arg Asp Leu Leu Trp  Leu Pro Ile Glu Gln  Tyr Arg Lys 
    1565                 1570                 1575             


Asp Gly  Arg Leu Met Arg Gly  Leu Gln Arg Gly Ala  Ala Ser Phe 
    1580                 1585                 1590             


Gly Ser  Ser Thr Ala Ser Ala  Ala Leu Glu Leu Ser  Asn Arg Leu 
    1595                 1600                 1605             


Val Gln  Ala Ile Gln Ala Thr  Ala Glu Thr Val Tyr  Asp Ile Leu 
    1610                 1615                 1620             


Ser Pro  Ala Ala Pro Val Ser  Arg Ser Leu Gln Asp  Lys Arg Ser 
    1625                 1630                 1635             


Ala Arg  Arg Leu Arg Arg Gly  Gln Gln Pro Ala Asp  Leu Arg Glu 
    1640                 1645                 1650             


Gly Val  Ala Lys Ala Tyr Asp  Thr Val Arg Glu Gly  Ile Leu Asp 
    1655                 1660                 1665             


Thr Ala  Gln Thr Ile Cys Asp  Val Ala Ser Arg Gly  His Glu Gln 
    1670                 1675                 1680             


Lys Gly  Leu Thr Gly Ala Val  Gly Gly Val Ile Arg  Gln Leu Pro 
    1685                 1690                 1695             


Pro Thr  Val Val Lys Pro Leu  Ile Leu Ala Thr Glu  Ala Thr Ser 
    1700                 1705                 1710             


Ser Leu  Leu Gly Gly Met Arg  Asn Gln Ile Val Pro  Asp Ala His 
    1715                 1720                 1725             


Lys Asp  His Ala Leu Lys Trp  Arg Ser Asp Ser Ala  Gln Asp 
    1730                 1735                 1740         


<210>  1219
<211>  153
<212>  PRT
<213>  Homo Sapiens

<400>  1219

Met His Tyr Pro Ile Gly Leu Leu Phe Asp Leu Leu Ala Ser Ser Ser 
1               5                   10                  15      


Ala Leu Pro Trp Asn Ile Thr Val His Phe Lys Ser Phe Pro Glu Lys 
            20                  25                  30          


Asp Leu Leu His Cys Pro Ser Lys Asp Ala Ile Glu Ala His Phe Met 
        35                  40                  45              


Ser Cys Met Lys Glu Ala Asp Ala Leu Lys His Lys Ser Gln Val Ile 
    50                  55                  60                  


Asn Glu Met Gln Lys Lys Asp His Lys Gln Leu Trp Met Gly Leu Gln 
65                  70                  75                  80  


Asn Asp Arg Phe Asp Gln Phe Trp Ala Ile Asn Arg Lys Leu Met Glu 
                85                  90                  95      


Tyr Pro Ala Glu Glu Asn Gly Phe Arg Tyr Ile Pro Phe Arg Ile Tyr 
            100                 105                 110         


Gln Thr Thr Thr Glu Arg Pro Phe Ile Gln Lys Leu Phe Arg Pro Val 
        115                 120                 125             


Ala Ala Asp Gly Gln Leu His Thr Leu Gly Asp Leu Leu Lys Glu Val 
    130                 135                 140                 


Cys Pro Ser Ala Ile Asp Pro Glu Asp 
145                 150             


<210>  1220
<211>  197
<212>  PRT
<213>  Homo Sapiens

<400>  1220

Met His Tyr Pro Ile Gly Leu Leu Phe Asp Leu Leu Ala Ser Ser Ser 
1               5                   10                  15      


Ala Leu Pro Trp Asn Ile Thr Val His Phe Lys Ser Phe Pro Glu Lys 
            20                  25                  30          


Asp Leu Leu His Cys Pro Ser Lys Asp Ala Ile Glu Ala His Phe Met 
        35                  40                  45              


Ser Cys Met Lys Glu Ala Asp Ala Leu Lys His Lys Ser Gln Val Ile 
    50                  55                  60                  


Asn Glu Met Gln Lys Lys Asp His Lys Gln Leu Trp Met Gly Leu Gln 
65                  70                  75                  80  


Asn Asp Arg Phe Asp Gln Phe Trp Ala Ile Asn Arg Lys Leu Met Glu 
                85                  90                  95      


Tyr Pro Ala Glu Glu Asn Gly Phe Arg Tyr Ile Pro Phe Arg Ile Tyr 
            100                 105                 110         


Gln Thr Thr Thr Glu Arg Pro Phe Ile Gln Lys Leu Phe Arg Pro Val 
        115                 120                 125             


Ala Ala Asp Gly Gln Leu His Thr Leu Gly Asp Leu Leu Lys Glu Val 
    130                 135                 140                 


Cys Pro Ser Ala Ile Asp Pro Glu Asp Gly Glu Lys Lys Asn Gln Val 
145                 150                 155                 160 


Met Ile His Gly Ile Glu Pro Met Leu Glu Thr Pro Leu Gln Trp Leu 
                165                 170                 175     


Ser Glu His Leu Ser Tyr Pro Asp Asn Phe Leu His Ile Ser Ile Ile 
            180                 185                 190         


Pro Gln Pro Thr Asp 
        195         


<210>  1221
<211>  159
<212>  PRT
<213>  Homo Sapiens

<400>  1221

Met His Tyr Pro Ile Gly Leu Leu Phe Asp Leu Leu Ala Ser Ser Ser 
1               5                   10                  15      


Ala Leu Pro Trp Asn Ile Thr Val His Phe Lys Ser Phe Pro Glu Lys 
            20                  25                  30          


Asp Leu Leu His Cys Pro Ser Lys Asp Ala Ile Glu Ala His Phe Met 
        35                  40                  45              


Ser Cys Met Lys Glu Ala Asp Ala Leu Lys His Lys Ser Gln Val Ile 
    50                  55                  60                  


Asn Glu Met Gln Lys Lys Asp His Lys Gln Leu Trp Met Gly Leu Gln 
65                  70                  75                  80  


Asn Asp Arg Phe Asp Gln Phe Trp Ala Ile Asn Arg Lys Leu Met Glu 
                85                  90                  95      


Tyr Pro Ala Glu Glu Asn Gly Phe Arg Tyr Ile Pro Phe Arg Ile Tyr 
            100                 105                 110         


Gln Thr Thr Thr Glu Arg Pro Phe Ile Gln Lys Leu Phe Arg Pro Val 
        115                 120                 125             


Ala Ala Asp Gly Gln Leu His Thr Leu Gly Asp Leu Leu Lys Glu Val 
    130                 135                 140                 


Cys Pro Ser Ala Ile Asp Pro Glu Glu Ile Pro Pro Gly Glu Asp 
145                 150                 155                 


<210>  1222
<211>  44
<212>  PRT
<213>  Homo Sapiens

<400>  1222

Met Thr Asp Asp Lys Asp Val Leu Arg Asp Val Trp Phe Gly Arg Ile 
1               5                   10                  15      


Pro Thr Cys Phe Thr Leu Tyr Gln Asp Glu Ile Thr Glu Arg Glu Ala 
            20                  25                  30          


Glu Pro Tyr Tyr Ala Leu Ser Asn Trp Phe Ala Ile 
        35                  40                  


<210>  1223
<211>  162
<212>  PRT
<213>  Homo Sapiens

<400>  1223

Met Thr Asp Asp Lys Asp Val Leu Arg Asp Val Trp Phe Gly Arg Ile 
1               5                   10                  15      


Pro Thr Cys Phe Thr Leu Tyr Gln Asp Glu Ile Thr Glu Arg Glu Ala 
            20                  25                  30          


Glu Pro Tyr Tyr Leu Leu Leu Pro Arg Val Ser Tyr Leu Thr Leu Val 
        35                  40                  45              


Thr Asp Lys Val Lys Lys His Phe Gln Lys Val Met Arg Gln Glu Asp 
    50                  55                  60                  


Ile Ser Glu Ile Trp Phe Glu Tyr Glu Gly Thr Pro Leu Lys Trp His 
65                  70                  75                  80  


Tyr Pro Ile Gly Leu Leu Phe Asp Leu Leu Ala Ser Ser Ser Ala Leu 
                85                  90                  95      


Pro Trp Asn Ile Thr Val His Phe Lys Ser Phe Pro Glu Lys Asp Leu 
            100                 105                 110         


Leu His Cys Pro Ser Lys Asp Ala Ile Glu Ala His Phe Met Ser Cys 
        115                 120                 125             


Met Lys Glu Ala Asp Ala Leu Lys His Lys Ser Gln Val Ile Asn Glu 
    130                 135                 140                 


Met Gln Lys Lys Asp His Lys Gln Leu Trp Met Gly Leu Gln Asn Asp 
145                 150                 155                 160 


Asn Asp 
        


<210>  1224
<211>  275
<212>  PRT
<213>  Homo Sapiens

<400>  1224

Met Thr Asp Asp Lys Asp Val Leu Arg Asp Val Trp Phe Gly Arg Ile 
1               5                   10                  15      


Pro Thr Cys Phe Thr Leu Tyr Gln Asp Glu Ile Thr Glu Arg Glu Ala 
            20                  25                  30          


Glu Pro Tyr Tyr Leu Leu Leu Pro Arg Val Ser Tyr Leu Thr Leu Val 
        35                  40                  45              


Thr Asp Lys Val Lys Lys His Phe Gln Lys Val Met Arg Gln Glu Asp 
    50                  55                  60                  


Ile Ser Glu Ile Trp Phe Glu Tyr Glu Gly Thr Pro Leu Lys Trp His 
65                  70                  75                  80  


Tyr Pro Ile Gly Leu Leu Phe Asp Leu Leu Ala Ser Ser Ser Ala Leu 
                85                  90                  95      


Pro Trp Asn Ile Thr Val His Phe Lys Ser Phe Pro Glu Lys Asp Leu 
            100                 105                 110         


Leu His Cys Pro Ser Lys Asp Ala Ile Glu Ala His Phe Met Ser Cys 
        115                 120                 125             


Met Lys Glu Ala Asp Ala Leu Lys His Lys Ser Gln Val Ile Asn Glu 
    130                 135                 140                 


Met Gln Lys Lys Asp His Lys Gln Leu Trp Met Gly Leu Gln Asn Asp 
145                 150                 155                 160 


Arg Phe Asp Gln Phe Trp Ala Ile Asn Arg Lys Leu Met Glu Tyr Pro 
                165                 170                 175     


Ala Glu Glu Asn Gly Phe Arg Tyr Ile Pro Phe Arg Ile Tyr Gln Thr 
            180                 185                 190         


Thr Thr Glu Arg Pro Phe Ile Gln Lys Leu Phe Arg Pro Val Ala Ala 
        195                 200                 205             


Asp Gly Gln Leu His Thr Leu Gly Asp Leu Leu Lys Glu Val Cys Pro 
    210                 215                 220                 


Ser Ala Ile Asp Pro Glu Asp Gly Glu Lys Lys Asn Gln Val Met Ile 
225                 230                 235                 240 


His Gly Ile Glu Pro Met Leu Glu Thr Pro Leu Gln Trp Leu Ser Glu 
                245                 250                 255     


His Leu Ser Tyr Pro Asp Asn Phe Leu His Ile Ser Ile Ile Pro Gln 
            260                 265                 270         


Pro Thr Asp 
        275 


<210>  1225
<211>  275
<212>  PRT
<213>  Homo Sapiens

<400>  1225

Met Thr Asp Asp Lys Asp Val Leu Arg Asp Val Trp Phe Gly Arg Ile 
1               5                   10                  15      


Pro Thr Cys Phe Thr Leu Tyr Gln Asp Glu Ile Thr Glu Arg Glu Ala 
            20                  25                  30          


Glu Pro Tyr Tyr Leu Leu Leu Pro Arg Val Ser Tyr Leu Thr Leu Val 
        35                  40                  45              


Thr Asp Lys Val Lys Lys His Phe Gln Lys Val Met Arg Gln Glu Asp 
    50                  55                  60                  


Ile Ser Glu Ile Trp Phe Glu Tyr Glu Gly Thr Pro Leu Lys Trp His 
65                  70                  75                  80  


Tyr Pro Ile Gly Leu Leu Phe Asp Leu Leu Ala Ser Ser Ser Ala Leu 
                85                  90                  95      


Pro Trp Asn Ile Thr Val His Phe Lys Ser Phe Pro Glu Lys Asp Leu 
            100                 105                 110         


Leu His Cys Pro Ser Lys Asp Ala Ile Glu Ala His Phe Met Ser Cys 
        115                 120                 125             


Met Lys Glu Ala Asp Ala Leu Lys His Lys Ser Gln Val Ile Asn Glu 
    130                 135                 140                 


Met Gln Lys Lys Asp His Lys Gln Leu Trp Met Gly Leu Gln Asn Asp 
145                 150                 155                 160 


Arg Phe Asp Gln Phe Trp Ala Ile Asn Arg Lys Leu Met Glu Tyr Pro 
                165                 170                 175     


Ala Glu Glu Asn Gly Phe Arg Tyr Ile Pro Phe Arg Ile Tyr Gln Thr 
            180                 185                 190         


Thr Thr Glu Arg Pro Phe Ile Gln Lys Leu Phe Arg Pro Val Ala Ala 
        195                 200                 205             


Asp Gly Gln Leu His Thr Leu Gly Asp Leu Leu Lys Glu Val Cys Pro 
    210                 215                 220                 


Ser Ala Ile Asp Pro Glu Asp Gly Glu Lys Lys Asn Gln Val Met Ile 
225                 230                 235                 240 


His Gly Ile Glu Pro Met Leu Glu Thr Pro Leu Gln Trp Leu Ser Glu 
                245                 250                 255     


His Leu Ser Tyr Pro Asp Asn Phe Leu His Ile Ser Ile Ile Pro Gln 
            260                 265                 270         


Pro Thr Asp 
        275 


<210>  1226
<211>  233
<212>  PRT
<213>  Homo Sapiens

<400>  1226

Met Thr Asp Asp Lys Asp Val Leu Arg Asp Val Trp Phe Gly Arg Ile 
1               5                   10                  15      


Pro Thr Cys Phe Thr Leu Tyr Gln Asp Glu Ile Thr Glu Arg Glu Ala 
            20                  25                  30          


Glu Pro Tyr Tyr Leu Leu Leu Pro Arg Val Ser Tyr Leu Thr Leu Val 
        35                  40                  45              


Thr Asp Lys Val Lys Lys His Phe Gln Lys Val Met Arg Gln Glu Asp 
    50                  55                  60                  


Ile Ser Glu Ile Trp Phe Glu Tyr Glu Gly Thr Pro Leu Lys Trp His 
65                  70                  75                  80  


Tyr Pro Ile Gly Leu Leu Phe Asp Leu Leu Ala Ser Ser Ser Ala Leu 
                85                  90                  95      


Pro Trp Asn Ile Thr Val His Phe Lys Ser Phe Pro Glu Lys Asp Leu 
            100                 105                 110         


Leu His Cys Pro Ser Lys Asp Ala Ile Glu Ala His Phe Met Ser Cys 
        115                 120                 125             


Met Lys Glu Ala Asp Ala Leu Lys His Lys Ser Gln Val Ile Asn Glu 
    130                 135                 140                 


Met Gln Lys Lys Asp His Lys Gln Leu Trp Met Gly Leu Gln Asn Asp 
145                 150                 155                 160 


Arg Phe Asp Gln Phe Trp Ala Ile Asn Arg Lys Leu Met Glu Tyr Pro 
                165                 170                 175     


Ala Glu Glu Asn Gly Phe Arg Tyr Ile Pro Phe Arg Ile Tyr Gln Val 
            180                 185                 190         


Thr Ala Val Trp Val Gly Ile Gln Arg Phe Gln Ala Ser Glu Glu Glu 
        195                 200                 205             


Ser Glu Asp Glu Glu Phe Leu Ala Thr Leu Thr Gly Gly Glu Arg Ser 
    210                 215                 220                 


Gly Lys Ala Arg Lys Gln Trp Thr Gln 
225                 230             


<210>  1227
<211>  91
<212>  PRT
<213>  Homo Sapiens

<400>  1227

Met Thr Asp Asp Lys Asp Val Leu Arg Asp Val Trp Phe Gly Arg Ile 
1               5                   10                  15      


Pro Thr Cys Phe Thr Leu Tyr Gln Asp Glu Ile Thr Glu Arg Glu Ala 
            20                  25                  30          


Glu Pro Tyr Tyr Thr Asp Leu Thr Ser Phe Gly Pro Ser Ile Gly Asn 
        35                  40                  45              


Ser Trp Asn Ile Leu Gln Lys Lys Met Asp Phe Val Ile Ser Pro Leu 
    50                  55                  60                  


Glu Tyr Ile Arg Gln Arg Leu Lys Asp Leu Ser Phe Arg Ser Cys Phe 
65                  70                  75                  80  


Val Leu Trp Leu Gln Met Asp Ser Cys Thr His 
                85                  90      


<210>  1228
<211>  823
<212>  PRT
<213>  Homo Sapiens

<400>  1228

Met Ala Ala Ser Glu Ala Ala Ala Ala Ala Gly Ser Ala Ala Leu Ala 
1               5                   10                  15      


Ala Gly Ala Arg Ala Val Pro Ala Ala Thr Thr Gly Ala Ala Ala Ala 
            20                  25                  30          


Ala Ser Gly Pro Trp Val Pro Pro Gly Pro Arg Leu Arg Gly Ser Arg 
        35                  40                  45              


Pro Arg Pro Ala Gly Ala Thr Gln Gln Pro Ala Val Pro Ala Pro Pro 
    50                  55                  60                  


Ala Gly Glu Leu Ile Gln Pro Ser Val Ser Glu Leu Ser Arg Ala Val 
65                  70                  75                  80  


Arg Thr Asn Ile Leu Cys Thr Val Arg Gly Cys Gly Lys Ile Leu Pro 
                85                  90                  95      


Asn Ser Pro Ala Leu Asn Met His Leu Val Lys Ser His Arg Leu Gln 
            100                 105                 110         


Asp Gly Ile Val Asn Pro Thr Ile Arg Lys Asp Leu Lys Thr Gly Pro 
        115                 120                 125             


Lys Phe Tyr Cys Cys Pro Ile Glu Gly Cys Pro Arg Gly Pro Glu Arg 
    130                 135                 140                 


Pro Phe Ser Gln Phe Ser Leu Val Lys Gln His Phe Met Lys Met His 
145                 150                 155                 160 


Ala Glu Lys Lys His Lys Cys Ser Lys Cys Ser Asn Ser Tyr Gly Thr 
                165                 170                 175     


Glu Trp Asp Leu Lys Arg His Ala Glu Asp Cys Gly Lys Thr Phe Arg 
            180                 185                 190         


Cys Thr Cys Gly Cys Pro Tyr Ala Ser Arg Thr Ala Leu Gln Ser His 
        195                 200                 205             


Ile Tyr Arg Thr Gly His Glu Ile Pro Ala Glu His Arg Asp Pro Pro 
    210                 215                 220                 


Ser Lys Lys Arg Lys Met Glu Asn Cys Ala Gln Asn Gln Lys Leu Ser 
225                 230                 235                 240 


Asn Lys Thr Ile Glu Ser Leu Asn Asn Gln Pro Ile Pro Arg Pro Asp 
                245                 250                 255     


Thr Gln Glu Leu Glu Ala Ser Glu Ile Lys Leu Glu Pro Ser Phe Glu 
            260                 265                 270         


Asp Ser Cys Gly Ser Asn Thr Asp Lys Gln Thr Leu Thr Thr Pro Pro 
        275                 280                 285             


Arg Tyr Pro Gln Lys Leu Leu Leu Pro Lys Pro Lys Val Ala Leu Val 
    290                 295                 300                 


Lys Leu Pro Val Met Gln Phe Ser Val Met Pro Val Phe Val Pro Thr 
305                 310                 315                 320 


Ala Asp Ser Ser Ala Gln Pro Val Val Leu Gly Val Asp Gln Gly Ser 
                325                 330                 335     


Ala Thr Gly Ala Val His Leu Met Pro Leu Ser Val Gly Thr Leu Ile 
            340                 345                 350         


Leu Gly Leu Asp Ser Glu Ala Cys Ser Leu Lys Glu Ser Leu Pro Leu 
        355                 360                 365             


Phe Lys Ile Ala Asn Pro Ile Ala Gly Glu Pro Ile Ser Thr Gly Val 
    370                 375                 380                 


Gln Val Asn Phe Gly Lys Ser Pro Ser Asn Pro Leu Gln Glu Leu Gly 
385                 390                 395                 400 


Asn Thr Cys Gln Lys Asn Ser Ile Ser Ser Ile Asn Val Gln Thr Asp 
                405                 410                 415     


Leu Ser Tyr Ala Ser Gln Asn Phe Ile Pro Ser Ala Gln Trp Ala Thr 
            420                 425                 430         


Ala Asp Ser Ser Val Ser Ser Cys Ser Gln Thr Asp Leu Ser Phe Asp 
        435                 440                 445             


Ser Gln Val Ser Leu Pro Ile Ser Val His Thr Gln Thr Phe Leu Pro 
    450                 455                 460                 


Ser Ser Lys Val Thr Ser Ser Ile Ala Ala Gln Thr Asp Ala Phe Met 
465                 470                 475                 480 


Asp Thr Cys Phe Gln Ser Gly Gly Val Ser Arg Glu Thr Gln Thr Ser 
                485                 490                 495     


Gly Ile Glu Ser Pro Thr Asp Asp His Val Gln Met Asp Gln Ala Gly 
            500                 505                 510         


Met Cys Gly Asp Ile Phe Glu Ser Val His Ser Ser Tyr Asn Val Ala 
        515                 520                 525             


Thr Gly Asn Ile Ile Ser Asn Ser Leu Val Ala Glu Thr Val Thr His 
    530                 535                 540                 


Ser Leu Leu Pro Gln Asn Glu Pro Lys Thr Leu Asn Gln Asp Ile Glu 
545                 550                 555                 560 


Lys Ser Ala Pro Ile Ile Asn Phe Ser Ala Gln Asn Ser Met Leu Pro 
                565                 570                 575     


Ser Gln Asn Met Thr Asp Asn Gln Thr Gln Thr Ile Asp Leu Leu Ser 
            580                 585                 590         


Asp Leu Glu Asn Ile Leu Ser Ser Asn Leu Pro Ala Gln Thr Leu Asp 
        595                 600                 605             


His Arg Ser Leu Leu Ser Asp Thr Asn Pro Gly Pro Asp Thr Gln Leu 
    610                 615                 620                 


Pro Ser Gly Pro Ala Gln Asn Pro Gly Ile Asp Phe Asp Ile Glu Glu 
625                 630                 635                 640 


Phe Phe Ser Ala Ser Asn Ile Gln Thr Gln Thr Glu Glu Ser Glu Leu 
                645                 650                 655     


Ser Thr Met Thr Thr Glu Pro Val Leu Glu Ser Leu Asp Ile Glu Thr 
            660                 665                 670         


Gln Thr Asp Phe Leu Leu Ala Asp Thr Ser Ala Gln Ser Tyr Gly Cys 
        675                 680                 685             


Arg Gly Asn Ser Asn Phe Leu Gly Leu Glu Met Phe Asp Thr Gln Thr 
    690                 695                 700                 


Gln Thr Asp Leu Asn Phe Phe Leu Asp Ser Ser Pro His Leu Pro Leu 
705                 710                 715                 720 


Gly Ser Ile Leu Lys His Ser Ser Phe Ser Val Ser Thr Asp Ser Ser 
                725                 730                 735     


Asp Thr Glu Thr Gln Thr Glu Gly Val Ser Thr Ala Lys Asn Ile Pro 
            740                 745                 750         


Ala Leu Glu Ser Lys Val Gln Leu Asn Ser Thr Glu Thr Gln Thr Met 
        755                 760                 765             


Ser Ser Gly Phe Glu Thr Leu Gly Ser Leu Phe Phe Thr Ser Asn Glu 
    770                 775                 780                 


Thr Gln Thr Ala Met Asp Asp Phe Leu Leu Ala Asp Leu Ala Trp Asn 
785                 790                 795                 800 


Thr Met Glu Ser Gln Phe Ser Ser Val Glu Thr Gln Thr Ser Ala Glu 
                805                 810                 815     


Pro His Thr Val Ser Asn Phe 
            820             


<210>  1229
<211>  55
<212>  PRT
<213>  Homo Sapiens

<400>  1229

Met Lys Met His Ala Glu Lys Lys His Lys Cys Ser Lys Cys Ser Asn 
1               5                   10                  15      


Ser Tyr Gly Thr Glu Trp Asp Leu Lys Arg His Ala Glu Asp Cys Gly 
            20                  25                  30          


Lys Thr Phe Arg Cys Thr Cys Gly Cys Pro Tyr Ala Ser Arg Thr Ala 
        35                  40                  45              


Leu Gln Ser His Ile Tyr Arg 
    50                  55  


<210>  1230
<211>  667
<212>  PRT
<213>  Homo Sapiens

<400>  1230

Met Lys Met His Ala Glu Lys Lys His Lys Cys Ser Lys Cys Ser Asn 
1               5                   10                  15      


Ser Tyr Gly Thr Glu Trp Asp Leu Lys Arg His Ala Glu Asp Cys Gly 
            20                  25                  30          


Lys Thr Phe Arg Cys Thr Cys Gly Cys Pro Tyr Ala Ser Arg Thr Ala 
        35                  40                  45              


Leu Gln Ser His Ile Tyr Arg Thr Gly His Glu Ile Pro Ala Glu His 
    50                  55                  60                  


Arg Asp Pro Pro Ser Lys Lys Arg Lys Met Glu Asn Cys Ala Gln Asn 
65                  70                  75                  80  


Gln Lys Leu Ser Asn Lys Thr Ile Glu Ser Leu Asn Asn Gln Pro Ile 
                85                  90                  95      


Pro Arg Pro Asp Thr Gln Glu Leu Glu Ala Ser Glu Ile Lys Leu Glu 
            100                 105                 110         


Pro Ser Phe Glu Asp Ser Cys Gly Ser Asn Thr Asp Lys Gln Thr Leu 
        115                 120                 125             


Thr Thr Pro Pro Arg Tyr Pro Gln Lys Leu Leu Leu Pro Lys Pro Lys 
    130                 135                 140                 


Val Ala Leu Val Lys Leu Pro Val Met Gln Phe Ser Val Met Pro Val 
145                 150                 155                 160 


Phe Val Pro Thr Ala Asp Ser Ser Ala Gln Pro Val Val Leu Gly Val 
                165                 170                 175     


Asp Gln Gly Ser Ala Thr Gly Ala Val His Leu Met Pro Leu Ser Val 
            180                 185                 190         


Gly Thr Leu Ile Leu Gly Leu Asp Ser Glu Ala Cys Ser Leu Lys Glu 
        195                 200                 205             


Ser Leu Pro Leu Phe Lys Ile Ala Asn Pro Ile Ala Gly Glu Pro Ile 
    210                 215                 220                 


Ser Thr Gly Val Gln Val Asn Phe Gly Lys Ser Pro Ser Asn Pro Leu 
225                 230                 235                 240 


Gln Glu Leu Gly Asn Thr Cys Gln Lys Asn Ser Ile Ser Ser Ile Asn 
                245                 250                 255     


Val Gln Thr Asp Leu Ser Tyr Ala Ser Gln Asn Phe Ile Pro Ser Ala 
            260                 265                 270         


Gln Trp Ala Thr Ala Asp Ser Ser Val Ser Ser Cys Ser Gln Thr Asp 
        275                 280                 285             


Leu Ser Phe Asp Ser Gln Val Ser Leu Pro Ile Ser Val His Thr Gln 
    290                 295                 300                 


Thr Phe Leu Pro Ser Ser Lys Val Thr Ser Ser Ile Ala Ala Gln Thr 
305                 310                 315                 320 


Asp Ala Phe Met Asp Thr Cys Phe Gln Ser Gly Gly Val Ser Arg Glu 
                325                 330                 335     


Thr Gln Thr Ser Gly Ile Glu Ser Pro Thr Asp Asp His Val Gln Met 
            340                 345                 350         


Asp Gln Ala Gly Met Cys Gly Asp Ile Phe Glu Ser Val His Ser Ser 
        355                 360                 365             


Tyr Asn Val Ala Thr Gly Asn Ile Ile Ser Asn Ser Leu Val Ala Glu 
    370                 375                 380                 


Thr Val Thr His Ser Leu Leu Pro Gln Asn Glu Pro Lys Thr Leu Asn 
385                 390                 395                 400 


Gln Asp Ile Glu Lys Ser Ala Pro Ile Ile Asn Phe Ser Ala Gln Asn 
                405                 410                 415     


Ser Met Leu Pro Ser Gln Asn Met Thr Asp Asn Gln Thr Gln Thr Ile 
            420                 425                 430         


Asp Leu Leu Ser Asp Leu Glu Asn Ile Leu Ser Ser Asn Leu Pro Ala 
        435                 440                 445             


Gln Thr Leu Asp His Arg Ser Leu Leu Ser Asp Thr Asn Pro Gly Pro 
    450                 455                 460                 


Asp Thr Gln Leu Pro Ser Gly Pro Ala Gln Asn Pro Gly Ile Asp Phe 
465                 470                 475                 480 


Asp Ile Glu Glu Phe Phe Ser Ala Ser Asn Ile Gln Thr Gln Thr Glu 
                485                 490                 495     


Glu Ser Glu Leu Ser Thr Met Thr Thr Glu Pro Val Leu Glu Ser Leu 
            500                 505                 510         


Asp Ile Glu Thr Gln Thr Asp Phe Leu Leu Ala Asp Thr Ser Ala Gln 
        515                 520                 525             


Ser Tyr Gly Cys Arg Gly Asn Ser Asn Phe Leu Gly Leu Glu Met Phe 
    530                 535                 540                 


Asp Thr Gln Thr Gln Thr Asp Leu Asn Phe Phe Leu Asp Ser Ser Pro 
545                 550                 555                 560 


His Leu Pro Leu Gly Ser Ile Leu Lys His Ser Ser Phe Ser Val Ser 
                565                 570                 575     


Thr Asp Ser Ser Asp Thr Glu Thr Gln Thr Glu Gly Val Ser Thr Ala 
            580                 585                 590         


Lys Asn Ile Pro Ala Leu Glu Ser Lys Val Gln Leu Asn Ser Thr Glu 
        595                 600                 605             


Thr Gln Thr Met Ser Ser Gly Phe Glu Thr Leu Gly Ser Leu Phe Phe 
    610                 615                 620                 


Thr Ser Asn Glu Thr Gln Thr Ala Met Asp Asp Phe Leu Leu Ala Asp 
625                 630                 635                 640 


Leu Ala Trp Asn Thr Met Glu Ser Gln Phe Ser Ser Val Glu Thr Gln 
                645                 650                 655     


Thr Ser Ala Glu Pro His Thr Val Ser Asn Phe 
            660                 665         


<210>  1231
<211>  667
<212>  PRT
<213>  Homo Sapiens

<400>  1231

Met Lys Met His Ala Glu Lys Lys His Lys Cys Ser Lys Cys Ser Asn 
1               5                   10                  15      


Ser Tyr Gly Thr Glu Trp Asp Leu Lys Arg His Ala Glu Asp Cys Gly 
            20                  25                  30          


Lys Thr Phe Arg Cys Thr Cys Gly Cys Pro Tyr Ala Ser Arg Thr Ala 
        35                  40                  45              


Leu Gln Ser His Ile Tyr Arg Thr Gly His Glu Ile Pro Ala Glu His 
    50                  55                  60                  


Arg Asp Pro Pro Ser Lys Lys Arg Lys Met Glu Asn Cys Ala Gln Asn 
65                  70                  75                  80  


Gln Lys Leu Ser Asn Lys Thr Ile Glu Ser Leu Asn Asn Gln Pro Ile 
                85                  90                  95      


Pro Arg Pro Asp Thr Gln Glu Leu Glu Ala Ser Glu Ile Lys Leu Glu 
            100                 105                 110         


Pro Ser Phe Glu Asp Ser Cys Gly Ser Asn Thr Asp Lys Gln Thr Leu 
        115                 120                 125             


Thr Thr Pro Pro Arg Tyr Pro Gln Lys Leu Leu Leu Pro Lys Pro Lys 
    130                 135                 140                 


Val Ala Leu Val Lys Leu Pro Val Met Gln Phe Ser Val Met Pro Val 
145                 150                 155                 160 


Phe Val Pro Thr Ala Asp Ser Ser Ala Gln Pro Val Val Leu Gly Val 
                165                 170                 175     


Asp Gln Gly Ser Ala Thr Gly Ala Val His Leu Met Pro Leu Ser Val 
            180                 185                 190         


Gly Thr Leu Ile Leu Gly Leu Asp Ser Glu Ala Cys Ser Leu Lys Glu 
        195                 200                 205             


Ser Leu Pro Leu Phe Lys Ile Ala Asn Pro Ile Ala Gly Glu Pro Ile 
    210                 215                 220                 


Ser Thr Gly Val Gln Val Asn Phe Gly Lys Ser Pro Ser Asn Pro Leu 
225                 230                 235                 240 


Gln Glu Leu Gly Asn Thr Cys Gln Lys Asn Ser Ile Ser Ser Ile Asn 
                245                 250                 255     


Val Gln Thr Asp Leu Ser Tyr Ala Ser Gln Asn Phe Ile Pro Ser Ala 
            260                 265                 270         


Gln Trp Ala Thr Ala Asp Ser Ser Val Ser Ser Cys Ser Gln Thr Asp 
        275                 280                 285             


Leu Ser Phe Asp Ser Gln Val Ser Leu Pro Ile Ser Val His Thr Gln 
    290                 295                 300                 


Thr Phe Leu Pro Ser Ser Lys Val Thr Ser Ser Ile Ala Ala Gln Thr 
305                 310                 315                 320 


Asp Ala Phe Met Asp Thr Cys Phe Gln Ser Gly Gly Val Ser Arg Glu 
                325                 330                 335     


Thr Gln Thr Ser Gly Ile Glu Ser Pro Thr Asp Asp His Val Gln Met 
            340                 345                 350         


Asp Gln Ala Gly Met Cys Gly Asp Ile Phe Glu Ser Val His Ser Ser 
        355                 360                 365             


Tyr Asn Val Ala Thr Gly Asn Ile Ile Ser Asn Ser Leu Val Ala Glu 
    370                 375                 380                 


Thr Val Thr His Ser Leu Leu Pro Gln Asn Glu Pro Lys Thr Leu Asn 
385                 390                 395                 400 


Gln Asp Ile Glu Lys Ser Ala Pro Ile Ile Asn Phe Ser Ala Gln Asn 
                405                 410                 415     


Ser Met Leu Pro Ser Gln Asn Met Thr Asp Asn Gln Thr Gln Thr Ile 
            420                 425                 430         


Asp Leu Leu Ser Asp Leu Glu Asn Ile Leu Ser Ser Asn Leu Pro Ala 
        435                 440                 445             


Gln Thr Leu Asp His Arg Ser Leu Leu Ser Asp Thr Asn Pro Gly Pro 
    450                 455                 460                 


Asp Thr Gln Leu Pro Ser Gly Pro Ala Gln Asn Pro Gly Ile Asp Phe 
465                 470                 475                 480 


Asp Ile Glu Glu Phe Phe Ser Ala Ser Asn Ile Gln Thr Gln Thr Glu 
                485                 490                 495     


Glu Ser Glu Leu Ser Thr Met Thr Thr Glu Pro Val Leu Glu Ser Leu 
            500                 505                 510         


Asp Ile Glu Thr Gln Thr Asp Phe Leu Leu Ala Asp Thr Ser Ala Gln 
        515                 520                 525             


Ser Tyr Gly Cys Arg Gly Asn Ser Asn Phe Leu Gly Leu Glu Met Phe 
    530                 535                 540                 


Asp Thr Gln Thr Gln Thr Asp Leu Asn Phe Phe Leu Asp Ser Ser Pro 
545                 550                 555                 560 


His Leu Pro Leu Gly Ser Ile Leu Lys His Ser Ser Phe Ser Val Ser 
                565                 570                 575     


Thr Asp Ser Ser Asp Thr Glu Thr Gln Thr Glu Gly Val Ser Thr Ala 
            580                 585                 590         


Lys Asn Ile Pro Ala Leu Glu Ser Lys Val Gln Leu Asn Ser Thr Glu 
        595                 600                 605             


Thr Gln Thr Met Ser Ser Gly Phe Glu Thr Leu Gly Ser Leu Phe Phe 
    610                 615                 620                 


Thr Ser Asn Glu Thr Gln Thr Ala Met Asp Asp Phe Leu Leu Ala Asp 
625                 630                 635                 640 


Leu Ala Trp Asn Thr Met Glu Ser Gln Phe Ser Ser Val Glu Thr Gln 
                645                 650                 655     


Thr Ser Ala Glu Pro His Thr Val Ser Asn Phe 
            660                 665         


<210>  1232
<211>  1204
<212>  PRT
<213>  Homo Sapiens

<400>  1232

Met Ala Ala Ala Ala Ala Val Gly Asn Ala Val Pro Cys Gly Ala Arg 
1               5                   10                  15      


Pro Cys Gly Val Arg Pro Asp Gly Gln Pro Lys Pro Gly Pro Gln Pro 
            20                  25                  30          


Arg Ala Leu Leu Ala Ala Gly Pro Ala Leu Ile Ala Asn Gly Asp Glu 
        35                  40                  45              


Leu Val Ala Ala Val Trp Pro Tyr Arg Arg Leu Ala Leu Leu Arg Arg 
    50                  55                  60                  


Leu Thr Val Leu Pro Phe Ala Gly Leu Leu Tyr Pro Ala Trp Leu Gly 
65                  70                  75                  80  


Ala Ala Ala Ala Gly Cys Trp Gly Trp Gly Ser Ser Trp Val Gln Ile 
                85                  90                  95      


Pro Glu Ala Ala Leu Leu Val Leu Ala Thr Ile Cys Leu Ala His Ala 
            100                 105                 110         


Leu Thr Val Leu Ser Gly His Trp Ser Val His Ala His Cys Ala Leu 
        115                 120                 125             


Thr Cys Thr Pro Glu Tyr Asp Pro Ser Lys Ala Thr Phe Val Lys Val 
    130                 135                 140                 


Val Pro Thr Pro Asn Asn Gly Ser Thr Glu Leu Val Ala Leu His Arg 
145                 150                 155                 160 


Asn Glu Gly Glu Asp Gly Leu Glu Val Leu Ser Phe Glu Phe Gln Lys 
                165                 170                 175     


Ile Lys Tyr Ser Tyr Asp Ala Leu Glu Lys Lys Gln Phe Leu Pro Val 
            180                 185                 190         


Ala Phe Pro Val Gly Asn Ala Phe Ser Tyr Tyr Gln Ser Asn Arg Gly 
        195                 200                 205             


Phe Gln Glu Asp Ser Glu Ile Arg Ala Ala Glu Lys Lys Phe Gly Ser 
    210                 215                 220                 


Asn Lys Ala Glu Met Val Val Pro Asp Phe Ser Glu Leu Phe Lys Glu 
225                 230                 235                 240 


Arg Ala Thr Ala Pro Phe Phe Val Phe Gln Val Phe Cys Val Gly Leu 
                245                 250                 255     


Trp Cys Leu Asp Glu Tyr Trp Tyr Tyr Ser Val Phe Thr Leu Ser Met 
            260                 265                 270         


Leu Val Ala Phe Glu Ala Ser Leu Val Gln Gln Gln Met Arg Asn Met 
        275                 280                 285             


Ser Glu Ile Arg Lys Met Gly Asn Lys Pro His Met Ile Gln Val Tyr 
    290                 295                 300                 


Arg Ser Arg Lys Trp Arg Pro Ile Ala Ser Asp Glu Ile Val Pro Gly 
305                 310                 315                 320 


Asp Ile Val Ser Ile Gly Arg Ser Pro Gln Glu Asn Leu Val Pro Cys 
                325                 330                 335     


Asp Val Leu Leu Leu Arg Gly Arg Cys Ile Val Asp Glu Ala Met Leu 
            340                 345                 350         


Thr Gly Glu Ser Val Pro Gln Met Lys Glu Pro Ile Glu Asp Leu Ser 
        355                 360                 365             


Pro Asp Arg Val Leu Asp Leu Gln Ala Asp Ser Arg Leu His Val Ile 
    370                 375                 380                 


Phe Gly Gly Thr Lys Val Val Gln His Ile Pro Pro Gln Lys Ala Thr 
385                 390                 395                 400 


Thr Gly Leu Lys Pro Val Asp Ser Gly Cys Val Ala Tyr Val Leu Arg 
                405                 410                 415     


Thr Gly Phe Asn Thr Ser Gln Gly Lys Leu Leu Arg Thr Ile Leu Phe 
            420                 425                 430         


Gly Val Lys Arg Val Thr Ala Asn Asn Leu Glu Thr Phe Ile Phe Ile 
        435                 440                 445             


Leu Phe Leu Leu Val Phe Ala Ile Ala Ala Ala Ala Tyr Val Trp Ile 
    450                 455                 460                 


Glu Gly Thr Lys Asp Pro Ser Arg Asn Arg Tyr Lys Leu Phe Leu Glu 
465                 470                 475                 480 


Cys Thr Leu Ile Leu Thr Ser Val Val Pro Pro Glu Leu Pro Ile Glu 
                485                 490                 495     


Leu Ser Leu Ala Val Asn Thr Ser Leu Ile Ala Leu Ala Lys Leu Tyr 
            500                 505                 510         


Met Tyr Cys Thr Glu Pro Phe Arg Ile Pro Phe Ala Gly Lys Val Glu 
        515                 520                 525             


Val Cys Cys Phe Asp Lys Thr Gly Thr Leu Thr Ser Asp Ser Leu Val 
    530                 535                 540                 


Val Arg Gly Val Ala Gly Leu Arg Asp Gly Lys Glu Val Thr Pro Val 
545                 550                 555                 560 


Ser Ser Ile Pro Val Glu Thr His Arg Ala Leu Ala Ser Cys His Ser 
                565                 570                 575     


Leu Met Gln Leu Asp Asp Gly Thr Leu Val Gly Asp Pro Leu Glu Lys 
            580                 585                 590         


Ala Met Leu Thr Ala Val Asp Trp Thr Leu Thr Lys Asp Glu Lys Val 
        595                 600                 605             


Phe Pro Arg Ser Ile Lys Thr Gln Gly Leu Lys Ile His Gln Arg Phe 
    610                 615                 620                 


His Phe Ala Ser Ala Leu Lys Arg Met Ser Val Leu Ala Ser Tyr Glu 
625                 630                 635                 640 


Lys Leu Gly Ser Thr Asp Leu Cys Tyr Ile Ala Ala Val Lys Gly Ala 
                645                 650                 655     


Pro Glu Thr Leu His Ser Met Phe Ser Gln Cys Pro Pro Asp Tyr His 
            660                 665                 670         


His Ile His Thr Glu Ile Ser Arg Glu Gly Ala Arg Val Leu Ala Leu 
        675                 680                 685             


Gly Tyr Lys Glu Leu Gly His Leu Thr His Gln Gln Ala Arg Glu Val 
    690                 695                 700                 


Lys Arg Glu Ala Leu Glu Cys Ser Leu Lys Phe Val Gly Phe Ile Val 
705                 710                 715                 720 


Val Ser Cys Pro Leu Lys Ala Asp Ser Lys Ala Val Ile Arg Glu Ile 
                725                 730                 735     


Gln Asn Ala Ser His Arg Val Val Met Ile Thr Gly Asp Asn Pro Leu 
            740                 745                 750         


Thr Ala Cys His Val Ala Gln Glu Leu His Phe Ile Glu Lys Ala His 
        755                 760                 765             


Thr Leu Ile Leu Gln Pro Pro Ser Glu Lys Gly Arg Gln Cys Glu Trp 
    770                 775                 780                 


Arg Ser Ile Asp Gly Ser Ile Val Leu Pro Leu Ala Arg Gly Ser Pro 
785                 790                 795                 800 


Lys Ala Leu Ala Leu Glu Tyr Ala Leu Cys Leu Thr Gly Asp Gly Leu 
                805                 810                 815     


Ala His Leu Gln Ala Thr Asp Pro Gln Gln Leu Leu Arg Leu Ile Pro 
            820                 825                 830         


His Val Gln Val Phe Ala Arg Val Ala Pro Lys Gln Lys Glu Phe Val 
        835                 840                 845             


Ile Thr Ser Leu Lys Glu Leu Gly Tyr Val Thr Leu Met Cys Gly Asp 
    850                 855                 860                 


Gly Thr Asn Asp Val Gly Ala Leu Lys His Ala Asp Val Gly Val Ala 
865                 870                 875                 880 


Leu Leu Ala Asn Ala Pro Glu Arg Val Val Glu Arg Arg Arg Arg Pro 
                885                 890                 895     


Arg Asp Ser Pro Thr Leu Ser Asn Ser Gly Ile Arg Ala Thr Ser Arg 
            900                 905                 910         


Thr Ala Lys Gln Arg Ser Gly Leu Pro Pro Ser Glu Glu Gln Pro Thr 
        915                 920                 925             


Ser Gln Arg Asp Arg Leu Ser Gln Val Leu Arg Asp Leu Glu Asp Glu 
    930                 935                 940                 


Ser Thr Pro Ile Val Lys Leu Gly Asp Ala Ser Ile Ala Ala Pro Phe 
945                 950                 955                 960 


Thr Ser Lys Leu Ser Ser Ile Gln Cys Ile Cys His Val Ile Lys Gln 
                965                 970                 975     


Gly Arg Cys Thr Leu Val Thr Thr Leu Gln Met Phe Lys Ile Leu Ala 
            980                 985                 990         


Leu Asn Ala Leu Ile Leu Ala Tyr  Ser Gln Ser Val Leu  Tyr Leu Glu 
        995                 1000                 1005             


Gly Val  Lys Phe Ser Asp Phe  Gln Ala Thr Leu Gln  Gly Leu Leu 
    1010                 1015                 1020             


Leu Ala  Gly Cys Phe Leu Phe  Ile Ser Arg Ser Lys  Pro Leu Lys 
    1025                 1030                 1035             


Thr Leu  Ser Arg Glu Arg Pro  Leu Pro Asn Ile Phe  Asn Leu Tyr 
    1040                 1045                 1050             


Thr Ile  Leu Thr Val Met Leu  Gln Phe Phe Val His  Phe Leu Ser 
    1055                 1060                 1065             


Leu Val  Tyr Leu Tyr Arg Glu  Ala Gln Ala Arg Ser  Pro Glu Lys 
    1070                 1075                 1080             


Gln Glu  Gln Phe Val Asp Leu  Tyr Lys Glu Phe Glu  Pro Ser Leu 
    1085                 1090                 1095             


Val Asn  Ser Thr Val Tyr Ile  Met Ala Met Ala Met  Gln Met Ala 
    1100                 1105                 1110             


Thr Phe  Ala Ile Asn Tyr Lys  Gly Pro Pro Phe Met  Glu Ser Leu 
    1115                 1120                 1125             


Pro Glu  Asn Lys Pro Leu Val  Trp Ser Leu Ala Val  Ser Leu Leu 
    1130                 1135                 1140             


Ala Ile  Ile Gly Leu Leu Leu  Gly Ser Ser Pro Asp  Phe Asn Ser 
    1145                 1150                 1155             


Gln Phe  Gly Leu Val Asp Ile  Pro Val Glu Phe Lys  Leu Val Ile 
    1160                 1165                 1170             


Ala Gln  Val Leu Leu Leu Asp  Phe Cys Leu Ala Leu  Leu Ala Asp 
    1175                 1180                 1185             


Arg Val  Leu Gln Phe Phe Leu  Gly Thr Pro Lys Leu  Lys Val Pro 
    1190                 1195                 1200             


Ser 
    


<210>  1233
<211>  1086
<212>  PRT
<213>  Homo Sapiens

<400>  1233

Met Glu Lys Trp Glu Glu Leu Asn Ser His Gln Pro Gly Glu Glu Tyr 
1               5                   10                  15      


Asp Pro Ser Lys Ala Thr Phe Val Lys Val Val Pro Thr Pro Asn Asn 
            20                  25                  30          


Gly Ser Thr Glu Leu Val Ala Leu His Arg Asn Glu Gly Glu Asp Gly 
        35                  40                  45              


Leu Glu Val Leu Ser Phe Glu Phe Gln Lys Ile Lys Tyr Ser Tyr Asp 
    50                  55                  60                  


Ala Leu Glu Lys Lys Gln Phe Leu Pro Val Ala Phe Pro Val Gly Asn 
65                  70                  75                  80  


Ala Phe Ser Tyr Tyr Gln Ser Asn Arg Gly Phe Gln Glu Asp Ser Glu 
                85                  90                  95      


Ile Arg Ala Ala Glu Lys Lys Phe Gly Ser Asn Lys Ala Glu Met Val 
            100                 105                 110         


Val Pro Asp Phe Ser Glu Leu Phe Lys Glu Arg Ala Thr Ala Pro Phe 
        115                 120                 125             


Phe Val Phe Gln Val Phe Cys Val Gly Leu Trp Cys Leu Asp Glu Tyr 
    130                 135                 140                 


Trp Tyr Tyr Ser Val Phe Thr Leu Ser Met Leu Val Ala Phe Glu Ala 
145                 150                 155                 160 


Ser Leu Val Gln Gln Gln Met Arg Asn Met Ser Glu Ile Arg Lys Met 
                165                 170                 175     


Gly Asn Lys Pro His Met Ile Gln Val Tyr Arg Ser Arg Lys Trp Arg 
            180                 185                 190         


Pro Ile Ala Ser Asp Glu Ile Val Pro Gly Asp Ile Val Ser Ile Gly 
        195                 200                 205             


Arg Ser Pro Gln Glu Asn Leu Val Pro Cys Asp Val Leu Leu Leu Arg 
    210                 215                 220                 


Gly Arg Cys Ile Val Asp Glu Ala Met Leu Thr Gly Glu Ser Val Pro 
225                 230                 235                 240 


Gln Met Lys Glu Pro Ile Glu Asp Leu Ser Pro Asp Arg Val Leu Asp 
                245                 250                 255     


Leu Gln Ala Asp Ser Arg Leu His Val Ile Phe Gly Gly Thr Lys Val 
            260                 265                 270         


Val Gln His Ile Pro Pro Gln Lys Ala Thr Thr Gly Leu Lys Pro Val 
        275                 280                 285             


Asp Ser Gly Cys Val Ala Tyr Val Leu Arg Thr Gly Phe Asn Thr Ser 
    290                 295                 300                 


Gln Gly Lys Leu Leu Arg Thr Ile Leu Phe Gly Val Lys Arg Val Thr 
305                 310                 315                 320 


Ala Asn Asn Leu Glu Thr Phe Ile Phe Ile Leu Phe Leu Leu Val Phe 
                325                 330                 335     


Ala Ile Ala Ala Ala Ala Tyr Val Trp Ile Glu Gly Thr Lys Asp Pro 
            340                 345                 350         


Ser Arg Asn Arg Tyr Lys Leu Phe Leu Glu Cys Thr Leu Ile Leu Thr 
        355                 360                 365             


Ser Val Val Pro Pro Glu Leu Pro Ile Glu Leu Ser Leu Ala Val Asn 
    370                 375                 380                 


Thr Ser Leu Ile Ala Leu Ala Lys Leu Tyr Met Tyr Cys Thr Glu Pro 
385                 390                 395                 400 


Phe Arg Ile Pro Phe Ala Gly Lys Val Glu Val Cys Cys Phe Asp Lys 
                405                 410                 415     


Thr Gly Thr Leu Thr Ser Asp Ser Leu Val Val Arg Gly Val Ala Gly 
            420                 425                 430         


Leu Arg Asp Gly Lys Glu Val Thr Pro Val Ser Ser Ile Pro Val Glu 
        435                 440                 445             


Thr His Arg Ala Leu Ala Ser Cys His Ser Leu Met Gln Leu Asp Asp 
    450                 455                 460                 


Gly Thr Leu Val Gly Asp Pro Leu Glu Lys Ala Met Leu Thr Ala Val 
465                 470                 475                 480 


Asp Trp Thr Leu Thr Lys Asp Glu Lys Val Phe Pro Arg Ser Ile Lys 
                485                 490                 495     


Thr Gln Gly Leu Lys Ile His Gln Arg Phe His Phe Ala Ser Ala Leu 
            500                 505                 510         


Lys Arg Met Ser Val Leu Ala Ser Tyr Glu Lys Leu Gly Ser Thr Asp 
        515                 520                 525             


Leu Cys Tyr Ile Ala Ala Val Lys Gly Ala Pro Glu Thr Leu His Ser 
    530                 535                 540                 


Met Phe Ser Gln Cys Pro Pro Asp Tyr His His Ile His Thr Glu Ile 
545                 550                 555                 560 


Ser Arg Glu Gly Ala Arg Val Leu Ala Leu Gly Tyr Lys Glu Leu Gly 
                565                 570                 575     


His Leu Thr His Gln Gln Ala Arg Glu Val Lys Arg Glu Ala Leu Glu 
            580                 585                 590         


Cys Ser Leu Lys Phe Val Gly Phe Ile Val Val Ser Cys Pro Leu Lys 
        595                 600                 605             


Ala Asp Ser Lys Ala Val Ile Arg Glu Ile Gln Asn Ala Ser His Arg 
    610                 615                 620                 


Val Val Met Ile Thr Gly Asp Asn Pro Leu Thr Ala Cys His Val Ala 
625                 630                 635                 640 


Gln Glu Leu His Phe Ile Glu Lys Ala His Thr Leu Ile Leu Gln Pro 
                645                 650                 655     


Pro Ser Glu Lys Gly Arg Gln Cys Glu Trp Arg Ser Ile Asp Gly Ser 
            660                 665                 670         


Ile Val Leu Pro Leu Ala Arg Gly Ser Pro Lys Ala Leu Ala Leu Glu 
        675                 680                 685             


Tyr Ala Leu Cys Leu Thr Gly Asp Gly Leu Ala His Leu Gln Ala Thr 
    690                 695                 700                 


Asp Pro Gln Gln Leu Leu Arg Leu Ile Pro His Val Gln Val Phe Ala 
705                 710                 715                 720 


Arg Val Ala Pro Lys Gln Lys Glu Phe Val Ile Thr Ser Leu Lys Glu 
                725                 730                 735     


Leu Gly Tyr Val Thr Leu Met Cys Gly Asp Gly Thr Asn Asp Val Gly 
            740                 745                 750         


Ala Leu Lys His Ala Asp Val Gly Val Ala Leu Leu Ala Asn Ala Pro 
        755                 760                 765             


Glu Arg Val Val Glu Arg Arg Arg Arg Pro Arg Asp Ser Pro Thr Leu 
    770                 775                 780                 


Ser Asn Ser Gly Ile Arg Ala Thr Ser Arg Thr Ala Lys Gln Arg Ser 
785                 790                 795                 800 


Gly Leu Pro Pro Ser Glu Glu Gln Pro Thr Ser Gln Arg Asp Arg Leu 
                805                 810                 815     


Ser Gln Val Leu Arg Asp Leu Glu Asp Glu Ser Thr Pro Ile Val Lys 
            820                 825                 830         


Leu Gly Asp Ala Ser Ile Ala Ala Pro Phe Thr Ser Lys Leu Ser Ser 
        835                 840                 845             


Ile Gln Cys Ile Cys His Val Ile Lys Gln Gly Arg Cys Thr Leu Val 
    850                 855                 860                 


Thr Thr Leu Gln Met Phe Lys Ile Leu Ala Leu Asn Ala Leu Ile Leu 
865                 870                 875                 880 


Ala Tyr Ser Gln Ser Val Leu Tyr Leu Glu Gly Val Lys Phe Ser Asp 
                885                 890                 895     


Phe Gln Ala Thr Leu Gln Gly Leu Leu Leu Ala Gly Cys Phe Leu Phe 
            900                 905                 910         


Ile Ser Arg Ser Lys Pro Leu Lys Thr Leu Ser Arg Glu Arg Pro Leu 
        915                 920                 925             


Pro Asn Ile Phe Asn Leu Tyr Thr Ile Leu Thr Val Met Leu Gln Phe 
    930                 935                 940                 


Phe Val His Phe Leu Ser Leu Val Tyr Leu Tyr Arg Glu Ala Gln Ala 
945                 950                 955                 960 


Arg Ser Pro Glu Lys Gln Glu Gln Phe Val Asp Leu Tyr Lys Glu Phe 
                965                 970                 975     


Glu Pro Ser Leu Val Asn Ser Thr Val Tyr Ile Met Ala Met Ala Met 
            980                 985                 990         


Gln Met Ala Thr Phe Ala Ile Asn  Tyr Lys Gly Pro Pro  Phe Met Glu 
        995                 1000                 1005             


Ser Leu  Pro Glu Asn Lys Pro  Leu Val Trp Ser Leu  Ala Val Ser 
    1010                 1015                 1020             


Leu Leu  Ala Ile Ile Gly Leu  Leu Leu Gly Ser Ser  Pro Asp Phe 
    1025                 1030                 1035             


Asn Ser  Gln Phe Gly Leu Val  Asp Ile Pro Val Glu  Phe Lys Leu 
    1040                 1045                 1050             


Val Ile  Ala Gln Val Leu Leu  Leu Asp Phe Cys Leu  Ala Leu Leu 
    1055                 1060                 1065             


Ala Asp  Arg Val Leu Gln Phe  Phe Leu Gly Thr Pro  Lys Leu Lys 
    1070                 1075                 1080             


Val Pro  Ser 
    1085     


<210>  1234
<211>  185
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1234

Xaa Ala Ser Pro Trp Val Pro Ala Ala Ala Phe Leu Ser Val Thr Ile 
1               5                   10                  15      


Ala Thr Trp Ala Thr His Leu Pro Gly Leu Asp Ser Gln Gly His Pro 
            20                  25                  30          


Leu His Phe Gly Ala Gly Leu Ile Met Thr Pro Leu Leu Thr Cys Cys 
        35                  40                  45              


Ala Cys Leu Glu Tyr Asp Pro Ser Lys Ala Thr Phe Val Lys Val Val 
    50                  55                  60                  


Pro Thr Pro Asn Asn Gly Ser Thr Glu Leu Val Ala Leu His Arg Asn 
65                  70                  75                  80  


Glu Gly Glu Asp Gly Leu Glu Val Leu Ser Phe Glu Phe Gln Lys Ile 
                85                  90                  95      


Lys Tyr Ser Tyr Asp Ala Leu Glu Lys Lys Gln Phe Leu Pro Val Ala 
            100                 105                 110         


Phe Pro Val Gly Asn Ala Phe Ser Tyr Tyr Gln Ser Asn Arg Gly Phe 
        115                 120                 125             


Gln Glu Asp Ser Glu Ile Arg Ala Ala Glu Lys Lys Phe Gly Ser Asn 
    130                 135                 140                 


Lys Ala Glu Met Val Val Pro Asp Phe Ser Glu Leu Phe Lys Glu Arg 
145                 150                 155                 160 


Ala Thr Ala Pro Phe Phe Val Phe Gln Val Phe Cys Val Gly Leu Trp 
                165                 170                 175     


Cys Leu Asp Glu Tyr Trp Tyr Tyr Ser 
            180                 185 


<210>  1235
<211>  256
<212>  PRT
<213>  Homo Sapiens

<400>  1235

Met Leu Ser Arg Val Val Leu Ser Ala Ala Ala Thr Ala Ala Pro Ser 
1               5                   10                  15      


Leu Lys Asn Ala Ala Phe Leu Gly Pro Gly Val Leu Gln Ala Thr Arg 
            20                  25                  30          


Thr Phe His Thr Gly Gln Pro His Leu Val Pro Val Pro Pro Leu Pro 
        35                  40                  45              


Glu Tyr Gly Gly Lys Val Arg Tyr Gly Leu Ile Pro Glu Glu Phe Phe 
    50                  55                  60                  


Gln Phe Leu Tyr Pro Lys Thr Gly Val Thr Gly Pro Tyr Val Leu Gly 
65                  70                  75                  80  


Thr Gly Leu Ile Leu Tyr Ala Leu Ser Lys Glu Ile Tyr Val Ile Ser 
                85                  90                  95      


Ala Glu Thr Phe Thr Ala Leu Ser Val Leu Gly Val Met Val Tyr Gly 
            100                 105                 110         


Ile Lys Lys Tyr Gly Pro Phe Val Ala Asp Phe Ala Asp Lys Leu Asn 
        115                 120                 125             


Glu Gln Lys Leu Ala Gln Leu Glu Glu Ala Lys Gln Ala Ser Ile Gln 
    130                 135                 140                 


His Ile Gln Asn Ala Ile Asp Thr Glu Lys Ser Gln Gln Ala Leu Val 
145                 150                 155                 160 


Gln Lys Arg His Tyr Leu Phe Asp Val Gln Arg Asn Asn Ile Ala Met 
                165                 170                 175     


Ala Leu Glu Val Thr Tyr Arg Glu Arg Leu Tyr Arg Val Tyr Lys Glu 
            180                 185                 190         


Val Lys Asn Arg Leu Asp Tyr His Ile Ser Val Gln Asn Met Met Arg 
        195                 200                 205             


Arg Lys Glu Gln Glu His Met Ile Asn Trp Val Glu Lys His Val Val 
    210                 215                 220                 


Gln Ser Ile Ser Thr Gln Gln Glu Lys Glu Thr Ile Ala Lys Cys Ile 
225                 230                 235                 240 


Ala Asp Leu Lys Leu Leu Ala Lys Lys Ala Gln Ala Gln Pro Val Met 
                245                 250                 255     


<210>  1236
<211>  195
<212>  PRT
<213>  Homo Sapiens

<400>  1236

Met Leu Ser Arg Val Val Leu Ser Ala Ala Ala Thr Ala Gly Pro Tyr 
1               5                   10                  15      


Val Leu Gly Thr Gly Leu Ile Leu Tyr Ala Leu Ser Lys Glu Ile Tyr 
            20                  25                  30          


Val Ile Ser Ala Glu Thr Phe Thr Ala Leu Ser Val Leu Gly Val Met 
        35                  40                  45              


Val Tyr Gly Ile Lys Lys Tyr Gly Pro Phe Val Ala Asp Phe Ala Asp 
    50                  55                  60                  


Lys Leu Asn Glu Gln Lys Leu Ala Gln Leu Glu Glu Ala Lys Gln Ala 
65                  70                  75                  80  


Ser Ile Gln His Ile Gln Asn Ala Ile Asp Thr Glu Lys Ser Gln Gln 
                85                  90                  95      


Ala Leu Val Gln Lys Arg His Tyr Leu Phe Asp Val Gln Arg Asn Asn 
            100                 105                 110         


Ile Ala Met Ala Leu Glu Val Thr Tyr Arg Glu Arg Leu Tyr Arg Val 
        115                 120                 125             


Tyr Lys Glu Val Lys Asn Arg Leu Asp Tyr His Ile Ser Val Gln Asn 
    130                 135                 140                 


Met Met Arg Arg Lys Glu Gln Glu His Met Ile Asn Trp Val Glu Lys 
145                 150                 155                 160 


His Val Val Gln Ser Ile Ser Thr Gln Gln Glu Lys Glu Thr Ile Ala 
                165                 170                 175     


Lys Cys Ile Ala Asp Leu Lys Leu Leu Ala Lys Lys Ala Gln Ala Gln 
            180                 185                 190         


Pro Val Met 
        195 


<210>  1237
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  1237

Ala Gln Ala Leu Trp Arg Met Pro Trp Leu Pro Val Phe Leu Ser Leu 
1               5                   10                  15      


Ala Ala Ala Ala Ala Ala Ala Ala Ala Glu Gln Gln Val Pro Leu Val 
            20                  25                  30          


Leu Trp Ser Ser Asp Arg Asp Leu Trp Ala Pro Ala Ala Asp Thr His 
        35                  40                  45              


Glu Gly His Ile Thr Ser Asp Leu Gln Leu Ser Thr Tyr Leu Asp Pro 
    50                  55                  60                  


Ala Leu Glu Leu Gly Pro Arg Asn Val Leu Leu Phe Leu Gln Asp Lys 
65                  70                  75                  80  


Leu Ser Ile Glu Asp Phe Thr Ala Tyr Gly Gly Val Phe Gly Asn Lys 
                85                  90                  95      


Gln Asp Ser Ala Phe Ser Asn Leu Glu His Thr Gln Val Arg Arg Cys 
            100                 105                 110         


Pro Ile His Ser Gly Pro His Ser Gly Pro Pro Phe Gln Gly Gly Pro 
        115                 120                 125             


<210>  1238
<211>  281
<212>  PRT
<213>  Homo Sapiens

<400>  1238

Met Ala Pro Arg Glu Val Leu Thr Gly Asn Asp Glu Val Ile Gly Gln 
1               5                   10                  15      


Val Leu Ser Thr Leu Lys Ser Glu Asp Val Pro Tyr Thr Ala Ala Leu 
            20                  25                  30          


Thr Ala Val Arg Pro Ser Arg Val Ala Arg Asp Val Ala Val Val Ala 
        35                  40                  45              


Gly Gly Leu Gly Arg Gln Leu Leu Gln Lys Gln Pro Val Ser Pro Val 
    50                  55                  60                  


Ile His Pro Pro Val Ser Tyr Asn Asp Thr Ala Pro Arg Ile Leu Phe 
65                  70                  75                  80  


Trp Ala Gln Asn Phe Ser Val Ala Tyr Lys Asp Gln Trp Glu Asp Leu 
                85                  90                  95      


Thr Pro Leu Thr Phe Gly Val Gln Glu Leu Asn Leu Thr Gly Ser Phe 
            100                 105                 110         


Trp Asn Asp Ser Phe Ala Arg Leu Ser Leu Thr Tyr Glu Arg Leu Phe 
        115                 120                 125             


Gly Thr Thr Val Thr Phe Lys Phe Ile Leu Ala Asn Arg Leu Tyr Pro 
    130                 135                 140                 


Val Ser Ala Arg His Trp Phe Thr Met Glu Arg Leu Glu Val His Ser 
145                 150                 155                 160 


Asn Gly Ser Val Ala Tyr Phe Asn Ala Ser Gln Val Thr Gly Pro Ser 
                165                 170                 175     


Ile Tyr Ser Phe His Cys Glu Tyr Val Ser Ser Leu Ser Lys Lys Gly 
            180                 185                 190         


Ser Leu Leu Val Ala Arg Thr Gln Pro Ser Pro Trp Gln Met Met Leu 
        195                 200                 205             


Gln Asp Phe Gln Ile Gln Ala Phe Asn Val Met Gly Glu Gln Phe Ser 
    210                 215                 220                 


Tyr Ala Ser Asp Cys Ala Ser Phe Phe Ser Pro Gly Ile Trp Met Gly 
225                 230                 235                 240 


Leu Leu Thr Ser Leu Phe Met Leu Phe Ile Phe Thr Tyr Gly Leu His 
                245                 250                 255     


Met Ile Leu Ser Leu Lys Thr Met Asp Arg Phe Asp Asp His Lys Gly 
            260                 265                 270         


Pro Thr Ile Ser Leu Thr Gln Ile Val 
        275                 280     


<210>  1239
<211>  273
<212>  PRT
<213>  Homo Sapiens

<400>  1239

Met Met Ala Ala Met Ala Thr Ala Arg Val Arg Met Gly Pro Arg Cys 
1               5                   10                  15      


Ala Gln Ala Leu Trp Arg Met Pro Trp Leu Pro Val Phe Leu Ser Leu 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Ala Ala Glu Gln Gln Val Pro Leu Val 
        35                  40                  45              


Leu Trp Ser Ser Asp Arg Asp Leu Trp Ala Pro Ala Ala Asp Thr His 
    50                  55                  60                  


Glu Gly His Ile Thr Ser Asp Leu Gln Leu Ser Thr Tyr Leu Asp Pro 
65                  70                  75                  80  


Ala Leu Glu Leu Gly Pro Arg Asn Val Leu Leu Phe Leu Gln Asp Lys 
                85                  90                  95      


Leu Ser Ile Glu Asp Phe Thr Ala Tyr Gly Gly Val Phe Gly Asn Lys 
            100                 105                 110         


Gln Asp Ser Ala Phe Ser Asn Leu Glu Asn Ala Leu Asp Leu Ala Pro 
        115                 120                 125             


Ser Ser Leu Val Leu Pro Ala Val Asp Trp Tyr Ala Val Ser Thr Leu 
    130                 135                 140                 


Thr Thr Tyr Leu Gln Glu Lys Leu Gly Ala Ser Pro Leu His Val Ala 
145                 150                 155                 160 


Arg Asp Val Ala Val Val Ala Gly Gly Leu Gly Arg Gln Leu Leu Gln 
                165                 170                 175     


Lys Gln Pro Val Ser Pro Val Ile His Pro Pro Val Ser Tyr Asn Asp 
            180                 185                 190         


Thr Ala Pro Arg Ile Leu Phe Trp Ala Gln Asn Phe Ser Val Ala Tyr 
        195                 200                 205             


Lys Asp Gln Trp Glu Asp Leu Thr Pro Leu Thr Phe Gly Val Gln Glu 
    210                 215                 220                 


Leu Asn Leu Thr Gly Ser Phe Trp Asn Asp Ser Phe Ala Arg Phe Ile 
225                 230                 235                 240 


Leu Ala Asn Arg Leu Tyr Pro Val Ser Ala Arg His Trp Phe Thr Met 
                245                 250                 255     


Glu Arg Leu Glu Val His Ser Asn Gly Ser Val Ala Tyr Phe Asn Ala 
            260                 265                 270         


Ser 
    


<210>  1240
<211>  230
<212>  PRT
<213>  Homo Sapiens

<400>  1240

Met Met Ala Ala Met Ala Thr Ala Arg Val Arg Met Gly Pro Arg Cys 
1               5                   10                  15      


Ala Gln Ala Leu Trp Arg Met Pro Trp Leu Pro Val Phe Leu Ser Leu 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Ala Ala Glu Gln Gln Val Pro Leu Val 
        35                  40                  45              


Leu Trp Ser Ser Asp Arg Asp Leu Trp Ala Pro Ala Ala Asp Thr His 
    50                  55                  60                  


Glu Gly His Ile Thr Ser Asp Leu Gln Leu Ser Thr Tyr Leu Asp Pro 
65                  70                  75                  80  


Ala Leu Glu Leu Gly Pro Arg Asn Val Leu Leu Phe Leu Gln Asp Lys 
                85                  90                  95      


Leu Ser Ile Glu Asp Phe Thr Ala Tyr Gly Gly Val Phe Gly Asn Lys 
            100                 105                 110         


Gln Asp Ser Ala Phe Ser Asn Leu Glu Asn Ala Leu Asp Leu Ala Pro 
        115                 120                 125             


Ser Ser Leu Val Leu Pro Ala Val Asp Trp Tyr Ala Val Ser Thr Leu 
    130                 135                 140                 


Thr Thr Tyr Leu Gln Glu Lys Leu Gly Ala Ser Pro Leu His Val Asp 
145                 150                 155                 160 


Leu Ala Thr Leu Arg Glu Leu Lys Leu Asn Ala Ser Leu Pro Ala Leu 
                165                 170                 175     


Leu Leu Ile Arg Leu Pro Tyr Thr Ala Ser Ser Gly Leu Met Ala Pro 
            180                 185                 190         


Arg Glu Val Leu Thr Asp Glu Val Ile Gly Gln Val Leu Ser Thr Leu 
        195                 200                 205             


Lys Ser Glu Asp Val Pro Tyr Thr Ala Ala Leu Thr Ala Val Arg Pro 
    210                 215                 220                 


Ser Arg Val Ala Arg Asp 
225                 230 


<210>  1241
<211>  470
<212>  PRT
<213>  Homo Sapiens

<400>  1241

Met Met Ala Ala Met Ala Thr Ala Arg Val Arg Met Gly Pro Arg Cys 
1               5                   10                  15      


Ala Gln Ala Leu Trp Arg Met Pro Trp Leu Pro Val Phe Leu Ser Leu 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Ala Ala Glu Gln Gln Val Pro Leu Val 
        35                  40                  45              


Leu Trp Ser Ser Asp Arg Asp Leu Trp Ala Pro Ala Ala Asp Thr His 
    50                  55                  60                  


Glu Gly His Ile Thr Ser Asp Leu Gln Leu Ser Thr Tyr Leu Asp Pro 
65                  70                  75                  80  


Ala Leu Glu Leu Gly Pro Arg Asn Val Leu Leu Phe Leu Gln Asp Lys 
                85                  90                  95      


Leu Ser Ile Glu Asp Phe Thr Ala Tyr Gly Gly Val Phe Gly Asn Lys 
            100                 105                 110         


Gln Asp Ser Ala Phe Ser Asn Leu Glu Asn Ala Leu Asp Leu Ala Pro 
        115                 120                 125             


Ser Ser Leu Val Leu Pro Ala Val Asp Trp Tyr Ala Val Ser Thr Leu 
    130                 135                 140                 


Thr Thr Tyr Leu Gln Glu Lys Leu Gly Ala Ser Pro Leu His Val Asp 
145                 150                 155                 160 


Leu Ala Thr Leu Arg Glu Leu Lys Leu Asn Ala Ser Leu Pro Ala Leu 
                165                 170                 175     


Leu Leu Ile Arg Leu Pro Tyr Thr Ala Ser Ser Gly Leu Met Ala Pro 
            180                 185                 190         


Arg Glu Val Leu Thr Gly Asn Asp Glu Val Ile Gly Gln Val Leu Ser 
        195                 200                 205             


Thr Leu Lys Ser Glu Asp Val Pro Tyr Thr Ala Ala Leu Thr Ala Val 
    210                 215                 220                 


Arg Pro Ser Arg Val Ala Arg Asp Val Ala Val Val Ala Gly Gly Leu 
225                 230                 235                 240 


Gly Arg Gln Leu Leu Gln Lys Gln Pro Val Ser Pro Val Ile His Pro 
                245                 250                 255     


Pro Val Ser Tyr Asn Asp Thr Ala Pro Arg Ile Leu Phe Trp Ala Gln 
            260                 265                 270         


Asn Phe Ser Val Ala Tyr Lys Asp Gln Trp Glu Asp Leu Thr Pro Leu 
        275                 280                 285             


Thr Phe Gly Val Gln Glu Leu Asn Leu Thr Gly Ser Phe Trp Asn Asp 
    290                 295                 300                 


Ser Phe Ala Arg Leu Ser Leu Thr Tyr Glu Arg Leu Phe Gly Thr Thr 
305                 310                 315                 320 


Val Thr Phe Lys Phe Ile Leu Ala Asn Arg Leu Tyr Pro Val Ser Ala 
                325                 330                 335     


Arg His Trp Phe Thr Met Glu Arg Leu Glu Val His Ser Asn Gly Ser 
            340                 345                 350         


Val Ala Tyr Phe Asn Ala Ser Gln Val Thr Gly Pro Ser Ile Tyr Ser 
        355                 360                 365             


Phe His Cys Glu Tyr Val Ser Ser Leu Ser Lys Lys Gly Ser Leu Leu 
    370                 375                 380                 


Val Ala Arg Thr Gln Pro Ser Pro Trp Gln Met Met Leu Gln Asp Phe 
385                 390                 395                 400 


Gln Ile Gln Ala Phe Asn Val Met Gly Glu Gln Phe Ser Tyr Ala Ser 
                405                 410                 415     


Asp Cys Ala Ser Phe Phe Ser Pro Gly Ile Trp Met Gly Leu Leu Thr 
            420                 425                 430         


Ser Leu Phe Met Leu Phe Ile Phe Thr Tyr Gly Leu His Met Ile Leu 
        435                 440                 445             


Ser Leu Lys Thr Met Asp Arg Phe Asp Asp His Lys Gly Pro Thr Ile 
    450                 455                 460                 


Ser Leu Thr Gln Ile Val 
465                 470 


<210>  1242
<211>  134
<212>  PRT
<213>  Homo Sapiens

<400>  1242

Met Met Ala Ala Met Ala Thr Ala Arg Val Arg Met Gly Pro Arg Cys 
1               5                   10                  15      


Ala Gln Ala Leu Trp Arg Met Pro Trp Leu Pro Val Phe Leu Ser Leu 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Ala Ala Glu Gln Gln Val Pro Leu Val 
        35                  40                  45              


Leu Trp Ser Ser Asp Arg Asp Leu Trp Ala Pro Ala Ala Asp Thr His 
    50                  55                  60                  


Glu Gly His Ile Thr Ser Asp Leu Gln Leu Ser Thr Tyr Leu Asp Pro 
65                  70                  75                  80  


Ala Leu Glu Leu Gly Pro Arg Asn Val Leu Leu Phe Leu Gln Asp Lys 
                85                  90                  95      


Val Arg Pro Pro Gln Pro Thr Leu Pro Arg Ser Ser Gly Gly Ser Gln 
            100                 105                 110         


Ala Pro Ser Pro His Asp Thr Asp Ala His Ser Pro Arg Glu Ala Ser 
        115                 120                 125             


Val Thr Leu Ser Gln Leu 
    130                 


<210>  1243
<211>  134
<212>  PRT
<213>  Homo Sapiens

<400>  1243

Met Met Ala Ala Met Ala Thr Ala Arg Val Arg Met Gly Pro Arg Cys 
1               5                   10                  15      


Ala Gln Ala Leu Trp Arg Met Pro Trp Leu Pro Val Phe Leu Ser Leu 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Ala Ala Glu Gln Gln Val Pro Leu Val 
        35                  40                  45              


Leu Trp Ser Ser Asp Arg Asp Leu Trp Ala Pro Ala Ala Asp Thr His 
    50                  55                  60                  


Glu Gly His Ile Thr Ser Asp Leu Gln Leu Ser Thr Tyr Leu Asp Pro 
65                  70                  75                  80  


Ala Leu Glu Leu Gly Pro Arg Asn Val Leu Leu Phe Leu Gln Asp Lys 
                85                  90                  95      


Val Arg Pro Pro Gln Pro Thr Leu Pro Arg Ser Ser Gly Gly Ser Gln 
            100                 105                 110         


Ala Pro Ser Pro His Asp Thr Asp Ala His Ser Pro Arg Glu Ala Ser 
        115                 120                 125             


Val Thr Leu Ser Gln Leu 
    130                 


<210>  1244
<211>  133
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1244

Xaa Ala Ala Met Ala Thr Ala Arg Val Arg Met Gly Pro Arg Cys Ala 
1               5                   10                  15      


Gln Ala Leu Trp Arg Met Pro Trp Leu Pro Val Phe Leu Ser Leu Ala 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Ala Glu Gln Gln Val Pro Leu Val Leu 
        35                  40                  45              


Trp Ser Ser Asp Arg Asp Leu Trp Ala Pro Ala Ala Asp Thr His Glu 
    50                  55                  60                  


Gly His Ile Thr Ser Asp Leu Gln Leu Ser Thr Tyr Leu Asp Pro Ala 
65                  70                  75                  80  


Leu Glu Leu Gly Pro Arg Asn Val Leu Leu Phe Leu Gln Asp Lys Val 
                85                  90                  95      


Arg Pro Pro Gln Pro Thr Leu Pro Arg Ser Ser Gly Gly Ser Gln Ala 
            100                 105                 110         


Pro Ser Pro His Asp Thr Asp Ala His Ser Pro Arg Glu Ala Ser Val 
        115                 120                 125             


Thr Leu Ser Gln Leu 
    130             


<210>  1245
<211>  186
<212>  PRT
<213>  Homo Sapiens

<400>  1245

Phe His Arg Pro Arg Ala Thr Val Met Val Met Val Lys Gly Val Asn 
1               5                   10                  15      


Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser Tyr Pro Leu Glu Asn 
            20                  25                  30          


Leu Ser Arg His Lys His Leu Ala Lys Asp His Ser Pro Asp Leu Tyr 
        35                  40                  45              


Ser Leu Glu Leu Ala Gly Leu Asp Glu Ile Gly Lys Arg Tyr Gly Glu 
    50                  55                  60                  


Asp Ser Glu Gln Phe Arg Asp Ala Ser Lys Ile Leu Val Asp Ala Leu 
65                  70                  75                  80  


Gln Lys Phe Ala Asp Asp Met Tyr Ser Leu Tyr Gly Gly Asn Ala Val 
                85                  90                  95      


Val Glu Leu Val Thr Val Lys Ser Phe Asp Thr Ser Leu Ile Arg Lys 
            100                 105                 110         


Thr Arg Thr Ile Leu Glu Ala Lys Gln Ala Lys Asn Pro Ala Ser Pro 
        115                 120                 125             


Tyr Asn Leu Ala Tyr Lys Tyr Asn Phe Glu Tyr Ser Val Val Phe Asn 
    130                 135                 140                 


Met Val Leu Trp Ile Met Ile Ala Leu Ala Leu Ala Val Ile Ile Thr 
145                 150                 155                 160 


Ser Tyr Asn Ile Trp Asn Met Asp Pro Gly Tyr Asp Ser Ile Ile Tyr 
                165                 170                 175     


Arg Met Thr Asn Gln Lys Ile Arg Met Asp 
            180                 185     


<210>  1246
<211>  186
<212>  PRT
<213>  Homo Sapiens

<400>  1246

Met Ala Val Phe Val Val Leu Leu Ala Leu Val Ala Gly Val Leu Gly 
1               5                   10                  15      


Asn Glu Phe Ser Ile Leu Lys Ser Pro Gly Ser Val Val Phe Arg Asn 
            20                  25                  30          


Gly Asn Trp Pro Ile Pro Gly Glu Arg Ile Pro Asp Val Ala Ala Leu 
        35                  40                  45              


Ser Met Gly Phe Ser Val Lys Glu Asp Leu Ser Trp Pro Gly Leu Ala 
    50                  55                  60                  


Val Gly Asn Leu Phe His Arg Pro Arg Ala Thr Val Met Val Met Val 
65                  70                  75                  80  


Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser Tyr 
                85                  90                  95      


Pro Leu Glu Asn Ala Val Pro Phe Ser Leu Asp Ser Val Ala Asn Ser 
            100                 105                 110         


Ile His Ser Leu Phe Ser Glu Glu Thr Pro Val Val Leu Gln Leu Ala 
        115                 120                 125             


Pro Ser Glu Glu Arg Val Tyr Met Val Gly Lys Ala Asn Ser Val Phe 
    130                 135                 140                 


Glu Asp Leu Ser Val Thr Leu Arg Gln Leu Arg Asn Arg Leu Phe Gln 
145                 150                 155                 160 


Glu Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser Leu Ser Arg Asn 
                165                 170                 175     


Asn Glu Asn Ala Leu Phe Phe Trp Ala Leu 
            180                 185     


<210>  1247
<211>  209
<212>  PRT
<213>  Homo Sapiens

<400>  1247

Met Ala Val Phe Val Val Leu Leu Ala Leu Val Ala Gly Val Leu Gly 
1               5                   10                  15      


Asn Glu Phe Ser Ile Leu Lys Ser Pro Gly Ser Val Val Phe Arg Asn 
            20                  25                  30          


Gly Asn Trp Pro Ile Pro Gly Glu Arg Ile Pro Asp Val Ala Ala Leu 
        35                  40                  45              


Ser Met Gly Phe Ser Val Lys Glu Asp Leu Ser Trp Pro Gly Leu Ala 
    50                  55                  60                  


Val Gly Asn Leu Phe His Arg Pro Arg Ala Thr Val Met Val Met Val 
65                  70                  75                  80  


Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser Tyr 
                85                  90                  95      


Pro Leu Glu Asn Ala Val Pro Phe Ser Leu Asp Ser Val Ala Asn Ser 
            100                 105                 110         


Ile His Ser Leu Phe Ser Glu Glu Thr Pro Val Val Leu Gln Leu Ala 
        115                 120                 125             


Pro Ser Glu Glu Arg Val Tyr Met Val Gly Lys Ala Asn Ser Val Phe 
    130                 135                 140                 


Glu Asp Leu Ser Val Thr Leu Arg Gln Leu Arg Asn Arg Leu Phe Gln 
145                 150                 155                 160 


Glu Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser Leu Ser Arg Asn 
                165                 170                 175     


Asn Glu Val Asp Leu Leu Phe Leu Ser Glu Leu Gln Val Leu His Asp 
            180                 185                 190         


Ile Ser Ser Leu Gly Glu Thr Thr Tyr Leu Pro Arg Thr Gln Ala Trp 
        195                 200                 205             


Ala 
    


<210>  1248
<211>  345
<212>  PRT
<213>  Homo Sapiens

<400>  1248

Met Ala Val Phe Val Val Leu Leu Ala Leu Val Ala Gly Val Leu Gly 
1               5                   10                  15      


Asn Glu Phe Ser Ile Leu Lys Ser Pro Gly Ser Val Val Phe Arg Asn 
            20                  25                  30          


Gly Asn Trp Pro Ile Pro Gly Glu Arg Ile Pro Asp Val Ala Ala Leu 
        35                  40                  45              


Ser Met Gly Phe Ser Val Lys Glu Asp Leu Ser Trp Pro Gly Leu Ala 
    50                  55                  60                  


Val Gly Asn Leu Phe His Arg Pro Arg Ala Thr Val Met Val Met Val 
65                  70                  75                  80  


Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser Tyr 
                85                  90                  95      


Pro Leu Glu Asn Ala Val Pro Phe Ser Leu Asp Ser Val Ala Asn Ser 
            100                 105                 110         


Ile His Ser Leu Phe Ser Glu Glu Thr Pro Val Val Leu Gln Leu Ala 
        115                 120                 125             


Pro Ser Glu Glu Arg Val Tyr Met Val Gly Lys Ala Asn Ser Val Phe 
    130                 135                 140                 


Glu Asp Leu Ser Val Thr Leu Arg Gln Leu Arg Asn Arg Leu Phe Gln 
145                 150                 155                 160 


Glu Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser Leu Ser Arg Asn 
                165                 170                 175     


Asn Glu Val Asp Leu Leu Phe Leu Ser Glu Leu Gln Val Leu His Asp 
            180                 185                 190         


Ile Ser Ser Leu His Leu Ala Lys Asp His Ser Pro Asp Leu Tyr Ser 
        195                 200                 205             


Leu Glu Leu Ala Gly Leu Asp Glu Ile Gly Lys Arg Tyr Gly Glu Asp 
    210                 215                 220                 


Ser Glu Gln Phe Arg Asp Ala Ser Lys Ile Leu Val Asp Ala Leu Gln 
225                 230                 235                 240 


Lys Phe Ala Asp Asp Met Tyr Ser Leu Tyr Gly Gly Asn Ala Val Val 
                245                 250                 255     


Glu Leu Val Thr Val Lys Ser Phe Asp Thr Ser Leu Ile Arg Lys Thr 
            260                 265                 270         


Arg Thr Ile Leu Glu Ala Lys Gln Ala Lys Asn Pro Ala Ser Pro Tyr 
        275                 280                 285             


Asn Leu Ala Tyr Lys Tyr Asn Phe Glu Tyr Ser Val Val Phe Asn Met 
    290                 295                 300                 


Val Leu Trp Ile Met Ile Ala Leu Ala Leu Ala Val Ile Ile Thr Ser 
305                 310                 315                 320 


Tyr Asn Ile Trp Asn Met Asp Pro Gly Tyr Asp Ser Ile Ile Tyr Arg 
                325                 330                 335     


Met Thr Asn Gln Lys Ile Arg Met Asp 
            340                 345 


<210>  1249
<211>  331
<212>  PRT
<213>  Homo Sapiens

<400>  1249

Met Ala Val Phe Val Val Leu Leu Ala Leu Val Ala Gly Val Leu Gly 
1               5                   10                  15      


Asn Glu Phe Ser Ile Leu Lys Ser Pro Gly Ser Val Val Phe Arg Asn 
            20                  25                  30          


Gly Asn Trp Pro Ile Pro Gly Glu Arg Ile Pro Asp Val Ala Ala Leu 
        35                  40                  45              


Ser Met Gly Phe Ser Val Lys Glu Asp Leu Ser Trp Pro Gly Leu Ala 
    50                  55                  60                  


Val Gly Asn Leu Phe His Arg Pro Arg Ala Thr Val Met Val Met Val 
65                  70                  75                  80  


Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser Tyr 
                85                  90                  95      


Pro Leu Glu Asn Ala Val Pro Phe Ser Leu Asp Ser Val Ala Asn Ser 
            100                 105                 110         


Ile His Ser Leu Phe Ser Glu Glu Thr Pro Val Val Leu Gln Leu Ala 
        115                 120                 125             


Pro Ser Glu Glu Arg Val Tyr Met Val Gly Lys Ala Asn Ser Val Phe 
    130                 135                 140                 


Glu Asp Leu Ser Val Thr Leu Arg Gln Leu Arg Asn Arg Leu Phe Gln 
145                 150                 155                 160 


Glu Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser Leu Ser Arg Asn 
                165                 170                 175     


Asn Glu Val Asp Leu Leu Phe Leu Ser Glu Leu Gln Val Leu His Asp 
            180                 185                 190         


Ile Ser Ser Leu Leu Ala Gly Leu Asp Glu Ile Gly Lys Arg Tyr Gly 
        195                 200                 205             


Glu Asp Ser Glu Gln Phe Arg Asp Ala Ser Lys Ile Leu Val Asp Ala 
    210                 215                 220                 


Leu Gln Lys Phe Ala Asp Asp Met Tyr Ser Leu Tyr Gly Gly Asn Ala 
225                 230                 235                 240 


Val Val Glu Leu Val Thr Val Lys Ser Phe Asp Thr Ser Leu Ile Arg 
                245                 250                 255     


Lys Thr Arg Thr Ile Leu Glu Ala Lys Gln Ala Lys Asn Pro Ala Ser 
            260                 265                 270         


Pro Tyr Asn Leu Ala Tyr Lys Tyr Asn Phe Glu Tyr Ser Val Val Phe 
        275                 280                 285             


Asn Met Val Leu Trp Ile Met Ile Ala Leu Ala Leu Ala Val Ile Ile 
    290                 295                 300                 


Thr Ser Tyr Asn Ile Trp Asn Met Asp Pro Gly Tyr Asp Ser Ile Ile 
305                 310                 315                 320 


Tyr Arg Met Thr Asn Gln Lys Ile Arg Met Asp 
                325                 330     


<210>  1250
<211>  349
<212>  PRT
<213>  Homo Sapiens

<400>  1250

Met Ala Val Phe Val Val Leu Leu Ala Leu Val Ala Gly Val Leu Gly 
1               5                   10                  15      


Asn Glu Phe Ser Ile Leu Lys Ser Pro Gly Ser Val Val Phe Arg Asn 
            20                  25                  30          


Gly Asn Trp Pro Ile Pro Gly Glu Arg Ile Pro Asp Val Ala Ala Leu 
        35                  40                  45              


Ser Met Gly Phe Ser Val Lys Glu Asp Leu Ser Trp Pro Gly Leu Ala 
    50                  55                  60                  


Val Gly Asn Leu Phe His Arg Pro Arg Ala Thr Val Met Val Met Val 
65                  70                  75                  80  


Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser Tyr 
                85                  90                  95      


Pro Leu Glu Asn Ala Val Pro Phe Ser Leu Asp Ser Val Ala Asn Ser 
            100                 105                 110         


Ile His Ser Leu Phe Ser Glu Glu Thr Pro Val Val Leu Gln Leu Ala 
        115                 120                 125             


Pro Ser Glu Glu Arg Val Tyr Met Val Gly Lys Ala Asn Ser Val Phe 
    130                 135                 140                 


Glu Asp Leu Ser Val Thr Leu Arg Gln Leu Arg Asn Arg Leu Phe Gln 
145                 150                 155                 160 


Glu Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser Leu Ser Arg Asn 
                165                 170                 175     


Asn Glu Val Asp Leu Leu Phe Leu Ser Glu Leu Gln Val Leu His Asp 
            180                 185                 190         


Ile Ser Ser Leu Leu Ser Arg His Lys His Leu Ala Lys Asp His Ser 
        195                 200                 205             


Pro Asp Leu Tyr Ser Leu Glu Leu Ala Gly Leu Asp Glu Ile Gly Lys 
    210                 215                 220                 


Arg Tyr Gly Glu Asp Ser Glu Gln Phe Arg Asp Ala Ser Lys Ile Leu 
225                 230                 235                 240 


Val Asp Ala Leu Gln Lys Phe Ala Asp Asp Met Tyr Ser Leu Tyr Gly 
                245                 250                 255     


Gly Asn Ala Val Val Glu Leu Val Thr Val Lys Ser Phe Asp Thr Ser 
            260                 265                 270         


Leu Ile Arg Lys Thr Arg Thr Ile Leu Glu Ala Lys Gln Ala Asn Pro 
        275                 280                 285             


Ala Ser Pro Tyr Asn Leu Ala Tyr Lys Tyr Asn Phe Glu Tyr Ser Val 
    290                 295                 300                 


Val Phe Asn Met Val Leu Trp Ile Met Ile Ala Leu Ala Leu Ala Val 
305                 310                 315                 320 


Ile Ile Thr Ser Tyr Asn Ile Trp Asn Met Asp Pro Gly Tyr Asp Ser 
                325                 330                 335     


Ile Ile Tyr Arg Met Thr Asn Gln Lys Ile Arg Met Asp 
            340                 345                 


<210>  1251
<211>  350
<212>  PRT
<213>  Homo Sapiens

<400>  1251

Met Ala Val Phe Val Val Leu Leu Ala Leu Val Ala Gly Val Leu Gly 
1               5                   10                  15      


Asn Glu Phe Ser Ile Leu Lys Ser Pro Gly Ser Val Val Phe Arg Asn 
            20                  25                  30          


Gly Asn Trp Pro Ile Pro Gly Glu Arg Ile Pro Asp Val Ala Ala Leu 
        35                  40                  45              


Ser Met Gly Phe Ser Val Lys Glu Asp Leu Ser Trp Pro Gly Leu Ala 
    50                  55                  60                  


Val Gly Asn Leu Phe His Arg Pro Arg Ala Thr Val Met Val Met Val 
65                  70                  75                  80  


Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser Tyr 
                85                  90                  95      


Pro Leu Glu Asn Ala Val Pro Phe Ser Leu Asp Ser Val Ala Asn Ser 
            100                 105                 110         


Ile His Ser Leu Phe Ser Glu Glu Thr Pro Val Val Leu Gln Leu Ala 
        115                 120                 125             


Pro Ser Glu Glu Arg Val Tyr Met Val Gly Lys Ala Asn Ser Val Phe 
    130                 135                 140                 


Glu Asp Leu Ser Val Thr Leu Arg Gln Leu Arg Asn Arg Leu Phe Gln 
145                 150                 155                 160 


Glu Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser Leu Ser Arg Asn 
                165                 170                 175     


Asn Glu Val Asp Leu Leu Phe Leu Ser Glu Leu Gln Val Leu His Asp 
            180                 185                 190         


Ile Ser Ser Leu Leu Ser Arg His Lys His Leu Ala Lys Asp His Ser 
        195                 200                 205             


Pro Asp Leu Tyr Ser Leu Glu Leu Ala Gly Leu Asp Glu Ile Gly Lys 
    210                 215                 220                 


Arg Tyr Gly Glu Asp Ser Glu Gln Phe Arg Asp Ala Ser Lys Ile Leu 
225                 230                 235                 240 


Val Asp Ala Leu Gln Lys Phe Ala Asp Asp Met Tyr Ser Leu Tyr Gly 
                245                 250                 255     


Gly Asn Ala Val Val Glu Leu Val Thr Val Lys Ser Phe Asp Thr Ser 
            260                 265                 270         


Leu Ile Arg Lys Thr Arg Thr Ile Leu Glu Ala Lys Gln Ala Lys Asn 
        275                 280                 285             


Pro Ala Ser Pro Tyr Asn Leu Ala Tyr Lys Tyr Asn Phe Glu Tyr Ser 
    290                 295                 300                 


Val Val Phe Asn Met Val Leu Trp Ile Met Ile Ala Leu Ala Leu Ala 
305                 310                 315                 320 


Val Ile Ile Thr Ser Tyr Asn Ile Trp Asn Met Asp Pro Gly Tyr Asp 
                325                 330                 335     


Ser Ile Ile Tyr Arg Met Thr Asn Gln Lys Ile Arg Met Asp 
            340                 345                 350 


<210>  1252
<211>  258
<212>  PRT
<213>  Homo Sapiens

<400>  1252

Met Ala Val Phe Val Val Leu Leu Ala Leu Val Ala Gly Val Leu Gly 
1               5                   10                  15      


Asn Glu Phe Ser Ile Leu Lys Ser Pro Gly Ser Val Val Phe Arg Asn 
            20                  25                  30          


Gly Asn Trp Pro Ile Pro Gly Glu Arg Ile Pro Asp Val Ala Ala Leu 
        35                  40                  45              


Ser Met Gly Phe Ser Val Lys Glu Asp Leu Ser Trp Pro Gly Leu Ala 
    50                  55                  60                  


Val Gly Asn Leu Phe His Arg Pro Arg Ala Thr Val Met Val Met Val 
65                  70                  75                  80  


Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser Tyr 
                85                  90                  95      


Pro Leu Glu Asn Ala Val Pro Phe Ser Leu Asp Ser Val Ala Asn Ser 
            100                 105                 110         


Ile His Ser Leu Phe Ser Glu Glu Thr Pro Val Val Leu Gln Leu Ala 
        115                 120                 125             


Pro Ser Glu Glu Arg Val Tyr Met Val Gly Lys Ala Asn Ser Val Phe 
    130                 135                 140                 


Glu Asp Leu Ser Val Thr Leu Arg Gln Leu Arg Asn Arg Leu Phe Gln 
145                 150                 155                 160 


Glu Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser Leu Ser Arg Asn 
                165                 170                 175     


Asn Glu Val Asp Leu Leu Phe Leu Ser Glu Leu Gln Val Leu His Asp 
            180                 185                 190         


Ile Ser Ser Leu Leu Ser Arg His Lys His Leu Ala Lys Asp His Ser 
        195                 200                 205             


Pro Asp Leu Tyr Ser Leu Glu Leu Ala Gly Leu Asp Glu Ile Gly Lys 
    210                 215                 220                 


Arg Tyr Gly Glu Asp Ser Glu Gln Phe Arg Asp Ala Ser Lys Ile Leu 
225                 230                 235                 240 


Val Asp Ala Leu Gln Lys Met Thr Cys Thr Val Phe Met Val Gly Met 
                245                 250                 255     


Gln Trp 
        


<210>  1253
<211>  262
<212>  PRT
<213>  Homo Sapiens

<400>  1253

Met Ala Val Phe Val Val Leu Leu Ala Leu Val Ala Gly Val Leu Gly 
1               5                   10                  15      


Asn Glu Phe Ser Ile Leu Lys Ser Pro Gly Ser Val Val Phe Arg Asn 
            20                  25                  30          


Gly Asn Trp Pro Ile Pro Gly Glu Arg Ile Pro Asp Val Ala Ala Leu 
        35                  40                  45              


Ser Met Gly Phe Ser Val Lys Glu Asp Leu Ser Trp Pro Gly Leu Ala 
    50                  55                  60                  


Val Gly Asn Leu Phe His Arg Pro Arg Ala Thr Val Met Val Met Val 
65                  70                  75                  80  


Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser Tyr 
                85                  90                  95      


Pro Leu Glu Asn Ala Val Pro Phe Ser Leu Asp Ser Val Ala Asn Ser 
            100                 105                 110         


Ile His Ser Leu Phe Ser Glu Glu Thr Pro Val Val Leu Gln Leu Ala 
        115                 120                 125             


Pro Ser Glu Glu Arg Val Tyr Met Val Gly Lys Ala Asn Ser Val Phe 
    130                 135                 140                 


Glu Asp Leu Ser Val Thr Leu Arg Gln Leu Arg Asn Arg Leu Phe Gln 
145                 150                 155                 160 


Glu Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser Leu Ser Arg Asn 
                165                 170                 175     


Asn Glu Val Asp Leu Leu Phe Leu Ser Glu Leu Gln Val Leu His Asp 
            180                 185                 190         


Ile Ser Ser Leu Leu Ser Arg His Lys His Leu Ala Lys Asp His Ser 
        195                 200                 205             


Pro Asp Leu Tyr Ser Leu Glu Leu Ala Gly Leu Asp Glu Ile Gly Lys 
    210                 215                 220                 


Arg Tyr Gly Glu Asp Ser Glu Gln Phe Arg Asp Ala Ser Lys Ile Leu 
225                 230                 235                 240 


Val Asp Ala Leu Gln Lys Ser Leu Trp Trp Glu Cys Ser Gly Arg Val 
                245                 250                 255     


Ser His Cys Gln Val Ile 
            260         


<210>  1254
<211>  143
<212>  PRT
<213>  Homo Sapiens

<400>  1254

Met Ala Val Phe Val Val Leu Leu Ala Leu Val Ala Gly Val Leu Gly 
1               5                   10                  15      


Asn Glu Phe Ser Ile Leu Lys Ser Pro Gly Ser Val Val Phe Arg Asn 
            20                  25                  30          


Gly Asn Trp Pro Ile Pro Gly Glu Arg Ile Pro Asp Val Ala Ala Leu 
        35                  40                  45              


Ser Met Gly Phe Ser Val Lys Glu Asp Leu Ser Trp Pro Gly Leu Ala 
    50                  55                  60                  


Val Gly Asn Leu Phe His Arg Pro Arg Ala Thr Val Met Val Met Val 
65                  70                  75                  80  


Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser Tyr 
                85                  90                  95      


Pro Leu Glu Asn Ala Val Pro Phe Ser Leu Asp Ser Val Ala Asn Ser 
            100                 105                 110         


Ile His Ser Leu Phe Ser Glu Glu Thr Pro Val Val Leu Gln Leu Ala 
        115                 120                 125             


Pro Ser Glu Glu Ser Val Tyr Gly Arg Glu Gly Lys Leu Ser Val 
    130                 135                 140             


<210>  1255
<211>  318
<212>  PRT
<213>  Homo Sapiens

<400>  1255

Met Ala Val Phe Val Val Leu Leu Ala Leu Val Ala Gly Val Leu Gly 
1               5                   10                  15      


Asn Glu Phe Ser Ile Leu Lys Ser Pro Gly Ser Val Val Phe Arg Asn 
            20                  25                  30          


Gly Asn Trp Pro Ile Pro Gly Glu Arg Ile Pro Asp Val Ala Ala Leu 
        35                  40                  45              


Ser Met Gly Phe Ser Val Lys Glu Asp Leu Ser Trp Pro Gly Leu Ala 
    50                  55                  60                  


Val Gly Asn Leu Phe His Arg Pro Arg Ala Thr Val Met Val Met Val 
65                  70                  75                  80  


Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser Tyr 
                85                  90                  95      


Pro Leu Glu Asn Arg Val Tyr Met Val Gly Lys Ala Asn Ser Val Phe 
            100                 105                 110         


Glu Asp Leu Ser Val Thr Leu Arg Gln Leu Arg Asn Arg Leu Phe Gln 
        115                 120                 125             


Glu Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser Leu Ser Arg Asn 
    130                 135                 140                 


Asn Glu Val Asp Leu Leu Phe Leu Ser Glu Leu Gln Val Leu His Asp 
145                 150                 155                 160 


Ile Ser Ser Leu Leu Ser Arg His Lys His Leu Ala Lys Asp His Ser 
                165                 170                 175     


Pro Asp Leu Tyr Ser Leu Glu Leu Ala Gly Leu Asp Glu Ile Gly Lys 
            180                 185                 190         


Arg Tyr Gly Glu Asp Ser Glu Gln Phe Arg Asp Ala Ser Lys Ile Leu 
        195                 200                 205             


Val Asp Ala Leu Gln Lys Phe Ala Asp Asp Met Tyr Ser Leu Tyr Gly 
    210                 215                 220                 


Gly Asn Ala Val Val Glu Leu Val Thr Val Lys Ser Phe Asp Thr Ser 
225                 230                 235                 240 


Leu Ile Arg Lys Thr Arg Thr Ile Leu Glu Ala Lys Gln Ala Lys Asn 
                245                 250                 255     


Pro Ala Ser Pro Tyr Asn Leu Ala Tyr Lys Tyr Asn Phe Glu Tyr Ser 
            260                 265                 270         


Val Val Phe Asn Met Val Leu Trp Ile Met Ile Ala Leu Ala Leu Ala 
        275                 280                 285             


Val Ile Ile Thr Ser Tyr Asn Ile Trp Asn Met Asp Pro Gly Tyr Asp 
    290                 295                 300                 


Ser Ile Ile Tyr Arg Met Thr Asn Gln Lys Ile Arg Met Asp 
305                 310                 315             


<210>  1256
<211>  317
<212>  PRT
<213>  Homo Sapiens

<400>  1256

Met Ala Val Phe Val Val Leu Leu Ala Leu Val Ala Gly Val Leu Gly 
1               5                   10                  15      


Asn Glu Phe Ser Ile Leu Lys Ser Pro Gly Ser Val Val Phe Arg Asn 
            20                  25                  30          


Gly Asn Trp Pro Ile Pro Gly Glu Arg Ile Pro Asp Val Ala Ala Leu 
        35                  40                  45              


Ser Met Gly Phe Ser Val Lys Glu Asp Leu Ser Trp Pro Gly Leu Ala 
    50                  55                  60                  


Val Gly Asn Leu Phe His Arg Pro Arg Ala Thr Val Met Val Met Val 
65                  70                  75                  80  


Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser Tyr 
                85                  90                  95      


Pro Leu Glu Asn Arg Val Tyr Met Val Gly Lys Ala Asn Ser Val Phe 
            100                 105                 110         


Glu Asp Leu Ser Val Thr Leu Arg Gln Leu Arg Asn Arg Leu Phe Gln 
        115                 120                 125             


Glu Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser Leu Ser Arg Asn 
    130                 135                 140                 


Asn Glu Val Asp Leu Leu Phe Leu Ser Glu Leu Gln Val Leu His Asp 
145                 150                 155                 160 


Ile Ser Ser Leu Leu Ser Arg His Lys His Leu Ala Lys Asp His Ser 
                165                 170                 175     


Pro Asp Leu Tyr Ser Leu Glu Leu Ala Gly Leu Asp Glu Ile Gly Lys 
            180                 185                 190         


Arg Tyr Gly Glu Asp Ser Glu Gln Phe Arg Asp Ala Ser Lys Ile Leu 
        195                 200                 205             


Val Asp Ala Leu Gln Lys Phe Ala Asp Asp Met Tyr Ser Leu Tyr Gly 
    210                 215                 220                 


Gly Asn Ala Val Val Glu Leu Val Thr Val Lys Ser Phe Asp Thr Ser 
225                 230                 235                 240 


Leu Ile Arg Lys Thr Arg Thr Ile Leu Glu Ala Lys Gln Ala Asn Pro 
                245                 250                 255     


Ala Ser Pro Tyr Asn Leu Ala Tyr Lys Tyr Asn Phe Glu Tyr Ser Val 
            260                 265                 270         


Val Phe Asn Met Val Leu Trp Ile Met Ile Ala Leu Ala Leu Ala Val 
        275                 280                 285             


Ile Ile Thr Ser Tyr Asn Ile Trp Asn Met Asp Pro Gly Tyr Asp Ser 
    290                 295                 300                 


Ile Ile Tyr Arg Met Thr Asn Gln Lys Ile Arg Met Asp 
305                 310                 315         


<210>  1257
<211>  272
<212>  PRT
<213>  Homo Sapiens

<400>  1257

Met Ala Val Phe Val Val Leu Leu Ala Leu Val Ala Gly Val Leu Gly 
1               5                   10                  15      


Asn Glu Phe Ser Ile Leu Lys Ser Pro Gly Ser Val Val Phe Arg Asn 
            20                  25                  30          


Gly Asn Trp Pro Ile Pro Gly Glu Arg Ile Pro Asp Val Ala Ala Leu 
        35                  40                  45              


Ser Met Gly Phe Ser Val Lys Glu Asp Leu Ser Trp Pro Gly Leu Ala 
    50                  55                  60                  


Val Gly Asn Leu Phe His Arg Pro Arg Ala Thr Val Met Val Met Val 
65                  70                  75                  80  


Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser Tyr 
                85                  90                  95      


Pro Leu Glu Asn Val Asp Leu Leu Phe Leu Ser Glu Leu Gln Val Leu 
            100                 105                 110         


His Asp Ile Ser Ser Leu Leu Ser Arg His Lys His Leu Ala Lys Asp 
        115                 120                 125             


His Ser Pro Asp Leu Tyr Ser Leu Glu Leu Ala Gly Leu Asp Glu Ile 
    130                 135                 140                 


Gly Lys Arg Tyr Gly Glu Asp Ser Glu Gln Phe Arg Asp Ala Ser Lys 
145                 150                 155                 160 


Ile Leu Val Asp Ala Leu Gln Lys Phe Ala Asp Asp Met Tyr Ser Leu 
                165                 170                 175     


Tyr Gly Gly Asn Ala Val Val Glu Leu Val Thr Val Lys Ser Phe Asp 
            180                 185                 190         


Thr Ser Leu Ile Arg Lys Thr Arg Thr Ile Leu Glu Ala Lys Gln Ala 
        195                 200                 205             


Lys Asn Pro Ala Ser Pro Tyr Asn Leu Ala Tyr Lys Tyr Asn Phe Glu 
    210                 215                 220                 


Tyr Ser Val Val Phe Asn Met Val Leu Trp Ile Met Ile Ala Leu Ala 
225                 230                 235                 240 


Leu Ala Val Ile Ile Thr Ser Tyr Asn Ile Trp Asn Met Asp Pro Gly 
                245                 250                 255     


Tyr Asp Ser Ile Ile Tyr Arg Met Thr Asn Gln Lys Ile Arg Met Asp 
            260                 265                 270         


<210>  1258
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  1258

Met Gly Phe Ser Val Lys Glu Asp Leu Ser Trp Pro Gly Leu Ala Val 
1               5                   10                  15      


Gly Asn Leu Phe His Arg Pro Arg Ala Thr Val Met Val Met Val Lys 
            20                  25                  30          


Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser Tyr Pro 
        35                  40                  45              


Leu Glu Asn Ala Val Pro Phe Ser Leu Asp Ser Val Ala Asn Ser Ile 
    50                  55                  60                  


His Ser Leu Phe Ser Glu Glu Thr Pro Val Val Leu Gln Leu Ala Pro 
65                  70                  75                  80  


Ser Glu Glu Arg Val Tyr Met Val Gly Lys Ala Asn Ser Val Phe Glu 
                85                  90                  95      


Asp Leu Ser Val Thr Leu Arg Gln Leu Arg Asn Arg Leu Phe Gln Glu 
            100                 105                 110         


Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser Leu Ser Arg Asn Asn 
        115                 120                 125             


<210>  1259
<211>  301
<212>  PRT
<213>  Homo Sapiens

<400>  1259

Met Gly Phe Ser Val Lys Glu Asp Leu Ser Trp Pro Gly Leu Ala Val 
1               5                   10                  15      


Gly Asn Leu Phe His Arg Pro Arg Ala Thr Val Met Val Met Val Lys 
            20                  25                  30          


Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser Tyr Pro 
        35                  40                  45              


Leu Glu Asn Ala Val Pro Phe Ser Leu Asp Ser Val Ala Asn Ser Ile 
    50                  55                  60                  


His Ser Leu Phe Ser Glu Glu Thr Pro Val Val Leu Gln Leu Ala Pro 
65                  70                  75                  80  


Ser Glu Glu Arg Val Tyr Met Val Gly Lys Ala Asn Ser Val Phe Glu 
                85                  90                  95      


Asp Leu Ser Val Thr Leu Arg Gln Leu Arg Asn Arg Leu Phe Gln Glu 
            100                 105                 110         


Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser Leu Ser Arg Asn Asn 
        115                 120                 125             


Glu Val Asp Leu Leu Phe Leu Ser Glu Leu Gln Val Leu His Asp Ile 
    130                 135                 140                 


Ser Ser Leu Leu Ser Arg His Lys His Leu Ala Lys Asp His Ser Pro 
145                 150                 155                 160 


Asp Leu Tyr Ser Leu Glu Leu Ala Gly Leu Asp Glu Ile Gly Lys Arg 
                165                 170                 175     


Tyr Gly Glu Asp Ser Glu Gln Phe Arg Asp Ala Ser Lys Ile Leu Val 
            180                 185                 190         


Asp Ala Leu Gln Lys Phe Ala Asp Asp Met Tyr Ser Leu Tyr Gly Gly 
        195                 200                 205             


Asn Ala Val Val Glu Leu Val Thr Val Lys Ser Phe Asp Thr Ser Leu 
    210                 215                 220                 


Ile Arg Lys Thr Arg Thr Ile Leu Glu Ala Lys Gln Ala Lys Asn Pro 
225                 230                 235                 240 


Ala Ser Pro Tyr Asn Leu Ala Tyr Lys Tyr Asn Phe Glu Tyr Ser Val 
                245                 250                 255     


Val Phe Asn Met Val Leu Trp Ile Met Ile Ala Leu Ala Leu Ala Val 
            260                 265                 270         


Ile Ile Thr Ser Tyr Asn Ile Trp Asn Met Asp Pro Gly Tyr Asp Ser 
        275                 280                 285             


Ile Ile Tyr Arg Met Thr Asn Gln Lys Ile Arg Met Asp 
    290                 295                 300     


<210>  1260
<211>  274
<212>  PRT
<213>  Homo Sapiens

<400>  1260

Met Val Met Val Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser 
1               5                   10                  15      


Val Ile Ser Tyr Pro Leu Glu Asn Ala Val Pro Phe Ser Leu Asp Ser 
            20                  25                  30          


Val Ala Asn Ser Ile His Ser Leu Phe Ser Glu Glu Thr Pro Val Val 
        35                  40                  45              


Leu Gln Leu Ala Pro Ser Glu Glu Arg Val Tyr Met Val Gly Lys Ala 
    50                  55                  60                  


Asn Ser Val Phe Glu Asp Leu Ser Val Thr Leu Arg Gln Leu Arg Asn 
65                  70                  75                  80  


Arg Leu Phe Gln Glu Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser 
                85                  90                  95      


Leu Ser Arg Asn Asn Glu Val Asp Leu Leu Phe Leu Ser Glu Leu Gln 
            100                 105                 110         


Val Leu His Asp Ile Ser Ser Leu Leu Ser Arg His Lys His Leu Ala 
        115                 120                 125             


Lys Asp His Ser Pro Asp Leu Tyr Ser Leu Glu Leu Ala Gly Leu Asp 
    130                 135                 140                 


Glu Ile Gly Lys Arg Tyr Gly Glu Asp Ser Glu Gln Phe Arg Asp Ala 
145                 150                 155                 160 


Ser Lys Ile Leu Val Asp Ala Leu Gln Lys Phe Ala Asp Asp Met Tyr 
                165                 170                 175     


Ser Leu Tyr Gly Gly Asn Ala Val Val Glu Leu Val Thr Val Lys Ser 
            180                 185                 190         


Phe Asp Thr Ser Leu Ile Arg Lys Thr Arg Thr Ile Leu Glu Ala Lys 
        195                 200                 205             


Gln Ala Lys Asn Pro Ala Ser Pro Tyr Asn Leu Ala Tyr Lys Tyr Asn 
    210                 215                 220                 


Phe Glu Tyr Ser Val Val Phe Asn Met Val Leu Trp Ile Met Ile Ala 
225                 230                 235                 240 


Leu Ala Leu Ala Val Ile Ile Thr Ser Tyr Asn Ile Trp Asn Met Asp 
                245                 250                 255     


Pro Gly Tyr Asp Ser Ile Ile Tyr Arg Met Thr Asn Gln Lys Ile Arg 
            260                 265                 270         


Met Asp 
        


<210>  1261
<211>  273
<212>  PRT
<213>  Homo Sapiens

<400>  1261

Met Val Met Val Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser 
1               5                   10                  15      


Val Ile Ser Tyr Pro Leu Glu Asn Ala Val Pro Phe Ser Leu Asp Ser 
            20                  25                  30          


Val Ala Asn Ser Ile His Ser Leu Phe Ser Glu Glu Thr Pro Val Val 
        35                  40                  45              


Leu Gln Leu Ala Pro Ser Glu Glu Arg Val Tyr Met Val Gly Lys Ala 
    50                  55                  60                  


Asn Ser Val Phe Glu Asp Leu Ser Val Thr Leu Arg Gln Leu Arg Asn 
65                  70                  75                  80  


Arg Leu Phe Gln Glu Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser 
                85                  90                  95      


Leu Ser Arg Asn Asn Glu Val Asp Leu Leu Phe Leu Ser Glu Leu Gln 
            100                 105                 110         


Val Leu His Asp Ile Ser Ser Leu Leu Ser Arg His Lys His Leu Ala 
        115                 120                 125             


Lys Asp His Ser Pro Asp Leu Tyr Ser Leu Glu Leu Ala Gly Leu Asp 
    130                 135                 140                 


Glu Ile Gly Lys Arg Tyr Gly Glu Asp Ser Glu Gln Phe Arg Asp Ala 
145                 150                 155                 160 


Ser Lys Ile Leu Val Asp Ala Leu Gln Lys Phe Ala Asp Asp Met Tyr 
                165                 170                 175     


Ser Leu Tyr Gly Gly Asn Ala Val Val Glu Leu Val Thr Val Lys Ser 
            180                 185                 190         


Phe Asp Thr Ser Leu Ile Arg Lys Thr Arg Thr Ile Leu Glu Ala Lys 
        195                 200                 205             


Gln Ala Asn Pro Ala Ser Pro Tyr Asn Leu Ala Tyr Lys Tyr Asn Phe 
    210                 215                 220                 


Glu Tyr Ser Val Val Phe Asn Met Val Leu Trp Ile Met Ile Ala Leu 
225                 230                 235                 240 


Ala Leu Ala Val Ile Ile Thr Ser Tyr Asn Ile Trp Asn Met Asp Pro 
                245                 250                 255     


Gly Tyr Asp Ser Ile Ile Tyr Arg Met Thr Asn Gln Lys Ile Arg Met 
            260                 265                 270         


Asp 
    


<210>  1262
<211>  59
<212>  PRT
<213>  Homo Sapiens

<400>  1262

Met Val Met Val Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser 
1               5                   10                  15      


Val Ile Ser Tyr Pro Leu Glu Asn Phe Leu Leu Val Leu Thr Val Leu 
            20                  25                  30          


Gln Ile Pro Phe Thr Pro Tyr Phe Leu Arg Lys Leu Leu Leu Phe Cys 
        35                  40                  45              


Ser Trp Leu Pro Val Arg Lys Glu Cys Ile Trp 
    50                  55                  


<210>  1263
<211>  101
<212>  PRT
<213>  Homo Sapiens

<400>  1263

Met Val Met Val Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser 
1               5                   10                  15      


Val Ile Ser Tyr Pro Leu Glu Asn Arg Val Tyr Met Val Gly Lys Ala 
            20                  25                  30          


Asn Ser Val Phe Glu Asp Leu Ser Val Thr Leu Arg Gln Leu Arg Asn 
        35                  40                  45              


Arg Leu Phe Gln Glu Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser 
    50                  55                  60                  


Leu Ser Arg Asn Asn Glu Val Asp Leu Leu Phe Leu Ser Glu Leu Gln 
65                  70                  75                  80  


Val Leu His Asp Ile Ser Ser Leu Gly Glu Thr Thr Tyr Leu Pro Arg 
                85                  90                  95      


Thr Gln Ala Trp Ala 
            100     


<210>  1264
<211>  242
<212>  PRT
<213>  Homo Sapiens

<400>  1264

Met Val Met Val Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser 
1               5                   10                  15      


Val Ile Ser Tyr Pro Leu Glu Asn Arg Val Tyr Met Val Gly Lys Ala 
            20                  25                  30          


Asn Ser Val Phe Glu Asp Leu Ser Val Thr Leu Arg Gln Leu Arg Asn 
        35                  40                  45              


Arg Leu Phe Gln Glu Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser 
    50                  55                  60                  


Leu Ser Arg Asn Asn Glu Val Asp Leu Leu Phe Leu Ser Glu Leu Gln 
65                  70                  75                  80  


Val Leu His Asp Ile Ser Ser Leu Leu Ser Arg His Lys His Leu Ala 
                85                  90                  95      


Lys Asp His Ser Pro Asp Leu Tyr Ser Leu Glu Leu Ala Gly Leu Asp 
            100                 105                 110         


Glu Ile Gly Lys Arg Tyr Gly Glu Asp Ser Glu Gln Phe Arg Asp Ala 
        115                 120                 125             


Ser Lys Ile Leu Val Asp Ala Leu Gln Lys Phe Ala Asp Asp Met Tyr 
    130                 135                 140                 


Ser Leu Tyr Gly Gly Asn Ala Val Val Glu Leu Val Thr Val Lys Ser 
145                 150                 155                 160 


Phe Asp Thr Ser Leu Ile Arg Lys Thr Arg Thr Ile Leu Glu Ala Lys 
                165                 170                 175     


Gln Ala Lys Asn Pro Ala Ser Pro Tyr Asn Leu Ala Tyr Lys Tyr Asn 
            180                 185                 190         


Phe Glu Tyr Ser Val Val Phe Asn Met Val Leu Trp Ile Met Ile Ala 
        195                 200                 205             


Leu Ala Leu Ala Val Ile Ile Thr Ser Tyr Asn Ile Trp Asn Met Asp 
    210                 215                 220                 


Pro Gly Tyr Asp Ser Ile Ile Tyr Arg Met Thr Asn Gln Lys Ile Arg 
225                 230                 235                 240 


Met Asp 
        


<210>  1265
<211>  196
<212>  PRT
<213>  Homo Sapiens

<400>  1265

Met Val Met Val Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser 
1               5                   10                  15      


Val Ile Ser Tyr Pro Leu Glu Asn Val Asp Leu Leu Phe Leu Ser Glu 
            20                  25                  30          


Leu Gln Val Leu His Asp Ile Ser Ser Leu Leu Ser Arg His Lys His 
        35                  40                  45              


Leu Ala Lys Asp His Ser Pro Asp Leu Tyr Ser Leu Glu Leu Ala Gly 
    50                  55                  60                  


Leu Asp Glu Ile Gly Lys Arg Tyr Gly Glu Asp Ser Glu Gln Phe Arg 
65                  70                  75                  80  


Asp Ala Ser Lys Ile Leu Val Asp Ala Leu Gln Lys Phe Ala Asp Asp 
                85                  90                  95      


Met Tyr Ser Leu Tyr Gly Gly Asn Ala Val Val Glu Leu Val Thr Val 
            100                 105                 110         


Lys Ser Phe Asp Thr Ser Leu Ile Arg Lys Thr Arg Thr Ile Leu Glu 
        115                 120                 125             


Ala Lys Gln Ala Lys Asn Pro Ala Ser Pro Tyr Asn Leu Ala Tyr Lys 
    130                 135                 140                 


Tyr Asn Phe Glu Tyr Ser Val Val Phe Asn Met Val Leu Trp Ile Met 
145                 150                 155                 160 


Ile Ala Leu Ala Leu Ala Val Ile Ile Thr Ser Tyr Asn Ile Trp Asn 
                165                 170                 175     


Met Asp Pro Gly Tyr Asp Ser Ile Ile Tyr Arg Met Thr Asn Gln Lys 
            180                 185                 190         


Ile Arg Met Asp 
        195     


<210>  1266
<211>  294
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1266

Xaa Glu Phe Ser Ile Leu Lys Ser Pro Gly Ser Val Val Phe Arg Asn 
1               5                   10                  15      


Gly Asn Trp Pro Ile Pro Gly Glu Arg Ile Pro Asp Val Ala Ala Leu 
            20                  25                  30          


Ser Met Gly Phe Ser Val Lys Glu Asp Leu Ser Trp Pro Gly Leu Ala 
        35                  40                  45              


Val Gly Asn Leu Phe His Arg Pro Arg Ala Thr Val Met Val Met Val 
    50                  55                  60                  


Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser Tyr 
65                  70                  75                  80  


Pro Leu Glu Asn Ala Val Pro Phe Ser Leu Asp Ser Val Ala Asn Ser 
                85                  90                  95      


Ile His Ser Leu Phe Ser Glu Glu Thr Pro Val Val Leu Gln Leu Ala 
            100                 105                 110         


Pro Ser Glu Glu Arg Val Tyr Met Val Gly Lys Ala Asn Ser Val Phe 
        115                 120                 125             


Glu Asp Leu Ser Val Thr Leu Arg Gln Leu Arg Asn Arg Leu Phe Gln 
    130                 135                 140                 


Glu Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser Leu Ser Arg Asn 
145                 150                 155                 160 


Asn Glu Val Asp Leu Leu Phe Leu Ser Glu Leu Gln Val Leu His Asp 
                165                 170                 175     


Ile Ser Ser Leu Leu Ser Arg His Lys His Leu Ala Lys Asp His Ser 
            180                 185                 190         


Pro Asp Leu Tyr Ser Leu Glu Leu Ala Gly Leu Asp Glu Ile Gly Lys 
        195                 200                 205             


Arg Tyr Gly Glu Asp Ser Glu Gln Phe Arg Asp Ala Ser Lys Ile Leu 
    210                 215                 220                 


Val Asp Ala Leu Gln Lys Lys Asn Pro Ala Ser Pro Tyr Asn Leu Ala 
225                 230                 235                 240 


Tyr Lys Tyr Asn Phe Glu Tyr Ser Val Val Phe Asn Met Val Leu Trp 
                245                 250                 255     


Ile Met Ile Ala Leu Ala Leu Ala Val Ile Ile Thr Ser Tyr Asn Ile 
            260                 265                 270         


Trp Asn Met Asp Pro Gly Tyr Asp Ser Ile Ile Tyr Arg Met Thr Asn 
        275                 280                 285             


Gln Lys Ile Arg Met Asp 
    290                 


<210>  1267
<211>  76
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1267

Xaa Ser Leu Tyr Gly Gly Asn Ala Val Val Glu Leu Val Thr Val Lys 
1               5                   10                  15      


Ser Phe Asp Thr Ser Leu Ile Arg Lys Thr Arg Thr Ile Leu Glu Ala 
            20                  25                  30          


Lys Gln Ala Glu Lys Glu His Val Tyr Gln Lys Lys Lys Lys Glu Arg 
        35                  40                  45              


Asn Lys Glu Val Phe Met Gly Val Lys Ser Phe Asn Val Cys Leu Ser 
    50                  55                  60                  


Ser Glu Leu Pro Ala Glu Glu Pro Ser Lys Ser Leu 
65                  70                  75      


<210>  1268
<211>  113
<212>  PRT
<213>  Homo Sapiens

<400>  1268

Phe Leu Cys Ala Leu Pro Arg Arg Glu Gly Tyr Glu Phe Phe Val Gly 
1               5                   10                  15      


Gln Trp Thr Gly Thr Glu Leu His Phe Thr Ala Leu Ile Asn Ile Gln 
            20                  25                  30          


Thr Arg Gly Glu Ala Ala Ala Ser Gln Leu Ile Leu Tyr His Tyr Pro 
        35                  40                  45              


Glu Leu Lys Glu Glu Lys Gly Ile Val Leu Met Thr Ala Glu Met Asp 
    50                  55                  60                  


Ser Thr Phe Leu Asn Val Ala Glu Ala Gln Cys Ile Ala Asn Gln Val 
65                  70                  75                  80  


Gln Leu Phe Tyr Ala Thr Asp Arg Lys Glu Thr Tyr Gly Trp Ala Gln 
                85                  90                  95      


Leu Leu Ala Ile His Ser Thr Leu Ile His Leu His Gln Arg Val Arg 
            100                 105                 110         


Lys 
    


<210>  1269
<211>  174
<212>  PRT
<213>  Homo Sapiens

<400>  1269

Leu Ile Arg Ser Asp Pro Ala Ala Phe Glu Ser Arg Leu Glu Lys Arg 
1               5                   10                  15      


Ser Glu Phe Arg Lys Gln Pro Val Gly His Ser Arg Gln Gly Asp Phe 
            20                  25                  30          


Ile Lys Cys Val Glu Gln Lys Thr Asp Ala Leu Gly Lys Gln Ser Val 
        35                  40                  45              


Asn Arg Gly Phe Thr Lys Asp Lys Thr Leu Ser Ser Ile Phe Asn Ile 
    50                  55                  60                  


Glu Met Val Lys Glu Lys Thr Ala Glu Glu Ile Lys Gln Ile Trp Gln 
65                  70                  75                  80  


Gln Tyr Phe Ala Ala Lys Asp Thr Val Tyr Ala Val Ile Pro Ala Glu 
                85                  90                  95      


Lys Phe Asp Leu Ile Trp Asn Arg Ala Gln Ser Cys Pro Thr Asn Val 
            100                 105                 110         


Ala Glu Ala Gln Cys Ile Ala Asn Gln Val Gln Leu Phe Tyr Ala Thr 
        115                 120                 125             


Asp Arg Lys Glu Thr Tyr Gly Leu Val Glu Thr Phe Asn Leu Arg Pro 
    130                 135                 140                 


Asn Glu Phe Lys Tyr Met Ser Val Ile Ala Glu Leu Glu Gln Ser Gly 
145                 150                 155                 160 


Leu Gly Ala Glu Leu Lys Cys Ala Gln Asn Gln Asn Lys Thr 
                165                 170                 


<210>  1270
<211>  328
<212>  PRT
<213>  Homo Sapiens

<400>  1270

Met Ala Ala Val Val Val Ala Ala Ala Gly Gly Ala Gly Pro Ala Val 
1               5                   10                  15      


Leu Gln Val Ala Gly Leu Tyr Arg Gly Leu Cys Ala Val Arg Ser Arg 
            20                  25                  30          


Ala Leu Gly Leu Gly Leu Val Ser Pro Ala Gln Leu Arg Val Phe Pro 
        35                  40                  45              


Val Arg Pro Gly Ser Gly Arg Pro Glu Gly Gly Ala Asp Ser Ser Gly 
    50                  55                  60                  


Val Gly Ala Glu Ala Glu Leu Gln Ala Asn Pro Phe Tyr Asp Arg Tyr 
65                  70                  75                  80  


Arg Asp Lys Ile Gln Leu Leu Arg Arg Ser Asp Pro Ala Ala Phe Glu 
                85                  90                  95      


Ser Arg Leu Glu Lys Arg Ser Glu Phe Arg Lys Gln Pro Val Gly His 
            100                 105                 110         


Ser Arg Gln Gly Asp Phe Ile Lys Cys Val Glu Gln Lys Thr Asp Ala 
        115                 120                 125             


Leu Gly Lys Gln Ser Val Asn Arg Gly Phe Thr Lys Asp Lys Thr Leu 
    130                 135                 140                 


Ser Ser Ile Phe Asn Ile Glu Met Val Lys Glu Lys Thr Ala Glu Glu 
145                 150                 155                 160 


Ile Lys Gln Ile Trp Gln Gln Tyr Phe Ala Ala Lys Asp Thr Val Tyr 
                165                 170                 175     


Ala Val Ile Pro Ala Glu Lys Phe Asp Leu Ile Trp Asn Arg Ala Gln 
            180                 185                 190         


Ser Cys Pro Thr Phe Leu Cys Ala Leu Pro Arg Arg Glu Gly Tyr Glu 
        195                 200                 205             


Phe Phe Val Gly Gln Trp Thr Gly Thr Glu Leu His Phe Thr Ala Leu 
    210                 215                 220                 


Ile Asn Ile Gln Thr Arg Gly Glu Ala Ala Ala Ser Gln Leu Ile Leu 
225                 230                 235                 240 


Tyr His Tyr Pro Glu Leu Lys Glu Glu Lys Gly Ile Val Leu Met Thr 
                245                 250                 255     


Ala Glu Met Asp Ser Thr Phe Leu Asn Val Ala Glu Ala Gln Cys Ile 
            260                 265                 270         


Ala Asn Gln Val Gln Leu Phe Tyr Ala Thr Asp Arg Lys Glu Thr Tyr 
        275                 280                 285             


Gly Leu Val Glu Thr Phe Asn Leu Arg Pro Asn Glu Phe Lys Tyr Met 
    290                 295                 300                 


Ser Val Ile Ala Glu Leu Glu Gln Ser Gly Leu Gly Ala Glu Leu Lys 
305                 310                 315                 320 


Cys Ala Gln Asn Gln Asn Lys Thr 
                325             


<210>  1271
<211>  351
<212>  PRT
<213>  Homo Sapiens

<400>  1271

Met Glu Arg Ala Arg Gly Pro Arg Ala Glu Ala Asp Ala Pro Glu Glu 
1               5                   10                  15      


Glu Glu Glu Ala Gly Ala Ala Met Ala Ala Val Val Val Ala Ala Ala 
            20                  25                  30          


Gly Gly Ala Gly Pro Ala Val Leu Gln Val Ala Gly Leu Tyr Arg Gly 
        35                  40                  45              


Leu Cys Ala Val Arg Ser Arg Ala Leu Gly Leu Gly Leu Val Ser Pro 
    50                  55                  60                  


Ala Gln Leu Arg Val Phe Pro Val Arg Pro Gly Ser Gly Arg Pro Glu 
65                  70                  75                  80  


Gly Gly Ala Asp Ser Ser Gly Val Gly Ala Glu Ala Glu Leu Gln Ala 
                85                  90                  95      


Asn Pro Phe Tyr Asp Arg Tyr Arg Asp Lys Ile Gln Leu Leu Arg Arg 
            100                 105                 110         


Ser Asp Pro Ala Ala Phe Glu Ser Arg Leu Glu Lys Arg Ser Glu Phe 
        115                 120                 125             


Arg Lys Gln Pro Val Gly His Ser Arg Gln Gly Asp Phe Ile Lys Cys 
    130                 135                 140                 


Val Glu Gln Lys Thr Asp Ala Leu Gly Lys Gln Ser Val Asn Arg Gly 
145                 150                 155                 160 


Phe Thr Lys Asp Lys Thr Leu Ser Ser Ile Phe Asn Ile Glu Met Val 
                165                 170                 175     


Lys Glu Lys Thr Ala Glu Glu Ile Lys Gln Ile Trp Gln Gln Tyr Phe 
            180                 185                 190         


Ala Ala Lys Asp Thr Val Tyr Ala Val Ile Pro Ala Glu Lys Phe Asp 
        195                 200                 205             


Leu Ile Trp Asn Arg Ala Gln Ser Cys Pro Thr Phe Leu Cys Ala Leu 
    210                 215                 220                 


Pro Arg Arg Glu Gly Tyr Glu Phe Phe Val Gly Gln Trp Thr Gly Thr 
225                 230                 235                 240 


Glu Leu His Phe Thr Ala Leu Ile Asn Ile Gln Thr Arg Gly Glu Ala 
                245                 250                 255     


Ala Ala Ser Gln Leu Ile Leu Tyr His Tyr Pro Glu Leu Lys Glu Glu 
            260                 265                 270         


Lys Gly Ile Val Leu Met Thr Ala Glu Met Asp Ser Thr Phe Leu Asn 
        275                 280                 285             


Val Ala Glu Ala Gln Cys Ile Ala Asn Gln Val Gln Leu Phe Tyr Ala 
    290                 295                 300                 


Thr Asp Arg Lys Glu Thr Tyr Gly Leu Val Glu Thr Phe Asn Leu Arg 
305                 310                 315                 320 


Pro Asn Glu Phe Lys Tyr Met Ser Val Ile Ala Glu Leu Glu Gln Ser 
                325                 330                 335     


Gly Leu Gly Ala Glu Leu Lys Cys Ala Gln Asn Gln Asn Lys Thr 
            340                 345                 350     


<210>  1272
<211>  351
<212>  PRT
<213>  Homo Sapiens

<400>  1272

Met Glu Arg Ala Arg Gly Pro Arg Ala Glu Ala Asp Ala Pro Glu Glu 
1               5                   10                  15      


Glu Glu Glu Ala Gly Ala Ala Met Ala Ala Val Val Val Ala Ala Ala 
            20                  25                  30          


Gly Gly Ala Gly Pro Ala Val Leu Gln Val Ala Gly Leu Tyr Arg Gly 
        35                  40                  45              


Leu Cys Ala Val Arg Ser Arg Ala Leu Gly Leu Gly Leu Val Ser Pro 
    50                  55                  60                  


Ala Gln Leu Arg Val Phe Pro Val Arg Pro Gly Ser Gly Arg Pro Glu 
65                  70                  75                  80  


Gly Gly Ala Asp Ser Ser Gly Val Gly Ala Glu Ala Glu Leu Gln Ala 
                85                  90                  95      


Asn Pro Phe Tyr Asp Arg Tyr Arg Asp Lys Ile Gln Leu Leu Arg Arg 
            100                 105                 110         


Ser Asp Pro Ala Ala Phe Glu Ser Arg Leu Glu Lys Arg Ser Glu Phe 
        115                 120                 125             


Arg Lys Gln Pro Val Gly His Ser Arg Gln Gly Asp Phe Ile Lys Cys 
    130                 135                 140                 


Val Glu Gln Lys Thr Asp Ala Leu Gly Lys Gln Ser Val Asn Arg Gly 
145                 150                 155                 160 


Phe Thr Lys Asp Lys Thr Leu Ser Ser Ile Phe Asn Ile Glu Met Val 
                165                 170                 175     


Lys Glu Lys Thr Ala Glu Glu Ile Lys Gln Ile Trp Gln Gln Tyr Phe 
            180                 185                 190         


Ala Ala Lys Asp Thr Val Tyr Ala Val Ile Pro Ala Glu Lys Phe Asp 
        195                 200                 205             


Leu Ile Trp Asn Arg Ala Gln Ser Cys Pro Thr Phe Leu Cys Ala Leu 
    210                 215                 220                 


Pro Arg Arg Glu Gly Tyr Glu Phe Phe Val Gly Gln Trp Thr Gly Thr 
225                 230                 235                 240 


Glu Leu His Phe Thr Ala Leu Ile Asn Ile Gln Thr Arg Gly Glu Ala 
                245                 250                 255     


Ala Ala Ser Gln Leu Ile Leu Tyr His Tyr Pro Glu Leu Lys Glu Glu 
            260                 265                 270         


Lys Gly Ile Val Leu Met Thr Ala Glu Met Asp Ser Thr Phe Leu Asn 
        275                 280                 285             


Val Ala Glu Ala Gln Cys Ile Ala Asn Gln Val Gln Leu Phe Tyr Ala 
    290                 295                 300                 


Thr Asp Arg Lys Glu Thr Tyr Gly Leu Val Glu Thr Phe Asn Leu Arg 
305                 310                 315                 320 


Pro Asn Glu Phe Lys Tyr Met Ser Val Ile Ala Glu Leu Glu Gln Ser 
                325                 330                 335     


Gly Leu Gly Ala Glu Leu Lys Cys Ala Gln Asn Gln Asn Lys Thr 
            340                 345                 350     


<210>  1273
<211>  283
<212>  PRT
<213>  Homo Sapiens

<400>  1273

Met Glu Arg Ala Arg Gly Pro Arg Ala Glu Ala Asp Ala Pro Glu Glu 
1               5                   10                  15      


Glu Glu Glu Ala Gly Ala Ala Met Ala Ala Val Val Val Ala Ala Ala 
            20                  25                  30          


Gly Gly Ala Gly Pro Ala Val Leu Gln Val Ala Gly Leu Tyr Arg Gly 
        35                  40                  45              


Leu Cys Ala Val Arg Ser Arg Ala Leu Gly Leu Gly Leu Val Ser Pro 
    50                  55                  60                  


Ala Gln Leu Arg Val Phe Pro Val Arg Pro Gly Ser Gly Arg Pro Glu 
65                  70                  75                  80  


Gly Gly Ala Asp Ser Ser Gly Val Gly Ala Glu Ala Glu Leu Gln Ala 
                85                  90                  95      


Asn Pro Phe Tyr Asp Arg Tyr Arg Asp Lys Ile Gln Leu Leu Arg Arg 
            100                 105                 110         


Ser Asp Pro Ala Ala Phe Glu Ser Arg Leu Glu Lys Arg Ser Glu Phe 
        115                 120                 125             


Arg Lys Gln Pro Val Gly His Ser Arg Gln Gly Asp Phe Ile Lys Cys 
    130                 135                 140                 


Val Glu Gln Lys Thr Asp Ala Leu Gly Lys Gln Ser Val Asn Arg Gly 
145                 150                 155                 160 


Phe Thr Lys Asp Lys Thr Leu Ser Ser Ile Phe Asn Ile Glu Met Val 
                165                 170                 175     


Lys Glu Lys Thr Ala Glu Glu Ile Lys Gln Ile Trp Gln Gln Tyr Phe 
            180                 185                 190         


Ala Ala Lys Asp Thr Val Tyr Ala Val Ile Pro Ala Glu Lys Phe Asp 
        195                 200                 205             


Leu Ile Trp Asn Arg Ala Gln Ser Cys Pro Thr Asn Val Ala Glu Ala 
    210                 215                 220                 


Gln Cys Ile Ala Asn Gln Val Gln Leu Phe Tyr Ala Thr Asp Arg Lys 
225                 230                 235                 240 


Glu Thr Tyr Gly Leu Val Glu Thr Phe Asn Leu Arg Pro Asn Glu Phe 
                245                 250                 255     


Lys Tyr Met Ser Val Ile Ala Glu Leu Glu Gln Ser Gly Leu Gly Ala 
            260                 265                 270         


Glu Leu Lys Cys Ala Gln Asn Gln Asn Lys Thr 
        275                 280             


<210>  1274
<211>  45
<212>  PRT
<213>  Homo Sapiens

<400>  1274

Met Ser Asp Pro Ala Ala Phe Glu Ser Arg Leu Glu Lys Arg Ser Glu 
1               5                   10                  15      


Phe Arg Lys Gln Pro Val Gly His Ser Arg Gln Gly Asp Phe Ile Lys 
            20                  25                  30          


Cys Val Glu Gln Lys Asp Gly Ala Gln Asn Lys Leu Val 
        35                  40                  45  


<210>  1275
<211>  240
<212>  PRT
<213>  Homo Sapiens

<400>  1275

Met Ser Asp Pro Ala Ala Phe Glu Ser Arg Leu Glu Lys Arg Ser Glu 
1               5                   10                  15      


Phe Arg Lys Gln Pro Val Gly His Ser Arg Gln Gly Asp Phe Ile Lys 
            20                  25                  30          


Cys Val Glu Gln Lys Thr Asp Ala Leu Gly Lys Gln Ser Val Asn Arg 
        35                  40                  45              


Gly Phe Thr Lys Asp Lys Thr Leu Ser Ser Ile Phe Asn Ile Glu Met 
    50                  55                  60                  


Val Lys Glu Lys Thr Ala Glu Glu Ile Lys Gln Ile Trp Gln Gln Tyr 
65                  70                  75                  80  


Phe Ala Ala Lys Asp Thr Val Tyr Ala Val Ile Pro Ala Glu Lys Phe 
                85                  90                  95      


Asp Leu Ile Trp Asn Arg Ala Gln Ser Cys Pro Thr Phe Leu Cys Ala 
            100                 105                 110         


Leu Pro Arg Arg Glu Gly Tyr Glu Phe Phe Val Gly Gln Trp Thr Gly 
        115                 120                 125             


Thr Glu Leu His Phe Thr Ala Leu Ile Asn Ile Gln Thr Arg Gly Glu 
    130                 135                 140                 


Ala Ala Ala Ser Gln Leu Ile Leu Tyr His Tyr Pro Glu Leu Lys Glu 
145                 150                 155                 160 


Glu Lys Gly Ile Val Leu Met Thr Ala Glu Met Asp Ser Thr Phe Leu 
                165                 170                 175     


Asn Val Ala Glu Ala Gln Cys Ile Ala Asn Gln Val Gln Leu Phe Tyr 
            180                 185                 190         


Ala Thr Asp Arg Lys Glu Thr Tyr Gly Leu Val Glu Thr Phe Asn Leu 
        195                 200                 205             


Arg Pro Asn Glu Phe Lys Tyr Met Ser Val Ile Ala Glu Leu Glu Gln 
    210                 215                 220                 


Ser Gly Leu Gly Ala Glu Leu Lys Cys Ala Gln Asn Gln Asn Lys Thr 
225                 230                 235                 240 


<210>  1276
<211>  177
<212>  PRT
<213>  Homo Sapiens

<400>  1276

Met Val Lys Glu Lys Thr Ala Glu Glu Ile Lys Gln Ile Trp Gln Gln 
1               5                   10                  15      


Tyr Phe Ala Ala Lys Asp Thr Val Tyr Ala Val Ile Pro Ala Glu Lys 
            20                  25                  30          


Phe Asp Leu Ile Trp Asn Arg Ala Gln Ser Cys Pro Thr Phe Leu Cys 
        35                  40                  45              


Ala Leu Pro Arg Arg Glu Gly Tyr Glu Phe Phe Val Gly Gln Trp Thr 
    50                  55                  60                  


Gly Thr Glu Leu His Phe Thr Ala Leu Ile Asn Ile Gln Thr Arg Gly 
65                  70                  75                  80  


Glu Ala Ala Ala Ser Gln Leu Ile Leu Tyr His Tyr Pro Glu Leu Lys 
                85                  90                  95      


Glu Glu Lys Gly Ile Val Leu Met Thr Ala Glu Met Asp Ser Thr Phe 
            100                 105                 110         


Leu Asn Val Ala Glu Ala Gln Cys Ile Ala Asn Gln Val Gln Leu Phe 
        115                 120                 125             


Tyr Ala Thr Asp Arg Lys Glu Thr Tyr Gly Leu Val Glu Thr Phe Asn 
    130                 135                 140                 


Leu Arg Pro Asn Glu Phe Lys Tyr Met Ser Val Ile Ala Glu Leu Glu 
145                 150                 155                 160 


Gln Ser Gly Leu Gly Ala Glu Leu Lys Cys Ala Gln Asn Gln Asn Lys 
                165                 170                 175     


Thr 
    


<210>  1277
<211>  183
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1277

Xaa Gly Lys Gln Ser Val Asn Arg Gly Phe Thr Lys Asp Lys Thr Leu 
1               5                   10                  15      


Ser Ser Ile Phe Asn Ile Glu Met Val Lys Glu Lys Thr Ala Glu Glu 
            20                  25                  30          


Ile Lys Gln Ala Glu Lys Phe Asp Leu Ile Trp Asn Arg Ala Gln Ser 
        35                  40                  45              


Cys Pro Thr Phe Leu Cys Ala Leu Pro Arg Arg Glu Gly Tyr Glu Phe 
    50                  55                  60                  


Phe Val Gly Gln Trp Thr Gly Thr Glu Leu His Phe Thr Ala Leu Ile 
65                  70                  75                  80  


Asn Ile Gln Thr Arg Gly Glu Ala Ala Ala Ser Gln Leu Ile Leu Tyr 
                85                  90                  95      


His Tyr Pro Glu Leu Lys Glu Glu Lys Gly Ile Val Leu Met Thr Ala 
            100                 105                 110         


Glu Met Asp Ser Thr Phe Leu Asn Val Ala Glu Ala Gln Cys Ile Ala 
        115                 120                 125             


Asn Gln Val Gln Leu Phe Tyr Ala Thr Asp Arg Lys Glu Thr Tyr Gly 
    130                 135                 140                 


Leu Val Glu Thr Phe Asn Leu Arg Pro Asn Glu Phe Lys Tyr Met Ser 
145                 150                 155                 160 


Val Ile Ala Glu Leu Glu Gln Ser Gly Leu Gly Ala Glu Leu Lys Cys 
                165                 170                 175     


Ala Gln Asn Gln Asn Lys Thr 
            180             


<210>  1278
<211>  86
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1278

Xaa Val Arg Pro Gly Ser Gly Arg Pro Glu Gly Gly Ala Asp Ser Ser 
1               5                   10                  15      


Gly Val Gly Ala Glu Ala Glu Leu Gln Ala Asn Pro Phe Tyr Asp Arg 
            20                  25                  30          


Tyr Arg Asp Lys Ile Gln Leu Leu Arg Arg Ser Asp Pro Ala Ala Phe 
        35                  40                  45              


Glu Ser Arg Leu Glu Lys Arg Ser Glu Phe Arg Lys Gln Pro Val Gly 
    50                  55                  60                  


His Ser Arg Gln Gly Asp Phe Ile Lys Cys Val Glu Gln Lys Asp Gly 
65                  70                  75                  80  


Ala Gln Asn Lys Leu Val 
                85      


<210>  1279
<211>  310
<212>  PRT
<213>  Homo Sapiens

<400>  1279

Met Ala Ala Ala Val Ala Ala Ala Pro Gly Ala Leu Gly Ser Leu His 
1               5                   10                  15      


Ala Gly Gly Ala Arg Leu Val Ala Ala Cys Ser Ala Trp Leu Cys Pro 
            20                  25                  30          


Gly Leu Arg Leu Pro Gly Ser Leu Ala Gly Arg Arg Ala Gly Pro Ala 
        35                  40                  45              


Ile Trp Ala Gln Gly Trp Val Pro Ala Ala Gly Gly Pro Ala Pro Lys 
    50                  55                  60                  


Arg Gly Tyr Ser Ser Glu Met Lys Thr Glu Asp Glu Leu Arg Val Arg 
65                  70                  75                  80  


His Leu Glu Glu Glu Asn Arg Gly Ile Val Val Leu Gly Ile Asn Arg 
                85                  90                  95      


Ala Tyr Gly Lys Asn Ser Leu Ser Lys Asn Leu Ile Lys Met Leu Ser 
            100                 105                 110         


Lys Ala Val Asp Ala Leu Lys Ser Asp Lys Lys Val Arg Thr Ile Ile 
        115                 120                 125             


Ile Arg Ser Glu Val Pro Gly Ile Phe Cys Ala Ala Asn Leu Pro Val 
    130                 135                 140                 


Pro Thr Ile Ala Ala Ile Asp Gly Leu Ala Leu Gly Gly Gly Leu Glu 
145                 150                 155                 160 


Leu Ala Leu Ala Cys Asp Ile Arg Val Ala Ala Ser Ser Ala Lys Met 
                165                 170                 175     


Gly Leu Val Glu Thr Lys Leu Ala Ile Ile Pro Gly Gly Gly Gly Thr 
            180                 185                 190         


Gln Arg Leu Pro Arg Ala Ile Gly Met Ser Leu Ala Lys Glu Leu Ile 
        195                 200                 205             


Phe Ser Ala Arg Val Leu Asp Gly Lys Glu Ala Lys Ala Val Gly Leu 
    210                 215                 220                 


Ile Ser His Val Leu Glu Gln Asn Gln Glu Gly Asp Ala Ala Tyr Arg 
225                 230                 235                 240 


Lys Ala Leu Asp Leu Ala Arg Glu Phe Leu Pro Gln Gly Pro Val Ala 
                245                 250                 255     


Met Arg Val Ala Lys Leu Ala Ile Asn Gln Gly Met Glu Val Asp Leu 
            260                 265                 270         


Val Thr Gly Leu Ala Ile Glu Glu Ala Cys Tyr Ala Gln Thr Ile Pro 
        275                 280                 285             


Thr Lys Asp Arg Leu Glu Gly Leu Leu Ala Phe Lys Glu Lys Arg Pro 
    290                 295                 300                 


Pro Arg Tyr Lys Gly Glu 
305                 310 


<210>  1280
<211>  339
<212>  PRT
<213>  Homo Sapiens

<400>  1280

Met Ala Ala Ala Val Ala Ala Ala Pro Gly Ala Leu Gly Ser Leu His 
1               5                   10                  15      


Ala Gly Gly Ala Arg Leu Val Ala Ala Cys Ser Ala Trp Leu Cys Pro 
            20                  25                  30          


Gly Leu Arg Leu Pro Gly Ser Leu Ala Gly Arg Arg Ala Gly Pro Ala 
        35                  40                  45              


Ile Trp Ala Gln Gly Trp Val Pro Ala Ala Gly Gly Pro Ala Pro Lys 
    50                  55                  60                  


Arg Gly Tyr Ser Ser Glu Met Lys Thr Glu Asp Glu Leu Arg Val Arg 
65                  70                  75                  80  


His Leu Glu Glu Glu Asn Arg Gly Ile Val Val Leu Gly Ile Asn Arg 
                85                  90                  95      


Ala Tyr Gly Lys Asn Ser Leu Ser Lys Asn Leu Ile Lys Met Leu Ser 
            100                 105                 110         


Lys Ala Val Asp Ala Leu Lys Ser Asp Lys Lys Val Arg Thr Ile Ile 
        115                 120                 125             


Ile Arg Ser Glu Val Pro Gly Ile Phe Cys Ala Gly Ala Asp Leu Lys 
    130                 135                 140                 


Glu Arg Ala Lys Met Ser Ser Ser Glu Val Gly Pro Phe Val Ser Lys 
145                 150                 155                 160 


Ile Arg Ala Val Ile Asn Asp Ile Ala Asn Leu Pro Val Pro Thr Ile 
                165                 170                 175     


Ala Ala Ile Asp Gly Leu Ala Leu Gly Gly Gly Leu Glu Leu Ala Leu 
            180                 185                 190         


Ala Cys Asp Ile Arg Val Ala Ala Ser Ser Ala Lys Met Gly Leu Val 
        195                 200                 205             


Glu Thr Lys Leu Ala Ile Ile Pro Gly Gly Gly Gly Thr Gln Arg Leu 
    210                 215                 220                 


Pro Arg Ala Ile Gly Met Ser Leu Ala Lys Glu Leu Ile Phe Ser Ala 
225                 230                 235                 240 


Arg Val Leu Asp Gly Lys Glu Ala Lys Ala Val Gly Leu Ile Ser His 
                245                 250                 255     


Val Leu Glu Gln Asn Gln Glu Gly Asp Ala Ala Tyr Arg Lys Ala Leu 
            260                 265                 270         


Asp Leu Ala Arg Glu Phe Leu Pro Gln Gly Pro Val Ala Met Arg Val 
        275                 280                 285             


Ala Lys Leu Ala Ile Asn Gln Gly Met Glu Val Asp Leu Val Thr Gly 
    290                 295                 300                 


Leu Ala Ile Glu Glu Ala Cys Tyr Ala Gln Thr Ile Pro Thr Lys Asp 
305                 310                 315                 320 


Arg Leu Glu Gly Leu Leu Ala Phe Lys Glu Lys Arg Pro Pro Arg Tyr 
                325                 330                 335     


Lys Gly Glu 
            


<210>  1281
<211>  164
<212>  PRT
<213>  Homo Sapiens

<400>  1281

Met Pro Asp Thr Met Leu Pro Ala Cys Phe Leu Gly Leu Leu Ala Phe 
1               5                   10                  15      


Ser Ser Ala Cys Tyr Phe Gln Asn Cys Pro Arg Gly Gly Lys Arg Ala 
            20                  25                  30          


Met Ser Asp Leu Glu Leu Arg Gln Cys Leu Pro Cys Gly Pro Gly Gly 
        35                  40                  45              


Lys Gly Arg Cys Phe Gly Pro Ser Ile Cys Cys Ala Asp Glu Leu Gly 
    50                  55                  60                  


Cys Phe Val Gly Thr Ala Glu Ala Leu Arg Cys Gln Glu Glu Asn Tyr 
65                  70                  75                  80  


Leu Pro Ser Pro Cys Gln Ser Gly Gln Lys Ala Cys Gly Ser Gly Gly 
                85                  90                  95      


Arg Cys Ala Ala Phe Gly Val Cys Cys Asn Asp Glu Ser Cys Val Thr 
            100                 105                 110         


Glu Pro Glu Cys Arg Glu Gly Phe His Arg Arg Ala Arg Ala Ser Asp 
        115                 120                 125             


Arg Ser Asn Ala Thr Gln Leu Asp Gly Pro Ala Gly Ala Leu Leu Leu 
    130                 135                 140                 


Arg Leu Val Gln Leu Ala Gly Ala Pro Glu Pro Phe Glu Pro Ala Gln 
145                 150                 155                 160 


Pro Asp Ala Tyr 
                


<210>  1282
<211>  151
<212>  PRT
<213>  Homo Sapiens

<400>  1282

Met Ser Ser Ala Met Leu Val Thr Cys Leu Pro Asp Pro Ser Ser Ser 
1               5                   10                  15      


Phe Arg Glu Asp Ala Pro Arg Pro Pro Val Pro Gly Glu Glu Gly Glu 
            20                  25                  30          


Thr Pro Pro Cys Gln Pro Gly Val Gly Lys Gly Gln Val Thr Lys Pro 
        35                  40                  45              


Met Pro Val Ser Ser Asn Thr Arg Arg Asn Glu Asp Gly Leu Gly Glu 
    50                  55                  60                  


Pro Glu Gly Arg Ala Ser Pro Asp Ser Pro Leu Thr Arg Trp Thr Lys 
65                  70                  75                  80  


Ser Leu His Ser Leu Leu Gly Asp Gln Asp Gly Ala Tyr Leu Phe Arg 
                85                  90                  95      


Thr Phe Leu Glu Arg Glu Lys Cys Val Asp Thr Leu Asp Phe Trp Phe 
            100                 105                 110         


Ala Cys Asn Gly Phe Arg Gln Met Asn Leu Lys Asp Thr Lys Thr Leu 
        115                 120                 125             


Arg Val Ala Lys Ala Ile Tyr Lys Arg Tyr Ile Glu Asn Asn Ser Ile 
    130                 135                 140                 


Val Ser Lys Gln Leu Lys Pro 
145                 150     


<210>  1283
<211>  192
<212>  PRT
<213>  Homo Sapiens

<400>  1283

Met Ser Ser Ala Met Leu Val Thr Cys Leu Pro Asp Pro Ser Ser Ser 
1               5                   10                  15      


Phe Arg Glu Asp Ala Pro Arg Pro Pro Val Pro Gly Glu Glu Gly Glu 
            20                  25                  30          


Thr Pro Pro Cys Gln Pro Gly Val Gly Lys Gly Gln Val Thr Lys Pro 
        35                  40                  45              


Met Pro Val Ser Ser Asn Thr Arg Arg Asn Glu Asp Gly Leu Gly Glu 
    50                  55                  60                  


Pro Glu Gly Arg Ala Ser Pro Asp Ser Pro Leu Thr Arg Trp Thr Lys 
65                  70                  75                  80  


Ser Leu His Ser Leu Leu Gly Asp Gln Asp Gly Ala Tyr Leu Phe Arg 
                85                  90                  95      


Thr Phe Leu Glu Arg Glu Lys Cys Val Asp Thr Leu Asp Phe Trp Phe 
            100                 105                 110         


Ala Cys Asn Gly Phe Arg Gln Met Asn Leu Lys Asp Thr Lys Thr Leu 
        115                 120                 125             


Arg Val Ala Lys Ala Ile Tyr Lys Arg Tyr Ile Glu Asn Asn Ser Ile 
    130                 135                 140                 


Val Ser Lys Gln Leu Lys Pro Ala Thr Lys Thr Tyr Ile Arg Asp Gly 
145                 150                 155                 160 


Ile Lys Lys Gln Gln Ile Asp Ser Ile Met Phe Asp Gln Ala Gln Thr 
                165                 170                 175     


Glu Ile Gln Ser Val Met Glu Glu Asn Ala Tyr Gln Met Phe Leu Thr 
            180                 185                 190         


<210>  1284
<211>  192
<212>  PRT
<213>  Homo Sapiens

<400>  1284

Met Ser Ser Ala Met Leu Val Thr Cys Leu Pro Asp Pro Ser Ser Ser 
1               5                   10                  15      


Phe Arg Glu Asp Ala Pro Arg Pro Pro Val Pro Gly Glu Glu Gly Glu 
            20                  25                  30          


Thr Pro Pro Cys Gln Pro Gly Val Gly Lys Gly Gln Val Thr Lys Pro 
        35                  40                  45              


Met Pro Val Ser Ser Asn Thr Arg Arg Asn Glu Asp Gly Leu Gly Glu 
    50                  55                  60                  


Pro Glu Gly Arg Ala Ser Pro Asp Ser Pro Leu Thr Arg Trp Thr Lys 
65                  70                  75                  80  


Ser Leu His Ser Leu Leu Gly Asp Gln Asp Gly Ala Tyr Leu Phe Arg 
                85                  90                  95      


Thr Phe Leu Glu Arg Glu Lys Cys Val Asp Thr Leu Asp Phe Trp Phe 
            100                 105                 110         


Ala Cys Asn Gly Phe Arg Gln Met Asn Leu Lys Asp Thr Lys Thr Leu 
        115                 120                 125             


Arg Val Ala Lys Ala Ile Tyr Lys Arg Tyr Ile Glu Asn Asn Ser Ile 
    130                 135                 140                 


Val Ser Lys Gln Leu Lys Pro Ala Thr Lys Thr Tyr Ile Arg Asp Gly 
145                 150                 155                 160 


Ile Lys Lys Gln Gln Ile Asp Ser Ile Met Phe Asp Gln Ala Gln Thr 
                165                 170                 175     


Glu Ile Gln Ser Val Met Glu Glu Asn Ala Tyr Gln Met Phe Leu Thr 
            180                 185                 190         


<210>  1285
<211>  843
<212>  PRT
<213>  Homo Sapiens

<400>  1285

Met Ser Ser Ala Met Leu Val Thr Cys Leu Pro Asp Pro Ser Ser Ser 
1               5                   10                  15      


Phe Arg Glu Asp Ala Pro Arg Pro Pro Val Pro Gly Glu Glu Gly Glu 
            20                  25                  30          


Thr Pro Pro Cys Gln Pro Gly Val Gly Lys Gly Gln Val Thr Lys Pro 
        35                  40                  45              


Met Pro Val Ser Ser Asn Thr Arg Arg Asn Glu Asp Gly Leu Gly Glu 
    50                  55                  60                  


Pro Glu Gly Arg Ala Ser Pro Asp Ser Pro Leu Thr Arg Trp Thr Lys 
65                  70                  75                  80  


Ser Leu His Ser Leu Leu Gly Asp Gln Asp Gly Ala Tyr Leu Phe Arg 
                85                  90                  95      


Thr Phe Leu Glu Arg Glu Lys Cys Val Asp Thr Leu Asp Phe Trp Phe 
            100                 105                 110         


Ala Cys Asn Gly Phe Arg Gln Met Asn Leu Lys Asp Thr Lys Thr Leu 
        115                 120                 125             


Arg Val Ala Lys Ala Ile Tyr Lys Arg Tyr Ile Glu Asn Asn Ser Ile 
    130                 135                 140                 


Val Ser Lys Gln Leu Lys Pro Ala Thr Lys Thr Tyr Ile Arg Asp Gly 
145                 150                 155                 160 


Ile Lys Lys Gln Gln Ile Asp Ser Ile Met Phe Asp Gln Ala Gln Thr 
                165                 170                 175     


Glu Ile Gln Ser Val Met Glu Glu Asn Ala Tyr Gln Met Phe Leu Thr 
            180                 185                 190         


Ser Asp Ile Tyr Leu Glu Tyr Val Arg Ser Gly Gly Glu Asn Thr Ala 
        195                 200                 205             


Tyr Met Ser Asn Gly Gly Leu Gly Ser Leu Lys Val Val Cys Gly Tyr 
    210                 215                 220                 


Leu Pro Thr Leu Asn Glu Glu Glu Glu Trp Thr Cys Ala Asp Phe Lys 
225                 230                 235                 240 


Cys Lys Leu Ser Pro Thr Val Val Gly Leu Ser Ser Lys Thr Leu Arg 
                245                 250                 255     


Ala Thr Ala Ser Val Arg Ser Thr Glu Thr Val Asp Ser Gly Tyr Arg 
            260                 265                 270         


Ser Phe Lys Arg Ser Asp Pro Val Asn Pro Tyr His Ile Gly Ser Gly 
        275                 280                 285             


Tyr Val Phe Ala Pro Ala Thr Ser Ala Asn Asp Ser Glu Ile Ser Ser 
    290                 295                 300                 


Asp Ala Leu Thr Asp Asp Ser Met Ser Met Thr Asp Ser Ser Val Asp 
305                 310                 315                 320 


Gly Ile Pro Pro Tyr Arg Val Gly Ser Lys Lys Gln Leu Gln Arg Glu 
                325                 330                 335     


Met His Arg Ser Val Lys Ala Asn Gly Gln Val Ser Leu Pro His Phe 
            340                 345                 350         


Pro Arg Thr His Arg Leu Pro Lys Glu Met Thr Pro Val Glu Pro Ala 
        355                 360                 365             


Thr Phe Ala Ala Glu Leu Ile Ser Arg Leu Glu Lys Leu Lys Leu Glu 
    370                 375                 380                 


Leu Glu Ser Arg His Ser Leu Glu Glu Arg Leu Gln Gln Ile Arg Glu 
385                 390                 395                 400 


Asp Glu Glu Arg Glu Gly Ser Glu Leu Thr Leu Asn Ser Arg Glu Gly 
                405                 410                 415     


Ala Pro Thr Gln His Pro Leu Ser Leu Leu Pro Ser Gly Ser Tyr Glu 
            420                 425                 430         


Glu Asp Pro Gln Thr Ile Leu Asp Asp His Leu Ser Arg Val Leu Lys 
        435                 440                 445             


Thr Pro Gly Cys Gln Ser Pro Gly Val Gly Arg Tyr Ser Pro Arg Ser 
    450                 455                 460                 


Arg Ser Pro Asp His His His His His His Ser Gln Tyr His Ser Leu 
465                 470                 475                 480 


Leu Pro Pro Gly Gly Lys Leu Pro Pro Ala Ala Ala Ser Pro Gly Ala 
                485                 490                 495     


Cys Pro Leu Leu Gly Gly Lys Gly Phe Val Thr Lys Gln Thr Thr Lys 
            500                 505                 510         


His Val His His His Tyr Ile His His His Ala Val Pro Lys Thr Lys 
        515                 520                 525             


Glu Glu Ile Glu Ala Glu Ala Thr Gln Arg Val His Cys Phe Cys Pro 
    530                 535                 540                 


Gly Gly Ser Glu Tyr Tyr Cys Tyr Ser Lys Cys Lys Ser His Ser Lys 
545                 550                 555                 560 


Ala Pro Glu Thr Met Pro Ser Glu Gln Phe Gly Gly Ser Arg Gly Ser 
                565                 570                 575     


Thr Leu Pro Lys Arg Asn Gly Lys Gly Thr Glu Pro Gly Leu Ala Leu 
            580                 585                 590         


Pro Ala Arg Glu Gly Gly Ala Pro Gly Gly Ala Gly Ala Leu Gln Leu 
        595                 600                 605             


Pro Arg Glu Glu Gly Asp Arg Ser Gln Asp Val Trp Gln Trp Met Leu 
    610                 615                 620                 


Glu Ser Glu Arg Gln Ser Lys Pro Lys Pro His Ser Ala Gln Ser Thr 
625                 630                 635                 640 


Lys Lys Ala Tyr Pro Leu Glu Ser Ala Arg Ser Ser Pro Gly Glu Arg 
                645                 650                 655     


Ala Ser Arg His His Leu Trp Gly Gly Asn Ser Gly His Pro Arg Thr 
            660                 665                 670         


Thr Pro Arg Ala His Leu Phe Thr Gln Asp Pro Ala Met Pro Pro Leu 
        675                 680                 685             


Thr Pro Pro Asn Thr Leu Ala Gln Leu Glu Glu Ala Cys Arg Arg Leu 
    690                 695                 700                 


Ala Glu Val Ser Lys Pro Pro Lys Gln Arg Cys Cys Val Ala Ser Gln 
705                 710                 715                 720 


Gln Arg Asp Arg Asn His Ser Ala Thr Val Gln Thr Gly Ala Thr Pro 
                725                 730                 735     


Phe Ser Asn Pro Ser Leu Ala Pro Glu Asp His Lys Glu Pro Lys Lys 
            740                 745                 750         


Leu Ala Gly Val His Ala Leu Gln Ala Ser Glu Leu Val Val Thr Tyr 
        755                 760                 765             


Phe Phe Cys Gly Glu Glu Ile Pro Tyr Arg Arg Met Leu Lys Ala Gln 
    770                 775                 780                 


Ser Leu Thr Leu Gly His Phe Lys Glu Gln Leu Ser Lys Lys Gly Asn 
785                 790                 795                 800 


Tyr Arg Tyr Tyr Phe Lys Lys Ala Ser Asp Glu Phe Ala Cys Gly Ala 
                805                 810                 815     


Val Phe Glu Glu Ile Trp Glu Asp Glu Thr Val Leu Pro Met Tyr Glu 
            820                 825                 830         


Gly Arg Ile Leu Gly Lys Val Glu Arg Ile Asp 
        835                 840             


<210>  1286
<211>  778
<212>  PRT
<213>  Homo Sapiens

<400>  1286

Met Ser Ser Ala Met Leu Val Thr Cys Leu Pro Asp Pro Ser Ser Ser 
1               5                   10                  15      


Phe Arg Glu Asp Ala Pro Arg Pro Pro Val Pro Gly Glu Glu Gly Glu 
            20                  25                  30          


Thr Pro Pro Cys Gln Pro Gly Val Gly Lys Gly Gln Val Thr Lys Pro 
        35                  40                  45              


Met Pro Val Ser Ser Asn Thr Arg Arg Asn Glu Asp Gly Leu Gly Glu 
    50                  55                  60                  


Pro Glu Gly Arg Ala Ser Pro Asp Ser Pro Leu Thr Arg Trp Thr Lys 
65                  70                  75                  80  


Ser Leu His Ser Leu Leu Gly Asp Gln Asp Gly Ala Tyr Leu Phe Arg 
                85                  90                  95      


Thr Phe Leu Glu Arg Glu Lys Cys Val Asp Thr Leu Asp Phe Trp Phe 
            100                 105                 110         


Ala Cys Asn Gly Phe Arg Gln Met Asn Leu Lys Asp Thr Lys Thr Leu 
        115                 120                 125             


Arg Val Ala Lys Ala Ile Tyr Lys Arg Tyr Ile Glu Asn Asn Ser Ile 
    130                 135                 140                 


Val Ser Lys Gln Leu Lys Pro Ala Thr Lys Thr Tyr Ile Arg Asp Gly 
145                 150                 155                 160 


Ile Lys Lys Gln Gln Ile Asp Ser Ile Met Phe Asp Gln Ala Gln Thr 
                165                 170                 175     


Glu Ile Gln Ser Val Met Glu Glu Asn Ala Tyr Gln Met Phe Leu Thr 
            180                 185                 190         


Ser Asp Ile Tyr Leu Glu Tyr Val Arg Ser Gly Gly Glu Asn Thr Ala 
        195                 200                 205             


Tyr Met Ser Asn Gly Gly Leu Gly Ser Leu Lys Val Val Cys Gly Tyr 
    210                 215                 220                 


Leu Pro Thr Leu Asn Glu Glu Glu Glu Trp Thr Cys Ala Asp Phe Lys 
225                 230                 235                 240 


Cys Lys Leu Ser Pro Thr Val Val Gly Leu Ser Ser Lys Thr Leu Arg 
                245                 250                 255     


Ala Thr Ala Ser Val Arg Ser Thr Glu Thr Val Asp Ser Gly Tyr Arg 
            260                 265                 270         


Ser Phe Lys Arg Ser Asp Pro Val Asn Pro Tyr His Ile Gly Ser Gly 
        275                 280                 285             


Tyr Val Phe Ala Pro Ala Thr Ser Ala Asn Asp Ser Glu Ile Ser Ser 
    290                 295                 300                 


Asp Ala Leu Thr Asp Asp Ser Met Ser Met Thr Asp Ser Ser Val Asp 
305                 310                 315                 320 


Gly Ile Pro Pro Tyr Arg Val Gly Ser Lys Lys Gln Leu Gln Arg Glu 
                325                 330                 335     


Met His Arg Ser Val Lys Ala Asn Gly Gln Val Ser Leu Pro His Phe 
            340                 345                 350         


Pro Arg Thr His Arg Leu Pro Lys Glu Met Thr Pro Val Glu Pro Ala 
        355                 360                 365             


Thr Phe Ala Ala Glu Leu Ile Ser Arg Leu Glu Lys Leu Lys Leu Glu 
    370                 375                 380                 


Leu Glu Ser Arg His Ser Leu Glu Glu Arg Leu Gln Gln Ile Arg Glu 
385                 390                 395                 400 


Asp Glu Glu Arg Glu Gly Ser Glu Leu Thr Leu Asn Ser Arg Glu Gly 
                405                 410                 415     


Ala Pro Thr Gln His Pro Leu Ser Leu Leu Pro Ser Gly Ser Tyr Glu 
            420                 425                 430         


Glu Asp Pro Gln Thr Ile Leu Asp Asp His Leu Ser Arg Val Leu Lys 
        435                 440                 445             


Thr Pro Gly Cys Gln Ser Pro Gly Val Gly Arg Tyr Ser Pro Arg Ser 
    450                 455                 460                 


Arg Ser Pro Asp His His His His His His Ser Gln Tyr His Ser Leu 
465                 470                 475                 480 


Leu Pro Pro Gly Gly Lys Leu Pro Pro Ala Ala Ala Ser Pro Gly Ala 
                485                 490                 495     


Cys Pro Leu Leu Gly Gly Lys Gly Phe Val Thr Lys Gln Thr Thr Lys 
            500                 505                 510         


His Val His His His Tyr Ile His His His Ala Val Pro Lys Thr Lys 
        515                 520                 525             


Glu Glu Ile Glu Ala Glu Ala Thr Gln Arg Val His Cys Phe Cys Pro 
    530                 535                 540                 


Gly Gly Ser Glu Tyr Tyr Cys Tyr Ser Lys Cys Lys Ser His Ser Lys 
545                 550                 555                 560 


Ala Pro Glu Thr Met Pro Ser Glu Gln Phe Gly Ala Gln Ser Thr Lys 
                565                 570                 575     


Lys Ala Tyr Pro Leu Glu Ser Ala Arg Ser Ser Pro Gly Glu Arg Ala 
            580                 585                 590         


Ser Arg His His Leu Trp Gly Gly Asn Ser Gly His Pro Arg Thr Thr 
        595                 600                 605             


Pro Arg Ala His Leu Phe Thr Gln Asp Pro Ala Met Pro Pro Leu Thr 
    610                 615                 620                 


Pro Pro Asn Thr Leu Ala Gln Leu Glu Glu Ala Cys Arg Arg Leu Ala 
625                 630                 635                 640 


Glu Val Ser Lys Pro Pro Lys Gln Arg Cys Cys Val Ala Ser Gln Gln 
                645                 650                 655     


Arg Asp Arg Asn His Ser Ala Thr Val Gln Thr Gly Ala Thr Pro Phe 
            660                 665                 670         


Ser Asn Pro Ser Leu Ala Pro Glu Asp His Lys Glu Pro Lys Lys Leu 
        675                 680                 685             


Ala Gly Val His Ala Leu Gln Ala Ser Glu Leu Val Val Thr Tyr Phe 
    690                 695                 700                 


Phe Cys Gly Glu Glu Ile Pro Tyr Arg Arg Met Leu Lys Ala Gln Ser 
705                 710                 715                 720 


Leu Thr Leu Gly His Phe Lys Glu Gln Leu Ser Lys Lys Gly Asn Tyr 
                725                 730                 735     


Arg Tyr Tyr Phe Lys Lys Ala Ser Asp Glu Phe Ala Cys Gly Ala Val 
            740                 745                 750         


Phe Glu Glu Ile Trp Glu Asp Glu Thr Val Leu Pro Met Tyr Glu Gly 
        755                 760                 765             


Arg Ile Leu Gly Lys Val Glu Arg Ile Asp 
    770                 775             


<210>  1287
<211>  271
<212>  PRT
<213>  Homo Sapiens

<400>  1287

Met Ser Ser Ala Met Leu Val Thr Cys Leu Pro Asp Pro Ser Ser Ser 
1               5                   10                  15      


Phe Arg Glu Asp Ala Pro Arg Pro Pro Val Pro Gly Glu Glu Gly Glu 
            20                  25                  30          


Thr Pro Pro Cys Gln Pro Gly Val Gly Lys Gly Gln Val Thr Lys Pro 
        35                  40                  45              


Met Pro Val Ser Ser Asn Thr Arg Arg Asn Glu Asp Gly Leu Gly Glu 
    50                  55                  60                  


Pro Glu Gly Arg Ala Ser Pro Asp Ser Pro Leu Thr Arg Trp Thr Lys 
65                  70                  75                  80  


Ser Leu His Ser Leu Leu Gly Asp Gln Asp Gly Ala Tyr Leu Phe Arg 
                85                  90                  95      


Thr Phe Leu Glu Arg Glu Lys Cys Val Asp Thr Leu Asp Phe Trp Phe 
            100                 105                 110         


Ala Cys Asn Gly Phe Arg Gln Met Asn Leu Lys Asp Thr Lys Thr Leu 
        115                 120                 125             


Arg Val Ala Lys Ala Ile Tyr Lys Arg Tyr Ile Glu Asn Asn Ser Ile 
    130                 135                 140                 


Val Ser Lys Gln Leu Lys Pro Ala Thr Lys Thr Tyr Ile Arg Asp Gly 
145                 150                 155                 160 


Ile Lys Lys Gln Gln Ile Asp Ser Ile Met Phe Asp Gln Ala Gln Thr 
                165                 170                 175     


Glu Ile Gln Ser Val Met Glu Glu Asn Ala Tyr Gln Met Phe Leu Thr 
            180                 185                 190         


Ser Asp Ile Tyr Leu Glu Tyr Val Arg Ser Gly Gly Glu Asn Thr Ala 
        195                 200                 205             


Tyr Met Ser Asn Gly Gly Leu Gly Ser Leu Lys Val Val Cys Gly Tyr 
    210                 215                 220                 


Leu Pro Thr Leu Asn Glu Glu Glu Glu Trp Thr Cys Ala Asp Phe Lys 
225                 230                 235                 240 


Cys Lys Leu Ser Pro Thr Val Val Gly Leu Ser Ser Lys Thr Leu Arg 
                245                 250                 255     


Ala Thr Ala Ser Val Arg Ser Thr Glu Thr Val Asp Ser Gly Tyr 
            260                 265                 270     


<210>  1288
<211>  778
<212>  PRT
<213>  Homo Sapiens

<400>  1288

Met Ser Ser Ala Met Leu Val Thr Cys Leu Pro Asp Pro Ser Ser Ser 
1               5                   10                  15      


Phe Arg Glu Asp Ala Pro Arg Pro Pro Val Pro Gly Glu Glu Gly Glu 
            20                  25                  30          


Thr Pro Pro Cys Gln Pro Gly Val Gly Lys Gly Gln Val Thr Lys Pro 
        35                  40                  45              


Met Pro Val Ser Ser Asn Thr Arg Arg Asn Glu Asp Gly Leu Gly Glu 
    50                  55                  60                  


Pro Glu Gly Arg Ala Ser Pro Asp Ser Pro Leu Thr Arg Trp Thr Lys 
65                  70                  75                  80  


Ser Leu His Ser Leu Leu Gly Asp Gln Asp Gly Ala Tyr Leu Phe Arg 
                85                  90                  95      


Thr Phe Leu Glu Arg Glu Lys Cys Val Asp Thr Leu Asp Phe Trp Phe 
            100                 105                 110         


Ala Cys Asn Gly Phe Arg Gln Met Asn Leu Lys Asp Thr Lys Thr Leu 
        115                 120                 125             


Arg Val Ala Lys Ala Ile Tyr Lys Arg Tyr Ile Glu Asn Asn Ser Ile 
    130                 135                 140                 


Val Ser Lys Gln Leu Lys Pro Ala Thr Lys Thr Tyr Ile Arg Asp Gly 
145                 150                 155                 160 


Ile Lys Lys Gln Gln Ile Asp Ser Ile Met Phe Asp Gln Ala Gln Thr 
                165                 170                 175     


Glu Ile Gln Ser Val Met Glu Glu Asn Ala Tyr Gln Met Phe Leu Thr 
            180                 185                 190         


Ser Asp Ile Tyr Leu Glu Tyr Val Arg Ser Gly Gly Glu Asn Thr Ala 
        195                 200                 205             


Tyr Met Ser Asn Gly Gly Leu Gly Ser Leu Lys Val Val Cys Gly Tyr 
    210                 215                 220                 


Leu Pro Thr Leu Asn Glu Glu Glu Glu Trp Thr Cys Ala Asp Phe Lys 
225                 230                 235                 240 


Cys Lys Leu Ser Pro Thr Val Val Gly Leu Ser Ser Lys Thr Leu Arg 
                245                 250                 255     


Ala Thr Ala Ser Val Arg Ser Thr Glu Thr Val Asp Ser Gly Tyr Arg 
            260                 265                 270         


Ser Phe Lys Arg Ser Asp Pro Val Asn Pro Tyr His Ile Gly Ser Gly 
        275                 280                 285             


Tyr Val Phe Ala Pro Ala Thr Ser Ala Asn Asp Ser Glu Ile Ser Ser 
    290                 295                 300                 


Asp Ala Leu Thr Asp Asp Ser Met Ser Met Thr Asp Ser Ser Val Asp 
305                 310                 315                 320 


Gly Ile Pro Pro Tyr Arg Val Gly Ser Lys Lys Gln Leu Gln Arg Glu 
                325                 330                 335     


Met His Arg Ser Val Lys Ala Asn Gly Gln Val Ser Leu Pro His Phe 
            340                 345                 350         


Pro Arg Thr His Arg Leu Pro Lys Glu Met Thr Pro Val Glu Pro Ala 
        355                 360                 365             


Thr Phe Ala Ala Glu Leu Ile Ser Arg Leu Glu Lys Leu Lys Leu Glu 
    370                 375                 380                 


Leu Glu Ser Arg His Ser Leu Glu Glu Arg Leu Gln Gln Ile Arg Glu 
385                 390                 395                 400 


Asp Glu Glu Arg Glu Gly Ser Glu Leu Thr Leu Asn Ser Arg Glu Gly 
                405                 410                 415     


Ala Pro Thr Gln His Pro Leu Ser Leu Leu Pro Ser Gly Ser Tyr Glu 
            420                 425                 430         


Glu Asp Pro Gln Thr Ile Leu Asp Asp His Leu Ser Arg Val Leu Lys 
        435                 440                 445             


Thr Pro Gly Cys Gln Ser Pro Gly Val Gly Arg Tyr Ser Pro Arg Ser 
    450                 455                 460                 


Arg Ser Pro Asp His His His His His His Ser Gln Tyr His Ser Leu 
465                 470                 475                 480 


Leu Pro Pro Gly Gly Lys Leu Pro Pro Ala Ala Ala Ser Pro Gly Ala 
                485                 490                 495     


Cys Pro Leu Leu Gly Gly Lys Gly Phe Val Thr Lys Gln Thr Thr Lys 
            500                 505                 510         


His Val His His His Tyr Ile His His His Ala Val Pro Lys Thr Lys 
        515                 520                 525             


Glu Glu Ile Glu Ala Glu Ala Thr Gln Arg Val His Cys Phe Cys Pro 
    530                 535                 540                 


Gly Gly Ser Glu Tyr Tyr Cys Tyr Ser Lys Cys Lys Ser His Ser Lys 
545                 550                 555                 560 


Ala Pro Glu Thr Met Pro Ser Glu Gln Phe Gly Ala Gln Ser Thr Lys 
                565                 570                 575     


Lys Ala Tyr Pro Leu Glu Ser Ala Arg Ser Ser Pro Gly Glu Arg Ala 
            580                 585                 590         


Ser Arg His His Leu Trp Gly Gly Asn Ser Gly His Pro Arg Thr Thr 
        595                 600                 605             


Pro Arg Ala His Leu Phe Thr Gln Asp Pro Ala Met Pro Pro Leu Thr 
    610                 615                 620                 


Pro Pro Asn Thr Leu Ala Gln Leu Glu Glu Ala Cys Arg Arg Leu Ala 
625                 630                 635                 640 


Glu Val Ser Lys Pro Pro Lys Gln Arg Cys Cys Val Ala Ser Gln Gln 
                645                 650                 655     


Arg Asp Arg Asn His Ser Ala Thr Val Gln Thr Gly Ala Thr Pro Phe 
            660                 665                 670         


Ser Asn Pro Ser Leu Ala Pro Glu Asp His Lys Glu Pro Lys Lys Leu 
        675                 680                 685             


Ala Gly Val His Ala Leu Gln Ala Ser Glu Leu Val Val Thr Tyr Phe 
    690                 695                 700                 


Phe Cys Gly Glu Glu Ile Pro Tyr Arg Arg Met Leu Lys Ala Gln Ser 
705                 710                 715                 720 


Leu Thr Leu Gly His Phe Lys Glu Gln Leu Ser Lys Lys Gly Asn Tyr 
                725                 730                 735     


Arg Tyr Tyr Phe Lys Lys Ala Ser Asp Glu Phe Ala Cys Gly Ala Val 
            740                 745                 750         


Phe Glu Glu Ile Trp Glu Asp Glu Thr Val Leu Pro Met Tyr Glu Gly 
        755                 760                 765             


Arg Ile Leu Gly Lys Val Glu Arg Ile Asp 
    770                 775             


<210>  1289
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  1289

Met Ser Ser Ala Met Leu Val Thr Cys Leu Pro Asp Pro Ser Ser Ser 
1               5                   10                  15      


Phe Arg Glu Asp Ala Pro Arg Pro Pro Val Pro Gly Glu Glu Gly Glu 
            20                  25                  30          


Thr Pro Pro Cys Gln Pro Gly Val Gly Lys Gly Gln Val Thr Lys Pro 
        35                  40                  45              


Met Pro Val Ser Ser Asn Thr Arg Arg Asn Glu Asp Gly Leu Gly Glu 
    50                  55                  60                  


Pro Glu Gly Arg Ala Ser Pro Asp Ser Pro Leu Thr Arg Trp Thr Lys 
65                  70                  75                  80  


Ser Leu His Ser Leu Leu Gly Asp Gln Asp Gly Ala Tyr Leu Phe Arg 
                85                  90                  95      


Thr Phe Leu Glu Arg Glu Lys Cys Val Asp Thr Leu Asp Phe Trp Phe 
            100                 105                 110         


Ala Cys Asn Gly Phe Arg Gln Met Asn Leu Lys Asp Thr Lys Thr Leu 
        115                 120                 125             


Arg Val Ala Lys Asp Phe Cys His Asp Ile Leu Phe Tyr Leu Tyr Cys 
    130                 135                 140                 


Lys Leu Cys Ile Ile Lys Ser Ser Phe Lys Glu Asn Tyr Leu Val Gln 
145                 150                 155                 160 


<210>  1290
<211>  227
<212>  PRT
<213>  Homo Sapiens

<400>  1290

Met Val Pro Val Leu Leu Ser Leu Leu Leu Leu Leu Gly Pro Ala Val 
1               5                   10                  15      


Pro Gln Glu Asn Gln Asp Gly Arg Tyr Ser Leu Thr Tyr Ile Tyr Thr 
            20                  25                  30          


Gly Leu Ser Lys His Val Glu Asp Val Pro Ala Phe Gln Ala Leu Gly 
        35                  40                  45              


Ser Leu Asn Asp Leu Gln Phe Phe Arg Tyr Asn Ser Lys Asp Arg Lys 
    50                  55                  60                  


Ser Gln Pro Met Gly Leu Trp Arg Gln Val Glu Gly Met Glu Asp Trp 
65                  70                  75                  80  


Lys Gln Asp Ser Gln Leu Gln Lys Ala Arg Glu Asp Ile Phe Met Glu 
                85                  90                  95      


Thr Leu Lys Asp Ile Val Glu Tyr Tyr Asn Asp Ser Asn Gly Ser His 
            100                 105                 110         


Val Leu Gln Gly Arg Phe Gly Cys Glu Ile Glu Asn Asn Arg Ser Ser 
        115                 120                 125             


Gly Ala Phe Trp Lys Tyr Tyr Tyr Asp Gly Lys Asp Tyr Ile Glu Phe 
    130                 135                 140                 


Asn Lys Glu Ile Pro Ala Trp Val Pro Phe Asp Pro Ala Ala Gln Ile 
145                 150                 155                 160 


Thr Lys Gln Lys Trp Glu Ala Glu Pro Val Tyr Val Gln Arg Ala Lys 
                165                 170                 175     


Ala Tyr Leu Glu Glu Glu Cys Pro Ala Thr Leu Arg Lys Tyr Leu Lys 
            180                 185                 190         


Tyr Ser Lys Asn Ile Leu Asp Arg Gln Gly Thr His Cys Phe Leu Leu 
        195                 200                 205             


Pro Ser Thr Glu Pro Arg Ile Lys Asp Asp Leu Arg Leu Gly Ala Gln 
    210                 215                 220                 


Ala Thr Ser 
225         


<210>  1291
<211>  298
<212>  PRT
<213>  Homo Sapiens

<400>  1291

Met Val Arg Met Val Pro Val Leu Leu Ser Leu Leu Leu Leu Leu Gly 
1               5                   10                  15      


Pro Ala Val Pro Gln Glu Asn Gln Asp Gly Arg Tyr Ser Leu Thr Tyr 
            20                  25                  30          


Ile Tyr Thr Gly Leu Ser Lys His Val Glu Asp Val Pro Ala Phe Gln 
        35                  40                  45              


Ala Leu Gly Ser Leu Asn Asp Leu Gln Phe Phe Arg Tyr Asn Ser Lys 
    50                  55                  60                  


Asp Arg Lys Ser Gln Pro Met Gly Leu Trp Arg Gln Val Glu Gly Met 
65                  70                  75                  80  


Glu Asp Trp Lys Gln Asp Ser Gln Leu Gln Lys Ala Arg Glu Asp Ile 
                85                  90                  95      


Phe Met Glu Thr Leu Lys Asp Ile Val Glu Tyr Tyr Asn Asp Ser Asn 
            100                 105                 110         


Gly Ser His Val Leu Gln Gly Arg Phe Gly Cys Glu Ile Glu Asn Asn 
        115                 120                 125             


Arg Ser Ser Gly Ala Phe Trp Lys Tyr Tyr Tyr Asp Gly Lys Asp Tyr 
    130                 135                 140                 


Ile Glu Phe Asn Lys Glu Ile Pro Ala Trp Val Pro Phe Asp Pro Ala 
145                 150                 155                 160 


Ala Gln Ile Thr Lys Gln Lys Trp Glu Ala Glu Pro Val Tyr Val Gln 
                165                 170                 175     


Arg Ala Lys Ala Tyr Leu Glu Glu Glu Cys Pro Ala Thr Leu Arg Lys 
            180                 185                 190         


Tyr Leu Lys Tyr Ser Lys Asn Ile Leu Asp Arg Gln Asp Pro Pro Ser 
        195                 200                 205             


Val Val Val Thr Ser His Gln Ala Pro Gly Glu Lys Lys Lys Leu Lys 
    210                 215                 220                 


Cys Leu Ala Tyr Asp Phe Tyr Pro Gly Lys Ile Asp Val His Trp Thr 
225                 230                 235                 240 


Arg Ala Gly Glu Val Gln Glu Pro Glu Leu Arg Gly Asp Val Leu His 
                245                 250                 255     


Asn Gly Asn Gly Thr Tyr Gln Ser Trp Val Val Val Ala Val Pro Pro 
            260                 265                 270         


Gln Asp Thr Ala Pro Tyr Ser Cys His Val Gln His Ser Ser Leu Ala 
        275                 280                 285             


Gln Pro Leu Val Val Pro Trp Glu Ala Ser 
    290                 295             


<210>  1292
<211>  85
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1292

Xaa Thr Tyr Ile Tyr Thr Gly Leu Ser Lys His Val Glu Asp Val Pro 
1               5                   10                  15      


Ala Phe Gln Ala Leu Gly Ser Leu Asn Asp Leu Gln Phe Phe Arg Tyr 
            20                  25                  30          


Asn Ser Lys Asp Arg Lys Ser Gln Pro Met Gly Leu Trp Arg Gln Gln 
        35                  40                  45              


Lys Tyr Pro Gly Pro Ala Arg Ser Ser Leu Cys Gly Gly His Gln Pro 
    50                  55                  60                  


Pro Gly Pro Arg Arg Lys Glu Glu Thr Glu Val Pro Gly Leu Arg Leu 
65                  70                  75                  80  


Leu Pro Arg Glu Asn 
                85  


<210>  1293
<211>  150
<212>  PRT
<213>  Homo Sapiens

<400>  1293

Met Thr Ala Ala Ser Cys Phe Gln Ser Gln Asn Pro Gly Val Ser Thr 
1               5                   10                  15      


Val Val Leu Gly Ala Tyr Asp Leu Arg Arg Arg Glu Arg Gln Ser Arg 
            20                  25                  30          


Gln Thr Phe Ser Ile Ser Ser Met Ser Glu Asn Gly Tyr Asp Pro Gln 
        35                  40                  45              


Gln Asn Leu Asn Asp Leu Met Leu Leu Gln Leu Asp Arg Glu Ala Asn 
    50                  55                  60                  


Leu Thr Ser Ser Val Thr Ile Leu Pro Leu Pro Leu Gln Asn Ala Thr 
65                  70                  75                  80  


Val Glu Ala Gly Thr Arg Cys Gln Val Ala Gly Trp Gly Ser Gln Arg 
                85                  90                  95      


Ser Gly Gly Arg Leu Ser Arg Phe Pro Arg Phe Val Asn Val Thr Val 
            100                 105                 110         


Thr Pro Glu Asp Gln Cys Arg Pro Asn Asn Val Cys Thr Gly Val Leu 
        115                 120                 125             


Thr Arg Arg Gly Gly Ile Cys Asn Val Ser Ala Pro Cys Gly Gly Arg 
    130                 135                 140                 


Arg Gly Pro Glu Arg Tyr 
145                 150 


<210>  1294
<211>  251
<212>  PRT
<213>  Homo Sapiens

<400>  1294

Met Thr Arg Leu Thr Val Leu Ala Leu Leu Ala Gly Leu Leu Ala Ser 
1               5                   10                  15      


Ser Arg Ala Gly Ser Ser Pro Leu Leu Asp Ile Val Gly Gly Arg Lys 
            20                  25                  30          


Ala Arg Pro Arg Gln Phe Pro Phe Leu Ala Ser Ile Gln Asn Gln Gly 
        35                  40                  45              


Arg His Phe Cys Gly Gly Ala Leu Ile His Ala Arg Phe Val Met Thr 
    50                  55                  60                  


Ala Ala Ser Cys Phe Gln Ser Gln Asn Pro Gly Val Ser Thr Val Val 
65                  70                  75                  80  


Leu Gly Ala Tyr Asp Leu Arg Arg Arg Glu Arg Gln Ser Arg Gln Thr 
                85                  90                  95      


Phe Ser Ile Ser Ser Met Ser Glu Asn Gly Tyr Asp Pro Gln Gln Asn 
            100                 105                 110         


Leu Asn Asp Leu Met Leu Leu Gln Leu Asp Arg Glu Ala Asn Leu Thr 
        115                 120                 125             


Ser Ser Val Thr Ile Leu Pro Leu Pro Leu Gln Asn Ala Thr Val Glu 
    130                 135                 140                 


Ala Gly Thr Arg Cys Gln Val Ala Gly Trp Gly Ser Gln Arg Ser Gly 
145                 150                 155                 160 


Gly Arg Leu Ser Arg Phe Pro Arg Phe Val Asn Val Thr Val Thr Pro 
                165                 170                 175     


Glu Asp Gln Cys Arg Pro Asn Asn Val Cys Thr Gly Val Leu Thr Arg 
            180                 185                 190         


Arg Gly Gly Ile Cys Asn Gly Asp Gly Gly Thr Pro Leu Val Cys Glu 
        195                 200                 205             


Gly Leu Ala His Gly Val Ala Ser Phe Ser Leu Gly Pro Cys Gly Arg 
    210                 215                 220                 


Gly Pro Asp Phe Phe Thr Arg Val Ala Leu Phe Arg Asp Trp Ile Asp 
225                 230                 235                 240 


Gly Val Leu Asn Asn Pro Gly Pro Gly Pro Ala 
                245                 250     


<210>  1295
<211>  71
<212>  PRT
<213>  Homo Sapiens

<400>  1295

Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
1               5                   10                  15      


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
            20                  25                  30          


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp 
        35                  40                  45              


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 
    50                  55                  60                  


Val Lys Trp Asp Arg Asp Met 
65                  70      


<210>  1296
<211>  51
<212>  PRT
<213>  Homo Sapiens

<400>  1296

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln His Ser Gly Leu Leu Thr Ser Ser Ser Arg 
            20                  25                  30          


Glu Trp Lys Val Lys Phe Pro Glu Leu Leu Cys Val Trp Val Ser Ser 
        35                  40                  45              


Ile Arg His 
    50      


<210>  1297
<211>  101
<212>  PRT
<213>  Homo Sapiens

<400>  1297

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu Arg Ile 
        35                  40                  45              


Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe 
    50                  55                  60                  


Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr 
65                  70                  75                  80  


Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys 
                85                  90                  95      


Trp Asp Arg Asp Met 
            100     


<210>  1298
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  1298

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met 
        115                 


<210>  1299
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  1299

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met 
        115                 


<210>  1300
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  1300

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met 
        115                 


<210>  1301
<211>  57
<212>  PRT
<213>  Homo Sapiens

<400>  1301

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Arg Glu Leu Lys Lys Trp Ser Ile Gln Thr Cys Leu Ser 
            20                  25                  30          


Ala Arg Thr Gly Leu Ser Ile Ser Cys Thr Thr Leu Asn Ser Pro Pro 
        35                  40                  45              


Leu Lys Lys Met Ser Met Pro Ala Val 
    50                  55          


<210>  1302
<211>  41
<212>  PRT
<213>  Homo Sapiens

<400>  1302

Met Ala Ser Ala Leu Trp Thr Val Leu Pro Ser Arg Met Ser Leu Arg 
1               5                   10                  15      


Ser Leu Lys Trp Ser Leu Leu Leu Leu Ser Leu Leu Ser Phe Phe Val 
            20                  25                  30          


Met Trp Tyr Leu Ser Leu Pro His Tyr 
        35                  40      


<210>  1303
<211>  46
<212>  PRT
<213>  Homo Sapiens

<400>  1303

Met Ala Ser Ala Leu Trp Thr Val Leu Pro Ser Arg Met Ser Leu Arg 
1               5                   10                  15      


Ser Leu Lys Trp Ser Leu Leu Leu Leu Ser Leu Leu Ser Phe Phe Val 
            20                  25                  30          


Met Trp Tyr Leu Ser Leu Pro His Tyr Asn Val Ile Glu Arg 
        35                  40                  45      


<210>  1304
<211>  54
<212>  PRT
<213>  Homo Sapiens

<400>  1304

Met Ala Ser Ala Leu Trp Thr Val Leu Pro Ser Arg Met Ser Leu Arg 
1               5                   10                  15      


Ser Leu Lys Trp Ser Leu Leu Leu Leu Ser Leu Leu Ser Phe Phe Val 
            20                  25                  30          


Met Trp Tyr Leu Ser Leu Pro His Tyr Asn Val Ile Glu Arg Val Asn 
        35                  40                  45              


Trp Met Tyr Phe Tyr Glu 
    50                  


<210>  1305
<211>  91
<212>  PRT
<213>  Homo Sapiens

<400>  1305

Met Ala Ser Ala Leu Trp Thr Val Leu Pro Ser Arg Met Ser Leu Arg 
1               5                   10                  15      


Ser Leu Lys Trp Ser Leu Leu Leu Leu Ser Leu Leu Ser Phe Phe Val 
            20                  25                  30          


Met Trp Tyr Leu Ser Leu Pro His Tyr Asn Val Ile Glu Arg Val Asn 
        35                  40                  45              


Trp Met Tyr Phe Tyr Glu Ile His Leu Asp Val Cys Gln Leu Arg Arg 
    50                  55                  60                  


Val Ile Ala Ala His Gly Phe Ser Ser Lys Glu Ile Ile Thr Phe Trp 
65                  70                  75                  80  


Gln Val Met Leu Arg Asn Thr Thr Cys His Tyr 
                85                  90      


<210>  1306
<211>  58
<212>  PRT
<213>  Homo Sapiens

<400>  1306

Met Ala Ser Ala Leu Trp Thr Val Leu Pro Ser Arg Met Ser Leu Arg 
1               5                   10                  15      


Ser Leu Lys Trp Ser Leu Leu Leu Leu Ser Leu Leu Ser Phe Phe Val 
            20                  25                  30          


Met Trp Tyr Leu Ser Leu Pro His Tyr Asn Val Ile Glu Arg Val Asn 
        35                  40                  45              


Trp Met Tyr Phe Tyr Glu Tyr Glu Pro Ile 
    50                  55              


<210>  1307
<211>  65
<212>  PRT
<213>  Homo Sapiens

<400>  1307

Met Ala Ser Ala Leu Trp Thr Val Leu Pro Ser Arg Met Ser Leu Arg 
1               5                   10                  15      


Ser Leu Lys Trp Ser Leu Leu Leu Leu Ser Leu Leu Ser Phe Phe Val 
            20                  25                  30          


Met Trp Tyr Leu Ser Leu Pro His Tyr Asn Val Ile Glu Arg Val Asn 
        35                  40                  45              


Trp Met Tyr Phe Tyr Glu Tyr Glu Pro Ile Tyr Arg Gln Asp Phe His 
    50                  55                  60                  


Phe 
65  


<210>  1308
<211>  111
<212>  PRT
<213>  Homo Sapiens

<400>  1308

Met Ala Ser Ala Leu Trp Thr Val Leu Pro Ser Arg Met Ser Leu Arg 
1               5                   10                  15      


Ser Leu Lys Trp Ser Leu Leu Leu Leu Ser Leu Leu Ser Phe Phe Val 
            20                  25                  30          


Met Trp Tyr Leu Ser Leu Pro His Tyr Asn Val Ile Glu Arg Val Asn 
        35                  40                  45              


Trp Met Tyr Phe Tyr Glu Tyr Glu Pro Ile Tyr Arg Gln Asp Phe His 
    50                  55                  60                  


Phe Thr Leu Arg Glu His Ser Asn Cys Ser His Gln Asn Pro Phe Leu 
65                  70                  75                  80  


Val Ile Leu Val Thr Ser His Pro Ser Asp Val Lys Ala Arg Gln Ala 
                85                  90                  95      


Ile Arg Val Thr Trp Gly Glu Lys Lys Ser Trp Trp Gly Tyr Glu 
            100                 105                 110     


<210>  1309
<211>  331
<212>  PRT
<213>  Homo Sapiens

<400>  1309

Met Ala Ser Ala Leu Trp Thr Val Leu Pro Ser Arg Met Ser Leu Arg 
1               5                   10                  15      


Ser Leu Lys Trp Ser Leu Leu Leu Leu Ser Leu Leu Ser Phe Phe Val 
            20                  25                  30          


Met Trp Tyr Leu Ser Leu Pro His Tyr Asn Val Ile Glu Arg Val Asn 
        35                  40                  45              


Trp Met Tyr Phe Tyr Glu Tyr Glu Pro Ile Tyr Arg Gln Asp Phe His 
    50                  55                  60                  


Phe Thr Leu Arg Glu His Ser Asn Cys Ser His Gln Asn Pro Phe Leu 
65                  70                  75                  80  


Val Ile Leu Val Thr Ser His Pro Ser Asp Val Lys Ala Arg Gln Ala 
                85                  90                  95      


Ile Arg Val Thr Trp Gly Glu Lys Lys Ser Trp Trp Gly Tyr Glu Val 
            100                 105                 110         


Leu Thr Phe Phe Leu Leu Gly Gln Glu Ala Glu Lys Glu Asp Lys Met 
        115                 120                 125             


Leu Ala Leu Ser Leu Glu Asp Glu His Leu Leu Tyr Gly Asp Ile Ile 
    130                 135                 140                 


Arg Gln Asp Phe Leu Asp Thr Tyr Asn Asn Leu Thr Leu Lys Thr Ile 
145                 150                 155                 160 


Met Ala Phe Arg Trp Val Thr Glu Phe Cys Pro Asn Ala Lys Tyr Val 
                165                 170                 175     


Met Lys Thr Asp Thr Asp Val Phe Ile Asn Thr Gly Asn Leu Val Lys 
            180                 185                 190         


Tyr Leu Leu Asn Leu Asn His Ser Glu Lys Phe Phe Thr Gly Tyr Pro 
        195                 200                 205             


Leu Ile Asp Asn Tyr Ser Tyr Arg Gly Phe Tyr Gln Lys Thr His Ile 
    210                 215                 220                 


Ser Tyr Gln Glu Tyr Pro Phe Lys Val Phe Pro Pro Tyr Cys Ser Gly 
225                 230                 235                 240 


Leu Gly Tyr Ile Met Ser Arg Asp Leu Val Pro Arg Ile Tyr Glu Met 
                245                 250                 255     


Met Gly His Val Lys Pro Ile Lys Phe Glu Asp Val Tyr Val Gly Ile 
            260                 265                 270         


Cys Leu Asn Leu Leu Lys Val Asn Ile His Ile Pro Glu Asp Thr Asn 
        275                 280                 285             


Leu Phe Phe Leu Tyr Arg Ile His Leu Asp Val Cys Gln Leu Arg Arg 
    290                 295                 300                 


Val Ile Ala Ala His Gly Phe Ser Ser Lys Glu Ile Ile Thr Phe Trp 
305                 310                 315                 320 


Gln Val Met Leu Arg Asn Thr Thr Cys His Tyr 
                325                 330     


<210>  1310
<211>  331
<212>  PRT
<213>  Homo Sapiens

<400>  1310

Met Ala Ser Ala Leu Trp Thr Val Leu Pro Ser Arg Met Ser Leu Arg 
1               5                   10                  15      


Ser Leu Lys Trp Ser Leu Leu Leu Leu Ser Leu Leu Ser Phe Phe Val 
            20                  25                  30          


Met Trp Tyr Leu Ser Leu Pro His Tyr Asn Val Ile Glu Arg Val Asn 
        35                  40                  45              


Trp Met Tyr Phe Tyr Glu Tyr Glu Pro Ile Tyr Arg Gln Asp Phe His 
    50                  55                  60                  


Phe Thr Leu Arg Glu His Ser Asn Cys Ser His Gln Asn Pro Phe Leu 
65                  70                  75                  80  


Val Ile Leu Val Thr Ser His Pro Ser Asp Val Lys Ala Arg Gln Ala 
                85                  90                  95      


Ile Arg Val Thr Trp Gly Glu Lys Lys Ser Trp Trp Gly Tyr Glu Val 
            100                 105                 110         


Leu Thr Phe Phe Leu Leu Gly Gln Glu Ala Glu Lys Glu Asp Lys Met 
        115                 120                 125             


Leu Ala Leu Ser Leu Glu Asp Glu His Leu Leu Tyr Gly Asp Ile Ile 
    130                 135                 140                 


Arg Gln Asp Phe Leu Asp Thr Tyr Asn Asn Leu Thr Leu Lys Thr Ile 
145                 150                 155                 160 


Met Ala Phe Arg Trp Val Thr Glu Phe Cys Pro Asn Ala Lys Tyr Val 
                165                 170                 175     


Met Lys Thr Asp Thr Asp Val Phe Ile Asn Thr Gly Asn Leu Val Lys 
            180                 185                 190         


Tyr Leu Leu Asn Leu Asn His Ser Glu Lys Phe Phe Thr Gly Tyr Pro 
        195                 200                 205             


Leu Ile Asp Asn Tyr Ser Tyr Arg Gly Phe Tyr Gln Lys Thr His Ile 
    210                 215                 220                 


Ser Tyr Gln Glu Tyr Pro Phe Lys Val Phe Pro Pro Tyr Cys Ser Gly 
225                 230                 235                 240 


Leu Gly Tyr Ile Met Ser Arg Asp Leu Val Pro Arg Ile Tyr Glu Met 
                245                 250                 255     


Met Gly His Val Lys Pro Ile Lys Phe Glu Asp Val Tyr Val Gly Ile 
            260                 265                 270         


Cys Leu Asn Leu Leu Lys Val Asn Ile His Ile Pro Glu Asp Thr Asn 
        275                 280                 285             


Leu Phe Phe Leu Tyr Arg Ile His Leu Asp Val Cys Gln Leu Arg Arg 
    290                 295                 300                 


Val Ile Ala Ala His Gly Phe Ser Ser Lys Glu Ile Ile Thr Phe Trp 
305                 310                 315                 320 


Gln Val Met Leu Arg Asn Thr Thr Cys His Tyr 
                325                 330     


<210>  1311
<211>  331
<212>  PRT
<213>  Homo Sapiens

<400>  1311

Met Ala Ser Ala Leu Trp Thr Val Leu Pro Ser Arg Met Ser Leu Arg 
1               5                   10                  15      


Ser Leu Lys Trp Ser Leu Leu Leu Leu Ser Leu Leu Ser Phe Phe Val 
            20                  25                  30          


Met Trp Tyr Leu Ser Leu Pro His Tyr Asn Val Ile Glu Arg Val Asn 
        35                  40                  45              


Trp Met Tyr Phe Tyr Glu Tyr Glu Pro Ile Tyr Arg Gln Asp Phe His 
    50                  55                  60                  


Phe Thr Leu Arg Glu His Ser Asn Cys Ser His Gln Asn Pro Phe Leu 
65                  70                  75                  80  


Val Ile Leu Val Thr Ser His Pro Ser Asp Val Lys Ala Arg Gln Ala 
                85                  90                  95      


Ile Arg Val Thr Trp Gly Glu Lys Lys Ser Trp Trp Gly Tyr Glu Val 
            100                 105                 110         


Leu Thr Phe Phe Leu Leu Gly Gln Glu Ala Glu Lys Glu Asp Lys Met 
        115                 120                 125             


Leu Ala Leu Ser Leu Glu Asp Glu His Leu Leu Tyr Gly Asp Ile Ile 
    130                 135                 140                 


Arg Gln Asp Phe Leu Asp Thr Tyr Asn Asn Leu Thr Leu Lys Thr Ile 
145                 150                 155                 160 


Met Ala Phe Arg Trp Val Thr Glu Phe Cys Pro Asn Ala Lys Tyr Val 
                165                 170                 175     


Met Lys Thr Asp Thr Asp Val Phe Ile Asn Thr Gly Asn Leu Val Lys 
            180                 185                 190         


Tyr Leu Leu Asn Leu Asn His Ser Glu Lys Phe Phe Thr Gly Tyr Pro 
        195                 200                 205             


Leu Ile Asp Asn Tyr Ser Tyr Arg Gly Phe Tyr Gln Lys Thr His Ile 
    210                 215                 220                 


Ser Tyr Gln Glu Tyr Pro Phe Lys Val Phe Pro Pro Tyr Cys Ser Gly 
225                 230                 235                 240 


Leu Gly Tyr Ile Met Ser Arg Asp Leu Val Pro Arg Ile Tyr Glu Met 
                245                 250                 255     


Met Gly His Val Lys Pro Ile Lys Phe Glu Asp Val Tyr Val Gly Ile 
            260                 265                 270         


Cys Leu Asn Leu Leu Lys Val Asn Ile His Ile Pro Glu Asp Thr Asn 
        275                 280                 285             


Leu Phe Phe Leu Tyr Arg Ile His Leu Asp Val Cys Gln Leu Arg Arg 
    290                 295                 300                 


Val Ile Ala Ala His Gly Phe Ser Ser Lys Glu Ile Ile Thr Phe Trp 
305                 310                 315                 320 


Gln Val Met Leu Arg Asn Thr Thr Cys His Tyr 
                325                 330     


<210>  1312
<211>  331
<212>  PRT
<213>  Homo Sapiens

<400>  1312

Met Ala Ser Ala Leu Trp Thr Val Leu Pro Ser Arg Met Ser Leu Arg 
1               5                   10                  15      


Ser Leu Lys Trp Ser Leu Leu Leu Leu Ser Leu Leu Ser Phe Phe Val 
            20                  25                  30          


Met Trp Tyr Leu Ser Leu Pro His Tyr Asn Val Ile Glu Arg Val Asn 
        35                  40                  45              


Trp Met Tyr Phe Tyr Glu Tyr Glu Pro Ile Tyr Arg Gln Asp Phe His 
    50                  55                  60                  


Phe Thr Leu Arg Glu His Ser Asn Cys Ser His Gln Asn Pro Phe Leu 
65                  70                  75                  80  


Val Ile Leu Val Thr Ser His Pro Ser Asp Val Lys Ala Arg Gln Ala 
                85                  90                  95      


Ile Arg Val Thr Trp Gly Glu Lys Lys Ser Trp Trp Gly Tyr Glu Val 
            100                 105                 110         


Leu Thr Phe Phe Leu Leu Gly Gln Glu Ala Glu Lys Glu Asp Lys Met 
        115                 120                 125             


Leu Ala Leu Ser Leu Glu Asp Glu His Leu Leu Tyr Gly Asp Ile Ile 
    130                 135                 140                 


Arg Gln Asp Phe Leu Asp Thr Tyr Asn Asn Leu Thr Leu Lys Thr Ile 
145                 150                 155                 160 


Met Ala Phe Arg Trp Val Thr Glu Phe Cys Pro Asn Ala Lys Tyr Val 
                165                 170                 175     


Met Lys Thr Asp Thr Asp Val Phe Ile Asn Thr Gly Asn Leu Val Lys 
            180                 185                 190         


Tyr Leu Leu Asn Leu Asn His Ser Glu Lys Phe Phe Thr Gly Tyr Pro 
        195                 200                 205             


Leu Ile Asp Asn Tyr Ser Tyr Arg Gly Phe Tyr Gln Lys Thr His Ile 
    210                 215                 220                 


Ser Tyr Gln Glu Tyr Pro Phe Lys Val Phe Pro Pro Tyr Cys Ser Gly 
225                 230                 235                 240 


Leu Gly Tyr Ile Met Ser Arg Asp Leu Val Pro Arg Ile Tyr Glu Met 
                245                 250                 255     


Met Gly His Val Lys Pro Ile Lys Phe Glu Asp Val Tyr Val Gly Ile 
            260                 265                 270         


Cys Leu Asn Leu Leu Lys Val Asn Ile His Ile Pro Glu Asp Thr Asn 
        275                 280                 285             


Leu Phe Phe Leu Tyr Arg Ile His Leu Asp Val Cys Gln Leu Arg Arg 
    290                 295                 300                 


Val Ile Ala Ala His Gly Phe Ser Ser Lys Glu Ile Ile Thr Phe Trp 
305                 310                 315                 320 


Gln Val Met Leu Arg Asn Thr Thr Cys His Tyr 
                325                 330     


<210>  1313
<211>  331
<212>  PRT
<213>  Homo Sapiens

<400>  1313

Met Ala Ser Ala Leu Trp Thr Val Leu Pro Ser Arg Met Ser Leu Arg 
1               5                   10                  15      


Ser Leu Lys Trp Ser Leu Leu Leu Leu Ser Leu Leu Ser Phe Phe Val 
            20                  25                  30          


Met Trp Tyr Leu Ser Leu Pro His Tyr Asn Val Ile Glu Arg Val Asn 
        35                  40                  45              


Trp Met Tyr Phe Tyr Glu Tyr Glu Pro Ile Tyr Arg Gln Asp Phe His 
    50                  55                  60                  


Phe Thr Leu Arg Glu His Ser Asn Cys Ser His Gln Asn Pro Phe Leu 
65                  70                  75                  80  


Val Ile Leu Val Thr Ser His Pro Ser Asp Val Lys Ala Arg Gln Ala 
                85                  90                  95      


Ile Arg Val Thr Trp Gly Glu Lys Lys Ser Trp Trp Gly Tyr Glu Val 
            100                 105                 110         


Leu Thr Phe Phe Leu Leu Gly Gln Glu Ala Glu Lys Glu Asp Lys Met 
        115                 120                 125             


Leu Ala Leu Ser Leu Glu Asp Glu His Leu Leu Tyr Gly Asp Ile Ile 
    130                 135                 140                 


Arg Gln Asp Phe Leu Asp Thr Tyr Asn Asn Leu Thr Leu Lys Thr Ile 
145                 150                 155                 160 


Met Ala Phe Arg Trp Val Thr Glu Phe Cys Pro Asn Ala Lys Tyr Val 
                165                 170                 175     


Met Lys Thr Asp Thr Asp Val Phe Ile Asn Thr Gly Asn Leu Val Lys 
            180                 185                 190         


Tyr Leu Leu Asn Leu Asn His Ser Glu Lys Phe Phe Thr Gly Tyr Pro 
        195                 200                 205             


Leu Ile Asp Asn Tyr Ser Tyr Arg Gly Phe Tyr Gln Lys Thr His Ile 
    210                 215                 220                 


Ser Tyr Gln Glu Tyr Pro Phe Lys Val Phe Pro Pro Tyr Cys Ser Gly 
225                 230                 235                 240 


Leu Gly Tyr Ile Met Ser Arg Asp Leu Val Pro Arg Ile Tyr Glu Met 
                245                 250                 255     


Met Gly His Val Lys Pro Ile Lys Phe Glu Asp Val Tyr Val Gly Ile 
            260                 265                 270         


Cys Leu Asn Leu Leu Lys Val Asn Ile His Ile Pro Glu Asp Thr Asn 
        275                 280                 285             


Leu Phe Phe Leu Tyr Arg Ile His Leu Asp Val Cys Gln Leu Arg Arg 
    290                 295                 300                 


Val Ile Ala Ala His Gly Phe Ser Ser Lys Glu Ile Ile Thr Phe Trp 
305                 310                 315                 320 


Gln Val Met Leu Arg Asn Thr Thr Cys His Tyr 
                325                 330     


<210>  1314
<211>  150
<212>  PRT
<213>  Homo Sapiens

<400>  1314

Met Ser Phe Phe Leu Phe Ser Glu Phe Thr Thr Asp Leu Ser Val Leu 
1               5                   10                  15      


Ile Lys His Gly Ile Gln Lys Thr Thr Lys Asn Leu Ser Phe Asn Phe 
            20                  25                  30          


Ile Trp Asn Ser Thr Val Phe Leu Ala Pro Trp Thr Arg Leu Thr Cys 
        35                  40                  45              


Trp Leu Phe Pro Leu Ala Ala Leu Ser Arg Gly Ala Leu Arg Leu Leu 
    50                  55                  60                  


Thr Pro Ser Val Lys Ser Cys Cys Ser Val Ala Gln Ala Gly Val Gln 
65                  70                  75                  80  


Trp Gln Asp Leu Ser Ser Leu Gln Ser Pro Ser Leu Arg Phe Lys Gln 
                85                  90                  95      


Phe Ser Cys Leu Ser Leu Pro Ser Arg Trp Asp Tyr Arg Thr Phe Gly 
            100                 105                 110         


Ser Arg Ala Ser Glu Leu Leu Trp Met Ala Ser Ala Leu Trp Thr Val 
        115                 120                 125             


Leu Pro Ser Arg Met Ser Leu Arg Ser Leu Lys Trp Ser Leu Leu Leu 
    130                 135                 140                 


Leu Ser Leu Leu Ser Phe 
145                 150 


<210>  1315
<211>  92
<212>  PRT
<213>  Homo Sapiens

<400>  1315

Met Arg Asn Trp Leu Val Leu Leu Cys Pro Cys Val Leu Gly Ala Ala 
1               5                   10                  15      


Leu His Leu Trp Leu Arg Leu Arg Ser Pro Pro Pro Ala Cys Ala Ser 
            20                  25                  30          


Gly Ala Gly Pro Ala Asp Gln Leu Ala Leu Phe Pro Gln Trp Lys Ser 
        35                  40                  45              


Thr His Tyr Asp Val Val Val Gly Val Leu Ser Ala Arg Asn Asn His 
    50                  55                  60                  


Glu Leu Arg Asn Val Ile Arg Ser Thr Trp Met Arg His Leu Leu Gln 
65                  70                  75                  80  


His Pro Thr Leu Ser Gln Arg Phe Glu Ser Gly Asn 
                85                  90          


<210>  1316
<211>  500
<212>  PRT
<213>  Homo Sapiens

<400>  1316

Met Arg Asn Trp Leu Val Leu Leu Cys Pro Cys Val Leu Gly Ala Ala 
1               5                   10                  15      


Leu His Leu Trp Leu Arg Leu Arg Ser Pro Pro Pro Ala Cys Ala Ser 
            20                  25                  30          


Gly Ala Gly Pro Ala Asp Gln Leu Ala Leu Phe Pro Gln Trp Lys Ser 
        35                  40                  45              


Thr His Tyr Asp Val Val Val Gly Val Leu Ser Ala Arg Asn Asn His 
    50                  55                  60                  


Glu Leu Arg Asn Val Ile Arg Ser Thr Trp Met Arg His Leu Leu Gln 
65                  70                  75                  80  


His Pro Thr Leu Ser Gln Arg Val Leu Val Lys Phe Ile Ile Gly Ala 
                85                  90                  95      


His Gly Cys Glu Val Pro Val Glu Asp Arg Glu Asp Pro Tyr Ser Cys 
            100                 105                 110         


Lys Leu Leu Asn Ile Thr Asn Pro Val Leu Asn Gln Glu Ile Glu Ala 
        115                 120                 125             


Phe Ser Leu Ser Glu Asp Thr Ser Ser Gly Leu Pro Glu Asp Arg Val 
    130                 135                 140                 


Val Ser Val Ser Phe Arg Val Leu Tyr Pro Ile Val Ile Thr Ser Leu 
145                 150                 155                 160 


Gly Val Phe Tyr Asp Ala Asn Asp Val Gly Phe Gln Arg Asn Ile Thr 
                165                 170                 175     


Val Lys Leu Tyr Gln Ala Glu Gln Glu Glu Ala Leu Phe Ile Ala Arg 
            180                 185                 190         


Phe Ser Pro Pro Ser Cys Gly Val Gln Val Asn Lys Leu Trp Tyr Lys 
        195                 200                 205             


Pro Val Glu Gln Phe Ile Leu Pro Glu Ser Phe Glu Gly Thr Ile Val 
    210                 215                 220                 


Trp Glu Ser Gln Asp Leu His Gly Leu Val Ser Arg Asn Leu His Lys 
225                 230                 235                 240 


Val Thr Val Asn Asp Gly Gly Gly Val Leu Arg Val Ile Thr Ala Gly 
                245                 250                 255     


Glu Gly Ala Leu Pro His Glu Phe Leu Glu Gly Val Glu Gly Val Ala 
            260                 265                 270         


Gly Gly Phe Ile Tyr Thr Ile Gln Glu Gly Asp Ala Leu Leu His Asn 
        275                 280                 285             


Leu His Ser Arg Pro Gln Arg Leu Ile Asp His Ile Arg Asn Leu His 
    290                 295                 300                 


Glu Glu Asp Ala Leu Leu Lys Glu Glu Ser Ser Ile Tyr Asp Asp Ile 
305                 310                 315                 320 


Val Phe Val Asp Val Val Asp Thr Tyr Arg Asn Val Pro Ala Lys Leu 
                325                 330                 335     


Leu Asn Phe Tyr Arg Trp Thr Val Glu Thr Thr Ser Phe Asn Leu Leu 
            340                 345                 350         


Leu Lys Thr Asp Asp Asp Cys Tyr Ile Asp Leu Glu Ala Val Phe Asn 
        355                 360                 365             


Arg Ile Val Gln Lys Asn Leu Asp Gly Pro Asn Phe Trp Trp Gly Asn 
    370                 375                 380                 


Phe Arg Leu Asn Trp Ala Val Asp Arg Thr Gly Lys Trp Gln Glu Leu 
385                 390                 395                 400 


Glu Tyr Pro Ser Pro Ala Tyr Pro Ala Phe Ala Cys Gly Ser Gly Tyr 
                405                 410                 415     


Val Ile Ser Lys Asp Ile Val Lys Trp Leu Ala Ser Asn Ser Gly Arg 
            420                 425                 430         


Leu Lys Thr Tyr Gln Gly Glu Asp Val Ser Met Gly Ile Trp Met Ala 
        435                 440                 445             


Ala Ile Gly Pro Lys Arg Tyr Gln Asp Ser Leu Trp Leu Cys Glu Lys 
    450                 455                 460                 


Thr Cys Glu Thr Gly Met Leu Ser Ser Pro Gln Tyr Ser Pro Trp Glu 
465                 470                 475                 480 


Leu Thr Glu Leu Trp Lys Leu Lys Glu Arg Cys Gly Asp Pro Cys Arg 
                485                 490                 495     


Cys Gln Ala Arg 
            500 


<210>  1317
<211>  326
<212>  PRT
<213>  Homo Sapiens

<400>  1317

Met Arg Asn Trp Leu Val Leu Leu Cys Pro Cys Val Leu Gly Ala Ala 
1               5                   10                  15      


Leu His Leu Trp Leu Arg Leu Arg Ser Pro Pro Pro Ala Cys Ala Ser 
            20                  25                  30          


Gly Ala Gly Pro Ala Gly Gly Val Ser Leu Leu Leu Pro Arg Leu Glu 
        35                  40                  45              


Cys Asn Gly Ala Val Ser Ala His Pro Asn Leu His Leu Pro Gly Ser 
    50                  55                  60                  


Arg Asp Ser Pro Ala Ser Ala Ser Gln Val Ala Gly Ile Thr Asp Gln 
65                  70                  75                  80  


Leu Ala Leu Phe Pro Gln Trp Lys Ser Thr His Tyr Asp Val Val Val 
                85                  90                  95      


Gly Val Leu Ser Ala Arg Asn Asn His Glu Leu Arg Asn Val Ile Arg 
            100                 105                 110         


Ser Thr Trp Met Arg His Leu Leu Gln His Pro Thr Leu Ser Gln Arg 
        115                 120                 125             


Val Leu Val Lys Phe Ile Ile Gly Ala His Gly Cys Glu Val Pro Val 
    130                 135                 140                 


Glu Asp Arg Glu Asp Pro Tyr Ser Cys Lys Leu Leu Asn Ile Thr Asn 
145                 150                 155                 160 


Pro Val Leu Asn Gln Glu Ile Glu Ala Phe Ser Leu Ser Glu Asp Thr 
                165                 170                 175     


Ser Ser Gly Leu Pro Glu Asp Arg Val Val Ser Val Ser Phe Arg Val 
            180                 185                 190         


Leu Tyr Pro Ile Val Ile Thr Ser Leu Gly Val Phe Tyr Asp Ala Asn 
        195                 200                 205             


Asp Val Gly Phe Gln Arg Asn Ile Thr Val Lys Leu Tyr Gln Ala Glu 
    210                 215                 220                 


Gln Glu Glu Ala Leu Phe Ile Ala Arg Phe Ser Pro Pro Ser Cys Gly 
225                 230                 235                 240 


Val Gln Val Asn Lys Leu Trp Tyr Lys Pro Val Glu Gln Phe Ile Leu 
                245                 250                 255     


Pro Glu Ser Phe Glu Gly Thr Ile Val Trp Glu Ser Gln Asp Leu His 
            260                 265                 270         


Gly Leu Val Ser Arg Asn Leu His Lys Val Thr Val Asn Asp Gly Gly 
        275                 280                 285             


Gly Val Leu Arg Val Ile Thr Ala Gly Glu Gly Ala Leu Pro His Glu 
    290                 295                 300                 


Phe Leu Glu Gly Val Glu Gly Val Ala Gly Gly Phe Ile Tyr Thr Ile 
305                 310                 315                 320 


Gln Gly Lys Phe Ala Ser 
                325     


<210>  1318
<211>  326
<212>  PRT
<213>  Homo Sapiens

<400>  1318

Met Ala Ser Lys Val Ser Cys Leu Tyr Val Leu Thr Val Val Cys Trp 
1               5                   10                  15      


Ala Ser Ala Leu Trp Tyr Leu Ser Ile Thr Arg Pro Thr Ser Ser Tyr 
            20                  25                  30          


Thr Gly Ser Lys Pro Phe Ser His Leu Thr Val Ala Arg Lys Asn Phe 
        35                  40                  45              


Thr Phe Gly Asn Ile Arg Thr Arg Pro Ile Asn Pro His Ser Phe Glu 
    50                  55                  60                  


Phe Leu Ile Asn Glu Pro Asn Lys Cys Glu Lys Asn Ile Pro Phe Leu 
65                  70                  75                  80  


Val Ile Leu Ile Ser Thr Thr His Lys Glu Phe Asp Ala Arg Gln Ala 
                85                  90                  95      


Ile Arg Glu Thr Trp Gly Asp Glu Asn Asn Phe Lys Gly Ile Lys Ile 
            100                 105                 110         


Ala Thr Leu Phe Leu Leu Gly Lys Asn Ala Asp Pro Val Leu Asn Gln 
        115                 120                 125             


Met Val Glu Gln Glu Ser Gln Ile Phe His Asp Ile Ile Val Glu Asp 
    130                 135                 140                 


Phe Ile Asp Ser Tyr His Asn Leu Thr Leu Lys Thr Leu Met Gly Met 
145                 150                 155                 160 


Arg Trp Val Ala Thr Phe Cys Ser Lys Ala Lys Tyr Val Met Lys Thr 
                165                 170                 175     


Asp Ser Asp Ile Phe Val Asn Met Asp Asn Leu Ile Tyr Lys Leu Leu 
            180                 185                 190         


Lys Pro Ser Thr Lys Pro Arg Arg Arg Tyr Phe Thr Gly Tyr Val Ile 
        195                 200                 205             


Asn Gly Gly Pro Ile Arg Asp Val Arg Ser Lys Trp Tyr Met Pro Arg 
    210                 215                 220                 


Asp Leu Tyr Pro Asp Ser Asn Tyr Pro Pro Phe Cys Ser Gly Thr Gly 
225                 230                 235                 240 


Tyr Ile Phe Ser Ala Asp Val Ala Glu Leu Ile Tyr Lys Thr Ser Leu 
                245                 250                 255     


His Thr Arg Leu Leu His Leu Glu Asp Val Tyr Val Gly Leu Cys Leu 
            260                 265                 270         


Arg Lys Leu Gly Ile His Pro Phe Gln Asn Ser Gly Phe Asn His Trp 
        275                 280                 285             


Lys Met Ala Tyr Ser Leu Cys Arg Tyr Arg Arg Val Ile Thr Val His 
    290                 295                 300                 


Gln Ile Ser Pro Glu Glu Met His Arg Ile Trp Asn Asp Met Ser Ser 
305                 310                 315                 320 


Lys Lys His Leu Arg Cys 
                325     


<210>  1319
<211>  378
<212>  PRT
<213>  Homo Sapiens

<400>  1319

Met Gln Leu Arg Leu Phe Arg Arg Leu Leu Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      


Val Ile Val Trp Thr Leu Phe Gly Pro Ser Gly Leu Gly Glu Glu Leu 
            20                  25                  30          


Leu Ser Leu Ser Leu Ala Ser Leu Leu Pro Ala Pro Ala Ser Pro Gly 
        35                  40                  45              


Pro Pro Leu Ala Leu Pro Arg Leu Leu Ile Pro Asn Gln Glu Ala Cys 
    50                  55                  60                  


Ser Gly Pro Gly Ala Pro Pro Phe Leu Leu Ile Leu Val Cys Thr Ala 
65                  70                  75                  80  


Pro Glu Asn Leu Asn Gln Arg Asn Ala Ile Arg Ala Ser Trp Gly Gly 
                85                  90                  95      


Leu Arg Glu Ala Arg Gly Leu Arg Val Gln Thr Leu Phe Leu Leu Gly 
            100                 105                 110         


Glu Pro Asn Ala Gln His Pro Val Trp Gly Ser Gln Gly Ser Asp Leu 
        115                 120                 125             


Ala Ser Glu Ser Ala Ala Gln Gly Asp Ile Leu Gln Ala Ala Phe Gln 
    130                 135                 140                 


Asp Ser Tyr Arg Asn Leu Thr Leu Lys Thr Leu Ser Gly Leu Asn Trp 
145                 150                 155                 160 


Ala Glu Lys His Cys Pro Met Ala Arg Tyr Val Leu Lys Thr Asp Asp 
                165                 170                 175     


Asp Val Tyr Val Asn Val Pro Glu Leu Val Ser Glu Leu Val Leu Arg 
            180                 185                 190         


Gly Gly Arg Trp Gly Gln Trp Glu Arg Ser Thr Glu Pro Gln Arg Glu 
        195                 200                 205             


Ala Glu Gln Glu Gly Gly Gln Val Leu His Ser Glu Glu Val Pro Leu 
    210                 215                 220                 


Leu Tyr Leu Gly Arg Val His Trp Arg Val Asn Pro Ser Arg Thr Pro 
225                 230                 235                 240 


Gly Gly Arg His Arg Val Ser Glu Glu Gln Trp Pro His Thr Trp Gly 
                245                 250                 255     


Pro Phe Pro Pro Tyr Ala Ser Gly Thr Gly Tyr Val Leu Ser Ala Ser 
            260                 265                 270         


Ala Val Gln Leu Ile Leu Lys Val Ala Ser Arg Ala Pro Leu Leu Pro 
        275                 280                 285             


Leu Glu Asp Val Phe Val Gly Val Ser Ala Arg Arg Gly Gly Leu Ala 
    290                 295                 300                 


Pro Thr Gln Cys Val Lys Leu Ala Gly Ala Thr His Tyr Pro Leu Asp 
305                 310                 315                 320 


Arg Cys Cys Tyr Gly Lys Phe Leu Leu Thr Ser His Arg Leu Asp Pro 
                325                 330                 335     


Trp Lys Met Gln Glu Ala Trp Lys Leu Val Gly Gly Ser Asp Gly Glu 
            340                 345                 350         


Arg Thr Ala Pro Phe Cys Ser Trp Phe Gln Gly Val Leu Gly Ile Leu 
        355                 360                 365             


Arg Cys Arg Ala Ile Ala Trp Leu Gln Ser 
    370                 375             


<210>  1320
<211>  310
<212>  PRT
<213>  Homo Sapiens

<400>  1320

Met Ala Phe Pro Lys Met Arg Leu Met Tyr Ile Cys Leu Leu Val Leu 
1               5                   10                  15      


Gly Ala Leu Cys Leu Tyr Phe Ser Met Tyr Ser Leu Asn Pro Phe Lys 
            20                  25                  30          


Glu Gln Ser Phe Val Tyr Lys Lys Asp Gly Asn Phe Leu Lys Leu Pro 
        35                  40                  45              


Asp Thr Asp Cys Arg Gln Thr Pro Pro Phe Leu Val Leu Leu Val Thr 
    50                  55                  60                  


Ser Ser His Lys Gln Leu Ala Glu Arg Met Ala Ile Arg Gln Thr Trp 
65                  70                  75                  80  


Gly Lys Glu Arg Met Val Lys Gly Lys Gln Leu Lys Thr Phe Phe Leu 
                85                  90                  95      


Leu Gly Thr Thr Ser Ser Ala Ala Glu Thr Lys Glu Val Asp Gln Glu 
            100                 105                 110         


Ser Gln Arg His Gly Asp Ile Ile Gln Lys Asp Phe Leu Asp Val Tyr 
        115                 120                 125             


Tyr Asn Leu Thr Leu Lys Thr Met Met Gly Ile Glu Trp Val His Arg 
    130                 135                 140                 


Phe Cys Pro Gln Ala Ala Phe Val Met Lys Thr Asp Ser Asp Met Phe 
145                 150                 155                 160 


Ile Asn Val Asp Tyr Leu Thr Glu Leu Leu Leu Lys Lys Asn Arg Thr 
                165                 170                 175     


Thr Arg Phe Phe Thr Gly Phe Leu Lys Leu Asn Glu Phe Pro Ile Arg 
            180                 185                 190         


Gln Pro Phe Ser Lys Trp Phe Val Ser Lys Ser Glu Tyr Pro Trp Asp 
        195                 200                 205             


Arg Tyr Pro Pro Phe Cys Ser Gly Thr Gly Tyr Val Phe Ser Gly Asp 
    210                 215                 220                 


Val Ala Ser Gln Val Tyr Asn Val Ser Lys Ser Val Pro Tyr Ile Lys 
225                 230                 235                 240 


Leu Glu Asp Val Phe Val Gly Leu Cys Leu Glu Arg Leu Asn Ile Arg 
                245                 250                 255     


Leu Glu Glu Leu His Ser Gln Pro Thr Phe Phe Pro Gly Gly Leu Arg 
            260                 265                 270         


Phe Ser Val Cys Leu Phe Arg Arg Ile Val Ala Cys His Phe Ile Lys 
        275                 280                 285             


Pro Arg Thr Leu Leu Asp Tyr Trp Gln Ala Leu Glu Asn Ser Arg Gly 
    290                 295                 300                 


Glu Asp Cys Pro Pro Val 
305                 310 


<210>  1321
<211>  310
<212>  PRT
<213>  Homo Sapiens

<400>  1321

Met Ala Phe Pro Lys Met Arg Leu Met Tyr Ile Cys Leu Leu Val Leu 
1               5                   10                  15      


Gly Ala Leu Cys Leu Tyr Phe Ser Met Tyr Ser Leu Asn Pro Phe Lys 
            20                  25                  30          


Glu Gln Ser Phe Val Tyr Lys Lys Asp Gly Asn Phe Leu Lys Leu Pro 
        35                  40                  45              


Asp Thr Asp Cys Arg Gln Thr Pro Pro Phe Leu Val Leu Leu Val Thr 
    50                  55                  60                  


Ser Ser His Lys Gln Leu Ala Glu Arg Met Ala Ile Arg Gln Thr Trp 
65                  70                  75                  80  


Gly Lys Glu Arg Met Val Lys Gly Lys Gln Leu Lys Thr Phe Phe Leu 
                85                  90                  95      


Leu Gly Thr Thr Ser Ser Ala Ala Glu Thr Lys Glu Val Asp Gln Glu 
            100                 105                 110         


Ser Gln Arg His Gly Asp Ile Ile Gln Lys Asp Phe Leu Asp Val Tyr 
        115                 120                 125             


Tyr Asn Leu Thr Leu Lys Thr Met Met Gly Ile Glu Trp Val His Arg 
    130                 135                 140                 


Phe Cys Pro Gln Ala Ala Phe Val Met Lys Thr Asp Ser Asp Met Phe 
145                 150                 155                 160 


Ile Asn Val Asp Tyr Leu Thr Glu Leu Leu Leu Lys Lys Asn Arg Thr 
                165                 170                 175     


Thr Arg Phe Phe Thr Gly Phe Leu Lys Leu Asn Glu Phe Pro Ile Arg 
            180                 185                 190         


Gln Pro Phe Ser Lys Trp Phe Val Ser Lys Ser Glu Tyr Pro Trp Asp 
        195                 200                 205             


Arg Tyr Pro Pro Phe Cys Ser Gly Thr Gly Tyr Val Phe Ser Gly Asp 
    210                 215                 220                 


Val Ala Ser Gln Val Tyr Asn Val Ser Lys Ser Val Pro Tyr Ile Lys 
225                 230                 235                 240 


Leu Glu Asp Val Phe Val Gly Leu Cys Leu Glu Arg Leu Asn Ile Arg 
                245                 250                 255     


Leu Glu Glu Leu His Ser Gln Pro Thr Phe Phe Pro Gly Gly Leu Arg 
            260                 265                 270         


Phe Ser Val Cys Leu Phe Arg Arg Ile Val Ala Cys His Phe Ile Lys 
        275                 280                 285             


Pro Arg Thr Leu Leu Asp Tyr Trp Gln Ala Leu Glu Asn Ser Arg Gly 
    290                 295                 300                 


Glu Asp Cys Pro Pro Val 
305                 310 


<210>  1322
<211>  310
<212>  PRT
<213>  Homo Sapiens

<400>  1322

Met Ala Phe Pro Lys Met Arg Leu Met Tyr Ile Cys Leu Leu Val Leu 
1               5                   10                  15      


Gly Ala Leu Cys Leu Tyr Phe Ser Met Tyr Ser Leu Asn Pro Phe Lys 
            20                  25                  30          


Glu Gln Ser Phe Val Tyr Lys Lys Asp Gly Asn Phe Leu Lys Leu Pro 
        35                  40                  45              


Asp Thr Asp Cys Arg Gln Thr Pro Pro Phe Leu Val Leu Leu Val Thr 
    50                  55                  60                  


Ser Ser His Lys Gln Leu Ala Glu Arg Met Ala Ile Arg Gln Thr Trp 
65                  70                  75                  80  


Gly Lys Glu Arg Met Val Lys Gly Lys Gln Leu Lys Thr Phe Phe Leu 
                85                  90                  95      


Leu Gly Thr Thr Ser Ser Ala Ala Glu Thr Lys Glu Val Asp Gln Glu 
            100                 105                 110         


Ser Gln Arg His Gly Asp Ile Ile Gln Lys Asp Phe Leu Asp Val Tyr 
        115                 120                 125             


Tyr Asn Leu Thr Leu Lys Thr Met Met Gly Ile Glu Trp Val His Arg 
    130                 135                 140                 


Phe Cys Pro Gln Ala Ala Phe Val Met Lys Thr Asp Ser Asp Met Phe 
145                 150                 155                 160 


Ile Asn Val Asp Tyr Leu Thr Glu Leu Leu Leu Lys Lys Asn Arg Thr 
                165                 170                 175     


Thr Arg Phe Phe Thr Gly Phe Leu Lys Leu Asn Glu Phe Pro Ile Arg 
            180                 185                 190         


Gln Pro Phe Ser Lys Trp Phe Val Ser Lys Ser Glu Tyr Pro Trp Asp 
        195                 200                 205             


Arg Tyr Pro Pro Phe Cys Ser Gly Thr Gly Tyr Val Phe Ser Gly Asp 
    210                 215                 220                 


Val Ala Ser Gln Val Tyr Asn Val Ser Lys Ser Val Pro Tyr Ile Lys 
225                 230                 235                 240 


Leu Glu Asp Val Phe Val Gly Leu Cys Leu Glu Arg Leu Asn Ile Arg 
                245                 250                 255     


Leu Glu Glu Leu His Ser Gln Pro Thr Phe Phe Pro Gly Gly Leu Arg 
            260                 265                 270         


Phe Ser Val Cys Leu Phe Arg Arg Ile Val Ala Cys His Phe Ile Lys 
        275                 280                 285             


Pro Arg Thr Leu Leu Asp Tyr Trp Gln Ala Leu Glu Asn Ser Arg Gly 
    290                 295                 300                 


Glu Asp Cys Pro Pro Val 
305                 310 


<210>  1323
<211>  310
<212>  PRT
<213>  Homo Sapiens

<400>  1323

Met Ala Phe Pro Lys Met Arg Leu Met Tyr Ile Cys Leu Leu Val Leu 
1               5                   10                  15      


Gly Ala Leu Cys Leu Tyr Phe Ser Met Tyr Ser Leu Asn Pro Phe Lys 
            20                  25                  30          


Glu Gln Ser Phe Val Tyr Lys Lys Asp Gly Asn Phe Leu Lys Leu Pro 
        35                  40                  45              


Asp Thr Asp Cys Arg Gln Thr Pro Pro Phe Leu Val Leu Leu Val Thr 
    50                  55                  60                  


Ser Ser His Lys Gln Leu Ala Glu Arg Met Ala Ile Arg Gln Thr Trp 
65                  70                  75                  80  


Gly Lys Glu Arg Met Val Lys Gly Lys Gln Leu Lys Thr Phe Phe Leu 
                85                  90                  95      


Leu Gly Thr Thr Ser Ser Ala Ala Glu Thr Lys Glu Val Asp Gln Glu 
            100                 105                 110         


Ser Gln Arg His Gly Asp Ile Ile Gln Lys Asp Phe Leu Asp Val Tyr 
        115                 120                 125             


Tyr Asn Leu Thr Leu Lys Thr Met Met Gly Ile Glu Trp Val His Arg 
    130                 135                 140                 


Phe Cys Pro Gln Ala Ala Phe Val Met Lys Thr Asp Ser Asp Met Phe 
145                 150                 155                 160 


Ile Asn Val Asp Tyr Leu Thr Glu Leu Leu Leu Lys Lys Asn Arg Thr 
                165                 170                 175     


Thr Arg Phe Phe Thr Gly Phe Leu Lys Leu Asn Glu Phe Pro Ile Arg 
            180                 185                 190         


Gln Pro Phe Ser Lys Trp Phe Val Ser Lys Ser Glu Tyr Pro Trp Asp 
        195                 200                 205             


Arg Tyr Pro Pro Phe Cys Ser Gly Thr Gly Tyr Val Phe Ser Gly Asp 
    210                 215                 220                 


Val Ala Ser Gln Val Tyr Asn Val Ser Lys Ser Val Pro Tyr Ile Lys 
225                 230                 235                 240 


Leu Glu Asp Val Phe Val Gly Leu Cys Leu Glu Arg Leu Asn Ile Arg 
                245                 250                 255     


Leu Glu Glu Leu His Ser Gln Pro Thr Phe Phe Pro Gly Gly Leu Arg 
            260                 265                 270         


Phe Ser Val Cys Leu Phe Arg Arg Ile Val Ala Cys His Phe Ile Lys 
        275                 280                 285             


Pro Arg Thr Leu Leu Asp Tyr Trp Gln Ala Leu Glu Asn Ser Arg Gly 
    290                 295                 300                 


Glu Asp Cys Pro Pro Val 
305                 310 


<210>  1324
<211>  314
<212>  PRT
<213>  Homo Sapiens

<400>  1324

Met Cys Leu Glu Met Ala Phe Pro Lys Met Arg Leu Met Tyr Ile Cys 
1               5                   10                  15      


Leu Leu Val Leu Gly Ala Leu Cys Leu Tyr Phe Ser Met Tyr Ser Leu 
            20                  25                  30          


Asn Pro Phe Lys Glu Gln Ser Phe Val Tyr Lys Lys Asp Gly Asn Phe 
        35                  40                  45              


Leu Lys Leu Pro Asp Thr Asp Cys Arg Gln Thr Pro Pro Phe Leu Val 
    50                  55                  60                  


Leu Leu Val Thr Ser Ser His Lys Gln Leu Ala Glu Arg Met Ala Ile 
65                  70                  75                  80  


Arg Gln Thr Trp Gly Lys Glu Arg Met Val Lys Gly Lys Gln Leu Lys 
                85                  90                  95      


Thr Phe Phe Leu Leu Gly Thr Thr Ser Ser Ala Ala Glu Thr Lys Glu 
            100                 105                 110         


Val Asp Gln Glu Ser Gln Arg His Gly Asp Ile Ile Gln Lys Asp Phe 
        115                 120                 125             


Leu Asp Val Tyr Tyr Asn Leu Thr Leu Lys Thr Met Met Gly Ile Glu 
    130                 135                 140                 


Trp Val His Arg Phe Cys Pro Gln Ala Ala Phe Val Met Lys Thr Asp 
145                 150                 155                 160 


Ser Asp Met Phe Ile Asn Val Asp Tyr Leu Thr Glu Leu Leu Leu Lys 
                165                 170                 175     


Lys Asn Arg Thr Thr Arg Phe Phe Thr Gly Phe Leu Lys Leu Asn Glu 
            180                 185                 190         


Phe Pro Ile Arg Gln Pro Phe Ser Lys Trp Phe Val Ser Lys Ser Glu 
        195                 200                 205             


Tyr Pro Trp Asp Arg Tyr Pro Pro Phe Cys Ser Gly Thr Gly Tyr Val 
    210                 215                 220                 


Phe Ser Gly Asp Val Ala Ser Gln Val Tyr Asn Val Ser Lys Ser Val 
225                 230                 235                 240 


Pro Tyr Ile Lys Leu Glu Asp Val Phe Val Gly Leu Cys Leu Glu Arg 
                245                 250                 255     


Leu Asn Ile Arg Leu Glu Glu Leu His Ser Gln Pro Thr Phe Phe Pro 
            260                 265                 270         


Gly Gly Leu Arg Phe Ser Val Cys Leu Phe Arg Arg Ile Val Ala Cys 
        275                 280                 285             


His Phe Ile Lys Pro Arg Thr Leu Leu Asp Tyr Trp Gln Ala Leu Glu 
    290                 295                 300                 


Asn Ser Arg Gly Glu Asp Cys Pro Pro Val 
305                 310                 


<210>  1325
<211>  329
<212>  PRT
<213>  Homo Sapiens

<400>  1325

Met Lys Leu Leu Arg Arg Ala Trp Arg Arg Arg Ala Ala Leu Gly Leu 
1               5                   10                  15      


Gly Thr Leu Ala Leu Cys Gly Ala Ala Leu Leu Tyr Leu Ala Arg Cys 
            20                  25                  30          


Ala Ala Glu Pro Gly Asp Pro Arg Ala Met Ser Gly Arg Ser Pro Pro 
        35                  40                  45              


Pro Pro Ala Pro Ala Arg Ala Ala Ala Phe Leu Ala Val Leu Val Ala 
    50                  55                  60                  


Ser Ala Pro Arg Ala Ala Glu Arg Arg Ser Val Ile Arg Ser Thr Trp 
65                  70                  75                  80  


Leu Ala Arg Arg Gly Ala Pro Gly Asp Val Trp Ala Arg Phe Ala Val 
                85                  90                  95      


Gly Thr Ala Gly Leu Gly Ala Glu Glu Arg Arg Ala Leu Glu Arg Glu 
            100                 105                 110         


Gln Ala Arg His Gly Asp Leu Leu Leu Leu Pro Ala Leu Arg Asp Ala 
        115                 120                 125             


Tyr Glu Asn Leu Thr Ala Lys Val Leu Ala Met Leu Ala Trp Leu Asp 
    130                 135                 140                 


Glu His Val Ala Phe Glu Phe Val Leu Lys Ala Asp Asp Asp Ser Phe 
145                 150                 155                 160 


Ala Arg Leu Asp Ala Leu Leu Ala Glu Leu Arg Ala Arg Glu Pro Ala 
                165                 170                 175     


Arg Arg Arg Arg Leu Tyr Trp Gly Phe Phe Ser Gly Arg Gly Arg Val 
            180                 185                 190         


Lys Pro Gly Gly Arg Trp Arg Glu Ala Ala Trp Gln Leu Cys Asp Tyr 
        195                 200                 205             


Tyr Leu Pro Tyr Ala Leu Gly Gly Gly Tyr Val Leu Ser Ala Asp Leu 
    210                 215                 220                 


Val His Tyr Leu Arg Leu Ser Arg Asp Tyr Leu Arg Ala Trp His Ser 
225                 230                 235                 240 


Glu Asp Val Ser Leu Gly Ala Trp Leu Ala Pro Val Asp Val Gln Arg 
                245                 250                 255     


Glu His Asp Pro Arg Phe Asp Thr Glu Tyr Arg Ser Arg Gly Cys Ser 
            260                 265                 270         


Asn Gln Tyr Leu Val Thr His Lys Gln Ser Leu Glu Asp Met Leu Glu 
        275                 280                 285             


Lys His Ala Thr Leu Ala Arg Glu Gly Arg Leu Cys Lys Arg Glu Val 
    290                 295                 300                 


Gln Leu Arg Leu Ser Tyr Val Tyr Asp Trp Ser Ala Pro Pro Ser Gln 
305                 310                 315                 320 


Cys Cys Gln Arg Arg Glu Gly Ile Pro 
                325                 


<210>  1326
<211>  223
<212>  PRT
<213>  Homo Sapiens

<400>  1326

Met Lys Leu Lys Leu Lys Asn Val Phe Leu Ala Tyr Phe Leu Val Ser 
1               5                   10                  15      


Ile Ala Gly Leu Leu Tyr Ala Leu Val Gln Leu Ala Lys Gly Met Asp 
            20                  25                  30          


Arg Thr Leu Pro Leu Met Gln Arg Phe Arg Asp Ser Ala Thr Ala Leu 
        35                  40                  45              


Ser Ser Gly Gln Pro Cys Asp Cys Leu Pro Pro Leu Arg Ala Ala Ala 
    50                  55                  60                  


Glu Gln Leu Arg Gln Lys Asp Leu Arg Ile Ser Gln Leu Gln Ala Glu 
65                  70                  75                  80  


Leu Arg Arg Pro Pro Pro Ala Pro Ala Gln Pro Pro Glu Pro Glu Ala 
                85                  90                  95      


Leu Pro Thr Ile Tyr Val Val Thr Pro Thr Tyr Ala Arg Leu Val Gln 
            100                 105                 110         


Lys Ala Glu Leu Val Arg Leu Ser Gln Thr Leu Ser Leu Val Pro Arg 
        115                 120                 125             


Leu His Trp Leu Leu Val Glu Asp Ala Glu Gly Pro Thr Pro Leu Val 
    130                 135                 140                 


Ser Gly Leu Leu Ala Ala Ser Gly Leu Leu Phe Thr His Leu Val Val 
145                 150                 155                 160 


Leu Thr Pro Lys Ala Gln Arg Leu Arg Glu Gly Glu Pro Gly Trp Val 
                165                 170                 175     


His Pro Arg Gly Val Glu Gln Arg Asn Lys Ala Leu Asp Trp Leu Arg 
            180                 185                 190         


Gly Arg Gly Gly Ala Val Gly Gly Glu Lys Asp Pro Pro Pro Pro Gly 
        195                 200                 205             


Thr Gln Gly Val Val Tyr Phe Ala Asp Asp Asp Asn Thr Tyr Ser 
    210                 215                 220             


<210>  1327
<211>  335
<212>  PRT
<213>  Homo Sapiens

<400>  1327

Met Lys Leu Lys Leu Lys Asn Val Phe Leu Ala Tyr Phe Leu Val Ser 
1               5                   10                  15      


Ile Ala Gly Leu Leu Tyr Ala Leu Val Gln Leu Gly Gln Pro Cys Asp 
            20                  25                  30          


Cys Leu Pro Pro Leu Arg Ala Ala Ala Glu Gln Leu Arg Gln Lys Asp 
        35                  40                  45              


Leu Arg Ile Ser Gln Leu Gln Ala Glu Leu Arg Arg Pro Pro Pro Ala 
    50                  55                  60                  


Pro Ala Gln Pro Pro Glu Pro Glu Ala Leu Pro Thr Ile Tyr Val Val 
65                  70                  75                  80  


Thr Pro Thr Tyr Ala Arg Leu Val Gln Lys Ala Glu Leu Val Arg Leu 
                85                  90                  95      


Ser Gln Thr Leu Ser Leu Val Pro Arg Leu His Trp Leu Leu Val Glu 
            100                 105                 110         


Asp Ala Glu Gly Pro Thr Pro Leu Val Ser Gly Leu Leu Ala Ala Ser 
        115                 120                 125             


Gly Leu Leu Phe Thr His Leu Val Val Leu Thr Pro Lys Ala Gln Arg 
    130                 135                 140                 


Leu Arg Glu Gly Glu Pro Gly Trp Val His Pro Arg Gly Val Glu Gln 
145                 150                 155                 160 


Arg Asn Lys Ala Leu Asp Trp Leu Arg Gly Arg Gly Gly Ala Val Gly 
                165                 170                 175     


Gly Glu Lys Asp Pro Pro Pro Pro Gly Thr Gln Gly Val Val Tyr Phe 
            180                 185                 190         


Ala Asp Asp Asp Asn Thr Tyr Ser Arg Glu Leu Phe Glu Glu Met Arg 
        195                 200                 205             


Trp Thr Arg Gly Val Ser Val Trp Pro Val Gly Leu Val Gly Gly Leu 
    210                 215                 220                 


Arg Phe Glu Gly Pro Gln Val Gln Asp Gly Arg Val Val Gly Phe His 
225                 230                 235                 240 


Thr Ala Trp Glu Pro Ser Arg Pro Phe Pro Val Asp Met Ala Gly Phe 
                245                 250                 255     


Ala Val Ala Leu Pro Leu Leu Leu Asp Lys Pro Asn Ala Gln Phe Asp 
            260                 265                 270         


Ser Thr Ala Pro Arg Gly His Leu Glu Ser Ser Leu Leu Ser His Leu 
        275                 280                 285             


Val Asp Pro Lys Asp Leu Glu Pro Arg Ala Ala Asn Cys Thr Arg Val 
    290                 295                 300                 


Leu Val Trp His Thr Arg Thr Glu Lys Pro Lys Met Lys Gln Glu Glu 
305                 310                 315                 320 


Gln Leu Gln Arg Gln Gly Arg Gly Ser Asp Pro Ala Ile Glu Val 
                325                 330                 335 


<210>  1328
<211>  319
<212>  PRT
<213>  Homo Sapiens

<400>  1328

Met Lys Leu Lys Leu Lys Asn Val Phe Leu Ala Tyr Phe Leu Val Ser 
1               5                   10                  15      


Ile Ala Gly Leu Leu Tyr Ala Leu Val Gln Leu Gly Gln Pro Cys Asp 
            20                  25                  30          


Cys Leu Pro Pro Leu Arg Ala Ala Ala Glu Gln Leu Arg Gln Lys Asp 
        35                  40                  45              


Leu Arg Ile Ser Gln Leu Gln Ala Glu Leu Arg Arg Pro Pro Pro Ala 
    50                  55                  60                  


Pro Ala Gln Pro Pro Glu Pro Glu Ala Leu Pro Thr Ile Tyr Val Val 
65                  70                  75                  80  


Thr Pro Thr Tyr Ala Arg Leu Val Gln Lys Ala Glu Leu Val Arg Leu 
                85                  90                  95      


Ser Gln Thr Leu Ser Leu Val Pro Arg Leu His Trp Leu Leu Val Glu 
            100                 105                 110         


Asp Ala Glu Gly Pro Thr Pro Leu Val Ser Gly Leu Leu Ala Ala Ser 
        115                 120                 125             


Gly Leu Leu Phe Thr His Leu Val Val Leu Thr Pro Lys Ala Gln Arg 
    130                 135                 140                 


Leu Arg Glu Gly Glu Pro Gly Trp Val His Pro Arg Gly Val Glu Gln 
145                 150                 155                 160 


Arg Asn Lys Ala Leu Asp Trp Leu Arg Gly Arg Gly Gly Ala Val Gly 
                165                 170                 175     


Gly Glu Lys Asp Pro Pro Pro Pro Gly Thr Gln Gly Val Val Tyr Phe 
            180                 185                 190         


Ala Asp Asp Asp Asn Thr Tyr Ser Arg Glu Leu Phe Glu Glu Met Arg 
        195                 200                 205             


Trp Thr Arg Gly Val Ser Val Trp Pro Val Gly Leu Val Gly Gly Leu 
    210                 215                 220                 


Arg Phe Glu Gly Pro Gln Val Gln Asp Gly Arg Val Val Gly Phe His 
225                 230                 235                 240 


Thr Ala Trp Glu Pro Ser Arg Pro Phe Pro Val Asp Met Ala Gly Phe 
                245                 250                 255     


Ala Val Ala Leu Pro Leu Leu Leu Asp Lys Pro Asn Ala Gln Phe Asp 
            260                 265                 270         


Ser Thr Ala Pro Arg Gly His Leu Glu Ser Ser Leu Leu Ser His Leu 
        275                 280                 285             


Val Asp Pro Lys Asp Leu Glu Pro Arg Ala Ala Asn Cys Thr Arg Ser 
    290                 295                 300                 


Leu Ala Val Ser Pro Arg Leu Glu Cys Ser Ser Ala Ile Leu Ala 
305                 310                 315                 


<210>  1329
<211>  315
<212>  PRT
<213>  Homo Sapiens

<400>  1329

Met Lys Leu Lys Leu Lys Asn Val Phe Leu Ala Tyr Phe Leu Val Ser 
1               5                   10                  15      


Ile Ala Gly Leu Leu Tyr Ala Leu Val Gln Leu Gly Gln Pro Cys Asp 
            20                  25                  30          


Cys Leu Pro Pro Leu Arg Ala Ala Ala Glu Gln Leu Arg Gln Lys Asp 
        35                  40                  45              


Leu Arg Ile Ser Gln Leu Gln Ala Glu Leu Arg Arg Pro Pro Pro Ala 
    50                  55                  60                  


Pro Ala Gln Pro Pro Glu Pro Glu Ala Leu Pro Thr Ile Tyr Val Val 
65                  70                  75                  80  


Thr Pro Thr Tyr Ala Arg Leu Val Gln Lys Ala Glu Leu Val Arg Leu 
                85                  90                  95      


Ser Gln Thr Leu Ser Leu Val Pro Arg Leu His Trp Leu Leu Val Glu 
            100                 105                 110         


Asp Ala Glu Gly Pro Thr Pro Leu Val Ser Gly Leu Leu Ala Ala Ser 
        115                 120                 125             


Gly Leu Leu Phe Thr His Leu Val Val Leu Thr Pro Lys Ala Gln Arg 
    130                 135                 140                 


Leu Arg Glu Gly Glu Pro Gly Trp Val His Pro Arg Gly Val Glu Gln 
145                 150                 155                 160 


Arg Asn Lys Ala Leu Asp Trp Leu Arg Gly Arg Gly Gly Ala Val Gly 
                165                 170                 175     


Gly Glu Lys Asp Pro Pro Pro Pro Gly Thr Gln Gly Val Val Tyr Phe 
            180                 185                 190         


Ala Asp Asp Asp Asn Thr Tyr Ser Arg Glu Leu Phe Glu Glu Met Arg 
        195                 200                 205             


Trp Thr Arg Gly Val Ser Val Trp Pro Val Gly Leu Val Gly Gly Leu 
    210                 215                 220                 


Arg Phe Glu Gly Pro Gln Val Gln Asp Gly Arg Val Val Gly Phe His 
225                 230                 235                 240 


Thr Ala Trp Glu Pro Ser Arg Pro Phe Pro Val Asp Met Ala Gly Phe 
                245                 250                 255     


Ala Val Ala Leu Pro Leu Leu Leu Asp Lys Pro Asn Ala Gln Phe Asp 
            260                 265                 270         


Ser Thr Ala Pro Arg Gly His Leu Glu Ser Ser Leu Leu Ser His Leu 
        275                 280                 285             


Val Asp Pro Lys Asp Leu Glu Pro Arg Ala Ala Asn Cys Thr Arg Thr 
    290                 295                 300                 


Glu Ser Arg Cys Val Thr Gln Ala Gly Val Gln 
305                 310                 315 


<210>  1330
<211>  38
<212>  PRT
<213>  Homo Sapiens

<400>  1330

Met Lys Leu Lys Leu Lys Asn Val Phe Leu Ala Tyr Phe Leu Val Ser 
1               5                   10                  15      


Ile Ala Gly Leu Leu Tyr Ala Leu Val Gln Leu Val Ser Ala Ser Ser 
            20                  25                  30          


Thr Lys Gln Lys Ala Arg 
        35              


<210>  1331
<211>  498
<212>  PRT
<213>  Homo Sapiens

<400>  1331

Met Arg Pro Pro Ala Cys Trp Trp Leu Leu Ala Pro Pro Ala Leu Leu 
1               5                   10                  15      


Ala Leu Leu Thr Cys Ser Leu Ala Phe Gly Leu Ala Ser Glu Asp Thr 
            20                  25                  30          


Lys Lys Glu Val Lys Gln Ser Gln Asp Leu Glu Lys Ser Gly Ile Ser 
        35                  40                  45              


Arg Lys Asn Asp Ile Asp Leu Lys Gly Ile Val Phe Val Ile Gln Ser 
    50                  55                  60                  


Gln Ser Asn Ser Phe His Ala Lys Arg Ala Glu Gln Leu Lys Lys Ser 
65                  70                  75                  80  


Ile Leu Lys Gln Ala Ala Asp Leu Thr Gln Glu Leu Pro Ser Val Leu 
                85                  90                  95      


Leu Leu His Gln Leu Ala Lys Gln Glu Gly Ala Trp Thr Ile Leu Pro 
            100                 105                 110         


Leu Leu Pro His Phe Ser Val Thr Tyr Ser Arg Asn Ser Ser Trp Ile 
        115                 120                 125             


Phe Phe Cys Glu Glu Glu Thr Arg Ile Gln Ile Pro Lys Leu Leu Glu 
    130                 135                 140                 


Thr Leu Arg Arg Tyr Asp Pro Ser Lys Glu Trp Phe Leu Gly Lys Ala 
145                 150                 155                 160 


Leu His Asp Glu Glu Ala Thr Ile Ile His His Tyr Ala Phe Ser Glu 
                165                 170                 175     


Asn Pro Thr Val Phe Lys Tyr Pro Asp Phe Ala Ala Gly Trp Ala Leu 
            180                 185                 190         


Ser Ile Pro Leu Val Asn Lys Leu Thr Lys Arg Leu Lys Ser Glu Ser 
        195                 200                 205             


Leu Lys Ser Asp Phe Thr Ile Asp Leu Lys His Glu Ile Ala Leu Tyr 
    210                 215                 220                 


Ile Trp Asp Lys Gly Gly Gly Pro Pro Leu Thr Pro Val Pro Glu Phe 
225                 230                 235                 240 


Cys Thr Asn Asp Val Asp Phe Tyr Cys Ala Thr Thr Phe His Ser Phe 
                245                 250                 255     


Leu Pro Leu Cys Arg Lys Pro Val Lys Lys Lys Asp Ile Phe Val Ala 
            260                 265                 270         


Val Lys Thr Cys Lys Lys Phe His Gly Asp Arg Ile Pro Ile Val Lys 
        275                 280                 285             


Gln Thr Trp Glu Ser Gln Ala Ser Leu Ile Glu Tyr Tyr Ser Asp Tyr 
    290                 295                 300                 


Thr Glu Asn Ser Ile Pro Thr Val Asp Leu Gly Ile Pro Asn Thr Asp 
305                 310                 315                 320 


Arg Gly His Cys Gly Lys Thr Phe Ala Ile Leu Glu Arg Phe Leu Asn 
                325                 330                 335     


Arg Ser Gln Asp Lys Thr Ala Trp Leu Val Ile Val Asp Asp Asp Thr 
            340                 345                 350         


Leu Ile Ser Ile Ser Arg Leu Gln His Leu Leu Ser Cys Tyr Asp Ser 
        355                 360                 365             


Gly Glu Pro Val Phe Leu Gly Glu Arg Tyr Gly Tyr Gly Leu Gly Thr 
    370                 375                 380                 


Gly Gly Tyr Ser Tyr Ile Thr Gly Gly Gly Gly Met Val Phe Ser Arg 
385                 390                 395                 400 


Glu Ala Val Arg Arg Leu Leu Ala Ser Lys Cys Arg Cys Tyr Ser Asn 
                405                 410                 415     


Asp Ala Pro Asp Asp Met Val Leu Gly Met Cys Phe Ser Gly Leu Gly 
            420                 425                 430         


Ile Pro Val Thr His Ser Pro Leu Phe His Gln Ala Arg Pro Val Asp 
        435                 440                 445             


Tyr Pro Lys Asp Tyr Leu Ser His Gln Val Pro Ile Ser Phe His Lys 
    450                 455                 460                 


His Trp Asn Ile Asp Pro Val Lys Val Tyr Phe Thr Trp Leu Ala Pro 
465                 470                 475                 480 


Ser Asp Glu Asp Lys Ala Arg Gln Glu Thr Gln Lys Gly Phe Arg Glu 
                485                 490                 495     


Glu Leu 
        


<210>  1332
<211>  127
<212>  PRT
<213>  Homo Sapiens

<400>  1332

Met Lys Tyr Leu Arg His Arg Arg Pro Asn Ala Thr Leu Ile Leu Ala 
1               5                   10                  15      


Ile Gly Ala Phe Thr Leu Leu Leu Phe Ser Leu Leu Val Ser Pro Pro 
            20                  25                  30          


Thr Cys Lys Val Gln Glu Gln Pro Pro Ala Ile Pro Glu Ala Leu Ala 
        35                  40                  45              


Trp Pro Thr Pro Pro Thr Arg Pro Ala Pro Ala Pro Cys His Ala Asn 
    50                  55                  60                  


Thr Ser Met Val Thr His Pro Asp Phe Ala Thr Gln Pro Gln His Val 
65                  70                  75                  80  


Gln Asn Phe Leu Leu Tyr Arg His Cys Arg His Phe Pro Leu Leu Gln 
                85                  90                  95      


Asp Val Pro Pro Ser Lys Cys Ala Gln Pro Val Phe Leu Leu Leu Val 
            100                 105                 110         


Ile Lys Ser Ser Pro Ser Asn Tyr Val Arg Arg Glu Leu Leu Arg 
        115                 120                 125         


<210>  1333
<211>  250
<212>  PRT
<213>  Homo Sapiens

<400>  1333

Met Lys Tyr Leu Arg His Arg Arg Pro Asn Ala Thr Leu Ile Leu Ala 
1               5                   10                  15      


Ile Gly Ala Phe Thr Leu Leu Leu Phe Ser Leu Leu Val Ser Pro Pro 
            20                  25                  30          


Thr Cys Lys Val Gln Glu Gln Pro Pro Ala Ile Pro Glu Ala Leu Ala 
        35                  40                  45              


Trp Pro Thr Pro Pro Thr Arg Pro Ala Pro Ala Pro Cys His Ala Asn 
    50                  55                  60                  


Thr Ser Met Val Thr His Pro Asp Phe Ala Thr Gln Pro Gln His Val 
65                  70                  75                  80  


Gln Asn Phe Leu Leu Tyr Arg His Cys Arg His Phe Pro Leu Leu Gln 
                85                  90                  95      


Asp Val Pro Pro Ser Lys Cys Ala Gln Pro Val Phe Leu Leu Leu Val 
            100                 105                 110         


Ile Lys Ser Ser Pro Ser Asn Tyr Val Arg Arg Glu Leu Leu Arg Arg 
        115                 120                 125             


Thr Trp Gly Arg Glu Arg Lys Val Arg Gly Leu Gln Leu Arg Leu Leu 
    130                 135                 140                 


Phe Leu Val Gly Thr Ala Ser Asn Pro His Glu Ala Arg Lys Val Asn 
145                 150                 155                 160 


Arg Leu Leu Glu Leu Glu Ala Gln Thr His Gly Asp Ile Leu Gln Trp 
                165                 170                 175     


Asp Phe His Asp Ser Phe Phe Asn Leu Thr Leu Lys Gln Val Leu Phe 
            180                 185                 190         


Leu Gln Trp Gln Glu Thr Arg Cys Ala Asn Ala Ser Phe Val Leu Asn 
        195                 200                 205             


Gly Asp Asp Asp Val Phe Ala His Thr Asp Asn Met Val Phe Tyr Leu 
    210                 215                 220                 


Gln Asp His Asp Pro Gly Arg His Leu Phe Val Gly Gln Leu Ile Gln 
225                 230                 235                 240 


Asn Val Gly Pro Ile Arg Ala Phe Trp Ser 
                245                 250 


<210>  1334
<211>  372
<212>  PRT
<213>  Homo Sapiens

<400>  1334

Met Lys Tyr Leu Arg His Arg Arg Pro Asn Ala Thr Leu Ile Leu Ala 
1               5                   10                  15      


Ile Gly Ala Phe Thr Leu Leu Leu Phe Ser Leu Leu Val Ser Pro Pro 
            20                  25                  30          


Thr Cys Lys Val Gln Glu Gln Pro Pro Ala Ile Pro Glu Ala Leu Ala 
        35                  40                  45              


Trp Pro Thr Pro Pro Thr Arg Pro Ala Pro Ala Pro Cys His Ala Asn 
    50                  55                  60                  


Thr Ser Met Val Thr His Pro Asp Phe Ala Thr Gln Pro Gln His Val 
65                  70                  75                  80  


Gln Asn Phe Leu Leu Tyr Arg His Cys Arg His Phe Pro Leu Leu Gln 
                85                  90                  95      


Asp Val Pro Pro Ser Lys Cys Ala Gln Pro Val Phe Leu Leu Leu Val 
            100                 105                 110         


Ile Lys Ser Ser Pro Ser Asn Tyr Val Arg Arg Glu Leu Leu Arg Arg 
        115                 120                 125             


Thr Trp Gly Arg Glu Arg Lys Val Arg Gly Leu Gln Leu Arg Leu Leu 
    130                 135                 140                 


Phe Leu Val Gly Thr Ala Ser Asn Pro His Glu Ala Arg Lys Val Asn 
145                 150                 155                 160 


Arg Leu Leu Glu Leu Glu Ala Gln Thr His Gly Asp Ile Leu Gln Trp 
                165                 170                 175     


Asp Phe His Asp Ser Phe Phe Asn Leu Thr Leu Lys Gln Val Leu Phe 
            180                 185                 190         


Leu Gln Trp Gln Glu Thr Arg Cys Ala Asn Ala Ser Phe Val Leu Asn 
        195                 200                 205             


Gly Asp Asp Asp Val Phe Ala His Thr Asp Asn Met Val Phe Tyr Leu 
    210                 215                 220                 


Gln Asp His Asp Pro Gly Arg His Leu Phe Val Gly Gln Leu Ile Gln 
225                 230                 235                 240 


Asn Val Gly Pro Ile Arg Ala Phe Trp Ser Lys Tyr Tyr Val Pro Glu 
                245                 250                 255     


Val Val Thr Gln Asn Glu Arg Tyr Pro Pro Tyr Cys Gly Gly Gly Gly 
            260                 265                 270         


Phe Leu Leu Ser Arg Phe Thr Ala Ala Ala Leu Arg Arg Ala Ala His 
        275                 280                 285             


Val Leu Asp Ile Phe Pro Ile Asp Asp Val Phe Leu Gly Met Cys Leu 
    290                 295                 300                 


Glu Leu Glu Gly Leu Lys Pro Ala Ser His Ser Gly Ile Arg Thr Ser 
305                 310                 315                 320 


Gly Val Arg Ala Pro Ser Gln Arg Leu Ser Ser Phe Asp Pro Cys Phe 
                325                 330                 335     


Tyr Arg Asp Leu Leu Leu Val His Arg Phe Leu Pro Tyr Glu Met Leu 
            340                 345                 350         


Leu Met Trp Asp Ala Leu Asn Gln Pro Asn Leu Thr Cys Gly Asn Gln 
        355                 360                 365             


Thr Gln Ile Tyr 
    370         


<210>  1335
<211>  372
<212>  PRT
<213>  Homo Sapiens

<400>  1335

Met Lys Tyr Leu Arg His Arg Arg Pro Asn Ala Thr Leu Ile Leu Ala 
1               5                   10                  15      


Ile Gly Ala Phe Thr Leu Leu Leu Phe Ser Leu Leu Val Ser Pro Pro 
            20                  25                  30          


Thr Cys Lys Val Gln Glu Gln Pro Pro Ala Ile Pro Glu Ala Leu Ala 
        35                  40                  45              


Trp Pro Thr Pro Pro Thr Arg Pro Ala Pro Ala Pro Cys His Ala Asn 
    50                  55                  60                  


Thr Ser Met Val Thr His Pro Asp Phe Ala Thr Gln Pro Gln His Val 
65                  70                  75                  80  


Gln Asn Phe Leu Leu Tyr Arg His Cys Arg His Phe Pro Leu Leu Gln 
                85                  90                  95      


Asp Val Pro Pro Ser Lys Cys Ala Gln Pro Val Phe Leu Leu Leu Val 
            100                 105                 110         


Ile Lys Ser Ser Pro Ser Asn Tyr Val Arg Arg Glu Leu Leu Arg Arg 
        115                 120                 125             


Thr Trp Gly Arg Glu Arg Lys Val Arg Gly Leu Gln Leu Arg Leu Leu 
    130                 135                 140                 


Phe Leu Val Gly Thr Ala Ser Asn Pro His Glu Ala Arg Lys Val Asn 
145                 150                 155                 160 


Arg Leu Leu Glu Leu Glu Ala Gln Thr His Gly Asp Ile Leu Gln Trp 
                165                 170                 175     


Asp Phe His Asp Ser Phe Phe Asn Leu Thr Leu Lys Gln Val Leu Phe 
            180                 185                 190         


Leu Gln Trp Gln Glu Thr Arg Cys Ala Asn Ala Ser Phe Val Leu Asn 
        195                 200                 205             


Gly Asp Asp Asp Val Phe Ala His Thr Asp Asn Met Val Phe Tyr Leu 
    210                 215                 220                 


Gln Asp His Asp Pro Gly Arg His Leu Phe Val Gly Gln Leu Ile Gln 
225                 230                 235                 240 


Asn Val Gly Pro Ile Arg Ala Phe Trp Ser Lys Tyr Tyr Val Pro Glu 
                245                 250                 255     


Val Val Thr Gln Asn Glu Arg Tyr Pro Pro Tyr Cys Gly Gly Gly Gly 
            260                 265                 270         


Phe Leu Leu Ser Arg Phe Thr Ala Ala Ala Leu Arg Arg Ala Ala His 
        275                 280                 285             


Val Leu Asp Ile Phe Pro Ile Asp Asp Val Phe Leu Gly Met Cys Leu 
    290                 295                 300                 


Glu Leu Glu Gly Leu Lys Pro Ala Ser His Ser Gly Ile Arg Thr Ser 
305                 310                 315                 320 


Gly Val Arg Ala Pro Ser Gln Arg Leu Ser Ser Phe Asp Pro Cys Phe 
                325                 330                 335     


Tyr Arg Asp Leu Leu Leu Val His Arg Phe Leu Pro Tyr Glu Met Leu 
            340                 345                 350         


Leu Met Trp Asp Ala Leu Asn Gln Pro Asn Leu Thr Cys Gly Asn Gln 
        355                 360                 365             


Thr Gln Ile Tyr 
    370         


<210>  1336
<211>  353
<212>  PRT
<213>  Homo Sapiens

<400>  1336

Met Leu Cys Arg Leu Cys Trp Leu Val Ser Tyr Ser Leu Ala Val Leu 
1               5                   10                  15      


Leu Leu Gly Cys Leu Leu Phe Leu Arg Lys Ala Ala Lys Pro Ala Gly 
            20                  25                  30          


Asp Pro Thr Ala His Gln Pro Phe Trp Ala Pro Pro Thr Pro Arg His 
        35                  40                  45              


Ser Arg Cys Pro Pro Asn His Thr Val Ser Ser Ala Ser Leu Ser Leu 
    50                  55                  60                  


Pro Ser Arg His Arg Leu Phe Leu Thr Tyr Arg His Cys Arg Asn Phe 
65                  70                  75                  80  


Ser Ile Leu Leu Glu Pro Ser Gly Cys Ser Lys Asp Thr Phe Leu Leu 
                85                  90                  95      


Leu Ala Ile Lys Ser Gln Pro Gly His Val Glu Arg Arg Ala Ala Ile 
            100                 105                 110         


Arg Ser Thr Trp Gly Arg Val Gly Gly Trp Ala Arg Gly Arg Gln Leu 
        115                 120                 125             


Lys Leu Val Phe Leu Leu Gly Val Ala Gly Ser Ala Pro Pro Ala Gln 
    130                 135                 140                 


Leu Leu Ala Tyr Glu Ser Arg Glu Phe Asp Asp Ile Leu Gln Trp Asp 
145                 150                 155                 160 


Phe Thr Glu Asp Phe Phe Asn Leu Thr Leu Lys Glu Leu His Leu Gln 
                165                 170                 175     


Arg Trp Val Val Ala Ala Cys Pro Gln Ala His Phe Met Leu Lys Gly 
            180                 185                 190         


Asp Asp Asp Val Phe Val His Val Pro Asn Val Leu Glu Phe Leu Asp 
        195                 200                 205             


Gly Trp Asp Pro Ala Gln Asp Leu Leu Val Gly Asp Val Ile Arg Gln 
    210                 215                 220                 


Ala Leu Pro Asn Arg Asn Thr Lys Val Lys Tyr Phe Ile Pro Pro Ser 
225                 230                 235                 240 


Met Tyr Arg Ala Thr His Tyr Pro Pro Tyr Ala Gly Gly Gly Gly Tyr 
                245                 250                 255     


Val Met Ser Arg Ala Thr Val Arg Arg Leu Gln Ala Ile Met Glu Asp 
            260                 265                 270         


Ala Glu Leu Phe Pro Ile Asp Asp Val Phe Val Gly Met Cys Leu Arg 
        275                 280                 285             


Arg Leu Gly Leu Ser Pro Met His His Ala Gly Phe Lys Thr Phe Gly 
    290                 295                 300                 


Ile Arg Arg Pro Leu Asp Pro Leu Asp Pro Cys Leu Tyr Arg Gly Leu 
305                 310                 315                 320 


Leu Leu Val His Arg Leu Ser Pro Leu Glu Met Trp Thr Met Trp Ala 
                325                 330                 335     


Leu Val Thr Asp Glu Gly Leu Lys Cys Ala Ala Gly Pro Ile Pro Gln 
            340                 345                 350         


Arg 
    


<210>  1337
<211>  353
<212>  PRT
<213>  Homo Sapiens

<400>  1337

Met Leu Cys Arg Leu Cys Trp Leu Val Ser Tyr Ser Leu Ala Val Leu 
1               5                   10                  15      


Leu Leu Gly Cys Leu Leu Phe Leu Arg Lys Ala Ala Lys Pro Ala Gly 
            20                  25                  30          


Asp Pro Thr Ala His Gln Pro Phe Trp Ala Pro Pro Thr Pro Arg His 
        35                  40                  45              


Ser Arg Cys Pro Pro Asn His Thr Val Ser Ser Ala Ser Leu Ser Leu 
    50                  55                  60                  


Pro Ser Arg His Arg Leu Phe Leu Thr Tyr Arg His Cys Arg Asn Phe 
65                  70                  75                  80  


Ser Ile Leu Leu Glu Pro Ser Gly Cys Ser Lys Asp Thr Phe Leu Leu 
                85                  90                  95      


Leu Ala Ile Lys Ser Gln Pro Gly His Val Glu Arg Arg Ala Ala Ile 
            100                 105                 110         


Arg Ser Thr Trp Gly Arg Val Gly Gly Trp Ala Arg Gly Arg Gln Leu 
        115                 120                 125             


Lys Leu Val Phe Leu Leu Gly Val Ala Gly Ser Ala Pro Pro Ala Gln 
    130                 135                 140                 


Leu Leu Ala Tyr Glu Ser Arg Glu Phe Asp Asp Ile Leu Gln Trp Asp 
145                 150                 155                 160 


Phe Thr Glu Asp Phe Phe Asn Leu Thr Leu Lys Glu Leu His Leu Gln 
                165                 170                 175     


Arg Trp Val Val Ala Ala Cys Pro Gln Ala His Phe Met Leu Lys Gly 
            180                 185                 190         


Asp Asp Asp Val Phe Val His Val Pro Asn Val Leu Glu Phe Leu Asp 
        195                 200                 205             


Gly Trp Asp Pro Ala Gln Asp Leu Leu Val Gly Asp Val Ile Arg Gln 
    210                 215                 220                 


Ala Leu Pro Asn Arg Asn Thr Lys Val Lys Tyr Phe Ile Pro Pro Ser 
225                 230                 235                 240 


Met Tyr Arg Ala Thr His Tyr Pro Pro Tyr Ala Gly Gly Gly Gly Tyr 
                245                 250                 255     


Val Met Ser Arg Ala Thr Val Arg Arg Leu Gln Ala Ile Met Glu Asp 
            260                 265                 270         


Ala Glu Leu Phe Pro Ile Asp Asp Val Phe Val Gly Met Cys Leu Arg 
        275                 280                 285             


Arg Leu Gly Leu Ser Pro Met His His Ala Gly Phe Lys Thr Phe Gly 
    290                 295                 300                 


Ile Arg Arg Pro Leu Asp Pro Leu Asp Pro Cys Leu Tyr Arg Gly Leu 
305                 310                 315                 320 


Leu Leu Val His Arg Leu Ser Pro Leu Glu Met Trp Thr Met Trp Ala 
                325                 330                 335     


Leu Val Thr Asp Glu Gly Leu Lys Cys Ala Ala Gly Pro Ile Pro Gln 
            340                 345                 350         


Arg 
    


<210>  1338
<211>  378
<212>  PRT
<213>  Homo Sapiens

<400>  1338

Met Leu Pro Pro Gln Pro Ser Ala Ala His Gln Gly Arg Gly Gly Arg 
1               5                   10                  15      


Ser Gly Leu Leu Pro Lys Gly Pro Ala Met Leu Cys Arg Leu Cys Trp 
            20                  25                  30          


Leu Val Ser Tyr Ser Leu Ala Val Leu Leu Leu Gly Cys Leu Leu Phe 
        35                  40                  45              


Leu Arg Lys Ala Ala Lys Pro Ala Gly Asp Pro Thr Ala His Gln Pro 
    50                  55                  60                  


Phe Trp Ala Pro Pro Thr Pro Arg His Ser Arg Cys Pro Pro Asn His 
65                  70                  75                  80  


Thr Val Ser Ser Ala Ser Leu Ser Leu Pro Ser Arg His Arg Leu Phe 
                85                  90                  95      


Leu Thr Tyr Arg His Cys Arg Asn Phe Ser Ile Leu Leu Glu Pro Ser 
            100                 105                 110         


Gly Cys Ser Lys Asp Thr Phe Leu Leu Leu Ala Ile Lys Ser Gln Pro 
        115                 120                 125             


Gly His Val Glu Arg Arg Ala Ala Ile Arg Ser Thr Trp Gly Arg Val 
    130                 135                 140                 


Gly Gly Trp Ala Arg Gly Arg Gln Leu Lys Leu Val Phe Leu Leu Gly 
145                 150                 155                 160 


Val Ala Gly Ser Ala Pro Pro Ala Gln Leu Leu Ala Tyr Glu Ser Arg 
                165                 170                 175     


Glu Phe Asp Asp Ile Leu Gln Trp Asp Phe Thr Glu Asp Phe Phe Asn 
            180                 185                 190         


Leu Thr Leu Lys Glu Leu His Leu Gln Arg Trp Val Val Ala Ala Cys 
        195                 200                 205             


Pro Gln Ala His Phe Met Leu Lys Gly Asp Asp Asp Val Phe Val His 
    210                 215                 220                 


Val Pro Asn Val Leu Glu Phe Leu Asp Gly Trp Asp Pro Ala Gln Asp 
225                 230                 235                 240 


Leu Leu Val Gly Asp Val Ile Arg Gln Ala Leu Pro Asn Arg Asn Thr 
                245                 250                 255     


Lys Val Lys Tyr Phe Ile Pro Pro Ser Met Tyr Arg Ala Thr His Tyr 
            260                 265                 270         


Pro Pro Tyr Ala Gly Gly Gly Gly Tyr Val Met Ser Arg Ala Thr Val 
        275                 280                 285             


Arg Arg Leu Gln Ala Ile Met Glu Asp Ala Glu Leu Phe Pro Ile Asp 
    290                 295                 300                 


Asp Val Phe Val Gly Met Cys Leu Arg Arg Leu Gly Leu Ser Pro Met 
305                 310                 315                 320 


His His Ala Gly Phe Lys Thr Phe Gly Ile Arg Arg Pro Leu Asp Pro 
                325                 330                 335     


Leu Asp Pro Cys Leu Tyr Arg Gly Leu Leu Leu Val His Arg Leu Ser 
            340                 345                 350         


Pro Leu Glu Met Trp Thr Met Trp Ala Leu Val Thr Asp Glu Gly Leu 
        355                 360                 365             


Lys Cys Ala Ala Gly Pro Ile Pro Gln Arg 
    370                 375             


<210>  1339
<211>  55
<212>  PRT
<213>  Homo Sapiens

<400>  1339

Met Leu Pro Pro Gln Pro Ser Ala Ala His Gln Gly Arg Gly Gly Arg 
1               5                   10                  15      


Ser Gly Leu Leu Pro Lys Gly Trp Gln Asp Pro Leu Pro Gln Pro Ser 
            20                  25                  30          


Cys Trp Pro Met Arg Val Gly Ser Leu Met Thr Ser Ser Ser Gly Thr 
        35                  40                  45              


Ser Leu Arg Thr Ser Ser Thr 
    50                  55  


<210>  1340
<211>  121
<212>  PRT
<213>  Homo Sapiens

<400>  1340

Met Ala Phe Pro Cys Arg Arg Ser Leu Thr Ala Lys Thr Leu Ala Cys 
1               5                   10                  15      


Leu Leu Val Gly Val Ser Phe Leu Ala Leu Gln Gln Trp Phe Leu Gln 
            20                  25                  30          


Ala Pro Arg Ser Pro Arg Glu Glu Arg Ser Pro Gln Glu Glu Thr Pro 
        35                  40                  45              


Glu Gly Pro Thr Asp Ala Pro Ala Ala Asp Glu Pro Pro Ser Glu Leu 
    50                  55                  60                  


Val Pro Gly Pro Pro Cys Val Ala Asn Ala Ser Ala Asn Ala Thr Ala 
65                  70                  75                  80  


Asp Phe Glu Gln Leu Pro Ala Arg Ile Gln Asp Phe Leu Arg Tyr Arg 
                85                  90                  95      


His Cys Arg His Phe Pro Leu Leu Trp Asp Ala Pro Ala Lys Cys Ala 
            100                 105                 110         


Gly Gly Arg Gly Val Phe Leu Leu Leu 
        115                 120     


<210>  1341
<211>  384
<212>  PRT
<213>  Homo Sapiens

<400>  1341

Met Ala Phe Pro Cys Arg Arg Ser Leu Thr Ala Lys Thr Leu Ala Cys 
1               5                   10                  15      


Leu Leu Val Gly Val Ser Phe Leu Ala Leu Gln Gln Trp Phe Leu Gln 
            20                  25                  30          


Ala Pro Arg Ser Pro Arg Glu Glu Arg Ser Pro Gln Glu Glu Thr Pro 
        35                  40                  45              


Glu Gly Pro Thr Asp Ala Pro Ala Ala Asp Glu Pro Pro Ser Glu Leu 
    50                  55                  60                  


Val Pro Gly Pro Pro Cys Val Ala Asn Ala Ser Ala Asn Ala Thr Ala 
65                  70                  75                  80  


Asp Phe Glu Gln Leu Pro Ala Arg Ile Gln Asp Phe Leu Arg Tyr Arg 
                85                  90                  95      


His Cys Arg His Phe Pro Leu Leu Trp Asp Ala Pro Ala Lys Cys Ala 
            100                 105                 110         


Gly Gly Arg Gly Val Phe Leu Leu Leu Ala Val Lys Ser Ala Pro Glu 
        115                 120                 125             


His Tyr Glu Arg Arg Glu Leu Ile Arg Arg Thr Trp Gly Gln Glu Arg 
    130                 135                 140                 


Ser Tyr Gly Gly Arg Pro Val Arg Arg Leu Phe Leu Leu Gly Thr Pro 
145                 150                 155                 160 


Gly Pro Glu Asp Glu Ala Arg Ala Glu Arg Leu Ala Glu Leu Val Ala 
                165                 170                 175     


Leu Glu Ala Arg Glu His Gly Asp Val Leu Gln Trp Ala Phe Ala Asp 
            180                 185                 190         


Thr Phe Leu Asn Leu Thr Leu Lys His Leu His Leu Leu Asp Trp Leu 
        195                 200                 205             


Ala Ala Arg Cys Pro His Ala Arg Phe Leu Leu Ser Gly Asp Asp Asp 
    210                 215                 220                 


Val Phe Val His Thr Ala Asn Val Val Arg Phe Leu Gln Ala Gln Pro 
225                 230                 235                 240 


Pro Gly Arg His Leu Phe Ser Gly Gln Leu Met Glu Gly Ser Val Pro 
                245                 250                 255     


Ile Arg Asp Ser Trp Ser Lys Tyr Phe Val Pro Pro Gln Leu Phe Pro 
            260                 265                 270         


Gly Ser Ala Tyr Pro Val Tyr Cys Ser Gly Gly Gly Phe Leu Leu Ser 
        275                 280                 285             


Gly Pro Thr Ala Arg Ala Leu Arg Ala Ala Ala Arg His Thr Pro Leu 
    290                 295                 300                 


Phe Pro Ile Asp Asp Ala Tyr Met Gly Met Cys Leu Glu Arg Ala Gly 
305                 310                 315                 320 


Leu Ala Pro Ser Gly His Glu Gly Ile Arg Pro Phe Gly Val Gln Leu 
                325                 330                 335     


Pro Gly Ala Gln Gln Ser Ser Phe Asp Pro Cys Met Tyr Arg Glu Leu 
            340                 345                 350         


Leu Leu Val His Arg Phe Ala Pro Tyr Glu Met Leu Leu Met Trp Lys 
        355                 360                 365             


Ala Leu His Ser Pro Ala Leu Ser Cys Asp Arg Gly His Arg Val Ser 
    370                 375                 380                 


<210>  1342
<211>  401
<212>  PRT
<213>  Homo Sapiens

<400>  1342

Met Ser Leu Trp Lys Lys Thr Val Tyr Arg Ser Leu Cys Leu Ala Leu 
1               5                   10                  15      


Ala Leu Leu Val Ala Val Thr Val Phe Gln Arg Ser Leu Thr Pro Gly 
            20                  25                  30          


Gln Phe Leu Gln Glu Pro Pro Pro Pro Thr Leu Glu Pro Gln Lys Ala 
        35                  40                  45              


Gln Lys Pro Asn Gly Gln Leu Val Asn Pro Asn Asn Phe Trp Lys Asn 
    50                  55                  60                  


Pro Lys Asp Val Ala Ala Pro Thr Pro Met Ala Ser Gln Gly Pro Gln 
65                  70                  75                  80  


Ala Trp Asp Val Thr Thr Thr Asn Cys Ser Ala Asn Ile Asn Leu Thr 
                85                  90                  95      


His Gln Pro Trp Phe Gln Val Leu Glu Pro Gln Phe Arg Gln Phe Leu 
            100                 105                 110         


Phe Tyr Arg His Cys Arg Tyr Phe Pro Met Leu Leu Asn His Pro Glu 
        115                 120                 125             


Lys Cys Arg Gly Asp Val Tyr Leu Leu Val Val Val Lys Ser Val Ile 
    130                 135                 140                 


Thr Gln His Asp Arg Arg Glu Ala Ile Arg Gln Thr Trp Gly Arg Glu 
145                 150                 155                 160 


Arg Gln Ser Ala Gly Gly Gly Arg Gly Ala Val Arg Thr Leu Phe Leu 
                165                 170                 175     


Leu Gly Thr Ala Ser Lys Gln Glu Glu Arg Thr His Tyr Gln Gln Leu 
            180                 185                 190         


Leu Ala Tyr Glu Asp Arg Leu Tyr Gly Asp Ile Leu Gln Trp Gly Phe 
        195                 200                 205             


Leu Asp Thr Phe Phe Asn Leu Thr Leu Lys Glu Ile His Phe Leu Lys 
    210                 215                 220                 


Trp Leu Asp Ile Tyr Cys Pro His Val Pro Phe Ile Phe Lys Gly Asp 
225                 230                 235                 240 


Asp Asp Val Phe Val Asn Pro Thr Asn Leu Leu Glu Phe Leu Ala Asp 
                245                 250                 255     


Arg Gln Pro Gln Glu Asn Leu Phe Val Gly Asp Val Leu Gln His Ala 
            260                 265                 270         


Arg Pro Ile Arg Arg Lys Asp Asn Lys Tyr Tyr Ile Pro Gly Ala Leu 
        275                 280                 285             


Tyr Gly Lys Ala Ser Tyr Pro Pro Tyr Ala Gly Gly Gly Gly Phe Leu 
    290                 295                 300                 


Met Ala Gly Ser Leu Ala Arg Arg Leu His His Ala Cys Asp Thr Leu 
305                 310                 315                 320 


Glu Leu Tyr Pro Ile Asp Asp Val Phe Leu Gly Met Cys Leu Glu Val 
                325                 330                 335     


Leu Gly Val Gln Pro Thr Ala His Glu Gly Phe Lys Thr Phe Gly Ile 
            340                 345                 350         


Ser Arg Asn Arg Asn Ser Arg Met Asn Lys Glu Pro Cys Phe Phe Arg 
        355                 360                 365             


Ala Met Leu Val Val His Lys Leu Leu Pro Pro Glu Leu Leu Ala Met 
    370                 375                 380                 


Trp Gly Leu Val His Ser Asn Leu Thr Cys Ser Arg Lys Leu Gln Val 
385                 390                 395                 400 


Leu 
    


<210>  1343
<211>  397
<212>  PRT
<213>  Homo Sapiens

<400>  1343

Met Arg Cys Pro Lys Cys Leu Leu Cys Leu Ser Ala Leu Leu Thr Leu 
1               5                   10                  15      


Leu Gly Leu Lys Val Tyr Ile Glu Trp Thr Ser Glu Ser Arg Leu Ser 
            20                  25                  30          


Lys Ala Tyr Pro Ser Pro Arg Gly Thr Pro Pro Ser Pro Thr Pro Ala 
        35                  40                  45              


Asn Pro Glu Pro Thr Leu Pro Ala Asn Leu Ser Thr Arg Leu Gly Gln 
    50                  55                  60                  


Thr Ile Pro Leu Pro Phe Ala Tyr Trp Asn Gln Gln Gln Trp Arg Leu 
65                  70                  75                  80  


Gly Ser Leu Pro Ser Gly Asp Ser Thr Glu Thr Gly Gly Cys Gln Ala 
                85                  90                  95      


Trp Gly Ala Ala Ala Ala Thr Glu Ile Pro Asp Phe Ala Ser Tyr Pro 
            100                 105                 110         


Lys Asp Leu Arg Arg Phe Leu Leu Ser Ala Ala Cys Arg Ser Phe Pro 
        115                 120                 125             


Gln Trp Leu Pro Gly Gly Gly Gly Ser Gln Val Ser Ser Cys Ser Asp 
    130                 135                 140                 


Thr Asp Val Pro Tyr Leu Leu Leu Ala Val Lys Ser Glu Pro Gly Arg 
145                 150                 155                 160 


Phe Ala Glu Arg Gln Ala Val Arg Glu Thr Trp Gly Ser Pro Ala Pro 
                165                 170                 175     


Gly Ile Arg Leu Leu Phe Leu Leu Gly Ser Pro Val Gly Glu Ala Gly 
            180                 185                 190         


Pro Asp Leu Asp Ser Leu Val Ala Trp Glu Ser Arg Arg Tyr Ser Asp 
        195                 200                 205             


Leu Leu Leu Trp Asp Phe Leu Asp Val Pro Phe Asn Gln Thr Leu Lys 
    210                 215                 220                 


Asp Leu Leu Leu Leu Ala Trp Leu Gly Arg His Cys Pro Thr Val Ser 
225                 230                 235                 240 


Phe Val Leu Arg Ala Gln Asp Asp Ala Phe Val His Thr Pro Ala Leu 
                245                 250                 255     


Leu Ala His Leu Arg Ala Leu Pro Pro Ala Ser Ala Arg Ser Leu Tyr 
            260                 265                 270         


Leu Gly Glu Val Phe Thr Gln Ala Met Pro Leu Arg Lys Pro Gly Gly 
        275                 280                 285             


Pro Phe Tyr Val Pro Glu Ser Phe Phe Glu Gly Gly Tyr Pro Ala Tyr 
    290                 295                 300                 


Ala Ser Gly Gly Gly Tyr Val Ile Ala Gly Arg Leu Ala Pro Trp Leu 
305                 310                 315                 320 


Leu Arg Ala Ala Ala Arg Val Ala Pro Phe Pro Phe Glu Asp Val Tyr 
                325                 330                 335     


Thr Gly Leu Cys Ile Arg Ala Leu Gly Leu Val Pro Gln Ala His Pro 
            340                 345                 350         


Gly Phe Leu Thr Ala Trp Pro Ala Asp Arg Thr Ala Asp His Cys Ala 
        355                 360                 365             


Phe Arg Asn Leu Leu Leu Val Arg Pro Leu Gly Pro Gln Ala Ser Ile 
    370                 375                 380                 


Arg Leu Trp Lys Gln Leu Gln Asp Pro Arg Leu Gln Cys 
385                 390                 395         


<210>  1344
<211>  402
<212>  PRT
<213>  Homo Sapiens

<400>  1344

Met Arg Arg Arg Leu Arg Leu Arg Arg Asp Ala Leu Leu Thr Leu Leu 
1               5                   10                  15      


Leu Gly Ala Ser Leu Gly Leu Leu Leu Tyr Ala Gln Arg Asp Gly Ala 
            20                  25                  30          


Ala Pro Thr Ala Ser Ala Pro Arg Gly Arg Gly Arg Ala Ala Pro Arg 
        35                  40                  45              


Pro Thr Pro Gly Pro Arg Ala Phe Gln Leu Pro Asp Ala Gly Ala Ala 
    50                  55                  60                  


Pro Pro Ala Tyr Glu Gly Asp Thr Pro Ala Pro Pro Thr Pro Thr Gly 
65                  70                  75                  80  


Pro Phe Asp Phe Ala Arg Tyr Leu Arg Ala Lys Asp Gln Arg Arg Phe 
                85                  90                  95      


Pro Leu Leu Ile Asn Gln Pro His Lys Cys Arg Gly Asp Gly Ala Pro 
            100                 105                 110         


Gly Gly Arg Pro Asp Leu Leu Ile Ala Val Lys Ser Val Ala Glu Asp 
        115                 120                 125             


Phe Glu Arg Arg Gln Ala Val Arg Gln Thr Trp Gly Ala Glu Gly Arg 
    130                 135                 140                 


Val Gln Gly Ala Leu Val Arg Arg Val Phe Leu Leu Gly Val Pro Arg 
145                 150                 155                 160 


Gly Ala Gly Ser Gly Gly Ala Asp Glu Val Gly Glu Gly Ala Arg Thr 
                165                 170                 175     


His Trp Arg Ala Leu Leu Arg Ala Glu Ser Leu Ala Tyr Ala Asp Ile 
            180                 185                 190         


Leu Leu Trp Ala Phe Asp Asp Thr Phe Phe Asn Leu Thr Leu Lys Glu 
        195                 200                 205             


Ile His Phe Leu Ala Trp Ala Ser Ala Phe Cys Pro Asp Val Arg Phe 
    210                 215                 220                 


Val Phe Lys Gly Asp Ala Asp Val Phe Val Asn Val Gly Asn Leu Leu 
225                 230                 235                 240 


Glu Phe Leu Ala Pro Arg Asp Pro Ala Gln Asp Leu Leu Ala Gly Asp 
                245                 250                 255     


Val Ile Val His Ala Arg Pro Ile Arg Thr Arg Ala Ser Lys Tyr Tyr 
            260                 265                 270         


Ile Pro Glu Ala Val Tyr Gly Leu Pro Ala Tyr Pro Ala Tyr Ala Gly 
        275                 280                 285             


Gly Gly Gly Phe Val Leu Ser Gly Ala Thr Leu His Arg Leu Ala Gly 
    290                 295                 300                 


Ala Cys Ala Gln Val Glu Leu Phe Pro Ile Asp Asp Val Phe Leu Gly 
305                 310                 315                 320 


Met Cys Leu Gln Arg Leu Arg Leu Thr Pro Glu Pro His Pro Ala Phe 
                325                 330                 335     


Arg Thr Phe Gly Ile Pro Gln Pro Ser Ala Ala Pro His Leu Ser Thr 
            340                 345                 350         


Phe Asp Pro Cys Phe Tyr Arg Glu Leu Val Val Val His Gly Leu Ser 
        355                 360                 365             


Ala Ala Asp Ile Trp Leu Met Trp Arg Leu Leu His Gly Pro His Gly 
    370                 375                 380                 


Pro Ala Cys Ala His Pro Gln Pro Val Ala Ala Gly Pro Phe Gln Trp 
385                 390                 395                 400 


Asp Ser 
        


<210>  1345
<211>  96
<212>  PRT
<213>  Homo Sapiens

<400>  1345

Met Trp Leu Gly Arg Arg Ala Leu Cys Ala Leu Val Leu Leu Leu Ala 
1               5                   10                  15      


Cys Ala Ser Leu Gly Leu Leu Tyr Ala Ser Thr Arg Asp Ala Pro Gly 
            20                  25                  30          


Leu Arg Leu Pro Leu Ala Pro Trp Ala Pro Pro Gln Ser Pro Arg Arg 
        35                  40                  45              


Pro Glu Leu Pro Asp Leu Ala Pro Glu Pro Arg Tyr Ala His Ile Pro 
    50                  55                  60                  


Val Arg Ile Lys Glu Gln Val Val Gly Ala Glu Gly Cys Leu Cys His 
65                  70                  75                  80  


Lys Arg Ala Gly Val Pro Gly Leu Ser Val Glu Glu Pro Val Pro Ser 
                85                  90                  95      


<210>  1346
<211>  81
<212>  PRT
<213>  Homo Sapiens

<400>  1346

Met Trp Leu Gly Arg Arg Ala Leu Cys Ala Leu Val Leu Leu Leu Ala 
1               5                   10                  15      


Cys Ala Ser Leu Gly Leu Leu Tyr Ala Ser Thr Arg Asp Ala Pro Gly 
            20                  25                  30          


Leu Arg Leu Pro Leu Ala Pro Trp Ala Pro Pro Gln Ser Pro Arg Arg 
        35                  40                  45              


Pro Glu Leu Pro Asp Leu Ala Pro Glu Pro Arg Tyr Ala His Ile Pro 
    50                  55                  60                  


Val Arg Ile Lys Glu Gln Val Val Gly Leu Leu Ala Trp Asn Asn Cys 
65                  70                  75                  80  


Ser 
    


<210>  1347
<211>  120
<212>  PRT
<213>  Homo Sapiens

<400>  1347

Met Trp Leu Gly Arg Arg Ala Leu Cys Ala Leu Val Leu Leu Leu Ala 
1               5                   10                  15      


Cys Ala Ser Leu Gly Leu Leu Tyr Ala Ser Thr Arg Asp Ala Pro Gly 
            20                  25                  30          


Leu Arg Leu Pro Leu Ala Pro Trp Ala Pro Pro Gln Ser Pro Arg Arg 
        35                  40                  45              


Pro Glu Leu Pro Asp Leu Ala Pro Glu Pro Arg Tyr Ala His Ile Pro 
    50                  55                  60                  


Val Arg Ile Lys Glu Gln Val Val Gly Leu Leu Ala Trp Asn Asn Cys 
65                  70                  75                  80  


Ser Cys Glu Ser Ser Gly Gly Gly Leu Pro Leu Pro Phe Gln Lys Gln 
                85                  90                  95      


Val Arg Ala Ile Asp Leu Thr Lys Ala Phe Asp Pro Ala Glu Leu Arg 
            100                 105                 110         


Ala Ala Ser Ala Thr Arg Glu Gln 
        115                 120 


<210>  1348
<211>  231
<212>  PRT
<213>  Homo Sapiens

<400>  1348

Met Trp Leu Gly Arg Arg Ala Leu Cys Ala Leu Val Leu Leu Leu Ala 
1               5                   10                  15      


Cys Ala Ser Leu Gly Leu Leu Tyr Ala Ser Thr Arg Asp Ala Pro Gly 
            20                  25                  30          


Leu Arg Leu Pro Leu Ala Pro Trp Ala Pro Pro Gln Ser Pro Arg Arg 
        35                  40                  45              


Pro Glu Leu Pro Asp Leu Ala Pro Glu Pro Arg Tyr Ala His Ile Pro 
    50                  55                  60                  


Val Arg Ile Lys Glu Gln Val Val Gly Leu Leu Ala Trp Asn Asn Cys 
65                  70                  75                  80  


Ser Cys Glu Ser Ser Gly Gly Gly Leu Pro Leu Pro Phe Gln Lys Gln 
                85                  90                  95      


Val Arg Ala Ile Asp Leu Thr Lys Ala Phe Asp Pro Ala Glu Leu Arg 
            100                 105                 110         


Ala Ala Ser Ala Thr Arg Glu Gln Glu Phe Gln Ala Phe Leu Ser Arg 
        115                 120                 125             


Ser Gln Ser Pro Ala Asp Gln Leu Leu Ile Ala Pro Ala Asn Ser Pro 
    130                 135                 140                 


Leu Gln Tyr Pro Leu Gln Gly Val Glu Val Gln Pro Leu Arg Ser Ile 
145                 150                 155                 160 


Leu Val Pro Gly Glu Pro Asp Cys Leu Pro Arg His Leu Gly Arg Gly 
                165                 170                 175     


Arg Gly Ser Asp Trp Ser Tyr Ser His Trp Arg Gly Ser Gly Arg Ser 
            180                 185                 190         


His Pro Cys Gln Pro Arg Ala Gly Pro Thr Gln Gln Ala Thr Thr Thr 
        195                 200                 205             


Gly His Leu Gln Gln Pro Lys Leu Pro Asp Gln His Ser Arg His Ser 
    210                 215                 220                 


Pro Val Leu His Arg Gly Thr 
225                 230     


<210>  1349
<211>  237
<212>  PRT
<213>  Homo Sapiens

<400>  1349

Met Trp Leu Gly Arg Arg Ala Leu Cys Ala Leu Val Leu Leu Leu Ala 
1               5                   10                  15      


Cys Ala Ser Leu Gly Leu Leu Tyr Ala Ser Thr Arg Asp Ala Pro Gly 
            20                  25                  30          


Leu Arg Leu Pro Leu Ala Pro Trp Ala Pro Pro Gln Ser Pro Arg Arg 
        35                  40                  45              


Pro Glu Leu Pro Asp Leu Ala Pro Glu Pro Arg Tyr Ala His Ile Pro 
    50                  55                  60                  


Val Arg Ile Lys Glu Gln Val Val Gly Leu Leu Ala Trp Asn Asn Cys 
65                  70                  75                  80  


Ser Cys Glu Ser Ser Gly Gly Gly Leu Pro Leu Pro Phe Gln Lys Gln 
                85                  90                  95      


Val Arg Ala Ile Asp Leu Thr Lys Ala Phe Asp Pro Ala Glu Leu Arg 
            100                 105                 110         


Ala Ala Ser Ala Thr Arg Glu Gln Glu Phe Gln Ala Phe Leu Ser Arg 
        115                 120                 125             


Ser Gln Ser Pro Ala Asp Gln Leu Leu Ile Ala Pro Ala Asn Ser Pro 
    130                 135                 140                 


Leu Gln Tyr Pro Leu Gln Gly Val Glu Val Gln Pro Leu Arg Ser Ile 
145                 150                 155                 160 


Leu Val Pro Gly Leu Ser Leu Gln Ala Ala Ser Gly Gln Glu Val Tyr 
                165                 170                 175     


Gln Val Asn Leu Thr Ala Ser Leu Gly Thr Trp Asp Val Ala Gly Glu 
            180                 185                 190         


Val Thr Gly Val Thr Leu Thr Gly Glu Gly Gln Ala Asp Leu Thr Leu 
        195                 200                 205             


Val Ser Pro Gly Leu Asp Gln Leu Asn Arg Gln Leu Gln Leu Val Thr 
    210                 215                 220                 


Tyr Ser Ser Arg Ser Tyr Gln Thr Asn Thr Ala Asp Thr 
225                 230                 235         


<210>  1350
<211>  304
<212>  PRT
<213>  Homo Sapiens

<400>  1350

Met Trp Leu Gly Arg Arg Ala Leu Cys Ala Leu Val Leu Leu Leu Ala 
1               5                   10                  15      


Cys Ala Ser Leu Gly Leu Leu Tyr Ala Ser Thr Arg Asp Ala Pro Gly 
            20                  25                  30          


Leu Arg Leu Pro Leu Ala Pro Trp Ala Pro Pro Gln Ser Pro Arg Arg 
        35                  40                  45              


Pro Glu Leu Pro Asp Leu Ala Pro Glu Pro Arg Tyr Ala His Ile Pro 
    50                  55                  60                  


Val Arg Ile Lys Glu Gln Val Val Gly Leu Leu Ala Trp Asn Asn Cys 
65                  70                  75                  80  


Ser Cys Glu Ser Ser Gly Gly Gly Leu Pro Leu Pro Phe Gln Lys Gln 
                85                  90                  95      


Val Arg Ala Ile Asp Leu Thr Lys Ala Phe Asp Pro Ala Glu Leu Arg 
            100                 105                 110         


Ala Ala Ser Ala Thr Arg Glu Gln Glu Phe Gln Ala Phe Leu Ser Arg 
        115                 120                 125             


Ser Gln Ser Pro Ala Asp Gln Leu Leu Ile Ala Pro Ala Asn Ser Pro 
    130                 135                 140                 


Leu Gln Tyr Pro Leu Gln Gly Val Glu Val Gln Pro Leu Arg Ser Ile 
145                 150                 155                 160 


Leu Val Pro Gly Leu Ser Leu Gln Ala Ala Ser Gly Gln Glu Val Tyr 
                165                 170                 175     


Gln Val Asn Leu Thr Ala Ser Leu Gly Thr Trp Asp Val Ala Gly Glu 
            180                 185                 190         


Val Thr Gly Val Thr Leu Thr Gly Glu Gly Gln Ala Asp Leu Thr Leu 
        195                 200                 205             


Val Ser Pro Gly Leu Asp Gln Leu Asn Arg Gln Leu Gln Leu Val Thr 
    210                 215                 220                 


Tyr Ser Ser Arg Ser Tyr Gln Thr Asn Thr Ala Asp Thr Ala Gln Tyr 
225                 230                 235                 240 


Asn Ile Ser Ala Leu Val Thr Ile Ala Thr Lys Thr Phe Leu Arg Tyr 
                245                 250                 255     


Asp Arg Leu Arg Ala Leu Ile Thr Ser Ile Arg Arg Phe Tyr Pro Thr 
            260                 265                 270         


Val Thr Val Val Ile Ala Asp Asp Ser Asp Lys Pro Glu Arg Val Ser 
        275                 280                 285             


Gly Pro Tyr Val Glu His Tyr Leu Met Pro Phe Gly Lys Val Cys Ser 
    290                 295                 300                 


<210>  1351
<211>  328
<212>  PRT
<213>  Homo Sapiens

<400>  1351

Met Trp Leu Gly Arg Arg Ala Leu Cys Ala Leu Val Leu Leu Leu Ala 
1               5                   10                  15      


Cys Ala Ser Leu Gly Leu Leu Tyr Ala Ser Thr Arg Asp Ala Pro Gly 
            20                  25                  30          


Leu Arg Leu Pro Leu Ala Pro Trp Ala Pro Pro Gln Ser Pro Arg Arg 
        35                  40                  45              


Pro Glu Leu Pro Asp Leu Ala Pro Glu Pro Arg Tyr Ala His Ile Pro 
    50                  55                  60                  


Val Arg Ile Lys Glu Gln Val Val Gly Leu Leu Ala Trp Asn Asn Cys 
65                  70                  75                  80  


Ser Cys Glu Ser Ser Gly Gly Gly Leu Pro Leu Pro Phe Gln Lys Gln 
                85                  90                  95      


Val Arg Ala Ile Asp Leu Thr Lys Ala Phe Asp Pro Ala Glu Leu Arg 
            100                 105                 110         


Ala Ala Ser Ala Thr Arg Glu Gln Glu Phe Gln Ala Phe Leu Ser Arg 
        115                 120                 125             


Ser Gln Ser Pro Ala Asp Gln Leu Leu Ile Ala Pro Ala Asn Ser Pro 
    130                 135                 140                 


Leu Gln Tyr Pro Leu Gln Gly Val Glu Val Gln Pro Leu Arg Ser Ile 
145                 150                 155                 160 


Leu Val Pro Gly Leu Ser Leu Gln Ala Ala Ser Gly Gln Glu Val Tyr 
                165                 170                 175     


Gln Val Asn Leu Thr Ala Ser Leu Gly Thr Trp Asp Val Ala Gly Glu 
            180                 185                 190         


Val Thr Gly Val Thr Leu Thr Gly Glu Gly Gln Ala Asp Leu Thr Leu 
        195                 200                 205             


Val Ser Pro Gly Leu Asp Gln Leu Asn Arg Gln Leu Gln Leu Val Thr 
    210                 215                 220                 


Tyr Ser Ser Arg Ser Tyr Gln Thr Asn Thr Ala Asp Thr Gly Ala Arg 
225                 230                 235                 240 


Pro Gly Trp Arg Asp Gly Gln Ala Gly Gln Thr Glu Lys Asn Gln Lys 
                245                 250                 255     


Gly Trp Ser Gly Gln Met Ala Glu Gly Met Gly Gly Ile Trp Ala Met 
            260                 265                 270         


Ala Arg Ala Val Gln Pro His Asn Gly Cys Phe Asn Trp Thr Ser Arg 
        275                 280                 285             


Ala Arg Gly Arg Lys Gly Ala Phe Val His Leu Gly Leu Glu Gln Ala 
    290                 295                 300                 


Arg Gly Lys Pro Glu Pro Trp Val Cys Leu Pro Phe Arg Pro Thr Val 
305                 310                 315                 320 


Gly Gly Pro Arg Lys Arg Leu Val 
                325             


<210>  1352
<211>  328
<212>  PRT
<213>  Homo Sapiens

<400>  1352

Met Trp Leu Gly Arg Arg Ala Leu Cys Ala Leu Val Leu Leu Leu Ala 
1               5                   10                  15      


Cys Ala Ser Leu Gly Leu Leu Tyr Ala Ser Thr Arg Asp Ala Pro Gly 
            20                  25                  30          


Leu Arg Leu Pro Leu Ala Pro Trp Ala Pro Pro Gln Ser Pro Arg Arg 
        35                  40                  45              


Pro Glu Leu Pro Asp Leu Ala Pro Glu Pro Arg Tyr Ala His Ile Pro 
    50                  55                  60                  


Val Arg Ile Lys Glu Gln Val Val Gly Leu Leu Ala Trp Asn Asn Cys 
65                  70                  75                  80  


Ser Cys Glu Ser Ser Gly Gly Gly Leu Pro Leu Pro Phe Gln Lys Gln 
                85                  90                  95      


Val Arg Ala Ile Asp Leu Thr Lys Ala Phe Asp Pro Ala Glu Leu Arg 
            100                 105                 110         


Ala Ala Ser Ala Thr Arg Glu Gln Glu Phe Gln Ala Phe Leu Ser Arg 
        115                 120                 125             


Ser Gln Ser Pro Ala Asp Gln Leu Leu Ile Ala Pro Ala Asn Ser Pro 
    130                 135                 140                 


Leu Gln Tyr Pro Leu Gln Gly Val Glu Val Gln Pro Leu Arg Ser Ile 
145                 150                 155                 160 


Leu Val Pro Gly Leu Ser Leu Gln Ala Ala Ser Gly Gln Glu Val Tyr 
                165                 170                 175     


Gln Val Asn Leu Thr Ala Ser Leu Gly Thr Trp Asp Val Ala Gly Glu 
            180                 185                 190         


Val Thr Gly Val Thr Leu Thr Gly Glu Gly Gln Ala Asp Leu Thr Leu 
        195                 200                 205             


Val Ser Pro Gly Leu Asp Gln Leu Asn Arg Gln Leu Gln Leu Val Thr 
    210                 215                 220                 


Tyr Ser Ser Arg Ser Tyr Gln Thr Asn Thr Ala Asp Thr Gly Ala Arg 
225                 230                 235                 240 


Pro Gly Trp Arg Asp Gly Gln Ala Gly Gln Thr Glu Lys Asn Gln Lys 
                245                 250                 255     


Gly Trp Ser Gly Gln Met Ala Glu Gly Met Gly Gly Ile Trp Ala Met 
            260                 265                 270         


Ala Arg Ala Val Gln Pro His Asn Gly Cys Phe Asn Trp Thr Ser Arg 
        275                 280                 285             


Ala Arg Gly Arg Lys Gly Ala Phe Val His Leu Gly Leu Glu Gln Ala 
    290                 295                 300                 


Arg Gly Lys Pro Glu Pro Trp Val Cys Leu Pro Phe Arg Pro Thr Val 
305                 310                 315                 320 


Gly Gly Pro Arg Lys Arg Leu Val 
                325             


<210>  1353
<211>  533
<212>  PRT
<213>  Homo Sapiens

<400>  1353

Met Trp Leu Gly Arg Arg Ala Leu Cys Ala Leu Val Leu Leu Leu Ala 
1               5                   10                  15      


Cys Ala Ser Leu Gly Leu Leu Tyr Ala Ser Thr Arg Asp Ala Pro Gly 
            20                  25                  30          


Leu Arg Leu Pro Leu Ala Pro Trp Ala Pro Pro Gln Ser Pro Arg Arg 
        35                  40                  45              


Pro Glu Leu Pro Asp Leu Ala Pro Glu Pro Arg Tyr Ala His Ile Pro 
    50                  55                  60                  


Val Arg Ile Lys Glu Gln Val Val Gly Leu Leu Ala Trp Asn Asn Cys 
65                  70                  75                  80  


Ser Cys Glu Ser Ser Gly Gly Gly Leu Pro Leu Pro Phe Gln Lys Gln 
                85                  90                  95      


Val Arg Ala Ile Asp Leu Thr Lys Ala Phe Asp Pro Ala Glu Leu Arg 
            100                 105                 110         


Ala Ala Ser Ala Thr Arg Glu Gln Glu Phe Gln Ala Phe Leu Ser Arg 
        115                 120                 125             


Ser Gln Ser Pro Ala Asp Gln Leu Leu Ile Ala Pro Ala Asn Ser Pro 
    130                 135                 140                 


Leu Gln Tyr Pro Leu Gln Gly Val Glu Val Gln Pro Leu Arg Ser Ile 
145                 150                 155                 160 


Leu Val Pro Gly Leu Ser Leu Gln Ala Ala Ser Gly Gln Glu Val Tyr 
                165                 170                 175     


Gln Val Asn Leu Thr Ala Ser Leu Gly Thr Trp Asp Val Ala Gly Glu 
            180                 185                 190         


Val Thr Gly Val Thr Leu Thr Gly Glu Gly Gln Ala Asp Leu Thr Leu 
        195                 200                 205             


Val Ser Pro Gly Leu Asp Gln Leu Asn Arg Gln Leu Gln Leu Val Thr 
    210                 215                 220                 


Tyr Ser Ser Arg Ser Tyr Gln Thr Asn Thr Ala Asp Thr Val Arg Phe 
225                 230                 235                 240 


Ser Thr Glu Gly His Glu Ala Ala Phe Thr Ile Arg Ile Arg His Pro 
                245                 250                 255     


Pro Asn Pro Arg Leu Tyr Pro Pro Gly Ser Leu Pro Gln Gly Ala Gln 
            260                 265                 270         


Tyr Asn Ile Ser Ala Leu Val Thr Ile Ala Thr Lys Thr Phe Leu Arg 
        275                 280                 285             


Tyr Asp Arg Leu Arg Ala Leu Ile Thr Ser Ile Arg Arg Phe Tyr Pro 
    290                 295                 300                 


Thr Val Thr Val Val Ile Ala Asp Asp Ser Asp Lys Pro Glu Arg Val 
305                 310                 315                 320 


Ser Gly Pro Tyr Val Glu His Tyr Leu Met Pro Phe Gly Lys Gly Trp 
                325                 330                 335     


Phe Ala Gly Arg Asn Leu Ala Val Ser Gln Val Thr Thr Lys Tyr Val 
            340                 345                 350         


Leu Trp Val Asp Asp Asp Phe Val Phe Thr Ala Arg Thr Arg Leu Glu 
        355                 360                 365             


Arg Leu Val Asp Val Leu Glu Arg Thr Pro Leu Asp Leu Val Gly Gly 
    370                 375                 380                 


Ala Val Arg Glu Ile Ser Gly Phe Ala Thr Thr Tyr Arg Gln Leu Leu 
385                 390                 395                 400 


Ser Val Glu Pro Gly Ala Pro Gly Leu Gly Asn Cys Leu Arg Gln Arg 
                405                 410                 415     


Arg Gly Phe His His Glu Leu Val Gly Phe Pro Gly Cys Val Val Thr 
            420                 425                 430         


Asp Gly Val Val Asn Phe Phe Leu Ala Arg Thr Asp Lys Val Arg Glu 
        435                 440                 445             


Val Gly Phe Asp Pro Arg Leu Ser Arg Val Ala His Leu Glu Phe Phe 
    450                 455                 460                 


Leu Asp Gly Leu Gly Ser Leu Arg Val Gly Ser Cys Ser Asp Val Val 
465                 470                 475                 480 


Val Asp His Ala Ser Lys Leu Lys Leu Pro Trp Thr Ser Arg Asp Ala 
                485                 490                 495     


Gly Ala Glu Thr Tyr Ala Arg Tyr Arg Tyr Pro Gly Ser Leu Asp Glu 
            500                 505                 510         


Ser Gln Met Ala Lys His Arg Leu Leu Phe Phe Lys His Arg Leu Gln 
        515                 520                 525             


Cys Met Thr Ser Gln 
    530             


<210>  1354
<211>  478
<212>  PRT
<213>  Homo Sapiens

<400>  1354

Met Trp Leu Gly Arg Arg Ala Leu Cys Ala Leu Val Leu Leu Leu Ala 
1               5                   10                  15      


Cys Ala Ser Leu Gly Leu Leu Tyr Ala Ser Thr Arg Asp Ala Pro Gly 
            20                  25                  30          


Leu Arg Leu Pro Leu Ala Pro Trp Ala Pro Pro Gln Ser Pro Arg Arg 
        35                  40                  45              


Pro Glu Leu Pro Asp Leu Ala Pro Glu Pro Arg Tyr Ala His Ile Pro 
    50                  55                  60                  


Val Arg Ile Lys Glu Gln Val Val Gly Ser Gln Ser Pro Ala Asp Gln 
65                  70                  75                  80  


Leu Leu Ile Ala Pro Ala Asn Ser Pro Leu Gln Tyr Pro Leu Gln Gly 
                85                  90                  95      


Val Glu Val Gln Pro Leu Arg Ser Ile Leu Val Pro Gly Leu Ser Leu 
            100                 105                 110         


Gln Ala Ala Ser Gly Gln Glu Val Tyr Gln Val Asn Leu Thr Ala Ser 
        115                 120                 125             


Leu Gly Thr Trp Asp Val Ala Gly Glu Val Thr Gly Val Thr Leu Thr 
    130                 135                 140                 


Gly Glu Gly Gln Ala Asp Leu Thr Leu Val Ser Pro Gly Leu Asp Gln 
145                 150                 155                 160 


Leu Asn Arg Gln Leu Gln Leu Val Thr Tyr Ser Ser Arg Ser Tyr Gln 
                165                 170                 175     


Thr Asn Thr Ala Asp Thr Val Arg Phe Ser Thr Glu Gly His Glu Ala 
            180                 185                 190         


Ala Phe Thr Ile Arg Ile Arg His Pro Pro Asn Pro Arg Leu Tyr Pro 
        195                 200                 205             


Pro Gly Ser Leu Pro Gln Gly Ala Gln Tyr Asn Ile Ser Ala Leu Val 
    210                 215                 220                 


Thr Ile Ala Thr Lys Thr Phe Leu Arg Tyr Asp Arg Leu Arg Ala Leu 
225                 230                 235                 240 


Ile Thr Ser Ile Arg Arg Phe Tyr Pro Thr Val Thr Val Val Ile Ala 
                245                 250                 255     


Asp Asp Ser Asp Lys Pro Glu Arg Val Ser Gly Pro Tyr Val Glu His 
            260                 265                 270         


Tyr Leu Met Pro Phe Gly Lys Gly Trp Phe Ala Gly Arg Asn Leu Ala 
        275                 280                 285             


Val Ser Gln Val Thr Thr Lys Tyr Val Leu Trp Val Asp Asp Asp Phe 
    290                 295                 300                 


Val Phe Thr Ala Arg Thr Arg Leu Glu Arg Leu Val Asp Val Leu Glu 
305                 310                 315                 320 


Arg Thr Pro Leu Asp Leu Val Gly Gly Ala Val Arg Glu Ile Ser Gly 
                325                 330                 335     


Phe Ala Thr Thr Tyr Arg Gln Leu Leu Ser Val Glu Pro Gly Ala Pro 
            340                 345                 350         


Gly Leu Gly Asn Cys Leu Arg Gln Arg Arg Gly Phe His His Glu Leu 
        355                 360                 365             


Val Gly Phe Pro Gly Cys Val Val Thr Asp Gly Val Val Asn Phe Phe 
    370                 375                 380                 


Leu Ala Arg Thr Asp Lys Val Arg Glu Val Gly Phe Asp Pro Arg Leu 
385                 390                 395                 400 


Ser Arg Val Ala His Leu Glu Phe Phe Leu Asp Gly Leu Gly Ser Leu 
                405                 410                 415     


Arg Val Gly Ser Cys Ser Asp Val Val Val Asp His Ala Ser Lys Leu 
            420                 425                 430         


Lys Leu Pro Trp Thr Ser Arg Asp Ala Gly Ala Glu Thr Tyr Ala Arg 
        435                 440                 445             


Tyr Arg Tyr Pro Gly Ser Leu Asp Glu Ser Gln Met Ala Lys His Arg 
    450                 455                 460                 


Leu Leu Phe Phe Lys His Arg Leu Gln Cys Met Thr Ser Gln 
465                 470                 475             


<210>  1355
<211>  151
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1355

Xaa Met Pro Phe Gly Lys Gly Trp Phe Ala Gly Arg Asn Leu Ala Val 
1               5                   10                  15      


Ser Gln Val Thr Thr Lys Tyr Val Leu Trp Val Asp Asp Asp Phe Val 
            20                  25                  30          


Phe Thr Ala Arg Thr Arg Leu Glu Arg Leu Val Asp Val Leu Glu Arg 
        35                  40                  45              


Thr Pro Leu Asp Leu Ala Arg Leu Glu Ala Thr Ser Leu Ser Leu Gln 
    50                  55                  60                  


Val Gly Gly Ala Val Arg Glu Ile Ser Gly Phe Ala Thr Thr Tyr Arg 
65                  70                  75                  80  


Gln Leu Leu Ser Val Glu Pro Gly Ala Pro Gly Leu Gly Asn Cys Leu 
                85                  90                  95      


Arg Gln Arg Arg Gly Phe His His Glu Leu Val Gly Phe Pro Gly Cys 
            100                 105                 110         


Val Val Thr Asp Gly Val Val Asn Phe Phe Leu Ala Arg Thr Asp Lys 
        115                 120                 125             


Val Arg Glu Val Gly Phe Asp Pro Arg Leu Ser Arg Val Ala His Leu 
    130                 135                 140                 


Glu Phe Phe Leu Asp Gly Leu 
145                 150     


<210>  1356
<211>  127
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1356

Xaa Ser Gln Ser Pro Ala Asp Gln Leu Leu Ile Ala Pro Ala Asn Ser 
1               5                   10                  15      


Pro Leu Gln Tyr Pro Leu Gln Gly Val Glu Val Gln Pro Leu Arg Ser 
            20                  25                  30          


Ile Leu Val Pro Gly Leu Ser Leu Gln Ala Ala Ser Gly Gln Glu Val 
        35                  40                  45              


Tyr Gln Val Asn Leu Thr Ala Ser Leu Gly Thr Trp Asp Val Ala Gly 
    50                  55                  60                  


Glu Val Thr Gly Val Thr Leu Thr Gly Glu Gly Gln Ala Asp Leu Thr 
65                  70                  75                  80  


Leu Val Ser Pro Gly Leu Asp Gln Leu Asn Arg Gln Leu Gln Leu Val 
                85                  90                  95      


Thr Tyr Ser Ser Arg Ser Tyr Gln Thr Asn Thr Ala Asp Thr Gly Ser 
            100                 105                 110         


Asn Ala Met Ser Phe Leu Pro Ser Pro Val Leu His Arg Gly Thr 
        115                 120                 125         


<210>  1357
<211>  637
<212>  PRT
<213>  Homo Sapiens

<400>  1357

Met Ala Arg Ala Asp Leu Val Pro Lys Ala Arg Pro Trp Gly Glu His 
1               5                   10                  15      


Gln His Gln Phe Arg Gly Arg Ala Asn Leu His Val Phe Glu Asp Trp 
            20                  25                  30          


Cys Gly Ser Ser Ile Gln Gln Leu Arg Arg Asn Leu His Phe Pro Leu 
        35                  40                  45              


Tyr Pro His Ile Arg Thr Thr Leu Arg Lys Leu Ala Val Ser Pro Lys 
    50                  55                  60                  


Trp Thr Asn Tyr Gly Leu Arg Ile Phe Gly Tyr Leu His Pro Phe Thr 
65                  70                  75                  80  


Asp Gly Lys Ile Gln Phe Ala Ile Ala Ala Asp Asp Asn Ala Glu Phe 
                85                  90                  95      


Trp Leu Ser Leu Asp Asp Gln Val Ser Gly Leu Gln Leu Leu Ala Ser 
            100                 105                 110         


Val Gly Lys Thr Gly Lys Glu Trp Thr Ala Pro Gly Glu Phe Gly Lys 
        115                 120                 125             


Phe Arg Ser Gln Ile Ser Lys Pro Val Ser Leu Ser Ala Ser His Arg 
    130                 135                 140                 


Tyr Tyr Phe Glu Val Leu His Lys Gln Asn Glu Glu Gly Thr Asp His 
145                 150                 155                 160 


Val Glu Val Ala Trp Arg Arg Asn Asp Pro Gly Ala Lys Phe Thr Ile 
                165                 170                 175     


Ile Asp Ser Leu Ser Leu Ser Leu Phe Thr Asn Glu Thr Phe Leu Gln 
            180                 185                 190         


Met Asp Glu Val Gly His Ile Pro Gln Thr Ala Ala Ser His Val Asp 
        195                 200                 205             


Ser Ser Asn Ala Leu Pro Arg Asp Glu Gln Pro Pro Ala Asp Met Leu 
    210                 215                 220                 


Arg Pro Asp Pro Arg Asp Thr Leu Tyr Arg Val Pro Leu Ile Pro Lys 
225                 230                 235                 240 


Ser His Leu Arg His Val Leu Pro Asp Cys Pro Tyr Lys Pro Ser Tyr 
                245                 250                 255     


Leu Val Asp Gly Leu Pro Leu Gln Arg Tyr Gln Gly Leu Arg Phe Val 
            260                 265                 270         


His Leu Ser Phe Val Tyr Pro Asn Asp Tyr Thr Arg Leu Ser His Met 
        275                 280                 285             


Glu Thr His Asn Lys Cys Phe Tyr Gln Glu Asn Ala Tyr Tyr Gln Asp 
    290                 295                 300                 


Arg Phe Ser Phe Gln Glu Tyr Ile Lys Ile Asp Gln Pro Glu Lys Gln 
305                 310                 315                 320 


Gly Leu Glu Gln Pro Ala Gly Phe Glu Glu Asn Leu Leu Glu Glu Ser 
                325                 330                 335     


Gln Tyr Gly Glu Val Ala Glu Glu Thr Pro Ala Ser Asn Asn Gln Asn 
            340                 345                 350         


Ala Arg Met Leu Glu Gly Arg Gln Thr Pro Ala Ser Thr Leu Glu Gln 
        355                 360                 365             


Asp Ala Thr Asp Tyr Arg Leu Arg Ser Leu Arg Lys Leu Leu Ala Gln 
    370                 375                 380                 


Pro Arg Glu Gly Leu Leu Ala Pro Phe Ser Lys Arg Asn Ser Thr Ala 
385                 390                 395                 400 


Ser Phe Pro Gly Arg Thr Ser His Ile Pro Val Gln Gln Pro Glu Lys 
                405                 410                 415     


Arg Lys Gln Lys Pro Ser Pro Glu Pro Ser Gln Asp Ser Pro His Ser 
            420                 425                 430         


Asp Lys Trp Pro Pro Gly His Pro Val Lys Asn Leu Pro Gln Met Arg 
        435                 440                 445             


Gly Pro Arg Pro Arg Pro Ala Gly Asp Ser Pro Arg Lys Thr Gln Trp 
    450                 455                 460                 


Leu Asn Gln Val Glu Ser Tyr Ile Ala Glu Gln Arg Arg Gly Asp Arg 
465                 470                 475                 480 


Met Arg Pro Gln Ala Pro Gly Arg Gly Trp His Gly Glu Glu Glu Val 
                485                 490                 495     


Val Ala Ala Ala Gly Gln Glu Gly Gln Val Glu Gly Glu Glu Glu Gly 
            500                 505                 510         


Glu Glu Glu Glu Glu Glu Glu Asp Met Ser Glu Val Phe Glu Tyr Val 
        515                 520                 525             


Pro Val Phe Asp Pro Val Val Asn Trp Asp Gln Thr Phe Ser Ala Arg 
    530                 535                 540                 


Asn Leu Asp Phe Gln Ala Leu Arg Thr Asp Trp Ile Asp Leu Ser Cys 
545                 550                 555                 560 


Asn Thr Ser Gly Asn Leu Leu Leu Pro Glu Gln Glu Ala Leu Glu Val 
                565                 570                 575     


Thr Arg Val Phe Leu Lys Lys Leu Asn Gln Arg Ser Arg Gly Ser Val 
            580                 585                 590         


Asp Phe Pro Ile Pro Asp Ile Leu Cys Lys Trp Asn His Val Met Cys 
        595                 600                 605             


Gly Leu Tyr Ile Gly Leu Phe Ala Glu Tyr Ser Leu Ser Thr Ser Phe 
    610                 615                 620                 


Ile Arg Val Val Glu Ser Ile Lys His Phe Ile Pro Arg 
625                 630                 635         


<210>  1358
<211>  998
<212>  PRT
<213>  Homo Sapiens

<400>  1358

Met Gly Ser Pro Arg Ala Ala Arg Pro Pro Leu Leu Leu Arg Pro Val 
1               5                   10                  15      


Lys Leu Leu Arg Arg Arg Phe Arg Leu Leu Leu Ala Leu Ala Val Val 
            20                  25                  30          


Ser Val Gly Leu Trp Thr Leu Tyr Leu Glu Leu Val Ala Ser Ala Gln 
        35                  40                  45              


Val Gly Gly Asn Pro Leu Asn Arg Arg Tyr Gly Ser Trp Arg Glu Leu 
    50                  55                  60                  


Ala Lys Ala Leu Ala Ser Arg Asn Ile Pro Ala Val Asp Pro His Leu 
65                  70                  75                  80  


Gln Phe Tyr His Pro Gln Arg Leu Ser Leu Glu Asp His Asp Ile Asp 
                85                  90                  95      


Gln Gly Val Ser Ser Asn Ser Ser Tyr Leu Lys Trp Asn Lys Pro Val 
            100                 105                 110         


Pro Trp Leu Ser Glu Phe Arg Gly Arg Ala Asn Leu His Val Phe Glu 
        115                 120                 125             


Asp Trp Cys Gly Ser Ser Ile Gln Gln Leu Arg Arg Asn Leu His Phe 
    130                 135                 140                 


Pro Leu Tyr Pro His Ile Arg Thr Thr Leu Arg Lys Leu Ala Val Ser 
145                 150                 155                 160 


Pro Lys Trp Thr Asn Tyr Gly Leu Arg Ile Phe Gly Tyr Leu His Pro 
                165                 170                 175     


Phe Thr Asp Gly Lys Ile Gln Phe Ala Ile Ala Ala Asp Asp Asn Ala 
            180                 185                 190         


Glu Phe Trp Leu Ser Leu Asp Asp Gln Val Ser Gly Leu Gln Leu Leu 
        195                 200                 205             


Ala Ser Val Gly Lys Thr Gly Lys Glu Trp Thr Ala Pro Gly Glu Phe 
    210                 215                 220                 


Gly Lys Phe Arg Ser Gln Ile Ser Lys Pro Val Ser Leu Ser Ala Ser 
225                 230                 235                 240 


His Arg Tyr Tyr Phe Glu Val Leu His Lys Gln Asn Glu Glu Gly Thr 
                245                 250                 255     


Asp His Val Glu Val Ala Trp Arg Arg Asn Asp Pro Gly Ala Lys Phe 
            260                 265                 270         


Thr Ile Ile Asp Ser Leu Ser Leu Ser Leu Phe Thr Asn Glu Thr Phe 
        275                 280                 285             


Leu Gln Met Asp Glu Val Gly His Ile Pro Gln Thr Ala Ala Ser His 
    290                 295                 300                 


Val Asp Ser Ser Asn Ala Leu Pro Arg Asp Glu Gln Pro Pro Ala Asp 
305                 310                 315                 320 


Met Leu Arg Pro Asp Pro Arg Asp Thr Leu Tyr Arg Val Pro Leu Ile 
                325                 330                 335     


Pro Lys Ser His Leu Arg His Val Leu Pro Asp Cys Pro Tyr Lys Pro 
            340                 345                 350         


Ser Tyr Leu Val Asp Gly Leu Pro Leu Gln Arg Tyr Gln Gly Leu Arg 
        355                 360                 365             


Phe Val His Leu Ser Phe Val Tyr Pro Asn Asp Tyr Thr Arg Leu Ser 
    370                 375                 380                 


His Met Glu Thr His Asn Lys Cys Phe Tyr Gln Glu Asn Ala Tyr Tyr 
385                 390                 395                 400 


Gln Asp Arg Phe Ser Phe Gln Glu Tyr Ile Lys Ile Asp Gln Pro Glu 
                405                 410                 415     


Lys Gln Gly Leu Glu Gln Pro Gly Phe Glu Glu Asn Leu Leu Glu Glu 
            420                 425                 430         


Ser Gln Tyr Gly Glu Val Ala Glu Glu Thr Pro Ala Ser Asn Asn Gln 
        435                 440                 445             


Asn Ala Arg Met Leu Glu Gly Arg Gln Thr Pro Ala Ser Thr Leu Glu 
    450                 455                 460                 


Gln Asp Ala Thr Asp Tyr Arg Leu Arg Ser Leu Arg Lys Leu Leu Ala 
465                 470                 475                 480 


Gln Pro Arg Glu Gly Leu Leu Ala Pro Phe Ser Lys Arg Asn Ser Thr 
                485                 490                 495     


Ala Ser Phe Pro Gly Arg Thr Ser His Ile Pro Val Gln Gln Pro Glu 
            500                 505                 510         


Lys Arg Lys Gln Lys Pro Ser Pro Glu Pro Ser Gln Asp Ser Pro His 
        515                 520                 525             


Ser Asp Lys Trp Pro Pro Gly His Pro Val Lys Asn Leu Pro Gln Met 
    530                 535                 540                 


Arg Gly Pro Arg Pro Arg Pro Ala Gly Asp Ser Pro Arg Lys Thr Gln 
545                 550                 555                 560 


Trp Leu Asn Gln Val Glu Ser Tyr Ile Ala Glu Gln Arg Arg Gly Asp 
                565                 570                 575     


Arg Met Arg Pro Gln Ala Pro Gly Arg Gly Trp His Gly Glu Glu Glu 
            580                 585                 590         


Val Val Ala Ala Ala Gly Gln Glu Gly Gln Val Glu Gly Glu Glu Glu 
        595                 600                 605             


Gly Glu Glu Glu Glu Glu Glu Glu Asp Met Ser Glu Val Phe Glu Tyr 
    610                 615                 620                 


Val Pro Val Phe Asp Pro Val Val Asn Trp Asp Gln Thr Phe Ser Ala 
625                 630                 635                 640 


Arg Asn Leu Asp Phe Gln Ala Leu Arg Thr Asp Trp Ile Asp Leu Ser 
                645                 650                 655     


Cys Asn Thr Ser Gly Asn Leu Leu Leu Pro Glu Gln Glu Ala Leu Glu 
            660                 665                 670         


Val Thr Arg Val Phe Leu Lys Lys Leu Asn Gln Arg Ser Arg Gly Arg 
        675                 680                 685             


Tyr Gln Leu Gln Arg Ile Val Asn Val Glu Lys Arg Gln Asp Gln Leu 
    690                 695                 700                 


Arg Gly Gly Arg Tyr Leu Leu Glu Leu Glu Leu Leu Glu Gln Gly Gln 
705                 710                 715                 720 


Arg Val Val Arg Leu Ser Glu Tyr Val Ser Ala Arg Gly Trp Gln Gly 
                725                 730                 735     


Ile Asp Pro Ala Gly Gly Glu Glu Val Glu Ala Arg Asn Leu Gln Gly 
            740                 745                 750         


Leu Val Trp Asp Pro His Asn Arg Arg Arg Gln Val Leu Asn Thr Arg 
        755                 760                 765             


Ala Gln Glu Pro Lys Leu Cys Trp Pro Gln Gly Phe Ser Trp Ser His 
    770                 775                 780                 


Arg Ala Val Val His Phe Val Val Pro Val Lys Asn Gln Ala Arg Trp 
785                 790                 795                 800 


Val Gln Gln Phe Ile Lys Asp Met Glu Asn Leu Phe Gln Val Thr Gly 
                805                 810                 815     


Asp Pro His Phe Asn Ile Val Ile Thr Asp Tyr Ser Ser Glu Asp Met 
            820                 825                 830         


Asp Val Glu Met Ala Leu Lys Arg Ser Lys Leu Arg Ser Tyr Gln Tyr 
        835                 840                 845             


Val Lys Leu Ser Gly Asn Phe Glu Arg Ser Ala Gly Leu Gln Ala Gly 
    850                 855                 860                 


Ile Asp Leu Val Lys Asp Pro His Ser Ile Ile Phe Leu Cys Asp Leu 
865                 870                 875                 880 


His Ile His Phe Pro Ala Gly Val Ile Asp Ala Ile Arg Lys His Cys 
                885                 890                 895     


Val Glu Gly Lys Met Ala Phe Ala Pro Met Val Met Arg Leu His Cys 
            900                 905                 910         


Gly Ala Thr Pro Gln Trp Pro Glu Gly Tyr Trp Glu Val Asn Gly Phe 
        915                 920                 925             


Gly Leu Leu Gly Ile Tyr Lys Ser Asp Leu Asp Arg Ile Gly Gly Met 
    930                 935                 940                 


Asn Thr Lys Glu Phe Arg Asp Arg Trp Gly Gly Glu Asp Trp Glu Leu 
945                 950                 955                 960 


Leu Asp Arg Ile Leu Gln Ala Gly Leu Asp Val Glu Arg Leu Ser Leu 
                965                 970                 975     


Arg Asn Phe Phe His His Phe His Ser Lys Arg Gly Met Trp Ser Arg 
            980                 985                 990         


Arg Gln Met Lys Thr Leu 
        995             


<210>  1359
<211>  53
<212>  PRT
<213>  Homo Sapiens

<400>  1359

Asp Ala Ser Ser Ile Val Phe Leu Cys Asp Leu His Ile His Phe Pro 
1               5                   10                  15      


Pro Asn Ile Leu Asp Gly Ile Arg Lys His Cys Val Glu Gly Arg Leu 
            20                  25                  30          


Ala Phe Ala Pro Val Val Met Arg Leu Ser Cys Gly Ser Ser Pro Arg 
        35                  40                  45              


Asp Pro His Gly Ser 
    50              


<210>  1360
<211>  26
<212>  PRT
<213>  Homo Sapiens

<400>  1360

Asp Val Glu Arg Ala Leu Arg Ala Ala Arg Leu Pro Arg Asp Arg Ala 
1               5                   10                  15      


Cys Asp Ser Pro Ser Pro Gly Thr Ser Thr 
            20                  25      


<210>  1361
<211>  1039
<212>  PRT
<213>  Homo Sapiens

<400>  1361

Met Pro Arg Leu Pro Val Lys Lys Ile Arg Lys Gln Met Lys Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Ser Cys Ala Ala Trp Leu Thr Tyr Val His 
            20                  25                  30          


Leu Gly Leu Val Arg Gln Gly Arg Ala Leu Arg Gln Arg Leu Gly Tyr 
        35                  40                  45              


Gly Arg Asp Gly Glu Lys Leu Thr Ser Glu Thr Asp Gly Arg Gly Val 
    50                  55                  60                  


His Ala Ala Pro Ser Thr Gln Arg Ala Glu Asp Ser Ser Glu Ser Arg 
65                  70                  75                  80  


Glu Glu Glu Gln Ala Pro Glu Gly Arg Asp Leu Asp Met Leu Phe Pro 
                85                  90                  95      


Gly Gly Ala Gly Arg Leu Pro Leu Asn Phe Thr His Gln Thr Pro Pro 
            100                 105                 110         


Trp Arg Glu Glu Tyr Lys Gly Gln Val Asn Leu His Val Phe Glu Asp 
        115                 120                 125             


Trp Cys Gly Gly Ala Val Gly His Leu Arg Arg Asn Leu His Phe Pro 
    130                 135                 140                 


Leu Phe Pro His Thr Arg Thr Thr Val Lys Lys Leu Ala Val Ser Pro 
145                 150                 155                 160 


Lys Trp Lys Asn Tyr Gly Leu Arg Ile Phe Gly Phe Ile His Pro Ala 
                165                 170                 175     


Arg Asp Gly Asp Val Gln Phe Ser Val Ala Ser Asp Asp Asn Ser Glu 
            180                 185                 190         


Phe Trp Leu Ser Leu Asp Glu Ser Pro Ala Ala Ala Gln Leu Val Ala 
        195                 200                 205             


Phe Val Gly Lys Thr Gly Ser Glu Trp Thr Ala Pro Gly Glu Phe Thr 
    210                 215                 220                 


Lys Phe Ser Ser Gln Val Ser Lys Pro Arg Arg Leu Met Ala Ser Arg 
225                 230                 235                 240 


Arg Tyr Tyr Phe Glu Leu Leu His Lys Gln Asp Asp Arg Gly Ser Asp 
                245                 250                 255     


His Val Glu Val Gly Trp Arg Ala Phe Leu Pro Gly Leu Lys Phe Glu 
            260                 265                 270         


Val Ile Ser Ser Ala His Ile Ser Leu Tyr Thr Asp Glu Ser Ala Leu 
        275                 280                 285             


Lys Met Asp His Val Ala His Val Pro Gln Ser Pro Ala Ser His Val 
    290                 295                 300                 


Gly Gly Arg Pro Pro Gln Glu Glu Thr Ser Ala Asp Met Leu Arg Pro 
305                 310                 315                 320 


Asp Pro Arg Asp Thr Phe Phe Leu Thr Pro Arg Met Glu Ser Ser Ser 
                325                 330                 335     


Leu Glu Asn Val Leu Glu Pro Cys Ala Tyr Ala Pro Thr Tyr Val Val 
            340                 345                 350         


Lys Asp Phe Pro Ile Ala Arg Tyr Gln Gly Leu Gln Phe Val Tyr Leu 
        355                 360                 365             


Ser Phe Val Tyr Pro Asn Asp Tyr Thr Arg Leu Thr His Met Glu Thr 
    370                 375                 380                 


Asp Asn Lys Cys Phe Tyr Arg Glu Ser Pro Leu Tyr Leu Glu Arg Phe 
385                 390                 395                 400 


Gly Phe Tyr Lys Tyr Met Lys Met Asp Lys Glu Glu Gly Asp Glu Asp 
                405                 410                 415     


Glu Glu Asp Glu Val Gln Arg Arg Ala Phe Leu Phe Leu Asn Pro Asp 
            420                 425                 430         


Asp Phe Leu Asp Asp Glu Asp Glu Gly Glu Leu Leu Asp Ser Leu Glu 
        435                 440                 445             


Pro Thr Glu Ala Ala Pro Pro Arg Ser Gly Pro Gln Ser Pro Ala Pro 
    450                 455                 460                 


Ala Ala Pro Ala Gln Pro Gly Ala Thr Leu Ala Pro Pro Thr Pro Pro 
465                 470                 475                 480 


Arg Pro Arg Asp Gly Gly Thr Pro Arg His Ser Arg Ala Leu Ser Trp 
                485                 490                 495     


Ala Ala Arg Ala Ala Arg Pro Leu Pro Leu Phe Leu Gly Arg Ala Pro 
            500                 505                 510         


Pro Pro Arg Pro Ala Val Glu Gln Pro Pro Pro Lys Val Tyr Val Thr 
        515                 520                 525             


Arg Val Arg Pro Gly Gln Arg Ala Ser Pro Arg Ala Pro Ala Pro Arg 
    530                 535                 540                 


Ala Pro Trp Pro Pro Phe Pro Gly Val Phe Leu His Pro Arg Pro Leu 
545                 550                 555                 560 


Pro Arg Val Gln Leu Arg Ala Pro Pro Arg Pro Pro Arg Pro His Gly 
                565                 570                 575     


Arg Arg Thr Gly Gly Pro Gln Ala Thr Gln Pro Arg Pro Pro Ala Arg 
            580                 585                 590         


Ala Gln Ala Thr Gln Gly Gly Arg Glu Gly Gln Ala Arg Thr Leu Gly 
        595                 600                 605             


Pro Ala Ala Pro Thr Val Asp Ser Asn Leu Ser Ser Glu Ala Arg Pro 
    610                 615                 620                 


Val Thr Ser Phe Leu Ser Leu Ser Gln Val Ser Gly Pro Gln Leu Pro 
625                 630                 635                 640 


Gly Glu Gly Glu Glu Glu Glu Glu Gly Glu Asp Asp Gly Ala Pro Gly 
                645                 650                 655     


Asp Glu Ala Ala Ser Glu Asp Ser Glu Glu Ala Ala Gly Pro Ala Leu 
            660                 665                 670         


Gly Arg Trp Arg Glu Asp Ala Ile Asp Trp Gln Arg Thr Phe Ser Val 
        675                 680                 685             


Gly Ala Val Asp Phe Glu Leu Leu Arg Ser Asp Trp Asn Asp Leu Arg 
    690                 695                 700                 


Cys Asn Val Ser Gly Asn Leu Gln Leu Pro Glu Ala Glu Ala Val Asp 
705                 710                 715                 720 


Val Thr Ala Gln Tyr Met Glu Arg Leu Asn Ala Arg His Gly Gly Arg 
                725                 730                 735     


Phe Ala Leu Leu Arg Ile Val Asn Val Glu Lys Arg Arg Asp Ser Ala 
            740                 745                 750         


Arg Gly Ser Arg Phe Leu Leu Glu Leu Glu Leu Gln Glu Arg Gly Gly 
        755                 760                 765             


Gly Arg Leu Arg Leu Ser Glu Tyr Val Phe Leu Arg Leu Pro Gly Ala 
    770                 775                 780                 


Arg Val Gly Asp Ala Asp Gly Glu Ser Pro Glu Pro Ala Pro Ala Ala 
785                 790                 795                 800 


Ser Val Arg Pro Asp Gly Arg Pro Glu Leu Cys Arg Pro Leu Arg Leu 
                805                 810                 815     


Ala Trp Arg Gln Asp Val Met Val His Phe Ile Val Pro Val Lys Asn 
            820                 825                 830         


Gln Ala Arg Trp Val Ala Gln Phe Leu Ala Asp Met Ala Ala Leu His 
        835                 840                 845             


Ala Arg Thr Gly Asp Ser Arg Phe Ser Val Val Leu Val Asp Phe Glu 
    850                 855                 860                 


Ser Glu Asp Met Asp Val Glu Arg Ala Leu Arg Ala Ala Arg Leu Pro 
865                 870                 875                 880 


Arg Tyr Gln Tyr Leu Arg Arg Thr Gly Asn Phe Glu Arg Ser Ala Gly 
                885                 890                 895     


Leu Gln Ala Gly Val Asp Ala Val Glu Asp Ala Ser Ser Ile Val Phe 
            900                 905                 910         


Leu Cys Asp Leu His Ile His Phe Pro Pro Asn Ile Leu Asp Gly Ile 
        915                 920                 925             


Arg Lys His Cys Val Glu Gly Arg Leu Ala Phe Ala Pro Val Val Met 
    930                 935                 940                 


Arg Leu Ser Cys Gly Ser Ser Pro Arg Asp Pro His Gly Tyr Trp Glu 
945                 950                 955                 960 


Val Asn Gly Phe Gly Leu Phe Gly Ile Tyr Lys Ser Asp Phe Asp Arg 
                965                 970                 975     


Val Gly Gly Met Asn Thr Glu Glu Phe Arg Asp Gln Trp Gly Gly Glu 
            980                 985                 990         


Asp Trp Glu Leu Leu Asp Arg Val  Leu Gln Ala Gly Leu  Glu Val Glu 
        995                 1000                 1005             


Arg Leu  Arg Leu Arg Asn Phe  Tyr His His Tyr His  Ser Lys Arg 
    1010                 1015                 1020             


Gly Met  Trp Ser Val Arg Ser  Arg Lys Gly Ser Arg  Thr Gly Ala 
    1025                 1030                 1035             


Ser 
    


<210>  1362
<211>  62
<212>  PRT
<213>  Homo Sapiens

<400>  1362

Met Ala Asn Phe His Lys Thr Leu Ile Leu Gly Lys Gly Lys Thr Leu 
1               5                   10                  15      


Thr Asn Glu Ala Ser Thr Lys Lys Val Glu Leu Asp Asn Cys Pro Ser 
            20                  25                  30          


Val Ser Pro Tyr Leu Arg Gly Gln Ser Lys Leu Ile Phe Lys Pro Asp 
        35                  40                  45              


Leu Thr Leu Glu Glu Val Gln Glu Ile Arg Leu Leu Asn Val 
    50                  55                  60          


<210>  1363
<211>  6
<212>  PRT
<213>  Homo Sapiens

<400>  1363

Met Gly Phe Asn Leu Thr 
1               5       


<210>  1364
<211>  21
<212>  PRT
<213>  Homo Sapiens

<400>  1364

Met Gly Phe Asn Leu Thr Phe His Leu Ser Tyr Lys Phe Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Thr Leu 
            20      


<210>  1365
<211>  42
<212>  PRT
<213>  Homo Sapiens

<400>  1365

Met Gly Phe Asn Leu Thr Phe His Leu Ser Tyr Lys Phe Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Thr Leu Cys Leu Thr Val Val Gly Trp Ala Thr Ser Asn 
            20                  25                  30          


Tyr Phe Val Gly Ala Ile Gln Glu Ile Pro 
        35                  40          


<210>  1366
<211>  55
<212>  PRT
<213>  Homo Sapiens

<400>  1366

Met Gly Phe Asn Leu Thr Phe His Leu Ser Tyr Lys Phe Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Thr Leu Cys Leu Thr Val Val Gly Trp Ala Thr Ser Asn 
            20                  25                  30          


Tyr Phe Val Gly Ala Ile Gln Glu Ile Pro Lys Ala Lys Glu Phe Met 
        35                  40                  45              


Ala Asn Phe His Lys Thr Leu 
    50                  55  


<210>  1367
<211>  118
<212>  PRT
<213>  Homo Sapiens

<400>  1367

Met Gly Phe Asn Leu Thr Phe His Leu Ser Tyr Lys Phe Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Thr Leu Cys Leu Thr Val Val Gly Trp Ala Thr Ser Asn 
            20                  25                  30          


Tyr Phe Val Gly Ala Ile Gln Glu Ile Pro Lys Ala Lys Glu Phe Met 
        35                  40                  45              


Ala Asn Phe His Lys Thr Leu Ile Leu Gly Lys Gly Lys Thr Leu Thr 
    50                  55                  60                  


Asn Glu Ala Ser Thr Lys Lys Val Glu Leu Asp Asn Cys Pro Ser Val 
65                  70                  75                  80  


Ser Pro Tyr Leu Arg Gly Gln Ser Lys Leu Ile Phe Lys Pro Asp Leu 
                85                  90                  95      


Thr Leu Glu Glu Val Gln Ala Glu Asn Pro Lys Val Ser Arg Gly Arg 
            100                 105                 110         


Tyr Arg Pro Gln Glu Cys 
        115             


<210>  1368
<211>  136
<212>  PRT
<213>  Homo Sapiens

<400>  1368

Met Gly Phe Asn Leu Thr Phe His Leu Ser Tyr Lys Phe Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Thr Leu Cys Leu Thr Val Val Gly Trp Ala Thr Ser Asn 
            20                  25                  30          


Tyr Phe Val Gly Ala Ile Gln Glu Ile Pro Lys Ala Lys Glu Phe Met 
        35                  40                  45              


Ala Asn Phe His Lys Thr Leu Ile Leu Gly Lys Gly Lys Thr Leu Thr 
    50                  55                  60                  


Asn Glu Ala Ser Thr Lys Lys Val Glu Leu Asp Asn Cys Pro Ser Val 
65                  70                  75                  80  


Ser Pro Tyr Leu Arg Gly Gln Ser Lys Leu Ile Phe Lys Pro Asp Leu 
                85                  90                  95      


Thr Leu Glu Glu Val Gln Ala Glu Asn Pro Lys Val Ser Arg Gly Arg 
            100                 105                 110         


Tyr Arg Pro Gln Glu Cys Lys Ala Leu Gln Arg Val Ala Ile Leu Val 
        115                 120                 125             


Pro His Arg Asn Arg Glu Lys His 
    130                 135     


<210>  1369
<211>  246
<212>  PRT
<213>  Homo Sapiens

<400>  1369

Met Gly Phe Asn Leu Thr Phe His Leu Ser Tyr Lys Phe Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Thr Leu Cys Leu Thr Val Val Gly Trp Ala Thr Ser Asn 
            20                  25                  30          


Tyr Phe Val Gly Ala Ile Gln Glu Ile Pro Lys Ala Lys Glu Phe Met 
        35                  40                  45              


Ala Asn Phe His Lys Thr Leu Ile Leu Gly Lys Gly Lys Thr Leu Thr 
    50                  55                  60                  


Asn Glu Ala Ser Thr Lys Lys Val Glu Leu Asp Asn Cys Pro Ser Val 
65                  70                  75                  80  


Ser Pro Tyr Leu Arg Gly Gln Ser Lys Leu Ile Phe Lys Pro Asp Leu 
                85                  90                  95      


Thr Leu Glu Glu Val Gln Ala Glu Asn Pro Lys Val Ser Arg Gly Arg 
            100                 105                 110         


Tyr Arg Pro Gln Glu Cys Lys Ala Leu Gln Arg Val Ala Ile Leu Val 
        115                 120                 125             


Pro His Arg Asn Arg Glu Lys His Leu Met Tyr Leu Leu Glu His Leu 
    130                 135                 140                 


His Pro Phe Leu Gln Arg Gln Gln Leu Asp Tyr Gly Ile Tyr Val Ile 
145                 150                 155                 160 


His Gln Ala Glu Gly Lys Lys Phe Asn Arg Ala Lys Leu Leu Asn Val 
                165                 170                 175     


Gly Tyr Leu Glu Ala Leu Lys Glu Glu Asn Trp Asp Cys Phe Ile Phe 
            180                 185                 190         


His Asp Val Asp Leu Val Pro Glu Asn Asp Phe Asn Leu Tyr Lys Cys 
        195                 200                 205             


Glu Glu His Pro Lys His Leu Val Val Gly Arg Asn Ser Thr Gly Tyr 
    210                 215                 220                 


Arg Leu Arg Tyr Ser Gly Tyr Phe Gly Gly Val Thr Ala Leu Ser Arg 
225                 230                 235                 240 


Glu Gln Phe Phe Lys Gly 
                245     


<210>  1370
<211>  344
<212>  PRT
<213>  Homo Sapiens

<400>  1370

Met Gly Phe Asn Leu Thr Phe His Leu Ser Tyr Lys Phe Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Thr Leu Cys Leu Thr Val Val Gly Trp Ala Thr Ser Asn 
            20                  25                  30          


Tyr Phe Val Gly Ala Ile Gln Glu Ile Pro Lys Ala Lys Glu Phe Met 
        35                  40                  45              


Ala Asn Phe His Lys Thr Leu Ile Leu Gly Lys Gly Lys Thr Leu Thr 
    50                  55                  60                  


Asn Glu Ala Ser Thr Lys Lys Val Glu Leu Asp Asn Cys Pro Ser Val 
65                  70                  75                  80  


Ser Pro Tyr Leu Arg Gly Gln Ser Lys Leu Ile Phe Lys Pro Asp Leu 
                85                  90                  95      


Thr Leu Glu Glu Val Gln Ala Glu Asn Pro Lys Val Ser Arg Gly Arg 
            100                 105                 110         


Tyr Arg Pro Gln Glu Cys Lys Ala Leu Gln Arg Val Ala Ile Leu Val 
        115                 120                 125             


Pro His Arg Asn Arg Glu Lys His Leu Met Tyr Leu Leu Glu His Leu 
    130                 135                 140                 


His Pro Phe Leu Gln Arg Gln Gln Leu Asp Tyr Gly Ile Tyr Val Ile 
145                 150                 155                 160 


His Gln Ala Glu Gly Lys Lys Phe Asn Arg Ala Lys Leu Leu Asn Val 
                165                 170                 175     


Gly Tyr Leu Glu Ala Leu Lys Glu Glu Asn Trp Asp Cys Phe Ile Phe 
            180                 185                 190         


His Asp Val Asp Leu Val Pro Glu Asn Asp Phe Asn Leu Tyr Lys Cys 
        195                 200                 205             


Glu Glu His Pro Lys His Leu Val Val Gly Arg Asn Ser Thr Gly Tyr 
    210                 215                 220                 


Arg Leu Arg Tyr Ser Gly Tyr Phe Gly Gly Val Thr Ala Leu Ser Arg 
225                 230                 235                 240 


Glu Gln Phe Phe Lys Val Asn Gly Phe Ser Asn Asn Tyr Trp Gly Trp 
                245                 250                 255     


Gly Gly Glu Asp Asp Asp Leu Arg Leu Arg Val Glu Leu Gln Arg Met 
            260                 265                 270         


Lys Ile Ser Arg Pro Leu Pro Glu Val Gly Lys Tyr Thr Met Val Phe 
        275                 280                 285             


His Thr Arg Asp Lys Gly Asn Glu Val Asn Ala Glu Arg Met Lys Leu 
    290                 295                 300                 


Leu His Gln Val Ser Arg Val Trp Arg Thr Asp Gly Leu Ser Ser Cys 
305                 310                 315                 320 


Ser Tyr Lys Leu Val Ser Val Glu His Asn Pro Leu Tyr Ile Asn Ile 
                325                 330                 335     


Thr Val Asp Phe Trp Phe Gly Ala 
            340                 


<210>  1371
<211>  344
<212>  PRT
<213>  Homo Sapiens

<400>  1371

Met Gly Phe Asn Leu Thr Phe His Leu Ser Tyr Lys Phe Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Thr Leu Cys Leu Thr Val Val Gly Trp Ala Thr Ser Asn 
            20                  25                  30          


Tyr Phe Val Gly Ala Ile Gln Glu Ile Pro Lys Ala Lys Glu Phe Met 
        35                  40                  45              


Ala Asn Phe His Lys Thr Leu Ile Leu Gly Lys Gly Lys Thr Leu Thr 
    50                  55                  60                  


Asn Glu Ala Ser Thr Lys Lys Val Glu Leu Asp Asn Cys Pro Ser Val 
65                  70                  75                  80  


Ser Pro Tyr Leu Arg Gly Gln Ser Lys Leu Ile Phe Lys Pro Asp Leu 
                85                  90                  95      


Thr Leu Glu Glu Val Gln Ala Glu Asn Pro Lys Val Ser Arg Gly Arg 
            100                 105                 110         


Tyr Arg Pro Gln Glu Cys Lys Ala Leu Gln Arg Val Ala Ile Leu Val 
        115                 120                 125             


Pro His Arg Asn Arg Glu Lys His Leu Met Tyr Leu Leu Glu His Leu 
    130                 135                 140                 


His Pro Phe Leu Gln Arg Gln Gln Leu Asp Tyr Gly Ile Tyr Val Ile 
145                 150                 155                 160 


His Gln Ala Glu Gly Lys Lys Phe Asn Arg Ala Lys Leu Leu Asn Val 
                165                 170                 175     


Gly Tyr Leu Glu Ala Leu Lys Glu Glu Asn Trp Asp Cys Phe Ile Phe 
            180                 185                 190         


His Asp Val Asp Leu Val Pro Glu Asn Asp Phe Asn Leu Tyr Lys Cys 
        195                 200                 205             


Glu Glu His Pro Lys His Leu Val Val Gly Arg Asn Ser Thr Gly Tyr 
    210                 215                 220                 


Arg Leu Arg Tyr Ser Gly Tyr Phe Gly Gly Val Thr Ala Leu Ser Arg 
225                 230                 235                 240 


Glu Gln Phe Phe Lys Val Asn Gly Phe Ser Asn Asn Tyr Trp Gly Trp 
                245                 250                 255     


Gly Gly Glu Asp Asp Asp Leu Arg Leu Arg Val Glu Leu Gln Arg Met 
            260                 265                 270         


Lys Ile Ser Arg Pro Leu Pro Glu Val Gly Lys Tyr Thr Met Val Phe 
        275                 280                 285             


His Thr Arg Asp Lys Gly Asn Glu Val Asn Ala Glu Arg Met Lys Leu 
    290                 295                 300                 


Leu His Gln Val Ser Arg Val Trp Arg Thr Asp Gly Leu Ser Ser Cys 
305                 310                 315                 320 


Ser Tyr Lys Leu Val Ser Val Glu His Asn Pro Leu Tyr Ile Asn Ile 
                325                 330                 335     


Thr Val Asp Phe Trp Phe Gly Ala 
            340                 


<210>  1372
<211>  344
<212>  PRT
<213>  Homo Sapiens

<400>  1372

Met Gly Phe Asn Leu Thr Phe His Leu Ser Tyr Lys Phe Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Thr Leu Cys Leu Thr Val Val Gly Trp Ala Thr Ser Asn 
            20                  25                  30          


Tyr Phe Val Gly Ala Ile Gln Glu Ile Pro Lys Ala Lys Glu Phe Met 
        35                  40                  45              


Ala Asn Phe His Lys Thr Leu Ile Leu Gly Lys Gly Lys Thr Leu Thr 
    50                  55                  60                  


Asn Glu Ala Ser Thr Lys Lys Val Glu Leu Asp Asn Cys Pro Ser Val 
65                  70                  75                  80  


Ser Pro Tyr Leu Arg Gly Gln Ser Lys Leu Ile Phe Lys Pro Asp Leu 
                85                  90                  95      


Thr Leu Glu Glu Val Gln Ala Glu Asn Pro Lys Val Ser Arg Gly Arg 
            100                 105                 110         


Tyr Arg Pro Gln Glu Cys Lys Ala Leu Gln Arg Val Ala Ile Leu Val 
        115                 120                 125             


Pro His Arg Asn Arg Glu Lys His Leu Met Tyr Leu Leu Glu His Leu 
    130                 135                 140                 


His Pro Phe Leu Gln Arg Gln Gln Leu Asp Tyr Gly Ile Tyr Val Ile 
145                 150                 155                 160 


His Gln Ala Glu Gly Lys Lys Phe Asn Arg Ala Lys Leu Leu Asn Val 
                165                 170                 175     


Gly Tyr Leu Glu Ala Leu Lys Glu Glu Asn Trp Asp Cys Phe Ile Phe 
            180                 185                 190         


His Asp Val Asp Leu Val Pro Glu Asn Asp Phe Asn Leu Tyr Lys Cys 
        195                 200                 205             


Glu Glu His Pro Lys His Leu Val Val Gly Arg Asn Ser Thr Gly Tyr 
    210                 215                 220                 


Arg Leu Arg Tyr Ser Gly Tyr Phe Gly Gly Val Thr Ala Leu Ser Arg 
225                 230                 235                 240 


Glu Gln Phe Phe Lys Val Asn Gly Phe Ser Asn Asn Tyr Trp Gly Trp 
                245                 250                 255     


Gly Gly Glu Asp Asp Asp Leu Arg Leu Arg Val Glu Leu Gln Arg Met 
            260                 265                 270         


Lys Ile Ser Arg Pro Leu Pro Glu Val Gly Lys Tyr Thr Met Val Phe 
        275                 280                 285             


His Thr Arg Asp Lys Gly Asn Glu Val Asn Ala Glu Arg Met Lys Leu 
    290                 295                 300                 


Leu His Gln Val Ser Arg Val Trp Arg Thr Asp Gly Leu Ser Ser Cys 
305                 310                 315                 320 


Ser Tyr Lys Leu Val Ser Val Glu His Asn Pro Leu Tyr Ile Asn Ile 
                325                 330                 335     


Thr Val Asp Phe Trp Phe Gly Ala 
            340                 


<210>  1373
<211>  301
<212>  PRT
<213>  Homo Sapiens

<400>  1373

Met Gly Phe Asn Leu Thr Phe His Leu Ser Tyr Lys Phe Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Thr Leu Cys Leu Thr Val Val Gly Trp Ala Thr Ser Asn 
            20                  25                  30          


Tyr Phe Val Gly Ala Ile Gln Glu Ile Pro Lys Ala Lys Glu Phe Met 
        35                  40                  45              


Ala Asn Phe His Lys Thr Leu Ile Leu Gly Lys Gly Lys Thr Leu Thr 
    50                  55                  60                  


Asn Glu Ala Ser Thr Lys Lys Val Glu Leu Asp Asn Cys Pro Ser Val 
65                  70                  75                  80  


Ser Pro Tyr Leu Arg Gly Gln Ser Lys Leu Ile Phe Lys Pro Asp Leu 
                85                  90                  95      


Thr Leu Glu Glu Val Gln Ala Glu Asn Pro Lys Val Ser Arg Gly Arg 
            100                 105                 110         


Tyr Arg Pro Gln Glu Cys Lys Ala Leu Gln Arg Val Ala Ile Leu Val 
        115                 120                 125             


Pro His Arg Asn Arg Glu Lys His Leu Met Tyr Leu Leu Glu His Leu 
    130                 135                 140                 


His Pro Phe Leu Gln Arg Gln Gln Leu Asp Tyr Gly Ile Tyr Val Ile 
145                 150                 155                 160 


His Gln Ala Glu Gly Lys Lys Phe Asn Arg Ala Lys Leu Leu Asn Val 
                165                 170                 175     


Gly Tyr Leu Glu Ala Leu Lys Glu Glu Asn Trp Asp Cys Phe Ile Phe 
            180                 185                 190         


His Asp Val Asp Leu Val Pro Glu Asn Asp Phe Asn Leu Tyr Lys Cys 
        195                 200                 205             


Glu Glu His Pro Lys His Leu Val Val Gly Arg Asn Ser Thr Gly Tyr 
    210                 215                 220                 


Arg Leu Arg Tyr Ser Gly Tyr Phe Gly Gly Val Thr Ala Leu Ser Arg 
225                 230                 235                 240 


Glu Gln Phe Phe Lys Val Asn Gly Phe Ser Asn Asn Tyr Trp Gly Trp 
                245                 250                 255     


Gly Gly Glu Asp Asp Asp Leu Arg Leu Arg Val Glu Leu Gln Arg Met 
            260                 265                 270         


Lys Ile Ser Arg Pro Leu Pro Glu Val Gly Lys Tyr Thr Met Val Phe 
        275                 280                 285             


His Thr Arg Asp Lys Gly Asn Glu Val Asn Ala Glu Arg 
    290                 295                 300     


<210>  1374
<211>  25
<212>  PRT
<213>  Homo Sapiens

<400>  1374

Met Tyr Leu Leu Glu His Leu His Pro Phe Leu Gln Arg Gln Gln Leu 
1               5                   10                  15      


Asp Tyr Gly Ile Tyr Val Ile His Gln 
            20                  25  


<210>  1375
<211>  388
<212>  PRT
<213>  Homo Sapiens

<400>  1375

Met Arg Ala Arg Arg Gly Leu Leu Arg Leu Pro Arg Arg Ser Leu Leu 
1               5                   10                  15      


Ala Ala Leu Phe Phe Phe Ser Leu Ser Ser Ser Leu Leu Tyr Phe Val 
            20                  25                  30          


Tyr Val Ala Pro Gly Ile Val Asn Thr Tyr Leu Phe Met Met Gln Ala 
        35                  40                  45              


Gln Gly Ile Leu Ile Arg Asp Asn Val Arg Thr Ile Gly Ala Gln Val 
    50                  55                  60                  


Tyr Glu Gln Val Leu Arg Ser Ala Tyr Ala Lys Arg Asn Ser Ser Val 
65                  70                  75                  80  


Asn Asp Ser Asp Tyr Pro Leu Asp Leu Asn His Ser Glu Thr Phe Leu 
                85                  90                  95      


Gln Thr Thr Thr Phe Leu Pro Glu Asp Phe Thr Tyr Phe Ala Asn His 
            100                 105                 110         


Thr Cys Pro Glu Arg Leu Pro Ser Met Lys Gly Pro Ile Asp Ile Asn 
        115                 120                 125             


Met Ser Glu Ile Gly Met Asp Tyr Ile His Glu Leu Phe Ser Lys Asp 
    130                 135                 140                 


Pro Thr Ile Lys Leu Gly Gly His Trp Lys Pro Ser Asp Cys Met Pro 
145                 150                 155                 160 


Arg Trp Lys Val Ala Ile Leu Ile Pro Phe Arg Asn Arg His Glu His 
                165                 170                 175     


Leu Pro Val Leu Phe Arg His Leu Leu Pro Met Leu Gln Arg Gln Arg 
            180                 185                 190         


Leu Gln Phe Ala Phe Tyr Val Val Glu Gln Val Gly Thr Gln Pro Phe 
        195                 200                 205             


Asn Arg Ala Met Leu Phe Asn Val Gly Phe Gln Glu Ala Met Lys Asp 
    210                 215                 220                 


Leu Asp Trp Asp Cys Leu Ile Phe His Asp Val Asp His Ile Pro Glu 
225                 230                 235                 240 


Ser Asp Arg Asn Tyr Tyr Gly Cys Gly Gln Met Pro Arg His Phe Ala 
                245                 250                 255     


Thr Lys Leu Asp Lys Tyr Met Tyr Leu Leu Pro Tyr Thr Glu Phe Phe 
            260                 265                 270         


Gly Gly Val Ser Gly Leu Thr Val Glu Gln Phe Arg Lys Ile Asn Gly 
        275                 280                 285             


Phe Pro Asn Ala Phe Trp Gly Trp Gly Gly Glu Asp Asp Asp Leu Trp 
    290                 295                 300                 


Asn Arg Val Gln Asn Ala Gly Tyr Ser Val Ser Arg Pro Glu Gly Asp 
305                 310                 315                 320 


Thr Gly Lys Tyr Lys Ser Ile Pro His His His Arg Gly Glu Val Gln 
                325                 330                 335     


Phe Leu Gly Arg Tyr Ala Leu Leu Arg Lys Ser Lys Glu Arg Gln Gly 
            340                 345                 350         


Leu Asp Gly Leu Asn Asn Leu Asn Tyr Phe Ala Asn Ile Thr Tyr Asp 
        355                 360                 365             


Ala Leu Tyr Lys Asn Ile Thr Val Asn Leu Thr Pro Glu Leu Ala Gln 
    370                 375                 380                 


Val Asn Glu Tyr 
385             


<210>  1376
<211>  343
<212>  PRT
<213>  Homo Sapiens

<400>  1376

Met Ser Val Leu Arg Arg Met Met Arg Val Ser Asn Arg Ser Leu Leu 
1               5                   10                  15      


Ala Phe Ile Phe Phe Phe Ser Leu Ser Ser Ser Cys Leu Tyr Phe Ile 
            20                  25                  30          


Tyr Val Ala Pro Gly Ile Ala Asn Thr Tyr Leu Phe Met Val Gln Ala 
        35                  40                  45              


Arg Gly Ile Met Leu Arg Glu Asn Val Lys Thr Ile Gly His Met Ile 
    50                  55                  60                  


Arg Leu Tyr Thr Asn Lys Asn Ser Thr Leu Asn Gly Thr Asp Tyr Pro 
65                  70                  75                  80  


Glu Gly Asn Asn Ser Ser Asp Tyr Leu Val Gln Thr Thr Thr Tyr Leu 
                85                  90                  95      


Pro Glu Asn Phe Thr Tyr Ser Pro Tyr Leu Pro Cys Pro Glu Lys Leu 
            100                 105                 110         


Pro Tyr Met Arg Gly Phe Leu Asn Val Asn Val Ser Glu Val Ser Phe 
        115                 120                 125             


Asp Glu Ile His Gln Leu Phe Ser Lys Asp Leu Asp Ile Glu Pro Gly 
    130                 135                 140                 


Gly His Trp Arg Pro Lys Asp Cys Lys Pro Arg Trp Lys Thr Gly Thr 
145                 150                 155                 160 


Gln Pro Phe Asn Arg Ala Met Leu Phe Asn Val Gly Phe Lys Glu Ala 
                165                 170                 175     


Met Lys Asp Ser Val Trp Asp Cys Val Ile Phe His Asp Val Asp His 
            180                 185                 190         


Leu Pro Glu Asn Asp Arg Asn Tyr Tyr Gly Cys Gly Glu Met Pro Arg 
        195                 200                 205             


His Phe Ala Ala Lys Leu Asp Lys Tyr Met Tyr Ile Leu Pro Tyr Lys 
    210                 215                 220                 


Glu Phe Phe Gly Gly Val Ser Gly Leu Thr Val Glu Gln Phe Arg Lys 
225                 230                 235                 240 


Ile Asn Gly Phe Pro Asn Ala Phe Trp Gly Trp Gly Gly Glu Asp Asp 
                245                 250                 255     


Asp Leu Trp Asn Arg Val His Tyr Ala Gly Tyr Asn Val Thr Arg Pro 
            260                 265                 270         


Glu Gly Asp Leu Gly Lys Tyr Lys Ser Ile Pro His His His Arg Gly 
        275                 280                 285             


Glu Val Gln Phe Leu Gly Arg Tyr Lys Leu Leu Arg Tyr Ser Lys Glu 
    290                 295                 300                 


Arg Gln Tyr Ile Asp Gly Leu Asn Asn Leu Ile Tyr Arg Pro Lys Ile 
305                 310                 315                 320 


Leu Val Asp Arg Leu Tyr Thr Asn Ile Ser Val Asn Leu Met Pro Glu 
                325                 330                 335     


Leu Ala Pro Ile Glu Asp Tyr 
            340             


<210>  1377
<211>  382
<212>  PRT
<213>  Homo Sapiens

<400>  1377

Met Ser Val Leu Arg Arg Met Met Arg Val Ser Asn Arg Ser Leu Leu 
1               5                   10                  15      


Ala Phe Ile Phe Phe Phe Ser Leu Ser Ser Ser Cys Leu Tyr Phe Ile 
            20                  25                  30          


Tyr Val Ala Pro Gly Ile Ala Asn Thr Tyr Leu Phe Met Val Gln Ala 
        35                  40                  45              


Arg Gly Ile Met Leu Arg Glu Asn Val Lys Thr Ile Gly His Met Ile 
    50                  55                  60                  


Arg Leu Tyr Thr Asn Lys Asn Ser Thr Leu Asn Gly Thr Asp Tyr Pro 
65                  70                  75                  80  


Glu Gly Asn Asn Ser Ser Asp Tyr Leu Val Gln Thr Thr Thr Tyr Leu 
                85                  90                  95      


Pro Glu Asn Phe Thr Tyr Ser Pro Tyr Leu Pro Cys Pro Glu Lys Leu 
            100                 105                 110         


Pro Tyr Met Arg Gly Phe Leu Asn Val Asn Val Ser Glu Val Ser Phe 
        115                 120                 125             


Asp Glu Ile His Gln Leu Phe Ser Lys Asp Leu Asp Ile Glu Pro Gly 
    130                 135                 140                 


Gly His Trp Arg Pro Lys Asp Cys Lys Pro Arg Trp Lys Val Ala Val 
145                 150                 155                 160 


Leu Ile Pro Phe Arg Asn Arg His Glu His Leu Pro Ile Phe Phe Leu 
                165                 170                 175     


His Leu Ile Pro Met Leu Gln Lys Gln Arg Leu Glu Phe Ala Phe Tyr 
            180                 185                 190         


Val Ile Glu Gln Thr Gly Thr Gln Pro Phe Asn Arg Ala Met Leu Phe 
        195                 200                 205             


Asn Val Gly Phe Lys Glu Ala Met Lys Asp Ser Val Trp Asp Cys Val 
    210                 215                 220                 


Ile Phe His Asp Val Asp His Leu Pro Glu Asn Asp Arg Asn Tyr Tyr 
225                 230                 235                 240 


Gly Cys Gly Glu Met Pro Arg His Phe Ala Ala Lys Leu Asp Lys Tyr 
                245                 250                 255     


Met Tyr Ile Leu Pro Tyr Lys Glu Phe Phe Gly Gly Val Ser Gly Leu 
            260                 265                 270         


Thr Val Glu Gln Phe Arg Lys Ile Asn Gly Phe Pro Asn Ala Phe Trp 
        275                 280                 285             


Gly Trp Gly Gly Glu Asp Asp Asp Leu Trp Asn Arg Val His Tyr Ala 
    290                 295                 300                 


Gly Tyr Asn Val Thr Arg Pro Glu Gly Asp Leu Gly Lys Tyr Lys Ser 
305                 310                 315                 320 


Ile Pro His His His Arg Gly Glu Val Gln Phe Leu Gly Arg Tyr Lys 
                325                 330                 335     


Leu Leu Arg Tyr Ser Lys Glu Arg Gln Tyr Ile Asp Gly Leu Asn Asn 
            340                 345                 350         


Leu Ile Tyr Arg Pro Lys Ile Leu Val Asp Arg Leu Tyr Thr Asn Ile 
        355                 360                 365             


Ser Val Asn Leu Met Pro Glu Leu Ala Pro Ile Glu Asp Tyr 
    370                 375                 380         


<210>  1378
<211>  343
<212>  PRT
<213>  Homo Sapiens

<400>  1378

Met Ser Val Leu Arg Arg Met Met Arg Val Ser Asn Arg Ser Leu Leu 
1               5                   10                  15      


Ala Phe Ile Phe Phe Phe Ser Leu Ser Ser Ser Cys Leu Tyr Phe Ile 
            20                  25                  30          


Tyr Val Ala Pro Gly Ile Asp Tyr Pro Glu Gly Asn Asn Ser Ser Asp 
        35                  40                  45              


Tyr Leu Val Gln Thr Thr Thr Tyr Leu Pro Glu Asn Phe Thr Tyr Ser 
    50                  55                  60                  


Pro Tyr Leu Pro Cys Pro Glu Lys Leu Pro Tyr Met Arg Gly Phe Leu 
65                  70                  75                  80  


Asn Val Asn Val Ser Glu Val Ser Phe Asp Glu Ile His Gln Leu Phe 
                85                  90                  95      


Ser Lys Asp Leu Asp Ile Glu Pro Gly Gly His Trp Arg Pro Lys Asp 
            100                 105                 110         


Cys Lys Pro Arg Trp Lys Val Ala Val Leu Ile Pro Phe Arg Asn Arg 
        115                 120                 125             


His Glu His Leu Pro Ile Phe Phe Leu His Leu Ile Pro Met Leu Gln 
    130                 135                 140                 


Lys Gln Arg Leu Glu Phe Ala Phe Tyr Val Ile Glu Gln Thr Gly Thr 
145                 150                 155                 160 


Gln Pro Phe Asn Arg Ala Met Leu Phe Asn Val Gly Phe Lys Glu Ala 
                165                 170                 175     


Met Lys Asp Ser Val Trp Asp Cys Val Ile Phe His Asp Val Asp His 
            180                 185                 190         


Leu Pro Glu Asn Asp Arg Asn Tyr Tyr Gly Cys Gly Glu Met Pro Arg 
        195                 200                 205             


His Phe Ala Ala Lys Leu Asp Lys Tyr Met Tyr Ile Leu Pro Tyr Lys 
    210                 215                 220                 


Glu Phe Phe Gly Gly Val Ser Gly Leu Thr Val Glu Gln Phe Arg Lys 
225                 230                 235                 240 


Ile Asn Gly Phe Pro Asn Ala Phe Trp Gly Trp Gly Gly Glu Asp Asp 
                245                 250                 255     


Asp Leu Trp Asn Arg Val His Tyr Ala Gly Tyr Asn Val Thr Arg Pro 
            260                 265                 270         


Glu Gly Asp Leu Gly Lys Tyr Lys Ser Ile Pro His His His Arg Gly 
        275                 280                 285             


Glu Val Gln Phe Leu Gly Arg Tyr Lys Leu Leu Arg Tyr Ser Lys Glu 
    290                 295                 300                 


Arg Gln Tyr Ile Asp Gly Leu Asn Asn Leu Ile Tyr Arg Pro Lys Ile 
305                 310                 315                 320 


Leu Val Asp Arg Leu Tyr Thr Asn Ile Ser Val Asn Leu Met Pro Glu 
                325                 330                 335     


Leu Ala Pro Ile Glu Asp Tyr 
            340             


<210>  1379
<211>  72
<212>  PRT
<213>  Homo Sapiens

<400>  1379

Met Val Gln Ala Arg Gly Ile Met Leu Arg Glu Asn Val Lys Thr Ile 
1               5                   10                  15      


Gly His Met Ile Arg Leu Tyr Thr Asn Lys Asn Ser Thr Leu Asn Gly 
            20                  25                  30          


Thr Asp Tyr Pro Glu Gly Asn Asn Ser Ser Asp Tyr Leu Val Gln Thr 
        35                  40                  45              


Thr Thr Tyr Leu Pro Glu Asn Phe Thr Tyr Ser Pro Tyr Leu Pro Cys 
    50                  55                  60                  


Pro Glu Lys Leu Pro Tyr Met Arg 
65                  70          


<210>  1380
<211>  415
<212>  PRT
<213>  Homo Sapiens

<400>  1380

Met Gln Met Ser Tyr Ala Ile Arg Cys Ala Phe Tyr Gln Leu Leu Leu 
1               5                   10                  15      


Ala Ala Leu Met Leu Val Ala Met Leu Gln Leu Leu Tyr Leu Ser Leu 
            20                  25                  30          


Leu Ser Gly Leu His Gly Gln Glu Glu Gln Asp Gln Tyr Phe Glu Phe 
        35                  40                  45              


Phe Pro Pro Ser Pro Arg Ser Val Asp Gln Val Lys Ala Gln Leu Arg 
    50                  55                  60                  


Thr Ala Leu Ala Ser Gly Gly Val Leu Asp Ala Ser Gly Asp Tyr Arg 
65                  70                  75                  80  


Val Tyr Arg Gly Leu Leu Lys Thr Thr Met Asp Pro Asn Asp Val Ile 
                85                  90                  95      


Leu Ala Thr His Ala Ser Val Asp Asn Leu Leu His Leu Ser Gly Leu 
            100                 105                 110         


Leu Glu Arg Trp Glu Gly Pro Leu Ser Val Ser Val Phe Ala Ala Thr 
        115                 120                 125             


Lys Glu Glu Ala Gln Leu Ala Thr Val Leu Ala Tyr Ala Leu Ser Ser 
    130                 135                 140                 


His Cys Pro Asp Met Arg Ala Arg Val Ala Met His Leu Val Cys Pro 
145                 150                 155                 160 


Ser Arg Tyr Glu Ala Ala Val Pro Asp Pro Arg Glu Pro Gly Glu Phe 
                165                 170                 175     


Ala Leu Leu Arg Ser Cys Gln Glu Val Phe Asp Lys Leu Ala Arg Val 
            180                 185                 190         


Ala Gln Pro Gly Ile Asn Tyr Ala Leu Gly Thr Asn Val Ser Tyr Pro 
        195                 200                 205             


Asn Asn Leu Leu Arg Asn Leu Ala Arg Glu Gly Ala Asn Tyr Ala Leu 
    210                 215                 220                 


Val Ile Asp Val Asp Met Val Pro Ser Glu Gly Leu Trp Arg Gly Leu 
225                 230                 235                 240 


Arg Glu Met Leu Asp Gln Ser Asn Gln Trp Gly Gly Thr Ala Leu Val 
                245                 250                 255     


Val Pro Ala Phe Glu Ile Arg Arg Ala Arg Arg Met Pro Met Asn Lys 
            260                 265                 270         


Asn Glu Leu Val Gln Leu Tyr Gln Val Gly Glu Val Arg Pro Phe Tyr 
        275                 280                 285             


Tyr Gly Leu Cys Thr Pro Cys Gln Ala Pro Thr Asn Tyr Ser Arg Trp 
    290                 295                 300                 


Val Asn Leu Pro Glu Glu Ser Leu Leu Arg Pro Ala Tyr Val Val Pro 
305                 310                 315                 320 


Trp Gln Asp Pro Trp Glu Pro Phe Tyr Val Ala Gly Gly Lys Val Pro 
                325                 330                 335     


Thr Phe Asp Glu Arg Phe Arg Gln Tyr Gly Phe Asn Arg Ile Ser Gln 
            340                 345                 350         


Ala Cys Glu Leu His Val Ala Gly Phe Asp Phe Glu Val Leu Asn Glu 
        355                 360                 365             


Gly Phe Leu Val His Lys Gly Phe Lys Glu Ala Leu Lys Phe His Pro 
    370                 375                 380                 


Gln Lys Glu Ala Glu Asn Gln His Asn Lys Ile Leu Tyr Arg Gln Phe 
385                 390                 395                 400 


Lys Gln Glu Leu Lys Ala Lys Tyr Pro Asn Ser Pro Arg Arg Cys 
                405                 410                 415 


<210>  1381
<211>  92
<212>  PRT
<213>  Homo Sapiens

<400>  1381

Ile Asp Val Thr Phe Lys Ser Thr Asn Pro Tyr Gly Trp Pro Gln Ile 
1               5                   10                  15      


Val Leu Ser Val Tyr Gly Pro Asp Val Phe Gly Asn Asp Val Val Arg 
            20                  25                  30          


Gly Tyr Gly Ala Val His Val Pro Phe Ser Pro Gly Arg His Lys Arg 
        35                  40                  45              


Thr Ile Pro Met Phe Val Pro Glu Ser Thr Ser Lys Leu Gln Lys Phe 
    50                  55                  60                  


Thr Ser Trp Phe Met Gly Arg Arg Pro Glu Tyr Thr Asp Pro Lys Val 
65                  70                  75                  80  


Val Ala Gln Gly Glu Gly Arg Glu Ala Gln Pro Gly 
                85                  90          


<210>  1382
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  1382

Leu Leu Met Val Asn Gly Gln Val Glu Ser Ala Gln Phe Pro Glu Tyr 
1               5                   10                  15      


Asp Asp Leu Tyr Cys Lys Tyr Cys Phe Val Tyr Gly Gln Asp Trp Ala 
            20                  25                  30          


Pro Thr Ala Gly Leu Glu Glu Gly Ile Ser Gln Ile Thr Ser Lys Ser 
        35                  40                  45              


Gln Asp Val Arg Gln Ala Leu Val Trp Asn Phe Pro Ile Asp Val Thr 
    50                  55                  60                  


Phe Lys Ser Thr Asn Pro Tyr Gly Trp Pro Gln Ile Val Leu Ser Val 
65                  70                  75                  80  


Tyr Gly Pro Asp Val Phe Gly Asn Asp Val Val Arg Gly Tyr Gly Ala 
                85                  90                  95      


Val His Val Pro Phe Ser Pro Gly Arg His Lys Arg Thr Ile Pro Met 
            100                 105                 110         


Phe Val Pro Glu Ser Thr Ser Lys Leu Gln Lys Phe Thr Arg Ser Ala 
        115                 120                 125             


Ser Cys Ser Thr His 
    130             


<210>  1383
<211>  135
<212>  PRT
<213>  Homo Sapiens

<400>  1383

Met Ala Thr Ala Ser Pro Ser Val Phe Leu Leu Met Val Asn Gly Gln 
1               5                   10                  15      


Val Glu Ser Ala Gln Phe Pro Glu Tyr Asp Asp Leu Tyr Cys Lys Tyr 
            20                  25                  30          


Cys Phe Val Tyr Gly Gln Asp Trp Ala Pro Thr Ala Gly Leu Glu Glu 
        35                  40                  45              


Gly Ile Ser Gln Ile Thr Ser Lys Ser Gln Asp Val Arg Gln Ala Leu 
    50                  55                  60                  


Val Trp Asn Phe Pro Ile Asp Val Thr Phe Lys Ser Thr Asn Pro Tyr 
65                  70                  75                  80  


Gly Trp Pro Gln Ile Val Leu Ser Val Tyr Gly Pro Asp Val Phe Gly 
                85                  90                  95      


Asn Asp Val Val Arg Gly Tyr Gly Ala Val His Val Pro Phe Ser Pro 
            100                 105                 110         


Gly Arg His Lys Arg Thr Ile Pro Met Phe Val Pro Glu Ser Thr Ser 
        115                 120                 125             


Lys Leu Gln Lys Phe Thr Arg 
    130                 135 


<210>  1384
<211>  153
<212>  PRT
<213>  Homo Sapiens

<400>  1384

Met Ala Thr Ala Ser Pro Ser Val Phe Leu Leu Met Val Asn Gly Gln 
1               5                   10                  15      


Val Glu Ser Ala Gln Phe Pro Glu Tyr Asp Asp Leu Tyr Cys Lys Tyr 
            20                  25                  30          


Cys Phe Val Tyr Gly Gln Asp Trp Ala Pro Thr Ala Gly Leu Glu Glu 
        35                  40                  45              


Gly Ile Ser Gln Ile Thr Ser Lys Ser Gln Asp Val Arg Gln Ala Leu 
    50                  55                  60                  


Val Trp Asn Phe Pro Ile Asp Val Thr Phe Lys Ser Thr Asn Pro Tyr 
65                  70                  75                  80  


Gly Trp Pro Gln Ile Val Leu Ser Val Tyr Gly Pro Asp Val Phe Gly 
                85                  90                  95      


Asn Asp Val Val Arg Gly Tyr Gly Ala Val His Val Pro Phe Ser Pro 
            100                 105                 110         


Gly Arg His Lys Arg Thr Ile Pro Met Phe Val Pro Glu Ser Thr Ser 
        115                 120                 125             


Lys Leu Gln Lys Phe Thr Ser Leu Cys Leu Val Ala Ser Ser Asp Leu 
    130                 135                 140                 


Gln Ala Ala Pro Pro Thr Glu Asp Lys 
145                 150             


<210>  1385
<211>  186
<212>  PRT
<213>  Homo Sapiens

<400>  1385

Met Ala Thr Ala Ser Pro Ser Val Phe Leu Leu Met Val Asn Gly Gln 
1               5                   10                  15      


Val Glu Ser Ala Gln Phe Pro Glu Tyr Asp Asp Leu Tyr Cys Lys Tyr 
            20                  25                  30          


Cys Phe Val Tyr Gly Gln Asp Trp Ala Pro Thr Ala Gly Leu Glu Glu 
        35                  40                  45              


Gly Ile Ser Gln Ile Thr Ser Lys Ser Gln Asp Val Arg Gln Ala Leu 
    50                  55                  60                  


Val Trp Asn Phe Pro Ile Asp Val Thr Phe Lys Ser Thr Asn Pro Tyr 
65                  70                  75                  80  


Gly Trp Pro Gln Ile Val Leu Ser Val Tyr Gly Pro Asp Val Phe Gly 
                85                  90                  95      


Asn Asp Val Val Arg Gly Tyr Gly Ala Val His Val Pro Phe Ser Pro 
            100                 105                 110         


Gly Arg His Lys Arg Thr Ile Pro Met Phe Val Pro Glu Ser Thr Ser 
        115                 120                 125             


Lys Leu Gln Lys Phe Thr Ser Trp Phe Met Gly Arg Arg Pro Glu Tyr 
    130                 135                 140                 


Thr Asp Pro Lys Val Val Ala Gln Gly Glu Gly Arg Glu Ala Ile Thr 
145                 150                 155                 160 


Ala Pro Arg Lys Ala Val Phe Ser Val His Gly Leu Thr Ser Pro Arg 
                165                 170                 175     


Ala Leu Ala Leu Val His Ile Lys Gly Thr 
            180                 185     


<210>  1386
<211>  161
<212>  PRT
<213>  Homo Sapiens

<400>  1386

Met Ala Thr Ala Ser Pro Ser Val Phe Leu Leu Met Val Asn Gly Gln 
1               5                   10                  15      


Val Glu Ser Ala Gln Phe Pro Glu Tyr Asp Asp Leu Tyr Cys Lys Tyr 
            20                  25                  30          


Cys Phe Val Tyr Gly Gln Asp Trp Ala Pro Thr Ala Gly Leu Glu Glu 
        35                  40                  45              


Gly Ile Ser Gln Ile Thr Ser Lys Ser Gln Asp Val Arg Gln Ala Leu 
    50                  55                  60                  


Val Trp Asn Phe Pro Ile Asp Val Thr Phe Lys Ser Thr Asn Pro Tyr 
65                  70                  75                  80  


Gly Trp Pro Gln Ile Val Leu Ser Val Tyr Gly Pro Asp Val Phe Gly 
                85                  90                  95      


Asn Asp Val Val Arg Gly Tyr Gly Ala Val His Val Pro Phe Ser Pro 
            100                 105                 110         


Gly Arg His Lys Arg Thr Ile Pro Met Phe Val Pro Glu Ser Thr Ser 
        115                 120                 125             


Lys Leu Gln Lys Phe Thr Ser Trp Phe Met Gly Arg Arg Pro Glu Tyr 
    130                 135                 140                 


Thr Asp Pro Lys Val Val Ala Gln Gly Glu Gly Arg Glu Ala Gln Pro 
145                 150                 155                 160 


Gly 
    


<210>  1387
<211>  187
<212>  PRT
<213>  Homo Sapiens

<400>  1387

Met Ala Thr Ala Ser Pro Ser Val Phe Leu Leu Met Val Asn Gly Gln 
1               5                   10                  15      


Val Glu Ser Ala Gln Phe Pro Glu Tyr Asp Asp Leu Tyr Cys Lys Tyr 
            20                  25                  30          


Cys Phe Val Tyr Gly Gln Asp Trp Ala Pro Thr Ala Gly Leu Glu Glu 
        35                  40                  45              


Gly Ile Ser Gln Ile Thr Ser Lys Ser Gln Asp Val Arg Gln Ala Leu 
    50                  55                  60                  


Val Trp Asn Phe Pro Ile Asp Val Thr Phe Lys Ser Thr Asn Pro Tyr 
65                  70                  75                  80  


Gly Trp Pro Gln Ile Val Leu Ser Val Tyr Gly Pro Asp Val Phe Gly 
                85                  90                  95      


Asn Asp Val Val Arg Gly Tyr Gly Ala Val His Val Pro Phe Ser Pro 
            100                 105                 110         


Gly Arg His Lys Arg Thr Ile Pro Met Phe Val Pro Glu Ser Thr Ser 
        115                 120                 125             


Lys Leu Gln Lys Phe Thr Ser Trp Phe Met Gly Arg Arg Pro Glu Tyr 
    130                 135                 140                 


Thr Asp Pro Lys Val Val Ala Gln Gly Glu Gly Arg Glu Asp Glu Asn 
145                 150                 155                 160 


Ala Glu Ala Glu Ile Pro Arg Ser Thr Trp Val Ser Leu Cys Pro Ser 
                165                 170                 175     


Pro Ala Trp Leu Met Leu Pro Phe Cys Pro Gln 
            180                 185         


<210>  1388
<211>  183
<212>  PRT
<213>  Homo Sapiens

<400>  1388

Met Ala Thr Ala Ser Pro Ser Val Phe Leu Leu Met Val Asn Gly Gln 
1               5                   10                  15      


Val Glu Ser Ala Gln Phe Pro Glu Tyr Asp Asp Leu Tyr Cys Lys Tyr 
            20                  25                  30          


Cys Phe Val Tyr Gly Gln Asp Trp Ala Pro Thr Ala Gly Leu Glu Glu 
        35                  40                  45              


Gly Ile Ser Gln Ile Thr Ser Lys Ser Gln Asp Val Arg Gln Ala Leu 
    50                  55                  60                  


Val Trp Asn Phe Pro Ile Asp Val Thr Phe Lys Ser Thr Asn Pro Tyr 
65                  70                  75                  80  


Gly Trp Pro Gln Ile Val Leu Ser Val Tyr Gly Pro Asp Val Phe Gly 
                85                  90                  95      


Asn Asp Val Val Arg Gly Tyr Gly Ala Val His Val Pro Phe Ser Pro 
            100                 105                 110         


Gly Arg His Lys Arg Thr Ile Pro Met Phe Val Pro Glu Ser Thr Ser 
        115                 120                 125             


Lys Leu Gln Lys Phe Thr Ser Trp Phe Met Gly Arg Arg Pro Glu Tyr 
    130                 135                 140                 


Thr Asp Pro Lys Val Val Ala Gln Gly Glu Gly Arg Glu Gly Lys Ala 
145                 150                 155                 160 


Pro Ser Pro Leu Leu Pro Pro Ser Pro Ile Gln Val Thr Ala Trp Glu 
                165                 170                 175     


Trp Val Gly Pro Gly Leu Gly 
            180             


<210>  1389
<211>  204
<212>  PRT
<213>  Homo Sapiens

<400>  1389

Met Ala Thr Ala Ser Pro Ser Val Phe Leu Leu Met Val Asn Gly Gln 
1               5                   10                  15      


Val Glu Ser Ala Gln Phe Pro Glu Tyr Asp Asp Leu Tyr Cys Lys Tyr 
            20                  25                  30          


Cys Phe Val Tyr Gly Gln Asp Trp Ala Pro Thr Ala Gly Leu Glu Glu 
        35                  40                  45              


Gly Ile Ser Gln Ile Thr Ser Lys Ser Gln Asp Val Arg Gln Ala Leu 
    50                  55                  60                  


Val Trp Asn Phe Pro Ile Asp Val Thr Phe Lys Ser Thr Asn Pro Tyr 
65                  70                  75                  80  


Gly Trp Pro Gln Ile Val Leu Ser Val Tyr Gly Pro Asp Val Phe Gly 
                85                  90                  95      


Asn Asp Val Val Arg Gly Tyr Gly Ala Val His Val Pro Phe Ser Pro 
            100                 105                 110         


Gly Arg His Lys Arg Thr Ile Pro Met Phe Val Pro Glu Ser Thr Ser 
        115                 120                 125             


Lys Leu Gln Lys Phe Thr Ser Trp Phe Met Gly Arg Arg Pro Glu Tyr 
    130                 135                 140                 


Thr Asp Pro Lys Val Val Ala Gln Gly Glu Gly Arg Glu Val Thr Arg 
145                 150                 155                 160 


Val Arg Ser Gln Gly Phe Val Thr Leu Leu Phe Asn Val Val Thr Lys 
                165                 170                 175     


Asp Met Arg Lys Leu Gly Tyr Asp Thr Gly Pro Ser Asp Thr Gln Gly 
            180                 185                 190         


Val Leu Gly Pro Ser Pro Pro Gln Ser Phe Pro Gln 
        195                 200                 


<210>  1390
<211>  125
<212>  PRT
<213>  Homo Sapiens

<400>  1390

Met Ala Thr Ala Ser Pro Ser Val Phe Leu Leu Met Val Asn Gly Gln 
1               5                   10                  15      


Val Glu Ser Ala Gln Phe Pro Glu Tyr Asp Asp Leu Tyr Cys Lys Tyr 
            20                  25                  30          


Cys Phe Val Tyr Gly Gln Asp Trp Ala Pro Thr Ala Gly Leu Glu Glu 
        35                  40                  45              


Gly Ile Ser Gln Ile Thr Ser Lys Ser Gln Asp Val Arg Gln Ala Leu 
    50                  55                  60                  


Val Trp Asn Phe Pro Ile Asp Val Thr Phe Lys Ser Thr Asn Pro Tyr 
65                  70                  75                  80  


Gly Tyr Arg Ala Gln Arg Val Trp Thr Arg Cys Val Arg Glu Arg Cys 
                85                  90                  95      


Gly Ser Arg Leu Trp Gly Arg Ala Arg Ala Leu Leu Thr Trp Pro Ala 
            100                 105                 110         


Gln Lys Asp His Pro His Val Cys Pro Arg Ile Tyr Val 
        115                 120                 125 


<210>  1391
<211>  19
<212>  PRT
<213>  Homo Sapiens

<400>  1391

Met Met Thr Ser Thr Ala Ser Thr Ala Leu Cys Thr Ala Arg Thr Gly 
1               5                   10                  15      


Pro Pro Gln 
            


<210>  1392
<211>  106
<212>  PRT
<213>  Homo Sapiens

<400>  1392

Met Met Thr Ser Thr Ala Ser Thr Ala Leu Cys Thr Ala Arg Thr Gly 
1               5                   10                  15      


Pro Pro Gln Arg Val Trp Arg Arg Gly Ser His Arg Ser His Pro Arg 
            20                  25                  30          


Ala Lys Met Cys Gly Lys His Trp Cys Gly Thr Ser Pro Leu Met Ser 
        35                  40                  45              


Pro Leu Lys Ala Pro Thr Pro Thr Ala Gly His Arg Ser Cys Ser Ala 
    50                  55                  60                  


Cys Met Asp Gln Met Cys Ser Gly Thr Met Trp Phe Glu Ala Met Gly 
65                  70                  75                  80  


Pro Cys Thr Cys Pro Ser His Leu Ala Gly Thr Lys Gly Pro Ser Pro 
                85                  90                  95      


Cys Leu Ser Gln Asn Leu Arg Leu Asn Cys 
            100                 105     


<210>  1393
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  1393

Met Met Thr Ser Thr Ala Ser Thr Ala Leu Cys Thr Ala Arg Thr Gly 
1               5                   10                  15      


Pro Pro Gln Arg Val Trp Arg Arg Gly Ser His Arg Ser His Pro Arg 
            20                  25                  30          


Ala Lys Met Cys Gly Lys His Trp Cys Gly Thr Ser Pro Leu Met Ser 
        35                  40                  45              


Pro Leu Lys Ala Pro Thr Pro Thr Ala Gly His Arg Ser Cys Ser Ala 
    50                  55                  60                  


Cys Met Asp Gln Met Cys Ser Gly Thr Met Trp Phe Glu Ala Met Gly 
65                  70                  75                  80  


Pro Cys Thr Cys Pro Ser His Leu Ala Gly Thr Lys Gly Pro Ser Pro 
                85                  90                  95      


Cys Leu Ser Gln Asn Leu Arg Leu Asn Cys Arg Ser Leu Gln Ala Gly 
            100                 105                 110         


Ser Trp Gly Gly Gly Pro Ser Thr Gln Thr Pro Arg Trp Trp Leu Arg 
        115                 120                 125             


Val Lys Ala Gly Lys 
    130             


<210>  1394
<211>  147
<212>  PRT
<213>  Homo Sapiens

<400>  1394

Met Met Thr Ser Thr Ala Ser Thr Ala Leu Cys Thr Ala Arg Thr Gly 
1               5                   10                  15      


Pro Pro Gln Arg Val Trp Arg Arg Gly Ser His Arg Ser His Pro Arg 
            20                  25                  30          


Ala Lys Met Cys Gly Lys His Trp Cys Gly Thr Ser Pro Leu Met Ser 
        35                  40                  45              


Pro Leu Lys Ala Pro Thr Pro Thr Ala Gly His Arg Ser Cys Ser Ala 
    50                  55                  60                  


Cys Met Asp Gln Met Cys Ser Gly Thr Met Trp Phe Glu Ala Met Gly 
65                  70                  75                  80  


Pro Cys Thr Cys Pro Ser His Leu Ala Gly Thr Lys Gly Pro Ser Pro 
                85                  90                  95      


Cys Leu Ser Gln Asn Leu Arg Leu Asn Cys Arg Ser Leu Gln Ala Gly 
            100                 105                 110         


Ser Trp Gly Gly Gly Pro Ser Thr Gln Thr Pro Arg Trp Trp Leu Arg 
        115                 120                 125             


Val Lys Ala Gly Lys Pro Pro Ser Gly Leu Ser Val Lys Asp Ser Ser 
    130                 135                 140                 


Val Ser Arg 
145         


<210>  1395
<211>  153
<212>  PRT
<213>  Homo Sapiens

<400>  1395

Met Met Thr Ser Thr Ala Ser Thr Ala Leu Cys Thr Ala Arg Thr Gly 
1               5                   10                  15      


Pro Pro Gln Arg Val Trp Arg Arg Gly Ser His Arg Ser His Pro Arg 
            20                  25                  30          


Ala Lys Met Cys Gly Lys His Trp Cys Gly Thr Ser Pro Leu Met Ser 
        35                  40                  45              


Pro Leu Lys Ala Pro Thr Pro Thr Ala Gly His Arg Ser Cys Ser Ala 
    50                  55                  60                  


Cys Met Asp Gln Met Cys Ser Gly Thr Met Trp Phe Glu Ala Met Gly 
65                  70                  75                  80  


Pro Cys Thr Cys Pro Ser His Leu Ala Gly Thr Lys Gly Pro Ser Pro 
                85                  90                  95      


Cys Leu Ser Gln Asn Leu Arg Leu Asn Cys Arg Ser Leu Gln Ala Gly 
            100                 105                 110         


Ser Trp Gly Gly Gly Pro Ser Thr Gln Thr Pro Arg Trp Trp Leu Arg 
        115                 120                 125             


Val Lys Ala Gly Lys Val Lys Leu Pro Pro Leu Ser Tyr Pro His Pro 
    130                 135                 140                 


Pro Tyr Arg Leu Gln Pro Gly Ser Gly 
145                 150             


<210>  1396
<211>  213
<212>  PRT
<213>  Homo Sapiens

<400>  1396

Met Met Thr Ser Thr Ala Ser Thr Ala Leu Cys Thr Ala Arg Thr Gly 
1               5                   10                  15      


Pro Pro Gln Arg Val Trp Arg Arg Gly Ser His Arg Ser His Pro Arg 
            20                  25                  30          


Ala Lys Met Cys Gly Lys His Trp Cys Gly Thr Ser Pro Leu Met Ser 
        35                  40                  45              


Pro Leu Lys Ala Pro Thr Pro Thr Ala Gly His Arg Ser Cys Ser Ala 
    50                  55                  60                  


Cys Met Asp Gln Met Cys Ser Gly Thr Met Trp Phe Glu Ala Met Gly 
65                  70                  75                  80  


Pro Cys Thr Cys Pro Ser His Leu Ala Gly Thr Lys Gly Pro Ser Pro 
                85                  90                  95      


Cys Leu Ser Gln Asn Leu Arg Leu Asn Cys Arg Ser Leu Gln Ala Gly 
            100                 105                 110         


Ser Trp Gly Gly Gly Pro Ser Thr Gln Thr Pro Arg Trp Trp Leu Arg 
        115                 120                 125             


Val Lys Ala Gly Lys Val Lys Leu Pro Pro Leu Ser Tyr Pro His Pro 
    130                 135                 140                 


Pro Tyr Arg Leu Gln Pro Gly Ser Gly Trp Ala Gln Gly Trp Gly Glu 
145                 150                 155                 160 


Cys Arg Gly Pro Ala Arg His Ile Gly Ala Ser Pro Gln Met Phe Pro 
                165                 170                 175     


Asp Glu Gly Leu Val Gly Ala Gln Arg Val Cys His Val Cys Leu Ser 
            180                 185                 190         


Arg Gln Pro Leu Tyr Leu Pro Val Arg Gly Leu Gly Gln Ala Leu Leu 
        195                 200                 205             


Ser Pro Phe Tyr Arg 
    210             


<210>  1397
<211>  112
<212>  PRT
<213>  Homo Sapiens

<400>  1397

Ser Asn Arg Ala Arg Pro Arg Trp Val Pro Pro Ala Pro Pro Asp Leu 
1               5                   10                  15      


Pro Trp Arg Pro Arg Val Leu Ala Ser Phe Tyr Ser Trp Ser Thr Gly 
            20                  25                  30          


Arg Trp Arg Ala Pro Ser Phe Gln Ser Met Met Thr Ser Thr Ala Ser 
        35                  40                  45              


Thr Ala Leu Cys Thr Ala Arg Thr Gly Pro Pro Gln Arg Val Trp Arg 
    50                  55                  60                  


Arg Gly Ser His Arg Ser His Pro Arg Ala Lys Met Cys Gly Lys His 
65                  70                  75                  80  


Trp Cys Gly Thr Ser Pro Leu Met Ser Pro Leu Lys Ala Pro Thr Pro 
                85                  90                  95      


Thr Ala Ala Val Gln Leu Ala Phe Trp Lys Phe Arg Val His Gln Gly 
            100                 105                 110         


<210>  1398
<211>  396
<212>  PRT
<213>  Homo Sapiens

<400>  1398

Met Gly Ala Leu Ala Arg Ala Leu Leu Leu Pro Leu Leu Ala Gln Trp 
1               5                   10                  15      


Leu Leu Arg Ala Ala Pro Glu Leu Ala Pro Ala Pro Phe Thr Leu Pro 
            20                  25                  30          


Leu Arg Val Ala Ala Ala Thr Asn Arg Val Val Ala Pro Thr Pro Gly 
        35                  40                  45              


Pro Gly Thr Pro Ala Glu Arg His Ala Asp Gly Leu Ala Leu Ala Leu 
    50                  55                  60                  


Glu Pro Ala Leu Ala Ser Pro Ala Gly Ala Ala Asn Phe Leu Ala Met 
65                  70                  75                  80  


Val Asp Asn Leu Gln Gly Asp Ser Gly Arg Gly Tyr Tyr Leu Glu Met 
                85                  90                  95      


Leu Ile Gly Thr Pro Pro Gln Lys Leu Gln Ile Leu Val Asp Thr Gly 
            100                 105                 110         


Ser Ser Asn Phe Ala Val Ala Gly Thr Pro His Ser Tyr Ile Asp Thr 
        115                 120                 125             


Tyr Phe Asp Thr Glu Arg Ser Ser Thr Tyr Arg Ser Lys Gly Phe Asp 
    130                 135                 140                 


Val Thr Val Lys Tyr Thr Gln Gly Ser Trp Thr Gly Phe Val Gly Glu 
145                 150                 155                 160 


Asp Leu Val Thr Ile Pro Lys Gly Phe Asn Thr Ser Phe Leu Val Asn 
                165                 170                 175     


Ile Ala Thr Ile Phe Glu Ser Glu Asn Phe Phe Leu Pro Gly Ile Lys 
            180                 185                 190         


Trp Asn Gly Ile Leu Gly Leu Ala Tyr Ala Thr Leu Ala Lys Pro Ser 
        195                 200                 205             


Ser Ser Leu Glu Thr Phe Phe Asp Ser Leu Val Thr Gln Ala Asn Ile 
    210                 215                 220                 


Pro Asn Val Phe Ser Met Gln Met Cys Gly Ala Gly Leu Pro Val Ala 
225                 230                 235                 240 


Gly Ser Gly Thr Asn Gly Gly Ser Leu Val Leu Gly Gly Ile Glu Pro 
                245                 250                 255     


Ser Leu Tyr Lys Gly Asp Ile Trp Tyr Thr Pro Ile Lys Glu Glu Trp 
            260                 265                 270         


Tyr Tyr Gln Ile Glu Ile Leu Lys Leu Glu Ile Gly Gly Gln Ser Leu 
        275                 280                 285             


Asn Leu Asp Cys Arg Glu Tyr Asn Ala Asp Lys Ala Ile Val Asp Ser 
    290                 295                 300                 


Gly Thr Thr Leu Leu Arg Leu Pro Gln Lys Val Phe Asp Ala Val Val 
305                 310                 315                 320 


Glu Ala Val Ala Arg Ala Ser Leu Ile Pro Glu Phe Ser Asp Gly Phe 
                325                 330                 335     


Trp Thr Gly Ser Gln Leu Ala Cys Trp Thr Asn Ser Glu Thr Pro Trp 
            340                 345                 350         


Ser Tyr Phe Pro Lys Ile Ser Ile Tyr Leu Arg Asp Glu Asn Ser Ser 
        355                 360                 365             


Arg Ser Phe Arg Ile Thr Ile Leu Pro Gln Lys Leu Gln Val Leu Gln 
    370                 375                 380                 


Cys Leu Lys Phe Pro Gly Leu Ser Gln Gln Arg Met 
385                 390                 395     


<210>  1399
<211>  518
<212>  PRT
<213>  Homo Sapiens

<400>  1399

Met Gly Ala Leu Ala Arg Ala Leu Leu Leu Pro Leu Leu Ala Gln Trp 
1               5                   10                  15      


Leu Leu Arg Ala Ala Pro Glu Leu Ala Pro Ala Pro Phe Thr Leu Pro 
            20                  25                  30          


Leu Arg Val Ala Ala Ala Thr Asn Arg Val Val Ala Pro Thr Pro Gly 
        35                  40                  45              


Pro Gly Thr Pro Ala Glu Arg His Ala Asp Gly Leu Ala Leu Ala Leu 
    50                  55                  60                  


Glu Pro Ala Leu Ala Ser Pro Ala Gly Ala Ala Asn Phe Leu Ala Met 
65                  70                  75                  80  


Val Asp Asn Leu Gln Gly Asp Ser Gly Arg Gly Tyr Tyr Leu Glu Met 
                85                  90                  95      


Leu Ile Gly Thr Pro Pro Gln Lys Leu Gln Ile Leu Val Asp Thr Gly 
            100                 105                 110         


Ser Ser Asn Phe Ala Val Ala Gly Thr Pro His Ser Tyr Ile Asp Thr 
        115                 120                 125             


Tyr Phe Asp Thr Glu Arg Ser Ser Thr Tyr Arg Ser Lys Gly Phe Asp 
    130                 135                 140                 


Val Thr Val Lys Tyr Thr Gln Gly Ser Trp Thr Gly Phe Val Gly Glu 
145                 150                 155                 160 


Asp Leu Val Thr Ile Pro Lys Gly Phe Asn Thr Ser Phe Leu Val Asn 
                165                 170                 175     


Ile Ala Thr Ile Phe Glu Ser Glu Asn Phe Phe Leu Pro Gly Ile Lys 
            180                 185                 190         


Trp Asn Gly Ile Leu Gly Leu Ala Tyr Ala Thr Leu Ala Lys Pro Ser 
        195                 200                 205             


Ser Ser Leu Glu Thr Phe Phe Asp Ser Leu Val Thr Gln Ala Asn Ile 
    210                 215                 220                 


Pro Asn Val Phe Ser Met Gln Met Cys Gly Ala Gly Leu Pro Val Ala 
225                 230                 235                 240 


Gly Ser Gly Thr Asn Gly Gly Ser Leu Val Leu Gly Gly Ile Glu Pro 
                245                 250                 255     


Ser Leu Tyr Lys Gly Asp Ile Trp Tyr Thr Pro Ile Lys Glu Glu Trp 
            260                 265                 270         


Tyr Tyr Gln Ile Glu Ile Leu Lys Leu Glu Ile Gly Gly Gln Ser Leu 
        275                 280                 285             


Asn Leu Asp Cys Arg Glu Tyr Asn Ala Asp Lys Ala Ile Val Asp Ser 
    290                 295                 300                 


Gly Thr Thr Leu Leu Arg Leu Pro Gln Lys Val Phe Asp Ala Val Val 
305                 310                 315                 320 


Glu Ala Val Ala Arg Ala Ser Leu Ile Pro Glu Phe Ser Asp Gly Phe 
                325                 330                 335     


Trp Thr Gly Ser Gln Leu Ala Cys Trp Thr Asn Ser Glu Thr Pro Trp 
            340                 345                 350         


Ser Tyr Phe Pro Lys Ile Ser Ile Tyr Leu Arg Asp Glu Asn Ser Ser 
        355                 360                 365             


Arg Ser Phe Arg Ile Thr Ile Leu Pro Gln Leu Tyr Ile Gln Pro Met 
    370                 375                 380                 


Met Gly Ala Gly Leu Asn Tyr Glu Cys Tyr Arg Phe Gly Ile Ser Pro 
385                 390                 395                 400 


Ser Thr Asn Ala Leu Val Ile Gly Ala Thr Val Met Glu Gly Phe Tyr 
                405                 410                 415     


Val Ile Phe Asp Arg Ala Gln Lys Arg Val Gly Phe Ala Ala Ser Pro 
            420                 425                 430         


Cys Ala Glu Ile Ala Gly Ala Ala Val Ser Glu Ile Ser Gly Pro Phe 
        435                 440                 445             


Ser Thr Glu Asp Val Ala Ser Asn Cys Val Pro Ala Gln Ser Leu Ser 
    450                 455                 460                 


Glu Pro Ile Leu Trp Ile Val Ser Tyr Ala Leu Met Ser Val Cys Gly 
465                 470                 475                 480 


Ala Ile Leu Leu Val Leu Ile Val Leu Leu Leu Leu Pro Phe Arg Cys 
                485                 490                 495     


Gln Arg Arg Pro Arg Asp Pro Glu Val Val Asn Asp Glu Ser Ser Leu 
            500                 505                 510         


Val Arg His Arg Trp Lys 
        515             


<210>  1400
<211>  468
<212>  PRT
<213>  Homo Sapiens

<400>  1400

Met Gly Ala Leu Ala Arg Ala Leu Leu Leu Pro Leu Leu Ala Gln Trp 
1               5                   10                  15      


Leu Leu Arg Ala Ala Pro Glu Leu Ala Pro Ala Pro Phe Thr Leu Pro 
            20                  25                  30          


Leu Arg Val Ala Ala Ala Thr Asn Arg Val Val Ala Pro Thr Pro Gly 
        35                  40                  45              


Pro Gly Thr Pro Ala Glu Arg His Ala Asp Gly Leu Ala Leu Ala Leu 
    50                  55                  60                  


Glu Pro Ala Leu Ala Ser Pro Ala Gly Ala Ala Asn Phe Leu Ala Met 
65                  70                  75                  80  


Val Asp Asn Leu Gln Gly Asp Ser Gly Arg Gly Tyr Tyr Leu Glu Met 
                85                  90                  95      


Leu Ile Gly Thr Pro Pro Gln Lys Leu Gln Ile Leu Val Asp Thr Gly 
            100                 105                 110         


Ser Ser Asn Phe Ala Val Ala Gly Thr Pro His Ser Tyr Ile Asp Thr 
        115                 120                 125             


Tyr Phe Asp Thr Glu Arg Ser Ser Thr Tyr Arg Ser Lys Gly Phe Asp 
    130                 135                 140                 


Val Thr Val Lys Tyr Thr Gln Gly Ser Trp Thr Gly Phe Val Gly Glu 
145                 150                 155                 160 


Asp Leu Val Thr Ile Pro Lys Gly Phe Asn Thr Ser Phe Leu Val Asn 
                165                 170                 175     


Ile Ala Thr Ile Phe Glu Ser Glu Asn Phe Phe Leu Pro Gly Ile Lys 
            180                 185                 190         


Trp Asn Gly Ile Leu Gly Leu Ala Tyr Ala Thr Leu Ala Lys Pro Ser 
        195                 200                 205             


Ser Ser Leu Glu Thr Phe Phe Asp Ser Leu Val Thr Gln Ala Asn Ile 
    210                 215                 220                 


Pro Asn Val Phe Ser Met Gln Met Cys Gly Ala Gly Leu Pro Val Ala 
225                 230                 235                 240 


Gly Ser Gly Thr Asn Gly Gly Ser Leu Val Leu Gly Gly Ile Glu Pro 
                245                 250                 255     


Ser Leu Tyr Lys Gly Asp Ile Trp Tyr Thr Pro Ile Lys Glu Glu Trp 
            260                 265                 270         


Tyr Tyr Gln Ile Glu Ile Leu Lys Leu Glu Ile Gly Gly Gln Ser Leu 
        275                 280                 285             


Asn Leu Asp Cys Arg Glu Tyr Asn Ala Asp Lys Ala Ile Val Asp Ser 
    290                 295                 300                 


Gly Thr Thr Leu Leu Arg Leu Pro Gln Lys Val Phe Asp Ala Val Val 
305                 310                 315                 320 


Glu Ala Val Ala Arg Ala Ser Leu Leu Tyr Ile Gln Pro Met Met Gly 
                325                 330                 335     


Ala Gly Leu Asn Tyr Glu Cys Tyr Arg Phe Gly Ile Ser Pro Ser Thr 
            340                 345                 350         


Asn Ala Leu Val Ile Gly Ala Thr Val Met Glu Gly Phe Tyr Val Ile 
        355                 360                 365             


Phe Asp Arg Ala Gln Lys Arg Val Gly Phe Ala Ala Ser Pro Cys Ala 
    370                 375                 380                 


Glu Ile Ala Gly Ala Ala Val Ser Glu Ile Ser Gly Pro Phe Ser Thr 
385                 390                 395                 400 


Glu Asp Val Ala Ser Asn Cys Val Pro Ala Gln Ser Leu Ser Glu Pro 
                405                 410                 415     


Ile Leu Trp Ile Val Ser Tyr Ala Leu Met Ser Val Cys Gly Ala Ile 
            420                 425                 430         


Leu Leu Val Leu Ile Val Leu Leu Leu Leu Pro Phe Arg Cys Gln Arg 
        435                 440                 445             


Arg Pro Arg Asp Pro Glu Val Val Asn Asp Glu Ser Ser Leu Val Arg 
    450                 455                 460                 


His Arg Trp Lys 
465             


<210>  1401
<211>  43
<212>  PRT
<213>  Homo Sapiens

<400>  1401

Met Ala Ala Gly Ala Val Phe Leu Ala Leu Ser Ala Gln Leu Leu Gln 
1               5                   10                  15      


Ala Arg Leu Met Lys Glu Glu Ser Pro Val Val Ser Trp Arg Leu Glu 
            20                  25                  30          


Pro Glu Asp Gly Thr Ala Leu Cys Phe Ile Phe 
        35                  40              


<210>  1402
<211>  628
<212>  PRT
<213>  Homo Sapiens

<400>  1402

Met Glu Pro Pro Asp Ala Pro Ala Gln Ala Arg Gly Ala Pro Arg Leu 
1               5                   10                  15      


Leu Leu Leu Ala Val Leu Leu Ala Ala His Pro Asp Ala Gln Ala Glu 
            20                  25                  30          


Val Arg Leu Ser Val Pro Pro Leu Val Glu Val Met Arg Gly Lys Ser 
        35                  40                  45              


Val Ile Leu Asp Cys Thr Pro Thr Gly Thr His Asp His Tyr Met Leu 
    50                  55                  60                  


Glu Trp Phe Leu Thr Asp Arg Ser Gly Ala Arg Pro Arg Leu Ala Ser 
65                  70                  75                  80  


Ala Glu Met Gln Gly Ser Glu Leu Gln Val Thr Met His Asp Thr Arg 
                85                  90                  95      


Gly Arg Ser Pro Pro Tyr Gln Leu Asp Ser Gln Gly Arg Leu Val Leu 
            100                 105                 110         


Ala Glu Ala Gln Val Gly Asp Glu Arg Asp Tyr Val Cys Val Val Arg 
        115                 120                 125             


Ala Gly Ala Ala Gly Thr Ala Glu Ala Thr Ala Arg Leu Asn Val Phe 
    130                 135                 140                 


Ala Lys Pro Glu Ala Thr Glu Val Ser Pro Asn Lys Gly Thr Leu Ser 
145                 150                 155                 160 


Val Met Glu Asp Ser Ala Gln Glu Ile Ala Thr Cys Asn Ser Arg Asn 
                165                 170                 175     


Gly Asn Pro Ala Pro Lys Ile Thr Trp Tyr Arg Asn Gly Gln Arg Leu 
            180                 185                 190         


Glu Val Pro Val Glu Met Asn Pro Glu Gly Tyr Met Thr Ser Arg Thr 
        195                 200                 205             


Val Arg Glu Ala Ser Gly Leu Leu Ser Leu Thr Ser Thr Leu Tyr Leu 
    210                 215                 220                 


Arg Leu Arg Lys Asp Asp Arg Asp Ala Ser Phe His Cys Ala Ala His 
225                 230                 235                 240 


Tyr Ser Leu Pro Glu Gly Arg His Gly Arg Leu Asp Ser Pro Thr Phe 
                245                 250                 255     


His Leu Thr Leu His Tyr Pro Thr Glu His Val Gln Phe Trp Val Gly 
            260                 265                 270         


Ser Pro Ser Thr Pro Ala Gly Trp Val Arg Glu Gly Asp Thr Val Gln 
        275                 280                 285             


Leu Leu Cys Arg Gly Asp Gly Ser Pro Ser Pro Glu Tyr Thr Leu Phe 
    290                 295                 300                 


Arg Leu Gln Asp Glu Gln Glu Glu Val Leu Asn Val Asn Leu Glu Gly 
305                 310                 315                 320 


Asn Leu Thr Leu Glu Gly Val Thr Arg Gly Gln Ser Gly Thr Tyr Gly 
                325                 330                 335     


Cys Arg Val Glu Asp Tyr Asp Ala Ala Asp Asp Val Gln Leu Ser Lys 
            340                 345                 350         


Thr Leu Glu Leu Arg Val Ala Tyr Leu Asp Pro Leu Glu Leu Ser Glu 
        355                 360                 365             


Gly Lys Val Leu Ser Leu Pro Leu Asn Ser Ser Ala Val Val Asn Cys 
    370                 375                 380                 


Ser Val His Gly Leu Pro Thr Pro Ala Leu Arg Trp Thr Lys Asp Ser 
385                 390                 395                 400 


Thr Pro Leu Gly Asp Gly Pro Met Leu Ser Leu Ser Ser Ile Thr Phe 
                405                 410                 415     


Asp Ser Asn Gly Thr Tyr Val Cys Glu Ala Ser Leu Pro Thr Val Pro 
            420                 425                 430         


Val Leu Ser Arg Thr Gln Asn Phe Thr Leu Leu Val Gln Gly Ser Pro 
        435                 440                 445             


Glu Leu Lys Thr Ala Glu Ile Glu Pro Lys Ala Asp Gly Ser Trp Arg 
    450                 455                 460                 


Glu Gly Asp Glu Val Thr Leu Ile Cys Ser Ala Arg Gly His Pro Asp 
465                 470                 475                 480 


Pro Lys Leu Ser Trp Ser Gln Leu Gly Gly Ser Pro Ala Glu Pro Ile 
                485                 490                 495     


Pro Gly Arg Gln Gly Trp Val Ser Ser Ser Leu Thr Leu Lys Val Thr 
            500                 505                 510         


Ser Ala Leu Ser Arg Asp Gly Ile Ser Cys Glu Ala Ser Asn Pro His 
        515                 520                 525             


Gly Asn Lys Arg His Val Phe His Phe Gly Thr Val Ser Pro Gln Thr 
    530                 535                 540                 


Ser Gln Ala Gly Val Ala Val Met Ala Val Ala Val Ser Val Gly Leu 
545                 550                 555                 560 


Leu Leu Leu Val Val Ala Val Phe Tyr Cys Val Arg Arg Lys Gly Gly 
                565                 570                 575     


Pro Cys Cys Arg Gln Arg Arg Glu Lys Gly Ala Pro Pro Pro Gly Glu 
            580                 585                 590         


Pro Gly Leu Ser His Ser Gly Ser Glu Gln Pro Glu Gln Thr Gly Leu 
        595                 600                 605             


Leu Met Gly Gly Ala Ser Gly Gly Ala Arg Gly Gly Ser Gly Gly Phe 
    610                 615                 620                 


Gly Asp Glu Cys 
625             


<210>  1403
<211>  588
<212>  PRT
<213>  Homo Sapiens

<400>  1403

Met Glu Pro Pro Asp Ala Pro Ala Gln Ala Arg Gly Ala Pro Arg Leu 
1               5                   10                  15      


Leu Leu Leu Ala Val Leu Leu Ala Ala His Pro Asp Ala Gln Ala Glu 
            20                  25                  30          


Val Arg Leu Ser Val Pro Pro Leu Val Glu Val Met Arg Gly Lys Ser 
        35                  40                  45              


Val Ile Leu Asp Cys Thr Pro Thr Gly Thr His Asp His Tyr Met Leu 
    50                  55                  60                  


Glu Trp Phe Leu Thr Asp Arg Ser Gly Ala Arg Pro Arg Leu Ala Ser 
65                  70                  75                  80  


Ala Glu Met Gln Gly Ser Glu Leu Gln Val Thr Met His Asp Thr Arg 
                85                  90                  95      


Gly Arg Ser Pro Pro Tyr Gln Leu Asp Ser Gln Gly Arg Leu Val Leu 
            100                 105                 110         


Ala Glu Ala Gln Val Gly Asp Glu Arg Asp Tyr Val Cys Val Val Arg 
        115                 120                 125             


Ala Gly Ala Ala Gly Thr Ala Glu Ala Thr Ala Arg Leu Asn Val Phe 
    130                 135                 140                 


Ala Lys Pro Glu Ala Thr Glu Val Ser Pro Asn Lys Gly Thr Leu Ser 
145                 150                 155                 160 


Val Met Glu Asp Ser Ala Gln Glu Ile Ala Thr Cys Asn Ser Arg Asn 
                165                 170                 175     


Gly Asn Pro Ala Pro Lys Ile Thr Trp Tyr Arg Asn Gly Gln Arg Leu 
            180                 185                 190         


Glu Val Pro Val Glu Met Asn Pro Glu Gly Tyr Met Thr Ser Arg Thr 
        195                 200                 205             


Val Arg Glu Ala Ser Gly Leu Leu Ser Leu Thr Ser Thr Leu Tyr Leu 
    210                 215                 220                 


Arg Leu Arg Lys Asp Asp Arg Asp Ala Ser Phe His Cys Ala Ala His 
225                 230                 235                 240 


Tyr Ser Leu Pro Glu Gly Arg His Gly Arg Leu Asp Ser Pro Thr Phe 
                245                 250                 255     


His Leu Thr Leu His Tyr Pro Thr Glu His Val Gln Phe Trp Val Gly 
            260                 265                 270         


Ser Pro Ser Thr Pro Ala Gly Trp Val Arg Glu Gly Asp Thr Val Gln 
        275                 280                 285             


Leu Leu Cys Arg Gly Asp Gly Ser Pro Ser Pro Glu Tyr Thr Leu Phe 
    290                 295                 300                 


Arg Leu Gln Asp Glu Gln Glu Glu Val Leu Asn Val Asn Leu Glu Gly 
305                 310                 315                 320 


Asn Leu Thr Leu Glu Gly Val Thr Arg Gly Gln Ser Gly Thr Tyr Gly 
                325                 330                 335     


Cys Arg Val Glu Asp Tyr Asp Ala Ala Asp Asp Val Gln Leu Ser Lys 
            340                 345                 350         


Thr Leu Glu Leu Arg Val Ala Tyr Leu Asp Pro Leu Glu Leu Ser Glu 
        355                 360                 365             


Gly Lys Val Leu Ser Leu Pro Leu Asn Ser Ser Ala Val Val Asn Cys 
    370                 375                 380                 


Ser Val His Gly Leu Pro Thr Pro Ala Leu Arg Trp Thr Lys Asp Ser 
385                 390                 395                 400 


Thr Pro Leu Gly Asp Gly Pro Met Leu Ser Leu Ser Ser Ile Thr Phe 
                405                 410                 415     


Asp Ser Asn Gly Thr Tyr Val Cys Glu Ala Ser Leu Pro Thr Val Pro 
            420                 425                 430         


Val Leu Ser Arg Thr Gln Asn Phe Thr Leu Leu Val Gln Gly Ser Pro 
        435                 440                 445             


Glu Leu Lys Thr Ala Glu Ile Glu Pro Lys Ala Asp Gly Ser Trp Arg 
    450                 455                 460                 


Glu Gly Asp Glu Val Thr Leu Ile Cys Ser Ala Arg Gly His Pro Asp 
465                 470                 475                 480 


Pro Lys Leu Ser Trp Ser Gln Leu Gly Gly Ser Pro Ala Glu Pro Ile 
                485                 490                 495     


Pro Gly Arg Gln Gly Trp Val Ser Ser Ser Leu Thr Leu Lys Val Thr 
            500                 505                 510         


Ser Ala Leu Ser Arg Asp Gly Ile Ser Cys Glu Ala Ser Asn Pro His 
        515                 520                 525             


Gly Asn Lys Arg His Val Phe His Phe Gly Thr Val Ser Pro Gln Thr 
    530                 535                 540                 


Ser Gln Ala Gly Val Ala Val Met Ala Val Ala Val Ser Val Gly Leu 
545                 550                 555                 560 


Leu Leu Leu Val Val Ala Val Phe Tyr Cys Val Arg Arg Lys Gly Gly 
                565                 570                 575     


Pro Cys Cys Arg Gln Arg Arg Glu Lys Gly Ala Pro 
            580                 585             


<210>  1404
<211>  286
<212>  PRT
<213>  Homo Sapiens

<400>  1404

Met Glu Pro Pro Asp Ala Pro Ala Gln Ala Arg Gly Ala Pro Arg Leu 
1               5                   10                  15      


Leu Leu Leu Ala Val Leu Leu Ala Ala His Pro Asp Ala Gln Ala Glu 
            20                  25                  30          


Val Arg Leu Ser Val Pro Pro Leu Val Glu Val Met Arg Gly Lys Ser 
        35                  40                  45              


Val Ile Leu Asp Cys Thr Pro Thr Gly Thr His Asp His Tyr Met Leu 
    50                  55                  60                  


Glu Trp Phe Leu Val Thr Met His Asp Thr Arg Gly Arg Ser Pro Pro 
65                  70                  75                  80  


Tyr Gln Leu Asp Ser Gln Gly Arg Leu Val Leu Ala Glu Ala Gln Val 
                85                  90                  95      


Gly Asp Glu Arg Asp Tyr Val Cys Val Val Arg Ala Gly Ala Ala Gly 
            100                 105                 110         


Thr Ala Glu Ala Thr Ala Arg Leu Asn Val Phe Ala Lys Pro Glu Ala 
        115                 120                 125             


Thr Glu Val Ser Pro Asn Lys Gly Thr Leu Ser Val Met Glu Asp Ser 
    130                 135                 140                 


Ala Gln Glu Ile Ala Thr Cys Asn Ser Arg Asn Gly Asn Pro Ala Pro 
145                 150                 155                 160 


Lys Ile Thr Trp Tyr Arg Asn Gly Gln Arg Leu Glu Val Pro Val Glu 
                165                 170                 175     


Met Asn Pro Glu Gly Tyr Met Thr Ser Arg Thr Val Arg Glu Ala Ser 
            180                 185                 190         


Gly Leu Leu Ser Leu Thr Ser Thr Leu Tyr Leu Arg Leu Arg Lys Asp 
        195                 200                 205             


Asp Arg Asp Ala Ser Phe His Cys Ala Ala His Tyr Ser Leu Pro Glu 
    210                 215                 220                 


Gly Arg His Gly Arg Leu Asp Ser Pro Thr Phe His Leu Thr Leu His 
225                 230                 235                 240 


Tyr Pro Thr Glu His Val Gln Phe Trp Val Gly Ser Pro Ser Thr Pro 
                245                 250                 255     


Ala Gly Trp Val Arg Glu Gly Asp Thr Val Gln Leu Leu Cys Arg Gly 
            260                 265                 270         


Asp Gly Ser Pro Ser Pro Glu Tyr Thr Leu Phe Arg Leu Gln 
        275                 280                 285     


<210>  1405
<211>  61
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1405

Xaa Gly Tyr Met Thr Ser Arg Thr Val Arg Glu Ala Ser Gly Leu Leu 
1               5                   10                  15      


Ser Leu Thr Ser Thr Leu Tyr Leu Arg Leu Arg Lys Asp Asp Arg Asp 
            20                  25                  30          


Ala Ser Phe His Cys Ala Ala His Tyr Ser Leu Pro Glu Gly Arg His 
        35                  40                  45              


Gly Arg Leu Asp Ser Pro Thr Phe His Leu Thr Leu His 
    50                  55                  60      


<210>  1406
<211>  145
<212>  PRT
<213>  Homo Sapiens

<400>  1406

Met Ala Gln Leu Phe Leu Pro Leu Leu Ala Ala Leu Val Leu Ala Gln 
1               5                   10                  15      


Ala Pro Ala Ala Leu Ala Asp Val Leu Glu Gly Asp Ser Ser Glu Asp 
            20                  25                  30          


Arg Ala Phe Arg Val Arg Ile Ala Gly Asp Ala Pro Leu Gln Gly Val 
        35                  40                  45              


Leu Gly Gly Ala Leu Thr Ile Pro Cys His Val His Tyr Leu Arg Pro 
    50                  55                  60                  


Pro Pro Ser Arg Arg Ala Val Leu Gly Ser Pro Arg Val Lys Trp Thr 
65                  70                  75                  80  


Phe Leu Ser Arg Gly Arg Glu Ala Glu Val Leu Val Ala Arg Gly Val 
                85                  90                  95      


Arg Val Lys Val Asn Glu Ala Tyr Arg Phe Arg Val Ala Leu Pro Ala 
            100                 105                 110         


Tyr Pro Ala Ser Leu Thr Asp Val Ser Leu Ala Leu Ser Glu Leu Arg 
        115                 120                 125             


Pro Asn Asp Ser Gly Ile Tyr Arg Cys Glu Val Gln His Gly Ile Asp 
    130                 135                 140                 


Asp 
145 


<210>  1407
<211>  196
<212>  PRT
<213>  Homo Sapiens

<400>  1407

Met Ala Gln Leu Phe Leu Pro Leu Leu Ala Ala Leu Val Leu Ala Gln 
1               5                   10                  15      


Ala Pro Ala Ala Leu Ala Asp Val Leu Glu Gly Asp Ser Ser Glu Asp 
            20                  25                  30          


Arg Ala Phe Arg Val Arg Ile Ala Gly Asp Ala Pro Leu Gln Gly Val 
        35                  40                  45              


Leu Gly Gly Ala Leu Thr Ile Pro Cys His Val His Tyr Leu Arg Pro 
    50                  55                  60                  


Pro Pro Ser Arg Arg Ala Val Leu Gly Ser Pro Arg Val Lys Trp Thr 
65                  70                  75                  80  


Phe Leu Ser Arg Gly Arg Glu Ala Glu Val Leu Val Ala Arg Gly Val 
                85                  90                  95      


Arg Val Lys Val Asn Glu Ala Tyr Arg Phe Arg Val Ala Leu Pro Ala 
            100                 105                 110         


Tyr Pro Ala Ser Leu Thr Asp Val Ser Leu Ala Leu Ser Glu Leu Arg 
        115                 120                 125             


Pro Asn Asp Ser Gly Ile Tyr Arg Cys Glu Val Gln His Gly Ile Asp 
    130                 135                 140                 


Asp Ser Ser Asp Ala Val Glu Val Lys Val Lys Gly Ile Pro Ser Arg 
145                 150                 155                 160 


Pro His Glu Arg Pro Val Thr Glu Thr Trp Met Ala Ser Pro Gly Ser 
                165                 170                 175     


Gly Thr Met Val Trp Trp Thr Arg Met Thr Ser Met Met Cys Thr Val 
            180                 185                 190         


Met Leu Lys Thr 
        195     


<210>  1408
<211>  213
<212>  PRT
<213>  Homo Sapiens

<400>  1408

Met Ala Gln Leu Phe Leu Pro Leu Leu Ala Ala Leu Val Leu Ala Gln 
1               5                   10                  15      


Ala Pro Ala Ala Leu Ala Asp Val Leu Glu Gly Asp Ser Ser Glu Asp 
            20                  25                  30          


Arg Ala Phe Arg Val Arg Ile Ala Gly Asp Ala Pro Leu Gln Gly Val 
        35                  40                  45              


Leu Gly Gly Ala Leu Thr Ile Pro Cys His Val His Tyr Leu Arg Pro 
    50                  55                  60                  


Pro Pro Ser Arg Arg Ala Val Leu Gly Ser Pro Arg Val Lys Trp Thr 
65                  70                  75                  80  


Phe Leu Ser Arg Gly Arg Glu Ala Glu Val Leu Val Ala Arg Gly Val 
                85                  90                  95      


Arg Val Lys Val Asn Glu Ala Tyr Arg Phe Arg Val Ala Leu Pro Ala 
            100                 105                 110         


Tyr Pro Ala Ser Leu Thr Asp Val Ser Leu Ala Leu Ser Glu Leu Arg 
        115                 120                 125             


Pro Asn Asp Ser Gly Ile Tyr Arg Cys Glu Val Gln His Gly Ile Asp 
    130                 135                 140                 


Asp Ser Ser Asp Ala Val Glu Val Lys Val Lys Gly Val Val Phe Leu 
145                 150                 155                 160 


Tyr Arg Glu Gly Ser Ala Arg Tyr Ala Phe Ser Phe Ser Gly Ala Gln 
                165                 170                 175     


Glu Ala Cys Ala Arg Ile Gly Ala His Ile Ala Thr Pro Glu Gln Leu 
            180                 185                 190         


Tyr Ala Ala Tyr Leu Gly Gly Tyr Glu Gln Cys Asp Ala Gly Trp Leu 
        195                 200                 205             


Ser Asp Gln Thr Val 
    210             


<210>  1409
<211>  911
<212>  PRT
<213>  Homo Sapiens

<400>  1409

Met Ala Gln Leu Phe Leu Pro Leu Leu Ala Ala Leu Val Leu Ala Gln 
1               5                   10                  15      


Ala Pro Ala Ala Leu Ala Asp Val Leu Glu Gly Asp Ser Ser Glu Asp 
            20                  25                  30          


Arg Ala Phe Arg Val Arg Ile Ala Gly Asp Ala Pro Leu Gln Gly Val 
        35                  40                  45              


Leu Gly Gly Ala Leu Thr Ile Pro Cys His Val His Tyr Leu Arg Pro 
    50                  55                  60                  


Pro Pro Ser Arg Arg Ala Val Leu Gly Ser Pro Arg Val Lys Trp Thr 
65                  70                  75                  80  


Phe Leu Ser Arg Gly Arg Glu Ala Glu Val Leu Val Ala Arg Gly Val 
                85                  90                  95      


Arg Val Lys Val Asn Glu Ala Tyr Arg Phe Arg Val Ala Leu Pro Ala 
            100                 105                 110         


Tyr Pro Ala Ser Leu Thr Asp Val Ser Leu Ala Leu Ser Glu Leu Arg 
        115                 120                 125             


Pro Asn Asp Ser Gly Ile Tyr Arg Cys Glu Val Gln His Gly Ile Asp 
    130                 135                 140                 


Asp Ser Ser Asp Ala Val Glu Val Lys Val Lys Gly Val Val Phe Leu 
145                 150                 155                 160 


Tyr Arg Glu Gly Ser Ala Arg Tyr Ala Phe Ser Phe Ser Gly Ala Gln 
                165                 170                 175     


Glu Ala Cys Ala Arg Ile Gly Ala His Ile Ala Thr Pro Glu Gln Leu 
            180                 185                 190         


Tyr Ala Ala Tyr Leu Gly Gly Tyr Glu Gln Cys Asp Ala Gly Trp Leu 
        195                 200                 205             


Ser Asp Gln Thr Val Arg Tyr Pro Ile Gln Thr Pro Arg Glu Ala Cys 
    210                 215                 220                 


Tyr Gly Asp Met Asp Gly Phe Pro Gly Val Arg Asn Tyr Gly Val Val 
225                 230                 235                 240 


Asp Pro Asp Asp Leu Tyr Asp Val Tyr Cys Tyr Ala Glu Asp Leu Asn 
                245                 250                 255     


Gly Glu Leu Phe Leu Gly Asp Pro Pro Glu Lys Leu Thr Leu Glu Glu 
            260                 265                 270         


Ala Arg Ala Tyr Cys Gln Glu Arg Gly Ala Glu Ile Ala Thr Thr Gly 
        275                 280                 285             


Gln Leu Tyr Ala Ala Trp Asp Gly Gly Leu Asp His Cys Ser Pro Gly 
    290                 295                 300                 


Trp Leu Ala Asp Gly Ser Val Arg Tyr Pro Ile Val Thr Pro Ser Gln 
305                 310                 315                 320 


Arg Cys Gly Gly Gly Leu Pro Gly Val Lys Thr Leu Phe Leu Phe Pro 
                325                 330                 335     


Asn Gln Thr Gly Phe Pro Asn Lys His Ser Arg Phe Asn Val Tyr Cys 
            340                 345                 350         


Phe Arg Asp Ser Ala Gln Pro Ser Ala Ile Pro Glu Ala Ser Asn Pro 
        355                 360                 365             


Ala Ser Asn Pro Ala Ser Asp Gly Leu Glu Ala Ile Val Thr Val Thr 
    370                 375                 380                 


Glu Thr Leu Glu Glu Leu Gln Leu Pro Gln Glu Ala Thr Glu Ser Glu 
385                 390                 395                 400 


Ser Arg Gly Ala Ile Tyr Ser Ile Pro Ile Met Glu Asp Gly Gly Gly 
                405                 410                 415     


Gly Ser Ser Thr Pro Glu Asp Pro Ala Glu Ala Pro Arg Thr Leu Leu 
            420                 425                 430         


Glu Phe Glu Thr Gln Ser Met Val Pro Pro Thr Gly Phe Ser Glu Glu 
        435                 440                 445             


Glu Gly Lys Ala Leu Glu Glu Glu Glu Lys Tyr Glu Asp Glu Glu Glu 
    450                 455                 460                 


Lys Glu Glu Glu Glu Glu Glu Glu Glu Val Glu Asp Glu Ala Leu Trp 
465                 470                 475                 480 


Ala Trp Pro Ser Glu Leu Ser Ser Pro Gly Pro Glu Ala Ser Leu Pro 
                485                 490                 495     


Thr Glu Pro Ala Ala Gln Glu Glu Ser Leu Ser Gln Ala Pro Ala Arg 
            500                 505                 510         


Ala Val Leu Gln Pro Gly Ala Ser Pro Leu Pro Asp Gly Glu Ser Glu 
        515                 520                 525             


Ala Ser Arg Pro Pro Arg Val His Gly Pro Pro Thr Glu Thr Leu Pro 
    530                 535                 540                 


Thr Pro Arg Glu Arg Asn Leu Ala Ser Pro Ser Pro Ser Thr Leu Val 
545                 550                 555                 560 


Glu Ala Arg Glu Val Gly Glu Ala Thr Gly Gly Pro Glu Leu Ser Gly 
                565                 570                 575     


Val Pro Arg Gly Glu Ser Glu Glu Thr Gly Ser Ser Glu Gly Ala Pro 
            580                 585                 590         


Ser Leu Leu Pro Ala Thr Arg Ala Pro Glu Gly Thr Arg Glu Leu Glu 
        595                 600                 605             


Ala Pro Ser Glu Asp Asn Ser Gly Arg Thr Ala Pro Ala Gly Thr Ser 
    610                 615                 620                 


Val Gln Ala Gln Pro Val Leu Pro Thr Asp Ser Ala Ser Arg Gly Gly 
625                 630                 635                 640 


Val Ala Val Val Pro Ala Ser Gly Asp Cys Val Pro Ser Pro Cys His 
                645                 650                 655     


Asn Gly Gly Thr Cys Leu Glu Glu Glu Glu Gly Val Arg Cys Leu Cys 
            660                 665                 670         


Leu Pro Gly Tyr Gly Gly Asp Leu Cys Asp Val Gly Leu Arg Phe Cys 
        675                 680                 685             


Asn Pro Gly Trp Asp Ala Phe Gln Gly Ala Cys Tyr Lys His Phe Ser 
    690                 695                 700                 


Thr Arg Arg Ser Trp Glu Glu Ala Glu Thr Gln Cys Arg Met Tyr Gly 
705                 710                 715                 720 


Ala His Leu Ala Ser Ile Ser Thr Pro Glu Glu Gln Asp Phe Ile Asn 
                725                 730                 735     


Asn Arg Tyr Arg Glu Tyr Gln Trp Ile Gly Leu Asn Asp Arg Thr Ile 
            740                 745                 750         


Glu Gly Asp Phe Leu Trp Ser Asp Gly Val Pro Leu Leu Tyr Glu Asn 
        755                 760                 765             


Trp Asn Pro Gly Gln Pro Asp Ser Tyr Phe Leu Ser Gly Glu Asn Cys 
    770                 775                 780                 


Val Val Met Val Trp His Asp Gln Gly Gln Trp Ser Asp Val Pro Cys 
785                 790                 795                 800 


Asn Tyr His Leu Ser Tyr Thr Cys Lys Met Gly Leu Val Ser Cys Gly 
                805                 810                 815     


Pro Pro Pro Glu Leu Pro Leu Ala Gln Val Phe Gly Arg Pro Arg Leu 
            820                 825                 830         


Arg Tyr Glu Val Asp Thr Val Leu Arg Tyr Arg Cys Arg Glu Gly Leu 
        835                 840                 845             


Ala Gln Arg Asn Leu Pro Leu Ile Arg Cys Gln Glu Asn Gly Arg Trp 
    850                 855                 860                 


Glu Ala Pro Gln Ile Ser Cys Val Pro Arg Arg Pro Ala Arg Ala Leu 
865                 870                 875                 880 


His Pro Glu Glu Asp Pro Glu Gly Arg Gln Gly Arg Leu Leu Gly Arg 
                885                 890                 895     


Trp Lys Ala Leu Leu Ile Pro Pro Ser Ser Pro Met Pro Gly Pro 
            900                 905                 910     


<210>  1410
<211>  671
<212>  PRT
<213>  Homo Sapiens

<400>  1410

Met Ala Gln Leu Phe Leu Pro Leu Leu Ala Ala Leu Val Leu Ala Gln 
1               5                   10                  15      


Ala Pro Ala Ala Leu Ala Asp Val Leu Glu Gly Asp Ser Ser Glu Asp 
            20                  25                  30          


Arg Ala Phe Arg Val Arg Ile Ala Gly Asp Ala Pro Leu Gln Gly Val 
        35                  40                  45              


Leu Gly Gly Ala Leu Thr Ile Pro Cys His Val His Tyr Leu Arg Pro 
    50                  55                  60                  


Pro Pro Ser Arg Arg Ala Val Leu Gly Ser Pro Arg Val Lys Trp Thr 
65                  70                  75                  80  


Phe Leu Ser Arg Gly Arg Glu Ala Glu Val Leu Val Ala Arg Gly Val 
                85                  90                  95      


Arg Val Lys Val Asn Glu Ala Tyr Arg Phe Arg Val Ala Leu Pro Ala 
            100                 105                 110         


Tyr Pro Ala Ser Leu Thr Asp Val Ser Leu Ala Leu Ser Glu Leu Arg 
        115                 120                 125             


Pro Asn Asp Ser Gly Ile Tyr Arg Cys Glu Val Gln His Gly Ile Asp 
    130                 135                 140                 


Asp Ser Ser Asp Ala Val Glu Val Lys Val Lys Gly Val Val Phe Leu 
145                 150                 155                 160 


Tyr Arg Glu Gly Ser Ala Arg Tyr Ala Phe Ser Phe Ser Gly Ala Gln 
                165                 170                 175     


Glu Ala Cys Ala Arg Ile Gly Ala His Ile Ala Thr Pro Glu Gln Leu 
            180                 185                 190         


Tyr Ala Ala Tyr Leu Gly Gly Tyr Glu Gln Cys Asp Ala Gly Trp Leu 
        195                 200                 205             


Ser Asp Gln Thr Val Arg Tyr Pro Ile Gln Thr Pro Arg Glu Ala Cys 
    210                 215                 220                 


Tyr Gly Asp Met Asp Gly Phe Pro Gly Val Arg Asn Tyr Gly Val Val 
225                 230                 235                 240 


Asp Pro Asp Asp Leu Tyr Asp Val Tyr Cys Tyr Ala Glu Asp Leu Asn 
                245                 250                 255     


Gly Glu Leu Phe Leu Gly Asp Pro Pro Glu Lys Leu Thr Leu Glu Glu 
            260                 265                 270         


Ala Arg Ala Tyr Cys Gln Glu Arg Gly Ala Glu Ile Ala Thr Thr Gly 
        275                 280                 285             


Gln Leu Tyr Ala Ala Trp Asp Gly Gly Leu Asp His Cys Ser Pro Gly 
    290                 295                 300                 


Trp Leu Ala Asp Gly Ser Val Arg Tyr Pro Ile Val Thr Pro Ser Gln 
305                 310                 315                 320 


Arg Cys Gly Gly Gly Leu Pro Gly Val Lys Thr Leu Phe Leu Phe Pro 
                325                 330                 335     


Asn Gln Thr Gly Phe Pro Asn Lys His Ser Arg Phe Asn Val Tyr Cys 
            340                 345                 350         


Phe Arg Asp Ser Ala Gln Pro Ser Ala Ile Pro Glu Ala Ser Asn Pro 
        355                 360                 365             


Ala Ser Asn Pro Ala Ser Asp Gly Leu Glu Ala Ile Val Thr Val Thr 
    370                 375                 380                 


Glu Thr Leu Glu Glu Leu Gln Leu Pro Gln Glu Ala Thr Glu Ser Glu 
385                 390                 395                 400 


Ser Arg Gly Ala Ile Tyr Ser Ile Pro Ile Met Glu Asp Gly Gly Gly 
                405                 410                 415     


Gly Ser Ser Thr Pro Glu Asp Pro Ala Glu Ala Pro Arg Thr Leu Leu 
            420                 425                 430         


Glu Phe Glu Thr Gln Ser Met Val Pro Pro Thr Gly Phe Ser Glu Glu 
        435                 440                 445             


Glu Gly Lys Ala Leu Glu Glu Glu Glu Lys Tyr Glu Asp Glu Glu Glu 
    450                 455                 460                 


Lys Glu Glu Glu Glu Glu Glu Glu Glu Val Glu Asp Glu Ala Leu Trp 
465                 470                 475                 480 


Ala Trp Pro Ser Glu Leu Ser Ser Pro Gly Pro Glu Ala Ser Leu Pro 
                485                 490                 495     


Thr Glu Pro Ala Ala Gln Glu Glu Ser Leu Ser Gln Ala Pro Ala Arg 
            500                 505                 510         


Ala Val Leu Gln Pro Gly Ala Ser Pro Leu Pro Asp Gly Glu Ser Glu 
        515                 520                 525             


Ala Ser Arg Pro Pro Arg Val His Gly Pro Pro Thr Glu Thr Leu Pro 
    530                 535                 540                 


Thr Pro Arg Glu Arg Asn Leu Ala Ser Pro Ser Pro Ser Thr Leu Val 
545                 550                 555                 560 


Glu Ala Arg Glu Val Gly Glu Ala Thr Gly Gly Pro Glu Leu Ser Gly 
                565                 570                 575     


Val Pro Arg Gly Glu Ser Glu Glu Thr Gly Ser Ser Glu Gly Ala Pro 
            580                 585                 590         


Ser Leu Leu Pro Ala Thr Arg Ala Pro Glu Gly Thr Arg Glu Leu Glu 
        595                 600                 605             


Ala Pro Ser Glu Asp Asn Ser Gly Arg Thr Ala Pro Ala Gly Thr Ser 
    610                 615                 620                 


Val Gln Ala Gln Pro Val Leu Pro Thr Asp Ser Ala Ser Arg Gly Gly 
625                 630                 635                 640 


Val Ala Val Val Pro Ala Ser Gly Asn Ser Ala Gln Gly Ser Thr Ala 
                645                 650                 655     


Leu Ser Ile Leu Leu Leu Phe Phe Pro Leu Gln Leu Trp Val Thr 
            660                 665                 670     


<210>  1411
<211>  231
<212>  PRT
<213>  Homo Sapiens

<400>  1411

Met Ala Gln Leu Phe Leu Pro Leu Leu Ala Ala Leu Val Leu Ala Gln 
1               5                   10                  15      


Ala Pro Ala Ala Leu Ala Asp Val Leu Glu Gly Asp Ser Ser Gly Ile 
            20                  25                  30          


Tyr Arg Cys Glu Val Gln His Gly Ile Asp Asp Ser Ser Asp Ala Val 
        35                  40                  45              


Glu Val Lys Val Lys Gly Val Val Phe Leu Tyr Arg Glu Gly Ser Ala 
    50                  55                  60                  


Arg Tyr Ala Phe Ser Phe Ser Gly Ala Gln Glu Ala Cys Ala Arg Ile 
65                  70                  75                  80  


Gly Ala His Ile Ala Thr Pro Glu Gln Leu Tyr Ala Ala Tyr Leu Gly 
                85                  90                  95      


Gly Tyr Glu Gln Cys Asp Ala Gly Trp Leu Ser Asp Gln Thr Val Arg 
            100                 105                 110         


Tyr Pro Ile Gln Thr Pro Arg Glu Ala Cys Tyr Gly Asp Met Asp Gly 
        115                 120                 125             


Phe Pro Gly Val Arg Asn Tyr Gly Val Val Asp Pro Asp Asp Leu Tyr 
    130                 135                 140                 


Asp Val Tyr Cys Tyr Ala Glu Asp Leu Asn Gly Glu Leu Phe Leu Gly 
145                 150                 155                 160 


Asp Pro Pro Glu Lys Leu Thr Leu Glu Glu Ala Arg Ala Tyr Cys Gln 
                165                 170                 175     


Glu Arg Gly Ala Glu Ile Ala Thr Thr Gly Gln Leu Tyr Ala Ala Trp 
            180                 185                 190         


Asp Gly Gly Leu Asp His Cys Ser Pro Gly Trp Leu Ala Asp Gly Ser 
        195                 200                 205             


Val Arg Tyr Pro Ile Val Thr Pro Ser Gln Arg Cys Gly Gly Gly Leu 
    210                 215                 220                 


Pro Gly Val Lys Thr Leu Phe 
225                 230     


<210>  1412
<211>  26
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1412

Xaa His Gly Ile Asp Asp Ser Ser Asp Ala Val Glu Val Lys Val Lys 
1               5                   10                  15      


Gly Gly Gly His Ser Thr His Asn Leu Thr 
            20                  25      


<210>  1413
<211>  294
<212>  PRT
<213>  Homo Sapiens

<400>  1413

Ile Ala Thr Phe Trp Asn Lys Ala Phe Leu Thr Ile Ile Ile Leu Leu 
1               5                   10                  15      


Ile Val Leu Phe Leu Asp Ala Val Arg Glu Val Arg Lys Tyr Ser Ser 
            20                  25                  30          


Val His Thr Ile Glu Lys Ser Ser Thr Ser Arg Pro Asp Ala Tyr Glu 
        35                  40                  45              


His Thr Gln Met Lys Leu Phe Arg Ser Gln Arg Asn Leu Tyr Ile Ser 
    50                  55                  60                  


Gly Phe Ser Leu Phe Phe Trp Leu Val Leu Arg Arg Leu Val Thr Leu 
65                  70                  75                  80  


Ile Thr Gln Leu Ala Lys Glu Leu Ser Asn Lys Gly Val Leu Lys Thr 
                85                  90                  95      


Gln Ala Glu Asn Thr Asn Lys Ala Ala Lys Lys Phe Met Glu Glu Asn 
            100                 105                 110         


Glu Lys Leu Lys Arg Ile Leu Lys Ser His Gly Lys Asp Glu Glu Cys 
        115                 120                 125             


Val Leu Glu Ala Glu Asn Lys Lys Leu Val Glu Asp Gln Glu Lys Leu 
    130                 135                 140                 


Lys Thr Glu Leu Arg Lys Thr Ser Asp Ala Leu Ser Lys Ala Gln Asn 
145                 150                 155                 160 


Asp Val Met Glu Met Lys Met Gln Ser Glu Arg Leu Ser Lys Glu Tyr 
                165                 170                 175     


Asp Gln Leu Leu Lys Glu His Ser Glu Leu Gln Lys Gln Arg Glu Ile 
            180                 185                 190         


Leu Pro His Arg Arg Gly Glu Ser Thr Val Thr Thr Glu Ala Glu Ile 
        195                 200                 205             


Gly Val Met Glu Pro Gln Gln Arg Asn Ala Asp Ser His Gln Lys Leu 
    210                 215                 220                 


Glu Glu Ala Lys Asn Arg Phe Phe Pro Arg Ala Ser Ser Ser Arg Ser 
225                 230                 235                 240 


Met Ala Leu Gln Ile Pro Ile Lys Leu Ile Leu Asp Phe Leu Ala Ser 
                245                 250                 255     


Arg Thr Met Gly Ile Asn Leu Leu Phe Gln Ala Ile Lys Phe Val Ile 
            260                 265                 270         


Ile Cys Tyr Cys Cys His Ser Lys Leu Ile Gln Glu His Ala Gly Gln 
        275                 280                 285             


Ile Cys Asn Gly Leu Asn 
    290                 


<210>  1414
<211>  147
<212>  PRT
<213>  Homo Sapiens

<400>  1414

Met Lys Leu Phe Arg Ser Gln Arg Asn Leu Tyr Ile Ser Gly Phe Ser 
1               5                   10                  15      


Leu Phe Phe Trp Leu Val Leu Arg Arg Leu Val Thr Leu Ile Thr Gln 
            20                  25                  30          


Leu Ala Lys Glu Leu Ser Asn Lys Gly Val Leu Lys Thr Gln Ala Glu 
        35                  40                  45              


Asn Thr Asn Lys Ala Ala Lys Lys Phe Met Glu Glu Asn Glu Lys Leu 
    50                  55                  60                  


Lys Arg Ile Leu Lys Ser His Gly Lys Asp Glu Glu Cys Val Leu Glu 
65                  70                  75                  80  


Ala Glu Asn Lys Lys Leu Val Glu Asp Gln Glu Lys Leu Lys Thr Glu 
                85                  90                  95      


Leu Arg Lys Thr Ser Asp Ala Leu Ser Lys Ala Gln Asn Asp Val Met 
            100                 105                 110         


Glu Met Lys Met Gln Ser Glu Arg Leu Ser Lys Glu Tyr Asp Gln Leu 
        115                 120                 125             


Leu Lys Glu His Ser Glu Leu Gln Asp Arg Leu Glu Arg Gly Asn Lys 
    130                 135                 140                 


Lys Arg Leu 
145         


<210>  1415
<211>  64
<212>  PRT
<213>  Homo Sapiens

<400>  1415

Met Thr Leu Gln Trp Ala Ala Val Ala Thr Phe Leu Tyr Ala Glu Ile 
1               5                   10                  15      


Gly Leu Ile Leu Ile Phe Cys Leu Pro Phe Ile Pro Pro Gln Arg Trp 
            20                  25                  30          


Gln Lys Ile Phe Ser Phe Asn Val Trp Gly Lys Ile Ala Thr Phe Trp 
        35                  40                  45              


Asn Lys Ala Phe Leu Thr Ile Ile Ile Leu Leu Ile Val Leu Phe Leu 
    50                  55                  60                  


<210>  1416
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  1416

Met Thr Leu Gln Trp Ala Ala Val Ala Thr Phe Leu Tyr Ala Glu Ile 
1               5                   10                  15      


Gly Leu Ile Leu Ile Phe Cys Leu Pro Phe Ile Pro Pro Gln Arg Trp 
            20                  25                  30          


Gln Lys Ile Phe Ser Phe Asn Val Trp Gly Lys Ile Ala Thr Phe Trp 
        35                  40                  45              


Asn Lys Ala Phe Leu Thr Ile Ile Ile Leu Leu Ile Val Leu Phe Leu 
    50                  55                  60                  


Asp Ala Val Arg Glu Val Arg Lys Tyr Ser Ser Val His Thr Ile Glu 
65                  70                  75                  80  


Lys Ser Ser Thr Ser Arg Pro Asp Ala Tyr Glu His Thr Gln Met Lys 
                85                  90                  95      


Leu Phe Arg Ser Gln Arg Asn Leu Tyr Ile Ser Gly Phe Ser Leu Phe 
            100                 105                 110         


Phe Trp Leu Val Leu Arg Arg Leu Val Thr Leu Ile Thr Gln Leu Ala 
        115                 120                 125             


Lys Glu Leu Ser Asn 
    130             


<210>  1417
<211>  171
<212>  PRT
<213>  Homo Sapiens

<400>  1417

Met Thr Leu Gln Trp Ala Ala Val Ala Thr Phe Leu Tyr Ala Glu Ile 
1               5                   10                  15      


Gly Leu Ile Leu Ile Phe Cys Leu Pro Phe Ile Pro Pro Gln Arg Trp 
            20                  25                  30          


Gln Lys Ile Phe Ser Phe Asn Val Trp Gly Lys Ile Ala Thr Phe Trp 
        35                  40                  45              


Asn Lys Ala Phe Leu Thr Ile Ile Ile Leu Leu Ile Val Leu Phe Leu 
    50                  55                  60                  


Asp Ala Val Arg Glu Val Arg Lys Tyr Ser Ser Val His Thr Ile Glu 
65                  70                  75                  80  


Lys Ser Ser Thr Ser Arg Pro Asp Ala Tyr Glu His Thr Gln Met Lys 
                85                  90                  95      


Leu Phe Arg Ser Gln Arg Asn Leu Tyr Ile Ser Gly Phe Ser Leu Phe 
            100                 105                 110         


Phe Trp Leu Val Leu Arg Arg Leu Val Thr Leu Ile Thr Gln Leu Ala 
        115                 120                 125             


Lys Glu Leu Ser Asn Lys Gly Val Leu Lys Thr Gln Ala Glu Asn Thr 
    130                 135                 140                 


Asn Lys Ala Ala Lys Lys Phe Met Glu Glu Asn Glu Lys Leu Lys Arg 
145                 150                 155                 160 


Phe Leu Leu Ala Lys Val His Cys Arg Lys Leu 
                165                 170     


<210>  1418
<211>  196
<212>  PRT
<213>  Homo Sapiens

<400>  1418

Met Thr Leu Gln Trp Ala Ala Val Ala Thr Phe Leu Tyr Ala Glu Ile 
1               5                   10                  15      


Gly Leu Ile Leu Ile Phe Cys Leu Pro Phe Ile Pro Pro Gln Arg Trp 
            20                  25                  30          


Gln Lys Ile Phe Ser Phe Asn Val Trp Gly Lys Ile Ala Thr Phe Trp 
        35                  40                  45              


Asn Lys Ala Phe Leu Thr Ile Ile Ile Leu Leu Ile Val Leu Phe Leu 
    50                  55                  60                  


Asp Ala Val Arg Glu Val Arg Lys Tyr Ser Ser Val His Thr Ile Glu 
65                  70                  75                  80  


Lys Ser Ser Thr Ser Arg Pro Asp Ala Tyr Glu His Thr Gln Met Lys 
                85                  90                  95      


Leu Phe Arg Ser Gln Arg Asn Leu Tyr Ile Ser Gly Phe Ser Leu Phe 
            100                 105                 110         


Phe Trp Leu Val Leu Arg Arg Leu Val Thr Leu Ile Thr Gln Leu Ala 
        115                 120                 125             


Lys Glu Leu Ser Asn Lys Gly Val Leu Lys Thr Gln Ala Glu Asn Thr 
    130                 135                 140                 


Asn Lys Ala Ala Lys Lys Phe Met Glu Glu Asn Glu Lys Leu Lys Arg 
145                 150                 155                 160 


Ile Leu Lys Ser His Gly Lys Asp Glu Glu Cys Val Leu Glu Ala Glu 
                165                 170                 175     


Asn Lys Lys Leu Val Glu Asp Gln Glu Lys Leu Lys Thr Glu Leu Arg 
            180                 185                 190         


Lys Thr Ser Asp 
        195     


<210>  1419
<211>  230
<212>  PRT
<213>  Homo Sapiens

<400>  1419

Met Thr Leu Gln Trp Ala Ala Val Ala Thr Phe Leu Tyr Ala Glu Ile 
1               5                   10                  15      


Gly Leu Ile Leu Ile Phe Cys Leu Pro Phe Ile Pro Pro Gln Arg Trp 
            20                  25                  30          


Gln Lys Ile Phe Ser Phe Asn Val Trp Gly Lys Ile Ala Thr Phe Trp 
        35                  40                  45              


Asn Lys Ala Phe Leu Thr Ile Ile Ile Leu Leu Ile Val Leu Phe Leu 
    50                  55                  60                  


Asp Ala Val Arg Glu Val Arg Lys Tyr Ser Ser Val His Thr Ile Glu 
65                  70                  75                  80  


Lys Ser Ser Thr Ser Arg Pro Asp Ala Tyr Glu His Thr Gln Met Lys 
                85                  90                  95      


Leu Phe Arg Ser Gln Arg Asn Leu Tyr Ile Ser Gly Phe Ser Leu Phe 
            100                 105                 110         


Phe Trp Leu Val Leu Arg Arg Leu Val Thr Leu Ile Thr Gln Leu Ala 
        115                 120                 125             


Lys Glu Leu Ser Asn Lys Gly Val Leu Lys Thr Gln Ala Glu Asn Thr 
    130                 135                 140                 


Asn Lys Ala Ala Lys Lys Phe Met Glu Glu Asn Glu Lys Leu Lys Arg 
145                 150                 155                 160 


Ile Leu Lys Ser His Gly Lys Asp Glu Glu Cys Val Leu Glu Ala Glu 
                165                 170                 175     


Asn Lys Lys Leu Val Glu Asp Gln Glu Lys Leu Lys Thr Glu Leu Arg 
            180                 185                 190         


Lys Thr Ser Asp Ala Leu Ser Lys Ala Gln Asn Asp Val Met Glu Met 
        195                 200                 205             


Lys Met Gln Ser Glu Arg Leu Ser Lys Glu Tyr Asp Gln Leu Leu Lys 
    210                 215                 220                 


Glu His Ser Glu Leu Gln 
225                 230 


<210>  1420
<211>  241
<212>  PRT
<213>  Homo Sapiens

<400>  1420

Met Thr Leu Gln Trp Ala Ala Val Ala Thr Phe Leu Tyr Ala Glu Ile 
1               5                   10                  15      


Gly Leu Ile Leu Ile Phe Cys Leu Pro Phe Ile Pro Pro Gln Arg Trp 
            20                  25                  30          


Gln Lys Ile Phe Ser Phe Asn Val Trp Gly Lys Ile Ala Thr Phe Trp 
        35                  40                  45              


Asn Lys Ala Phe Leu Thr Ile Ile Ile Leu Leu Ile Val Leu Phe Leu 
    50                  55                  60                  


Asp Ala Val Arg Glu Val Arg Lys Tyr Ser Ser Val His Thr Ile Glu 
65                  70                  75                  80  


Lys Ser Ser Thr Ser Arg Pro Asp Ala Tyr Glu His Thr Gln Met Lys 
                85                  90                  95      


Leu Phe Arg Ser Gln Arg Asn Leu Tyr Ile Ser Gly Phe Ser Leu Phe 
            100                 105                 110         


Phe Trp Leu Val Leu Arg Arg Leu Val Thr Leu Ile Thr Gln Leu Ala 
        115                 120                 125             


Lys Glu Leu Ser Asn Lys Gly Val Leu Lys Thr Gln Ala Glu Asn Thr 
    130                 135                 140                 


Asn Lys Ala Ala Lys Lys Phe Met Glu Glu Asn Glu Lys Leu Lys Arg 
145                 150                 155                 160 


Ile Leu Lys Ser His Gly Lys Asp Glu Glu Cys Val Leu Glu Ala Glu 
                165                 170                 175     


Asn Lys Lys Leu Val Glu Asp Gln Glu Lys Leu Lys Thr Glu Leu Arg 
            180                 185                 190         


Lys Thr Ser Asp Ala Leu Ser Lys Ala Gln Asn Asp Val Met Glu Met 
        195                 200                 205             


Lys Met Gln Ser Glu Arg Leu Ser Lys Glu Tyr Asp Gln Leu Leu Lys 
    210                 215                 220                 


Glu His Ser Glu Leu Gln Asp Arg Leu Glu Arg Gly Asn Lys Lys Arg 
225                 230                 235                 240 


Leu 
    


<210>  1421
<211>  241
<212>  PRT
<213>  Homo Sapiens

<400>  1421

Met Thr Leu Gln Trp Ala Ala Val Ala Thr Phe Leu Tyr Ala Glu Ile 
1               5                   10                  15      


Gly Leu Ile Leu Ile Phe Cys Leu Pro Phe Ile Pro Pro Gln Arg Trp 
            20                  25                  30          


Gln Lys Ile Phe Ser Phe Asn Val Trp Gly Lys Ile Ala Thr Phe Trp 
        35                  40                  45              


Asn Lys Ala Phe Leu Thr Ile Ile Ile Leu Leu Ile Val Leu Phe Leu 
    50                  55                  60                  


Asp Ala Val Arg Glu Val Arg Lys Tyr Ser Ser Val His Thr Ile Glu 
65                  70                  75                  80  


Lys Ser Ser Thr Ser Arg Pro Asp Ala Tyr Glu His Thr Gln Met Lys 
                85                  90                  95      


Leu Phe Arg Ser Gln Arg Asn Leu Tyr Ile Ser Gly Phe Ser Leu Phe 
            100                 105                 110         


Phe Trp Leu Val Leu Arg Arg Leu Val Thr Leu Ile Thr Gln Leu Ala 
        115                 120                 125             


Lys Glu Leu Ser Asn Lys Gly Val Leu Lys Thr Gln Ala Glu Asn Thr 
    130                 135                 140                 


Asn Lys Ala Ala Lys Lys Phe Met Glu Glu Asn Glu Lys Leu Lys Arg 
145                 150                 155                 160 


Ile Leu Lys Ser His Gly Lys Asp Glu Glu Cys Val Leu Glu Ala Glu 
                165                 170                 175     


Asn Lys Lys Leu Val Glu Asp Gln Glu Lys Leu Lys Thr Glu Leu Arg 
            180                 185                 190         


Lys Thr Ser Asp Ala Leu Ser Lys Ala Gln Asn Asp Val Met Glu Met 
        195                 200                 205             


Lys Met Gln Ser Glu Arg Leu Ser Lys Glu Tyr Asp Gln Leu Leu Lys 
    210                 215                 220                 


Glu His Ser Glu Leu Gln Asp Arg Leu Glu Arg Gly Asn Lys Lys Arg 
225                 230                 235                 240 


Leu 
    


<210>  1422
<211>  348
<212>  PRT
<213>  Homo Sapiens

<400>  1422

Met Thr Leu Gln Trp Ala Ala Val Ala Thr Phe Leu Tyr Ala Glu Ile 
1               5                   10                  15      


Gly Leu Ile Leu Ile Phe Cys Leu Pro Phe Ile Pro Pro Gln Arg Trp 
            20                  25                  30          


Gln Lys Ile Phe Ser Phe Asn Val Trp Gly Lys Ile Ala Thr Phe Trp 
        35                  40                  45              


Asn Lys Ala Phe Leu Thr Ile Ile Ile Leu Leu Ile Val Leu Phe Leu 
    50                  55                  60                  


Asp Ala Val Arg Glu Val Arg Lys Tyr Ser Ser Val His Thr Ile Glu 
65                  70                  75                  80  


Lys Ser Ser Thr Ser Arg Pro Asp Ala Tyr Glu His Thr Gln Met Lys 
                85                  90                  95      


Leu Phe Arg Ser Gln Arg Asn Leu Tyr Ile Ser Gly Phe Ser Leu Phe 
            100                 105                 110         


Phe Trp Leu Val Leu Arg Arg Leu Val Thr Leu Ile Thr Gln Leu Ala 
        115                 120                 125             


Lys Glu Leu Ser Asn Lys Gly Val Leu Lys Thr Gln Ala Glu Asn Thr 
    130                 135                 140                 


Asn Lys Ala Ala Lys Lys Phe Met Glu Glu Asn Glu Lys Leu Lys Arg 
145                 150                 155                 160 


Ile Leu Lys Ser His Gly Lys Asp Glu Glu Cys Val Leu Glu Ala Glu 
                165                 170                 175     


Asn Lys Lys Leu Val Glu Asp Gln Glu Lys Leu Lys Thr Glu Leu Arg 
            180                 185                 190         


Lys Thr Ser Asp Ala Leu Ser Lys Ala Gln Asn Asp Val Met Glu Met 
        195                 200                 205             


Lys Met Gln Ser Glu Arg Leu Ser Lys Glu Tyr Asp Gln Leu Leu Lys 
    210                 215                 220                 


Glu His Ser Glu Leu Gln His Ser Ser Phe Gly Glu Phe Leu Ser Lys 
225                 230                 235                 240 


Arg Ser His Lys Asn Gly Ser Ile Gly Lys Gln Thr Gly Ser Arg Lys 
                245                 250                 255     


Gly Ser Phe Arg Lys Arg Gln Gln Glu Lys Thr Val Asn Phe Ile Lys 
            260                 265                 270         


Asp Thr Cys Asn Ile Leu Cys Gln Asn Asp Asn Phe Val Met Leu Ala 
        275                 280                 285             


Ser Arg Lys Phe Lys Phe Arg Lys Met His Tyr Asp Arg Phe Val Ile 
    290                 295                 300                 


Phe Leu Met Pro His Ile Gly Cys Ile Val Met Ala Leu Ser Lys Tyr 
305                 310                 315                 320 


Leu Met Met Phe Gln Ile Tyr Cys Lys Val Cys Ile Pro Ala Leu Lys 
                325                 330                 335     


Lys Asn Ile Ser Met Leu Asn Thr Ile Phe Thr Tyr 
            340                 345             


<210>  1423
<211>  348
<212>  PRT
<213>  Homo Sapiens

<400>  1423

Met Thr Leu Gln Trp Ala Ala Val Ala Thr Phe Leu Tyr Ala Glu Ile 
1               5                   10                  15      


Gly Leu Ile Leu Ile Phe Cys Leu Pro Phe Ile Pro Pro Gln Arg Trp 
            20                  25                  30          


Gln Lys Ile Phe Ser Phe Asn Val Trp Gly Lys Ile Ala Thr Phe Trp 
        35                  40                  45              


Asn Lys Ala Phe Leu Thr Ile Ile Ile Leu Leu Ile Val Leu Phe Leu 
    50                  55                  60                  


Asp Ala Val Arg Glu Val Arg Lys Tyr Ser Ser Val His Thr Ile Glu 
65                  70                  75                  80  


Lys Ser Ser Thr Ser Arg Pro Asp Ala Tyr Glu His Thr Gln Met Lys 
                85                  90                  95      


Leu Phe Arg Ser Gln Arg Asn Leu Tyr Ile Ser Gly Phe Ser Leu Phe 
            100                 105                 110         


Phe Trp Leu Val Leu Arg Arg Leu Val Thr Leu Ile Thr Gln Leu Ala 
        115                 120                 125             


Lys Glu Leu Ser Asn Lys Gly Val Leu Lys Thr Gln Ala Glu Asn Thr 
    130                 135                 140                 


Asn Lys Ala Ala Lys Lys Phe Met Glu Glu Asn Glu Lys Leu Lys Arg 
145                 150                 155                 160 


Ile Leu Lys Ser His Gly Lys Asp Glu Glu Cys Val Leu Glu Ala Glu 
                165                 170                 175     


Asn Lys Lys Leu Val Glu Asp Gln Glu Lys Leu Lys Thr Glu Leu Arg 
            180                 185                 190         


Lys Thr Ser Asp Ala Leu Ser Lys Ala Gln Asn Asp Val Met Glu Met 
        195                 200                 205             


Lys Met Gln Ser Glu Arg Leu Ser Lys Glu Tyr Asp Gln Leu Leu Lys 
    210                 215                 220                 


Glu His Ser Glu Leu Gln His Ser Ser Phe Gly Glu Phe Leu Ser Lys 
225                 230                 235                 240 


Arg Ser His Lys Asn Gly Ser Ile Gly Lys Gln Thr Gly Ser Arg Lys 
                245                 250                 255     


Gly Ser Phe Arg Lys Arg Gln Gln Glu Lys Thr Val Asn Phe Ile Lys 
            260                 265                 270         


Asp Thr Cys Asn Ile Leu Cys Gln Asn Asp Asn Phe Val Met Leu Ala 
        275                 280                 285             


Ser Arg Lys Phe Lys Phe Arg Lys Met His Tyr Asp Arg Phe Val Ile 
    290                 295                 300                 


Phe Leu Met Pro His Ile Gly Cys Ile Val Met Ala Leu Ser Lys Tyr 
305                 310                 315                 320 


Leu Met Met Phe Gln Ile Tyr Cys Lys Val Cys Ile Pro Ala Leu Lys 
                325                 330                 335     


Lys Asn Ile Ser Met Leu Asn Thr Ile Phe Thr Tyr 
            340                 345             


<210>  1424
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  1424

Met Thr Leu Gln Trp Ala Ala Val Ala Thr Phe Leu Tyr Ala Glu Ile 
1               5                   10                  15      


Gly Leu Ile Leu Ile Phe Cys Leu Pro Phe Ile Pro Pro Gln Arg Trp 
            20                  25                  30          


Gln Lys Ile Phe Ser Phe Asn Val Trp Gly Lys Ile Ala Thr Phe Trp 
        35                  40                  45              


Asn Lys Ala Phe Leu Thr Ile Ile Ile Leu Leu Ile Val Leu Phe Leu 
    50                  55                  60                  


Glu Phe 
65      


<210>  1425
<211>  163
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1425

Xaa Asp Ala Tyr Glu His Thr Gln Met Lys Leu Phe Arg Ser Gln Arg 
1               5                   10                  15      


Asn Leu Tyr Ile Ser Gly Phe Ser Leu Phe Phe Trp Leu Val Leu Arg 
            20                  25                  30          


Arg Leu Val Thr Leu Ile Thr Gln Leu Ala Lys Glu Leu Ser Asn Lys 
        35                  40                  45              


Gly Val Leu Lys Thr Gln Ala Glu Asn Thr Asn Lys Ala Ala Lys Lys 
    50                  55                  60                  


Phe Met Glu Glu Asn Glu Lys Leu Lys Arg Ile Leu Lys Ser His Gly 
65                  70                  75                  80  


Lys Asp Glu Glu Cys Val Leu Glu Ala Glu Asn Lys Lys Leu Val Glu 
                85                  90                  95      


Asp Gln Glu Lys Leu Lys Thr Glu Leu Arg Lys Thr Ser Asp Ala Leu 
            100                 105                 110         


Ser Lys Ala Gln Asn Asp Val Met Glu Met Lys Met Gln Ser Glu Arg 
        115                 120                 125             


Leu Ser Lys Glu Tyr Asp Gln Leu Leu Lys Glu His Ser Glu Leu Gln 
    130                 135                 140                 


Lys Ser His Ser Gln Pro Gly Ala Ala Ala Phe Leu Val Lys Glu Val 
145                 150                 155                 160 


Glu Ser Phe 
            


<210>  1426
<211>  868
<212>  PRT
<213>  Homo Sapiens

<400>  1426

Met Glu Asn Val Leu Ala Lys Ala Leu Tyr Asp Asn Val Ala Glu Ser 
1               5                   10                  15      


Pro Asp Glu Leu Ser Phe Arg Lys Gly Asp Ile Met Thr Val Leu Glu 
            20                  25                  30          


Gln Asp Thr Gln Gly Leu Asp Gly Trp Trp Leu Cys Ser Leu His Gly 
        35                  40                  45              


Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys Ile Leu Val Gly Met 
    50                  55                  60                  


Tyr Asp Lys Lys Pro Ala Gly Pro Gly Pro Gly Pro Pro Ala Thr Pro 
65                  70                  75                  80  


Ala Gln Pro Gln Pro Gly Leu His Ala Pro Ala Pro Pro Ala Ser Gln 
                85                  90                  95      


Tyr Thr Pro Met Leu Pro Asn Thr Tyr Gln Pro Gln Pro Asp Ser Val 
            100                 105                 110         


Tyr Leu Val Pro Thr Pro Ser Lys Ala Gln Gln Gly Leu Tyr Gln Val 
        115                 120                 125             


Pro Gly Pro Ser Pro Gln Phe Gln Ser Pro Pro Ala Lys Gln Thr Ser 
    130                 135                 140                 


Thr Phe Ser Lys Gln Thr Pro His His Pro Phe Pro Ser Pro Ala Thr 
145                 150                 155                 160 


Asp Leu Tyr Gln Val Pro Pro Gly Pro Gly Gly Pro Ala Gln Asp Ile 
                165                 170                 175     


Tyr Gln Val Pro Pro Ser Ala Gly Met Gly His Asp Ile Tyr Gln Val 
            180                 185                 190         


Pro Pro Ser Met Asp Thr Arg Ser Trp Glu Gly Thr Lys Pro Pro Ala 
        195                 200                 205             


Lys Val Val Val Pro Thr Arg Val Gly Gln Gly Tyr Val Tyr Glu Ala 
    210                 215                 220                 


Ala Gln Pro Glu Gln Asp Glu Tyr Asp Ile Pro Arg His Leu Leu Ala 
225                 230                 235                 240 


Pro Gly Pro Gln Asp Ile Tyr Asp Val Pro Pro Val Arg Gly Leu Leu 
                245                 250                 255     


Pro Ser Gln Tyr Gly Gln Glu Val Tyr Asp Thr Pro Pro Met Ala Val 
            260                 265                 270         


Lys Gly Pro Asn Gly Arg Asp Pro Leu Leu Glu Val Tyr Asp Val Pro 
        275                 280                 285             


Pro Ser Val Glu Lys Gly Leu Pro Pro Ser Asn His His Ala Val Tyr 
    290                 295                 300                 


Asp Val Pro Pro Ser Val Ser Lys Asp Val Pro Asp Gly Pro Leu Leu 
305                 310                 315                 320 


Arg Glu Glu Thr Tyr Asp Val Pro Pro Ala Phe Ala Lys Ala Lys Pro 
                325                 330                 335     


Phe Asp Pro Ala Arg Thr Pro Leu Val Leu Ala Ala Pro Pro Pro Asp 
            340                 345                 350         


Ser Pro Pro Ala Glu Asp Val Tyr Asp Val Pro Pro Pro Ala Pro Asp 
        355                 360                 365             


Leu Tyr Asp Val Pro Pro Gly Leu Arg Arg Pro Gly Pro Gly Thr Leu 
    370                 375                 380                 


Tyr Asp Val Pro Arg Glu Arg Val Leu Pro Pro Glu Val Ala Asp Gly 
385                 390                 395                 400 


Gly Val Val Asp Ser Gly Val Tyr Ala Val Pro Pro Pro Ala Glu Arg 
                405                 410                 415     


Glu Ala Pro Ala Glu Gly Lys Arg Leu Ser Ala Ser Ser Thr Gly Ser 
            420                 425                 430         


Thr Arg Ser Ser Gln Ser Ala Ser Ser Leu Glu Val Ala Gly Pro Gly 
        435                 440                 445             


Arg Glu Pro Leu Glu Leu Glu Val Ala Val Glu Ala Leu Ala Arg Leu 
    450                 455                 460                 


Gln Gln Gly Val Ser Ala Thr Val Ala His Leu Leu Asp Leu Ala Gly 
465                 470                 475                 480 


Ser Ala Gly Ala Thr Gly Ser Trp Arg Ser Pro Ser Glu Pro Gln Glu 
                485                 490                 495     


Pro Leu Val Gln Asp Leu Gln Ala Ala Val Ala Ala Val Gln Ser Ala 
            500                 505                 510         


Val His Glu Leu Leu Glu Phe Ala Arg Ser Ala Val Gly Asn Ala Ala 
        515                 520                 525             


His Thr Ser Asp Arg Ala Leu His Ala Lys Leu Ser Arg Gln Leu Gln 
    530                 535                 540                 


Lys Met Glu Asp Val His Gln Thr Leu Val Ala His Gly Gln Ala Leu 
545                 550                 555                 560 


Asp Ala Gly Arg Gly Gly Ser Gly Ala Thr Leu Glu Asp Leu Asp Arg 
                565                 570                 575     


Leu Val Ala Cys Ser Arg Ala Val Pro Glu Asp Ala Lys Gln Leu Ala 
            580                 585                 590         


Ser Phe Leu His Gly Asn Ala Ser Leu Leu Phe Arg Arg Thr Lys Ala 
        595                 600                 605             


Thr Ala Pro Gly Pro Glu Gly Gly Gly Thr Leu His Pro Asn Pro Thr 
    610                 615                 620                 


Asp Lys Thr Ser Ser Ile Gln Ser Arg Pro Leu Pro Ser Pro Pro Lys 
625                 630                 635                 640 


Phe Thr Ser Gln Asp Ser Pro Asp Gly Gln Tyr Glu Asn Ser Glu Gly 
                645                 650                 655     


Gly Trp Met Glu Asp Tyr Asp Tyr Val His Leu Gln Gly Lys Glu Glu 
            660                 665                 670         


Phe Glu Lys Thr Gln Lys Glu Leu Leu Glu Lys Gly Ser Ile Thr Arg 
        675                 680                 685             


Gln Gly Lys Ser Gln Leu Glu Leu Gln Gln Leu Lys Gln Phe Glu Arg 
    690                 695                 700                 


Leu Glu Gln Glu Val Ser Arg Pro Ile Asp His Asp Leu Ala Asn Trp 
705                 710                 715                 720 


Thr Pro Ala Gln Pro Leu Ala Pro Gly Arg Thr Gly Gly Leu Gly Pro 
                725                 730                 735     


Ser Asp Arg Gln Leu Leu Leu Phe Tyr Leu Glu Gln Cys Glu Ala Asn 
            740                 745                 750         


Leu Thr Thr Leu Thr Asn Ala Val Asp Ala Phe Phe Thr Ala Val Ala 
        755                 760                 765             


Thr Asn Gln Pro Pro Lys Ile Phe Val Ala His Ser Lys Phe Val Ile 
    770                 775                 780                 


Leu Ser Ala His Lys Leu Val Phe Ile Gly Asp Thr Leu Ser Arg Gln 
785                 790                 795                 800 


Ala Lys Ala Ala Asp Val Arg Ser Gln Val Thr His Tyr Ser Asn Leu 
                805                 810                 815     


Leu Cys Asp Leu Leu Arg Gly Ile Val Ala Thr Thr Lys Ala Ala Ala 
            820                 825                 830         


Leu Gln Tyr Pro Ser Pro Ser Ala Ala Gln Asp Met Val Glu Arg Val 
        835                 840                 845             


Lys Glu Leu Gly His Ser Thr Gln Gln Phe Arg Arg Val Leu Gly Gln 
    850                 855                 860                 


Leu Ala Ala Ala 
865             


<210>  1427
<211>  888
<212>  PRT
<213>  Homo Sapiens

<400>  1427

Met His Cys Pro Gly Glu Ala Pro Leu Ala Ala Pro Arg Pro Thr Pro 
1               5                   10                  15      


Lys Asp Pro Cys Leu Arg Asn Val Leu Ala Lys Ala Leu Tyr Asp Asn 
            20                  25                  30          


Val Ala Glu Ser Pro Asp Glu Leu Ser Phe Arg Lys Gly Asp Ile Met 
        35                  40                  45              


Thr Val Leu Glu Gln Asp Thr Gln Gly Leu Asp Gly Trp Trp Leu Cys 
    50                  55                  60                  


Ser Leu His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys Ile 
65                  70                  75                  80  


Leu Val Gly Met Tyr Asp Lys Lys Pro Ala Gly Pro Gly Pro Gly Pro 
                85                  90                  95      


Pro Ala Thr Pro Ala Gln Pro Gln Pro Gly Leu His Ala Pro Ala Pro 
            100                 105                 110         


Pro Ala Ser Gln Tyr Thr Pro Met Leu Pro Asn Thr Tyr Gln Pro Gln 
        115                 120                 125             


Pro Asp Ser Val Tyr Leu Val Pro Thr Pro Ser Lys Ala Gln Gln Gly 
    130                 135                 140                 


Leu Tyr Gln Val Pro Gly Pro Ser Pro Gln Phe Gln Ser Pro Pro Ala 
145                 150                 155                 160 


Lys Gln Thr Ser Thr Phe Ser Lys Gln Thr Pro His His Pro Phe Pro 
                165                 170                 175     


Ser Pro Ala Thr Asp Leu Tyr Gln Val Pro Pro Gly Pro Gly Gly Pro 
            180                 185                 190         


Ala Gln Asp Ile Tyr Gln Val Pro Pro Ser Ala Gly Met Gly His Asp 
        195                 200                 205             


Ile Tyr Gln Val Pro Pro Ser Met Asp Thr Arg Ser Trp Glu Gly Thr 
    210                 215                 220                 


Lys Pro Pro Ala Lys Val Val Val Pro Thr Arg Val Gly Gln Gly Tyr 
225                 230                 235                 240 


Val Tyr Glu Ala Ala Gln Pro Glu Gln Asp Glu Tyr Asp Ile Pro Arg 
                245                 250                 255     


His Leu Leu Ala Pro Gly Pro Gln Asp Ile Tyr Asp Val Pro Pro Val 
            260                 265                 270         


Arg Gly Leu Leu Pro Ser Gln Tyr Gly Gln Glu Val Tyr Asp Thr Pro 
        275                 280                 285             


Pro Met Ala Val Lys Gly Pro Asn Gly Arg Asp Pro Leu Leu Glu Val 
    290                 295                 300                 


Tyr Asp Val Pro Pro Ser Val Glu Lys Gly Leu Pro Pro Ser Asn His 
305                 310                 315                 320 


His Ala Val Tyr Asp Val Pro Pro Ser Val Ser Lys Asp Val Pro Asp 
                325                 330                 335     


Gly Pro Leu Leu Arg Glu Glu Thr Tyr Asp Val Pro Pro Ala Phe Ala 
            340                 345                 350         


Lys Ala Lys Pro Phe Asp Pro Ala Arg Thr Pro Leu Val Leu Ala Ala 
        355                 360                 365             


Pro Pro Pro Asp Ser Pro Pro Ala Glu Asp Val Tyr Asp Val Pro Pro 
    370                 375                 380                 


Pro Ala Pro Asp Leu Tyr Asp Val Pro Pro Gly Leu Arg Arg Pro Gly 
385                 390                 395                 400 


Pro Gly Thr Leu Tyr Asp Val Pro Arg Glu Arg Val Leu Pro Pro Glu 
                405                 410                 415     


Val Ala Asp Gly Gly Val Val Asp Ser Gly Val Tyr Ala Val Pro Pro 
            420                 425                 430         


Pro Ala Glu Arg Glu Ala Pro Ala Glu Gly Lys Arg Leu Ser Ala Ser 
        435                 440                 445             


Ser Thr Gly Ser Thr Arg Ser Ser Gln Ser Ala Ser Ser Leu Glu Val 
    450                 455                 460                 


Ala Gly Pro Gly Arg Glu Pro Leu Glu Leu Glu Val Ala Val Glu Ala 
465                 470                 475                 480 


Leu Ala Arg Leu Gln Gln Gly Val Ser Ala Thr Val Ala His Leu Leu 
                485                 490                 495     


Asp Leu Ala Gly Ser Ala Gly Ala Thr Gly Ser Trp Arg Ser Pro Ser 
            500                 505                 510         


Glu Pro Gln Glu Pro Leu Val Gln Asp Leu Gln Ala Ala Val Ala Ala 
        515                 520                 525             


Val Gln Ser Ala Val His Glu Leu Leu Glu Phe Ala Arg Ser Ala Val 
    530                 535                 540                 


Gly Asn Ala Ala His Thr Ser Asp Arg Ala Leu His Ala Lys Leu Ser 
545                 550                 555                 560 


Arg Gln Leu Gln Lys Met Glu Asp Val His Gln Thr Leu Val Ala His 
                565                 570                 575     


Gly Gln Ala Leu Asp Ala Gly Arg Gly Gly Ser Gly Ala Thr Leu Glu 
            580                 585                 590         


Asp Leu Asp Arg Leu Val Ala Cys Ser Arg Ala Val Pro Glu Asp Ala 
        595                 600                 605             


Lys Gln Leu Ala Ser Phe Leu His Gly Asn Ala Ser Leu Leu Phe Arg 
    610                 615                 620                 


Arg Thr Lys Ala Thr Ala Pro Gly Pro Glu Gly Gly Gly Thr Leu His 
625                 630                 635                 640 


Pro Asn Pro Thr Asp Lys Thr Ser Ser Ile Gln Ser Arg Pro Leu Pro 
                645                 650                 655     


Ser Pro Pro Lys Phe Thr Ser Gln Asp Ser Pro Asp Gly Gln Tyr Glu 
            660                 665                 670         


Asn Ser Glu Gly Gly Trp Met Glu Asp Tyr Asp Tyr Val His Leu Gln 
        675                 680                 685             


Gly Lys Glu Glu Phe Glu Lys Thr Gln Lys Glu Leu Leu Glu Lys Gly 
    690                 695                 700                 


Ser Ile Thr Arg Gln Gly Lys Ser Gln Leu Glu Leu Gln Gln Leu Lys 
705                 710                 715                 720 


Gln Phe Glu Arg Leu Glu Gln Glu Val Ser Arg Pro Ile Asp His Asp 
                725                 730                 735     


Leu Ala Asn Trp Thr Pro Ala Gln Pro Leu Ala Pro Gly Arg Thr Gly 
            740                 745                 750         


Gly Leu Gly Pro Ser Asp Arg Gln Leu Leu Leu Phe Tyr Leu Glu Gln 
        755                 760                 765             


Cys Glu Ala Asn Leu Thr Thr Leu Thr Asn Ala Val Asp Ala Phe Phe 
    770                 775                 780                 


Thr Ala Val Ala Thr Asn Gln Pro Pro Lys Ile Phe Val Ala His Ser 
785                 790                 795                 800 


Lys Phe Val Ile Leu Ser Ala His Lys Leu Val Phe Ile Gly Asp Thr 
                805                 810                 815     


Leu Ser Arg Gln Ala Lys Ala Ala Asp Val Arg Ser Gln Val Thr His 
            820                 825                 830         


Tyr Ser Asn Leu Leu Cys Asp Leu Leu Arg Gly Ile Val Ala Thr Thr 
        835                 840                 845             


Lys Ala Ala Ala Leu Gln Tyr Pro Ser Pro Ser Ala Ala Gln Asp Met 
    850                 855                 860                 


Val Glu Arg Val Lys Glu Leu Gly His Ser Thr Gln Gln Phe Arg Arg 
865                 870                 875                 880 


Val Leu Gly Gln Leu Ala Ala Ala 
                885             


<210>  1428
<211>  888
<212>  PRT
<213>  Homo Sapiens

<400>  1428

Met Leu Thr His Arg Pro Gln Glu Ala Glu Gln Arg Gly Arg Thr Pro 
1               5                   10                  15      


Gly Pro Ser Phe Glu Trp Asn Val Leu Ala Lys Ala Leu Tyr Asp Asn 
            20                  25                  30          


Val Ala Glu Ser Pro Asp Glu Leu Ser Phe Arg Lys Gly Asp Ile Met 
        35                  40                  45              


Thr Val Leu Glu Gln Asp Thr Gln Gly Leu Asp Gly Trp Trp Leu Cys 
    50                  55                  60                  


Ser Leu His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys Ile 
65                  70                  75                  80  


Leu Val Gly Met Tyr Asp Lys Lys Pro Ala Gly Pro Gly Pro Gly Pro 
                85                  90                  95      


Pro Ala Thr Pro Ala Gln Pro Gln Pro Gly Leu His Ala Pro Ala Pro 
            100                 105                 110         


Pro Ala Ser Gln Tyr Thr Pro Met Leu Pro Asn Thr Tyr Gln Pro Gln 
        115                 120                 125             


Pro Asp Ser Val Tyr Leu Val Pro Thr Pro Ser Lys Ala Gln Gln Gly 
    130                 135                 140                 


Leu Tyr Gln Val Pro Gly Pro Ser Pro Gln Phe Gln Ser Pro Pro Ala 
145                 150                 155                 160 


Lys Gln Thr Ser Thr Phe Ser Lys Gln Thr Pro His His Pro Phe Pro 
                165                 170                 175     


Ser Pro Ala Thr Asp Leu Tyr Gln Val Pro Pro Gly Pro Gly Gly Pro 
            180                 185                 190         


Ala Gln Asp Ile Tyr Gln Val Pro Pro Ser Ala Gly Met Gly His Asp 
        195                 200                 205             


Ile Tyr Gln Val Pro Pro Ser Met Asp Thr Arg Ser Trp Glu Gly Thr 
    210                 215                 220                 


Lys Pro Pro Ala Lys Val Val Val Pro Thr Arg Val Gly Gln Gly Tyr 
225                 230                 235                 240 


Val Tyr Glu Ala Ala Gln Pro Glu Gln Asp Glu Tyr Asp Ile Pro Arg 
                245                 250                 255     


His Leu Leu Ala Pro Gly Pro Gln Asp Ile Tyr Asp Val Pro Pro Val 
            260                 265                 270         


Arg Gly Leu Leu Pro Ser Gln Tyr Gly Gln Glu Val Tyr Asp Thr Pro 
        275                 280                 285             


Pro Met Ala Val Lys Gly Pro Asn Gly Arg Asp Pro Leu Leu Glu Val 
    290                 295                 300                 


Tyr Asp Val Pro Pro Ser Val Glu Lys Gly Leu Pro Pro Ser Asn His 
305                 310                 315                 320 


His Ala Val Tyr Asp Val Pro Pro Ser Val Ser Lys Asp Val Pro Asp 
                325                 330                 335     


Gly Pro Leu Leu Arg Glu Glu Thr Tyr Asp Val Pro Pro Ala Phe Ala 
            340                 345                 350         


Lys Ala Lys Pro Phe Asp Pro Ala Arg Thr Pro Leu Val Leu Ala Ala 
        355                 360                 365             


Pro Pro Pro Asp Ser Pro Pro Ala Glu Asp Val Tyr Asp Val Pro Pro 
    370                 375                 380                 


Pro Ala Pro Asp Leu Tyr Asp Val Pro Pro Gly Leu Arg Arg Pro Gly 
385                 390                 395                 400 


Pro Gly Thr Leu Tyr Asp Val Pro Arg Glu Arg Val Leu Pro Pro Glu 
                405                 410                 415     


Val Ala Asp Gly Gly Val Val Asp Ser Gly Val Tyr Ala Val Pro Pro 
            420                 425                 430         


Pro Ala Glu Arg Glu Ala Pro Ala Glu Gly Lys Arg Leu Ser Ala Ser 
        435                 440                 445             


Ser Thr Gly Ser Thr Arg Ser Ser Gln Ser Ala Ser Ser Leu Glu Val 
    450                 455                 460                 


Ala Gly Pro Gly Arg Glu Pro Leu Glu Leu Glu Val Ala Val Glu Ala 
465                 470                 475                 480 


Leu Ala Arg Leu Gln Gln Gly Val Ser Ala Thr Val Ala His Leu Leu 
                485                 490                 495     


Asp Leu Ala Gly Ser Ala Gly Ala Thr Gly Ser Trp Arg Ser Pro Ser 
            500                 505                 510         


Glu Pro Gln Glu Pro Leu Val Gln Asp Leu Gln Ala Ala Val Ala Ala 
        515                 520                 525             


Val Gln Ser Ala Val His Glu Leu Leu Glu Phe Ala Arg Ser Ala Val 
    530                 535                 540                 


Gly Asn Ala Ala His Thr Ser Asp Arg Ala Leu His Ala Lys Leu Ser 
545                 550                 555                 560 


Arg Gln Leu Gln Lys Met Glu Asp Val His Gln Thr Leu Val Ala His 
                565                 570                 575     


Gly Gln Ala Leu Asp Ala Gly Arg Gly Gly Ser Gly Ala Thr Leu Glu 
            580                 585                 590         


Asp Leu Asp Arg Leu Val Ala Cys Ser Arg Ala Val Pro Glu Asp Ala 
        595                 600                 605             


Lys Gln Leu Ala Ser Phe Leu His Gly Asn Ala Ser Leu Leu Phe Arg 
    610                 615                 620                 


Arg Thr Lys Ala Thr Ala Pro Gly Pro Glu Gly Gly Gly Thr Leu His 
625                 630                 635                 640 


Pro Asn Pro Thr Asp Lys Thr Ser Ser Ile Gln Ser Arg Pro Leu Pro 
                645                 650                 655     


Ser Pro Pro Lys Phe Thr Ser Gln Asp Ser Pro Asp Gly Gln Tyr Glu 
            660                 665                 670         


Asn Ser Glu Gly Gly Trp Met Glu Asp Tyr Asp Tyr Val His Leu Gln 
        675                 680                 685             


Gly Lys Glu Glu Phe Glu Lys Thr Gln Lys Glu Leu Leu Glu Lys Gly 
    690                 695                 700                 


Ser Ile Thr Arg Gln Gly Lys Ser Gln Leu Glu Leu Gln Gln Leu Lys 
705                 710                 715                 720 


Gln Phe Glu Arg Leu Glu Gln Glu Val Ser Arg Pro Ile Asp His Asp 
                725                 730                 735     


Leu Ala Asn Trp Thr Pro Ala Gln Pro Leu Ala Pro Gly Arg Thr Gly 
            740                 745                 750         


Gly Leu Gly Pro Ser Asp Arg Gln Leu Leu Leu Phe Tyr Leu Glu Gln 
        755                 760                 765             


Cys Glu Ala Asn Leu Thr Thr Leu Thr Asn Ala Val Asp Ala Phe Phe 
    770                 775                 780                 


Thr Ala Val Ala Thr Asn Gln Pro Pro Lys Ile Phe Val Ala His Ser 
785                 790                 795                 800 


Lys Phe Val Ile Leu Ser Ala His Lys Leu Val Phe Ile Gly Asp Thr 
                805                 810                 815     


Leu Ser Arg Gln Ala Lys Ala Ala Asp Val Arg Ser Gln Val Thr His 
            820                 825                 830         


Tyr Ser Asn Leu Leu Cys Asp Leu Leu Arg Gly Ile Val Ala Thr Thr 
        835                 840                 845             


Lys Ala Ala Ala Leu Gln Tyr Pro Ser Pro Ser Ala Ala Gln Asp Met 
    850                 855                 860                 


Val Glu Arg Val Lys Glu Leu Gly His Ser Thr Gln Gln Phe Arg Arg 
865                 870                 875                 880 


Val Leu Gly Gln Leu Ala Ala Ala 
                885             


<210>  1429
<211>  870
<212>  PRT
<213>  Homo Sapiens

<400>  1429

Met Asn His Leu Asn Val Leu Ala Lys Ala Leu Tyr Asp Asn Val Ala 
1               5                   10                  15      


Glu Ser Pro Asp Glu Leu Ser Phe Arg Lys Gly Asp Ile Met Thr Val 
            20                  25                  30          


Leu Glu Gln Asp Thr Gln Gly Leu Asp Gly Trp Trp Leu Cys Ser Leu 
        35                  40                  45              


His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys Ile Leu Val 
    50                  55                  60                  


Gly Met Tyr Asp Lys Lys Pro Ala Gly Pro Gly Pro Gly Pro Pro Ala 
65                  70                  75                  80  


Thr Pro Ala Gln Pro Gln Pro Gly Leu His Ala Pro Ala Pro Pro Ala 
                85                  90                  95      


Ser Gln Tyr Thr Pro Met Leu Pro Asn Thr Tyr Gln Pro Gln Pro Asp 
            100                 105                 110         


Ser Val Tyr Leu Val Pro Thr Pro Ser Lys Ala Gln Gln Gly Leu Tyr 
        115                 120                 125             


Gln Val Pro Gly Pro Ser Pro Gln Phe Gln Ser Pro Pro Ala Lys Gln 
    130                 135                 140                 


Thr Ser Thr Phe Ser Lys Gln Thr Pro His His Pro Phe Pro Ser Pro 
145                 150                 155                 160 


Ala Thr Asp Leu Tyr Gln Val Pro Pro Gly Pro Gly Gly Pro Ala Gln 
                165                 170                 175     


Asp Ile Tyr Gln Val Pro Pro Ser Ala Gly Met Gly His Asp Ile Tyr 
            180                 185                 190         


Gln Val Pro Pro Ser Met Asp Thr Arg Ser Trp Glu Gly Thr Lys Pro 
        195                 200                 205             


Pro Ala Lys Val Val Val Pro Thr Arg Val Gly Gln Gly Tyr Val Tyr 
    210                 215                 220                 


Glu Ala Ala Gln Pro Glu Gln Asp Glu Tyr Asp Ile Pro Arg His Leu 
225                 230                 235                 240 


Leu Ala Pro Gly Pro Gln Asp Ile Tyr Asp Val Pro Pro Val Arg Gly 
                245                 250                 255     


Leu Leu Pro Ser Gln Tyr Gly Gln Glu Val Tyr Asp Thr Pro Pro Met 
            260                 265                 270         


Ala Val Lys Gly Pro Asn Gly Arg Asp Pro Leu Leu Glu Val Tyr Asp 
        275                 280                 285             


Val Pro Pro Ser Val Glu Lys Gly Leu Pro Pro Ser Asn His His Ala 
    290                 295                 300                 


Val Tyr Asp Val Pro Pro Ser Val Ser Lys Asp Val Pro Asp Gly Pro 
305                 310                 315                 320 


Leu Leu Arg Glu Glu Thr Tyr Asp Val Pro Pro Ala Phe Ala Lys Ala 
                325                 330                 335     


Lys Pro Phe Asp Pro Ala Arg Thr Pro Leu Val Leu Ala Ala Pro Pro 
            340                 345                 350         


Pro Asp Ser Pro Pro Ala Glu Asp Val Tyr Asp Val Pro Pro Pro Ala 
        355                 360                 365             


Pro Asp Leu Tyr Asp Val Pro Pro Gly Leu Arg Arg Pro Gly Pro Gly 
    370                 375                 380                 


Thr Leu Tyr Asp Val Pro Arg Glu Arg Val Leu Pro Pro Glu Val Ala 
385                 390                 395                 400 


Asp Gly Gly Val Val Asp Ser Gly Val Tyr Ala Val Pro Pro Pro Ala 
                405                 410                 415     


Glu Arg Glu Ala Pro Ala Glu Gly Lys Arg Leu Ser Ala Ser Ser Thr 
            420                 425                 430         


Gly Ser Thr Arg Ser Ser Gln Ser Ala Ser Ser Leu Glu Val Ala Gly 
        435                 440                 445             


Pro Gly Arg Glu Pro Leu Glu Leu Glu Val Ala Val Glu Ala Leu Ala 
    450                 455                 460                 


Arg Leu Gln Gln Gly Val Ser Ala Thr Val Ala His Leu Leu Asp Leu 
465                 470                 475                 480 


Ala Gly Ser Ala Gly Ala Thr Gly Ser Trp Arg Ser Pro Ser Glu Pro 
                485                 490                 495     


Gln Glu Pro Leu Val Gln Asp Leu Gln Ala Ala Val Ala Ala Val Gln 
            500                 505                 510         


Ser Ala Val His Glu Leu Leu Glu Phe Ala Arg Ser Ala Val Gly Asn 
        515                 520                 525             


Ala Ala His Thr Ser Asp Arg Ala Leu His Ala Lys Leu Ser Arg Gln 
    530                 535                 540                 


Leu Gln Lys Met Glu Asp Val His Gln Thr Leu Val Ala His Gly Gln 
545                 550                 555                 560 


Ala Leu Asp Ala Gly Arg Gly Gly Ser Gly Ala Thr Leu Glu Asp Leu 
                565                 570                 575     


Asp Arg Leu Val Ala Cys Ser Arg Ala Val Pro Glu Asp Ala Lys Gln 
            580                 585                 590         


Leu Ala Ser Phe Leu His Gly Asn Ala Ser Leu Leu Phe Arg Arg Thr 
        595                 600                 605             


Lys Ala Thr Ala Pro Gly Pro Glu Gly Gly Gly Thr Leu His Pro Asn 
    610                 615                 620                 


Pro Thr Asp Lys Thr Ser Ser Ile Gln Ser Arg Pro Leu Pro Ser Pro 
625                 630                 635                 640 


Pro Lys Phe Thr Ser Gln Asp Ser Pro Asp Gly Gln Tyr Glu Asn Ser 
                645                 650                 655     


Glu Gly Gly Trp Met Glu Asp Tyr Asp Tyr Val His Leu Gln Gly Lys 
            660                 665                 670         


Glu Glu Phe Glu Lys Thr Gln Lys Glu Leu Leu Glu Lys Gly Ser Ile 
        675                 680                 685             


Thr Arg Gln Gly Lys Ser Gln Leu Glu Leu Gln Gln Leu Lys Gln Phe 
    690                 695                 700                 


Glu Arg Leu Glu Gln Glu Val Ser Arg Pro Ile Asp His Asp Leu Ala 
705                 710                 715                 720 


Asn Trp Thr Pro Ala Gln Pro Leu Ala Pro Gly Arg Thr Gly Gly Leu 
                725                 730                 735     


Gly Pro Ser Asp Arg Gln Leu Leu Leu Phe Tyr Leu Glu Gln Cys Glu 
            740                 745                 750         


Ala Asn Leu Thr Thr Leu Thr Asn Ala Val Asp Ala Phe Phe Thr Ala 
        755                 760                 765             


Val Ala Thr Asn Gln Pro Pro Lys Ile Phe Val Ala His Ser Lys Phe 
    770                 775                 780                 


Val Ile Leu Ser Ala His Lys Leu Val Phe Ile Gly Asp Thr Leu Ser 
785                 790                 795                 800 


Arg Gln Ala Lys Ala Ala Asp Val Arg Ser Gln Val Thr His Tyr Ser 
                805                 810                 815     


Asn Leu Leu Cys Asp Leu Leu Arg Gly Ile Val Ala Thr Thr Lys Ala 
            820                 825                 830         


Ala Ala Leu Gln Tyr Pro Ser Pro Ser Ala Ala Gln Asp Met Val Glu 
        835                 840                 845             


Arg Val Lys Glu Leu Gly His Ser Thr Gln Gln Phe Arg Arg Val Leu 
    850                 855                 860                 


Gly Gln Leu Ala Ala Ala 
865                 870 


<210>  1430
<211>  888
<212>  PRT
<213>  Homo Sapiens

<400>  1430

Met Asn His Leu Asn Val Leu Ala Lys Ala Leu Tyr Asp Asn Val Ala 
1               5                   10                  15      


Glu Ser Pro Asp Glu Leu Ser Phe Arg Lys Gly Asp Ile Met Thr Val 
            20                  25                  30          


Leu Glu Gln Asp Thr Gln Gly Leu Asp Gly Trp Trp Leu Cys Ser Leu 
        35                  40                  45              


His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys Ile Leu Val 
    50                  55                  60                  


Gly Met Tyr Asp Lys Lys Pro Ala Gly Pro Gly Pro Gly Pro Pro Ala 
65                  70                  75                  80  


Thr Pro Ala Gln Pro Gln Pro Gly Leu His Ala Pro Ala Pro Pro Ala 
                85                  90                  95      


Ser Gln Tyr Thr Pro Met Leu Pro Asn Thr Tyr Gln Pro Gln Pro Asp 
            100                 105                 110         


Ser Val Tyr Leu Val Pro Thr Pro Ser Lys Ala Gln Gln Gly Leu Tyr 
        115                 120                 125             


Gln Val Pro Gly Pro Ser Pro Gln Phe Gln Ser Pro Pro Ala Lys Gln 
    130                 135                 140                 


Thr Ser Thr Phe Ser Lys Gln Thr Pro His His Pro Phe Pro Ser Pro 
145                 150                 155                 160 


Ala Thr Asp Leu Tyr Gln Val Pro Pro Gly Pro Gly Gly Pro Ala Gln 
                165                 170                 175     


Asp Ile Tyr Gln Val Pro Pro Ser Ala Gly Met Gly His Asp Ile Tyr 
            180                 185                 190         


Gln Val Pro Pro Ser Met Asp Thr Arg Ser Trp Glu Gly Thr Lys Pro 
        195                 200                 205             


Pro Ala Lys Val Val Val Pro Thr Arg Val Gly Gln Gly Tyr Val Tyr 
    210                 215                 220                 


Glu Ala Ala Gln Pro Glu Gln Asp Glu Tyr Asp Ile Pro Arg His Leu 
225                 230                 235                 240 


Leu Ala Pro Gly Pro Gln Asp Ile Tyr Asp Val Pro Pro Val Arg Gly 
                245                 250                 255     


Leu Leu Pro Ser Gln Tyr Gly Gln Glu Val Tyr Asp Thr Pro Pro Met 
            260                 265                 270         


Ala Val Lys Gly Pro Asn Gly Arg Asp Pro Leu Leu Glu Val Tyr Asp 
        275                 280                 285             


Val Pro Pro Ser Val Glu Lys Gly Leu Pro Pro Ser Asn His His Ala 
    290                 295                 300                 


Val Ser Lys Cys Gln Gly Asn Ala Arg Ala Arg Leu Arg Leu Trp Gly 
305                 310                 315                 320 


Val Trp Val Tyr Asp Val Pro Pro Ser Val Ser Lys Asp Val Pro Asp 
                325                 330                 335     


Gly Pro Leu Leu Arg Glu Glu Thr Tyr Asp Val Pro Pro Ala Phe Ala 
            340                 345                 350         


Lys Ala Lys Pro Phe Asp Pro Ala Arg Thr Pro Leu Val Leu Ala Ala 
        355                 360                 365             


Pro Pro Pro Asp Ser Pro Pro Ala Glu Asp Val Tyr Asp Val Pro Pro 
    370                 375                 380                 


Pro Ala Pro Asp Leu Tyr Asp Val Pro Pro Gly Leu Arg Arg Pro Gly 
385                 390                 395                 400 


Pro Gly Thr Leu Tyr Asp Val Pro Arg Glu Arg Val Leu Pro Pro Glu 
                405                 410                 415     


Val Ala Asp Gly Gly Val Val Asp Ser Gly Val Tyr Ala Val Pro Pro 
            420                 425                 430         


Pro Ala Glu Arg Glu Ala Pro Ala Glu Gly Lys Arg Leu Ser Ala Ser 
        435                 440                 445             


Ser Thr Gly Ser Thr Arg Ser Ser Gln Ser Ala Ser Ser Leu Glu Val 
    450                 455                 460                 


Ala Gly Pro Gly Arg Glu Pro Leu Glu Leu Glu Val Ala Val Glu Ala 
465                 470                 475                 480 


Leu Ala Arg Leu Gln Gln Gly Val Ser Ala Thr Val Ala His Leu Leu 
                485                 490                 495     


Asp Leu Ala Gly Ser Ala Gly Ala Thr Gly Ser Trp Arg Ser Pro Ser 
            500                 505                 510         


Glu Pro Gln Glu Pro Leu Val Gln Asp Leu Gln Ala Ala Val Ala Ala 
        515                 520                 525             


Val Gln Ser Ala Val His Glu Leu Leu Glu Phe Ala Arg Ser Ala Val 
    530                 535                 540                 


Gly Asn Ala Ala His Thr Ser Asp Arg Ala Leu His Ala Lys Leu Ser 
545                 550                 555                 560 


Arg Gln Leu Gln Lys Met Glu Asp Val His Gln Thr Leu Val Ala His 
                565                 570                 575     


Gly Gln Ala Leu Asp Ala Gly Arg Gly Gly Ser Gly Ala Thr Leu Glu 
            580                 585                 590         


Asp Leu Asp Arg Leu Val Ala Cys Ser Arg Ala Val Pro Glu Asp Ala 
        595                 600                 605             


Lys Gln Leu Ala Ser Phe Leu His Gly Asn Ala Ser Leu Leu Phe Arg 
    610                 615                 620                 


Arg Thr Lys Ala Thr Ala Pro Gly Pro Glu Gly Gly Gly Thr Leu His 
625                 630                 635                 640 


Pro Asn Pro Thr Asp Lys Thr Ser Ser Ile Gln Ser Arg Pro Leu Pro 
                645                 650                 655     


Ser Pro Pro Lys Phe Thr Ser Gln Asp Ser Pro Asp Gly Gln Tyr Glu 
            660                 665                 670         


Asn Ser Glu Gly Gly Trp Met Glu Asp Tyr Asp Tyr Val His Leu Gln 
        675                 680                 685             


Gly Lys Glu Glu Phe Glu Lys Thr Gln Lys Glu Leu Leu Glu Lys Gly 
    690                 695                 700                 


Ser Ile Thr Arg Gln Gly Lys Ser Gln Leu Glu Leu Gln Gln Leu Lys 
705                 710                 715                 720 


Gln Phe Glu Arg Leu Glu Gln Glu Val Ser Arg Pro Ile Asp His Asp 
                725                 730                 735     


Leu Ala Asn Trp Thr Pro Ala Gln Pro Leu Ala Pro Gly Arg Thr Gly 
            740                 745                 750         


Gly Leu Gly Pro Ser Asp Arg Gln Leu Leu Leu Phe Tyr Leu Glu Gln 
        755                 760                 765             


Cys Glu Ala Asn Leu Thr Thr Leu Thr Asn Ala Val Asp Ala Phe Phe 
    770                 775                 780                 


Thr Ala Val Ala Thr Asn Gln Pro Pro Lys Ile Phe Val Ala His Ser 
785                 790                 795                 800 


Lys Phe Val Ile Leu Ser Ala His Lys Leu Val Phe Ile Gly Asp Thr 
                805                 810                 815     


Leu Ser Arg Gln Ala Lys Ala Ala Asp Val Arg Ser Gln Val Thr His 
            820                 825                 830         


Tyr Ser Asn Leu Leu Cys Asp Leu Leu Arg Gly Ile Val Ala Thr Thr 
        835                 840                 845             


Lys Ala Ala Ala Leu Gln Tyr Pro Ser Pro Ser Ala Ala Gln Asp Met 
    850                 855                 860                 


Val Glu Arg Val Lys Glu Leu Gly His Ser Thr Gln Gln Phe Arg Arg 
865                 870                 875                 880 


Val Leu Gly Gln Leu Ala Ala Ala 
                885             


<210>  1431
<211>  916
<212>  PRT
<213>  Homo Sapiens

<400>  1431

Met Pro Ala Lys Pro Phe Leu Ser Ser Val Leu Leu Ser Trp Lys Val 
1               5                   10                  15      


Leu Asp Phe Ser Gly Pro Gly Pro Gln Gly Thr Gly Gln Pro Cys Ser 
            20                  25                  30          


Cys Gly His Trp Ala Glu Gly Gln Gly Gly Pro Pro Glu Pro Ala Gly 
        35                  40                  45              


Gly Pro Asn Val Leu Ala Lys Ala Leu Tyr Asp Asn Val Ala Glu Ser 
    50                  55                  60                  


Pro Asp Glu Leu Ser Phe Arg Lys Gly Asp Ile Met Thr Val Leu Glu 
65                  70                  75                  80  


Gln Asp Thr Gln Gly Leu Asp Gly Trp Trp Leu Cys Ser Leu His Gly 
                85                  90                  95      


Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys Ile Leu Val Gly Met 
            100                 105                 110         


Tyr Asp Lys Lys Pro Ala Gly Pro Gly Pro Gly Pro Pro Ala Thr Pro 
        115                 120                 125             


Ala Gln Pro Gln Pro Gly Leu His Ala Pro Ala Pro Pro Ala Ser Gln 
    130                 135                 140                 


Tyr Thr Pro Met Leu Pro Asn Thr Tyr Gln Pro Gln Pro Asp Ser Val 
145                 150                 155                 160 


Tyr Leu Val Pro Thr Pro Ser Lys Ala Gln Gln Gly Leu Tyr Gln Val 
                165                 170                 175     


Pro Gly Pro Ser Pro Gln Phe Gln Ser Pro Pro Ala Lys Gln Thr Ser 
            180                 185                 190         


Thr Phe Ser Lys Gln Thr Pro His His Pro Phe Pro Ser Pro Ala Thr 
        195                 200                 205             


Asp Leu Tyr Gln Val Pro Pro Gly Pro Gly Gly Pro Ala Gln Asp Ile 
    210                 215                 220                 


Tyr Gln Val Pro Pro Ser Ala Gly Met Gly His Asp Ile Tyr Gln Val 
225                 230                 235                 240 


Pro Pro Ser Met Asp Thr Arg Ser Trp Glu Gly Thr Lys Pro Pro Ala 
                245                 250                 255     


Lys Val Val Val Pro Thr Arg Val Gly Gln Gly Tyr Val Tyr Glu Ala 
            260                 265                 270         


Ala Gln Pro Glu Gln Asp Glu Tyr Asp Ile Pro Arg His Leu Leu Ala 
        275                 280                 285             


Pro Gly Pro Gln Asp Ile Tyr Asp Val Pro Pro Val Arg Gly Leu Leu 
    290                 295                 300                 


Pro Ser Gln Tyr Gly Gln Glu Val Tyr Asp Thr Pro Pro Met Ala Val 
305                 310                 315                 320 


Lys Gly Pro Asn Gly Arg Asp Pro Leu Leu Glu Val Tyr Asp Val Pro 
                325                 330                 335     


Pro Ser Val Glu Lys Gly Leu Pro Pro Ser Asn His His Ala Val Tyr 
            340                 345                 350         


Asp Val Pro Pro Ser Val Ser Lys Asp Val Pro Asp Gly Pro Leu Leu 
        355                 360                 365             


Arg Glu Glu Thr Tyr Asp Val Pro Pro Ala Phe Ala Lys Ala Lys Pro 
    370                 375                 380                 


Phe Asp Pro Ala Arg Thr Pro Leu Val Leu Ala Ala Pro Pro Pro Asp 
385                 390                 395                 400 


Ser Pro Pro Ala Glu Asp Val Tyr Asp Val Pro Pro Pro Ala Pro Asp 
                405                 410                 415     


Leu Tyr Asp Val Pro Pro Gly Leu Arg Arg Pro Gly Pro Gly Thr Leu 
            420                 425                 430         


Tyr Asp Val Pro Arg Glu Arg Val Leu Pro Pro Glu Val Ala Asp Gly 
        435                 440                 445             


Gly Val Val Asp Ser Gly Val Tyr Ala Val Pro Pro Pro Ala Glu Arg 
    450                 455                 460                 


Glu Ala Pro Ala Glu Gly Lys Arg Leu Ser Ala Ser Ser Thr Gly Ser 
465                 470                 475                 480 


Thr Arg Ser Ser Gln Ser Ala Ser Ser Leu Glu Val Ala Gly Pro Gly 
                485                 490                 495     


Arg Glu Pro Leu Glu Leu Glu Val Ala Val Glu Ala Leu Ala Arg Leu 
            500                 505                 510         


Gln Gln Gly Val Ser Ala Thr Val Ala His Leu Leu Asp Leu Ala Gly 
        515                 520                 525             


Ser Ala Gly Ala Thr Gly Ser Trp Arg Ser Pro Ser Glu Pro Gln Glu 
    530                 535                 540                 


Pro Leu Val Gln Asp Leu Gln Ala Ala Val Ala Ala Val Gln Ser Ala 
545                 550                 555                 560 


Val His Glu Leu Leu Glu Phe Ala Arg Ser Ala Val Gly Asn Ala Ala 
                565                 570                 575     


His Thr Ser Asp Arg Ala Leu His Ala Lys Leu Ser Arg Gln Leu Gln 
            580                 585                 590         


Lys Met Glu Asp Val His Gln Thr Leu Val Ala His Gly Gln Ala Leu 
        595                 600                 605             


Asp Ala Gly Arg Gly Gly Ser Gly Ala Thr Leu Glu Asp Leu Asp Arg 
    610                 615                 620                 


Leu Val Ala Cys Ser Arg Ala Val Pro Glu Asp Ala Lys Gln Leu Ala 
625                 630                 635                 640 


Ser Phe Leu His Gly Asn Ala Ser Leu Leu Phe Arg Arg Thr Lys Ala 
                645                 650                 655     


Thr Ala Pro Gly Pro Glu Gly Gly Gly Thr Leu His Pro Asn Pro Thr 
            660                 665                 670         


Asp Lys Thr Ser Ser Ile Gln Ser Arg Pro Leu Pro Ser Pro Pro Lys 
        675                 680                 685             


Phe Thr Ser Gln Asp Ser Pro Asp Gly Gln Tyr Glu Asn Ser Glu Gly 
    690                 695                 700                 


Gly Trp Met Glu Asp Tyr Asp Tyr Val His Leu Gln Gly Lys Glu Glu 
705                 710                 715                 720 


Phe Glu Lys Thr Gln Lys Glu Leu Leu Glu Lys Gly Ser Ile Thr Arg 
                725                 730                 735     


Gln Gly Lys Ser Gln Leu Glu Leu Gln Gln Leu Lys Gln Phe Glu Arg 
            740                 745                 750         


Leu Glu Gln Glu Val Ser Arg Pro Ile Asp His Asp Leu Ala Asn Trp 
        755                 760                 765             


Thr Pro Ala Gln Pro Leu Ala Pro Gly Arg Thr Gly Gly Leu Gly Pro 
    770                 775                 780                 


Ser Asp Arg Gln Leu Leu Leu Phe Tyr Leu Glu Gln Cys Glu Ala Asn 
785                 790                 795                 800 


Leu Thr Thr Leu Thr Asn Ala Val Asp Ala Phe Phe Thr Ala Val Ala 
                805                 810                 815     


Thr Asn Gln Pro Pro Lys Ile Phe Val Ala His Ser Lys Phe Val Ile 
            820                 825                 830         


Leu Ser Ala His Lys Leu Val Phe Ile Gly Asp Thr Leu Ser Arg Gln 
        835                 840                 845             


Ala Lys Ala Ala Asp Val Arg Ser Gln Val Thr His Tyr Ser Asn Leu 
    850                 855                 860                 


Leu Cys Asp Leu Leu Arg Gly Ile Val Ala Thr Thr Lys Ala Ala Ala 
865                 870                 875                 880 


Leu Gln Tyr Pro Ser Pro Ser Ala Ala Gln Asp Met Val Glu Arg Val 
                885                 890                 895     


Lys Glu Leu Gly His Ser Thr Gln Gln Phe Arg Arg Val Leu Gly Gln 
            900                 905                 910         


Leu Ala Ala Ala 
        915     


<210>  1432
<211>  57
<212>  PRT
<213>  Homo Sapiens

<400>  1432

Met Pro Ala Lys Pro Phe Leu Ser Ser Val Leu Leu Ser Trp Lys Val 
1               5                   10                  15      


Leu Asp Phe Ser Gly Pro Gly Pro Gln Gly Thr Gly Gln Pro Cys Ser 
            20                  25                  30          


Cys Gly His Trp Ala Glu Gly Gln Gly Gly Pro Pro Glu Pro Ala Gly 
        35                  40                  45              


Gly Pro Val Ser Gln Gly Ser Ser Asp 
    50                  55          


<210>  1433
<211>  57
<212>  PRT
<213>  Homo Sapiens

<400>  1433

Met Pro Ala Lys Pro Phe Leu Ser Ser Val Leu Leu Ser Trp Lys Val 
1               5                   10                  15      


Leu Asp Phe Ser Gly Pro Gly Pro Gln Gly Thr Gly Gln Pro Cys Ser 
            20                  25                  30          


Cys Gly His Trp Ala Glu Gly Gln Gly Gly Pro Pro Glu Pro Ala Gly 
        35                  40                  45              


Gly Pro Val Ser Gln Gly Ser Ser Asp 
    50                  55          


<210>  1434
<211>  722
<212>  PRT
<213>  Homo Sapiens

<400>  1434

Met Gln Gly Lys Asn Val Leu Ala Lys Ala Leu Tyr Asp Asn Val Ala 
1               5                   10                  15      


Glu Ser Pro Asp Glu Leu Ser Phe Arg Lys Gly Asp Ile Met Thr Val 
            20                  25                  30          


Leu Glu Gln Asp Thr Gln Gly Leu Asp Gly Trp Trp Leu Cys Ser Leu 
        35                  40                  45              


His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys Ile Leu Val 
    50                  55                  60                  


Val Val Pro Thr Arg Val Gly Gln Gly Tyr Val Tyr Glu Ala Ala Gln 
65                  70                  75                  80  


Pro Glu Gln Asp Glu Tyr Asp Ile Pro Arg His Leu Leu Ala Pro Gly 
                85                  90                  95      


Pro Gln Asp Ile Tyr Asp Val Pro Pro Val Arg Gly Leu Leu Pro Ser 
            100                 105                 110         


Gln Tyr Gly Gln Glu Val Tyr Asp Thr Pro Pro Met Ala Val Lys Gly 
        115                 120                 125             


Pro Asn Gly Arg Asp Pro Leu Leu Glu Val Tyr Asp Val Pro Pro Ser 
    130                 135                 140                 


Val Glu Lys Gly Leu Pro Pro Ser Asn His His Ala Val Tyr Asp Val 
145                 150                 155                 160 


Pro Pro Ser Val Ser Lys Asp Val Pro Asp Gly Pro Leu Leu Arg Glu 
                165                 170                 175     


Glu Thr Tyr Asp Val Pro Pro Ala Phe Ala Lys Ala Lys Pro Phe Asp 
            180                 185                 190         


Pro Ala Arg Thr Pro Leu Val Leu Ala Ala Pro Pro Pro Asp Ser Pro 
        195                 200                 205             


Pro Ala Glu Asp Val Tyr Asp Val Pro Pro Pro Ala Pro Asp Leu Tyr 
    210                 215                 220                 


Asp Val Pro Pro Gly Leu Arg Arg Pro Gly Pro Gly Thr Leu Tyr Asp 
225                 230                 235                 240 


Val Pro Arg Glu Arg Val Leu Pro Pro Glu Val Ala Asp Gly Gly Val 
                245                 250                 255     


Val Asp Ser Gly Val Tyr Ala Val Pro Pro Pro Ala Glu Arg Glu Ala 
            260                 265                 270         


Pro Ala Glu Gly Lys Arg Leu Ser Ala Ser Ser Thr Gly Ser Thr Arg 
        275                 280                 285             


Ser Ser Gln Ser Ala Ser Ser Leu Glu Val Ala Gly Pro Gly Arg Glu 
    290                 295                 300                 


Pro Leu Glu Leu Glu Val Ala Val Glu Ala Leu Ala Arg Leu Gln Gln 
305                 310                 315                 320 


Gly Val Ser Ala Thr Val Ala His Leu Leu Asp Leu Ala Gly Ser Ala 
                325                 330                 335     


Gly Ala Thr Gly Ser Trp Arg Ser Pro Ser Glu Pro Gln Glu Pro Leu 
            340                 345                 350         


Val Gln Asp Leu Gln Ala Ala Val Ala Ala Val Gln Ser Ala Val His 
        355                 360                 365             


Glu Leu Leu Glu Phe Ala Arg Ser Ala Val Gly Asn Ala Ala His Thr 
    370                 375                 380                 


Ser Asp Arg Ala Leu His Ala Lys Leu Ser Arg Gln Leu Gln Lys Met 
385                 390                 395                 400 


Glu Asp Val His Gln Thr Leu Val Ala His Gly Gln Ala Leu Asp Ala 
                405                 410                 415     


Gly Arg Gly Gly Ser Gly Ala Thr Leu Glu Asp Leu Asp Arg Leu Val 
            420                 425                 430         


Ala Cys Ser Arg Ala Val Pro Glu Asp Ala Lys Gln Leu Ala Ser Phe 
        435                 440                 445             


Leu His Gly Asn Ala Ser Leu Leu Phe Arg Arg Thr Lys Ala Thr Ala 
    450                 455                 460                 


Pro Gly Pro Glu Gly Gly Gly Thr Leu His Pro Asn Pro Thr Asp Lys 
465                 470                 475                 480 


Thr Ser Ser Ile Gln Ser Arg Pro Leu Pro Ser Pro Pro Lys Phe Thr 
                485                 490                 495     


Ser Gln Asp Ser Pro Asp Gly Gln Tyr Glu Asn Ser Glu Gly Gly Trp 
            500                 505                 510         


Met Glu Asp Tyr Asp Tyr Val His Leu Gln Gly Lys Glu Glu Phe Glu 
        515                 520                 525             


Lys Thr Gln Lys Glu Leu Leu Glu Lys Gly Ser Ile Thr Arg Gln Gly 
    530                 535                 540                 


Lys Ser Gln Leu Glu Leu Gln Gln Leu Lys Gln Phe Glu Arg Leu Glu 
545                 550                 555                 560 


Gln Glu Val Ser Arg Pro Ile Asp His Asp Leu Ala Asn Trp Thr Pro 
                565                 570                 575     


Ala Gln Pro Leu Ala Pro Gly Arg Thr Gly Gly Leu Gly Pro Ser Asp 
            580                 585                 590         


Arg Gln Leu Leu Leu Phe Tyr Leu Glu Gln Cys Glu Ala Asn Leu Thr 
        595                 600                 605             


Thr Leu Thr Asn Ala Val Asp Ala Phe Phe Thr Ala Val Ala Thr Asn 
    610                 615                 620                 


Gln Pro Pro Lys Ile Phe Val Ala His Ser Lys Phe Val Ile Leu Ser 
625                 630                 635                 640 


Ala His Lys Leu Val Phe Ile Gly Asp Thr Leu Ser Arg Gln Ala Lys 
                645                 650                 655     


Ala Ala Asp Val Arg Ser Gln Val Thr His Tyr Ser Asn Leu Leu Cys 
            660                 665                 670         


Asp Leu Leu Arg Gly Ile Val Ala Thr Thr Lys Ala Ala Ala Leu Gln 
        675                 680                 685             


Tyr Pro Ser Pro Ser Ala Ala Gln Asp Met Val Glu Arg Val Lys Glu 
    690                 695                 700                 


Leu Gly His Ser Thr Gln Gln Phe Arg Arg Val Leu Gly Gln Leu Ala 
705                 710                 715                 720 


Ala Ala 
        


<210>  1435
<211>  870
<212>  PRT
<213>  Homo Sapiens

<400>  1435

Met Ser Val Pro Asn Val Leu Ala Lys Ala Leu Tyr Asp Asn Val Ala 
1               5                   10                  15      


Glu Ser Pro Asp Glu Leu Ser Phe Arg Lys Gly Asp Ile Met Thr Val 
            20                  25                  30          


Leu Glu Gln Asp Thr Gln Gly Leu Asp Gly Trp Trp Leu Cys Ser Leu 
        35                  40                  45              


His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys Ile Leu Val 
    50                  55                  60                  


Gly Met Tyr Asp Lys Lys Pro Ala Gly Pro Gly Pro Gly Pro Pro Ala 
65                  70                  75                  80  


Thr Pro Ala Gln Pro Gln Pro Gly Leu His Ala Pro Ala Pro Pro Ala 
                85                  90                  95      


Ser Gln Tyr Thr Pro Met Leu Pro Asn Thr Tyr Gln Pro Gln Pro Asp 
            100                 105                 110         


Ser Val Tyr Leu Val Pro Thr Pro Ser Lys Ala Gln Gln Gly Leu Tyr 
        115                 120                 125             


Gln Val Pro Gly Pro Ser Pro Gln Phe Gln Ser Pro Pro Ala Lys Gln 
    130                 135                 140                 


Thr Ser Thr Phe Ser Lys Gln Thr Pro His His Pro Phe Pro Ser Pro 
145                 150                 155                 160 


Ala Thr Asp Leu Tyr Gln Val Pro Pro Gly Pro Gly Gly Pro Ala Gln 
                165                 170                 175     


Asp Ile Tyr Gln Val Pro Pro Ser Ala Gly Met Gly His Asp Ile Tyr 
            180                 185                 190         


Gln Val Pro Pro Ser Met Asp Thr Arg Ser Trp Glu Gly Thr Lys Pro 
        195                 200                 205             


Pro Ala Lys Val Val Val Pro Thr Arg Val Gly Gln Gly Tyr Val Tyr 
    210                 215                 220                 


Glu Ala Ala Gln Pro Glu Gln Asp Glu Tyr Asp Ile Pro Arg His Leu 
225                 230                 235                 240 


Leu Ala Pro Gly Pro Gln Asp Ile Tyr Asp Val Pro Pro Val Arg Gly 
                245                 250                 255     


Leu Leu Pro Ser Gln Tyr Gly Gln Glu Val Tyr Asp Thr Pro Pro Met 
            260                 265                 270         


Ala Val Lys Gly Pro Asn Gly Arg Asp Pro Leu Leu Glu Val Tyr Asp 
        275                 280                 285             


Val Pro Pro Ser Val Glu Lys Gly Leu Pro Pro Ser Asn His His Ala 
    290                 295                 300                 


Val Tyr Asp Val Pro Pro Ser Val Ser Lys Asp Val Pro Asp Gly Pro 
305                 310                 315                 320 


Leu Leu Arg Glu Glu Thr Tyr Asp Val Pro Pro Ala Phe Ala Lys Ala 
                325                 330                 335     


Lys Pro Phe Asp Pro Ala Arg Thr Pro Leu Val Leu Ala Ala Pro Pro 
            340                 345                 350         


Pro Asp Ser Pro Pro Ala Glu Asp Val Tyr Asp Val Pro Pro Pro Ala 
        355                 360                 365             


Pro Asp Leu Tyr Asp Val Pro Pro Gly Leu Arg Arg Pro Gly Pro Gly 
    370                 375                 380                 


Thr Leu Tyr Asp Val Pro Arg Glu Arg Val Leu Pro Pro Glu Val Ala 
385                 390                 395                 400 


Asp Gly Gly Val Val Asp Ser Gly Val Tyr Ala Val Pro Pro Pro Ala 
                405                 410                 415     


Glu Arg Glu Ala Pro Ala Glu Gly Lys Arg Leu Ser Ala Ser Ser Thr 
            420                 425                 430         


Gly Ser Thr Arg Ser Ser Gln Ser Ala Ser Ser Leu Glu Val Ala Gly 
        435                 440                 445             


Pro Gly Arg Glu Pro Leu Glu Leu Glu Val Ala Val Glu Ala Leu Ala 
    450                 455                 460                 


Arg Leu Gln Gln Gly Val Ser Ala Thr Val Ala His Leu Leu Asp Leu 
465                 470                 475                 480 


Ala Gly Ser Ala Gly Ala Thr Gly Ser Trp Arg Ser Pro Ser Glu Pro 
                485                 490                 495     


Gln Glu Pro Leu Val Gln Asp Leu Gln Ala Ala Val Ala Ala Val Gln 
            500                 505                 510         


Ser Ala Val His Glu Leu Leu Glu Phe Ala Arg Ser Ala Val Gly Asn 
        515                 520                 525             


Ala Ala His Thr Ser Asp Arg Ala Leu His Ala Lys Leu Ser Arg Gln 
    530                 535                 540                 


Leu Gln Lys Met Glu Asp Val His Gln Thr Leu Val Ala His Gly Gln 
545                 550                 555                 560 


Ala Leu Asp Ala Gly Arg Gly Gly Ser Gly Ala Thr Leu Glu Asp Leu 
                565                 570                 575     


Asp Arg Leu Val Ala Cys Ser Arg Ala Val Pro Glu Asp Ala Lys Gln 
            580                 585                 590         


Leu Ala Ser Phe Leu His Gly Asn Ala Ser Leu Leu Phe Arg Arg Thr 
        595                 600                 605             


Lys Ala Thr Ala Pro Gly Pro Glu Gly Gly Gly Thr Leu His Pro Asn 
    610                 615                 620                 


Pro Thr Asp Lys Thr Ser Ser Ile Gln Ser Arg Pro Leu Pro Ser Pro 
625                 630                 635                 640 


Pro Lys Phe Thr Ser Gln Asp Ser Pro Asp Gly Gln Tyr Glu Asn Ser 
                645                 650                 655     


Glu Gly Gly Trp Met Glu Asp Tyr Asp Tyr Val His Leu Gln Gly Lys 
            660                 665                 670         


Glu Glu Phe Glu Lys Thr Gln Lys Glu Leu Leu Glu Lys Gly Ser Ile 
        675                 680                 685             


Thr Arg Gln Gly Lys Ser Gln Leu Glu Leu Gln Gln Leu Lys Gln Phe 
    690                 695                 700                 


Glu Arg Leu Glu Gln Glu Val Ser Arg Pro Ile Asp His Asp Leu Ala 
705                 710                 715                 720 


Asn Trp Thr Pro Ala Gln Pro Leu Ala Pro Gly Arg Thr Gly Gly Leu 
                725                 730                 735     


Gly Pro Ser Asp Arg Gln Leu Leu Leu Phe Tyr Leu Glu Gln Cys Glu 
            740                 745                 750         


Ala Asn Leu Thr Thr Leu Thr Asn Ala Val Asp Ala Phe Phe Thr Ala 
        755                 760                 765             


Val Ala Thr Asn Gln Pro Pro Lys Ile Phe Val Ala His Ser Lys Phe 
    770                 775                 780                 


Val Ile Leu Ser Ala His Lys Leu Val Phe Ile Gly Asp Thr Leu Ser 
785                 790                 795                 800 


Arg Gln Ala Lys Ala Ala Asp Val Arg Ser Gln Val Thr His Tyr Ser 
                805                 810                 815     


Asn Leu Leu Cys Asp Leu Leu Arg Gly Ile Val Ala Thr Thr Lys Ala 
            820                 825                 830         


Ala Ala Leu Gln Tyr Pro Ser Pro Ser Ala Ala Gln Asp Met Val Glu 
        835                 840                 845             


Arg Val Lys Glu Leu Gly His Ser Thr Gln Gln Phe Arg Arg Val Leu 
    850                 855                 860                 


Gly Gln Leu Ala Ala Ala 
865                 870 


<210>  1436
<211>  50
<212>  PRT
<213>  Homo Sapiens

<400>  1436

Met Thr Val Leu Glu Gln Asp Thr Gln Gly Leu Asp Gly Trp Trp Leu 
1               5                   10                  15      


Cys Ser Leu His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys 
            20                  25                  30          


Ile Leu Val Gly Met Tyr Asp Lys Lys Pro Ala Gly Pro Gly Pro Gly 
        35                  40                  45              


Pro Pro 
    50  


<210>  1437
<211>  59
<212>  PRT
<213>  Homo Sapiens

<400>  1437

Met Thr Val Leu Glu Gln Asp Thr Gln Gly Leu Asp Gly Trp Trp Leu 
1               5                   10                  15      


Cys Ser Leu His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys 
            20                  25                  30          


Ile Leu Val Gly Met Tyr Asp Lys Lys Pro Ala Gly Pro Gly Pro Gly 
        35                  40                  45              


Pro Pro Ala Thr Pro Ala Gln Pro Gln Pro Gly 
    50                  55                  


<210>  1438
<211>  80
<212>  PRT
<213>  Homo Sapiens

<400>  1438

Met Thr Val Leu Glu Gln Asp Thr Gln Gly Leu Asp Gly Trp Trp Leu 
1               5                   10                  15      


Cys Ser Leu His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys 
            20                  25                  30          


Ile Leu Val Gly Met Tyr Asp Lys Lys Pro Ala Gly Pro Gly Pro Gly 
        35                  40                  45              


Pro Pro Ala Thr Pro Ala Gln Pro Gln Pro Gly Leu His Ala Pro Ala 
    50                  55                  60                  


Pro Pro Ala Ser Gln Tyr Thr Pro Met Leu Pro Asn Thr Tyr Gln Pro 
65                  70                  75                  80  


<210>  1439
<211>  120
<212>  PRT
<213>  Homo Sapiens

<400>  1439

Met Thr Val Leu Glu Gln Asp Thr Gln Gly Leu Asp Gly Trp Trp Leu 
1               5                   10                  15      


Cys Ser Leu His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys 
            20                  25                  30          


Ile Leu Val Gly Met Tyr Asp Lys Lys Pro Ala Gly Pro Gly Pro Gly 
        35                  40                  45              


Pro Pro Ala Thr Pro Ala Gln Pro Gln Pro Gly Leu His Ala Pro Ala 
    50                  55                  60                  


Pro Pro Ala Ser Gln Tyr Thr Pro Met Leu Pro Asn Thr Tyr Gln Pro 
65                  70                  75                  80  


Gln Pro Asp Ser Val Tyr Leu Val Pro Thr Pro Ser Lys Ala Gln Gln 
                85                  90                  95      


Gly Leu Tyr Gln Val Pro Gly Pro Ser Pro Gln Phe Gln Ser Pro Pro 
            100                 105                 110         


Ala Lys Gln Thr Ser Thr Phe Ser 
        115                 120 


<210>  1440
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  1440

Met Thr Val Leu Glu Gln Asp Thr Gln Gly Leu Asp Gly Trp Trp Leu 
1               5                   10                  15      


Cys Ser Leu His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys 
            20                  25                  30          


Ile Leu Val Gly Met Tyr Asp Lys Lys Pro Ala Gly Pro Gly Pro Gly 
        35                  40                  45              


Pro Pro Ala Thr Pro Ala Gln Pro Gln Pro Gly Leu His Ala Pro Ala 
    50                  55                  60                  


Pro Pro Ala Ser Gln Tyr Thr Pro Met Leu Pro Asn Thr Tyr Gln Pro 
65                  70                  75                  80  


Gln Pro Asp Ser Val Tyr Leu Val Pro Thr Pro Ser Lys Ala Gln Gln 
                85                  90                  95      


Gly Leu Tyr Gln Val Pro Gly Pro Ser Pro Gln Phe Gln Ser Pro Pro 
            100                 105                 110         


Ala Lys Gln Thr Ser Thr Phe Ser Lys Gln Thr Pro His His Pro Phe 
        115                 120                 125             


<210>  1441
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  1441

Met Thr Val Leu Glu Gln Asp Thr Gln Gly Leu Asp Gly Trp Trp Leu 
1               5                   10                  15      


Cys Ser Leu His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys 
            20                  25                  30          


Ile Leu Val Gly Met Tyr Asp Lys Lys Pro Ala Gly Pro Gly Pro Gly 
        35                  40                  45              


Pro Pro Ala Thr Pro Ala Gln Pro Gln Pro Gly Leu His Ala Pro Ala 
    50                  55                  60                  


Pro Pro Ala Ser Gln Tyr Thr Pro Met Leu Pro Asn Thr Tyr Gln Pro 
65                  70                  75                  80  


Gln Pro Asp Ser Val Tyr Leu Val Pro Thr Pro Ser Lys Ala Gln Gln 
                85                  90                  95      


Gly Leu Tyr Gln Val Pro Gly Pro Ser Pro Gln Phe Gln Ser Pro Pro 
            100                 105                 110         


Ala Lys Gln Thr Ser Thr Phe Ser Lys Gln Thr Pro His His Pro Phe 
        115                 120                 125             


Pro Ser Pro Ala Thr 
    130             


<210>  1442
<211>  135
<212>  PRT
<213>  Homo Sapiens

<400>  1442

Met Thr Val Leu Glu Gln Asp Thr Gln Gly Leu Asp Gly Trp Trp Leu 
1               5                   10                  15      


Cys Ser Leu His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys 
            20                  25                  30          


Ile Leu Val Gly Met Tyr Asp Lys Lys Pro Ala Gly Pro Gly Pro Gly 
        35                  40                  45              


Pro Pro Ala Thr Pro Ala Gln Pro Gln Pro Gly Leu His Ala Pro Ala 
    50                  55                  60                  


Pro Pro Ala Ser Gln Tyr Thr Pro Met Leu Pro Asn Thr Tyr Gln Pro 
65                  70                  75                  80  


Gln Pro Asp Ser Val Tyr Leu Val Pro Thr Pro Ser Lys Ala Gln Gln 
                85                  90                  95      


Gly Leu Tyr Gln Val Pro Gly Pro Ser Pro Gln Phe Gln Ser Pro Pro 
            100                 105                 110         


Ala Lys Gln Thr Ser Thr Phe Ser Lys Gln Thr Pro His His Pro Phe 
        115                 120                 125             


Pro Ser Pro Ala Thr Asp Leu 
    130                 135 


<210>  1443
<211>  238
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1443

Xaa Pro Gln Phe Gln Ser Pro Pro Ala Lys Gln Thr Ser Thr Phe Ser 
1               5                   10                  15      


Lys Gln Thr Pro His His Pro Phe Pro Ser Pro Ala Thr Asp Leu Tyr 
            20                  25                  30          


Gln Val Pro Pro Gly Pro Gly Gly Pro Ala Gln Asp Ile Tyr Gln Val 
        35                  40                  45              


Pro Pro Ser Ala Gly Met Gly His Asp Ile Tyr Gln Val Pro Pro Ser 
    50                  55                  60                  


Met Asp Thr Arg Ser Trp Glu Gly Thr Lys Pro Pro Ala Lys Val Val 
65                  70                  75                  80  


Val Pro Thr Arg Val Gly Gln Gly Tyr Val Tyr Glu Ala Ala Gln Pro 
                85                  90                  95      


Glu Gln Asp Glu Tyr Asp Ile Pro Arg His Leu Leu Ala Pro Gly Pro 
            100                 105                 110         


Gln Asp Ile Tyr Asp Val Pro Pro Val Arg Gly Leu Leu Pro Ser Gln 
        115                 120                 125             


Tyr Gly Gln Glu Val Tyr Asp Val Pro Pro Ser Val Ser Lys Asp Val 
    130                 135                 140                 


Pro Asp Gly Pro Leu Leu Arg Glu Glu Thr Tyr Asp Val Pro Pro Ala 
145                 150                 155                 160 


Phe Ala Lys Ala Lys Pro Phe Asp Pro Ala Arg Thr Pro Leu Val Leu 
                165                 170                 175     


Ala Ala Pro Pro Pro Asp Ser Pro Pro Ala Glu Asp Val Tyr Asp Val 
            180                 185                 190         


Pro Pro Pro Ala Pro Asp Leu Tyr Asp Val Pro Pro Gly Leu Arg Arg 
        195                 200                 205             


Pro Gly Pro Gly Thr Leu Tyr Asp Val Pro Arg Glu Arg Val Leu Pro 
    210                 215                 220                 


Pro Glu Val Ala Asp Gly Gly Val Val Asp Ser Gly Val Tyr 
225                 230                 235             


<210>  1444
<211>  120
<212>  PRT
<213>  Homo Sapiens

<400>  1444

Ala Val Gln Phe Thr Gly Trp Ser Ser Ser Cys Ile Leu His Phe Pro 
1               5                   10                  15      


Glu Val Leu His Asp Phe His Ser Leu Gln Thr Leu Pro Ser Leu Leu 
            20                  25                  30          


Gln Arg Ile Gly Asn Pro Asn Glu Thr Gln Asn Asn Ser Thr Ser Trp 
        35                  40                  45              


Pro Val Phe Lys Ser Thr Glu Gln Lys Tyr Leu Thr Leu Asn Thr Glu 
    50                  55                  60                  


Ser Thr Arg Ile Met Thr Lys Leu Arg Ala Gln Gln Cys Arg Phe Trp 
65                  70                  75                  80  


Thr Ser Phe Phe Pro Lys Val Leu Glu Met Thr Glu Pro Ile Cys Cys 
                85                  90                  95      


Tyr Cys Glu Pro Gly Thr Ala Leu Ala Ala Arg Ala Ala Gln Met Lys 
            100                 105                 110         


Met Thr Gly Ser Ala Tyr Ser Gln 
        115                 120 


<210>  1445
<211>  132
<212>  PRT
<213>  Homo Sapiens

<400>  1445

Ala Val Gln Phe Thr Gly Trp Ser Ser Ser Cys Ile Leu His Phe Pro 
1               5                   10                  15      


Glu Val Leu His Asp Phe His Ser Leu Gln Thr Leu Pro Ser Leu Leu 
            20                  25                  30          


Gln Arg Ile Gly Asn Pro Asn Glu Thr Gln Asn Asn Ser Thr Ser Trp 
        35                  40                  45              


Pro Val Phe Lys Ser Thr Glu Gln Lys Tyr Leu Thr Leu Asn Thr Glu 
    50                  55                  60                  


Ser Thr Arg Ile Met Thr Lys Leu Arg Ala Gln Gln Cys Arg Phe Trp 
65                  70                  75                  80  


Thr Ser Phe Phe Pro Lys Val Leu Glu Met Thr Gly Asn Ile Asp Glu 
                85                  90                  95      


Ala Glu Trp Glu Trp Lys Ala Gly Phe His Arg Trp Asn Asn Tyr Met 
            100                 105                 110         


Met Asp Trp Lys Asn Gln Phe Asn Asp Tyr Thr Ser Lys Lys Glu Ser 
        115                 120                 125             


Cys Val Gly Leu 
    130         


<210>  1446
<211>  602
<212>  PRT
<213>  Homo Sapiens

<400>  1446

Met His Ser Lys Val Thr Ile Ile Cys Ile Arg Phe Leu Phe Trp Phe 
1               5                   10                  15      


Leu Leu Leu Cys Met Leu Ile Gly Lys Ser His Thr Glu Asp Asp Ile 
            20                  25                  30          


Ile Ile Ala Thr Lys Asn Gly Lys Val Arg Gly Met Asn Leu Thr Val 
        35                  40                  45              


Phe Gly Gly Thr Val Thr Ala Phe Leu Gly Ile Pro Tyr Ala Gln Pro 
    50                  55                  60                  


Pro Leu Gly Arg Leu Arg Phe Lys Lys Pro Gln Ser Leu Thr Lys Trp 
65                  70                  75                  80  


Ser Asp Ile Trp Asn Ala Thr Lys Tyr Ala Asn Ser Cys Cys Gln Asn 
                85                  90                  95      


Ile Asp Gln Ser Phe Pro Gly Phe His Gly Ser Glu Met Trp Asn Pro 
            100                 105                 110         


Asn Thr Asp Leu Ser Glu Asp Cys Leu Tyr Leu Asn Val Trp Ile Pro 
        115                 120                 125             


Ala Pro Lys Pro Lys Asn Ala Thr Val Leu Ile Trp Ile Tyr Gly Gly 
    130                 135                 140                 


Gly Phe Gln Thr Gly Thr Ser Ser Leu His Val Tyr Asp Gly Lys Phe 
145                 150                 155                 160 


Leu Ala Arg Val Glu Arg Val Ile Val Val Ser Met Asn Tyr Arg Val 
                165                 170                 175     


Gly Ala Leu Gly Phe Leu Ala Leu Pro Gly Asn Pro Glu Ala Pro Gly 
            180                 185                 190         


Asn Met Gly Leu Phe Asp Gln Gln Leu Ala Leu Gln Trp Val Gln Lys 
        195                 200                 205             


Asn Ile Ala Ala Phe Gly Gly Asn Pro Lys Ser Val Thr Leu Phe Gly 
    210                 215                 220                 


Glu Ser Ala Gly Ala Ala Ser Val Ser Leu His Leu Leu Ser Pro Gly 
225                 230                 235                 240 


Ser His Ser Leu Phe Thr Arg Ala Ile Leu Gln Ser Gly Ser Phe Asn 
                245                 250                 255     


Ala Pro Trp Ala Val Thr Ser Leu Tyr Glu Ala Arg Asn Arg Thr Leu 
            260                 265                 270         


Asn Leu Ala Lys Leu Thr Gly Cys Ser Arg Glu Asn Glu Thr Glu Ile 
        275                 280                 285             


Ile Lys Cys Leu Arg Asn Lys Asp Pro Gln Glu Ile Leu Leu Asn Glu 
    290                 295                 300                 


Ala Phe Val Val Pro Tyr Gly Thr Pro Leu Ser Val Asn Phe Gly Pro 
305                 310                 315                 320 


Thr Val Asp Gly Asp Phe Leu Thr Asp Met Pro Asp Ile Leu Leu Glu 
                325                 330                 335     


Leu Gly Gln Phe Lys Lys Thr Gln Ile Leu Val Gly Val Asn Lys Asp 
            340                 345                 350         


Glu Gly Thr Ala Phe Leu Val Tyr Gly Ala Pro Gly Phe Ser Lys Asp 
        355                 360                 365             


Asn Asn Ser Ile Ile Thr Arg Lys Glu Phe Gln Glu Gly Leu Lys Ile 
    370                 375                 380                 


Phe Phe Pro Gly Val Ser Glu Phe Gly Lys Glu Ser Ile Leu Phe His 
385                 390                 395                 400 


Tyr Thr Asp Trp Val Asp Asp Gln Arg Pro Glu Asn Tyr Arg Glu Ala 
                405                 410                 415     


Leu Gly Asp Val Val Gly Asp Tyr Asn Phe Ile Cys Pro Ala Leu Glu 
            420                 425                 430         


Phe Thr Lys Lys Phe Ser Glu Trp Gly Asn Asn Ala Phe Phe Tyr Tyr 
        435                 440                 445             


Phe Glu His Arg Ser Ser Lys Leu Pro Trp Pro Glu Trp Met Gly Val 
    450                 455                 460                 


Met His Gly Tyr Glu Ile Glu Phe Val Phe Gly Leu Pro Leu Glu Arg 
465                 470                 475                 480 


Arg Asp Asn Tyr Thr Lys Ala Glu Glu Ile Leu Ser Arg Ser Ile Val 
                485                 490                 495     


Lys Arg Trp Ala Asn Phe Ala Lys Tyr Gly Asn Pro Asn Glu Thr Gln 
            500                 505                 510         


Asn Asn Ser Thr Ser Trp Pro Val Phe Lys Ser Thr Glu Gln Lys Tyr 
        515                 520                 525             


Leu Thr Leu Asn Thr Glu Ser Thr Arg Ile Met Thr Lys Leu Arg Ala 
    530                 535                 540                 


Gln Gln Cys Arg Phe Trp Thr Ser Phe Phe Pro Lys Val Leu Glu Met 
545                 550                 555                 560 


Thr Gly Asn Ile Asp Glu Ala Glu Trp Glu Trp Lys Ala Gly Phe His 
                565                 570                 575     


Arg Trp Asn Asn Tyr Met Met Asp Trp Lys Asn Gln Phe Asn Asp Tyr 
            580                 585                 590         


Thr Ser Lys Lys Glu Ser Cys Val Gly Leu 
        595                 600         


<210>  1447
<211>  525
<212>  PRT
<213>  Homo Sapiens

<400>  1447

Met His Ser Lys Val Thr Ile Ile Cys Ile Arg Phe Leu Phe Trp Phe 
1               5                   10                  15      


Leu Leu Leu Cys Met Leu Ile Gly Lys Ser His Thr Glu Asp Asp Ile 
            20                  25                  30          


Ile Ile Ala Thr Lys Asn Gly Lys Val Arg Gly Met Asn Leu Thr Val 
        35                  40                  45              


Phe Gly Gly Thr Val Thr Ala Phe Leu Gly Ile Pro Tyr Ala Gln Pro 
    50                  55                  60                  


Pro Leu Gly Arg Leu Arg Phe Lys Lys Pro Gln Ser Leu Thr Lys Trp 
65                  70                  75                  80  


Ser Asp Ile Trp Asn Ala Thr Lys Tyr Ala Asn Ser Cys Cys Gln Asn 
                85                  90                  95      


Ile Asp Gln Ser Phe Pro Gly Phe His Gly Ser Glu Met Trp Asn Pro 
            100                 105                 110         


Asn Thr Asp Leu Ser Glu Asp Cys Leu Tyr Leu Asn Val Trp Ile Pro 
        115                 120                 125             


Ala Pro Lys Pro Lys Asn Ala Thr Val Leu Ile Trp Ile Tyr Gly Gly 
    130                 135                 140                 


Gly Phe Gln Thr Gly Thr Ser Ser Leu His Val Tyr Asp Gly Lys Phe 
145                 150                 155                 160 


Leu Ala Arg Val Glu Arg Val Ile Val Val Ser Met Asn Tyr Arg Val 
                165                 170                 175     


Gly Ala Leu Gly Phe Leu Ala Leu Pro Gly Asn Pro Glu Ala Pro Gly 
            180                 185                 190         


Asn Met Gly Leu Phe Asp Gln Gln Leu Ala Leu Gln Trp Val Gln Lys 
        195                 200                 205             


Asn Ile Ala Ala Phe Gly Gly Asn Pro Lys Ser Val Thr Leu Phe Gly 
    210                 215                 220                 


Glu Ser Ala Gly Ala Ala Ser Val Ser Leu His Leu Leu Ser Pro Gly 
225                 230                 235                 240 


Ser His Ser Leu Phe Thr Arg Ala Ile Leu Gln Ser Gly Ser Phe Asn 
                245                 250                 255     


Ala Pro Trp Ala Val Thr Ser Leu Tyr Glu Ala Arg Asn Arg Thr Leu 
            260                 265                 270         


Asn Leu Ala Lys Leu Thr Gly Cys Ser Arg Glu Asn Glu Thr Glu Ile 
        275                 280                 285             


Ile Lys Cys Leu Arg Asn Lys Asp Pro Gln Glu Ile Leu Leu Asn Glu 
    290                 295                 300                 


Ala Phe Val Val Pro Tyr Gly Thr Pro Leu Ser Val Asn Phe Gly Pro 
305                 310                 315                 320 


Thr Val Asp Gly Asp Phe Leu Thr Asp Met Pro Asp Ile Leu Leu Glu 
                325                 330                 335     


Leu Gly Gln Phe Lys Lys Thr Gln Ile Leu Val Gly Val Asn Lys Asp 
            340                 345                 350         


Glu Gly Thr Ala Phe Leu Val Tyr Gly Ala Pro Gly Phe Ser Lys Asp 
        355                 360                 365             


Asn Asn Ser Ile Ile Thr Arg Lys Glu Phe Gln Glu Gly Leu Lys Ile 
    370                 375                 380                 


Phe Phe Pro Gly Val Ser Glu Phe Gly Lys Glu Ser Ile Leu Phe His 
385                 390                 395                 400 


Tyr Thr Asp Trp Val Asp Asp Gln Arg Pro Glu Asn Tyr Arg Glu Ala 
                405                 410                 415     


Leu Gly Asp Val Val Gly Asp Tyr Asn Phe Ile Cys Pro Ala Leu Glu 
            420                 425                 430         


Phe Thr Lys Lys Phe Ser Glu Trp Gly Asn Asn Ala Phe Phe Tyr Tyr 
        435                 440                 445             


Phe Glu His Arg Ser Ser Lys Leu Pro Trp Pro Glu Trp Met Gly Val 
    450                 455                 460                 


Met His Gly Tyr Glu Ile Glu Phe Val Phe Gly Leu Pro Leu Glu Arg 
465                 470                 475                 480 


Arg Asp Asn Tyr Thr Lys Ala Glu Glu Ile Leu Ser Arg Ser Ile Val 
                485                 490                 495     


Lys Arg Trp Ala Asn Phe Ala Lys Tyr Gly Cys Ser Ser Ser Thr Ile 
            500                 505                 510         


Leu Asn Tyr Val Leu Glu Thr Glu Pro Val Val Leu Ile 
        515                 520                 525 


<210>  1448
<211>  562
<212>  PRT
<213>  Homo Sapiens

<400>  1448

Met His Ser Lys Val Thr Ile Ile Cys Ile Arg Phe Leu Phe Trp Phe 
1               5                   10                  15      


Leu Leu Leu Cys Met Leu Ile Gly Lys Ser His Thr Glu Asp Asp Ile 
            20                  25                  30          


Ile Ile Ala Thr Lys Asn Gly Lys Val Arg Gly Met Asn Leu Thr Val 
        35                  40                  45              


Phe Gly Gly Thr Val Thr Ala Phe Leu Gly Ile Pro Tyr Ala Gln Pro 
    50                  55                  60                  


Pro Leu Gly Arg Leu Arg Phe Lys Lys Pro Gln Ser Leu Thr Lys Trp 
65                  70                  75                  80  


Ser Asp Ile Trp Asn Ala Thr Lys Tyr Ala Asn Ser Cys Cys Gln Asn 
                85                  90                  95      


Ile Asp Gln Ser Phe Pro Gly Phe His Gly Ser Glu Met Trp Asn Pro 
            100                 105                 110         


Asn Thr Asp Leu Ser Glu Asp Cys Leu Tyr Leu Asn Val Trp Ile Pro 
        115                 120                 125             


Ala Pro Lys Pro Lys Asn Ala Thr Val Leu Ile Trp Ile Tyr Gly Gly 
    130                 135                 140                 


Gly Phe Gln Thr Gly Thr Ser Ser Leu His Val Tyr Asp Gly Lys Phe 
145                 150                 155                 160 


Leu Ala Arg Val Glu Arg Val Ile Val Val Ser Met Asn Tyr Arg Val 
                165                 170                 175     


Gly Ala Leu Gly Phe Leu Ala Leu Pro Gly Asn Pro Glu Ala Pro Gly 
            180                 185                 190         


Asn Met Gly Leu Phe Asp Gln Gln Leu Ala Leu Gln Trp Val Gln Lys 
        195                 200                 205             


Asn Ile Ala Ala Phe Gly Gly Asn Pro Lys Ser Val Thr Leu Phe Gly 
    210                 215                 220                 


Glu Ser Ala Gly Ala Ala Ser Val Ser Leu His Leu Leu Ser Pro Gly 
225                 230                 235                 240 


Ser His Ser Leu Phe Thr Arg Ala Ile Leu Gln Ser Gly Ser Phe Asn 
                245                 250                 255     


Ala Pro Trp Ala Val Thr Ser Leu Tyr Glu Ala Arg Asn Arg Thr Leu 
            260                 265                 270         


Asn Leu Ala Lys Leu Thr Gly Cys Ser Arg Glu Asn Glu Thr Glu Ile 
        275                 280                 285             


Ile Lys Cys Leu Arg Asn Lys Asp Pro Gln Glu Ile Leu Leu Asn Glu 
    290                 295                 300                 


Ala Phe Val Val Pro Tyr Gly Thr Pro Leu Ser Val Asn Phe Gly Pro 
305                 310                 315                 320 


Thr Val Asp Gly Asp Phe Leu Thr Asp Met Pro Asp Ile Leu Leu Glu 
                325                 330                 335     


Leu Gly Gln Phe Lys Lys Thr Gln Ile Leu Val Gly Val Asn Lys Asp 
            340                 345                 350         


Glu Gly Thr Ala Phe Leu Val Tyr Gly Ala Pro Gly Phe Ser Lys Asp 
        355                 360                 365             


Asn Asn Ser Ile Ile Thr Arg Lys Glu Phe Gln Glu Gly Leu Lys Ile 
    370                 375                 380                 


Phe Phe Pro Gly Val Ser Glu Phe Gly Lys Glu Ser Ile Leu Phe His 
385                 390                 395                 400 


Tyr Thr Asp Trp Val Asp Asp Gln Arg Pro Glu Asn Tyr Arg Glu Ala 
                405                 410                 415     


Leu Gly Asp Val Val Gly Asp Tyr Asn Phe Ile Cys Pro Ala Leu Glu 
            420                 425                 430         


Phe Thr Lys Lys Phe Ser Glu Trp Gly Asn Asn Ala Phe Phe Tyr Tyr 
        435                 440                 445             


Phe Glu His Arg Ser Ser Lys Leu Pro Trp Pro Glu Trp Met Gly Val 
    450                 455                 460                 


Met His Gly Tyr Glu Ile Glu Phe Val Phe Gly Leu Pro Leu Glu Arg 
465                 470                 475                 480 


Arg Asp Asn Tyr Thr Lys Ala Glu Glu Ile Leu Ser Arg Ser Ile Val 
                485                 490                 495     


Lys Arg Trp Ala Asn Phe Ala Lys Tyr Gly Asn Pro Asn Glu Thr Gln 
            500                 505                 510         


Asn Asn Ser Thr Ser Trp Pro Val Phe Lys Ser Thr Glu Gln Lys Tyr 
        515                 520                 525             


Leu Thr Leu Asn Thr Glu Ser Thr Arg Ile Met Thr Lys Leu Arg Ala 
    530                 535                 540                 


Gln Gln Cys Arg Phe Trp Thr Ser Phe Phe Pro Lys Val Leu Glu Met 
545                 550                 555                 560 


Thr Gly 
        


<210>  1449
<211>  218
<212>  PRT
<213>  Homo Sapiens

<400>  1449

Met Ala Val Val Ala Ala Ala Ala Gly Trp Leu Leu Arg Leu Arg Ala 
1               5                   10                  15      


Ala Gly Ala Glu Gly His Trp Arg Arg Leu Pro Gly Ala Gly Leu Ala 
            20                  25                  30          


Arg Gly Phe Leu His Pro Ala Ala Thr Val Glu Asp Ala Ala Gln Arg 
        35                  40                  45              


Arg Gln Val Ala His Phe Thr Phe Gln Pro Asp Pro Glu Pro Arg Glu 
    50                  55                  60                  


Tyr Gly Gln Thr Gln Lys Met Asn Leu Phe Gln Ser Val Thr Ser Ala 
65                  70                  75                  80  


Leu Asp Asn Ser Leu Ala Lys Asp Pro Thr Ala Val Ile Phe Gly Glu 
                85                  90                  95      


Asp Val Ala Phe Gly Gly Val Phe Arg Cys Thr Val Gly Leu Arg Asp 
            100                 105                 110         


Lys Tyr Gly Lys Asp Arg Val Phe Asn Thr Pro Leu Cys Glu Gln Gly 
        115                 120                 125             


Ile Val Gly Phe Gly Ile Gly Ile Ala Val Thr Gly Ala Thr Ala Ile 
    130                 135                 140                 


Ala Glu Ile Gln Phe Ala Asp Tyr Ile Phe Pro Ala Phe Asp Gln Ile 
145                 150                 155                 160 


Val Asn Glu Ala Ala Lys Tyr Arg Tyr Arg Ser Gly Asp Leu Phe Asn 
                165                 170                 175     


Cys Gly Ser Leu Thr Ile Arg Ser Pro Trp Gly Cys Val Gly His Gly 
            180                 185                 190         


Ala Leu Tyr His Ser Gln Ser Pro Glu Ala Phe Phe Ala His Cys Pro 
        195                 200                 205             


Gly Ile Lys Ile Lys Val Ile Ser Leu Ser 
    210                 215             


<210>  1450
<211>  392
<212>  PRT
<213>  Homo Sapiens

<400>  1450

Met Ala Val Val Ala Ala Ala Ala Gly Trp Leu Leu Arg Leu Arg Ala 
1               5                   10                  15      


Ala Gly Ala Glu Gly His Trp Arg Arg Leu Pro Gly Ala Gly Leu Ala 
            20                  25                  30          


Arg Gly Phe Leu His Pro Ala Ala Thr Val Glu Asp Ala Ala Gln Arg 
        35                  40                  45              


Arg Gln Val Ala His Phe Thr Phe Gln Pro Asp Pro Glu Pro Arg Glu 
    50                  55                  60                  


Tyr Gly Gln Thr Gln Lys Met Asn Leu Phe Gln Ser Val Thr Ser Ala 
65                  70                  75                  80  


Leu Asp Asn Ser Leu Ala Lys Asp Pro Thr Ala Val Ile Phe Gly Glu 
                85                  90                  95      


Asp Val Ala Phe Gly Gly Val Phe Arg Cys Thr Val Gly Leu Arg Asp 
            100                 105                 110         


Lys Tyr Gly Lys Asp Arg Val Phe Asn Thr Pro Leu Cys Glu Gln Gly 
        115                 120                 125             


Ile Val Gly Phe Gly Ile Gly Ile Ala Val Thr Gly Ala Thr Ala Ile 
    130                 135                 140                 


Ala Glu Ile Gln Phe Ala Asp Tyr Ile Phe Pro Ala Phe Asp Gln Ile 
145                 150                 155                 160 


Val Asn Glu Ala Ala Lys Tyr Arg Tyr Arg Ser Gly Asp Leu Phe Asn 
                165                 170                 175     


Cys Gly Ser Leu Thr Ile Arg Ser Pro Trp Gly Cys Val Gly His Gly 
            180                 185                 190         


Ala Leu Tyr His Ser Gln Ser Pro Glu Ala Phe Phe Ala His Cys Pro 
        195                 200                 205             


Gly Ile Lys Val Val Ile Pro Arg Ser Pro Phe Gln Ala Lys Gly Leu 
    210                 215                 220                 


Leu Leu Ser Cys Ile Glu Asp Lys Asn Pro Cys Ile Phe Phe Glu Pro 
225                 230                 235                 240 


Lys Ile Leu Tyr Arg Ala Ala Ala Glu Glu Val Pro Ile Glu Pro Tyr 
                245                 250                 255     


Asn Ile Pro Leu Ser Gln Ala Glu Val Ile Gln Glu Gly Ser Asp Val 
            260                 265                 270         


Thr Leu Val Ala Trp Gly Thr Gln Val His Val Ile Arg Glu Val Ala 
        275                 280                 285             


Ser Met Ala Lys Glu Lys Leu Gly Val Ser Cys Glu Val Ile Asp Leu 
    290                 295                 300                 


Arg Thr Ile Ile Pro Trp Asp Val Asp Thr Ile Cys Lys Ser Val Ile 
305                 310                 315                 320 


Lys Thr Gly Arg Leu Leu Ile Ser His Glu Ala Pro Leu Thr Gly Gly 
                325                 330                 335     


Phe Ala Ser Glu Ile Ser Ser Thr Val Gln Glu Glu Cys Phe Leu Asn 
            340                 345                 350         


Leu Glu Ala Pro Ile Ser Arg Val Cys Gly Tyr Asp Thr Pro Phe Pro 
        355                 360                 365             


His Ile Phe Glu Pro Phe Tyr Ile Pro Asp Lys Trp Lys Cys Tyr Asp 
    370                 375                 380                 


Ala Leu Arg Lys Met Ile Asn Tyr 
385                 390         


<210>  1451
<211>  392
<212>  PRT
<213>  Homo Sapiens

<400>  1451

Met Ala Val Val Ala Ala Ala Ala Gly Trp Leu Leu Arg Leu Arg Ala 
1               5                   10                  15      


Ala Gly Ala Glu Gly His Trp Arg Arg Leu Pro Gly Ala Gly Leu Ala 
            20                  25                  30          


Arg Gly Phe Leu His Pro Ala Ala Thr Val Glu Asp Ala Ala Gln Arg 
        35                  40                  45              


Arg Gln Val Ala His Phe Thr Phe Gln Pro Asp Pro Glu Pro Arg Glu 
    50                  55                  60                  


Tyr Gly Gln Thr Gln Lys Met Asn Leu Phe Gln Ser Val Thr Ser Ala 
65                  70                  75                  80  


Leu Asp Asn Ser Leu Ala Lys Asp Pro Thr Ala Val Ile Phe Gly Glu 
                85                  90                  95      


Asp Val Ala Phe Gly Gly Val Phe Arg Cys Thr Val Gly Leu Arg Asp 
            100                 105                 110         


Lys Tyr Gly Lys Asp Arg Val Phe Asn Thr Pro Leu Cys Glu Gln Gly 
        115                 120                 125             


Ile Val Gly Phe Gly Ile Gly Ile Ala Val Thr Gly Ala Thr Ala Ile 
    130                 135                 140                 


Ala Glu Ile Gln Phe Ala Asp Tyr Ile Phe Pro Ala Phe Asp Gln Ile 
145                 150                 155                 160 


Val Asn Glu Ala Ala Lys Tyr Arg Tyr Arg Ser Gly Asp Leu Phe Asn 
                165                 170                 175     


Cys Gly Ser Leu Thr Ile Arg Ser Pro Trp Gly Cys Val Gly His Gly 
            180                 185                 190         


Ala Leu Tyr His Ser Gln Ser Pro Glu Ala Phe Phe Ala His Cys Pro 
        195                 200                 205             


Gly Ile Lys Val Val Ile Pro Arg Ser Pro Phe Gln Ala Lys Gly Leu 
    210                 215                 220                 


Leu Leu Ser Cys Ile Glu Asp Lys Asn Pro Cys Ile Phe Phe Glu Pro 
225                 230                 235                 240 


Lys Ile Leu Tyr Arg Ala Ala Ala Glu Glu Val Pro Ile Glu Pro Tyr 
                245                 250                 255     


Asn Ile Pro Leu Ser Gln Ala Glu Val Ile Gln Glu Gly Ser Asp Val 
            260                 265                 270         


Thr Leu Val Ala Trp Gly Thr Gln Val His Val Ile Arg Glu Val Ala 
        275                 280                 285             


Ser Met Ala Lys Glu Lys Leu Gly Val Ser Cys Glu Val Ile Asp Leu 
    290                 295                 300                 


Arg Thr Ile Ile Pro Trp Asp Val Asp Thr Ile Cys Lys Ser Val Ile 
305                 310                 315                 320 


Lys Thr Gly Arg Leu Leu Ile Ser His Glu Ala Pro Leu Thr Gly Gly 
                325                 330                 335     


Phe Ala Ser Glu Ile Ser Ser Thr Val Gln Glu Glu Cys Phe Leu Asn 
            340                 345                 350         


Leu Glu Ala Pro Ile Ser Arg Val Cys Gly Tyr Asp Thr Pro Phe Pro 
        355                 360                 365             


His Ile Phe Glu Pro Phe Tyr Ile Pro Asp Lys Trp Lys Cys Tyr Asp 
    370                 375                 380                 


Ala Leu Arg Lys Met Ile Asn Tyr 
385                 390         


<210>  1452
<211>  329
<212>  PRT
<213>  Homo Sapiens

<400>  1452

Met Cys Gly Ala Thr Ser Phe Leu His Glu Cys Thr Arg Leu Ile Leu 
1               5                   10                  15      


Val Thr Thr Gln Asn Ala Glu Phe Leu Gln Lys Gly Leu Gln Val His 
            20                  25                  30          


Thr Cys Phe Gly Val Tyr Pro His Ala Ser Val Trp His Asp Cys Ala 
        35                  40                  45              


Ser Gln Lys Lys Gly Cys Ala Val Tyr Leu His Val Ser Val Glu Phe 
    50                  55                  60                  


Asn Lys Leu Ile Pro Glu Asn Gly Phe Ile Lys Phe His Gln Val Arg 
65                  70                  75                  80  


Arg Val Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly 
                85                  90                  95      


Cys Met Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly 
            100                 105                 110         


Gly Leu Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val 
        115                 120                 125             


Asn Gly Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr 
    130                 135                 140                 


Phe Glu His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg 
145                 150                 155                 160 


Pro Asn Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val 
                165                 170                 175     


Met Leu Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu 
            180                 185                 190         


Glu Glu Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val 
        195                 200                 205             


Arg Arg His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp 
    210                 215                 220                 


Ser Ile Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp 
225                 230                 235                 240 


Met Ser Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys 
                245                 250                 255     


Gly Gln Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly 
            260                 265                 270         


Tyr Thr Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser 
        275                 280                 285             


Gln Cys Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser 
    290                 295                 300                 


Lys Lys Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val 
305                 310                 315                 320 


Cys Thr Leu Thr Ile Lys Arg Gly Arg 
                325                 


<210>  1453
<211>  77
<212>  PRT
<213>  Homo Sapiens

<400>  1453

Met Cys Gly Ala Thr Ser Phe Leu His Glu Cys Thr Arg Leu Ile Leu 
1               5                   10                  15      


Val Thr Thr Gln Asn Ala Glu Phe Leu Gln Lys Gly Leu Gln Val His 
            20                  25                  30          


Thr Cys Phe Gly Val Tyr Pro His Ala Ser Val Trp His Asp Cys Ala 
        35                  40                  45              


Ser Gln Lys Lys Gly Cys Ala Val Tyr Leu His Val Ser Val Glu Phe 
    50                  55                  60                  


Asn Lys Leu Ile Pro Glu Asn Gly Phe Ile Lys Gly Trp 
65                  70                  75          


<210>  1454
<211>  255
<212>  PRT
<213>  Homo Sapiens

<400>  1454

Met Phe His Gln Val Arg Arg Val Met Thr Ile Leu Phe Leu Thr Met 
1               5                   10                  15      


Val Ile Ser Tyr Phe Gly Cys Met Lys Ala Ala Pro Met Lys Glu Ala 
            20                  25                  30          


Asn Ile Arg Gly Gln Gly Gly Leu Ala Tyr Pro Gly Val Arg Thr His 
        35                  40                  45              


Gly Thr Leu Glu Ser Val Asn Gly Pro Lys Ala Gly Ser Arg Gly Leu 
    50                  55                  60                  


Thr Ser Leu Ala Asp Thr Phe Glu His Val Ile Glu Glu Leu Leu Asp 
65                  70                  75                  80  


Glu Asp Gln Lys Val Arg Pro Asn Glu Glu Asn Asn Lys Asp Ala Asp 
                85                  90                  95      


Leu Tyr Thr Ser Arg Val Met Leu Ser Ser Gln Val Pro Leu Glu Pro 
            100                 105                 110         


Pro Leu Leu Phe Leu Leu Glu Glu Tyr Lys Asn Tyr Leu Asp Ala Ala 
        115                 120                 125             


Asn Met Ser Met Arg Val Arg Arg His Ser Asp Pro Ala Arg Arg Gly 
    130                 135                 140                 


Glu Leu Ser Val Cys Asp Ser Ile Ser Glu Trp Val Thr Ala Ala Asp 
145                 150                 155                 160 


Lys Lys Thr Ala Val Asp Met Ser Gly Gly Thr Val Thr Val Leu Glu 
                165                 170                 175     


Lys Val Pro Val Ser Lys Gly Gln Leu Lys Gln Tyr Phe Tyr Glu Thr 
            180                 185                 190         


Lys Cys Asn Pro Met Gly Tyr Thr Lys Glu Gly Cys Arg Gly Ile Asp 
        195                 200                 205             


Lys Arg His Trp Asn Ser Gln Cys Arg Thr Thr Gln Ser Tyr Val Arg 
    210                 215                 220                 


Ala Leu Thr Met Asp Ser Lys Lys Arg Ile Gly Trp Arg Phe Ile Arg 
225                 230                 235                 240 


Ile Asp Thr Ser Cys Val Cys Thr Leu Thr Ile Lys Arg Gly Arg 
                245                 250                 255 


<210>  1455
<211>  262
<212>  PRT
<213>  Homo Sapiens

<400>  1455

Met Gln Ser Arg Glu Glu Glu Trp Phe His Gln Val Arg Arg Val Met 
1               5                   10                  15      


Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met Lys 
            20                  25                  30          


Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu Ala 
        35                  40                  45              


Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly Pro 
    50                  55                  60                  


Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu His 
65                  70                  75                  80  


Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn Glu 
                85                  90                  95      


Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu Ser 
            100                 105                 110         


Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu Tyr 
        115                 120                 125             


Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg His 
    130                 135                 140                 


Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile Ser 
145                 150                 155                 160 


Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser Gly 
                165                 170                 175     


Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln Leu 
            180                 185                 190         


Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr Lys 
        195                 200                 205             


Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys Arg 
    210                 215                 220                 


Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys Arg 
225                 230                 235                 240 


Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr Leu 
                245                 250                 255     


Thr Ile Lys Arg Gly Arg 
            260         


<210>  1456
<211>  247
<212>  PRT
<213>  Homo Sapiens

<400>  1456

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  1457
<211>  247
<212>  PRT
<213>  Homo Sapiens

<400>  1457

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  1458
<211>  247
<212>  PRT
<213>  Homo Sapiens

<400>  1458

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  1459
<211>  247
<212>  PRT
<213>  Homo Sapiens

<400>  1459

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  1460
<211>  247
<212>  PRT
<213>  Homo Sapiens

<400>  1460

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  1461
<211>  247
<212>  PRT
<213>  Homo Sapiens

<400>  1461

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  1462
<211>  247
<212>  PRT
<213>  Homo Sapiens

<400>  1462

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  1463
<211>  247
<212>  PRT
<213>  Homo Sapiens

<400>  1463

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  1464
<211>  247
<212>  PRT
<213>  Homo Sapiens

<400>  1464

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  1465
<211>  247
<212>  PRT
<213>  Homo Sapiens

<400>  1465

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  1466
<211>  247
<212>  PRT
<213>  Homo Sapiens

<400>  1466

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  1467
<211>  247
<212>  PRT
<213>  Homo Sapiens

<400>  1467

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  1468
<211>  247
<212>  PRT
<213>  Homo Sapiens

<400>  1468

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  1469
<211>  247
<212>  PRT
<213>  Homo Sapiens

<400>  1469

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  1470
<211>  100
<212>  PRT
<213>  Homo Sapiens

<400>  1470

Met Arg Ala Leu Thr Leu Leu Ala Leu Leu Ala Leu Ala Ala Leu Cys 
1               5                   10                  15      


Ile Ala Gly Gln Ala Gly Ala Lys Pro Ser Gly Ala Glu Ser Ser Lys 
            20                  25                  30          


Gly Ala Ala Phe Val Ser Lys Gln Glu Gly Ser Glu Val Val Lys Arg 
        35                  40                  45              


Pro Arg Arg Tyr Leu Tyr Gln Trp Leu Gly Ala Pro Val Pro Tyr Pro 
    50                  55                  60                  


Asp Pro Leu Glu Pro Arg Arg Glu Val Cys Glu Leu Asn Pro Asp Cys 
65                  70                  75                  80  


Asp Glu Leu Ala Asp His Ile Gly Phe Gln Glu Ala Tyr Arg Arg Phe 
                85                  90                  95      


Tyr Gly Pro Val 
            100 


<210>  1471
<211>  368
<212>  PRT
<213>  Homo Sapiens

<400>  1471

Met Trp Pro Leu Trp Arg Leu Val Ser Leu Leu Ala Leu Ser Gln Ala 
1               5                   10                  15      


Leu Pro Phe Glu Gln Arg Gly Phe Trp Asp Phe Thr Leu Asp Asp Gly 
            20                  25                  30          


Pro Phe Met Met Asn Asp Glu Glu Ala Ser Gly Ala Asp Thr Ser Gly 
        35                  40                  45              


Val Leu Asp Pro Asp Ser Val Thr Pro Thr Tyr Ser Ala Met Cys Pro 
    50                  55                  60                  


Phe Gly Cys His Cys His Leu Arg Val Val Gln Cys Ser Asp Leu Gly 
65                  70                  75                  80  


Leu Lys Ser Val Pro Lys Glu Ile Ser Pro Asp Thr Thr Leu Leu Asp 
                85                  90                  95      


Leu Gln Asn Asn Asp Ile Ser Glu Leu Arg Lys Asp Asp Phe Lys Gly 
            100                 105                 110         


Leu Gln His Leu Tyr Ala Leu Val Leu Val Asn Asn Lys Ile Ser Lys 
        115                 120                 125             


Ile His Glu Lys Ala Phe Ser Pro Leu Arg Lys Leu Gln Lys Leu Tyr 
    130                 135                 140                 


Ile Ser Lys Asn His Leu Val Glu Ile Pro Pro Asn Leu Pro Ser Ser 
145                 150                 155                 160 


Leu Val Glu Leu Arg Ile His Asp Asn Arg Ile Arg Lys Val Pro Lys 
                165                 170                 175     


Gly Val Phe Ser Gly Leu Arg Asn Met Asn Cys Ile Glu Met Gly Gly 
            180                 185                 190         


Asn Pro Leu Glu Asn Ser Gly Phe Glu Pro Gly Ala Phe Asp Gly Leu 
        195                 200                 205             


Lys Leu Asn Tyr Leu Arg Ile Ser Glu Ala Lys Leu Thr Gly Ile Pro 
    210                 215                 220                 


Lys Asp Leu Pro Glu Thr Leu Asn Glu Leu His Leu Asp His Asn Lys 
225                 230                 235                 240 


Ile Gln Ala Ile Glu Leu Glu Asp Leu Leu Arg Tyr Ser Lys Leu Tyr 
                245                 250                 255     


Arg Leu Gly Leu Gly His Asn Gln Ile Arg Met Ile Glu Asn Gly Ser 
            260                 265                 270         


Leu Ser Phe Leu Pro Thr Leu Arg Glu Leu His Leu Asp Asn Asn Lys 
        275                 280                 285             


Leu Ala Arg Val Pro Ser Gly Leu Pro Asp Leu Lys Leu Leu Gln Val 
    290                 295                 300                 


Val Tyr Leu His Ser Asn Asn Ile Thr Lys Val Gly Val Asn Asp Phe 
305                 310                 315                 320 


Cys Pro Met Gly Phe Gly Val Lys Arg Ala Tyr Tyr Asn Gly Ile Ser 
                325                 330                 335     


Leu Phe Asn Asn Pro Val Pro Tyr Trp Glu Val Gln Pro Ala Thr Phe 
            340                 345                 350         


Arg Cys Val Thr Asp Arg Leu Ala Ile Gln Phe Gly Asn Tyr Lys Lys 
        355                 360                 365             


<210>  1472
<211>  238
<212>  PRT
<213>  Homo Sapiens

<400>  1472

Met Trp Pro Leu Trp Arg Leu Val Ser Leu Leu Ala Leu Ser Gln Ala 
1               5                   10                  15      


Leu Pro Phe Glu Gln Arg Gly Phe Trp Asp Phe Thr Leu Asp Asp Gly 
            20                  25                  30          


Pro Phe Met Met Asn Asp Glu Glu Ala Ser Gly Ala Asp Thr Ser Gly 
        35                  40                  45              


Val Leu Asp Pro Asp Ser Val Thr Pro Thr Tyr Ser Ala Met Cys Pro 
    50                  55                  60                  


Phe Gly Cys His Cys His Leu Arg Val Val Gln Cys Ser Asp Leu Gly 
65                  70                  75                  80  


Leu Lys Ser Val Pro Lys Glu Ile Ser Pro Asp Thr Thr Leu Leu Asp 
                85                  90                  95      


Leu Gln Asn Asn Asp Ile Ser Glu Leu Arg Lys Asp Asp Phe Lys Gly 
            100                 105                 110         


Leu Gln His Leu Tyr Val Arg Ser Trp Glu Glu Pro Ala Gly Leu Gln 
        115                 120                 125             


Gln Arg Ala Gly Val Arg Ala Leu Val Leu Val Asn Asn Lys Ile Ser 
    130                 135                 140                 


Lys Ile His Glu Lys Ala Phe Ser Pro Leu Arg Lys Leu Gln Lys Leu 
145                 150                 155                 160 


Tyr Ile Ser Lys Asn His Leu Val Glu Ile Pro Pro Asn Leu Pro Ser 
                165                 170                 175     


Ser Leu Val Glu Leu Arg Ile His Asp Asn Arg Ile Arg Lys Val Pro 
            180                 185                 190         


Lys Gly Val Phe Ser Gly Leu Arg Asn Met Asn Cys Ile Glu Met Gly 
        195                 200                 205             


Gly Asn Pro Leu Glu Asn Ser Gly Phe Glu Pro Gly Ala Phe Asp Gly 
    210                 215                 220                 


Leu Lys Leu Asn Tyr Leu Arg Ile Ser Glu Ala Lys Leu Thr 
225                 230                 235             


<210>  1473
<211>  121
<212>  PRT
<213>  Homo Sapiens

<400>  1473

Met Ala Val Lys Lys Ile Ala Ile Phe Gly Ala Thr Gly Gln Thr Gly 
1               5                   10                  15      


Leu Thr Thr Leu Ala Gln Ala Val Gln Ala Gly Tyr Glu Val Thr Val 
            20                  25                  30          


Leu Val Arg Asp Ser Ser Arg Leu Pro Ser Glu Gly Pro Arg Pro Ala 
        35                  40                  45              


His Val Val Val Gly Asp Val Leu Gln Ala Ala Asp Val Asp Lys Thr 
    50                  55                  60                  


Val Ala Gly Gln Asp Ala Val Ile Val Leu Leu Gly Thr Arg Asn Asp 
65                  70                  75                  80  


Leu Ser Pro Thr Thr Val Met Ser Glu Gly Ala Arg Asn Ile Val Ala 
                85                  90                  95      


Ala Met Lys Ala His Gly Val Asp Lys Leu Ser Cys Ser Gly Thr Leu 
            100                 105                 110         


Pro Arg Cys Pro His Asp Cys Arg Leu 
        115                 120     


<210>  1474
<211>  206
<212>  PRT
<213>  Homo Sapiens

<400>  1474

Met Ala Val Lys Lys Ile Ala Ile Phe Gly Ala Thr Gly Gln Thr Gly 
1               5                   10                  15      


Leu Thr Thr Leu Ala Gln Ala Val Gln Ala Gly Tyr Glu Val Thr Val 
            20                  25                  30          


Leu Val Arg Asp Ser Ser Arg Leu Pro Ser Glu Gly Pro Arg Pro Ala 
        35                  40                  45              


His Val Val Val Gly Asp Val Leu Gln Ala Ala Asp Val Asp Lys Thr 
    50                  55                  60                  


Val Ala Gly Gln Asp Ala Val Ile Val Leu Leu Gly Thr Arg Asn Asp 
65                  70                  75                  80  


Leu Ser Pro Thr Thr Val Met Ser Glu Gly Ala Arg Asn Ile Val Ala 
                85                  90                  95      


Ala Met Lys Ala His Gly Val Asp Lys Val Val Ala Cys Thr Ser Ala 
            100                 105                 110         


Phe Leu Leu Trp Asp Pro Thr Lys Val Pro Pro Arg Leu Gln Ala Val 
        115                 120                 125             


Thr Asp Asp His Ile Arg Met His Lys Val Leu Arg Glu Ser Gly Leu 
    130                 135                 140                 


Lys Tyr Val Ala Val Met Pro Pro His Ile Gly Asp Gln Pro Leu Thr 
145                 150                 155                 160 


Gly Ala Tyr Thr Val Thr Leu Asp Gly Arg Gly Pro Ser Arg Val Ile 
                165                 170                 175     


Ser Lys His Asp Leu Gly His Phe Met Leu Arg Cys Leu Thr Thr Asp 
            180                 185                 190         


Glu Tyr Asp Gly His Ser Thr Tyr Pro Ser His Gln Tyr Gln 
        195                 200                 205     


<210>  1475
<211>  163
<212>  PRT
<213>  Homo Sapiens

<400>  1475

Met Ala Val Lys Lys Ile Ala Ile Phe Gly Ala Thr Gly Gln Thr Gly 
1               5                   10                  15      


Leu Thr Thr Leu Ala Gln Ala Val Gln Ala Gly Tyr Glu Val Thr Val 
            20                  25                  30          


Leu Val Arg Asp Ser Ser Arg Leu Pro Ser Glu Gly Pro Arg Pro Ala 
        35                  40                  45              


His Val Val Val Gly Asp Val Leu Gln Ala Ala Asp Val Asp Lys Thr 
    50                  55                  60                  


Val Ala Gly Gln Asp Ala Val Ile Val Leu Leu Gly Thr Arg Asn Asp 
65                  70                  75                  80  


Leu Ser Pro Thr Thr Val Met Ser Glu Gly Ala Arg Asn Ile Val Ala 
                85                  90                  95      


Ala Met Lys Ala His Gly Val Asp Lys Val Val Ala Cys Thr Ser Gly 
            100                 105                 110         


Asp Gln Pro Leu Thr Gly Ala Tyr Thr Val Thr Leu Asp Gly Arg Gly 
        115                 120                 125             


Pro Ser Arg Val Ile Ser Lys His Asp Leu Gly His Phe Met Leu Arg 
    130                 135                 140                 


Cys Leu Thr Thr Asp Glu Tyr Asp Gly His Ser Thr Tyr Pro Ser His 
145                 150                 155                 160 


Gln Tyr Gln 
            


<210>  1476
<211>  154
<212>  PRT
<213>  Homo Sapiens

<400>  1476

Met Ala Val Lys Lys Ile Ala Ile Phe Gly Ala Thr Gly Gln Thr Gly 
1               5                   10                  15      


Leu Thr Thr Leu Ala Gln Ala Val Gln Ala Gly Tyr Glu Val Thr Val 
            20                  25                  30          


Leu Val Arg Asp Ser Ser Arg Leu Pro Ser Glu Gly Pro Arg Pro Ala 
        35                  40                  45              


His Val Val Val Gly Asp Val Leu Gln Ala Ala Asp Val Asp Lys Thr 
    50                  55                  60                  


Val Ala Gly Gln Asp Ala Val Ile Val Leu Leu Gly Thr Arg Asn Asp 
65                  70                  75                  80  


Leu Ser Pro Thr Thr Val Met Ser Glu Gly Ala Arg Asn Ile Val Ala 
                85                  90                  95      


Ala Met Lys Ala His Gly Val Asp Lys Val Val Ala Cys Thr Ser Gly 
            100                 105                 110         


Gly Trp Trp Asp His Gly Gly Gly Ala Glu Leu Gly Gly Thr Gly Glu 
        115                 120                 125             


Ala Ala Gln Gly Pro Leu Lys Gly Asp Ala Glu Ala Ile Pro Cys Tyr 
    130                 135                 140                 


Cys Ala Phe Thr Glu His Gln Leu Cys Ala 
145                 150                 


<210>  1477
<211>  245
<212>  PRT
<213>  Homo Sapiens

<400>  1477

Met Ala Val Lys Lys Ile Ala Ile Phe Gly Ala Thr Gly Gln Thr Gly 
1               5                   10                  15      


Leu Thr Thr Leu Ala Gln Ala Val Gln Ala Gly Tyr Glu Val Thr Val 
            20                  25                  30          


Leu Val Arg Asp Ser Ser Arg Leu Pro Ser Glu Gly Pro Arg Pro Ala 
        35                  40                  45              


His Val Val Val Gly Asp Val Leu Gln Ala Ala Asp Val Asp Lys Thr 
    50                  55                  60                  


Val Ala Gly Gln Asp Ala Val Ile Val Leu Leu Gly Thr Arg Asn Asp 
65                  70                  75                  80  


Leu Ser Thr Glu Pro Pro Leu Cys Pro Arg Pro Ser Pro Thr Pro Arg 
                85                  90                  95      


Pro Pro Ala Pro Pro Pro Pro Pro Ala Pro Pro Leu Pro Pro Leu Pro 
            100                 105                 110         


Pro Pro Pro Pro Thr Ser Asp Ser His Ser Leu Ser Pro Leu Arg Ser 
        115                 120                 125             


His Asp Ser Asp Val Arg Gly Arg Pro Glu His Cys Gly Ser His Glu 
    130                 135                 140                 


Gly Ser Trp Cys Gly Gln Ala Phe Leu Leu Trp Asp Pro Thr Lys Val 
145                 150                 155                 160 


Pro Pro Arg Leu Gln Ala Val Thr Asp Asp His Ile Arg Met His Lys 
                165                 170                 175     


Val Leu Arg Glu Ser Gly Leu Lys Tyr Val Ala Val Met Pro Pro His 
            180                 185                 190         


Ile Gly Asp Gln Pro Leu Thr Gly Ala Tyr Thr Val Thr Leu Asp Gly 
        195                 200                 205             


Arg Gly Pro Ser Arg Val Ile Ser Lys His Asp Leu Gly His Phe Met 
    210                 215                 220                 


Leu Arg Cys Leu Thr Thr Asp Glu Tyr Asp Gly His Ser Thr Tyr Pro 
225                 230                 235                 240 


Ser His Gln Tyr Gln 
                245 


<210>  1478
<211>  730
<212>  PRT
<213>  Homo Sapiens

<400>  1478

Met Pro Gly Val Ala Arg Leu Pro Leu Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Arg Pro Gly Arg Pro Leu Asp Leu Ala Asp Tyr Thr Tyr Asp Leu 
            20                  25                  30          


Ala Glu Glu Asp Asp Ser Glu Pro Leu Asn Tyr Lys Asp Pro Cys Lys 
        35                  40                  45              


Ala Ala Ala Phe Leu Gly Asp Ile Ala Leu Asp Glu Glu Asp Leu Arg 
    50                  55                  60                  


Ala Phe Gln Val Gln Gln Ala Val Asp Leu Arg Arg His Thr Ala Arg 
65                  70                  75                  80  


Lys Ser Ser Ile Lys Ala Ala Val Pro Gly Asn Thr Ser Thr Pro Ser 
                85                  90                  95      


Cys Gln Ser Thr Asn Gly Gln Pro Gln Arg Gly Ala Cys Gly Arg Trp 
            100                 105                 110         


Arg Gly Arg Ser Arg Ser Arg Arg Ala Ala Thr Ser Arg Pro Glu Arg 
        115                 120                 125             


Val Trp Pro Asp Gly Val Ile Pro Phe Val Ile Gly Gly Asn Phe Thr 
    130                 135                 140                 


Gly Ser Gln Arg Ala Val Phe Arg Gln Ala Met Arg His Trp Glu Lys 
145                 150                 155                 160 


His Thr Cys Val Thr Phe Leu Glu Arg Thr Asp Glu Asp Ser Tyr Ile 
                165                 170                 175     


Val Phe Thr Tyr Arg Pro Cys Gly Cys Cys Ser Tyr Val Gly Arg Arg 
            180                 185                 190         


Gly Gly Gly Pro Gln Ala Ile Ser Ile Gly Lys Asn Cys Asp Lys Phe 
        195                 200                 205             


Gly Ile Val Val His Glu Leu Gly His Val Val Gly Phe Trp His Glu 
    210                 215                 220                 


His Thr Arg Pro Asp Arg Asp Arg His Val Ser Ile Val Arg Glu Asn 
225                 230                 235                 240 


Ile Gln Pro Gly Gln Glu Tyr Asn Phe Leu Lys Met Glu Pro Gln Glu 
                245                 250                 255     


Val Glu Ser Leu Gly Glu Thr Tyr Asp Phe Asp Ser Ile Met His Tyr 
            260                 265                 270         


Ala Arg Asn Thr Phe Ser Arg Gly Ile Phe Leu Asp Thr Ile Val Pro 
        275                 280                 285             


Lys Tyr Glu Val Asn Gly Val Lys Pro Pro Ile Gly Gln Arg Thr Arg 
    290                 295                 300                 


Leu Ser Lys Gly Asp Ile Ala Gln Ala Arg Lys Leu Tyr Lys Cys Pro 
305                 310                 315                 320 


Ala Cys Gly Glu Thr Leu Gln Asp Ser Thr Gly Asn Phe Ser Ser Pro 
                325                 330                 335     


Glu Tyr Pro Asn Gly Tyr Ser Ala His Met His Cys Val Trp Arg Ile 
            340                 345                 350         


Ser Val Thr Pro Gly Glu Lys Ile Ile Leu Asn Phe Thr Ser Leu Asp 
        355                 360                 365             


Leu Tyr Arg Ser Arg Leu Cys Trp Tyr Asp Tyr Val Glu Val Arg Asp 
    370                 375                 380                 


Gly Phe Trp Arg Lys Ala Pro Leu Arg Gly Arg Phe Cys Gly Ser Lys 
385                 390                 395                 400 


Leu Pro Glu Pro Ile Val Ser Thr Asp Ser Arg Leu Trp Val Glu Phe 
                405                 410                 415     


Arg Ser Ser Ser Asn Trp Val Gly Lys Gly Phe Phe Ala Val Tyr Glu 
            420                 425                 430         


Ala Ile Cys Gly Gly Asp Val Lys Lys Asp Tyr Gly His Ile Gln Ser 
        435                 440                 445             


Pro Asn Tyr Pro Asp Asp Tyr Arg Pro Ser Lys Val Cys Ile Trp Arg 
    450                 455                 460                 


Ile Gln Val Ser Glu Gly Phe His Val Gly Leu Thr Phe Gln Ser Phe 
465                 470                 475                 480 


Glu Ile Glu Arg His Asp Ser Cys Ala Tyr Asp Tyr Leu Glu Val Arg 
                485                 490                 495     


Asp Gly His Ser Glu Ser Ser Thr Leu Ile Gly Arg Tyr Cys Gly Tyr 
            500                 505                 510         


Glu Lys Pro Asp Asp Ile Lys Ser Thr Ser Ser Arg Leu Trp Leu Lys 
        515                 520                 525             


Phe Val Ser Asp Gly Ser Ile Asn Lys Ala Gly Phe Ala Val Asn Phe 
    530                 535                 540                 


Phe Lys Glu Val Asp Glu Cys Ser Arg Pro Asn Arg Gly Gly Cys Glu 
545                 550                 555                 560 


Gln Arg Cys Leu Asn Thr Leu Gly Ser Tyr Lys Cys Ser Cys Asp Pro 
                565                 570                 575     


Gly Tyr Glu Leu Ala Pro Asp Lys Arg Arg Cys Glu Ala Ala Cys Gly 
            580                 585                 590         


Gly Phe Leu Thr Lys Leu Asn Gly Ser Ile Thr Ser Pro Gly Trp Pro 
        595                 600                 605             


Lys Glu Tyr Pro Pro Asn Lys Asn Cys Ile Trp Gln Leu Val Ala Pro 
    610                 615                 620                 


Thr Gln Tyr Arg Ile Ser Leu Gln Phe Asp Phe Phe Glu Thr Glu Gly 
625                 630                 635                 640 


Asn Asp Val Cys Lys Tyr Asp Phe Val Glu Val Arg Ser Gly Leu Thr 
                645                 650                 655     


Ala Asp Ser Lys Leu His Gly Lys Phe Cys Gly Ser Glu Lys Pro Glu 
            660                 665                 670         


Val Ile Thr Ser Gln Tyr Asn Asn Met Arg Val Glu Phe Lys Ser Asp 
        675                 680                 685             


Asn Thr Val Ser Lys Lys Gly Phe Lys Ala His Phe Phe Ser Glu Lys 
    690                 695                 700                 


Arg Pro Ala Leu Gln Pro Pro Arg Gly Arg Pro His Gln Leu Lys Phe 
705                 710                 715                 720 


Arg Val Gln Lys Arg Asn Arg Thr Pro Gln 
                725                 730 


<210>  1479
<211>  986
<212>  PRT
<213>  Homo Sapiens

<400>  1479

Met Pro Gly Val Ala Arg Leu Pro Leu Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Arg Pro Gly Arg Pro Leu Asp Leu Ala Asp Tyr Thr Tyr Asp Leu 
            20                  25                  30          


Ala Glu Glu Asp Asp Ser Glu Pro Leu Asn Tyr Lys Asp Pro Cys Lys 
        35                  40                  45              


Ala Ala Ala Phe Leu Gly Asp Ile Ala Leu Asp Glu Glu Asp Leu Arg 
    50                  55                  60                  


Ala Phe Gln Val Gln Gln Ala Val Asp Leu Arg Arg His Thr Ala Arg 
65                  70                  75                  80  


Lys Ser Ser Ile Lys Ala Ala Val Pro Gly Asn Thr Ser Thr Pro Ser 
                85                  90                  95      


Cys Gln Ser Thr Asn Gly Gln Pro Gln Arg Gly Ala Cys Gly Arg Trp 
            100                 105                 110         


Arg Gly Arg Ser Arg Ser Arg Arg Ala Ala Thr Ser Arg Pro Glu Arg 
        115                 120                 125             


Val Trp Pro Asp Gly Val Ile Pro Phe Val Ile Gly Gly Asn Phe Thr 
    130                 135                 140                 


Gly Ser Gln Arg Ala Val Phe Arg Gln Ala Met Arg His Trp Glu Lys 
145                 150                 155                 160 


His Thr Cys Val Thr Phe Leu Glu Arg Thr Asp Glu Asp Ser Tyr Ile 
                165                 170                 175     


Val Phe Thr Tyr Arg Pro Cys Gly Cys Cys Ser Tyr Val Gly Arg Arg 
            180                 185                 190         


Gly Gly Gly Pro Gln Ala Ile Ser Ile Gly Lys Asn Cys Asp Lys Phe 
        195                 200                 205             


Gly Ile Val Val His Glu Leu Gly His Val Val Gly Phe Trp His Glu 
    210                 215                 220                 


His Thr Arg Pro Asp Arg Asp Arg His Val Ser Ile Val Arg Glu Asn 
225                 230                 235                 240 


Ile Gln Pro Gly Gln Glu Tyr Asn Phe Leu Lys Met Glu Pro Gln Glu 
                245                 250                 255     


Val Glu Ser Leu Gly Glu Thr Tyr Asp Phe Asp Ser Ile Met His Tyr 
            260                 265                 270         


Ala Arg Asn Thr Phe Ser Arg Gly Ile Phe Leu Asp Thr Ile Val Pro 
        275                 280                 285             


Lys Tyr Glu Val Asn Gly Val Lys Pro Pro Ile Gly Gln Arg Thr Arg 
    290                 295                 300                 


Leu Ser Lys Gly Asp Ile Ala Gln Ala Arg Lys Leu Tyr Lys Cys Pro 
305                 310                 315                 320 


Ala Cys Gly Glu Thr Leu Gln Asp Ser Thr Gly Asn Phe Ser Ser Pro 
                325                 330                 335     


Glu Tyr Pro Asn Gly Tyr Ser Ala His Met His Cys Val Trp Arg Ile 
            340                 345                 350         


Ser Val Thr Pro Gly Glu Lys Ile Ile Leu Asn Phe Thr Ser Leu Asp 
        355                 360                 365             


Leu Tyr Arg Ser Arg Leu Cys Trp Tyr Asp Tyr Val Glu Val Arg Asp 
    370                 375                 380                 


Gly Phe Trp Arg Lys Ala Pro Leu Arg Gly Arg Phe Cys Gly Ser Lys 
385                 390                 395                 400 


Leu Pro Glu Pro Ile Val Ser Thr Asp Ser Arg Leu Trp Val Glu Phe 
                405                 410                 415     


Arg Ser Ser Ser Asn Trp Val Gly Lys Gly Phe Phe Ala Val Tyr Glu 
            420                 425                 430         


Ala Ile Cys Gly Gly Asp Val Lys Lys Asp Tyr Gly His Ile Gln Ser 
        435                 440                 445             


Pro Asn Tyr Pro Asp Asp Tyr Arg Pro Ser Lys Val Cys Ile Trp Arg 
    450                 455                 460                 


Ile Gln Val Ser Glu Gly Phe His Val Gly Leu Thr Phe Gln Ser Phe 
465                 470                 475                 480 


Glu Ile Glu Arg His Asp Ser Cys Ala Tyr Asp Tyr Leu Glu Val Arg 
                485                 490                 495     


Asp Gly His Ser Glu Ser Ser Thr Leu Ile Gly Arg Tyr Cys Gly Tyr 
            500                 505                 510         


Glu Lys Pro Asp Asp Ile Lys Ser Thr Ser Ser Arg Leu Trp Leu Lys 
        515                 520                 525             


Phe Val Ser Asp Gly Ser Ile Asn Lys Ala Gly Phe Ala Val Asn Phe 
    530                 535                 540                 


Phe Lys Glu Val Asp Glu Cys Ser Arg Pro Asn Arg Gly Gly Cys Glu 
545                 550                 555                 560 


Gln Arg Cys Leu Asn Thr Leu Gly Ser Tyr Lys Cys Ser Cys Asp Pro 
                565                 570                 575     


Gly Tyr Glu Leu Ala Pro Asp Lys Arg Arg Cys Glu Ala Ala Cys Gly 
            580                 585                 590         


Gly Phe Leu Thr Lys Leu Asn Gly Ser Ile Thr Ser Pro Gly Trp Pro 
        595                 600                 605             


Lys Glu Tyr Pro Pro Asn Lys Asn Cys Ile Trp Gln Leu Val Ala Pro 
    610                 615                 620                 


Thr Gln Tyr Arg Ile Ser Leu Gln Phe Asp Phe Phe Glu Thr Glu Gly 
625                 630                 635                 640 


Asn Asp Val Cys Lys Tyr Asp Phe Val Glu Val Arg Ser Gly Leu Thr 
                645                 650                 655     


Ala Asp Ser Lys Leu His Gly Lys Phe Cys Gly Ser Glu Lys Pro Glu 
            660                 665                 670         


Val Ile Thr Ser Gln Tyr Asn Asn Met Arg Val Glu Phe Lys Ser Asp 
        675                 680                 685             


Asn Thr Val Ser Lys Lys Gly Phe Lys Ala His Phe Phe Ser Asp Lys 
    690                 695                 700                 


Asp Glu Cys Ser Lys Asp Asn Gly Gly Cys Gln Gln Asp Cys Val Asn 
705                 710                 715                 720 


Thr Phe Gly Ser Tyr Glu Cys Gln Cys Arg Ser Gly Phe Val Leu His 
                725                 730                 735     


Asp Asn Lys His Asp Cys Lys Glu Ala Gly Cys Asp His Lys Val Thr 
            740                 745                 750         


Ser Thr Ser Gly Thr Ile Thr Ser Pro Asn Trp Pro Asp Lys Tyr Pro 
        755                 760                 765             


Ser Lys Lys Glu Cys Thr Trp Ala Ile Ser Ser Thr Pro Gly His Arg 
    770                 775                 780                 


Val Lys Leu Thr Phe Met Glu Met Asp Ile Glu Ser Gln Pro Glu Cys 
785                 790                 795                 800 


Ala Tyr Asp His Leu Glu Val Phe Asp Gly Arg Asp Ala Lys Ala Pro 
                805                 810                 815     


Val Leu Gly Arg Phe Cys Gly Ser Lys Lys Pro Glu Pro Val Leu Ala 
            820                 825                 830         


Thr Gly Ser Arg Met Phe Leu Arg Phe Tyr Ser Asp Asn Ser Val Gln 
        835                 840                 845             


Arg Lys Gly Phe Gln Ala Ser His Ala Thr Glu Cys Gly Gly Gln Val 
    850                 855                 860                 


Arg Ala Asp Val Lys Thr Lys Asp Leu Tyr Ser His Ala Gln Phe Gly 
865                 870                 875                 880 


Asp Asn Asn Tyr Pro Gly Gly Val Asp Cys Glu Trp Val Ile Val Ala 
                885                 890                 895     


Glu Glu Gly Tyr Gly Val Glu Leu Val Phe Gln Thr Phe Glu Val Glu 
            900                 905                 910         


Glu Glu Thr Asp Cys Gly Tyr Asp Tyr Met Glu Leu Phe Asp Gly Tyr 
        915                 920                 925             


Asp Ser Thr Ala Pro Arg Leu Gly Arg Tyr Cys Gly Ser Gly Pro Pro 
    930                 935                 940                 


Glu Glu Val Tyr Ser Ala Gly Asp Ser Val Leu Val Lys Phe His Ser 
945                 950                 955                 960 


Asp Asp Thr Ile Thr Lys Lys Gly Phe His Leu Arg Tyr Thr Ser Thr 
                965                 970                 975     


Lys Phe Gln Asp Thr Leu His Ser Arg Lys 
            980                 985     


<210>  1480
<211>  622
<212>  PRT
<213>  Homo Sapiens

<400>  1480

Met Pro Gly Val Ala Arg Leu Pro Leu Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Arg Pro Gly Arg Pro Leu Asp Leu Ala Asp Tyr Thr Tyr Asp Leu 
            20                  25                  30          


Ala Glu Glu Asp Asp Ser Glu Pro Leu Asn Tyr Lys Asp Pro Cys Lys 
        35                  40                  45              


Ala Ala Ala Phe Leu Gly Asp Ile Ala Leu Asp Glu Glu Asp Leu Arg 
    50                  55                  60                  


Ala Phe Gln Val Gln Gln Ala Val Asp Leu Arg Arg His Thr Ala Arg 
65                  70                  75                  80  


Lys Ser Ser Ile Lys Ala Ala Val Pro Gly Asn Thr Ser Thr Pro Ser 
                85                  90                  95      


Cys Gln Ser Thr Asn Gly Gln Pro Gln Arg Gly Ala Cys Gly Arg Trp 
            100                 105                 110         


Arg Gly Arg Ser Arg Ser Arg Arg Ala Ala Thr Ser Arg Pro Glu Arg 
        115                 120                 125             


Val Trp Pro Asp Gly Val Ile Pro Phe Val Ile Gly Gly Asn Phe Thr 
    130                 135                 140                 


Gly Ser Gln Arg Ala Val Phe Arg Gln Ala Met Arg His Trp Glu Lys 
145                 150                 155                 160 


His Thr Cys Val Thr Phe Leu Glu Arg Thr Asp Glu Asp Ser Tyr Ile 
                165                 170                 175     


Val Phe Thr Tyr Arg Pro Cys Gly Cys Cys Ser Tyr Val Gly Arg Arg 
            180                 185                 190         


Gly Gly Gly Pro Gln Ala Ile Ser Ile Gly Lys Asn Cys Asp Lys Phe 
        195                 200                 205             


Gly Ile Val Val His Glu Leu Gly His Val Val Gly Phe Trp His Glu 
    210                 215                 220                 


His Thr Arg Pro Asp Arg Asp Arg His Val Ser Ile Val Arg Glu Asn 
225                 230                 235                 240 


Ile Gln Pro Gly Gln Glu Tyr Asn Phe Leu Lys Met Glu Pro Gln Glu 
                245                 250                 255     


Val Glu Ser Leu Gly Glu Thr Tyr Asp Phe Asp Ser Ile Met His Tyr 
            260                 265                 270         


Ala Arg Asn Thr Phe Ser Arg Gly Ile Phe Leu Asp Thr Ile Val Pro 
        275                 280                 285             


Lys Tyr Glu Val Asn Gly Val Lys Pro Pro Ile Gly Gln Arg Thr Arg 
    290                 295                 300                 


Leu Ser Lys Gly Asp Ile Ala Gln Ala Arg Lys Leu Tyr Lys Cys Pro 
305                 310                 315                 320 


Ala Cys Gly Glu Thr Leu Gln Asp Ser Thr Gly Asn Phe Ser Ser Pro 
                325                 330                 335     


Glu Tyr Pro Asn Gly Tyr Ser Ala His Met His Cys Val Trp Arg Ile 
            340                 345                 350         


Ser Val Thr Pro Gly Glu Lys Ile Ile Leu Asn Phe Thr Ser Leu Asp 
        355                 360                 365             


Leu Tyr Arg Ser Arg Leu Cys Trp Tyr Asp Tyr Val Glu Val Arg Asp 
    370                 375                 380                 


Gly Phe Trp Arg Lys Ala Pro Leu Arg Gly Arg Phe Cys Gly Ser Lys 
385                 390                 395                 400 


Leu Pro Glu Pro Ile Val Ser Thr Asp Ser Arg Leu Trp Val Glu Phe 
                405                 410                 415     


Arg Ser Ser Ser Asn Trp Val Gly Lys Gly Phe Phe Ala Val Tyr Glu 
            420                 425                 430         


Ala Ile Cys Gly Gly Asp Val Lys Lys Asp Tyr Gly His Ile Gln Ser 
        435                 440                 445             


Pro Asn Tyr Pro Asp Asp Tyr Arg Pro Ser Lys Val Cys Ile Trp Arg 
    450                 455                 460                 


Ile Gln Val Ser Glu Gly Phe His Val Gly Leu Thr Phe Gln Ser Phe 
465                 470                 475                 480 


Glu Ile Glu Arg His Asp Ser Cys Ala Tyr Asp Tyr Leu Glu Val Arg 
                485                 490                 495     


Asp Gly His Ser Glu Ser Ser Thr Leu Ile Gly Arg Tyr Cys Gly Tyr 
            500                 505                 510         


Glu Lys Pro Asp Asp Ile Lys Ser Thr Ser Ser Arg Leu Trp Leu Lys 
        515                 520                 525             


Phe Val Ser Asp Gly Ser Ile Asn Lys Ala Gly Phe Ala Val Asn Phe 
    530                 535                 540                 


Phe Lys Glu Val Asp Glu Cys Ser Arg Pro Asn Arg Gly Gly Cys Glu 
545                 550                 555                 560 


Gln Arg Cys Leu Asn Thr Leu Gly Ser Tyr Lys Cys Ser Cys Asp Pro 
                565                 570                 575     


Gly Tyr Glu Leu Ala Pro Asp Lys Arg Arg Cys Glu Gly Cys Tyr Asp 
            580                 585                 590         


Leu Gln Val Gly Lys Pro Leu Leu Trp Asp Arg His Cys Phe Arg Leu 
        595                 600                 605             


Ser Thr His Gly Pro Glu Met Leu Gly Thr Ala Leu Arg Gly 
    610                 615                 620         


<210>  1481
<211>  717
<212>  PRT
<213>  Homo Sapiens

<400>  1481

Met Pro Gly Val Ala Arg Leu Pro Leu Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Arg Pro Gly Arg Pro Leu Asp Leu Ala Asp Tyr Thr Tyr Asp Leu 
            20                  25                  30          


Ala Glu Glu Asp Asp Ser Glu Pro Leu Asn Tyr Lys Asp Pro Cys Lys 
        35                  40                  45              


Ala Ala Ala Phe Leu Gly Asp Ile Ala Leu Asp Glu Glu Asp Leu Arg 
    50                  55                  60                  


Ala Phe Gln Val Gln Gln Ala Val Asp Leu Arg Arg His Thr Ala Arg 
65                  70                  75                  80  


Lys Ser Ser Ile Lys Ala Ala Val Pro Gly Asn Thr Ser Thr Pro Ser 
                85                  90                  95      


Cys Gln Ser Thr Asn Gly Gln Pro Gln Arg Gly Ala Cys Gly Arg Trp 
            100                 105                 110         


Arg Gly Arg Ser Arg Ser Arg Arg Ala Ala Thr Ser Arg Pro Glu Arg 
        115                 120                 125             


Val Trp Pro Asp Gly Val Ile Pro Phe Val Ile Gly Gly Asn Phe Thr 
    130                 135                 140                 


Gly Ser Gln Arg Ala Val Phe Arg Gln Ala Met Arg His Trp Glu Lys 
145                 150                 155                 160 


His Thr Cys Val Thr Phe Leu Glu Arg Thr Asp Glu Asp Ser Tyr Ile 
                165                 170                 175     


Val Phe Thr Tyr Arg Pro Cys Gly Cys Cys Ser Tyr Val Gly Arg Arg 
            180                 185                 190         


Gly Gly Gly Pro Gln Ala Ile Ser Ile Gly Lys Asn Cys Asp Lys Phe 
        195                 200                 205             


Gly Ile Val Val His Glu Leu Gly His Val Val Gly Phe Trp His Glu 
    210                 215                 220                 


His Thr Arg Pro Asp Arg Asp Arg His Val Ser Ile Val Arg Glu Asn 
225                 230                 235                 240 


Ile Gln Pro Gly Gln Glu Tyr Asn Phe Leu Lys Met Glu Pro Gln Glu 
                245                 250                 255     


Val Glu Ser Leu Gly Glu Thr Tyr Asp Phe Asp Ser Ile Met His Tyr 
            260                 265                 270         


Ala Arg Asn Thr Phe Ser Arg Gly Ile Phe Leu Asp Thr Ile Val Pro 
        275                 280                 285             


Lys Tyr Glu Val Asn Gly Val Lys Pro Pro Ile Gly Gln Arg Thr Arg 
    290                 295                 300                 


Leu Ser Lys Gly Asp Ile Ala Gln Ala Arg Lys Leu Tyr Lys Cys Pro 
305                 310                 315                 320 


Ala Cys Gly Glu Thr Leu Gln Asp Ser Thr Gly Asn Phe Ser Ser Pro 
                325                 330                 335     


Glu Tyr Pro Asn Gly Tyr Ser Ala His Met His Cys Val Trp Arg Ile 
            340                 345                 350         


Ser Val Thr Pro Gly Glu Lys Ile Ile Leu Asn Phe Thr Ser Leu Asp 
        355                 360                 365             


Leu Tyr Arg Ser Arg Leu Cys Trp Tyr Asp Tyr Val Glu Val Arg Asp 
    370                 375                 380                 


Gly Phe Trp Arg Lys Ala Pro Leu Arg Gly Arg Phe Cys Gly Ser Lys 
385                 390                 395                 400 


Leu Pro Glu Pro Ile Val Ser Thr Asp Ser Arg Leu Trp Val Glu Phe 
                405                 410                 415     


Arg Ser Ser Ser Asn Trp Val Gly Lys Gly Phe Phe Ala Val Tyr Glu 
            420                 425                 430         


Ala Ile Cys Gly Gly Asp Val Lys Lys Asp Tyr Gly His Ile Gln Ser 
        435                 440                 445             


Pro Asn Tyr Pro Asp Asp Tyr Arg Pro Ser Lys Val Cys Ile Trp Arg 
    450                 455                 460                 


Ile Gln Val Ser Glu Gly Phe His Val Gly Leu Thr Phe Gln Ser Phe 
465                 470                 475                 480 


Glu Ile Glu Arg His Asp Ser Cys Ala Tyr Asp Tyr Leu Glu Val Arg 
                485                 490                 495     


Asp Gly His Ser Glu Ser Ser Thr Leu Ile Gly Arg Tyr Cys Gly Tyr 
            500                 505                 510         


Glu Lys Pro Asp Asp Ile Lys Ser Thr Ser Ser Arg Leu Trp Leu Lys 
        515                 520                 525             


Phe Val Ser Asp Gly Ser Ile Asn Lys Ala Gly Phe Ala Val Asn Phe 
    530                 535                 540                 


Phe Lys Glu Val Asp Glu Cys Ser Arg Pro Asn Arg Gly Gly Cys Glu 
545                 550                 555                 560 


Gln Arg Cys Leu Asn Thr Leu Gly Ser Tyr Lys Cys Ser Cys Asp Pro 
                565                 570                 575     


Gly Tyr Glu Leu Ala Pro Asp Lys Arg Arg Cys Glu Ala Ala Cys Gly 
            580                 585                 590         


Gly Phe Leu Thr Lys Leu Asn Gly Ser Ile Thr Ser Pro Gly Trp Pro 
        595                 600                 605             


Lys Glu Tyr Pro Pro Asn Lys Asn Cys Ile Trp Gln Leu Val Ala Pro 
    610                 615                 620                 


Thr Gln Tyr Arg Ile Ser Leu Gln Phe Asp Phe Phe Glu Thr Glu Gly 
625                 630                 635                 640 


Asn Asp Val Cys Lys Tyr Asp Phe Val Glu Val Arg Ser Gly Leu Thr 
                645                 650                 655     


Ala Asp Ser Lys Leu His Gly Lys Phe Cys Gly Ser Glu Lys Pro Glu 
            660                 665                 670         


Val Ile Thr Ser Gln Tyr Asn Asn Met Arg Val Glu Phe Lys Ser Asp 
        675                 680                 685             


Asn Thr Val Ser Lys Lys Gly Phe Lys Ala His Phe Phe Ser Gly Gly 
    690                 695                 700                 


Glu Leu Phe Gly Leu Leu Gly His Pro Pro Arg Arg Pro 
705                 710                 715         


<210>  1482
<211>  730
<212>  PRT
<213>  Homo Sapiens

<400>  1482

Met Pro Gly Val Ala Arg Leu Pro Leu Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Arg Pro Gly Arg Pro Leu Asp Leu Ala Asp Tyr Thr Tyr Asp Leu 
            20                  25                  30          


Ala Glu Glu Asp Asp Ser Glu Pro Leu Asn Tyr Lys Asp Pro Cys Lys 
        35                  40                  45              


Ala Ala Ala Phe Leu Gly Asp Ile Ala Leu Asp Glu Glu Asp Leu Arg 
    50                  55                  60                  


Ala Phe Gln Val Gln Gln Ala Val Asp Leu Arg Arg His Thr Ala Arg 
65                  70                  75                  80  


Lys Ser Ser Ile Lys Ala Ala Val Pro Gly Asn Thr Ser Thr Pro Ser 
                85                  90                  95      


Cys Gln Ser Thr Asn Gly Gln Pro Gln Arg Gly Ala Cys Gly Arg Trp 
            100                 105                 110         


Arg Gly Arg Ser Arg Ser Arg Arg Ala Ala Thr Ser Arg Pro Glu Arg 
        115                 120                 125             


Val Trp Pro Asp Gly Val Ile Pro Phe Val Ile Gly Gly Asn Phe Thr 
    130                 135                 140                 


Gly Ser Gln Arg Ala Val Phe Arg Gln Ala Met Arg His Trp Glu Lys 
145                 150                 155                 160 


His Thr Cys Val Thr Phe Leu Glu Arg Thr Asp Glu Asp Ser Tyr Ile 
                165                 170                 175     


Val Phe Thr Tyr Arg Pro Cys Gly Cys Cys Ser Tyr Val Gly Arg Arg 
            180                 185                 190         


Gly Gly Gly Pro Gln Ala Ile Ser Ile Gly Lys Asn Cys Asp Lys Phe 
        195                 200                 205             


Gly Ile Val Val His Glu Leu Gly His Val Val Gly Phe Trp His Glu 
    210                 215                 220                 


His Thr Arg Pro Asp Arg Asp Arg His Val Ser Ile Val Arg Glu Asn 
225                 230                 235                 240 


Ile Gln Pro Gly Gln Glu Tyr Asn Phe Leu Lys Met Glu Pro Gln Glu 
                245                 250                 255     


Val Glu Ser Leu Gly Glu Thr Tyr Asp Phe Asp Ser Ile Met His Tyr 
            260                 265                 270         


Ala Arg Asn Thr Phe Ser Arg Gly Ile Phe Leu Asp Thr Ile Val Pro 
        275                 280                 285             


Lys Tyr Glu Val Asn Gly Val Lys Pro Pro Ile Gly Gln Arg Thr Arg 
    290                 295                 300                 


Leu Ser Lys Gly Asp Ile Ala Gln Ala Arg Lys Leu Tyr Lys Cys Pro 
305                 310                 315                 320 


Ala Cys Gly Glu Thr Leu Gln Asp Ser Thr Gly Asn Phe Ser Ser Pro 
                325                 330                 335     


Glu Tyr Pro Asn Gly Tyr Ser Ala His Met His Cys Val Trp Arg Ile 
            340                 345                 350         


Ser Val Thr Pro Gly Glu Lys Ile Ile Leu Asn Phe Thr Ser Leu Asp 
        355                 360                 365             


Leu Tyr Arg Ser Arg Leu Cys Trp Tyr Asp Tyr Val Glu Val Arg Asp 
    370                 375                 380                 


Gly Phe Trp Arg Lys Ala Pro Leu Arg Gly Arg Phe Cys Gly Ser Lys 
385                 390                 395                 400 


Leu Pro Glu Pro Ile Val Ser Thr Asp Ser Arg Leu Trp Val Glu Phe 
                405                 410                 415     


Arg Ser Ser Ser Asn Trp Val Gly Lys Gly Phe Phe Ala Val Tyr Glu 
            420                 425                 430         


Ala Ile Cys Gly Gly Asp Val Lys Lys Asp Tyr Gly His Ile Gln Ser 
        435                 440                 445             


Pro Asn Tyr Pro Asp Asp Tyr Arg Pro Ser Lys Val Cys Ile Trp Arg 
    450                 455                 460                 


Ile Gln Val Ser Glu Gly Phe His Val Gly Leu Thr Phe Gln Ser Phe 
465                 470                 475                 480 


Glu Ile Glu Arg His Asp Ser Cys Ala Tyr Asp Tyr Leu Glu Val Arg 
                485                 490                 495     


Asp Gly His Ser Glu Ser Ser Thr Leu Ile Gly Arg Tyr Cys Gly Tyr 
            500                 505                 510         


Glu Lys Pro Asp Asp Ile Lys Ser Thr Ser Ser Arg Leu Trp Leu Lys 
        515                 520                 525             


Phe Val Ser Asp Gly Ser Ile Asn Lys Ala Gly Phe Ala Val Asn Phe 
    530                 535                 540                 


Phe Lys Glu Val Asp Glu Cys Ser Arg Pro Asn Arg Gly Gly Cys Glu 
545                 550                 555                 560 


Gln Arg Cys Leu Asn Thr Leu Gly Ser Tyr Lys Cys Ser Cys Asp Pro 
                565                 570                 575     


Gly Tyr Glu Leu Ala Pro Asp Lys Arg Arg Cys Glu Ala Ala Cys Gly 
            580                 585                 590         


Gly Phe Leu Thr Lys Leu Asn Gly Ser Ile Thr Ser Pro Gly Trp Pro 
        595                 600                 605             


Lys Glu Tyr Pro Pro Asn Lys Asn Cys Ile Trp Gln Leu Val Ala Pro 
    610                 615                 620                 


Thr Gln Tyr Arg Ile Ser Leu Gln Phe Asp Phe Phe Glu Thr Glu Gly 
625                 630                 635                 640 


Asn Asp Val Cys Lys Tyr Asp Phe Val Glu Val Arg Ser Gly Leu Thr 
                645                 650                 655     


Ala Asp Ser Lys Leu His Gly Lys Phe Cys Gly Ser Glu Lys Pro Glu 
            660                 665                 670         


Val Ile Thr Ser Gln Tyr Asn Asn Met Arg Val Glu Phe Lys Ser Asp 
        675                 680                 685             


Asn Thr Val Ser Lys Lys Gly Phe Lys Ala His Phe Phe Ser Glu Lys 
    690                 695                 700                 


Arg Pro Ala Leu Gln Pro Pro Arg Gly Arg Pro His Gln Leu Lys Phe 
705                 710                 715                 720 


Arg Val Gln Lys Arg Asn Arg Thr Pro Gln 
                725                 730 


<210>  1483
<211>  302
<212>  PRT
<213>  Homo Sapiens

<400>  1483

Met Pro Gly Val Ala Arg Leu Pro Leu Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Arg Pro Gly Arg Pro Leu Asp Leu Ala Asp Tyr Thr Tyr Asp Leu 
            20                  25                  30          


Ala Glu Glu Asp Asp Ser Glu Pro Leu Asn Tyr Lys Asp Pro Cys Lys 
        35                  40                  45              


Ala Ala Ala Phe Leu Gly Asp Ile Ala Leu Asp Glu Glu Asp Leu Arg 
    50                  55                  60                  


Ala Phe Gln Val Gln Gln Ala Val Asp Leu Arg Arg His Thr Ala Arg 
65                  70                  75                  80  


Lys Ser Ser Ile Lys Ala Ala Val Pro Gly Asn Thr Ser Thr Pro Ser 
                85                  90                  95      


Cys Gln Ser Thr Asn Gly Gln Pro Gln Arg Gly Ala Cys Gly Arg Trp 
            100                 105                 110         


Arg Gly Arg Ser Arg Ser Arg Arg Ala Ala Thr Ser Arg Pro Glu Arg 
        115                 120                 125             


Val Trp Pro Asp Gly Val Ile Pro Phe Val Ile Gly Gly Asn Phe Thr 
    130                 135                 140                 


Gly Ser Gln Arg Ala Val Phe Arg Gln Ala Met Arg His Trp Glu Lys 
145                 150                 155                 160 


His Thr Cys Val Thr Phe Leu Glu Arg Thr Asp Glu Asp Ser Tyr Ile 
                165                 170                 175     


Val Phe Thr Tyr Arg Pro Cys Gly Cys Cys Ser Tyr Val Gly Arg Arg 
            180                 185                 190         


Gly Gly Gly Pro Gln Ala Ile Ser Ile Gly Lys Asn Cys Asp Lys Phe 
        195                 200                 205             


Gly Ile Val Val His Glu Leu Gly His Val Val Gly Phe Trp His Glu 
    210                 215                 220                 


His Thr Arg Pro Asp Arg Asp Arg His Val Ser Ile Val Arg Glu Asn 
225                 230                 235                 240 


Ile Gln Pro Gly Val Leu His Ser Ser Leu Leu Leu Leu Ser Cys Gly 
                245                 250                 255     


Ser Arg Asn Gly Ala Ser Phe Pro Cys Ser Leu Glu Ser Ser Ile His 
            260                 265                 270         


Gln Ala Leu Cys Trp Thr Gly Leu Phe Leu Arg Pro Ser Pro Phe Pro 
        275                 280                 285             


Arg Leu Pro Leu Ala Ala Pro Arg Thr Leu Arg Ala Gly Val 
    290                 295                 300         


<210>  1484
<211>  302
<212>  PRT
<213>  Homo Sapiens

<400>  1484

Met Pro Gly Val Ala Arg Leu Pro Leu Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Arg Pro Gly Arg Pro Leu Asp Leu Ala Asp Tyr Thr Tyr Asp Leu 
            20                  25                  30          


Ala Glu Glu Asp Asp Ser Glu Pro Leu Asn Tyr Lys Asp Pro Cys Lys 
        35                  40                  45              


Ala Ala Ala Phe Leu Gly Asp Ile Ala Leu Asp Glu Glu Asp Leu Arg 
    50                  55                  60                  


Ala Phe Gln Val Gln Gln Ala Val Asp Leu Arg Arg His Thr Ala Arg 
65                  70                  75                  80  


Lys Ser Ser Ile Lys Ala Ala Val Pro Gly Asn Thr Ser Thr Pro Ser 
                85                  90                  95      


Cys Gln Ser Thr Asn Gly Gln Pro Gln Arg Gly Ala Cys Gly Arg Trp 
            100                 105                 110         


Arg Gly Arg Ser Arg Ser Arg Arg Ala Ala Thr Ser Arg Pro Glu Arg 
        115                 120                 125             


Val Trp Pro Asp Gly Val Ile Pro Phe Val Ile Gly Gly Asn Phe Thr 
    130                 135                 140                 


Gly Ser Gln Arg Ala Val Phe Arg Gln Ala Met Arg His Trp Glu Lys 
145                 150                 155                 160 


His Thr Cys Val Thr Phe Leu Glu Arg Thr Asp Glu Asp Ser Tyr Ile 
                165                 170                 175     


Val Phe Thr Tyr Arg Pro Cys Gly Cys Cys Ser Tyr Val Gly Arg Arg 
            180                 185                 190         


Gly Gly Gly Pro Gln Ala Ile Ser Ile Gly Lys Asn Cys Asp Lys Phe 
        195                 200                 205             


Gly Ile Val Val His Glu Leu Gly His Val Val Gly Phe Trp His Glu 
    210                 215                 220                 


His Thr Arg Pro Asp Arg Asp Arg His Val Ser Ile Val Arg Glu Asn 
225                 230                 235                 240 


Ile Gln Pro Gly Val Leu His Ser Ser Leu Leu Leu Leu Ser Cys Gly 
                245                 250                 255     


Ser Arg Asn Gly Ala Ser Phe Pro Cys Ser Leu Glu Ser Ser Ile His 
            260                 265                 270         


Gln Ala Leu Cys Trp Thr Gly Leu Phe Leu Arg Pro Ser Pro Phe Pro 
        275                 280                 285             


Arg Leu Pro Leu Ala Ala Pro Arg Thr Leu Arg Ala Gly Val 
    290                 295                 300         


<210>  1485
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  1485

Met Pro Gly Val Ala Arg Leu Pro Leu Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Arg Pro Gly Arg Pro Leu Asp Leu Ala Asp Tyr Thr Tyr Asp Leu 
            20                  25                  30          


Ala Glu Glu Asp Asp Ser Glu Pro Leu Asn Tyr Lys Asp Pro Cys Lys 
        35                  40                  45              


Ala Ala Ala Phe Leu Gly Asp Ile Ala Leu Asp Glu Glu Asp Leu Arg 
    50                  55                  60                  


Ala Phe Gln Val Gln Gln Ala Val Asp Leu Arg Arg His Thr Ala Arg 
65                  70                  75                  80  


Lys Ser Ser Ile Lys Ala Ala Val Pro Gly Asn Thr Ser Thr Pro Ser 
                85                  90                  95      


Cys Gln Ser Thr Asn Gly Gln Pro Gln Arg Gly Ala Cys Gly Arg Trp 
            100                 105                 110         


Arg Gly Arg Ser Arg Ser Arg Arg Ala Ala Thr Ser Arg Pro Glu Arg 
        115                 120                 125             


Val Trp Pro Asp Gly Val Ile Pro Phe Val Ile Gly Gly Asn Phe Thr 
    130                 135                 140                 


Gly Ser Gln Arg Ala Val Phe Arg Gln Ala Met Arg His Trp Glu Lys 
145                 150                 155                 160 


His Thr Cys Val Thr Phe Leu Glu Arg Thr Asp Glu Asp Ser Tyr Ile 
                165                 170                 175     


Val Phe Thr Tyr Arg Pro Cys Gly Ser Gly Pro Pro Pro 
            180                 185                 


<210>  1486
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  1486

Met Pro Gly Val Ala Arg Leu Pro Leu Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Arg Pro Gly Arg Pro Leu Asp Leu Ala Asp Tyr Thr Tyr Asp Leu 
            20                  25                  30          


Ala Glu Glu Asp Asp Ser Glu Pro Leu Asn Tyr Lys Asp Pro Cys Lys 
        35                  40                  45              


Ala Ala Ala Phe Leu Gly Asp Ile Ala Leu Asp Glu Glu Asp Leu Arg 
    50                  55                  60                  


Ala Phe Gln Val Gln Gln Ala Val Asp Leu Arg Arg His Thr Ala Arg 
65                  70                  75                  80  


Lys Ser Ser Ile Lys Ala Ala Val Pro Gly Asn Thr Ser Thr Pro Ser 
                85                  90                  95      


Cys Gln Ser Thr Asn Gly Gln Pro Gln Arg Gly Ala Cys Gly Arg Trp 
            100                 105                 110         


Arg Gly Arg Ser Arg Ser Arg Arg Ala Ala Thr Ser Arg Pro Glu Arg 
        115                 120                 125             


Val Trp Pro Asp Gly Val Ile Pro Phe Val Ile Gly Gly Asn Phe Thr 
    130                 135                 140                 


Gly Ser Gln Arg Ala Val Phe Arg Gln Ala Met Arg His Trp Glu Lys 
145                 150                 155                 160 


His Thr Cys Val Thr Phe Leu Glu Arg Thr Asp Glu Asp Ser Tyr Ile 
                165                 170                 175     


Val Phe Thr Tyr Arg Pro Cys Gly Ser Gly Pro Pro Pro 
            180                 185                 


<210>  1487
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  1487

Met Pro Gly Val Ala Arg Leu Pro Leu Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Arg Pro Gly Arg Pro Leu Asp Leu Ala Asp Tyr Thr Tyr Asp Leu 
            20                  25                  30          


Ala Glu Glu Asp Asp Ser Glu Pro Leu Asn Tyr Lys Asp Pro Cys Lys 
        35                  40                  45              


Ala Ala Ala Phe Leu Gly Asp Ile Ala Leu Asp Glu Glu Asp Leu Arg 
    50                  55                  60                  


Ala Phe Gln Val Gln Gln Ala Val Asp Leu Arg Arg His Thr Ala Arg 
65                  70                  75                  80  


Lys Ser Ser Ile Lys Ala Ala Val Pro Gly Asn Thr Ser Thr Pro Ser 
                85                  90                  95      


Cys Gln Ser Thr Asn Gly Gln Pro Gln Arg Gly Ala Cys Gly Arg Trp 
            100                 105                 110         


Arg Gly Arg Ser Arg Ser Arg Arg Ala Ala Thr Ser Arg Pro Glu Arg 
        115                 120                 125             


Val Trp Pro Asp Gly Val Ile Pro Phe Val Ile Gly Gly Asn Phe Thr 
    130                 135                 140                 


Gly Ser Gln Arg Ala Val Phe Arg Gln Ala Met Arg His Trp Glu Lys 
145                 150                 155                 160 


His Thr Cys Val Thr Phe Leu Glu Arg Thr Asp Glu Asp Ser Tyr Ile 
                165                 170                 175     


Val Phe Thr Tyr Arg Pro Cys Gly Ser Gly Pro Pro Pro 
            180                 185                 


<210>  1488
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  1488

Met Pro Gly Val Ala Arg Leu Pro Leu Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Arg Pro Gly Arg Pro Leu Asp Leu Ala Asp Tyr Thr Tyr Asp Leu 
            20                  25                  30          


Ala Glu Glu Asp Asp Ser Glu Pro Leu Asn Tyr Lys Asp Pro Cys Lys 
        35                  40                  45              


Ala Ala Ala Phe Leu Gly Asp Ile Ala Leu Asp Glu Glu Asp Leu Arg 
    50                  55                  60                  


Ala Phe Gln Val Gln Gln Ala Val Asp Leu Arg Arg His Thr Ala Arg 
65                  70                  75                  80  


Lys Ser Ser Ile Lys Ala Ala Val Pro Gly Asn Thr Ser Thr Pro Ser 
                85                  90                  95      


Cys Gln Ser Thr Asn Gly Gln Pro Gln Arg Gly Ala Cys Gly Arg Trp 
            100                 105                 110         


Arg Gly Arg Ser Arg Ser Arg Arg Ala Ala Thr Ser Arg Pro Glu Arg 
        115                 120                 125             


Val Trp Pro Asp Gly Val Ile Pro Phe Val Ile Gly Gly Asn Phe Thr 
    130                 135                 140                 


Gly Ser Gln Arg Ala Val Phe Arg Gln Ala Met Arg His Trp Glu Lys 
145                 150                 155                 160 


His Thr Cys Val Thr Phe Leu Glu Arg Thr Asp Glu Asp Ser Tyr Ile 
                165                 170                 175     


Val Phe Thr Tyr Arg Pro Cys Gly Ser Gly Pro Pro Pro 
            180                 185                 


<210>  1489
<211>  61
<212>  PRT
<213>  Homo Sapiens

<400>  1489

Met Pro Gly Val Ala Arg Leu Pro Leu Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Arg Pro Gly Arg Pro Leu Asp Leu Ala Asp Tyr Thr Tyr Asp Leu 
            20                  25                  30          


Ala Glu Glu Asp Asp Ser Glu Pro Leu Asn Tyr Lys Asp Pro Cys Lys 
        35                  40                  45              


Leu Pro Phe Leu Gly Thr Leu Pro Trp Thr Lys Arg Thr 
    50                  55                  60      


<210>  1490
<211>  424
<212>  PRT
<213>  Homo Sapiens

<400>  1490

Met Gly Ser Leu Val Leu Thr Leu Cys Ala Leu Phe Cys Leu Ala Ala 
1               5                   10                  15      


Tyr Leu Val Ser Gly Ser Pro Ile Met Asn Leu Glu Gln Ser Pro Leu 
            20                  25                  30          


Glu Glu Asp Met Ser Leu Phe Gly Asp Val Phe Ser Glu Gln Asp Gly 
        35                  40                  45              


Val Asp Phe Asn Thr Leu Leu Gln Ser Met Lys Asp Glu Phe Leu Lys 
    50                  55                  60                  


Thr Leu Asn Leu Ser Asp Ile Pro Thr Gln Asp Ser Ala Lys Val Asp 
65                  70                  75                  80  


Pro Pro Glu Tyr Met Leu Glu Leu Tyr Asn Lys Phe Ala Thr Asp Arg 
                85                  90                  95      


Thr Ser Met Pro Ser Ala Asn Ile Ile Arg Ser Phe Lys Asn Glu Asp 
            100                 105                 110         


Leu Phe Ser Gln Pro Val Ser Phe Asn Gly Leu Arg Lys Tyr Pro Leu 
        115                 120                 125             


Leu Phe Asn Val Ser Ile Pro His His Glu Glu Val Ile Met Ala Glu 
    130                 135                 140                 


Leu Arg Leu Tyr Thr Leu Val Gln Arg Asp Arg Met Ile Tyr Asp Gly 
145                 150                 155                 160 


Val Asp Arg Lys Ile Thr Ile Phe Glu Val Leu Glu Ser Lys Gly Asp 
                165                 170                 175     


Asn Glu Gly Glu Arg Asn Met Leu Val Leu Val Ser Gly Glu Ile Tyr 
            180                 185                 190         


Gly Thr Asn Ser Glu Trp Glu Thr Phe Asp Val Thr Asp Ala Ile Arg 
        195                 200                 205             


Arg Trp Gln Lys Ser Gly Ser Ser Thr His Gln Leu Glu Val His Ile 
    210                 215                 220                 


Glu Ser Lys His Asp Glu Ala Glu Asp Ala Ser Ser Gly Arg Leu Glu 
225                 230                 235                 240 


Ile Asp Thr Ser Ala Gln Asn Lys His Asn Pro Leu Leu Ile Val Phe 
                245                 250                 255     


Ser Asp Asp Gln Ser Ser Asp Lys Glu Arg Lys Glu Glu Leu Asn Glu 
            260                 265                 270         


Met Ile Ser His Glu Gln Leu Pro Glu Leu Asp Asn Leu Gly Leu Asp 
        275                 280                 285             


Ser Phe Ser Ser Gly Pro Gly Glu Glu Ala Leu Leu Gln Met Arg Ser 
    290                 295                 300                 


Asn Ile Ile Tyr Asp Ser Thr Ala Arg Ile Arg Arg Asn Ala Lys Gly 
305                 310                 315                 320 


Asn Tyr Cys Lys Arg Thr Pro Leu Tyr Ile Asp Phe Lys Glu Ile Gly 
                325                 330                 335     


Trp Asp Ser Trp Ile Ile Ala Pro Pro Gly Tyr Glu Ala Tyr Glu Cys 
            340                 345                 350         


Arg Gly Val Cys Asn Tyr Pro Leu Ala Glu His Leu Thr Pro Thr Lys 
        355                 360                 365             


His Ala Ile Ile Gln Ala Leu Val His Leu Lys Asn Ser Gln Lys Ala 
    370                 375                 380                 


Ser Lys Ala Cys Cys Val Pro Thr Lys Leu Glu Pro Ile Ser Ile Leu 
385                 390                 395                 400 


Tyr Leu Asp Lys Gly Val Val Thr Tyr Lys Phe Lys Tyr Glu Gly Met 
                405                 410                 415     


Ala Val Ser Glu Cys Gly Cys Arg 
            420                 


<210>  1491
<211>  392
<212>  PRT
<213>  Homo Sapiens

<400>  1491

Met Val Leu Leu Ser Ile Leu Arg Ile Leu Phe Leu Cys Glu Leu Val 
1               5                   10                  15      


Leu Phe Met Glu His Arg Ala Gln Met Ala Glu Gly Gly Gln Ser Ser 
            20                  25                  30          


Ile Ala Leu Leu Ala Glu Ala Pro Thr Leu Pro Leu Ile Glu Glu Leu 
        35                  40                  45              


Leu Glu Glu Ser Pro Gly Glu Gln Pro Arg Lys Pro Arg Leu Leu Gly 
    50                  55                  60                  


His Ser Leu Arg Tyr Met Leu Glu Leu Tyr Arg Arg Ser Ala Asp Ser 
65                  70                  75                  80  


His Gly His Pro Arg Glu Asn Arg Thr Ile Gly Ala Thr Met Val Arg 
                85                  90                  95      


Leu Val Lys Pro Leu Thr Asn Val Ala Arg Pro His Arg Gly Thr Trp 
            100                 105                 110         


His Ile Gln Ile Leu Gly Phe Pro Leu Arg Pro Asn Arg Gly Leu Tyr 
        115                 120                 125             


Gln Leu Val Arg Ala Thr Val Val Tyr Arg His His Leu Gln Leu Thr 
    130                 135                 140                 


Arg Phe Asn Leu Ser Cys His Val Glu Pro Trp Val Gln Lys Asn Pro 
145                 150                 155                 160 


Thr Asn His Phe Pro Ser Ser Glu Gly Asp Ser Ser Lys Pro Ser Leu 
                165                 170                 175     


Met Ser Asn Ala Trp Lys Glu Met Asp Ile Thr Gln Leu Val Gln Gln 
            180                 185                 190         


Arg Phe Trp Asn Asn Lys Gly His Arg Ile Leu Arg Leu Arg Phe Met 
        195                 200                 205             


Cys Gln Gln Gln Lys Asp Ser Gly Gly Leu Glu Leu Trp His Gly Thr 
    210                 215                 220                 


Ser Ser Leu Asp Ile Ala Phe Leu Leu Leu Tyr Phe Asn Asp Thr His 
225                 230                 235                 240 


Lys Ser Ile Arg Lys Ala Lys Phe Leu Pro Arg Gly Met Glu Glu Phe 
                245                 250                 255     


Met Glu Arg Glu Ser Leu Leu Arg Arg Thr Arg Gln Ala Asp Gly Ile 
            260                 265                 270         


Ser Ala Glu Val Thr Ala Ser Ser Ser Lys His Ser Gly Pro Glu Asn 
        275                 280                 285             


Asn Gln Cys Ser Leu His Pro Phe Gln Ile Ser Phe Arg Gln Leu Gly 
    290                 295                 300                 


Trp Asp His Trp Ile Ile Ala Pro Pro Phe Tyr Thr Pro Asn Tyr Cys 
305                 310                 315                 320 


Lys Gly Thr Cys Leu Arg Val Leu Arg Asp Gly Leu Asn Ser Pro Asn 
                325                 330                 335     


His Ala Ile Ile Gln Asn Leu Ile Asn Gln Leu Val Asp Gln Ser Val 
            340                 345                 350         


Pro Arg Pro Ser Cys Val Pro Tyr Lys Tyr Val Pro Ile Ser Val Leu 
        355                 360                 365             


Met Ile Glu Ala Asn Gly Ser Ile Leu Tyr Lys Glu Tyr Glu Gly Met 
    370                 375                 380                 


Ile Ala Glu Ser Cys Thr Cys Arg 
385                 390         


<210>  1492
<211>  396
<212>  PRT
<213>  Homo Sapiens

<400>  1492

Met Val Ala Gly Thr Arg Cys Leu Leu Ala Leu Leu Leu Pro Gln Val 
1               5                   10                  15      


Leu Leu Gly Gly Ala Ala Gly Leu Val Pro Glu Leu Gly Arg Arg Lys 
            20                  25                  30          


Phe Ala Ala Ala Ser Ser Gly Arg Pro Ser Ser Gln Pro Ser Asp Glu 
        35                  40                  45              


Val Leu Ser Glu Phe Glu Leu Arg Leu Leu Ser Met Phe Gly Leu Lys 
    50                  55                  60                  


Gln Arg Pro Thr Pro Ser Arg Asp Ala Val Val Pro Pro Tyr Met Leu 
65                  70                  75                  80  


Asp Leu Tyr Arg Arg His Ser Gly Gln Pro Gly Ser Pro Ala Pro Asp 
                85                  90                  95      


His Arg Leu Glu Arg Ala Ala Ser Arg Ala Asn Thr Val Arg Ser Phe 
            100                 105                 110         


His His Glu Glu Ser Leu Glu Glu Leu Pro Glu Thr Ser Gly Lys Thr 
        115                 120                 125             


Thr Arg Arg Phe Phe Phe Asn Leu Ser Ser Ile Pro Thr Glu Glu Phe 
    130                 135                 140                 


Ile Thr Ser Ala Glu Leu Gln Val Phe Arg Glu Gln Met Gln Asp Ala 
145                 150                 155                 160 


Leu Gly Asn Asn Ser Ser Phe His His Arg Ile Asn Ile Tyr Glu Ile 
                165                 170                 175     


Ile Lys Pro Ala Thr Ala Asn Ser Lys Phe Pro Val Thr Arg Leu Leu 
            180                 185                 190         


Asp Thr Arg Leu Val Asn Gln Asn Ala Ser Arg Trp Glu Ser Phe Asp 
        195                 200                 205             


Val Thr Pro Ala Val Met Arg Trp Thr Ala Gln Gly His Ala Asn His 
    210                 215                 220                 


Gly Phe Val Val Glu Val Ala His Leu Glu Glu Lys Gln Gly Val Ser 
225                 230                 235                 240 


Lys Arg His Val Arg Ile Ser Arg Ser Leu His Gln Asp Glu His Ser 
                245                 250                 255     


Trp Ser Gln Ile Arg Pro Leu Leu Val Thr Phe Gly His Asp Gly Lys 
            260                 265                 270         


Gly His Pro Leu His Lys Arg Glu Lys Arg Gln Ala Lys His Lys Gln 
        275                 280                 285             


Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr Val Asp 
    290                 295                 300                 


Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr 
305                 310                 315                 320 


His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala Asp His 
                325                 330                 335     


Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val 
            340                 345                 350         


Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala 
        355                 360                 365             


Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys Asn 
    370                 375                 380                 


Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
385                 390                 395     


<210>  1493
<211>  472
<212>  PRT
<213>  Homo Sapiens

<400>  1493

Met Ala Gly Ala Ser Arg Leu Leu Phe Leu Trp Leu Gly Cys Phe Cys 
1               5                   10                  15      


Val Ser Leu Ala Gln Gly Glu Arg Pro Lys Pro Pro Phe Pro Glu Leu 
            20                  25                  30          


Arg Lys Ala Val Pro Gly Asp Arg Thr Ala Gly Gly Gly Pro Asp Ser 
        35                  40                  45              


Glu Leu Gln Pro Gln Asp Lys Val Ser Glu His Met Leu Arg Leu Tyr 
    50                  55                  60                  


Asp Arg Tyr Ser Thr Val Gln Ala Ala Arg Thr Pro Gly Ser Leu Glu 
65                  70                  75                  80  


Gly Gly Ser Gln Pro Trp Arg Pro Arg Leu Leu Arg Glu Gly Asn Thr 
                85                  90                  95      


Val Arg Ser Phe Arg Ala Ala Ala Ala Glu Thr Leu Glu Arg Lys Gly 
            100                 105                 110         


Leu Tyr Ile Phe Asn Leu Thr Ser Leu Thr Lys Ser Glu Asn Ile Leu 
        115                 120                 125             


Ser Ala Thr Leu Tyr Phe Cys Ile Gly Glu Leu Gly Asn Ile Ser Leu 
    130                 135                 140                 


Ser Cys Pro Val Ser Gly Gly Cys Ser His His Ala Gln Arg Lys His 
145                 150                 155                 160 


Ile Gln Ile Asp Leu Ser Ala Trp Thr Leu Lys Phe Ser Arg Asn Gln 
                165                 170                 175     


Ser Gln Leu Leu Gly His Leu Ser Val Asp Met Ala Lys Ser His Arg 
            180                 185                 190         


Asp Ile Met Ser Trp Leu Ser Lys Asp Ile Thr Gln Leu Leu Arg Lys 
        195                 200                 205             


Ala Lys Glu Asn Glu Glu Phe Leu Ile Gly Phe Asn Ile Thr Ser Lys 
    210                 215                 220                 


Gly Arg Gln Leu Pro Lys Arg Arg Leu Pro Phe Pro Glu Pro Tyr Ile 
225                 230                 235                 240 


Leu Val Tyr Ala Asn Asp Ala Ala Ile Ser Glu Pro Glu Ser Val Val 
                245                 250                 255     


Ser Ser Leu Gln Gly His Arg Asn Phe Pro Thr Gly Thr Val Pro Lys 
            260                 265                 270         


Trp Asp Ser His Ile Arg Ala Ala Leu Ser Ile Glu Arg Arg Lys Lys 
        275                 280                 285             


Arg Ser Thr Gly Val Leu Leu Pro Leu Gln Asn Asn Glu Leu Pro Gly 
    290                 295                 300                 


Ala Glu Tyr Gln Tyr Lys Lys Asp Glu Val Trp Glu Glu Arg Lys Pro 
305                 310                 315                 320 


Tyr Lys Thr Leu Gln Ala Gln Ala Pro Glu Lys Ser Lys Asn Lys Lys 
                325                 330                 335     


Lys Gln Arg Lys Gly Pro His Arg Lys Ser Gln Thr Leu Gln Phe Asp 
            340                 345                 350         


Glu Gln Thr Leu Lys Lys Ala Arg Arg Lys Gln Trp Ile Glu Pro Arg 
        355                 360                 365             


Asn Cys Ala Arg Arg Tyr Leu Lys Val Asp Phe Ala Asp Ile Gly Trp 
    370                 375                 380                 


Ser Glu Trp Ile Ile Ser Pro Lys Ser Phe Asp Ala Tyr Tyr Cys Ser 
385                 390                 395                 400 


Gly Ala Cys Gln Phe Pro Met Pro Lys Ser Leu Lys Pro Ser Asn His 
                405                 410                 415     


Ala Thr Ile Gln Ser Ile Val Arg Ala Val Gly Val Val Pro Gly Ile 
            420                 425                 430         


Pro Glu Pro Cys Cys Val Pro Glu Lys Met Ser Ser Leu Ser Ile Leu 
        435                 440                 445             


Phe Phe Asp Glu Asn Lys Asn Val Val Leu Lys Val Tyr Pro Asn Met 
    450                 455                 460                 


Thr Val Glu Ser Cys Ala Cys Arg 
465                 470         


<210>  1494
<211>  104
<212>  PRT
<213>  Homo Sapiens

<400>  1494

Leu Ile Pro Glu Thr Gly Lys Lys Lys Val Ala Glu Ile Gln Gly His 
1               5                   10                  15      


Ala Gly Gly Arg Arg Ser Gly Gln Ser His Glu Leu Leu Arg Asp Phe 
            20                  25                  30          


Glu Ala Thr Leu Leu Gln Met Phe Gly Leu Arg Arg Arg Pro Gln Pro 
        35                  40                  45              


Ser Lys Ser Ala Val Ile Pro Asp Tyr Met Arg Asp Leu Tyr Arg Leu 
    50                  55                  60                  


Gln Ser Gly Glu Glu Glu Glu Glu Gln Ile His Ser Thr Gly Leu Glu 
65                  70                  75                  80  


Tyr Pro Glu Arg Pro Ala Ser Arg Ala Asn Thr Val Arg Ser Phe His 
                85                  90                  95      


His Glu Ala Ser Leu Arg Thr Arg 
            100                 


<210>  1495
<211>  271
<212>  PRT
<213>  Homo Sapiens

<400>  1495

Met Phe Gly Leu Arg Arg Arg Pro Gln Pro Ser Lys Ser Ala Val Ile 
1               5                   10                  15      


Pro Asp Tyr Met Arg Asp Leu Tyr Arg Leu Gln Ser Gly Glu Glu Glu 
            20                  25                  30          


Glu Glu Gln Ile His Ser Thr Gly Leu Glu Tyr Pro Glu Arg Pro Ala 
        35                  40                  45              


Ser Arg Ala Asn Thr Val Arg Ser Phe His His Glu Glu His Leu Glu 
    50                  55                  60                  


Asn Ile Pro Gly Thr Ser Glu Asn Ser Ala Phe Arg Phe Leu Phe Asn 
65                  70                  75                  80  


Leu Ser Ser Ile Pro Glu Asn Glu Val Ile Ser Ser Ala Glu Leu Arg 
                85                  90                  95      


Leu Phe Arg Glu Gln Val Asp Gln Gly Pro Asp Trp Glu Arg Gly Phe 
            100                 105                 110         


His Arg Ile Asn Ile Tyr Glu Val Met Lys Pro Pro Ala Glu Val Val 
        115                 120                 125             


Pro Gly His Leu Ile Thr Arg Leu Leu Asp Thr Arg Leu Val His His 
    130                 135                 140                 


Asn Val Thr Arg Trp Glu Thr Phe Asp Val Ser Pro Ala Val Leu Arg 
145                 150                 155                 160 


Trp Thr Arg Glu Lys Gln Pro Asn Tyr Gly Leu Ala Ile Glu Val Thr 
                165                 170                 175     


His Leu His Gln Thr Arg Thr His Gln Gly Gln His Val Arg Ile Ser 
            180                 185                 190         


Arg Ser Leu Pro Gln Gly Ser Gly Asn Trp Ala Gln Leu Arg Pro Leu 
        195                 200                 205             


Leu Val Thr Phe Gly His Asp Gly Arg Gly His Ala Leu Thr Arg Arg 
    210                 215                 220                 


Arg Arg Ala Lys Arg Ser Pro Lys His His Ser Gln Arg Ala Arg Lys 
225                 230                 235                 240 


Lys Asn Lys Asn Cys Arg Arg His Ser Leu Tyr Val Asp Phe Ser Asp 
                245                 250                 255     


Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr Gln Ala 
            260                 265                 270     


<210>  1496
<211>  110
<212>  PRT
<213>  Homo Sapiens

<400>  1496

Met Ile Pro Gly Asn Arg Met Leu Met Val Val Leu Leu Cys Gln Val 
1               5                   10                  15      


Leu Leu Gly Gly Ala Ser His Ala Ser Leu Ile Pro Glu Thr Gly Lys 
            20                  25                  30          


Lys Lys Val Ala Glu Ile Gln Gly His Ala Gly Gly Arg Arg Ser Gly 
        35                  40                  45              


Gln Ser His Glu Leu Leu Arg Asp Phe Glu Ala Thr Leu Leu Gln Met 
    50                  55                  60                  


Phe Gly Leu Arg Arg Arg Pro Gln Pro Ser Lys Ser Ala Val Ile Pro 
65                  70                  75                  80  


Asp Tyr Met Arg Asp Leu Tyr Arg Leu Gln Ser Gly Glu Glu Glu Glu 
                85                  90                  95      


Glu Gln Ile His Ser Thr Gly Leu Glu Tyr Pro Glu Arg Pro 
            100                 105                 110 


<210>  1497
<211>  408
<212>  PRT
<213>  Homo Sapiens

<400>  1497

Met Ile Pro Gly Asn Arg Met Leu Met Val Val Leu Leu Cys Gln Val 
1               5                   10                  15      


Leu Leu Gly Gly Ala Ser His Ala Ser Leu Ile Pro Glu Thr Gly Lys 
            20                  25                  30          


Lys Lys Val Ala Glu Ile Gln Gly His Ala Gly Gly Arg Arg Ser Gly 
        35                  40                  45              


Gln Ser His Glu Leu Leu Arg Asp Phe Glu Ala Thr Leu Leu Gln Met 
    50                  55                  60                  


Phe Gly Leu Arg Arg Arg Pro Gln Pro Ser Lys Ser Ala Val Ile Pro 
65                  70                  75                  80  


Asp Tyr Met Arg Asp Leu Tyr Arg Leu Gln Ser Gly Glu Glu Glu Glu 
                85                  90                  95      


Glu Gln Ile His Ser Thr Gly Leu Glu Tyr Pro Glu Arg Pro Ala Ser 
            100                 105                 110         


Arg Ala Asn Thr Val Arg Ser Phe His His Glu Glu His Leu Glu Asn 
        115                 120                 125             


Ile Pro Gly Thr Ser Glu Asn Ser Ala Phe Arg Phe Leu Phe Asn Leu 
    130                 135                 140                 


Ser Ser Ile Pro Glu Asn Glu Val Ile Ser Ser Ala Glu Leu Arg Leu 
145                 150                 155                 160 


Phe Arg Glu Gln Val Asp Gln Gly Pro Asp Trp Glu Arg Gly Phe His 
                165                 170                 175     


Arg Ile Asn Ile Tyr Glu Val Met Lys Pro Pro Ala Glu Val Val Pro 
            180                 185                 190         


Gly His Leu Ile Thr Arg Leu Leu Asp Thr Arg Leu Val His His Asn 
        195                 200                 205             


Val Thr Arg Trp Glu Thr Phe Asp Val Ser Pro Ala Val Leu Arg Trp 
    210                 215                 220                 


Thr Arg Glu Lys Gln Pro Asn Tyr Gly Leu Ala Ile Glu Val Thr His 
225                 230                 235                 240 


Leu His Gln Thr Arg Thr His Gln Gly Gln His Val Arg Ile Ser Arg 
                245                 250                 255     


Ser Leu Pro Gln Gly Ser Gly Asn Trp Ala Gln Leu Arg Pro Leu Leu 
            260                 265                 270         


Val Thr Phe Gly His Asp Gly Arg Gly His Ala Leu Thr Arg Arg Arg 
        275                 280                 285             


Arg Ala Lys Arg Ser Pro Lys His His Ser Gln Arg Ala Arg Lys Lys 
    290                 295                 300                 


Asn Lys Asn Cys Arg Arg His Ser Leu Tyr Val Asp Phe Ser Asp Val 
305                 310                 315                 320 


Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr Gln Ala Phe Tyr 
                325                 330                 335     


Cys His Gly Asp Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr 
            340                 345                 350         


Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val Asn Ser Ser Ile 
        355                 360                 365             


Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu 
    370                 375                 380                 


Tyr Leu Asp Glu Tyr Asp Lys Val Val Leu Lys Asn Tyr Gln Glu Met 
385                 390                 395                 400 


Val Val Glu Gly Cys Gly Cys Arg 
                405             


<210>  1498
<211>  408
<212>  PRT
<213>  Homo Sapiens

<400>  1498

Met Ile Pro Gly Asn Arg Met Leu Met Val Val Leu Leu Cys Gln Val 
1               5                   10                  15      


Leu Leu Gly Gly Ala Ser His Ala Ser Leu Ile Pro Glu Thr Gly Lys 
            20                  25                  30          


Lys Lys Val Ala Glu Ile Gln Gly His Ala Gly Gly Arg Arg Ser Gly 
        35                  40                  45              


Gln Ser His Glu Leu Leu Arg Asp Phe Glu Ala Thr Leu Leu Gln Met 
    50                  55                  60                  


Phe Gly Leu Arg Arg Arg Pro Gln Pro Ser Lys Ser Ala Val Ile Pro 
65                  70                  75                  80  


Asp Tyr Met Arg Asp Leu Tyr Arg Leu Gln Ser Gly Glu Glu Glu Glu 
                85                  90                  95      


Glu Gln Ile His Ser Thr Gly Leu Glu Tyr Pro Glu Arg Pro Ala Ser 
            100                 105                 110         


Arg Ala Asn Thr Val Arg Ser Phe His His Glu Glu His Leu Glu Asn 
        115                 120                 125             


Ile Pro Gly Thr Ser Glu Asn Ser Ala Phe Arg Phe Leu Phe Asn Leu 
    130                 135                 140                 


Ser Ser Ile Pro Glu Asn Glu Val Ile Ser Ser Ala Glu Leu Arg Leu 
145                 150                 155                 160 


Phe Arg Glu Gln Val Asp Gln Gly Pro Asp Trp Glu Arg Gly Phe His 
                165                 170                 175     


Arg Ile Asn Ile Tyr Glu Val Met Lys Pro Pro Ala Glu Val Val Pro 
            180                 185                 190         


Gly His Leu Ile Thr Arg Leu Leu Asp Thr Arg Leu Val His His Asn 
        195                 200                 205             


Val Thr Arg Trp Glu Thr Phe Asp Val Ser Pro Ala Val Leu Arg Trp 
    210                 215                 220                 


Thr Arg Glu Lys Gln Pro Asn Tyr Gly Leu Ala Ile Glu Val Thr His 
225                 230                 235                 240 


Leu His Gln Thr Arg Thr His Gln Gly Gln His Val Arg Ile Ser Arg 
                245                 250                 255     


Ser Leu Pro Gln Gly Ser Gly Asn Trp Ala Gln Leu Arg Pro Leu Leu 
            260                 265                 270         


Val Thr Phe Gly His Asp Gly Arg Gly His Ala Leu Thr Arg Arg Arg 
        275                 280                 285             


Arg Ala Lys Arg Ser Pro Lys His His Ser Gln Arg Ala Arg Lys Lys 
    290                 295                 300                 


Asn Lys Asn Cys Arg Arg His Ser Leu Tyr Val Asp Phe Ser Asp Val 
305                 310                 315                 320 


Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr Gln Ala Phe Tyr 
                325                 330                 335     


Cys His Gly Asp Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr 
            340                 345                 350         


Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val Asn Ser Ser Ile 
        355                 360                 365             


Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu 
    370                 375                 380                 


Tyr Leu Asp Glu Tyr Asp Lys Val Val Leu Lys Asn Tyr Gln Glu Met 
385                 390                 395                 400 


Val Val Glu Gly Cys Gly Cys Arg 
                405             


<210>  1499
<211>  408
<212>  PRT
<213>  Homo Sapiens

<400>  1499

Met Ile Pro Gly Asn Arg Met Leu Met Val Val Leu Leu Cys Gln Val 
1               5                   10                  15      


Leu Leu Gly Gly Ala Ser His Ala Ser Leu Ile Pro Glu Thr Gly Lys 
            20                  25                  30          


Lys Lys Val Ala Glu Ile Gln Gly His Ala Gly Gly Arg Arg Ser Gly 
        35                  40                  45              


Gln Ser His Glu Leu Leu Arg Asp Phe Glu Ala Thr Leu Leu Gln Met 
    50                  55                  60                  


Phe Gly Leu Arg Arg Arg Pro Gln Pro Ser Lys Ser Ala Val Ile Pro 
65                  70                  75                  80  


Asp Tyr Met Arg Asp Leu Tyr Arg Leu Gln Ser Gly Glu Glu Glu Glu 
                85                  90                  95      


Glu Gln Ile His Ser Thr Gly Leu Glu Tyr Pro Glu Arg Pro Ala Ser 
            100                 105                 110         


Arg Ala Asn Thr Val Arg Ser Phe His His Glu Glu His Leu Glu Asn 
        115                 120                 125             


Ile Pro Gly Thr Ser Glu Asn Ser Ala Phe Arg Phe Leu Phe Asn Leu 
    130                 135                 140                 


Ser Ser Ile Pro Glu Asn Glu Val Ile Ser Ser Ala Glu Leu Arg Leu 
145                 150                 155                 160 


Phe Arg Glu Gln Val Asp Gln Gly Pro Asp Trp Glu Arg Gly Phe His 
                165                 170                 175     


Arg Ile Asn Ile Tyr Glu Val Met Lys Pro Pro Ala Glu Val Val Pro 
            180                 185                 190         


Gly His Leu Ile Thr Arg Leu Leu Asp Thr Arg Leu Val His His Asn 
        195                 200                 205             


Val Thr Arg Trp Glu Thr Phe Asp Val Ser Pro Ala Val Leu Arg Trp 
    210                 215                 220                 


Thr Arg Glu Lys Gln Pro Asn Tyr Gly Leu Ala Ile Glu Val Thr His 
225                 230                 235                 240 


Leu His Gln Thr Arg Thr His Gln Gly Gln His Val Arg Ile Ser Arg 
                245                 250                 255     


Ser Leu Pro Gln Gly Ser Gly Asn Trp Ala Gln Leu Arg Pro Leu Leu 
            260                 265                 270         


Val Thr Phe Gly His Asp Gly Arg Gly His Ala Leu Thr Arg Arg Arg 
        275                 280                 285             


Arg Ala Lys Arg Ser Pro Lys His His Ser Gln Arg Ala Arg Lys Lys 
    290                 295                 300                 


Asn Lys Asn Cys Arg Arg His Ser Leu Tyr Val Asp Phe Ser Asp Val 
305                 310                 315                 320 


Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr Gln Ala Phe Tyr 
                325                 330                 335     


Cys His Gly Asp Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr 
            340                 345                 350         


Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val Asn Ser Ser Ile 
        355                 360                 365             


Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu 
    370                 375                 380                 


Tyr Leu Asp Glu Tyr Asp Lys Val Val Leu Lys Asn Tyr Gln Glu Met 
385                 390                 395                 400 


Val Val Glu Gly Cys Gly Cys Arg 
                405             


<210>  1500
<211>  408
<212>  PRT
<213>  Homo Sapiens

<400>  1500

Met Ile Pro Gly Asn Arg Met Leu Met Val Val Leu Leu Cys Gln Val 
1               5                   10                  15      


Leu Leu Gly Gly Ala Ser His Ala Ser Leu Ile Pro Glu Thr Gly Lys 
            20                  25                  30          


Lys Lys Val Ala Glu Ile Gln Gly His Ala Gly Gly Arg Arg Ser Gly 
        35                  40                  45              


Gln Ser His Glu Leu Leu Arg Asp Phe Glu Ala Thr Leu Leu Gln Met 
    50                  55                  60                  


Phe Gly Leu Arg Arg Arg Pro Gln Pro Ser Lys Ser Ala Val Ile Pro 
65                  70                  75                  80  


Asp Tyr Met Arg Asp Leu Tyr Arg Leu Gln Ser Gly Glu Glu Glu Glu 
                85                  90                  95      


Glu Gln Ile His Ser Thr Gly Leu Glu Tyr Pro Glu Arg Pro Ala Ser 
            100                 105                 110         


Arg Ala Asn Thr Val Arg Ser Phe His His Glu Glu His Leu Glu Asn 
        115                 120                 125             


Ile Pro Gly Thr Ser Glu Asn Ser Ala Phe Arg Phe Leu Phe Asn Leu 
    130                 135                 140                 


Ser Ser Ile Pro Glu Asn Glu Val Ile Ser Ser Ala Glu Leu Arg Leu 
145                 150                 155                 160 


Phe Arg Glu Gln Val Asp Gln Gly Pro Asp Trp Glu Arg Gly Phe His 
                165                 170                 175     


Arg Ile Asn Ile Tyr Glu Val Met Lys Pro Pro Ala Glu Val Val Pro 
            180                 185                 190         


Gly His Leu Ile Thr Arg Leu Leu Asp Thr Arg Leu Val His His Asn 
        195                 200                 205             


Val Thr Arg Trp Glu Thr Phe Asp Val Ser Pro Ala Val Leu Arg Trp 
    210                 215                 220                 


Thr Arg Glu Lys Gln Pro Asn Tyr Gly Leu Ala Ile Glu Val Thr His 
225                 230                 235                 240 


Leu His Gln Thr Arg Thr His Gln Gly Gln His Val Arg Ile Ser Arg 
                245                 250                 255     


Ser Leu Pro Gln Gly Ser Gly Asn Trp Ala Gln Leu Arg Pro Leu Leu 
            260                 265                 270         


Val Thr Phe Gly His Asp Gly Arg Gly His Ala Leu Thr Arg Arg Arg 
        275                 280                 285             


Arg Ala Lys Arg Ser Pro Lys His His Ser Gln Arg Ala Arg Lys Lys 
    290                 295                 300                 


Asn Lys Asn Cys Arg Arg His Ser Leu Tyr Val Asp Phe Ser Asp Val 
305                 310                 315                 320 


Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr Gln Ala Phe Tyr 
                325                 330                 335     


Cys His Gly Asp Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr 
            340                 345                 350         


Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val Asn Ser Ser Ile 
        355                 360                 365             


Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu 
    370                 375                 380                 


Tyr Leu Asp Glu Tyr Asp Lys Val Val Leu Lys Asn Tyr Gln Glu Met 
385                 390                 395                 400 


Val Val Glu Gly Cys Gly Cys Arg 
                405             


<210>  1501
<211>  29
<212>  PRT
<213>  Homo Sapiens

<400>  1501

Asn Thr Val Arg Ser Phe His His Glu Gly Gln Ser Leu Pro Pro Val 
1               5                   10                  15      


Cys Val Gly Glu Gly Trp Trp Asp Trp Leu Glu Gly Gln 
            20                  25                  


<210>  1502
<211>  513
<212>  PRT
<213>  Homo Sapiens

<400>  1502

Met Pro Gly Leu Gly Arg Arg Ala Gln Trp Leu Cys Trp Trp Trp Gly 
1               5                   10                  15      


Leu Leu Cys Ser Cys Cys Gly Pro Pro Pro Leu Arg Pro Pro Leu Pro 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Gly Gly Gln Leu Leu Gly Asp Gly Gly 
        35                  40                  45              


Ser Pro Gly Arg Thr Glu Gln Pro Pro Pro Ser Pro Gln Ser Ser Ser 
    50                  55                  60                  


Gly Phe Leu Tyr Arg Arg Leu Lys Thr Gln Glu Lys Arg Glu Met Gln 
65                  70                  75                  80  


Lys Glu Ile Leu Ser Val Leu Gly Leu Pro His Arg Pro Arg Pro Leu 
                85                  90                  95      


His Gly Leu Gln Gln Pro Gln Pro Pro Ala Leu Arg Gln Gln Glu Glu 
            100                 105                 110         


Gln Gln Gln Gln Gln Gln Leu Pro Arg Gly Glu Pro Pro Pro Gly Arg 
        115                 120                 125             


Leu Lys Ser Ala Pro Leu Phe Met Leu Asp Leu Tyr Asn Ala Leu Ser 
    130                 135                 140                 


Ala Asp Asn Asp Glu Asp Gly Ala Ser Glu Gly Glu Arg Gln Gln Ser 
145                 150                 155                 160 


Trp Pro His Glu Ala Ala Ser Ser Ser Gln Arg Arg Gln Pro Pro Pro 
                165                 170                 175     


Gly Ala Ala His Pro Leu Asn Arg Lys Ser Leu Leu Ala Pro Gly Ser 
            180                 185                 190         


Gly Ser Gly Gly Ala Ser Pro Leu Thr Ser Ala Gln Asp Ser Ala Phe 
        195                 200                 205             


Leu Asn Asp Ala Asp Met Val Met Ser Phe Val Asn Leu Val Glu Tyr 
    210                 215                 220                 


Asp Lys Glu Phe Ser Pro Arg Gln Arg His His Lys Glu Phe Lys Phe 
225                 230                 235                 240 


Asn Leu Ser Gln Ile Pro Glu Gly Glu Val Val Thr Ala Ala Glu Phe 
                245                 250                 255     


Arg Ile Tyr Lys Asp Cys Val Met Gly Ser Phe Lys Asn Gln Thr Phe 
            260                 265                 270         


Leu Ile Ser Ile Tyr Gln Val Leu Gln Glu His Gln His Arg Asp Ser 
        275                 280                 285             


Asp Leu Phe Leu Leu Asp Thr Arg Val Val Trp Ala Ser Glu Glu Gly 
    290                 295                 300                 


Trp Leu Glu Phe Asp Ile Thr Ala Thr Ser Asn Leu Trp Val Val Thr 
305                 310                 315                 320 


Pro Gln His Asn Met Gly Leu Gln Leu Ser Val Val Thr Arg Asp Gly 
                325                 330                 335     


Val His Val His Pro Arg Ala Ala Gly Leu Val Gly Arg Asp Gly Pro 
            340                 345                 350         


Tyr Asp Lys Gln Pro Phe Met Val Ala Phe Phe Lys Val Ser Glu Val 
        355                 360                 365             


His Val Arg Thr Thr Arg Ser Ala Ser Ser Arg Arg Arg Gln Gln Ser 
    370                 375                 380                 


Arg Asn Arg Ser Thr Gln Ser Gln Asp Val Ala Arg Val Ser Ser Ala 
385                 390                 395                 400 


Ser Asp Tyr Asn Ser Ser Glu Leu Lys Thr Ala Cys Arg Lys His Glu 
                405                 410                 415     


Leu Tyr Val Ser Phe Gln Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala 
            420                 425                 430         


Pro Lys Gly Tyr Ala Ala Asn Tyr Cys Asp Gly Glu Cys Ser Phe Pro 
        435                 440                 445             


Leu Asn Ala His Met Asn Ala Thr Asn His Ala Ile Val Gln Thr Leu 
    450                 455                 460                 


Val His Leu Met Asn Pro Glu Tyr Val Pro Lys Pro Cys Cys Ala Pro 
465                 470                 475                 480 


Thr Lys Leu Asn Ala Ile Ser Val Leu Tyr Phe Asp Asp Asn Ser Asn 
                485                 490                 495     


Val Ile Leu Lys Lys Tyr Arg Asn Met Val Val Arg Ala Cys Gly Cys 
            500                 505                 510         


His 
    


<210>  1503
<211>  365
<212>  PRT
<213>  Homo Sapiens

<400>  1503

Met His Val Arg Ser Leu Arg Ala Ala Ala Pro His Ser Phe Val Ala 
1               5                   10                  15      


Leu Trp Ala Pro Leu Phe Leu Leu Arg Ser Ala Leu Ala Asp Phe Ser 
            20                  25                  30          


Leu Asp Asn Glu Val His Ser Ser Phe Ile His Arg Arg Leu Arg Ser 
        35                  40                  45              


Gln Glu Arg Arg Glu Met Gln Arg Glu Ile Leu Ser Ile Leu Gly Leu 
    50                  55                  60                  


Pro His Arg Pro Arg Pro His Leu Gln Gly Lys His Asn Ser Ala Pro 
65                  70                  75                  80  


Met Phe Met Leu Asp Leu Tyr Asn Ala Met Ala Val Glu Glu Gly Gly 
                85                  90                  95      


Gly Pro Gly Gly Gln Gly Phe Ser Tyr Pro Tyr Lys Ala Val Phe Ser 
            100                 105                 110         


Thr Gln Gly Pro Pro Leu Ala Ser Leu Gln Asp Ser His Phe Leu Thr 
        115                 120                 125             


Asp Ala Asp Met Val Met Ser Phe Val Asn Leu Val Glu His Asp Lys 
    130                 135                 140                 


Glu Phe Phe His Pro Arg Tyr His His Arg Glu Phe Arg Phe Asp Leu 
145                 150                 155                 160 


Ser Lys Ile Pro Glu Gly Glu Ala Val Thr Ala Ala Glu Phe Arg Ile 
                165                 170                 175     


Tyr Lys Asp Tyr Ile Arg Glu Arg Phe Asp Asn Glu Thr Phe Arg Ile 
            180                 185                 190         


Ser Val Tyr Gln Val Leu Gln Glu His Leu Gly Arg Glu Ser Asp Leu 
        195                 200                 205             


Phe Leu Leu Asp Ser Arg Thr Leu Trp Ala Ser Glu Glu Gly Trp Leu 
    210                 215                 220                 


Val Phe Asp Ile Thr Ala Thr Ser Asn His Trp Val Val Asn Pro Arg 
225                 230                 235                 240 


His Asn Leu Gly Leu Gln Leu Ser Val Glu Thr Leu Asp Glu Asn Ser 
                245                 250                 255     


Ser Ser Asp Gln Arg Gln Ala Cys Lys Lys His Glu Leu Tyr Val Ser 
            260                 265                 270         


Phe Arg Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala Pro Glu Gly Tyr 
        275                 280                 285             


Ala Ala Tyr Tyr Cys Glu Gly Glu Cys Ala Phe Pro Leu Asn Ser Tyr 
    290                 295                 300                 


Met Asn Ala Thr Asn His Ala Ile Val Gln Thr Leu Val His Phe Ile 
305                 310                 315                 320 


Asn Pro Glu Thr Val Pro Lys Pro Cys Cys Ala Pro Thr Gln Leu Asn 
                325                 330                 335     


Ala Ile Ser Val Leu Tyr Phe Asp Asp Ser Ser Asn Val Ile Leu Lys 
            340                 345                 350         


Lys Tyr Arg Asn Met Val Val Arg Ala Cys Gly Cys His 
        355                 360                 365 


<210>  1504
<211>  431
<212>  PRT
<213>  Homo Sapiens

<400>  1504

Met His Val Arg Ser Leu Arg Ala Ala Ala Pro His Ser Phe Val Ala 
1               5                   10                  15      


Leu Trp Ala Pro Leu Phe Leu Leu Arg Ser Ala Leu Ala Asp Phe Ser 
            20                  25                  30          


Leu Asp Asn Glu Val His Ser Ser Phe Ile His Arg Arg Leu Arg Ser 
        35                  40                  45              


Gln Glu Arg Arg Glu Met Gln Arg Glu Ile Leu Ser Ile Leu Gly Leu 
    50                  55                  60                  


Pro His Arg Pro Arg Pro His Leu Gln Gly Lys His Asn Ser Ala Pro 
65                  70                  75                  80  


Met Phe Met Leu Asp Leu Tyr Asn Ala Met Ala Val Glu Glu Gly Gly 
                85                  90                  95      


Gly Pro Gly Gly Gln Gly Phe Ser Tyr Pro Tyr Lys Ala Val Phe Ser 
            100                 105                 110         


Thr Gln Gly Pro Pro Leu Ala Ser Leu Gln Asp Ser His Phe Leu Thr 
        115                 120                 125             


Asp Ala Asp Met Val Met Ser Phe Val Asn Leu Val Glu His Asp Lys 
    130                 135                 140                 


Glu Phe Phe His Pro Arg Tyr His His Arg Glu Phe Arg Phe Asp Leu 
145                 150                 155                 160 


Ser Lys Ile Pro Glu Gly Glu Ala Val Thr Ala Ala Glu Phe Arg Ile 
                165                 170                 175     


Tyr Lys Asp Tyr Ile Arg Glu Arg Phe Asp Asn Glu Thr Phe Arg Ile 
            180                 185                 190         


Ser Val Tyr Gln Val Leu Gln Glu His Leu Gly Arg Glu Ser Asp Leu 
        195                 200                 205             


Phe Leu Leu Asp Ser Arg Thr Leu Trp Ala Ser Glu Glu Gly Trp Leu 
    210                 215                 220                 


Val Phe Asp Ile Thr Ala Thr Ser Asn His Trp Val Val Asn Pro Arg 
225                 230                 235                 240 


His Asn Leu Gly Leu Gln Leu Ser Val Glu Thr Leu Asp Gly Gln Ser 
                245                 250                 255     


Ile Asn Pro Lys Leu Ala Gly Leu Ile Gly Arg His Gly Pro Gln Asn 
            260                 265                 270         


Lys Gln Pro Phe Met Val Ala Phe Phe Lys Ala Thr Glu Val His Phe 
        275                 280                 285             


Arg Ser Ile Arg Ser Thr Gly Ser Lys Gln Arg Ser Gln Asn Arg Ser 
    290                 295                 300                 


Lys Thr Pro Lys Asn Gln Glu Ala Leu Arg Met Ala Asn Val Ala Glu 
305                 310                 315                 320 


Asn Ser Ser Ser Asp Gln Arg Gln Ala Cys Lys Lys His Glu Leu Tyr 
                325                 330                 335     


Val Ser Phe Arg Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala Pro Glu 
            340                 345                 350         


Gly Tyr Ala Ala Tyr Tyr Cys Glu Gly Glu Cys Ala Phe Pro Leu Asn 
        355                 360                 365             


Ser Tyr Met Asn Ala Thr Asn His Ala Ile Val Gln Thr Leu Val His 
    370                 375                 380                 


Phe Ile Asn Pro Glu Thr Val Pro Lys Pro Cys Cys Ala Pro Thr Gln 
385                 390                 395                 400 


Leu Asn Ala Ile Ser Val Leu Tyr Phe Asp Asp Ser Ser Asn Val Ile 
                405                 410                 415     


Leu Lys Lys Tyr Arg Asn Met Val Val Arg Ala Cys Gly Cys His 
            420                 425                 430     


<210>  1505
<211>  412
<212>  PRT
<213>  Homo Sapiens

<400>  1505

Met His Val Arg Ser Leu Arg Ala Ala Ala Pro His Ser Phe Val Ala 
1               5                   10                  15      


Leu Trp Ala Pro Leu Phe Leu Leu Arg Ser Ala Leu Ala Asp Phe Ser 
            20                  25                  30          


Leu Asp Asn Glu Val His Ser Ser Phe Ile His Arg Arg Leu Arg Ser 
        35                  40                  45              


Gln Glu Arg Arg Glu Met Gln Arg Glu Ile Leu Ser Ile Leu Gly Leu 
    50                  55                  60                  


Pro His Arg Pro Arg Pro His Leu Gln Gly Lys His Asn Ser Ala Pro 
65                  70                  75                  80  


Met Phe Met Leu Asp Leu Tyr Asn Ala Met Ala Val Glu Glu Gly Gly 
                85                  90                  95      


Gly Pro Gly Gly Gln Gly Phe Ser Tyr Pro Tyr Lys Ala Val Phe Ser 
            100                 105                 110         


Thr Gln Gly Pro Pro Leu Ala Ser Leu Gln Asp Ser His Phe Leu Thr 
        115                 120                 125             


Asp Ala Asp Met Val Met Ser Phe Val Asn Leu Val Glu His Asp Lys 
    130                 135                 140                 


Glu Phe Phe His Pro Arg Tyr His His Arg Glu Phe Arg Phe Asp Leu 
145                 150                 155                 160 


Ser Lys Ile Pro Glu Gly Glu Ala Val Thr Ala Ala Glu Phe Arg Ile 
                165                 170                 175     


Tyr Lys Asp Tyr Ile Arg Glu Arg Phe Asp Asn Glu Thr Phe Arg Ile 
            180                 185                 190         


Ser Val Tyr Gln Val Leu Gln Glu His Leu Gly Arg Glu Ser Asp Leu 
        195                 200                 205             


Phe Leu Leu Asp Ser Arg Thr Leu Trp Ala Ser Glu Glu Gly Trp Leu 
    210                 215                 220                 


Val Phe Asp Ile Thr Ala Thr Ser Asn His Trp Val Val Asn Pro Arg 
225                 230                 235                 240 


His Asn Leu Gly Leu Gln Leu Ser Val Glu Thr Leu Asp Gly Gln Ser 
                245                 250                 255     


Ile Asn Pro Lys Leu Ala Gly Leu Ile Gly Arg His Gly Pro Gln Asn 
            260                 265                 270         


Lys Gln Pro Phe Met Val Ala Phe Phe Lys Ala Thr Glu Val His Phe 
        275                 280                 285             


Arg Ser Ile Arg Ser Thr Gly Ser Lys Gln Arg Ser Gln Asn Arg Ser 
    290                 295                 300                 


Lys Thr Pro Lys Asn Gln Glu Ala Leu Arg Met Ala Asn Val Ala Glu 
305                 310                 315                 320 


Asn Ser Ser Ser Asp Gln Arg Gln Ala Cys Lys Lys His Glu Leu Tyr 
                325                 330                 335     


Val Ser Phe Arg Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala Pro Glu 
            340                 345                 350         


Gly Tyr Ala Ala Tyr Tyr Cys Glu Gly Glu Cys Ala Phe Pro Leu Asn 
        355                 360                 365             


Ser Tyr Met Asn Ala Thr Asn His Ala Ile Val Gln Thr Leu Val Gly 
    370                 375                 380                 


Val Thr Pro Ser Trp Gly Val Val Thr Trp Ala Gly Gln Ala Ala Gly 
385                 390                 395                 400 


Pro Pro Asp Pro Ala Ala Ser Lys Leu Gly Pro Glu 
                405                 410         


<210>  1506
<211>  297
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1506

Xaa Pro Pro Leu Ala Ser Leu Gln Asp Ser His Phe Leu Thr Asp Ala 
1               5                   10                  15      


Asp Met Val Met Ser Phe Val Asn Leu Val Glu His Asp Lys Glu Phe 
            20                  25                  30          


Phe His Pro Arg Tyr His His Arg Glu Phe Arg Phe Asp Leu Ser Lys 
        35                  40                  45              


Ile Pro Glu Gly Glu Ala Val Thr Ala Ala Glu Phe Arg Ile Tyr Lys 
    50                  55                  60                  


Asp Tyr Ile Arg Glu Arg Phe Asp Asn Glu Thr Phe Arg Ile Ser Val 
65                  70                  75                  80  


Tyr Gln Val Leu Gln Glu His Leu Gly Ser Thr Gly Thr Cys Cys Met 
                85                  90                  95      


Pro Cys Leu Arg Ala Ser Thr Arg Thr Asn Gln Thr Arg Val Pro Ala 
            100                 105                 110         


Leu Trp Lys Leu Thr Phe Gln Gln Arg Arg Gly His Gly Arg Glu Ser 
        115                 120                 125             


Asp Leu Phe Leu Leu Asp Ser Arg Thr Leu Trp Ala Ser Glu Glu Gly 
    130                 135                 140                 


Trp Leu Val Phe Asp Ile Thr Ala Thr Ser Asn His Trp Val Val Asn 
145                 150                 155                 160 


Pro Arg His Asn Leu Gly Leu Gln Leu Ser Val Glu Thr Leu Asp Gly 
                165                 170                 175     


Gln Ser Ile Asn Pro Lys Leu Ala Gly Leu Ile Gly Arg His Gly Pro 
            180                 185                 190         


Gln Asn Lys Gln Pro Phe Met Val Ala Phe Phe Lys Ala Thr Glu Val 
        195                 200                 205             


His Phe Arg Ser Ile Arg Ser Thr Gly Ser Lys Gln Arg Ser Gln Asn 
    210                 215                 220                 


Arg Ser Lys Thr Pro Lys Asn Gln Glu Ala Leu Arg Met Ala Asn Val 
225                 230                 235                 240 


Ala Glu Asn Ser Ser Ser Asp Gln Arg Gln Ala Cys Lys Lys His Glu 
                245                 250                 255     


Leu Tyr Val Ser Phe Arg Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala 
            260                 265                 270         


Pro Glu Gly Tyr Ala Ala Tyr Tyr Cys Glu Gly Glu Cys Ala Phe Pro 
        275                 280                 285             


Leu Asn Ser Tyr Met Asn Ala Thr Asn 
    290                 295         


<210>  1507
<211>  402
<212>  PRT
<213>  Homo Sapiens

<400>  1507

Met Ala Ala Arg Pro Gly Pro Leu Trp Leu Leu Gly Leu Thr Leu Cys 
1               5                   10                  15      


Ala Leu Gly Gly Gly Gly Pro Gly Leu Arg Pro Pro Pro Gly Cys Pro 
            20                  25                  30          


Gln Arg Arg Leu Gly Ala Arg Glu Arg Arg Asp Val Gln Arg Glu Ile 
        35                  40                  45              


Leu Ala Val Leu Gly Leu Pro Gly Arg Pro Arg Pro Arg Ala Pro Pro 
    50                  55                  60                  


Ala Ala Ser Arg Leu Pro Ala Ser Ala Pro Leu Phe Met Leu Asp Leu 
65                  70                  75                  80  


Tyr His Ala Met Ala Gly Asp Asp Asp Glu Asp Gly Ala Pro Ala Glu 
                85                  90                  95      


Gln Arg Leu Gly Arg Ala Asp Leu Val Met Ser Phe Val Asn Met Val 
            100                 105                 110         


Glu Arg Asp Arg Ala Leu Gly His Gln Glu Pro His Trp Lys Glu Phe 
        115                 120                 125             


Arg Phe Asp Leu Thr Gln Ile Pro Ala Gly Glu Ala Val Thr Ala Ala 
    130                 135                 140                 


Glu Phe Arg Ile Tyr Lys Val Pro Ser Ile His Leu Leu Asn Arg Thr 
145                 150                 155                 160 


Leu His Val Ser Met Phe Gln Val Val Gln Glu Gln Ser Asn Arg Glu 
                165                 170                 175     


Ser Asp Leu Phe Phe Leu Asp Leu Gln Thr Leu Arg Ala Gly Asp Glu 
            180                 185                 190         


Gly Trp Leu Val Leu Asp Val Thr Ala Ala Ser Asp Cys Trp Leu Leu 
        195                 200                 205             


Lys Arg His Lys Asp Leu Gly Leu Arg Leu Tyr Val Glu Thr Glu Asp 
    210                 215                 220                 


Gly His Ser Val Asp Pro Gly Leu Ala Gly Leu Leu Gly Gln Arg Ala 
225                 230                 235                 240 


Pro Arg Ser Gln Gln Pro Phe Val Val Thr Phe Phe Arg Ala Ser Pro 
                245                 250                 255     


Ser Pro Ile Arg Thr Pro Arg Ala Val Arg Pro Leu Arg Arg Arg Gln 
            260                 265                 270         


Pro Lys Lys Ser Asn Glu Leu Pro Gln Ala Asn Arg Leu Pro Gly Ile 
        275                 280                 285             


Phe Asp Asp Val Arg Gly Ser His Gly Arg Gln Val Cys Arg Arg His 
    290                 295                 300                 


Glu Leu Tyr Val Ser Phe Gln Asp Leu Gly Trp Leu Asp Trp Val Ile 
305                 310                 315                 320 


Ala Pro Gln Gly Tyr Ser Ala Tyr Tyr Cys Glu Gly Glu Cys Ser Phe 
                325                 330                 335     


Pro Leu Asp Ser Cys Met Asn Ala Thr Asn His Ala Ile Leu Gln Ser 
            340                 345                 350         


Leu Val His Leu Met Lys Pro Asn Ala Val Pro Lys Ala Cys Cys Ala 
        355                 360                 365             


Pro Thr Lys Leu Ser Ala Thr Ser Val Leu Tyr Tyr Asp Ser Ser Asn 
    370                 375                 380                 


Asn Val Ile Leu Arg Lys His Arg Asn Met Val Val Lys Ala Cys Gly 
385                 390                 395                 400 


Cys His 
        


<210>  1508
<211>  402
<212>  PRT
<213>  Homo Sapiens

<400>  1508

Met Thr Ala Leu Pro Gly Pro Leu Trp Leu Leu Gly Leu Ala Leu Cys 
1               5                   10                  15      


Ala Leu Gly Gly Gly Gly Pro Gly Leu Arg Pro Pro Pro Gly Cys Pro 
            20                  25                  30          


Gln Arg Arg Leu Gly Ala Arg Glu Arg Arg Asp Val Gln Arg Glu Ile 
        35                  40                  45              


Leu Ala Val Leu Gly Leu Pro Gly Arg Pro Arg Pro Arg Ala Pro Pro 
    50                  55                  60                  


Ala Ala Ser Arg Leu Pro Ala Ser Ala Pro Leu Phe Met Leu Asp Leu 
65                  70                  75                  80  


Tyr His Ala Met Ala Gly Asp Asp Asp Glu Asp Gly Ala Pro Ala Glu 
                85                  90                  95      


Arg Arg Leu Gly Arg Ala Asp Leu Val Met Ser Phe Val Asn Met Val 
            100                 105                 110         


Glu Arg Asp Arg Ala Leu Gly His Gln Glu Pro His Trp Lys Glu Phe 
        115                 120                 125             


Arg Phe Asp Leu Thr Gln Ile Pro Ala Gly Glu Ala Val Thr Ala Ala 
    130                 135                 140                 


Glu Phe Arg Ile Tyr Lys Val Pro Ser Ile His Leu Leu Asn Arg Thr 
145                 150                 155                 160 


Leu His Val Ser Met Phe Gln Val Val Gln Glu Gln Ser Asn Arg Glu 
                165                 170                 175     


Ser Asp Leu Phe Phe Leu Asp Leu Gln Thr Leu Arg Ala Gly Asp Glu 
            180                 185                 190         


Gly Trp Leu Val Leu Asp Val Thr Ala Ala Ser Asp Cys Trp Leu Leu 
        195                 200                 205             


Lys Arg His Lys Asp Leu Gly Leu Arg Leu Tyr Val Glu Thr Glu Asp 
    210                 215                 220                 


Gly His Ser Val Asp Pro Gly Leu Ala Gly Leu Leu Gly Gln Arg Ala 
225                 230                 235                 240 


Pro Arg Ser Gln Gln Pro Phe Val Val Thr Phe Phe Arg Ala Ser Pro 
                245                 250                 255     


Ser Pro Ile Arg Thr Pro Arg Ala Val Arg Pro Leu Arg Arg Arg Gln 
            260                 265                 270         


Pro Lys Lys Ser Asn Glu Leu Pro Gln Ala Asn Arg Leu Pro Gly Ile 
        275                 280                 285             


Phe Asp Asp Val His Gly Ser His Gly Arg Gln Val Cys Arg Arg His 
    290                 295                 300                 


Glu Leu Tyr Val Ser Phe Gln Asp Leu Gly Trp Leu Asp Trp Val Ile 
305                 310                 315                 320 


Ala Pro Gln Gly Tyr Ser Ala Tyr Tyr Cys Glu Gly Glu Cys Ser Phe 
                325                 330                 335     


Pro Leu Asp Ser Cys Met Asn Ala Thr Asn His Ala Ile Leu Gln Ser 
            340                 345                 350         


Leu Val His Leu Met Met Pro Asp Ala Val Pro Lys Ala Cys Cys Ala 
        355                 360                 365             


Pro Thr Lys Leu Ser Ala Thr Ser Val Leu Tyr Tyr Asp Ser Ser Asn 
    370                 375                 380                 


Asn Val Ile Leu Arg Lys His Arg Asn Met Val Val Lys Ala Cys Gly 
385                 390                 395                 400 


Cys His 
        


<210>  1509
<211>  90
<212>  PRT
<213>  Homo Sapiens

<400>  1509

Met Leu Trp Phe Ser Gly Val Gly Ala Leu Ala Glu Arg Tyr Cys Arg 
1               5                   10                  15      


Arg Ser Pro Gly Ile Thr Cys Cys Val Leu Leu Leu Leu Asn Cys Ser 
            20                  25                  30          


Gly Val Pro Met Ser Leu Ala Ser Ser Phe Leu Thr Gly Ser Val Ala 
        35                  40                  45              


Lys Cys Glu Asn Glu Gly Glu Val Leu Gln Ile Pro Phe Ile Thr Asp 
    50                  55                  60                  


Asn Pro Cys Ile Met Cys Val Cys Leu His Glu Pro Thr Arg Trp Ser 
65                  70                  75                  80  


Asn Leu Thr Gln Asn Pro Gly Phe Tyr Asp 
                85                  90  


<210>  1510
<211>  685
<212>  PRT
<213>  Homo Sapiens

<400>  1510

Met Leu Trp Phe Ser Gly Val Gly Ala Leu Ala Glu Arg Tyr Cys Arg 
1               5                   10                  15      


Arg Ser Pro Gly Ile Thr Cys Cys Val Leu Leu Leu Leu Asn Cys Ser 
            20                  25                  30          


Gly Val Pro Met Ser Leu Ala Ser Ser Phe Leu Thr Gly Ser Val Ala 
        35                  40                  45              


Lys Cys Glu Asn Glu Gly Glu Val Leu Gln Ile Pro Phe Ile Thr Asp 
    50                  55                  60                  


Asn Pro Cys Ile Met Cys Val Cys Leu Asn Lys Glu Val Thr Cys Lys 
65                  70                  75                  80  


Arg Glu Lys Cys Pro Val Leu Ser Arg Asp Cys Ala Leu Ala Ile Lys 
                85                  90                  95      


Gln Arg Gly Ala Cys Cys Glu Gln Cys Lys Gly Cys Thr Tyr Glu Gly 
            100                 105                 110         


Asn Thr Tyr Asn Ser Ser Phe Lys Trp Gln Ser Pro Ala Glu Pro Cys 
        115                 120                 125             


Val Leu Arg Gln Cys Gln Glu Gly Val Val Thr Glu Ser Gly Val Arg 
    130                 135                 140                 


Cys Val Val His Cys Lys Asn Pro Leu Glu His Leu Gly Met Cys Cys 
145                 150                 155                 160 


Pro Thr Cys Pro Gly Cys Val Phe Glu Gly Val Gln Tyr Gln Glu Gly 
                165                 170                 175     


Glu Glu Phe Gln Pro Glu Gly Ser Lys Cys Thr Lys Cys Ser Cys Thr 
            180                 185                 190         


Gly Gly Arg Thr Gln Cys Val Arg Glu Val Cys Pro Ile Leu Ser Cys 
        195                 200                 205             


Pro Gln His Leu Ser His Ile Pro Pro Gly Gln Cys Cys Pro Lys Cys 
    210                 215                 220                 


Leu Gly Gln Arg Lys Val Phe Asp Leu Pro Phe Gly Ser Cys Leu Phe 
225                 230                 235                 240 


Arg Ser Asp Val Tyr Asp Asn Gly Ser Ser Phe Leu Tyr Asp Asn Cys 
                245                 250                 255     


Thr Ala Cys Thr Cys Arg Asp Ser Thr Val Val Cys Lys Arg Lys Cys 
            260                 265                 270         


Ser His Pro Gly Gly Cys Asp Gln Gly Gln Glu Gly Cys Cys Glu Glu 
        275                 280                 285             


Cys Leu Leu Arg Val Pro Pro Glu Asp Ile Lys Val Cys Lys Phe Gly 
    290                 295                 300                 


Asn Lys Ile Phe Gln Asp Gly Glu Met Trp Ser Ser Ile Asn Cys Thr 
305                 310                 315                 320 


Ile Cys Ala Cys Val Lys Gly Arg Thr Glu Cys Arg Asn Lys Gln Cys 
                325                 330                 335     


Ile Pro Ile Ser Ser Cys Pro Gln Gly Lys Ile Leu Asn Arg Lys Gly 
            340                 345                 350         


Cys Cys Pro Ile Cys Thr Glu Lys Pro Gly Val Cys Thr Val Phe Gly 
        355                 360                 365             


Asp Pro His Tyr Asn Thr Phe Asp Gly Arg Thr Phe Asn Phe Gln Gly 
    370                 375                 380                 


Thr Cys Gln Tyr Val Leu Thr Lys Asp Cys Ser Ser Pro Ala Ser Pro 
385                 390                 395                 400 


Phe Gln Val Leu Val Lys Asn Asp Ala Arg Arg Thr Arg Ser Phe Ser 
                405                 410                 415     


Trp Thr Lys Ser Val Glu Leu Val Leu Gly Glu Ser Arg Val Ser Leu 
            420                 425                 430         


Gln Gln His Leu Thr Val Arg Trp Asn Gly Ser Arg Ile Ala Leu Pro 
        435                 440                 445             


Cys Arg Ala Pro His Phe His Ile Asp Leu Asp Gly Tyr Leu Leu Lys 
    450                 455                 460                 


Val Thr Thr Lys Ala Gly Leu Glu Ile Ser Trp Asp Gly Asp Ser Phe 
465                 470                 475                 480 


Val Glu Val Met Ala Ala Pro His Leu Lys Gly Lys Leu Cys Gly Leu 
                485                 490                 495     


Cys Gly Asn Tyr Asn Gly His Lys Arg Asp Asp Leu Ile Gly Gly Asp 
            500                 505                 510         


Gly Asn Phe Lys Phe Asp Val Asp Asp Phe Ala Glu Ser Trp Arg Val 
        515                 520                 525             


Glu Ser Asn Glu Phe Cys Asn Arg Pro Gln Arg Lys Pro Val Pro Glu 
    530                 535                 540                 


Leu Cys Gln Gly Thr Val Lys Val Lys Leu Arg Ala His Arg Glu Cys 
545                 550                 555                 560 


Gln Lys Leu Lys Ser Trp Glu Phe Gln Thr Cys His Ser Thr Val Asp 
                565                 570                 575     


Tyr Ala Thr Phe Tyr Arg Ser Cys Val Thr Asp Met Cys Glu Cys Pro 
            580                 585                 590         


Val His Lys Asn Cys Tyr Cys Glu Ser Phe Leu Ala Tyr Thr Arg Ala 
        595                 600                 605             


Cys Gln Arg Glu Gly Ile Lys Val His Trp Glu Pro Gln Gln Asn Cys 
    610                 615                 620                 


Ala Ala Thr Gln Cys Lys His Gly Ala Val Tyr Asp Thr Cys Gly Pro 
625                 630                 635                 640 


Gly Cys Ile Lys Thr Cys Asp Asn Trp Asn Glu Ile Gly Pro Cys Asn 
                645                 650                 655     


Lys Pro Cys Val Ala Gly Cys His Cys Pro Ala Asn Leu Val Leu His 
            660                 665                 670         


Lys Gly Arg Cys Ile Lys Pro Val Leu Cys Pro Gln Arg 
        675                 680                 685 


<210>  1511
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  1511

Met Leu Trp Phe Ser Gly Val Gly Ala Leu Ala Glu Arg Tyr Cys Arg 
1               5                   10                  15      


Arg Ser Pro Gly Ile Thr Cys Cys Val Leu Leu Leu Leu Asn Cys Ser 
            20                  25                  30          


Gly Val Pro Met Ser Leu Ala Ser Ser Phe Leu Thr Gly Ser Val Ala 
        35                  40                  45              


Lys Cys Glu Asn Glu Gly Glu Val Leu Gln Ile Pro Phe Ile Thr Asp 
    50                  55                  60                  


Asn Pro Cys Ile Met Cys Val Cys Leu Asn Lys Glu Val Thr Cys Lys 
65                  70                  75                  80  


Arg Glu Lys Cys Pro Val Leu Ser Arg Asp Cys Ala Leu Ala Ile Lys 
                85                  90                  95      


Gln Arg Gly Ala Cys Cys Glu Gln Cys Lys Val Leu Val Ser Arg Val 
            100                 105                 110         


Leu Arg Asp Thr Val Leu Phe Thr Leu Lys Tyr Trp Arg Leu Pro Val 
        115                 120                 125             


Phe Trp Leu His Leu 
    130             


<210>  1512
<211>  161
<212>  PRT
<213>  Homo Sapiens

<400>  1512

Met Leu Trp Phe Ser Gly Val Gly Ala Leu Ala Glu Arg Tyr Cys Arg 
1               5                   10                  15      


Arg Ser Pro Gly Ile Thr Cys Cys Val Leu Leu Leu Leu Asn Cys Ser 
            20                  25                  30          


Gly Val Pro Met Ser Leu Ala Ser Ser Phe Leu Thr Gly Ser Val Ala 
        35                  40                  45              


Lys Cys Glu Asn Glu Gly Glu Val Leu Gln Ile Pro Phe Ile Thr Asp 
    50                  55                  60                  


Asn Pro Cys Ile Met Cys Val Cys Leu Val Ala Pro Met Lys Glu Ile 
65                  70                  75                  80  


Pro Ile Thr Ala Pro Ser Asn Gly Arg Ala Arg Leu Ser Leu Val Phe 
                85                  90                  95      


Tyr Ala Ser Ala Arg Arg Ala Leu Ser Gln Ser Leu Gly Cys Ala Val 
            100                 105                 110         


Leu Phe Ile Val Lys Thr Leu Trp Ser Ile Trp Glu Cys Ala Ala Pro 
        115                 120                 125             


His Val Gln Ala Val Cys Leu Arg Val Cys Ser Ile Lys Lys Gly Arg 
    130                 135                 140                 


Asn Phe Ser Gln Lys Glu Ala Asn Val Pro Ser Val Pro Ala Leu Glu 
145                 150                 155                 160 


Ala 
    


<210>  1513
<211>  987
<212>  PRT
<213>  Homo Sapiens

<400>  1513

Met Arg Cys Arg Asn Met Phe Phe Ser Phe Lys Ala Ser Leu Cys Gly 
1               5                   10                  15      


Cys Gly Ala Ala Thr Ala Pro Ser Leu Thr Ala Ile Ser Cys Thr Leu 
            20                  25                  30          


Asn Cys Ser Cys Gln Ser Phe Lys Pro Gly Lys Ile Asn His Arg Gln 
        35                  40                  45              


Cys Asp Gln Cys Lys His Gly Trp Val Ala His Ala Leu Ser Lys Leu 
    50                  55                  60                  


Arg Ile Pro Pro Met Tyr Pro Thr Ser Gln Val Glu Ile Val Gln Ser 
65                  70                  75                  80  


Asn Val Val Phe Asp Ile Ser Ser Leu Met Leu Tyr Gly Thr Gln Ala 
                85                  90                  95      


Ile Pro Val Arg Leu Lys Ile Leu Leu Asp Arg Leu Phe Ser Val Leu 
            100                 105                 110         


Lys Gln Asp Glu Val Leu Gln Ile Leu His Ala Leu Asp Trp Thr Leu 
        115                 120                 125             


Gln Asp Tyr Ile Arg Gly Tyr Val Leu Gln Asp Ala Ser Gly Lys Val 
    130                 135                 140                 


Leu Asp His Trp Ser Ile Met Thr Ser Glu Glu Glu Val Ala Thr Leu 
145                 150                 155                 160 


Gln Gln Phe Leu Arg Phe Gly Glu Thr Lys Ser Ile Val Glu Leu Met 
                165                 170                 175     


Ala Ile Gln Glu Lys Glu Glu Gln Ser Ile Ile Ile Pro Pro Ser Thr 
            180                 185                 190         


Ala Asn Val Asp Ile Arg Ala Phe Ile Glu Ser Cys Ser His Arg Ser 
        195                 200                 205             


Ser Ser Leu Pro Thr Pro Val Asp Lys Gly Asn Pro Ser Ser Ile His 
    210                 215                 220                 


Pro Phe Glu Asn Leu Ile Ser Asn Met Thr Phe Met Leu Pro Phe Gln 
225                 230                 235                 240 


Phe Phe Asn Pro Leu Pro Pro Ala Leu Ile Gly Ser Leu Pro Glu Gln 
                245                 250                 255     


Tyr Met Leu Glu Gln Gly His Asp Gln Ser Gln Asp Pro Lys Gln Glu 
            260                 265                 270         


Val His Gly Pro Phe Pro Asp Ser Ser Phe Leu Thr Ser Ser Ser Thr 
        275                 280                 285             


Pro Phe Gln Val Glu Lys Asp Gln Cys Leu Asn Cys Pro Asp Ala Ile 
    290                 295                 300                 


Thr Lys Lys Glu Asp Ser Thr His Leu Ser Asp Ser Ser Ser Tyr Asn 
305                 310                 315                 320 


Ile Val Thr Lys Phe Glu Arg Thr Gln Leu Ser Pro Glu Ala Lys Val 
                325                 330                 335     


Lys Pro Glu Arg Asn Ser Leu Gly Thr Lys Lys Gly Arg Val Phe Cys 
            340                 345                 350         


Thr Ala Cys Glu Lys Thr Phe Tyr Asp Lys Gly Thr Leu Lys Ile His 
        355                 360                 365             


Tyr Asn Ala Val His Leu Lys Ile Lys His Lys Cys Thr Ile Glu Gly 
    370                 375                 380                 


Cys Asn Met Val Phe Ser Ser Leu Arg Ser Arg Asn Arg His Ser Ala 
385                 390                 395                 400 


Asn Pro Asn Pro Arg Leu His Met Pro Met Asn Arg Asn Asn Arg Asp 
                405                 410                 415     


Lys Asp Leu Arg Asn Ser Leu Asn Leu Ala Ser Ser Glu Asn Tyr Lys 
            420                 425                 430         


Cys Pro Gly Phe Thr Val Thr Ser Pro Asp Cys Arg Pro Pro Pro Ser 
        435                 440                 445             


Tyr Pro Gly Ser Gly Glu Asp Ser Lys Gly Gln Pro Ala Phe Pro Asn 
    450                 455                 460                 


Ile Gly Gln Asn Gly Val Leu Phe Pro Asn Leu Lys Thr Val Gln Pro 
465                 470                 475                 480 


Val Leu Pro Phe Tyr Arg Ser Pro Ala Thr Pro Ala Glu Val Ala Asn 
                485                 490                 495     


Thr Pro Gly Ile Leu Pro Ser Leu Pro Leu Leu Ser Ser Ser Ile Pro 
            500                 505                 510         


Glu Gln Leu Ile Ser Asn Glu Met Pro Phe Asp Ala Leu Pro Lys Lys 
        515                 520                 525             


Lys Ser Arg Lys Ser Ser Met Pro Ile Lys Ile Glu Lys Glu Ala Val 
    530                 535                 540                 


Glu Ile Ala Asn Glu Lys Arg His Asn Leu Ser Ser Asp Glu Asp Met 
545                 550                 555                 560 


Pro Leu Gln Val Val Ser Glu Asp Glu Gln Glu Ala Cys Ser Pro Gln 
                565                 570                 575     


Ser His Arg Val Ser Glu Glu Gln His Val Gln Ser Gly Gly Leu Gly 
            580                 585                 590         


Lys Pro Phe Pro Glu Gly Glu Arg Pro Cys His Arg Glu Ser Val Ile 
        595                 600                 605             


Glu Ser Ser Gly Ala Ile Ser Gln Thr Pro Glu Gln Ala Thr His Asn 
    610                 615                 620                 


Ser Glu Arg Glu Thr Glu Gln Thr Pro Ala Leu Ile Met Val Pro Arg 
625                 630                 635                 640 


Glu Val Glu Asp Gly Gly His Glu His Tyr Phe Thr Pro Gly Met Glu 
                645                 650                 655     


Pro Gln Val Pro Phe Ser Asp Tyr Met Glu Leu Gln Gln Arg Leu Leu 
            660                 665                 670         


Ala Gly Gly Leu Phe Ser Ala Leu Ser Asn Arg Gly Met Ala Phe Pro 
        675                 680                 685             


Cys Leu Glu Asp Ser Lys Glu Leu Glu His Val Gly Gln His Ala Leu 
    690                 695                 700                 


Ala Arg Gln Ile Glu Glu Asn Arg Phe Gln Cys Asp Ile Cys Lys Lys 
705                 710                 715                 720 


Thr Phe Lys Asn Ala Cys Ser Val Lys Ile His His Lys Asn Met His 
                725                 730                 735     


Val Lys Glu Met His Thr Cys Thr Val Glu Gly Cys Asn Ala Thr Phe 
            740                 745                 750         


Pro Ser Arg Arg Ser Arg Asp Arg His Ser Ser Asn Leu Asn Leu His 
        755                 760                 765             


Gln Lys Ala Leu Ser Gln Glu Ala Leu Glu Ser Ser Glu Asp His Phe 
    770                 775                 780                 


Arg Ala Ala Tyr Leu Leu Lys Asp Val Ala Lys Glu Ala Tyr Gln Asp 
785                 790                 795                 800 


Val Ala Phe Thr Gln Gln Ala Ser Gln Thr Ser Val Ile Phe Lys Gly 
                805                 810                 815     


Thr Ser Arg Met Gly Ser Leu Val Tyr Pro Ile Thr Gln Val His Ser 
            820                 825                 830         


Ala Ser Leu Glu Ser Tyr Asn Ser Gly Pro Leu Ser Glu Gly Thr Ile 
        835                 840                 845             


Leu Asp Leu Ser Thr Thr Ser Ser Met Lys Ser Glu Ser Ser Ser His 
    850                 855                 860                 


Ser Ser Trp Asp Ser Asp Gly Val Ser Glu Glu Gly Thr Val Leu Met 
865                 870                 875                 880 


Glu Asp Ser Asp Gly Asn Cys Glu Gly Ser Ser Leu Val Pro Gly Glu 
                885                 890                 895     


Asp Glu Tyr Pro Ile Cys Val Leu Met Glu Lys Ala Asp Gln Ser Leu 
            900                 905                 910         


Ala Ser Leu Pro Ser Gly Leu Pro Ile Thr Cys His Leu Cys Gln Lys 
        915                 920                 925             


Thr Tyr Ser Asn Lys Gly Thr Phe Arg Ala His Tyr Lys Thr Val His 
    930                 935                 940                 


Leu Arg Gln Leu His Lys Cys Lys Val Pro Gly Cys Asn Thr Met Phe 
945                 950                 955                 960 


Ser Ser Val Arg Ser Arg Asn Arg His Ser Gln Asn Pro Asn Leu His 
                965                 970                 975     


Lys Ser Leu Ala Ser Ser Pro Ser His Leu Gln 
            980                 985         


<210>  1514
<211>  994
<212>  PRT
<213>  Homo Sapiens

<400>  1514

Met Arg Arg Arg Pro Pro Ser Arg Gly Gly Arg Gly Ala Ala Arg Ala 
1               5                   10                  15      


Arg Glu Thr Arg Arg Gln Pro Arg His Arg Ser Gly Arg Arg Met Ala 
            20                  25                  30          


Glu Ala Ile Ser Cys Thr Leu Asn Cys Ser Cys Gln Ser Phe Lys Pro 
        35                  40                  45              


Gly Lys Ile Asn His Arg Gln Cys Asp Gln Cys Lys His Gly Trp Val 
    50                  55                  60                  


Ala His Ala Leu Ser Lys Leu Arg Ile Pro Pro Met Tyr Pro Thr Ser 
65                  70                  75                  80  


Gln Val Glu Ile Val Gln Ser Asn Val Val Phe Asp Ile Ser Ser Leu 
                85                  90                  95      


Met Leu Tyr Gly Thr Gln Ala Ile Pro Val Arg Leu Lys Ile Leu Leu 
            100                 105                 110         


Asp Arg Leu Phe Ser Val Leu Lys Gln Asp Glu Val Leu Gln Ile Leu 
        115                 120                 125             


His Ala Leu Asp Trp Thr Leu Gln Asp Tyr Ile Arg Gly Tyr Val Leu 
    130                 135                 140                 


Gln Asp Ala Ser Gly Lys Val Leu Asp His Trp Ser Ile Met Thr Ser 
145                 150                 155                 160 


Glu Glu Glu Val Ala Thr Leu Gln Gln Phe Leu Arg Phe Gly Glu Thr 
                165                 170                 175     


Lys Ser Ile Val Glu Leu Met Ala Ile Gln Glu Lys Glu Glu Gln Ser 
            180                 185                 190         


Ile Ile Ile Pro Pro Ser Thr Ala Asn Val Asp Ile Arg Ala Phe Ile 
        195                 200                 205             


Glu Ser Cys Ser His Arg Ser Ser Ser Leu Pro Thr Pro Val Asp Lys 
    210                 215                 220                 


Gly Asn Pro Ser Ser Ile His Pro Phe Glu Asn Leu Ile Ser Asn Met 
225                 230                 235                 240 


Thr Phe Met Leu Pro Phe Gln Phe Phe Asn Pro Leu Pro Pro Ala Leu 
                245                 250                 255     


Ile Gly Ser Leu Pro Glu Gln Tyr Met Leu Glu Gln Gly His Asp Gln 
            260                 265                 270         


Ser Gln Asp Pro Lys Gln Glu Val His Gly Pro Phe Pro Asp Ser Ser 
        275                 280                 285             


Phe Leu Thr Ser Ser Ser Thr Pro Phe Gln Val Glu Lys Asp Gln Cys 
    290                 295                 300                 


Leu Asn Cys Pro Asp Ala Ile Thr Lys Lys Glu Asp Ser Thr His Leu 
305                 310                 315                 320 


Ser Asp Ser Ser Ser Tyr Asn Ile Val Thr Lys Phe Glu Arg Thr Gln 
                325                 330                 335     


Leu Ser Pro Glu Ala Lys Val Lys Pro Glu Arg Asn Ser Leu Gly Thr 
            340                 345                 350         


Lys Lys Gly Arg Val Phe Cys Thr Ala Cys Glu Lys Thr Phe Tyr Asp 
        355                 360                 365             


Lys Gly Thr Leu Lys Ile His Tyr Asn Ala Val His Leu Lys Ile Lys 
    370                 375                 380                 


His Lys Cys Thr Ile Glu Gly Cys Asn Met Val Phe Ser Ser Leu Arg 
385                 390                 395                 400 


Ser Arg Asn Arg His Ser Ala Asn Pro Asn Pro Arg Leu His Met Pro 
                405                 410                 415     


Met Asn Arg Asn Asn Arg Asp Lys Asp Leu Arg Asn Ser Leu Asn Leu 
            420                 425                 430         


Ala Ser Ser Glu Asn Tyr Lys Cys Pro Gly Phe Thr Val Thr Ser Pro 
        435                 440                 445             


Asp Cys Arg Pro Pro Pro Ser Tyr Pro Gly Ser Gly Glu Asp Ser Lys 
    450                 455                 460                 


Gly Gln Pro Ala Phe Pro Asn Ile Gly Gln Asn Gly Val Leu Phe Pro 
465                 470                 475                 480 


Asn Leu Lys Thr Val Gln Pro Val Leu Pro Phe Tyr Arg Ser Pro Ala 
                485                 490                 495     


Thr Pro Ala Glu Val Ala Asn Thr Pro Gly Ile Leu Pro Ser Leu Pro 
            500                 505                 510         


Leu Leu Ser Ser Ser Ile Pro Glu Gln Leu Ile Ser Asn Glu Met Pro 
        515                 520                 525             


Phe Asp Ala Leu Pro Lys Lys Lys Ser Arg Lys Ser Ser Met Pro Ile 
    530                 535                 540                 


Lys Ile Glu Lys Glu Ala Val Glu Ile Ala Asn Glu Lys Arg His Asn 
545                 550                 555                 560 


Leu Ser Ser Asp Glu Asp Met Pro Leu Gln Val Val Ser Glu Asp Glu 
                565                 570                 575     


Gln Glu Ala Cys Ser Pro Gln Ser His Arg Val Ser Glu Glu Gln His 
            580                 585                 590         


Val Gln Ser Gly Gly Leu Gly Lys Pro Phe Pro Glu Gly Glu Arg Pro 
        595                 600                 605             


Cys His Arg Glu Ser Val Ile Glu Ser Ser Gly Ala Ile Ser Gln Thr 
    610                 615                 620                 


Pro Glu Gln Ala Thr His Asn Ser Glu Arg Glu Thr Glu Gln Thr Pro 
625                 630                 635                 640 


Ala Leu Ile Met Val Pro Arg Glu Val Glu Asp Gly Gly His Glu His 
                645                 650                 655     


Tyr Phe Thr Pro Gly Met Glu Pro Gln Val Pro Phe Ser Asp Tyr Met 
            660                 665                 670         


Glu Leu Gln Gln Arg Leu Leu Ala Gly Gly Leu Phe Ser Ala Leu Ser 
        675                 680                 685             


Asn Arg Gly Met Ala Phe Pro Cys Leu Glu Asp Ser Lys Glu Leu Glu 
    690                 695                 700                 


His Val Gly Gln His Ala Leu Ala Arg Gln Ile Glu Glu Asn Arg Phe 
705                 710                 715                 720 


Gln Cys Asp Ile Cys Lys Lys Thr Phe Lys Asn Ala Cys Ser Val Lys 
                725                 730                 735     


Ile His His Lys Asn Met His Val Lys Glu Met His Thr Cys Thr Val 
            740                 745                 750         


Glu Gly Cys Asn Ala Thr Phe Pro Ser Arg Arg Ser Arg Asp Arg His 
        755                 760                 765             


Ser Ser Asn Leu Asn Leu His Gln Lys Ala Leu Ser Gln Glu Ala Leu 
    770                 775                 780                 


Glu Ser Ser Glu Asp His Phe Arg Ala Ala Tyr Leu Leu Lys Asp Val 
785                 790                 795                 800 


Ala Lys Glu Ala Tyr Gln Asp Val Ala Phe Thr Gln Gln Ala Ser Gln 
                805                 810                 815     


Thr Ser Val Ile Phe Lys Gly Thr Ser Arg Met Gly Ser Leu Val Tyr 
            820                 825                 830         


Pro Ile Thr Gln Val His Ser Ala Ser Leu Glu Ser Tyr Asn Ser Gly 
        835                 840                 845             


Pro Leu Ser Glu Gly Thr Ile Leu Asp Leu Ser Thr Thr Ser Ser Met 
    850                 855                 860                 


Lys Ser Glu Ser Ser Ser His Ser Ser Trp Asp Ser Asp Gly Val Ser 
865                 870                 875                 880 


Glu Glu Gly Thr Val Leu Met Glu Asp Ser Asp Gly Asn Cys Glu Gly 
                885                 890                 895     


Ser Ser Leu Val Pro Gly Glu Asp Glu Tyr Pro Ile Cys Val Leu Met 
            900                 905                 910         


Glu Lys Ala Asp Gln Ser Leu Ala Ser Leu Pro Ser Gly Leu Pro Ile 
        915                 920                 925             


Thr Cys His Leu Cys Gln Lys Thr Tyr Ser Asn Lys Gly Thr Phe Arg 
    930                 935                 940                 


Ala His Tyr Lys Thr Val His Leu Arg Gln Leu His Lys Cys Lys Val 
945                 950                 955                 960 


Pro Gly Cys Asn Thr Met Phe Ser Ser Val Arg Ser Arg Asn Arg His 
                965                 970                 975     


Ser Gln Asn Pro Asn Leu His Lys Ser Leu Ala Ser Ser Pro Ser His 
            980                 985                 990         


Leu Gln 
        


<210>  1515
<211>  22
<212>  PRT
<213>  Homo Sapiens

<400>  1515

Met Leu Arg Gly Thr Met Thr Ala Trp Arg Gly Met Arg Pro Glu Val 
1               5                   10                  15      


Thr Leu Ala Cys Leu Leu 
            20          


<210>  1516
<211>  32
<212>  PRT
<213>  Homo Sapiens

<400>  1516

Met Leu Arg Gly Thr Met Thr Ala Trp Arg Gly Met Arg Pro Glu Val 
1               5                   10                  15      


Thr Leu Ala Cys Leu Leu Leu Ala Thr Ala Gly Cys Phe Ala Asp Leu 
            20                  25                  30          


<210>  1517
<211>  85
<212>  PRT
<213>  Homo Sapiens

<400>  1517

Met Leu Arg Gly Thr Met Thr Ala Trp Arg Gly Met Arg Pro Glu Val 
1               5                   10                  15      


Thr Leu Ala Cys Leu Leu Leu Ala Thr Ala Gly Cys Phe Ala Asp Leu 
            20                  25                  30          


Asn Glu Val Pro Gln Val Thr Val Gln Pro Ala Ser Thr Val Gln Lys 
        35                  40                  45              


Pro Gly Gly Thr Val Ile Leu Gly Cys Val Val Glu Pro Pro Arg Met 
    50                  55                  60                  


Asn Val Thr Trp Arg Leu Asn Gly Lys Glu Leu Asn Gly Ser Asp Asp 
65                  70                  75                  80  


Ala Leu Gly Val Leu 
                85  


<210>  1518
<211>  1115
<212>  PRT
<213>  Homo Sapiens

<400>  1518

Met Leu Arg Gly Thr Met Thr Ala Trp Arg Gly Met Arg Pro Glu Val 
1               5                   10                  15      


Thr Leu Ala Cys Leu Leu Leu Ala Thr Ala Gly Cys Phe Ala Asp Leu 
            20                  25                  30          


Asn Glu Val Pro Gln Val Thr Val Gln Pro Ala Ser Thr Val Gln Lys 
        35                  40                  45              


Pro Gly Gly Thr Val Ile Leu Gly Cys Val Val Glu Pro Pro Arg Met 
    50                  55                  60                  


Asn Val Thr Trp Arg Leu Asn Gly Lys Glu Leu Asn Gly Ser Asp Asp 
65                  70                  75                  80  


Ala Leu Gly Val Leu Ile Thr His Gly Thr Leu Val Ile Thr Ala Leu 
                85                  90                  95      


Asn Asn His Thr Val Gly Arg Tyr Gln Cys Val Ala Arg Met Pro Ala 
            100                 105                 110         


Gly Ala Val Ala Ser Val Pro Ala Thr Val Thr Leu Ala Asn Leu Gln 
        115                 120                 125             


Asp Phe Lys Leu Asp Val Gln His Val Ile Glu Val Asp Glu Gly Asn 
    130                 135                 140                 


Thr Ala Val Ile Ala Cys His Leu Pro Glu Ser His Pro Lys Ala Gln 
145                 150                 155                 160 


Val Arg Tyr Ser Val Lys Gln Glu Trp Leu Glu Ala Ser Arg Gly Asn 
                165                 170                 175     


Tyr Leu Ile Met Pro Ser Gly Asn Leu Gln Ile Val Asn Ala Ser Gln 
            180                 185                 190         


Glu Asp Glu Gly Met Tyr Lys Cys Ala Ala Tyr Asn Pro Val Thr Gln 
        195                 200                 205             


Glu Val Lys Thr Ser Gly Ser Ser Asp Arg Leu Arg Val Arg Arg Ser 
    210                 215                 220                 


Thr Ala Glu Ala Ala Arg Ile Ile Tyr Pro Pro Glu Ala Gln Thr Ile 
225                 230                 235                 240 


Ile Val Thr Lys Gly Gln Ser Leu Ile Leu Glu Cys Val Ala Ser Gly 
                245                 250                 255     


Ile Pro Pro Pro Arg Val Thr Trp Ala Lys Asp Gly Ser Ser Val Thr 
            260                 265                 270         


Gly Tyr Asn Lys Thr Arg Phe Leu Leu Ser Asn Leu Leu Ile Asp Thr 
        275                 280                 285             


Thr Ser Glu Glu Asp Ser Gly Thr Tyr Arg Cys Met Ala Asp Asn Gly 
    290                 295                 300                 


Val Gly Gln Pro Gly Ala Ala Val Ile Leu Tyr Asn Val Gln Val Phe 
305                 310                 315                 320 


Glu Pro Pro Glu Val Thr Met Glu Leu Ser Gln Leu Val Ile Pro Trp 
                325                 330                 335     


Gly Gln Ser Ala Lys Leu Thr Cys Glu Val Arg Gly Asn Pro Pro Pro 
            340                 345                 350         


Ser Val Leu Trp Leu Arg Asn Ala Val Pro Leu Ile Ser Ser Gln Arg 
        355                 360                 365             


Leu Arg Leu Ser Arg Arg Ala Leu Arg Val Leu Ser Met Gly Pro Glu 
    370                 375                 380                 


Asp Glu Gly Val Tyr Gln Cys Met Ala Glu Asn Glu Val Gly Ser Ala 
385                 390                 395                 400 


His Ala Val Val Gln Leu Arg Thr Ser Arg Pro Ser Ile Thr Pro Arg 
                405                 410                 415     


Leu Trp Gln Asp Ala Glu Leu Ala Thr Gly Thr Pro Pro Val Ser Pro 
            420                 425                 430         


Ser Lys Leu Gly Asn Pro Glu Gln Met Leu Arg Gly Gln Pro Ala Leu 
        435                 440                 445             


Pro Arg Pro Pro Thr Ser Val Gly Pro Ala Ser Pro Gln Cys Pro Gly 
    450                 455                 460                 


Glu Lys Gly Gln Gly Ala Pro Ala Glu Ala Pro Ile Ile Leu Ser Ser 
465                 470                 475                 480 


Pro Arg Thr Ser Lys Thr Asp Ser Tyr Glu Leu Val Trp Arg Pro Arg 
                485                 490                 495     


His Glu Gly Ser Gly Arg Ala Pro Ile Leu Tyr Tyr Val Val Lys His 
            500                 505                 510         


Arg Lys Gln Val Thr Asn Ser Ser Asp Asp Trp Thr Ile Ser Gly Ile 
        515                 520                 525             


Pro Ala Asn Gln His Arg Leu Thr Leu Thr Arg Leu Asp Pro Gly Ser 
    530                 535                 540                 


Leu Tyr Glu Val Glu Met Ala Ala Tyr Asn Cys Ala Gly Glu Gly Gln 
545                 550                 555                 560 


Thr Ala Met Val Thr Phe Arg Thr Gly Arg Arg Pro Lys Pro Glu Ile 
                565                 570                 575     


Met Ala Ser Lys Glu Gln Gln Ile Gln Arg Asp Asp Pro Gly Ala Ser 
            580                 585                 590         


Pro Gln Ser Ser Ser Gln Pro Asp His Gly Arg Leu Ser Pro Pro Glu 
        595                 600                 605             


Ala Pro Asp Arg Pro Thr Ile Ser Thr Ala Ser Glu Thr Ser Val Tyr 
    610                 615                 620                 


Val Thr Trp Ile Pro Arg Gly Asn Gly Gly Phe Pro Ile Gln Ser Phe 
625                 630                 635                 640 


Arg Val Glu Tyr Lys Lys Leu Lys Lys Val Gly Asp Trp Ile Leu Ala 
                645                 650                 655     


Thr Ser Ala Ile Pro Pro Ser Arg Leu Ser Val Glu Ile Thr Gly Leu 
            660                 665                 670         


Glu Lys Gly Thr Ser Tyr Lys Phe Arg Val Arg Ala Leu Asn Met Leu 
        675                 680                 685             


Gly Glu Ser Glu Pro Ser Ala Pro Ser Arg Pro Tyr Val Val Ser Gly 
    690                 695                 700                 


Tyr Ser Gly Arg Val Tyr Glu Arg Pro Val Ala Gly Pro Tyr Ile Thr 
705                 710                 715                 720 


Phe Thr Asp Ala Val Asn Glu Thr Thr Ile Met Leu Lys Trp Met Tyr 
                725                 730                 735     


Ile Pro Ala Ser Asn Asn Asn Thr Pro Ile His Gly Phe Tyr Ile Tyr 
            740                 745                 750         


Tyr Arg Pro Thr Asp Ser Asp Asn Asp Ser Asp Tyr Lys Lys Asp Met 
        755                 760                 765             


Val Glu Gly Asp Lys Tyr Trp His Ser Ile Ser His Leu Gln Pro Glu 
    770                 775                 780                 


Thr Ser Tyr Asp Ile Lys Met Gln Cys Phe Asn Glu Gly Gly Glu Ser 
785                 790                 795                 800 


Glu Phe Ser Asn Val Met Ile Cys Glu Thr Lys Ala Arg Lys Ser Ser 
                805                 810                 815     


Gly Gln Pro Gly Arg Leu Pro Pro Pro Thr Leu Ala Pro Pro Gln Pro 
            820                 825                 830         


Pro Leu Pro Glu Thr Ile Glu Arg Pro Val Gly Thr Gly Ala Met Val 
        835                 840                 845             


Ala Arg Ser Ser Asp Leu Pro Tyr Leu Ile Val Gly Val Val Leu Gly 
    850                 855                 860                 


Ser Ile Val Leu Ile Ile Val Thr Phe Ile Pro Phe Cys Leu Trp Arg 
865                 870                 875                 880 


Ala Trp Ser Lys Gln Lys His Thr Thr Asp Leu Gly Phe Pro Arg Ser 
                885                 890                 895     


Ala Leu Pro Pro Ser Cys Pro Tyr Thr Met Val Pro Leu Gly Gly Leu 
            900                 905                 910         


Pro Gly His Gln Ala Ser Gly Gln Pro Tyr Leu Ser Gly Ile Ser Gly 
        915                 920                 925             


Arg Ala Cys Ala Asn Gly Ile His Met Asn Arg Gly Cys Pro Ser Ala 
    930                 935                 940                 


Ala Val Gly Tyr Pro Gly Met Lys Pro Gln Gln His Cys Pro Gly Glu 
945                 950                 955                 960 


Leu Gln Gln Gln Ser Asp Thr Ser Ser Leu Leu Arg Gln Thr His Leu 
                965                 970                 975     


Gly Asn Gly Tyr Asp Pro Gln Ser His Gln Ile Thr Arg Gly Pro Lys 
            980                 985                 990         


Ser Ser Pro Asp Glu Gly Ser Phe  Leu Tyr Thr Leu Pro  Asp Asp Ser 
        995                 1000                 1005             


Thr His  Gln Leu Leu Gln Pro  His His Asp Cys Cys  Gln Arg Gln 
    1010                 1015                 1020             


Glu Gln  Pro Ala Ala Val Gly  Gln Ser Gly Val Arg  Arg Ala Pro 
    1025                 1030                 1035             


Asp Ser  Pro Val Leu Glu Ala  Val Trp Asp Pro Pro  Phe His Ser 
    1040                 1045                 1050             


Gly Pro  Pro Cys Cys Leu Gly  Leu Val Pro Val Glu  Glu Val Asp 
    1055                 1060                 1065             


Ser Pro  Asp Ser Cys Gln Val  Ser Gly Gly Asp Trp  Cys Pro Gln 
    1070                 1075                 1080             


His Pro  Val Gly Ala Tyr Val  Gly Gln Glu Pro Gly  Met Gln Leu 
    1085                 1090                 1095             


Ser Pro  Gly Pro Leu Val Arg  Val Ser Phe Glu Thr  Pro Pro Leu 
    1100                 1105                 1110             


Thr Ile  
    1115 


<210>  1519
<211>  1114
<212>  PRT
<213>  Homo Sapiens

<400>  1519

Met Leu Arg Gly Thr Met Thr Ala Trp Arg Gly Met Arg Pro Glu Val 
1               5                   10                  15      


Thr Leu Ala Cys Leu Leu Leu Ala Thr Ala Gly Cys Phe Ala Asp Leu 
            20                  25                  30          


Asn Glu Val Pro Gln Val Thr Val Gln Pro Ala Ser Thr Val Gln Lys 
        35                  40                  45              


Pro Gly Gly Thr Val Ile Leu Gly Cys Val Val Glu Pro Pro Arg Met 
    50                  55                  60                  


Asn Val Thr Trp Arg Leu Asn Gly Lys Glu Leu Asn Gly Ser Asp Asp 
65                  70                  75                  80  


Ala Leu Gly Val Leu Ile Thr His Gly Thr Leu Val Ile Thr Ala Leu 
                85                  90                  95      


Asn Asn His Thr Val Gly Arg Tyr Gln Cys Val Ala Arg Met Pro Ala 
            100                 105                 110         


Gly Ala Val Ala Ser Val Pro Ala Thr Val Thr Leu Ala Asn Leu Gln 
        115                 120                 125             


Asp Phe Lys Leu Asp Val Gln His Val Ile Glu Val Asp Glu Gly Asn 
    130                 135                 140                 


Thr Ala Val Ile Ala Cys His Leu Pro Glu Ser His Pro Lys Ala Gln 
145                 150                 155                 160 


Val Arg Tyr Ser Val Lys Gln Glu Trp Leu Glu Ala Ser Arg Gly Asn 
                165                 170                 175     


Tyr Leu Ile Met Pro Ser Gly Asn Leu Gln Ile Val Asn Ala Ser Gln 
            180                 185                 190         


Glu Asp Glu Gly Met Tyr Lys Cys Ala Ala Tyr Asn Pro Val Thr Gln 
        195                 200                 205             


Glu Val Lys Thr Ser Gly Ser Ser Asp Arg Leu Arg Val Arg Arg Ser 
    210                 215                 220                 


Thr Ala Glu Ala Ala Arg Ile Ile Tyr Pro Pro Glu Ala Gln Thr Ile 
225                 230                 235                 240 


Ile Val Thr Lys Gly Gln Ser Leu Ile Leu Glu Cys Val Ala Ser Gly 
                245                 250                 255     


Ile Pro Pro Pro Arg Val Thr Trp Ala Lys Asp Gly Ser Ser Val Thr 
            260                 265                 270         


Gly Tyr Asn Lys Thr Arg Phe Leu Leu Ser Asn Leu Leu Ile Asp Thr 
        275                 280                 285             


Thr Ser Glu Glu Asp Ser Gly Thr Tyr Arg Cys Met Ala Asp Asn Gly 
    290                 295                 300                 


Val Gly Gln Pro Gly Ala Ala Val Ile Leu Tyr Asn Val Gln Val Phe 
305                 310                 315                 320 


Glu Pro Pro Glu Val Thr Met Glu Leu Ser Gln Leu Val Ile Pro Trp 
                325                 330                 335     


Gly Gln Ser Ala Lys Leu Thr Cys Glu Val Arg Gly Asn Pro Pro Pro 
            340                 345                 350         


Ser Val Leu Trp Leu Arg Asn Ala Val Pro Leu Ile Ser Ser Gln Arg 
        355                 360                 365             


Leu Arg Leu Ser Arg Arg Ala Leu Arg Val Leu Ser Met Gly Pro Glu 
    370                 375                 380                 


Asp Glu Gly Val Tyr Gln Cys Met Ala Glu Asn Glu Val Gly Ser Ala 
385                 390                 395                 400 


His Ala Val Val Gln Leu Arg Thr Ser Arg Pro Ser Ile Thr Pro Arg 
                405                 410                 415     


Leu Trp Gln Asp Ala Glu Leu Ala Thr Gly Thr Pro Pro Val Ser Pro 
            420                 425                 430         


Ser Lys Leu Gly Asn Pro Glu Gln Met Leu Arg Gly Gln Pro Ala Leu 
        435                 440                 445             


Pro Arg Pro Pro Thr Ser Val Gly Pro Ala Ser Pro Gln Cys Pro Gly 
    450                 455                 460                 


Glu Lys Gly Gln Gly Ala Pro Ala Glu Ala Pro Ile Ile Leu Ser Ser 
465                 470                 475                 480 


Pro Arg Thr Ser Lys Thr Asp Ser Tyr Glu Leu Val Trp Arg Pro Arg 
                485                 490                 495     


His Glu Gly Ser Gly Arg Ala Pro Ile Leu Tyr Tyr Val Val Lys His 
            500                 505                 510         


Arg Lys Val Thr Asn Ser Ser Asp Asp Trp Thr Ile Ser Gly Ile Pro 
        515                 520                 525             


Ala Asn Gln His Arg Leu Thr Leu Thr Arg Leu Asp Pro Gly Ser Leu 
    530                 535                 540                 


Tyr Glu Val Glu Met Ala Ala Tyr Asn Cys Ala Gly Glu Gly Gln Thr 
545                 550                 555                 560 


Ala Met Val Thr Phe Arg Thr Gly Arg Arg Pro Lys Pro Glu Ile Met 
                565                 570                 575     


Ala Ser Lys Glu Gln Gln Ile Gln Arg Asp Asp Pro Gly Ala Ser Pro 
            580                 585                 590         


Gln Ser Ser Ser Gln Pro Asp His Gly Arg Leu Ser Pro Pro Glu Ala 
        595                 600                 605             


Pro Asp Arg Pro Thr Ile Ser Thr Ala Ser Glu Thr Ser Val Tyr Val 
    610                 615                 620                 


Thr Trp Ile Pro Arg Gly Asn Gly Gly Phe Pro Ile Gln Ser Phe Arg 
625                 630                 635                 640 


Val Glu Tyr Lys Lys Leu Lys Lys Val Gly Asp Trp Ile Leu Ala Thr 
                645                 650                 655     


Ser Ala Ile Pro Pro Ser Arg Leu Ser Val Glu Ile Thr Gly Leu Glu 
            660                 665                 670         


Lys Gly Thr Ser Tyr Lys Phe Arg Val Arg Ala Leu Asn Met Leu Gly 
        675                 680                 685             


Glu Ser Glu Pro Ser Ala Pro Ser Arg Pro Tyr Val Val Ser Gly Tyr 
    690                 695                 700                 


Ser Gly Arg Val Tyr Glu Arg Pro Val Ala Gly Pro Tyr Ile Thr Phe 
705                 710                 715                 720 


Thr Asp Ala Val Asn Glu Thr Thr Ile Met Leu Lys Trp Met Tyr Ile 
                725                 730                 735     


Pro Ala Ser Asn Asn Asn Thr Pro Ile His Gly Phe Tyr Ile Tyr Tyr 
            740                 745                 750         


Arg Pro Thr Asp Ser Asp Asn Asp Ser Asp Tyr Lys Lys Asp Met Val 
        755                 760                 765             


Glu Gly Asp Lys Tyr Trp His Ser Ile Ser His Leu Gln Pro Glu Thr 
    770                 775                 780                 


Ser Tyr Asp Ile Lys Met Gln Cys Phe Asn Glu Gly Gly Glu Ser Glu 
785                 790                 795                 800 


Phe Ser Asn Val Met Ile Cys Glu Thr Lys Ala Arg Lys Ser Ser Gly 
                805                 810                 815     


Gln Pro Gly Arg Leu Pro Pro Pro Thr Leu Ala Pro Pro Gln Pro Pro 
            820                 825                 830         


Leu Pro Glu Thr Ile Glu Arg Pro Val Gly Thr Gly Ala Met Val Ala 
        835                 840                 845             


Arg Ser Ser Asp Leu Pro Tyr Leu Ile Val Gly Val Val Leu Gly Ser 
    850                 855                 860                 


Ile Val Leu Ile Ile Val Thr Phe Ile Pro Phe Cys Leu Trp Arg Ala 
865                 870                 875                 880 


Trp Ser Lys Gln Lys His Thr Thr Asp Leu Gly Phe Pro Arg Ser Ala 
                885                 890                 895     


Leu Pro Pro Ser Cys Pro Tyr Thr Met Val Pro Leu Gly Gly Leu Pro 
            900                 905                 910         


Gly His Gln Ala Ser Gly Gln Pro Tyr Leu Ser Gly Ile Ser Gly Arg 
        915                 920                 925             


Ala Cys Ala Asn Gly Ile His Met Asn Arg Gly Cys Pro Ser Ala Ala 
    930                 935                 940                 


Val Gly Tyr Pro Gly Met Lys Pro Gln Gln His Cys Pro Gly Glu Leu 
945                 950                 955                 960 


Gln Gln Gln Ser Asp Thr Ser Ser Leu Leu Arg Gln Thr His Leu Gly 
                965                 970                 975     


Asn Gly Tyr Asp Pro Gln Ser His Gln Ile Thr Arg Gly Pro Lys Ser 
            980                 985                 990         


Ser Pro Asp Glu Gly Ser Phe Leu  Tyr Thr Leu Pro Asp  Asp Ser Thr 
        995                 1000                 1005             


His Gln  Leu Leu Gln Pro His  His Asp Cys Cys Gln  Arg Gln Glu 
    1010                 1015                 1020             


Gln Pro  Ala Ala Val Gly Gln  Ser Gly Val Arg Arg  Ala Pro Asp 
    1025                 1030                 1035             


Ser Pro  Val Leu Glu Ala Val  Trp Asp Pro Pro Phe  His Ser Gly 
    1040                 1045                 1050             


Pro Pro  Cys Cys Leu Gly Leu  Val Pro Val Glu Glu  Val Asp Ser 
    1055                 1060                 1065             


Pro Asp  Ser Cys Gln Val Ser  Gly Gly Asp Trp Cys  Pro Gln His 
    1070                 1075                 1080             


Pro Val  Gly Ala Tyr Val Gly  Gln Glu Pro Gly Met  Gln Leu Ser 
    1085                 1090                 1095             


Pro Gly  Pro Leu Val Arg Val  Ser Phe Glu Thr Pro  Pro Leu Thr 
    1100                 1105                 1110             


Ile 
    


<210>  1520
<211>  1114
<212>  PRT
<213>  Homo Sapiens

<400>  1520

Met Leu Arg Gly Thr Met Thr Ala Trp Arg Gly Met Arg Pro Glu Val 
1               5                   10                  15      


Thr Leu Ala Cys Leu Leu Leu Ala Thr Ala Gly Cys Phe Ala Asp Leu 
            20                  25                  30          


Asn Glu Val Pro Gln Val Thr Val Gln Pro Ala Ser Thr Val Gln Lys 
        35                  40                  45              


Pro Gly Gly Thr Val Ile Leu Gly Cys Val Val Glu Pro Pro Arg Met 
    50                  55                  60                  


Asn Val Thr Trp Arg Leu Asn Gly Lys Glu Leu Asn Gly Ser Asp Asp 
65                  70                  75                  80  


Ala Leu Gly Val Leu Ile Thr His Gly Thr Leu Val Ile Thr Ala Leu 
                85                  90                  95      


Asn Asn His Thr Val Gly Arg Tyr Gln Cys Val Ala Arg Met Pro Ala 
            100                 105                 110         


Gly Ala Val Ala Ser Val Pro Ala Thr Val Thr Leu Ala Asn Leu Gln 
        115                 120                 125             


Asp Phe Lys Leu Asp Val Gln His Val Ile Glu Val Asp Glu Gly Asn 
    130                 135                 140                 


Thr Ala Val Ile Ala Cys His Leu Pro Glu Ser His Pro Lys Ala Gln 
145                 150                 155                 160 


Val Arg Tyr Ser Val Lys Gln Glu Trp Leu Glu Ala Ser Arg Gly Asn 
                165                 170                 175     


Tyr Leu Ile Met Pro Ser Gly Asn Leu Gln Ile Val Asn Ala Ser Gln 
            180                 185                 190         


Glu Asp Glu Gly Met Tyr Lys Cys Ala Ala Tyr Asn Pro Val Thr Gln 
        195                 200                 205             


Glu Val Lys Thr Ser Gly Ser Ser Asp Arg Leu Arg Val Arg Arg Ser 
    210                 215                 220                 


Thr Ala Glu Ala Ala Arg Ile Ile Tyr Pro Pro Glu Ala Gln Thr Ile 
225                 230                 235                 240 


Ile Val Thr Lys Gly Gln Ser Leu Ile Leu Glu Cys Val Ala Ser Gly 
                245                 250                 255     


Ile Pro Pro Pro Arg Val Thr Trp Ala Lys Asp Gly Ser Ser Val Thr 
            260                 265                 270         


Gly Tyr Asn Lys Thr Arg Phe Leu Leu Ser Asn Leu Leu Ile Asp Thr 
        275                 280                 285             


Thr Ser Glu Glu Asp Ser Gly Thr Tyr Arg Cys Met Ala Asp Asn Gly 
    290                 295                 300                 


Val Gly Gln Pro Gly Ala Ala Val Ile Leu Tyr Asn Val Gln Val Phe 
305                 310                 315                 320 


Glu Pro Pro Glu Val Thr Met Glu Leu Ser Gln Leu Val Ile Pro Trp 
                325                 330                 335     


Gly Gln Ser Ala Lys Leu Thr Cys Glu Val Arg Gly Asn Pro Pro Pro 
            340                 345                 350         


Ser Val Leu Trp Leu Arg Asn Ala Val Pro Leu Ile Ser Ser Gln Arg 
        355                 360                 365             


Leu Arg Leu Ser Arg Arg Ala Leu Arg Val Leu Ser Met Gly Pro Glu 
    370                 375                 380                 


Asp Glu Gly Val Tyr Gln Cys Met Ala Glu Asn Glu Val Gly Ser Ala 
385                 390                 395                 400 


His Ala Val Val Gln Leu Arg Thr Ser Arg Pro Ser Ile Thr Pro Arg 
                405                 410                 415     


Leu Trp Gln Asp Ala Glu Leu Ala Thr Gly Thr Pro Pro Val Ser Pro 
            420                 425                 430         


Ser Lys Leu Gly Asn Pro Glu Gln Met Leu Arg Gly Gln Pro Ala Leu 
        435                 440                 445             


Pro Arg Pro Pro Thr Ser Val Gly Pro Ala Ser Pro Gln Cys Pro Gly 
    450                 455                 460                 


Glu Lys Gly Gln Gly Ala Pro Ala Glu Ala Pro Ile Ile Leu Ser Ser 
465                 470                 475                 480 


Pro Arg Thr Ser Lys Thr Asp Ser Tyr Glu Leu Val Trp Arg Pro Arg 
                485                 490                 495     


His Glu Gly Ser Gly Arg Ala Pro Ile Leu Tyr Tyr Val Val Lys His 
            500                 505                 510         


Arg Lys Val Thr Asn Ser Ser Asp Asp Trp Thr Ile Ser Gly Ile Pro 
        515                 520                 525             


Ala Asn Gln His Arg Leu Thr Leu Thr Arg Leu Asp Pro Gly Ser Leu 
    530                 535                 540                 


Tyr Glu Val Glu Met Ala Ala Tyr Asn Cys Ala Gly Glu Gly Gln Thr 
545                 550                 555                 560 


Ala Met Val Thr Phe Arg Thr Gly Arg Arg Pro Lys Pro Glu Ile Met 
                565                 570                 575     


Ala Ser Lys Glu Gln Gln Ile Gln Arg Asp Asp Pro Gly Ala Ser Pro 
            580                 585                 590         


Gln Ser Ser Ser Gln Pro Asp His Gly Arg Leu Ser Pro Pro Glu Ala 
        595                 600                 605             


Pro Asp Arg Pro Thr Ile Ser Thr Ala Ser Glu Thr Ser Val Tyr Val 
    610                 615                 620                 


Thr Trp Ile Pro Arg Gly Asn Gly Gly Phe Pro Ile Gln Ser Phe Arg 
625                 630                 635                 640 


Val Glu Tyr Lys Lys Leu Lys Lys Val Gly Asp Trp Ile Leu Ala Thr 
                645                 650                 655     


Ser Ala Ile Pro Pro Ser Arg Leu Ser Val Glu Ile Thr Gly Leu Glu 
            660                 665                 670         


Lys Gly Thr Ser Tyr Lys Phe Arg Val Arg Ala Leu Asn Met Leu Gly 
        675                 680                 685             


Glu Ser Glu Pro Ser Ala Pro Ser Arg Pro Tyr Val Val Ser Gly Tyr 
    690                 695                 700                 


Ser Gly Arg Val Tyr Glu Arg Pro Val Ala Gly Pro Tyr Ile Thr Phe 
705                 710                 715                 720 


Thr Asp Ala Val Asn Glu Thr Thr Ile Met Leu Lys Trp Met Tyr Ile 
                725                 730                 735     


Pro Ala Ser Asn Asn Asn Thr Pro Ile His Gly Phe Tyr Ile Tyr Tyr 
            740                 745                 750         


Arg Pro Thr Asp Ser Asp Asn Asp Ser Asp Tyr Lys Lys Asp Met Val 
        755                 760                 765             


Glu Gly Asp Lys Tyr Trp His Ser Ile Ser His Leu Gln Pro Glu Thr 
    770                 775                 780                 


Ser Tyr Asp Ile Lys Met Gln Cys Phe Asn Glu Gly Gly Glu Ser Glu 
785                 790                 795                 800 


Phe Ser Asn Val Met Ile Cys Glu Thr Lys Ala Arg Lys Ser Ser Gly 
                805                 810                 815     


Gln Pro Gly Arg Leu Pro Pro Pro Thr Leu Ala Pro Pro Gln Pro Pro 
            820                 825                 830         


Leu Pro Glu Thr Ile Glu Arg Pro Val Gly Thr Gly Ala Met Val Ala 
        835                 840                 845             


Arg Ser Ser Asp Leu Pro Tyr Leu Ile Val Gly Val Val Leu Gly Ser 
    850                 855                 860                 


Ile Val Leu Ile Ile Val Thr Phe Ile Pro Phe Cys Leu Trp Arg Ala 
865                 870                 875                 880 


Trp Ser Lys Gln Lys His Thr Thr Asp Leu Gly Phe Pro Arg Ser Ala 
                885                 890                 895     


Leu Pro Pro Ser Cys Pro Tyr Thr Met Val Pro Leu Gly Gly Leu Pro 
            900                 905                 910         


Gly His Gln Ala Ser Gly Gln Pro Tyr Leu Ser Gly Ile Ser Gly Arg 
        915                 920                 925             


Ala Cys Ala Asn Gly Ile His Met Asn Arg Gly Cys Pro Ser Ala Ala 
    930                 935                 940                 


Val Gly Tyr Pro Gly Met Lys Pro Gln Gln His Cys Pro Gly Glu Leu 
945                 950                 955                 960 


Gln Gln Gln Ser Asp Thr Ser Ser Leu Leu Arg Gln Thr His Leu Gly 
                965                 970                 975     


Asn Gly Tyr Asp Pro Gln Ser His Gln Ile Thr Arg Gly Pro Lys Ser 
            980                 985                 990         


Ser Pro Asp Glu Gly Ser Phe Leu  Tyr Thr Leu Pro Asp  Asp Ser Thr 
        995                 1000                 1005             


His Gln  Leu Leu Gln Pro His  His Asp Cys Cys Gln  Arg Gln Glu 
    1010                 1015                 1020             


Gln Pro  Ala Ala Val Gly Gln  Ser Gly Val Arg Arg  Ala Pro Asp 
    1025                 1030                 1035             


Ser Pro  Val Leu Glu Ala Val  Trp Asp Pro Pro Phe  His Ser Gly 
    1040                 1045                 1050             


Pro Pro  Cys Cys Leu Gly Leu  Val Pro Val Glu Glu  Val Asp Ser 
    1055                 1060                 1065             


Pro Asp  Ser Cys Gln Val Ser  Gly Gly Asp Trp Cys  Pro Gln His 
    1070                 1075                 1080             


Pro Val  Gly Ala Tyr Val Gly  Gln Glu Pro Gly Met  Gln Leu Ser 
    1085                 1090                 1095             


Pro Gly  Pro Leu Val Arg Val  Ser Phe Glu Thr Pro  Pro Leu Thr 
    1100                 1105                 1110             


Ile 
    


<210>  1521
<211>  157
<212>  PRT
<213>  Homo Sapiens

<400>  1521

Met Leu Arg Gly Thr Met Thr Ala Trp Arg Gly Met Arg Pro Glu Val 
1               5                   10                  15      


Thr Leu Ala Cys Leu Leu Leu Ala Thr Ala Gly Cys Phe Ala Asp Leu 
            20                  25                  30          


Asn Glu Val Pro Gln Val Thr Val Gln Pro Ala Ser Thr Val Gln Lys 
        35                  40                  45              


Pro Gly Gly Thr Val Ile Leu Gly Cys Val Val Glu Pro Pro Arg Met 
    50                  55                  60                  


Asn Val Thr Trp Arg Leu Asn Gly Lys Glu Leu Asn Gly Ser Asp Asp 
65                  70                  75                  80  


Ala Leu Gly Val Leu Ile Thr His Gly Thr Leu Val Ile Thr Ala Leu 
                85                  90                  95      


Asn Asn His Thr Val Gly Arg Tyr Gln Cys Val Ala Arg Met Pro Ala 
            100                 105                 110         


Gly Ala Val Ala Ser Val Pro Ala Thr Val Thr Leu Ala Ser Glu Ser 
        115                 120                 125             


Ala Pro Leu Pro Pro Cys His Gly Ala Val Pro Pro His Leu Ser His 
    130                 135                 140                 


Pro Glu Ala Pro Thr Ile His Ala Ala Ser Cys Tyr Ser 
145                 150                 155         


<210>  1522
<211>  157
<212>  PRT
<213>  Homo Sapiens

<400>  1522

Met Leu Arg Gly Thr Met Thr Ala Trp Arg Gly Met Arg Pro Glu Val 
1               5                   10                  15      


Thr Leu Ala Cys Leu Leu Leu Ala Thr Ala Gly Cys Phe Ala Asp Leu 
            20                  25                  30          


Asn Glu Val Pro Gln Val Thr Val Gln Pro Ala Ser Thr Val Gln Lys 
        35                  40                  45              


Pro Gly Gly Thr Val Ile Leu Gly Cys Val Val Glu Pro Pro Arg Met 
    50                  55                  60                  


Asn Val Thr Trp Arg Leu Asn Gly Lys Glu Leu Asn Gly Ser Asp Asp 
65                  70                  75                  80  


Ala Leu Gly Val Leu Ile Thr His Gly Thr Leu Val Ile Thr Ala Leu 
                85                  90                  95      


Asn Asn His Thr Val Gly Arg Tyr Gln Cys Val Ala Arg Met Pro Ala 
            100                 105                 110         


Gly Ala Val Ala Ser Val Pro Ala Thr Val Thr Leu Ala Ser Glu Ser 
        115                 120                 125             


Ala Pro Leu Pro Pro Cys His Gly Ala Val Pro Pro His Leu Ser His 
    130                 135                 140                 


Pro Glu Ala Pro Thr Ile His Ala Ala Ser Cys Tyr Ser 
145                 150                 155         


<210>  1523
<211>  65
<212>  PRT
<213>  Homo Sapiens

<400>  1523

Met Thr His Glu Val Leu Ser Thr Phe Ile Pro Ser Glu Gly Ser Ser 
1               5                   10                  15      


Ser Lys Val Glu Glu Val Asp Leu Gln Asp Phe Lys Leu Asp Val Gln 
            20                  25                  30          


His Val Ile Glu Val Asp Glu Gly Asn Thr Ala Val Ile Ala Cys His 
        35                  40                  45              


Leu Pro Glu Ser His Pro Lys Ala Gln Val Arg Tyr Ser Val Lys Gln 
    50                  55                  60                  


Glu 
65  


<210>  1524
<211>  39
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1524

Xaa Gln Gln Gln Ser Asp Thr Ser Ser Leu Leu Arg Gln Thr His Leu 
1               5                   10                  15      


Gly Asn Gly Tyr Asp Pro Gln Ser His Gln Ile Thr Arg Ala Pro Met 
            20                  25                  30          


Leu Leu Gly Pro Cys Ala Ser 
        35                  


<210>  1525
<211>  84
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1525

Xaa Arg Ala Cys Ala Asn Gly Ile His Met Asn Arg Gly Cys Pro Ser 
1               5                   10                  15      


Ala Ala Val Gly Tyr Pro Gly Met Lys Pro Gln Gln His Cys Pro Gly 
            20                  25                  30          


Glu Leu Gln Gln Gln Ser Asp Thr Ser Ser Leu Leu Arg Gln Thr His 
        35                  40                  45              


Leu Gly Asn Gly Tyr Asp Pro Gln Ser His Gln Ile Thr Ser Cys Cys 
    50                  55                  60                  


Ser Pro Ile Thr Thr Ala Ala Asn Ala Arg Ser Ser Leu Leu Leu Trp 
65                  70                  75                  80  


Ala Ser Gln Gly 
                


<210>  1526
<211>  85
<212>  PRT
<213>  Homo Sapiens

<400>  1526

Met Ala Asp Gly Gly Gly Gly Gly Gly Thr Gly Ala Val Gly Gly Gly 
1               5                   10                  15      


Gly Thr Ser Gln Ala Ser Ala Gly Ala Ala Thr Gly Ala Thr Gly Ala 
            20                  25                  30          


Ser Gly Gly Gly Gly Pro Ile Asn Pro Ala Ser Leu Pro Pro Gly Asp 
        35                  40                  45              


Pro Gln Leu Ile Ala Leu Ile Val Glu Gln Leu Lys Ser Arg Gly Leu 
    50                  55                  60                  


Phe Asp Ser Phe Arg Arg Asp Cys Leu Ala Asp Val Asp Thr Lys Asn 
65                  70                  75                  80  


Thr Pro Asp Thr Phe 
                85  


<210>  1527
<211>  129
<212>  PRT
<213>  Homo Sapiens

<400>  1527

Met Ala Asp Gly Gly Gly Gly Gly Gly Thr Gly Ala Val Gly Gly Gly 
1               5                   10                  15      


Gly Thr Ser Gln Ala Ser Ala Gly Ala Ala Thr Gly Ala Thr Gly Ala 
            20                  25                  30          


Ser Gly Gly Gly Gly Pro Ile Asn Pro Ala Ser Leu Pro Pro Gly Asp 
        35                  40                  45              


Pro Gln Leu Ile Ala Leu Ile Val Glu Gln Leu Lys Ser Arg Gly Leu 
    50                  55                  60                  


Phe Asp Ser Phe Arg Arg Asp Cys Leu Ala Asp Val Asp Thr Lys Pro 
65                  70                  75                  80  


Ala Tyr Gln Asn Leu Arg Gln Lys Val Asp Asn Phe Val Ser Thr His 
                85                  90                  95      


Leu Asp Lys Gln Glu Trp Asn Pro Thr Met Asn Lys Asn Gln Leu Arg 
            100                 105                 110         


Asn Gly Leu Arg Gln Ser Val Val Gln Ile Arg Gln Thr Pro Phe Glu 
        115                 120                 125             


Ser 
    


<210>  1528
<211>  185
<212>  PRT
<213>  Homo Sapiens

<400>  1528

Met Ala Asp Gly Gly Gly Gly Gly Gly Thr Gly Ala Val Gly Gly Gly 
1               5                   10                  15      


Gly Thr Ser Gln Ala Ser Ala Gly Ala Ala Thr Gly Ala Thr Gly Ala 
            20                  25                  30          


Ser Gly Gly Gly Gly Pro Ile Asn Pro Ala Ser Leu Pro Pro Gly Asp 
        35                  40                  45              


Pro Gln Leu Ile Ala Leu Ile Val Glu Gln Leu Lys Ser Arg Gly Leu 
    50                  55                  60                  


Phe Asp Ser Phe Arg Arg Asp Cys Leu Ala Asp Val Asp Thr Lys Pro 
65                  70                  75                  80  


Ala Tyr Gln Asn Leu Arg Gln Lys Val Asp Asn Phe Val Ser Thr His 
                85                  90                  95      


Leu Asp Lys Gln Glu Trp Asn Pro Thr Met Asn Lys Asn Gln Leu Arg 
            100                 105                 110         


Asn Gly Leu Arg Gln Ser Val Val Gln Ser Gly Met Leu Glu Ala Gly 
        115                 120                 125             


Val Asp Arg Ile Ile Ser Gln Val Val Asp Pro Lys Leu Asn His Ile 
    130                 135                 140                 


Phe Arg Pro Gln Ile Glu Arg Ala Ile His Glu Phe Leu Ala Ala Gln 
145                 150                 155                 160 


Lys Lys Ala Ala Val Pro Ala Pro Pro Pro Glu Pro Glu Gly Gln Asp 
                165                 170                 175     


Pro Pro Ala Pro Ser Gln Asp Thr Ser 
            180                 185 


<210>  1529
<211>  42
<212>  PRT
<213>  Homo Sapiens

<400>  1529

Met Asn Lys Asn Gln Leu Arg Asn Gly Leu Arg Gln Ser Val Val Gln 
1               5                   10                  15      


Ser Gly Met Leu Glu Ala Gly Val Asp Arg Ile Ile Ser Gln Val Val 
            20                  25                  30          


Asp Pro Lys Leu Asn His Ile Phe Arg Pro 
        35                  40          


<210>  1530
<211>  118
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1530

Xaa Leu Ala Leu Leu Gly Pro Ala Gly Ala Val Ala Pro Ser Thr Arg 
1               5                   10                  15      


Pro Arg Cys Leu Pro Ala Thr Arg Ser Ser Ser Leu Ser Ser Trp Ser 
            20                  25                  30          


Ser Ser Arg Ala Gly Ala Phe Leu Thr Ala Ser Ala Gly Thr Ala Trp 
        35                  40                  45              


Pro Thr Trp Thr Pro Arg Ser Gly Met Leu Glu Ala Gly Val Asp Arg 
    50                  55                  60                  


Ile Ile Ser Gln Val Val Asp Pro Lys Leu Asn His Ile Phe Arg Pro 
65                  70                  75                  80  


Gln Ile Glu Arg Ala Ile His Glu Phe Leu Ala Ala Gln Lys Lys Ala 
                85                  90                  95      


Ala Val Pro Ala Pro Pro Pro Glu Pro Glu Gly Gln Asp Pro Pro Ala 
            100                 105                 110         


Pro Ser Gln Asp Thr Ser 
        115             


<210>  1531
<211>  137
<212>  PRT
<213>  Homo Sapiens

<400>  1531

Met Leu Ser Gly Arg Leu Val Leu Gly Leu Val Ser Met Ala Gly Arg 
1               5                   10                  15      


Val Cys Leu Cys Gln Gly Ser Ala Gly Ser Gly Ala Ile Gly Pro Val 
            20                  25                  30          


Glu Ala Ala Ile Arg Thr Lys Leu Glu Glu Ala Leu Ser Pro Glu Val 
        35                  40                  45              


Leu Glu Leu Arg Asn Glu Ser Gly Gly His Ala Val Pro Pro Gly Ser 
    50                  55                  60                  


Glu Thr His Phe Arg Val Ala Val Val Ser Ser Arg Phe Glu Gly Leu 
65                  70                  75                  80  


Ser Pro Leu Gln Arg His Arg Leu Val His Ala Ala Leu Ala Glu Glu 
                85                  90                  95      


Leu Gly Gly Pro Val His Ala Leu Ala Ile Gln Ala Arg Thr Pro Ala 
            100                 105                 110         


Gln Trp Arg Glu Asn Ser Gln Leu Asp Thr Ser Pro Pro Cys Leu Gly 
        115                 120                 125             


Gly Asn Lys Lys Thr Leu Gly Thr Pro 
    130                 135         


<210>  1532
<211>  137
<212>  PRT
<213>  Homo Sapiens

<400>  1532

Met Leu Ser Gly Arg Leu Val Leu Gly Leu Val Ser Met Ala Gly Arg 
1               5                   10                  15      


Val Cys Leu Cys Gln Gly Ser Ala Gly Ser Gly Ala Ile Gly Pro Val 
            20                  25                  30          


Glu Ala Ala Ile Arg Thr Lys Leu Glu Glu Ala Leu Ser Pro Glu Val 
        35                  40                  45              


Leu Glu Leu Arg Asn Glu Ser Gly Gly His Ala Val Pro Pro Gly Ser 
    50                  55                  60                  


Glu Thr His Phe Arg Val Ala Val Val Ser Ser Arg Phe Glu Gly Leu 
65                  70                  75                  80  


Ser Pro Leu Gln Arg His Arg Leu Val His Ala Ala Leu Ala Glu Glu 
                85                  90                  95      


Leu Gly Gly Pro Val His Ala Leu Ala Ile Gln Ala Arg Thr Pro Ala 
            100                 105                 110         


Gln Trp Arg Glu Asn Ser Gln Leu Asp Thr Ser Pro Pro Cys Leu Gly 
        115                 120                 125             


Gly Asn Lys Lys Thr Leu Gly Thr Pro 
    130                 135         


<210>  1533
<211>  137
<212>  PRT
<213>  Homo Sapiens

<400>  1533

Met Leu Ser Gly Arg Leu Val Leu Gly Leu Val Ser Met Ala Gly Arg 
1               5                   10                  15      


Val Cys Leu Cys Gln Gly Ser Ala Gly Ser Gly Ala Ile Gly Pro Val 
            20                  25                  30          


Glu Ala Ala Ile Arg Thr Lys Leu Glu Glu Ala Leu Ser Pro Glu Val 
        35                  40                  45              


Leu Glu Leu Arg Asn Glu Ser Gly Gly His Ala Val Pro Pro Gly Ser 
    50                  55                  60                  


Glu Thr His Phe Arg Val Ala Val Val Ser Ser Arg Phe Glu Gly Leu 
65                  70                  75                  80  


Ser Pro Leu Gln Arg His Arg Leu Val His Ala Ala Leu Ala Glu Glu 
                85                  90                  95      


Leu Gly Gly Pro Val His Ala Leu Ala Ile Gln Ala Arg Thr Pro Ala 
            100                 105                 110         


Gln Trp Arg Glu Asn Ser Gln Leu Asp Thr Ser Pro Pro Cys Leu Gly 
        115                 120                 125             


Gly Asn Lys Lys Thr Leu Gly Thr Pro 
    130                 135         


<210>  1534
<211>  55
<212>  PRT
<213>  Homo Sapiens

<400>  1534

Met Glu Asn Val Cys Glu Lys Val Thr Asn Ser Val Ser Ser Glu Leu 
1               5                   10                  15      


Gln Pro Tyr Phe Gln Thr Leu Pro Val Met Thr Lys Ile Asp Ser Val 
            20                  25                  30          


Ala Gly Ile Asn Tyr Gly Leu Val Ala Pro Pro Ala Thr Thr Ala Glu 
        35                  40                  45              


Thr Leu Asp Val Gln Met Lys 
    50                  55  


<210>  1535
<211>  286
<212>  PRT
<213>  Homo Sapiens

<400>  1535

Met Glu Asn Val Cys Glu Lys Val Thr Asn Ser Val Ser Ser Glu Leu 
1               5                   10                  15      


Gln Pro Tyr Phe Gln Thr Leu Pro Val Met Thr Lys Ile Asp Ser Val 
            20                  25                  30          


Ala Gly Ile Asn Tyr Gly Leu Val Ala Pro Pro Ala Thr Thr Ala Glu 
        35                  40                  45              


Thr Leu Asp Val Gln Met Lys Gly Glu Phe Tyr Ser Glu Asn His His 
    50                  55                  60                  


Asn Pro Pro Pro Phe Ala Pro Pro Val Met Glu Phe Pro Ala Ala His 
65                  70                  75                  80  


Asp Arg Met Val Tyr Leu Gly Leu Ser Asp Tyr Phe Phe Asn Thr Ala 
                85                  90                  95      


Gly Leu Val Tyr Gln Glu Ala Gly Val Leu Lys Met Thr Leu Arg Asp 
            100                 105                 110         


Asp Met Ile Pro Lys Glu Ser Lys Phe Arg Leu Thr Thr Lys Phe Phe 
        115                 120                 125             


Gly Thr Phe Leu Pro Glu Val Ala Lys Lys Phe Pro Asn Met Lys Ile 
    130                 135                 140                 


Gln Ile His Val Ser Ala Ser Thr Pro Pro His Leu Ser Val Gln Pro 
145                 150                 155                 160 


Thr Gly Leu Thr Phe Tyr Pro Ala Val Asp Val Gln Ala Phe Ala Val 
                165                 170                 175     


Leu Pro Asn Ser Ser Leu Ala Ser Leu Phe Leu Ile Gly Met His Thr 
            180                 185                 190         


Thr Gly Ser Met Glu Val Ser Ala Glu Ser Asn Arg Leu Val Gly Glu 
        195                 200                 205             


Leu Lys Leu Asp Arg Leu Leu Leu Glu Leu Lys His Ser Asn Ile Gly 
    210                 215                 220                 


Pro Phe Pro Val Glu Leu Leu Gln Asp Ile Met Asn Tyr Ile Val Pro 
225                 230                 235                 240 


Ile Leu Val Leu Pro Arg Val Asn Glu Lys Leu Gln Lys Gly Phe Pro 
                245                 250                 255     


Leu Pro Thr Pro Ala Arg Val Gln Leu Tyr Asn Val Val Leu Gln Pro 
            260                 265                 270         


His Gln Asn Phe Leu Leu Phe Gly Ala Asp Val Val Tyr Lys 
        275                 280                 285     


<210>  1536
<211>  487
<212>  PRT
<213>  Homo Sapiens

<400>  1536

Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Ala 
1               5                   10                  15      


Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val 
            20                  25                  30          


Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala 
        35                  40                  45              


Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys 
    50                  55                  60                  


Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly 
65                  70                  75                  80  


His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser 
                85                  90                  95      


Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser 
            100                 105                 110         


Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe 
        115                 120                 125             


Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile 
    130                 135                 140                 


Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr 
145                 150                 155                 160 


Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His 
                165                 170                 175     


Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys 
            180                 185                 190         


Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys 
        195                 200                 205             


Val Thr Asn Ser Val Ser Ser Glu Leu Gln Pro Tyr Phe Gln Thr Leu 
    210                 215                 220                 


Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu 
225                 230                 235                 240 


Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys 
                245                 250                 255     


Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro 
            260                 265                 270         


Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly 
        275                 280                 285             


Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala 
    290                 295                 300                 


Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser 
305                 310                 315                 320 


Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val 
                325                 330                 335     


Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser 
            340                 345                 350         


Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro 
        355                 360                 365             


Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala 
    370                 375                 380                 


Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser 
385                 390                 395                 400 


Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu 
                405                 410                 415     


Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu 
            420                 425                 430         


Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val 
        435                 440                 445             


Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val 
    450                 455                 460                 


Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe 
465                 470                 475                 480 


Gly Ala Asp Val Val Tyr Lys 
                485         


<210>  1537
<211>  261
<212>  PRT
<213>  Homo Sapiens

<400>  1537

Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu Val Ala 
1               5                   10                  15      


Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys Gly Glu 
            20                  25                  30          


Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro Pro Val 
        35                  40                  45              


Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly Leu Ser 
    50                  55                  60                  


Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala Gly Val 
65                  70                  75                  80  


Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser Lys Phe 
                85                  90                  95      


Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val Ala Lys 
            100                 105                 110         


Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser Thr Pro 
        115                 120                 125             


Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro Ala Val 
    130                 135                 140                 


Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala Ser Leu 
145                 150                 155                 160 


Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser Ala Glu 
                165                 170                 175     


Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu Leu Glu 
            180                 185                 190         


Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu Gln Asp 
        195                 200                 205             


Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val Asn Glu 
    210                 215                 220                 


Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val Gln Leu 
225                 230                 235                 240 


Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe Gly Ala 
                245                 250                 255     


Asp Val Val Tyr Lys 
            260     


<210>  1538
<211>  242
<212>  PRT
<213>  Homo Sapiens

<400>  1538

Met Phe Gln Thr Gly Gly Leu Ile Val Phe Tyr Gly Leu Leu Ala Gln 
1               5                   10                  15      


Thr Leu Pro Leu Asn Val Asn Pro Ala Leu Pro Leu Ser Pro Thr Gly 
            20                  25                  30          


Leu Ala Gly Ser Leu Thr Asn Ala Leu Ser Asn Gly Leu Leu Ser Gly 
        35                  40                  45              


Gly Leu Leu Gly Ile Leu Glu Asn Leu Pro Leu Leu Asp Ile Leu Lys 
    50                  55                  60                  


Pro Gly Gly Gly Thr Ser Gly Gly Leu Leu Gly Gly Leu Leu Gly Lys 
65                  70                  75                  80  


Val Thr Ser Val Ile Pro Gly Leu Asn Asn Ile Ile Asp Ile Lys Val 
                85                  90                  95      


Thr Asp Pro Gln Leu Leu Glu Leu Gly Leu Val Gln Ser Pro Asp Gly 
            100                 105                 110         


His Arg Leu Tyr Val Thr Ile Pro Leu Gly Ile Lys Leu Gln Val Asn 
        115                 120                 125             


Thr Pro Leu Val Gly Ala Ser Leu Leu Arg Leu Ala Val Lys Leu Asp 
    130                 135                 140                 


Ile Thr Ala Glu Ile Leu Ala Val Arg Asp Lys Gln Glu Arg Ile His 
145                 150                 155                 160 


Leu Val Leu Gly Asp Cys Thr His Ser Pro Gly Ser Leu Gln Ile Ser 
                165                 170                 175     


Leu Leu Asp Gly Leu Gly Pro Leu Pro Ile Gln Gly Leu Leu Asp Ser 
            180                 185                 190         


Leu Thr Gly Ile Leu Asn Lys Val Leu Pro Glu Leu Val Gln Gly Asn 
        195                 200                 205             


Val Cys Pro Leu Val Asn Glu Val Leu Arg Gly Leu Asp Ile Thr Leu 
    210                 215                 220                 


Val His Asp Ile Val Asn Met Leu Ile His Gly Leu Gln Phe Val Ile 
225                 230                 235                 240 


Lys Val 
        


<210>  1539
<211>  256
<212>  PRT
<213>  Homo Sapiens

<400>  1539

Met Phe Gln Thr Gly Gly Leu Ile Val Phe Tyr Gly Leu Leu Ala Gln 
1               5                   10                  15      


Thr Met Ala Gln Phe Gly Gly Leu Pro Val Pro Leu Asp Gln Thr Leu 
            20                  25                  30          


Pro Leu Asn Val Asn Pro Ala Leu Pro Leu Ser Pro Thr Gly Leu Ala 
        35                  40                  45              


Gly Ser Leu Thr Asn Ala Leu Ser Asn Gly Leu Leu Ser Gly Gly Leu 
    50                  55                  60                  


Leu Gly Ile Leu Glu Asn Leu Pro Leu Leu Asp Ile Leu Lys Pro Gly 
65                  70                  75                  80  


Gly Gly Thr Ser Gly Gly Leu Leu Gly Gly Leu Leu Gly Lys Val Thr 
                85                  90                  95      


Ser Val Ile Pro Gly Leu Asn Asn Ile Ile Asp Ile Lys Val Thr Asp 
            100                 105                 110         


Pro Gln Leu Leu Glu Leu Gly Leu Val Gln Ser Pro Asp Gly His Arg 
        115                 120                 125             


Leu Tyr Val Thr Ile Pro Leu Gly Ile Lys Leu Gln Val Asn Thr Pro 
    130                 135                 140                 


Leu Val Gly Ala Ser Leu Leu Arg Leu Ala Val Lys Leu Asp Ile Thr 
145                 150                 155                 160 


Ala Glu Ile Leu Ala Val Arg Asp Lys Gln Glu Arg Ile His Leu Val 
                165                 170                 175     


Leu Gly Asp Cys Thr His Ser Pro Gly Ser Leu Gln Ile Ser Leu Leu 
            180                 185                 190         


Asp Gly Leu Gly Pro Leu Pro Ile Gln Gly Leu Leu Asp Ser Leu Thr 
        195                 200                 205             


Gly Ile Leu Asn Lys Val Leu Pro Glu Leu Val Gln Gly Asn Val Cys 
    210                 215                 220                 


Pro Leu Val Asn Glu Val Leu Arg Gly Leu Asp Ile Thr Leu Val His 
225                 230                 235                 240 


Asp Ile Val Asn Met Leu Ile His Gly Leu Gln Phe Val Ile Lys Val 
                245                 250                 255     


<210>  1540
<211>  256
<212>  PRT
<213>  Homo Sapiens

<400>  1540

Met Phe Gln Thr Gly Gly Leu Ile Val Phe Tyr Gly Leu Leu Ala Gln 
1               5                   10                  15      


Thr Met Ala Gln Phe Gly Gly Leu Pro Val Pro Leu Asp Gln Thr Leu 
            20                  25                  30          


Pro Leu Asn Val Asn Pro Ala Leu Pro Leu Ser Pro Thr Gly Leu Ala 
        35                  40                  45              


Gly Ser Leu Thr Asn Ala Leu Ser Asn Gly Leu Leu Ser Gly Gly Leu 
    50                  55                  60                  


Leu Gly Ile Leu Glu Asn Leu Pro Leu Leu Asp Ile Leu Lys Pro Gly 
65                  70                  75                  80  


Gly Gly Thr Ser Gly Gly Leu Leu Gly Gly Leu Leu Gly Lys Val Thr 
                85                  90                  95      


Ser Val Ile Pro Gly Leu Asn Asn Ile Ile Asp Ile Lys Val Thr Asp 
            100                 105                 110         


Pro Gln Leu Leu Glu Leu Gly Leu Val Gln Ser Pro Asp Gly His Arg 
        115                 120                 125             


Leu Tyr Val Thr Ile Pro Leu Gly Ile Lys Leu Gln Val Asn Thr Pro 
    130                 135                 140                 


Leu Val Gly Ala Ser Leu Leu Arg Leu Ala Val Lys Leu Asp Ile Thr 
145                 150                 155                 160 


Ala Glu Ile Leu Ala Val Arg Asp Lys Gln Glu Arg Ile His Leu Val 
                165                 170                 175     


Leu Gly Asp Cys Thr His Ser Pro Gly Ser Leu Gln Ile Ser Leu Leu 
            180                 185                 190         


Asp Gly Leu Gly Pro Leu Pro Ile Gln Gly Leu Leu Asp Ser Leu Thr 
        195                 200                 205             


Gly Ile Leu Asn Lys Val Leu Pro Glu Leu Val Gln Gly Asn Val Cys 
    210                 215                 220                 


Pro Leu Val Asn Glu Val Leu Arg Gly Leu Asp Ile Thr Leu Val His 
225                 230                 235                 240 


Asp Ile Val Asn Met Leu Ile His Gly Leu Gln Phe Val Ile Lys Val 
                245                 250                 255     


<210>  1541
<211>  256
<212>  PRT
<213>  Homo Sapiens

<400>  1541

Met Phe Gln Thr Gly Gly Leu Ile Val Phe Tyr Gly Leu Leu Ala Gln 
1               5                   10                  15      


Thr Met Ala Gln Phe Gly Gly Leu Pro Val Pro Leu Asp Gln Thr Leu 
            20                  25                  30          


Pro Leu Asn Val Asn Pro Ala Leu Pro Leu Ser Pro Thr Gly Leu Ala 
        35                  40                  45              


Gly Ser Leu Thr Asn Ala Leu Ser Asn Gly Leu Leu Ser Gly Gly Leu 
    50                  55                  60                  


Leu Gly Ile Leu Glu Asn Leu Pro Leu Leu Asp Ile Leu Lys Pro Gly 
65                  70                  75                  80  


Gly Gly Thr Ser Gly Gly Leu Leu Gly Gly Leu Leu Gly Lys Val Thr 
                85                  90                  95      


Ser Val Ile Pro Gly Leu Asn Asn Ile Ile Asp Ile Lys Val Thr Asp 
            100                 105                 110         


Pro Gln Leu Leu Glu Leu Gly Leu Val Gln Ser Pro Asp Gly His Arg 
        115                 120                 125             


Leu Tyr Val Thr Ile Pro Leu Gly Ile Lys Leu Gln Val Asn Thr Pro 
    130                 135                 140                 


Leu Val Gly Ala Ser Leu Leu Arg Leu Ala Val Lys Leu Asp Ile Thr 
145                 150                 155                 160 


Ala Glu Ile Leu Ala Val Arg Asp Lys Gln Glu Arg Ile His Leu Val 
                165                 170                 175     


Leu Gly Asp Cys Thr His Ser Pro Gly Ser Leu Gln Ile Ser Leu Leu 
            180                 185                 190         


Asp Gly Leu Gly Pro Leu Pro Ile Gln Gly Leu Leu Asp Ser Leu Thr 
        195                 200                 205             


Gly Ile Leu Asn Lys Val Leu Pro Glu Leu Val Gln Gly Asn Val Cys 
    210                 215                 220                 


Pro Leu Val Asn Glu Val Leu Arg Gly Leu Asp Ile Thr Leu Val His 
225                 230                 235                 240 


Asp Ile Val Asn Met Leu Ile His Gly Leu Gln Phe Val Ile Lys Val 
                245                 250                 255     


<210>  1542
<211>  249
<212>  PRT
<213>  Homo Sapiens

<400>  1542

Met Leu Gln Leu Trp Lys Leu Val Leu Leu Cys Gly Val Leu Thr Gly 
1               5                   10                  15      


Thr Ser Glu Ser Leu Leu Asp Asn Leu Gly Asn Asp Leu Ser Asn Val 
            20                  25                  30          


Val Asp Lys Leu Glu Pro Val Leu His Glu Gly Leu Glu Thr Val Asp 
        35                  40                  45              


Asn Thr Leu Lys Gly Ile Leu Glu Lys Leu Lys Val Asp Leu Gly Val 
    50                  55                  60                  


Leu Gln Lys Ser Ser Ala Trp Gln Leu Ala Lys Gln Lys Ala Gln Glu 
65                  70                  75                  80  


Ala Glu Lys Leu Leu Asn Asn Val Ile Ser Lys Leu Leu Pro Thr Asn 
                85                  90                  95      


Thr Asp Ile Phe Gly Leu Lys Ile Ser Asn Ser Leu Ile Leu Asp Val 
            100                 105                 110         


Lys Ala Glu Pro Ile Asp Asp Gly Lys Gly Leu Asn Leu Ser Phe Pro 
        115                 120                 125             


Val Thr Ala Asn Val Thr Val Ala Gly Pro Ile Ile Gly Gln Ile Ile 
    130                 135                 140                 


Asn Leu Lys Ala Ser Leu Asp Leu Leu Thr Ala Val Thr Ile Glu Thr 
145                 150                 155                 160 


Asp Pro Gln Thr His Gln Pro Val Ala Val Leu Gly Glu Cys Ala Ser 
                165                 170                 175     


Asp Pro Thr Ser Ile Ser Leu Ser Leu Leu Asp Lys His Ser Gln Ile 
            180                 185                 190         


Ile Asn Lys Phe Val Asn Ser Val Ile Asn Thr Leu Lys Ser Thr Val 
        195                 200                 205             


Ser Ser Leu Leu Gln Lys Glu Ile Cys Pro Leu Ile Arg Ile Phe Ile 
    210                 215                 220                 


His Ser Leu Asp Val Asn Val Ile Gln Gln Val Val Asp Asn Pro Gln 
225                 230                 235                 240 


His Lys Thr Gln Leu Gln Thr Leu Ile 
                245                 


<210>  1543
<211>  249
<212>  PRT
<213>  Homo Sapiens

<400>  1543

Met Leu Gln Leu Trp Lys Leu Val Leu Leu Cys Gly Val Leu Thr Gly 
1               5                   10                  15      


Thr Ser Glu Ser Leu Leu Asp Asn Leu Gly Asn Asp Leu Ser Asn Val 
            20                  25                  30          


Val Asp Lys Leu Glu Pro Val Leu His Glu Gly Leu Glu Thr Val Asp 
        35                  40                  45              


Asn Thr Leu Lys Gly Ile Leu Glu Lys Leu Lys Val Asp Leu Gly Val 
    50                  55                  60                  


Leu Gln Lys Ser Ser Ala Trp Gln Leu Ala Lys Gln Lys Ala Gln Glu 
65                  70                  75                  80  


Ala Glu Lys Leu Leu Asn Asn Val Ile Ser Lys Leu Leu Pro Thr Asn 
                85                  90                  95      


Thr Asp Ile Phe Gly Leu Lys Ile Ser Asn Ser Leu Ile Leu Asp Val 
            100                 105                 110         


Lys Ala Glu Pro Ile Asp Asp Gly Lys Gly Leu Asn Leu Ser Phe Pro 
        115                 120                 125             


Val Thr Ala Asn Val Thr Val Ala Gly Pro Ile Ile Gly Gln Ile Ile 
    130                 135                 140                 


Asn Leu Lys Ala Ser Leu Asp Leu Leu Thr Ala Val Thr Ile Glu Thr 
145                 150                 155                 160 


Asp Pro Gln Thr His Gln Pro Val Ala Val Leu Gly Glu Cys Ala Ser 
                165                 170                 175     


Asp Pro Thr Ser Ile Ser Leu Ser Leu Leu Asp Lys His Ser Gln Ile 
            180                 185                 190         


Ile Asn Lys Phe Val Asn Ser Val Ile Asn Thr Leu Lys Ser Thr Val 
        195                 200                 205             


Ser Ser Leu Leu Gln Lys Glu Ile Cys Pro Leu Ile Arg Ile Phe Ile 
    210                 215                 220                 


His Ser Leu Asp Val Asn Val Ile Gln Gln Val Val Asp Asn Pro Gln 
225                 230                 235                 240 


His Lys Thr Gln Leu Gln Thr Leu Ile 
                245                 


<210>  1544
<211>  218
<212>  PRT
<213>  Homo Sapiens

<400>  1544

Met Met Cys Pro Leu Trp Arg Leu Leu Ile Phe Leu Gly Leu Leu Ala 
1               5                   10                  15      


Leu Pro Leu Ala Pro His Lys Gln Pro Trp Pro Gly Leu Ala Gln Ala 
            20                  25                  30          


His Arg Asp Asn Lys Ser Thr Leu Ala Arg Ile Ile Ala Gln Gly Leu 
        35                  40                  45              


Ile Lys His Asn Ala Glu Ser Arg Ile Gln Asn Ile His Phe Gly Asp 
    50                  55                  60                  


Arg Leu Asn Ala Ser Ala Gln Val Ala Pro Gly Leu Val Gly Trp Leu 
65                  70                  75                  80  


Ile Ser Gly Arg Lys His Gln Gln Gln Gln Glu Ser Arg Ser Phe Asp 
                85                  90                  95      


Asn Asn Ile Val Lys Met Cys Ala His Met Ser Ile Val Val Glu Phe 
            100                 105                 110         


Trp Leu Glu Lys Asp Glu Phe Gly Arg Arg Asp Leu Val Ile Gly Lys 
        115                 120                 125             


Cys Asp Ala Glu Pro Ser Ser Val His Val Ala Ile Leu Thr Glu Ala 
    130                 135                 140                 


Ile Pro Pro Lys Met Asn Gln Phe Leu Tyr Asn Leu Lys Glu Asn Leu 
145                 150                 155                 160 


Gln Lys Val Leu Pro His Met Val Glu Ser Gln Val Cys Pro Leu Ile 
                165                 170                 175     


Gly Glu Ile Leu Gly Gln Leu Asp Val Lys Leu Leu Lys Ser Leu Ile 
            180                 185                 190         


Glu Gln Glu Ala Ala His Glu Pro Thr His His Glu Thr Ser Gln Pro 
        195                 200                 205             


Ser Ala Cys Gln Ala Gly Glu Ser Pro Ser 
    210                 215             


<210>  1545
<211>  254
<212>  PRT
<213>  Homo Sapiens

<400>  1545

Met Met Cys Pro Leu Trp Arg Leu Leu Ile Phe Leu Gly Leu Leu Ala 
1               5                   10                  15      


Leu Pro Leu Ala Pro His Lys Gln Pro Trp Pro Gly Leu Ala Gln Ala 
            20                  25                  30          


His Arg Asp Asn Lys Ser Thr Leu Ala Arg Ile Ile Ala Gln Gly Leu 
        35                  40                  45              


Ile Lys His Asn Ala Glu Ser Arg Ile Gln Asn Ile His Phe Gly Asp 
    50                  55                  60                  


Arg Leu Asn Ala Ser Ala Gln Val Ala Pro Gly Leu Val Gly Trp Leu 
65                  70                  75                  80  


Ile Ser Gly Arg Lys His Gln Gln Gln Gln Glu Ser Ser Ile Asn Ile 
                85                  90                  95      


Thr Asn Ile Gln Leu Asp Cys Gly Gly Ile Gln Ile Ser Phe His Lys 
            100                 105                 110         


Glu Trp Phe Ser Ala Asn Ile Ser Leu Glu Phe Asp Leu Glu Leu Arg 
        115                 120                 125             


Pro Ser Phe Asp Asn Asn Ile Val Lys Met Cys Ala His Met Ser Ile 
    130                 135                 140                 


Val Val Glu Phe Trp Leu Glu Lys Asp Glu Phe Gly Arg Arg Asp Leu 
145                 150                 155                 160 


Val Ile Gly Lys Cys Asp Ala Glu Pro Ser Ser Val His Val Ala Ile 
                165                 170                 175     


Leu Thr Glu Ala Ile Pro Pro Lys Met Asn Gln Phe Leu Tyr Asn Leu 
            180                 185                 190         


Lys Glu Asn Leu Gln Lys Val Leu Pro His Met Val Glu Ser Gln Val 
        195                 200                 205             


Cys Pro Leu Ile Gly Glu Ile Leu Gly Gln Leu Asp Val Lys Leu Leu 
    210                 215                 220                 


Lys Ser Leu Ile Glu Gln Glu Ala Ala His Glu Pro Thr His His Glu 
225                 230                 235                 240 


Thr Ser Gln Pro Ser Ala Cys Gln Ala Gly Glu Ser Pro Ser 
                245                 250                 


<210>  1546
<211>  147
<212>  PRT
<213>  Homo Sapiens

<400>  1546

Met Ala Gly Pro Trp Thr Phe Thr Leu Leu Cys Gly Leu Leu Ala Ala 
1               5                   10                  15      


Thr Leu Ile Gln Ala Thr Leu Ser Pro Thr Ala Val Leu Ile Leu Gly 
            20                  25                  30          


Pro Lys Val Ile Lys Glu Lys Leu Thr Gln Glu Leu Lys Asp His Asn 
        35                  40                  45              


Ala Thr Ser Ile Leu Gln Gln Leu Pro Leu Leu Ser Ala Met Arg Glu 
    50                  55                  60                  


Lys Pro Ala Gly Gly Ile Pro Val Leu Gly Ser Leu Val Asn Thr Val 
65                  70                  75                  80  


Leu Lys His Ile Ile Trp Leu Lys Val Ile Thr Ala Asn Ile Leu Gln 
                85                  90                  95      


Leu Gln Val Lys Pro Ser Ala Asn Asp Gln Glu Leu Leu Val Lys Ile 
            100                 105                 110         


Pro Leu Asp Met Val Ala Gly Phe Asn Thr Pro Leu Val Lys Thr Ile 
        115                 120                 125             


Val Glu Phe His Met Thr Thr Glu Ala Gln Ala Thr Ile Arg Met Asp 
    130                 135                 140                 


Thr Ser Ala 
145         


<210>  1547
<211>  484
<212>  PRT
<213>  Homo Sapiens

<400>  1547

Met Ala Gly Pro Trp Thr Phe Thr Leu Leu Cys Gly Leu Leu Ala Ala 
1               5                   10                  15      


Thr Leu Ile Gln Ala Thr Leu Ser Pro Thr Ala Val Leu Ile Leu Gly 
            20                  25                  30          


Pro Lys Val Ile Lys Glu Lys Leu Thr Gln Glu Leu Lys Asp His Asn 
        35                  40                  45              


Ala Thr Ser Ile Leu Gln Gln Leu Pro Leu Leu Ser Ala Met Arg Glu 
    50                  55                  60                  


Lys Pro Ala Gly Gly Ile Pro Val Leu Gly Ser Leu Val Asn Thr Val 
65                  70                  75                  80  


Leu Lys His Ile Ile Trp Leu Lys Val Ile Thr Ala Asn Ile Leu Gln 
                85                  90                  95      


Leu Gln Val Lys Pro Ser Ala Asn Asp Gln Glu Leu Leu Val Lys Ile 
            100                 105                 110         


Pro Leu Asp Met Val Ala Gly Phe Asn Thr Pro Leu Val Lys Thr Ile 
        115                 120                 125             


Val Glu Phe His Met Thr Thr Glu Ala Gln Ala Thr Ile Arg Met Asp 
    130                 135                 140                 


Thr Ser Ala Ser Gly Pro Thr Arg Leu Val Leu Ser Asp Cys Ala Thr 
145                 150                 155                 160 


Ser His Gly Ser Leu Arg Ile Gln Leu Leu His Lys Leu Ser Phe Leu 
                165                 170                 175     


Val Asn Ala Leu Ala Lys Gln Val Met Asn Leu Leu Val Pro Ser Leu 
            180                 185                 190         


Pro Asn Leu Val Lys Asn Gln Leu Cys Pro Val Ile Glu Ala Ser Phe 
        195                 200                 205             


Asn Gly Met Tyr Ala Asp Leu Leu Gln Leu Val Lys Val Pro Ile Ser 
    210                 215                 220                 


Leu Ser Ile Asp Arg Leu Glu Phe Asp Leu Leu Tyr Pro Ala Ile Lys 
225                 230                 235                 240 


Gly Asp Thr Ile Gln Leu Tyr Leu Gly Ala Lys Leu Leu Asp Ser Gln 
                245                 250                 255     


Gly Lys Val Thr Lys Trp Phe Asn Asn Ser Ala Ala Ser Leu Thr Met 
            260                 265                 270         


Pro Thr Leu Asp Asn Ile Pro Phe Ser Leu Ile Val Ser Gln Asp Val 
        275                 280                 285             


Val Lys Ala Ala Val Ala Ala Val Leu Ser Pro Glu Glu Phe Met Val 
    290                 295                 300                 


Leu Leu Asp Ser Val Leu Pro Glu Ser Ala His Arg Leu Lys Ser Ser 
305                 310                 315                 320 


Ile Gly Leu Ile Asn Glu Lys Ala Ala Asp Lys Leu Gly Ser Thr Gln 
                325                 330                 335     


Ile Val Lys Ile Leu Thr Gln Asp Thr Pro Glu Phe Phe Ile Asp Gln 
            340                 345                 350         


Gly His Ala Lys Val Ala Gln Leu Ile Val Leu Glu Val Phe Pro Ser 
        355                 360                 365             


Ser Glu Ala Leu Arg Pro Leu Phe Thr Leu Gly Ile Glu Ala Ser Ser 
    370                 375                 380                 


Glu Ala Gln Phe Tyr Thr Lys Gly Asp Gln Leu Ile Leu Asn Leu Asn 
385                 390                 395                 400 


Asn Ile Ser Ser Asp Arg Ile Gln Leu Met Asn Ser Gly Ile Gly Trp 
                405                 410                 415     


Phe Gln Pro Asp Val Leu Lys Asn Ile Ile Thr Glu Ile Ile His Ser 
            420                 425                 430         


Ile Leu Leu Pro Asn Gln Asn Gly Lys Leu Arg Ser Gly Val Pro Val 
        435                 440                 445             


Ser Leu Val Lys Ala Leu Gly Phe Glu Ala Ala Glu Ser Ser Leu Thr 
    450                 455                 460                 


Lys Asp Ala Leu Val Leu Thr Pro Ala Ser Leu Trp Lys Pro Ser Ser 
465                 470                 475                 480 


Pro Val Ser Gln 
                


<210>  1548
<211>  458
<212>  PRT
<213>  Homo Sapiens

<400>  1548

Met Ala Trp Ala Ser Arg Leu Gly Leu Leu Leu Ala Leu Leu Leu Pro 
1               5                   10                  15      


Val Val Gly Ala Ser Thr Pro Gly Thr Val Val Arg Leu Asn Lys Ala 
            20                  25                  30          


Ala Leu Ser Tyr Val Ser Glu Ile Gly Lys Ala Pro Leu Gln Arg Ala 
        35                  40                  45              


Leu Gln Val Thr Val Pro His Phe Leu Asp Trp Ser Gly Glu Ala Leu 
    50                  55                  60                  


Gln Pro Thr Arg Ile Arg Ile Leu Asn Val His Val Pro Arg Leu His 
65                  70                  75                  80  


Leu Lys Phe Ile Ala Gly Phe Gly Val Arg Leu Leu Ala Ala Ala Asn 
                85                  90                  95      


Phe Thr Phe Lys Val Phe Arg Ala Pro Glu Pro Leu Glu Leu Thr Leu 
            100                 105                 110         


Pro Val Glu Leu Leu Ala Asp Thr Arg Val Thr Gln Ser Ser Ile Arg 
        115                 120                 125             


Thr Pro Val Val Ser Ile Ser Ala Cys Ser Leu Phe Ser Gly His Ala 
    130                 135                 140                 


Asn Glu Phe Asp Gly Ser Asn Ser Thr Ser His Ala Leu Leu Val Leu 
145                 150                 155                 160 


Val Gln Lys His Ile Lys Ala Val Leu Ser Asn Lys Leu Cys Leu Ser 
                165                 170                 175     


Ile Ser Asn Leu Val Gln Gly Val Asn Val His Leu Gly Thr Leu Ile 
            180                 185                 190         


Gly Leu Asn Pro Val Gly Pro Glu Ser Gln Ile Arg Tyr Ser Met Val 
        195                 200                 205             


Ser Val Pro Thr Val Thr Ser Asp Tyr Ile Ser Leu Glu Val Asn Ala 
    210                 215                 220                 


Val Leu Phe Leu Leu Gly Lys Pro Ile Ile Leu Pro Thr Asp Ala Thr 
225                 230                 235                 240 


Pro Phe Val Leu Pro Arg His Val Gly Thr Glu Gly Ser Met Ala Thr 
                245                 250                 255     


Val Gly Leu Ser Gln Gln Leu Phe Asp Ser Ala Leu Leu Leu Leu Gln 
            260                 265                 270         


Lys Ala Gly Ala Leu Asn Leu Asp Ile Thr Gly Gln Leu Arg Ser Asp 
        275                 280                 285             


Asp Asn Leu Leu Asn Thr Ser Ala Leu Gly Arg Leu Ile Pro Glu Val 
    290                 295                 300                 


Ala Arg Gln Phe Pro Glu Pro Met Pro Val Val Leu Lys Val Arg Leu 
305                 310                 315                 320 


Gly Ala Thr Pro Val Ala Met Leu His Thr Asn Asn Ala Thr Leu Arg 
                325                 330                 335     


Leu Gln Pro Phe Val Glu Val Leu Ala Thr Ala Ser Asn Ser Ala Phe 
            340                 345                 350         


Gln Ser Leu Phe Ser Leu Asp Val Val Val Asn Leu Arg Leu Gln Leu 
        355                 360                 365             


Ser Val Ser Lys Val Lys Leu Gln Gly Thr Thr Ser Val Leu Gly Asp 
    370                 375                 380                 


Val Gln Leu Thr Val Ala Ser Ser Asn Val Gly Phe Ile Asp Thr Asp 
385                 390                 395                 400 


Gln Val Arg Thr Leu Met Gly Thr Val Phe Glu Lys Pro Leu Leu Asp 
                405                 410                 415     


His Leu Asn Ala Leu Leu Ala Met Gly Ile Ala Leu Pro Gly Val Val 
            420                 425                 430         


Asn Leu His Tyr Val Ala Pro Glu Ile Phe Val Tyr Glu Gly Tyr Val 
        435                 440                 445             


Val Ile Ser Ser Gly Leu Phe Tyr Gln Ser 
    450                 455             


<210>  1549
<211>  476
<212>  PRT
<213>  Homo Sapiens

<400>  1549

Met Gln Pro Val Met Leu Ala Leu Trp Ser Leu Leu Leu Leu Trp Gly 
1               5                   10                  15      


Leu Ala Thr Pro Cys Gln Glu Leu Leu Glu Thr Val Gly Thr Leu Ala 
            20                  25                  30          


Arg Ile Asp Lys Asp Glu Leu Gly Lys Ala Ile Gln Asn Ser Leu Val 
        35                  40                  45              


Gly Glu Pro Ile Leu Gln Asn Val Leu Gly Ser Val Thr Ala Val Asn 
    50                  55                  60                  


Arg Gly Leu Leu Gly Ser Gly Gly Leu Leu Gly Gly Gly Gly Leu Leu 
65                  70                  75                  80  


Gly His Gly Gly Val Phe Gly Val Val Glu Glu Leu Ser Gly Leu Lys 
                85                  90                  95      


Ile Glu Glu Leu Thr Leu Pro Lys Val Leu Leu Lys Leu Leu Pro Gly 
            100                 105                 110         


Phe Gly Val Gln Leu Ser Leu His Thr Lys Val Gly Met His Cys Ser 
        115                 120                 125             


Gly Pro Leu Gly Gly Leu Leu Gln Leu Ala Ala Glu Val Asn Val Thr 
    130                 135                 140                 


Ser Arg Val Ala Leu Ala Val Ser Ser Arg Gly Thr Pro Ile Leu Ile 
145                 150                 155                 160 


Leu Lys Arg Cys Ser Thr Leu Leu Gly His Ile Ser Leu Phe Ser Gly 
                165                 170                 175     


Leu Leu Pro Thr Pro Leu Phe Gly Val Val Glu Gln Met Leu Phe Lys 
            180                 185                 190         


Val Leu Pro Gly Leu Leu Cys Pro Val Val Asp Ser Val Leu Gly Val 
        195                 200                 205             


Val Asn Glu Leu Leu Gly Ala Val Leu Gly Leu Val Ser Leu Gly Ala 
    210                 215                 220                 


Leu Gly Ser Val Glu Phe Ser Leu Ala Thr Leu Pro Leu Ile Ser Asn 
225                 230                 235                 240 


Gln Tyr Ile Glu Leu Asp Ile Asn Pro Ile Val Lys Ser Val Ala Gly 
                245                 250                 255     


Asp Ile Ile Asp Phe Pro Lys Ser Arg Ala Pro Ala Lys Val Pro Pro 
            260                 265                 270         


Lys Lys Asp His Thr Ser Gln Val Met Val Pro Leu Tyr Leu Phe Asn 
        275                 280                 285             


Thr Thr Phe Gly Leu Leu Gln Thr Asn Gly Ala Leu Asp Met Asp Ile 
    290                 295                 300                 


Thr Pro Glu Leu Val Pro Ser Asp Val Pro Leu Thr Thr Thr Asp Leu 
305                 310                 315                 320 


Ala Ala Leu Leu Pro Glu Ala Leu Gly Lys Leu Pro Leu His Gln Gln 
                325                 330                 335     


Leu Leu Leu Phe Leu Arg Val Arg Glu Ala Pro Thr Val Thr Leu His 
            340                 345                 350         


Asn Lys Lys Ala Leu Val Ser Leu Pro Ala Asn Ile His Val Leu Phe 
        355                 360                 365             


Tyr Val Pro Lys Gly Thr Pro Glu Ser Leu Phe Glu Leu Asn Ser Val 
    370                 375                 380                 


Met Thr Val Arg Ala Gln Leu Ala Pro Ser Ala Thr Lys Leu His Ile 
385                 390                 395                 400 


Ser Leu Ser Leu Glu Arg Leu Ser Val Lys Val Ala Ser Ser Phe Thr 
                405                 410                 415     


His Ala Phe Asp Gly Ser Arg Leu Glu Glu Trp Leu Ser His Val Val 
            420                 425                 430         


Gly Ala Val Tyr Ala Pro Lys Leu Asn Val Ala Leu Asp Val Gly Ile 
        435                 440                 445             


Pro Leu Pro Lys Val Leu Asn Ile Asn Phe Ser Asn Ser Val Leu Glu 
    450                 455                 460                 


Ile Val Glu Asn Ala Val Val Leu Thr Val Ala Ser 
465                 470                 475     


<210>  1550
<211>  614
<212>  PRT
<213>  Homo Sapiens

<400>  1550

Met Trp Met Ala Trp Cys Val Ala Ala Leu Ser Val Val Ala Val Cys 
1               5                   10                  15      


Gly Thr Ser His Glu Thr Asn Thr Val Leu Arg Val Thr Lys Asp Val 
            20                  25                  30          


Leu Ser Asn Ala Ile Ser Gly Met Leu Gln Gln Ser Asp Ala Leu His 
        35                  40                  45              


Ser Ala Leu Arg Glu Val Pro Leu Gly Val Gly Asp Ile Pro Tyr Asn 
    50                  55                  60                  


Asp Phe His Val Arg Gly Pro Pro Pro Val Tyr Thr Asn Gly Lys Lys 
65                  70                  75                  80  


Leu Asp Gly Ile Tyr Gln Tyr Gly His Ile Glu Thr Asn Asp Asn Thr 
                85                  90                  95      


Ala Gln Leu Gly Gly Lys Tyr Arg Tyr Gly Glu Ile Leu Glu Ser Glu 
            100                 105                 110         


Gly Ser Ile Arg Asp Leu Arg Asn Ser Gly Tyr Arg Ser Ala Glu Asn 
        115                 120                 125             


Ala Tyr Gly Gly His Arg Gly Leu Gly Arg Tyr Arg Ala Ala Pro Val 
    130                 135                 140                 


Gly Arg Leu His Arg Arg Glu Leu Gln Pro Gly Glu Ile Pro Pro Gly 
145                 150                 155                 160 


Val Ala Thr Gly Ala Val Gly Pro Gly Gly Leu Leu Gly Thr Gly Gly 
                165                 170                 175     


Met Leu Ala Ala Asp Gly Ile Leu Ala Gly Gln Gly Gly Leu Leu Gly 
            180                 185                 190         


Gly Gly Gly Leu Leu Gly Asp Gly Gly Leu Leu Gly Gly Gly Gly Val 
        195                 200                 205             


Leu Gly Val Leu Gly Glu Gly Gly Ile Leu Ser Thr Val Gln Gly Ile 
    210                 215                 220                 


Thr Gly Leu Arg Ile Val Glu Leu Thr Leu Pro Arg Val Ser Val Arg 
225                 230                 235                 240 


Leu Leu Pro Gly Val Gly Val Tyr Leu Ser Leu Tyr Thr Arg Val Ala 
                245                 250                 255     


Ile Asn Gly Lys Ser Leu Ile Gly Phe Leu Asp Ile Ala Val Glu Val 
            260                 265                 270         


Asn Ile Thr Ala Lys Val Arg Leu Thr Met Asp Arg Thr Gly Tyr Pro 
        275                 280                 285             


Arg Leu Val Ile Glu Arg Cys Asp Thr Leu Leu Gly Gly Ile Lys Val 
    290                 295                 300                 


Lys Leu Leu Arg Gly Leu Leu Pro Asn Leu Val Asp Asn Leu Val Asn 
305                 310                 315                 320 


Arg Val Leu Ala Asp Val Leu Pro Asp Leu Leu Cys Pro Ile Val Asp 
                325                 330                 335     


Val Val Leu Gly Leu Val Asn Asp Gln Leu Gly Leu Val Asp Ser Leu 
            340                 345                 350         


Ile Pro Leu Gly Ile Leu Gly Ser Val Gln Tyr Thr Phe Ser Ser Leu 
        355                 360                 365             


Pro Leu Val Thr Gly Glu Phe Leu Glu Leu Asp Leu Asn Thr Leu Val 
    370                 375                 380                 


Gly Glu Ala Gly Gly Gly Leu Ile Asp Tyr Pro Leu Gly Trp Pro Ala 
385                 390                 395                 400 


Val Ser Pro Lys Pro Met Pro Glu Leu Pro Pro Met Gly Asp Asn Thr 
                405                 410                 415     


Lys Ser Gln Leu Ala Met Ser Ala Asn Phe Leu Gly Ser Val Leu Thr 
            420                 425                 430         


Leu Leu Gln Lys Gln His Ala Leu Asp Leu Asp Ile Thr Asn Gly Met 
        435                 440                 445             


Phe Glu Glu Leu Pro Pro Leu Thr Thr Ala Thr Leu Gly Ala Leu Ile 
    450                 455                 460                 


Pro Lys Val Phe Gln Gln Tyr Pro Glu Ser Cys Pro Leu Ile Ile Arg 
465                 470                 475                 480 


Ile Gln Val Leu Asn Pro Pro Ser Val Met Leu Gln Lys Asp Lys Ala 
                485                 490                 495     


Leu Val Lys Val Leu Ala Thr Ala Glu Val Met Val Ser Gln Pro Lys 
            500                 505                 510         


Asp Leu Glu Thr Thr Ile Cys Leu Ile Asp Val Asp Thr Glu Phe Leu 
        515                 520                 525             


Ala Ser Phe Ser Thr Glu Gly Asp Lys Leu Met Ile Asp Ala Lys Leu 
    530                 535                 540                 


Glu Lys Thr Ser Leu Asn Leu Arg Thr Ser Asn Val Gly Asn Phe Asp 
545                 550                 555                 560 


Ile Gly Leu Met Glu Val Leu Val Glu Lys Ile Phe Asp Leu Ala Phe 
                565                 570                 575     


Met Pro Ala Met Asn Ala Val Leu Gly Ser Gly Val Pro Leu Pro Lys 
            580                 585                 590         


Ile Leu Asn Ile Asp Phe Ser Asn Ala Asp Ile Asp Val Leu Glu Asp 
        595                 600                 605             


Leu Leu Val Leu Ser Ala 
    610                 


<210>  1551
<211>  44
<212>  PRT
<213>  Homo Sapiens

<400>  1551

Met Trp Met Ala Trp Cys Val Ala Ala Leu Ser Val Val Ala Val Cys 
1               5                   10                  15      


Gly Thr Ser His Glu Thr Asn Thr Val Leu Arg Val Thr Lys Asp Val 
            20                  25                  30          


Leu Ser Asn Gly Phe Ser Pro Ile Ser Trp Thr Ile 
        35                  40                  


<210>  1552
<211>  453
<212>  PRT
<213>  Homo Sapiens

<400>  1552

Met Leu Arg Ile Leu Cys Leu Ala Leu Cys Ser Leu Leu Thr Gly Thr 
1               5                   10                  15      


Arg Ala Asp Pro Gly Ala Leu Leu Arg Leu Gly Met Asp Ile Met Asn 
            20                  25                  30          


Gln Val Gln Ser Ala Met Asp Glu Ser His Ile Leu Glu Lys Met Ala 
        35                  40                  45              


Ala Glu Ala Gly Lys Lys Gln Pro Gly Met Lys Pro Ile Lys Gly Ile 
    50                  55                  60                  


Thr Asn Leu Lys Val Lys Asp Val Gln Leu Pro Val Ile Thr Leu Asn 
65                  70                  75                  80  


Phe Val Pro Gly Val Gly Ile Phe Gln Cys Val Ser Thr Gly Met Thr 
                85                  90                  95      


Val Thr Gly Lys Ser Phe Met Gly Gly Asn Met Glu Ile Ile Val Ala 
            100                 105                 110         


Leu Asn Ile Thr Ala Thr Asn Arg Leu Leu Arg Asp Glu Glu Thr Gly 
        115                 120                 125             


Leu Pro Val Phe Lys Ser Glu Gly Cys Glu Val Ile Leu Val Asn Val 
    130                 135                 140                 


Lys Thr Asn Leu Pro Ser Asn Met Leu Pro Lys Met Val Asn Lys Phe 
145                 150                 155                 160 


Leu Asp Ser Thr Leu His Lys Val Leu Pro Gly Leu Met Cys Pro Ala 
                165                 170                 175     


Ile Asp Ala Val Leu Val Tyr Val Asn Arg Lys Trp Thr Asn Leu Ser 
            180                 185                 190         


Asp Pro Met Pro Val Gly Gln Met Gly Thr Val Lys Tyr Val Leu Met 
        195                 200                 205             


Ser Ala Pro Ala Thr Thr Ala Ser Tyr Ile Gln Leu Asp Phe Ser Pro 
    210                 215                 220                 


Val Val Gln Gln Gln Lys Gly Lys Thr Ile Lys Leu Ala Asp Ala Gly 
225                 230                 235                 240 


Glu Ala Leu Thr Phe Pro Glu Gly Tyr Ala Lys Gly Ser Ser Gln Leu 
                245                 250                 255     


Leu Leu Pro Ala Thr Phe Leu Ser Ala Glu Leu Ala Leu Leu Gln Lys 
            260                 265                 270         


Ser Phe His Val Asn Ile Gln Asp Thr Met Ile Gly Glu Leu Pro Pro 
        275                 280                 285             


Gln Thr Thr Lys Thr Leu Ala Arg Phe Ile Pro Glu Val Ala Val Ala 
    290                 295                 300                 


Tyr Pro Lys Ser Lys Pro Leu Thr Thr Gln Ile Lys Ile Lys Lys Pro 
305                 310                 315                 320 


Pro Lys Val Thr Met Lys Thr Gly Lys Ser Leu Leu His Leu His Ser 
                325                 330                 335     


Thr Leu Glu Met Phe Ala Ala Arg Trp Arg Ser Lys Ala Pro Met Ser 
            340                 345                 350         


Leu Phe Leu Leu Glu Val His Phe Asn Leu Lys Val Gln Tyr Ser Val 
        355                 360                 365             


His Glu Asn Gln Leu Gln Met Ala Thr Ser Leu Asp Arg Leu Leu Ser 
    370                 375                 380                 


Leu Ser Arg Lys Ser Ser Ser Ile Gly Asn Phe Asn Glu Arg Glu Leu 
385                 390                 395                 400 


Thr Gly Phe Ile Thr Ser Tyr Leu Glu Glu Ala Tyr Ile Pro Val Val 
                405                 410                 415     


Asn Asp Val Leu Gln Val Gly Leu Pro Leu Pro Asp Phe Leu Ala Met 
            420                 425                 430         


Asn Tyr Asn Leu Ala Glu Leu Asp Ile Val Glu Asn Ala Leu Met Leu 
        435                 440                 445             


Asp Leu Lys Leu Gly 
    450             


<210>  1553
<211>  88
<212>  PRT
<213>  Homo Sapiens

<400>  1553

Met Leu Arg Ile Leu Cys Leu Ala Leu Cys Ser Leu Leu Thr Gly Thr 
1               5                   10                  15      


Arg Ala Asp Pro Gly Ala Leu Leu Arg Leu Gly Met Asp Ile Met Asn 
            20                  25                  30          


Arg Glu Val Gln Ser Ala Met Asp Glu Ser His Ile Leu Glu Lys Met 
        35                  40                  45              


Ala Ala Glu Ala Gly Lys Lys Gln Pro Gly Met Lys Pro Ile Lys Gly 
    50                  55                  60                  


Ile Thr Asn Glu Gln Gly His Phe Glu Glu Glu Met Arg Leu Glu Ser 
65                  70                  75                  80  


Gln Ile Ser Thr Leu His Ala Thr 
                85              


<210>  1554
<211>  82
<212>  PRT
<213>  Homo Sapiens

<400>  1554

Met Cys Thr Lys Thr Ile Pro Val Leu Trp Gly Cys Phe Leu Leu Trp 
1               5                   10                  15      


Asn Leu Tyr Val Ser Ser Ser Gln Thr Ile Tyr Pro Gly Ile Lys Ala 
            20                  25                  30          


Arg Ile Thr Gln Arg Ala Leu Asp Tyr Gly Val Gln Ala Gly Met Lys 
        35                  40                  45              


Met Ile Glu Gln Met Leu Lys Glu Lys Lys Leu Pro Asp Leu Ser Gly 
    50                  55                  60                  


Ser Glu Ser Leu Glu Phe Leu Lys Val Asp Tyr Val Asn Tyr Asn Phe 
65                  70                  75                  80  


Ser Lys 
        


<210>  1555
<211>  507
<212>  PRT
<213>  Homo Sapiens

<400>  1555

Met Cys Thr Lys Thr Ile Pro Val Leu Trp Gly Cys Phe Leu Leu Trp 
1               5                   10                  15      


Asn Leu Tyr Val Ser Ser Ser Gln Thr Ile Tyr Pro Gly Ile Lys Ala 
            20                  25                  30          


Arg Ile Thr Gln Arg Ala Leu Asp Tyr Gly Val Gln Ala Gly Met Lys 
        35                  40                  45              


Met Ile Glu Gln Met Leu Lys Glu Lys Lys Leu Pro Asp Leu Ser Gly 
    50                  55                  60                  


Ser Glu Ser Leu Glu Phe Leu Lys Val Asp Tyr Val Asn Tyr Asn Phe 
65                  70                  75                  80  


Ser Asn Ile Lys Ile Ser Ala Phe Ser Phe Pro Asn Thr Ser Leu Ala 
                85                  90                  95      


Phe Val Pro Gly Val Gly Ile Lys Ala Leu Thr Asn His Gly Thr Ala 
            100                 105                 110         


Asn Ile Ser Thr Asp Trp Gly Phe Glu Ser Pro Leu Phe Gln Asp Thr 
        115                 120                 125             


Gly Gly Ala Asp Leu Phe Leu Ser Gly Val Tyr Phe Thr Gly Ile Ile 
    130                 135                 140                 


Ile Leu Thr Arg Asn Asp Phe Gly His Pro Thr Leu Lys Leu Gln Asp 
145                 150                 155                 160 


Cys Tyr Ala Gln Leu Ser His Ala His Val Ser Phe Ser Gly Glu Leu 
                165                 170                 175     


Ser Val Leu Tyr Asn Ser Phe Ala Glu Pro Met Glu Lys Pro Ile Leu 
            180                 185                 190         


Lys Asn Leu Asn Glu Met Leu Cys Pro Ile Ile Ala Ser Glu Val Lys 
        195                 200                 205             


Ala Leu Asn Ala Asn Leu Ser Thr Leu Glu Val Leu Thr Lys Ile Asp 
    210                 215                 220                 


Asn Tyr Thr Leu Leu Asp Tyr Ser Leu Ile Ser Ser Pro Glu Ile Thr 
225                 230                 235                 240 


Glu Asn Tyr Leu Asp Leu Asn Leu Lys Gly Val Phe Tyr Pro Leu Glu 
                245                 250                 255     


Asn Leu Thr Asp Pro Pro Phe Ser Pro Val Pro Phe Val Leu Pro Glu 
            260                 265                 270         


Arg Ser Asn Ser Met Leu Tyr Ile Gly Ile Ala Glu Tyr Phe Phe Lys 
        275                 280                 285             


Ser Ala Ser Phe Ala His Phe Thr Ala Gly Val Phe Asn Val Thr Leu 
    290                 295                 300                 


Ser Thr Glu Glu Ile Ser Asn His Phe Val Gln Asn Ser Gln Gly Leu 
305                 310                 315                 320 


Gly Asn Val Leu Ser Arg Ile Ala Glu Ile Tyr Ile Leu Ser Gln Pro 
                325                 330                 335     


Phe Met Val Arg Ile Met Ala Thr Glu Pro Pro Ile Ile Asn Leu Gln 
            340                 345                 350         


Pro Gly Asn Phe Thr Leu Asp Ile Pro Ala Ser Ile Met Met Leu Thr 
        355                 360                 365             


Gln Pro Lys Asn Ser Thr Val Glu Thr Ile Val Ser Met Asp Phe Val 
    370                 375                 380                 


Ala Ser Thr Ser Val Gly Leu Val Ile Leu Gly Gln Arg Leu Val Cys 
385                 390                 395                 400 


Ser Leu Ser Leu Asn Arg Phe Arg Leu Ala Leu Pro Glu Ser Asn Arg 
                405                 410                 415     


Ser Asn Ile Glu Val Leu Arg Phe Glu Asn Ile Leu Ser Ser Ile Leu 
            420                 425                 430         


His Phe Gly Val Leu Pro Leu Ala Asn Ala Lys Leu Gln Gln Gly Phe 
        435                 440                 445             


Pro Leu Ser Asn Pro His Lys Phe Leu Phe Val Asn Ser Asp Ile Glu 
    450                 455                 460                 


Val Leu Glu Gly Phe Leu Leu Ile Ser Thr Asp Leu Lys Tyr Glu Thr 
465                 470                 475                 480 


Ser Ser Lys Gln Gln Pro Ser Phe His Val Trp Glu Gly Leu Asn Leu 
                485                 490                 495     


Ile Ser Arg Gln Trp Arg Gly Lys Ser Ala Pro 
            500                 505         


<210>  1556
<211>  507
<212>  PRT
<213>  Homo Sapiens

<400>  1556

Met Cys Thr Lys Thr Ile Pro Val Leu Trp Gly Cys Phe Leu Leu Trp 
1               5                   10                  15      


Asn Leu Tyr Val Ser Ser Ser Gln Thr Ile Tyr Pro Gly Ile Lys Ala 
            20                  25                  30          


Arg Ile Thr Gln Arg Ala Leu Asp Tyr Gly Val Gln Ala Gly Met Lys 
        35                  40                  45              


Met Ile Glu Gln Met Leu Lys Glu Lys Lys Leu Pro Asp Leu Ser Gly 
    50                  55                  60                  


Ser Glu Ser Leu Glu Phe Leu Lys Val Asp Tyr Val Asn Tyr Asn Phe 
65                  70                  75                  80  


Ser Asn Ile Lys Ile Ser Ala Phe Ser Phe Pro Asn Thr Ser Leu Ala 
                85                  90                  95      


Phe Val Pro Gly Val Gly Ile Lys Ala Leu Thr Asn His Gly Thr Ala 
            100                 105                 110         


Asn Ile Ser Thr Asp Trp Gly Phe Glu Ser Pro Leu Phe Gln Asp Thr 
        115                 120                 125             


Gly Gly Ala Asp Leu Phe Leu Ser Gly Val Tyr Phe Thr Gly Ile Ile 
    130                 135                 140                 


Ile Leu Thr Arg Asn Asp Phe Gly His Pro Thr Leu Lys Leu Gln Asp 
145                 150                 155                 160 


Cys Tyr Ala Gln Leu Ser His Ala His Val Ser Phe Ser Gly Glu Leu 
                165                 170                 175     


Ser Val Leu Tyr Asn Ser Phe Ala Glu Pro Met Glu Lys Pro Ile Leu 
            180                 185                 190         


Lys Asn Leu Asn Glu Met Leu Cys Pro Ile Ile Ala Ser Glu Val Lys 
        195                 200                 205             


Ala Leu Asn Ala Asn Leu Ser Thr Leu Glu Val Leu Thr Lys Ile Asp 
    210                 215                 220                 


Asn Tyr Thr Leu Leu Asp Tyr Ser Leu Ile Ser Ser Pro Glu Ile Thr 
225                 230                 235                 240 


Glu Asn Tyr Leu Asp Leu Asn Leu Lys Gly Val Phe Tyr Pro Leu Glu 
                245                 250                 255     


Asn Leu Thr Asp Pro Pro Phe Ser Pro Val Pro Phe Val Leu Pro Glu 
            260                 265                 270         


Arg Ser Asn Ser Met Leu Tyr Ile Gly Ile Ala Glu Tyr Phe Phe Lys 
        275                 280                 285             


Ser Ala Ser Phe Ala His Phe Thr Ala Gly Val Phe Asn Val Thr Leu 
    290                 295                 300                 


Ser Thr Glu Glu Ile Ser Asn His Phe Val Gln Asn Ser Gln Gly Leu 
305                 310                 315                 320 


Gly Asn Val Leu Ser Arg Ile Ala Glu Ile Tyr Ile Leu Ser Gln Pro 
                325                 330                 335     


Phe Met Val Arg Ile Met Ala Thr Glu Pro Pro Ile Ile Asn Leu Gln 
            340                 345                 350         


Pro Gly Asn Phe Thr Leu Asp Ile Pro Ala Ser Ile Met Met Leu Thr 
        355                 360                 365             


Gln Pro Lys Asn Ser Thr Val Glu Thr Ile Val Ser Met Asp Phe Val 
    370                 375                 380                 


Ala Ser Thr Ser Val Gly Leu Val Ile Leu Gly Gln Arg Leu Val Cys 
385                 390                 395                 400 


Ser Leu Ser Leu Asn Arg Phe Arg Leu Ala Leu Pro Glu Ser Asn Arg 
                405                 410                 415     


Ser Asn Ile Glu Val Leu Arg Phe Glu Asn Ile Leu Ser Ser Ile Leu 
            420                 425                 430         


His Phe Gly Val Leu Pro Leu Ala Asn Ala Lys Leu Gln Gln Gly Phe 
        435                 440                 445             


Pro Leu Ser Asn Pro His Lys Phe Leu Phe Val Asn Ser Asp Ile Glu 
    450                 455                 460                 


Val Leu Glu Gly Phe Leu Leu Ile Ser Thr Asp Leu Lys Tyr Glu Thr 
465                 470                 475                 480 


Ser Ser Lys Gln Gln Pro Ser Phe His Val Trp Glu Gly Leu Asn Leu 
                485                 490                 495     


Ile Ser Arg Gln Trp Arg Gly Lys Ser Ala Pro 
            500                 505         


<210>  1557
<211>  264
<212>  PRT
<213>  Homo Sapiens

<400>  1557

Met Glu Lys Pro Ile Leu Lys Asn Leu Asn Glu Met Leu Cys Pro Ile 
1               5                   10                  15      


Ile Ala Ser Glu Val Lys Ala Leu Asn Ala Asn Leu Ser Thr Leu Glu 
            20                  25                  30          


Val Leu Thr Lys Ile Asp Asn Tyr Thr Leu Leu Asp Tyr Ser Leu Ile 
        35                  40                  45              


Ser Ser Pro Glu Ile Thr Glu Asn Tyr Leu Asp Leu Asn Leu Lys Gly 
    50                  55                  60                  


Val Phe Tyr Pro Leu Glu Asn Leu Thr Asp Pro Pro Phe Ser Pro Val 
65                  70                  75                  80  


Pro Phe Val Leu Pro Glu Arg Ser Asn Ser Met Leu Tyr Ile Gly Ile 
                85                  90                  95      


Ala Glu Tyr Phe Phe Lys Ser Ala Ser Phe Ala His Phe Thr Ala Gly 
            100                 105                 110         


Val Phe Asn Val Thr Leu Ser Thr Glu Glu Ile Ser Asn His Phe Val 
        115                 120                 125             


Gln Asn Ser Gln Gly Leu Gly Asn Val Leu Ser Arg Val Ala Ser Thr 
    130                 135                 140                 


Ser Val Gly Leu Val Ile Leu Gly Gln Arg Leu Val Cys Ser Leu Ser 
145                 150                 155                 160 


Leu Asn Arg Phe Arg Leu Ala Leu Pro Glu Ser Asn Arg Ser Asn Ile 
                165                 170                 175     


Glu Val Leu Arg Phe Glu Asn Ile Leu Ser Ser Ile Leu His Phe Gly 
            180                 185                 190         


Val Leu Pro Leu Ala Asn Ala Lys Leu Gln Gln Gly Phe Pro Leu Ser 
        195                 200                 205             


Asn Pro His Lys Phe Leu Phe Val Asn Ser Asp Ile Glu Val Leu Glu 
    210                 215                 220                 


Gly Phe Leu Leu Ile Ser Thr Asp Leu Lys Tyr Glu Thr Ser Ser Lys 
225                 230                 235                 240 


Gln Gln Pro Ser Phe His Val Trp Glu Gly Leu Asn Leu Ile Ser Arg 
                245                 250                 255     


Gln Trp Arg Gly Lys Ser Ala Pro 
            260                 


<210>  1558
<211>  64
<212>  PRT
<213>  Homo Sapiens

<400>  1558

Met Ala Val Ser Arg His Leu Thr Arg Gly Arg Lys Met Ala His Val 
1               5                   10                  15      


Ile Ala Ala Cys Leu Tyr Leu Val Cys Arg Thr Glu Gly Thr Pro His 
            20                  25                  30          


Met Leu Leu Asp Leu Ser Asp Leu Leu Gln Val Asn Val Tyr Val Leu 
        35                  40                  45              


Gly Lys Thr Phe Leu Leu Leu Ala Arg Glu Leu Cys Ile Asn Ala Pro 
    50                  55                  60                  


<210>  1559
<211>  562
<212>  PRT
<213>  Homo Sapiens

<400>  1559

Met Ala Val Ser Arg His Leu Thr Arg Gly Arg Lys Met Ala His Val 
1               5                   10                  15      


Ile Ala Ala Cys Leu Tyr Leu Val Cys Arg Thr Glu Gly Thr Pro His 
            20                  25                  30          


Met Leu Leu Asp Leu Ser Asp Leu Leu Gln Val Asn Val Tyr Val Leu 
        35                  40                  45              


Gly Lys Thr Phe Leu Leu Leu Ala Arg Glu Leu Cys Ile Asn Ala Pro 
    50                  55                  60                  


Ala Ile Asp Pro Cys Leu Tyr Ile Pro Arg Phe Ala His Leu Leu Glu 
65                  70                  75                  80  


Phe Gly Glu Lys Asn His Glu Val Ser Met Thr Ala Leu Arg Leu Leu 
                85                  90                  95      


Gln Arg Met Lys Arg Asp Trp Met His Thr Gly Arg Arg Pro Ser Gly 
            100                 105                 110         


Leu Cys Gly Ala Ala Leu Leu Val Ala Ala Arg Met His Asp Phe Arg 
        115                 120                 125             


Arg Thr Val Lys Glu Val Ile Ser Val Val Lys Val Cys Glu Ser Thr 
    130                 135                 140                 


Leu Arg Lys Arg Leu Thr Glu Phe Glu Asp Thr Pro Thr Ser Gln Leu 
145                 150                 155                 160 


Thr Ile Asp Glu Phe Met Lys Ile Asp Leu Glu Glu Glu Cys Asp Pro 
                165                 170                 175     


Pro Ser Tyr Thr Ala Gly Gln Arg Lys Leu Arg Met Lys Gln Leu Glu 
            180                 185                 190         


Gln Val Leu Ser Lys Lys Leu Glu Glu Val Glu Gly Glu Ile Ser Ser 
        195                 200                 205             


Tyr Gln Asp Ala Ile Glu Ile Glu Leu Glu Asn Ser Arg Pro Lys Ala 
    210                 215                 220                 


Lys Gly Gly Leu Ala Ser Leu Ala Lys Asp Gly Ser Thr Glu Asp Thr 
225                 230                 235                 240 


Ala Ser Ser Leu Cys Gly Glu Glu Asp Thr Glu Asp Glu Glu Leu Glu 
                245                 250                 255     


Ala Ala Ala Ser His Leu Asn Lys Asp Leu Tyr Arg Glu Leu Leu Gly 
            260                 265                 270         


Gly Ala Pro Gly Ser Ser Glu Ala Ala Gly Ser Pro Glu Trp Gly Gly 
        275                 280                 285             


Arg Pro Pro Ala Leu Gly Ser Leu Leu Asp Pro Leu Pro Thr Ala Ala 
    290                 295                 300                 


Ser Leu Gly Ile Ser Asp Ser Ile Arg Glu Cys Ile Ser Ser Gln Ser 
305                 310                 315                 320 


Ser Asp Pro Lys Asp Ala Ser Gly Asp Gly Glu Leu Asp Leu Ser Gly 
                325                 330                 335     


Ile Asp Asp Leu Glu Ile Asp Arg Tyr Ile Leu Asn Glu Ser Glu Ala 
            340                 345                 350         


Arg Val Lys Ala Glu Leu Trp Met Arg Glu Asn Ala Glu Tyr Leu Arg 
        355                 360                 365             


Glu Gln Arg Glu Lys Glu Ala Arg Ile Ala Lys Glu Lys Glu Leu Gly 
    370                 375                 380                 


Ile Tyr Lys Glu His Lys Pro Lys Lys Ser Cys Lys Arg Arg Glu Pro 
385                 390                 395                 400 


Ile Gln Ala Ser Thr Ala Arg Glu Ala Ile Glu Lys Met Leu Glu Gln 
                405                 410                 415     


Lys Lys Ile Ser Ser Lys Ile Asn Tyr Ser Val Leu Arg Gly Leu Ser 
            420                 425                 430         


Ser Ala Gly Gly Gly Ser Pro His Arg Glu Asp Ala Gln Pro Glu His 
        435                 440                 445             


Ser Ala Ser Ala Arg Lys Leu Ser Arg Arg Arg Thr Pro Ala Ser Arg 
    450                 455                 460                 


Ser Gly Ala Asp Pro Val Thr Ser Val Gly Lys Arg Leu Arg Pro Leu 
465                 470                 475                 480 


Val Ser Thr Gln Pro Ala Lys Lys Val Ala Thr Gly Glu Ala Leu Leu 
                485                 490                 495     


Pro Ser Ser Pro Thr Leu Gly Ala Glu Pro Ala Arg Pro Gln Ala Val 
            500                 505                 510         


Leu Val Glu Ser Gly Pro Val Ser Tyr His Ala Asp Glu Glu Ala Asp 
        515                 520                 525             


Glu Glu Glu Pro Asp Glu Glu Asp Gly Glu Pro Cys Val Ser Ala Leu 
    530                 535                 540                 


Gln Met Met Gly Ser Asn Asp Tyr Gly Cys Asp Gly Asp Glu Asp Asp 
545                 550                 555                 560 


Gly Tyr 
        


<210>  1560
<211>  584
<212>  PRT
<213>  Homo Sapiens

<400>  1560

Met Ala Val Ser Arg His Leu Thr Arg Gly Arg Lys Met Ala His Val 
1               5                   10                  15      


Ile Ala Ala Cys Leu Tyr Leu Val Cys Arg Thr Glu Gly Thr Pro His 
            20                  25                  30          


Met Leu Leu Asp Leu Ser Asp Leu Leu Gln Val Asn Val Tyr Val Leu 
        35                  40                  45              


Gly Lys Thr Phe Leu Leu Leu Ala Arg Glu Leu Cys Ile Asn Ala Pro 
    50                  55                  60                  


Ala Ile Asp Pro Cys Leu Tyr Ile Pro Arg Phe Ala His Leu Leu Glu 
65                  70                  75                  80  


Phe Gly Glu Lys Asn His Glu Val Ser Met Thr Ala Leu Arg Leu Leu 
                85                  90                  95      


Gln Arg Met Lys Arg Asp Trp Met His Thr Gly Arg Arg Pro Ser Gly 
            100                 105                 110         


Leu Cys Gly Ala Ala Leu Leu Val Ala Ala Arg Met His Asp Phe Arg 
        115                 120                 125             


Arg Thr Val Lys Glu Val Ile Ser Val Val Lys Val Cys Glu Ser Thr 
    130                 135                 140                 


Leu Arg Lys Arg Leu Thr Glu Phe Glu Asp Thr Pro Thr Ser Gln Leu 
145                 150                 155                 160 


Thr Ile Asp Glu Phe Met Lys Ile Asp Leu Glu Glu Glu Cys Asp Pro 
                165                 170                 175     


Pro Ser Tyr Thr Ala Gly Gln Arg Lys Leu Arg Met Lys Gln Leu Glu 
            180                 185                 190         


Gln Val Leu Ser Lys Lys Leu Glu Glu Val Glu Gly Glu Ile Ser Ser 
        195                 200                 205             


Tyr Gln Asp Ala Ile Glu Ile Glu Leu Glu Asn Ser Arg Pro Lys Ala 
    210                 215                 220                 


Lys Gly Gly Leu Ala Ser Leu Ala Lys Asp Gly Ser Thr Glu Asp Thr 
225                 230                 235                 240 


Ala Ser Ser Leu Cys Gly Glu Glu Asp Thr Glu Asp Glu Glu Leu Glu 
                245                 250                 255     


Ala Ala Ala Ser His Leu Asn Lys Asp Leu Tyr Arg Glu Leu Leu Gly 
            260                 265                 270         


Gly Ala Pro Gly Ser Ser Glu Ala Ala Gly Ser Pro Glu Trp Gly Gly 
        275                 280                 285             


Arg Pro Pro Ala Leu Gly Ser Leu Leu Asp Pro Leu Pro Thr Ala Ala 
    290                 295                 300                 


Ser Leu Gly Ile Ser Asp Ser Ile Arg Glu Cys Ile Ser Ser Gln Ser 
305                 310                 315                 320 


Ser Asp Pro Lys Asp Ala Ser Gly Asp Gly Glu Leu Asp Leu Ser Gly 
                325                 330                 335     


Ile Asp Asp Leu Glu Ile Asp Arg Arg Asp Leu Ser Met Pro Arg Cys 
            340                 345                 350         


Ala Lys Ala Lys Ser Gln Pro His Phe Pro Val Leu Ala Gln Tyr Ile 
        355                 360                 365             


Leu Asn Glu Ser Glu Ala Arg Val Lys Ala Glu Leu Trp Met Arg Glu 
    370                 375                 380                 


Asn Ala Glu Tyr Leu Arg Glu Gln Arg Glu Lys Glu Ala Arg Ile Ala 
385                 390                 395                 400 


Lys Glu Lys Glu Leu Gly Ile Tyr Lys Glu His Lys Pro Lys Lys Ser 
                405                 410                 415     


Cys Lys Arg Arg Glu Pro Ile Gln Ala Ser Thr Ala Arg Glu Ala Ile 
            420                 425                 430         


Glu Lys Met Leu Glu Gln Lys Lys Ile Ser Ser Lys Ile Asn Tyr Ser 
        435                 440                 445             


Val Leu Arg Gly Leu Ser Ser Ala Gly Gly Gly Ser Pro His Arg Glu 
    450                 455                 460                 


Asp Ala Gln Pro Glu His Ser Ala Ser Ala Arg Lys Leu Ser Arg Arg 
465                 470                 475                 480 


Arg Thr Pro Ala Ser Arg Ser Gly Ala Asp Pro Val Thr Ser Val Gly 
                485                 490                 495     


Lys Arg Leu Arg Pro Leu Val Ser Thr Gln Pro Ala Lys Lys Val Ala 
            500                 505                 510         


Thr Gly Glu Ala Leu Leu Pro Ser Ser Pro Thr Leu Gly Ala Glu Pro 
        515                 520                 525             


Ala Arg Pro Gln Ala Val Leu Val Glu Ser Gly Pro Val Ser Tyr His 
    530                 535                 540                 


Ala Asp Glu Glu Ala Asp Glu Glu Glu Pro Asp Glu Glu Asp Gly Glu 
545                 550                 555                 560 


Pro Cys Val Ser Ala Leu Gln Met Met Gly Ser Asn Asp Tyr Gly Cys 
                565                 570                 575     


Asp Gly Asp Glu Asp Asp Gly Tyr 
            580                 


<210>  1561
<211>  439
<212>  PRT
<213>  Homo Sapiens

<400>  1561

Met His Asp Phe Arg Arg Thr Val Lys Glu Val Ile Ser Val Val Lys 
1               5                   10                  15      


Val Cys Glu Ser Thr Leu Arg Lys Arg Leu Thr Glu Phe Glu Asp Thr 
            20                  25                  30          


Pro Thr Ser Gln Leu Thr Ile Asp Glu Phe Met Lys Ile Asp Leu Glu 
        35                  40                  45              


Glu Glu Cys Asp Pro Pro Ser Tyr Thr Ala Gly Gln Arg Lys Leu Arg 
    50                  55                  60                  


Met Lys Gln Leu Glu Gln Val Leu Ser Lys Lys Leu Glu Glu Val Glu 
65                  70                  75                  80  


Gly Glu Ile Ser Ser Tyr Gln Asp Ala Ile Glu Ile Glu Leu Glu Asn 
                85                  90                  95      


Ser Arg Pro Lys Ala Lys Gly Gly Leu Ala Ser Leu Ala Lys Asp Gly 
            100                 105                 110         


Ser Thr Glu Asp Thr Ala Ser Ser Leu Cys Gly Glu Glu Asp Thr Glu 
        115                 120                 125             


Asp Glu Glu Leu Glu Ala Ala Ala Ser His Leu Asn Lys Asp Leu Tyr 
    130                 135                 140                 


Arg Glu Leu Leu Gly Gly Ala Pro Gly Ser Ser Glu Ala Ala Gly Ser 
145                 150                 155                 160 


Pro Glu Trp Gly Gly Arg Pro Pro Ala Leu Gly Ser Leu Leu Asp Pro 
                165                 170                 175     


Leu Pro Thr Ala Ala Ser Leu Gly Ile Ser Asp Ser Ile Arg Glu Cys 
            180                 185                 190         


Ile Ser Ser Gln Ser Ser Asp Pro Lys Asp Ala Ser Gly Asp Gly Glu 
        195                 200                 205             


Leu Asp Leu Ser Gly Ile Asp Asp Leu Glu Ile Asp Arg Tyr Ile Leu 
    210                 215                 220                 


Asn Glu Ser Glu Ala Arg Val Lys Ala Glu Leu Trp Met Arg Glu Asn 
225                 230                 235                 240 


Ala Glu Tyr Leu Arg Glu Gln Arg Glu Lys Glu Ala Arg Ile Ala Lys 
                245                 250                 255     


Glu Lys Glu Leu Gly Ile Tyr Lys Glu His Lys Pro Lys Lys Ser Cys 
            260                 265                 270         


Lys Arg Arg Glu Pro Ile Gln Ala Ser Thr Ala Arg Glu Ala Ile Glu 
        275                 280                 285             


Lys Met Leu Glu Gln Lys Lys Ile Ser Ser Lys Ile Asn Tyr Ser Val 
    290                 295                 300                 


Leu Arg Gly Leu Ser Ser Ala Gly Gly Gly Ser Pro His Arg Glu Asp 
305                 310                 315                 320 


Ala Gln Pro Glu His Ser Ala Ser Ala Arg Lys Leu Ser Arg Arg Arg 
                325                 330                 335     


Thr Pro Ala Ser Arg Ser Gly Ala Asp Pro Val Thr Ser Val Gly Lys 
            340                 345                 350         


Arg Leu Arg Pro Leu Val Ser Thr Gln Pro Ala Lys Lys Val Ala Thr 
        355                 360                 365             


Gly Glu Ala Leu Leu Pro Ser Ser Pro Thr Leu Gly Ala Glu Pro Ala 
    370                 375                 380                 


Arg Pro Gln Ala Val Leu Val Glu Ser Gly Pro Val Ser Tyr His Ala 
385                 390                 395                 400 


Asp Glu Glu Ala Asp Glu Glu Glu Pro Asp Glu Glu Asp Gly Glu Pro 
                405                 410                 415     


Cys Val Ser Ala Leu Gln Met Met Gly Ser Asn Asp Tyr Gly Cys Asp 
            420                 425                 430         


Gly Asp Glu Asp Asp Gly Tyr 
        435                 


<210>  1562
<211>  14
<212>  PRT
<213>  Homo Sapiens

<400>  1562

Met Thr Ala Leu Arg Leu Leu Gln Arg Met Lys Arg Asp Trp 
1               5                   10                  


<210>  1563
<211>  45
<212>  PRT
<213>  Homo Sapiens

<400>  1563

Met Thr Ala Leu Arg Leu Leu Gln Arg Met Lys Arg Asp Trp Met His 
1               5                   10                  15      


Thr Gly Arg Arg Pro Ser Gly Leu Cys Gly Ala Ala Leu Leu Val Ala 
            20                  25                  30          


Ala Arg Met His Asp Phe Arg Arg Thr Val Lys Glu Val 
        35                  40                  45  


<210>  1564
<211>  134
<212>  PRT
<213>  Homo Sapiens

<400>  1564

Met Thr Ala Leu Arg Leu Leu Gln Arg Met Lys Arg Asp Trp Met His 
1               5                   10                  15      


Thr Gly Arg Arg Pro Ser Gly Leu Cys Gly Ala Ala Leu Leu Val Ala 
            20                  25                  30          


Ala Arg Met His Asp Phe Arg Arg Thr Val Lys Glu Val Ile Ser Val 
        35                  40                  45              


Val Lys Val Cys Glu Ser Thr Leu Arg Lys Arg Leu Thr Glu Phe Glu 
    50                  55                  60                  


Asp Thr Pro Thr Ser Gln Leu Thr Ile Asp Glu Phe Met Lys Ile Asp 
65                  70                  75                  80  


Leu Glu Glu Glu Cys Asp Pro Pro Ser Glu Glu Gly Gly Gln Thr Glu 
                85                  90                  95      


Ala Arg Glu Pro Pro Gln Ala Ser Ser Trp Glu Gly Pro Ser Thr Thr 
            100                 105                 110         


Arg Arg Arg Ser Gln Leu Trp His Gly Cys Pro Gly Cys Gly Arg Gly 
        115                 120                 125             


Gly Phe Thr Leu Cys Pro 
    130                 


<210>  1565
<211>  184
<212>  PRT
<213>  Homo Sapiens

<400>  1565

Met Thr Ala Leu Arg Leu Leu Gln Arg Met Lys Arg Asp Trp Met His 
1               5                   10                  15      


Thr Gly Arg Arg Pro Ser Gly Leu Cys Gly Ala Ala Leu Leu Val Ala 
            20                  25                  30          


Ala Arg Met His Asp Phe Arg Arg Thr Val Lys Glu Val Ile Ser Val 
        35                  40                  45              


Val Lys Val Cys Glu Ser Thr Leu Arg Lys Arg Leu Thr Glu Phe Glu 
    50                  55                  60                  


Asp Thr Pro Thr Ser Gln Leu Thr Ile Asp Glu Phe Met Lys Ile Asp 
65                  70                  75                  80  


Leu Glu Glu Glu Cys Asp Pro Pro Ser Tyr Thr Ala Gly Gln Arg Lys 
                85                  90                  95      


Leu Arg Met Lys Gln Leu Glu Gln Val Leu Ser Lys Lys Leu Glu Glu 
            100                 105                 110         


Val Glu Gly Glu Ile Ser Ser Tyr Gln Asp Ala Ile Glu Ile Glu Leu 
        115                 120                 125             


Glu Asn Ser Pro Pro Ser Arg Arg Glu Gly Arg Arg Arg Pro Glu Ser 
    130                 135                 140                 


Leu Pro Arg Pro Leu Arg Gly Lys Ala Pro Val Pro Leu Val Gly Gly 
145                 150                 155                 160 


Leu Ser Ser Gly Met Ala Ala Pro Asp Val Ala Glu Gly Ala Ser Pro 
                165                 170                 175     


Cys Val Leu Arg Arg Gly Trp Pro 
            180                 


<210>  1566
<211>  155
<212>  PRT
<213>  Homo Sapiens

<400>  1566

Met Thr Ala Leu Arg Leu Leu Gln Arg Met Lys Arg Asp Trp Met His 
1               5                   10                  15      


Thr Gly Arg Arg Pro Ser Gly Leu Cys Gly Ala Ala Leu Leu Val Ala 
            20                  25                  30          


Ala Arg Met His Asp Phe Arg Arg Thr Val Lys Glu Val Ile Ser Val 
        35                  40                  45              


Val Lys Val Cys Glu Ser Thr Leu Arg Lys Arg Leu Thr Glu Phe Glu 
    50                  55                  60                  


Asp Thr Pro Thr Ser Gln Leu Thr Ile Asp Glu Phe Met Lys Ile Asp 
65                  70                  75                  80  


Leu Glu Glu Glu Cys Asp Pro Pro Ser Tyr Thr Ala Gly Gln Arg Lys 
                85                  90                  95      


Leu Arg Met Lys Gln Leu Glu Gln Val Leu Ser Lys Lys Leu Glu Glu 
            100                 105                 110         


Val Glu Gly Glu Ile Ser Ser Tyr Gln Asp Ala Ile Glu Ile Glu Leu 
        115                 120                 125             


Glu Asn Ser Arg Pro Lys Ala Lys Gly Gly Leu Ala Ser Leu Ala Lys 
    130                 135                 140                 


Asp Gly Ser Thr Glu Asp Thr Ala Ser Ser Leu 
145                 150                 155 


<210>  1567
<211>  234
<212>  PRT
<213>  Homo Sapiens

<400>  1567

Met Thr Ala Leu Arg Leu Leu Gln Arg Met Lys Arg Asp Trp Met His 
1               5                   10                  15      


Thr Gly Arg Arg Pro Ser Gly Leu Cys Gly Ala Ala Leu Leu Val Ala 
            20                  25                  30          


Ala Arg Met His Asp Phe Arg Arg Thr Val Lys Glu Val Ile Ser Val 
        35                  40                  45              


Val Lys Val Cys Glu Ser Thr Leu Arg Lys Arg Leu Thr Glu Phe Glu 
    50                  55                  60                  


Asp Thr Pro Thr Ser Gln Leu Thr Ile Asp Glu Phe Met Lys Ile Asp 
65                  70                  75                  80  


Leu Glu Glu Glu Cys Asp Pro Pro Ser Tyr Thr Ala Gly Gln Arg Lys 
                85                  90                  95      


Leu Arg Met Lys Gln Leu Glu Gln Val Leu Ser Lys Lys Leu Glu Glu 
            100                 105                 110         


Val Glu Gly Glu Ile Ser Ser Tyr Gln Asp Ala Ile Glu Ile Glu Leu 
        115                 120                 125             


Glu Asn Ser Arg Pro Lys Ala Lys Gly Gly Leu Ala Ser Leu Ala Lys 
    130                 135                 140                 


Asp Gly Ser Thr Glu Asp Thr Ala Ser Ser Leu Cys Gly Glu Glu Asp 
145                 150                 155                 160 


Thr Glu Asp Glu Glu Leu Glu Ala Ala Ala Ser His Leu Asn Lys Asp 
                165                 170                 175     


Leu Tyr Arg Glu Leu Leu Gly Gly Ala Pro Gly Ser Ser Glu Ala Ala 
            180                 185                 190         


Gly Ser Pro Glu Trp Gly Gly Arg Pro Pro Ala Leu Gly Ser Leu Leu 
        195                 200                 205             


Asp Pro Leu Pro Thr Ala Ala Ser Leu Gly Ile Ser Asp Ser Ile Arg 
    210                 215                 220                 


Glu Cys Ile Ser Ser Gln Ser Ser Asp Pro 
225                 230                 


<210>  1568
<211>  473
<212>  PRT
<213>  Homo Sapiens

<400>  1568

Met Thr Ala Leu Arg Leu Leu Gln Arg Met Lys Arg Asp Trp Met His 
1               5                   10                  15      


Thr Gly Arg Arg Pro Ser Gly Leu Cys Gly Ala Ala Leu Leu Val Ala 
            20                  25                  30          


Ala Arg Met His Asp Phe Arg Arg Thr Val Lys Glu Val Ile Ser Val 
        35                  40                  45              


Val Lys Val Cys Glu Ser Thr Leu Arg Lys Arg Leu Thr Glu Phe Glu 
    50                  55                  60                  


Asp Thr Pro Thr Ser Gln Leu Thr Ile Asp Glu Phe Met Lys Ile Asp 
65                  70                  75                  80  


Leu Glu Glu Glu Cys Asp Pro Pro Ser Tyr Thr Ala Gly Gln Arg Lys 
                85                  90                  95      


Leu Arg Met Lys Gln Leu Glu Gln Val Leu Ser Lys Lys Leu Glu Glu 
            100                 105                 110         


Val Glu Gly Glu Ile Ser Ser Tyr Gln Asp Ala Ile Glu Ile Glu Leu 
        115                 120                 125             


Glu Asn Ser Arg Pro Lys Ala Lys Gly Gly Leu Ala Ser Leu Ala Lys 
    130                 135                 140                 


Asp Gly Ser Thr Glu Asp Thr Ala Ser Ser Leu Cys Gly Glu Glu Asp 
145                 150                 155                 160 


Thr Glu Asp Glu Glu Leu Glu Ala Ala Ala Ser His Leu Asn Lys Asp 
                165                 170                 175     


Leu Tyr Arg Glu Leu Leu Gly Gly Ala Pro Gly Ser Ser Glu Ala Ala 
            180                 185                 190         


Gly Ser Pro Glu Trp Gly Gly Arg Pro Pro Ala Leu Gly Ser Leu Leu 
        195                 200                 205             


Asp Pro Leu Pro Thr Ala Ala Ser Leu Gly Ile Ser Asp Ser Ile Arg 
    210                 215                 220                 


Glu Cys Ile Ser Ser Gln Ser Ser Asp Pro Lys Asp Ala Ser Gly Asp 
225                 230                 235                 240 


Gly Glu Leu Asp Leu Ser Gly Ile Asp Asp Leu Glu Ile Asp Arg Tyr 
                245                 250                 255     


Ile Leu Asn Glu Ser Glu Ala Arg Val Lys Ala Glu Leu Trp Met Arg 
            260                 265                 270         


Glu Asn Ala Glu Tyr Leu Arg Glu Gln Arg Glu Lys Glu Ala Arg Ile 
        275                 280                 285             


Ala Lys Glu Lys Glu Leu Gly Ile Tyr Lys Glu His Lys Pro Lys Lys 
    290                 295                 300                 


Ser Cys Lys Arg Arg Glu Pro Ile Gln Ala Ser Thr Ala Arg Glu Ala 
305                 310                 315                 320 


Ile Glu Lys Met Leu Glu Gln Lys Lys Ile Ser Ser Lys Ile Asn Tyr 
                325                 330                 335     


Ser Val Leu Arg Gly Leu Ser Ser Ala Gly Gly Gly Ser Pro His Arg 
            340                 345                 350         


Glu Asp Ala Gln Pro Glu His Ser Ala Ser Ala Arg Lys Leu Ser Arg 
        355                 360                 365             


Arg Arg Thr Pro Ala Ser Arg Ser Gly Ala Asp Pro Val Thr Ser Val 
    370                 375                 380                 


Gly Lys Arg Leu Arg Pro Leu Val Ser Thr Gln Pro Ala Lys Lys Val 
385                 390                 395                 400 


Ala Thr Gly Glu Ala Leu Leu Pro Ser Ser Pro Thr Leu Gly Ala Glu 
                405                 410                 415     


Pro Ala Arg Pro Gln Ala Val Leu Val Glu Ser Gly Pro Val Ser Tyr 
            420                 425                 430         


His Ala Asp Glu Glu Ala Asp Glu Glu Glu Pro Asp Glu Glu Asp Gly 
        435                 440                 445             


Glu Pro Cys Val Ser Ala Leu Gln Met Met Gly Ser Asn Asp Tyr Gly 
    450                 455                 460                 


Cys Asp Gly Asp Glu Asp Asp Gly Tyr 
465                 470             


<210>  1569
<211>  161
<212>  PRT
<213>  Homo Sapiens

<400>  1569

Met Thr Ala Leu Arg Leu Leu Gln Arg Met Lys Arg Asp Trp Met His 
1               5                   10                  15      


Thr Gly Arg Arg Pro Ser Gly Leu Cys Gly Ala Ala Leu Leu Val Ala 
            20                  25                  30          


Ala Arg Met His Asp Phe Arg Arg Thr Val Lys Glu Val Ile Ser Val 
        35                  40                  45              


Val Lys Val Cys Glu Ser Thr Leu Arg Lys Arg Leu Thr Glu Phe Glu 
    50                  55                  60                  


Asp Thr Pro Thr Ser Gln Leu Thr Ile Asp Glu Phe Met Lys Ile Asp 
65                  70                  75                  80  


Leu Glu Glu Glu Cys Asp Pro Pro Ser Tyr Thr Ala Gly Gln Arg Lys 
                85                  90                  95      


Leu Arg Met Lys Gln Leu Glu Gln Val Leu Ser Lys Lys Leu Glu Glu 
            100                 105                 110         


Val Glu Gly Glu Ile Ser Ser Tyr Gln Asp Ala Ile Glu Ile Glu Leu 
        115                 120                 125             


Glu Asn Ser Arg Pro Lys Ala Pro His Arg Gly Gly Arg Ala Asp Gly 
    130                 135                 140                 


Gly Pro Arg Ala Ser Pro Gly Leu Phe Val Gly Arg Pro Gln Tyr His 
145                 150                 155                 160 


Ser 
    


<210>  1570
<211>  208
<212>  PRT
<213>  Homo Sapiens

<400>  1570

Met Thr Gly Arg Val Cys Arg Gly Cys Gly Gly Thr Asp Ile Glu Leu 
1               5                   10                  15      


Asp Ala Ala Arg Gly Asp Ala Val Cys Thr Ala Cys Gly Ser Val Leu 
            20                  25                  30          


Glu Asp Asn Ile Ile Val Ser Glu Val Gln Phe Val Glu Ser Ser Gly 
        35                  40                  45              


Gly Gly Ser Ser Ala Val Gly Gln Phe Val Ser Leu Asp Gly Ala Gly 
    50                  55                  60                  


Lys Thr Pro Thr Leu Gly Gly Gly Phe His Val Asn Leu Gly Lys Glu 
65                  70                  75                  80  


Ser Arg Ala Gln Thr Leu Gln Asn Gly Arg Arg His Ile His His Leu 
                85                  90                  95      


Gly Asn Gln Leu Gln Leu Asn Gln His Cys Leu Asp Thr Ala Phe Asn 
            100                 105                 110         


Phe Phe Lys Met Ala Val Ser Arg His Leu Thr Arg Gly Arg Lys Met 
        115                 120                 125             


Ala His Val Ile Ala Ala Cys Leu Tyr Leu Val Cys Arg Thr Glu Gly 
    130                 135                 140                 


Thr Pro His Met Leu Leu Asp Leu Ser Asp Leu Leu Gln Val Asp Ser 
145                 150                 155                 160 


Leu Arg Pro Ala Ser Phe Pro Thr Trp Gly Cys Asp Leu Gly Val Val 
                165                 170                 175     


Thr Arg Val Val Thr Gly Val Tyr Pro Arg Cys Leu His Ala Ser Gln 
            180                 185                 190         


Trp Pro Val Cys Ala Ala Cys Pro Val Arg Lys Phe Trp Ser Val Gly 
        195                 200                 205             


<210>  1571
<211>  677
<212>  PRT
<213>  Homo Sapiens

<400>  1571

Met Thr Gly Arg Val Cys Arg Gly Cys Gly Gly Thr Asp Ile Glu Leu 
1               5                   10                  15      


Asp Ala Ala Arg Gly Asp Ala Val Cys Thr Ala Cys Gly Ser Val Leu 
            20                  25                  30          


Glu Asp Asn Ile Ile Val Ser Glu Val Gln Phe Val Glu Ser Ser Gly 
        35                  40                  45              


Gly Gly Ser Ser Ala Val Gly Gln Phe Val Ser Leu Asp Gly Ala Gly 
    50                  55                  60                  


Lys Thr Pro Thr Leu Gly Gly Gly Phe His Val Asn Leu Gly Lys Glu 
65                  70                  75                  80  


Ser Arg Ala Gln Thr Leu Gln Asn Gly Arg Arg His Ile His His Leu 
                85                  90                  95      


Gly Asn Gln Leu Gln Leu Asn Gln His Cys Leu Asp Thr Ala Phe Asn 
            100                 105                 110         


Phe Phe Lys Met Ala Val Ser Arg His Leu Thr Arg Gly Arg Lys Met 
        115                 120                 125             


Ala His Val Ile Ala Ala Cys Leu Tyr Leu Val Cys Arg Thr Glu Gly 
    130                 135                 140                 


Thr Pro His Met Leu Leu Asp Leu Ser Asp Leu Leu Gln Val Asn Val 
145                 150                 155                 160 


Tyr Val Leu Gly Lys Thr Phe Leu Leu Leu Ala Arg Glu Leu Cys Ile 
                165                 170                 175     


Asn Ala Pro Ala Ile Asp Pro Cys Leu Tyr Ile Pro Arg Phe Ala His 
            180                 185                 190         


Leu Leu Glu Phe Gly Glu Lys Asn His Glu Val Ser Met Thr Ala Leu 
        195                 200                 205             


Arg Leu Leu Gln Arg Met Lys Arg Asp Trp Met His Thr Gly Arg Arg 
    210                 215                 220                 


Pro Ser Gly Leu Cys Gly Ala Ala Leu Leu Val Ala Ala Arg Met His 
225                 230                 235                 240 


Asp Phe Arg Arg Thr Val Lys Glu Val Ile Ser Val Val Lys Val Cys 
                245                 250                 255     


Glu Ser Thr Leu Arg Lys Arg Leu Thr Glu Phe Glu Asp Thr Pro Thr 
            260                 265                 270         


Ser Gln Leu Thr Ile Asp Glu Phe Met Lys Ile Asp Leu Glu Glu Glu 
        275                 280                 285             


Cys Asp Pro Pro Ser Tyr Thr Ala Gly Gln Arg Lys Leu Arg Met Lys 
    290                 295                 300                 


Gln Leu Glu Gln Val Leu Ser Lys Lys Leu Glu Glu Val Glu Gly Glu 
305                 310                 315                 320 


Ile Ser Ser Tyr Gln Asp Ala Ile Glu Ile Glu Leu Glu Asn Ser Arg 
                325                 330                 335     


Pro Lys Ala Lys Gly Gly Leu Ala Ser Leu Ala Lys Asp Gly Ser Thr 
            340                 345                 350         


Glu Asp Thr Ala Ser Ser Leu Cys Gly Glu Glu Asp Thr Glu Asp Glu 
        355                 360                 365             


Glu Leu Glu Ala Ala Ala Ser His Leu Asn Lys Asp Leu Tyr Arg Glu 
    370                 375                 380                 


Leu Leu Gly Gly Ala Pro Gly Ser Ser Glu Ala Ala Gly Ser Pro Glu 
385                 390                 395                 400 


Trp Gly Gly Arg Pro Pro Ala Leu Gly Ser Leu Leu Asp Pro Leu Pro 
                405                 410                 415     


Thr Ala Ala Ser Leu Gly Ile Ser Asp Ser Ile Arg Glu Cys Ile Ser 
            420                 425                 430         


Ser Gln Ser Ser Asp Pro Lys Asp Ala Ser Gly Asp Gly Glu Leu Asp 
        435                 440                 445             


Leu Ser Gly Ile Asp Asp Leu Glu Ile Asp Arg Tyr Ile Leu Asn Glu 
    450                 455                 460                 


Ser Glu Ala Arg Val Lys Ala Glu Leu Trp Met Arg Glu Asn Ala Glu 
465                 470                 475                 480 


Tyr Leu Arg Glu Gln Arg Glu Lys Glu Ala Arg Ile Ala Lys Glu Lys 
                485                 490                 495     


Glu Leu Gly Ile Tyr Lys Glu His Lys Pro Lys Lys Ser Cys Lys Arg 
            500                 505                 510         


Arg Glu Pro Ile Gln Ala Ser Thr Ala Arg Glu Ala Ile Glu Lys Met 
        515                 520                 525             


Leu Glu Gln Lys Lys Ile Ser Ser Lys Ile Asn Tyr Ser Val Leu Arg 
    530                 535                 540                 


Gly Leu Ser Ser Ala Gly Gly Gly Ser Pro His Arg Glu Asp Ala Gln 
545                 550                 555                 560 


Pro Glu His Ser Ala Ser Ala Arg Lys Leu Ser Arg Arg Arg Thr Pro 
                565                 570                 575     


Ala Ser Arg Ser Gly Ala Asp Pro Val Thr Ser Val Gly Lys Arg Leu 
            580                 585                 590         


Arg Pro Leu Val Ser Thr Gln Pro Ala Lys Lys Val Ala Thr Gly Glu 
        595                 600                 605             


Ala Leu Leu Pro Ser Ser Pro Thr Leu Gly Ala Glu Pro Ala Arg Pro 
    610                 615                 620                 


Gln Ala Val Leu Val Glu Ser Gly Pro Val Ser Tyr His Ala Asp Glu 
625                 630                 635                 640 


Glu Ala Asp Glu Glu Glu Pro Asp Glu Glu Asp Gly Glu Pro Cys Val 
                645                 650                 655     


Ser Ala Leu Gln Met Met Gly Ser Asn Asp Tyr Gly Cys Asp Gly Asp 
            660                 665                 670         


Glu Asp Asp Gly Tyr 
        675         


<210>  1572
<211>  650
<212>  PRT
<213>  Homo Sapiens

<400>  1572

Met Thr Gly Arg Val Cys Arg Gly Cys Gly Gly Thr Asp Ile Glu Leu 
1               5                   10                  15      


Asp Ala Ala Arg Gly Asp Ala Val Cys Thr Ala Cys Gly Ser Val Leu 
            20                  25                  30          


Glu Asp Asn Ile Ile Val Ser Glu Val Gln Phe Val Glu Ser Ser Gly 
        35                  40                  45              


Gly Gly Ser Ser Ala Val Gly Gln Phe Val Ser Leu Asp Gly Arg Arg 
    50                  55                  60                  


His Ile His His Leu Gly Asn Gln Leu Gln Leu Asn Gln His Cys Leu 
65                  70                  75                  80  


Asp Thr Ala Phe Asn Phe Phe Lys Met Ala Val Ser Arg His Leu Thr 
                85                  90                  95      


Arg Gly Arg Lys Met Ala His Val Ile Ala Ala Cys Leu Tyr Leu Val 
            100                 105                 110         


Cys Arg Thr Glu Gly Thr Pro His Met Leu Leu Asp Leu Ser Asp Leu 
        115                 120                 125             


Leu Gln Val Asn Val Tyr Val Leu Gly Lys Thr Phe Leu Leu Leu Ala 
    130                 135                 140                 


Arg Glu Leu Cys Ile Asn Ala Pro Ala Ile Asp Pro Cys Leu Tyr Ile 
145                 150                 155                 160 


Pro Arg Phe Ala His Leu Leu Glu Phe Gly Glu Lys Asn His Glu Val 
                165                 170                 175     


Ser Met Thr Ala Leu Arg Leu Leu Gln Arg Met Lys Arg Asp Trp Met 
            180                 185                 190         


His Thr Gly Arg Arg Pro Ser Gly Leu Cys Gly Ala Ala Leu Leu Val 
        195                 200                 205             


Ala Ala Arg Met His Asp Phe Arg Arg Thr Val Lys Glu Val Ile Ser 
    210                 215                 220                 


Val Val Lys Val Cys Glu Ser Thr Leu Arg Lys Arg Leu Thr Glu Phe 
225                 230                 235                 240 


Glu Asp Thr Pro Thr Ser Gln Leu Thr Ile Asp Glu Phe Met Lys Ile 
                245                 250                 255     


Asp Leu Glu Glu Glu Cys Asp Pro Pro Ser Tyr Thr Ala Gly Gln Arg 
            260                 265                 270         


Lys Leu Arg Met Lys Gln Leu Glu Gln Val Leu Ser Lys Lys Leu Glu 
        275                 280                 285             


Glu Val Glu Gly Glu Ile Ser Ser Tyr Gln Asp Ala Ile Glu Ile Glu 
    290                 295                 300                 


Leu Glu Asn Ser Arg Pro Lys Ala Lys Gly Gly Leu Ala Ser Leu Ala 
305                 310                 315                 320 


Lys Asp Gly Ser Thr Glu Asp Thr Ala Ser Ser Leu Cys Gly Glu Glu 
                325                 330                 335     


Asp Thr Glu Asp Glu Glu Leu Glu Ala Ala Ala Ser His Leu Asn Lys 
            340                 345                 350         


Asp Leu Tyr Arg Glu Leu Leu Gly Gly Ala Pro Gly Ser Ser Glu Ala 
        355                 360                 365             


Ala Gly Ser Pro Glu Trp Gly Gly Arg Pro Pro Ala Leu Gly Ser Leu 
    370                 375                 380                 


Leu Asp Pro Leu Pro Thr Ala Ala Ser Leu Gly Ile Ser Asp Ser Ile 
385                 390                 395                 400 


Arg Glu Cys Ile Ser Ser Gln Ser Ser Asp Pro Lys Asp Ala Ser Gly 
                405                 410                 415     


Asp Gly Glu Leu Asp Leu Ser Gly Ile Asp Asp Leu Glu Ile Asp Arg 
            420                 425                 430         


Tyr Ile Leu Asn Glu Ser Glu Ala Arg Val Lys Ala Glu Leu Trp Met 
        435                 440                 445             


Arg Glu Asn Ala Glu Tyr Leu Arg Glu Gln Arg Glu Lys Glu Ala Arg 
    450                 455                 460                 


Ile Ala Lys Glu Lys Glu Leu Gly Ile Tyr Lys Glu His Lys Pro Lys 
465                 470                 475                 480 


Lys Ser Cys Lys Arg Arg Glu Pro Ile Gln Ala Ser Thr Ala Arg Glu 
                485                 490                 495     


Ala Ile Glu Lys Met Leu Glu Gln Lys Lys Ile Ser Ser Lys Ile Asn 
            500                 505                 510         


Tyr Ser Val Leu Arg Gly Leu Ser Ser Ala Gly Gly Gly Ser Pro His 
        515                 520                 525             


Arg Glu Asp Ala Gln Pro Glu His Ser Ala Ser Ala Arg Lys Leu Ser 
    530                 535                 540                 


Arg Arg Arg Thr Pro Ala Ser Arg Ser Gly Ala Asp Pro Val Thr Ser 
545                 550                 555                 560 


Val Gly Lys Arg Leu Arg Pro Leu Val Ser Thr Gln Pro Ala Lys Lys 
                565                 570                 575     


Val Ala Thr Gly Glu Ala Leu Leu Pro Ser Ser Pro Thr Leu Gly Ala 
            580                 585                 590         


Glu Pro Ala Arg Pro Gln Ala Val Leu Val Glu Ser Gly Pro Val Ser 
        595                 600                 605             


Tyr His Ala Asp Glu Glu Ala Asp Glu Glu Glu Pro Asp Glu Glu Asp 
    610                 615                 620                 


Gly Glu Pro Cys Val Ser Ala Leu Gln Met Met Gly Ser Asn Asp Tyr 
625                 630                 635                 640 


Gly Cys Asp Gly Asp Glu Asp Asp Gly Tyr 
                645                 650 


<210>  1573
<211>  185
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1573

Xaa Gly Gln Phe Val Ser Leu Asp Gly Ala Gly Lys Thr Pro Thr Leu 
1               5                   10                  15      


Gly Gly Gly Phe His Val Asn Leu Gly Lys Glu Ser Arg Ala Gln Thr 
            20                  25                  30          


Leu Gln Asn Asp Pro Cys Leu Tyr Ile Pro Arg Phe Ala His Leu Leu 
        35                  40                  45              


Glu Phe Gly Glu Lys Asn His Glu Val Ser Met Thr Ala Leu Arg Leu 
    50                  55                  60                  


Leu Gln Arg Met Lys Arg Asp Trp Met His Thr Gly Arg Arg Pro Ser 
65                  70                  75                  80  


Gly Leu Cys Gly Ala Ala Leu Leu Val Ala Ala Arg Met His Asp Phe 
                85                  90                  95      


Arg Arg Thr Val Lys Glu Val Ile Ser Val Val Lys Val Cys Glu Ser 
            100                 105                 110         


Thr Leu Arg Lys Arg Leu Thr Glu Phe Glu Asp Thr Pro Thr Ser Gln 
        115                 120                 125             


Leu Thr Ile Asp Glu Phe Met Lys Ile Asp Leu Glu Glu Glu Cys Asp 
    130                 135                 140                 


Pro Pro Ser Tyr Thr Ala Gly Gln Arg Lys Leu Arg Met Lys Gln Leu 
145                 150                 155                 160 


Glu Gln Val Leu Ser Lys Lys Leu Glu Glu Val Glu Gly Glu Ile Ser 
                165                 170                 175     


Ser Tyr Gln Asp Ala Ile Glu Ile Glu 
            180                 185 


<210>  1574
<211>  761
<212>  PRT
<213>  Homo Sapiens

<400>  1574

Met Asn Trp Arg Phe Val Glu Leu Leu Tyr Phe Leu Phe Ile Trp Gly 
1               5                   10                  15      


Arg Ile Ser Val Gln Pro Ser His Gln Glu Pro Ala Gly Thr Asp Gln 
            20                  25                  30          


His Val Ser Lys Glu Phe Asp Trp Leu Ile Ser Asp Arg Gly Pro Phe 
        35                  40                  45              


His His Ser Arg Ser Tyr Leu Ser Phe Val Glu Arg His Arg Gln Gly 
    50                  55                  60                  


Phe Thr Thr Arg Tyr Lys Ile Tyr Arg Glu Phe Ala Arg Trp Lys Val 
65                  70                  75                  80  


Arg Asn Thr Ala Ile Glu Arg Arg Asp Leu Val Arg His Pro Val Pro 
                85                  90                  95      


Leu Met Pro Glu Phe Gln Arg Ser Ile Arg Leu Leu Gly Arg Arg Pro 
            100                 105                 110         


Thr Thr Gln Gln Phe Ile Asp Thr Ile Ile Lys Lys Tyr Gly Thr His 
        115                 120                 125             


Leu Leu Ile Ser Ala Thr Leu Gly Gly Glu Glu Ala Leu Thr Met Tyr 
    130                 135                 140                 


Met Asp Lys Ser Arg Leu Asp Arg Lys Ser Gly Asn Ala Thr Gln Ser 
145                 150                 155                 160 


Val Glu Ala Leu His Gln Leu Ala Ser Ser Tyr Phe Val Asp Arg Asp 
                165                 170                 175     


Gly Thr Met Arg Arg Leu His Glu Ile Gln Ile Ser Thr Gly Ala Ile 
            180                 185                 190         


Lys Val Thr Glu Thr Arg Thr Gly Pro Leu Gly Cys Asn Ser Tyr Asp 
        195                 200                 205             


Asn Leu Asp Ser Val Ser Ser Val Leu Leu Gln Ser Thr Glu Ser Lys 
    210                 215                 220                 


Leu His Leu Gln Gly Leu Gln Ile Ile Phe Pro Gln Tyr Leu Gln Glu 
225                 230                 235                 240 


Lys Phe Val Gln Ser Ala Leu Ser Tyr Ile Met Cys Asn Gly Glu Gly 
                245                 250                 255     


Glu Tyr Leu Cys Gln Asn Ser Gln Cys Arg Cys Gln Cys Ala Glu Glu 
            260                 265                 270         


Phe Pro Gln Cys Asn Cys Pro Ile Thr Asp Ile Gln Ile Met Glu Tyr 
        275                 280                 285             


Thr Leu Ala Asn Met Ala Lys Ser Trp Ala Glu Ala Tyr Lys Asp Leu 
    290                 295                 300                 


Glu Asn Ser Asp Glu Phe Lys Ser Phe Met Lys Arg Leu Pro Ser Asn 
305                 310                 315                 320 


His Phe Leu Thr Ile Gly Ser Ile His Gln His Trp Gly Asn Asp Trp 
                325                 330                 335     


Asp Leu Gln Asn Arg Tyr Lys Leu Leu Gln Ser Ala Thr Glu Ala Gln 
            340                 345                 350         


Arg Gln Lys Ile Gln Arg Thr Ala Arg Lys Leu Phe Gly Leu Ser Val 
        355                 360                 365             


Arg Cys Arg His Asn Pro Asn His Gln Leu Pro Arg Glu Arg Thr Ile 
    370                 375                 380                 


Gln Gln Trp Leu Ala Arg Val Gln Ser Leu Leu Tyr Cys Asn Glu Asn 
385                 390                 395                 400 


Gly Phe Trp Gly Thr Phe Leu Glu Ser Gln Arg Ser Cys Val Cys His 
                405                 410                 415     


Gly Ser Thr Thr Leu Cys Gln Arg Pro Ile Pro Cys Val Ile Gly Gly 
            420                 425                 430         


Asn Asn Ser Cys Ala Met Cys Ser Leu Ala Asn Ile Ser Leu Cys Gly 
        435                 440                 445             


Ser Cys Asn Lys Gly Tyr Lys Leu Tyr Arg Gly Arg Cys Glu Pro Gln 
    450                 455                 460                 


Asn Val Asp Ser Glu Arg Ser Glu Gln Phe Ile Ser Phe Glu Thr Asp 
465                 470                 475                 480 


Leu Asp Phe Gln Asp Leu Glu Leu Lys Tyr Leu Leu Gln Lys Met Asp 
                485                 490                 495     


Ser Arg Leu Tyr Val His Thr Thr Phe Ile Ser Asn Glu Ile Arg Leu 
            500                 505                 510         


Asp Thr Phe Phe Asp Pro Arg Trp Arg Lys Arg Met Ser Leu Thr Leu 
        515                 520                 525             


Lys Ser Asn Lys Asn Arg Met Asp Phe Ile His Met Val Ile Gly Met 
    530                 535                 540                 


Ser Met Arg Ile Cys Gln Met Arg Asn Ser Ser Leu Asp Pro Met Phe 
545                 550                 555                 560 


Phe Val Tyr Val Asn Pro Phe Ser Gly Ser His Ser Glu Gly Trp Asn 
                565                 570                 575     


Met Pro Phe Gly Glu Phe Gly Tyr Pro Arg Trp Glu Lys Ile Arg Leu 
            580                 585                 590         


Gln Asn Ser Gln Cys Tyr Asn Trp Thr Leu Leu Leu Gly Asn Arg Trp 
        595                 600                 605             


Lys Thr Phe Phe Glu Thr Val His Ile Tyr Leu Arg Ser Arg Thr Arg 
    610                 615                 620                 


Leu Pro Thr Leu Leu Arg Asn Glu Thr Gly Gln Gly Pro Val Asp Leu 
625                 630                 635                 640 


Ser Asp Pro Ser Lys Arg Gln Phe Tyr Ile Lys Ile Ser Asp Val Gln 
                645                 650                 655     


Val Phe Gly Tyr Ser Leu Arg Phe Asn Ala Asp Leu Leu Arg Ser Ala 
            660                 665                 670         


Val Gln Gln Val Asn Gln Ser Tyr Thr Gln Gly Gly Gln Phe Tyr Ser 
        675                 680                 685             


Ser Ser Ser Val Met Leu Leu Leu Leu Asp Ile Arg Asp Arg Ile Asn 
    690                 695                 700                 


Arg Leu Ala Pro Pro Val Ala Pro Gly Lys Pro Gln Leu Asp Leu Phe 
705                 710                 715                 720 


Ser Cys Met Leu Lys His Arg Leu Lys Leu Thr Asn Ser Glu Ile Ile 
                725                 730                 735     


Arg Val Asn His Ala Leu Asp Leu Tyr Asn Thr Glu Ile Leu Lys Gln 
            740                 745                 750         


Ser Asp Gln Met Thr Ala Lys Leu Cys 
        755                 760     


<210>  1575
<211>  320
<212>  PRT
<213>  Homo Sapiens

<400>  1575

Met Asn Trp Arg Phe Val Glu Leu Leu Tyr Phe Leu Phe Ile Trp Gly 
1               5                   10                  15      


Arg Ile Ser Val Gln Pro Ser His Gln Glu Pro Ala Gly Thr Asp Gln 
            20                  25                  30          


His Val Ser Lys Glu Phe Asp Trp Leu Ile Ser Asp Arg Gly Pro Phe 
        35                  40                  45              


His His Ser Arg Ser Tyr Leu Ser Phe Val Glu Arg His Arg Gln Gly 
    50                  55                  60                  


Phe Thr Thr Arg Tyr Lys Ile Tyr Arg Glu Phe Ala Arg Trp Lys Val 
65                  70                  75                  80  


Arg Asn Thr Ala Ile Glu Arg Arg Asp Leu Val Arg His Pro Val Pro 
                85                  90                  95      


Leu Met Pro Glu Phe Gln Arg Ser Ile Arg Leu Leu Gly Arg Arg Pro 
            100                 105                 110         


Thr Thr Gln Gln Phe Ile Asp Thr Ile Ile Lys Lys Tyr Gly Thr His 
        115                 120                 125             


Leu Leu Ile Ser Ala Thr Leu Gly Gly Glu Glu Ala Leu Thr Met Tyr 
    130                 135                 140                 


Met Asp Lys Ser Arg Leu Asp Arg Lys Ser Gly Asn Ala Thr Gln Ser 
145                 150                 155                 160 


Val Glu Ala Leu His Gln Leu Ala Ser Ser Tyr Phe Val Asp Arg Asp 
                165                 170                 175     


Gly Thr Met Arg Arg Leu His Glu Ile Gln Ile Ser Thr Gly Ala Ile 
            180                 185                 190         


Lys Val Thr Glu Thr Arg Thr Gly Pro Leu Gly Cys Asn Ser Tyr Asp 
        195                 200                 205             


Asn Leu Asp Ser Val Ser Ser Val Leu Leu Gln Ser Thr Glu Ser Lys 
    210                 215                 220                 


Leu His Leu Gln Gly Leu Gln Ile Ile Phe Pro Gln Tyr Leu Gln Glu 
225                 230                 235                 240 


Lys Phe Val Gln Ser Ala Leu Ser Tyr Ile Met Cys Asn Gly Glu Gly 
                245                 250                 255     


Glu Tyr Leu Cys Gln Asn Ser Gln Cys Arg Cys Gln Cys Ala Glu Glu 
            260                 265                 270         


Phe Pro Gln Cys Asn Cys Pro Ile Thr Asp Ile Gln Ile Met Glu Tyr 
        275                 280                 285             


Thr Leu Ala Asn Met Ala Lys Ser Trp Ala Glu Ala Tyr Lys Asp Leu 
    290                 295                 300                 


Glu Asn Ser Gly Arg Glu Ser His Ser Val Pro Leu His Glu Trp Pro 
305                 310                 315                 320 


<210>  1576
<211>  783
<212>  PRT
<213>  Homo Sapiens

<400>  1576

Met Arg Trp Gln Cys Gly Thr Arg Phe Arg Gly Leu Arg Pro Ala Val 
1               5                   10                  15      


Ala Pro Trp Thr Ala Leu Leu Ala Leu Gly Leu Pro Gly Trp Val Leu 
            20                  25                  30          


Ala Val Ser Ala Thr Ala Ala Ala Val Val Pro Glu Gln His Ala Ser 
        35                  40                  45              


Val Ala Gly Gln His Pro Leu Asp Trp Leu Leu Thr Asp Arg Gly Pro 
    50                  55                  60                  


Phe His Arg Ala Gln Glu Tyr Ala Asp Phe Met Glu Arg Tyr Arg Gln 
65                  70                  75                  80  


Gly Phe Thr Thr Arg Tyr Arg Ile Tyr Arg Glu Phe Ala Arg Trp Lys 
                85                  90                  95      


Val Asn Asn Leu Ala Leu Glu Arg Lys Asp Phe Phe Ser Leu Pro Leu 
            100                 105                 110         


Pro Leu Ala Pro Glu Phe Ile Arg Asn Ile Arg Leu Leu Gly Arg Arg 
        115                 120                 125             


Pro Asn Leu Gln Gln Val Thr Glu Asn Leu Ile Lys Lys Tyr Gly Thr 
    130                 135                 140                 


His Phe Leu Leu Ser Ala Thr Leu Gly Gly Glu Glu Ser Leu Thr Ile 
145                 150                 155                 160 


Phe Val Asp Lys Gln Lys Leu Gly Arg Lys Thr Glu Thr Thr Gly Gly 
                165                 170                 175     


Ala Ser Ile Ile Gly Gly Ser Gly Asn Ser Thr Ala Val Ser Leu Glu 
            180                 185                 190         


Thr Leu His Gln Leu Ala Ala Ser Tyr Phe Ile Asp Arg Glu Ser Thr 
        195                 200                 205             


Leu Arg Arg Leu His His Ile Gln Ile Ala Thr Gly Ala Ile Lys Val 
    210                 215                 220                 


Thr Glu Thr Arg Thr Gly Pro Leu Gly Cys Ser Asn Tyr Asp Asn Leu 
225                 230                 235                 240 


Asp Ser Val Ser Ser Val Leu Val Gln Ser Pro Glu Asn Lys Val Gln 
                245                 250                 255     


Leu Leu Gly Leu Gln Val Leu Leu Pro Glu Tyr Leu Arg Glu Arg Phe 
            260                 265                 270         


Val Ala Ala Ala Leu Ser Tyr Ile Thr Cys Ser Ser Glu Gly Glu Leu 
        275                 280                 285             


Val Cys Lys Glu Asn Asp Cys Trp Cys Lys Cys Ser Pro Thr Phe Pro 
    290                 295                 300                 


Glu Cys Asn Cys Pro Asp Ala Asp Ile Gln Ala Met Glu Asp Ser Leu 
305                 310                 315                 320 


Leu Gln Ile Gln Asp Ser Trp Ala Thr His Asn Arg Gln Phe Glu Glu 
                325                 330                 335     


Ser Glu Glu Phe Gln Ala Leu Leu Lys Arg Leu Pro Asp Asp Arg Phe 
            340                 345                 350         


Leu Asn Ser Thr Ala Ile Ser Gln Phe Trp Ala Met Asp Thr Ser Leu 
        355                 360                 365             


Gln His Arg Tyr Gln Gln Leu Gly Ala Gly Leu Lys Val Leu Phe Lys 
    370                 375                 380                 


Lys Thr His Arg Ile Leu Arg Arg Leu Phe Asn Leu Cys Lys Arg Cys 
385                 390                 395                 400 


His Arg Gln Pro Arg Phe Arg Leu Pro Lys Glu Arg Ser Leu Ser Tyr 
                405                 410                 415     


Trp Trp Asn Arg Ile Gln Ser Leu Leu Tyr Cys Gly Glu Ser Thr Phe 
            420                 425                 430         


Pro Gly Thr Phe Leu Glu Gln Ser His Ser Cys Thr Cys Pro Tyr Asp 
        435                 440                 445             


Gln Ser Ser Cys Gln Gly Pro Ile Pro Cys Ala Leu Gly Glu Gly Pro 
    450                 455                 460                 


Ala Cys Ala His Cys Ala Pro Asp Asn Ser Thr Arg Cys Gly Ser Cys 
465                 470                 475                 480 


Asn Pro Gly Tyr Val Leu Ala Gln Gly Leu Cys Arg Pro Glu Val Ala 
                485                 490                 495     


Glu Ser Leu Glu Asn Phe Leu Gly Leu Glu Thr Asp Leu Gln Asp Leu 
            500                 505                 510         


Glu Leu Lys Tyr Leu Leu Gln Lys Gln Asp Ser Arg Ile Glu Val His 
        515                 520                 525             


Ser Ile Phe Ile Ser Asn Asp Met Arg Leu Gly Ser Trp Phe Asp Pro 
    530                 535                 540                 


Ser Trp Arg Lys Arg Met Leu Leu Thr Leu Lys Ser Asn Lys Tyr Lys 
545                 550                 555                 560 


Pro Gly Leu Val His Val Met Leu Ala Leu Ser Leu Gln Ile Cys Leu 
                565                 570                 575     


Thr Lys Asn Ser Thr Leu Glu Pro Val Met Ala Ile Tyr Val Asn Pro 
            580                 585                 590         


Phe Gly Gly Ser His Ser Glu Ser Trp Phe Met Pro Val Asn Glu Gly 
        595                 600                 605             


Ser Phe Pro Asp Trp Glu Arg Thr Asn Val Asp Ala Ala Ala Gln Cys 
    610                 615                 620                 


Gln Asn Trp Thr Ile Thr Leu Gly Asn Arg Trp Lys Thr Phe Phe Glu 
625                 630                 635                 640 


Thr Val His Val Tyr Leu Arg Ser Arg Ile Lys Ser Leu Asp Asp Ser 
                645                 650                 655     


Ser Asn Glu Thr Ile Tyr Tyr Glu Pro Leu Glu Met Thr Asp Pro Ser 
            660                 665                 670         


Lys Asn Leu Gly Tyr Met Lys Ile Asn Thr Leu Gln Val Phe Gly Tyr 
        675                 680                 685             


Ser Leu Pro Phe Asp Pro Asp Ala Ile Arg Asp Leu Ile Leu Gln Leu 
    690                 695                 700                 


Asp Tyr Pro Tyr Thr Gln Gly Ser Gln Asp Ser Ala Leu Leu Gln Leu 
705                 710                 715                 720 


Ile Glu Leu Arg Asp Arg Val Asn Gln Leu Ser Pro Pro Gly Lys Val 
                725                 730                 735     


Arg Leu Asp Leu Phe Ser Cys Leu Leu Arg His Arg Leu Lys Leu Ala 
            740                 745                 750         


Asn Asn Glu Val Gly Arg Ile Gln Ser Ser Leu Arg Ala Phe Asn Ser 
        755                 760                 765             


Lys Leu Pro Asn Pro Val Glu Tyr Glu Thr Gly Lys Leu Cys Ser 
    770                 775                 780             


<210>  1577
<211>  28
<212>  PRT
<213>  Homo Sapiens

<400>  1577

Met Ile Trp Arg Ser Arg Ala Gly Ala Glu Leu Phe Ser Leu Met Ala 
1               5                   10                  15      


Leu Trp Glu Trp Ile Ala Leu Ser Leu His Cys Trp 
            20                  25              


<210>  1578
<211>  158
<212>  PRT
<213>  Homo Sapiens

<400>  1578

Met Ile Trp Arg Ser Arg Ala Gly Ala Glu Leu Phe Ser Leu Met Ala 
1               5                   10                  15      


Leu Trp Glu Trp Ile Ala Leu Ser Leu His Cys Trp Val Leu Ala Val 
            20                  25                  30          


Ala Ala Val Ser Asp Gln His Ala Thr Ser Pro Phe Asp Trp Leu Leu 
        35                  40                  45              


Ser Asp Lys Gly Pro Phe His Arg Ser Gln Glu Tyr Thr Asp Phe Val 
    50                  55                  60                  


Asp Arg Ser Arg Gln Gly Phe Ser Thr Arg Tyr Lys Ile Tyr Arg Glu 
65                  70                  75                  80  


Phe Gly Arg Trp Lys Val Asn Asn Leu Ala Val Glu Arg Arg Asn Phe 
                85                  90                  95      


Leu Gly Ser Pro Leu Pro Leu Ala Pro Glu Phe Phe Arg Asn Ile Arg 
            100                 105                 110         


Leu Leu Gly Arg Arg Pro Thr Leu Gln Gln Ile Thr Glu Asn Leu Ile 
        115                 120                 125             


Lys Lys Tyr Gly Thr His Phe Leu Leu Ser Ala Thr Leu Gly Gly Glu 
    130                 135                 140                 


Glu Ser Leu Thr Ile Phe Val Asp Lys Arg Lys Leu Ser Lys 
145                 150                 155             


<210>  1579
<211>  766
<212>  PRT
<213>  Homo Sapiens

<400>  1579

Met Ile Trp Arg Ser Arg Ala Gly Ala Glu Leu Phe Ser Leu Met Ala 
1               5                   10                  15      


Leu Trp Glu Trp Ile Ala Leu Ser Leu His Cys Trp Val Leu Ala Val 
            20                  25                  30          


Ala Ala Val Ser Asp Gln His Ala Thr Ser Pro Phe Asp Trp Leu Leu 
        35                  40                  45              


Ser Asp Lys Gly Pro Phe His Arg Ser Gln Glu Tyr Thr Asp Phe Val 
    50                  55                  60                  


Asp Arg Ser Arg Gln Gly Phe Ser Thr Arg Tyr Lys Ile Tyr Arg Glu 
65                  70                  75                  80  


Phe Gly Arg Trp Lys Val Asn Asn Leu Ala Val Glu Arg Arg Asn Phe 
                85                  90                  95      


Leu Gly Ser Pro Leu Pro Leu Ala Pro Glu Phe Phe Arg Asn Ile Arg 
            100                 105                 110         


Leu Leu Gly Arg Arg Pro Thr Leu Gln Gln Ile Thr Glu Asn Leu Ile 
        115                 120                 125             


Lys Lys Tyr Gly Thr His Phe Leu Leu Ser Ala Thr Leu Gly Gly Glu 
    130                 135                 140                 


Glu Ser Leu Thr Ile Phe Val Asp Lys Arg Lys Leu Ser Lys Arg Ala 
145                 150                 155                 160 


Glu Gly Ser Asp Ser Thr Thr Asn Ser Ser Ser Val Thr Leu Glu Thr 
                165                 170                 175     


Leu His Gln Leu Ala Ala Ser Tyr Phe Ile Asp Arg Asp Ser Thr Leu 
            180                 185                 190         


Arg Arg Leu His His Ile Gln Ile Ala Ser Thr Ala Ile Lys Val Thr 
        195                 200                 205             


Glu Thr Arg Thr Gly Pro Leu Gly Cys Ser Asn Tyr Asp Asn Leu Asp 
    210                 215                 220                 


Ser Val Ser Ser Val Leu Val Gln Ser Pro Glu Asn Lys Ile Gln Leu 
225                 230                 235                 240 


Gln Gly Leu Gln Val Leu Leu Pro Asp Tyr Leu Gln Glu Arg Phe Val 
                245                 250                 255     


Gln Ala Ala Leu Ser Tyr Ile Ala Cys Asn Ser Glu Gly Glu Phe Ile 
            260                 265                 270         


Cys Lys Glu Asn Asp Cys Trp Cys His Cys Gly Pro Lys Phe Pro Glu 
        275                 280                 285             


Cys Asn Cys Pro Ser Met Asp Ile Gln Ala Met Glu Glu Asn Leu Leu 
    290                 295                 300                 


Arg Ile Thr Glu Thr Trp Lys Ala Tyr Asn Ser Asp Phe Glu Glu Ser 
305                 310                 315                 320 


Asp Glu Phe Lys Leu Phe Met Lys Arg Leu Pro Met Asn Tyr Phe Leu 
                325                 330                 335     


Asn Thr Ser Thr Ile Met His Leu Trp Thr Met Asp Ser Asn Phe Gln 
            340                 345                 350         


Arg Arg Tyr Glu Gln Leu Glu Asn Ser Met Lys Gln Leu Phe Leu Lys 
        355                 360                 365             


Ala Gln Lys Ile Val His Lys Leu Phe Ser Leu Ser Lys Arg Cys His 
    370                 375                 380                 


Lys Gln Pro Leu Ile Ser Leu Pro Arg Gln Arg Thr Ser Thr Tyr Trp 
385                 390                 395                 400 


Leu Thr Arg Ile Gln Ser Phe Leu Tyr Cys Asn Glu Asn Gly Leu Leu 
                405                 410                 415     


Gly Ser Phe Ser Glu Glu Thr His Ser Cys Thr Cys Pro Asn Asp Gln 
            420                 425                 430         


Val Val Cys Thr Ala Phe Leu Pro Cys Thr Val Gly Asp Ala Ser Ala 
        435                 440                 445             


Cys Leu Thr Cys Ala Pro Asp Asn Arg Thr Arg Cys Gly Thr Cys Asn 
    450                 455                 460                 


Thr Gly Tyr Met Leu Ser Gln Gly Leu Cys Lys Pro Glu Val Ala Glu 
465                 470                 475                 480 


Ser Thr Asp His Tyr Ile Gly Phe Glu Thr Asp Leu Gln Asp Leu Glu 
                485                 490                 495     


Met Lys Tyr Leu Leu Gln Lys Thr Asp Arg Arg Ile Glu Val His Ala 
            500                 505                 510         


Ile Phe Ile Ser Asn Asp Met Arg Leu Asn Ser Trp Phe Asp Pro Ser 
        515                 520                 525             


Trp Arg Lys Arg Met Leu Leu Thr Leu Lys Ser Asn Lys Tyr Lys Ser 
    530                 535                 540                 


Ser Leu Val His Met Ile Leu Gly Leu Ser Leu Gln Ile Cys Leu Thr 
545                 550                 555                 560 


Lys Asn Ser Thr Leu Glu Pro Val Leu Ala Val Tyr Val Asn Pro Phe 
                565                 570                 575     


Gly Gly Ser His Ser Glu Ser Trp Phe Met Pro Val Asn Glu Asn Ser 
            580                 585                 590         


Phe Pro Asp Trp Glu Arg Thr Lys Leu Asp Leu Pro Leu Gln Cys Tyr 
        595                 600                 605             


Asn Trp Thr Leu Thr Leu Gly Asn Lys Trp Lys Thr Phe Phe Glu Thr 
    610                 615                 620                 


Val His Ile Tyr Leu Arg Ser Arg Ile Lys Ser Asn Gly Pro Asn Gly 
625                 630                 635                 640 


Asn Glu Ser Ile Tyr Tyr Glu Pro Leu Glu Phe Ile Asp Pro Ser Arg 
                645                 650                 655     


Asn Leu Gly Tyr Met Lys Ile Asn Asn Ile Gln Val Phe Gly Tyr Ser 
            660                 665                 670         


Met His Phe Asp Pro Glu Ala Ile Arg Asp Leu Ile Leu Gln Leu Asp 
        675                 680                 685             


Tyr Pro Tyr Thr Gln Gly Ser Gln Asp Ser Ala Leu Leu Gln Leu Leu 
    690                 695                 700                 


Glu Ile Arg Asp Arg Val Asn Lys Leu Ser Pro Pro Gly Gln Arg Arg 
705                 710                 715                 720 


Leu Asp Leu Phe Ser Cys Leu Leu Arg His Arg Leu Lys Leu Ser Thr 
                725                 730                 735     


Ser Glu Val Val Arg Ile Gln Ser Ala Leu Gln Ala Phe Asn Ala Lys 
            740                 745                 750         


Leu Pro Asn Thr Met Asp Tyr Asp Thr Thr Lys Leu Cys Ser 
        755                 760                 765     


<210>  1580
<211>  385
<212>  PRT
<213>  Homo Sapiens

<400>  1580

Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Thr 
1               5                   10                  15      


His Gly Ala Ser Gly Ala Ala Gly Phe Val Gln Ala Pro Leu Ser Gln 
            20                  25                  30          


Gln Arg Trp Val Gly Gly Ser Val Glu Leu His Cys Glu Ala Val Gly 
        35                  40                  45              


Ser Pro Val Pro Glu Ile Gln Trp Trp Phe Glu Gly Gln Gly Pro Asn 
    50                  55                  60                  


Asp Thr Cys Ser Gln Leu Trp Asp Gly Ala Arg Leu Asp Arg Val His 
65                  70                  75                  80  


Ile His Ala Thr Tyr His Gln His Ala Ala Ser Thr Ile Ser Ile Asp 
                85                  90                  95      


Thr Leu Val Glu Glu Asp Thr Gly Thr Tyr Glu Cys Arg Ala Ser Asn 
            100                 105                 110         


Asp Pro Asp Arg Asn His Leu Thr Arg Ala Pro Arg Val Lys Trp Val 
        115                 120                 125             


Arg Ala Gln Ala Val Val Leu Val Leu Glu Pro Gly Thr Val Phe Thr 
    130                 135                 140                 


Thr Val Glu Asp Leu Gly Ser Lys Ile Leu Leu Thr Cys Ser Leu Asn 
145                 150                 155                 160 


Asp Ser Ala Thr Glu Val Thr Gly His Arg Trp Leu Lys Gly Gly Val 
                165                 170                 175     


Val Leu Lys Glu Asp Ala Leu Pro Gly Gln Lys Thr Glu Phe Lys Val 
            180                 185                 190         


Asp Ser Asp Asp Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu 
        195                 200                 205             


Pro Met Gly Thr Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys 
    210                 215                 220                 


Ala Val Lys Ser Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu 
225                 230                 235                 240 


Val Cys Lys Ser Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr 
                245                 250                 255     


Lys Ile Thr Asp Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser 
            260                 265                 270         


Arg Phe Phe Val Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu 
        275                 280                 285             


Asn Leu Asn Met Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr 
    290                 295                 300                 


Ser Ser Lys Gly Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser 
305                 310                 315                 320 


His Leu Ala Ala Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu 
                325                 330                 335     


Val Leu Val Thr Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu 
            340                 345                 350         


Asp Val Leu Asp Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser 
        355                 360                 365             


Gly Gln His Gln Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser 
    370                 375                 380                 


Ser 
385 


<210>  1581
<211>  55
<212>  PRT
<213>  Homo Sapiens

<400>  1581

Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Thr 
1               5                   10                  15      


His Gly Ala Ser Gly Ala Ala Gly Thr Val Phe Thr Thr Val Glu Asp 
            20                  25                  30          


Leu Gly Ser Lys Ile Leu Leu Thr Cys Ser Leu Asn Asp Ser Ala Thr 
        35                  40                  45              


Glu Gln Arg Ala Ala Pro Glu 
    50                  55  


<210>  1582
<211>  132
<212>  PRT
<213>  Homo Sapiens

<400>  1582

Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Thr 
1               5                   10                  15      


His Gly Ala Ser Gly Ala Ala Gly Thr Val Phe Thr Thr Val Glu Asp 
            20                  25                  30          


Leu Gly Ser Lys Ile Leu Leu Thr Cys Ser Leu Asn Asp Ser Ala Thr 
        35                  40                  45              


Glu Val Thr Gly His Arg Trp Leu Lys Gly Gly Val Val Leu Lys Glu 
    50                  55                  60                  


Asp Ala Leu Pro Gly Gln Lys Thr Glu Phe Lys Ala Pro Thr Arg Pro 
65                  70                  75                  80  


Ser Ser Arg Ser Ala Cys Ala Ala Thr Trp Pro Pro Ser Gly Pro Ser 
                85                  90                  95      


Trp Ala Ser Trp Leu Arg Cys Trp Cys Trp Ser Pro Ser Ser Ser Ser 
            100                 105                 110         


Thr Arg Ser Ala Gly Ser Pro Arg Thr Ser Trp Met Met Thr Thr Pro 
        115                 120                 125             


Ala Leu His Pro 
    130         


<210>  1583
<211>  269
<212>  PRT
<213>  Homo Sapiens

<400>  1583

Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Thr 
1               5                   10                  15      


His Gly Ala Ser Gly Ala Ala Gly Thr Val Phe Thr Thr Val Glu Asp 
            20                  25                  30          


Leu Gly Ser Lys Ile Leu Leu Thr Cys Ser Leu Asn Asp Ser Ala Thr 
        35                  40                  45              


Glu Val Thr Gly His Arg Trp Leu Lys Gly Gly Val Val Leu Lys Glu 
    50                  55                  60                  


Asp Ala Leu Pro Gly Gln Lys Thr Glu Phe Lys Val Asp Ser Asp Asp 
65                  70                  75                  80  


Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu Pro Met Gly Thr 
                85                  90                  95      


Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala Val Lys Ser 
            100                 105                 110         


Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu Val Cys Lys Ser 
        115                 120                 125             


Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr Lys Ile Thr Asp 
    130                 135                 140                 


Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg Phe Phe Val 
145                 150                 155                 160 


Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn Leu Asn Met 
                165                 170                 175     


Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr Ser Ser Lys Gly 
            180                 185                 190         


Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser His Leu Ala Ala 
        195                 200                 205             


Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu Val Leu Val Thr 
    210                 215                 220                 


Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu Asp Val Leu Asp 
225                 230                 235                 240 


Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser Gly Gln His Gln 
                245                 250                 255     


Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser Ser 
            260                 265                 


<210>  1584
<211>  161
<212>  PRT
<213>  Homo Sapiens

<400>  1584

Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Thr 
1               5                   10                  15      


His Gly Ala Ser Gly Ala Glu Asp Leu Gly Ser Lys Ile Leu Leu Thr 
            20                  25                  30          


Cys Ser Leu Asn Asp Ser Ala Thr Glu Val Thr Gly His Arg Trp Leu 
        35                  40                  45              


Lys Gly Gly Val Val Leu Lys Glu Asp Ala Leu Pro Gly Gln Lys Thr 
    50                  55                  60                  


Glu Phe Lys Val Asp Ser Asp Asp Gln Trp Gly Glu Tyr Ser Cys Val 
65                  70                  75                  80  


Phe Leu Pro Glu Pro Met Gly Thr Ala Asn Ile Gln Leu His Gly Pro 
                85                  90                  95      


Pro Arg Val Lys Ala Val Lys Ser Ser Glu His Ile Asn Glu Gly Glu 
            100                 105                 110         


Thr Ala Met Leu Val Cys Lys Ser Glu Ser Val Pro Pro Val Thr Asp 
        115                 120                 125             


Trp Ala Trp Tyr Lys Ile Thr Asp Ser Glu Asp Lys Ala Leu Met Asn 
    130                 135                 140                 


Gly Ser Glu Ser Arg Phe Phe Val Ser Ser Ser Gln Gly Arg Ser Glu 
145                 150                 155                 160 


Leu 
    


<210>  1585
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  1585

Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Thr 
1               5                   10                  15      


His Gly Ala Ser Gly Ala Gly Pro Pro Arg Val Lys Ala Val Lys Ser 
            20                  25                  30          


Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu Val Cys Lys Ser 
        35                  40                  45              


Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr Lys Ile Thr Asp 
    50                  55                  60                  


Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg Phe Phe Val 
65                  70                  75                  80  


Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn Leu Asn Met 
                85                  90                  95      


Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr Ser Ser Lys Gly 
            100                 105                 110         


Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser His Leu Ala Ala 
        115                 120                 125             


Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu Val Leu Val Thr 
    130                 135                 140                 


Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu Asp Val Leu Asp 
145                 150                 155                 160 


Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser Gly Gln His Gln 
                165                 170                 175     


Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser Ser 
            180                 185                 


<210>  1586
<211>  221
<212>  PRT
<213>  Homo Sapiens

<400>  1586

Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Thr 
1               5                   10                  15      


His Gly Ala Ser Gly Ala Val Phe Thr Thr Val Glu Asp Leu Gly Ser 
            20                  25                  30          


Lys Ile Leu Leu Thr Cys Ser Leu Asn Asp Ser Ala Thr Glu Val Thr 
        35                  40                  45              


Gly His Arg Trp Leu Lys Gly Gly Val Val Leu Lys Glu Asp Ala Leu 
    50                  55                  60                  


Pro Gly Gln Lys Thr Glu Phe Lys Val Asp Ser Asp Asp Gln Trp Gly 
65                  70                  75                  80  


Glu Tyr Ser Cys Val Phe Leu Pro Glu Pro Met Gly Thr Ala Asn Ile 
                85                  90                  95      


Gln Leu His Gly Pro Pro Arg Val Lys Ala Val Lys Ser Ser Glu His 
            100                 105                 110         


Ile Asn Glu Gly Glu Thr Ala Met Leu Val Cys Lys Ser Glu Ser Val 
        115                 120                 125             


Pro Pro Val Thr Asp Trp Ala Trp Tyr Lys Ile Thr Asp Ser Glu Asp 
    130                 135                 140                 


Lys Ala Leu Met Asn Gly Ser Glu Ser Arg Phe Phe Val Ser Ser Ser 
145                 150                 155                 160 


Gln Gly Arg Ser Glu Leu His Ile Glu Asn Leu Asn Met Glu Ala Asp 
                165                 170                 175     


Pro Gly Gln Tyr Arg Cys Asn Gly Thr Ser Ser Lys Gly Ser Asp Gln 
            180                 185                 190         


Ala Ile Ile Thr Leu Arg Val Arg Ser His Leu Ala Ala Leu Trp Pro 
        195                 200                 205             


Phe Leu Gly Ile Val Ala Glu Val Leu Val Leu Val Thr 
    210                 215                 220     


<210>  1587
<211>  52
<212>  PRT
<213>  Homo Sapiens

<400>  1587

Met Gly Thr Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala 
1               5                   10                  15      


Val Lys Ser Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu Val 
            20                  25                  30          


Cys Lys Ser Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr Lys 
        35                  40                  45              


Ile Thr Asp Ser 
    50          


<210>  1588
<211>  84
<212>  PRT
<213>  Homo Sapiens

<400>  1588

Met Gly Thr Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala 
1               5                   10                  15      


Val Lys Ser Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu Val 
            20                  25                  30          


Cys Lys Ser Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr Lys 
        35                  40                  45              


Ile Thr Asp Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg 
    50                  55                  60                  


Phe Phe Val Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn 
65                  70                  75                  80  


Leu Asn Met Glu 
                


<210>  1589
<211>  176
<212>  PRT
<213>  Homo Sapiens

<400>  1589

Met Gly Thr Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala 
1               5                   10                  15      


Val Lys Ser Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu Val 
            20                  25                  30          


Cys Lys Ser Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr Lys 
        35                  40                  45              


Ile Thr Asp Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg 
    50                  55                  60                  


Phe Phe Val Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn 
65                  70                  75                  80  


Leu Asn Met Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr Ser 
                85                  90                  95      


Ser Lys Gly Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser His 
            100                 105                 110         


Leu Ala Ala Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu Val 
        115                 120                 125             


Leu Val Thr Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu Asp 
    130                 135                 140                 


Val Leu Asp Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser Gly 
145                 150                 155                 160 


Gln His Gln Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser Ser 
                165                 170                 175     


<210>  1590
<211>  205
<212>  PRT
<213>  Homo Sapiens

<400>  1590

Met Lys Gln Ser Asp Ala Ser Pro Gln Glu Arg Val Asp Ser Asp Asp 
1               5                   10                  15      


Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu Pro Met Gly Thr 
            20                  25                  30          


Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala Val Lys Ser 
        35                  40                  45              


Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu Val Cys Lys Ser 
    50                  55                  60                  


Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr Lys Ile Thr Asp 
65                  70                  75                  80  


Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg Phe Phe Val 
                85                  90                  95      


Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn Leu Asn Met 
            100                 105                 110         


Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr Ser Ser Lys Gly 
        115                 120                 125             


Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser His Leu Ala Ala 
    130                 135                 140                 


Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu Val Leu Val Thr 
145                 150                 155                 160 


Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu Asp Val Leu Asp 
                165                 170                 175     


Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser Gly Gln His Gln 
            180                 185                 190         


Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser Ser 
        195                 200                 205 


<210>  1591
<211>  132
<212>  PRT
<213>  Homo Sapiens

<400>  1591

Met Gly Ser Leu Met Leu Leu Phe Val Glu Thr Thr Arg Asn Ser Ser 
1               5                   10                  15      


Ala Cys Ile Phe Pro Val Ile Leu Asn Glu Leu Ser Ser Thr Val Glu 
            20                  25                  30          


Thr Ile Thr His Phe Pro Glu Val Thr Asp Gly Glu Cys Val Phe Pro 
        35                  40                  45              


Phe His Tyr Lys Asn Gly Thr Tyr Tyr Asp Cys Ile Lys Ser Lys Ala 
    50                  55                  60                  


Arg His Lys Trp Cys Ser Leu Asn Lys Thr Tyr Glu Gly Tyr Trp Lys 
65                  70                  75                  80  


Phe Cys Ser Ala Glu Asp Phe Ala Asn Cys Val Phe Pro Phe Trp Tyr 
                85                  90                  95      


Arg Arg Leu Ile Tyr Trp Glu Cys Thr Asp Asp Gly Glu Ala Phe Gly 
            100                 105                 110         


Lys Lys Trp Cys Ser Leu Thr Lys Asn Phe Asn Lys Asp Arg Ile Trp 
        115                 120                 125             


Lys Tyr Cys Glu 
    130         


<210>  1592
<211>  155
<212>  PRT
<213>  Homo Sapiens

<400>  1592

Gly Leu Asp Tyr Gln Ser Cys Pro Thr Ser Glu Asp Cys Glu Asn Asn 
1               5                   10                  15      


Pro Val Asp Ser Phe Trp Lys Arg Ala Ser Ile Gln Tyr Ser Lys Asp 
            20                  25                  30          


Ser Ser Gly Val Ile His Val Met Leu Asn Gly Ser Glu Pro Thr Gly 
        35                  40                  45              


Ala Tyr Pro Ile Lys Gly Phe Phe Ala Asp Tyr Glu Ile Pro Asn Leu 
    50                  55                  60                  


Gln Lys Glu Lys Ile Thr Arg Ile Glu Ile Trp Val Met His Glu Ile 
65                  70                  75                  80  


Gly Gly Pro Asn Val Glu Ser Cys Gly Glu Gly Ser Met Lys Val Leu 
                85                  90                  95      


Glu Lys Arg Leu Lys Asp Met Gly Phe Gln Tyr Ser Cys Ile Asn Asp 
            100                 105                 110         


Tyr Arg Pro Val Lys Leu Leu Gln Cys Val Asp His Ser Thr His Pro 
        115                 120                 125             


Asp Cys Ala Leu Lys Ser Pro Lys Arg Leu Cys Gly Thr Leu Gly Val 
    130                 135                 140                 


Arg Pro Arg Ala Glu Pro Tyr Asn Arg Arg Phe 
145                 150                 155 


<210>  1593
<211>  318
<212>  PRT
<213>  Homo Sapiens

<400>  1593

Met Ala Ala Gln Gly Cys Ala Ala Ser Arg Leu Leu Gln Leu Leu Leu 
1               5                   10                  15      


Gln Leu Leu Leu Leu Leu Leu Leu Leu Ala Ala Gly Gly Ala Arg Ala 
            20                  25                  30          


Arg Trp Arg Gly Glu Gly Thr Ser Ala His Leu Arg Asp Ile Phe Leu 
        35                  40                  45              


Gly Arg Cys Ala Glu Tyr Arg Ala Leu Leu Ser Pro Glu Gln Arg Asn 
    50                  55                  60                  


Lys Asn Cys Thr Ala Ile Trp Glu Ala Phe Lys Val Ala Leu Asp Lys 
65                  70                  75                  80  


Asp Pro Cys Ser Val Leu Pro Ser Asp Tyr Asp Leu Phe Ile Asn Leu 
                85                  90                  95      


Ser Arg His Ser Ile Pro Arg Asp Lys Ser Leu Phe Trp Glu Asn Ser 
            100                 105                 110         


His Leu Leu Val Asn Ser Phe Ala Asp Asn Thr Arg Arg Phe Met Pro 
        115                 120                 125             


Leu Ser Asp Val Leu Tyr Gly Arg Val Ala Asp Phe Leu Ser Trp Cys 
    130                 135                 140                 


Arg Gln Lys Asn Asp Ser Gly Leu Asp Tyr Gln Ser Cys Pro Thr Ser 
145                 150                 155                 160 


Glu Asp Cys Glu Asn Asn Pro Val Asp Ser Phe Trp Lys Arg Ala Ser 
                165                 170                 175     


Ile Gln Tyr Ser Lys Asp Ser Ser Gly Val Ile His Val Met Leu Asn 
            180                 185                 190         


Gly Ser Glu Pro Thr Gly Ala Tyr Pro Ile Lys Gly Phe Phe Ala Asp 
        195                 200                 205             


Tyr Glu Ile Pro Asn Leu Gln Lys Glu Lys Ile Thr Arg Ile Glu Ile 
    210                 215                 220                 


Trp Val Met His Glu Ile Gly Gly Pro Asn Val Glu Ser Cys Gly Glu 
225                 230                 235                 240 


Gly Ser Met Lys Val Leu Glu Lys Arg Leu Lys Asp Met Gly Phe Gln 
                245                 250                 255     


Tyr Ser Cys Ile Asn Asp Tyr Arg Pro Val Lys Leu Leu Gln Cys Val 
            260                 265                 270         


Asp His Ser Thr His Pro Asp Cys Ala Leu Lys Ser Ala Ala Ala Ala 
        275                 280                 285             


Thr Gln Arg Lys Ala Pro Ser Leu Tyr Thr Glu Gln Arg Ala Gly Leu 
    290                 295                 300                 


Ile Ile Pro Leu Phe Leu Val Leu Ala Ser Arg Thr Gln Leu 
305                 310                 315             


<210>  1594
<211>  333
<212>  PRT
<213>  Homo Sapiens

<400>  1594

Met Ala Ala Gln Gly Cys Ala Ala Ser Arg Leu Leu Gln Leu Leu Leu 
1               5                   10                  15      


Gln Leu Leu Leu Leu Leu Leu Leu Leu Ala Ala Gly Gly Ala Arg Ala 
            20                  25                  30          


Arg Trp Arg Gly Glu Gly Thr Ser Ala His Leu Arg Asp Ile Phe Leu 
        35                  40                  45              


Gly Arg Cys Ala Glu Tyr Arg Ala Leu Leu Ser Pro Glu Gln Arg Gln 
    50                  55                  60                  


Ile Arg Asn Ser Arg Glu Pro Pro Val Leu His Thr Thr Gln Asn Lys 
65                  70                  75                  80  


Asn Cys Thr Ala Ile Trp Glu Ala Phe Lys Val Ala Leu Asp Lys Asp 
                85                  90                  95      


Pro Cys Ser Val Leu Pro Ser Asp Tyr Asp Leu Phe Ile Asn Leu Ser 
            100                 105                 110         


Arg His Ser Ile Pro Arg Asp Lys Ser Leu Phe Trp Glu Asn Ser His 
        115                 120                 125             


Leu Leu Val Asn Ser Phe Ala Asp Asn Thr Arg Arg Phe Met Pro Leu 
    130                 135                 140                 


Ser Asp Val Leu Tyr Gly Arg Val Ala Asp Phe Leu Ser Trp Cys Arg 
145                 150                 155                 160 


Gln Lys Asn Asp Ser Gly Leu Asp Tyr Gln Ser Cys Pro Thr Ser Glu 
                165                 170                 175     


Asp Cys Glu Asn Asn Pro Val Asp Ser Phe Trp Lys Arg Ala Ser Ile 
            180                 185                 190         


Gln Tyr Ser Lys Asp Ser Ser Gly Val Ile His Val Met Leu Asn Gly 
        195                 200                 205             


Ser Glu Pro Thr Gly Ala Tyr Pro Ile Lys Gly Phe Phe Ala Asp Tyr 
    210                 215                 220                 


Glu Ile Pro Asn Leu Gln Lys Glu Lys Ile Thr Arg Ile Glu Ile Trp 
225                 230                 235                 240 


Val Met His Glu Ile Gly Gly Pro Asn Val Glu Ser Cys Gly Glu Gly 
                245                 250                 255     


Ser Met Lys Val Leu Glu Lys Arg Leu Lys Asp Met Gly Phe Gln Tyr 
            260                 265                 270         


Ser Cys Ile Asn Asp Tyr Arg Pro Val Lys Leu Leu Gln Cys Val Asp 
        275                 280                 285             


His Ser Thr His Pro Asp Cys Ala Leu Lys Ser Ala Ala Ala Ala Thr 
    290                 295                 300                 


Gln Arg Lys Ala Pro Ser Leu Tyr Thr Glu Gln Arg Ala Gly Leu Ile 
305                 310                 315                 320 


Ile Pro Leu Phe Leu Val Leu Ala Ser Arg Thr Gln Leu 
                325                 330             


<210>  1595
<211>  97
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1595

Xaa Ser Glu Pro Thr Gly Ala Tyr Pro Ile Lys Gly Phe Phe Ala Asp 
1               5                   10                  15      


Tyr Glu Ile Pro Asn Leu Gln Lys Glu Lys Ile Thr Arg Ile Glu Ile 
            20                  25                  30          


Trp Val Met His Glu Ile Gly Gly Pro Asn Val Glu Ser Cys Gly Glu 
        35                  40                  45              


Gly Ser Met Lys Val Leu Glu Lys Arg Leu Lys Asp Met Gly Phe Gln 
    50                  55                  60                  


Tyr Ser Cys Ile Asn Asp Tyr Arg Pro Val Lys Leu Leu Gln Cys Val 
65                  70                  75                  80  


Asp His Ser Thr His Pro Asp Cys Ala Leu Lys Ser Lys Leu Trp Glu 
                85                  90                  95      


Pro 
    


<210>  1596
<211>  186
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1596

Xaa Ser Leu Phe Trp Glu Asn Ser His Leu Leu Val Asn Ser Phe Ala 
1               5                   10                  15      


Asp Asn Thr Arg Arg Phe Met Pro Leu Ser Asp Val Leu Tyr Gly Arg 
            20                  25                  30          


Val Ala Asp Phe Leu Ser Trp Cys Arg Gln Lys Asn Asp Ser Gly Leu 
        35                  40                  45              


Asp Tyr Gln Ser Cys Pro Thr Ser Glu Asp Cys Glu Asn Asn Pro Val 
    50                  55                  60                  


Asp Ser Phe Trp Lys Arg Ala Ser Ile Gln Tyr Ser Lys Asp Ser Ser 
65                  70                  75                  80  


Gly Val Ile His Val Met Leu Asn Gly Ser Glu Pro Thr Gly Ala Tyr 
                85                  90                  95      


Pro Ile Lys Gly Phe Phe Ala Asp Tyr Glu Ile Pro Asn Leu Gln Lys 
            100                 105                 110         


Glu Lys Ile Thr Arg Ile Glu Ile Trp Val Met His Glu Ile Gly Gly 
        115                 120                 125             


Pro Asn Val Glu Ser Cys Gly Glu Gly Ser Met Lys Val Leu Glu Lys 
    130                 135                 140                 


Arg Leu Lys Asp Met Gly Phe Gln Tyr Ser Cys Ile Asn Asp Tyr Arg 
145                 150                 155                 160 


Pro Val Lys Leu Leu Gln Cys Val Asp His Ser Thr His Pro Asp Cys 
                165                 170                 175     


Ala Leu Lys Ser Asp Gly Val Ser Pro Cys 
            180                 185     


<210>  1597
<211>  478
<212>  PRT
<213>  Homo Sapiens

<400>  1597

Met Pro Arg Arg Gly Tyr Ser Lys Pro Gly Ser Trp Gly Ser Phe Trp 
1               5                   10                  15      


Ala Met Leu Thr Leu Val Gly Leu Val Thr His Ala Ala Gln Arg Ala 
            20                  25                  30          


Asp Val Gly Gly Glu Ala Ala Gly Thr Ser Ile Asn His Ser Gln Ala 
        35                  40                  45              


Val Leu Gln Arg Leu Gln Glu Leu Leu Arg Gln Gly Asn Ala Ser Asp 
    50                  55                  60                  


Val Val Leu Arg Val Gln Ala Ala Gly Thr Asp Glu Val Arg Val Phe 
65                  70                  75                  80  


His Ala His Arg Leu Leu Leu Gly Leu His Ser Glu Leu Phe Leu Glu 
                85                  90                  95      


Leu Leu Ser Asn Gln Ser Glu Ala Val Leu Gln Glu Pro Gln Asp Cys 
            100                 105                 110         


Ala Ala Val Phe Asp Lys Phe Ile Arg Tyr Leu Tyr Cys Gly Glu Leu 
        115                 120                 125             


Thr Val Leu Leu Thr Gln Ala Ile Pro Leu His Arg Leu Ala Thr Lys 
    130                 135                 140                 


Tyr Gly Val Ser Ser Leu Gln Arg Gly Val Ala Asp Tyr Met Arg Ala 
145                 150                 155                 160 


His Leu Ala Gly Gly Ala Gly Pro Ala Val Gly Trp Tyr His Tyr Ala 
                165                 170                 175     


Val Gly Thr Gly Asp Glu Ala Leu Arg Glu Ser Cys Leu Gln Phe Leu 
            180                 185                 190         


Ala Trp Asn Leu Ser Ala Val Ala Ala Ser Thr Glu Trp Gly Ala Val 
        195                 200                 205             


Ser Pro Glu Leu Leu Trp Gln Leu Leu Gln Arg Ser Asp Leu Val Leu 
    210                 215                 220                 


Gln Asp Glu Leu Glu Leu Phe His Ala Leu Glu Ala Trp Leu Gly Arg 
225                 230                 235                 240 


Ala Arg Pro Pro Pro Ala Val Ala Glu Arg Ala Leu Arg Ala Ile Arg 
                245                 250                 255     


Tyr Pro Met Ile Pro Pro Ala Gln Leu Phe Gln Leu Gln Ala Arg Ser 
            260                 265                 270         


Ala Ala Leu Ala Arg His Gly Pro Ala Val Ala Asp Leu Leu Leu Gln 
        275                 280                 285             


Ala Tyr Gln Phe His Ala Ala Ser Pro Leu His Tyr Ala Lys Phe Phe 
    290                 295                 300                 


Asp Val Asn Gly Ser Ala Phe Leu Pro Arg Asn Tyr Leu Ala Pro Ala 
305                 310                 315                 320 


Trp Gly Ala Pro Trp Val Ile Asn Asn Pro Ala Arg Asp Asp Arg Ser 
                325                 330                 335     


Thr Ser Phe Gln Thr Gln Leu Gly Pro Ser Gly His Asp Ala Gly Arg 
            340                 345                 350         


Arg Val Thr Trp Asn Val Leu Phe Ser Pro Arg Trp Leu Pro Val Ser 
        355                 360                 365             


Leu Arg Pro Val Tyr Ala Asp Ala Ala Gly Thr Ala Leu Pro Ala Ala 
    370                 375                 380                 


Arg Pro Glu Asp Gly Arg Pro Arg Leu Val Val Thr Pro Ala Ser Ser 
385                 390                 395                 400 


Gly Gly Asp Ala Ala Gly Val Ser Phe Gln Lys Thr Val Leu Val Gly 
                405                 410                 415     


Ala Arg Gln Gln Gly Arg Leu Leu Val Arg His Ala Tyr Ser Phe His 
            420                 425                 430         


Gln Ser Ser Glu Glu Ala Gly Asp Phe Leu Ala His Ala Asp Leu Gln 
        435                 440                 445             


Arg Arg Asn Ser Glu Tyr Leu Val Glu Asn Ala Leu His Leu His Leu 
    450                 455                 460                 


Ile Val Lys Pro Val Tyr His Thr Leu Ile Arg Thr Pro Lys 
465                 470                 475             


<210>  1598
<211>  179
<212>  PRT
<213>  Homo Sapiens

<400>  1598

Met Ala His Ala His Ile Gln Gly Gly Arg Arg Ala Lys Ser Arg Phe 
1               5                   10                  15      


Val Val Cys Ile Met Ser Gly Ala Arg Ser Lys Leu Ala Leu Phe Leu 
            20                  25                  30          


Cys Gly Cys Tyr Val Val Ala Leu Gly Ala His Thr Gly Glu Glu Ser 
        35                  40                  45              


Val Ala Asp His His Glu Ala Glu Tyr Tyr Val Ala Ala Val Tyr Glu 
    50                  55                  60                  


His Pro Ser Ile Leu Ser Leu Asn Pro Leu Ala Leu Ile Ser Arg Gln 
65                  70                  75                  80  


Glu Ala Leu Glu Leu Met Asn Gln Asn Leu Asp Ile Tyr Glu Gln Gln 
                85                  90                  95      


Val Met Thr Ala Ala Gln Lys Asp Val Gln Ile Ile Val Phe Pro Glu 
            100                 105                 110         


Asp Gly Ile His Gly Phe Asn Phe Thr Arg Thr Ser Ile Tyr Pro Phe 
        115                 120                 125             


Leu Asp Phe Met Pro Ser Pro Gln Val Val Arg Trp Asn Pro Cys Leu 
    130                 135                 140                 


Glu Pro His Arg Phe Asn Asp Thr Glu Val Ile Pro Ala Phe Phe Leu 
145                 150                 155                 160 


Ser Arg Leu Arg Val His Arg Gly Asp Leu Ser Gln Gly Pro Glu Ala 
                165                 170                 175     


Val Thr Cys 
            


<210>  1599
<211>  543
<212>  PRT
<213>  Homo Sapiens

<400>  1599

Met Ala His Ala His Ile Gln Gly Gly Arg Arg Ala Lys Ser Arg Phe 
1               5                   10                  15      


Val Val Cys Ile Met Ser Gly Ala Arg Ser Lys Leu Ala Leu Phe Leu 
            20                  25                  30          


Cys Gly Cys Tyr Val Val Ala Leu Gly Ala His Thr Gly Glu Glu Ser 
        35                  40                  45              


Val Ala Asp His His Glu Ala Glu Tyr Tyr Val Ala Ala Val Tyr Glu 
    50                  55                  60                  


His Pro Ser Ile Leu Ser Leu Asn Pro Leu Ala Leu Ile Ser Arg Gln 
65                  70                  75                  80  


Glu Ala Leu Glu Leu Met Asn Gln Asn Leu Asp Ile Tyr Glu Gln Gln 
                85                  90                  95      


Val Met Thr Ala Ala Gln Lys Asp Val Gln Ile Ile Val Phe Pro Glu 
            100                 105                 110         


Asp Gly Ile His Gly Phe Asn Phe Thr Arg Thr Ser Ile Tyr Pro Phe 
        115                 120                 125             


Leu Asp Phe Met Pro Ser Pro Gln Val Val Arg Trp Asn Pro Cys Leu 
    130                 135                 140                 


Glu Pro His Arg Phe Asn Asp Thr Glu Val Leu Gln Arg Leu Ser Cys 
145                 150                 155                 160 


Met Ala Ile Arg Gly Asp Met Phe Leu Val Ala Asn Leu Gly Thr Lys 
                165                 170                 175     


Glu Pro Cys His Ser Ser Asp Pro Arg Cys Pro Lys Asp Gly Arg Tyr 
            180                 185                 190         


Gln Phe Asn Thr Asn Val Val Phe Ser Asn Asn Gly Thr Leu Val Asp 
        195                 200                 205             


Arg Tyr Arg Lys His Asn Leu Tyr Phe Glu Ala Ala Phe Asp Val Pro 
    210                 215                 220                 


Leu Lys Val Asp Leu Ile Thr Phe Asp Thr Pro Phe Ala Gly Arg Phe 
225                 230                 235                 240 


Gly Ile Phe Thr Cys Phe Asp Ile Leu Phe Phe Asp Pro Ala Ile Arg 
                245                 250                 255     


Val Leu Arg Asp Tyr Lys Val Lys His Val Val Tyr Pro Thr Ala Trp 
            260                 265                 270         


Met Asn Gln Leu Pro Leu Leu Ala Ala Ile Glu Ile Gln Lys Ala Phe 
        275                 280                 285             


Ala Val Ala Phe Gly Ile Asn Val Leu Ala Ala Asn Val His His Pro 
    290                 295                 300                 


Val Leu Gly Met Thr Gly Ser Gly Ile His Thr Pro Leu Glu Ser Phe 
305                 310                 315                 320 


Trp Tyr His Asp Met Glu Asn Pro Lys Ser His Leu Ile Ile Ala Gln 
                325                 330                 335     


Val Ala Lys Asn Pro Val Gly Leu Ile Gly Ala Glu Asn Ala Thr Gly 
            340                 345                 350         


Glu Thr Asp Pro Ser His Ser Lys Phe Leu Lys Ile Leu Ser Gly Asp 
        355                 360                 365             


Pro Tyr Cys Glu Lys Asp Ala Gln Glu Val His Cys Asp Glu Ala Thr 
    370                 375                 380                 


Lys Trp Asn Val Asn Ala Pro Pro Thr Phe His Ser Glu Met Met Tyr 
385                 390                 395                 400 


Asp Asn Phe Thr Leu Val Pro Val Trp Gly Lys Glu Gly Tyr Leu His 
                405                 410                 415     


Val Cys Ser Asn Gly Leu Cys Cys Tyr Leu Leu Tyr Glu Arg Pro Thr 
            420                 425                 430         


Leu Ser Lys Glu Leu Tyr Ala Leu Gly Val Phe Asp Gly Leu His Thr 
        435                 440                 445             


Val His Gly Thr Tyr Tyr Ile Gln Val Cys Ala Leu Val Arg Cys Gly 
    450                 455                 460                 


Gly Leu Gly Phe Asp Thr Cys Gly Gln Glu Ile Thr Glu Ala Thr Gly 
465                 470                 475                 480 


Ile Phe Glu Phe His Leu Trp Gly Asn Phe Ser Thr Ser Tyr Ile Phe 
                485                 490                 495     


Pro Leu Phe Leu Thr Ser Gly Met Thr Leu Glu Val Pro Asp Gln Leu 
            500                 505                 510         


Gly Trp Glu Asn Asp His Tyr Phe Leu Arg Lys Ser Arg Leu Ser Ser 
        515                 520                 525             


Gly Leu Val Thr Ala Ala Leu Tyr Gly Arg Leu Tyr Glu Arg Asp 
    530                 535                 540             


<210>  1600
<211>  545
<212>  PRT
<213>  Homo Sapiens

<400>  1600

Met Ala Arg Lys Glu Thr Gln Leu Ile Ile Lys Met Asn His Leu Ala 
1               5                   10                  15      


Arg Phe Val Val Cys Ile Met Ser Gly Ala Arg Ser Lys Leu Ala Leu 
            20                  25                  30          


Phe Leu Cys Gly Cys Tyr Val Val Ala Leu Gly Ala His Thr Gly Glu 
        35                  40                  45              


Glu Ser Val Ala Asp His His Glu Ala Glu Tyr Tyr Val Ala Ala Val 
    50                  55                  60                  


Tyr Glu His Pro Ser Ile Leu Ser Leu Asn Pro Leu Ala Leu Ile Ser 
65                  70                  75                  80  


Arg Gln Glu Ala Leu Glu Leu Met Asn Gln Asn Leu Asp Ile Tyr Glu 
                85                  90                  95      


Gln Gln Val Met Thr Ala Ala Gln Lys Asp Val Gln Ile Ile Val Phe 
            100                 105                 110         


Pro Glu Asp Gly Ile His Gly Phe Asn Phe Thr Arg Thr Ser Ile Tyr 
        115                 120                 125             


Pro Phe Leu Asp Phe Met Pro Ser Pro Gln Val Val Arg Trp Asn Pro 
    130                 135                 140                 


Cys Leu Glu Pro His Arg Phe Asn Asp Thr Glu Val Leu Gln Arg Leu 
145                 150                 155                 160 


Ser Cys Met Ala Ile Arg Gly Asp Met Phe Leu Val Ala Asn Leu Gly 
                165                 170                 175     


Thr Lys Glu Pro Cys His Ser Ser Asp Pro Arg Cys Pro Lys Asp Gly 
            180                 185                 190         


Arg Tyr Gln Phe Asn Thr Asn Val Val Phe Ser Asn Asn Gly Thr Leu 
        195                 200                 205             


Val Asp Arg Tyr Arg Lys His Asn Leu Tyr Phe Glu Ala Ala Phe Asp 
    210                 215                 220                 


Val Pro Leu Lys Val Asp Leu Ile Thr Phe Asp Thr Pro Phe Ala Gly 
225                 230                 235                 240 


Arg Phe Gly Ile Phe Thr Cys Phe Asp Ile Leu Phe Phe Asp Pro Ala 
                245                 250                 255     


Ile Arg Val Leu Arg Asp Tyr Lys Val Lys His Val Val Tyr Pro Thr 
            260                 265                 270         


Ala Trp Met Asn Gln Leu Pro Leu Leu Ala Ala Ile Glu Ile Gln Lys 
        275                 280                 285             


Ala Phe Ala Val Ala Phe Gly Ile Asn Val Leu Ala Ala Asn Val His 
    290                 295                 300                 


His Pro Val Leu Gly Met Thr Gly Ser Gly Ile His Thr Pro Leu Glu 
305                 310                 315                 320 


Ser Phe Trp Tyr His Asp Met Glu Asn Pro Lys Ser His Leu Ile Ile 
                325                 330                 335     


Ala Gln Val Ala Lys Asn Pro Val Gly Leu Ile Gly Ala Glu Asn Ala 
            340                 345                 350         


Thr Gly Glu Thr Asp Pro Ser His Ser Lys Phe Leu Lys Ile Leu Ser 
        355                 360                 365             


Gly Asp Pro Tyr Cys Glu Lys Asp Ala Gln Glu Val His Cys Asp Glu 
    370                 375                 380                 


Ala Thr Lys Trp Asn Val Asn Ala Pro Pro Thr Phe His Ser Glu Met 
385                 390                 395                 400 


Met Tyr Asp Asn Phe Thr Leu Val Pro Val Trp Gly Lys Glu Gly Tyr 
                405                 410                 415     


Leu His Val Cys Ser Asn Gly Leu Cys Cys Tyr Leu Leu Tyr Glu Arg 
            420                 425                 430         


Pro Thr Leu Ser Lys Glu Leu Tyr Ala Leu Gly Val Phe Asp Gly Leu 
        435                 440                 445             


His Thr Val His Gly Thr Tyr Tyr Ile Gln Val Cys Ala Leu Val Arg 
    450                 455                 460                 


Cys Gly Gly Leu Gly Phe Asp Thr Cys Gly Gln Glu Ile Thr Glu Ala 
465                 470                 475                 480 


Thr Gly Ile Phe Glu Phe His Leu Trp Gly Asn Phe Ser Thr Ser Tyr 
                485                 490                 495     


Ile Phe Pro Leu Phe Leu Thr Ser Gly Met Thr Leu Glu Val Pro Asp 
            500                 505                 510         


Gln Leu Gly Trp Glu Asn Asp His Tyr Phe Leu Arg Lys Ser Arg Leu 
        515                 520                 525             


Ser Ser Gly Leu Val Thr Ala Ala Leu Tyr Gly Arg Leu Tyr Glu Arg 
    530                 535                 540                 


Asp 
545 


<210>  1601
<211>  545
<212>  PRT
<213>  Homo Sapiens

<400>  1601

Met Pro Glu Gly Gly Gly Thr Ser Arg Arg Leu Leu Pro Met Gln Ser 
1               5                   10                  15      


Arg Phe Val Val Cys Ile Met Ser Gly Ala Arg Ser Lys Leu Ala Leu 
            20                  25                  30          


Phe Leu Cys Gly Cys Tyr Val Val Ala Leu Gly Ala His Thr Gly Glu 
        35                  40                  45              


Glu Ser Val Ala Asp His His Glu Ala Glu Tyr Tyr Val Ala Ala Val 
    50                  55                  60                  


Tyr Glu His Pro Ser Ile Leu Ser Leu Asn Pro Leu Ala Leu Ile Ser 
65                  70                  75                  80  


Arg Gln Glu Ala Leu Glu Leu Met Asn Gln Asn Leu Asp Ile Tyr Glu 
                85                  90                  95      


Gln Gln Val Met Thr Ala Ala Gln Lys Asp Val Gln Ile Ile Val Phe 
            100                 105                 110         


Pro Glu Asp Gly Ile His Gly Phe Asn Phe Thr Arg Thr Ser Ile Tyr 
        115                 120                 125             


Pro Phe Leu Asp Phe Met Pro Ser Pro Gln Val Val Arg Trp Asn Pro 
    130                 135                 140                 


Cys Leu Glu Pro His Arg Phe Asn Asp Thr Glu Val Leu Gln Arg Leu 
145                 150                 155                 160 


Ser Cys Met Ala Ile Arg Gly Asp Met Phe Leu Val Ala Asn Leu Gly 
                165                 170                 175     


Thr Lys Glu Pro Cys His Ser Ser Asp Pro Arg Cys Pro Lys Asp Gly 
            180                 185                 190         


Arg Tyr Gln Phe Asn Thr Asn Val Val Phe Ser Asn Asn Gly Thr Leu 
        195                 200                 205             


Val Asp Arg Tyr Arg Lys His Asn Leu Tyr Phe Glu Ala Ala Phe Asp 
    210                 215                 220                 


Val Pro Leu Lys Val Asp Leu Ile Thr Phe Asp Thr Pro Phe Ala Gly 
225                 230                 235                 240 


Arg Phe Gly Ile Phe Thr Cys Phe Asp Ile Leu Phe Phe Asp Pro Ala 
                245                 250                 255     


Ile Arg Val Leu Arg Asp Tyr Lys Val Lys His Val Val Tyr Pro Thr 
            260                 265                 270         


Ala Trp Met Asn Gln Leu Pro Leu Leu Ala Ala Ile Glu Ile Gln Lys 
        275                 280                 285             


Ala Phe Ala Val Ala Phe Gly Ile Asn Val Leu Ala Ala Asn Val His 
    290                 295                 300                 


His Pro Val Leu Gly Met Thr Gly Ser Gly Ile His Thr Pro Leu Glu 
305                 310                 315                 320 


Ser Phe Trp Tyr His Asp Met Glu Asn Pro Lys Ser His Leu Ile Ile 
                325                 330                 335     


Ala Gln Val Ala Lys Asn Pro Val Gly Leu Ile Gly Ala Glu Asn Ala 
            340                 345                 350         


Thr Gly Glu Thr Asp Pro Ser His Ser Lys Phe Leu Lys Ile Leu Ser 
        355                 360                 365             


Gly Asp Pro Tyr Cys Glu Lys Asp Ala Gln Glu Val His Cys Asp Glu 
    370                 375                 380                 


Ala Thr Lys Trp Asn Val Asn Ala Pro Pro Thr Phe His Ser Glu Met 
385                 390                 395                 400 


Met Tyr Asp Asn Phe Thr Leu Val Pro Val Trp Gly Lys Glu Gly Tyr 
                405                 410                 415     


Leu His Val Cys Ser Asn Gly Leu Cys Cys Tyr Leu Leu Tyr Glu Arg 
            420                 425                 430         


Pro Thr Leu Ser Lys Glu Leu Tyr Ala Leu Gly Val Phe Asp Gly Leu 
        435                 440                 445             


His Thr Val His Gly Thr Tyr Tyr Ile Gln Val Cys Ala Leu Val Arg 
    450                 455                 460                 


Cys Gly Gly Leu Gly Phe Asp Thr Cys Gly Gln Glu Ile Thr Glu Ala 
465                 470                 475                 480 


Thr Gly Ile Phe Glu Phe His Leu Trp Gly Asn Phe Ser Thr Ser Tyr 
                485                 490                 495     


Ile Phe Pro Leu Phe Leu Thr Ser Gly Met Thr Leu Glu Val Pro Asp 
            500                 505                 510         


Gln Leu Gly Trp Glu Asn Asp His Tyr Phe Leu Arg Lys Ser Arg Leu 
        515                 520                 525             


Ser Ser Gly Leu Val Thr Ala Ala Leu Tyr Gly Arg Leu Tyr Glu Arg 
    530                 535                 540                 


Asp 
545 


<210>  1602
<211>  159
<212>  PRT
<213>  Homo Sapiens

<400>  1602

Met Ser Gly Ala Arg Ser Lys Leu Ala Leu Phe Leu Cys Gly Cys Tyr 
1               5                   10                  15      


Val Val Ala Leu Gly Ala His Thr Gly Glu Glu Ser Val Ala Asp His 
            20                  25                  30          


His Glu Ala Glu Tyr Tyr Val Ala Ala Val Tyr Glu His Pro Ser Ile 
        35                  40                  45              


Leu Ser Leu Asn Pro Leu Ala Leu Ile Ser Arg Gln Glu Ala Leu Glu 
    50                  55                  60                  


Leu Met Asn Gln Asn Leu Asp Ile Tyr Glu Gln Gln Val Met Thr Ala 
65                  70                  75                  80  


Ala Gln Lys Asp Val Gln Ile Ile Val Phe Pro Glu Asp Gly Ile His 
                85                  90                  95      


Gly Phe Asn Phe Thr Arg Thr Ser Ile Tyr Pro Phe Leu Asp Phe Met 
            100                 105                 110         


Pro Ser Pro Gln Val Val Arg Trp Asn Pro Cys Leu Glu Pro His Arg 
        115                 120                 125             


Phe Asn Asp Thr Glu Val Ile Pro Ala Phe Phe Leu Ser Arg Leu Arg 
    130                 135                 140                 


Val His Arg Gly Asp Leu Ser Gln Gly Pro Glu Ala Val Thr Cys 
145                 150                 155                 


<210>  1603
<211>  251
<212>  PRT
<213>  Homo Sapiens

<400>  1603

Met Ser Gly Ala Arg Ser Lys Leu Ala Leu Phe Leu Cys Gly Cys Tyr 
1               5                   10                  15      


Val Val Ala Leu Gly Ala His Thr Gly Glu Glu Ser Val Ala Asp His 
            20                  25                  30          


His Glu Ala Glu Tyr Tyr Val Ala Ala Val Tyr Glu His Pro Ser Ile 
        35                  40                  45              


Leu Ser Leu Asn Pro Leu Ala Leu Ile Ser Arg Gln Glu Ala Leu Glu 
    50                  55                  60                  


Leu Met Asn Gln Asn Leu Asp Ile Tyr Glu Gln Gln Val Met Thr Ala 
65                  70                  75                  80  


Ala Gln Lys Asp Val Gln Ile Ile Val Phe Pro Glu Asp Gly Ile His 
                85                  90                  95      


Gly Phe Asn Phe Thr Arg Thr Ser Ile Tyr Pro Phe Leu Asp Phe Met 
            100                 105                 110         


Pro Ser Pro Gln Val Val Arg Trp Asn Pro Cys Leu Glu Pro His Arg 
        115                 120                 125             


Phe Asn Asp Thr Glu Val Leu Gln Arg Leu Ser Cys Met Ala Ile Arg 
    130                 135                 140                 


Gly Asp Met Phe Leu Val Ala Asn Leu Gly Thr Lys Glu Pro Cys His 
145                 150                 155                 160 


Ser Ser Asp Pro Arg Cys Pro Lys Asp Gly Arg Tyr Gln Phe Asn Thr 
                165                 170                 175     


Asn Val Val Phe Ser Asn Asn Gly Thr Leu Val Asp Arg Tyr Arg Lys 
            180                 185                 190         


His Asn Leu Tyr Phe Glu Ala Ala Phe Asp Val Pro Leu Lys Val Asp 
        195                 200                 205             


Leu Ile Thr Phe Asp Thr Pro Phe Ala Gly Arg Phe Gly Ile Phe Thr 
    210                 215                 220                 


Cys Phe Asp Ile Leu Phe Phe Asp Pro Ala Ile Arg Val Leu Arg Asp 
225                 230                 235                 240 


Tyr Lys Val Lys His Val Val Tyr Pro Thr Ala 
                245                 250     


<210>  1604
<211>  523
<212>  PRT
<213>  Homo Sapiens

<400>  1604

Met Ser Gly Ala Arg Ser Lys Leu Ala Leu Phe Leu Cys Gly Cys Tyr 
1               5                   10                  15      


Val Val Ala Leu Gly Ala His Thr Gly Glu Glu Ser Val Ala Asp His 
            20                  25                  30          


His Glu Ala Glu Tyr Tyr Val Ala Ala Val Tyr Glu His Pro Ser Ile 
        35                  40                  45              


Leu Ser Leu Asn Pro Leu Ala Leu Ile Ser Arg Gln Glu Ala Leu Glu 
    50                  55                  60                  


Leu Met Asn Gln Asn Leu Asp Ile Tyr Glu Gln Gln Val Met Thr Ala 
65                  70                  75                  80  


Ala Gln Lys Asp Val Gln Ile Ile Val Phe Pro Glu Asp Gly Ile His 
                85                  90                  95      


Gly Phe Asn Phe Thr Arg Thr Ser Ile Tyr Pro Phe Leu Asp Phe Met 
            100                 105                 110         


Pro Ser Pro Gln Val Val Arg Trp Asn Pro Cys Leu Glu Pro His Arg 
        115                 120                 125             


Phe Asn Asp Thr Glu Val Leu Gln Arg Leu Ser Cys Met Ala Ile Arg 
    130                 135                 140                 


Gly Asp Met Phe Leu Val Ala Asn Leu Gly Thr Lys Glu Pro Cys His 
145                 150                 155                 160 


Ser Ser Asp Pro Arg Cys Pro Lys Asp Gly Arg Tyr Gln Phe Asn Thr 
                165                 170                 175     


Asn Val Val Phe Ser Asn Asn Gly Thr Leu Val Asp Arg Tyr Arg Lys 
            180                 185                 190         


His Asn Leu Tyr Phe Glu Ala Ala Phe Asp Val Pro Leu Lys Val Asp 
        195                 200                 205             


Leu Ile Thr Phe Asp Thr Pro Phe Ala Gly Arg Phe Gly Ile Phe Thr 
    210                 215                 220                 


Cys Phe Asp Ile Leu Phe Phe Asp Pro Ala Ile Arg Val Leu Arg Asp 
225                 230                 235                 240 


Tyr Lys Val Lys His Val Val Tyr Pro Thr Ala Trp Met Asn Gln Leu 
                245                 250                 255     


Pro Leu Leu Ala Ala Ile Glu Ile Gln Lys Ala Phe Ala Val Ala Phe 
            260                 265                 270         


Gly Ile Asn Val Leu Ala Ala Asn Val His His Pro Val Leu Gly Met 
        275                 280                 285             


Thr Gly Ser Gly Ile His Thr Pro Leu Glu Ser Phe Trp Tyr His Asp 
    290                 295                 300                 


Met Glu Asn Pro Lys Ser His Leu Ile Ile Ala Gln Val Ala Lys Asn 
305                 310                 315                 320 


Pro Val Gly Leu Ile Gly Ala Glu Asn Ala Thr Gly Glu Thr Asp Pro 
                325                 330                 335     


Ser His Ser Lys Phe Leu Lys Ile Leu Ser Gly Asp Pro Tyr Cys Glu 
            340                 345                 350         


Lys Asp Ala Gln Glu Val His Cys Asp Glu Ala Thr Lys Trp Asn Val 
        355                 360                 365             


Asn Ala Pro Pro Thr Phe His Ser Glu Met Met Tyr Asp Asn Phe Thr 
    370                 375                 380                 


Leu Val Pro Val Trp Gly Lys Glu Gly Tyr Leu His Val Cys Ser Asn 
385                 390                 395                 400 


Gly Leu Cys Cys Tyr Leu Leu Tyr Glu Arg Pro Thr Leu Ser Lys Glu 
                405                 410                 415     


Leu Tyr Ala Leu Gly Val Phe Asp Gly Leu His Thr Val His Gly Thr 
            420                 425                 430         


Tyr Tyr Ile Gln Val Cys Ala Leu Val Arg Cys Gly Gly Leu Gly Phe 
        435                 440                 445             


Asp Thr Cys Gly Gln Glu Ile Thr Glu Ala Thr Gly Ile Phe Glu Phe 
    450                 455                 460                 


His Leu Trp Gly Asn Phe Ser Thr Ser Tyr Ile Phe Pro Leu Phe Leu 
465                 470                 475                 480 


Thr Ser Gly Met Thr Leu Glu Val Pro Asp Gln Leu Gly Trp Glu Asn 
                485                 490                 495     


Asp His Tyr Phe Leu Arg Lys Ser Arg Leu Ser Ser Gly Leu Val Thr 
            500                 505                 510         


Ala Ala Leu Tyr Gly Arg Leu Tyr Glu Arg Asp 
        515                 520             


<210>  1605
<211>  523
<212>  PRT
<213>  Homo Sapiens

<400>  1605

Met Ser Gly Ala Arg Ser Lys Leu Ala Leu Phe Leu Cys Gly Cys Tyr 
1               5                   10                  15      


Val Val Ala Leu Gly Ala His Thr Gly Glu Glu Ser Val Ala Asp His 
            20                  25                  30          


His Glu Ala Glu Tyr Tyr Val Ala Ala Val Tyr Glu His Pro Ser Ile 
        35                  40                  45              


Leu Ser Leu Asn Pro Leu Ala Leu Ile Ser Arg Gln Glu Ala Leu Glu 
    50                  55                  60                  


Leu Met Asn Gln Asn Leu Asp Ile Tyr Glu Gln Gln Val Met Thr Ala 
65                  70                  75                  80  


Ala Gln Lys Asp Val Gln Ile Ile Val Phe Pro Glu Asp Gly Ile His 
                85                  90                  95      


Gly Phe Asn Phe Thr Arg Thr Ser Ile Tyr Pro Phe Leu Asp Phe Met 
            100                 105                 110         


Pro Ser Pro Gln Val Val Arg Trp Asn Pro Cys Leu Glu Pro His Arg 
        115                 120                 125             


Phe Asn Asp Thr Glu Val Leu Gln Arg Leu Ser Cys Met Ala Ile Arg 
    130                 135                 140                 


Gly Asp Met Phe Leu Val Ala Asn Leu Gly Thr Lys Glu Pro Cys His 
145                 150                 155                 160 


Ser Ser Asp Pro Arg Cys Pro Lys Asp Gly Arg Tyr Gln Phe Asn Thr 
                165                 170                 175     


Asn Val Val Phe Ser Asn Asn Gly Thr Leu Val Asp Arg Tyr Arg Lys 
            180                 185                 190         


His Asn Leu Tyr Phe Glu Ala Ala Phe Asp Val Pro Leu Lys Val Asp 
        195                 200                 205             


Leu Ile Thr Phe Asp Thr Pro Phe Ala Gly Arg Phe Gly Ile Phe Thr 
    210                 215                 220                 


Cys Phe Asp Ile Leu Phe Phe Asp Pro Ala Ile Arg Val Leu Arg Asp 
225                 230                 235                 240 


Tyr Lys Val Lys His Val Val Tyr Pro Thr Ala Trp Met Asn Gln Leu 
                245                 250                 255     


Pro Leu Leu Ala Ala Ile Glu Ile Gln Lys Ala Phe Ala Val Ala Phe 
            260                 265                 270         


Gly Ile Asn Val Leu Ala Ala Asn Val His His Pro Val Leu Gly Met 
        275                 280                 285             


Thr Gly Ser Gly Ile His Thr Pro Leu Glu Ser Phe Trp Tyr His Asp 
    290                 295                 300                 


Met Glu Asn Pro Lys Ser His Leu Ile Ile Ala Gln Val Ala Lys Asn 
305                 310                 315                 320 


Pro Val Gly Leu Ile Gly Ala Glu Asn Ala Thr Gly Glu Thr Asp Pro 
                325                 330                 335     


Ser His Ser Lys Phe Leu Lys Ile Leu Ser Gly Asp Pro Tyr Cys Glu 
            340                 345                 350         


Lys Asp Ala Gln Glu Val His Cys Asp Glu Ala Thr Lys Trp Asn Val 
        355                 360                 365             


Asn Ala Pro Pro Thr Phe His Ser Glu Met Met Tyr Asp Asn Phe Thr 
    370                 375                 380                 


Leu Val Pro Val Trp Gly Lys Glu Gly Tyr Leu His Val Cys Ser Asn 
385                 390                 395                 400 


Gly Leu Cys Cys Tyr Leu Leu Tyr Glu Arg Pro Thr Leu Ser Lys Glu 
                405                 410                 415     


Leu Tyr Ala Leu Gly Val Phe Asp Gly Leu His Thr Val His Gly Thr 
            420                 425                 430         


Tyr Tyr Ile Gln Val Cys Ala Leu Val Arg Cys Gly Gly Leu Gly Phe 
        435                 440                 445             


Asp Thr Cys Gly Gln Glu Ile Thr Glu Ala Thr Gly Ile Phe Glu Phe 
    450                 455                 460                 


His Leu Trp Gly Asn Phe Ser Thr Ser Tyr Ile Phe Pro Leu Phe Leu 
465                 470                 475                 480 


Thr Ser Gly Met Thr Leu Glu Val Pro Asp Gln Leu Gly Trp Glu Asn 
                485                 490                 495     


Asp His Tyr Phe Leu Arg Lys Ser Arg Leu Ser Ser Gly Leu Val Thr 
            500                 505                 510         


Ala Ala Leu Tyr Gly Arg Leu Tyr Glu Arg Asp 
        515                 520             


<210>  1606
<211>  523
<212>  PRT
<213>  Homo Sapiens

<400>  1606

Met Ser Gly Ala Arg Ser Lys Leu Ala Leu Phe Leu Cys Gly Cys Tyr 
1               5                   10                  15      


Val Val Ala Leu Gly Ala His Thr Gly Glu Glu Ser Val Ala Asp His 
            20                  25                  30          


His Glu Ala Glu Tyr Tyr Val Ala Ala Val Tyr Glu His Pro Ser Ile 
        35                  40                  45              


Leu Ser Leu Asn Pro Leu Ala Leu Ile Ser Arg Gln Glu Ala Leu Glu 
    50                  55                  60                  


Leu Met Asn Gln Asn Leu Asp Ile Tyr Glu Gln Gln Val Met Thr Ala 
65                  70                  75                  80  


Ala Gln Lys Asp Val Gln Ile Ile Val Phe Pro Glu Asp Gly Ile His 
                85                  90                  95      


Gly Phe Asn Phe Thr Arg Thr Ser Ile Tyr Pro Phe Leu Asp Phe Met 
            100                 105                 110         


Pro Ser Pro Gln Val Val Arg Trp Asn Pro Cys Leu Glu Pro His Arg 
        115                 120                 125             


Phe Asn Asp Thr Glu Val Leu Gln Arg Leu Ser Cys Met Ala Ile Arg 
    130                 135                 140                 


Gly Asp Met Phe Leu Val Ala Asn Leu Gly Thr Lys Glu Pro Cys His 
145                 150                 155                 160 


Ser Ser Asp Pro Arg Cys Pro Lys Asp Gly Arg Tyr Gln Phe Asn Thr 
                165                 170                 175     


Asn Val Val Phe Ser Asn Asn Gly Thr Leu Val Asp Arg Tyr Arg Lys 
            180                 185                 190         


His Asn Leu Tyr Phe Glu Ala Ala Phe Asp Val Pro Leu Lys Val Asp 
        195                 200                 205             


Leu Ile Thr Phe Asp Thr Pro Phe Ala Gly Arg Phe Gly Ile Phe Thr 
    210                 215                 220                 


Cys Phe Asp Ile Leu Phe Phe Asp Pro Ala Ile Arg Val Leu Arg Asp 
225                 230                 235                 240 


Tyr Lys Val Lys His Val Val Tyr Pro Thr Ala Trp Met Asn Gln Leu 
                245                 250                 255     


Pro Leu Leu Ala Ala Ile Glu Ile Gln Lys Ala Phe Ala Val Ala Phe 
            260                 265                 270         


Gly Ile Asn Val Leu Ala Ala Asn Val His His Pro Val Leu Gly Met 
        275                 280                 285             


Thr Gly Ser Gly Ile His Thr Pro Leu Glu Ser Phe Trp Tyr His Asp 
    290                 295                 300                 


Met Glu Asn Pro Lys Ser His Leu Ile Ile Ala Gln Val Ala Lys Asn 
305                 310                 315                 320 


Pro Val Gly Leu Ile Gly Ala Glu Asn Ala Thr Gly Glu Thr Asp Pro 
                325                 330                 335     


Ser His Ser Lys Phe Leu Lys Ile Leu Ser Gly Asp Pro Tyr Cys Glu 
            340                 345                 350         


Lys Asp Ala Gln Glu Val His Cys Asp Glu Ala Thr Lys Trp Asn Val 
        355                 360                 365             


Asn Ala Pro Pro Thr Phe His Ser Glu Met Met Tyr Asp Asn Phe Thr 
    370                 375                 380                 


Leu Val Pro Val Trp Gly Lys Glu Gly Tyr Leu His Val Cys Ser Asn 
385                 390                 395                 400 


Gly Leu Cys Cys Tyr Leu Leu Tyr Glu Arg Pro Thr Leu Ser Lys Glu 
                405                 410                 415     


Leu Tyr Ala Leu Gly Val Phe Asp Gly Leu His Thr Val His Gly Thr 
            420                 425                 430         


Tyr Tyr Ile Gln Val Cys Ala Leu Val Arg Cys Gly Gly Leu Gly Phe 
        435                 440                 445             


Asp Thr Cys Gly Gln Glu Ile Thr Glu Ala Thr Gly Ile Phe Glu Phe 
    450                 455                 460                 


His Leu Trp Gly Asn Phe Ser Thr Ser Tyr Ile Phe Pro Leu Phe Leu 
465                 470                 475                 480 


Thr Ser Gly Met Thr Leu Glu Val Pro Asp Gln Leu Gly Trp Glu Asn 
                485                 490                 495     


Asp His Tyr Phe Leu Arg Lys Ser Arg Leu Ser Ser Gly Leu Val Thr 
            500                 505                 510         


Ala Ala Leu Tyr Gly Arg Leu Tyr Glu Arg Asp 
        515                 520             


<210>  1607
<211>  523
<212>  PRT
<213>  Homo Sapiens

<400>  1607

Met Ser Gly Ala Arg Ser Lys Leu Ala Leu Phe Leu Cys Gly Cys Tyr 
1               5                   10                  15      


Val Val Ala Leu Gly Ala His Thr Gly Glu Glu Ser Val Ala Asp His 
            20                  25                  30          


His Glu Ala Glu Tyr Tyr Val Ala Ala Val Tyr Glu His Pro Ser Ile 
        35                  40                  45              


Leu Ser Leu Asn Pro Leu Ala Leu Ile Ser Arg Gln Glu Ala Leu Glu 
    50                  55                  60                  


Leu Met Asn Gln Asn Leu Asp Ile Tyr Glu Gln Gln Val Met Thr Ala 
65                  70                  75                  80  


Ala Gln Lys Asp Val Gln Ile Ile Val Phe Pro Glu Asp Gly Ile His 
                85                  90                  95      


Gly Phe Asn Phe Thr Arg Thr Ser Ile Tyr Pro Phe Leu Asp Phe Met 
            100                 105                 110         


Pro Ser Pro Gln Val Val Arg Trp Asn Pro Cys Leu Glu Pro His Arg 
        115                 120                 125             


Phe Asn Asp Thr Glu Val Leu Gln Arg Leu Ser Cys Met Ala Ile Arg 
    130                 135                 140                 


Gly Asp Met Phe Leu Val Ala Asn Leu Gly Thr Lys Glu Pro Cys His 
145                 150                 155                 160 


Ser Ser Asp Pro Arg Cys Pro Lys Asp Gly Arg Tyr Gln Phe Asn Thr 
                165                 170                 175     


Asn Val Val Phe Ser Asn Asn Gly Thr Leu Val Asp Arg Tyr Arg Lys 
            180                 185                 190         


His Asn Leu Tyr Phe Glu Ala Ala Phe Asp Val Pro Leu Lys Val Asp 
        195                 200                 205             


Leu Ile Thr Phe Asp Thr Pro Phe Ala Gly Arg Phe Gly Ile Phe Thr 
    210                 215                 220                 


Cys Phe Asp Ile Leu Phe Phe Asp Pro Ala Ile Arg Val Leu Arg Asp 
225                 230                 235                 240 


Tyr Lys Val Lys His Val Val Tyr Pro Thr Ala Trp Met Asn Gln Leu 
                245                 250                 255     


Pro Leu Leu Ala Ala Ile Glu Ile Gln Lys Ala Phe Ala Val Ala Phe 
            260                 265                 270         


Gly Ile Asn Val Leu Ala Ala Asn Val His His Pro Val Leu Gly Met 
        275                 280                 285             


Thr Gly Ser Gly Ile His Thr Pro Leu Glu Ser Phe Trp Tyr His Asp 
    290                 295                 300                 


Met Glu Asn Pro Lys Ser His Leu Ile Ile Ala Gln Val Ala Lys Asn 
305                 310                 315                 320 


Pro Val Gly Leu Ile Gly Ala Glu Asn Ala Thr Gly Glu Thr Asp Pro 
                325                 330                 335     


Ser His Ser Lys Phe Leu Lys Ile Leu Ser Gly Asp Pro Tyr Cys Glu 
            340                 345                 350         


Lys Asp Ala Gln Glu Val His Cys Asp Glu Ala Thr Lys Trp Asn Val 
        355                 360                 365             


Asn Ala Pro Pro Thr Phe His Ser Glu Met Met Tyr Asp Asn Phe Thr 
    370                 375                 380                 


Leu Val Pro Val Trp Gly Lys Glu Gly Tyr Leu His Val Cys Ser Asn 
385                 390                 395                 400 


Gly Leu Cys Cys Tyr Leu Leu Tyr Glu Arg Pro Thr Leu Ser Lys Glu 
                405                 410                 415     


Leu Tyr Ala Leu Gly Val Phe Asp Gly Leu His Thr Val His Gly Thr 
            420                 425                 430         


Tyr Tyr Ile Gln Val Cys Ala Leu Val Arg Cys Gly Gly Leu Gly Phe 
        435                 440                 445             


Asp Thr Cys Gly Gln Glu Ile Thr Glu Ala Thr Gly Ile Phe Glu Phe 
    450                 455                 460                 


His Leu Trp Gly Asn Phe Ser Thr Ser Tyr Ile Phe Pro Leu Phe Leu 
465                 470                 475                 480 


Thr Ser Gly Met Thr Leu Glu Val Pro Asp Gln Leu Gly Trp Glu Asn 
                485                 490                 495     


Asp His Tyr Phe Leu Arg Lys Ser Arg Leu Ser Ser Gly Leu Val Thr 
            500                 505                 510         


Ala Ala Leu Tyr Gly Arg Leu Tyr Glu Arg Asp 
        515                 520             


<210>  1608
<211>  56
<212>  PRT
<213>  Homo Sapiens

<400>  1608

Phe Ile Ile Phe Met Ala Val Ser Ile Cys Cys Ile Lys Lys Leu Gln 
1               5                   10                  15      


Arg Glu Lys Lys Ile Leu Ser Gly Glu Lys Lys Val Glu Gln Glu Glu 
            20                  25                  30          


Lys Glu Ile Ala Gln Gln Leu Gln Glu Glu Leu Arg Trp Arg Arg Thr 
        35                  40                  45              


Phe Leu His Ala Gly Glu Cys Leu 
    50                  55      


<210>  1609
<211>  96
<212>  PRT
<213>  Homo Sapiens

<400>  1609

Met Glu Pro Ala Ala Ala Leu His Phe Ser Leu Pro Ala Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Ser Leu Cys Ala Leu Val Ser Ala 
            20                  25                  30          


Gln Phe Thr Val Val Gly Pro Ala Asn Pro Ile Leu Ala Met Val Gly 
        35                  40                  45              


Glu Asn Thr Thr Leu Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu 
    50                  55                  60                  


Asp Met Glu Val Arg Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe 
65                  70                  75                  80  


Val Tyr Lys Gly Gly Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr 
                85                  90                  95      


<210>  1610
<211>  256
<212>  PRT
<213>  Homo Sapiens

<400>  1610

Met Glu Pro Ala Ala Ala Leu His Phe Ser Leu Pro Ala Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Ser Leu Cys Ala Leu Val Ser Ala 
            20                  25                  30          


Gln Phe Thr Val Val Gly Pro Ala Asn Pro Ile Leu Ala Met Val Gly 
        35                  40                  45              


Glu Asn Thr Thr Leu Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu 
    50                  55                  60                  


Asp Met Glu Val Arg Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe 
65                  70                  75                  80  


Val Tyr Lys Gly Gly Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr 
                85                  90                  95      


Arg Gly Arg Ile Thr Phe Val Ser Lys Asp Ile Asn Arg Gly Ser Val 
            100                 105                 110         


Ala Leu Val Ile His Asn Val Thr Ala Gln Glu Asn Gly Ile Tyr Arg 
        115                 120                 125             


Cys Tyr Phe Gln Glu Gly Arg Ser Tyr Asp Glu Ala Ile Leu Arg Leu 
    130                 135                 140                 


Val Val Ala Glu Ser Phe Met Pro Ser Ala Ser Pro Trp Met Val Ala 
145                 150                 155                 160 


Leu Ala Val Ile Leu Thr Ala Ser Pro Trp Met Val Ser Met Thr Val 
                165                 170                 175     


Ile Leu Ala Val Phe Ile Ile Phe Met Ala Val Ser Ile Cys Cys Ile 
            180                 185                 190         


Lys Lys Leu Gln Arg Glu Lys Lys Ile Leu Ser Gly Glu Lys Lys Val 
        195                 200                 205             


Glu Gln Glu Glu Lys Glu Ile Ala Gln Gln Leu Gln Glu Glu Leu Arg 
    210                 215                 220                 


Trp Arg Arg Thr Phe Leu His Ala Gly Tyr Glu Leu Pro Gly Ile Arg 
225                 230                 235                 240 


Gly Pro Ser Trp Lys Arg Pro Leu His Gly Glu Pro Pro Ser Ala Phe 
                245                 250                 255     


<210>  1611
<211>  239
<212>  PRT
<213>  Homo Sapiens

<400>  1611

Met Glu Pro Ala Ala Ala Leu His Phe Ser Leu Pro Ala Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Ser Leu Cys Ala Leu Val Ser Ala 
            20                  25                  30          


Gln Phe Thr Val Val Gly Pro Ala Asn Pro Ile Leu Ala Met Val Gly 
        35                  40                  45              


Glu Asn Thr Thr Leu Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu 
    50                  55                  60                  


Asp Met Glu Val Arg Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe 
65                  70                  75                  80  


Val Tyr Lys Gly Gly Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr 
                85                  90                  95      


Arg Gly Arg Ile Thr Phe Val Ser Lys Asp Ile Asn Arg Gly Ser Val 
            100                 105                 110         


Ala Leu Val Ile His Asn Val Thr Ala Gln Glu Asn Gly Ile Tyr Arg 
        115                 120                 125             


Cys Tyr Phe Gln Glu Gly Arg Ser Tyr Asp Glu Ala Ile Leu Arg Leu 
    130                 135                 140                 


Val Val Ala Gly Leu Gly Ser Lys Pro Leu Ile Glu Ile Lys Ala Gln 
145                 150                 155                 160 


Glu Asp Gly Ser Ile Trp Leu Glu Cys Ile Ser Gly Gly Trp Tyr Pro 
                165                 170                 175     


Glu Pro Leu Thr Val Trp Arg Asp Pro Tyr Gly Glu Val Val Pro Ala 
            180                 185                 190         


Leu Lys Glu Val Ser Ile Ala Asp Ala Asp Gly Leu Phe Met Val Thr 
        195                 200                 205             


Thr Ala Val Ile Ile Arg Asp Lys Tyr Val Arg Asn Val Ser Cys Ser 
    210                 215                 220                 


Val Asn Asn Thr Leu Leu Gly Gln Glu Lys Glu Thr Val Ile Phe 
225                 230                 235                 


<210>  1612
<211>  523
<212>  PRT
<213>  Homo Sapiens

<400>  1612

Met Glu Pro Ala Ala Ala Leu His Phe Ser Leu Pro Ala Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Ser Leu Cys Ala Leu Val Ser Ala 
            20                  25                  30          


Gln Phe Thr Val Val Gly Pro Ala Asn Pro Ile Leu Ala Met Val Gly 
        35                  40                  45              


Glu Asn Thr Thr Leu Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu 
    50                  55                  60                  


Asp Met Glu Val Arg Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe 
65                  70                  75                  80  


Val Tyr Lys Gly Gly Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr 
                85                  90                  95      


Arg Gly Arg Ile Thr Phe Val Ser Lys Asp Ile Asn Arg Gly Ser Val 
            100                 105                 110         


Ala Leu Val Ile His Asn Val Thr Ala Gln Glu Asn Gly Ile Tyr Arg 
        115                 120                 125             


Cys Tyr Phe Gln Glu Gly Arg Ser Tyr Asp Glu Ala Ile Leu Arg Leu 
    130                 135                 140                 


Val Val Ala Gly Leu Gly Ser Lys Pro Leu Ile Glu Ile Lys Ala Gln 
145                 150                 155                 160 


Glu Asp Gly Ser Ile Trp Leu Glu Cys Ile Ser Gly Gly Trp Tyr Pro 
                165                 170                 175     


Glu Pro Leu Thr Val Trp Arg Asp Pro Tyr Gly Glu Val Val Pro Ala 
            180                 185                 190         


Leu Lys Glu Val Ser Ile Ala Asp Ala Asp Gly Leu Phe Met Val Thr 
        195                 200                 205             


Thr Ala Val Ile Ile Arg Asp Lys Tyr Val Arg Asn Val Ser Cys Ser 
    210                 215                 220                 


Val Asn Asn Thr Leu Leu Gly Gln Glu Lys Glu Thr Val Ile Phe Ile 
225                 230                 235                 240 


Pro Glu Ser Phe Met Pro Ser Ala Ser Pro Trp Met Val Ala Leu Ala 
                245                 250                 255     


Val Ile Leu Thr Ala Ser Pro Trp Met Val Ser Met Thr Val Ile Leu 
            260                 265                 270         


Ala Val Phe Ile Ile Phe Met Ala Val Ser Ile Cys Cys Ile Lys Lys 
        275                 280                 285             


Leu Gln Arg Glu Lys Lys Ile Leu Ser Gly Glu Lys Lys Val Glu Gln 
    290                 295                 300                 


Glu Glu Lys Glu Ile Ala Gln Gln Leu Gln Glu Glu Leu Arg Trp Arg 
305                 310                 315                 320 


Arg Thr Phe Leu His Ala Ala Asp Val Val Leu Asp Pro Asp Thr Ala 
                325                 330                 335     


His Pro Glu Leu Phe Leu Ser Glu Asp Arg Arg Ser Val Arg Arg Gly 
            340                 345                 350         


Pro Tyr Arg Gln Arg Val Pro Asp Asn Pro Glu Arg Phe Asp Ser Gln 
        355                 360                 365             


Pro Cys Val Leu Gly Trp Glu Ser Phe Ala Ser Gly Lys His Tyr Trp 
    370                 375                 380                 


Glu Val Glu Val Glu Asn Val Met Val Trp Thr Val Gly Val Cys Arg 
385                 390                 395                 400 


His Ser Val Glu Arg Lys Gly Glu Val Leu Leu Ile Pro Gln Asn Gly 
                405                 410                 415     


Phe Trp Thr Leu Glu Met Phe Gly Asn Gln Tyr Arg Ala Leu Ser Ser 
            420                 425                 430         


Pro Glu Arg Ile Leu Pro Leu Lys Glu Ser Leu Cys Arg Val Gly Val 
        435                 440                 445             


Phe Leu Asp Tyr Glu Ala Gly Asp Val Ser Phe Tyr Asn Met Arg Asp 
    450                 455                 460                 


Arg Ser His Ile Tyr Thr Cys Pro Arg Ser Ala Phe Thr Val Pro Val 
465                 470                 475                 480 


Arg Pro Phe Phe Arg Leu Gly Ser Asp Asp Ser Pro Ile Phe Ile Cys 
                485                 490                 495     


Pro Ala Leu Thr Gly Ala Ser Gly Val Met Val Pro Glu Glu Gly Leu 
            500                 505                 510         


Lys Leu His Arg Val Gly Thr His Gln Ser Leu 
        515                 520             


<210>  1613
<211>  336
<212>  PRT
<213>  Homo Sapiens

<400>  1613

Met Glu Pro Ala Ala Ala Leu His Phe Ser Leu Pro Ala Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Ser Leu Cys Ala Leu Val Ser Ala 
            20                  25                  30          


Gln Phe Thr Val Val Gly Pro Ala Asn Pro Ile Leu Ala Met Val Gly 
        35                  40                  45              


Glu Asn Thr Thr Leu Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu 
    50                  55                  60                  


Asp Met Glu Val Arg Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe 
65                  70                  75                  80  


Val Tyr Lys Gly Gly Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr 
                85                  90                  95      


Arg Gly Arg Ile Thr Phe Val Ser Lys Asp Ile Asn Arg Gly Ser Val 
            100                 105                 110         


Ala Leu Val Ile His Asn Val Thr Ala Gln Glu Asn Gly Ile Tyr Arg 
        115                 120                 125             


Cys Tyr Phe Gln Glu Gly Arg Ser Tyr Asp Glu Ala Ile Leu Arg Leu 
    130                 135                 140                 


Val Val Ala Gly Leu Gly Ser Lys Pro Leu Ile Glu Ile Lys Ala Gln 
145                 150                 155                 160 


Glu Asp Gly Ser Ile Trp Leu Glu Cys Ile Ser Gly Gly Trp Tyr Pro 
                165                 170                 175     


Glu Pro Leu Thr Val Trp Arg Asp Pro Tyr Gly Glu Val Val Pro Ala 
            180                 185                 190         


Leu Lys Glu Val Ser Ile Ala Asp Ala Asp Gly Leu Phe Met Val Thr 
        195                 200                 205             


Thr Ala Val Ile Ile Arg Asp Lys Tyr Val Arg Asn Val Ser Cys Ser 
    210                 215                 220                 


Val Asn Asn Thr Leu Leu Gly Gln Glu Lys Glu Thr Val Ile Phe Ile 
225                 230                 235                 240 


Pro Glu Ser Phe Met Pro Ser Ala Ser Pro Trp Met Val Ala Leu Ala 
                245                 250                 255     


Val Ile Leu Thr Ala Ser Pro Trp Met Val Ser Met Thr Val Ile Leu 
            260                 265                 270         


Ala Val Phe Ile Ile Phe Met Ala Val Ser Ile Cys Cys Ile Lys Lys 
        275                 280                 285             


Leu Gln Arg Glu Lys Lys Ile Leu Ser Gly Glu Lys Lys Val Glu Gln 
    290                 295                 300                 


Glu Glu Lys Glu Ile Ala Gln Gln Leu Gln Glu Glu Leu Arg Trp Arg 
305                 310                 315                 320 


Arg Thr Phe Leu His Ala Asp Val Asn Leu Thr Gly Leu Arg Asn Thr 
                325                 330                 335     


<210>  1614
<211>  523
<212>  PRT
<213>  Homo Sapiens

<400>  1614

Met Glu Pro Ala Ala Ala Leu His Phe Ser Leu Pro Ala Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Ser Leu Cys Ala Leu Val Ser Ala 
            20                  25                  30          


Gln Phe Thr Val Val Gly Pro Ala Asn Pro Ile Leu Ala Met Val Gly 
        35                  40                  45              


Glu Asn Thr Thr Leu Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu 
    50                  55                  60                  


Asp Met Glu Val Arg Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe 
65                  70                  75                  80  


Val Tyr Lys Gly Gly Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr 
                85                  90                  95      


Arg Gly Arg Ile Thr Phe Val Ser Lys Asp Ile Asn Arg Gly Ser Val 
            100                 105                 110         


Ala Leu Val Ile His Asn Val Thr Ala Gln Glu Asn Gly Ile Tyr Arg 
        115                 120                 125             


Cys Tyr Phe Gln Glu Gly Arg Ser Tyr Asp Glu Ala Ile Leu Arg Leu 
    130                 135                 140                 


Val Val Ala Gly Leu Gly Ser Lys Pro Leu Ile Glu Ile Lys Ala Gln 
145                 150                 155                 160 


Glu Asp Gly Ser Ile Trp Leu Glu Cys Ile Ser Gly Gly Trp Tyr Pro 
                165                 170                 175     


Glu Pro Leu Thr Val Trp Arg Asp Pro Tyr Gly Glu Val Val Pro Ala 
            180                 185                 190         


Leu Lys Glu Val Ser Ile Ala Asp Ala Asp Gly Leu Phe Met Val Thr 
        195                 200                 205             


Thr Ala Val Ile Ile Arg Asp Lys Tyr Val Arg Asn Val Ser Cys Ser 
    210                 215                 220                 


Val Asn Asn Thr Leu Leu Gly Gln Glu Lys Glu Thr Val Ile Phe Ile 
225                 230                 235                 240 


Pro Glu Ser Phe Met Pro Ser Ala Ser Pro Trp Met Val Ala Leu Ala 
                245                 250                 255     


Val Ile Leu Thr Ala Ser Pro Trp Met Val Ser Met Thr Val Ile Leu 
            260                 265                 270         


Ala Val Phe Ile Ile Phe Met Ala Val Ser Ile Cys Cys Ile Lys Lys 
        275                 280                 285             


Leu Gln Arg Glu Lys Lys Ile Leu Ser Gly Glu Lys Lys Val Glu Gln 
    290                 295                 300                 


Glu Glu Lys Glu Ile Ala Gln Gln Leu Gln Glu Glu Leu Arg Trp Arg 
305                 310                 315                 320 


Arg Thr Phe Leu His Ala Ala Asp Val Val Leu Asp Pro Asp Thr Ala 
                325                 330                 335     


His Pro Glu Leu Phe Leu Ser Glu Asp Arg Arg Ser Val Arg Arg Gly 
            340                 345                 350         


Pro Tyr Arg Gln Arg Val Pro Asp Asn Pro Glu Arg Phe Asp Ser Gln 
        355                 360                 365             


Pro Cys Val Leu Gly Trp Glu Ser Phe Ala Ser Gly Lys His Tyr Trp 
    370                 375                 380                 


Glu Val Glu Val Glu Asn Val Met Val Trp Thr Val Gly Val Cys Arg 
385                 390                 395                 400 


His Ser Val Glu Arg Lys Gly Glu Val Leu Leu Ile Pro Gln Asn Gly 
                405                 410                 415     


Phe Trp Thr Leu Glu Met Phe Gly Asn Gln Tyr Arg Ala Leu Ser Ser 
            420                 425                 430         


Pro Glu Arg Ile Leu Pro Leu Lys Glu Ser Leu Cys Arg Val Gly Val 
        435                 440                 445             


Phe Leu Asp Tyr Glu Ala Gly Asp Val Ser Phe Tyr Asn Met Arg Asp 
    450                 455                 460                 


Arg Ser His Ile Tyr Thr Cys Pro Arg Ser Ala Phe Thr Val Pro Val 
465                 470                 475                 480 


Arg Pro Phe Phe Arg Leu Gly Ser Asp Asp Ser Pro Ile Phe Ile Cys 
                485                 490                 495     


Pro Ala Leu Thr Gly Ala Ser Gly Val Met Val Pro Glu Glu Gly Leu 
            500                 505                 510         


Lys Leu His Arg Val Gly Thr His Gln Ser Leu 
        515                 520             


<210>  1615
<211>  313
<212>  PRT
<213>  Homo Sapiens

<400>  1615

Met Glu Pro Ala Ala Ala Leu His Phe Ser Leu Pro Ala Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Ser Leu Cys Ala Leu Val Ser Glu 
            20                  25                  30          


Ser Phe Met Pro Ser Ala Ser Pro Trp Met Val Ala Leu Ala Val Ile 
        35                  40                  45              


Leu Thr Ala Ser Pro Trp Met Val Ser Met Thr Val Ile Leu Ala Val 
    50                  55                  60                  


Phe Ile Ile Phe Met Ala Val Ser Ile Cys Cys Ile Lys Lys Leu Gln 
65                  70                  75                  80  


Arg Glu Lys Lys Ile Leu Ser Gly Glu Lys Lys Val Glu Gln Glu Glu 
                85                  90                  95      


Lys Glu Ile Ala Gln Gln Leu Gln Glu Glu Leu Arg Trp Arg Arg Thr 
            100                 105                 110         


Phe Leu His Ala Ala Asp Val Val Leu Asp Pro Asp Thr Ala His Pro 
        115                 120                 125             


Glu Leu Phe Leu Ser Glu Asp Arg Arg Ser Val Arg Arg Gly Pro Tyr 
    130                 135                 140                 


Arg Gln Arg Val Pro Asp Asn Pro Glu Arg Phe Asp Ser Gln Pro Cys 
145                 150                 155                 160 


Val Leu Gly Trp Glu Ser Phe Ala Ser Gly Lys His Tyr Trp Glu Val 
                165                 170                 175     


Glu Val Glu Asn Val Met Val Trp Thr Val Gly Val Cys Arg His Ser 
            180                 185                 190         


Val Glu Arg Lys Gly Glu Val Leu Leu Ile Pro Gln Asn Gly Phe Trp 
        195                 200                 205             


Thr Leu Glu Met Phe Gly Asn Gln Tyr Arg Ala Leu Ser Ser Pro Glu 
    210                 215                 220                 


Arg Ile Leu Pro Leu Lys Glu Ser Leu Cys Arg Val Gly Val Phe Leu 
225                 230                 235                 240 


Asp Tyr Glu Ala Gly Asp Val Ser Phe Tyr Asn Met Arg Asp Arg Ser 
                245                 250                 255     


His Ile Tyr Thr Cys Pro Arg Ser Ala Phe Thr Val Pro Val Arg Pro 
            260                 265                 270         


Phe Phe Arg Leu Gly Ser Asp Asp Ser Pro Ile Phe Ile Cys Pro Ala 
        275                 280                 285             


Leu Thr Gly Ala Ser Gly Val Met Val Pro Glu Glu Gly Leu Lys Leu 
    290                 295                 300                 


His Arg Val Gly Thr His Gln Ser Leu 
305                 310             


<210>  1616
<211>  110
<212>  PRT
<213>  Homo Sapiens

<400>  1616

Met Glu Pro Ala Ala Ala Leu His Phe Ser Leu Pro Ala Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Ser Leu Cys Ala Leu Val Ser Gly 
            20                  25                  30          


Leu Gly Ser Lys Pro Leu Ile Glu Ile Lys Ala Gln Glu Asp Gly Ser 
        35                  40                  45              


Ile Trp Leu Glu Cys Ile Ser Gly Gly Trp Tyr Pro Glu Pro Leu Thr 
    50                  55                  60                  


Val Trp Arg Asp Pro Tyr Gly Glu Val Val Pro Ala Leu Lys Glu Val 
65                  70                  75                  80  


Ser Ile Ala Asp Ala Asp Gly Leu Phe Met Val Thr Thr Ala Val Ile 
                85                  90                  95      


Ile Arg Asp Lys Tyr Val Arg Asn Val Ser Cys Ser Val Asn 
            100                 105                 110 


<210>  1617
<211>  184
<212>  PRT
<213>  Homo Sapiens

<400>  1617

Met Glu Pro Ala Ala Ala Leu His Phe Ser Leu Pro Ala Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Ser Leu Cys Ala Leu Val Ser Gly 
            20                  25                  30          


Leu Gly Ser Lys Pro Leu Ile Glu Ile Lys Ala Gln Glu Asp Gly Ser 
        35                  40                  45              


Ile Trp Leu Glu Cys Ile Ser Gly Gly Trp Tyr Pro Glu Pro Leu Thr 
    50                  55                  60                  


Val Trp Arg Asp Pro Tyr Gly Glu Val Val Pro Ala Leu Lys Glu Val 
65                  70                  75                  80  


Ser Ile Ala Asp Ala Asp Gly Leu Phe Met Val Thr Thr Ala Val Ile 
                85                  90                  95      


Ile Arg Asp Lys Tyr Val Arg Asn Val Ser Cys Ser Val Asn Asn Thr 
            100                 105                 110         


Leu Leu Gly Gln Glu Lys Glu Thr Val Ile Phe Ile Pro Glu Ser Phe 
        115                 120                 125             


Met Pro Ser Ala Ser Pro Trp Met Val Ala Leu Ala Val Ile Leu Thr 
    130                 135                 140                 


Ala Ser Pro Trp Met Val Ser Met Thr Val Ile Leu Ala Val Phe Ile 
145                 150                 155                 160 


Ile Phe Met Ala Val Ser Ile Cys Cys Ile Lys Lys Leu Gln Arg Glu 
                165                 170                 175     


Lys Lys Ile Leu Ser Gly Glu Lys 
            180                 


<210>  1618
<211>  407
<212>  PRT
<213>  Homo Sapiens

<400>  1618

Met Glu Pro Ala Ala Ala Leu His Phe Ser Leu Pro Ala Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Ser Leu Cys Ala Leu Val Ser Gly 
            20                  25                  30          


Leu Gly Ser Lys Pro Leu Ile Glu Ile Lys Ala Gln Glu Asp Gly Ser 
        35                  40                  45              


Ile Trp Leu Glu Cys Ile Ser Gly Gly Trp Tyr Pro Glu Pro Leu Thr 
    50                  55                  60                  


Val Trp Arg Asp Pro Tyr Gly Glu Val Val Pro Ala Leu Lys Glu Val 
65                  70                  75                  80  


Ser Ile Ala Asp Ala Asp Gly Leu Phe Met Val Thr Thr Ala Val Ile 
                85                  90                  95      


Ile Arg Asp Lys Tyr Val Arg Asn Val Ser Cys Ser Val Asn Asn Thr 
            100                 105                 110         


Leu Leu Gly Gln Glu Lys Glu Thr Val Ile Phe Ile Pro Glu Ser Phe 
        115                 120                 125             


Met Pro Ser Ala Ser Pro Trp Met Val Ala Leu Ala Val Ile Leu Thr 
    130                 135                 140                 


Ala Ser Pro Trp Met Val Ser Met Thr Val Ile Leu Ala Val Phe Ile 
145                 150                 155                 160 


Ile Phe Met Ala Val Ser Ile Cys Cys Ile Lys Lys Leu Gln Arg Glu 
                165                 170                 175     


Lys Lys Ile Leu Ser Gly Glu Lys Lys Val Glu Gln Glu Glu Lys Glu 
            180                 185                 190         


Ile Ala Gln Gln Leu Gln Glu Glu Leu Arg Trp Arg Arg Thr Phe Leu 
        195                 200                 205             


His Ala Ala Asp Val Val Leu Asp Pro Asp Thr Ala His Pro Glu Leu 
    210                 215                 220                 


Phe Leu Ser Glu Asp Arg Arg Ser Val Arg Arg Gly Pro Tyr Arg Gln 
225                 230                 235                 240 


Arg Val Pro Asp Asn Pro Glu Arg Phe Asp Ser Gln Pro Cys Val Leu 
                245                 250                 255     


Gly Trp Glu Ser Phe Ala Ser Gly Lys His Tyr Trp Glu Val Glu Val 
            260                 265                 270         


Glu Asn Val Met Val Trp Thr Val Gly Val Cys Arg His Ser Val Glu 
        275                 280                 285             


Arg Lys Gly Glu Val Leu Leu Ile Pro Gln Asn Gly Phe Trp Thr Leu 
    290                 295                 300                 


Glu Met Phe Gly Asn Gln Tyr Arg Ala Leu Ser Ser Pro Glu Arg Ile 
305                 310                 315                 320 


Leu Pro Leu Lys Glu Ser Leu Cys Arg Val Gly Val Phe Leu Asp Tyr 
                325                 330                 335     


Glu Ala Gly Asp Val Ser Phe Tyr Asn Met Arg Asp Arg Ser His Ile 
            340                 345                 350         


Tyr Thr Cys Pro Arg Ser Ala Phe Thr Val Pro Val Arg Pro Phe Phe 
        355                 360                 365             


Arg Leu Gly Ser Asp Asp Ser Pro Ile Phe Ile Cys Pro Ala Leu Thr 
    370                 375                 380                 


Gly Ala Ser Gly Val Met Val Pro Glu Glu Gly Leu Lys Leu His Arg 
385                 390                 395                 400 


Val Gly Thr His Gln Ser Leu 
                405         


<210>  1619
<211>  39
<212>  PRT
<213>  Homo Sapiens

<400>  1619

Met Glu Pro Ala Ala Ala Leu His Phe Ser Leu Pro Ala Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Ser Leu Cys Ala Leu Val Ser Val 
            20                  25                  30          


Leu Pro Arg Ser Val Cys Val 
        35                  


<210>  1620
<211>  80
<212>  PRT
<213>  Homo Sapiens

<400>  1620

Met Val Thr Thr Ala Val Ile Ile Arg Asp Lys Tyr Val Arg Asn Val 
1               5                   10                  15      


Ser Cys Ser Val Asn Asn Thr Leu Leu Gly Gln Glu Lys Glu Thr Val 
            20                  25                  30          


Ile Phe Ile Pro Glu Ser Phe Met Pro Ser Ala Ser Pro Trp Met Val 
        35                  40                  45              


Ala Leu Ala Val Ile Leu Thr Ala Ser Pro Trp Met Val Ser Met Thr 
    50                  55                  60                  


Val Ile Leu Ala Val Phe Ile Ile Phe Met Ala Val Ser Ile Cys Cys 
65                  70                  75                  80  


<210>  1621
<211>  237
<212>  PRT
<213>  Homo Sapiens

<400>  1621

Met Val Thr Thr Ala Val Ile Ile Arg Asp Lys Tyr Val Arg Asn Val 
1               5                   10                  15      


Ser Cys Ser Val Asn Asn Thr Leu Leu Gly Gln Glu Lys Glu Thr Val 
            20                  25                  30          


Ile Phe Ile Pro Glu Ser Phe Met Pro Ser Ala Ser Pro Trp Met Val 
        35                  40                  45              


Ala Leu Ala Val Ile Leu Thr Ala Ser Pro Trp Met Val Ser Met Thr 
    50                  55                  60                  


Val Ile Leu Ala Val Phe Ile Ile Phe Met Ala Val Ser Ile Cys Cys 
65                  70                  75                  80  


Ile Lys Lys Leu Gln Arg Glu Lys Lys Ile Leu Ser Gly Glu Lys Lys 
                85                  90                  95      


Val Glu Gln Glu Glu Lys Glu Ile Ala Gln Gln Leu Gln Glu Glu Leu 
            100                 105                 110         


Arg Trp Arg Arg Thr Phe Leu His Ala Ala Asp Val Val Leu Asp Pro 
        115                 120                 125             


Asp Thr Ala His Pro Glu Leu Phe Leu Ser Glu Asp Arg Arg Ser Val 
    130                 135                 140                 


Arg Arg Gly Pro Tyr Arg Gln Arg Val Pro Asp Asn Pro Glu Arg Phe 
145                 150                 155                 160 


Asp Ser Gln Pro Cys Val Leu Gly Trp Glu Ser Phe Ala Ser Gly Lys 
                165                 170                 175     


His Tyr Trp Glu Val Glu Val Glu Asn Val Met Val Trp Thr Val Gly 
            180                 185                 190         


Val Cys Arg His Ser Val Glu Arg Lys Gly Glu Val Leu Leu Ile Pro 
        195                 200                 205             


Gln Asn Gly Phe Trp Thr Leu Glu Met Phe Gly Asn Gln Tyr Arg Ala 
    210                 215                 220                 


Leu Ser Ser Pro Glu Arg Ile Leu Pro Leu Lys Glu Ser 
225                 230                 235         


<210>  1622
<211>  43
<212>  PRT
<213>  Homo Sapiens

<400>  1622

Met Lys Met Ala Ser Phe Leu Ala Phe Leu Leu Leu Asn Phe Arg Val 
1               5                   10                  15      


Cys Leu Leu Leu Leu Gln Leu Leu Met Pro His Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met 
        35                  40              


<210>  1623
<211>  92
<212>  PRT
<213>  Homo Sapiens

<400>  1623

Met Lys Met Ala Ser Phe Leu Ala Phe Leu Leu Leu Asn Phe Arg Val 
1               5                   10                  15      


Cys Leu Leu Leu Leu Gln Leu Leu Met Pro His Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu 
    50                  55                  60                  


Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro 
                85                  90          


<210>  1624
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  1624

Met Lys Met Ala Ser Phe Leu Ala Phe Leu Leu Leu Asn Phe Arg Val 
1               5                   10                  15      


Cys Leu Leu Leu Leu Gln Leu Leu Met Pro His Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu 
    50                  55                  60                  


Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Thr Ala Ser 
        115                 


<210>  1625
<211>  513
<212>  PRT
<213>  Homo Sapiens

<400>  1625

Met Lys Met Ala Ser Phe Leu Ala Phe Leu Leu Leu Asn Phe Arg Val 
1               5                   10                  15      


Cys Leu Leu Leu Leu Gln Leu Leu Met Pro His Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu 
    50                  55                  60                  


Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe 
        115                 120                 125             


Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala 
    130                 135                 140                 


Ala Leu Gly Ser Asp Leu His Val Asp Val Lys Gly Tyr Lys Asp Gly 
145                 150                 155                 160 


Gly Ile His Leu Glu Cys Arg Ser Thr Gly Trp Tyr Pro Gln Pro Gln 
                165                 170                 175     


Ile Gln Trp Ser Asn Asn Lys Gly Glu Asn Ile Pro Thr Val Glu Ala 
            180                 185                 190         


Pro Val Val Ala Asp Gly Val Gly Leu Tyr Ala Val Ala Ala Ser Val 
        195                 200                 205             


Ile Met Arg Gly Ser Ser Gly Glu Gly Val Ser Cys Thr Ile Arg Ser 
    210                 215                 220                 


Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala Asp Pro 
225                 230                 235                 240 


Phe Phe Arg Ser Ala Gln Arg Trp Ile Ala Ala Leu Ala Gly Thr Leu 
                245                 250                 255     


Pro Val Leu Leu Leu Leu Leu Gly Gly Ala Gly Tyr Phe Leu Trp Gln 
            260                 265                 270         


Gln Gln Glu Glu Lys Lys Thr Gln Phe Arg Lys Lys Lys Arg Glu Gln 
        275                 280                 285             


Glu Leu Arg Glu Met Ala Trp Ser Thr Met Lys Gln Glu Gln Ser Thr 
    290                 295                 300                 


Arg Val Lys Leu Leu Glu Glu Leu Arg Trp Arg Ser Ile Gln Tyr Ala 
305                 310                 315                 320 


Ser Arg Gly Glu Arg His Ser Ala Tyr Asn Glu Trp Lys Lys Ala Leu 
                325                 330                 335     


Phe Lys Pro Ala Asp Val Ile Leu Asp Pro Lys Thr Ala Asn Pro Ile 
            340                 345                 350         


Leu Leu Val Ser Glu Asp Gln Arg Ser Val Gln Arg Ala Lys Glu Pro 
        355                 360                 365             


Gln Asp Leu Pro Asp Asn Pro Glu Arg Phe Asn Trp His Tyr Cys Val 
    370                 375                 380                 


Leu Gly Cys Glu Ser Phe Ile Ser Gly Arg His Tyr Trp Glu Val Glu 
385                 390                 395                 400 


Val Gly Asp Arg Lys Glu Trp His Ile Gly Val Cys Ser Lys Asn Val 
                405                 410                 415     


Gln Arg Lys Gly Trp Val Lys Met Thr Pro Glu Asn Gly Phe Trp Thr 
            420                 425                 430         


Met Gly Leu Thr Asp Gly Asn Lys Tyr Arg Thr Leu Thr Glu Pro Arg 
        435                 440                 445             


Thr Asn Leu Lys Leu Pro Lys Pro Pro Lys Lys Val Gly Val Phe Leu 
    450                 455                 460                 


Asp Tyr Glu Thr Gly Asp Ile Ser Phe Tyr Asn Ala Val Asp Gly Ser 
465                 470                 475                 480 


His Ile His Thr Phe Leu Asp Val Ser Phe Ser Glu Ala Leu Tyr Pro 
                485                 490                 495     


Val Phe Arg Ile Leu Thr Leu Glu Pro Thr Ala Leu Thr Ile Cys Pro 
            500                 505                 510         


Ala 
    


<210>  1626
<211>  352
<212>  PRT
<213>  Homo Sapiens

<400>  1626

Met Lys Met Ala Ser Phe Leu Ala Phe Leu Leu Leu Asn Phe Arg Val 
1               5                   10                  15      


Cys Leu Leu Leu Leu Gln Leu Leu Met Pro His Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu 
    50                  55                  60                  


Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe 
        115                 120                 125             


Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala 
    130                 135                 140                 


Ala Leu Gly Ser Asp Leu His Val Asp Val Lys Gly Tyr Lys Asp Gly 
145                 150                 155                 160 


Gly Ile His Leu Glu Cys Arg Ser Thr Gly Trp Tyr Pro Gln Pro Gln 
                165                 170                 175     


Ile Gln Trp Ser Asn Asn Lys Gly Glu Asn Ile Pro Thr Val Glu Ala 
            180                 185                 190         


Pro Val Val Ala Asp Gly Val Gly Leu Tyr Ala Val Ala Ala Ser Val 
        195                 200                 205             


Ile Met Arg Gly Ser Ser Gly Glu Gly Val Ser Cys Thr Ile Arg Ser 
    210                 215                 220                 


Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala Asp Pro 
225                 230                 235                 240 


Phe Phe Arg Ser Ala Gln Arg Trp Ile Ala Ala Leu Ala Gly Thr Leu 
                245                 250                 255     


Pro Val Leu Leu Leu Leu Leu Gly Gly Ala Gly Tyr Phe Leu Trp Gln 
            260                 265                 270         


Gln Gln Glu Glu Lys Lys Thr Gln Phe Arg Lys Lys Lys Arg Glu Gln 
        275                 280                 285             


Glu Leu Arg Glu Met Ala Trp Ser Thr Met Lys Gln Glu Gln Ser Thr 
    290                 295                 300                 


Arg Val Lys Leu Leu Glu Glu Leu Arg Trp Arg Ser Ile Gln Tyr Ala 
305                 310                 315                 320 


Ser Arg Gly Glu Arg His Ser Ala Tyr Asn Glu Trp Lys Lys Ala Leu 
                325                 330                 335     


Phe Lys Pro Gly Glu Glu Met Leu Gln Met Arg Leu His Phe Val Lys 
            340                 345                 350         


<210>  1627
<211>  378
<212>  PRT
<213>  Homo Sapiens

<400>  1627

Met Lys Met Ala Ser Phe Leu Ala Phe Leu Leu Leu Asn Phe Arg Val 
1               5                   10                  15      


Cys Leu Leu Leu Leu Gln Leu Leu Met Pro His Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu 
    50                  55                  60                  


Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe 
        115                 120                 125             


Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala 
    130                 135                 140                 


Ala Leu Gly Ser Asp Leu His Val Asp Val Lys Gly Tyr Lys Asp Gly 
145                 150                 155                 160 


Gly Ile His Leu Glu Cys Arg Ser Thr Gly Trp Tyr Pro Gln Pro Gln 
                165                 170                 175     


Ile Gln Trp Ser Asn Asn Lys Gly Glu Asn Ile Pro Thr Val Glu Ala 
            180                 185                 190         


Pro Val Val Ala Asp Gly Val Gly Leu Tyr Ala Val Ala Ala Ser Val 
        195                 200                 205             


Ile Met Arg Gly Ser Ser Gly Glu Gly Val Ser Cys Thr Ile Arg Ser 
    210                 215                 220                 


Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala Asp Pro 
225                 230                 235                 240 


Phe Phe Arg Ser Ala Gln Arg Trp Ile Ala Ala Leu Ala Gly Thr Leu 
                245                 250                 255     


Pro Val Leu Leu Leu Leu Leu Gly Gly Ala Gly Tyr Phe Leu Trp Gln 
            260                 265                 270         


Gln Gln Glu Glu Lys Lys Thr Gln Phe Arg Lys Lys Lys Arg Glu Gln 
        275                 280                 285             


Glu Leu Arg Glu Met Ala Trp Ser Thr Met Lys Gln Glu Gln Ser Thr 
    290                 295                 300                 


Arg Val Lys Leu Leu Glu Glu Leu Arg Trp Arg Ser Ile Gln Tyr Ala 
305                 310                 315                 320 


Ser Arg Gly Glu Arg His Ser Ala Tyr Asn Glu Trp Lys Lys Ala Leu 
                325                 330                 335     


Phe Lys Pro Gly Pro Pro Ile Gly Gln Thr Gln Gln Gln Thr Arg Gly 
            340                 345                 350         


Gln Gly Ser Pro Val Ala Leu Ser Gln Glu Ser Ala Gln Arg Thr Asp 
        355                 360                 365             


Ser Trp Gly Pro Glu Glu Gly Gly Glu Ser 
    370                 375             


<210>  1628
<211>  461
<212>  PRT
<213>  Homo Sapiens

<400>  1628

Met Lys Met Ala Ser Phe Leu Ala Phe Leu Leu Leu Asn Phe Arg Val 
1               5                   10                  15      


Cys Leu Leu Leu Leu Gln Leu Leu Met Pro His Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu 
    50                  55                  60                  


Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe 
        115                 120                 125             


Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala 
    130                 135                 140                 


Asp Gly Val Gly Leu Tyr Ala Val Ala Ala Ser Val Ile Met Arg Gly 
145                 150                 155                 160 


Ser Ser Gly Glu Gly Val Ser Cys Thr Ile Arg Ser Ser Leu Leu Gly 
                165                 170                 175     


Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala Asp Pro Phe Phe Arg Ser 
            180                 185                 190         


Ala Gln Arg Trp Ile Ala Ala Leu Ala Gly Thr Leu Pro Val Leu Leu 
        195                 200                 205             


Leu Leu Leu Gly Gly Ala Gly Tyr Phe Leu Trp Gln Gln Gln Glu Glu 
    210                 215                 220                 


Lys Lys Thr Gln Phe Arg Lys Lys Lys Arg Glu Gln Glu Leu Arg Glu 
225                 230                 235                 240 


Met Ala Trp Ser Thr Met Lys Gln Glu Gln Ser Thr Arg Val Lys Leu 
                245                 250                 255     


Leu Glu Glu Leu Arg Trp Arg Ser Ile Gln Tyr Ala Ser Arg Gly Glu 
            260                 265                 270         


Arg His Ser Ala Tyr Asn Glu Trp Lys Lys Ala Leu Phe Lys Pro Ala 
        275                 280                 285             


Asp Val Ile Leu Asp Pro Lys Thr Ala Asn Pro Ile Leu Leu Val Ser 
    290                 295                 300                 


Glu Asp Gln Arg Ser Val Gln Arg Ala Lys Glu Pro Gln Asp Leu Pro 
305                 310                 315                 320 


Asp Asn Pro Glu Arg Phe Asn Trp His Tyr Cys Val Leu Gly Cys Glu 
                325                 330                 335     


Ser Phe Ile Ser Gly Arg His Tyr Trp Glu Val Glu Val Gly Asp Arg 
            340                 345                 350         


Lys Glu Trp His Ile Gly Val Cys Ser Lys Asn Val Gln Arg Lys Gly 
        355                 360                 365             


Trp Val Lys Met Thr Pro Glu Asn Gly Phe Trp Thr Met Gly Leu Thr 
    370                 375                 380                 


Asp Gly Asn Lys Tyr Arg Thr Leu Thr Glu Pro Arg Thr Asn Leu Lys 
385                 390                 395                 400 


Leu Pro Lys Pro Pro Lys Lys Val Gly Val Phe Leu Asp Tyr Glu Thr 
                405                 410                 415     


Gly Asp Ile Ser Phe Tyr Asn Ala Val Asp Gly Ser His Ile His Thr 
            420                 425                 430         


Phe Leu Asp Val Ser Phe Ser Glu Ala Leu Tyr Pro Val Phe Arg Ile 
        435                 440                 445             


Leu Thr Leu Glu Pro Thr Ala Leu Thr Ile Cys Pro Ala 
    450                 455                 460     


<210>  1629
<211>  311
<212>  PRT
<213>  Homo Sapiens

<400>  1629

Met Gly Ile Pro Arg Ala Gln Phe Ser Val Leu Gly Pro Ser Gly Pro 
1               5                   10                  15      


Ile Leu Ala Met Val Gly Glu Asp Ala Asp Leu Pro Cys His Leu Phe 
            20                  25                  30          


Pro Thr Met Ser Ala Glu Thr Met Glu Leu Lys Trp Val Ser Ser Ser 
        35                  40                  45              


Leu Arg Gln Val Val Asn Val Tyr Ala Asp Gly Lys Glu Val Glu Asp 
    50                  55                  60                  


Arg Gln Ser Ala Pro Tyr Arg Gly Arg Thr Ser Ile Leu Arg Asp Gly 
65                  70                  75                  80  


Ile Thr Ala Gly Lys Ala Ala Leu Arg Ile His Asn Val Thr Ala Ser 
                85                  90                  95      


Asp Ser Gly Lys Tyr Leu Cys Tyr Phe Gln Asp Gly Asp Phe Tyr Glu 
            100                 105                 110         


Lys Ala Leu Val Glu Leu Lys Val Ala Ala Leu Gly Ser Asn Leu His 
        115                 120                 125             


Val Glu Val Lys Gly Tyr Glu Asp Gly Gly Ile His Leu Glu Cys Arg 
    130                 135                 140                 


Ser Thr Gly Trp Tyr Pro Gln Pro Gln Ile Gln Trp Ser Asn Ala Lys 
145                 150                 155                 160 


Gly Glu Asn Ile Pro Ala Val Glu Ala Pro Val Val Ala Asp Gly Val 
                165                 170                 175     


Gly Leu Tyr Glu Val Ala Ala Ser Val Ile Met Arg Gly Gly Ser Gly 
            180                 185                 190         


Glu Gly Val Ser Cys Ile Ile Arg Asn Ser Leu Leu Gly Leu Glu Lys 
        195                 200                 205             


Thr Ala Ser Ile Ser Ile Ala Asp Pro Phe Phe Arg Ser Ala Gln Pro 
    210                 215                 220                 


Trp Ile Ala Ala Leu Ala Gly Thr Leu Pro Ile Leu Leu Leu Leu Leu 
225                 230                 235                 240 


Ala Gly Ala Ser Tyr Phe Leu Trp Arg Gln Gln Lys Glu Ile Thr Ala 
                245                 250                 255     


Leu Ser Ser Glu Ile Glu Ser Glu Gln Glu Met Lys Glu Met Gly Tyr 
            260                 265                 270         


Ala Ala Thr Glu Arg Glu Ile Ser Leu Arg Glu Ser Leu Gln Glu Glu 
        275                 280                 285             


Leu Lys Arg Lys Lys Ile Gln Tyr Leu Thr Arg Gly Glu Glu Ser Ser 
    290                 295                 300                 


Ser Asp Thr Asn Lys Ser Ala 
305                 310     


<210>  1630
<211>  334
<212>  PRT
<213>  Homo Sapiens

<400>  1630

Met Lys Met Ala Ser Ser Leu Ala Phe Leu Leu Leu Asn Phe His Val 
1               5                   10                  15      


Ser Leu Leu Leu Val Gln Leu Leu Thr Pro Cys Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu 
    50                  55                  60                  


Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe 
        115                 120                 125             


Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala 
    130                 135                 140                 


Ala Leu Gly Ser Asn Leu His Val Glu Val Lys Gly Tyr Glu Asp Gly 
145                 150                 155                 160 


Gly Ile His Leu Glu Cys Arg Ser Thr Gly Trp Tyr Pro Gln Pro Gln 
                165                 170                 175     


Ile Gln Trp Ser Asn Ala Lys Gly Glu Asn Ile Pro Ala Val Glu Ala 
            180                 185                 190         


Pro Val Val Ala Asp Gly Val Gly Leu Tyr Glu Val Ala Ala Ser Val 
        195                 200                 205             


Ile Met Arg Gly Gly Ser Gly Glu Gly Val Ser Cys Ile Ile Arg Asn 
    210                 215                 220                 


Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala Asp Pro 
225                 230                 235                 240 


Phe Phe Arg Ser Ala Gln Pro Trp Ile Ala Ala Leu Ala Gly Thr Leu 
                245                 250                 255     


Pro Ile Leu Leu Leu Leu Leu Ala Gly Ala Ser Tyr Phe Leu Trp Arg 
            260                 265                 270         


Gln Gln Lys Glu Ile Thr Ala Leu Ser Ser Glu Ile Glu Ser Glu Gln 
        275                 280                 285             


Glu Met Lys Glu Met Gly Tyr Ala Ala Thr Glu Arg Glu Ile Ser Leu 
    290                 295                 300                 


Arg Glu Ser Leu Gln Glu Glu Leu Lys Arg Lys Lys Ile Gln Tyr Leu 
305                 310                 315                 320 


Thr Arg Gly Glu Glu Ser Ser Ser Asp Thr Asn Lys Ser Ala 
                325                 330                 


<210>  1631
<211>  334
<212>  PRT
<213>  Homo Sapiens

<400>  1631

Met Lys Met Ala Ser Ser Leu Ala Phe Leu Leu Leu Asn Phe His Val 
1               5                   10                  15      


Ser Leu Leu Leu Val Gln Leu Leu Thr Pro Cys Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu 
    50                  55                  60                  


Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe 
        115                 120                 125             


Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala 
    130                 135                 140                 


Ala Leu Gly Ser Asn Leu His Val Glu Val Lys Gly Tyr Glu Asp Gly 
145                 150                 155                 160 


Gly Ile His Leu Glu Cys Arg Ser Thr Gly Trp Tyr Pro Gln Pro Gln 
                165                 170                 175     


Ile Gln Trp Ser Asn Ala Lys Gly Glu Asn Ile Pro Ala Val Glu Ala 
            180                 185                 190         


Pro Val Val Ala Asp Gly Val Gly Leu Tyr Glu Val Ala Ala Ser Val 
        195                 200                 205             


Ile Met Arg Gly Gly Ser Gly Glu Gly Val Ser Cys Ile Ile Arg Asn 
    210                 215                 220                 


Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala Asp Pro 
225                 230                 235                 240 


Phe Phe Arg Ser Ala Gln Pro Trp Ile Ala Ala Leu Ala Gly Thr Leu 
                245                 250                 255     


Pro Ile Leu Leu Leu Leu Leu Ala Gly Ala Ser Tyr Phe Leu Trp Arg 
            260                 265                 270         


Gln Gln Lys Glu Ile Thr Ala Leu Ser Ser Glu Ile Glu Ser Glu Gln 
        275                 280                 285             


Glu Met Lys Glu Met Gly Tyr Ala Ala Thr Glu Arg Glu Ile Ser Leu 
    290                 295                 300                 


Arg Glu Ser Leu Gln Glu Glu Leu Lys Arg Lys Lys Ile Gln Tyr Leu 
305                 310                 315                 320 


Thr Arg Gly Glu Glu Ser Ser Ser Asp Thr Asn Lys Ser Ala 
                325                 330                 


<210>  1632
<211>  334
<212>  PRT
<213>  Homo Sapiens

<400>  1632

Met Lys Met Ala Ser Ser Leu Ala Phe Leu Leu Leu Asn Phe His Val 
1               5                   10                  15      


Ser Leu Leu Leu Val Gln Leu Leu Thr Pro Cys Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu 
    50                  55                  60                  


Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe 
        115                 120                 125             


Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala 
    130                 135                 140                 


Ala Leu Gly Ser Asn Leu His Val Glu Val Lys Gly Tyr Glu Asp Gly 
145                 150                 155                 160 


Gly Ile His Leu Glu Cys Arg Ser Thr Gly Trp Tyr Pro Gln Pro Gln 
                165                 170                 175     


Ile Gln Trp Ser Asn Ala Lys Gly Glu Asn Ile Pro Ala Val Glu Ala 
            180                 185                 190         


Pro Val Val Ala Asp Gly Val Gly Leu Tyr Glu Val Ala Ala Ser Val 
        195                 200                 205             


Ile Met Arg Gly Gly Ser Gly Glu Gly Val Ser Cys Ile Ile Arg Asn 
    210                 215                 220                 


Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala Asp Pro 
225                 230                 235                 240 


Phe Phe Arg Ser Ala Gln Pro Trp Ile Ala Ala Leu Ala Gly Thr Leu 
                245                 250                 255     


Pro Ile Leu Leu Leu Leu Leu Ala Gly Ala Ser Tyr Phe Leu Trp Arg 
            260                 265                 270         


Gln Gln Lys Glu Ile Thr Ala Leu Ser Ser Glu Ile Glu Ser Glu Gln 
        275                 280                 285             


Glu Met Lys Glu Met Gly Tyr Ala Ala Thr Glu Arg Glu Ile Ser Leu 
    290                 295                 300                 


Arg Glu Ser Leu Gln Glu Glu Leu Lys Arg Lys Lys Ile Gln Tyr Leu 
305                 310                 315                 320 


Thr Arg Gly Glu Glu Ser Ser Ser Asp Thr Asn Lys Ser Ala 
                325                 330                 


<210>  1633
<211>  334
<212>  PRT
<213>  Homo Sapiens

<400>  1633

Met Lys Met Ala Ser Ser Leu Ala Phe Leu Leu Leu Asn Phe His Val 
1               5                   10                  15      


Ser Leu Leu Leu Val Gln Leu Leu Thr Pro Cys Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu 
    50                  55                  60                  


Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe 
        115                 120                 125             


Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala 
    130                 135                 140                 


Ala Leu Gly Ser Asn Leu His Val Glu Val Lys Gly Tyr Glu Asp Gly 
145                 150                 155                 160 


Gly Ile His Leu Glu Cys Arg Ser Thr Gly Trp Tyr Pro Gln Pro Gln 
                165                 170                 175     


Ile Gln Trp Ser Asn Ala Lys Gly Glu Asn Ile Pro Ala Val Glu Ala 
            180                 185                 190         


Pro Val Val Ala Asp Gly Val Gly Leu Tyr Glu Val Ala Ala Ser Val 
        195                 200                 205             


Ile Met Arg Gly Gly Ser Gly Glu Gly Val Ser Cys Ile Ile Arg Asn 
    210                 215                 220                 


Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala Asp Pro 
225                 230                 235                 240 


Phe Phe Arg Ser Ala Gln Pro Trp Ile Ala Ala Leu Ala Gly Thr Leu 
                245                 250                 255     


Pro Ile Leu Leu Leu Leu Leu Ala Gly Ala Ser Tyr Phe Leu Trp Arg 
            260                 265                 270         


Gln Gln Lys Glu Ile Thr Ala Leu Ser Ser Glu Ile Glu Ser Glu Gln 
        275                 280                 285             


Glu Met Lys Glu Met Gly Tyr Ala Ala Thr Glu Arg Glu Ile Ser Leu 
    290                 295                 300                 


Arg Glu Ser Leu Gln Glu Glu Leu Lys Arg Lys Lys Ile Gln Tyr Leu 
305                 310                 315                 320 


Thr Arg Gly Glu Glu Ser Ser Ser Asp Thr Asn Lys Ser Ala 
                325                 330                 


<210>  1634
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  1634

Met Lys Met Ala Ser Ser Leu Ala Phe Leu Leu Leu Asn Phe His Val 
1               5                   10                  15      


Ser Leu Leu Leu Val Gln Leu Leu Thr Pro Cys Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu 
    50                  55                  60                  


Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe 
        115                 120                 125             


Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala 
    130                 135                 140                 


Asp Pro Phe Phe Arg Ser Ala Gln Pro Trp Ile Ala Ala Leu Ala Gly 
145                 150                 155                 160 


<210>  1635
<211>  43
<212>  PRT
<213>  Homo Sapiens

<400>  1635

Met Lys Met Ala Ser Ser Leu Ala Phe Leu Leu Leu Asn Phe His Val 
1               5                   10                  15      


Ser Leu Leu Leu Val Gln Leu Leu Thr Pro Cys Ser Gly Leu Cys Ser 
            20                  25                  30          


Pro Leu Gly Ser Leu Tyr Leu Ala Phe Pro Val 
        35                  40              


<210>  1636
<211>  115
<212>  PRT
<213>  Homo Sapiens

<400>  1636

Met Val Gly Glu Asp Ala Asp Leu Pro Cys His Leu Phe Pro Thr Met 
1               5                   10                  15      


Ser Ala Glu Thr Met Glu Leu Lys Trp Val Ser Ser Ser Leu Arg Gln 
            20                  25                  30          


Val Val Asn Val Tyr Ala Asp Gly Lys Glu Val Glu Asp Arg Gln Ser 
        35                  40                  45              


Ala Pro Tyr Arg Gly Arg Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala 
    50                  55                  60                  


Gly Lys Ala Ala Leu Arg Ile His Asn Val Thr Ala Ser Asp Ser Gly 
65                  70                  75                  80  


Lys Tyr Leu Cys Tyr Phe Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu 
                85                  90                  95      


Val Glu Leu Lys Val Ala Ala Leu Gly Ser Asn Leu His Val Glu Val 
            100                 105                 110         


Lys Gly Tyr 
        115 


<210>  1637
<211>  196
<212>  PRT
<213>  Homo Sapiens

<400>  1637

Met Val Gly Glu Asp Ala Asp Leu Pro Cys His Leu Phe Pro Thr Met 
1               5                   10                  15      


Ser Ala Glu Thr Met Glu Leu Lys Trp Val Ser Ser Ser Leu Arg Gln 
            20                  25                  30          


Val Val Asn Val Tyr Ala Asp Gly Lys Glu Val Glu Asp Arg Gln Ser 
        35                  40                  45              


Ala Pro Tyr Arg Gly Arg Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala 
    50                  55                  60                  


Gly Lys Ala Ala Leu Arg Ile His Asn Val Thr Ala Ser Asp Ser Gly 
65                  70                  75                  80  


Lys Tyr Leu Cys Tyr Phe Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu 
                85                  90                  95      


Val Glu Leu Lys Val Ala Ala Leu Gly Ser Asn Leu His Val Glu Val 
            100                 105                 110         


Lys Gly Tyr Glu Asp Gly Gly Ile His Leu Glu Cys Arg Ser Thr Gly 
        115                 120                 125             


Trp Tyr Pro Gln Pro Gln Ile Gln Trp Ser Asn Ala Lys Gly Glu Asn 
    130                 135                 140                 


Ile Pro Ala Val Glu Ala Pro Val Val Ala Asp Gly Val Gly Leu Tyr 
145                 150                 155                 160 


Glu Val Ala Ala Ser Val Ile Met Arg Gly Gly Ser Gly Glu Gly Val 
                165                 170                 175     


Ser Cys Ile Ile Arg Asn Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser 
            180                 185                 190         


Ile Ser Ile Ala 
        195     


<210>  1638
<211>  292
<212>  PRT
<213>  Homo Sapiens

<400>  1638

Met Val Gly Glu Asp Ala Asp Leu Pro Cys His Leu Phe Pro Thr Met 
1               5                   10                  15      


Ser Ala Glu Thr Met Glu Leu Lys Trp Val Ser Ser Ser Leu Arg Gln 
            20                  25                  30          


Val Val Asn Val Tyr Ala Asp Gly Lys Glu Val Glu Asp Arg Gln Ser 
        35                  40                  45              


Ala Pro Tyr Arg Gly Arg Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala 
    50                  55                  60                  


Gly Lys Ala Ala Leu Arg Ile His Asn Val Thr Ala Ser Asp Ser Gly 
65                  70                  75                  80  


Lys Tyr Leu Cys Tyr Phe Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu 
                85                  90                  95      


Val Glu Leu Lys Val Ala Ala Leu Gly Ser Asn Leu His Val Glu Val 
            100                 105                 110         


Lys Gly Tyr Glu Asp Gly Gly Ile His Leu Glu Cys Arg Ser Thr Gly 
        115                 120                 125             


Trp Tyr Pro Gln Pro Gln Ile Gln Trp Ser Asn Ala Lys Gly Glu Asn 
    130                 135                 140                 


Ile Pro Ala Val Glu Ala Pro Val Val Ala Asp Gly Val Gly Leu Tyr 
145                 150                 155                 160 


Glu Val Ala Ala Ser Val Ile Met Arg Gly Gly Ser Gly Glu Gly Val 
                165                 170                 175     


Ser Cys Ile Ile Arg Asn Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser 
            180                 185                 190         


Ile Ser Ile Ala Asp Pro Phe Phe Arg Ser Ala Gln Pro Trp Ile Ala 
        195                 200                 205             


Ala Leu Ala Gly Thr Leu Pro Ile Leu Leu Leu Leu Leu Ala Gly Ala 
    210                 215                 220                 


Ser Tyr Phe Leu Trp Arg Gln Gln Lys Glu Ile Thr Ala Leu Ser Ser 
225                 230                 235                 240 


Glu Ile Glu Ser Glu Gln Glu Met Lys Glu Met Gly Tyr Ala Ala Thr 
                245                 250                 255     


Glu Arg Glu Ile Ser Leu Arg Glu Ser Leu Gln Glu Glu Leu Lys Arg 
            260                 265                 270         


Lys Lys Ile Gln Tyr Leu Thr Arg Gly Glu Glu Ser Ser Ser Asp Thr 
        275                 280                 285             


Asn Lys Ser Ala 
    290         


<210>  1639
<211>  115
<212>  PRT
<213>  Homo Sapiens

<400>  1639

Arg Gly Gly Ser Gly Glu Gly Val Ser Cys Ile Ile Arg Asn Ser Leu 
1               5                   10                  15      


Leu Gly Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala Asp Pro Phe Phe 
            20                  25                  30          


Arg Ser Ala Gln Pro Trp Ile Ala Ala Leu Ala Gly Thr Leu Pro Ile 
        35                  40                  45              


Leu Leu Leu Leu Leu Ala Gly Ala Ser Tyr Phe Leu Trp Arg Gln Gln 
    50                  55                  60                  


Lys Glu Ile Thr Ala Leu Ser Ser Glu Ile Glu Ser Glu Gln Glu Met 
65                  70                  75                  80  


Lys Glu Met Gly Tyr Ala Ala Thr Glu Arg Glu Ile Ser Leu Arg Glu 
                85                  90                  95      


Ser Leu Gln Glu Glu Leu Lys Arg Lys Lys Ile Gln Tyr Leu Thr Arg 
            100                 105                 110         


Glu Trp Leu 
        115 


<210>  1640
<211>  138
<212>  PRT
<213>  Homo Sapiens

<400>  1640

Met Lys Met Ala Ser Ser Leu Ala Phe Leu Leu Leu Asn Phe His Val 
1               5                   10                  15      


Ser Leu Phe Leu Val Gln Leu Leu Thr Pro Cys Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu 
    50                  55                  60                  


Leu Arg Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe 
        115                 120                 125             


Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu 
    130                 135             


<210>  1641
<211>  238
<212>  PRT
<213>  Homo Sapiens

<400>  1641

Met Lys Met Ala Ser Ser Leu Ala Phe Leu Leu Leu Asn Phe His Val 
1               5                   10                  15      


Ser Leu Phe Leu Val Gln Leu Leu Thr Pro Cys Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu 
    50                  55                  60                  


Leu Arg Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe 
        115                 120                 125             


Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala 
    130                 135                 140                 


Ala Leu Gly Ser Asp Leu His Ile Glu Val Lys Gly Tyr Glu Asp Gly 
145                 150                 155                 160 


Gly Ile His Leu Glu Cys Arg Ser Thr Gly Trp Tyr Pro Gln Pro Gln 
                165                 170                 175     


Ile Lys Trp Ser Asp Thr Lys Gly Glu Asn Ile Pro Ala Val Glu Ala 
            180                 185                 190         


Pro Val Val Ala Asp Gly Val Gly Leu Tyr Ala Val Ala Ala Ser Val 
        195                 200                 205             


Ile Met Arg Gly Ser Ser Gly Gly Gly Val Ser Cys Ile Ile Arg Asn 
    210                 215                 220                 


Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala 
225                 230                 235             


<210>  1642
<211>  584
<212>  PRT
<213>  Homo Sapiens

<400>  1642

Met Lys Met Ala Ser Ser Leu Ala Phe Leu Leu Leu Asn Phe His Val 
1               5                   10                  15      


Ser Leu Phe Leu Val Gln Leu Leu Thr Pro Cys Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu 
    50                  55                  60                  


Leu Arg Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe 
        115                 120                 125             


Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala 
    130                 135                 140                 


Ala Leu Gly Ser Asp Leu His Ile Glu Val Lys Gly Tyr Glu Asp Gly 
145                 150                 155                 160 


Gly Ile His Leu Glu Cys Arg Ser Thr Gly Trp Tyr Pro Gln Pro Gln 
                165                 170                 175     


Ile Lys Trp Ser Asp Thr Lys Gly Glu Asn Ile Pro Ala Val Glu Ala 
            180                 185                 190         


Pro Val Val Ala Asp Gly Val Gly Leu Tyr Ala Val Ala Ala Ser Val 
        195                 200                 205             


Ile Met Arg Gly Ser Ser Gly Gly Gly Val Ser Cys Ile Ile Arg Asn 
    210                 215                 220                 


Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala Asp Pro 
225                 230                 235                 240 


Phe Phe Arg Ser Ala Gln Pro Trp Ile Ala Ala Leu Ala Gly Thr Leu 
                245                 250                 255     


Pro Ile Ser Leu Leu Leu Leu Ala Gly Ala Ser Tyr Phe Leu Trp Arg 
            260                 265                 270         


Gln Gln Lys Glu Lys Ile Ala Leu Ser Arg Glu Thr Glu Arg Glu Arg 
        275                 280                 285             


Glu Met Lys Glu Met Gly Tyr Ala Ala Thr Glu Gln Glu Ile Ser Leu 
    290                 295                 300                 


Arg Glu Lys Leu Gln Glu Glu Leu Lys Trp Arg Lys Ile Gln Tyr Met 
305                 310                 315                 320 


Ala Arg Gly Glu Lys Ser Leu Ala Tyr His Glu Trp Lys Met Ala Leu 
                325                 330                 335     


Phe Lys Pro Ala Asp Val Ile Leu Asp Pro Asp Thr Ala Asn Ala Ile 
            340                 345                 350         


Leu Leu Val Ser Glu Asp Gln Arg Ser Val Gln Arg Ala Glu Glu Pro 
        355                 360                 365             


Arg Asp Leu Pro Asp Asn Pro Glu Arg Phe Glu Trp Arg Tyr Cys Val 
    370                 375                 380                 


Leu Gly Cys Glu Asn Phe Thr Ser Gly Arg His Tyr Trp Glu Val Glu 
385                 390                 395                 400 


Val Gly Asp Arg Lys Glu Trp His Ile Gly Val Cys Ser Lys Asn Val 
                405                 410                 415     


Glu Arg Lys Lys Gly Trp Val Lys Met Thr Pro Glu Asn Gly Tyr Trp 
            420                 425                 430         


Thr Met Gly Leu Thr Asp Gly Asn Lys Tyr Arg Ala Leu Thr Glu Pro 
        435                 440                 445             


Arg Thr Asn Leu Lys Leu Pro Glu Pro Pro Arg Lys Val Gly Ile Phe 
    450                 455                 460                 


Leu Asp Tyr Glu Thr Gly Glu Ile Ser Phe Tyr Asn Ala Thr Asp Gly 
465                 470                 475                 480 


Ser His Ile Tyr Thr Phe Pro His Ala Ser Phe Ser Glu Pro Leu Tyr 
                485                 490                 495     


Pro Val Phe Arg Ile Leu Thr Leu Glu Pro Thr Ala Leu Thr Ile Cys 
            500                 505                 510         


Pro Ile Pro Lys Glu Val Glu Ser Ser Pro Asp Pro Asp Leu Val Pro 
        515                 520                 525             


Asp His Ser Leu Glu Thr Pro Leu Thr Pro Gly Leu Ala Asn Glu Ser 
    530                 535                 540                 


Gly Glu Pro Gln Ala Glu Val Thr Ser Leu Leu Leu Pro Ala His Pro 
545                 550                 555                 560 


Gly Ala Glu Val Ser Pro Ser Ala Thr Thr Asn Gln Asn His Lys Leu 
                565                 570                 575     


Gln Ala Arg Thr Glu Ala Leu Tyr 
            580                 


<210>  1643
<211>  127
<212>  PRT
<213>  Homo Sapiens

<400>  1643

Met Lys Met Ala Ser Ser Leu Ala Phe Leu Leu Leu Asn Phe His Val 
1               5                   10                  15      


Ser Leu Phe Leu Val Gln Leu Leu Thr Pro Cys Ser Asp Ala Asp Leu 
            20                  25                  30          


Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu Leu Arg 
        35                  40                  45              


Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala Asp Gly 
    50                  55                  60                  


Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg Thr Ser 
65                  70                  75                  80  


Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg Ile His 
                85                  90                  95      


Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe Gln Asp 
            100                 105                 110         


Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala Ala 
        115                 120                 125         


<210>  1644
<211>  100
<212>  PRT
<213>  Homo Sapiens

<400>  1644

Met Val Gly Glu Asp Ala Asp Leu Pro Cys His Leu Phe Pro Thr Met 
1               5                   10                  15      


Ser Ala Glu Thr Met Glu Leu Arg Trp Val Ser Ser Ser Leu Arg Gln 
            20                  25                  30          


Val Val Asn Val Tyr Ala Asp Gly Lys Glu Val Glu Asp Arg Gln Ser 
        35                  40                  45              


Ala Pro Tyr Arg Gly Arg Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala 
    50                  55                  60                  


Gly Lys Ala Ala Leu Arg Ile His Asn Val Thr Ala Ser Asp Ser Gly 
65                  70                  75                  80  


Lys Tyr Leu Cys Tyr Phe Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu 
                85                  90                  95      


Val Glu Leu Lys 
            100 


<210>  1645
<211>  140
<212>  PRT
<213>  Homo Sapiens

<400>  1645

Met Val Gly Glu Asp Ala Asp Leu Pro Cys His Leu Phe Pro Thr Met 
1               5                   10                  15      


Ser Ala Glu Thr Met Glu Leu Arg Trp Val Ser Ser Ser Leu Arg Gln 
            20                  25                  30          


Val Val Asn Val Tyr Ala Asp Gly Lys Glu Val Glu Asp Arg Gln Ser 
        35                  40                  45              


Ala Pro Tyr Arg Gly Arg Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala 
    50                  55                  60                  


Gly Lys Ala Ala Leu Arg Ile His Asn Val Thr Ala Ser Asp Ser Gly 
65                  70                  75                  80  


Lys Tyr Leu Cys Tyr Phe Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu 
                85                  90                  95      


Val Glu Leu Lys Val Ala Ala Leu Gly Ser Asp Leu His Ile Glu Val 
            100                 105                 110         


Lys Gly Tyr Glu Asp Gly Gly Ile His Leu Glu Cys Arg Ser Thr Gly 
        115                 120                 125             


Trp Tyr Pro Gln Pro Gln Ile Lys Trp Ser Asp Thr 
    130                 135                 140 


<210>  1646
<211>  250
<212>  PRT
<213>  Homo Sapiens

<400>  1646

Met Val Gly Glu Asp Ala Asp Leu Pro Cys His Leu Phe Pro Thr Met 
1               5                   10                  15      


Ser Ala Glu Thr Met Glu Leu Arg Trp Val Ser Ser Ser Leu Arg Gln 
            20                  25                  30          


Val Val Asn Val Tyr Ala Asp Gly Lys Glu Val Glu Asp Arg Gln Ser 
        35                  40                  45              


Ala Pro Tyr Arg Gly Arg Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala 
    50                  55                  60                  


Gly Lys Ala Ala Leu Arg Ile His Asn Val Thr Ala Ser Asp Ser Gly 
65                  70                  75                  80  


Lys Tyr Leu Cys Tyr Phe Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu 
                85                  90                  95      


Val Glu Leu Lys Val Ala Ala Leu Gly Ser Asp Leu His Ile Glu Val 
            100                 105                 110         


Lys Gly Tyr Glu Asp Gly Gly Ile His Leu Glu Cys Arg Ser Thr Gly 
        115                 120                 125             


Trp Tyr Pro Gln Pro Gln Ile Lys Trp Ser Asp Thr Lys Gly Glu Asn 
    130                 135                 140                 


Ile Pro Ala Val Glu Ala Pro Val Val Ala Asp Gly Val Gly Leu Tyr 
145                 150                 155                 160 


Ala Val Ala Ala Ser Val Ile Met Arg Gly Ser Ser Gly Gly Gly Val 
                165                 170                 175     


Ser Cys Ile Ile Arg Asn Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser 
            180                 185                 190         


Ile Ser Ile Ala Asp Pro Phe Phe Arg Ser Ala Gln Pro Trp Ile Ala 
        195                 200                 205             


Ala Leu Ala Gly Thr Leu Pro Ile Ser Leu Leu Leu Leu Ala Gly Ala 
    210                 215                 220                 


Ser Tyr Phe Leu Trp Arg Gln Gln Lys Glu Lys Ile Ala Leu Ser Arg 
225                 230                 235                 240 


Glu Thr Glu Arg Glu Arg Glu Met Lys Glu 
                245                 250 


<210>  1647
<211>  535
<212>  PRT
<213>  Homo Sapiens

<400>  1647

Met Val Gly Glu Asp Ala Asp Leu Pro Cys His Leu Phe Pro Thr Met 
1               5                   10                  15      


Ser Ala Glu Thr Met Glu Leu Arg Trp Val Ser Ser Ser Leu Arg Gln 
            20                  25                  30          


Val Val Asn Val Tyr Ala Asp Gly Lys Glu Val Glu Asp Arg Gln Ser 
        35                  40                  45              


Ala Pro Tyr Arg Gly Arg Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala 
    50                  55                  60                  


Gly Lys Ala Ala Leu Arg Ile His Asn Val Thr Ala Ser Asp Ser Gly 
65                  70                  75                  80  


Lys Tyr Leu Cys Tyr Phe Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu 
                85                  90                  95      


Val Glu Leu Lys Val Ala Ala Leu Gly Ser Asp Leu His Ile Glu Val 
            100                 105                 110         


Lys Gly Tyr Glu Asp Gly Gly Ile His Leu Glu Cys Arg Ser Thr Gly 
        115                 120                 125             


Trp Tyr Pro Gln Pro Gln Ile Lys Trp Ser Asp Thr Lys Gly Glu Asn 
    130                 135                 140                 


Ile Pro Ala Val Glu Ala Pro Val Val Ala Asp Gly Val Gly Leu Tyr 
145                 150                 155                 160 


Ala Val Ala Ala Ser Val Ile Met Arg Gly Ser Ser Gly Gly Gly Val 
                165                 170                 175     


Ser Cys Ile Ile Arg Asn Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser 
            180                 185                 190         


Ile Ser Ile Ala Asp Pro Phe Phe Arg Ser Ala Gln Pro Trp Ile Ala 
        195                 200                 205             


Ala Leu Ala Gly Thr Leu Pro Ile Ser Leu Leu Leu Leu Ala Gly Ala 
    210                 215                 220                 


Ser Tyr Phe Leu Trp Arg Gln Gln Lys Glu Lys Ile Ala Leu Ser Arg 
225                 230                 235                 240 


Glu Thr Glu Arg Glu Arg Glu Met Lys Glu Met Gly Tyr Ala Ala Thr 
                245                 250                 255     


Glu Gln Glu Ile Ser Leu Arg Glu Trp Arg Lys Ile Gln Tyr Met Ala 
            260                 265                 270         


Arg Gly Glu Lys Ser Leu Ala Tyr His Glu Trp Lys Met Ala Leu Phe 
        275                 280                 285             


Lys Pro Ala Asp Val Ile Leu Asp Pro Asp Thr Ala Asn Ala Ile Leu 
    290                 295                 300                 


Leu Val Ser Glu Asp Gln Arg Ser Val Gln Arg Ala Glu Glu Pro Arg 
305                 310                 315                 320 


Asp Leu Pro Asp Asn Pro Glu Arg Phe Glu Trp Arg Tyr Cys Val Leu 
                325                 330                 335     


Gly Cys Glu Asn Phe Thr Ser Gly Arg His Tyr Trp Glu Val Glu Val 
            340                 345                 350         


Gly Asp Arg Lys Glu Trp His Ile Gly Val Cys Ser Lys Asn Val Glu 
        355                 360                 365             


Arg Lys Lys Gly Trp Val Lys Met Thr Pro Glu Asn Gly Tyr Trp Thr 
    370                 375                 380                 


Met Gly Leu Thr Asp Gly Asn Lys Tyr Arg Ala Leu Thr Glu Pro Arg 
385                 390                 395                 400 


Thr Asn Leu Lys Leu Pro Glu Pro Pro Arg Lys Val Gly Ile Phe Leu 
                405                 410                 415     


Asp Tyr Glu Thr Gly Glu Ile Ser Phe Tyr Asn Ala Thr Asp Gly Ser 
            420                 425                 430         


His Ile Tyr Thr Phe Pro His Ala Ser Phe Ser Glu Pro Leu Tyr Pro 
        435                 440                 445             


Val Phe Arg Ile Leu Thr Leu Glu Pro Thr Ala Leu Thr Ile Cys Pro 
    450                 455                 460                 


Ile Pro Lys Glu Val Glu Ser Ser Pro Asp Pro Asp Leu Val Pro Asp 
465                 470                 475                 480 


His Ser Leu Glu Thr Pro Leu Thr Pro Gly Leu Ala Asn Glu Ser Gly 
                485                 490                 495     


Glu Pro Gln Ala Glu Val Thr Ser Leu Leu Leu Pro Ala His Pro Gly 
            500                 505                 510         


Ala Glu Val Ser Pro Ser Ala Thr Thr Asn Gln Asn His Lys Leu Gln 
        515                 520                 525             


Ala Arg Thr Glu Ala Leu Tyr 
    530                 535 


<210>  1648
<211>  210
<212>  PRT
<213>  Homo Sapiens

<400>  1648

Met Val Gly Glu Asp Ala Asp Leu Pro Cys His Leu Phe Pro Thr Met 
1               5                   10                  15      


Ser Ala Glu Thr Met Glu Leu Arg Trp Val Ser Ser Ser Leu Arg Gln 
            20                  25                  30          


Val Val Asn Val Tyr Ala Asp Gly Lys Glu Val Glu Asp Arg Gln Ser 
        35                  40                  45              


Ala Pro Tyr Arg Gly Arg Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala 
    50                  55                  60                  


Gly Lys Ala Ala Leu Arg Ile His Asn Val Thr Ala Ser Asp Ser Gly 
65                  70                  75                  80  


Lys Tyr Leu Cys Tyr Phe Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu 
                85                  90                  95      


Val Glu Leu Lys Val Ala Glu Trp Arg Lys Ile Gln Tyr Met Ala Arg 
            100                 105                 110         


Gly Glu Lys Ser Leu Ala Tyr His Glu Trp Lys Met Ala Leu Phe Lys 
        115                 120                 125             


Pro Ala Asp Val Ile Leu Asp Pro Asp Thr Ala Asn Ala Ile Leu Leu 
    130                 135                 140                 


Val Ser Glu Asp Gln Arg Ser Val Gln Arg Ala Glu Glu Pro Arg Asp 
145                 150                 155                 160 


Leu Pro Asp Asn Pro Glu Arg Phe Glu Trp Arg Tyr Cys Val Leu Gly 
                165                 170                 175     


Cys Glu Asn Phe Thr Ser Gly Arg His Tyr Trp Glu Val Glu Val Gly 
            180                 185                 190         


Asp Arg Lys Glu Trp His Ile Gly Val Cys Ser Lys Asn Val Glu Arg 
        195                 200                 205             


Lys Lys 
    210 


<210>  1649
<211>  270
<212>  PRT
<213>  Homo Sapiens

<400>  1649

Met Trp Leu Leu Val Ser Val Ile Leu Ile Ser Arg Ile Ser Ser Val 
1               5                   10                  15      


Gly Gly Glu Ala Met Phe Cys Asp Phe Pro Lys Ile Asn His Gly Ile 
            20                  25                  30          


Leu Tyr Asp Glu Glu Lys Tyr Lys Pro Phe Ser Gln Val Pro Thr Gly 
        35                  40                  45              


Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys 
    50                  55                  60                  


Ser Phe Trp Thr Arg Ile Thr Cys Ala Glu Glu Gly Trp Ser Pro Thr 
65                  70                  75                  80  


Pro Lys Cys Leu Arg Leu Cys Phe Phe Pro Phe Val Glu Asn Gly His 
                85                  90                  95      


Ser Glu Ser Ser Gly Gln Thr His Leu Glu Gly Asp Thr Val Gln Ile 
            100                 105                 110         


Ile Cys Asn Thr Gly Tyr Arg Leu Gln Asn Asn Glu Asn Asn Ile Ser 
        115                 120                 125             


Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser Thr Ile 
    130                 135                 140                 


Ser Ala Glu Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile 
145                 150                 155                 160 


Thr Ser Phe Leu Leu Ser Val Tyr Ala Pro Gly Ser Ser Val Glu Tyr 
                165                 170                 175     


Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Asn Gln Ile Thr Cys 
            180                 185                 190         


Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu Asp Pro Cys Val 
        195                 200                 205             


Ile Ser Gln Glu Ile Met Glu Lys Tyr Asn Ile Lys Leu Lys Trp Thr 
    210                 215                 220                 


Asn Gln Gln Lys Leu Tyr Ser Arg Thr Gly Asp Ile Val Glu Phe Val 
225                 230                 235                 240 


Cys Lys Ser Gly Tyr His Pro Thr Lys Ser His Ser Phe Arg Ala Met 
                245                 250                 255     


Cys Gln Asn Gly Lys Leu Val Tyr Pro Ser Cys Glu Glu Lys 
            260                 265                 270 


<210>  1650
<211>  81
<212>  PRT
<213>  Homo Sapiens

<400>  1650

Met Arg Leu Leu Val Leu Ser Ser Leu Leu Cys Ile Leu Leu Leu Cys 
1               5                   10                  15      


Phe Ser Ile Phe Ser Thr Glu Gly Lys Arg Arg Pro Ala Lys Ala Trp 
            20                  25                  30          


Ser Gly Arg Arg Thr Arg Leu Cys Cys His Arg Val Pro Ser Pro Asn 
        35                  40                  45              


Ser Thr Asn Leu Lys Gly His His Val Arg Leu Cys Lys Pro Cys Lys 
    50                  55                  60                  


Leu Glu Pro Glu Pro Arg Leu Trp Val Val Pro Gly Ala Leu Pro Gln 
65                  70                  75                  80  


Val 
    


<210>  1651
<211>  121
<212>  PRT
<213>  Homo Sapiens

<400>  1651

Met Ala Ala Ser Gln Cys Leu Cys Cys Ser Lys Phe Leu Phe Gln Arg 
1               5                   10                  15      


Gln Asn Leu Ala Cys Phe Leu Thr Asn Pro His Cys Gly Ser Leu Val 
            20                  25                  30          


Asn Ala Asp Gly His Gly Glu Val Trp Thr Asp Trp Asn Asn Met Ser 
        35                  40                  45              


Lys Phe Phe Gln Tyr Gly Trp Arg Cys Thr Thr Asn Glu Asn Thr Tyr 
    50                  55                  60                  


Ser Asn Arg Thr Leu Met Gly Asn Trp Asn Gln Glu Arg Tyr Asp Leu 
65                  70                  75                  80  


Arg Asn Ile Val Gln Pro Lys Pro Leu Pro Ser Gln Asp Leu Ser Glu 
                85                  90                  95      


Ser Leu Thr Gly Ser Gln Asp Ile Asn Leu Asn Trp Ile Leu Pro Asp 
            100                 105                 110         


Thr Asn Ala Gln Lys Ser Gln Leu Thr 
        115                 120     


<210>  1652
<211>  150
<212>  PRT
<213>  Homo Sapiens

<400>  1652

Met Ala Ala Ser Gln Cys Leu Cys Cys Ser Lys Phe Leu Phe Gln Arg 
1               5                   10                  15      


Gln Asn Leu Ala Cys Phe Leu Thr Asn Pro His Cys Gly Ser Leu Val 
            20                  25                  30          


Asn Ala Asp Gly His Gly Glu Val Trp Thr Asp Trp Asn Asn Met Ser 
        35                  40                  45              


Lys Phe Phe Gln Tyr Gly Trp Arg Cys Thr Thr Asn Glu Asn Thr Tyr 
    50                  55                  60                  


Ser Asn Arg Thr Leu Met Gly Asn Trp Asn Gln Glu Arg Tyr Asp Leu 
65                  70                  75                  80  


Arg Asn Ile Val Gln Pro Lys Pro Leu Pro Ser Gln Phe Gly His Tyr 
                85                  90                  95      


Phe Glu Thr Thr Tyr Asp Thr Ser Tyr Asn Asn Lys Met Pro Leu Ser 
            100                 105                 110         


Thr His Arg Phe Lys Arg Glu Pro His Trp Phe Pro Gly His Gln Pro 
        115                 120                 125             


Glu Leu Asp Pro Pro Arg Tyr Lys Cys Thr Glu Lys Ser Thr Tyr Met 
    130                 135                 140                 


Asn Ser Tyr Ser Lys Pro 
145                 150 


<210>  1653
<211>  142
<212>  PRT
<213>  Homo Sapiens

<400>  1653

Met Glu Gln Pro Ser Lys Asp Phe Cys Asp Ser His Lys Lys Ser Ser 
1               5                   10                  15      


Lys Ser Ser Thr Tyr Ser Ala Ser Ser Tyr Ser Ser Ser Gly Lys Arg 
            20                  25                  30          


Gln Asn Leu Ala Cys Phe Leu Thr Asn Pro His Cys Gly Ser Leu Val 
        35                  40                  45              


Asn Ala Asp Gly His Gly Glu Val Trp Thr Asp Trp Asn Asn Met Ser 
    50                  55                  60                  


Lys Phe Phe Gln Tyr Gly Trp Arg Cys Thr Thr Asn Glu Asn Thr Tyr 
65                  70                  75                  80  


Ser Asn Arg Thr Leu Met Gly Asn Trp Asn Gln Glu Arg Tyr Asp Leu 
                85                  90                  95      


Arg Asn Ile Val Gln Pro Lys Pro Leu Pro Ser Gln Phe Gly His Tyr 
            100                 105                 110         


Phe Glu Thr Thr Tyr Asp Thr Ser Tyr Asn Asn Lys Met Pro Leu Ser 
        115                 120                 125             


Thr His Arg Phe Lys Arg Glu Pro His Trp Phe Pro Gly His 
    130                 135                 140         


<210>  1654
<211>  104
<212>  PRT
<213>  Homo Sapiens

<400>  1654

Met Ser Lys Phe Phe Gln Tyr Gly Trp Arg Cys Thr Thr Asn Glu Asn 
1               5                   10                  15      


Thr Tyr Ser Asn Arg Thr Leu Met Gly Asn Trp Asn Gln Glu Arg Tyr 
            20                  25                  30          


Asp Leu Arg Asn Ile Val Gln Pro Lys Pro Leu Pro Ser Gln Phe Gly 
        35                  40                  45              


His Tyr Phe Glu Thr Thr Tyr Asp Thr Ser Tyr Asn Asn Lys Met Pro 
    50                  55                  60                  


Leu Ser Thr His Arg Phe Lys Arg Glu Pro His Trp Phe Pro Gly His 
65                  70                  75                  80  


Gln Pro Glu Leu Asp Pro Pro Arg Tyr Lys Cys Thr Glu Lys Ser Thr 
                85                  90                  95      


Tyr Met Asn Ser Tyr Ser Lys Pro 
            100                 


<210>  1655
<211>  190
<212>  PRT
<213>  Homo Sapiens

<400>  1655

Met Val Ile Trp Val Ile Leu Ser Leu Leu Gly Glu Leu Gly Lys Pro 
1               5                   10                  15      


Gly Leu Leu Thr Ser Leu Lys Asn Met Glu Gln Pro Ser Lys Asp Phe 
            20                  25                  30          


Cys Asp Ser His Lys Lys Ser Ser Lys Ser Ser Thr Tyr Ser Ala Ser 
        35                  40                  45              


Ser Tyr Ser Ser Ser Gly Lys Arg Gln Asn Leu Ala Cys Phe Leu Thr 
    50                  55                  60                  


Asn Pro His Cys Gly Ser Leu Val Asn Ala Asp Gly His Gly Glu Val 
65                  70                  75                  80  


Trp Thr Asp Trp Asn Asn Met Ser Lys Phe Phe Gln Tyr Gly Trp Arg 
                85                  90                  95      


Cys Thr Thr Asn Glu Asn Thr Tyr Ser Asn Arg Thr Leu Met Gly Asn 
            100                 105                 110         


Trp Asn Gln Glu Arg Tyr Asp Leu Arg Asn Ile Val Gln Pro Lys Pro 
        115                 120                 125             


Leu Pro Ser Gln Phe Gly His Tyr Phe Glu Thr Thr Tyr Asp Thr Ser 
    130                 135                 140                 


Tyr Asn Asn Lys Met Pro Leu Ser Thr His Arg Phe Lys Arg Glu Pro 
145                 150                 155                 160 


His Trp Phe Pro Gly His Gln Pro Glu Leu Asp Pro Pro Arg Tyr Lys 
                165                 170                 175     


Cys Thr Glu Lys Ser Thr Tyr Met Asn Ser Tyr Ser Lys Pro 
            180                 185                 190 


<210>  1656
<211>  25
<212>  PRT
<213>  Homo Sapiens

<400>  1656

Met Trp Thr Ala Leu Val Leu Ile Trp Ile Phe Ser Leu Ser Leu Ser 
1               5                   10                  15      


Glu Ser His Ala Ala Ser Asn Asp Pro 
            20                  25  


<210>  1657
<211>  114
<212>  PRT
<213>  Homo Sapiens

<400>  1657

Met Trp Thr Ala Leu Val Leu Ile Trp Ile Phe Ser Leu Ser Leu Ser 
1               5                   10                  15      


Glu Ser His Ala Ala Ser Asn Asp Pro Arg Asn Phe Val Pro Asn Lys 
            20                  25                  30          


Met Trp Lys Gly Leu Val Lys Arg Asn Ala Ser Val Glu Thr Val Asp 
        35                  40                  45              


Asn Lys Thr Ser Glu Asp Val Thr Met Ala Ala Ala Ser Pro Val Thr 
    50                  55                  60                  


Leu Thr Lys Gly Thr Ser Ala Ala His Leu Asn Ser Met Glu Val Thr 
65                  70                  75                  80  


Thr Glu Asp Thr Ser Arg Thr Asp Ala Tyr Glu Ser Tyr Lys Lys Lys 
                85                  90                  95      


Asp Tyr Thr Gln Val Asp Tyr Leu Ile Asn Gly Met Tyr Ala Asp Ser 
            100                 105                 110         


Glu Met 
        


<210>  1658
<211>  449
<212>  PRT
<213>  Homo Sapiens

<400>  1658

Met Trp Thr Ala Leu Val Leu Ile Trp Ile Phe Ser Leu Ser Leu Ser 
1               5                   10                  15      


Glu Ser His Ala Ala Ser Asn Asp Pro Arg Asn Phe Val Pro Asn Lys 
            20                  25                  30          


Met Trp Lys Gly Leu Val Lys Arg Asn Ala Ser Val Glu Thr Val Asp 
        35                  40                  45              


Asn Lys Thr Ser Glu Asp Val Thr Met Ala Ala Ala Ser Pro Val Thr 
    50                  55                  60                  


Leu Thr Lys Gly Thr Ser Ala Ala His Leu Asn Ser Met Glu Val Thr 
65                  70                  75                  80  


Thr Glu Asp Thr Ser Arg Thr Asp Val Ser Glu Pro Ala Thr Ser Gly 
                85                  90                  95      


Gly Ala Ala Asp Gly Val Thr Ser Ile Ala Pro Thr Ala Val Ala Ser 
            100                 105                 110         


Ser Thr Thr Ala Ala Ser Ile Thr Thr Ala Ala Ser Ser Met Thr Val 
        115                 120                 125             


Ala Ser Ser Ala Pro Thr Thr Ala Ala Ser Ser Thr Thr Val Ala Ser 
    130                 135                 140                 


Ile Ala Pro Thr Thr Ala Ala Ser Ser Met Thr Ala Ala Ser Ser Thr 
145                 150                 155                 160 


Pro Met Thr Leu Ala Leu Pro Ala Pro Thr Ser Thr Ser Thr Gly Arg 
                165                 170                 175     


Thr Pro Ser Thr Thr Ala Thr Gly His Pro Ser Leu Ser Thr Ala Leu 
            180                 185                 190         


Ala Gln Val Pro Lys Ser Ser Ala Leu Pro Arg Thr Ala Thr Leu Ala 
        195                 200                 205             


Thr Leu Ala Thr Arg Ala Gln Thr Val Ala Thr Thr Ala Asn Thr Ser 
    210                 215                 220                 


Ser Pro Met Ser Thr Arg Pro Ser Pro Ser Lys His Met Pro Ser Asp 
225                 230                 235                 240 


Thr Ala Ala Ser Pro Val Pro Pro Met Arg Pro Gln Ala Gln Gly Pro 
                245                 250                 255     


Ile Ser Gln Val Ser Val Asp Gln Pro Val Val Asn Thr Thr Asn Lys 
            260                 265                 270         


Ser Thr Pro Met Pro Ser Asn Thr Thr Pro Glu Pro Ala Pro Thr Pro 
        275                 280                 285             


Thr Val Val Thr Thr Thr Lys Ala Gln Ala Arg Glu Pro Thr Ala Ser 
    290                 295                 300                 


Pro Val Pro Val Pro His Thr Ser Pro Ile Pro Glu Met Glu Ala Met 
305                 310                 315                 320 


Ser Pro Thr Thr Gln Pro Ser Pro Met Pro Tyr Thr Gln Arg Ala Ala 
                325                 330                 335     


Gly Pro Gly Thr Ser Gln Ala Pro Glu Gln Val Glu Thr Glu Ala Thr 
            340                 345                 350         


Pro Gly Thr Asp Ser Thr Gly Pro Thr Pro Arg Ser Ser Gly Gly Thr 
        355                 360                 365             


Lys Met Pro Ala Thr Asp Ser Cys Gln Pro Ser Thr Gln Gly Gln Tyr 
    370                 375                 380                 


Met Val Val Thr Thr Glu Pro Leu Thr Gln Ala Val Val Asp Lys Thr 
385                 390                 395                 400 


Leu Leu Leu Val Val Leu Leu Leu Gly Val Thr Leu Phe Ile Thr Val 
                405                 410                 415     


Leu Val Leu Phe Ala Leu Gln Ala Tyr Glu Ser Tyr Lys Lys Lys Asp 
            420                 425                 430         


Tyr Thr Gln Val Asp Tyr Leu Ile Asn Gly Met Tyr Ala Asp Ser Glu 
        435                 440                 445             


Met 
    


<210>  1659
<211>  145
<212>  PRT
<213>  Homo Sapiens

<400>  1659

Met Leu Thr Arg Leu Val Leu Ser Ala His Leu Ser Ser Thr Thr Ser 
1               5                   10                  15      


Pro Pro Trp Thr His Ala Ala Ile Ser Trp Glu Leu Asp Asn Val Leu 
            20                  25                  30          


Met Pro Ser Pro Arg Ile Trp Pro Gln Val Thr Pro Thr Gly Arg Ser 
        35                  40                  45              


Ala Ser Val Arg Ser Glu Gly Asn Thr Ser Ser Leu Trp Asn Phe Ser 
    50                  55                  60                  


Ala Gly Gln Asp Val His Ala Ile Val Thr Arg Thr Cys Glu Ser Val 
65                  70                  75                  80  


Leu Ser Ser Ala Val Tyr Thr His Gly Cys Gly Cys Val Arg Ser Ala 
                85                  90                  95      


Thr Asn Ile Thr Cys Gln Ser Ser Gly Gln Gln Arg Gln Ala Ala Arg 
            100                 105                 110         


Gln Glu Glu Glu Asn Ser Ile Cys Lys Ala His Asp Ser Arg Glu Gly 
        115                 120                 125             


Arg Leu Gly Tyr Pro Leu Ser Ala His Gln Pro Gly Ser Gly Gly Pro 
    130                 135                 140                 


Asn 
145 


<210>  1660
<211>  145
<212>  PRT
<213>  Homo Sapiens

<400>  1660

Met Leu Thr Arg Leu Val Leu Ser Ala His Leu Ser Ser Thr Thr Ser 
1               5                   10                  15      


Pro Pro Trp Thr His Ala Ala Ile Ser Trp Glu Leu Asp Asn Val Leu 
            20                  25                  30          


Met Pro Ser Pro Arg Ile Trp Pro Gln Val Thr Pro Thr Gly Arg Ser 
        35                  40                  45              


Ala Ser Val Arg Ser Glu Gly Asn Thr Ser Ser Leu Trp Asn Phe Ser 
    50                  55                  60                  


Ala Gly Gln Asp Val His Ala Ile Val Thr Arg Thr Cys Glu Ser Val 
65                  70                  75                  80  


Leu Ser Ser Ala Val Tyr Thr His Gly Cys Gly Cys Val Arg Ser Ala 
                85                  90                  95      


Thr Asn Ile Thr Cys Gln Ser Ser Gly Gln Gln Arg Gln Ala Ala Arg 
            100                 105                 110         


Gln Glu Glu Glu Asn Ser Ile Cys Lys Ala His Asp Ser Arg Glu Gly 
        115                 120                 125             


Arg Leu Gly Tyr Pro Leu Ser Ala His Gln Pro Gly Ser Gly Gly Pro 
    130                 135                 140                 


Asn 
145 


<210>  1661
<211>  98
<212>  PRT
<213>  Homo Sapiens

<400>  1661

Met Val Leu Ala Met Leu Gly Ala Leu His Pro Arg Ala Gly Leu Ser 
1               5                   10                  15      


Leu Phe Leu His Leu Ile Leu Ala Val Ala Leu Leu Arg Ser Gln Pro 
            20                  25                  30          


Leu Arg Ser Gln Arg Ser Val Pro Glu Ala Phe Ser Ala Pro Leu Glu 
        35                  40                  45              


Leu Ser Gln Pro Leu Ser Gly Leu Val Asp Asp Tyr Gly Ile Leu Pro 
    50                  55                  60                  


Lys His Pro Arg Pro Arg Gly Pro Arg Pro Leu Leu Ser Arg Ala Gln 
65                  70                  75                  80  


Gln Arg Lys Arg Asp Gly Pro Asp Leu Ala Glu Tyr Tyr Tyr Asp Ala 
                85                  90                  95      


His Leu 
        


<210>  1662
<211>  376
<212>  PRT
<213>  Homo Sapiens

<400>  1662

Met Gly His Gln Phe Leu Arg Gly Leu Leu Thr Leu Leu Leu Pro Pro 
1               5                   10                  15      


Pro Pro Leu Tyr Thr Arg His Arg Met Leu Gly Pro Glu Ser Val Pro 
            20                  25                  30          


Pro Pro Lys Arg Ser Arg Ser Lys Leu Met Ala Pro Pro Arg Ile Gly 
        35                  40                  45              


Thr His Asn Gly Thr Phe His Cys Asp Glu Ala Leu Ala Cys Ala Leu 
    50                  55                  60                  


Leu Arg Leu Leu Pro Glu Tyr Arg Asp Ala Glu Ile Val Arg Thr Arg 
65                  70                  75                  80  


Asp Pro Glu Lys Leu Ala Ser Cys Asp Ile Val Val Asp Val Gly Gly 
                85                  90                  95      


Glu Tyr Asp Pro Arg Arg His Arg Tyr Asp His His Gln Arg Ser Phe 
            100                 105                 110         


Thr Glu Thr Met Ser Ser Leu Ser Pro Gly Lys Pro Trp Gln Thr Lys 
        115                 120                 125             


Leu Ser Ser Ala Gly Leu Ile Tyr Leu His Phe Gly His Lys Leu Leu 
    130                 135                 140                 


Ala Gln Leu Leu Gly Thr Ser Glu Glu Asp Ser Met Val Gly Thr Leu 
145                 150                 155                 160 


Tyr Asp Lys Met Tyr Glu Asn Phe Val Glu Glu Val Asp Ala Val Asp 
                165                 170                 175     


Asn Gly Ile Ser Gln Trp Ala Glu Gly Glu Pro Arg Tyr Ala Leu Thr 
            180                 185                 190         


Thr Thr Leu Ser Ala Arg Val Ala Arg Leu Asn Pro Thr Trp Asn His 
        195                 200                 205             


Pro Asp Gln Asp Thr Glu Ala Gly Phe Lys Arg Ala Met Asp Leu Val 
    210                 215                 220                 


Gln Glu Glu Phe Leu Gln Arg Leu Asp Phe Tyr Gln His Ser Trp Leu 
225                 230                 235                 240 


Pro Ala Arg Ala Leu Val Glu Glu Ala Leu Ala Gln Arg Phe Gln Val 
                245                 250                 255     


Asp Pro Ser Gly Glu Ile Val Glu Leu Ala Lys Gly Ala Cys Pro Trp 
            260                 265                 270         


Lys Glu His Leu Tyr His Leu Glu Ser Gly Leu Ser Pro Pro Val Ala 
        275                 280                 285             


Ile Phe Phe Val Ile Tyr Thr Asp Gln Ala Gly Gln Trp Arg Ile Gln 
    290                 295                 300                 


Cys Val Pro Lys Glu Pro His Ser Phe Gln Ser Arg Leu Pro Leu Pro 
305                 310                 315                 320 


Glu Pro Trp Arg Gly Leu Arg Asp Glu Ala Leu Asp Gln Val Ser Gly 
                325                 330                 335     


Ile Pro Gly Cys Ile Phe Val His Ala Ser Gly Phe Thr Gly Gly His 
            340                 345                 350         


His Thr Arg Glu Gly Ala Leu Ser Met Ala Arg Ala Thr Leu Ala Gln 
        355                 360                 365             


Arg Ser Tyr Leu Pro Gln Ile Ser 
    370                 375     


<210>  1663
<211>  301
<212>  PRT
<213>  Homo Sapiens

<400>  1663

Met Leu Gly Pro Glu Ser Val Pro Pro Pro Lys Arg Ser Arg Ser Lys 
1               5                   10                  15      


Leu Met Ala Pro Pro Arg Ile Gly Thr His Asn Gly Thr Phe His Cys 
            20                  25                  30          


Asp Glu Ala Leu Ala Cys Ala Leu Leu Arg Leu Leu Pro Glu Tyr Arg 
        35                  40                  45              


Asp Ala Glu Ile Val Arg Thr Arg Asp Pro Glu Lys Leu Ala Ser Cys 
    50                  55                  60                  


Asp Ile Val Val Asp Val Gly Gly Glu Tyr Asp Pro Arg Arg His Arg 
65                  70                  75                  80  


Tyr Asp His His Gln Arg Ser Phe Thr Glu Thr Met Ser Ser Leu Ser 
                85                  90                  95      


Pro Gly Lys Pro Trp Gln Thr Lys Leu Ser Ser Ala Gly Leu Ile Tyr 
            100                 105                 110         


Leu His Phe Gly His Lys Leu Leu Ala Gln Leu Leu Gly Thr Ser Glu 
        115                 120                 125             


Glu Asp Ser Met Val Gly Thr Leu Tyr Asp Lys Ala Gly Phe Lys Arg 
    130                 135                 140                 


Ala Met Asp Leu Val Gln Glu Glu Phe Leu Gln Arg Leu Asp Phe Tyr 
145                 150                 155                 160 


Gln His Ser Trp Leu Pro Ala Arg Ala Leu Val Glu Glu Ala Leu Ala 
                165                 170                 175     


Gln Arg Phe Gln Val Asp Pro Ser Gly Glu Ile Val Glu Leu Ala Lys 
            180                 185                 190         


Gly Ala Cys Pro Trp Lys Glu His Leu Tyr His Leu Glu Ser Gly Leu 
        195                 200                 205             


Ser Pro Pro Val Ala Ile Phe Phe Val Ile Tyr Thr Asp Gln Ala Gly 
    210                 215                 220                 


Gln Trp Arg Ile Gln Cys Val Pro Lys Glu Pro His Ser Phe Gln Ser 
225                 230                 235                 240 


Arg Leu Pro Leu Pro Glu Pro Trp Arg Gly Leu Arg Asp Glu Ala Leu 
                245                 250                 255     


Asp Gln Val Ser Gly Ile Pro Gly Cys Ile Phe Val His Ala Ser Gly 
            260                 265                 270         


Phe Thr Gly Gly His His Thr Arg Glu Gly Ala Leu Ser Met Ala Arg 
        275                 280                 285             


Ala Thr Leu Ala Gln Arg Ser Tyr Leu Pro Gln Ile Ser 
    290                 295                 300     


<210>  1664
<211>  213
<212>  PRT
<213>  Homo Sapiens

<400>  1664

Met Tyr Glu Asn Phe Val Glu Glu Val Asp Ala Val Asp Asn Gly Ile 
1               5                   10                  15      


Ser Gln Trp Ala Glu Gly Glu Pro Arg Tyr Ala Leu Thr Thr Thr Leu 
            20                  25                  30          


Ser Ala Arg Val Ala Arg Leu Asn Pro Thr Trp Asn His Pro Asp Gln 
        35                  40                  45              


Asp Thr Glu Ala Gly Phe Lys Arg Ala Met Asp Leu Val Gln Glu Glu 
    50                  55                  60                  


Phe Leu Gln Arg Leu Asp Phe Tyr Gln His Ser Trp Leu Pro Ala Arg 
65                  70                  75                  80  


Ala Leu Val Glu Glu Ala Leu Ala Gln Arg Phe Gln Val Asp Pro Ser 
                85                  90                  95      


Gly Glu Ile Val Glu Leu Ala Lys Gly Ala Cys Pro Trp Lys Glu His 
            100                 105                 110         


Leu Tyr His Leu Glu Ser Gly Leu Ser Pro Pro Val Ala Ile Phe Phe 
        115                 120                 125             


Val Ile Tyr Thr Asp Gln Ala Gly Gln Trp Arg Ile Gln Cys Val Pro 
    130                 135                 140                 


Lys Glu Pro His Ser Phe Gln Ser Arg Leu Pro Leu Pro Glu Pro Trp 
145                 150                 155                 160 


Arg Gly Leu Arg Asp Glu Ala Leu Asp Gln Val Ser Gly Ile Pro Gly 
                165                 170                 175     


Cys Ile Phe Val His Ala Ser Gly Phe Thr Gly Gly His His Thr Arg 
            180                 185                 190         


Glu Gly Ala Leu Ser Met Ala Arg Ala Thr Leu Ala Gln Arg Ser Tyr 
        195                 200                 205             


Leu Pro Gln Ile Ser 
    210             


<210>  1665
<211>  130
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1665

Xaa Met Val Gly Thr Leu Tyr Asp Lys Val Asp Pro Ser Gly Glu Ile 
1               5                   10                  15      


Val Glu Leu Ala Lys Gly Ala Cys Pro Trp Lys Glu His Leu Tyr His 
            20                  25                  30          


Leu Glu Ser Gly Leu Ser Pro Pro Val Ala Ile Phe Phe Val Ile Tyr 
        35                  40                  45              


Thr Asp Gln Ala Gly Gln Trp Arg Ile Gln Cys Val Pro Lys Glu Pro 
    50                  55                  60                  


His Ser Phe Gln Ser Arg Leu Pro Leu Pro Glu Pro Trp Arg Gly Leu 
65                  70                  75                  80  


Arg Asp Glu Ala Leu Asp Gln Val Ser Gly Ile Pro Gly Cys Ile Phe 
                85                  90                  95      


Val His Ala Ser Gly Phe Thr Gly Gly His His Thr Arg Glu Gly Ala 
            100                 105                 110         


Leu Ser Met Ala Arg Ala Thr Leu Ala Gln Arg Ser Tyr Leu Pro Gln 
        115                 120                 125             


Ile Ser 
    130 


<210>  1666
<211>  46
<212>  PRT
<213>  Homo Sapiens

<400>  1666

Met Ala Val Glu Asp His Phe Glu Leu Cys Leu Ala Lys Cys Arg Thr 
1               5                   10                  15      


Ser Ser Gln Ser Val Gln His Glu Asn Thr Tyr Arg Asp Pro Ile Ala 
            20                  25                  30          


Lys Tyr Cys Tyr Gly Glu Ser Pro Pro Glu Leu Phe Pro Ala 
        35                  40                  45      


<210>  1667
<211>  47
<212>  PRT
<213>  Homo Sapiens

<400>  1667

Met Val Asn Leu Ala Ala Met Val Trp Arg Arg Leu Leu Arg Lys Arg 
1               5                   10                  15      


Trp Val Leu Ala Leu Val Phe Gly Leu Ser Leu Val Tyr Phe Leu Ser 
            20                  25                  30          


Ser Thr Phe Lys Gln Ala Thr Phe Ala Arg Gly Arg Ile Cys Trp 
        35                  40                  45          


<210>  1668
<211>  205
<212>  PRT
<213>  Homo Sapiens

<400>  1668

Met Val Asn Leu Ala Ala Met Val Trp Arg Arg Leu Leu Arg Lys Arg 
1               5                   10                  15      


Trp Val Leu Ala Leu Val Phe Gly Leu Ser Leu Val Tyr Phe Leu Ser 
            20                  25                  30          


Ser Thr Phe Lys Gln Glu Glu Arg Ala Val Arg Asp Arg Asn Leu Leu 
        35                  40                  45              


Gln Val His Asp His Asn Gln Pro Ile Pro Trp Lys Val Gln Phe Asn 
    50                  55                  60                  


Leu Gly Asn Ser Ser Arg Pro Ser Asn Gln Cys Arg Asn Ser Ile Gln 
65                  70                  75                  80  


Gly Lys His Leu Ile Thr Asp Glu Leu Gly Tyr Val Cys Glu Arg Lys 
                85                  90                  95      


Asp Leu Leu Val Asn Gly Cys Cys Asn Val Asn Val Pro Ser Thr Lys 
            100                 105                 110         


Gln Tyr Cys Cys Asp Gly Cys Trp Pro Asn Gly Cys Cys Ser Ala Tyr 
        115                 120                 125             


Glu Tyr Cys Val Ser Cys Cys Leu Gln Pro Asn Lys Gln Leu Leu Leu 
    130                 135                 140                 


Glu Arg Phe Leu Asn Arg Ala Ala Val Ala Phe Gln Asn Leu Phe Met 
145                 150                 155                 160 


Ala Val Glu Asp His Phe Glu Leu Cys Leu Ala Lys Cys Arg Thr Ser 
                165                 170                 175     


Ser Gln Ser Val Gln His Glu Asn Thr Tyr Arg Asp Pro Ile Ala Lys 
            180                 185                 190         


Tyr Cys Tyr Gly Glu Ser Pro Pro Glu Leu Phe Pro Ala 
        195                 200                 205 


<210>  1669
<211>  43
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1669

Xaa Phe Gly Leu Ser Leu Val Tyr Phe Leu Ser Ser Thr Phe Lys Gln 
1               5                   10                  15      


Ser Val Gln His Glu Asn Thr Tyr Arg Asp Pro Ile Ala Lys Tyr Cys 
            20                  25                  30          


Tyr Gly Glu Ser Pro Pro Glu Leu Phe Pro Ala 
        35                  40              


<210>  1670
<211>  53
<212>  PRT
<213>  Homo Sapiens

<400>  1670

Met Pro Ala Gly Val Pro Met Ser Thr Tyr Leu Lys Met Phe Ala Ala 
1               5                   10                  15      


Ser Leu Leu Ala Met Cys Ala Gly Ala Glu Val Val His Arg Tyr Tyr 
            20                  25                  30          


Arg Pro Asp Leu Met Arg Asn Arg Leu Arg Arg Val Lys Leu Ile Ser 
        35                  40                  45              


Gln Ser His Ile Ala 
    50              


<210>  1671
<211>  53
<212>  PRT
<213>  Homo Sapiens

<400>  1671

Met Pro Ala Gly Val Pro Met Ser Thr Tyr Leu Lys Met Phe Ala Ala 
1               5                   10                  15      


Ser Leu Leu Ala Met Cys Ala Gly Ala Glu Val Val His Arg Tyr Tyr 
            20                  25                  30          


Arg Pro Asp Leu Met Arg Asn Arg Leu Arg Arg Val Lys Leu Ile Ser 
        35                  40                  45              


Gln Ser His Ile Ala 
    50              


<210>  1672
<211>  59
<212>  PRT
<213>  Homo Sapiens

<400>  1672

Met Pro Ala Gly Val Pro Met Ser Thr Tyr Leu Lys Met Phe Ala Ala 
1               5                   10                  15      


Ser Leu Leu Ala Met Cys Ala Gly Ala Glu Val Val His Arg Tyr Tyr 
            20                  25                  30          


Arg Pro Asp Leu Gln Asn Trp Ile Thr Ser Leu Ser Val Gly Glu Leu 
        35                  40                  45              


Glu Gly Leu Gly Arg Val Glu Gln Arg Arg Pro 
    50                  55                  


<210>  1673
<211>  59
<212>  PRT
<213>  Homo Sapiens

<400>  1673

Met Pro Ala Gly Val Pro Met Ser Thr Tyr Leu Lys Met Phe Ala Ala 
1               5                   10                  15      


Ser Leu Leu Ala Met Cys Ala Gly Ala Glu Val Val His Arg Tyr Tyr 
            20                  25                  30          


Arg Pro Asp Leu Gln Asn Trp Ile Thr Ser Leu Ser Val Gly Glu Leu 
        35                  40                  45              


Glu Gly Leu Gly Arg Val Glu Gln Arg Arg Pro 
    50                  55                  


<210>  1674
<211>  71
<212>  PRT
<213>  Homo Sapiens

<400>  1674

Met Pro Ala Gly Val Pro Met Ser Thr Tyr Leu Lys Met Phe Ala Ala 
1               5                   10                  15      


Ser Leu Leu Ala Met Cys Ala Gly Ala Glu Val Val His Arg Tyr Tyr 
            20                  25                  30          


Arg Pro Asp Leu Thr Ile Pro Glu Ile Pro Pro Lys Arg Gly Glu Leu 
        35                  40                  45              


Lys Thr Glu Leu Leu Gly Leu Lys Glu Arg Lys His Lys Pro Gln Val 
    50                  55                  60                  


Ser Gln Gln Glu Glu Leu Lys 
65                  70      


<210>  1675
<211>  71
<212>  PRT
<213>  Homo Sapiens

<400>  1675

Met Pro Ala Gly Val Pro Met Ser Thr Tyr Leu Lys Met Phe Ala Ala 
1               5                   10                  15      


Ser Leu Leu Ala Met Cys Ala Gly Ala Glu Val Val His Arg Tyr Tyr 
            20                  25                  30          


Arg Pro Asp Leu Thr Ile Pro Glu Ile Pro Pro Lys Arg Gly Glu Leu 
        35                  40                  45              


Lys Thr Glu Leu Leu Gly Leu Lys Glu Arg Lys His Lys Pro Gln Val 
    50                  55                  60                  


Ser Gln Gln Glu Glu Leu Lys 
65                  70      


<210>  1676
<211>  71
<212>  PRT
<213>  Homo Sapiens

<400>  1676

Met Pro Ala Gly Val Pro Met Ser Thr Tyr Leu Lys Met Phe Ala Ala 
1               5                   10                  15      


Ser Leu Leu Ala Met Cys Ala Gly Ala Glu Val Val His Arg Tyr Tyr 
            20                  25                  30          


Arg Pro Asp Leu Thr Ile Pro Glu Ile Pro Pro Lys Arg Gly Glu Leu 
        35                  40                  45              


Lys Thr Glu Leu Leu Gly Leu Lys Glu Arg Lys His Lys Pro Gln Val 
    50                  55                  60                  


Ser Gln Gln Glu Glu Leu Lys 
65                  70      


<210>  1677
<211>  71
<212>  PRT
<213>  Homo Sapiens

<400>  1677

Met Pro Ala Gly Val Pro Met Ser Thr Tyr Leu Lys Met Phe Ala Ala 
1               5                   10                  15      


Ser Leu Leu Ala Met Cys Ala Gly Ala Glu Val Val His Arg Tyr Tyr 
            20                  25                  30          


Arg Pro Asp Leu Thr Ile Pro Glu Ile Pro Pro Lys Arg Gly Glu Leu 
        35                  40                  45              


Lys Thr Glu Leu Leu Gly Leu Lys Glu Arg Lys His Lys Pro Gln Val 
    50                  55                  60                  


Ser Gln Gln Glu Glu Leu Lys 
65                  70      


<210>  1678
<211>  37
<212>  PRT
<213>  Homo Sapiens

<400>  1678

Met Pro Ala Gly Val Pro Met Ser Thr Tyr Leu Lys Met Phe Ala Ala 
1               5                   10                  15      


Ser Leu Leu Ala Met Cys Ala Gly Ala Glu Val Val His Arg Tyr Tyr 
            20                  25                  30          


Arg Pro Asp Leu Val 
        35          


<210>  1679
<211>  46
<212>  PRT
<213>  Homo Sapiens

<400>  1679

Met Pro Ala Gly Val Pro Met Ser Thr Tyr Leu Lys Met Phe Ala Ala 
1               5                   10                  15      


Ser Leu Leu Ala Met Cys Ala Gly Ala Glu Val Val His Arg Tyr Tyr 
            20                  25                  30          


Arg Pro Asp Leu Val Ser Ala Gly Gly Leu Leu Phe Tyr Phe 
        35                  40                  45      


<210>  1680
<211>  135
<212>  PRT
<213>  Homo Sapiens

<400>  1680

Phe Phe Leu His Gln Gln Gly Thr Phe Glu Lys Glu Ile Gly Lys Ile 
1               5                   10                  15      


Ile Pro Phe Thr Ile Ala Phe Lys Arg Ala Glu Ala Val Glu Pro Asp 
            20                  25                  30          


Gly Cys Val Gln Ser Trp Arg Cys Cys Leu Pro Cys Asp Leu Gly Gln 
        35                  40                  45              


Ala Ser Arg Phe Ile His Thr Thr Val Cys Ser Ala Ile Arg Trp Arg 
    50                  55                  60                  


Ser Cys Lys Gly Glu Arg Asn Phe Ala Glu Arg His Ile Leu Pro Ala 
65                  70                  75                  80  


Glu Leu Glu Glu Gln Ser Asn His Ala Gly Met Gly Pro Ile Leu Pro 
                85                  90                  95      


Ala Met Pro Ser Val Asp Gly Asn His Phe Gln His Pro Ala Gly Asp 
            100                 105                 110         


Cys His Pro Tyr Gly Ile Leu Cys Leu Gln Ala His Ser Ala Ser Val 
        115                 120                 125             


Thr Ala Arg Gln Val Leu Gln 
    130                 135 


<210>  1681
<211>  135
<212>  PRT
<213>  Homo Sapiens

<400>  1681

Met Phe Gln Asn Leu Gln Gly Thr Phe Glu Lys Glu Ile Gly Lys Ile 
1               5                   10                  15      


Ile Pro Phe Thr Ile Ala Phe Lys Arg Ala Glu Ala Val Glu Pro Asp 
            20                  25                  30          


Gly Cys Val Gln Ser Trp Arg Cys Cys Leu Pro Cys Asp Leu Gly Gln 
        35                  40                  45              


Ala Ser Arg Phe Ile His Thr Thr Val Cys Ser Ala Ile Arg Trp Arg 
    50                  55                  60                  


Ser Cys Lys Gly Glu Arg Asn Phe Ala Glu Arg His Ile Leu Pro Ala 
65                  70                  75                  80  


Glu Leu Glu Glu Gln Ser Asn His Ala Gly Met Gly Pro Ile Leu Pro 
                85                  90                  95      


Ala Met Pro Ser Val Asp Gly Asn His Phe Gln His Pro Ala Gly Asp 
            100                 105                 110         


Cys His Pro Tyr Gly Ile Leu Cys Leu Gln Ala His Ser Ala Ser Val 
        115                 120                 125             


Thr Ala Arg Gln Val Leu Gln 
    130                 135 


<210>  1682
<211>  107
<212>  PRT
<213>  Homo Sapiens

<400>  1682

Met Leu Glu Arg Glu Asn Glu Ser His Gly Ser Lys Ser Cys Ser Arg 
1               5                   10                  15      


Ala Arg Ile Gly Thr Glu Val Ala Cys Arg Ala Cys Leu Pro Pro His 
            20                  25                  30          


Cys Ala Met Pro Pro Ile Asp Ala Phe Leu Cys Leu Pro Phe Ser Phe 
        35                  40                  45              


Ala Leu Val Ser Gly Lys Leu Tyr Gln Trp Lys Glu Pro Val Ile Ser 
    50                  55                  60                  


Ser Val His Ser Lys Val Lys Arg Thr Ala Glu Val Lys Glu Glu Ile 
65                  70                  75                  80  


Val Glu Lys Glu Met Lys Lys Leu Val His Ser Val Phe Asn Met Ala 
                85                  90                  95      


Asp Tyr Thr Phe Pro Leu Gln Val Asn Thr Trp 
            100                 105         


<210>  1683
<211>  49
<212>  PRT
<213>  Homo Sapiens

<400>  1683

Met Leu Arg Pro Ala Leu Pro Trp Leu Tyr Leu Gly Leu Cys Ser Leu 
1               5                   10                  15      


Leu Val Gly Glu Ala Glu Ala Pro Ser Pro Val Asp Pro Leu Glu Arg 
            20                  25                  30          


Ser Arg Pro Tyr Ala Val Leu Arg Gly Gln Asn Leu Asp Gln Thr Leu 
        35                  40                  45              


His 
    


<210>  1684
<211>  76
<212>  PRT
<213>  Homo Sapiens

<400>  1684

Met Leu Arg Pro Ala Leu Pro Trp Leu Tyr Leu Gly Leu Cys Ser Leu 
1               5                   10                  15      


Leu Val Gly Glu Ala Glu Ala Pro Ser Pro Val Asp Pro Leu Glu Arg 
            20                  25                  30          


Ser Arg Pro Tyr Ala Val Leu Arg Gly Gln Asn Leu Glu Ser Leu Ser 
        35                  40                  45              


Pro Arg Leu Glu Cys Asn Gly Ala Ile Ser Ala Arg Cys Asn Leu Arg 
    50                  55                  60                  


Val Trp Gly Ser Ser Asp Ser Pro Ala Ser Ala Pro 
65                  70                  75      


<210>  1685
<211>  76
<212>  PRT
<213>  Homo Sapiens

<400>  1685

Met Leu Arg Pro Ala Leu Pro Trp Leu Tyr Leu Gly Leu Cys Ser Leu 
1               5                   10                  15      


Leu Val Gly Glu Ala Glu Ala Pro Ser Pro Val Asp Pro Leu Glu Arg 
            20                  25                  30          


Ser Arg Pro Tyr Ala Val Leu Arg Gly Gln Asn Leu Glu Ser Leu Ser 
        35                  40                  45              


Pro Arg Leu Glu Cys Asn Gly Ala Ile Ser Ala Arg Cys Asn Leu Arg 
    50                  55                  60                  


Val Trp Gly Ser Ser Asp Ser Pro Ala Ser Ala Pro 
65                  70                  75      


<210>  1686
<211>  61
<212>  PRT
<213>  Homo Sapiens

<400>  1686

Met Leu Arg Pro Ala Leu Pro Trp Leu Tyr Leu Gly Leu Cys Ser Leu 
1               5                   10                  15      


Leu Val Gly Glu Ala Glu Ala Pro Ser Pro Val Asp Pro Leu Glu Arg 
            20                  25                  30          


Ser Arg Pro Tyr Ala Val Leu Arg Gly Gln Asn Leu Glu Thr Thr Gly 
        35                  40                  45              


Glu Arg Ile Cys Leu Gln Leu Phe Ala Gln His Leu Thr 
    50                  55                  60      


<210>  1687
<211>  72
<212>  PRT
<213>  Homo Sapiens

<400>  1687

Met Leu Arg Pro Ala Leu Pro Trp Leu Tyr Leu Gly Leu Cys Ser Leu 
1               5                   10                  15      


Leu Val Gly Glu Ala Glu Ala Pro Ser Pro Val Asp Pro Leu Glu Arg 
            20                  25                  30          


Ser Arg Pro Tyr Ala Val Leu Arg Gly Gln Asn Leu Val Leu Met Gly 
        35                  40                  45              


Thr Ile Phe Ser Ile Leu Leu Val Thr Val Ile Leu Met Ala Phe Cys 
    50                  55                  60                  


Val Tyr Lys Pro Ile Arg Arg Arg 
65                  70          


<210>  1688
<211>  126
<212>  PRT
<213>  Homo Sapiens

<400>  1688

Met Arg Leu Pro Gly Cys Thr Leu Ala Ala Ser Glu Ala Ala Pro Leu 
1               5                   10                  15      


Leu Asn Pro Leu Val Asp Asp Tyr Val Ala Ser Glu Gly Ala Val Gln 
            20                  25                  30          


Arg Val Leu Val Pro Ala Tyr Ala Lys Gln Leu Ser Pro Ala Thr Gln 
        35                  40                  45              


Leu Ala Ile Gln Arg Ala Thr Pro Glu Thr Gly Pro Glu Asn Gly Thr 
    50                  55                  60                  


Lys Leu Pro Pro Pro Arg Pro Glu Asp Met Leu Asn Ala Ala Ala Ala 
65                  70                  75                  80  


Leu Asp Ser Ala Leu Glu Glu Ser Gly Pro Gly Ser Thr Gly Glu Leu 
                85                  90                  95      


Arg His Ser Leu Gly Leu Thr Val Ser Pro Cys Arg Thr Arg Gly Ser 
            100                 105                 110         


Gly Gln Lys Asn Ser Arg Arg Lys Arg Asp Leu Val Leu Ser 
        115                 120                 125     


<210>  1689
<211>  358
<212>  PRT
<213>  Homo Sapiens

<400>  1689

Met Arg Leu Pro Gly Cys Thr Leu Ala Ala Ser Glu Ala Ala Pro Leu 
1               5                   10                  15      


Leu Asn Pro Leu Val Asp Asp Tyr Val Ala Ser Glu Gly Ala Val Gln 
            20                  25                  30          


Arg Val Leu Val Pro Ala Tyr Ala Lys Gln Leu Ser Pro Ala Thr Gln 
        35                  40                  45              


Leu Ala Ile Gln Arg Ala Thr Pro Glu Thr Gly Pro Glu Asn Gly Thr 
    50                  55                  60                  


Lys Leu Pro Pro Pro Arg Pro Glu Asp Met Leu Asn Ala Ala Ala Ala 
65                  70                  75                  80  


Leu Asp Ser Ala Leu Glu Glu Ser Gly Pro Gly Ser Thr Gly Glu Leu 
                85                  90                  95      


Arg His Ser Leu Gly Leu Thr Val Ser Pro Cys Arg Thr Arg Gly Ser 
            100                 105                 110         


Gly Gln Lys Asn Ser Arg Arg Lys Arg Asp Leu Val Leu Ser Lys Leu 
        115                 120                 125             


Val His Asn Val His Asn His Ile Thr Asn Asp Lys Arg Phe Asn Gly 
    130                 135                 140                 


Ser Glu Ser Ile Lys Ser Ser Trp Asn Ile Ser Val Val Lys Phe Leu 
145                 150                 155                 160 


Leu Glu Lys Leu Lys Gln Glu Leu Val Thr Ser Pro His Asn Tyr Thr 
                165                 170                 175     


Asp Lys Glu Leu Lys Gly Ala Cys Val Ala Tyr Phe Leu Thr Lys Arg 
            180                 185                 190         


Arg Glu Tyr Arg Asn Ser Leu Asn Pro Phe Lys Gly Leu Lys Glu Lys 
        195                 200                 205             


Glu Glu Lys Lys Leu Arg Ser Arg Arg Tyr Arg Leu Phe Ala Asn Arg 
    210                 215                 220                 


Ser Ser Ile Met Arg His Phe Gly Pro Glu Asp Gln Arg Leu Trp Asn 
225                 230                 235                 240 


Asp Val Thr Glu Glu Leu Met Ser Asp Glu Glu Asp Ser Leu Asn Glu 
                245                 250                 255     


Pro Gly Val Trp Val Ala Arg Pro Pro Arg Phe Arg Ala Gln Arg Leu 
            260                 265                 270         


Thr Glu Leu Cys Tyr His Leu Asp Ala Asn Ser Lys His Gly Thr Lys 
        275                 280                 285             


Ala Asn Arg Val Tyr Gly Pro Pro Ser Asp Arg Leu Pro Ser Ala Glu 
    290                 295                 300                 


Ala Gln Leu Leu Pro Pro Glu Leu Tyr Asn Pro Asn Phe Gln Glu Glu 
305                 310                 315                 320 


Glu Asp Glu Gly Gly Asp Glu Asn Ala Pro Gly Ser Pro Ser Phe Asp 
                325                 330                 335     


Gln Pro His Lys Thr Cys Cys Pro Asp Leu Asn Ser Phe Ile Glu Ile 
            340                 345                 350         


Lys Val Glu Lys Asp Glu 
        355             


<210>  1690
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  1690

Met Ser Phe Ser Ala Thr Ile Leu Phe 
1               5                   


<210>  1691
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  1691

Met Ser Phe Ser Ala Thr Ile Leu Phe 
1               5                   


<210>  1692
<211>  11
<212>  PRT
<213>  Homo Sapiens

<400>  1692

Met Ser Phe Ser Ala Thr Ile Leu Phe Ser Pro 
1               5                   10      


<210>  1693
<211>  50
<212>  PRT
<213>  Homo Sapiens

<400>  1693

Met Ser Phe Ser Ala Thr Ile Leu Phe Ser Pro Pro Ser Gly Ser Glu 
1               5                   10                  15      


Ala Arg Cys Cys Cys Cys Ala Cys Lys Ser Glu Thr Asn Gly Gly Asn 
            20                  25                  30          


Thr Gly Ser Gln Gly Gly Asn Pro Pro Pro Ser Thr Pro Ile Thr Val 
        35                  40                  45              


Thr Gly 
    50  


<210>  1694
<211>  79
<212>  PRT
<213>  Homo Sapiens

<400>  1694

Met Ser Phe Ser Ala Thr Ile Leu Phe Ser Pro Pro Ser Gly Ser Glu 
1               5                   10                  15      


Ala Arg Cys Cys Cys Cys Ala Cys Lys Ser Glu Thr Asn Gly Gly Asn 
            20                  25                  30          


Thr Gly Ser Gln Gly Gly Asn Pro Pro Pro Ser Thr Pro Ile Thr Val 
        35                  40                  45              


Thr Gly His Gly Leu Ala Val Gln Ser Ser Glu Gln Leu Leu His Val 
    50                  55                  60                  


Ile Tyr Gln Arg Val Asp Lys Ala Val Gly Leu Ala Glu Ala Ala 
65                  70                  75                  


<210>  1695
<211>  83
<212>  PRT
<213>  Homo Sapiens

<400>  1695

Met Ser Phe Ser Ala Thr Ile Leu Phe Ser Pro Pro Ser Gly Ser Glu 
1               5                   10                  15      


Ala Arg Cys Cys Cys Cys Ala Cys Lys Ser Glu Thr Asn Gly Gly Asn 
            20                  25                  30          


Thr Gly Ser Gln Gly Gly Asn Pro Pro Pro Ser Thr Pro Ile Thr Val 
        35                  40                  45              


Thr Gly His Gly Leu Ala Val Gln Ser Ser Glu Gln Leu Leu His Val 
    50                  55                  60                  


Ile Tyr Gln Arg Val Asp Lys Ala Val Gly Leu Ala Glu Ala Ala Leu 
65                  70                  75                  80  


Gly Leu Ala 
            


<210>  1696
<211>  106
<212>  PRT
<213>  Homo Sapiens

<400>  1696

Met Ser Phe Ser Ala Thr Ile Leu Phe Ser Pro Pro Ser Gly Ser Glu 
1               5                   10                  15      


Ala Arg Cys Cys Cys Cys Ala Cys Lys Ser Glu Thr Asn Gly Gly Asn 
            20                  25                  30          


Thr Gly Ser Gln Gly Gly Asn Pro Pro Pro Ser Thr Pro Ile Thr Val 
        35                  40                  45              


Thr Gly His Gly Leu Ala Val Gln Ser Ser Glu Gln Leu Leu His Val 
    50                  55                  60                  


Ile Tyr Gln Arg Val Asp Lys Ala Val Gly Leu Ala Glu Ala Ala Leu 
65                  70                  75                  80  


Gly Leu Ala Arg Ala Asn Asn Glu Leu Leu Lys Arg Leu Gln Glu Glu 
                85                  90                  95      


Val Gly Asp Leu Arg Gln Gly Lys Val Ser 
            100                 105     


<210>  1697
<211>  136
<212>  PRT
<213>  Homo Sapiens

<400>  1697

Met Ser Phe Ser Ala Thr Ile Leu Phe Ser Pro Pro Ser Gly Ser Glu 
1               5                   10                  15      


Ala Arg Cys Cys Cys Cys Ala Cys Lys Ser Glu Thr Asn Gly Gly Asn 
            20                  25                  30          


Thr Gly Ser Gln Gly Gly Asn Pro Pro Pro Ser Thr Pro Ile Thr Val 
        35                  40                  45              


Thr Gly His Gly Leu Ala Val Gln Ser Ser Glu Gln Leu Leu His Val 
    50                  55                  60                  


Ile Tyr Gln Arg Val Asp Lys Ala Val Gly Leu Ala Glu Ala Ala Leu 
65                  70                  75                  80  


Gly Leu Ala Arg Ala Asn Asn Glu Leu Leu Lys Arg Leu Gln Glu Glu 
                85                  90                  95      


Val Gly Asp Leu Arg Gln Gly Lys Val Ser Ile Pro Asp Glu Asp Gly 
            100                 105                 110         


Glu Ser Arg Ala His Ser Ser Pro Pro Glu Glu Pro Gly Pro Leu Lys 
        115                 120                 125             


Glu Ser Pro Gly Glu Ala Phe Lys 
    130                 135     


<210>  1698
<211>  199
<212>  PRT
<213>  Homo Sapiens

<400>  1698

Met Ser Phe Ser Ala Thr Ile Leu Phe Ser Pro Pro Ser Gly Ser Glu 
1               5                   10                  15      


Ala Arg Cys Cys Cys Cys Ala Cys Lys Ser Glu Thr Asn Gly Gly Asn 
            20                  25                  30          


Thr Gly Ser Gln Gly Gly Asn Pro Pro Pro Ser Thr Pro Ile Thr Val 
        35                  40                  45              


Thr Gly His Gly Leu Ala Val Gln Ser Ser Glu Gln Leu Leu His Val 
    50                  55                  60                  


Ile Tyr Gln Arg Val Asp Lys Ala Val Gly Leu Ala Glu Ala Ala Leu 
65                  70                  75                  80  


Gly Leu Ala Arg Ala Asn Asn Glu Leu Leu Lys Arg Leu Gln Glu Glu 
                85                  90                  95      


Val Gly Asp Leu Arg Gln Gly Lys Val Ser Ile Pro Asp Glu Asp Gly 
            100                 105                 110         


Glu Ser Arg Ala His Ser Ser Pro Pro Glu Glu Pro Gly Pro Leu Lys 
        115                 120                 125             


Glu Ser Pro Gly Glu Ala Phe Lys Ala Leu Ser Ala Val Glu Glu Glu 
    130                 135                 140                 


Cys Asp Ser Val Gly Ser Gly Val Gln Val Val Ile Glu Glu Leu Arg 
145                 150                 155                 160 


Gln Leu Gly Ala Ala Ser Val Gly Pro Gly Pro Leu Gly Phe Pro Ala 
                165                 170                 175     


Thr Gln Arg Asp Met Arg Leu Pro Gly Cys Thr Leu Ala Ala Ser Glu 
            180                 185                 190         


Ala Ala Pro Leu Leu Asn Pro 
        195                 


<210>  1699
<211>  209
<212>  PRT
<213>  Homo Sapiens

<400>  1699

Met Ser Phe Ser Ala Thr Ile Leu Phe Ser Pro Pro Ser Gly Ser Glu 
1               5                   10                  15      


Ala Arg Cys Cys Cys Cys Ala Cys Lys Ser Glu Thr Asn Gly Gly Asn 
            20                  25                  30          


Thr Gly Ser Gln Gly Gly Asn Pro Pro Pro Ser Thr Pro Ile Thr Val 
        35                  40                  45              


Thr Gly His Gly Leu Ala Val Gln Ser Ser Glu Gln Leu Leu His Val 
    50                  55                  60                  


Ile Tyr Gln Arg Val Asp Lys Ala Val Gly Leu Ala Glu Ala Ala Leu 
65                  70                  75                  80  


Gly Leu Ala Arg Ala Asn Asn Glu Leu Leu Lys Arg Leu Gln Glu Glu 
                85                  90                  95      


Val Gly Asp Leu Arg Gln Gly Lys Val Ser Ile Pro Asp Glu Asp Gly 
            100                 105                 110         


Glu Ser Arg Ala His Ser Ser Pro Pro Glu Glu Pro Gly Pro Leu Lys 
        115                 120                 125             


Glu Ser Pro Gly Glu Ala Phe Lys Ala Leu Ser Ala Val Glu Glu Glu 
    130                 135                 140                 


Cys Asp Ser Val Gly Ser Gly Val Gln Val Val Ile Glu Glu Leu Arg 
145                 150                 155                 160 


Gln Leu Gly Ala Ala Ser Val Gly Pro Gly Pro Leu Gly Phe Pro Ala 
                165                 170                 175     


Thr Gln Arg Asp Met Arg Leu Pro Gly Cys Thr Leu Ala Ala Ser Glu 
            180                 185                 190         


Ala Ala Pro Leu Leu Asn Pro Leu Val Asp Asp Tyr Val Ala Ser Glu 
        195                 200                 205             


Gly 
    


<210>  1700
<211>  498
<212>  PRT
<213>  Homo Sapiens

<400>  1700

Met Ser Phe Ser Ala Thr Ile Leu Phe Ser Pro Pro Ser Gly Ser Glu 
1               5                   10                  15      


Ala Arg Cys Cys Cys Cys Ala Cys Lys Ser Glu Thr Asn Gly Gly Asn 
            20                  25                  30          


Thr Gly Ser Gln Gly Gly Asn Pro Pro Pro Ser Thr Pro Ile Thr Val 
        35                  40                  45              


Thr Gly His Gly Leu Ala Val Gln Ser Ser Glu Gln Leu Leu His Val 
    50                  55                  60                  


Ile Tyr Gln Arg Val Asp Lys Ala Val Gly Leu Ala Glu Ala Ala Leu 
65                  70                  75                  80  


Gly Leu Ala Arg Ala Asn Asn Glu Leu Leu Lys Arg Leu Gln Glu Glu 
                85                  90                  95      


Val Gly Asp Leu Arg Gln Gly Lys Val Ser Ile Pro Asp Glu Asp Gly 
            100                 105                 110         


Glu Ser Arg Ala His Ser Ser Pro Pro Glu Glu Pro Gly Pro Leu Lys 
        115                 120                 125             


Glu Ser Pro Gly Glu Ala Phe Lys Ala Leu Ser Ala Val Glu Glu Glu 
    130                 135                 140                 


Cys Asp Ser Val Gly Ser Gly Val Gln Val Val Ile Glu Glu Leu Arg 
145                 150                 155                 160 


Gln Leu Gly Ala Ala Ser Val Gly Pro Gly Pro Leu Gly Phe Pro Ala 
                165                 170                 175     


Thr Gln Arg Asp Met Arg Leu Pro Gly Cys Thr Leu Ala Ala Ser Glu 
            180                 185                 190         


Ala Ala Pro Leu Leu Asn Pro Leu Val Asp Asp Tyr Val Ala Ser Glu 
        195                 200                 205             


Gly Ala Val Gln Arg Val Leu Val Pro Ala Tyr Ala Lys Gln Leu Ser 
    210                 215                 220                 


Pro Ala Thr Gln Leu Ala Ile Gln Arg Ala Thr Pro Glu Thr Gly Pro 
225                 230                 235                 240 


Glu Asn Gly Thr Lys Leu Pro Pro Pro Arg Pro Glu Asp Met Leu Asn 
                245                 250                 255     


Ala Ala Ala Ala Leu Asp Ser Ala Leu Glu Glu Ser Gly Pro Gly Ser 
            260                 265                 270         


Thr Gly Glu Leu Arg His Ser Leu Gly Leu Thr Val Ser Pro Cys Arg 
        275                 280                 285             


Thr Arg Gly Ser Gly Gln Lys Asn Ser Arg Arg Lys Arg Asp Leu Val 
    290                 295                 300                 


Leu Ser Lys Leu Val His Asn Val His Asn His Ile Thr Asn Asp Lys 
305                 310                 315                 320 


Arg Phe Asn Gly Ser Glu Ser Ile Lys Ser Ser Trp Asn Ile Ser Val 
                325                 330                 335     


Val Lys Phe Leu Leu Glu Lys Leu Lys Gln Glu Leu Val Thr Ser Pro 
            340                 345                 350         


His Asn Tyr Thr Asp Lys Glu Leu Lys Gly Ala Cys Val Ala Tyr Phe 
        355                 360                 365             


Leu Thr Lys Arg Arg Glu Tyr Arg Asn Ser Leu Asn Pro Phe Lys Gly 
    370                 375                 380                 


Leu Lys Glu Lys Glu Glu Lys Lys Leu Arg Ser Arg Arg Tyr Arg Leu 
385                 390                 395                 400 


Phe Ala Asn Arg Ser Ser Ile Met Arg His Phe Gly Pro Glu Asp Gln 
                405                 410                 415     


Arg Leu Trp Asn Asp Val Thr Glu Glu Leu Met Ser Asp Glu Glu Asp 
            420                 425                 430         


Ser Leu Asn Glu Pro Asp Arg Leu Pro Ser Ala Glu Ala Gln Leu Leu 
        435                 440                 445             


Pro Pro Glu Leu Tyr Asn Pro Asn Phe Gln Glu Glu Glu Asp Glu Gly 
    450                 455                 460                 


Gly Asp Glu Asn Ala Pro Gly Ser Pro Ser Phe Asp Gln Pro His Lys 
465                 470                 475                 480 


Thr Cys Cys Pro Asp Leu Asn Ser Phe Ile Glu Ile Lys Val Glu Lys 
                485                 490                 495     


Asp Glu 
        


<210>  1701
<211>  538
<212>  PRT
<213>  Homo Sapiens

<400>  1701

Met Ser Phe Ser Ala Thr Ile Leu Phe Ser Pro Pro Ser Gly Ser Glu 
1               5                   10                  15      


Ala Arg Cys Cys Cys Cys Ala Cys Lys Ser Glu Thr Asn Gly Gly Asn 
            20                  25                  30          


Thr Gly Ser Gln Gly Gly Asn Pro Pro Pro Ser Thr Pro Ile Thr Val 
        35                  40                  45              


Thr Gly His Gly Leu Ala Val Gln Ser Ser Glu Gln Leu Leu His Val 
    50                  55                  60                  


Ile Tyr Gln Arg Val Asp Lys Ala Val Gly Leu Ala Glu Ala Ala Leu 
65                  70                  75                  80  


Gly Leu Ala Arg Ala Asn Asn Glu Leu Leu Lys Arg Leu Gln Glu Glu 
                85                  90                  95      


Val Gly Asp Leu Arg Gln Gly Lys Val Ser Ile Pro Asp Glu Asp Gly 
            100                 105                 110         


Glu Ser Arg Ala His Ser Ser Pro Pro Glu Glu Pro Gly Pro Leu Lys 
        115                 120                 125             


Glu Ser Pro Gly Glu Ala Phe Lys Ala Leu Ser Ala Val Glu Glu Glu 
    130                 135                 140                 


Cys Asp Ser Val Gly Ser Gly Val Gln Val Val Ile Glu Glu Leu Arg 
145                 150                 155                 160 


Gln Leu Gly Ala Ala Ser Val Gly Pro Gly Pro Leu Gly Phe Pro Ala 
                165                 170                 175     


Thr Gln Arg Asp Met Arg Leu Pro Gly Cys Thr Leu Ala Ala Ser Glu 
            180                 185                 190         


Ala Ala Pro Leu Leu Asn Pro Leu Val Asp Asp Tyr Val Ala Ser Glu 
        195                 200                 205             


Gly Ala Val Gln Arg Val Leu Val Pro Ala Tyr Ala Lys Gln Leu Ser 
    210                 215                 220                 


Pro Ala Thr Gln Leu Ala Ile Gln Arg Ala Thr Pro Glu Thr Gly Pro 
225                 230                 235                 240 


Glu Asn Gly Thr Lys Leu Pro Pro Pro Arg Pro Glu Asp Met Leu Asn 
                245                 250                 255     


Ala Ala Ala Ala Leu Asp Ser Ala Leu Glu Glu Ser Gly Pro Gly Ser 
            260                 265                 270         


Thr Gly Glu Leu Arg His Ser Leu Gly Leu Thr Val Ser Pro Cys Arg 
        275                 280                 285             


Thr Arg Gly Ser Gly Gln Lys Asn Ser Arg Arg Lys Arg Asp Leu Val 
    290                 295                 300                 


Leu Ser Lys Leu Val His Asn Val His Asn His Ile Thr Asn Asp Lys 
305                 310                 315                 320 


Arg Phe Asn Gly Ser Glu Ser Ile Lys Ser Ser Trp Asn Ile Ser Val 
                325                 330                 335     


Val Lys Phe Leu Leu Glu Lys Leu Lys Gln Glu Leu Val Thr Ser Pro 
            340                 345                 350         


His Asn Tyr Thr Asp Lys Glu Leu Lys Gly Ala Cys Val Ala Tyr Phe 
        355                 360                 365             


Leu Thr Lys Arg Arg Glu Tyr Arg Asn Ser Leu Asn Pro Phe Lys Gly 
    370                 375                 380                 


Leu Lys Glu Lys Glu Glu Lys Lys Leu Arg Ser Arg Arg Tyr Arg Leu 
385                 390                 395                 400 


Phe Ala Asn Arg Ser Ser Ile Met Arg His Phe Gly Pro Glu Asp Gln 
                405                 410                 415     


Arg Leu Trp Asn Asp Val Thr Glu Glu Leu Met Ser Asp Glu Glu Asp 
            420                 425                 430         


Ser Leu Asn Glu Pro Gly Val Trp Val Ala Arg Pro Pro Arg Phe Arg 
        435                 440                 445             


Ala Gln Arg Leu Thr Glu Leu Cys Tyr His Leu Asp Ala Asn Ser Lys 
    450                 455                 460                 


His Gly Thr Lys Ala Asn Arg Val Tyr Gly Pro Pro Ser Asp Arg Leu 
465                 470                 475                 480 


Pro Ser Ala Glu Ala Gln Leu Leu Pro Pro Glu Leu Tyr Asn Pro Asn 
                485                 490                 495     


Phe Gln Glu Glu Glu Asp Glu Gly Gly Asp Glu Asn Ala Pro Gly Ser 
            500                 505                 510         


Pro Ser Phe Asp Gln Pro His Lys Thr Cys Cys Pro Asp Leu Asn Ser 
        515                 520                 525             


Phe Ile Glu Ile Lys Val Glu Lys Asp Glu 
    530                 535             


<210>  1702
<211>  538
<212>  PRT
<213>  Homo Sapiens

<400>  1702

Met Ser Phe Ser Ala Thr Ile Leu Phe Ser Pro Pro Ser Gly Ser Glu 
1               5                   10                  15      


Ala Arg Cys Cys Cys Cys Ala Cys Lys Ser Glu Thr Asn Gly Gly Asn 
            20                  25                  30          


Thr Gly Ser Gln Gly Gly Asn Pro Pro Pro Ser Thr Pro Ile Thr Val 
        35                  40                  45              


Thr Gly His Gly Leu Ala Val Gln Ser Ser Glu Gln Leu Leu His Val 
    50                  55                  60                  


Ile Tyr Gln Arg Val Asp Lys Ala Val Gly Leu Ala Glu Ala Ala Leu 
65                  70                  75                  80  


Gly Leu Ala Arg Ala Asn Asn Glu Leu Leu Lys Arg Leu Gln Glu Glu 
                85                  90                  95      


Val Gly Asp Leu Arg Gln Gly Lys Val Ser Ile Pro Asp Glu Asp Gly 
            100                 105                 110         


Glu Ser Arg Ala His Ser Ser Pro Pro Glu Glu Pro Gly Pro Leu Lys 
        115                 120                 125             


Glu Ser Pro Gly Glu Ala Phe Lys Ala Leu Ser Ala Val Glu Glu Glu 
    130                 135                 140                 


Cys Asp Ser Val Gly Ser Gly Val Gln Val Val Ile Glu Glu Leu Arg 
145                 150                 155                 160 


Gln Leu Gly Ala Ala Ser Val Gly Pro Gly Pro Leu Gly Phe Pro Ala 
                165                 170                 175     


Thr Gln Arg Asp Met Arg Leu Pro Gly Cys Thr Leu Ala Ala Ser Glu 
            180                 185                 190         


Ala Ala Pro Leu Leu Asn Pro Leu Val Asp Asp Tyr Val Ala Ser Glu 
        195                 200                 205             


Gly Ala Val Gln Arg Val Leu Val Pro Ala Tyr Ala Lys Gln Leu Ser 
    210                 215                 220                 


Pro Ala Thr Gln Leu Ala Ile Gln Arg Ala Thr Pro Glu Thr Gly Pro 
225                 230                 235                 240 


Glu Asn Gly Thr Lys Leu Pro Pro Pro Arg Pro Glu Asp Met Leu Asn 
                245                 250                 255     


Ala Ala Ala Ala Leu Asp Ser Ala Leu Glu Glu Ser Gly Pro Gly Ser 
            260                 265                 270         


Thr Gly Glu Leu Arg His Ser Leu Gly Leu Thr Val Ser Pro Cys Arg 
        275                 280                 285             


Thr Arg Gly Ser Gly Gln Lys Asn Ser Arg Arg Lys Arg Asp Leu Val 
    290                 295                 300                 


Leu Ser Lys Leu Val His Asn Val His Asn His Ile Thr Asn Asp Lys 
305                 310                 315                 320 


Arg Phe Asn Gly Ser Glu Ser Ile Lys Ser Ser Trp Asn Ile Ser Val 
                325                 330                 335     


Val Lys Phe Leu Leu Glu Lys Leu Lys Gln Glu Leu Val Thr Ser Pro 
            340                 345                 350         


His Asn Tyr Thr Asp Lys Glu Leu Lys Gly Ala Cys Val Ala Tyr Phe 
        355                 360                 365             


Leu Thr Lys Arg Arg Glu Tyr Arg Asn Ser Leu Asn Pro Phe Lys Gly 
    370                 375                 380                 


Leu Lys Glu Lys Glu Glu Lys Lys Leu Arg Ser Arg Arg Tyr Arg Leu 
385                 390                 395                 400 


Phe Ala Asn Arg Ser Ser Ile Met Arg His Phe Gly Pro Glu Asp Gln 
                405                 410                 415     


Arg Leu Trp Asn Asp Val Thr Glu Glu Leu Met Ser Asp Glu Glu Asp 
            420                 425                 430         


Ser Leu Asn Glu Pro Gly Val Trp Val Ala Arg Pro Pro Arg Phe Arg 
        435                 440                 445             


Ala Gln Arg Leu Thr Glu Leu Cys Tyr His Leu Asp Ala Asn Ser Lys 
    450                 455                 460                 


His Gly Thr Lys Ala Asn Arg Val Tyr Gly Pro Pro Ser Asp Arg Leu 
465                 470                 475                 480 


Pro Ser Ala Glu Ala Gln Leu Leu Pro Pro Glu Leu Tyr Asn Pro Asn 
                485                 490                 495     


Phe Gln Glu Glu Glu Asp Glu Gly Gly Asp Glu Asn Ala Pro Gly Ser 
            500                 505                 510         


Pro Ser Phe Asp Gln Pro His Lys Thr Cys Cys Pro Asp Leu Asn Ser 
        515                 520                 525             


Phe Ile Glu Ile Lys Val Glu Lys Asp Glu 
    530                 535             


<210>  1703
<211>  538
<212>  PRT
<213>  Homo Sapiens

<400>  1703

Met Ser Phe Ser Ala Thr Ile Leu Phe Ser Pro Pro Ser Gly Ser Glu 
1               5                   10                  15      


Ala Arg Cys Cys Cys Cys Ala Cys Lys Ser Glu Thr Asn Gly Gly Asn 
            20                  25                  30          


Thr Gly Ser Gln Gly Gly Asn Pro Pro Pro Ser Thr Pro Ile Thr Val 
        35                  40                  45              


Thr Gly His Gly Leu Ala Val Gln Ser Ser Glu Gln Leu Leu His Val 
    50                  55                  60                  


Ile Tyr Gln Arg Val Asp Lys Ala Val Gly Leu Ala Glu Ala Ala Leu 
65                  70                  75                  80  


Gly Leu Ala Arg Ala Asn Asn Glu Leu Leu Lys Arg Leu Gln Glu Glu 
                85                  90                  95      


Val Gly Asp Leu Arg Gln Gly Lys Val Ser Ile Pro Asp Glu Asp Gly 
            100                 105                 110         


Glu Ser Arg Ala His Ser Ser Pro Pro Glu Glu Pro Gly Pro Leu Lys 
        115                 120                 125             


Glu Ser Pro Gly Glu Ala Phe Lys Ala Leu Ser Ala Val Glu Glu Glu 
    130                 135                 140                 


Cys Asp Ser Val Gly Ser Gly Val Gln Val Val Ile Glu Glu Leu Arg 
145                 150                 155                 160 


Gln Leu Gly Ala Ala Ser Val Gly Pro Gly Pro Leu Gly Phe Pro Ala 
                165                 170                 175     


Thr Gln Arg Asp Met Arg Leu Pro Gly Cys Thr Leu Ala Ala Ser Glu 
            180                 185                 190         


Ala Ala Pro Leu Leu Asn Pro Leu Val Asp Asp Tyr Val Ala Ser Glu 
        195                 200                 205             


Gly Ala Val Gln Arg Val Leu Val Pro Ala Tyr Ala Lys Gln Leu Ser 
    210                 215                 220                 


Pro Ala Thr Gln Leu Ala Ile Gln Arg Ala Thr Pro Glu Thr Gly Pro 
225                 230                 235                 240 


Glu Asn Gly Thr Lys Leu Pro Pro Pro Arg Pro Glu Asp Met Leu Asn 
                245                 250                 255     


Ala Ala Ala Ala Leu Asp Ser Ala Leu Glu Glu Ser Gly Pro Gly Ser 
            260                 265                 270         


Thr Gly Glu Leu Arg His Ser Leu Gly Leu Thr Val Ser Pro Cys Arg 
        275                 280                 285             


Thr Arg Gly Ser Gly Gln Lys Asn Ser Arg Arg Lys Arg Asp Leu Val 
    290                 295                 300                 


Leu Ser Lys Leu Val His Asn Val His Asn His Ile Thr Asn Asp Lys 
305                 310                 315                 320 


Arg Phe Asn Gly Ser Glu Ser Ile Lys Ser Ser Trp Asn Ile Ser Val 
                325                 330                 335     


Val Lys Phe Leu Leu Glu Lys Leu Lys Gln Glu Leu Val Thr Ser Pro 
            340                 345                 350         


His Asn Tyr Thr Asp Lys Glu Leu Lys Gly Ala Cys Val Ala Tyr Phe 
        355                 360                 365             


Leu Thr Lys Arg Arg Glu Tyr Arg Asn Ser Leu Asn Pro Phe Lys Gly 
    370                 375                 380                 


Leu Lys Glu Lys Glu Glu Lys Lys Leu Arg Ser Arg Arg Tyr Arg Leu 
385                 390                 395                 400 


Phe Ala Asn Arg Ser Ser Ile Met Arg His Phe Gly Pro Glu Asp Gln 
                405                 410                 415     


Arg Leu Trp Asn Asp Val Thr Glu Glu Leu Met Ser Asp Glu Glu Asp 
            420                 425                 430         


Ser Leu Asn Glu Pro Gly Val Trp Val Ala Arg Pro Pro Arg Phe Arg 
        435                 440                 445             


Ala Gln Arg Leu Thr Glu Leu Cys Tyr His Leu Asp Ala Asn Ser Lys 
    450                 455                 460                 


His Gly Thr Lys Ala Asn Arg Val Tyr Gly Pro Pro Ser Asp Arg Leu 
465                 470                 475                 480 


Pro Ser Ala Glu Ala Gln Leu Leu Pro Pro Glu Leu Tyr Asn Pro Asn 
                485                 490                 495     


Phe Gln Glu Glu Glu Asp Glu Gly Gly Asp Glu Asn Ala Pro Gly Ser 
            500                 505                 510         


Pro Ser Phe Asp Gln Pro His Lys Thr Cys Cys Pro Asp Leu Asn Ser 
        515                 520                 525             


Phe Ile Glu Ile Lys Val Glu Lys Asp Glu 
    530                 535             


<210>  1704
<211>  402
<212>  PRT
<213>  Homo Sapiens

<400>  1704

Met Ala Ser Leu Gly Leu Leu Leu Leu Leu Leu Leu Thr Ala Leu Pro 
1               5                   10                  15      


Pro Leu Trp Ser Ser Ser Leu Pro Gly Leu Asp Thr Ala Glu Ser Lys 
            20                  25                  30          


Ala Thr Ile Ala Asp Leu Ile Leu Ser Ala Leu Glu Arg Ala Thr Val 
        35                  40                  45              


Phe Leu Glu Gln Arg Leu Pro Glu Ile Asn Leu Asp Gly Met Val Gly 
    50                  55                  60                  


Val Arg Val Leu Glu Glu Gln Leu Lys Ser Val Arg Glu Lys Trp Ala 
65                  70                  75                  80  


Gln Glu Pro Leu Leu Gln Pro Leu Ser Leu Arg Val Gly Met Leu Gly 
                85                  90                  95      


Glu Lys Leu Glu Ala Ala Ile Gln Arg Ser Leu His Tyr Leu Lys Leu 
            100                 105                 110         


Ser Asp Pro Lys Tyr Leu Arg Glu Phe Gln Leu Thr Leu Gln Pro Gly 
        115                 120                 125             


Phe Trp Lys Leu Pro His Ala Trp Ile His Thr Asp Ala Ser Leu Val 
    130                 135                 140                 


Tyr Pro Thr Phe Gly Pro Gln Asp Ser Phe Ser Glu Glu Arg Ser Asp 
145                 150                 155                 160 


Val Cys Leu Val Gln Leu Leu Gly Thr Gly Thr Asp Ser Ser Glu Pro 
                165                 170                 175     


Cys Gly Leu Ser Asp Leu Cys Arg Ser Leu Met Thr Lys Pro Gly Cys 
            180                 185                 190         


Ser Gly Tyr Cys Leu Ser His Gln Leu Leu Phe Phe Leu Trp Ala Arg 
        195                 200                 205             


Met Arg Gly Cys Thr Gln Gly Pro Leu Gln Gln Ser Gln Asp Tyr Ile 
    210                 215                 220                 


Asn Leu Phe Cys Ala Asn Met Met Asp Leu Asn Arg Arg Ala Glu Ala 
225                 230                 235                 240 


Ile Gly Tyr Ala Tyr Pro Thr Arg Asp Ile Phe Met Glu Asn Ile Met 
                245                 250                 255     


Phe Cys Gly Met Gly Gly Phe Ser Asp Phe Tyr Lys Leu Arg Trp Leu 
            260                 265                 270         


Glu Ala Ile Leu Ser Trp Gln Lys Gln Gln Glu Gly Cys Phe Gly Glu 
        275                 280                 285             


Pro Asp Ala Glu Asp Glu Glu Leu Ser Lys Ala Ile Gln Tyr Gln Gln 
    290                 295                 300                 


His Phe Ser Arg Arg Val Lys Arg Arg Glu Lys Gln Phe Pro Asp Ser 
305                 310                 315                 320 


Arg Ser Val Ala Gln Ala Gly Val Gln Trp Arg Asn Leu Gly Ser Leu 
                325                 330                 335     


Gln Pro Leu Pro Pro Gly Phe Lys Gln Phe Ser Cys Leu Ile Leu Pro 
            340                 345                 350         


Ser Ser Trp Asp Tyr Arg Ser Val Pro Pro Tyr Leu Ala Asn Phe Tyr 
        355                 360                 365             


Ile Phe Leu Val Glu Thr Gly Phe His His Val Ala His Ala Gly Leu 
    370                 375                 380                 


Glu Leu Leu Ile Ser Arg Asp Pro Pro Thr Ser Gly Ser Gln Ser Val 
385                 390                 395                 400 


Gly Leu 
        


<210>  1705
<211>  361
<212>  PRT
<213>  Homo Sapiens

<400>  1705

Met Ala Ser Leu Gly Leu Leu Leu Leu Leu Leu Leu Thr Ala Leu Pro 
1               5                   10                  15      


Pro Leu Trp Ser Ser Ser Leu Pro Gly Leu Asp Thr Ala Glu Ser Lys 
            20                  25                  30          


Ala Thr Ile Ala Asp Leu Ile Leu Ser Ala Leu Glu Arg Ala Thr Val 
        35                  40                  45              


Phe Leu Glu Gln Arg Leu Pro Glu Ile Asn Leu Asp Gly Met Val Gly 
    50                  55                  60                  


Val Arg Val Leu Glu Glu Gln Leu Lys Ser Val Arg Glu Lys Trp Ala 
65                  70                  75                  80  


Gln Glu Pro Leu Leu Gln Pro Leu Ser Leu Arg Val Gly Met Leu Gly 
                85                  90                  95      


Glu Lys Leu Glu Ala Ala Ile Gln Arg Ser Leu His Tyr Leu Lys Leu 
            100                 105                 110         


Ser Asp Pro Lys Tyr Leu Arg Glu Phe Gln Leu Thr Leu Gln Pro Gly 
        115                 120                 125             


Phe Trp Lys Leu Pro His Ala Trp Ile His Thr Asp Ala Ser Leu Val 
    130                 135                 140                 


Tyr Pro Thr Phe Gly Pro Gln Asp Ser Phe Ser Glu Glu Arg Ser Asp 
145                 150                 155                 160 


Val Cys Leu Val Gln Leu Leu Gly Thr Gly Thr Asp Ser Ser Glu Pro 
                165                 170                 175     


Cys Gly Leu Ser Asp Leu Cys Arg Ser Leu Met Thr Lys Pro Gly Cys 
            180                 185                 190         


Ser Gly Tyr Cys Leu Ser His Gln Leu Leu Phe Phe Leu Trp Ala Arg 
        195                 200                 205             


Met Arg Gly Cys Thr Gln Gly Pro Leu Gln Gln Ser Gln Asp Tyr Ile 
    210                 215                 220                 


Asn Leu Phe Cys Ala Asn Met Met Asp Leu Asn Arg Arg Ala Glu Ala 
225                 230                 235                 240 


Ile Gly Tyr Ala Tyr Pro Thr Arg Asp Ile Phe Met Glu Asn Ile Met 
                245                 250                 255     


Phe Cys Gly Met Gly Gly Phe Ser Asp Phe Tyr Lys Leu Arg Trp Leu 
            260                 265                 270         


Glu Ala Ile Leu Ser Trp Gln Lys Gln Gln Glu Gly Cys Phe Gly Glu 
        275                 280                 285             


Pro Asp Ala Glu Asp Glu Glu Leu Ser Lys Ala Ile Gln Tyr Gln Gln 
    290                 295                 300                 


His Phe Ser Arg Arg Val Lys Arg Arg Glu Lys Gln Phe Pro Asp Gly 
305                 310                 315                 320 


Cys Ser Ser His Asn Thr Ala Thr Ala Val Ala Ala Leu Gly Gly Phe 
                325                 330                 335     


Leu Tyr Ile Leu Ala Glu Tyr Pro Pro Ala Asn Arg Glu Pro His Pro 
            340                 345                 350         


Ser Thr Pro Pro Pro Pro Ser Ser Arg 
        355                 360     


<210>  1706
<211>  434
<212>  PRT
<213>  Homo Sapiens

<400>  1706

Met Ala Ser Leu Gly Leu Leu Leu Leu Leu Leu Leu Thr Ala Leu Pro 
1               5                   10                  15      


Pro Leu Trp Ser Ser Ser Leu Pro Gly Leu Asp Thr Ala Glu Ser Lys 
            20                  25                  30          


Ala Thr Ile Ala Asp Leu Ile Leu Ser Ala Leu Glu Arg Ala Thr Val 
        35                  40                  45              


Phe Leu Glu Gln Arg Leu Pro Glu Ile Asn Leu Asp Gly Met Val Gly 
    50                  55                  60                  


Val Arg Val Leu Glu Glu Gln Leu Lys Ser Val Arg Glu Lys Trp Ala 
65                  70                  75                  80  


Gln Glu Pro Leu Leu Gln Pro Leu Ser Leu Arg Val Gly Met Leu Gly 
                85                  90                  95      


Glu Lys Leu Glu Ala Ala Ile Gln Arg Ser Leu His Tyr Leu Lys Leu 
            100                 105                 110         


Ser Asp Pro Lys Tyr Leu Arg Glu Phe Gln Leu Thr Leu Gln Pro Gly 
        115                 120                 125             


Phe Trp Lys Leu Pro His Ala Trp Ile His Thr Asp Ala Ser Leu Val 
    130                 135                 140                 


Tyr Pro Thr Phe Gly Pro Gln Asp Ser Phe Ser Glu Glu Arg Ser Asp 
145                 150                 155                 160 


Val Cys Leu Val Gln Leu Leu Gly Thr Gly Thr Asp Ser Ser Glu Pro 
                165                 170                 175     


Cys Gly Leu Ser Asp Leu Cys Arg Ser Leu Met Thr Lys Pro Gly Cys 
            180                 185                 190         


Ser Gly Tyr Cys Leu Ser His Gln Leu Leu Phe Phe Leu Trp Ala Arg 
        195                 200                 205             


Met Arg Gly Cys Thr Gln Gly Pro Leu Gln Gln Ser Gln Asp Tyr Ile 
    210                 215                 220                 


Asn Leu Phe Cys Ala Asn Met Met Asp Leu Asn Arg Arg Ala Glu Ala 
225                 230                 235                 240 


Ile Gly Tyr Ala Tyr Pro Thr Arg Asp Ile Phe Met Glu Asn Asn Val 
                245                 250                 255     


Thr Gly His Pro Val Phe Tyr Leu Pro Leu Cys Asp Ser Phe Leu Pro 
            260                 265                 270         


Pro Lys Ala Ala Pro Val Thr Glu Leu Tyr Thr Asp Gly Pro Val Met 
        275                 280                 285             


Phe Cys Gly Met Gly Gly Phe Ser Asp Phe Tyr Lys Leu Arg Trp Leu 
    290                 295                 300                 


Glu Ala Ile Leu Ser Trp Gln Lys Gln Gln Glu Gly Cys Phe Gly Glu 
305                 310                 315                 320 


Pro Asp Ala Glu Asp Glu Glu Leu Ser Lys Ala Ile Gln Tyr Gln Gln 
                325                 330                 335     


His Phe Ser Arg Arg Val Lys Arg Arg Glu Lys Gln Phe Pro Asp Ser 
            340                 345                 350         


Arg Ser Val Ala Gln Ala Gly Val Gln Trp Arg Asn Leu Gly Ser Leu 
        355                 360                 365             


Gln Pro Leu Pro Pro Gly Phe Lys Gln Phe Ser Cys Leu Ile Leu Pro 
    370                 375                 380                 


Ser Ser Trp Asp Tyr Arg Ser Val Pro Pro Tyr Leu Ala Asn Phe Tyr 
385                 390                 395                 400 


Ile Phe Leu Val Glu Thr Gly Phe His His Val Ala His Ala Gly Leu 
                405                 410                 415     


Glu Leu Leu Ile Ser Arg Asp Pro Pro Thr Ser Gly Ser Gln Ser Val 
            420                 425                 430         


Gly Leu 
        


<210>  1707
<211>  182
<212>  PRT
<213>  Homo Sapiens

<400>  1707

Met Glu Ala Leu Val Cys Ala Phe Ser Glu Leu His Ile Arg Glu Asp 
1               5                   10                  15      


Ala Val Ser Gln Ala Gln Gly Arg Pro Gly His Pro Asp Ala Pro Pro 
            20                  25                  30          


Asn Ile Tyr Glu Gly Gly Leu Gly Ser Pro Gln Pro Gln Cys Pro Ser 
        35                  40                  45              


Ala Gln Gly Ser Lys Pro Lys Asn Phe Arg Leu Arg His Leu Arg Gly 
    50                  55                  60                  


Leu Gly Leu Tyr Leu Glu Ser His Pro Pro Pro Thr Gly Gln Cys Glu 
65                  70                  75                  80  


Ser His Trp Leu Gly Arg Leu Met Ala Gly Gly Cys Leu Pro Gln Pro 
                85                  90                  95      


Glu Gly Thr Ala Trp Ala Leu Asp Leu Pro Gln Gly Thr Leu Gly Pro 
            100                 105                 110         


Arg Asn Ser Leu Cys Ser Ala Leu Leu Glu Ala Arg Leu Pro Arg Asp 
        115                 120                 125             


Ser Leu Gly Ser Ser Ala Ser Ser Ser Ser Met Asp Pro Asp Lys Gly 
    130                 135                 140                 


Ala Leu Pro Gln Pro Ser Pro Ser Arg Leu Arg Pro Lys Arg Ser Trp 
145                 150                 155                 160 


Gly Thr Trp Glu Glu Ala Met Cys Pro Leu Cys Lys Arg Thr Arg Ser 
                165                 170                 175     


Gly Ala Leu Glu Arg Pro 
            180         


<210>  1708
<211>  191
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1708

Xaa Glu Gln Gly Pro Ala Ala Pro Lys Ser Trp Leu Leu Leu Pro Thr 
1               5                   10                  15      


Thr Leu Ala Leu His Gly Ser Leu Asp Ala Val Ser Gln Ala Gln Gly 
            20                  25                  30          


Arg Pro Gly His Pro Asp Ala Pro Pro Asn Ile Tyr Glu Gly Gly Leu 
        35                  40                  45              


Gly Ser Pro Gln Pro Gln Cys Pro Ser Ala Gln Gly Ser Lys Pro Lys 
    50                  55                  60                  


Asn Phe Arg Leu Arg His Leu Arg Gly Leu Gly Leu Tyr Leu Glu Ser 
65                  70                  75                  80  


His Pro Pro Pro Thr Gly Gln Cys Glu Ser His Trp Leu Gly Arg Leu 
                85                  90                  95      


Met Ala Gly Gly Cys Leu Pro Gln Pro Glu Gly Thr Ala Trp Ala Leu 
            100                 105                 110         


Asp Leu Pro Gln Gly Thr Leu Gly Pro Arg Asn Ser Leu Cys Ser Ala 
        115                 120                 125             


Leu Leu Glu Ala Arg Leu Pro Arg Asp Ser Leu Gly Ser Ser Ala Ser 
    130                 135                 140                 


Ser Ser Ser Met Asp Pro Asp Lys Gly Ala Leu Pro Gln Pro Ser Pro 
145                 150                 155                 160 


Ser Arg Leu Arg Pro Lys Arg Ser Trp Gly Thr Trp Glu Glu Ala Met 
                165                 170                 175     


Cys Pro Leu Cys Lys Arg Thr Arg Ser Gly Ala Leu Glu Arg Pro 
            180                 185                 190     


<210>  1709
<211>  90
<212>  PRT
<213>  Homo Sapiens

<400>  1709

Met Lys Thr Leu Pro Val Leu Val Leu Ser Leu Thr Leu Leu Thr Val 
1               5                   10                  15      


Phe Ser Glu Thr Ser Pro Ile Leu Thr Glu Lys Gln Ala Lys Gln Leu 
            20                  25                  30          


Leu Arg Ser Arg Arg Gln Asp Arg Pro Ser Lys Pro Gly Phe Pro Asp 
        35                  40                  45              


Glu Pro Met Arg Glu Tyr Met His His Leu Leu Ala Leu Glu His Arg 
    50                  55                  60                  


Ala Glu Glu Gln Phe Leu Glu His Trp Leu Asn Pro His Cys Lys Pro 
65                  70                  75                  80  


His Cys Asp Arg Asn Arg Ile His Pro Val 
                85                  90  


<210>  1710
<211>  275
<212>  PRT
<213>  Homo Sapiens

<400>  1710

Met Asp Gly Asp Glu Lys Glu Leu Glu Ser Ser Glu Glu Gly Gly Ser 
1               5                   10                  15      


Ala Glu Glu Arg Arg Leu Glu Pro Pro Ser Ser Ser His Tyr Cys Leu 
            20                  25                  30          


Tyr Ser Tyr Arg Gly Ser Arg Leu Ala Gln Gln Arg Gly Asp Ser Glu 
        35                  40                  45              


Asp Gly Ser Pro Ser Gly Thr Asn Ala Glu Thr Pro Ser Gly Asp Asp 
    50                  55                  60                  


Phe Ser Leu Ser Leu Ala Asp Thr Asn Leu Pro Ser Glu Val Glu Pro 
65                  70                  75                  80  


Glu Leu Arg Ser Phe Ile Ala Lys Arg Leu Ser Arg Gly Ala Val Phe 
                85                  90                  95      


Glu Gly Leu Gly Asn Val Ala Ser Val Glu Leu Lys Ile Pro Gly Tyr 
            100                 105                 110         


Arg Val Gly Cys Tyr Tyr Cys Leu Phe Gln Asn Glu Lys Leu Leu Pro 
        115                 120                 125             


Glu Thr Val Thr Ile Asp Ser Glu Arg Asn Pro Ser Glu Tyr Val Val 
    130                 135                 140                 


Cys Phe Leu Gly Gly Ser Glu Lys Gly Leu Glu Leu Phe Arg Leu Glu 
145                 150                 155                 160 


Leu Asp Lys Tyr Ile Gln Gly Leu Lys Asn Asn Met Asn Cys Glu Ala 
                165                 170                 175     


Arg Gly Leu Glu Ser His Ile Lys Ser Tyr Leu Ser Ser Trp Phe Glu 
            180                 185                 190         


Asp Val Val Cys Pro Ile Gln Arg Val Val Leu Leu Phe Gln Glu Lys 
        195                 200                 205             


Leu Thr Phe Leu Leu His Ala Ala Leu Ser Tyr Thr Pro Val Glu Val 
    210                 215                 220                 


Lys Glu Ser Asp Glu Lys Thr Lys Arg Asp Ile Asn Arg Phe Leu Ser 
225                 230                 235                 240 


Val Ala Ser Leu Gln Gly Leu Ile His Glu Gly Thr Met Thr Ser Leu 
                245                 250                 255     


Cys Met Ala Met Thr Glu Glu Gln His Lys Ser Val Val Ile Asp Cys 
            260                 265                 270         


Ser Ser Ser 
        275 


<210>  1711
<211>  75
<212>  PRT
<213>  Homo Sapiens

<400>  1711

Met Leu Pro Ser Leu Gln Glu Ser Met Asp Gly Asp Glu Lys Glu Leu 
1               5                   10                  15      


Glu Ser Ser Glu Glu Gly Gly Ser Ala Glu Glu Arg Arg Leu Glu Pro 
            20                  25                  30          


Pro Ser Ser Ser His Tyr Cys Leu Tyr Ser Tyr Arg Gly Ser Arg Leu 
        35                  40                  45              


Ala Gln Gln Arg Gly Asp Ser Glu Asp Gly Ser Pro Ser Gly Thr Asn 
    50                  55                  60                  


Ala Glu Thr Pro Ser Gly Asp Asp Phe Arg Tyr 
65                  70                  75  


<210>  1712
<211>  396
<212>  PRT
<213>  Homo Sapiens

<400>  1712

Met Leu Pro Ser Leu Gln Glu Ser Met Asp Gly Asp Glu Lys Glu Leu 
1               5                   10                  15      


Glu Ser Ser Glu Glu Gly Gly Ser Ala Glu Glu Arg Arg Leu Glu Pro 
            20                  25                  30          


Pro Ser Ser Ser His Tyr Cys Leu Tyr Ser Tyr Arg Gly Ser Arg Leu 
        35                  40                  45              


Ala Gln Gln Arg Gly Asp Ser Glu Asp Gly Ser Pro Ser Gly Thr Asn 
    50                  55                  60                  


Ala Glu Thr Pro Ser Gly Asp Asp Phe Ser Leu Ser Leu Ala Asp Thr 
65                  70                  75                  80  


Asn Leu Pro Ser Glu Val Glu Pro Glu Leu Arg Ser Phe Ile Ala Lys 
                85                  90                  95      


Arg Leu Ser Arg Gly Ala Val Phe Glu Gly Leu Gly Asn Val Ala Ser 
            100                 105                 110         


Val Glu Leu Lys Ile Pro Gly Tyr Arg Val Gly Cys Tyr Tyr Cys Leu 
        115                 120                 125             


Phe Gln Asn Glu Lys Leu Leu Pro Glu Thr Val Thr Ile Asp Ser Glu 
    130                 135                 140                 


Arg Asn Pro Ser Glu Tyr Val Val Cys Phe Leu Gly Gly Ser Glu Lys 
145                 150                 155                 160 


Gly Leu Glu Leu Phe Arg Leu Glu Leu Asp Lys Tyr Ile Gln Gly Leu 
                165                 170                 175     


Lys Asn Asn Met Asn Cys Glu Ala Arg Gly Leu Glu Ser His Ile Lys 
            180                 185                 190         


Ser Tyr Leu Ser Ser Trp Phe Glu Asp Val Val Cys Pro Ile Gln Arg 
        195                 200                 205             


Val Val Leu Leu Phe Gln Glu Lys Leu Thr Phe Leu Leu His Ala Ala 
    210                 215                 220                 


Leu Ser Tyr Thr Pro Val Glu Val Lys Glu Ser Asp Glu Lys Thr Lys 
225                 230                 235                 240 


Arg Asp Ile Asn Arg Phe Leu Ser Val Ala Ser Leu Gln Gly Leu Ile 
                245                 250                 255     


His Glu Gly Thr Met Thr Ser Leu Cys Met Ala Met Thr Glu Glu Gln 
            260                 265                 270         


His Lys Ser Val Val Ile Asp Cys Ser Ser Ser Gln Pro Gln Phe Cys 
        275                 280                 285             


Asn Ala Gly Ser Asn Arg Phe Cys Glu Asp Trp Met Gln Ala Phe Leu 
    290                 295                 300                 


Asn Gly Ala Lys Gly Gly Asn Pro Phe Leu Phe Arg Gln Val Leu Glu 
305                 310                 315                 320 


Asn Phe Lys Leu Lys Ala Ile Gln Asp Thr Asn Asn Leu Lys Arg Phe 
                325                 330                 335     


Ile Arg Gln Ala Glu Met Asn His Tyr Ala Leu Phe Lys Cys Tyr Met 
            340                 345                 350         


Phe Leu Lys Asn Cys Gly Ser Gly Asp Ile Leu Leu Lys Ile Val Lys 
        355                 360                 365             


Val Glu His Glu Glu Met Pro Glu Ala Lys Asn Val Ile Ala Val Leu 
    370                 375                 380                 


Glu Glu Phe Met Lys Glu Ala Leu Asp Gln Ser Phe 
385                 390                 395     


<210>  1713
<211>  396
<212>  PRT
<213>  Homo Sapiens

<400>  1713

Met Leu Pro Ser Leu Gln Glu Ser Met Asp Gly Asp Glu Lys Glu Leu 
1               5                   10                  15      


Glu Ser Ser Glu Glu Gly Gly Ser Ala Glu Glu Arg Arg Leu Glu Pro 
            20                  25                  30          


Pro Ser Ser Ser His Tyr Cys Leu Tyr Ser Tyr Arg Gly Ser Arg Leu 
        35                  40                  45              


Ala Gln Gln Arg Gly Asp Ser Glu Asp Gly Ser Pro Ser Gly Thr Asn 
    50                  55                  60                  


Ala Glu Thr Pro Ser Gly Asp Asp Phe Ser Leu Ser Leu Ala Asp Thr 
65                  70                  75                  80  


Asn Leu Pro Ser Glu Val Glu Pro Glu Leu Arg Ser Phe Ile Ala Lys 
                85                  90                  95      


Arg Leu Ser Arg Gly Ala Val Phe Glu Gly Leu Gly Asn Val Ala Ser 
            100                 105                 110         


Val Glu Leu Lys Ile Pro Gly Tyr Arg Val Gly Cys Tyr Tyr Cys Leu 
        115                 120                 125             


Phe Gln Asn Glu Lys Leu Leu Pro Glu Thr Val Thr Ile Asp Ser Glu 
    130                 135                 140                 


Arg Asn Pro Ser Glu Tyr Val Val Cys Phe Leu Gly Gly Ser Glu Lys 
145                 150                 155                 160 


Gly Leu Glu Thr Phe Arg Leu Glu Leu Asp Lys Tyr Ile Gln Gly Leu 
                165                 170                 175     


Lys Asn Asn Met Asn Cys Glu Ala Arg Gly Leu Glu Ser His Ile Lys 
            180                 185                 190         


Ser Tyr Leu Ser Ser Trp Phe Glu Asp Val Val Cys Pro Ile Gln Arg 
        195                 200                 205             


Val Val Leu Leu Phe Gln Glu Lys Leu Thr Phe Leu Leu His Ala Ala 
    210                 215                 220                 


Leu Ser Tyr Thr Pro Val Glu Val Lys Glu Ser Asp Glu Lys Thr Lys 
225                 230                 235                 240 


Arg Asp Ile Asn Arg Phe Leu Ser Val Ala Ser Leu Gln Gly Leu Ile 
                245                 250                 255     


His Glu Gly Thr Met Thr Ser Leu Cys Met Ala Met Thr Glu Glu Gln 
            260                 265                 270         


His Lys Ser Val Val Ile Asp Cys Ser Ser Ser Gln Pro Gln Phe Cys 
        275                 280                 285             


Asn Ala Gly Ser Asn Arg Phe Cys Glu Asp Trp Met Gln Ala Phe Leu 
    290                 295                 300                 


Asn Gly Ala Lys Gly Gly Asn Pro Phe Leu Phe Arg Gln Val Leu Glu 
305                 310                 315                 320 


Asn Phe Lys Leu Lys Ala Ile Gln Asp Thr Asn Asn Leu Lys Arg Phe 
                325                 330                 335     


Ile Arg Gln Ala Glu Met Asn His Tyr Ala Leu Phe Lys Cys Tyr Met 
            340                 345                 350         


Phe Leu Lys Asn Cys Gly Ser Gly Asp Ile Leu Leu Lys Ile Val Lys 
        355                 360                 365             


Val Glu His Glu Glu Met Pro Glu Ala Lys Asn Val Ile Ala Val Leu 
    370                 375                 380                 


Glu Glu Phe Met Lys Glu Ala Leu Asp Gln Ser Phe 
385                 390                 395     


<210>  1714
<211>  38
<212>  PRT
<213>  Homo Sapiens

<400>  1714

Met Asn Cys Glu Ala Arg Gly Leu Glu Ser His Ile Lys Ser Tyr Leu 
1               5                   10                  15      


Ser Ser Trp Phe Glu Asp Val Val Cys Pro Ile Gln Arg Val Val Leu 
            20                  25                  30          


Leu Phe Gln Glu Lys Leu 
        35              


<210>  1715
<211>  88
<212>  PRT
<213>  Homo Sapiens

<400>  1715

Met Asn Cys Glu Ala Arg Gly Leu Glu Ser His Ile Lys Ser Tyr Leu 
1               5                   10                  15      


Ser Ser Trp Phe Glu Asp Val Val Cys Pro Ile Gln Arg Val Val Leu 
            20                  25                  30          


Leu Phe Gln Glu Lys Leu Thr Phe Leu Leu His Ala Ala Leu Ser Tyr 
        35                  40                  45              


Thr Pro Val Glu Val Lys Glu Ser Asp Glu Lys Thr Lys Arg Asp Ile 
    50                  55                  60                  


Asn Arg Phe Leu Ser Val Ala Ser Leu Gln Gly Leu Ile His Glu Gly 
65                  70                  75                  80  


Thr Met Thr Ser Leu Cys Met Ala 
                85              


<210>  1716
<211>  132
<212>  PRT
<213>  Homo Sapiens

<400>  1716

Met Asn Cys Glu Ala Arg Gly Leu Glu Ser His Ile Lys Ser Tyr Leu 
1               5                   10                  15      


Ser Ser Trp Phe Glu Asp Val Val Cys Pro Ile Gln Arg Val Val Leu 
            20                  25                  30          


Leu Phe Gln Glu Lys Leu Thr Phe Leu Leu His Ala Ala Leu Ser Tyr 
        35                  40                  45              


Thr Pro Val Glu Val Lys Glu Ser Asp Glu Lys Thr Lys Arg Asp Ile 
    50                  55                  60                  


Asn Arg Phe Leu Ser Val Ala Ser Leu Gln Gly Leu Ile His Glu Gly 
65                  70                  75                  80  


Thr Met Thr Ser Leu Cys Met Ala Met Thr Glu Glu Gln His Lys Ser 
                85                  90                  95      


Val Val Ile Asp Cys Ser Ser Ser Gln Pro Gln Phe Cys Asn Ala Gly 
            100                 105                 110         


Ser Asn Arg Phe Cys Glu Asp Trp Met Gln Ala Phe Leu Asn Gly Ala 
        115                 120                 125             


Lys Gly Gly Asn 
    130         


<210>  1717
<211>  48
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1717

Xaa Ala Met Thr Glu Glu Gln His Lys Ser Val Val Ile Asp Cys Ser 
1               5                   10                  15      


Ser Ser Gln Pro Gln Phe Cys Asn Ala Gly His Thr Arg His Lys Gln 
            20                  25                  30          


Phe Glu Glu Ile Tyr Pro Thr Gly Arg Asn Glu Ser Leu Cys Phe Val 
        35                  40                  45              


<210>  1718
<211>  97
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1718

Xaa Leu Leu Phe Gln Glu Lys Leu Thr Phe Leu Leu His Ala Ala Leu 
1               5                   10                  15      


Ser Tyr Thr Pro Val Glu Val Lys Glu Ser Asp Glu Lys Thr Lys Arg 
            20                  25                  30          


Asp Ile Asn Arg Phe Leu Ser Val Ala Ser Leu Gln Gly Leu Ile His 
        35                  40                  45              


Glu Gly Thr Met Thr Ser Leu Cys Met Ala Met Thr Glu Glu Gln His 
    50                  55                  60                  


Lys Ser Val Val Ile Asp Cys Ser Ser Ser Gln Pro Gln Phe Cys Asn 
65                  70                  75                  80  


Ala Glu Ile Leu Asp Pro Pro Pro Leu Leu Phe Thr Leu Ser His Pro 
                85                  90                  95      


Ser 
    


<210>  1719
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  1719

Leu Ile Ala Leu Thr Ser Leu Thr Ala Ala Ser Ser Phe Ser Lys Ala 
1               5                   10                  15      


Arg Glu Glu Glu Ile Thr Pro Val Val Ser Ile Ala Tyr Lys Val Leu 
            20                  25                  30          


Glu Val Phe Pro Lys Gly Arg Trp Val Leu Ile Thr Cys Cys Ala Pro 
        35                  40                  45              


Gln Pro Pro Pro Pro Ile Thr Tyr Ser Leu Cys Gly Thr Lys Asn Ile 
    50                  55                  60                  


Lys Val Ala Lys Lys Val Val Lys Thr His Glu Pro Ala Ser Phe Asn 
65                  70                  75                  80  


Leu Asn Val Thr Leu Lys Ser Ser Pro Asp Leu Leu Thr Tyr Phe Cys 
                85                  90                  95      


Trp Ala Ser Ser Thr Ser Gly Ala His Val Asp Ser Ala Arg Leu Gln 
            100                 105                 110         


Met His Trp Glu Leu Trp Ser Lys Pro Val Ser Glu Leu Arg Ala Asn 
        115                 120                 125             


Phe Thr Leu Gln Asp Arg Gly Ala Gly Pro Arg Val Glu Met Ile Cys 
    130                 135                 140                 


Gln Ala Ser Ser Gly Ser Pro Pro Ile Thr Asn Ser Leu Ile Gly Lys 
145                 150                 155                 160 


Asp Gly Gln Val His Leu Gln Gln Arg Pro Cys His Arg Gln Pro Ala 
                165                 170                 175     


Asn Phe Ser Phe Leu Pro Ser Gln Thr Ser Asp Trp Phe 
            180                 185                 


<210>  1720
<211>  265
<212>  PRT
<213>  Homo Sapiens

<400>  1720

Met Gly Leu Pro Gly Leu Phe Cys Leu Ala Val Leu Ala Ala Ser Ser 
1               5                   10                  15      


Phe Ser Lys Ala Arg Glu Glu Glu Ile Thr Pro Val Val Ser Ile Ala 
            20                  25                  30          


Tyr Lys Val Leu Glu Val Phe Pro Lys Gly Arg Trp Val Leu Ile Thr 
        35                  40                  45              


Cys Cys Ala Pro Gln Pro Pro Pro Pro Ile Thr Tyr Ser Leu Cys Gly 
    50                  55                  60                  


Thr Lys Asn Ile Lys Val Ala Lys Lys Val Val Lys Thr His Glu Pro 
65                  70                  75                  80  


Ala Ser Phe Asn Leu Asn Val Thr Leu Lys Ser Ser Pro Asp Leu Leu 
                85                  90                  95      


Thr Tyr Phe Cys Trp Ala Ser Ser Thr Ser Gly Ala His Val Asp Ser 
            100                 105                 110         


Ala Arg Leu Gln Met His Trp Glu Leu Trp Ser Lys Pro Val Ser Glu 
        115                 120                 125             


Leu Arg Ala Asn Phe Thr Leu Gln Asp Arg Gly Ala Gly Pro Arg Val 
    130                 135                 140                 


Glu Met Ile Cys Gln Ala Ser Ser Gly Ser Pro Pro Ile Thr Asn Ser 
145                 150                 155                 160 


Leu Ile Gly Lys Asp Gly Gln Val His Leu Gln Gln Arg Pro Cys His 
                165                 170                 175     


Arg Gln Pro Ala Asn Phe Ser Phe Leu Pro Ser Gln Thr Ser Asp Trp 
            180                 185                 190         


Phe Trp Cys Gln Ala Ala Asn Asn Ala Asn Val Gln His Ser Ala Leu 
        195                 200                 205             


Thr Val Val Pro Pro Gly Gly Asp Gln Lys Met Glu Asp Trp Gln Gly 
    210                 215                 220                 


Pro Leu Glu Ser Pro Ile Leu Ala Leu Pro Leu Tyr Arg Ser Thr Arg 
225                 230                 235                 240 


Arg Leu Ser Glu Glu Glu Phe Gly Gly Phe Arg Ile Gly Asn Gly Glu 
                245                 250                 255     


Val Arg Gly Arg Lys Ala Ala Ala Met 
            260                 265 


<210>  1721
<211>  151
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1721

Xaa Gln Pro Pro Pro Pro Ile Thr Tyr Ser Leu Cys Gly Thr Lys Asn 
1               5                   10                  15      


Ile Lys Val Ala Lys Lys Val Val Lys Thr His Glu Pro Ala Ser Phe 
            20                  25                  30          


Asn Leu Asn Val Thr Leu Lys Ser Ser Pro Asp Leu Leu Thr Tyr Phe 
        35                  40                  45              


Cys Trp Ala Ser Ser Thr Ser Gly Ala His Val Asp Ser Ala Arg Leu 
    50                  55                  60                  


Gln Met His Trp Glu Leu Trp Ser Arg Gln Arg Gly Arg Pro Gln Gly 
65                  70                  75                  80  


Gly Asp Asp Leu Pro Gly Val Leu Gly Gln Pro Thr Tyr His Gln Gln 
                85                  90                  95      


Pro Asp Arg Glu Gly Trp Ala Gly Pro Pro Ala Ala Glu Thr Met Pro 
            100                 105                 110         


Gln Ala Ala Cys Gln Leu Leu Leu Pro Ala Glu Pro Asp Ile Gly Leu 
        115                 120                 125             


Val Leu Val Pro Gly Cys Lys Gln Arg Gln Cys Pro Ala Gln Arg Pro 
    130                 135                 140                 


His Ser Gly Ala Pro Arg Trp 
145                 150     


<210>  1722
<211>  35
<212>  PRT
<213>  Homo Sapiens

<400>  1722

Glu Ser Met Ile Pro Ile Thr Arg Ser Leu Gln Lys Ala Leu His His 
1               5                   10                  15      


Leu Ser Arg Leu Arg Asp Leu Val Asp Asp Thr Asn Gly Glu Arg Ser 
            20                  25                  30          


Pro Lys Met 
        35  


<210>  1723
<211>  372
<212>  PRT
<213>  Homo Sapiens

<400>  1723

Met Ala Lys Ser Lys Thr Lys His Arg Leu Cys Ser Gln Glu Ser Ser 
1               5                   10                  15      


Val Ser Ala Leu Leu Ala Ser Cys Thr Leu Ser Gly Ser Asn Ser Ser 
            20                  25                  30          


Asn Ser Asp Gly Ser Phe His Tyr Lys Asp Lys Leu Tyr Arg Ser Ala 
        35                  40                  45              


Ser Gln Ala Leu Gln Ala Tyr Ile Asp Asp Phe Asp Leu Gly Gln Ile 
    50                  55                  60                  


Tyr Pro Gly Ala Ser Thr Gly Lys Ile Asn Ile Asp Glu Asp Phe Thr 
65                  70                  75                  80  


Asn Met Ser Gln Phe Cys Asn Tyr Ile Tyr Lys Pro Asn Asn Ala Phe 
                85                  90                  95      


Glu Asn Leu Asp His Lys Lys His Ser Asn Phe Ile Ser Cys Arg Arg 
            100                 105                 110         


His Thr Val Asn Asp Ile Asp Ser Met Ser Leu Thr Thr Asp Asp Leu 
        115                 120                 125             


Leu Arg Leu Pro Ala Asp Gly Ser Phe Ser Tyr Thr Tyr Val Gly Pro 
    130                 135                 140                 


Ser His Arg Thr Ser Lys Lys Asn Lys Lys Cys Arg Gly Arg Leu Gly 
145                 150                 155                 160 


Ser Leu Asp Ile Glu Lys Asn Pro His Phe Gln Gly Pro Tyr Thr Ser 
                165                 170                 175     


Met Gly Lys Asp Asn Phe Val Thr Pro Val Ile Arg Ser Asn Ile Asn 
            180                 185                 190         


Gly Lys Gln Cys Gly Asp Lys Ile Glu Leu Leu Ile Leu Lys Ala Lys 
        195                 200                 205             


Arg Asn Leu Glu Gln Cys Thr Glu Glu Leu Pro Lys Ser Met Lys Lys 
    210                 215                 220                 


Asp Asp Ser Pro Cys Ser Leu Asp Lys Leu Glu Ala Asp Arg Ser Trp 
225                 230                 235                 240 


Glu Asn Ile Pro Val Thr Phe Lys Ser Pro Val Pro Val Asn Ser Asp 
                245                 250                 255     


Asp Ser Pro Gln Gln Thr Ser Arg Ala Lys Ser Ala Lys Gly Val Leu 
            260                 265                 270         


Glu Asp Phe Leu Asn Asn Asp Asn Gln Ser Cys Thr Leu Ser Gly Gly 
        275                 280                 285             


Lys His His Gly Pro Val Glu Ala Leu Lys Gln Met Leu Phe Asn Leu 
    290                 295                 300                 


Gln Ala Val Gln Glu Arg Phe Asn Gln Asn Lys Thr Thr Asp Pro Lys 
305                 310                 315                 320 


Glu Glu Ile Lys Gln Val Ser Glu Asp Asp Phe Ser Lys Leu Gln Leu 
                325                 330                 335     


Lys Glu Ser Met Ile Pro Ile Thr Arg Ser Leu Gln Lys Ala Leu His 
            340                 345                 350         


His Leu Ser Arg Leu Arg Asp Leu Val Asp Asp Thr Asn Gly Glu Arg 
        355                 360                 365             


Ser Pro Lys Met 
    370         


<210>  1724
<211>  533
<212>  PRT
<213>  Homo Sapiens

<400>  1724

Met Ala Lys Ser Lys Thr Lys His Arg Leu Cys Ser Gln Glu Ser Ser 
1               5                   10                  15      


Val Ser Ala Leu Leu Ala Ser Cys Thr Leu Ser Gly Ser Asn Ser Ser 
            20                  25                  30          


Asn Ser Asp Gly Ser Phe His Tyr Lys Asp Lys Leu Tyr Arg Ser Ala 
        35                  40                  45              


Ser Gln Ala Leu Gln Ala Tyr Ile Asp Asp Phe Asp Leu Gly Gln Ile 
    50                  55                  60                  


Tyr Pro Gly Ala Ser Thr Gly Lys Ile Asn Ile Asp Glu Asp Phe Thr 
65                  70                  75                  80  


Asn Met Ser Gln Phe Cys Asn Tyr Ile Tyr Lys Pro Asn Asn Ala Phe 
                85                  90                  95      


Glu Asn Leu Asp His Lys Lys His Ser Asn Phe Ile Ser Cys Arg Arg 
            100                 105                 110         


His Thr Val Asn Asp Ile Asp Ser Met Ser Leu Thr Thr Asp Asp Leu 
        115                 120                 125             


Leu Arg Leu Pro Ala Asp Gly Ser Phe Ser Tyr Thr Tyr Val Gly Pro 
    130                 135                 140                 


Ser His Arg Thr Ser Lys Lys Asn Lys Lys Cys Arg Gly Arg Leu Gly 
145                 150                 155                 160 


Ser Leu Asp Ile Glu Lys Asn Pro His Phe Gln Gly Pro Tyr Thr Ser 
                165                 170                 175     


Met Gly Lys Asp Asn Phe Val Thr Pro Val Ile Arg Ser Asn Ile Asn 
            180                 185                 190         


Gly Lys Gln Cys Gly Arg Leu Lys Asn Pro Lys Leu Met Asn Arg Thr 
        195                 200                 205             


Asn Asn Cys Ile Ser Glu Ser Ser Leu Ser Phe Pro Lys Lys Ser Ser 
    210                 215                 220                 


Phe Lys Asp Ser Ser Glu His Ser Leu Glu Lys Asn Tyr Pro Arg Trp 
225                 230                 235                 240 


Leu Thr Ser Gln Lys Ser Asp Leu Asn Val Ser Gly Ile Thr Ser Ile 
                245                 250                 255     


Pro Asp Phe Lys Tyr Pro Val Trp Leu His Asn Gln Asp Leu Leu Pro 
            260                 265                 270         


Asp Ala Asn Ser Gln Arg Val Tyr Gln Ile Phe Lys Asp Asp Gln Cys 
        275                 280                 285             


Ser Pro Arg His Ser His Gln Ala Gln Gly Thr Ser Arg Leu Ile Asn 
    290                 295                 300                 


Lys Leu Asp Cys Phe Glu Tyr Ala Phe Glu Pro Ser Asn Phe Ser Asn 
305                 310                 315                 320 


Ser Leu Ser Asp Asp Lys Glu Leu Val Asn Glu Tyr Lys Cys Asp Phe 
                325                 330                 335     


Glu His Ser Gln Cys Gln Cys Glu Asn Pro Leu Leu Pro Gly Gln Ser 
            340                 345                 350         


Thr Lys Pro Phe Ser Gly Asp Lys Ile Glu Leu Leu Ile Leu Lys Ala 
        355                 360                 365             


Lys Arg Asn Leu Glu Gln Cys Thr Glu Glu Leu Pro Lys Ser Met Lys 
    370                 375                 380                 


Lys Asp Asp Ser Pro Cys Ser Leu Asp Lys Leu Glu Ala Asp Arg Ser 
385                 390                 395                 400 


Trp Glu Asn Ile Pro Val Thr Phe Lys Ser Pro Val Pro Val Asn Ser 
                405                 410                 415     


Asp Asp Ser Pro Gln Gln Thr Ser Arg Ala Lys Ser Ala Lys Gly Val 
            420                 425                 430         


Leu Glu Asp Phe Leu Asn Asn Asp Asn Gln Ser Cys Thr Leu Ser Gly 
        435                 440                 445             


Gly Lys His His Gly Pro Val Glu Ala Leu Lys Gln Met Leu Phe Asn 
    450                 455                 460                 


Leu Gln Ala Val Gln Glu Arg Phe Asn Gln Asn Lys Thr Thr Asp Pro 
465                 470                 475                 480 


Lys Glu Glu Ile Lys Gln Val Ser Glu Asp Asp Phe Ser Lys Leu Gln 
                485                 490                 495     


Leu Lys Glu Ser Met Ile Pro Ile Thr Arg Ser Leu Gln Lys Ala Leu 
            500                 505                 510         


His His Leu Ser Arg Leu Arg Asp Leu Val Asp Asp Thr Asn Gly Glu 
        515                 520                 525             


Arg Ser Pro Lys Met 
    530             


<210>  1725
<211>  533
<212>  PRT
<213>  Homo Sapiens

<400>  1725

Met Ala Lys Ser Lys Thr Lys His Arg Leu Cys Ser Gln Glu Ser Ser 
1               5                   10                  15      


Val Ser Ala Leu Leu Ala Ser Cys Thr Leu Ser Gly Ser Asn Ser Ser 
            20                  25                  30          


Asn Ser Asp Gly Ser Phe His Tyr Lys Asp Lys Leu Tyr Arg Ser Ala 
        35                  40                  45              


Ser Gln Ala Leu Gln Ala Tyr Ile Asp Asp Phe Asp Leu Gly Gln Ile 
    50                  55                  60                  


Tyr Pro Gly Ala Ser Thr Gly Lys Ile Asn Ile Asp Glu Asp Phe Thr 
65                  70                  75                  80  


Asn Met Ser Gln Phe Cys Asn Tyr Ile Tyr Lys Pro Asn Asn Ala Phe 
                85                  90                  95      


Glu Asn Leu Asp His Lys Lys His Ser Asn Phe Ile Ser Cys Arg Arg 
            100                 105                 110         


His Thr Val Asn Asp Ile Asp Ser Met Ser Leu Thr Thr Asp Asp Leu 
        115                 120                 125             


Leu Arg Leu Pro Ala Asp Gly Ser Phe Ser Tyr Thr Tyr Val Gly Pro 
    130                 135                 140                 


Ser His Arg Thr Ser Lys Lys Asn Lys Lys Cys Arg Gly Arg Leu Gly 
145                 150                 155                 160 


Ser Leu Asp Ile Glu Lys Asn Pro His Phe Gln Gly Pro Tyr Thr Ser 
                165                 170                 175     


Met Gly Lys Asp Asn Phe Val Thr Pro Val Ile Arg Ser Asn Ile Asn 
            180                 185                 190         


Gly Lys Gln Cys Gly Arg Leu Lys Asn Pro Lys Leu Met Asn Arg Thr 
        195                 200                 205             


Asn Asn Cys Ile Ser Glu Ser Ser Leu Ser Phe Pro Lys Lys Ser Ser 
    210                 215                 220                 


Phe Lys Asp Ser Ser Glu His Ser Leu Glu Lys Asn Tyr Pro Arg Trp 
225                 230                 235                 240 


Leu Thr Ser Gln Lys Ser Asp Leu Asn Val Ser Gly Ile Thr Ser Ile 
                245                 250                 255     


Pro Asp Phe Lys Tyr Pro Val Trp Leu His Asn Gln Asp Leu Leu Pro 
            260                 265                 270         


Asp Ala Asn Ser Gln Arg Val Tyr Gln Ile Phe Lys Asp Asp Gln Cys 
        275                 280                 285             


Ser Pro Arg His Ser His Gln Ala Gln Gly Thr Ser Arg Leu Ile Asn 
    290                 295                 300                 


Lys Leu Asp Cys Phe Glu Tyr Ala Phe Glu Pro Ser Asn Phe Ser Asn 
305                 310                 315                 320 


Ser Leu Ser Asp Asp Lys Glu Leu Val Asn Glu Tyr Lys Cys Asp Phe 
                325                 330                 335     


Glu His Ser Gln Cys Gln Cys Glu Asn Pro Leu Leu Pro Gly Gln Ser 
            340                 345                 350         


Thr Lys Pro Phe Ser Gly Asp Lys Ile Glu Leu Leu Ile Leu Lys Ala 
        355                 360                 365             


Lys Arg Asn Leu Glu Gln Cys Thr Glu Glu Leu Pro Lys Ser Met Lys 
    370                 375                 380                 


Lys Asp Asp Ser Pro Cys Ser Leu Asp Lys Leu Glu Ala Asp Arg Ser 
385                 390                 395                 400 


Trp Glu Asn Ile Pro Val Thr Phe Lys Ser Pro Val Pro Val Asn Ser 
                405                 410                 415     


Asp Asp Ser Pro Gln Gln Thr Ser Arg Ala Lys Ser Ala Lys Gly Val 
            420                 425                 430         


Leu Glu Asp Phe Leu Asn Asn Asp Asn Gln Ser Cys Thr Leu Ser Gly 
        435                 440                 445             


Gly Lys His His Gly Pro Val Glu Ala Leu Lys Gln Met Leu Phe Asn 
    450                 455                 460                 


Leu Gln Ala Val Gln Glu Arg Phe Asn Gln Asn Lys Thr Thr Asp Pro 
465                 470                 475                 480 


Lys Glu Glu Ile Lys Gln Val Ser Glu Asp Asp Phe Ser Lys Leu Gln 
                485                 490                 495     


Leu Lys Glu Ser Met Ile Pro Ile Thr Arg Ser Leu Gln Lys Ala Leu 
            500                 505                 510         


His His Leu Ser Arg Leu Arg Asp Leu Val Asp Asp Thr Asn Gly Glu 
        515                 520                 525             


Arg Ser Pro Lys Met 
    530             


<210>  1726
<211>  151
<212>  PRT
<213>  Homo Sapiens

<400>  1726

Met Lys Lys Asp Asp Ser Pro Cys Ser Leu Asp Lys Leu Glu Ala Asp 
1               5                   10                  15      


Arg Ser Trp Glu Asn Ile Pro Val Thr Phe Lys Ser Pro Val Pro Val 
            20                  25                  30          


Asn Ser Asp Asp Ser Pro Gln Gln Thr Ser Arg Ala Lys Ser Ala Lys 
        35                  40                  45              


Gly Val Leu Glu Asp Phe Leu Asn Asn Asp Asn Gln Ser Cys Thr Leu 
    50                  55                  60                  


Ser Gly Gly Lys His His Gly Pro Val Glu Ala Leu Lys Gln Met Leu 
65                  70                  75                  80  


Phe Asn Leu Gln Ala Val Gln Glu Arg Phe Asn Gln Asn Lys Thr Thr 
                85                  90                  95      


Asp Pro Lys Glu Glu Ile Lys Gln Val Ser Glu Asp Asp Phe Ser Lys 
            100                 105                 110         


Leu Gln Leu Lys Glu Ser Met Ile Pro Ile Thr Arg Ser Leu Gln Lys 
        115                 120                 125             


Ala Leu His His Leu Ser Arg Leu Arg Asp Leu Val Asp Asp Thr Asn 
    130                 135                 140                 


Gly Glu Arg Ser Pro Lys Met 
145                 150     


<210>  1727
<211>  142
<212>  PRT
<213>  Homo Sapiens

<400>  1727

Met Phe Val Asp Asn Arg Ile Gln Lys Ser Met Leu Leu Asp Leu Asn 
1               5                   10                  15      


Lys Glu Ile Met Asn Glu Leu Gly Val Thr Val Val Gly Asp Ile Ile 
            20                  25                  30          


Ala Ile Leu Lys His Ala Lys Val Val His Arg Gln Asp Met Cys Lys 
        35                  40                  45              


Ala Ala Thr Glu Ser Val Pro Cys Ser Pro Ser Pro Leu Ala Gly Glu 
    50                  55                  60                  


Ile Arg Arg Gly Thr Ser Ala Ala Ser Arg Met Ile Thr Asn Ser Leu 
65                  70                  75                  80  


Asn His Asp Ser Pro Pro Ser Thr Pro Pro Arg Arg Pro Asp Thr Ser 
                85                  90                  95      


Thr Ser Lys Ile Ser Val Thr Val Ser Asn Lys Met Ala Ala Lys Ser 
            100                 105                 110         


Ala Lys Ala Thr Ala Ala Leu Ala Arg Arg Glu Glu Glu Ser Leu Ala 
        115                 120                 125             


Val Pro Ala Lys Arg Arg Arg Val Thr Ala Glu Met Glu Gly 
    130                 135                 140         


<210>  1728
<211>  355
<212>  PRT
<213>  Homo Sapiens

<400>  1728

Met Phe Val Asp Asn Arg Ile Gln Lys Ser Met Leu Leu Asp Leu Asn 
1               5                   10                  15      


Lys Glu Ile Met Asn Glu Leu Gly Val Thr Val Val Gly Asp Ile Ile 
            20                  25                  30          


Ala Ile Leu Lys His Ala Lys Val Val His Arg Gln Asp Met Cys Lys 
        35                  40                  45              


Ala Ala Thr Glu Ser Val Pro Cys Ser Pro Ser Pro Leu Ala Gly Glu 
    50                  55                  60                  


Ile Arg Arg Gly Thr Ser Ala Ala Ser Arg Met Ile Thr Asn Ser Leu 
65                  70                  75                  80  


Asn His Asp Ser Pro Pro Ser Thr Pro Pro Arg Arg Pro Asp Thr Ser 
                85                  90                  95      


Thr Ser Lys Ile Ser Val Thr Val Ser Asn Lys Met Ala Ala Lys Ser 
            100                 105                 110         


Ala Lys Ala Thr Ala Ala Leu Ala Arg Arg Glu Glu Glu Ser Leu Ala 
        115                 120                 125             


Val Pro Ala Lys Arg Arg Arg Val Thr Ala Glu Met Glu Gly Lys Tyr 
    130                 135                 140                 


Val Ile Asn Met Pro Lys Gly Thr Thr Pro Arg Thr Arg Lys Ile Leu 
145                 150                 155                 160 


Glu Gln Gln Gln Ala Ala Lys Gly Leu His Arg Thr Ser Val Phe Asp 
                165                 170                 175     


Arg Leu Gly Ala Glu Thr Lys Ala Asp Thr Thr Thr Gly Ser Lys Pro 
            180                 185                 190         


Thr Gly Val Phe Ser Arg Leu Gly Ala Thr Pro Glu Thr Asp Glu Asp 
        195                 200                 205             


Leu Ala Trp Asp Ser Asp Asn Asp Ser Ser Ser Ser Val Leu Gln Tyr 
    210                 215                 220                 


Ala Gly Val Leu Lys Lys Leu Gly Arg Gly Pro Ala Lys Ala Ser Pro 
225                 230                 235                 240 


Gln Pro Ala Leu Thr Val Lys Ala Lys Ala Thr Ser Ser Ala Thr Thr 
                245                 250                 255     


Ala Ala Ala Pro Thr Leu Arg Arg Leu Ala Leu Ser Ser Arg Ser Gly 
            260                 265                 270         


Leu Glu Arg Lys Pro Glu Ser Leu Ser Lys Val Ser Ile Ile Lys Arg 
        275                 280                 285             


Leu Gly Ala Ala Ala Leu Val Pro Glu Ala Gln Asp Ser Gln Val Thr 
    290                 295                 300                 


Ser Thr Lys Ser Lys Ser Ser Ala Glu Val Lys Val Thr Ile Lys Arg 
305                 310                 315                 320 


Thr Leu Val Gly Pro Arg Gly Ser Ser Ser Ser Glu Gly Leu Gly Ala 
                325                 330                 335     


Gln Met Asp His Ala Gly Thr Val Ser Val Phe Lys Arg Leu Gly Arg 
            340                 345                 350         


Arg Thr Phe 
        355 


<210>  1729
<211>  422
<212>  PRT
<213>  Homo Sapiens

<400>  1729

Met Val Met Ala Ala Leu Ser Leu Val Ala Ala Cys Trp Gly Arg Ala 
1               5                   10                  15      


Ala Ala Asp Glu Ser Val Gln Leu Pro Ala Ala Pro Gly Ser Ser Val 
            20                  25                  30          


Arg Ala Arg Glu Thr Met Val Ser Val Thr Met Ala Thr Ser Glu Trp 
        35                  40                  45              


Ile Gln Phe Phe Lys Glu Ala Gly Ile Pro Pro Gly Pro Ala Val Asn 
    50                  55                  60                  


Tyr Ala Val Met Phe Val Asp Asn Arg Ile Gln Lys Ser Met Leu Leu 
65                  70                  75                  80  


Asp Leu Asn Lys Glu Ile Met Asn Glu Leu Gly Val Thr Val Val Gly 
                85                  90                  95      


Asp Ile Ile Ala Ile Leu Lys His Ala Lys Val Val His Arg Gln Asp 
            100                 105                 110         


Met Cys Lys Ala Ala Thr Glu Ser Val Pro Cys Ser Pro Ser Pro Leu 
        115                 120                 125             


Ala Gly Glu Ile Arg Arg Gly Thr Ser Ala Ala Ser Arg Met Ile Thr 
    130                 135                 140                 


Asn Ser Leu Asn His Asp Ser Pro Pro Ser Thr Pro Pro Arg Arg Pro 
145                 150                 155                 160 


Asp Thr Ser Thr Ser Lys Ile Ser Val Thr Val Ser Asn Lys Met Ala 
                165                 170                 175     


Ala Lys Ser Ala Lys Ala Thr Ala Ala Leu Ala Arg Arg Glu Glu Glu 
            180                 185                 190         


Ser Leu Ala Val Pro Ala Lys Arg Arg Arg Val Thr Ala Glu Met Glu 
        195                 200                 205             


Gly Lys Tyr Val Ile Asn Met Pro Lys Gly Thr Thr Pro Arg Thr Arg 
    210                 215                 220                 


Lys Ile Leu Glu Gln Gln Gln Ala Ala Lys Gly Leu His Arg Thr Ser 
225                 230                 235                 240 


Val Phe Asp Arg Leu Gly Ala Glu Thr Lys Ala Asp Thr Thr Thr Gly 
                245                 250                 255     


Ser Lys Pro Thr Gly Val Phe Ser Arg Leu Gly Ala Thr Pro Glu Thr 
            260                 265                 270         


Asp Glu Asp Leu Ala Trp Asp Ser Asp Asn Asp Ser Ser Ser Ser Val 
        275                 280                 285             


Leu Gln Tyr Ala Gly Val Leu Lys Lys Leu Gly Arg Gly Pro Ala Lys 
    290                 295                 300                 


Ala Ser Pro Gln Pro Ala Leu Thr Val Lys Ala Lys Ala Thr Ser Ser 
305                 310                 315                 320 


Ala Thr Thr Ala Ala Ala Pro Thr Leu Arg Arg Leu Ala Leu Ser Ser 
                325                 330                 335     


Arg Ser Gly Leu Glu Arg Lys Pro Glu Ser Leu Ser Lys Val Ser Ile 
            340                 345                 350         


Ile Lys Arg Leu Gly Ala Ala Ala Leu Val Pro Glu Ala Gln Asp Ser 
        355                 360                 365             


Gln Val Thr Ser Thr Lys Ser Lys Ser Ser Ala Glu Val Lys Val Thr 
    370                 375                 380                 


Ile Lys Arg Thr Leu Val Gly Pro Arg Gly Ser Ser Ser Ser Glu Gly 
385                 390                 395                 400 


Leu Gly Ala Gln Met Asp His Ala Gly Thr Val Ser Val Phe Lys Arg 
                405                 410                 415     


Leu Gly Arg Arg Thr Phe 
            420         


<210>  1730
<211>  141
<212>  PRT
<213>  Homo Sapiens

<400>  1730

Met Val Met Ala Ala Leu Ser Leu Val Ala Ala Cys Trp Gly Arg Ala 
1               5                   10                  15      


Ala Ala Asp Glu Ser Val Gln Leu Pro Ala Ala Pro Gly Ser Ser Val 
            20                  25                  30          


Arg Ala Arg Glu Thr Met Val Ser Val Thr Met Ala Thr Ser Glu Trp 
        35                  40                  45              


Ile Gln Phe Phe Lys Glu Ala Gly Ile Pro Pro Gly Pro Ala Val Asn 
    50                  55                  60                  


Tyr Ala Val Met Phe Val Asp Asn Arg Ile Gln Lys Ser Met Leu Leu 
65                  70                  75                  80  


Asp Leu Asn Lys Glu Ile Met Asn Glu Leu Gly Val Thr Val Val Gly 
                85                  90                  95      


Asp Ile Ile Ala Ile Leu Lys His Ala Lys Val Val His Arg Gln Gly 
            100                 105                 110         


Leu Thr Pro Ser Pro Arg Leu Glu Cys Ser Ser Thr Ile Ser Ala His 
        115                 120                 125             


Cys Asn Leu Cys Leu Pro Gly His Val Gln Ser Cys His 
    130                 135                 140     


<210>  1731
<211>  146
<212>  PRT
<213>  Homo Sapiens

<400>  1731

Met Val Ser Val Thr Met Ala Thr Ser Glu Trp Ile Gln Phe Phe Lys 
1               5                   10                  15      


Glu Ala Gly Ile Pro Pro Gly Pro Ala Val Asn Tyr Ala Val Met Phe 
            20                  25                  30          


Val Asp Asn Arg Ile Gln Lys Ser Met Leu Leu Asp Leu Asn Lys Glu 
        35                  40                  45              


Ile Met Asn Glu Leu Gly Val Thr Val Val Gly Asp Ile Ile Ala Ile 
    50                  55                  60                  


Leu Lys His Ala Lys Val Val His Arg Gln Asp Met Cys Lys Ala Ala 
65                  70                  75                  80  


Thr Glu Ser Val Pro Cys Ser Pro Ser Pro Leu Ala Gly Glu Ile Arg 
                85                  90                  95      


Arg Gly Thr Ser Ala Ala Ser Arg Met Ile Thr Asn Ser Leu Asn His 
            100                 105                 110         


Asp Ser Pro Pro Ser Thr Pro Pro Arg Arg Pro Asp Thr Ser Thr Ser 
        115                 120                 125             


Lys Ile Ser Val Thr Val Ser Asn Lys Met Ala Ala Lys Ser Ala Lys 
    130                 135                 140                 


Ala Thr 
145     


<210>  1732
<211>  168
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1732

Xaa Glu Met Glu Gly Lys Tyr Val Ile Asn Met Pro Lys Gly Thr Thr 
1               5                   10                  15      


Pro Arg Thr Arg Lys Ile Leu Glu Gln Gln Gln Ala Ala Lys Gly Leu 
            20                  25                  30          


His Arg Thr Ser Val Phe Asp Arg Leu Gly Ala Glu Thr Lys Ala Asp 
        35                  40                  45              


Thr Thr Thr Gly Ser Lys Pro Thr Gly Val Phe Ser Arg Leu Gly Ala 
    50                  55                  60                  


Thr Pro Glu Thr Asp Glu Asp Leu Ala Trp Asp Ser Asp Asn Asp Ser 
65                  70                  75                  80  


Ser Ser Ser Val Leu Gln Tyr Ala Gly Val Leu Lys Lys Leu Gly Arg 
                85                  90                  95      


Gly Pro Ala Lys Ala Ser Pro Gln Pro Ala Leu Thr Val Lys Ala Lys 
            100                 105                 110         


Ala Thr Ser Ser Ala Thr Thr Ala Ala Ala Pro Thr Leu Arg Arg Leu 
        115                 120                 125             


Ala Leu Ser Ser Arg Ser Gly Leu Glu Arg Lys Pro Glu Ser Leu Ser 
    130                 135                 140                 


Lys Val Ser Ile Ile Lys Arg Leu Gly Ala Ala Ala Leu Val Pro Glu 
145                 150                 155                 160 


Ala Gln Asp Ser Gln Ala Ser Ala 
                165             


<210>  1733
<211>  146
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1733

Xaa Gly Ser Ser Val Arg Ala Arg Glu Thr Met Val Ser Val Thr Met 
1               5                   10                  15      


Ala Thr Ser Glu Trp Ile Gln Phe Phe Lys Glu Ala Gly Ile Pro Pro 
            20                  25                  30          


Gly Pro Ala Val Asn Tyr Ala Val Met Phe Val Asp Asn Arg Ile Gln 
        35                  40                  45              


Lys Ser Met Leu Leu Asp Leu Asn Lys Glu Ile Met Asn Glu Leu Gly 
    50                  55                  60                  


Val Thr Val Val Gly Asp Ile Ile Ala Ile Leu Lys His Ala Lys Val 
65                  70                  75                  80  


Val His Arg Gln Asp Met Cys Lys Ala Ala Thr Glu Ser Val Pro Cys 
                85                  90                  95      


Ser Pro Ser Pro Leu Ala Gly Glu Ile Arg Arg Gly Thr Ser Asp Gly 
            100                 105                 110         


Val Ser Leu Cys Cys Pro Gly Trp Ser Thr Val Ala Arg Pro Trp Leu 
        115                 120                 125             


Ser Ala Thr Ser Ala Ser Arg Val Gln Ala Val Leu Leu Pro Gln Pro 
    130                 135                 140                 


Pro Glu 
145     


<210>  1734
<211>  133
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1734

Xaa Thr Asp Glu Asp Leu Ala Trp Asp Ser Asp Asn Asp Ser Ser Ser 
1               5                   10                  15      


Ser Val Leu Gln Tyr Ala Gly Val Leu Lys Lys Leu Gly Arg Gly Pro 
            20                  25                  30          


Ala Lys Ala Ser Pro Gln Pro Ala Leu Thr Val Lys Ala Lys Ala Thr 
        35                  40                  45              


Ser Ser Ala Thr Thr Ala Ala Ala Pro Thr Leu Arg Arg Leu Ala Leu 
    50                  55                  60                  


Ser Ser Arg Ser Gly Leu Glu Arg Lys Pro Glu Ser Leu Ser Lys Val 
65                  70                  75                  80  


Ser Ile Ile Lys Arg Leu Gly Ala Ala Ala Leu Val Pro Glu Ala Gln 
                85                  90                  95      


Asp Ser Gln Val Thr Ser Thr Lys Ser Pro Thr Val Arg Cys Val Leu 
            100                 105                 110         


Pro Asp Pro Pro Val Pro Pro Ala Ser Gln Arg Pro Pro Arg Arg Arg 
        115                 120                 125             


Trp Arg Arg Ala Cys 
    130             


<210>  1735
<211>  110
<212>  PRT
<213>  Homo Sapiens

<400>  1735

Met Arg Ser Glu Cys Val Leu Gly Ala Ala Ser Asp Ser Gly Gln Glu 
1               5                   10                  15      


Ala Pro Arg Asp Thr Trp Phe Leu Gln Gly Trp Lys Ala Ser Arg Arg 
            20                  25                  30          


Phe Leu Ile Lys Gly Ser Val Ala Gly Gly Ala Val Tyr Leu Val Tyr 
        35                  40                  45              


Asp Gln Glu Leu Leu Gly Pro Ser Asp Lys Ser Gln Ala Ala Leu Gln 
    50                  55                  60                  


Lys Ala Gly Glu Val Val Pro Pro Ala Met Tyr Gln Phe Ser Gln Tyr 
65                  70                  75                  80  


Val Cys Gln Gln Thr Gly Leu Gln Ile Pro Gln Leu Pro Ala Pro Pro 
                85                  90                  95      


Lys Ile Tyr Phe Pro Ile Arg Asp Ser Trp Asn Ala Gly Ile 
            100                 105                 110 


<210>  1736
<211>  140
<212>  PRT
<213>  Homo Sapiens

<400>  1736

Met Arg Ser Glu Cys Val Leu Gly Ala Ala Ser Asp Ser Gly Gln Glu 
1               5                   10                  15      


Ala Pro Arg Asp Thr Trp Phe Leu Gln Gly Trp Lys Ala Ser Arg Arg 
            20                  25                  30          


Phe Leu Ile Lys Gly Ser Val Ala Gly Gly Ala Val Tyr Leu Val Tyr 
        35                  40                  45              


Asp Gln Glu Leu Leu Gly Pro Ser Asp Lys Ser Gln Ala Ala Leu Gln 
    50                  55                  60                  


Lys Ala Gly Glu Val Val Pro Pro Ala Met Tyr Gln Phe Ser Gln Tyr 
65                  70                  75                  80  


Val Cys Gln Gln Thr Gly Leu Gln Ile Pro Gln Leu Pro Ala Pro Pro 
                85                  90                  95      


Lys Ile Tyr Phe Pro Ile Arg Asp Ser Trp Asn Ala Gly Ile Met Thr 
            100                 105                 110         


Val Met Ser Ala Leu Ser Val Ala Pro Ser Lys Ala Arg Glu Tyr Ser 
        115                 120                 125             


Lys Glu Gly Trp Glu Tyr Val Lys Ala Arg Thr Lys 
    130                 135                 140 


<210>  1737
<211>  88
<212>  PRT
<213>  Homo Sapiens

<400>  1737

Met Val Ala Arg Val Trp Ser Leu Met Arg Phe Leu Ile Lys Gly Ser 
1               5                   10                  15      


Val Ala Gly Gly Ala Val Tyr Leu Val Tyr Asp Gln Glu Leu Leu Gly 
            20                  25                  30          


Pro Ser Asp Lys Ser Gln Ala Ala Leu Gln Lys Ala Gly Glu Val Val 
        35                  40                  45              


Pro Pro Ala Met Tyr Gln Phe Ser Gln Tyr Val Cys Gln Gln Thr Gly 
    50                  55                  60                  


Leu Gln Ile Pro Gln Leu Pro Ala Pro Pro Lys Ile Tyr Phe Pro Ile 
65                  70                  75                  80  


Arg Asp Ser Trp Asn Ala Gly Ile 
                85              


<210>  1738
<211>  118
<212>  PRT
<213>  Homo Sapiens

<400>  1738

Met Val Ala Arg Val Trp Ser Leu Met Arg Phe Leu Ile Lys Gly Ser 
1               5                   10                  15      


Val Ala Gly Gly Ala Val Tyr Leu Val Tyr Asp Gln Glu Leu Leu Gly 
            20                  25                  30          


Pro Ser Asp Lys Ser Gln Ala Ala Leu Gln Lys Ala Gly Glu Val Val 
        35                  40                  45              


Pro Pro Ala Met Tyr Gln Phe Ser Gln Tyr Val Cys Gln Gln Thr Gly 
    50                  55                  60                  


Leu Gln Ile Pro Gln Leu Pro Ala Pro Pro Lys Ile Tyr Phe Pro Ile 
65                  70                  75                  80  


Arg Asp Ser Trp Asn Ala Gly Ile Met Thr Val Met Ser Ala Leu Ser 
                85                  90                  95      


Val Ala Pro Ser Lys Ala Arg Glu Tyr Ser Lys Glu Gly Trp Glu Tyr 
            100                 105                 110         


Val Lys Ala Arg Thr Lys 
        115             


<210>  1739
<211>  100
<212>  PRT
<213>  Homo Sapiens

<400>  1739

Met Ala Ser Lys Ser Trp Leu Asn Phe Leu Thr Phe Leu Cys Gly Ser 
1               5                   10                  15      


Ala Ile Gly Phe Leu Leu Cys Ser Gln Leu Phe Ser Ile Leu Leu Gly 
            20                  25                  30          


Glu Lys Val Asp Thr Gln Pro Asn Val Leu His Asn Asp Pro His Ala 
        35                  40                  45              


Arg His Ser Asp Asp Asn Gly Gln Asn His Leu Glu Gly Gln Met Asn 
    50                  55                  60                  


Phe Asn Ala Asp Ser Ser Gln His Lys Asp Glu Asn Thr Asp Ile Ala 
65                  70                  75                  80  


Glu Asn Leu Tyr Gln Lys Val Arg Ile Leu Cys Trp Val Met Thr Gly 
                85                  90                  95      


Pro Gln Asn Leu 
            100 


<210>  1740
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  1740

Met Ala Ser Lys Ser Trp Leu Asn Phe Leu Thr Phe Leu Cys Gly Ser 
1               5                   10                  15      


Ala Ile Gly Phe Leu Leu Cys Ser Gln Leu Phe Ser Ile Leu Leu Gly 
            20                  25                  30          


Glu Lys Val Asp Thr Gln Pro Asn Val Leu His Asn Asp Pro His Ala 
        35                  40                  45              


Arg His Ser Asp Asp Asn Gly Gln Asn His Leu Glu Gly Gln Met Asn 
    50                  55                  60                  


Phe Asn Ala Asp Ser Ser Gln His Lys Asp Glu Asn Thr Asp Ile Ala 
65                  70                  75                  80  


Glu Asn Leu Tyr Gln Lys Val Arg Ile Leu Cys Trp Val Met Thr Gly 
                85                  90                  95      


Pro Gln Asn Leu Glu Lys Lys Ala Lys His Val Lys Ala Thr Trp Ala 
            100                 105                 110         


Gln Arg Cys Asn Lys Val Leu Phe Met Ser Ser Glu Glu Asn Lys Asp 
        115                 120                 125             


Phe Pro Ala 
    130     


<210>  1741
<211>  363
<212>  PRT
<213>  Homo Sapiens

<400>  1741

Met Ala Ser Lys Ser Trp Leu Asn Phe Leu Thr Phe Leu Cys Gly Ser 
1               5                   10                  15      


Ala Ile Gly Phe Leu Leu Cys Ser Gln Leu Phe Ser Ile Leu Leu Gly 
            20                  25                  30          


Glu Lys Val Asp Thr Gln Pro Asn Val Leu His Asn Asp Pro His Ala 
        35                  40                  45              


Arg His Ser Asp Asp Asn Gly Gln Asn His Leu Glu Gly Gln Met Asn 
    50                  55                  60                  


Phe Asn Ala Asp Ser Ser Gln His Lys Asp Glu Asn Thr Asp Ile Ala 
65                  70                  75                  80  


Glu Asn Leu Tyr Gln Lys Val Arg Ile Leu Cys Trp Val Met Thr Gly 
                85                  90                  95      


Pro Gln Asn Leu Glu Lys Lys Ala Lys His Val Lys Ala Thr Trp Ala 
            100                 105                 110         


Gln Arg Cys Asn Lys Val Leu Phe Met Ser Ser Glu Glu Asn Lys Asp 
        115                 120                 125             


Phe Pro Ala Val Gly Leu Lys Thr Lys Glu Gly Arg Asp Gln Leu Tyr 
    130                 135                 140                 


Trp Lys Thr Ile Lys Ala Phe Gln Tyr Val His Glu His Tyr Leu Glu 
145                 150                 155                 160 


Asp Ala Asp Trp Phe Leu Lys Ala Asp Asp Asp Thr Tyr Val Ile Leu 
                165                 170                 175     


Asp Asn Leu Arg Trp Leu Leu Ser Lys Tyr Asp Pro Glu Glu Pro Ile 
            180                 185                 190         


Tyr Phe Gly Arg Arg Phe Lys Pro Tyr Val Lys Gln Gly Tyr Met Ser 
        195                 200                 205             


Gly Gly Ala Gly Tyr Val Leu Ser Lys Glu Ala Leu Lys Arg Phe Val 
    210                 215                 220                 


Asp Ala Phe Lys Thr Asp Lys Cys Thr His Ser Ser Ser Ile Glu Asp 
225                 230                 235                 240 


Leu Ala Leu Gly Arg Cys Met Glu Ile Met Asn Val Glu Ala Gly Asp 
                245                 250                 255     


Ser Arg Asp Thr Ile Gly Lys Glu Thr Phe His Pro Phe Val Pro Glu 
            260                 265                 270         


His His Leu Ile Lys Gly Tyr Leu Pro Arg Thr Phe Trp Tyr Trp Asn 
        275                 280                 285             


Tyr Asn Tyr Tyr Pro Pro Val Glu Gly Pro Gly Cys Cys Ser Asp Leu 
    290                 295                 300                 


Ala Val Ser Phe His Tyr Val Asp Ser Thr Thr Met Tyr Glu Leu Glu 
305                 310                 315                 320 


Tyr Leu Val Tyr His Leu Arg Pro Tyr Gly Tyr Leu Tyr Arg Tyr Gln 
                325                 330                 335     


Pro Thr Leu Pro Glu Arg Ile Leu Lys Glu Ile Ser Gln Ala Asn Lys 
            340                 345                 350         


Asn Glu Asp Thr Lys Val Lys Leu Gly Asn Pro 
        355                 360             


<210>  1742
<211>  309
<212>  PRT
<213>  Homo Sapiens

<400>  1742

Met Ala Ser Lys Ser Trp Leu Asn Phe Leu Thr Phe Leu Cys Gly Ser 
1               5                   10                  15      


Ala Ile Gly Phe Leu Leu Cys Ser Gln Leu Phe Ser Ile Leu Leu Gly 
            20                  25                  30          


Glu Lys Val Asp Thr Gln Pro Asn Val Leu His Asn Asp Pro His Ala 
        35                  40                  45              


Arg His Ser Asp Asp Asn Gly Gln Asn His Leu Glu Gly Gln Met Asn 
    50                  55                  60                  


Phe Asn Ala Asp Ser Ser Gln His Lys Asp Glu Asn Thr Asp Ile Ala 
65                  70                  75                  80  


Glu Asn Leu Tyr Gln Lys Val Arg Ile Leu Cys Trp Val Met Thr Gly 
                85                  90                  95      


Pro Gln Asn Leu Glu Lys Lys Ala Lys His Val Lys Ala Thr Trp Ala 
            100                 105                 110         


Gln Arg Cys Asn Lys Val Leu Phe Met Ser Ser Glu Glu Asn Lys Asp 
        115                 120                 125             


Phe Pro Ala Val Gly Leu Lys Thr Lys Glu Gly Arg Asp Gln Leu Tyr 
    130                 135                 140                 


Trp Lys Thr Ile Lys Ala Phe Gln Tyr Val His Glu His Tyr Leu Glu 
145                 150                 155                 160 


Asp Ala Asp Trp Phe Leu Lys Ala Asp Asp Asp Thr Tyr Val Ile Leu 
                165                 170                 175     


Asp Asn Leu Arg Trp Leu Leu Ser Lys Tyr Asp Pro Glu Glu Pro Ile 
            180                 185                 190         


Tyr Phe Gly Arg Arg Phe Lys Pro Tyr Val Lys Gln Gly Tyr Met Ser 
        195                 200                 205             


Gly Gly Ala Gly Tyr Val Leu Ser Lys Glu Ala Leu Lys Arg Phe Val 
    210                 215                 220                 


Asp Ala Phe Lys Thr Asp Lys Cys Thr His Ser Ser Ser Ile Glu Asp 
225                 230                 235                 240 


Leu Ala Leu Gly Arg Cys Met Glu Ile Met Asn Val Glu Ala Gly Asp 
                245                 250                 255     


Ser Arg Asp Thr Ile Gly Lys Glu Thr Phe His Pro Phe Val Pro Glu 
            260                 265                 270         


His His Leu Ile Lys Gly Tyr Leu Pro Arg Thr Phe Trp Tyr Trp Asn 
        275                 280                 285             


Tyr Asn Tyr Tyr Pro Pro Val Glu Val Ser Leu Glu Ile Leu Leu Leu 
    290                 295                 300                 


Cys Gln Tyr Leu Asp 
305                 


<210>  1743
<211>  363
<212>  PRT
<213>  Homo Sapiens

<400>  1743

Met Ala Ser Lys Ser Trp Leu Asn Phe Leu Thr Phe Leu Cys Gly Ser 
1               5                   10                  15      


Ala Ile Gly Phe Leu Leu Cys Ser Gln Leu Phe Ser Ile Leu Leu Gly 
            20                  25                  30          


Glu Lys Val Asp Thr Gln Pro Asn Val Leu His Asn Asp Pro His Ala 
        35                  40                  45              


Arg His Ser Asp Asp Asn Gly Gln Asn His Leu Glu Gly Gln Met Asn 
    50                  55                  60                  


Phe Asn Ala Asp Ser Ser Gln His Lys Asp Glu Asn Thr Asp Ile Ala 
65                  70                  75                  80  


Glu Asn Leu Tyr Gln Lys Val Arg Ile Leu Cys Trp Val Met Thr Gly 
                85                  90                  95      


Pro Gln Asn Leu Glu Lys Lys Ala Lys His Val Lys Ala Thr Trp Ala 
            100                 105                 110         


Gln Arg Cys Asn Lys Val Leu Phe Met Ser Ser Glu Glu Asn Lys Asp 
        115                 120                 125             


Phe Pro Ala Val Gly Leu Lys Thr Lys Glu Gly Arg Asp Gln Leu Tyr 
    130                 135                 140                 


Trp Lys Thr Ile Lys Ala Phe Gln Tyr Val His Glu His Tyr Leu Glu 
145                 150                 155                 160 


Asp Ala Asp Trp Phe Leu Lys Ala Asp Asp Asp Thr Tyr Val Ile Leu 
                165                 170                 175     


Asp Asn Leu Arg Trp Leu Leu Ser Lys Tyr Asp Pro Glu Glu Pro Ile 
            180                 185                 190         


Tyr Phe Gly Arg Arg Phe Lys Pro Tyr Val Lys Gln Gly Tyr Met Ser 
        195                 200                 205             


Gly Gly Ala Gly Tyr Val Leu Ser Lys Glu Ala Leu Lys Arg Phe Val 
    210                 215                 220                 


Asp Ala Phe Lys Thr Asp Lys Cys Thr His Ser Ser Ser Ile Glu Asp 
225                 230                 235                 240 


Leu Ala Leu Gly Arg Cys Met Glu Ile Met Asn Val Glu Ala Gly Asp 
                245                 250                 255     


Ser Arg Asp Thr Ile Gly Lys Glu Thr Phe His Pro Phe Val Pro Glu 
            260                 265                 270         


His His Leu Ile Lys Gly Tyr Leu Pro Arg Thr Phe Trp Tyr Trp Asn 
        275                 280                 285             


Tyr Asn Tyr Tyr Pro Pro Val Glu Gly Pro Gly Cys Cys Ser Asp Leu 
    290                 295                 300                 


Ala Val Ser Phe His Tyr Val Asp Ser Thr Thr Met Tyr Glu Leu Glu 
305                 310                 315                 320 


Tyr Leu Val Tyr His Leu Arg Pro Tyr Gly Tyr Leu Tyr Arg Tyr Gln 
                325                 330                 335     


Pro Thr Leu Pro Glu Arg Ile Leu Lys Glu Ile Ser Gln Ala Asn Lys 
            340                 345                 350         


Asn Glu Asp Thr Lys Val Lys Leu Gly Asn Pro 
        355                 360             


<210>  1744
<211>  823
<212>  PRT
<213>  Homo Sapiens

<400>  1744

Met Trp Gly Ser Pro Ala Leu Ala Trp Ala Val Trp Leu Ala Cys Val 
1               5                   10                  15      


Gln Pro Thr Val Phe Pro Trp Ser Leu Ser Phe Arg Ser Asp Thr Asp 
            20                  25                  30          


Lys Pro Ser Ser Ala Ala Glu Val Leu Thr Glu Ala Ser Ser Cys Trp 
        35                  40                  45              


Thr Asp Thr Val Glu Cys Phe Ser Asp Tyr Met Thr Leu Trp Ile Pro 
    50                  55                  60                  


Arg Ser His Val Glu Gly Leu Arg Arg Trp Leu Ala Arg Thr Leu His 
65                  70                  75                  80  


Leu Pro Gly Thr Trp Arg Ser Pro Asp His Leu Asp Ser Ser Leu Ala 
                85                  90                  95      


Lys Cys Gly Tyr Phe Leu His Leu Ala Ser Asp Gly Asp Phe Leu Phe 
            100                 105                 110         


Arg Val Gln Tyr Ser Ala Cys Phe Val Gln Lys Glu Lys Ala Asn Tyr 
        115                 120                 125             


Arg Leu Glu Ile Arg Ile Phe Gln Lys Gly Val Met Gly Leu Glu Arg 
    130                 135                 140                 


Ser Asp Arg Tyr Ile Met Lys Cys Pro Met Leu Arg Ser Arg Leu Gly 
145                 150                 155                 160 


Gln Glu Ser Val His Cys Gly Pro Met Phe Ile Gln Val Ser Arg Pro 
                165                 170                 175     


Leu Pro Leu Trp Arg Asp Asn Arg Gln Thr Pro Trp Leu Leu Ser Leu 
            180                 185                 190         


Arg Gly Glu Leu Val Ala Ser Leu Glu Asp Ala Ser Leu Met Gly Leu 
        195                 200                 205             


Tyr Val Asp Met Asn Ala Thr Thr Val Thr Val Gln Ser Pro Arg Gln 
    210                 215                 220                 


Gly Leu Leu Gln Arg Trp Glu Val Leu Asn Thr Ser Ala Glu Leu Leu 
225                 230                 235                 240 


Pro Leu Trp Leu Val Ser Gly His His Ala Tyr Ser Leu Glu Ala Ala 
                245                 250                 255     


Cys Pro Pro Val Ser Phe Gln Pro Glu Ser Glu Val Leu Val His Ile 
            260                 265                 270         


Pro Lys Gln Arg Leu Gly Leu Val Lys Arg Gly Ser Tyr Ile Glu Glu 
        275                 280                 285             


Thr Leu Ser Leu Arg Phe Leu Arg Val His Gln Ser Asn Ile Phe Met 
    290                 295                 300                 


Val Thr Glu Asn Lys Asp Phe Val Val Val Ser Ile Pro Ala Ala Gly 
305                 310                 315                 320 


Val Leu Gln Val Gln Arg Cys Gln Glu Val Gly Gly Thr Pro Gly Thr 
                325                 330                 335     


Gln Ala Phe Tyr Arg Val Asp Leu Ser Leu Glu Phe Ala Glu Met Ala 
            340                 345                 350         


Ala Pro Val Leu Trp Thr Val Glu Ser Phe Phe Gln Cys Val Gly Ser 
        355                 360                 365             


Gly Thr Glu Ser Pro Ala Ser Thr Ala Ala Leu Arg Thr Thr Pro Ser 
    370                 375                 380                 


Pro Pro Ser Pro Gly Pro Glu Thr Pro Pro Ala Gly Val Pro Pro Ala 
385                 390                 395                 400 


Ala Ser Ser Gln Val Trp Ala Ala Gly Pro Ala Ala Gln Glu Trp Leu 
                405                 410                 415     


Ser Arg Asp Leu Leu His Arg Pro Ser Asp Ala Leu Ala Lys Lys Gly 
            420                 425                 430         


Leu Gly Pro Phe Leu Gln Thr Ala Lys Pro Ala Arg Arg Gly Gln Thr 
        435                 440                 445             


Ser Ala Ser Ile Leu Pro Arg Val Val Gln Ala Gln Arg Gly Pro Gln 
    450                 455                 460                 


Pro Pro Pro Gly Glu Ala Gly Ile Pro Gly His Pro Thr Pro Pro Ala 
465                 470                 475                 480 


Thr Leu Pro Ser Glu Pro Val Glu Gly Val Gln Ala Ser Pro Trp Arg 
                485                 490                 495     


Pro Arg Pro Val Leu Pro Thr His Pro Ala Leu Thr Leu Pro Val Ser 
            500                 505                 510         


Ser Asp Ala Ser Ser Pro Ser Pro Pro Ala Pro Arg Pro Glu Arg Pro 
        515                 520                 525             


Glu Ser Leu Leu Val Ser Gly Pro Ser Val Thr Leu Thr Glu Gly Leu 
    530                 535                 540                 


Gly Thr Val Arg Pro Glu Gln Asp Pro Ala Lys Ser Pro Gly Ser Pro 
545                 550                 555                 560 


Leu Leu Leu Arg Gly Leu Ser Ser Gly Asp Val Ala Ala Pro Glu Pro 
                565                 570                 575     


Ile Met Gly Glu Pro Gly Gln Ala Ser Glu Glu Phe Gln Pro Leu Ala 
            580                 585                 590         


Arg Pro Trp Arg Ala Thr Leu Ala Ala Glu Glu Leu Val Ser His Arg 
        595                 600                 605             


Ser Pro Gly Glu Pro Gln Glu Thr Cys Ser Gly Thr Glu Val Glu Arg 
    610                 615                 620                 


Pro Arg Gln Thr Gly Pro Gly Leu Pro Arg Glu Gly Ala Arg Gly His 
625                 630                 635                 640 


Met Asp Leu Ser Ser Ser Glu Pro Ser Gln Asp Ile Glu Gly Pro Gly 
                645                 650                 655     


Leu Ser Ile Leu Pro Ala Arg Asp Ala Thr Phe Ser Thr Pro Ser Val 
            660                 665                 670         


Arg Gln Pro Asp Pro Ser Ala Trp Leu Ser Ser Gly Pro Glu Leu Thr 
        675                 680                 685             


Gly Met Pro Arg Val Arg Leu Ala Ala Pro Leu Ala Val Leu Pro Met 
    690                 695                 700                 


Glu Pro Leu Pro Pro Glu Pro Val Arg Pro Ala Ala Leu Leu Thr Pro 
705                 710                 715                 720 


Glu Ala Ser Ser Val Gly Gly Pro Asp Gln Ala Arg Tyr Leu Glu Ser 
                725                 730                 735     


Ala Pro Gly Trp Pro Val Gly Gln Glu Glu Trp Gly Val Ala His Thr 
            740                 745                 750         


Ser Ser Pro Pro Ser Thr Gln Thr Leu Ser Leu Trp Ala Pro Thr Gly 
        755                 760                 765             


Val Leu Leu Pro Ser Leu Val Glu Leu Glu Tyr Pro Phe Gln Ala Gly 
    770                 775                 780                 


Arg Gly Ala Ser Leu Gln Gln Glu Leu Thr Glu Pro Thr Leu Ala Leu 
785                 790                 795                 800 


Ser Ala Glu Ser His Arg Pro Pro Glu Leu Gln Asp Ser Val Glu Gly 
                805                 810                 815     


Leu Ser Glu Arg Pro Ser Arg 
            820             


<210>  1745
<211>  658
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1745

Xaa Ile Met Lys Cys Pro Met Leu Arg Ser Arg Leu Gly Gln Glu Ser 
1               5                   10                  15      


Val His Cys Gly Pro Met Phe Ile Gln Val Ser Arg Pro Leu Pro Leu 
            20                  25                  30          


Trp Arg Asp Asn Arg Gln Thr Pro Trp Leu Leu Ser Leu Arg Gly Glu 
        35                  40                  45              


Leu Val Ala Ser Leu Glu Asp Ala Ser Leu Met Gly Leu Tyr Val Asp 
    50                  55                  60                  


Met Asn Ala Thr Thr Val Thr Val Gln Ser Pro Arg Gln Gly Leu Leu 
65                  70                  75                  80  


Gln Arg Trp Glu Val Ser Gly Gly Gln Gln Ala Leu Pro Gly Val Ser 
                85                  90                  95      


Phe Gln Pro Glu Ser Glu Val Leu Val His Ile Pro Lys Gln Arg Leu 
            100                 105                 110         


Gly Leu Val Lys Arg Gly Ser Tyr Ile Glu Glu Thr Leu Ser Leu Arg 
        115                 120                 125             


Phe Leu Arg Val His Gln Ser Asn Ile Phe Met Val Thr Glu Asn Lys 
    130                 135                 140                 


Asp Phe Val Val Val Ser Ile Pro Ala Ala Gly Val Leu Gln Val Gln 
145                 150                 155                 160 


Arg Cys Gln Glu Val Gly Gly Thr Pro Gly Thr Gln Ala Phe Tyr Arg 
                165                 170                 175     


Val Asp Leu Ser Leu Glu Phe Ala Glu Met Ala Ala Pro Val Leu Trp 
            180                 185                 190         


Thr Val Glu Ser Phe Phe Gln Cys Val Gly Ser Gly Thr Glu Ser Pro 
        195                 200                 205             


Ala Ser Thr Ala Ala Leu Arg Thr Thr Pro Ser Pro Pro Ser Pro Gly 
    210                 215                 220                 


Pro Glu Thr Pro Pro Ala Gly Val Pro Pro Ala Ala Ser Ser Gln Val 
225                 230                 235                 240 


Trp Ala Ala Gly Pro Ala Ala Gln Glu Trp Leu Ser Arg Asp Leu Leu 
                245                 250                 255     


His Arg Pro Ser Asp Ala Leu Ala Lys Lys Gly Leu Gly Pro Phe Leu 
            260                 265                 270         


Gln Thr Ala Lys Pro Ala Arg Arg Gly Gln Thr Ser Ala Ser Ile Leu 
        275                 280                 285             


Pro Arg Val Val Gln Ala Gln Arg Gly Pro Gln Pro Pro Pro Gly Glu 
    290                 295                 300                 


Ala Gly Ile Pro Gly His Pro Thr Pro Pro Ala Thr Leu Pro Ser Glu 
305                 310                 315                 320 


Pro Val Glu Gly Val Gln Ala Ser Pro Trp Arg Pro Arg Pro Val Leu 
                325                 330                 335     


Pro Thr His Pro Ala Leu Thr Leu Pro Val Ser Ser Asp Ala Ser Ser 
            340                 345                 350         


Pro Ser Pro Pro Ala Pro Arg Pro Glu Arg Pro Glu Ser Leu Leu Val 
        355                 360                 365             


Ser Gly Pro Ser Val Thr Leu Thr Glu Gly Leu Gly Thr Val Arg Pro 
    370                 375                 380                 


Glu Gln Asp Pro Ala Lys Ser Pro Gly Ser Pro Leu Leu Leu Arg Gly 
385                 390                 395                 400 


Leu Ser Ser Gly Asp Val Ala Ala Pro Glu Pro Ile Met Gly Glu Pro 
                405                 410                 415     


Gly Gln Ala Ser Glu Glu Phe Gln Pro Leu Ala Arg Pro Trp Arg Ala 
            420                 425                 430         


Thr Leu Ala Ala Glu Glu Leu Val Ser His Arg Ser Pro Gly Glu Pro 
        435                 440                 445             


Gln Glu Thr Cys Ser Gly Thr Glu Val Glu Arg Pro Arg Gln Thr Gly 
    450                 455                 460                 


Pro Gly Leu Pro Arg Glu Gly Ala Arg Gly His Met Asp Leu Ser Ser 
465                 470                 475                 480 


Ser Glu Pro Ser Gln Asp Ile Glu Gly Pro Gly Leu Ser Ile Leu Pro 
                485                 490                 495     


Ala Arg Asp Ala Thr Phe Ser Thr Pro Ser Val Arg Gln Pro Asp Pro 
            500                 505                 510         


Ser Ala Trp Leu Ser Ser Gly Pro Glu Leu Thr Gly Met Pro Arg Val 
        515                 520                 525             


Arg Leu Ala Ala Pro Leu Ala Val Leu Pro Met Glu Pro Leu Pro Pro 
    530                 535                 540                 


Glu Pro Val Arg Pro Ala Ala Leu Leu Thr Pro Glu Ala Ser Ser Val 
545                 550                 555                 560 


Gly Gly Pro Asp Gln Ala Arg Tyr Leu Glu Ser Ala Pro Gly Trp Pro 
                565                 570                 575     


Val Gly Gln Glu Glu Trp Gly Val Ala His Thr Ser Ser Pro Pro Ser 
            580                 585                 590         


Thr Gln Thr Leu Ser Leu Trp Ala Pro Thr Gly Val Leu Leu Pro Ser 
        595                 600                 605             


Leu Val Glu Leu Glu Tyr Pro Phe Gln Ala Gly Arg Gly Ala Ser Leu 
    610                 615                 620                 


Gln Gln Glu Leu Thr Glu Pro Thr Leu Ala Leu Ser Ala Glu Ser His 
625                 630                 635                 640 


Arg Pro Pro Glu Leu Gln Asp Ser Val Glu Gly Leu Ser Glu Arg Pro 
                645                 650                 655     


Ser Arg 
        


<210>  1746
<211>  69
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1746

Xaa Pro Ser Thr Gln Thr Leu Ser Leu Trp Ala Pro Thr Gly Val Leu 
1               5                   10                  15      


Leu Pro Ser Leu Val Glu Leu Glu Tyr Pro Phe Gln Ala Gly Arg Gly 
            20                  25                  30          


Ala Ser Leu Gln Gln Glu Leu Thr Glu Pro Thr Leu Ala Leu Ser Ala 
        35                  40                  45              


Glu Ser His Arg Pro Pro Glu Leu Gln Asp Ser Val Glu Gly Leu Ser 
    50                  55                  60                  


Glu Arg Pro Ser Arg 
65                  


<210>  1747
<211>  775
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1747

Xaa Ser Leu Ser Phe Arg Ser Asp Thr Asp Lys Pro Ser Ser Ala Ala 
1               5                   10                  15      


Glu Val Leu Thr Glu Ala Ser Ser Cys Trp Thr Asp Thr Val Glu Cys 
            20                  25                  30          


Phe Ser Asp Tyr Met Thr Leu Trp Ile Pro Arg Ser His Val Glu Gly 
        35                  40                  45              


Leu Arg Arg Trp Leu Ala Arg Thr Leu His Leu Pro Gly Thr Trp Arg 
    50                  55                  60                  


Ser Pro Asp His Leu Asp Ser Ser Leu Ala Lys Cys Gly Tyr Phe Leu 
65                  70                  75                  80  


His Leu Ala Ser Asp Gly Asp Phe Leu Phe Arg Val Gln Tyr Ser Ala 
                85                  90                  95      


Cys Phe Val Gln Lys Glu Lys Ala Asn Tyr Arg Leu Glu Ile Arg Ile 
            100                 105                 110         


Phe Gln Lys Gly Val Met Gly Leu Glu Arg Ser Asp Arg Tyr Ile Met 
        115                 120                 125             


Lys Cys Pro Met Leu Arg Ser Arg Leu Gly Gln Glu Ser Val His Cys 
    130                 135                 140                 


Gly Pro Met Phe Ile Gln Val Ser Arg Pro Leu Pro Leu Trp Arg Asp 
145                 150                 155                 160 


Asn Arg Gln Thr Pro Trp Leu Leu Ser Leu Arg Gly Glu Leu Val Ala 
                165                 170                 175     


Ser Leu Glu Asp Ala Ser Leu Met Gly Leu Tyr Val Asp Met Asn Ala 
            180                 185                 190         


Thr Thr Val Thr Val Gln Ser Pro Arg Gln Gly Leu Leu Gln Arg Trp 
        195                 200                 205             


Glu Val Leu Asn Thr Ser Ala Glu Leu Leu Pro Leu Trp Leu Val Ser 
    210                 215                 220                 


Gly His His Ala Tyr Ser Leu Glu Ala Ala Cys Pro Pro Val Ser Phe 
225                 230                 235                 240 


Gln Pro Glu Ser Glu Val Leu Val His Ile Pro Lys Gln Arg Leu Gly 
                245                 250                 255     


Leu Val Lys Arg Gly Ser Tyr Ile Glu Glu Thr Leu Ser Leu Arg Phe 
            260                 265                 270         


Leu Arg Val His Gln Ser Asn Ile Phe Met Val Thr Glu Asn Lys Asp 
        275                 280                 285             


Phe Val Val Val Ser Ile Pro Ala Ala Gly Val Leu Gln Val Gln Arg 
    290                 295                 300                 


Cys Gln Glu Val Gly Gly Thr Pro Gly Thr Gln Ala Phe Tyr Arg Val 
305                 310                 315                 320 


Asp Leu Ser Leu Glu Phe Ala Glu Met Ala Ala Pro Val Leu Trp Thr 
                325                 330                 335     


Val Glu Ser Phe Phe Gln Cys Val Gly Ser Gly Thr Glu Ser Pro Ala 
            340                 345                 350         


Ser Thr Ala Ala Leu Arg Thr Thr Pro Ser Pro Pro Ser Pro Gly Pro 
        355                 360                 365             


Glu Thr Pro Pro Ala Gly Val Pro Pro Ala Ala Ser Ser Gln Lys Gly 
    370                 375                 380                 


Leu Gly Pro Phe Leu Gln Thr Ala Lys Pro Ala Arg Arg Gly Gln Thr 
385                 390                 395                 400 


Ser Ala Ser Ile Leu Pro Arg Val Val Gln Ala Gln Arg Gly Pro Gln 
                405                 410                 415     


Pro Pro Pro Gly Glu Ala Gly Ile Pro Gly His Pro Thr Pro Pro Ala 
            420                 425                 430         


Thr Leu Pro Ser Glu Pro Val Glu Gly Val Gln Ala Ser Pro Trp Arg 
        435                 440                 445             


Pro Arg Pro Val Leu Pro Thr His Pro Ala Leu Thr Leu Pro Val Ser 
    450                 455                 460                 


Ser Asp Ala Ser Ser Pro Ser Pro Pro Ala Pro Arg Pro Glu Arg Pro 
465                 470                 475                 480 


Glu Ser Leu Leu Val Ser Gly Pro Ser Val Thr Leu Thr Glu Gly Leu 
                485                 490                 495     


Gly Thr Val Arg Pro Glu Gln Asp Pro Ala Lys Ser Pro Gly Ser Pro 
            500                 505                 510         


Leu Leu Leu Arg Gly Leu Ser Ser Gly Asp Val Ala Ala Pro Glu Pro 
        515                 520                 525             


Ile Met Gly Glu Pro Gly Gln Ala Ser Glu Glu Phe Gln Pro Leu Ala 
    530                 535                 540                 


Arg Pro Trp Arg Ala Thr Leu Ala Ala Glu Glu Leu Val Ser His Arg 
545                 550                 555                 560 


Ser Pro Gly Glu Pro Gln Glu Thr Cys Ser Gly Thr Glu Val Glu Arg 
                565                 570                 575     


Pro Arg Gln Thr Gly Pro Gly Leu Pro Arg Glu Gly Ala Arg Gly His 
            580                 585                 590         


Met Asp Leu Ser Ser Ser Glu Pro Ser Gln Asp Ile Glu Gly Pro Gly 
        595                 600                 605             


Leu Ser Ile Leu Pro Ala Arg Asp Ala Thr Phe Ser Thr Pro Ser Val 
    610                 615                 620                 


Arg Gln Pro Asp Pro Ser Ala Trp Leu Ser Ser Gly Pro Glu Leu Thr 
625                 630                 635                 640 


Gly Met Pro Arg Val Arg Leu Ala Ala Pro Leu Ala Val Leu Pro Met 
                645                 650                 655     


Glu Pro Leu Pro Pro Glu Pro Val Arg Pro Ala Ala Leu Leu Thr Pro 
            660                 665                 670         


Glu Ala Ser Ser Val Gly Gly Pro Asp Gln Ala Arg Tyr Leu Glu Ser 
        675                 680                 685             


Ala Pro Gly Trp Pro Val Gly Gln Glu Glu Trp Gly Val Ala His Thr 
    690                 695                 700                 


Ser Ser Pro Pro Ser Thr Gln Thr Leu Ser Leu Trp Ala Pro Thr Gly 
705                 710                 715                 720 


Val Leu Leu Pro Ser Leu Val Glu Leu Glu Tyr Pro Phe Gln Ala Gly 
                725                 730                 735     


Arg Gly Ala Ser Leu Gln Gln Glu Leu Thr Glu Pro Thr Leu Ala Leu 
            740                 745                 750         


Ser Ala Glu Ser His Arg Pro Pro Glu Leu Gln Asp Ser Val Glu Gly 
        755                 760                 765             


Leu Ser Glu Arg Pro Ser Arg 
    770                 775 


<210>  1748
<211>  15
<212>  PRT
<213>  Homo Sapiens

<400>  1748

Met Ala Leu Arg His Leu Ala Leu Leu Ala Gly Leu Leu Val Gly 
1               5                   10                  15  


<210>  1749
<211>  57
<212>  PRT
<213>  Homo Sapiens

<400>  1749

Met Ala Leu Arg His Leu Ala Leu Leu Ala Gly Leu Leu Val Gly Val 
1               5                   10                  15      


Ala Ser Lys Ser Met Glu Asn Thr Ala Gln Leu Pro Glu Cys Cys Val 
            20                  25                  30          


Asp Val Val Gly Val Asn Ala Ser Cys Pro Gly Ala Ser Leu Cys Gly 
        35                  40                  45              


Pro Gly Cys Tyr Arg Arg Trp Asn Ala 
    50                  55          


<210>  1750
<211>  86
<212>  PRT
<213>  Homo Sapiens

<400>  1750

Met Ala Leu Arg His Leu Ala Leu Leu Ala Gly Leu Leu Val Gly Val 
1               5                   10                  15      


Ala Ser Lys Ser Met Glu Asn Thr Ala Gln Leu Pro Glu Cys Cys Val 
            20                  25                  30          


Asp Val Val Gly Val Asn Ala Ser Cys Pro Gly Ala Ser Leu Cys Gly 
        35                  40                  45              


Pro Gly Cys Tyr Arg Arg Trp Asn Ala Asp Gly Ser Ala Ser Cys Val 
    50                  55                  60                  


Arg Cys Gly Asn Gly Thr Leu Pro Ala Tyr Asn Gly Ser Glu Cys Arg 
65                  70                  75                  80  


Ser Phe Ala Gly Pro Gly 
                85      


<210>  1751
<211>  103
<212>  PRT
<213>  Homo Sapiens

<400>  1751

Met Ala Leu Arg His Leu Ala Leu Leu Ala Gly Leu Leu Val Gly Val 
1               5                   10                  15      


Ala Ser Lys Ser Met Glu Asn Thr Ala Gln Leu Pro Glu Cys Cys Val 
            20                  25                  30          


Asp Val Val Gly Val Asn Ala Ser Cys Pro Gly Ala Ser Leu Cys Gly 
        35                  40                  45              


Pro Gly Cys Tyr Arg Arg Trp Asn Ala Asp Gly Ser Ala Ser Cys Val 
    50                  55                  60                  


Arg Cys Gly Asn Gly Thr Leu Pro Ala Tyr Asn Gly Ser Glu Cys Arg 
65                  70                  75                  80  


Ser Phe Ala Gly Pro Gly Ala Pro Phe Pro Met Asn Arg Ser Ser Gly 
                85                  90                  95      


Thr Pro Gly Arg Pro His Pro 
            100             


<210>  1752
<211>  224
<212>  PRT
<213>  Homo Sapiens

<400>  1752

Met Ala Leu Arg His Leu Ala Leu Leu Ala Gly Leu Leu Val Gly Val 
1               5                   10                  15      


Ala Ser Lys Ser Met Glu Asn Thr Ala Gln Leu Pro Glu Cys Cys Val 
            20                  25                  30          


Asp Val Val Gly Val Asn Ala Ser Cys Pro Gly Ala Ser Leu Cys Gly 
        35                  40                  45              


Pro Gly Cys Tyr Arg Arg Trp Asn Ala Asp Gly Ser Ala Ser Cys Val 
    50                  55                  60                  


Arg Cys Gly Asn Gly Thr Leu Pro Ala Tyr Asn Gly Ser Glu Cys Arg 
65                  70                  75                  80  


Ser Phe Ala Gly Pro Gly Ala Pro Phe Pro Met Asn Arg Ser Ser Gly 
                85                  90                  95      


Thr Pro Gly Arg Pro His Pro Gly Ala Pro Arg Val Ala Ala Ser Leu 
            100                 105                 110         


Phe Leu Gly Thr Phe Phe Ile Ser Ser Gly Leu Ile Leu Ser Val Ala 
        115                 120                 125             


Gly Phe Phe Tyr Leu Lys Arg Ser Ser Lys Leu Pro Arg Ala Cys Tyr 
    130                 135                 140                 


Arg Arg Asn Lys Ala Pro Ala Leu Gln Pro Gly Glu Ala Ala Ala Met 
145                 150                 155                 160 


Ile Pro Pro Pro Gln Ser Ser Ala Pro Pro Glu Asp Arg Arg Ser Arg 
                165                 170                 175     


Pro Pro Pro Gly Pro Pro Glu Gln Pro Ser Leu Gln Trp Cys Trp Val 
            180                 185                 190         


Arg Arg Thr Gln Glu Ser Ala Arg Thr Glu Ala Ala Leu Arg Gln Ala 
        195                 200                 205             


Gly Ala Ala Pro Gly Gln Gly His Gly Ser Arg Cys Leu Pro Gly Gly 
    210                 215                 220                 


<210>  1753
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  1753

Met Ala Leu Arg His Leu Ala Leu Leu Ala Gly Leu Leu Val Gly Val 
1               5                   10                  15      


Ala Ser Lys Ser Met Glu Asn Thr Ala Gln Leu Pro Glu Cys Cys Val 
            20                  25                  30          


Asp Val Val Gly Val Asn Ala Ser Cys Pro Gly Ala Ser Leu Cys Gly 
        35                  40                  45              


Pro Gly Cys Tyr Arg Arg Trp Asn Ala Asp Gly Ser Ala Ser Cys Val 
    50                  55                  60                  


Arg Cys Gly Asn Gly Thr Leu Pro Ala Tyr Asn Gly Ser Glu Cys Arg 
65                  70                  75                  80  


Ser Phe Ala Gly Pro Gly Ala Pro Phe Pro Met Asn Arg Ser Ser Gly 
                85                  90                  95      


Thr Pro Gly Arg Pro His Pro Gly Ala Pro Arg Val Ala Ala Ser Leu 
            100                 105                 110         


Phe Leu Gly Thr Phe Phe Ile Ser Ser Gly Leu Ile Leu Ser Val Ala 
        115                 120                 125             


Gly Phe Phe Tyr Leu Lys Arg Ser Ser Lys Leu Pro Arg Ala Cys Tyr 
    130                 135                 140                 


Arg Arg Asn Lys Ala Pro Ala Leu Gln Pro Gly Glu Ala Ala Ala Met 
145                 150                 155                 160 


Ile Pro Pro Pro Gln Ser Ser Asp Val Gly Ser Ala Gly Lys Glu Asp 
                165                 170                 175     


Pro Pro Arg Gln Gly Arg Pro Pro Ile Pro Ala Pro Pro 
            180                 185                 


<210>  1754
<211>  344
<212>  PRT
<213>  Homo Sapiens

<400>  1754

Met Ala Leu Arg His Leu Ala Leu Leu Ala Gly Leu Leu Val Gly Val 
1               5                   10                  15      


Ala Ser Lys Ser Met Glu Asn Thr Ala Gln Leu Pro Glu Cys Cys Val 
            20                  25                  30          


Asp Val Val Gly Val Asn Ala Ser Cys Pro Gly Ala Ser Leu Cys Gly 
        35                  40                  45              


Pro Gly Cys Tyr Arg Arg Trp Asn Ala Asp Gly Ser Ala Ser Cys Val 
    50                  55                  60                  


Arg Cys Gly Asn Gly Thr Leu Pro Ala Tyr Asn Gly Ser Glu Cys Arg 
65                  70                  75                  80  


Ser Phe Ala Gly Pro Gly Ala Pro Phe Pro Met Asn Arg Ser Ser Gly 
                85                  90                  95      


Thr Pro Gly Arg Pro His Pro Gly Ala Pro Arg Val Ala Ala Ser Leu 
            100                 105                 110         


Phe Leu Gly Thr Phe Phe Ile Ser Ser Gly Leu Ile Leu Ser Val Ala 
        115                 120                 125             


Gly Phe Phe Tyr Leu Lys Arg Ser Ser Lys Leu Pro Arg Ala Cys Tyr 
    130                 135                 140                 


Arg Arg Asn Lys Ala Pro Ala Leu Gln Pro Gly Glu Ala Ala Ala Met 
145                 150                 155                 160 


Ile Pro Pro Pro Gln Ser Ser Gly Asn Ser Ser Cys Arg Ile Pro Leu 
                165                 170                 175     


Trp Gly Phe Pro Ser Leu Gly Gln Ser Gln Gly Ala Leu Trp Val Cys 
            180                 185                 190         


Pro Gln Thr Gly Leu Pro Gly Ser Gly Ser Arg Pro Pro Leu Pro Gly 
        195                 200                 205             


Ser Pro Gly Asp Pro Pro Thr Arg Gln Gly Gln Gly Arg Ile Trp Leu 
    210                 215                 220                 


Val Pro Pro Ala Leu Asp Leu Ser Trp Ile Trp Pro Ala Pro Pro Ala 
225                 230                 235                 240 


Arg Pro Pro Leu Ile Pro Val Thr Ser Met Leu Phe Pro Val Pro Glu 
                245                 250                 255     


Thr Trp Gly Leu Gln Glu Arg Arg Thr His His Asp Arg Ala Asp Pro 
            260                 265                 270         


Gln Tyr Leu Leu Leu Leu Glu Val Gln Leu His Pro Arg Thr Asp Ala 
        275                 280                 285             


Ala Gly Leu Arg Gln Ala Leu Leu Ser Ser His Arg Phe Ser Gly Ala 
    290                 295                 300                 


Gly Ser Gly Gly Pro Lys Ser Gln Pro Val Arg Lys Pro Arg Tyr Val 
305                 310                 315                 320 


Arg Arg Glu Arg Pro Leu Asp Arg Ala Thr Asp Pro Ala Ala Phe Pro 
                325                 330                 335     


Gly Glu Ala Arg Ile Ser Asn Val 
            340                 


<210>  1755
<211>  198
<212>  PRT
<213>  Homo Sapiens

<400>  1755

Met Ala Leu Arg His Leu Ala Leu Leu Ala Gly Leu Leu Val Gly Val 
1               5                   10                  15      


Ala Ser Lys Ser Met Glu Asn Thr Ala Gln Leu Pro Glu Cys Cys Val 
            20                  25                  30          


Asp Val Val Gly Val Asn Ala Ser Cys Pro Gly Ala Ser Leu Cys Gly 
        35                  40                  45              


Pro Gly Cys Tyr Arg Arg Trp Asn Ala Asp Gly Ser Ala Ser Cys Val 
    50                  55                  60                  


Arg Cys Gly Asn Gly Thr Leu Pro Ala Tyr Asn Gly Ser Glu Cys Arg 
65                  70                  75                  80  


Ser Phe Ala Gly Pro Gly Ala Pro Phe Pro Met Asn Arg Ser Ser Gly 
                85                  90                  95      


Thr Pro Gly Arg Pro His Pro Gly Ala Pro Arg Val Ala Ala Ser Leu 
            100                 105                 110         


Phe Leu Gly Thr Phe Phe Ile Ser Ser Gly Leu Ile Leu Ser Val Ala 
        115                 120                 125             


Gly Phe Phe Tyr Leu Lys Arg Ser Ser Lys Leu Pro Arg Ala Cys Tyr 
    130                 135                 140                 


Arg Arg Asn Lys Ala Pro Ala Leu Gln Pro Gly Glu Ala Ala Ala Met 
145                 150                 155                 160 


Ile Pro Pro Pro Gln Ser Ser Val Arg Lys Pro Arg Tyr Val Arg Arg 
                165                 170                 175     


Glu Arg Pro Leu Asp Arg Ala Thr Asp Pro Ala Ala Phe Pro Gly Glu 
            180                 185                 190         


Ala Arg Ile Ser Asn Val 
        195             


<210>  1756
<211>  198
<212>  PRT
<213>  Homo Sapiens

<400>  1756

Met Ala Leu Arg His Leu Ala Leu Leu Ala Gly Leu Leu Val Gly Val 
1               5                   10                  15      


Ala Ser Lys Ser Met Glu Asn Thr Ala Gln Leu Pro Glu Cys Cys Val 
            20                  25                  30          


Asp Val Val Gly Val Asn Ala Ser Cys Pro Gly Ala Ser Leu Cys Gly 
        35                  40                  45              


Pro Gly Cys Tyr Arg Arg Trp Asn Ala Asp Gly Ser Ala Ser Cys Val 
    50                  55                  60                  


Arg Cys Gly Asn Gly Thr Leu Pro Ala Tyr Asn Gly Ser Glu Cys Arg 
65                  70                  75                  80  


Ser Phe Ala Gly Pro Gly Ala Pro Phe Pro Met Asn Arg Ser Ser Gly 
                85                  90                  95      


Thr Pro Gly Arg Pro His Pro Gly Ala Pro Arg Val Ala Ala Ser Leu 
            100                 105                 110         


Phe Leu Gly Thr Phe Phe Ile Ser Ser Gly Leu Ile Leu Ser Val Ala 
        115                 120                 125             


Gly Phe Phe Tyr Leu Lys Arg Ser Ser Lys Leu Pro Arg Ala Cys Tyr 
    130                 135                 140                 


Arg Arg Asn Lys Ala Pro Ala Leu Gln Pro Gly Glu Ala Ala Ala Met 
145                 150                 155                 160 


Ile Pro Pro Pro Gln Ser Ser Val Arg Lys Pro Arg Tyr Val Arg Arg 
                165                 170                 175     


Glu Arg Pro Leu Asp Arg Ala Thr Asp Pro Ala Ala Phe Pro Gly Glu 
            180                 185                 190         


Ala Arg Ile Ser Asn Val 
        195             


<210>  1757
<211>  98
<212>  PRT
<213>  Homo Sapiens

<400>  1757

Met Ala Leu Arg His Leu Ala Leu Leu Ala Gly Leu Leu Val Gly Val 
1               5                   10                  15      


Ala Ser Lys Ser Met Glu Asn Thr Asp Thr Asp Val Pro Ala Pro Glu 
            20                  25                  30          


Val Leu Thr Arg Ser Thr Ala Gly Val Arg Gly Ala Cys Ala Ser Gln 
        35                  40                  45              


Arg Gly Ala Leu Arg Cys Leu Leu Gly Glu Arg Leu Leu Arg Asn Gly 
    50                  55                  60                  


Trp Val Arg Arg Gly Pro His Gly Glu Ala Ser Trp Pro Ala Met Gly 
65                  70                  75                  80  


Ala Pro Leu Pro Ala Val Thr Ala Gln Arg Ala Ala His Arg Tyr Arg 
                85                  90                  95      


Gly Val 
        


<210>  1758
<211>  64
<212>  PRT
<213>  Homo Sapiens

<400>  1758

Met Ala Leu Arg His Leu Ala Leu Leu Ala Gly Leu Leu Val Gly Val 
1               5                   10                  15      


Ala Ser Lys Ser Met Glu Asn Thr Asp Thr Asp Val Pro Ala Pro Glu 
            20                  25                  30          


Val Leu Thr Arg Ser Thr Ala Gly Val Arg Gly Ala Cys Ala Ser Gln 
        35                  40                  45              


Arg Gly Ala Leu Arg Cys Leu Leu Gly Pro Ala Ala Arg Val Leu Cys 
    50                  55                  60                  


<210>  1759
<211>  111
<212>  PRT
<213>  Homo Sapiens

<400>  1759

Met Ala Leu Arg His Leu Ala Leu Leu Ala Gly Leu Leu Val Gly Val 
1               5                   10                  15      


Ala Ser Lys Ser Met Glu Asn Thr Asp Thr Asp Val Pro Ala Pro Glu 
            20                  25                  30          


Val Leu Thr Arg Ser Thr Ala Gly Val Arg Gly Ala Cys Ala Ser Gln 
        35                  40                  45              


Arg Gly Ala Leu Arg Cys Leu Leu Gly Pro Ala Ala Arg Val Leu Cys 
    50                  55                  60                  


Gly Cys Gly Gly Arg Gln Arg Gln Leu Pro Arg Arg Lys Ser Val Trp 
65                  70                  75                  80  


Ser Arg Leu Leu Gln Ala Leu Glu Arg Gly Arg Glu Arg Gln Leu Arg 
                85                  90                  95      


Pro Leu Trp Glu Arg Asn Pro Pro Ser Leu Gln Arg Leu Arg Val 
            100                 105                 110     


<210>  1760
<211>  380
<212>  PRT
<213>  Homo Sapiens

<400>  1760

Met Ala Leu Arg His Leu Ala Leu Leu Ala Gly Leu Leu Val Gly Val 
1               5                   10                  15      


Ala Ser Lys Ser Met Glu Asn Thr Val Thr Arg Asn Ser Thr Ala Val 
            20                  25                  30          


Ile Asn Thr Gln Ala Glu Gly Thr Leu Ser Pro Pro Gly Leu Ser Ser 
        35                  40                  45              


Leu Pro Val Val Arg Glu Trp Ala Leu Thr His Thr Ala Gln Leu Pro 
    50                  55                  60                  


Glu Cys Cys Val Asp Val Val Gly Val Asn Ala Ser Cys Pro Gly Ala 
65                  70                  75                  80  


Ser Leu Cys Gly Pro Gly Cys Tyr Arg Arg Trp Asn Ala Asp Gly Ser 
                85                  90                  95      


Ala Ser Cys Val Arg Cys Gly Asn Gly Thr Leu Pro Ala Tyr Asn Gly 
            100                 105                 110         


Ser Glu Cys Arg Ser Phe Ala Gly Pro Gly Ala Pro Phe Pro Met Asn 
        115                 120                 125             


Arg Ser Ser Gly Thr Pro Gly Arg Pro His Pro Gly Ala Pro Arg Val 
    130                 135                 140                 


Ala Ala Ser Leu Phe Leu Gly Thr Phe Phe Ile Ser Ser Gly Leu Ile 
145                 150                 155                 160 


Leu Ser Val Ala Gly Phe Phe Tyr Leu Lys Arg Ser Ser Lys Leu Pro 
                165                 170                 175     


Arg Ala Cys Tyr Arg Arg Asn Lys Ala Pro Ala Leu Gln Pro Gly Glu 
            180                 185                 190         


Ala Ala Ala Met Ile Pro Pro Pro Gln Ser Ser Gly Asn Ser Ser Cys 
        195                 200                 205             


Arg Ile Pro Leu Trp Gly Phe Pro Ser Leu Gly Gln Ser Gln Gly Ala 
    210                 215                 220                 


Leu Trp Val Cys Pro Gln Thr Gly Leu Pro Gly Ser Gly Ser Arg Pro 
225                 230                 235                 240 


Pro Leu Pro Gly Ser Pro Gly Asp Pro Pro Thr Arg Gln Gly Gln Gly 
                245                 250                 255     


Arg Ile Trp Leu Val Pro Pro Ala Leu Asp Leu Ser Trp Ile Trp Pro 
            260                 265                 270         


Ala Pro Pro Ala Arg Pro Pro Leu Ile Pro Val Thr Ser Met Leu Phe 
        275                 280                 285             


Pro Val Pro Glu Thr Trp Gly Leu Gln Glu Arg Arg Thr His His Asp 
    290                 295                 300                 


Arg Ala Asp Pro Gln Tyr Leu Leu Leu Leu Glu Val Gln Leu His Pro 
305                 310                 315                 320 


Arg Thr Asp Ala Ala Gly Leu Arg Gln Ala Leu Leu Ser Ser His Arg 
                325                 330                 335     


Phe Ser Gly Ala Gly Ser Gly Gly Pro Lys Ser Gln Pro Val Arg Lys 
            340                 345                 350         


Pro Arg Tyr Val Arg Arg Glu Arg Pro Leu Asp Arg Ala Thr Asp Pro 
        355                 360                 365             


Ala Ala Phe Pro Gly Glu Ala Arg Ile Ser Asn Val 
    370                 375                 380 


<210>  1761
<211>  289
<212>  PRT
<213>  Homo Sapiens

<400>  1761

Met Ala Arg Lys Ile Met Gln Asp Lys Glu Lys Ile Arg Glu Lys Tyr 
1               5                   10                  15      


Gly Pro Glu Trp Ala Arg Leu Pro Pro Ala Gln Gln Asp Glu Ile Ile 
            20                  25                  30          


Asp Arg Cys Leu Val Gly Pro Arg Ala Pro Ala Pro Arg Asp Pro Gly 
        35                  40                  45              


Asp Ser Glu Glu Leu Thr Arg Phe Pro Gly Leu Arg Gly Pro Thr Gly 
    50                  55                  60                  


Gln Lys Val Val Arg Phe Gly Asp Glu Asp Leu Thr Trp Gln Asp Glu 
65                  70                  75                  80  


His Ser Ala Pro Phe Ser Trp Glu Thr Lys Ser Gln Met Glu Phe Ser 
                85                  90                  95      


Ile Ser Ala Leu Ser Ile Gln Glu Pro Ser Asn Gly Thr Ala Ala Ser 
            100                 105                 110         


Glu Pro Arg Pro Leu Ser Lys Ala Ser Gln Gly Ser Gln Ala Leu Lys 
        115                 120                 125             


Ser Ser Gln Gly Ser Arg Ser Ser Ser Leu Asp Ala Leu Gly Pro Thr 
    130                 135                 140                 


Arg Lys Glu Glu Glu Ala Ser Phe Trp Lys Ile Asn Ala Glu Arg Ser 
145                 150                 155                 160 


Arg Gly Glu Gly Pro Glu Ala Glu Phe Gln Ser Leu Thr Pro Ser Gln 
                165                 170                 175     


Ile Lys Ser Met Glu Lys Gly Glu Lys Val Leu Pro Pro Cys Tyr Arg 
            180                 185                 190         


Gln Glu Pro Ala Pro Lys Asp Arg Glu Ala Lys Val Glu Arg Pro Ser 
        195                 200                 205             


Thr Leu Arg Gln Glu Gln Arg Pro Leu Pro Asn Val Ser Thr Glu Arg 
    210                 215                 220                 


Glu Arg Pro Gln Pro Val Gln Ala Phe Ser Ser Ala Leu His Glu Ala 
225                 230                 235                 240 


Ala Pro Ser Gln Leu Glu Gly Lys Leu Pro Ser Pro Asp Val Arg Gln 
                245                 250                 255     


Asp Asp Gly Glu Asp Thr Leu Phe Ser Glu Pro Lys Phe Ala Gln Val 
            260                 265                 270         


Ser Ser Ser Asn Val Val Leu Lys Thr Gly Phe Asp Phe Leu Asp Asn 
        275                 280                 285             


Trp 
    


<210>  1762
<211>  327
<212>  PRT
<213>  Homo Sapiens

<400>  1762

Met Ala Ser Met Ala Ala Ala Ile Ala Ala Ser Arg Ser Ala Val Met 
1               5                   10                  15      


Ser Gly Asn Arg Pro Leu Asp Asp Arg Glu Arg Lys Arg Phe Thr Tyr 
            20                  25                  30          


Phe Ser Ser Leu Ser Pro Met Ala Arg Lys Ile Met Gln Asp Lys Glu 
        35                  40                  45              


Lys Ile Arg Glu Lys Tyr Gly Pro Glu Trp Ala Arg Leu Pro Pro Ala 
    50                  55                  60                  


Gln Gln Asp Glu Ile Ile Asp Arg Cys Leu Val Gly Pro Arg Ala Pro 
65                  70                  75                  80  


Ala Pro Arg Asp Pro Gly Asp Ser Glu Glu Leu Thr Arg Phe Pro Gly 
                85                  90                  95      


Leu Arg Gly Pro Thr Gly Gln Lys Val Val Arg Phe Gly Asp Glu Asp 
            100                 105                 110         


Leu Thr Trp Gln Asp Glu His Ser Ala Pro Phe Ser Trp Glu Thr Lys 
        115                 120                 125             


Ser Gln Met Glu Phe Ser Ile Ser Ala Leu Ser Ile Gln Glu Pro Ser 
    130                 135                 140                 


Asn Gly Thr Ala Ala Ser Glu Pro Arg Pro Leu Ser Lys Ala Ser Gln 
145                 150                 155                 160 


Gly Ser Gln Ala Leu Lys Ser Ser Gln Gly Ser Arg Ser Ser Ser Leu 
                165                 170                 175     


Asp Ala Leu Gly Pro Thr Arg Lys Glu Glu Glu Ala Ser Phe Trp Lys 
            180                 185                 190         


Ile Asn Ala Glu Arg Ser Arg Gly Glu Gly Pro Glu Ala Glu Phe Gln 
        195                 200                 205             


Ser Leu Thr Pro Ser Gln Ile Lys Ser Met Glu Lys Gly Glu Lys Val 
    210                 215                 220                 


Leu Pro Pro Cys Tyr Arg Gln Glu Pro Ala Pro Lys Asp Arg Glu Ala 
225                 230                 235                 240 


Lys Val Glu Arg Pro Ser Thr Leu Arg Gln Glu Gln Arg Pro Leu Pro 
                245                 250                 255     


Asn Val Ser Thr Glu Arg Glu Arg Pro Gln Pro Val Gln Ala Phe Ser 
            260                 265                 270         


Ser Ala Leu His Glu Ala Ala Pro Ser Gln Leu Glu Gly Lys Leu Pro 
        275                 280                 285             


Ser Pro Asp Val Arg Gln Asp Asp Gly Glu Asp Thr Leu Phe Ser Glu 
    290                 295                 300                 


Pro Lys Phe Ala Gln Val Ser Ser Ser Asn Val Val Leu Lys Thr Gly 
305                 310                 315                 320 


Phe Asp Phe Leu Asp Asn Trp 
                325         


<210>  1763
<211>  197
<212>  PRT
<213>  Homo Sapiens

<400>  1763

Met Glu Phe Ser Ile Ser Ala Leu Ser Ile Gln Glu Pro Ser Asn Gly 
1               5                   10                  15      


Thr Ala Ala Ser Glu Pro Arg Pro Leu Ser Lys Ala Ser Gln Gly Ser 
            20                  25                  30          


Gln Ala Leu Lys Ser Ser Gln Gly Ser Arg Ser Ser Ser Leu Asp Ala 
        35                  40                  45              


Leu Gly Pro Thr Arg Lys Glu Glu Glu Ala Ser Phe Trp Lys Ile Asn 
    50                  55                  60                  


Ala Glu Arg Ser Arg Gly Glu Gly Pro Glu Ala Glu Phe Gln Ser Leu 
65                  70                  75                  80  


Thr Pro Ser Gln Ile Lys Ser Met Glu Lys Gly Glu Lys Val Leu Pro 
                85                  90                  95      


Pro Cys Tyr Arg Gln Glu Pro Ala Pro Lys Asp Arg Glu Ala Lys Val 
            100                 105                 110         


Glu Arg Pro Ser Thr Leu Arg Gln Glu Gln Arg Pro Leu Pro Asn Val 
        115                 120                 125             


Ser Thr Glu Arg Glu Arg Pro Gln Pro Val Gln Ala Phe Ser Ser Ala 
    130                 135                 140                 


Leu His Glu Ala Ala Pro Ser Gln Leu Glu Gly Lys Leu Pro Ser Pro 
145                 150                 155                 160 


Asp Val Arg Gln Asp Asp Gly Glu Asp Thr Leu Phe Ser Glu Pro Lys 
                165                 170                 175     


Phe Ala Gln Val Ser Ser Ser Asn Val Val Leu Lys Thr Gly Phe Asp 
            180                 185                 190         


Phe Leu Asp Asn Trp 
        195         


<210>  1764
<211>  110
<212>  PRT
<213>  Homo Sapiens

<400>  1764

Met Glu Lys Gly Glu Lys Val Leu Pro Pro Cys Tyr Arg Gln Glu Pro 
1               5                   10                  15      


Ala Pro Lys Asp Arg Glu Ala Lys Val Glu Arg Pro Ser Thr Leu Arg 
            20                  25                  30          


Gln Glu Gln Arg Pro Leu Pro Asn Val Ser Thr Glu Arg Glu Arg Pro 
        35                  40                  45              


Gln Pro Val Gln Ala Phe Ser Ser Ala Leu His Glu Ala Ala Pro Ser 
    50                  55                  60                  


Gln Leu Glu Gly Lys Leu Pro Ser Pro Asp Val Arg Gln Asp Asp Gly 
65                  70                  75                  80  


Glu Asp Thr Leu Phe Ser Glu Pro Lys Phe Ala Gln Val Ser Ser Ser 
                85                  90                  95      


Asn Val Val Leu Lys Thr Gly Phe Asp Phe Leu Asp Asn Trp 
            100                 105                 110 


<210>  1765
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  1765

Met Gln Asp Lys Glu Lys Ile Arg Glu Lys Tyr Gly Pro Glu Trp Ala 
1               5                   10                  15      


Arg Leu Pro Pro Ala Gln Gln Asp Glu Ile Ile Asp Arg Cys Leu Val 
            20                  25                  30          


Gly Pro Arg Ala Pro Ala Pro Arg Asp Pro Gly Asp Ser Glu Glu Leu 
        35                  40                  45              


Thr Arg Phe Pro Gly Leu Arg Gly Pro Thr Gly Gln Lys Val Val Arg 
    50                  55                  60                  


Phe Gly Asp Glu Asp Leu Thr Trp Gln Asp Glu His Ser Ala Pro Phe 
65                  70                  75                  80  


Ser Trp Glu Thr Lys Ser Gln Met Glu Phe Ser Ile Ser Ala Leu Ser 
                85                  90                  95      


Ile Gln Glu Pro Ser Asn Gly Thr Ala Ala Ser Glu Pro Arg Pro Leu 
            100                 105                 110         


Ser Lys Ala Ser Gln Gly Ser Gln Ala Leu Lys Ser Ser Gln Gly Ser 
        115                 120                 125             


Arg Ser Ser Ser Leu Asp Ala Leu Gly Pro Thr Arg Lys Glu Glu Glu 
    130                 135                 140                 


Ala Ser Phe Trp Lys Ile Asn Ala Glu Arg Ser Arg Gly Glu Gly Pro 
145                 150                 155                 160 


<210>  1766
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  1766

Met Asp Val Leu Phe Val Ala Ile Phe Ala Val Pro Leu Ile Leu Gly 
1               5                   10                  15      


Gln Glu Tyr Glu Asp Glu Glu Arg Leu Gly Glu Asp Glu Tyr Tyr Gln 
            20                  25                  30          


Val Val Tyr Tyr Tyr Thr Val Thr Pro Ser Tyr Asp Asp Phe Ser Ala 
        35                  40                  45              


Asp Phe Thr Ile Asp Tyr Ser Ile Phe Glu Ser Glu Asp Arg Leu Asn 
    50                  55                  60                  


Arg Leu Asp Lys Asp Ile Thr Glu Ala Ile Glu Thr Thr Ile Ser Leu 
65                  70                  75                  80  


Glu Thr Ala Arg Ala Asp His Pro Lys Pro Val Thr Val Lys Pro Val 
                85                  90                  95      


Thr Thr Glu Pro Ser Pro Asp Leu Asn Asp Ala Val Ser Ser Leu Arg 
            100                 105                 110         


Ser Pro Ile Pro Leu Leu Leu Ser Cys Ala Phe Val Gln Val Gly Met 
        115                 120                 125             


Tyr Phe Met 
    130     


<210>  1767
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  1767

Met Asp Val Leu Phe Val Ala Ile Phe Ala Val Pro Leu Ile Leu Gly 
1               5                   10                  15      


Gln Glu Tyr Glu Asp Glu Glu Arg Leu Gly Glu Asp Glu Tyr Tyr Gln 
            20                  25                  30          


Val Val Tyr Tyr Tyr Thr Val Thr Pro Ser Tyr Asp Asp Phe Ser Ala 
        35                  40                  45              


Asp Phe Thr Ile Asp Tyr Ser Ile Phe Glu Ser Glu Asp Arg Leu Asn 
    50                  55                  60                  


Arg Leu Asp Lys Asp Ile Thr Glu Ala Ile Glu Thr Thr Ile Ser Leu 
65                  70                  75                  80  


Glu Thr Ala Arg Ala Asp His Pro Lys Pro Val Thr Val Lys Pro Val 
                85                  90                  95      


Thr Thr Glu Pro Ser Pro Asp Leu Asn Asp Ala Val Ser Ser Leu Arg 
            100                 105                 110         


Ser Pro Ile Pro Leu Leu Leu Ser Cys Ala Phe Val Gln Val Gly Met 
        115                 120                 125             


Tyr Phe Met 
    130     


<210>  1768
<211>  121
<212>  PRT
<213>  Homo Sapiens

<400>  1768

Met Asp Val Leu Phe Val Ala Ile Phe Ala Val Pro Leu Ile Leu Gly 
1               5                   10                  15      


Gln Glu Tyr Glu Asp Glu Glu Arg Leu Gly Glu Asp Glu Tyr Tyr Gln 
            20                  25                  30          


Val Val Tyr Tyr Tyr Thr Val Thr Pro Ser Tyr Asp Asp Phe Ser Ala 
        35                  40                  45              


Asp Phe Thr Ile Asp Tyr Ser Ile Phe Glu Ser Glu Asp Arg Leu Asn 
    50                  55                  60                  


Arg Leu Asp Lys Asp Ile Thr Glu Ala Ile Glu Thr Thr Ile Ser Leu 
65                  70                  75                  80  


Glu Thr Ala Arg Ala Asp His Pro Lys Pro Val Thr Val Lys Pro Val 
                85                  90                  95      


Thr Thr Glu Pro Val Glu Glu Gly Cys Tyr Asp Ser Leu Asp Gly Ser 
            100                 105                 110         


Leu Ala Arg Gly Asn Trp Lys Ile Lys 
        115                 120     


<210>  1769
<211>  341
<212>  PRT
<213>  Homo Sapiens

<400>  1769

Met Val Pro Ala Ala Gly Ala Leu Leu Trp Val Leu Leu Leu Asn Leu 
1               5                   10                  15      


Gly Pro Arg Ala Ala Gly Ala Gln Gly Leu Thr Gln Thr Pro Thr Glu 
            20                  25                  30          


Met Gln Arg Val Ser Leu Arg Phe Gly Gly Pro Met Thr Arg Ser Tyr 
        35                  40                  45              


Arg Ser Thr Ala Arg Thr Gly Leu Pro Arg Lys Thr Arg Ile Ile Leu 
    50                  55                  60                  


Glu Asp Glu Asn Asp Ala Met Ala Asp Ala Asp Arg Leu Ala Gly Pro 
65                  70                  75                  80  


Ala Ala Ala Glu Leu Leu Ala Ala Thr Val Ser Thr Gly Phe Ser Arg 
                85                  90                  95      


Ser Ser Ala Ile Asn Glu Glu Asp Gly Ser Ser Glu Glu Gly Val Val 
            100                 105                 110         


Ile Asn Ala Gly Lys Asp Ser Thr Ser Arg Glu Leu Pro Ser Ala Thr 
        115                 120                 125             


Pro Asn Thr Ala Gly Ser Ser Ser Thr Arg Phe Ile Ala Asn Ser Gln 
    130                 135                 140                 


Glu Pro Glu Ile Arg Leu Thr Ser Ser Leu Pro Arg Ser Pro Gly Arg 
145                 150                 155                 160 


Ser Thr Glu Asp Leu Pro Gly Ser Gln Ala Thr Leu Ser Gln Trp Ser 
                165                 170                 175     


Thr Pro Gly Ser Thr Pro Ser Arg Trp Pro Ser Pro Ser Pro Thr Ala 
            180                 185                 190         


Met Pro Ser Pro Glu Asp Leu Arg Leu Val Leu Met Pro Trp Gly Pro 
        195                 200                 205             


Trp His Cys His Cys Lys Ser Gly Thr Met Ser Arg Ser Arg Ser Gly 
    210                 215                 220                 


Lys Leu His Gly Leu Ser Gly Arg Leu Arg Val Gly Ala Leu Ser Gln 
225                 230                 235                 240 


Leu Arg Thr Glu His Lys Pro Cys Thr Tyr Gln Gln Cys Pro Cys Asn 
                245                 250                 255     


Arg Leu Arg Glu Glu Cys Pro Leu Asp Thr Ser Leu Cys Thr Asp Thr 
            260                 265                 270         


Asn Cys Ala Ser Gln Ser Thr Thr Ser Thr Arg Thr Thr Thr Thr Pro 
        275                 280                 285             


Phe Pro Thr Ile His Leu Arg Ser Ser Pro Ser Leu Pro Pro Ala Ser 
    290                 295                 300                 


Pro Cys Pro Ala Leu Ala Phe Trp Lys Arg Val Arg Ile Gly Leu Glu 
305                 310                 315                 320 


Asp Ile Trp Asn Ser Leu Ser Ser Val Phe Thr Glu Met Gln Pro Ile 
                325                 330                 335     


Asp Arg Asn Gln Arg 
            340     


<210>  1770
<211>  221
<212>  PRT
<213>  Homo Sapiens

<400>  1770

Met Glu Gly Pro Arg Gly Trp Leu Val Leu Cys Val Leu Ala Ile Ser 
1               5                   10                  15      


Leu Ala Ser Met Val Thr Glu Asp Leu Cys Arg Ala Pro Asp Gly Lys 
            20                  25                  30          


Lys Gly Glu Ala Gly Arg Pro Gly Arg Arg Gly Arg Pro Gly Leu Lys 
        35                  40                  45              


Gly Glu Gln Gly Glu Pro Gly Ala Pro Gly Ile Arg Thr Gly Ile Gln 
    50                  55                  60                  


Gly Leu Lys Gly Asp Gln Gly Glu Pro Gly Pro Ser Gly Asn Pro Gly 
65                  70                  75                  80  


Lys Val Gly Tyr Pro Gly Pro Ser Gly Pro Leu Gly Ala Arg Gly Ile 
                85                  90                  95      


Pro Gly Ile Lys Gly Thr Lys Gly Ser Pro Gly Asn Ile Lys Asp Gln 
            100                 105                 110         


Pro Arg Pro Ala Phe Ser Ala Ile Arg Arg Asn Pro Pro Met Gly Gly 
        115                 120                 125             


Asn Val Val Ile Phe Asp Thr Val Ile Thr Asn Gln Glu Glu Pro Tyr 
    130                 135                 140                 


Gln Asn His Ser Gly Arg Phe Val Cys Thr Val Pro Gly Tyr Tyr Tyr 
145                 150                 155                 160 


Phe Thr Phe Gln Val Leu Ser Gln Trp Glu Ile Cys Leu Ser Ile Val 
                165                 170                 175     


Ser Ser Ser Arg Gly Gln Val Arg Arg Ser Leu Gly Phe Cys Asp Thr 
            180                 185                 190         


Thr Asn Lys Gly Leu Phe Gln Val Val Ser Gly Gly Met Val Leu Gln 
        195                 200                 205             


Leu Gln Gln Gly Asp Gln Val Trp Val Glu Lys Asp Pro 
    210                 215                 220     


<210>  1771
<211>  245
<212>  PRT
<213>  Homo Sapiens

<400>  1771

Met Glu Gly Pro Arg Gly Trp Leu Val Leu Cys Val Leu Ala Ile Ser 
1               5                   10                  15      


Leu Ala Ser Met Val Thr Glu Asp Leu Cys Arg Ala Pro Asp Gly Lys 
            20                  25                  30          


Lys Gly Glu Ala Gly Arg Pro Gly Arg Arg Gly Arg Pro Gly Leu Lys 
        35                  40                  45              


Gly Glu Gln Gly Glu Pro Gly Ala Pro Gly Ile Arg Thr Gly Ile Gln 
    50                  55                  60                  


Gly Leu Lys Gly Asp Gln Gly Glu Pro Gly Pro Ser Gly Asn Pro Gly 
65                  70                  75                  80  


Lys Val Gly Tyr Pro Gly Pro Ser Gly Pro Leu Gly Ala Arg Gly Ile 
                85                  90                  95      


Pro Gly Ile Lys Gly Thr Lys Gly Ser Pro Gly Asn Ile Lys Asp Gln 
            100                 105                 110         


Pro Arg Pro Ala Phe Ser Ala Ile Arg Arg Asn Pro Pro Met Gly Gly 
        115                 120                 125             


Asn Val Val Ile Phe Asp Thr Val Ile Thr Asn Gln Glu Glu Pro Tyr 
    130                 135                 140                 


Gln Asn His Ser Gly Arg Phe Val Cys Thr Val Pro Gly Tyr Tyr Tyr 
145                 150                 155                 160 


Phe Thr Phe Gln Val Leu Ser Gln Trp Glu Ile Cys Leu Ser Ile Val 
                165                 170                 175     


Ser Ser Ser Arg Gly Gln Val Arg Arg Ser Leu Gly Phe Cys Asp Thr 
            180                 185                 190         


Thr Asn Lys Gly Leu Phe Gln Val Val Ser Gly Gly Met Val Leu Gln 
        195                 200                 205             


Leu Gln Gln Gly Asp Gln Val Trp Val Glu Lys Asp Pro Lys Lys Gly 
    210                 215                 220                 


His Ile Tyr Gln Gly Ser Glu Ala Asp Ser Val Phe Ser Gly Phe Leu 
225                 230                 235                 240 


Ile Phe Pro Ser Ala 
                245 


<210>  1772
<211>  245
<212>  PRT
<213>  Homo Sapiens

<400>  1772

Met Glu Gly Pro Arg Gly Trp Leu Val Leu Cys Val Leu Ala Ile Ser 
1               5                   10                  15      


Leu Ala Ser Met Val Thr Glu Asp Leu Cys Arg Ala Pro Asp Gly Lys 
            20                  25                  30          


Lys Gly Glu Ala Gly Arg Pro Gly Arg Arg Gly Arg Pro Gly Leu Lys 
        35                  40                  45              


Gly Glu Gln Gly Glu Pro Gly Ala Pro Gly Ile Arg Thr Gly Ile Gln 
    50                  55                  60                  


Gly Leu Lys Gly Asp Gln Gly Glu Pro Gly Pro Ser Gly Asn Pro Gly 
65                  70                  75                  80  


Lys Val Gly Tyr Pro Gly Pro Ser Gly Pro Leu Gly Ala Arg Gly Ile 
                85                  90                  95      


Pro Gly Ile Lys Gly Thr Lys Gly Ser Pro Gly Asn Ile Lys Asp Gln 
            100                 105                 110         


Pro Arg Pro Ala Phe Ser Ala Ile Arg Arg Asn Pro Pro Met Gly Gly 
        115                 120                 125             


Asn Val Val Ile Phe Asp Thr Val Ile Thr Asn Gln Glu Glu Pro Tyr 
    130                 135                 140                 


Gln Asn His Ser Gly Arg Phe Val Cys Thr Val Pro Gly Tyr Tyr Tyr 
145                 150                 155                 160 


Phe Thr Phe Gln Val Leu Ser Gln Trp Glu Ile Cys Leu Ser Ile Val 
                165                 170                 175     


Ser Ser Ser Arg Gly Gln Val Arg Arg Ser Leu Gly Phe Cys Asp Thr 
            180                 185                 190         


Thr Asn Lys Gly Leu Phe Gln Val Val Ser Gly Gly Met Val Leu Gln 
        195                 200                 205             


Leu Gln Gln Gly Asp Gln Val Trp Val Glu Lys Asp Pro Lys Lys Gly 
    210                 215                 220                 


His Ile Tyr Gln Gly Ser Glu Ala Asp Ser Val Phe Ser Gly Phe Leu 
225                 230                 235                 240 


Ile Phe Pro Ser Ala 
                245 


<210>  1773
<211>  153
<212>  PRT
<213>  Homo Sapiens

<400>  1773

Met Lys Ile Pro Trp Gly Ser Ile Pro Val Leu Met Leu Leu Leu Leu 
1               5                   10                  15      


Leu Gly Leu Ile Asp Ile Ser Gln Ala Gln Leu Ser Cys Thr Gly Pro 
            20                  25                  30          


Pro Ala Ile Pro Gly Ile Pro Gly Ile Pro Gly Thr Pro Gly Pro Asp 
        35                  40                  45              


Gly Gln Pro Gly Thr Pro Gly Ile Lys Gly Glu Lys Gly Leu Pro Gly 
    50                  55                  60                  


Leu Ala Gly Asp His Gly Glu Phe Gly Glu Lys Gly Asp Pro Gly Ile 
65                  70                  75                  80  


Pro Gly Asn Pro Gly Lys Val Gly Pro Lys Gly Pro Met Gly Pro Lys 
                85                  90                  95      


Gly Gly Pro Gly Ala Pro Gly Ala Pro Gly Pro Lys Gly Glu Ser Gly 
            100                 105                 110         


Asp Tyr Lys Ala Thr Gln Lys Ile Ala Phe Ser Ala Thr Arg Thr Ile 
        115                 120                 125             


Asn Val Pro Leu Arg Arg Asp Gln Thr Ile Arg Phe Asp His Val Ile 
    130                 135                 140                 


Thr Asn Met Asn Asn Asn Tyr Glu Pro 
145                 150             


<210>  1774
<211>  229
<212>  PRT
<213>  Homo Sapiens

<400>  1774

Met Lys Ile Pro Trp Gly Ser Ile Pro Val Leu Met Leu Leu Leu Leu 
1               5                   10                  15      


Leu Gly Leu Ile Asp Ile Ser Gln Ala Gln Leu Ser Cys Thr Gly Pro 
            20                  25                  30          


Pro Ala Ile Pro Gly Ile Pro Gly Ile Pro Gly Thr Pro Gly Pro Asp 
        35                  40                  45              


Gly Gln Pro Gly Thr Pro Gly Ile Lys Gly Glu Lys Gly Leu Pro Gly 
    50                  55                  60                  


Leu Ala Gly Asp His Gly Glu Phe Gly Glu Lys Gly Asp Pro Gly Ile 
65                  70                  75                  80  


Pro Gly Asn Pro Gly Lys Val Gly Pro Lys Gly Pro Met Gly Pro Lys 
                85                  90                  95      


Gly Gly Pro Gly Ala Pro Gly Ala Pro Gly Pro Lys Gly Glu Ser Gly 
            100                 105                 110         


Asp Tyr Lys Ala Thr Gln Lys Ile Ala Phe Ser Ala Thr Arg Thr Ile 
        115                 120                 125             


Asn Val Pro Leu Arg Arg Asp Gln Thr Ile Arg Phe Asp His Val Ile 
    130                 135                 140                 


Thr Asn Met Asn Asn Asn Tyr Glu Pro Arg Ser Gly Lys Phe Thr Cys 
145                 150                 155                 160 


Lys Val Pro Gly Leu Tyr Tyr Phe Thr Tyr His Ala Ser Ser Arg Gly 
                165                 170                 175     


Asn Leu Cys Val Asn Leu Met Arg Gly Arg Glu Arg Ala Gln Lys Val 
            180                 185                 190         


Val Thr Phe Cys Asp Tyr Ala Tyr Asn Thr Phe Gln Val Thr Thr Gly 
        195                 200                 205             


Gly Met Val Leu Lys Leu Glu Gln Gly Glu Asn Val Phe Leu Gln Ala 
    210                 215                 220                 


Thr Asp Lys Asn Ser 
225                 


<210>  1775
<211>  251
<212>  PRT
<213>  Homo Sapiens

<400>  1775

Met Lys Ile Pro Trp Gly Ser Ile Pro Val Leu Met Leu Leu Leu Leu 
1               5                   10                  15      


Leu Gly Leu Ile Asp Ile Ser Gln Ala Gln Leu Ser Cys Thr Gly Pro 
            20                  25                  30          


Pro Ala Ile Pro Gly Ile Pro Gly Ile Pro Gly Thr Pro Gly Pro Asp 
        35                  40                  45              


Gly Gln Pro Gly Thr Pro Gly Ile Lys Gly Glu Lys Gly Leu Pro Gly 
    50                  55                  60                  


Leu Ala Gly Asp His Gly Glu Phe Gly Glu Lys Gly Asp Pro Gly Ile 
65                  70                  75                  80  


Pro Gly Asn Pro Gly Lys Val Gly Pro Lys Gly Pro Met Gly Pro Lys 
                85                  90                  95      


Gly Gly Pro Gly Ala Pro Gly Ala Pro Gly Pro Lys Gly Glu Ser Gly 
            100                 105                 110         


Asp Tyr Lys Ala Thr Gln Lys Ile Ala Phe Ser Ala Thr Arg Thr Ile 
        115                 120                 125             


Asn Val Pro Leu Arg Arg Asp Gln Thr Ile Arg Phe Asp His Val Ile 
    130                 135                 140                 


Thr Asn Met Asn Asn Asn Tyr Glu Pro Arg Ser Gly Lys Phe Thr Cys 
145                 150                 155                 160 


Lys Val Pro Gly Leu Tyr Tyr Phe Thr Tyr His Ala Ser Ser Arg Gly 
                165                 170                 175     


Asn Leu Cys Val Asn Leu Met Arg Gly Arg Glu Arg Ala Gln Lys Val 
            180                 185                 190         


Val Thr Phe Cys Asp Tyr Ala Tyr Asn Thr Phe Gln Val Thr Thr Gly 
        195                 200                 205             


Gly Met Val Leu Lys Leu Glu Gln Gly Glu Asn Val Phe Leu Gln Ala 
    210                 215                 220                 


Thr Asp Lys Asn Ser Leu Leu Gly Met Glu Gly Ala Asn Ser Ile Phe 
225                 230                 235                 240 


Ser Gly Phe Leu Leu Phe Pro Asp Met Glu Ala 
                245                 250     


<210>  1776
<211>  253
<212>  PRT
<213>  Homo Sapiens

<400>  1776

Met Met Met Lys Ile Pro Trp Gly Ser Ile Pro Val Leu Met Leu Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Ile Asp Ile Ser Gln Ala Gln Leu Ser Cys Thr 
            20                  25                  30          


Gly Pro Pro Ala Ile Pro Gly Ile Pro Gly Ile Pro Gly Thr Pro Gly 
        35                  40                  45              


Pro Asp Gly Gln Pro Gly Thr Pro Gly Ile Lys Gly Glu Lys Gly Leu 
    50                  55                  60                  


Pro Gly Leu Ala Gly Asp His Gly Glu Phe Gly Glu Lys Gly Asp Pro 
65                  70                  75                  80  


Gly Ile Pro Gly Asn Pro Gly Lys Val Gly Pro Lys Gly Pro Met Gly 
                85                  90                  95      


Pro Lys Gly Gly Pro Gly Ala Pro Gly Ala Pro Gly Pro Lys Gly Glu 
            100                 105                 110         


Ser Gly Asp Tyr Lys Ala Thr Gln Lys Ile Ala Phe Ser Ala Thr Arg 
        115                 120                 125             


Thr Ile Asn Val Pro Leu Arg Arg Asp Gln Thr Ile Arg Phe Asp His 
    130                 135                 140                 


Val Ile Thr Asn Met Asn Asn Asn Tyr Glu Pro Arg Ser Gly Lys Phe 
145                 150                 155                 160 


Thr Cys Lys Val Pro Gly Leu Tyr Tyr Phe Thr Tyr His Ala Ser Ser 
                165                 170                 175     


Arg Gly Asn Leu Cys Val Asn Leu Met Arg Gly Arg Glu Arg Ala Gln 
            180                 185                 190         


Lys Val Val Thr Phe Cys Asp Tyr Ala Tyr Asn Thr Phe Gln Val Thr 
        195                 200                 205             


Thr Gly Gly Met Val Leu Lys Leu Glu Gln Gly Glu Asn Val Phe Leu 
    210                 215                 220                 


Gln Ala Thr Asp Lys Asn Ser Leu Leu Gly Met Glu Gly Ala Asn Ser 
225                 230                 235                 240 


Ile Phe Ser Gly Phe Leu Leu Phe Pro Asp Met Glu Ala 
                245                 250             


<210>  1777
<211>  245
<212>  PRT
<213>  Homo Sapiens

<400>  1777

Met Asp Val Gly Pro Ser Ser Leu Pro His Leu Gly Leu Lys Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Pro Leu Arg Gly Gln Ala Asn Thr Gly Cys 
            20                  25                  30          


Tyr Gly Ile Pro Gly Met Pro Gly Leu Pro Gly Ala Pro Gly Lys Asp 
        35                  40                  45              


Gly Tyr Asp Gly Leu Pro Gly Pro Lys Gly Glu Pro Gly Ile Pro Ala 
    50                  55                  60                  


Ile Pro Gly Ile Arg Gly Pro Lys Gly Gln Lys Gly Glu Pro Gly Leu 
65                  70                  75                  80  


Pro Gly His Pro Gly Lys Asn Gly Pro Met Gly Pro Pro Gly Met Pro 
                85                  90                  95      


Gly Val Pro Gly Pro Met Gly Ile Pro Gly Glu Pro Gly Glu Glu Gly 
            100                 105                 110         


Arg Tyr Lys Gln Lys Phe Gln Ser Val Phe Thr Val Thr Arg Gln Thr 
        115                 120                 125             


His Gln Pro Pro Ala Pro Asn Ser Leu Ile Arg Phe Asn Ala Val Leu 
    130                 135                 140                 


Thr Asn Pro Gln Gly Asp Tyr Asp Thr Ser Thr Gly Lys Phe Thr Cys 
145                 150                 155                 160 


Lys Val Pro Gly Leu Tyr Tyr Phe Val Tyr His Ala Ser His Thr Ala 
                165                 170                 175     


Asn Leu Cys Val Leu Leu Tyr Arg Ser Gly Val Lys Val Val Thr Phe 
            180                 185                 190         


Cys Gly His Thr Ser Lys Thr Asn Gln Val Asn Ser Gly Gly Val Leu 
        195                 200                 205             


Leu Arg Leu Gln Val Gly Glu Glu Val Trp Leu Ala Val Asn Asp Tyr 
    210                 215                 220                 


Tyr Asp Met Val Gly Ile Gln Gly Ser Asp Ser Val Phe Ser Gly Phe 
225                 230                 235                 240 


Leu Leu Phe Pro Asp 
                245 


<210>  1778
<211>  245
<212>  PRT
<213>  Homo Sapiens

<400>  1778

Met Asp Val Gly Pro Ser Ser Leu Pro His Leu Gly Leu Lys Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Pro Leu Arg Gly Gln Ala Asn Thr Gly Cys 
            20                  25                  30          


Tyr Gly Ile Pro Gly Met Pro Gly Leu Pro Gly Ala Pro Gly Lys Asp 
        35                  40                  45              


Gly Tyr Asp Gly Leu Pro Gly Pro Lys Gly Glu Pro Gly Ile Pro Ala 
    50                  55                  60                  


Ile Pro Gly Ile Arg Gly Pro Lys Gly Gln Lys Gly Glu Pro Gly Leu 
65                  70                  75                  80  


Pro Gly His Pro Gly Lys Asn Gly Pro Met Gly Pro Pro Gly Met Pro 
                85                  90                  95      


Gly Val Pro Gly Pro Met Gly Ile Pro Gly Glu Pro Gly Glu Glu Gly 
            100                 105                 110         


Arg Tyr Lys Gln Lys Phe Gln Ser Val Phe Thr Val Thr Arg Gln Thr 
        115                 120                 125             


His Gln Pro Pro Ala Pro Asn Ser Leu Ile Arg Phe Asn Ala Val Leu 
    130                 135                 140                 


Thr Asn Pro Gln Gly Asp Tyr Asp Thr Ser Thr Gly Lys Phe Thr Cys 
145                 150                 155                 160 


Lys Val Pro Gly Leu Tyr Tyr Phe Val Tyr His Ala Ser His Thr Ala 
                165                 170                 175     


Asn Leu Cys Val Leu Leu Tyr Arg Ser Gly Val Lys Val Val Thr Phe 
            180                 185                 190         


Cys Gly His Thr Ser Lys Thr Asn Gln Val Asn Ser Gly Gly Val Leu 
        195                 200                 205             


Leu Arg Leu Gln Val Gly Glu Glu Val Trp Leu Ala Val Asn Asp Tyr 
    210                 215                 220                 


Tyr Asp Met Val Gly Ile Gln Gly Ser Asp Ser Val Phe Ser Gly Phe 
225                 230                 235                 240 


Leu Leu Phe Pro Asp 
                245 


<210>  1779
<211>  245
<212>  PRT
<213>  Homo Sapiens

<400>  1779

Met Asp Val Gly Pro Ser Ser Leu Pro His Leu Gly Leu Lys Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Pro Leu Arg Gly Gln Ala Asn Thr Gly Cys 
            20                  25                  30          


Tyr Gly Ile Pro Gly Met Pro Gly Leu Pro Gly Ala Pro Gly Lys Asp 
        35                  40                  45              


Gly Tyr Asp Gly Leu Pro Gly Pro Lys Gly Glu Pro Gly Ile Pro Ala 
    50                  55                  60                  


Ile Pro Gly Ile Arg Gly Pro Lys Gly Gln Lys Gly Glu Pro Gly Leu 
65                  70                  75                  80  


Pro Gly His Pro Gly Lys Asn Gly Pro Met Gly Pro Pro Gly Met Pro 
                85                  90                  95      


Gly Val Pro Gly Pro Met Gly Ile Pro Gly Glu Pro Gly Glu Glu Gly 
            100                 105                 110         


Arg Tyr Lys Gln Lys Phe Gln Ser Val Phe Thr Val Thr Arg Gln Thr 
        115                 120                 125             


His Gln Pro Pro Ala Pro Asn Ser Leu Ile Arg Phe Asn Ala Val Leu 
    130                 135                 140                 


Thr Asn Pro Gln Gly Asp Tyr Asp Thr Ser Thr Gly Lys Phe Thr Cys 
145                 150                 155                 160 


Lys Val Pro Gly Leu Tyr Tyr Phe Val Tyr His Ala Ser His Thr Ala 
                165                 170                 175     


Asn Leu Cys Val Leu Leu Tyr Arg Ser Gly Val Lys Val Val Thr Phe 
            180                 185                 190         


Cys Gly His Thr Ser Lys Thr Asn Gln Val Asn Ser Gly Gly Val Leu 
        195                 200                 205             


Leu Arg Leu Gln Val Gly Glu Glu Val Trp Leu Ala Val Asn Asp Tyr 
    210                 215                 220                 


Tyr Asp Met Val Gly Ile Gln Gly Ser Asp Ser Val Phe Ser Gly Phe 
225                 230                 235                 240 


Leu Leu Phe Pro Asp 
                245 


<210>  1780
<211>  258
<212>  PRT
<213>  Homo Sapiens

<400>  1780

Met Leu Leu Val Leu Val Val Leu Ile Pro Val Leu Val Ser Ser Gly 
1               5                   10                  15      


Gly Pro Glu Gly His Tyr Glu Met Leu Gly Thr Cys Arg Met Val Cys 
            20                  25                  30          


Asp Pro Tyr Pro Ala Arg Gly Pro Gly Ala Gly Ala Arg Thr Asp Gly 
        35                  40                  45              


Gly Asp Ala Leu Ser Glu Gln Ser Gly Ala Pro Pro Pro Ser Thr Leu 
    50                  55                  60                  


Val Gln Gly Pro Gln Gly Lys Pro Gly Arg Thr Gly Lys Pro Gly Pro 
65                  70                  75                  80  


Pro Gly Pro Pro Gly Asp Pro Gly Pro Pro Gly Pro Val Gly Pro Pro 
                85                  90                  95      


Gly Glu Lys Gly Glu Pro Gly Lys Pro Gly Pro Pro Gly Leu Pro Gly 
            100                 105                 110         


Ala Gly Gly Ser Gly Ala Ile Ser Thr Ala Thr Tyr Thr Thr Val Pro 
        115                 120                 125             


Arg Val Ala Phe Tyr Ala Gly Leu Lys Asn Pro His Glu Gly Tyr Glu 
    130                 135                 140                 


Val Leu Lys Phe Asp Asp Val Val Thr Asn Leu Gly Asn Asn Tyr Asp 
145                 150                 155                 160 


Ala Ala Ser Gly Lys Phe Thr Cys Asn Ile Pro Gly Thr Tyr Phe Phe 
                165                 170                 175     


Thr Tyr His Val Leu Met Arg Gly Gly Asp Gly Thr Ser Met Trp Ala 
            180                 185                 190         


Asp Leu Cys Lys Asn Gly Gln Val Arg Ala Ser Ala Ile Ala Gln Asp 
        195                 200                 205             


Ala Asp Gln Asn Tyr Asp Tyr Ala Ser Asn Ser Val Ile Leu His Leu 
    210                 215                 220                 


Asp Ala Gly Asp Glu Val Phe Ile Lys Leu Asp Gly Gly Lys Ala His 
225                 230                 235                 240 


Gly Gly Asn Ser Asn Lys Tyr Ser Thr Phe Ser Gly Phe Ile Ile Tyr 
                245                 250                 255     


Ser Asp 
        


<210>  1781
<211>  287
<212>  PRT
<213>  Homo Sapiens

<400>  1781

Met Ala Leu Gly Leu Leu Ile Ala Val Pro Leu Leu Leu Gln Ala Ala 
1               5                   10                  15      


Pro Arg Gly Ala Ala His Tyr Glu Met Met Gly Thr Cys Arg Met Ile 
            20                  25                  30          


Cys Asp Pro Tyr Thr Ala Ala Pro Gly Gly Glu Pro Pro Gly Ala Lys 
        35                  40                  45              


Ala Gln Pro Pro Gly Pro Ser Thr Ala Ala Leu Glu Val Met Gln Asp 
    50                  55                  60                  


Leu Ser Ala Asn Pro Pro Pro Pro Phe Ile Gln Gly Pro Lys Gly Asp 
65                  70                  75                  80  


Pro Gly Arg Pro Gly Lys Pro Gly Pro Arg Gly Pro Pro Gly Glu Pro 
                85                  90                  95      


Gly Pro Pro Gly Pro Arg Gly Pro Pro Gly Glu Lys Gly Asp Ser Gly 
            100                 105                 110         


Arg Pro Gly Leu Pro Gly Leu Gln Leu Thr Ala Gly Thr Ala Ser Gly 
        115                 120                 125             


Val Gly Val Val Gly Gly Gly Ala Gly Val Gly Gly Asp Ser Glu Gly 
    130                 135                 140                 


Glu Val Thr Ser Ala Leu Ser Ala Thr Phe Ser Gly Pro Lys Ile Ala 
145                 150                 155                 160 


Phe Tyr Val Gly Leu Lys Ser Pro His Glu Gly Tyr Glu Val Leu Lys 
                165                 170                 175     


Phe Asp Asp Val Val Thr Asn Leu Gly Asn His Tyr Asp Pro Thr Thr 
            180                 185                 190         


Gly Lys Phe Ser Cys Gln Val Arg Gly Ile Tyr Phe Phe Thr Tyr His 
        195                 200                 205             


Ile Leu Met Arg Gly Gly Asp Gly Thr Ser Met Trp Ala Asp Leu Cys 
    210                 215                 220                 


Lys Asn Gly Gln Val Arg Ala Ser Ala Ile Ala Gln Asp Ala Asp Gln 
225                 230                 235                 240 


Asn Tyr Asp Tyr Ala Ser Asn Ser Val Val Leu His Leu Asp Ser Gly 
                245                 250                 255     


Asp Glu Val Tyr Val Lys Leu Asp Gly Gly Lys Ala His Gly Gly Asn 
            260                 265                 270         


Asn Asn Lys Tyr Ser Thr Phe Ser Gly Phe Leu Leu Tyr Pro Asp 
        275                 280                 285         


<210>  1782
<211>  255
<212>  PRT
<213>  Homo Sapiens

<400>  1782

Met Val Leu Leu Leu Val Ile Leu Ile Pro Val Leu Val Ser Ser Ala 
1               5                   10                  15      


Gly Thr Ser Ala His Tyr Glu Met Leu Gly Thr Cys Arg Met Val Cys 
            20                  25                  30          


Asp Pro Tyr Gly Gly Thr Lys Ala Pro Ser Thr Ala Ala Thr Pro Asp 
        35                  40                  45              


Arg Gly Leu Met Gln Ser Leu Pro Thr Phe Ile Gln Gly Pro Lys Gly 
    50                  55                  60                  


Glu Ala Gly Arg Pro Gly Lys Ala Gly Pro Arg Gly Pro Pro Gly Glu 
65                  70                  75                  80  


Pro Gly Pro Pro Gly Pro Met Gly Pro Pro Gly Glu Lys Gly Glu Pro 
                85                  90                  95      


Gly Arg Gln Gly Leu Pro Gly Pro Pro Gly Ala Pro Gly Leu Asn Ala 
            100                 105                 110         


Ala Gly Ala Ile Ser Ala Ala Thr Tyr Ser Thr Val Pro Lys Ile Ala 
        115                 120                 125             


Phe Tyr Ala Gly Leu Lys Arg Gln His Glu Gly Tyr Glu Val Leu Lys 
    130                 135                 140                 


Phe Asp Asp Val Val Thr Asn Leu Gly Asn His Tyr Asp Pro Thr Thr 
145                 150                 155                 160 


Gly Lys Phe Thr Cys Ser Ile Pro Gly Ile Tyr Phe Phe Thr Tyr His 
                165                 170                 175     


Val Leu Met Arg Gly Gly Asp Gly Thr Ser Met Trp Ala Asp Leu Cys 
            180                 185                 190         


Lys Asn Asn Gln Val Arg Ala Ser Ala Ile Ala Gln Asp Ala Asp Gln 
        195                 200                 205             


Asn Tyr Asp Tyr Ala Ser Asn Ser Val Val Leu His Leu Glu Pro Gly 
    210                 215                 220                 


Asp Glu Val Tyr Ile Lys Leu Asp Gly Gly Lys Ala His Gly Gly Asn 
225                 230                 235                 240 


Asn Asn Lys Tyr Ser Thr Phe Ser Gly Phe Ile Ile Tyr Ala Asp 
                245                 250                 255 


<210>  1783
<211>  213
<212>  PRT
<213>  Homo Sapiens

<400>  1783

Met Val Leu Leu Leu Val Ile Leu Ile Pro Val Leu Val Ser Ser Ala 
1               5                   10                  15      


Gly Thr Ser Ala His Tyr Glu Met Leu Gly Thr Cys Arg Met Val Cys 
            20                  25                  30          


Asp Pro Tyr Gly Gly Thr Lys Ala Pro Ser Thr Ala Ala Thr Pro Asp 
        35                  40                  45              


Arg Gly Leu Met Gln Ser Leu Pro Thr Phe Ile Gln Gly Pro Pro Gly 
    50                  55                  60                  


Ala Pro Gly Leu Asn Ala Ala Gly Ala Ile Ser Ala Ala Thr Tyr Ser 
65                  70                  75                  80  


Thr Val Pro Lys Ile Ala Phe Tyr Ala Gly Leu Lys Arg Gln His Glu 
                85                  90                  95      


Gly Tyr Glu Val Leu Lys Phe Asp Asp Val Val Thr Asn Leu Gly Asn 
            100                 105                 110         


His Tyr Asp Pro Thr Thr Gly Lys Phe Thr Cys Ser Ile Pro Gly Ile 
        115                 120                 125             


Tyr Phe Phe Thr Tyr His Val Leu Met Arg Gly Gly Asp Gly Thr Ser 
    130                 135                 140                 


Met Trp Ala Asp Leu Cys Lys Asn Asn Gln Val Arg Ala Ser Ala Ile 
145                 150                 155                 160 


Ala Gln Asp Ala Asp Gln Asn Tyr Asp Tyr Ala Ser Asn Ser Val Val 
                165                 170                 175     


Leu His Leu Glu Pro Gly Asp Glu Val Tyr Ile Lys Leu Asp Gly Gly 
            180                 185                 190         


Lys Ala His Gly Gly Asn Asn Asn Lys Tyr Ser Thr Phe Ser Gly Phe 
        195                 200                 205             


Ile Ile Tyr Ala Asp 
    210             


<210>  1784
<211>  238
<212>  PRT
<213>  Homo Sapiens

<400>  1784

Met Val Leu Leu Leu Leu Val Ala Ile Pro Leu Leu Val His Ser Ser 
1               5                   10                  15      


Arg Gly Pro Ala His Tyr Glu Met Leu Gly Arg Cys Arg Met Val Cys 
            20                  25                  30          


Asp Pro His Gly Pro Arg Gly Pro Gly Pro Asp Gly Ala Pro Ala Ser 
        35                  40                  45              


Val Pro Pro Phe Pro Pro Gly Ala Lys Gly Glu Val Gly Arg Arg Gly 
    50                  55                  60                  


Lys Ala Gly Leu Arg Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly Pro 
65                  70                  75                  80  


Pro Gly Glu Pro Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Pro Gly 
                85                  90                  95      


Pro Gly Gly Val Ala Pro Ala Ala Gly Tyr Val Pro Arg Ile Ala Phe 
            100                 105                 110         


Tyr Ala Gly Leu Arg Arg Pro His Glu Gly Tyr Glu Val Leu Arg Phe 
        115                 120                 125             


Asp Asp Val Val Thr Asn Val Gly Asn Ala Tyr Glu Ala Ala Ser Gly 
    130                 135                 140                 


Lys Phe Thr Cys Pro Met Pro Gly Val Tyr Phe Phe Ala Tyr His Val 
145                 150                 155                 160 


Leu Met Arg Gly Gly Asp Gly Thr Ser Met Trp Ala Asp Leu Met Lys 
                165                 170                 175     


Asn Gly Gln Val Arg Ala Ser Ala Ile Ala Gln Asp Ala Asp Gln Asn 
            180                 185                 190         


Tyr Asp Tyr Ala Ser Asn Ser Val Ile Leu His Leu Asp Val Gly Asp 
        195                 200                 205             


Glu Val Phe Ile Lys Leu Asp Gly Gly Lys Val His Gly Gly Asn Thr 
    210                 215                 220                 


Asn Lys Tyr Ser Thr Phe Ser Gly Phe Ile Ile Tyr Pro Asp 
225                 230                 235             


<210>  1785
<211>  281
<212>  PRT
<213>  Homo Sapiens

<400>  1785

Met Gly Ser Arg Gly Gln Gly Leu Leu Leu Ala Tyr Cys Leu Leu Leu 
1               5                   10                  15      


Ala Phe Ala Ser Gly Leu Val Leu Ser Arg Val Pro His Val Gln Gly 
            20                  25                  30          


Glu Gln Gln Glu Trp Glu Gly Thr Glu Glu Leu Pro Ser Pro Pro Asp 
        35                  40                  45              


His Ala Glu Arg Ala Glu Glu Gln His Glu Lys Tyr Arg Pro Ser Gln 
    50                  55                  60                  


Asp Gln Gly Leu Pro Ala Ser Arg Cys Leu Arg Cys Cys Asp Pro Gly 
65                  70                  75                  80  


Thr Ser Met Tyr Pro Ala Thr Ala Val Pro Gln Ile Asn Ile Thr Ile 
                85                  90                  95      


Leu Lys Gly Glu Lys Gly Asp Arg Gly Asp Arg Gly Leu Gln Gly Lys 
            100                 105                 110         


Tyr Gly Lys Thr Gly Ser Ala Gly Ala Arg Gly His Thr Gly Pro Lys 
        115                 120                 125             


Gly Gln Lys Gly Ser Met Gly Ala Pro Gly Glu Arg Cys Lys Ser His 
    130                 135                 140                 


Tyr Ala Ala Phe Ser Val Gly Arg Lys Lys Pro Met His Ser Asn His 
145                 150                 155                 160 


Tyr Tyr Gln Thr Val Ile Phe Asp Thr Glu Phe Val Asn Leu Tyr Asp 
                165                 170                 175     


His Phe Asn Met Phe Thr Gly Lys Phe Tyr Cys Tyr Val Pro Gly Leu 
            180                 185                 190         


Tyr Phe Phe Ser Leu Asn Val His Thr Trp Asn Gln Lys Glu Thr Tyr 
        195                 200                 205             


Leu His Ile Met Lys Asn Glu Glu Glu Val Val Ile Leu Phe Ala Gln 
    210                 215                 220                 


Val Gly Asp Arg Ser Ile Met Gln Ser Gln Ser Leu Met Leu Glu Leu 
225                 230                 235                 240 


Arg Glu Gln Asp Gln Val Trp Val Arg Leu Tyr Lys Gly Glu Arg Glu 
                245                 250                 255     


Asn Ala Ile Phe Ser Glu Glu Leu Asp Thr Tyr Ile Thr Phe Ser Gly 
            260                 265                 270         


Tyr Leu Val Lys His Ala Thr Glu Pro 
        275                 280     


<210>  1786
<211>  281
<212>  PRT
<213>  Homo Sapiens

<400>  1786

Met Gly Ser Arg Gly Gln Gly Leu Leu Leu Ala Tyr Cys Leu Leu Leu 
1               5                   10                  15      


Ala Phe Ala Ser Gly Leu Val Leu Ser Arg Val Pro His Val Gln Gly 
            20                  25                  30          


Glu Gln Gln Glu Trp Glu Gly Thr Glu Glu Leu Pro Ser Pro Pro Asp 
        35                  40                  45              


His Ala Glu Arg Ala Glu Glu Gln His Glu Lys Tyr Arg Pro Ser Gln 
    50                  55                  60                  


Asp Gln Gly Leu Pro Ala Ser Arg Cys Leu Arg Cys Cys Asp Pro Gly 
65                  70                  75                  80  


Thr Ser Met Tyr Pro Ala Thr Ala Val Pro Gln Ile Asn Ile Thr Ile 
                85                  90                  95      


Leu Lys Gly Glu Lys Gly Asp Arg Gly Asp Arg Gly Leu Gln Gly Lys 
            100                 105                 110         


Tyr Gly Lys Thr Gly Ser Ala Gly Ala Arg Gly His Thr Gly Pro Lys 
        115                 120                 125             


Gly Gln Lys Gly Ser Met Gly Ala Pro Gly Glu Arg Cys Lys Ser His 
    130                 135                 140                 


Tyr Ala Ala Phe Ser Val Gly Arg Lys Lys Pro Met His Ser Asn His 
145                 150                 155                 160 


Tyr Tyr Gln Thr Val Ile Phe Asp Thr Glu Phe Val Asn Leu Tyr Asp 
                165                 170                 175     


His Phe Asn Met Phe Thr Gly Lys Phe Tyr Cys Tyr Val Pro Gly Leu 
            180                 185                 190         


Tyr Phe Phe Ser Leu Asn Val His Thr Trp Asn Gln Lys Glu Thr Tyr 
        195                 200                 205             


Leu His Ile Met Lys Asn Glu Glu Glu Val Val Ile Leu Phe Ala Gln 
    210                 215                 220                 


Val Gly Asp Arg Ser Ile Met Gln Ser Gln Ser Leu Met Leu Glu Leu 
225                 230                 235                 240 


Arg Glu Gln Asp Gln Val Trp Val Arg Leu Tyr Lys Gly Glu Arg Glu 
                245                 250                 255     


Asn Ala Ile Phe Ser Glu Glu Leu Asp Thr Tyr Ile Thr Phe Ser Gly 
            260                 265                 270         


Tyr Leu Val Lys His Ala Thr Glu Pro 
        275                 280     


<210>  1787
<211>  281
<212>  PRT
<213>  Homo Sapiens

<400>  1787

Met Gly Ser Arg Gly Gln Gly Leu Leu Leu Ala Tyr Cys Leu Leu Leu 
1               5                   10                  15      


Ala Phe Ala Ser Gly Leu Val Leu Ser Arg Val Pro His Val Gln Gly 
            20                  25                  30          


Glu Gln Gln Glu Trp Glu Gly Thr Glu Glu Leu Pro Ser Pro Pro Asp 
        35                  40                  45              


His Ala Glu Arg Ala Glu Glu Gln His Glu Lys Tyr Arg Pro Ser Gln 
    50                  55                  60                  


Asp Gln Gly Leu Pro Ala Ser Arg Cys Leu Arg Cys Cys Asp Pro Gly 
65                  70                  75                  80  


Thr Ser Met Tyr Pro Ala Thr Ala Val Pro Gln Ile Asn Ile Thr Ile 
                85                  90                  95      


Leu Lys Gly Glu Lys Gly Asp Arg Gly Asp Arg Gly Leu Gln Gly Lys 
            100                 105                 110         


Tyr Gly Lys Thr Gly Ser Ala Gly Ala Arg Gly His Thr Gly Pro Lys 
        115                 120                 125             


Gly Gln Lys Gly Ser Met Gly Ala Pro Gly Glu Arg Cys Lys Ser His 
    130                 135                 140                 


Tyr Ala Ala Phe Ser Val Gly Arg Lys Lys Pro Met His Ser Asn His 
145                 150                 155                 160 


Tyr Tyr Gln Thr Val Ile Phe Asp Thr Glu Phe Val Asn Leu Tyr Asp 
                165                 170                 175     


His Phe Asn Met Phe Thr Gly Lys Phe Tyr Cys Tyr Val Pro Gly Leu 
            180                 185                 190         


Tyr Phe Phe Ser Leu Asn Val His Thr Trp Asn Gln Lys Glu Thr Tyr 
        195                 200                 205             


Leu His Ile Met Lys Asn Glu Glu Glu Val Val Ile Leu Phe Ala Gln 
    210                 215                 220                 


Val Gly Asp Arg Ser Ile Met Gln Ser Gln Ser Leu Met Leu Glu Leu 
225                 230                 235                 240 


Arg Glu Gln Asp Gln Val Trp Val Arg Leu Tyr Lys Gly Glu Arg Glu 
                245                 250                 255     


Asn Ala Ile Phe Ser Glu Glu Leu Asp Thr Tyr Ile Thr Phe Ser Gly 
            260                 265                 270         


Tyr Leu Val Lys His Ala Thr Glu Pro 
        275                 280     


<210>  1788
<211>  281
<212>  PRT
<213>  Homo Sapiens

<400>  1788

Met Gly Ser Arg Gly Gln Gly Leu Leu Leu Ala Tyr Cys Leu Leu Leu 
1               5                   10                  15      


Ala Phe Ala Ser Gly Leu Val Leu Ser Arg Val Pro His Val Gln Gly 
            20                  25                  30          


Glu Gln Gln Glu Trp Glu Gly Thr Glu Glu Leu Pro Ser Pro Pro Asp 
        35                  40                  45              


His Ala Glu Arg Ala Glu Glu Gln His Glu Lys Tyr Arg Pro Ser Gln 
    50                  55                  60                  


Asp Gln Gly Leu Pro Ala Ser Arg Cys Leu Arg Cys Cys Asp Pro Gly 
65                  70                  75                  80  


Thr Ser Met Tyr Pro Ala Thr Ala Val Pro Gln Ile Asn Ile Thr Ile 
                85                  90                  95      


Leu Lys Gly Glu Lys Gly Asp Arg Gly Asp Arg Gly Leu Gln Gly Lys 
            100                 105                 110         


Tyr Gly Lys Thr Gly Ser Ala Gly Ala Arg Gly His Thr Gly Pro Lys 
        115                 120                 125             


Gly Gln Lys Gly Ser Met Gly Ala Pro Gly Glu Arg Cys Lys Ser His 
    130                 135                 140                 


Tyr Ala Ala Phe Ser Val Gly Arg Lys Lys Pro Met His Ser Asn His 
145                 150                 155                 160 


Tyr Tyr Gln Thr Val Ile Phe Asp Thr Glu Phe Val Asn Leu Tyr Asp 
                165                 170                 175     


His Phe Asn Met Phe Thr Gly Lys Phe Tyr Cys Tyr Val Pro Gly Leu 
            180                 185                 190         


Tyr Phe Phe Ser Leu Asn Val His Thr Trp Asn Gln Lys Glu Thr Tyr 
        195                 200                 205             


Leu His Ile Met Lys Asn Glu Glu Glu Val Val Ile Leu Phe Ala Gln 
    210                 215                 220                 


Val Gly Asp Arg Ser Ile Met Gln Ser Gln Ser Leu Met Leu Glu Leu 
225                 230                 235                 240 


Arg Glu Gln Asp Gln Val Trp Val Arg Leu Tyr Lys Gly Glu Arg Glu 
                245                 250                 255     


Asn Ala Ile Phe Ser Glu Glu Leu Asp Thr Tyr Ile Thr Phe Ser Gly 
            260                 265                 270         


Tyr Leu Val Lys His Ala Thr Glu Pro 
        275                 280     


<210>  1789
<211>  281
<212>  PRT
<213>  Homo Sapiens

<400>  1789

Met Gly Ser Arg Gly Gln Gly Leu Leu Leu Ala Tyr Cys Leu Leu Leu 
1               5                   10                  15      


Ala Phe Ala Ser Gly Leu Val Leu Ser Arg Val Pro His Val Gln Gly 
            20                  25                  30          


Glu Gln Gln Glu Trp Glu Gly Thr Glu Glu Leu Pro Ser Pro Pro Asp 
        35                  40                  45              


His Ala Glu Arg Ala Glu Glu Gln His Glu Lys Tyr Arg Pro Ser Gln 
    50                  55                  60                  


Asp Gln Gly Leu Pro Ala Ser Arg Cys Leu Arg Cys Cys Asp Pro Gly 
65                  70                  75                  80  


Thr Ser Met Tyr Pro Ala Thr Ala Val Pro Gln Ile Asn Ile Thr Ile 
                85                  90                  95      


Leu Lys Gly Glu Lys Gly Asp Arg Gly Asp Arg Gly Leu Gln Gly Lys 
            100                 105                 110         


Tyr Gly Lys Thr Gly Ser Ala Gly Ala Arg Gly His Thr Gly Pro Lys 
        115                 120                 125             


Gly Gln Lys Gly Ser Met Gly Ala Pro Gly Glu Arg Cys Lys Ser His 
    130                 135                 140                 


Tyr Ala Ala Phe Ser Val Gly Arg Lys Lys Pro Met His Ser Asn His 
145                 150                 155                 160 


Tyr Tyr Gln Thr Val Ile Phe Asp Thr Glu Phe Val Asn Leu Tyr Asp 
                165                 170                 175     


His Phe Asn Met Phe Thr Gly Lys Phe Tyr Cys Tyr Val Pro Gly Leu 
            180                 185                 190         


Tyr Phe Phe Ser Leu Asn Val His Thr Trp Asn Gln Lys Glu Thr Tyr 
        195                 200                 205             


Leu His Ile Met Lys Asn Glu Glu Glu Val Val Ile Leu Phe Ala Gln 
    210                 215                 220                 


Val Gly Asp Arg Ser Ile Met Gln Ser Gln Ser Leu Met Leu Glu Leu 
225                 230                 235                 240 


Arg Glu Gln Asp Gln Val Trp Val Arg Leu Tyr Lys Gly Glu Arg Glu 
                245                 250                 255     


Asn Ala Ile Phe Ser Glu Glu Leu Asp Thr Tyr Ile Thr Phe Ser Gly 
            260                 265                 270         


Tyr Leu Val Lys His Ala Thr Glu Pro 
        275                 280     


<210>  1790
<211>  281
<212>  PRT
<213>  Homo Sapiens

<400>  1790

Met Gly Ser Arg Gly Gln Gly Leu Leu Leu Ala Tyr Cys Leu Leu Leu 
1               5                   10                  15      


Ala Phe Ala Ser Gly Leu Val Leu Ser Arg Val Pro His Val Gln Gly 
            20                  25                  30          


Glu Gln Gln Glu Trp Glu Gly Thr Glu Glu Leu Pro Ser Pro Pro Asp 
        35                  40                  45              


His Ala Glu Arg Ala Glu Glu Gln His Glu Lys Tyr Arg Pro Ser Gln 
    50                  55                  60                  


Asp Gln Gly Leu Pro Ala Ser Arg Cys Leu Arg Cys Cys Asp Pro Gly 
65                  70                  75                  80  


Thr Ser Met Tyr Pro Ala Thr Ala Val Pro Gln Ile Asn Ile Thr Ile 
                85                  90                  95      


Leu Lys Gly Glu Lys Gly Asp Arg Gly Asp Arg Gly Leu Gln Gly Lys 
            100                 105                 110         


Tyr Gly Lys Thr Gly Ser Ala Gly Ala Arg Gly His Thr Gly Pro Lys 
        115                 120                 125             


Gly Gln Lys Gly Ser Met Gly Ala Pro Gly Glu Arg Cys Lys Ser His 
    130                 135                 140                 


Tyr Ala Ala Phe Ser Val Gly Arg Lys Lys Pro Met His Ser Asn His 
145                 150                 155                 160 


Tyr Tyr Gln Thr Val Ile Phe Asp Thr Glu Phe Val Asn Leu Tyr Asp 
                165                 170                 175     


His Phe Asn Met Phe Thr Gly Lys Phe Tyr Cys Tyr Val Pro Gly Leu 
            180                 185                 190         


Tyr Phe Phe Ser Leu Asn Val His Thr Trp Asn Gln Lys Glu Thr Tyr 
        195                 200                 205             


Leu His Ile Met Lys Asn Glu Glu Glu Val Val Ile Leu Phe Ala Gln 
    210                 215                 220                 


Val Gly Asp Arg Ser Ile Met Gln Ser Gln Ser Leu Met Leu Glu Leu 
225                 230                 235                 240 


Arg Glu Gln Asp Gln Val Trp Val Arg Leu Tyr Lys Gly Glu Arg Glu 
                245                 250                 255     


Asn Ala Ile Phe Ser Glu Glu Leu Asp Thr Tyr Ile Thr Phe Ser Gly 
            260                 265                 270         


Tyr Leu Val Lys His Ala Thr Glu Pro 
        275                 280     


<210>  1791
<211>  281
<212>  PRT
<213>  Homo Sapiens

<400>  1791

Met Gly Ser Arg Gly Gln Gly Leu Leu Leu Ala Tyr Cys Leu Leu Leu 
1               5                   10                  15      


Ala Phe Ala Ser Gly Leu Val Leu Ser Arg Val Pro His Val Gln Gly 
            20                  25                  30          


Glu Gln Gln Glu Trp Glu Gly Thr Glu Glu Leu Pro Ser Pro Pro Asp 
        35                  40                  45              


His Ala Glu Arg Ala Glu Glu Gln His Glu Lys Tyr Arg Pro Ser Gln 
    50                  55                  60                  


Asp Gln Gly Leu Pro Ala Ser Arg Cys Leu Arg Cys Cys Asp Pro Gly 
65                  70                  75                  80  


Thr Ser Met Tyr Pro Ala Thr Ala Val Pro Gln Ile Asn Ile Thr Ile 
                85                  90                  95      


Leu Lys Gly Glu Lys Gly Asp Arg Gly Asp Arg Gly Leu Gln Gly Lys 
            100                 105                 110         


Tyr Gly Lys Thr Gly Ser Ala Gly Ala Arg Gly His Thr Gly Pro Lys 
        115                 120                 125             


Gly Gln Lys Gly Ser Met Gly Ala Pro Gly Glu Arg Cys Lys Ser His 
    130                 135                 140                 


Tyr Ala Ala Phe Ser Val Gly Arg Lys Lys Pro Met His Ser Asn His 
145                 150                 155                 160 


Tyr Tyr Gln Thr Val Ile Phe Asp Thr Glu Phe Val Asn Leu Tyr Asp 
                165                 170                 175     


His Phe Asn Met Phe Thr Gly Lys Phe Tyr Cys Tyr Val Pro Gly Leu 
            180                 185                 190         


Tyr Phe Phe Ser Leu Asn Val His Thr Trp Asn Gln Lys Glu Thr Tyr 
        195                 200                 205             


Leu His Ile Met Lys Asn Glu Glu Glu Val Val Ile Leu Phe Ala Gln 
    210                 215                 220                 


Val Gly Asp Arg Ser Ile Met Gln Ser Gln Ser Leu Met Leu Glu Leu 
225                 230                 235                 240 


Arg Glu Gln Asp Gln Val Trp Val Arg Leu Tyr Lys Gly Glu Arg Glu 
                245                 250                 255     


Asn Ala Ile Phe Ser Glu Glu Leu Asp Thr Tyr Ile Thr Phe Ser Gly 
            260                 265                 270         


Tyr Leu Val Lys His Ala Thr Glu Pro 
        275                 280     


<210>  1792
<211>  281
<212>  PRT
<213>  Homo Sapiens

<400>  1792

Met Gly Ser Arg Gly Gln Gly Leu Leu Leu Ala Tyr Cys Leu Leu Leu 
1               5                   10                  15      


Ala Phe Ala Ser Gly Leu Val Leu Ser Arg Val Pro His Val Gln Gly 
            20                  25                  30          


Glu Gln Gln Glu Trp Glu Gly Thr Glu Glu Leu Pro Ser Pro Pro Asp 
        35                  40                  45              


His Ala Glu Arg Ala Glu Glu Gln His Glu Lys Tyr Arg Pro Ser Gln 
    50                  55                  60                  


Asp Gln Gly Leu Pro Ala Ser Arg Cys Leu Arg Cys Cys Asp Pro Gly 
65                  70                  75                  80  


Thr Ser Met Tyr Pro Ala Thr Ala Val Pro Gln Ile Asn Ile Thr Ile 
                85                  90                  95      


Leu Lys Gly Glu Lys Gly Asp Arg Gly Asp Arg Gly Leu Gln Gly Lys 
            100                 105                 110         


Tyr Gly Lys Thr Gly Ser Ala Gly Ala Arg Gly His Thr Gly Pro Lys 
        115                 120                 125             


Gly Gln Lys Gly Ser Met Gly Ala Pro Gly Glu Arg Cys Lys Ser His 
    130                 135                 140                 


Tyr Ala Ala Phe Ser Val Gly Arg Lys Lys Pro Met His Ser Asn His 
145                 150                 155                 160 


Tyr Tyr Gln Thr Val Ile Phe Asp Thr Glu Phe Val Asn Leu Tyr Asp 
                165                 170                 175     


His Phe Asn Met Phe Thr Gly Lys Phe Tyr Cys Tyr Val Pro Gly Leu 
            180                 185                 190         


Tyr Phe Phe Ser Leu Asn Val His Thr Trp Asn Gln Lys Glu Thr Tyr 
        195                 200                 205             


Leu His Ile Met Lys Asn Glu Glu Glu Val Val Ile Leu Phe Ala Gln 
    210                 215                 220                 


Val Gly Asp Arg Ser Ile Met Gln Ser Gln Ser Leu Met Leu Glu Leu 
225                 230                 235                 240 


Arg Glu Gln Asp Gln Val Trp Val Arg Leu Tyr Lys Gly Glu Arg Glu 
                245                 250                 255     


Asn Ala Ile Phe Ser Glu Glu Leu Asp Thr Tyr Ile Thr Phe Ser Gly 
            260                 265                 270         


Tyr Leu Val Lys His Ala Thr Glu Pro 
        275                 280     


<210>  1793
<211>  199
<212>  PRT
<213>  Homo Sapiens

<400>  1793

Met Tyr Pro Ala Thr Ala Val Pro Gln Ile Asn Ile Thr Ile Leu Lys 
1               5                   10                  15      


Gly Glu Lys Gly Asp Arg Gly Asp Arg Gly Leu Gln Gly Lys Tyr Gly 
            20                  25                  30          


Lys Thr Gly Ser Ala Gly Ala Arg Gly His Thr Gly Pro Lys Gly Gln 
        35                  40                  45              


Lys Gly Ser Met Gly Ala Pro Gly Glu Arg Cys Lys Ser His Tyr Ala 
    50                  55                  60                  


Ala Phe Ser Val Gly Arg Lys Lys Pro Met His Ser Asn His Tyr Tyr 
65                  70                  75                  80  


Gln Thr Val Ile Phe Asp Thr Glu Phe Val Asn Leu Tyr Asp His Phe 
                85                  90                  95      


Asn Met Phe Thr Gly Lys Phe Tyr Cys Tyr Val Pro Gly Leu Tyr Phe 
            100                 105                 110         


Phe Ser Leu Asn Val His Thr Trp Asn Gln Lys Glu Thr Tyr Leu His 
        115                 120                 125             


Ile Met Lys Asn Glu Glu Glu Val Val Ile Leu Phe Ala Gln Val Gly 
    130                 135                 140                 


Asp Arg Ser Ile Met Gln Ser Gln Ser Leu Met Leu Glu Leu Arg Glu 
145                 150                 155                 160 


Gln Asp Gln Val Trp Val Arg Leu Tyr Lys Gly Glu Arg Glu Asn Ala 
                165                 170                 175     


Ile Phe Ser Glu Glu Leu Asp Thr Tyr Ile Thr Phe Ser Gly Tyr Leu 
            180                 185                 190         


Val Lys His Ala Thr Glu Pro 
        195                 


<210>  1794
<211>  199
<212>  PRT
<213>  Homo Sapiens

<400>  1794

Met Tyr Pro Ala Thr Ala Val Pro Gln Ile Asn Ile Thr Ile Leu Lys 
1               5                   10                  15      


Gly Glu Lys Gly Asp Arg Gly Asp Arg Gly Leu Gln Gly Lys Tyr Gly 
            20                  25                  30          


Lys Thr Gly Ser Ala Gly Ala Arg Gly His Thr Gly Pro Lys Gly Gln 
        35                  40                  45              


Lys Gly Ser Met Gly Ala Pro Gly Glu Arg Cys Lys Ser His Tyr Ala 
    50                  55                  60                  


Ala Phe Ser Val Gly Arg Lys Lys Pro Met His Ser Asn His Tyr Tyr 
65                  70                  75                  80  


Gln Thr Val Ile Phe Asp Thr Glu Phe Val Asn Leu Tyr Asp His Phe 
                85                  90                  95      


Asn Met Phe Thr Gly Lys Phe Tyr Cys Tyr Val Pro Gly Leu Tyr Phe 
            100                 105                 110         


Phe Ser Leu Asn Val His Thr Trp Asn Gln Lys Glu Thr Tyr Leu His 
        115                 120                 125             


Ile Met Lys Asn Glu Glu Glu Val Val Ile Leu Phe Ala Gln Val Gly 
    130                 135                 140                 


Asp Arg Ser Ile Met Gln Ser Gln Ser Leu Met Leu Glu Leu Arg Glu 
145                 150                 155                 160 


Gln Asp Gln Val Trp Val Arg Leu Tyr Lys Gly Glu Arg Glu Asn Ala 
                165                 170                 175     


Ile Phe Ser Glu Glu Leu Asp Thr Tyr Ile Thr Phe Ser Gly Tyr Leu 
            180                 185                 190         


Val Lys His Ala Thr Glu Pro 
        195                 


<210>  1795
<211>  302
<212>  PRT
<213>  Homo Sapiens

<400>  1795

Met Arg Arg Trp Ala Trp Ala Ala Val Val Val Leu Leu Gly Pro Gln 
1               5                   10                  15      


Leu Val Leu Leu Gly Gly Val Gly Ala Arg Arg Glu Ala Gln Arg Thr 
            20                  25                  30          


Gln Gln Pro Gly Gln Arg Ala Asp Pro Pro Asn Ala Thr Ala Ser Ala 
        35                  40                  45              


Ser Ser Arg Glu Gly Leu Pro Glu Ala Pro Lys Pro Ser Gln Ala Ser 
    50                  55                  60                  


Gly Pro Glu Phe Ser Asp Ala His Met Thr Trp Leu Asn Phe Val Arg 
65                  70                  75                  80  


Arg Pro Asp Asp Gly Ala Leu Arg Lys Arg Cys Gly Ser Arg Asp Lys 
                85                  90                  95      


Lys Pro Arg Asp Leu Phe Gly Pro Pro Gly Pro Pro Gly Ala Glu Val 
            100                 105                 110         


Thr Ala Glu Thr Leu Leu His Glu Phe Gln Glu Leu Leu Lys Glu Ala 
        115                 120                 125             


Thr Glu Arg Arg Phe Ser Gly Leu Leu Asp Pro Leu Leu Pro Gln Gly 
    130                 135                 140                 


Ala Gly Leu Arg Leu Val Gly Glu Ala Phe His Cys Arg Leu Gln Gly 
145                 150                 155                 160 


Pro Arg Arg Val Asp Lys Arg Thr Leu Val Glu Leu His Gly Phe Gln 
                165                 170                 175     


Ala Pro Ala Ala Gln Gly Ala Phe Leu Arg Gly Ser Gly Leu Ser Leu 
            180                 185                 190         


Ala Ser Gly Arg Phe Thr Ala Pro Val Ser Gly Ile Phe Gln Phe Ser 
        195                 200                 205             


Ala Ser Leu His Val Asp His Ser Glu Leu Gln Gly Lys Ala Arg Leu 
    210                 215                 220                 


Arg Ala Arg Asp Val Val Cys Val Leu Ile Cys Ile Glu Ser Leu Cys 
225                 230                 235                 240 


Gln Arg His Thr Cys Leu Glu Ala Val Ser Gly Leu Glu Ser Asn Ser 
                245                 250                 255     


Arg Val Phe Thr Leu Gln Val Gln Gly Leu Leu Gln Leu Gln Ala Gly 
            260                 265                 270         


Gln Tyr Ala Ser Val Phe Val Asp Asn Gly Ser Gly Ala Val Leu Thr 
        275                 280                 285             


Ile Gln Ala Gly Ser Ser Phe Ser Gly Leu Leu Leu Gly Thr 
    290                 295                 300         


<210>  1796
<211>  330
<212>  PRT
<213>  Homo Sapiens

<400>  1796

Met Gly Lys Leu Cys Leu Gly Pro Thr Leu Cys Pro Ala Ala Ala Ala 
1               5                   10                  15      


Glu Glu Ser Arg Asp Ala Glu Pro Arg Arg Glu Leu Leu Cys Ser Gly 
            20                  25                  30          


Arg Pro Trp Thr Trp Arg Ala Ala Ala Arg Val Thr Thr Met Ile Pro 
        35                  40                  45              


Trp Val Leu Leu Ala Cys Ala Leu Pro Cys Ala Ala Asp Pro Leu Leu 
    50                  55                  60                  


Gly Ala Phe Ala Arg Arg Asp Phe Arg Lys Gly Ser Pro Gln Leu Val 
65                  70                  75                  80  


Cys Ser Leu Pro Gly Pro Gln Gly Pro Pro Gly Pro Pro Gly Ala Pro 
                85                  90                  95      


Gly Pro Ser Gly Met Met Gly Arg Met Gly Phe Pro Gly Lys Asp Gly 
            100                 105                 110         


Gln Asp Gly His Asp Gly Asp Arg Gly Asp Ser Gly Glu Glu Gly Pro 
        115                 120                 125             


Pro Gly Arg Thr Gly Asn Arg Gly Lys Pro Gly Pro Lys Gly Lys Ala 
    130                 135                 140                 


Gly Ala Ile Gly Arg Ala Gly Pro Arg Gly Pro Lys Gly Val Asn Gly 
145                 150                 155                 160 


Thr Pro Gly Lys His Gly Thr Pro Gly Lys Lys Gly Pro Lys Gly Lys 
                165                 170                 175     


Lys Gly Glu Pro Gly Leu Pro Gly Pro Cys Ser Cys Gly Ser Gly His 
            180                 185                 190         


Thr Lys Ser Ala Phe Ser Val Ala Val Thr Lys Ser Tyr Pro Arg Glu 
        195                 200                 205             


Arg Leu Pro Ile Lys Phe Asp Lys Ile Leu Met Asn Glu Gly Gly His 
    210                 215                 220                 


Tyr Asn Ala Ser Ser Gly Lys Phe Val Cys Gly Val Pro Gly Ile Tyr 
225                 230                 235                 240 


Tyr Phe Thr Tyr Asp Ile Thr Leu Ala Asn Lys His Leu Ala Ile Gly 
                245                 250                 255     


Leu Val His Asn Gly Gln Tyr Arg Ile Arg Thr Phe Asp Ala Asn Thr 
            260                 265                 270         


Gly Asn His Asp Val Ala Ser Gly Ser Thr Ile Leu Ala Leu Lys Gln 
        275                 280                 285             


Gly Asp Glu Val Trp Leu Gln Ile Phe Tyr Ser Glu Gln Asn Gly Leu 
    290                 295                 300                 


Phe Tyr Asp Pro Tyr Trp Thr Asp Ser Leu Phe Thr Gly Phe Leu Ile 
305                 310                 315                 320 


Tyr Ala Asp Gln Asp Asp Pro Asn Glu Val 
                325                 330 


<210>  1797
<211>  246
<212>  PRT
<213>  Homo Sapiens

<400>  1797

Met Leu Trp Arg Gln Leu Ile Tyr Trp Gln Leu Leu Ala Leu Phe Phe 
1               5                   10                  15      


Leu Pro Phe Cys Leu Cys Gln Asp Glu Tyr Met Glu Ser Pro Gln Thr 
            20                  25                  30          


Gly Gly Leu Pro Pro Asp Cys Ser Lys Cys Cys His Gly Asp Tyr Ser 
        35                  40                  45              


Phe Arg Gly Tyr Gln Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Ile 
    50                  55                  60                  


Pro Gly Asn His Gly Asn Asn Gly Asn Asn Gly Ala Thr Gly His Glu 
65                  70                  75                  80  


Gly Ala Lys Gly Glu Lys Gly Asp Lys Gly Asp Leu Gly Pro Arg Gly 
                85                  90                  95      


Glu Arg Gly Gln His Gly Pro Lys Gly Glu Lys Gly Tyr Pro Gly Ile 
            100                 105                 110         


Pro Pro Glu Leu Gln Ile Ala Phe Met Ala Ser Leu Ala Thr His Phe 
        115                 120                 125             


Ser Asn Gln Asn Ser Gly Ile Ile Phe Ser Ser Val Glu Thr Asn Ile 
    130                 135                 140                 


Gly Asn Phe Phe Asp Val Met Thr Gly Arg Phe Gly Ala Pro Val Ser 
145                 150                 155                 160 


Gly Val Tyr Phe Phe Thr Phe Ser Met Met Lys His Glu Asp Val Glu 
                165                 170                 175     


Glu Val Tyr Val Tyr Leu Met His Asn Gly Asn Thr Val Phe Ser Met 
            180                 185                 190         


Tyr Ser Tyr Glu Met Lys Gly Lys Ser Asp Thr Ser Ser Asn His Ala 
        195                 200                 205             


Val Leu Lys Leu Ala Lys Gly Asp Glu Val Trp Leu Arg Met Gly Asn 
    210                 215                 220                 


Gly Ala Leu His Gly Asp His Gln Arg Phe Ser Thr Phe Ala Gly Phe 
225                 230                 235                 240 


Leu Leu Phe Glu Thr Lys 
                245     


<210>  1798
<211>  319
<212>  PRT
<213>  Homo Sapiens

<400>  1798

Met Leu Trp Arg Gln Leu Ile Tyr Trp Gln Leu Leu Ala Leu Phe Phe 
1               5                   10                  15      


Leu Pro Phe Cys Leu Cys Gln Asp Glu Tyr Met Glu Val Ser Gly Arg 
            20                  25                  30          


Thr Asn Lys Val Val Ala Arg Ile Val Gln Ser His Gln Gln Thr Gly 
        35                  40                  45              


Arg Ser Gly Ser Arg Arg Glu Lys Val Arg Glu Arg Ser His Pro Lys 
    50                  55                  60                  


Thr Gly Thr Val Asp Asn Asn Thr Ser Thr Asp Leu Lys Ser Leu Arg 
65                  70                  75                  80  


Pro Asp Glu Leu Pro His Pro Glu Val Asp Asp Leu Ala Gln Ile Thr 
                85                  90                  95      


Thr Phe Trp Gly Gln Ser Pro Gln Thr Gly Gly Leu Pro Pro Asp Cys 
            100                 105                 110         


Ser Lys Cys Cys His Gly Asp Tyr Ser Phe Arg Gly Tyr Gln Gly Pro 
        115                 120                 125             


Pro Gly Pro Pro Gly Pro Pro Gly Ile Pro Gly Asn His Gly Asn Asn 
    130                 135                 140                 


Gly Asn Asn Gly Ala Thr Gly His Glu Gly Ala Lys Gly Glu Lys Gly 
145                 150                 155                 160 


Asp Lys Gly Asp Leu Gly Pro Arg Gly Glu Arg Gly Gln His Gly Pro 
                165                 170                 175     


Lys Gly Glu Lys Gly Tyr Pro Gly Ile Pro Pro Glu Leu Gln Ile Ala 
            180                 185                 190         


Phe Met Ala Ser Leu Ala Thr His Phe Ser Asn Gln Asn Ser Gly Ile 
        195                 200                 205             


Ile Phe Ser Ser Val Glu Thr Asn Ile Gly Asn Phe Phe Asp Val Met 
    210                 215                 220                 


Thr Gly Arg Phe Gly Ala Pro Val Ser Gly Val Tyr Phe Phe Thr Phe 
225                 230                 235                 240 


Ser Met Met Lys His Glu Asp Val Glu Glu Val Tyr Val Tyr Leu Met 
                245                 250                 255     


His Asn Gly Asn Thr Val Phe Ser Met Tyr Ser Tyr Glu Met Lys Gly 
            260                 265                 270         


Lys Ser Asp Thr Ser Ser Asn His Ala Val Leu Lys Leu Ala Lys Gly 
        275                 280                 285             


Asp Glu Val Trp Leu Arg Met Gly Asn Gly Ala Leu His Gly Asp His 
    290                 295                 300                 


Gln Arg Phe Ser Thr Phe Ala Gly Phe Leu Leu Phe Glu Thr Lys 
305                 310                 315                 


<210>  1799
<211>  100
<212>  PRT
<213>  Homo Sapiens

<400>  1799

Met Leu Pro Leu Leu Leu Gly Leu Leu Gly Pro Ala Ala Cys Trp Ala 
1               5                   10                  15      


Leu Gly Pro Thr Pro Gly Pro Gly Ser Ser Glu Leu Arg Ser Ala Phe 
            20                  25                  30          


Ser Ala Ala Arg Thr Thr Pro Leu Glu Gly Thr Ser Glu Met Ala Val 
        35                  40                  45              


Thr Phe Asp Lys Val Tyr Val Asn Ile Gly Gly Asp Phe Asp Val Ala 
    50                  55                  60                  


Thr Gly Gln Phe Arg Cys Arg Val Pro Gly Ala Tyr Phe Phe Ser Phe 
65                  70                  75                  80  


Thr Ala Gly Lys Ala Pro His Lys Ser Leu Ser Val Met Leu Val Arg 
                85                  90                  95      


Asn Arg Asp Glu 
            100 


<210>  1800
<211>  329
<212>  PRT
<213>  Homo Sapiens

<400>  1800

Met Leu Pro Leu Leu Leu Gly Leu Leu Gly Pro Ala Ala Cys Trp Ala 
1               5                   10                  15      


Leu Gly Pro Thr Pro Gly Pro Gly Ser Ser Glu Leu Arg Ser Ala Phe 
            20                  25                  30          


Ser Ala Ala Arg Thr Thr Pro Leu Glu Gly Thr Ser Glu Met Ala Val 
        35                  40                  45              


Thr Phe Asp Lys Val Tyr Val Asn Ile Gly Gly Asp Phe Asp Val Ala 
    50                  55                  60                  


Thr Gly Gln Phe Arg Cys Arg Val Pro Gly Ala Tyr Phe Phe Ser Phe 
65                  70                  75                  80  


Thr Ala Gly Lys Ala Pro His Lys Ser Leu Ser Val Met Leu Val Arg 
                85                  90                  95      


Asn Arg Asp Glu Val Gln Ala Leu Ala Phe Asp Glu Gln Arg Arg Pro 
            100                 105                 110         


Gly Ala Arg Arg Ala Ala Ser Gln Ser Ala Met Leu Gln Leu Asp Tyr 
        115                 120                 125             


Gly Asp Thr Val Trp Leu Arg Leu His Gly Ala Pro Gln Tyr Ala Leu 
    130                 135                 140                 


Gly Ala Pro Gly Ala Thr Phe Ser Gly Tyr Leu Val Tyr Ala Asp Ala 
145                 150                 155                 160 


Asp Ala Asp Ala Pro Ala Arg Gly Pro Pro Ala Pro Pro Glu Pro Arg 
                165                 170                 175     


Ser Ala Phe Ser Ala Ala Arg Thr Arg Ser Leu Val Gly Ser Asp Ala 
            180                 185                 190         


Gly Pro Gly Pro Arg His Gln Pro Leu Ala Phe Asp Thr Glu Phe Val 
        195                 200                 205             


Asn Ile Gly Gly Asp Phe Asp Ala Ala Ala Gly Val Phe Arg Cys Arg 
    210                 215                 220                 


Leu Pro Gly Ala Tyr Phe Phe Ser Phe Thr Leu Gly Lys Leu Pro Arg 
225                 230                 235                 240 


Lys Thr Leu Ser Val Lys Leu Met Lys Asn Arg Asp Glu Val Gln Ala 
                245                 250                 255     


Met Ile Tyr Asp Asp Gly Ala Ser Arg Arg Arg Glu Met Gln Ser Gln 
            260                 265                 270         


Ser Val Met Leu Ala Leu Arg Arg Gly Asp Ala Val Trp Leu Leu Ser 
        275                 280                 285             


His Asp His Asp Gly Tyr Gly Ala Tyr Ser Asn His Gly Lys Tyr Ile 
    290                 295                 300                 


Thr Phe Ser Gly Phe Leu Val Tyr Pro Asp Leu Ala Pro Ala Ala Pro 
305                 310                 315                 320 


Pro Gly Leu Gly Ala Ser Glu Leu Leu 
                325                 


<210>  1801
<211>  60
<212>  PRT
<213>  Homo Sapiens

<400>  1801

Met Arg Pro Leu Leu Val Leu Leu Leu Leu Gly Leu Ala Ala Gly Ser 
1               5                   10                  15      


Pro Pro Leu Asp Asp Asn Lys Ile Pro Ser Leu Cys Pro Gly His Pro 
            20                  25                  30          


Gly Leu Pro Gly Leu Pro Gly Pro Arg Gly Asp Pro Gly Pro Arg Gly 
        35                  40                  45              


Glu Ala Gly Pro Ala Gly Pro Thr Gly Pro Ala Gly 
    50                  55                  60  


<210>  1802
<211>  243
<212>  PRT
<213>  Homo Sapiens

<400>  1802

Met Arg Pro Leu Leu Val Leu Leu Leu Leu Gly Leu Ala Ala Gly Ser 
1               5                   10                  15      


Pro Pro Leu Asp Asp Asn Lys Ile Pro Ser Leu Cys Pro Gly His Pro 
            20                  25                  30          


Gly Leu Pro Gly Thr Pro Gly His His Gly Ser Gln Gly Leu Pro Gly 
        35                  40                  45              


Arg Asp Gly Arg Asp Gly Arg Asp Gly Ala Pro Gly Ala Pro Gly Glu 
    50                  55                  60                  


Lys Gly Glu Gly Gly Arg Pro Gly Leu Pro Gly Pro Arg Gly Asp Pro 
65                  70                  75                  80  


Gly Pro Arg Gly Glu Ala Gly Pro Ala Gly Pro Thr Gly Pro Ala Gly 
                85                  90                  95      


Glu Cys Ser Val Pro Pro Arg Ser Ala Phe Ser Ala Lys Arg Ser Glu 
            100                 105                 110         


Ser Arg Val Pro Pro Pro Ser Asp Ala Pro Leu Pro Phe Asp Arg Val 
        115                 120                 125             


Leu Val Asn Glu Gln Gly His Tyr Asp Ala Val Thr Gly Lys Phe Thr 
    130                 135                 140                 


Cys Gln Val Pro Gly Val Tyr Tyr Phe Ala Val His Ala Thr Val Tyr 
145                 150                 155                 160 


Arg Ala Ser Leu Gln Phe Asp Leu Val Lys Asn Gly Glu Ser Ile Ala 
                165                 170                 175     


Ser Phe Phe Gln Phe Phe Gly Gly Trp Pro Lys Pro Ala Ser Leu Ser 
            180                 185                 190         


Gly Gly Ala Met Val Arg Leu Glu Pro Glu Asp Gln Val Trp Val Gln 
        195                 200                 205             


Val Gly Val Gly Asp Tyr Ile Gly Ile Tyr Ala Ser Ile Lys Thr Asp 
    210                 215                 220                 


Ser Thr Phe Ser Gly Phe Leu Val Tyr Ser Asp Trp His Ser Ser Pro 
225                 230                 235                 240 


Val Phe Ala 
            


<210>  1803
<211>  243
<212>  PRT
<213>  Homo Sapiens

<400>  1803

Met Arg Pro Leu Leu Val Leu Leu Leu Leu Gly Leu Ala Ala Gly Ser 
1               5                   10                  15      


Pro Pro Leu Asp Asp Asn Lys Ile Pro Ser Leu Cys Pro Gly His Pro 
            20                  25                  30          


Gly Leu Pro Gly Thr Pro Gly His His Gly Ser Gln Gly Leu Pro Gly 
        35                  40                  45              


Arg Asp Gly Arg Asp Gly Arg Asp Gly Ala Pro Gly Ala Pro Gly Glu 
    50                  55                  60                  


Lys Gly Glu Gly Gly Arg Pro Gly Leu Pro Gly Pro Arg Gly Asp Pro 
65                  70                  75                  80  


Gly Pro Arg Gly Glu Ala Gly Pro Ala Gly Pro Thr Gly Pro Ala Gly 
                85                  90                  95      


Glu Cys Ser Val Pro Pro Arg Ser Ala Phe Ser Ala Lys Arg Ser Glu 
            100                 105                 110         


Ser Arg Val Pro Pro Pro Ser Asp Ala Pro Leu Pro Phe Asp Arg Val 
        115                 120                 125             


Leu Val Asn Glu Gln Gly His Tyr Asp Ala Val Thr Gly Lys Phe Thr 
    130                 135                 140                 


Cys Gln Val Pro Gly Val Tyr Tyr Phe Ala Val His Ala Thr Val Tyr 
145                 150                 155                 160 


Arg Ala Ser Leu Gln Phe Asp Leu Val Lys Asn Gly Glu Ser Ile Ala 
                165                 170                 175     


Ser Phe Phe Gln Phe Phe Gly Gly Trp Pro Lys Pro Ala Ser Leu Ser 
            180                 185                 190         


Gly Gly Ala Met Val Arg Leu Glu Pro Glu Asp Gln Val Trp Val Gln 
        195                 200                 205             


Val Gly Val Gly Asp Tyr Ile Gly Ile Tyr Ala Ser Ile Lys Thr Asp 
    210                 215                 220                 


Ser Thr Phe Ser Gly Phe Leu Val Tyr Ser Asp Trp His Ser Ser Pro 
225                 230                 235                 240 


Val Phe Ala 
            


<210>  1804
<211>  112
<212>  PRT
<213>  Homo Sapiens

<400>  1804

Met Phe Val Leu Leu Tyr Val Thr Ser Phe Ala Ile Cys Ala Ser Gly 
1               5                   10                  15      


Gln Pro Arg Gly Asn Gln Leu Lys Gly Glu Asn Tyr Ser Pro Arg Tyr 
            20                  25                  30          


Ile Cys Ser Ile Pro Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Ala 
        35                  40                  45              


Asn Gly Ser Pro Gly Pro His Gly Arg Ile Gly Leu Pro Gly Arg Asp 
    50                  55                  60                  


Gly Arg Asp Gly Arg Lys Gly Glu Lys Gly Glu Lys Gly Thr Ala Gly 
65                  70                  75                  80  


Leu Arg Gly Lys Thr Gly Pro Leu Gly Leu Ala Gly Glu Lys Gly Asp 
                85                  90                  95      


Gln Gly Glu Thr Gly Lys Lys Gly Pro Ile Gly Pro Glu Gly Glu Lys 
            100                 105                 110         


<210>  1805
<211>  289
<212>  PRT
<213>  Homo Sapiens

<400>  1805

Met Phe Val Leu Leu Tyr Val Thr Ser Phe Ala Ile Cys Ala Ser Gly 
1               5                   10                  15      


Gln Pro Arg Gly Asn Gln Leu Lys Gly Glu Asn Tyr Ser Pro Arg Tyr 
            20                  25                  30          


Ile Cys Ser Ile Pro Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Ala 
        35                  40                  45              


Asn Gly Ser Pro Gly Pro His Gly Arg Ile Gly Leu Pro Gly Arg Asp 
    50                  55                  60                  


Gly Arg Asp Gly Arg Lys Gly Glu Lys Gly Glu Lys Gly Thr Ala Gly 
65                  70                  75                  80  


Leu Arg Gly Lys Thr Gly Pro Leu Gly Leu Ala Gly Glu Lys Gly Asp 
                85                  90                  95      


Gln Gly Glu Thr Gly Lys Lys Gly Pro Ile Gly Pro Glu Gly Glu Lys 
            100                 105                 110         


Gly Glu Val Gly Pro Ile Gly Pro Pro Gly Pro Lys Gly Asp Arg Gly 
        115                 120                 125             


Glu Gln Gly Asp Pro Gly Leu Pro Gly Val Cys Arg Cys Gly Ser Ile 
    130                 135                 140                 


Val Leu Lys Ser Ala Phe Ser Val Gly Ile Thr Thr Ser Tyr Pro Glu 
145                 150                 155                 160 


Glu Arg Leu Pro Ile Ile Phe Asn Lys Val Leu Phe Asn Glu Gly Glu 
                165                 170                 175     


His Tyr Asn Pro Ala Thr Gly Lys Phe Ile Cys Ala Phe Pro Gly Ile 
            180                 185                 190         


Tyr Tyr Phe Ser Tyr Asp Ile Thr Leu Ala Asn Lys His Leu Ala Ile 
        195                 200                 205             


Gly Leu Val His Asn Gly Gln Tyr Arg Ile Lys Thr Phe Asp Ala Asn 
    210                 215                 220                 


Thr Gly Asn His Asp Val Ala Ser Gly Ser Thr Val Ile Tyr Leu Gln 
225                 230                 235                 240 


Pro Glu Asp Glu Val Trp Leu Glu Ile Phe Phe Thr Asp Gln Asn Gly 
                245                 250                 255     


Leu Phe Ser Asp Pro Gly Trp Ala Asp Ser Leu Phe Ser Gly Phe Leu 
            260                 265                 270         


Leu Tyr Val Asp Thr Asp Tyr Leu Asp Ser Ile Ser Glu Asp Asp Glu 
        275                 280                 285             


Leu 
    


<210>  1806
<211>  289
<212>  PRT
<213>  Homo Sapiens

<400>  1806

Met Phe Val Leu Leu Tyr Val Thr Ser Phe Ala Ile Cys Ala Ser Gly 
1               5                   10                  15      


Gln Pro Arg Gly Asn Gln Leu Lys Gly Glu Asn Tyr Ser Pro Arg Tyr 
            20                  25                  30          


Ile Cys Ser Ile Pro Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Ala 
        35                  40                  45              


Asn Gly Ser Pro Gly Pro His Gly Arg Ile Gly Leu Pro Gly Arg Asp 
    50                  55                  60                  


Gly Arg Asp Gly Arg Lys Gly Glu Lys Gly Glu Lys Gly Thr Ala Gly 
65                  70                  75                  80  


Leu Arg Gly Lys Thr Gly Pro Leu Gly Leu Ala Gly Glu Lys Gly Asp 
                85                  90                  95      


Gln Gly Glu Thr Gly Lys Lys Gly Pro Ile Gly Pro Glu Gly Glu Lys 
            100                 105                 110         


Gly Glu Val Gly Pro Ile Gly Pro Pro Gly Pro Lys Gly Asp Arg Gly 
        115                 120                 125             


Glu Gln Gly Asp Pro Gly Leu Pro Gly Val Cys Arg Cys Gly Ser Ile 
    130                 135                 140                 


Val Leu Lys Ser Ala Phe Ser Val Gly Ile Thr Thr Ser Tyr Pro Glu 
145                 150                 155                 160 


Glu Arg Leu Pro Ile Ile Phe Asn Lys Val Leu Phe Asn Glu Gly Glu 
                165                 170                 175     


His Tyr Asn Pro Ala Thr Gly Lys Phe Ile Cys Ala Phe Pro Gly Ile 
            180                 185                 190         


Tyr Tyr Phe Ser Tyr Asp Ile Thr Leu Ala Asn Lys His Leu Ala Ile 
        195                 200                 205             


Gly Leu Val His Asn Gly Gln Tyr Arg Ile Lys Thr Phe Asp Ala Asn 
    210                 215                 220                 


Thr Gly Asn His Asp Val Ala Ser Gly Ser Thr Val Ile Tyr Leu Gln 
225                 230                 235                 240 


Pro Glu Asp Glu Val Trp Leu Glu Ile Phe Phe Thr Asp Gln Asn Gly 
                245                 250                 255     


Leu Phe Ser Asp Pro Gly Trp Ala Asp Ser Leu Phe Ser Gly Phe Leu 
            260                 265                 270         


Leu Tyr Val Asp Thr Asp Tyr Leu Asp Ser Ile Ser Glu Asp Asp Glu 
        275                 280                 285             


Leu 
    


<210>  1807
<211>  151
<212>  PRT
<213>  Homo Sapiens

<400>  1807

Met Ser Arg Gln Glu Pro Lys Met Phe Val Leu Leu Tyr Val Thr Ser 
1               5                   10                  15      


Phe Ala Ile Cys Ala Ser Gly Gln Pro Arg Gly Asn Gln Leu Lys Gly 
            20                  25                  30          


Glu Asn Tyr Ser Pro Arg Tyr Ile Cys Ser Ile Pro Gly Leu Pro Gly 
        35                  40                  45              


Pro Pro Gly Pro Pro Gly Ala Asn Gly Ser Pro Gly Pro His Gly Arg 
    50                  55                  60                  


Ile Gly Leu Pro Gly Arg Asp Gly Arg Asp Gly Arg Lys Gly Glu Lys 
65                  70                  75                  80  


Gly Glu Lys Gly Thr Ala Gly Leu Arg Gly Lys Thr Gly Pro Leu Gly 
                85                  90                  95      


Leu Ala Gly Glu Lys Gly Asp Gln Gly Glu Thr Gly Lys Lys Gly Pro 
            100                 105                 110         


Ile Gly Pro Glu Gly Glu Lys Gly Glu Val Gly Pro Ile Gly Pro Pro 
        115                 120                 125             


Gly Pro Lys Gly Asp Arg Gly Glu Gln Gly Asp Pro Gly Leu Pro Gly 
    130                 135                 140                 


Val Cys Arg Cys Gly Ser Ile 
145                 150     


<210>  1808
<211>  296
<212>  PRT
<213>  Homo Sapiens

<400>  1808

Met Ser Arg Gln Glu Pro Lys Met Phe Val Leu Leu Tyr Val Thr Ser 
1               5                   10                  15      


Phe Ala Ile Cys Ala Ser Gly Gln Pro Arg Gly Asn Gln Leu Lys Gly 
            20                  25                  30          


Glu Asn Tyr Ser Pro Arg Tyr Ile Cys Ser Ile Pro Gly Leu Pro Gly 
        35                  40                  45              


Pro Pro Gly Pro Pro Gly Ala Asn Gly Ser Pro Gly Pro His Gly Arg 
    50                  55                  60                  


Ile Gly Leu Pro Gly Arg Asp Gly Arg Asp Gly Arg Lys Gly Glu Lys 
65                  70                  75                  80  


Gly Glu Lys Gly Thr Ala Gly Leu Arg Gly Lys Thr Gly Pro Leu Gly 
                85                  90                  95      


Leu Ala Gly Glu Lys Gly Asp Gln Gly Glu Thr Gly Lys Lys Gly Pro 
            100                 105                 110         


Ile Gly Pro Glu Gly Glu Lys Gly Glu Val Gly Pro Ile Gly Pro Pro 
        115                 120                 125             


Gly Pro Lys Gly Asp Arg Gly Glu Gln Gly Asp Pro Gly Leu Pro Gly 
    130                 135                 140                 


Val Cys Arg Cys Gly Ser Ile Val Leu Lys Ser Ala Phe Ser Val Gly 
145                 150                 155                 160 


Ile Thr Thr Ser Tyr Pro Glu Glu Arg Leu Pro Ile Ile Phe Asn Lys 
                165                 170                 175     


Val Leu Phe Asn Glu Gly Glu His Tyr Asn Pro Ala Thr Gly Lys Phe 
            180                 185                 190         


Ile Cys Ala Phe Pro Gly Ile Tyr Tyr Phe Ser Tyr Asp Ile Thr Leu 
        195                 200                 205             


Ala Asn Lys His Leu Ala Ile Gly Leu Val His Asn Gly Gln Tyr Arg 
    210                 215                 220                 


Ile Lys Thr Phe Asp Ala Asn Thr Gly Asn His Asp Val Ala Ser Gly 
225                 230                 235                 240 


Ser Thr Val Ile Tyr Leu Gln Pro Glu Asp Glu Val Trp Leu Glu Ile 
                245                 250                 255     


Phe Phe Thr Asp Gln Asn Gly Leu Phe Ser Asp Pro Gly Trp Ala Asp 
            260                 265                 270         


Ser Leu Phe Ser Gly Phe Leu Leu Tyr Val Asp Thr Asp Tyr Leu Asp 
        275                 280                 285             


Ser Ile Ser Glu Asp Asp Glu Leu 
    290                 295     


<210>  1809
<211>  256
<212>  PRT
<213>  Homo Sapiens

<400>  1809

Met Ala Ala Pro Ala Leu Leu Leu Leu Ala Leu Leu Leu Pro Val Gly 
1               5                   10                  15      


Ala Trp Pro Gly Leu Pro Arg Arg Pro Cys Val His Cys Cys Arg Pro 
            20                  25                  30          


Ala Trp Pro Pro Gly Pro Tyr Ala Arg Val Ser Asp Arg Asp Leu Trp 
        35                  40                  45              


Arg Gly Asp Leu Trp Arg Gly Leu Pro Arg Val Arg Pro Thr Ile Asp 
    50                  55                  60                  


Ile Glu Ile Leu Lys Gly Glu Ala Arg Gly Cys Ala Cys Met Leu Pro 
65                  70                  75                  80  


His Gln Asp Pro Thr Ala Gln Gly Val Gly Ser Thr Trp Gly Glu Glu 
                85                  90                  95      


Gly Arg Glu Gly Thr Leu Ser Thr Ser Val Cys Pro Gly Ser Ala Pro 
            100                 105                 110         


Cys Thr Ala Cys Arg Arg Ala Tyr Ala Ala Phe Ser Val Gly Arg Arg 
        115                 120                 125             


Glu Gly Leu His Ser Ser Asp His Phe Gln Ala Val Pro Phe Asp Thr 
    130                 135                 140                 


Glu Leu Val Asn Leu Asp Gly Ala Phe Asp Leu Ala Ala Gly Arg Phe 
145                 150                 155                 160 


Leu Cys Thr Val Pro Gly Val Tyr Phe Leu Ser Leu Asn Val His Thr 
                165                 170                 175     


Trp Asn Tyr Lys Glu Thr Tyr Leu His Ile Met Leu Asn Arg Arg Pro 
            180                 185                 190         


Ala Ala Val Leu Tyr Ala Gln Pro Ser Glu Arg Ser Val Met Gln Ala 
        195                 200                 205             


Gln Ser Leu Met Leu Leu Leu Ala Ala Gly Asp Ala Val Trp Val Arg 
    210                 215                 220                 


Met Phe Gln Arg Asp Arg Asp Asn Ala Ile Tyr Gly Glu His Gly Asp 
225                 230                 235                 240 


Leu Tyr Ile Thr Phe Ser Gly His Leu Val Lys Pro Ala Ala Glu Leu 
                245                 250                 255     


<210>  1810
<211>  252
<212>  PRT
<213>  Homo Sapiens

<400>  1810

Met Ala Ala Pro Ala Leu Leu Leu Leu Ala Leu Leu Leu Pro Val Gly 
1               5                   10                  15      


Ala Trp Pro Gly Leu Pro Arg Arg Pro Cys Val His Cys Cys Arg Pro 
            20                  25                  30          


Ala Trp Pro Pro Gly Pro Tyr Ala Arg Val Ser Asp Arg Asp Leu Trp 
        35                  40                  45              


Arg Gly Asp Leu Trp Arg Gly Leu Pro Arg Val Arg Pro Thr Ile Asp 
    50                  55                  60                  


Ile Glu Ile Leu Lys Gly Glu Lys Gly Glu Ala Gly Val Arg Gly Arg 
65                  70                  75                  80  


Ala Gly Arg Ser Gly Lys Glu Gly Pro Pro Gly Ala Arg Gly Leu Gln 
                85                  90                  95      


Gly Arg Arg Gly Gln Lys Gly Gln Val Gly Pro Pro Gly Ala Ala Cys 
            100                 105                 110         


Arg Arg Ala Tyr Ala Ala Phe Ser Val Gly Arg Arg Glu Gly Leu His 
        115                 120                 125             


Ser Ser Asp His Phe Gln Ala Val Pro Phe Asp Thr Glu Leu Val Asn 
    130                 135                 140                 


Leu Asp Gly Ala Phe Asp Leu Ala Ala Gly Arg Phe Leu Cys Thr Val 
145                 150                 155                 160 


Pro Gly Val Tyr Phe Leu Ser Leu Asn Val His Thr Trp Asn Tyr Lys 
                165                 170                 175     


Glu Thr Tyr Leu His Ile Met Leu Asn Arg Arg Pro Ala Ala Val Leu 
            180                 185                 190         


Tyr Ala Gln Pro Ser Glu Arg Ser Val Met Gln Ala Gln Ser Leu Met 
        195                 200                 205             


Leu Leu Leu Ala Ala Gly Asp Ala Val Trp Val Arg Met Phe Gln Arg 
    210                 215                 220                 


Asp Arg Asp Asn Ala Ile Tyr Gly Glu His Gly Asp Leu Tyr Ile Thr 
225                 230                 235                 240 


Phe Ser Gly His Leu Val Lys Pro Ala Ala Glu Leu 
                245                 250         


<210>  1811
<211>  333
<212>  PRT
<213>  Homo Sapiens

<400>  1811

Met Arg Ile Trp Trp Leu Leu Leu Ala Ile Glu Ile Cys Thr Gly Asn 
1               5                   10                  15      


Ile Asn Ser Gln Asp Thr Cys Arg Gln Gly His Pro Gly Ile Pro Gly 
            20                  25                  30          


Asn Pro Gly His Asn Gly Leu Pro Gly Arg Asp Gly Arg Asp Gly Ala 
        35                  40                  45              


Lys Gly Asp Lys Gly Asp Ala Gly Glu Pro Gly Arg Pro Gly Ser Pro 
    50                  55                  60                  


Gly Lys Asp Gly Thr Ser Gly Glu Lys Gly Glu Arg Gly Ala Asp Gly 
65                  70                  75                  80  


Lys Val Glu Ala Lys Gly Ile Lys Gly Asp Gln Gly Ser Arg Gly Ser 
                85                  90                  95      


Pro Gly Lys His Gly Pro Lys Gly Leu Ala Gly Pro Met Gly Glu Lys 
            100                 105                 110         


Gly Leu Arg Gly Glu Thr Gly Pro Gln Gly Gln Lys Gly Asn Lys Gly 
        115                 120                 125             


Asp Val Gly Pro Thr Gly Pro Glu Gly Pro Arg Gly Asn Ile Gly Pro 
    130                 135                 140                 


Leu Gly Pro Thr Gly Leu Pro Gly Pro Met Gly Pro Ile Gly Lys Pro 
145                 150                 155                 160 


Gly Pro Lys Gly Glu Ala Gly Pro Thr Gly Pro Gln Gly Glu Pro Gly 
                165                 170                 175     


Val Arg Gly Ile Arg Gly Trp Lys Gly Asp Arg Gly Glu Lys Gly Lys 
            180                 185                 190         


Ile Gly Glu Thr Leu Val Leu Pro Lys Ser Ala Phe Thr Val Gly Leu 
        195                 200                 205             


Thr Val Leu Ser Lys Phe Pro Ser Ser Asp Met Pro Ile Lys Phe Asp 
    210                 215                 220                 


Lys Ile Leu Tyr Asn Glu Phe Asn His Tyr Asp Thr Ala Ala Gly Lys 
225                 230                 235                 240 


Phe Thr Cys His Ile Ala Gly Val Tyr Tyr Phe Thr Tyr His Ile Thr 
                245                 250                 255     


Val Phe Ser Arg Asn Val Gln Val Ser Leu Val Lys Asn Gly Val Lys 
            260                 265                 270         


Ile Leu His Thr Lys Asp Ala Tyr Met Ser Ser Glu Asp Gln Ala Ser 
        275                 280                 285             


Gly Gly Ile Val Leu Gln Leu Lys Leu Gly Asp Glu Val Trp Leu Gln 
    290                 295                 300                 


Val Thr Gly Gly Glu Arg Phe Asn Gly Leu Phe Ala Asp Glu Asp Asp 
305                 310                 315                 320 


Asp Thr Thr Phe Thr Gly Phe Leu Leu Phe Ser Ser Pro 
                325                 330             


<210>  1812
<211>  333
<212>  PRT
<213>  Homo Sapiens

<400>  1812

Met Arg Ile Trp Trp Leu Leu Leu Ala Ile Glu Ile Cys Thr Gly Asn 
1               5                   10                  15      


Ile Asn Ser Gln Asp Thr Cys Arg Gln Gly His Pro Gly Ile Pro Gly 
            20                  25                  30          


Asn Pro Gly His Asn Gly Leu Pro Gly Arg Asp Gly Arg Asp Gly Ala 
        35                  40                  45              


Lys Gly Asp Lys Gly Asp Ala Gly Glu Pro Gly Arg Pro Gly Ser Pro 
    50                  55                  60                  


Gly Lys Asp Gly Thr Ser Gly Glu Lys Gly Glu Arg Gly Ala Asp Gly 
65                  70                  75                  80  


Lys Val Glu Ala Lys Gly Ile Lys Gly Asp Gln Gly Ser Arg Gly Ser 
                85                  90                  95      


Pro Gly Lys His Gly Pro Lys Gly Leu Ala Gly Pro Met Gly Glu Lys 
            100                 105                 110         


Gly Leu Arg Gly Glu Thr Gly Pro Gln Gly Gln Lys Gly Asn Lys Gly 
        115                 120                 125             


Asp Val Gly Pro Thr Gly Pro Glu Gly Pro Arg Gly Asn Ile Gly Pro 
    130                 135                 140                 


Leu Gly Pro Thr Gly Leu Pro Gly Pro Met Gly Pro Ile Gly Lys Pro 
145                 150                 155                 160 


Gly Pro Lys Gly Glu Ala Gly Pro Thr Gly Pro Gln Gly Glu Pro Gly 
                165                 170                 175     


Val Arg Gly Ile Arg Gly Trp Lys Gly Asp Arg Gly Glu Lys Gly Lys 
            180                 185                 190         


Ile Gly Glu Thr Leu Val Leu Pro Lys Ser Ala Phe Thr Val Gly Leu 
        195                 200                 205             


Thr Val Leu Ser Lys Phe Pro Ser Ser Asp Met Pro Ile Lys Phe Asp 
    210                 215                 220                 


Lys Ile Leu Tyr Asn Glu Phe Asn His Tyr Asp Thr Ala Ala Gly Lys 
225                 230                 235                 240 


Phe Thr Cys His Ile Ala Gly Val Tyr Tyr Phe Thr Tyr His Ile Thr 
                245                 250                 255     


Val Phe Ser Arg Asn Val Gln Val Ser Leu Val Lys Asn Gly Val Lys 
            260                 265                 270         


Ile Leu His Thr Lys Asp Ala Tyr Met Ser Ser Glu Asp Gln Ala Ser 
        275                 280                 285             


Gly Gly Ile Val Leu Gln Leu Lys Leu Gly Asp Glu Val Trp Leu Gln 
    290                 295                 300                 


Val Thr Gly Gly Glu Arg Phe Asn Gly Leu Phe Ala Asp Glu Asp Asp 
305                 310                 315                 320 


Asp Thr Thr Phe Thr Gly Phe Leu Leu Phe Ser Ser Pro 
                325                 330             


<210>  1813
<211>  333
<212>  PRT
<213>  Homo Sapiens

<400>  1813

Met Arg Ile Trp Trp Leu Leu Leu Ala Ile Glu Ile Cys Thr Gly Asn 
1               5                   10                  15      


Ile Asn Ser Gln Asp Thr Cys Arg Gln Gly His Pro Gly Ile Pro Gly 
            20                  25                  30          


Asn Pro Gly His Asn Gly Leu Pro Gly Arg Asp Gly Arg Asp Gly Ala 
        35                  40                  45              


Lys Gly Asp Lys Gly Asp Ala Gly Glu Pro Gly Cys Pro Gly Ser Pro 
    50                  55                  60                  


Gly Lys Asp Gly Thr Ser Gly Glu Lys Gly Glu Arg Gly Ala Asp Gly 
65                  70                  75                  80  


Lys Val Glu Ala Lys Gly Ile Lys Gly Asp Gln Gly Ser Arg Gly Ser 
                85                  90                  95      


Pro Gly Lys His Gly Pro Lys Gly Leu Ala Gly Pro Met Gly Glu Lys 
            100                 105                 110         


Gly Leu Arg Gly Glu Thr Gly Pro Gln Gly Gln Lys Gly Asn Lys Gly 
        115                 120                 125             


Asp Val Gly Pro Thr Gly Pro Glu Gly Pro Arg Gly Asn Ile Gly Pro 
    130                 135                 140                 


Leu Gly Pro Thr Gly Leu Pro Gly Pro Met Gly Pro Ile Gly Lys Pro 
145                 150                 155                 160 


Gly Pro Lys Gly Glu Ala Gly Pro Thr Gly Pro Gln Gly Glu Pro Gly 
                165                 170                 175     


Val Arg Gly Ile Arg Gly Trp Lys Gly Asp Arg Gly Glu Lys Gly Lys 
            180                 185                 190         


Ile Gly Glu Thr Leu Val Leu Pro Lys Ser Ala Phe Thr Val Gly Leu 
        195                 200                 205             


Thr Val Leu Ser Lys Phe Pro Ser Ser Asp Val Pro Ile Lys Phe Asp 
    210                 215                 220                 


Lys Ile Leu Tyr Asn Glu Phe Asn His Tyr Asp Thr Ala Val Gly Lys 
225                 230                 235                 240 


Phe Thr Cys His Ile Ala Gly Val Tyr Tyr Phe Thr Tyr His Ile Thr 
                245                 250                 255     


Val Phe Ser Arg Asn Val Gln Val Ser Leu Val Lys Asn Gly Val Lys 
            260                 265                 270         


Ile Leu His Thr Arg Asp Ala Tyr Val Ser Ser Glu Asp Gln Ala Ser 
        275                 280                 285             


Gly Ser Ile Val Leu Gln Leu Lys Leu Gly Asp Glu Met Trp Leu Gln 
    290                 295                 300                 


Val Thr Gly Gly Glu Arg Phe Asn Gly Leu Phe Ala Asp Glu Asp Asp 
305                 310                 315                 320 


Asp Thr Thr Phe Thr Gly Phe Leu Leu Phe Ser Ser Gln 
                325                 330             


<210>  1814
<211>  333
<212>  PRT
<213>  Homo Sapiens

<400>  1814

Met Arg Ile Trp Trp Leu Leu Leu Ala Ile Glu Ile Cys Thr Gly Asn 
1               5                   10                  15      


Ile Asn Ser Gln Asp Thr Cys Arg Gln Gly His Pro Gly Ile Pro Gly 
            20                  25                  30          


Asn Pro Gly His Asn Gly Leu Pro Gly Arg Asp Gly Arg Asp Gly Ala 
        35                  40                  45              


Lys Gly Asp Lys Gly Asp Ala Gly Glu Pro Gly Cys Pro Gly Ser Pro 
    50                  55                  60                  


Gly Lys Asp Gly Thr Ser Gly Glu Lys Gly Glu Arg Gly Ala Asp Gly 
65                  70                  75                  80  


Lys Val Glu Ala Lys Gly Ile Lys Gly Asp Gln Gly Ser Arg Gly Ser 
                85                  90                  95      


Pro Gly Lys His Gly Pro Lys Gly Leu Ala Gly Pro Met Gly Glu Lys 
            100                 105                 110         


Gly Leu Arg Gly Glu Thr Gly Pro Gln Gly Gln Lys Gly Asn Lys Gly 
        115                 120                 125             


Asp Val Gly Pro Thr Gly Pro Glu Gly Pro Arg Gly Asn Ile Gly Pro 
    130                 135                 140                 


Leu Gly Pro Thr Gly Leu Pro Gly Pro Met Gly Pro Ile Gly Lys Pro 
145                 150                 155                 160 


Gly Pro Lys Gly Glu Ala Gly Pro Thr Gly Pro Gln Gly Glu Pro Gly 
                165                 170                 175     


Val Arg Gly Ile Arg Gly Trp Lys Gly Asp Arg Gly Glu Lys Gly Lys 
            180                 185                 190         


Ile Gly Glu Thr Leu Val Leu Pro Lys Ser Ala Phe Thr Val Gly Leu 
        195                 200                 205             


Thr Val Leu Ser Lys Phe Pro Ser Ser Asp Val Pro Ile Lys Phe Asp 
    210                 215                 220                 


Lys Ile Leu Tyr Asn Glu Phe Asn His Tyr Asp Thr Ala Val Gly Lys 
225                 230                 235                 240 


Phe Thr Cys His Ile Ala Gly Val Tyr Tyr Phe Thr Tyr His Ile Thr 
                245                 250                 255     


Val Phe Ser Arg Asn Val Gln Val Ser Leu Val Lys Asn Gly Val Lys 
            260                 265                 270         


Ile Leu His Thr Arg Asp Ala Tyr Val Ser Ser Glu Asp Gln Ala Ser 
        275                 280                 285             


Gly Ser Ile Val Leu Gln Leu Lys Leu Gly Asp Glu Met Trp Leu Gln 
    290                 295                 300                 


Val Thr Gly Gly Glu Arg Phe Asn Gly Leu Phe Ala Asp Glu Asp Asp 
305                 310                 315                 320 


Asp Thr Thr Phe Thr Gly Phe Leu Leu Phe Ser Ser Gln 
                325                 330             


<210>  1815
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  1815

Met Arg Ile Trp Trp Leu Leu Leu Ala Ile Glu Ile Cys Thr Gly Asn 
1               5                   10                  15      


Ile Asn Ser Gln Asp Thr Cys Arg Gln Gly His Pro Gly Ile Pro Gly 
            20                  25                  30          


Asn Pro Gly His Asn Gly Leu Pro Gly Arg Asp Gly Arg Asp Gly Ala 
        35                  40                  45              


Lys Gly Asp Lys Gly Asp Ala Gly Glu Pro Gly Cys Pro Gly Ser Pro 
    50                  55                  60                  


Gly Lys Asp Gly Thr Ser Gly Glu Lys Gly Glu Arg Gly Ala Asp Gly 
65                  70                  75                  80  


Lys Val Glu Ala Lys Gly Ile Lys Gly Met Phe Arg Cys Leu Trp Ser 
                85                  90                  95      


Lys Thr Glu 
            


<210>  1816
<211>  49
<212>  PRT
<213>  Homo Sapiens

<400>  1816

Met Ser Gln Gly Asn Lys Met Leu Leu Thr Phe His Thr Asp Phe Ser 
1               5                   10                  15      


Asn Glu Glu Asn Gly Thr Ile Met Phe Tyr Lys Gly Phe Leu Ala Tyr 
            20                  25                  30          


Tyr Gln Ala Val Asp Leu Asp Glu Cys Ala Ser Arg Ser Lys Ser Gly 
        35                  40                  45              


Glu 
    


<210>  1817
<211>  72
<212>  PRT
<213>  Homo Sapiens

<400>  1817

Met Ser Gln Gly Asn Lys Met Leu Leu Thr Phe His Thr Asp Phe Ser 
1               5                   10                  15      


Asn Glu Glu Asn Gly Thr Ile Met Phe Tyr Lys Gly Phe Leu Ala Tyr 
            20                  25                  30          


Tyr Gln Ala Val Asp Leu Asp Glu Cys Ala Ser Arg Ser Lys Ser Gly 
        35                  40                  45              


Glu Glu Asp Pro Gln Pro Gln Cys Gln His Leu Cys His Asn Tyr Val 
    50                  55                  60                  


Gly Gly Tyr Phe Cys Ser Cys Arg 
65                  70          


<210>  1818
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  1818

Met Ser Gln Gly Asn Lys Met Leu Leu Thr Phe His Thr Asp Phe Ser 
1               5                   10                  15      


Asn Glu Glu Asn Gly Thr Ile Met Phe Tyr Lys Gly Phe Leu Ala Tyr 
            20                  25                  30          


Tyr Gln Ala Val Asp Leu Asp Glu Cys Ala Ser Arg Ser Lys Ser Gly 
        35                  40                  45              


Glu Glu Asp Pro Gln Pro Gln Cys Gln His Leu Cys His Asn Tyr Val 
    50                  55                  60                  


Gly Gly Tyr Phe Cys Ser Cys Arg Pro Gly Tyr Glu Leu Gln Glu Asp 
65                  70                  75                  80  


Arg His Ser Cys Gln Ala Glu Cys Ser Ser Glu Leu Tyr Thr 
                85                  90                  


<210>  1819
<211>  719
<212>  PRT
<213>  Homo Sapiens

<400>  1819

Met Ser Val Arg Phe Arg Val Gly Arg Glu Glu Asn Ala Gln Trp Trp 
1               5                   10                  15      


Leu Leu Tyr Leu Leu Val Pro Ala Leu Phe Cys Arg Ala Gly Gly Ser 
            20                  25                  30          


Ile Pro Ile Pro Gln Lys Leu Phe Gly Glu Val Thr Ser Pro Leu Phe 
        35                  40                  45              


Pro Lys Pro Tyr Pro Asn Asn Phe Glu Thr Thr Thr Val Ile Thr Val 
    50                  55                  60                  


Pro Thr Gly Tyr Arg Val Lys Leu Val Phe Gln Gln Phe Asp Leu Glu 
65                  70                  75                  80  


Pro Ser Glu Gly Cys Phe Tyr Asp Tyr Val Lys Ile Ser Ala Asp Lys 
                85                  90                  95      


Lys Ser Leu Gly Arg Phe Cys Gly Gln Leu Gly Ser Pro Leu Gly Asn 
            100                 105                 110         


Pro Pro Gly Lys Lys Glu Phe Met Ser Gln Gly Asn Lys Met Leu Leu 
        115                 120                 125             


Thr Phe His Thr Asp Phe Ser Asn Glu Glu Asn Gly Thr Ile Met Phe 
    130                 135                 140                 


Tyr Lys Gly Phe Leu Ala Tyr Tyr Gln Ala Val Asp Leu Asp Glu Cys 
145                 150                 155                 160 


Ala Ser Arg Ser Lys Ser Gly Glu Glu Asp Pro Gln Pro Gln Cys Gln 
                165                 170                 175     


His Leu Cys His Asn Tyr Val Gly Gly Tyr Phe Cys Ser Cys Arg Pro 
            180                 185                 190         


Gly Tyr Glu Leu Gln Glu Asp Arg His Ser Cys Gln Ala Glu Cys Ser 
        195                 200                 205             


Ser Glu Leu Tyr Thr Glu Ala Ser Gly Tyr Ile Ser Ser Leu Glu Tyr 
    210                 215                 220                 


Pro Arg Ser Tyr Pro Pro Asp Leu Arg Cys Asn Tyr Ser Ile Arg Val 
225                 230                 235                 240 


Glu Arg Gly Leu Thr Leu His Leu Lys Phe Leu Glu Pro Phe Asp Ile 
                245                 250                 255     


Asp Asp His Gln Gln Val His Cys Pro Tyr Asp Gln Leu Gln Ile Tyr 
            260                 265                 270         


Ala Asn Gly Lys Asn Ile Gly Glu Phe Cys Gly Lys Gln Arg Pro Pro 
        275                 280                 285             


Asp Leu Asp Thr Ser Ser Asn Ala Val Asp Leu Leu Phe Phe Thr Asp 
    290                 295                 300                 


Glu Ser Gly Asp Ser Arg Gly Trp Lys Leu Arg Tyr Thr Thr Glu Ile 
305                 310                 315                 320 


Ile Lys Cys Pro Gln Pro Lys Thr Leu Asp Glu Phe Thr Ile Ile Gln 
                325                 330                 335     


Asn Leu Gln Pro Gln Tyr Gln Phe Arg Asp Tyr Phe Ile Ala Thr Cys 
            340                 345                 350         


Lys Gln Gly Tyr Gln Leu Ile Glu Gly Asn Gln Val Leu His Ser Phe 
        355                 360                 365             


Thr Ala Val Cys Gln Asp Asp Gly Thr Trp His Arg Ala Met Pro Arg 
    370                 375                 380                 


Cys Lys Ile Lys Asp Cys Gly Gln Pro Arg Asn Leu Pro Asn Gly Asp 
385                 390                 395                 400 


Phe Arg Tyr Thr Thr Thr Met Gly Val Asn Thr Tyr Lys Ala Arg Ile 
                405                 410                 415     


Gln Tyr Tyr Cys His Glu Pro Tyr Tyr Lys Met Gln Thr Arg Ala Gly 
            420                 425                 430         


Ser Arg Glu Ser Glu Gln Gly Val Tyr Thr Cys Thr Ala Gln Gly Ile 
        435                 440                 445             


Trp Lys Asn Glu Gln Lys Gly Glu Lys Ile Pro Arg Cys Leu Pro Val 
    450                 455                 460                 


Cys Gly Lys Pro Val Asn Pro Val Glu Gln Arg Gln Arg Ile Ile Gly 
465                 470                 475                 480 


Gly Gln Lys Ala Lys Met Gly Asn Phe Pro Trp Gln Val Phe Thr Asn 
                485                 490                 495     


Ile His Gly Arg Gly Gly Gly Ala Leu Leu Gly Asp Arg Trp Ile Leu 
            500                 505                 510         


Thr Ala Ala His Thr Leu Tyr Pro Lys Glu His Glu Ala Gln Ser Asn 
        515                 520                 525             


Ala Ser Leu Asp Val Phe Leu Gly His Thr Asn Val Glu Glu Leu Met 
    530                 535                 540                 


Lys Leu Gly Asn His Pro Ile Arg Arg Val Ser Val His Pro Asp Tyr 
545                 550                 555                 560 


Arg Gln Asp Glu Ser Tyr Asn Phe Glu Gly Asp Ile Ala Leu Leu Glu 
                565                 570                 575     


Leu Glu Asn Ser Val Thr Leu Gly Pro Asn Leu Leu Pro Ile Cys Leu 
            580                 585                 590         


Pro Asp Asn Asp Thr Phe Tyr Asp Leu Gly Leu Met Gly Tyr Val Ser 
        595                 600                 605             


Gly Phe Gly Val Met Glu Glu Lys Ile Ala His Asp Leu Arg Phe Val 
    610                 615                 620                 


Arg Leu Pro Val Ala Asn Pro Gln Ala Cys Glu Asn Trp Leu Arg Gly 
625                 630                 635                 640 


Lys Asn Arg Met Asp Val Phe Ser Gln Asn Met Phe Cys Ala Gly His 
                645                 650                 655     


Pro Ser Leu Lys Gln Asp Ala Cys Gln Gly Asp Ser Gly Gly Val Phe 
            660                 665                 670         


Ala Val Arg Asp Pro Asn Thr Asp Arg Trp Val Ala Thr Gly Ile Val 
        675                 680                 685             


Ser Trp Gly Ile Gly Cys Ser Arg Gly Tyr Gly Phe Tyr Thr Lys Val 
    690                 695                 700                 


Leu Asn Tyr Val Asp Trp Ile Lys Lys Glu Met Glu Glu Glu Asp 
705                 710                 715                 


<210>  1820
<211>  705
<212>  PRT
<213>  Homo Sapiens

<400>  1820

Met Trp Leu Leu Tyr Leu Leu Val Pro Ala Leu Phe Cys Arg Ala Gly 
1               5                   10                  15      


Gly Ser Ile Pro Ile Pro Gln Lys Leu Phe Gly Glu Val Thr Ser Pro 
            20                  25                  30          


Leu Phe Pro Lys Pro Tyr Pro Asn Asn Phe Glu Thr Thr Thr Val Ile 
        35                  40                  45              


Thr Val Pro Thr Gly Tyr Arg Val Lys Leu Val Phe Gln Gln Phe Asp 
    50                  55                  60                  


Leu Glu Pro Ser Glu Gly Cys Phe Tyr Asp Tyr Val Lys Ile Ser Ala 
65                  70                  75                  80  


Asp Lys Lys Ser Leu Gly Arg Phe Cys Gly Gln Leu Gly Ser Pro Leu 
                85                  90                  95      


Gly Asn Pro Pro Gly Lys Lys Glu Phe Met Ser Gln Gly Asn Lys Met 
            100                 105                 110         


Leu Leu Thr Phe His Thr Asp Phe Ser Asn Glu Glu Asn Gly Thr Ile 
        115                 120                 125             


Met Phe Tyr Lys Gly Phe Leu Ala Tyr Tyr Gln Ala Val Asp Leu Asp 
    130                 135                 140                 


Glu Cys Ala Ser Arg Ser Lys Ser Gly Glu Glu Asp Pro Gln Pro Gln 
145                 150                 155                 160 


Cys Gln His Leu Cys His Asn Tyr Val Gly Gly Tyr Phe Cys Ser Cys 
                165                 170                 175     


Arg Pro Gly Tyr Glu Leu Gln Glu Asp Arg His Ser Cys Gln Ala Glu 
            180                 185                 190         


Cys Ser Ser Glu Leu Tyr Thr Glu Ala Ser Gly Tyr Ile Ser Ser Leu 
        195                 200                 205             


Glu Tyr Pro Arg Ser Tyr Pro Pro Asp Leu Arg Cys Asn Tyr Ser Ile 
    210                 215                 220                 


Arg Val Glu Arg Gly Leu Thr Leu His Leu Lys Phe Leu Glu Pro Phe 
225                 230                 235                 240 


Asp Ile Asp Asp His Gln Gln Val His Cys Pro Tyr Asp Gln Leu Gln 
                245                 250                 255     


Ile Tyr Ala Asn Gly Lys Asn Ile Gly Glu Phe Cys Gly Lys Gln Arg 
            260                 265                 270         


Pro Pro Asp Leu Asp Thr Ser Ser Asn Ala Val Asp Leu Leu Phe Phe 
        275                 280                 285             


Thr Asp Glu Ser Gly Asp Ser Arg Gly Trp Lys Leu Arg Tyr Thr Thr 
    290                 295                 300                 


Glu Ile Ile Lys Cys Pro Gln Pro Lys Thr Leu Asp Glu Phe Thr Ile 
305                 310                 315                 320 


Ile Gln Asn Leu Gln Pro Gln Tyr Gln Phe Arg Asp Tyr Phe Ile Ala 
                325                 330                 335     


Thr Cys Lys Gln Gly Tyr Gln Leu Ile Glu Gly Asn Gln Val Leu His 
            340                 345                 350         


Ser Phe Thr Ala Val Cys Gln Asp Asp Gly Thr Trp His Arg Ala Met 
        355                 360                 365             


Pro Arg Cys Lys Ile Lys Asp Cys Gly Gln Pro Arg Asn Leu Pro Asn 
    370                 375                 380                 


Gly Asp Phe Arg Tyr Thr Thr Thr Met Gly Val Asn Thr Tyr Lys Ala 
385                 390                 395                 400 


Arg Ile Gln Tyr Tyr Cys His Glu Pro Tyr Tyr Lys Met Gln Thr Arg 
                405                 410                 415     


Ala Gly Ser Arg Glu Ser Glu Gln Gly Val Tyr Thr Cys Thr Ala Gln 
            420                 425                 430         


Gly Ile Trp Lys Asn Glu Gln Lys Gly Glu Lys Ile Pro Arg Cys Leu 
        435                 440                 445             


Pro Val Cys Gly Lys Pro Val Asn Pro Val Glu Gln Arg Gln Arg Ile 
    450                 455                 460                 


Ile Gly Gly Gln Lys Ala Lys Met Gly Asn Phe Pro Trp Gln Val Phe 
465                 470                 475                 480 


Thr Asn Ile His Gly Arg Gly Gly Gly Ala Leu Leu Gly Asp Arg Trp 
                485                 490                 495     


Ile Leu Thr Ala Ala His Thr Leu Tyr Pro Lys Glu His Glu Ala Gln 
            500                 505                 510         


Ser Asn Ala Ser Leu Asp Val Phe Leu Gly His Thr Asn Val Glu Glu 
        515                 520                 525             


Leu Met Lys Leu Gly Asn His Pro Ile Arg Arg Val Ser Val His Pro 
    530                 535                 540                 


Asp Tyr Arg Gln Asp Glu Ser Tyr Asn Phe Glu Gly Asp Ile Ala Leu 
545                 550                 555                 560 


Leu Glu Leu Glu Asn Ser Val Thr Leu Gly Pro Asn Leu Leu Pro Ile 
                565                 570                 575     


Cys Leu Pro Asp Asn Asp Thr Phe Tyr Asp Leu Gly Leu Met Gly Tyr 
            580                 585                 590         


Val Ser Gly Phe Gly Val Met Glu Glu Lys Ile Ala His Asp Leu Arg 
        595                 600                 605             


Phe Val Arg Leu Pro Val Ala Asn Pro Gln Ala Cys Glu Asn Trp Leu 
    610                 615                 620                 


Arg Gly Lys Asn Arg Met Asp Val Phe Ser Gln Asn Met Phe Cys Ala 
625                 630                 635                 640 


Gly His Pro Ser Leu Lys Gln Asp Ala Cys Gln Gly Asp Ser Gly Gly 
                645                 650                 655     


Val Phe Ala Val Arg Asp Pro Asn Thr Asp Arg Trp Val Ala Thr Gly 
            660                 665                 670         


Ile Val Ser Trp Gly Ile Gly Cys Ser Arg Gly Tyr Gly Phe Tyr Thr 
        675                 680                 685             


Lys Val Leu Asn Tyr Val Asp Trp Ile Lys Lys Glu Met Glu Glu Glu 
    690                 695                 700                 


Asp 
705 


<210>  1821
<211>  156
<212>  PRT
<213>  Homo Sapiens

<400>  1821

Met Trp Leu Leu Tyr Leu Leu Val Pro Ala Leu Phe Cys Arg Ala Gly 
1               5                   10                  15      


Gly Ser Ile Pro Ile Pro Gln Lys Leu Phe Gly Glu Val Thr Ser Pro 
            20                  25                  30          


Leu Phe Pro Lys Pro Tyr Pro Asn Asn Phe Glu Thr Thr Thr Val Ile 
        35                  40                  45              


Thr Val Pro Thr Gly Tyr Arg Val Lys Leu Val Phe Gln Gln Phe Asp 
    50                  55                  60                  


Leu Glu Pro Ser Glu Gly Cys Phe Tyr Asp Tyr Val Lys Ile Ser Ala 
65                  70                  75                  80  


Asp Lys Lys Ser Leu Gly Arg Phe Cys Gly Gln Leu Gly Ser Pro Leu 
                85                  90                  95      


Gly Asn Pro Pro Gly Lys Lys Glu Phe Met Ser Gln Gly Asn Lys Met 
            100                 105                 110         


Leu Leu Thr Phe His Thr Asp Phe Ser Asn Glu Glu Asn Gly Thr Ile 
        115                 120                 125             


Met Phe Tyr Lys Gly Phe Leu Ala Tyr Tyr Gln Ala Val Gly Glu Glu 
    130                 135                 140                 


Asp Pro Gln Pro Gln Cys Gln His Leu Cys His Asn 
145                 150                 155     


<210>  1822
<211>  144
<212>  PRT
<213>  Homo Sapiens

<400>  1822

Met Trp Leu Leu Tyr Leu Leu Val Pro Ala Leu Phe Cys Arg Ala Gly 
1               5                   10                  15      


Gly Ser Ile Pro Ile Pro Gln Lys Leu Phe Gly Glu Val Thr Ser Pro 
            20                  25                  30          


Leu Phe Pro Lys Pro Tyr Pro Asn Asn Phe Glu Thr Thr Thr Val Ile 
        35                  40                  45              


Thr Val Pro Thr Gly Tyr Arg Val Lys Leu Val Phe Gln Gln Phe Asp 
    50                  55                  60                  


Leu Glu Pro Ser Glu Gly Cys Phe Tyr Asp Tyr Val Lys Ile Ser Ala 
65                  70                  75                  80  


Asp Lys Lys Ser Leu Gly Arg Phe Cys Gly Gln Leu Gly Ser Pro Leu 
                85                  90                  95      


Gly Asn Pro Pro Gly Lys Lys Glu Phe Met Ser Gln Gly Asn Lys Met 
            100                 105                 110         


Leu Leu Thr Phe His Thr Asp Phe Ser Asn Glu Glu Asn Gly Thr Ile 
        115                 120                 125             


Met Phe Tyr Lys Gly Phe Leu Ala Tyr Tyr Gln Ala Val Gly Leu Trp 
    130                 135                 140                 


<210>  1823
<211>  156
<212>  PRT
<213>  Homo Sapiens

<400>  1823

Met Trp Leu Leu Tyr Leu Leu Val Pro Ala Leu Phe Cys Arg Ala Gly 
1               5                   10                  15      


Gly Ser Ile Pro Ile Pro Gln Lys Leu Phe Gly Glu Val Thr Ser Pro 
            20                  25                  30          


Leu Phe Pro Lys Pro Tyr Pro Asn Asn Phe Glu Thr Thr Thr Val Ile 
        35                  40                  45              


Thr Val Pro Thr Gly Tyr Arg Val Lys Leu Val Phe Gln Gln Phe Asp 
    50                  55                  60                  


Leu Glu Pro Ser Glu Gly Cys Phe Tyr Asp Tyr Val Lys Lys Glu Phe 
65                  70                  75                  80  


Met Ser Gln Gly Asn Lys Met Leu Leu Thr Phe His Thr Asp Phe Ser 
                85                  90                  95      


Asn Glu Glu Asn Gly Thr Ile Met Phe Tyr Lys Gly Phe Leu Ala Tyr 
            100                 105                 110         


Tyr Gln Ala Val Asp Leu Asp Glu Cys Ala Ser Arg Ser Lys Ser Gly 
        115                 120                 125             


Glu Glu Asp Pro Gln Pro Gln Cys Gln His Leu Cys His Asn Tyr Val 
    130                 135                 140                 


Gly Gly Tyr Phe Cys Ser Cys Arg Pro Gly Tyr Glu 
145                 150                 155     


<210>  1824
<211>  671
<212>  PRT
<213>  Homo Sapiens

<400>  1824

Met Trp Leu Leu Tyr Leu Leu Val Pro Ala Leu Phe Cys Arg Ala Gly 
1               5                   10                  15      


Gly Ser Ile Pro Ile Pro Gln Lys Leu Phe Gly Glu Val Thr Ser Pro 
            20                  25                  30          


Leu Phe Pro Lys Pro Tyr Pro Asn Asn Phe Glu Thr Thr Thr Val Ile 
        35                  40                  45              


Thr Val Pro Thr Gly Tyr Arg Val Lys Leu Val Phe Gln Gln Phe Asp 
    50                  55                  60                  


Leu Glu Pro Ser Glu Gly Cys Phe Tyr Asp Tyr Val Lys Met Leu Leu 
65                  70                  75                  80  


Thr Phe His Thr Asp Phe Ser Asn Glu Glu Asn Gly Thr Ile Met Phe 
                85                  90                  95      


Tyr Lys Gly Phe Leu Ala Tyr Tyr Gln Ala Val Asp Leu Asp Glu Cys 
            100                 105                 110         


Ala Ser Arg Ser Lys Ser Gly Glu Glu Asp Pro Gln Pro Gln Cys Gln 
        115                 120                 125             


His Leu Cys His Asn Tyr Val Gly Gly Tyr Phe Cys Ser Cys Arg Pro 
    130                 135                 140                 


Gly Tyr Glu Leu Gln Glu Asp Arg His Ser Cys Gln Ala Glu Cys Ser 
145                 150                 155                 160 


Ser Glu Leu Tyr Thr Glu Ala Ser Gly Tyr Ile Ser Ser Leu Glu Tyr 
                165                 170                 175     


Pro Arg Ser Tyr Pro Pro Asp Leu Arg Cys Asn Tyr Ser Ile Arg Val 
            180                 185                 190         


Glu Arg Gly Leu Thr Leu His Leu Lys Phe Leu Glu Pro Phe Asp Ile 
        195                 200                 205             


Asp Asp His Gln Gln Val His Cys Pro Tyr Asp Gln Leu Gln Ile Tyr 
    210                 215                 220                 


Ala Asn Gly Lys Asn Ile Gly Glu Phe Cys Gly Lys Gln Arg Pro Pro 
225                 230                 235                 240 


Asp Leu Asp Thr Ser Ser Asn Ala Val Asp Leu Leu Phe Phe Thr Asp 
                245                 250                 255     


Glu Ser Gly Asp Ser Arg Gly Trp Lys Leu Arg Tyr Thr Thr Glu Ile 
            260                 265                 270         


Ile Lys Cys Pro Gln Pro Lys Thr Leu Asp Glu Phe Thr Ile Ile Gln 
        275                 280                 285             


Asn Leu Gln Pro Gln Tyr Gln Phe Arg Asp Tyr Phe Ile Ala Thr Cys 
    290                 295                 300                 


Lys Gln Gly Tyr Gln Leu Ile Glu Gly Asn Gln Val Leu His Ser Phe 
305                 310                 315                 320 


Thr Ala Val Cys Gln Asp Asp Gly Thr Trp His Arg Ala Met Pro Arg 
                325                 330                 335     


Cys Lys Ile Lys Asp Cys Gly Gln Pro Arg Asn Leu Pro Asn Gly Asp 
            340                 345                 350         


Phe Arg Tyr Thr Thr Thr Met Gly Val Asn Thr Tyr Lys Ala Arg Ile 
        355                 360                 365             


Gln Tyr Tyr Cys His Glu Pro Tyr Tyr Lys Met Gln Thr Arg Ala Gly 
    370                 375                 380                 


Ser Arg Glu Ser Glu Gln Gly Val Tyr Thr Cys Thr Ala Gln Gly Ile 
385                 390                 395                 400 


Trp Lys Asn Glu Gln Lys Gly Glu Lys Ile Pro Arg Cys Leu Pro Val 
                405                 410                 415     


Cys Gly Lys Pro Val Asn Pro Val Glu Gln Arg Gln Arg Ile Ile Gly 
            420                 425                 430         


Gly Gln Lys Ala Lys Met Gly Asn Phe Pro Trp Gln Val Phe Thr Asn 
        435                 440                 445             


Ile His Gly Arg Gly Gly Gly Ala Leu Leu Gly Asp Arg Trp Ile Leu 
    450                 455                 460                 


Thr Ala Ala His Thr Leu Tyr Pro Lys Glu His Glu Ala Gln Ser Asn 
465                 470                 475                 480 


Ala Ser Leu Asp Val Phe Leu Gly His Thr Asn Val Glu Glu Leu Met 
                485                 490                 495     


Lys Leu Gly Asn His Pro Ile Arg Arg Val Ser Val His Pro Asp Tyr 
            500                 505                 510         


Arg Gln Asp Glu Ser Tyr Asn Phe Glu Gly Asp Ile Ala Leu Leu Glu 
        515                 520                 525             


Leu Glu Asn Ser Val Thr Leu Gly Pro Asn Leu Leu Pro Ile Cys Leu 
    530                 535                 540                 


Pro Asp Asn Asp Thr Phe Tyr Asp Leu Gly Leu Met Gly Tyr Val Ser 
545                 550                 555                 560 


Gly Phe Gly Val Met Glu Glu Lys Ile Ala His Asp Leu Arg Phe Val 
                565                 570                 575     


Arg Leu Pro Val Ala Asn Pro Gln Ala Cys Glu Asn Trp Leu Arg Gly 
            580                 585                 590         


Lys Asn Arg Met Asp Val Phe Ser Gln Asn Met Phe Cys Ala Gly His 
        595                 600                 605             


Pro Ser Leu Lys Gln Asp Ala Cys Gln Gly Asp Ser Gly Gly Val Phe 
    610                 615                 620                 


Ala Val Arg Asp Pro Asn Thr Asp Arg Trp Val Ala Thr Gly Ile Val 
625                 630                 635                 640 


Ser Trp Gly Ile Gly Cys Ser Arg Gly Tyr Gly Phe Tyr Thr Lys Val 
                645                 650                 655     


Leu Asn Tyr Val Asp Trp Ile Lys Lys Glu Met Glu Glu Glu Asp 
            660                 665                 670     


<210>  1825
<211>  83
<212>  PRT
<213>  Homo Sapiens

<400>  1825

Gly Leu Arg Pro Gly Ala Val Pro Gly Leu Cys Arg Gly Leu Cys His 
1               5                   10                  15      


Asn Leu Ile Arg Arg Phe Gly Ser Lys Pro Val Leu Trp Ser Ala Arg 
            20                  25                  30          


Leu Pro Ser Gly Gln Ala Pro Trp Ser Glu Gly Val Cys Ile Leu Arg 
        35                  40                  45              


Glu Glu Phe Ala Ala Asp Leu Pro His Thr Ala Phe Leu Gly Glu Gln 
    50                  55                  60                  


Asp Cys Pro Pro Pro Gln Gly Leu Pro Gly Pro Leu Pro Asn Arg Gly 
65                  70                  75                  80  


Cys Glu Leu 
            


<210>  1826
<211>  110
<212>  PRT
<213>  Homo Sapiens

<400>  1826

Met Pro Gly Pro Arg Val Trp Gly Lys Tyr Leu Trp Arg Ser Pro His 
1               5                   10                  15      


Ser Lys Gly Cys Pro Gly Ala Ile Ser His Ser Ser Val Arg Ile Gln 
            20                  25                  30          


Ala Ser Ser Val Val Ser Lys Ala Pro Leu Trp Ala Gly Pro Leu Val 
        35                  40                  45              


Arg Gly Ser Phe Gln Pro Ile Ser Glu Ala Ser Arg Gly Ser Glu Ala 
    50                  55                  60                  


Ile Asn Ala Pro Gly Asp Asn Pro Ala Lys Val Gln Asn His Cys Gln 
65                  70                  75                  80  


Glu Pro Tyr Tyr Gln Ala Ala Ala Ala Gly Cys Gly Ser Tyr Ala Asp 
                85                  90                  95      


Pro Ile Thr Asp Gln Pro Ser Val Arg Phe Ser Pro Gln Leu 
            100                 105                 110 


<210>  1827
<211>  314
<212>  PRT
<213>  Homo Sapiens

<400>  1827

Met Pro Gly Pro Arg Val Trp Gly Lys Tyr Leu Trp Arg Ser Pro His 
1               5                   10                  15      


Ser Lys Gly Cys Pro Gly Ala Met Trp Trp Leu Leu Leu Trp Gly Val 
            20                  25                  30          


Leu Gln Ala Cys Pro Thr Arg Gly Ser Val Leu Leu Ala Gln Glu Leu 
        35                  40                  45              


Pro Gln Gln Leu Thr Ser Pro Gly Tyr Pro Glu Pro Tyr Gly Lys Gly 
    50                  55                  60                  


Gln Glu Ser Ser Thr Asp Ile Lys Ala Pro Glu Gly Phe Ala Val Arg 
65                  70                  75                  80  


Leu Val Phe Gln Asp Phe Asp Leu Glu Pro Ser Gln Asp Cys Ala Gly 
                85                  90                  95      


Asp Ser Val Thr Ile Ser Phe Val Gly Ser Asp Pro Ser Gln Phe Cys 
            100                 105                 110         


Gly Gln Gln Gly Ser Pro Leu Gly Arg Pro Pro Gly Gln Arg Glu Phe 
        115                 120                 125             


Val Ser Ser Gly Arg Ser Leu Arg Leu Thr Phe Arg Thr Gln Pro Ser 
    130                 135                 140                 


Ser Glu Asn Lys Thr Ala His Leu His Lys Gly Phe Leu Ala Leu Tyr 
145                 150                 155                 160 


Gln Thr Val Ala Val Asn Tyr Ser Gln Pro Ile Ser Glu Ala Ser Arg 
                165                 170                 175     


Gly Ser Glu Ala Ile Asn Ala Pro Gly Asp Asn Pro Ala Lys Val Gln 
            180                 185                 190         


Asn His Cys Gln Glu Pro Tyr Tyr Gln Ala Ala Ala Ala Ala Ser Thr 
        195                 200                 205             


Pro Ser Leu Phe Leu Cys Leu Ser Ser Phe Thr Pro Gln Gly His Ser 
    210                 215                 220                 


Pro Val Gln Pro Gln Gly Pro Gly Lys Thr Asp Arg Met Gly Arg Arg 
225                 230                 235                 240 


Phe Phe Ser Val Cys Leu Ser Ala Asp Gly Gln Ser Pro Pro Leu Pro 
                245                 250                 255     


Arg Ile Arg Arg Pro Ser Val Leu Pro Glu Pro Ser Trp Ala Thr Ser 
            260                 265                 270         


Pro Gly Lys Pro Ser Pro Val Ser Thr Ala Val Gly Ala Gly Pro Cys 
        275                 280                 285             


Trp Gly Thr Asp Gly Ser Ser Leu Leu Pro Thr Pro Ser Thr Pro Arg 
    290                 295                 300                 


Thr Val Phe Leu Ser Gly Arg Thr Arg Val 
305                 310                 


<210>  1828
<211>  487
<212>  PRT
<213>  Homo Sapiens

<400>  1828

Met Pro Gly Pro Arg Val Trp Gly Lys Tyr Leu Trp Arg Ser Pro His 
1               5                   10                  15      


Ser Lys Gly Cys Pro Gly Ala Met Trp Trp Leu Leu Leu Trp Gly Val 
            20                  25                  30          


Leu Gln Ala Cys Pro Thr Arg Gly Ser Val Leu Leu Ala Gln Glu Leu 
        35                  40                  45              


Pro Gln Gln Leu Thr Ser Pro Gly Tyr Pro Glu Pro Tyr Gly Lys Gly 
    50                  55                  60                  


Gln Glu Ser Ser Thr Asp Ile Lys Ala Pro Glu Gly Phe Ala Val Arg 
65                  70                  75                  80  


Leu Val Phe Gln Asp Phe Asp Leu Glu Pro Ser Gln Asp Cys Ala Gly 
                85                  90                  95      


Asp Ser Val Thr Ile Ser Phe Val Gly Ser Asp Pro Ser Gln Phe Cys 
            100                 105                 110         


Gly Gln Gln Gly Ser Pro Leu Gly Arg Pro Pro Gly Gln Arg Glu Phe 
        115                 120                 125             


Val Ser Ser Gly Arg Ser Leu Arg Leu Thr Phe Arg Thr Gln Pro Ser 
    130                 135                 140                 


Ser Glu Asn Lys Thr Ala His Leu His Lys Gly Phe Leu Ala Leu Tyr 
145                 150                 155                 160 


Gln Thr Val Ala Val Asn Tyr Ser Gln Pro Ile Ser Glu Ala Ser Arg 
                165                 170                 175     


Gly Ser Glu Ala Ile Asn Ala Pro Gly Asp Asn Pro Ala Lys Val Gln 
            180                 185                 190         


Asn His Cys Gln Glu Pro Tyr Tyr Gln Ala Ala Ala Ala Gly Ala Leu 
        195                 200                 205             


Thr Cys Ala Thr Pro Gly Thr Trp Lys Asp Arg Gln Asp Gly Glu Glu 
    210                 215                 220                 


Val Leu Gln Cys Met Pro Val Cys Gly Arg Pro Val Thr Pro Ile Ala 
225                 230                 235                 240 


Gln Asn Gln Thr Thr Leu Gly Ser Ser Arg Ala Lys Leu Gly Asn Phe 
                245                 250                 255     


Pro Trp Gln Ala Phe Thr Ser Ile His Gly Arg Gly Gly Gly Ala Leu 
            260                 265                 270         


Leu Gly Asp Arg Trp Ile Leu Thr Ala Ala His Thr Ile Tyr Pro Lys 
        275                 280                 285             


Asp Ser Val Ser Leu Arg Lys Asn Gln Ser Val Asn Val Phe Leu Gly 
    290                 295                 300                 


His Thr Ala Ile Asp Glu Met Leu Lys Leu Gly Asn His Pro Val His 
305                 310                 315                 320 


Arg Val Val Val His Pro Asp Tyr Arg Gln Asn Glu Ser His Asn Phe 
                325                 330                 335     


Ser Gly Asp Ile Ala Leu Leu Glu Leu Gln His Ser Ile Pro Leu Gly 
            340                 345                 350         


Pro Asn Val Leu Pro Val Cys Leu Pro Asp Asn Glu Thr Leu Tyr Arg 
        355                 360                 365             


Ser Gly Leu Leu Gly Tyr Val Ser Gly Phe Gly Met Glu Met Gly Trp 
    370                 375                 380                 


Leu Thr Thr Glu Leu Lys Tyr Ser Arg Leu Pro Val Ala Pro Arg Glu 
385                 390                 395                 400 


Ala Cys Asn Ala Trp Leu Gln Lys Arg Gln Arg Pro Glu Val Phe Ser 
                405                 410                 415     


Asp Asn Met Phe Cys Val Gly Asp Glu Thr Gln Arg His Ser Val Cys 
            420                 425                 430         


Gln Gly Asp Ser Gly Ser Val Tyr Val Val Trp Asp Asn His Ala His 
        435                 440                 445             


His Trp Val Ala Thr Gly Ile Val Ser Trp Gly Ile Gly Cys Gly Glu 
    450                 455                 460                 


Gly Tyr Asp Phe Tyr Thr Lys Val Leu Ser Tyr Val Asp Trp Ile Lys 
465                 470                 475                 480 


Gly Val Met Asn Gly Lys Asn 
                485         


<210>  1829
<211>  192
<212>  PRT
<213>  Homo Sapiens

<400>  1829

Met Pro Gly Pro Arg Val Trp Gly Lys Tyr Leu Trp Arg Ser Pro His 
1               5                   10                  15      


Ser Lys Gly Cys Pro Gly Ala Met Trp Trp Leu Leu Leu Trp Gly Val 
            20                  25                  30          


Leu Gln Ala Cys Pro Thr Arg Gly Ser Val Leu Leu Ala Gln Glu Leu 
        35                  40                  45              


Pro Gln Gln Leu Thr Ser Pro Gly Tyr Pro Glu Pro Tyr Gly Lys Gly 
    50                  55                  60                  


Gln Glu Ser Ser Thr Asp Ile Lys Ala Pro Glu Gly Phe Ala Val Arg 
65                  70                  75                  80  


Leu Val Phe Gln Asp Phe Asp Leu Glu Pro Ser Gln Asp Cys Ala Gly 
                85                  90                  95      


Asp Ser Val Thr Ile Ser Phe Val Gly Ser Asp Pro Ser Gln Phe Cys 
            100                 105                 110         


Gly Gln Gln Gly Ser Pro Leu Gly Arg Pro Pro Gly Gln Arg Glu Phe 
        115                 120                 125             


Val Ser Ser Gly Arg Ser Leu Arg Leu Thr Phe Arg Thr Gln Pro Ser 
    130                 135                 140                 


Ser Glu Asn Lys Thr Ala His Leu His Lys Gly Phe Leu Ala Leu Tyr 
145                 150                 155                 160 


Gln Thr Val Gly Ala Leu Thr Cys Ala Thr Pro Gly Thr Trp Lys Asp 
                165                 170                 175     


Arg Gln Asp Gly Glu Glu Val Leu Gln Cys Met Pro Val Cys Gly Arg 
            180                 185                 190         


<210>  1830
<211>  187
<212>  PRT
<213>  Homo Sapiens

<400>  1830

Met Pro Gly Pro Arg Val Trp Gly Lys Tyr Leu Trp Arg Ser Pro His 
1               5                   10                  15      


Ser Lys Gly Cys Pro Gly Ala Met Trp Trp Leu Leu Leu Trp Gly Val 
            20                  25                  30          


Leu Gln Ala Cys Pro Thr Arg Gly Ser Val Leu Leu Ala Gln Glu Leu 
        35                  40                  45              


Pro Gln Gln Leu Thr Ser Pro Gly Tyr Pro Glu Pro Tyr Gly Lys Gly 
    50                  55                  60                  


Gln Glu Ser Ser Thr Asp Ile Lys Ala Pro Glu Gly Phe Ala Val Arg 
65                  70                  75                  80  


Leu Val Phe Gln Asp Phe Asp Leu Glu Pro Ser Gln Asp Cys Ala Gly 
                85                  90                  95      


Asp Ser Val Thr Ile Ser Phe Val Gly Ser Asp Pro Ser Gln Phe Cys 
            100                 105                 110         


Gly Gln Gln Gly Ser Pro Leu Gly Arg Pro Pro Gly Gln Arg Glu Phe 
        115                 120                 125             


Val Ser Ser Gly Arg Ser Leu Arg Leu Thr Phe Arg Thr Gln Pro Ser 
    130                 135                 140                 


Ser Glu Asn Lys Thr Ala His Leu His Lys Gly Phe Leu Ala Leu Tyr 
145                 150                 155                 160 


Gln Thr Val Gly Glu Cys Pro Ser Trp Gly Cys Arg Glu Gly Ala Ser 
                165                 170                 175     


Val Pro Ser His Asp Pro Gly Ile Phe Lys Pro 
            180                 185         


<210>  1831
<211>  66
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1831

Xaa Asn Pro Ala Lys Val Gln Asn His Cys Gln Glu Pro Tyr Tyr Gln 
1               5                   10                  15      


Ala Ala Ala Ala Gly Ala Leu Thr Cys Ala Thr Pro Gly Thr Trp Lys 
            20                  25                  30          


Asp Arg Gln Asp Gly Glu Glu Val Leu Gln Cys Met Pro Gly Cys Gly 
        35                  40                  45              


Ser Tyr Ala Asp Pro Ile Thr Asp Gln Pro Ser Val Arg Phe Ser Pro 
    50                  55                  60                  


Gln Leu 
65      


<210>  1832
<211>  85
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1832

Xaa Pro Gly Leu Arg Pro Gly Ala Val Pro Gly Leu Cys Arg Gly Leu 
1               5                   10                  15      


Cys His Asn Leu Ile Arg Arg Phe Gly Ser Lys Pro Val Leu Trp Ser 
            20                  25                  30          


Ala Arg Leu Pro Ser Gly Gln Ala Pro Trp Ser Glu Gly Val Cys Ile 
        35                  40                  45              


Leu Arg Glu Glu Phe Ala Ala Asp Leu Pro His Thr Ala Phe Leu Gly 
    50                  55                  60                  


Glu Gln Asp Cys Pro Pro Pro Gln Gly Leu Pro Gly Pro Leu Pro Asn 
65                  70                  75                  80  


Arg Gly Cys Glu Leu 
                85  


<210>  1833
<211>  194
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1833

Xaa Ser Phe Val Gly Ser Asp Pro Ser Gln Phe Cys Gly Gln Gln Gly 
1               5                   10                  15      


Ser Pro Leu Gly Arg Pro Pro Gly Gln Arg Glu Phe Val Ser Ser Gly 
            20                  25                  30          


Arg Ser Leu Arg Leu Thr Phe Arg Thr Gln Pro Ser Ser Glu Asn Lys 
        35                  40                  45              


Thr Ala His Leu His Lys Gly Phe Leu Ala Leu Tyr Gln Thr Val Val 
    50                  55                  60                  


Cys Gly Arg Pro Val Thr Pro Ile Ala Gln Asn Gln Thr Thr Leu Gly 
65                  70                  75                  80  


Ser Ser Arg Ala Lys Leu Gly Asn Phe Pro Trp Gln Ala Phe Thr Ser 
                85                  90                  95      


Ile His Gly Arg Gly Gly Gly Ala Leu Leu Gly Asp Arg Trp Ile Leu 
            100                 105                 110         


Thr Ala Ala His Thr Ile Tyr Pro Lys Asp Ser Val Ser Leu Arg Lys 
        115                 120                 125             


Asn Gln Ser Val Asn Val Phe Leu Gly His Thr Ala Ile Asp Glu Met 
    130                 135                 140                 


Leu Lys Leu Gly Asn His Pro Val His Arg Val Val Val His Pro Asp 
145                 150                 155                 160 


Tyr Arg Gln Asn Glu Ser His Asn Phe Ser Gly Asp Ile Ala Leu Leu 
                165                 170                 175     


Glu Leu Gln His Ser Ile Pro Leu Gly Pro Asn Val Leu Pro Val Cys 
            180                 185                 190         


Leu Pro 
        


<210>  1834
<211>  157
<212>  PRT
<213>  Homo Sapiens

<400>  1834

Met Lys Asn Cys Gly Val Asn Cys Ser Gly Asp Val Phe Thr Ala Leu 
1               5                   10                  15      


Ile Gly Glu Ile Ala Ser Pro Asn Tyr Pro Lys Pro Tyr Pro Glu Asn 
            20                  25                  30          


Ser Arg Cys Glu Tyr Gln Ile Arg Leu Glu Lys Gly Phe Gln Val Val 
        35                  40                  45              


Val Thr Leu Arg Arg Glu Asp Phe Asp Val Glu Ala Ala Asp Ser Ala 
    50                  55                  60                  


Gly Asn Cys Leu Asp Ser Leu Val Phe Val Ala Gly Asp Arg Gln Phe 
65                  70                  75                  80  


Gly Pro Tyr Cys Gly His Gly Phe Pro Gly Pro Leu Asn Ile Glu Thr 
                85                  90                  95      


Lys Ser Asn Ala Leu Asp Ile Ile Phe Gln Thr Asp Leu Thr Gly Gln 
            100                 105                 110         


Lys Lys Gly Trp Lys Leu Arg Tyr His Gly Asp Pro Met Pro Cys Pro 
        115                 120                 125             


Lys Glu Asp Thr Pro Asn Ser Val Trp Glu Pro Ala Lys Ala Lys Tyr 
    130                 135                 140                 


Val Phe Arg Asp Val Val Gln Ile Thr Cys Leu Asp Gly 
145                 150                 155         


<210>  1835
<211>  521
<212>  PRT
<213>  Homo Sapiens

<400>  1835

Met Lys Asn Cys Gly Val Asn Cys Ser Gly Asp Val Phe Thr Ala Leu 
1               5                   10                  15      


Ile Gly Glu Ile Ala Ser Pro Asn Tyr Pro Lys Pro Tyr Pro Glu Asn 
            20                  25                  30          


Ser Arg Cys Glu Tyr Gln Ile Arg Leu Glu Lys Gly Phe Gln Val Val 
        35                  40                  45              


Val Thr Leu Arg Arg Glu Asp Phe Asp Val Glu Ala Ala Asp Ser Ala 
    50                  55                  60                  


Gly Asn Cys Leu Asp Ser Leu Val Phe Val Ala Gly Asp Arg Gln Phe 
65                  70                  75                  80  


Gly Pro Tyr Cys Gly His Gly Phe Pro Gly Pro Leu Asn Ile Glu Thr 
                85                  90                  95      


Lys Ser Asn Ala Leu Asp Ile Ile Phe Gln Thr Asp Leu Thr Gly Gln 
            100                 105                 110         


Lys Lys Gly Trp Lys Leu Arg Tyr His Gly Asp Pro Met Pro Cys Pro 
        115                 120                 125             


Lys Glu Asp Thr Pro Asn Ser Val Trp Glu Pro Ala Lys Ala Lys Tyr 
    130                 135                 140                 


Val Phe Arg Asp Val Val Gln Ile Thr Cys Leu Asp Gly Phe Glu Val 
145                 150                 155                 160 


Val Glu Gly Arg Val Gly Ala Thr Ser Phe Tyr Ser Thr Cys Gln Ser 
                165                 170                 175     


Asn Gly Lys Trp Ser Asn Ser Lys Leu Lys Cys Gln Pro Val Asp Cys 
            180                 185                 190         


Gly Ile Pro Glu Ser Ile Glu Asn Gly Lys Val Glu Asp Pro Glu Ser 
        195                 200                 205             


Thr Leu Phe Gly Ser Val Ile Arg Tyr Thr Cys Glu Glu Pro Tyr Tyr 
    210                 215                 220                 


Tyr Met Glu Asn Gly Gly Gly Gly Glu Tyr His Cys Ala Gly Asn Gly 
225                 230                 235                 240 


Ser Trp Val Asn Glu Val Leu Gly Pro Glu Leu Pro Lys Cys Val Pro 
                245                 250                 255     


Val Cys Gly Val Pro Arg Glu Pro Phe Glu Glu Lys Gln Arg Ile Ile 
            260                 265                 270         


Gly Gly Ser Asp Ala Asp Ile Lys Asn Phe Pro Trp Gln Val Phe Phe 
        275                 280                 285             


Asp Asn Pro Trp Ala Gly Gly Ala Leu Ile Asn Glu Tyr Trp Val Leu 
    290                 295                 300                 


Thr Ala Ala His Val Val Glu Gly Asn Arg Glu Pro Thr Met Tyr Val 
305                 310                 315                 320 


Gly Ser Thr Ser Val Gln Thr Ser Arg Leu Ala Lys Ser Lys Met Leu 
                325                 330                 335     


Thr Pro Glu His Val Phe Ile His Pro Gly Trp Lys Leu Leu Glu Val 
            340                 345                 350         


Pro Glu Gly Arg Thr Asn Phe Asp Asn Asp Ile Ala Leu Val Arg Leu 
        355                 360                 365             


Lys Asp Pro Val Lys Met Gly Pro Thr Val Ser Pro Ile Cys Leu Pro 
    370                 375                 380                 


Gly Thr Ser Ser Asp Tyr Asn Leu Met Asp Gly Asp Leu Gly Leu Ile 
385                 390                 395                 400 


Ser Gly Trp Gly Arg Thr Glu Lys Arg Asp Arg Ala Val Arg Leu Lys 
                405                 410                 415     


Ala Ala Arg Leu Pro Val Ala Pro Leu Arg Lys Cys Lys Glu Val Lys 
            420                 425                 430         


Val Glu Lys Pro Thr Ala Asp Ala Glu Ala Tyr Val Phe Thr Pro Asn 
        435                 440                 445             


Met Ile Cys Ala Gly Gly Glu Lys Gly Met Asp Ser Cys Lys Gly Asp 
    450                 455                 460                 


Ser Gly Gly Ala Phe Ala Val Gln Asp Pro Asn Asp Lys Thr Lys Phe 
465                 470                 475                 480 


Tyr Ala Ala Gly Leu Val Ser Trp Gly Pro Gln Cys Gly Thr Tyr Gly 
                485                 490                 495     


Leu Tyr Thr Arg Val Lys Asn Tyr Val Asp Trp Ile Met Lys Thr Met 
            500                 505                 510         


Gln Glu Asn Ser Thr Pro Arg Glu Asp 
        515                 520     


<210>  1836
<211>  101
<212>  PRT
<213>  Homo Sapiens

<400>  1836

Met Trp Cys Ile Val Leu Phe Ser Leu Leu Ala Trp Val Tyr Ala Glu 
1               5                   10                  15      


Pro Thr Met Tyr Gly Glu Ile Leu Ser Pro Asn Tyr Pro Gln Ala Tyr 
            20                  25                  30          


Pro Ser Glu Val Glu Lys Ser Trp Asp Ile Glu Val Pro Glu Gly Tyr 
        35                  40                  45              


Gly Ile His Leu Tyr Phe Thr His Leu Asp Ile Glu Leu Ser Glu Asn 
    50                  55                  60                  


Cys Ala Tyr Asp Ser Val Gln Ile Ile Ser Gly Asp Thr Glu Glu Gly 
65                  70                  75                  80  


Arg Leu Cys Gly Gln Arg Ser Ser Asn Asn Pro His Ser Pro Ile Val 
                85                  90                  95      


Glu Glu Phe Gln Val 
            100     


<210>  1837
<211>  103
<212>  PRT
<213>  Homo Sapiens

<400>  1837

Met Trp Cys Ile Val Leu Phe Ser Leu Leu Ala Trp Val Tyr Ala Glu 
1               5                   10                  15      


Pro Thr Met Tyr Gly Glu Ile Leu Ser Pro Asn Tyr Pro Gln Ala Tyr 
            20                  25                  30          


Pro Ser Glu Val Glu Lys Ser Trp Asp Ile Glu Val Pro Glu Gly Tyr 
        35                  40                  45              


Gly Ile His Leu Tyr Phe Thr His Leu Asp Ile Glu Leu Ser Glu Asn 
    50                  55                  60                  


Cys Ala Tyr Asp Ser Val Gln Ile Ile Ser Gly Asp Thr Glu Glu Gly 
65                  70                  75                  80  


Arg Leu Cys Gly Gln Arg Ser Ser Asn Asn Pro His Ser Pro Ile Val 
                85                  90                  95      


Glu Glu Phe Gln Val Pro Tyr 
            100             


<210>  1838
<211>  168
<212>  PRT
<213>  Homo Sapiens

<400>  1838

Met Trp Cys Ile Val Leu Phe Ser Leu Leu Ala Trp Val Tyr Ala Glu 
1               5                   10                  15      


Pro Thr Met Tyr Gly Glu Ile Leu Ser Pro Asn Tyr Pro Gln Ala Tyr 
            20                  25                  30          


Pro Ser Glu Val Glu Lys Ser Trp Asp Ile Glu Val Pro Glu Gly Tyr 
        35                  40                  45              


Gly Ile His Leu Tyr Phe Thr His Leu Asp Ile Glu Leu Ser Glu Asn 
    50                  55                  60                  


Cys Ala Tyr Asp Ser Val Gln Ile Ile Ser Gly Asp Thr Glu Glu Gly 
65                  70                  75                  80  


Arg Leu Cys Gly Gln Arg Ser Ser Asn Asn Pro His Ser Pro Ile Val 
                85                  90                  95      


Glu Glu Phe Gln Val Pro Tyr Asn Lys Leu Gln Val Ile Phe Lys Ser 
            100                 105                 110         


Asp Phe Ser Asn Glu Glu Arg Phe Thr Gly Phe Ala Ala Tyr Tyr Val 
        115                 120                 125             


Ala Thr Asp Ile Asn Glu Cys Thr Asp Phe Val Asp Val Pro Cys Ser 
    130                 135                 140                 


His Phe Cys Asn Asn Phe Ile Gly Gly Tyr Phe Cys Ser Cys Pro Pro 
145                 150                 155                 160 


Glu Tyr Phe Leu His Asp Asp Met 
                165             


<210>  1839
<211>  688
<212>  PRT
<213>  Homo Sapiens

<400>  1839

Met Trp Cys Ile Val Leu Phe Ser Leu Leu Ala Trp Val Tyr Ala Glu 
1               5                   10                  15      


Pro Thr Met Tyr Gly Glu Ile Leu Ser Pro Asn Tyr Pro Gln Ala Tyr 
            20                  25                  30          


Pro Ser Glu Val Glu Lys Ser Trp Asp Ile Glu Val Pro Glu Gly Tyr 
        35                  40                  45              


Gly Ile His Leu Tyr Phe Thr His Leu Asp Ile Glu Leu Ser Glu Asn 
    50                  55                  60                  


Cys Ala Tyr Asp Ser Val Gln Ile Ile Ser Gly Asp Thr Glu Glu Gly 
65                  70                  75                  80  


Arg Leu Cys Gly Gln Arg Ser Ser Asn Asn Pro His Ser Pro Ile Val 
                85                  90                  95      


Glu Glu Phe Gln Val Pro Tyr Asn Lys Leu Gln Val Ile Phe Lys Ser 
            100                 105                 110         


Asp Phe Ser Asn Glu Glu Arg Phe Thr Gly Phe Ala Ala Tyr Tyr Val 
        115                 120                 125             


Ala Thr Asp Ile Asn Glu Cys Thr Asp Phe Val Asp Val Pro Cys Ser 
    130                 135                 140                 


His Phe Cys Asn Asn Phe Ile Gly Gly Tyr Phe Cys Ser Cys Pro Pro 
145                 150                 155                 160 


Glu Tyr Phe Leu His Asp Asp Met Lys Asn Cys Gly Val Asn Cys Ser 
                165                 170                 175     


Gly Asp Val Phe Thr Ala Leu Ile Gly Glu Ile Ala Ser Pro Asn Tyr 
            180                 185                 190         


Pro Lys Pro Tyr Pro Glu Asn Ser Arg Cys Glu Tyr Gln Ile Arg Leu 
        195                 200                 205             


Glu Lys Gly Phe Gln Val Val Val Thr Leu Arg Arg Glu Asp Phe Asp 
    210                 215                 220                 


Val Glu Ala Ala Asp Ser Ala Gly Asn Cys Leu Asp Ser Leu Val Phe 
225                 230                 235                 240 


Val Ala Gly Asp Arg Gln Phe Gly Pro Tyr Cys Gly His Gly Phe Pro 
                245                 250                 255     


Gly Pro Leu Asn Ile Glu Thr Lys Ser Asn Ala Leu Asp Ile Ile Phe 
            260                 265                 270         


Gln Thr Asp Leu Thr Gly Gln Lys Lys Gly Trp Lys Leu Arg Tyr His 
        275                 280                 285             


Gly Asp Pro Met Pro Cys Pro Lys Glu Asp Thr Pro Asn Ser Val Trp 
    290                 295                 300                 


Glu Pro Ala Lys Ala Lys Tyr Val Phe Arg Asp Val Val Gln Ile Thr 
305                 310                 315                 320 


Cys Leu Asp Gly Phe Glu Val Val Glu Gly Arg Val Gly Ala Thr Ser 
                325                 330                 335     


Phe Tyr Ser Thr Cys Gln Ser Asn Gly Lys Trp Ser Asn Ser Lys Leu 
            340                 345                 350         


Lys Cys Gln Pro Val Asp Cys Gly Ile Pro Glu Ser Ile Glu Asn Gly 
        355                 360                 365             


Lys Val Glu Asp Pro Glu Ser Thr Leu Phe Gly Ser Val Ile Arg Tyr 
    370                 375                 380                 


Thr Cys Glu Glu Pro Tyr Tyr Tyr Met Glu Asn Gly Gly Gly Gly Glu 
385                 390                 395                 400 


Tyr His Cys Ala Gly Asn Gly Ser Trp Val Asn Glu Val Leu Gly Pro 
                405                 410                 415     


Glu Leu Pro Lys Cys Val Pro Val Cys Gly Val Pro Arg Glu Pro Phe 
            420                 425                 430         


Glu Glu Lys Gln Arg Ile Ile Gly Gly Ser Asp Ala Asp Ile Lys Asn 
        435                 440                 445             


Phe Pro Trp Gln Val Phe Phe Asp Asn Pro Trp Ala Gly Gly Ala Leu 
    450                 455                 460                 


Ile Asn Glu Tyr Trp Val Leu Thr Ala Ala His Val Val Glu Gly Asn 
465                 470                 475                 480 


Arg Glu Pro Thr Met Tyr Val Gly Ser Thr Ser Val Gln Thr Ser Arg 
                485                 490                 495     


Leu Ala Lys Ser Lys Met Leu Thr Pro Glu His Val Phe Ile His Pro 
            500                 505                 510         


Gly Trp Lys Leu Leu Glu Val Pro Glu Gly Arg Thr Asn Phe Asp Asn 
        515                 520                 525             


Asp Ile Ala Leu Val Arg Leu Lys Asp Pro Val Lys Met Gly Pro Thr 
    530                 535                 540                 


Val Ser Pro Ile Cys Leu Pro Gly Thr Ser Ser Asp Tyr Asn Leu Met 
545                 550                 555                 560 


Asp Gly Asp Leu Gly Leu Ile Ser Gly Trp Gly Arg Thr Glu Lys Arg 
                565                 570                 575     


Asp Arg Ala Val Arg Leu Lys Ala Ala Arg Leu Pro Val Ala Pro Leu 
            580                 585                 590         


Arg Lys Cys Lys Glu Val Lys Val Glu Lys Pro Thr Ala Asp Ala Glu 
        595                 600                 605             


Ala Tyr Val Phe Thr Pro Asn Met Ile Cys Ala Gly Gly Glu Lys Gly 
    610                 615                 620                 


Met Asp Ser Cys Lys Gly Asp Ser Gly Gly Ala Phe Ala Val Gln Asp 
625                 630                 635                 640 


Pro Asn Asp Lys Thr Lys Phe Tyr Ala Ala Gly Leu Val Ser Trp Gly 
                645                 650                 655     


Pro Gln Cys Gly Thr Tyr Gly Leu Tyr Thr Arg Val Lys Asn Tyr Val 
            660                 665                 670         


Asp Trp Ile Met Lys Thr Met Gln Glu Asn Ser Thr Pro Arg Glu Asp 
        675                 680                 685             


<210>  1840
<211>  688
<212>  PRT
<213>  Homo Sapiens

<400>  1840

Met Trp Cys Ile Val Leu Phe Ser Leu Leu Ala Trp Val Tyr Ala Glu 
1               5                   10                  15      


Pro Thr Met Tyr Gly Glu Ile Leu Ser Pro Asn Tyr Pro Gln Ala Tyr 
            20                  25                  30          


Pro Ser Glu Val Glu Lys Ser Trp Asp Ile Glu Val Pro Glu Gly Tyr 
        35                  40                  45              


Gly Ile His Leu Tyr Phe Thr His Leu Asp Ile Glu Leu Ser Glu Asn 
    50                  55                  60                  


Cys Ala Tyr Asp Ser Val Gln Ile Ile Ser Gly Asp Thr Glu Glu Gly 
65                  70                  75                  80  


Arg Leu Cys Gly Gln Arg Ser Ser Asn Asn Pro His Ser Pro Ile Val 
                85                  90                  95      


Glu Glu Phe Gln Val Pro Tyr Asn Lys Leu Gln Val Ile Phe Lys Ser 
            100                 105                 110         


Asp Phe Ser Asn Glu Glu Arg Phe Thr Gly Phe Ala Ala Tyr Tyr Val 
        115                 120                 125             


Ala Thr Asp Ile Asn Glu Cys Thr Asp Phe Val Asp Val Pro Cys Ser 
    130                 135                 140                 


His Phe Cys Asn Asn Phe Ile Gly Gly Tyr Phe Cys Ser Cys Pro Pro 
145                 150                 155                 160 


Glu Tyr Phe Leu His Asp Asp Met Lys Asn Cys Gly Val Asn Cys Ser 
                165                 170                 175     


Gly Asp Val Phe Thr Ala Leu Ile Gly Glu Ile Ala Ser Pro Asn Tyr 
            180                 185                 190         


Pro Lys Pro Tyr Pro Glu Asn Ser Arg Cys Glu Tyr Gln Ile Arg Leu 
        195                 200                 205             


Glu Lys Gly Phe Gln Val Val Val Thr Leu Arg Arg Glu Asp Phe Asp 
    210                 215                 220                 


Val Glu Ala Ala Asp Ser Ala Gly Asn Cys Leu Asp Ser Leu Val Phe 
225                 230                 235                 240 


Val Ala Gly Asp Arg Gln Phe Gly Pro Tyr Cys Gly His Gly Phe Pro 
                245                 250                 255     


Gly Pro Leu Asn Ile Glu Thr Lys Ser Asn Ala Leu Asp Ile Ile Phe 
            260                 265                 270         


Gln Thr Asp Leu Thr Gly Gln Lys Lys Gly Trp Lys Leu Arg Tyr His 
        275                 280                 285             


Gly Asp Pro Met Pro Cys Pro Lys Glu Asp Thr Pro Asn Ser Val Trp 
    290                 295                 300                 


Glu Pro Ala Lys Ala Lys Tyr Val Phe Arg Asp Val Val Gln Ile Thr 
305                 310                 315                 320 


Cys Leu Asp Gly Phe Glu Val Val Glu Gly Arg Val Gly Ala Thr Ser 
                325                 330                 335     


Phe Tyr Ser Thr Cys Gln Ser Asn Gly Lys Trp Ser Asn Ser Lys Leu 
            340                 345                 350         


Lys Cys Gln Pro Val Asp Cys Gly Ile Pro Glu Ser Ile Glu Asn Gly 
        355                 360                 365             


Lys Val Glu Asp Pro Glu Ser Thr Leu Phe Gly Ser Val Ile Arg Tyr 
    370                 375                 380                 


Thr Cys Glu Glu Pro Tyr Tyr Tyr Met Glu Asn Gly Gly Gly Gly Glu 
385                 390                 395                 400 


Tyr His Cys Ala Gly Asn Gly Ser Trp Val Asn Glu Val Leu Gly Pro 
                405                 410                 415     


Glu Leu Pro Lys Cys Val Pro Val Cys Gly Val Pro Arg Glu Pro Phe 
            420                 425                 430         


Glu Glu Lys Gln Arg Ile Ile Gly Gly Ser Asp Ala Asp Ile Lys Asn 
        435                 440                 445             


Phe Pro Trp Gln Val Phe Phe Asp Asn Pro Trp Ala Gly Gly Ala Leu 
    450                 455                 460                 


Ile Asn Glu Tyr Trp Val Leu Thr Ala Ala His Val Val Glu Gly Asn 
465                 470                 475                 480 


Arg Glu Pro Thr Met Tyr Val Gly Ser Thr Ser Val Gln Thr Ser Arg 
                485                 490                 495     


Leu Ala Lys Ser Lys Met Leu Thr Pro Glu His Val Phe Ile His Pro 
            500                 505                 510         


Gly Trp Lys Leu Leu Glu Val Pro Glu Gly Arg Thr Asn Phe Asp Asn 
        515                 520                 525             


Asp Ile Ala Leu Val Arg Leu Lys Asp Pro Val Lys Met Gly Pro Thr 
    530                 535                 540                 


Val Ser Pro Ile Cys Leu Pro Gly Thr Ser Ser Asp Tyr Asn Leu Met 
545                 550                 555                 560 


Asp Gly Asp Leu Gly Leu Ile Ser Gly Trp Gly Arg Thr Glu Lys Arg 
                565                 570                 575     


Asp Arg Ala Val Arg Leu Lys Ala Ala Arg Leu Pro Val Ala Pro Leu 
            580                 585                 590         


Arg Lys Cys Lys Glu Val Lys Val Glu Lys Pro Thr Ala Asp Ala Glu 
        595                 600                 605             


Ala Tyr Val Phe Thr Pro Asn Met Ile Cys Ala Gly Gly Glu Lys Gly 
    610                 615                 620                 


Met Asp Ser Cys Lys Gly Asp Ser Gly Gly Ala Phe Ala Val Gln Asp 
625                 630                 635                 640 


Pro Asn Asp Lys Thr Lys Phe Tyr Ala Ala Gly Leu Val Ser Trp Gly 
                645                 650                 655     


Pro Gln Cys Gly Thr Tyr Gly Leu Tyr Thr Arg Val Lys Asn Tyr Val 
            660                 665                 670         


Asp Trp Ile Met Lys Thr Met Gln Glu Asn Ser Thr Pro Arg Glu Asp 
        675                 680                 685             


<210>  1841
<211>  688
<212>  PRT
<213>  Homo Sapiens

<400>  1841

Met Trp Cys Ile Val Leu Phe Ser Leu Leu Ala Trp Val Tyr Ala Glu 
1               5                   10                  15      


Pro Thr Met Tyr Gly Glu Ile Leu Ser Pro Asn Tyr Pro Gln Ala Tyr 
            20                  25                  30          


Pro Ser Glu Val Glu Lys Ser Trp Asp Ile Glu Val Pro Glu Gly Tyr 
        35                  40                  45              


Gly Ile His Leu Tyr Phe Thr His Leu Asp Ile Glu Leu Ser Glu Asn 
    50                  55                  60                  


Cys Ala Tyr Asp Ser Val Gln Ile Ile Ser Gly Asp Thr Glu Glu Gly 
65                  70                  75                  80  


Arg Leu Cys Gly Gln Arg Ser Ser Asn Asn Pro His Ser Pro Ile Val 
                85                  90                  95      


Glu Glu Phe Gln Val Pro Tyr Asn Lys Leu Gln Val Ile Phe Lys Ser 
            100                 105                 110         


Asp Phe Ser Asn Glu Glu Arg Phe Thr Gly Phe Ala Ala Tyr Tyr Val 
        115                 120                 125             


Ala Thr Asp Ile Asn Glu Cys Thr Asp Phe Val Asp Val Pro Cys Ser 
    130                 135                 140                 


His Phe Cys Asn Asn Phe Ile Gly Gly Tyr Phe Cys Ser Cys Pro Pro 
145                 150                 155                 160 


Glu Tyr Phe Leu His Asp Asp Met Lys Asn Cys Gly Val Asn Cys Ser 
                165                 170                 175     


Gly Asp Val Phe Thr Ala Leu Ile Gly Glu Ile Ala Ser Pro Asn Tyr 
            180                 185                 190         


Pro Lys Pro Tyr Pro Glu Asn Ser Arg Cys Glu Tyr Gln Ile Arg Leu 
        195                 200                 205             


Glu Lys Gly Phe Gln Val Val Val Thr Leu Arg Arg Glu Asp Phe Asp 
    210                 215                 220                 


Val Glu Ala Ala Asp Ser Ala Gly Asn Cys Leu Asp Ser Leu Val Phe 
225                 230                 235                 240 


Val Ala Gly Asp Arg Gln Phe Gly Pro Tyr Cys Gly His Gly Phe Pro 
                245                 250                 255     


Gly Pro Leu Asn Ile Glu Thr Lys Ser Asn Ala Leu Asp Ile Ile Phe 
            260                 265                 270         


Gln Thr Asp Leu Thr Gly Gln Lys Lys Gly Trp Lys Leu Arg Tyr His 
        275                 280                 285             


Gly Asp Pro Met Pro Cys Pro Lys Glu Asp Thr Pro Asn Ser Val Trp 
    290                 295                 300                 


Glu Pro Ala Lys Ala Lys Tyr Val Phe Arg Asp Val Val Gln Ile Thr 
305                 310                 315                 320 


Cys Leu Asp Gly Phe Glu Val Val Glu Gly Arg Val Gly Ala Thr Ser 
                325                 330                 335     


Phe Tyr Ser Thr Cys Gln Ser Asn Gly Lys Trp Ser Asn Ser Lys Leu 
            340                 345                 350         


Lys Cys Gln Pro Val Asp Cys Gly Ile Pro Glu Ser Ile Glu Asn Gly 
        355                 360                 365             


Lys Val Glu Asp Pro Glu Ser Thr Leu Phe Gly Ser Val Ile Arg Tyr 
    370                 375                 380                 


Thr Cys Glu Glu Pro Tyr Tyr Tyr Met Glu Asn Gly Gly Gly Gly Glu 
385                 390                 395                 400 


Tyr His Cys Ala Gly Asn Gly Ser Trp Val Asn Glu Val Leu Gly Pro 
                405                 410                 415     


Glu Leu Pro Lys Cys Val Pro Val Cys Gly Val Pro Arg Glu Pro Phe 
            420                 425                 430         


Glu Glu Lys Gln Arg Ile Ile Gly Gly Ser Asp Ala Asp Ile Lys Asn 
        435                 440                 445             


Phe Pro Trp Gln Val Phe Phe Asp Asn Pro Trp Ala Gly Gly Ala Leu 
    450                 455                 460                 


Ile Asn Glu Tyr Trp Val Leu Thr Ala Ala His Val Val Glu Gly Asn 
465                 470                 475                 480 


Arg Glu Pro Thr Met Tyr Val Gly Ser Thr Ser Val Gln Thr Ser Arg 
                485                 490                 495     


Leu Ala Lys Ser Lys Met Leu Thr Pro Glu His Val Phe Ile His Pro 
            500                 505                 510         


Gly Trp Lys Leu Leu Glu Val Pro Glu Gly Arg Thr Asn Phe Asp Asn 
        515                 520                 525             


Asp Ile Ala Leu Val Arg Leu Lys Asp Pro Val Lys Met Gly Pro Thr 
    530                 535                 540                 


Val Ser Pro Ile Cys Leu Pro Gly Thr Ser Ser Asp Tyr Asn Leu Met 
545                 550                 555                 560 


Asp Gly Asp Leu Gly Leu Ile Ser Gly Trp Gly Arg Thr Glu Lys Arg 
                565                 570                 575     


Asp Arg Ala Val Arg Leu Lys Ala Ala Arg Leu Pro Val Ala Pro Leu 
            580                 585                 590         


Arg Lys Cys Lys Glu Val Lys Val Glu Lys Pro Thr Ala Asp Ala Glu 
        595                 600                 605             


Ala Tyr Val Phe Thr Pro Asn Met Ile Cys Ala Gly Gly Glu Lys Gly 
    610                 615                 620                 


Met Asp Ser Cys Lys Gly Asp Ser Gly Gly Ala Phe Ala Val Gln Asp 
625                 630                 635                 640 


Pro Asn Asp Lys Thr Lys Phe Tyr Ala Ala Gly Leu Val Ser Trp Gly 
                645                 650                 655     


Pro Gln Cys Gly Thr Tyr Gly Leu Tyr Thr Arg Val Lys Asn Tyr Val 
            660                 665                 670         


Asp Trp Ile Met Lys Thr Met Gln Glu Asn Ser Thr Pro Arg Glu Asp 
        675                 680                 685             


<210>  1842
<211>  682
<212>  PRT
<213>  Homo Sapiens

<400>  1842

Met Tyr Gly Glu Ile Leu Ser Pro Asn Tyr Pro Gln Ala Tyr Pro Ser 
1               5                   10                  15      


Glu Val Glu Lys Ser Trp Asp Ile Glu Val Pro Glu Gly Tyr Gly Ile 
            20                  25                  30          


His Leu Tyr Phe Thr His Leu Asp Ile Glu Leu Ser Glu Asn Cys Ala 
        35                  40                  45              


Tyr Asp Ser Val Gln Ile Ile Ser Gly Asp Thr Glu Glu Gly Arg Leu 
    50                  55                  60                  


Cys Gly Gln Arg Ser Ser Asn Asn Pro His Ser Pro Ile Val Glu Glu 
65                  70                  75                  80  


Phe Gln Val Pro Tyr Asn Lys Leu Gln Val Ile Phe Lys Ser Asp Phe 
                85                  90                  95      


Ser Asn Glu Glu Arg Phe Thr Gly Phe Ala Ala Tyr Tyr Val Ala Thr 
            100                 105                 110         


Asp Lys Asp Glu Cys Ser Gly Arg Ala Gln Leu Trp Asn His Met Ser 
        115                 120                 125             


Asp Val Pro Cys Ser His Phe Cys Asn Asn Phe Ile Gly Gly Tyr Phe 
    130                 135                 140                 


Cys Ser Cys Pro Pro Glu Tyr Phe Leu His Asp Asp Met Lys Asn Cys 
145                 150                 155                 160 


Gly Val Asn Cys Ser Gly Asp Val Phe Thr Ala Leu Ile Gly Glu Ile 
                165                 170                 175     


Ala Ser Pro Asn Tyr Pro Lys Pro Tyr Pro Glu Asn Ser Arg Cys Glu 
            180                 185                 190         


Tyr Gln Ile Arg Leu Glu Lys Gly Phe Gln Val His Leu Ser Leu Leu 
        195                 200                 205             


Leu Lys Leu Glu Cys Ser Gly Ala Ile Thr Ala His Cys Ser Leu Asp 
    210                 215                 220                 


Leu Leu Gly Ser Ile Ala Gly Asp Arg Gln Phe Gly Pro Tyr Cys Gly 
225                 230                 235                 240 


His Gly Phe Pro Gly Pro Leu Asn Ile Glu Thr Lys Ser Asn Ala Leu 
                245                 250                 255     


Asp Ile Ile Phe Gln Thr Asp Leu Thr Gly Gln Lys Lys Gly Trp Lys 
            260                 265                 270         


Leu Arg Tyr His Gly Asp Pro Met Pro Cys Pro Lys Glu Asp Thr Pro 
        275                 280                 285             


Asn Ser Val Trp Glu Pro Ala Lys Ala Lys Tyr Val Phe Arg Asp Val 
    290                 295                 300                 


Val Gln Ile Thr Cys Leu Asp Gly Phe Glu Val Val Glu Gly Arg Val 
305                 310                 315                 320 


Gly Ala Thr Ser Phe Tyr Ser Thr Cys Gln Ser Asn Gly Lys Trp Ser 
                325                 330                 335     


Asn Ser Lys Leu Lys Cys Gln Pro Val Asp Cys Gly Ile Pro Glu Ser 
            340                 345                 350         


Ile Glu Asn Gly Lys Val Glu Asp Pro Glu Ser Thr Leu Phe Gly Ser 
        355                 360                 365             


Val Ile Arg Tyr Thr Cys Glu Glu Pro Tyr Tyr Tyr Met Glu Asn Gly 
    370                 375                 380                 


Gly Gly Gly Glu Glu Arg Glu Arg Gly Glu Tyr His Cys Ala Gly Asn 
385                 390                 395                 400 


Gly Ser Trp Val Asn Glu Val Leu Gly Pro Glu Leu Pro Lys Cys Val 
                405                 410                 415     


Pro Val Cys Gly Val Pro Arg Glu Pro Phe Glu Glu Lys Gln Arg Ile 
            420                 425                 430         


Ile Gly Gly Ser Asp Ala Asp Ile Lys Asn Phe Pro Trp Gln Val Phe 
        435                 440                 445             


Phe Asp Asn Pro Trp Ala Gly Gly Ala Leu Ile Asn Glu Tyr Trp Val 
    450                 455                 460                 


Leu Thr Ala Ala His Val Val Glu Gly Asn Arg Glu Pro Thr Met Tyr 
465                 470                 475                 480 


Val Gly Ser Thr Ser Val Gln Thr Ser Arg Leu Ala Lys Ser Lys Met 
                485                 490                 495     


Leu Thr Pro Glu His Val Phe Ile His Pro Gly Trp Lys Leu Leu Glu 
            500                 505                 510         


Val Pro Glu Gly Arg Thr Asn Phe Asp Asn Asp Ile Ala Leu Val Arg 
        515                 520                 525             


Leu Lys Asp Pro Val Lys Met Gly Pro Thr Val Ser Pro Ile Cys Leu 
    530                 535                 540                 


Pro Gly Thr Ser Ser Asp Tyr Asn Leu Met Asp Gly Asp Leu Gly Leu 
545                 550                 555                 560 


Ile Ser Gly Trp Gly Arg Thr Glu Lys Arg Asp Arg Ala Val Arg Leu 
                565                 570                 575     


Lys Ala Ala Arg Leu Pro Val Ala Pro Leu Arg Lys Cys Lys Glu Val 
            580                 585                 590         


Lys Val Glu Lys Pro Thr Ala Asp Ala Glu Ala Tyr Val Phe Thr Pro 
        595                 600                 605             


Asn Met Ile Cys Ala Gly Gly Glu Lys Gly Met Asp Ser Cys Lys Gly 
    610                 615                 620                 


Asp Ser Gly Gly Ala Phe Ala Val Gln Asp Pro Asn Asp Lys Thr Lys 
625                 630                 635                 640 


Phe Tyr Ala Ala Gly Leu Val Ser Trp Gly Pro Gln Cys Gly Thr Tyr 
                645                 650                 655     


Gly Leu Tyr Thr Arg Val Lys Asn Tyr Val Asp Trp Ile Met Lys Thr 
            660                 665                 670         


Met Gln Glu Asn Ser Thr Pro Arg Glu Asp 
        675                 680         


<210>  1843
<211>  355
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1843

Xaa Ser Lys Val Arg Arg Cys Arg Lys Pro Gly Pro Arg Asp Arg Gln 
1               5                   10                  15      


Leu Thr Arg Val Asp Lys Ser Pro Glu Met Trp Cys Ile Val Leu Phe 
            20                  25                  30          


Ser Leu Leu Ala Trp Val Tyr Ala Glu Pro Thr Met Tyr Gly Glu Ile 
        35                  40                  45              


Leu Ser Pro Asn Tyr Pro Gln Ala Tyr Pro Ser Glu Val Glu Lys Ser 
    50                  55                  60                  


Trp Asp Ile Glu Val Pro Glu Gly Tyr Gly Ile His Leu Tyr Phe Thr 
65                  70                  75                  80  


His Leu Asp Ile Glu Leu Ser Glu Asn Cys Ala Tyr Asp Ser Val Gln 
                85                  90                  95      


Ile Ile Ser Gly Asp Thr Glu Glu Gly Arg Leu Cys Gly Gln Arg Ser 
            100                 105                 110         


Ser Asn Asn Pro His Ser Pro Ile Val Glu Glu Phe Gln Val Pro Tyr 
        115                 120                 125             


Asn Lys Leu Gln Val Ile Phe Lys Ser Asp Phe Ser Asn Glu Glu Arg 
    130                 135                 140                 


Phe Thr Gly Phe Ala Ala Tyr Tyr Val Ala Thr Asp Ile Asn Glu Cys 
145                 150                 155                 160 


Thr Asp Phe Val Asp Val Pro Cys Ser His Phe Cys Asn Asn Phe Ile 
                165                 170                 175     


Gly Gly Tyr Phe Cys Ser Cys Pro Pro Glu Tyr Phe Leu His Asp Asp 
            180                 185                 190         


Met Lys Asn Cys Gly Val Asn Cys Ser Gly Asp Val Phe Thr Ala Leu 
        195                 200                 205             


Ile Gly Glu Ile Ala Ser Pro Asn Tyr Pro Lys Pro Tyr Pro Glu Asn 
    210                 215                 220                 


Ser Arg Cys Glu Tyr Gln Ile Arg Leu Glu Lys Gly Phe Gln Val Val 
225                 230                 235                 240 


Val Thr Leu Arg Arg Glu Asp Phe Asp Val Glu Ala Ala Asp Ser Ala 
                245                 250                 255     


Gly Asn Cys Leu Asp Ser Leu Val Phe Val Ala Gly Asp Arg Gln Phe 
            260                 265                 270         


Gly Pro Tyr Cys Gly His Gly Phe Pro Gly Pro Leu Asn Ile Glu Thr 
        275                 280                 285             


Lys Ser Asn Ala Leu Asp Ile Ile Phe Gln Thr Asp Leu Thr Gly Gln 
    290                 295                 300                 


Lys Lys Gly Trp Lys Leu Arg Tyr His Gly Asp Pro Met Pro Cys Pro 
305                 310                 315                 320 


Lys Glu Asp Thr Pro Asn Ser Val Trp Glu Pro Ala Lys Ala Lys Tyr 
                325                 330                 335     


Val Phe Arg Asp Val Val Gln Ile Thr Cys Leu Asp Gly Phe Glu Val 
            340                 345                 350         


Val Glu Lys 
        355 


<210>  1844
<211>  620
<212>  PRT
<213>  Homo Sapiens

<400>  1844

Met Gly Pro Leu Met Val Leu Phe Cys Leu Leu Phe Leu Tyr Pro Ala 
1               5                   10                  15      


Gly His Cys Pro Asn Pro Gly Ile Ser Leu Gly Ala Val Arg Thr Gly 
            20                  25                  30          


Phe Arg Phe Gly His Gly Asp Lys Val Arg Tyr Arg Cys Ser Ser Asn 
        35                  40                  45              


Leu Val Leu Thr Gly Ser Ser Glu Arg Glu Cys Gln Gly Asn Gly Val 
    50                  55                  60                  


Trp Ser Gly Thr Glu Pro Ile Cys Arg Gln Pro Tyr Ser Tyr Asp Phe 
65                  70                  75                  80  


Pro Glu Asp Val Ala Pro Ala Leu Gly Thr Ser Phe Ser His Met Leu 
                85                  90                  95      


Gly Ala Thr Asn Pro Thr Gln Lys Thr Lys Glu Ser Leu Gly Arg Lys 
            100                 105                 110         


Ile Gln Ile Gln Arg Ser Gly His Leu Asn Leu Tyr Leu Leu Leu Asp 
        115                 120                 125             


Cys Ser Gln Ser Val Ser Glu Asn Asp Phe Leu Ile Phe Lys Glu Ser 
    130                 135                 140                 


Ala Ser Leu Met Val Asp Arg Ile Phe Ser Phe Glu Ile Asn Val Ser 
145                 150                 155                 160 


Val Ala Ile Ile Thr Phe Ala Ser Glu Pro Lys Val Leu Met Ser Val 
                165                 170                 175     


Leu Asn Asp Asn Ser Arg Asp Met Thr Glu Val Ile Ser Ser Leu Glu 
            180                 185                 190         


Asn Ala Asn Tyr Lys Asp His Glu Asn Gly Thr Gly Thr Asn Thr Tyr 
        195                 200                 205             


Ala Ala Leu Asn Ser Val Tyr Leu Met Met Asn Asn Gln Met Arg Leu 
    210                 215                 220                 


Leu Gly Met Glu Thr Met Ala Trp Gln Glu Ile Arg His Ala Ile Ile 
225                 230                 235                 240 


Leu Leu Thr Asp Gly Lys Ser Asn Met Gly Gly Ser Pro Lys Thr Ala 
                245                 250                 255     


Val Asp His Ile Arg Glu Ile Leu Asn Ile Asn Gln Lys Arg Asn Asp 
            260                 265                 270         


Tyr Leu Asp Ile Tyr Ala Ile Gly Val Gly Lys Leu Asp Val Asp Trp 
        275                 280                 285             


Arg Glu Leu Asn Glu Leu Gly Ser Lys Lys Asp Gly Glu Arg His Ala 
    290                 295                 300                 


Phe Ile Leu Gln Asp Thr Lys Ala Leu His Gln Val Phe Glu His Met 
305                 310                 315                 320 


Leu Asp Val Ser Lys Leu Thr Asp Thr Ile Cys Gly Val Gly Asn Met 
                325                 330                 335     


Ser Ala Asn Ala Ser Asp Gln Glu Arg Thr Pro Trp His Val Thr Ile 
            340                 345                 350         


Lys Pro Lys Ser Gln Glu Thr Cys Arg Gly Ala Leu Ile Ser Asp Gln 
        355                 360                 365             


Trp Val Leu Thr Ala Ala His Cys Phe Arg Asp Gly Asn Asp His Ser 
    370                 375                 380                 


Leu Trp Arg Val Asn Val Gly Asp Pro Lys Ser Gln Trp Gly Lys Glu 
385                 390                 395                 400 


Phe Leu Ile Glu Lys Ala Val Ile Ser Pro Gly Phe Asp Val Phe Ala 
                405                 410                 415     


Lys Lys Asn Gln Gly Ile Leu Glu Phe Tyr Gly Asp Asp Ile Ala Leu 
            420                 425                 430         


Leu Lys Leu Ala Gln Lys Val Lys Met Ser Thr His Ala Arg Pro Ile 
        435                 440                 445             


Cys Leu Pro Cys Thr Met Glu Ala Asn Leu Ala Leu Arg Arg Pro Gln 
    450                 455                 460                 


Gly Ser Thr Cys Arg Asp His Glu Asn Glu Leu Leu Asn Lys Gln Ser 
465                 470                 475                 480 


Val Pro Ala His Phe Val Ala Leu Asn Gly Ser Lys Leu Asn Ile Asn 
                485                 490                 495     


Leu Lys Met Gly Val Glu Trp Thr Ser Cys Ala Glu Val Val Ser Gln 
            500                 505                 510         


Glu Lys Thr Met Phe Pro Asn Leu Thr Asp Val Arg Glu Val Val Thr 
        515                 520                 525             


Asp Gln Phe Leu Cys Ser Gly Thr Gln Glu Asp Glu Ser Pro Cys Lys 
    530                 535                 540                 


Gly Glu Ser Gly Gly Ala Val Phe Leu Glu Arg Arg Phe Arg Phe Phe 
545                 550                 555                 560 


Gln Val Gly Leu Val Ser Trp Gly Leu Tyr Asn Pro Cys Leu Gly Ser 
                565                 570                 575     


Ala Asp Lys Asn Ser Arg Lys Arg Ala Pro Arg Ser Lys Val Pro Pro 
            580                 585                 590         


Pro Arg Asp Phe His Ile Asn Leu Phe Arg Met Gln Pro Trp Leu Arg 
        595                 600                 605             


Gln His Leu Gly Asp Val Leu Asn Phe Leu Pro Leu 
    610                 615                 620 


<210>  1845
<211>  203
<212>  PRT
<213>  Homo Sapiens

<400>  1845

Met Gly Pro Leu Met Val Leu Phe Cys Leu Leu Phe Leu Tyr Pro Gly 
1               5                   10                  15      


Leu Ala Asp Ser Ala Pro Ser Cys Pro Gln Asn Val Asn Ile Ser Gly 
            20                  25                  30          


Gly Thr Phe Thr Leu Ser His Gly Trp Ala Pro Gly Ser Leu Leu Thr 
        35                  40                  45              


Tyr Ser Cys Pro Gln Gly Leu Tyr Pro Ser Pro Ala Ser Arg Leu Cys 
    50                  55                  60                  


Lys Ser Ser Gly Gln Trp Gln Thr Pro Gly Ala Thr Arg Ser Leu Ser 
65                  70                  75                  80  


Lys Ala Val Cys Lys Pro Gly His Cys Pro Asn Pro Gly Ile Ser Leu 
                85                  90                  95      


Gly Ala Val Arg Thr Gly Phe Arg Phe Gly His Gly Asp Lys Val Arg 
            100                 105                 110         


Tyr Arg Cys Ser Ser Asn Leu Val Leu Thr Gly Ser Ser Glu Arg Glu 
        115                 120                 125             


Cys Gln Gly Asn Gly Val Trp Ser Gly Thr Glu Pro Ile Cys Arg Gln 
    130                 135                 140                 


Pro Tyr Ser Tyr Asp Phe Pro Glu Asp Val Ala Pro Ala Leu Gly Thr 
145                 150                 155                 160 


Ser Phe Ser His Met Leu Gly Ala Thr Asn Pro Thr Gln Lys Thr Lys 
                165                 170                 175     


Glu Ser Leu Gly Arg Lys Ile Gln Ile Gln Arg Ser Gly His Leu Asn 
            180                 185                 190         


Leu Tyr Leu Leu Leu Asp Cys Ser Gln Ser Val 
        195                 200             


<210>  1846
<211>  139
<212>  PRT
<213>  Homo Sapiens

<400>  1846

Met Gly Pro Leu Met Val Leu Phe Cys Leu Leu Phe Leu Tyr Pro Gly 
1               5                   10                  15      


Leu Ala Asp Ser Ala Pro Ser Cys Pro Gln Asn Val Asn Ile Ser Gly 
            20                  25                  30          


Gly Thr Phe Thr Leu Ser His Gly Trp Ala Pro Gly Ser Leu Leu Thr 
        35                  40                  45              


Tyr Ser Cys Pro Gln Gly Leu Tyr Pro Ser Pro Ala Ser Arg Leu Cys 
    50                  55                  60                  


Lys Ser Ser Gly Gln Trp Gln Thr Pro Gly Ala Thr Arg Ser Leu Ser 
65                  70                  75                  80  


Lys Ala Val Cys Lys Pro Val Arg Cys Pro Ala Pro Val Ser Phe Glu 
                85                  90                  95      


Asn Gly Ile Tyr Thr Pro Arg Leu Gly Ser Tyr Pro Val Gly Gly Asn 
            100                 105                 110         


Val Ser Phe Glu Cys Glu Asp Gly Phe Ile Leu Arg Gly Ser Pro Val 
        115                 120                 125             


Arg Gln Cys Arg Pro Asn Gly Met Trp Asp Gly 
    130                 135                 


<210>  1847
<211>  752
<212>  PRT
<213>  Homo Sapiens

<400>  1847

Met Gly Pro Leu Met Val Leu Phe Cys Leu Leu Phe Leu Tyr Pro Gly 
1               5                   10                  15      


Leu Ala Asp Ser Ala Pro Ser Cys Pro Gln Asn Val Asn Ile Ser Gly 
            20                  25                  30          


Gly Thr Phe Thr Leu Ser His Gly Trp Ala Pro Gly Ser Leu Leu Thr 
        35                  40                  45              


Tyr Ser Cys Pro Gln Gly Leu Tyr Pro Ser Pro Ala Ser Arg Leu Cys 
    50                  55                  60                  


Lys Ser Ser Gly Gln Trp Gln Thr Pro Gly Ala Thr Arg Ser Leu Ser 
65                  70                  75                  80  


Lys Ala Val Cys Lys Pro Val Arg Cys Pro Ala Pro Val Ser Phe Glu 
                85                  90                  95      


Asn Gly Ile Tyr Thr Pro Arg Leu Gly Ser Tyr Pro Val Gly Gly Asn 
            100                 105                 110         


Val Ser Phe Glu Cys Glu Asp Gly Phe Ile Leu Arg Gly Ser Pro Val 
        115                 120                 125             


Arg Gln Cys Arg Pro Asn Gly Met Trp Asp Gly Glu Thr Ala Val Cys 
    130                 135                 140                 


Asp Asn Gly Ala Gly His Cys Pro Asn Pro Gly Ile Ser Leu Gly Ala 
145                 150                 155                 160 


Val Arg Thr Gly Phe Arg Phe Gly His Gly Asp Lys Val Arg Tyr Arg 
                165                 170                 175     


Cys Ser Ser Asn Leu Val Leu Thr Gly Ser Ser Glu Arg Glu Cys Gln 
            180                 185                 190         


Gly Asn Gly Val Trp Ser Gly Thr Glu Pro Ile Cys Arg Gln Pro Tyr 
        195                 200                 205             


Ser Tyr Asp Phe Pro Glu Asp Val Ala Pro Ala Leu Gly Thr Ser Phe 
    210                 215                 220                 


Ser His Met Leu Gly Ala Thr Asn Pro Thr Gln Lys Thr Lys Glu Ser 
225                 230                 235                 240 


Leu Gly Arg Lys Ile Gln Ile Gln Arg Ser Gly His Leu Asn Leu Tyr 
                245                 250                 255     


Leu Leu Leu Asp Cys Ser Gln Ser Val Ser Glu Asn Asp Phe Leu Ile 
            260                 265                 270         


Phe Lys Glu Ser Ala Ser Leu Met Val Asp Arg Ile Phe Ser Phe Glu 
        275                 280                 285             


Ile Asn Val Ser Val Ala Ile Ile Thr Phe Ala Ser Glu Pro Lys Val 
    290                 295                 300                 


Leu Met Ser Val Leu Asn Asp Asn Ser Arg Asp Met Thr Glu Val Ile 
305                 310                 315                 320 


Ser Ser Leu Glu Asn Ala Asn Tyr Lys Asp His Glu Asn Gly Thr Gly 
                325                 330                 335     


Thr Asn Thr Tyr Ala Ala Leu Asn Ser Val Tyr Leu Met Met Asn Asn 
            340                 345                 350         


Gln Met Arg Leu Leu Gly Met Glu Thr Met Ala Trp Gln Glu Ile Arg 
        355                 360                 365             


His Ala Ile Ile Leu Leu Thr Asp Gly Lys Ser Asn Met Gly Gly Ser 
    370                 375                 380                 


Pro Lys Thr Ala Val Asp His Ile Arg Glu Ile Leu Asn Ile Asn Gln 
385                 390                 395                 400 


Lys Arg Asn Asp Tyr Leu Asp Ile Tyr Ala Ile Gly Val Gly Lys Leu 
                405                 410                 415     


Asp Val Asp Trp Arg Glu Leu Asn Glu Leu Gly Ser Lys Lys Asp Gly 
            420                 425                 430         


Glu Arg His Ala Phe Ile Leu Gln Asp Thr Lys Ala Leu His Gln Val 
        435                 440                 445             


Phe Glu His Met Leu Asp Val Ser Lys Leu Thr Asp Thr Ile Cys Gly 
    450                 455                 460                 


Val Gly Asn Met Ser Ala Asn Ala Ser Asp Gln Glu Arg Thr Pro Trp 
465                 470                 475                 480 


His Val Thr Ile Lys Pro Lys Ser Gln Glu Thr Cys Arg Gly Ala Leu 
                485                 490                 495     


Ile Ser Asp Gln Trp Val Leu Thr Ala Ala His Cys Phe Arg Asp Gly 
            500                 505                 510         


Asn Asp His Ser Leu Trp Arg Val Asn Val Gly Asp Pro Lys Ser Gln 
        515                 520                 525             


Trp Gly Lys Glu Phe Leu Ile Glu Lys Ala Val Ile Ser Pro Gly Phe 
    530                 535                 540                 


Asp Val Phe Ala Lys Lys Asn Gln Gly Ile Leu Glu Phe Tyr Gly Asp 
545                 550                 555                 560 


Asp Ile Ala Leu Leu Lys Leu Ala Gln Lys Val Lys Met Ser Thr His 
                565                 570                 575     


Ala Arg Pro Ile Cys Leu Pro Cys Thr Met Glu Ala Asn Leu Ala Leu 
            580                 585                 590         


Arg Arg Pro Gln Gly Ser Thr Cys Arg Asp His Glu Asn Glu Leu Leu 
        595                 600                 605             


Asn Lys Gln Ser Val Pro Ala His Phe Val Ala Leu Asn Gly Ser Lys 
    610                 615                 620                 


Leu Asn Ile Asn Leu Lys Met Gly Val Glu Trp Thr Ser Cys Ala Glu 
625                 630                 635                 640 


Val Val Ser Gln Glu Lys Thr Met Phe Pro Asn Leu Thr Asp Val Arg 
                645                 650                 655     


Glu Val Val Thr Asp Gln Phe Leu Cys Ser Gly Thr Gln Glu Asp Glu 
            660                 665                 670         


Ser Pro Cys Lys Gly Glu Ser Gly Gly Ala Val Phe Leu Glu Arg Arg 
        675                 680                 685             


Phe Arg Phe Phe Gln Val Gly Leu Val Ser Trp Gly Leu Tyr Asn Pro 
    690                 695                 700                 


Cys Leu Gly Ser Ala Asp Lys Asn Ser Arg Lys Arg Ala Pro Arg Ser 
705                 710                 715                 720 


Lys Val Pro Pro Pro Arg Asp Phe His Ile Asn Leu Phe Arg Met Gln 
                725                 730                 735     


Pro Trp Leu Arg Gln His Leu Gly Asp Val Leu Asn Phe Leu Pro Leu 
            740                 745                 750         


<210>  1848
<211>  328
<212>  PRT
<213>  Homo Sapiens

<400>  1848

Met Gly Pro Leu Met Val Leu Phe Cys Leu Leu Phe Leu Tyr Pro Gly 
1               5                   10                  15      


Leu Ala Asp Ser Ala Pro Ser Cys Pro Gln Asn Val Asn Ile Ser Gly 
            20                  25                  30          


Gly Thr Phe Thr Leu Ser His Gly Trp Ala Pro Gly Ser Leu Leu Thr 
        35                  40                  45              


Tyr Ser Cys Pro Gln Gly Leu Tyr Pro Ser Pro Ala Ser Arg Leu Cys 
    50                  55                  60                  


Lys Ser Ser Gly Gln Trp Gln Thr Pro Gly Ala Thr Arg Ser Leu Ser 
65                  70                  75                  80  


Lys Ala Val Cys Lys Pro Val Arg Cys Pro Ala Pro Val Ser Phe Glu 
                85                  90                  95      


Asn Gly Ile Tyr Thr Pro Arg Leu Gly Ser Tyr Pro Val Gly Gly Asn 
            100                 105                 110         


Val Ser Phe Glu Cys Glu Asp Gly Phe Ile Leu Arg Gly Ser Pro Val 
        115                 120                 125             


Arg Gln Cys Arg Pro Asn Gly Met Trp Asp Gly Glu Thr Ala Val Cys 
    130                 135                 140                 


Asp Asn Gly Ala Gly His Cys Pro Asn Pro Gly Ile Ser Leu Gly Ala 
145                 150                 155                 160 


Val Arg Thr Gly Phe Arg Phe Gly His Gly Asp Lys Val Arg Tyr Arg 
                165                 170                 175     


Cys Ser Ser Asn Leu Val Leu Thr Gly Ser Ser Glu Arg Glu Cys Gln 
            180                 185                 190         


Gly Asn Gly Val Trp Ser Gly Thr Glu Pro Ile Cys Arg Gln Pro Tyr 
        195                 200                 205             


Ser Tyr Asp Phe Pro Glu Asp Val Ala Pro Ala Leu Gly Thr Ser Phe 
    210                 215                 220                 


Ser His Met Leu Gly Ala Thr Asn Pro Thr Gln Lys Thr Lys Glu Ser 
225                 230                 235                 240 


Leu Gly Arg Lys Ile Gln Ile Gln Arg Ser Gly His Leu Asn Leu Tyr 
                245                 250                 255     


Leu Leu Leu Asp Cys Ser Gln Ser Val Ser Glu Asn Asp Phe Leu Ile 
            260                 265                 270         


Phe Lys Glu Ser Ala Ser Leu Met Val Asp Arg Val Arg Asn Gln Glu 
        275                 280                 285             


Ser Ala Cys Ser Arg Gly Leu Pro Val Leu Thr Ile Ser Leu Cys Leu 
    290                 295                 300                 


Leu Pro Leu Leu Arg Thr Pro Leu Thr Ala His Leu Leu Gln Glu Val 
305                 310                 315                 320 


Phe Ser Asp Tyr Thr His Ala Met 
                325             


<210>  1849
<211>  104
<212>  PRT
<213>  Homo Sapiens

<400>  1849

Met Gly Pro Leu Met Val Leu Phe Cys Leu Leu Phe Leu Tyr Pro Gly 
1               5                   10                  15      


Leu Ala Asp Ser Ala Pro Ser Cys Pro Gln Asn Val Asn Ile Ser Gly 
            20                  25                  30          


Gly Thr Phe Thr Leu Ser His Gly Trp Ala Pro Gly Ser Leu Leu Thr 
        35                  40                  45              


Tyr Ser Cys Pro Gln Gly Leu Tyr Pro Ser Pro Ala Ser Arg Leu Cys 
    50                  55                  60                  


Lys Ser Ser Gly Gln Trp Gln Thr Pro Gly Ala Thr Arg Ser Leu Ser 
65                  70                  75                  80  


Lys Ala Val Cys Lys Arg Glu Ala Pro Cys Gly Leu Cys Ser Gly Cys 
                85                  90                  95      


Ala Leu Ser Ser Pro Cys Leu Leu 
            100                 


<210>  1850
<211>  136
<212>  PRT
<213>  Homo Sapiens

<400>  1850

Met Gly Arg Pro Gly Arg Ala Gly His Cys Pro Asn Pro Gly Ile Ser 
1               5                   10                  15      


Leu Gly Ala Val Arg Thr Gly Phe Arg Phe Gly His Gly Asp Lys Val 
            20                  25                  30          


Arg Tyr Arg Cys Ser Ser Asn Leu Val Leu Thr Gly Ser Ser Glu Arg 
        35                  40                  45              


Glu Cys Gln Gly Asn Gly Val Trp Ser Gly Thr Glu Pro Ile Cys Arg 
    50                  55                  60                  


Gln Pro Tyr Ser Tyr Asp Phe Pro Glu Asp Val Ala Pro Ala Leu Gly 
65                  70                  75                  80  


Thr Ser Phe Ser His Met Leu Gly Ala Thr Asn Pro Thr Gln Lys Thr 
                85                  90                  95      


Lys Glu Ser Leu Gly Arg Lys Ile Gln Ile Gln Arg Ser Gly His Leu 
            100                 105                 110         


Asn Leu Tyr Leu Leu Leu Asp Cys Ser Gln Ser Val Ser Glu Asn Asp 
        115                 120                 125             


Phe Leu Ile Phe Lys Glu Ser Ala 
    130                 135     


<210>  1851
<211>  506
<212>  PRT
<213>  Homo Sapiens

<400>  1851

Met Gly Thr Arg Ser Ala Ile Ala Ala Pro Arg Ile Leu Cys Ser Arg 
1               5                   10                  15      


Gly Leu Arg Ser Gly Ser Ala Arg Ala Thr Gly Ser Gly Val Glu Arg 
            20                  25                  30          


Ser Pro Ser Ala Ala Ile Phe Ser Phe Glu Ile Asn Val Ser Val Ala 
        35                  40                  45              


Ile Ile Thr Phe Ala Ser Glu Pro Lys Val Leu Met Ser Val Leu Asn 
    50                  55                  60                  


Asp Asn Ser Arg Asp Met Thr Glu Val Ile Ser Ser Leu Glu Asn Ala 
65                  70                  75                  80  


Asn Tyr Lys Asp His Glu Asn Gly Thr Gly Thr Asn Thr Tyr Ala Ala 
                85                  90                  95      


Leu Asn Ser Val Tyr Leu Met Met Asn Asn Gln Met Arg Leu Leu Gly 
            100                 105                 110         


Met Glu Thr Met Ala Trp Gln Glu Ile Arg His Ala Ile Ile Leu Leu 
        115                 120                 125             


Thr Asp Gly Lys Ser Asn Met Gly Gly Ser Pro Lys Thr Ala Val Asp 
    130                 135                 140                 


His Ile Arg Glu Ile Leu Asn Ile Asn Gln Lys Arg Asn Asp Tyr Leu 
145                 150                 155                 160 


Asp Ile Tyr Ala Ile Gly Val Gly Lys Leu Asp Val Asp Trp Arg Glu 
                165                 170                 175     


Leu Asn Glu Leu Gly Ser Lys Lys Asp Gly Glu Arg His Ala Phe Ile 
            180                 185                 190         


Leu Gln Asp Thr Lys Ala Leu His Gln Val Phe Glu His Met Leu Asp 
        195                 200                 205             


Val Ser Lys Leu Thr Asp Thr Ile Cys Gly Val Gly Asn Met Ser Ala 
    210                 215                 220                 


Asn Ala Ser Asp Gln Glu Arg Thr Pro Trp His Val Thr Ile Lys Pro 
225                 230                 235                 240 


Lys Ser Gln Glu Thr Cys Arg Gly Ala Leu Ile Ser Asp Gln Trp Val 
                245                 250                 255     


Leu Thr Ala Ala His Cys Phe Arg Asp Gly Asn Asp His Ser Leu Trp 
            260                 265                 270         


Arg Val Asn Val Gly Asp Pro Lys Ser Gln Trp Gly Lys Glu Phe Leu 
        275                 280                 285             


Ile Glu Lys Ala Val Ile Ser Pro Gly Phe Asp Val Phe Ala Lys Lys 
    290                 295                 300                 


Asn Gln Gly Ile Leu Glu Phe Tyr Gly Asp Asp Ile Ala Leu Leu Lys 
305                 310                 315                 320 


Leu Ala Gln Lys Val Lys Met Ser Thr His Ala Arg Pro Ile Cys Leu 
                325                 330                 335     


Pro Cys Thr Met Glu Ala Asn Leu Ala Leu Arg Arg Pro Gln Gly Ser 
            340                 345                 350         


Thr Cys Arg Asp His Glu Asn Glu Leu Leu Asn Lys Gln Ser Val Pro 
        355                 360                 365             


Ala His Phe Val Ala Leu Asn Gly Ser Lys Leu Asn Ile Asn Leu Lys 
    370                 375                 380                 


Met Gly Val Glu Trp Thr Ser Cys Ala Glu Val Val Ser Gln Glu Lys 
385                 390                 395                 400 


Thr Met Phe Pro Asn Leu Thr Asp Val Arg Glu Val Val Thr Asp Gln 
                405                 410                 415     


Phe Leu Cys Ser Gly Thr Gln Glu Asp Glu Ser Pro Cys Lys Gly Glu 
            420                 425                 430         


Ser Gly Gly Ala Val Phe Leu Glu Arg Arg Phe Arg Phe Phe Gln Val 
        435                 440                 445             


Gly Leu Val Ser Trp Gly Leu Tyr Asn Pro Cys Leu Gly Ser Ala Asp 
    450                 455                 460                 


Lys Asn Ser Arg Lys Arg Ala Pro Arg Ser Lys Val Pro Pro Pro Arg 
465                 470                 475                 480 


Asp Phe His Ile Asn Leu Phe Arg Met Gln Pro Trp Leu Arg Gln His 
                485                 490                 495     


Leu Gly Asp Val Leu Asn Phe Leu Pro Leu 
            500                 505     


<210>  1852
<211>  463
<212>  PRT
<213>  Homo Sapiens

<400>  1852

Met Gly Thr Arg Ser Ala Ile Ala Ala Pro Arg Ile Leu Cys Ser Arg 
1               5                   10                  15      


Gly Leu Arg Ser Gly Ser Ala Arg Ala Thr Gly Ser Gly Val Glu Arg 
            20                  25                  30          


Ser Pro Ser Ala Ala Asn Pro Thr Leu Met Thr Ser Leu Arg Thr Trp 
        35                  40                  45              


Pro Leu Pro Trp Ala Leu Pro Ser Pro Thr Cys Leu Gly Pro Pro Ile 
    50                  55                  60                  


Pro Pro Arg Arg Gln Arg Ile Phe Ser Phe Glu Ile Asn Val Ser Val 
65                  70                  75                  80  


Ala Ile Ile Thr Phe Ala Ser Glu Pro Lys Val Leu Met Ser Val Leu 
                85                  90                  95      


Asn Asp Asn Ser Arg Asp Met Thr Glu Val Ile Ser Ser Leu Glu Asn 
            100                 105                 110         


Ala Asn Tyr Lys Asp His Glu Asn Gly Thr Gly Thr Asn Thr Tyr Ala 
        115                 120                 125             


Ala Leu Asn Ser Val Tyr Leu Met Met Asn Asn Gln Met Arg Leu Leu 
    130                 135                 140                 


Gly Met Glu Thr Met Ala Trp Gln Glu Ile Arg His Ala Ile Ile Leu 
145                 150                 155                 160 


Leu Thr Asp Gly Lys Ser Asn Met Gly Gly Ser Pro Lys Thr Ala Val 
                165                 170                 175     


Asp His Ile Arg Glu Ile Leu Asn Ile Asn Gln Lys Arg Asn Asp Tyr 
            180                 185                 190         


Leu Asp Ile Tyr Ala Ile Gly Val Gly Lys Leu Asp Val Asp Trp Arg 
        195                 200                 205             


Glu Leu Asn Glu Leu Gly Ser Lys Lys Asp Gly Glu Arg His Ala Phe 
    210                 215                 220                 


Ile Leu Gln Asp Thr Lys Ala Leu His Gln Val Phe Glu His Met Leu 
225                 230                 235                 240 


Asp Val Ser Lys Leu Thr Asp Thr Ile Cys Gly Val Gly Asn Met Ser 
                245                 250                 255     


Ala Asn Ala Ser Asp Gln Glu Arg Thr Pro Trp His Val Thr Ile Lys 
            260                 265                 270         


Pro Lys Ser Gln Glu Thr Cys Arg Gly Ala Leu Ile Ser Asp Gln Trp 
        275                 280                 285             


Val Leu Thr Ala Ala His Cys Phe Arg Asp Gly Asn Asp His Ser Leu 
    290                 295                 300                 


Trp Arg Val Asn Val Gly Asp Pro Lys Ser Gln Trp Gly Lys Glu Phe 
305                 310                 315                 320 


Leu Ile Glu Lys Ala Val Ile Ser Pro Gly Phe Asp Val Phe Ala Lys 
                325                 330                 335     


Lys Asn Gln Gly Ile Leu Glu Phe Tyr Gly Asp Asp Ile Ala Leu Leu 
            340                 345                 350         


Lys Leu Ala Gln Lys Val Lys Met Ser Thr His Ala Arg Pro Ile Cys 
        355                 360                 365             


Leu Pro Cys Thr Met Glu Ala Asn Leu Ala Leu Arg Arg Pro Gln Gly 
    370                 375                 380                 


Ser Thr Cys Arg Asp His Glu Asn Glu Leu Leu Asn Lys Gln Ser Val 
385                 390                 395                 400 


Pro Ala His Phe Val Ala Leu Asn Gly Ser Lys Leu Asn Ile Asn Leu 
                405                 410                 415     


Lys Met Gly Val Glu Trp Thr Ser Cys Ala Glu Val Val Ser Gln Glu 
            420                 425                 430         


Lys Thr Met Phe Pro Asn Leu Thr Asp Val Arg Glu Val Val Thr Asp 
        435                 440                 445             


Gln Phe Leu Cys Ser Gly Thr Gln Glu Asp Glu Ser Pro Cys Lys 
    450                 455                 460             


<210>  1853
<211>  84
<212>  PRT
<213>  Homo Sapiens

<400>  1853

Met Gly Thr Arg Ser Ala Ile Ala Ala Pro Arg Ile Leu Cys Ser Arg 
1               5                   10                  15      


Gly Leu Arg Ser Gly Ser Ala Arg Ala Thr Gly Ser Gly Val Glu Arg 
            20                  25                  30          


Ser Pro Ser Ala Ala Asn Pro Thr Leu Met Thr Ser Leu Arg Thr Trp 
        35                  40                  45              


Pro Leu Pro Trp Ala Leu Pro Ser Pro Thr Cys Leu Gly Pro Pro Ile 
    50                  55                  60                  


Pro Pro Arg Arg Gln Arg Lys Ala Trp Ala Val Lys Ser Lys Ser Ser 
65                  70                  75                  80  


Ala Leu Val Ile 
                


<210>  1854
<211>  84
<212>  PRT
<213>  Homo Sapiens

<400>  1854

Met Gly Thr Arg Ser Ala Ile Ala Ala Pro Arg Ile Leu Cys Ser Arg 
1               5                   10                  15      


Gly Leu Arg Ser Gly Ser Ala Arg Ala Thr Gly Ser Gly Val Glu Arg 
            20                  25                  30          


Ser Pro Ser Ala Ala Asn Pro Thr Leu Met Thr Ser Leu Arg Thr Trp 
        35                  40                  45              


Pro Leu Pro Trp Ala Leu Pro Ser Pro Thr Cys Leu Gly Pro Pro Ile 
    50                  55                  60                  


Pro Pro Arg Arg Gln Arg Lys Ala Trp Ala Val Lys Ser Lys Ser Ser 
65                  70                  75                  80  


Ala Leu Val Ile 
                


<210>  1855
<211>  538
<212>  PRT
<213>  Homo Sapiens

<400>  1855

Met Arg Ala Leu Cys Ile Arg Glu Thr Cys Ser Ser Glu Leu Gly Phe 
1               5                   10                  15      


Ser Arg Asn Trp Ser Arg Arg Lys Ala Gly His Cys Pro Asn Pro Gly 
            20                  25                  30          


Ile Ser Leu Gly Ala Val Arg Thr Gly Phe Arg Phe Gly His Gly Asp 
        35                  40                  45              


Lys Val Arg Tyr Arg Cys Ser Ser Asn Leu Val Leu Thr Gly Ser Ser 
    50                  55                  60                  


Glu Arg Glu Cys Gln Gly Asn Gly Val Trp Ser Gly Thr Glu Pro Ile 
65                  70                  75                  80  


Cys Arg Gln Pro Tyr Ser Tyr Asp Phe Pro Glu Asp Val Ala Pro Ala 
                85                  90                  95      


Leu Gly Thr Ser Phe Ser His Met Leu Gly Ala Thr Asn Pro Thr Gln 
            100                 105                 110         


Lys Thr Lys Asp His Glu Asn Gly Thr Gly Thr Asn Thr Tyr Ala Ala 
        115                 120                 125             


Leu Asn Ser Val Tyr Leu Met Met Asn Asn Gln Met Arg Leu Leu Gly 
    130                 135                 140                 


Met Glu Thr Met Ala Trp Gln Glu Ile Arg His Ala Ile Ile Leu Leu 
145                 150                 155                 160 


Thr Asp Gly Lys Ser Asn Met Gly Gly Ser Pro Lys Thr Ala Val Asp 
                165                 170                 175     


His Ile Arg Glu Ile Leu Asn Ile Asn Gln Lys Arg Asn Asp Tyr Leu 
            180                 185                 190         


Asp Ile Tyr Ala Ile Gly Val Gly Lys Leu Asp Val Asp Trp Arg Glu 
        195                 200                 205             


Leu Asn Glu Leu Gly Ser Lys Lys Asp Gly Glu Arg His Ala Phe Ile 
    210                 215                 220                 


Leu Gln Asp Thr Lys Ala Leu His Gln Val Phe Glu His Met Leu Asp 
225                 230                 235                 240 


Val Ser Lys Leu Thr Asp Thr Ile Cys Gly Val Gly Asn Met Ser Ala 
                245                 250                 255     


Asn Ala Ser Asp Gln Glu Arg Thr Pro Trp His Val Thr Ile Lys Pro 
            260                 265                 270         


Lys Ser Gln Glu Thr Cys Arg Gly Ala Leu Ile Ser Asp Gln Trp Val 
        275                 280                 285             


Leu Thr Ala Ala His Cys Phe Arg Asp Gly Asn Asp His Ser Leu Trp 
    290                 295                 300                 


Arg Val Asn Val Gly Asp Pro Lys Ser Gln Trp Gly Lys Glu Phe Leu 
305                 310                 315                 320 


Ile Glu Lys Ala Val Ile Ser Pro Gly Phe Asp Val Phe Ala Lys Lys 
                325                 330                 335     


Asn Gln Gly Ile Leu Glu Phe Tyr Gly Asp Asp Ile Ala Leu Leu Lys 
            340                 345                 350         


Leu Ala Gln Lys Val Lys Met Ser Thr His Ala Arg Pro Ile Cys Leu 
        355                 360                 365             


Pro Cys Thr Met Glu Ala Asn Leu Ala Leu Arg Arg Pro Gln Gly Ser 
    370                 375                 380                 


Thr Cys Arg Asp His Glu Asn Glu Leu Leu Asn Lys Gln Ser Val Pro 
385                 390                 395                 400 


Ala His Phe Val Ala Leu Asn Gly Ser Lys Leu Asn Ile Asn Leu Lys 
                405                 410                 415     


Met Gly Val Glu Trp Thr Ser Cys Ala Glu Val Val Ser Gln Glu Lys 
            420                 425                 430         


Thr Met Phe Pro Asn Leu Thr Asp Val Arg Glu Val Val Thr Asp Gln 
        435                 440                 445             


Phe Leu Cys Ser Gly Thr Gln Glu Asp Glu Ser Pro Cys Lys Gly Glu 
    450                 455                 460                 


Ser Gly Gly Ala Val Phe Leu Glu Arg Arg Phe Arg Phe Phe Gln Val 
465                 470                 475                 480 


Gly Leu Val Ser Trp Gly Leu Tyr Asn Pro Cys Leu Gly Ser Ala Asp 
                485                 490                 495     


Lys Asn Ser Arg Lys Arg Ala Pro Arg Ser Lys Val Pro Pro Pro Arg 
            500                 505                 510         


Asp Phe His Ile Asn Leu Phe Arg Met Gln Pro Trp Leu Arg Gln His 
        515                 520                 525             


Leu Gly Asp Val Leu Asn Phe Leu Pro Leu 
    530                 535             


<210>  1856
<211>  158
<212>  PRT
<213>  Homo Sapiens

<400>  1856

Met Arg Ala Leu Cys Ile Arg Glu Thr Cys Ser Ser Glu Leu Gly Phe 
1               5                   10                  15      


Ser Arg Asn Trp Ser Arg Arg Lys Ala Gly His Cys Pro Asn Pro Gly 
            20                  25                  30          


Ile Ser Leu Gly Ala Val Arg Thr Gly Phe Arg Phe Gly His Gly Asp 
        35                  40                  45              


Lys Val Arg Tyr Arg Cys Ser Ser Asn Leu Val Leu Thr Gly Ser Ser 
    50                  55                  60                  


Glu Arg Glu Cys Gln Gly Asn Gly Val Trp Ser Gly Thr Glu Pro Ile 
65                  70                  75                  80  


Cys Arg Gln Pro Tyr Ser Tyr Asp Phe Pro Glu Asp Val Ala Pro Ala 
                85                  90                  95      


Leu Gly Thr Ser Phe Ser His Met Leu Gly Ala Thr Asn Pro Thr Gln 
            100                 105                 110         


Lys Thr Lys Glu Ser Leu Gly Arg Lys Ile Gln Ile Gln Arg Ser Gly 
        115                 120                 125             


His Leu Asn Leu Tyr Leu Leu Leu Asp Cys Ser Gln Ser Val Ser Glu 
    130                 135                 140                 


Asn Asp Phe Leu Ile Phe Lys Glu Ser Ala Ser Leu Met Val 
145                 150                 155             


<210>  1857
<211>  160
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1857

Xaa Leu Met Val Asp Arg Ile Phe Ser Phe Glu Ile Asn Val Ser Val 
1               5                   10                  15      


Ala Ile Ile Thr Phe Ala Ser Glu Pro Lys Val Leu Met Ser Val Leu 
            20                  25                  30          


Asn Asp Asn Ser Arg Asp Met Thr Glu Val Ile Ser Ser Leu Glu Asn 
        35                  40                  45              


Ala Asn Tyr Lys Asp His Glu Asn Gly Thr Gly Thr Asn Thr Tyr Ala 
    50                  55                  60                  


Ala Leu Asn Ser Val Tyr Leu Met Met Asn Asn Gln Met Arg Leu Leu 
65                  70                  75                  80  


Gly Met Glu Thr Met Ala Trp Gln Glu Ile Arg His Ala Ile Ile Leu 
                85                  90                  95      


Leu Thr Asp Gly Lys Ser Asn Met Gly Gly Ser Pro Lys Thr Ala Val 
            100                 105                 110         


Asp His Ile Arg Glu Ile Leu Asn Ile Asn Gln Lys Arg Asn Asp Tyr 
        115                 120                 125             


Leu Ala Pro Lys Pro Gln Glu Ser Gly Asp Phe Pro Leu Pro His Gln 
    130                 135                 140                 


Thr Ser Met Pro Ser Gly Trp Ala Ser Trp Met Trp Thr Gly Glu Asn 
145                 150                 155                 160 


<210>  1858
<211>  526
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1858

Xaa Met Val Leu Phe Cys Leu Leu Phe Leu Tyr Pro Ala Gly His Cys 
1               5                   10                  15      


Pro Asn Pro Gly Ile Ser Leu Gly Ala Val Arg Thr Gly Phe Arg Phe 
            20                  25                  30          


Gly His Gly Asp Lys Val Arg Tyr Arg Cys Ser Ser Asn Leu Val Leu 
        35                  40                  45              


Thr Gly Ser Ser Glu Arg Glu Cys Gln Gly Asn Gly Val Trp Ser Gly 
    50                  55                  60                  


Thr Glu Pro Ile Cys Arg Gln Pro Tyr Ser Tyr Asp Phe Pro Glu Asp 
65                  70                  75                  80  


Val Ala Pro Ala Leu Gly Thr Ser Phe Ser His Met Leu Gly Ala Thr 
                85                  90                  95      


Asn Pro Thr Gln Lys Thr Lys Asp His Glu Asn Gly Thr Gly Thr Asn 
            100                 105                 110         


Thr Tyr Ala Ala Leu Asn Ser Val Tyr Leu Met Met Asn Asn Gln Met 
        115                 120                 125             


Arg Leu Leu Gly Met Glu Thr Met Ala Trp Gln Glu Ile Arg His Ala 
    130                 135                 140                 


Ile Ile Leu Leu Thr Asp Gly Lys Ser Asn Met Gly Gly Ser Pro Lys 
145                 150                 155                 160 


Thr Ala Val Asp His Ile Arg Glu Ile Leu Asn Ile Asn Gln Lys Arg 
                165                 170                 175     


Asn Asp Tyr Leu Asp Ile Tyr Ala Ile Gly Val Gly Lys Leu Asp Val 
            180                 185                 190         


Asp Trp Arg Glu Leu Asn Glu Leu Gly Ser Lys Lys Asp Gly Glu Arg 
        195                 200                 205             


His Ala Phe Ile Leu Gln Asp Thr Lys Ala Leu His Gln Val Phe Glu 
    210                 215                 220                 


His Met Leu Asp Val Ser Lys Leu Thr Asp Thr Ile Cys Gly Val Gly 
225                 230                 235                 240 


Asn Met Ser Ala Asn Ala Ser Asp Gln Glu Arg Thr Pro Trp His Val 
                245                 250                 255     


Thr Ile Lys Pro Lys Ser Gln Glu Thr Cys Arg Gly Ala Leu Ile Ser 
            260                 265                 270         


Asp Gln Trp Val Leu Thr Ala Ala His Cys Phe Arg Asp Gly Asn Asp 
        275                 280                 285             


His Ser Leu Trp Arg Val Asn Val Gly Asp Pro Lys Ser Gln Trp Gly 
    290                 295                 300                 


Lys Glu Phe Leu Ile Glu Lys Ala Val Ile Ser Pro Gly Phe Asp Val 
305                 310                 315                 320 


Phe Ala Lys Lys Asn Gln Gly Ile Leu Glu Phe Tyr Gly Asp Asp Ile 
                325                 330                 335     


Ala Leu Leu Lys Leu Ala Gln Lys Val Lys Met Ser Thr His Ala Arg 
            340                 345                 350         


Pro Ile Cys Leu Pro Cys Thr Met Glu Ala Asn Leu Ala Leu Arg Arg 
        355                 360                 365             


Pro Gln Gly Ser Thr Cys Arg Asp His Glu Asn Glu Leu Leu Asn Lys 
    370                 375                 380                 


Gln Ser Val Pro Ala His Phe Val Ala Leu Asn Gly Ser Lys Leu Asn 
385                 390                 395                 400 


Ile Asn Leu Lys Met Gly Val Glu Trp Thr Ser Cys Ala Glu Val Val 
                405                 410                 415     


Ser Gln Glu Lys Thr Met Phe Pro Asn Leu Thr Asp Val Arg Glu Val 
            420                 425                 430         


Val Thr Asp Gln Phe Leu Cys Ser Gly Thr Gln Glu Asp Glu Ser Pro 
        435                 440                 445             


Cys Lys Gly Glu Ser Gly Gly Ala Val Phe Leu Glu Arg Arg Phe Arg 
    450                 455                 460                 


Phe Phe Gln Val Gly Leu Val Ser Trp Gly Leu Tyr Asn Pro Cys Leu 
465                 470                 475                 480 


Gly Ser Ala Asp Lys Asn Ser Arg Lys Arg Ala Pro Arg Ser Lys Val 
                485                 490                 495     


Pro Pro Pro Arg Asp Phe His Ile Asn Leu Phe Arg Met Gln Pro Trp 
            500                 505                 510         


Leu Arg Gln His Leu Gly Asp Val Leu Asn Phe Leu Pro Leu 
        515                 520                 525     


<210>  1859
<211>  57
<212>  PRT
<213>  Homo Sapiens

<400>  1859

Met Ala Ala Val Arg Val Leu Val Ala Ser Arg Leu Ala Ala Ala Ser 
1               5                   10                  15      


Ala Phe Thr Ser Leu Ser Pro Gly Gly Arg Thr Pro Ser Gln Arg Ala 
            20                  25                  30          


Ala Leu His Leu Ser Val Pro Arg Pro Ala Ala Arg Val Ala Leu Asp 
        35                  40                  45              


Pro Gly Ala Pro Glu Pro Trp Arg Gly 
    50                  55          


<210>  1860
<211>  163
<212>  PRT
<213>  Homo Sapiens

<400>  1860

Met Ala Ala Val Arg Val Leu Val Ala Ser Arg Leu Ala Ala Ala Ser 
1               5                   10                  15      


Ala Phe Thr Ser Leu Ser Pro Gly Gly Arg Thr Pro Ser Gln Arg Ala 
            20                  25                  30          


Ala Leu His Leu Ser Val Pro Arg Pro Ala Ala Arg Val Ala Leu Val 
        35                  40                  45              


Leu Ser Gly Cys Gly Val Tyr Asp Gly Thr Glu Ile His Glu Ala Ser 
    50                  55                  60                  


Ala Ile Leu Val His Leu Ser Arg Gly Gly Ala Glu Val Gln Ile Phe 
65                  70                  75                  80  


Ala Pro Asp Val Pro Gln Met His Val Ile Asp His Thr Lys Gly Gln 
                85                  90                  95      


Pro Ser Glu Gly Glu Ser Arg Asn Val Leu Thr Glu Ser Ala Arg Ile 
            100                 105                 110         


Ala Arg Gly Lys Ile Thr Asp Leu Ala Asn Leu Ser Ala Ala Asn His 
        115                 120                 125             


Asp Ala Ala Ile Phe Pro Gly Gly Phe Gly Ala Ala Lys Asn Leu Asp 
    130                 135                 140                 


Ser Val Ser Leu Trp Thr Ser Ser Leu Trp Asn Cys Glu Arg Tyr Met 
145                 150                 155                 160 


Ser Val Met 
            


<210>  1861
<211>  237
<212>  PRT
<213>  Homo Sapiens

<400>  1861

Met Ala Ala Val Arg Val Leu Val Ala Ser Arg Leu Ala Ala Ala Ser 
1               5                   10                  15      


Ala Phe Thr Ser Leu Ser Pro Gly Gly Arg Thr Pro Ser Gln Arg Ala 
            20                  25                  30          


Ala Leu His Leu Ser Val Pro Arg Pro Ala Ala Arg Val Ala Leu Val 
        35                  40                  45              


Leu Ser Gly Cys Gly Val Tyr Asp Gly Thr Glu Ile His Glu Ala Ser 
    50                  55                  60                  


Ala Ile Leu Val His Leu Ser Arg Gly Gly Ala Glu Val Gln Ile Phe 
65                  70                  75                  80  


Ala Pro Asp Val Pro Gln Met His Val Ile Asp His Thr Lys Gly Gln 
                85                  90                  95      


Pro Ser Glu Gly Glu Ser Arg Asn Val Leu Thr Glu Ser Ala Arg Ile 
            100                 105                 110         


Ala Arg Gly Lys Ile Thr Asp Leu Ala Asn Leu Ser Ala Ala Asn His 
        115                 120                 125             


Asp Ala Ala Ile Phe Pro Gly Gly Phe Gly Ala Ala Lys Asn Leu Leu 
    130                 135                 140                 


Cys Cys Ile Ala Pro Val Leu Ala Ala Lys Val Leu Arg Gly Val Glu 
145                 150                 155                 160 


Val Thr Val Gly His Glu Gln Glu Glu Gly Gly Lys Trp Pro Tyr Ala 
                165                 170                 175     


Gly Thr Ala Glu Ala Ile Lys Ala Leu Gly Ala Lys His Cys Val Lys 
            180                 185                 190         


Glu Val Val Glu Ala His Val Asp Gln Lys Asn Lys Val Val Thr Thr 
        195                 200                 205             


Pro Ala Phe Met Cys Glu Thr Ala Leu His Tyr Ile His Asp Gly Ile 
    210                 215                 220                 


Gly Ala Met Val Arg Lys Val Leu Glu Leu Thr Gly Lys 
225                 230                 235         


<210>  1862
<211>  217
<212>  PRT
<213>  Homo Sapiens

<400>  1862

Met Ala Ala Val Arg Val Leu Val Ala Ser Arg Leu Ala Ala Ala Ser 
1               5                   10                  15      


Ala Phe Thr Ser Leu Ser Pro Gly Gly Arg Thr Pro Ser Gln Arg Ala 
            20                  25                  30          


Ala Leu His Leu Ser Val Pro Arg Pro Ala Ala Arg Val Ala Leu Val 
        35                  40                  45              


Leu Ser Gly Cys Gly Val Tyr Asp Gly Thr Glu Ile His Glu Ala Ser 
    50                  55                  60                  


Ala Ile Leu Val His Leu Ser Arg Gly Gly Ala Glu Val Gln Ile Phe 
65                  70                  75                  80  


Ala Pro Asp Val Pro Gln Met His Val Ile Asp His Thr Lys Gly Gln 
                85                  90                  95      


Pro Ser Glu Gly Glu Ser Arg Asn Val Leu Thr Glu Ser Ala Arg Ile 
            100                 105                 110         


Ala Arg Gly Lys Ile Thr Asp Leu Ala Asn Leu Ser Ala Ala Asn His 
        115                 120                 125             


Asp Ala Ala Ile Phe Pro Gly Gly Phe Gly Ala Ala Lys Asn Leu Ser 
    130                 135                 140                 


Thr Phe Ala Val Asp Gly Lys Asp Cys Lys Val Asn Lys Glu Val Glu 
145                 150                 155                 160 


Arg Val Leu Lys Glu Phe His Gln Ala Gly Lys Pro Ile Gly Cys Asp 
                165                 170                 175     


Ala Ser Thr Ser Leu Pro Ala Pro Ala Pro Trp Trp Ser Trp Asn Ala 
            180                 185                 190         


Ala Leu Cys Cys Pro Gly Leu Ser Cys Val Trp Cys Trp Gln Gly Glu 
        195                 200                 205             


Ser Arg Thr Cys Val Gly Glu His Gln 
    210                 215         


<210>  1863
<211>  268
<212>  PRT
<213>  Homo Sapiens

<400>  1863

Met Ala Ala Val Arg Val Leu Val Ala Ser Arg Leu Ala Ala Ala Ser 
1               5                   10                  15      


Ala Phe Thr Ser Leu Ser Pro Gly Gly Arg Thr Pro Ser Gln Arg Ala 
            20                  25                  30          


Ala Leu His Leu Ser Val Pro Arg Pro Ala Ala Arg Val Ala Leu Val 
        35                  40                  45              


Leu Ser Gly Cys Gly Val Tyr Asp Gly Thr Glu Ile His Glu Ala Ser 
    50                  55                  60                  


Ala Ile Leu Val His Leu Ser Arg Gly Gly Ala Glu Val Gln Ile Phe 
65                  70                  75                  80  


Ala Pro Asp Val Pro Gln Met His Val Ile Asp His Thr Lys Gly Gln 
                85                  90                  95      


Pro Ser Glu Gly Glu Ser Arg Asn Val Leu Thr Glu Ser Ala Arg Ile 
            100                 105                 110         


Ala Arg Gly Lys Ile Thr Asp Leu Ala Asn Leu Ser Ala Ala Asn His 
        115                 120                 125             


Asp Ala Ala Ile Phe Pro Gly Gly Phe Gly Ala Ala Lys Asn Leu Ser 
    130                 135                 140                 


Thr Phe Ala Val Asp Gly Lys Asp Cys Lys Val Asn Lys Glu Val Glu 
145                 150                 155                 160 


Arg Val Leu Lys Glu Phe His Gln Ala Gly Lys Pro Ile Gly Leu Cys 
                165                 170                 175     


Cys Ile Ala Pro Val Leu Ala Ala Lys Val Leu Arg Gly Val Glu Val 
            180                 185                 190         


Thr Val Gly His Glu Gln Glu Glu Gly Gly Lys Trp Pro Tyr Ala Gly 
        195                 200                 205             


Thr Ala Glu Ala Ile Lys Ala Leu Gly Ala Lys His Cys Val Lys Glu 
    210                 215                 220                 


Val Val Glu Ala His Val Asp Gln Lys Asn Lys Val Val Thr Thr Pro 
225                 230                 235                 240 


Ala Phe Met Cys Glu Thr Ala Leu His Tyr Ile His Asp Gly Ile Gly 
                245                 250                 255     


Ala Met Val Arg Lys Val Leu Glu Leu Thr Gly Lys 
            260                 265             


<210>  1864
<211>  224
<212>  PRT
<213>  Homo Sapiens

<400>  1864

Pro Ser Gln Arg Ala Ala Leu His Leu Ser Val Pro Arg Pro Ala Ala 
1               5                   10                  15      


Arg Val Ala Leu Val Leu Ser Gly Cys Gly Val Tyr Asp Gly Thr Glu 
            20                  25                  30          


Ile His Glu Ala Ser Ala Ile Leu Val His Leu Ser Arg Gly Gly Ala 
        35                  40                  45              


Glu Val Gln Ile Phe Ala Pro Asp Val Pro Gln Met His Val Ile Asp 
    50                  55                  60                  


His Thr Lys Gly Gln Pro Ser Glu Gly Glu Ser Arg Asn Val Leu Thr 
65                  70                  75                  80  


Glu Ser Ala Arg Ile Ala Arg Gly Lys Ile Thr Asp Leu Ala Asn Leu 
                85                  90                  95      


Ser Ala Ala Asn His Asp Ala Ala Ile Phe Pro Gly Gly Phe Gly Ala 
            100                 105                 110         


Ala Lys Asn Leu Ser Thr Phe Ala Val Asp Gly Lys Asp Cys Lys Val 
        115                 120                 125             


Asn Lys Glu Val Glu Arg Val Leu Lys Glu Phe His Gln Ala Gly Lys 
    130                 135                 140                 


Pro Ile Gly His Ser Leu Lys Asp Leu Pro Gly His Cys Pro Gly Arg 
145                 150                 155                 160 


Pro Leu Lys Trp Ser Leu Arg Lys Arg Cys Arg Leu Arg Ala Pro Glu 
                165                 170                 175     


Gly Gly Pro Cys Cys Ser Arg Val Thr Ala Gly Val Lys Val Ser Pro 
            180                 185                 190         


Met Val Ser Thr Ser Gly Ser Arg Pro Cys Gln Arg Ser Val Pro Trp 
        195                 200                 205             


Met Ser Ala Gln Arg Glu Glu Pro Met Ala Leu Ser Ser Val Thr Asp 
    210                 215                 220                 


<210>  1865
<211>  184
<212>  PRT
<213>  Homo Sapiens

<400>  1865

Gln Pro Ser Glu Gly Glu Ser Arg Asn Val Leu Thr Glu Ser Ala Arg 
1               5                   10                  15      


Ile Ala Arg Gly Lys Ile Thr Asp Leu Ala Asn Leu Ser Ala Ala Asn 
            20                  25                  30          


His Asp Ala Ala Ile Phe Pro Gly Gly Phe Gly Ala Ala Lys Asn Leu 
        35                  40                  45              


Ser Thr Phe Ala Val Asp Gly Lys Asp Cys Lys Val Asn Lys Glu Val 
    50                  55                  60                  


Glu Arg Val Leu Lys Glu Phe His Gln Ala Gly Lys Pro Ile Gly Leu 
65                  70                  75                  80  


Cys Cys Ile Ala Pro Val Leu Ala Ala Lys Val Leu Arg Gly Val Glu 
                85                  90                  95      


Val Thr Val Gly His Glu Gln Glu Glu Gly Gly Lys Trp Pro Tyr Ala 
            100                 105                 110         


Gly Thr Ala Glu Ala Ile Lys Ala Leu Gly Ala Lys His Cys Val Lys 
        115                 120                 125             


Glu Val Val Glu Ala His Val Asp Gln Lys Asn Lys Val Val Thr Thr 
    130                 135                 140                 


Pro Ala Phe Met Cys Glu Thr Ala Leu His Tyr Ile His Asp Gly Ile 
145                 150                 155                 160 


Gly Ala Met Ala Ser Trp Ala Cys Trp Leu Met Pro Val Ile Pro Ala 
                165                 170                 175     


Leu Trp Glu Ala Lys Ala Arg Gly 
            180                 


<210>  1866
<211>  191
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1866

Xaa Gln Met His Val Ile Asp His Thr Lys Gly Gln Pro Ser Glu Gly 
1               5                   10                  15      


Glu Ser Arg Asn Val Leu Thr Glu Ser Ala Arg Ile Ala Arg Gly Lys 
            20                  25                  30          


Ile Thr Asp Leu Ala Asn Leu Ser Ala Ala Asn His Asp Ala Ala Ile 
        35                  40                  45              


Phe Pro Gly Gly Phe Gly Ala Ala Lys Asn Leu Ser Thr Phe Ala Val 
    50                  55                  60                  


Asp Gly Lys Asp Cys Lys Val Asn Lys Glu Val Glu Arg Val Leu Lys 
65                  70                  75                  80  


Glu Phe His Gln Ala Gly Lys Pro Ile Gly Leu Cys Cys Ile Ala Pro 
                85                  90                  95      


Val Leu Ala Ala Lys Val Leu Arg Gly Val Glu Val Thr Val Gly His 
            100                 105                 110         


Glu Gln Glu Glu Gly Gly Lys Trp Pro Tyr Ala Gly Thr Ala Glu Ala 
        115                 120                 125             


Ile Lys Ala Leu Gly Ala Lys His Cys Val Lys Glu Val Val Glu Ala 
    130                 135                 140                 


His Val Asp Gln Lys Asn Lys Val Val Thr Thr Pro Ala Phe Met Cys 
145                 150                 155                 160 


Glu Thr Ala Leu His Tyr Ile His Asp Gly Ile Gly Ala Met Glu Glu 
                165                 170                 175     


Arg Glu Ile Ala Ala Pro Gln Pro Pro Gly Leu Thr Ser Gly Glu 
            180                 185                 190     


<210>  1867
<211>  190
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1867

Xaa Ser Arg Gly Gly Ala Glu Val Gln Ile Phe Ala Pro Asp Val Pro 
1               5                   10                  15      


Gln Met His Val Ile Asp His Thr Lys Gly Gln Pro Ser Glu Gly Glu 
            20                  25                  30          


Ser Arg Asn Val Leu Thr Glu Ser Ala Arg Ile Ala Arg Gly Lys Ile 
        35                  40                  45              


Thr Asp Leu Ala Asn Leu Ser Ala Ala Asn His Asp Ala Ala Ile Phe 
    50                  55                  60                  


Pro Gly Gly Phe Gly Ala Ala Lys Asn Leu Ser Thr Phe Ala Val Asp 
65                  70                  75                  80  


Gly Lys Asp Cys Lys Val Asn Lys Glu Val Glu Arg Val Leu Lys Glu 
                85                  90                  95      


Phe His Gln Ala Gly Lys Pro Ile Gly Pro Gly Asp Gly Gly Asp Val 
            100                 105                 110         


Ser Met Ser Val Ser Leu Arg Ser Leu Ser Leu Ala Leu Ser Leu Pro 
        115                 120                 125             


Gly Gly Ser Cys Ser Gln Pro Ser Leu Pro Pro His Arg His Pro Ala 
    130                 135                 140                 


Cys Pro Ser Gly Pro Ala Arg Leu Leu Cys Leu Glu Gly Ala Thr Lys 
145                 150                 155                 160 


Glu Glu Asp Val Asn Val Gln Val Leu Arg Glu Ala Gly Pro Ala Ala 
                165                 170                 175     


Ser Val Ser Val Phe Arg Pro Gln Glu Glu Pro Arg Pro Gly 
            180                 185                 190 


<210>  1868
<211>  266
<212>  PRT
<213>  Homo Sapiens

<400>  1868

Cys Arg Leu Asn Gln Leu Ser Ser Gln Gly Glu Gly Ser Val Ala Arg 
1               5                   10                  15      


Gln Arg Ser Val Glu Trp Arg Gly Glu Ala Ser Arg Trp Asn Ser Gln 
            20                  25                  30          


Met Thr Ala Cys Arg His Gln Glu Ser Gly Arg Thr Tyr Arg Arg Gln 
        35                  40                  45              


Pro Cys Thr Glu Leu Gly Thr Cys Asn Asn Asn Ser Thr Leu Gly Val 
    50                  55                  60                  


Phe Ala Leu Asn Cys Phe Thr Lys Gly Gln Lys Asn Ser Thr Leu Ile 
65                  70                  75                  80  


Phe Thr Arg Glu Asn Thr Ile Arg Asn Cys Ser Cys Ser Ala Asp Ile 
                85                  90                  95      


Arg Asp Cys Asp Tyr Ser Leu Ala Asn Leu Met Cys Asn Cys Lys Thr 
            100                 105                 110         


Val Leu Pro Leu Ala Val Glu Arg Thr Ser Tyr Asn Gly His Leu Thr 
        115                 120                 125             


Ile Trp Phe Thr Asp Thr Ser Ala Leu Gly His Leu Leu Asn Phe Thr 
    130                 135                 140                 


Leu Val Gln Asp Leu Lys Leu Ser Leu Cys Ser Thr Asn Thr Leu Pro 
145                 150                 155                 160 


Thr Glu Tyr Leu Ala Ile Cys Gly Leu Lys Arg Leu Arg Ile Asn Met 
                165                 170                 175     


Glu Ala Lys His Pro Phe Pro Glu Gln Ser Leu Leu Ile His Ser Gly 
            180                 185                 190         


Gly Asp Ser Asp Ser Arg Glu Lys Pro Met Trp Leu His Lys Gly Trp 
        195                 200                 205             


Gln Pro Cys Met Tyr Ile Ser Phe Leu Asp Met Ala Leu Phe Asn Arg 
    210                 215                 220                 


Asp Ser Ala Leu Lys Ser Tyr Ser Ile Glu Asn Val Thr Ser Ile Ala 
225                 230                 235                 240 


Asn Asn Phe Pro Asp Phe Ser Tyr Phe Arg Thr Phe Pro Met Pro Ser 
                245                 250                 255     


Asn Lys Ser Tyr Val Val Thr Phe Ile Tyr 
            260                 265     


<210>  1869
<211>  219
<212>  PRT
<213>  Homo Sapiens

<400>  1869

Met Ala Pro Pro Ser Arg His Cys Leu Leu Leu Ile Ser Thr Leu Gly 
1               5                   10                  15      


Val Phe Ala Leu Asn Cys Phe Thr Lys Gly Gln Lys Asn Ser Thr Leu 
            20                  25                  30          


Ile Phe Thr Arg Glu Asn Thr Ile Arg Asn Cys Ser Cys Ser Ala Asp 
        35                  40                  45              


Ile Arg Asp Cys Asp Tyr Ser Leu Ala Asn Leu Met Cys Asn Cys Lys 
    50                  55                  60                  


Thr Val Leu Pro Leu Ala Val Glu Arg Thr Ser Tyr Asn Gly His Leu 
65                  70                  75                  80  


Thr Ile Trp Phe Thr Asp Thr Ser Ala Leu Gly His Leu Leu Asn Phe 
                85                  90                  95      


Thr Leu Val Gln Asp Leu Lys Leu Ser Leu Cys Ser Thr Asn Thr Leu 
            100                 105                 110         


Pro Thr Glu Tyr Leu Ala Ile Cys Gly Leu Lys Arg Leu Arg Ile Asn 
        115                 120                 125             


Met Glu Ala Lys His Pro Phe Pro Glu Gln Ser Leu Leu Ile His Ser 
    130                 135                 140                 


Gly Gly Asp Ser Asp Ser Arg Glu Lys Pro Met Trp Leu His Lys Gly 
145                 150                 155                 160 


Trp Gln Pro Cys Met Tyr Ile Ser Phe Leu Asp Met Ala Leu Phe Asn 
                165                 170                 175     


Arg Asp Ser Ala Leu Lys Ser Tyr Ser Ile Glu Asn Val Thr Ser Ile 
            180                 185                 190         


Ala Asn Asn Phe Pro Asp Phe Ser Tyr Phe Arg Thr Phe Pro Met Pro 
        195                 200                 205             


Ser Asn Lys Ser Tyr Val Val Thr Phe Ile Tyr 
    210                 215                 


<210>  1870
<211>  219
<212>  PRT
<213>  Homo Sapiens

<400>  1870

Met Ala Pro Pro Ser Arg His Cys Leu Leu Leu Ile Ser Thr Leu Gly 
1               5                   10                  15      


Val Phe Ala Leu Asn Cys Phe Thr Lys Gly Gln Lys Asn Ser Thr Leu 
            20                  25                  30          


Ile Phe Thr Arg Glu Asn Thr Ile Arg Asn Cys Ser Cys Ser Ala Asp 
        35                  40                  45              


Ile Arg Asp Cys Asp Tyr Ser Leu Ala Asn Leu Met Cys Asn Cys Lys 
    50                  55                  60                  


Thr Val Leu Pro Leu Ala Val Glu Arg Thr Ser Tyr Asn Gly His Leu 
65                  70                  75                  80  


Thr Ile Trp Phe Thr Asp Thr Ser Ala Leu Gly His Leu Leu Asn Phe 
                85                  90                  95      


Thr Leu Val Gln Asp Leu Lys Leu Ser Leu Cys Ser Thr Asn Thr Leu 
            100                 105                 110         


Pro Thr Glu Tyr Leu Ala Ile Cys Gly Leu Lys Arg Leu Arg Ile Asn 
        115                 120                 125             


Met Glu Ala Lys His Pro Phe Pro Glu Gln Ser Leu Leu Ile His Ser 
    130                 135                 140                 


Gly Gly Asp Ser Asp Ser Arg Glu Lys Pro Met Trp Leu His Lys Gly 
145                 150                 155                 160 


Trp Gln Pro Cys Met Tyr Ile Ser Phe Leu Asp Met Ala Leu Phe Asn 
                165                 170                 175     


Arg Asp Ser Ala Leu Lys Ser Tyr Ser Ile Glu Asn Val Thr Ser Ile 
            180                 185                 190         


Ala Asn Asn Phe Pro Asp Phe Ser Tyr Phe Arg Thr Phe Pro Met Pro 
        195                 200                 205             


Ser Asn Lys Ser Tyr Val Val Thr Phe Ile Tyr 
    210                 215                 


<210>  1871
<211>  219
<212>  PRT
<213>  Homo Sapiens

<400>  1871

Met Ala Pro Pro Ser Arg His Cys Leu Leu Leu Ile Ser Thr Leu Gly 
1               5                   10                  15      


Val Phe Ala Leu Asn Cys Phe Thr Lys Gly Gln Lys Asn Ser Thr Leu 
            20                  25                  30          


Ile Phe Thr Arg Glu Asn Thr Ile Arg Asn Cys Ser Cys Ser Ala Asp 
        35                  40                  45              


Ile Arg Asp Cys Asp Tyr Ser Leu Ala Asn Leu Met Cys Asn Cys Lys 
    50                  55                  60                  


Thr Val Leu Pro Leu Ala Val Glu Arg Thr Ser Tyr Asn Gly His Leu 
65                  70                  75                  80  


Thr Ile Trp Phe Thr Asp Thr Ser Ala Leu Gly His Leu Leu Asn Phe 
                85                  90                  95      


Thr Leu Val Gln Asp Leu Lys Leu Ser Leu Cys Ser Thr Asn Thr Leu 
            100                 105                 110         


Pro Thr Glu Tyr Leu Ala Ile Cys Gly Leu Lys Arg Leu Arg Ile Asn 
        115                 120                 125             


Met Glu Ala Lys His Pro Phe Pro Glu Gln Ser Leu Leu Ile His Ser 
    130                 135                 140                 


Gly Gly Asp Ser Asp Ser Arg Glu Lys Pro Met Trp Leu His Lys Gly 
145                 150                 155                 160 


Trp Gln Pro Cys Met Tyr Ile Ser Phe Leu Asp Met Ala Leu Phe Asn 
                165                 170                 175     


Arg Asp Ser Ala Leu Lys Ser Tyr Ser Ile Glu Asn Val Thr Ser Ile 
            180                 185                 190         


Ala Asn Asn Phe Pro Asp Phe Ser Tyr Phe Arg Thr Phe Pro Met Pro 
        195                 200                 205             


Ser Asn Lys Ser Tyr Val Val Thr Phe Ile Tyr 
    210                 215                 


<210>  1872
<211>  148
<212>  PRT
<213>  Homo Sapiens

<400>  1872

Met Phe Ile Lys Val Met Phe Gly Ala Gly Cys Ser Val Leu Val Asn 
1               5                   10                  15      


Thr Ser Cys Arg Leu Val Asn Leu Thr Ala His Leu Arg Gln Lys Ala 
            20                  25                  30          


Gly Leu Pro Pro Asp Ala Thr Ile Ala Leu Leu Ala Glu Asp Gly Asn 
        35                  40                  45              


Leu Val Ser Leu Glu Glu Asp Leu Lys Glu Gly Ala Ser Arg Ala Gln 
    50                  55                  60                  


Thr Met Gly Asn Ser Leu Leu Lys Glu Arg Ala Ile Tyr Val Leu Val 
65                  70                  75                  80  


Arg Ile Ile Lys Gly Glu Asp Met Ala Ser Thr Arg Tyr Glu Ser Leu 
                85                  90                  95      


Leu Glu Asn Leu Asp Asp His Tyr Pro Glu Leu Ala Glu Glu Leu Arg 
            100                 105                 110         


Arg Leu Ser Gly Leu Ser Ser Val Gly His Asn Trp Arg Lys Arg Met 
        115                 120                 125             


Gly Thr Arg Arg Gly Arg His Glu Gln Ser Pro Thr Ser Arg Pro Arg 
    130                 135                 140                 


Lys Gly Pro Asp 
145             


<210>  1873
<211>  157
<212>  PRT
<213>  Homo Sapiens

<400>  1873

Met Phe Ile Lys Val Met Phe Gly Ala Gly Cys Ser Val Leu Val Asn 
1               5                   10                  15      


Thr Ser Cys Arg Leu Val Asn Leu Thr Ala His Leu Arg Gln Lys Ala 
            20                  25                  30          


Gly Leu Pro Pro Asp Ala Thr Ile Ala Leu Leu Ala Glu Asp Gly Asn 
        35                  40                  45              


Leu Val Ser Leu Glu Glu Asp Leu Lys Glu Gly Ala Ser Arg Ala Gln 
    50                  55                  60                  


Thr Met Gly Asn Ser Leu Leu Lys Glu Arg Ala Ile Tyr Val Leu Val 
65                  70                  75                  80  


Arg Ile Ile Ser Lys Arg Glu Arg Thr Trp Pro Pro Pro Ala Met Ser 
                85                  90                  95      


Pro Tyr Trp Arg Thr Trp Met Thr Ile Thr Gln Ser Trp Gln Arg Asn 
            100                 105                 110         


Cys Ala Gly Cys Gln Ala Ser Pro Leu Trp Ala Thr Thr Gly Gly Ser 
        115                 120                 125             


Val Trp Ala Leu Gly Glu Ala Ala Met Ser Lys Ala Pro Leu Gln Gly 
    130                 135                 140                 


Pro Glu Arg Ala Leu Ile Lys Gly Met Asp Cys Thr Leu 
145                 150                 155         


<210>  1874
<211>  142
<212>  PRT
<213>  Homo Sapiens

<400>  1874

Met Phe Ile Lys Val Met Phe Gly Ala Gly Cys Ser Val Leu Val Asn 
1               5                   10                  15      


Thr Ser Cys Arg Leu Val Asn Leu Thr Ala His Leu Arg Gln Lys Ala 
            20                  25                  30          


Gly Leu Pro Pro Asp Ala Thr Ile Ala Leu Leu Ala Glu Asp Gly Asn 
        35                  40                  45              


Leu Val Ser Leu Glu Glu Asp Leu Lys Glu Gly Ala Ser Arg Ala Gln 
    50                  55                  60                  


Thr Met Gly Asn Ser Leu Leu Lys Glu Arg Ala Ile Tyr Val Leu Val 
65                  70                  75                  80  


Arg Ile Ile Ser Lys Val Ala Gln Glu Gly Glu Asp Met Ala Ser Thr 
                85                  90                  95      


Arg Tyr Glu Ser Leu Leu Glu Asn Leu Asp Asp His Tyr Pro Glu Leu 
            100                 105                 110         


Ala Gly Ala Asn Arg Gln Gln Pro Ser Arg Thr Pro Leu Ala Glu Ser 
        115                 120                 125             


Gly Ile Ala Glu Lys Leu His Gln Gln Glu Gly Gln Gly Pro 
    130                 135                 140         


<210>  1875
<211>  243
<212>  PRT
<213>  Homo Sapiens

<400>  1875

Met Leu Leu Ser Leu Leu Gly Ala Cys Ala Val Val Gly Pro Phe His 
1               5                   10                  15      


Gly Pro Glu Trp Glu Pro Val Gln Gly Leu Leu Ser Gln Asn His Ser 
            20                  25                  30          


Cys Arg Asp Pro Gln Cys Cys Gly Asn Leu Leu Val Leu Cys Leu Phe 
        35                  40                  45              


Leu Val Trp Gln Val Arg His Cys Trp His Gln Val Thr Arg Thr Arg 
    50                  55                  60                  


Phe Ser Thr Arg Asn Val Ile Lys Val Pro Leu Gln Lys Arg Ala Val 
65                  70                  75                  80  


Pro Ser Met Arg Cys Glu Thr Val Phe Lys Leu Thr Pro Glu Phe Phe 
                85                  90                  95      


Ser Pro Gly Lys Ser Arg Gly Leu Asp Ser Gln Gln Cys Ala Gln Arg 
            100                 105                 110         


Gln Arg Trp Gly Tyr Arg Arg Ser Leu Gln Glu Ser Trp Ala Gln Asn 
        115                 120                 125             


Leu Leu Ser Pro Gln His Pro Cys Pro Gly Pro Pro Ser Gly Val His 
    130                 135                 140                 


Thr His Ser Glu Pro Ile Phe Cys Thr Thr Ser Ile Ser Asn Thr Cys 
145                 150                 155                 160 


Leu Leu Pro Gln Asn Ser Ser Trp Lys Ala Trp Gln Val Pro Trp Cys 
                165                 170                 175     


Leu His Asp Gly Gln Thr Arg Pro Ala Leu Asp Met Cys Gln Glu Met 
            180                 185                 190         


Glu Gln Leu Leu Leu His Ser Gln Glu Arg Leu Val Ser Leu Glu Pro 
        195                 200                 205             


Val Ile Ser Val Arg Ser Arg Pro Thr Ser Met Thr Leu Thr Thr Ser 
    210                 215                 220                 


Leu Pro Asn Leu Leu Ser Ala Glu Arg Leu Gln Phe Cys Pro Gln Arg 
225                 230                 235                 240 


Ala Pro Ala 
            


<210>  1876
<211>  696
<212>  PRT
<213>  Homo Sapiens

<400>  1876

Met Ala Met Ala Arg Leu Gly Ser Trp Leu Gly Glu Ala Gln Trp Leu 
1               5                   10                  15      


Ala Leu Val Ser Leu Phe Val Ala Ala Leu Ala Thr Val Gly Leu Tyr 
            20                  25                  30          


Leu Ala Gln Trp Ala Leu Ala Arg Ala Arg Pro Gln Pro Gln Arg Arg 
        35                  40                  45              


Ala Val Glu Pro Gly Glu Gly Pro Arg Pro Gly Ser Asp Ala Leu Leu 
    50                  55                  60                  


Ser Trp Ile Leu Thr Leu Gly Ser Trp Arg Ser Gln Trp Gln Ala Ala 
65                  70                  75                  80  


Trp Val Thr Ala Leu Asn Glu Glu Ala Glu Arg Lys Gly Gly Pro Pro 
                85                  90                  95      


Phe Leu Ser Phe Glu Glu Asp Pro Arg Gln Gln Ala Leu Glu Leu Val 
            100                 105                 110         


Val Gln Glu Val Ser Ser Val Leu Arg Ser Ala Glu Glu Lys Val Val 
        115                 120                 125             


Val Cys His Val Val Gly Gln Ala Ile Gln Phe Leu Val Ser Glu Thr 
    130                 135                 140                 


Pro Ala Leu Gly Ala Gly Cys Arg Leu Tyr Asp Met Arg Leu Ser Pro 
145                 150                 155                 160 


Phe His Leu Gln Leu Glu Phe His Met Lys Glu Lys Arg Glu Asp Leu 
                165                 170                 175     


Gln Ile Ser Trp Ser Phe Ile Ser Val Pro Glu Met Ala Val Asn Ile 
            180                 185                 190         


Gln Pro Lys Ala Leu Gly Glu Asp Gln Val Ala Glu Thr Ser Ala Met 
        195                 200                 205             


Ser Asp Val Leu Lys Asp Ile Leu Lys His Leu Ala Gly Ser Ala Ser 
    210                 215                 220                 


Pro Ser Val Val Leu Ile Thr Lys Pro Thr Thr Val Lys Glu Ala Gln 
225                 230                 235                 240 


Asn Leu Gln Cys Ala Ala Ser Thr Ala Gln Glu Ser Cys Pro Pro Lys 
                245                 250                 255     


Pro Pro Arg Ala His Glu Leu Lys Leu Leu Val Arg Asn Ile His Val 
            260                 265                 270         


Leu Leu Leu Ser Glu Pro Gly Ala Ser Gly His Ile Asn Ala Val Cys 
        275                 280                 285             


Val Val Gln Leu Asn Asp Pro Val Gln Arg Phe Ser Ser Thr Leu Thr 
    290                 295                 300                 


Lys Asn Thr Pro Asp Leu Met Trp Glu Glu Glu Phe Thr Phe Glu Leu 
305                 310                 315                 320 


Asn Ala Lys Ser Lys Glu Leu His Leu Gln Ile Ser Glu Ala Gly Arg 
                325                 330                 335     


Ser Ser Glu Gly Leu Leu Ala Thr Ala Thr Val Pro Leu Asp Leu Phe 
            340                 345                 350         


Lys Lys Gln Pro Ser Gly Pro Gln Ser Phe Thr Leu Thr Ser Gly Ser 
        355                 360                 365             


Ala Cys Gly Ser Ser Val Leu Gly Ser Val Thr Ala Glu Phe Ser Tyr 
    370                 375                 380                 


Met Glu Pro Gly Glu Leu Lys Ser Trp Pro Ile Pro Pro Pro Val Pro 
385                 390                 395                 400 


Ala Ala Lys Ile Glu Lys Asp Arg Thr Val Met Pro Cys Gly Thr Val 
                405                 410                 415     


Val Thr Thr Val Thr Ala Val Lys Thr Lys Pro Arg Val Asp Val Gly 
            420                 425                 430         


Arg Ala Ser Pro Leu Ser Ser Asp Ser Pro Val Lys Thr Pro Ile Lys 
        435                 440                 445             


Val Lys Val Ile Glu Lys Asp Ile Ser Val Gln Ala Ile Ala Cys Arg 
    450                 455                 460                 


Ser Ala Pro Val Ser Lys Thr Leu Ser Ser Ser Asp Thr Glu Leu Leu 
465                 470                 475                 480 


Val Leu Asn Gly Ser Asp Pro Val Ala Glu Val Ala Ile Arg Gln Leu 
                485                 490                 495     


Ser Glu Ser Ser Lys Leu Lys Leu Lys Ser Pro Arg Lys Lys Ser Thr 
            500                 505                 510         


Ile Ile Ile Ser Gly Ile Ser Lys Thr Ser Leu Ser Gln Asp His Asp 
        515                 520                 525             


Ala Ala Leu Met Gln Gly Tyr Thr Ala Ser Val Asp Ser Thr His Gln 
    530                 535                 540                 


Glu Asp Ala Pro Ser His Pro Glu Arg Ala Ala Ala Ser Ala Pro Pro 
545                 550                 555                 560 


Glu Glu Ala Glu Ser Ala Gln Ala Ser Leu Ala Pro Lys Pro Gln Glu 
                565                 570                 575     


Asp Glu Leu Asp Ser Trp Asp Leu Glu Lys Glu Pro Gln Ala Ala Ala 
            580                 585                 590         


Trp Ser Ser Gln Val Leu Leu Asp Pro Asp Gly Asp Glu Leu Ser Glu 
        595                 600                 605             


Ser Ser Met Ser Val Leu Glu Pro Gly Thr Ala Lys Lys His Lys Gly 
    610                 615                 620                 


Gly Ile Leu Arg Lys Gly Ala Lys Leu Phe Phe Arg Arg Arg His Gln 
625                 630                 635                 640 


Gln Lys Asp Pro Gly Met Ser Gln Ser His Asn Asp Leu Val Phe Leu 
                645                 650                 655     


Glu Gln Pro Glu Gly Ser Arg Arg Lys Gly Ile Thr Leu Thr Arg Ile 
            660                 665                 670         


Leu Asn Lys Lys Leu Leu Ser Arg His Arg Asn Lys Asn Thr Met Asn 
        675                 680                 685             


Gly Ala Pro Val Glu Pro Cys Thr 
    690                 695     


<210>  1877
<211>  541
<212>  PRT
<213>  Homo Sapiens

<400>  1877

Met Arg Leu Ser Pro Phe His Leu Gln Leu Glu Phe His Met Lys Glu 
1               5                   10                  15      


Lys Arg Glu Asp Leu Gln Ile Ser Trp Ser Phe Ile Ser Val Pro Glu 
            20                  25                  30          


Met Ala Val Asn Ile Gln Pro Lys Ala Leu Gly Glu Asp Gln Val Ala 
        35                  40                  45              


Glu Thr Ser Ala Met Ser Asp Val Leu Lys Asp Ile Leu Lys His Leu 
    50                  55                  60                  


Ala Gly Ser Ala Ser Pro Ser Val Val Leu Ile Thr Lys Pro Thr Thr 
65                  70                  75                  80  


Val Lys Glu Ala Gln Asn Leu Gln Cys Ala Ala Ser Thr Ala Gln Glu 
                85                  90                  95      


Ser Cys Pro Pro Lys Pro Pro Arg Ala His Glu Leu Lys Leu Leu Val 
            100                 105                 110         


Arg Asn Ile His Val Leu Leu Leu Ser Glu Pro Gly Ala Ser Gly His 
        115                 120                 125             


Ile Asn Ala Val Cys Val Val Gln Leu Asn Asp Pro Val Gln Arg Phe 
    130                 135                 140                 


Ser Ser Thr Leu Thr Lys Asn Thr Pro Asp Leu Met Trp Glu Glu Glu 
145                 150                 155                 160 


Phe Thr Phe Glu Leu Asn Ala Lys Ser Lys Glu Leu His Leu Gln Ile 
                165                 170                 175     


Ser Glu Ala Gly Arg Ser Ser Glu Gly Leu Leu Ala Thr Ala Thr Val 
            180                 185                 190         


Pro Leu Asp Leu Phe Lys Lys Gln Pro Ser Gly Pro Gln Ser Phe Thr 
        195                 200                 205             


Leu Thr Ser Gly Ser Ala Cys Gly Ser Ser Val Leu Gly Ser Val Thr 
    210                 215                 220                 


Ala Glu Phe Ser Tyr Met Glu Pro Gly Glu Leu Lys Ser Trp Pro Ile 
225                 230                 235                 240 


Pro Pro Pro Val Pro Ala Ala Lys Ile Glu Lys Asp Arg Thr Val Met 
                245                 250                 255     


Pro Cys Gly Thr Val Val Thr Thr Val Thr Ala Val Lys Thr Lys Pro 
            260                 265                 270         


Arg Val Asp Val Gly Arg Ala Ser Pro Leu Ser Ser Asp Ser Pro Val 
        275                 280                 285             


Lys Thr Pro Ile Lys Val Lys Val Ile Glu Lys Asp Ile Ser Val Gln 
    290                 295                 300                 


Ala Ile Ala Cys Arg Ser Ala Pro Val Ser Lys Thr Leu Ser Ser Ser 
305                 310                 315                 320 


Asp Thr Glu Leu Leu Val Leu Asn Gly Ser Asp Pro Val Ala Glu Val 
                325                 330                 335     


Ala Ile Arg Gln Leu Ser Glu Ser Ser Lys Leu Lys Leu Lys Ser Pro 
            340                 345                 350         


Arg Lys Lys Ser Thr Ile Ile Ile Ser Gly Ile Ser Lys Thr Ser Leu 
        355                 360                 365             


Ser Gln Asp His Asp Ala Ala Leu Met Gln Gly Tyr Thr Ala Ser Val 
    370                 375                 380                 


Asp Ser Thr His Gln Glu Asp Ala Pro Ser His Pro Glu Arg Ala Ala 
385                 390                 395                 400 


Ala Ser Ala Pro Pro Glu Glu Ala Glu Ser Ala Gln Ala Ser Leu Ala 
                405                 410                 415     


Pro Lys Pro Gln Glu Asp Glu Leu Asp Ser Trp Asp Leu Glu Lys Glu 
            420                 425                 430         


Pro Gln Ala Ala Ala Trp Ser Ser Gln Val Leu Leu Asp Pro Asp Gly 
        435                 440                 445             


Asp Glu Leu Ser Glu Ser Ser Met Ser Val Leu Glu Pro Gly Thr Ala 
    450                 455                 460                 


Lys Lys His Lys Gly Gly Ile Leu Arg Lys Gly Ala Lys Leu Phe Phe 
465                 470                 475                 480 


Arg Arg Arg His Gln Gln Lys Asp Pro Gly Met Ser Gln Ser His Asn 
                485                 490                 495     


Asp Leu Val Phe Leu Glu Gln Pro Glu Gly Ser Arg Arg Lys Gly Ile 
            500                 505                 510         


Thr Leu Thr Arg Ile Leu Asn Lys Lys Leu Leu Ser Arg His Arg Asn 
        515                 520                 525             


Lys Asn Thr Met Asn Gly Ala Pro Val Glu Pro Cys Thr 
    530                 535                 540     


<210>  1878
<211>  182
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1878

Xaa Ser Thr Ile Ile Ile Ser Gly Ile Ser Lys Asp His Asp Ala Ala 
1               5                   10                  15      


Leu Met Gln Gly Tyr Thr Ala Ser Val Asp Ser Thr His Gln Glu Asp 
            20                  25                  30          


Ala Pro Ser His Pro Glu Arg Ala Ala Ala Ser Ala Pro Pro Glu Glu 
        35                  40                  45              


Ala Glu Ser Ala Gln Ala Ser Leu Ala Pro Lys Pro Gln Glu Asp Glu 
    50                  55                  60                  


Leu Asp Ser Trp Asp Leu Glu Lys Glu Pro Gln Ala Ala Ala Trp Ser 
65                  70                  75                  80  


Ser Gln Val Leu Leu Asp Pro Asp Gly Asp Glu Leu Ser Glu Ser Ser 
                85                  90                  95      


Met Ser Val Leu Glu Pro Gly Thr Ala Lys Lys His Lys Gly Gly Ile 
            100                 105                 110         


Leu Arg Lys Gly Ala Lys Leu Phe Phe Arg Arg Arg His Gln Gln Lys 
        115                 120                 125             


Asp Pro Gly Met Ser Gln Ser His Asn Asp Leu Val Phe Leu Glu Gln 
    130                 135                 140                 


Pro Glu Gly Ser Arg Arg Lys Gly Ile Thr Leu Thr Arg Ile Leu Asn 
145                 150                 155                 160 


Lys Lys Leu Leu Ser Arg His Arg Asn Lys Asn Thr Met Asn Gly Ala 
                165                 170                 175     


Pro Val Glu Pro Cys Thr 
            180         


<210>  1879
<211>  148
<212>  PRT
<213>  Homo Sapiens

<400>  1879

Met Ala Ala Ser Pro Ala Arg Pro Ala Val Leu Ala Leu Thr Gly Leu 
1               5                   10                  15      


Ala Leu Leu Leu Leu Leu Cys Trp Gly Pro Gly Gly Ile Ser Gly Asn 
            20                  25                  30          


Lys Leu Lys Leu Met Leu Gln Lys Arg Glu Ala Pro Val Pro Thr Lys 
        35                  40                  45              


Thr Lys Val Ala Val Asp Glu Asn Lys Ala Lys Glu Phe Leu Gly Ser 
    50                  55                  60                  


Leu Lys Arg Gln Lys Arg Gln Leu Trp Asp Arg Thr Arg Pro Glu Val 
65                  70                  75                  80  


Gln Gln Trp Tyr Gln Gln Phe Leu Tyr Met Gly Phe Asp Glu Ala Lys 
                85                  90                  95      


Phe Glu Asp Asp Ile Thr Tyr Trp Leu Asn Arg Asp Arg Asn Gly His 
            100                 105                 110         


Glu Tyr Tyr Gly Asp Tyr Tyr Gln Arg His Tyr Asp Glu Asp Ser Ala 
        115                 120                 125             


Ile Gly Pro Arg Ser Pro Tyr Gly Phe Arg His Gly Ala Ser Val Asn 
    130                 135                 140                 


Tyr Asp Asp Tyr 
145             


<210>  1880
<211>  112
<212>  PRT
<213>  Homo Sapiens

<400>  1880

Met Leu Gln Lys Arg Glu Ala Pro Val Pro Thr Lys Thr Lys Val Ala 
1               5                   10                  15      


Val Asp Glu Asn Lys Ala Lys Glu Phe Leu Gly Ser Leu Lys Arg Gln 
            20                  25                  30          


Lys Arg Gln Leu Trp Asp Arg Thr Arg Pro Glu Val Gln Gln Trp Tyr 
        35                  40                  45              


Gln Gln Phe Leu Tyr Met Gly Phe Asp Glu Ala Lys Phe Glu Asp Asp 
    50                  55                  60                  


Ile Thr Tyr Trp Leu Asn Arg Asp Arg Asn Gly His Glu Tyr Tyr Gly 
65                  70                  75                  80  


Asp Tyr Tyr Gln Arg His Tyr Asp Glu Asp Ser Ala Ile Gly Pro Arg 
                85                  90                  95      


Ser Pro Tyr Gly Phe Arg His Gly Ala Ser Val Asn Tyr Asp Asp Tyr 
            100                 105                 110         


<210>  1881
<211>  142
<212>  PRT
<213>  Homo Sapiens

<400>  1881

Met Gln Gln Leu Arg Val Arg Gly Ser Tyr Arg Ser Ala Ser Gln Phe 
1               5                   10                  15      


Ala Gly Trp Arg Arg Val Phe Tyr Gln Ala Arg Gln Gly Gly Ile Ser 
            20                  25                  30          


Gly Asn Lys Leu Lys Leu Met Leu Gln Lys Arg Glu Ala Pro Val Pro 
        35                  40                  45              


Thr Lys Thr Lys Val Ala Val Asp Glu Asn Lys Ala Lys Glu Phe Leu 
    50                  55                  60                  


Gly Ser Leu Lys Arg Gln Lys Arg Gln Leu Trp Asp Arg Thr Arg Pro 
65                  70                  75                  80  


Glu Val Gln Gln Trp Tyr Gln Gln Phe Leu Tyr Met Gly Phe Asp Glu 
                85                  90                  95      


Ala Lys Phe Glu Asp Asp Ile Thr Tyr Trp Leu Asn Arg Asp Arg Asn 
            100                 105                 110         


Gly His Glu Tyr Tyr Gly Asp Tyr Tyr Gln Arg His Tyr Asp Glu Asp 
        115                 120                 125             


Ser Ala Ile Gly Pro Arg Ser Pro Tyr Gly Phe Arg His Gly 
    130                 135                 140         


<210>  1882
<211>  117
<212>  PRT
<213>  Homo Sapiens

<400>  1882

Met Ile Ile Asp Ser Ser Arg Ile Pro Ser Phe Thr Gln Leu His Ser 
1               5                   10                  15      


Thr Met Thr Arg Ala Pro Leu Leu Leu Leu Cys Val Ala Leu Val Leu 
            20                  25                  30          


Leu Gly His Val Asn Gly Ala Thr Val Arg Asn Glu Asp Lys Trp Lys 
        35                  40                  45              


Pro Leu Asn Asn Pro Arg Asn Arg Asp Leu Phe Phe Arg Arg Leu Gln 
    50                  55                  60                  


Ala Tyr Phe Lys Gly Arg Gly Leu Asp Leu Gly Thr Phe Pro Asn Pro 
65                  70                  75                  80  


Phe Pro Thr Asn Glu Asn Pro Arg Pro Leu Ser Phe Gln Ser Glu Leu 
                85                  90                  95      


Thr Ala Ser Ala Ser Ala Asp Tyr Glu Glu Gln Lys Asn Ser Phe His 
            100                 105                 110         


Asn Tyr Leu Lys Gly 
        115         


<210>  1883
<211>  385
<212>  PRT
<213>  Homo Sapiens

<400>  1883

Met Trp Gly Phe Arg Leu Leu Arg Ser Pro Pro Leu Leu Leu Leu Leu 
1               5                   10                  15      


Pro Gln Leu Gly Ile Gly Asn Ala Ser Ser Cys Ser Gln Ala Arg Thr 
            20                  25                  30          


Met Asn Pro Gly Gly Ser Gly Gly Ala Arg Cys Ser Leu Ser Ala Glu 
        35                  40                  45              


Val Arg Arg Arg Gln Cys Leu Gln Leu Ser Thr Val Pro Gly Ala Asp 
    50                  55                  60                  


Pro Gln Arg Ser Asn Glu Leu Leu Leu Leu Ala Ala Ala Gly Glu Gly 
65                  70                  75                  80  


Leu Glu Arg Gln Asp Leu Pro Gly Asp Pro Ala Lys Glu Glu Pro Gln 
                85                  90                  95      


Pro Pro Pro Gln His His Val Leu Tyr Phe Pro Gly Asp Val Gln Asn 
            100                 105                 110         


Tyr His Glu Ile Met Thr Arg His Pro Glu Asn Tyr Gln Trp Glu Asn 
        115                 120                 125             


Trp Ser Leu Glu Asn Val Ala Thr Ile Leu Ala His Arg Phe Pro Asn 
    130                 135                 140                 


Ser Tyr Ile Trp Val Ile Lys Cys Ser Arg Met His Leu His Lys Phe 
145                 150                 155                 160 


Ser Cys Tyr Asp Asn Phe Val Lys Ser Asn Met Phe Gly Ala Pro Glu 
                165                 170                 175     


His Asn Thr Asp Phe Gly Ala Phe Lys His Leu Tyr Met Leu Leu Val 
            180                 185                 190         


Asn Ala Phe Asn Leu Ser Gln Asn Ser Leu Ser Lys Lys Ser Leu Asn 
        195                 200                 205             


Val Trp Asn Lys Asp Ser Ile Ala Ser Asn Cys Arg Ser Ser Pro Ser 
    210                 215                 220                 


His Thr Thr Asn Gly Cys Gln Gly Glu Lys Val Arg Thr Cys Glu Lys 
225                 230                 235                 240 


Ser Asp Glu Ser Ala Met Ser Phe Tyr Pro Pro Ser Leu Asn Asp Ala 
                245                 250                 255     


Ser Phe Thr Leu Ile Gly Phe Ser Lys Gly Cys Val Val Leu Asn Gln 
            260                 265                 270         


Leu Leu Phe Glu Leu Lys Glu Ala Lys Lys Asp Lys Asn Ile Asp Ala 
        275                 280                 285             


Phe Ile Lys Ser Ile Arg Thr Met Tyr Trp Leu Asp Gly Gly His Ser 
    290                 295                 300                 


Gly Gly Ser Asn Thr Trp Val Thr Tyr Pro Glu Val Leu Lys Glu Phe 
305                 310                 315                 320 


Ala Gln Thr Gly Ile Ile Val His Thr His Val Thr Pro Tyr Gln Val 
                325                 330                 335     


Arg Asp Pro Met Arg Ser Trp Ile Gly Lys Glu His Lys Lys Phe Val 
            340                 345                 350         


Gln Ile Leu Gly Asp Leu Gly Met Gln Val Thr Ser Gln Ile His Phe 
        355                 360                 365             


Thr Lys Glu Ala Pro Ser Ile Glu Asn His Phe Arg Val His Glu Val 
    370                 375                 380                 


Phe 
385 


<210>  1884
<211>  922
<212>  PRT
<213>  Homo Sapiens

<400>  1884

Met His Trp Leu Ala Ser Ala Thr Gln Thr Ser Ala Ser Ile Val Ser 
1               5                   10                  15      


Ser Ser Leu Leu Ser Ala Val Asp Val Ser Ser Ser Leu Thr Met Ser 
            20                  25                  30          


Glu Tyr Phe Gln Asn Thr Ser Leu Pro Gly Thr Ala Asn Ser Arg Gln 
        35                  40                  45              


Phe Ser Leu Pro Val Val Ser Asn Ala Ala Phe Leu Thr Gly Ser Ile 
    50                  55                  60                  


Ser Asn Phe Ser Arg Ala Ser Ala Pro Ala Ile Ser Ser Ala Trp Leu 
65                  70                  75                  80  


Gln Pro Ser Ala Ser Gly Thr Ser Phe Gln Pro Leu Met Gly Ser Ala 
                85                  90                  95      


Tyr Leu Tyr Gln His Ser Ser Thr Thr Met Leu Ser Gly Val Thr Gly 
            100                 105                 110         


Gln Ser His Ile Cys Thr Ser Ala Ala Ser Tyr Pro Gly Val Phe Glu 
        115                 120                 125             


Trp Asp Ser Thr Ala Ser Thr Val Lys Lys Ser Ser Ser Leu Arg Asp 
    130                 135                 140                 


Phe Thr Val Thr Val Ile Asp Gln Asn Thr Ala Val Ser Ser Met Ser 
145                 150                 155                 160 


Met Thr Ala Gln Tyr Tyr Lys Thr Ser Asp Thr Asn Thr Met Val Pro 
                165                 170                 175     


Leu Tyr Pro Ser Leu Ser Ala Ser Leu Val Gln Gly Thr Leu Thr Gln 
            180                 185                 190         


Ile Pro Asn Gln Gln Gly His Asn Leu Ser Leu Pro Cys Gln Ile Gly 
        195                 200                 205             


Ser Gln Val Tyr Tyr Tyr Asn Gln Gly Thr Leu Gly Pro Gln Leu Ser 
    210                 215                 220                 


Cys Leu Gln Ser Tyr Gly Ser Val Ser Tyr Thr Gly Tyr Arg Ala Ser 
225                 230                 235                 240 


Ala His Gln Pro Glu Met Val Met Val Leu Lys Glu Val Gln Pro Thr 
                245                 250                 255     


Asn Val Leu Pro Pro Val Ser Thr Ser Gly Met Tyr Tyr Ser Val Ser 
            260                 265                 270         


Ser Gln Pro Ile Thr Glu Thr Ser Val Gln Val Met Glu Thr Ser Leu 
        275                 280                 285             


Gly Met Asp Thr Ser Leu Gly Leu Gln Ser Pro Ser Gln Thr Phe Cys 
    290                 295                 300                 


Leu Pro Gln Thr Pro Glu Phe Ser Lys Ser Phe Ser Ser Arg Asn Thr 
305                 310                 315                 320 


Gln Thr Leu Glu Ser Asn Pro Ser Pro Glu Leu Gly Asp Ile Ser Ile 
                325                 330                 335     


Thr Pro Val Gln Ser Pro Thr Asn Leu Leu Thr Leu Ser Pro Ala Pro 
            340                 345                 350         


Ser Gln Glu Lys Asn Glu Asn Glu Asn Leu Asp Glu Ile Lys Thr Asn 
        355                 360                 365             


Leu Ser Lys Pro Leu Asp Val His Gln Ile Leu Ile Gly Asn Gln Asp 
    370                 375                 380                 


Pro Pro Leu Leu Pro Val Glu Ile Pro Asp Ile His Pro Leu Leu Ala 
385                 390                 395                 400 


Cys Ile Asp Pro Leu Gly Gln Glu Glu Gln Pro Gly Ser Glu Asn Ala 
                405                 410                 415     


Asn Leu Arg Asn Lys Ser Leu Ser Leu Glu Asp Gln Gly Ile Phe Glu 
            420                 425                 430         


Asn Gly Ile Glu Ser Ser Ser Asp Leu Ala Asp Ile Thr Thr Trp Val 
        435                 440                 445             


Glu Asp Thr Tyr Leu Pro Pro Ile Phe Ser Ser Leu Gln Asp Leu Asp 
    450                 455                 460                 


Gln Pro Glu Ser Pro Ser Ala Lys Lys Ala Lys Asp Thr Ser Ala Ile 
465                 470                 475                 480 


Lys Val Asn Gln Val Gln Glu Lys Ser Cys Val Ile Lys Gly His Ser 
                485                 490                 495     


Asp Gln Val Arg Lys Asn Lys His Lys Ala Ser Glu Pro Ile Gln Gly 
            500                 505                 510         


Ala Pro Lys Ala Lys Ile Gln Pro Lys Asn Pro Glu Cys Leu Leu Glu 
        515                 520                 525             


Arg Glu Val Val Val Gly Ser Ala Thr Val Ser Asn Ser Ala Ser Val 
    530                 535                 540                 


Asn Lys Ala Lys His Ser Ser Asn Lys Pro His Lys Ala Ala Ser Ser 
545                 550                 555                 560 


Arg Ile Ser Lys Thr Lys Ser His Gly Gln Glu Lys Thr Lys Gly Asn 
                565                 570                 575     


Arg Lys Asn Ser Ser Lys Lys Ser Glu Glu Ser Lys Gln Ser Gly Lys 
            580                 585                 590         


Lys Val Lys Val Glu Glu Lys Gln Thr Ile Pro Asn Met Lys Arg Lys 
        595                 600                 605             


Lys Asn Gln Pro Glu Leu Ser Gln Lys Thr Leu Lys Lys Pro Arg Ser 
    610                 615                 620                 


Ser Leu Gly Met His Met Leu Glu Ser Val Gln Val Phe His Ala Leu 
625                 630                 635                 640 


Gly Lys Lys Ile Asp Met Lys Thr Gly Phe Ser Ser Ser Arg Thr Leu 
                645                 650                 655     


Gly Ser Ser Ser Asn Thr Gln Asn Arg Gln Pro Phe Pro Ala Leu Lys 
            660                 665                 670         


Pro Trp Leu Asp Ile Gln His Glu Gly Lys Gly Pro Glu Lys Ile Gln 
        675                 680                 685             


Val Lys Ala Gln Lys Leu Asp Gly Ser Ala Glu Lys Glu Cys Thr Ser 
    690                 695                 700                 


Pro Ser His Ser Glu Leu Pro Pro Pro Gly Lys Val Lys Leu Ile Pro 
705                 710                 715                 720 


Leu Pro Phe Leu Thr Leu Asp Gln Pro Gln Ala Arg His Val Ser Arg 
                725                 730                 735     


Arg Pro Asn Pro Leu Ala Ser Arg Arg Pro Ala Val Ala Tyr Pro Ala 
            740                 745                 750         


Arg Pro Asp Ser Thr Asn Ser Ala Gln Ser Asn Ala Val Asn Pro Ser 
        755                 760                 765             


Arg Pro Ala Pro Thr Asn Thr Ser Leu Thr Gly Pro Ala Thr Pro Ala 
    770                 775                 780                 


Gln Pro Ile Ser Ala Lys Ala Thr Gln Pro Ser Ser Ala Asn Pro Thr 
785                 790                 795                 800 


Gln Pro Thr Val Pro Gln Ser Ala Ala Ser Arg Pro Ser Ala Tyr Lys 
                805                 810                 815     


Thr Ser Ser Cys Ser Ser Leu Gln Arg Glu Pro Val Ser Thr Ala Val 
            820                 825                 830         


Thr Ser Leu Arg Ser Leu Pro Lys Pro Gln Asn Gln Phe Leu Ile Gln 
        835                 840                 845             


Asp Phe Ser Leu Gln Pro Arg Pro Trp Arg Lys Pro Thr Val Pro Glu 
    850                 855                 860                 


Pro Val Met Ser Thr Pro Ile Thr Glu Glu Gln Arg Pro Glu Arg Glu 
865                 870                 875                 880 


Ala Met Lys Arg Lys Ala Gln Gln Glu Arg Glu Asn Ala Ala Lys Tyr 
                885                 890                 895     


Thr Ser Leu Gly Lys Val Gln Phe Phe Ile Glu Arg Glu Arg Asp Met 
            900                 905                 910         


Glu Ile Ala Glu Tyr Tyr Gly Tyr Thr Ile 
        915                 920         


<210>  1885
<211>  192
<212>  PRT
<213>  Homo Sapiens

<400>  1885

Ile Thr His Arg Ile His Trp Glu Ser Ala Ser Leu Leu Arg Ser Glu 
1               5                   10                  15      


Glu Thr Lys Glu Asn Glu Gly Phe Thr Val Thr Ala Glu Gly Lys Gly 
            20                  25                  30          


Gln Gly Thr Leu Ser Val Val Thr Met Tyr His Ala Lys Ala Lys Asp 
        35                  40                  45              


Gln Leu Thr Cys Asn Lys Phe Asp Leu Lys Val Thr Ile Lys Pro Ala 
    50                  55                  60                  


Pro Glu Thr Gly Ile Pro Ser Pro Ile Phe Leu Ser Ser Val Phe Leu 
65                  70                  75                  80  


Glu Lys Arg Pro Gln Asp Ala Lys Asn Thr Met Ile Leu Glu Ile Cys 
                85                  90                  95      


Thr Arg Tyr Arg Gly Asp Gln Asp Ala Thr Met Ser Ile Leu Asp Ile 
            100                 105                 110         


Ser Met Met Thr Gly Phe Ala Pro Asp Thr Asp Asp Leu Lys Gln Leu 
        115                 120                 125             


Ala Asn Gly Val Asp Arg Tyr Ile Ser Lys Tyr Glu Leu Asp Lys Ala 
    130                 135                 140                 


Phe Ser Asp Arg Asn Thr Leu Ile Ile Tyr Leu Asp Lys Val Ser His 
145                 150                 155                 160 


Ser Glu Asp Asp Cys Leu Ala Phe Lys Val His Gln Tyr Phe Asn Val 
                165                 170                 175     


Glu Leu Ile Gln Pro Gly Ala Val Lys Val Tyr Ala Tyr Tyr Asn Leu 
            180                 185                 190         


<210>  1886
<211>  1663
<212>  PRT
<213>  Homo Sapiens

<400>  1886

Met Gly Pro Thr Ser Gly Pro Ser Leu Leu Leu Leu Leu Leu Thr His 
1               5                   10                  15      


Leu Pro Leu Ala Leu Gly Ser Pro Met Tyr Ser Ile Ile Thr Pro Asn 
            20                  25                  30          


Ile Leu Arg Leu Glu Ser Glu Glu Thr Met Val Leu Glu Ala His Asp 
        35                  40                  45              


Ala Gln Gly Asp Val Pro Val Thr Val Thr Val His Asp Phe Pro Gly 
    50                  55                  60                  


Lys Lys Leu Val Leu Ser Ser Glu Lys Thr Val Leu Thr Pro Ala Thr 
65                  70                  75                  80  


Asn His Met Gly Asn Val Thr Phe Thr Ile Pro Ala Asn Arg Glu Phe 
                85                  90                  95      


Lys Ser Glu Lys Gly Arg Asn Lys Phe Val Thr Val Gln Ala Thr Phe 
            100                 105                 110         


Gly Thr Gln Val Val Glu Lys Val Val Leu Val Ser Leu Gln Ser Gly 
        115                 120                 125             


Tyr Leu Phe Ile Gln Thr Asp Lys Thr Ile Tyr Thr Pro Gly Ser Thr 
    130                 135                 140                 


Val Leu Tyr Arg Ile Phe Thr Val Asn His Lys Leu Leu Pro Val Gly 
145                 150                 155                 160 


Arg Thr Val Met Val Asn Ile Glu Asn Pro Glu Gly Ile Pro Val Lys 
                165                 170                 175     


Gln Asp Ser Leu Ser Ser Gln Asn Gln Leu Gly Val Leu Pro Leu Ser 
            180                 185                 190         


Trp Asp Ile Pro Glu Leu Val Asn Met Gly Gln Trp Lys Ile Arg Ala 
        195                 200                 205             


Tyr Tyr Glu Asn Ser Pro Gln Gln Val Phe Ser Thr Glu Phe Glu Val 
    210                 215                 220                 


Lys Glu Tyr Val Leu Pro Ser Phe Glu Val Ile Val Glu Pro Thr Glu 
225                 230                 235                 240 


Lys Phe Tyr Tyr Ile Tyr Asn Glu Lys Gly Leu Glu Val Thr Ile Thr 
                245                 250                 255     


Ala Arg Phe Leu Tyr Gly Lys Lys Val Glu Gly Thr Ala Phe Val Ile 
            260                 265                 270         


Phe Gly Ile Gln Asp Gly Glu Gln Arg Ile Ser Leu Pro Glu Ser Leu 
        275                 280                 285             


Lys Arg Ile Pro Ile Glu Asp Gly Ser Gly Glu Val Val Leu Ser Arg 
    290                 295                 300                 


Lys Val Leu Leu Asp Gly Val Gln Asn Pro Arg Ala Glu Asp Leu Val 
305                 310                 315                 320 


Gly Lys Ser Leu Tyr Val Ser Ala Thr Val Ile Leu His Ser Gly Ser 
                325                 330                 335     


Asp Met Val Gln Ala Glu Arg Ser Gly Ile Pro Ile Val Thr Ser Pro 
            340                 345                 350         


Tyr Gln Ile His Phe Thr Lys Thr Pro Lys Tyr Phe Lys Pro Gly Met 
        355                 360                 365             


Pro Phe Asp Leu Met Val Phe Val Thr Asn Pro Asp Gly Ser Pro Ala 
    370                 375                 380                 


Tyr Arg Val Pro Val Ala Val Gln Gly Glu Asp Thr Val Gln Ser Leu 
385                 390                 395                 400 


Thr Gln Gly Asp Gly Val Ala Lys Leu Ser Ile Asn Thr His Pro Ser 
                405                 410                 415     


Gln Lys Pro Leu Ser Ile Thr Val Arg Thr Lys Lys Gln Glu Leu Ser 
            420                 425                 430         


Glu Ala Glu Gln Ala Thr Arg Thr Met Gln Ala Leu Pro Tyr Ser Thr 
        435                 440                 445             


Val Gly Asn Ser Asn Asn Tyr Leu His Leu Ser Val Leu Arg Thr Glu 
    450                 455                 460                 


Leu Arg Pro Gly Glu Thr Leu Asn Val Asn Phe Leu Leu Arg Met Asp 
465                 470                 475                 480 


Arg Ala His Glu Ala Lys Ile Arg Tyr Tyr Thr Tyr Leu Ile Met Asn 
                485                 490                 495     


Lys Gly Arg Leu Leu Lys Ala Gly Arg Gln Val Arg Glu Pro Gly Gln 
            500                 505                 510         


Asp Leu Val Val Leu Pro Leu Ser Ile Thr Thr Asp Phe Ile Pro Ser 
        515                 520                 525             


Phe Arg Leu Val Ala Tyr Tyr Thr Leu Ile Gly Ala Ser Gly Gln Arg 
    530                 535                 540                 


Glu Val Val Ala Asp Ser Val Trp Val Asp Val Lys Asp Ser Cys Val 
545                 550                 555                 560 


Gly Ser Leu Val Val Lys Ser Gly Gln Ser Glu Asp Arg Gln Pro Val 
                565                 570                 575     


Pro Gly Gln Gln Met Thr Leu Lys Ile Glu Gly Asp His Gly Ala Arg 
            580                 585                 590         


Val Val Leu Val Ala Val Asp Lys Gly Val Phe Val Leu Asn Lys Lys 
        595                 600                 605             


Asn Lys Leu Thr Gln Ser Lys Ile Trp Asp Val Val Glu Lys Ala Asp 
    610                 615                 620                 


Ile Gly Cys Thr Pro Gly Ser Gly Lys Asp Tyr Ala Gly Val Phe Ser 
625                 630                 635                 640 


Asp Ala Gly Leu Thr Phe Thr Ser Ser Ser Gly Gln Gln Thr Ala Gln 
                645                 650                 655     


Arg Ala Glu Leu Gln Cys Pro Gln Pro Ala Ala Arg Arg Arg Arg Ser 
            660                 665                 670         


Val Gln Leu Thr Glu Lys Arg Met Asp Lys Val Gly Lys Tyr Pro Lys 
        675                 680                 685             


Glu Leu Arg Lys Cys Cys Glu Asp Gly Met Arg Glu Asn Pro Met Arg 
    690                 695                 700                 


Phe Ser Cys Gln Arg Arg Thr Arg Phe Ile Ser Leu Gly Glu Ala Cys 
705                 710                 715                 720 


Lys Lys Val Phe Leu Asp Cys Cys Asn Tyr Ile Thr Glu Leu Arg Arg 
                725                 730                 735     


Gln His Ala Arg Ala Ser His Leu Gly Leu Ala Arg Ser Asn Leu Asp 
            740                 745                 750         


Glu Asp Ile Ile Ala Glu Glu Asn Ile Val Ser Arg Ser Glu Phe Pro 
        755                 760                 765             


Glu Ser Trp Leu Trp Asn Val Glu Asp Leu Lys Glu Pro Pro Lys Asn 
    770                 775                 780                 


Gly Ile Ser Thr Lys Leu Met Asn Ile Phe Leu Lys Asp Ser Ile Thr 
785                 790                 795                 800 


Thr Trp Glu Ile Leu Ala Val Ser Met Ser Asp Lys Lys Gly Ile Cys 
                805                 810                 815     


Val Ala Asp Pro Phe Glu Val Thr Val Met Gln Asp Phe Phe Ile Asp 
            820                 825                 830         


Leu Arg Leu Pro Tyr Ser Val Val Arg Asn Glu Gln Val Glu Ile Arg 
        835                 840                 845             


Ala Val Leu Tyr Asn Tyr Arg Gln Asn Gln Glu Leu Lys Val Arg Val 
    850                 855                 860                 


Glu Leu Leu His Asn Pro Ala Phe Cys Ser Leu Ala Thr Thr Lys Arg 
865                 870                 875                 880 


Arg His Gln Gln Thr Val Thr Ile Pro Pro Lys Ser Ser Leu Ser Val 
                885                 890                 895     


Pro Tyr Val Ile Val Pro Leu Lys Thr Gly Leu Gln Glu Val Glu Val 
            900                 905                 910         


Lys Ala Ala Val Tyr His His Phe Ile Ser Asp Gly Val Arg Lys Ser 
        915                 920                 925             


Leu Lys Val Val Pro Glu Gly Ile Arg Met Asn Lys Thr Val Ala Val 
    930                 935                 940                 


Arg Thr Leu Asp Pro Glu Arg Leu Gly Arg Glu Gly Val Gln Lys Glu 
945                 950                 955                 960 


Asp Ile Pro Pro Ala Asp Leu Ser Asp Gln Val Pro Asp Thr Glu Ser 
                965                 970                 975     


Glu Thr Arg Ile Leu Leu Gln Gly Thr Pro Val Ala Gln Met Thr Glu 
            980                 985                 990         


Asp Ala Val Asp Ala Glu Arg Leu  Lys His Leu Ile Val  Thr Pro Ser 
        995                 1000                 1005             


Gly Cys  Gly Glu Gln Asn Met  Ile Gly Met Thr Pro  Thr Val Ile 
    1010                 1015                 1020             


Ala Val  His Tyr Leu Asp Glu  Thr Glu Gln Trp Glu  Lys Phe Gly 
    1025                 1030                 1035             


Leu Glu  Lys Arg Gln Gly Ala  Leu Glu Leu Ile Lys  Lys Gly Tyr 
    1040                 1045                 1050             


Thr Gln  Gln Leu Ala Phe Arg  Gln Pro Ser Ser Ala  Phe Ala Ala 
    1055                 1060                 1065             


Phe Val  Lys Arg Ala Pro Ser  Thr Trp Leu Thr Ala  Tyr Val Val 
    1070                 1075                 1080             


Lys Val  Phe Ser Leu Ala Val  Asn Leu Ile Ala Ile  Asp Ser Gln 
    1085                 1090                 1095             


Val Leu  Cys Gly Ala Val Lys  Trp Leu Ile Leu Glu  Lys Gln Lys 
    1100                 1105                 1110             


Pro Asp  Gly Val Phe Gln Glu  Asp Ala Pro Val Ile  His Gln Glu 
    1115                 1120                 1125             


Met Ile  Gly Gly Leu Arg Asn  Asn Asn Glu Lys Asp  Met Ala Leu 
    1130                 1135                 1140             


Thr Ala  Phe Val Leu Ile Ser  Leu Gln Glu Ala Lys  Asp Ile Cys 
    1145                 1150                 1155             


Glu Glu  Gln Val Asn Ser Leu  Pro Gly Ser Ile Thr  Lys Ala Gly 
    1160                 1165                 1170             


Asp Phe  Leu Glu Ala Asn Tyr  Met Asn Leu Gln Arg  Ser Tyr Thr 
    1175                 1180                 1185             


Val Ala  Ile Ala Gly Tyr Ala  Leu Ala Gln Met Gly  Arg Leu Lys 
    1190                 1195                 1200             


Gly Pro  Leu Leu Asn Lys Phe  Leu Thr Thr Ala Lys  Asp Lys Asn 
    1205                 1210                 1215             


Arg Trp  Glu Asp Pro Gly Lys  Gln Leu Tyr Asn Val  Glu Ala Thr 
    1220                 1225                 1230             


Ser Tyr  Ala Leu Leu Ala Leu  Leu Gln Leu Lys Asp  Phe Asp Phe 
    1235                 1240                 1245             


Val Pro  Pro Val Val Arg Trp  Leu Asn Glu Gln Arg  Tyr Tyr Gly 
    1250                 1255                 1260             


Gly Gly  Tyr Gly Ser Thr Gln  Ala Thr Phe Met Val  Phe Gln Ala 
    1265                 1270                 1275             


Leu Ala  Gln Tyr Gln Lys Asp  Ala Pro Asp His Gln  Glu Leu Asn 
    1280                 1285                 1290             


Leu Asp  Val Ser Leu Gln Leu  Pro Ser Arg Ser Ser  Lys Ile Thr 
    1295                 1300                 1305             


His Arg  Ile His Trp Glu Ser  Ala Ser Leu Leu Arg  Ser Glu Glu 
    1310                 1315                 1320             


Thr Lys  Glu Asn Glu Gly Phe  Thr Val Thr Ala Glu  Gly Lys Gly 
    1325                 1330                 1335             


Gln Gly  Thr Leu Ser Val Val  Thr Met Tyr His Ala  Lys Ala Lys 
    1340                 1345                 1350             


Asp Gln  Leu Thr Cys Asn Lys  Phe Asp Leu Lys Val  Thr Ile Lys 
    1355                 1360                 1365             


Pro Ala  Pro Glu Thr Glu Lys  Arg Pro Gln Asp Ala  Lys Asn Thr 
    1370                 1375                 1380             


Met Ile  Leu Glu Ile Cys Thr  Arg Tyr Arg Gly Asp  Gln Asp Ala 
    1385                 1390                 1395             


Thr Met  Ser Ile Leu Asp Ile  Ser Met Met Thr Gly  Phe Ala Pro 
    1400                 1405                 1410             


Asp Thr  Asp Asp Leu Lys Gln  Leu Ala Asn Gly Val  Asp Arg Tyr 
    1415                 1420                 1425             


Ile Ser  Lys Tyr Glu Leu Asp  Lys Ala Phe Ser Asp  Arg Asn Thr 
    1430                 1435                 1440             


Leu Ile  Ile Tyr Leu Asp Lys  Val Ser His Ser Glu  Asp Asp Cys 
    1445                 1450                 1455             


Leu Ala  Phe Lys Val His Gln  Tyr Phe Asn Val Glu  Leu Ile Gln 
    1460                 1465                 1470             


Pro Gly  Ala Val Lys Val Tyr  Ala Tyr Tyr Asn Leu  Glu Glu Ser 
    1475                 1480                 1485             


Cys Thr  Arg Phe Tyr His Pro  Glu Lys Glu Asp Gly  Lys Leu Asn 
    1490                 1495                 1500             


Lys Leu  Cys Arg Asp Glu Leu  Cys Arg Cys Ala Glu  Glu Asn Cys 
    1505                 1510                 1515             


Phe Ile  Gln Lys Ser Asp Asp  Lys Val Thr Leu Glu  Glu Arg Leu 
    1520                 1525                 1530             


Asp Lys  Ala Cys Glu Pro Gly  Val Asp Tyr Val Tyr  Lys Thr Arg 
    1535                 1540                 1545             


Leu Val  Lys Val Gln Leu Ser  Asn Asp Phe Asp Glu  Tyr Ile Met 
    1550                 1555                 1560             


Ala Ile  Glu Gln Thr Ile Lys  Ser Gly Ser Asp Glu  Val Gln Val 
    1565                 1570                 1575             


Gly Gln  Gln Arg Thr Phe Ile  Ser Pro Ile Lys Cys  Arg Glu Ala 
    1580                 1585                 1590             


Leu Lys  Leu Glu Glu Lys Lys  His Tyr Leu Met Trp  Gly Leu Ser 
    1595                 1600                 1605             


Ser Asp  Phe Trp Gly Glu Lys  Pro Asn Leu Ser Tyr  Ile Ile Gly 
    1610                 1615                 1620             


Lys Asp  Thr Trp Val Glu His  Trp Pro Glu Glu Asp  Glu Cys Gln 
    1625                 1630                 1635             


Asp Glu  Glu Asn Gln Lys Gln  Cys Gln Asp Leu Gly  Ala Phe Thr 
    1640                 1645                 1650             


Glu Ser  Met Val Val Phe Gly  Cys Pro Asn 
    1655                 1660             


<210>  1887
<211>  103
<212>  PRT
<213>  Homo Sapiens

<400>  1887

Met Val Leu Glu Ala His Asp Ala Gln Gly Asp Val Pro Val Thr Val 
1               5                   10                  15      


Thr Val His Asp Phe Pro Gly Lys Lys Leu Val Leu Ser Ser Glu Lys 
            20                  25                  30          


Thr Val Leu Thr Pro Ala Thr Asn His Met Gly Asn Val Thr Phe Thr 
        35                  40                  45              


Ile Pro Ala Asn Arg Glu Phe Lys Ser Glu Lys Gly Arg Asn Lys Phe 
    50                  55                  60                  


Val Thr Val Gln Ala Thr Phe Gly Thr Gln Val Val Glu Lys Val Val 
65                  70                  75                  80  


Leu Val Ser Leu Gln Ser Gly Tyr Leu Phe Ile Gln Thr Asp Lys Thr 
                85                  90                  95      


Ile Tyr Thr Pro Gly Ser Thr 
            100             


<210>  1888
<211>  101
<212>  PRT
<213>  Homo Sapiens

<400>  1888

Asn Asn Glu Lys Asp Met Ala Leu Thr Ala Phe Val Leu Ile Ser Leu 
1               5                   10                  15      


Gln Glu Ala Lys Asp Ile Cys Glu Glu Gln Val Asn Ser Leu Pro Gly 
            20                  25                  30          


Ser Ile Thr Lys Ala Gly Asp Phe Leu Glu Ala Asn Tyr Met Asn Leu 
        35                  40                  45              


Gln Arg Ser Tyr Thr Val Ala Ile Ala Gly Tyr Ala Leu Ala Gln Met 
    50                  55                  60                  


Gly Arg Leu Lys Gly Pro Leu Leu Asn Lys Phe Leu Thr Thr Ala Lys 
65                  70                  75                  80  


Asp Glu Glu Asn Gln Lys Gln Cys Gln Asp Leu Gly Ala Phe Thr Glu 
                85                  90                  95      


Ser Met Val Val Phe 
            100     


<210>  1889
<211>  100
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1889

Xaa Phe Ile Gln Lys Ser Asp Asp Lys Val Thr Leu Glu Glu Arg Leu 
1               5                   10                  15      


Asp Lys Ala Cys Glu Pro Gly Val Asp Tyr Val Tyr Lys Thr Arg Leu 
            20                  25                  30          


Val Lys Val Gln Leu Ser Asn Asp Phe Asp Glu Tyr Ile Met Ala Ile 
        35                  40                  45              


Glu Gln Thr Ile Lys Ser Gly Ser Asp Glu Val Gln Val Gly Gln Gln 
    50                  55                  60                  


Arg Thr Phe Ile Ser Pro Ile Lys Cys Arg Glu Ala Leu Lys Leu Glu 
65                  70                  75                  80  


Glu Lys Lys His Tyr Leu Met Trp Gly Leu Ser Ser Asp Phe Trp Gly 
                85                  90                  95      


Glu Lys Pro Lys 
            100 


<210>  1890
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  1890

Met Ala Gly Gln Pro Ala Ala Thr Gly Ser Pro Ser Ala Asp Lys Asp 
1               5                   10                  15      


Gly Met Glu Pro Asn Val Val Ala Arg Ile Ser Gln Trp Ala Asp Asp 
            20                  25                  30          


His Leu Arg Leu Val Arg Gly His Gly Ile Pro Leu Trp Pro Lys Leu 
        35                  40                  45              


Glu Cys Ser Gly Thr Ile Ile Ala His Cys Cys Cys Ser Thr His Phe 
    50                  55                  60                  


Gly Arg Lys Asp Pro Pro Thr Ser Ala Ser Arg Val Ala Gly Thr Thr 
65                  70                  75                  80  


Glu His Gln His Trp Asn Gly His Ser Trp Asn Asn Val Thr Phe Glu 
                85                  90                  95      


Lys His Ser Thr Asp Ile Lys Ile Tyr Lys Leu Phe Gly Tyr Ser Ser 
            100                 105                 110         


Arg Ile Tyr Lys Lys Lys Cys 
        115                 


<210>  1891
<211>  71
<212>  PRT
<213>  Homo Sapiens

<400>  1891

Met Ala Gly Gln Pro Ala Ala Thr Gly Ser Pro Ser Ala Asp Lys Asp 
1               5                   10                  15      


Gly Met Glu Pro Asn Val Val Ala Arg Ile Ser Gln Trp Ala Asp Asp 
            20                  25                  30          


His Leu Arg Leu Val Arg Asn Ile Ser Thr Gly Met Ala Ile Ala Gly 
        35                  40                  45              


Ile Met Leu Leu Leu Arg Ser Ile Arg Leu Lys Ser His Val Val Leu 
    50                  55                  60                  


Cys Trp Leu Ser Trp Leu Glu 
65                  70      


<210>  1892
<211>  294
<212>  PRT
<213>  Homo Sapiens

<400>  1892

Met Ala Gly Gln Pro Ala Ala Thr Gly Ser Pro Ser Ala Asp Lys Asp 
1               5                   10                  15      


Gly Met Glu Pro Asn Val Val Ala Arg Ile Ser Gln Trp Ala Asp Asp 
            20                  25                  30          


His Leu Arg Leu Val Arg Asn Ile Ser Thr Gly Met Ala Ile Ala Gly 
        35                  40                  45              


Ile Met Leu Leu Leu Arg Ser Ile Arg Leu Thr Ser Lys Phe Thr Ser 
    50                  55                  60                  


Ser Ser Asp Ile Pro Val Glu Phe Ile Arg Arg Asn Val Lys Leu Arg 
65                  70                  75                  80  


Gly Arg Leu Arg Arg Ile Thr Glu Asn Gly Leu Glu Ile Glu His Ile 
                85                  90                  95      


Pro Ile Thr Leu Pro Ile Ile Ala Ser Leu Arg Lys Glu Pro Arg Gly 
            100                 105                 110         


Ala Leu Leu Val Lys Leu Ala Gly Val Glu Leu Ala Glu Thr Gly Lys 
        115                 120                 125             


Ala Trp Leu Gln Lys Glu Leu Lys Pro Ser Gln Leu Leu Trp Phe Gln 
    130                 135                 140                 


Leu Leu Gly Lys Glu Asn Ser Ala Leu Phe Cys Tyr Leu Leu Val Ser 
145                 150                 155                 160 


Lys Gly Gly Tyr Phe Ser Val Asn Leu Asn Glu Glu Ile Leu Arg Arg 
                165                 170                 175     


Gly Leu Gly Lys Thr Val Leu Val Lys Gly Leu Lys Tyr Asp Ser Lys 
            180                 185                 190         


Ile Tyr Trp Thr Val His Arg Asn Leu Leu Lys Ala Glu Leu Thr Ala 
        195                 200                 205             


Leu Lys Lys Gly Glu Gly Ile Trp Lys Glu Asp Ser Glu Lys Glu Ser 
    210                 215                 220                 


Tyr Leu Glu Lys Phe Lys Asp Ser Trp Arg Glu Ile Trp Lys Lys Asp 
225                 230                 235                 240 


Ser Phe Leu Lys Thr Thr Gly Ser Asp Phe Ser Leu Lys Lys Glu Ser 
                245                 250                 255     


Tyr Tyr Glu Lys Leu Lys Arg Thr Tyr Glu Ile Trp Lys Asp Asn Met 
            260                 265                 270         


Asn Asn Cys Ser Leu Ile Leu Lys Phe Arg Glu Leu Ile Ser Arg Ile 
        275                 280                 285             


Asn Phe Arg Arg Lys Gly 
    290                 


<210>  1893
<211>  251
<212>  PRT
<213>  Homo Sapiens

<400>  1893

Met Ala Ile Ala Gly Ile Met Leu Leu Leu Arg Ser Ile Arg Leu Thr 
1               5                   10                  15      


Ser Lys Phe Thr Ser Ser Ser Asp Ile Pro Val Glu Phe Ile Arg Arg 
            20                  25                  30          


Asn Val Lys Leu Arg Gly Arg Leu Arg Arg Ile Thr Glu Asn Gly Leu 
        35                  40                  45              


Glu Ile Glu His Ile Pro Ile Thr Leu Pro Ile Ile Ala Ser Leu Arg 
    50                  55                  60                  


Lys Glu Pro Arg Gly Ala Leu Leu Val Lys Leu Ala Gly Val Glu Leu 
65                  70                  75                  80  


Ala Glu Thr Gly Lys Ala Trp Leu Gln Lys Glu Leu Lys Pro Ser Gln 
                85                  90                  95      


Leu Leu Trp Phe Gln Leu Leu Gly Lys Glu Asn Ser Ala Leu Phe Cys 
            100                 105                 110         


Tyr Leu Leu Val Ser Lys Gly Gly Tyr Phe Ser Val Asn Leu Asn Glu 
        115                 120                 125             


Glu Ile Leu Arg Arg Gly Leu Gly Lys Thr Val Leu Val Lys Gly Leu 
    130                 135                 140                 


Lys Tyr Asp Ser Lys Ile Tyr Trp Thr Val His Arg Asn Leu Leu Lys 
145                 150                 155                 160 


Ala Glu Leu Thr Ala Leu Lys Lys Gly Glu Gly Ile Trp Lys Glu Asp 
                165                 170                 175     


Ser Glu Lys Glu Ser Tyr Leu Glu Lys Phe Lys Asp Ser Trp Arg Glu 
            180                 185                 190         


Ile Trp Lys Lys Asp Ser Phe Leu Lys Thr Thr Gly Ser Asp Phe Ser 
        195                 200                 205             


Leu Lys Lys Glu Ser Tyr Tyr Glu Lys Leu Lys Arg Thr Tyr Glu Ile 
    210                 215                 220                 


Trp Lys Asp Asn Met Asn Asn Cys Ser Leu Ile Leu Lys Phe Arg Glu 
225                 230                 235                 240 


Leu Ile Ser Arg Ile Asn Phe Arg Arg Lys Gly 
                245                 250     


<210>  1894
<211>  115
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1894

Xaa Ala Gly Gln Pro Ala Ala Thr Gly Ser Pro Ser Ala Asp Lys Asp 
1               5                   10                  15      


Gly Met Glu Pro Asn Val Val Ala Arg Ile Ser Gln Trp Ala Asp Asp 
            20                  25                  30          


His Leu Arg Leu Val Arg Gly His Gly Ile Pro Leu Trp Pro Lys Leu 
        35                  40                  45              


Glu Cys Ser Gly Thr Ile Ile Ala His Cys Cys Cys Ser Thr His Phe 
    50                  55                  60                  


Gly Arg Lys Asp Pro Pro Thr Ser Ala Ser Arg Val Ala Gly Thr Thr 
65                  70                  75                  80  


Asp Gln Val Leu His Leu Ser Pro Arg Leu Glu Cys Asn Gly Val Ile 
                85                  90                  95      


Ser Ala His Cys Asn Leu Cys Leu Pro Gly Ser Ser Asp Cys Pro Ala 
            100                 105                 110         


Ser Pro Ser 
        115 


<210>  1895
<211>  213
<212>  PRT
<213>  Homo Sapiens

<400>  1895

Met Glu Ser Leu Leu Leu Leu Pro Arg Phe Gly Arg Ile Ser Asp Leu 
1               5                   10                  15      


Thr Val Asp Leu Ser Thr Pro Glu Gly Ser Phe Pro Ser Asp Glu Gly 
            20                  25                  30          


Trp Pro Phe Ala Lys Tyr Leu Gly Ala Cys Gly Arg Met Val Ala Val 
        35                  40                  45              


Asn Tyr Val Gly Glu Glu Leu Trp Ser Tyr Phe Asn Ala Pro Trp Glu 
    50                  55                  60                  


Lys Arg Val Asp Leu Ala Trp Gln Leu Met Glu Ile Ala Glu Gln Leu 
65                  70                  75                  80  


Thr Asn Asn Asp Phe Glu Phe Ala Leu Tyr Leu Leu Asp Val Ser Phe 
                85                  90                  95      


Asp Asn Phe Ala Val Gly Pro Arg Asp Gly Lys Val Ile Ile Val Asp 
            100                 105                 110         


Ala Glu Asn Val Leu Val Ala Asp Lys Arg Leu Ile Arg Gln Asn Lys 
        115                 120                 125             


Pro Glu Asn Trp Asp Val Trp Tyr Glu Ser Lys Phe Asp Asp Cys Asp 
    130                 135                 140                 


Lys Glu Ala Cys Leu Ser Phe Ser Lys Glu Ile Leu Cys Ala Arg Ala 
145                 150                 155                 160 


Thr Val Asp His Asn Tyr Tyr Ala Val Cys Gln Asn Leu Leu Ser Arg 
                165                 170                 175     


His Ala Thr Trp Arg Gly Thr Ser Gly Gly Leu Leu His Asp Pro Pro 
            180                 185                 190         


Ser Glu Ile Ala Lys Asp Gly Arg Leu Glu Ala Leu Leu Asp Glu Cys 
        195                 200                 205             


Ala Asn Pro Lys Lys 
    210             


<210>  1896
<211>  221
<212>  PRT
<213>  Homo Sapiens

<400>  1896

Met Lys Ser Glu Asn Gly Thr Val Val Gly Ser Phe Pro Ser Asp Glu 
1               5                   10                  15      


Gly Trp Pro Phe Ala Lys Tyr Leu Gly Ala Cys Gly Arg Met Val Ala 
            20                  25                  30          


Val Asn Tyr Val Gly Glu Glu Leu Trp Ser Tyr Phe Asn Ala Pro Trp 
        35                  40                  45              


Glu Lys Arg Val Asp Leu Ala Trp Gln Leu Met Glu Ile Ala Glu Gln 
    50                  55                  60                  


Leu Thr Asn Asn Asp Phe Glu Phe Ala Leu Tyr Leu Leu Asp Val Ser 
65                  70                  75                  80  


Phe Asp Asn Phe Ala Val Gly Pro Arg Asp Gly Lys Val Ile Ile Val 
                85                  90                  95      


Asp Ala Glu Asn Val Leu Val Ala Asp Lys Arg Leu Ile Arg Gln Asn 
            100                 105                 110         


Lys Pro Glu Asn Trp Asp Val Trp Tyr Glu Ser Lys Phe Asp Asp Cys 
        115                 120                 125             


Asp Lys Glu Ala Cys Leu Ser Phe Ser Lys Glu Ile Leu Cys Ala Arg 
    130                 135                 140                 


Ala Thr Val Asp His Asn Tyr Tyr Ala Val Cys Gln Asn Leu Leu Ser 
145                 150                 155                 160 


Arg His Ala Thr Trp Arg Gly Thr Ser Gly Gly Leu Leu His Asp Pro 
                165                 170                 175     


Pro Ser Glu Ile Ala Lys Asp Gly Arg Leu Glu Ala Leu Leu Asp Glu 
            180                 185                 190         


Cys Ala Asn Pro Lys Lys Arg Tyr Gly Arg Phe Gln Ala Ala Lys Glu 
        195                 200                 205             


Leu Arg Glu Tyr Leu Ala Gln Leu Ser Asn Asn Val Arg 
    210                 215                 220     


<210>  1897
<211>  192
<212>  PRT
<213>  Homo Sapiens

<400>  1897

Met Val Ala Val Asn Tyr Val Gly Glu Glu Leu Trp Ser Tyr Phe Asn 
1               5                   10                  15      


Ala Pro Trp Glu Lys Arg Val Asp Leu Ala Trp Gln Leu Met Glu Ile 
            20                  25                  30          


Ala Glu Gln Leu Thr Asn Asn Asp Phe Glu Phe Ala Leu Tyr Leu Leu 
        35                  40                  45              


Asp Val Ser Phe Asp Asn Phe Ala Val Gly Pro Arg Asp Gly Lys Val 
    50                  55                  60                  


Ile Ile Val Asp Ala Glu Asn Val Leu Val Ala Asp Lys Arg Leu Ile 
65                  70                  75                  80  


Arg Gln Asn Lys Pro Glu Asn Trp Asp Val Trp Tyr Glu Ser Lys Phe 
                85                  90                  95      


Asp Asp Cys Asp Lys Glu Ala Cys Leu Ser Phe Ser Lys Glu Ile Leu 
            100                 105                 110         


Cys Ala Arg Ala Thr Val Asp His Asn Tyr Tyr Ala Val Cys Gln Asn 
        115                 120                 125             


Leu Leu Ser Arg His Ala Thr Trp Arg Gly Thr Ser Gly Gly Leu Leu 
    130                 135                 140                 


His Asp Pro Pro Ser Glu Ile Ala Lys Asp Gly Arg Leu Glu Ala Leu 
145                 150                 155                 160 


Leu Asp Glu Cys Ala Asn Pro Lys Lys Arg Tyr Gly Arg Phe Gln Ala 
                165                 170                 175     


Ala Lys Glu Leu Arg Glu Tyr Leu Ala Gln Leu Ser Asn Asn Val Arg 
            180                 185                 190         


<210>  1898
<211>  430
<212>  PRT
<213>  Homo Sapiens

<400>  1898

Met Trp Arg Leu Val Pro Pro Lys Leu Gly Arg Leu Ser Arg Ser Leu 
1               5                   10                  15      


Lys Leu Ala Ala Leu Gly Ser Leu Leu Val Leu Met Val Leu His Ser 
            20                  25                  30          


Pro Ser Leu Leu Ala Ser Trp Gln Arg Asn Glu Leu Thr Asp Arg Arg 
        35                  40                  45              


Phe Leu Gln Leu Asn Lys Cys Pro Ala Cys Phe Gly Thr Ser Trp Cys 
    50                  55                  60                  


Arg Arg Phe Leu Asn Gly Gln Val Val Phe Glu Ala Trp Gly Arg Leu 
65                  70                  75                  80  


Arg Leu Leu Asp Phe Leu Asn Val Lys Asn Val Tyr Phe Ala Gln Tyr 
                85                  90                  95      


Gly Glu Pro Arg Glu Gly Gly Arg Arg Arg Val Val Leu Lys Arg Leu 
            100                 105                 110         


Gly Ser Gln Arg Glu Leu Ala Gln Leu Asp Gln Ser Ile Cys Lys Arg 
        115                 120                 125             


Ala Thr Gly Arg Pro Arg Cys Asp Leu Leu Gln Ala Met Pro Arg Thr 
    130                 135                 140                 


Glu Phe Ala Arg Leu Asn Gly Asp Val Arg Leu Leu Thr Pro Glu Ala 
145                 150                 155                 160 


Val Glu Gly Trp Ser Asp Leu Val His Cys Pro Ser Gln Arg Leu Leu 
                165                 170                 175     


Asp Arg Leu Val Arg Arg Tyr Ala Glu Thr Lys Asp Ser Gly Ser Phe 
            180                 185                 190         


Leu Leu Arg Asn Leu Lys Asp Ser Glu Arg Met Gln Leu Leu Leu Thr 
        195                 200                 205             


Leu Ala Phe Asn Pro Glu Pro Leu Val Leu Gln Ser Phe Pro Ser Asp 
    210                 215                 220                 


Glu Gly Trp Pro Phe Ala Lys Tyr Leu Gly Ala Cys Gly Arg Met Val 
225                 230                 235                 240 


Ala Val Asn Tyr Val Gly Glu Glu Leu Trp Ser Tyr Phe Asn Ala Pro 
                245                 250                 255     


Trp Glu Lys Arg Val Asp Leu Ala Trp Gln Leu Met Glu Ile Ala Glu 
            260                 265                 270         


Gln Leu Thr Asn Asn Asp Phe Glu Phe Ala Leu Tyr Leu Leu Asp Val 
        275                 280                 285             


Ser Phe Asp Asn Phe Ala Val Gly Pro Arg Asp Gly Lys Val Ile Ile 
    290                 295                 300                 


Val Asp Ala Glu Asn Val Leu Val Ala Asp Lys Arg Leu Ile Arg Gln 
305                 310                 315                 320 


Asn Lys Pro Glu Asn Trp Asp Val Trp Tyr Glu Ser Lys Phe Asp Asp 
                325                 330                 335     


Cys Asp Lys Glu Ala Cys Leu Ser Phe Ser Lys Glu Ile Leu Cys Ala 
            340                 345                 350         


Arg Ala Thr Val Asp His Asn Tyr Tyr Ala Val Cys Gln Asn Leu Leu 
        355                 360                 365             


Ser Arg His Ala Thr Trp Arg Gly Thr Ser Gly Gly Leu Leu His Asp 
    370                 375                 380                 


Pro Pro Ser Glu Ile Ala Lys Asp Gly Arg Leu Glu Ala Leu Leu Asp 
385                 390                 395                 400 


Glu Cys Ala Asn Pro Lys Lys Arg Tyr Gly Arg Phe Gln Ala Ala Lys 
                405                 410                 415     


Glu Leu Arg Glu Tyr Leu Ala Gln Leu Ser Asn Asn Val Arg 
            420                 425                 430 


<210>  1899
<211>  1744
<212>  PRT
<213>  Homo Sapiens

<400>  1899

Met Arg Leu Leu Trp Gly Leu Ile Trp Ala Ser Ser Phe Phe Thr Leu 
1               5                   10                  15      


Ser Leu Gln Lys Pro Arg Leu Leu Leu Phe Ser Pro Ser Val Val His 
            20                  25                  30          


Leu Gly Val Pro Leu Ser Val Gly Val Gln Leu Gln Asp Val Pro Arg 
        35                  40                  45              


Gly Gln Val Val Lys Gly Ser Val Phe Leu Arg Asn Pro Ser Arg Asn 
    50                  55                  60                  


Asn Val Pro Cys Ser Pro Lys Val Asp Phe Thr Leu Ser Ser Glu Arg 
65                  70                  75                  80  


Asp Phe Ala Leu Leu Ser Leu Gln Val Pro Leu Lys Asp Ala Lys Ser 
                85                  90                  95      


Cys Gly Leu His Gln Leu Leu Arg Gly Pro Glu Val Gln Leu Val Ala 
            100                 105                 110         


His Ser Pro Trp Leu Lys Asp Ser Leu Ser Arg Thr Thr Asn Ile Gln 
        115                 120                 125             


Gly Ile Asn Leu Leu Phe Ser Ser Arg Arg Gly His Leu Phe Leu Gln 
    130                 135                 140                 


Thr Asp Gln Pro Ile Tyr Asn Pro Gly Gln Arg Val Arg Tyr Arg Val 
145                 150                 155                 160 


Phe Ala Leu Asp Gln Lys Met Arg Pro Ser Thr Asp Thr Ile Thr Val 
                165                 170                 175     


Met Val Glu Asn Ser His Gly Leu Arg Val Arg Lys Lys Glu Val Tyr 
            180                 185                 190         


Met Pro Ser Ser Ile Phe Gln Asp Asp Phe Val Ile Pro Asp Ile Ser 
        195                 200                 205             


Glu Pro Gly Thr Trp Lys Ile Ser Ala Arg Phe Ser Asp Gly Leu Glu 
    210                 215                 220                 


Ser Asn Ser Ser Thr Gln Phe Glu Val Lys Lys Tyr Val Leu Pro Asn 
225                 230                 235                 240 


Phe Glu Val Lys Ile Thr Pro Gly Lys Pro Tyr Ile Leu Thr Val Pro 
                245                 250                 255     


Gly His Leu Asp Glu Met Gln Leu Asp Ile Gln Ala Arg Tyr Ile Tyr 
            260                 265                 270         


Gly Lys Pro Val Gln Gly Val Ala Tyr Val Arg Phe Gly Leu Leu Asp 
        275                 280                 285             


Glu Asp Gly Lys Lys Thr Phe Phe Arg Gly Leu Glu Ser Gln Thr Lys 
    290                 295                 300                 


Leu Val Asn Gly Gln Ser His Ile Ser Leu Ser Lys Ala Glu Phe Gln 
305                 310                 315                 320 


Asp Ala Leu Glu Lys Leu Asn Met Gly Ile Thr Asp Leu Gln Gly Leu 
                325                 330                 335     


Arg Leu Tyr Val Ala Ala Ala Ile Ile Glu Ser Pro Gly Gly Glu Met 
            340                 345                 350         


Glu Glu Ala Glu Leu Thr Ser Trp Tyr Phe Val Ser Ser Pro Phe Ser 
        355                 360                 365             


Leu Asp Leu Ser Lys Thr Lys Arg His Leu Val Pro Gly Ala Pro Phe 
    370                 375                 380                 


Leu Leu Gln Ala Leu Val Arg Glu Met Ser Gly Ser Pro Ala Ser Gly 
385                 390                 395                 400 


Ile Pro Val Lys Val Ser Ala Thr Val Ser Ser Pro Gly Ser Val Pro 
                405                 410                 415     


Glu Val Gln Asp Ile Gln Gln Asn Thr Asp Gly Ser Gly Gln Val Ser 
            420                 425                 430         


Ile Pro Ile Ile Ile Pro Gln Thr Ile Ser Glu Leu Gln Leu Ser Val 
        435                 440                 445             


Ser Ala Gly Ser Pro His Pro Ala Ile Ala Arg Leu Thr Val Ala Ala 
    450                 455                 460                 


Pro Pro Ser Gly Gly Pro Gly Phe Leu Ser Ile Glu Arg Pro Asp Ser 
465                 470                 475                 480 


Arg Pro Pro Arg Val Gly Asp Thr Leu Asn Leu Asn Leu Arg Ala Val 
                485                 490                 495     


Gly Ser Gly Ala Thr Phe Ser His Tyr Tyr Tyr Met Ile Leu Ser Arg 
            500                 505                 510         


Gly Gln Ile Val Phe Met Asn Arg Glu Pro Lys Arg Thr Leu Thr Ser 
        515                 520                 525             


Val Ser Val Phe Val Asp His His Leu Ala Pro Ser Phe Tyr Phe Val 
    530                 535                 540                 


Ala Phe Tyr Tyr His Gly Asp His Pro Val Ala Asn Ser Leu Arg Val 
545                 550                 555                 560 


Asp Val Gln Ala Gly Ala Cys Glu Gly Lys Leu Glu Leu Ser Val Asp 
                565                 570                 575     


Gly Ala Lys Gln Tyr Arg Asn Gly Glu Ser Val Lys Leu His Leu Glu 
            580                 585                 590         


Thr Asp Ser Leu Ala Leu Val Ala Leu Gly Ala Leu Asp Thr Ala Leu 
        595                 600                 605             


Tyr Ala Ala Gly Ser Lys Ser His Lys Pro Leu Asn Met Gly Lys Val 
    610                 615                 620                 


Phe Glu Ala Met Asn Ser Tyr Asp Leu Gly Cys Gly Pro Gly Gly Gly 
625                 630                 635                 640 


Asp Ser Ala Leu Gln Val Phe Gln Ala Ala Gly Leu Ala Phe Ser Asp 
                645                 650                 655     


Gly Asp Gln Trp Thr Leu Ser Arg Lys Arg Leu Ser Cys Pro Lys Glu 
            660                 665                 670         


Lys Thr Thr Arg Lys Lys Arg Asn Val Asn Phe Gln Lys Ala Ile Asn 
        675                 680                 685             


Glu Lys Leu Gly Gln Tyr Ala Ser Pro Thr Ala Lys Arg Cys Cys Gln 
    690                 695                 700                 


Asp Gly Val Thr Arg Leu Pro Met Met Arg Ser Cys Glu Gln Arg Ala 
705                 710                 715                 720 


Ala Arg Val Gln Gln Pro Asp Cys Arg Glu Pro Phe Leu Ser Cys Cys 
                725                 730                 735     


Gln Phe Ala Glu Ser Leu Arg Lys Lys Ser Arg Asp Lys Gly Gln Ala 
            740                 745                 750         


Gly Leu Gln Arg Ala Leu Glu Ile Leu Gln Glu Glu Asp Leu Ile Asp 
        755                 760                 765             


Glu Asp Asp Ile Pro Val Arg Ser Phe Phe Pro Glu Asn Trp Leu Trp 
    770                 775                 780                 


Arg Val Glu Thr Val Asp Arg Phe Gln Ile Leu Thr Leu Trp Leu Pro 
785                 790                 795                 800 


Asp Ser Leu Thr Thr Trp Glu Ile His Gly Leu Ser Leu Ser Lys Thr 
                805                 810                 815     


Lys Gly Leu Cys Val Ala Thr Pro Val Gln Leu Arg Val Phe Arg Glu 
            820                 825                 830         


Phe His Leu His Leu Arg Leu Pro Met Ser Val Arg Arg Phe Glu Gln 
        835                 840                 845             


Leu Glu Leu Arg Pro Val Leu Tyr Asn Tyr Leu Asp Lys Asn Leu Thr 
    850                 855                 860                 


Val Ser Val His Val Ser Pro Val Glu Gly Leu Cys Leu Ala Gly Gly 
865                 870                 875                 880 


Gly Gly Leu Ala Gln Gln Val Leu Val Pro Ala Gly Ser Ala Arg Pro 
                885                 890                 895     


Val Ala Phe Ser Val Val Pro Thr Ala Ala Ala Ala Val Ser Leu Lys 
            900                 905                 910         


Val Val Ala Arg Gly Ser Phe Glu Phe Pro Val Gly Asp Ala Val Ser 
        915                 920                 925             


Lys Val Leu Gln Ile Glu Lys Glu Gly Ala Ile His Arg Glu Glu Leu 
    930                 935                 940                 


Val Tyr Glu Leu Asn Pro Leu Asp His Arg Gly Arg Thr Leu Glu Ile 
945                 950                 955                 960 


Pro Gly Asn Ser Asp Pro Asn Met Ile Pro Asp Gly Asp Phe Asn Ser 
                965                 970                 975     


Tyr Val Arg Val Thr Ala Ser Asp Pro Leu Asp Thr Leu Gly Ser Glu 
            980                 985                 990         


Gly Ala Leu Ser Pro Gly Gly Val  Ala Ser Leu Leu Arg  Leu Pro Arg 
        995                 1000                 1005             


Gly Cys  Gly Glu Gln Thr Met  Ile Tyr Leu Ala Pro  Thr Leu Ala 
    1010                 1015                 1020             


Ala Ser  Arg Tyr Leu Asp Lys  Thr Glu Gln Trp Ser  Thr Leu Pro 
    1025                 1030                 1035             


Pro Glu  Thr Lys Asp His Ala  Val Asp Leu Ile Gln  Lys Gly Tyr 
    1040                 1045                 1050             


Met Arg  Ile Gln Gln Phe Arg  Lys Ala Asp Gly Ser  Tyr Ala Ala 
    1055                 1060                 1065             


Trp Leu  Ser Arg Asp Ser Ser  Thr Trp Leu Thr Ala  Phe Val Leu 
    1070                 1075                 1080             


Lys Val  Leu Ser Leu Ala Gln  Glu Gln Val Gly Gly  Ser Pro Glu 
    1085                 1090                 1095             


Lys Leu  Gln Glu Thr Ser Asn  Trp Leu Leu Ser Gln  Gln Gln Ala 
    1100                 1105                 1110             


Asp Gly  Ser Phe Gln Asp Pro  Cys Pro Val Leu Asp  Arg Ser Met 
    1115                 1120                 1125             


Gln Gly  Gly Leu Val Gly Asn  Asp Glu Thr Val Ala  Leu Thr Ala 
    1130                 1135                 1140             


Phe Val  Thr Ile Ala Leu His  His Gly Leu Ala Val  Phe Gln Asp 
    1145                 1150                 1155             


Glu Gly  Ala Glu Pro Leu Lys  Gln Arg Val Glu Ala  Ser Ile Ser 
    1160                 1165                 1170             


Lys Ala  Asn Ser Phe Leu Gly  Glu Lys Ala Ser Ala  Gly Leu Leu 
    1175                 1180                 1185             


Gly Ala  His Ala Ala Ala Ile  Thr Ala Tyr Ala Leu  Thr Leu Thr 
    1190                 1195                 1200             


Lys Ala  Pro Val Asp Leu Leu  Gly Val Ala His Asn  Asn Leu Met 
    1205                 1210                 1215             


Ala Met  Ala Gln Glu Thr Gly  Asp Asn Leu Tyr Trp  Gly Ser Val 
    1220                 1225                 1230             


Thr Gly  Ser Gln Ser Asn Ala  Val Ser Pro Thr Pro  Ala Pro Arg 
    1235                 1240                 1245             


Asn Pro  Ser Asp Pro Met Pro  Gln Ala Pro Ala Leu  Trp Ile Glu 
    1250                 1255                 1260             


Thr Thr  Ala Tyr Ala Leu Leu  His Leu Leu Leu His  Glu Gly Lys 
    1265                 1270                 1275             


Ala Glu  Met Ala Asp Gln Ala  Ser Ala Trp Leu Thr  Arg Gln Gly 
    1280                 1285                 1290             


Ser Phe  Gln Gly Gly Phe Arg  Ser Thr Gln Asp Thr  Val Ile Ala 
    1295                 1300                 1305             


Leu Asp  Ala Leu Ser Ala Tyr  Trp Ile Ala Ser His  Thr Thr Glu 
    1310                 1315                 1320             


Glu Arg  Gly Leu Asn Val Thr  Leu Ser Ser Thr Gly  Arg Asn Gly 
    1325                 1330                 1335             


Phe Lys  Ser His Ala Leu Gln  Leu Asn Asn Arg Gln  Ile Arg Gly 
    1340                 1345                 1350             


Leu Glu  Glu Glu Leu Gln Phe  Ser Leu Gly Ser Lys  Ile Asn Val 
    1355                 1360                 1365             


Lys Val  Gly Gly Asn Ser Lys  Gly Thr Leu Lys Val  Leu Arg Thr 
    1370                 1375                 1380             


Tyr Asn  Val Leu Asp Met Lys  Asn Thr Thr Cys Gln  Asp Leu Gln 
    1385                 1390                 1395             


Ile Glu  Val Thr Val Lys Gly  His Val Glu Tyr Thr  Met Glu Ala 
    1400                 1405                 1410             


Asn Glu  Asp Tyr Glu Asp Tyr  Glu Tyr Asp Glu Leu  Pro Ala Lys 
    1415                 1420                 1425             


Asp Asp  Pro Asp Ala Pro Leu  Gln Pro Val Thr Pro  Leu Gln Leu 
    1430                 1435                 1440             


Phe Glu  Gly Arg Arg Asn Arg  Arg Arg Arg Glu Ala  Pro Lys Val 
    1445                 1450                 1455             


Val Glu  Glu Gln Glu Ser Arg  Val His Tyr Thr Val  Cys Ile Trp 
    1460                 1465                 1470             


Arg Asn  Gly Lys Val Gly Leu  Ser Gly Met Ala Ile  Ala Asp Val 
    1475                 1480                 1485             


Thr Leu  Leu Ser Gly Phe His  Ala Leu Arg Ala Asp  Leu Glu Lys 
    1490                 1495                 1500             


Leu Thr  Ser Leu Ser Asp Arg  Tyr Val Ser His Phe  Glu Thr Glu 
    1505                 1510                 1515             


Gly Pro  His Val Leu Leu Tyr  Phe Asp Ser Val Pro  Thr Ser Arg 
    1520                 1525                 1530             


Glu Cys  Val Gly Phe Glu Ala  Val Gln Glu Val Pro  Val Gly Leu 
    1535                 1540                 1545             


Val Gln  Pro Ala Ser Ala Thr  Leu Tyr Asp Tyr Tyr  Asn Pro Glu 
    1550                 1555                 1560             


Arg Arg  Cys Ser Val Phe Tyr  Gly Ala Pro Ser Lys  Ser Arg Leu 
    1565                 1570                 1575             


Leu Ala  Thr Leu Cys Ser Ala  Glu Val Cys Gln Cys  Ala Glu Gly 
    1580                 1585                 1590             


Lys Cys  Pro Arg Gln Arg Arg  Ala Leu Glu Arg Gly  Leu Gln Asp 
    1595                 1600                 1605             


Glu Asp  Gly Tyr Arg Met Lys  Phe Ala Cys Tyr Tyr  Pro Arg Val 
    1610                 1615                 1620             


Glu Tyr  Gly Phe Gln Val Lys  Val Leu Arg Glu Asp  Ser Arg Ala 
    1625                 1630                 1635             


Ala Phe  Arg Leu Phe Glu Thr  Lys Ile Thr Gln Val  Leu His Phe 
    1640                 1645                 1650             


Thr Lys  Asp Val Lys Ala Ala  Ala Asn Gln Met Arg  Asn Phe Leu 
    1655                 1660                 1665             


Val Arg  Ala Ser Cys Arg Leu  Arg Leu Glu Pro Gly  Lys Glu Tyr 
    1670                 1675                 1680             


Leu Ile  Met Gly Leu Asp Gly  Ala Thr Tyr Asp Leu  Glu Gly His 
    1685                 1690                 1695             


Pro Gln  Tyr Leu Leu Asp Ser  Asn Ser Trp Ile Glu  Glu Met Pro 
    1700                 1705                 1710             


Ser Glu  Arg Leu Cys Arg Ser  Thr Arg Gln Arg Ala  Ala Cys Ala 
    1715                 1720                 1725             


Gln Leu  Asn Asp Phe Leu Gln  Glu Tyr Gly Thr Gln  Gly Cys Gln 
    1730                 1735                 1740             


Val 
    


<210>  1900
<211>  1698
<212>  PRT
<213>  Homo Sapiens

<400>  1900

Met Arg Leu Leu Trp Gly Leu Ile Trp Ala Ser Ser Phe Phe Thr Leu 
1               5                   10                  15      


Ser Leu Gln Lys Pro Arg Leu Leu Leu Phe Ser Pro Ser Val Val His 
            20                  25                  30          


Leu Gly Val Pro Leu Ser Val Gly Val Gln Leu Gln Asp Val Pro Arg 
        35                  40                  45              


Gly Gln Val Val Lys Gly Ser Val Phe Leu Arg Asn Pro Ser Arg Asn 
    50                  55                  60                  


Asn Val Pro Cys Ser Pro Lys Val Asp Phe Thr Leu Ser Ser Glu Arg 
65                  70                  75                  80  


Asp Phe Ala Leu Leu Ser Leu Gln Val Pro Leu Lys Asp Ala Lys Ser 
                85                  90                  95      


Cys Gly Leu His Gln Leu Leu Arg Gly Pro Glu Val Gln Leu Val Ala 
            100                 105                 110         


His Ser Pro Trp Leu Lys Asp Ser Leu Ser Arg Thr Thr Asn Ile Gln 
        115                 120                 125             


Gly Ile Asn Leu Leu Phe Ser Ser Arg Arg Gly His Leu Phe Leu Gln 
    130                 135                 140                 


Thr Asp Gln Pro Ile Tyr Asn Pro Gly Gln Arg Val Arg Tyr Arg Val 
145                 150                 155                 160 


Phe Ala Leu Asp Gln Lys Met Arg Pro Ser Thr Asp Thr Ile Thr Val 
                165                 170                 175     


Met Val Glu Asn Ser His Gly Leu Arg Val Arg Lys Lys Glu Val Tyr 
            180                 185                 190         


Met Pro Ser Ser Ile Phe Gln Asp Asp Phe Val Ile Pro Asp Ile Ser 
        195                 200                 205             


Glu Pro Gly Thr Trp Lys Ile Ser Ala Arg Phe Ser Asp Gly Leu Glu 
    210                 215                 220                 


Ser Asn Ser Ser Thr Gln Phe Glu Val Lys Lys Tyr Val Leu Pro Asn 
225                 230                 235                 240 


Phe Glu Val Lys Ile Thr Pro Gly Lys Pro Tyr Ile Leu Thr Val Pro 
                245                 250                 255     


Gly His Leu Asp Glu Met Gln Leu Asp Ile Gln Ala Arg Tyr Ile Tyr 
            260                 265                 270         


Gly Lys Pro Val Gln Gly Val Ala Tyr Val Arg Phe Gly Leu Leu Asp 
        275                 280                 285             


Glu Asp Gly Lys Lys Thr Phe Phe Arg Gly Leu Glu Ser Gln Thr Lys 
    290                 295                 300                 


Leu Val Asn Gly Gln Ser His Ile Ser Leu Ser Lys Ala Glu Phe Gln 
305                 310                 315                 320 


Asp Ala Leu Glu Lys Leu Asn Met Gly Ile Thr Asp Leu Gln Gly Leu 
                325                 330                 335     


Arg Leu Tyr Val Ala Ala Ala Ile Ile Glu Ser Pro Gly Gly Glu Met 
            340                 345                 350         


Glu Glu Ala Glu Leu Thr Ser Trp Tyr Phe Val Ser Ser Pro Phe Ser 
        355                 360                 365             


Leu Asp Leu Ser Lys Thr Lys Arg His Leu Val Pro Gly Ala Pro Phe 
    370                 375                 380                 


Leu Leu Gln Ala Leu Val Arg Glu Met Ser Gly Ser Pro Ala Ser Gly 
385                 390                 395                 400 


Ile Pro Val Lys Val Ser Ala Thr Val Ser Ser Pro Gly Ser Val Pro 
                405                 410                 415     


Glu Val Gln Asp Ile Gln Gln Asn Thr Asp Gly Ser Gly Gln Val Ser 
            420                 425                 430         


Ile Pro Ile Ile Ile Pro Gln Thr Ile Ser Glu Leu Gln Leu Ser Val 
        435                 440                 445             


Ser Ala Gly Ser Pro His Pro Ala Ile Ala Arg Leu Thr Val Ala Ala 
    450                 455                 460                 


Pro Pro Ser Gly Gly Pro Gly Phe Leu Ser Ile Glu Arg Pro Asp Ser 
465                 470                 475                 480 


Arg Pro Pro Arg Val Gly Asp Thr Leu Asn Leu Asn Leu Arg Ala Val 
                485                 490                 495     


Gly Ser Gly Ala Thr Phe Ser His Tyr Tyr Tyr Met Ile Leu Ser Arg 
            500                 505                 510         


Gly Gln Ile Val Phe Met Asn Arg Glu Pro Lys Arg Thr Leu Thr Ser 
        515                 520                 525             


Val Ser Val Phe Val Asp His His Leu Ala Pro Ser Phe Tyr Phe Val 
    530                 535                 540                 


Ala Phe Tyr Tyr His Gly Asp His Pro Val Ala Asn Ser Leu Arg Val 
545                 550                 555                 560 


Asp Val Gln Ala Gly Ala Cys Glu Gly Lys Leu Glu Leu Ser Val Asp 
                565                 570                 575     


Gly Ala Lys Gln Tyr Arg Asn Gly Glu Ser Val Lys Leu His Leu Glu 
            580                 585                 590         


Thr Asp Ser Leu Ala Leu Val Ala Leu Gly Ala Leu Asp Thr Ala Leu 
        595                 600                 605             


Tyr Ala Ala Gly Ser Lys Ser His Lys Pro Leu Asn Met Gly Lys Val 
    610                 615                 620                 


Phe Glu Ala Met Asn Ser Tyr Asp Leu Gly Cys Gly Pro Gly Gly Gly 
625                 630                 635                 640 


Asp Ser Ala Leu Gln Val Phe Gln Ala Ala Gly Leu Ala Phe Ser Asp 
                645                 650                 655     


Gly Asp Gln Trp Thr Leu Ser Arg Lys Arg Leu Ser Cys Pro Lys Glu 
            660                 665                 670         


Lys Thr Thr Arg Lys Lys Arg Asn Val Asn Phe Gln Lys Ala Ile Asn 
        675                 680                 685             


Glu Lys Leu Gly Gln Tyr Ala Ser Pro Thr Ala Lys Arg Cys Cys Gln 
    690                 695                 700                 


Asp Gly Val Thr Arg Leu Pro Met Met Arg Ser Cys Glu Gln Arg Ala 
705                 710                 715                 720 


Ala Arg Val Gln Gln Pro Asp Cys Arg Glu Pro Phe Leu Ser Cys Cys 
                725                 730                 735     


Gln Phe Ala Glu Ser Leu Arg Lys Lys Ser Arg Asp Lys Gly Gln Ala 
            740                 745                 750         


Gly Leu Gln Arg Ala Leu Glu Ile Leu Gln Glu Glu Asp Leu Ile Asp 
        755                 760                 765             


Glu Asp Asp Ile Pro Val Arg Ser Phe Phe Pro Glu Asn Trp Leu Trp 
    770                 775                 780                 


Arg Val Glu Thr Val Asp Arg Phe Gln Ile Leu Thr Leu Trp Leu Pro 
785                 790                 795                 800 


Asp Ser Leu Thr Thr Trp Glu Ile His Gly Leu Ser Leu Ser Lys Thr 
                805                 810                 815     


Lys Gly Leu Cys Val Ala Thr Pro Val Gln Leu Arg Val Phe Arg Glu 
            820                 825                 830         


Phe His Leu His Leu Arg Leu Pro Met Ser Val Arg Arg Phe Glu Gln 
        835                 840                 845             


Leu Glu Leu Arg Pro Val Leu Tyr Asn Tyr Leu Asp Lys Asn Leu Thr 
    850                 855                 860                 


Val Ser Val His Val Ser Pro Val Glu Gly Leu Cys Leu Ala Gly Gly 
865                 870                 875                 880 


Gly Gly Leu Ala Gln Gln Val Leu Val Pro Ala Gly Ser Ala Arg Pro 
                885                 890                 895     


Val Ala Phe Ser Val Val Pro Thr Ala Ala Ala Ala Val Ser Leu Lys 
            900                 905                 910         


Val Val Ala Arg Gly Ser Phe Glu Phe Pro Val Gly Asp Ala Val Ser 
        915                 920                 925             


Lys Val Leu Gln Ile Glu Lys Glu Gly Ala Ile His Arg Glu Glu Leu 
    930                 935                 940                 


Val Tyr Glu Leu Asn Pro Leu Asp His Arg Gly Arg Thr Leu Glu Ile 
945                 950                 955                 960 


Pro Gly Asn Ser Asp Pro Asn Met Ile Pro Asp Gly Asp Phe Asn Ser 
                965                 970                 975     


Tyr Val Arg Val Thr Ala Ser Asp Pro Leu Asp Thr Leu Gly Ser Glu 
            980                 985                 990         


Gly Ala Leu Ser Pro Gly Gly Val  Ala Ser Leu Leu Arg  Leu Pro Arg 
        995                 1000                 1005             


Gly Cys  Gly Glu Gln Thr Met  Ile Tyr Leu Ala Pro  Thr Leu Ala 
    1010                 1015                 1020             


Ala Ser  Arg Tyr Leu Asp Lys  Thr Glu Gln Trp Ser  Thr Leu Pro 
    1025                 1030                 1035             


Pro Glu  Thr Lys Asp His Ala  Val Asp Leu Ile Gln  Lys Gly Tyr 
    1040                 1045                 1050             


Met Arg  Ile Gln Gln Phe Arg  Lys Ala Asp Gly Ser  Tyr Ala Ala 
    1055                 1060                 1065             


Trp Leu  Ser Arg Asp Ser Ser  Thr Trp Leu Thr Ala  Phe Val Leu 
    1070                 1075                 1080             


Lys Val  Leu Ser Leu Ala Gln  Glu Gln Val Gly Gly  Ser Pro Glu 
    1085                 1090                 1095             


Lys Leu  Gln Glu Thr Ser Asn  Trp Leu Leu Ser Gln  Gln Gln Ala 
    1100                 1105                 1110             


Asp Gly  Ser Phe Gln Asp Pro  Cys Pro Val Leu Asp  Arg Ser Met 
    1115                 1120                 1125             


Gln Gly  Gly Leu Val Gly Asn  Asp Glu Thr Val Ala  Leu Thr Ala 
    1130                 1135                 1140             


Phe Val  Thr Ile Ala Leu His  His Gly Leu Ala Val  Phe Gln Asp 
    1145                 1150                 1155             


Glu Gly  Ala Glu Pro Leu Lys  Gln Arg Val Glu Ala  Ser Ile Ser 
    1160                 1165                 1170             


Lys Ala  Asn Ser Phe Leu Gly  Glu Lys Ala Ser Ala  Gly Leu Leu 
    1175                 1180                 1185             


Gly Ala  His Ala Ala Ala Ile  Thr Ala Tyr Ala Leu  Thr Leu Thr 
    1190                 1195                 1200             


Lys Ala  Pro Val Asp Leu Leu  Gly Val Ala His Asn  Asn Leu Met 
    1205                 1210                 1215             


Ala Met  Ala Gln Glu Thr Gly  Asp Asn Leu Tyr Trp  Gly Ser Val 
    1220                 1225                 1230             


Thr Gly  Ser Gln Ser Asn Ala  Val Ser Pro Thr Pro  Ala Pro Arg 
    1235                 1240                 1245             


Asn Pro  Ser Asp Pro Met Pro  Gln Ala Pro Ala Leu  Trp Ile Glu 
    1250                 1255                 1260             


Thr Thr  Ala Tyr Ala Leu Leu  His Leu Leu Leu His  Glu Gly Lys 
    1265                 1270                 1275             


Ala Glu  Met Ala Asp Gln Ala  Ser Ala Trp Leu Thr  Arg Gln Gly 
    1280                 1285                 1290             


Ser Phe  Gln Gly Gly Phe Arg  Ser Thr Gln Asp Thr  Val Ile Ala 
    1295                 1300                 1305             


Leu Asp  Ala Leu Ser Ala Tyr  Trp Ile Ala Ser His  Thr Thr Glu 
    1310                 1315                 1320             


Glu Arg  Gly Leu Asn Val Thr  Leu Ser Ser Thr Gly  Arg Asn Gly 
    1325                 1330                 1335             


Phe Lys  Ser His Ala Leu Gln  Leu Asn Asn Arg Gln  Ile Arg Gly 
    1340                 1345                 1350             


Leu Glu  Glu Glu Leu Gln Phe  Ser Leu Gly Ser Lys  Ile Asn Val 
    1355                 1360                 1365             


Lys Val  Gly Gly Asn Ser Lys  Gly Thr Leu Lys Val  Leu Arg Thr 
    1370                 1375                 1380             


Tyr Asn  Val Leu Asp Met Lys  Asn Thr Thr Cys Gln  Asp Leu Gln 
    1385                 1390                 1395             


Ile Glu  Val Thr Val Lys Gly  His Val Glu Tyr Thr  Met Glu Ala 
    1400                 1405                 1410             


Asn Glu  Asp Tyr Glu Asp Tyr  Glu Tyr Asp Glu Leu  Pro Ala Lys 
    1415                 1420                 1425             


Asp Asp  Pro Asp Ala Pro Leu  Gln Pro Val Thr Pro  Leu Gln Leu 
    1430                 1435                 1440             


Phe Glu  Gly Arg Arg Asn Arg  Arg Arg Arg Glu Ala  Pro Lys Leu 
    1445                 1450                 1455             


Thr Ser  Leu Ser Asp Arg Tyr  Val Ser His Phe Glu  Thr Glu Gly 
    1460                 1465                 1470             


Pro His  Val Leu Leu Tyr Phe  Asp Ser Val Pro Thr  Ser Arg Glu 
    1475                 1480                 1485             


Cys Val  Gly Phe Glu Ala Val  Gln Glu Val Pro Val  Gly Leu Val 
    1490                 1495                 1500             


Gln Pro  Ala Ser Ala Thr Leu  Tyr Asp Tyr Tyr Asn  Pro Glu Arg 
    1505                 1510                 1515             


Arg Cys  Ser Val Phe Tyr Gly  Ala Pro Ser Lys Ser  Arg Leu Leu 
    1520                 1525                 1530             


Ala Thr  Leu Cys Ser Ala Glu  Val Cys Gln Cys Ala  Glu Gly Lys 
    1535                 1540                 1545             


Cys Pro  Arg Gln Arg Arg Ala  Leu Glu Arg Gly Leu  Gln Asp Glu 
    1550                 1555                 1560             


Asp Gly  Tyr Arg Met Lys Phe  Ala Cys Tyr Tyr Pro  Arg Val Glu 
    1565                 1570                 1575             


Tyr Gly  Phe Gln Val Lys Val  Leu Arg Glu Asp Ser  Arg Ala Ala 
    1580                 1585                 1590             


Phe Arg  Leu Phe Glu Thr Lys  Ile Thr Gln Val Leu  His Phe Thr 
    1595                 1600                 1605             


Lys Asp  Val Lys Ala Ala Ala  Asn Gln Met Arg Asn  Phe Leu Val 
    1610                 1615                 1620             


Arg Ala  Ser Cys Arg Leu Arg  Leu Glu Pro Gly Lys  Glu Tyr Leu 
    1625                 1630                 1635             


Ile Met  Gly Leu Asp Gly Ala  Thr Tyr Asp Leu Glu  Gly His Pro 
    1640                 1645                 1650             


Gln Tyr  Leu Leu Asp Ser Asn  Ser Trp Ile Glu Glu  Met Pro Ser 
    1655                 1660                 1665             


Glu Arg  Leu Cys Arg Ser Thr  Arg Gln Arg Ala Ala  Cys Ala Gln 
    1670                 1675                 1680             


Leu Asn  Asp Phe Leu Gln Glu  Tyr Gly Thr Gln Gly  Cys Gln Val 
    1685                 1690                 1695             


<210>  1901
<211>  1698
<212>  PRT
<213>  Homo Sapiens

<400>  1901

Met Arg Leu Leu Trp Gly Leu Ile Trp Ala Ser Ser Phe Phe Thr Leu 
1               5                   10                  15      


Ser Leu Gln Lys Pro Arg Leu Leu Leu Phe Ser Pro Ser Val Val His 
            20                  25                  30          


Leu Gly Val Pro Leu Ser Val Gly Val Gln Leu Gln Asp Val Pro Arg 
        35                  40                  45              


Gly Gln Val Val Lys Gly Ser Val Phe Leu Arg Asn Pro Ser Arg Asn 
    50                  55                  60                  


Asn Val Pro Cys Ser Pro Lys Val Asp Phe Thr Leu Ser Ser Glu Arg 
65                  70                  75                  80  


Asp Phe Ala Leu Leu Ser Leu Gln Val Pro Leu Lys Asp Ala Lys Ser 
                85                  90                  95      


Cys Gly Leu His Gln Leu Leu Arg Gly Pro Glu Val Gln Leu Val Ala 
            100                 105                 110         


His Ser Pro Trp Leu Lys Asp Ser Leu Ser Arg Thr Thr Asn Ile Gln 
        115                 120                 125             


Gly Ile Asn Leu Leu Phe Ser Ser Arg Arg Gly His Leu Phe Leu Gln 
    130                 135                 140                 


Thr Asp Gln Pro Ile Tyr Asn Pro Gly Gln Arg Val Arg Tyr Arg Val 
145                 150                 155                 160 


Phe Ala Leu Asp Gln Lys Met Arg Pro Ser Thr Asp Thr Ile Thr Val 
                165                 170                 175     


Met Val Glu Asn Ser His Gly Leu Arg Val Arg Lys Lys Glu Val Tyr 
            180                 185                 190         


Met Pro Ser Ser Ile Phe Gln Asp Asp Phe Val Ile Pro Asp Ile Ser 
        195                 200                 205             


Glu Pro Gly Thr Trp Lys Ile Ser Ala Arg Phe Ser Asp Gly Leu Glu 
    210                 215                 220                 


Ser Asn Ser Ser Thr Gln Phe Glu Val Lys Lys Tyr Val Leu Pro Asn 
225                 230                 235                 240 


Phe Glu Val Lys Ile Thr Pro Gly Lys Pro Tyr Ile Leu Thr Val Pro 
                245                 250                 255     


Gly His Leu Asp Glu Met Gln Leu Asp Ile Gln Ala Arg Tyr Ile Tyr 
            260                 265                 270         


Gly Lys Pro Val Gln Gly Val Ala Tyr Val Arg Phe Gly Leu Leu Asp 
        275                 280                 285             


Glu Asp Gly Lys Lys Thr Phe Phe Arg Gly Leu Glu Ser Gln Thr Lys 
    290                 295                 300                 


Leu Val Asn Gly Gln Ser His Ile Ser Leu Ser Lys Ala Glu Phe Gln 
305                 310                 315                 320 


Asp Ala Leu Glu Lys Leu Asn Met Gly Ile Thr Asp Leu Gln Gly Leu 
                325                 330                 335     


Arg Leu Tyr Val Ala Ala Ala Ile Ile Glu Ser Pro Gly Gly Glu Met 
            340                 345                 350         


Glu Glu Ala Glu Leu Thr Ser Trp Tyr Phe Val Ser Ser Pro Phe Ser 
        355                 360                 365             


Leu Asp Leu Ser Lys Thr Lys Arg His Leu Val Pro Gly Ala Pro Phe 
    370                 375                 380                 


Leu Leu Gln Ala Leu Val Arg Glu Met Ser Gly Ser Pro Ala Ser Gly 
385                 390                 395                 400 


Ile Pro Val Lys Val Ser Ala Thr Val Ser Ser Pro Gly Ser Val Pro 
                405                 410                 415     


Glu Val Gln Asp Ile Gln Gln Asn Thr Asp Gly Ser Gly Gln Val Ser 
            420                 425                 430         


Ile Pro Ile Ile Ile Pro Gln Thr Ile Ser Glu Leu Gln Leu Ser Val 
        435                 440                 445             


Ser Ala Gly Ser Pro His Pro Ala Ile Ala Arg Leu Thr Val Ala Ala 
    450                 455                 460                 


Pro Pro Ser Gly Gly Pro Gly Phe Leu Ser Ile Glu Arg Pro Asp Ser 
465                 470                 475                 480 


Arg Pro Pro Arg Val Gly Asp Thr Leu Asn Leu Asn Leu Arg Ala Val 
                485                 490                 495     


Gly Ser Gly Ala Thr Phe Ser His Tyr Tyr Tyr Met Ile Leu Ser Arg 
            500                 505                 510         


Gly Gln Ile Val Phe Met Asn Arg Glu Pro Lys Arg Thr Leu Thr Ser 
        515                 520                 525             


Val Ser Val Phe Val Asp His His Leu Ala Pro Ser Phe Tyr Phe Val 
    530                 535                 540                 


Ala Phe Tyr Tyr His Gly Asp His Pro Val Ala Asn Ser Leu Arg Val 
545                 550                 555                 560 


Asp Val Gln Ala Gly Ala Cys Glu Gly Lys Leu Glu Leu Ser Val Asp 
                565                 570                 575     


Gly Ala Lys Gln Tyr Arg Asn Gly Glu Ser Val Lys Leu His Leu Glu 
            580                 585                 590         


Thr Asp Ser Leu Ala Leu Val Ala Leu Gly Ala Leu Asp Thr Ala Leu 
        595                 600                 605             


Tyr Ala Ala Gly Ser Lys Ser His Lys Pro Leu Asn Met Gly Lys Val 
    610                 615                 620                 


Phe Glu Ala Met Asn Ser Tyr Asp Leu Gly Cys Gly Pro Gly Gly Gly 
625                 630                 635                 640 


Asp Ser Ala Leu Gln Val Phe Gln Ala Ala Gly Leu Ala Phe Ser Asp 
                645                 650                 655     


Gly Asp Gln Trp Thr Leu Ser Arg Lys Arg Leu Ser Cys Pro Lys Glu 
            660                 665                 670         


Lys Thr Thr Arg Lys Lys Arg Asn Val Asn Phe Gln Lys Ala Ile Asn 
        675                 680                 685             


Glu Lys Leu Gly Gln Tyr Ala Ser Pro Thr Ala Lys Arg Cys Cys Gln 
    690                 695                 700                 


Asp Gly Val Thr Arg Leu Pro Met Met Arg Ser Cys Glu Gln Arg Ala 
705                 710                 715                 720 


Ala Arg Val Gln Gln Pro Asp Cys Arg Glu Pro Phe Leu Ser Cys Cys 
                725                 730                 735     


Gln Phe Ala Glu Ser Leu Arg Lys Lys Ser Arg Asp Lys Gly Gln Ala 
            740                 745                 750         


Gly Leu Gln Arg Ala Leu Glu Ile Leu Gln Glu Glu Asp Leu Ile Asp 
        755                 760                 765             


Glu Asp Asp Ile Pro Val Arg Ser Phe Phe Pro Glu Asn Trp Leu Trp 
    770                 775                 780                 


Arg Val Glu Thr Val Asp Arg Phe Gln Ile Leu Thr Leu Trp Leu Pro 
785                 790                 795                 800 


Asp Ser Leu Thr Thr Trp Glu Ile His Gly Leu Ser Leu Ser Lys Thr 
                805                 810                 815     


Lys Gly Leu Cys Val Ala Thr Pro Val Gln Leu Arg Val Phe Arg Glu 
            820                 825                 830         


Phe His Leu His Leu Arg Leu Pro Met Ser Val Arg Arg Phe Glu Gln 
        835                 840                 845             


Leu Glu Leu Arg Pro Val Leu Tyr Asn Tyr Leu Asp Lys Asn Leu Thr 
    850                 855                 860                 


Val Ser Val His Val Ser Pro Val Glu Gly Leu Cys Leu Ala Gly Gly 
865                 870                 875                 880 


Gly Gly Leu Ala Gln Gln Val Leu Val Pro Ala Gly Ser Ala Arg Pro 
                885                 890                 895     


Val Ala Phe Ser Val Val Pro Thr Ala Ala Thr Ala Val Ser Leu Lys 
            900                 905                 910         


Val Val Ala Arg Gly Ser Phe Glu Phe Pro Val Gly Asp Ala Val Ser 
        915                 920                 925             


Lys Val Leu Gln Ile Glu Lys Glu Gly Ala Ile His Arg Glu Glu Leu 
    930                 935                 940                 


Val Tyr Glu Leu Asn Pro Leu Asp His Arg Gly Arg Thr Leu Glu Ile 
945                 950                 955                 960 


Pro Gly Asn Ser Asp Pro Asn Met Ile Pro Asp Gly Asp Phe Asn Ser 
                965                 970                 975     


Tyr Val Arg Val Thr Ala Ser Asp Pro Leu Asp Thr Leu Gly Ser Glu 
            980                 985                 990         


Gly Ala Leu Ser Pro Gly Gly Val  Ala Ser Leu Leu Arg  Leu Pro Arg 
        995                 1000                 1005             


Gly Cys  Gly Glu Gln Thr Met  Ile Tyr Leu Ala Pro  Thr Leu Ala 
    1010                 1015                 1020             


Ala Ser  Arg Tyr Leu Asp Lys  Thr Glu Gln Trp Ser  Thr Leu Pro 
    1025                 1030                 1035             


Pro Glu  Thr Lys Asp His Ala  Val Asp Leu Ile Gln  Lys Gly Tyr 
    1040                 1045                 1050             


Met Arg  Ile Gln Gln Phe Arg  Lys Ala Asp Gly Ser  Tyr Ala Ala 
    1055                 1060                 1065             


Trp Leu  Ser Arg Gly Ser Ser  Thr Trp Leu Thr Ala  Phe Val Leu 
    1070                 1075                 1080             


Lys Val  Leu Ser Leu Ala Gln  Glu Gln Val Gly Gly  Ser Pro Glu 
    1085                 1090                 1095             


Lys Leu  Gln Glu Thr Ser Asn  Trp Leu Leu Ser Gln  Gln Gln Ala 
    1100                 1105                 1110             


Asp Gly  Ser Phe Gln Asp Leu  Ser Pro Val Ile His  Arg Ser Met 
    1115                 1120                 1125             


Gln Gly  Gly Leu Val Gly Asn  Asp Glu Thr Val Ala  Leu Thr Ala 
    1130                 1135                 1140             


Phe Val  Thr Ile Ala Leu His  His Gly Leu Ala Val  Phe Gln Asp 
    1145                 1150                 1155             


Glu Gly  Ala Glu Pro Leu Lys  Gln Arg Val Glu Ala  Ser Ile Ser 
    1160                 1165                 1170             


Lys Ala  Ser Ser Phe Leu Gly  Glu Lys Ala Ser Ala  Gly Leu Leu 
    1175                 1180                 1185             


Gly Ala  His Ala Ala Ala Ile  Thr Ala Tyr Ala Leu  Thr Leu Thr 
    1190                 1195                 1200             


Lys Ala  Pro Ala Asp Leu Arg  Gly Val Ala His Asn  Asn Leu Met 
    1205                 1210                 1215             


Ala Met  Ala Gln Glu Thr Gly  Asp Asn Leu Tyr Trp  Gly Ser Val 
    1220                 1225                 1230             


Thr Gly  Ser Gln Ser Asn Ala  Val Ser Pro Thr Pro  Ala Pro Arg 
    1235                 1240                 1245             


Asn Pro  Ser Asp Pro Met Pro  Gln Ala Pro Ala Leu  Trp Ile Glu 
    1250                 1255                 1260             


Thr Thr  Ala Tyr Ala Leu Leu  His Leu Leu Leu His  Glu Gly Lys 
    1265                 1270                 1275             


Ala Glu  Met Ala Asp Gln Ala  Ala Ala Trp Leu Thr  Arg Gln Gly 
    1280                 1285                 1290             


Ser Phe  Gln Gly Gly Phe Arg  Ser Thr Gln Asp Thr  Val Ile Ala 
    1295                 1300                 1305             


Leu Asp  Ala Leu Ser Ala Tyr  Trp Ile Ala Ser His  Thr Thr Glu 
    1310                 1315                 1320             


Glu Arg  Gly Leu Asn Val Thr  Leu Ser Ser Thr Gly  Arg Asn Gly 
    1325                 1330                 1335             


Phe Lys  Ser His Ala Leu Gln  Leu Asn Asn Arg Gln  Ile Arg Gly 
    1340                 1345                 1350             


Leu Glu  Glu Glu Leu Gln Phe  Ser Leu Gly Ser Lys  Ile Asn Val 
    1355                 1360                 1365             


Lys Val  Gly Gly Asn Ser Lys  Gly Thr Leu Lys Val  Leu Arg Thr 
    1370                 1375                 1380             


Tyr Asn  Val Leu Asp Met Lys  Asn Thr Thr Cys Gln  Asp Leu Gln 
    1385                 1390                 1395             


Ile Glu  Val Thr Val Lys Gly  His Val Glu Tyr Thr  Met Glu Ala 
    1400                 1405                 1410             


Asn Glu  Asp Tyr Glu Asp Tyr  Glu Tyr Asp Glu Leu  Pro Ala Lys 
    1415                 1420                 1425             


Asp Asp  Pro Asp Ala Pro Leu  Gln Pro Val Thr Pro  Leu Gln Leu 
    1430                 1435                 1440             


Phe Glu  Gly Arg Arg Asn Arg  Arg Arg Arg Glu Ala  Pro Lys Leu 
    1445                 1450                 1455             


Thr Ser  Leu Ser Asp Arg Tyr  Val Ser His Phe Glu  Thr Glu Gly 
    1460                 1465                 1470             


Pro His  Val Leu Leu Tyr Phe  Asp Ser Val Pro Thr  Ser Arg Glu 
    1475                 1480                 1485             


Cys Val  Gly Phe Glu Ala Val  Gln Glu Val Pro Val  Gly Leu Val 
    1490                 1495                 1500             


Gln Pro  Ala Ser Ala Thr Leu  Tyr Asp Tyr Tyr Asn  Pro Glu Arg 
    1505                 1510                 1515             


Arg Cys  Ser Val Phe Tyr Gly  Ala Pro Ser Lys Ser  Arg Leu Leu 
    1520                 1525                 1530             


Ala Thr  Leu Cys Ser Ala Glu  Val Cys Gln Cys Ala  Glu Gly Lys 
    1535                 1540                 1545             


Cys Pro  Arg Gln Arg Arg Ala  Leu Glu Arg Gly Leu  Gln Asp Glu 
    1550                 1555                 1560             


Asp Gly  Tyr Arg Met Lys Phe  Ala Cys Tyr Tyr Pro  Arg Val Glu 
    1565                 1570                 1575             


Tyr Gly  Phe Gln Val Lys Val  Leu Arg Glu Asp Ser  Arg Ala Ala 
    1580                 1585                 1590             


Phe Arg  Leu Phe Glu Thr Lys  Ile Thr Gln Val Leu  His Phe Thr 
    1595                 1600                 1605             


Lys Asp  Val Lys Ala Ala Ala  Asn Gln Met Arg Asn  Phe Leu Val 
    1610                 1615                 1620             


Arg Ala  Ser Cys Arg Leu Arg  Leu Glu Pro Gly Lys  Glu Tyr Leu 
    1625                 1630                 1635             


Ile Met  Gly Leu Asp Gly Ala  Thr Tyr Asp Leu Glu  Gly His Pro 
    1640                 1645                 1650             


Gln Tyr  Leu Leu Asp Ser Asn  Ser Trp Ile Glu Glu  Met Pro Ser 
    1655                 1660                 1665             


Glu Arg  Leu Cys Arg Ser Thr  Arg Gln Arg Ala Ala  Cys Ala Gln 
    1670                 1675                 1680             


Leu Asn  Asp Phe Leu Gln Glu  Tyr Gly Thr Gln Gly  Cys Gln Val 
    1685                 1690                 1695             


<210>  1902
<211>  1744
<212>  PRT
<213>  Homo Sapiens

<400>  1902

Met Arg Leu Leu Trp Gly Leu Ile Trp Ala Ser Ser Phe Phe Thr Leu 
1               5                   10                  15      


Ser Leu Gln Lys Pro Arg Leu Leu Leu Phe Ser Pro Ser Val Val His 
            20                  25                  30          


Leu Gly Val Pro Leu Ser Val Gly Val Gln Leu Gln Asp Val Pro Arg 
        35                  40                  45              


Gly Gln Val Val Lys Gly Ser Val Phe Leu Arg Asn Pro Ser Arg Asn 
    50                  55                  60                  


Asn Val Pro Cys Ser Pro Lys Val Asp Phe Thr Leu Ser Ser Glu Arg 
65                  70                  75                  80  


Asp Phe Ala Leu Leu Ser Leu Gln Val Pro Leu Lys Asp Ala Lys Ser 
                85                  90                  95      


Cys Gly Leu His Gln Leu Leu Arg Gly Pro Glu Val Gln Leu Val Ala 
            100                 105                 110         


His Ser Pro Trp Leu Lys Asp Ser Leu Ser Arg Thr Thr Asn Ile Gln 
        115                 120                 125             


Gly Ile Asn Leu Leu Phe Ser Ser Arg Arg Gly His Leu Phe Leu Gln 
    130                 135                 140                 


Thr Asp Gln Pro Ile Tyr Asn Pro Gly Gln Arg Val Arg Tyr Arg Val 
145                 150                 155                 160 


Phe Ala Leu Asp Gln Lys Met Arg Pro Ser Thr Asp Thr Ile Thr Val 
                165                 170                 175     


Met Val Glu Asn Ser His Gly Leu Arg Val Arg Lys Lys Glu Val Tyr 
            180                 185                 190         


Met Pro Ser Ser Ile Phe Gln Asp Asp Phe Val Ile Pro Asp Ile Ser 
        195                 200                 205             


Glu Pro Gly Thr Trp Lys Ile Ser Ala Arg Phe Ser Asp Gly Leu Glu 
    210                 215                 220                 


Ser Asn Ser Ser Thr Gln Phe Glu Val Lys Lys Tyr Val Leu Pro Asn 
225                 230                 235                 240 


Phe Glu Val Lys Ile Thr Pro Gly Lys Pro Tyr Ile Leu Thr Val Pro 
                245                 250                 255     


Gly His Leu Asp Glu Met Gln Leu Asp Ile Gln Ala Arg Tyr Ile Tyr 
            260                 265                 270         


Gly Lys Pro Val Gln Gly Val Ala Tyr Val Arg Phe Gly Leu Leu Asp 
        275                 280                 285             


Glu Asp Gly Lys Lys Thr Phe Phe Arg Gly Leu Glu Ser Gln Thr Lys 
    290                 295                 300                 


Leu Val Asn Gly Gln Ser His Ile Ser Leu Ser Lys Ala Glu Phe Gln 
305                 310                 315                 320 


Asp Ala Leu Glu Lys Leu Asn Met Gly Ile Thr Asp Leu Gln Gly Leu 
                325                 330                 335     


Arg Leu Tyr Val Ala Ala Ala Ile Ile Glu Ser Pro Gly Gly Glu Met 
            340                 345                 350         


Glu Glu Ala Glu Leu Thr Ser Trp Tyr Phe Val Ser Ser Pro Phe Ser 
        355                 360                 365             


Leu Asp Leu Ser Lys Thr Lys Arg His Leu Val Pro Gly Ala Pro Phe 
    370                 375                 380                 


Leu Leu Gln Ala Leu Val Arg Glu Met Ser Gly Ser Pro Ala Ser Gly 
385                 390                 395                 400 


Ile Pro Val Lys Val Ser Ala Thr Val Ser Ser Pro Gly Ser Val Pro 
                405                 410                 415     


Glu Val Gln Asp Ile Gln Gln Asn Thr Asp Gly Ser Gly Gln Val Ser 
            420                 425                 430         


Ile Pro Ile Ile Ile Pro Gln Thr Ile Ser Glu Leu Gln Leu Ser Val 
        435                 440                 445             


Ser Ala Gly Ser Pro His Pro Ala Ile Ala Arg Leu Thr Val Ala Ala 
    450                 455                 460                 


Pro Pro Ser Gly Gly Pro Gly Phe Leu Ser Ile Glu Arg Pro Asp Ser 
465                 470                 475                 480 


Arg Pro Pro Arg Val Gly Asp Thr Leu Asn Leu Asn Leu Arg Ala Val 
                485                 490                 495     


Gly Ser Gly Ala Thr Phe Ser His Tyr Tyr Tyr Met Ile Leu Ser Arg 
            500                 505                 510         


Gly Gln Ile Val Phe Met Asn Arg Glu Pro Lys Arg Thr Leu Thr Ser 
        515                 520                 525             


Val Ser Val Phe Val Asp His His Leu Ala Pro Ser Phe Tyr Phe Val 
    530                 535                 540                 


Ala Phe Tyr Tyr His Gly Asp His Pro Val Ala Asn Ser Leu Arg Val 
545                 550                 555                 560 


Asp Val Gln Ala Gly Ala Cys Glu Gly Lys Leu Glu Leu Ser Val Asp 
                565                 570                 575     


Gly Ala Lys Gln Tyr Arg Asn Gly Glu Ser Val Lys Leu His Leu Glu 
            580                 585                 590         


Thr Asp Ser Leu Ala Leu Val Ala Leu Gly Ala Leu Asp Thr Ala Leu 
        595                 600                 605             


Tyr Ala Ala Gly Ser Lys Ser His Lys Pro Leu Asn Met Gly Lys Val 
    610                 615                 620                 


Phe Glu Ala Met Asn Ser Tyr Asp Leu Gly Cys Gly Pro Gly Gly Gly 
625                 630                 635                 640 


Asp Ser Ala Leu Gln Val Phe Gln Ala Ala Gly Leu Ala Phe Ser Asp 
                645                 650                 655     


Gly Asp Gln Trp Thr Leu Ser Arg Lys Arg Leu Ser Cys Pro Lys Glu 
            660                 665                 670         


Lys Thr Thr Arg Lys Lys Arg Asn Val Asn Phe Gln Lys Ala Ile Asn 
        675                 680                 685             


Glu Lys Leu Gly Gln Tyr Ala Ser Pro Thr Ala Lys Arg Cys Cys Gln 
    690                 695                 700                 


Asp Gly Val Thr Arg Leu Pro Met Met Arg Ser Cys Glu Gln Arg Ala 
705                 710                 715                 720 


Ala Arg Val Gln Gln Pro Asp Cys Arg Glu Pro Phe Leu Ser Cys Cys 
                725                 730                 735     


Gln Phe Ala Glu Ser Leu Arg Lys Lys Ser Arg Asp Lys Gly Gln Ala 
            740                 745                 750         


Gly Leu Gln Arg Ala Leu Glu Ile Leu Gln Glu Glu Asp Leu Ile Asp 
        755                 760                 765             


Glu Asp Asp Ile Pro Val Arg Ser Phe Phe Pro Glu Asn Trp Leu Trp 
    770                 775                 780                 


Arg Val Glu Thr Val Asp Arg Phe Gln Ile Leu Thr Leu Trp Leu Pro 
785                 790                 795                 800 


Asp Ser Leu Thr Thr Trp Glu Ile His Gly Leu Ser Leu Ser Lys Thr 
                805                 810                 815     


Lys Gly Leu Cys Val Ala Thr Pro Val Gln Leu Arg Val Phe Arg Glu 
            820                 825                 830         


Phe His Leu His Leu Arg Leu Pro Met Ser Val Arg Arg Phe Glu Gln 
        835                 840                 845             


Leu Glu Leu Arg Pro Val Leu Tyr Asn Tyr Leu Asp Lys Asn Leu Thr 
    850                 855                 860                 


Val Ser Val His Val Ser Pro Val Glu Gly Leu Cys Leu Ala Gly Gly 
865                 870                 875                 880 


Gly Gly Leu Ala Gln Gln Val Leu Val Pro Ala Gly Ser Ala Arg Pro 
                885                 890                 895     


Val Ala Phe Ser Val Val Pro Thr Ala Ala Thr Ala Val Ser Leu Lys 
            900                 905                 910         


Val Val Ala Arg Gly Ser Phe Glu Phe Pro Val Gly Asp Ala Val Ser 
        915                 920                 925             


Lys Val Leu Gln Ile Glu Lys Glu Gly Ala Ile His Arg Glu Glu Leu 
    930                 935                 940                 


Val Tyr Glu Leu Asn Pro Leu Asp His Arg Gly Arg Thr Leu Glu Ile 
945                 950                 955                 960 


Pro Gly Asn Ser Asp Pro Asn Met Ile Pro Asp Gly Asp Phe Asn Ser 
                965                 970                 975     


Tyr Val Arg Val Thr Ala Ser Asp Pro Leu Asp Thr Leu Gly Ser Glu 
            980                 985                 990         


Gly Ala Leu Ser Pro Gly Gly Val  Ala Ser Leu Leu Arg  Leu Pro Arg 
        995                 1000                 1005             


Gly Cys  Gly Glu Gln Thr Met  Ile Tyr Leu Ala Pro  Thr Leu Ala 
    1010                 1015                 1020             


Ala Ser  Arg Tyr Leu Asp Lys  Thr Glu Gln Trp Ser  Thr Leu Pro 
    1025                 1030                 1035             


Pro Glu  Thr Lys Asp His Ala  Val Asp Leu Ile Gln  Lys Gly Tyr 
    1040                 1045                 1050             


Met Arg  Ile Gln Gln Phe Arg  Lys Ala Asp Gly Ser  Tyr Ala Ala 
    1055                 1060                 1065             


Trp Leu  Ser Arg Gly Ser Ser  Thr Trp Leu Thr Ala  Phe Val Leu 
    1070                 1075                 1080             


Lys Val  Leu Ser Leu Ala Gln  Glu Gln Val Gly Gly  Ser Pro Glu 
    1085                 1090                 1095             


Lys Leu  Gln Glu Thr Ser Asn  Trp Leu Leu Ser Gln  Gln Gln Ala 
    1100                 1105                 1110             


Asp Gly  Ser Phe Gln Asp Leu  Ser Pro Val Ile His  Arg Ser Met 
    1115                 1120                 1125             


Gln Gly  Gly Leu Val Gly Asn  Asp Glu Thr Val Ala  Leu Thr Ala 
    1130                 1135                 1140             


Phe Val  Thr Ile Ala Leu His  His Gly Leu Ala Val  Phe Gln Asp 
    1145                 1150                 1155             


Glu Gly  Ala Glu Pro Leu Lys  Gln Arg Val Glu Ala  Ser Ile Ser 
    1160                 1165                 1170             


Lys Ala  Ser Ser Phe Leu Gly  Glu Lys Ala Ser Ala  Gly Leu Leu 
    1175                 1180                 1185             


Gly Ala  His Ala Ala Ala Ile  Thr Ala Tyr Ala Leu  Thr Leu Thr 
    1190                 1195                 1200             


Lys Ala  Pro Ala Asp Leu Arg  Gly Val Ala His Asn  Asn Leu Met 
    1205                 1210                 1215             


Ala Met  Ala Gln Glu Thr Gly  Asp Asn Leu Tyr Trp  Gly Ser Val 
    1220                 1225                 1230             


Thr Gly  Ser Gln Ser Asn Ala  Val Ser Pro Thr Pro  Ala Pro Arg 
    1235                 1240                 1245             


Asn Pro  Ser Asp Pro Met Pro  Gln Ala Pro Ala Leu  Trp Ile Glu 
    1250                 1255                 1260             


Thr Thr  Ala Tyr Ala Leu Leu  His Leu Leu Leu His  Glu Gly Lys 
    1265                 1270                 1275             


Ala Glu  Met Ala Asp Gln Ala  Ala Ala Trp Leu Thr  Arg Gln Gly 
    1280                 1285                 1290             


Ser Phe  Gln Gly Gly Phe Arg  Ser Thr Gln Asp Thr  Val Ile Ala 
    1295                 1300                 1305             


Leu Asp  Ala Leu Ser Ala Tyr  Trp Ile Ala Ser His  Thr Thr Glu 
    1310                 1315                 1320             


Glu Arg  Gly Leu Asn Val Thr  Leu Ser Ser Thr Gly  Arg Asn Gly 
    1325                 1330                 1335             


Phe Lys  Ser His Ala Leu Gln  Leu Asn Asn Arg Gln  Ile Arg Gly 
    1340                 1345                 1350             


Leu Glu  Glu Glu Leu Gln Phe  Ser Leu Gly Ser Lys  Ile Asn Val 
    1355                 1360                 1365             


Lys Val  Gly Gly Asn Ser Lys  Gly Thr Leu Lys Val  Leu Arg Thr 
    1370                 1375                 1380             


Tyr Asn  Val Leu Asp Met Lys  Asn Thr Thr Cys Gln  Asp Leu Gln 
    1385                 1390                 1395             


Ile Glu  Val Thr Val Lys Gly  His Val Glu Tyr Thr  Met Glu Ala 
    1400                 1405                 1410             


Asn Glu  Asp Tyr Glu Asp Tyr  Glu Tyr Asp Glu Leu  Pro Ala Lys 
    1415                 1420                 1425             


Asp Asp  Pro Asp Ala Pro Leu  Gln Pro Val Thr Pro  Leu Gln Leu 
    1430                 1435                 1440             


Phe Glu  Gly Arg Arg Asn Arg  Arg Arg Arg Glu Ala  Pro Lys Val 
    1445                 1450                 1455             


Val Glu  Glu Gln Glu Ser Arg  Val His Tyr Thr Val  Cys Ile Trp 
    1460                 1465                 1470             


Arg Asn  Gly Lys Val Gly Leu  Ser Gly Met Ala Ile  Ala Asp Val 
    1475                 1480                 1485             


Thr Leu  Leu Ser Gly Phe His  Ala Leu Arg Ala Asp  Leu Glu Lys 
    1490                 1495                 1500             


Leu Thr  Ser Leu Ser Asp Arg  Tyr Val Ser His Phe  Glu Thr Glu 
    1505                 1510                 1515             


Gly Pro  His Val Leu Leu Tyr  Phe Asp Ser Val Pro  Thr Ser Arg 
    1520                 1525                 1530             


Glu Cys  Val Gly Phe Glu Ala  Val Gln Glu Val Pro  Val Gly Leu 
    1535                 1540                 1545             


Val Gln  Pro Ala Ser Ala Thr  Leu Tyr Asp Tyr Tyr  Asn Pro Glu 
    1550                 1555                 1560             


Arg Arg  Cys Ser Val Phe Tyr  Gly Ala Pro Ser Lys  Ser Arg Leu 
    1565                 1570                 1575             


Leu Ala  Thr Leu Cys Ser Ala  Glu Val Cys Gln Cys  Ala Glu Gly 
    1580                 1585                 1590             


Lys Cys  Pro Arg Gln Arg Arg  Ala Leu Glu Arg Gly  Leu Gln Asp 
    1595                 1600                 1605             


Glu Asp  Gly Tyr Arg Met Lys  Phe Ala Cys Tyr Tyr  Pro Arg Val 
    1610                 1615                 1620             


Glu Tyr  Gly Phe Gln Val Lys  Val Leu Arg Glu Asp  Ser Arg Ala 
    1625                 1630                 1635             


Ala Phe  Arg Leu Phe Glu Thr  Lys Ile Thr Gln Val  Leu His Phe 
    1640                 1645                 1650             


Thr Lys  Asp Val Lys Ala Ala  Ala Asn Gln Met Arg  Asn Phe Leu 
    1655                 1660                 1665             


Val Arg  Ala Ser Cys Arg Leu  Arg Leu Glu Pro Gly  Lys Glu Tyr 
    1670                 1675                 1680             


Leu Ile  Met Gly Leu Asp Gly  Ala Thr Tyr Asp Leu  Glu Gly His 
    1685                 1690                 1695             


Pro Gln  Tyr Leu Leu Asp Ser  Asn Ser Trp Ile Glu  Glu Met Pro 
    1700                 1705                 1710             


Ser Glu  Arg Leu Cys Arg Ser  Thr Arg Gln Arg Ala  Ala Cys Ala 
    1715                 1720                 1725             


Gln Leu  Asn Asp Phe Leu Gln  Glu Tyr Gly Thr Gln  Gly Cys Gln 
    1730                 1735                 1740             


Val 
    


<210>  1903
<211>  118
<212>  PRT
<213>  Homo Sapiens

<400>  1903

Met His Pro Pro Lys Thr Pro Ser Gly Ala Leu His Arg Lys Arg Lys 
1               5                   10                  15      


Met Ala Ala Trp Pro Phe Ser Arg Leu Trp Lys Val Ser Asp Pro Ile 
            20                  25                  30          


Leu Phe Gln Met Thr Leu Ile Ala Ala Leu Leu Pro Ala Val Leu Gly 
        35                  40                  45              


Asn Cys Gly Pro Pro Pro Thr Leu Ser Phe Ala Ala Pro Met Asp Ile 
    50                  55                  60                  


Thr Leu Thr Glu Thr Arg Phe Lys Thr Gly Thr Thr Leu Lys Tyr Thr 
65                  70                  75                  80  


Cys Leu Pro Gly Tyr Val Arg Ser His Ser Thr Gln Thr Leu Thr Cys 
                85                  90                  95      


Asn Ser Asp Gly Glu Trp Val Tyr Asn Thr Phe Cys Ile Leu Asp Thr 
            100                 105                 110         


Gly Phe His His Ile Gly 
        115             


<210>  1904
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  1904

Met His Pro Pro Lys Thr Pro Ser Gly Ala Leu His Arg Lys Arg Lys 
1               5                   10                  15      


Met Ala Ala Trp Pro Phe Ser Arg Leu Trp Lys Val Ser Asp Pro Ile 
            20                  25                  30          


Leu Phe Gln Met Thr Leu Ile Ala Ala Leu Leu Pro Ala Val Leu Gly 
        35                  40                  45              


Asn Cys Gly Pro Pro Pro Thr Leu Ser Phe Ala Ala Pro Met Asp Ile 
    50                  55                  60                  


Thr Leu Thr Glu Thr Arg Phe Lys Thr Gly Thr Thr Leu Lys Tyr Thr 
65                  70                  75                  80  


Cys Leu Pro Gly Tyr Val Arg Ser His Ser Thr Gln Thr Leu Thr Cys 
                85                  90                  95      


Asn Ser Asp Gly Glu Trp Val Tyr Asn Thr Phe Cys Ile Tyr Lys Arg 
            100                 105                 110         


Cys Arg His Pro Gly Glu Leu Arg Asn Gly Gln Val Glu Ile Lys Thr 
        115                 120                 125             


Asp Leu Ser Phe Gly Ser Gln Ile Glu Phe Ser Cys Ser Glu Gly Phe 
    130                 135                 140                 


Phe Leu Ile Gly Ser Thr Thr Ser 
145                 150         


<210>  1905
<211>  597
<212>  PRT
<213>  Homo Sapiens

<400>  1905

Met His Pro Pro Lys Thr Pro Ser Gly Ala Leu His Arg Lys Arg Lys 
1               5                   10                  15      


Met Ala Ala Trp Pro Phe Ser Arg Leu Trp Lys Val Ser Asp Pro Ile 
            20                  25                  30          


Leu Phe Gln Met Thr Leu Ile Ala Ala Leu Leu Pro Ala Val Leu Gly 
        35                  40                  45              


Asn Cys Gly Pro Pro Pro Thr Leu Ser Phe Ala Ala Pro Met Asp Ile 
    50                  55                  60                  


Thr Leu Thr Glu Thr Arg Phe Lys Thr Gly Thr Thr Leu Lys Tyr Thr 
65                  70                  75                  80  


Cys Leu Pro Gly Tyr Val Arg Ser His Ser Thr Gln Thr Leu Thr Cys 
                85                  90                  95      


Asn Ser Asp Gly Glu Trp Val Tyr Asn Thr Phe Cys Ile Tyr Lys Arg 
            100                 105                 110         


Cys Arg His Pro Gly Glu Leu Arg Asn Gly Gln Val Glu Ile Lys Thr 
        115                 120                 125             


Asp Leu Ser Phe Gly Ser Gln Ile Glu Phe Ser Cys Ser Glu Gly Phe 
    130                 135                 140                 


Phe Leu Ile Gly Ser Thr Thr Ser Arg Cys Glu Val Gln Asp Arg Gly 
145                 150                 155                 160 


Val Gly Trp Ser His Pro Leu Pro Gln Cys Glu Ile Val Lys Cys Lys 
                165                 170                 175     


Pro Pro Pro Asp Ile Arg Asn Gly Arg His Ser Gly Glu Glu Asn Phe 
            180                 185                 190         


Tyr Ala Tyr Gly Phe Ser Val Thr Tyr Ser Cys Asp Pro Arg Phe Ser 
        195                 200                 205             


Leu Leu Gly His Ala Ser Ile Ser Cys Thr Val Glu Asn Glu Thr Ile 
    210                 215                 220                 


Gly Val Trp Arg Pro Ser Pro Pro Thr Cys Glu Lys Ile Thr Cys Arg 
225                 230                 235                 240 


Lys Pro Asp Val Ser His Gly Glu Met Val Ser Gly Phe Gly Pro Ile 
                245                 250                 255     


Tyr Asn Tyr Lys Asp Thr Ile Val Phe Lys Cys Gln Lys Gly Phe Val 
            260                 265                 270         


Leu Arg Gly Ser Ser Val Ile His Cys Asp Ala Asp Ser Lys Trp Asn 
        275                 280                 285             


Pro Ser Pro Pro Ala Cys Glu Pro Asn Ser Cys Ile Asn Leu Pro Asp 
    290                 295                 300                 


Ile Pro His Ala Ser Trp Glu Thr Tyr Pro Arg Pro Thr Lys Glu Asp 
305                 310                 315                 320 


Val Tyr Val Val Gly Thr Val Leu Arg Tyr Arg Cys His Pro Gly Tyr 
                325                 330                 335     


Lys Pro Thr Thr Asp Glu Pro Thr Thr Val Ile Cys Gln Lys Asn Leu 
            340                 345                 350         


Arg Trp Thr Pro Tyr Gln Gly Cys Glu Ala Leu Cys Cys Pro Glu Pro 
        355                 360                 365             


Lys Leu Asn Asn Gly Glu Ile Thr Gln His Arg Lys Ser Arg Pro Ala 
    370                 375                 380                 


Asn His Cys Val Tyr Phe Tyr Gly Asp Glu Ile Ser Phe Ser Cys His 
385                 390                 395                 400 


Glu Thr Ser Arg Phe Ser Ala Ile Cys Gln Gly Asp Gly Thr Trp Ser 
                405                 410                 415     


Pro Arg Thr Pro Ser Cys Gly Asp Ile Cys Asn Phe Pro Pro Lys Ile 
            420                 425                 430         


Ala His Gly His Tyr Lys Gln Ser Ser Ser Tyr Ser Phe Phe Lys Glu 
        435                 440                 445             


Glu Ile Ile Tyr Glu Cys Asp Lys Gly Tyr Ile Leu Val Gly Gln Ala 
    450                 455                 460                 


Lys Leu Ser Cys Ser Tyr Ser His Trp Ser Ala Pro Ala Pro Gln Cys 
465                 470                 475                 480 


Lys Ala Leu Cys Arg Lys Pro Glu Leu Val Asn Gly Arg Leu Ser Val 
                485                 490                 495     


Asp Lys Asp Gln Tyr Val Glu Pro Glu Asn Val Thr Ile Gln Cys Asp 
            500                 505                 510         


Ser Gly Tyr Gly Val Val Gly Pro Gln Ser Ile Thr Cys Ser Gly Asn 
        515                 520                 525             


Arg Thr Trp Tyr Pro Glu Val Pro Lys Cys Glu Trp Glu Thr Pro Glu 
    530                 535                 540                 


Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met Gln Cys Leu Pro 
545                 550                 555                 560 


Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr Lys Leu Ser Leu 
                565                 570                 575     


Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala Arg Gln Ser Thr 
            580                 585                 590         


Leu Asp Lys Glu Leu 
        595         


<210>  1906
<211>  181
<212>  PRT
<213>  Homo Sapiens

<400>  1906

Met Phe Phe Trp Cys Ala Cys Cys Leu Met Val Ala Trp Arg Val Ser 
1               5                   10                  15      


Ala Ser Asp Ala Glu His Cys Pro Glu Leu Pro Pro Val Asp Asn Ser 
            20                  25                  30          


Ile Phe Val Ala Lys Glu Val Glu Gly Gln Ile Leu Gly Thr Tyr Val 
        35                  40                  45              


Cys Ile Lys Gly Tyr His Leu Val Gly Lys Lys Thr Leu Phe Cys Asn 
    50                  55                  60                  


Ala Ser Lys Glu Trp Asp Asn Thr Thr Thr Glu Cys Arg Leu Gly His 
65                  70                  75                  80  


Cys Pro Asp Pro Val Leu Val Asn Gly Glu Phe Ser Ser Ser Gly Pro 
                85                  90                  95      


Val Asn Val Ser Asp Lys Ile Thr Phe Met Cys Asn Asp His Tyr Ile 
            100                 105                 110         


Leu Lys Gly Ser Asn Arg Ser Gln Cys Leu Glu Asp His Thr Trp Ala 
        115                 120                 125             


Pro Pro Phe Pro Ile Cys Lys Ser Arg Asp Cys Asp Pro Pro Gly Asn 
    130                 135                 140                 


Pro Val His Gly Tyr Phe Glu Gly Asn Asn Phe Thr Leu Gly Ser Thr 
145                 150                 155                 160 


Ile Ser Tyr Tyr Cys Glu Asp Arg Tyr Tyr Leu Val Gly Val Gln Glu 
                165                 170                 175     


Gln Gln Cys Val Asp 
            180     


<210>  1907
<211>  252
<212>  PRT
<213>  Homo Sapiens

<400>  1907

Met Phe Phe Trp Cys Ala Cys Cys Leu Met Val Ala Trp Arg Val Ser 
1               5                   10                  15      


Ala Ser Asp Ala Glu His Cys Pro Glu Leu Pro Pro Val Asp Asn Ser 
            20                  25                  30          


Ile Phe Val Ala Lys Glu Val Glu Gly Gln Ile Leu Gly Thr Tyr Val 
        35                  40                  45              


Cys Ile Lys Gly Tyr His Leu Val Gly Lys Lys Thr Leu Phe Cys Asn 
    50                  55                  60                  


Ala Ser Lys Glu Trp Asp Asn Thr Thr Thr Glu Cys Arg Leu Gly His 
65                  70                  75                  80  


Cys Pro Asp Pro Val Leu Val Asn Gly Glu Phe Ser Ser Ser Gly Pro 
                85                  90                  95      


Val Asn Val Ser Asp Lys Ile Thr Phe Met Cys Asn Asp His Tyr Ile 
            100                 105                 110         


Leu Lys Gly Ser Asn Arg Ser Gln Cys Leu Glu Asp His Thr Trp Ala 
        115                 120                 125             


Pro Pro Phe Pro Ile Cys Lys Ser Arg Asp Cys Asp Pro Pro Gly Asn 
    130                 135                 140                 


Pro Val His Gly Tyr Phe Glu Gly Asn Asn Phe Thr Leu Gly Ser Thr 
145                 150                 155                 160 


Ile Ser Tyr Tyr Cys Glu Asp Arg Tyr Tyr Leu Val Gly Val Gln Glu 
                165                 170                 175     


Gln Gln Cys Val Asp Gly Glu Trp Ser Ser Ala Leu Pro Val Cys Lys 
            180                 185                 190         


Leu Ile Gln Glu Ala Pro Lys Pro Glu Cys Glu Lys Ala Leu Leu Ala 
        195                 200                 205             


Phe Gln Glu Ser Lys Asn Leu Cys Glu Ala Met Glu Asn Phe Met Gln 
    210                 215                 220                 


Gln Leu Lys Glu Ser Gly Met Thr Met Glu Glu Leu Lys Tyr Ser Leu 
225                 230                 235                 240 


Glu Leu Lys Lys Ala Glu Leu Lys Ala Lys Leu Leu 
                245                 250         


<210>  1908
<211>  252
<212>  PRT
<213>  Homo Sapiens

<400>  1908

Met Phe Phe Trp Cys Ala Cys Cys Leu Met Val Ala Trp Arg Val Ser 
1               5                   10                  15      


Ala Ser Asp Ala Glu His Cys Pro Glu Leu Pro Pro Val Asp Asn Ser 
            20                  25                  30          


Ile Phe Val Ala Lys Glu Val Glu Gly Gln Ile Leu Gly Thr Tyr Val 
        35                  40                  45              


Cys Ile Lys Gly Tyr His Leu Val Gly Lys Lys Thr Leu Phe Cys Asn 
    50                  55                  60                  


Ala Ser Lys Glu Trp Asp Asn Thr Thr Thr Glu Cys Arg Leu Gly His 
65                  70                  75                  80  


Cys Pro Asp Pro Val Leu Val Asn Gly Glu Phe Ser Ser Ser Gly Pro 
                85                  90                  95      


Val Asn Val Ser Asp Lys Ile Thr Phe Met Cys Asn Asp His Tyr Ile 
            100                 105                 110         


Leu Lys Gly Ser Asn Arg Ser Gln Cys Leu Glu Asp His Thr Trp Ala 
        115                 120                 125             


Pro Pro Phe Pro Ile Cys Lys Ser Arg Asp Cys Asp Pro Pro Gly Asn 
    130                 135                 140                 


Pro Val His Gly Tyr Phe Glu Gly Asn Asn Phe Thr Leu Gly Ser Thr 
145                 150                 155                 160 


Ile Ser Tyr Tyr Cys Glu Asp Arg Tyr Tyr Leu Val Gly Val Gln Glu 
                165                 170                 175     


Gln Gln Cys Val Asp Gly Glu Trp Ser Ser Ala Leu Pro Val Cys Lys 
            180                 185                 190         


Leu Ile Gln Glu Ala Pro Lys Pro Glu Cys Glu Lys Ala Leu Leu Ala 
        195                 200                 205             


Phe Gln Glu Ser Lys Asn Leu Cys Glu Ala Met Glu Asn Phe Met Gln 
    210                 215                 220                 


Gln Leu Lys Glu Ser Gly Met Thr Met Glu Glu Leu Lys Tyr Ser Leu 
225                 230                 235                 240 


Glu Leu Lys Lys Ala Glu Leu Lys Ala Lys Leu Leu 
                245                 250         


<210>  1909
<211>  252
<212>  PRT
<213>  Homo Sapiens

<400>  1909

Met Phe Phe Trp Cys Ala Cys Cys Leu Met Val Ala Trp Arg Val Ser 
1               5                   10                  15      


Ala Ser Asp Ala Glu His Cys Pro Glu Leu Pro Pro Val Asp Asn Ser 
            20                  25                  30          


Ile Phe Val Ala Lys Glu Val Glu Gly Gln Ile Leu Gly Thr Tyr Val 
        35                  40                  45              


Cys Ile Lys Gly Tyr His Leu Val Gly Lys Lys Thr Leu Phe Cys Asn 
    50                  55                  60                  


Ala Ser Lys Glu Trp Asp Asn Thr Thr Thr Glu Cys Arg Leu Gly His 
65                  70                  75                  80  


Cys Pro Asp Pro Val Leu Val Asn Gly Glu Phe Ser Ser Ser Gly Pro 
                85                  90                  95      


Val Asn Val Ser Asp Lys Ile Thr Phe Met Cys Asn Asp His Tyr Ile 
            100                 105                 110         


Leu Lys Gly Ser Asn Arg Ser Gln Cys Leu Glu Asp His Thr Trp Ala 
        115                 120                 125             


Pro Pro Phe Pro Ile Cys Lys Ser Arg Asp Cys Asp Pro Pro Gly Asn 
    130                 135                 140                 


Pro Val His Gly Tyr Phe Glu Gly Asn Asn Phe Thr Leu Gly Ser Thr 
145                 150                 155                 160 


Ile Ser Tyr Tyr Cys Glu Asp Arg Tyr Tyr Leu Val Gly Val Gln Glu 
                165                 170                 175     


Gln Gln Cys Val Asp Gly Glu Trp Ser Ser Ala Leu Pro Val Cys Lys 
            180                 185                 190         


Leu Ile Gln Glu Ala Pro Lys Pro Glu Cys Glu Lys Ala Leu Leu Ala 
        195                 200                 205             


Phe Gln Glu Ser Lys Asn Leu Cys Glu Ala Met Glu Asn Phe Met Gln 
    210                 215                 220                 


Gln Leu Lys Glu Ser Gly Met Thr Met Glu Glu Leu Lys Tyr Ser Leu 
225                 230                 235                 240 


Glu Leu Lys Lys Ala Glu Leu Lys Ala Lys Leu Leu 
                245                 250         


<210>  1910
<211>  251
<212>  PRT
<213>  Homo Sapiens

<400>  1910

Met Phe Phe Trp Cys Ala Cys Cys Leu Met Val Ala Trp Arg Val Ser 
1               5                   10                  15      


Ala Ser Asp Glu His Cys Pro Glu Leu Pro Pro Val Asp Asn Ser Ile 
            20                  25                  30          


Phe Val Ala Lys Glu Val Glu Gly Gln Ile Leu Gly Thr Tyr Val Cys 
        35                  40                  45              


Ile Lys Gly Tyr His Leu Val Gly Lys Lys Thr Leu Phe Cys Asn Ala 
    50                  55                  60                  


Ser Lys Glu Trp Asp Asn Thr Thr Thr Glu Cys Arg Leu Gly His Cys 
65                  70                  75                  80  


Pro Asp Pro Val Leu Val Asn Gly Glu Phe Ser Ser Ser Gly Pro Val 
                85                  90                  95      


Asn Val Ser Asp Lys Ile Thr Phe Met Cys Asn Asp His Tyr Ile Leu 
            100                 105                 110         


Lys Gly Ser Asn Arg Ser Gln Cys Leu Glu Asp His Thr Trp Ala Pro 
        115                 120                 125             


Pro Phe Pro Ile Cys Lys Ser Arg Asp Cys Asp Pro Pro Gly Asn Pro 
    130                 135                 140                 


Val His Gly Tyr Phe Glu Gly Asn Asn Phe Thr Leu Gly Ser Thr Ile 
145                 150                 155                 160 


Ser Tyr Tyr Cys Glu Asp Arg Tyr Tyr Leu Val Gly Val Gln Glu Gln 
                165                 170                 175     


Gln Cys Val Asp Gly Glu Trp Ser Ser Ala Leu Pro Val Cys Lys Leu 
            180                 185                 190         


Ile Gln Glu Ala Pro Lys Pro Glu Cys Glu Lys Ala Leu Leu Ala Phe 
        195                 200                 205             


Gln Glu Ser Lys Asn Leu Cys Glu Ala Met Glu Asn Phe Met Gln Gln 
    210                 215                 220                 


Leu Lys Glu Ser Gly Met Thr Met Glu Glu Leu Lys Tyr Ser Leu Glu 
225                 230                 235                 240 


Leu Lys Lys Ala Glu Leu Lys Ala Lys Leu Leu 
                245                 250     


<210>  1911
<211>  95
<212>  PRT
<213>  Homo Sapiens

<400>  1911

Met Ala Pro Pro Pro Ala Cys Arg Ser Pro Met Ser Pro Pro Pro Pro 
1               5                   10                  15      


Pro Leu Leu Leu Leu Leu Leu Ser Leu Ala Leu Leu Gly Ala Arg Ala 
            20                  25                  30          


Arg Ala Glu Pro Ala Gly Ser Ala Val Pro Ala Gln Ser Arg Pro Cys 
        35                  40                  45              


Val Asp Cys His Ala Phe Glu Phe Met Gln Arg Ala Leu Gln Asp Leu 
    50                  55                  60                  


Arg Lys Thr Ala Cys Ser Leu Asp Ala Arg Thr Glu Thr Leu Leu Leu 
65                  70                  75                  80  


Gln Ala Glu Arg Arg Ala Leu Cys Ala Cys Trp Pro Ala Gly His 
                85                  90                  95  


<210>  1912
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  1912

Met Arg Val Ala Arg Arg Thr Arg Asn Val Cys Arg Cys Pro Arg Ala 
1               5                   10                  15      


Ala Gly Pro Gly Val Pro Glu Pro Arg Ala Ala Pro Leu Pro Leu Leu 
            20                  25                  30          


Ala Met Ala Pro Pro Pro Ala Cys Arg Ser Pro Met Ser Pro Pro Pro 
        35                  40                  45              


Pro Pro Leu Leu Leu Leu Leu Leu Ser Leu Ala Leu Leu Gly Ala Arg 
    50                  55                  60                  


Ala Arg Ala Glu Pro Ala Gly Ser Ala Val Pro Ala Gln Ser Arg Pro 
65                  70                  75                  80  


Cys Val Asp Cys His Ala Phe Glu Phe Met Gln Arg Ala Leu Gln Asp 
                85                  90                  95      


Leu Arg Lys Thr Ala Cys Ser Leu Asp Ala Arg Thr Glu Thr Leu Leu 
            100                 105                 110         


Leu Gln Ala Glu Arg Arg Ala Leu Cys Ala Cys Trp Pro Ala Gly His 
        115                 120                 125             


<210>  1913
<211>  1676
<212>  PRT
<213>  Homo Sapiens

<400>  1913

Met Gly Leu Leu Gly Ile Leu Cys Phe Leu Ile Phe Leu Gly Lys Thr 
1               5                   10                  15      


Trp Gly Gln Glu Gln Thr Tyr Val Ile Ser Ala Pro Lys Ile Phe Arg 
            20                  25                  30          


Val Gly Ala Ser Glu Asn Ile Val Ile Gln Val Tyr Gly Tyr Thr Glu 
        35                  40                  45              


Ala Phe Asp Ala Thr Ile Ser Ile Lys Ser Tyr Pro Asp Lys Lys Phe 
    50                  55                  60                  


Ser Tyr Ser Ser Gly His Val His Leu Ser Ser Glu Asn Lys Phe Gln 
65                  70                  75                  80  


Asn Ser Ala Ile Leu Thr Ile Gln Pro Lys Gln Leu Pro Gly Gly Gln 
                85                  90                  95      


Asn Pro Val Ser Tyr Val Tyr Leu Glu Val Val Ser Lys His Phe Ser 
            100                 105                 110         


Lys Ser Lys Arg Met Pro Ile Thr Tyr Asp Asn Gly Phe Leu Phe Ile 
        115                 120                 125             


His Thr Asp Lys Pro Val Tyr Thr Pro Asp Gln Ser Val Lys Val Arg 
    130                 135                 140                 


Val Tyr Ser Leu Asn Asp Asp Leu Lys Pro Ala Lys Arg Glu Thr Val 
145                 150                 155                 160 


Leu Thr Phe Ile Asp Pro Glu Gly Ser Glu Val Asp Met Val Glu Glu 
                165                 170                 175     


Ile Asp His Ile Gly Ile Ile Ser Phe Pro Asp Phe Lys Ile Pro Ser 
            180                 185                 190         


Asn Pro Arg Tyr Gly Met Trp Thr Ile Lys Ala Lys Tyr Lys Glu Asp 
        195                 200                 205             


Phe Ser Thr Thr Gly Thr Ala Tyr Phe Glu Val Lys Glu Tyr Val Leu 
    210                 215                 220                 


Pro His Phe Ser Val Ser Ile Glu Pro Glu Tyr Asn Phe Ile Gly Tyr 
225                 230                 235                 240 


Lys Asn Phe Lys Asn Phe Glu Ile Thr Ile Lys Ala Arg Tyr Phe Tyr 
                245                 250                 255     


Asn Lys Val Val Thr Glu Ala Asp Val Tyr Ile Thr Phe Gly Ile Arg 
            260                 265                 270         


Glu Asp Leu Lys Asp Asp Gln Lys Glu Met Met Gln Thr Ala Met Gln 
        275                 280                 285             


Asn Thr Met Leu Ile Asn Gly Ile Ala Gln Val Thr Phe Asp Ser Glu 
    290                 295                 300                 


Thr Ala Val Lys Glu Leu Ser Tyr Tyr Ser Leu Glu Asp Leu Asn Asn 
305                 310                 315                 320 


Lys Tyr Leu Tyr Ile Ala Val Thr Val Ile Glu Ser Thr Gly Gly Phe 
                325                 330                 335     


Ser Glu Glu Ala Glu Ile Pro Gly Ile Lys Tyr Val Leu Ser Pro Tyr 
            340                 345                 350         


Lys Leu Asn Leu Val Ala Thr Pro Leu Phe Leu Lys Pro Gly Ile Pro 
        355                 360                 365             


Tyr Pro Ile Lys Val Gln Val Lys Asp Ser Leu Asp Gln Leu Val Gly 
    370                 375                 380                 


Gly Val Pro Val Thr Leu Asn Ala Gln Thr Ile Asp Val Asn Gln Glu 
385                 390                 395                 400 


Thr Ser Asp Leu Asp Pro Ser Lys Ser Val Thr Arg Val Asp Asp Gly 
                405                 410                 415     


Val Ala Ser Phe Val Leu Asn Leu Pro Ser Gly Val Thr Val Leu Glu 
            420                 425                 430         


Phe Asn Val Lys Thr Asp Ala Pro Asp Leu Pro Glu Glu Asn Gln Ala 
        435                 440                 445             


Arg Glu Gly Tyr Arg Ala Ile Ala Tyr Ser Ser Leu Ser Gln Ser Tyr 
    450                 455                 460                 


Leu Tyr Ile Asp Trp Thr Asp Asn His Lys Ala Leu Leu Val Gly Glu 
465                 470                 475                 480 


His Leu Asn Ile Ile Val Thr Pro Lys Ser Pro Tyr Ile Asp Lys Ile 
                485                 490                 495     


Thr His Tyr Asn Tyr Leu Ile Leu Ser Lys Gly Lys Ile Ile His Phe 
            500                 505                 510         


Gly Thr Arg Glu Lys Phe Ser Asp Ala Ser Tyr Gln Ser Ile Asn Ile 
        515                 520                 525             


Pro Val Thr Gln Asn Met Val Pro Ser Ser Arg Leu Leu Val Tyr Tyr 
    530                 535                 540                 


Ile Val Thr Gly Glu Gln Thr Ala Glu Leu Val Ser Asp Ser Val Trp 
545                 550                 555                 560 


Leu Asn Ile Glu Glu Lys Cys Gly Asn Gln Leu Gln Val His Leu Ser 
                565                 570                 575     


Pro Asp Ala Asp Ala Tyr Ser Pro Gly Gln Thr Val Ser Leu Asn Met 
            580                 585                 590         


Ala Thr Gly Met Asp Ser Trp Val Ala Leu Ala Ala Val Asp Ser Ala 
        595                 600                 605             


Val Tyr Gly Val Gln Arg Gly Ala Lys Lys Pro Leu Glu Arg Val Phe 
    610                 615                 620                 


Gln Phe Leu Glu Lys Ser Asp Leu Gly Cys Gly Ala Gly Gly Gly Leu 
625                 630                 635                 640 


Asn Asn Ala Asn Val Phe His Leu Ala Gly Leu Thr Phe Leu Thr Asn 
                645                 650                 655     


Ala Asn Ala Asp Asp Ser Gln Glu Asn Asp Glu Pro Cys Lys Glu Ile 
            660                 665                 670         


Leu Arg Pro Arg Arg Thr Leu Gln Lys Lys Ile Glu Glu Ile Ala Ala 
        675                 680                 685             


Lys Tyr Lys His Ser Val Val Lys Lys Cys Cys Tyr Asp Gly Ala Cys 
    690                 695                 700                 


Val Asn Asn Asp Glu Thr Cys Glu Gln Arg Ala Ala Arg Ile Ser Leu 
705                 710                 715                 720 


Gly Pro Arg Cys Ile Lys Ala Phe Thr Glu Cys Cys Val Val Ala Ser 
                725                 730                 735     


Gln Leu Arg Ala Asn Ile Ser His Lys Asp Met Gln Leu Gly Arg Leu 
            740                 745                 750         


His Met Lys Thr Leu Leu Pro Val Ser Lys Pro Glu Ile Arg Ser Tyr 
        755                 760                 765             


Phe Pro Glu Ser Trp Leu Trp Glu Val His Leu Val Pro Arg Arg Lys 
    770                 775                 780                 


Gln Leu Gln Phe Ala Leu Pro Asp Ser Leu Thr Thr Trp Glu Ile Gln 
785                 790                 795                 800 


Gly Val Gly Ile Ser Asn Thr Gly Ile Cys Val Ala Asp Thr Val Lys 
                805                 810                 815     


Ala Lys Val Phe Lys Asp Val Phe Leu Glu Met Asn Ile Pro Tyr Ser 
            820                 825                 830         


Val Val Arg Gly Glu Gln Ile Gln Leu Lys Gly Thr Val Tyr Asn Tyr 
        835                 840                 845             


Arg Thr Ser Gly Met Gln Phe Cys Val Lys Met Ser Ala Val Glu Gly 
    850                 855                 860                 


Ile Cys Thr Ser Glu Ser Pro Val Ile Asp His Gln Gly Thr Lys Ser 
865                 870                 875                 880 


Ser Lys Cys Val Arg Gln Lys Val Glu Gly Ser Ser Ser His Leu Val 
                885                 890                 895     


Thr Phe Thr Val Leu Pro Leu Glu Ile Gly Leu His Asn Ile Asn Phe 
            900                 905                 910         


Ser Leu Glu Thr Trp Phe Gly Lys Glu Ile Leu Val Lys Thr Leu Arg 
        915                 920                 925             


Val Val Pro Glu Gly Val Lys Arg Glu Ser Tyr Ser Gly Val Thr Leu 
    930                 935                 940                 


Asp Pro Arg Gly Ile Tyr Gly Thr Ile Ser Arg Arg Lys Glu Phe Pro 
945                 950                 955                 960 


Tyr Arg Ile Pro Leu Asp Leu Val Pro Lys Thr Glu Ile Lys Arg Ile 
                965                 970                 975     


Leu Ser Val Lys Gly Leu Leu Val Gly Glu Ile Leu Ser Ala Val Leu 
            980                 985                 990         


Ser Gln Glu Gly Ile Asn Ile Leu  Thr His Leu Pro Lys  Gly Ser Ala 
        995                 1000                 1005             


Glu Ala  Glu Leu Met Ser Val  Val Pro Val Phe Tyr  Val Phe His 
    1010                 1015                 1020             


Tyr Leu  Glu Thr Gly Asn His  Trp Asn Ile Phe His  Ser Asp Pro 
    1025                 1030                 1035             


Leu Ile  Glu Lys Gln Lys Leu  Lys Lys Lys Leu Lys  Glu Gly Met 
    1040                 1045                 1050             


Leu Ser  Ile Met Ser Tyr Arg  Asn Ala Asp Tyr Ser  Tyr Ser Val 
    1055                 1060                 1065             


Trp Lys  Gly Gly Ser Ala Ser  Thr Trp Leu Thr Ala  Phe Ala Leu 
    1070                 1075                 1080             


Arg Val  Leu Gly Gln Val Asn  Lys Tyr Val Glu Gln  Asn Gln Asn 
    1085                 1090                 1095             


Ser Ile  Cys Asn Ser Leu Leu  Trp Leu Val Glu Asn  Tyr Gln Leu 
    1100                 1105                 1110             


Asp Asn  Gly Ser Phe Lys Glu  Asn Ser Gln Tyr Gln  Pro Ile Lys 
    1115                 1120                 1125             


Leu Gln  Gly Thr Leu Pro Val  Glu Ala Arg Glu Asn  Ser Leu Tyr 
    1130                 1135                 1140             


Leu Thr  Ala Phe Thr Val Ile  Gly Ile Arg Lys Ala  Phe Asp Ile 
    1145                 1150                 1155             


Cys Pro  Leu Val Lys Ile Asp  Thr Ala Leu Ile Lys  Ala Asp Asn 
    1160                 1165                 1170             


Phe Leu  Leu Glu Asn Thr Leu  Pro Ala Gln Ser Thr  Phe Thr Leu 
    1175                 1180                 1185             


Ala Ile  Ser Ala Tyr Ala Leu  Ser Leu Gly Asp Lys  Thr His Pro 
    1190                 1195                 1200             


Gln Phe  Arg Ser Ile Val Ser  Ala Leu Lys Arg Glu  Ala Leu Val 
    1205                 1210                 1215             


Lys Gly  Asn Pro Pro Ile Tyr  Arg Phe Trp Lys Asp  Asn Leu Gln 
    1220                 1225                 1230             


His Lys  Asp Ser Ser Val Pro  Asn Thr Gly Thr Ala  Arg Met Val 
    1235                 1240                 1245             


Glu Thr  Thr Ala Tyr Ala Leu  Leu Thr Ser Leu Asn  Leu Lys Asp 
    1250                 1255                 1260             


Ile Asn  Tyr Val Asn Pro Val  Ile Lys Trp Leu Ser  Glu Glu Gln 
    1265                 1270                 1275             


Arg Tyr  Gly Gly Gly Phe Tyr  Ser Thr Gln Asp Thr  Ile Asn Ala 
    1280                 1285                 1290             


Ile Glu  Gly Leu Thr Glu Tyr  Ser Leu Leu Val Lys  Gln Leu Arg 
    1295                 1300                 1305             


Leu Ser  Met Asp Ile Asp Val  Ser Tyr Lys His Lys  Gly Ala Leu 
    1310                 1315                 1320             


His Asn  Tyr Lys Met Thr Asp  Lys Asn Phe Leu Gly  Arg Pro Val 
    1325                 1330                 1335             


Glu Val  Leu Leu Asn Asp Asp  Leu Ile Val Ser Thr  Gly Phe Gly 
    1340                 1345                 1350             


Ser Gly  Leu Ala Thr Val His  Val Thr Thr Val Val  His Lys Thr 
    1355                 1360                 1365             


Ser Thr  Ser Glu Glu Val Cys  Ser Phe Tyr Leu Lys  Ile Asp Thr 
    1370                 1375                 1380             


Gln Asp  Ile Glu Ala Ser His  Tyr Arg Gly Tyr Gly  Asn Ser Asp 
    1385                 1390                 1395             


Tyr Lys  Arg Ile Val Ala Cys  Ala Ser Tyr Lys Pro  Ser Arg Glu 
    1400                 1405                 1410             


Glu Ser  Ser Ser Gly Ser Ser  His Ala Val Met Asp  Ile Ser Leu 
    1415                 1420                 1425             


Pro Thr  Gly Ile Ser Ala Asn  Glu Glu Asp Leu Lys  Ala Leu Val 
    1430                 1435                 1440             


Glu Gly  Val Asp Gln Leu Phe  Thr Asp Tyr Gln Ile  Lys Asp Gly 
    1445                 1450                 1455             


His Val  Ile Leu Gln Leu Asn  Ser Ile Pro Ser Ser  Asp Phe Leu 
    1460                 1465                 1470             


Cys Val  Arg Phe Arg Ile Phe  Glu Leu Phe Glu Val  Gly Phe Leu 
    1475                 1480                 1485             


Ser Pro  Ala Thr Phe Thr Val  Tyr Glu Tyr His Arg  Pro Asp Lys 
    1490                 1495                 1500             


Gln Cys  Thr Met Phe Tyr Ser  Thr Ser Asn Ile Lys  Ile Gln Lys 
    1505                 1510                 1515             


Val Cys  Glu Gly Ala Ala Cys  Lys Cys Val Glu Ala  Asp Cys Gly 
    1520                 1525                 1530             


Gln Met  Gln Glu Glu Leu Asp  Leu Thr Ile Ser Ala  Glu Thr Arg 
    1535                 1540                 1545             


Lys Gln  Thr Ala Cys Lys Pro  Glu Ile Ala Tyr Ala  Tyr Lys Val 
    1550                 1555                 1560             


Ser Ile  Thr Ser Ile Thr Val  Glu Asn Val Phe Val  Lys Tyr Lys 
    1565                 1570                 1575             


Ala Thr  Leu Leu Asp Ile Tyr  Lys Thr Gly Glu Ala  Val Ala Glu 
    1580                 1585                 1590             


Lys Asp  Ser Glu Ile Thr Phe  Ile Lys Lys Val Thr  Cys Thr Asn 
    1595                 1600                 1605             


Ala Glu  Leu Val Lys Gly Arg  Gln Tyr Leu Ile Met  Gly Lys Glu 
    1610                 1615                 1620             


Ala Leu  Gln Ile Lys Tyr Asn  Phe Ser Phe Arg Tyr  Ile Tyr Pro 
    1625                 1630                 1635             


Leu Asp  Ser Leu Thr Trp Ile  Glu Tyr Trp Pro Arg  Asp Thr Thr 
    1640                 1645                 1650             


Cys Ser  Ser Cys Gln Ala Phe  Leu Ala Asn Leu Asp  Glu Phe Ala 
    1655                 1660                 1665             


Glu Asp  Ile Phe Leu Asn Gly  Cys 
    1670                 1675     


<210>  1914
<211>  72
<212>  PRT
<213>  Homo Sapiens

<400>  1914

Met Ala Val Ser Val Leu Arg Leu Thr Val Val Leu Gly Leu Leu Val 
1               5                   10                  15      


Leu Phe Leu Thr Cys Tyr Ala Asp Asp Lys Pro Asp Lys Pro Asp Asp 
            20                  25                  30          


Lys Pro Asp Asp Ser Gly Lys Asp Pro Lys Pro Asp Phe Pro Lys Phe 
        35                  40                  45              


Leu Ser Leu Leu Gly Thr Glu Ile Ile Glu Asn Ala Val Glu Phe Ile 
    50                  55                  60                  


Leu Arg Ser Met Ser Arg Ser Thr 
65                  70          


<210>  1915
<211>  87
<212>  PRT
<213>  Homo Sapiens

<400>  1915

Met Ala Val Ser Val Leu Arg Leu Thr Val Val Leu Gly Leu Leu Val 
1               5                   10                  15      


Leu Phe Leu Thr Cys Tyr Ala Asp Asp Lys Pro Asp Lys Pro Asp Asp 
            20                  25                  30          


Lys Pro Asp Asp Ser Gly Lys Asp Pro Lys Pro Asp Phe Pro Lys Phe 
        35                  40                  45              


Leu Ser Leu Leu Gly Thr Glu Ile Ile Glu Asn Ala Val Glu Phe Ile 
    50                  55                  60                  


Leu Arg Ser Met Ser Arg Ser Thr Gly Phe Met Glu Phe Asp Asp Asn 
65                  70                  75                  80  


Glu Gly Lys His Ser Ser Lys 
                85          


<210>  1916
<211>  31
<212>  PRT
<213>  Homo Sapiens

<400>  1916

Met Ala Arg Arg Ser Val Leu Tyr Phe Ile Leu Leu Asn Ala Leu Ile 
1               5                   10                  15      


Asn Lys Gly Gln Ala Cys Phe Cys Asp His Tyr Ala Trp Thr Gln 
            20                  25                  30      


<210>  1917
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  1917

Met Ala Arg Arg Ser Val Leu Tyr Phe Ile Leu Leu Asn Ala Leu Ile 
1               5                   10                  15      


Asn Lys Gly Gln Ala Cys Phe Cys Asp His Tyr Ala Trp Thr Gln Trp 
            20                  25                  30          


Thr Ser Cys Ser Lys Thr Cys Asn Ser Gly Thr Gln Ser Arg His Arg 
        35                  40                  45              


Gln Ile Val Val Asp Lys Tyr Tyr Gln Glu Asn Phe Cys Glu Gln Ile 
    50                  55                  60                  


Cys Ser Lys Gln Glu Thr Arg Glu Cys Asn Trp Gln Arg Cys Pro Ile 
65                  70                  75                  80  


Asn Cys Leu Leu Gly Asp Phe Gly Pro Trp Ser Asp Cys Asp Pro Cys 
                85                  90                  95      


Ile Glu Lys Gln Ser Lys Val Arg Ser Val Leu Arg Pro Ser Gln Phe 
            100                 105                 110         


Gly Gly Gln Pro Cys Thr Ala Pro Leu Val Ala Phe Gln Pro Cys Ile 
        115                 120                 125             


Pro Ser Lys Leu Cys 
    130             


<210>  1918
<211>  934
<212>  PRT
<213>  Homo Sapiens

<400>  1918

Met Ala Arg Arg Ser Val Leu Tyr Phe Ile Leu Leu Asn Ala Leu Ile 
1               5                   10                  15      


Asn Lys Gly Gln Ala Cys Phe Cys Asp His Tyr Ala Trp Thr Gln Trp 
            20                  25                  30          


Thr Ser Cys Ser Lys Thr Cys Asn Ser Gly Thr Gln Ser Arg His Arg 
        35                  40                  45              


Gln Ile Val Val Asp Lys Tyr Tyr Gln Glu Asn Phe Cys Glu Gln Ile 
    50                  55                  60                  


Cys Ser Lys Gln Glu Thr Arg Glu Cys Asn Trp Gln Arg Cys Pro Ile 
65                  70                  75                  80  


Asn Cys Leu Leu Gly Asp Phe Gly Pro Trp Ser Asp Cys Asp Pro Cys 
                85                  90                  95      


Ile Glu Lys Gln Ser Lys Val Arg Ser Val Leu Arg Pro Ser Gln Phe 
            100                 105                 110         


Gly Gly Gln Pro Cys Thr Ala Pro Leu Val Ala Phe Gln Pro Cys Ile 
        115                 120                 125             


Pro Ser Lys Leu Cys Lys Ile Glu Glu Ala Asp Cys Lys Asn Lys Phe 
    130                 135                 140                 


Arg Cys Asp Ser Gly Arg Cys Ile Ala Arg Lys Leu Glu Cys Asn Gly 
145                 150                 155                 160 


Glu Asn Asp Cys Gly Asp Asn Ser Asp Glu Arg Asp Cys Gly Arg Thr 
                165                 170                 175     


Lys Ala Val Cys Thr Arg Lys Tyr Asn Pro Ile Pro Ser Val Gln Leu 
            180                 185                 190         


Met Gly Asn Gly Phe His Phe Leu Ala Gly Glu Pro Arg Gly Glu Val 
        195                 200                 205             


Leu Asp Asn Ser Phe Thr Gly Gly Ile Cys Lys Thr Val Lys Ser Ser 
    210                 215                 220                 


Arg Thr Ser Asn Pro Tyr Arg Val Pro Ala Asn Leu Glu Asn Val Gly 
225                 230                 235                 240 


Phe Glu Val Gln Thr Ala Glu Asp Asp Leu Lys Thr Asp Phe Tyr Lys 
                245                 250                 255     


Asp Leu Thr Ser Leu Gly His Asn Glu Asn Gln Gln Gly Ser Phe Ser 
            260                 265                 270         


Ser Gln Gly Gly Ser Ser Phe Ser Val Pro Ile Phe Tyr Ser Ser Lys 
        275                 280                 285             


Arg Ser Glu Asn Ile Asn His Asn Ser Ala Phe Lys Gln Ala Ile Gln 
    290                 295                 300                 


Ala Ser His Lys Lys Asp Ser Ser Phe Ile Arg Ile His Lys Val Met 
305                 310                 315                 320 


Lys Val Leu Asn Phe Thr Thr Lys Ala Lys Asp Leu His Leu Ser Asp 
                325                 330                 335     


Val Phe Leu Lys Ala Leu Asn His Leu Pro Leu Glu Tyr Asn Ser Ala 
            340                 345                 350         


Leu Tyr Ser Arg Ile Phe Asp Asp Phe Gly Thr His Tyr Phe Thr Ser 
        355                 360                 365             


Gly Ser Leu Gly Gly Val Tyr Asp Leu Leu Tyr Gln Phe Ser Ser Glu 
    370                 375                 380                 


Glu Leu Lys Asn Ser Gly Leu Thr Glu Glu Glu Ala Lys His Cys Val 
385                 390                 395                 400 


Arg Ile Glu Thr Lys Lys Arg Val Leu Phe Ala Lys Lys Thr Lys Val 
                405                 410                 415     


Glu His Arg Cys Thr Thr Asn Lys Leu Ser Glu Lys His Glu Gly Ser 
            420                 425                 430         


Phe Ile Gln Gly Ala Glu Lys Ser Ile Ser Leu Ile Arg Gly Gly Arg 
        435                 440                 445             


Ser Glu Tyr Gly Ala Ala Leu Ala Trp Glu Lys Gly Ser Ser Gly Leu 
    450                 455                 460                 


Glu Glu Lys Thr Phe Ser Glu Trp Leu Glu Ser Val Lys Glu Asn Pro 
465                 470                 475                 480 


Ala Val Ile Asp Phe Glu Leu Ala Pro Ile Val Asp Leu Val Arg Asn 
                485                 490                 495     


Ile Pro Cys Ala Val Thr Lys Arg Asn Asn Leu Arg Lys Ala Leu Gln 
            500                 505                 510         


Glu Tyr Ala Ala Lys Phe Asp Pro Cys Gln Cys Ala Pro Cys Pro Asn 
        515                 520                 525             


Asn Gly Arg Pro Thr Leu Ser Gly Thr Glu Cys Leu Cys Val Cys Gln 
    530                 535                 540                 


Ser Gly Thr Tyr Gly Glu Asn Cys Glu Lys Gln Ser Pro Asp Tyr Lys 
545                 550                 555                 560 


Ser Asn Ala Val Asp Gly Gln Trp Gly Cys Trp Ser Ser Trp Ser Thr 
                565                 570                 575     


Cys Asp Ala Thr Tyr Lys Arg Ser Arg Thr Arg Glu Cys Asn Asn Pro 
            580                 585                 590         


Ala Pro Gln Arg Gly Gly Lys Arg Cys Glu Gly Glu Lys Arg Gln Glu 
        595                 600                 605             


Glu Asp Cys Thr Phe Ser Ile Met Glu Asn Asn Gly Gln Pro Cys Ile 
    610                 615                 620                 


Asn Asp Asp Glu Glu Met Lys Glu Val Asp Leu Pro Glu Ile Glu Ala 
625                 630                 635                 640 


Asp Ser Gly Cys Pro Gln Pro Val Pro Pro Glu Asn Gly Phe Ile Arg 
                645                 650                 655     


Asn Glu Lys Gln Leu Tyr Leu Val Gly Glu Asp Val Glu Ile Ser Cys 
            660                 665                 670         


Leu Thr Gly Phe Glu Thr Val Gly Tyr Gln Tyr Phe Arg Cys Leu Pro 
        675                 680                 685             


Asp Gly Thr Trp Arg Gln Gly Asp Val Glu Cys Gln Arg Thr Glu Cys 
    690                 695                 700                 


Ile Lys Pro Val Val Gln Glu Val Leu Thr Ile Thr Pro Phe Gln Arg 
705                 710                 715                 720 


Leu Tyr Arg Ile Gly Glu Ser Ile Glu Leu Thr Cys Pro Lys Gly Phe 
                725                 730                 735     


Val Val Ala Gly Pro Ser Arg Tyr Thr Cys Gln Gly Asn Ser Trp Thr 
            740                 745                 750         


Pro Pro Ile Ser Asn Ser Leu Thr Cys Glu Lys Asp Thr Leu Thr Lys 
        755                 760                 765             


Leu Lys Gly His Cys Gln Leu Gly Gln Lys Gln Ser Gly Ser Glu Cys 
    770                 775                 780                 


Ile Cys Met Ser Pro Glu Glu Asp Cys Ser His His Ser Glu Asp Leu 
785                 790                 795                 800 


Cys Val Phe Asp Thr Asp Ser Asn Asp Tyr Phe Thr Ser Pro Ala Cys 
                805                 810                 815     


Lys Phe Leu Ala Glu Lys Cys Leu Asn Asn Gln Gln Leu His Phe Leu 
            820                 825                 830         


His Ile Gly Ser Cys Gln Asp Gly Arg Gln Leu Glu Trp Gly Leu Glu 
        835                 840                 845             


Arg Thr Arg Leu Ser Ser Asn Ser Thr Lys Lys Glu Ser Cys Gly Tyr 
    850                 855                 860                 


Asp Thr Cys Tyr Asp Trp Glu Lys Cys Ser Ala Ser Thr Ser Lys Cys 
865                 870                 875                 880 


Val Cys Leu Leu Pro Pro Gln Cys Phe Lys Gly Gly Asn Gln Leu Tyr 
                885                 890                 895     


Cys Val Lys Met Gly Ser Ser Thr Ser Glu Lys Thr Leu Asn Ile Cys 
            900                 905                 910         


Glu Val Gly Thr Ile Arg Cys Ala Asn Arg Lys Met Glu Ile Leu His 
        915                 920                 925             


Pro Gly Lys Cys Leu Ala 
    930                 


<210>  1919
<211>  934
<212>  PRT
<213>  Homo Sapiens

<400>  1919

Met Ala Arg Arg Ser Val Leu Tyr Phe Ile Leu Leu Asn Ala Leu Ile 
1               5                   10                  15      


Asn Lys Gly Gln Ala Cys Phe Cys Asp His Tyr Ala Trp Thr Gln Trp 
            20                  25                  30          


Thr Ser Cys Ser Lys Thr Cys Asn Ser Gly Thr Gln Ser Arg His Arg 
        35                  40                  45              


Gln Ile Val Val Asp Lys Tyr Tyr Gln Glu Asn Phe Cys Glu Gln Ile 
    50                  55                  60                  


Cys Ser Lys Gln Glu Thr Arg Glu Cys Asn Trp Gln Arg Cys Pro Ile 
65                  70                  75                  80  


Asn Cys Leu Leu Gly Asp Phe Gly Pro Trp Ser Asp Cys Asp Pro Cys 
                85                  90                  95      


Ile Glu Lys Gln Ser Lys Val Arg Ser Val Leu Arg Pro Ser Gln Phe 
            100                 105                 110         


Gly Gly Gln Pro Cys Thr Ala Pro Leu Val Ala Phe Gln Pro Cys Ile 
        115                 120                 125             


Pro Ser Lys Leu Cys Lys Ile Glu Glu Ala Asp Cys Lys Asn Lys Phe 
    130                 135                 140                 


Arg Cys Asp Ser Gly Arg Cys Ile Ala Arg Lys Leu Glu Cys Asn Gly 
145                 150                 155                 160 


Glu Asn Asp Cys Gly Asp Asn Ser Asp Glu Arg Asp Cys Gly Arg Thr 
                165                 170                 175     


Lys Ala Val Cys Thr Arg Lys Tyr Asn Pro Ile Pro Ser Val Gln Leu 
            180                 185                 190         


Met Gly Asn Gly Phe His Phe Leu Ala Gly Glu Pro Arg Gly Glu Val 
        195                 200                 205             


Leu Asp Asn Ser Phe Thr Gly Gly Ile Cys Lys Thr Val Lys Ser Ser 
    210                 215                 220                 


Arg Thr Ser Asn Pro Tyr Arg Val Pro Ala Asn Leu Glu Asn Val Gly 
225                 230                 235                 240 


Phe Glu Val Gln Thr Ala Glu Asp Asp Leu Lys Thr Asp Phe Tyr Lys 
                245                 250                 255     


Asp Leu Thr Ser Leu Gly His Asn Glu Asn Gln Gln Gly Ser Phe Ser 
            260                 265                 270         


Ser Gln Gly Gly Ser Ser Phe Ser Val Pro Ile Phe Tyr Ser Ser Lys 
        275                 280                 285             


Arg Ser Glu Asn Ile Asn His Asn Ser Ala Phe Lys Gln Ala Ile Gln 
    290                 295                 300                 


Ala Ser His Lys Lys Asp Ser Ser Phe Ile Arg Ile His Lys Val Met 
305                 310                 315                 320 


Lys Val Leu Asn Phe Thr Thr Lys Ala Lys Asp Leu His Leu Ser Asp 
                325                 330                 335     


Val Phe Leu Lys Ala Leu Asn His Leu Pro Leu Glu Tyr Asn Ser Ala 
            340                 345                 350         


Leu Tyr Ser Arg Ile Phe Asp Asp Phe Gly Thr His Tyr Phe Thr Ser 
        355                 360                 365             


Gly Ser Leu Gly Gly Val Tyr Asp Leu Leu Tyr Gln Phe Ser Ser Glu 
    370                 375                 380                 


Glu Leu Lys Asn Ser Gly Leu Thr Glu Glu Glu Ala Lys His Cys Val 
385                 390                 395                 400 


Arg Ile Glu Thr Lys Lys Arg Val Leu Phe Ala Lys Lys Thr Lys Val 
                405                 410                 415     


Glu His Arg Cys Thr Thr Asn Lys Leu Ser Glu Lys His Glu Gly Ser 
            420                 425                 430         


Phe Ile Gln Gly Ala Glu Lys Ser Ile Ser Leu Ile Arg Gly Gly Arg 
        435                 440                 445             


Ser Glu Tyr Gly Ala Ala Leu Ala Trp Glu Lys Gly Ser Ser Gly Leu 
    450                 455                 460                 


Glu Glu Lys Thr Phe Ser Glu Trp Leu Glu Ser Val Lys Glu Asn Pro 
465                 470                 475                 480 


Ala Val Ile Asp Phe Glu Leu Ala Pro Ile Val Asp Leu Val Arg Asn 
                485                 490                 495     


Ile Pro Cys Ala Val Thr Lys Arg Asn Asn Leu Arg Lys Ala Leu Gln 
            500                 505                 510         


Glu Tyr Ala Ala Lys Phe Asp Pro Cys Gln Cys Ala Pro Cys Pro Asn 
        515                 520                 525             


Asn Gly Arg Pro Thr Leu Ser Gly Thr Glu Cys Leu Cys Val Cys Gln 
    530                 535                 540                 


Ser Gly Thr Tyr Gly Glu Asn Cys Glu Lys Gln Ser Pro Asp Tyr Lys 
545                 550                 555                 560 


Ser Asn Ala Val Asp Gly Gln Trp Gly Cys Trp Ser Ser Trp Ser Thr 
                565                 570                 575     


Cys Asp Ala Thr Tyr Lys Arg Ser Arg Thr Arg Glu Cys Asn Asn Pro 
            580                 585                 590         


Ala Pro Gln Arg Gly Gly Lys Arg Cys Glu Gly Glu Lys Arg Gln Glu 
        595                 600                 605             


Glu Asp Cys Thr Phe Ser Ile Met Glu Asn Asn Gly Gln Pro Cys Ile 
    610                 615                 620                 


Asn Asp Asp Glu Glu Met Lys Glu Val Asp Leu Pro Glu Ile Glu Ala 
625                 630                 635                 640 


Asp Ser Gly Cys Pro Gln Pro Val Pro Pro Glu Asn Gly Phe Ile Arg 
                645                 650                 655     


Asn Glu Lys Gln Leu Tyr Leu Val Gly Glu Asp Val Glu Ile Ser Cys 
            660                 665                 670         


Leu Thr Gly Phe Glu Thr Val Gly Tyr Gln Tyr Phe Arg Cys Leu Pro 
        675                 680                 685             


Asp Gly Thr Trp Arg Gln Gly Asp Val Glu Cys Gln Arg Thr Glu Cys 
    690                 695                 700                 


Ile Lys Pro Val Val Gln Glu Val Leu Thr Ile Thr Pro Phe Gln Arg 
705                 710                 715                 720 


Leu Tyr Arg Ile Gly Glu Ser Ile Glu Leu Thr Cys Pro Lys Gly Phe 
                725                 730                 735     


Val Val Ala Gly Pro Ser Arg Tyr Thr Cys Gln Gly Asn Ser Trp Thr 
            740                 745                 750         


Pro Pro Ile Ser Asn Ser Leu Thr Cys Glu Lys Asp Thr Leu Thr Lys 
        755                 760                 765             


Leu Lys Gly His Cys Gln Leu Gly Gln Lys Gln Ser Gly Ser Glu Cys 
    770                 775                 780                 


Ile Cys Met Ser Pro Glu Glu Asp Cys Ser His His Ser Glu Asp Leu 
785                 790                 795                 800 


Cys Val Phe Asp Thr Asp Ser Asn Asp Tyr Phe Thr Ser Pro Ala Cys 
                805                 810                 815     


Lys Phe Leu Ala Glu Lys Cys Leu Asn Asn Gln Gln Leu His Phe Leu 
            820                 825                 830         


His Ile Gly Ser Cys Gln Asp Gly Arg Gln Leu Glu Trp Gly Leu Glu 
        835                 840                 845             


Arg Thr Arg Leu Ser Ser Asn Ser Thr Lys Lys Glu Ser Cys Gly Tyr 
    850                 855                 860                 


Asp Thr Cys Tyr Asp Trp Glu Lys Cys Ser Ala Ser Thr Ser Lys Cys 
865                 870                 875                 880 


Val Cys Leu Leu Pro Pro Gln Cys Phe Lys Gly Gly Asn Gln Leu Tyr 
                885                 890                 895     


Cys Val Lys Met Gly Ser Ser Thr Ser Glu Lys Thr Leu Asn Ile Cys 
            900                 905                 910         


Glu Val Gly Thr Ile Arg Cys Ala Asn Arg Lys Met Glu Ile Leu His 
        915                 920                 925             


Pro Gly Lys Cys Leu Ala 
    930                 


<210>  1920
<211>  191
<212>  PRT
<213>  Homo Sapiens

<400>  1920

Met Ala Ala Pro Arg Gly Arg Ala Ala Pro Trp Thr Thr Ala Leu Leu 
1               5                   10                  15      


Leu Leu Leu Ala Ser Gln Val Leu Ser Pro Gly Ser Cys Ala Asp Glu 
            20                  25                  30          


Glu Glu Val Pro Glu Glu Trp Val Leu Leu His Val Val Gln Gly Gln 
        35                  40                  45              


Ile Gly Ala Gly Asn Tyr Ser Tyr Leu Arg Leu Asn His Glu Gly Lys 
    50                  55                  60                  


Ile Val Leu Arg Met Arg Ser Leu Lys Gly Asp Ala Asp Leu Tyr Val 
65                  70                  75                  80  


Ser Ala Ser Ser Leu His Pro Ser Phe Asp Asp Tyr Glu Leu Gln Ser 
                85                  90                  95      


Ala Thr Cys Gly Pro Asp Ala Val Ser Ile Pro Ala His Phe Arg Arg 
            100                 105                 110         


Pro Val Gly Ile Gly Val Tyr Gly His Pro Ser His Leu Glu Ser Glu 
        115                 120                 125             


Phe Glu Met Lys Val Tyr Tyr Asp Gly Thr Val Glu Gln His Pro Phe 
    130                 135                 140                 


Gly Glu Ala Ala Tyr Pro Ala Asp Gly Ala Asp Ala Gly Gln Lys His 
145                 150                 155                 160 


Ala Gly Ala Pro Glu Asp Ala Ser Gln Glu Glu Glu Ser Val Leu Trp 
                165                 170                 175     


Thr Ile Leu Ile Ser Ile Leu Lys Leu Val Leu Glu Ile Leu Phe 
            180                 185                 190     


<210>  1921
<211>  325
<212>  PRT
<213>  Homo Sapiens

<400>  1921

Met Gln Gly Arg Val Ala Gly Ser Cys Ala Pro Leu Gly Leu Leu Leu 
1               5                   10                  15      


Val Cys Leu His Leu Pro Gly Leu Phe Ala Arg Ser Ile Gly Val Val 
            20                  25                  30          


Glu Glu Lys Val Ser Gln Asn Leu Gly Thr Asn Leu Pro Gln Leu Gly 
        35                  40                  45              


Gln Pro Ser Ser Thr Gly Pro Ser Asn Ser Glu His Pro Gln Pro Ala 
    50                  55                  60                  


Leu Asp Pro Arg Ser Asn Asp Leu Ala Arg Val Pro Leu Lys Leu Ser 
65                  70                  75                  80  


Val Pro Ala Ser Asp Gly Phe Pro Pro Ala Gly Gly Ser Ala Val Gln 
                85                  90                  95      


Arg Trp Pro Pro Ser Trp Gly Leu Pro Ala Met Asp Ser Trp Pro Pro 
            100                 105                 110         


Glu Asp Pro Trp Gln Met Met Ala Ala Ala Ala Glu Asp Arg Leu Gly 
        115                 120                 125             


Glu Ala Leu Pro Glu Glu Leu Ser Tyr Leu Ser Ser Ala Ala Ala Leu 
    130                 135                 140                 


Ala Pro Gly Ser Gly Pro Leu Pro Gly Glu Ser Ser Pro Asp Ala Thr 
145                 150                 155                 160 


Gly Leu Ser Pro Lys Ala Ser Leu Leu His Gln Asp Ser Glu Ser Arg 
                165                 170                 175     


Arg Leu Pro Arg Ser Asn Ser Leu Gly Ala Gly Gly Lys Ile Leu Ser 
            180                 185                 190         


Gln Arg Pro Pro Trp Ser Leu Ile His Arg Val Leu Pro Asp His Pro 
        195                 200                 205             


Trp Gly Thr Leu Asn Pro Ser Val Ser Trp Gly Gly Gly Gly Pro Gly 
    210                 215                 220                 


Thr Gly Trp Gly Thr Arg Pro Met Pro His Pro Glu Gly Ile Trp Gly 
225                 230                 235                 240 


Ile Asn Asn Gln Pro Pro Gly Thr Ser Trp Gly Asn Ile Asn Arg Tyr 
                245                 250                 255     


Pro Gly Gly Ser Trp Gly Asn Ile Asn Arg Tyr Pro Gly Gly Ser Trp 
            260                 265                 270         


Gly Asn Ile Asn Arg Tyr Pro Gly Gly Ser Trp Gly Asn Ile His Leu 
        275                 280                 285             


Tyr Pro Gly Ile Asn Asn Pro Phe Pro Pro Gly Val Leu Arg Pro Pro 
    290                 295                 300                 


Gly Ser Ser Trp Asn Ile Pro Ala Gly Phe Pro Asn Pro Pro Ser Pro 
305                 310                 315                 320 


Arg Leu Gln Trp Gly 
                325 


<210>  1922
<211>  330
<212>  PRT
<213>  Homo Sapiens

<400>  1922

Met Ala Phe Leu Pro Ser Trp Val Cys Val Leu Val Gly Ser Phe Ser 
1               5                   10                  15      


Ala Ser Leu Ala Gly Thr Ser Asn Leu Ser Glu Thr Glu Pro Pro Leu 
            20                  25                  30          


Trp Lys Glu Ser Pro Gly Gln Leu Ser Asp Tyr Arg Val Glu Asn Ser 
        35                  40                  45              


Met Tyr Ile Ile Asn Pro Trp Val Tyr Leu Glu Arg Met Gly Met Tyr 
    50                  55                  60                  


Lys Ile Ile Leu Asn Gln Thr Ala Arg Tyr Phe Ala Lys Phe Ala Pro 
65                  70                  75                  80  


Asp Asn Glu Gln Asn Ile Leu Trp Gly Leu Pro Leu Gln Tyr Gly Trp 
                85                  90                  95      


Gln Tyr Arg Thr Gly Arg Leu Ala Asp Pro Thr Arg Arg Thr Asn Cys 
            100                 105                 110         


Gly Tyr Glu Ser Gly Asp His Met Cys Ile Ser Val Asp Ser Trp Trp 
        115                 120                 125             


Ala Asp Leu Asn Tyr Phe Leu Ser Ser Leu Pro Phe Leu Ala Ala Val 
    130                 135                 140                 


Asp Ser Gly Val Met Gly Ile Ser Ser Asp Gln Val Arg Leu Leu Pro 
145                 150                 155                 160 


Pro Pro Lys Asn Glu Arg Lys Phe Cys Tyr Asp Val Ser Ser Cys Arg 
                165                 170                 175     


Ser Ser Phe Pro Glu Thr Met Asn Lys Trp Asn Thr Phe Tyr Gln Tyr 
            180                 185                 190         


Leu Gln Ser Pro Phe Ser Lys Phe Asp Asp Leu Leu Lys Tyr Leu Trp 
        195                 200                 205             


Ala Ala His Thr Ser Thr Leu Ala Asp Asn Ile Lys Ser Phe Glu Asp 
    210                 215                 220                 


Arg Tyr Asp Tyr Tyr Ser Lys Ala Glu Ala His Phe Glu Arg Ser Trp 
225                 230                 235                 240 


Val Leu Ala Val Asp His Leu Ala Ala Val Leu Phe Pro Thr Thr Leu 
                245                 250                 255     


Ile Arg Ser Tyr Lys Phe Gln Lys Gly Met Pro Pro Arg Ile Leu Leu 
            260                 265                 270         


Asn Thr Asp Val Ala Pro Phe Ile Ser Asp Phe Thr Ala Phe Gln Asn 
        275                 280                 285             


Val Val Leu Val Leu Leu Asn Met Leu Asp Asn Val Asp Lys Ser Ile 
    290                 295                 300                 


Gly Tyr Leu Cys Thr Glu Lys Ser Asn Val Tyr Arg Asp His Ser Glu 
305                 310                 315                 320 


Ser Ser Ser Arg Ser Tyr Gly Asn Asn Ser 
                325                 330 


<210>  1923
<211>  843
<212>  PRT
<213>  Homo Sapiens

<400>  1923

Met Lys Val Ile Ser Leu Phe Ile Leu Val Gly Phe Ile Gly Glu Phe 
1               5                   10                  15      


Gln Ser Phe Ser Ser Ala Ser Ser Pro Val Asn Cys Gln Trp Asp Phe 
            20                  25                  30          


Tyr Ala Pro Trp Ser Glu Cys Asn Gly Cys Thr Lys Thr Gln Thr Arg 
        35                  40                  45              


Arg Arg Ser Val Ala Val Tyr Gly Gln Tyr Gly Gly Gln Pro Cys Val 
    50                  55                  60                  


Gly Asn Ala Phe Glu Thr Gln Ser Cys Glu Pro Thr Arg Gly Cys Pro 
65                  70                  75                  80  


Thr Glu Glu Gly Cys Gly Glu Arg Phe Arg Cys Phe Ser Gly Gln Cys 
                85                  90                  95      


Ile Ser Lys Ser Leu Val Cys Asn Gly Asp Ser Asp Cys Asp Glu Asp 
            100                 105                 110         


Ser Ala Asp Glu Asp Arg Cys Glu Asp Ser Glu Arg Arg Pro Ser Cys 
        115                 120                 125             


Asp Ile Asp Lys Pro Pro Pro Asn Ile Glu Leu Thr Gly Asn Gly Tyr 
    130                 135                 140                 


Asn Glu Leu Thr Gly Gln Phe Arg Asn Arg Val Ile Asn Thr Lys Ser 
145                 150                 155                 160 


Phe Gly Gly Gln Cys Arg Lys Val Phe Ser Gly Asp Gly Lys Asp Phe 
                165                 170                 175     


Tyr Arg Leu Ser Gly Asn Val Leu Ser Tyr Thr Phe Gln Val Lys Ile 
            180                 185                 190         


Asn Asn Asp Phe Asn Tyr Glu Phe Tyr Asn Ser Thr Trp Ser Tyr Val 
        195                 200                 205             


Lys His Thr Ser Thr Glu His Thr Ser Ser Ser Arg Lys Arg Ser Phe 
    210                 215                 220                 


Phe Arg Ser Ser Ser Ser Ser Ser Arg Ser Tyr Thr Ser His Thr Asn 
225                 230                 235                 240 


Glu Ile His Lys Gly Lys Ser Tyr Gln Leu Leu Val Val Glu Asn Thr 
                245                 250                 255     


Val Glu Val Ala Gln Phe Ile Asn Asn Asn Pro Glu Phe Leu Gln Leu 
            260                 265                 270         


Ala Glu Pro Phe Trp Lys Glu Leu Ser His Leu Pro Ser Leu Tyr Asp 
        275                 280                 285             


Tyr Ser Ala Tyr Arg Arg Leu Ile Asp Gln Tyr Gly Thr His Tyr Leu 
    290                 295                 300                 


Gln Ser Gly Ser Leu Gly Gly Glu Tyr Arg Val Leu Phe Tyr Val Asp 
305                 310                 315                 320 


Ser Glu Lys Leu Lys Gln Asn Asp Phe Asn Ser Val Glu Glu Lys Lys 
                325                 330                 335     


Cys Lys Ser Ser Gly Trp His Phe Val Val Lys Phe Ser Ser His Gly 
            340                 345                 350         


Cys Lys Glu Leu Glu Asn Ala Leu Lys Ala Ala Ser Gly Thr Gln Asn 
        355                 360                 365             


Asn Val Leu Arg Gly Glu Pro Phe Ile Arg Gly Gly Gly Ala Gly Phe 
    370                 375                 380                 


Ile Ser Gly Leu Ser Tyr Leu Glu Leu Asp Asn Pro Ala Gly Asn Lys 
385                 390                 395                 400 


Arg Arg Tyr Ser Ala Trp Ala Glu Ser Val Thr Asn Leu Pro Gln Val 
                405                 410                 415     


Ile Lys Gln Lys Leu Thr Pro Leu Tyr Glu Leu Val Lys Glu Val Pro 
            420                 425                 430         


Cys Ala Ser Val Lys Lys Leu Tyr Leu Lys Trp Ala Leu Glu Glu Tyr 
        435                 440                 445             


Leu Asp Glu Phe Asp Pro Cys His Cys Arg Pro Cys Gln Asn Gly Gly 
    450                 455                 460                 


Leu Ala Thr Val Glu Gly Thr His Cys Leu Cys His Cys Lys Pro Tyr 
465                 470                 475                 480 


Thr Phe Gly Ala Ala Cys Glu Gln Gly Val Leu Val Gly Asn Gln Ala 
                485                 490                 495     


Gly Gly Val Asp Gly Gly Trp Ser Cys Trp Ser Ser Trp Ser Pro Cys 
            500                 505                 510         


Val Gln Gly Lys Lys Thr Arg Ser Arg Glu Cys Asn Asn Pro Pro Pro 
        515                 520                 525             


Ser Gly Gly Gly Arg Ser Cys Val Gly Glu Thr Thr Glu Ser Thr Gln 
    530                 535                 540                 


Cys Glu Asp Glu Glu Leu Glu His Leu Arg Leu Leu Glu Pro His Cys 
545                 550                 555                 560 


Phe Pro Leu Ser Leu Val Pro Thr Glu Phe Cys Pro Ser Pro Pro Ala 
                565                 570                 575     


Leu Lys Asp Gly Phe Val Gln Asp Glu Gly Thr Met Phe Pro Val Gly 
            580                 585                 590         


Lys Asn Val Val Tyr Thr Cys Asn Glu Gly Tyr Ser Leu Ile Gly Asn 
        595                 600                 605             


Pro Val Ala Arg Cys Gly Glu Asp Leu Arg Trp Leu Val Gly Glu Met 
    610                 615                 620                 


His Cys Gln Lys Ile Ala Cys Val Leu Pro Val Leu Met Asp Gly Ile 
625                 630                 635                 640 


Gln Ser His Pro Gln Lys Pro Phe Tyr Thr Val Gly Glu Lys Val Thr 
                645                 650                 655     


Val Ser Cys Ser Gly Gly Met Ser Leu Glu Gly Pro Ser Ala Phe Leu 
            660                 665                 670         


Cys Gly Ser Ser Leu Lys Trp Ser Pro Glu Met Lys Asn Ala Arg Cys 
        675                 680                 685             


Val Gln Lys Glu Asn Pro Leu Thr Gln Ala Val Pro Lys Cys Gln Arg 
    690                 695                 700                 


Trp Glu Lys Leu Gln Asn Ser Arg Cys Val Cys Lys Met Pro Tyr Glu 
705                 710                 715                 720 


Cys Gly Pro Ser Leu Asp Val Cys Ala Gln Asp Glu Arg Ser Lys Arg 
                725                 730                 735     


Ile Leu Pro Leu Thr Val Cys Lys Met His Val Leu His Cys Gln Gly 
            740                 745                 750         


Arg Asn Tyr Thr Leu Thr Gly Arg Asp Ser Cys Thr Leu Pro Ala Ser 
        755                 760                 765             


Ala Glu Lys Ala Cys Gly Ala Cys Pro Leu Trp Gly Lys Cys Asp Ala 
    770                 775                 780                 


Glu Ser Ser Lys Cys Val Cys Arg Glu Ala Ser Glu Cys Glu Glu Glu 
785                 790                 795                 800 


Gly Phe Ser Ile Cys Val Glu Val Asn Gly Lys Glu Gln Thr Met Ser 
                805                 810                 815     


Glu Cys Glu Ala Gly Ala Leu Arg Cys Arg Gly Gln Ser Ile Ser Val 
            820                 825                 830         


Thr Ser Ile Arg Pro Cys Ala Ala Glu Thr Gln 
        835                 840             


<210>  1924
<211>  324
<212>  PRT
<213>  Homo Sapiens

<400>  1924

Met Leu Trp Phe Arg Gly Ala Leu Gly Val Trp Val Trp Leu Ala Ala 
1               5                   10                  15      


Ala Ser Gln Pro Cys Lys Asn Ser Asn Ala Gly Arg Arg Gly Gln His 
            20                  25                  30          


Pro Arg Arg Pro Ala Gly Ser Cys Val Gln Arg Leu Thr Met Arg Asn 
        35                  40                  45              


Thr Ser Lys Glu Leu Gln Gly Ala Thr His Arg Tyr Ala Pro Cys Asp 
    50                  55                  60                  


Trp Tyr Tyr His Val Pro Val Lys Arg Ser Glu Lys Ala Val Asp Ala 
65                  70                  75                  80  


Pro Pro Ala Ser Gln Ile Pro Gly Leu Ser Asn Leu Gly Asp Ser His 
                85                  90                  95      


Ser Glu Asn Leu Pro Gly Thr Arg Arg Tyr Trp Ile Lys Glu Thr Asp 
            100                 105                 110         


Ser Glu Tyr Val Lys Leu Ala Lys Gln Gly Gly Arg Pro Asp Leu Leu 
        115                 120                 125             


Lys His Phe Ala Pro Gly Thr Arg Lys Gly Ser Pro Val Ala Tyr Ser 
    130                 135                 140                 


Leu Pro Asp Trp Tyr Ile His His Ser Lys Pro Pro Thr Ala Ser Gln 
145                 150                 155                 160 


Gln Glu Val Arg Ala Val Ser Met Pro Asp Tyr Met Val His Glu Glu 
                165                 170                 175     


Phe Asn Pro Asp Gln Ala Asn Gly Ser Tyr Ala Ser Arg Arg Gly Pro 
            180                 185                 190         


Phe Asp Phe Asp Met Lys Thr Val Trp Gln Arg Glu Ala Glu Glu Leu 
        195                 200                 205             


Glu Lys Glu Lys Lys Lys Leu Arg Leu Pro Ala Ile Asp Ser Lys Tyr 
    210                 215                 220                 


Leu Ser Lys Ala Gly Thr Pro Leu Gly Pro Lys Asn Pro Ala Gly Ser 
225                 230                 235                 240 


Arg Leu Ser Phe Pro Pro Val Asn Gly Tyr Lys Asp Glu Trp Leu Gln 
                245                 250                 255     


Gln Gln Gln Arg Ala Asp Ser Asp Lys Arg Thr Pro Lys Thr Ser Arg 
            260                 265                 270         


Ala Ser Val Leu Ser Gln Ser Pro Arg Asp Leu Glu Gly Pro Gln Asp 
        275                 280                 285             


Ala Ala Arg Leu Gln Asp Ala Glu Ala Ser Glu Gly Pro Glu Asp Thr 
    290                 295                 300                 


Pro Glu Ser Ser Gln Ser Pro Glu Glu Ser Val Ser Ala Ser Thr Pro 
305                 310                 315                 320 


Ala Glu Leu Lys 
                


<210>  1925
<211>  340
<212>  PRT
<213>  Homo Sapiens

<400>  1925

Met Leu Trp Phe Arg Gly Ala Leu Gly Val Trp Val Trp Leu Ala Ala 
1               5                   10                  15      


Ala Ser Gln Pro Cys Lys Asn Ser Asn Ala Gly Arg Arg Gly Gln His 
            20                  25                  30          


Pro Arg Arg Pro Ala Gly Ser Cys Val Gln Arg Leu Thr Met Arg Asn 
        35                  40                  45              


Thr Ser Lys Glu Leu Gln Gly Ala Thr His Arg Tyr Ala Pro Cys Asp 
    50                  55                  60                  


Trp Tyr Tyr His Val Pro Val Lys Arg Ser Glu Lys Ala Val Asp Ala 
65                  70                  75                  80  


Pro Pro Ala Ser Gln Ile Pro Gly Leu Ser Asn Leu Gly Asp Ser His 
                85                  90                  95      


Ser Glu Asn Leu Pro Gly Thr Arg Arg Tyr Trp Ile Lys Glu Thr Asp 
            100                 105                 110         


Ser Glu Tyr Val Lys Leu Ala Lys Gln Gly Gly Arg Pro Asp Leu Leu 
        115                 120                 125             


Lys His Phe Ala Pro Gly Thr Arg Lys Gly Ser Pro Val Ala Tyr Ser 
    130                 135                 140                 


Leu Pro Asp Trp Tyr Ile His His Ser Lys Pro Pro Thr Ala Ser Gln 
145                 150                 155                 160 


Gln Glu Val Arg Ala Val Ser Met Pro Asp Tyr Met Val His Glu Glu 
                165                 170                 175     


Phe Asn Pro Asp Gln Ala Asn Gly Ser Tyr Ala Ser Arg Arg Gly Pro 
            180                 185                 190         


Phe Asp Phe Asp Met Lys Thr Val Trp Gln Arg Glu Ala Glu Glu Leu 
        195                 200                 205             


Glu Lys Glu Lys Lys Lys Leu Arg Leu Pro Ala Ile Asp Ser Lys Tyr 
    210                 215                 220                 


Leu Ser Lys Ala Gly Thr Pro Leu Gly Pro Lys Asn Pro Ala Gly Ser 
225                 230                 235                 240 


Arg Leu Ser Phe Pro Pro Val Pro Gly Gln Lys Asn Ser Ser Pro Thr 
                245                 250                 255     


Asn Phe Ser Lys Leu Ile Ser Asn Gly Tyr Lys Asp Glu Trp Leu Gln 
            260                 265                 270         


Gln Gln Gln Arg Ala Asp Ser Asp Lys Arg Thr Pro Lys Thr Ser Arg 
        275                 280                 285             


Ala Ser Val Leu Ser Gln Ser Pro Arg Asp Leu Glu Gly Pro Gln Asp 
    290                 295                 300                 


Ala Ala Arg Leu Gln Asp Ala Glu Ala Ser Glu Gly Pro Glu Asp Thr 
305                 310                 315                 320 


Pro Glu Ser Ser Gln Ser Pro Glu Glu Ser Val Ser Ala Ser Thr Pro 
                325                 330                 335     


Ala Glu Leu Lys 
            340 


<210>  1926
<211>  157
<212>  PRT
<213>  Homo Sapiens

<400>  1926

Met Pro Asp Tyr Met Val His Glu Glu Phe Asn Pro Asp Gln Ala Asn 
1               5                   10                  15      


Gly Ser Tyr Ala Ser Arg Arg Gly Pro Phe Asp Phe Asp Met Lys Thr 
            20                  25                  30          


Val Trp Gln Arg Glu Ala Glu Glu Leu Glu Lys Glu Lys Lys Lys Leu 
        35                  40                  45              


Arg Leu Pro Ala Ile Asp Ser Lys Tyr Leu Ser Lys Ala Gly Thr Pro 
    50                  55                  60                  


Leu Gly Pro Lys Asn Pro Ala Gly Ser Arg Leu Ser Phe Pro Pro Val 
65                  70                  75                  80  


Asn Gly Tyr Lys Asp Glu Trp Leu Gln Gln Gln Gln Arg Ala Asp Ser 
                85                  90                  95      


Asp Lys Arg Thr Pro Lys Thr Ser Arg Ala Ser Val Leu Ser Gln Ser 
            100                 105                 110         


Pro Arg Asp Leu Glu Gly Pro Gln Asp Ala Ala Arg Leu Gln Asp Ala 
        115                 120                 125             


Glu Ala Ser Glu Gly Pro Glu Asp Thr Pro Glu Ser Ser Gln Ser Pro 
    130                 135                 140                 


Glu Glu Ser Val Ser Ala Ser Thr Pro Ala Glu Leu Lys 
145                 150                 155         


<210>  1927
<211>  153
<212>  PRT
<213>  Homo Sapiens

<400>  1927

Met Pro Asp Tyr Met Val His Glu Glu Phe Asn Pro Asp Gln Ala Asn 
1               5                   10                  15      


Gly Ser Tyr Ala Ser Arg Arg Gly Pro Phe Asp Phe Asp Met Lys Thr 
            20                  25                  30          


Val Trp Gln Arg Glu Ala Glu Glu Leu Glu Lys Glu Lys Lys Lys Leu 
        35                  40                  45              


Arg Leu Pro Ala Ile Asp Ser Lys Tyr Leu Ser Lys Ala Gly Thr Pro 
    50                  55                  60                  


Leu Gly Pro Lys Asn Pro Ala Gly Ser Arg Leu Ser Phe Pro Pro Val 
65                  70                  75                  80  


Asn Gly Tyr Lys Asp Glu Trp Leu Gln Gln Gln Gln Arg Ala Asp Ser 
                85                  90                  95      


Asp Lys Arg Thr Pro Lys Thr Ser Arg Ala Ser Val Leu Ser Gln Ser 
            100                 105                 110         


Pro Arg Asp Leu Glu Gly Pro Gln Asp Ala Ala Arg Leu Gln Asp Ala 
        115                 120                 125             


Glu Ala Ser Glu Gly Pro Glu Asp Thr Pro Gly Pro Glu Glu Ser Val 
    130                 135                 140                 


Ser Ala Ser Thr Pro Ala Glu Leu Lys 
145                 150             


<210>  1928
<211>  295
<212>  PRT
<213>  Homo Sapiens

<400>  1928

Met Arg Asn Thr Ser Lys Glu Leu Gln Gly Ala Thr His Arg Tyr Ala 
1               5                   10                  15      


Pro Cys Asp Trp Tyr Tyr His Val Pro Val Lys Arg Ser Glu Lys Ala 
            20                  25                  30          


Val Asp Ala Pro Pro Ala Ser Gln Ile Pro Gly Leu Ser Asn Leu Gly 
        35                  40                  45              


Asp Ser His Ser Glu Asn Leu Pro Gly Thr Arg Arg Tyr Trp Ile Lys 
    50                  55                  60                  


Glu Thr Asp Ser Glu Tyr Val Lys Leu Ala Lys Gln Gly Gly Arg Pro 
65                  70                  75                  80  


Asp Leu Leu Lys His Phe Ala Pro Gly Thr Arg Lys Gly Ser Pro Val 
                85                  90                  95      


Ala Tyr Ser Leu Pro Asp Trp Tyr Ile His His Ser Lys Pro Pro Thr 
            100                 105                 110         


Ala Ser Gln Gln Glu Val Arg Ala Val Ser Met Pro Asp Tyr Met Val 
        115                 120                 125             


His Glu Glu Phe Asn Pro Asp Gln Ala Asn Gly Ser Tyr Ala Ser Arg 
    130                 135                 140                 


Arg Gly Pro Phe Asp Phe Asp Met Lys Thr Val Trp Gln Arg Glu Ala 
145                 150                 155                 160 


Glu Glu Leu Glu Lys Glu Lys Lys Lys Leu Arg Leu Pro Ala Ile Asp 
                165                 170                 175     


Ser Lys Tyr Leu Ser Lys Ala Gly Thr Pro Leu Gly Pro Lys Asn Pro 
            180                 185                 190         


Ala Gly Ser Arg Leu Ser Phe Pro Pro Val Pro Gly Gln Lys Asn Ser 
        195                 200                 205             


Ser Pro Thr Asn Phe Ser Lys Leu Ile Ser Asn Gly Tyr Lys Asp Glu 
    210                 215                 220                 


Trp Leu Gln Gln Gln Gln Arg Ala Asp Ser Asp Lys Arg Thr Pro Lys 
225                 230                 235                 240 


Thr Ser Arg Ala Ser Val Leu Ser Gln Ser Pro Arg Asp Leu Glu Gly 
                245                 250                 255     


Pro Gln Asp Ala Ala Arg Leu Gln Asp Ala Glu Ala Ser Glu Gly Pro 
            260                 265                 270         


Glu Asp Thr Pro Glu Ser Ser Gln Ser Pro Glu Glu Ser Val Ser Ala 
        275                 280                 285             


Ser Thr Pro Ala Glu Leu Lys 
    290                 295 


<210>  1929
<211>  584
<212>  PRT
<213>  Homo Sapiens

<400>  1929

Met Phe Ala Val Val Phe Phe Ile Leu Ser Leu Met Thr Cys Gln Pro 
1               5                   10                  15      


Gly Val Thr Ala Gln Glu Lys Val Asn Gln Arg Val Arg Arg Ala Ala 
            20                  25                  30          


Thr Pro Ala Ala Val Thr Cys Gln Leu Ser Asn Trp Ser Glu Trp Thr 
        35                  40                  45              


Asp Cys Phe Pro Cys Gln Asp Lys Lys Tyr Arg His Arg Ser Leu Leu 
    50                  55                  60                  


Gln Pro Asn Lys Phe Gly Gly Thr Ile Cys Ser Gly Asp Ile Trp Asp 
65                  70                  75                  80  


Gln Ala Ser Cys Ser Ser Ser Thr Thr Cys Val Arg Gln Ala Gln Cys 
                85                  90                  95      


Gly Gln Asp Phe Gln Cys Lys Glu Thr Gly Arg Cys Leu Lys Arg His 
            100                 105                 110         


Leu Val Cys Asn Gly Asp Gln Asp Cys Leu Asp Gly Ser Asp Glu Asp 
        115                 120                 125             


Asp Cys Glu Asp Val Arg Ala Ile Asp Glu Asp Cys Ser Gln Tyr Glu 
    130                 135                 140                 


Pro Ile Pro Gly Ser Gln Lys Ala Ala Leu Gly Tyr Asn Ile Leu Thr 
145                 150                 155                 160 


Gln Glu Asp Ala Gln Ser Val Tyr Asp Ala Ser Tyr Tyr Gly Gly Gln 
                165                 170                 175     


Cys Glu Thr Val Tyr Asn Gly Glu Trp Arg Glu Leu Arg Tyr Asp Ser 
            180                 185                 190         


Thr Cys Glu Arg Leu Tyr Tyr Gly Asp Asp Glu Lys Tyr Phe Arg Lys 
        195                 200                 205             


Pro Tyr Asn Phe Leu Lys Tyr His Phe Glu Ala Leu Ala Asp Thr Gly 
    210                 215                 220                 


Ile Ser Ser Glu Phe Tyr Asp Asn Ala Asn Asp Leu Leu Ser Lys Val 
225                 230                 235                 240 


Lys Lys Asp Lys Ser Asp Ser Phe Gly Val Thr Ile Gly Ile Gly Pro 
                245                 250                 255     


Ala Gly Ser Pro Leu Leu Val Gly Val Gly Val Ser His Ser Gln Asp 
            260                 265                 270         


Thr Ser Phe Leu Asn Glu Leu Asn Lys Tyr Asn Glu Lys Lys Phe Ile 
        275                 280                 285             


Phe Thr Arg Ile Phe Thr Lys Val Gln Thr Ala His Phe Lys Met Arg 
    290                 295                 300                 


Lys Asp Asp Ile Met Leu Asp Glu Gly Met Leu Gln Ser Leu Met Glu 
305                 310                 315                 320 


Leu Pro Asp Gln Tyr Asn Tyr Gly Met Tyr Ala Lys Phe Ile Asn Asp 
                325                 330                 335     


Tyr Gly Thr His Tyr Ile Thr Ser Gly Ser Met Gly Gly Ile Tyr Glu 
            340                 345                 350         


Tyr Ile Leu Val Ile Asp Lys Ala Lys Met Glu Ser Leu Gly Ile Thr 
        355                 360                 365             


Ser Arg Asp Ile Thr Thr Cys Phe Gly Gly Ser Leu Gly Ile Gln Tyr 
    370                 375                 380                 


Glu Asp Lys Ile Asn Val Gly Gly Gly Leu Ser Gly Asp His Cys Lys 
385                 390                 395                 400 


Lys Phe Gly Gly Gly Lys Thr Glu Arg Ala Arg Lys Ala Met Ala Val 
                405                 410                 415     


Glu Asp Ile Ile Ser Arg Val Arg Gly Gly Ser Ser Gly Trp Ser Gly 
            420                 425                 430         


Gly Leu Ala Gln Asn Arg Ser Thr Ile Thr Tyr Arg Ser Trp Gly Arg 
        435                 440                 445             


Ser Leu Lys Tyr Asn Pro Val Val Ile Asp Phe Glu Met Gln Pro Ile 
    450                 455                 460                 


His Glu Val Leu Arg His Thr Ser Leu Gly Pro Leu Glu Ala Lys Arg 
465                 470                 475                 480 


Gln Asn Leu Arg Arg Ala Leu Asp Gln Tyr Leu Met Glu Phe Asn Ala 
                485                 490                 495     


Cys Arg Cys Gly Pro Cys Phe Asn Asn Gly Val Pro Ile Leu Glu Gly 
            500                 505                 510         


Thr Ser Cys Arg Cys Gln Cys Arg Leu Gly Ser Leu Gly Ala Ala Cys 
        515                 520                 525             


Glu Gln Thr Gln Thr Glu Gly Ala Lys Ala Asp Gly Ser Trp Ser Cys 
    530                 535                 540                 


Trp Ser Ser Trp Ser Val Cys Arg Ala Gly Ile Gln Glu Arg Arg Arg 
545                 550                 555                 560 


Glu Cys Asp Asn Pro Ala Pro Gln Asn Gly Gly Ala Ser Cys Pro Gly 
                565                 570                 575     


Arg Lys Val Gln Thr Gln Ala Cys 
            580                 


<210>  1930
<211>  529
<212>  PRT
<213>  Homo Sapiens

<400>  1930

Met Asp Thr Cys Met Thr Leu Ala Phe Thr Leu Ser Gly Arg Phe Phe 
1               5                   10                  15      


Met Leu Leu Ser Gln Tyr Arg Tyr Ala Tyr Leu Leu Gln Pro Ser Gln 
            20                  25                  30          


Phe His Gly Glu Pro Cys Asn Phe Ser Asp Lys Glu Val Glu Asp Cys 
        35                  40                  45              


Val Thr Asn Arg Pro Cys Gly Ser Gln Val Arg Cys Glu Gly Phe Val 
    50                  55                  60                  


Cys Ala Gln Thr Gly Arg Cys Val Asn Arg Arg Leu Leu Cys Asn Gly 
65                  70                  75                  80  


Asp Asn Asp Cys Gly Asp Gln Ser Asp Glu Ala Asn Cys Arg Arg Ile 
                85                  90                  95      


Tyr Lys Lys Cys Gln His Glu Met Asp Gln Tyr Trp Gly Ile Gly Ser 
            100                 105                 110         


Leu Ala Ser Gly Ile Asn Leu Phe Thr Asn Ser Phe Glu Gly Pro Val 
        115                 120                 125             


Leu Asp His Arg Tyr Tyr Ala Gly Gly Cys Ser Pro His Tyr Ile Leu 
    130                 135                 140                 


Asn Thr Arg Phe Arg Lys Pro Tyr Asn Val Glu Ser Tyr Thr Pro Gln 
145                 150                 155                 160 


Thr Gln Gly Lys Tyr Glu Phe Ile Leu Lys Glu Tyr Glu Ser Tyr Ser 
                165                 170                 175     


Asp Phe Glu Arg Asn Val Thr Glu Lys Met Ala Ser Lys Ser Gly Phe 
            180                 185                 190         


Ser Phe Gly Phe Lys Ile Pro Gly Ile Phe Glu Leu Gly Ile Ser Ser 
        195                 200                 205             


Gln Ser Asp Arg Gly Lys His Tyr Ile Arg Arg Thr Lys Arg Phe Ser 
    210                 215                 220                 


His Thr Lys Ser Val Phe Leu His Ala Arg Ser Asp Leu Glu Val Ala 
225                 230                 235                 240 


His Tyr Lys Leu Lys Pro Arg Ser Leu Met Leu His Tyr Glu Phe Leu 
                245                 250                 255     


Gln Arg Val Lys Arg Leu Pro Leu Glu Tyr Ser Tyr Gly Glu Tyr Arg 
            260                 265                 270         


Asp Leu Phe Arg Asp Phe Gly Thr His Tyr Ile Thr Glu Ala Val Leu 
        275                 280                 285             


Gly Gly Ile Tyr Glu Tyr Thr Leu Val Met Asn Lys Glu Ala Met Glu 
    290                 295                 300                 


Arg Gly Asp Tyr Thr Leu Asn Asn Val His Ala Cys Ala Lys Asn Asp 
305                 310                 315                 320 


Phe Lys Ile Gly Gly Ala Ile Glu Glu Val Tyr Val Ser Leu Gly Val 
                325                 330                 335     


Ser Val Gly Lys Cys Arg Gly Ile Leu Asn Glu Ile Lys Asp Arg Asn 
            340                 345                 350         


Lys Arg Asp Thr Met Val Glu Asp Leu Val Val Leu Val Arg Gly Gly 
        355                 360                 365             


Ala Ser Glu His Ile Thr Thr Leu Ala Tyr Gln Glu Leu Pro Thr Ala 
    370                 375                 380                 


Asp Leu Met Gln Glu Trp Gly Asp Ala Val Gln Tyr Asn Pro Ala Ile 
385                 390                 395                 400 


Ile Lys Val Lys Val Glu Pro Leu Tyr Glu Leu Val Thr Ala Thr Asp 
                405                 410                 415     


Phe Ala Tyr Ser Ser Thr Val Arg Gln Asn Met Lys Gln Ala Leu Glu 
            420                 425                 430         


Glu Phe Gln Lys Glu Val Ser Ser Cys His Cys Ala Pro Cys Gln Gly 
        435                 440                 445             


Asn Gly Val Pro Val Leu Lys Gly Ser Arg Cys Asp Cys Ile Cys Pro 
    450                 455                 460                 


Val Gly Ser Gln Gly Leu Ala Cys Glu Val Ser Tyr Arg Lys Asn Thr 
465                 470                 475                 480 


Pro Ile Asp Gly Lys Trp Asn Cys Trp Ser Asn Trp Ser Ser Cys Ser 
                485                 490                 495     


Gly Arg Arg Lys Thr Arg Gln Arg Gln Cys Asn Asn Pro Pro Pro Gln 
            500                 505                 510         


Asn Gly Gly Ser Pro Cys Ser Gly Pro Ala Ser Glu Thr Leu Asp Cys 
        515                 520                 525             


Ser 
    


<210>  1931
<211>  591
<212>  PRT
<213>  Homo Sapiens

<400>  1931

Met Lys Asn Ser Arg Thr Trp Ala Trp Arg Ala Pro Val Glu Leu Phe 
1               5                   10                  15      


Leu Leu Cys Ala Ala Leu Gly Cys Leu Ser Leu Pro Gly Ser Arg Gly 
            20                  25                  30          


Glu Arg Pro His Ser Phe Gly Ser Asn Ala Val Asn Lys Ser Phe Ala 
        35                  40                  45              


Lys Ser Arg Gln Met Arg Ser Val Asp Val Thr Leu Met Pro Ile Asp 
    50                  55                  60                  


Cys Glu Leu Ser Ser Trp Ser Ser Trp Thr Thr Cys Asp Pro Cys Gln 
65                  70                  75                  80  


Lys Lys Arg Tyr Arg Tyr Ala Tyr Leu Leu Gln Pro Ser Gln Phe His 
                85                  90                  95      


Gly Glu Pro Cys Asn Phe Ser Asp Lys Glu Val Glu Asp Cys Val Thr 
            100                 105                 110         


Asn Arg Pro Cys Gly Ser Gln Val Arg Cys Glu Gly Phe Val Cys Ala 
        115                 120                 125             


Gln Thr Gly Arg Cys Val Asn Arg Arg Leu Leu Cys Asn Gly Asp Asn 
    130                 135                 140                 


Asp Cys Gly Asp Gln Ser Asp Glu Ala Asn Cys Arg Arg Ile Tyr Lys 
145                 150                 155                 160 


Lys Cys Gln His Glu Met Asp Gln Tyr Trp Gly Ile Gly Ser Leu Ala 
                165                 170                 175     


Ser Gly Ile Asn Leu Phe Thr Asn Ser Phe Glu Gly Pro Val Leu Asp 
            180                 185                 190         


His Arg Tyr Tyr Ala Gly Gly Cys Ser Pro His Tyr Ile Leu Asn Thr 
        195                 200                 205             


Arg Phe Arg Lys Pro Tyr Asn Val Glu Ser Tyr Thr Pro Gln Thr Gln 
    210                 215                 220                 


Gly Lys Tyr Glu Phe Ile Leu Lys Glu Tyr Glu Ser Tyr Ser Asp Phe 
225                 230                 235                 240 


Glu Arg Asn Val Thr Glu Lys Met Ala Ser Lys Ser Gly Phe Ser Phe 
                245                 250                 255     


Gly Phe Lys Ile Pro Gly Ile Phe Glu Leu Gly Ile Ser Ser Gln Ser 
            260                 265                 270         


Asp Arg Gly Lys His Tyr Ile Arg Arg Thr Lys Arg Phe Ser His Thr 
        275                 280                 285             


Lys Ser Val Phe Leu His Ala Arg Ser Asp Leu Glu Val Ala His Tyr 
    290                 295                 300                 


Lys Leu Lys Pro Arg Ser Leu Met Leu His Tyr Glu Phe Leu Gln Arg 
305                 310                 315                 320 


Val Lys Arg Leu Pro Leu Glu Tyr Ser Tyr Gly Glu Tyr Arg Asp Leu 
                325                 330                 335     


Phe Arg Asp Phe Gly Thr His Tyr Ile Thr Glu Ala Val Leu Gly Gly 
            340                 345                 350         


Ile Tyr Glu Tyr Thr Leu Val Met Asn Lys Glu Ala Met Glu Arg Gly 
        355                 360                 365             


Asp Tyr Thr Leu Asn Asn Val His Ala Cys Ala Lys Asn Asp Phe Lys 
    370                 375                 380                 


Ile Gly Gly Ala Ile Glu Glu Val Tyr Val Ser Leu Gly Val Ser Val 
385                 390                 395                 400 


Gly Lys Cys Arg Gly Ile Leu Asn Glu Ile Lys Asp Arg Asn Lys Arg 
                405                 410                 415     


Asp Thr Met Val Glu Asp Leu Val Val Leu Val Arg Gly Gly Ala Ser 
            420                 425                 430         


Glu His Ile Thr Thr Leu Ala Tyr Gln Glu Leu Pro Thr Ala Asp Leu 
        435                 440                 445             


Met Gln Glu Trp Gly Asp Ala Val Gln Tyr Asn Pro Ala Ile Ile Lys 
    450                 455                 460                 


Val Lys Val Glu Pro Leu Tyr Glu Leu Val Thr Ala Thr Asp Phe Ala 
465                 470                 475                 480 


Tyr Ser Ser Thr Val Arg Gln Asn Met Lys Gln Ala Leu Glu Glu Phe 
                485                 490                 495     


Gln Lys Glu Val Ser Ser Cys His Cys Ala Pro Cys Gln Gly Asn Gly 
            500                 505                 510         


Val Pro Val Leu Lys Gly Ser Arg Cys Asp Cys Ile Cys Pro Val Gly 
        515                 520                 525             


Ser Gln Gly Leu Ala Cys Glu Val Ser Tyr Arg Lys Asn Thr Pro Ile 
    530                 535                 540                 


Asp Gly Lys Trp Asn Cys Trp Ser Asn Trp Ser Ser Cys Ser Gly Arg 
545                 550                 555                 560 


Arg Lys Thr Arg Gln Arg Gln Cys Asn Asn Pro Pro Pro Gln Asn Gly 
                565                 570                 575     


Gly Ser Pro Cys Ser Gly Pro Ala Ser Glu Thr Leu Asp Cys Ser 
            580                 585                 590     


<210>  1932
<211>  539
<212>  PRT
<213>  Homo Sapiens

<400>  1932

Met Arg Ser Val Asp Val Thr Leu Met Pro Ile Asp Cys Glu Leu Ser 
1               5                   10                  15      


Ser Trp Ser Ser Trp Thr Thr Cys Asp Pro Cys Gln Lys Lys Arg Tyr 
            20                  25                  30          


Arg Tyr Ala Tyr Leu Leu Gln Pro Ser Gln Phe His Gly Glu Pro Cys 
        35                  40                  45              


Asn Phe Ser Asp Lys Glu Val Glu Asp Cys Val Thr Asn Arg Pro Cys 
    50                  55                  60                  


Gly Ser Gln Val Arg Cys Glu Gly Phe Val Cys Ala Gln Thr Gly Arg 
65                  70                  75                  80  


Cys Val Asn Arg Arg Leu Leu Cys Asn Gly Asp Asn Asp Cys Gly Asp 
                85                  90                  95      


Gln Ser Asp Glu Ala Asn Cys Arg Arg Ile Tyr Lys Lys Cys Gln His 
            100                 105                 110         


Glu Met Asp Gln Tyr Trp Gly Ile Gly Ser Leu Ala Ser Gly Ile Asn 
        115                 120                 125             


Leu Phe Thr Asn Ser Phe Glu Gly Pro Val Leu Asp His Arg Tyr Tyr 
    130                 135                 140                 


Ala Gly Gly Cys Ser Pro His Tyr Ile Leu Asn Thr Arg Phe Arg Lys 
145                 150                 155                 160 


Pro Tyr Asn Val Glu Ser Tyr Thr Pro Gln Thr Gln Gly Lys Tyr Glu 
                165                 170                 175     


Phe Ile Leu Lys Glu Tyr Glu Ser Tyr Ser Asp Phe Glu Arg Asn Val 
            180                 185                 190         


Thr Glu Lys Met Ala Ser Lys Ser Gly Phe Ser Phe Gly Phe Lys Ile 
        195                 200                 205             


Pro Gly Ile Phe Glu Leu Gly Ile Ser Ser Gln Ser Asp Arg Gly Lys 
    210                 215                 220                 


His Tyr Ile Arg Arg Thr Lys Arg Phe Ser His Thr Lys Ser Val Phe 
225                 230                 235                 240 


Leu His Ala Arg Ser Asp Leu Glu Val Ala His Tyr Lys Leu Lys Pro 
                245                 250                 255     


Arg Ser Leu Met Leu His Tyr Glu Phe Leu Gln Arg Val Lys Arg Leu 
            260                 265                 270         


Pro Leu Glu Tyr Ser Tyr Gly Glu Tyr Arg Asp Leu Phe Arg Asp Phe 
        275                 280                 285             


Gly Thr His Tyr Ile Thr Glu Ala Val Leu Gly Gly Ile Tyr Glu Tyr 
    290                 295                 300                 


Thr Leu Val Met Asn Lys Glu Ala Met Glu Arg Gly Asp Tyr Thr Leu 
305                 310                 315                 320 


Asn Asn Val His Ala Cys Ala Lys Asn Asp Phe Lys Ile Gly Gly Ala 
                325                 330                 335     


Ile Glu Glu Val Tyr Val Ser Leu Gly Val Ser Val Gly Lys Cys Arg 
            340                 345                 350         


Gly Ile Leu Asn Glu Ile Lys Asp Arg Asn Lys Arg Asp Thr Met Val 
        355                 360                 365             


Glu Asp Leu Val Val Leu Val Arg Gly Gly Ala Ser Glu His Ile Thr 
    370                 375                 380                 


Thr Leu Ala Tyr Gln Glu Leu Pro Thr Ala Asp Leu Met Gln Glu Trp 
385                 390                 395                 400 


Gly Asp Ala Val Gln Tyr Asn Pro Ala Ile Ile Lys Val Lys Val Glu 
                405                 410                 415     


Pro Leu Tyr Glu Leu Val Thr Ala Thr Asp Phe Ala Tyr Ser Ser Thr 
            420                 425                 430         


Val Arg Gln Asn Met Lys Gln Ala Leu Glu Glu Phe Gln Lys Glu Val 
        435                 440                 445             


Ser Ser Cys His Cys Ala Pro Cys Gln Gly Asn Gly Val Pro Val Leu 
    450                 455                 460                 


Lys Gly Ser Arg Cys Asp Cys Ile Cys Pro Val Gly Ser Gln Gly Leu 
465                 470                 475                 480 


Ala Cys Glu Val Ser Tyr Arg Lys Asn Thr Pro Ile Asp Gly Lys Trp 
                485                 490                 495     


Asn Cys Trp Ser Asn Trp Ser Ser Cys Ser Gly Arg Arg Lys Thr Arg 
            500                 505                 510         


Gln Arg Gln Cys Asn Asn Pro Pro Pro Gln Asn Gly Gly Ser Pro Cys 
        515                 520                 525             


Ser Gly Pro Ala Ser Glu Thr Leu Asp Cys Ser 
    530                 535                 


<210>  1933
<211>  202
<212>  PRT
<213>  Homo Sapiens

<400>  1933

Met Leu Pro Pro Gly Thr Ala Thr Leu Leu Thr Leu Leu Leu Ala Ala 
1               5                   10                  15      


Gly Ser Leu Gly Gln Lys Pro Gln Arg Pro Arg Arg Pro Ala Ser Pro 
            20                  25                  30          


Ile Ser Thr Ile Gln Pro Lys Ala Asn Phe Asp Ala Gln Gln Phe Ala 
        35                  40                  45              


Gly Thr Trp Leu Leu Val Ala Val Gly Ser Ala Cys Arg Phe Leu Gln 
    50                  55                  60                  


Glu Gln Gly His Arg Ala Glu Ala Thr Thr Leu His Val Ala Pro Gln 
65                  70                  75                  80  


Gly Thr Ala Met Ala Val Ser Thr Phe Arg Lys Leu Asp Gly Ile Cys 
                85                  90                  95      


Trp Gln Val Arg Gln Leu Tyr Gly Asp Thr Gly Val Leu Gly Arg Phe 
            100                 105                 110         


Leu Leu Gln Ala Arg Asp Ala Arg Gly Ala Val His Val Val Val Ala 
        115                 120                 125             


Glu Thr Asp Tyr Gln Ser Phe Ala Val Leu Tyr Leu Glu Arg Ala Gly 
    130                 135                 140                 


Gln Leu Ser Val Lys Leu Tyr Ala Arg Ser Leu Pro Val Ser Asp Ser 
145                 150                 155                 160 


Val Leu Ser Gly Phe Glu Gln Arg Val Gln Glu Ala His Leu Thr Glu 
                165                 170                 175     


Asp Gln Ile Phe Tyr Phe Pro Lys Tyr Gly Phe Cys Glu Ala Ala Asp 
            180                 185                 190         


Gln Phe His Val Leu Asp Glu Val Arg Arg 
        195                 200         


<210>  1934
<211>  164
<212>  PRT
<213>  Homo Sapiens

<400>  1934

Met Leu Pro Pro Gly Thr Ala Thr Leu Leu Thr Leu Leu Leu Ala Ala 
1               5                   10                  15      


Gly Ser Leu Gly Gln Lys Pro Gln Arg Pro Arg Arg Pro Ala Ser Pro 
            20                  25                  30          


Ile Ser Thr Ile Gln Pro Lys Ala Asn Phe Asp Ala Gln Gln Phe Ala 
        35                  40                  45              


Gly Thr Trp Leu Leu Val Ala Val Gly Ser Ala Cys Arg Phe Leu Gln 
    50                  55                  60                  


Glu Gln Gly His Arg Ala Glu Ala Thr Thr Leu His Val Ala Pro Gln 
65                  70                  75                  80  


Gly Thr Ala Met Ala Val Ser Thr Phe Arg Lys Leu Asp Gly Ile Cys 
                85                  90                  95      


Trp Gln Val Arg Gln Leu Tyr Gly Asp Thr Gly Val Leu Gly Arg Phe 
            100                 105                 110         


Leu Leu Gln Ala Arg Asp Ala Arg Gly Ala Val His Val Val Val Ala 
        115                 120                 125             


Glu Thr Asp Tyr Gln Ser Phe Ala Val Leu Tyr Leu Glu Arg Ala Gly 
    130                 135                 140                 


Gln Leu Ser Val Lys Leu Tyr Gly Ala Gln Gly Val Val Thr Asp Arg 
145                 150                 155                 160 


Pro Gly Val Gly 
                


<210>  1935
<211>  559
<212>  PRT
<213>  Homo Sapiens

<400>  1935

Met Ser Ala Cys Arg Ser Phe Ala Val Ala Ile Cys Ile Leu Glu Ile 
1               5                   10                  15      


Ser Ile Leu Thr Ala Gln Tyr Thr Thr Ser Tyr Asp Pro Glu Leu Thr 
            20                  25                  30          


Glu Ser Ser Gly Ser Ala Ser His Ile Asp Cys Arg Met Ser Pro Trp 
        35                  40                  45              


Ser Glu Trp Ser Gln Cys Asp Pro Cys Leu Arg Gln Met Phe Arg Ser 
    50                  55                  60                  


Arg Ser Ile Glu Val Phe Gly Gln Phe Asn Gly Lys Arg Cys Thr Asp 
65                  70                  75                  80  


Ala Val Gly Asp Arg Arg Gln Cys Val Pro Thr Glu Pro Cys Glu Asp 
                85                  90                  95      


Ala Glu Asp Asp Cys Gly Asn Asp Phe Gln Cys Ser Thr Gly Arg Cys 
            100                 105                 110         


Ile Lys Met Arg Leu Arg Cys Asn Gly Asp Asn Asp Cys Gly Asp Phe 
        115                 120                 125             


Ser Asp Glu Asp Asp Cys Glu Ser Glu Pro Arg Pro Pro Cys Arg Asp 
    130                 135                 140                 


Arg Val Val Glu Glu Ser Glu Leu Ala Arg Thr Ala Gly Tyr Gly Ile 
145                 150                 155                 160 


Asn Ile Leu Gly Met Asp Pro Leu Ser Thr Pro Phe Asp Asn Glu Phe 
                165                 170                 175     


Tyr Asn Gly Leu Cys Asn Arg Asp Arg Asp Gly Asn Thr Leu Thr Tyr 
            180                 185                 190         


Tyr Arg Arg Pro Trp Asn Val Ala Ser Leu Ile Tyr Glu Thr Lys Gly 
        195                 200                 205             


Glu Lys Asn Phe Arg Thr Glu His Tyr Glu Glu Gln Ile Glu Ala Phe 
    210                 215                 220                 


Lys Ser Ile Ile Gln Glu Lys Thr Ser Asn Phe Asn Ala Ala Ile Ser 
225                 230                 235                 240 


Leu Lys Phe Thr Pro Thr Glu Thr Asn Lys Ala Glu Gln Cys Cys Glu 
                245                 250                 255     


Glu Thr Ala Ser Ser Ile Ser Leu His Gly Lys Gly Ser Phe Arg Phe 
            260                 265                 270         


Ser Tyr Ser Lys Asn Glu Thr Tyr Gln Leu Phe Leu Ser Tyr Ser Ser 
        275                 280                 285             


Lys Lys Glu Lys Met Phe Leu His Val Lys Gly Glu Ile His Leu Gly 
    290                 295                 300                 


Arg Phe Val Met Arg Asn Arg Asp Val Val Leu Thr Thr Thr Phe Val 
305                 310                 315                 320 


Asp Asp Ile Lys Ala Leu Pro Thr Thr Tyr Glu Lys Gly Glu Tyr Phe 
                325                 330                 335     


Ala Phe Leu Glu Thr Tyr Gly Thr His Tyr Ser Ser Ser Gly Ser Leu 
            340                 345                 350         


Gly Gly Leu Tyr Glu Leu Ile Tyr Val Leu Asp Lys Ala Ser Met Lys 
        355                 360                 365             


Arg Lys Gly Val Glu Leu Lys Asp Ile Lys Arg Cys Leu Gly Tyr His 
    370                 375                 380                 


Leu Asp Val Ser Leu Ala Phe Ser Glu Ile Ser Val Gly Ala Glu Phe 
385                 390                 395                 400 


Asn Lys Asp Asp Cys Val Lys Arg Gly Glu Gly Arg Ala Val Asn Ile 
                405                 410                 415     


Thr Ser Glu Asn Leu Ile Asp Asp Val Val Ser Leu Ile Arg Gly Gly 
            420                 425                 430         


Thr Arg Lys Tyr Ala Phe Glu Leu Lys Glu Lys Leu Leu Arg Gly Thr 
        435                 440                 445             


Val Ile Asp Val Thr Asp Phe Val Asn Trp Ala Ser Ser Ile Asn Asp 
    450                 455                 460                 


Ala Pro Val Leu Ile Ser Gln Lys Leu Ser Pro Ile Tyr Asn Leu Val 
465                 470                 475                 480 


Pro Val Lys Met Lys Asn Ala His Leu Lys Lys Gln Asn Leu Glu Arg 
                485                 490                 495     


Ala Ile Glu Asp Tyr Ile Asn Glu Phe Ser Val Arg Lys Cys His Thr 
            500                 505                 510         


Cys Gln Asn Gly Gly Thr Val Ile Leu Met Asp Gly Lys Cys Leu Cys 
        515                 520                 525             


Ala Cys Pro Phe Lys Phe Glu Gly Ile Ala Cys Glu Ile Ser Lys Gln 
    530                 535                 540                 


Lys Ile Ser Glu Gly Leu Pro Ala Leu Glu Phe Pro Asn Glu Lys 
545                 550                 555                 


<210>  1936
<211>  183
<212>  PRT
<213>  Homo Sapiens

<400>  1936

Met Val Arg Ile Trp Thr Thr Ile Met Ile Val Leu Ile Leu Leu Leu 
1               5                   10                  15      


Arg Ile Gly Pro Asn Lys Pro Ser Leu Ser Gly Arg Gln Ala Pro Ala 
            20                  25                  30          


Gln Ala Gln Thr Ser Asp Leu Val Pro Ser Leu Phe Pro Leu Gly Leu 
        35                  40                  45              


Trp Ala Pro Gly Phe Cys Thr Trp Ser Ser Pro Asp Glu Asp Lys Arg 
    50                  55                  60                  


Pro Arg Lys Pro Val Pro Gly Thr Gly Asn Arg Asp Ser Gly Thr Arg 
65                  70                  75                  80  


Arg Arg Leu Gln Asp Ala Thr Glu Gln Asp Pro Arg Pro Gly Asn Asp 
                85                  90                  95      


Val Ala Ser Ala Glu Thr Ala Gly Pro Pro Ser Pro Ser Gly Ile Arg 
            100                 105                 110         


Ala Gln Asp Arg Ala Pro Arg His Arg Arg Ala Pro Pro Ala Arg Met 
        115                 120                 125             


Pro Val Ala Pro Ala Pro Ser Ala Asp Gly Glu Pro Leu Gln Glu Gln 
    130                 135                 140                 


Gly Gly Gly Leu Phe His Arg Thr Arg Ser Val Tyr Asn Gly Leu Glu 
145                 150                 155                 160 


Leu Asn Thr Trp Met Lys Val Glu Arg Leu Phe Val Glu Lys Phe His 
                165                 170                 175     


Gln Ser Phe Ser Leu Asp Asn 
            180             


<210>  1937
<211>  235
<212>  PRT
<213>  Homo Sapiens

<400>  1937

Met Val Arg Ile Trp Thr Thr Ile Met Ile Val Leu Ile Leu Leu Leu 
1               5                   10                  15      


Arg Ile Gly Pro Asn Lys Pro Ser Leu Ser Gly Arg Gln Ala Pro Ala 
            20                  25                  30          


Gln Ala Gln Thr Ser Asp Leu Val Pro Ser Leu Phe Pro Leu Gly Leu 
        35                  40                  45              


Trp Ala Pro Gly Phe Cys Thr Trp Ser Ser Pro Asp Glu Asp Lys Arg 
    50                  55                  60                  


Pro Arg Lys Pro Val Pro Gly Thr Gly Asn Arg Asp Ser Gly Thr Arg 
65                  70                  75                  80  


Arg Arg Leu Gln Asp Ala Thr Glu Gln Asp Pro Arg Pro Gly Asn Asp 
                85                  90                  95      


Val Ala Ser Ala Glu Thr Ala Gly Pro Pro Ser Pro Ser Gly Ile Arg 
            100                 105                 110         


Ala Gln Asp Arg Ala Pro Arg His Arg Arg Ala Pro Pro Ala Arg Met 
        115                 120                 125             


Pro Val Ala Pro Ala Pro Ser Ala Asp Gly Gly Glu Arg Arg Ala Arg 
    130                 135                 140                 


Ala Gly Arg Gly Thr Arg Val Gly Gly Trp Gly Pro Lys Asp Pro Pro 
145                 150                 155                 160 


Phe Gln Gln Asn Pro His Arg Ser Arg Ala Arg Arg Gly Leu Gly Arg 
                165                 170                 175     


Ala Thr Ala Ala Gly Ala Leu His Ile Ser Thr Pro Pro Pro Glu Pro 
            180                 185                 190         


Leu Gln Glu Gln Gly Gly Gly Leu Phe His Arg Thr Arg Ser Val Tyr 
        195                 200                 205             


Asn Gly Leu Glu Leu Asn Thr Trp Met Lys Val Glu Arg Leu Phe Val 
    210                 215                 220                 


Glu Lys Phe His Gln Ser Phe Ser Leu Asp Asn 
225                 230                 235 


<210>  1938
<211>  202
<212>  PRT
<213>  Homo Sapiens

<400>  1938

Met Val Arg Ile Trp Thr Thr Ile Met Ile Val Leu Ile Leu Leu Leu 
1               5                   10                  15      


Arg Ile Gly Pro Asn Lys Pro Ser Leu Ser Gly Arg Gln Ala Pro Ala 
            20                  25                  30          


Gln Ala Gln Thr Ser Asp Leu Val Pro Ser Leu Phe Pro Leu Gly Leu 
        35                  40                  45              


Trp Ala Pro Gly Phe Cys Thr Trp Ser Ser Pro Asp Glu Asp Lys Val 
    50                  55                  60                  


Trp Arg Pro Ala Trp Glu Gln Gly Pro Lys Gly Glu Pro Asp Pro Arg 
65                  70                  75                  80  


Gly Leu Arg Pro Arg Lys Pro Val Pro Gly Thr Gly Asn Arg Asp Ser 
                85                  90                  95      


Gly Thr Arg Arg Arg Leu Gln Asp Ala Thr Glu Gln Asp Pro Arg Pro 
            100                 105                 110         


Gly Asn Asp Val Ala Ser Ala Glu Thr Ala Gly Pro Pro Ser Pro Ser 
        115                 120                 125             


Gly Ile Arg Ala Gln Asp Arg Ala Pro Arg His Arg Arg Ala Pro Pro 
    130                 135                 140                 


Ala Arg Met Pro Val Ala Pro Ala Pro Ser Ala Asp Gly Glu Pro Leu 
145                 150                 155                 160 


Gln Glu Gln Gly Gly Gly Leu Phe His Arg Thr Arg Ser Val Tyr Asn 
                165                 170                 175     


Gly Leu Glu Leu Asn Thr Trp Met Lys Val Glu Arg Leu Phe Val Glu 
            180                 185                 190         


Lys Phe His Gln Ser Phe Ser Leu Asp Asn 
        195                 200         


<210>  1939
<211>  56
<212>  PRT
<213>  Homo Sapiens

<400>  1939

His Val Ser Leu Arg Leu Asp Lys Glu His Leu Val Asn Ile Ser Gly 
1               5                   10                  15      


Gly Pro Met Thr Tyr Ser His Arg Leu Glu Glu Ile Arg Leu His Phe 
            20                  25                  30          


Gly Ser Glu Asp Ser Gln Gly Ser Glu His Leu Leu Asn Gly Gln Ala 
        35                  40                  45              


Phe Ser Gly Glu Glu Lys Val Cys 
    50                  55      


<210>  1940
<211>  328
<212>  PRT
<213>  Homo Sapiens

<400>  1940

Met Glu Ile Val Trp Glu Val Leu Phe Leu Leu Gln Ala Asn Phe Ile 
1               5                   10                  15      


Val Cys Ile Ser Ala Gln Gln Asn Ser Pro Lys Ile His Glu Gly Trp 
            20                  25                  30          


Trp Ala Tyr Lys Glu Val Val Gln Gly Ser Phe Val Pro Val Pro Ser 
        35                  40                  45              


Phe Trp Gly Leu Val Asn Ser Ala Trp Asn Leu Cys Ser Val Gly Lys 
    50                  55                  60                  


Arg Gln Ser Pro Val Asn Ile Glu Thr Ser His Met Ile Phe Asp Pro 
65                  70                  75                  80  


Phe Leu Thr Pro Leu Arg Ile Asn Thr Gly Gly Arg Lys Val Ser Gly 
                85                  90                  95      


Thr Met Tyr Asn Thr Gly Arg His Val Ser Leu Arg Leu Asp Lys Glu 
            100                 105                 110         


His Leu Val Asn Ile Ser Gly Gly Pro Met Thr Tyr Ser His Arg Leu 
        115                 120                 125             


Glu Glu Ile Arg Leu His Phe Gly Ser Glu Asp Ser Gln Gly Ser Glu 
    130                 135                 140                 


His Leu Leu Asn Gly Gln Ala Phe Ser Gly Glu Val Gln Leu Ile His 
145                 150                 155                 160 


Tyr Asn His Glu Leu Tyr Thr Asn Val Thr Glu Ala Ala Lys Ser Pro 
                165                 170                 175     


Asn Gly Leu Val Val Val Ser Ile Phe Ile Lys Val Ser Asp Ser Ser 
            180                 185                 190         


Asn Pro Phe Leu Asn Arg Met Leu Asn Arg Asp Thr Ile Thr Arg Ile 
        195                 200                 205             


Thr Tyr Lys Asn Asp Ala Tyr Leu Leu Gln Gly Leu Asn Ile Glu Glu 
    210                 215                 220                 


Leu Tyr Pro Glu Thr Ser Ser Phe Ile Thr Tyr Asp Gly Ser Met Thr 
225                 230                 235                 240 


Ile Pro Pro Cys Tyr Glu Thr Ala Ser Trp Ile Ile Met Asn Lys Pro 
                245                 250                 255     


Val Tyr Ile Thr Arg Met Gln Met His Ser Leu Arg Leu Leu Ser Gln 
            260                 265                 270         


Asn Gln Pro Ser Gln Ile Phe Leu Ser Met Ser Asp Asn Phe Arg Pro 
        275                 280                 285             


Val Gln Pro Leu Asn Asn Arg Cys Ile Arg Thr Asn Ile Asn Phe Ser 
    290                 295                 300                 


Leu Gln Gly Lys Asp Cys Pro Asn Asn Arg Ala Gln Lys Leu Gln Tyr 
305                 310                 315                 320 


Arg Val Asn Glu Trp Leu Leu Lys 
                325             


<210>  1941
<211>  328
<212>  PRT
<213>  Homo Sapiens

<400>  1941

Met Glu Ile Val Trp Glu Val Leu Phe Leu Leu Gln Ala Asn Phe Ile 
1               5                   10                  15      


Val Cys Ile Ser Ala Gln Gln Asn Ser Pro Lys Ile His Glu Gly Trp 
            20                  25                  30          


Trp Ala Tyr Lys Glu Val Val Gln Gly Ser Phe Val Pro Val Pro Ser 
        35                  40                  45              


Phe Trp Gly Leu Val Asn Ser Ala Trp Asn Leu Cys Ser Val Gly Lys 
    50                  55                  60                  


Arg Gln Ser Pro Val Asn Ile Glu Thr Ser His Met Ile Phe Asp Pro 
65                  70                  75                  80  


Phe Leu Thr Pro Leu Arg Ile Asn Thr Gly Gly Arg Lys Val Ser Gly 
                85                  90                  95      


Thr Met Tyr Asn Thr Gly Arg His Val Ser Leu Arg Leu Asp Lys Glu 
            100                 105                 110         


His Leu Val Asn Ile Ser Gly Gly Pro Met Thr Tyr Ser His Arg Leu 
        115                 120                 125             


Glu Glu Ile Arg Leu His Phe Gly Ser Glu Asp Ser Gln Gly Ser Glu 
    130                 135                 140                 


His Leu Leu Asn Gly Gln Ala Phe Ser Gly Glu Val Gln Leu Ile His 
145                 150                 155                 160 


Tyr Asn His Glu Leu Tyr Thr Asn Val Thr Glu Ala Ala Lys Ser Pro 
                165                 170                 175     


Asn Gly Leu Val Val Val Ser Ile Phe Ile Lys Val Ser Asp Ser Ser 
            180                 185                 190         


Asn Pro Phe Leu Asn Arg Met Leu Asn Arg Asp Thr Ile Thr Arg Ile 
        195                 200                 205             


Thr Tyr Lys Asn Asp Ala Tyr Leu Leu Gln Gly Leu Asn Ile Glu Glu 
    210                 215                 220                 


Leu Tyr Pro Glu Thr Ser Ser Phe Ile Thr Tyr Asp Gly Ser Met Thr 
225                 230                 235                 240 


Ile Pro Pro Cys Tyr Glu Thr Ala Ser Trp Ile Ile Met Asn Lys Pro 
                245                 250                 255     


Val Tyr Ile Thr Arg Met Gln Met His Ser Leu Arg Leu Leu Ser Gln 
            260                 265                 270         


Asn Gln Pro Ser Gln Ile Phe Leu Ser Met Ser Asp Asn Phe Arg Pro 
        275                 280                 285             


Val Gln Pro Leu Asn Asn Arg Cys Ile Arg Thr Asn Ile Asn Phe Ser 
    290                 295                 300                 


Leu Gln Gly Lys Asp Cys Pro Asn Asn Arg Ala Gln Lys Leu Gln Tyr 
305                 310                 315                 320 


Arg Val Asn Glu Trp Leu Leu Lys 
                325             


<210>  1942
<211>  328
<212>  PRT
<213>  Homo Sapiens

<400>  1942

Met Glu Ile Val Trp Glu Val Leu Phe Leu Leu Gln Ala Asn Phe Ile 
1               5                   10                  15      


Val Cys Ile Ser Ala Gln Gln Asn Ser Pro Lys Ile His Glu Gly Trp 
            20                  25                  30          


Trp Ala Tyr Lys Glu Val Val Gln Gly Ser Phe Val Pro Val Pro Ser 
        35                  40                  45              


Phe Trp Gly Leu Val Asn Ser Ala Trp Asn Leu Cys Ser Val Gly Lys 
    50                  55                  60                  


Arg Gln Ser Pro Val Asn Ile Glu Thr Ser His Met Ile Phe Asp Pro 
65                  70                  75                  80  


Phe Leu Thr Pro Leu Arg Ile Asn Thr Gly Gly Arg Lys Val Ser Gly 
                85                  90                  95      


Thr Met Tyr Asn Thr Gly Arg His Val Ser Leu Arg Leu Asp Lys Glu 
            100                 105                 110         


His Leu Val Asn Ile Ser Gly Gly Pro Met Thr Tyr Ser His Arg Leu 
        115                 120                 125             


Glu Glu Ile Arg Leu His Phe Gly Ser Glu Asp Ser Gln Gly Ser Glu 
    130                 135                 140                 


His Leu Leu Asn Gly Gln Ala Phe Ser Gly Glu Val Gln Leu Ile His 
145                 150                 155                 160 


Tyr Asn His Glu Leu Tyr Thr Asn Val Thr Glu Ala Ala Lys Ser Pro 
                165                 170                 175     


Asn Gly Leu Val Val Val Ser Ile Phe Ile Lys Val Ser Asp Ser Ser 
            180                 185                 190         


Asn Pro Phe Leu Asn Arg Met Leu Asn Arg Asp Thr Ile Thr Arg Ile 
        195                 200                 205             


Thr Tyr Lys Asn Asp Ala Tyr Leu Leu Gln Gly Leu Asn Ile Glu Glu 
    210                 215                 220                 


Leu Tyr Pro Glu Thr Ser Ser Phe Ile Thr Tyr Asp Gly Ser Met Thr 
225                 230                 235                 240 


Ile Pro Pro Cys Tyr Glu Thr Ala Ser Trp Ile Ile Met Asn Lys Pro 
                245                 250                 255     


Val Tyr Ile Thr Arg Met Gln Met His Ser Leu Arg Leu Leu Ser Gln 
            260                 265                 270         


Asn Gln Pro Ser Gln Ile Phe Leu Ser Met Ser Asp Asn Phe Arg Pro 
        275                 280                 285             


Val Gln Pro Leu Asn Asn Arg Cys Ile Arg Thr Asn Ile Asn Phe Ser 
    290                 295                 300                 


Leu Gln Gly Lys Asp Cys Pro Asn Asn Arg Ala Gln Lys Leu Gln Tyr 
305                 310                 315                 320 


Arg Val Asn Glu Trp Leu Leu Lys 
                325             


<210>  1943
<211>  276
<212>  PRT
<213>  Homo Sapiens

<400>  1943

Met Glu Ile Val Trp Glu Val Leu Phe Leu Leu Gln Ala Asn Phe Ile 
1               5                   10                  15      


Val Cys Ile Ser Ala Gln Gln Asn Ser Pro Lys Ile His Glu Gly Trp 
            20                  25                  30          


Trp Ala Tyr Lys Glu Val Val Gln Gly Ser Phe Val Pro Val Pro Ser 
        35                  40                  45              


Phe Trp Gly Leu Val Asn Ser Ala Trp Asn Leu Cys Ser Val Gly Lys 
    50                  55                  60                  


Arg Gln Ser Pro Val Asn Ile Glu Thr Ser His Met Ile Phe Asp Pro 
65                  70                  75                  80  


Phe Leu Thr Pro Leu Arg Ile Asn Thr Gly Gly Arg Lys Val Ser Gly 
                85                  90                  95      


Thr Met Tyr Asn Thr Gly Arg His Val Ser Leu Arg Leu Asp Lys Glu 
            100                 105                 110         


His Leu Val Asn Ile Ser Gly Gly Pro Met Thr Tyr Ser His Arg Leu 
        115                 120                 125             


Glu Glu Ile Arg Leu His Phe Gly Ser Glu Asp Ser Gln Gly Ser Glu 
    130                 135                 140                 


His Leu Leu Asn Gly Gln Ala Phe Ser Gly Glu Val Gln Leu Ile His 
145                 150                 155                 160 


Tyr Asn His Glu Leu Tyr Thr Asn Val Thr Glu Ala Ala Lys Ser Pro 
                165                 170                 175     


Asn Gly Leu Val Val Val Ser Ile Phe Ile Lys Val Ser Asp Ser Ser 
            180                 185                 190         


Asn Pro Phe Leu Asn Arg Met Leu Asn Arg Asp Thr Ile Thr Arg Ile 
        195                 200                 205             


Thr Tyr Lys Asn Asp Ala Tyr Leu Leu Gln Gly Leu Asn Ile Glu Glu 
    210                 215                 220                 


Leu Tyr Pro Glu Thr Ser Ser Phe Ile Thr Tyr Asp Gly Ser Met Thr 
225                 230                 235                 240 


Ile Pro Pro Cys Tyr Glu Thr Ala Ser Trp Ile Ile Met Asn Lys Pro 
                245                 250                 255     


Val Tyr Ile Thr Arg Met Gln Met His Ser Leu Arg Leu Leu Ser Gln 
            260                 265                 270         


Asn Gln Pro Ser 
        275     


<210>  1944
<211>  42
<212>  PRT
<213>  Homo Sapiens

<400>  1944

Met Glu Ile Val Trp Glu Val Leu Phe Leu Leu Gln Ala Asn Phe Ile 
1               5                   10                  15      


Val Cys Ile Ser Gly Asp Leu Arg Arg Ala Val Arg Arg Leu Trp Trp 
            20                  25                  30          


Gln Ser Gly Leu Glu Met Gln Val Thr Cys 
        35                  40          


<210>  1945
<211>  253
<212>  PRT
<213>  Homo Sapiens

<400>  1945

Met Ile Phe Asp Pro Phe Leu Thr Pro Leu Arg Ile Asn Thr Gly Gly 
1               5                   10                  15      


Arg Lys Val Ser Gly Thr Met Tyr Asn Thr Gly Arg His Val Ser Leu 
            20                  25                  30          


Arg Leu Asp Lys Glu His Leu Val Asn Ile Ser Gly Gly Pro Met Thr 
        35                  40                  45              


Tyr Ser His Arg Leu Glu Glu Ile Arg Leu His Phe Gly Ser Glu Asp 
    50                  55                  60                  


Ser Gln Gly Ser Glu His Leu Leu Asn Gly Gln Ala Phe Ser Gly Glu 
65                  70                  75                  80  


Val Gln Leu Ile His Tyr Asn His Glu Leu Tyr Thr Asn Val Thr Glu 
                85                  90                  95      


Ala Ala Lys Ser Pro Asn Gly Leu Val Val Val Ser Ile Phe Ile Lys 
            100                 105                 110         


Val Ser Asp Ser Ser Asn Pro Phe Leu Asn Arg Met Leu Asn Arg Asp 
        115                 120                 125             


Thr Ile Thr Arg Ile Thr Tyr Lys Asn Asp Ala Tyr Leu Leu Gln Gly 
    130                 135                 140                 


Leu Asn Ile Glu Glu Leu Tyr Pro Glu Thr Ser Ser Phe Ile Thr Tyr 
145                 150                 155                 160 


Asp Gly Ser Met Thr Ile Pro Pro Cys Tyr Glu Thr Ala Ser Trp Ile 
                165                 170                 175     


Ile Met Asn Lys Pro Val Tyr Ile Thr Arg Met Gln Met His Ser Leu 
            180                 185                 190         


Arg Leu Leu Ser Gln Asn Gln Pro Ser Gln Ile Phe Leu Ser Met Ser 
        195                 200                 205             


Asp Asn Phe Arg Pro Val Gln Pro Leu Asn Asn Arg Cys Ile Arg Thr 
    210                 215                 220                 


Asn Ile Asn Phe Ser Leu Gln Gly Lys Asp Cys Pro Asn Asn Arg Ala 
225                 230                 235                 240 


Gln Lys Leu Gln Tyr Arg Val Asn Glu Trp Leu Leu Lys 
                245                 250             


<210>  1946
<211>  328
<212>  PRT
<213>  Homo Sapiens

<400>  1946

Met Gly Ala Ala Ala Arg Leu Ser Ala Pro Arg Ala Leu Val Leu Trp 
1               5                   10                  15      


Ala Ala Leu Gly Ala Ala Ala His Ile Gly Pro Ala Pro Asp Pro Glu 
            20                  25                  30          


Asp Trp Trp Ser Tyr Lys Asp Asn Leu Gln Gly Asn Phe Val Pro Gly 
        35                  40                  45              


Pro Pro Phe Trp Gly Leu Val Asn Ala Ala Trp Ser Leu Cys Ala Val 
    50                  55                  60                  


Gly Lys Arg Gln Ser Pro Val Asp Val Glu Leu Lys Arg Val Leu Tyr 
65                  70                  75                  80  


Asp Pro Phe Leu Pro Pro Leu Arg Leu Ser Thr Gly Gly Glu Lys Leu 
                85                  90                  95      


Arg Gly Thr Leu Tyr Asn Thr Gly Arg His Val Ser Phe Leu Pro Ala 
            100                 105                 110         


Pro Arg Pro Val Val Asn Val Ser Gly Gly Pro Leu Leu Tyr Ser His 
        115                 120                 125             


Arg Leu Ser Glu Leu Arg Leu Leu Phe Gly Ala Arg Asp Gly Ala Gly 
    130                 135                 140                 


Ser Glu His Gln Ile Asn His Gln Gly Phe Ser Ala Glu Val Gln Leu 
145                 150                 155                 160 


Ile His Phe Asn Gln Glu Leu Tyr Gly Asn Phe Ser Ala Ala Ser Arg 
                165                 170                 175     


Gly Pro Asn Gly Leu Ala Ile Leu Ser Leu Phe Val Asn Val Ala Ser 
            180                 185                 190         


Thr Ser Asn Pro Phe Leu Ser Arg Leu Leu Asn Arg Asp Thr Ile Thr 
        195                 200                 205             


Arg Ile Ser Tyr Lys Asn Asp Ala Tyr Phe Leu Gln Asp Leu Ser Leu 
    210                 215                 220                 


Glu Leu Leu Phe Pro Glu Ser Phe Gly Phe Ile Thr Tyr Gln Gly Ser 
225                 230                 235                 240 


Leu Ser Thr Pro Pro Cys Ser Glu Thr Val Thr Trp Ile Leu Ile Asp 
                245                 250                 255     


Arg Ala Leu Asn Ile Thr Ser Leu Gln Met His Ser Leu Arg Leu Leu 
            260                 265                 270         


Ser Gln Asn Pro Pro Ser Gln Ile Phe Gln Ser Leu Ser Gly Asn Ser 
        275                 280                 285             


Arg Pro Leu Gln Pro Leu Ala His Arg Ala Leu Arg Gly Asn Arg Asp 
    290                 295                 300                 


Pro Arg His Pro Glu Arg Arg Cys Arg Gly Pro Asn Tyr Arg Leu His 
305                 310                 315                 320 


Val Asp Gly Val Pro His Gly Arg 
                325             


<210>  1947
<211>  113
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1947

Xaa Asp Ala Tyr Phe Leu Gln Asp Leu Ser Leu Glu Leu Leu Phe Pro 
1               5                   10                  15      


Glu Ser Phe Gly Phe Ile Thr Tyr Gln Gly Ser Leu Ser Thr Pro Pro 
            20                  25                  30          


Cys Ser Glu Thr Val Thr Trp Ile Leu Ile Asp Arg Ala Leu Asn Ile 
        35                  40                  45              


Thr Ser Leu Gln Met His Ser Leu Arg Leu Leu Ser Gln Asn Pro Pro 
    50                  55                  60                  


Ser Gln Ile Phe Gln Ser Leu Ser Gly Asn Ser Arg Pro Leu Gln Pro 
65                  70                  75                  80  


Leu Ala His Arg Ala Leu Arg Gly Asn Arg Asp Pro Arg His Pro Glu 
                85                  90                  95      


Arg Arg Cys Arg Gly Pro Asn Tyr Arg Leu His Ala Gln Cys Phe Ser 
            100                 105                 110         


Thr 
    


<210>  1948
<211>  187
<212>  PRT
<213>  Homo Sapiens

<400>  1948

Met Arg Ala Leu Val Leu Leu Leu Ser Leu Phe Leu Leu Gly Gly Gln 
1               5                   10                  15      


Ala Gln His Val Ser Asp Trp Thr Tyr Ser Glu Gly Ala Leu Asp Glu 
            20                  25                  30          


Ala His Trp Pro Gln His Tyr Pro Ala Cys Gly Gly Gln Arg Gln Ser 
        35                  40                  45              


Pro Ile Asn Leu Gln Arg Thr Lys Ile Ser Leu Pro Ser Thr Met Arg 
    50                  55                  60                  


Met Thr Val Ala Asp Gly Thr Val Tyr Ile Ala Gln Gln Met His Phe 
65                  70                  75                  80  


His Trp Gly Gly Ala Ser Ser Glu Ile Ser Gly Ser Glu His Thr Val 
                85                  90                  95      


Asp Gly Ile Arg His Val Ile Glu Ile His Ile Val His Tyr Asn Ser 
            100                 105                 110         


Lys Tyr Lys Ser Tyr Asp Ile Ala Gln Asp Ala Pro Asp Gly Leu Ala 
        115                 120                 125             


Val Leu Ala Ala Phe Val Glu Val Lys Asn Tyr Pro Glu Asn Thr Tyr 
    130                 135                 140                 


Tyr Ser Asn Phe Ile Ser His Leu Ala Asn Ile Lys Tyr Pro Gly Gln 
145                 150                 155                 160 


Arg Thr Thr Leu Thr Gly Leu Asp Val Gln Asp Met Leu Pro Arg Asn 
                165                 170                 175     


Leu Gln His Tyr Tyr Thr Tyr His Gly Ser Leu 
            180                 185         


<210>  1949
<211>  179
<212>  PRT
<213>  Homo Sapiens

<400>  1949

Met Arg Ala Leu Val Leu Leu Leu Ser Leu Phe Leu Leu Gly Gly Gln 
1               5                   10                  15      


Ala Gln His Val Ser Asp Trp Thr Tyr Ser Glu Gly Ala Leu Asp Glu 
            20                  25                  30          


Ala His Trp Pro Gln His Tyr Pro Ala Cys Gly Gly Gln Arg Gln Ser 
        35                  40                  45              


Pro Ile Asn Leu Gln Arg Thr Lys Val Arg Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Gly Leu Asn Met Thr Gly Tyr Glu Thr Gln Ala Gly Glu Phe Pro Met 
65                  70                  75                  80  


Val Asn Asn Gly His Thr Asp Trp Gln Ala Glu Leu Phe Leu Pro Ser 
                85                  90                  95      


Leu Ser Ser Pro Cys Gly Glu Gly Ala Lys His Lys Gly Gln Arg Gln 
            100                 105                 110         


Trp Leu Cys Ser Pro Ser Leu Asp Ser Trp Trp Glu Ala Ile Ile Asp 
        115                 120                 125             


Gly Gly Ser Leu Trp Ala Thr Leu Ala Glu Cys Gly Leu Arg Ala Glu 
    130                 135                 140                 


Gly Pro Glu Glu Gly Arg His Met Glu Glu Lys Ser Pro Ala Ser Gln 
145                 150                 155                 160 


Gly Ala Cys Ser Gly Ser Arg Leu Pro Ile Ser Arg Gly Pro Cys Thr 
                165                 170                 175     


Phe Phe Leu 
            


<210>  1950
<211>  313
<212>  PRT
<213>  Homo Sapiens

<400>  1950

Met Arg Ala Leu Val Leu Leu Leu Ser Leu Phe Leu Leu Gly Gly Gln 
1               5                   10                  15      


Ala Gln His Val Ser Asp Trp Thr Tyr Ser Glu Gly Ala Leu Asp Glu 
            20                  25                  30          


Ala His Trp Pro Gln His Tyr Pro Ala Cys Gly Gly Gln Arg Gln Ser 
        35                  40                  45              


Pro Ile Asn Leu Gln Arg Thr Lys Val Arg Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Gly Leu Asn Met Thr Gly Tyr Glu Thr Gln Ala Gly Glu Phe Pro Met 
65                  70                  75                  80  


Val Asn Asn Gly His Thr Val Gln Ile Ser Leu Pro Ser Thr Met Arg 
                85                  90                  95      


Met Thr Val Ala Asp Gly Thr Val Tyr Ile Ala Gln Gln Met His Phe 
            100                 105                 110         


His Trp Gly Gly Ala Ser Ser Glu Ile Ser Gly Ser Glu His Thr Val 
        115                 120                 125             


Asp Gly Ile Arg His Val Ile Glu Ile His Ile Val His Tyr Asn Ser 
    130                 135                 140                 


Lys Tyr Lys Ser Tyr Asp Ile Ala Gln Asp Ala Pro Asp Gly Leu Ala 
145                 150                 155                 160 


Val Leu Ala Ala Phe Val Glu Val Lys Asn Tyr Pro Glu Asn Thr Tyr 
                165                 170                 175     


Tyr Ser Asn Phe Ile Ser His Leu Ala Asn Ile Lys Tyr Pro Gly Gln 
            180                 185                 190         


Arg Thr Thr Leu Thr Gly Leu Asp Val Gln Asp Met Leu Pro Arg Asn 
        195                 200                 205             


Leu Gln His Tyr Tyr Thr Tyr His Gly Ser Leu Thr Thr Pro Pro Cys 
    210                 215                 220                 


Thr Glu Asn Val His Trp Phe Val Leu Ala Asp Phe Val Lys Leu Ser 
225                 230                 235                 240 


Arg Thr Gln Val Trp Lys Leu Glu Asn Ser Leu Leu Asp His Arg Asn 
                245                 250                 255     


Lys Thr Ile His Asn Asp Tyr Arg Arg Thr Gln Pro Leu Asn His Arg 
            260                 265                 270         


Val Val Glu Ser Asn Phe Pro Asn Gln Gly Lys Gly His Gly Gly His 
        275                 280                 285             


Arg Gly Arg Ser Gln Asn Pro Arg Val Gln Pro Thr Ser Thr Arg His 
    290                 295                 300                 


Pro Leu Ala Leu Gly Ser Leu Glu Ala 
305                 310             


<210>  1951
<211>  308
<212>  PRT
<213>  Homo Sapiens

<400>  1951

Met Arg Ala Leu Val Leu Leu Leu Ser Leu Phe Leu Leu Gly Gly Gln 
1               5                   10                  15      


Ala Gln His Val Ser Asp Trp Thr Tyr Ser Glu Gly Ala Leu Asp Glu 
            20                  25                  30          


Ala His Trp Pro Gln His Tyr Pro Ala Cys Gly Gly Gln Arg Gln Ser 
        35                  40                  45              


Pro Ile Asn Leu Gln Arg Thr Lys Val Arg Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Gly Leu Asn Met Thr Gly Tyr Glu Thr Gln Ala Gly Glu Phe Pro Met 
65                  70                  75                  80  


Val Asn Asn Gly His Thr Val Gln Ile Ser Leu Pro Ser Thr Met Arg 
                85                  90                  95      


Met Thr Val Ala Asp Gly Thr Val Tyr Ile Ala Gln Gln Met His Phe 
            100                 105                 110         


His Trp Gly Gly Ala Ser Ser Glu Ile Ser Gly Ser Glu His Thr Val 
        115                 120                 125             


Asp Gly Ile Arg His Val Ile Glu Ile His Ile Val His Tyr Asn Ser 
    130                 135                 140                 


Lys Tyr Lys Ser Tyr Asp Ile Ala Gln Asp Ala Pro Asp Gly Leu Ala 
145                 150                 155                 160 


Val Leu Ala Ala Phe Val Glu Val Lys Asn Tyr Pro Glu Asn Thr Tyr 
                165                 170                 175     


Tyr Ser Asn Phe Ile Ser His Leu Ala Asn Ile Lys Tyr Pro Gly Gln 
            180                 185                 190         


Arg Thr Thr Leu Thr Gly Leu Asp Val Gln Asp Met Leu Pro Arg Asn 
        195                 200                 205             


Leu Gln His Tyr Tyr Thr Tyr His Gly Ser Leu Thr Thr Pro Pro Cys 
    210                 215                 220                 


Thr Glu Asn Val His Trp Phe Val Leu Ala Asp Phe Val Lys Leu Ser 
225                 230                 235                 240 


Arg Thr Gln Val Trp Lys Leu Glu Asn Ser Leu Leu Asp His Arg Asn 
                245                 250                 255     


Lys Thr Ile His Asn Asp Tyr Arg Arg Thr Gln Pro Leu Asn His Arg 
            260                 265                 270         


Val Val Glu Ser Asn Phe Pro Asn Gln Glu Tyr Thr Leu Gly Ser Glu 
        275                 280                 285             


Phe Gln Phe Tyr Leu His Lys Ile Glu Glu Ile Leu Asp Tyr Leu Arg 
    290                 295                 300                 


Arg Ala Leu Asn 
305             


<210>  1952
<211>  248
<212>  PRT
<213>  Homo Sapiens

<400>  1952

Met Arg Ala Leu Val Leu Leu Leu Ser Leu Phe Leu Leu Gly Gly Gln 
1               5                   10                  15      


Ala Gln His Val Ser Asp Trp Thr Tyr Ser Val Gln Ile Ser Leu Pro 
            20                  25                  30          


Ser Thr Met Arg Met Thr Val Ala Asp Gly Thr Val Tyr Ile Ala Gln 
        35                  40                  45              


Gln Met His Phe His Trp Gly Gly Ala Ser Ser Glu Ile Ser Gly Ser 
    50                  55                  60                  


Glu His Thr Val Asp Gly Ile Arg His Val Ile Glu Ile His Ile Val 
65                  70                  75                  80  


His Tyr Asn Ser Lys Tyr Lys Ser Tyr Asp Ile Ala Gln Asp Ala Pro 
                85                  90                  95      


Asp Gly Leu Ala Val Leu Ala Ala Phe Val Glu Val Lys Asn Tyr Pro 
            100                 105                 110         


Glu Asn Thr Tyr Tyr Ser Asn Phe Ile Ser His Leu Ala Asn Ile Lys 
        115                 120                 125             


Tyr Pro Gly Gln Arg Thr Thr Leu Thr Gly Leu Asp Val Gln Asp Met 
    130                 135                 140                 


Leu Pro Arg Asn Leu Gln His Tyr Tyr Thr Tyr His Gly Ser Leu Thr 
145                 150                 155                 160 


Thr Pro Pro Cys Thr Glu Asn Val His Trp Phe Val Leu Ala Asp Phe 
                165                 170                 175     


Val Lys Leu Ser Arg Thr Gln Val Trp Lys Leu Glu Asn Ser Leu Leu 
            180                 185                 190         


Asp His Arg Asn Lys Thr Ile His Asn Asp Tyr Arg Arg Thr Gln Pro 
        195                 200                 205             


Leu Asn His Arg Val Val Glu Ser Asn Phe Pro Asn Gln Glu Tyr Thr 
    210                 215                 220                 


Leu Gly Ser Glu Phe Gln Phe Tyr Leu His Lys Ile Glu Glu Ile Leu 
225                 230                 235                 240 


Asp Tyr Leu Arg Arg Ala Leu Asn 
                245             


<210>  1953
<211>  459
<212>  PRT
<213>  Homo Sapiens

<400>  1953

Met Ala Pro Leu Cys Pro Ser Pro Trp Leu Pro Leu Leu Ile Pro Ala 
1               5                   10                  15      


Pro Ala Pro Gly Leu Thr Val Gln Leu Leu Leu Ser Leu Leu Leu Leu 
            20                  25                  30          


Val Pro Val His Pro Gln Arg Leu Pro Arg Met Gln Glu Asp Ser Pro 
        35                  40                  45              


Leu Gly Gly Gly Ser Ser Gly Glu Asp Asp Pro Leu Gly Glu Glu Asp 
    50                  55                  60                  


Leu Pro Ser Glu Glu Asp Ser Pro Arg Glu Glu Asp Pro Pro Gly Glu 
65                  70                  75                  80  


Glu Asp Leu Pro Gly Glu Glu Asp Leu Pro Gly Glu Glu Asp Leu Pro 
                85                  90                  95      


Glu Val Lys Pro Lys Ser Glu Glu Glu Gly Ser Leu Lys Leu Glu Asp 
            100                 105                 110         


Leu Pro Thr Val Glu Ala Pro Gly Asp Pro Gln Glu Pro Gln Asn Asn 
        115                 120                 125             


Ala His Arg Asp Lys Glu Gly Asp Asp Gln Ser His Trp Arg Tyr Gly 
    130                 135                 140                 


Gly Asp Pro Pro Trp Pro Arg Val Ser Pro Ala Cys Ala Gly Arg Phe 
145                 150                 155                 160 


Gln Ser Pro Val Asp Ile Arg Pro Gln Leu Ala Ala Phe Cys Pro Ala 
                165                 170                 175     


Leu Arg Pro Leu Glu Leu Leu Gly Phe Gln Leu Pro Pro Leu Pro Glu 
            180                 185                 190         


Leu Arg Leu Arg Asn Asn Gly His Ser Val Gln Leu Thr Leu Pro Pro 
        195                 200                 205             


Gly Leu Glu Met Ala Leu Gly Pro Gly Arg Glu Tyr Arg Ala Leu Gln 
    210                 215                 220                 


Leu His Leu His Trp Gly Ala Ala Gly Arg Pro Gly Ser Glu His Thr 
225                 230                 235                 240 


Val Glu Gly His Arg Phe Pro Ala Glu Ile His Val Val His Leu Ser 
                245                 250                 255     


Thr Ala Phe Ala Arg Val Asp Glu Ala Leu Gly Arg Pro Gly Gly Leu 
            260                 265                 270         


Ala Val Leu Ala Ala Phe Leu Glu Glu Gly Pro Glu Glu Asn Ser Ala 
        275                 280                 285             


Tyr Glu Gln Leu Leu Ser Arg Leu Glu Glu Ile Ala Glu Glu Gly Ser 
    290                 295                 300                 


Glu Thr Gln Val Pro Gly Leu Asp Ile Ser Ala Leu Leu Pro Ser Asp 
305                 310                 315                 320 


Phe Ser Arg Tyr Phe Gln Tyr Glu Gly Ser Leu Thr Thr Pro Pro Cys 
                325                 330                 335     


Ala Gln Gly Val Ile Trp Thr Val Phe Asn Gln Thr Val Met Leu Ser 
            340                 345                 350         


Ala Lys Gln Leu His Thr Leu Ser Asp Thr Leu Trp Gly Pro Gly Asp 
        355                 360                 365             


Ser Arg Leu Gln Leu Asn Phe Arg Ala Thr Gln Pro Leu Asn Gly Arg 
    370                 375                 380                 


Val Ile Glu Ala Ser Phe Pro Ala Gly Val Asp Ser Ser Pro Arg Ala 
385                 390                 395                 400 


Ala Glu Pro Val Gln Leu Asn Ser Cys Leu Ala Ala Gly Asp Ile Leu 
                405                 410                 415     


Ala Leu Val Phe Gly Leu Leu Phe Ala Val Thr Ser Val Ala Phe Leu 
            420                 425                 430         


Val Gln Met Arg Arg Gln His Arg Arg Gly Thr Lys Gly Gly Val Ser 
        435                 440                 445             


Tyr Arg Pro Ala Glu Val Ala Glu Thr Gly Ala 
    450                 455                 


<210>  1954
<211>  356
<212>  PRT
<213>  Homo Sapiens

<400>  1954

Met Ala Pro Leu Cys Pro Ser Pro Trp Leu Pro Leu Leu Ile Pro Ala 
1               5                   10                  15      


Pro Ala Pro Gly Leu Thr Val Gln Leu Leu Leu Ser Leu Leu Leu Leu 
            20                  25                  30          


Val Pro Val His Pro Gln Arg Leu Pro Arg Met Gln Glu Asp Ser Pro 
        35                  40                  45              


Leu Gly Gly Gly Ser Ser Gly Glu Asp Asp Pro Leu Gly Glu Glu Asp 
    50                  55                  60                  


Leu Pro Ser Glu Glu Asp Ser Pro Arg Glu Glu Asp Pro Pro Gly Glu 
65                  70                  75                  80  


Glu Asp Leu Pro Gly Glu Glu Asp Leu Pro Gly Glu Glu Asp Leu Pro 
                85                  90                  95      


Glu Val Lys Pro Lys Ser Glu Glu Glu Gly Ser Leu Lys Leu Glu Asp 
            100                 105                 110         


Leu Pro Thr Val Glu Ala Pro Gly Asp Pro Gln Glu Pro Gln Asn Asn 
        115                 120                 125             


Ala His Arg Asp Lys Glu Gly Asp Asp Gln Ser His Trp Arg Tyr Gly 
    130                 135                 140                 


Gly Asp Pro Pro Trp Pro Arg Val Ser Pro Ala Cys Ala Gly Arg Phe 
145                 150                 155                 160 


Gln Ser Pro Val Asp Ile Arg Pro Gln Leu Ala Ala Phe Cys Pro Ala 
                165                 170                 175     


Leu Arg Pro Leu Glu Leu Leu Gly Phe Gln Leu Pro Pro Leu Pro Glu 
            180                 185                 190         


Leu Arg Leu Arg Asn Asn Gly His Ser Val Gln Leu Thr Leu Pro Pro 
        195                 200                 205             


Gly Leu Glu Met Ala Leu Gly Pro Gly Arg Glu Tyr Arg Ala Leu Gln 
    210                 215                 220                 


Leu His Leu His Trp Gly Ala Ala Gly Arg Pro Gly Ser Glu His Thr 
225                 230                 235                 240 


Val Glu Gly His Arg Phe Pro Ala Glu Ile His Val Val His Leu Ser 
                245                 250                 255     


Thr Ala Phe Ala Arg Val Asp Glu Ala Leu Gly Arg Pro Gly Gly Leu 
            260                 265                 270         


Ala Val Leu Ala Ala Phe Leu Glu Glu Gly Pro Glu Glu Asn Ser Ala 
        275                 280                 285             


Tyr Glu Gln Leu Leu Ser Arg Leu Glu Glu Ile Ala Glu Glu Gly Ser 
    290                 295                 300                 


Glu Thr Gln Val Pro Gly Leu Asp Ile Ser Ala Leu Leu Pro Ser Asp 
305                 310                 315                 320 


Phe Ser Arg Tyr Phe Gln Tyr Glu Gly Ser Leu Thr Thr Pro Pro Cys 
                325                 330                 335     


Ala Gln Gly Val Ile Trp Thr Val Phe Asn Gln Thr Val Met Leu Ser 
            340                 345                 350         


Ala Lys Gln Ser 
        355     


<210>  1955
<211>  633
<212>  PRT
<213>  Homo Sapiens

<400>  1955

Met Ala Ala Ala Ala Ala Ala Ala Thr Thr Ala Ala Cys Ser Ser Gly 
1               5                   10                  15      


Ser Ala Gly Thr Asp Ala Ala Gly Ala Ser Gly Leu Gln Gln Pro Pro 
            20                  25                  30          


Pro Gln Pro Gln Pro Gln Pro Ala Ala Ala Ala Pro Ala Gln Pro Pro 
        35                  40                  45              


Pro Glu Pro Pro Arg Lys Pro Arg Met Asp Pro Arg Arg Arg Gln Ala 
    50                  55                  60                  


Ala Leu Ser Phe Leu Thr Asn Ile Ser Leu Asp Gly Arg Leu Pro Pro 
65                  70                  75                  80  


Gln Asp Ala Glu Trp Gly Gly Gly Glu Glu Gly Gly Ala Ala Lys Pro 
                85                  90                  95      


Gly Ala Gly Gly Ala Cys Gly Ala Arg Thr Arg Phe Ser Leu Leu Ala 
            100                 105                 110         


Ala Ala Glu Arg Gly Gly Cys Ile Ala Leu Ala Ala Pro Gly Thr Pro 
        115                 120                 125             


Ala Ala Gly Leu Ala Ala Gly Ser Gly Pro Cys Leu Pro Gln Pro Ser 
    130                 135                 140                 


Ser Leu Pro Pro Leu Ile Pro Gly Gly His Ala Thr Val Ser Gly Pro 
145                 150                 155                 160 


Gly Val Ala Arg Gly Phe Ala Ser Pro Leu Gly Ala Gly Arg Ala Ser 
                165                 170                 175     


Gly Glu Gln Trp Gln Pro Pro Arg Pro Ala Pro Leu Ala Ala Cys Ala 
            180                 185                 190         


Gln Leu Gln Leu Leu Asp Gly Ser Gly Ala Ala Gly Gln Glu Glu Leu 
        195                 200                 205             


Glu Glu Asp Asp Ala Phe Ile Ser Val Gln Val Pro Ala Ala Ala Phe 
    210                 215                 220                 


Leu Gly Ser Gly Thr Pro Gly Ser Gly Ser Gly Ser Arg Gly Arg Leu 
225                 230                 235                 240 


Asn Ser Phe Thr Gln Gly Ile Leu Pro Ile Ala Phe Ser Arg Pro Thr 
                245                 250                 255     


Ser Gln Asn Tyr Cys Ser Leu Glu Gln Pro Gly Gln Gly Gly Ser Thr 
            260                 265                 270         


Ser Ala Phe Glu Gln Leu Gln Arg Ser Arg Arg Arg Leu Ile Ser Gln 
        275                 280                 285             


Arg Ser Ser Leu Glu Thr Leu Glu Asp Ile Glu Glu Asn Ala Pro Leu 
    290                 295                 300                 


Arg Arg Cys Arg Thr Leu Ser Gly Ser Pro Arg Pro Lys Asn Phe Lys 
305                 310                 315                 320 


Lys Ile His Phe Ile Lys Asn Met Arg Gln His Asp Thr Arg Asn Gly 
                325                 330                 335     


Arg Ile Val Leu Ile Ser Gly Arg Arg Ser Phe Cys Ser Ile Phe Ser 
            340                 345                 350         


Val Leu Pro Tyr Arg Asp Ser Thr Gln Val Gly Asp Leu Lys Leu Asp 
        355                 360                 365             


Gly Gly Arg Gln Ser Thr Gly Ala Val Ser Leu Lys Glu Ile Ile Gly 
    370                 375                 380                 


Leu Glu Gly Val Glu Leu Gly Ala Asp Gly Lys Thr Val Ser Tyr Thr 
385                 390                 395                 400 


Gln Phe Leu Leu Pro Thr Asn Ala Phe Gly Ala Arg Arg Asn Thr Ile 
                405                 410                 415     


Asp Ser Thr Ser Ser Phe Ser Gln Phe Arg Asn Leu Ser His Arg Ser 
            420                 425                 430         


Leu Ser Ile Gly Arg Ala Ser Gly Thr Gln Gly Ser Leu Asp Thr Gly 
        435                 440                 445             


Ser Asp Leu Gly Asp Phe Met Asp Tyr Asp Pro Asn Leu Leu Asp Asp 
    450                 455                 460                 


Pro Gln Trp Pro Cys Gly Lys His Lys Arg Val Leu Ile Phe Pro Ser 
465                 470                 475                 480 


Tyr Met Thr Thr Val Ile Asp Tyr Val Lys Pro Ser Asp Leu Lys Lys 
                485                 490                 495     


Asp Met Asn Glu Thr Phe Lys Glu Lys Phe Pro His Ile Lys Leu Thr 
            500                 505                 510         


Leu Ser Lys Ile Arg Ser Leu Lys Arg Glu Met Arg Lys Leu Ala Gln 
        515                 520                 525             


Glu Asp Cys Gly Leu Glu Glu Pro Thr Val Ala Met Ala Phe Val Tyr 
    530                 535                 540                 


Phe Glu Lys Leu Ala Leu Lys Gly Lys Leu Asn Lys Gln Asn Arg Lys 
545                 550                 555                 560 


Leu Cys Ala Gly Ala Cys Val Leu Leu Ala Ala Lys Ile Gly Ser Asp 
                565                 570                 575     


Leu Lys Lys His Glu Val Lys His Leu Ile Asp Lys Leu Glu Glu Lys 
            580                 585                 590         


Phe Arg Leu Asn Arg Arg Glu Leu Ile Ala Phe Glu Phe Pro Val Leu 
        595                 600                 605             


Val Ala Leu Glu Phe Ala Leu His Leu Pro Glu His Glu Val Met Pro 
    610                 615                 620                 


His Tyr Arg Arg Leu Val Gln Ser Ser 
625                 630             


<210>  1956
<211>  368
<212>  PRT
<213>  Homo Sapiens

<400>  1956

Met Leu Ser Lys Arg Gly Cys His Ala Arg Ile Tyr Ala Asp Phe Pro 
1               5                   10                  15      


Ile Arg Arg Leu Ile Ser Gln Arg Ser Ser Leu Glu Thr Leu Glu Asp 
            20                  25                  30          


Ile Glu Glu Asn Ala Pro Leu Arg Arg Cys Arg Thr Leu Ser Gly Ser 
        35                  40                  45              


Pro Arg Pro Lys Asn Phe Lys Lys Ile His Phe Ile Lys Asn Met Arg 
    50                  55                  60                  


Gln His Asp Thr Arg Asn Gly Arg Ile Val Leu Ile Ser Gly Arg Arg 
65                  70                  75                  80  


Ser Phe Cys Ser Ile Phe Ser Val Leu Pro Tyr Arg Asp Ser Thr Gln 
                85                  90                  95      


Val Gly Asp Leu Lys Leu Asp Gly Gly Arg Gln Ser Thr Gly Ala Val 
            100                 105                 110         


Ser Leu Lys Glu Ile Ile Gly Leu Glu Gly Val Glu Leu Gly Ala Asp 
        115                 120                 125             


Gly Lys Thr Val Ser Tyr Thr Gln Phe Leu Leu Pro Thr Asn Ala Phe 
    130                 135                 140                 


Gly Ala Arg Arg Asn Thr Ile Asp Ser Thr Ser Ser Phe Ser Gln Phe 
145                 150                 155                 160 


Arg Asn Leu Ser His Arg Ser Leu Ser Ile Gly Arg Ala Ser Gly Thr 
                165                 170                 175     


Gln Gly Ser Leu Asp Thr Gly Ser Asp Leu Gly Asp Phe Met Asp Tyr 
            180                 185                 190         


Asp Pro Asn Leu Leu Asp Asp Pro Gln Trp Pro Cys Gly Lys His Lys 
        195                 200                 205             


Arg Val Leu Ile Phe Pro Ser Tyr Met Thr Thr Val Ile Asp Tyr Val 
    210                 215                 220                 


Lys Pro Ser Asp Leu Lys Lys Asp Met Asn Glu Thr Phe Lys Glu Lys 
225                 230                 235                 240 


Phe Pro His Ile Lys Leu Thr Leu Ser Lys Ile Arg Ser Leu Lys Arg 
                245                 250                 255     


Glu Met Arg Lys Leu Ala Gln Glu Asp Cys Gly Leu Glu Glu Pro Thr 
            260                 265                 270         


Val Ala Met Ala Phe Val Tyr Phe Glu Lys Leu Ala Leu Lys Gly Lys 
        275                 280                 285             


Leu Asn Lys Gln Asn Arg Lys Leu Cys Ala Gly Ala Cys Val Leu Leu 
    290                 295                 300                 


Ala Ala Lys Ile Gly Ser Asp Leu Lys Lys His Glu Val Lys His Leu 
305                 310                 315                 320 


Ile Asp Lys Leu Glu Glu Lys Phe Arg Leu Asn Arg Arg Glu Leu Ile 
                325                 330                 335     


Ala Phe Glu Phe Pro Val Leu Val Ala Leu Glu Phe Ala Leu His Leu 
            340                 345                 350         


Pro Glu His Glu Val Met Pro His Tyr Arg Arg Leu Val Gln Ser Ser 
        355                 360                 365             


<210>  1957
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  1957

Met Arg Gln His Asp Thr Arg Asn Gly 
1               5                   


<210>  1958
<211>  306
<212>  PRT
<213>  Homo Sapiens

<400>  1958

Met Arg Gln His Asp Thr Arg Asn Gly Arg Ile Val Leu Ile Ser Gly 
1               5                   10                  15      


Arg Arg Ser Phe Cys Ser Ile Phe Ser Val Leu Pro Tyr Arg Asp Ser 
            20                  25                  30          


Thr Gln Val Gly Asp Leu Lys Leu Asp Gly Gly Arg Gln Ser Thr Gly 
        35                  40                  45              


Ala Val Ser Leu Lys Glu Ile Ile Gly Leu Glu Gly Val Glu Leu Gly 
    50                  55                  60                  


Ala Asp Gly Lys Thr Val Ser Tyr Thr Gln Phe Leu Leu Pro Thr Asn 
65                  70                  75                  80  


Ala Phe Gly Ala Arg Arg Asn Thr Ile Asp Ser Thr Ser Ser Phe Ser 
                85                  90                  95      


Gln Phe Arg Asn Leu Ser His Arg Ser Leu Ser Ile Gly Arg Ala Ser 
            100                 105                 110         


Gly Thr Gln Gly Ser Leu Asp Thr Gly Ser Asp Leu Gly Asp Phe Met 
        115                 120                 125             


Asp Tyr Asp Pro Asn Leu Leu Asp Asp Pro Gln Trp Pro Cys Gly Lys 
    130                 135                 140                 


His Lys Arg Val Leu Ile Phe Pro Ser Tyr Met Thr Thr Val Ile Asp 
145                 150                 155                 160 


Tyr Val Lys Pro Ser Asp Leu Lys Lys Asp Met Asn Glu Thr Phe Lys 
                165                 170                 175     


Glu Lys Phe Pro His Ile Lys Leu Thr Leu Ser Lys Ile Arg Ser Leu 
            180                 185                 190         


Lys Arg Glu Met Arg Lys Leu Ala Gln Glu Asp Cys Gly Leu Glu Glu 
        195                 200                 205             


Pro Thr Val Ala Met Ala Phe Val Tyr Phe Glu Lys Leu Ala Leu Lys 
    210                 215                 220                 


Gly Lys Leu Asn Lys Gln Asn Arg Lys Leu Cys Ala Gly Ala Cys Val 
225                 230                 235                 240 


Leu Leu Ala Ala Lys Ile Gly Ser Asp Leu Lys Lys His Glu Val Lys 
                245                 250                 255     


His Leu Ile Asp Lys Leu Glu Glu Lys Phe Arg Leu Asn Arg Arg Glu 
            260                 265                 270         


Leu Ile Ala Phe Glu Phe Pro Val Leu Val Ala Leu Glu Phe Ala Leu 
        275                 280                 285             


His Leu Pro Glu His Glu Val Met Pro His Tyr Arg Arg Leu Val Gln 
    290                 295                 300                 


Ser Ser 
305     


<210>  1959
<211>  38
<212>  PRT
<213>  Homo Sapiens

<400>  1959

Met Arg Gln His Asp Thr Arg Asn Gly Arg Ile Val Leu Ile Ser Gly 
1               5                   10                  15      


Arg Arg Ser Phe Cys Ser Ile Phe Ser Val Leu Pro Tyr Arg Asp Ser 
            20                  25                  30          


Thr Gln Val Gly Gln Gln 
        35              


<210>  1960
<211>  163
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1960

Xaa Ala Ala Phe Leu Gly Ser Gly Thr Pro Gly Ser Gly Ser Gly Ser 
1               5                   10                  15      


Arg Gly Arg Leu Asn Ser Phe Thr Gln Gly Ile Leu Pro Ile Ala Phe 
            20                  25                  30          


Ser Arg Pro Thr Ser Gln Asn Tyr Cys Ser Leu Glu Gln Pro Gly Gln 
        35                  40                  45              


Gly Gly Ser Thr Ser Ala Phe Glu Gln Leu Gln Arg Ser Arg Arg Arg 
    50                  55                  60                  


Leu Ile Ser Gln Arg Ser Ser Leu Glu Thr Leu Glu Asp Ile Glu Glu 
65                  70                  75                  80  


Asn Ala Pro Leu Arg Arg Cys Arg Thr Leu Ser Gly Ser Pro Arg Pro 
                85                  90                  95      


Lys Asn Phe Lys Lys Ile His Phe Ile Lys Asn Met Arg Gln His Asp 
            100                 105                 110         


Thr Arg Asn Gly Arg Ile Val Leu Ile Ser Gly Arg Arg Ser Phe Cys 
        115                 120                 125             


Ser Ile Phe Ser Val Leu Pro Tyr Arg Asp Ser Thr Gln Val Gly Tyr 
    130                 135                 140                 


Val Tyr Ala Cys Met Leu Cys Ser Ser Leu Gly Glu Lys Ile Ser His 
145                 150                 155                 160 


Gln Cys Thr 
            


<210>  1961
<211>  306
<212>  PRT
<213>  Homo Sapiens

<400>  1961

Met Cys Gln Cys Val Arg Ala Cys Val Cys Val Cys Val Cys Ala Cys 
1               5                   10                  15      


Ala Thr Gln Arg Ala Ser His Ser Ala Leu Pro Gly Thr Thr Ile Ser 
            20                  25                  30          


Val Lys Asp Trp Arg Leu Cys Leu Leu Asp Gln Phe Asp Ala Cys Ala 
        35                  40                  45              


Arg Ser Gly Leu Ser Glu Pro Arg Ser Leu Thr Leu Arg Val Pro Ser 
    50                  55                  60                  


Cys Gly Lys Pro Leu Pro Gly Pro Gly Ala Arg Leu Gly Arg Glu Val 
65                  70                  75                  80  


Thr Pro Cys Leu Ser Phe Ala Phe Ala Trp Cys Trp Leu Lys Met Cys 
                85                  90                  95      


Gln Glu Glu Gln Thr Ser Tyr Met Val Val Gln Thr Ser Glu Glu Gly 
            100                 105                 110         


Leu Ala Ala Asp Ala Glu Leu Pro Gly Pro Leu Leu Met Leu Ala Gln 
        115                 120                 125             


Asn Cys Ala Val Met His Asn Leu Leu Gly Pro Ala Cys Ile Phe Leu 
    130                 135                 140                 


Arg Lys Gly Phe Ala Glu Asn Arg Gln Pro Asp Arg Ser Leu Arg Pro 
145                 150                 155                 160 


Glu Glu Ile Glu Glu Leu Arg Glu Ala Phe Arg Glu Phe Asp Lys Asp 
                165                 170                 175     


Lys Asp Gly Tyr Ile Asn Cys Arg Asp Leu Gly Asn Cys Met Arg Thr 
            180                 185                 190         


Met Gly Tyr Met Pro Thr Glu Met Glu Leu Ile Glu Leu Ser Gln Gln 
        195                 200                 205             


Ile Asn Met Asn Leu Gly Gly His Val Asp Phe Asp Asp Phe Val Glu 
    210                 215                 220                 


Leu Met Gly Pro Lys Leu Leu Ala Glu Thr Ala Asp Met Ile Gly Val 
225                 230                 235                 240 


Lys Glu Leu Arg Asp Ala Phe Arg Glu Phe Asp Thr Asn Gly Asp Gly 
                245                 250                 255     


Glu Ile Ser Thr Ser Glu Leu Arg Glu Ala Met Arg Lys Leu Leu Gly 
            260                 265                 270         


His Gln Val Gly His Arg Asp Ile Glu Glu Ile Ile Arg Asp Val Asp 
        275                 280                 285             


Leu Asn Gly Asp Gly Arg Val Asp Phe Glu Glu Phe Val Arg Met Met 
    290                 295                 300                 


Ser Arg 
305     


<210>  1962
<211>  370
<212>  PRT
<213>  Homo Sapiens

<400>  1962

Met Gly Gly Gly Asp Gly Ala Ala Phe Lys Arg Pro Gly Asp Gly Ala 
1               5                   10                  15      


Arg Leu Gln Arg Val Leu Gly Leu Gly Ser Arg Arg Glu Pro Arg Ser 
            20                  25                  30          


Leu Pro Ala Gly Gly Pro Ala Pro Arg Arg Thr Ala Pro Pro Pro Pro 
        35                  40                  45              


Gly His Ala Ser Ala Gly Pro Ala Ala Met Ser Ser His Ile Ala Lys 
    50                  55                  60                  


Ser Glu Ser Lys Thr Ser Leu Leu Lys Ala Ala Ala Ala Ala Ala Ser 
65                  70                  75                  80  


Gly Gly Ser Arg Ala Pro Arg His Gly Pro Ala Arg Asp Pro Gly Leu 
                85                  90                  95      


Pro Ser Arg Arg Leu Pro Gly Ser Cys Pro Ala Thr Pro Gln Ser Ser 
            100                 105                 110         


Gly Asp Pro Ser Ser Arg Arg Pro Leu Cys Arg Pro Ala Pro Arg Glu 
        115                 120                 125             


Glu Gly Ala Arg Gly Ser Gln Arg Val Leu Pro Gln Ala His Cys Arg 
    130                 135                 140                 


Pro Arg Glu Ala Leu Pro Ala Ala Ala Ser Arg Pro Ser Pro Ser Ser 
145                 150                 155                 160 


Pro Leu Pro Pro Ala Arg Gly Arg Asp Gly Glu Glu Arg Gly Leu Ser 
                165                 170                 175     


Pro Ala Leu Gly Leu Arg Gly Ser Leu Arg Ala Arg Gly Arg Gly Asp 
            180                 185                 190         


Ser Val Pro Ala Ala Ala Ser Glu Ala Asp Pro Phe Leu His Arg Leu 
        195                 200                 205             


Arg Pro Met Leu Ser Ser Ala Phe Gly Gln Asp Arg Ser Leu Arg Pro 
    210                 215                 220                 


Glu Glu Ile Glu Glu Leu Arg Glu Ala Phe Arg Glu Phe Asp Lys Asp 
225                 230                 235                 240 


Lys Asp Gly Tyr Ile Asn Cys Arg Asp Leu Gly Asn Cys Met Arg Thr 
                245                 250                 255     


Met Gly Tyr Met Pro Thr Glu Met Glu Leu Ile Glu Leu Ser Gln Gln 
            260                 265                 270         


Ile Asn Met Asn Leu Gly Gly His Val Asp Phe Asp Asp Phe Val Glu 
        275                 280                 285             


Leu Met Gly Pro Lys Leu Leu Ala Glu Thr Ala Asp Met Ile Gly Val 
    290                 295                 300                 


Lys Glu Leu Arg Asp Ala Phe Arg Glu Phe Asp Thr Asn Gly Asp Gly 
305                 310                 315                 320 


Glu Ile Ser Thr Ser Glu Leu Arg Glu Ala Met Arg Lys Leu Leu Gly 
                325                 330                 335     


His Gln Val Gly His Arg Asp Ile Glu Glu Ile Ile Arg Asp Val Asp 
            340                 345                 350         


Leu Asn Gly Asp Gly Arg Val Asp Phe Glu Glu Phe Val Arg Met Met 
        355                 360                 365             


Ser Arg 
    370 


<210>  1963
<211>  167
<212>  PRT
<213>  Homo Sapiens

<400>  1963

Met Gly Asn Cys Val Lys Tyr Pro Leu Arg Asn Leu Ser Arg Lys Asp 
1               5                   10                  15      


Arg Ser Leu Arg Pro Glu Glu Ile Glu Glu Leu Arg Glu Ala Phe Arg 
            20                  25                  30          


Glu Phe Asp Lys Asp Lys Asp Gly Tyr Ile Asn Cys Arg Asp Leu Gly 
        35                  40                  45              


Asn Cys Met Arg Thr Met Gly Tyr Met Pro Thr Glu Met Glu Leu Ile 
    50                  55                  60                  


Glu Leu Ser Gln Gln Ile Asn Met Asn Leu Gly Gly His Val Asp Phe 
65                  70                  75                  80  


Asp Asp Phe Val Glu Leu Met Gly Pro Lys Leu Leu Ala Glu Thr Ala 
                85                  90                  95      


Asp Met Ile Gly Val Lys Glu Leu Arg Asp Ala Phe Arg Glu Phe Asp 
            100                 105                 110         


Thr Asn Gly Asp Gly Glu Ile Ser Thr Ser Glu Leu Arg Glu Ala Met 
        115                 120                 125             


Arg Lys Leu Leu Gly His Gln Val Gly His Arg Asp Ile Glu Glu Ile 
    130                 135                 140                 


Ile Arg Asp Val Asp Leu Asn Gly Asp Gly Arg Val Asp Phe Glu Glu 
145                 150                 155                 160 


Phe Val Arg Met Met Ser Arg 
                165         


<210>  1964
<211>  227
<212>  PRT
<213>  Homo Sapiens

<400>  1964

Met Gly Asn Cys Val Lys Tyr Pro Leu Arg Asn Leu Ser Arg Lys Met 
1               5                   10                  15      


Cys Gln Glu Glu Gln Thr Ser Tyr Met Val Val Gln Thr Ser Glu Glu 
            20                  25                  30          


Gly Leu Ala Ala Asp Ala Glu Leu Pro Gly Pro Leu Leu Met Leu Ala 
        35                  40                  45              


Gln Asn Cys Ala Val Met His Asn Leu Leu Gly Pro Ala Cys Ile Phe 
    50                  55                  60                  


Leu Arg Lys Gly Phe Ala Glu Asn Arg Gln Pro Asp Arg Ser Leu Arg 
65                  70                  75                  80  


Pro Glu Glu Ile Glu Glu Leu Arg Glu Ala Phe Arg Glu Phe Asp Lys 
                85                  90                  95      


Asp Lys Asp Gly Tyr Ile Asn Cys Arg Asp Leu Gly Asn Cys Met Arg 
            100                 105                 110         


Thr Met Gly Tyr Met Pro Thr Glu Met Glu Leu Ile Glu Leu Ser Gln 
        115                 120                 125             


Gln Ile Asn Met Asn Leu Gly Gly His Val Asp Phe Asp Asp Phe Val 
    130                 135                 140                 


Glu Leu Met Gly Pro Lys Leu Leu Ala Glu Thr Ala Asp Met Ile Gly 
145                 150                 155                 160 


Val Lys Glu Leu Arg Asp Ala Phe Arg Glu Phe Asp Thr Asn Gly Asp 
                165                 170                 175     


Gly Glu Ile Ser Thr Ser Glu Leu Arg Glu Ala Met Arg Lys Leu Leu 
            180                 185                 190         


Gly His Gln Val Gly His Arg Asp Ile Glu Glu Ile Ile Arg Asp Val 
        195                 200                 205             


Asp Leu Asn Gly Asp Gly Arg Val Asp Phe Glu Glu Phe Val Arg Met 
    210                 215                 220                 


Met Ser Arg 
225         


<210>  1965
<211>  1091
<212>  PRT
<213>  Homo Sapiens

<400>  1965

Met Ala Ala Gly Cys Leu Leu Ala Leu Thr Leu Thr Leu Phe Gln Ser 
1               5                   10                  15      


Leu Leu Ile Gly Pro Ser Ser Glu Glu Pro Phe Pro Ser Ala Val Thr 
            20                  25                  30          


Ile Lys Ser Trp Val Asp Lys Met Gln Glu Asp Leu Val Thr Leu Ala 
        35                  40                  45              


Lys Thr Ala Ser Gly Val Asn Gln Leu Val Asp Ile Tyr Glu Lys Tyr 
    50                  55                  60                  


Gln Asp Leu Tyr Thr Val Glu Pro Asn Asn Ala Arg Gln Leu Val Glu 
65                  70                  75                  80  


Ile Ala Ala Arg Asp Ile Glu Lys Leu Leu Ser Asn Arg Ser Lys Ala 
                85                  90                  95      


Leu Val Arg Leu Ala Leu Glu Ala Glu Lys Val Gln Ala Ala His Gln 
            100                 105                 110         


Trp Arg Glu Asp Phe Ala Ser Asn Glu Val Val Tyr Tyr Asn Ala Lys 
        115                 120                 125             


Asp Asp Leu Asp Pro Glu Lys Asn Asp Ser Glu Pro Gly Ser Gln Arg 
    130                 135                 140                 


Ile Lys Pro Val Phe Ile Glu Asp Ala Asn Phe Gly Arg Gln Ile Ser 
145                 150                 155                 160 


Tyr Gln His Ala Ala Val His Ile Pro Thr Asp Ile Tyr Glu Gly Ser 
                165                 170                 175     


Thr Ile Val Leu Asn Glu Leu Asn Trp Thr Ser Ala Leu Asp Glu Val 
            180                 185                 190         


Phe Lys Lys Asn Arg Glu Glu Asp Pro Ser Leu Leu Trp Gln Val Phe 
        195                 200                 205             


Gly Ser Ala Thr Gly Leu Ala Arg Tyr Tyr Pro Ala Ser Pro Trp Val 
    210                 215                 220                 


Asp Asn Ser Arg Thr Pro Asn Lys Ile Asp Leu Tyr Asp Val Arg Arg 
225                 230                 235                 240 


Arg Pro Trp Tyr Ile Gln Gly Ala Ala Ser Pro Lys Asp Met Leu Ile 
                245                 250                 255     


Leu Val Asp Val Ser Gly Ser Val Ser Gly Leu Thr Leu Lys Leu Ile 
            260                 265                 270         


Arg Thr Ser Val Ser Glu Met Leu Glu Thr Leu Ser Asp Asp Asp Phe 
        275                 280                 285             


Val Asn Val Ala Ser Phe Asn Ser Asn Ala Gln Asp Val Ser Cys Phe 
    290                 295                 300                 


Gln His Leu Val Gln Ala Asn Val Arg Asn Lys Lys Val Leu Lys Asp 
305                 310                 315                 320 


Ala Val Asn Asn Ile Thr Ala Lys Gly Ile Thr Asp Tyr Lys Lys Gly 
                325                 330                 335     


Phe Ser Phe Ala Phe Glu Gln Leu Leu Asn Tyr Asn Val Ser Arg Ala 
            340                 345                 350         


Asn Cys Asn Lys Ile Ile Met Leu Phe Thr Asp Gly Gly Glu Glu Arg 
        355                 360                 365             


Ala Gln Glu Ile Phe Asn Lys Tyr Asn Lys Asp Lys Lys Val Arg Val 
    370                 375                 380                 


Phe Thr Phe Ser Val Gly Gln His Asn Tyr Asp Arg Gly Pro Ile Gln 
385                 390                 395                 400 


Trp Met Ala Cys Glu Asn Lys Gly Tyr Tyr Tyr Glu Ile Pro Ser Ile 
                405                 410                 415     


Gly Ala Ile Arg Ile Asn Thr Gln Glu Tyr Leu Asp Val Leu Gly Arg 
            420                 425                 430         


Pro Met Val Leu Ala Gly Asp Lys Ala Lys Gln Val Gln Trp Thr Asn 
        435                 440                 445             


Val Tyr Leu Asp Ala Leu Glu Leu Gly Leu Val Ile Thr Gly Thr Leu 
    450                 455                 460                 


Pro Val Phe Asn Ile Thr Gly Gln Phe Glu Asn Lys Thr Asn Leu Lys 
465                 470                 475                 480 


Asn Gln Leu Ile Leu Gly Val Met Gly Val Asp Val Ser Leu Glu Asp 
                485                 490                 495     


Ile Lys Arg Leu Thr Pro Arg Phe Thr Leu Cys Pro Asn Gly Tyr Tyr 
            500                 505                 510         


Phe Ala Ile Asp Pro Asn Gly Tyr Val Leu Leu His Pro Asn Leu Gln 
        515                 520                 525             


Pro Lys Asn Pro Lys Ser Gln Glu Pro Val Thr Leu Asp Phe Leu Asp 
    530                 535                 540                 


Ala Glu Leu Glu Asn Asp Ile Lys Val Glu Ile Arg Asn Lys Met Ile 
545                 550                 555                 560 


Asp Gly Glu Ser Gly Glu Lys Thr Phe Arg Thr Leu Val Lys Ser Gln 
                565                 570                 575     


Asp Glu Arg Tyr Ile Asp Lys Gly Asn Arg Thr Tyr Thr Trp Thr Pro 
            580                 585                 590         


Val Asn Gly Thr Asp Tyr Ser Leu Ala Leu Val Leu Pro Thr Tyr Ser 
        595                 600                 605             


Phe Tyr Tyr Ile Lys Ala Lys Leu Glu Glu Thr Ile Thr Gln Ala Arg 
    610                 615                 620                 


Ser Lys Lys Gly Lys Met Lys Asp Ser Glu Thr Leu Lys Pro Asp Asn 
625                 630                 635                 640 


Phe Glu Glu Ser Gly Tyr Thr Phe Ile Ala Pro Arg Asp Tyr Cys Asn 
                645                 650                 655     


Asp Leu Lys Ile Ser Asp Asn Asn Thr Glu Phe Leu Leu Asn Phe Asn 
            660                 665                 670         


Glu Phe Ile Asp Arg Lys Thr Pro Asn Asn Pro Ser Cys Asn Ala Asp 
        675                 680                 685             


Leu Ile Asn Arg Val Leu Leu Asp Ala Gly Phe Thr Asn Glu Leu Val 
    690                 695                 700                 


Gln Asn Tyr Trp Ser Lys Gln Lys Asn Ile Lys Gly Val Lys Ala Arg 
705                 710                 715                 720 


Phe Val Val Thr Asp Gly Gly Ile Thr Arg Val Tyr Pro Lys Glu Ala 
                725                 730                 735     


Gly Glu Asn Trp Gln Glu Asn Pro Glu Thr Tyr Glu Asp Ser Phe Tyr 
            740                 745                 750         


Lys Arg Ser Leu Asp Asn Asp Asn Tyr Val Phe Thr Ala Pro Tyr Phe 
        755                 760                 765             


Asn Lys Ser Gly Pro Gly Ala Tyr Glu Ser Gly Ile Met Val Ser Lys 
    770                 775                 780                 


Ala Val Glu Ile Tyr Ile Gln Gly Lys Leu Leu Lys Pro Ala Val Val 
785                 790                 795                 800 


Gly Ile Lys Ile Asp Val Asn Ser Trp Ile Glu Asn Phe Thr Lys Thr 
                805                 810                 815     


Ser Ile Arg Asp Pro Cys Ala Gly Pro Val Cys Asp Cys Lys Arg Asn 
            820                 825                 830         


Ser Asp Val Met Asp Cys Val Ile Leu Asp Asp Gly Gly Phe Leu Leu 
        835                 840                 845             


Met Ala Asn His Asp Asp Tyr Thr Asn Gln Ile Gly Arg Phe Phe Gly 
    850                 855                 860                 


Glu Ile Asp Pro Ser Leu Met Arg His Leu Val Asn Ile Ser Val Tyr 
865                 870                 875                 880 


Ala Phe Asn Lys Ser Tyr Asp Tyr Gln Ser Val Cys Glu Pro Gly Ala 
                885                 890                 895     


Ala Pro Lys Gln Gly Ala Gly His Arg Ser Ala Tyr Val Pro Ser Val 
            900                 905                 910         


Ala Asp Ile Leu Gln Ile Gly Trp Trp Ala Thr Ala Ala Ala Trp Ser 
        915                 920                 925             


Ile Leu Gln Gln Phe Leu Leu Ser Leu Thr Phe Pro Arg Leu Leu Glu 
    930                 935                 940                 


Ala Val Glu Met Glu Asp Asp Asp Phe Thr Ala Ser Leu Ser Lys Gln 
945                 950                 955                 960 


Ser Cys Ile Thr Glu Gln Thr Gln Tyr Phe Phe Asp Asn Asp Ser Lys 
                965                 970                 975     


Ser Phe Ser Gly Val Leu Asp Cys Gly Asn Cys Ser Arg Ile Phe His 
            980                 985                 990         


Gly Glu Lys Leu Met Asn Thr Asn  Leu Ile Phe Ile Met  Val Glu Ser 
        995                 1000                 1005             


Lys Gly  Thr Cys Pro Cys Asp  Thr Arg Leu Leu Ile  Gln Ala Glu 
    1010                 1015                 1020             


Gln Thr  Ser Asp Gly Pro Asn  Pro Cys Asp Met Val  Lys Gln Pro 
    1025                 1030                 1035             


Arg Tyr  Arg Lys Gly Pro Asp  Val Cys Phe Asp Asn  Asn Val Leu 
    1040                 1045                 1050             


Glu Asp  Tyr Thr Asp Cys Gly  Gly Val Ser Gly Leu  Asn Pro Ser 
    1055                 1060                 1065             


Leu Trp  Tyr Ile Ile Gly Ile  Gln Phe Leu Leu Leu  Trp Leu Val 
    1070                 1075                 1080             


Ser Gly  Ser Thr His Arg Leu  Leu 
    1085                 1090     


<210>  1966
<211>  1103
<212>  PRT
<213>  Homo Sapiens

<400>  1966

Met Ala Ala Gly Cys Leu Leu Ala Leu Thr Leu Thr Leu Phe Gln Ser 
1               5                   10                  15      


Leu Leu Ile Gly Pro Ser Ser Glu Glu Pro Phe Pro Ser Ala Val Thr 
            20                  25                  30          


Ile Lys Ser Trp Val Asp Lys Met Gln Glu Asp Leu Val Thr Leu Ala 
        35                  40                  45              


Lys Thr Ala Ser Gly Val Asn Gln Leu Val Asp Ile Tyr Glu Lys Tyr 
    50                  55                  60                  


Gln Asp Leu Tyr Thr Val Glu Pro Asn Asn Ala Arg Gln Leu Val Glu 
65                  70                  75                  80  


Ile Ala Ala Arg Asp Ile Glu Lys Leu Leu Ser Asn Arg Ser Lys Ala 
                85                  90                  95      


Leu Val Arg Leu Ala Leu Glu Ala Glu Lys Val Gln Ala Ala His Gln 
            100                 105                 110         


Trp Arg Glu Asp Phe Ala Ser Asn Glu Val Val Tyr Tyr Asn Ala Lys 
        115                 120                 125             


Asp Asp Leu Asp Pro Glu Lys Asn Asp Ser Glu Pro Gly Ser Gln Arg 
    130                 135                 140                 


Ile Lys Pro Val Phe Ile Glu Asp Ala Asn Phe Gly Arg Gln Ile Ser 
145                 150                 155                 160 


Tyr Gln His Ala Ala Val His Ile Pro Thr Asp Ile Tyr Glu Gly Ser 
                165                 170                 175     


Thr Ile Val Leu Asn Glu Leu Asn Trp Thr Ser Ala Leu Asp Glu Val 
            180                 185                 190         


Phe Lys Lys Asn Arg Glu Glu Asp Pro Ser Leu Leu Trp Gln Val Phe 
        195                 200                 205             


Gly Ser Ala Thr Gly Leu Ala Arg Tyr Tyr Pro Ala Ser Pro Trp Val 
    210                 215                 220                 


Asp Asn Ser Arg Thr Pro Asn Lys Ile Asp Leu Tyr Asp Val Arg Arg 
225                 230                 235                 240 


Arg Pro Trp Tyr Ile Gln Gly Ala Ala Ser Pro Lys Asp Met Leu Ile 
                245                 250                 255     


Leu Val Asp Val Ser Gly Ser Val Ser Gly Leu Thr Leu Lys Leu Ile 
            260                 265                 270         


Arg Thr Ser Val Ser Glu Met Leu Glu Thr Leu Ser Asp Asp Asp Phe 
        275                 280                 285             


Val Asn Val Ala Ser Phe Asn Ser Asn Ala Gln Asp Val Ser Cys Phe 
    290                 295                 300                 


Gln His Leu Val Gln Ala Asn Val Arg Asn Lys Lys Val Leu Lys Asp 
305                 310                 315                 320 


Ala Val Asn Asn Ile Thr Ala Lys Gly Ile Thr Asp Tyr Lys Lys Gly 
                325                 330                 335     


Phe Ser Phe Ala Phe Glu Gln Leu Leu Asn Tyr Asn Val Ser Arg Ala 
            340                 345                 350         


Asn Cys Asn Lys Ile Ile Met Leu Phe Thr Asp Gly Gly Glu Glu Arg 
        355                 360                 365             


Ala Gln Glu Ile Phe Asn Lys Tyr Asn Lys Asp Lys Lys Val Arg Val 
    370                 375                 380                 


Phe Thr Phe Ser Val Gly Gln His Asn Tyr Asp Arg Gly Pro Ile Gln 
385                 390                 395                 400 


Trp Met Ala Cys Glu Asn Lys Gly Tyr Tyr Tyr Glu Ile Pro Ser Ile 
                405                 410                 415     


Gly Ala Ile Arg Ile Asn Thr Gln Glu Tyr Leu Asp Val Leu Gly Arg 
            420                 425                 430         


Pro Met Val Leu Ala Gly Asp Lys Ala Lys Gln Val Gln Trp Thr Asn 
        435                 440                 445             


Val Tyr Leu Asp Ala Leu Glu Leu Gly Leu Val Ile Thr Gly Thr Leu 
    450                 455                 460                 


Pro Val Phe Asn Ile Thr Gly Gln Phe Glu Asn Lys Thr Asn Leu Lys 
465                 470                 475                 480 


Asn Gln Leu Ile Leu Gly Val Met Gly Val Asp Val Ser Leu Glu Asp 
                485                 490                 495     


Ile Lys Arg Leu Thr Pro Arg Phe Thr Leu Cys Pro Asn Gly Tyr Tyr 
            500                 505                 510         


Phe Ala Ile Asp Pro Asn Gly Tyr Val Leu Leu His Pro Asn Leu Gln 
        515                 520                 525             


Pro Lys Pro Ile Gly Val Gly Ile Pro Thr Ile Asn Leu Arg Lys Arg 
    530                 535                 540                 


Arg Pro Asn Ile Gln Asn Pro Lys Ser Gln Glu Pro Val Thr Leu Asp 
545                 550                 555                 560 


Phe Leu Asp Ala Glu Leu Glu Asn Asp Ile Lys Val Glu Ile Arg Asn 
                565                 570                 575     


Lys Met Ile Asp Gly Glu Ser Gly Glu Lys Thr Phe Arg Thr Leu Val 
            580                 585                 590         


Lys Ser Gln Asp Glu Arg Tyr Ile Asp Lys Gly Asn Arg Thr Tyr Thr 
        595                 600                 605             


Trp Thr Pro Val Asn Gly Thr Asp Tyr Ser Leu Ala Leu Val Leu Pro 
    610                 615                 620                 


Thr Tyr Ser Phe Tyr Tyr Ile Lys Ala Lys Leu Glu Glu Thr Ile Thr 
625                 630                 635                 640 


Gln Ala Arg Tyr Ser Glu Thr Leu Lys Pro Asp Asn Phe Glu Glu Ser 
                645                 650                 655     


Gly Tyr Thr Phe Ile Ala Pro Arg Asp Tyr Cys Asn Asp Leu Lys Ile 
            660                 665                 670         


Ser Asp Asn Asn Thr Glu Phe Leu Leu Asn Phe Asn Glu Phe Ile Asp 
        675                 680                 685             


Arg Lys Thr Pro Asn Asn Pro Ser Cys Asn Ala Asp Leu Ile Asn Arg 
    690                 695                 700                 


Val Leu Leu Asp Ala Gly Phe Thr Asn Glu Leu Val Gln Asn Tyr Trp 
705                 710                 715                 720 


Ser Lys Gln Lys Asn Ile Lys Gly Val Lys Ala Arg Phe Val Val Thr 
                725                 730                 735     


Asp Gly Gly Ile Thr Arg Val Tyr Pro Lys Glu Ala Gly Glu Asn Trp 
            740                 745                 750         


Gln Glu Asn Pro Glu Thr Tyr Glu Asp Ser Phe Tyr Lys Arg Ser Leu 
        755                 760                 765             


Asp Asn Asp Asn Tyr Val Phe Thr Ala Pro Tyr Phe Asn Lys Ser Gly 
    770                 775                 780                 


Pro Gly Ala Tyr Glu Ser Gly Ile Met Val Ser Lys Ala Val Glu Ile 
785                 790                 795                 800 


Tyr Ile Gln Gly Lys Leu Leu Lys Pro Ala Val Val Gly Ile Lys Ile 
                805                 810                 815     


Asp Val Asn Ser Trp Ile Glu Asn Phe Thr Lys Thr Ser Ile Arg Asp 
            820                 825                 830         


Pro Cys Ala Gly Pro Val Cys Asp Cys Lys Arg Asn Ser Asp Val Met 
        835                 840                 845             


Asp Cys Val Ile Leu Asp Asp Gly Gly Phe Leu Leu Met Ala Asn His 
    850                 855                 860                 


Asp Asp Tyr Thr Asn Gln Ile Gly Arg Phe Phe Gly Glu Ile Asp Pro 
865                 870                 875                 880 


Ser Leu Met Arg His Leu Val Asn Ile Ser Val Tyr Ala Phe Asn Lys 
                885                 890                 895     


Ser Tyr Asp Tyr Gln Ser Val Cys Glu Pro Gly Ala Ala Pro Lys Gln 
            900                 905                 910         


Gly Ala Gly His Arg Ser Ala Tyr Val Pro Ser Val Ala Asp Ile Leu 
        915                 920                 925             


Gln Ile Gly Trp Trp Ala Thr Ala Ala Ala Trp Ser Ile Leu Gln Gln 
    930                 935                 940                 


Phe Leu Leu Ser Leu Thr Phe Pro Arg Leu Leu Glu Ala Val Glu Met 
945                 950                 955                 960 


Glu Asp Asp Asp Phe Thr Ala Ser Leu Ser Lys Gln Ser Cys Ile Thr 
                965                 970                 975     


Glu Gln Thr Gln Tyr Phe Phe Asp Asn Asp Ser Lys Ser Phe Ser Gly 
            980                 985                 990         


Val Leu Asp Cys Gly Asn Cys Ser  Arg Ile Phe His Gly  Glu Lys Leu 
        995                 1000                 1005             


Met Asn  Thr Asn Leu Ile Phe  Ile Met Val Glu Ser  Lys Gly Thr 
    1010                 1015                 1020             


Cys Pro  Cys Asp Thr Arg Leu  Leu Ile Gln Ala Glu  Gln Thr Ser 
    1025                 1030                 1035             


Asp Gly  Pro Asn Pro Cys Asp  Met Val Lys Gln Pro  Arg Tyr Arg 
    1040                 1045                 1050             


Lys Gly  Pro Asp Val Cys Phe  Asp Asn Asn Val Leu  Glu Asp Tyr 
    1055                 1060                 1065             


Thr Asp  Cys Gly Gly Val Ser  Gly Leu Asn Pro Ser  Leu Trp Tyr 
    1070                 1075                 1080             


Ile Ile  Gly Ile Gln Phe Leu  Leu Leu Trp Leu Val  Ser Gly Ser 
    1085                 1090                 1095             


Thr His  Arg Leu Leu 
    1100             


<210>  1967
<211>  309
<212>  PRT
<213>  Homo Sapiens

<400>  1967

Met Ala Ala Gly Cys Leu Leu Ala Leu Thr Leu Thr Leu Phe Gln Ser 
1               5                   10                  15      


Leu Leu Ile Gly Pro Ser Ser Glu Glu Pro Phe Pro Ser Ala Val Thr 
            20                  25                  30          


Ile Lys Ser Trp Val Asp Lys Met Gln Glu Asp Leu Val Thr Leu Ala 
        35                  40                  45              


Lys Thr Ala Ser Gly Val Asn Gln Leu Val Asp Ile Tyr Glu Lys Tyr 
    50                  55                  60                  


Gln Asp Leu Tyr Thr Val Glu Pro Asn Asn Ala Arg Gln Leu Val Glu 
65                  70                  75                  80  


Ile Ala Ala Arg Asp Ile Glu Lys Leu Leu Ser Asn Arg Ser Lys Ala 
                85                  90                  95      


Leu Val Arg Leu Ala Leu Glu Ala Glu Lys Val Gln Ala Ala His Gln 
            100                 105                 110         


Trp Arg Glu Asp Phe Ala Ser Asn Glu Val Val Tyr Tyr Asn Ala Lys 
        115                 120                 125             


Asp Asp Leu Asp Pro Glu Lys Asn Asp Ser Glu Pro Gly Ser Gln Arg 
    130                 135                 140                 


Ile Lys Pro Val Phe Ile Glu Asp Ala Asn Phe Gly Arg Gln Ile Ser 
145                 150                 155                 160 


Tyr Gln His Ala Ala Val His Ile Pro Thr Asp Ile Tyr Glu Gly Ser 
                165                 170                 175     


Thr Ile Val Leu Asn Glu Leu Asn Trp Thr Ser Ala Leu Asp Glu Val 
            180                 185                 190         


Phe Lys Lys Asn Arg Glu Glu Asp Pro Ser Leu Leu Trp Gln Val Phe 
        195                 200                 205             


Gly Ser Ala Thr Gly Leu Ala Arg Tyr Tyr Pro Ala Ser Pro Trp Val 
    210                 215                 220                 


Asp Asn Ser Arg Thr Pro Asn Lys Ile Asp Leu Tyr Asp Val Arg Arg 
225                 230                 235                 240 


Arg Pro Trp Tyr Ile Gln Gly Ala Ala Ser Pro Lys Asp Met Leu Ile 
                245                 250                 255     


Leu Val Asp Val Ser Gly Ser Val Ser Gly Leu Thr Leu Lys Leu Ile 
            260                 265                 270         


Arg Thr Ser Val Ser Glu Met Leu Glu Thr Leu Ser Asp Asp Asp Phe 
        275                 280                 285             


Val Asn Val Ala Ser Asp Ser Lys Glu Ile Ser Pro Ser Pro Glu Glu 
    290                 295                 300                 


Ile Phe Asn Ala Glu 
305                 


<210>  1968
<211>  280
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1968

Xaa Lys Arg Leu Thr Pro Arg Phe Thr Leu Cys Pro Asn Gly Tyr Tyr 
1               5                   10                  15      


Phe Ala Ile Asp Pro Asn Gly Tyr Val Leu Leu His Pro Asn Leu Gln 
            20                  25                  30          


Pro Lys Pro Ile Gly Val Gly Ile Pro Thr Ile Asn Leu Arg Lys Arg 
        35                  40                  45              


Arg Pro Asn Ile Gln Glu Pro Val Thr Leu Asp Phe Leu Asp Ala Glu 
    50                  55                  60                  


Leu Glu Asn Asp Ile Lys Val Glu Ile Arg Asn Lys Met Ile Asp Gly 
65                  70                  75                  80  


Glu Ser Gly Glu Lys Thr Phe Arg Thr Leu Val Lys Ser Gln Asp Glu 
                85                  90                  95      


Arg Tyr Ile Asp Lys Gly Asn Arg Thr Tyr Thr Trp Thr Pro Val Asn 
            100                 105                 110         


Gly Thr Asp Tyr Ser Leu Ala Leu Val Leu Pro Thr Tyr Ser Phe Tyr 
        115                 120                 125             


Tyr Ile Lys Ala Lys Leu Glu Glu Thr Ile Thr Gln Ala Arg Tyr Ser 
    130                 135                 140                 


Glu Thr Leu Lys Pro Asp Asn Phe Glu Glu Ser Gly Tyr Thr Phe Ile 
145                 150                 155                 160 


Ala Pro Arg Asp Tyr Cys Asn Asp Leu Lys Ile Ser Asp Asn Asn Thr 
                165                 170                 175     


Glu Phe Leu Leu Asn Phe Asn Glu Phe Ile Asp Arg Lys Thr Pro Asn 
            180                 185                 190         


Asn Pro Ser Cys Asn Ala Asp Leu Ile Asn Arg Val Leu Leu Asp Ala 
        195                 200                 205             


Gly Phe Thr Asn Glu Leu Val Gln Asn Tyr Trp Ser Lys Gln Lys Asn 
    210                 215                 220                 


Ile Lys Gly Val Lys Ala Arg Phe Val Val Thr Asp Gly Gly Ile Thr 
225                 230                 235                 240 


Arg Val Tyr Pro Lys Glu Ala Gly Glu Asn Trp Gln Glu Asn Pro Glu 
                245                 250                 255     


Thr Tyr Glu Asp Ser Phe Tyr Lys Arg Ser Leu Asp Asn Asp Asn Tyr 
            260                 265                 270         


Val Phe Thr Ala Pro Tyr Phe Asn 
        275                 280 


<210>  1969
<211>  1073
<212>  PRT
<213>  Homo Sapiens

<400>  1969

Met Ala Val Ala Leu Gly Thr Arg Arg Arg Asp Arg Val Lys Leu Trp 
1               5                   10                  15      


Ala Asp Thr Phe Gly Gly Asp Leu Tyr Asn Thr Val Thr Lys Tyr Ser 
            20                  25                  30          


Gly Ser Leu Leu Leu Gln Lys Lys Tyr Lys Asp Val Glu Ser Ser Leu 
        35                  40                  45              


Lys Ile Glu Glu Val Asp Gly Leu Glu Leu Val Arg Lys Phe Ser Glu 
    50                  55                  60                  


Asp Met Glu Asn Met Leu Arg Arg Lys Val Glu Ala Val Gln Asn Leu 
65                  70                  75                  80  


Val Glu Ala Ala Glu Glu Ala Asp Leu Asn His Glu Phe Asn Glu Ser 
                85                  90                  95      


Leu Val Phe Asp Tyr Tyr Asn Ser Val Leu Ile Asn Glu Arg Asp Glu 
            100                 105                 110         


Lys Gly Asn Phe Val Glu Leu Gly Ala Glu Phe Leu Leu Glu Ser Asn 
        115                 120                 125             


Ala His Phe Ser Asn Leu Pro Val Asn Thr Ser Ile Ser Ser Val Gln 
    130                 135                 140                 


Leu Pro Thr Asn Val Tyr Asn Lys Asp Pro Asp Ile Leu Asn Gly Val 
145                 150                 155                 160 


Tyr Met Ser Glu Ala Leu Asn Ala Val Phe Val Glu Asn Phe Gln Arg 
                165                 170                 175     


Asp Pro Thr Leu Thr Trp Gln Tyr Phe Gly Ser Ala Thr Gly Phe Phe 
            180                 185                 190         


Arg Ile Tyr Pro Gly Ile Lys Trp Thr Pro Asp Glu Asn Gly Val Ile 
        195                 200                 205             


Thr Phe Asp Cys Arg Asn Arg Gly Trp Tyr Ile Gln Ala Ala Thr Ser 
    210                 215                 220                 


Pro Lys Asp Ile Val Ile Leu Val Asp Val Ser Gly Ser Met Lys Gly 
225                 230                 235                 240 


Leu Arg Met Thr Ile Ala Lys His Thr Ile Thr Thr Ile Leu Asp Thr 
                245                 250                 255     


Leu Gly Glu Asn Asp Phe Ile Asn Ile Ile Ala Tyr Asn Asp Tyr Val 
            260                 265                 270         


His Tyr Ile Glu Pro Cys Phe Lys Gly Ile Leu Val Gln Ala Asp Arg 
        275                 280                 285             


Asp Asn Arg Glu His Phe Lys Leu Leu Val Glu Glu Leu Met Val Lys 
    290                 295                 300                 


Gly Val Gly Val Val Asp Gln Ala Leu Arg Glu Ala Phe Gln Ile Leu 
305                 310                 315                 320 


Lys Gln Phe Gln Glu Ala Lys Gln Gly Ser Leu Cys Asn Gln Ala Ile 
                325                 330                 335     


Met Leu Ile Ser Asp Gly Ala Val Glu Asp Tyr Glu Pro Val Phe Glu 
            340                 345                 350         


Lys Tyr Asn Trp Pro Asp Cys Lys Val Arg Val Phe Thr Tyr Leu Ile 
        355                 360                 365             


Gly Arg Glu Val Ser Phe Ala Asp Arg Met Lys Trp Ile Ala Cys Asn 
    370                 375                 380                 


Asn Lys Gly Tyr Tyr Thr Gln Ile Ser Thr Leu Ala Asp Thr Gln Glu 
385                 390                 395                 400 


Asn Val Met Glu Tyr Leu His Val Leu Ser Arg Pro Met Val Ile Asn 
                405                 410                 415     


His Asp His Asp Ile Ile Trp Thr Glu Ala Tyr Met Asp Ser Lys Leu 
            420                 425                 430         


Leu Ser Ser Gln Ala Gln Ser Leu Thr Leu Leu Thr Thr Val Ala Met 
        435                 440                 445             


Pro Val Phe Ser Lys Lys Asn Glu Thr Arg Ser His Gly Ile Leu Leu 
    450                 455                 460                 


Gly Val Val Gly Ser Asp Val Ala Leu Arg Glu Leu Met Lys Leu Ala 
465                 470                 475                 480 


Pro Arg Tyr Lys Leu Gly Val His Gly Tyr Ala Phe Leu Asn Thr Asn 
                485                 490                 495     


Asn Gly Tyr Ile Leu Ser His Pro Asp Leu Arg Pro Leu Tyr Arg Glu 
            500                 505                 510         


Gly Lys Lys Leu Lys Pro Lys Pro Asn Tyr Asn Ser Val Asp Leu Ser 
        515                 520                 525             


Glu Val Glu Trp Glu Asp Gln Ala Glu Ser Leu Arg Thr Ala Met Ile 
    530                 535                 540                 


Asn Arg Glu Thr Gly Thr Leu Ser Met Asp Val Lys Val Pro Met Asp 
545                 550                 555                 560 


Lys Gly Lys Arg Val Leu Phe Leu Thr Asn Asp Tyr Phe Phe Thr Asp 
                565                 570                 575     


Ile Ser Asp Thr Pro Phe Ser Leu Gly Val Val Leu Ser Arg Gly His 
            580                 585                 590         


Gly Glu Tyr Ile Leu Leu Gly Asn Thr Ser Val Glu Glu Gly Leu His 
        595                 600                 605             


Asp Leu Leu His Pro Asp Leu Ala Leu Ala Gly Asp Trp Ile Tyr Cys 
    610                 615                 620                 


Ile Thr Asp Ile Asp Pro Asp His Arg Lys Leu Ser Gln Leu Glu Ala 
625                 630                 635                 640 


Met Ile Arg Phe Leu Thr Arg Lys Asp Pro Asp Leu Glu Cys Asp Glu 
                645                 650                 655     


Glu Leu Val Arg Glu Val Leu Phe Asp Ala Val Val Thr Ala Pro Met 
            660                 665                 670         


Glu Ala Tyr Trp Thr Ala Leu Ala Leu Asn Met Ser Glu Glu Ser Glu 
        675                 680                 685             


His Val Val Asp Met Ala Phe Leu Gly Thr Arg Ala Gly Leu Leu Arg 
    690                 695                 700                 


Ser Ser Leu Phe Val Gly Ser Glu Lys Val Ser Asp Arg Lys Phe Leu 
705                 710                 715                 720 


Thr Pro Glu Asp Glu Ala Ser Val Phe Thr Leu Asp Arg Phe Pro Leu 
                725                 730                 735     


Trp Tyr Arg Gln Ala Ser Glu His Pro Ala Gly Ser Phe Val Phe Asn 
            740                 745                 750         


Leu Arg Trp Ala Glu Gly Pro Glu Ser Ala Gly Glu Pro Met Val Val 
        755                 760                 765             


Thr Ala Ser Thr Ala Val Ala Val Thr Val Asp Lys Arg Thr Ala Ile 
    770                 775                 780                 


Ala Ala Ala Ala Gly Val Gln Met Lys Leu Glu Phe Leu Gln Arg Lys 
785                 790                 795                 800 


Phe Trp Ala Ala Thr Arg Gln Cys Ser Thr Val Asp Gly Pro Cys Thr 
                805                 810                 815     


Gln Ser Cys Glu Asp Ser Asp Leu Asp Cys Phe Val Ile Asp Asn Asn 
            820                 825                 830         


Gly Phe Ile Leu Ile Ser Lys Arg Ser Arg Glu Thr Gly Arg Phe Leu 
        835                 840                 845             


Gly Glu Val Asp Gly Ala Val Leu Thr Gln Leu Leu Ser Met Gly Val 
    850                 855                 860                 


Phe Ser Gln Val Thr Met Tyr Asp Tyr Gln Ala Met Cys Lys Pro Ser 
865                 870                 875                 880 


Ser His His His Ser Ala Ala Gln Pro Leu Val Ser Pro Ile Ser Ala 
                885                 890                 895     


Phe Leu Thr Ala Thr Arg Trp Leu Leu Gln Glu Leu Val Leu Phe Leu 
            900                 905                 910         


Leu Glu Trp Ser Val Trp Gly Ser Trp Tyr Asp Arg Gly Ala Glu Ala 
        915                 920                 925             


Lys Ser Val Phe His His Ser His Lys His Lys Lys Gln Asp Pro Leu 
    930                 935                 940                 


Gln Pro Cys Asp Thr Glu Tyr Pro Val Phe Val Tyr Gln Pro Ala Ile 
945                 950                 955                 960 


Arg Glu Ala Asn Gly Ile Val Glu Cys Gly Pro Cys Gln Lys Val Phe 
                965                 970                 975     


Val Val Gln Gln Ile Pro Asn Ser Asn Leu Leu Leu Leu Val Thr Asp 
            980                 985                 990         


Pro Thr Cys Asp Cys Ser Ile Phe  Pro Pro Val Leu Gln  Glu Ala Thr 
        995                 1000                 1005             


Glu Val  Lys Tyr Asn Ala Ser  Val Lys Cys Asp Arg  Met Arg Ser 
    1010                 1015                 1020             


Gln Lys  Leu Arg Arg Arg Pro  Asp Ser Cys His Ala  Phe His Pro 
    1025                 1030                 1035             


Glu Glu  Asn Ala Gln Asp Cys  Gly Gly Ala Ser Asp  Thr Ser Ala 
    1040                 1045                 1050             


Ser Pro  Pro Leu Leu Leu Leu  Pro Val Cys Ala Trp  Gly Leu Leu 
    1055                 1060                 1065             


Pro Gln  Leu Leu Arg 
    1070             


<210>  1970
<211>  1090
<212>  PRT
<213>  Homo Sapiens

<400>  1970

Met Ala Val Ala Leu Gly Thr Arg Arg Arg Asp Arg Val Lys Leu Trp 
1               5                   10                  15      


Ala Asp Thr Phe Gly Gly Asp Leu Tyr Asn Thr Val Thr Lys Tyr Ser 
            20                  25                  30          


Gly Ser Leu Leu Leu Gln Lys Lys Tyr Lys Asp Val Glu Ser Ser Leu 
        35                  40                  45              


Lys Ile Glu Glu Val Asp Gly Leu Glu Leu Val Arg Lys Phe Ser Glu 
    50                  55                  60                  


Asp Met Glu Asn Met Leu Arg Arg Lys Val Glu Ala Val Gln Asn Leu 
65                  70                  75                  80  


Val Glu Ala Ala Glu Glu Ala Asp Leu Asn His Glu Phe Asn Glu Ser 
                85                  90                  95      


Leu Val Phe Asp Tyr Tyr Asn Ser Val Leu Ile Asn Glu Arg Asp Glu 
            100                 105                 110         


Lys Gly Asn Phe Val Glu Leu Gly Ala Glu Phe Leu Leu Glu Ser Asn 
        115                 120                 125             


Ala His Phe Ser Asn Leu Pro Val Asn Thr Ser Ile Ser Ser Val Gln 
    130                 135                 140                 


Leu Pro Thr Asn Val Tyr Asn Lys Asp Pro Asp Ile Leu Asn Gly Val 
145                 150                 155                 160 


Tyr Met Ser Glu Ala Leu Asn Ala Val Phe Val Glu Asn Phe Gln Arg 
                165                 170                 175     


Asp Pro Thr Leu Thr Trp Gln Tyr Phe Gly Ser Ala Thr Gly Phe Phe 
            180                 185                 190         


Arg Ile Tyr Pro Gly Ile Lys Trp Thr Pro Asp Glu Asn Gly Val Ile 
        195                 200                 205             


Thr Phe Asp Cys Arg Asn Arg Gly Trp Tyr Ile Gln Ala Ala Thr Ser 
    210                 215                 220                 


Pro Lys Asp Ile Val Ile Leu Val Asp Val Ser Gly Ser Met Lys Gly 
225                 230                 235                 240 


Leu Arg Met Thr Ile Ala Lys His Thr Ile Thr Thr Ile Leu Asp Thr 
                245                 250                 255     


Leu Gly Glu Asn Asp Phe Ile Asn Ile Ile Ala Tyr Asn Asp Tyr Val 
            260                 265                 270         


His Tyr Ile Glu Pro Cys Phe Lys Gly Ile Leu Val Gln Ala Asp Arg 
        275                 280                 285             


Asp Asn Arg Glu His Phe Lys Leu Leu Val Glu Glu Leu Met Val Lys 
    290                 295                 300                 


Gly Val Gly Val Val Asp Gln Ala Leu Arg Glu Ala Phe Gln Ile Leu 
305                 310                 315                 320 


Lys Gln Phe Gln Glu Ala Lys Gln Gly Ser Leu Cys Asn Gln Ala Ile 
                325                 330                 335     


Met Leu Ile Ser Asp Gly Ala Val Glu Asp Tyr Glu Pro Val Phe Glu 
            340                 345                 350         


Lys Tyr Asn Trp Pro Asp Cys Lys Val Arg Val Phe Thr Tyr Leu Ile 
        355                 360                 365             


Gly Arg Glu Val Ser Phe Ala Asp Arg Met Lys Trp Ile Ala Cys Asn 
    370                 375                 380                 


Asn Lys Gly Tyr Tyr Thr Gln Ile Ser Thr Leu Ala Asp Thr Gln Glu 
385                 390                 395                 400 


Asn Val Met Glu Tyr Leu His Val Leu Ser Arg Pro Met Val Ile Asn 
                405                 410                 415     


His Asp His Asp Ile Ile Trp Thr Glu Ala Tyr Met Asp Ser Lys Leu 
            420                 425                 430         


Leu Ser Ser Gln Ala Gln Ser Leu Thr Leu Leu Thr Thr Val Ala Met 
        435                 440                 445             


Pro Val Phe Ser Lys Lys Asn Glu Thr Arg Ser His Gly Ile Leu Leu 
    450                 455                 460                 


Gly Val Val Gly Ser Asp Val Ala Leu Arg Glu Leu Met Lys Leu Ala 
465                 470                 475                 480 


Pro Arg Tyr Lys Leu Gly Val His Gly Tyr Ala Phe Leu Asn Thr Asn 
                485                 490                 495     


Asn Gly Tyr Ile Leu Ser His Pro Asp Leu Arg Pro Leu Tyr Arg Glu 
            500                 505                 510         


Gly Lys Lys Leu Lys Pro Lys Pro Asn Tyr Asn Ser Val Asp Leu Ser 
        515                 520                 525             


Glu Val Glu Trp Glu Asp Gln Ala Glu Ser Leu Arg Thr Ala Met Ile 
    530                 535                 540                 


Asn Arg Glu Thr Gly Thr Leu Ser Met Asp Val Lys Val Pro Met Asp 
545                 550                 555                 560 


Lys Gly Lys Arg Val Leu Phe Leu Thr Asn Asp Tyr Phe Phe Thr Asp 
                565                 570                 575     


Ile Ser Asp Thr Pro Phe Ser Leu Gly Val Val Leu Ser Arg Gly His 
            580                 585                 590         


Gly Glu Tyr Ile Leu Leu Gly Asn Thr Ser Val Glu Glu Gly Leu His 
        595                 600                 605             


Asp Leu Leu His Pro Asp Leu Ala Leu Ala Gly Asp Trp Ile Tyr Cys 
    610                 615                 620                 


Ile Thr Asp Ile Asp Pro Asp His Arg Lys Leu Ser Gln Leu Glu Ala 
625                 630                 635                 640 


Met Ile Arg Phe Leu Thr Arg Lys Asp Pro Asp Leu Glu Cys Asp Glu 
                645                 650                 655     


Glu Leu Val Arg Glu Val Leu Phe Asp Ala Val Val Thr Ala Pro Met 
            660                 665                 670         


Glu Ala Tyr Trp Thr Ala Leu Ala Leu Asn Met Ser Glu Glu Ser Glu 
        675                 680                 685             


His Val Val Asp Met Ala Phe Leu Gly Thr Arg Ala Gly Leu Leu Arg 
    690                 695                 700                 


Ser Ser Leu Phe Val Gly Ser Glu Lys Val Ser Asp Arg Lys Phe Leu 
705                 710                 715                 720 


Thr Pro Glu Asp Glu Ala Ser Val Phe Thr Leu Asp Arg Phe Pro Leu 
                725                 730                 735     


Trp Tyr Arg Gln Ala Ser Glu His Pro Ala Gly Ser Phe Val Phe Asn 
            740                 745                 750         


Leu Arg Trp Ala Glu Gly Pro Glu Ser Ala Gly Glu Pro Met Val Val 
        755                 760                 765             


Thr Ala Ser Thr Ala Val Ala Val Thr Val Asp Lys Arg Thr Ala Ile 
    770                 775                 780                 


Ala Ala Ala Ala Gly Val Gln Met Lys Leu Glu Phe Leu Gln Arg Lys 
785                 790                 795                 800 


Phe Trp Ala Ala Thr Arg Gln Cys Ser Thr Val Asp Gly Pro Cys Thr 
                805                 810                 815     


Gln Ser Cys Glu Asp Ser Asp Leu Asp Cys Phe Val Ile Asp Asn Asn 
            820                 825                 830         


Gly Phe Ile Leu Ile Ser Lys Arg Ser Arg Glu Thr Gly Arg Phe Leu 
        835                 840                 845             


Gly Glu Val Asp Gly Ala Val Leu Thr Gln Leu Leu Ser Met Gly Val 
    850                 855                 860                 


Phe Ser Gln Val Thr Met Tyr Asp Tyr Gln Ala Met Cys Lys Pro Ser 
865                 870                 875                 880 


Ser His His His Ser Ala Ala Gln Pro Leu Val Ser Pro Ile Ser Ala 
                885                 890                 895     


Phe Leu Thr Ala Thr Arg Trp Leu Leu Gln Glu Leu Val Leu Phe Leu 
            900                 905                 910         


Leu Glu Trp Ser Val Trp Gly Ser Trp Tyr Asp Arg Gly Ala Glu Ala 
        915                 920                 925             


Lys Ser Val Phe His His Ser His Lys His Lys Lys Gln Asp Pro Leu 
    930                 935                 940                 


Gln Pro Cys Asp Thr Glu Tyr Pro Val Phe Val Tyr Gln Pro Ala Ile 
945                 950                 955                 960 


Arg Glu Ala Asn Gly Ile Val Glu Cys Gly Pro Cys Gln Lys Val Phe 
                965                 970                 975     


Val Val Gln Gln Ile Pro Asn Ser Asn Leu Leu Leu Leu Val Thr Asp 
            980                 985                 990         


Pro Thr Cys Asp Cys Ser Ile Phe  Pro Pro Val Leu Gln  Glu Ala Thr 
        995                 1000                 1005             


Glu Val  Lys Tyr Asn Ala Ser  Val Lys Cys Asp Arg  Met Arg Ser 
    1010                 1015                 1020             


Gln Lys  Leu Arg Arg Arg Pro  Asp Ser Cys His Ala  Phe His Pro 
    1025                 1030                 1035             


Glu Val  Arg Val Glu Ala Asp  Arg Gly Trp Ala Gly  Phe Ser Ser 
    1040                 1045                 1050             


Pro Asn  Pro Leu Cys Leu Gly  Leu Cys Pro Cys Arg  Gln Glu His 
    1055                 1060                 1065             


Ile Gly  Met Pro Met Asn Thr  Pro Val Pro Val Leu  Leu Gly Gly 
    1070                 1075                 1080             


Asn Ile  Arg Val Tyr Ala Leu  
    1085                 1090 


<210>  1971
<211>  56
<212>  PRT
<213>  Homo Sapiens

<400>  1971

Met Lys Leu Glu Phe Leu Gln Arg Lys Phe Trp Ala Ala Thr Arg Gln 
1               5                   10                  15      


Cys Ser Thr Val Asp Gly Pro Cys Thr Gln Ser Cys Glu Asp Ser Asp 
            20                  25                  30          


Leu Asp Cys Phe Val Ile Asp Asn Asn Gly Phe Ile Leu Ile Ser Lys 
        35                  40                  45              


Arg Ser Arg Glu Ser Asp Tyr Val 
    50                  55      


<210>  1972
<211>  56
<212>  PRT
<213>  Homo Sapiens

<400>  1972

Met Lys Leu Glu Phe Leu Gln Arg Lys Phe Trp Ala Ala Thr Arg Gln 
1               5                   10                  15      


Cys Ser Thr Val Asp Gly Pro Cys Thr Gln Ser Cys Glu Asp Ser Asp 
            20                  25                  30          


Leu Asp Cys Phe Val Ile Asp Asn Asn Gly Phe Ile Leu Ile Ser Lys 
        35                  40                  45              


Arg Ser Arg Glu Ser Asp Tyr Val 
    50                  55      


<210>  1973
<211>  282
<212>  PRT
<213>  Homo Sapiens

<400>  1973

Met Lys Leu Glu Phe Leu Gln Arg Lys Phe Trp Ala Ala Thr Arg Gln 
1               5                   10                  15      


Cys Ser Thr Val Asp Gly Pro Cys Thr Gln Ser Cys Glu Asp Ser Asp 
            20                  25                  30          


Leu Asp Cys Phe Val Ile Asp Asn Asn Gly Phe Ile Leu Ile Ser Lys 
        35                  40                  45              


Arg Ser Arg Glu Thr Gly Arg Phe Leu Gly Glu Val Asp Gly Ala Val 
    50                  55                  60                  


Leu Thr Gln Leu Leu Ser Met Gly Val Phe Ser Gln Val Thr Met Tyr 
65                  70                  75                  80  


Asp Tyr Gln Ala Met Cys Lys Pro Ser Ser His His His Ser Ala Ala 
                85                  90                  95      


Gln Pro Leu Val Ser Pro Ile Ser Ala Phe Leu Thr Ala Thr Arg Trp 
            100                 105                 110         


Leu Leu Gln Glu Leu Val Leu Phe Leu Leu Glu Trp Ser Val Trp Gly 
        115                 120                 125             


Ser Trp Tyr Asp Arg Gly Ala Glu Ala Lys Ser Val Phe His His Ser 
    130                 135                 140                 


His Lys His Lys Lys Gln Asp Pro Leu Gln Pro Cys Asp Thr Glu Tyr 
145                 150                 155                 160 


Pro Val Phe Val Tyr Gln Pro Ala Ile Arg Glu Ala Asn Gly Ile Val 
                165                 170                 175     


Glu Cys Gly Pro Cys Gln Lys Val Phe Val Val Gln Gln Ile Pro Asn 
            180                 185                 190         


Ser Asn Leu Leu Leu Leu Val Thr Asp Pro Thr Cys Asp Cys Ser Ile 
        195                 200                 205             


Phe Pro Pro Val Leu Gln Glu Ala Thr Glu Val Lys Tyr Asn Ala Ser 
    210                 215                 220                 


Val Lys Cys Asp Arg Met Arg Ser Gln Lys Leu Arg Arg Arg Pro Asp 
225                 230                 235                 240 


Ser Cys His Ala Phe His Pro Glu Glu Asn Ala Gln Asp Cys Gly Gly 
                245                 250                 255     


Ala Ser Asp Thr Ser Ala Ser Pro Pro Leu Leu Leu Leu Pro Val Cys 
            260                 265                 270         


Ala Trp Gly Leu Leu Pro Gln Leu Leu Arg 
        275                 280         


<210>  1974
<211>  41
<212>  PRT
<213>  Homo Sapiens

<400>  1974

Met Lys Leu Glu Phe Leu Gln Arg Lys Phe Trp Ala Ala Thr Arg Gln 
1               5                   10                  15      


Asp Leu Asp Cys Phe Val Ile Asp Asn Asn Gly Phe Ile Leu Ile Ser 
            20                  25                  30          


Lys Arg Ser Arg Glu Ser Asp Tyr Val 
        35                  40      


<210>  1975
<211>  267
<212>  PRT
<213>  Homo Sapiens

<400>  1975

Met Lys Leu Glu Phe Leu Gln Arg Lys Phe Trp Ala Ala Thr Arg Gln 
1               5                   10                  15      


Asp Leu Asp Cys Phe Val Ile Asp Asn Asn Gly Phe Ile Leu Ile Ser 
            20                  25                  30          


Lys Arg Ser Arg Glu Thr Gly Arg Phe Leu Gly Glu Val Asp Gly Ala 
        35                  40                  45              


Val Leu Thr Gln Leu Leu Ser Met Gly Val Phe Ser Gln Val Thr Met 
    50                  55                  60                  


Tyr Asp Tyr Gln Ala Met Cys Lys Pro Ser Ser His His His Ser Ala 
65                  70                  75                  80  


Ala Gln Pro Leu Val Ser Pro Ile Ser Ala Phe Leu Thr Ala Thr Arg 
                85                  90                  95      


Trp Leu Leu Gln Glu Leu Val Leu Phe Leu Leu Glu Trp Ser Val Trp 
            100                 105                 110         


Gly Ser Trp Tyr Asp Arg Gly Ala Glu Ala Lys Ser Val Phe His His 
        115                 120                 125             


Ser His Lys His Lys Lys Gln Asp Pro Leu Gln Pro Cys Asp Thr Glu 
    130                 135                 140                 


Tyr Pro Val Phe Val Tyr Gln Pro Ala Ile Arg Glu Ala Asn Gly Ile 
145                 150                 155                 160 


Val Glu Cys Gly Pro Cys Gln Lys Val Phe Val Val Gln Gln Ile Pro 
                165                 170                 175     


Asn Ser Asn Leu Leu Leu Leu Val Thr Asp Pro Thr Cys Asp Cys Ser 
            180                 185                 190         


Ile Phe Pro Pro Val Leu Gln Glu Ala Thr Glu Val Lys Tyr Asn Ala 
        195                 200                 205             


Ser Val Lys Cys Asp Arg Met Arg Ser Gln Lys Leu Arg Arg Arg Pro 
    210                 215                 220                 


Asp Ser Cys His Ala Phe His Pro Glu Glu Asn Ala Gln Asp Cys Gly 
225                 230                 235                 240 


Gly Ala Ser Asp Thr Ser Ala Ser Pro Pro Leu Leu Leu Leu Pro Val 
                245                 250                 255     


Cys Ala Trp Gly Leu Leu Pro Gln Leu Leu Arg 
            260                 265         


<210>  1976
<211>  1137
<212>  PRT
<213>  Homo Sapiens

<400>  1976

Met Val Cys Gly Cys Ser Ala Leu Leu Pro Leu Pro Asn Pro Arg Pro 
1               5                   10                  15      


Thr Met Pro Ala Thr Pro Asn Phe Leu Ala Asn Pro Ser Ser Ser Ser 
            20                  25                  30          


Arg Trp Ile Pro Leu Gln Pro Met Pro Val Ala Trp Ala Phe Val Gln 
        35                  40                  45              


Lys Thr Ser Ala Leu Leu Trp Leu Leu Leu Leu Gly Thr Ser Leu Ser 
    50                  55                  60                  


Pro Ala Trp Gly Gln Ala Lys Ile Pro Leu Glu Thr Val Lys Leu Trp 
65                  70                  75                  80  


Ala Asp Thr Phe Gly Gly Asp Leu Tyr Asn Thr Val Thr Lys Tyr Ser 
                85                  90                  95      


Gly Ser Leu Leu Leu Gln Lys Lys Tyr Lys Asp Val Glu Ser Ser Leu 
            100                 105                 110         


Lys Ile Glu Glu Val Asp Gly Leu Glu Leu Val Arg Lys Phe Ser Glu 
        115                 120                 125             


Asp Met Glu Asn Met Leu Arg Arg Lys Val Glu Ala Val Gln Asn Leu 
    130                 135                 140                 


Val Glu Ala Ala Glu Glu Ala Asp Leu Asn His Glu Phe Asn Glu Ser 
145                 150                 155                 160 


Leu Val Phe Asp Tyr Tyr Asn Ser Val Leu Ile Asn Glu Arg Asp Glu 
                165                 170                 175     


Lys Gly Asn Phe Val Glu Leu Gly Ala Glu Phe Leu Leu Glu Ser Asn 
            180                 185                 190         


Ala His Phe Ser Asn Leu Pro Val Asn Thr Ser Ile Ser Ser Val Gln 
        195                 200                 205             


Leu Pro Thr Asn Val Tyr Asn Lys Asp Pro Asp Ile Leu Asn Gly Val 
    210                 215                 220                 


Tyr Met Ser Glu Ala Leu Asn Ala Val Phe Val Glu Asn Phe Gln Arg 
225                 230                 235                 240 


Asp Pro Thr Leu Thr Trp Gln Tyr Phe Gly Ser Ala Thr Gly Phe Phe 
                245                 250                 255     


Arg Ile Tyr Pro Gly Ile Lys Trp Thr Pro Asp Glu Asn Gly Val Ile 
            260                 265                 270         


Thr Phe Asp Cys Arg Asn Arg Gly Trp Tyr Ile Gln Ala Ala Thr Ser 
        275                 280                 285             


Pro Lys Asp Ile Val Ile Leu Val Asp Val Ser Gly Ser Met Lys Gly 
    290                 295                 300                 


Leu Arg Met Thr Ile Ala Lys His Thr Ile Thr Thr Ile Leu Asp Thr 
305                 310                 315                 320 


Leu Gly Glu Asn Asp Phe Ile Asn Ile Ile Ala Tyr Asn Asp Tyr Val 
                325                 330                 335     


His Tyr Ile Glu Pro Cys Phe Lys Gly Ile Leu Val Gln Ala Asp Arg 
            340                 345                 350         


Asp Asn Arg Glu His Phe Lys Leu Leu Val Glu Glu Leu Met Val Lys 
        355                 360                 365             


Gly Val Gly Val Val Asp Gln Ala Leu Arg Glu Ala Phe Gln Ile Leu 
    370                 375                 380                 


Lys Gln Phe Gln Glu Ala Lys Gln Gly Ser Leu Cys Asn Gln Ala Ile 
385                 390                 395                 400 


Met Leu Ile Ser Asp Gly Ala Val Glu Asp Tyr Glu Pro Val Phe Glu 
                405                 410                 415     


Lys Tyr Asn Trp Pro Asp Cys Lys Val Arg Val Phe Thr Tyr Leu Ile 
            420                 425                 430         


Gly Arg Glu Val Ser Phe Ala Asp Arg Met Lys Trp Ile Ala Cys Asn 
        435                 440                 445             


Asn Lys Gly Tyr Tyr Thr Gln Ile Ser Thr Leu Ala Asp Thr Gln Glu 
    450                 455                 460                 


Asn Val Met Glu Tyr Leu His Val Leu Ser Arg Pro Met Val Ile Asn 
465                 470                 475                 480 


His Asp His Asp Ile Ile Trp Thr Glu Ala Tyr Met Asp Ser Lys Leu 
                485                 490                 495     


Leu Ser Ser Gln Ala Gln Ser Leu Thr Leu Leu Thr Thr Val Ala Met 
            500                 505                 510         


Pro Val Phe Ser Lys Lys Asn Glu Thr Arg Ser His Gly Ile Leu Leu 
        515                 520                 525             


Gly Val Val Gly Ser Asp Val Ala Leu Arg Glu Leu Met Lys Leu Ala 
    530                 535                 540                 


Pro Arg Tyr Lys Leu Gly Val His Gly Tyr Ala Phe Leu Asn Thr Asn 
545                 550                 555                 560 


Asn Gly Tyr Ile Leu Ser His Pro Asp Leu Arg Pro Leu Tyr Arg Glu 
                565                 570                 575     


Gly Lys Lys Leu Lys Pro Lys Pro Asn Tyr Asn Ser Val Asp Leu Ser 
            580                 585                 590         


Glu Val Glu Trp Glu Asp Gln Ala Glu Ser Leu Arg Thr Ala Met Ile 
        595                 600                 605             


Asn Arg Glu Thr Gly Thr Leu Ser Met Asp Val Lys Val Pro Met Asp 
    610                 615                 620                 


Lys Gly Lys Arg Val Leu Phe Leu Thr Asn Asp Tyr Phe Phe Thr Asp 
625                 630                 635                 640 


Ile Ser Asp Thr Pro Phe Ser Leu Gly Val Val Leu Ser Arg Gly His 
                645                 650                 655     


Gly Glu Tyr Ile Leu Leu Gly Asn Thr Ser Val Glu Glu Gly Leu His 
            660                 665                 670         


Asp Leu Leu His Pro Asp Leu Ala Leu Ala Gly Asp Trp Ile Tyr Cys 
        675                 680                 685             


Ile Thr Asp Ile Asp Pro Asp His Arg Lys Leu Ser Gln Leu Glu Ala 
    690                 695                 700                 


Met Ile Arg Phe Leu Thr Arg Lys Asp Pro Asp Leu Glu Cys Asp Glu 
705                 710                 715                 720 


Glu Leu Val Arg Glu Val Leu Phe Asp Ala Val Val Thr Ala Pro Met 
                725                 730                 735     


Glu Ala Tyr Trp Thr Ala Leu Ala Leu Asn Met Ser Glu Glu Ser Glu 
            740                 745                 750         


His Val Val Asp Met Ala Phe Leu Gly Thr Arg Ala Gly Leu Leu Arg 
        755                 760                 765             


Ser Ser Leu Phe Val Gly Ser Glu Lys Val Ser Asp Arg Lys Phe Leu 
    770                 775                 780                 


Thr Pro Glu Asp Glu Ala Ser Val Phe Thr Leu Asp Arg Phe Pro Leu 
785                 790                 795                 800 


Trp Tyr Arg Gln Ala Ser Glu His Pro Ala Gly Ser Phe Val Phe Asn 
                805                 810                 815     


Leu Arg Trp Ala Glu Gly Pro Glu Ser Ala Gly Glu Pro Met Val Val 
            820                 825                 830         


Thr Ala Ser Thr Ala Val Ala Val Thr Val Asp Lys Arg Thr Ala Ile 
        835                 840                 845             


Ala Ala Ala Ala Gly Val Gln Met Lys Leu Glu Phe Leu Gln Arg Lys 
    850                 855                 860                 


Phe Trp Ala Ala Thr Arg Gln Cys Ser Thr Val Asp Gly Pro Cys Thr 
865                 870                 875                 880 


Gln Ser Cys Glu Asp Ser Asp Leu Asp Cys Phe Val Ile Asp Asn Asn 
                885                 890                 895     


Gly Phe Ile Leu Ile Ser Lys Arg Ser Arg Glu Thr Gly Arg Phe Leu 
            900                 905                 910         


Gly Glu Val Asp Gly Ala Val Leu Thr Gln Leu Leu Ser Met Gly Val 
        915                 920                 925             


Phe Ser Gln Val Thr Met Tyr Asp Tyr Gln Ala Met Cys Lys Pro Ser 
    930                 935                 940                 


Ser His His His Ser Ala Ala Gln Pro Leu Val Ser Pro Ile Ser Ala 
945                 950                 955                 960 


Phe Leu Thr Ala Thr Arg Trp Leu Leu Gln Glu Leu Val Leu Phe Leu 
                965                 970                 975     


Leu Glu Trp Ser Val Trp Gly Ser Trp Tyr Asp Arg Gly Ala Glu Ala 
            980                 985                 990         


Lys Ser Val Phe His His Ser His  Lys His Lys Lys Gln  Asp Pro Leu 
        995                 1000                 1005             


Gln Pro  Cys Asp Thr Glu Tyr  Pro Val Phe Val Tyr  Gln Pro Ala 
    1010                 1015                 1020             


Ile Arg  Glu Ala Asn Gly Ile  Val Glu Cys Gly Pro  Cys Gln Lys 
    1025                 1030                 1035             


Val Phe  Val Val Gln Gln Ile  Pro Asn Ser Asn Leu  Leu Leu Leu 
    1040                 1045                 1050             


Val Thr  Asp Pro Thr Cys Asp  Cys Ser Ile Phe Pro  Pro Val Leu 
    1055                 1060                 1065             


Gln Glu  Ala Thr Glu Val Lys  Tyr Asn Ala Ser Val  Lys Cys Asp 
    1070                 1075                 1080             


Arg Met  Arg Ser Gln Lys Leu  Arg Arg Arg Pro Asp  Ser Cys His 
    1085                 1090                 1095             


Ala Phe  His Pro Glu Glu Asn  Ala Gln Asp Cys Gly  Gly Ala Ser 
    1100                 1105                 1110             


Asp Thr  Ser Ala Ser Pro Pro  Leu Leu Leu Leu Pro  Val Cys Ala 
    1115                 1120                 1125             


Trp Gly  Leu Leu Pro Gln Leu  Leu Arg 
    1130                 1135         


<210>  1977
<211>  601
<212>  PRT
<213>  Homo Sapiens

<400>  1977

Met Val Cys Gly Cys Ser Ala Leu Leu Pro Leu Pro Asn Pro Arg Pro 
1               5                   10                  15      


Thr Met Pro Ala Thr Pro Asn Phe Leu Ala Asn Pro Ser Ser Ser Ser 
            20                  25                  30          


Arg Trp Ile Pro Leu Gln Pro Met Pro Val Ala Trp Ala Phe Val Gln 
        35                  40                  45              


Lys Thr Ser Ala Leu Leu Trp Leu Leu Leu Leu Gly Thr Ser Leu Ser 
    50                  55                  60                  


Pro Ala Trp Gly Gln Ala Lys Ile Pro Leu Glu Thr Val Lys Leu Trp 
65                  70                  75                  80  


Ala Asp Thr Phe Gly Gly Asp Leu Tyr Asn Thr Val Thr Lys Tyr Ser 
                85                  90                  95      


Gly Ser Leu Leu Leu Gln Lys Lys Tyr Lys Asp Val Glu Ser Ser Leu 
            100                 105                 110         


Lys Ile Glu Glu Val Asp Gly Leu Glu Leu Val Arg Lys Phe Ser Glu 
        115                 120                 125             


Asp Met Glu Asn Met Leu Arg Arg Lys Val Glu Ala Val Gln Asn Leu 
    130                 135                 140                 


Val Glu Ala Ala Glu Glu Ala Asp Leu Asn His Glu Phe Asn Glu Ser 
145                 150                 155                 160 


Leu Val Phe Asp Tyr Tyr Asn Ser Val Leu Ile Asn Glu Arg Asp Glu 
                165                 170                 175     


Lys Gly Asn Phe Val Glu Leu Gly Ala Glu Phe Leu Leu Glu Ser Asn 
            180                 185                 190         


Ala His Phe Ser Asn Leu Pro Val Asn Thr Ser Ile Ser Ser Val Gln 
        195                 200                 205             


Leu Pro Thr Asn Val Tyr Asn Lys Asp Pro Asp Ile Leu Asn Gly Val 
    210                 215                 220                 


Tyr Met Ser Glu Ala Leu Asn Ala Val Phe Val Glu Asn Phe Gln Arg 
225                 230                 235                 240 


Asp Pro Thr Leu Thr Trp Gln Tyr Phe Gly Ser Ala Thr Gly Phe Phe 
                245                 250                 255     


Arg Ile Tyr Pro Gly Ile Lys Trp Thr Pro Asp Glu Asn Gly Val Ile 
            260                 265                 270         


Thr Phe Asp Cys Arg Asn Arg Gly Trp Tyr Ile Gln Ala Ala Thr Ser 
        275                 280                 285             


Pro Lys Asp Ile Val Ile Leu Val Asp Val Ser Gly Ser Met Lys Gly 
    290                 295                 300                 


Leu Arg Met Thr Ile Ala Lys His Thr Ile Thr Thr Ile Leu Asp Thr 
305                 310                 315                 320 


Leu Gly Glu Asn Asp Phe Ile Asn Ile Ile Ala Tyr Asn Asp Tyr Val 
                325                 330                 335     


His Tyr Ile Glu Pro Cys Phe Lys Gly Ile Leu Val Gln Ala Asp Arg 
            340                 345                 350         


Asp Asn Arg Glu His Phe Lys Leu Leu Val Glu Glu Leu Met Val Lys 
        355                 360                 365             


Gly Val Gly Val Val Asp Gln Ala Leu Arg Glu Ala Phe Gln Ile Leu 
    370                 375                 380                 


Lys Gln Phe Gln Glu Ala Lys Gln Gly Ser Leu Cys Asn Gln Ala Ile 
385                 390                 395                 400 


Met Leu Ile Ser Asp Gly Ala Val Glu Asp Tyr Glu Pro Val Phe Glu 
                405                 410                 415     


Lys Tyr Asn Trp Pro Asp Cys Lys Val Arg Val Phe Thr Tyr Leu Ile 
            420                 425                 430         


Gly Arg Glu Val Ser Phe Ala Asp Arg Met Lys Trp Ile Ala Cys Asn 
        435                 440                 445             


Asn Lys Gly Tyr Tyr Thr Gln Ile Ser Thr Leu Ala Asp Thr Gln Glu 
    450                 455                 460                 


Asn Val Met Glu Tyr Leu His Val Leu Ser Arg Pro Met Val Ile Asn 
465                 470                 475                 480 


His Asp His Asp Ile Ile Trp Thr Glu Ala Tyr Met Asp Ser Lys Leu 
                485                 490                 495     


Leu Ser Ser Gln Ala Gln Ser Leu Thr Leu Leu Thr Thr Val Ala Met 
            500                 505                 510         


Pro Val Phe Ser Lys Lys Asn Glu Thr Arg Ser His Gly Ile Leu Leu 
        515                 520                 525             


Gly Val Val Gly Ser Asp Val Ala Leu Arg Glu Leu Met Lys Leu Ala 
    530                 535                 540                 


Pro Arg Tyr Lys Met Pro Ser Thr Asn Ser Arg Pro Asn Ala Pro Pro 
545                 550                 555                 560 


Pro Trp Thr Leu Ala Ala Trp Ser Ala Arg Ile Arg Leu Ser Glu His 
                565                 570                 575     


Gln Gln Trp Leu His Pro Leu Pro Ser Arg Pro Pro Ala Pro Val Gln 
            580                 585                 590         


Arg Gly Glu Glu Thr Lys Thr Gln Thr 
        595                 600     


<210>  1978
<211>  1154
<212>  PRT
<213>  Homo Sapiens

<400>  1978

Met Val Cys Gly Cys Ser Ala Leu Leu Pro Leu Pro Asn Pro Arg Pro 
1               5                   10                  15      


Thr Met Pro Ala Thr Pro Asn Phe Leu Ala Asn Pro Ser Ser Ser Ser 
            20                  25                  30          


Arg Trp Ile Pro Leu Gln Pro Met Pro Val Ala Trp Ala Phe Val Gln 
        35                  40                  45              


Lys Thr Ser Ala Leu Leu Trp Leu Leu Leu Leu Gly Thr Ser Leu Ser 
    50                  55                  60                  


Pro Ala Trp Gly Gln Ala Lys Ile Pro Leu Glu Thr Val Lys Leu Trp 
65                  70                  75                  80  


Ala Asp Thr Phe Gly Gly Asp Leu Tyr Asn Thr Val Thr Lys Tyr Ser 
                85                  90                  95      


Gly Ser Leu Leu Leu Gln Lys Lys Tyr Lys Asp Val Glu Ser Ser Leu 
            100                 105                 110         


Lys Ile Glu Glu Val Asp Gly Leu Glu Leu Val Arg Lys Phe Ser Glu 
        115                 120                 125             


Asp Met Glu Asn Met Leu Arg Arg Lys Val Glu Ala Val Gln Asn Leu 
    130                 135                 140                 


Val Glu Ala Ala Glu Glu Ala Asp Leu Asn His Glu Phe Asn Glu Ser 
145                 150                 155                 160 


Leu Val Phe Asp Tyr Tyr Asn Ser Val Leu Ile Asn Glu Arg Asp Glu 
                165                 170                 175     


Lys Gly Asn Phe Val Glu Leu Gly Ala Glu Phe Leu Leu Glu Ser Asn 
            180                 185                 190         


Ala His Phe Ser Asn Leu Pro Val Asn Thr Ser Ile Ser Ser Val Gln 
        195                 200                 205             


Leu Pro Thr Asn Val Tyr Asn Lys Asp Pro Asp Ile Leu Asn Gly Val 
    210                 215                 220                 


Tyr Met Ser Glu Ala Leu Asn Ala Val Phe Val Glu Asn Phe Gln Arg 
225                 230                 235                 240 


Asp Pro Thr Leu Thr Trp Gln Tyr Phe Gly Ser Ala Thr Gly Phe Phe 
                245                 250                 255     


Arg Ile Tyr Pro Gly Ile Lys Trp Thr Pro Asp Glu Asn Gly Val Ile 
            260                 265                 270         


Thr Phe Asp Cys Arg Asn Arg Gly Trp Tyr Ile Gln Ala Ala Thr Ser 
        275                 280                 285             


Pro Lys Asp Ile Val Ile Leu Val Asp Val Ser Gly Ser Met Lys Gly 
    290                 295                 300                 


Leu Arg Met Thr Ile Ala Lys His Thr Ile Thr Thr Ile Leu Asp Thr 
305                 310                 315                 320 


Leu Gly Glu Asn Asp Phe Ile Asn Ile Ile Ala Tyr Asn Asp Tyr Val 
                325                 330                 335     


His Tyr Ile Glu Pro Cys Phe Lys Gly Ile Leu Val Gln Ala Asp Arg 
            340                 345                 350         


Asp Asn Arg Glu His Phe Lys Leu Leu Val Glu Glu Leu Met Val Lys 
        355                 360                 365             


Gly Val Gly Val Val Asp Gln Ala Leu Arg Glu Ala Phe Gln Ile Leu 
    370                 375                 380                 


Lys Gln Phe Gln Glu Ala Lys Gln Gly Ser Leu Cys Asn Gln Ala Ile 
385                 390                 395                 400 


Met Leu Ile Ser Asp Gly Ala Val Glu Asp Tyr Glu Pro Val Phe Glu 
                405                 410                 415     


Lys Tyr Asn Trp Pro Asp Cys Lys Val Arg Val Phe Thr Tyr Leu Ile 
            420                 425                 430         


Gly Arg Glu Val Ser Phe Ala Asp Arg Met Lys Trp Ile Ala Cys Asn 
        435                 440                 445             


Asn Lys Gly Tyr Tyr Thr Gln Ile Ser Thr Leu Ala Asp Thr Gln Glu 
    450                 455                 460                 


Asn Val Met Glu Tyr Leu His Val Leu Ser Arg Pro Met Val Ile Asn 
465                 470                 475                 480 


His Asp His Asp Ile Ile Trp Thr Glu Ala Tyr Met Asp Ser Lys Leu 
                485                 490                 495     


Leu Ser Ser Gln Ala Gln Ser Leu Thr Leu Leu Thr Thr Val Ala Met 
            500                 505                 510         


Pro Val Phe Ser Lys Lys Asn Glu Thr Arg Ser His Gly Ile Leu Leu 
        515                 520                 525             


Gly Val Val Gly Ser Asp Val Ala Leu Arg Glu Leu Met Lys Leu Ala 
    530                 535                 540                 


Pro Arg Tyr Lys Leu Gly Val His Gly Tyr Ala Phe Leu Asn Thr Asn 
545                 550                 555                 560 


Asn Gly Tyr Ile Leu Ser His Pro Asp Leu Arg Pro Leu Tyr Arg Glu 
                565                 570                 575     


Gly Lys Lys Leu Lys Pro Lys Pro Asn Tyr Asn Ser Val Asp Leu Ser 
            580                 585                 590         


Glu Val Glu Trp Glu Asp Gln Ala Glu Ser Leu Arg Thr Ala Met Ile 
        595                 600                 605             


Asn Arg Glu Thr Gly Thr Leu Ser Met Asp Val Lys Val Pro Met Asp 
    610                 615                 620                 


Lys Gly Lys Arg Val Leu Phe Leu Thr Asn Asp Tyr Phe Phe Thr Asp 
625                 630                 635                 640 


Ile Ser Asp Thr Pro Phe Ser Leu Gly Val Val Leu Ser Arg Gly His 
                645                 650                 655     


Gly Glu Tyr Ile Leu Leu Gly Asn Thr Ser Val Glu Glu Gly Leu His 
            660                 665                 670         


Asp Leu Leu His Pro Asp Leu Ala Leu Ala Gly Asp Trp Ile Tyr Cys 
        675                 680                 685             


Ile Thr Asp Ile Asp Pro Asp His Arg Lys Leu Ser Gln Leu Glu Ala 
    690                 695                 700                 


Met Ile Arg Phe Leu Thr Arg Lys Asp Pro Asp Leu Glu Cys Asp Glu 
705                 710                 715                 720 


Glu Leu Val Arg Glu Val Leu Phe Asp Ala Val Val Thr Ala Pro Met 
                725                 730                 735     


Glu Ala Tyr Trp Thr Ala Leu Ala Leu Asn Met Ser Glu Glu Ser Glu 
            740                 745                 750         


His Val Val Asp Met Ala Phe Leu Gly Thr Arg Ala Gly Leu Leu Arg 
        755                 760                 765             


Ser Ser Leu Phe Val Gly Ser Glu Lys Val Ser Asp Arg Lys Phe Leu 
    770                 775                 780                 


Thr Pro Glu Asp Glu Ala Ser Val Phe Thr Leu Asp Arg Phe Pro Leu 
785                 790                 795                 800 


Trp Tyr Arg Gln Ala Ser Glu His Pro Ala Gly Ser Phe Val Phe Asn 
                805                 810                 815     


Leu Arg Trp Ala Glu Gly Pro Glu Ser Ala Gly Glu Pro Met Val Val 
            820                 825                 830         


Thr Ala Ser Thr Ala Val Ala Val Thr Val Asp Lys Arg Thr Ala Ile 
        835                 840                 845             


Ala Ala Ala Ala Gly Val Gln Met Lys Leu Glu Phe Leu Gln Arg Lys 
    850                 855                 860                 


Phe Trp Ala Ala Thr Arg Gln Cys Ser Thr Val Asp Gly Pro Cys Thr 
865                 870                 875                 880 


Gln Ser Cys Glu Asp Ser Asp Leu Asp Cys Phe Val Ile Asp Asn Asn 
                885                 890                 895     


Gly Phe Ile Leu Ile Ser Lys Arg Ser Arg Glu Thr Gly Arg Phe Leu 
            900                 905                 910         


Gly Glu Val Asp Gly Ala Val Leu Thr Gln Leu Leu Ser Met Gly Val 
        915                 920                 925             


Phe Ser Gln Val Thr Met Tyr Asp Tyr Gln Ala Met Cys Lys Pro Ser 
    930                 935                 940                 


Ser His His His Ser Ala Ala Gln Pro Leu Val Ser Pro Ile Ser Ala 
945                 950                 955                 960 


Phe Leu Thr Ala Thr Arg Trp Leu Leu Gln Glu Leu Val Leu Phe Leu 
                965                 970                 975     


Leu Glu Trp Ser Val Trp Gly Ser Trp Tyr Asp Arg Gly Ala Glu Ala 
            980                 985                 990         


Lys Ser Val Phe His His Ser His  Lys His Lys Lys Gln  Asp Pro Leu 
        995                 1000                 1005             


Gln Pro  Cys Asp Thr Glu Tyr  Pro Val Phe Val Tyr  Gln Pro Ala 
    1010                 1015                 1020             


Ile Arg  Glu Ala Asn Gly Ile  Val Glu Cys Gly Pro  Cys Gln Lys 
    1025                 1030                 1035             


Val Phe  Val Val Gln Gln Ile  Pro Asn Ser Asn Leu  Leu Leu Leu 
    1040                 1045                 1050             


Val Thr  Asp Pro Thr Cys Asp  Cys Ser Ile Phe Pro  Pro Val Leu 
    1055                 1060                 1065             


Gln Glu  Ala Thr Glu Val Lys  Tyr Asn Ala Ser Val  Lys Cys Asp 
    1070                 1075                 1080             


Arg Met  Arg Ser Gln Lys Leu  Arg Arg Arg Pro Asp  Ser Cys His 
    1085                 1090                 1095             


Ala Phe  His Pro Glu Val Arg  Val Glu Ala Asp Arg  Gly Trp Ala 
    1100                 1105                 1110             


Gly Phe  Ser Ser Pro Asn Pro  Leu Cys Leu Gly Leu  Cys Pro Cys 
    1115                 1120                 1125             


Arg Gln  Glu His Ile Gly Met  Pro Met Asn Thr Pro  Val Pro Val 
    1130                 1135                 1140             


Leu Leu  Gly Gly Asn Ile Arg  Val Tyr Ala Leu 
    1145                 1150                 


<210>  1979
<211>  780
<212>  PRT
<213>  Homo Sapiens

<400>  1979

Met Val Cys Gly Cys Ser Ala Leu Leu Pro Leu Pro Asn Pro Arg Pro 
1               5                   10                  15      


Thr Met Pro Ala Thr Pro Asn Phe Leu Ala Asn Pro Ser Ser Ser Ser 
            20                  25                  30          


Arg Trp Ile Pro Leu Gln Pro Met Pro Val Ala Trp Ala Phe Val Gln 
        35                  40                  45              


Lys Thr Ser Ala Leu Leu Trp Leu Leu Leu Leu Gly Thr Ser Leu Ser 
    50                  55                  60                  


Pro Ala Trp Gly Gln Ala Lys Ile Pro Leu Glu Thr Val Lys Leu Trp 
65                  70                  75                  80  


Ala Asp Thr Phe Gly Gly Asp Leu Tyr Asn Thr Val Thr Lys Tyr Ser 
                85                  90                  95      


Gly Ser Leu Leu Leu Gln Lys Lys Tyr Lys Asp Val Glu Ser Ser Leu 
            100                 105                 110         


Lys Ile Glu Glu Val Asp Gly Leu Glu Leu Val Arg Lys Phe Ser Glu 
        115                 120                 125             


Asp Met Glu Asn Met Leu Arg Arg Lys Val Glu Ala Val Gln Asn Leu 
    130                 135                 140                 


Val Glu Ala Ala Glu Glu Ala Asp Leu Asn His Glu Phe Asn Glu Ser 
145                 150                 155                 160 


Leu Val Phe Asp Tyr Tyr Asn Ser Val Leu Ile Asn Glu Arg Asp Glu 
                165                 170                 175     


Lys Gly Asn Phe Val Glu Leu Gly Ala Glu Phe Leu Leu Glu Ser Asn 
            180                 185                 190         


Ala His Phe Ser Asn Leu Pro Val Asn Thr Ser Ile Ser Ser Val Gln 
        195                 200                 205             


Leu Pro Thr Asn Val Tyr Asn Lys Asp Pro Asp Ile Leu Asn Gly Val 
    210                 215                 220                 


Tyr Met Ser Glu Ala Leu Asn Ala Val Phe Val Glu Asn Phe Gln Arg 
225                 230                 235                 240 


Asp Pro Thr Leu Thr Trp Gln Tyr Phe Gly Ser Ala Thr Gly Phe Phe 
                245                 250                 255     


Arg Ile Tyr Pro Gly Ile Leu Val Gln Ala Asp Arg Asp Asn Arg Glu 
            260                 265                 270         


His Phe Lys Leu Leu Val Glu Glu Leu Met Val Lys Gly Val Gly Val 
        275                 280                 285             


Val Asp Gln Ala Leu Arg Glu Ala Phe Gln Ile Leu Lys Gln Phe Gln 
    290                 295                 300                 


Glu Ala Lys Gln Gly Ser Leu Cys Asn Gln Ala Ile Met Leu Ile Ser 
305                 310                 315                 320 


Asp Gly Ala Val Glu Asp Tyr Glu Pro Val Phe Glu Lys Tyr Asn Trp 
                325                 330                 335     


Pro Asp Cys Lys Ile Ser Thr Leu Ala Asp Thr Gln Glu Asn Val Met 
            340                 345                 350         


Glu Tyr Leu His Val Leu Ser Arg Pro Met Val Ile Asn His Asp His 
        355                 360                 365             


Asp Ile Ile Trp Thr Glu Ala Tyr Met Asp Ser Lys Leu Leu Ser Ser 
    370                 375                 380                 


Gln Ala Gln Ser Leu Thr Leu Leu Thr Thr Val Ala Met Pro Val Phe 
385                 390                 395                 400 


Ser Lys Lys Asn Glu Thr Arg Ser His Gly Ile Leu Leu Gly Val Val 
                405                 410                 415     


Gly Ser Asp Val Ala Leu Arg Glu Leu Met Lys Leu Ala Pro Arg Tyr 
            420                 425                 430         


Lys Leu Gly Val His Gly Tyr Ala Phe Leu Asn Thr Asn Asn Gly Tyr 
        435                 440                 445             


Ile Leu Ser His Pro Asp Leu Arg Pro Leu Tyr Arg Glu Gly Lys Lys 
    450                 455                 460                 


Leu Lys Pro Lys Pro Asn Tyr Asn Ser Val Asp Leu Ser Glu Val Glu 
465                 470                 475                 480 


Trp Glu Asp Gln Ala Glu Ser Lys Arg Val Leu Phe Leu Thr Asn Asp 
                485                 490                 495     


Tyr Phe Phe Thr Asp Ile Ser Asp Thr Pro Phe Ser Leu Gly Val Val 
            500                 505                 510         


Leu Ser Arg Gly His Gly Glu Tyr Ile Leu Leu Gly Asn Thr Ser Val 
        515                 520                 525             


Glu Glu Gly Leu His Asp Leu Leu His Pro Asp Leu Ala Leu Ala Gly 
    530                 535                 540                 


Asp Trp Ile Tyr Cys Ile Thr Asp Ile Asp Pro Asp His Arg Lys Leu 
545                 550                 555                 560 


Ser Gln Leu Glu Ala Met Ile Arg Phe Leu Thr Arg Lys Asp Pro Asp 
                565                 570                 575     


Leu Glu Cys Asp Glu Glu Leu Val Arg Glu Val Leu Phe Asp Ala Val 
            580                 585                 590         


Val Thr Ala Pro Met Glu Ala Tyr Trp Thr Ala Leu Ala Leu Asn Met 
        595                 600                 605             


Ser Glu Glu Ser Glu His Val Val Asp Met Ala Phe Leu Gly Thr Arg 
    610                 615                 620                 


Ala Gly Leu Leu Arg Ser Ser Leu Phe Val Gly Ser Glu Lys Val Ser 
625                 630                 635                 640 


Asp Arg Lys Phe Leu Thr Pro Glu Asp Glu Ala Ser Val Phe Thr Leu 
                645                 650                 655     


Asp Arg Phe Pro Leu Trp Tyr Arg Gln Ala Ser Glu His Pro Ala Gly 
            660                 665                 670         


Ser Phe Val Phe Asn Leu Arg Trp Ala Glu Gly Pro Glu Ser Ala Gly 
        675                 680                 685             


Glu Pro Met Val Val Thr Ala Ser Thr Ala Val Ala Val Thr Val Asp 
    690                 695                 700                 


Lys Arg Thr Ala Ile Ala Ala Ala Ala Gly Val Gln Met Lys Leu Glu 
705                 710                 715                 720 


Phe Leu Gln Arg Lys Phe Trp Ala Ala Thr Arg Gln Cys Ser Thr Val 
                725                 730                 735     


Asp Gly Pro Cys Thr Gln Ser Cys Glu Asp Ser Asp Leu Asp Cys Phe 
            740                 745                 750         


Val Ile Asp Asn Asn Gly Phe Ile Leu Ile Ser Lys Arg Ser Arg Glu 
        755                 760                 765             


Pro Gly Ile Lys Leu Arg Lys Lys Pro Ile Gln Thr 
    770                 775                 780 


<210>  1980
<211>  1112
<212>  PRT
<213>  Homo Sapiens

<400>  1980

Met Val Cys Gly Cys Ser Ala Leu Leu Pro Leu Pro Asn Pro Arg Pro 
1               5                   10                  15      


Thr Met Pro Ala Thr Pro Asn Phe Leu Ala Asn Pro Ser Ser Ser Ser 
            20                  25                  30          


Arg Trp Ile Pro Leu Gln Pro Met Pro Val Ala Trp Ala Phe Val Gln 
        35                  40                  45              


Lys Thr Ser Ala Leu Leu Trp Leu Leu Leu Leu Gly Thr Ser Leu Ser 
    50                  55                  60                  


Pro Ala Trp Gly Gln Ala Lys Ile Pro Leu Glu Thr Val Lys Leu Trp 
65                  70                  75                  80  


Ala Asp Thr Phe Gly Gly Asp Leu Tyr Asn Thr Val Thr Lys Tyr Ser 
                85                  90                  95      


Gly Ser Leu Leu Leu Gln Lys Lys Tyr Lys Asp Val Glu Ser Ser Leu 
            100                 105                 110         


Lys Ile Glu Glu Val Asp Gly Leu Glu Leu Val Arg Lys Phe Ser Glu 
        115                 120                 125             


Asp Met Glu Asn Met Leu Arg Arg Lys Val Glu Ala Val Gln Asn Leu 
    130                 135                 140                 


Val Glu Ala Ala Glu Glu Ala Asp Leu Asn His Glu Phe Asn Glu Ser 
145                 150                 155                 160 


Leu Val Phe Asp Tyr Tyr Asn Ser Val Leu Ile Asn Glu Arg Asp Glu 
                165                 170                 175     


Lys Gly Asn Phe Val Glu Leu Gly Ala Glu Phe Leu Leu Glu Ser Asn 
            180                 185                 190         


Ala His Phe Ser Asn Leu Pro Val Asn Thr Ser Ile Ser Ser Val Gln 
        195                 200                 205             


Leu Pro Thr Asn Val Tyr Asn Lys Asp Pro Asp Ile Leu Asn Gly Val 
    210                 215                 220                 


Tyr Met Ser Glu Ala Leu Asn Ala Val Phe Val Glu Asn Phe Gln Arg 
225                 230                 235                 240 


Asp Pro Thr Leu Thr Trp Gln Tyr Phe Gly Ser Ala Thr Gly Phe Phe 
                245                 250                 255     


Arg Ile Tyr Pro Gly Ile Lys Trp Thr Pro Asp Glu Asn Gly Val Ile 
            260                 265                 270         


Thr Phe Asp Cys Arg Asn Arg Gly Trp Tyr Ile Gln Ala Ala Thr Ser 
        275                 280                 285             


Pro Lys Asp Ile Val Ile Leu Val Asp Val Ser Gly Ser Met Lys Gly 
    290                 295                 300                 


Leu Arg Met Thr Ile Ala Lys His Thr Ile Thr Thr Ile Leu Asp Thr 
305                 310                 315                 320 


Leu Gly Glu Asn Asp Phe Ile Asn Ile Ile Ala Tyr Asn Asp Tyr Val 
                325                 330                 335     


His Tyr Ile Glu Pro Cys Phe Lys Gly Ile Leu Val Gln Ala Asp Arg 
            340                 345                 350         


Asp Asn Arg Glu His Phe Lys Leu Leu Val Glu Glu Leu Met Val Lys 
        355                 360                 365             


Gly Val Gly Val Val Asp Gln Ala Leu Arg Glu Ala Phe Gln Ile Leu 
    370                 375                 380                 


Lys Gln Phe Gln Glu Ala Lys Gln Gly Ser Leu Cys Asn Gln Ala Ile 
385                 390                 395                 400 


Met Leu Ile Ser Asp Gly Ala Val Glu Asp Tyr Glu Pro Val Phe Glu 
                405                 410                 415     


Lys Tyr Asn Trp Pro Asp Cys Lys Val Arg Val Phe Thr Tyr Leu Ile 
            420                 425                 430         


Gly Arg Glu Val Ser Phe Ala Asp Arg Met Lys Trp Ile Ala Cys Asn 
        435                 440                 445             


Asn Lys Gly Tyr Tyr Thr Gln Ile Ser Thr Leu Ala Asp Thr Gln Glu 
    450                 455                 460                 


Asn Val Met Glu Tyr Leu His Val Leu Ser Arg Pro Met Val Ile Asn 
465                 470                 475                 480 


His Asp His Asp Ile Ile Trp Thr Glu Ala Tyr Met Asp Ser Lys Leu 
                485                 490                 495     


Leu Ser Ser Gln Ala Gln Ser Leu Thr Leu Leu Thr Thr Val Ala Met 
            500                 505                 510         


Pro Val Phe Ser Lys Lys Asn Glu Thr Arg Ser His Gly Ile Leu Leu 
        515                 520                 525             


Gly Val Val Gly Ser Asp Val Ala Leu Arg Glu Leu Met Lys Leu Ala 
    530                 535                 540                 


Pro Arg Tyr Lys Tyr Arg Glu Gly Lys Lys Leu Lys Pro Lys Pro Asn 
545                 550                 555                 560 


Tyr Asn Ser Val Asp Leu Ser Glu Val Glu Trp Glu Asp Gln Ala Glu 
                565                 570                 575     


Ser Leu Arg Thr Ala Met Ile Asn Arg Glu Thr Gly Thr Leu Ser Met 
            580                 585                 590         


Asp Val Lys Val Pro Met Asp Lys Gly Lys Arg Val Leu Phe Leu Thr 
        595                 600                 605             


Asn Asp Tyr Phe Phe Thr Asp Ile Ser Asp Thr Pro Phe Ser Leu Gly 
    610                 615                 620                 


Val Val Leu Ser Arg Gly His Gly Glu Tyr Ile Leu Leu Gly Asn Thr 
625                 630                 635                 640 


Ser Val Glu Glu Gly Leu His Asp Leu Leu His Pro Asp Leu Ala Leu 
                645                 650                 655     


Ala Gly Asp Trp Ile Tyr Cys Ile Thr Asp Ile Asp Pro Asp His Arg 
            660                 665                 670         


Lys Leu Ser Gln Leu Glu Ala Met Ile Arg Phe Leu Thr Arg Lys Asp 
        675                 680                 685             


Pro Asp Leu Glu Cys Asp Glu Glu Leu Val Arg Glu Val Leu Phe Asp 
    690                 695                 700                 


Ala Val Val Thr Ala Pro Met Glu Ala Tyr Trp Thr Ala Leu Ala Leu 
705                 710                 715                 720 


Asn Met Ser Glu Glu Ser Glu His Val Val Asp Met Ala Phe Leu Gly 
                725                 730                 735     


Thr Arg Ala Gly Leu Leu Arg Ser Ser Leu Phe Val Gly Ser Glu Lys 
            740                 745                 750         


Val Ser Asp Arg Lys Phe Leu Thr Pro Glu Asp Glu Ala Ser Val Phe 
        755                 760                 765             


Thr Leu Asp Arg Phe Pro Leu Trp Tyr Arg Gln Ala Ser Glu His Pro 
    770                 775                 780                 


Ala Gly Ser Phe Val Phe Asn Leu Arg Trp Ala Glu Gly Pro Glu Ser 
785                 790                 795                 800 


Ala Gly Glu Pro Met Val Val Thr Ala Ser Thr Ala Val Ala Val Thr 
                805                 810                 815     


Val Asp Lys Arg Thr Ala Ile Ala Ala Ala Ala Gly Val Gln Met Lys 
            820                 825                 830         


Leu Glu Phe Leu Gln Arg Lys Phe Trp Ala Ala Thr Arg Gln Cys Ser 
        835                 840                 845             


Thr Val Asp Gly Pro Cys Thr Gln Ser Cys Glu Asp Ser Asp Leu Asp 
    850                 855                 860                 


Cys Phe Val Ile Asp Asn Asn Gly Phe Ile Leu Ile Ser Lys Arg Ser 
865                 870                 875                 880 


Arg Glu Thr Gly Arg Phe Leu Gly Glu Val Asp Gly Ala Val Leu Thr 
                885                 890                 895     


Gln Leu Leu Ser Met Gly Val Phe Ser Gln Val Thr Met Tyr Asp Tyr 
            900                 905                 910         


Gln Ala Met Cys Lys Pro Ser Ser His His His Ser Ala Ala Gln Pro 
        915                 920                 925             


Leu Val Ser Pro Ile Ser Ala Phe Leu Thr Ala Thr Arg Trp Leu Leu 
    930                 935                 940                 


Gln Glu Leu Val Leu Phe Leu Leu Glu Trp Ser Val Trp Gly Ser Trp 
945                 950                 955                 960 


Tyr Asp Arg Gly Ala Glu Ala Lys Ser Val Phe His His Ser His Lys 
                965                 970                 975     


His Lys Lys Gln Asp Pro Leu Gln Pro Cys Asp Thr Glu Tyr Pro Val 
            980                 985                 990         


Phe Val Tyr Gln Pro Ala Ile Arg  Glu Ala Asn Gly Ile  Val Glu Cys 
        995                 1000                 1005             


Gly Pro  Cys Gln Lys Val Phe  Val Val Gln Gln Ile  Pro Asn Ser 
    1010                 1015                 1020             


Asn Leu  Leu Leu Leu Val Thr  Asp Pro Thr Cys Asp  Cys Ser Ile 
    1025                 1030                 1035             


Phe Pro  Pro Val Leu Gln Glu  Ala Thr Glu Val Lys  Tyr Asn Ala 
    1040                 1045                 1050             


Ser Val  Lys Cys Asp Arg Met  Arg Ser Gln Lys Leu  Arg Arg Arg 
    1055                 1060                 1065             


Pro Asp  Ser Cys His Ala Phe  His Pro Glu Glu Asn  Ala Gln Asp 
    1070                 1075                 1080             


Cys Gly  Gly Ala Ser Asp Thr  Ser Ala Ser Pro Pro  Leu Leu Leu 
    1085                 1090                 1095             


Leu Pro  Val Cys Ala Trp Gly  Leu Leu Pro Gln Leu  Leu Arg 
    1100                 1105                 1110         


<210>  1981
<211>  192
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1981

Xaa Glu Leu Val Arg Glu Val Leu Phe Asp Ala Val Val Thr Ala Pro 
1               5                   10                  15      


Met Glu Ala Tyr Trp Thr Ala Leu Ala Leu Asn Met Ser Glu Glu Ser 
            20                  25                  30          


Glu His Val Val Asp Met Ala Phe Leu Gly Thr Arg Ala Gly Leu Leu 
        35                  40                  45              


Arg Ser Ser Leu Phe Val Gly Ser Glu Lys Val Ser Asp Arg Lys Phe 
    50                  55                  60                  


Leu Thr Pro Glu Asp Glu Ala Ser Val Phe Thr Leu Asp Arg Phe Pro 
65                  70                  75                  80  


Leu Trp Tyr Arg Gln Ala Ser Glu His Pro Ala Gly Ser Phe Val Phe 
                85                  90                  95      


Asn Leu Arg Trp Ala Glu Gly Pro Glu Ser Ala Gly Glu Pro Met Val 
            100                 105                 110         


Val Thr Ala Ser Thr Ala Val Ala Val Thr Val Asp Lys Arg Thr Ala 
        115                 120                 125             


Ile Ala Ala Ala Ala Gly Val Gln Met Lys Leu Glu Phe Leu Gln Arg 
    130                 135                 140                 


Lys Phe Trp Ala Ala Thr Arg Gln Cys Ser Thr Val Asp Gly Pro Cys 
145                 150                 155                 160 


Thr Gln Ser Cys Glu Asp Ser Asp Leu Asp Cys Phe Val Ile Asp Asn 
                165                 170                 175     


Asn Gly Phe Ile Leu Ile Ser Lys Arg Ser Arg Glu Ser Asp Tyr Val 
            180                 185                 190         


<210>  1982
<211>  284
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  1982

Xaa Gly Val Gln Met Lys Leu Glu Phe Leu Gln Arg Lys Phe Trp Ala 
1               5                   10                  15      


Ala Thr Arg Gln Cys Ser Thr Val Asp Gly Pro Cys Thr Gln Ser Cys 
            20                  25                  30          


Glu Asp Ser Asp Leu Asp Cys Phe Val Ile Asp Asn Asn Gly Phe Ile 
        35                  40                  45              


Leu Ile Ser Lys Arg Ser Arg Glu Thr Gly Arg Phe Leu Gly Glu Val 
    50                  55                  60                  


Asp Gly Ala Val Leu Thr Gln Leu Leu Ser Met Gly Val Phe Ser Gln 
65                  70                  75                  80  


Val Thr Met Tyr Asp Tyr Gln Ala Met Cys Lys Pro Ser Ser His His 
                85                  90                  95      


His Ser Ala Ala Gln Pro Leu Pro Ile Ser Ala Phe Leu Thr Ala Thr 
            100                 105                 110         


Arg Trp Leu Leu Gln Glu Leu Val Leu Phe Leu Leu Glu Trp Ser Val 
        115                 120                 125             


Trp Gly Ser Trp Tyr Asp Arg Gly Ala Glu Ala Lys Ser Val Phe His 
    130                 135                 140                 


His Ser His Lys His Lys Lys Gln Asp Pro Leu Gln Pro Cys Asp Thr 
145                 150                 155                 160 


Glu Tyr Pro Val Phe Val Tyr Gln Pro Ala Ile Arg Glu Ala Asn Gly 
                165                 170                 175     


Ile Val Glu Cys Gly Pro Cys Gln Lys Val Phe Val Val Gln Gln Ile 
            180                 185                 190         


Pro Asn Ser Asn Leu Leu Leu Leu Val Thr Asp Pro Thr Cys Asp Cys 
        195                 200                 205             


Ser Ile Phe Pro Pro Val Leu Gln Glu Ala Thr Glu Val Lys Tyr Asn 
    210                 215                 220                 


Ala Ser Val Lys Cys Asp Arg Met Arg Ser Gln Lys Leu Arg Arg Arg 
225                 230                 235                 240 


Pro Asp Ser Cys His Ala Phe His Pro Glu Glu Asn Ala Gln Asp Cys 
                245                 250                 255     


Gly Gly Ala Ser Asp Thr Ser Ala Ser Pro Pro Leu Leu Leu Leu Pro 
            260                 265                 270         


Val Cys Ala Trp Gly Leu Leu Pro Gln Leu Leu Arg 
        275                 280                 


<210>  1983
<211>  234
<212>  PRT
<213>  Homo Sapiens

<400>  1983

Met Gly Ala Pro Ala Ala Ser Leu Leu Leu Leu Leu Leu Leu Phe Ala 
1               5                   10                  15      


Cys Cys Trp Ala Pro Gly Gly Ala Asn Leu Ser Gln Asp Asp Ser Gln 
            20                  25                  30          


Pro Trp Thr Ser Asp Glu Thr Val Val Ala Gly Gly Thr Val Val Leu 
        35                  40                  45              


Lys Cys Gln Val Lys Asp His Glu Asp Ser Ser Leu Gln Trp Ser Asn 
    50                  55                  60                  


Pro Ala Gln Gln Thr Leu Tyr Phe Gly Glu Lys Arg Ala Leu Arg Asp 
65                  70                  75                  80  


Asn Arg Ile Gln Leu Val Thr Ser Thr Pro His Glu Leu Ser Ile Ser 
                85                  90                  95      


Ile Ser Asn Val Ala Leu Ala Asp Glu Gly Glu Tyr Thr Cys Ser Ile 
            100                 105                 110         


Phe Thr Met Pro Val Arg Thr Ala Lys Ser Leu Val Thr Val Leu Gly 
        115                 120                 125             


Ile Pro Gln Lys Pro Ile Ile Thr Gly Tyr Lys Ser Ser Leu Arg Glu 
    130                 135                 140                 


Lys Asp Thr Ala Thr Leu Asn Cys Gln Ser Ser Gly Ser Lys Pro Ala 
145                 150                 155                 160 


Ala Arg Leu Thr Trp Arg Lys Gly Asp Gln Glu Leu His Gly Glu Pro 
                165                 170                 175     


Thr Arg Ile Gln Glu Asp Pro Asn Asp Thr Pro Thr Ala Met Ile Arg 
            180                 185                 190         


Pro Asp Pro Pro His Pro Arg Glu Gly Gln Lys Leu Leu Leu His Cys 
        195                 200                 205             


Glu Gly Arg Gly Asn Pro Val Pro Gln Gln Tyr Leu Trp Glu Lys Glu 
    210                 215                 220                 


Gly Ser Val Pro Pro Leu Lys Met Thr Gln 
225                 230                 


<210>  1984
<211>  398
<212>  PRT
<213>  Homo Sapiens

<400>  1984

Met Gly Ala Pro Ala Ala Ser Leu Leu Leu Leu Leu Leu Leu Phe Ala 
1               5                   10                  15      


Cys Cys Trp Ala Pro Gly Gly Ala Asn Leu Ser Gln Asp Asp Ser Gln 
            20                  25                  30          


Pro Trp Thr Ser Asp Glu Thr Val Val Ala Gly Gly Thr Val Val Leu 
        35                  40                  45              


Lys Cys Gln Val Lys Asp His Glu Asp Ser Ser Leu Gln Trp Ser Asn 
    50                  55                  60                  


Pro Ala Gln Gln Thr Leu Tyr Phe Gly Glu Lys Arg Ala Leu Arg Asp 
65                  70                  75                  80  


Asn Arg Ile Gln Leu Val Thr Ser Thr Pro His Glu Leu Ser Ile Ser 
                85                  90                  95      


Ile Ser Asn Val Ala Leu Ala Asp Glu Gly Glu Tyr Thr Cys Ser Ile 
            100                 105                 110         


Phe Thr Met Pro Val Arg Thr Ala Lys Ser Leu Val Thr Val Leu Gly 
        115                 120                 125             


Ile Pro Gln Lys Pro Ile Ile Thr Gly Tyr Lys Ser Ser Leu Arg Glu 
    130                 135                 140                 


Lys Asp Thr Ala Thr Leu Asn Cys Gln Ser Ser Gly Ser Lys Pro Ala 
145                 150                 155                 160 


Ala Arg Leu Thr Trp Arg Lys Gly Asp Gln Glu Leu His Gly Glu Pro 
                165                 170                 175     


Thr Arg Ile Gln Glu Asp Pro Asn Gly Lys Thr Phe Thr Val Ser Ser 
            180                 185                 190         


Ser Val Thr Phe Gln Val Thr Arg Glu Asp Asp Gly Ala Ser Ile Val 
        195                 200                 205             


Cys Ser Val Asn His Glu Ser Leu Lys Gly Ala Asp Arg Ser Thr Ser 
    210                 215                 220                 


Gln Arg Ile Glu Val Leu Tyr Thr Pro Thr Ala Met Ile Arg Pro Asp 
225                 230                 235                 240 


Pro Pro His Pro Arg Glu Gly Gln Lys Leu Leu Leu His Cys Glu Gly 
                245                 250                 255     


Arg Gly Asn Pro Val Pro Gln Gln Tyr Leu Trp Glu Lys Glu Gly Ser 
            260                 265                 270         


Val Pro Pro Leu Lys Met Thr Gln Glu Ser Ala Leu Ile Phe Pro Phe 
        275                 280                 285             


Leu Asn Lys Ser Asp Ser Gly Thr Tyr Gly Cys Thr Ala Thr Ser Asn 
    290                 295                 300                 


Met Gly Ser Tyr Lys Ala Tyr Tyr Thr Leu Asn Val Asn Asp Pro Ser 
305                 310                 315                 320 


Pro Val Pro Ser Ser Ser Ser Thr Tyr His Ala Ile Ile Gly Gly Ile 
                325                 330                 335     


Val Ala Phe Ile Val Phe Leu Leu Leu Ile Met Leu Ile Phe Leu Gly 
            340                 345                 350         


His Tyr Leu Ile Arg His Lys Gly Thr Tyr Leu Thr His Glu Ala Lys 
        355                 360                 365             


Gly Ser Asp Asp Ala Pro Asp Ala Asp Thr Ala Ile Ile Asn Ala Glu 
    370                 375                 380                 


Gly Gly Gln Ser Gly Gly Asp Asp Lys Lys Glu Tyr Phe Ile 
385                 390                 395             


<210>  1985
<211>  432
<212>  PRT
<213>  Homo Sapiens

<400>  1985

Met Gly Ala Pro Ala Ala Ser Leu Leu Leu Leu Leu Leu Leu Phe Ala 
1               5                   10                  15      


Cys Cys Trp Ala Pro Gly Gly Ala Asn Leu Ser Gln Asp Gly Tyr Trp 
            20                  25                  30          


Gln Glu Gln Asp Leu Glu Leu Gly Thr Leu Ala Pro Leu Asp Glu Ala 
        35                  40                  45              


Ile Ser Ser Thr Val Trp Ser Ser Pro Asp Met Leu Ala Ser Gln Asp 
    50                  55                  60                  


Ser Gln Pro Trp Thr Ser Asp Glu Thr Val Val Ala Gly Gly Thr Val 
65                  70                  75                  80  


Val Leu Lys Cys Gln Val Lys Asp His Glu Asp Ser Ser Leu Gln Trp 
                85                  90                  95      


Ser Asn Pro Ala Gln Gln Thr Leu Tyr Phe Gly Glu Lys Arg Ala Leu 
            100                 105                 110         


Arg Asp Asn Arg Ile Gln Leu Val Thr Ser Thr Pro His Glu Leu Ser 
        115                 120                 125             


Ile Ser Ile Ser Asn Val Ala Leu Ala Asp Glu Gly Glu Tyr Thr Cys 
    130                 135                 140                 


Ser Ile Phe Thr Met Pro Val Arg Thr Ala Lys Ser Leu Val Thr Val 
145                 150                 155                 160 


Leu Gly Ile Pro Gln Lys Pro Ile Ile Thr Gly Tyr Lys Ser Ser Leu 
                165                 170                 175     


Arg Glu Lys Asp Thr Ala Thr Leu Asn Cys Gln Ser Ser Gly Ser Lys 
            180                 185                 190         


Pro Ala Ala Arg Leu Thr Trp Arg Lys Gly Asp Gln Glu Leu His Gly 
        195                 200                 205             


Glu Pro Thr Arg Ile Gln Glu Asp Pro Asn Gly Lys Thr Phe Thr Val 
    210                 215                 220                 


Ser Ser Ser Val Thr Phe Gln Val Thr Arg Glu Asp Asp Gly Ala Ser 
225                 230                 235                 240 


Ile Val Cys Ser Val Asn His Glu Ser Leu Lys Gly Ala Asp Arg Ser 
                245                 250                 255     


Thr Ser Gln Arg Ile Glu Val Leu Tyr Thr Pro Thr Ala Met Ile Arg 
            260                 265                 270         


Pro Asp Pro Pro His Pro Arg Glu Gly Gln Lys Leu Leu Leu His Cys 
        275                 280                 285             


Glu Gly Arg Gly Asn Pro Val Pro Gln Gln Tyr Leu Trp Glu Lys Glu 
    290                 295                 300                 


Gly Ser Val Pro Pro Leu Lys Met Thr Gln Glu Ser Ala Leu Ile Phe 
305                 310                 315                 320 


Pro Phe Leu Asn Lys Ser Asp Ser Gly Thr Tyr Gly Cys Thr Ala Thr 
                325                 330                 335     


Ser Asn Met Gly Ser Tyr Lys Ala Tyr Tyr Thr Leu Asn Val Asn Asp 
            340                 345                 350         


Pro Ser Pro Val Pro Ser Ser Ser Ser Thr Tyr His Ala Ile Ile Gly 
        355                 360                 365             


Gly Ile Val Ala Phe Ile Val Phe Leu Leu Leu Ile Met Leu Ile Phe 
    370                 375                 380                 


Leu Gly His Tyr Leu Ile Arg His Lys Gly Thr Tyr Leu Thr His Glu 
385                 390                 395                 400 


Ala Lys Gly Ser Asp Asp Ala Pro Asp Ala Asp Thr Ala Ile Ile Asn 
                405                 410                 415     


Ala Glu Gly Gly Gln Ser Gly Gly Asp Asp Lys Lys Glu Tyr Phe Ile 
            420                 425                 430         


<210>  1986
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  1986

Met Gly Phe Gln Lys Phe Ser Pro Phe Leu Ala Leu Ser Ile Leu Val 
1               5                   10                  15      


Leu Leu Gln Ala Gly Ser Leu His Ala Ala Pro Phe Arg Ser Ala Leu 
            20                  25                  30          


Glu Ser Ser Pro Ala Asp Pro Ala Thr Leu Ser Glu Asp Glu Ala Arg 
        35                  40                  45              


Leu Leu Leu Ala Ala Leu Val Gln Asp Tyr Val Gln Met Lys Ala Ser 
    50                  55                  60                  


Glu Leu Glu Gln Glu Gln Glu Arg Glu Gly Ser Arg Ile Ile Ala Gln 
65                  70                  75                  80  


Lys Arg Ala Cys Asp Thr Ala Thr Cys Val Thr His Arg Leu Ala Gly 
                85                  90                  95      


Leu Leu Ser Arg Ser Gly Gly Val Val Lys Asn Asn Phe Val Pro Thr 
            100                 105                 110         


Asn Val Gly Ser Lys Ala Phe Gly Arg Arg Arg Arg Asp Leu Gln Ala 
        115                 120                 125             


<210>  1987
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  1987

Met Gly Phe Gln Lys Phe Ser Pro Phe Leu Ala Leu Ser Ile Leu Val 
1               5                   10                  15      


Leu Leu Gln Ala Gly Ser Leu His Ala Ala Pro Phe Arg Ser Ala Leu 
            20                  25                  30          


Glu Ser Ser Pro Ala Asp Pro Ala Thr Leu Ser Glu Asp Glu Ala Arg 
        35                  40                  45              


Leu Leu Leu Ala Ala Leu Val Gln Asp Tyr Val Gln Met Lys Ala Ser 
    50                  55                  60                  


Glu Leu Glu Gln Glu Gln Glu Arg Glu Gly Ser Arg Ile Ile Ala Gln 
65                  70                  75                  80  


Lys Arg Ala Cys Asp Thr Ala Thr Cys Val Thr His Arg Leu Ala Gly 
                85                  90                  95      


Leu Leu Ser Arg Ser Gly Gly Val Val Lys Asn Asn Phe Val Pro Thr 
            100                 105                 110         


Asn Val Gly Ser Lys Ala Phe Gly Arg Arg Arg Arg Asp Leu Gln Ala 
        115                 120                 125             


<210>  1988
<211>  141
<212>  PRT
<213>  Homo Sapiens

<400>  1988

Met Gly Phe Gln Lys Phe Ser Pro Phe Leu Ala Leu Ser Ile Leu Val 
1               5                   10                  15      


Leu Leu Gln Ala Gly Ser Leu His Ala Ala Pro Phe Arg Ser Ala Leu 
            20                  25                  30          


Glu Ser Ser Pro Ala Asp Pro Ala Thr Leu Ser Glu Asp Glu Ala Arg 
        35                  40                  45              


Leu Leu Leu Ala Ala Leu Val Gln Asp Tyr Val Gln Met Lys Ala Ser 
    50                  55                  60                  


Glu Leu Glu Gln Glu Gln Glu Arg Glu Gly Ser Ser Leu Asp Ser Pro 
65                  70                  75                  80  


Arg Ser Lys Arg Cys Gly Asn Leu Ser Thr Cys Met Leu Gly Thr Tyr 
                85                  90                  95      


Thr Gln Asp Phe Asn Lys Phe His Thr Phe Pro Gln Thr Ala Ile Gly 
            100                 105                 110         


Val Gly Ala Pro Gly Lys Lys Arg Asp Met Ser Ser Asp Leu Glu Arg 
        115                 120                 125             


Asp His Arg Pro His Asn His Cys Pro Glu Glu Ser Leu 
    130                 135                 140     


<210>  1989
<211>  141
<212>  PRT
<213>  Homo Sapiens

<400>  1989

Met Gly Phe Gln Lys Phe Ser Pro Phe Leu Ala Leu Ser Ile Leu Val 
1               5                   10                  15      


Leu Leu Gln Ala Gly Ser Leu His Ala Ala Pro Phe Arg Ser Ala Leu 
            20                  25                  30          


Glu Ser Ser Pro Ala Asp Pro Ala Thr Leu Ser Glu Asp Glu Ala Arg 
        35                  40                  45              


Leu Leu Leu Ala Ala Leu Val Gln Asp Tyr Val Gln Met Lys Ala Ser 
    50                  55                  60                  


Glu Leu Glu Gln Glu Gln Glu Arg Glu Gly Ser Ser Leu Asp Ser Pro 
65                  70                  75                  80  


Arg Ser Lys Arg Cys Gly Asn Leu Ser Thr Cys Met Leu Gly Thr Tyr 
                85                  90                  95      


Thr Gln Asp Phe Asn Lys Phe His Thr Phe Pro Gln Thr Ala Ile Gly 
            100                 105                 110         


Val Gly Ala Pro Gly Lys Lys Arg Asp Met Ser Ser Asp Leu Glu Arg 
        115                 120                 125             


Asp His Arg Pro His Val Ser Met Pro Gln Asn Ala Asn 
    130                 135                 140     


<210>  1990
<211>  141
<212>  PRT
<213>  Homo Sapiens

<400>  1990

Met Gly Phe Gln Lys Phe Ser Pro Phe Leu Ala Leu Ser Ile Leu Val 
1               5                   10                  15      


Leu Leu Gln Ala Gly Ser Leu His Ala Ala Pro Phe Arg Ser Ala Leu 
            20                  25                  30          


Glu Ser Ser Pro Ala Asp Pro Ala Thr Leu Ser Glu Asp Glu Ala Arg 
        35                  40                  45              


Leu Leu Leu Ala Ala Leu Val Gln Asp Tyr Val Gln Met Lys Ala Ser 
    50                  55                  60                  


Glu Leu Glu Gln Glu Gln Glu Arg Glu Gly Ser Ser Leu Asp Ser Pro 
65                  70                  75                  80  


Arg Ser Lys Arg Cys Gly Asn Leu Ser Thr Cys Met Leu Gly Thr Tyr 
                85                  90                  95      


Thr Gln Asp Phe Asn Lys Phe His Thr Phe Pro Gln Thr Ala Ile Gly 
            100                 105                 110         


Val Gly Ala Pro Gly Lys Lys Arg Asp Met Ser Ser Asp Leu Glu Arg 
        115                 120                 125             


Asp His Arg Pro His Val Ser Met Pro Gln Asn Ala Asn 
    130                 135                 140     


<210>  1991
<211>  127
<212>  PRT
<213>  Homo Sapiens

<400>  1991

Met Gly Phe Arg Lys Phe Ser Pro Phe Leu Ala Leu Ser Ile Leu Val 
1               5                   10                  15      


Leu Tyr Gln Ala Gly Ser Leu Gln Ala Ala Pro Phe Arg Ser Ala Leu 
            20                  25                  30          


Glu Ser Ser Pro Asp Pro Ala Thr Leu Ser Lys Glu Asp Ala Arg Leu 
        35                  40                  45              


Leu Leu Ala Ala Leu Val Gln Asp Tyr Val Gln Met Lys Ala Ser Glu 
    50                  55                  60                  


Leu Lys Gln Glu Gln Glu Thr Gln Gly Ser Ser Ser Ala Ala Gln Lys 
65                  70                  75                  80  


Arg Ala Cys Asn Thr Ala Thr Cys Val Thr His Arg Leu Ala Gly Leu 
                85                  90                  95      


Leu Ser Arg Ser Gly Gly Met Val Lys Ser Asn Phe Val Pro Thr Asn 
            100                 105                 110         


Val Gly Ser Lys Ala Phe Gly Arg Arg Arg Arg Asp Leu Gln Ala 
        115                 120                 125         


<210>  1992
<211>  127
<212>  PRT
<213>  Homo Sapiens

<400>  1992

Met Gly Phe Arg Lys Phe Ser Pro Phe Leu Ala Leu Ser Ile Leu Val 
1               5                   10                  15      


Leu Tyr Gln Ala Gly Ser Leu Gln Ala Ala Pro Phe Arg Ser Ala Leu 
            20                  25                  30          


Glu Ser Ser Pro Asp Pro Ala Thr Leu Ser Lys Glu Asp Ala Arg Leu 
        35                  40                  45              


Leu Leu Ala Ala Leu Val Gln Asp Tyr Val Gln Met Lys Ala Ser Glu 
    50                  55                  60                  


Leu Lys Gln Glu Gln Glu Thr Gln Gly Ser Ser Ser Ala Ala Gln Lys 
65                  70                  75                  80  


Arg Ala Cys Asn Thr Ala Thr Cys Val Thr His Arg Leu Ala Gly Leu 
                85                  90                  95      


Leu Ser Arg Ser Gly Gly Met Val Lys Ser Asn Phe Val Pro Thr Asn 
            100                 105                 110         


Val Gly Ser Lys Ala Phe Gly Arg Arg Arg Arg Asp Leu Gln Ala 
        115                 120                 125         


<210>  1993
<211>  138
<212>  PRT
<213>  Homo Sapiens

<400>  1993

Met Lys Lys Glu Ala Asn Leu Gln Arg Gly Gly Met Gly Phe Arg Lys 
1               5                   10                  15      


Phe Ser Pro Phe Leu Ala Leu Ser Ile Leu Val Leu Tyr Gln Ala Gly 
            20                  25                  30          


Ser Leu Gln Ala Ala Pro Phe Arg Ser Ala Leu Glu Ser Ser Pro Asp 
        35                  40                  45              


Pro Ala Thr Leu Ser Lys Glu Asp Ala Arg Leu Leu Leu Ala Ala Leu 
    50                  55                  60                  


Val Gln Asp Tyr Val Gln Met Lys Ala Ser Glu Leu Lys Gln Glu Gln 
65                  70                  75                  80  


Glu Thr Gln Gly Ser Ser Ser Ala Ala Gln Lys Arg Ala Cys Asn Thr 
                85                  90                  95      


Ala Thr Cys Val Thr His Arg Leu Ala Gly Leu Leu Ser Arg Ser Gly 
            100                 105                 110         


Gly Met Val Lys Ser Asn Phe Val Pro Thr Asn Val Gly Ser Lys Ala 
        115                 120                 125             


Phe Gly Arg Arg Arg Arg Asp Leu Gln Ala 
    130                 135             


<210>  1994
<211>  508
<212>  PRT
<213>  Homo Sapiens

<400>  1994

Met Gln Phe Ser Gly Glu Lys Ile Ser Gly Gln Arg Asp Leu Gln Lys 
1               5                   10                  15      


Ser Lys Met Arg Phe Thr Phe Thr Ser Arg Cys Leu Ala Leu Phe Leu 
            20                  25                  30          


Leu Leu Asn His Pro Thr Pro Ile Leu Pro Ala Phe Ser Asn Gln Thr 
        35                  40                  45              


Tyr Pro Thr Ile Glu Pro Lys Pro Phe Leu Tyr Val Val Gly Arg Lys 
    50                  55                  60                  


Lys Met Met Asp Ala Gln Tyr Lys Cys Tyr Asp Arg Met Gln Gln Leu 
65                  70                  75                  80  


Pro Ala Tyr Gln Gly Glu Gly Pro Tyr Cys Asn Arg Thr Trp Asp Gly 
                85                  90                  95      


Trp Leu Cys Trp Asp Asp Thr Pro Ala Gly Val Leu Ser Tyr Gln Phe 
            100                 105                 110         


Cys Pro Asp Tyr Phe Pro Asp Phe Asp Pro Ser Glu Lys Val Thr Lys 
        115                 120                 125             


Tyr Cys Asp Glu Lys Gly Val Trp Phe Lys His Pro Glu Asn Asn Arg 
    130                 135                 140                 


Thr Trp Ser Asn Tyr Thr Met Cys Asn Ala Phe Thr Pro Glu Lys Leu 
145                 150                 155                 160 


Lys Asn Ala Tyr Val Leu Tyr Tyr Leu Ala Ile Val Gly His Ser Leu 
                165                 170                 175     


Ser Ile Phe Thr Leu Val Ile Ser Leu Gly Ile Phe Val Phe Phe Arg 
            180                 185                 190         


Lys Leu Thr Thr Ile Phe Pro Leu Asn Trp Lys Tyr Arg Lys Ala Leu 
        195                 200                 205             


Ser Leu Gly Cys Gln Arg Val Thr Leu His Lys Asn Met Phe Leu Thr 
    210                 215                 220                 


Tyr Ile Leu Asn Ser Met Ile Ile Ile Ile His Leu Val Glu Val Val 
225                 230                 235                 240 


Pro Asn Gly Glu Leu Val Arg Arg Asp Pro Val Ser Cys Lys Ile Leu 
                245                 250                 255     


His Phe Phe His Gln Tyr Met Met Ala Cys Asn Tyr Phe Trp Met Leu 
            260                 265                 270         


Cys Glu Gly Ile Tyr Leu His Thr Leu Ile Val Val Ala Val Phe Thr 
        275                 280                 285             


Glu Lys Gln Arg Leu Arg Trp Tyr Tyr Leu Leu Gly Trp Gly Phe Pro 
    290                 295                 300                 


Leu Val Pro Thr Thr Ile His Ala Ile Thr Arg Ala Val Tyr Phe Asn 
305                 310                 315                 320 


Asp Asn Cys Trp Leu Ser Val Glu Thr His Leu Leu Tyr Ile Ile His 
                325                 330                 335     


Gly Pro Val Met Ala Ala Leu Val Val Asn Phe Phe Phe Leu Leu Asn 
            340                 345                 350         


Ile Val Arg Val Leu Val Thr Lys Met Arg Glu Thr His Glu Ala Glu 
        355                 360                 365             


Ser His Met Tyr Leu Lys Ala Val Lys Ala Thr Met Ile Leu Val Pro 
    370                 375                 380                 


Leu Leu Gly Ile Gln Phe Val Val Phe Pro Trp Arg Pro Ser Asn Lys 
385                 390                 395                 400 


Met Leu Gly Lys Ile Tyr Asp Tyr Val Met His Ser Leu Ile His Phe 
                405                 410                 415     


Gln Gly Phe Phe Val Ala Thr Ile Tyr Cys Phe Cys Asn Asn Glu Val 
            420                 425                 430         


Gln Thr Thr Val Lys Arg Gln Trp Ala Gln Phe Lys Ile Gln Trp Asn 
        435                 440                 445             


Gln Arg Trp Gly Arg Arg Pro Ser Asn Arg Ser Ala Arg Ala Ala Ala 
    450                 455                 460                 


Ala Ala Ala Glu Ala Gly Asp Ile Pro Ile Tyr Ile Cys His Gln Glu 
465                 470                 475                 480 


Leu Arg Asn Glu Pro Ala Asn Asn Gln Gly Glu Glu Ser Ala Glu Ile 
                485                 490                 495     


Ile Pro Leu Asn Ile Ile Glu Gln Glu Ser Ser Ala 
            500                 505             


<210>  1995
<211>  162
<212>  PRT
<213>  Homo Sapiens

<400>  1995

Met Arg Phe Thr Phe Thr Ser Arg Cys Leu Ala Leu Phe Leu Leu Leu 
1               5                   10                  15      


Asn His Pro Thr Pro Ile Leu Pro Ala Phe Ser Asn Gln Thr Tyr Pro 
            20                  25                  30          


Thr Ile Glu Pro Lys Pro Phe Leu Tyr Val Val Gly Arg Lys Lys Met 
        35                  40                  45              


Met Asp Ala Gln Tyr Lys Cys Tyr Asp Arg Met Gln Gln Leu Pro Ala 
    50                  55                  60                  


Tyr Gln Gly Glu Gly Pro Tyr Cys Asn Arg Thr Trp Asp Gly Trp Leu 
65                  70                  75                  80  


Cys Trp Asp Asp Thr Pro Ala Gly Val Leu Ser Tyr Gln Phe Cys Pro 
                85                  90                  95      


Asp Tyr Phe Pro Asp Phe Asp Pro Ser Glu Lys Val Thr Lys Tyr Cys 
            100                 105                 110         


Asp Glu Lys Gly Val Trp Phe Lys His Pro Glu Asn Asn Arg Thr Trp 
        115                 120                 125             


Ser Asn Tyr Thr Met Cys Asn Ala Phe Thr Pro Glu Lys Leu Lys Asn 
    130                 135                 140                 


Ala Tyr Val Leu Tyr Tyr Leu Ala Ile Val Gly His Ser Cys Gln Phe 
145                 150                 155                 160 


Ser Pro 
        


<210>  1996
<211>  290
<212>  PRT
<213>  Homo Sapiens

<400>  1996

Met Arg Phe Thr Phe Thr Ser Arg Cys Leu Ala Leu Phe Leu Leu Leu 
1               5                   10                  15      


Asn His Pro Thr Pro Ile Leu Pro Ala Phe Ser Asn Gln Thr Tyr Pro 
            20                  25                  30          


Thr Ile Glu Pro Lys Pro Phe Leu Tyr Val Val Gly Arg Lys Lys Met 
        35                  40                  45              


Met Asp Ala Gln Tyr Lys Cys Tyr Asp Arg Met Gln Gln Leu Pro Ala 
    50                  55                  60                  


Tyr Gln Gly Glu Gly Pro Tyr Cys Asn Arg Thr Trp Asp Gly Trp Leu 
65                  70                  75                  80  


Cys Trp Asp Asp Thr Pro Ala Gly Val Leu Ser Tyr Gln Phe Cys Pro 
                85                  90                  95      


Asp Tyr Phe Pro Asp Phe Asp Pro Ser Glu Lys Val Thr Lys Tyr Cys 
            100                 105                 110         


Asp Glu Lys Gly Val Trp Phe Lys His Pro Glu Asn Asn Arg Thr Trp 
        115                 120                 125             


Ser Asn Tyr Thr Met Cys Asn Ala Phe Thr Pro Glu Lys Leu Lys Asn 
    130                 135                 140                 


Ala Tyr Val Leu Tyr Tyr Leu Ala Ile Val Gly His Ser Leu Ser Ile 
145                 150                 155                 160 


Phe Thr Leu Val Ile Ser Leu Gly Ile Phe Val Phe Phe Arg Lys Leu 
                165                 170                 175     


Thr Thr Ile Phe Pro Leu Asn Trp Lys Tyr Arg Lys Ala Leu Ser Leu 
            180                 185                 190         


Gly Cys Gln Arg Val Thr Leu His Lys Asn Met Phe Leu Thr Tyr Ile 
        195                 200                 205             


Leu Asn Ser Met Ile Ile Ile Ile His Leu Val Glu Val Val Pro Asn 
    210                 215                 220                 


Gly Glu Leu Val Arg Arg Asp Pro Val Ser Cys Lys Ile Leu His Phe 
225                 230                 235                 240 


Phe His Gln Tyr Met Met Ala Cys Asn Tyr Phe Trp Met Leu Cys Glu 
                245                 250                 255     


Gly Ile Tyr Leu His Thr Leu Ile Val Val Ala Val Phe Thr Glu Lys 
            260                 265                 270         


Gln Arg Leu Arg Trp Tyr Tyr Leu Leu Gly Trp Ala Pro Ala Phe His 
        275                 280                 285             


Arg Asp 
    290 


<210>  1997
<211>  490
<212>  PRT
<213>  Homo Sapiens

<400>  1997

Met Arg Phe Thr Phe Thr Ser Arg Cys Leu Ala Leu Phe Leu Leu Leu 
1               5                   10                  15      


Asn His Pro Thr Pro Ile Leu Pro Ala Phe Ser Asn Gln Thr Tyr Pro 
            20                  25                  30          


Thr Ile Glu Pro Lys Pro Phe Leu Tyr Val Val Gly Arg Lys Lys Met 
        35                  40                  45              


Met Asp Ala Gln Tyr Lys Cys Tyr Asp Arg Met Gln Gln Leu Pro Ala 
    50                  55                  60                  


Tyr Gln Gly Glu Gly Pro Tyr Cys Asn Arg Thr Trp Asp Gly Trp Leu 
65                  70                  75                  80  


Cys Trp Asp Asp Thr Pro Ala Gly Val Leu Ser Tyr Gln Phe Cys Pro 
                85                  90                  95      


Asp Tyr Phe Pro Asp Phe Asp Pro Ser Glu Lys Val Thr Lys Tyr Cys 
            100                 105                 110         


Asp Glu Lys Gly Val Trp Phe Lys His Pro Glu Asn Asn Arg Thr Trp 
        115                 120                 125             


Ser Asn Tyr Thr Met Cys Asn Ala Phe Thr Pro Glu Lys Leu Lys Asn 
    130                 135                 140                 


Ala Tyr Val Leu Tyr Tyr Leu Ala Ile Val Gly His Ser Leu Ser Ile 
145                 150                 155                 160 


Phe Thr Leu Val Ile Ser Leu Gly Ile Phe Val Phe Phe Arg Lys Leu 
                165                 170                 175     


Thr Thr Ile Phe Pro Leu Asn Trp Lys Tyr Arg Lys Ala Leu Ser Leu 
            180                 185                 190         


Gly Cys Gln Arg Val Thr Leu His Lys Asn Met Phe Leu Thr Tyr Ile 
        195                 200                 205             


Leu Asn Ser Met Ile Ile Ile Ile His Leu Val Glu Val Val Pro Asn 
    210                 215                 220                 


Gly Glu Leu Val Arg Arg Asp Pro Val Ser Cys Lys Ile Leu His Phe 
225                 230                 235                 240 


Phe His Gln Tyr Met Met Ala Cys Asn Tyr Phe Trp Met Leu Cys Glu 
                245                 250                 255     


Gly Ile Tyr Leu His Thr Leu Ile Val Val Ala Val Phe Thr Glu Lys 
            260                 265                 270         


Gln Arg Leu Arg Trp Tyr Tyr Leu Leu Gly Trp Gly Phe Pro Leu Val 
        275                 280                 285             


Pro Thr Thr Ile His Ala Ile Thr Arg Ala Val Tyr Phe Asn Asp Asn 
    290                 295                 300                 


Cys Trp Leu Ser Val Glu Thr His Leu Leu Tyr Ile Ile His Gly Pro 
305                 310                 315                 320 


Val Met Ala Ala Leu Val Val Asn Phe Phe Phe Leu Leu Asn Ile Val 
                325                 330                 335     


Arg Val Leu Val Thr Lys Met Arg Glu Thr His Glu Ala Glu Ser His 
            340                 345                 350         


Met Tyr Leu Lys Ala Val Lys Ala Thr Met Ile Leu Val Pro Leu Leu 
        355                 360                 365             


Gly Ile Gln Phe Val Val Phe Pro Trp Arg Pro Ser Asn Lys Met Leu 
    370                 375                 380                 


Gly Lys Ile Tyr Asp Tyr Val Met His Ser Leu Ile His Phe Gln Gly 
385                 390                 395                 400 


Phe Phe Val Ala Thr Ile Tyr Cys Phe Cys Asn Asn Glu Val Gln Thr 
                405                 410                 415     


Thr Val Lys Arg Gln Trp Ala Gln Phe Lys Ile Gln Trp Asn Gln Arg 
            420                 425                 430         


Trp Gly Arg Arg Pro Ser Asn Arg Ser Ala Arg Ala Ala Ala Ala Ala 
        435                 440                 445             


Ala Glu Ala Gly Asp Ile Pro Ile Tyr Ile Cys His Gln Glu Leu Arg 
    450                 455                 460                 


Asn Glu Pro Ala Asn Asn Gln Gly Glu Glu Ser Ala Glu Ile Ile Pro 
465                 470                 475                 480 


Leu Asn Ile Ile Glu Gln Glu Ser Ser Ala 
                485                 490 


<210>  1998
<211>  474
<212>  PRT
<213>  Homo Sapiens

<400>  1998

Met Arg Phe Thr Phe Thr Ser Arg Cys Leu Ala Leu Phe Leu Leu Leu 
1               5                   10                  15      


Asn His Pro Thr Pro Ile Leu Pro Ala Phe Ser Asn Gln Thr Tyr Pro 
            20                  25                  30          


Thr Ile Glu Pro Lys Pro Phe Leu Tyr Val Val Gly Arg Lys Lys Met 
        35                  40                  45              


Met Asp Ala Gln Tyr Lys Cys Tyr Asp Arg Met Gln Gln Leu Pro Ala 
    50                  55                  60                  


Tyr Gln Gly Glu Gly Pro Tyr Cys Asn Arg Thr Trp Asp Gly Trp Leu 
65                  70                  75                  80  


Cys Trp Asp Asp Thr Pro Ala Gly Val Leu Ser Tyr Gln Phe Cys Pro 
                85                  90                  95      


Asp Tyr Phe Pro Asp Phe Asp Pro Ser Glu Lys Val Thr Lys Tyr Cys 
            100                 105                 110         


Asp Glu Lys Gly Val Trp Phe Lys His Pro Glu Asn Asn Arg Thr Trp 
        115                 120                 125             


Ser Asn Tyr Thr Met Cys Asn Ala Phe Thr Pro Glu Lys Leu Lys Asn 
    130                 135                 140                 


Ala Tyr Val Leu Tyr Tyr Leu Ala Ile Val Gly His Ser Leu Ser Ile 
145                 150                 155                 160 


Phe Thr Leu Val Ile Ser Leu Gly Ile Phe Val Phe Phe Arg Ser Leu 
                165                 170                 175     


Gly Cys Gln Arg Val Thr Leu His Lys Asn Met Phe Leu Thr Tyr Ile 
            180                 185                 190         


Leu Asn Ser Met Ile Ile Ile Ile His Leu Val Glu Val Val Pro Asn 
        195                 200                 205             


Gly Glu Leu Val Arg Arg Asp Pro Val Ser Cys Lys Ile Leu His Phe 
    210                 215                 220                 


Phe His Gln Tyr Met Met Ala Cys Asn Tyr Phe Trp Met Leu Cys Glu 
225                 230                 235                 240 


Gly Ile Tyr Leu His Thr Leu Ile Val Val Ala Val Phe Thr Glu Lys 
                245                 250                 255     


Gln Arg Leu Arg Trp Tyr Tyr Leu Leu Gly Trp Gly Phe Pro Leu Val 
            260                 265                 270         


Pro Thr Thr Ile His Ala Ile Thr Arg Ala Val Tyr Phe Asn Asp Asn 
        275                 280                 285             


Cys Trp Leu Ser Val Glu Thr His Leu Leu Tyr Ile Ile His Gly Pro 
    290                 295                 300                 


Val Met Ala Ala Leu Val Val Asn Phe Phe Phe Leu Leu Asn Ile Val 
305                 310                 315                 320 


Arg Val Leu Val Thr Lys Met Arg Glu Thr His Glu Ala Glu Ser His 
                325                 330                 335     


Met Tyr Leu Lys Ala Val Lys Ala Thr Met Ile Leu Val Pro Leu Leu 
            340                 345                 350         


Gly Ile Gln Phe Val Val Phe Pro Trp Arg Pro Ser Asn Lys Met Leu 
        355                 360                 365             


Gly Lys Ile Tyr Asp Tyr Val Met His Ser Leu Ile His Phe Gln Gly 
    370                 375                 380                 


Phe Phe Val Ala Thr Ile Tyr Cys Phe Cys Asn Asn Glu Val Gln Thr 
385                 390                 395                 400 


Thr Val Lys Arg Gln Trp Ala Gln Phe Lys Ile Gln Trp Asn Gln Arg 
                405                 410                 415     


Trp Gly Arg Arg Pro Ser Asn Arg Ser Ala Arg Ala Ala Ala Ala Ala 
            420                 425                 430         


Ala Glu Ala Gly Asp Ile Pro Ile Tyr Ile Cys His Gln Glu Leu Arg 
        435                 440                 445             


Asn Glu Pro Ala Asn Asn Gln Gly Glu Glu Ser Ala Glu Ile Ile Pro 
    450                 455                 460                 


Leu Asn Ile Ile Glu Gln Glu Ser Ser Ala 
465                 470                 


<210>  1999
<211>  474
<212>  PRT
<213>  Homo Sapiens

<400>  1999

Met Arg Phe Thr Phe Thr Ser Arg Cys Leu Ala Leu Phe Leu Leu Leu 
1               5                   10                  15      


Asn His Pro Thr Pro Ile Leu Pro Ala Phe Ser Asn Gln Thr Tyr Pro 
            20                  25                  30          


Thr Ile Glu Pro Lys Pro Phe Leu Tyr Val Val Gly Arg Lys Lys Met 
        35                  40                  45              


Met Asp Ala Gln Tyr Lys Cys Tyr Asp Arg Met Gln Gln Leu Pro Ala 
    50                  55                  60                  


Tyr Gln Gly Glu Gly Pro Tyr Cys Asn Arg Thr Trp Asp Gly Trp Leu 
65                  70                  75                  80  


Cys Trp Asp Asp Thr Pro Ala Gly Val Leu Ser Tyr Gln Phe Cys Pro 
                85                  90                  95      


Asp Tyr Phe Pro Asp Phe Asp Pro Ser Glu Lys Val Thr Lys Tyr Cys 
            100                 105                 110         


Asp Glu Lys Gly Val Trp Phe Lys His Pro Glu Asn Asn Arg Thr Trp 
        115                 120                 125             


Ser Asn Tyr Thr Met Cys Asn Ala Phe Thr Pro Glu Lys Leu Lys Asn 
    130                 135                 140                 


Ala Tyr Val Leu Tyr Tyr Leu Ala Ile Val Gly His Ser Leu Ser Ile 
145                 150                 155                 160 


Phe Thr Leu Val Ile Ser Leu Gly Ile Phe Val Phe Phe Arg Ser Leu 
                165                 170                 175     


Gly Cys Gln Arg Val Thr Leu His Lys Asn Met Phe Leu Thr Tyr Ile 
            180                 185                 190         


Leu Asn Ser Met Ile Ile Ile Ile His Leu Val Glu Val Val Pro Asn 
        195                 200                 205             


Gly Glu Leu Val Arg Arg Asp Pro Val Ser Cys Lys Ile Leu His Phe 
    210                 215                 220                 


Phe His Gln Tyr Met Met Ala Cys Asn Tyr Phe Trp Met Leu Cys Glu 
225                 230                 235                 240 


Gly Ile Tyr Leu His Thr Leu Ile Val Val Ala Val Phe Thr Glu Lys 
                245                 250                 255     


Gln Arg Leu Arg Trp Tyr Tyr Leu Leu Gly Trp Gly Phe Pro Leu Val 
            260                 265                 270         


Pro Thr Thr Ile His Ala Ile Thr Arg Ala Val Tyr Phe Asn Asp Asn 
        275                 280                 285             


Cys Trp Leu Ser Val Glu Thr His Leu Leu Tyr Ile Ile His Gly Pro 
    290                 295                 300                 


Val Met Ala Ala Leu Val Val Asn Phe Phe Phe Leu Leu Asn Ile Val 
305                 310                 315                 320 


Arg Val Leu Val Thr Lys Met Arg Glu Thr His Glu Ala Glu Ser His 
                325                 330                 335     


Met Tyr Leu Lys Ala Val Lys Ala Thr Met Ile Leu Val Pro Leu Leu 
            340                 345                 350         


Gly Ile Gln Phe Val Val Phe Pro Trp Arg Pro Ser Asn Lys Met Leu 
        355                 360                 365             


Gly Lys Ile Tyr Asp Tyr Val Met His Ser Leu Ile His Phe Gln Gly 
    370                 375                 380                 


Phe Phe Val Ala Thr Ile Tyr Cys Phe Cys Asn Asn Glu Val Gln Thr 
385                 390                 395                 400 


Thr Val Lys Arg Gln Trp Ala Gln Phe Lys Ile Gln Trp Asn Gln Arg 
                405                 410                 415     


Trp Gly Arg Arg Pro Ser Asn Arg Ser Ala Arg Ala Ala Ala Ala Ala 
            420                 425                 430         


Ala Glu Ala Gly Asp Ile Pro Ile Tyr Ile Cys His Gln Glu Leu Arg 
        435                 440                 445             


Asn Glu Pro Ala Asn Asn Gln Gly Glu Glu Ser Ala Glu Ile Ile Pro 
    450                 455                 460                 


Leu Asn Ile Ile Glu Gln Glu Ser Ser Ala 
465                 470                 


<210>  2000
<211>  274
<212>  PRT
<213>  Homo Sapiens

<400>  2000

Met Arg Phe Thr Phe Thr Ser Arg Cys Leu Ala Leu Phe Leu Leu Leu 
1               5                   10                  15      


Asn His Pro Thr Pro Ile Leu Pro Ala Phe Ser Asn Gln Thr Tyr Pro 
            20                  25                  30          


Thr Ile Glu Pro Lys Pro Phe Leu Tyr Val Val Gly Arg Lys Lys Met 
        35                  40                  45              


Met Asp Ala Gln Tyr Lys Cys Tyr Asp Arg Met Gln Gln Leu Pro Ala 
    50                  55                  60                  


Tyr Gln Gly Glu Gly Pro Tyr Cys Asn Arg Thr Trp Asp Gly Trp Leu 
65                  70                  75                  80  


Cys Trp Asp Asp Thr Pro Ala Gly Val Leu Ser Tyr Gln Phe Cys Pro 
                85                  90                  95      


Asp Tyr Phe Pro Asp Phe Asp Pro Ser Glu Lys Val Thr Lys Tyr Cys 
            100                 105                 110         


Asp Glu Lys Gly Val Trp Phe Lys His Pro Glu Asn Asn Arg Thr Trp 
        115                 120                 125             


Ser Asn Tyr Thr Met Cys Asn Ala Phe Thr Pro Glu Lys Leu Lys Asn 
    130                 135                 140                 


Ala Tyr Val Leu Tyr Tyr Leu Ala Ile Val Gly His Ser Leu Ser Ile 
145                 150                 155                 160 


Phe Thr Leu Val Ile Ser Leu Gly Ile Phe Val Phe Phe Arg Ser Leu 
                165                 170                 175     


Gly Cys Gln Arg Val Thr Leu His Lys Asn Met Phe Leu Thr Tyr Ile 
            180                 185                 190         


Leu Asn Ser Met Ile Ile Ile Ile His Leu Val Glu Val Val Pro Asn 
        195                 200                 205             


Gly Glu Leu Val Arg Arg Asp Pro Val Ser Cys Lys Ile Leu His Phe 
    210                 215                 220                 


Phe His Gln Tyr Met Met Ala Cys Asn Tyr Phe Trp Met Leu Cys Glu 
225                 230                 235                 240 


Gly Ile Tyr Leu His Thr Leu Ile Val Val Ala Val Phe Thr Glu Lys 
                245                 250                 255     


Gln Arg Leu Arg Trp Tyr Tyr Leu Leu Gly Trp Ala Pro Ala Phe His 
            260                 265                 270         


Arg Asp 
        


<210>  2001
<211>  37
<212>  PRT
<213>  Homo Sapiens

<400>  2001

Met Glu Lys Lys Cys Thr Leu Tyr Phe Leu Val Leu Leu Pro Phe Phe 
1               5                   10                  15      


Met Ile Leu Val Thr Ala Glu Leu Glu Glu Ser Pro Glu Asp Ser Ile 
            20                  25                  30          


Gln Leu Gly Val Thr 
        35          


<210>  2002
<211>  78
<212>  PRT
<213>  Homo Sapiens

<400>  2002

Met Glu Lys Lys Cys Thr Leu Tyr Phe Leu Val Leu Leu Pro Phe Phe 
1               5                   10                  15      


Met Ile Leu Val Thr Ala Glu Leu Glu Glu Ser Pro Glu Asp Ser Ile 
            20                  25                  30          


Gln Leu Gly Val Thr Arg Asn Lys Ile Met Thr Ala Gln Tyr Glu Cys 
        35                  40                  45              


Tyr Gln Lys Ile Met Gln Asp Pro Ile Gln Gln Ala Glu Gly Val Tyr 
    50                  55                  60                  


Cys Asn Arg Thr Trp Asp Gly Trp Leu Cys Trp Asn Asp Val 
65                  70                  75              


<210>  2003
<211>  461
<212>  PRT
<213>  Homo Sapiens

<400>  2003

Met Glu Lys Lys Cys Thr Leu Tyr Phe Leu Val Leu Leu Pro Phe Phe 
1               5                   10                  15      


Met Ile Leu Val Thr Ala Glu Leu Glu Glu Ser Pro Glu Asp Ser Ile 
            20                  25                  30          


Gln Leu Gly Val Thr Arg Asn Lys Ile Met Thr Ala Gln Tyr Glu Cys 
        35                  40                  45              


Tyr Gln Lys Ile Met Gln Asp Pro Ile Gln Gln Ala Glu Gly Val Tyr 
    50                  55                  60                  


Cys Asn Arg Thr Trp Asp Gly Trp Leu Cys Trp Asn Asp Val Ala Ala 
65                  70                  75                  80  


Gly Thr Glu Ser Met Gln Leu Cys Pro Asp Tyr Phe Gln Asp Phe Asp 
                85                  90                  95      


Pro Ser Glu Lys Val Thr Lys Ile Cys Asp Gln Asp Gly Asn Trp Phe 
            100                 105                 110         


Arg His Pro Ala Ser Asn Arg Thr Trp Thr Asn Tyr Thr Gln Cys Asn 
        115                 120                 125             


Val Asn Thr His Glu Lys Val Lys Thr Ala Leu Asn Leu Phe Tyr Leu 
    130                 135                 140                 


Thr Ile Ile Gly His Gly Leu Ser Ile Ala Ser Leu Leu Ile Ser Leu 
145                 150                 155                 160 


Gly Ile Phe Phe Tyr Phe Lys Ser Leu Ser Cys Gln Arg Ile Thr Leu 
                165                 170                 175     


His Lys Asn Leu Phe Phe Ser Phe Val Cys Asn Ser Val Val Thr Ile 
            180                 185                 190         


Ile His Leu Thr Ala Val Ala Asn Asn Gln Ala Leu Val Ala Thr Asn 
        195                 200                 205             


Pro Val Ser Cys Lys Val Ser Gln Phe Ile His Leu Tyr Leu Met Gly 
    210                 215                 220                 


Cys Asn Tyr Phe Trp Met Leu Cys Glu Gly Ile Tyr Leu His Thr Leu 
225                 230                 235                 240 


Ile Val Val Ala Val Phe Ala Glu Lys Gln His Leu Met Trp Tyr Tyr 
                245                 250                 255     


Phe Leu Gly Trp Gly Phe Pro Leu Ile Pro Ala Cys Ile His Ala Ile 
            260                 265                 270         


Ala Arg Ser Leu Tyr Tyr Asn Asp Asn Cys Trp Ile Ser Ser Asp Thr 
        275                 280                 285             


His Leu Leu Tyr Ile Ile His Gly Pro Ile Cys Ala Ala Leu Leu Val 
    290                 295                 300                 


Asn Leu Phe Phe Leu Leu Asn Ile Val Arg Val Leu Ile Thr Lys Leu 
305                 310                 315                 320 


Lys Val Thr His Gln Ala Glu Ser Asn Leu Tyr Met Lys Ala Val Arg 
                325                 330                 335     


Ala Thr Leu Ile Leu Val Pro Leu Leu Gly Ile Glu Phe Val Leu Ile 
            340                 345                 350         


Pro Trp Arg Pro Glu Gly Lys Ile Ala Glu Glu Val Tyr Asp Tyr Ile 
        355                 360                 365             


Met His Ile Leu Met His Phe Gln Gly Leu Leu Val Ser Thr Ile Phe 
    370                 375                 380                 


Cys Phe Phe Asn Gly Glu Val Gln Ala Ile Leu Arg Arg Asn Trp Asn 
385                 390                 395                 400 


Gln Tyr Lys Ile Gln Phe Gly Asn Ser Phe Ser Asn Ser Glu Ala Leu 
                405                 410                 415     


Arg Ser Ala Ser Tyr Thr Val Ser Thr Ile Ser Asp Gly Pro Gly Tyr 
            420                 425                 430         


Ser His Asp Cys Pro Ser Glu His Leu Asn Gly Lys Ser Ile His Asp 
        435                 440                 445             


Ile Glu Asn Val Leu Leu Lys Pro Glu Asn Leu Tyr Asn 
    450                 455                 460     


<210>  2004
<211>  461
<212>  PRT
<213>  Homo Sapiens

<400>  2004

Met Glu Lys Lys Cys Thr Leu Tyr Phe Leu Val Leu Leu Pro Phe Phe 
1               5                   10                  15      


Met Ile Leu Val Thr Ala Glu Leu Glu Glu Ser Pro Glu Asp Ser Ile 
            20                  25                  30          


Gln Leu Gly Val Thr Arg Asn Lys Ile Met Thr Ala Gln Tyr Glu Cys 
        35                  40                  45              


Tyr Gln Lys Ile Met Gln Asp Pro Ile Gln Gln Ala Glu Gly Val Tyr 
    50                  55                  60                  


Cys Asn Arg Thr Trp Asp Gly Trp Leu Cys Trp Asn Asp Val Ala Ala 
65                  70                  75                  80  


Gly Thr Glu Ser Met Gln Leu Cys Pro Asp Tyr Phe Gln Asp Phe Asp 
                85                  90                  95      


Pro Ser Glu Lys Val Thr Lys Ile Cys Asp Gln Asp Gly Asn Trp Phe 
            100                 105                 110         


Arg His Pro Ala Ser Asn Arg Thr Trp Thr Asn Tyr Thr Gln Cys Asn 
        115                 120                 125             


Val Asn Thr His Glu Lys Val Lys Thr Ala Leu Asn Leu Phe Tyr Leu 
    130                 135                 140                 


Thr Ile Ile Gly His Gly Leu Ser Ile Ala Ser Leu Leu Ile Ser Leu 
145                 150                 155                 160 


Gly Ile Phe Phe Tyr Phe Lys Ser Leu Ser Cys Gln Arg Ile Thr Leu 
                165                 170                 175     


His Lys Asn Leu Phe Phe Ser Phe Val Cys Asn Ser Val Val Thr Ile 
            180                 185                 190         


Ile His Leu Thr Ala Val Ala Asn Asn Gln Ala Leu Val Ala Thr Asn 
        195                 200                 205             


Pro Val Ser Cys Lys Val Ser Gln Phe Ile His Leu Tyr Leu Met Gly 
    210                 215                 220                 


Cys Asn Tyr Phe Trp Met Leu Cys Glu Gly Ile Tyr Leu His Thr Leu 
225                 230                 235                 240 


Ile Val Val Ala Val Phe Ala Glu Lys Gln His Leu Met Trp Tyr Tyr 
                245                 250                 255     


Phe Leu Gly Trp Gly Phe Pro Leu Ile Pro Ala Cys Ile His Ala Ile 
            260                 265                 270         


Ala Arg Ser Leu Tyr Tyr Asn Asp Asn Cys Trp Ile Ser Ser Asp Thr 
        275                 280                 285             


His Leu Leu Tyr Ile Ile His Gly Pro Ile Cys Ala Ala Leu Leu Val 
    290                 295                 300                 


Asn Leu Phe Phe Leu Leu Asn Ile Val Arg Val Leu Ile Thr Lys Leu 
305                 310                 315                 320 


Lys Val Thr His Gln Ala Glu Ser Asn Leu Tyr Met Lys Ala Val Arg 
                325                 330                 335     


Ala Thr Leu Ile Leu Val Pro Leu Leu Gly Ile Glu Phe Val Leu Ile 
            340                 345                 350         


Pro Trp Arg Pro Glu Gly Lys Ile Ala Glu Glu Val Tyr Asp Tyr Ile 
        355                 360                 365             


Met His Ile Leu Met His Phe Gln Gly Leu Leu Val Ser Thr Ile Phe 
    370                 375                 380                 


Cys Phe Phe Asn Gly Glu Val Gln Ala Ile Leu Arg Arg Asn Trp Asn 
385                 390                 395                 400 


Gln Tyr Lys Ile Gln Phe Gly Asn Ser Phe Ser Asn Ser Glu Ala Leu 
                405                 410                 415     


Arg Ser Ala Ser Tyr Thr Val Ser Thr Ile Ser Asp Gly Pro Gly Tyr 
            420                 425                 430         


Ser His Asp Cys Pro Ser Glu His Leu Asn Gly Lys Ser Ile His Asp 
        435                 440                 445             


Ile Glu Asn Val Leu Leu Lys Pro Glu Asn Leu Tyr Asn 
    450                 455                 460     


<210>  2005
<211>  461
<212>  PRT
<213>  Homo Sapiens

<400>  2005

Met Glu Lys Lys Cys Thr Leu Tyr Phe Leu Val Leu Leu Pro Phe Phe 
1               5                   10                  15      


Met Ile Leu Val Thr Ala Glu Leu Glu Glu Ser Pro Glu Asp Ser Ile 
            20                  25                  30          


Gln Leu Gly Val Thr Arg Asn Lys Ile Met Thr Ala Gln Tyr Glu Cys 
        35                  40                  45              


Tyr Gln Lys Ile Met Gln Asp Pro Ile Gln Gln Ala Glu Gly Val Tyr 
    50                  55                  60                  


Cys Asn Arg Thr Trp Asp Gly Trp Leu Cys Trp Asn Asp Val Ala Ala 
65                  70                  75                  80  


Gly Thr Glu Ser Met Gln Leu Cys Pro Asp Tyr Phe Gln Asp Phe Asp 
                85                  90                  95      


Pro Ser Glu Lys Val Thr Lys Ile Cys Asp Gln Asp Gly Asn Trp Phe 
            100                 105                 110         


Arg His Pro Ala Ser Asn Arg Thr Trp Thr Asn Tyr Thr Gln Cys Asn 
        115                 120                 125             


Val Asn Thr His Glu Lys Val Lys Thr Ala Leu Asn Leu Phe Tyr Leu 
    130                 135                 140                 


Thr Ile Ile Gly His Gly Leu Ser Ile Ala Ser Leu Leu Ile Ser Leu 
145                 150                 155                 160 


Gly Ile Phe Phe Tyr Phe Lys Ser Leu Ser Cys Gln Arg Ile Thr Leu 
                165                 170                 175     


His Lys Asn Leu Phe Phe Ser Phe Val Cys Asn Ser Val Val Thr Ile 
            180                 185                 190         


Ile His Leu Thr Ala Val Ala Asn Asn Gln Ala Leu Val Ala Thr Asn 
        195                 200                 205             


Pro Val Ser Cys Lys Val Ser Gln Phe Ile His Leu Tyr Leu Met Gly 
    210                 215                 220                 


Cys Asn Tyr Phe Trp Met Leu Cys Glu Gly Ile Tyr Leu His Thr Leu 
225                 230                 235                 240 


Ile Val Val Ala Val Phe Ala Glu Lys Gln His Leu Met Trp Tyr Tyr 
                245                 250                 255     


Phe Leu Gly Trp Gly Phe Pro Leu Ile Pro Ala Cys Ile His Ala Ile 
            260                 265                 270         


Ala Arg Ser Leu Tyr Tyr Asn Asp Asn Cys Trp Ile Ser Ser Asp Thr 
        275                 280                 285             


His Leu Leu Tyr Ile Ile His Gly Pro Ile Cys Ala Ala Leu Leu Val 
    290                 295                 300                 


Asn Leu Phe Phe Leu Leu Asn Ile Val Arg Val Leu Ile Thr Lys Leu 
305                 310                 315                 320 


Lys Val Thr His Gln Ala Glu Ser Asn Leu Tyr Met Lys Ala Val Arg 
                325                 330                 335     


Ala Thr Leu Ile Leu Val Pro Leu Leu Gly Ile Glu Phe Val Leu Ile 
            340                 345                 350         


Pro Trp Arg Pro Glu Gly Lys Ile Ala Glu Glu Val Tyr Asp Tyr Ile 
        355                 360                 365             


Met His Ile Leu Met His Phe Gln Gly Leu Leu Val Ser Thr Ile Phe 
    370                 375                 380                 


Cys Phe Phe Asn Gly Glu Val Gln Ala Ile Leu Arg Arg Asn Trp Asn 
385                 390                 395                 400 


Gln Tyr Lys Ile Gln Phe Gly Asn Ser Phe Ser Asn Ser Glu Ala Leu 
                405                 410                 415     


Arg Ser Ala Ser Tyr Thr Val Ser Thr Ile Ser Asp Gly Pro Gly Tyr 
            420                 425                 430         


Ser His Asp Cys Pro Ser Glu His Leu Asn Gly Lys Ser Ile His Asp 
        435                 440                 445             


Ile Glu Asn Val Leu Leu Lys Pro Glu Asn Leu Tyr Asn 
    450                 455                 460     


<210>  2006
<211>  170
<212>  PRT
<213>  Homo Sapiens

<400>  2006

Met Ala Pro Arg Ser Ala Lys Glu Thr Phe Arg Ile Asn Pro Asn Val 
1               5                   10                  15      


Ala Ala Asn Leu Ser Ala Pro Ser Asp Val Ile Leu Val Arg Asp Glu 
            20                  25                  30          


Ile Ala Leu Leu His Arg Tyr Gln Ser Gln Met Leu Gly Trp Ile Leu 
        35                  40                  45              


Ile Thr Leu Ala Thr Ile Ala Ala Leu Val Ser Cys Cys Val Ala Lys 
    50                  55                  60                  


Cys Cys Ser Pro Leu Thr Ser Leu Gln His Cys Tyr Trp Thr Ser His 
65                  70                  75                  80  


Leu Gln Asn Glu Arg Glu Leu Phe Glu Gln Ala Ala Glu Gln His Ser 
                85                  90                  95      


Arg Leu Leu Met Met His Arg Ile Lys Lys Leu Phe Gly Phe Ile Pro 
            100                 105                 110         


Gly Ser Glu Asp Val Lys His Ile Arg Ile Pro Ser Cys Gln Asp Trp 
        115                 120                 125             


Lys Asp Ile Ser Val Pro Thr Leu Leu Cys Met Gly Asp Asp Leu Gln 
    130                 135                 140                 


Gly His Tyr Ser Phe Leu Gly Asn Arg Val Asp Glu Asp Asn Glu Glu 
145                 150                 155                 160 


Asp Arg Ser Arg Gly Ile Glu Leu Lys Pro 
                165                 170 


<210>  2007
<211>  314
<212>  PRT
<213>  Homo Sapiens

<400>  2007

Met Cys Pro Thr Leu Asn Asn Ile Val Ser Ser Leu Gln Arg Asn Gly 
1               5                   10                  15      


Ile Phe Ile Asn Ser Leu Ile Ala Ala Leu Thr Ile Gly Gly Gln Gln 
            20                  25                  30          


Leu Phe Ser Ser Ser Thr Phe Ser Cys Pro Cys Gln Val Gly Lys Asn 
        35                  40                  45              


Phe Tyr Tyr Gly Ser Ala Phe Leu Val Ile Pro Ala Leu Ile Leu Leu 
    50                  55                  60                  


Val Ala Gly Phe Ala Leu Arg Ser Gln Met Trp Thr Ile Thr Gly Glu 
65                  70                  75                  80  


Tyr Cys Cys Ser Cys Ala Pro Pro Tyr Arg Arg Ile Ser Pro Leu Glu 
                85                  90                  95      


Cys Lys Leu Ala Cys Leu Arg Phe Phe Ser Ile Thr Gly Arg Ala Val 
            100                 105                 110         


Ile Ala Pro Leu Thr Trp Leu Ala Val Thr Leu Leu Thr Gly Thr Tyr 
        115                 120                 125             


Tyr Glu Cys Ala Ala Ser Glu Phe Ala Ser Val Asp His Tyr Pro Met 
    130                 135                 140                 


Phe Asp Asn Val Ser Ala Ser Lys Arg Glu Glu Ile Leu Ala Gly Phe 
145                 150                 155                 160 


Pro Cys Cys Arg Ser Ala Pro Ser Asp Val Ile Leu Val Arg Asp Glu 
                165                 170                 175     


Ile Ala Leu Leu His Arg Tyr Gln Ser Gln Met Leu Gly Trp Ile Leu 
            180                 185                 190         


Ile Thr Leu Ala Thr Ile Ala Ala Leu Val Ser Cys Cys Val Ala Lys 
        195                 200                 205             


Cys Cys Ser Pro Leu Thr Ser Leu Gln His Cys Tyr Trp Thr Ser His 
    210                 215                 220                 


Leu Gln Asn Glu Arg Glu Leu Phe Glu Gln Ala Ala Glu Gln His Ser 
225                 230                 235                 240 


Arg Leu Leu Met Met His Arg Ile Lys Lys Leu Phe Gly Phe Ile Pro 
                245                 250                 255     


Gly Ser Glu Asp Val Lys His Ile Arg Ile Pro Ser Cys Gln Asp Trp 
            260                 265                 270         


Lys Asp Ile Ser Val Pro Thr Leu Leu Cys Met Gly Asp Asp Leu Gln 
        275                 280                 285             


Gly His Tyr Ser Phe Leu Gly Asn Arg Val Asp Glu Asp Asn Glu Glu 
    290                 295                 300                 


Asp Arg Ser Arg Gly Ile Glu Leu Lys Pro 
305                 310                 


<210>  2008
<211>  171
<212>  PRT
<213>  Homo Sapiens

<400>  2008

Met Phe Asp Asn Val Ser Ala Ser Lys Arg Glu Glu Ile Leu Ala Gly 
1               5                   10                  15      


Phe Pro Cys Cys Arg Ser Ala Pro Ser Asp Val Ile Leu Val Arg Asp 
            20                  25                  30          


Glu Ile Ala Leu Leu His Arg Tyr Gln Ser Gln Met Leu Gly Trp Ile 
        35                  40                  45              


Leu Ile Thr Leu Ala Thr Ile Ala Ala Leu Val Ser Cys Cys Val Ala 
    50                  55                  60                  


Lys Cys Cys Ser Pro Leu Thr Ser Leu Gln His Cys Tyr Trp Thr Ser 
65                  70                  75                  80  


His Leu Gln Asn Glu Arg Glu Leu Phe Glu Gln Ala Ala Glu Gln His 
                85                  90                  95      


Ser Arg Leu Leu Met Met His Arg Ile Lys Lys Leu Phe Gly Phe Ile 
            100                 105                 110         


Pro Gly Ser Glu Asp Val Lys His Ile Arg Ile Pro Ser Cys Gln Asp 
        115                 120                 125             


Trp Lys Asp Ile Ser Val Pro Thr Leu Leu Cys Met Gly Asp Asp Leu 
    130                 135                 140                 


Gln Gly His Tyr Ser Phe Leu Gly Asn Arg Val Asp Glu Asp Asn Glu 
145                 150                 155                 160 


Glu Asp Arg Ser Arg Gly Ile Glu Leu Lys Pro 
                165                 170     


<210>  2009
<211>  123
<212>  PRT
<213>  Homo Sapiens

<400>  2009

Met Leu Gly Trp Ile Leu Ile Thr Leu Ala Thr Ile Ala Ala Leu Val 
1               5                   10                  15      


Ser Cys Cys Val Ala Lys Cys Cys Ser Pro Leu Thr Ser Leu Gln His 
            20                  25                  30          


Cys Tyr Trp Thr Ser His Leu Gln Asn Glu Arg Glu Leu Phe Glu Gln 
        35                  40                  45              


Ala Ala Glu Gln His Ser Arg Leu Leu Met Met His Arg Ile Lys Lys 
    50                  55                  60                  


Leu Phe Gly Phe Ile Pro Gly Ser Glu Asp Val Lys His Ile Arg Ile 
65                  70                  75                  80  


Pro Ser Cys Gln Asp Trp Lys Asp Ile Ser Val Pro Thr Leu Leu Cys 
                85                  90                  95      


Met Gly Asp Asp Leu Gln Gly His Tyr Ser Phe Leu Gly Asn Arg Val 
            100                 105                 110         


Asp Glu Asp Asn Glu Glu Asp Arg Ser Arg Gly 
        115                 120             


<210>  2010
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  2010

Met Leu Gly Trp Ile Leu Ile Thr Leu Ala Thr Ile Ala Ala Leu Val 
1               5                   10                  15      


Ser Cys Cys Val Ala Lys Cys Cys Ser Pro Leu Thr Ser Leu Gln His 
            20                  25                  30          


Cys Tyr Trp Thr Ser His Leu Gln Asn Glu Arg Glu Leu Phe Glu Gln 
        35                  40                  45              


Ala Ala Glu Gln His Ser Arg Leu Leu Met Met His Arg Ile Lys Lys 
    50                  55                  60                  


Leu Phe Gly Phe Ile Pro Gly Ser Glu Asp Val Lys His Ile Arg Ile 
65                  70                  75                  80  


Pro Ser Cys Gln Asp Trp Lys Asp Ile Ser Val Pro Thr Leu Leu Cys 
                85                  90                  95      


Met Gly Asp Asp Leu Gln Gly His Tyr Ser Phe Leu Gly Asn Arg Val 
            100                 105                 110         


Asp Glu Asp Asn Glu Glu Asp Arg Ser Arg Gly Ile Glu Leu Lys Pro 
        115                 120                 125             


<210>  2011
<211>  417
<212>  PRT
<213>  Homo Sapiens

<400>  2011

Met Leu Leu Ser Val Pro Leu Leu Leu Gly Leu Leu Gly Leu Ala Val 
1               5                   10                  15      


Ala Glu Pro Ala Val Tyr Phe Lys Glu Gln Phe Leu Asp Gly Asp Gly 
            20                  25                  30          


Trp Thr Ser Arg Trp Ile Glu Ser Lys His Lys Ser Asp Phe Gly Lys 
        35                  40                  45              


Phe Val Leu Ser Ser Gly Lys Phe Tyr Gly Asp Glu Glu Lys Asp Lys 
    50                  55                  60                  


Gly Leu Gln Thr Ser Gln Asp Ala Arg Phe Tyr Ala Leu Ser Ala Ser 
65                  70                  75                  80  


Phe Glu Pro Phe Ser Asn Lys Gly Gln Thr Leu Val Val Gln Phe Thr 
                85                  90                  95      


Val Lys His Glu Gln Asn Ile Asp Cys Gly Gly Gly Tyr Val Lys Leu 
            100                 105                 110         


Phe Pro Asn Ser Leu Asp Gln Thr Asp Met His Gly Asp Ser Glu Tyr 
        115                 120                 125             


Asn Ile Met Phe Gly Pro Asp Ile Cys Gly Pro Gly Thr Lys Lys Val 
    130                 135                 140                 


His Val Ile Phe Asn Tyr Lys Gly Lys Asn Val Leu Ile Asn Lys Asp 
145                 150                 155                 160 


Ile Arg Cys Lys Asp Asp Glu Phe Thr His Leu Tyr Thr Leu Ile Val 
                165                 170                 175     


Arg Pro Asp Asn Thr Tyr Glu Val Lys Ile Asp Asn Ser Gln Val Glu 
            180                 185                 190         


Ser Gly Ser Leu Glu Asp Asp Trp Asp Phe Leu Pro Pro Lys Lys Ile 
        195                 200                 205             


Lys Asp Pro Asp Ala Ser Lys Pro Glu Asp Trp Asp Glu Arg Ala Lys 
    210                 215                 220                 


Ile Asp Asp Pro Thr Asp Ser Lys Pro Glu Asp Trp Asp Lys Pro Glu 
225                 230                 235                 240 


His Ile Pro Asp Pro Asp Ala Lys Lys Pro Glu Asp Trp Asp Glu Glu 
                245                 250                 255     


Met Asp Gly Glu Trp Glu Pro Pro Val Ile Gln Asn Pro Glu Tyr Lys 
            260                 265                 270         


Gly Glu Trp Lys Pro Arg Gln Ile Asp Asn Pro Asp Tyr Lys Gly Thr 
        275                 280                 285             


Trp Ile His Pro Glu Ile Asp Asn Pro Glu Tyr Ser Pro Asp Pro Ser 
    290                 295                 300                 


Ile Tyr Ala Tyr Asp Asn Phe Gly Val Leu Gly Leu Asp Leu Trp Gln 
305                 310                 315                 320 


Val Lys Ser Gly Thr Ile Phe Asp Asn Phe Leu Ile Thr Asn Asp Glu 
                325                 330                 335     


Ala Tyr Ala Glu Glu Phe Gly Asn Glu Thr Trp Gly Val Thr Lys Ala 
            340                 345                 350         


Ala Glu Lys Gln Met Lys Asp Lys Gln Asp Glu Glu Gln Arg Leu Lys 
        355                 360                 365             


Glu Glu Glu Glu Asp Lys Lys Arg Lys Glu Glu Glu Glu Ala Glu Asp 
    370                 375                 380                 


Lys Glu Asp Asp Glu Asp Lys Asp Glu Asp Glu Glu Asp Glu Glu Asp 
385                 390                 395                 400 


Lys Glu Glu Asp Glu Glu Glu Asp Val Pro Gly Gln Ala Lys Asp Glu 
                405                 410                 415     


Leu 
    


<210>  2012
<211>  247
<212>  PRT
<213>  Homo Sapiens

<400>  2012

Met Leu Leu Ser Val Pro Leu Leu Leu Gly Leu Leu Gly Leu Ala Val 
1               5                   10                  15      


Ala Glu Pro Ala Val Tyr Phe Lys Glu Gln Phe Leu Asp Gly Asp Gly 
            20                  25                  30          


Trp Thr Ser Arg Trp Ile Glu Ser Lys His Lys Ser Asp Phe Gly Lys 
        35                  40                  45              


Phe Val Leu Ser Ser Gly Lys Phe Tyr Gly Asp Glu Glu Lys Asp Lys 
    50                  55                  60                  


Gly Pro Asp Ile Cys Gly Pro Gly Thr Lys Lys Val His Val Ile Phe 
65                  70                  75                  80  


Asn Tyr Lys Gly Lys Asn Val Leu Ile Asn Lys Asp Ile Arg Cys Lys 
                85                  90                  95      


Asp Asp Glu Phe Thr His Leu Tyr Thr Leu Ile Val Arg Pro Asp Asn 
            100                 105                 110         


Thr Tyr Glu Val Lys Ile Asp Asn Ser Gln Val Glu Ser Gly Ser Leu 
        115                 120                 125             


Glu Asp Asp Trp Asp Phe Leu Pro Pro Lys Lys Ile Lys Asp Pro Asp 
    130                 135                 140                 


Ala Ser Lys Pro Glu Asp Trp Asp Glu Arg Ala Lys Ile Asp Asp Pro 
145                 150                 155                 160 


Thr Asp Ser Lys Pro Glu Asp Trp Asp Lys Pro Glu His Ile Pro Asp 
                165                 170                 175     


Pro Asp Ala Lys Lys Pro Glu Asp Trp Asp Glu Glu Met Asp Gly Glu 
            180                 185                 190         


Trp Glu Pro Pro Val Ile Gln Asn Pro Glu Tyr Lys Gly Glu Trp Lys 
        195                 200                 205             


Pro Arg Gln Ile Asp Asn Pro Asp Tyr Lys Gly Thr Trp Ile His Pro 
    210                 215                 220                 


Glu Ile Asp Asn Pro Glu Tyr Ser Pro Asp Pro Ser Ile Tyr Ala Tyr 
225                 230                 235                 240 


Asp Asn Phe Gly Val Leu Gly 
                245         


<210>  2013
<211>  163
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2013

Xaa Glu Asp Trp Asp Glu Arg Ala Lys Ile Asp Asp Pro Thr Asp Ser 
1               5                   10                  15      


Lys Pro Glu Asp Trp Asp Lys Pro Glu His Ile Pro Asp Pro Asp Ala 
            20                  25                  30          


Lys Lys Pro Glu Asp Trp Asp Glu Glu Met Asp Gly Glu Trp Glu Pro 
        35                  40                  45              


Pro Val Ile Gln Asn Pro Glu Tyr Lys Gly Glu Trp Lys Pro Arg Gln 
    50                  55                  60                  


Ile Asp Asn Pro Asp Tyr Lys Gly Thr Trp Ile His Pro Glu Ile Asp 
65                  70                  75                  80  


Asn Pro Glu Tyr Ser Pro Asp Pro Ser Ile Tyr Ala Tyr Asp Asn Phe 
                85                  90                  95      


Gly Val Leu Gly Leu Asp Leu Trp Gln Val Lys Ser Gly Thr Ile Phe 
            100                 105                 110         


Asp Asn Phe Leu Ile Thr Asn Asp Glu Ala Tyr Ala Glu Glu Phe Gly 
        115                 120                 125             


Asn Glu Thr Trp Gly Val Thr Lys Ala Ala Glu Lys Gln Met Lys Asp 
    130                 135                 140                 


Lys Gln Asp Glu Glu Gln Arg Pro Glu Arg Ser Cys Arg Arg Ala Gly 
145                 150                 155                 160 


Arg Ala Lys 
            


<210>  2014
<211>  13
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2014

Xaa Glu Glu Asp Val Pro Gly Gln Ala Lys Asp Glu Leu 
1               5                   10              


<210>  2015
<211>  384
<212>  PRT
<213>  Homo Sapiens

<400>  2015

Met Ala Arg Ala Leu Val Gln Leu Trp Ala Ile Cys Met Leu Arg Val 
1               5                   10                  15      


Ala Leu Ala Thr Val Tyr Phe Gln Glu Glu Phe Leu Asp Gly Glu His 
            20                  25                  30          


Trp Arg Asn Arg Trp Leu Gln Ser Thr Asn Asp Ser Arg Phe Gly His 
        35                  40                  45              


Phe Arg Leu Ser Ser Gly Lys Phe Tyr Gly His Lys Glu Lys Asp Lys 
    50                  55                  60                  


Gly Leu Gln Thr Thr Gln Asn Gly Arg Phe Tyr Ala Ile Ser Ala Arg 
65                  70                  75                  80  


Phe Lys Pro Phe Ser Asn Lys Gly Lys Thr Leu Val Ile Gln Tyr Thr 
                85                  90                  95      


Val Lys His Glu Gln Lys Met Asp Cys Gly Gly Gly Tyr Ile Lys Val 
            100                 105                 110         


Phe Pro Ala Asp Ile Asp Gln Lys Asn Leu Asn Gly Lys Ser Gln Tyr 
        115                 120                 125             


Tyr Ile Met Phe Gly Pro Asp Ile Cys Gly Phe Asp Ile Lys Lys Val 
    130                 135                 140                 


His Val Ile Leu His Phe Lys Asn Lys Tyr His Glu Asn Lys Lys Leu 
145                 150                 155                 160 


Ile Arg Cys Lys Val Asp Gly Phe Thr His Leu Tyr Thr Leu Ile Leu 
                165                 170                 175     


Arg Pro Asp Leu Ser Tyr Asp Val Lys Ile Asp Gly Gln Ser Ile Glu 
            180                 185                 190         


Ser Gly Ser Ile Glu Tyr Asp Trp Asn Leu Thr Ser Leu Lys Lys Glu 
        195                 200                 205             


Thr Ser Pro Ala Glu Ser Lys Asp Trp Glu Gln Thr Lys Asp Asn Lys 
    210                 215                 220                 


Ala Gln Asp Trp Glu Lys His Phe Leu Asp Ala Ser Thr Ser Lys Gln 
225                 230                 235                 240 


Ser Asp Trp Asn Gly Asp Leu Asp Gly Asp Trp Pro Ala Pro Met Leu 
                245                 250                 255     


Gln Lys Pro Pro Tyr Gln Asp Gly Leu Lys Pro Glu Gly Ile His Lys 
            260                 265                 270         


Asp Val Trp Leu His Arg Lys Met Lys Asn Thr Asp Tyr Leu Thr Gln 
        275                 280                 285             


Tyr Asp Leu Ser Glu Phe Glu Asn Ile Gly Ala Ile Gly Leu Glu Leu 
    290                 295                 300                 


Trp Gln Val Arg Ser Gly Thr Ile Phe Asp Asn Phe Leu Ile Thr Asp 
305                 310                 315                 320 


Asp Glu Glu Tyr Ala Asp Asn Phe Gly Lys Ala Thr Trp Gly Glu Thr 
                325                 330                 335     


Lys Gly Pro Glu Arg Glu Met Asp Ala Ile Gln Ala Lys Glu Glu Met 
            340                 345                 350         


Lys Lys Ala Arg Glu Glu Glu Glu Glu Glu Leu Leu Ser Gly Lys Ile 
        355                 360                 365             


Asn Arg His Glu His Tyr Phe Asn Gln Phe His Arg Arg Asn Glu Leu 
    370                 375                 380                 


<210>  2016
<211>  142
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2016

Xaa Leu Val Gln Leu Trp Ala Ile Cys Met Leu Arg Val Ala Leu Ala 
1               5                   10                  15      


Thr Val Tyr Phe Gln Glu Glu Phe Leu Asp Gly Glu His Trp Arg Asn 
            20                  25                  30          


Arg Trp Leu Gln Ser Thr Asn Asp Ser Arg Phe Gly His Phe Arg Leu 
        35                  40                  45              


Ser Ser Gly Lys Phe Tyr Gly His Lys Glu Lys Asp Lys Gly Pro Asp 
    50                  55                  60                  


Ile Cys Gly Phe Asp Ile Lys Lys Val His Val Ile Leu His Phe Lys 
65                  70                  75                  80  


Asn Lys Tyr His Glu Asn Lys Lys Leu Ile Arg Cys Lys Val Asp Gly 
                85                  90                  95      


Phe Thr His Leu Tyr Thr Leu Ile Leu Arg Pro Asp Leu Ser Tyr Asp 
            100                 105                 110         


Val Lys Ile Asp Gly Gln Ser Ile Glu Ser Gly Ser Ile Glu Tyr Asp 
        115                 120                 125             


Trp Asn Leu Thr Ser Leu Lys Lys Glu Thr Ser Pro Ala Glu 
    130                 135                 140         


<210>  2017
<211>  315
<212>  PRT
<213>  Homo Sapiens

<400>  2017

Met Asp Leu Arg Gln Phe Leu Met Cys Leu Ser Leu Cys Thr Ala Phe 
1               5                   10                  15      


Ala Leu Ser Lys Pro Thr Glu Lys Lys Asp Arg Val His His Glu Pro 
            20                  25                  30          


Gln Leu Ser Asp Lys Val His Asn Asp Ala Gln Ser Phe Asp Tyr Asp 
        35                  40                  45              


His Asp Ala Phe Leu Gly Ala Glu Glu Ala Lys Thr Phe Asp Gln Leu 
    50                  55                  60                  


Thr Pro Glu Glu Ser Lys Glu Arg Leu Gly Lys Ile Val Ser Lys Ile 
65                  70                  75                  80  


Asp Gly Asp Lys Asp Gly Phe Val Thr Val Asp Glu Leu Lys Asp Trp 
                85                  90                  95      


Ile Lys Phe Ala Gln Lys Arg Trp Ile Tyr Glu Asp Val Glu Arg Gln 
            100                 105                 110         


Trp Lys Gly His Asp Leu Asn Glu Asp Gly Leu Val Ser Trp Glu Glu 
        115                 120                 125             


Tyr Lys Asn Ala Thr Tyr Gly Tyr Val Leu Asp Asp Pro Asp Pro Asp 
    130                 135                 140                 


Asp Gly Phe Asn Tyr Lys Gln Met Met Val Arg Asp Glu Arg Arg Phe 
145                 150                 155                 160 


Lys Met Ala Asp Lys Asp Gly Asp Leu Ile Ala Thr Lys Glu Glu Phe 
                165                 170                 175     


Thr Ala Phe Leu His Pro Glu Glu Tyr Asp Tyr Met Lys Asp Ile Val 
            180                 185                 190         


Val Gln Glu Thr Met Glu Asp Ile Asp Lys Asn Ala Asp Gly Phe Ile 
        195                 200                 205             


Asp Leu Glu Glu Tyr Ile Gly Asp Met Tyr Ser His Asp Gly Asn Thr 
    210                 215                 220                 


Asp Glu Pro Glu Trp Val Lys Thr Glu Arg Glu Gln Phe Val Glu Phe 
225                 230                 235                 240 


Arg Asp Lys Asn Arg Asp Gly Lys Met Asp Lys Glu Glu Thr Lys Asp 
                245                 250                 255     


Trp Ile Leu Pro Ser Asp Tyr Asp His Ala Glu Ala Glu Ala Arg His 
            260                 265                 270         


Leu Val Tyr Glu Ser Asp Gln Asn Lys Asp Gly Lys Leu Thr Lys Glu 
        275                 280                 285             


Glu Ile Val Asp Lys Tyr Asp Leu Phe Val Gly Ser Gln Ala Thr Asp 
    290                 295                 300                 


Phe Gly Glu Ala Leu Val Arg His Asp Glu Phe 
305                 310                 315 


<210>  2018
<211>  224
<212>  PRT
<213>  Homo Sapiens

<400>  2018

Met Asp Leu Arg Gln Phe Leu Met Cys Leu Ser Leu Cys Thr Ala Phe 
1               5                   10                  15      


Ala Leu Ser Lys Pro Thr Glu Lys Lys Asp Arg Val His His Glu Pro 
            20                  25                  30          


Gln Leu Ser Asp Lys Val His Asn Asp Ala Gln Ser Phe Asp Tyr Asp 
        35                  40                  45              


His Asp Ala Phe Leu Gly Ala Glu Glu Ala Lys Thr Phe Asp Gln Leu 
    50                  55                  60                  


Thr Pro Glu Glu Ser Lys Glu Arg Leu Gly Lys Ile Val Ser Lys Ile 
65                  70                  75                  80  


Asp Gly Asp Lys Asp Gly Phe Val Thr Val Asp Glu Leu Lys Asp Trp 
                85                  90                  95      


Ile Lys Phe Ala Gln Lys Arg Trp Ile Tyr Glu Asp Val Glu Arg Gln 
            100                 105                 110         


Trp Lys Gly His Asp Leu Asn Glu Asp Gly Leu Val Ser Trp Glu Glu 
        115                 120                 125             


Tyr Lys Asn Ala Thr Tyr Gly Tyr Val Leu Asp Asp Pro Asp Pro Asp 
    130                 135                 140                 


Asp Gly Phe Asn Tyr Lys Gln Met Met Val Arg Asp Glu Arg Arg Phe 
145                 150                 155                 160 


Lys Met Ala Asp Lys Asp Gly Asp Leu Ile Ala Thr Lys Glu Glu Phe 
                165                 170                 175     


Thr Ala Phe Leu His Pro Glu Glu Tyr Asp Tyr Met Lys Asp Ile Val 
            180                 185                 190         


Val Gln Glu Thr Met Glu Asp Ile Asp Lys Asn Ala Asp Gly Phe Ile 
        195                 200                 205             


Asp Leu Glu Glu Tyr Ile Gly Trp Gln Ala Tyr Gln Gly Gly Asp Arg 
    210                 215                 220                 


<210>  2019
<211>  315
<212>  PRT
<213>  Homo Sapiens

<400>  2019

Met Asp Leu Arg Gln Phe Leu Met Cys Leu Ser Leu Cys Thr Ala Phe 
1               5                   10                  15      


Ala Leu Ser Lys Pro Thr Glu Lys Lys Asp Arg Val His His Glu Pro 
            20                  25                  30          


Gln Leu Ser Asp Lys Val His Asn Asp Ala Gln Ser Phe Asp Tyr Asp 
        35                  40                  45              


His Asp Ala Phe Leu Gly Ala Glu Glu Ala Lys Thr Phe Asp Gln Leu 
    50                  55                  60                  


Thr Pro Glu Glu Ser Lys Glu Arg Leu Gly Met Ile Val Asp Lys Ile 
65                  70                  75                  80  


Asp Ala Asp Lys Asp Gly Phe Val Thr Glu Gly Glu Leu Lys Ser Trp 
                85                  90                  95      


Ile Lys His Ala Gln Lys Lys Tyr Ile Tyr Asp Asn Val Glu Asn Gln 
            100                 105                 110         


Trp Gln Glu Phe Asp Met Asn Gln Asp Gly Leu Ile Ser Trp Asp Glu 
        115                 120                 125             


Tyr Arg Asn Val Thr Tyr Gly Thr Tyr Leu Asp Asp Pro Asp Pro Asp 
    130                 135                 140                 


Asp Gly Phe Asn Tyr Lys Gln Met Met Val Arg Asp Glu Arg Arg Phe 
145                 150                 155                 160 


Lys Met Ala Asp Lys Asp Gly Asp Leu Ile Ala Thr Lys Glu Glu Phe 
                165                 170                 175     


Thr Ala Phe Leu His Pro Glu Glu Tyr Asp Tyr Met Lys Asp Ile Val 
            180                 185                 190         


Val Gln Glu Thr Met Glu Asp Ile Asp Lys Asn Ala Asp Gly Phe Ile 
        195                 200                 205             


Asp Leu Glu Glu Tyr Ile Gly Asp Met Tyr Ser His Asp Gly Asn Thr 
    210                 215                 220                 


Asp Glu Pro Glu Trp Val Lys Thr Glu Arg Glu Gln Phe Val Glu Phe 
225                 230                 235                 240 


Arg Asp Lys Asn Arg Asp Gly Lys Met Asp Lys Glu Glu Thr Lys Asp 
                245                 250                 255     


Trp Ile Leu Pro Ser Asp Tyr Asp His Ala Glu Ala Glu Ala Arg His 
            260                 265                 270         


Leu Val Tyr Glu Ser Asp Gln Asn Lys Asp Gly Lys Leu Thr Lys Glu 
        275                 280                 285             


Glu Ile Val Asp Lys Tyr Asp Leu Phe Val Gly Ser Gln Ala Thr Asp 
    290                 295                 300                 


Phe Gly Glu Ala Leu Val Arg His Asp Glu Phe 
305                 310                 315 


<210>  2020
<211>  323
<212>  PRT
<213>  Homo Sapiens

<400>  2020

Met Lys Glu Thr Asp Leu Ile Ile Met Asp Leu Arg Gln Phe Leu Met 
1               5                   10                  15      


Cys Leu Ser Leu Cys Thr Ala Phe Ala Leu Ser Lys Pro Thr Glu Lys 
            20                  25                  30          


Lys Asp Arg Val His His Glu Pro Gln Leu Ser Asp Lys Val His Asn 
        35                  40                  45              


Asp Ala Gln Ser Phe Asp Tyr Asp His Asp Ala Phe Leu Gly Ala Glu 
    50                  55                  60                  


Glu Ala Lys Thr Phe Asp Gln Leu Thr Pro Glu Glu Ser Lys Glu Arg 
65                  70                  75                  80  


Leu Gly Lys Ile Val Ser Lys Ile Asp Gly Asp Lys Asp Gly Phe Val 
                85                  90                  95      


Thr Val Asp Glu Leu Lys Asp Trp Ile Lys Phe Ala Gln Lys Arg Trp 
            100                 105                 110         


Ile Tyr Glu Asp Val Glu Arg Gln Trp Lys Gly His Asp Leu Asn Glu 
        115                 120                 125             


Asp Gly Leu Val Ser Trp Glu Glu Tyr Lys Asn Ala Thr Tyr Gly Tyr 
    130                 135                 140                 


Val Leu Asp Asp Pro Asp Pro Asp Asp Gly Phe Asn Tyr Lys Gln Met 
145                 150                 155                 160 


Met Val Arg Asp Glu Arg Arg Phe Lys Met Ala Asp Lys Asp Gly Asp 
                165                 170                 175     


Leu Ile Ala Thr Lys Glu Glu Phe Thr Ala Phe Leu His Pro Glu Glu 
            180                 185                 190         


Tyr Asp Tyr Met Lys Asp Ile Val Val Gln Glu Thr Met Glu Asp Ile 
        195                 200                 205             


Asp Lys Asn Ala Asp Gly Phe Ile Asp Leu Glu Glu Tyr Ile Gly Asp 
    210                 215                 220                 


Met Tyr Ser His Asp Gly Asn Thr Asp Glu Pro Glu Trp Val Lys Thr 
225                 230                 235                 240 


Glu Arg Glu Gln Phe Val Glu Phe Arg Asp Lys Asn Arg Asp Gly Lys 
                245                 250                 255     


Met Asp Lys Glu Glu Thr Lys Asp Trp Ile Leu Pro Ser Asp Tyr Asp 
            260                 265                 270         


His Ala Glu Ala Glu Ala Arg His Leu Val Tyr Glu Ser Asp Gln Asn 
        275                 280                 285             


Lys Asp Gly Lys Leu Thr Lys Glu Glu Ile Val Asp Lys Tyr Asp Leu 
    290                 295                 300                 


Phe Val Gly Ser Gln Ala Thr Asp Phe Gly Glu Ala Leu Val Arg His 
305                 310                 315                 320 


Asp Glu Phe 
            


<210>  2021
<211>  323
<212>  PRT
<213>  Homo Sapiens

<400>  2021

Met Lys Glu Thr Asp Leu Ile Ile Met Asp Leu Arg Gln Phe Leu Met 
1               5                   10                  15      


Cys Leu Ser Leu Cys Thr Ala Phe Ala Leu Ser Lys Pro Thr Glu Lys 
            20                  25                  30          


Lys Asp Arg Val His His Glu Pro Gln Leu Ser Asp Lys Val His Asn 
        35                  40                  45              


Asp Ala Gln Ser Phe Asp Tyr Asp His Asp Ala Phe Leu Gly Ala Glu 
    50                  55                  60                  


Glu Ala Lys Thr Phe Asp Gln Leu Thr Pro Glu Glu Ser Lys Glu Arg 
65                  70                  75                  80  


Leu Gly Met Ile Val Asp Lys Ile Asp Ala Asp Lys Asp Gly Phe Val 
                85                  90                  95      


Thr Glu Gly Glu Leu Lys Ser Trp Ile Lys His Ala Gln Lys Lys Tyr 
            100                 105                 110         


Ile Tyr Asp Asn Val Glu Asn Gln Trp Gln Glu Phe Asp Met Asn Gln 
        115                 120                 125             


Asp Gly Leu Ile Ser Trp Asp Glu Tyr Arg Asn Val Thr Tyr Gly Thr 
    130                 135                 140                 


Tyr Leu Asp Asp Pro Asp Pro Asp Asp Gly Phe Asn Tyr Lys Gln Met 
145                 150                 155                 160 


Met Val Arg Asp Glu Arg Arg Phe Lys Met Ala Asp Lys Asp Gly Asp 
                165                 170                 175     


Leu Ile Ala Thr Lys Glu Glu Phe Thr Ala Phe Leu His Pro Glu Glu 
            180                 185                 190         


Tyr Asp Tyr Met Lys Asp Ile Val Val Gln Glu Thr Met Glu Asp Ile 
        195                 200                 205             


Asp Lys Asn Ala Asp Gly Phe Ile Asp Leu Glu Glu Tyr Ile Gly Asp 
    210                 215                 220                 


Met Tyr Ser His Asp Gly Asn Thr Asp Glu Pro Glu Trp Val Lys Thr 
225                 230                 235                 240 


Glu Arg Glu Gln Phe Val Glu Phe Arg Asp Lys Asn Arg Asp Gly Lys 
                245                 250                 255     


Met Asp Lys Glu Glu Thr Lys Asp Trp Ile Leu Pro Ser Asp Tyr Asp 
            260                 265                 270         


His Ala Glu Ala Glu Ala Arg His Leu Val Tyr Glu Ser Asp Gln Asn 
        275                 280                 285             


Lys Asp Gly Lys Leu Thr Lys Glu Glu Ile Val Asp Lys Tyr Asp Leu 
    290                 295                 300                 


Phe Val Gly Ser Gln Ala Thr Asp Phe Gly Glu Ala Leu Val Arg His 
305                 310                 315                 320 


Asp Glu Phe 
            


<210>  2022
<211>  147
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2022

Xaa Ile Ala Thr Lys Glu Glu Phe Thr Ala Phe Leu His Pro Glu Glu 
1               5                   10                  15      


Tyr Asp Tyr Met Lys Asp Ile Val Val Gln Glu Thr Met Glu Asp Ile 
            20                  25                  30          


Asp Lys Asn Ala Asp Gly Phe Ile Asp Leu Glu Glu Tyr Ile Gly Asp 
        35                  40                  45              


Met Tyr Ser His Asp Gly Asn Thr Asp Glu Pro Glu Trp Val Lys Thr 
    50                  55                  60                  


Glu Arg Glu Gln Phe Val Glu Phe Arg Asp Lys Asn Arg Asp Gly Lys 
65                  70                  75                  80  


Met Asp Lys Glu Glu Thr Lys Asp Trp Ile Leu Pro Ser Asp Tyr Asp 
                85                  90                  95      


His Ala Glu Ala Glu Ala Arg His Leu Val Tyr Glu Ser Asp Gln Asn 
            100                 105                 110         


Lys Asp Gly Lys Leu Thr Lys Glu Glu Ile Val Asp Lys Tyr Asp Leu 
        115                 120                 125             


Phe Val Gly Ser Gln Ala Thr Asp Phe Gly Glu Ala Leu Val Arg His 
    130                 135                 140                 


Asp Glu Phe 
145         


<210>  2023
<211>  194
<212>  PRT
<213>  Homo Sapiens

<400>  2023

Ile Leu Leu Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg 
1               5                   10                  15      


Leu Tyr Gln Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu 
            20                  25                  30          


Trp Asp Thr Val Thr Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu 
        35                  40                  45              


Thr Ile Asn Pro Ala Lys Arg Ile Thr Ala Ser Glu Ala Leu Lys His 
    50                  55                  60                  


Pro Trp Ile Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln 
65                  70                  75                  80  


Glu Thr Val Asp Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys 
                85                  90                  95      


Gly Ala Ile Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Ala Lys 
            100                 105                 110         


Ser Leu Leu Lys Lys Pro Asp Gly Val Lys Ser Thr Glu Ser Ser Asn 
        115                 120                 125             


Thr Thr Ile Glu Asp Glu Asp Val Lys Ala Arg Lys Gln Glu Ile Ile 
    130                 135                 140                 


Lys Val Thr Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu 
145                 150                 155                 160 


Ala Tyr Thr Lys Ile Cys Asp Pro Gly Leu Thr Ala Phe Glu Pro Glu 
                165                 170                 175     


Ala Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe 
            180                 185                 190         


Glu Asn 
        


<210>  2024
<211>  512
<212>  PRT
<213>  Homo Sapiens

<400>  2024

Met Ala Ser Thr Thr Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Met 
            20                  25                  30          


Lys Ile Pro Thr Gly Gln Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His 
        115                 120                 125             


Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Ser Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Met Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
225                 230                 235                 240 


Val Thr Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu Thr Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Thr Ala Ser Glu Ala Leu Lys His Pro Trp Ile 
            260                 265                 270         


Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
        275                 280                 285             


Asp Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Ala Ala Lys Ser Leu 
305                 310                 315                 320 


Leu Lys Lys Pro Asp Gly Val Lys Ile Asn Asn Lys Ala Asn Val Val 
                325                 330                 335     


Thr Ser Pro Lys Glu Asn Ile Pro Thr Pro Ala Leu Glu Pro Gln Thr 
            340                 345                 350         


Thr Val Ile His Asn Pro Asp Gly Asn Lys Glu Ser Thr Glu Ser Ser 
        355                 360                 365             


Asn Thr Thr Ile Glu Asp Glu Asp Val Lys Ala Arg Lys Gln Glu Ile 
    370                 375                 380                 


Ile Lys Val Thr Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe 
385                 390                 395                 400 


Glu Ala Tyr Thr Lys Ile Cys Asp Pro Gly Leu Thr Ala Phe Glu Pro 
                405                 410                 415     


Glu Ala Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr 
            420                 425                 430         


Phe Glu Asn Ala Leu Ser Lys Ser Asn Lys Pro Ile His Thr Ile Ile 
        435                 440                 445             


Leu Asn Pro His Val His Leu Val Gly Asp Asp Ala Ala Cys Ile Ala 
    450                 455                 460                 


Tyr Ile Arg Leu Thr Gln Tyr Met Asp Gly Ser Gly Met Pro Lys Thr 
465                 470                 475                 480 


Met Gln Ser Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp 
                485                 490                 495     


Gln Asn Val His Phe His Arg Ser Gly Ser Pro Thr Val Pro Ile Lys 
            500                 505                 510         


<210>  2025
<211>  533
<212>  PRT
<213>  Homo Sapiens

<400>  2025

Met Ala Ser Thr Thr Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Met 
            20                  25                  30          


Lys Ile Pro Thr Gly Gln Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His 
        115                 120                 125             


Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Ser Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Met Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
225                 230                 235                 240 


Val Thr Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu Thr Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Thr Ala Ser Glu Ala Leu Lys His Pro Trp Ile 
            260                 265                 270         


Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
        275                 280                 285             


Asp Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Ala Ala Lys Ser Leu 
305                 310                 315                 320 


Leu Lys Lys Pro Asp Gly Val Lys Ile Asn Asn Lys Ala Asn Val Val 
                325                 330                 335     


Thr Ser Pro Lys Glu Asn Ile Pro Thr Pro Ala Leu Glu Pro Gln Thr 
            340                 345                 350         


Thr Val Ile His Asn Pro Asp Gly Asn Lys Glu Ser Thr Glu Ser Ser 
        355                 360                 365             


Asn Thr Thr Ile Glu Asp Glu Asp Val Lys Ala Arg Lys Gln Glu Ile 
    370                 375                 380                 


Ile Lys Val Thr Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe 
385                 390                 395                 400 


Glu Ala Tyr Thr Lys Ile Cys Asp Pro Gly Leu Thr Ala Phe Glu Pro 
                405                 410                 415     


Glu Ala Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr 
            420                 425                 430         


Phe Glu Asn Ala Leu Ser Lys Ser Asn Lys Pro Ile His Thr Ile Ile 
        435                 440                 445             


Leu Asn Pro His Val His Leu Val Gly Asp Asp Ala Ala Cys Ile Ala 
    450                 455                 460                 


Tyr Ile Arg Leu Thr Gln Tyr Met Asp Gly Ser Gly Met Pro Lys Thr 
465                 470                 475                 480 


Met Gln Ser Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp 
                485                 490                 495     


Gln Asn Val His Phe His Arg Ser Gly Ser Pro Thr Val Pro Ile Lys 
            500                 505                 510         


Pro Pro Cys Ile Pro Asn Gly Lys Glu Asn Phe Ser Gly Gly Thr Ser 
        515                 520                 525             


Leu Trp Gln Asn Ile 
    530             


<210>  2026
<211>  478
<212>  PRT
<213>  Homo Sapiens

<400>  2026

Met Ala Ser Thr Thr Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Met 
            20                  25                  30          


Lys Ile Pro Thr Gly Gln Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ser Val Asn His Cys His 
        115                 120                 125             


Leu Asn Gly Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Ser Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Met Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
225                 230                 235                 240 


Val Thr Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu Thr Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Thr Ala Ser Glu Ala Leu Lys His Pro Trp Ile 
            260                 265                 270         


Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
        275                 280                 285             


Asp Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Ala Ala Lys Ser Leu 
305                 310                 315                 320 


Leu Lys Lys Pro Asp Gly Val Lys Glu Ser Thr Glu Ser Ser Asn Thr 
                325                 330                 335     


Thr Ile Glu Asp Glu Asp Val Lys Ala Arg Lys Gln Glu Ile Ile Lys 
            340                 345                 350         


Val Thr Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu Ala 
        355                 360                 365             


Tyr Thr Lys Ile Cys Asp Pro Gly Leu Thr Ala Phe Glu Pro Glu Ala 
    370                 375                 380                 


Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe Glu 
385                 390                 395                 400 


Asn Ala Leu Ser Lys Ser Asn Lys Pro Ile His Thr Ile Ile Leu Asn 
                405                 410                 415     


Pro His Val His Leu Val Gly Asp Asp Ala Ala Cys Ile Ala Tyr Ile 
            420                 425                 430         


Arg Leu Thr Gln Tyr Met Asp Gly Ser Gly Met Pro Lys Thr Met Gln 
        435                 440                 445             


Ser Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn 
    450                 455                 460                 


Val His Phe His Arg Ser Gly Ser Pro Thr Val Pro Ile Lys 
465                 470                 475             


<210>  2027
<211>  499
<212>  PRT
<213>  Homo Sapiens

<400>  2027

Met Ala Ser Thr Thr Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Met 
            20                  25                  30          


Lys Ile Pro Thr Gly Gln Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ser Val Asn His Cys His 
        115                 120                 125             


Leu Asn Gly Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Ser Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Met Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
225                 230                 235                 240 


Val Thr Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu Thr Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Thr Ala Ser Glu Ala Leu Lys His Pro Trp Ile 
            260                 265                 270         


Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
        275                 280                 285             


Asp Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Ala Ala Lys Ser Leu 
305                 310                 315                 320 


Leu Lys Lys Pro Asp Gly Val Lys Glu Ser Thr Glu Ser Ser Asn Thr 
                325                 330                 335     


Thr Ile Glu Asp Glu Asp Val Lys Ala Arg Lys Gln Glu Ile Ile Lys 
            340                 345                 350         


Val Thr Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu Ala 
        355                 360                 365             


Tyr Thr Lys Ile Cys Asp Pro Gly Leu Thr Ala Phe Glu Pro Glu Ala 
    370                 375                 380                 


Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe Glu 
385                 390                 395                 400 


Asn Ala Leu Ser Lys Ser Asn Lys Pro Ile His Thr Ile Ile Leu Asn 
                405                 410                 415     


Pro His Val His Leu Val Gly Asp Asp Ala Ala Cys Ile Ala Tyr Ile 
            420                 425                 430         


Arg Leu Thr Gln Tyr Met Asp Gly Ser Gly Met Pro Lys Thr Met Gln 
        435                 440                 445             


Ser Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn 
    450                 455                 460                 


Val His Phe His Arg Ser Gly Ser Pro Thr Val Pro Ile Lys Pro Pro 
465                 470                 475                 480 


Cys Ile Pro Asn Gly Lys Glu Asn Phe Ser Gly Gly Thr Ser Leu Trp 
                485                 490                 495     


Gln Asn Ile 
            


<210>  2028
<211>  492
<212>  PRT
<213>  Homo Sapiens

<400>  2028

Met Ala Ser Thr Thr Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Met 
            20                  25                  30          


Lys Ile Pro Thr Gly Gln Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ser Val Asn His Cys His 
        115                 120                 125             


Leu Asn Gly Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Ser Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Met Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
225                 230                 235                 240 


Val Thr Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu Thr Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Thr Ala Ser Glu Ala Leu Lys His Pro Trp Ile 
            260                 265                 270         


Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
        275                 280                 285             


Asp Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Ala Ala Lys Ser Leu 
305                 310                 315                 320 


Leu Lys Lys Pro Asp Gly Val Lys Glu Pro Gln Thr Thr Val Ile His 
                325                 330                 335     


Asn Pro Asp Gly Asn Lys Glu Ser Thr Glu Ser Ser Asn Thr Thr Ile 
            340                 345                 350         


Glu Asp Glu Asp Val Lys Ala Arg Lys Gln Glu Ile Ile Lys Val Thr 
        355                 360                 365             


Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu Ala Tyr Thr 
    370                 375                 380                 


Lys Ile Cys Asp Pro Gly Leu Thr Ala Phe Glu Pro Glu Ala Leu Gly 
385                 390                 395                 400 


Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe Glu Asn Ala 
                405                 410                 415     


Leu Ser Lys Ser Asn Lys Pro Ile His Thr Ile Ile Leu Asn Pro His 
            420                 425                 430         


Val His Leu Val Gly Asp Asp Ala Ala Cys Ile Ala Tyr Ile Arg Leu 
        435                 440                 445             


Thr Gln Tyr Met Asp Gly Ser Gly Met Pro Lys Thr Met Gln Ser Glu 
    450                 455                 460                 


Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn Val His 
465                 470                 475                 480 


Phe His Arg Ser Gly Ser Pro Thr Val Pro Ile Lys 
                485                 490         


<210>  2029
<211>  478
<212>  PRT
<213>  Homo Sapiens

<400>  2029

Met Ala Ser Thr Thr Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Met 
            20                  25                  30          


Lys Ile Pro Thr Gly Gln Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ser Val Asn His Cys His 
        115                 120                 125             


Leu Asn Gly Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Ser Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Met Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
225                 230                 235                 240 


Val Thr Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu Thr Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Thr Ala Ser Glu Ala Leu Lys His Pro Trp Ile 
            260                 265                 270         


Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
        275                 280                 285             


Asp Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Ala Ala Lys Ser Leu 
305                 310                 315                 320 


Leu Lys Lys Pro Asp Gly Val Lys Glu Ser Thr Glu Ser Ser Asn Thr 
                325                 330                 335     


Thr Ile Glu Asp Glu Asp Val Lys Ala Arg Lys Gln Glu Ile Ile Lys 
            340                 345                 350         


Val Thr Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu Ala 
        355                 360                 365             


Tyr Thr Lys Ile Cys Asp Pro Gly Leu Thr Ala Phe Glu Pro Glu Ala 
    370                 375                 380                 


Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe Glu 
385                 390                 395                 400 


Asn Ala Leu Ser Lys Ser Asn Lys Pro Ile His Thr Ile Ile Leu Asn 
                405                 410                 415     


Pro His Val His Leu Val Gly Asp Asp Ala Ala Cys Ile Ala Tyr Ile 
            420                 425                 430         


Arg Leu Thr Gln Tyr Met Asp Gly Ser Gly Met Pro Lys Thr Met Gln 
        435                 440                 445             


Ser Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn 
    450                 455                 460                 


Val His Phe His Arg Ser Gly Ser Pro Thr Val Pro Ile Asn 
465                 470                 475             


<210>  2030
<211>  478
<212>  PRT
<213>  Homo Sapiens

<400>  2030

Met Ala Ser Thr Thr Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Met 
            20                  25                  30          


Lys Ile Pro Thr Gly Gln Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ser Val Asn His Cys His 
        115                 120                 125             


Leu Asn Gly Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Ser Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Met Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
225                 230                 235                 240 


Val Thr Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu Thr Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Thr Ala Ser Glu Ala Leu Lys His Pro Trp Ile 
            260                 265                 270         


Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
        275                 280                 285             


Asp Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Ala Ala Lys Ser Leu 
305                 310                 315                 320 


Leu Lys Lys Pro Asp Gly Val Lys Glu Ser Thr Glu Ser Ser Asn Thr 
                325                 330                 335     


Thr Ile Glu Asp Glu Asp Val Lys Ala Arg Lys Gln Glu Ile Ile Lys 
            340                 345                 350         


Val Thr Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu Ala 
        355                 360                 365             


Tyr Thr Lys Ile Cys Asp Pro Gly Leu Thr Ala Phe Glu Pro Glu Ala 
    370                 375                 380                 


Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe Glu 
385                 390                 395                 400 


Asn Ala Leu Ser Lys Ser Asn Lys Pro Ile His Thr Ile Ile Leu Asn 
                405                 410                 415     


Pro His Val His Leu Val Gly Asp Asp Ala Ala Cys Ile Ala Tyr Ile 
            420                 425                 430         


Arg Leu Thr Gln Tyr Met Asp Gly Ser Gly Met Pro Lys Thr Met Gln 
        435                 440                 445             


Ser Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn 
    450                 455                 460                 


Val His Phe His Arg Ser Gly Ser Pro Thr Val Pro Ile Lys 
465                 470                 475             


<210>  2031
<211>  510
<212>  PRT
<213>  Homo Sapiens

<400>  2031

Met Ala Ser Thr Thr Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Met 
            20                  25                  30          


Lys Ile Pro Thr Gly Gln Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ser Val Asn His Cys His 
        115                 120                 125             


Leu Asn Gly Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Ser Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Met Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
225                 230                 235                 240 


Val Thr Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu Thr Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Thr Ala Ser Glu Ala Leu Lys His Pro Trp Ile 
            260                 265                 270         


Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
        275                 280                 285             


Asp Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Ala Ala Lys Ser Leu 
305                 310                 315                 320 


Leu Lys Lys Pro Asp Gly Val Lys Lys Arg Lys Ser Ser Ser Ser Val 
                325                 330                 335     


Gln Met Met Glu Ser Thr Glu Ser Ser Asn Thr Thr Ile Glu Asp Glu 
            340                 345                 350         


Asp Val Lys Ala Arg Lys Gln Glu Ile Ile Lys Val Thr Glu Gln Leu 
        355                 360                 365             


Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu Ala Tyr Thr Lys Ile Cys 
    370                 375                 380                 


Asp Pro Gly Leu Thr Ala Phe Glu Pro Glu Ala Leu Gly Asn Leu Val 
385                 390                 395                 400 


Glu Gly Met Asp Phe His Arg Phe Tyr Phe Glu Asn Ala Leu Ser Lys 
                405                 410                 415     


Ser Asn Lys Pro Ile His Thr Ile Ile Leu Asn Pro His Val His Leu 
            420                 425                 430         


Val Gly Asp Asp Ala Ala Cys Ile Ala Tyr Ile Arg Leu Thr Gln Tyr 
        435                 440                 445             


Met Asp Gly Ser Gly Met Pro Lys Thr Met Gln Ser Glu Glu Thr Arg 
    450                 455                 460                 


Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn Val His Phe His Arg 
465                 470                 475                 480 


Ser Gly Ser Pro Thr Val Pro Ile Lys Pro Pro Cys Ile Pro Asn Gly 
                485                 490                 495     


Lys Glu Asn Phe Ser Gly Gly Thr Ser Leu Trp Gln Asn Ile 
            500                 505                 510 


<210>  2032
<211>  489
<212>  PRT
<213>  Homo Sapiens

<400>  2032

Met Ala Ser Thr Thr Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Met 
            20                  25                  30          


Lys Ile Pro Thr Gly Gln Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ser Val Asn His Cys His 
        115                 120                 125             


Leu Asn Gly Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Ser Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Met Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
225                 230                 235                 240 


Val Thr Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu Thr Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Thr Ala Ser Glu Ala Leu Lys His Pro Trp Ile 
            260                 265                 270         


Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
        275                 280                 285             


Asp Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Ala Ala Lys Ser Leu 
305                 310                 315                 320 


Leu Lys Lys Pro Asp Gly Val Lys Lys Arg Lys Ser Ser Ser Ser Val 
                325                 330                 335     


Gln Met Met Glu Ser Thr Glu Ser Ser Asn Thr Thr Ile Glu Asp Glu 
            340                 345                 350         


Asp Val Lys Ala Arg Lys Gln Glu Ile Ile Lys Val Thr Glu Gln Leu 
        355                 360                 365             


Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu Ala Tyr Thr Lys Ile Cys 
    370                 375                 380                 


Asp Pro Gly Leu Thr Ala Phe Glu Pro Glu Ala Leu Gly Asn Leu Val 
385                 390                 395                 400 


Glu Gly Met Asp Phe His Arg Phe Tyr Phe Glu Asn Ala Leu Ser Lys 
                405                 410                 415     


Ser Asn Lys Pro Ile His Thr Ile Ile Leu Asn Pro His Val His Leu 
            420                 425                 430         


Val Gly Asp Asp Ala Ala Cys Ile Ala Tyr Ile Arg Leu Thr Gln Tyr 
        435                 440                 445             


Met Asp Gly Ser Gly Met Pro Lys Thr Met Gln Ser Glu Glu Thr Arg 
    450                 455                 460                 


Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn Val His Phe His Arg 
465                 470                 475                 480 


Ser Gly Ser Pro Thr Val Pro Ile Lys 
                485                 


<210>  2033
<211>  498
<212>  PRT
<213>  Homo Sapiens

<400>  2033

Met Ala Ser Thr Thr Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Met 
            20                  25                  30          


Lys Ile Pro Thr Gly Gln Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ser Val Asn His Cys His 
        115                 120                 125             


Leu Asn Gly Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Ser Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Met Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
225                 230                 235                 240 


Val Thr Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu Thr Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Thr Ala Ser Glu Ala Leu Lys His Pro Trp Ile 
            260                 265                 270         


Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
        275                 280                 285             


Asp Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Ala Lys Ser Leu Leu 
305                 310                 315                 320 


Lys Lys Pro Asp Gly Val Lys Glu Ser Thr Glu Ser Ser Asn Thr Thr 
                325                 330                 335     


Ile Glu Asp Glu Asp Val Lys Ala Arg Lys Gln Glu Ile Ile Lys Val 
            340                 345                 350         


Thr Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu Ala Tyr 
        355                 360                 365             


Thr Lys Ile Cys Asp Pro Gly Leu Thr Ala Phe Glu Pro Glu Ala Leu 
    370                 375                 380                 


Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe Glu Asn 
385                 390                 395                 400 


Ala Leu Ser Lys Ser Asn Lys Pro Ile His Thr Ile Ile Leu Asn Pro 
                405                 410                 415     


His Val His Leu Val Gly Asp Asp Ala Ala Cys Ile Ala Tyr Ile Arg 
            420                 425                 430         


Leu Thr Gln Tyr Met Asp Gly Ser Gly Met Pro Lys Thr Met Gln Ser 
        435                 440                 445             


Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn Val 
    450                 455                 460                 


His Phe His Arg Ser Gly Ser Pro Thr Val Pro Ile Lys Pro Pro Cys 
465                 470                 475                 480 


Ile Pro Asn Gly Lys Glu Asn Phe Ser Gly Gly Thr Ser Leu Trp Gln 
                485                 490                 495     


Asn Ile 
        


<210>  2034
<211>  182
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2034

Xaa Arg Lys Leu Lys Gly Ala Ile Leu Thr Thr Met Leu Ala Thr Arg 
1               5                   10                  15      


Asn Phe Ser Ala Ala Lys Ser Leu Leu Lys Lys Pro Asp Gly Val Lys 
            20                  25                  30          


Glu Ser Thr Glu Ser Ser Asn Thr Thr Ile Glu Asp Glu Asp Val Lys 
        35                  40                  45              


Ala Arg Lys Gln Glu Ile Ile Lys Val Thr Glu Gln Leu Ile Glu Ala 
    50                  55                  60                  


Ile Asn Asn Gly Asp Phe Glu Ala Tyr Thr Lys Ile Cys Asp Pro Gly 
65                  70                  75                  80  


Leu Thr Ala Phe Glu Pro Glu Ala Leu Gly Asn Leu Val Glu Gly Met 
                85                  90                  95      


Asp Phe His Arg Phe Tyr Phe Glu Asn Ala Leu Ser Lys Ser Asn Lys 
            100                 105                 110         


Pro Ile His Thr Ile Ile Leu Asn Pro His Val His Leu Val Gly Asp 
        115                 120                 125             


Asp Ala Ala Cys Ile Ala Tyr Ile Arg Leu Thr Gln Tyr Met Asp Gly 
    130                 135                 140                 


Ser Gly Met Pro Lys Thr Met Gln Ser Glu Glu Thr Arg Val Trp His 
145                 150                 155                 160 


Arg Arg Asp Gly Lys Trp Gln Asn Val His Phe His Arg Ser Gly Ser 
                165                 170                 175     


Pro Thr Val Pro Ile Lys 
            180         


<210>  2035
<211>  173
<212>  PRT
<213>  Homo Sapiens

<400>  2035

Met Gly Thr Met Lys Thr Gln Arg Asp Gly His Ser Leu Gly Arg Trp 
1               5                   10                  15      


Ser Leu Val Leu Leu Leu Leu Gly Leu Val Met Pro Leu Ala Ile Ile 
            20                  25                  30          


Ala Gln Val Leu Ser Tyr Lys Glu Ala Val Leu Arg Ala Ile Asp Gly 
        35                  40                  45              


Ile Asn Gln Arg Ser Ser Asp Ala Asn Leu Tyr Arg Leu Leu Asp Leu 
    50                  55                  60                  


Asp Pro Arg Pro Thr Met Asp Gly Asp Pro Asp Thr Pro Lys Pro Val 
65                  70                  75                  80  


Ser Phe Thr Val Lys Glu Thr Val Cys Pro Arg Thr Thr Gln Gln Ser 
                85                  90                  95      


Pro Glu Asp Cys Asp Phe Lys Lys Asp Gly Leu Val Lys Arg Cys Met 
            100                 105                 110         


Gly Thr Val Thr Leu Asn Gln Ala Arg Gly Ser Phe Asp Ile Ser Cys 
        115                 120                 125             


Asp Lys Asp Asn Lys Arg Phe Ala Leu Leu Gly Asp Phe Phe Arg Lys 
    130                 135                 140                 


Ser Lys Glu Lys Ile Gly Lys Glu Phe Lys Arg Ile Val Gln Arg Ile 
145                 150                 155                 160 


Lys Asp Phe Leu Arg Asn Leu Val Pro Arg Thr Glu Ser 
                165                 170             


<210>  2036
<211>  32
<212>  PRT
<213>  Homo Sapiens

<400>  2036

Met Glu Gly Lys Trp Leu Leu Cys Met Leu Leu Val Leu Gly Thr Ala 
1               5                   10                  15      


Ile Val Glu Ala His Asp Gly His Asp Asp Asp Val Ile Asp Ile Glu 
            20                  25                  30          


<210>  2037
<211>  61
<212>  PRT
<213>  Homo Sapiens

<400>  2037

Met Glu Gly Lys Trp Leu Leu Cys Met Leu Leu Val Leu Gly Thr Ala 
1               5                   10                  15      


Ile Val Glu Ala His Asp Gly His Asp Asp Asp Val Ile Asp Ile Glu 
            20                  25                  30          


Asp Asp Leu Asp Asp Val Ile Glu Glu Val Glu Asp Ser Lys Pro Asp 
        35                  40                  45              


Thr Thr Ala Pro Pro Ser Ser Pro Lys Glu Ser Gly Arg 
    50                  55                  60      


<210>  2038
<211>  79
<212>  PRT
<213>  Homo Sapiens

<400>  2038

Met Glu Gly Lys Trp Leu Leu Cys Met Leu Leu Val Leu Gly Thr Ala 
1               5                   10                  15      


Ile Val Glu Ala His Asp Gly His Asp Asp Asp Val Ile Asp Ile Glu 
            20                  25                  30          


Asp Asp Leu Asp Asp Val Ile Glu Glu Val Glu Asp Ser Lys Pro Asp 
        35                  40                  45              


Thr Thr Ala Pro Pro Ser Ser Pro Lys Val Thr Tyr Lys Ala Pro Val 
    50                  55                  60                  


Pro Thr Gly Glu Val Tyr Phe Ala Asp Ser Phe Asp Arg Gly Thr 
65                  70                  75                  


<210>  2039
<211>  96
<212>  PRT
<213>  Homo Sapiens

<400>  2039

Met Glu Gly Lys Trp Leu Leu Cys Met Leu Leu Val Leu Gly Thr Ala 
1               5                   10                  15      


Ile Val Glu Ala His Asp Gly His Asp Asp Asp Val Ile Asp Ile Glu 
            20                  25                  30          


Asp Asp Leu Asp Asp Val Ile Glu Glu Val Glu Asp Ser Lys Pro Asp 
        35                  40                  45              


Thr Thr Ala Pro Pro Ser Ser Pro Lys Val Thr Tyr Lys Ala Pro Val 
    50                  55                  60                  


Pro Thr Gly Glu Val Tyr Phe Ala Asp Ser Phe Asp Arg Gly Thr Leu 
65                  70                  75                  80  


Ser Gly Lys Val Gly Gly Arg Gly Asn Glu Gly Val Lys Ala Ser Arg 
                85                  90                  95      


<210>  2040
<211>  107
<212>  PRT
<213>  Homo Sapiens

<400>  2040

Met Glu Gly Lys Trp Leu Leu Cys Met Leu Leu Val Leu Gly Thr Ala 
1               5                   10                  15      


Ile Val Glu Ala His Asp Gly His Asp Asp Asp Val Ile Asp Ile Glu 
            20                  25                  30          


Asp Asp Leu Asp Asp Val Ile Glu Glu Val Glu Asp Ser Lys Pro Asp 
        35                  40                  45              


Thr Thr Ala Pro Pro Ser Ser Pro Lys Val Thr Tyr Lys Ala Pro Val 
    50                  55                  60                  


Pro Thr Gly Glu Val Tyr Phe Ala Asp Ser Phe Asp Arg Gly Thr Leu 
65                  70                  75                  80  


Ser Gly Trp Ile Leu Ser Lys Ala Lys Lys Asp Asp Thr Asp Asp Glu 
                85                  90                  95      


Ile Ala Lys Tyr Asp Gly Lys Trp Glu Val Glu 
            100                 105         


<210>  2041
<211>  134
<212>  PRT
<213>  Homo Sapiens

<400>  2041

Met Glu Gly Lys Trp Leu Leu Cys Met Leu Leu Val Leu Gly Thr Ala 
1               5                   10                  15      


Ile Val Glu Ala His Asp Gly His Asp Asp Asp Val Ile Asp Ile Glu 
            20                  25                  30          


Asp Asp Leu Asp Asp Val Ile Glu Glu Val Glu Asp Ser Lys Pro Asp 
        35                  40                  45              


Thr Thr Ala Pro Pro Ser Ser Pro Lys Val Thr Tyr Lys Ala Pro Val 
    50                  55                  60                  


Pro Thr Gly Glu Val Tyr Phe Ala Asp Ser Phe Asp Arg Gly Thr Leu 
65                  70                  75                  80  


Ser Gly Trp Ile Leu Ser Lys Ala Lys Lys Asp Asp Thr Asp Asp Glu 
                85                  90                  95      


Ile Ala Lys Tyr Asp Gly Lys Trp Glu Val Glu Glu Met Lys Glu Ser 
            100                 105                 110         


Lys Leu Pro Gly Asp Lys Gly Leu Val Leu Met Ser Arg Ala Lys His 
        115                 120                 125             


His Ala Ile Ser Ala Lys 
    130                 


<210>  2042
<211>  144
<212>  PRT
<213>  Homo Sapiens

<400>  2042

Met Glu Gly Lys Trp Leu Leu Cys Met Leu Leu Val Leu Gly Thr Ala 
1               5                   10                  15      


Ile Val Glu Ala His Asp Gly His Asp Asp Asp Val Ile Asp Ile Glu 
            20                  25                  30          


Asp Asp Leu Asp Asp Val Ile Glu Glu Val Glu Asp Ser Lys Pro Asp 
        35                  40                  45              


Thr Thr Ala Pro Pro Ser Ser Pro Lys Val Thr Tyr Lys Ala Pro Val 
    50                  55                  60                  


Pro Thr Gly Glu Val Tyr Phe Ala Asp Ser Phe Asp Arg Gly Thr Leu 
65                  70                  75                  80  


Ser Gly Trp Ile Leu Ser Lys Ala Lys Lys Asp Asp Thr Asp Asp Glu 
                85                  90                  95      


Ile Ala Lys Tyr Asp Gly Lys Trp Glu Val Glu Glu Met Lys Glu Ser 
            100                 105                 110         


Lys Leu Pro Gly Asp Lys Gly Leu Val Leu Met Ser Arg Ala Lys His 
        115                 120                 125             


His Ala Ile Ser Ala Lys Leu Asn Lys Pro Phe Leu Phe Asp Thr Lys 
    130                 135                 140                 


<210>  2043
<211>  168
<212>  PRT
<213>  Homo Sapiens

<400>  2043

Met Glu Gly Lys Trp Leu Leu Cys Met Leu Leu Val Leu Gly Thr Ala 
1               5                   10                  15      


Ile Val Glu Ala His Asp Gly His Asp Asp Asp Val Ile Asp Ile Glu 
            20                  25                  30          


Asp Asp Leu Asp Asp Val Ile Glu Glu Val Glu Asp Ser Lys Pro Asp 
        35                  40                  45              


Thr Thr Ala Pro Pro Ser Ser Pro Lys Val Thr Tyr Lys Ala Pro Val 
    50                  55                  60                  


Pro Thr Gly Glu Val Tyr Phe Ala Asp Ser Phe Asp Arg Gly Thr Leu 
65                  70                  75                  80  


Ser Gly Trp Ile Leu Ser Lys Ala Lys Lys Asp Asp Thr Asp Asp Glu 
                85                  90                  95      


Ile Ala Lys Tyr Asp Gly Lys Trp Glu Val Glu Glu Met Lys Glu Ser 
            100                 105                 110         


Lys Leu Pro Gly Asp Lys Gly Leu Val Leu Met Ser Arg Ala Lys His 
        115                 120                 125             


His Ala Ile Ser Ala Lys Leu Asn Lys Pro Phe Leu Phe Asp Thr Lys 
    130                 135                 140                 


Pro Leu Ile Val Gln Tyr Glu Val Asn Phe Gln Asn Gly Ile Glu Cys 
145                 150                 155                 160 


Gly Gly Ala Tyr Val Lys Leu Leu 
                165             


<210>  2044
<211>  592
<212>  PRT
<213>  Homo Sapiens

<400>  2044

Met Glu Gly Lys Trp Leu Leu Cys Met Leu Leu Val Leu Gly Thr Ala 
1               5                   10                  15      


Ile Val Glu Ala His Asp Gly His Asp Asp Asp Val Ile Asp Ile Glu 
            20                  25                  30          


Asp Asp Leu Asp Asp Val Ile Glu Glu Val Glu Asp Ser Lys Pro Asp 
        35                  40                  45              


Thr Thr Ala Pro Pro Ser Ser Pro Lys Val Thr Tyr Lys Ala Pro Val 
    50                  55                  60                  


Pro Thr Gly Glu Val Tyr Phe Ala Asp Ser Phe Asp Arg Gly Thr Leu 
65                  70                  75                  80  


Ser Gly Trp Ile Leu Ser Lys Ala Lys Lys Asp Asp Thr Asp Asp Glu 
                85                  90                  95      


Ile Ala Lys Tyr Asp Gly Lys Trp Glu Val Glu Glu Met Lys Glu Ser 
            100                 105                 110         


Lys Leu Pro Gly Asp Lys Gly Leu Val Leu Met Ser Arg Ala Lys His 
        115                 120                 125             


His Ala Ile Ser Ala Lys Leu Asn Lys Pro Phe Leu Phe Asp Thr Lys 
    130                 135                 140                 


Pro Leu Ile Val Gln Tyr Glu Val Asn Phe Gln Asn Gly Ile Glu Cys 
145                 150                 155                 160 


Gly Gly Ala Tyr Val Lys Leu Leu Ser Lys Thr Pro Glu Leu Asn Leu 
                165                 170                 175     


Asp Gln Phe His Asp Lys Thr Pro Tyr Thr Ile Met Phe Gly Pro Asp 
            180                 185                 190         


Lys Cys Gly Glu Asp Tyr Lys Leu His Phe Ile Phe Arg His Lys Asn 
        195                 200                 205             


Pro Lys Thr Gly Ile Tyr Glu Glu Lys His Ala Lys Arg Pro Asp Ala 
    210                 215                 220                 


Asp Leu Lys Thr Tyr Phe Thr Asp Lys Lys Thr His Leu Tyr Thr Leu 
225                 230                 235                 240 


Ile Leu Asn Pro Asp Asn Ser Phe Glu Ile Leu Val Asp Gln Ser Val 
                245                 250                 255     


Val Asn Ser Gly Asn Leu Leu Asn Asp Met Thr Pro Pro Val Asn Pro 
            260                 265                 270         


Ser Arg Glu Ile Glu Asp Pro Glu Asp Arg Lys Pro Glu Asp Trp Asp 
        275                 280                 285             


Glu Arg Pro Lys Ile Pro Asp Pro Glu Ala Val Lys Pro Asp Asp Trp 
    290                 295                 300                 


Asp Glu Asp Ala Pro Ala Lys Ile Pro Asp Glu Glu Ala Thr Lys Pro 
305                 310                 315                 320 


Glu Gly Trp Leu Asp Asp Glu Pro Glu Tyr Val Pro Asp Pro Asp Ala 
                325                 330                 335     


Glu Lys Pro Glu Asp Trp Asp Glu Asp Met Asp Gly Glu Trp Glu Ala 
            340                 345                 350         


Pro Gln Ile Ala Asn Pro Arg Cys Glu Ser Ala Pro Gly Cys Gly Val 
        355                 360                 365             


Trp Gln Arg Pro Val Ile Asp Asn Pro Asn Tyr Lys Gly Lys Trp Lys 
    370                 375                 380                 


Pro Pro Met Ile Asp Asn Pro Ser Tyr Gln Gly Ile Trp Lys Pro Arg 
385                 390                 395                 400 


Lys Ile Pro Asn Pro Asp Phe Phe Glu Asp Leu Glu Pro Phe Arg Met 
                405                 410                 415     


Thr Pro Phe Ser Ala Ile Gly Leu Glu Leu Trp Ser Met Thr Ser Asp 
            420                 425                 430         


Ile Phe Phe Asp Asn Phe Ile Ile Cys Ala Asp Arg Arg Ile Val Asp 
        435                 440                 445             


Asp Trp Ala Asn Asp Gly Trp Gly Leu Lys Lys Ala Ala Asp Gly Ala 
    450                 455                 460                 


Ala Glu Pro Gly Val Val Gly Gln Met Ile Glu Ala Ala Glu Glu Arg 
465                 470                 475                 480 


Pro Trp Leu Trp Val Val Tyr Ile Leu Thr Val Ala Leu Pro Val Phe 
                485                 490                 495     


Leu Val Ile Leu Phe Cys Cys Ser Gly Lys Lys Gln Thr Ser Gly Met 
            500                 505                 510         


Glu Tyr Lys Lys Thr Asp Ala Pro Gln Pro Asp Val Lys Glu Glu Glu 
        515                 520                 525             


Glu Glu Lys Glu Glu Glu Lys Asp Lys Gly Asp Glu Glu Glu Glu Gly 
    530                 535                 540                 


Glu Glu Lys Leu Glu Glu Lys Gln Lys Ser Asp Ala Glu Glu Asp Gly 
545                 550                 555                 560 


Gly Thr Val Ser Gln Glu Glu Glu Asp Arg Lys Pro Lys Ala Glu Glu 
                565                 570                 575     


Asp Glu Ile Leu Asn Arg Ser Pro Arg Asn Arg Lys Pro Arg Arg Glu 
            580                 585                 590         


<210>  2045
<211>  592
<212>  PRT
<213>  Homo Sapiens

<400>  2045

Met Glu Gly Lys Trp Leu Leu Cys Met Leu Leu Val Leu Gly Thr Ala 
1               5                   10                  15      


Ile Val Glu Ala His Asp Gly His Asp Asp Asp Val Ile Asp Ile Glu 
            20                  25                  30          


Asp Asp Leu Asp Asp Val Ile Glu Glu Val Glu Asp Ser Lys Pro Asp 
        35                  40                  45              


Thr Thr Ala Pro Pro Ser Ser Pro Lys Val Thr Tyr Lys Ala Pro Val 
    50                  55                  60                  


Pro Thr Gly Glu Val Tyr Phe Ala Asp Ser Phe Asp Arg Gly Thr Leu 
65                  70                  75                  80  


Ser Gly Trp Ile Leu Ser Lys Ala Lys Lys Asp Asp Thr Asp Asp Glu 
                85                  90                  95      


Ile Ala Lys Tyr Asp Gly Lys Trp Glu Val Glu Glu Met Lys Glu Ser 
            100                 105                 110         


Lys Leu Pro Gly Asp Lys Gly Leu Val Leu Met Ser Arg Ala Lys His 
        115                 120                 125             


His Ala Ile Ser Ala Lys Leu Asn Lys Pro Phe Leu Phe Asp Thr Lys 
    130                 135                 140                 


Pro Leu Ile Val Gln Tyr Glu Val Asn Phe Gln Asn Gly Ile Glu Cys 
145                 150                 155                 160 


Gly Gly Ala Tyr Val Lys Leu Leu Ser Lys Thr Pro Glu Leu Asn Leu 
                165                 170                 175     


Asp Gln Phe His Asp Lys Thr Pro Tyr Thr Ile Met Phe Gly Pro Asp 
            180                 185                 190         


Lys Cys Gly Glu Asp Tyr Lys Leu His Phe Ile Phe Arg His Lys Asn 
        195                 200                 205             


Pro Lys Thr Gly Ile Tyr Glu Glu Lys His Ala Lys Arg Pro Asp Ala 
    210                 215                 220                 


Asp Leu Lys Thr Tyr Phe Thr Asp Lys Lys Thr His Leu Tyr Thr Leu 
225                 230                 235                 240 


Ile Leu Asn Pro Asp Asn Ser Phe Glu Ile Leu Val Asp Gln Ser Val 
                245                 250                 255     


Val Asn Ser Gly Asn Leu Leu Asn Asp Met Thr Pro Pro Val Asn Pro 
            260                 265                 270         


Ser Arg Glu Ile Glu Asp Pro Glu Asp Arg Lys Pro Glu Asp Trp Asp 
        275                 280                 285             


Glu Arg Pro Lys Ile Pro Asp Pro Glu Ala Val Lys Pro Asp Asp Trp 
    290                 295                 300                 


Asp Glu Asp Ala Pro Ala Lys Ile Pro Asp Glu Glu Ala Thr Lys Pro 
305                 310                 315                 320 


Glu Gly Trp Leu Asp Asp Glu Pro Glu Tyr Val Pro Asp Pro Asp Ala 
                325                 330                 335     


Glu Lys Pro Glu Asp Trp Asp Glu Asp Met Asp Gly Glu Trp Glu Ala 
            340                 345                 350         


Pro Gln Ile Ala Asn Pro Arg Cys Glu Ser Ala Pro Gly Cys Gly Val 
        355                 360                 365             


Trp Gln Arg Pro Val Ile Asp Asn Pro Asn Tyr Lys Gly Lys Trp Lys 
    370                 375                 380                 


Pro Pro Met Ile Asp Asn Pro Ser Tyr Gln Gly Ile Trp Lys Pro Arg 
385                 390                 395                 400 


Lys Ile Pro Asn Pro Asp Phe Phe Glu Asp Leu Glu Pro Phe Arg Met 
                405                 410                 415     


Thr Pro Phe Ser Ala Ile Gly Leu Glu Leu Trp Ser Met Thr Ser Asp 
            420                 425                 430         


Ile Phe Phe Asp Asn Phe Ile Ile Cys Ala Asp Arg Arg Ile Val Asp 
        435                 440                 445             


Asp Trp Ala Asn Asp Gly Trp Gly Leu Lys Lys Ala Ala Asp Gly Ala 
    450                 455                 460                 


Ala Glu Pro Gly Val Val Gly Gln Met Ile Glu Ala Ala Glu Glu Arg 
465                 470                 475                 480 


Pro Trp Leu Trp Val Val Tyr Ile Leu Thr Val Ala Leu Pro Val Phe 
                485                 490                 495     


Leu Val Ile Leu Phe Cys Cys Ser Gly Lys Lys Gln Thr Ser Gly Met 
            500                 505                 510         


Glu Tyr Lys Lys Thr Asp Ala Pro Gln Pro Asp Val Lys Glu Glu Glu 
        515                 520                 525             


Glu Glu Lys Glu Glu Glu Lys Asp Lys Gly Asp Glu Glu Glu Glu Gly 
    530                 535                 540                 


Glu Glu Lys Leu Glu Glu Lys Gln Lys Ser Asp Ala Glu Glu Asp Gly 
545                 550                 555                 560 


Gly Thr Val Ser Gln Glu Glu Glu Asp Arg Lys Pro Lys Ala Glu Glu 
                565                 570                 575     


Asp Glu Ile Leu Asn Arg Ser Pro Arg Asn Arg Lys Pro Arg Arg Glu 
            580                 585                 590         


<210>  2046
<211>  592
<212>  PRT
<213>  Homo Sapiens

<400>  2046

Met Glu Gly Lys Trp Leu Leu Cys Met Leu Leu Val Leu Gly Thr Ala 
1               5                   10                  15      


Ile Val Glu Ala His Asp Gly His Asp Asp Asp Val Ile Asp Ile Glu 
            20                  25                  30          


Asp Asp Leu Asp Asp Val Ile Glu Glu Val Glu Asp Ser Lys Pro Asp 
        35                  40                  45              


Thr Thr Ala Pro Pro Ser Ser Pro Lys Val Thr Tyr Lys Ala Pro Val 
    50                  55                  60                  


Pro Thr Gly Glu Val Tyr Phe Ala Asp Ser Phe Asp Arg Gly Thr Leu 
65                  70                  75                  80  


Ser Gly Trp Ile Leu Ser Lys Ala Lys Lys Asp Asp Thr Asp Asp Glu 
                85                  90                  95      


Ile Ala Lys Tyr Asp Gly Lys Trp Glu Val Glu Glu Met Lys Glu Ser 
            100                 105                 110         


Lys Leu Pro Gly Asp Lys Gly Leu Val Leu Met Ser Arg Ala Lys His 
        115                 120                 125             


His Ala Ile Ser Ala Lys Leu Asn Lys Pro Phe Leu Phe Asp Thr Lys 
    130                 135                 140                 


Pro Leu Ile Val Gln Tyr Glu Val Asn Phe Gln Asn Gly Ile Glu Cys 
145                 150                 155                 160 


Gly Gly Ala Tyr Val Lys Leu Leu Ser Lys Thr Pro Glu Leu Asn Leu 
                165                 170                 175     


Asp Gln Phe His Asp Lys Thr Pro Tyr Thr Ile Met Phe Gly Pro Asp 
            180                 185                 190         


Lys Cys Gly Glu Asp Tyr Lys Leu His Phe Ile Phe Arg His Lys Asn 
        195                 200                 205             


Pro Lys Thr Gly Ile Tyr Glu Glu Lys His Ala Lys Arg Pro Asp Ala 
    210                 215                 220                 


Asp Leu Lys Thr Tyr Phe Thr Asp Lys Lys Thr His Leu Tyr Thr Leu 
225                 230                 235                 240 


Ile Leu Asn Pro Asp Asn Ser Phe Glu Ile Leu Val Asp Gln Ser Val 
                245                 250                 255     


Val Asn Ser Gly Asn Leu Leu Asn Asp Met Thr Pro Pro Val Asn Pro 
            260                 265                 270         


Ser Arg Glu Ile Glu Asp Pro Glu Asp Arg Lys Pro Glu Asp Trp Asp 
        275                 280                 285             


Glu Arg Pro Lys Ile Pro Asp Pro Glu Ala Val Lys Pro Asp Asp Trp 
    290                 295                 300                 


Asp Glu Asp Ala Pro Ala Lys Ile Pro Asp Glu Glu Ala Thr Lys Pro 
305                 310                 315                 320 


Glu Gly Trp Leu Asp Asp Glu Pro Glu Tyr Val Pro Asp Pro Asp Ala 
                325                 330                 335     


Glu Lys Pro Glu Asp Trp Asp Glu Asp Met Asp Gly Glu Trp Glu Ala 
            340                 345                 350         


Pro Gln Ile Ala Asn Pro Arg Cys Glu Ser Ala Pro Gly Cys Gly Val 
        355                 360                 365             


Trp Gln Arg Pro Val Ile Asp Asn Pro Asn Tyr Lys Gly Lys Trp Lys 
    370                 375                 380                 


Pro Pro Met Ile Asp Asn Pro Ser Tyr Gln Gly Ile Trp Lys Pro Arg 
385                 390                 395                 400 


Lys Ile Pro Asn Pro Asp Phe Phe Glu Asp Leu Glu Pro Phe Arg Met 
                405                 410                 415     


Thr Pro Phe Ser Ala Ile Gly Leu Glu Leu Trp Ser Met Thr Ser Asp 
            420                 425                 430         


Ile Phe Phe Asp Asn Phe Ile Ile Cys Ala Asp Arg Arg Ile Val Asp 
        435                 440                 445             


Asp Trp Ala Asn Asp Gly Trp Gly Leu Lys Lys Ala Ala Asp Gly Ala 
    450                 455                 460                 


Ala Glu Pro Gly Val Val Gly Gln Met Ile Glu Ala Ala Glu Glu Arg 
465                 470                 475                 480 


Pro Trp Leu Trp Val Val Tyr Ile Leu Thr Val Ala Leu Pro Val Phe 
                485                 490                 495     


Leu Val Ile Leu Phe Cys Cys Ser Gly Lys Lys Gln Thr Ser Gly Met 
            500                 505                 510         


Glu Tyr Lys Lys Thr Asp Ala Pro Gln Pro Asp Val Lys Glu Glu Glu 
        515                 520                 525             


Glu Glu Lys Glu Glu Glu Lys Asp Lys Gly Asp Glu Glu Glu Glu Gly 
    530                 535                 540                 


Glu Glu Lys Leu Glu Glu Lys Gln Lys Ser Asp Ala Glu Glu Asp Gly 
545                 550                 555                 560 


Gly Thr Val Ser Gln Glu Glu Glu Asp Arg Lys Pro Lys Ala Glu Glu 
                565                 570                 575     


Asp Glu Ile Leu Asn Arg Ser Pro Arg Asn Arg Lys Pro Arg Arg Glu 
            580                 585                 590         


<210>  2047
<211>  308
<212>  PRT
<213>  Homo Sapiens

<400>  2047

Met Glu Gly Lys Trp Leu Leu Cys Met Leu Leu Val Leu Gly Thr Ala 
1               5                   10                  15      


Ile Val Glu Ala His Asp Gly His Asp Asp Asp Val Ile Asp Ile Glu 
            20                  25                  30          


Asp Asp Leu Asp Asp Val Ile Glu Glu Val Glu Glu Met Lys Glu Ser 
        35                  40                  45              


Lys Leu Pro Gly Asp Lys Gly Leu Val Leu Met Ser Arg Ala Lys His 
    50                  55                  60                  


His Ala Ile Ser Ala Lys Leu Asn Lys Pro Phe Leu Phe Asp Thr Lys 
65                  70                  75                  80  


Pro Leu Ile Val Gln Tyr Glu Val Asn Phe Gln Asn Gly Ile Glu Cys 
                85                  90                  95      


Gly Gly Ala Tyr Val Lys Leu Leu Ser Lys Thr Pro Glu Leu Asn Leu 
            100                 105                 110         


Asp Gln Phe His Asp Lys Thr Pro Tyr Thr Ile Met Phe Gly Pro Asp 
        115                 120                 125             


Lys Cys Gly Glu Asp Tyr Lys Leu His Phe Ile Phe Arg His Lys Asn 
    130                 135                 140                 


Pro Lys Thr Gly Ile Tyr Glu Glu Lys His Ala Lys Arg Pro Asp Ala 
145                 150                 155                 160 


Asp Leu Lys Thr Tyr Phe Thr Asp Lys Lys Thr His Leu Tyr Thr Leu 
                165                 170                 175     


Ile Leu Asn Pro Asp Asn Ser Phe Glu Ile Leu Val Asp Gln Ser Val 
            180                 185                 190         


Val Asn Ser Gly Asn Leu Leu Asn Asp Met Thr Pro Pro Val Asn Pro 
        195                 200                 205             


Ser Arg Glu Ile Glu Asp Pro Glu Asp Arg Lys Pro Glu Asp Trp Asp 
    210                 215                 220                 


Glu Arg Pro Lys Ile Pro Asp Pro Glu Ala Val Lys Pro Asp Asp Trp 
225                 230                 235                 240 


Asp Glu Asp Ala Pro Ala Lys Ile Pro Asp Glu Glu Ala Thr Lys Pro 
                245                 250                 255     


Glu Gly Trp Leu Asp Asp Glu Pro Glu Tyr Val Pro Asp Pro Asp Ala 
            260                 265                 270         


Glu Lys Pro Glu Asp Trp Asp Glu Asp Met Asp Gly Glu Trp Glu Ala 
        275                 280                 285             


Pro Gln Ile Ala Asn Pro Arg Cys Glu Ser Ala Pro Gly Cys Gly Val 
    290                 295                 300                 


Trp Gln Arg Pro 
305             


<210>  2048
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  2048

Met Lys Glu Ser Lys Leu Pro Gly Asp Lys Gly Leu Val Leu Met Ser 
1               5                   10                  15      


Arg Ala Lys His His Ala Ile Ser Ala Lys Leu Asn Lys Pro Phe Leu 
            20                  25                  30          


Phe Asp Thr Lys Pro Leu Ile Val Gln Tyr Glu Val Asn Phe Gln Asn 
        35                  40                  45              


Gly Ile Glu Cys Gly Gly Ala Tyr Val Lys Leu Leu Ser Lys Thr Pro 
    50                  55                  60                  


Glu Leu Asn Leu Asp Gln Phe His Asp Lys Thr Pro Tyr Thr Ile Met 
65                  70                  75                  80  


Phe Gly Pro Asp Lys Cys Gly Glu Asp Tyr Lys Leu His Phe Ile Phe 
                85                  90                  95      


Arg His Lys Asn Pro Lys Thr Gly Ile Tyr Glu Glu Lys His Ala Lys 
            100                 105                 110         


Arg Pro Asp Ala Asp Leu Lys Thr Tyr Phe Thr Asp Lys Lys Thr His 
        115                 120                 125             


Leu Tyr Thr 
    130     


<210>  2049
<211>  190
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2049

Xaa Gly Leu Val Leu Met Ser Arg Ala Lys His His Ala Ile Ser Ala 
1               5                   10                  15      


Lys Leu Asn Lys Pro Phe Leu Phe Asp Thr Lys Pro Leu Ile Val Gln 
            20                  25                  30          


Tyr Glu Val Asn Phe Gln Asn Gly Ile Glu Cys Gly Gly Ala Tyr Val 
        35                  40                  45              


Lys Leu Leu Ser Lys Thr Pro Glu Leu Asn Leu Asp Gln Phe His Asp 
    50                  55                  60                  


Lys Thr Pro Tyr Thr Ile Met Phe Gly Pro Asp Lys Cys Gly Glu Asp 
65                  70                  75                  80  


Tyr Lys Leu His Phe Ile Phe Arg His Lys Asn Pro Lys Thr Gly Ile 
                85                  90                  95      


Tyr Glu Glu Lys His Ala Lys Arg Pro Asp Ala Asp Leu Lys Thr Tyr 
            100                 105                 110         


Phe Thr Asp Lys Lys Thr His Leu Tyr Thr Leu Lys Ser Arg Gly Thr 
        115                 120                 125             


Asn His Leu Cys Phe Val His Lys Glu Met Gly Val Ser Phe Pro Lys 
    130                 135                 140                 


Thr Pro Gly Ala Arg His Cys Ser Tyr Pro Lys Ala Ser Val Leu Asn 
145                 150                 155                 160 


Pro Asp Asn Ser Phe Glu Ile Leu Val Asp Gln Ser Val Val Asn Ser 
                165                 170                 175     


Gly Asn Leu Leu Asn Asp Met Thr Pro Pro Val Asn Pro Ser 
            180                 185                 190 


<210>  2050
<211>  170
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2050

Xaa Leu Tyr Cys Gly Ala Gly Gln Gly Val Arg Ala Gly Arg Gly Thr 
1               5                   10                  15      


Gly Thr Pro Ala Val Pro Gly Arg Leu Glu Val Thr Tyr Lys Ala Pro 
            20                  25                  30          


Val Pro Thr Gly Glu Val Tyr Phe Ala Asp Ser Phe Asp Arg Gly Thr 
        35                  40                  45              


Leu Ser Gly Trp Ile Leu Ser Lys Ala Lys Lys Asp Asp Thr Asp Asp 
    50                  55                  60                  


Glu Ile Ala Lys Tyr Asp Gly Lys Trp Glu Val Glu Glu Met Lys Glu 
65                  70                  75                  80  


Ser Lys Leu Pro Gly Asp Lys Gly Leu Val Leu Met Ser Arg Ala Lys 
                85                  90                  95      


His His Ala Ile Ser Ala Lys Leu Asn Lys Pro Phe Leu Phe Asp Thr 
            100                 105                 110         


Lys Pro Leu Ile Val Gln Tyr Glu Val Asn Phe Gln Asn Gly Ile Glu 
        115                 120                 125             


Cys Gly Gly Ala Tyr Val Lys Leu Leu Ser Lys Thr Pro Glu Leu Asn 
    130                 135                 140                 


Leu Asp Gln Phe His Asp Lys Thr Pro Tyr Thr Ile Met Phe Gly Pro 
145                 150                 155                 160 


Asp Lys Cys Gly Glu Asp Tyr Lys Leu His 
                165                 170 


<210>  2051
<211>  111
<212>  PRT
<213>  Homo Sapiens

<400>  2051

Ala Glu Gln Gln Ala Leu Arg Leu Glu Val Arg Ala Gly Pro Asp Ser 
1               5                   10                  15      


Ala Gly Ile Ala Leu Tyr Ser His Glu Asp Val Cys Val Phe Lys Cys 
            20                  25                  30          


Ser Val Ser Arg Glu Thr Glu Cys Ser Arg Val Gly Lys Gln Ser Phe 
        35                  40                  45              


Ile Ile Thr Leu Gly Cys Asn Ser Val Leu Ile Gln Phe Ala Thr Pro 
    50                  55                  60                  


Asn Asp Phe Cys Ser Phe Tyr Asn Ile Leu Lys Thr Cys Arg Gly His 
65                  70                  75                  80  


Thr Leu Glu Arg Ser Val Phe Ser Glu Arg Thr Glu Glu Ser Ser Ala 
                85                  90                  95      


Val Gln Tyr Phe Gln Met Arg Lys Leu Arg Leu Arg Glu Val Lys 
            100                 105                 110     


<210>  2052
<211>  92
<212>  PRT
<213>  Homo Sapiens

<400>  2052

Ala Leu Tyr Ser His Glu Asp Val Cys Val Phe Lys Cys Ser Val Ser 
1               5                   10                  15      


Arg Glu Thr Glu Cys Ser Arg Val Gly Lys Gln Ser Phe Ile Ile Thr 
            20                  25                  30          


Leu Gly Cys Asn Ser Val Leu Ile Gln Phe Ala Thr Pro Asn Asp Phe 
        35                  40                  45              


Cys Ser Phe Tyr Asn Ile Leu Lys Thr Cys Arg Gly His Thr Leu Glu 
    50                  55                  60                  


Arg Ser Val Phe Ser Glu Arg Thr Glu Glu Ser Ser Ala Val Gln Tyr 
65                  70                  75                  80  


Phe Gln Met Arg Lys Leu Arg Leu Arg Glu Val Lys 
                85                  90          


<210>  2053
<211>  176
<212>  PRT
<213>  Homo Sapiens

<400>  2053

Leu Ala Phe Trp Phe Asp Val Ala Phe Ile Gly Ser Ile Gln Ser Tyr 
1               5                   10                  15      


Asp Ile Ser Ile Val Ala Gln Val Asp Gln Thr Gly Ser Lys Ser Ser 
            20                  25                  30          


Asn Leu Leu Asp Leu Lys Asn Pro Phe Phe Arg Tyr Thr Gly Thr Thr 
        35                  40                  45              


Pro Ser Pro Pro Pro Gly Ser His Tyr Thr Ser Pro Ser Glu Asn Met 
    50                  55                  60                  


Trp Asn Thr Gly Ser Thr Tyr Asn Leu Ser Ser Gly Met Ala Val Ala 
65                  70                  75                  80  


Gly Met Pro Thr Ala Tyr Asp Leu Ser Ser Val Ile Ala Ser Gly Ser 
                85                  90                  95      


Ser Val Gly His Asn Asn Leu Ile Pro Leu Ala Asn Thr Gly Ile Val 
            100                 105                 110         


Asn His Thr His Ser Arg Met Gly Ser Ile Met Ser Thr Gly Ile Val 
        115                 120                 125             


Gln Gly Ser Ser Gly Ala Gln Gly Ser Gly Gly Gly Ser Thr Ser Ala 
    130                 135                 140                 


His Tyr Ala Val Asn Ser Gln Phe Thr Met Gly Gly Pro Ala Ile Ser 
145                 150                 155                 160 


Met Ala Ser Pro Met Ser Ile Pro Thr Asn Thr Met His Tyr Gly Ser 
                165                 170                 175     


<210>  2054
<211>  608
<212>  PRT
<213>  Homo Sapiens

<400>  2054

Met Ala Ala Ala Ala Ala Ala Val Gly Pro Gly Ala Gly Gly Ala Gly 
1               5                   10                  15      


Ser Ala Val Pro Gly Gly Ala Gly Pro Cys Ala Thr Val Ser Val Phe 
            20                  25                  30          


Pro Gly Ala Arg Leu Leu Thr Ile Gly Asp Ala Asn Gly Glu Ile Gln 
        35                  40                  45              


Arg His Ala Glu Gln Gln Ala Leu Arg Leu Glu Val Arg Ala Gly Pro 
    50                  55                  60                  


Asp Ser Ala Gly Ile Ala Leu Tyr Ser His Glu Asp Val Cys Val Phe 
65                  70                  75                  80  


Lys Cys Ser Val Ser Arg Glu Thr Glu Cys Ser Arg Val Gly Lys Gln 
                85                  90                  95      


Ser Phe Ile Ile Thr Leu Gly Cys Asn Ser Val Leu Ile Gln Phe Ala 
            100                 105                 110         


Thr Pro Asn Asp Phe Cys Ser Phe Tyr Asn Ile Leu Lys Thr Cys Arg 
        115                 120                 125             


Gly His Thr Leu Glu Arg Ser Val Phe Ser Glu Arg Thr Glu Glu Ser 
    130                 135                 140                 


Ser Ala Val Gln Tyr Phe Gln Phe Tyr Gly Tyr Leu Ser Gln Gln Gln 
145                 150                 155                 160 


Asn Met Met Gln Asp Tyr Val Arg Thr Gly Thr Tyr Gln Arg Ala Ile 
                165                 170                 175     


Leu Gln Asn His Thr Asp Phe Lys Asp Lys Ile Val Leu Asp Val Gly 
            180                 185                 190         


Cys Gly Ser Gly Ile Leu Ser Phe Phe Ala Ala Gln Ala Gly Ala Arg 
        195                 200                 205             


Lys Ile Tyr Ala Val Glu Ala Ser Thr Met Ala Gln His Ala Glu Val 
    210                 215                 220                 


Leu Val Lys Ser Asn Asn Leu Thr Asp Arg Ile Val Val Ile Pro Gly 
225                 230                 235                 240 


Lys Val Glu Glu Val Ser Leu Pro Glu Gln Val Asp Ile Ile Ile Ser 
                245                 250                 255     


Glu Pro Met Gly Tyr Met Leu Phe Asn Glu Arg Met Leu Glu Ser Tyr 
            260                 265                 270         


Leu His Ala Lys Lys Tyr Leu Lys Pro Ser Gly Asn Met Phe Pro Thr 
        275                 280                 285             


Ile Gly Asp Val His Leu Ala Pro Phe Thr Asp Glu Gln Leu Tyr Met 
    290                 295                 300                 


Glu Gln Phe Thr Lys Ala Asn Phe Trp Tyr Gln Pro Ser Phe His Gly 
305                 310                 315                 320 


Val Asp Leu Ser Ala Leu Arg Gly Ala Ala Val Asp Glu Tyr Phe Arg 
                325                 330                 335     


Gln Pro Val Val Asp Thr Phe Asp Ile Arg Ile Leu Met Ala Lys Ser 
            340                 345                 350         


Val Lys Tyr Thr Val Asn Phe Leu Glu Ala Lys Glu Gly Asp Leu His 
        355                 360                 365             


Arg Ile Glu Ile Pro Phe Lys Phe His Met Leu His Ser Gly Leu Val 
    370                 375                 380                 


His Gly Leu Ala Phe Trp Phe Asp Val Ala Phe Ile Gly Ser Ile Met 
385                 390                 395                 400 


Thr Val Trp Leu Ser Thr Ala Pro Thr Glu Pro Leu Thr His Trp Tyr 
                405                 410                 415     


Gln Val Arg Cys Leu Phe Gln Ser Pro Leu Phe Ala Lys Ala Gly Asp 
            420                 425                 430         


Thr Leu Ser Gly Thr Cys Leu Leu Ile Ala Asn Lys Arg Gln Ser Tyr 
        435                 440                 445             


Asp Ile Ser Ile Val Ala Gln Val Asp Gln Thr Gly Ser Lys Ser Ser 
    450                 455                 460                 


Asn Leu Leu Asp Leu Lys Asn Pro Phe Phe Arg Tyr Thr Gly Thr Thr 
465                 470                 475                 480 


Pro Ser Pro Pro Pro Gly Ser His Tyr Thr Ser Pro Ser Glu Asn Met 
                485                 490                 495     


Trp Asn Thr Gly Ser Thr Tyr Asn Leu Ser Ser Gly Met Ala Val Ala 
            500                 505                 510         


Gly Met Pro Thr Ala Tyr Asp Leu Ser Ser Val Ile Ala Ser Gly Ser 
        515                 520                 525             


Ser Val Gly His Asn Asn Leu Ile Pro Leu Ala Asn Thr Gly Ile Val 
    530                 535                 540                 


Asn His Thr His Ser Arg Met Gly Ser Ile Met Ser Thr Gly Ile Val 
545                 550                 555                 560 


Gln Gly Ser Ser Gly Ala Gln Gly Ser Gly Gly Gly Ser Thr Ser Ala 
                565                 570                 575     


His Tyr Ala Val Asn Ser Gln Phe Thr Met Gly Gly Pro Ala Ile Ser 
            580                 585                 590         


Met Ala Ser Pro Met Ser Ile Pro Thr Asn Thr Met His Tyr Gly Ser 
        595                 600                 605             


<210>  2055
<211>  585
<212>  PRT
<213>  Homo Sapiens

<400>  2055

Met Ala Ala Ala Ala Ala Ala Val Gly Pro Gly Ala Gly Gly Ala Gly 
1               5                   10                  15      


Ser Ala Val Pro Gly Gly Ala Gly Pro Cys Ala Thr Val Ser Val Phe 
            20                  25                  30          


Pro Gly Ala Arg Leu Leu Thr Ile Gly Asp Ala Asn Gly Glu Ile Gln 
        35                  40                  45              


Arg His Ala Glu Gln Gln Ala Leu Arg Leu Glu Val Arg Ala Gly Pro 
    50                  55                  60                  


Asp Ser Ala Gly Ile Ala Leu Tyr Ser His Glu Asp Val Cys Val Phe 
65                  70                  75                  80  


Lys Cys Ser Val Ser Arg Glu Thr Glu Cys Ser Arg Val Gly Lys Gln 
                85                  90                  95      


Ser Phe Ile Ile Thr Leu Gly Cys Asn Ser Val Leu Ile Gln Phe Ala 
            100                 105                 110         


Thr Pro Asn Asp Phe Cys Ser Phe Tyr Asn Ile Leu Lys Thr Cys Arg 
        115                 120                 125             


Gly His Thr Leu Glu Arg Ser Val Phe Ser Glu Arg Thr Glu Glu Ser 
    130                 135                 140                 


Ser Ala Val Gln Tyr Phe Gln Phe Tyr Gly Tyr Leu Ser Gln Gln Gln 
145                 150                 155                 160 


Asn Met Met Gln Asp Tyr Val Arg Thr Gly Thr Tyr Gln Arg Ala Ile 
                165                 170                 175     


Leu Gln Asn His Thr Asp Phe Lys Asp Lys Ile Val Leu Asp Val Gly 
            180                 185                 190         


Cys Gly Ser Gly Ile Leu Ser Phe Phe Ala Ala Gln Ala Gly Ala Arg 
        195                 200                 205             


Lys Ile Tyr Ala Val Glu Ala Ser Thr Met Ala Gln His Ala Glu Val 
    210                 215                 220                 


Leu Val Lys Ser Asn Asn Leu Thr Asp Arg Ile Val Val Ile Pro Gly 
225                 230                 235                 240 


Lys Val Glu Glu Val Ser Leu Pro Glu Gln Val Asp Ile Ile Ile Ser 
                245                 250                 255     


Glu Pro Met Gly Tyr Met Leu Phe Asn Glu Arg Met Leu Glu Ser Tyr 
            260                 265                 270         


Leu His Ala Lys Lys Tyr Leu Lys Pro Ser Gly Asn Met Phe Pro Thr 
        275                 280                 285             


Ile Gly Asp Val His Leu Ala Pro Phe Thr Asp Glu Gln Leu Tyr Met 
    290                 295                 300                 


Glu Gln Phe Thr Lys Ala Asn Phe Trp Tyr Gln Pro Ser Phe His Gly 
305                 310                 315                 320 


Val Asp Leu Ser Ala Leu Arg Gly Ala Ala Val Asp Glu Tyr Phe Arg 
                325                 330                 335     


Gln Pro Val Val Asp Thr Phe Asp Ile Arg Ile Leu Met Ala Lys Ser 
            340                 345                 350         


Val Lys Tyr Thr Val Asn Phe Leu Glu Ala Lys Glu Gly Asp Leu His 
        355                 360                 365             


Arg Ile Glu Ile Pro Phe Lys Phe His Met Leu His Ser Gly Leu Val 
    370                 375                 380                 


His Gly Leu Ala Phe Trp Phe Asp Val Ala Phe Ile Gly Ser Ile Met 
385                 390                 395                 400 


Thr Val Trp Leu Ser Thr Ala Pro Thr Glu Pro Leu Thr His Trp Tyr 
                405                 410                 415     


Gln Val Arg Cys Leu Phe Gln Ser Pro Leu Phe Ala Lys Ala Gly Asp 
            420                 425                 430         


Thr Leu Ser Gly Thr Cys Leu Leu Ile Ala Asn Lys Arg Gln Ser Tyr 
        435                 440                 445             


Asp Ile Ser Ile Val Ala Gln Val Asp Gln Thr Gly Ser Lys Ser Ser 
    450                 455                 460                 


Asn Leu Leu Asp Leu Lys Asn Pro Phe Phe Arg Tyr Thr Gly Thr Thr 
465                 470                 475                 480 


Pro Ser Pro Pro Pro Gly Ser His Tyr Thr Ser Pro Ser Glu Asn Met 
                485                 490                 495     


Trp Asn Thr Gly Ser Thr Tyr Asn Leu Ser Ser Gly Met Ala Val Ala 
            500                 505                 510         


Gly Met Pro Thr Ala Tyr Asp Leu Ser Ser Val Ile Ala Ser Gly Ser 
        515                 520                 525             


Ser Val Gly His Asn Asn Leu Ile Pro Leu Gly Ser Ser Gly Ala Gln 
    530                 535                 540                 


Gly Ser Gly Gly Gly Ser Thr Ser Ala His Tyr Ala Val Asn Ser Gln 
545                 550                 555                 560 


Phe Thr Met Gly Gly Pro Ala Ile Ser Met Ala Ser Pro Met Ser Ile 
                565                 570                 575     


Pro Thr Asn Thr Met His Tyr Gly Ser 
            580                 585 


<210>  2056
<211>  161
<212>  PRT
<213>  Homo Sapiens

<400>  2056

Met Ala Ala Ala Ala Ala Ala Val Gly Pro Gly Ala Gly Gly Ala Gly 
1               5                   10                  15      


Ser Ala Val Pro Gly Gly Ala Gly Pro Cys Ala Thr Val Ser Val Phe 
            20                  25                  30          


Pro Gly Ala Arg Leu Leu Thr Ile Gly Asp Ala Asn Gly Glu Ile Gln 
        35                  40                  45              


Arg His Ala Glu Gln Gln Ala Leu Arg Leu Glu Val Arg Ala Gly Pro 
    50                  55                  60                  


Asp Ser Ala Gly Ile Ala Leu Tyr Ser His Glu Asp Val Cys Val Phe 
65                  70                  75                  80  


Lys Cys Ser Val Ser Arg Glu Thr Glu Cys Ser Arg Val Gly Lys Gln 
                85                  90                  95      


Ser Phe Ile Ile Thr Leu Gly Cys Asn Ser Val Leu Ile Gln Phe Ala 
            100                 105                 110         


Thr Pro Asn Asp Phe Cys Ser Phe Tyr Asn Ile Leu Lys Thr Cys Arg 
        115                 120                 125             


Gly His Thr Leu Glu Arg Ser Val Phe Ser Glu Arg Thr Glu Glu Ser 
    130                 135                 140                 


Ser Ala Val Gln Tyr Phe Gln Met Arg Lys Leu Arg Leu Arg Glu Val 
145                 150                 155                 160 


Lys 
    


<210>  2057
<211>  120
<212>  PRT
<213>  Homo Sapiens

<400>  2057

Met Ala Ala Ala Ala Ala Ala Val Gly Pro Gly Ala Gly Gly Ala Gly 
1               5                   10                  15      


Ser Ala Val Pro Gly Gly Ala Gly Pro Cys Ala Thr Val Ser Val Phe 
            20                  25                  30          


Pro Gly Ala Arg Leu Leu Thr Ile Gly Asp Ala Asn Gly Glu Ile Gln 
        35                  40                  45              


Arg His Ala Glu Gln Gln Ala Leu Arg Leu Glu Val Arg Ala Gly Pro 
    50                  55                  60                  


Asp Ser Ala Gly Ile Ala Leu Tyr Ser His Phe Cys Ser Phe Tyr Asn 
65                  70                  75                  80  


Ile Leu Lys Thr Cys Arg Gly His Thr Leu Glu Arg Ser Val Phe Ser 
                85                  90                  95      


Glu Arg Thr Glu Glu Ser Ser Ala Val Gln Tyr Phe Gln Phe Tyr Gly 
            100                 105                 110         


Tyr Leu Ser Gln Gln Gln Asn Met 
        115                 120 


<210>  2058
<211>  343
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2058

Xaa Ala Asn Gly Glu Ile Gln Arg His Ala Glu Gln Gln Ala Leu Arg 
1               5                   10                  15      


Leu Glu Val Arg Ala Gly Pro Asp Ser Ala Gly Ile Ala Leu Tyr Ser 
            20                  25                  30          


His Glu Asp Val Cys Val Phe Lys Cys Ser Val Ser Arg Glu Thr Glu 
        35                  40                  45              


Cys Ser Arg Val Gly Lys Gln Ser Phe Ile Ile Thr Leu Gly Cys Asn 
    50                  55                  60                  


Ser Val Leu Ile Gln Phe Ala Thr Pro Asn Asp Phe Cys Ser Phe Tyr 
65                  70                  75                  80  


Asn Ile Leu Lys Thr Cys Arg Gly His Thr Leu Glu Arg Ser Val Phe 
                85                  90                  95      


Ser Glu Arg Thr Glu Glu Ser Ser Ala Val Gln Tyr Phe Gln Phe Tyr 
            100                 105                 110         


Gly Tyr Leu Ser Gln Gln Gln Asn Met Met Gln Asp Tyr Val Arg Thr 
        115                 120                 125             


Gly Thr Tyr Gln Arg Ala Ile Leu Gln Asn His Thr Asp Phe Lys Asp 
    130                 135                 140                 


Lys Ile Val Leu Asp Val Gly Cys Gly Ser Gly Ile Leu Ser Phe Phe 
145                 150                 155                 160 


Ala Ala Gln Ala Gly Ala Arg Lys Ile Tyr Ala Val Glu Ala Ser Thr 
                165                 170                 175     


Met Ala Gln His Ala Glu Val Leu Val Lys Ser Asn Asn Leu Thr Asp 
            180                 185                 190         


Arg Ile Val Val Ile Pro Gly Lys Val Glu Glu Val Ser Leu Pro Glu 
        195                 200                 205             


Gln Val Asp Ile Ile Ile Ser Glu Pro Met Gly Tyr Met Leu Phe Asn 
    210                 215                 220                 


Glu Arg Met Leu Glu Ser Tyr Leu His Ala Lys Lys Tyr Leu Lys Pro 
225                 230                 235                 240 


Ser Gly Asn Met Phe Pro Thr Ile Gly Asp Val His Leu Ala Pro Phe 
                245                 250                 255     


Thr Asp Glu Gln Leu Tyr Met Glu Gln Phe Thr Lys Ala Asn Phe Trp 
            260                 265                 270         


Tyr Gln Pro Ser Phe His Gly Val Asp Leu Ser Ala Leu Arg Gly Ala 
        275                 280                 285             


Ala Val Asp Glu Tyr Phe Arg Gln Pro Val Val Asp Thr Phe Asp Ile 
    290                 295                 300                 


Arg Ile Leu Met Ala Lys Ser Val Lys Tyr Thr Val Asn Phe Leu Glu 
305                 310                 315                 320 


Ala Lys Glu Gly Asp Leu His Ser Ala Cys Leu Ala Ser Pro Ala Ala 
                325                 330                 335     


Thr Ala Leu Cys Leu Pro Gly 
            340             


<210>  2059
<211>  827
<212>  PRT
<213>  Homo Sapiens

<400>  2059

Met Leu Leu Cys Leu Ser Pro Ala Trp Leu Met Lys Val Pro Ala Pro 
1               5                   10                  15      


Gly Gln Pro Gly Glu Ala Ala Leu Leu Val Ser Lys Ala Val Ser Phe 
            20                  25                  30          


His Pro Gly Gly Leu Thr Phe Leu Asp Asp Phe Val Pro Pro Arg Arg 
        35                  40                  45              


Ala Thr Tyr Phe Leu Ala Gly Leu Gly Leu Gly Pro Gly Arg Gly Arg 
    50                  55                  60                  


Glu Ala Ala Glu Leu Ala Arg Asp Leu Thr Cys Pro Thr Gly Ala Ser 
65                  70                  75                  80  


Ala Glu Leu Ala Arg Leu Leu Glu Asp Arg Leu Leu Thr Arg Gln Leu 
                85                  90                  95      


Leu Ala Gln Gln Gly Gly Val Ala Val Pro Ala Thr Leu Ala Phe Thr 
            100                 105                 110         


Tyr Lys Pro Pro Gly Leu Leu Arg Gly Gly Asp Ala Ser Leu Gly Leu 
        115                 120                 125             


Arg Leu Val Glu Leu Ser Gly Lys Glu Gly Gln Glu Thr Leu Val Lys 
    130                 135                 140                 


Glu Glu Val Glu Ala Phe Leu Arg Ser Glu Ala Leu Gly Asp Ile Leu 
145                 150                 155                 160 


Gln Val Ala Val Lys Leu Ser Gly Trp Arg Trp Arg Gly Arg Gln Ala 
                165                 170                 175     


Trp Arg Leu His Pro Arg Ala Glu Leu Gly Ala Val Val Asp Thr Val 
            180                 185                 190         


Leu Ala Leu Leu Glu Lys Leu Glu Glu Glu Glu Ser Val Leu Val Glu 
        195                 200                 205             


Ala Val Tyr Pro Pro Ala Gln Leu Pro Cys Ser Asp Gly Pro Ser Pro 
    210                 215                 220                 


Gly Pro Gly Leu Ala Val Arg Ile Cys Ala Val Val Cys Arg Thr Gln 
225                 230                 235                 240 


Gly Asp Arg Pro Leu Leu Ser Lys Val Val Cys Gly Val Gly Arg Gly 
                245                 250                 255     


Asp Arg Pro Leu Arg His His Asn Ser Leu Pro Arg Thr Leu Glu Val 
            260                 265                 270         


Ala Leu Ala Gln Cys Gly Leu Gly Glu Glu Ala Gln Val Ala Ala Val 
        275                 280                 285             


Arg Gln Arg Val Lys Ala Ala Ala Glu Ala Ala Leu Ala Ala Val Leu 
    290                 295                 300                 


Ala Leu Glu Ala Gly Leu Ser Ala Glu Gln Arg Gly Gly Arg Arg Ala 
305                 310                 315                 320 


His Thr Asp Phe Leu Gly Val Asp Phe Ala Leu Thr Ala Ala Gly Gly 
                325                 330                 335     


Val Leu Thr Pro Val Ala Leu Glu Leu Asn Gly Gly Leu Cys Leu Glu 
            340                 345                 350         


Ala Cys Gly Ala Leu Glu Gly Leu Trp Ala Ala Pro Arg Leu Gly Pro 
        355                 360                 365             


Ala Ala Asp Glu Ala Val Ala Ala Pro Leu Val Glu Thr Met Leu Arg 
    370                 375                 380                 


Arg Ser Ala Arg Cys Leu Met Glu Gly Lys Gln Leu Leu Val Val Gly 
385                 390                 395                 400 


Ala Gly Gly Val Ser Lys Lys Phe Val Trp Glu Ala Ala Arg Asp Tyr 
                405                 410                 415     


Gly Leu Gln Leu His Leu Val Glu Ser Asp Pro Asn His Phe Ala Ser 
            420                 425                 430         


Gln Leu Val Gln Thr Phe Ile His Phe Asp Met Thr Glu His Arg Arg 
        435                 440                 445             


Asp Glu Glu Asn Ala Arg Leu Leu Ala Glu Leu Val Arg Ala Arg Gly 
    450                 455                 460                 


Leu Lys Leu Asp Gly Cys Phe Ser Tyr Trp Asp Asp Cys Leu Val Leu 
465                 470                 475                 480 


Thr Ala Leu Leu Cys Gln Glu Leu Gly Leu Pro Cys Ser Ser Pro Ala 
                485                 490                 495     


Ala Met Arg Leu Ala Lys Gln Lys Ser Leu Thr Gln Leu His Leu Leu 
            500                 505                 510         


His His His Gly Pro Pro Trp Pro Ala Pro Ser Leu His Ala Val Pro 
        515                 520                 525             


Cys Cys Pro Leu Glu Ser Glu Ala Asp Val Glu Arg Ala Val His Gln 
    530                 535                 540                 


Val Pro Leu Pro Gly Val Met Lys Leu Glu Phe Gly Ala Gly Ala Val 
545                 550                 555                 560 


Gly Val Arg Leu Val Glu Asp Ala Pro Gln Cys His Glu His Phe Ser 
                565                 570                 575     


Arg Ile Thr Arg Asp Leu Gln Gly Glu Ala Asp His Pro Gly Ile Gly 
            580                 585                 590         


Leu Gly Trp Gly Asn Ala Met Leu Leu Met Glu Phe Val Glu Gly Thr 
        595                 600                 605             


Glu His Asp Val Asp Leu Val Leu Phe Gly Gly Arg Leu Leu Ala Ala 
    610                 615                 620                 


Phe Val Ser Asp Asn Gly Pro Thr Arg Leu Pro Gly Phe Thr Glu Thr 
625                 630                 635                 640 


Ala Ala Cys Met Pro Thr Gly Leu Ala Pro Glu Gln Glu Ala Gln Met 
                645                 650                 655     


Val Gln Ala Ala Phe Arg Cys Cys Leu Gly Cys Gly Leu Leu Asp Gly 
            660                 665                 670         


Val Phe Asn Val Glu Leu Lys Leu Thr Gly Ala Gly Pro Arg Leu Ile 
        675                 680                 685             


Glu Ile Asn Pro Arg Met Gly Gly Phe Tyr Leu Arg Asp Trp Ile Leu 
    690                 695                 700                 


Glu Leu Tyr Gly Val Asp Leu Leu Leu Ala Ala Val Met Val Ala Cys 
705                 710                 715                 720 


Gly Leu Arg Pro Ala Leu Pro Thr Arg Pro Arg Ala Arg Gly His Leu 
                725                 730                 735     


Val Gly Val Met Cys Leu Val Ser Gln His Leu Gln Ala Leu Ser Ser 
            740                 745                 750         


Thr Ala Ser Arg Glu Thr Leu Gln Ala Leu His Asp Arg Gly Leu Leu 
        755                 760                 765             


Arg Leu Asn Leu Leu Glu Glu Ala Leu Val Pro Gly Glu Tyr Glu Glu 
    770                 775                 780                 


Pro Tyr Cys Ser Val Ala Cys Ala Gly Pro Ser Pro Thr Glu Ala Arg 
785                 790                 795                 800 


Leu Arg Leu Leu Gly Leu Cys Gln Gly Leu Gly Ile Asp Gly Pro Ser 
                805                 810                 815     


Tyr Pro Val Ala His Phe Leu Ser His Phe Lys 
            820                 825         


<210>  2060
<211>  950
<212>  PRT
<213>  Homo Sapiens

<400>  2060

Met Leu Ser Leu Asp Pro Ser Gly Pro Glu Trp Asp Cys Pro Leu Gly 
1               5                   10                  15      


Ser Lys Asp Leu Glu Glu Glu Gly Pro Trp Gly Gly Gly Ser Gly Leu 
            20                  25                  30          


Pro Pro Thr Gly Cys Phe Pro Gly Ser Trp Arg Gln Asp Val Gly Leu 
        35                  40                  45              


Asp Cys Lys Gly Ser Pro Glu Gly Ala Glu Ala Arg Ala Trp Thr Val 
    50                  55                  60                  


Tyr Tyr Tyr Ser Leu Leu Gln Ser Cys Leu Gln Gln Ala Gly Leu Pro 
65                  70                  75                  80  


Glu Thr Gln Asp Arg Gly Gln Val Pro Arg Thr Gly Cys Pro Gly Ala 
                85                  90                  95      


Glu Val Thr Leu Cys Val Leu Gly Ser Pro Ser Thr Phe Leu Pro Val 
            100                 105                 110         


Leu Leu Glu Gly Gly Val Gln Ser Pro Gly Asn Met Leu Leu Cys Leu 
        115                 120                 125             


Ser Pro Ala Trp Leu Met Lys Val Pro Ala Pro Gly Gln Pro Gly Glu 
    130                 135                 140                 


Ala Ala Leu Leu Val Ser Lys Ala Val Ser Phe His Pro Gly Gly Leu 
145                 150                 155                 160 


Thr Phe Leu Asp Asp Phe Val Pro Pro Arg Arg Ala Thr Tyr Phe Leu 
                165                 170                 175     


Ala Gly Leu Gly Leu Gly Pro Gly Arg Gly Arg Glu Ala Ala Glu Leu 
            180                 185                 190         


Ala Arg Asp Leu Thr Cys Pro Thr Gly Ala Ser Ala Glu Leu Ala Arg 
        195                 200                 205             


Leu Leu Glu Asp Arg Leu Leu Thr Arg Gln Leu Leu Ala Gln Gln Gly 
    210                 215                 220                 


Gly Val Ala Val Pro Ala Thr Leu Ala Phe Thr Tyr Lys Pro Pro Gly 
225                 230                 235                 240 


Leu Leu Arg Gly Gly Asp Ala Ser Leu Gly Leu Arg Leu Val Glu Leu 
                245                 250                 255     


Ser Gly Lys Glu Gly Gln Glu Thr Leu Val Lys Glu Glu Val Glu Ala 
            260                 265                 270         


Phe Leu Arg Ser Glu Ala Leu Gly Asp Ile Leu Gln Val Ala Val Lys 
        275                 280                 285             


Leu Ser Gly Trp Arg Trp Arg Gly Arg Gln Ala Trp Arg Leu His Pro 
    290                 295                 300                 


Arg Ala Glu Leu Gly Ala Val Val Asp Thr Val Leu Ala Leu Leu Glu 
305                 310                 315                 320 


Lys Leu Glu Glu Glu Glu Ser Val Leu Val Glu Ala Val Tyr Pro Pro 
                325                 330                 335     


Ala Gln Leu Pro Cys Ser Asp Gly Pro Ser Pro Gly Pro Gly Leu Ala 
            340                 345                 350         


Val Arg Ile Cys Ala Val Val Cys Arg Thr Gln Gly Asp Arg Pro Leu 
        355                 360                 365             


Leu Ser Lys Val Val Cys Gly Val Gly Arg Gly Asp Arg Pro Leu Arg 
    370                 375                 380                 


His His Asn Ser Leu Pro Arg Thr Leu Glu Val Ala Leu Ala Gln Cys 
385                 390                 395                 400 


Gly Leu Gly Glu Glu Ala Gln Val Ala Ala Val Arg Gln Arg Val Lys 
                405                 410                 415     


Ala Ala Ala Glu Ala Ala Leu Ala Ala Val Leu Ala Leu Glu Ala Gly 
            420                 425                 430         


Leu Ser Ala Glu Gln Arg Gly Gly Arg Arg Ala His Thr Asp Phe Leu 
        435                 440                 445             


Gly Val Asp Phe Ala Leu Thr Ala Ala Gly Gly Val Leu Thr Pro Val 
    450                 455                 460                 


Ala Leu Glu Leu Asn Gly Gly Leu Cys Leu Glu Ala Cys Gly Ala Leu 
465                 470                 475                 480 


Glu Gly Leu Trp Ala Ala Pro Arg Leu Gly Pro Ala Ala Asp Glu Ala 
                485                 490                 495     


Val Ala Ala Pro Leu Val Glu Thr Met Leu Arg Arg Ser Ala Arg Cys 
            500                 505                 510         


Leu Met Glu Gly Lys Gln Leu Leu Val Val Gly Ala Gly Gly Val Ser 
        515                 520                 525             


Lys Lys Phe Val Trp Glu Ala Ala Arg Asp Tyr Gly Leu Gln Leu His 
    530                 535                 540                 


Leu Val Glu Ser Asp Pro Asn His Phe Ala Ser Gln Leu Val Gln Thr 
545                 550                 555                 560 


Phe Ile His Phe Asp Met Thr Glu His Arg Arg Asp Glu Glu Asn Ala 
                565                 570                 575     


Arg Leu Leu Ala Glu Leu Val Arg Ala Arg Gly Leu Lys Leu Asp Gly 
            580                 585                 590         


Cys Phe Ser Tyr Trp Asp Asp Cys Leu Val Leu Thr Ala Leu Leu Cys 
        595                 600                 605             


Gln Glu Leu Gly Leu Pro Cys Ser Ser Pro Ala Ala Met Arg Leu Ala 
    610                 615                 620                 


Lys Gln Lys Ser Leu Thr Gln Leu His Leu Leu His His His Gly Pro 
625                 630                 635                 640 


Pro Trp Pro Ala Pro Ser Leu His Ala Val Pro Cys Cys Pro Leu Glu 
                645                 650                 655     


Ser Glu Ala Asp Val Glu Arg Ala Val His Gln Val Pro Leu Pro Gly 
            660                 665                 670         


Val Met Lys Leu Glu Phe Gly Ala Gly Ala Val Gly Val Arg Leu Val 
        675                 680                 685             


Glu Asp Ala Pro Gln Cys His Glu His Phe Ser Arg Ile Thr Arg Asp 
    690                 695                 700                 


Leu Gln Gly Glu Ala Asp His Pro Gly Ile Gly Leu Gly Trp Gly Asn 
705                 710                 715                 720 


Ala Met Leu Leu Met Glu Phe Val Glu Gly Thr Glu His Asp Val Asp 
                725                 730                 735     


Leu Val Leu Phe Gly Gly Arg Leu Leu Ala Ala Phe Val Ser Asp Asn 
            740                 745                 750         


Gly Pro Thr Arg Leu Pro Gly Phe Thr Glu Thr Ala Ala Cys Met Pro 
        755                 760                 765             


Thr Gly Leu Ala Pro Glu Gln Glu Ala Gln Met Val Gln Ala Ala Phe 
    770                 775                 780                 


Arg Cys Cys Leu Gly Cys Gly Leu Leu Asp Gly Val Phe Asn Val Glu 
785                 790                 795                 800 


Leu Lys Leu Thr Gly Ala Gly Pro Arg Leu Ile Glu Ile Asn Pro Arg 
                805                 810                 815     


Met Gly Gly Phe Tyr Leu Arg Asp Trp Ile Leu Glu Leu Tyr Gly Val 
            820                 825                 830         


Asp Leu Leu Leu Ala Ala Val Met Val Ala Cys Gly Leu Arg Pro Ala 
        835                 840                 845             


Leu Pro Thr Arg Pro Arg Ala Arg Gly His Leu Val Gly Val Met Cys 
    850                 855                 860                 


Leu Val Ser Gln His Leu Gln Ala Leu Ser Ser Thr Ala Ser Arg Glu 
865                 870                 875                 880 


Thr Leu Gln Ala Leu His Asp Arg Gly Leu Leu Arg Leu Asn Leu Leu 
                885                 890                 895     


Glu Glu Ala Leu Val Pro Gly Glu Tyr Glu Glu Pro Tyr Cys Ser Val 
            900                 905                 910         


Ala Cys Ala Gly Pro Ser Pro Thr Glu Ala Arg Leu Arg Leu Leu Gly 
        915                 920                 925             


Leu Cys Gln Gly Leu Gly Ile Asp Gly Pro Ser Tyr Pro Val Ala His 
    930                 935                 940                 


Phe Leu Ser His Phe Lys 
945                 950 


<210>  2061
<211>  924
<212>  PRT
<213>  Homo Sapiens

<400>  2061

Met Leu Ser Leu Asp Pro Ser Gly Pro Glu Trp Asp Cys Pro Leu Gly 
1               5                   10                  15      


Ser Lys Asp Leu Glu Glu Glu Gly Pro Trp Gly Gly Gly Ser Gly Leu 
            20                  25                  30          


Pro Pro Thr Gly Cys Phe Pro Gly Ser Trp Arg Gln Asp Val Gly Leu 
        35                  40                  45              


Asp Cys Lys Gly Ser Pro Glu Gly Ala Glu Ala Arg Ala Trp Thr Val 
    50                  55                  60                  


Tyr Tyr Tyr Ser Leu Leu Gln Ser Cys Leu Gln Gln Ala Gly Leu Pro 
65                  70                  75                  80  


Glu Thr Gln Asp Arg Gly Gln Val Pro Arg Thr Gly Cys Pro Gly Ala 
                85                  90                  95      


Glu Val Thr Leu Cys Val Leu Gly Ser Pro Ser Thr Phe Leu Pro Val 
            100                 105                 110         


Leu Leu Glu Gly Gly Val Gln Ser Pro Gly Asn Met Leu Leu Cys Leu 
        115                 120                 125             


Ser Pro Ala Trp Leu Met Lys Val Pro Ala Pro Gly Gln Pro Gly Glu 
    130                 135                 140                 


Ala Ala Leu Leu Val Ser Lys Ala Val Ser Phe His Pro Gly Gly Leu 
145                 150                 155                 160 


Thr Phe Leu Asp Asp Phe Val Pro Pro Arg Arg Ala Thr Tyr Phe Leu 
                165                 170                 175     


Ala Gly Leu Gly Leu Gly Pro Gly Arg Gly Arg Glu Ala Ala Glu Leu 
            180                 185                 190         


Ala Arg Asp Leu Thr Cys Pro Thr Gly Ala Ser Ala Glu Leu Ala Arg 
        195                 200                 205             


Leu Leu Glu Asp Arg Leu Leu Thr Arg Gln Leu Leu Ala Gln Gln Gly 
    210                 215                 220                 


Gly Val Ala Val Pro Ala Thr Leu Ala Phe Thr Tyr Lys Pro Pro Gly 
225                 230                 235                 240 


Leu Leu Arg Gly Gly Asp Ala Ser Leu Gly Leu Arg Leu Val Glu Leu 
                245                 250                 255     


Ser Gly Lys Glu Gly Gln Glu Thr Leu Val Lys Glu Glu Val Glu Ala 
            260                 265                 270         


Phe Leu Arg Ser Glu Ala Leu Gly Asp Ile Leu Gln Val Ala Val Lys 
        275                 280                 285             


Leu Ser Gly Trp Arg Trp Arg Gly Arg Gln Ala Trp Arg Leu His Pro 
    290                 295                 300                 


Arg Ala Glu Leu Gly Ala Val Val Asp Thr Val Leu Ala Leu Leu Glu 
305                 310                 315                 320 


Lys Leu Glu Glu Glu Glu Ser Val Leu Val Glu Ala Val Tyr Pro Pro 
                325                 330                 335     


Ala Gln Leu Pro Cys Ser Asp Gly Pro Ser Pro Gly Pro Gly Leu Ala 
            340                 345                 350         


Val Arg Ile Cys Ala Val Val Cys Arg Thr Gln Gly Asp Arg Pro Leu 
        355                 360                 365             


Leu Ser Lys Val Val Cys Gly Val Gly Arg Gly Asp Arg Pro Leu Arg 
    370                 375                 380                 


His His Asn Ser Leu Pro Arg Thr Leu Glu Ala Ala Leu Ala Ala Val 
385                 390                 395                 400 


Leu Ala Leu Glu Ala Gly Leu Ser Ala Glu Gln Arg Gly Gly Arg Arg 
                405                 410                 415     


Ala His Thr Asp Phe Leu Gly Val Asp Phe Ala Leu Thr Ala Ala Gly 
            420                 425                 430         


Gly Val Leu Thr Pro Val Ala Leu Glu Leu Asn Gly Gly Leu Cys Leu 
        435                 440                 445             


Glu Ala Cys Gly Ala Leu Glu Gly Leu Trp Ala Ala Pro Arg Leu Gly 
    450                 455                 460                 


Pro Ala Ala Asp Glu Ala Val Ala Ala Pro Leu Val Glu Thr Met Leu 
465                 470                 475                 480 


Arg Arg Ser Ala Arg Cys Leu Met Glu Gly Lys Gln Leu Leu Val Val 
                485                 490                 495     


Gly Ala Gly Gly Val Ser Lys Lys Phe Val Trp Glu Ala Ala Arg Asp 
            500                 505                 510         


Tyr Gly Leu Gln Leu His Leu Val Glu Ser Asp Pro Asn His Phe Ala 
        515                 520                 525             


Ser Gln Leu Val Gln Thr Phe Ile His Phe Asp Met Thr Glu His Arg 
    530                 535                 540                 


Arg Asp Glu Glu Asn Ala Arg Leu Leu Ala Glu Leu Val Arg Ala Arg 
545                 550                 555                 560 


Gly Leu Lys Leu Asp Gly Cys Phe Ser Tyr Trp Asp Asp Cys Leu Val 
                565                 570                 575     


Leu Thr Ala Leu Leu Cys Gln Glu Leu Gly Leu Pro Cys Ser Ser Pro 
            580                 585                 590         


Ala Ala Met Arg Leu Ala Lys Gln Lys Ser Leu Thr Gln Leu His Leu 
        595                 600                 605             


Leu His His His Gly Pro Pro Trp Pro Ala Pro Ser Leu His Ala Val 
    610                 615                 620                 


Pro Cys Cys Pro Leu Glu Ser Glu Ala Asp Val Glu Arg Ala Val His 
625                 630                 635                 640 


Gln Val Pro Leu Pro Gly Val Met Lys Leu Glu Phe Gly Ala Gly Ala 
                645                 650                 655     


Val Gly Val Arg Leu Val Glu Asp Ala Pro Gln Cys His Glu His Phe 
            660                 665                 670         


Ser Arg Ile Thr Arg Asp Leu Gln Gly Glu Ala Asp His Pro Gly Ile 
        675                 680                 685             


Gly Leu Gly Trp Gly Asn Ala Met Leu Leu Met Glu Phe Val Glu Gly 
    690                 695                 700                 


Thr Glu His Asp Val Asp Leu Val Leu Phe Gly Gly Arg Leu Leu Ala 
705                 710                 715                 720 


Ala Phe Val Ser Asp Asn Gly Pro Thr Arg Leu Pro Gly Phe Thr Glu 
                725                 730                 735     


Thr Ala Ala Cys Met Pro Thr Gly Leu Ala Pro Glu Gln Glu Ala Gln 
            740                 745                 750         


Met Val Gln Ala Ala Phe Arg Cys Cys Leu Gly Cys Gly Leu Leu Asp 
        755                 760                 765             


Gly Val Phe Asn Val Glu Leu Lys Leu Thr Gly Ala Gly Pro Arg Leu 
    770                 775                 780                 


Ile Glu Ile Asn Pro Arg Met Gly Gly Phe Tyr Leu Arg Asp Trp Ile 
785                 790                 795                 800 


Leu Glu Leu Tyr Gly Val Asp Leu Leu Leu Ala Ala Val Met Val Ala 
                805                 810                 815     


Cys Gly Leu Arg Pro Ala Leu Pro Thr Arg Pro Arg Ala Arg Gly His 
            820                 825                 830         


Leu Val Gly Val Met Cys Leu Val Ser Gln His Leu Gln Ala Leu Ser 
        835                 840                 845             


Ser Thr Ala Ser Arg Glu Thr Leu Gln Ala Leu His Asp Arg Gly Leu 
    850                 855                 860                 


Leu Arg Leu Asn Leu Leu Glu Glu Ala Leu Val Pro Gly Glu Tyr Glu 
865                 870                 875                 880 


Glu Pro Tyr Cys Ser Val Ala Cys Ala Gly Pro Ser Pro Thr Glu Ala 
                885                 890                 895     


Arg Leu Arg Leu Leu Gly Leu Cys Gln Gly Leu Gly Ile Asp Gly Pro 
            900                 905                 910         


Ser Tyr Pro Val Ala His Phe Leu Ser His Phe Lys 
        915                 920                 


<210>  2062
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  2062

Met Glu Ser Ser Arg Val Arg Leu Leu Pro Leu Leu Gly Ala Ala Leu 
1               5                   10                  15      


Leu Leu Met Leu Pro Leu Leu Gly Thr Arg Ala Gln Glu Asp Ala Glu 
            20                  25                  30          


Leu Gln Pro Arg Ala Leu Asp Ile Tyr Ser Ala Val Asp Asp Ala Ser 
        35                  40                  45              


His Glu Lys Glu Leu Ile Glu Ala Leu Gln Glu Val Leu Lys Lys Leu 
    50                  55                  60                  


Lys Ser Lys Arg Val Pro Ile Tyr Glu Lys Lys Tyr Gly Gln Val Pro 
65                  70                  75                  80  


Met Cys Asp Ala Gly Glu Gln Cys Ala Val Arg Lys Gly Ala Arg Ile 
                85                  90                  95      


Gly Lys Leu Cys Asp Cys Pro Arg Gly Thr Ser Cys Asn Ser Phe Leu 
            100                 105                 110         


Leu Lys Cys Leu 
        115     


<210>  2063
<211>  117
<212>  PRT
<213>  Homo Sapiens

<400>  2063

Met Asp Gly Ile His Ile Val Ala Phe Ala Glu Glu Ala Asp Pro Asp 
1               5                   10                  15      


Gly Phe Glu Phe Leu Glu Thr Leu Lys Ala Val Ala Gln Asp Asn Thr 
            20                  25                  30          


Glu Asn Pro Asp Leu Ser Ile Ile Trp Ile Asp Pro Asp Asp Phe Pro 
        35                  40                  45              


Leu Leu Val Pro Tyr Trp Glu Lys Thr Phe Asp Ile Asp Leu Ser Ala 
    50                  55                  60                  


Pro Gln Ile Gly Val Val Asn Val Thr Asp Ala Asp Ser Val Trp Met 
65                  70                  75                  80  


Glu Met Asp Asp Glu Glu Asp Leu Pro Ser Ala Glu Glu Leu Glu Asp 
                85                  90                  95      


Trp Leu Glu Asp Val Leu Glu Gly Glu Ile Asn Thr Glu Asp Asp Asp 
            100                 105                 110         


Asp Asp Asp Asp Asp 
        115         


<210>  2064
<211>  396
<212>  PRT
<213>  Homo Sapiens

<400>  2064

Met Ser Ala Thr Asp Arg Met Gly Pro Arg Ala Val Pro Gly Leu Arg 
1               5                   10                  15      


Leu Ala Leu Leu Leu Leu Leu Val Leu Gly Thr Pro Lys Ser Gly Val 
            20                  25                  30          


Gln Gly Gln Glu Gly Leu Asp Phe Pro Glu Tyr Asp Gly Val Asp Arg 
        35                  40                  45              


Val Ile Asn Val Asn Ala Lys Asn Tyr Lys Asn Val Phe Lys Lys Tyr 
    50                  55                  60                  


Glu Val Leu Ala Leu Leu Tyr His Glu Pro Pro Glu Asp Asp Lys Ala 
65                  70                  75                  80  


Ser Gln Arg Gln Phe Glu Met Glu Glu Leu Ile Leu Glu Leu Ala Ala 
                85                  90                  95      


Gln Val Leu Glu Asp Lys Gly Val Gly Phe Gly Leu Val Asp Ser Glu 
            100                 105                 110         


Lys Asp Ala Ala Val Ala Lys Lys Leu Gly Leu Thr Glu Val Asp Ser 
        115                 120                 125             


Met Tyr Val Phe Lys Gly Asp Glu Val Ile Glu Tyr Asp Gly Glu Phe 
    130                 135                 140                 


Ser Ala Asp Thr Ile Val Glu Phe Leu Leu Asp Val Leu Glu Asp Pro 
145                 150                 155                 160 


Val Glu Leu Ile Glu Gly Glu Arg Glu Leu Gln Ala Phe Glu Asn Ile 
                165                 170                 175     


Glu Asp Glu Ile Lys Leu Ile Gly Tyr Phe Lys Ser Lys Asp Ser Glu 
            180                 185                 190         


His Tyr Lys Ala Phe Glu Asp Ala Ala Glu Glu Phe His Pro Tyr Ile 
        195                 200                 205             


Pro Phe Phe Ala Thr Phe Asp Ser Lys Val Ala Lys Lys Leu Thr Leu 
    210                 215                 220                 


Lys Leu Asn Glu Ile Asp Phe Tyr Glu Ala Phe Met Glu Glu Pro Val 
225                 230                 235                 240 


Thr Ile Pro Asp Lys Pro Asn Ser Glu Glu Glu Ile Val Asn Phe Val 
                245                 250                 255     


Glu Glu His Arg Arg Ser Thr Leu Arg Lys Leu Lys Pro Glu Ser Met 
            260                 265                 270         


Tyr Glu Thr Trp Glu Asp Asp Met Asp Gly Ile His Ile Val Ala Phe 
        275                 280                 285             


Ala Glu Glu Ala Asp Pro Asp Gly Phe Glu Phe Leu Glu Thr Leu Lys 
    290                 295                 300                 


Ala Val Ala Gln Asp Asn Thr Glu Asn Pro Asp Leu Ser Ile Ile Trp 
305                 310                 315                 320 


Ile Asp Pro Asp Asp Phe Pro Leu Leu Val Pro Tyr Trp Glu Lys Thr 
                325                 330                 335     


Phe Asp Ile Asp Leu Ser Ala Pro Gln Ile Gly Val Val Asn Val Thr 
            340                 345                 350         


Asp Ala Asp Ser Val Trp Met Glu Met Asp Asp Glu Glu Asp Leu Pro 
        355                 360                 365             


Ser Ala Glu Glu Leu Glu Asp Trp Leu Glu Asp Val Leu Glu Gly Glu 
    370                 375                 380                 


Ile Asn Thr Glu Asp Asp Asp Asp Asp Asp Asp Asp 
385                 390                 395     


<210>  2065
<211>  399
<212>  PRT
<213>  Homo Sapiens

<400>  2065

Met Lys Arg Thr His Leu Phe Ile Val Gly Ile Tyr Phe Leu Ser Ser 
1               5                   10                  15      


Cys Arg Ala Glu Glu Gly Leu Asn Phe Pro Thr Tyr Asp Gly Lys Asp 
            20                  25                  30          


Arg Val Val Ser Leu Ser Glu Lys Asn Phe Lys Gln Val Leu Lys Lys 
        35                  40                  45              


Tyr Asp Leu Leu Cys Leu Tyr Tyr His Glu Pro Val Ser Ser Asp Lys 
    50                  55                  60                  


Val Thr Gln Lys Gln Phe Gln Leu Lys Glu Ile Val Leu Glu Leu Val 
65                  70                  75                  80  


Ala Gln Val Leu Glu His Lys Ala Ile Gly Phe Val Met Val Asp Ala 
                85                  90                  95      


Lys Lys Glu Ala Lys Leu Ala Lys Lys Leu Gly Phe Asp Glu Glu Gly 
            100                 105                 110         


Ser Leu Tyr Ile Leu Lys Gly Asp Arg Thr Ile Glu Phe Asp Gly Glu 
        115                 120                 125             


Phe Ala Ala Asp Val Leu Val Glu Phe Leu Leu Asp Leu Ile Glu Asp 
    130                 135                 140                 


Pro Val Glu Ile Ile Ser Ser Lys Leu Glu Val Gln Ala Phe Glu Arg 
145                 150                 155                 160 


Ile Glu Asp Tyr Ile Lys Leu Ile Gly Phe Phe Lys Ser Glu Asp Ser 
                165                 170                 175     


Glu Tyr Tyr Lys Ala Phe Glu Glu Ala Ala Glu His Phe Gln Pro Tyr 
            180                 185                 190         


Ile Lys Phe Phe Ala Thr Phe Asp Lys Gly Val Ala Lys Lys Leu Ser 
        195                 200                 205             


Leu Lys Met Asn Glu Val Asp Phe Tyr Glu Pro Phe Met Asp Glu Pro 
    210                 215                 220                 


Ile Ala Ile Pro Asn Lys Pro Tyr Thr Glu Glu Glu Leu Val Glu Phe 
225                 230                 235                 240 


Val Lys Glu His Gln Arg Pro Thr Leu Arg Arg Leu Arg Pro Glu Glu 
                245                 250                 255     


Met Phe Glu Thr Trp Glu Asp Asp Leu Asn Gly Ile His Ile Val Ala 
            260                 265                 270         


Phe Ala Glu Lys Ser Asp Pro Asp Gly Tyr Glu Phe Leu Glu Ile Leu 
        275                 280                 285             


Lys Gln Val Ala Arg Asp Asn Thr Asp Asn Pro Asp Leu Ser Ile Leu 
    290                 295                 300                 


Trp Ile Asp Pro Asp Asp Phe Pro Leu Leu Val Ala Tyr Trp Glu Lys 
305                 310                 315                 320 


Thr Phe Lys Ile Asp Leu Phe Arg Pro Gln Ile Gly Val Val Asn Val 
                325                 330                 335     


Thr Asp Ala Asp Ser Val Trp Met Glu Ile Pro Asp Asp Asp Asp Leu 
            340                 345                 350         


Pro Thr Ala Glu Glu Leu Glu Asp Trp Ile Glu Asp Val Leu Ser Gly 
        355                 360                 365             


Lys Ile Asn Thr Glu Asp Asp Asp Glu Asp Asp Asp Asp Asp Asp Asn 
    370                 375                 380                 


Ser Asp Glu Glu Asp Asn Asp Asp Ser Asp Asp Asp Asp Asp Glu 
385                 390                 395                 


<210>  2066
<211>  1119
<212>  PRT
<213>  Homo Sapiens

<400>  2066

Met Cys Gly Pro Ala Met Phe Pro Ala Gly Pro Pro Trp Pro Arg Val 
1               5                   10                  15      


Arg Val Val Gln Val Leu Trp Ala Leu Leu Ala Val Leu Leu Ala Ser 
            20                  25                  30          


Trp Arg Leu Trp Ala Ile Lys Asp Phe Gln Glu Cys Thr Trp Gln Val 
        35                  40                  45              


Val Leu Asn Glu Phe Lys Arg Val Gly Glu Ser Gly Val Ser Asp Ser 
    50                  55                  60                  


Phe Phe Glu Gln Glu Pro Val Asp Thr Val Ser Ser Leu Phe His Met 
65                  70                  75                  80  


Leu Val Asp Ser Pro Ile Asp Pro Ser Glu Lys Tyr Leu Gly Phe Pro 
                85                  90                  95      


Tyr Tyr Leu Lys Ile Asn Tyr Ser Cys Glu Glu Lys Pro Ser Glu Asp 
            100                 105                 110         


Leu Val Arg Met Gly His Leu Thr Gly Leu Lys Pro Leu Val Leu Val 
        115                 120                 125             


Thr Phe Gln Ser Pro Val Asn Phe Tyr Arg Trp Lys Ile Glu Gln Leu 
    130                 135                 140                 


Gln Ile Gln Met Glu Ala Ala Pro Phe Arg Ser Lys Glu Pro Cys Met 
145                 150                 155                 160 


Ala Glu Glu Val Cys Ser Met Ser Trp Tyr Thr Pro Met Pro Ile Lys 
                165                 170                 175     


Lys Gly Ser Val Val Met Arg Val Asp Ile Ser Ser Asn Gly Leu Gly 
            180                 185                 190         


Thr Phe Ile Pro Asp Lys Arg Phe Gln Met Asn Ile Asn Gly Phe Leu 
        195                 200                 205             


Lys Arg Asp Arg Asp Asn Asn Ile Gln Phe Thr Val Gly Glu Glu Leu 
    210                 215                 220                 


Phe Asn Leu Met Pro Gln Tyr Phe Val Gly Val Ser Ser Arg Pro Leu 
225                 230                 235                 240 


Trp His Thr Val Asp Gln Ser Pro Val Leu Ile Leu Gly Gly Ile Pro 
                245                 250                 255     


Asn Glu Lys Tyr Val Leu Met Thr Asp Thr Ser Phe Lys Asp Phe Ser 
            260                 265                 270         


Leu Val Glu Leu Ser Ile Asp Ser Cys Trp Val Gly Ser Phe Tyr Cys 
        275                 280                 285             


Pro His Ser Gly Phe Thr Ala Thr Ile Tyr Asp Thr Ile Ala Thr Glu 
    290                 295                 300                 


Ser Thr Leu Phe Ile Arg Gln Asn Gln Leu Val Tyr Tyr Phe Thr Gly 
305                 310                 315                 320 


Thr Tyr Thr Thr Leu Tyr Glu Arg Asn Arg Gly Ser Gly Ser Trp Ile 
                325                 330                 335     


Arg Val Leu Ala Ser Glu Cys Ile Lys Lys Leu Cys Pro Val Tyr Phe 
            340                 345                 350         


His Ser Asn Gly Ser Glu Tyr Ile Met Ala Leu Thr Thr Gly Lys His 
        355                 360                 365             


Glu Gly Tyr Val His Phe Gly Thr Ile Arg Asp Gly Gln Val Ser Phe 
    370                 375                 380                 


Glu Met Leu Pro Arg Gln Trp Ser Val Cys Glu Gln Ile Gly Ala Ser 
385                 390                 395                 400 


Asp Asp Leu Glu Leu Leu Tyr His Ile Pro Glu Phe Ile Pro Glu Ala 
                405                 410                 415     


Arg Gly Leu Glu Phe Leu Met Ile Leu Gly Thr Glu Ser Tyr Thr Ser 
            420                 425                 430         


Thr Ala Met Ala Pro Lys Gly Ile Phe Cys Asn Pro Tyr Asn Asn Leu 
        435                 440                 445             


Ile Phe Ile Trp Gly Asn Phe Leu Leu Gln Ser Ser Asn Lys Glu Asn 
    450                 455                 460                 


Phe Ile Tyr Leu Ala Asp Phe Pro Lys Glu Leu Ser Ile Lys Tyr Met 
465                 470                 475                 480 


Ala Arg Ser Phe Arg Gly Ala Val Ala Ile Val Thr Glu Thr Glu Glu 
                485                 490                 495     


Ile Trp Tyr Leu Leu Glu Gly Ser Tyr Arg Val Tyr Gln Leu Phe Pro 
            500                 505                 510         


Ser Lys Gly Trp Gln Val His Ile Ser Leu Lys Leu Met Gln Gln Ser 
        515                 520                 525             


Ser Leu Tyr Ala Ser Asn Glu Thr Met Leu Thr Leu Phe Tyr Glu Asp 
    530                 535                 540                 


Ser Lys Leu Tyr Gln Leu Val Tyr Leu Met Asn Asn Gln Lys Gly Gln 
545                 550                 555                 560 


Leu Val Lys Arg Leu Val Pro Val Glu Gln Leu Leu Met Tyr Gln Gln 
                565                 570                 575     


His Thr Ser His Tyr Asp Leu Glu Arg Lys Gly Gly Tyr Leu Met Leu 
            580                 585                 590         


Ser Phe Ile Asp Phe Cys Pro Phe Ser Val Met Arg Leu Arg Ser Leu 
        595                 600                 605             


Pro Ser Pro Gln Arg Tyr Thr Arg Gln Glu Arg Tyr Arg Ala Arg Pro 
    610                 615                 620                 


Pro Arg Val Leu Glu Arg Ser Gly Phe His Asn Glu Asn Ser Leu Ala 
625                 630                 635                 640 


Ile Tyr Gln Gly Leu Val Tyr Tyr Leu Leu Trp Leu His Ser Val Tyr 
                645                 650                 655     


Asp Lys Pro Tyr Ala Asp Pro Val His Asp Pro Thr Trp Arg Trp Trp 
            660                 665                 670         


Ala Asn Asn Lys Gln Asp Gln Asp Tyr Tyr Phe Phe Leu Ala Ser Asn 
        675                 680                 685             


Trp Arg Ser Ala Gly Gly Val Ser Ile Glu Met Asp Ser Tyr Glu Lys 
    690                 695                 700                 


Ile Tyr Asn Leu Glu Ser Ala Tyr Glu Leu Pro Glu Arg Ile Phe Leu 
705                 710                 715                 720 


Asp Lys Gly Thr Glu Tyr Ser Phe Ala Ile Phe Leu Ser Ala Gln Gly 
                725                 730                 735     


His Ser Phe Arg Thr Gln Ser Glu Leu Gly Thr Ala Phe Gln Leu His 
            740                 745                 750         


Ser Gln Val Asp Val Gly Val Val Leu Ala Asp Pro Gly Cys Ile Glu 
        755                 760                 765             


Ala Ser Val Lys Gln Glu Val Leu Ile Asn Arg Asn Ser Val Leu Phe 
    770                 775                 780                 


Ser Ile Thr Leu Lys Asp Lys Lys Leu Cys Tyr Asp Gln Gly Ile Ser 
785                 790                 795                 800 


Gly His His Leu Met Glu Thr Ser Met Thr Val Asn Val Val Gly Ser 
                805                 810                 815     


Ser Gly Leu Cys Phe Gln Glu Thr His Leu Gly Pro His Met Gln Gly 
            820                 825                 830         


Asn Leu Met Val Pro Val Phe Ile Gly Cys Pro Pro Gly Lys Arg Leu 
        835                 840                 845             


Ala Phe Asp Ile Thr Tyr Thr Leu Glu Tyr Ser Arg Leu Lys Asn Lys 
    850                 855                 860                 


His Tyr Phe Asp Cys Val Asn Val Asn Pro Glu Met Pro Cys Phe Leu 
865                 870                 875                 880 


Phe Arg Asp Ile Phe Tyr Pro Phe Phe Leu Ile Gln Asp Leu Val Thr 
                885                 890                 895     


Gly Asp Ser Gly Ser Phe Gln Gly Ser Tyr Val Leu Leu Val Val Gly 
            900                 905                 910         


Gly Gly Pro Thr Leu Asp Ser Leu Lys Asp Tyr Ser Glu Asp Glu Ile 
        915                 920                 925             


Tyr Arg Phe Asn Ser Pro Leu Asp Lys Thr Asn Ser Leu Ile Trp Thr 
    930                 935                 940                 


Thr Arg Thr Thr Arg Thr Thr Lys Asp Ser Ala Phe His Ile Met Ser 
945                 950                 955                 960 


His Glu Ser Pro Gly Ile Glu Trp Leu Cys Leu Glu Asn Ala Pro Cys 
                965                 970                 975     


Tyr Asp Asn Val Pro Gln Gly Ile Phe Ala Pro Glu Phe Phe Phe Lys 
            980                 985                 990         


Val Leu Val Ser Asn Arg Gly Val  Asp Thr Ser Thr Tyr  Cys Asn Tyr 
        995                 1000                 1005             


Gln Leu  Thr Phe Leu Leu His  Ile His Gly Leu Pro  Leu Ser Pro 
    1010                 1015                 1020             


Lys Arg  Ala Leu Phe Ile Ile  Met Val Ser Ala Ser  Val Phe Val 
    1025                 1030                 1035             


Gly Leu  Val Ile Phe Tyr Ile  Ala Phe Cys Leu Leu  Trp Pro Leu 
    1040                 1045                 1050             


Val Val  Lys Gly Cys Thr Met  Ile Arg Trp Lys Ile  Asn Asn Leu 
    1055                 1060                 1065             


Ile Ala  Ser Glu Ser Tyr Tyr  Thr Tyr Ala Ser Ile  Ser Gly Ile 
    1070                 1075                 1080             


Ser Ser  Met Pro Ser Leu Arg  His Ser Arg Met Gly  Ser Met Phe 
    1085                 1090                 1095             


Ser Ser  Arg Met Thr Glu Asp  Arg Ala Glu Pro Lys  Glu Ala Val 
    1100                 1105                 1110             


Glu Arg  Gln Leu Met Thr 
    1115                 


<210>  2067
<211>  661
<212>  PRT
<213>  Homo Sapiens

<400>  2067

Met Cys Gly Pro Ala Met Phe Pro Ala Gly Pro Pro Trp Pro Arg Val 
1               5                   10                  15      


Arg Val Val Gln Val Leu Trp Ala Leu Leu Ala Val Leu Leu Ala Ser 
            20                  25                  30          


Trp Arg Leu Trp Ala Ile Lys Asp Phe Gln Glu Cys Thr Trp Gln Val 
        35                  40                  45              


Val Leu Asn Glu Phe Lys Arg Val Gly Glu Ser Gly Val Ser Asp Ser 
    50                  55                  60                  


Phe Phe Glu Gln Glu Pro Val Asp Thr Val Ser Ser Leu Phe His Met 
65                  70                  75                  80  


Leu Val Asp Ser Pro Ile Asp Pro Ser Glu Lys Tyr Leu Gly Phe Pro 
                85                  90                  95      


Tyr Tyr Leu Lys Ile Asn Tyr Ser Cys Glu Glu Lys Pro Ser Glu Asp 
            100                 105                 110         


Leu Val Arg Met Gly His Leu Thr Gly Leu Lys Pro Leu Val Leu Val 
        115                 120                 125             


Thr Phe Gln Ser Pro Val Asn Phe Tyr Arg Trp Lys Ile Glu Gln Leu 
    130                 135                 140                 


Gln Ile Gln Met Glu Ala Ala Pro Phe Arg Ser Lys Glu Pro Cys Met 
145                 150                 155                 160 


Ala Glu Glu Val Cys Ser Met Ser Trp Tyr Thr Pro Met Pro Ile Lys 
                165                 170                 175     


Lys Gly Ser Val Val Met Arg Val Asp Ile Ser Ser Asn Gly Leu Gly 
            180                 185                 190         


Thr Phe Ile Pro Asp Lys Arg Phe Gln Met Asn Ile Asn Gly Phe Leu 
        195                 200                 205             


Lys Arg Asp Arg Asp Asn Asn Ile Gln Phe Thr Val Gly Glu Glu Leu 
    210                 215                 220                 


Phe Asn Leu Met Pro Gln Tyr Phe Val Gly Val Ser Ser Arg Pro Leu 
225                 230                 235                 240 


Trp His Thr Val Asp Gln Ser Pro Val Leu Ile Leu Gly Gly Ile Pro 
                245                 250                 255     


Asn Glu Lys Tyr Val Leu Met Thr Asp Thr Ser Phe Lys Asp Phe Ser 
            260                 265                 270         


Leu Val Glu Leu Ser Ile Asp Ser Cys Trp Val Gly Ser Phe Tyr Cys 
        275                 280                 285             


Pro His Ser Gly Phe Thr Ala Thr Ile Tyr Asp Thr Ile Ala Thr Glu 
    290                 295                 300                 


Ser Thr Leu Phe Ile Arg Gln Asn Gln Leu Val Tyr Tyr Phe Thr Gly 
305                 310                 315                 320 


Thr Tyr Thr Thr Leu Tyr Glu Arg Asn Arg Gly Ser Gly Ser Trp Ile 
                325                 330                 335     


Arg Val Leu Ala Ser Glu Cys Ile Lys Lys Leu Cys Pro Val Tyr Phe 
            340                 345                 350         


His Ser Asn Gly Ser Glu Tyr Ile Met Ala Leu Thr Thr Gly Lys His 
        355                 360                 365             


Glu Gly Tyr Val His Phe Gly Thr Ile Arg Asp Gly Gln Val Ser Phe 
    370                 375                 380                 


Glu Met Leu Pro Arg Gln Trp Ser Val Cys Glu Gln Ile Gly Val Thr 
385                 390                 395                 400 


Thr Cys Ser Ile Ile Trp Ser Glu Tyr Ile Ala Gly Glu Tyr Thr Leu 
                405                 410                 415     


Leu Leu Leu Val Glu Ser Gly Tyr Gly Asn Ala Ser Lys Arg Phe Gln 
            420                 425                 430         


Val Val Ser Tyr Asn Thr Ala Ser Asp Asp Leu Glu Leu Leu Tyr His 
        435                 440                 445             


Ile Pro Glu Phe Ile Pro Glu Ala Arg Gly Leu Glu Phe Leu Met Ile 
    450                 455                 460                 


Leu Gly Thr Glu Ser Tyr Thr Ser Thr Ala Met Ala Pro Lys Gly Ile 
465                 470                 475                 480 


Phe Cys Asn Pro Tyr Asn Asn Leu Ile Phe Ile Trp Gly Asn Phe Leu 
                485                 490                 495     


Leu Gln Ser Ser Asn Lys Glu Asn Phe Ile Tyr Leu Ala Asp Phe Pro 
            500                 505                 510         


Lys Glu Leu Ser Ile Lys Tyr Met Ala Arg Ser Phe Arg Gly Ala Val 
        515                 520                 525             


Ala Ile Val Thr Glu Thr Glu Glu Ile Trp Tyr Leu Leu Glu Gly Ser 
    530                 535                 540                 


Tyr Arg Val Tyr Gln Leu Phe Pro Ser Lys Gly Trp Gln Val His Ile 
545                 550                 555                 560 


Ser Leu Lys Leu Met Gln Gln Ser Ser Leu Tyr Ala Ser Asn Glu Thr 
                565                 570                 575     


Met Leu Thr Leu Phe Tyr Glu Asp Ser Lys Leu Tyr Gln Leu Val Tyr 
            580                 585                 590         


Leu Met Asn Asn Gln Lys Gly Gln Leu Val Lys Arg Leu Val Pro Val 
        595                 600                 605             


Glu Gln Leu Leu Met Tyr Gln Gln His Thr Ser His Tyr Asp Leu Glu 
    610                 615                 620                 


Arg Lys Gly Gly Tyr Leu Met Leu Ser Phe Ile Asp Phe Cys Pro Phe 
625                 630                 635                 640 


Ser Val Met Arg Leu Arg Ser Leu Pro Ser Pro Gln Arg Tyr Thr Arg 
                645                 650                 655     


Gln Glu Arg Tyr Arg 
            660     


<210>  2068
<211>  1159
<212>  PRT
<213>  Homo Sapiens

<400>  2068

Met Cys Gly Pro Ala Met Phe Pro Ala Gly Pro Pro Trp Pro Arg Val 
1               5                   10                  15      


Arg Val Val Gln Val Leu Trp Ala Leu Leu Ala Val Leu Leu Ala Ser 
            20                  25                  30          


Trp Arg Leu Trp Ala Ile Lys Asp Phe Gln Glu Cys Thr Trp Gln Val 
        35                  40                  45              


Val Leu Asn Glu Phe Lys Arg Val Gly Glu Ser Gly Val Ser Asp Ser 
    50                  55                  60                  


Phe Phe Glu Gln Glu Pro Val Asp Thr Val Ser Ser Leu Phe His Met 
65                  70                  75                  80  


Leu Val Asp Ser Pro Ile Asp Pro Ser Glu Lys Tyr Leu Gly Phe Pro 
                85                  90                  95      


Tyr Tyr Leu Lys Ile Asn Tyr Ser Cys Glu Glu Lys Pro Ser Glu Asp 
            100                 105                 110         


Leu Val Arg Met Gly His Leu Thr Gly Leu Lys Pro Leu Val Leu Val 
        115                 120                 125             


Thr Phe Gln Ser Pro Val Asn Phe Tyr Arg Trp Lys Ile Glu Gln Leu 
    130                 135                 140                 


Gln Ile Gln Met Glu Ala Ala Pro Phe Arg Ser Lys Glu Pro Cys Met 
145                 150                 155                 160 


Ala Glu Glu Val Cys Ser Met Ser Trp Tyr Thr Pro Met Pro Ile Lys 
                165                 170                 175     


Lys Gly Ser Val Val Met Arg Val Asp Ile Ser Ser Asn Gly Leu Gly 
            180                 185                 190         


Thr Phe Ile Pro Asp Lys Arg Phe Gln Met Asn Ile Asn Gly Phe Leu 
        195                 200                 205             


Lys Arg Asp Arg Asp Asn Asn Ile Gln Phe Thr Val Gly Glu Glu Leu 
    210                 215                 220                 


Phe Asn Leu Met Pro Gln Tyr Phe Val Gly Val Ser Ser Arg Pro Leu 
225                 230                 235                 240 


Trp His Thr Val Asp Gln Ser Pro Val Leu Ile Leu Gly Gly Ile Pro 
                245                 250                 255     


Asn Glu Lys Tyr Val Leu Met Thr Asp Thr Ser Phe Lys Asp Phe Ser 
            260                 265                 270         


Leu Val Glu Leu Ser Ile Asp Ser Cys Trp Val Gly Ser Phe Tyr Cys 
        275                 280                 285             


Pro His Ser Gly Phe Thr Ala Thr Ile Tyr Asp Thr Ile Ala Thr Glu 
    290                 295                 300                 


Ser Thr Leu Phe Ile Arg Gln Asn Gln Leu Val Tyr Tyr Phe Thr Gly 
305                 310                 315                 320 


Thr Tyr Thr Thr Leu Tyr Glu Arg Asn Arg Gly Ser Gly Ser Trp Ile 
                325                 330                 335     


Arg Val Leu Ala Ser Glu Cys Ile Lys Lys Leu Cys Pro Val Tyr Phe 
            340                 345                 350         


His Ser Asn Gly Ser Glu Tyr Ile Met Ala Leu Thr Thr Gly Lys His 
        355                 360                 365             


Glu Gly Tyr Val His Phe Gly Thr Ile Arg Asp Gly Gln Val Ser Phe 
    370                 375                 380                 


Glu Met Leu Pro Arg Gln Trp Ser Val Cys Glu Gln Ile Gly Val Thr 
385                 390                 395                 400 


Thr Cys Ser Ile Ile Trp Ser Glu Tyr Ile Ala Gly Glu Tyr Thr Leu 
                405                 410                 415     


Leu Leu Leu Val Glu Ser Gly Tyr Gly Asn Ala Ser Lys Arg Phe Gln 
            420                 425                 430         


Val Val Ser Tyr Asn Thr Ala Ser Asp Asp Leu Glu Leu Leu Tyr His 
        435                 440                 445             


Ile Pro Glu Phe Ile Pro Glu Ala Arg Gly Leu Glu Phe Leu Met Ile 
    450                 455                 460                 


Leu Gly Thr Glu Ser Tyr Thr Ser Thr Ala Met Ala Pro Lys Gly Ile 
465                 470                 475                 480 


Phe Cys Asn Pro Tyr Asn Asn Leu Ile Phe Ile Trp Gly Asn Phe Leu 
                485                 490                 495     


Leu Gln Ser Ser Asn Lys Glu Asn Phe Ile Tyr Leu Ala Asp Phe Pro 
            500                 505                 510         


Lys Glu Leu Ser Ile Lys Tyr Met Ala Arg Ser Phe Arg Gly Ala Val 
        515                 520                 525             


Ala Ile Val Thr Glu Thr Glu Glu Ile Trp Tyr Leu Leu Glu Gly Ser 
    530                 535                 540                 


Tyr Arg Val Tyr Gln Leu Phe Pro Ser Lys Gly Trp Gln Val His Ile 
545                 550                 555                 560 


Ser Leu Lys Leu Met Gln Gln Ser Ser Leu Tyr Ala Ser Asn Glu Thr 
                565                 570                 575     


Met Leu Thr Leu Phe Tyr Glu Asp Ser Lys Leu Tyr Gln Leu Val Tyr 
            580                 585                 590         


Leu Met Asn Asn Gln Lys Gly Gln Leu Val Lys Arg Leu Val Pro Val 
        595                 600                 605             


Glu Gln Leu Leu Met Tyr Gln Gln His Thr Ser His Tyr Asp Leu Glu 
    610                 615                 620                 


Arg Lys Gly Gly Tyr Leu Met Leu Ser Phe Ile Asp Phe Cys Pro Phe 
625                 630                 635                 640 


Ser Val Met Arg Leu Arg Ser Leu Pro Ser Pro Gln Arg Tyr Thr Arg 
                645                 650                 655     


Gln Glu Arg Tyr Arg Ala Arg Pro Pro Arg Val Leu Glu Arg Ser Gly 
            660                 665                 670         


Phe His Asn Glu Asn Ser Leu Ala Ile Tyr Gln Gly Leu Val Tyr Tyr 
        675                 680                 685             


Leu Leu Trp Leu His Ser Val Tyr Asp Lys Pro Tyr Ala Asp Pro Val 
    690                 695                 700                 


His Asp Pro Thr Trp Arg Trp Trp Ala Asn Asn Lys Gln Asp Gln Asp 
705                 710                 715                 720 


Tyr Tyr Phe Phe Leu Ala Ser Asn Trp Arg Ser Ala Gly Gly Val Ser 
                725                 730                 735     


Ile Glu Met Asp Ser Tyr Glu Lys Ile Tyr Asn Leu Glu Ser Ala Tyr 
            740                 745                 750         


Glu Leu Pro Glu Arg Ile Phe Leu Asp Lys Gly Thr Glu Tyr Ser Phe 
        755                 760                 765             


Ala Ile Phe Leu Ser Ala Gln Gly His Ser Phe Arg Thr Gln Ser Glu 
    770                 775                 780                 


Leu Gly Thr Ala Phe Gln Leu His Ser Gln Val Asp Val Gly Val Val 
785                 790                 795                 800 


Leu Ala Asp Pro Gly Cys Ile Glu Ala Ser Val Lys Gln Glu Val Leu 
                805                 810                 815     


Ile Asn Arg Asn Ser Val Leu Phe Ser Ile Thr Leu Lys Asp Lys Lys 
            820                 825                 830         


Leu Cys Tyr Asp Gln Gly Ile Ser Gly His His Leu Met Glu Thr Ser 
        835                 840                 845             


Met Thr Val Asn Val Val Gly Ser Ser Gly Leu Cys Phe Gln Glu Thr 
    850                 855                 860                 


His Leu Gly Pro His Met Gln Gly Asn Leu Met Val Pro Val Phe Ile 
865                 870                 875                 880 


Gly Cys Pro Pro Gly Lys Arg Leu Ala Phe Asp Ile Thr Tyr Thr Leu 
                885                 890                 895     


Glu Tyr Ser Arg Leu Lys Asn Lys His Tyr Phe Asp Cys Val Asn Val 
            900                 905                 910         


Asn Pro Glu Met Pro Cys Phe Leu Phe Arg Asp Ile Phe Tyr Pro Phe 
        915                 920                 925             


Phe Leu Ile Gln Asp Leu Val Thr Gly Asp Ser Gly Ser Phe Gln Gly 
    930                 935                 940                 


Ser Tyr Val Leu Leu Val Val Gly Gly Gly Pro Thr Leu Asp Ser Leu 
945                 950                 955                 960 


Lys Asp Tyr Ser Glu Asp Glu Ile Tyr Arg Phe Asn Ser Pro Leu Asp 
                965                 970                 975     


Lys Thr Asn Ser Leu Ile Trp Thr Thr Arg Thr Thr Arg Thr Thr Lys 
            980                 985                 990         


Asp Ser Ala Phe His Ile Met Ser  His Glu Ser Pro Gly  Ile Glu Trp 
        995                 1000                 1005             


Leu Cys  Leu Glu Asn Ala Pro  Cys Tyr Asp Asn Val  Pro Gln Gly 
    1010                 1015                 1020             


Ile Phe  Ala Pro Glu Phe Phe  Phe Lys Val Leu Val  Ser Asn Arg 
    1025                 1030                 1035             


Gly Val  Asp Thr Ser Thr Tyr  Cys Asn Tyr Gln Leu  Thr Phe Leu 
    1040                 1045                 1050             


Leu His  Ile His Gly Leu Pro  Leu Ser Pro Lys Arg  Ala Leu Phe 
    1055                 1060                 1065             


Ile Ile  Met Val Ser Ala Ser  Val Phe Val Gly Leu  Val Ile Phe 
    1070                 1075                 1080             


Tyr Ile  Ala Phe Cys Leu Leu  Trp Pro Leu Val Val  Lys Gly Cys 
    1085                 1090                 1095             


Thr Met  Ile Arg Trp Lys Ile  Asn Asn Leu Ile Ala  Ser Glu Ser 
    1100                 1105                 1110             


Tyr Tyr  Thr Tyr Ala Ser Ile  Ser Gly Ile Ser Ser  Met Pro Ser 
    1115                 1120                 1125             


Leu Arg  His Ser Arg Met Gly  Ser Met Phe Ser Ser  Arg Met Thr 
    1130                 1135                 1140             


Glu Asp  Arg Ala Glu Pro Lys  Glu Ala Val Glu Arg  Gln Leu Met 
    1145                 1150                 1155             


Thr 
    


<210>  2069
<211>  292
<212>  PRT
<213>  Homo Sapiens

<400>  2069

Met Cys Gly Pro Ala Met Phe Pro Ala Gly Pro Pro Trp Pro Arg Val 
1               5                   10                  15      


Arg Val Val Gln Val Leu Trp Ala Leu Leu Ala Val Leu Leu Ala Ser 
            20                  25                  30          


Trp Arg Leu Trp Ala Ile Lys Asp Phe Gln Glu Cys Thr Trp Gln Val 
        35                  40                  45              


Val Leu Asn Glu Phe Lys Arg Val Gly Glu Ser Gly Val Ser Asp Ser 
    50                  55                  60                  


Phe Phe Glu Gln Glu Pro Val Asp Thr Val Ser Ser Leu Phe His Met 
65                  70                  75                  80  


Leu Val Asp Ser Pro Ile Asp Pro Ser Glu Lys Tyr Leu Gly Phe Pro 
                85                  90                  95      


Tyr Tyr Leu Lys Ile Asn Tyr Ser Cys Glu Glu Lys Ser Pro Val Asn 
            100                 105                 110         


Phe Tyr Arg Trp Lys Ile Glu Gln Leu Gln Ile Gln Met Glu Ala Ala 
        115                 120                 125             


Pro Phe Arg Ser Lys Glu Pro Cys Met Ala Glu Glu Val Cys Ser Met 
    130                 135                 140                 


Ser Trp Tyr Thr Pro Met Pro Ile Lys Lys Gly Ser Val Val Met Arg 
145                 150                 155                 160 


Val Asp Ile Ser Ser Asn Gly Leu Gly Thr Phe Ile Pro Asp Lys Arg 
                165                 170                 175     


Phe Gln Met Asn Ile Asn Gly Phe Leu Lys Arg Asp Arg Asp Asn Asn 
            180                 185                 190         


Ile Gln Phe Thr Val Gly Glu Glu Leu Phe Asn Leu Met Pro Gln Tyr 
        195                 200                 205             


Phe Val Gly Val Ser Ser Arg Pro Leu Trp His Thr Val Asp Gln Ser 
    210                 215                 220                 


Pro Val Leu Ile Leu Gly Gly Ile Pro Asn Glu Lys Tyr Val Leu Met 
225                 230                 235                 240 


Thr Asp Thr Ser Phe Lys Asp Phe Ser Leu Val Glu Ala Pro Ile Pro 
                245                 250                 255     


His Ser Met Arg Glu Thr Ala Ala Val Ala Val Gly Phe Val Ser Trp 
            260                 265                 270         


Pro Ala Ser Ala Ser Arg Ser Cys Ala Leu Cys Ile Ser Ile Ala Met 
        275                 280                 285             


Ala Leu Ser Thr 
    290         


<210>  2070
<211>  136
<212>  PRT
<213>  Homo Sapiens

<400>  2070

Met Cys Gly Pro Ala Met Phe Pro Ala Gly Pro Pro Trp Pro Arg Val 
1               5                   10                  15      


Arg Val Val Gln Val Leu Trp Ala Leu Leu Ala Val Leu Leu Ala Ser 
            20                  25                  30          


Trp Arg Leu Trp Ala Ile Lys Asp Phe Gln Glu Cys Thr Trp Gln Val 
        35                  40                  45              


Val Leu Asn Glu Phe Lys Arg Val Gly Glu Ser Gly Val Ser Asp Ser 
    50                  55                  60                  


Phe Phe Glu Gln Glu Pro Val Asp Thr Val Ser Ser Leu Phe His Met 
65                  70                  75                  80  


Leu Val Asp Ser Pro Ile Asp Pro Ser Glu Lys Tyr Leu Gly Phe Pro 
                85                  90                  95      


Tyr Tyr Leu Lys Ile Asn Tyr Ser Cys Glu Glu Lys Ser Pro Val Asn 
            100                 105                 110         


Phe Tyr Arg Trp Lys Ile Glu Gln Leu Gln Ile Gln Met Glu Ala Ala 
        115                 120                 125             


Pro Phe Arg Ser Lys Gly Ser Arg 
    130                 135     


<210>  2071
<211>  159
<212>  PRT
<213>  Homo Sapiens

<400>  2071

Met Cys Gly Pro Ala Met Phe Pro Ala Gly Pro Pro Trp Pro Arg Val 
1               5                   10                  15      


Arg Val Val Gln Val Leu Trp Ala Leu Leu Ala Val Leu Leu Ala Ser 
            20                  25                  30          


Trp Arg Leu Trp Ala Ile Lys Asp Phe Gln Glu Cys Thr Trp Gln Val 
        35                  40                  45              


Val Leu Asn Glu Phe Lys Arg Val Gly Glu Ser Gly Val Ser Asp Ser 
    50                  55                  60                  


Phe Phe Glu Gln Glu Pro Val Asp Thr Val Ser Ser Leu Phe His Met 
65                  70                  75                  80  


Leu Val Asp Ser Pro Ile Asp Pro Ser Glu Lys Tyr Leu Gly Phe Pro 
                85                  90                  95      


Tyr Tyr Leu Lys Ile Asn Tyr Ser Cys Glu Glu Lys Thr Glu Ser Cys 
            100                 105                 110         


Ala Val Ala Gln Thr Gly Val Gln Trp Arg Asp Leu Gly Ser Leu Gln 
        115                 120                 125             


Pro Pro Pro Pro Val Phe Lys Arg Cys Ser Cys Leu Gly Leu Pro Ser 
    130                 135                 140                 


Ser Trp Asn Tyr Ser Pro Leu Arg Thr Trp Cys Ala Trp Ala Thr 
145                 150                 155                 


<210>  2072
<211>  165
<212>  PRT
<213>  Homo Sapiens

<400>  2072

Arg Trp Lys Ile Glu Gln Leu Gln Ile Gln Met Glu Ala Ala Pro Phe 
1               5                   10                  15      


Arg Ser Lys Glu Pro Cys Met Ala Glu Glu Val Cys Ser Met Ser Trp 
            20                  25                  30          


Tyr Thr Pro Met Pro Ile Lys Lys Gly Ser Val Val Met Arg Val Asp 
        35                  40                  45              


Ile Ser Ser Asn Gly Leu Gly Thr Phe Ile Pro Asp Lys Arg Phe Gln 
    50                  55                  60                  


Met Asn Ile Asn Gly Phe Leu Lys Arg Asp Arg Asp Asn Asn Ile Gln 
65                  70                  75                  80  


Phe Thr Val Gly Glu Glu Leu Phe Asn Leu Met Pro Gln Tyr Phe Val 
                85                  90                  95      


Gly Val Ser Ser Arg Pro Leu Trp His Thr Val Asp Gln Ser Pro Val 
            100                 105                 110         


Leu Ile Leu Gly Gly Ile Pro Asn Glu Lys Tyr Val Leu Met Thr Asp 
        115                 120                 125             


Thr Ser Phe Lys Asp Phe Ser Leu Val Glu Ala Val Gly Phe Val Ser 
    130                 135                 140                 


Trp Pro Ala Ser Ala Ser Arg Ser Cys Ala Leu Cys Ile Ser Ile Ala 
145                 150                 155                 160 


Met Ala Leu Ser Thr 
                165 


<210>  2073
<211>  180
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2073

Xaa Arg Asn Arg Gly Ser Gly Ser Trp Ile Arg Val Leu Ala Ser Glu 
1               5                   10                  15      


Cys Ile Lys Lys Leu Cys Pro Val Tyr Phe His Ser Asn Gly Ser Glu 
            20                  25                  30          


Tyr Ile Met Ala Leu Thr Thr Gly Lys His Glu Gly Tyr Val His Phe 
        35                  40                  45              


Gly Thr Ile Arg Ala Ser Asp Asp Leu Glu Leu Leu Tyr His Ile Pro 
    50                  55                  60                  


Glu Phe Ile Pro Glu Ala Arg Gly Leu Glu Phe Leu Met Ile Leu Gly 
65                  70                  75                  80  


Thr Glu Ser Tyr Thr Ser Thr Ala Met Ala Pro Lys Gly Ile Phe Cys 
                85                  90                  95      


Asn Pro Tyr Asn Asn Leu Ile Phe Ile Trp Gly Asn Phe Leu Leu Gln 
            100                 105                 110         


Ser Ser Asn Lys Glu Asn Phe Ile Tyr Leu Ala Asp Phe Pro Lys Glu 
        115                 120                 125             


Leu Ser Ile Lys Tyr Met Ala Arg Ser Phe Arg Gly Ala Val Ala Ile 
    130                 135                 140                 


Val Thr Glu Thr Glu Glu Ile Trp Tyr Leu Leu Glu Gly Ser Tyr Arg 
145                 150                 155                 160 


Val Tyr Gln Leu Phe Pro Ser Lys Gly Trp Gln Val His Ile Ser Leu 
                165                 170                 175     


Lys Leu Met Gln 
            180 


<210>  2074
<211>  193
<212>  PRT
<213>  Homo Sapiens

<400>  2074

Met Leu Gly Val Leu Glu Leu Leu Leu Leu Gly Ala Ala Trp Leu Ala 
1               5                   10                  15      


Gly Pro Ala Arg Gly Gln Asn Glu Thr Glu Pro Ile Val Leu Glu Gly 
            20                  25                  30          


Lys Cys Leu Val Val Cys Asp Ser Asn Pro Thr Ser Asp Pro Thr Gly 
        35                  40                  45              


Thr Ala Leu Gly Ile Ser Val Arg Ser Gly Ser Ala Lys Val Ala Phe 
    50                  55                  60                  


Ser Ala Ile Arg Ser Thr Asn His Glu Pro Ser Glu Met Ser Asn Arg 
65                  70                  75                  80  


Thr Met Ile Ile Tyr Phe Asp Gln Val Leu Val Asn Ile Gly Asn Asn 
                85                  90                  95      


Phe Asp Ser Glu Arg Ser Thr Phe Ile Ala Pro Arg Lys Gly Ile Tyr 
            100                 105                 110         


Ser Phe Asn Phe His Val Val Lys Val Tyr Asn Arg Gln Thr Ile Gln 
        115                 120                 125             


Val Ser Leu Met Leu Asn Gly Trp Pro Val Ile Ser Ala Phe Ala Gly 
    130                 135                 140                 


Asp Gln Asp Val Thr Arg Glu Ala Ala Ser Asn Gly Val Leu Ile Gln 
145                 150                 155                 160 


Met Glu Lys Gly Asp Arg Ala Tyr Leu Lys Leu Glu Arg Gly Asn Leu 
                165                 170                 175     


Met Gly Gly Trp Lys Tyr Ser Thr Phe Ser Gly Phe Leu Val Phe Pro 
            180                 185                 190         


Leu 
    


<210>  2075
<211>  193
<212>  PRT
<213>  Homo Sapiens

<400>  2075

Met Leu Gly Val Leu Glu Leu Leu Leu Leu Gly Ala Ala Trp Leu Ala 
1               5                   10                  15      


Gly Pro Ala Arg Gly Gln Asn Glu Thr Glu Pro Ile Val Leu Glu Gly 
            20                  25                  30          


Lys Cys Leu Val Val Cys Asp Ser Asn Pro Thr Ser Asp Pro Thr Gly 
        35                  40                  45              


Thr Ala Leu Gly Ile Ser Val Arg Ser Gly Ser Ala Lys Val Ala Phe 
    50                  55                  60                  


Ser Ala Ile Arg Ser Thr Asn His Glu Pro Ser Glu Met Ser Asn Arg 
65                  70                  75                  80  


Thr Met Ile Ile Tyr Phe Asp Gln Val Leu Val Asn Ile Gly Asn Asn 
                85                  90                  95      


Phe Asp Ser Glu Arg Ser Thr Phe Ile Ala Pro Arg Lys Gly Ile Tyr 
            100                 105                 110         


Ser Phe Asn Phe His Val Val Lys Val Tyr Asn Arg Gln Thr Ile Gln 
        115                 120                 125             


Val Ser Leu Met Leu Asn Gly Trp Pro Val Ile Ser Ala Phe Ala Gly 
    130                 135                 140                 


Asp Gln Asp Val Thr Arg Glu Ala Ala Ser Asn Gly Val Leu Ile Gln 
145                 150                 155                 160 


Met Glu Lys Gly Asp Arg Ala Tyr Leu Lys Leu Glu Arg Gly Asn Leu 
                165                 170                 175     


Met Gly Gly Trp Lys Tyr Ser Thr Phe Ser Gly Phe Leu Val Phe Pro 
            180                 185                 190         


Leu 
    


<210>  2076
<211>  140
<212>  PRT
<213>  Homo Sapiens

<400>  2076

Met Leu Gly Val Leu Glu Leu Leu Leu Leu Gly Ala Ala Trp Leu Ala 
1               5                   10                  15      


Gly Pro Ala Arg Gly Gln Asn Glu Thr Glu Pro Ile Val Leu Glu Gly 
            20                  25                  30          


Lys Cys Leu Val Val Cys Asp Ser Asn Pro Thr Ser Asp Pro Thr Gly 
        35                  40                  45              


Thr Ala Leu Gly Ile Ser Val Arg Ser Gly Ser Ala Lys Val Ala Phe 
    50                  55                  60                  


Ser Ala Ile Arg Ser Thr Asn His Glu Pro Ser Glu Met Ser Asn Arg 
65                  70                  75                  80  


Thr Met Ile Ile Tyr Phe Asp Gln Val Ser Val Pro Ser Ser Arg Gly 
                85                  90                  95      


Val Gln Ile Gly Leu Val Lys Glu Gly Trp Met Glu Asp Arg Cys Pro 
            100                 105                 110         


Val Leu Ser Lys Gly Ser Ala Glu Ala Arg Gly Arg Gln Ser Gly Thr 
        115                 120                 125             


Asp Ser Cys Pro Leu Pro Phe Val Pro Val Ser Leu 
    130                 135                 140 


<210>  2077
<211>  110
<212>  PRT
<213>  Homo Sapiens

<400>  2077

Met Asp Trp Asp Lys Val Leu Val Asn Ile Gly Asn His Phe Asp Leu 
1               5                   10                  15      


Ala Ser Ser Ile Phe Val Ala Pro Arg Lys Gly Ile Tyr Ser Phe Ser 
            20                  25                  30          


Phe His Val Val Lys Val Tyr Asn Arg Gln Thr Ile Gln Val Ser Leu 
        35                  40                  45              


Met Gln Asn Gly Tyr Pro Val Ile Ser Ala Phe Ala Gly Asp Gln Asp 
    50                  55                  60                  


Val Thr Arg Glu Ala Ala Ser Asn Gly Val Leu Leu Leu Met Glu Arg 
65                  70                  75                  80  


Glu Asp Lys Val His Leu Lys Leu Glu Arg Gly Asn Leu Met Gly Gly 
                85                  90                  95      


Trp Lys Tyr Ser Thr Phe Ser Gly Phe Leu Val Phe Pro Leu 
            100                 105                 110 


<210>  2078
<211>  108
<212>  PRT
<213>  Homo Sapiens

<400>  2078

Met Phe Gln Val Leu Val Asn Ile Gly Asn His Phe Asp Leu Ala Ser 
1               5                   10                  15      


Ser Ile Phe Val Ala Pro Arg Lys Gly Ile Tyr Ser Phe Ser Phe His 
            20                  25                  30          


Val Val Lys Val Tyr Asn Arg Gln Thr Ile Gln Val Ser Leu Met Gln 
        35                  40                  45              


Asn Gly Tyr Pro Val Ile Ser Ala Phe Ala Gly Asp Gln Asp Val Thr 
    50                  55                  60                  


Arg Glu Ala Ala Ser Asn Gly Val Leu Leu Leu Met Glu Arg Glu Asp 
65                  70                  75                  80  


Lys Val His Leu Lys Leu Glu Arg Gly Asn Leu Met Gly Gly Trp Lys 
                85                  90                  95      


Tyr Ser Thr Phe Ser Gly Phe Leu Val Phe Pro Leu 
            100                 105             


<210>  2079
<211>  224
<212>  PRT
<213>  Homo Sapiens

<400>  2079

Met Gln Ala Pro Gly Arg Gly Pro Leu Gly Leu Arg Leu Met Met Pro 
1               5                   10                  15      


Gly Arg Arg Gly Ala Leu Arg Glu Pro Gly Gly Cys Gly Ser Cys Leu 
            20                  25                  30          


Gly Val Ala Leu Ala Leu Leu Leu Leu Leu Leu Pro Ala Cys Cys Pro 
        35                  40                  45              


Val Arg Ala Gln Asn Asp Thr Glu Pro Ile Val Leu Glu Gly Lys Cys 
    50                  55                  60                  


Leu Val Val Cys Asp Ser Ser Pro Ser Ala Asp Gly Ala Val Thr Ser 
65                  70                  75                  80  


Ser Leu Gly Ile Ser Val Arg Ser Gly Ser Ala Lys Val Ala Phe Ser 
                85                  90                  95      


Ala Thr Arg Ser Thr Asn His Glu Pro Ser Glu Met Ser Asn Arg Thr 
            100                 105                 110         


Met Thr Ile Tyr Phe Asp Gln Val Leu Val Asn Ile Gly Asn His Phe 
        115                 120                 125             


Asp Leu Ala Ser Ser Ile Phe Val Ala Pro Arg Lys Gly Ile Tyr Ser 
    130                 135                 140                 


Phe Ser Phe His Val Val Lys Val Tyr Asn Arg Gln Thr Ile Gln Val 
145                 150                 155                 160 


Ser Leu Met Gln Asn Gly Tyr Pro Val Ile Ser Ala Phe Ala Gly Asp 
                165                 170                 175     


Gln Asp Val Thr Arg Glu Ala Ala Ser Asn Gly Val Leu Leu Leu Met 
            180                 185                 190         


Glu Arg Glu Asp Lys Val His Leu Lys Leu Glu Arg Gly Asn Leu Met 
        195                 200                 205             


Gly Gly Trp Lys Tyr Ser Thr Phe Ser Gly Phe Leu Val Phe Pro Leu 
    210                 215                 220                 


<210>  2080
<211>  224
<212>  PRT
<213>  Homo Sapiens

<400>  2080

Met Gln Ala Pro Gly Arg Gly Pro Leu Gly Leu Arg Leu Met Met Pro 
1               5                   10                  15      


Gly Arg Arg Gly Ala Leu Arg Glu Pro Gly Gly Cys Gly Ser Cys Leu 
            20                  25                  30          


Gly Val Ala Leu Ala Leu Leu Leu Leu Leu Leu Pro Ala Cys Cys Pro 
        35                  40                  45              


Val Arg Ala Gln Asn Asp Thr Glu Pro Ile Val Leu Glu Gly Lys Cys 
    50                  55                  60                  


Leu Val Val Cys Asp Ser Ser Pro Ser Ala Asp Gly Ala Val Thr Ser 
65                  70                  75                  80  


Ser Leu Gly Ile Ser Val Arg Ser Gly Ser Ala Lys Val Ala Phe Ser 
                85                  90                  95      


Ala Thr Arg Ser Thr Asn His Glu Pro Ser Glu Met Ser Asn Arg Thr 
            100                 105                 110         


Met Thr Ile Tyr Phe Asp Gln Val Leu Val Asn Ile Gly Asn His Phe 
        115                 120                 125             


Asp Leu Ala Ser Ser Ile Phe Val Ala Pro Arg Lys Gly Ile Tyr Ser 
    130                 135                 140                 


Phe Ser Phe His Val Val Lys Val Tyr Asn Arg Gln Thr Ile Gln Val 
145                 150                 155                 160 


Ser Leu Met Gln Asn Gly Tyr Pro Val Ile Ser Ala Phe Ala Gly Asp 
                165                 170                 175     


Gln Asp Val Thr Arg Glu Ala Ala Ser Asn Gly Val Leu Leu Leu Met 
            180                 185                 190         


Glu Arg Glu Asp Lys Val His Leu Lys Leu Glu Arg Gly Asn Leu Met 
        195                 200                 205             


Gly Gly Trp Lys Tyr Ser Thr Phe Ser Gly Phe Leu Val Phe Pro Leu 
    210                 215                 220                 


<210>  2081
<211>  205
<212>  PRT
<213>  Homo Sapiens

<400>  2081

Met Leu Gly Ala Lys Pro His Trp Leu Pro Gly Pro Leu His Ser Pro 
1               5                   10                  15      


Gly Leu Pro Leu Val Leu Val Leu Leu Ala Leu Gly Ala Gly Trp Ala 
            20                  25                  30          


Gln Glu Gly Ser Glu Pro Val Leu Leu Glu Gly Glu Cys Leu Val Val 
        35                  40                  45              


Cys Glu Pro Gly Arg Ala Ala Ala Gly Gly Pro Gly Gly Ala Ala Leu 
    50                  55                  60                  


Gly Glu Ala Pro Pro Gly Arg Val Ala Phe Ala Ala Val Arg Ser His 
65                  70                  75                  80  


His His Glu Pro Ala Gly Glu Thr Gly Asn Gly Thr Ser Gly Ala Ile 
                85                  90                  95      


Tyr Phe Asp Gln Val Leu Val Asn Glu Gly Gly Gly Phe Asp Arg Ala 
            100                 105                 110         


Ser Gly Ser Phe Val Ala Pro Val Arg Gly Val Tyr Ser Phe Arg Phe 
        115                 120                 125             


His Val Val Lys Val Tyr Asn Arg Gln Thr Val Gln Val Ser Leu Met 
    130                 135                 140                 


Leu Asn Thr Trp Pro Val Ile Ser Ala Phe Ala Asn Asp Pro Asp Val 
145                 150                 155                 160 


Thr Arg Glu Ala Ala Thr Ser Ser Val Leu Leu Pro Leu Asp Pro Gly 
                165                 170                 175     


Asp Arg Val Ser Leu Arg Leu Arg Arg Gly Asn Leu Leu Gly Gly Trp 
            180                 185                 190         


Lys Tyr Ser Ser Phe Ser Gly Phe Leu Ile Phe Pro Leu 
        195                 200                 205 


<210>  2082
<211>  154
<212>  PRT
<213>  Homo Sapiens

<400>  2082

Met Trp Gly Leu Ser Gly Gln Ser Phe Gly Arg Thr Leu Thr Pro Thr 
1               5                   10                  15      


Leu Lys Met Arg Ser Thr Trp Gly Cys Cys Ser Arg Thr Leu Phe Ser 
            20                  25                  30          


Ala Ser Ala Asp Thr Ala Lys Arg Ser Gly Asp Ala Gly Arg Ala Pro 
        35                  40                  45              


Gln Val Leu Val Asn Glu Gly Gly Gly Phe Asp Arg Ala Ser Gly Ser 
    50                  55                  60                  


Phe Val Ala Pro Val Arg Gly Val Tyr Ser Phe Arg Phe His Val Val 
65                  70                  75                  80  


Lys Val Tyr Asn Arg Gln Thr Val Gln Val Ser Leu Met Leu Asn Thr 
                85                  90                  95      


Trp Pro Val Ile Ser Ala Phe Ala Asn Asp Pro Asp Val Thr Arg Glu 
            100                 105                 110         


Ala Ala Thr Ser Ser Val Leu Leu Pro Leu Asp Pro Gly Asp Arg Val 
        115                 120                 125             


Ser Leu Arg Leu Arg Arg Gly Asn Leu Leu Gly Gly Trp Lys Tyr Ser 
    130                 135                 140                 


Ser Phe Ser Gly Phe Leu Ile Phe Pro Leu 
145                 150                 


<210>  2083
<211>  201
<212>  PRT
<213>  Homo Sapiens

<400>  2083

Met Gly Ser Gly Arg Arg Ala Leu Ser Ala Val Pro Ala Val Leu Leu 
1               5                   10                  15      


Val Leu Thr Leu Pro Gly Leu Pro Val Trp Ala Gln Asn Asp Thr Glu 
            20                  25                  30          


Pro Ile Val Leu Glu Gly Lys Cys Leu Val Val Cys Asp Ser Asn Pro 
        35                  40                  45              


Ala Thr Asp Ser Lys Gly Ser Ser Ser Ser Pro Leu Gly Ile Ser Val 
    50                  55                  60                  


Arg Ala Ala Asn Ser Lys Val Ala Phe Ser Ala Val Arg Ser Thr Asn 
65                  70                  75                  80  


His Glu Pro Ser Glu Met Ser Asn Lys Thr Arg Ile Ile Tyr Phe Asp 
                85                  90                  95      


Gln Ile Leu Val Asn Val Gly Asn Phe Phe Thr Leu Glu Ser Val Phe 
            100                 105                 110         


Val Ala Pro Arg Lys Gly Ile Tyr Ser Phe Ser Phe His Val Ile Lys 
        115                 120                 125             


Val Tyr Gln Ser Gln Thr Ile Gln Val Asn Leu Met Leu Asn Gly Lys 
    130                 135                 140                 


Pro Val Ile Ser Ala Phe Ala Gly Asp Lys Asp Val Thr Arg Glu Ala 
145                 150                 155                 160 


Ala Thr Asn Gly Val Leu Leu Tyr Leu Asp Lys Glu Asp Lys Val Tyr 
                165                 170                 175     


Leu Lys Leu Glu Lys Gly Asn Leu Val Gly Gly Trp Gln Tyr Ser Thr 
            180                 185                 190         


Phe Ser Gly Phe Leu Val Phe Pro Leu 
        195                 200     


<210>  2084
<211>  46
<212>  PRT
<213>  Homo Sapiens

<400>  2084

Met Val Lys Ala Gly Thr Cys Cys Ala Thr Cys Lys Glu Phe Tyr Gln 
1               5                   10                  15      


Met Lys Gln Thr Val Leu Gln Leu Lys Gln Lys Ile Ala Leu Leu Pro 
            20                  25                  30          


Asn Asn Ala Ala Asp Leu Gly Lys Tyr Ile Thr Gly Asp Lys 
        35                  40                  45      


<210>  2085
<211>  406
<212>  PRT
<213>  Homo Sapiens

<400>  2085

Met Val Pro Pro Pro Pro Ser Arg Gly Gly Ala Ala Arg Gly Gln Leu 
1               5                   10                  15      


Gly Arg Ser Leu Gly Pro Leu Leu Leu Leu Leu Ala Leu Gly His Thr 
            20                  25                  30          


Trp Thr Tyr Arg Glu Glu Pro Glu Asp Gly Asp Arg Glu Ile Cys Ser 
        35                  40                  45              


Glu Ser Lys Ile Ala Thr Thr Lys Tyr Pro Cys Leu Lys Ser Ser Gly 
    50                  55                  60                  


Glu Leu Thr Thr Cys Tyr Arg Lys Lys Cys Cys Lys Gly Tyr Lys Phe 
65                  70                  75                  80  


Val Leu Gly Gln Cys Ile Pro Glu Asp Tyr Asp Val Cys Ala Glu Ala 
                85                  90                  95      


Pro Cys Glu Gln Gln Cys Thr Asp Asn Phe Gly Arg Val Leu Cys Thr 
            100                 105                 110         


Cys Tyr Pro Gly Tyr Arg Tyr Asp Arg Glu Arg His Arg Lys Arg Glu 
        115                 120                 125             


Lys Pro Tyr Cys Leu Asp Ile Asp Glu Cys Ala Ser Ser Asn Gly Thr 
    130                 135                 140                 


Leu Cys Ala His Ile Cys Ile Asn Thr Leu Gly Ser Tyr Arg Cys Glu 
145                 150                 155                 160 


Cys Arg Glu Gly Tyr Ile Arg Glu Asp Asp Gly Lys Thr Cys Thr Arg 
                165                 170                 175     


Gly Asp Lys Tyr Pro Asn Asp Thr Gly His Glu Lys Ser Glu Asn Met 
            180                 185                 190         


Val Lys Ala Gly Thr Cys Cys Ala Thr Cys Lys Glu Phe Tyr Gln Met 
        195                 200                 205             


Lys Gln Thr Val Leu Gln Leu Lys Gln Lys Ile Ala Leu Leu Pro Asn 
    210                 215                 220                 


Asn Ala Ala Asp Leu Gly Lys Tyr Ile Thr Gly Asp Lys Val Leu Ala 
225                 230                 235                 240 


Ser Asn Thr Tyr Leu Pro Gly Pro Pro Gly Leu Pro Gly Gly Gln Gly 
                245                 250                 255     


Pro Pro Gly Ser Pro Gly Pro Lys Gly Ser Pro Gly Phe Pro Gly Met 
            260                 265                 270         


Pro Gly Pro Pro Gly Gln Pro Gly Pro Arg Gly Ser Met Gly Pro Met 
        275                 280                 285             


Gly Pro Ser Pro Asp Leu Ser His Ile Lys Gln Gly Arg Arg Gly Pro 
    290                 295                 300                 


Val Gly Pro Pro Gly Ala Pro Gly Arg Asp Gly Ser Lys Gly Glu Arg 
305                 310                 315                 320 


Gly Ala Pro Gly Pro Arg Gly Ser Pro Gly Pro Pro Gly Ser Phe Asp 
                325                 330                 335     


Phe Leu Leu Leu Met Leu Ala Asp Ile Arg Asn Asp Ile Thr Glu Leu 
            340                 345                 350         


Gln Glu Lys Val Phe Gly His Arg Thr His Ser Ser Ala Glu Glu Phe 
        355                 360                 365             


Pro Leu Pro Gln Glu Phe Pro Ser Tyr Pro Glu Ala Met Asp Leu Gly 
    370                 375                 380                 


Ser Gly Asp Asp His Pro Arg Arg Thr Glu Thr Arg Asp Leu Arg Ala 
385                 390                 395                 400 


Pro Arg Asp Phe Tyr Pro 
                405     


<210>  2086
<211>  336
<212>  PRT
<213>  Homo Sapiens

<400>  2086

Arg Lys Lys Cys Cys Lys Gly Tyr Lys Phe Val Leu Gly Gln Cys Ile 
1               5                   10                  15      


Pro Glu Asp Tyr Asp Val Cys Ala Glu Ala Pro Cys Glu Gln Gln Cys 
            20                  25                  30          


Thr Asp Asn Phe Gly Arg Val Leu Cys Thr Cys Tyr Pro Gly Tyr Arg 
        35                  40                  45              


Tyr Asp Arg Glu Arg His Arg Lys Arg Glu Lys Pro Tyr Cys Leu Asp 
    50                  55                  60                  


Ile Asp Glu Cys Ala Ser Ser Asn Gly Thr Leu Cys Ala His Ile Cys 
65                  70                  75                  80  


Ile Asn Thr Leu Gly Ser Tyr Arg Cys Glu Cys Arg Glu Gly Tyr Ile 
                85                  90                  95      


Arg Glu Asp Asp Gly Lys Thr Cys Thr Arg Gly Asp Lys Tyr Pro Asn 
            100                 105                 110         


Asp Thr Gly His Glu Lys Ser Glu Asn Met Val Lys Ala Gly Thr Cys 
        115                 120                 125             


Cys Ala Thr Cys Lys Glu Phe Tyr Gln Met Lys Gln Thr Val Leu Gln 
    130                 135                 140                 


Leu Lys Gln Lys Ile Ala Leu Leu Pro Asn Asn Ala Ala Asp Leu Gly 
145                 150                 155                 160 


Lys Tyr Ile Thr Gly Asp Lys Val Leu Ala Ser Asn Thr Tyr Leu Pro 
                165                 170                 175     


Gly Pro Pro Gly Leu Pro Gly Gly Gln Gly Pro Pro Gly Ser Pro Gly 
            180                 185                 190         


Pro Lys Gly Ser Pro Gly Phe Pro Gly Met Pro Gly Pro Pro Gly Gln 
        195                 200                 205             


Pro Gly Pro Arg Gly Ser Met Gly Pro Met Gly Pro Ser Pro Asp Leu 
    210                 215                 220                 


Ser His Ile Lys Gln Gly Arg Arg Gly Pro Val Gly Pro Pro Gly Ala 
225                 230                 235                 240 


Pro Gly Arg Asp Gly Ser Lys Gly Glu Arg Gly Ala Pro Gly Pro Arg 
                245                 250                 255     


Gly Ser Pro Gly Pro Pro Gly Ser Phe Asp Phe Leu Leu Leu Met Leu 
            260                 265                 270         


Ala Asp Ile Arg Asn Asp Ile Thr Glu Leu Gln Glu Lys Val Phe Gly 
        275                 280                 285             


His Arg Thr His Ser Ser Ala Glu Glu Phe Pro Leu Pro Gln Glu Phe 
    290                 295                 300                 


Pro Ser Tyr Pro Glu Ala Met Asp Leu Gly Ser Gly Asp Asp His Pro 
305                 310                 315                 320 


Arg Arg Thr Glu Thr Arg Asp Leu Arg Ala Pro Arg Asp Phe Tyr Pro 
                325                 330                 335     


<210>  2087
<211>  529
<212>  PRT
<213>  Homo Sapiens

<400>  2087

Met Ala Ala Leu Thr Thr Val Val Val Ala Ala Ala Ala Thr Ala Val 
1               5                   10                  15      


Ala Gly Ala Val Ala Gly Ala Gly Ala Ala Thr Gly Thr Gly Val Gly 
            20                  25                  30          


Ala Thr Pro Ala Pro Gln Gln Ser Asp Gly Cys Phe Ser Thr Ser Gly 
        35                  40                  45              


Gly Ile Arg Pro Phe His Leu Gln Asn Trp Lys Gln Lys Val Asn Gln 
    50                  55                  60                  


Thr Lys Lys Ala Glu Phe Val Arg Thr Ala Glu Lys Phe Lys Asn Gln 
65                  70                  75                  80  


Val Ile Asn Met Glu Lys Asp Lys His Ser His Phe Tyr Asn Gln Lys 
                85                  90                  95      


Ser Asp Phe Arg Ile Glu His Ser Met Leu Glu Glu Leu Glu Asn Lys 
            100                 105                 110         


Leu Ile His Ser Arg Lys Thr Glu Arg Ala Lys Ile Gln Gln Gln Leu 
        115                 120                 125             


Ala Lys Ile His Asn Asn Val Lys Lys Leu Gln His Gln Leu Lys Asp 
    130                 135                 140                 


Val Lys Pro Thr Pro Asp Phe Val Glu Lys Leu Arg Glu Met Met Glu 
145                 150                 155                 160 


Glu Ile Glu Asn Ala Ile Asn Thr Phe Lys Glu Glu Gln Arg Leu Ile 
                165                 170                 175     


Tyr Glu Glu Leu Ile Lys Glu Glu Lys Thr Thr Asn Asn Glu Leu Ser 
            180                 185                 190         


Ala Ile Ser Arg Lys Ile Asp Thr Trp Ala Leu Gly Asn Ser Glu Thr 
        195                 200                 205             


Glu Lys Ala Phe Arg Ala Ile Ser Ser Lys Val Pro Val Asp Lys Val 
    210                 215                 220                 


Thr Pro Ser Thr Leu Pro Glu Glu Val Leu Asp Phe Glu Lys Phe Leu 
225                 230                 235                 240 


Gln Gln Thr Gly Gly Arg Gln Gly Ala Trp Asp Asp Tyr Asp His Gln 
                245                 250                 255     


Asn Phe Val Lys Val Arg Asn Lys His Lys Gly Lys Pro Thr Phe Met 
            260                 265                 270         


Glu Glu Val Leu Glu His Leu Pro Gly Lys Thr Gln Asp Glu Val Gln 
        275                 280                 285             


Gln His Glu Lys Trp Tyr Gln Lys Phe Leu Ala Leu Glu Glu Arg Lys 
    290                 295                 300                 


Lys Glu Ser Ile Gln Ile Trp Lys Thr Lys Lys Gln Gln Lys Arg Glu 
305                 310                 315                 320 


Glu Ile Phe Lys Leu Lys Glu Lys Ala Asp Asn Thr Pro Val Leu Phe 
                325                 330                 335     


His Asn Lys Gln Glu Asp Asn Gln Lys Gln Lys Glu Glu Gln Arg Lys 
            340                 345                 350         


Lys Gln Lys Leu Ala Val Glu Ala Trp Lys Lys Gln Lys Ser Ile Glu 
        355                 360                 365             


Met Ser Met Lys Cys Ala Ser Gln Leu Lys Glu Glu Glu Glu Lys Glu 
    370                 375                 380                 


Lys Lys His Gln Lys Glu Arg Gln Arg Gln Phe Lys Leu Lys Leu Leu 
385                 390                 395                 400 


Leu Glu Ser Tyr Thr Gln Gln Lys Lys Glu Gln Glu Glu Phe Leu Arg 
                405                 410                 415     


Leu Glu Lys Glu Ile Arg Glu Lys Ala Glu Lys Ala Glu Lys Arg Lys 
            420                 425                 430         


Asn Ala Ala Asp Glu Ile Ser Arg Phe Gln Glu Arg Asp Leu His Lys 
        435                 440                 445             


Leu Glu Leu Lys Ile Leu Asp Arg Gln Ala Lys Glu Asp Glu Lys Ser 
    450                 455                 460                 


Gln Lys Gln Arg Arg Leu Ala Lys Leu Lys Glu Lys Val Glu Asn Asn 
465                 470                 475                 480 


Val Ser Arg Asp Pro Ser Arg Leu Tyr Lys Pro Thr Lys Gly Trp Glu 
                485                 490                 495     


Glu Arg Thr Lys Lys Ile Gly Pro Thr Gly Ser Gly Pro Leu Leu His 
            500                 505                 510         


Ile Pro His Arg Ala Ile Pro Thr Trp Arg Gln Gly Ile Gln Arg Arg 
        515                 520                 525             


Val 
    


<210>  2088
<211>  446
<212>  PRT
<213>  Homo Sapiens

<400>  2088

Met Glu Lys Asp Lys His Ser His Phe Tyr Asn Gln Lys Ser Asp Phe 
1               5                   10                  15      


Arg Ile Glu His Ser Met Leu Glu Glu Leu Glu Asn Lys Leu Ile His 
            20                  25                  30          


Ser Arg Lys Thr Glu Arg Ala Lys Ile Gln Gln Gln Leu Ala Lys Ile 
        35                  40                  45              


His Asn Asn Val Lys Lys Leu Gln His Gln Leu Lys Asp Val Lys Pro 
    50                  55                  60                  


Thr Pro Asp Phe Val Glu Lys Leu Arg Glu Met Met Glu Glu Ile Glu 
65                  70                  75                  80  


Asn Ala Ile Asn Thr Phe Lys Glu Glu Gln Arg Leu Ile Tyr Glu Glu 
                85                  90                  95      


Leu Ile Lys Glu Glu Lys Thr Thr Asn Asn Glu Leu Ser Ala Ile Ser 
            100                 105                 110         


Arg Lys Ile Asp Thr Trp Ala Leu Gly Asn Ser Glu Thr Glu Lys Ala 
        115                 120                 125             


Phe Arg Ala Ile Ser Ser Lys Val Pro Val Asp Lys Val Thr Pro Ser 
    130                 135                 140                 


Thr Leu Pro Glu Glu Val Leu Asp Phe Glu Lys Phe Leu Gln Gln Thr 
145                 150                 155                 160 


Gly Gly Arg Gln Gly Ala Trp Asp Asp Tyr Asp His Gln Asn Phe Val 
                165                 170                 175     


Lys Val Arg Asn Lys His Lys Gly Lys Pro Thr Phe Met Glu Glu Val 
            180                 185                 190         


Leu Glu His Leu Pro Gly Lys Thr Gln Asp Glu Val Gln Gln His Glu 
        195                 200                 205             


Lys Trp Tyr Gln Lys Phe Leu Ala Leu Glu Glu Arg Lys Lys Glu Ser 
    210                 215                 220                 


Ile Gln Ile Trp Lys Thr Lys Lys Gln Gln Lys Arg Glu Glu Ile Phe 
225                 230                 235                 240 


Lys Leu Lys Glu Lys Ala Asp Asn Thr Pro Val Leu Phe His Asn Lys 
                245                 250                 255     


Gln Glu Asp Asn Gln Lys Gln Lys Glu Glu Gln Arg Lys Lys Gln Lys 
            260                 265                 270         


Leu Ala Val Glu Ala Trp Lys Lys Gln Lys Ser Ile Glu Met Ser Met 
        275                 280                 285             


Lys Cys Ala Ser Gln Leu Lys Glu Glu Glu Glu Lys Glu Lys Lys His 
    290                 295                 300                 


Gln Lys Glu Arg Gln Arg Gln Phe Lys Leu Lys Leu Leu Leu Glu Ser 
305                 310                 315                 320 


Tyr Thr Gln Gln Lys Lys Glu Gln Glu Glu Phe Leu Arg Leu Glu Lys 
                325                 330                 335     


Glu Ile Arg Glu Lys Ala Glu Lys Ala Glu Lys Arg Lys Asn Ala Ala 
            340                 345                 350         


Asp Glu Ile Ser Arg Phe Gln Glu Arg Asp Leu His Lys Leu Glu Leu 
        355                 360                 365             


Lys Ile Leu Asp Arg Gln Ala Lys Glu Asp Glu Lys Ser Gln Lys Gln 
    370                 375                 380                 


Arg Arg Leu Ala Lys Leu Lys Glu Lys Val Glu Asn Asn Val Ser Arg 
385                 390                 395                 400 


Asp Pro Ser Arg Leu Tyr Lys Pro Thr Lys Gly Trp Glu Glu Arg Thr 
                405                 410                 415     


Lys Lys Ile Gly Pro Thr Gly Ser Gly Pro Leu Leu His Ile Pro His 
            420                 425                 430         


Arg Ala Ile Pro Thr Trp Arg Gln Gly Ile Gln Arg Arg Val 
        435                 440                 445     


<210>  2089
<211>  414
<212>  PRT
<213>  Homo Sapiens

<400>  2089

Met Glu Lys Asp Lys His Ser His Phe Tyr Asn Gln Lys Ser Asp Phe 
1               5                   10                  15      


Arg Ile Glu His Ser Met Leu Glu Glu Leu Glu Asn Lys Leu Ile His 
            20                  25                  30          


Ser Arg Lys Thr Glu Arg Ala Lys Ile Gln Gln Gln Leu Ala Lys Ile 
        35                  40                  45              


His Asn Asn Val Lys Lys Leu Gln His Gln Leu Lys Asp Val Lys Pro 
    50                  55                  60                  


Thr Pro Asp Phe Val Glu Lys Leu Arg Glu Met Met Glu Glu Ile Glu 
65                  70                  75                  80  


Asn Ala Ile Asn Thr Phe Lys Glu Glu Gln Arg Leu Ile Tyr Glu Glu 
                85                  90                  95      


Leu Ile Lys Glu Glu Lys Thr Thr Asn Asn Glu Leu Ser Ala Ile Ser 
            100                 105                 110         


Arg Lys Ile Asp Thr Trp Ala Leu Gly Asn Ser Glu Thr Glu Lys Ala 
        115                 120                 125             


Phe Arg Ala Ile Ser Ser Lys Val Pro Val Asp Lys Val Thr Pro Ser 
    130                 135                 140                 


Thr Leu Pro Glu Glu Val Leu Asp Phe Glu Lys Phe Leu Gln Gln Thr 
145                 150                 155                 160 


Gly Gly Arg Gln Gly Ala Trp Asp Asp Tyr Asp His Gln Asn Phe Val 
                165                 170                 175     


Lys Val Arg Asn Lys His Lys Gly Lys Pro Thr Phe Met Glu Glu Val 
            180                 185                 190         


Leu Glu His Leu Pro Gly Lys Thr Gln Asp Glu Val Gln Gln His Glu 
        195                 200                 205             


Lys Trp Tyr Gln Lys Phe Leu Ala Leu Glu Glu Arg Lys Lys Glu Ser 
    210                 215                 220                 


Ile Gln Ile Trp Lys Thr Lys Lys Gln Gln Lys Arg Glu Glu Ile Phe 
225                 230                 235                 240 


Lys Leu Lys Glu Lys Ala Asp Asn Thr Pro Val Leu Phe His Asn Lys 
                245                 250                 255     


Gln Glu Asp Asn Gln Lys Gln Lys Glu Glu Gln Arg Lys Lys Gln Lys 
            260                 265                 270         


Leu Ala Val Glu Ala Trp Lys Lys Gln Lys Ser Ile Glu Met Ser Met 
        275                 280                 285             


Lys Cys Ala Ser Gln Leu Lys Glu Glu Glu Glu Lys Glu Lys Lys His 
    290                 295                 300                 


Gln Lys Glu Arg Gln Arg Gln Phe Lys Leu Lys Leu Leu Leu Glu Ser 
305                 310                 315                 320 


Tyr Thr Gln Gln Lys Lys Glu Gln Glu Glu Phe Leu Arg Leu Glu Lys 
                325                 330                 335     


Glu Ile Arg Glu Lys Ala Glu Lys Ala Glu Lys Arg Lys Asn Ala Ala 
            340                 345                 350         


Asp Glu Ile Ser Arg Phe Gln Glu Arg Val Glu Asn Asn Val Ser Arg 
        355                 360                 365             


Asp Pro Ser Arg Leu Tyr Lys Pro Thr Lys Gly Trp Glu Glu Arg Thr 
    370                 375                 380                 


Lys Lys Ile Gly Pro Thr Gly Ser Gly Pro Leu Leu His Ile Pro His 
385                 390                 395                 400 


Arg Ala Ile Pro Thr Trp Arg Gln Gly Ile Gln Arg Arg Val 
                405                 410                 


<210>  2090
<211>  446
<212>  PRT
<213>  Homo Sapiens

<400>  2090

Met Glu Lys Asp Lys His Ser His Phe Tyr Asn Gln Lys Ser Asp Phe 
1               5                   10                  15      


Arg Ile Glu His Ser Met Leu Glu Glu Leu Glu Asn Lys Leu Ile His 
            20                  25                  30          


Ser Arg Lys Thr Glu Arg Ala Lys Ile Gln Gln Gln Leu Ala Lys Ile 
        35                  40                  45              


His Asn Asn Val Lys Lys Leu Gln His Gln Leu Lys Asp Val Lys Pro 
    50                  55                  60                  


Thr Pro Asp Phe Val Glu Lys Leu Arg Glu Met Met Glu Glu Ile Glu 
65                  70                  75                  80  


Asn Ala Ile Asn Thr Phe Lys Glu Glu Gln Arg Leu Ile Tyr Glu Glu 
                85                  90                  95      


Leu Ile Lys Glu Glu Lys Thr Thr Asn Asn Glu Leu Ser Ala Ile Ser 
            100                 105                 110         


Arg Lys Ile Asp Thr Trp Ala Leu Gly Asn Ser Glu Thr Glu Lys Ala 
        115                 120                 125             


Phe Arg Ala Ile Ser Ser Lys Val Pro Val Asp Lys Val Thr Pro Ser 
    130                 135                 140                 


Thr Leu Pro Glu Glu Val Leu Asp Phe Glu Lys Phe Leu Gln Gln Thr 
145                 150                 155                 160 


Gly Gly Arg Gln Gly Ala Trp Asp Asp Tyr Asp His Gln Asn Phe Val 
                165                 170                 175     


Lys Val Arg Asn Lys His Lys Gly Lys Pro Thr Phe Met Glu Glu Val 
            180                 185                 190         


Leu Glu His Leu Pro Gly Lys Thr Gln Asp Glu Val Gln Gln His Glu 
        195                 200                 205             


Lys Trp Tyr Gln Lys Phe Leu Ala Leu Glu Glu Arg Lys Lys Glu Ser 
    210                 215                 220                 


Ile Gln Ile Trp Lys Thr Lys Lys Gln Gln Lys Arg Glu Glu Ile Phe 
225                 230                 235                 240 


Lys Leu Lys Glu Lys Ala Asp Asn Thr Pro Val Leu Phe His Asn Lys 
                245                 250                 255     


Gln Glu Asp Asn Gln Lys Gln Lys Glu Glu Gln Arg Lys Lys Gln Lys 
            260                 265                 270         


Leu Ala Val Glu Ala Trp Lys Lys Gln Lys Ser Ile Glu Met Ser Met 
        275                 280                 285             


Lys Cys Ala Ser Gln Leu Lys Glu Glu Glu Glu Lys Glu Lys Lys His 
    290                 295                 300                 


Gln Lys Glu Arg Gln Arg Gln Phe Lys Leu Lys Leu Leu Leu Glu Ser 
305                 310                 315                 320 


Tyr Thr Gln Gln Lys Lys Glu Gln Glu Glu Phe Leu Arg Leu Glu Lys 
                325                 330                 335     


Glu Ile Arg Glu Lys Ala Glu Lys Ala Glu Lys Arg Lys Asn Ala Ala 
            340                 345                 350         


Asp Glu Ile Ser Arg Phe Gln Glu Arg Asp Leu His Lys Leu Glu Leu 
        355                 360                 365             


Lys Ile Leu Asp Arg Gln Ala Lys Glu Asp Glu Lys Ser Gln Lys Gln 
    370                 375                 380                 


Arg Arg Leu Ala Lys Leu Lys Glu Lys Val Glu Asn Asn Val Ser Arg 
385                 390                 395                 400 


Asp Pro Ser Arg Leu Tyr Lys Pro Thr Lys Gly Trp Glu Glu Arg Thr 
                405                 410                 415     


Lys Lys Ile Gly Pro Thr Gly Ser Gly Pro Leu Leu His Ile Pro His 
            420                 425                 430         


Arg Ala Ile Pro Thr Trp Arg Gln Gly Ile Gln Arg Arg Val 
        435                 440                 445     


<210>  2091
<211>  142
<212>  PRT
<213>  Homo Sapiens

<400>  2091

Met Met Ala Gln Lys Ser Gln Gly Ser Asp Asn Leu Gln Glu Gly Gln 
1               5                   10                  15      


Glu Lys Ser Lys Arg Glu Ile Leu Lys Cys Thr Lys Ser Ala Trp Ala 
            20                  25                  30          


Pro Leu Asp Glu Trp Leu Pro Pro Asp Pro Glu Glu Glu Ser Gln Ser 
        35                  40                  45              


Leu Thr Ile Pro Met Leu Glu Asp Ser Lys Gln Glu Ser Ile Gln Gln 
    50                  55                  60                  


Trp Leu Asp Ser Gly Phe Phe Val Ser Ala Asn Glu Asn Phe Gln Gln 
65                  70                  75                  80  


Val Ile Asp Arg Thr Val Ser Leu Tyr Glu Gln Gly Met Val Gln Met 
                85                  90                  95      


Thr Val Lys Asp Tyr Met Arg Ser Leu His Gln Phe Ser Glu Thr Pro 
            100                 105                 110         


Ile Leu Ser Arg Gly Thr Ser Phe Asn Ser Cys Tyr Ser Thr Ala Ser 
        115                 120                 125             


Val Pro Gln Ser Ile Pro Glu Trp Leu Glu Phe Trp Glu Ile 
    130                 135                 140         


<210>  2092
<211>  163
<212>  PRT
<213>  Homo Sapiens

<400>  2092

Met Met Ala Gln Lys Ser Gln Gly Ser Asp Asn Leu Gln Glu Gly Gln 
1               5                   10                  15      


Glu Lys Ser Lys Arg Glu Ile Leu Lys Cys Thr Lys Ser Ala Trp Ala 
            20                  25                  30          


Pro Leu Asp Glu Trp Leu Pro Pro Asp Pro Glu Glu Glu Ser Gln Ser 
        35                  40                  45              


Leu Thr Ile Pro Met Leu Glu Asp Ser Lys Gln Glu Ser Ile Gln Gln 
    50                  55                  60                  


Trp Leu Asp Ser Gly Phe Phe Val Ser Ala Asn Glu Asn Phe Gln Gln 
65                  70                  75                  80  


Val Ile Asp Arg Thr Val Ser Leu Tyr Glu Gln Gly Met Val Gln Met 
                85                  90                  95      


Thr Val Lys Asp Tyr Met Arg Ser Leu His Gln Phe Ser Glu Thr Pro 
            100                 105                 110         


Ile Leu Ser Arg Gly Thr Ser Phe Asn Ser Cys Tyr Ser Thr Ala Ser 
        115                 120                 125             


Val Pro Gln Ser Ile Pro Glu Trp Leu Glu Phe Trp Glu Ile Asp Pro 
    130                 135                 140                 


Val Glu Ile Leu Leu Asp Leu Gly Phe Gly Ala Asp Glu Pro Asp Ile 
145                 150                 155                 160 


Cys Met Gln 
            


<210>  2093
<211>  168
<212>  PRT
<213>  Homo Sapiens

<400>  2093

Met Met Ala Gln Lys Ser Gln Gly Ser Asp Asn Leu Gln Glu Gly Gln 
1               5                   10                  15      


Glu Lys Ser Lys Arg Glu Ile Leu Lys Cys Thr Lys Ser Ala Trp Ala 
            20                  25                  30          


Pro Leu Asp Glu Trp Leu Pro Pro Asp Pro Glu Glu Glu Ser Gln Ser 
        35                  40                  45              


Leu Thr Ile Pro Met Leu Glu Asp Ser Lys Gln Glu Ser Ile Gln Gln 
    50                  55                  60                  


Trp Leu Asp Ser Gly Phe Phe Val Ser Ala Asn Glu Asn Phe Gln Gln 
65                  70                  75                  80  


Val Ile Asp Arg Thr Val Ser Leu Tyr Glu Gln Gly Met Val Gln Met 
                85                  90                  95      


Thr Val Lys Asp Tyr Met Arg Ser Leu His Gln Phe Ser Glu Thr Pro 
            100                 105                 110         


Ile Leu Ser Arg Gly Thr Ser Phe Asn Ser Cys Tyr Ser Thr Ala Ser 
        115                 120                 125             


Val Pro Gln Ser Ile Pro Glu Trp Leu Glu Phe Trp Glu Ile Asp Pro 
    130                 135                 140                 


Val Glu Ile Leu Leu Asp Leu Gly Phe Gly Ala Asp Glu Pro Asp Ile 
145                 150                 155                 160 


Cys Met Gln Ile Pro Ala Arg Phe 
                165             


<210>  2094
<211>  896
<212>  PRT
<213>  Homo Sapiens

<400>  2094

Met Met Ala Gln Lys Ser Gln Gly Ser Asp Asn Leu Gln Glu Gly Gln 
1               5                   10                  15      


Glu Lys Ser Lys Arg Glu Ile Leu Lys Cys Thr Lys Ser Ala Trp Ala 
            20                  25                  30          


Pro Leu Asp Glu Trp Leu Pro Pro Asp Pro Glu Glu Glu Ser Gln Ser 
        35                  40                  45              


Leu Thr Ile Pro Met Leu Glu Asp Ser Lys Gln Glu Ser Ile Gln Gln 
    50                  55                  60                  


Trp Leu Asp Ser Gly Phe Phe Val Ser Ala Asn Glu Asn Phe Gln Gln 
65                  70                  75                  80  


Val Ile Asp Arg Thr Val Ser Leu Tyr Glu Gln Gly Met Val Gln Met 
                85                  90                  95      


Thr Val Lys Asp Tyr Met Arg Ser Leu His Gln Phe Ser Glu Thr Pro 
            100                 105                 110         


Ile Leu Ser Arg Gly Thr Ser Phe Asn Ser Cys Tyr Ser Thr Ala Ser 
        115                 120                 125             


Val Pro Gln Ser Ile Pro Glu Trp Leu Glu Phe Trp Glu Ile Asp Pro 
    130                 135                 140                 


Val Glu Ile Leu Leu Asp Leu Gly Phe Gly Ala Asp Glu Pro Asp Ile 
145                 150                 155                 160 


Cys Met Gln Ile Pro Ala Arg Phe Leu Gly Cys Gly Ser Ala Ala Arg 
                165                 170                 175     


Gly Ile Asn Ile Arg Val Phe Leu Glu Ala Gln Lys Gln Arg Met Asp 
            180                 185                 190         


Ile Glu Asn Pro Asn Leu Tyr Gly Arg Phe Arg Gln Leu Glu Ile Leu 
        195                 200                 205             


Asp His Val Thr Asn Ala Phe Ser Ser Leu Leu Ser Asp Val Ser Ile 
    210                 215                 220                 


Leu Pro Asn Arg Ala Glu Glu Lys Ala Gly Gly Glu Ser Val Gln Arg 
225                 230                 235                 240 


Thr Ser Val Gln Ser Phe Glu Glu Glu Thr Gly Asn Pro Leu Asp Met 
                245                 250                 255     


Thr Ser Gly Thr Val Gly Ala Arg Val Asp Arg Ala Asn Ser Cys Gln 
            260                 265                 270         


Ser Asp Ser Ser Gly Phe Leu Glu Glu Pro Leu Glu Pro Leu Pro Leu 
        275                 280                 285             


Gln Met Pro Ser Leu Pro Asn Ser Gln Ser Pro Ala Glu Asn Gly Gly 
    290                 295                 300                 


Arg Lys Pro Arg Asp Gln Ser His Ser Leu Val Ser Ser Gln Asp Cys 
305                 310                 315                 320 


Gln Leu Glu Ser Asp Gly Pro Asp Ser Lys Ser Arg Ala Ser Met Ser 
                325                 330                 335     


Phe Ser Ser Gln Glu Ala Asn Ala Leu Glu Gln Arg Ala Ser Val Ser 
            340                 345                 350         


Val Met Glu Glu Glu Phe Leu Leu Glu Ala Met Glu Gly Pro Pro Glu 
        355                 360                 365             


Leu Tyr Ile Pro Asp Met Ala Cys Ala Lys Thr Thr Thr Arg Gly Glu 
    370                 375                 380                 


Cys Pro Arg Lys Asp Ser His Leu Trp Gln Leu Leu Pro Met Pro His 
385                 390                 395                 400 


Ala Glu Tyr Glu Val Thr Arg Pro Thr Ala Thr Ser Lys Tyr Asp His 
                405                 410                 415     


Pro Leu Gly Phe Met Val Thr His Val Thr Glu Met Gln Asp Ser Phe 
            420                 425                 430         


Val Arg Pro Glu Gly Ala Gly Lys Val Gln Ser His His Asn Glu Ser 
        435                 440                 445             


Gln Arg Ser Pro Gly Asn Asp His Thr Gln Asp Lys Phe Leu His Val 
    450                 455                 460                 


Asp Ser Glu Ala Pro Arg Glu Glu Glu Ser Ser Gly Phe Cys Pro His 
465                 470                 475                 480 


Thr Asn His Ser Leu Leu Val Pro Glu Ser Ser Ser Gln Cys Ile Pro 
                485                 490                 495     


Lys His Ser Glu Ile Thr Pro Tyr Ala Thr Asp Leu Ala Gln Thr Ser 
            500                 505                 510         


Glu Lys Leu Ile Pro His Leu His Lys Leu Pro Gly Asp Pro Ala Gln 
        515                 520                 525             


Val Lys Ser Arg Ser Gly Thr Leu Gly Gln Ile Leu Pro Gly Thr Glu 
    530                 535                 540                 


Ala Glu Met Glu Asn Leu Pro Leu Asn Thr Gly Ser Ser Arg Ser Val 
545                 550                 555                 560 


Met Thr Gln Met Ser Ser Ser Leu Val Ser Ala Ala Gln Arg Ala Val 
                565                 570                 575     


Ala Leu Gly Thr Gly Pro Arg Gly Thr Ser Leu Glu Cys Thr Val Cys 
            580                 585                 590         


Asp Pro Val Thr Ala Thr Glu Thr Arg Leu Gly Thr Lys Ala Arg Gln 
        595                 600                 605             


Leu Asn Asp Ala Ser Ile Gln Thr Ser Ala Leu Ser Asn Lys Thr Leu 
    610                 615                 620                 


Thr His Gly Pro Gln Pro Leu Thr Lys Ser Val Ser Leu Asp Ser Gly 
625                 630                 635                 640 


Phe Ser Ser Ile Cys Pro Met Gly Thr Cys His Ala Ile Pro Ala His 
                645                 650                 655     


Cys Cys Ile Cys Cys His His His Pro His Cys His Gly Glu Arg Gln 
            660                 665                 670         


Ser Pro Gly Pro Glu Pro Ser Val Cys Arg His Cys Leu Cys Ser Leu 
        675                 680                 685             


Thr Gly His Gln Glu Ala Gln Phe Met Thr Thr Leu Lys Ala Leu Gln 
    690                 695                 700                 


Asp Thr Thr Val Arg Glu Leu Cys Ser Cys Thr Val His Glu Met Glu 
705                 710                 715                 720 


Ala Met Lys Thr Ile Cys Gln Ser Phe Arg Glu Tyr Leu Glu Glu Ile 
                725                 730                 735     


Glu Gln His Leu Met Gly Gln Gln Ala Leu Phe Ser Arg Asp Met Ser 
            740                 745                 750         


Glu Glu Glu Arg Glu Glu Ala Glu Gln Leu Gln Thr Leu Arg Glu Ala 
        755                 760                 765             


Leu Arg Gln Gln Val Ala Glu Leu Glu Phe Gln Leu Gly Asp Arg Ala 
    770                 775                 780                 


Gln Gln Ile Arg Glu Gly Ile Leu Leu Gln Leu Glu Val Leu Thr Ala 
785                 790                 795                 800 


Glu Pro Pro Glu His Tyr Ser Asn Leu His Gln Tyr Asn Trp Ile Glu 
                805                 810                 815     


Glu Ser Asn Gly Gln Thr Ser Cys Ser Lys Ile His Pro Gly Met Ala 
            820                 825                 830         


Pro Arg Thr Val Phe Pro Pro Asp Asp Gly Gln Glu Ala Pro Cys Ser 
        835                 840                 845             


Gly Gly Thr Gln Leu Ala Ala Phe Thr Pro Pro Thr Leu Glu Asn Ser 
    850                 855                 860                 


Thr Arg Met Ser Pro Ser Ser Ser Ala Trp Ala Lys Leu Gly Pro Thr 
865                 870                 875                 880 


Pro Leu Ser Asn Cys Pro Val Gly Glu Lys Asp Ala Asp Val Phe Leu 
                885                 890                 895     


<210>  2095
<211>  1044
<212>  PRT
<213>  Homo Sapiens

<400>  2095

Met Met Ala Gln Lys Ser Gln Gly Ser Asp Asn Leu Gln Glu Gly Gln 
1               5                   10                  15      


Glu Lys Ser Lys Arg Glu Ile Leu Lys Cys Thr Lys Ser Ala Trp Ala 
            20                  25                  30          


Pro Leu Asp Glu Trp Leu Pro Pro Asp Pro Glu Glu Glu Ser Gln Ser 
        35                  40                  45              


Leu Thr Ile Pro Met Leu Glu Asp Ser Lys Gln Glu Ser Ile Gln Gln 
    50                  55                  60                  


Trp Leu Asp Ser Gly Phe Phe Val Ser Ala Asn Glu Asn Phe Gln Gln 
65                  70                  75                  80  


Val Ile Asp Arg Thr Val Ser Leu Tyr Glu Gln Gly Met Val Gln Met 
                85                  90                  95      


Thr Val Lys Asp Tyr Met Arg Ser Leu His Gln Phe Ser Glu Thr Pro 
            100                 105                 110         


Ile Leu Ser Arg Gly Thr Ser Phe Asn Ser Cys Tyr Ser Thr Ala Ser 
        115                 120                 125             


Val Pro Gln Ser Ile Pro Glu Trp Leu Glu Phe Trp Glu Ile Asp Pro 
    130                 135                 140                 


Val Glu Ile Leu Leu Asp Leu Gly Phe Gly Ala Asp Glu Pro Asp Ile 
145                 150                 155                 160 


Cys Met Gln Ile Pro Ala Arg Phe Leu Gly Cys Gly Ser Ala Ala Arg 
                165                 170                 175     


Gly Ile Asn Ile Arg Val Phe Leu Glu Ala Gln Lys Gln Arg Met Asp 
            180                 185                 190         


Ile Glu Asn Pro Asn Leu Tyr Gly Arg Phe Arg Gln Leu Glu Ile Leu 
        195                 200                 205             


Asp His Val Thr Asn Ala Phe Ser Ser Leu Leu Ser Asp Val Ser Ile 
    210                 215                 220                 


Leu Pro Asn Arg Ala Glu Glu Lys Ala Gly Gly Glu Ser Val Gln Arg 
225                 230                 235                 240 


Thr Ser Val Ser Ala Ala Lys Glu His Arg Arg Arg Met Gly Lys Leu 
                245                 250                 255     


Leu Arg Arg Ala Ser Lys Gln Asn Ile Arg Arg Asp Cys Asn Pro Glu 
            260                 265                 270         


Val Ser Glu Ser Phe Lys Val Lys Asp Glu Val Phe Val Pro Phe Thr 
        275                 280                 285             


Lys Pro Trp Asp Cys Gly Ala Glu Leu Ala Ala Thr Ser Ile Asn His 
    290                 295                 300                 


Lys Gln Asn His Leu Ser Leu Ser Val Glu His Gln Ser Leu Gln Ala 
305                 310                 315                 320 


Cys Asp Asp Leu Leu Pro Tyr Pro Pro His Gly Leu Leu Ser Lys Gln 
                325                 330                 335     


Trp Pro Cys Ser Ser Met Pro Ala Lys Gln Ala Pro Pro Ser Cys Val 
            340                 345                 350         


Ser Glu Gly Ser Val Lys Gly Arg Thr Gln Lys Glu Asn Leu Phe Gln 
        355                 360                 365             


Thr Asn Lys Leu Lys Ser Leu Ser His Leu Ala Gly Lys Gly Pro Asp 
    370                 375                 380                 


Ser Phe Glu Met Glu Glu Val Gln Ser Phe Glu Glu Glu Thr Gly Asn 
385                 390                 395                 400 


Pro Leu Asp Met Thr Ser Gly Thr Val Gly Ala Arg Val Asp Arg Ala 
                405                 410                 415     


Asn Ser Cys Gln Ser Asp Ser Ser Gly Phe Leu Glu Glu Pro Leu Glu 
            420                 425                 430         


Pro Leu Pro Leu Gln Met Pro Ser Leu Pro Asn Ser Gln Ser Pro Ala 
        435                 440                 445             


Glu Asn Gly Gly Arg Lys Pro Arg Asp Gln Ser His Ser Leu Val Ser 
    450                 455                 460                 


Ser Gln Asp Cys Gln Leu Glu Ser Asp Gly Pro Asp Ser Lys Ser Arg 
465                 470                 475                 480 


Ala Ser Met Ser Phe Ser Ser Gln Glu Ala Asn Ala Leu Glu Gln Arg 
                485                 490                 495     


Ala Ser Val Ser Val Met Glu Glu Glu Phe Leu Leu Glu Ala Met Glu 
            500                 505                 510         


Gly Pro Pro Glu Leu Tyr Ile Pro Asp Met Ala Cys Ala Lys Thr Thr 
        515                 520                 525             


Thr Arg Gly Glu Cys Pro Arg Lys Asp Ser His Leu Trp Gln Leu Leu 
    530                 535                 540                 


Pro Met Pro His Ala Glu Tyr Glu Val Thr Arg Pro Thr Ala Thr Ser 
545                 550                 555                 560 


Lys Tyr Asp His Pro Leu Gly Phe Met Val Thr His Val Thr Glu Met 
                565                 570                 575     


Gln Asp Ser Phe Val Arg Pro Glu Gly Ala Gly Lys Val Gln Ser His 
            580                 585                 590         


His Asn Glu Ser Gln Arg Ser Pro Gly Asn Asp His Thr Gln Asp Lys 
        595                 600                 605             


Phe Leu His Val Asp Ser Glu Ala Pro Arg Glu Glu Glu Ser Ser Gly 
    610                 615                 620                 


Phe Cys Pro His Thr Asn His Ser Leu Leu Val Pro Glu Ser Ser Ser 
625                 630                 635                 640 


Gln Cys Ile Pro Lys His Ser Glu Ile Thr Pro Tyr Ala Thr Asp Leu 
                645                 650                 655     


Ala Gln Thr Ser Glu Lys Leu Ile Pro His Leu His Lys Leu Pro Gly 
            660                 665                 670         


Asp Pro Ala Gln Val Lys Ser Arg Ser Gly Thr Leu Gly Gln Ile Leu 
        675                 680                 685             


Pro Gly Thr Glu Ala Glu Met Glu Asn Leu Pro Leu Asn Thr Gly Ser 
    690                 695                 700                 


Ser Arg Ser Val Met Thr Gln Met Ser Ser Ser Leu Val Ser Ala Ala 
705                 710                 715                 720 


Gln Arg Ala Val Ala Leu Gly Thr Gly Pro Arg Gly Thr Ser Leu Glu 
                725                 730                 735     


Cys Thr Val Cys Asp Pro Val Thr Ala Thr Glu Thr Arg Leu Gly Thr 
            740                 745                 750         


Lys Ala Arg Gln Leu Asn Asp Ala Ser Ile Gln Thr Ser Ala Leu Ser 
        755                 760                 765             


Asn Lys Thr Leu Thr His Gly Pro Gln Pro Leu Thr Lys Ser Val Ser 
    770                 775                 780                 


Leu Asp Ser Gly Phe Ser Ser Ile Cys Pro Met Gly Thr Cys His Ala 
785                 790                 795                 800 


Ile Pro Ala His Cys Cys Ile Cys Cys His His His Pro His Cys His 
                805                 810                 815     


Gly Glu Arg Gln Ser Pro Gly Pro Glu Pro Ser Val Cys Arg His Cys 
            820                 825                 830         


Leu Cys Ser Leu Thr Gly His Gln Glu Ala Gln Phe Met Thr Thr Leu 
        835                 840                 845             


Lys Ala Leu Gln Asp Thr Thr Val Arg Glu Leu Cys Ser Cys Thr Val 
    850                 855                 860                 


His Glu Met Glu Ala Met Lys Thr Ile Cys Gln Ser Phe Arg Glu Tyr 
865                 870                 875                 880 


Leu Glu Glu Ile Glu Gln His Leu Met Gly Gln Gln Ala Leu Phe Ser 
                885                 890                 895     


Arg Asp Met Ser Glu Glu Glu Arg Glu Glu Ala Glu Gln Leu Gln Thr 
            900                 905                 910         


Leu Arg Glu Ala Leu Arg Gln Gln Val Ala Glu Leu Glu Phe Gln Leu 
        915                 920                 925             


Gly Asp Arg Ala Gln Gln Ile Arg Glu Gly Ile Leu Leu Gln Leu Glu 
    930                 935                 940                 


Val Leu Thr Ala Glu Pro Pro Glu His Tyr Ser Asn Leu His Gln Tyr 
945                 950                 955                 960 


Asn Trp Ile Glu Glu Ser Asn Gly Gln Thr Ser Cys Ser Lys Ile His 
                965                 970                 975     


Pro Gly Met Ala Pro Arg Thr Val Phe Pro Pro Asp Asp Gly Gln Glu 
            980                 985                 990         


Ala Pro Cys Ser Gly Gly Thr Gln  Leu Ala Ala Phe Thr  Pro Pro Thr 
        995                 1000                 1005             


Leu Glu  Asn Ser Thr Arg Met  Ser Pro Ser Ser Ser  Ala Trp Ala 
    1010                 1015                 1020             


Lys Leu  Gly Pro Thr Pro Leu  Ser Asn Cys Pro Val  Gly Glu Lys 
    1025                 1030                 1035             


Asp Ala  Asp Val Phe Leu 
    1040                 


<210>  2096
<211>  1062
<212>  PRT
<213>  Homo Sapiens

<400>  2096

Met Pro Thr Thr Ala Ser Cys Lys Thr Ile Ser Leu Leu Lys Leu Leu 
1               5                   10                  15      


Tyr Ser Val Ser Leu Gln Asn Tyr Ser Pro Met Met Ala Gln Lys Ser 
            20                  25                  30          


Gln Gly Ser Asp Asn Leu Gln Glu Gly Gln Glu Lys Ser Lys Arg Glu 
        35                  40                  45              


Ile Leu Lys Cys Thr Lys Ser Ala Trp Ala Pro Leu Asp Glu Trp Leu 
    50                  55                  60                  


Pro Pro Asp Pro Glu Glu Glu Ser Gln Ser Leu Thr Ile Pro Met Leu 
65                  70                  75                  80  


Glu Asp Ser Lys Gln Glu Ser Ile Gln Gln Trp Leu Asp Ser Gly Phe 
                85                  90                  95      


Phe Val Ser Ala Asn Glu Asn Phe Gln Gln Val Ile Asp Arg Thr Val 
            100                 105                 110         


Ser Leu Tyr Glu Gln Gly Met Val Gln Met Thr Val Lys Asp Tyr Met 
        115                 120                 125             


Arg Ser Leu His Gln Phe Ser Glu Thr Pro Ile Leu Ser Arg Gly Thr 
    130                 135                 140                 


Ser Phe Asn Ser Cys Tyr Ser Thr Ala Ser Val Pro Gln Ser Ile Pro 
145                 150                 155                 160 


Glu Trp Leu Glu Phe Trp Glu Ile Asp Pro Val Glu Ile Leu Leu Asp 
                165                 170                 175     


Leu Gly Phe Gly Ala Asp Glu Pro Asp Ile Cys Met Gln Ile Pro Ala 
            180                 185                 190         


Arg Phe Leu Gly Cys Gly Ser Ala Ala Arg Gly Ile Asn Ile Arg Val 
        195                 200                 205             


Phe Leu Glu Ala Gln Lys Gln Arg Met Asp Ile Glu Asn Pro Asn Leu 
    210                 215                 220                 


Tyr Gly Arg Phe Arg Gln Leu Glu Ile Leu Asp His Val Thr Asn Ala 
225                 230                 235                 240 


Phe Ser Ser Leu Leu Ser Asp Val Ser Ile Leu Pro Asn Arg Ala Glu 
                245                 250                 255     


Glu Lys Ala Gly Gly Glu Ser Val Gln Arg Thr Ser Val Ser Ala Ala 
            260                 265                 270         


Lys Glu His Arg Arg Arg Met Gly Lys Leu Leu Arg Arg Ala Ser Lys 
        275                 280                 285             


Gln Asn Ile Arg Arg Asp Cys Asn Pro Glu Val Ser Glu Ser Phe Lys 
    290                 295                 300                 


Val Lys Asp Glu Val Phe Val Pro Phe Thr Lys Pro Trp Asp Cys Gly 
305                 310                 315                 320 


Ala Glu Leu Ala Ala Thr Ser Ile Asn His Lys Gln Asn His Leu Ser 
                325                 330                 335     


Leu Ser Val Glu His Gln Ser Leu Gln Ala Cys Asp Asp Leu Leu Pro 
            340                 345                 350         


Tyr Pro Pro His Gly Leu Leu Ser Lys Gln Trp Pro Cys Ser Ser Met 
        355                 360                 365             


Pro Ala Lys Gln Ala Pro Pro Ser Cys Val Ser Glu Gly Ser Val Lys 
    370                 375                 380                 


Gly Arg Thr Gln Lys Glu Asn Leu Phe Gln Thr Asn Lys Leu Lys Ser 
385                 390                 395                 400 


Leu Ser His Leu Ala Gly Lys Gly Pro Asp Ser Phe Glu Met Glu Glu 
                405                 410                 415     


Val Gln Ser Phe Glu Glu Glu Thr Gly Asn Pro Leu Asp Met Thr Ser 
            420                 425                 430         


Gly Thr Val Gly Ala Arg Val Asp Arg Ala Asn Ser Cys Gln Ser Asp 
        435                 440                 445             


Ser Ser Gly Phe Leu Glu Glu Pro Leu Glu Pro Leu Pro Leu Gln Met 
    450                 455                 460                 


Pro Ser Leu Pro Asn Ser Gln Ser Pro Ala Glu Asn Gly Gly Arg Lys 
465                 470                 475                 480 


Pro Arg Asp Gln Ser His Ser Leu Val Ser Ser Gln Asp Cys Gln Leu 
                485                 490                 495     


Glu Ser Asp Gly Pro Asp Ser Lys Ser Arg Ala Ser Met Ser Phe Ser 
            500                 505                 510         


Ser Gln Glu Ala Asn Ala Leu Glu Gln Arg Ala Ser Val Ser Val Met 
        515                 520                 525             


Glu Glu Glu Phe Leu Leu Glu Ala Met Glu Gly Pro Pro Glu Leu Tyr 
    530                 535                 540                 


Ile Pro Asp Met Ala Cys Ala Lys Thr Thr Thr Arg Gly Glu Cys Pro 
545                 550                 555                 560 


Arg Lys Asp Ser His Leu Trp Gln Leu Leu Pro Met Pro His Ala Glu 
                565                 570                 575     


Tyr Glu Val Thr Arg Pro Thr Ala Thr Ser Lys Tyr Asp His Pro Leu 
            580                 585                 590         


Gly Phe Met Val Thr His Val Thr Glu Met Gln Asp Ser Phe Val Arg 
        595                 600                 605             


Pro Glu Gly Ala Gly Lys Val Gln Ser His His Asn Glu Ser Gln Arg 
    610                 615                 620                 


Ser Pro Gly Asn Asp His Thr Gln Asp Lys Phe Leu His Val Asp Ser 
625                 630                 635                 640 


Glu Ala Pro Arg Glu Glu Glu Ser Ser Gly Phe Cys Pro His Thr Asn 
                645                 650                 655     


His Ser Leu Leu Val Pro Glu Ser Ser Ser Gln Cys Ile Pro Lys His 
            660                 665                 670         


Ser Glu Ile Thr Pro Tyr Ala Thr Asp Leu Ala Gln Thr Ser Glu Lys 
        675                 680                 685             


Leu Ile Pro His Leu His Lys Leu Pro Gly Asp Pro Ala Gln Val Lys 
    690                 695                 700                 


Ser Arg Ser Gly Thr Leu Gly Gln Ile Leu Pro Gly Thr Glu Ala Glu 
705                 710                 715                 720 


Met Glu Asn Leu Pro Leu Asn Thr Gly Ser Ser Arg Ser Val Met Thr 
                725                 730                 735     


Gln Met Ser Ser Ser Leu Val Ser Ala Ala Gln Arg Ala Val Ala Leu 
            740                 745                 750         


Gly Thr Gly Pro Arg Gly Thr Ser Leu Glu Cys Thr Val Cys Asp Pro 
        755                 760                 765             


Val Thr Ala Thr Glu Thr Arg Leu Gly Thr Lys Ala Arg Gln Leu Asn 
    770                 775                 780                 


Asp Ala Ser Ile Gln Thr Ser Ala Leu Ser Asn Lys Thr Leu Thr His 
785                 790                 795                 800 


Gly Pro Gln Pro Leu Thr Lys Ser Val Ser Leu Asp Ser Gly Phe Ser 
                805                 810                 815     


Ser Ile Cys Pro Met Gly Thr Cys His Ala Ile Pro Ala His Cys Cys 
            820                 825                 830         


Ile Cys Cys His His His Pro His Cys His Gly Glu Arg Gln Ser Pro 
        835                 840                 845             


Gly Pro Glu Pro Ser Val Cys Arg His Cys Leu Cys Ser Leu Thr Gly 
    850                 855                 860                 


His Gln Glu Ala Gln Phe Met Thr Thr Leu Lys Ala Leu Gln Asp Thr 
865                 870                 875                 880 


Thr Val Arg Glu Leu Cys Ser Cys Thr Val His Glu Met Glu Ala Met 
                885                 890                 895     


Lys Thr Ile Cys Gln Ser Phe Arg Glu Tyr Leu Glu Glu Ile Glu Gln 
            900                 905                 910         


His Leu Met Gly Gln Gln Ala Leu Phe Ser Arg Asp Met Ser Glu Glu 
        915                 920                 925             


Glu Arg Glu Glu Ala Glu Gln Leu Gln Thr Leu Arg Glu Ala Leu Arg 
    930                 935                 940                 


Gln Gln Val Ala Glu Leu Glu Phe Gln Leu Gly Asp Arg Ala Gln Gln 
945                 950                 955                 960 


Ile Arg Glu Gly Ile Leu Leu Gln Leu Glu Val Leu Thr Ala Glu Pro 
                965                 970                 975     


Pro Glu His Tyr Ser Asn Leu His Gln Tyr Asn Trp Ile Glu Glu Ser 
            980                 985                 990         


Asn Gly Gln Thr Ser Cys Ser Lys  Ile His Pro Gly Met  Ala Pro Arg 
        995                 1000                 1005             


Thr Val  Phe Pro Pro Asp Asp  Gly Gln Glu Ala Pro  Cys Ser Gly 
    1010                 1015                 1020             


Glu Leu  Leu Ser Ala Glu Leu  Asp Pro Phe Phe Phe  Ser Ser Lys 
    1025                 1030                 1035             


Ala Asn  Asn Ser Ala Lys Asp  Glu Lys Ile Lys Ser  Lys Asp Phe 
    1040                 1045                 1050             


Leu Lys  Thr Gln Asp Ser Gly  Leu Leu 
    1055                 1060         


<210>  2097
<211>  1054
<212>  PRT
<213>  Homo Sapiens

<400>  2097

Met Ser Val Ser Leu Gln Asn Tyr Ser Pro Met Met Ala Gln Lys Ser 
1               5                   10                  15      


Gln Gly Ser Asp Asn Leu Gln Glu Gly Gln Glu Lys Ser Lys Arg Glu 
            20                  25                  30          


Ile Leu Lys Cys Thr Lys Ser Ala Trp Ala Pro Leu Asp Glu Trp Leu 
        35                  40                  45              


Pro Pro Asp Pro Glu Glu Glu Ser Gln Ser Leu Thr Ile Pro Met Leu 
    50                  55                  60                  


Glu Asp Ser Lys Gln Glu Ser Ile Gln Gln Trp Leu Asp Ser Gly Phe 
65                  70                  75                  80  


Phe Val Ser Ala Asn Glu Asn Phe Gln Gln Val Ile Asp Arg Thr Val 
                85                  90                  95      


Ser Leu Tyr Glu Gln Gly Met Val Gln Met Thr Val Lys Asp Tyr Met 
            100                 105                 110         


Arg Ser Leu His Gln Phe Ser Glu Thr Pro Ile Leu Ser Arg Gly Thr 
        115                 120                 125             


Ser Phe Asn Ser Cys Tyr Ser Thr Ala Ser Val Pro Gln Ser Ile Pro 
    130                 135                 140                 


Glu Trp Leu Glu Phe Trp Glu Ile Asp Pro Val Glu Ile Leu Leu Asp 
145                 150                 155                 160 


Leu Gly Phe Gly Ala Asp Glu Pro Asp Ile Cys Met Gln Ile Pro Ala 
                165                 170                 175     


Arg Phe Leu Gly Cys Gly Ser Ala Ala Arg Gly Ile Asn Ile Arg Val 
            180                 185                 190         


Phe Leu Glu Ala Gln Lys Gln Arg Met Asp Ile Glu Asn Pro Asn Leu 
        195                 200                 205             


Tyr Gly Arg Phe Arg Gln Leu Glu Ile Leu Asp His Val Thr Asn Ala 
    210                 215                 220                 


Phe Ser Ser Leu Leu Ser Asp Val Ser Ile Leu Pro Asn Arg Ala Glu 
225                 230                 235                 240 


Glu Lys Ala Gly Gly Glu Ser Val Gln Arg Thr Ser Val Ser Ala Ala 
                245                 250                 255     


Lys Glu His Arg Arg Arg Met Gly Lys Leu Leu Arg Arg Ala Ser Lys 
            260                 265                 270         


Gln Asn Ile Arg Arg Asp Cys Asn Pro Glu Val Ser Glu Ser Phe Lys 
        275                 280                 285             


Val Lys Asp Glu Val Phe Val Pro Phe Thr Lys Pro Trp Asp Cys Gly 
    290                 295                 300                 


Ala Glu Leu Ala Ala Thr Ser Ile Asn His Lys Gln Asn His Leu Ser 
305                 310                 315                 320 


Leu Ser Val Glu His Gln Ser Leu Gln Ala Cys Asp Asp Leu Leu Pro 
                325                 330                 335     


Tyr Pro Pro His Gly Leu Leu Ser Lys Gln Trp Pro Cys Ser Ser Met 
            340                 345                 350         


Pro Ala Lys Gln Ala Pro Pro Ser Cys Val Ser Glu Gly Ser Val Lys 
        355                 360                 365             


Gly Arg Thr Gln Lys Glu Asn Leu Phe Gln Thr Asn Lys Leu Lys Ser 
    370                 375                 380                 


Leu Ser His Leu Ala Gly Lys Gly Pro Asp Ser Phe Glu Met Glu Glu 
385                 390                 395                 400 


Val Gln Ser Phe Glu Glu Glu Thr Gly Asn Pro Leu Asp Met Thr Ser 
                405                 410                 415     


Gly Thr Val Gly Ala Arg Val Asp Arg Ala Asn Ser Cys Gln Ser Asp 
            420                 425                 430         


Ser Ser Gly Phe Leu Glu Glu Pro Leu Glu Pro Leu Pro Leu Gln Met 
        435                 440                 445             


Pro Ser Leu Pro Asn Ser Gln Ser Pro Ala Glu Asn Gly Gly Arg Lys 
    450                 455                 460                 


Pro Arg Asp Gln Ser His Ser Leu Val Ser Ser Gln Asp Cys Gln Leu 
465                 470                 475                 480 


Glu Ser Asp Gly Pro Asp Ser Lys Ser Arg Ala Ser Met Ser Phe Ser 
                485                 490                 495     


Ser Gln Glu Ala Asn Ala Leu Glu Gln Arg Ala Ser Val Ser Val Met 
            500                 505                 510         


Glu Glu Glu Phe Leu Leu Glu Ala Met Glu Gly Pro Pro Glu Leu Tyr 
        515                 520                 525             


Ile Pro Asp Met Ala Cys Ala Lys Thr Thr Thr Arg Gly Glu Cys Pro 
    530                 535                 540                 


Arg Lys Asp Ser His Leu Trp Gln Leu Leu Pro Met Pro His Ala Glu 
545                 550                 555                 560 


Tyr Glu Val Thr Arg Pro Thr Ala Thr Ser Lys Tyr Asp His Pro Leu 
                565                 570                 575     


Gly Phe Met Val Thr His Val Thr Glu Met Gln Asp Ser Phe Val Arg 
            580                 585                 590         


Pro Glu Gly Ala Gly Lys Val Gln Ser His His Asn Glu Ser Gln Arg 
        595                 600                 605             


Ser Pro Gly Asn Asp His Thr Gln Asp Lys Phe Leu His Val Asp Ser 
    610                 615                 620                 


Glu Ala Pro Arg Glu Glu Glu Ser Ser Gly Phe Cys Pro His Thr Asn 
625                 630                 635                 640 


His Ser Leu Leu Val Pro Glu Ser Ser Ser Gln Cys Ile Pro Lys His 
                645                 650                 655     


Ser Glu Ile Thr Pro Tyr Ala Thr Asp Leu Ala Gln Thr Ser Glu Lys 
            660                 665                 670         


Leu Ile Pro His Leu His Lys Leu Pro Gly Asp Pro Ala Gln Val Lys 
        675                 680                 685             


Ser Arg Ser Gly Thr Leu Gly Gln Ile Leu Pro Gly Thr Glu Ala Glu 
    690                 695                 700                 


Met Glu Asn Leu Pro Leu Asn Thr Gly Ser Ser Arg Ser Val Met Thr 
705                 710                 715                 720 


Gln Met Ser Ser Ser Leu Val Ser Ala Ala Gln Arg Ala Val Ala Leu 
                725                 730                 735     


Gly Thr Gly Pro Arg Gly Thr Ser Leu Glu Cys Thr Val Cys Asp Pro 
            740                 745                 750         


Val Thr Ala Thr Glu Thr Arg Leu Gly Thr Lys Ala Arg Gln Leu Asn 
        755                 760                 765             


Asp Ala Ser Ile Gln Thr Ser Ala Leu Ser Asn Lys Thr Leu Thr His 
    770                 775                 780                 


Gly Pro Gln Pro Leu Thr Lys Ser Val Ser Leu Asp Ser Gly Phe Ser 
785                 790                 795                 800 


Ser Ile Cys Pro Met Gly Thr Cys His Ala Ile Pro Ala His Cys Cys 
                805                 810                 815     


Ile Cys Cys His His His Pro His Cys His Gly Glu Arg Gln Ser Pro 
            820                 825                 830         


Gly Pro Glu Pro Ser Val Cys Arg His Cys Leu Cys Ser Leu Thr Gly 
        835                 840                 845             


His Gln Glu Ala Gln Phe Met Thr Thr Leu Lys Ala Leu Gln Asp Thr 
    850                 855                 860                 


Thr Val Arg Glu Leu Cys Ser Cys Thr Val His Glu Met Glu Ala Met 
865                 870                 875                 880 


Lys Thr Ile Cys Gln Ser Phe Arg Glu Tyr Leu Glu Glu Ile Glu Gln 
                885                 890                 895     


His Leu Met Gly Gln Gln Ala Leu Phe Ser Arg Asp Met Ser Glu Glu 
            900                 905                 910         


Glu Arg Glu Glu Ala Glu Gln Leu Gln Thr Leu Arg Glu Ala Leu Arg 
        915                 920                 925             


Gln Gln Val Ala Glu Leu Glu Phe Gln Leu Gly Asp Arg Ala Gln Gln 
    930                 935                 940                 


Ile Arg Glu Gly Ile Leu Leu Gln Leu Glu Val Leu Thr Ala Glu Pro 
945                 950                 955                 960 


Pro Glu His Tyr Ser Asn Leu His Gln Tyr Asn Trp Ile Glu Glu Ser 
                965                 970                 975     


Asn Gly Gln Thr Ser Cys Ser Lys Ile His Pro Gly Met Ala Pro Arg 
            980                 985                 990         


Thr Val Phe Pro Pro Asp Asp Gly  Gln Glu Ala Pro Cys  Ser Gly Gly 
        995                 1000                 1005             


Thr Gln  Leu Ala Ala Phe Thr  Pro Pro Thr Leu Glu  Asn Ser Thr 
    1010                 1015                 1020             


Arg Met  Ser Pro Ser Ser Ser  Ala Trp Ala Lys Leu  Gly Pro Thr 
    1025                 1030                 1035             


Pro Leu  Ser Asn Cys Pro Val  Gly Glu Lys Asp Ala  Asp Val Phe 
    1040                 1045                 1050             


Leu 
    


<210>  2098
<211>  952
<212>  PRT
<213>  Homo Sapiens

<400>  2098

Met Val Gln Met Thr Val Lys Asp Tyr Met Arg Ser Leu His Gln Phe 
1               5                   10                  15      


Ser Glu Thr Pro Ile Leu Ser Arg Gly Thr Ser Phe Asn Ser Cys Tyr 
            20                  25                  30          


Ser Thr Ala Ser Val Pro Gln Ser Ile Pro Glu Trp Leu Glu Phe Trp 
        35                  40                  45              


Glu Ile Asp Pro Val Glu Ile Leu Leu Asp Leu Gly Phe Gly Ala Asp 
    50                  55                  60                  


Glu Pro Asp Ile Cys Met Gln Ile Pro Ala Arg Phe Leu Gly Cys Gly 
65                  70                  75                  80  


Ser Ala Ala Arg Gly Ile Asn Ile Arg Val Phe Leu Glu Ala Gln Lys 
                85                  90                  95      


Gln Arg Met Asp Ile Glu Asn Pro Asn Leu Tyr Gly Arg Phe Arg Gln 
            100                 105                 110         


Leu Glu Ile Leu Asp His Val Thr Asn Ala Phe Ser Ser Leu Leu Ser 
        115                 120                 125             


Asp Val Ser Ile Leu Pro Asn Arg Ala Glu Glu Lys Ala Gly Gly Glu 
    130                 135                 140                 


Ser Val Gln Arg Thr Ser Val Ser Ala Ala Lys Glu His Arg Arg Arg 
145                 150                 155                 160 


Met Gly Lys Leu Leu Arg Arg Ala Ser Lys Gln Asn Ile Arg Arg Asp 
                165                 170                 175     


Cys Asn Pro Glu Val Ser Glu Ser Phe Lys Val Lys Asp Glu Val Phe 
            180                 185                 190         


Val Pro Phe Thr Lys Pro Trp Asp Cys Gly Ala Glu Leu Ala Ala Thr 
        195                 200                 205             


Ser Ile Asn His Lys Gln Asn His Leu Ser Leu Ser Val Glu His Gln 
    210                 215                 220                 


Ser Leu Gln Ala Cys Asp Asp Leu Leu Pro Tyr Pro Pro His Gly Leu 
225                 230                 235                 240 


Leu Ser Lys Gln Trp Pro Cys Ser Ser Met Pro Ala Lys Gln Ala Pro 
                245                 250                 255     


Pro Ser Cys Val Ser Glu Gly Ser Val Lys Gly Arg Thr Gln Lys Glu 
            260                 265                 270         


Asn Leu Phe Gln Thr Asn Lys Leu Lys Ser Leu Ser His Leu Ala Gly 
        275                 280                 285             


Lys Gly Pro Asp Ser Phe Glu Met Glu Glu Val Gln Ser Phe Glu Glu 
    290                 295                 300                 


Glu Thr Gly Asn Pro Leu Asp Met Thr Ser Gly Thr Val Gly Ala Arg 
305                 310                 315                 320 


Val Asp Arg Ala Asn Ser Cys Gln Ser Asp Ser Ser Gly Phe Leu Glu 
                325                 330                 335     


Glu Pro Leu Glu Pro Leu Pro Leu Gln Met Pro Ser Leu Pro Asn Ser 
            340                 345                 350         


Gln Ser Pro Ala Glu Asn Gly Gly Arg Lys Pro Arg Asp Gln Ser His 
        355                 360                 365             


Ser Leu Val Ser Ser Gln Asp Cys Gln Leu Glu Ser Asp Gly Pro Asp 
    370                 375                 380                 


Ser Lys Ser Arg Ala Ser Met Ser Phe Ser Ser Gln Glu Ala Asn Ala 
385                 390                 395                 400 


Leu Glu Gln Arg Ala Ser Val Ser Val Met Glu Glu Glu Phe Leu Leu 
                405                 410                 415     


Glu Ala Met Glu Gly Pro Pro Glu Leu Tyr Ile Pro Asp Met Ala Cys 
            420                 425                 430         


Ala Lys Thr Thr Thr Arg Gly Glu Cys Pro Arg Lys Asp Ser His Leu 
        435                 440                 445             


Trp Gln Leu Leu Pro Met Pro His Ala Glu Tyr Glu Val Thr Arg Pro 
    450                 455                 460                 


Thr Ala Thr Ser Lys Tyr Asp His Pro Leu Gly Phe Met Val Thr His 
465                 470                 475                 480 


Val Thr Glu Met Gln Asp Ser Phe Val Arg Pro Glu Gly Ala Gly Lys 
                485                 490                 495     


Val Gln Ser His His Asn Glu Ser Gln Arg Ser Pro Gly Asn Asp His 
            500                 505                 510         


Thr Gln Asp Lys Phe Leu His Val Asp Ser Glu Ala Pro Arg Glu Glu 
        515                 520                 525             


Glu Ser Ser Gly Phe Cys Pro His Thr Asn His Ser Leu Leu Val Pro 
    530                 535                 540                 


Glu Ser Ser Ser Gln Cys Ile Pro Lys His Ser Glu Ile Thr Pro Tyr 
545                 550                 555                 560 


Ala Thr Asp Leu Ala Gln Thr Ser Glu Lys Leu Ile Pro His Leu His 
                565                 570                 575     


Lys Leu Pro Gly Asp Pro Ala Gln Val Lys Ser Arg Ser Gly Thr Leu 
            580                 585                 590         


Gly Gln Ile Leu Pro Gly Thr Glu Ala Glu Met Glu Asn Leu Pro Leu 
        595                 600                 605             


Asn Thr Gly Ser Ser Arg Ser Val Met Thr Gln Met Ser Ser Ser Leu 
    610                 615                 620                 


Val Ser Ala Ala Gln Arg Ala Val Ala Leu Gly Thr Gly Pro Arg Gly 
625                 630                 635                 640 


Thr Ser Leu Glu Cys Thr Val Cys Asp Pro Val Thr Ala Thr Glu Thr 
                645                 650                 655     


Arg Leu Gly Thr Lys Ala Arg Gln Leu Asn Asp Ala Ser Ile Gln Thr 
            660                 665                 670         


Ser Ala Leu Ser Asn Lys Thr Leu Thr His Gly Pro Gln Pro Leu Thr 
        675                 680                 685             


Lys Ser Val Ser Leu Asp Ser Gly Phe Ser Ser Ile Cys Pro Met Gly 
    690                 695                 700                 


Thr Cys His Ala Ile Pro Ala His Cys Cys Ile Cys Cys His His His 
705                 710                 715                 720 


Pro His Cys His Gly Glu Arg Gln Ser Pro Gly Pro Glu Pro Ser Val 
                725                 730                 735     


Cys Arg His Cys Leu Cys Ser Leu Thr Gly His Gln Glu Ala Gln Phe 
            740                 745                 750         


Met Thr Thr Leu Lys Ala Leu Gln Asp Thr Thr Val Arg Glu Leu Cys 
        755                 760                 765             


Ser Cys Thr Val His Glu Met Glu Ala Met Lys Thr Ile Cys Gln Ser 
    770                 775                 780                 


Phe Arg Glu Tyr Leu Glu Glu Ile Glu Gln His Leu Met Gly Gln Gln 
785                 790                 795                 800 


Ala Leu Phe Ser Arg Asp Met Ser Glu Glu Glu Arg Glu Glu Ala Glu 
                805                 810                 815     


Gln Leu Gln Thr Leu Arg Glu Ala Leu Arg Gln Gln Val Ala Glu Leu 
            820                 825                 830         


Glu Phe Gln Leu Gly Asp Arg Ala Gln Gln Ile Arg Glu Gly Ile Leu 
        835                 840                 845             


Leu Gln Leu Glu Val Leu Thr Ala Glu Pro Pro Glu His Tyr Ser Asn 
    850                 855                 860                 


Leu His Gln Tyr Asn Trp Ile Glu Glu Ser Asn Gly Gln Thr Ser Cys 
865                 870                 875                 880 


Ser Lys Ile His Pro Gly Met Ala Pro Arg Thr Val Phe Pro Pro Asp 
                885                 890                 895     


Asp Gly Gln Glu Ala Pro Cys Ser Gly Gly Thr Gln Leu Ala Ala Phe 
            900                 905                 910         


Thr Pro Pro Thr Leu Glu Asn Ser Thr Arg Met Ser Pro Ser Ser Ser 
        915                 920                 925             


Ala Trp Ala Lys Leu Gly Pro Thr Pro Leu Ser Asn Cys Pro Val Gly 
    930                 935                 940                 


Glu Lys Asp Ala Asp Val Phe Leu 
945                 950         


<210>  2099
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  2099

Met Asp Leu Leu Gln Phe Leu Ala Phe Leu Phe Val Leu Leu Leu Ser 
1               5                   10                  15      


Gly Met Gly Ala Thr Gly Thr Leu Arg Thr Ser Leu Asp Pro Ser Leu 
            20                  25                  30          


Glu Ile Tyr Lys Lys Met Phe Glu Val Lys Arg Arg Glu Gln Leu Leu 
        35                  40                  45              


Ala Leu Lys Asn Leu Ala Gln Leu Asn Asp Ile His Gln Gln Tyr Lys 
    50                  55                  60                  


Ile Leu Asp Val Met Leu Lys Gly Leu Phe Lys Phe Ile Pro Ser Thr 
65                  70                  75                  80  


Asp Pro Phe Gln Lys Ala Leu Arg Glu Glu Glu Lys Arg Arg Lys Lys 
                85                  90                  95      


Glu Glu Lys Arg Lys Glu Ile Arg Lys Gly Pro Arg Ile Ser Arg Ser 
            100                 105                 110         


Gln Ser Glu Leu 
        115     


<210>  2100
<211>  229
<212>  PRT
<213>  Homo Sapiens

<400>  2100

Met Asp Leu Leu Gln Phe Leu Ala Phe Leu Phe Val Leu Leu Leu Ser 
1               5                   10                  15      


Gly Met Gly Ala Thr Gly Thr Leu Arg Thr Ser Leu Asp Pro Ser Leu 
            20                  25                  30          


Glu Ile Tyr Lys Lys Met Phe Glu Val Lys Arg Arg Glu Gln Leu Leu 
        35                  40                  45              


Ala Leu Lys Asn Leu Ala Gln Leu Asn Asp Ile His Gln Gln Tyr Lys 
    50                  55                  60                  


Ile Leu Asp Val Met Leu Lys Gly Leu Phe Lys Val Leu Glu Asp Ser 
65                  70                  75                  80  


Arg Thr Val Leu Thr Ala Ala Asp Val Leu Pro Asp Gly Pro Phe Pro 
                85                  90                  95      


Gln Asp Glu Lys Leu Lys Asp Ala Phe Ser His Val Val Glu Asn Thr 
            100                 105                 110         


Ala Phe Phe Gly Asp Val Val Leu Arg Phe Pro Arg Ile Val His Tyr 
        115                 120                 125             


Tyr Phe Asp His Asn Ser Asn Trp Asn Leu Leu Ile Arg Trp Gly Ile 
    130                 135                 140                 


Ser Phe Cys Asn Gln Thr Gly Val Phe Asn Gln Gly Pro His Ser Pro 
145                 150                 155                 160 


Ile Leu Ser Leu Met Ala Gln Glu Leu Gly Ile Ser Glu Lys Asp Ser 
                165                 170                 175     


Asn Phe Gln Asn Pro Phe Lys Ile Asp Arg Thr Glu Phe Ile Pro Ser 
            180                 185                 190         


Thr Asp Pro Phe Gln Lys Ala Leu Arg Glu Glu Glu Lys Arg Arg Lys 
        195                 200                 205             


Lys Glu Glu Lys Arg Lys Glu Ile Arg Lys Gly Pro Arg Ile Ser Arg 
    210                 215                 220                 


Ser Gln Ser Glu Leu 
225                 


<210>  2101
<211>  141
<212>  PRT
<213>  Homo Sapiens

<400>  2101

Met Glu Glu Glu Ala Met Asn Gly Asp Arg Thr Glu Ser Asp Trp Gln 
1               5                   10                  15      


Gly Leu Val Ser Glu Tyr Leu Val Cys Lys Arg Lys Leu Glu Ser Lys 
            20                  25                  30          


Lys Glu Ala Leu Leu Ile Leu Ser Lys Glu Leu Asp Thr Cys Gln Gln 
        35                  40                  45              


Glu Arg Asp Gln Tyr Lys Leu Met Ala Asn Gln Leu Arg Glu Arg His 
    50                  55                  60                  


Gln Ser Leu Lys Lys Lys Tyr Arg Glu Leu Ile Asp Gly Asp Pro Ser 
65                  70                  75                  80  


Leu Pro Pro Glu Lys Arg Lys Gln Ala Asn Leu Ala Gln Leu Leu Arg 
                85                  90                  95      


Asp Ser Gln Asp Arg Asn Lys His Leu Gly Glu Glu Ile Lys Glu Leu 
            100                 105                 110         


Gln Gln Arg Leu Gly Glu Val Gln Gly Asp Asn Lys Gly Arg Leu Arg 
        115                 120                 125             


Ser Lys Lys Lys Met Lys Val Val Pro Leu Leu Arg Arg 
    130                 135                 140     


<210>  2102
<211>  529
<212>  PRT
<213>  Homo Sapiens

<400>  2102

Met Glu Glu Glu Ala Met Asn Gly Asp Arg Thr Glu Ser Asp Trp Gln 
1               5                   10                  15      


Gly Leu Val Ser Glu Tyr Leu Val Cys Lys Arg Lys Leu Glu Ser Lys 
            20                  25                  30          


Lys Glu Ala Leu Leu Ile Leu Ser Lys Glu Leu Asp Thr Cys Gln Gln 
        35                  40                  45              


Glu Arg Asp Gln Tyr Lys Leu Met Ala Asn Gln Leu Arg Glu Arg His 
    50                  55                  60                  


Gln Ser Leu Lys Lys Lys Tyr Arg Glu Leu Ile Asp Gly Asp Pro Ser 
65                  70                  75                  80  


Leu Pro Pro Glu Lys Arg Lys Gln Ala Asn Leu Ala Gln Leu Leu Arg 
                85                  90                  95      


Asp Ser Gln Asp Arg Asn Lys His Leu Gly Glu Glu Ile Lys Glu Leu 
            100                 105                 110         


Gln Gln Arg Leu Gly Glu Val Gln Gly Asp Asn Lys Leu Leu Arg Met 
        115                 120                 125             


Thr Ile Ala Lys Gln Arg Leu Gly Asp Glu Ala Ile Gly Val Arg His 
    130                 135                 140                 


Phe Ala Ala His Glu Arg Glu Asp Leu Val Gln Gln Leu Glu Arg Ala 
145                 150                 155                 160 


Lys Glu Gln Ile Glu Ser Leu Glu His Asp Leu Gln Ala Ser Val Asp 
                165                 170                 175     


Glu Leu Gln Asp Val Lys Glu Glu Arg Ser Ser Tyr Gln Asp Lys Val 
            180                 185                 190         


Glu Arg Leu Asn Gln Glu Leu Asn His Ile Leu Ser Gly His Glu Asn 
        195                 200                 205             


Arg Ile Ile Asp Val Asp Ala Leu Cys Met Glu Asn Arg Tyr Leu Gln 
    210                 215                 220                 


Glu Arg Leu Lys Gln Leu His Glu Glu Val Asn Leu Leu Lys Ser Asn 
225                 230                 235                 240 


Ile Ala Lys Tyr Lys Asn Ala Leu Glu Arg Arg Lys Asn Ser Lys Gly 
                245                 250                 255     


Gln Gly Lys Ser Ser Ser Ser Ala Leu Thr Gly Val Leu Ser Ala Lys 
            260                 265                 270         


Gln Val Gln Asp Leu Leu Ser Glu Asp His Gly Cys Ser Leu Pro Ala 
        275                 280                 285             


Thr Pro Gln Ser Ile Ser Asp Leu Lys Ser Leu Ala Thr Ala Leu Leu 
    290                 295                 300                 


Glu Thr Ile His Glu Lys Asn Met Val Ile Gln His Gln Arg Gln Thr 
305                 310                 315                 320 


Asn Lys Ile Leu Gly Asn Arg Val Ala Glu Leu Glu Lys Lys Leu Arg 
                325                 330                 335     


Thr Leu Glu Val Ser Gly Leu Trp Ser Leu Pro Gly Gly Lys Asp Thr 
            340                 345                 350         


Ile Leu Phe Ser Asp Pro Thr Leu Pro Ser Gly Gln Arg Ser Arg Ser 
        355                 360                 365             


Pro Leu Leu Lys Phe Val Glu Gln Pro Thr Glu Asn Lys Ala Asp Pro 
    370                 375                 380                 


Lys Asp Gly Glu Ala Gln Lys Gln Glu Glu Asp Glu Ser Cys Ala Ala 
385                 390                 395                 400 


Ala Glu Ala Leu Thr Ala Pro Glu Asp Ala Gly Arg Pro Ala Val Asn 
                405                 410                 415     


Ser Pro Ala Asn Gln Ser Arg Gly Asn Gln Cys Lys Leu Phe His Pro 
            420                 425                 430         


Ser Leu Pro Gln Leu Pro Ser Glu Glu Glu Val Asn Ser Leu Gly Arg 
        435                 440                 445             


Glu Ile Ile Lys Leu Thr Lys Glu Gln Ala Ala Ala Glu Leu Glu Glu 
    450                 455                 460                 


Val Arg Arg Glu Ser Pro Ile Glu Gly Gln Arg Ser Glu Thr Gly Pro 
465                 470                 475                 480 


Ala Pro Pro Gly Leu Ala Ile Gln Gly Glu Leu Pro Lys Ser His Leu 
                485                 490                 495     


Asp Ser Phe Glu Ala Ser Arg Pro Ala Ala Lys Ala Ser Thr Pro Glu 
            500                 505                 510         


Asp Gly Lys Gly Ile Pro Glu Gly Gly Gly Met Arg Ser Thr Val Lys 
        515                 520                 525             


Thr 
    


<210>  2103
<211>  540
<212>  PRT
<213>  Homo Sapiens

<400>  2103

Met Glu Glu Glu Ala Met Asn Gly Asp Arg Thr Glu Ser Asp Trp Gln 
1               5                   10                  15      


Gly Leu Val Ser Glu Tyr Leu Val Cys Lys Arg Lys Leu Glu Ser Lys 
            20                  25                  30          


Lys Glu Ala Leu Leu Ile Leu Ser Lys Glu Leu Asp Thr Cys Gln Gln 
        35                  40                  45              


Glu Arg Asp Gln Tyr Lys Leu Met Ala Asn Gln Leu Arg Glu Arg His 
    50                  55                  60                  


Gln Ser Leu Lys Lys Lys Tyr Arg Glu Leu Ile Asp Gly Asp Pro Ser 
65                  70                  75                  80  


Leu Pro Pro Glu Lys Arg Lys Gln Ala Asn Leu Ala Gln Leu Leu Arg 
                85                  90                  95      


Asp Ser Gln Asp Arg Asn Lys His Leu Gly Glu Glu Ile Lys Glu Leu 
            100                 105                 110         


Gln Gln Arg Leu Gly Glu Val Gln Gly Asp Asn Lys Leu Leu Arg Met 
        115                 120                 125             


Thr Ile Ala Lys Gln Arg Leu Gly Asp Glu Ala Ile Gly Val Arg His 
    130                 135                 140                 


Phe Ala Ala His Glu Arg Glu Asp Leu Val Gln Gln Leu Glu Arg Ala 
145                 150                 155                 160 


Lys Glu Gln Ile Glu Ser Leu Glu His Asp Leu Gln Ala Ser Val Asp 
                165                 170                 175     


Glu Leu Gln Asp Val Lys Glu Glu Arg Ser Ser Tyr Gln Asp Lys Val 
            180                 185                 190         


Glu Arg Leu Asn Gln Glu Leu Asn His Ile Leu Ser Gly His Glu Asn 
        195                 200                 205             


Arg Ile Ile Asp Val Asp Ala Leu Cys Met Glu Asn Arg Tyr Leu Gln 
    210                 215                 220                 


Glu Arg Leu Lys Gln Leu His Glu Glu Val Asn Leu Leu Lys Ser Asn 
225                 230                 235                 240 


Ile Ala Lys Tyr Lys Asn Ala Leu Glu Arg Arg Lys Asn Ser Lys Gly 
                245                 250                 255     


Gln Gly Lys Ser Ser Ser Ser Ala Leu Thr Gly Val Leu Ser Ala Lys 
            260                 265                 270         


Gln Val Gln Asp Leu Leu Ser Glu Asp His Gly Cys Ser Leu Pro Ala 
        275                 280                 285             


Thr Pro Gln Ser Ile Ser Asp Leu Lys Ser Leu Ala Thr Ala Leu Leu 
    290                 295                 300                 


Glu Thr Ile His Glu Lys Asn Met Val Ile Gln His Gln Arg Gln Thr 
305                 310                 315                 320 


Asn Lys Ile Leu Gly Asn Arg Val Ala Glu Leu Glu Lys Lys Leu Arg 
                325                 330                 335     


Thr Leu Glu Val Ser Gly Leu Trp Ser Leu Pro Gly Leu Ser Tyr Asn 
            340                 345                 350         


Val Ser Val Gly Phe Gly Arg Gly Lys Asp Thr Ile Leu Phe Ser Asp 
        355                 360                 365             


Pro Thr Leu Pro Ser Gly Gln Arg Ser Arg Ser Pro Leu Leu Lys Phe 
    370                 375                 380                 


Val Glu Gln Pro Thr Glu Asn Lys Ala Asp Pro Lys Asp Gly Glu Ala 
385                 390                 395                 400 


Gln Lys Gln Glu Glu Asp Glu Ser Cys Ala Ala Ala Glu Ala Leu Thr 
                405                 410                 415     


Ala Pro Glu Asp Ala Gly Arg Pro Ala Val Asn Ser Pro Ala Asn Gln 
            420                 425                 430         


Ser Arg Gly Asn Gln Cys Lys Leu Phe His Pro Ser Leu Pro Gln Leu 
        435                 440                 445             


Pro Ser Glu Glu Glu Val Asn Ser Leu Gly Arg Glu Ile Ile Lys Leu 
    450                 455                 460                 


Thr Lys Glu Gln Ala Ala Ala Glu Leu Glu Glu Val Arg Arg Glu Ser 
465                 470                 475                 480 


Pro Ile Glu Gly Gln Arg Ser Glu Thr Gly Pro Ala Pro Pro Gly Leu 
                485                 490                 495     


Ala Ile Gln Gly Glu Leu Pro Lys Ser His Leu Asp Ser Phe Glu Ala 
            500                 505                 510         


Ser Arg Pro Ala Ala Lys Ala Ser Thr Pro Glu Asp Gly Lys Gly Ile 
        515                 520                 525             


Pro Glu Gly Gly Gly Met Arg Ser Thr Val Lys Thr 
    530                 535                 540 


<210>  2104
<211>  529
<212>  PRT
<213>  Homo Sapiens

<400>  2104

Met Val Val Ile Val Val Val Ile Ile Ile Ile Ile Ala Arg Ala Ala 
1               5                   10                  15      


Thr Trp Asp Ser Glu Tyr Leu Val Cys Lys Arg Lys Leu Glu Ser Lys 
            20                  25                  30          


Lys Glu Ala Leu Leu Ile Leu Ser Lys Glu Leu Asp Thr Cys Gln Gln 
        35                  40                  45              


Glu Arg Asp Gln Tyr Lys Leu Met Ala Asn Gln Leu Arg Glu Arg His 
    50                  55                  60                  


Gln Ser Leu Lys Lys Lys Tyr Arg Glu Leu Ile Asp Gly Asp Pro Ser 
65                  70                  75                  80  


Leu Pro Pro Glu Lys Arg Lys Gln Ala Asn Leu Ala Gln Leu Leu Arg 
                85                  90                  95      


Asp Ser Gln Asp Arg Asn Lys His Leu Gly Glu Glu Ile Lys Glu Leu 
            100                 105                 110         


Gln Gln Arg Leu Gly Glu Val Gln Gly Asp Asn Lys Leu Leu Arg Met 
        115                 120                 125             


Thr Ile Ala Lys Gln Arg Leu Gly Asp Glu Ala Ile Gly Val Arg His 
    130                 135                 140                 


Phe Ala Ala His Glu Arg Glu Asp Leu Val Gln Gln Leu Glu Arg Ala 
145                 150                 155                 160 


Lys Glu Gln Ile Glu Ser Leu Glu His Asp Leu Gln Ala Ser Val Asp 
                165                 170                 175     


Glu Leu Gln Asp Val Lys Glu Glu Arg Ser Ser Tyr Gln Asp Lys Val 
            180                 185                 190         


Glu Arg Leu Asn Gln Glu Leu Asn His Ile Leu Ser Gly His Glu Asn 
        195                 200                 205             


Arg Ile Ile Asp Val Asp Ala Leu Cys Met Glu Asn Arg Tyr Leu Gln 
    210                 215                 220                 


Glu Arg Leu Lys Gln Leu His Glu Glu Val Asn Leu Leu Lys Ser Asn 
225                 230                 235                 240 


Ile Ala Lys Tyr Lys Asn Ala Leu Glu Arg Arg Lys Asn Ser Lys Gly 
                245                 250                 255     


Gln Gly Lys Ser Ser Ser Ser Ala Leu Thr Gly Val Leu Ser Ala Lys 
            260                 265                 270         


Gln Val Gln Asp Leu Leu Ser Glu Asp His Gly Cys Ser Leu Pro Ala 
        275                 280                 285             


Thr Pro Gln Ser Ile Ser Asp Leu Lys Ser Leu Ala Thr Ala Leu Leu 
    290                 295                 300                 


Glu Thr Ile His Glu Lys Asn Met Val Ile Gln His Gln Arg Gln Thr 
305                 310                 315                 320 


Asn Lys Ile Leu Gly Asn Arg Val Ala Glu Leu Glu Lys Lys Leu Arg 
                325                 330                 335     


Thr Leu Glu Val Ser Gly Leu Trp Ser Leu Pro Gly Gly Lys Asp Thr 
            340                 345                 350         


Ile Leu Phe Ser Asp Pro Thr Leu Pro Ser Gly Gln Arg Ser Arg Ser 
        355                 360                 365             


Pro Leu Leu Lys Phe Val Glu Gln Pro Thr Glu Asn Lys Ala Asp Pro 
    370                 375                 380                 


Lys Asp Gly Glu Ala Gln Lys Gln Glu Glu Asp Glu Ser Cys Ala Ala 
385                 390                 395                 400 


Ala Glu Ala Leu Thr Ala Pro Glu Asp Ala Gly Arg Pro Ala Val Asn 
                405                 410                 415     


Ser Pro Ala Asn Gln Ser Arg Gly Asn Gln Cys Lys Leu Phe His Pro 
            420                 425                 430         


Ser Leu Pro Gln Leu Pro Ser Glu Glu Glu Val Asn Ser Leu Gly Arg 
        435                 440                 445             


Glu Ile Ile Lys Leu Thr Lys Glu Gln Ala Ala Ala Glu Leu Glu Glu 
    450                 455                 460                 


Val Arg Arg Glu Ser Pro Ile Glu Gly Gln Arg Ser Glu Thr Gly Pro 
465                 470                 475                 480 


Ala Pro Pro Gly Leu Ala Ile Gln Gly Glu Leu Pro Lys Ser His Leu 
                485                 490                 495     


Asp Ser Phe Glu Ala Ser Arg Pro Ala Ala Lys Ala Ser Thr Pro Glu 
            500                 505                 510         


Asp Gly Lys Gly Ile Pro Glu Gly Gly Gly Met Arg Ser Thr Val Lys 
        515                 520                 525             


Thr 
    


<210>  2105
<211>  145
<212>  PRT
<213>  Homo Sapiens

<400>  2105

Met Asp Glu Asn Tyr Asn Leu Leu Pro His Gly Val Asn Phe Gln Asp 
1               5                   10                  15      


Ala Ile Phe Pro Asp Thr Gln Glu Asn Arg Arg Met Phe Ser Ser Leu 
            20                  25                  30          


Phe Gln Phe Ser Asn Cys Ser Gln Gly Gln Gln Leu Ala Thr Phe Ser 
        35                  40                  45              


Ser Asp Trp Glu Ile Gln Glu Asp Ser Arg Leu Met Cys Ser Ser Val 
    50                  55                  60                  


Gln Lys Ala Leu Phe Glu Glu Glu Asp His Val Lys Lys Leu Gln Gln 
65                  70                  75                  80  


Lys Val Ala Thr Leu Glu Lys Arg Asn Arg Gln Leu Arg Glu Arg Val 
                85                  90                  95      


Lys Lys Val Lys Arg Ser Leu Arg Gln Ala Arg Lys Lys Gly Arg His 
            100                 105                 110         


Leu Glu Leu Ala Asn Gln Lys Leu Ser Glu Lys Leu Ala Ala Gly Ala 
        115                 120                 125             


Leu Pro His Ile Asn Ala Arg Gly Pro Val Arg Pro Pro Tyr Leu Arg 
    130                 135                 140                 


Gly 
145 


<210>  2106
<211>  270
<212>  PRT
<213>  Homo Sapiens

<400>  2106

Met Leu Arg Gln Leu Leu Leu Ala Ala Leu Cys Leu Ala Gly Pro Pro 
1               5                   10                  15      


Ala Pro Ala Arg Ala Cys Gln Leu Pro Ser Glu Trp Arg Pro Leu Ser 
            20                  25                  30          


Glu Gly Cys Arg Ala Glu Leu Ala Glu Thr Ile Val Tyr Ala Arg Val 
        35                  40                  45              


Leu Ala Leu His Pro Glu Ala Pro Gly Leu Tyr Asn His Leu Pro Trp 
    50                  55                  60                  


Gln Tyr His Ala Gly Gln Gly Gly Leu Phe Tyr Ser Ala Glu Val Glu 
65                  70                  75                  80  


Met Leu Cys Asp Gln Ala Trp Gly Ser Met Leu Glu Val Pro Ala Gly 
                85                  90                  95      


Ser Arg Leu Asn Leu Thr Gly Leu Gly Tyr Phe Ser Cys His Ser His 
            100                 105                 110         


Thr Val Val Gln Asp Tyr Ser Tyr Phe Phe Phe Leu Arg Met Asp Glu 
        115                 120                 125             


Asn Tyr Asn Leu Leu Pro His Gly Val Asn Phe Gln Asp Ala Ile Phe 
    130                 135                 140                 


Pro Asp Thr Gln Glu Asn Arg Arg Met Phe Ser Ser Leu Phe Gln Phe 
145                 150                 155                 160 


Ser Asn Cys Ser Gln Gly Gln Gln Leu Ala Thr Phe Ser Ser Asp Trp 
                165                 170                 175     


Glu Ile Gln Glu Asp Ser Arg Leu Met Cys Ser Ser Val Gln Lys Ala 
            180                 185                 190         


Leu Phe Glu Glu Glu Asp His Val Lys Lys Leu Gln Gln Lys Val Ala 
        195                 200                 205             


Thr Leu Glu Lys Arg Asn Arg Gln Leu Arg Glu Arg Val Lys Lys Val 
    210                 215                 220                 


Lys Arg Ser Leu Arg Gln Ala Arg Lys Lys Gly Arg His Leu Glu Leu 
225                 230                 235                 240 


Ala Asn Gln Lys Leu Ser Glu Lys Leu Ala Ala Gly Ala Leu Pro His 
                245                 250                 255     


Ile Asn Ala Arg Gly Pro Val Arg Pro Pro Tyr Leu Arg Gly 
            260                 265                 270 


<210>  2107
<211>  212
<212>  PRT
<213>  Homo Sapiens

<400>  2107

Met Ala Leu Arg Ser Met Gly Gln Phe Ser Val Phe Phe Phe Phe Phe 
1               5                   10                  15      


Phe Trp Ala Gln Lys Lys Ile Ala Ser Leu Ser His Ser Gly Phe Leu 
            20                  25                  30          


His Trp Phe Leu Leu Phe Glu Ala Val Ser Ser Asn Gly Val Leu Leu 
        35                  40                  45              


Phe Phe Ser Arg Phe Arg Trp Arg Arg Arg Leu Leu Val Ile Ser Ala 
    50                  55                  60                  


Pro Asn Asp Glu Asp Trp Ala Tyr Ser Gln Gln Leu Ser Ala Leu Ser 
65                  70                  75                  80  


Gly Gln Ala Cys Asn Phe Gly Leu Arg His Ile Thr Ile Leu Lys Leu 
                85                  90                  95      


Leu Gly Val Gly Glu Glu Val Gly Gly Val Leu Glu Leu Phe Pro Ile 
            100                 105                 110         


Asn Gly Ser Ser Val Val Glu Arg Glu Asp Val Pro Ala His Leu Val 
        115                 120                 125             


Lys Asp Ile Arg Asn Tyr Phe Gln Val Ser Pro Glu Tyr Phe Ser Met 
    130                 135                 140                 


Leu Leu Val Gly Lys Asp Gly Asn Val Lys Ser Trp Tyr Pro Ser Pro 
145                 150                 155                 160 


Met Trp Ser Met Val Ile Val Tyr Asp Leu Ile Asp Ser Met Gln Leu 
                165                 170                 175     


Arg Arg Gln Glu Met Ala Ile Gln Gln Ser Leu Gly Met Arg Cys Pro 
            180                 185                 190         


Glu Asp Glu Tyr Ala Gly Tyr Gly Tyr His Ser Tyr His Gln Gly Tyr 
        195                 200                 205             


Gln Asp Gly Tyr 
    210         


<210>  2108
<211>  950
<212>  PRT
<213>  Homo Sapiens

<400>  2108

Met Thr Trp Arg Met Gly Pro Arg Phe Thr Met Leu Leu Ala Met Trp 
1               5                   10                  15      


Leu Val Cys Gly Ser Glu Pro His Pro His Ala Thr Ile Arg Gly Ser 
            20                  25                  30          


His Gly Gly Arg Lys Val Pro Leu Val Ser Pro Asp Ser Ser Arg Pro 
        35                  40                  45              


Ala Arg Phe Leu Arg His Thr Gly Arg Ser Arg Gly Ile Glu Arg Ser 
    50                  55                  60                  


Thr Leu Glu Glu Pro Asn Leu Gln Pro Leu Gln Arg Arg Arg Ser Val 
65                  70                  75                  80  


Pro Val Leu Arg Leu Ala Arg Pro Thr Glu Pro Pro Ala Arg Ser Asp 
                85                  90                  95      


Ile Asn Gly Ala Ala Val Arg Pro Glu Gln Arg Pro Ala Ala Arg Gly 
            100                 105                 110         


Ser Pro Arg Glu Met Ile Arg Asp Glu Gly Ser Ser Ala Arg Ser Arg 
        115                 120                 125             


Met Leu Arg Phe Pro Ser Gly Ser Ser Ser Pro Asn Ile Leu Ala Ser 
    130                 135                 140                 


Phe Ala Gly Lys Asn Arg Val Trp Val Ile Ser Ala Pro His Ala Ser 
145                 150                 155                 160 


Glu Gly Tyr Tyr Arg Leu Met Met Ser Leu Leu Lys Asp Asp Val Tyr 
                165                 170                 175     


Cys Glu Leu Ala Glu Arg His Ile Gln Gln Ile Val Leu Phe His Gln 
            180                 185                 190         


Ala Gly Glu Glu Gly Gly Lys Val Arg Arg Ile Thr Ser Glu Gly Gln 
        195                 200                 205             


Ile Leu Glu Gln Pro Leu Asp Pro Ser Leu Ile Pro Lys Leu Met Ser 
    210                 215                 220                 


Phe Leu Lys Leu Glu Lys Gly Lys Phe Gly Met Val Leu Leu Lys Lys 
225                 230                 235                 240 


Thr Leu Gln Val Glu Glu Arg Tyr Pro Tyr Pro Val Arg Leu Glu Ala 
                245                 250                 255     


Met Tyr Glu Val Ile Asp Gln Gly Pro Ile Arg Arg Ile Glu Lys Ile 
            260                 265                 270         


Arg Gln Lys Gly Phe Val Gln Lys Cys Lys Ala Ser Gly Val Glu Gly 
        275                 280                 285             


Gln Val Val Ala Glu Gly Asn Asp Gly Gly Gly Gly Ala Gly Arg Pro 
    290                 295                 300                 


Ser Leu Gly Ser Glu Lys Lys Lys Glu Asp Pro Arg Arg Ala Gln Val 
305                 310                 315                 320 


Pro Pro Thr Arg Glu Ser Arg Val Lys Val Leu Arg Lys Leu Ala Ala 
                325                 330                 335     


Thr Ala Pro Ala Leu Pro Gln Pro Pro Ser Thr Pro Arg Ala Thr Thr 
            340                 345                 350         


Leu Pro Pro Ala Pro Ala Thr Thr Val Thr Arg Ser Thr Ser Arg Ala 
        355                 360                 365             


Val Thr Val Ala Ala Arg Pro Met Thr Thr Thr Ala Phe Pro Thr Thr 
    370                 375                 380                 


Gln Arg Pro Trp Thr Pro Ser Pro Ser His Arg Pro Pro Thr Thr Thr 
385                 390                 395                 400 


Glu Val Ile Thr Ala Arg Arg Pro Ser Val Ser Glu Asn Leu Tyr Pro 
                405                 410                 415     


Pro Ser Arg Lys Asp Gln His Arg Glu Arg Pro Gln Thr Thr Arg Arg 
            420                 425                 430         


Pro Ser Lys Ala Thr Ser Leu Glu Ser Phe Thr Asn Ala Pro Pro Thr 
        435                 440                 445             


Thr Ile Ser Glu Pro Ser Thr Arg Ala Ala Gly Pro Gly Arg Phe Arg 
    450                 455                 460                 


Asp Asn Arg Met Asp Arg Arg Glu His Gly His Arg Asp Pro Asn Val 
465                 470                 475                 480 


Val Pro Gly Pro Pro Lys Pro Ala Lys Glu Lys Pro Pro Lys Lys Lys 
                485                 490                 495     


Ala Gln Asp Lys Ile Leu Ser Asn Glu Tyr Glu Glu Lys Tyr Asp Leu 
            500                 505                 510         


Ser Arg Pro Thr Ala Ser Gln Leu Glu Asp Glu Leu Gln Val Gly Asn 
        515                 520                 525             


Val Pro Leu Lys Lys Ala Lys Glu Ser Lys Lys His Glu Lys Leu Glu 
    530                 535                 540                 


Lys Pro Glu Lys Glu Lys Lys Lys Lys Met Lys Asn Glu Asn Ala Asp 
545                 550                 555                 560 


Lys Leu Leu Lys Ser Glu Lys Gln Met Lys Lys Ser Glu Lys Lys Ser 
                565                 570                 575     


Lys Gln Glu Lys Glu Lys Ser Lys Lys Lys Lys Gly Gly Lys Thr Glu 
            580                 585                 590         


Gln Asp Gly Tyr Gln Lys Pro Thr Asn Lys His Phe Thr Gln Ser Pro 
        595                 600                 605             


Lys Lys Ser Val Ala Asp Leu Leu Gly Ser Phe Glu Gly Lys Arg Arg 
    610                 615                 620                 


Leu Leu Leu Ile Thr Ala Pro Lys Ala Glu Asn Asn Met Tyr Val Gln 
625                 630                 635                 640 


Gln Arg Asp Glu Tyr Leu Glu Ser Phe Cys Lys Met Ala Thr Arg Lys 
                645                 650                 655     


Ile Ser Val Ile Thr Ile Phe Gly Pro Val Asn Asn Ser Thr Met Lys 
            660                 665                 670         


Ile Asp His Phe Gln Leu Asp Asn Glu Lys Pro Met Arg Val Val Asp 
        675                 680                 685             


Asp Glu Asp Leu Val Asp Gln Arg Leu Ile Ser Glu Leu Arg Lys Glu 
    690                 695                 700                 


Tyr Gly Met Thr Tyr Asn Asp Phe Phe Met Val Leu Thr Asp Val Asp 
705                 710                 715                 720 


Leu Arg Val Lys Gln Tyr Tyr Glu Val Pro Ile Thr Met Lys Ser Val 
                725                 730                 735     


Phe Asp Leu Ile Asp Thr Phe Gln Ser Arg Ile Lys Asp Met Glu Lys 
            740                 745                 750         


Gln Lys Lys Glu Gly Ile Val Cys Lys Glu Asp Lys Lys Gln Ser Leu 
        755                 760                 765             


Glu Asn Phe Leu Ser Arg Phe Arg Trp Arg Arg Arg Leu Leu Val Ile 
    770                 775                 780                 


Ser Ala Pro Asn Asp Glu Asp Trp Ala Tyr Ser Gln Gln Leu Ser Ala 
785                 790                 795                 800 


Leu Ser Gly Gln Ala Cys Asn Phe Gly Leu Arg His Ile Thr Ile Leu 
                805                 810                 815     


Lys Leu Leu Gly Val Gly Glu Glu Val Gly Gly Val Leu Glu Leu Phe 
            820                 825                 830         


Pro Ile Asn Gly Ser Ser Val Val Glu Arg Glu Asp Val Pro Ala His 
        835                 840                 845             


Leu Val Lys Asp Ile Arg Asn Tyr Phe Gln Val Ser Pro Glu Tyr Phe 
    850                 855                 860                 


Ser Met Leu Leu Val Gly Lys Asp Gly Asn Val Lys Ser Trp Tyr Pro 
865                 870                 875                 880 


Ser Pro Met Trp Ser Met Val Ile Val Tyr Asp Leu Ile Asp Ser Met 
                885                 890                 895     


Gln Leu Arg Arg Gln Glu Met Ala Ile Gln Gln Ser Leu Gly Met Arg 
            900                 905                 910         


Cys Pro Glu Asp Glu Tyr Ala Gly Tyr Gly Tyr His Ser Tyr His Gln 
        915                 920                 925             


Gly Tyr Gln Asp Gly Tyr Gln Asp Asp Tyr Arg His His Glu Ser Tyr 
    930                 935                 940                 


His His Gly Tyr Pro Tyr 
945                 950 


<210>  2109
<211>  950
<212>  PRT
<213>  Homo Sapiens

<400>  2109

Met Thr Trp Arg Met Gly Pro Arg Phe Thr Met Leu Leu Ala Met Trp 
1               5                   10                  15      


Leu Val Cys Gly Ser Glu Pro His Pro His Ala Thr Ile Arg Gly Ser 
            20                  25                  30          


His Gly Gly Arg Lys Val Pro Leu Val Ser Pro Asp Ser Ser Arg Pro 
        35                  40                  45              


Ala Arg Phe Leu Arg His Thr Gly Arg Ser Arg Gly Ile Glu Arg Ser 
    50                  55                  60                  


Thr Leu Glu Glu Pro Asn Leu Gln Pro Leu Gln Arg Arg Arg Ser Val 
65                  70                  75                  80  


Pro Val Leu Arg Leu Ala Arg Pro Thr Glu Pro Pro Ala Arg Ser Asp 
                85                  90                  95      


Ile Asn Gly Ala Ala Val Arg Pro Glu Gln Arg Pro Ala Ala Arg Gly 
            100                 105                 110         


Ser Pro Arg Glu Met Ile Arg Asp Glu Gly Ser Ser Ala Arg Ser Arg 
        115                 120                 125             


Met Leu Arg Phe Pro Ser Gly Ser Ser Ser Pro Asn Ile Leu Ala Ser 
    130                 135                 140                 


Phe Ala Gly Lys Asn Arg Val Trp Val Ile Ser Ala Pro His Ala Ser 
145                 150                 155                 160 


Glu Gly Tyr Tyr Arg Leu Met Met Ser Leu Leu Lys Asp Asp Val Tyr 
                165                 170                 175     


Cys Glu Leu Ala Glu Arg His Ile Gln Gln Ile Val Leu Phe His Gln 
            180                 185                 190         


Ala Gly Glu Glu Gly Gly Lys Val Arg Arg Ile Thr Ser Glu Gly Gln 
        195                 200                 205             


Ile Leu Glu Gln Pro Leu Asp Pro Ser Leu Ile Pro Lys Leu Met Ser 
    210                 215                 220                 


Phe Leu Lys Leu Glu Lys Gly Lys Phe Gly Met Val Leu Leu Lys Lys 
225                 230                 235                 240 


Thr Leu Gln Val Glu Glu Arg Tyr Pro Tyr Pro Val Arg Leu Glu Ala 
                245                 250                 255     


Met Tyr Glu Val Ile Asp Gln Gly Pro Ile Arg Arg Ile Glu Lys Ile 
            260                 265                 270         


Arg Gln Lys Gly Phe Val Gln Lys Cys Lys Ala Ser Gly Val Glu Gly 
        275                 280                 285             


Gln Val Val Ala Glu Gly Asn Asp Gly Gly Gly Gly Ala Gly Arg Pro 
    290                 295                 300                 


Ser Leu Gly Ser Glu Lys Lys Lys Glu Asp Pro Arg Arg Ala Gln Val 
305                 310                 315                 320 


Pro Pro Thr Arg Glu Ser Arg Val Lys Val Leu Arg Lys Leu Ala Ala 
                325                 330                 335     


Thr Ala Pro Ala Leu Pro Gln Pro Pro Ser Thr Pro Arg Ala Thr Thr 
            340                 345                 350         


Leu Pro Pro Ala Pro Ala Thr Thr Val Thr Arg Ser Thr Ser Arg Ala 
        355                 360                 365             


Val Thr Val Ala Ala Arg Pro Met Thr Thr Thr Ala Phe Pro Thr Thr 
    370                 375                 380                 


Gln Arg Pro Trp Thr Pro Ser Pro Ser His Arg Pro Pro Thr Thr Thr 
385                 390                 395                 400 


Glu Val Ile Thr Ala Arg Arg Pro Ser Val Ser Glu Asn Leu Tyr Pro 
                405                 410                 415     


Pro Ser Arg Lys Asp Gln His Arg Glu Arg Pro Gln Thr Thr Arg Arg 
            420                 425                 430         


Pro Ser Lys Ala Thr Ser Leu Glu Ser Phe Thr Asn Ala Pro Pro Thr 
        435                 440                 445             


Thr Ile Ser Glu Pro Ser Thr Arg Ala Ala Gly Pro Gly Arg Phe Arg 
    450                 455                 460                 


Asp Asn Arg Met Asp Arg Arg Glu His Gly His Arg Asp Pro Asn Val 
465                 470                 475                 480 


Val Pro Gly Pro Pro Lys Pro Ala Lys Glu Lys Pro Pro Lys Lys Lys 
                485                 490                 495     


Ala Gln Asp Lys Ile Leu Ser Asn Glu Tyr Glu Glu Lys Tyr Asp Leu 
            500                 505                 510         


Ser Arg Pro Thr Ala Ser Gln Leu Glu Asp Glu Leu Gln Val Gly Asn 
        515                 520                 525             


Val Pro Leu Lys Lys Ala Lys Glu Ser Lys Lys His Glu Lys Leu Glu 
    530                 535                 540                 


Lys Pro Glu Lys Glu Lys Lys Lys Lys Met Lys Asn Glu Asn Ala Asp 
545                 550                 555                 560 


Lys Leu Leu Lys Ser Glu Lys Gln Met Lys Lys Ser Glu Lys Lys Ser 
                565                 570                 575     


Lys Gln Glu Lys Glu Lys Ser Lys Lys Lys Lys Gly Gly Lys Thr Glu 
            580                 585                 590         


Gln Asp Gly Tyr Gln Lys Pro Thr Asn Lys His Phe Thr Gln Ser Pro 
        595                 600                 605             


Lys Lys Ser Val Ala Asp Leu Leu Gly Ser Phe Glu Gly Lys Arg Arg 
    610                 615                 620                 


Leu Leu Leu Ile Thr Ala Pro Lys Ala Glu Asn Asn Met Tyr Val Gln 
625                 630                 635                 640 


Gln Arg Asp Glu Tyr Leu Glu Ser Phe Cys Lys Met Ala Thr Arg Lys 
                645                 650                 655     


Ile Ser Val Ile Thr Ile Phe Gly Pro Val Asn Asn Ser Thr Met Lys 
            660                 665                 670         


Ile Asp His Phe Gln Leu Asp Asn Glu Lys Pro Met Arg Val Val Asp 
        675                 680                 685             


Asp Glu Asp Leu Val Asp Gln Arg Leu Ile Ser Glu Leu Arg Lys Glu 
    690                 695                 700                 


Tyr Gly Met Thr Tyr Asn Asp Phe Phe Met Val Leu Thr Asp Val Asp 
705                 710                 715                 720 


Leu Arg Val Lys Gln Tyr Tyr Glu Val Pro Ile Thr Met Lys Ser Val 
                725                 730                 735     


Phe Asp Leu Ile Asp Thr Phe Gln Ser Arg Ile Lys Asp Met Glu Lys 
            740                 745                 750         


Gln Lys Lys Glu Gly Ile Val Cys Lys Glu Asp Lys Lys Gln Ser Leu 
        755                 760                 765             


Glu Asn Phe Leu Ser Arg Phe Arg Trp Arg Arg Arg Leu Leu Val Ile 
    770                 775                 780                 


Ser Ala Pro Asn Asp Glu Asp Trp Ala Tyr Ser Gln Gln Leu Ser Ala 
785                 790                 795                 800 


Leu Ser Gly Gln Ala Cys Asn Phe Gly Leu Arg His Ile Thr Ile Leu 
                805                 810                 815     


Lys Leu Leu Gly Val Gly Glu Glu Val Gly Gly Val Leu Glu Leu Phe 
            820                 825                 830         


Pro Ile Asn Gly Ser Ser Val Val Glu Arg Glu Asp Val Pro Ala His 
        835                 840                 845             


Leu Val Lys Asp Ile Arg Asn Tyr Phe Gln Val Ser Pro Glu Tyr Phe 
    850                 855                 860                 


Ser Met Leu Leu Val Gly Lys Asp Gly Asn Val Lys Ser Trp Tyr Pro 
865                 870                 875                 880 


Ser Pro Met Trp Ser Met Val Ile Val Tyr Asp Leu Ile Asp Ser Met 
                885                 890                 895     


Gln Leu Arg Arg Gln Glu Met Ala Ile Gln Gln Ser Leu Gly Met Arg 
            900                 905                 910         


Cys Pro Glu Asp Glu Tyr Ala Gly Tyr Gly Tyr His Ser Tyr His Gln 
        915                 920                 925             


Gly Tyr Gln Asp Gly Tyr Gln Asp Asp Tyr Arg His His Glu Ser Tyr 
    930                 935                 940                 


His His Gly Tyr Pro Tyr 
945                 950 


<210>  2110
<211>  261
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2110

Xaa Phe Thr Gln Ser Pro Lys Lys Ser Val Ala Asp Leu Leu Gly Ser 
1               5                   10                  15      


Phe Glu Gly Lys Arg Arg Leu Leu Leu Ile Thr Ala Pro Lys Ala Glu 
            20                  25                  30          


Asn Asn Met Tyr Val Gln Gln Arg Asp Glu Tyr Leu Glu Ser Phe Cys 
        35                  40                  45              


Lys Met Ala Thr Arg Lys Ile Ser Val Ile Thr Ile Phe Gly Pro Val 
    50                  55                  60                  


Asn Asn Ser Thr Met Lys Ile Asp His Phe Gln Leu Asp Asn Glu Lys 
65                  70                  75                  80  


Pro Met Arg Val Val Asp Asp Glu Asp Leu Val Asp Gln Arg Leu Ile 
                85                  90                  95      


Ser Glu Leu Arg Lys Glu Tyr Gly Met Thr Tyr Asn Asp Phe Phe Met 
            100                 105                 110         


Val Leu Thr Asp Val Asp Leu Arg Val Lys Gln Tyr Tyr Glu Val Pro 
        115                 120                 125             


Ile Thr Met Lys Ser Val Phe Asp Leu Ile Asp Thr Phe Gln Ser Arg 
    130                 135                 140                 


Ile Lys Asp Met Glu Lys Gln Lys Lys Glu Gly Ile Val Cys Lys Glu 
145                 150                 155                 160 


Asp Lys Lys Gln Ser Leu Glu Asn Phe Leu Ser Arg Phe Arg Trp Arg 
                165                 170                 175     


Arg Arg Leu Leu Val Ile Ser Ala Pro Asn Asp Glu Asp Trp Ala Tyr 
            180                 185                 190         


Ser Gln Gln Leu Ser Ala Leu Ser Gly Gln Ala Cys Asn Phe Gly Ser 
        195                 200                 205             


Ser Val Val Glu Arg Glu Asp Val Pro Ala His Leu Val Lys Asp Ile 
    210                 215                 220                 


Arg Asn Tyr Phe Gln Val Ser Pro Glu Tyr Phe Ser Met Leu Leu Val 
225                 230                 235                 240 


Gly Lys Asp Gly Asn Val Lys Ser Trp Tyr Pro Ser Pro Met Trp Ser 
                245                 250                 255     


Met Val Ile Val Tyr 
            260     


<210>  2111
<211>  553
<212>  PRT
<213>  Homo Sapiens

<400>  2111

Met Ser Lys Ala Ala Gly Gly Ala Ala Ala Ala Ala Ala Ala Ala Glu 
1               5                   10                  15      


Ser Cys Ser Pro Ala Pro Ala Gly Ser Ser Ala Ala Pro Pro Ala Pro 
            20                  25                  30          


Val Glu Asp Leu Ser Lys Val Ser Asp Glu Glu Leu Leu Gln Trp Ser 
        35                  40                  45              


Lys Glu Glu Leu Ile Arg Ser Leu Arg Arg Ala Glu Ala Glu Lys Val 
    50                  55                  60                  


Ser Ala Met Leu Asp His Ser Asn Leu Ile Arg Glu Val Asn Arg Arg 
65                  70                  75                  80  


Leu Gln Leu His Leu Gly Glu Ile Arg Gly Leu Lys Asp Ile Asn Gln 
                85                  90                  95      


Lys Leu Gln Glu Asp Asn Gln Glu Leu Arg Asp Leu Cys Cys Phe Leu 
            100                 105                 110         


Asp Asp Asp Arg Gln Lys Gly Lys Arg Val Ser Arg Glu Trp Gln Arg 
        115                 120                 125             


Leu Gly Arg Tyr Thr Ala Gly Val Met His Lys Glu Val Ala Leu Tyr 
    130                 135                 140                 


Leu Gln Lys Leu Lys Asp Leu Glu Val Lys Gln Glu Glu Val Val Lys 
145                 150                 155                 160 


Glu Asn Met Glu Leu Lys Glu Leu Cys Val Leu Leu Asp Glu Glu Lys 
                165                 170                 175     


Gly Ala Gly Cys Ala Gly Ser Arg Cys Ser Ile Asp Ser Gln Ala Ser 
            180                 185                 190         


Leu Cys Gln Leu Thr Ala Ser Thr Ala Pro Tyr Val Arg Asp Val Gly 
        195                 200                 205             


Asp Gly Ser Ser Thr Ser Ser Thr Gly Ser Thr Asp Ser Pro Asp His 
    210                 215                 220                 


His Lys His His Ala Ser Ser Gly Ser Pro Glu His Leu Gln Lys Pro 
225                 230                 235                 240 


Arg Ser Glu Gly Ser Pro Glu His Ser Lys His Arg Ser Ala Ser Pro 
                245                 250                 255     


Glu His Pro Gln Lys Pro Arg Ala Cys Gly Thr Pro Asp Arg Pro Lys 
            260                 265                 270         


Ala Leu Lys Gly Pro Ser Pro Glu His His Lys Pro Leu Cys Lys Gly 
        275                 280                 285             


Ser Pro Glu Gln Gln Arg His Pro His Pro Gly Ser Ser Pro Glu Thr 
    290                 295                 300                 


Leu Pro Lys His Val Leu Ser Gly Ser Pro Glu His Phe Gln Lys His 
305                 310                 315                 320 


Arg Ser Gly Ser Ser Pro Glu His Ala Arg His Ser Gly Gly Ser Pro 
                325                 330                 335     


Glu His Leu Gln Lys His Ala Leu Gly Gly Ser Leu Glu His Leu Pro 
            340                 345                 350         


Arg Ala Arg Gly Thr Ser Pro Glu His Leu Lys Gln His Tyr Gly Gly 
        355                 360                 365             


Ser Pro Asp His Lys His Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Ser Arg Glu Gly Thr Leu Arg Arg Gln Ala Gln Glu Asp 
385                 390                 395                 400 


Gly Ser Pro His His Arg Asn Val Tyr Ser Gly Met Asn Glu Ser Thr 
                405                 410                 415     


Leu Ser Tyr Val Arg Gln Leu Glu Ala Arg Val Arg Gln Leu Glu Glu 
            420                 425                 430         


Glu Asn Arg Met Leu Pro Gln Ala Ser Gln Asn Arg Arg Gln Pro Pro 
        435                 440                 445             


Thr Arg Asn Ser Ser Asn Met Glu Lys Gly Trp Gly Ser Arg Ala Arg 
    450                 455                 460                 


Arg Val Leu Gln Trp Trp Gln Gly Cys Arg Gly Ile Gly Arg Cys Leu 
465                 470                 475                 480 


Pro Thr Leu Pro Gly Ser Phe Arg Leu Ser Ser Gly Ala Asp Gly Ser 
                485                 490                 495     


Asn Ser Ser Pro Asn Ser Ala Ala Ser Phe Ser Gly His Ala Thr Pro 
            500                 505                 510         


Ser Gln Gln Pro Glu Pro Val Val His Ser Leu Lys Val Val Trp Arg 
        515                 520                 525             


Lys Leu Gly Asp Ala Ala Gly Ser Cys Pro Gly Ile Arg Gln His Leu 
    530                 535                 540                 


Ser Gly Asn Gln Tyr Lys Gly Pro Met 
545                 550             


<210>  2112
<211>  712
<212>  PRT
<213>  Homo Sapiens

<400>  2112

Met Ala Gly Val Ala Ala His Arg Ala His Pro Pro Phe Thr Ala His 
1               5                   10                  15      


Met Lys Asn Arg Gly Leu Arg Glu Glu Leu Glu Lys Ala Val Val Arg 
            20                  25                  30          


Gly Lys Glu Leu Gly Asp Arg Leu Glu His Leu Gln Arg Glu Leu Glu 
        35                  40                  45              


Gln Ala Ala Leu Glu Arg Gln Glu Phe Leu Arg Glu Lys Glu Ser Gln 
    50                  55                  60                  


His Gln Arg Tyr Gln Gly Leu Glu Gln Arg Leu Glu Ala Glu Leu Gln 
65                  70                  75                  80  


Ala Ala Ala Thr Ser Lys Glu Glu Ala Leu Met Glu Leu Lys Thr Arg 
                85                  90                  95      


Ala Leu Gln Leu Glu Glu Glu Leu Phe Gln Leu Arg Gln Gly Pro Ala 
            100                 105                 110         


Gly Leu Gly Pro Lys Lys Arg Ala Glu Pro Gln Leu Val Glu Thr Gln 
        115                 120                 125             


Asn Val Arg Leu Ile Glu Val Glu Arg Ser Asn Ala Met Leu Val Ala 
    130                 135                 140                 


Glu Lys Ala Ala Leu Gln Gly Gln Leu Gln His Leu Glu Gly Gln Leu 
145                 150                 155                 160 


Gly Ser Leu Gln Gly Arg Ala Gln Glu Leu Leu Leu Gln Ser Gln Arg 
                165                 170                 175     


Ala Gln Glu His Ser Ser Arg Leu Gln Ala Glu Lys Ser Val Leu Glu 
            180                 185                 190         


Ile Gln Gly Gln Glu Leu His Arg Lys Leu Glu Val Leu Glu Glu Glu 
        195                 200                 205             


Val Arg Ala Ala Arg Gln Ser Gln Glu Glu Thr Arg Gly Gln Gln Gln 
    210                 215                 220                 


Ala Leu Leu Arg Asp His Lys Ala Leu Ala Gln Leu Gln Arg Arg Gln 
225                 230                 235                 240 


Glu Ala Glu Leu Glu Gly Leu Leu Val Arg His Arg Asp Leu Lys Ala 
                245                 250                 255     


Asn Met Arg Ala Leu Glu Leu Ala His Arg Glu Leu Gln Gly Arg His 
            260                 265                 270         


Glu Gln Leu Gln Ala Gln Arg Ala Ser Val Glu Ala Gln Glu Val Ala 
        275                 280                 285             


Leu Leu Ala Glu Arg Glu Arg Leu Met Gln Asp Gly His Arg Gln Arg 
    290                 295                 300                 


Gly Leu Glu Glu Glu Leu Arg Arg Leu Gln Ser Glu His Asp Arg Ala 
305                 310                 315                 320 


Gln Met Leu Leu Ala Glu Leu Ser Arg Glu Arg Gly Glu Leu Gln Gly 
                325                 330                 335     


Glu Arg Gly Glu Leu Arg Gly Arg Leu Ala Arg Leu Glu Leu Glu Arg 
            340                 345                 350         


Ala Gln Leu Glu Met Gln Ser Gln Gln Leu Arg Glu Ser Asn Gln Gln 
        355                 360                 365             


Leu Asp Leu Ser Ala Cys Arg Leu Thr Thr Gln Cys Glu Leu Leu Thr 
    370                 375                 380                 


Gln Leu Arg Ser Ala Gln Glu Glu Glu Asn Arg Gln Leu Leu Ala Glu 
385                 390                 395                 400 


Val Gln Ala Leu Ser Arg Glu Asn Arg Glu Leu Leu Glu Arg Ser Leu 
                405                 410                 415     


Glu Ser Arg Asp His Leu His Arg Glu Gln Arg Glu Tyr Leu Asp Gln 
            420                 425                 430         


Leu Asn Ala Leu Arg Arg Glu Lys Gln Lys Leu Val Glu Lys Ile Met 
        435                 440                 445             


Asp Gln Tyr Arg Val Leu Glu Pro Val Pro Leu Pro Arg Thr Lys Lys 
    450                 455                 460                 


Gly Ser Trp Leu Ala Asp Lys Gly Pro Leu Pro Arg His Pro Cys Ala 
465                 470                 475                 480 


Gly Pro Arg Ala Pro Ser Ala Cys Gly Met Arg Pro Trp Gln Ala Gly 
                485                 490                 495     


Ser Gly Gly Asn Ser Ala Gln Gly Ser Arg Trp Gly Glu Ala Leu Ser 
            500                 505                 510         


His Ser Ala Leu Gly Thr Pro Leu Gly Asn Asp Ser Asp Ser Ala Ile 
        515                 520                 525             


Gln Ala Pro Trp Gly Arg Pro Ser Pro Thr Ala Lys Asp Leu Val Trp 
    530                 535                 540                 


Asp Gly Arg Thr Pro Leu Arg Pro Cys Arg Asn Thr Lys Gln Met Pro 
545                 550                 555                 560 


Thr Glu Arg Ala Leu Arg Tyr Arg Asn Arg Arg Asn Val Pro Ser Pro 
                565                 570                 575     


His Pro Ser Ala Ser Asp Thr Val Gly Thr Ala Gly Leu Gly Val Gln 
            580                 585                 590         


Pro Ser Arg His Trp Ser Val Ser Gly Gly Pro Arg Gln Pro Lys Ser 
        595                 600                 605             


Ser Gly Ser Gln Gly Pro Gln Gly Glu Ser Leu Asp Lys Glu Ala Trp 
    610                 615                 620                 


Ala Leu Arg Ser Ser Thr Val Ser Ala Gly Ala Arg Arg Trp Ser Trp 
625                 630                 635                 640 


Asp Glu Cys Val Asp Arg Gly Asp Gly Trp Pro Pro Arg Ala Ala Pro 
                645                 650                 655     


Gly Trp Ser Ser Gly Ser Ser Arg Trp Leu Pro Leu Arg Gln Arg Ser 
            660                 665                 670         


Leu Gly Asp Pro Pro Ala Glu Gly Gly Trp Gln Glu Leu Ala Arg Glu 
        675                 680                 685             


Pro Pro Ala Leu Ser Arg Trp Glu Ala Glu Ser Gln Cys Trp Gly Thr 
    690                 695                 700                 


Val Ala Trp Ala Asp Leu Glu Pro 
705                 710         


<210>  2113
<211>  1476
<212>  PRT
<213>  Homo Sapiens

<400>  2113

Met Glu Gly Gly Lys Gly Pro Arg Leu Arg Asp Phe Leu Ser Gly Ser 
1               5                   10                  15      


Leu Ala Thr Trp Ala Leu Gly Leu Ala Gly Leu Val Gly Glu Ala Glu 
            20                  25                  30          


Asp Ser Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu Pro Pro Leu Trp 
        35                  40                  45              


Leu Glu Lys Arg Phe Leu Arg Leu Ser Asp Gly Ala Leu Leu Leu Arg 
    50                  55                  60                  


Val Leu Gly Ile Ile Ala Pro Ser Ser Arg Gly Gly Pro Arg Met Leu 
65                  70                  75                  80  


Arg Gly Leu Asp Gly Pro Ala Ala Trp Arg Val Trp Asn Leu Asn His 
                85                  90                  95      


Leu Trp Gly Arg Leu Arg Asp Phe Tyr Gln Glu Glu Leu Gln Leu Leu 
            100                 105                 110         


Ile Leu Ser Pro Pro Pro Asp Leu Gln Thr Leu Gly Phe Asp Pro Leu 
        115                 120                 125             


Ser Glu Glu Ala Val Glu Gln Leu Glu Gly Val Leu Arg Leu Leu Leu 
    130                 135                 140                 


Gly Ala Ser Val Gln Cys Glu His Arg Glu Leu Phe Ile Arg His Ile 
145                 150                 155                 160 


Gln Gly Leu Ser Leu Glu Val Gln Ser Glu Leu Ala Ala Ala Ile Gln 
                165                 170                 175     


Glu Val Thr Gln Pro Gly Ala Gly Val Val Leu Ala Leu Ser Gly Pro 
            180                 185                 190         


Asp Pro Gly Glu Leu Ala Pro Ala Glu Leu Glu Met Leu Ser Arg Ser 
        195                 200                 205             


Leu Met Gly Thr Leu Ser Lys Leu Ala Arg Glu Arg Asp Leu Gly Ala 
    210                 215                 220                 


Gln Arg Leu Ala Glu Leu Leu Leu Glu Arg Glu Pro Leu Cys Leu Arg 
225                 230                 235                 240 


Pro Glu Ala Pro Ser Arg Ala Pro Ala Glu Gly Pro Ser His His Leu 
                245                 250                 255     


Ala Leu Gln Leu Ala Asn Ala Lys Ala Gln Leu Arg Arg Leu Arg Gln 
            260                 265                 270         


Glu Leu Glu Glu Lys Ala Glu Leu Leu Leu Asp Ser Gln Ala Glu Val 
        275                 280                 285             


Gln Gly Leu Glu Ala Glu Ile Arg Arg Leu Arg Gln Glu Ala Gln Ala 
    290                 295                 300                 


Leu Ser Gly Gln Ala Lys Arg Ala Glu Leu Tyr Arg Glu Glu Ala Glu 
305                 310                 315                 320 


Ala Leu Arg Glu Arg Ala Gly Arg Leu Pro Arg Leu Gln Glu Glu Leu 
                325                 330                 335     


Arg Arg Cys Arg Glu Arg Leu Gln Ala Ala Glu Ala Tyr Lys Ser Gln 
            340                 345                 350         


Leu Glu Glu Glu Arg Val Leu Ser Gly Val Leu Glu Ala Ser Lys Ala 
        355                 360                 365             


Leu Leu Glu Glu Gln Leu Glu Ala Ala Arg Glu Arg Cys Ala Arg Leu 
    370                 375                 380                 


His Glu Thr Gln Arg Glu Asn Leu Leu Leu Arg Thr Arg Leu Gly Glu 
385                 390                 395                 400 


Ala His Ala Glu Leu Asp Ser Leu Arg His Gln Val Asp Gln Leu Ala 
                405                 410                 415     


Glu Glu Asn Val Glu Leu Glu Leu Glu Leu Gln Arg Ser Leu Glu Pro 
            420                 425                 430         


Pro Pro Gly Ser Pro Gly Glu Ala Pro Leu Ala Gly Ala Ala Pro Ser 
        435                 440                 445             


Leu Gln Asp Glu Val Arg Glu Ala Glu Ala Gly Arg Leu Arg Thr Leu 
    450                 455                 460                 


Glu Arg Glu Asn Arg Glu Leu Arg Gly Leu Leu Gln Val Leu Gln Gly 
465                 470                 475                 480 


Gln Pro Gly Gly Gln His Pro Leu Leu Glu Ala Pro Arg Glu Asp Pro 
                485                 490                 495     


Val Leu Pro Val Leu Glu Glu Ala Pro Gln Thr Pro Val Ala Phe Asp 
            500                 505                 510         


His Ser Pro Gln Gly Leu Val Gln Lys Ala Arg Asp Gly Gly Pro Gln 
        515                 520                 525             


Ala Leu Asp Leu Ala Pro Pro Ala Leu Asp Ser Val Leu Glu Ala Ser 
    530                 535                 540                 


Ala Glu Cys Pro Gln Ala Pro Asp Ser Asp Pro Gln Glu Ala Glu Ser 
545                 550                 555                 560 


Pro Leu Gln Ala Ala Ala Met Asp Pro Gln Ala Ser Asp Trp Ser Pro 
                565                 570                 575     


Gln Glu Ser Gly Ser Pro Val Glu Thr Gln Glu Ser Pro Glu Lys Ala 
            580                 585                 590         


Gly Arg Arg Ser Ser Leu Gln Ser Pro Ala Ser Val Ala Pro Pro Gln 
        595                 600                 605             


Gly Pro Gly Thr Lys Ile Gln Ala Pro Gln Leu Leu Gly Gly Glu Thr 
    610                 615                 620                 


Glu Gly Arg Glu Ala Pro Gln Gly Glu Leu Val Pro Glu Ala Trp Gly 
625                 630                 635                 640 


Leu Arg Gln Glu Gly Pro Glu His Lys Pro Gly Pro Ser Glu Pro Ser 
                645                 650                 655     


Ser Val Gln Leu Glu Glu Gln Glu Gly Pro Asn Gln Gly Leu Asp Leu 
            660                 665                 670         


Ala Thr Gly Gln Ala Glu Ala Arg Glu His Asp Gln Arg Leu Glu Gly 
        675                 680                 685             


Thr Val Arg Asp Pro Ala Trp Gln Lys Pro Gln Gln Lys Ser Glu Gly 
    690                 695                 700                 


Ala Leu Glu Val Gln Val Trp Glu Gly Pro Ile Pro Gly Glu Ser Leu 
705                 710                 715                 720 


Ala Ser Gly Val Ala Glu Gln Glu Ala Leu Arg Glu Glu Val Ala Gln 
                725                 730                 735     


Leu Arg Arg Lys Ala Glu Ala Leu Gly Asp Glu Leu Glu Ala Gln Ala 
            740                 745                 750         


Arg Lys Leu Glu Ala Gln Asn Thr Glu Ala Ala Arg Leu Ser Lys Glu 
        755                 760                 765             


Leu Ala Gln Ala Arg Arg Ala Glu Ala Glu Ala His Arg Glu Ala Glu 
    770                 775                 780                 


Ala Gln Ala Trp Glu Gln Ala Arg Leu Arg Glu Ala Val Glu Ala Ala 
785                 790                 795                 800 


Gly Gln Glu Leu Glu Ser Ala Ser Gln Glu Arg Glu Ala Leu Val Glu 
                805                 810                 815     


Ala Leu Ala Ala Ala Gly Arg Glu Arg Arg Gln Trp Glu Arg Glu Gly 
            820                 825                 830         


Ser Arg Leu Arg Ala Gln Ser Glu Ala Ala Glu Glu Arg Met Gln Val 
        835                 840                 845             


Leu Glu Ser Glu Gly Arg Gln His Leu Glu Glu Ala Glu Arg Glu Arg 
    850                 855                 860                 


Arg Glu Lys Glu Ala Leu Gln Ala Glu Leu Glu Lys Ala Val Val Arg 
865                 870                 875                 880 


Gly Lys Glu Leu Gly Asp Arg Leu Glu His Leu Gln Arg Glu Leu Glu 
                885                 890                 895     


Gln Ala Ala Leu Glu Arg Gln Glu Phe Leu Arg Glu Lys Glu Ser Gln 
            900                 905                 910         


His Gln Arg Tyr Gln Gly Leu Glu Gln Arg Leu Glu Ala Glu Leu Gln 
        915                 920                 925             


Ala Ala Ala Thr Ser Lys Glu Glu Ala Leu Met Glu Leu Lys Thr Arg 
    930                 935                 940                 


Ala Leu Gln Leu Glu Glu Glu Leu Phe Gln Leu Arg Gln Gly Pro Ala 
945                 950                 955                 960 


Gly Leu Gly Pro Lys Lys Arg Ala Glu Pro Gln Leu Val Glu Thr Gln 
                965                 970                 975     


Asn Val Arg Leu Ile Glu Val Glu Arg Ser Asn Ala Met Leu Val Ala 
            980                 985                 990         


Glu Lys Ala Ala Leu Gln Gly Gln  Leu Gln His Leu Glu  Gly Gln Leu 
        995                 1000                 1005             


Gly Ser  Leu Gln Gly Arg Ala  Gln Glu Leu Leu Leu  Gln Ser Gln 
    1010                 1015                 1020             


Arg Ala  Gln Glu His Ser Ser  Arg Leu Gln Ala Glu  Lys Ser Val 
    1025                 1030                 1035             


Leu Glu  Ile Gln Gly Gln Glu  Leu His Arg Lys Leu  Glu Val Leu 
    1040                 1045                 1050             


Glu Glu  Glu Val Arg Ala Ala  Arg Gln Ser Gln Glu  Glu Thr Arg 
    1055                 1060                 1065             


Gly Gln  Gln Gln Ala Leu Leu  Arg Asp His Lys Ala  Leu Ala Gln 
    1070                 1075                 1080             


Leu Gln  Arg Arg Gln Glu Ala  Glu Leu Glu Gly Leu  Leu Val Arg 
    1085                 1090                 1095             


His Arg  Asp Leu Lys Ala Asn  Met Arg Ala Leu Glu  Leu Ala His 
    1100                 1105                 1110             


Arg Glu  Leu Gln Gly Arg His  Glu Gln Leu Gln Ala  Gln Arg Ala 
    1115                 1120                 1125             


Ser Val  Glu Ala Gln Glu Val  Ala Leu Leu Ala Glu  Arg Glu Arg 
    1130                 1135                 1140             


Leu Met  Gln Asp Gly His Arg  Gln Arg Gly Leu Glu  Glu Glu Leu 
    1145                 1150                 1155             


Arg Arg  Leu Gln Ser Glu His  Asp Arg Ala Gln Met  Leu Leu Ala 
    1160                 1165                 1170             


Glu Leu  Ser Arg Glu Arg Gly  Glu Leu Gln Gly Glu  Arg Gly Glu 
    1175                 1180                 1185             


Leu Arg  Gly Arg Leu Ala Arg  Leu Glu Leu Glu Arg  Ala Gln Leu 
    1190                 1195                 1200             


Glu Met  Gln Ser Gln Gln Leu  Arg Glu Ser Asn Gln  Gln Leu Asp 
    1205                 1210                 1215             


Leu Ser  Ala Cys Arg Leu Thr  Thr Gln Cys Glu Leu  Leu Thr Gln 
    1220                 1225                 1230             


Leu Arg  Ser Ala Gln Glu Glu  Glu Asn Arg Gln Leu  Leu Ala Glu 
    1235                 1240                 1245             


Val Gln  Ala Leu Ser Arg Glu  Asn Arg Glu Leu Leu  Glu Arg Ser 
    1250                 1255                 1260             


Leu Glu  Ser Arg Asp His Leu  His Arg Glu Gln Arg  Glu Tyr Leu 
    1265                 1270                 1275             


Asp Gln  Leu Asn Ala Leu Arg  Arg Glu Lys Gln Lys  Leu Val Glu 
    1280                 1285                 1290             


Lys Ile  Met Asp Gln Tyr Arg  Val Leu Glu Pro Val  Pro Leu Pro 
    1295                 1300                 1305             


Arg Thr  Lys Lys Gly Ser Trp  Leu Ala Asp Lys Val  Lys Arg Leu 
    1310                 1315                 1320             


Met Arg  Pro Arg Arg Glu Gly  Gly Pro Pro Gly Gly  Leu Arg Leu 
    1325                 1330                 1335             


Gly Ala  Asp Gly Ala Gly Ser  Thr Glu Ser Leu Gly  Gly Pro Pro 
    1340                 1345                 1350             


Glu Thr  Glu Leu Pro Glu Gly  Arg Glu Ala Asp Gly  Thr Gly Ser 
    1355                 1360                 1365             


Pro Ser  Pro Ala Pro Met Arg  Arg Ala Gln Ser Ser  Leu Cys Leu 
    1370                 1375                 1380             


Arg Asp  Glu Thr Leu Ala Gly  Gly Gln Arg Arg Lys  Leu Ser Ser 
    1385                 1390                 1395             


Arg Phe  Pro Val Gly Arg Ser  Ser Glu Ser Phe Ser  Pro Gly Asp 
    1400                 1405                 1410             


Thr Pro  Arg Gln Arg Phe Arg  Gln Arg His Pro Gly  Pro Leu Gly 
    1415                 1420                 1425             


Ala Pro  Val Ser His Ser Lys  Gly Pro Gly Val Gly  Trp Glu Asn 
    1430                 1435                 1440             


Ser Ala  Glu Thr Leu Gln Glu  His Glu Thr Asp Ala  Asn Arg Glu 
    1445                 1450                 1455             


Gly Pro  Glu Val Gln Glu Pro  Glu Lys Arg Pro Leu  Thr Pro Ser 
    1460                 1465                 1470             


Leu Ser  Gln 
    1475     


<210>  2114
<211>  139
<212>  PRT
<213>  Homo Sapiens

<400>  2114

Met Pro Cys Ala Ala Arg Ser Arg Ser Ser Trp Arg Arg Ser Trp Thr 
1               5                   10                  15      


Asn Thr Ala Cys Trp Ser Leu Cys Pro Cys Pro Gly Pro Arg Ser Pro 
            20                  25                  30          


Ser Pro Ala Pro Met Arg Arg Ala Gln Ser Ser Leu Cys Leu Arg Asp 
        35                  40                  45              


Glu Thr Leu Ala Gly Gly Gln Arg Arg Lys Leu Ser Ser Arg Phe Pro 
    50                  55                  60                  


Val Gly Arg Ser Ser Glu Ser Phe Ser Pro Gly Asp Thr Pro Arg Gln 
65                  70                  75                  80  


Arg Phe Arg Gln Arg His Pro Gly Pro Leu Gly Ala Pro Val Ser His 
                85                  90                  95      


Ser Lys Gly Pro Gly Val Gly Trp Glu Asn Ser Ala Glu Thr Leu Gln 
            100                 105                 110         


Glu His Glu Thr Asp Ala Asn Arg Glu Gly Pro Glu Val Gln Glu Pro 
        115                 120                 125             


Glu Lys Arg Pro Leu Thr Pro Ser Leu Ser Gln 
    130                 135                 


<210>  2115
<211>  122
<212>  PRT
<213>  Homo Sapiens

<400>  2115

Glu Asp Glu Glu Glu Glu Lys Glu Glu Arg Lys Arg Gly Pro Met Glu 
1               5                   10                  15      


Thr Phe Glu Asp Leu Trp Gln Arg His Leu Glu Asn Gly Gly Asp Leu 
            20                  25                  30          


Gln Lys Arg Val Ala Glu Lys Ala Ser Asp Lys Glu Thr Ala Gln Phe 
        35                  40                  45              


Gln Ala Glu Glu Lys Gly Val Arg Val Leu Gly Gly Asp Arg Ser Leu 
    50                  55                  60                  


Trp Gln Gly Ala Glu Arg Gly Gly Gly Glu Arg Arg Glu Asp Leu Pro 
65                  70                  75                  80  


His His His His His His His Gln Pro Glu Ala Glu Pro Arg Gln Glu 
                85                  90                  95      


Lys Glu Glu Ala Ser Glu Arg Glu Glu Lys Glu Val Glu Gln Leu Glu 
            100                 105                 110         


His Leu Arg Asp Glu Leu Lys Lys Asp Cys 
        115                 120         


<210>  2116
<211>  266
<212>  PRT
<213>  Homo Sapiens

<400>  2116

Met Pro Pro Arg Gly Pro Ala Ser Glu Leu Leu Leu Leu Arg Leu Leu 
1               5                   10                  15      


Leu Leu Gly Ala Ala Thr Ala Ala Pro Leu Ala Pro Arg Pro Ser Lys 
            20                  25                  30          


Glu Glu Leu Thr Arg Cys Leu Ala Glu Val Val Thr Glu Val Leu Thr 
        35                  40                  45              


Val Gly Gln Val Gln Arg Gly Pro Cys Thr Ala Leu Leu His Lys Glu 
    50                  55                  60                  


Leu Cys Gly Thr Glu Pro His Gly Cys Ala Ser Thr Glu Glu Lys Gly 
65                  70                  75                  80  


Leu Leu Leu Gly Asp Phe Lys Lys Gln Glu Ala Gly Lys Met Arg Ser 
                85                  90                  95      


Ser Gln Glu Val Arg Asp Glu Glu Glu Glu Glu Val Ala Glu Arg Thr 
            100                 105                 110         


His Lys Ser Glu Val Gln Glu Gln Ala Ile Arg Met Gln Gly His Arg 
        115                 120                 125             


Gln Leu His Gln Glu Glu Asp Glu Glu Glu Glu Lys Glu Glu Arg Lys 
    130                 135                 140                 


Arg Gly Pro Met Glu Thr Phe Glu Asp Leu Trp Gln Arg His Leu Glu 
145                 150                 155                 160 


Asn Gly Gly Asp Leu Gln Lys Arg Val Ala Glu Lys Ala Ser Asp Lys 
                165                 170                 175     


Glu Thr Ala Gln Phe Gln Ala Glu Glu Lys Gly Val Arg Val Leu Gly 
            180                 185                 190         


Gly Asp Arg Ser Leu Trp Gln Gly Ala Glu Arg Gly Gly Gly Glu Arg 
        195                 200                 205             


Arg Glu Asp Leu Pro His His His His His His His Gln Pro Glu Ala 
    210                 215                 220                 


Glu Pro Arg Gln Glu Lys Glu Glu Ala Ser Glu Arg Glu Glu Lys Glu 
225                 230                 235                 240 


Val Glu Gln Leu Glu His Leu Arg Asp Glu Leu Lys Lys Val Thr Glu 
                245                 250                 255     


Thr Leu Gly Glu Gln Leu Arg Arg Glu Gly 
            260                 265     


<210>  2117
<211>  115
<212>  PRT
<213>  Homo Sapiens

<400>  2117

Met Asn Ser Gly Val Cys Leu Cys Val Leu Met Ala Val Leu Ala Ala 
1               5                   10                  15      


Gly Ala Leu Thr Gln Pro Val Pro Pro Ala Asp Pro Ala Gly Ser Gly 
            20                  25                  30          


Leu Gln Arg Ala Glu Glu Ala Pro Arg Arg Gln Leu Arg Val Ser Gln 
        35                  40                  45              


Arg Thr Asp Gly Glu Ser Arg Ala His Leu Gly Ala Leu Leu Ala Arg 
    50                  55                  60                  


Tyr Ile Gln Gln Ala Arg Lys Ala Pro Ser Gly Arg Met Ser Ile Val 
65                  70                  75                  80  


Lys Asn Leu Gln Asn Leu Asp Pro Ser His Arg Ile Ser Asp Arg Asp 
                85                  90                  95      


Tyr Met Gly Trp Met Asp Phe Gly Arg Arg Ser Ala Glu Glu Tyr Glu 
            100                 105                 110         


Tyr Pro Ser 
        115 


<210>  2118
<211>  115
<212>  PRT
<213>  Homo Sapiens

<400>  2118

Met Asn Ser Gly Val Cys Leu Cys Val Leu Met Ala Val Leu Ala Ala 
1               5                   10                  15      


Gly Ala Leu Thr Gln Pro Val Pro Pro Ala Asp Pro Ala Gly Ser Gly 
            20                  25                  30          


Leu Gln Arg Ala Glu Glu Ala Pro Arg Arg Gln Leu Arg Val Ser Gln 
        35                  40                  45              


Arg Thr Asp Gly Glu Ser Arg Ala His Leu Gly Ala Leu Leu Ala Arg 
    50                  55                  60                  


Tyr Ile Gln Gln Ala Arg Lys Ala Pro Ser Gly Arg Met Ser Ile Val 
65                  70                  75                  80  


Lys Asn Leu Gln Asn Leu Asp Pro Ser His Arg Ile Ser Asp Arg Asp 
                85                  90                  95      


Tyr Met Gly Trp Met Asp Phe Gly Arg Arg Ser Ala Glu Glu Tyr Glu 
            100                 105                 110         


Tyr Pro Ser 
        115 


<210>  2119
<211>  115
<212>  PRT
<213>  Homo Sapiens

<400>  2119

Met Asn Ser Gly Val Cys Leu Cys Val Leu Met Ala Val Leu Ala Ala 
1               5                   10                  15      


Gly Ala Leu Thr Gln Pro Val Pro Pro Ala Asp Pro Ala Gly Ser Gly 
            20                  25                  30          


Leu Gln Arg Ala Glu Glu Ala Pro Arg Arg Gln Leu Arg Val Ser Gln 
        35                  40                  45              


Arg Thr Asp Gly Glu Ser Arg Ala His Leu Gly Ala Leu Leu Ala Arg 
    50                  55                  60                  


Tyr Ile Gln Gln Ala Arg Lys Ala Pro Ser Gly Arg Met Ser Ile Val 
65                  70                  75                  80  


Lys Asn Leu Gln Asn Leu Asp Pro Ser His Arg Ile Ser Asp Arg Asp 
                85                  90                  95      


Tyr Met Gly Trp Met Asp Phe Gly Arg Arg Ser Ala Glu Glu Tyr Glu 
            100                 105                 110         


Tyr Pro Ser 
        115 


<210>  2120
<211>  96
<212>  PRT
<213>  Homo Sapiens

<400>  2120

Met Gln Ile Ile Thr Thr Ala Leu Val Cys Leu Leu Leu Ala Gly Met 
1               5                   10                  15      


Trp Pro Glu Asp Val Asp Ser Lys Ser Met Gln Val Pro Phe Ser Arg 
            20                  25                  30          


Cys Cys Phe Ser Phe Ala Glu Gln Glu Ile Pro Leu Arg Ala Ile Leu 
        35                  40                  45              


Cys Tyr Arg Asn Thr Ser Ser Ile Cys Ser Asn Glu Gly Leu Ile Phe 
    50                  55                  60                  


Lys Leu Lys Arg Gly Lys Glu Ala Cys Ala Leu Asp Thr Val Gly Trp 
65                  70                  75                  80  


Val Gln Arg His Arg Lys Met Leu Arg His Cys Pro Ser Lys Arg Lys 
                85                  90                  95      


<210>  2121
<211>  97
<212>  PRT
<213>  Homo Sapiens

<400>  2121

Met Lys Val Ser Ala Ala Leu Leu Trp Leu Leu Leu Ile Ala Ala Ala 
1               5                   10                  15      


Phe Ser Pro Gln Gly Leu Ala Gly Pro Ala Ser Val Pro Thr Thr Cys 
            20                  25                  30          


Cys Phe Asn Leu Ala Asn Arg Lys Ile Pro Leu Gln Arg Leu Glu Ser 
        35                  40                  45              


Tyr Arg Arg Ile Thr Ser Gly Lys Cys Pro Gln Lys Ala Val Ile Phe 
    50                  55                  60                  


Lys Thr Lys Leu Ala Lys Asp Ile Cys Ala Asp Pro Lys Lys Lys Trp 
65                  70                  75                  80  


Val Gln Asp Ser Met Lys Tyr Leu Asp Gln Lys Ser Pro Thr Pro Lys 
                85                  90                  95      


Pro 
    


<210>  2122
<211>  98
<212>  PRT
<213>  Homo Sapiens

<400>  2122

Met Lys Val Ser Ala Val Leu Leu Cys Leu Leu Leu Met Thr Ala Ala 
1               5                   10                  15      


Phe Asn Pro Gln Gly Leu Ala Gln Pro Asp Ala Leu Asn Val Pro Ser 
            20                  25                  30          


Thr Cys Cys Phe Thr Phe Ser Ser Lys Lys Ile Ser Leu Gln Arg Leu 
        35                  40                  45              


Lys Ser Tyr Val Ile Thr Thr Ser Arg Cys Pro Gln Lys Ala Val Ile 
    50                  55                  60                  


Phe Arg Thr Lys Leu Gly Lys Glu Ile Cys Ala Asp Pro Lys Glu Lys 
65                  70                  75                  80  


Trp Val Gln Asn Tyr Met Lys His Leu Gly Arg Lys Ala His Thr Leu 
                85                  90                  95      


Lys Thr 
        


<210>  2123
<211>  63
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2123

Xaa Val Pro Ser Thr Cys Cys Phe Thr Phe Ser Ser Lys Lys Ile Ser 
1               5                   10                  15      


Leu Gln Arg Leu Lys Ser Tyr Val Ile Thr Thr Ser Ser Phe Arg Thr 
            20                  25                  30          


Lys Leu Gly Lys Glu Ile Cys Ala Asp Pro Lys Glu Lys Trp Val Gln 
        35                  40                  45              


Asn Tyr Met Lys His Leu Gly Arg Lys Ala His Thr Leu Lys Thr 
    50                  55                  60              


<210>  2124
<211>  109
<212>  PRT
<213>  Homo Sapiens

<400>  2124

Met Lys Ile Ser Val Ala Ala Ile Pro Phe Phe Leu Leu Ile Thr Ile 
1               5                   10                  15      


Ala Leu Gly Thr Lys Thr Glu Ser Ser Ser Gln Thr Gly Gly Lys Pro 
            20                  25                  30          


Lys Val Val Lys Ile Gln Leu Lys Leu Val Gly Gly Pro Tyr His Pro 
        35                  40                  45              


Ser Glu Cys Cys Phe Thr Tyr Thr Thr Tyr Lys Ile Pro Arg Gln Arg 
    50                  55                  60                  


Ile Met Asp Tyr Tyr Glu Thr Asn Ser Gln Cys Ser Lys Pro Gly Ile 
65                  70                  75                  80  


Val Phe Ile Thr Lys Arg Gly His Ser Val Cys Thr Asn Pro Ser Asp 
                85                  90                  95      


Lys Trp Val Gln Asp Tyr Ile Lys Asp Met Lys Glu Asn 
            100                 105                 


<210>  2125
<211>  65
<212>  PRT
<213>  Homo Sapiens

<400>  2125

Met Lys Ile Ser Val Ala Ala Ile Pro Phe Phe Leu Leu Ile Thr Ile 
1               5                   10                  15      


Ala Leu Gly Thr Lys Thr Glu Ser Ser Ser Arg Gly Pro Tyr His Pro 
            20                  25                  30          


Ser Glu Cys Cys Phe Thr Tyr Thr Thr Tyr Lys Ile Pro Arg Gln Arg 
        35                  40                  45              


Ile Met Asp Tyr Tyr Glu Thr Asn Ser Gln Cys Ser Lys Pro Gly Ile 
    50                  55                  60                  


Val 
65  


<210>  2126
<211>  93
<212>  PRT
<213>  Homo Sapiens

<400>  2126

Met Lys Ile Ser Val Ala Ala Ile Pro Phe Phe Leu Leu Ile Thr Ile 
1               5                   10                  15      


Ala Leu Gly Thr Lys Thr Glu Ser Ser Ser Arg Gly Pro Tyr His Pro 
            20                  25                  30          


Ser Glu Cys Cys Phe Thr Tyr Thr Thr Tyr Lys Ile Pro Arg Gln Arg 
        35                  40                  45              


Ile Met Asp Tyr Tyr Glu Thr Asn Ser Gln Cys Ser Lys Pro Gly Ile 
    50                  55                  60                  


Val Phe Ile Thr Lys Arg Gly His Ser Val Cys Thr Asn Pro Ser Asp 
65                  70                  75                  80  


Lys Trp Val Gln Asp Tyr Ile Lys Asp Met Lys Glu Asn 
                85                  90              


<210>  2127
<211>  115
<212>  PRT
<213>  Homo Sapiens

<400>  2127

Met Arg Lys Ala Tyr Ser Pro Leu Gln Val Leu Arg Gly Cys Leu Leu 
1               5                   10                  15      


Leu Pro Ser Leu Leu His Ala Leu Ser Leu Gln Glu Gln Pro Met Val 
            20                  25                  30          


Trp Pro Leu Thr Arg Gly Pro Ser Ser Ala Ser Asp Ala Leu Ser Ser 
        35                  40                  45              


Gly Gly Pro Tyr His Pro Ser Glu Cys Cys Phe Thr Tyr Thr Thr Tyr 
    50                  55                  60                  


Lys Ile Pro Arg Gln Arg Ile Met Asp Tyr Tyr Glu Thr Asn Ser Gln 
65                  70                  75                  80  


Cys Ser Lys Pro Gly Ile Val Phe Ile Thr Lys Arg Gly His Ser Val 
                85                  90                  95      


Cys Thr Asn Pro Ser Asp Lys Trp Val Gln Asp Tyr Ile Lys Asp Met 
            100                 105                 110         


Lys Glu Asn 
        115 


<210>  2128
<211>  113
<212>  PRT
<213>  Homo Sapiens

<400>  2128

Met Lys Val Ser Val Ala Ala Leu Ser Cys Leu Met Leu Val Ala Val 
1               5                   10                  15      


Leu Gly Ser Gln Ala Gln Phe Thr Asn Asp Ala Glu Thr Glu Leu Met 
            20                  25                  30          


Met Ser Lys Leu Pro Leu Glu Asn Pro Val Val Leu Asn Ser Phe His 
        35                  40                  45              


Phe Ala Ala Asp Cys Cys Thr Ser Tyr Ile Ser Gln Ser Ile Pro Cys 
    50                  55                  60                  


Ser Leu Met Lys Ser Tyr Phe Glu Thr Ser Ser Glu Cys Ser Lys Pro 
65                  70                  75                  80  


Gly Val Ile Phe Leu Thr Lys Lys Gly Arg Gln Val Cys Ala Lys Pro 
                85                  90                  95      


Ser Gly Pro Gly Val Gln Asp Cys Met Lys Lys Leu Lys Pro Tyr Ser 
            100                 105                 110         


Ile 
    


<210>  2129
<211>  61
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2129

Xaa Cys Thr Ser Tyr Ile Ser Gln Ser Ile Pro Cys Ser Leu Met Lys 
1               5                   10                  15      


Ser Tyr Phe Glu Thr Ser Ser Glu Cys Ser Lys Pro Gly Val Ile Phe 
            20                  25                  30          


Leu Thr Lys Lys Gly Arg Gln Val Cys Ala Lys Pro Ser Gly Pro Gly 
        35                  40                  45              


Val Gln Asp Cys Met Lys Lys Leu Lys Pro Tyr Ser Ile 
    50                  55                  60      


<210>  2130
<211>  120
<212>  PRT
<213>  Homo Sapiens

<400>  2130

Met Lys Val Ser Glu Ala Ala Leu Ser Leu Leu Val Leu Ile Leu Ile 
1               5                   10                  15      


Ile Thr Ser Ala Ser Arg Ser Gln Pro Lys Val Pro Glu Trp Val Asn 
            20                  25                  30          


Thr Pro Ser Thr Cys Cys Leu Lys Tyr Tyr Glu Lys Val Leu Pro Arg 
        35                  40                  45              


Arg Leu Val Val Gly Tyr Arg Lys Ala Leu Asn Cys His Leu Pro Ala 
    50                  55                  60                  


Ile Ile Phe Val Thr Lys Arg Asn Arg Glu Val Cys Thr Asn Pro Asn 
65                  70                  75                  80  


Asp Asp Trp Val Gln Glu Tyr Ile Lys Asp Pro Asn Leu Pro Leu Leu 
                85                  90                  95      


Pro Thr Arg Asn Leu Ser Thr Val Lys Ile Ile Thr Ala Lys Asn Gly 
            100                 105                 110         


Gln Pro Gln Leu Leu Asn Ser Gln 
        115                 120 


<210>  2131
<211>  53
<212>  PRT
<213>  Homo Sapiens

<400>  2131

Met Lys Val Ser Glu Ala Ala Leu Ser Leu Leu Val Leu Ile Leu Ile 
1               5                   10                  15      


Ile Thr Ser Ala Ser Arg Ser Gln Pro Ser Trp Ser Ala Val Ser Arg 
            20                  25                  30          


Ser Arg Leu Thr Thr Thr Ser Ala Ser Arg Val Gln Val Ile Leu Leu 
        35                  40                  45              


Pro Gln Pro Pro Glu 
    50              


<210>  2132
<211>  95
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2132

Xaa Val Pro Glu Trp Val Asn Thr Pro Ser Thr Cys Cys Leu Lys Tyr 
1               5                   10                  15      


Tyr Glu Lys Val Leu Pro Arg Arg Leu Val Val Gly Tyr Arg Lys Ala 
            20                  25                  30          


Leu Asn Cys His Leu Pro Ala Ile Ile Phe Val Thr Lys Arg Asn Arg 
        35                  40                  45              


Glu Val Cys Thr Asn Pro Asn Asp Asp Trp Val Gln Glu Tyr Ile Lys 
    50                  55                  60                  


Asp Pro Asn Leu Pro Leu Leu Pro Thr Arg Asn Leu Ser Thr Val Lys 
65                  70                  75                  80  


Ile Ile Thr Ala Lys Asn Gly Gln Pro Gln Leu Leu Asn Ser Gln 
                85                  90                  95  


<210>  2133
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  2133

Met Ala Pro Leu Lys Met Leu Ala Leu Val Thr Leu Leu Leu Gly Ala 
1               5                   10                  15      


Ser Leu Gln His Ile His Ala Ala Arg Gly Thr Asn Val Gly Arg Glu 
            20                  25                  30          


Cys Cys Leu Glu Tyr Phe Lys Gly Ala Ile Pro Leu Arg Lys Leu Lys 
        35                  40                  45              


Thr Trp Tyr Gln Thr Ser Glu Asp Cys Ser Arg Asp Ala Ile Val Phe 
    50                  55                  60                  


Val Thr Val Gln Gly Arg Ala Ile Cys Ser Asp Pro Asn Asn Lys Arg 
65                  70                  75                  80  


Val Lys Asn Ala Val Lys Tyr Leu Gln Ser Leu Glu Arg Ser 
                85                  90                  


<210>  2134
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  2134

Met Ala Pro Leu Lys Met Leu Ala Leu Val Thr Leu Leu Leu Gly Ala 
1               5                   10                  15      


Ser Leu Gln His Ile His Ala Ala Arg Gly Thr Asn Val Gly Arg Glu 
            20                  25                  30          


Cys Cys Leu Glu Tyr Phe Lys Gly Ala Ile Pro Leu Arg Lys Leu Lys 
        35                  40                  45              


Thr Trp Tyr Gln Thr Ser Glu Asp Cys Ser Arg Asp Ala Ile Val Phe 
    50                  55                  60                  


Val Thr Val Gln Gly Arg Ala Ile Cys Ser Asp Pro Asn Asn Lys Arg 
65                  70                  75                  80  


Val Lys Asn Ala Val Lys Tyr Leu Gln Ser Leu Glu Arg Ser 
                85                  90                  


<210>  2135
<211>  89
<212>  PRT
<213>  Homo Sapiens

<400>  2135

Met Lys Gly Leu Ala Ala Ala Leu Leu Val Leu Val Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Ser Cys Ala Gln Val Gly Thr Asn Lys Glu Leu Cys Cys Leu 
            20                  25                  30          


Val Tyr Thr Ser Trp Gln Ile Pro Gln Lys Phe Ile Val Asp Tyr Ser 
        35                  40                  45              


Glu Thr Ser Pro Gln Cys Pro Lys Pro Gly Val Ile Leu Leu Thr Lys 
    50                  55                  60                  


Arg Gly Arg Gln Ile Cys Ala Asp Pro Asn Lys Lys Trp Val Gln Lys 
65                  70                  75                  80  


Tyr Ile Ser Asp Leu Lys Leu Asn Ala 
                85                  


<210>  2136
<211>  104
<212>  PRT
<213>  Homo Sapiens

<400>  2136

Met Ala Leu Leu Leu Ala Leu Ser Leu Leu Val Leu Trp Thr Ser Pro 
1               5                   10                  15      


Ala Pro Thr Leu Ser Gly Thr Asn Asp Ala Glu Asp Cys Cys Leu Ser 
            20                  25                  30          


Val Thr Gln Lys Pro Ile Pro Gly Tyr Ile Val Arg Asn Phe His Tyr 
        35                  40                  45              


Leu Leu Ile Lys Asp Gly Cys Arg Val Pro Ala Val Val Phe Thr Thr 
    50                  55                  60                  


Leu Arg Gly Arg Gln Leu Cys Ala Pro Pro Asp Gln Pro Trp Val Glu 
65                  70                  75                  80  


Arg Ile Ile Gln Arg Leu Gln Arg Thr Ser Ala Lys Ala Ser Leu Ala 
                85                  90                  95      


Leu Pro Gly Pro Val Ser Ser Leu 
            100                 


<210>  2137
<211>  98
<212>  PRT
<213>  Homo Sapiens

<400>  2137

Met Ala Leu Leu Leu Ala Leu Ser Leu Leu Val Leu Trp Thr Ser Pro 
1               5                   10                  15      


Ala Pro Thr Leu Ser Gly Thr Asn Asp Ala Glu Asp Cys Cys Leu Ser 
            20                  25                  30          


Val Thr Gln Lys Pro Ile Pro Gly Tyr Ile Val Arg Asn Phe His Tyr 
        35                  40                  45              


Leu Leu Ile Lys Asp Gly Cys Arg Val Pro Ala Val Val Phe Thr Thr 
    50                  55                  60                  


Leu Arg Gly Arg Gln Leu Cys Ala Pro Pro Asp Gln Pro Trp Val Glu 
65                  70                  75                  80  


Arg Ile Ile Gln Arg Leu Gln Arg Thr Ser Ala Lys Met Lys Arg Arg 
                85                  90                  95      


Ser Ser 
        


<210>  2138
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  2138

Met Lys Val Ser Ala Ala Leu Leu Cys Leu Leu Leu Ile Ala Ala Thr 
1               5                   10                  15      


Phe Ile Pro Gln Gly Leu Ala Gln Pro Asp Ala Ile Asn Ala Pro Val 
            20                  25                  30          


Thr Cys Cys Tyr Asn Phe Thr Asn Arg Lys Ile Ser Val Gln Arg Leu 
        35                  40                  45              


Ala Ser Tyr Arg Arg Ile Thr Ser Ser Lys Cys Pro Lys Glu Ala Val 
    50                  55                  60                  


Ile Phe Lys Thr Ile Val Ala Lys Glu Ile Cys Ala Asp Pro Lys Gln 
65                  70                  75                  80  


Lys Trp Val Gln Asp Ser Met Asp His Leu Asp Lys Gln Thr Gln Thr 
                85                  90                  95      


Pro Lys Thr 
            


<210>  2139
<211>  65
<212>  PRT
<213>  Homo Sapiens

<400>  2139

Met Lys Val Ser Ala Ala Leu Leu Cys Leu Leu Leu Ile Ala Ala Thr 
1               5                   10                  15      


Phe Ile Pro Gln Gly Leu Ala Gln Pro Asp Ala Ile Asn Ala Pro Val 
            20                  25                  30          


Thr Cys Cys Tyr Asn Phe Thr Asn Arg Lys Ile Ser Val Gln Arg Leu 
        35                  40                  45              


Ala Ser Tyr Arg Arg Ile Thr Ser Ser Lys Cys Pro Lys Glu Ala Val 
    50                  55                  60                  


Met 
65  


<210>  2140
<211>  25
<212>  PRT
<213>  Homo Sapiens

<400>  2140

Met Cys Cys Thr Lys Ser Leu Leu Leu Ala Ala Leu Met Ser Val Leu 
1               5                   10                  15      


Leu Leu His Leu Cys Gly Glu Ser Glu 
            20                  25  


<210>  2141
<211>  96
<212>  PRT
<213>  Homo Sapiens

<400>  2141

Met Cys Cys Thr Lys Ser Leu Leu Leu Ala Ala Leu Met Ser Val Leu 
1               5                   10                  15      


Leu Leu His Leu Cys Gly Glu Ser Glu Ala Ala Ser Asn Phe Asp Cys 
            20                  25                  30          


Cys Leu Gly Tyr Thr Asp Arg Ile Leu His Pro Lys Phe Ile Val Gly 
        35                  40                  45              


Phe Thr Arg Gln Leu Ala Asn Glu Gly Cys Asp Ile Asn Ala Ile Ile 
    50                  55                  60                  


Phe His Thr Lys Lys Lys Leu Ser Val Cys Ala Asn Pro Lys Gln Thr 
65                  70                  75                  80  


Trp Val Lys Tyr Ile Val Arg Leu Leu Ser Lys Lys Val Lys Asn Met 
                85                  90                  95      


<210>  2142
<211>  95
<212>  PRT
<213>  Homo Sapiens

<400>  2142

Met Cys Cys Thr Lys Ser Leu Leu Leu Ala Ala Leu Met Ser Val Leu 
1               5                   10                  15      


Leu Leu His Leu Cys Gly Glu Ser Glu Ala Ser Asn Phe Asp Cys Cys 
            20                  25                  30          


Leu Gly Tyr Thr Asp Arg Ile Leu His Pro Lys Phe Ile Val Gly Phe 
        35                  40                  45              


Thr Arg Gln Leu Ala Asn Glu Gly Cys Asp Ile Asn Ala Ile Ile Phe 
    50                  55                  60                  


His Thr Lys Lys Lys Leu Ser Val Cys Ala Asn Pro Lys Gln Thr Trp 
65                  70                  75                  80  


Val Lys Tyr Ile Val Arg Leu Leu Ser Lys Lys Val Lys Asn Met 
                85                  90                  95  


<210>  2143
<211>  124
<212>  PRT
<213>  Homo Sapiens

<400>  2143

Met Ala Gln Ser Leu Ala Leu Ser Leu Leu Ile Leu Val Leu Ala Phe 
1               5                   10                  15      


Gly Ile Pro Arg Thr Gln Gly Ser Asp Gly Gly Ala Gln Asp Cys Cys 
            20                  25                  30          


Leu Lys Tyr Ser Gln Arg Lys Ile Pro Ala Lys Val Val Arg Ser Tyr 
        35                  40                  45              


Arg Lys Gln Glu Pro Ser Leu Gly Cys Ser Ile Pro Ala Ile Leu Phe 
    50                  55                  60                  


Leu Pro Arg Lys Arg Ser Gln Ala Glu Leu Cys Ala Asp Pro Lys Glu 
65                  70                  75                  80  


Leu Trp Val Gln Gln Leu Met Gln His Leu Asp Lys Thr Pro Ser Pro 
                85                  90                  95      


Gln Lys Pro Ala Gln Gly Cys Arg Lys Asp Arg Gly Ala Ser Lys Thr 
            100                 105                 110         


Gly Lys Lys Gly Lys Gly Ser Lys Gly Cys Lys Arg 
        115                 120                 


<210>  2144
<211>  134
<212>  PRT
<213>  Homo Sapiens

<400>  2144

Met Ala Gln Ser Leu Ala Leu Ser Leu Leu Ile Leu Val Leu Ala Phe 
1               5                   10                  15      


Gly Ile Pro Arg Thr Gln Gly Ser Asp Gly Gly Ala Gln Asp Cys Cys 
            20                  25                  30          


Leu Lys Tyr Ser Gln Arg Lys Ile Pro Ala Lys Val Val Arg Ser Tyr 
        35                  40                  45              


Arg Lys Gln Glu Pro Ser Leu Gly Cys Ser Ile Pro Ala Ile Leu Phe 
    50                  55                  60                  


Leu Pro Arg Lys Arg Ser Gln Ala Glu Leu Cys Ala Asp Pro Lys Glu 
65                  70                  75                  80  


Leu Trp Val Gln Gln Leu Met Gln His Leu Asp Lys Thr Pro Ser Pro 
                85                  90                  95      


Gln Lys Pro Ala Gln Gly Cys Arg Lys Asp Arg Gly Ala Ser Lys Thr 
            100                 105                 110         


Gly Lys Lys Gly Lys Gly Ser Lys Gly Cys Lys Arg Thr Glu Arg Ser 
        115                 120                 125             


Gln Thr Pro Lys Gly Pro 
    130                 


<210>  2145
<211>  93
<212>  PRT
<213>  Homo Sapiens

<400>  2145

Met Asp Arg Leu Gln Thr Ala Leu Leu Val Val Leu Val Leu Leu Ala 
1               5                   10                  15      


Val Ala Leu Gln Ala Thr Glu Ala Gly Pro Tyr Gly Ala Asn Met Glu 
            20                  25                  30          


Asp Ser Val Cys Cys Arg Asp Tyr Val Arg Tyr Arg Leu Pro Leu Arg 
        35                  40                  45              


Val Val Lys His Phe Tyr Trp Thr Ser Asp Ser Cys Pro Arg Pro Gly 
    50                  55                  60                  


Val Val Leu Leu Thr Phe Arg Asp Lys Glu Ile Cys Ala Asp Pro Arg 
65                  70                  75                  80  


Val Pro Trp Val Lys Met Ile Leu Asn Lys Leu Ser Gln 
                85                  90              


<210>  2146
<211>  13
<212>  PRT
<213>  Homo Sapiens

<400>  2146

Phe Glu Thr Asn Ser Glu Cys Ser Lys Pro Gly Val Met 
1               5                   10              


<210>  2147
<211>  137
<212>  PRT
<213>  Homo Sapiens

<400>  2147

Met Lys Val Ser Val Ala Ala Leu Ser Cys Leu Met Leu Val Thr Ala 
1               5                   10                  15      


Leu Gly Ser Gln Ala Arg Val Thr Lys Asp Ala Glu Thr Glu Phe Met 
            20                  25                  30          


Met Ser Lys Leu Pro Leu Glu Asn Pro Val Leu Leu Asp Met Leu Trp 
        35                  40                  45              


Arg Arg Lys Ile Gly Pro Gln Met Thr Leu Ser His Ala Ala Gly Phe 
    50                  55                  60                  


His Ala Thr Ser Ala Asp Cys Cys Ile Ser Tyr Thr Pro Arg Ser Ile 
65                  70                  75                  80  


Pro Cys Ser Leu Leu Glu Ser Tyr Phe Glu Thr Asn Ser Glu Cys Ser 
                85                  90                  95      


Lys Pro Gly Val Ile Phe Leu Thr Lys Lys Gly Arg Arg Phe Cys Ala 
            100                 105                 110         


Asn Pro Ser Asp Lys Gln Val Gln Val Cys Met Arg Met Leu Lys Leu 
        115                 120                 125             


Asp Thr Arg Ile Lys Thr Arg Lys Asn 
    130                 135         


<210>  2148
<211>  120
<212>  PRT
<213>  Homo Sapiens

<400>  2148

Met Lys Val Ser Val Ala Ala Leu Ser Cys Leu Met Leu Val Thr Ala 
1               5                   10                  15      


Leu Gly Ser Gln Ala Arg Val Thr Lys Asp Ala Glu Thr Glu Phe Met 
            20                  25                  30          


Met Ser Lys Leu Pro Leu Glu Asn Pro Val Leu Leu Asp Arg Phe His 
        35                  40                  45              


Ala Thr Ser Ala Asp Cys Cys Ile Ser Tyr Thr Pro Arg Ser Ile Pro 
    50                  55                  60                  


Cys Ser Leu Leu Glu Ser Tyr Phe Glu Thr Asn Ser Glu Cys Ser Lys 
65                  70                  75                  80  


Pro Gly Val Ile Phe Leu Thr Lys Lys Gly Arg Arg Phe Cys Ala Asn 
                85                  90                  95      


Pro Ser Asp Lys Gln Val Gln Val Cys Met Arg Met Leu Lys Leu Asp 
            100                 105                 110         


Thr Arg Ile Lys Thr Arg Lys Asn 
        115                 120 


<210>  2149
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  2149

Met Ala Gly Leu Met Thr Ile Val Thr Ser Leu Leu Phe Leu Gly Val 
1               5                   10                  15      


Cys Ala His His Ile Ile Pro Thr Gly Ser Val Val Ile Pro Ser Pro 
            20                  25                  30          


Cys Cys Met Phe Phe Val Ser Lys Arg Ile Pro Glu Asn Arg Val Val 
        35                  40                  45              


Ser Tyr Gln Leu Ser Ser Arg Ser Thr Cys Leu Lys Ala Gly Val Ile 
    50                  55                  60                  


Phe Thr Thr Lys Lys Gly Gln Gln Phe Cys Gly Asp Pro Lys Gln Glu 
65                  70                  75                  80  


Trp Val Gln Arg Tyr Met Lys Asn Leu Asp Ala Lys Gln Lys Lys Ala 
                85                  90                  95      


Ser Pro Arg Ala Arg Ala Val Ala Val Lys Gly Pro Val Gln Arg Tyr 
            100                 105                 110         


Pro Gly Asn Gln Thr Thr Cys 
        115                 


<210>  2150
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  2150

Met Ala Gly Leu Met Thr Ile Val Thr Ser Leu Leu Phe Leu Gly Val 
1               5                   10                  15      


Cys Ala His His Ile Ile Pro Thr Gly Ser Val Val Ile Pro Ser Pro 
            20                  25                  30          


Cys Cys Met Phe Phe Val Ser Lys Arg Ile Pro Glu Asn Arg Val Val 
        35                  40                  45              


Ser Tyr Gln Leu Ser Ser Arg Ser Thr Cys Leu Lys Ala Gly Val Ile 
    50                  55                  60                  


Phe Thr Thr Lys Lys Gly Gln Gln Phe Cys Gly Asp Pro Lys Gln Glu 
65                  70                  75                  80  


Trp Val Gln Arg Tyr Met Lys Asn Leu Asp Ala Lys Gln Lys Lys Ala 
                85                  90                  95      


Ser Pro Arg Ala Arg Ala Val Ala Val Lys Gly Pro Val Gln Arg Tyr 
            100                 105                 110         


Pro Gly Asn Gln Thr Thr Cys 
        115                 


<210>  2151
<211>  150
<212>  PRT
<213>  Homo Sapiens

<400>  2151

Met Asn Leu Trp Leu Leu Ala Cys Leu Val Ala Gly Phe Leu Gly Ala 
1               5                   10                  15      


Trp Ala Pro Ala Val His Thr Gln Gly Val Phe Glu Asp Cys Cys Leu 
            20                  25                  30          


Ala Tyr His Tyr Pro Ile Gly Trp Ala Val Leu Arg Arg Ala Trp Thr 
        35                  40                  45              


Tyr Arg Ile Gln Glu Val Ser Gly Ser Cys Asn Leu Pro Ala Ala Ile 
    50                  55                  60                  


Phe Tyr Leu Pro Lys Arg His Arg Lys Val Cys Gly Asn Pro Lys Ser 
65                  70                  75                  80  


Arg Glu Val Gln Arg Ala Met Lys Leu Leu Asp Ala Arg Asn Lys Val 
                85                  90                  95      


Phe Ala Lys Leu His His Asn Thr Gln Thr Phe Gln Ala Gly Pro His 
            100                 105                 110         


Ala Val Lys Lys Leu Ser Ser Gly Asn Ser Lys Leu Ser Ser Ser Lys 
        115                 120                 125             


Phe Ser Asn Pro Ile Ser Ser Ser Lys Arg Asn Val Ser Leu Leu Ile 
    130                 135                 140                 


Ser Ala Asn Ser Gly Lys 
145                 150 


<210>  2152
<211>  150
<212>  PRT
<213>  Homo Sapiens

<400>  2152

Met Asn Leu Trp Leu Leu Ala Cys Leu Val Ala Gly Phe Leu Gly Ala 
1               5                   10                  15      


Trp Ala Pro Ala Val His Thr Gln Gly Val Phe Glu Asp Cys Cys Leu 
            20                  25                  30          


Ala Tyr His Tyr Pro Ile Gly Trp Ala Val Leu Arg Arg Ala Trp Thr 
        35                  40                  45              


Tyr Arg Ile Gln Glu Val Ser Gly Ser Cys Asn Leu Pro Ala Ala Ile 
    50                  55                  60                  


Phe Tyr Leu Pro Lys Arg His Arg Lys Val Cys Gly Asn Pro Lys Ser 
65                  70                  75                  80  


Arg Glu Val Gln Arg Ala Met Lys Leu Leu Asp Ala Arg Asn Lys Val 
                85                  90                  95      


Phe Ala Lys Leu His His Asn Thr Gln Thr Phe Gln Ala Gly Pro His 
            100                 105                 110         


Ala Val Lys Lys Leu Ser Ser Gly Asn Ser Lys Leu Ser Ser Ser Lys 
        115                 120                 125             


Phe Ser Asn Pro Ile Ser Ser Ser Lys Arg Asn Val Ser Leu Leu Ile 
    130                 135                 140                 


Ser Ala Asn Ser Gly Leu 
145                 150 


<210>  2153
<211>  149
<212>  PRT
<213>  Homo Sapiens

<400>  2153

Met Asn Leu Trp Leu Leu Ala Cys Leu Val Ala Gly Phe Leu Gly Ala 
1               5                   10                  15      


Trp Ala Pro Ala Val His Thr Gln Gly Val Phe Glu Asp Cys Cys Leu 
            20                  25                  30          


Ala Tyr His Tyr Pro Ile Gly Trp Ala Val Leu Arg Arg Ala Trp Thr 
        35                  40                  45              


Tyr Arg Ile Gln Glu Val Ser Gly Ser Cys Asn Leu Pro Ala Ala Ile 
    50                  55                  60                  


Phe Tyr Leu Pro Lys Arg His Arg Lys Val Cys Gly Asn Pro Lys Ser 
65                  70                  75                  80  


Arg Glu Val Gln Arg Ala Met Lys Leu Leu Asp Ala Arg Asn Lys Val 
                85                  90                  95      


Phe Ala Lys Leu His His Asn Thr Gln Thr Phe Gln Gly Pro His Ala 
            100                 105                 110         


Val Lys Lys Leu Ser Ser Gly Asn Ser Lys Leu Ser Ser Ser Lys Phe 
        115                 120                 125             


Ser Asn Pro Ile Ser Ser Ser Lys Arg Asn Val Ser Leu Leu Ile Ser 
    130                 135                 140                 


Ala Asn Ser Gly Leu 
145                 


<210>  2154
<211>  84
<212>  PRT
<213>  Homo Sapiens

<400>  2154

Met Asn Leu Trp Leu Leu Ala Cys Leu Val Ala Gly Phe Leu Gly Ala 
1               5                   10                  15      


Trp Ala Pro Ala Val His Thr Gln Gly Val Phe Glu Asp Cys Cys Leu 
            20                  25                  30          


Ala Tyr His Tyr Pro Ile Gly Trp Ala Val Leu Arg Arg Ala Trp Thr 
        35                  40                  45              


Tyr Arg Ile Gln Glu Val Ser Gly Ser Cys Asn Leu Pro Ala Ala Ile 
    50                  55                  60                  


Arg Pro Ser Cys Cys Lys Glu Val Glu Phe Trp Lys Leu Gln Val Ile 
65                  70                  75                  80  


Ile Val Gln Val 
                


<210>  2155
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  2155

Met Met Gly Leu Ser Leu Ala Ser Ala Val Leu Leu Ala Ser Leu Leu 
1               5                   10                  15      


Ser Leu His Leu Gly Thr Ala Thr Arg Gly Ser Asp Ile Ser Lys Thr 
            20                  25                  30          


Cys Cys Phe Gln Tyr Ser His Lys Pro Leu Pro Trp Thr Trp Val Arg 
        35                  40                  45              


Ser Tyr Glu Phe Thr Ser Asn Ser Cys Ser Gln Arg Ala Val Ile Phe 
    50                  55                  60                  


Thr Thr Lys Arg Gly Lys Lys Val Cys Thr His Pro Arg Lys Lys Trp 
65                  70                  75                  80  


Val Gln Lys Tyr Ile Ser Leu Leu Lys Thr Pro Lys Gln Leu 
                85                  90                  


<210>  2156
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  2156

Met Met Gly Leu Ser Leu Ala Ser Ala Val Leu Leu Ala Ser Leu Leu 
1               5                   10                  15      


Ser Leu His Leu Gly Thr Ala Thr Arg Gly Ser Asp Ile Ser Lys Thr 
            20                  25                  30          


Cys Cys Phe Gln Tyr Ser His Lys Pro Leu Pro Trp Thr Trp Val Arg 
        35                  40                  45              


Ser Tyr Glu Phe Thr Ser Asn Ser Cys Ser Gln Arg Ala Val Ile Phe 
    50                  55                  60                  


Thr Thr Lys Arg Gly Lys Lys Val Cys Thr His Pro Arg Lys Lys Trp 
65                  70                  75                  80  


Val Gln Lys Tyr Ile Ser Leu Leu Lys Thr Pro Lys Gln Leu 
                85                  90                  


<210>  2157
<211>  112
<212>  PRT
<213>  Homo Sapiens

<400>  2157

Met Lys Gly Pro Pro Thr Phe Cys Ser Leu Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Leu Ser Pro Asp Pro Thr Ala Ala Phe Leu Leu Pro Pro Ser Thr Ala 
            20                  25                  30          


Cys Cys Thr Gln Leu Tyr Arg Lys Pro Leu Ser Asp Lys Leu Leu Arg 
        35                  40                  45              


Lys Val Ile Gln Val Glu Leu Gln Glu Ala Asp Gly Asp Cys His Leu 
    50                  55                  60                  


Gln Ala Phe Val Leu His Leu Ala Gln Arg Ser Ile Cys Ile His Pro 
65                  70                  75                  80  


Gln Asn Pro Ser Leu Ser Gln Trp Phe Glu His Gln Glu Arg Lys Leu 
                85                  90                  95      


His Gly Thr Leu Pro Lys Leu Asn Phe Gly Met Leu Arg Lys Met Gly 
            100                 105                 110         


<210>  2158
<211>  80
<212>  PRT
<213>  Homo Sapiens

<400>  2158

Met Cys Arg Ile Gln Arg Ala Asp Gly Asp Cys Asp Leu Ala Ala Val 
1               5                   10                  15      


Ile Leu His Val Lys Arg Arg Arg Ile Cys Val Ser Pro His Asn His 
            20                  25                  30          


Thr Val Lys Gln Trp Met Lys Val Gln Ala Ala Lys Lys Asn Gly Lys 
        35                  40                  45              


Gly Asn Val Cys His Arg Lys Lys His His Gly Lys Arg Asn Ser Asn 
    50                  55                  60                  


Arg Ala His Gln Gly Lys His Glu Thr Tyr Gly His Lys Thr Pro Tyr 
65                  70                  75                  80  


<210>  2159
<211>  127
<212>  PRT
<213>  Homo Sapiens

<400>  2159

Met Gln Gln Arg Gly Leu Ala Ile Val Ala Leu Ala Val Cys Ala Ala 
1               5                   10                  15      


Leu His Ala Ser Glu Ala Ile Leu Pro Ile Ala Ser Ser Cys Cys Thr 
            20                  25                  30          


Glu Val Ser His His Ile Ser Arg Arg Leu Leu Glu Arg Val Asn Met 
        35                  40                  45              


Cys Arg Ile Gln Arg Ala Asp Gly Asp Cys Asp Leu Ala Ala Val Ile 
    50                  55                  60                  


Leu His Val Lys Arg Arg Arg Ile Cys Val Ser Pro His Asn His Thr 
65                  70                  75                  80  


Val Lys Gln Trp Met Lys Val Gln Ala Ala Lys Lys Asn Gly Lys Gly 
                85                  90                  95      


Asn Val Cys His Arg Lys Lys His His Gly Lys Arg Asn Ser Asn Arg 
            100                 105                 110         


Ala His Gln Gly Lys His Glu Thr Tyr Gly His Lys Thr Pro Tyr 
        115                 120                 125         


<210>  2160
<211>  127
<212>  PRT
<213>  Homo Sapiens

<400>  2160

Met Gln Gln Arg Gly Leu Ala Ile Val Ala Leu Ala Val Cys Ala Ala 
1               5                   10                  15      


Leu His Ala Ser Glu Ala Ile Leu Pro Ile Ala Ser Ser Cys Cys Thr 
            20                  25                  30          


Glu Val Ser His His Ile Ser Arg Arg Leu Leu Glu Arg Val Asn Met 
        35                  40                  45              


Cys Arg Ile Gln Arg Ala Asp Gly Asp Cys Asp Leu Ala Ala Val Ile 
    50                  55                  60                  


Leu His Val Lys Arg Arg Arg Ile Cys Val Ser Pro His Asn His Thr 
65                  70                  75                  80  


Val Lys Gln Trp Met Lys Val Gln Ala Ala Lys Lys Asn Gly Lys Gly 
                85                  90                  95      


Asn Val Cys His Arg Lys Lys His His Gly Lys Arg Asn Ser Asn Arg 
            100                 105                 110         


Ala His Gln Gly Lys His Glu Thr Tyr Gly His Lys Thr Pro Tyr 
        115                 120                 125         


<210>  2161
<211>  92
<212>  PRT
<213>  Homo Sapiens

<400>  2161

Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Phe Ser Ala Ser Leu Ala Ala Asp Thr Pro Thr Ala 
            20                  25                  30          


Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile Ala 
        35                  40                  45              


Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Gly Val Ile Phe 
    50                  55                  60                  


Leu Thr Lys Arg Ser Arg Gln Val Cys Ala Asp Pro Ser Glu Glu Trp 
65                  70                  75                  80  


Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala 
                85                  90          


<210>  2162
<211>  93
<212>  PRT
<213>  Homo Sapiens

<400>  2162

Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Val Leu Ser Ala Pro Leu Ala Ala Asp Thr Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile 
        35                  40                  45              


Ala Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Ser Val Ile 
    50                  55                  60                  


Phe Leu Thr Lys Arg Gly Arg Gln Val Cys Ala Asp Pro Ser Glu Glu 
65                  70                  75                  80  


Trp Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala 
                85                  90              


<210>  2163
<211>  92
<212>  PRT
<213>  Homo Sapiens

<400>  2163

Met Lys Leu Cys Val Thr Val Leu Ser Leu Leu Met Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Pro Ala Leu Ser Ala Pro Met Gly Ser Asp Pro Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ala Arg Lys Leu Pro Arg Asn Phe Val 
        35                  40                  45              


Val Asp Tyr Tyr Glu Thr Ser Ser Leu Cys Ser Gln Pro Ala Val Val 
    50                  55                  60                  


Phe Gln Thr Lys Arg Ser Lys Gln Val Cys Ala Asp Pro Ser Glu Ser 
65                  70                  75                  80  


Trp Val Gln Glu Tyr Val Tyr Asp Leu Glu Leu Asn 
                85                  90          


<210>  2164
<211>  52
<212>  PRT
<213>  Homo Sapiens

<400>  2164

Met Lys Leu Cys Val Thr Val Leu Ser Leu Leu Met Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Pro Ala Leu Ser Ala Pro Asn Ser Lys Pro Lys Glu Ala 
            20                  25                  30          


Ser Lys Ser Val Leu Ile Pro Val Asn Pro Gly Ser Arg Ser Thr Cys 
        35                  40                  45              


Met Thr Trp Asn 
    50          


<210>  2165
<211>  47
<212>  PRT
<213>  Homo Sapiens

<400>  2165

Met Lys Leu Cys Val Thr Val Leu Ser Leu Leu Val Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Leu Ala Leu Ser Ala Pro Lys Ala Ser Lys Ser Ala Leu 
            20                  25                  30          


Thr Pro Val Ser Pro Gly Ser Arg Ser Thr Cys Met Thr Trp Asn 
        35                  40                  45          


<210>  2166
<211>  64
<212>  PRT
<213>  Homo Sapiens

<400>  2166

Met Lys Leu Cys Val Thr Val Leu Ser Leu Leu Val Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Leu Ala Leu Ser Ala Pro Met Gly Ser Asp Pro Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ala Arg Lys Leu Pro Arg Asn Phe Val 
        35                  40                  45              


Val Asp Tyr Tyr Glu Thr Ser Ser Leu Cys Ser Gln Pro Ala Val Val 
    50                  55                  60                  


<210>  2167
<211>  64
<212>  PRT
<213>  Homo Sapiens

<400>  2167

Met Lys Leu Cys Val Thr Val Leu Ser Leu Leu Val Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Leu Ala Leu Ser Ala Pro Met Gly Ser Asp Pro Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ala Arg Lys Leu Pro Arg Asn Phe Val 
        35                  40                  45              


Val Asp Tyr Tyr Glu Thr Ser Ser Leu Cys Ser Gln Pro Ala Val Val 
    50                  55                  60                  


<210>  2168
<211>  96
<212>  PRT
<213>  Homo Sapiens

<400>  2168

Met Lys Leu Cys Val Thr Val Leu Ser Leu Leu Val Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Leu Ala Leu Ser Ala Pro Met Gly Ser Asp Pro Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ala Arg Lys Leu Pro Arg Asn Phe Val 
        35                  40                  45              


Val Asp Tyr Tyr Glu Thr Ser Ser Leu Cys Ser Gln Pro Ala Val Val 
    50                  55                  60                  


Ala Ala Pro Gly Arg Ile Pro Ser Thr Arg Ala Ala Pro His Gly Pro 
65                  70                  75                  80  


Trp Ser Gly Arg Gly Arg Cys Leu Pro Gln Ala Arg Asp Lys Ala Arg 
                85                  90                  95      


<210>  2169
<211>  86
<212>  PRT
<213>  Homo Sapiens

<400>  2169

Met Lys Leu Cys Val Thr Val Leu Ser Leu Leu Val Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Leu Ala Leu Ser Ala Pro Met Gly Ser Asp Pro Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ala Arg Lys Leu Pro Arg Asn Phe Val 
        35                  40                  45              


Val Asp Tyr Tyr Glu Thr Ser Ser Leu Cys Ser Gln Pro Ala Val Val 
    50                  55                  60                  


Ala Ala Pro His Gly Pro Trp Ser Gly Arg Gly Arg Cys Leu Pro Gln 
65                  70                  75                  80  


Ala Arg Asp Lys Ala Arg 
                85      


<210>  2170
<211>  103
<212>  PRT
<213>  Homo Sapiens

<400>  2170

Met Lys Leu Cys Val Thr Val Leu Ser Leu Leu Val Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Leu Ala Leu Ser Ala Pro Met Gly Ser Asp Pro Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ala Arg Lys Leu Pro Arg Asn Phe Val 
        35                  40                  45              


Val Asp Tyr Tyr Glu Thr Ser Ser Leu Cys Ser Gln Pro Ala Val Val 
    50                  55                  60                  


Glu Trp Lys Leu Gln Gly Val Cys Phe Gln Cys Cys Ser Gly Lys Asp 
65                  70                  75                  80  


Pro Ile His Gln Ser Cys Pro Thr Trp Thr Met Val Arg Gln Arg Lys 
                85                  90                  95      


Met Pro Thr Thr Gly Lys Gly 
            100             


<210>  2171
<211>  92
<212>  PRT
<213>  Homo Sapiens

<400>  2171

Met Lys Leu Cys Val Thr Val Leu Ser Leu Leu Val Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Leu Ala Leu Ser Ala Pro Met Gly Ser Asp Pro Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ala Arg Lys Leu Pro Arg Asn Phe Val 
        35                  40                  45              


Val Asp Tyr Tyr Glu Thr Ser Ser Leu Cys Ser Gln Pro Ala Val Val 
    50                  55                  60                  


Phe Gln Thr Lys Arg Gly Lys Gln Val Cys Ala Asp Pro Ser Glu Ser 
65                  70                  75                  80  


Trp Val Gln Glu Tyr Val Tyr Asp Leu Glu Leu Asn 
                85                  90          


<210>  2172
<211>  87
<212>  PRT
<213>  Homo Sapiens

<400>  2172

Met Lys Leu Cys Val Thr Val Leu Ser Leu Leu Val Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Leu Ala Leu Ser Ala Pro Met Gly Ser Asp Pro Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ala Arg Lys Leu Pro Arg Asn Phe Val 
        35                  40                  45              


Val Asp Tyr Tyr Glu Thr Ser Ser Leu Cys Ser Gln Pro Ala Val Val 
    50                  55                  60                  


Gly Lys Gln Val Cys Ala Asp Pro Ser Glu Ser Trp Val Gln Glu Tyr 
65                  70                  75                  80  


Val Tyr Asp Leu Glu Leu Asn 
                85          


<210>  2173
<211>  103
<212>  PRT
<213>  Homo Sapiens

<400>  2173

Met Lys Leu Cys Val Thr Val Leu Ser Leu Leu Val Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Leu Ala Leu Ser Ala Pro Met Gly Ser Asp Pro Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ala Arg Lys Leu Pro Arg Asn Phe Val 
        35                  40                  45              


Val Asp Tyr Tyr Glu Thr Ser Ser Leu Cys Ser Gln Pro Ala Val Val 
    50                  55                  60                  


Tyr Arg Glu Ser Ala Ser Ser Ala Ala Pro Gly Arg Ile Pro Ser Thr 
65                  70                  75                  80  


Arg Ala Ala Pro His Gly Pro Trp Ser Gly Arg Gly Arg Cys Leu Pro 
                85                  90                  95      


Gln Ala Arg Asp Lys Ala Arg 
            100             


<210>  2174
<211>  68
<212>  PRT
<213>  Homo Sapiens

<400>  2174

Met Lys Leu Cys Val Thr Val Leu Ser Leu Leu Val Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Leu Ala Leu Ser Ala Pro Thr Lys Ser Ser Glu Trp Lys 
            20                  25                  30          


Leu Gln Gly Val Cys Phe Gln Cys Cys Ser Gly Lys Asp Pro Ile His 
        35                  40                  45              


Gln Ser Cys Pro Thr Trp Thr Met Val Arg Gln Arg Lys Met Pro Thr 
    50                  55                  60                  


Thr Gly Lys Gly 
65              


<210>  2175
<211>  91
<212>  PRT
<213>  Homo Sapiens

<400>  2175

Met Lys Val Ser Ala Ala Ala Leu Ala Val Ile Leu Ile Ala Thr Ala 
1               5                   10                  15      


Leu Cys Ala Pro Ala Ser Ala Ser Pro Tyr Ser Ser Asp Thr Thr Pro 
            20                  25                  30          


Cys Cys Phe Ala Tyr Ile Ala Arg Pro Leu Pro Arg Ala His Ile Lys 
        35                  40                  45              


Glu Tyr Phe Tyr Thr Ser Gly Lys Cys Ser Asn Pro Ala Val Val Phe 
    50                  55                  60                  


Val Thr Arg Lys Asn Arg Gln Val Cys Ala Asn Pro Glu Lys Lys Trp 
65                  70                  75                  80  


Val Arg Glu Tyr Ile Asn Ser Leu Glu Met Ser 
                85                  90      


<210>  2176
<211>  91
<212>  PRT
<213>  Homo Sapiens

<400>  2176

Met Lys Val Ser Ala Ala Ala Leu Ala Val Ile Leu Ile Ala Thr Ala 
1               5                   10                  15      


Leu Cys Ala Pro Ala Ser Ala Ser Pro Tyr Ser Ser Asp Thr Thr Pro 
            20                  25                  30          


Cys Cys Phe Ala Tyr Ile Ala Arg Pro Leu Pro Arg Ala His Ile Lys 
        35                  40                  45              


Glu Tyr Phe Tyr Thr Ser Gly Lys Cys Ser Asn Pro Ala Val Val Phe 
    50                  55                  60                  


Val Thr Arg Lys Asn Arg Gln Val Cys Ala Asn Pro Glu Lys Lys Trp 
65                  70                  75                  80  


Val Arg Glu Tyr Ile Asn Ser Leu Glu Met Ser 
                85                  90      


<210>  2177
<211>  150
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2177

Xaa Ala Ala Leu Ala Val Ile Leu Ile Ala Thr Ala Leu Cys Ala Pro 
1               5                   10                  15      


Ala Ser Ala Ser Pro Tyr Ser Ser Asp Thr Thr Pro Cys Cys Phe Ala 
            20                  25                  30          


Tyr Ile Ala Arg Pro Leu Pro Arg Ala His Ile Lys Glu Tyr Phe Tyr 
        35                  40                  45              


Thr Ser Gly Lys Cys Ser Asn Pro Ala Val Val His Arg Ser Arg Met 
    50                  55                  60                  


Pro Lys Arg Glu Gly Gln Gln Val Trp Gln Asp Phe Leu Tyr Asp Ser 
65                  70                  75                  80  


Arg Leu Asn Lys Gly Lys Leu Cys His Pro Lys Glu Pro Pro Ser Val 
                85                  90                  95      


Cys Gln Pro Arg Glu Glu Met Gly Ser Gly Val His Gln Leu Phe Gly 
            100                 105                 110         


Asp Glu Leu Gly Trp Arg Val Leu Glu Pro Glu Leu Thr Gln Ile Cys 
        115                 120                 125             


Leu Phe Leu Leu Ala Leu Val Leu Ala Trp Glu Ala Ser Pro His Tyr 
    130                 135                 140                 


Pro Thr Pro Pro Ala Pro 
145                 150 


<210>  2178
<211>  47
<212>  PRT
<213>  Homo Sapiens

<400>  2178

Met Lys Ala Ser Ala Ala Leu Leu Cys Leu Leu Leu Thr Ala Ala Ala 
1               5                   10                  15      


Phe Ser Pro Gln Gly Leu Ala Gln Pro Ala Ser Arg Pro Asn Trp Thr 
            20                  25                  30          


Arg Arg Ser Val Leu Thr Pro His Arg Ser Gly Ser Arg Thr Leu 
        35                  40                  45          


<210>  2179
<211>  81
<212>  PRT
<213>  Homo Sapiens

<400>  2179

Met Lys Ala Ser Ala Ala Leu Leu Cys Leu Leu Leu Thr Ala Ala Ala 
1               5                   10                  15      


Phe Ser Pro Gln Gly Leu Ala Gln Pro Glu Arg Pro Arg Thr His Pro 
            20                  25                  30          


Gln Trp Thr Phe Leu Leu Val Val Ser Leu Gln Leu Gly Leu Ile Leu 
        35                  40                  45              


Gln Leu Pro Ala Ala Thr Asp Leu Ser Ile Arg Lys Ser Leu Ser Arg 
    50                  55                  60                  


Gly Trp Arg Ala Thr Glu Gly Pro Pro Val Ala Thr Val Pro Gly Lys 
65                  70                  75                  80  


Leu 
    


<210>  2180
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  2180

Met Lys Ala Ser Ala Ala Leu Leu Cys Leu Leu Leu Thr Ala Ala Ala 
1               5                   10                  15      


Phe Ser Pro Gln Gly Leu Ala Gln Pro Val Gly Ile Asn Thr Ser Thr 
            20                  25                  30          


Thr Cys Cys Tyr Arg Phe Ile Asn Lys Lys Ile Pro Lys Gln Arg Leu 
        35                  40                  45              


Glu Ser Tyr Arg Arg Thr Thr Ser Ser His Cys Pro Arg Glu Ala Val 
    50                  55                  60                  


Ile Phe Lys Thr Lys Leu Asp Lys Glu Ile Cys Ala Asp Pro Thr Gln 
65                  70                  75                  80  


Lys Trp Val Gln Asp Phe Met Lys His Leu Asp Lys Lys Thr Gln Thr 
                85                  90                  95      


Pro Lys Leu 
            


<210>  2181
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  2181

Met Lys Val Ser Ala Ala Leu Leu Cys Leu Leu Leu Met Ala Ala Thr 
1               5                   10                  15      


Phe Ser Pro Gln Gly Leu Ala Gln Pro Asp Ser Val Ser Ile Pro Ile 
            20                  25                  30          


Thr Cys Cys Phe Asn Val Ile Asn Arg Lys Ile Pro Ile Gln Arg Leu 
        35                  40                  45              


Glu Ser Tyr Thr Arg Ile Thr Asn Ile Gln Cys Pro Lys Glu Ala Val 
    50                  55                  60                  


Ile Phe Lys Thr Lys Arg Gly Lys Glu Val Cys Ala Asp Pro Lys Glu 
65                  70                  75                  80  


Arg Trp Val Arg Asp Ser Met Lys His Leu Asp Gln Ile Phe Gln Asn 
                85                  90                  95      


Leu Lys Pro 
            


<210>  2182
<211>  68
<212>  PRT
<213>  Homo Sapiens

<400>  2182

Met Phe Ala Phe Leu Asn Val Val Val Thr Leu Ala Trp Pro Ser Gln 
1               5                   10                  15      


Leu Leu Leu Pro Leu Phe Ser Phe Trp Arg Pro His Tyr Pro Ile Met 
            20                  25                  30          


Ser Leu Cys Glu Asp Met Leu Leu Cys Asn Tyr Arg Lys Cys Arg Ile 
        35                  40                  45              


Lys Leu Ser Gly Tyr Ala Trp Val Thr Ala Cys Ser His Ile Phe Cys 
    50                  55                  60                  


Asp Gln His Gly 
65              


<210>  2183
<211>  4
<212>  PRT
<213>  Homo Sapiens

<400>  2183

Met Ser Leu Cys 
1               


<210>  2184
<211>  154
<212>  PRT
<213>  Homo Sapiens

<400>  2184

Met Ser Leu Cys Glu Asp Met Leu Leu Cys Asn Tyr Arg Lys Cys Arg 
1               5                   10                  15      


Ile Lys Leu Ser Gly Tyr Ala Trp Val Thr Ala Cys Ser His Ile Phe 
            20                  25                  30          


Cys Asp Gln His Gly Ser Gly Glu Phe Ser Arg Ser Pro Ala Ile Cys 
        35                  40                  45              


Pro Ala Cys Asn Ser Thr Leu Ser Gly Lys Leu Asp Ile Val Arg Thr 
    50                  55                  60                  


Glu Leu Ser Pro Ser Glu Glu Tyr Lys Ala Met Val Leu Ala Gly Leu 
65                  70                  75                  80  


Arg Pro Glu Ile Val Leu Asp Ile Ser Ser Arg Ala Leu Ala Phe Trp 
                85                  90                  95      


Thr Tyr Gln Val His Gln Glu Arg Leu Tyr Gln Glu Tyr Asn Phe Ser 
            100                 105                 110         


Lys Ala Glu Gly His Leu Lys Gln Met Glu Lys Ile Tyr Thr Gln Gln 
        115                 120                 125             


Ile Gln Ser Lys Asp Val Glu Leu Thr Ser Met Lys Gly Glu Val Thr 
    130                 135                 140                 


Ser Met Lys Lys Val Leu Glu Glu Tyr Lys 
145                 150                 


<210>  2185
<211>  277
<212>  PRT
<213>  Homo Sapiens

<400>  2185

Met Ser Leu Cys Glu Asp Met Leu Leu Cys Asn Tyr Arg Lys Cys Arg 
1               5                   10                  15      


Ile Lys Leu Ser Gly Tyr Ala Trp Val Thr Ala Cys Ser His Ile Phe 
            20                  25                  30          


Cys Asp Gln His Gly Ser Gly Glu Phe Ser Arg Ser Pro Ala Ile Cys 
        35                  40                  45              


Pro Ala Cys Asn Ser Thr Leu Ser Gly Lys Leu Asp Ile Val Arg Thr 
    50                  55                  60                  


Glu Leu Ser Pro Ser Glu Glu Tyr Lys Ala Met Val Leu Ala Gly Leu 
65                  70                  75                  80  


Arg Pro Glu Ile Val Leu Asp Ile Ser Ser Arg Ala Leu Ala Phe Trp 
                85                  90                  95      


Thr Tyr Gln Val His Gln Glu Arg Leu Tyr Gln Glu Tyr Asn Phe Ser 
            100                 105                 110         


Lys Ala Glu Gly His Leu Lys Gln Met Glu Lys Ile Tyr Thr Gln Gln 
        115                 120                 125             


Ile Gln Ser Lys Asp Val Glu Leu Thr Ser Met Lys Gly Glu Val Thr 
    130                 135                 140                 


Ser Met Lys Lys Val Leu Glu Glu Tyr Lys Lys Lys Phe Ser Asp Ile 
145                 150                 155                 160 


Ser Glu Lys Leu Met Glu Arg Asn Arg Gln Tyr Gln Lys Leu Gln Gly 
                165                 170                 175     


Leu Tyr Asp Ser Leu Arg Leu Arg Asn Ile Thr Ile Ala Asn His Glu 
            180                 185                 190         


Gly Thr Leu Glu Pro Ser Met Ile Ala Gln Ser Gly Val Leu Gly Phe 
        195                 200                 205             


Pro Leu Gly Asn Asn Ser Lys Phe Pro Leu Asp Asn Thr Pro Val Arg 
    210                 215                 220                 


Asn Arg Gly Asp Gly Asp Gly Asp Phe Gln Phe Arg Pro Phe Phe Ala 
225                 230                 235                 240 


Gly Ser Pro Thr Ala Pro Glu Pro Ser Asn Ser Phe Phe Ser Phe Val 
                245                 250                 255     


Ser Pro Ser Arg Glu Leu Glu Gln Gln Gln Val Ser Ser Arg Ala Phe 
            260                 265                 270         


Lys Val Lys Arg Ile 
        275         


<210>  2186
<211>  277
<212>  PRT
<213>  Homo Sapiens

<400>  2186

Met Ser Leu Cys Glu Asp Met Leu Leu Cys Asn Tyr Arg Lys Cys Arg 
1               5                   10                  15      


Ile Lys Leu Ser Gly Tyr Ala Trp Val Thr Ala Cys Ser His Ile Phe 
            20                  25                  30          


Cys Asp Gln His Gly Ser Gly Glu Phe Ser Arg Ser Pro Ala Ile Cys 
        35                  40                  45              


Pro Ala Cys Asn Ser Thr Leu Ser Gly Lys Leu Asp Ile Val Arg Thr 
    50                  55                  60                  


Glu Leu Ser Pro Ser Glu Glu Tyr Lys Ala Met Val Leu Ala Gly Leu 
65                  70                  75                  80  


Arg Pro Glu Ile Val Leu Asp Ile Ser Ser Arg Ala Leu Ala Phe Trp 
                85                  90                  95      


Thr Tyr Gln Val His Gln Glu Arg Leu Tyr Gln Glu Tyr Asn Phe Ser 
            100                 105                 110         


Lys Ala Glu Gly His Leu Lys Gln Met Glu Lys Ile Tyr Thr Gln Gln 
        115                 120                 125             


Ile Gln Ser Lys Asp Val Glu Leu Thr Ser Met Lys Gly Glu Val Thr 
    130                 135                 140                 


Ser Met Lys Lys Val Leu Glu Glu Tyr Lys Lys Lys Phe Ser Asp Ile 
145                 150                 155                 160 


Ser Glu Lys Leu Met Glu Arg Asn Arg Gln Tyr Gln Lys Leu Gln Gly 
                165                 170                 175     


Leu Tyr Asp Ser Leu Arg Leu Arg Asn Ile Thr Ile Ala Asn His Glu 
            180                 185                 190         


Gly Thr Leu Glu Pro Ser Met Ile Ala Gln Ser Gly Val Leu Gly Phe 
        195                 200                 205             


Pro Leu Gly Asn Asn Ser Lys Phe Pro Leu Asp Asn Thr Pro Val Arg 
    210                 215                 220                 


Asn Arg Gly Asp Gly Asp Gly Asp Phe Gln Phe Arg Pro Phe Phe Ala 
225                 230                 235                 240 


Gly Ser Pro Thr Ala Pro Glu Pro Ser Asn Ser Phe Phe Ser Phe Val 
                245                 250                 255     


Ser Pro Ser Arg Glu Leu Glu Gln Gln Gln Val Ser Ser Arg Ala Phe 
            260                 265                 270         


Lys Val Lys Arg Ile 
        275         


<210>  2187
<211>  277
<212>  PRT
<213>  Homo Sapiens

<400>  2187

Met Ser Leu Cys Glu Asp Met Leu Leu Cys Asn Tyr Arg Lys Cys Arg 
1               5                   10                  15      


Ile Lys Leu Ser Gly Tyr Ala Trp Val Thr Ala Cys Ser His Ile Phe 
            20                  25                  30          


Cys Asp Gln His Gly Ser Gly Glu Phe Ser Arg Ser Pro Ala Ile Cys 
        35                  40                  45              


Pro Ala Cys Asn Ser Thr Leu Ser Gly Lys Leu Asp Ile Val Arg Thr 
    50                  55                  60                  


Glu Leu Ser Pro Ser Glu Glu Tyr Lys Ala Met Val Leu Ala Gly Leu 
65                  70                  75                  80  


Arg Pro Glu Ile Val Leu Asp Ile Ser Ser Arg Ala Leu Ala Phe Trp 
                85                  90                  95      


Thr Tyr Gln Val His Gln Glu Arg Leu Tyr Gln Glu Tyr Asn Phe Ser 
            100                 105                 110         


Lys Ala Glu Gly His Leu Lys Gln Met Glu Lys Ile Tyr Thr Gln Gln 
        115                 120                 125             


Ile Gln Ser Lys Asp Val Glu Leu Thr Ser Met Lys Gly Glu Val Thr 
    130                 135                 140                 


Ser Met Lys Lys Val Leu Glu Glu Tyr Lys Lys Lys Phe Ser Asp Ile 
145                 150                 155                 160 


Ser Glu Lys Leu Met Glu Arg Asn Arg Gln Tyr Gln Lys Leu Gln Gly 
                165                 170                 175     


Leu Tyr Asp Ser Leu Arg Leu Arg Asn Ile Thr Ile Ala Asn His Glu 
            180                 185                 190         


Gly Thr Leu Glu Pro Ser Met Ile Ala Gln Ser Gly Val Leu Gly Phe 
        195                 200                 205             


Pro Leu Gly Asn Asn Ser Lys Phe Pro Leu Asp Asn Thr Pro Val Arg 
    210                 215                 220                 


Asn Arg Gly Asp Gly Asp Gly Asp Phe Gln Phe Arg Pro Phe Phe Ala 
225                 230                 235                 240 


Gly Ser Pro Thr Ala Pro Glu Pro Ser Asn Ser Phe Phe Ser Phe Val 
                245                 250                 255     


Ser Pro Ser Arg Glu Leu Glu Gln Gln Gln Val Ser Ser Arg Ala Phe 
            260                 265                 270         


Lys Val Lys Arg Ile 
        275         


<210>  2188
<211>  277
<212>  PRT
<213>  Homo Sapiens

<400>  2188

Met Ser Leu Cys Glu Asp Met Leu Leu Cys Asn Tyr Arg Lys Cys Arg 
1               5                   10                  15      


Ile Lys Leu Ser Gly Tyr Ala Trp Val Thr Ala Cys Ser His Ile Phe 
            20                  25                  30          


Cys Asp Gln His Gly Ser Gly Glu Phe Ser Arg Ser Pro Ala Ile Cys 
        35                  40                  45              


Pro Ala Cys Asn Ser Thr Leu Ser Gly Lys Leu Asp Ile Val Arg Thr 
    50                  55                  60                  


Glu Leu Ser Pro Ser Glu Glu Tyr Lys Ala Met Val Leu Ala Gly Leu 
65                  70                  75                  80  


Arg Pro Glu Ile Val Leu Asp Ile Ser Ser Arg Ala Leu Ala Phe Trp 
                85                  90                  95      


Thr Tyr Gln Val His Gln Glu Arg Leu Tyr Gln Glu Tyr Asn Phe Ser 
            100                 105                 110         


Lys Ala Glu Gly His Leu Lys Gln Met Glu Lys Ile Tyr Thr Gln Gln 
        115                 120                 125             


Ile Gln Ser Lys Asp Val Glu Leu Thr Ser Met Lys Gly Glu Val Thr 
    130                 135                 140                 


Ser Met Lys Lys Val Leu Glu Glu Tyr Lys Lys Lys Phe Ser Asp Ile 
145                 150                 155                 160 


Ser Glu Lys Leu Met Glu Arg Asn Arg Gln Tyr Gln Lys Leu Gln Gly 
                165                 170                 175     


Leu Tyr Asp Ser Leu Arg Leu Arg Asn Ile Thr Ile Ala Asn His Glu 
            180                 185                 190         


Gly Thr Leu Glu Pro Ser Met Ile Ala Gln Ser Gly Val Leu Gly Phe 
        195                 200                 205             


Pro Leu Gly Asn Asn Ser Lys Phe Pro Leu Asp Asn Thr Pro Val Arg 
    210                 215                 220                 


Asn Arg Gly Asp Gly Asp Gly Asp Phe Gln Phe Arg Pro Phe Phe Ala 
225                 230                 235                 240 


Gly Ser Pro Thr Ala Pro Glu Pro Ser Asn Ser Phe Phe Ser Phe Val 
                245                 250                 255     


Ser Pro Ser Arg Glu Leu Glu Gln Gln Gln Val Ser Ser Arg Ala Phe 
            260                 265                 270         


Lys Val Lys Arg Ile 
        275         


<210>  2189
<211>  277
<212>  PRT
<213>  Homo Sapiens

<400>  2189

Met Ser Leu Cys Glu Asp Met Leu Leu Cys Asn Tyr Arg Lys Cys Arg 
1               5                   10                  15      


Ile Lys Leu Ser Gly Tyr Ala Trp Val Thr Ala Cys Ser His Ile Phe 
            20                  25                  30          


Cys Asp Gln His Gly Ser Gly Glu Phe Ser Arg Ser Pro Ala Ile Cys 
        35                  40                  45              


Pro Ala Cys Asn Ser Thr Leu Ser Gly Lys Leu Asp Ile Val Arg Thr 
    50                  55                  60                  


Glu Leu Ser Pro Ser Glu Glu Tyr Lys Ala Met Val Leu Ala Gly Leu 
65                  70                  75                  80  


Arg Pro Glu Ile Val Leu Asp Ile Ser Ser Arg Ala Leu Ala Phe Trp 
                85                  90                  95      


Thr Tyr Gln Val His Gln Glu Arg Leu Tyr Gln Glu Tyr Asn Phe Ser 
            100                 105                 110         


Lys Ala Glu Gly His Leu Lys Gln Met Glu Lys Ile Tyr Thr Gln Gln 
        115                 120                 125             


Ile Gln Ser Lys Asp Val Glu Leu Thr Ser Met Lys Gly Glu Val Thr 
    130                 135                 140                 


Ser Met Lys Lys Val Leu Glu Glu Tyr Lys Lys Lys Phe Ser Asp Ile 
145                 150                 155                 160 


Ser Glu Lys Leu Met Glu Arg Asn Arg Gln Tyr Gln Lys Leu Gln Gly 
                165                 170                 175     


Leu Tyr Asp Ser Leu Arg Leu Arg Asn Ile Thr Ile Ala Asn His Glu 
            180                 185                 190         


Gly Thr Leu Glu Pro Ser Met Ile Ala Gln Ser Gly Val Leu Gly Phe 
        195                 200                 205             


Pro Leu Gly Asn Asn Ser Lys Phe Pro Leu Asp Asn Thr Pro Val Arg 
    210                 215                 220                 


Asn Arg Gly Asp Gly Asp Gly Asp Phe Gln Phe Arg Pro Phe Phe Ala 
225                 230                 235                 240 


Gly Ser Pro Thr Ala Pro Glu Pro Ser Asn Ser Phe Phe Ser Phe Val 
                245                 250                 255     


Ser Pro Ser Arg Glu Leu Glu Gln Gln Gln Val Ser Ser Arg Ala Phe 
            260                 265                 270         


Lys Val Lys Arg Ile 
        275         


<210>  2190
<211>  277
<212>  PRT
<213>  Homo Sapiens

<400>  2190

Met Ser Leu Cys Glu Asp Met Leu Leu Cys Asn Tyr Arg Lys Cys Arg 
1               5                   10                  15      


Ile Lys Leu Ser Gly Tyr Ala Trp Val Thr Ala Cys Ser His Ile Phe 
            20                  25                  30          


Cys Asp Gln His Gly Ser Gly Glu Phe Ser Arg Ser Pro Ala Ile Cys 
        35                  40                  45              


Pro Ala Cys Asn Ser Thr Leu Ser Gly Lys Leu Asp Ile Val Arg Thr 
    50                  55                  60                  


Glu Leu Ser Pro Ser Glu Glu Tyr Lys Ala Met Val Leu Ala Gly Leu 
65                  70                  75                  80  


Arg Pro Glu Ile Val Leu Asp Ile Ser Ser Arg Ala Leu Ala Phe Trp 
                85                  90                  95      


Thr Tyr Gln Val His Gln Glu Arg Leu Tyr Gln Glu Tyr Asn Phe Ser 
            100                 105                 110         


Lys Ala Glu Gly His Leu Lys Gln Met Glu Lys Ile Tyr Thr Gln Gln 
        115                 120                 125             


Ile Gln Ser Lys Asp Val Glu Leu Thr Ser Met Lys Gly Glu Val Thr 
    130                 135                 140                 


Ser Met Lys Lys Val Leu Glu Glu Tyr Lys Lys Lys Phe Ser Asp Ile 
145                 150                 155                 160 


Ser Glu Lys Leu Met Glu Arg Asn Arg Gln Tyr Gln Lys Leu Gln Gly 
                165                 170                 175     


Leu Tyr Asp Ser Leu Arg Leu Arg Asn Ile Thr Ile Ala Asn His Glu 
            180                 185                 190         


Gly Thr Leu Glu Pro Ser Met Ile Ala Gln Ser Gly Val Leu Gly Phe 
        195                 200                 205             


Pro Leu Gly Asn Asn Ser Lys Phe Pro Leu Asp Asn Thr Pro Val Arg 
    210                 215                 220                 


Asn Arg Gly Asp Gly Asp Gly Asp Phe Gln Phe Arg Pro Phe Phe Ala 
225                 230                 235                 240 


Gly Ser Pro Thr Ala Pro Glu Pro Ser Asn Ser Phe Phe Ser Phe Val 
                245                 250                 255     


Ser Pro Ser Arg Glu Leu Glu Gln Gln Gln Val Ser Ser Arg Ala Phe 
            260                 265                 270         


Lys Val Lys Arg Ile 
        275         


<210>  2191
<211>  102
<212>  PRT
<213>  Homo Sapiens

<400>  2191

Met Ser Leu Cys Glu Asp Met Leu Leu Cys Asn Tyr Arg Lys Cys Arg 
1               5                   10                  15      


Ile Lys Leu Ser Gly Tyr Ala Trp Val Thr Ala Cys Ser His Ile Phe 
            20                  25                  30          


Cys Asp Gln His Gly Ser Gly Glu Phe Ser Arg Ser Pro Ala Ile Cys 
        35                  40                  45              


Pro Ala Cys Asn Ser Thr Leu Ser Gly Lys Leu Asp Ile Val Arg Thr 
    50                  55                  60                  


Glu Leu Ser Pro Ser Glu Glu Tyr Lys Ala Met Val Leu Ala Gly Leu 
65                  70                  75                  80  


Arg Pro Glu Ile Val Leu Asp Ile Ser Ser Arg Ala Leu Ala Phe Trp 
                85                  90                  95      


Thr Tyr Gln Tyr Phe Leu 
            100         


<210>  2192
<211>  64
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2192

Xaa Glu Phe Ser Arg Ser Pro Ala Ile Cys Pro Ala Cys Asn Ser Thr 
1               5                   10                  15      


Leu Ser Gly Lys Leu Asp Ile Val Arg Thr Glu Leu Ser Pro Ser Glu 
            20                  25                  30          


Glu Tyr Lys Ala Met Val Leu Ala Gly Leu Arg Pro Glu Ile Val Leu 
        35                  40                  45              


Asp Ile Ser Ser Arg Ala Leu Ala Phe Trp Thr Tyr Gln Tyr Phe Leu 
    50                  55                  60                  


<210>  2193
<211>  31
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2193

Xaa Thr Leu Ala Pro Glu Arg Trp Pro Ser Gly His Ile Arg Leu Val 
1               5                   10                  15      


Ser Asn Ser Trp Val Gln Ala Ile Leu Pro Pro Gln Pro Pro Glu 
            20                  25                  30      


<210>  2194
<211>  526
<212>  PRT
<213>  Homo Sapiens

<400>  2194

Met Ala Ser Gly Pro His Ser Thr Ala Thr Ala Ala Ala Ala Ala Ser 
1               5                   10                  15      


Ser Ala Ala Pro Ser Ala Gly Gly Ser Ser Ser Gly Thr Thr Thr Thr 
            20                  25                  30          


Thr Thr Thr Thr Thr Gly Gly Ile Leu Ile Gly Asp Arg Leu Tyr Ser 
        35                  40                  45              


Glu Val Ser Leu Thr Ile Asp His Ser Leu Ile Pro Glu Glu Arg Leu 
    50                  55                  60                  


Ser Pro Thr Pro Ser Met Gln Asp Gly Leu Asp Leu Pro Ser Glu Thr 
65                  70                  75                  80  


Asp Leu Arg Ile Leu Gly Cys Glu Leu Ile Gln Ala Ala Gly Ile Leu 
                85                  90                  95      


Leu Arg Leu Pro Gln Val Ala Met Ala Thr Gly Gln Val Leu Phe His 
            100                 105                 110         


Arg Phe Phe Tyr Ser Lys Ser Phe Val Lys His Ser Phe Glu Ile Val 
        115                 120                 125             


Ala Met Ala Cys Ile Asn Leu Ala Ser Lys Ile Glu Glu Ala Pro Arg 
    130                 135                 140                 


Arg Ile Arg Asp Val Ile Asn Val Phe His His Leu Arg Gln Leu Arg 
145                 150                 155                 160 


Gly Lys Arg Thr Pro Ser Pro Leu Ile Leu Asp Gln Asn Tyr Ile Asn 
                165                 170                 175     


Thr Lys Asn Gln Val Ile Lys Ala Glu Arg Arg Val Leu Lys Glu Leu 
            180                 185                 190         


Gly Phe Cys Val His Val Lys His Pro His Lys Ile Ile Val Met Tyr 
        195                 200                 205             


Leu Gln Val Leu Glu Cys Glu Arg Asn Gln Thr Leu Val Gln Thr Ala 
    210                 215                 220                 


Trp Asn Tyr Met Asn Asp Ser Leu Arg Thr Asn Val Phe Val Arg Phe 
225                 230                 235                 240 


Gln Pro Glu Thr Ile Ala Cys Ala Cys Ile Tyr Leu Ala Ala Arg Ala 
                245                 250                 255     


Leu Gln Ile Pro Leu Pro Thr Arg Pro His Trp Phe Leu Leu Phe Gly 
            260                 265                 270         


Thr Thr Glu Glu Glu Ile Gln Glu Ile Cys Ile Glu Thr Leu Arg Leu 
        275                 280                 285             


Tyr Thr Arg Lys Lys Pro Asn Tyr Glu Leu Leu Glu Lys Glu Val Glu 
    290                 295                 300                 


Lys Arg Lys Val Ala Leu Gln Glu Ala Lys Leu Lys Ala Lys Gly Leu 
305                 310                 315                 320 


Asn Pro Asp Gly Thr Pro Ala Leu Ser Thr Leu Gly Gly Phe Ser Pro 
                325                 330                 335     


Ala Ser Lys Pro Ser Ser Pro Arg Glu Val Lys Ala Glu Glu Lys Ser 
            340                 345                 350         


Pro Ile Ser Ile Asn Val Lys Thr Val Lys Lys Glu Pro Glu Asp Arg 
        355                 360                 365             


Gln Gln Ala Ser Lys Ser Pro Tyr Asn Gly Val Arg Lys Asp Ser Lys 
    370                 375                 380                 


Arg Ser Arg Asn Ser Arg Ser Ala Ser Arg Ser Arg Ser Arg Thr Arg 
385                 390                 395                 400 


Ser Arg Ser Arg Ser His Thr Pro Arg Arg His Tyr Asn Asn Arg Arg 
                405                 410                 415     


Ser Arg Ser Gly Thr Tyr Ser Ser Arg Ser Arg Ser Arg Ser Arg Ser 
            420                 425                 430         


His Ser Glu Ser Pro Arg Arg His His Asn His Gly Ser Pro His Leu 
        435                 440                 445             


Lys Ala Lys His Thr Arg Asp Asp Leu Lys Ser Ser Asn Arg His Gly 
    450                 455                 460                 


His Lys Arg Lys Lys Ser Arg Ser Arg Ser Gln Ser Lys Ser Arg Asp 
465                 470                 475                 480 


His Ser Asp Ala Ala Lys Lys His Arg His Glu Arg Gly His His Arg 
                485                 490                 495     


Asp Arg Arg Glu Arg Ser Arg Ser Phe Glu Arg Ser His Lys Ser Lys 
            500                 505                 510         


His His Gly Gly Ser Arg Ser Gly His Gly Arg His Arg Arg 
        515                 520                 525     


<210>  2195
<211>  428
<212>  PRT
<213>  Homo Sapiens

<400>  2195

Met Ala Ser Gly Pro His Ser Thr Ala Thr Ala Ala Ala Ala Ala Ser 
1               5                   10                  15      


Ser Ala Ala Pro Ser Ala Gly Gly Ser Ser Ser Gly Thr Thr Thr Thr 
            20                  25                  30          


Thr Thr Thr Thr Thr Gly Gly Ile Leu Ile Gly Asp Arg Leu Tyr Ser 
        35                  40                  45              


Glu Val Ser Leu Thr Ile Asp His Ser Leu Ile Pro Glu Glu Arg Leu 
    50                  55                  60                  


Ser Pro Thr Pro Ser Met Gln Asp Gly Leu Asp Leu Pro Ser Glu Thr 
65                  70                  75                  80  


Asp Leu Arg Ile Leu Gly Cys Glu Leu Ile Gln Ala Ala Gly Ile Leu 
                85                  90                  95      


Leu Arg Leu Pro Gln Val Ala Met Ala Thr Gly Gln Val Leu Phe His 
            100                 105                 110         


Arg Phe Phe Tyr Ser Lys Ser Phe Val Lys His Ser Phe Glu Ile Val 
        115                 120                 125             


Ala Met Ala Cys Ile Asn Leu Ala Ser Lys Ile Glu Glu Ala Pro Arg 
    130                 135                 140                 


Arg Ile Arg Asp Val Ile Asn Val Phe His His Leu Arg Gln Leu Arg 
145                 150                 155                 160 


Gly Lys Arg Thr Pro Ser Pro Leu Ile Leu Asp Gln Asn Tyr Ile Asn 
                165                 170                 175     


Thr Lys Asn Gln Val Ile Lys Ala Glu Arg Arg Val Leu Lys Glu Leu 
            180                 185                 190         


Gly Phe Cys Val His Val Lys His Pro His Lys Ile Ile Val Met Tyr 
        195                 200                 205             


Leu Gln Val Leu Glu Cys Glu Arg Asn Gln Thr Leu Val Gln Thr Ala 
    210                 215                 220                 


Trp Asn Tyr Met Asn Asp Ser Leu Arg Thr Asn Val Phe Val Arg Phe 
225                 230                 235                 240 


Gln Pro Glu Thr Ile Ala Cys Ala Cys Ile Tyr Leu Ala Ala Arg Ala 
                245                 250                 255     


Leu Gln Ile Pro Leu Pro Thr Arg Pro His Trp Phe Leu Leu Phe Gly 
            260                 265                 270         


Thr Thr Glu Glu Glu Ile Gln Glu Ile Cys Ile Glu Thr Leu Arg Leu 
        275                 280                 285             


Tyr Thr Arg Lys Lys Pro Asn Tyr Glu Leu Leu Glu Lys Glu Val Glu 
    290                 295                 300                 


Lys Arg Lys Val Ala Leu Gln Glu Ala Lys Leu Lys Ala Lys Gly Leu 
305                 310                 315                 320 


Asn Pro Asp Gly Thr Pro Ala Leu Ser Thr Leu Gly Gly Phe Ser Pro 
                325                 330                 335     


Ala Ser Lys Pro Ser Ser Pro Arg Glu Val Lys Ala Glu Glu Lys Ser 
            340                 345                 350         


Pro Ile Ser Ile Asn Val Lys Thr Val Lys Lys Glu Pro Glu Asp Arg 
        355                 360                 365             


Gln Gln Ala Ser Lys Ser Pro Tyr Asn Gly Val Arg Lys Asp Ser Lys 
    370                 375                 380                 


Arg Ser Arg Asn Ser Arg Ser Ala Ser Arg Ser Arg Ser Arg Thr Arg 
385                 390                 395                 400 


Ser Arg Ser Arg Ser His Thr Pro Arg Arg Gln Asp Glu Val Leu Leu 
                405                 410                 415     


Arg Cys Pro Gly Arg Ser Arg Thr Pro Gly Leu Lys 
            420                 425             


<210>  2196
<211>  232
<212>  PRT
<213>  Homo Sapiens

<400>  2196

Met Ala Ser Gly Pro His Ser Thr Ala Thr Ala Ala Ala Ala Ala Ser 
1               5                   10                  15      


Ser Ala Ala Pro Ser Ala Gly Gly Ser Ser Ser Gly Thr Thr Thr Thr 
            20                  25                  30          


Thr Thr Thr Thr Thr Gly Gly Ile Leu Ile Gly Asp Arg Leu Tyr Ser 
        35                  40                  45              


Glu Val Ser Leu Thr Ile Asp His Ser Leu Ile Pro Glu Glu Arg Leu 
    50                  55                  60                  


Ser Pro Thr Pro Ser Met Gln Asp Gly Leu Asp Leu Pro Ser Glu Thr 
65                  70                  75                  80  


Asp Leu Arg Ile Leu Gly Cys Glu Leu Ile Gln Ala Ala Gly Ile Leu 
                85                  90                  95      


Leu Arg Leu Pro Gln Val Ala Met Ala Thr Gly Gln Val Leu Phe His 
            100                 105                 110         


Arg Phe Phe Tyr Ser Lys Ser Phe Val Lys His Ser Phe Glu Ile Val 
        115                 120                 125             


Ala Met Ala Cys Ile Asn Leu Ala Ser Lys Ile Glu Glu Ala Pro Arg 
    130                 135                 140                 


Arg Ile Arg Asp Val Ile Asn Val Phe His His Leu Arg Gln Leu Arg 
145                 150                 155                 160 


Gly Lys Arg Thr Pro Ser Pro Leu Ile Leu Asp Gln Asn Tyr Ile Asn 
                165                 170                 175     


Thr Lys Asn Gln Val Ile Lys Ala Glu Arg Arg Val Leu Lys Glu Leu 
            180                 185                 190         


Gly Phe Cys Val His Val Lys His Pro His Lys Ile Ile Val Met Tyr 
        195                 200                 205             


Leu Gln Val Leu Glu Cys Glu Arg Asn Gln Thr Leu Val Gln Thr Ala 
    210                 215                 220                 


Trp Val Val His Asp Gly Lys Ser 
225                 230         


<210>  2197
<211>  172
<212>  PRT
<213>  Homo Sapiens

<400>  2197

Met Ala Ser Gly Pro His Ser Thr Ala Thr Ala Ala Ala Ala Ala Ser 
1               5                   10                  15      


Ser Ala Ala Pro Ser Ala Gly Gly Ser Ser Ser Gly Thr Thr Thr Thr 
            20                  25                  30          


Thr Thr Thr Thr Thr Gly Gly Ile Leu Ile Gly Asp Arg Leu Tyr Ser 
        35                  40                  45              


Glu Val Ser Leu Thr Ile Asp His Ser Leu Ile Pro Glu Glu Arg Leu 
    50                  55                  60                  


Ser Pro Thr Pro Ser Met Gln Asp Gly Leu Asp Leu Pro Ser Glu Thr 
65                  70                  75                  80  


Asp Leu Arg Ile Leu Gly Cys Glu Leu Ile Gln Ala Ala Gly Ile Leu 
                85                  90                  95      


Leu Arg Leu Pro Gln Val Ala Met Ala Thr Gly Gln Val Leu Phe His 
            100                 105                 110         


Arg Phe Phe Tyr Ser Lys Ser Phe Val Lys His Ser Phe Glu Ile Val 
        115                 120                 125             


Ala Met Ala Cys Ile Asn Leu Ala Ser Lys Ile Glu Glu Ala Pro Arg 
    130                 135                 140                 


Arg Ile Arg Asp Val Ile Asn Val Phe His His Leu Arg Gln Leu Arg 
145                 150                 155                 160 


Gly Lys Ser Asp Gln Leu His Leu Pro Lys Pro Gly 
                165                 170         


<210>  2198
<211>  172
<212>  PRT
<213>  Homo Sapiens

<400>  2198

Met Ala Ser Gly Pro His Ser Thr Ala Thr Ala Ala Ala Ala Ala Ser 
1               5                   10                  15      


Ser Ala Ala Pro Ser Ala Gly Gly Ser Ser Ser Gly Thr Thr Thr Thr 
            20                  25                  30          


Thr Thr Thr Thr Thr Gly Gly Ile Leu Ile Gly Asp Arg Leu Tyr Ser 
        35                  40                  45              


Glu Val Ser Leu Thr Ile Asp His Ser Leu Ile Pro Glu Glu Arg Leu 
    50                  55                  60                  


Ser Pro Thr Pro Ser Met Gln Asp Gly Leu Asp Leu Pro Ser Glu Thr 
65                  70                  75                  80  


Asp Leu Arg Ile Leu Gly Cys Glu Leu Ile Gln Ala Ala Gly Ile Leu 
                85                  90                  95      


Leu Arg Leu Pro Gln Val Ala Met Ala Thr Gly Gln Val Leu Phe His 
            100                 105                 110         


Arg Phe Phe Tyr Ser Lys Ser Phe Val Lys His Ser Phe Glu Ile Val 
        115                 120                 125             


Ala Met Ala Cys Ile Asn Leu Ala Ser Lys Ile Glu Glu Ala Pro Arg 
    130                 135                 140                 


Arg Ile Arg Asp Val Ile Asn Val Phe His His Leu Arg Gln Leu Arg 
145                 150                 155                 160 


Gly Lys Ser Asp Gln Leu His Leu Pro Lys Pro Gly 
                165                 170         


<210>  2199
<211>  172
<212>  PRT
<213>  Homo Sapiens

<400>  2199

Met Ala Ser Gly Pro His Ser Thr Ala Thr Ala Ala Ala Ala Ala Ser 
1               5                   10                  15      


Ser Ala Ala Pro Ser Ala Gly Gly Ser Ser Ser Gly Thr Thr Thr Thr 
            20                  25                  30          


Thr Thr Thr Thr Thr Gly Gly Ile Leu Ile Gly Asp Arg Leu Tyr Ser 
        35                  40                  45              


Glu Val Ser Leu Thr Ile Asp His Ser Leu Ile Pro Glu Glu Arg Leu 
    50                  55                  60                  


Ser Pro Thr Pro Ser Met Gln Asp Gly Leu Asp Leu Pro Ser Glu Thr 
65                  70                  75                  80  


Asp Leu Arg Ile Leu Gly Cys Glu Leu Ile Gln Ala Ala Gly Ile Leu 
                85                  90                  95      


Leu Arg Leu Pro Gln Val Ala Met Ala Thr Gly Gln Val Leu Phe His 
            100                 105                 110         


Arg Phe Phe Tyr Ser Lys Ser Phe Val Lys His Ser Phe Glu Ile Val 
        115                 120                 125             


Ala Met Ala Cys Ile Asn Leu Ala Ser Lys Ile Glu Glu Ala Pro Arg 
    130                 135                 140                 


Arg Ile Arg Asp Val Ile Asn Val Phe His His Leu Arg Gln Leu Arg 
145                 150                 155                 160 


Gly Lys Ser Asp Gln Leu His Leu Pro Lys Pro Gly 
                165                 170         


<210>  2200
<211>  172
<212>  PRT
<213>  Homo Sapiens

<400>  2200

Met Ala Ser Gly Pro His Ser Thr Ala Thr Ala Ala Ala Ala Ala Ser 
1               5                   10                  15      


Ser Ala Ala Pro Ser Ala Gly Gly Ser Ser Ser Gly Thr Thr Thr Thr 
            20                  25                  30          


Thr Thr Thr Thr Thr Gly Gly Ile Leu Ile Gly Asp Arg Leu Tyr Ser 
        35                  40                  45              


Glu Val Ser Leu Thr Ile Asp His Ser Leu Ile Pro Glu Glu Arg Leu 
    50                  55                  60                  


Ser Pro Thr Pro Ser Met Gln Asp Gly Leu Asp Leu Pro Ser Glu Thr 
65                  70                  75                  80  


Asp Leu Arg Ile Leu Gly Cys Glu Leu Ile Gln Ala Ala Gly Ile Leu 
                85                  90                  95      


Leu Arg Leu Pro Gln Val Ala Met Ala Thr Gly Gln Val Leu Phe His 
            100                 105                 110         


Arg Phe Phe Tyr Ser Lys Ser Phe Val Lys His Ser Phe Glu Ile Val 
        115                 120                 125             


Ala Met Ala Cys Ile Asn Leu Ala Ser Lys Ile Glu Glu Ala Pro Arg 
    130                 135                 140                 


Arg Ile Arg Asp Val Ile Asn Val Phe His His Leu Arg Gln Leu Arg 
145                 150                 155                 160 


Gly Lys Ser Asp Gln Leu His Leu Pro Lys Pro Gly 
                165                 170         


<210>  2201
<211>  172
<212>  PRT
<213>  Homo Sapiens

<400>  2201

Met Ala Ser Gly Pro His Ser Thr Ala Thr Ala Ala Ala Ala Ala Ser 
1               5                   10                  15      


Ser Ala Ala Pro Ser Ala Gly Gly Ser Ser Ser Gly Thr Thr Thr Thr 
            20                  25                  30          


Thr Thr Thr Thr Thr Gly Gly Ile Leu Ile Gly Asp Arg Leu Tyr Ser 
        35                  40                  45              


Glu Val Ser Leu Thr Ile Asp His Ser Leu Ile Pro Glu Glu Arg Leu 
    50                  55                  60                  


Ser Pro Thr Pro Ser Met Gln Asp Gly Leu Asp Leu Pro Ser Glu Thr 
65                  70                  75                  80  


Asp Leu Arg Ile Leu Gly Cys Glu Leu Ile Gln Ala Ala Gly Ile Leu 
                85                  90                  95      


Leu Arg Leu Pro Gln Val Ala Met Ala Thr Gly Gln Val Leu Phe His 
            100                 105                 110         


Arg Phe Phe Tyr Ser Lys Ser Phe Val Lys His Ser Phe Glu Ile Val 
        115                 120                 125             


Ala Met Ala Cys Ile Asn Leu Ala Ser Lys Ile Glu Glu Ala Pro Arg 
    130                 135                 140                 


Arg Ile Arg Asp Val Ile Asn Val Phe His His Leu Arg Gln Leu Arg 
145                 150                 155                 160 


Gly Lys Ser Asp Gln Leu His Leu Pro Lys Pro Gly 
                165                 170         


<210>  2202
<211>  59
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2202

Xaa Arg Lys Lys Pro Asn Tyr Glu Leu Leu Glu Lys Glu Val Glu Lys 
1               5                   10                  15      


Arg Lys Val Ala Leu Gln Glu Ala Lys Leu Lys Ala Lys Gly Leu Asn 
            20                  25                  30          


Pro Asp Gly Thr Pro Ala Leu Ser Thr Leu Gly Gly Phe Ser Pro Ala 
        35                  40                  45              


Ser Lys Pro Cys Lys Met Tyr Leu Glu Leu Lys 
    50                  55                  


<210>  2203
<211>  520
<212>  PRT
<213>  Homo Sapiens

<400>  2203

Met Ala Ala Ala Ala Ala Ala Ala Gly Ala Ala Gly Ser Ala Ala Pro 
1               5                   10                  15      


Ala Ala Ala Ala Gly Ala Pro Gly Ser Gly Gly Ala Pro Ser Gly Ser 
            20                  25                  30          


Gln Gly Val Leu Ile Gly Asp Arg Leu Tyr Ser Gly Val Leu Ile Thr 
        35                  40                  45              


Leu Glu Asn Cys Leu Leu Pro Asp Asp Lys Leu Arg Phe Thr Pro Ser 
    50                  55                  60                  


Met Ser Ser Gly Leu Asp Thr Asp Thr Glu Thr Asp Leu Arg Val Val 
65                  70                  75                  80  


Gly Cys Glu Leu Ile Gln Ala Ala Gly Ile Leu Leu Arg Leu Pro Gln 
                85                  90                  95      


Val Ala Met Ala Thr Gly Gln Val Leu Phe Gln Arg Phe Phe Tyr Thr 
            100                 105                 110         


Lys Ser Phe Val Lys His Ser Met Glu His Val Ser Met Ala Cys Val 
        115                 120                 125             


His Leu Ala Ser Lys Ile Glu Glu Ala Pro Arg Arg Ile Arg Asp Val 
    130                 135                 140                 


Ile Asn Val Phe His Arg Leu Arg Gln Leu Arg Asp Lys Lys Lys Pro 
145                 150                 155                 160 


Val Pro Leu Leu Leu Asp Gln Asp Tyr Val Asn Leu Lys Asn Gln Ile 
                165                 170                 175     


Ile Lys Ala Glu Arg Arg Val Leu Lys Glu Leu Gly Phe Cys Val His 
            180                 185                 190         


Val Lys His Pro His Lys Ile Ile Val Met Tyr Leu Gln Val Leu Glu 
        195                 200                 205             


Cys Glu Arg Asn Gln His Leu Val Gln Thr Ser Trp Asn Tyr Met Asn 
    210                 215                 220                 


Asp Ser Leu Arg Thr Asp Val Phe Val Arg Phe Gln Pro Glu Ser Ile 
225                 230                 235                 240 


Ala Cys Ala Cys Ile Tyr Leu Ala Ala Arg Thr Leu Glu Ile Pro Leu 
                245                 250                 255     


Pro Asn Arg Pro His Trp Phe Leu Leu Phe Gly Ala Thr Glu Glu Glu 
            260                 265                 270         


Ile Gln Glu Ile Cys Leu Lys Ile Leu Gln Leu Tyr Ala Arg Lys Lys 
        275                 280                 285             


Val Asp Leu Thr His Leu Glu Gly Glu Val Glu Lys Arg Lys His Ala 
    290                 295                 300                 


Ile Glu Glu Ala Lys Ala Gln Ala Arg Gly Leu Leu Pro Gly Gly Thr 
305                 310                 315                 320 


Gln Val Leu Asp Gly Thr Ser Gly Phe Ser Pro Ala Pro Lys Leu Val 
                325                 330                 335     


Glu Ser Pro Lys Glu Gly Lys Gly Ser Lys Pro Ser Pro Leu Ser Val 
            340                 345                 350         


Lys Asn Thr Lys Arg Arg Leu Glu Gly Ala Lys Lys Ala Lys Ala Asp 
        355                 360                 365             


Ser Pro Val Asn Gly Leu Pro Lys Gly Arg Glu Ser Arg Ser Arg Ser 
    370                 375                 380                 


Arg Ser Arg Glu Gln Ser Tyr Ser Arg Ser Pro Ser Arg Ser Ala Ser 
385                 390                 395                 400 


Pro Lys Arg Arg Lys Ser Asp Ser Gly Ser Thr Ser Gly Gly Ser Lys 
                405                 410                 415     


Ser Gln Ser Arg Ser Arg Ser Arg Ser Asp Ser Pro Pro Arg Gln Ala 
            420                 425                 430         


Pro Arg Ser Ala Pro Tyr Lys Gly Ser Glu Ile Arg Gly Ser Arg Lys 
        435                 440                 445             


Ser Lys Asp Cys Lys Tyr Pro Gln Lys Pro His Lys Ser Arg Ser Arg 
    450                 455                 460                 


Ser Ser Ser Arg Ser Arg Ser Arg Ser Arg Glu Arg Ala Asp Asn Pro 
465                 470                 475                 480 


Gly Lys Tyr Lys Lys Lys Ser His Tyr Tyr Arg Asp Gln Arg Arg Glu 
                485                 490                 495     


Arg Ser Arg Ser Tyr Glu Arg Thr Gly Arg Arg Tyr Glu Arg Asp His 
            500                 505                 510         


Pro Gly His Ser Arg His Arg Arg 
        515                 520 


<210>  2204
<211>  236
<212>  PRT
<213>  Homo Sapiens

<400>  2204

Met Ala Ala Ala Ala Ala Ala Ala Gly Ala Ala Gly Ser Ala Ala Pro 
1               5                   10                  15      


Ala Ala Ala Ala Gly Ala Pro Gly Ser Gly Gly Ala Pro Ser Gly Ser 
            20                  25                  30          


Gln Gly Val Leu Ile Gly Asp Arg Leu Tyr Ser Gly Val Leu Ile Thr 
        35                  40                  45              


Leu Glu Asn Cys Leu Leu Pro Asp Asp Lys Leu Arg Phe Thr Pro Ser 
    50                  55                  60                  


Met Ser Ser Gly Leu Asp Thr Asp Thr Glu Thr Asp Leu Arg Val Val 
65                  70                  75                  80  


Gly Cys Glu Leu Ile Gln Ala Ala Gly Ile Leu Leu Arg Leu Pro Gln 
                85                  90                  95      


Val Ala Met Ala Thr Gly Gln Val Leu Phe Gln Arg Phe Phe Tyr Thr 
            100                 105                 110         


Lys Ser Phe Val Lys His Ser Met Glu His Val Ser Met Ala Cys Val 
        115                 120                 125             


His Leu Ala Ser Lys Ile Glu Glu Ala Pro Arg Arg Ile Arg Asp Val 
    130                 135                 140                 


Ile Asn Val Phe His Arg Leu Arg Gln Leu Arg Asp Lys Lys Lys Pro 
145                 150                 155                 160 


Val Pro Leu Leu Leu Asp Gln Asp Tyr Val Asn Leu Lys Asn Gln Ile 
                165                 170                 175     


Ile Lys Ala Glu Arg Arg Val Leu Lys Glu Leu Gly Phe Cys Val His 
            180                 185                 190         


Val Lys His Pro His Lys Ile Ile Val Met Tyr Leu Gln Val Leu Glu 
        195                 200                 205             


Cys Glu Arg Asn Gln His Leu Val Gln Thr Ser Trp Val Ala Ser Glu 
    210                 215                 220                 


Asp Pro Leu Leu Lys Trp Asp Ser Trp Gln Arg Leu 
225                 230                 235     


<210>  2205
<211>  227
<212>  PRT
<213>  Homo Sapiens

<400>  2205

Met Ala Ala Ala Ala Ala Ala Ala Gly Ala Ala Gly Ser Ala Ala Pro 
1               5                   10                  15      


Ala Ala Ala Ala Gly Ala Pro Gly Ser Gly Gly Ala Pro Ser Gly Ser 
            20                  25                  30          


Gln Gly Val Leu Ile Gly Asp Arg Leu Tyr Ser Gly Val Leu Ile Thr 
        35                  40                  45              


Leu Glu Asn Cys Leu Leu Pro Asp Asp Lys Leu Arg Phe Thr Pro Ser 
    50                  55                  60                  


Met Ser Ser Gly Leu Asp Thr Asp Thr Glu Thr Asp Leu Arg Val Val 
65                  70                  75                  80  


Gly Cys Glu Leu Ile Gln Ala Ala Gly Ile Leu Leu Arg Leu Pro Gln 
                85                  90                  95      


Val Ala Met Ala Thr Gly Gln Val Leu Phe Gln Arg Phe Phe Tyr Thr 
            100                 105                 110         


Lys Ser Phe Val Lys His Ser Met Glu His Val Ser Met Ala Cys Val 
        115                 120                 125             


His Leu Ala Ser Lys Ile Glu Glu Ala Pro Arg Arg Ile Arg Asp Val 
    130                 135                 140                 


Ile Asn Val Phe His Arg Leu Arg Gln Leu Arg Asp Lys Lys Lys Pro 
145                 150                 155                 160 


Val Pro Leu Leu Leu Asp Gln Asp Tyr Val Asn Leu Lys Asn Gln Ile 
                165                 170                 175     


Ile Lys Ala Glu Arg Arg Val Leu Lys Glu Leu Gly Phe Cys Val His 
            180                 185                 190         


Val Lys His Pro His Lys Ile Ile Val Met Tyr Leu Gln Val Leu Glu 
        195                 200                 205             


Cys Glu Arg Asn Gln His Leu Val Gln Thr Ser Trp Val Ala Ser Glu 
    210                 215                 220                 


Gly Ile Thr 
225         


<210>  2206
<211>  226
<212>  PRT
<213>  Homo Sapiens

<400>  2206

Met Ala Ala Ala Ala Ala Ala Ala Gly Ala Ala Gly Ser Ala Ala Pro 
1               5                   10                  15      


Ala Ala Ala Ala Gly Ala Pro Gly Ser Gly Gly Ala Pro Ser Gly Ser 
            20                  25                  30          


Gln Gly Val Leu Ile Gly Asp Arg Leu Tyr Ser Gly Val Leu Ile Thr 
        35                  40                  45              


Leu Glu Asn Cys Leu Leu Pro Asp Asp Lys Leu Arg Phe Thr Pro Ser 
    50                  55                  60                  


Met Ser Ser Gly Leu Asp Thr Asp Thr Glu Thr Asp Leu Arg Val Val 
65                  70                  75                  80  


Gly Cys Glu Leu Ile Gln Ala Ala Gly Ile Leu Leu Arg Leu Pro Gln 
                85                  90                  95      


Val Ala Met Ala Thr Gly Gln Val Leu Phe Gln Arg Phe Phe Tyr Thr 
            100                 105                 110         


Lys Ser Phe Val Lys His Ser Met Glu His Val Ser Met Ala Cys Val 
        115                 120                 125             


His Leu Ala Ser Lys Ile Glu Glu Ala Pro Arg Arg Ile Arg Asp Val 
    130                 135                 140                 


Ile Asn Val Phe His Arg Leu Arg Gln Leu Arg Asp Lys Lys Lys Pro 
145                 150                 155                 160 


Val Pro Leu Leu Leu Asp Gln Asp Tyr Val Asn Leu Lys Asn Gln Ile 
                165                 170                 175     


Ile Lys Ala Glu Arg Arg Val Leu Lys Glu Leu Gly Phe Cys Val His 
            180                 185                 190         


Val Lys His Pro His Lys Ile Ile Val Met Tyr Leu Gln Val Leu Glu 
        195                 200                 205             


Cys Glu Arg Asn Gln His Leu Val Gln Thr Ser Trp Val Ala Ser Glu 
    210                 215                 220                 


Gly Lys 
225     


<210>  2207
<211>  180
<212>  PRT
<213>  Homo Sapiens

<400>  2207

Met Ala Ala Ala Ala Ala Ala Ala Gly Ala Ala Gly Ser Ala Ala Pro 
1               5                   10                  15      


Ala Ala Ala Ala Gly Ala Pro Gly Ser Gly Gly Ala Pro Ser Gly Ser 
            20                  25                  30          


Gln Gly Val Leu Ile Gly Asp Arg Leu Tyr Ser Gly Val Leu Ile Thr 
        35                  40                  45              


Leu Glu Asn Cys Leu Leu Pro Asp Asp Lys Leu Arg Phe Thr Pro Ser 
    50                  55                  60                  


Met Ser Ser Gly Leu Asp Thr Asp Thr Glu Thr Asp Leu Arg Val Val 
65                  70                  75                  80  


Gly Cys Glu Leu Ile Gln Ala Ala Gly Ile Leu Leu Arg Leu Pro Gln 
                85                  90                  95      


Val Arg Ala Arg Pro Arg Ala Ser Gly Pro Gly Gly His Gly Tyr Arg 
            100                 105                 110         


Ala Gly Val Val Pro Ala Val Leu Leu Tyr Gln Val Leu Arg Glu Ala 
        115                 120                 125             


Leu His Gly Ala Cys Val Asn Gly Leu Cys Pro Pro Gly Phe Gln Asp 
    130                 135                 140                 


Arg Arg Gly Pro Lys Thr His Thr Gly Arg His Gln Cys Val Ser Pro 
145                 150                 155                 160 


Pro Ser Thr Ala Glu Arg Gln Lys Glu Ala Arg Ala Ser Thr Thr Gly 
                165                 170                 175     


Ser Arg Leu Cys 
            180 


<210>  2208
<211>  86
<212>  PRT
<213>  Homo Sapiens

<400>  2208

Met Ala Thr Gly Gln Val Leu Phe Gln Arg Phe Phe Tyr Thr Lys Ser 
1               5                   10                  15      


Phe Val Lys His Ser Met Glu His Val Ser Met Ala Cys Val His Leu 
            20                  25                  30          


Ala Ser Lys Ile Glu Glu Ala Pro Arg Arg Ile Arg Asp Val Ile Asn 
        35                  40                  45              


Val Phe His Arg Leu Arg Gln Leu Arg Asp Lys Lys Lys Pro Val Pro 
    50                  55                  60                  


Leu Leu Leu Asp Gln Asp Tyr Val Asn Leu Lys Asn Gln Ile Ile Lys 
65                  70                  75                  80  


Ala Glu Arg Arg Val Leu 
                85      


<210>  2209
<211>  347
<212>  PRT
<213>  Homo Sapiens

<400>  2209

Met Asn Asp Ser Leu Arg Thr Asp Val Phe Val Arg Phe Gln Pro Glu 
1               5                   10                  15      


Ser Ile Ala Cys Ala Cys Ile Tyr Leu Ala Ala Arg Thr Leu Glu Ile 
            20                  25                  30          


Pro Leu Pro Asn Arg Pro His Trp Phe Leu Leu Phe Gly Ala Thr Glu 
        35                  40                  45              


Glu Glu Ile Gln Glu Ile Cys Leu Lys Ile Leu Gln Leu Tyr Ala Arg 
    50                  55                  60                  


Lys Lys Val Asp Leu Thr His Leu Glu Gly Glu Val Glu Lys Arg Lys 
65                  70                  75                  80  


His Ala Ile Glu Glu Gly Pro Ser Pro Gly Pro Val Ala Trp Gly His 
                85                  90                  95      


Thr Gly Ala Gly Trp Tyr Leu Gly Val Leu Ser Cys Pro Gln Ala Gly 
            100                 105                 110         


Cys Trp Asp Tyr Ser Leu Glu Cys Ser Gly Ala Ile Trp Asp His Cys 
        115                 120                 125             


Lys Leu Arg Leu Pro Asp Ser Gly Asp Ser Cys Ala Ser Ala Ser Gln 
    130                 135                 140                 


Val Ala Gly Ile Ala Gly Ala His His His Ala Gln Ser Leu Ala Val 
145                 150                 155                 160 


Leu Pro Val Glu Ser Pro Lys Glu Gly Lys Gly Ser Lys Pro Ser Pro 
                165                 170                 175     


Leu Ser Val Lys Asn Thr Lys Arg Arg Leu Glu Gly Ala Lys Lys Ala 
            180                 185                 190         


Lys Ala Asp Ser Pro Val Asn Gly Leu Pro Lys Gly Arg Glu Ser Arg 
        195                 200                 205             


Ser Arg Ser Arg Ser Arg Glu Gln Ser Tyr Ser Arg Ser Pro Ser Arg 
    210                 215                 220                 


Ser Ala Ser Pro Lys Arg Arg Lys Ser Asp Ser Gly Ser Thr Ser Gly 
225                 230                 235                 240 


Gly Ser Lys Ser Gln Ser Arg Ser Arg Ser Arg Ser Asp Ser Pro Pro 
                245                 250                 255     


Arg Gln Ala Pro Arg Ser Ala Pro Tyr Lys Gly Ser Glu Ile Arg Gly 
            260                 265                 270         


Ser Arg Lys Ser Lys Asp Cys Lys Tyr Pro Gln Lys Pro His Lys Ser 
        275                 280                 285             


Arg Ser Arg Ser Ser Ser Arg Ser Arg Ser Arg Ser Arg Glu Arg Ala 
    290                 295                 300                 


Asp Asn Pro Gly Lys Tyr Lys Lys Lys Ser His Tyr Tyr Arg Asp Gln 
305                 310                 315                 320 


Arg Arg Glu Arg Ser Arg Ser Tyr Glu Arg Thr Gly Arg Arg Tyr Glu 
                325                 330                 335     


Arg Asp His Pro Gly His Ser Arg His Arg Arg 
            340                 345         


<210>  2210
<211>  46
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2210

Xaa Glu Glu Ala Pro Arg Arg Ile Arg Asp Val Ile Asn Val Phe His 
1               5                   10                  15      


Arg Leu Arg Gln Leu Arg Asp Lys Lys Pro Cys Ala Leu Ser Leu Ala 
            20                  25                  30          


Gly Ser Pro Cys Leu Tyr Tyr Trp Ile Lys Ile Met Leu Ile 
        35                  40                  45      


<210>  2211
<211>  55
<212>  PRT
<213>  Homo Sapiens

<400>  2211

Met Glu Arg Ala Ser Cys Leu Leu Leu Leu Leu Leu Pro Leu Val His 
1               5                   10                  15      


Val Ser Ala Thr Thr Pro Glu Pro Cys Glu Leu Asp Asp Glu Asp Phe 
            20                  25                  30          


Arg Cys Val Cys Asn Phe Ser Glu Pro Gln Pro Asp Trp Ser Glu Ala 
        35                  40                  45              


Phe Gln Cys Val Ser Ala Val 
    50                  55  


<210>  2212
<211>  81
<212>  PRT
<213>  Homo Sapiens

<400>  2212

Met Glu Arg Ala Ser Cys Leu Leu Leu Leu Leu Leu Pro Leu Val His 
1               5                   10                  15      


Val Ser Ala Thr Thr Pro Glu Pro Cys Glu Leu Asp Asp Glu Asp Phe 
            20                  25                  30          


Arg Cys Val Cys Asn Phe Ser Glu Pro Gln Pro Asp Trp Ser Glu Ala 
        35                  40                  45              


Phe Gln Cys Val Ser Ala Val Glu Val Glu Ile His Ala Gly Gly Leu 
    50                  55                  60                  


Asn Leu Glu Pro Phe Leu Lys Arg Val Asp Ala Asp Ala Asp Pro Arg 
65                  70                  75                  80  


Gln 
    


<210>  2213
<211>  213
<212>  PRT
<213>  Homo Sapiens

<400>  2213

Met Glu Arg Ala Ser Cys Leu Leu Leu Leu Leu Leu Pro Leu Val His 
1               5                   10                  15      


Val Ser Ala Thr Thr Pro Glu Pro Cys Glu Leu Asp Asp Glu Asp Phe 
            20                  25                  30          


Arg Cys Val Cys Asn Phe Ser Glu Pro Gln Pro Asp Trp Ser Glu Ala 
        35                  40                  45              


Phe Gln Cys Val Ser Ala Val Glu Val Glu Ile His Ala Gly Gly Leu 
    50                  55                  60                  


Asn Leu Glu Pro Phe Leu Lys Arg Val Asp Ala Asp Ala Asp Pro Arg 
65                  70                  75                  80  


Gln Tyr Ala Asp Thr Val Lys Ala Leu Arg Val Arg Arg Leu Thr Val 
                85                  90                  95      


Gly Ala Ala Gln Val Pro Ala Gln Leu Leu Val Gly Ala Leu Arg Val 
            100                 105                 110         


Leu Ala Tyr Ser Arg Leu Lys Glu Leu Thr Leu Glu Asp Leu Lys Ile 
        115                 120                 125             


Thr Gly Thr Met Pro Pro Leu Pro Leu Glu Ala Thr Gly Leu Ala Leu 
    130                 135                 140                 


Ser Ser Leu Arg Leu Arg Asn Val Ser Trp Ala Thr Gly Arg Ser Trp 
145                 150                 155                 160 


Leu Ala Glu Leu Gln Gln Trp Leu Lys Pro Gly Leu Lys Val Leu Ser 
                165                 170                 175     


Ile Ala Gln Ala His Ser Pro Ala Phe Ser Cys Glu Gln Val Arg Ala 
            180                 185                 190         


Phe Pro Ala Leu Thr Ser Leu Asp Leu Ser Asp Asn Pro Gly Leu Gly 
        195                 200                 205             


Glu Arg Gly Leu Met 
    210             


<210>  2214
<211>  375
<212>  PRT
<213>  Homo Sapiens

<400>  2214

Met Glu Arg Ala Ser Cys Leu Leu Leu Leu Leu Leu Pro Leu Val His 
1               5                   10                  15      


Val Ser Ala Thr Thr Pro Glu Pro Cys Glu Leu Asp Asp Glu Asp Phe 
            20                  25                  30          


Arg Cys Val Cys Asn Phe Ser Glu Pro Gln Pro Asp Trp Ser Glu Ala 
        35                  40                  45              


Phe Gln Cys Val Ser Ala Val Glu Val Glu Ile His Ala Gly Gly Leu 
    50                  55                  60                  


Asn Leu Glu Pro Phe Leu Lys Arg Val Asp Ala Asp Ala Asp Pro Arg 
65                  70                  75                  80  


Gln Tyr Ala Asp Thr Val Lys Ala Leu Arg Val Arg Arg Leu Thr Val 
                85                  90                  95      


Gly Ala Ala Gln Val Pro Ala Gln Leu Leu Val Gly Ala Leu Arg Val 
            100                 105                 110         


Leu Ala Tyr Ser Arg Leu Lys Glu Leu Thr Leu Glu Asp Leu Lys Ile 
        115                 120                 125             


Thr Gly Thr Met Pro Pro Leu Pro Leu Glu Ala Thr Gly Leu Ala Leu 
    130                 135                 140                 


Ser Ser Leu Arg Leu Arg Asn Val Ser Trp Ala Thr Gly Arg Ser Trp 
145                 150                 155                 160 


Leu Ala Glu Leu Gln Gln Trp Leu Lys Pro Gly Leu Lys Val Leu Ser 
                165                 170                 175     


Ile Ala Gln Ala His Ser Pro Ala Phe Ser Cys Glu Gln Val Arg Ala 
            180                 185                 190         


Phe Pro Ala Leu Thr Ser Leu Asp Leu Ser Asp Asn Pro Gly Leu Gly 
        195                 200                 205             


Glu Arg Gly Leu Met Ala Ala Leu Cys Pro His Lys Phe Pro Ala Ile 
    210                 215                 220                 


Gln Asn Leu Ala Leu Arg Asn Thr Gly Met Glu Thr Pro Thr Gly Val 
225                 230                 235                 240 


Cys Ala Ala Leu Ala Ala Ala Gly Val Gln Pro His Ser Leu Asp Leu 
                245                 250                 255     


Ser His Asn Ser Leu Arg Ala Thr Val Asn Pro Ser Ala Pro Arg Cys 
            260                 265                 270         


Met Trp Ser Ser Ala Leu Asn Ser Leu Asn Leu Ser Phe Ala Gly Leu 
        275                 280                 285             


Glu Gln Val Pro Lys Gly Leu Pro Ala Lys Leu Arg Val Leu Asp Leu 
    290                 295                 300                 


Ser Cys Asn Arg Leu Asn Arg Ala Pro Gln Pro Asp Glu Leu Pro Glu 
305                 310                 315                 320 


Val Asp Asn Leu Thr Leu Asp Gly Asn Pro Phe Leu Val Pro Gly Thr 
                325                 330                 335     


Ala Leu Pro His Glu Gly Ser Met Asn Ser Gly Val Val Pro Ala Cys 
            340                 345                 350         


Ala Arg Ser Thr Leu Ser Val Gly Val Ser Gly Thr Leu Val Leu Leu 
        355                 360                 365             


Gln Gly Ala Arg Gly Phe Ala 
    370                 375 


<210>  2215
<211>  375
<212>  PRT
<213>  Homo Sapiens

<400>  2215

Met Glu Arg Ala Ser Cys Leu Leu Leu Leu Leu Leu Pro Leu Val His 
1               5                   10                  15      


Val Ser Ala Thr Thr Pro Glu Pro Cys Glu Leu Asp Asp Glu Asp Phe 
            20                  25                  30          


Arg Cys Val Cys Asn Phe Ser Glu Pro Gln Pro Asp Trp Ser Glu Ala 
        35                  40                  45              


Phe Gln Cys Val Ser Ala Val Glu Val Glu Ile His Ala Gly Gly Leu 
    50                  55                  60                  


Asn Leu Glu Pro Phe Leu Lys Arg Val Asp Ala Asp Ala Asp Pro Arg 
65                  70                  75                  80  


Gln Tyr Ala Asp Thr Val Lys Ala Leu Arg Val Arg Arg Leu Thr Val 
                85                  90                  95      


Gly Ala Ala Gln Val Pro Ala Gln Leu Leu Val Gly Ala Leu Arg Val 
            100                 105                 110         


Leu Ala Tyr Ser Arg Leu Lys Glu Leu Thr Leu Glu Asp Leu Lys Ile 
        115                 120                 125             


Thr Gly Thr Met Pro Pro Leu Pro Leu Glu Ala Thr Gly Leu Ala Leu 
    130                 135                 140                 


Ser Ser Leu Arg Leu Arg Asn Val Ser Trp Ala Thr Gly Arg Ser Trp 
145                 150                 155                 160 


Leu Ala Glu Leu Gln Gln Trp Leu Lys Pro Gly Leu Lys Val Leu Ser 
                165                 170                 175     


Ile Ala Gln Ala His Ser Pro Ala Phe Ser Cys Glu Gln Val Arg Ala 
            180                 185                 190         


Phe Pro Ala Leu Thr Ser Leu Asp Leu Ser Asp Asn Pro Gly Leu Gly 
        195                 200                 205             


Glu Arg Gly Leu Met Ala Ala Leu Cys Pro His Lys Phe Pro Ala Ile 
    210                 215                 220                 


Gln Asn Leu Ala Leu Arg Asn Thr Gly Met Glu Thr Pro Thr Gly Val 
225                 230                 235                 240 


Cys Ala Ala Leu Ala Ala Ala Gly Val Gln Pro His Ser Leu Asp Leu 
                245                 250                 255     


Ser His Asn Ser Leu Arg Ala Thr Val Asn Pro Ser Ala Pro Arg Cys 
            260                 265                 270         


Met Trp Ser Ser Ala Leu Asn Ser Leu Asn Leu Ser Phe Ala Gly Leu 
        275                 280                 285             


Glu Gln Val Pro Lys Gly Leu Pro Ala Lys Leu Arg Val Leu Asp Leu 
    290                 295                 300                 


Ser Cys Asn Arg Leu Asn Arg Ala Pro Gln Pro Asp Glu Leu Pro Glu 
305                 310                 315                 320 


Val Asp Asn Leu Thr Leu Asp Gly Asn Pro Phe Leu Val Pro Gly Thr 
                325                 330                 335     


Ala Leu Pro His Glu Gly Ser Met Asn Ser Gly Val Val Pro Ala Cys 
            340                 345                 350         


Ala Arg Ser Thr Leu Ser Val Gly Val Ser Gly Thr Leu Val Leu Leu 
        355                 360                 365             


Gln Gly Ala Arg Gly Phe Ala 
    370                 375 


<210>  2216
<211>  72
<212>  PRT
<213>  Homo Sapiens

<400>  2216

Met Leu Leu Glu Pro Gly Arg Gly Cys Cys Ala Leu Ala Ile Leu Leu 
1               5                   10                  15      


Ala Ile Val Asp Ile Gln Ser Gly Glu Thr Gly Asn Tyr Thr Val Thr 
            20                  25                  30          


Gly Leu Lys Gln Arg Gln His Leu Glu Phe Ser His Asn Glu Gly Thr 
        35                  40                  45              


Leu Ser Ser Gly Phe Leu Gln Glu Lys Val Trp Val Met Leu Val Thr 
    50                  55                  60                  


Ser Leu Val Ala Leu Gln Ala Leu 
65                  70          


<210>  2217
<211>  125
<212>  PRT
<213>  Homo Sapiens

<400>  2217

Met Leu Leu Glu Pro Gly Arg Gly Cys Cys Ala Leu Ala Ile Leu Leu 
1               5                   10                  15      


Ala Ile Val Asp Ile Gln Ser Gly Glu Thr Gly Asn Tyr Thr Val Thr 
            20                  25                  30          


Gly Leu Lys Gln Arg Gln His Leu Glu Phe Ser His Asn Glu Gly Thr 
        35                  40                  45              


Leu Ser Ser Gly Phe Leu Gln Glu Lys Val Trp Val Met Leu Val Thr 
    50                  55                  60                  


Ser Leu Val Ala Leu Gln Gly Met Ser Lys Arg Ala Val Ser Thr Pro 
65                  70                  75                  80  


Ser Asn Glu Gly Ala Ile Ile Phe Leu Pro Pro Trp Leu Phe Ser Arg 
                85                  90                  95      


Arg Arg Arg Leu Glu Arg Met Ser Arg Gly Arg Glu Lys Cys Tyr Ser 
            100                 105                 110         


Ser Pro Gly Tyr Pro Gln Glu Ser Ser Asn Gln Phe His 
        115                 120                 125 


<210>  2218
<211>  181
<212>  PRT
<213>  Homo Sapiens

<400>  2218

Met Leu Leu Glu Pro Gly Arg Gly Cys Cys Ala Leu Ala Ile Leu Leu 
1               5                   10                  15      


Ala Ile Val Asp Ile Gln Ser Gly Gly Cys Ile Asn Ile Thr Ser Ser 
            20                  25                  30          


Ala Ser Gln Glu Gly Thr Arg Leu Asn Leu Ile Cys Thr Val Trp His 
        35                  40                  45              


Lys Lys Glu Glu Ala Glu Gly Phe Val Val Phe Leu Cys Lys Asp Arg 
    50                  55                  60                  


Ser Gly Asp Cys Ser Pro Glu Thr Ser Leu Lys Gln Leu Arg Leu Lys 
65                  70                  75                  80  


Arg Asp Pro Gly Ile Asp Gly Val Gly Glu Ile Ser Ser Gln Leu Met 
                85                  90                  95      


Phe Thr Ile Ser Gln Val Thr Pro Leu His Ser Gly Thr Tyr Gln Cys 
            100                 105                 110         


Cys Ala Arg Ser Gln Lys Ser Gly Ile Arg Leu Gln Gly His Phe Phe 
        115                 120                 125             


Ser Ile Leu Phe Thr Glu Thr Gly Asn Tyr Thr Val Thr Gly Leu Lys 
    130                 135                 140                 


Gln Arg Gln His Leu Glu Phe Ser His Asn Glu Gly Thr Leu Ser Ser 
145                 150                 155                 160 


Gly Phe Leu Gln Glu Lys Val Trp Val Met Leu Val Thr Ser Leu Val 
                165                 170                 175     


Ala Leu Gln Ala Leu 
            180     


<210>  2219
<211>  181
<212>  PRT
<213>  Homo Sapiens

<400>  2219

Met Leu Leu Glu Pro Gly Arg Gly Cys Cys Ala Leu Ala Ile Leu Leu 
1               5                   10                  15      


Ala Ile Val Asp Ile Gln Ser Gly Gly Cys Ile Asn Ile Thr Ser Ser 
            20                  25                  30          


Ala Ser Gln Glu Gly Thr Arg Leu Asn Leu Ile Cys Thr Val Trp His 
        35                  40                  45              


Lys Lys Glu Glu Ala Glu Gly Phe Val Val Phe Leu Cys Lys Asp Arg 
    50                  55                  60                  


Ser Gly Asp Cys Ser Pro Glu Thr Ser Leu Lys Gln Leu Arg Leu Lys 
65                  70                  75                  80  


Arg Asp Pro Gly Ile Asp Gly Val Gly Glu Ile Ser Ser Gln Leu Met 
                85                  90                  95      


Phe Thr Ile Ser Gln Val Thr Pro Leu His Ser Gly Thr Tyr Gln Cys 
            100                 105                 110         


Cys Ala Arg Ser Gln Lys Ser Gly Ile Arg Leu Gln Gly His Phe Phe 
        115                 120                 125             


Ser Ile Leu Phe Thr Glu Thr Gly Asn Tyr Thr Val Thr Gly Leu Lys 
    130                 135                 140                 


Gln Arg Gln His Leu Glu Phe Ser His Asn Glu Gly Thr Leu Ser Ser 
145                 150                 155                 160 


Gly Phe Leu Gln Glu Lys Val Trp Val Met Leu Val Thr Ser Leu Val 
                165                 170                 175     


Ala Leu Gln Ala Leu 
            180     


<210>  2220
<211>  234
<212>  PRT
<213>  Homo Sapiens

<400>  2220

Met Leu Leu Glu Pro Gly Arg Gly Cys Cys Ala Leu Ala Ile Leu Leu 
1               5                   10                  15      


Ala Ile Val Asp Ile Gln Ser Gly Gly Cys Ile Asn Ile Thr Ser Ser 
            20                  25                  30          


Ala Ser Gln Glu Gly Thr Arg Leu Asn Leu Ile Cys Thr Val Trp His 
        35                  40                  45              


Lys Lys Glu Glu Ala Glu Gly Phe Val Val Phe Leu Cys Lys Asp Arg 
    50                  55                  60                  


Ser Gly Asp Cys Ser Pro Glu Thr Ser Leu Lys Gln Leu Arg Leu Lys 
65                  70                  75                  80  


Arg Asp Pro Gly Ile Asp Gly Val Gly Glu Ile Ser Ser Gln Leu Met 
                85                  90                  95      


Phe Thr Ile Ser Gln Val Thr Pro Leu His Ser Gly Thr Tyr Gln Cys 
            100                 105                 110         


Cys Ala Arg Ser Gln Lys Ser Gly Ile Arg Leu Gln Gly His Phe Phe 
        115                 120                 125             


Ser Ile Leu Phe Thr Glu Thr Gly Asn Tyr Thr Val Thr Gly Leu Lys 
    130                 135                 140                 


Gln Arg Gln His Leu Glu Phe Ser His Asn Glu Gly Thr Leu Ser Ser 
145                 150                 155                 160 


Gly Phe Leu Gln Glu Lys Val Trp Val Met Leu Val Thr Ser Leu Val 
                165                 170                 175     


Ala Leu Gln Gly Met Ser Lys Arg Ala Val Ser Thr Pro Ser Asn Glu 
            180                 185                 190         


Gly Ala Ile Ile Phe Leu Pro Pro Trp Leu Phe Ser Arg Arg Arg Arg 
        195                 200                 205             


Leu Glu Arg Met Ser Arg Gly Arg Glu Lys Cys Tyr Ser Ser Pro Gly 
    210                 215                 220                 


Tyr Pro Gln Glu Ser Ser Asn Gln Phe His 
225                 230                 


<210>  2221
<211>  163
<212>  PRT
<213>  Homo Sapiens

<400>  2221

Met Arg Lys Gly Arg Lys Val Pro Met Tyr Val Pro Gly Val Leu Arg 
1               5                   10                  15      


Thr Tyr Pro Lys Ala Lys Leu Glu Glu Thr Cys Glu Gly Arg Asn Ser 
            20                  25                  30          


Cys Val Ser Cys Phe Asn Val Ser Val Val Asn Thr Thr Cys Phe Trp 
        35                  40                  45              


Ile Glu Cys Lys Asp Glu Ser Tyr Cys Ser His Asn Ser Thr Val Ser 
    50                  55                  60                  


Asp Cys Gln Val Gly Asn Thr Thr Asp Phe Cys Ser Val Ser Thr Ala 
65                  70                  75                  80  


Thr Pro Val Pro Thr Ala Asn Ser Thr Ala Lys Pro Thr Val Gln Pro 
                85                  90                  95      


Ser Pro Ser Thr Thr Ser Lys Thr Val Thr Thr Ser Gly Thr Thr Asn 
            100                 105                 110         


Asn Thr Val Thr Pro Thr Ser Gln Pro Val Arg Lys Ser Thr Phe Asp 
        115                 120                 125             


Ala Ala Ser Phe Ile Gly Gly Ile Val Leu Val Leu Gly Val Gln Ala 
    130                 135                 140                 


Val Ile Phe Phe Leu Tyr Lys Phe Cys Lys Ser Lys Glu Arg Asn Tyr 
145                 150                 155                 160 


His Thr Leu 
            


<210>  2222
<211>  184
<212>  PRT
<213>  Homo Sapiens

<400>  2222

Met Ser Arg Leu Ser Arg Ser Leu Leu Trp Ala Ala Thr Cys Leu Gly 
1               5                   10                  15      


Val Leu Cys Val Leu Ser Ala Asp Lys Asn Thr Thr Gln His Pro Asn 
            20                  25                  30          


Val Thr Thr Leu Ala Pro Ile Ser Asn Val Thr Ser Ala Pro Val Thr 
        35                  40                  45              


Ser Leu Pro Leu Val Thr Thr Pro Ala Pro Glu Thr Cys Glu Gly Arg 
    50                  55                  60                  


Asn Ser Cys Val Ser Cys Phe Asn Val Ser Val Val Asn Thr Thr Cys 
65                  70                  75                  80  


Phe Trp Ile Glu Cys Lys Asp Glu Ser Tyr Cys Ser His Asn Ser Thr 
                85                  90                  95      


Val Ser Asp Cys Gln Val Gly Asn Thr Thr Asp Phe Cys Ser Ala Lys 
            100                 105                 110         


Pro Thr Val Gln Pro Ser Pro Ser Thr Thr Ser Lys Thr Val Thr Thr 
        115                 120                 125             


Ser Gly Thr Thr Asn Asn Thr Val Thr Pro Thr Ser Gln Pro Val Arg 
    130                 135                 140                 


Lys Ser Thr Phe Asp Ala Ala Ser Phe Ile Gly Gly Ile Val Leu Val 
145                 150                 155                 160 


Leu Gly Val Gln Ala Val Ile Phe Phe Leu Tyr Lys Phe Cys Lys Ser 
                165                 170                 175     


Lys Glu Arg Asn Tyr His Thr Leu 
            180                 


<210>  2223
<211>  157
<212>  PRT
<213>  Homo Sapiens

<400>  2223

Met Ser Arg Leu Ser Arg Ser Leu Leu Trp Ala Ala Thr Cys Leu Gly 
1               5                   10                  15      


Val Leu Cys Val Leu Ser Ala Asp Lys Asn Thr Thr Gln His Pro Asn 
            20                  25                  30          


Val Thr Thr Leu Ala Pro Ile Ser Asn Val Thr Ser Ala Pro Val Thr 
        35                  40                  45              


Ser Leu Pro Leu Val Thr Thr Pro Ala Pro Glu Thr Cys Glu Gly Arg 
    50                  55                  60                  


Asn Ser Cys Val Ser Cys Phe Asn Val Ser Val Val Asn Thr Thr Cys 
65                  70                  75                  80  


Phe Trp Ile Glu Cys Lys Asp Glu Ser Tyr Cys Ser His Asn Ser Thr 
                85                  90                  95      


Val Ser Asp Cys Gln Val Gly Asn Thr Thr Asp Phe Cys Ser Val Ser 
            100                 105                 110         


Thr Ala Thr Pro Val Pro Thr Ala Asn Ser Thr Ala Lys Pro Thr Val 
        115                 120                 125             


Gln Pro Ser Pro Ser Thr Thr Ser Lys Thr Val Thr Thr Ser Glu Ile 
    130                 135                 140                 


Arg Cys His Thr Arg Asn Tyr Ile Pro Asp Leu Lys Lys 
145                 150                 155         


<210>  2224
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  2224

Met Ser Arg Leu Ser Arg Ser Leu Leu Trp Ala Ala Thr Cys Leu Gly 
1               5                   10                  15      


Val Leu Cys Val Leu Ser Ala Asp Lys Asn Thr Thr Gln His Pro Asn 
            20                  25                  30          


Val Thr Thr Leu Ala Pro Ile Ser Asn Val Thr Ser Ala Pro Val Thr 
        35                  40                  45              


Ser Leu Pro Leu Val Thr Thr Pro Ala Pro Glu Thr Cys Glu Gly Arg 
    50                  55                  60                  


Asn Ser Cys Val Ser Cys Phe Asn Val Ser Val Val Asn Thr Thr Cys 
65                  70                  75                  80  


Phe Trp Ile Glu Cys Lys Asp Glu Ser Tyr Cys Ser His Asn Ser Thr 
                85                  90                  95      


Val Ser Asp Cys Gln Val Gly Asn Thr Thr Asp Phe Cys Ser Val Ser 
            100                 105                 110         


Thr Ala Thr Pro Val Pro Thr Ala Asn Ser Thr Ala Lys Pro Thr Val 
        115                 120                 125             


Gln Pro Ser Pro Ser Thr Thr Ser Lys Thr Val Thr Thr Ser Gly Thr 
    130                 135                 140                 


Thr Asn Asn Thr Val Thr Pro Thr Ser Gln Pro Val Arg Lys Ser Thr 
145                 150                 155                 160 


Phe Asp Ala Ala Ser Phe Ile Gly Gly Ile Val Leu Val Leu Glu Ile 
                165                 170                 175     


Arg Cys His Thr Arg Asn Tyr Ile Pro Asp Leu Lys Lys 
            180                 185                 


<210>  2225
<211>  197
<212>  PRT
<213>  Homo Sapiens

<400>  2225

Met Ser Arg Leu Ser Arg Ser Leu Leu Trp Ala Ala Thr Cys Leu Gly 
1               5                   10                  15      


Val Leu Cys Val Leu Ser Ala Asp Lys Asn Thr Thr Gln His Pro Asn 
            20                  25                  30          


Val Thr Thr Leu Ala Pro Ile Ser Asn Val Thr Ser Ala Pro Val Thr 
        35                  40                  45              


Ser Leu Pro Leu Val Thr Thr Pro Ala Pro Glu Thr Cys Glu Gly Arg 
    50                  55                  60                  


Asn Ser Cys Val Ser Cys Phe Asn Val Ser Val Val Asn Thr Thr Cys 
65                  70                  75                  80  


Phe Trp Ile Glu Cys Lys Asp Glu Ser Tyr Cys Ser His Asn Ser Thr 
                85                  90                  95      


Val Ser Asp Cys Gln Val Gly Asn Thr Thr Asp Phe Cys Ser Val Ser 
            100                 105                 110         


Thr Ala Thr Pro Val Pro Thr Ala Asn Ser Thr Ala Lys Pro Thr Val 
        115                 120                 125             


Gln Pro Ser Pro Ser Thr Thr Ser Lys Thr Val Thr Thr Ser Gly Thr 
    130                 135                 140                 


Thr Asn Asn Thr Val Thr Pro Thr Ser Gln Pro Val Arg Lys Ser Thr 
145                 150                 155                 160 


Phe Asp Ala Ala Ser Phe Ile Gly Gly Ile Val Leu Val Leu Gly Val 
                165                 170                 175     


Gln Ala Val Ile Phe Phe Leu Tyr Lys Phe Cys Lys Ser Lys Glu Arg 
            180                 185                 190         


Asn Tyr His Thr Leu 
        195         


<210>  2226
<211>  178
<212>  PRT
<213>  Homo Sapiens

<400>  2226

Met Ser Arg Leu Ser Arg Ser Leu Leu Trp Ala Ala Thr Cys Leu Gly 
1               5                   10                  15      


Val Leu Cys Val Leu Ser Ala Asp Lys Asn Thr Thr Gln His Pro Asn 
            20                  25                  30          


Val Thr Thr Leu Ala Pro Ile Ser Asn Val Thr Ser Ala Pro Val Thr 
        35                  40                  45              


Ser Leu Pro Leu Val Thr Thr Pro Ala Pro Glu Thr Cys Glu Gly Arg 
    50                  55                  60                  


Asn Ser Cys Val Ser Cys Phe Asn Val Ser Val Val Asn Thr Thr Cys 
65                  70                  75                  80  


Phe Trp Ile Glu Cys Lys Asp Glu Ser Tyr Cys Ser His Asn Ser Thr 
                85                  90                  95      


Val Ser Asp Cys Gln Val Gly Asn Thr Thr Asp Phe Cys Ser Val Ser 
            100                 105                 110         


Thr Ala Thr Pro Val Pro Thr Ala Asn Ser Thr Gly Thr Thr Asn Asn 
        115                 120                 125             


Thr Val Thr Pro Thr Ser Gln Pro Val Arg Lys Ser Thr Phe Asp Ala 
    130                 135                 140                 


Ala Ser Phe Ile Gly Gly Ile Val Leu Val Leu Gly Val Gln Ala Val 
145                 150                 155                 160 


Ile Phe Phe Leu Tyr Lys Phe Cys Lys Ser Lys Glu Arg Asn Tyr His 
                165                 170                 175     


Thr Leu 
        


<210>  2227
<211>  437
<212>  PRT
<213>  Homo Sapiens

<400>  2227

Met Ser Ala Val Leu Leu Leu Ala Leu Leu Gly Phe Ile Leu Pro Leu 
1               5                   10                  15      


Pro Gly Val Gln Ala Leu Leu Cys Gln Phe Gly Thr Val Gln His Val 
            20                  25                  30          


Trp Lys Val Ser Asp Leu Pro Arg Gln Trp Thr Pro Lys Asn Thr Ser 
        35                  40                  45              


Cys Asp Ser Gly Leu Gly Cys Gln Asp Thr Leu Met Leu Ile Glu Ser 
    50                  55                  60                  


Gly Pro Gln Val Ser Leu Val Leu Ser Lys Gly Cys Thr Glu Ala Lys 
65                  70                  75                  80  


Asp Gln Glu Pro Arg Val Thr Glu His Arg Met Gly Pro Gly Leu Ser 
                85                  90                  95      


Leu Ile Ser Tyr Thr Phe Val Cys Arg Gln Glu Asp Phe Cys Asn Asn 
            100                 105                 110         


Leu Val Asn Ser Leu Pro Leu Trp Ala Pro Gln Pro Pro Ala Asp Pro 
        115                 120                 125             


Gly Ser Leu Arg Cys Pro Val Cys Leu Ser Met Glu Gly Cys Leu Glu 
    130                 135                 140                 


Gly Thr Thr Glu Glu Ile Cys Pro Lys Gly Thr Thr His Cys Tyr Asp 
145                 150                 155                 160 


Gly Leu Leu Arg Leu Arg Gly Gly Gly Ile Phe Ser Asn Leu Arg Val 
                165                 170                 175     


Gln Gly Cys Met Pro Gln Pro Val Cys Asn Leu Leu Asn Gly Thr Gln 
            180                 185                 190         


Glu Ile Gly Pro Val Gly Met Thr Glu Asn Cys Asp Met Lys Asp Phe 
        195                 200                 205             


Leu Thr Cys His Arg Gly Thr Thr Ile Met Thr His Gly Asn Leu Ala 
    210                 215                 220                 


Gln Glu Pro Thr Asp Trp Thr Thr Ser Asn Thr Glu Met Cys Glu Val 
225                 230                 235                 240 


Gly Gln Val Cys Gln Glu Thr Leu Leu Leu Leu Asp Val Gly Leu Thr 
                245                 250                 255     


Ser Thr Leu Val Gly Thr Lys Gly Cys Ser Thr Val Gly Ala Gln Asn 
            260                 265                 270         


Ser Gln Lys Thr Thr Ile His Ser Ala Pro Pro Gly Val Leu Val Ala 
        275                 280                 285             


Ser Tyr Thr His Phe Cys Ser Ser Asp Leu Cys Asn Ser Ala Ser Ser 
    290                 295                 300                 


Ser Ser Val Leu Leu Asn Ser Leu Pro Pro Gln Ala Ala Pro Val Pro 
305                 310                 315                 320 


Gly Asp Arg Gln Cys Pro Thr Cys Val Gln Pro Leu Gly Thr Cys Ser 
                325                 330                 335     


Ser Gly Ser Pro Arg Met Thr Cys Pro Arg Gly Ala Thr His Cys Tyr 
            340                 345                 350         


Asp Gly Tyr Ile His Leu Ser Gly Gly Gly Leu Ser Thr Lys Met Ser 
        355                 360                 365             


Ile Gln Gly Cys Val Ala Gln Pro Ser Ser Phe Leu Leu Asn His Thr 
    370                 375                 380                 


Arg Gln Ile Gly Ile Phe Ser Ala Arg Glu Lys Arg Asp Val Gln Pro 
385                 390                 395                 400 


Pro Ala Ser Gln His Glu Gly Gly Gly Ala Glu Gly Leu Glu Ser Leu 
                405                 410                 415     


Thr Trp Gly Val Gly Leu Ala Leu Ala Pro Ala Leu Trp Trp Gly Val 
            420                 425                 430         


Val Cys Pro Ser Cys 
        435         


<210>  2228
<211>  145
<212>  PRT
<213>  Homo Sapiens

<400>  2228

Met Ser Ala Val Leu Leu Leu Ala Leu Leu Gly Phe Ile Leu Pro Leu 
1               5                   10                  15      


Pro Gly Val Gln Ala Leu Leu Cys Gln Phe Gly Thr Val Gln His Val 
            20                  25                  30          


Trp Lys Val Ser Asp Leu Pro Arg Gln Trp Thr Pro Lys Asn Thr Ser 
        35                  40                  45              


Cys Asp Ser Gly Leu Gly Cys Gln Asp Thr Leu Met Leu Ile Glu Ser 
    50                  55                  60                  


Gly Pro Gln Val Ser Leu Val Leu Ser Lys Gly Cys Thr Glu Ala Lys 
65                  70                  75                  80  


Asp Gln Glu Pro Arg Val Thr Glu His Arg Met Gly Pro Gly Leu Ser 
                85                  90                  95      


Leu Ile Ser Tyr Thr Phe Val Cys Arg Gln Glu Asp Phe Cys Asn Asn 
            100                 105                 110         


Leu Val Asn Ser Leu Pro Leu Trp Ala Pro Gln Pro Pro Ala Asp Pro 
        115                 120                 125             


Met Met Gly Ala Ala Glu Gly Pro Phe Gly Lys Ala Glu Gln Val Asp 
    130                 135                 140                 


Ser 
145 


<210>  2229
<211>  139
<212>  PRT
<213>  Homo Sapiens

<400>  2229

Met Ser Ala Val Leu Leu Leu Ala Leu Leu Gly Phe Ile Leu Pro Leu 
1               5                   10                  15      


Pro Gly Val Gln Ala Leu Leu Cys Gln Phe Gly Thr Val Gln His Val 
            20                  25                  30          


Trp Lys Val Ser Asp Leu Pro Arg Gln Trp Thr Pro Lys Asn Thr Ser 
        35                  40                  45              


Cys Asp Ser Gly Leu Gly Cys Gln Asp Thr Leu Met Leu Ile Glu Ser 
    50                  55                  60                  


Gly Pro Gln Val Ser Leu Val Leu Ser Lys Gly Cys Thr Glu Ala Lys 
65                  70                  75                  80  


Asp Gln Glu Pro Arg Val Thr Glu His Arg Met Gly Pro Gly Leu Ser 
                85                  90                  95      


Leu Ile Ser Tyr Thr Phe Val Cys Arg Gln Glu Asp Phe Cys Asn Asn 
            100                 105                 110         


Leu Val Asn Ser Leu Pro Leu Trp Ala Pro Gln Pro Pro Ala Gly Ala 
        115                 120                 125             


Cys Gly Arg Val Gly Arg Arg Gly Arg Gly Cys 
    130                 135                 


<210>  2230
<211>  286
<212>  PRT
<213>  Homo Sapiens

<400>  2230

Met Leu Leu Leu Phe Leu Leu Phe Glu Gly Leu Cys Cys Pro Gly Glu 
1               5                   10                  15      


Asn Thr Ala Ala Pro Gln Ala Leu Gln Ser Tyr His Leu Ala Ala Glu 
            20                  25                  30          


Glu Gln Leu Ser Phe Arg Met Leu Gln Thr Ser Ser Phe Ala Asn His 
        35                  40                  45              


Ser Trp Ala His Ser Glu Gly Ser Gly Trp Leu Gly Asp Leu Gln Thr 
    50                  55                  60                  


His Gly Trp Asp Thr Val Leu Gly Thr Ile Arg Phe Leu Lys Pro Trp 
65                  70                  75                  80  


Ser His Gly Asn Phe Ser Lys Gln Glu Leu Lys Asn Leu Gln Ser Leu 
                85                  90                  95      


Phe Gln Leu Tyr Phe His Ser Phe Ile Gln Ile Val Gln Ala Ser Ala 
            100                 105                 110         


Gly Gln Phe Gln Leu Glu Leu Lys Pro Glu Ala Trp Leu Ser Cys Gly 
        115                 120                 125             


Pro Ser Pro Gly Pro Gly Arg Leu Gln Leu Val Cys His Val Ser Gly 
    130                 135                 140                 


Phe Tyr Pro Lys Pro Val Trp Val Met Trp Met Arg Gly Glu Gln Glu 
145                 150                 155                 160 


Gln Arg Gly Thr Gln Arg Gly Asp Val Leu Pro Asn Ala Asp Glu Thr 
                165                 170                 175     


Trp Tyr Leu Arg Ala Thr Leu Asp Val Ala Ala Gly Glu Ala Ala Gly 
            180                 185                 190         


Leu Ser Cys Arg Val Lys His Ser Ser Leu Gly Gly His Asp Leu Ile 
        195                 200                 205             


Ile His Trp Gly Gly Tyr Ser Ile Phe Leu Ile Leu Ile Cys Leu Thr 
    210                 215                 220                 


Val Ile Val Thr Leu Val Ile Leu Val Val Val Asp Ser Arg Leu Lys 
225                 230                 235                 240 


Lys Gln Ser Pro Val Phe Leu Met Gly Ala Asn Thr Gln Asp Thr Lys 
                245                 250                 255     


Asn Ser Arg His Gln Phe Cys Leu Ala Gln Val Ser Trp Ile Lys Asn 
            260                 265                 270         


Arg Val Leu Lys Lys Trp Lys Thr Arg Leu Asn Gln Leu Trp 
        275                 280                 285     


<210>  2231
<211>  298
<212>  PRT
<213>  Homo Sapiens

<400>  2231

Met Leu Leu Leu Phe Leu Leu Phe Glu Gly Leu Cys Cys Pro Gly Glu 
1               5                   10                  15      


Asn Thr Ala Ala Pro Gln Ala Leu Gln Ser Tyr His Leu Ala Ala Glu 
            20                  25                  30          


Glu Gln Leu Ser Phe Arg Met Leu Gln Thr Ser Ser Phe Ala Asn His 
        35                  40                  45              


Ser Trp Ala His Ser Glu Gly Ser Gly Trp Leu Gly Asp Leu Gln Thr 
    50                  55                  60                  


His Gly Trp Asp Thr Val Leu Gly Thr Ile Arg Phe Leu Lys Pro Trp 
65                  70                  75                  80  


Ser His Gly Asn Phe Ser Lys Gln Glu Leu Lys Asn Leu Gln Ser Leu 
                85                  90                  95      


Phe Gln Leu Tyr Phe His Ser Phe Ile Gln Ile Val Gln Ala Ser Ala 
            100                 105                 110         


Gly Gln Phe Gln Leu Glu Leu Lys Pro Glu Ala Trp Leu Ser Cys Gly 
        115                 120                 125             


Pro Ser Pro Gly Pro Gly Arg Leu Gln Leu Val Cys His Val Ser Gly 
    130                 135                 140                 


Phe Tyr Pro Lys Pro Val Trp Val Met Trp Met Arg Gly Glu Gln Glu 
145                 150                 155                 160 


Gln Arg Gly Thr Gln Arg Gly Asp Val Leu Pro Asn Ala Asp Glu Thr 
                165                 170                 175     


Trp Tyr Leu Arg Ala Thr Leu Asp Val Ala Ala Gly Glu Ala Ala Gly 
            180                 185                 190         


Leu Ser Cys Arg Val Lys His Ser Ser Leu Gly Gly His Asp Leu Ile 
        195                 200                 205             


Ile His Trp Gly Gly Tyr Ser Ile Phe Leu Ile Leu Ile Cys Leu Thr 
    210                 215                 220                 


Val Ile Val Thr Leu Val Ile Leu Val Val Val Asp Ser Arg Leu Lys 
225                 230                 235                 240 


Lys Gln Ser Ser Asn Lys Asn Ile Leu Ser Pro His Thr Pro Ser Pro 
                245                 250                 255     


Val Phe Leu Met Gly Ala Asn Thr Gln Asp Thr Lys Asn Ser Arg His 
            260                 265                 270         


Gln Phe Cys Leu Ala Gln Val Ser Trp Ile Lys Asn Arg Val Leu Lys 
        275                 280                 285             


Lys Trp Lys Thr Arg Leu Asn Gln Leu Trp 
    290                 295             


<210>  2232
<211>  231
<212>  PRT
<213>  Homo Sapiens

<400>  2232

Met Leu Leu Leu Phe Leu Leu Phe Glu Gly Leu Cys Cys Pro Gly Glu 
1               5                   10                  15      


Asn Thr Ala Ala Pro Gln Ala Leu Gln Ser Tyr His Leu Ala Ala Glu 
            20                  25                  30          


Glu Gln Leu Ser Phe Arg Met Leu Gln Thr Ser Ser Phe Ala Asn His 
        35                  40                  45              


Ser Trp Ala His Ser Glu Gly Ser Gly Trp Leu Gly Asp Leu Gln Thr 
    50                  55                  60                  


His Gly Trp Asp Thr Val Leu Gly Thr Ile Arg Phe Leu Lys Pro Trp 
65                  70                  75                  80  


Ser His Gly Asn Phe Ser Lys Gln Glu Leu Lys Asn Leu Gln Ser Leu 
                85                  90                  95      


Phe Gln Leu Tyr Phe His Ser Phe Ile Gln Ile Val Gln Ala Ser Ala 
            100                 105                 110         


Gly Gln Phe Gln Leu Glu Leu Lys Pro Glu Ala Trp Leu Ser Cys Gly 
        115                 120                 125             


Pro Ser Pro Gly Pro Gly Arg Leu Gln Leu Val Cys His Val Ser Gly 
    130                 135                 140                 


Phe Tyr Pro Lys Pro Val Trp Val Met Trp Met Arg Gly Gly Tyr Ser 
145                 150                 155                 160 


Ile Phe Leu Ile Leu Ile Cys Leu Thr Val Ile Val Thr Leu Val Ile 
                165                 170                 175     


Leu Val Val Val Asp Ser Arg Leu Lys Lys Gln Ser Pro Val Phe Leu 
            180                 185                 190         


Met Gly Ala Asn Thr Gln Asp Thr Lys Asn Ser Arg His Gln Phe Cys 
        195                 200                 205             


Leu Ala Gln Val Ser Trp Ile Lys Asn Arg Val Leu Lys Lys Trp Lys 
    210                 215                 220                 


Thr Arg Leu Asn Gln Leu Trp 
225                 230     


<210>  2233
<211>  290
<212>  PRT
<213>  Homo Sapiens

<400>  2233

Met Leu Leu Leu Phe Leu Leu Phe Glu Gly Leu Cys Cys Pro Gly Glu 
1               5                   10                  15      


Asn Thr Ala Ala Pro Gln Ala Leu Gln Ser Tyr His Leu Ala Ala Glu 
            20                  25                  30          


Glu Gln Leu Ser Phe Arg Met Leu Gln Thr Ser Ser Phe Ala Asn His 
        35                  40                  45              


Ser Trp Ala His Ser Glu Gly Ser Gly Trp Leu Gly Asp Leu Gln Thr 
    50                  55                  60                  


His Gly Trp Asp Thr Val Leu Gly Thr Ile Arg Phe Leu Lys Pro Trp 
65                  70                  75                  80  


Ser His Gly Asn Phe Ser Lys Gln Glu Leu Lys Asn Leu Gln Ser Leu 
                85                  90                  95      


Phe Gln Leu Tyr Phe His Ser Phe Ile Gln Ile Val Gln Ala Ser Ala 
            100                 105                 110         


Gly Gln Phe Gln Leu Glu Tyr Pro Phe Glu Ile Gln Ile Leu Ala Gly 
        115                 120                 125             


Cys Arg Met Asn Ala Pro Gln Ile Phe Leu Asn Met Ala Tyr Gln Gly 
    130                 135                 140                 


Ser Asp Phe Leu Ser Phe Gln Gly Ile Ser Trp Glu Pro Ser Pro Gly 
145                 150                 155                 160 


Ala Gly Ile Arg Ala Gln Asn Ile Cys Lys Val Leu Asn Arg Tyr Leu 
                165                 170                 175     


Asp Ile Lys Glu Ile Leu Gln Ser Leu Leu Gly His Thr Cys Pro Arg 
            180                 185                 190         


Phe Leu Ala Gly Leu Met Glu Ala Gly Glu Ser Glu Leu Lys Arg Lys 
        195                 200                 205             


Val Lys Pro Glu Ala Trp Leu Ser Cys Gly Pro Ser Pro Gly Pro Gly 
    210                 215                 220                 


Arg Leu Gln Leu Val Cys His Val Ser Gly Phe Tyr Pro Lys Pro Val 
225                 230                 235                 240 


Trp Val Met Trp Met Arg Gly Glu Gln Glu Gln Arg Gly Thr Gln Arg 
                245                 250                 255     


Gly Asp Val Leu Pro Asn Ala Asp Glu Thr Trp Trp Ile Phe His Leu 
            260                 265                 270         


Ser His Pro Asp Leu Phe Asp Cys Asp Ser Tyr Pro Gly His Ile Gly 
        275                 280                 285             


Cys Ser 
    290 


<210>  2234
<211>  388
<212>  PRT
<213>  Homo Sapiens

<400>  2234

Met Leu Leu Leu Phe Leu Leu Phe Glu Gly Leu Cys Cys Pro Gly Glu 
1               5                   10                  15      


Asn Thr Ala Ala Pro Gln Ala Leu Gln Ser Tyr His Leu Ala Ala Glu 
            20                  25                  30          


Glu Gln Leu Ser Phe Arg Met Leu Gln Thr Ser Ser Phe Ala Asn His 
        35                  40                  45              


Ser Trp Ala His Ser Glu Gly Ser Gly Trp Leu Gly Asp Leu Gln Thr 
    50                  55                  60                  


His Gly Trp Asp Thr Val Leu Gly Thr Ile Arg Phe Leu Lys Pro Trp 
65                  70                  75                  80  


Ser His Gly Asn Phe Ser Lys Gln Glu Leu Lys Asn Leu Gln Ser Leu 
                85                  90                  95      


Phe Gln Leu Tyr Phe His Ser Phe Ile Gln Ile Val Gln Ala Ser Ala 
            100                 105                 110         


Gly Gln Phe Gln Leu Glu Tyr Pro Phe Glu Ile Gln Ile Leu Ala Gly 
        115                 120                 125             


Cys Arg Met Asn Ala Pro Gln Ile Phe Leu Asn Met Ala Tyr Gln Gly 
    130                 135                 140                 


Ser Asp Phe Leu Ser Phe Gln Gly Ile Ser Trp Glu Pro Ser Pro Gly 
145                 150                 155                 160 


Ala Gly Ile Arg Ala Gln Asn Ile Cys Lys Val Leu Asn Arg Tyr Leu 
                165                 170                 175     


Asp Ile Lys Glu Ile Leu Gln Ser Leu Leu Gly His Thr Cys Pro Arg 
            180                 185                 190         


Phe Leu Ala Gly Leu Met Glu Ala Gly Glu Ser Glu Leu Lys Arg Lys 
        195                 200                 205             


Val Lys Pro Glu Ala Trp Leu Ser Cys Gly Pro Ser Pro Gly Pro Gly 
    210                 215                 220                 


Arg Leu Gln Leu Val Cys His Val Ser Gly Phe Tyr Pro Lys Pro Val 
225                 230                 235                 240 


Trp Val Met Trp Met Arg Gly Glu Gln Glu Gln Arg Gly Thr Gln Arg 
                245                 250                 255     


Gly Asp Val Leu Pro Asn Ala Asp Glu Thr Trp Tyr Leu Arg Ala Thr 
            260                 265                 270         


Leu Asp Val Ala Ala Gly Glu Ala Ala Gly Leu Ser Cys Arg Val Lys 
        275                 280                 285             


His Ser Ser Leu Gly Gly His Asp Leu Ile Ile His Trp Gly Gly Tyr 
    290                 295                 300                 


Ser Ile Phe Leu Ile Leu Ile Cys Leu Thr Val Ile Val Thr Leu Val 
305                 310                 315                 320 


Ile Leu Val Val Val Asp Ser Arg Leu Lys Lys Gln Ser Ser Asn Lys 
                325                 330                 335     


Asn Ile Leu Ser Pro His Thr Pro Ser Pro Val Phe Leu Met Gly Ala 
            340                 345                 350         


Asn Thr Gln Asp Thr Lys Asn Ser Arg His Gln Phe Cys Leu Ala Gln 
        355                 360                 365             


Val Ser Trp Ile Lys Asn Arg Val Leu Lys Lys Trp Lys Thr Arg Leu 
    370                 375                 380                 


Asn Gln Leu Trp 
385             


<210>  2235
<211>  376
<212>  PRT
<213>  Homo Sapiens

<400>  2235

Met Leu Leu Leu Phe Leu Leu Phe Glu Gly Leu Cys Cys Pro Gly Glu 
1               5                   10                  15      


Asn Thr Ala Ala Pro Gln Ala Leu Gln Ser Tyr His Leu Ala Ala Glu 
            20                  25                  30          


Glu Gln Leu Ser Phe Arg Met Leu Gln Thr Ser Ser Phe Ala Asn His 
        35                  40                  45              


Ser Trp Ala His Ser Glu Gly Ser Gly Trp Leu Gly Asp Leu Gln Thr 
    50                  55                  60                  


His Gly Trp Asp Thr Val Leu Gly Thr Ile Arg Phe Leu Lys Pro Trp 
65                  70                  75                  80  


Ser His Gly Asn Phe Ser Lys Gln Glu Leu Lys Asn Leu Gln Ser Leu 
                85                  90                  95      


Phe Gln Leu Tyr Phe His Ser Phe Ile Gln Ile Val Gln Ala Ser Ala 
            100                 105                 110         


Gly Gln Phe Gln Leu Glu Tyr Pro Phe Glu Ile Gln Ile Leu Ala Gly 
        115                 120                 125             


Cys Arg Met Asn Ala Pro Gln Ile Phe Leu Asn Met Ala Tyr Gln Gly 
    130                 135                 140                 


Ser Asp Phe Leu Ser Phe Gln Gly Ile Ser Trp Glu Pro Ser Pro Gly 
145                 150                 155                 160 


Ala Gly Ile Arg Ala Gln Asn Ile Cys Lys Val Leu Asn Arg Tyr Leu 
                165                 170                 175     


Asp Ile Lys Glu Ile Leu Gln Ser Leu Leu Gly His Thr Cys Pro Arg 
            180                 185                 190         


Phe Leu Ala Gly Leu Met Glu Ala Gly Glu Ser Glu Leu Lys Arg Lys 
        195                 200                 205             


Val Lys Pro Glu Ala Trp Leu Ser Cys Gly Pro Ser Pro Gly Pro Gly 
    210                 215                 220                 


Arg Leu Gln Leu Val Cys His Val Ser Gly Phe Tyr Pro Lys Pro Val 
225                 230                 235                 240 


Trp Val Met Trp Met Arg Gly Glu Gln Glu Gln Arg Gly Thr Gln Arg 
                245                 250                 255     


Gly Asp Val Leu Pro Asn Ala Asp Glu Thr Trp Tyr Leu Arg Ala Thr 
            260                 265                 270         


Leu Asp Val Ala Ala Gly Glu Ala Ala Gly Leu Ser Cys Arg Val Lys 
        275                 280                 285             


His Ser Ser Leu Gly Gly His Asp Leu Ile Ile His Trp Gly Gly Tyr 
    290                 295                 300                 


Ser Ile Phe Leu Ile Leu Ile Cys Leu Thr Val Ile Val Thr Leu Val 
305                 310                 315                 320 


Ile Leu Val Val Val Asp Ser Arg Leu Lys Lys Gln Ser Pro Val Phe 
                325                 330                 335     


Leu Met Gly Ala Asn Thr Gln Asp Thr Lys Asn Ser Arg His Gln Phe 
            340                 345                 350         


Cys Leu Ala Gln Val Ser Trp Ile Lys Asn Arg Val Leu Lys Lys Trp 
        355                 360                 365             


Lys Thr Arg Leu Asn Gln Leu Trp 
    370                 375     


<210>  2236
<211>  321
<212>  PRT
<213>  Homo Sapiens

<400>  2236

Met Leu Leu Leu Phe Leu Leu Phe Glu Gly Leu Cys Cys Pro Gly Glu 
1               5                   10                  15      


Asn Thr Ala Ala Pro Gln Ala Leu Gln Ser Tyr His Leu Ala Ala Glu 
            20                  25                  30          


Glu Gln Leu Ser Phe Arg Met Leu Gln Thr Ser Ser Phe Ala Asn His 
        35                  40                  45              


Ser Trp Ala His Ser Glu Gly Ser Gly Trp Leu Gly Asp Leu Gln Thr 
    50                  55                  60                  


His Gly Trp Asp Thr Val Leu Gly Thr Ile Arg Phe Leu Lys Pro Trp 
65                  70                  75                  80  


Ser His Gly Asn Phe Ser Lys Gln Glu Leu Lys Asn Leu Gln Ser Leu 
                85                  90                  95      


Phe Gln Leu Tyr Phe His Ser Phe Ile Gln Ile Val Gln Ala Ser Ala 
            100                 105                 110         


Gly Gln Phe Gln Leu Glu Tyr Pro Phe Glu Ile Gln Ile Leu Ala Gly 
        115                 120                 125             


Cys Arg Met Asn Ala Pro Gln Ile Phe Leu Asn Met Ala Tyr Gln Gly 
    130                 135                 140                 


Ser Asp Phe Leu Ser Phe Gln Gly Ile Ser Trp Glu Pro Ser Pro Gly 
145                 150                 155                 160 


Ala Gly Ile Arg Ala Gln Asn Ile Cys Lys Val Leu Asn Arg Tyr Leu 
                165                 170                 175     


Asp Ile Lys Glu Ile Leu Gln Ser Leu Leu Gly His Thr Cys Pro Arg 
            180                 185                 190         


Phe Leu Ala Gly Leu Met Glu Ala Gly Glu Ser Glu Leu Lys Arg Lys 
        195                 200                 205             


Val Lys Pro Glu Ala Trp Leu Ser Cys Gly Pro Ser Pro Gly Pro Gly 
    210                 215                 220                 


Arg Leu Gln Leu Val Cys His Val Ser Gly Phe Tyr Pro Lys Pro Val 
225                 230                 235                 240 


Trp Val Met Trp Met Arg Gly Gly Tyr Ser Ile Phe Leu Ile Leu Ile 
                245                 250                 255     


Cys Leu Thr Val Ile Val Thr Leu Val Ile Leu Val Val Val Asp Ser 
            260                 265                 270         


Arg Leu Lys Lys Gln Ser Pro Val Phe Leu Met Gly Ala Asn Thr Gln 
        275                 280                 285             


Asp Thr Lys Asn Ser Arg His Gln Phe Cys Leu Ala Gln Val Ser Trp 
    290                 295                 300                 


Ile Lys Asn Arg Val Leu Lys Lys Trp Lys Thr Arg Leu Asn Gln Leu 
305                 310                 315                 320 


Trp 
    


<210>  2237
<211>  289
<212>  PRT
<213>  Homo Sapiens

<400>  2237

Met Leu Leu Leu Phe Leu Leu Phe Glu Gly Leu Cys Cys Pro Gly Glu 
1               5                   10                  15      


Asn Thr Ala Asp Pro Phe Glu Ile Gln Ile Leu Ala Gly Cys Arg Met 
            20                  25                  30          


Asn Ala Pro Gln Ile Phe Leu Asn Met Ala Tyr Gln Gly Ser Asp Phe 
        35                  40                  45              


Leu Ser Phe Gln Gly Ile Ser Trp Glu Pro Ser Pro Gly Ala Gly Ile 
    50                  55                  60                  


Arg Ala Gln Asn Ile Cys Lys Val Leu Asn Arg Tyr Leu Asp Ile Lys 
65                  70                  75                  80  


Glu Ile Leu Gln Ser Leu Leu Gly His Thr Cys Pro Arg Phe Leu Ala 
                85                  90                  95      


Gly Leu Met Glu Ala Gly Glu Ser Glu Leu Lys Arg Lys Val Lys Pro 
            100                 105                 110         


Glu Ala Trp Leu Ser Cys Gly Pro Ser Pro Gly Pro Gly Arg Leu Gln 
        115                 120                 125             


Leu Val Cys His Val Ser Gly Phe Tyr Pro Lys Pro Val Trp Val Met 
    130                 135                 140                 


Trp Met Arg Gly Glu Gln Glu Gln Arg Gly Thr Gln Arg Gly Asp Val 
145                 150                 155                 160 


Leu Pro Asn Ala Asp Glu Thr Trp Tyr Leu Arg Ala Thr Leu Asp Val 
                165                 170                 175     


Ala Ala Gly Glu Ala Ala Gly Leu Ser Cys Arg Val Lys His Ser Ser 
            180                 185                 190         


Leu Gly Gly His Asp Leu Ile Ile His Trp Gly Gly Tyr Ser Ile Phe 
        195                 200                 205             


Leu Ile Leu Ile Cys Leu Thr Val Ile Val Thr Leu Val Ile Leu Val 
    210                 215                 220                 


Val Val Asp Ser Arg Leu Lys Lys Gln Ser Ser Asn Lys Asn Ile Leu 
225                 230                 235                 240 


Ser Pro His Thr Pro Ser Pro Val Phe Leu Met Gly Ala Asn Thr Gln 
                245                 250                 255     


Asp Thr Lys Asn Ser Arg His Gln Phe Cys Leu Ala Gln Val Ser Trp 
            260                 265                 270         


Ile Lys Asn Arg Val Leu Lys Lys Trp Lys Thr Arg Leu Asn Gln Leu 
        275                 280                 285             


Trp 
    


<210>  2238
<211>  101
<212>  PRT
<213>  Homo Sapiens

<400>  2238

Met Leu Leu Leu Phe Leu Leu Phe Glu Gly Leu Cys Cys Pro Gly Glu 
1               5                   10                  15      


Asn Thr Ala Val Lys Pro Glu Ala Trp Leu Ser Cys Gly Pro Ser Pro 
            20                  25                  30          


Gly Pro Gly Arg Leu Gln Leu Val Cys His Val Ser Gly Phe Tyr Pro 
        35                  40                  45              


Lys Pro Val Trp Val Met Trp Met Arg Gly Glu Gln Glu Gln Arg Gly 
    50                  55                  60                  


Thr Gln Arg Gly Asp Val Leu Pro Asn Ala Asp Glu Thr Trp Trp Ile 
65                  70                  75                  80  


Phe His Leu Ser His Pro Asp Leu Phe Asp Cys Asp Ser Tyr Pro Gly 
                85                  90                  95      


His Ile Gly Cys Ser 
            100     


<210>  2239
<211>  187
<212>  PRT
<213>  Homo Sapiens

<400>  2239

Met Leu Leu Leu Phe Leu Leu Phe Glu Gly Leu Cys Cys Pro Gly Glu 
1               5                   10                  15      


Asn Thr Ala Val Lys Pro Glu Ala Trp Leu Ser Cys Gly Pro Ser Pro 
            20                  25                  30          


Gly Pro Gly Arg Leu Gln Leu Val Cys His Val Ser Gly Phe Tyr Pro 
        35                  40                  45              


Lys Pro Val Trp Val Met Trp Met Arg Gly Glu Gln Glu Gln Arg Gly 
    50                  55                  60                  


Thr Gln Arg Gly Asp Val Leu Pro Asn Ala Asp Glu Thr Trp Tyr Leu 
65                  70                  75                  80  


Arg Ala Thr Leu Asp Val Ala Ala Gly Glu Ala Ala Gly Leu Ser Cys 
                85                  90                  95      


Arg Val Lys His Ser Ser Leu Gly Gly His Asp Leu Ile Ile His Trp 
            100                 105                 110         


Gly Gly Tyr Ser Ile Phe Leu Ile Leu Ile Cys Leu Thr Val Ile Val 
        115                 120                 125             


Thr Leu Val Ile Leu Val Val Val Asp Ser Arg Leu Lys Lys Gln Ser 
    130                 135                 140                 


Pro Val Phe Leu Met Gly Ala Asn Thr Gln Asp Thr Lys Asn Ser Arg 
145                 150                 155                 160 


His Gln Phe Cys Leu Ala Gln Val Ser Trp Ile Lys Asn Arg Val Leu 
                165                 170                 175     


Lys Lys Trp Lys Thr Arg Leu Asn Gln Leu Trp 
            180                 185         


<210>  2240
<211>  199
<212>  PRT
<213>  Homo Sapiens

<400>  2240

Met Leu Leu Leu Phe Leu Leu Phe Glu Gly Leu Cys Cys Pro Gly Glu 
1               5                   10                  15      


Asn Thr Ala Val Lys Pro Glu Ala Trp Leu Ser Cys Gly Pro Ser Pro 
            20                  25                  30          


Gly Pro Gly Arg Leu Gln Leu Val Cys His Val Ser Gly Phe Tyr Pro 
        35                  40                  45              


Lys Pro Val Trp Val Met Trp Met Arg Gly Glu Gln Glu Gln Arg Gly 
    50                  55                  60                  


Thr Gln Arg Gly Asp Val Leu Pro Asn Ala Asp Glu Thr Trp Tyr Leu 
65                  70                  75                  80  


Arg Ala Thr Leu Asp Val Ala Ala Gly Glu Ala Ala Gly Leu Ser Cys 
                85                  90                  95      


Arg Val Lys His Ser Ser Leu Gly Gly His Asp Leu Ile Ile His Trp 
            100                 105                 110         


Gly Gly Tyr Ser Ile Phe Leu Ile Leu Ile Cys Leu Thr Val Ile Val 
        115                 120                 125             


Thr Leu Val Ile Leu Val Val Val Asp Ser Arg Leu Lys Lys Gln Ser 
    130                 135                 140                 


Ser Asn Lys Asn Ile Leu Ser Pro His Thr Pro Ser Pro Val Phe Leu 
145                 150                 155                 160 


Met Gly Ala Asn Thr Gln Asp Thr Lys Asn Ser Arg His Gln Phe Cys 
                165                 170                 175     


Leu Ala Gln Val Ser Trp Ile Lys Asn Arg Val Leu Lys Lys Trp Lys 
            180                 185                 190         


Thr Arg Leu Asn Gln Leu Trp 
        195                 


<210>  2241
<211>  132
<212>  PRT
<213>  Homo Sapiens

<400>  2241

Met Leu Leu Leu Phe Leu Leu Phe Glu Gly Leu Cys Cys Pro Gly Glu 
1               5                   10                  15      


Asn Thr Ala Val Lys Pro Glu Ala Trp Leu Ser Cys Gly Pro Ser Pro 
            20                  25                  30          


Gly Pro Gly Arg Leu Gln Leu Val Cys His Val Ser Gly Phe Tyr Pro 
        35                  40                  45              


Lys Pro Val Trp Val Met Trp Met Arg Gly Gly Tyr Ser Ile Phe Leu 
    50                  55                  60                  


Ile Leu Ile Cys Leu Thr Val Ile Val Thr Leu Val Ile Leu Val Val 
65                  70                  75                  80  


Val Asp Ser Arg Leu Lys Lys Gln Ser Pro Val Phe Leu Met Gly Ala 
                85                  90                  95      


Asn Thr Gln Asp Thr Lys Asn Ser Arg His Gln Phe Cys Leu Ala Gln 
            100                 105                 110         


Val Ser Trp Ile Lys Asn Arg Val Leu Lys Lys Trp Lys Thr Arg Leu 
        115                 120                 125             


Asn Gln Leu Trp 
    130         


<210>  2242
<211>  144
<212>  PRT
<213>  Homo Sapiens

<400>  2242

Met Leu Leu Leu Phe Leu Leu Phe Glu Gly Leu Cys Cys Pro Gly Glu 
1               5                   10                  15      


Asn Thr Ala Val Lys Pro Glu Ala Trp Leu Ser Cys Gly Pro Ser Pro 
            20                  25                  30          


Gly Pro Gly Arg Leu Gln Leu Val Cys His Val Ser Gly Phe Tyr Pro 
        35                  40                  45              


Lys Pro Val Trp Val Met Trp Met Arg Gly Gly Tyr Ser Ile Phe Leu 
    50                  55                  60                  


Ile Leu Ile Cys Leu Thr Val Ile Val Thr Leu Val Ile Leu Val Val 
65                  70                  75                  80  


Val Asp Ser Arg Leu Lys Lys Gln Ser Ser Asn Lys Asn Ile Leu Ser 
                85                  90                  95      


Pro His Thr Pro Ser Pro Val Phe Leu Met Gly Ala Asn Thr Gln Asp 
            100                 105                 110         


Thr Lys Asn Ser Arg His Gln Phe Cys Leu Ala Gln Val Ser Trp Ile 
        115                 120                 125             


Lys Asn Arg Val Leu Lys Lys Trp Lys Thr Arg Leu Asn Gln Leu Trp 
    130                 135                 140                 


<210>  2243
<211>  60
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2243

Xaa Val Ser Gly Phe Tyr Pro Lys Pro Val Trp Val Met Trp Met Arg 
1               5                   10                  15      


Gly Glu Gln Glu Gln Arg Gly Thr Gln Arg Gly Asp Val Leu Pro Asn 
            20                  25                  30          


Ala Asp Glu Thr Trp Trp Ile Phe His Leu Ser His Pro Asp Leu Phe 
        35                  40                  45              


Asp Cys Asp Ser Tyr Pro Gly His Ile Gly Cys Ser 
    50                  55                  60  


<210>  2244
<211>  351
<212>  PRT
<213>  Homo Sapiens

<400>  2244

Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn 
1               5                   10                  15      


Val Ser Ser Lys Gly Ala Val Ser Lys Glu Ile Thr Asn Ala Leu Glu 
            20                  25                  30          


Thr Trp Gly Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe 
        35                  40                  45              


Gln Met Ser Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Thr Ser Asp 
    50                  55                  60                  


Lys Lys Lys Ile Ala Gln Phe Arg Lys Glu Lys Glu Thr Phe Lys Glu 
65                  70                  75                  80  


Lys Asp Thr Tyr Lys Leu Phe Lys Asn Gly Thr Leu Lys Ile Lys His 
                85                  90                  95      


Leu Lys Thr Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr Asp Thr 
            100                 105                 110         


Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Glu 
        115                 120                 125             


Arg Val Ser Lys Pro Lys Ile Ser Trp Thr Cys Ile Asn Thr Thr Leu 
    130                 135                 140                 


Thr Cys Glu Val Met Asn Gly Thr Asp Pro Glu Leu Asn Leu Tyr Gln 
145                 150                 155                 160 


Asp Gly Lys His Leu Lys Leu Ser Gln Arg Val Ile Thr His Lys Trp 
                165                 170                 175     


Thr Thr Ser Leu Ser Ala Lys Phe Lys Cys Thr Ala Gly Asn Lys Val 
            180                 185                 190         


Ser Lys Glu Ser Ser Val Glu Pro Val Ser Cys Pro Glu Lys Gly Leu 
        195                 200                 205             


Asp Ile Tyr Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met 
    210                 215                 220                 


Val Phe Val Ala Leu Leu Val Phe Tyr Ile Thr Lys Arg Lys Lys Gln 
225                 230                 235                 240 


Arg Ser Arg Arg Asn Asp Glu Glu Leu Glu Thr Arg Ala His Arg Val 
                245                 250                 255     


Ala Thr Glu Glu Arg Gly Arg Lys Pro His Gln Ile Pro Ala Ser Thr 
            260                 265                 270         


Pro Gln Asn Pro Ala Thr Ser Gln His Pro Pro Pro Pro Pro Gly His 
        275                 280                 285             


Arg Ser Gln Ala Pro Ser His Arg Pro Pro Pro Pro Gly His Arg Val 
    290                 295                 300                 


Gln His Gln Pro Gln Lys Arg Pro Pro Ala Pro Ser Gly Thr Gln Val 
305                 310                 315                 320 


His Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro Arg Val Gln Pro Lys 
                325                 330                 335     


Pro Pro His Gly Ala Ala Glu Asn Ser Leu Ser Pro Ser Ser Asn 
            340                 345                 350     


<210>  2245
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  2245

Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn 
1               5                   10                  15      


Val Ser Ser Lys Gly Ala Val Ser Lys Glu Ile Thr Asn Ala Leu Glu 
            20                  25                  30          


Thr Trp Gly Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe 
        35                  40                  45              


Gln Met Ser Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Thr Ser Asp 
    50                  55                  60                  


Lys Lys Lys Ile Ala Gln Phe Arg Lys Glu Lys Glu Thr Phe Lys Glu 
65                  70                  75                  80  


Lys Asp Thr Tyr Lys Leu Phe Lys Asn Gly Thr Leu Lys Ile Lys His 
                85                  90                  95      


Leu Lys Thr Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr Asp Thr 
            100                 105                 110         


Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Gly 
        115                 120                 125             


Lys Cys Ser Phe Pro 
    130             


<210>  2246
<211>  294
<212>  PRT
<213>  Homo Sapiens

<400>  2246

Met Glu Arg Leu Thr Leu Thr Arg Thr Ile Gly Gly Pro Leu Leu Thr 
1               5                   10                  15      


Ala Thr Leu Leu Gly Lys Thr Thr Ile Asn Asp Tyr Gln Val Ile Arg 
            20                  25                  30          


Met Pro Phe Ser His Leu Ser Thr Tyr Ser Leu Val Trp Val Met Ala 
        35                  40                  45              


Ala Val Val Leu Cys Thr Ala Gln Val Gln Val Val Thr Gln Asp Glu 
    50                  55                  60                  


Arg Glu Gln Leu Tyr Thr Pro Ala Ser Leu Lys Cys Ser Leu Gln Asn 
65                  70                  75                  80  


Ala Gln Glu Ala Leu Ile Val Thr Trp Gln Lys Lys Lys Ala Val Ser 
                85                  90                  95      


Pro Glu Asn Met Val Thr Phe Ser Glu Asn His Gly Val Val Ile Gln 
            100                 105                 110         


Pro Ala Tyr Lys Asp Lys Ile Asn Ile Thr Gln Leu Gly Leu Gln Asn 
        115                 120                 125             


Ser Thr Ile Thr Phe Trp Asn Ile Thr Leu Glu Asp Glu Gly Cys Tyr 
    130                 135                 140                 


Met Cys Leu Phe Asn Thr Phe Gly Phe Gly Lys Ile Ser Gly Thr Ala 
145                 150                 155                 160 


Cys Leu Thr Val Tyr Val Gln Pro Ile Val Ser Leu His Tyr Lys Phe 
                165                 170                 175     


Ser Glu Asp His Leu Asn Ile Thr Cys Ser Ala Thr Ala Arg Pro Ala 
            180                 185                 190         


Pro Met Val Phe Trp Lys Val Pro Arg Ser Gly Ile Glu Asn Ser Thr 
        195                 200                 205             


Val Thr Leu Ser His Pro Asn Gly Thr Thr Ser Val Thr Ser Ile Leu 
    210                 215                 220                 


His Ile Lys Asp Pro Lys Asn Gln Val Gly Lys Glu Val Ile Cys Gln 
225                 230                 235                 240 


Val Leu His Leu Gly Thr Val Thr Asp Phe Lys Gln Thr Val Asn Lys 
                245                 250                 255     


Gly Tyr Trp Phe Ser Val Pro Leu Leu Leu Ser Ile Val Ser Leu Val 
            260                 265                 270         


Ile Leu Leu Val Leu Ile Ser Ile Leu Leu Tyr Trp Lys Arg His Arg 
        275                 280                 285             


Asn Gln Asp Arg Glu Pro 
    290                 


<210>  2247
<211>  150
<212>  PRT
<213>  Homo Sapiens

<400>  2247

Met Glu Arg Leu Val Ile Arg Met Pro Phe Ser His Leu Ser Thr Tyr 
1               5                   10                  15      


Ser Leu Val Trp Val Met Ala Ala Val Val Leu Cys Thr Ala Gln Val 
            20                  25                  30          


Gln Val Val Thr Gln Asp Glu Arg Glu Gln Leu Tyr Thr Pro Ala Ser 
        35                  40                  45              


Leu Lys Cys Ser Leu Gln Asn Ala Gln Glu Ala Leu Ile Val Thr Trp 
    50                  55                  60                  


Gln Lys Lys Lys Ala Val Ser Pro Glu Asn Met Val Thr Phe Ser Glu 
65                  70                  75                  80  


Asn His Gly Val Val Ile Gln Pro Ala Tyr Lys Asp Lys Ile Asn Ile 
                85                  90                  95      


Thr Gln Leu Gly Leu Gln Asn Ser Thr Ile Thr Phe Trp Asn Ile Thr 
            100                 105                 110         


Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu Phe Asn Thr Phe Gly Phe 
        115                 120                 125             


Gly Lys Ile Ser Gly Thr Ala Cys Leu Thr Val Tyr Ala His Ser Ile 
    130                 135                 140                 


Pro Ser Leu Gln Ile Leu 
145                 150 


<210>  2248
<211>  269
<212>  PRT
<213>  Homo Sapiens

<400>  2248

Met Glu Arg Leu Val Ile Arg Met Pro Phe Ser His Leu Ser Thr Tyr 
1               5                   10                  15      


Ser Leu Val Trp Val Met Ala Ala Val Val Leu Cys Thr Ala Gln Val 
            20                  25                  30          


Gln Val Val Thr Gln Asp Glu Arg Glu Gln Leu Tyr Thr Pro Ala Ser 
        35                  40                  45              


Leu Lys Cys Ser Leu Gln Asn Ala Gln Glu Ala Leu Ile Val Thr Trp 
    50                  55                  60                  


Gln Lys Lys Lys Ala Val Ser Pro Glu Asn Met Val Thr Phe Ser Glu 
65                  70                  75                  80  


Asn His Gly Val Val Ile Gln Pro Ala Tyr Lys Asp Lys Ile Asn Ile 
                85                  90                  95      


Thr Gln Leu Gly Leu Gln Asn Ser Thr Ile Thr Phe Trp Asn Ile Thr 
            100                 105                 110         


Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu Phe Asn Thr Phe Gly Phe 
        115                 120                 125             


Gly Lys Ile Ser Gly Thr Ala Cys Leu Thr Val Tyr Val Gln Pro Ile 
    130                 135                 140                 


Val Ser Leu His Tyr Lys Phe Ser Glu Asp His Leu Asn Ile Thr Cys 
145                 150                 155                 160 


Ser Ala Thr Ala Arg Pro Ala Pro Met Val Phe Trp Lys Val Pro Arg 
                165                 170                 175     


Ser Gly Ile Glu Asn Ser Thr Val Thr Leu Ser His Pro Asn Gly Thr 
            180                 185                 190         


Thr Ser Val Thr Ser Ile Leu His Ile Lys Asp Pro Lys Asn Gln Val 
        195                 200                 205             


Gly Lys Glu Val Ile Cys Gln Val Leu His Leu Gly Thr Val Thr Asp 
    210                 215                 220                 


Phe Lys Gln Thr Val Asn Lys Gly Tyr Trp Phe Ser Val Pro Leu Leu 
225                 230                 235                 240 


Leu Ser Ile Val Ser Leu Val Ile Leu Leu Val Leu Ile Ser Ile Leu 
                245                 250                 255     


Leu Tyr Trp Lys Arg His Arg Asn Gln Asp Arg Glu Pro 
            260                 265                 


<210>  2249
<211>  202
<212>  PRT
<213>  Homo Sapiens

<400>  2249

Met Lys Val Gln Val Val Thr Gln Asp Glu Arg Glu Gln Leu Tyr Thr 
1               5                   10                  15      


Pro Ala Ser Leu Lys Cys Ser Leu Gln Asn Ala Gln Glu Ala Leu Ile 
            20                  25                  30          


Val Thr Trp Gln Lys Lys Lys Ala Val Ser Pro Glu Asn Met Val Thr 
        35                  40                  45              


Phe Ser Glu Asn His Gly Val Val Ile Gln Pro Ala Tyr Lys Asp Lys 
    50                  55                  60                  


Ile Asn Ile Thr Gln Leu Gly Leu Gln Asn Ser Thr Ile Thr Phe Trp 
65                  70                  75                  80  


Asn Ile Thr Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu Phe Asn Thr 
                85                  90                  95      


Phe Gly Phe Gly Lys Ile Ser Gly Thr Ala Cys Leu Thr Val Tyr Val 
            100                 105                 110         


Gln Pro Ile Val Ser Leu His Tyr Lys Phe Ser Glu Asp His Leu Asn 
        115                 120                 125             


Ile Thr Cys Ser Ala Thr Ala Arg Pro Ala Pro Met Val Phe Trp Lys 
    130                 135                 140                 


Val Pro Arg Ser Gly Ile Glu Asn Ser Thr Val Thr Leu Ser His Pro 
145                 150                 155                 160 


Asn Gly Thr Thr Ser Val Thr Ser Ile Leu His Ile Lys Asp Pro Lys 
                165                 170                 175     


Asn Gln Val Gly Lys Glu Val Ile Cys Gln Val Leu His Leu Gly Thr 
            180                 185                 190         


Val Thr Asp Phe Lys Gln Thr Val Asn Lys 
        195                 200         


<210>  2250
<211>  62
<212>  PRT
<213>  Homo Sapiens

<400>  2250

Met Pro Phe Ser His Leu Ser Thr Tyr Ser Leu Val Trp Val Met Ala 
1               5                   10                  15      


Ala Val Val Leu Cys Thr Ala Gln Val Gln Val Val Thr Gln Asp Glu 
            20                  25                  30          


Arg Glu Gln Leu Tyr Thr Pro Ala Ser Leu Lys Cys Ser Leu Gln Asn 
        35                  40                  45              


Ala Gln Glu Ala Leu Ile Val Thr Trp Gln Lys Lys Lys Ala 
    50                  55                  60          


<210>  2251
<211>  76
<212>  PRT
<213>  Homo Sapiens

<400>  2251

Met Val Thr Phe Ser Glu Asn His Gly Val Val Ile Gln Pro Ala Tyr 
1               5                   10                  15      


Lys Asp Lys Ile Asn Ile Thr Gln Leu Gly Leu Gln Asn Ser Thr Ile 
            20                  25                  30          


Thr Phe Trp Asn Ile Thr Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu 
        35                  40                  45              


Phe Asn Thr Phe Gly Phe Gly Lys Ile Ser Gly Thr Ala Cys Leu Thr 
    50                  55                  60                  


Val Tyr Ala His Ser Ile Pro Ser Leu Gln Ile Leu 
65                  70                  75      


<210>  2252
<211>  195
<212>  PRT
<213>  Homo Sapiens

<400>  2252

Met Val Thr Phe Ser Glu Asn His Gly Val Val Ile Gln Pro Ala Tyr 
1               5                   10                  15      


Lys Asp Lys Ile Asn Ile Thr Gln Leu Gly Leu Gln Asn Ser Thr Ile 
            20                  25                  30          


Thr Phe Trp Asn Ile Thr Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu 
        35                  40                  45              


Phe Asn Thr Phe Gly Phe Gly Lys Ile Ser Gly Thr Ala Cys Leu Thr 
    50                  55                  60                  


Val Tyr Val Gln Pro Ile Val Ser Leu His Tyr Lys Phe Ser Glu Asp 
65                  70                  75                  80  


His Leu Asn Ile Thr Cys Ser Ala Thr Ala Arg Pro Ala Pro Met Val 
                85                  90                  95      


Phe Trp Lys Val Pro Arg Ser Gly Ile Glu Asn Ser Thr Val Thr Leu 
            100                 105                 110         


Ser His Pro Asn Gly Thr Thr Ser Val Thr Ser Ile Leu His Ile Lys 
        115                 120                 125             


Asp Pro Lys Asn Gln Val Gly Lys Glu Val Ile Cys Gln Val Leu His 
    130                 135                 140                 


Leu Gly Thr Val Thr Asp Phe Lys Gln Thr Val Asn Lys Gly Tyr Trp 
145                 150                 155                 160 


Phe Ser Val Pro Leu Leu Leu Ser Ile Val Ser Leu Val Ile Leu Leu 
                165                 170                 175     


Val Leu Ile Ser Ile Leu Leu Tyr Trp Lys Arg His Arg Asn Gln Asp 
            180                 185                 190         


Arg Glu Pro 
        195 


<210>  2253
<211>  165
<212>  PRT
<213>  Homo Sapiens

<400>  2253

Met Leu Cys Pro Trp Arg Thr Ala Asn Leu Gly Leu Leu Leu Ile Leu 
1               5                   10                  15      


Thr Ile Phe Leu Val Ala Ala Ser Ser Ser Leu Cys Met Asp Glu Lys 
            20                  25                  30          


Gln Ile Thr Gln Asn Tyr Ser Lys Val Leu Ala Glu Val Asn Thr Ser 
        35                  40                  45              


Trp Pro Val Lys Met Ala Thr Asn Ala Val Leu Cys Cys Pro Pro Ile 
    50                  55                  60                  


Ala Leu Arg Asn Leu Ile Ile Ile Thr Trp Glu Ile Ile Leu Arg Gly 
65                  70                  75                  80  


Gln Pro Ser Cys Thr Lys Ala Tyr Lys Lys Glu Thr Asn Glu Thr Lys 
                85                  90                  95      


Glu Thr Asn Cys Thr Asp Glu Arg Ile Thr Trp Val Ser Arg Pro Asp 
            100                 105                 110         


Gln Asn Ser Asp Leu Gln Ile Arg Thr Val Ala Ile Thr His Asp Gly 
        115                 120                 125             


Tyr Tyr Arg Cys Ile Met Val Thr Pro Asp Gly Asn Phe His Arg Gly 
    130                 135                 140                 


Tyr His Leu Gln Val Leu Gly Lys Glu His His Ile Leu Arg Tyr Phe 
145                 150                 155                 160 


Thr Ser Pro Asp Leu 
                165 


<210>  2254
<211>  325
<212>  PRT
<213>  Homo Sapiens

<400>  2254

Met Leu Cys Pro Trp Arg Thr Ala Asn Leu Gly Leu Leu Leu Ile Leu 
1               5                   10                  15      


Thr Ile Phe Leu Val Ala Ala Ser Ser Ser Leu Cys Met Asp Glu Lys 
            20                  25                  30          


Gln Ile Thr Gln Asn Tyr Ser Lys Val Leu Ala Glu Val Asn Thr Ser 
        35                  40                  45              


Trp Pro Val Lys Met Ala Thr Asn Ala Val Leu Cys Cys Pro Pro Ile 
    50                  55                  60                  


Ala Leu Arg Asn Leu Ile Ile Ile Thr Trp Glu Ile Ile Leu Arg Gly 
65                  70                  75                  80  


Gln Pro Ser Cys Thr Lys Ala Tyr Lys Lys Glu Thr Asn Glu Thr Lys 
                85                  90                  95      


Glu Thr Asn Cys Thr Asp Glu Arg Ile Thr Trp Val Ser Arg Pro Asp 
            100                 105                 110         


Gln Asn Ser Asp Leu Gln Ile Arg Thr Val Ala Ile Thr His Asp Gly 
        115                 120                 125             


Tyr Tyr Arg Cys Ile Met Val Thr Pro Asp Gly Asn Phe His Arg Gly 
    130                 135                 140                 


Tyr His Leu Gln Val Leu Val Thr Pro Glu Val Thr Leu Phe Gln Asn 
145                 150                 155                 160 


Arg Asn Arg Thr Ala Val Cys Lys Ala Val Ala Gly Lys Pro Ala Ala 
                165                 170                 175     


His Ile Ser Trp Ile Pro Glu Gly Asp Cys Ala Thr Lys Gln Glu Tyr 
            180                 185                 190         


Trp Ser Asn Gly Thr Val Thr Val Lys Ser Thr Cys His Trp Glu Val 
        195                 200                 205             


His Asn Val Ser Thr Val Thr Cys His Val Ser His Leu Thr Gly Asn 
    210                 215                 220                 


Lys Ser Leu Tyr Ile Glu Leu Leu Pro Val Pro Gly Ala Lys Lys Ser 
225                 230                 235                 240 


Ala Lys Leu Tyr Ile Pro Tyr Ile Ile Leu Thr Ile Ile Ile Leu Thr 
                245                 250                 255     


Ile Val Gly Phe Ile Trp Leu Leu Lys Val Asn Gly Cys Arg Lys Tyr 
            260                 265                 270         


Lys Leu Asn Lys Thr Glu Ser Thr Pro Val Val Glu Glu Asp Glu Met 
        275                 280                 285             


Gln Pro Tyr Ala Ser Tyr Thr Glu Lys Asn Asn Pro Leu Tyr Asp Thr 
    290                 295                 300                 


Thr Asn Lys Val Lys Ala Ser Glu Ala Leu Gln Ser Glu Val Asp Thr 
305                 310                 315                 320 


Asp Leu His Thr Leu 
                325 


<210>  2255
<211>  188
<212>  PRT
<213>  Homo Sapiens

<400>  2255

Met Leu Cys Pro Trp Arg Thr Ala Asn Leu Gly Leu Leu Leu Ile Leu 
1               5                   10                  15      


Thr Ile Phe Leu Val Ala Glu Ala Glu Gly Ala Ala Gln Pro Asn Asn 
            20                  25                  30          


Ser Leu Met Leu Gln Thr Ser Lys Glu Asn His Ala Leu Ala Ser Ser 
        35                  40                  45              


Ser Leu Cys Met Asp Glu Lys Gln Ile Thr Gln Asn Tyr Ser Lys Val 
    50                  55                  60                  


Leu Ala Glu Val Asn Thr Ser Trp Pro Val Lys Met Ala Thr Asn Ala 
65                  70                  75                  80  


Val Leu Cys Cys Pro Pro Ile Ala Leu Arg Asn Leu Ile Ile Ile Thr 
                85                  90                  95      


Trp Glu Ile Ile Leu Arg Gly Gln Pro Ser Cys Thr Lys Ala Tyr Lys 
            100                 105                 110         


Lys Glu Thr Asn Glu Thr Lys Glu Thr Asn Cys Thr Asp Glu Arg Ile 
        115                 120                 125             


Thr Trp Val Ser Arg Pro Asp Gln Asn Ser Asp Leu Gln Ile Arg Thr 
    130                 135                 140                 


Val Ala Ile Thr His Asp Gly Tyr Tyr Arg Cys Ile Met Val Thr Pro 
145                 150                 155                 160 


Asp Gly Asn Phe His Arg Gly Tyr His Leu Gln Val Leu Gly Lys Glu 
                165                 170                 175     


His His Ile Leu Arg Tyr Phe Thr Ser Pro Asp Leu 
            180                 185             


<210>  2256
<211>  348
<212>  PRT
<213>  Homo Sapiens

<400>  2256

Met Leu Cys Pro Trp Arg Thr Ala Asn Leu Gly Leu Leu Leu Ile Leu 
1               5                   10                  15      


Thr Ile Phe Leu Val Ala Glu Ala Glu Gly Ala Ala Gln Pro Asn Asn 
            20                  25                  30          


Ser Leu Met Leu Gln Thr Ser Lys Glu Asn His Ala Leu Ala Ser Ser 
        35                  40                  45              


Ser Leu Cys Met Asp Glu Lys Gln Ile Thr Gln Asn Tyr Ser Lys Val 
    50                  55                  60                  


Leu Ala Glu Val Asn Thr Ser Trp Pro Val Lys Met Ala Thr Asn Ala 
65                  70                  75                  80  


Val Leu Cys Cys Pro Pro Ile Ala Leu Arg Asn Leu Ile Ile Ile Thr 
                85                  90                  95      


Trp Glu Ile Ile Leu Arg Gly Gln Pro Ser Cys Thr Lys Ala Tyr Lys 
            100                 105                 110         


Lys Glu Thr Asn Glu Thr Lys Glu Thr Asn Cys Thr Asp Glu Arg Ile 
        115                 120                 125             


Thr Trp Val Ser Arg Pro Asp Gln Asn Ser Asp Leu Gln Ile Arg Thr 
    130                 135                 140                 


Val Ala Ile Thr His Asp Gly Tyr Tyr Arg Cys Ile Met Val Thr Pro 
145                 150                 155                 160 


Asp Gly Asn Phe His Arg Gly Tyr His Leu Gln Val Leu Val Thr Pro 
                165                 170                 175     


Glu Val Thr Leu Phe Gln Asn Arg Asn Arg Thr Ala Val Cys Lys Ala 
            180                 185                 190         


Val Ala Gly Lys Pro Ala Ala His Ile Ser Trp Ile Pro Glu Gly Asp 
        195                 200                 205             


Cys Ala Thr Lys Gln Glu Tyr Trp Ser Asn Gly Thr Val Thr Val Lys 
    210                 215                 220                 


Ser Thr Cys His Trp Glu Val His Asn Val Ser Thr Val Thr Cys His 
225                 230                 235                 240 


Val Ser His Leu Thr Gly Asn Lys Ser Leu Tyr Ile Glu Leu Leu Pro 
                245                 250                 255     


Val Pro Gly Ala Lys Lys Ser Ala Lys Leu Tyr Ile Pro Tyr Ile Ile 
            260                 265                 270         


Leu Thr Ile Ile Ile Leu Thr Ile Val Gly Phe Ile Trp Leu Leu Lys 
        275                 280                 285             


Val Asn Gly Cys Arg Lys Tyr Lys Leu Asn Lys Thr Glu Ser Thr Pro 
    290                 295                 300                 


Val Val Glu Glu Asp Glu Met Gln Pro Tyr Ala Ser Tyr Thr Glu Lys 
305                 310                 315                 320 


Asn Asn Pro Leu Tyr Asp Thr Thr Asn Lys Val Lys Ala Ser Glu Ala 
                325                 330                 335     


Leu Gln Ser Glu Val Asp Thr Asp Leu His Thr Leu 
            340                 345             


<210>  2257
<211>  212
<212>  PRT
<213>  Homo Sapiens

<400>  2257

Met Leu Cys Pro Trp Arg Thr Ala Asn Leu Gly Leu Leu Leu Ile Leu 
1               5                   10                  15      


Thr Ile Phe Leu Val Ala Val Asn Thr Ser Trp Pro Val Lys Met Ala 
            20                  25                  30          


Thr Asn Ala Val Leu Cys Cys Pro Pro Ile Ala Leu Arg Asn Leu Ile 
        35                  40                  45              


Ile Ile Thr Trp Glu Ile Ile Leu Arg Gly Gln Pro Ser Cys Thr Lys 
    50                  55                  60                  


Ala Tyr Lys Lys Glu Thr Asn Glu Thr Lys Glu Thr Asn Cys Thr Asp 
65                  70                  75                  80  


Glu Arg Ile Thr Trp Val Ser Arg Pro Asp Gln Asn Ser Asp Leu Gln 
                85                  90                  95      


Ile Arg Thr Val Ala Ile Thr His Asp Gly Tyr Tyr Arg Cys Ile Met 
            100                 105                 110         


Val Thr Pro Asp Gly Asn Phe His Arg Gly Tyr His Leu Gln Val Leu 
        115                 120                 125             


Val Thr Pro Glu Val Thr Leu Phe Gln Asn Arg Asn Arg Thr Ala Val 
    130                 135                 140                 


Cys Lys Ala Val Ala Gly Lys Pro Ala Ala His Ile Ser Trp Ile Pro 
145                 150                 155                 160 


Glu Gly Asp Cys Ala Thr Lys Gln Glu Tyr Trp Ser Asn Gly Thr Val 
                165                 170                 175     


Thr Val Lys Ser Thr Cys His Trp Glu Val His Asn Val Ser Thr Val 
            180                 185                 190         


Thr Cys His Val Ser His Leu Thr Gly Asn Lys Ser Leu Tyr Ile Glu 
        195                 200                 205             


Leu Leu Pro Gly 
    210         


<210>  2258
<211>  153
<212>  PRT
<213>  Homo Sapiens

<400>  2258

His Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu 
1               5                   10                  15      


Thr Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln 
            20                  25                  30          


Trp Leu Leu Glu Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr 
        35                  40                  45              


Ser Leu Thr Ile Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser 
    50                  55                  60                  


Pro Gln Trp Ser His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp 
65                  70                  75                  80  


Ala Asp Gly Lys Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys 
                85                  90                  95      


Arg Glu Ser Pro Arg His Ala Cys Gly Lys Gly Lys Val Cys Val Thr 
            100                 105                 110         


Phe Ser Pro Ala Pro Gln Gly Ala Cys Thr Gln Gly Arg Gly Lys Pro 
        115                 120                 125             


Ala Gln Thr Ala Ala Ser Ser Ser Pro Gly His Ala Ala Leu Ser Ala 
    130                 135                 140                 


Leu Val Phe Arg Glu Lys Asp Leu Leu 
145                 150             


<210>  2259
<211>  159
<212>  PRT
<213>  Homo Sapiens

<400>  2259

Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Glu Tyr Leu Ala Phe 
1               5                   10                  15      


Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu Tyr Ala 
            20                  25                  30          


Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala Leu Asp 
        35                  40                  45              


Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr Asn Lys 
    50                  55                  60                  


Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr Lys Asp 
65                  70                  75                  80  


Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly Asp Lys 
                85                  90                  95      


Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn Asp Ser 
            100                 105                 110         


Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp Met Glu 
        115                 120                 125             


Arg Ile His Leu Asn Val Ser Asp Pro Pro Lys Lys Val Thr Thr Val 
    130                 135                 140                 


Ile Gln Asn Pro Met Pro Ile Arg Glu Gly Asp Thr Val Thr Leu 
145                 150                 155                 


<210>  2260
<211>  138
<212>  PRT
<213>  Homo Sapiens

<400>  2260

Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Glu Tyr Leu Ala Phe 
1               5                   10                  15      


Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu Tyr Ala 
            20                  25                  30          


Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala Leu Asp 
        35                  40                  45              


Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr Asn Lys 
    50                  55                  60                  


Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr Lys Asp 
65                  70                  75                  80  


Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly Asp Lys 
                85                  90                  95      


Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn Asp Ser 
            100                 105                 110         


Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp Met Glu 
        115                 120                 125             


Arg Ile His Leu Asn Val Ser Glu Arg Pro 
    130                 135             


<210>  2261
<211>  145
<212>  PRT
<213>  Homo Sapiens

<400>  2261

Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Glu Tyr Leu Ala Phe 
1               5                   10                  15      


Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu Tyr Ala 
            20                  25                  30          


Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala Leu Asp 
        35                  40                  45              


Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr Asn Lys 
    50                  55                  60                  


Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr Lys Asp 
65                  70                  75                  80  


Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly Asp Lys 
                85                  90                  95      


Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn Asp Ser 
            100                 105                 110         


Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp Met Glu 
        115                 120                 125             


Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His Ile Gln 
    130                 135                 140                 


Leu 
145 


<210>  2262
<211>  191
<212>  PRT
<213>  Homo Sapiens

<400>  2262

Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Glu Tyr Leu Ala Phe 
1               5                   10                  15      


Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu Tyr Ala 
            20                  25                  30          


Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala Leu Asp 
        35                  40                  45              


Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr Asn Lys 
    50                  55                  60                  


Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr Lys Asp 
65                  70                  75                  80  


Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly Asp Lys 
                85                  90                  95      


Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn Asp Ser 
            100                 105                 110         


Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp Met Glu 
        115                 120                 125             


Arg Ile His Leu Asn Val Ser Val Ala Pro Arg Gly Gly Ser Asn Glu 
    130                 135                 140                 


Ala Gly Cys Cys His Leu Asp Leu Leu Asp His Gln Val Cys Leu His 
145                 150                 155                 160 


Pro Glu Arg Ala Gln Val Leu Pro Thr Val Glu Ser Pro Trp Glu Asp 
                165                 170                 175     


Cys Asp Leu Pro Ala Ser Gly Cys Arg Trp Glu Val Pro Leu Gln 
            180                 185                 190     


<210>  2263
<211>  106
<212>  PRT
<213>  Homo Sapiens

<400>  2263

Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu 
1               5                   10                  15      


Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu 
            20                  25                  30          


Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala 
        35                  40                  45              


Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr 
    50                  55                  60                  


Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr 
65                  70                  75                  80  


Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly 
                85                  90                  95      


Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile 
            100                 105     


<210>  2264
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  2264

Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu 
1               5                   10                  15      


Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu 
            20                  25                  30          


Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala 
        35                  40                  45              


Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr 
    50                  55                  60                  


Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr 
65                  70                  75                  80  


Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly 
                85                  90                  95      


Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn 
            100                 105                 110         


Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp 
        115                 120                 125             


Met Glu Arg Ile His 
    130             


<210>  2265
<211>  164
<212>  PRT
<213>  Homo Sapiens

<400>  2265

Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu 
1               5                   10                  15      


Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu 
            20                  25                  30          


Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala 
        35                  40                  45              


Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr 
    50                  55                  60                  


Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr 
65                  70                  75                  80  


Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly 
                85                  90                  95      


Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn 
            100                 105                 110         


Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp 
        115                 120                 125             


Met Glu Arg Ile His Leu Asn Val Ser Asp Pro Pro Lys Lys Val Thr 
    130                 135                 140                 


Thr Val Ile Gln Asn Pro Met Pro Ile Arg Glu Gly Asp Thr Val Thr 
145                 150                 155                 160 


Leu Ser Cys Asn 
                


<210>  2266
<211>  226
<212>  PRT
<213>  Homo Sapiens

<400>  2266

Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu 
1               5                   10                  15      


Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu 
            20                  25                  30          


Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala 
        35                  40                  45              


Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr 
    50                  55                  60                  


Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr 
65                  70                  75                  80  


Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly 
                85                  90                  95      


Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn 
            100                 105                 110         


Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp 
        115                 120                 125             


Met Glu Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His 
    130                 135                 140                 


Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu Thr 
145                 150                 155                 160 


Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln Trp 
                165                 170                 175     


Leu Leu Glu Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr Ser 
            180                 185                 190         


Leu Thr Ile Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser Pro 
        195                 200                 205             


Gln Trp Ser His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp Ala 
    210                 215                 220                 


Asp Gly 
225     


<210>  2267
<211>  670
<212>  PRT
<213>  Homo Sapiens

<400>  2267

Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu 
1               5                   10                  15      


Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu 
            20                  25                  30          


Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala 
        35                  40                  45              


Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr 
    50                  55                  60                  


Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr 
65                  70                  75                  80  


Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly 
                85                  90                  95      


Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn 
            100                 105                 110         


Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp 
        115                 120                 125             


Met Glu Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His 
    130                 135                 140                 


Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu Thr 
145                 150                 155                 160 


Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln Trp 
                165                 170                 175     


Leu Leu Glu Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr Ser 
            180                 185                 190         


Leu Thr Ile Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser Pro 
        195                 200                 205             


Gln Trp Ser His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp Ala 
    210                 215                 220                 


Asp Gly Lys Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys His 
225                 230                 235                 240 


Pro Pro Lys Lys Val Thr Thr Val Ile Gln Asn Pro Met Pro Ile Arg 
                245                 250                 255     


Glu Gly Asp Thr Val Thr Leu Ser Cys Asn Tyr Asn Ser Ser Asn Pro 
            260                 265                 270         


Ser Val Thr Arg Tyr Glu Trp Lys Pro His Gly Ala Trp Glu Glu Pro 
        275                 280                 285             


Ser Leu Gly Val Leu Lys Ile Gln Asn Val Gly Trp Asp Asn Thr Thr 
    290                 295                 300                 


Ile Ala Cys Ala Ala Cys Asn Ser Trp Cys Ser Trp Ala Ser Pro Val 
305                 310                 315                 320 


Ala Leu Asn Val Gln Tyr Ala Pro Arg Asp Val Arg Val Arg Lys Ile 
                325                 330                 335     


Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser Val Ser Leu Gln Cys 
            340                 345                 350         


Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln Phe Phe Trp Glu Lys 
        355                 360                 365             


Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu Asn Phe Asp Ser Ile 
    370                 375                 380                 


Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val Asn Asn Ser Ile 
385                 390                 395                 400 


Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu Val Leu Tyr Ala Pro 
                405                 410                 415     


Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp Gln Val Met Glu Gly 
            420                 425                 430         


Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala Asn Pro Pro Val Ser 
        435                 440                 445             


His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser Leu Pro Tyr His Ser 
    450                 455                 460                 


Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln His Ser Gly Ala Tyr 
465                 470                 475                 480 


Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly Arg Ser Pro Leu Ser 
                485                 490                 495     


Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Ile Gly Arg Arg Val Ala 
            500                 505                 510         


Val Gly Leu Gly Ser Cys Leu Ala Ile Leu Ile Leu Ala Ile Cys Gly 
        515                 520                 525             


Leu Lys Leu Gln Arg Arg Trp Lys Arg Thr Gln Ser Gln Gln Gly Leu 
    530                 535                 540                 


Gln Glu Asn Ser Ser Gly Gln Ser Phe Phe Val Arg Asn Lys Lys Val 
545                 550                 555                 560 


Arg Arg Ala Pro Leu Ser Glu Gly Pro His Ser Leu Gly Cys Tyr Asn 
                565                 570                 575     


Pro Met Met Glu Asp Gly Ile Ser Tyr Thr Thr Leu Arg Phe Pro Glu 
            580                 585                 590         


Met Asn Ile Pro Arg Thr Gly Asp Ala Glu Ser Ser Glu Met Gln Arg 
        595                 600                 605             


Pro Pro Pro Asp Cys Asp Asp Thr Val Thr Tyr Ser Ala Leu His Lys 
    610                 615                 620                 


Arg Gln Val Gly Asp Tyr Glu Asn Val Ile Pro Asp Phe Pro Glu Asp 
625                 630                 635                 640 


Glu Gly Ile His Tyr Ser Glu Leu Ile Gln Phe Gly Val Gly Glu Arg 
                645                 650                 655     


Pro Gln Ala Gln Glu Asn Val Asp Tyr Val Ile Leu Lys His 
            660                 665                 670 


<210>  2268
<211>  670
<212>  PRT
<213>  Homo Sapiens

<400>  2268

Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu 
1               5                   10                  15      


Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu 
            20                  25                  30          


Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala 
        35                  40                  45              


Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr 
    50                  55                  60                  


Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr 
65                  70                  75                  80  


Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly 
                85                  90                  95      


Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn 
            100                 105                 110         


Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp 
        115                 120                 125             


Met Glu Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His 
    130                 135                 140                 


Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu Thr 
145                 150                 155                 160 


Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln Trp 
                165                 170                 175     


Leu Leu Glu Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr Ser 
            180                 185                 190         


Leu Thr Ile Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser Pro 
        195                 200                 205             


Gln Trp Ser His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp Ala 
    210                 215                 220                 


Asp Gly Lys Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys His 
225                 230                 235                 240 


Pro Pro Lys Lys Val Thr Thr Val Ile Gln Asn Pro Met Pro Ile Arg 
                245                 250                 255     


Glu Gly Asp Thr Val Thr Leu Ser Cys Asn Tyr Asn Ser Ser Asn Pro 
            260                 265                 270         


Ser Val Thr Arg Tyr Glu Trp Lys Pro His Gly Ala Trp Glu Glu Pro 
        275                 280                 285             


Ser Leu Gly Val Leu Lys Ile Gln Asn Val Gly Trp Asp Asn Thr Thr 
    290                 295                 300                 


Ile Ala Cys Ala Ala Cys Asn Ser Trp Cys Ser Trp Ala Ser Pro Val 
305                 310                 315                 320 


Ala Leu Asn Val Gln Tyr Ala Pro Arg Asp Val Arg Val Arg Lys Ile 
                325                 330                 335     


Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser Val Ser Leu Gln Cys 
            340                 345                 350         


Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln Phe Phe Trp Glu Lys 
        355                 360                 365             


Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu Asn Phe Asp Ser Ile 
    370                 375                 380                 


Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val Asn Asn Ser Ile 
385                 390                 395                 400 


Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu Val Leu Tyr Ala Pro 
                405                 410                 415     


Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp Gln Val Met Glu Gly 
            420                 425                 430         


Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala Asn Pro Pro Val Ser 
        435                 440                 445             


His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser Leu Pro Tyr His Ser 
    450                 455                 460                 


Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln His Ser Gly Ala Tyr 
465                 470                 475                 480 


Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly Arg Ser Pro Leu Ser 
                485                 490                 495     


Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Ile Gly Arg Arg Val Ala 
            500                 505                 510         


Val Gly Leu Gly Ser Cys Leu Ala Ile Leu Ile Leu Ala Ile Cys Gly 
        515                 520                 525             


Leu Lys Leu Gln Arg Arg Trp Lys Arg Thr Gln Ser Gln Gln Gly Leu 
    530                 535                 540                 


Gln Glu Asn Ser Ser Gly Gln Ser Phe Phe Val Arg Asn Lys Lys Val 
545                 550                 555                 560 


Arg Arg Ala Pro Leu Ser Glu Gly Pro His Ser Leu Gly Cys Tyr Asn 
                565                 570                 575     


Pro Met Met Glu Asp Gly Ile Ser Tyr Thr Thr Leu Arg Phe Pro Glu 
            580                 585                 590         


Met Asn Ile Pro Arg Thr Gly Asp Ala Glu Ser Ser Glu Met Gln Arg 
        595                 600                 605             


Pro Pro Pro Asp Cys Asp Asp Thr Val Thr Tyr Ser Ala Leu His Lys 
    610                 615                 620                 


Arg Gln Val Gly Asp Tyr Glu Asn Val Ile Pro Asp Phe Pro Glu Asp 
625                 630                 635                 640 


Glu Gly Ile His Tyr Ser Glu Leu Ile Gln Phe Gly Val Gly Glu Arg 
                645                 650                 655     


Pro Gln Ala Gln Glu Asn Val Asp Tyr Val Ile Leu Lys His 
            660                 665                 670 


<210>  2269
<211>  847
<212>  PRT
<213>  Homo Sapiens

<400>  2269

Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu 
1               5                   10                  15      


Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu 
            20                  25                  30          


Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala 
        35                  40                  45              


Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr 
    50                  55                  60                  


Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr 
65                  70                  75                  80  


Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly 
                85                  90                  95      


Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn 
            100                 105                 110         


Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp 
        115                 120                 125             


Met Glu Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His 
    130                 135                 140                 


Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu Thr 
145                 150                 155                 160 


Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln Trp 
                165                 170                 175     


Leu Leu Glu Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr Ser 
            180                 185                 190         


Leu Thr Ile Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser Pro 
        195                 200                 205             


Gln Trp Ser His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp Ala 
    210                 215                 220                 


Asp Gly Lys Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys His 
225                 230                 235                 240 


Thr Pro Lys Leu Glu Ile Lys Val Thr Pro Ser Asp Ala Ile Val Arg 
                245                 250                 255     


Glu Gly Asp Ser Val Thr Met Thr Cys Glu Val Ser Ser Ser Asn Pro 
            260                 265                 270         


Glu Tyr Thr Thr Val Ser Trp Leu Lys Asp Gly Thr Ser Leu Lys Lys 
        275                 280                 285             


Gln Asn Thr Phe Thr Leu Asn Leu Arg Glu Val Thr Lys Asp Gln Ser 
    290                 295                 300                 


Gly Lys Tyr Cys Cys Gln Val Ser Asn Asp Val Gly Pro Gly Arg Ser 
305                 310                 315                 320 


Glu Glu Val Phe Leu Gln Val Gln Tyr Ala Pro Glu Pro Ser Thr Val 
                325                 330                 335     


Gln Ile Leu His Ser Pro Ala Val Glu Gly Ser Gln Val Glu Phe Leu 
            340                 345                 350         


Cys Met Ser Leu Ala Asn Pro Leu Pro Thr Asn Tyr Thr Trp Tyr His 
        355                 360                 365             


Asn Gly Lys Glu Met Gln Gly Arg Thr Glu Glu Lys Val His Ile Pro 
    370                 375                 380                 


Lys Ile Leu Pro Trp His Ala Gly Thr Tyr Ser Cys Val Ala Glu Asn 
385                 390                 395                 400 


Ile Leu Gly Thr Gly Gln Arg Gly Pro Gly Ala Glu Leu Asp Val Gln 
                405                 410                 415     


Tyr Pro Pro Lys Lys Val Thr Thr Val Ile Gln Asn Pro Met Pro Ile 
            420                 425                 430         


Arg Glu Gly Asp Thr Val Thr Leu Ser Cys Asn Tyr Asn Ser Ser Asn 
        435                 440                 445             


Pro Ser Val Thr Arg Tyr Glu Trp Lys Pro His Gly Ala Trp Glu Glu 
    450                 455                 460                 


Pro Ser Leu Gly Val Leu Lys Ile Gln Asn Val Gly Trp Asp Asn Thr 
465                 470                 475                 480 


Thr Ile Ala Cys Ala Ala Cys Asn Ser Trp Cys Ser Trp Ala Ser Pro 
                485                 490                 495     


Val Ala Leu Asn Val Gln Tyr Ala Pro Arg Asp Val Arg Val Arg Lys 
            500                 505                 510         


Ile Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser Val Ser Leu Gln 
        515                 520                 525             


Cys Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln Phe Phe Trp Glu 
    530                 535                 540                 


Lys Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu Asn Phe Asp Ser 
545                 550                 555                 560 


Ile Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val Asn Asn Ser 
                565                 570                 575     


Ile Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu Val Leu Tyr Ala 
            580                 585                 590         


Pro Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp Gln Val Met Glu 
        595                 600                 605             


Gly Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala Asn Pro Pro Val 
    610                 615                 620                 


Ser His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser Leu Pro Tyr His 
625                 630                 635                 640 


Ser Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln His Ser Gly Ala 
                645                 650                 655     


Tyr Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly Arg Ser Pro Leu 
            660                 665                 670         


Ser Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Ile Gly Arg Arg Val 
        675                 680                 685             


Ala Val Gly Leu Gly Ser Cys Leu Ala Ile Leu Ile Leu Ala Ile Cys 
    690                 695                 700                 


Gly Leu Lys Leu Gln Arg Arg Trp Lys Arg Thr Gln Ser Gln Gln Gly 
705                 710                 715                 720 


Leu Gln Glu Asn Ser Ser Gly Gln Ser Phe Phe Val Arg Asn Lys Lys 
                725                 730                 735     


Val Arg Arg Ala Pro Leu Ser Glu Gly Pro His Ser Leu Gly Cys Tyr 
            740                 745                 750         


Asn Pro Met Met Glu Asp Gly Ile Ser Tyr Thr Thr Leu Arg Phe Pro 
        755                 760                 765             


Glu Met Asn Ile Pro Arg Thr Gly Asp Ala Glu Ser Ser Glu Met Gln 
    770                 775                 780                 


Arg Pro Pro Pro Asp Cys Asp Asp Thr Val Thr Tyr Ser Ala Leu His 
785                 790                 795                 800 


Lys Arg Gln Val Gly Asp Tyr Glu Asn Val Ile Pro Asp Phe Pro Glu 
                805                 810                 815     


Asp Glu Gly Ile His Tyr Ser Glu Leu Ile Gln Phe Gly Val Gly Glu 
            820                 825                 830         


Arg Pro Gln Ala Gln Glu Asn Val Asp Tyr Val Ile Leu Lys His 
        835                 840                 845         


<210>  2270
<211>  759
<212>  PRT
<213>  Homo Sapiens

<400>  2270

Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu 
1               5                   10                  15      


Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu 
            20                  25                  30          


Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala 
        35                  40                  45              


Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr 
    50                  55                  60                  


Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr 
65                  70                  75                  80  


Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly 
                85                  90                  95      


Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn 
            100                 105                 110         


Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp 
        115                 120                 125             


Met Glu Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His 
    130                 135                 140                 


Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu Thr 
145                 150                 155                 160 


Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln Trp 
                165                 170                 175     


Leu Leu Glu Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr Ser 
            180                 185                 190         


Leu Thr Ile Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser Pro 
        195                 200                 205             


Gln Trp Ser His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp Ala 
    210                 215                 220                 


Asp Gly Lys Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys His 
225                 230                 235                 240 


Thr Pro Lys Leu Glu Ile Lys Val Thr Pro Ser Asp Ala Ile Val Arg 
                245                 250                 255     


Glu Gly Asp Ser Val Thr Met Thr Cys Glu Val Ser Ser Ser Asn Pro 
            260                 265                 270         


Glu Tyr Thr Thr Val Ser Trp Leu Lys Asp Gly Thr Ser Leu Lys Lys 
        275                 280                 285             


Gln Asn Thr Phe Thr Leu Asn Leu Arg Glu Val Thr Lys Asp Gln Ser 
    290                 295                 300                 


Gly Lys Tyr Cys Cys Gln Val Ser Asn Asp Val Gly Pro Gly Arg Ser 
305                 310                 315                 320 


Glu Glu Val Phe Leu Gln Val Gln Tyr Pro Pro Lys Lys Val Thr Thr 
                325                 330                 335     


Val Ile Gln Asn Pro Met Pro Ile Arg Glu Gly Asp Thr Val Thr Leu 
            340                 345                 350         


Ser Cys Asn Tyr Asn Ser Ser Asn Pro Ser Val Thr Arg Tyr Glu Trp 
        355                 360                 365             


Lys Pro His Gly Ala Trp Glu Glu Pro Ser Leu Gly Val Leu Lys Ile 
    370                 375                 380                 


Gln Asn Val Gly Trp Asp Asn Thr Thr Ile Ala Cys Ala Ala Cys Asn 
385                 390                 395                 400 


Ser Trp Cys Ser Trp Ala Ser Pro Val Ala Leu Asn Val Gln Tyr Ala 
                405                 410                 415     


Pro Arg Asp Val Arg Val Arg Lys Ile Lys Pro Leu Ser Glu Ile His 
            420                 425                 430         


Ser Gly Asn Ser Val Ser Leu Gln Cys Asp Phe Ser Ser Ser His Pro 
        435                 440                 445             


Lys Glu Val Gln Phe Phe Trp Glu Lys Asn Gly Arg Leu Leu Gly Lys 
    450                 455                 460                 


Glu Ser Gln Leu Asn Phe Asp Ser Ile Ser Pro Glu Asp Ala Gly Ser 
465                 470                 475                 480 


Tyr Ser Cys Trp Val Asn Asn Ser Ile Gly Gln Thr Ala Ser Lys Ala 
                485                 490                 495     


Trp Thr Leu Glu Val Leu Tyr Ala Pro Arg Arg Leu Arg Val Ser Met 
            500                 505                 510         


Ser Pro Gly Asp Gln Val Met Glu Gly Lys Ser Ala Thr Leu Thr Cys 
        515                 520                 525             


Glu Ser Asp Ala Asn Pro Pro Val Ser His Tyr Thr Trp Phe Asp Trp 
    530                 535                 540                 


Asn Asn Gln Ser Leu Pro Tyr His Ser Gln Lys Leu Arg Leu Glu Pro 
545                 550                 555                 560 


Val Lys Val Gln His Ser Gly Ala Tyr Trp Cys Gln Gly Thr Asn Ser 
                565                 570                 575     


Val Gly Lys Gly Arg Ser Pro Leu Ser Thr Leu Thr Val Tyr Tyr Ser 
            580                 585                 590         


Pro Glu Thr Ile Gly Arg Arg Val Ala Val Gly Leu Gly Ser Cys Leu 
        595                 600                 605             


Ala Ile Leu Ile Leu Ala Ile Cys Gly Leu Lys Leu Gln Arg Arg Trp 
    610                 615                 620                 


Lys Arg Thr Gln Ser Gln Gln Gly Leu Gln Glu Asn Ser Ser Gly Gln 
625                 630                 635                 640 


Ser Phe Phe Val Arg Asn Lys Lys Val Arg Arg Ala Pro Leu Ser Glu 
                645                 650                 655     


Gly Pro His Ser Leu Gly Cys Tyr Asn Pro Met Met Glu Asp Gly Ile 
            660                 665                 670         


Ser Tyr Thr Thr Leu Arg Phe Pro Glu Met Asn Ile Pro Arg Thr Gly 
        675                 680                 685             


Asp Ala Glu Ser Ser Glu Met Gln Arg Pro Pro Pro Asp Cys Asp Asp 
    690                 695                 700                 


Thr Val Thr Tyr Ser Ala Leu His Lys Arg Gln Val Gly Asp Tyr Glu 
705                 710                 715                 720 


Asn Val Ile Pro Asp Phe Pro Glu Asp Glu Gly Ile His Tyr Ser Glu 
                725                 730                 735     


Leu Ile Gln Phe Gly Val Gly Glu Arg Pro Gln Ala Gln Glu Asn Val 
            740                 745                 750         


Asp Tyr Val Ile Leu Lys His 
        755                 


<210>  2271
<211>  751
<212>  PRT
<213>  Homo Sapiens

<400>  2271

Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu 
1               5                   10                  15      


Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu 
            20                  25                  30          


Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala 
        35                  40                  45              


Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr 
    50                  55                  60                  


Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr 
65                  70                  75                  80  


Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly 
                85                  90                  95      


Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn 
            100                 105                 110         


Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp 
        115                 120                 125             


Met Glu Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His 
    130                 135                 140                 


Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu Thr 
145                 150                 155                 160 


Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln Trp 
                165                 170                 175     


Leu Leu Glu Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr Ser 
            180                 185                 190         


Leu Thr Ile Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser Pro 
        195                 200                 205             


Gln Trp Ser His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp Ala 
    210                 215                 220                 


Asp Gly Lys Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys His 
225                 230                 235                 240 


Thr Pro Lys Leu Glu Ile Lys Val Thr Pro Ser Asp Ala Ile Val Arg 
                245                 250                 255     


Glu Gly Asp Ser Val Thr Met Thr Cys Glu Val Ser Ser Ser Asn Pro 
            260                 265                 270         


Glu Tyr Thr Thr Val Ser Trp Leu Lys Asp Gly Thr Ser Leu Lys Lys 
        275                 280                 285             


Gln Asn Thr Phe Thr Leu Asn Leu Arg Glu Val Thr Lys Asp Gln Ser 
    290                 295                 300                 


Gly Lys Tyr Cys Cys Gln Val Ser Asn Asp Val Gly Pro Gly Arg Ser 
305                 310                 315                 320 


Glu Glu Val Phe Leu Gln Val Gln Tyr Ala Pro Glu Pro Ser Thr Val 
                325                 330                 335     


Gln Ile Leu His Ser Pro Ala Val Glu Gly Ser Gln Val Glu Phe Leu 
            340                 345                 350         


Cys Met Ser Leu Ala Asn Pro Leu Pro Thr Asn Tyr Thr Trp Tyr His 
        355                 360                 365             


Asn Gly Lys Glu Met Gln Gly Arg Thr Glu Glu Lys Val His Ile Pro 
    370                 375                 380                 


Lys Ile Leu Pro Trp His Ala Gly Thr Tyr Ser Cys Val Ala Glu Asn 
385                 390                 395                 400 


Ile Leu Gly Thr Gly Gln Arg Gly Pro Gly Ala Glu Leu Asp Val Gln 
                405                 410                 415     


Tyr Pro Pro Lys Lys Val Thr Thr Val Ile Gln Asn Pro Met Pro Ile 
            420                 425                 430         


Arg Glu Gly Asp Thr Val Thr Leu Ser Cys Asn Tyr Asn Ser Ser Asn 
        435                 440                 445             


Pro Ser Val Thr Arg Tyr Glu Trp Lys Pro His Gly Ala Trp Glu Glu 
    450                 455                 460                 


Pro Ser Leu Gly Val Leu Lys Ile Gln Asn Val Gly Trp Asp Asn Thr 
465                 470                 475                 480 


Thr Ile Ala Cys Ala Ala Cys Asn Ser Trp Cys Ser Trp Ala Ser Pro 
                485                 490                 495     


Val Ala Leu Asn Val Gln Tyr Ala Pro Arg Asp Val Arg Val Arg Lys 
            500                 505                 510         


Ile Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser Val Ser Leu Gln 
        515                 520                 525             


Cys Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln Phe Phe Trp Glu 
    530                 535                 540                 


Lys Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu Asn Phe Asp Ser 
545                 550                 555                 560 


Ile Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val Asn Asn Ser 
                565                 570                 575     


Ile Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu Val Leu Tyr Ala 
            580                 585                 590         


Pro Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp Gln Val Met Glu 
        595                 600                 605             


Gly Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala Asn Pro Pro Val 
    610                 615                 620                 


Ser His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser Leu Pro Tyr His 
625                 630                 635                 640 


Ser Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln His Ser Gly Ala 
                645                 650                 655     


Tyr Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly Arg Ser Pro Leu 
            660                 665                 670         


Ser Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Ile Gly Arg Arg Val 
        675                 680                 685             


Ala Val Gly Leu Gly Ser Cys Leu Ala Ile Leu Ile Leu Ala Ile Cys 
    690                 695                 700                 


Gly Leu Lys Leu Gln Arg Arg Trp Lys Arg Thr Gln Ser Gln Gln Gly 
705                 710                 715                 720 


Leu Gln Glu Asn Ser Ser Gly Gln Ser Phe Phe Val Arg Asn Lys Lys 
                725                 730                 735     


Arg Cys Arg Val Leu Arg Asp Ala Glu Thr Ser Pro Gly Leu Arg 
            740                 745                 750     


<210>  2272
<211>  38
<212>  PRT
<213>  Homo Sapiens

<400>  2272

Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Asn Gly Phe Leu 
1               5                   10                  15      


Ser Thr Leu Lys Pro Ser Thr Pro Gly Arg Gly Pro Ala Ser Gly Ser 
            20                  25                  30          


Pro Ala Pro Thr Glu Pro 
        35              


<210>  2273
<211>  675
<212>  PRT
<213>  Homo Sapiens

<400>  2273

Met Ser Leu Trp Leu Leu Glu Gly Val Pro Met Arg Gln Ala Ala Val 
1               5                   10                  15      


Thr Ser Thr Ser Leu Thr Ile Lys Ser Val Phe Thr Arg Ser Glu Leu 
            20                  25                  30          


Lys Phe Ser Pro Gln Trp Ser His His Gly Lys Ile Val Thr Cys Gln 
        35                  40                  45              


Leu Gln Asp Ala Asp Gly Lys Phe Leu Ser Asn Asp Thr Val Gln Leu 
    50                  55                  60                  


Asn Val Lys His Thr Pro Lys Leu Glu Ile Lys Val Thr Pro Ser Asp 
65                  70                  75                  80  


Ala Ile Val Arg Glu Gly Asp Ser Val Thr Met Thr Cys Glu Val Ser 
                85                  90                  95      


Ser Ser Asn Pro Glu Tyr Thr Thr Val Ser Trp Leu Lys Asp Gly Thr 
            100                 105                 110         


Ser Leu Lys Lys Gln Asn Thr Phe Thr Leu Asn Leu Arg Glu Val Thr 
        115                 120                 125             


Lys Asp Gln Ser Gly Lys Tyr Cys Cys Gln Val Ser Asn Asp Val Gly 
    130                 135                 140                 


Pro Gly Arg Ser Glu Glu Val Phe Leu Gln Val Gln Tyr Ala Pro Glu 
145                 150                 155                 160 


Pro Ser Thr Val Gln Ile Leu His Ser Pro Ala Val Glu Gly Ser Gln 
                165                 170                 175     


Val Glu Phe Leu Cys Met Ser Leu Ala Asn Pro Leu Pro Thr Asn Tyr 
            180                 185                 190         


Thr Trp Tyr His Asn Gly Lys Glu Met Gln Gly Arg Thr Glu Glu Lys 
        195                 200                 205             


Val His Ile Pro Lys Ile Leu Pro Trp His Ala Gly Thr Tyr Ser Cys 
    210                 215                 220                 


Val Ala Glu Asn Ile Leu Gly Thr Gly Gln Arg Gly Pro Gly Ala Glu 
225                 230                 235                 240 


Leu Asp Val Gln Tyr Pro Pro Lys Lys Val Thr Thr Val Ile Gln Asn 
                245                 250                 255     


Pro Met Pro Ile Arg Glu Gly Asp Thr Val Thr Leu Ser Cys Asn Tyr 
            260                 265                 270         


Asn Ser Ser Asn Pro Ser Val Thr Arg Tyr Glu Trp Lys Pro His Gly 
        275                 280                 285             


Ala Trp Glu Glu Pro Ser Leu Gly Val Leu Lys Ile Gln Asn Val Gly 
    290                 295                 300                 


Trp Asp Asn Thr Thr Ile Ala Cys Ala Ala Cys Asn Ser Trp Cys Ser 
305                 310                 315                 320 


Trp Ala Ser Pro Val Ala Leu Asn Val Gln Tyr Ala Pro Arg Asp Val 
                325                 330                 335     


Arg Val Arg Lys Ile Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser 
            340                 345                 350         


Val Ser Leu Gln Cys Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln 
        355                 360                 365             


Phe Phe Trp Glu Lys Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu 
    370                 375                 380                 


Asn Phe Asp Ser Ile Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp 
385                 390                 395                 400 


Val Asn Asn Ser Ile Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu 
                405                 410                 415     


Val Leu Tyr Ala Pro Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp 
            420                 425                 430         


Gln Val Met Glu Gly Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala 
        435                 440                 445             


Asn Pro Pro Val Ser His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser 
    450                 455                 460                 


Leu Pro Tyr His Ser Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln 
465                 470                 475                 480 


His Ser Gly Ala Tyr Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly 
                485                 490                 495     


Arg Ser Pro Leu Ser Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Ile 
            500                 505                 510         


Gly Arg Arg Val Ala Val Gly Leu Gly Ser Cys Leu Ala Ile Leu Ile 
        515                 520                 525             


Leu Ala Ile Cys Gly Leu Lys Leu Gln Arg Arg Trp Lys Arg Thr Gln 
    530                 535                 540                 


Ser Gln Gln Gly Leu Gln Glu Asn Ser Ser Gly Gln Ser Phe Phe Val 
545                 550                 555                 560 


Arg Asn Lys Lys Val Arg Arg Ala Pro Leu Ser Glu Gly Pro His Ser 
                565                 570                 575     


Leu Gly Cys Tyr Asn Pro Met Met Glu Asp Gly Ile Ser Tyr Thr Thr 
            580                 585                 590         


Leu Arg Phe Pro Glu Met Asn Ile Pro Arg Thr Gly Asp Ala Glu Ser 
        595                 600                 605             


Ser Glu Met Gln Arg Pro Pro Pro Asp Cys Asp Asp Thr Val Thr Tyr 
    610                 615                 620                 


Ser Ala Leu His Lys Arg Gln Val Gly Asp Tyr Glu Asn Val Ile Pro 
625                 630                 635                 640 


Asp Phe Pro Glu Asp Glu Gly Ile His Tyr Ser Glu Leu Ile Gln Phe 
                645                 650                 655     


Gly Val Gly Glu Arg Pro Gln Ala Gln Glu Asn Val Asp Tyr Val Ile 
            660                 665                 670         


Leu Lys His 
        675 


<210>  2274
<211>  145
<212>  PRT
<213>  Homo Sapiens

<400>  2274

Asn Pro Leu Pro Thr Asn Tyr Thr Trp Tyr His Asn Gly Lys Glu Met 
1               5                   10                  15      


Gln Gly Arg Thr Glu Glu Lys Val His Ile Pro Lys Ile Leu Pro Trp 
            20                  25                  30          


His Ala Gly Thr Tyr Ser Cys Val Ala Glu Asn Ile Leu Gly Thr Gly 
        35                  40                  45              


Gln Arg Gly Pro Gly Ala Glu Leu Asp Val Gln Tyr Pro Pro Lys Lys 
    50                  55                  60                  


Val Thr Thr Val Ile Gln Asn Pro Met Pro Ile Arg Glu Gly Asp Thr 
65                  70                  75                  80  


Val Thr Leu Ser Cys Asn Tyr Asn Ser Ser Asn Pro Ser Val Thr Arg 
                85                  90                  95      


Tyr Glu Trp Lys Pro His Gly Ala Trp Glu Glu Pro Ser Leu Gly Val 
            100                 105                 110         


Leu Lys Ile Gln Asn Val Gly Trp Asp Asn Thr Thr Ile Ala Cys Ala 
        115                 120                 125             


Ala Cys Asn Ser Trp Cys Ser Trp Ala Ser Pro Val Ala Leu Asn Val 
    130                 135                 140                 


Gln 
145 


<210>  2275
<211>  148
<212>  PRT
<213>  Homo Sapiens

<400>  2275

Val Leu Glu Tyr Leu Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu 
1               5                   10                  15      


His Pro Glu Thr Leu Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro 
            20                  25                  30          


Cys Thr Tyr Arg Ala Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe 
        35                  40                  45              


His Asn Pro Glu Tyr Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg 
    50                  55                  60                  


Leu Tyr Glu Ser Thr Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg 
65                  70                  75                  80  


Val Gln Phe Leu Gly Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His 
                85                  90                  95      


Pro Val His Leu Asn Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser 
            100                 105                 110         


Lys Thr Glu Lys Trp Met Glu Arg Ile His Leu Asn Val Ser Val Glu 
        115                 120                 125             


Ser Pro Trp Glu Asp Cys Asp Leu Pro Ala Ser Gly Cys Arg Trp Glu 
    130                 135                 140                 


Val Pro Leu Gln 
145             


<210>  2276
<211>  37
<212>  PRT
<213>  Homo Sapiens

<400>  2276

Ile Val Ile Pro Asp Val Thr Val Ser Asp Ser Gly Leu Tyr Arg Cys 
1               5                   10                  15      


Tyr Leu Gln Ala Ser Ala Gly Glu Asn Glu Thr Phe Val Met Arg Leu 
            20                  25                  30          


Thr Val Ala Glu Gly 
        35          


<210>  2277
<211>  127
<212>  PRT
<213>  Homo Sapiens

<400>  2277

Met Asp Tyr Pro Thr Leu Leu Leu Ala Leu Leu His Val Tyr Arg Ala 
1               5                   10                  15      


Leu Cys Glu Glu Val Leu Trp His Thr Ser Val Pro Phe Ala Glu Asn 
            20                  25                  30          


Met Ser Leu Glu Cys Val Tyr Pro Ser Met Gly Ile Leu Thr Gln Val 
        35                  40                  45              


Glu Trp Phe Lys Ile Gly Thr Gln Gln Asp Ser Ile Ala Ile Phe Ser 
    50                  55                  60                  


Pro Thr His Gly Met Val Ile Arg Lys Pro Tyr Ala Glu Arg Val Tyr 
65                  70                  75                  80  


Phe Leu Asn Ser Thr Met Ala Ser Asn Asn Met Thr Leu Phe Phe Arg 
                85                  90                  95      


Asn Ala Ser Glu Asp Asp Val Gly Tyr Tyr Ser Cys Ser Leu Tyr Thr 
            100                 105                 110         


Tyr Pro Gln Gly Thr Trp Gln Lys Val Ile Gln Val Val Gln Ser 
        115                 120                 125         


<210>  2278
<211>  132
<212>  PRT
<213>  Homo Sapiens

<400>  2278

Met Asp Tyr Pro Thr Leu Leu Leu Ala Leu Leu His Val Tyr Arg Ala 
1               5                   10                  15      


Leu Cys Glu Glu Val Leu Trp His Thr Ser Val Pro Phe Ala Glu Asn 
            20                  25                  30          


Met Ser Leu Glu Cys Val Tyr Pro Ser Met Gly Ile Leu Thr Gln Val 
        35                  40                  45              


Glu Trp Phe Lys Ile Gly Thr Gln Gln Asp Ser Ile Ala Ile Phe Ser 
    50                  55                  60                  


Pro Thr His Gly Met Val Ile Arg Lys Pro Tyr Ala Glu Arg Val Tyr 
65                  70                  75                  80  


Phe Leu Asn Ser Thr Met Ala Ser Asn Asn Met Thr Leu Phe Phe Arg 
                85                  90                  95      


Asn Ala Ser Glu Asp Asp Val Gly Tyr Tyr Ser Cys Ser Leu Tyr Thr 
            100                 105                 110         


Tyr Pro Gln Gly Thr Trp Gln Lys Val Ile Gln Val Val Gln Ser Asp 
        115                 120                 125             


Ser Phe Glu Ala 
    130         


<210>  2279
<211>  336
<212>  PRT
<213>  Homo Sapiens

<400>  2279

Met Asp Tyr Pro Thr Leu Leu Leu Ala Leu Leu His Val Tyr Arg Ala 
1               5                   10                  15      


Leu Cys Glu Glu Val Leu Trp His Thr Ser Val Pro Phe Ala Glu Asn 
            20                  25                  30          


Met Ser Leu Glu Cys Val Tyr Pro Ser Met Gly Ile Leu Thr Gln Val 
        35                  40                  45              


Glu Trp Phe Lys Ile Gly Thr Gln Gln Asp Ser Ile Ala Ile Phe Ser 
    50                  55                  60                  


Pro Thr His Gly Met Val Ile Arg Lys Pro Tyr Ala Glu Arg Val Tyr 
65                  70                  75                  80  


Phe Leu Asn Ser Thr Met Ala Ser Asn Asn Met Thr Leu Phe Phe Arg 
                85                  90                  95      


Asn Ala Ser Glu Asp Asp Val Gly Tyr Tyr Ser Cys Ser Leu Tyr Thr 
            100                 105                 110         


Tyr Pro Gln Gly Thr Trp Gln Lys Val Ile Gln Val Val Gln Ser Asp 
        115                 120                 125             


Ser Phe Glu Ala Ala Val Pro Ser Asn Ser His Ile Val Ser Glu Pro 
    130                 135                 140                 


Gly Lys Asn Val Thr Leu Thr Cys Gln Pro Gln Met Thr Trp Pro Val 
145                 150                 155                 160 


Gln Ala Val Arg Trp Glu Lys Ile Gln Pro Arg Gln Ile Asp Leu Leu 
                165                 170                 175     


Thr Tyr Cys Asn Leu Val His Gly Arg Asn Phe Thr Ser Lys Phe Pro 
            180                 185                 190         


Arg Gln Ile Val Ser Asn Cys Ser His Gly Arg Trp Ser Val Ile Val 
        195                 200                 205             


Ile Pro Asp Val Thr Val Ser Asp Ser Gly Leu Tyr Arg Cys Tyr Leu 
    210                 215                 220                 


Gln Ala Ser Ala Gly Glu Asn Glu Thr Phe Val Met Arg Leu Thr Val 
225                 230                 235                 240 


Ala Glu Gly Lys Thr Asp Asn Gln Tyr Thr Leu Phe Val Ala Gly Gly 
                245                 250                 255     


Thr Val Leu Leu Leu Leu Phe Val Ile Ser Ile Thr Thr Ile Ile Val 
            260                 265                 270         


Ile Phe Leu Asn Arg Arg Arg Arg Arg Glu Arg Arg Asp Leu Phe Thr 
        275                 280                 285             


Glu Ser Trp Asp Thr Gln Lys Ala Pro Asn Asn Tyr Arg Ser Pro Ile 
    290                 295                 300                 


Ser Thr Ser Gln Pro Thr Asn Gln Ser Met Asp Asp Thr Arg Glu Asp 
305                 310                 315                 320 


Ile Tyr Val Asn Tyr Pro Thr Phe Ser Arg Arg Pro Lys Thr Arg Val 
                325                 330                 335     


<210>  2280
<211>  276
<212>  PRT
<213>  Homo Sapiens

<400>  2280

Met Asp Tyr Pro Thr Leu Leu Leu Ala Leu Leu His Val Tyr Arg Ala 
1               5                   10                  15      


Leu Cys Glu Glu Val Leu Trp His Thr Ser Val Pro Phe Ala Glu Asn 
            20                  25                  30          


Met Ser Leu Glu Cys Val Tyr Pro Ser Met Gly Ile Leu Thr Gln Val 
        35                  40                  45              


Glu Trp Phe Lys Ile Gly Thr Gln Gln Asp Ser Ile Ala Ile Phe Ser 
    50                  55                  60                  


Pro Thr His Gly Met Val Ile Arg Lys Pro Tyr Ala Glu Arg Val Tyr 
65                  70                  75                  80  


Phe Leu Asn Ser Thr Met Ala Ser Asn Asn Met Thr Leu Phe Phe Arg 
                85                  90                  95      


Asn Ala Ser Glu Asp Asp Val Gly Tyr Tyr Ser Cys Ser Leu Tyr Thr 
            100                 105                 110         


Tyr Pro Gln Gly Thr Trp Gln Lys Val Ile Gln Val Val Gln Ser Asp 
        115                 120                 125             


Ser Phe Glu Ala Ala Val Pro Ser Asn Ser His Ile Val Ser Glu Pro 
    130                 135                 140                 


Gly Lys Asn Val Thr Leu Thr Cys Gln Pro Gln Met Thr Trp Pro Val 
145                 150                 155                 160 


Gln Ala Val Arg Trp Glu Lys Ile Gln Pro Arg Gln Ile Asp Leu Leu 
                165                 170                 175     


Thr Tyr Cys Asn Leu Val His Gly Arg Asn Phe Thr Ser Lys Phe Pro 
            180                 185                 190         


Arg Gln Ile Val Ser Asn Cys Ser His Gly Arg Trp Ser Val Ile Val 
        195                 200                 205             


Ile Pro Asp Val Thr Val Ser Asp Ser Gly Leu Tyr Arg Cys Tyr Leu 
    210                 215                 220                 


Gln Ala Ser Ala Gly Glu Asn Glu Thr Phe Val Met Arg Leu Thr Val 
225                 230                 235                 240 


Ala Glu Gly Lys Thr Asp Asn Gln Tyr Thr Leu Phe Val Ala Gly Gly 
                245                 250                 255     


Thr Val Leu Leu Leu Leu Phe Val Ile Ser Ile Thr Thr Ile Ile Val 
            260                 265                 270         


Ile Phe Leu Asn 
        275     


<210>  2281
<211>  336
<212>  PRT
<213>  Homo Sapiens

<400>  2281

Met Asp Tyr Pro Thr Leu Leu Leu Ala Leu Leu His Val Tyr Arg Ala 
1               5                   10                  15      


Leu Cys Glu Glu Val Leu Trp His Thr Ser Val Pro Phe Ala Glu Asn 
            20                  25                  30          


Met Ser Leu Glu Cys Val Tyr Pro Ser Met Gly Ile Leu Thr Gln Val 
        35                  40                  45              


Glu Trp Phe Lys Ile Gly Thr Gln Gln Asp Ser Ile Ala Ile Phe Ser 
    50                  55                  60                  


Pro Thr His Gly Met Val Ile Arg Lys Pro Tyr Ala Glu Arg Val Tyr 
65                  70                  75                  80  


Phe Leu Asn Ser Thr Met Ala Ser Asn Asn Met Thr Leu Phe Phe Arg 
                85                  90                  95      


Asn Ala Ser Glu Asp Asp Val Gly Tyr Tyr Ser Cys Ser Leu Tyr Thr 
            100                 105                 110         


Tyr Pro Gln Gly Thr Trp Gln Lys Val Ile Gln Val Val Gln Ser Asp 
        115                 120                 125             


Ser Phe Glu Ala Ala Val Pro Ser Asn Ser His Ile Val Ser Glu Pro 
    130                 135                 140                 


Gly Lys Asn Val Thr Leu Thr Cys Gln Pro Gln Met Thr Trp Pro Val 
145                 150                 155                 160 


Gln Ala Val Arg Trp Glu Lys Ile Gln Pro Arg Gln Ile Asp Leu Leu 
                165                 170                 175     


Thr Tyr Cys Asn Leu Val His Gly Arg Asn Phe Thr Ser Lys Phe Pro 
            180                 185                 190         


Arg Gln Ile Val Ser Asn Cys Ser His Gly Arg Trp Ser Val Ile Val 
        195                 200                 205             


Ile Pro Asp Val Thr Val Ser Asp Ser Gly Leu Tyr Arg Cys Tyr Leu 
    210                 215                 220                 


Gln Ala Ser Ala Gly Glu Asn Glu Thr Phe Val Met Arg Leu Thr Val 
225                 230                 235                 240 


Ala Glu Gly Lys Thr Asp Asn Gln Tyr Thr Leu Phe Val Ala Gly Gly 
                245                 250                 255     


Thr Val Leu Leu Leu Leu Phe Val Ile Ser Ile Thr Thr Ile Ile Val 
            260                 265                 270         


Ile Phe Leu Asn Arg Arg Arg Arg Arg Glu Arg Arg Asp Leu Phe Thr 
        275                 280                 285             


Glu Ser Trp Asp Thr Gln Lys Ala Pro Asn Asn Tyr Arg Ser Pro Ile 
    290                 295                 300                 


Ser Thr Ser Gln Pro Thr Asn Gln Ser Met Asp Asp Thr Arg Glu Asp 
305                 310                 315                 320 


Ile Tyr Val Asn Tyr Pro Thr Phe Ser Arg Arg Pro Lys Thr Arg Val 
                325                 330                 335     


<210>  2282
<211>  181
<212>  PRT
<213>  Homo Sapiens

<400>  2282

Met Thr Trp Pro Val Gln Ala Val Arg Trp Glu Lys Ile Gln Pro Arg 
1               5                   10                  15      


Gln Ile Asp Leu Leu Thr Tyr Cys Asn Leu Val His Gly Arg Asn Phe 
            20                  25                  30          


Thr Ser Lys Phe Pro Arg Gln Ile Val Ser Asn Cys Ser His Gly Arg 
        35                  40                  45              


Trp Ser Val Ile Val Ile Pro Asp Val Thr Val Ser Asp Ser Gly Leu 
    50                  55                  60                  


Tyr Arg Cys Tyr Leu Gln Ala Ser Ala Gly Glu Asn Glu Thr Phe Val 
65                  70                  75                  80  


Met Arg Leu Thr Val Ala Glu Gly Lys Thr Asp Asn Gln Tyr Thr Leu 
                85                  90                  95      


Phe Val Ala Gly Gly Thr Val Leu Leu Leu Leu Phe Val Ile Ser Ile 
            100                 105                 110         


Thr Thr Ile Ile Val Ile Phe Leu Asn Arg Arg Arg Arg Arg Glu Arg 
        115                 120                 125             


Arg Asp Leu Phe Thr Glu Ser Trp Asp Thr Gln Lys Ala Pro Asn Asn 
    130                 135                 140                 


Tyr Arg Ser Pro Ile Ser Thr Ser Gln Pro Thr Asn Gln Ser Met Asp 
145                 150                 155                 160 


Asp Thr Arg Glu Asp Ile Tyr Val Asn Tyr Pro Thr Phe Ser Arg Arg 
                165                 170                 175     


Pro Lys Thr Arg Val 
            180     


<210>  2283
<211>  181
<212>  PRT
<213>  Homo Sapiens

<400>  2283

Met Thr Trp Pro Val Gln Ala Val Arg Trp Glu Lys Ile Gln Pro Arg 
1               5                   10                  15      


Gln Ile Asp Leu Leu Thr Tyr Cys Asn Leu Val His Gly Arg Asn Phe 
            20                  25                  30          


Thr Ser Lys Phe Pro Arg Gln Ile Val Ser Asn Cys Ser His Gly Arg 
        35                  40                  45              


Trp Ser Val Ile Val Ile Pro Asp Val Thr Val Ser Asp Ser Gly Leu 
    50                  55                  60                  


Tyr Arg Cys Tyr Leu Gln Ala Ser Ala Gly Glu Asn Glu Thr Phe Val 
65                  70                  75                  80  


Met Arg Leu Thr Val Ala Glu Gly Lys Thr Asp Asn Gln Tyr Thr Leu 
                85                  90                  95      


Phe Val Ala Gly Gly Thr Val Leu Leu Leu Leu Phe Val Ile Ser Ile 
            100                 105                 110         


Thr Thr Ile Ile Val Ile Phe Leu Asn Arg Arg Arg Arg Arg Glu Arg 
        115                 120                 125             


Arg Asp Leu Phe Thr Glu Ser Trp Asp Thr Gln Lys Ala Pro Asn Asn 
    130                 135                 140                 


Tyr Arg Ser Pro Ile Ser Thr Ser Gln Pro Thr Asn Gln Ser Met Asp 
145                 150                 155                 160 


Asp Thr Arg Glu Asp Ile Tyr Val Asn Tyr Pro Thr Phe Ser Arg Arg 
                165                 170                 175     


Pro Lys Thr Arg Val 
            180     


<210>  2284
<211>  80
<212>  PRT
<213>  Homo Sapiens

<400>  2284

Met Gly Arg Ala Met Val Ala Arg Leu Gly Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Ala Leu Leu Leu Pro Thr Gln Ile Tyr Ser Ser Glu Thr Thr Thr Gly 
            20                  25                  30          


Thr Ser Ser Asn Ser Ser Gln Ser Thr Ser Asn Ser Gly Leu Ala Pro 
        35                  40                  45              


Asn Pro Thr Asn Ala Thr Thr Lys Ala Ala Gly Gly Ala Leu Gln Ser 
    50                  55                  60                  


Thr Ala Ser Leu Phe Val Val Ser Leu Ser Leu Leu His Leu Tyr Ser 
65                  70                  75                  80  


<210>  2285
<211>  80
<212>  PRT
<213>  Homo Sapiens

<400>  2285

Met Gly Arg Ala Met Val Ala Arg Leu Gly Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Ala Leu Leu Leu Pro Thr Gln Ile Tyr Ser Ser Glu Thr Thr Thr Gly 
            20                  25                  30          


Thr Ser Ser Asn Ser Ser Gln Ser Thr Ser Asn Ser Gly Leu Ala Pro 
        35                  40                  45              


Asn Pro Thr Asn Ala Thr Thr Lys Ala Ala Gly Gly Ala Leu Gln Ser 
    50                  55                  60                  


Thr Ala Ser Leu Phe Val Val Ser Leu Ser Leu Leu His Leu Tyr Ser 
65                  70                  75                  80  


<210>  2286
<211>  80
<212>  PRT
<213>  Homo Sapiens

<400>  2286

Met Gly Arg Ala Met Val Ala Arg Leu Gly Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Ala Leu Leu Leu Pro Thr Gln Ile Tyr Ser Ser Glu Thr Thr Thr Gly 
            20                  25                  30          


Thr Ser Ser Asn Ser Ser Gln Ser Thr Ser Asn Ser Gly Leu Ala Pro 
        35                  40                  45              


Asn Pro Thr Asn Ala Thr Thr Lys Ala Ala Gly Gly Ala Leu Gln Ser 
    50                  55                  60                  


Thr Ala Ser Leu Phe Val Val Ser Leu Ser Leu Leu His Leu Tyr Ser 
65                  70                  75                  80  


<210>  2287
<211>  37
<212>  PRT
<213>  Homo Sapiens

<400>  2287

Met Gly Arg Ala Met Val Ala Arg Leu Gly Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Ala Leu Leu Leu Pro Thr Gln Lys Met Leu Arg Ile Pro Asn Leu Ile 
            20                  25                  30          


Asp Leu Lys Asn Met 
        35          


<210>  2288
<211>  129
<212>  PRT
<213>  Homo Sapiens

<400>  2288

Met Val Gly Arg Phe Cys Pro Glu Ser Pro Pro Gly Phe Val Arg Val 
1               5                   10                  15      


Ala Ala Thr Ser Ala Val Ser Leu Asp Pro Pro Ser Gly Glu Pro Arg 
            20                  25                  30          


Pro Gly Cys Gly Tyr Pro Gly Pro Arg Ser Ala Ala Ser Arg Val Tyr 
        35                  40                  45              


Gly Cys Thr Ala Pro Ala Arg Glu Thr Gly Gly Trp Ala Trp Glu Thr 
    50                  55                  60                  


Leu Ala Gly Ala Gly Ala Lys Lys Ile Tyr Ser Ser Glu Thr Thr Thr 
65                  70                  75                  80  


Gly Thr Ser Ser Asn Ser Ser Gln Ser Thr Ser Asn Ser Gly Leu Ala 
                85                  90                  95      


Pro Asn Pro Thr Asn Ala Thr Thr Lys Ala Ala Gly Gly Ala Leu Gln 
            100                 105                 110         


Ser Thr Ala Ser Leu Phe Val Val Ser Leu Ser Leu Leu His Leu Tyr 
        115                 120                 125             


Ser 
    


<210>  2289
<211>  88
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2289

Xaa Asp Arg Ser Gly Pro Gly His Arg Leu Arg Gly Ala Pro Thr Ser 
1               5                   10                  15      


Arg Glu Gly Phe Ala Leu Gly Gly Ala Arg Val Pro Ser Ala Arg Ile 
            20                  25                  30          


Tyr Ser Ser Glu Thr Thr Thr Gly Thr Ser Ser Asn Ser Ser Gln Ser 
        35                  40                  45              


Thr Ser Asn Ser Gly Leu Ala Pro Asn Pro Thr Asn Ala Thr Thr Lys 
    50                  55                  60                  


Ala Ala Gly Gly Ala Leu Gln Ser Thr Ala Ser Leu Phe Val Val Ser 
65                  70                  75                  80  


Leu Ser Leu Leu His Leu Tyr Ser 
                85              


<210>  2290
<211>  122
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2290

Xaa Leu Ser Ser Ala Ala Gly Arg Glu Ile Thr Leu Pro Glu Gly Ser 
1               5                   10                  15      


Arg Arg Pro Pro Pro Thr Arg Ser His Trp Asn Ser Gln Pro Leu Ser 
            20                  25                  30          


Gly Pro Arg Gly Ala Phe Cys Ser Leu Ser Gly Asn Ala Leu Ala Pro 
        35                  40                  45              


Gly Gln Ala Ala Thr Pro Pro Gln Arg Arg Arg Gly Leu Phe Phe Trp 
    50                  55                  60                  


Gly Ile Tyr Ser Ser Glu Thr Thr Thr Gly Thr Ser Ser Asn Ser Ser 
65                  70                  75                  80  


Gln Ser Thr Ser Asn Ser Gly Leu Ala Pro Asn Pro Thr Asn Ala Thr 
                85                  90                  95      


Thr Lys Ala Ala Gly Gly Ala Leu Gln Ser Thr Ala Ser Leu Phe Val 
            100                 105                 110         


Val Ser Leu Ser Leu Leu His Leu Tyr Ser 
        115                 120         


<210>  2291
<211>  38
<212>  PRT
<213>  Homo Sapiens

<400>  2291

Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala 
1               5                   10                  15      


Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Ala Asp Arg Tyr Gln Thr 
            20                  25                  30          


Ala Gly Ala Gln Leu Cys 
        35              


<210>  2292
<211>  38
<212>  PRT
<213>  Homo Sapiens

<400>  2292

Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala 
1               5                   10                  15      


Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Ala Asp Arg Tyr Gln Thr 
            20                  25                  30          


Ala Gly Ala Gln Leu Cys 
        35              


<210>  2293
<211>  51
<212>  PRT
<213>  Homo Sapiens

<400>  2293

Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala 
1               5                   10                  15      


Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln 
            20                  25                  30          


Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu 
        35                  40                  45              


Cys Cys Ser 
    50      


<210>  2294
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  2294

Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala 
1               5                   10                  15      


Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln 
            20                  25                  30          


Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu 
        35                  40                  45              


Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn 
    50                  55                  60                  


Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala 
65                  70                  75                  80  


Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe 
                85                  90                  95      


Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val 
            100                 105                 110         


Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp 
        115                 120                 125             


Phe Gly Ser Ala Ala 
    130             


<210>  2295
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  2295

Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala 
1               5                   10                  15      


Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln 
            20                  25                  30          


Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu 
        35                  40                  45              


Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn 
    50                  55                  60                  


Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala 
65                  70                  75                  80  


Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe 
                85                  90                  95      


Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val 
            100                 105                 110         


Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp 
        115                 120                 125             


Phe Gly Ser Ala Ala 
    130             


<210>  2296
<211>  136
<212>  PRT
<213>  Homo Sapiens

<400>  2296

Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala 
1               5                   10                  15      


Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln 
            20                  25                  30          


Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu 
        35                  40                  45              


Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn 
    50                  55                  60                  


Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala 
65                  70                  75                  80  


Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe 
                85                  90                  95      


Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val 
            100                 105                 110         


Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp 
        115                 120                 125             


Phe Gly Ser Ala Ala Val Ser Leu 
    130                 135     


<210>  2297
<211>  156
<212>  PRT
<213>  Homo Sapiens

<400>  2297

Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala 
1               5                   10                  15      


Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln 
            20                  25                  30          


Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu 
        35                  40                  45              


Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn 
    50                  55                  60                  


Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala 
65                  70                  75                  80  


Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe 
                85                  90                  95      


Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val 
            100                 105                 110         


Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp 
        115                 120                 125             


Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys 
    130                 135                 140                 


Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg 
145                 150                 155     


<210>  2298
<211>  165
<212>  PRT
<213>  Homo Sapiens

<400>  2298

Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala 
1               5                   10                  15      


Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln 
            20                  25                  30          


Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu 
        35                  40                  45              


Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn 
    50                  55                  60                  


Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala 
65                  70                  75                  80  


Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe 
                85                  90                  95      


Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val 
            100                 105                 110         


Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp 
        115                 120                 125             


Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys 
    130                 135                 140                 


Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr 
145                 150                 155                 160 


Val Thr Ile Thr Cys 
                165 


<210>  2299
<211>  534
<212>  PRT
<213>  Homo Sapiens

<400>  2299

Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala 
1               5                   10                  15      


Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln 
            20                  25                  30          


Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu 
        35                  40                  45              


Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn 
    50                  55                  60                  


Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala 
65                  70                  75                  80  


Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe 
                85                  90                  95      


Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val 
            100                 105                 110         


Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp 
        115                 120                 125             


Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys 
    130                 135                 140                 


Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr 
145                 150                 155                 160 


Val Thr Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro Glu Ala Glu Val 
                165                 170                 175     


Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr 
            180                 185                 190         


Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Ile Leu 
        195                 200                 205             


Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn 
    210                 215                 220                 


Pro Val Leu Gln Gln Asp Ala His Ser Ser Val Thr Ile Thr Pro Gln 
225                 230                 235                 240 


Arg Ser Pro Thr Gly Ala Val Glu Val Gln Val Pro Glu Asp Pro Val 
                245                 250                 255     


Val Ala Leu Val Gly Thr Asp Ala Thr Leu Arg Cys Ser Phe Ser Pro 
            260                 265                 270         


Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn Leu Ile Trp Gln Leu Thr 
        275                 280                 285             


Asp Thr Lys Gln Leu Val His Ser Phe Thr Glu Gly Arg Asp Gln Gly 
    290                 295                 300                 


Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln 
305                 310                 315                 320 


Gly Asn Ala Ser Leu Arg Leu Gln Arg Val Arg Val Ala Asp Glu Gly 
                325                 330                 335     


Ser Phe Thr Cys Phe Val Ser Ile Arg Asp Phe Gly Ser Ala Ala Val 
            340                 345                 350         


Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys Pro Ser Met Thr Leu Glu 
        355                 360                 365             


Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr Val Thr Ile Thr Cys Ser 
    370                 375                 380                 


Ser Tyr Arg Gly Tyr Pro Glu Ala Glu Val Phe Trp Gln Asp Gly Gln 
385                 390                 395                 400 


Gly Val Pro Leu Thr Gly Asn Val Thr Thr Ser Gln Met Ala Asn Glu 
                405                 410                 415     


Gln Gly Leu Phe Asp Val His Ser Val Leu Arg Val Val Leu Gly Ala 
            420                 425                 430         


Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn Pro Val Leu Gln Gln Asp 
        435                 440                 445             


Ala His Gly Ser Val Thr Ile Thr Gly Gln Pro Met Thr Phe Pro Pro 
    450                 455                 460                 


Glu Ala Leu Trp Val Thr Val Gly Leu Ser Val Cys Leu Ile Ala Leu 
465                 470                 475                 480 


Leu Val Ala Leu Ala Phe Val Cys Trp Arg Lys Ile Lys Gln Ser Cys 
                485                 490                 495     


Glu Glu Glu Asn Ala Gly Ala Glu Asp Gln Asp Gly Glu Gly Glu Gly 
            500                 505                 510         


Ser Lys Thr Ala Leu Gln Pro Leu Lys His Ser Asp Ser Lys Glu Asp 
        515                 520                 525             


Asp Gly Gln Glu Ile Ala 
    530                 


<210>  2300
<211>  533
<212>  PRT
<213>  Homo Sapiens

<400>  2300

Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala 
1               5                   10                  15      


Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln 
            20                  25                  30          


Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu 
        35                  40                  45              


Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn 
    50                  55                  60                  


Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala 
65                  70                  75                  80  


Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe 
                85                  90                  95      


Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val 
            100                 105                 110         


Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp 
        115                 120                 125             


Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys 
    130                 135                 140                 


Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr 
145                 150                 155                 160 


Val Thr Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro Glu Ala Glu Val 
                165                 170                 175     


Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr 
            180                 185                 190         


Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Ile Leu 
        195                 200                 205             


Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn 
    210                 215                 220                 


Pro Val Leu Gln Gln Asp Ala His Ser Ser Val Thr Ile Thr Pro Gln 
225                 230                 235                 240 


Arg Ser Pro Thr Gly Ala Val Glu Val Gln Val Pro Glu Asp Pro Val 
                245                 250                 255     


Val Ala Leu Val Gly Thr Asp Ala Thr Leu Arg Cys Ser Phe Ser Pro 
            260                 265                 270         


Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn Leu Ile Trp Gln Leu Thr 
        275                 280                 285             


Asp Thr Lys Gln Leu Val His Ser Phe Thr Glu Gly Arg Asp Gln Gly 
    290                 295                 300                 


Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln 
305                 310                 315                 320 


Gly Asn Ala Ser Leu Arg Leu Gln Arg Val Arg Val Ala Asp Glu Gly 
                325                 330                 335     


Ser Phe Thr Cys Phe Val Ser Ile Arg Asp Phe Gly Ser Ala Ala Val 
            340                 345                 350         


Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys Pro Ser Met Thr Leu Glu 
        355                 360                 365             


Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr Val Thr Ile Thr Cys Ser 
    370                 375                 380                 


Ser Tyr Arg Gly Tyr Pro Glu Ala Glu Val Phe Trp Gln Asp Gly Gln 
385                 390                 395                 400 


Gly Val Pro Leu Thr Gly Asn Val Thr Thr Ser Gln Met Ala Asn Glu 
                405                 410                 415     


Gln Gly Leu Phe Asp Val His Ser Val Leu Arg Val Val Leu Gly Ala 
            420                 425                 430         


Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn Pro Val Leu Gln Gln Asp 
        435                 440                 445             


Ala His Gly Ser Val Thr Ile Thr Gly Gln Pro Met Thr Phe Pro Pro 
    450                 455                 460                 


Glu Ala Leu Trp Val Thr Val Gly Leu Ser Val Cys Leu Ile Ala Leu 
465                 470                 475                 480 


Leu Val Ala Leu Ala Phe Val Cys Trp Arg Lys Ile Lys Gln Ser Cys 
                485                 490                 495     


Glu Glu Glu Asn Ala Gly Ala Glu Asp Gln Asp Gly Glu Gly Glu Gly 
            500                 505                 510         


Ser Lys Thr Ala Leu Gln Pro Leu Lys His Ser Asp Ser Lys Glu Gly 
        515                 520                 525             


Lys Asp Thr Trp Ala 
    530             


<210>  2301
<211>  316
<212>  PRT
<213>  Homo Sapiens

<400>  2301

Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala 
1               5                   10                  15      


Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln 
            20                  25                  30          


Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu 
        35                  40                  45              


Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn 
    50                  55                  60                  


Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala 
65                  70                  75                  80  


Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe 
                85                  90                  95      


Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val 
            100                 105                 110         


Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp 
        115                 120                 125             


Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys 
    130                 135                 140                 


Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr 
145                 150                 155                 160 


Val Thr Ile Thr Cys Ser Ser Tyr Arg Gly Tyr Pro Glu Ala Glu Val 
                165                 170                 175     


Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr 
            180                 185                 190         


Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Val Leu 
        195                 200                 205             


Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn 
    210                 215                 220                 


Pro Val Leu Gln Gln Asp Ala His Gly Ser Val Thr Ile Thr Gly Gln 
225                 230                 235                 240 


Pro Met Thr Phe Pro Pro Glu Ala Leu Trp Val Thr Val Gly Leu Ser 
                245                 250                 255     


Val Cys Leu Ile Ala Leu Leu Val Ala Leu Ala Phe Val Cys Trp Arg 
            260                 265                 270         


Lys Ile Lys Gln Ser Cys Glu Glu Glu Asn Ala Gly Ala Glu Asp Gln 
        275                 280                 285             


Asp Gly Glu Gly Glu Gly Ser Lys Thr Ala Leu Gln Pro Leu Lys His 
    290                 295                 300                 


Ser Asp Ser Lys Glu Asp Asp Gly Gln Glu Ile Ala 
305                 310                 315     


<210>  2302
<211>  316
<212>  PRT
<213>  Homo Sapiens

<400>  2302

Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala 
1               5                   10                  15      


Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln 
            20                  25                  30          


Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu 
        35                  40                  45              


Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn 
    50                  55                  60                  


Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala 
65                  70                  75                  80  


Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe 
                85                  90                  95      


Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val 
            100                 105                 110         


Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp 
        115                 120                 125             


Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys 
    130                 135                 140                 


Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr 
145                 150                 155                 160 


Val Thr Ile Thr Cys Ser Ser Tyr Arg Gly Tyr Pro Glu Ala Glu Val 
                165                 170                 175     


Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr 
            180                 185                 190         


Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Val Leu 
        195                 200                 205             


Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn 
    210                 215                 220                 


Pro Val Leu Gln Gln Asp Ala His Gly Ser Val Thr Ile Thr Gly Gln 
225                 230                 235                 240 


Pro Met Thr Phe Pro Pro Glu Ala Leu Trp Val Thr Val Gly Leu Ser 
                245                 250                 255     


Val Cys Leu Ile Ala Leu Leu Val Ala Leu Ala Phe Val Cys Trp Arg 
            260                 265                 270         


Lys Ile Lys Gln Ser Cys Glu Glu Glu Asn Ala Gly Ala Glu Asp Gln 
        275                 280                 285             


Asp Gly Glu Gly Glu Gly Ser Lys Thr Ala Leu Gln Pro Leu Lys His 
    290                 295                 300                 


Ser Asp Ser Lys Glu Asp Asp Gly Gln Glu Ile Ala 
305                 310                 315     


<210>  2303
<211>  146
<212>  PRT
<213>  Homo Sapiens

<400>  2303

Met Ser Leu Lys Ala Pro Met Ser Ser Arg Lys Lys Lys Leu Tyr Leu 
1               5                   10                  15      


Gln Gln His Cys Glu Ala Gly Ala Ala Phe His His Gly Glu Pro Ser 
            20                  25                  30          


Cys Gln Pro Pro His Arg Lys Met Leu Arg Arg Arg Gly Ser Pro Gly 
        35                  40                  45              


Met Gly Val His Val Gly Ala Ala Leu Gly Ala Leu Trp Phe Cys Leu 
    50                  55                  60                  


Thr Gly Ala Leu Glu Val Gln Val Pro Glu Asp Pro Val Val Ala Leu 
65                  70                  75                  80  


Val Gly Thr Asp Ala Thr Leu Cys Cys Ser Phe Ser Pro Glu Pro Gly 
                85                  90                  95      


Phe Ser Leu Ala Gln Leu Asn Leu Ile Trp Gln Leu Thr Asp Thr Lys 
            100                 105                 110         


Gln Leu Val His Ser Phe Ala Glu Gly Gln Asp Gln Gly Ser Ala Tyr 
        115                 120                 125             


Ala Asn Arg Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln Gly Asn Ala 
    130                 135                 140                 


Ser Leu 
145     


<210>  2304
<211>  388
<212>  PRT
<213>  Homo Sapiens

<400>  2304

Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr Val Thr 
1               5                   10                  15      


Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro Glu Ala Glu Val Phe Trp 
            20                  25                  30          


Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr Ser Gln 
        35                  40                  45              


Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Ile Leu Arg Val 
    50                  55                  60                  


Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn Pro Val 
65                  70                  75                  80  


Leu Gln Gln Asp Ala His Ser Ser Val Thr Ile Thr Pro Gln Arg Ser 
                85                  90                  95      


Pro Thr Gly Ala Val Glu Val Gln Val Pro Glu Asp Pro Val Val Ala 
            100                 105                 110         


Leu Val Gly Thr Asp Ala Thr Leu Arg Cys Ser Phe Ser Pro Glu Pro 
        115                 120                 125             


Gly Phe Ser Leu Ala Gln Leu Asn Leu Ile Trp Gln Leu Thr Asp Thr 
    130                 135                 140                 


Lys Gln Leu Val His Ser Phe Thr Glu Gly Arg Asp Gln Gly Ser Ala 
145                 150                 155                 160 


Tyr Ala Asn Arg Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln Gly Asn 
                165                 170                 175     


Ala Ser Leu Arg Leu Gln Arg Val Arg Val Ala Asp Glu Gly Ser Phe 
            180                 185                 190         


Thr Cys Phe Val Ser Ile Arg Asp Phe Gly Ser Ala Ala Val Ser Leu 
        195                 200                 205             


Gln Val Ala Ala Pro Tyr Ser Lys Pro Ser Met Thr Leu Glu Pro Asn 
    210                 215                 220                 


Lys Asp Leu Arg Pro Gly Asp Thr Val Thr Ile Thr Cys Ser Ser Tyr 
225                 230                 235                 240 


Arg Gly Tyr Pro Glu Ala Glu Val Phe Trp Gln Asp Gly Gln Gly Val 
                245                 250                 255     


Pro Leu Thr Gly Asn Val Thr Thr Ser Gln Met Ala Asn Glu Gln Gly 
            260                 265                 270         


Leu Phe Asp Val His Ser Val Leu Arg Val Val Leu Gly Ala Asn Gly 
        275                 280                 285             


Thr Tyr Ser Cys Leu Val Arg Asn Pro Val Leu Gln Gln Asp Ala His 
    290                 295                 300                 


Gly Ser Val Thr Ile Thr Gly Gln Pro Met Thr Phe Pro Pro Glu Ala 
305                 310                 315                 320 


Leu Trp Val Thr Val Gly Leu Ser Val Cys Leu Ile Ala Leu Leu Val 
                325                 330                 335     


Ala Leu Ala Phe Val Cys Trp Arg Lys Ile Lys Gln Ser Cys Glu Glu 
            340                 345                 350         


Glu Asn Ala Gly Ala Glu Asp Gln Asp Gly Glu Gly Glu Gly Ser Lys 
        355                 360                 365             


Thr Ala Leu Gln Pro Leu Lys His Ser Asp Ser Lys Glu Asp Asp Gly 
    370                 375                 380                 


Gln Glu Ile Ala 
385             


<210>  2305
<211>  199
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2305

Xaa Arg Val Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser 
1               5                   10                  15      


Ile Arg Asp Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro 
            20                  25                  30          


Tyr Ser Lys Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro 
        35                  40                  45              


Gly Asp Thr Val Thr Ile Thr Cys Ser Ser Tyr Arg Gly Tyr Pro Glu 
    50                  55                  60                  


Ala Glu Val Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn 
65                  70                  75                  80  


Val Thr Thr Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val His 
                85                  90                  95      


Ser Val Leu Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu 
            100                 105                 110         


Val Arg Asn Pro Val Leu Gln Gln Asp Ala His Gly Ser Val Thr Ile 
        115                 120                 125             


Thr Glu Ala Leu Trp Val Thr Val Gly Leu Ser Val Cys Leu Ile Ala 
    130                 135                 140                 


Leu Leu Val Ala Leu Ala Phe Val Cys Trp Arg Lys Ile Lys Gln Ser 
145                 150                 155                 160 


Cys Glu Glu Glu Asn Ala Gly Ala Glu Asp Gln Asp Gly Glu Gly Glu 
                165                 170                 175     


Gly Ser Lys Thr Ala Leu Gln Pro Leu Lys His Ser Asp Ser Lys Glu 
            180                 185                 190         


Asp Asp Gly Gln Glu Ile Ala 
        195                 


<210>  2306
<211>  170
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2306

Xaa Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr Val Thr 
1               5                   10                  15      


Ile Thr Cys Ser Ser Tyr Arg Gly Tyr Pro Glu Ala Glu Val Phe Trp 
            20                  25                  30          


Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr Ser Gln 
        35                  40                  45              


Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Val Leu Arg Val 
    50                  55                  60                  


Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn Pro Val 
65                  70                  75                  80  


Leu Gln Gln Asp Ala His Gly Ser Val Thr Ile Thr Gly Gln Pro Met 
                85                  90                  95      


Thr Phe Pro Pro Glu Ala Leu Trp Val Thr Val Gly Leu Ser Val Cys 
            100                 105                 110         


Leu Ile Ala Leu Leu Val Ala Leu Ala Phe Val Cys Trp Arg Lys Ile 
        115                 120                 125             


Lys Gln Ser Cys Glu Glu Glu Asn Ala Gly Ala Glu Asp Gln Asp Gly 
    130                 135                 140                 


Glu Gly Glu Gly Ser Lys Thr Ala Leu Gln Pro Leu Lys His Ser Asp 
145                 150                 155                 160 


Ser Lys Glu Asp Asp Gly Gln Glu Ile Ala 
                165                 170 


<210>  2307
<211>  169
<212>  PRT
<213>  Homo Sapiens

<400>  2307

Met Thr Pro Ala Ser Ile Thr Ala Ala Lys Thr Ser Thr Ile Thr Thr 
1               5                   10                  15      


Ala Phe Pro Pro Val Ser Ser Thr Thr Leu Phe Ala Val Gly Ala Thr 
            20                  25                  30          


His Ser Ala Ser Ile Gln Glu Glu Thr Glu Glu Val Val Asn Ser Gln 
        35                  40                  45              


Leu Pro Leu Leu Leu Ser Leu Leu Ala Leu Leu Leu Leu Leu Leu Val 
    50                  55                  60                  


Gly Ala Ser Leu Leu Ala Trp Arg Met Phe Gln Lys Trp Ile Lys Ala 
65                  70                  75                  80  


Gly Asp His Ser Glu Leu Ser Gln Asn Pro Lys Gln Ala Ala Thr Gln 
                85                  90                  95      


Ser Glu Leu His Tyr Ala Asn Leu Glu Leu Leu Met Trp Pro Leu Gln 
            100                 105                 110         


Glu Lys Pro Ala Pro Pro Arg Glu Val Glu Val Glu Tyr Ser Thr Val 
        115                 120                 125             


Ala Ser Pro Arg Glu Glu Leu His Tyr Ala Ser Val Val Phe Asp Ser 
    130                 135                 140                 


Asn Thr Asn Arg Ile Ala Ala Gln Arg Pro Arg Glu Glu Glu Pro Asp 
145                 150                 155                 160 


Ser Asp Tyr Ser Val Ile Arg Lys Thr 
                165                 


<210>  2308
<211>  103
<212>  PRT
<213>  Homo Sapiens

<400>  2308

Met Trp Leu Pro Trp Ala Leu Leu Leu Leu Trp Val Pro Ala Gly Asp 
1               5                   10                  15      


His Ser Glu Leu Ser Gln Asn Pro Lys Gln Ala Ala Thr Gln Ser Glu 
            20                  25                  30          


Leu His Tyr Ala Asn Leu Glu Leu Leu Met Trp Pro Leu Gln Glu Lys 
        35                  40                  45              


Pro Ala Pro Pro Arg Glu Val Glu Val Glu Tyr Ser Thr Val Ala Ser 
    50                  55                  60                  


Pro Arg Glu Glu Leu His Tyr Ala Ser Val Val Phe Asp Ser Asn Thr 
65                  70                  75                  80  


Asn Arg Ile Ala Ala Gln Arg Pro Arg Glu Glu Glu Pro Asp Ser Asp 
                85                  90                  95      


Tyr Ser Val Ile Arg Lys Thr 
            100             


<210>  2309
<211>  186
<212>  PRT
<213>  Homo Sapiens

<400>  2309

Met Trp Leu Pro Trp Ala Leu Leu Leu Leu Trp Val Pro Ala Ser Thr 
1               5                   10                  15      


Ser Met Thr Pro Ala Ser Ile Thr Ala Ala Lys Thr Ser Thr Ile Thr 
            20                  25                  30          


Thr Ala Phe Pro Pro Val Ser Ser Thr Thr Leu Phe Ala Val Gly Ala 
        35                  40                  45              


Thr His Ser Ala Ser Ile Gln Glu Glu Thr Glu Glu Val Val Asn Ser 
    50                  55                  60                  


Gln Leu Pro Leu Leu Leu Ser Leu Leu Ala Leu Leu Leu Leu Leu Leu 
65                  70                  75                  80  


Val Gly Ala Ser Leu Leu Ala Trp Arg Met Phe Gln Lys Trp Ile Lys 
                85                  90                  95      


Ala Gly Asp His Ser Glu Leu Ser Gln Asn Pro Lys Gln Ala Ala Thr 
            100                 105                 110         


Gln Ser Glu Leu His Tyr Ala Asn Leu Glu Leu Leu Met Trp Pro Leu 
        115                 120                 125             


Gln Glu Lys Pro Ala Pro Pro Arg Glu Val Glu Val Glu Tyr Ser Thr 
    130                 135                 140                 


Val Ala Ser Pro Arg Glu Glu Leu His Tyr Ala Ser Val Val Phe Asp 
145                 150                 155                 160 


Ser Asn Thr Asn Arg Ile Ala Ala Gln Arg Pro Arg Glu Glu Glu Pro 
                165                 170                 175     


Asp Ser Asp Tyr Ser Val Ile Arg Lys Thr 
            180                 185     


<210>  2310
<211>  150
<212>  PRT
<213>  Homo Sapiens

<400>  2310

Met Trp Leu Pro Trp Ala Leu Leu Leu Leu Trp Val Pro Ala Ser Thr 
1               5                   10                  15      


Ser Met Thr Pro Ala Ser Ile Thr Ala Ala Lys Thr Ser Thr Ile Thr 
            20                  25                  30          


Thr Ala Phe Pro Pro Val Ser Ser Thr Thr Leu Phe Ala Val Gly Ala 
        35                  40                  45              


Thr His Ser Ala Ser Ile Gln Glu Glu Thr Glu Glu Val Val Asn Ser 
    50                  55                  60                  


Gln Leu Pro Leu Leu Leu Ser Leu Leu Ala Leu Leu Leu Leu Leu Leu 
65                  70                  75                  80  


Val Gly Ala Ser Leu Leu Ala Trp Arg Met Phe Gln Lys Trp Ile Lys 
                85                  90                  95      


Ala Gly Asp His Ser Glu Leu Ser Gln Asn Pro Lys Gln Ala Ser Pro 
            100                 105                 110         


Arg Glu Glu Leu His Tyr Ala Ser Val Val Phe Asp Ser Asn Thr Asn 
        115                 120                 125             


Arg Ile Ala Ala Gln Arg Pro Arg Glu Glu Glu Pro Asp Ser Asp Tyr 
    130                 135                 140                 


Ser Val Ile Arg Lys Thr 
145                 150 


<210>  2311
<211>  299
<212>  PRT
<213>  Homo Sapiens

<400>  2311

Met Trp Leu Pro Trp Ala Leu Leu Leu Leu Trp Val Pro Gly Cys Phe 
1               5                   10                  15      


Ala Leu Ser Lys Cys Arg Thr Val Ala Gly Pro Val Gly Gly Ser Leu 
            20                  25                  30          


Ser Val Gln Cys Pro Tyr Glu Lys Glu His Arg Thr Leu Asn Lys Tyr 
        35                  40                  45              


Trp Cys Arg Pro Pro Gln Ile Phe Leu Cys Asp Lys Ile Val Glu Thr 
    50                  55                  60                  


Lys Gly Ser Ala Gly Lys Arg Asn Gly Arg Val Ser Ile Arg Asp Ser 
65                  70                  75                  80  


Pro Ala Asn Leu Ser Phe Thr Val Thr Leu Glu Asn Leu Thr Glu Glu 
                85                  90                  95      


Asp Ala Gly Thr Tyr Trp Cys Gly Val Asp Thr Pro Trp Leu Arg Asp 
            100                 105                 110         


Phe His Asp Pro Val Val Glu Val Glu Val Ser Val Phe Pro Ala Ser 
        115                 120                 125             


Thr Ser Met Thr Pro Ala Ser Ile Thr Ala Ala Lys Thr Ser Thr Ile 
    130                 135                 140                 


Thr Thr Ala Phe Pro Pro Val Ser Ser Thr Thr Leu Phe Ala Val Gly 
145                 150                 155                 160 


Ala Thr His Ser Ala Ser Ile Gln Glu Glu Thr Glu Glu Val Val Asn 
                165                 170                 175     


Ser Gln Leu Pro Leu Leu Leu Ser Leu Leu Ala Leu Leu Leu Leu Leu 
            180                 185                 190         


Leu Val Gly Ala Ser Leu Leu Ala Trp Arg Met Phe Gln Lys Trp Ile 
        195                 200                 205             


Lys Ala Gly Asp His Ser Glu Leu Ser Gln Asn Pro Lys Gln Ala Ala 
    210                 215                 220                 


Thr Gln Ser Glu Leu His Tyr Ala Asn Leu Glu Leu Leu Met Trp Pro 
225                 230                 235                 240 


Leu Gln Glu Lys Pro Ala Pro Pro Arg Glu Val Glu Val Glu Tyr Ser 
                245                 250                 255     


Thr Val Ala Ser Pro Arg Glu Glu Leu His Tyr Ala Ser Val Val Phe 
            260                 265                 270         


Asp Ser Asn Thr Asn Arg Ile Ala Ala Gln Arg Pro Arg Glu Glu Glu 
        275                 280                 285             


Pro Asp Ser Asp Tyr Ser Val Ile Arg Lys Thr 
    290                 295                 


<210>  2312
<211>  148
<212>  PRT
<213>  Homo Sapiens

<400>  2312

Met Trp Leu Pro Pro Ala Leu Leu Leu Leu Ser Leu Ser Gly Cys Phe 
1               5                   10                  15      


Ser Ile Gln Gly Pro Glu Ser Val Arg Ala Pro Glu Gln Gly Ser Leu 
            20                  25                  30          


Thr Val Gln Cys His Tyr Lys Gln Gly Trp Glu Thr Tyr Ile Lys Trp 
        35                  40                  45              


Trp Cys Arg Gly Val Arg Trp Asp Thr Cys Lys Ile Leu Ile Glu Thr 
    50                  55                  60                  


Arg Gly Ser Glu Gln Gly Glu Lys Ser Asp Arg Val Ser Ile Lys Asp 
65                  70                  75                  80  


Asn Gln Lys Asp Arg Thr Phe Thr Val Thr Met Glu Gly Leu Arg Arg 
                85                  90                  95      


Asp Asp Ala Asp Val Tyr Trp Cys Gly Ile Glu Arg Arg Gly Pro Asp 
            100                 105                 110         


Leu Gly Thr Gln Val Lys Val Ile Val Asp Pro Glu Gly Ala Ala Ser 
        115                 120                 125             


Thr Thr Ala Ser Ser Pro Thr Asn Ser Asn Met Ala Val Phe Ile Gly 
    130                 135                 140                 


Ser His Lys Arg 
145             


<210>  2313
<211>  201
<212>  PRT
<213>  Homo Sapiens

<400>  2313

Met Trp Leu Pro Pro Ala Leu Leu Leu Leu Ser Leu Ser Gly Cys Phe 
1               5                   10                  15      


Ser Ile Gln Gly Pro Glu Ser Val Arg Ala Pro Glu Gln Gly Ser Leu 
            20                  25                  30          


Thr Val Gln Cys His Tyr Lys Gln Gly Trp Glu Thr Tyr Ile Lys Trp 
        35                  40                  45              


Trp Cys Arg Gly Val Arg Trp Asp Thr Cys Lys Ile Leu Ile Glu Thr 
    50                  55                  60                  


Arg Gly Ser Glu Gln Gly Glu Lys Ser Asp Arg Val Ser Ile Lys Asp 
65                  70                  75                  80  


Asn Gln Lys Asp Arg Thr Phe Thr Val Thr Met Glu Gly Leu Arg Arg 
                85                  90                  95      


Asp Asp Ala Asp Val Tyr Trp Cys Gly Ile Glu Arg Arg Gly Pro Asp 
            100                 105                 110         


Leu Gly Thr Gln Val Lys Val Ile Val Asp Pro Glu Gly Ala Ala Ser 
        115                 120                 125             


Thr Thr Ala Ser Ser Pro Thr Asn Ser Asn Met Ala Val Phe Ile Gly 
    130                 135                 140                 


Ser His Lys Arg Asn His Tyr Met Leu Leu Val Phe Val Lys Val Pro 
145                 150                 155                 160 


Ile Leu Leu Ile Leu Val Thr Ala Ile Leu Trp Leu Lys Gly Ser Gln 
                165                 170                 175     


Arg Val Pro Glu Glu Pro Gly Glu Gln Pro Ile Tyr Met Asn Phe Ser 
            180                 185                 190         


Glu Pro Leu Thr Lys Asp Met Ala Thr 
        195                 200     


<210>  2314
<211>  290
<212>  PRT
<213>  Homo Sapiens

<400>  2314

Met Pro Leu Leu Thr Leu Tyr Leu Leu Leu Phe Trp Leu Ser Gly Tyr 
1               5                   10                  15      


Ser Ile Val Thr Gln Ile Thr Gly Pro Thr Thr Val Asn Gly Leu Glu 
            20                  25                  30          


Arg Gly Ser Leu Thr Val Gln Cys Val Tyr Arg Ser Gly Trp Glu Thr 
        35                  40                  45              


Tyr Leu Lys Trp Trp Cys Arg Gly Ala Ile Trp Arg Asp Cys Lys Ile 
    50                  55                  60                  


Leu Val Lys Thr Ser Gly Ser Glu Gln Glu Val Lys Arg Asp Arg Val 
65                  70                  75                  80  


Ser Ile Lys Asp Asn Gln Lys Asn Arg Thr Phe Thr Val Thr Met Glu 
                85                  90                  95      


Asp Leu Met Lys Thr Asp Ala Asp Thr Tyr Trp Cys Gly Ile Glu Lys 
            100                 105                 110         


Thr Gly Asn Asp Leu Gly Val Thr Val Gln Val Thr Ile Asp Pro Ala 
        115                 120                 125             


Pro Val Thr Gln Glu Glu Thr Ser Ser Ser Pro Thr Leu Thr Gly His 
    130                 135                 140                 


His Leu Asp Asn Arg His Lys Leu Leu Lys Leu Ser Val Leu Leu Pro 
145                 150                 155                 160 


Leu Ile Phe Thr Ile Leu Leu Leu Leu Leu Val Ala Ala Ser Leu Leu 
                165                 170                 175     


Ala Trp Arg Met Met Lys Tyr Gln Gln Lys Ala Ala Gly Met Ser Pro 
            180                 185                 190         


Glu Gln Val Leu Gln Pro Leu Glu Gly Asp Leu Cys Tyr Ala Asp Leu 
        195                 200                 205             


Thr Leu Gln Leu Ala Gly Thr Ser Pro Gln Lys Ala Thr Thr Lys Leu 
    210                 215                 220                 


Ser Ser Ala Gln Val Asp Gln Val Glu Val Glu Tyr Val Thr Met Ala 
225                 230                 235                 240 


Ser Leu Pro Lys Glu Asp Ile Ser Tyr Ala Ser Leu Thr Leu Gly Ala 
                245                 250                 255     


Glu Asp Gln Glu Pro Thr Tyr Cys Asn Met Gly His Leu Ser Ser His 
            260                 265                 270         


Leu Pro Gly Arg Gly Pro Glu Glu Pro Thr Glu Tyr Ser Thr Ile Ser 
        275                 280                 285             


Arg Pro 
    290 


<210>  2315
<211>  244
<212>  PRT
<213>  Homo Sapiens

<400>  2315

Met Pro Leu Leu Thr Leu Tyr Leu Leu Leu Phe Trp Leu Ser Gly Tyr 
1               5                   10                  15      


Ser Ile Val Thr Gln Ile Thr Gly Pro Thr Thr Val Asn Gly Leu Glu 
            20                  25                  30          


Arg Gly Ser Leu Thr Val Gln Cys Val Tyr Arg Ser Gly Trp Glu Thr 
        35                  40                  45              


Tyr Leu Lys Trp Trp Cys Arg Gly Ala Ile Trp Arg Asp Cys Lys Ile 
    50                  55                  60                  


Leu Val Lys Thr Ser Gly Ser Glu Gln Glu Val Lys Arg Asp Arg Val 
65                  70                  75                  80  


Ser Ile Lys Asp Asn Gln Lys Asn Arg Thr Phe Thr Val Thr Met Glu 
                85                  90                  95      


Asp Leu Met Lys Thr Asp Ala Asp Thr Tyr Trp Cys Gly Ile Glu Lys 
            100                 105                 110         


Thr Gly Asn Asp Leu Gly Val Thr Val Gln Val Thr Ile Asp Pro Ala 
        115                 120                 125             


Pro Val Thr Gln Glu Glu Thr Ser Ser Ser Pro Thr Leu Thr Gly His 
    130                 135                 140                 


His Leu Asp Asn Arg Ser Glu Gly Ser Gln Ala Ala Asn Tyr Arg Pro 
145                 150                 155                 160 


Ala Ala His Gln Ala Gln Ala Pro Glu Ala Gln Cys Pro Pro Ala Pro 
                165                 170                 175     


His Leu His His Ile Ala Ala Ala Phe Gly Gly Arg Leu Thr Leu Gly 
            180                 185                 190         


Leu Glu Asp Asp Glu Val Pro Ala Glu Ser Ser Arg Asp Val Pro Arg 
        195                 200                 205             


Ala Gly Thr Ala Ala Pro Gly Gly Arg Pro Leu Leu Cys Arg Pro Asp 
    210                 215                 220                 


Pro Ala Ala Gly Arg Asn Leu Pro Ala Lys Gly Tyr His Glu Ala Phe 
225                 230                 235                 240 


Leu Cys Pro Gly 
                


<210>  2316
<211>  305
<212>  PRT
<213>  Homo Sapiens

<400>  2316

Met Pro Leu Leu Thr Leu Tyr Leu Leu Leu Phe Trp Leu Ser Gly Tyr 
1               5                   10                  15      


Ser Ile Val Thr Gln Ile Thr Gly Pro Thr Thr Val Asn Gly Leu Glu 
            20                  25                  30          


Arg Gly Ser Leu Thr Val Gln Cys Val Tyr Arg Ser Gly Trp Glu Thr 
        35                  40                  45              


Tyr Leu Lys Trp Trp Cys Arg Gly Ala Ile Trp Arg Asp Cys Lys Ile 
    50                  55                  60                  


Leu Val Lys Thr Ser Gly Ser Glu Gln Glu Val Lys Arg Asp Arg Val 
65                  70                  75                  80  


Ser Ile Lys Asp Asn Gln Lys Asn Arg Thr Phe Thr Val Thr Met Glu 
                85                  90                  95      


Asp Leu Met Lys Thr Asp Ala Asp Thr Tyr Trp Cys Gly Ile Glu Lys 
            100                 105                 110         


Thr Gly Asn Asp Leu Gly Val Thr Val Gln Val Thr Ile Asp Pro Ala 
        115                 120                 125             


Ser Thr Pro Ala Pro Thr Thr Pro Thr Ser Thr Thr Phe Thr Ala Pro 
    130                 135                 140                 


Val Thr Gln Glu Glu Thr Ser Ser Ser Pro Thr Leu Thr Gly His His 
145                 150                 155                 160 


Leu Asp Asn Arg His Lys Leu Leu Lys Leu Ser Val Leu Leu Pro Leu 
                165                 170                 175     


Ile Phe Thr Ile Leu Leu Leu Leu Leu Val Ala Ala Ser Leu Leu Ala 
            180                 185                 190         


Trp Arg Met Met Lys Tyr Gln Gln Lys Ala Ala Gly Met Ser Pro Glu 
        195                 200                 205             


Gln Val Leu Gln Pro Leu Glu Gly Asp Leu Cys Tyr Ala Asp Leu Thr 
    210                 215                 220                 


Leu Gln Leu Ala Gly Thr Ser Pro Gln Lys Ala Thr Thr Lys Leu Ser 
225                 230                 235                 240 


Ser Ala Gln Val Asp Gln Val Glu Val Glu Tyr Val Thr Met Ala Ser 
                245                 250                 255     


Leu Pro Lys Glu Asp Ile Ser Tyr Ala Ser Leu Thr Leu Gly Ala Glu 
            260                 265                 270         


Asp Gln Glu Pro Thr Tyr Cys Asn Met Gly His Leu Ser Ser His Leu 
        275                 280                 285             


Pro Gly Arg Gly Pro Glu Glu Pro Thr Glu Tyr Ser Thr Ile Ser Arg 
    290                 295                 300                 


Pro 
305 


<210>  2317
<211>  293
<212>  PRT
<213>  Homo Sapiens

<400>  2317

Met Trp Leu Pro Gln Leu Asp Leu Met Arg Val Ile Ser Ala Lys Ser 
1               5                   10                  15      


Gln Gly Tyr Ser Ile Val Thr Gln Ile Thr Gly Pro Thr Thr Val Asn 
            20                  25                  30          


Gly Leu Glu Arg Gly Ser Leu Thr Val Gln Cys Val Tyr Arg Ser Gly 
        35                  40                  45              


Trp Glu Thr Tyr Leu Lys Trp Trp Cys Arg Gly Ala Ile Trp Arg Asp 
    50                  55                  60                  


Cys Lys Ile Leu Val Lys Thr Ser Gly Ser Glu Gln Glu Val Lys Arg 
65                  70                  75                  80  


Asp Arg Val Ser Ile Lys Asp Asn Gln Lys Asn Arg Thr Phe Thr Val 
                85                  90                  95      


Thr Met Glu Asp Leu Met Lys Thr Asp Ala Asp Thr Tyr Trp Cys Gly 
            100                 105                 110         


Ile Glu Lys Thr Gly Asn Asp Leu Gly Val Thr Val Gln Val Thr Ile 
        115                 120                 125             


Asp Pro Ala Pro Val Thr Gln Glu Glu Thr Ser Ser Ser Pro Thr Leu 
    130                 135                 140                 


Thr Gly His His Leu Asp Asn Arg His Lys Leu Leu Lys Leu Ser Val 
145                 150                 155                 160 


Leu Leu Pro Leu Ile Phe Thr Ile Leu Leu Leu Leu Leu Val Ala Ala 
                165                 170                 175     


Ser Leu Leu Ala Trp Arg Met Met Lys Tyr Gln Gln Lys Ala Ala Gly 
            180                 185                 190         


Met Ser Pro Glu Gln Val Leu Gln Pro Leu Glu Gly Asp Leu Cys Tyr 
        195                 200                 205             


Ala Asp Leu Thr Leu Gln Leu Ala Gly Thr Ser Pro Gln Lys Ala Thr 
    210                 215                 220                 


Thr Lys Leu Ser Ser Ala Gln Val Asp Gln Val Glu Val Glu Tyr Val 
225                 230                 235                 240 


Thr Met Ala Ser Leu Pro Lys Glu Asp Ile Ser Tyr Ala Ser Leu Thr 
                245                 250                 255     


Leu Gly Ala Glu Asp Gln Glu Pro Thr Tyr Cys Asn Met Gly His Leu 
            260                 265                 270         


Ser Ser His Leu Pro Gly Arg Gly Pro Glu Glu Pro Thr Glu Tyr Ser 
        275                 280                 285             


Thr Ile Ser Arg Pro 
    290             


<210>  2318
<211>  165
<212>  PRT
<213>  Homo Sapiens

<400>  2318

Met Trp Leu Pro Gln Leu Asp Leu Met Arg Val Ile Ser Ala Lys Ser 
1               5                   10                  15      


Gln Gly Tyr Ser Ile Val Thr Gln Ile Thr Gly Pro Thr Thr Val Asn 
            20                  25                  30          


Gly Leu Glu Arg Gly Ser Leu Thr Val Gln Cys Val Tyr Arg Ser Gly 
        35                  40                  45              


Trp Glu Thr Tyr Leu Lys Trp Trp Cys Arg Gly Ala Ile Trp Arg Asp 
    50                  55                  60                  


Cys Lys Ile Leu Val Lys Thr Ser Gly Ser Glu Gln Glu Val Lys Arg 
65                  70                  75                  80  


Asp Arg Val Ser Ile Lys Asp Asn Gln Lys Asn Arg Thr Phe Thr Val 
                85                  90                  95      


Thr Met Glu Asp Leu Met Lys Thr Asp Ala Asp Thr Tyr Trp Cys Gly 
            100                 105                 110         


Ile Glu Lys Thr Gly Asn Asp Leu Gly Val Thr Val Gln Val Thr Ile 
        115                 120                 125             


Asp Pro Ala Pro Val Thr Gln Glu Glu Thr Ser Ser Ser Pro Thr Leu 
    130                 135                 140                 


Thr Gly His His Leu Asp Asn Arg Tyr Cys Ser Pro Trp Arg Ala Thr 
145                 150                 155                 160 


Ser Ala Met Gln Thr 
                165 


<210>  2319
<211>  194
<212>  PRT
<213>  Homo Sapiens

<400>  2319

Met Trp Leu Pro Gln Leu Asp Leu Met Arg Val Ile Ser Ala Lys Ser 
1               5                   10                  15      


Gln Gly Tyr Ser Ile Val Thr Gln Ile Thr Gly Pro Thr Thr Val Asn 
            20                  25                  30          


Gly Leu Glu Arg Gly Ser Leu Thr Val Gln Cys Val Tyr Arg Ser Gly 
        35                  40                  45              


Trp Glu Thr Tyr Leu Lys Trp Trp Cys Arg Gly Ala Ile Trp Arg Asp 
    50                  55                  60                  


Cys Lys Ile Leu Val Lys Thr Ser Gly Ser Glu Gln Glu Val Lys Arg 
65                  70                  75                  80  


Asp Arg Val Ser Ile Lys Asp Asn Gln Lys Asn Arg Thr Phe Thr Val 
                85                  90                  95      


Thr Met Glu Asp Leu Met Lys Thr Asp Ala Asp Thr Tyr Trp Cys Gly 
            100                 105                 110         


Ile Glu Lys Thr Gly Asn Asp Leu Gly Val Thr Val Gln Val Thr Ile 
        115                 120                 125             


Asp Pro Ala Pro Val Thr Gln Glu Glu Thr Ser Ser Ser Pro Thr Leu 
    130                 135                 140                 


Thr Gly His His Leu Asp Asn Ser Ser Arg Asp Val Pro Arg Ala Gly 
145                 150                 155                 160 


Thr Ala Ala Pro Gly Gly Arg Pro Leu Leu Cys Arg Pro Asp Pro Ala 
                165                 170                 175     


Ala Gly Arg Asn Leu Pro Ala Lys Gly Tyr His Glu Ala Phe Leu Cys 
            180                 185                 190         


Pro Gly 
        


<210>  2320
<211>  194
<212>  PRT
<213>  Homo Sapiens

<400>  2320

Met Trp Leu Pro Gln Leu Asp Leu Met Arg Val Ile Ser Ala Lys Ser 
1               5                   10                  15      


Gln Gly Tyr Ser Ile Val Thr Gln Ile Thr Gly Pro Thr Thr Val Asn 
            20                  25                  30          


Gly Leu Glu Arg Gly Ser Leu Thr Val Gln Cys Val Tyr Arg Ser Gly 
        35                  40                  45              


Trp Glu Thr Tyr Leu Lys Trp Trp Cys Arg Gly Ala Ile Trp Arg Asp 
    50                  55                  60                  


Cys Lys Ile Leu Val Lys Thr Ser Gly Ser Glu Gln Glu Val Lys Arg 
65                  70                  75                  80  


Asp Arg Val Ser Ile Lys Asp Asn Gln Lys Asn Arg Thr Phe Thr Val 
                85                  90                  95      


Thr Met Glu Asp Leu Met Lys Thr Asp Ala Asp Thr Tyr Trp Cys Gly 
            100                 105                 110         


Ile Glu Lys Thr Gly Asn Asp Leu Gly Val Thr Val Gln Val Thr Ile 
        115                 120                 125             


Asp Pro Ala Pro Val Thr Gln Glu Glu Thr Ser Ser Ser Pro Thr Leu 
    130                 135                 140                 


Thr Gly His His Leu Asp Asn Ser Ser Arg Asp Val Pro Arg Ala Gly 
145                 150                 155                 160 


Thr Ala Ala Pro Gly Gly Arg Pro Leu Leu Cys Arg Pro Asp Pro Ala 
                165                 170                 175     


Ala Gly Arg Asn Leu Pro Ala Lys Gly Tyr His Glu Ala Phe Leu Cys 
            180                 185                 190         


Pro Gly 
        


<210>  2321
<211>  239
<212>  PRT
<213>  Homo Sapiens

<400>  2321

Met Trp Leu Pro Gln Leu Asp Leu Met Arg Val Ile Ser Ala Lys Ser 
1               5                   10                  15      


Gln Gly Tyr Ser Ile Val Thr Gln Ile Thr Gly Pro Thr Thr Val Asn 
            20                  25                  30          


Gly Leu Glu Arg Gly Ser Leu Thr Val Gln Cys Val Tyr Arg Ser Gly 
        35                  40                  45              


Trp Glu Thr Tyr Leu Lys Trp Trp Cys Arg Gly Ala Ile Trp Arg Asp 
    50                  55                  60                  


Cys Lys Ile Leu Val Lys Thr Ser Gly Ser Glu Gln Glu Val Lys Arg 
65                  70                  75                  80  


Asp Arg Val Ser Ile Lys Asp Asn Gln Lys Asn Arg Thr Phe Thr Val 
                85                  90                  95      


Thr Met Glu Asp Leu Met Lys Thr Asp Ala Asp Thr Tyr Trp Cys Gly 
            100                 105                 110         


Ile Glu Lys Thr Gly Asn Asp Leu Gly Val Thr Val Gln Val Thr Ile 
        115                 120                 125             


Asp Pro Ala Ser Thr Pro Ala Pro Thr Thr Pro Thr Ser Thr Thr Phe 
    130                 135                 140                 


Thr Ala Pro Val Thr Gln Glu Glu Thr Ser Ser Ser Pro Thr Leu Thr 
145                 150                 155                 160 


Gly His His Leu Asp Asn Arg His Lys Leu Leu Lys Leu Ser Val Leu 
                165                 170                 175     


Leu Pro Leu Ile Phe Thr Ile Leu Leu Leu Leu Leu Val Ala Ala Ser 
            180                 185                 190         


Leu Leu Ala Trp Arg Met Met Lys Tyr Gln Gln Lys Gly Thr Ala Ala 
        195                 200                 205             


Pro Gly Gly Arg Pro Leu Leu Cys Arg Pro Asp Pro Ala Ala Gly Arg 
    210                 215                 220                 


Asn Leu Pro Ala Lys Gly Tyr His Glu Ala Phe Leu Cys Pro Gly 
225                 230                 235                 


<210>  2322
<211>  239
<212>  PRT
<213>  Homo Sapiens

<400>  2322

Met Trp Leu Pro Gln Leu Asp Leu Met Arg Val Ile Ser Ala Lys Ser 
1               5                   10                  15      


Gln Gly Tyr Ser Ile Val Thr Gln Ile Thr Gly Pro Thr Thr Val Asn 
            20                  25                  30          


Gly Leu Glu Arg Gly Ser Leu Thr Val Gln Cys Val Tyr Arg Ser Gly 
        35                  40                  45              


Trp Glu Thr Tyr Leu Lys Trp Trp Cys Arg Gly Ala Ile Trp Arg Asp 
    50                  55                  60                  


Cys Lys Ile Leu Val Lys Thr Ser Gly Ser Glu Gln Glu Val Lys Arg 
65                  70                  75                  80  


Asp Arg Val Ser Ile Lys Asp Asn Gln Lys Asn Arg Thr Phe Thr Val 
                85                  90                  95      


Thr Met Glu Asp Leu Met Lys Thr Asp Ala Asp Thr Tyr Trp Cys Gly 
            100                 105                 110         


Ile Glu Lys Thr Gly Asn Asp Leu Gly Val Thr Val Gln Val Thr Ile 
        115                 120                 125             


Asp Pro Ala Ser Thr Pro Ala Pro Thr Thr Pro Thr Ser Thr Thr Phe 
    130                 135                 140                 


Thr Ala Pro Val Thr Gln Glu Glu Thr Ser Ser Ser Pro Thr Leu Thr 
145                 150                 155                 160 


Gly His His Leu Asp Asn Arg His Lys Leu Leu Lys Leu Ser Val Leu 
                165                 170                 175     


Leu Pro Leu Ile Phe Thr Ile Leu Leu Leu Leu Leu Val Ala Ala Ser 
            180                 185                 190         


Leu Leu Ala Trp Arg Met Met Lys Tyr Gln Gln Lys Gly Thr Ala Ala 
        195                 200                 205             


Pro Gly Gly Arg Pro Leu Leu Cys Arg Pro Asp Pro Ala Ala Gly Arg 
    210                 215                 220                 


Asn Leu Pro Ala Lys Gly Tyr His Glu Ala Phe Leu Cys Pro Gly 
225                 230                 235                 


<210>  2323
<211>  273
<212>  PRT
<213>  Homo Sapiens

<400>  2323

Met Arg Leu Leu Val Leu Leu Trp Gly Cys Leu Leu Leu Pro Gly Tyr 
1               5                   10                  15      


Glu Ala Leu Glu Gly Pro Glu Glu Ile Ser Gly Phe Glu Gly Asp Thr 
            20                  25                  30          


Val Ser Leu Gln Cys Thr Tyr Arg Glu Glu Leu Arg Asp His Arg Lys 
        35                  40                  45              


Tyr Trp Cys Arg Lys Gly Gly Ile Leu Phe Ser Arg Cys Ser Gly Thr 
    50                  55                  60                  


Ile Tyr Ala Glu Glu Glu Gly Gln Glu Thr Met Lys Gly Arg Val Ser 
65                  70                  75                  80  


Ile Arg Asp Ser Arg Gln Glu Leu Ser Leu Ile Val Thr Leu Trp Asn 
                85                  90                  95      


Leu Thr Leu Gln Asp Ala Gly Glu Tyr Trp Cys Gly Val Glu Lys Arg 
            100                 105                 110         


Gly Pro Asp Glu Ser Leu Leu Ile Ser Leu Phe Val Phe Pro Ala Ser 
        115                 120                 125             


Pro Gly Leu Tyr Pro Ala Ala Thr Thr Ala Lys Gln Gly Lys Thr Gly 
    130                 135                 140                 


Ala Glu Ala Pro Pro Leu Pro Gly Thr Ser Gln Tyr Gly His Glu Arg 
145                 150                 155                 160 


Thr Ser Gln Tyr Thr Gly Thr Ser Pro His Pro Ala Thr Ser Pro Pro 
                165                 170                 175     


Ala Gly Ser Ser Arg Pro Pro Met Gln Leu Asp Ser Thr Ser Ala Glu 
            180                 185                 190         


Asp Thr Ser Pro Ala Leu Ser Ser Gly Ser Ser Lys Pro Arg Val Ser 
        195                 200                 205             


Ile Pro Met Val Arg Ile Leu Ala Pro Val Leu Val Leu Leu Ser Leu 
    210                 215                 220                 


Leu Ser Ala Ala Gly Leu Ile Ala Phe Cys Ser His Leu Leu Leu Trp 
225                 230                 235                 240 


Arg Lys Glu Ala Gln Gln Ala Thr Glu Thr Gln Arg Asn Glu Lys Phe 
                245                 250                 255     


Cys Leu Ser Arg Leu Asn Ser Leu Met Phe Ser Leu Ser Leu Pro Trp 
            260                 265                 270         


Leu 
    


<210>  2324
<211>  150
<212>  PRT
<213>  Homo Sapiens

<400>  2324

Met Arg Leu Leu Val Leu Leu Trp Gly Cys Leu Leu Leu Pro Gly Tyr 
1               5                   10                  15      


Glu Ala Leu Glu Gly Pro Glu Glu Ile Ser Gly Phe Glu Gly Asp Thr 
            20                  25                  30          


Val Ser Leu Gln Cys Thr Tyr Arg Glu Glu Leu Arg Asp His Arg Lys 
        35                  40                  45              


Tyr Trp Cys Arg Lys Gly Gly Ile Leu Phe Ser Arg Cys Ser Gly Thr 
    50                  55                  60                  


Ile Tyr Ala Glu Glu Glu Gly Gln Glu Thr Met Lys Gly Arg Val Ser 
65                  70                  75                  80  


Ile Arg Asp Ser Arg Gln Glu Leu Ser Leu Ile Val Thr Leu Trp Asn 
                85                  90                  95      


Leu Thr Leu Gln Asp Ala Gly Glu Tyr Trp Cys Gly Val Glu Lys Arg 
            100                 105                 110         


Gly Pro Asp Glu Ser Leu Leu Ile Ser Leu Phe Val Phe Pro Gly Asn 
        115                 120                 125             


Arg Tyr Leu Ser Phe Pro Arg Leu Gly Thr Gly Ala Ala Glu Gly Arg 
    130                 135                 140                 


Gly Arg Gly Gly Gly Ala 
145                 150 


<210>  2325
<211>  332
<212>  PRT
<213>  Homo Sapiens

<400>  2325

Met Arg Leu Leu Val Leu Leu Trp Gly Cys Leu Leu Leu Pro Gly Tyr 
1               5                   10                  15      


Glu Ala Leu Glu Gly Pro Glu Glu Ile Ser Gly Phe Glu Gly Asp Thr 
            20                  25                  30          


Val Ser Leu Gln Cys Thr Tyr Arg Glu Glu Leu Arg Asp His Arg Lys 
        35                  40                  45              


Tyr Trp Cys Arg Lys Gly Gly Ile Leu Phe Ser Arg Cys Ser Gly Thr 
    50                  55                  60                  


Ile Tyr Ala Glu Glu Glu Gly Gln Glu Thr Met Lys Gly Arg Val Ser 
65                  70                  75                  80  


Ile Arg Asp Ser Arg Gln Glu Leu Ser Leu Ile Val Thr Leu Trp Asn 
                85                  90                  95      


Leu Thr Leu Gln Asp Ala Gly Glu Tyr Trp Cys Gly Val Glu Lys Arg 
            100                 105                 110         


Gly Pro Asp Glu Ser Leu Leu Ile Ser Leu Phe Val Phe Pro Gly Pro 
        115                 120                 125             


Cys Cys Pro Pro Ser Pro Ser Pro Thr Phe Gln Pro Leu Ala Thr Thr 
    130                 135                 140                 


Arg Leu Gln Pro Lys Ala Lys Ala Gln Gln Thr Gln Pro Pro Gly Leu 
145                 150                 155                 160 


Thr Ser Pro Gly Leu Tyr Pro Ala Ala Thr Thr Ala Lys Gln Gly Lys 
                165                 170                 175     


Thr Gly Ala Glu Ala Pro Pro Leu Pro Gly Thr Ser Gln Tyr Gly His 
            180                 185                 190         


Glu Arg Thr Ser Gln Tyr Thr Gly Thr Ser Pro His Pro Ala Thr Ser 
        195                 200                 205             


Pro Pro Ala Gly Ser Ser Arg Pro Pro Met Gln Leu Asp Ser Thr Ser 
    210                 215                 220                 


Ala Glu Asp Thr Ser Pro Ala Leu Ser Ser Gly Ser Ser Lys Pro Arg 
225                 230                 235                 240 


Val Ser Ile Pro Met Val Arg Ile Leu Ala Pro Val Leu Val Leu Leu 
                245                 250                 255     


Ser Leu Leu Ser Ala Ala Gly Leu Ile Ala Phe Cys Ser His Leu Leu 
            260                 265                 270         


Leu Trp Arg Lys Glu Ala Gln Gln Ala Thr Glu Thr Gln Arg Asn Glu 
        275                 280                 285             


Lys Phe Cys Leu Ser Arg Leu Thr Ala Glu Glu Lys Glu Ala Pro Ser 
    290                 295                 300                 


Gln Ala Pro Glu Gly Asp Val Ile Ser Met Pro Pro Leu His Thr Ser 
305                 310                 315                 320 


Glu Glu Glu Leu Gly Phe Ser Lys Phe Val Ser Ala 
                325                 330         


<210>  2326
<211>  307
<212>  PRT
<213>  Homo Sapiens

<400>  2326

Met Arg Leu Leu Val Leu Leu Trp Gly Cys Leu Leu Leu Pro Gly Tyr 
1               5                   10                  15      


Glu Ala Leu Glu Gly Pro Glu Glu Ile Ser Gly Phe Glu Gly Asp Thr 
            20                  25                  30          


Val Ser Leu Gln Cys Thr Tyr Arg Glu Glu Leu Arg Asp His Arg Lys 
        35                  40                  45              


Tyr Trp Cys Arg Lys Gly Gly Ile Leu Phe Ser Arg Cys Ser Gly Thr 
    50                  55                  60                  


Ile Tyr Ala Glu Glu Glu Gly Gln Glu Thr Met Lys Gly Arg Val Ser 
65                  70                  75                  80  


Ile Arg Asp Ser Arg Gln Glu Leu Ser Leu Ile Val Thr Leu Trp Asn 
                85                  90                  95      


Leu Thr Leu Gln Asp Ala Gly Glu Tyr Trp Cys Gly Val Glu Lys Arg 
            100                 105                 110         


Gly Pro Asp Glu Ser Leu Leu Ile Ser Leu Phe Val Phe Pro Gly Pro 
        115                 120                 125             


Cys Cys Pro Pro Ser Pro Ser Pro Thr Phe Gln Pro Leu Ala Thr Thr 
    130                 135                 140                 


Arg Leu Gln Pro Lys Ala Lys Ala Gln Gln Thr Gln Pro Pro Gly Leu 
145                 150                 155                 160 


Thr Ser Pro Gly Leu Tyr Pro Ala Ala Thr Thr Ala Lys Gln Gly Lys 
                165                 170                 175     


Thr Gly Ala Glu Ala Pro Pro Leu Pro Gly Thr Ser Gln Tyr Gly His 
            180                 185                 190         


Glu Arg Thr Ser Gln Tyr Thr Gly Thr Ser Pro His Pro Ala Thr Ser 
        195                 200                 205             


Pro Pro Ala Gly Ser Ser Arg Pro Pro Met Gln Leu Asp Ser Thr Ser 
    210                 215                 220                 


Ala Glu Asp Thr Ser Pro Ala Leu Ser Ser Gly Ser Ser Lys Pro Arg 
225                 230                 235                 240 


Val Ser Ile Pro Met Val Arg Ile Leu Ala Pro Val Leu Val Leu Leu 
                245                 250                 255     


Ser Leu Leu Ser Ala Ala Gly Leu Ile Ala Phe Cys Ser His Leu Leu 
            260                 265                 270         


Leu Trp Arg Lys Glu Ala Gln Gln Ala Thr Glu Thr Gln Arg Asn Glu 
        275                 280                 285             


Lys Phe Cys Leu Ser Arg Leu Asn Ser Leu Met Phe Ser Leu Ser Leu 
    290                 295                 300                 


Pro Trp Leu 
305         


<210>  2327
<211>  233
<212>  PRT
<213>  Homo Sapiens

<400>  2327

Met Arg Leu Leu Val Leu Leu Trp Gly Cys Leu Leu Leu Pro Gly Tyr 
1               5                   10                  15      


Glu Ala Leu Glu Gly Pro Glu Glu Ile Ser Gly Phe Glu Gly Asp Thr 
            20                  25                  30          


Val Ser Leu Gln Cys Thr Tyr Arg Glu Glu Leu Arg Asp His Arg Lys 
        35                  40                  45              


Tyr Trp Cys Arg Lys Gly Gly Ile Leu Phe Ser Arg Cys Ser Gly Thr 
    50                  55                  60                  


Ile Tyr Ala Glu Glu Glu Gly Gln Glu Thr Met Lys Gly Arg Val Ser 
65                  70                  75                  80  


Ile Arg Asp Ser Arg Gln Glu Leu Ser Leu Ile Val Thr Leu Trp Asn 
                85                  90                  95      


Leu Thr Leu Gln Asp Ala Gly Glu Tyr Trp Cys Gly Val Glu Lys Arg 
            100                 105                 110         


Gly Pro Asp Glu Ser Leu Leu Ile Ser Leu Phe Val Phe Pro Gly Ser 
        115                 120                 125             


Ser Arg Pro Pro Met Gln Leu Asp Ser Thr Ser Ala Glu Asp Thr Ser 
    130                 135                 140                 


Pro Ala Leu Ser Ser Gly Ser Ser Lys Pro Arg Val Ser Ile Pro Met 
145                 150                 155                 160 


Val Arg Ile Leu Ala Pro Val Leu Val Leu Leu Ser Leu Leu Ser Ala 
                165                 170                 175     


Ala Gly Leu Ile Ala Phe Cys Ser His Leu Leu Leu Trp Arg Lys Glu 
            180                 185                 190         


Ala Gln Gln Ala Thr Glu Thr Gln Arg Asn Glu Lys Phe Cys Leu Ser 
        195                 200                 205             


Arg Leu Asn His Arg Thr Ser Glu Leu Asp Pro Asp Glu Ala Phe Glu 
    210                 215                 220                 


Ile Ser Ser Leu Thr Phe Leu Ser Val 
225                 230             


<210>  2328
<211>  222
<212>  PRT
<213>  Homo Sapiens

<400>  2328

Met Arg Leu Leu Val Leu Leu Trp Gly Cys Leu Leu Leu Pro Gly Tyr 
1               5                   10                  15      


Glu Ala Leu Glu Gly Pro Glu Glu Ile Ser Gly Phe Glu Gly Asp Thr 
            20                  25                  30          


Val Ser Leu Gln Cys Thr Tyr Arg Glu Glu Leu Arg Asp His Arg Lys 
        35                  40                  45              


Tyr Trp Cys Arg Lys Gly Gly Ile Leu Phe Ser Arg Cys Ser Gly Thr 
    50                  55                  60                  


Ile Tyr Ala Glu Glu Glu Gly Gln Glu Thr Met Lys Gly Arg Val Ser 
65                  70                  75                  80  


Ile Arg Asp Ser Arg Gln Glu Leu Ser Leu Ile Val Thr Leu Trp Asn 
                85                  90                  95      


Leu Thr Leu Gln Asp Ala Gly Glu Tyr Trp Cys Gly Val Glu Lys Arg 
            100                 105                 110         


Gly Pro Asp Glu Ser Leu Leu Ile Ser Leu Phe Val Phe Pro Gly Ser 
        115                 120                 125             


Ser Arg Pro Pro Met Gln Leu Asp Ser Thr Ser Ala Glu Asp Thr Ser 
    130                 135                 140                 


Pro Ala Leu Ser Ser Gly Ser Ser Lys Pro Arg Val Ser Ile Pro Met 
145                 150                 155                 160 


Val Arg Ile Leu Ala Pro Val Leu Val Leu Leu Ser Leu Leu Ser Ala 
                165                 170                 175     


Ala Gly Leu Ile Ala Phe Cys Ser His Leu Leu Leu Trp Arg Lys Glu 
            180                 185                 190         


Ala Gln Gln Ala Thr Glu Thr Gln Arg Asn Glu Lys Phe Cys Leu Ser 
        195                 200                 205             


Arg Leu Asn Ser Leu Met Phe Ser Leu Ser Leu Pro Trp Leu 
    210                 215                 220         


<210>  2329
<211>  98
<212>  PRT
<213>  Homo Sapiens

<400>  2329

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Cys Gln Ser Cys Val Glu Leu Asp Pro Ala Thr Val Ala 
            20                  25                  30          


Gly Ile Ile Val Thr Asp Val Ile Ala Thr Leu Leu Leu Ala Leu Gly 
        35                  40                  45              


Val Phe Cys Phe Ala Gly His Glu Thr Gly Arg Leu Ser Gly Ala Ala 
    50                  55                  60                  


Asp Thr Gln Ala Leu Leu Arg Asn Asp Gln Val Tyr Gln Pro Leu Arg 
65                  70                  75                  80  


Asp Arg Asp Asp Ala Gln Tyr Ser His Leu Gly Gly Asn Trp Ala Arg 
                85                  90                  95      


Asn Lys 
        


<210>  2330
<211>  171
<212>  PRT
<213>  Homo Sapiens

<400>  2330

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys 
                85                  90                  95      


Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His 
        115                 120                 125             


Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg 
    130                 135                 140                 


Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr 
145                 150                 155                 160 


Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
                165                 170     


<210>  2331
<211>  127
<212>  PRT
<213>  Homo Sapiens

<400>  2331

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Thr Ala Asp Thr Gln 
                85                  90                  95      


Ala Leu Leu Arg Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp 
            100                 105                 110         


Asp Ala Gln Tyr Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
        115                 120                 125         


<210>  2332
<211>  132
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2332

Xaa Ser Arg Cys Phe Ser Gly Pro Cys Ser Pro Tyr Ser Ser Ser Val 
1               5                   10                  15      


Val Trp Ile His Phe Gln Glu Val Ser Pro Phe Lys Ile Pro Ile Glu 
            20                  25                  30          


Glu Leu Glu Asp Arg Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp 
        35                  40                  45              


Val Glu Gly Thr Val Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp 
    50                  55                  60                  


Leu Gly Lys Arg Ile Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly 
65                  70                  75                  80  


Thr Asp Ile Tyr Lys Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg 
                85                  90                  95      


Thr Ala Asp Thr Gln Ala Leu Leu Arg Asn Asp Gln Val Tyr Gln Pro 
            100                 105                 110         


Leu Arg Asp Arg Asp Asp Ala Gln Tyr Ser His Leu Gly Gly Asn Trp 
        115                 120                 125             


Ala Arg Asn Lys 
    130         


<210>  2333
<211>  45
<212>  PRT
<213>  Homo Sapiens

<400>  2333

Met Asn Arg Gly Val Pro Phe Arg His Leu Leu Leu Val Leu Gln Leu 
1               5                   10                  15      


Ala Leu Leu Pro Ala Ala Thr Gln Gly Lys Lys Val Val Leu Gly Lys 
            20                  25                  30          


Lys Gly Asp Thr Val Glu Leu Thr Cys Thr Ala Ser Gln 
        35                  40                  45  


<210>  2334
<211>  458
<212>  PRT
<213>  Homo Sapiens

<400>  2334

Met Asn Arg Gly Val Pro Phe Arg His Leu Leu Leu Val Leu Gln Leu 
1               5                   10                  15      


Ala Leu Leu Pro Ala Ala Thr Gln Gly Lys Lys Val Val Leu Gly Lys 
            20                  25                  30          


Lys Gly Asp Thr Val Glu Leu Thr Cys Thr Ala Ser Gln Lys Lys Ser 
        35                  40                  45              


Ile Gln Phe His Trp Lys Asn Ser Asn Gln Ile Lys Ile Leu Gly Asn 
    50                  55                  60                  


Gln Gly Ser Phe Leu Thr Lys Gly Pro Ser Lys Leu Asn Asp Arg Ala 
65                  70                  75                  80  


Asp Ser Arg Arg Ser Leu Trp Asp Gln Gly Asn Phe Pro Leu Ile Ile 
                85                  90                  95      


Lys Asn Leu Lys Ile Glu Asp Ser Asp Thr Tyr Ile Cys Glu Val Glu 
            100                 105                 110         


Asp Gln Lys Glu Glu Val Gln Leu Leu Val Phe Gly Leu Thr Ala Asn 
        115                 120                 125             


Ser Asp Thr His Leu Leu Gln Gly Gln Ser Leu Thr Leu Thr Leu Glu 
    130                 135                 140                 


Ser Pro Pro Gly Ser Ser Pro Ser Val Gln Cys Arg Ser Pro Arg Gly 
145                 150                 155                 160 


Lys Asn Ile Gln Gly Gly Lys Thr Leu Ser Val Ser Gln Leu Glu Leu 
                165                 170                 175     


Gln Asp Ser Gly Thr Trp Thr Cys Thr Val Leu Gln Asn Gln Lys Lys 
            180                 185                 190         


Val Glu Phe Lys Ile Asp Ile Val Val Leu Ala Phe Gln Lys Ala Ser 
        195                 200                 205             


Ser Ile Val Tyr Lys Lys Glu Gly Glu Gln Val Glu Phe Ser Phe Pro 
    210                 215                 220                 


Leu Ala Phe Thr Val Glu Lys Leu Thr Gly Ser Gly Glu Leu Trp Trp 
225                 230                 235                 240 


Gln Ala Glu Arg Ala Ser Ser Ser Lys Ser Trp Ile Thr Phe Asp Leu 
                245                 250                 255     


Lys Asn Lys Glu Val Ser Val Lys Arg Val Thr Gln Asp Pro Lys Leu 
            260                 265                 270         


Gln Met Gly Lys Lys Leu Pro Leu His Leu Thr Leu Pro Gln Ala Leu 
        275                 280                 285             


Pro Gln Tyr Ala Gly Ser Gly Asn Leu Thr Leu Ala Leu Glu Ala Lys 
    290                 295                 300                 


Thr Gly Lys Leu His Gln Glu Val Asn Leu Val Val Met Arg Ala Thr 
305                 310                 315                 320 


Gln Leu Gln Lys Asn Leu Thr Cys Glu Val Trp Gly Pro Thr Ser Pro 
                325                 330                 335     


Lys Leu Met Leu Ser Leu Lys Leu Glu Asn Lys Glu Ala Lys Val Ser 
            340                 345                 350         


Lys Arg Glu Lys Ala Val Trp Val Leu Asn Pro Glu Ala Gly Met Trp 
        355                 360                 365             


Gln Cys Leu Leu Ser Asp Ser Gly Gln Val Leu Leu Glu Ser Asn Ile 
    370                 375                 380                 


Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met Ala Leu Ile 
385                 390                 395                 400 


Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile 
                405                 410                 415     


Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg Met 
            420                 425                 430         


Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro 
        435                 440                 445             


His Arg Phe Gln Lys Thr Cys Ser Pro Ile 
    450                 455             


<210>  2335
<211>  148
<212>  PRT
<213>  Homo Sapiens

<400>  2335

Met Asn Arg Gly Val Pro Phe Arg His Leu Leu Leu Val Leu Gln Leu 
1               5                   10                  15      


Gly Pro Ser Lys Leu Asn Asp Arg Ala Asp Ser Arg Arg Ser Leu Trp 
            20                  25                  30          


Asp Gln Gly Asn Phe Pro Leu Ile Ile Lys Asn Leu Lys Ile Glu Asp 
        35                  40                  45              


Ser Asp Thr Tyr Ile Cys Glu Val Glu Asp Gln Lys Glu Glu Val Gln 
    50                  55                  60                  


Leu Leu Val Phe Gly Leu Thr Ala Asn Ser Asp Thr His Leu Leu Gln 
65                  70                  75                  80  


Gly Gln Ser Leu Thr Leu Thr Leu Glu Ser Pro Pro Gly Ser Ser Pro 
                85                  90                  95      


Ser Val Gln Cys Arg Ser Pro Arg Gly Lys Asn Ile Gln Gly Gly Lys 
            100                 105                 110         


Thr Leu Ser Val Ser Gln Leu Glu Leu Gln Asp Ser Gly Thr Trp Thr 
        115                 120                 125             


Cys Thr Val Leu Gln Asn Gln Lys Lys Val Glu Phe Lys Ile Asp Ile 
    130                 135                 140                 


Val Val Leu Gly 
145             


<210>  2336
<211>  203
<212>  PRT
<213>  Homo Sapiens

<400>  2336

Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Pro Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Arg Ser Pro Gly Ser Ala Glu Ser Pro Gly Gly 
                165                 170                 175     


Asp Pro His His Leu Arg Asp Pro Val Cys His Pro Leu Gly Ala Gly 
            180                 185                 190         


Leu Tyr Gln Lys Gly Gly Gln Glu Ala Asn Gln 
        195                 200             


<210>  2337
<211>  277
<212>  PRT
<213>  Homo Sapiens

<400>  2337

Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Pro Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 
                165                 170                 175     


Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Gln Asp Arg Leu 
            180                 185                 190         


Arg Ala Leu Val Val Ile Pro Ile Ile Phe Gly Ile Leu Phe Ala Ile 
        195                 200                 205             


Leu Leu Val Leu Val Phe Ile Lys Lys Val Ala Lys Lys Pro Thr Asn 
    210                 215                 220                 


Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 
225                 230                 235                 240 


Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 
                245                 250                 255     


Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 
            260                 265                 270         


Val Gln Glu Arg Gln 
        275         


<210>  2338
<211>  151
<212>  PRT
<213>  Homo Sapiens

<400>  2338

Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Pro Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Asp Ile Cys Gln Pro His Phe Pro Lys Asp 
    130                 135                 140                 


Arg Gly Leu Asn Leu Leu Met 
145                 150     


<210>  2339
<211>  159
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2339

Xaa Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr Ala 
1               5                   10                  15      


Val His Pro Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu Ile 
            20                  25                  30          


Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val Ser 
        35                  40                  45              


Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu Ser 
    50                  55                  60                  


Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His Lys 
65                  70                  75                  80  


Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr Ser 
                85                  90                  95      


Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr Ser 
            100                 105                 110         


Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly Phe 
        115                 120                 125             


Gly Val Lys Gln Ile Ala Val Arg Pro Lys Thr Trp Leu Cys Asn Arg 
    130                 135                 140                 


Gln Ala Gln Thr Arg Leu Met Leu Ser Val Val Pro Arg Ile Gly 
145                 150                 155                 


<210>  2340
<211>  176
<212>  PRT
<213>  Homo Sapiens

<400>  2340

Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp Cys Thr 
1               5                   10                  15      


Ser Val Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln 
            20                  25                  30          


Ser Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro 
        35                  40                  45              


Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly 
    50                  55                  60                  


Arg Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly 
65                  70                  75                  80  


Tyr Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro 
                85                  90                  95      


Val Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val 
            100                 105                 110         


Gly Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp 
        115                 120                 125             


Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser 
    130                 135                 140                 


Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser 
145                 150                 155                 160 


Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala 
                165                 170                 175     


<210>  2341
<211>  269
<212>  PRT
<213>  Homo Sapiens

<400>  2341

Glu Asp Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro 
1               5                   10                  15      


Ile Thr Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys 
            20                  25                  30          


Gly Glu Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr 
        35                  40                  45              


Asp Asp Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser 
    50                  55                  60                  


Gly Gly Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp 
65                  70                  75                  80  


Glu Asp Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr 
                85                  90                  95      


Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys 
            100                 105                 110         


Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro 
        115                 120                 125             


Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His 
    130                 135                 140                 


Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser 
145                 150                 155                 160 


Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly 
                165                 170                 175     


His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Ile Thr 
            180                 185                 190         


Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp 
        195                 200                 205             


Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser 
    210                 215                 220                 


Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr 
225                 230                 235                 240 


Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg 
                245                 250                 255     


Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu 
            260                 265                 


<210>  2342
<211>  193
<212>  PRT
<213>  Homo Sapiens

<400>  2342

Ile Tyr Pro Ser Asn Pro Thr Asp Asp Asp Val Ser Ser Gly Ser Ser 
1               5                   10                  15      


Ser Glu Arg Ser Ser Thr Ser Gly Gly Tyr Ile Phe Tyr Thr Phe Ser 
            20                  25                  30          


Thr Val His Pro Ile Pro Asp Glu Asp Ser Pro Trp Ile Thr Asp Ser 
        35                  40                  45              


Thr Asp Arg Ile Pro Ala Thr Ser Thr Ser Ser Asn Thr Ile Ser Ala 
    50                  55                  60                  


Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg His Leu 
65                  70                  75                  80  


Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile Ser Ser 
                85                  90                  95      


Thr Asn Met Asp Ser Ser His Ser Ile Thr Leu Gln Pro Thr Ala Asn 
            100                 105                 110         


Pro Asn Thr Gly Leu Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser 
        115                 120                 125             


Met Thr Thr Gln Gln Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu 
    130                 135                 140                 


Gly Leu Glu Glu Asp Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser 
145                 150                 155                 160 


Ser Asn Arg Asn Asp Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser 
                165                 170                 175     


Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His 
            180                 185                 190         


Thr 
    


<210>  2343
<211>  78
<212>  PRT
<213>  Homo Sapiens

<400>  2343

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg 
65                  70                  75              


<210>  2344
<211>  493
<212>  PRT
<213>  Homo Sapiens

<400>  2344

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Asn Met 
    210                 215                 220                 


Asp Ser Ser His Ser Ile Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr 
225                 230                 235                 240 


Gly Leu Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr 
                245                 250                 255     


Gln Gln Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu 
            260                 265                 270         


Glu Asp Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg 
        275                 280                 285             


Asn Asp Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser 
    290                 295                 300                 


Thr Thr Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu 
305                 310                 315                 320 


Ser Arg Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly 
                325                 330                 335     


Val Thr Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser 
            340                 345                 350         


Leu Ser Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr 
        355                 360                 365             


Thr His Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly 
    370                 375                 380                 


Gly Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu 
385                 390                 395                 400 


Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala 
                405                 410                 415     


Val Cys Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys 
            420                 425                 430         


Leu Val Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser 
        435                 440                 445             


Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val 
    450                 455                 460                 


Asn Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu 
465                 470                 475                 480 


Thr Arg Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val 
                485                 490             


<210>  2345
<211>  429
<212>  PRT
<213>  Homo Sapiens

<400>  2345

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Asn Arg 
    210                 215                 220                 


Asn Asp Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser 
225                 230                 235                 240 


Thr Thr Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu 
                245                 250                 255     


Ser Arg Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly 
            260                 265                 270         


Val Thr Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser 
        275                 280                 285             


Leu Ser Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr 
    290                 295                 300                 


Thr His Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly 
305                 310                 315                 320 


Gly Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu 
                325                 330                 335     


Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala 
            340                 345                 350         


Val Cys Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys 
        355                 360                 365             


Leu Val Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser 
    370                 375                 380                 


Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val 
385                 390                 395                 400 


Asn Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu 
                405                 410                 415     


Thr Arg Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val 
            420                 425                 


<210>  2346
<211>  361
<212>  PRT
<213>  Homo Sapiens

<400>  2346

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Arg Asp 
    210                 215                 220                 


Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser 
225                 230                 235                 240 


Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr 
                245                 250                 255     


Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile 
            260                 265                 270         


Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala 
        275                 280                 285             


Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn 
    290                 295                 300                 


Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly 
305                 310                 315                 320 


Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser 
                325                 330                 335     


Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu 
            340                 345                 350         


Gln Asn Val Asp Met Lys Ile Gly Val 
        355                 360     


<210>  2347
<211>  340
<212>  PRT
<213>  Homo Sapiens

<400>  2347

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Arg His 
    210                 215                 220                 


Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly Pro Ile 
225                 230                 235                 240 


Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser Leu Leu 
                245                 250                 255     


Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser Arg Arg 
            260                 265                 270         


Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn Gly Ala 
        275                 280                 285             


Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser Lys Ser 
    290                 295                 300                 


Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr Pro Asp 
305                 310                 315                 320 


Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val Asp Met 
                325                 330                 335     


Lys Ile Gly Val 
            340 


<210>  2348
<211>  699
<212>  PRT
<213>  Homo Sapiens

<400>  2348

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Ser Thr 
    210                 215                 220                 


Ser Ser Asn Thr Ile Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu 
225                 230                 235                 240 


Asp Glu Arg Asp Arg His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp 
                245                 250                 255     


Asp Glu Asp Phe Ile Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe 
            260                 265                 270         


Asp His Thr Lys Gln Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His 
        275                 280                 285             


Ser Asn Pro Glu Val Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val 
    290                 295                 300                 


Asp Arg Asn Gly Thr Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala 
305                 310                 315                 320 


His Pro Pro Leu Ile His His Glu His His Glu Glu Glu Glu Thr Pro 
                325                 330                 335     


His Ser Thr Ser Thr Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu 
            340                 345                 350         


Thr Ala Thr Gln Lys Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly 
        355                 360                 365             


Tyr Arg Gln Thr Pro Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala 
    370                 375                 380                 


Ala Ala Ser Ala His Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro 
385                 390                 395                 400 


Ser Pro Glu Asp Ser Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His 
                405                 410                 415     


Pro Met Gly Arg Gly His Gln Ala Gly Arg Arg Met Asp Met Asp Ser 
            420                 425                 430         


Ser His Ser Ile Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu 
        435                 440                 445             


Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln 
    450                 455                 460                 


Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp 
465                 470                 475                 480 


Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp 
                485                 490                 495     


Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr 
            500                 505                 510         


Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg 
        515                 520                 525             


Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr 
    530                 535                 540                 


Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser 
545                 550                 555                 560 


Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His 
                565                 570                 575     


Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala 
            580                 585                 590         


Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu 
        595                 600                 605             


Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys 
    610                 615                 620                 


Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val 
625                 630                 635                 640 


Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu 
                645                 650                 655     


Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys 
            660                 665                 670         


Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg 
        675                 680                 685             


Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val 
    690                 695                 


<210>  2349
<211>  277
<212>  PRT
<213>  Homo Sapiens

<400>  2349

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Ala 
    210                 215                 220                 


Ser Ala His Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro 
225                 230                 235                 240 


Glu Asp Ser Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met 
                245                 250                 255     


Gly Arg Gly His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His 
            260                 265                 270         


Ser Ile Thr Leu Gln 
        275         


<210>  2350
<211>  742
<212>  PRT
<213>  Homo Sapiens

<400>  2350

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu 
    210                 215                 220                 


Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu 
225                 230                 235                 240 


Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn 
                245                 250                 255     


His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile 
            260                 265                 270         


Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg 
        275                 280                 285             


His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile 
    290                 295                 300                 


Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln 
305                 310                 315                 320 


Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val 
                325                 330                 335     


Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr 
            340                 345                 350         


Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile 
        355                 360                 365             


His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr 
    370                 375                 380                 


Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys 
385                 390                 395                 400 


Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro 
                405                 410                 415     


Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His 
            420                 425                 430         


Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser 
        435                 440                 445             


Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly 
    450                 455                 460                 


His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Ile Thr 
465                 470                 475                 480 


Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp 
                485                 490                 495     


Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser 
            500                 505                 510         


Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr 
        515                 520                 525             


Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg 
    530                 535                 540                 


Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr 
545                 550                 555                 560 


Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val 
                565                 570                 575     


Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly 
            580                 585                 590         


Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr 
        595                 600                 605             


Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp 
    610                 615                 620                 


Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly 
625                 630                 635                 640 


Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser 
                645                 650                 655     


Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser 
            660                 665                 670         


Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn 
        675                 680                 685             


Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser 
    690                 695                 700                 


Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr 
705                 710                 715                 720 


Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val 
                725                 730                 735     


Asp Met Lys Ile Gly Val 
            740         


<210>  2351
<211>  206
<212>  PRT
<213>  Homo Sapiens

<400>  2351

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Gly Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro 
            100                 105                 110         


Glu Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu 
        115                 120                 125             


Ala Val Cys Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys 
    130                 135                 140                 


Lys Leu Val Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro 
145                 150                 155                 160 


Ser Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu 
                165                 170                 175     


Val Asn Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp 
            180                 185                 190         


Glu Thr Arg Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val 
        195                 200                 205     


<210>  2352
<211>  139
<212>  PRT
<213>  Homo Sapiens

<400>  2352

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Ser Leu His 
65                  70                  75                  80  


Cys Ser Gln Gln Ser Lys Lys Val Trp Ala Glu Glu Lys Ala Ser Asp 
                85                  90                  95      


Gln Gln Trp Gln Trp Ser Cys Gly Gly Gln Lys Ala Lys Trp Thr Gln 
            100                 105                 110         


Arg Arg Gly Gln Gln Val Ser Gly Asn Gly Ala Phe Gly Glu Gln Gly 
        115                 120                 125             


Val Val Arg Asn Ser Arg Pro Val Tyr Asp Ser 
    130                 135                 


<210>  2353
<211>  80
<212>  PRT
<213>  Homo Sapiens

<400>  2353

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Ser Ser Thr 
65                  70                  75                  80  


<210>  2354
<211>  232
<212>  PRT
<213>  Homo Sapiens

<400>  2354

Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp Asp Val Ser Ser 
1               5                   10                  15      


Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly Tyr Ile Phe Tyr 
            20                  25                  30          


Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp Ser Pro Trp Ile 
        35                  40                  45              


Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Asn Met Asp Ser Ser His 
    50                  55                  60                  


Ser Ile Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu 
65                  70                  75                  80  


Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn 
                85                  90                  95      


Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp 
            100                 105                 110         


His Pro Thr Thr Ser Thr Leu Thr Ser Ser Arg Asp Gln Asp Thr Phe 
        115                 120                 125             


His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp Gly 
    130                 135                 140                 


His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly Pro 
145                 150                 155                 160 


Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser Leu 
                165                 170                 175     


Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser Arg 
            180                 185                 190         


Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn Gly 
        195                 200                 205             


Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser Lys 
    210                 215                 220                 


Ser Gln Glu Met Val His Leu Val 
225                 230         


<210>  2355
<211>  195
<212>  PRT
<213>  Homo Sapiens

<400>  2355

Arg Asn Gly Thr Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His 
1               5                   10                  15      


Pro Pro Leu Ile His His Glu His His Glu Glu Glu Glu Thr Pro His 
            20                  25                  30          


Ser Thr Ser Thr Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr 
        35                  40                  45              


Ala Thr Gln Lys Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr 
    50                  55                  60                  


Arg Gln Thr Pro Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala Asp 
65                  70                  75                  80  


Met Asp Ser Ser His Ser Ile Thr Leu Gln Pro Thr Ala Asn Pro Asn 
                85                  90                  95      


Thr Gly Leu Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr 
            100                 105                 110         


Thr Gln Gln Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu 
        115                 120                 125             


Glu Glu Asp Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn 
    130                 135                 140                 


Arg Asn Asp Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly 
145                 150                 155                 160 


Ser Thr Thr Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys 
                165                 170                 175     


Glu Ser Arg Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe 
            180                 185                 190         


Gly Val Thr 
        195 


<210>  2356
<211>  187
<212>  PRT
<213>  Homo Sapiens

<400>  2356

Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp Asp 
1               5                   10                  15      


Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly Tyr 
            20                  25                  30          


Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp Ser 
        35                  40                  45              


Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Ser Thr Ser 
    50                  55                  60                  


Ser Asn Thr Ile Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp 
65                  70                  75                  80  


Glu Arg Asp Arg His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp 
                85                  90                  95      


Glu Asp Phe Ile Ser Ser Thr Arg Asp Gln Asp Thr Phe His Pro Ser 
            100                 105                 110         


Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp Gly His Ser His 
        115                 120                 125             


Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr 
    130                 135                 140                 


Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu 
145                 150                 155                 160 


Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser Arg Arg Arg Cys 
                165                 170                 175     


Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly 
            180                 185         


<210>  2357
<211>  287
<212>  PRT
<213>  Homo Sapiens

<400>  2357

Arg Tyr Ser Ile Ser Arg Thr Glu Ala Ala Asp Leu Cys Lys Ala Phe 
1               5                   10                  15      


Asn Ser Thr Leu Pro Thr Met Ala Gln Met Glu Lys Ala Leu Ser Ile 
            20                  25                  30          


Gly Phe Glu Thr Cys Arg Tyr Gly Phe Ile Glu Gly His Val Val Ile 
        35                  40                  45              


Pro Arg Ile His Pro Asn Ser Ile Cys Ala Ala Asn Asn Thr Gly Val 
    50                  55                  60                  


Tyr Ile Leu Thr Ser Asn Thr Ser Gln Tyr Asp Thr Tyr Cys Phe Asn 
65                  70                  75                  80  


Ala Ser Ala Pro Pro Glu Glu Asp Cys Thr Ser Val Thr Asp Leu Pro 
                85                  90                  95      


Asn Ala Phe Asp Gly Pro Ile Thr Ile Thr Ile Val Asn Arg Asp Gly 
            100                 105                 110         


Thr Arg Tyr Val Gln Lys Gly Glu Tyr Arg Thr Asn Pro Glu Asp Ile 
        115                 120                 125             


Tyr Pro Ser Asn Pro Thr Asp Asp Asp Val Ser Ser Gly Ser Ser Ser 
    130                 135                 140                 


Glu Arg Ser Ser Thr Ser Gly Gly Asp Gln Asp Thr Phe His Pro Ser 
145                 150                 155                 160 


Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp Gly His Ser His 
                165                 170                 175     


Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr 
            180                 185                 190         


Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu 
        195                 200                 205             


Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser Arg Arg Arg Cys 
    210                 215                 220                 


Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn Gly Ala Val Glu 
225                 230                 235                 240 


Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu 
                245                 250                 255     


Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe 
            260                 265                 270         


Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val Asp Met Lys 
        275                 280                 285         


<210>  2358
<211>  82
<212>  PRT
<213>  Homo Sapiens

<400>  2358

Ser Lys His Asn Leu Trp Ser Tyr Lys Asp Thr Pro Asn Ser Arg Cys 
1               5                   10                  15      


Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn Gly Ala Val Glu 
            20                  25                  30          


Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu 
        35                  40                  45              


Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe 
    50                  55                  60                  


Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val Asp Met Lys Ile 
65                  70                  75                  80  


Gly Val 
        


<210>  2359
<211>  294
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2359

Xaa Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Arg Asp 
    210                 215                 220                 


Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser 
225                 230                 235                 240 


Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr 
                245                 250                 255     


Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile 
            260                 265                 270         


Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala 
        275                 280                 285             


Val Asn Ser Arg Arg Ser 
    290                 


<210>  2360
<211>  243
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2360

Xaa Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr Ile Thr Ile Val 
1               5                   10                  15      


Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu Tyr Arg Thr Asn 
            20                  25                  30          


Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp Asp Val Ser Ser 
        35                  40                  45              


Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly Tyr Ile Phe Tyr 
    50                  55                  60                  


Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp Ser Pro Trp Ile 
65                  70                  75                  80  


Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu Met Ser Thr Ser 
                85                  90                  95      


Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu Thr Trp Asp Trp 
            100                 105                 110         


Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn His Leu His Thr 
        115                 120                 125             


Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile Ser Ala Gly Trp 
    130                 135                 140                 


Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg His Leu Ser Phe 
145                 150                 155                 160 


Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile Ser Ser Thr Asn 
                165                 170                 175     


Met Asp Ser Ser His Ser Ile Thr Leu Gln Pro Thr Ala Asn Pro Asn 
            180                 185                 190         


Thr Gly Leu Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr 
        195                 200                 205             


Thr Gln Gln Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu 
    210                 215                 220                 


Glu Glu Asp Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn 
225                 230                 235                 240 


Arg Asn Asp 
            


<210>  2361
<211>  195
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2361

Xaa Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser 
1               5                   10                  15      


Ile Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr 
            20                  25                  30          


Ser Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu 
        35                  40                  45              


Asp Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile 
    50                  55                  60                  


Thr Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly 
65                  70                  75                  80  


Glu Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp 
                85                  90                  95      


Asp Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly 
            100                 105                 110         


Gly Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu 
        115                 120                 125             


Asp Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Lys 
    130                 135                 140                 


Gln Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu Glu 
145                 150                 155                 160 


Asp Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn 
                165                 170                 175     


Asp Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser Thr 
            180                 185                 190         


Thr Leu Leu 
        195 


<210>  2362
<211>  240
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2362

Xaa Leu Asn Ile Thr Cys Arg Phe Ala Gly Val Phe His Val Glu Lys 
1               5                   10                  15      


Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu Ala Ala Asp Leu Cys Lys 
            20                  25                  30          


Ala Phe Asn Ser Thr Leu Pro Thr Met Ala Gln Met Glu Lys Ala Leu 
        35                  40                  45              


Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly Phe Ile Glu Gly His Val 
    50                  55                  60                  


Val Ile Pro Arg Ile His Pro Asn Ser Ile Cys Ala Ala Asn Asn Thr 
65                  70                  75                  80  


Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser Gln Tyr Asp Thr Tyr Cys 
                85                  90                  95      


Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp Cys Thr Ser Val Thr Asp 
            100                 105                 110         


Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr Ile Thr Ile Val Asn Arg 
        115                 120                 125             


Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu Tyr Arg Thr Asn Pro Glu 
    130                 135                 140                 


Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp Asp Val Ser Ser Gly Ser 
145                 150                 155                 160 


Ser Ser Glu Arg Ser Ser Thr Ser Gly Asp Arg Asn Asp Val Thr Gly 
                165                 170                 175     


Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu 
            180                 185                 190         


Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile 
        195                 200                 205             


Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr 
    210                 215                 220                 


Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln 
225                 230                 235                 240 


<210>  2363
<211>  118
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2363

Xaa Pro Asp Glu Asp Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile 
1               5                   10                  15      


Pro Ala Thr Ser Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp 
            20                  25                  30          


Arg His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe 
        35                  40                  45              


Ile Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys 
    50                  55                  60                  


Gln Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu 
65                  70                  75                  80  


Val Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly 
                85                  90                  95      


Thr Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu 
            100                 105                 110         


Ile His His Glu His His 
        115             


<210>  2364
<211>  230
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2364

Xaa Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr 
1               5                   10                  15      


Gly Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser 
            20                  25                  30          


Ile Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr 
        35                  40                  45              


Ser Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu 
    50                  55                  60                  


Asp Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile 
65                  70                  75                  80  


Thr Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly 
                85                  90                  95      


Glu Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp 
            100                 105                 110         


Asp Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly 
        115                 120                 125             


Gly Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu 
    130                 135                 140                 


Asp Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Ile 
145                 150                 155                 160 


Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln Asn Gln Asp Trp 
                165                 170                 175     


Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val Leu Leu Gln Thr 
            180                 185                 190         


Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr Thr Ala Tyr Glu 
        195                 200                 205             


Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile His His Glu His 
    210                 215                 220                 


His Glu Glu Glu Glu Thr 
225                 230 


<210>  2365
<211>  183
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2365

Xaa Arg Thr Glu Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu 
1               5                   10                  15      


Pro Thr Met Ala Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr 
            20                  25                  30          


Cys Arg Tyr Gly Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His 
        35                  40                  45              


Pro Asn Ser Ile Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr 
    50                  55                  60                  


Ser Asn Thr Ser Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro 
65                  70                  75                  80  


Pro Glu Glu Asp Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp 
                85                  90                  95      


Gly Pro Ile Thr Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val 
            100                 105                 110         


Gln Lys Gly Glu Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn 
        115                 120                 125             


Pro Thr Asp Asp Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser 
    130                 135                 140                 


Thr Ser Gly Asp Met Asp Ser Ser His Ser Ile Thr Leu Gln Pro Thr 
145                 150                 155                 160 


Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp Arg Thr Gly Pro 
                165                 170                 175     


Leu Ser Met Thr Thr Gln Gln 
            180             


<210>  2366
<211>  191
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2366

Xaa Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln Asn Gln Asp 
1               5                   10                  15      


Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val Leu Leu Gln 
            20                  25                  30          


Thr Thr Thr Arg Met Thr Val Gln Ala Thr Pro Ser Ser Thr Thr Glu 
        35                  40                  45              


Glu Thr Ala Thr Gln Lys Glu Gln Trp Phe Gly Asn Arg Trp His Glu 
    50                  55                  60                  


Gly Tyr Arg Gln Thr Pro Lys Glu Asp Ser His Ser Thr Thr Gly Thr 
65                  70                  75                  80  


Ala Ala Ser Ala His Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro 
                85                  90                  95      


Ser Pro Glu Asp Ser Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His 
            100                 105                 110         


Pro Met Gly Arg Gly His Gln Ala Gly Arg Arg Met Asp Met Asp Ser 
        115                 120                 125             


Ser His Ser Ile Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu 
    130                 135                 140                 


Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln 
145                 150                 155                 160 


Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp 
                165                 170                 175     


Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn 
            180                 185                 190     


<210>  2367
<211>  243
<212>  PRT
<213>  Homo Sapiens

<400>  2367

Met Cys Ser Arg Gly Trp Asp Ser Cys Leu Ala Leu Glu Leu Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ser Leu Leu Val Thr Ser Ile Gln Gly His Leu Val His 
            20                  25                  30          


Met Thr Val Val Ser Gly Ser Asn Val Thr Leu Asn Ile Ser Glu Ser 
        35                  40                  45              


Leu Pro Glu Asn Tyr Lys Gln Leu Thr Trp Phe Tyr Thr Phe Asp Gln 
    50                  55                  60                  


Lys Ile Val Glu Trp Asp Ser Arg Lys Ser Lys Tyr Phe Glu Ser Lys 
65                  70                  75                  80  


Phe Lys Gly Arg Val Arg Leu Asp Pro Gln Ser Gly Ala Leu Tyr Ile 
                85                  90                  95      


Ser Lys Val Gln Lys Glu Asp Asn Ser Thr Tyr Ile Met Arg Val Leu 
            100                 105                 110         


Lys Lys Thr Gly Asn Glu Gln Glu Trp Lys Ile Lys Leu Gln Val Leu 
        115                 120                 125             


Asp Pro Val Pro Lys Pro Val Ile Lys Ile Glu Lys Ile Glu Asp Met 
    130                 135                 140                 


Asp Asp Asn Cys Tyr Leu Lys Leu Ser Cys Val Ile Pro Gly Glu Ser 
145                 150                 155                 160 


Val Asn Tyr Thr Trp Tyr Gly Asp Lys Arg Pro Phe Pro Lys Glu Leu 
                165                 170                 175     


Gln Asn Ser Val Leu Glu Thr Thr Leu Met Pro His Asn Tyr Ser Arg 
            180                 185                 190         


Cys Tyr Thr Cys Gln Val Ser Asn Ser Val Ser Ser Lys Asn Gly Thr 
        195                 200                 205             


Val Cys Leu Ser Pro Pro Cys Thr Leu Ala Arg Ser Phe Gly Val Glu 
    210                 215                 220                 


Trp Ile Ala Ser Trp Leu Val Val Thr Val Pro Thr Ile Leu Gly Leu 
225                 230                 235                 240 


Leu Leu Thr 
            


<210>  2368
<211>  252
<212>  PRT
<213>  Homo Sapiens

<400>  2368

Met Cys Ser Arg Gly Trp Asp Ser Cys Leu Ala Leu Glu Leu Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ser Leu Leu Val Thr Ser Ile Gln Gly His Leu Val His 
            20                  25                  30          


Met Thr Val Val Ser Gly Ser Asn Val Thr Leu Asn Ile Ser Glu Ser 
        35                  40                  45              


Leu Pro Glu Asn Tyr Lys Gln Leu Thr Trp Phe Tyr Thr Phe Asp Gln 
    50                  55                  60                  


Lys Ile Val Glu Trp Asp Ser Arg Lys Ser Lys Tyr Phe Glu Ser Lys 
65                  70                  75                  80  


Phe Lys Gly Arg Val Arg Leu Asp Pro Gln Ser Gly Ala Leu Tyr Ile 
                85                  90                  95      


Ser Lys Val Gln Lys Glu Asp Asn Ser Thr Tyr Ile Met Arg Val Leu 
            100                 105                 110         


Lys Lys Thr Gly Asn Glu Gln Glu Trp Lys Ile Lys Leu Gln Val Leu 
        115                 120                 125             


Asp Pro Val Pro Lys Pro Val Ile Lys Ile Glu Lys Ile Glu Asp Met 
    130                 135                 140                 


Asp Asp Asn Cys Tyr Leu Lys Leu Ser Cys Val Ile Pro Gly Glu Ser 
145                 150                 155                 160 


Val Asn Tyr Thr Trp Tyr Gly Asp Lys Arg Pro Phe Pro Lys Glu Leu 
                165                 170                 175     


Gln Asn Ser Val Leu Glu Thr Thr Leu Met Pro His Asn Tyr Ser Arg 
            180                 185                 190         


Cys Tyr Thr Cys Gln Val Ser Asn Ser Val Ser Ser Lys Asn Gly Thr 
        195                 200                 205             


Val Cys Leu Ser Pro Pro Cys Thr Leu Gly Lys Lys Asp Pro Trp Glu 
    210                 215                 220                 


Leu Arg Gly Ala Gln Gly Asn Trp Ser Cys Phe Glu Gln Arg Lys Ala 
225                 230                 235                 240 


Gly Gly Pro Ile Gln Pro Pro Cys Thr Val Trp Trp 
                245                 250         


<210>  2369
<211>  169
<212>  PRT
<213>  Homo Sapiens

<400>  2369

Met Cys Ser Arg Gly Trp Asp Ser Cys Leu Ala Leu Glu Leu Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ser Leu Leu Val Thr Ser Ile Gln Gly His Leu Val His 
            20                  25                  30          


Met Thr Val Val Ser Gly Ser Asn Val Thr Leu Asn Ile Ser Glu Ser 
        35                  40                  45              


Leu Pro Glu Asn Tyr Lys Gln Leu Thr Trp Phe Tyr Thr Phe Asp Gln 
    50                  55                  60                  


Lys Ile Val Glu Trp Asp Ser Arg Lys Ser Lys Tyr Phe Glu Ser Lys 
65                  70                  75                  80  


Phe Lys Gly Arg Val Arg Leu Asp Pro Gln Ser Gly Ala Leu Tyr Ile 
                85                  90                  95      


Ser Lys Val Gln Lys Glu Asp Asn Ser Thr Tyr Ile Met Arg Val Leu 
            100                 105                 110         


Lys Lys Thr Gly Asn Glu Gln Glu Trp Lys Ile Lys Leu Gln Val Leu 
        115                 120                 125             


Gly Glu Ser Gly Glu Pro Lys Ser Lys Ser Pro Leu Gln Trp Pro Gln 
    130                 135                 140                 


Met Asp His Cys Arg Ala Ser Trp Glu Ala Trp Gly Thr Leu Gly Glu 
145                 150                 155                 160 


Glu Glu Arg Lys Thr Ser Gly Gln Val 
                165                 


<210>  2370
<211>  165
<212>  PRT
<213>  Homo Sapiens

<400>  2370

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Cys Leu Gly Arg Leu Ser Trp Tyr Asp Pro Asp 
            20                  25                  30          


Phe Gln Ala Arg Leu Thr Arg Ser Asn Ser Lys Cys Gln Gly Gln Leu 
        35                  40                  45              


Glu Val Tyr Leu Lys Asp Gly Trp His Met Val Cys Ser Gln Ser Trp 
    50                  55                  60                  


Gly Arg Ser Ser Lys Gln Trp Glu Asp Pro Ser Gln Ala Ser Lys Val 
65                  70                  75                  80  


Cys Gln Arg Leu Asn Cys Gly Val Pro Leu Ser Leu Gly Pro Phe Leu 
                85                  90                  95      


Val Thr Tyr Thr Pro Gln Ser Ser Ile Ile Cys Tyr Gly Gln Leu Gly 
            100                 105                 110         


Ser Phe Ser Asn Cys Ser His Ser Arg Asn Asp Met Cys His Ser Leu 
        115                 120                 125             


Gly Leu Thr Cys Leu Glu Pro Gln Lys Thr Thr Pro Pro Thr Thr Arg 
    130                 135                 140                 


Pro Pro Pro Thr Thr Thr Pro Glu Pro Thr Ala Met Arg Pro Arg Thr 
145                 150                 155                 160 


Arg Pro Arg Thr Trp 
                165 


<210>  2371
<211>  495
<212>  PRT
<213>  Homo Sapiens

<400>  2371

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Cys Leu Gly Arg Leu Ser Trp Tyr Asp Pro Asp 
            20                  25                  30          


Phe Gln Ala Arg Leu Thr Arg Ser Asn Ser Lys Cys Gln Gly Gln Leu 
        35                  40                  45              


Glu Val Tyr Leu Lys Asp Gly Trp His Met Val Cys Ser Gln Ser Trp 
    50                  55                  60                  


Gly Arg Ser Ser Lys Gln Trp Glu Asp Pro Ser Gln Ala Ser Lys Val 
65                  70                  75                  80  


Cys Gln Arg Leu Asn Cys Gly Val Pro Leu Ser Leu Gly Pro Phe Leu 
                85                  90                  95      


Val Thr Tyr Thr Pro Gln Ser Ser Ile Ile Cys Tyr Gly Gln Leu Gly 
            100                 105                 110         


Ser Phe Ser Asn Cys Ser His Ser Arg Asn Asp Met Cys His Ser Leu 
        115                 120                 125             


Gly Leu Thr Cys Leu Glu Pro Gln Lys Thr Thr Pro Pro Thr Thr Arg 
    130                 135                 140                 


Pro Pro Pro Thr Thr Thr Pro Glu Pro Thr Ala Pro Pro Arg Leu Gln 
145                 150                 155                 160 


Leu Val Ala Gln Ser Gly Gly Gln His Cys Ala Gly Val Val Glu Phe 
                165                 170                 175     


Tyr Ser Gly Ser Leu Gly Gly Thr Ile Ser Tyr Glu Ala Gln Asp Lys 
            180                 185                 190         


Thr Gln Asp Leu Glu Asn Phe Leu Cys Asn Asn Leu Gln Cys Gly Ser 
        195                 200                 205             


Phe Leu Lys His Leu Pro Glu Thr Glu Ala Gly Arg Ala Gln Asp Pro 
    210                 215                 220                 


Gly Glu Pro Arg Glu His Gln Pro Leu Pro Ile Gln Trp Lys Ile Gln 
225                 230                 235                 240 


Asn Ser Ser Cys Thr Ser Leu Glu His Cys Phe Arg Lys Ile Lys Pro 
                245                 250                 255     


Gln Lys Ser Gly Arg Val Leu Ala Leu Leu Cys Ser Gly Phe Gln Pro 
            260                 265                 270         


Lys Val Gln Ser Arg Leu Val Gly Gly Ser Ser Ile Cys Glu Gly Thr 
        275                 280                 285             


Val Glu Val Arg Gln Gly Ala Gln Trp Ala Ala Leu Cys Asp Ser Ser 
    290                 295                 300                 


Ser Ala Arg Ser Ser Leu Arg Trp Glu Glu Val Cys Arg Glu Gln Gln 
305                 310                 315                 320 


Cys Gly Ser Val Asn Ser Tyr Arg Val Leu Asp Ala Gly Asp Pro Thr 
                325                 330                 335     


Ser Arg Gly Leu Phe Cys Pro His Gln Lys Leu Ser Gln Cys His Glu 
            340                 345                 350         


Leu Trp Glu Arg Asn Ser Tyr Cys Lys Lys Val Phe Val Thr Cys Gln 
        355                 360                 365             


Asp Pro Asn Pro Ala Gly Leu Ala Ala Gly Thr Val Ala Ser Ile Ile 
    370                 375                 380                 


Leu Ala Leu Val Leu Leu Val Val Leu Leu Val Val Cys Gly Pro Leu 
385                 390                 395                 400 


Ala Tyr Lys Lys Leu Val Lys Lys Phe Arg Gln Lys Lys Gln Arg Gln 
                405                 410                 415     


Trp Ile Gly Pro Thr Gly Met Asn Gln Asn Met Ser Phe His Arg Asn 
            420                 425                 430         


His Thr Ala Thr Val Arg Ser His Ala Glu Asn Pro Thr Ala Ser His 
        435                 440                 445             


Val Asp Asn Glu Tyr Ser Gln Pro Pro Arg Asn Ser His Leu Ser Ala 
    450                 455                 460                 


Tyr Pro Ala Leu Glu Gly Ala Leu His Arg Ser Ser Met Gln Pro Asp 
465                 470                 475                 480 


Asn Ser Ser Asp Ser Asp Tyr Asp Leu His Gly Ala Gln Arg Leu 
                485                 490                 495 


<210>  2372
<211>  317
<212>  PRT
<213>  Homo Sapiens

<400>  2372

Met Thr Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 
1               5                   10                  15      


Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Val 
            20                  25                  30          


Trp Gly Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala 
        35                  40                  45              


Leu Glu Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys 
    50                  55                  60                  


Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile 
65                  70                  75                  80  


Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Gln 
                85                  90                  95      


Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val 
            100                 105                 110         


Pro Gly Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr 
        115                 120                 125             


Gly Tyr Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly 
    130                 135                 140                 


Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr 
145                 150                 155                 160 


Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg 
                165                 170                 175     


Asp His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly 
            180                 185                 190         


Phe Thr Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp 
        195                 200                 205             


Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu 
    210                 215                 220                 


Thr Ser Lys Val Pro Pro Thr Val Gln Lys Pro Thr Thr Val Asn Val 
225                 230                 235                 240 


Pro Thr Thr Glu Val Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr 
                245                 250                 255     


Thr Thr Pro Asn Ala Gln Ala Thr Arg Ser Thr Pro Val Ser Arg Thr 
            260                 265                 270         


Thr Lys His Phe His Glu Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr 
        275                 280                 285             


Ser Gly Thr Thr Arg Leu Leu Ser Gly His Thr Cys Phe Thr Leu Thr 
    290                 295                 300                 


Gly Leu Leu Gly Thr Leu Val Thr Met Gly Leu Leu Thr 
305                 310                 315         


<210>  2373
<211>  440
<212>  PRT
<213>  Homo Sapiens

<400>  2373

Met Thr Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 
1               5                   10                  15      


Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Val 
            20                  25                  30          


Trp Gly Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala 
        35                  40                  45              


Leu Glu Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys 
    50                  55                  60                  


Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile 
65                  70                  75                  80  


Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg 
                85                  90                  95      


Ser Cys Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro 
            100                 105                 110         


Tyr Ile Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr Glu 
        115                 120                 125             


Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr 
    130                 135                 140                 


Cys Leu Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys Lys 
145                 150                 155                 160 


Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val 
                165                 170                 175     


Pro Gly Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr 
            180                 185                 190         


Gly Tyr Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly 
        195                 200                 205             


Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr 
    210                 215                 220                 


Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg 
225                 230                 235                 240 


Asp His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly 
                245                 250                 255     


Phe Thr Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp 
            260                 265                 270         


Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu 
        275                 280                 285             


Thr Ser Lys Val Pro Pro Thr Val Gln Lys Pro Thr Thr Val Asn Val 
    290                 295                 300                 


Pro Thr Thr Glu Val Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr 
305                 310                 315                 320 


Thr Thr Pro Asn Ala Gln Ala Thr Arg Ser Thr Pro Val Ser Arg Thr 
                325                 330                 335     


Thr Lys His Phe His Glu Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr 
            340                 345                 350         


Ser Gly Thr Thr Arg Leu Leu Ser Gly Ser Arg Pro Val Thr Gln Ala 
        355                 360                 365             


Gly Met Arg Trp Cys Asp Arg Ser Ser Leu Gln Ser Arg Thr Pro Gly 
    370                 375                 380                 


Phe Lys Arg Ser Phe His Phe Ser Leu Pro Ser Ser Trp Tyr Tyr Arg 
385                 390                 395                 400 


Ala His Val Phe His Val Asp Arg Phe Ala Trp Asp Ala Ser Asn His 
                405                 410                 415     


Gly Leu Ala Asp Leu Ala Lys Glu Glu Leu Arg Arg Lys Tyr Thr Gln 
            420                 425                 430         


Val Tyr Arg Leu Phe Leu Val Ser 
        435                 440 


<210>  2374
<211>  381
<212>  PRT
<213>  Homo Sapiens

<400>  2374

Met Thr Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 
1               5                   10                  15      


Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Val 
            20                  25                  30          


Trp Gly Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala 
        35                  40                  45              


Leu Glu Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys 
    50                  55                  60                  


Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile 
65                  70                  75                  80  


Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg 
                85                  90                  95      


Ser Cys Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro 
            100                 105                 110         


Tyr Ile Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr Glu 
        115                 120                 125             


Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr 
    130                 135                 140                 


Cys Leu Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys Lys 
145                 150                 155                 160 


Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val 
                165                 170                 175     


Pro Gly Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr 
            180                 185                 190         


Gly Tyr Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly 
        195                 200                 205             


Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr 
    210                 215                 220                 


Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg 
225                 230                 235                 240 


Asp His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly 
                245                 250                 255     


Phe Thr Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp 
            260                 265                 270         


Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu 
        275                 280                 285             


Thr Ser Lys Val Pro Pro Thr Val Gln Lys Pro Thr Thr Val Asn Val 
    290                 295                 300                 


Pro Thr Thr Glu Val Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr 
305                 310                 315                 320 


Thr Thr Pro Asn Ala Gln Ala Thr Arg Ser Thr Pro Val Ser Arg Thr 
                325                 330                 335     


Thr Lys His Phe His Glu Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr 
            340                 345                 350         


Ser Gly Thr Thr Arg Leu Leu Ser Gly His Thr Cys Phe Thr Leu Thr 
        355                 360                 365             


Gly Leu Leu Gly Thr Leu Val Thr Met Gly Leu Leu Thr 
    370                 375                 380     


<210>  2375
<211>  444
<212>  PRT
<213>  Homo Sapiens

<400>  2375

Met Thr Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 
1               5                   10                  15      


Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Val 
            20                  25                  30          


Trp Gly Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala 
        35                  40                  45              


Leu Glu Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys 
    50                  55                  60                  


Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile 
65                  70                  75                  80  


Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg 
                85                  90                  95      


Ser Cys Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro 
            100                 105                 110         


Tyr Ile Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr Glu 
        115                 120                 125             


Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr 
    130                 135                 140                 


Cys Leu Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys Lys 
145                 150                 155                 160 


Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val 
                165                 170                 175     


Pro Gly Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr 
            180                 185                 190         


Gly Tyr Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly 
        195                 200                 205             


Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr 
    210                 215                 220                 


Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg 
225                 230                 235                 240 


Asp His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly 
                245                 250                 255     


Phe Thr Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp 
            260                 265                 270         


Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu 
        275                 280                 285             


Thr Ser Lys Val Pro Pro Thr Val Gln Lys Pro Thr Thr Val Asn Val 
    290                 295                 300                 


Pro Thr Thr Glu Val Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr 
305                 310                 315                 320 


Thr Thr Pro Asn Ala Gln Ala Thr Arg Ser Thr Pro Val Ser Arg Thr 
                325                 330                 335     


Thr Lys His Phe His Glu Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr 
            340                 345                 350         


Ser Gly Thr Thr Arg Leu Leu Ser Gly Ser Arg Pro Val Thr Gln Ala 
        355                 360                 365             


Gly Met Arg Trp Cys Asp Arg Ser Ser Leu Gln Ser Arg Thr Pro Gly 
    370                 375                 380                 


Phe Lys Arg Ser Phe His Phe Ser Leu Pro Ser Ser Trp Tyr Tyr Arg 
385                 390                 395                 400 


Cys Val Pro Arg His Pro Ala Lys Phe Leu Lys Phe Ile Phe Cys Arg 
                405                 410                 415     


Asp Arg Ile Phe Leu Cys Cys Pro Gly Trp Phe Gln Thr Pro Gly Arg 
            420                 425                 430         


Lys Arg Phe Phe Arg Pro Pro Lys Thr Leu Arg Leu 
        435                 440                 


<210>  2376
<211>  550
<212>  PRT
<213>  Homo Sapiens

<400>  2376

Met Thr Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 
1               5                   10                  15      


Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Val 
            20                  25                  30          


Trp Gly Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala 
        35                  40                  45              


Leu Glu Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys 
    50                  55                  60                  


Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile 
65                  70                  75                  80  


Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg 
                85                  90                  95      


Ser Cys Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro 
            100                 105                 110         


Tyr Ile Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr Glu 
        115                 120                 125             


Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr 
    130                 135                 140                 


Cys Leu Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys Lys 
145                 150                 155                 160 


Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val 
                165                 170                 175     


Pro Gly Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr 
            180                 185                 190         


Gly Tyr Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly 
        195                 200                 205             


Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr 
    210                 215                 220                 


Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg 
225                 230                 235                 240 


Asp His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly 
                245                 250                 255     


Phe Thr Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp 
            260                 265                 270         


Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu 
        275                 280                 285             


Thr Ser Lys Val Pro Pro Thr Val Gln Lys Pro Thr Thr Val Asn Val 
    290                 295                 300                 


Pro Thr Thr Glu Val Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr 
305                 310                 315                 320 


Thr Thr Pro Asn Ala Gln Gly Thr Glu Thr Pro Ser Val Leu Gln Lys 
                325                 330                 335     


His Thr Thr Glu Asn Val Ser Ala Thr Arg Thr Pro Pro Thr Pro Gln 
            340                 345                 350         


Lys Pro Thr Thr Val Asn Val Pro Ala Thr Ile Val Thr Pro Thr Pro 
        355                 360                 365             


Lys Pro Thr Thr Ile Asn Val Pro Ala Thr Gly Val Ser Ser Thr Pro 
    370                 375                 380                 


Gln Arg His Thr Ile Val Asn Val Ser Ala Thr Gly Thr Leu Pro Thr 
385                 390                 395                 400 


Leu Gln Lys Pro Thr Arg Ala Asn Asp Ser Ala Thr Lys Ser Pro Ala 
                405                 410                 415     


Ala Ala Gln Thr Ser Phe Ile Ser Lys Thr Leu Ser Thr Lys Thr Pro 
            420                 425                 430         


Ser Ala Ala Gln Asn Pro Met Met Thr Asn Ala Ser Ala Thr Gln Ala 
        435                 440                 445             


Thr Leu Thr Ala Gln Lys Phe Thr Thr Ala Lys Val Ala Phe Thr Gln 
    450                 455                 460                 


Ser Pro Ser Ala Ala Arg Lys Ser Thr Asn Val His Ser Pro Val Thr 
465                 470                 475                 480 


Asn Gly Leu Lys Ser Thr Gln Arg Phe Pro Ser Ala His Ile Thr Ala 
                485                 490                 495     


Thr Arg Ser Thr Pro Val Ser Arg Thr Thr Lys His Phe His Glu Thr 
            500                 505                 510         


Thr Pro Asn Lys Gly Ser Gly Thr Thr Ser Gly Thr Thr Arg Leu Leu 
        515                 520                 525             


Ser Gly His Thr Cys Phe Thr Leu Thr Gly Leu Leu Gly Thr Leu Val 
    530                 535                 540                 


Thr Met Gly Leu Leu Thr 
545                 550 


<210>  2377
<211>  439
<212>  PRT
<213>  Homo Sapiens

<400>  2377

Met Thr Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 
1               5                   10                  15      


Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Val 
            20                  25                  30          


Trp Gly Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala 
        35                  40                  45              


Leu Glu Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys 
    50                  55                  60                  


Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile 
65                  70                  75                  80  


Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg 
                85                  90                  95      


Ser Cys Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro 
            100                 105                 110         


Tyr Ile Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr Glu 
        115                 120                 125             


Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr 
    130                 135                 140                 


Cys Leu Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys Lys 
145                 150                 155                 160 


Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val 
                165                 170                 175     


Pro Gly Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr 
            180                 185                 190         


Gly Tyr Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly 
        195                 200                 205             


Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr 
    210                 215                 220                 


Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg 
225                 230                 235                 240 


Asp His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly 
                245                 250                 255     


Phe Thr Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp 
            260                 265                 270         


Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu 
        275                 280                 285             


Thr Ser Lys Val Pro Pro Thr Val Gln Lys Pro Thr Thr Val Asn Val 
    290                 295                 300                 


Pro Thr Thr Glu Val Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr 
305                 310                 315                 320 


Thr Thr Pro Asn Ala Gln Ala Thr Arg Ser Thr Pro Val Ser Arg Thr 
                325                 330                 335     


Thr Lys His Phe His Glu Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr 
            340                 345                 350         


Ser Gly Thr Thr Arg Leu Leu Ser Glu Thr Val Phe His Arg Val Ile 
        355                 360                 365             


Gln Asp Gly Leu Asp Leu Leu Ala Ser Arg Ser Ala Cys Leu Gly Leu 
    370                 375                 380                 


Pro Lys Cys Trp Asp Tyr Arg Arg Glu Pro Pro His Leu Ala Arg Ala 
385                 390                 395                 400 


His Val Phe His Val Asp Arg Phe Ala Trp Asp Ala Ser Asn His Gly 
                405                 410                 415     


Leu Ala Asp Leu Ala Lys Glu Glu Leu Arg Arg Lys Tyr Thr Gln Val 
            420                 425                 430         


Tyr Arg Leu Phe Leu Val Ser 
        435                 


<210>  2378
<211>  384
<212>  PRT
<213>  Homo Sapiens

<400>  2378

Met Thr Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 
1               5                   10                  15      


Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Val 
            20                  25                  30          


Trp Gly Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala 
        35                  40                  45              


Leu Glu Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys 
    50                  55                  60                  


Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile 
65                  70                  75                  80  


Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg 
                85                  90                  95      


Ser Cys Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro 
            100                 105                 110         


Tyr Ile Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr Glu 
        115                 120                 125             


Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr 
    130                 135                 140                 


Cys Leu Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys Lys 
145                 150                 155                 160 


Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val 
                165                 170                 175     


Pro Gly Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr 
            180                 185                 190         


Gly Tyr Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly 
        195                 200                 205             


Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr 
    210                 215                 220                 


Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg 
225                 230                 235                 240 


Asp His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly 
                245                 250                 255     


Phe Thr Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp 
            260                 265                 270         


Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu 
        275                 280                 285             


Thr Ser Lys Val Pro Pro Thr Val Gln Lys Pro Thr Thr Val Asn Val 
    290                 295                 300                 


Pro Thr Thr Glu Val Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr 
305                 310                 315                 320 


Thr Thr Pro Asn Ala Gln Ala Thr Arg Ser Thr Pro Val Ser Arg Thr 
                325                 330                 335     


Thr Lys His Phe His Glu Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr 
            340                 345                 350         


Ser Gly Thr Thr Arg Leu Leu Ser Ala Leu Gln Val Arg Pro Phe Glu 
        355                 360                 365             


Val Ser Gly Ser Ser His Ile Ser Ser Lys Lys Met Met Cys Ile Leu 
    370                 375                 380                 


<210>  2379
<211>  326
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2379

Xaa Ala Ala Leu Pro Leu Leu Gly Glu Leu Pro Arg Leu Leu Leu Leu 
1               5                   10                  15      


Val Leu Leu Cys Leu Pro Ala Val Trp Glu Ser Ser Arg Val Glu His 
            20                  25                  30          


Thr Met Leu Gln Thr Cys Met Ser Ser Leu Ser Gly Asp Cys Gly Leu 
        35                  40                  45              


Pro Pro Asp Val Pro Asn Ala Gln Pro Ala Leu Glu Gly Arg Thr Ser 
    50                  55                  60                  


Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys Cys Glu Glu Ser Phe Val 
65                  70                  75                  80  


Lys Ile Pro Gly Glu Lys Asp Ser Val Ile Cys Leu Lys Gly Ser Gln 
                85                  90                  95      


Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg Ser Cys Glu Val Pro Thr 
            100                 105                 110         


Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro Tyr Ile Thr Gln Asn Tyr 
        115                 120                 125             


Phe Pro Val Gly Thr Val Val Glu Tyr Glu Cys Arg Pro Gly Tyr Arg 
    130                 135                 140                 


Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr Cys Leu Gln Asn Leu Lys 
145                 150                 155                 160 


Trp Ser Thr Ala Val Glu Phe Cys Lys Lys Lys Ser Cys Pro Asn Pro 
                165                 170                 175     


Gly Glu Ile Arg Asn Gly Gln Ile Asp Val Pro Gly Gly Ile Leu Phe 
            180                 185                 190         


Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr Gly Tyr Lys Leu Phe Gly 
        195                 200                 205             


Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly Ser Ser Val Gln Trp Ser 
    210                 215                 220                 


Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr Cys Pro Ala Pro Pro Gln 
225                 230                 235                 240 


Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg Asp His Tyr Gly Tyr Arg 
                245                 250                 255     


Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly Phe Thr Met Ile Gly Glu 
            260                 265                 270         


His Ser Ile Tyr Cys Thr Val Asn Asn Asp Glu Gly Glu Trp Ser Gly 
        275                 280                 285             


Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu Thr Ser Lys Val Pro Pro 
    290                 295                 300                 


Thr Val Gln Lys Pro Thr Thr Val Asn Val Pro Thr Thr Glu Val Ser 
305                 310                 315                 320 


Pro Thr Ser Gln Lys Thr 
                325     


<210>  2380
<211>  268
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2380

Xaa Gly Glu Ile Arg Asn Gly Gln Ile Asp Val Pro Gly Gly Ile Leu 
1               5                   10                  15      


Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr Gly Tyr Lys Leu Phe 
            20                  25                  30          


Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly Ser Ser Val Gln Trp 
        35                  40                  45              


Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr Cys Pro Ala Pro Pro 
    50                  55                  60                  


Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg Asp His Tyr Gly Tyr 
65                  70                  75                  80  


Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly Phe Thr Met Ile Gly 
                85                  90                  95      


Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp Glu Gly Glu Trp Ser 
            100                 105                 110         


Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu Thr Ser Lys Val Pro 
        115                 120                 125             


Pro Thr Val Gln Lys Pro Thr Thr Val Asn Val Pro Thr Thr Glu Val 
    130                 135                 140                 


Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr Thr Thr Pro Asn Ala 
145                 150                 155                 160 


Gln Ala Thr Arg Ser Thr Pro Val Ser Arg Thr Thr Lys His Phe His 
                165                 170                 175     


Glu Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr Ser Gly Thr Thr Arg 
            180                 185                 190         


Leu Leu Ser Glu Ser Tyr Ser Val Thr Gln Ala Gly Val Trp Trp Cys 
        195                 200                 205             


Asp Leu Arg Ser Leu Gln Pro Leu Pro Pro Glu Phe Lys Gln Phe Ser 
    210                 215                 220                 


Cys Leu Ser Leu Arg Ser Ser Trp Asp Tyr Arg Ile Ile Thr Gly His 
225                 230                 235                 240 


Leu Leu Pro Gly Asp Phe Ser Val Pro Ser Thr Ile Val Asp Gly Ile 
                245                 250                 255     


Tyr Phe Pro Thr Pro Leu Ser Pro Phe Phe Val Gly 
            260                 265             


<210>  2381
<211>  194
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2381

Xaa Arg Glu Ile Tyr Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile 
1               5                   10                  15      


Ile Gln Gly Glu Arg Asp His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr 
            20                  25                  30          


Ala Cys Asn Lys Gly Phe Thr Met Ile Gly Glu His Ser Ile Tyr Cys 
        35                  40                  45              


Thr Val Asn Asn Asp Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys 
    50                  55                  60                  


Arg Gly Lys Ser Leu Thr Ser Lys Val Pro Pro Thr Val Gln Lys Pro 
65                  70                  75                  80  


Thr Thr Val Asn Val Pro Thr Thr Glu Val Ser Pro Thr Ser Gln Lys 
                85                  90                  95      


Thr Thr Thr Lys Thr Thr Thr Pro Asn Ala Gln Ala Thr Arg Ser Thr 
            100                 105                 110         


Pro Val Ser Arg Thr Thr Lys His Phe His Glu Thr Thr Pro Asn Lys 
        115                 120                 125             


Gly Ser Gly Thr Thr Ser Gly Thr Thr Arg Leu Leu Ser Glu Ser Tyr 
    130                 135                 140                 


Ser Val Thr Gln Ala Gly Val Trp Trp Cys Asp Leu Arg Ser Leu Gln 
145                 150                 155                 160 


Pro Leu Pro Pro Glu Phe Lys Gln Phe Ser Cys Leu Ser Leu Arg Ser 
                165                 170                 175     


Ser Trp Asp Tyr Arg Ile Glu Ala Ala Asp Leu His Ser Glu Cys Tyr 
            180                 185                 190         


Ser Ser 
        


<210>  2382
<211>  61
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2382

Xaa Thr Thr Glu Val Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr 
1               5                   10                  15      


Thr Thr Pro Asn Ala Gln Ala Thr Arg Ser Thr Pro Val Ser Arg Thr 
            20                  25                  30          


Thr Lys His Phe His Glu Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr 
        35                  40                  45              


Ser Gly Thr Thr Arg Leu Leu Ser Ala Ile Phe Ser Cys 
    50                  55                  60      


<210>  2383
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  2383

Met Gly Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Ala Val Phe Cys His Ser Gly His Ser Leu Gln Cys Tyr Asn Cys Pro 
            20                  25                  30          


Asn Pro Thr Ala Asp Cys Lys Thr Ala Val Asn Cys Ser Ser Asp Phe 
        35                  40                  45              


Asp Ala Cys Leu Ile Thr Lys Ala Glu Leu Gly Tyr His Tyr Val Ala 
    50                  55                  60                  


Gln Ala Gly Arg Arg Gln Ser Ser His Phe Ser Leu Leu Lys Cys Trp 
65                  70                  75                  80  


Asp Tyr Arg Cys Glu Pro Ser His Trp Pro His Cys Pro Tyr Phe Asn 
                85                  90                  95      


Trp Gly Tyr Lys Cys Ile Thr Ser Val Gly Ser Leu Ser Ile Ala Ile 
            100                 105                 110         


Ser Thr Thr Ser Gln Pro Ala 
        115                 


<210>  2384
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  2384

Met Gly Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Ala Val Phe Cys His Ser Gly His Ser Leu Gln Cys Tyr Asn Cys Pro 
            20                  25                  30          


Asn Pro Thr Ala Asp Cys Lys Thr Ala Val Asn Cys Ser Ser Asp Phe 
        35                  40                  45              


Asp Ala Cys Leu Ile Thr Lys Ala Glu Leu Gly Tyr His Tyr Val Ala 
    50                  55                  60                  


Gln Ala Gly Arg Arg Gln Ser Ser His Phe Ser Leu Leu Lys Cys Trp 
65                  70                  75                  80  


Asp Tyr Arg Cys Glu Pro Ser His Trp Pro His Cys Pro Tyr Phe Asn 
                85                  90                  95      


Trp Gly Tyr Lys Cys Ile Thr Ser Val Gly Ser Leu Ser Ile Ala Ile 
            100                 105                 110         


Ser Thr Thr Ser Gln Pro Ala 
        115                 


<210>  2385
<211>  120
<212>  PRT
<213>  Homo Sapiens

<400>  2385

Met Gly Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Ala Val Phe Cys His Ser Gly His Ser Leu Gln Cys Tyr Asn Cys Pro 
            20                  25                  30          


Asn Pro Thr Ala Asp Cys Lys Thr Ala Val Asn Cys Ser Ser Asp Phe 
        35                  40                  45              


Asp Ala Cys Leu Ile Thr Lys Ala Gly Leu Gln Val Tyr Asn Lys Cys 
    50                  55                  60                  


Trp Lys Phe Glu His Cys Asn Phe Asn Asp Val Thr Thr Arg Leu Arg 
65                  70                  75                  80  


Glu Asn Glu Leu Thr Tyr Tyr Cys Cys Lys Lys Asp Leu Cys Asn Phe 
                85                  90                  95      


Asn Glu Gln Leu Glu Asn Gly Gly Thr Ser Leu Ser Glu Lys Thr Val 
            100                 105                 110         


Leu Leu Leu Val Thr Pro Phe Leu 
        115                 120 


<210>  2386
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  2386

Met Gly Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Ala Val Phe Cys His Ser Gly His Ser Leu Gln Cys Tyr Asn Cys Pro 
            20                  25                  30          


Asn Pro Thr Ala Asp Cys Lys Thr Ala Val Asn Cys Ser Ser Asp Phe 
        35                  40                  45              


Asp Ala Cys Leu Ile Thr Lys Ala Gly Leu Gln Val Tyr Asn Lys Cys 
    50                  55                  60                  


Trp Lys Phe Glu His Cys Asn Phe Asn Asp Val Thr Thr Arg Leu Arg 
65                  70                  75                  80  


Glu Asn Glu Leu Thr Tyr Tyr Cys Cys Lys Lys Asp Leu Cys Asn Phe 
                85                  90                  95      


Asn Glu Gln Leu Glu Asn Gly Gly Thr Ser Leu Ser Glu Lys Thr Val 
            100                 105                 110         


Leu Leu Leu Val Thr Pro Phe Leu Ala Ala Ala Trp Ser Leu His Pro 
        115                 120                 125             


<210>  2387
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  2387

Met Gly Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Ala Val Phe Cys His Ser Gly His Ser Leu Gln Cys Tyr Asn Cys Pro 
            20                  25                  30          


Asn Pro Thr Ala Asp Cys Lys Thr Ala Val Asn Cys Ser Ser Asp Phe 
        35                  40                  45              


Asp Ala Cys Leu Ile Thr Lys Ala Gly Leu Gln Val Tyr Asn Lys Cys 
    50                  55                  60                  


Trp Lys Phe Glu His Cys Asn Phe Asn Asp Val Thr Thr Arg Leu Arg 
65                  70                  75                  80  


Glu Asn Glu Leu Thr Tyr Tyr Cys Cys Lys Lys Asp Leu Cys Asn Phe 
                85                  90                  95      


Asn Glu Gln Leu Glu Asn Gly Gly Thr Ser Leu Ser Glu Lys Thr Val 
            100                 105                 110         


Leu Leu Leu Val Thr Pro Phe Leu Ala Ala Ala Trp Ser Leu His Pro 
        115                 120                 125             


<210>  2388
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  2388

Met Gly Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Ala Val Phe Cys His Ser Gly His Ser Leu Gln Cys Tyr Asn Cys Pro 
            20                  25                  30          


Asn Pro Thr Ala Asp Cys Lys Thr Ala Val Asn Cys Ser Ser Asp Phe 
        35                  40                  45              


Asp Ala Cys Leu Ile Thr Lys Ala Gly Leu Gln Val Tyr Asn Lys Cys 
    50                  55                  60                  


Trp Lys Phe Glu His Cys Asn Phe Asn Asp Val Thr Thr Arg Leu Arg 
65                  70                  75                  80  


Glu Asn Glu Leu Thr Tyr Tyr Cys Cys Lys Lys Asp Leu Cys Asn Phe 
                85                  90                  95      


Asn Glu Gln Leu Glu Asn Gly Gly Thr Ser Leu Ser Glu Lys Thr Val 
            100                 105                 110         


Leu Leu Leu Val Thr Pro Phe Leu Ala Ala Ala Trp Ser Leu His Pro 
        115                 120                 125             


<210>  2389
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  2389

Met Gly Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Ala Val Phe Cys His Ser Gly His Ser Leu Gln Cys Tyr Asn Cys Pro 
            20                  25                  30          


Asn Pro Thr Ala Asp Cys Lys Thr Ala Val Asn Cys Ser Ser Asp Phe 
        35                  40                  45              


Asp Ala Cys Leu Ile Thr Lys Ala Gly Leu Gln Val Tyr Asn Lys Cys 
    50                  55                  60                  


Trp Lys Phe Glu His Cys Asn Phe Asn Asp Val Thr Thr Arg Leu Arg 
65                  70                  75                  80  


Glu Asn Glu Leu Thr Tyr Tyr Cys Cys Lys Lys Asp Leu Cys Asn Phe 
                85                  90                  95      


Asn Glu Gln Leu Glu Asn Gly Gly Thr Ser Leu Ser Glu Lys Thr Val 
            100                 105                 110         


Leu Leu Leu Val Thr Pro Phe Leu Ala Ala Ala Trp Ser Leu His Pro 
        115                 120                 125             


<210>  2390
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  2390

Met Gly Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Ala Val Phe Cys His Ser Gly His Ser Leu Gln Cys Tyr Asn Cys Pro 
            20                  25                  30          


Asn Pro Thr Ala Asp Cys Lys Thr Ala Val Asn Cys Ser Ser Asp Phe 
        35                  40                  45              


Asp Ala Cys Leu Ile Thr Lys Ala Gly Leu Gln Val Tyr Asn Lys Cys 
    50                  55                  60                  


Trp Lys Phe Glu His Cys Asn Phe Asn Asp Val Thr Thr Arg Leu Arg 
65                  70                  75                  80  


Glu Asn Glu Leu Thr Tyr Tyr Cys Cys Lys Lys Asp Leu Cys Asn Phe 
                85                  90                  95      


Asn Glu Gln Leu Glu Asn Gly Gly Thr Ser Leu Ser Glu Lys Thr Val 
            100                 105                 110         


Leu Leu Leu Val Thr Pro Phe Leu Ala Ala Ala Trp Ser Leu His Pro 
        115                 120                 125             


<210>  2391
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  2391

Met Gly Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Ala Val Phe Cys His Ser Gly His Ser Leu Gln Cys Tyr Asn Cys Pro 
            20                  25                  30          


Asn Pro Thr Ala Asp Cys Lys Thr Ala Val Asn Cys Ser Ser Asp Phe 
        35                  40                  45              


Asp Ala Cys Leu Ile Thr Lys Ala Gly Leu Gln Val Tyr Asn Lys Cys 
    50                  55                  60                  


Trp Lys Phe Glu His Cys Asn Phe Asn Asp Val Thr Thr Arg Leu Arg 
65                  70                  75                  80  


Glu Asn Glu Leu Thr Tyr Tyr Cys Cys Lys Lys Asp Leu Cys Asn Phe 
                85                  90                  95      


Asn Glu Gln Leu Glu Asn Gly Gly Thr Ser Leu Ser Glu Lys Thr Val 
            100                 105                 110         


Leu Leu Leu Val Thr Pro Phe Leu Ala Ala Ala Trp Ser Leu His Pro 
        115                 120                 125             


<210>  2392
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  2392

Met Gly Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Ala Val Phe Cys His Ser Gly His Ser Leu Gln Cys Tyr Asn Cys Pro 
            20                  25                  30          


Asn Pro Thr Ala Asp Cys Lys Thr Ala Val Asn Cys Ser Ser Asp Phe 
        35                  40                  45              


Asp Ala Cys Leu Ile Thr Lys Ala Gly Leu Gln Val Tyr Asn Lys Cys 
    50                  55                  60                  


Trp Lys Phe Glu His Cys Asn Phe Asn Asp Val Thr Thr Arg Leu Arg 
65                  70                  75                  80  


Glu Asn Glu Leu Thr Tyr Tyr Cys Cys Lys Lys Asp Leu Cys Asn Phe 
                85                  90                  95      


Asn Glu Gln Leu Glu Asn Gly Gly Thr Ser Leu Ser Glu Lys Thr Val 
            100                 105                 110         


Leu Leu Leu Val Thr Pro Phe Leu Ala Ala Ala Trp Ser Leu His Pro 
        115                 120                 125             


<210>  2393
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  2393

Met Gly Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Ala Val Phe Cys His Ser Gly His Ser Leu Gln Cys Tyr Asn Cys Pro 
            20                  25                  30          


Asn Pro Thr Ala Asp Cys Lys Thr Ala Val Asn Cys Ser Ser Asp Phe 
        35                  40                  45              


Asp Ala Cys Leu Ile Thr Lys Ala Gly Leu Gln Val Tyr Asn Lys Cys 
    50                  55                  60                  


Trp Lys Phe Glu His Cys Asn Phe Asn Asp Val Thr Thr Arg Leu Arg 
65                  70                  75                  80  


Glu Asn Glu Leu Thr Tyr Tyr Cys Cys Lys Lys Asp Leu Cys Asn Phe 
                85                  90                  95      


Asn Glu Gln Leu Glu Asn Gly Gly Thr Ser Leu Ser Glu Lys Thr Val 
            100                 105                 110         


Leu Leu Leu Val Thr Pro Phe Leu Ala Ala Ala Trp Ser Leu His Pro 
        115                 120                 125             


<210>  2394
<211>  347
<212>  PRT
<213>  Homo Sapiens

<400>  2394

Met Ala Leu Leu Phe Ser Leu Ile Leu Ala Ile Cys Thr Arg Pro Gly 
1               5                   10                  15      


Phe Leu Ala Ser Pro Ser Gly Val Arg Leu Val Gly Gly Leu His Arg 
            20                  25                  30          


Cys Glu Gly Arg Val Glu Val Glu Gln Lys Gly Gln Trp Gly Thr Val 
        35                  40                  45              


Cys Asp Asp Gly Trp Asp Ile Lys Asp Val Ala Val Leu Cys Arg Glu 
    50                  55                  60                  


Leu Gly Cys Gly Ala Ala Ser Gly Thr Pro Ser Gly Ile Leu Tyr Glu 
65                  70                  75                  80  


Pro Pro Ala Glu Lys Glu Gln Lys Val Leu Ile Gln Ser Val Ser Cys 
                85                  90                  95      


Thr Gly Thr Glu Asp Thr Leu Ala Gln Cys Glu Gln Glu Glu Val Tyr 
            100                 105                 110         


Asp Cys Ser His Asp Glu Asp Ala Gly Ala Ser Cys Glu Asn Pro Glu 
        115                 120                 125             


Ser Ser Phe Ser Pro Val Pro Glu Gly Val Arg Leu Ala Asp Gly Pro 
    130                 135                 140                 


Gly His Cys Lys Gly Arg Val Glu Val Lys His Gln Asn Gln Trp Tyr 
145                 150                 155                 160 


Thr Val Cys Gln Thr Gly Trp Ser Leu Arg Ala Ala Lys Val Val Cys 
                165                 170                 175     


Arg Gln Leu Gly Cys Gly Arg Ala Val Leu Thr Gln Lys Arg Cys Asn 
            180                 185                 190         


Lys His Ala Tyr Gly Arg Lys Pro Ile Trp Leu Ser Gln Met Ser Cys 
        195                 200                 205             


Ser Gly Arg Glu Ala Thr Leu Gln Asp Cys Pro Ser Gly Pro Trp Gly 
    210                 215                 220                 


Lys Asn Thr Cys Asn His Asp Glu Asp Thr Trp Val Glu Cys Glu Asp 
225                 230                 235                 240 


Pro Phe Asp Leu Arg Leu Val Gly Gly Asp Asn Leu Cys Ser Gly Arg 
                245                 250                 255     


Leu Glu Val Leu His Lys Gly Val Trp Gly Ser Val Cys Asp Asp Asn 
            260                 265                 270         


Trp Gly Glu Lys Glu Asp Gln Val Val Cys Lys Gln Leu Gly Cys Gly 
        275                 280                 285             


Lys Ser Leu Ser Pro Ser Phe Arg Asp Arg Lys Cys Tyr Gly Pro Gly 
    290                 295                 300                 


Val Gly Arg Ile Trp Leu Asp Asn Val Arg Cys Ser Gly Glu Glu Gln 
305                 310                 315                 320 


Ser Leu Glu Gln Cys Gln His Arg Phe Trp Gly Phe His Asp Cys Thr 
                325                 330                 335     


His Gln Glu Asp Val Ala Val Ile Cys Ser Gly 
            340                 345         


<210>  2395
<211>  38
<212>  PRT
<213>  Homo Sapiens

<400>  2395

Met Trp Leu Phe Phe Gly Ile Thr Gly Leu Leu Thr Ala Ala Leu Ser 
1               5                   10                  15      


Gly Cys Thr Val Ala Lys Trp Ile Gln Leu Leu Gly Glu Ile Cys Cys 
            20                  25                  30          


Phe Ala Gly Met Gly Phe 
        35              


<210>  2396
<211>  468
<212>  PRT
<213>  Homo Sapiens

<400>  2396

Met Trp Leu Phe Phe Gly Ile Thr Gly Leu Leu Thr Ala Ala Leu Ser 
1               5                   10                  15      


Gly His Pro Ser Pro Ala Pro Pro Asp Gln Leu Asn Thr Ser Ser Ala 
            20                  25                  30          


Glu Ser Glu Leu Trp Glu Pro Gly Glu Arg Leu Pro Val Arg Leu Thr 
        35                  40                  45              


Asn Gly Ser Ser Ser Cys Ser Gly Thr Val Glu Val Arg Leu Glu Ala 
    50                  55                  60                  


Ser Trp Glu Pro Ala Cys Gly Ala Leu Trp Asp Ser Arg Ala Ala Glu 
65                  70                  75                  80  


Ala Val Cys Arg Ala Leu Gly Cys Gly Gly Ala Glu Ala Ala Ser Gln 
                85                  90                  95      


Leu Ala Pro Pro Thr Pro Glu Leu Pro Pro Pro Pro Ala Ala Gly Asn 
            100                 105                 110         


Thr Ser Val Ala Ala Asn Ala Thr Leu Ala Gly Ala Pro Ala Leu Leu 
        115                 120                 125             


Cys Ser Gly Ala Glu Trp Arg Leu Cys Glu Val Val Glu His Ala Cys 
    130                 135                 140                 


Arg Ser Asp Gly Arg Arg Ala Arg Val Thr Cys Ala Glu Asn Arg Ala 
145                 150                 155                 160 


Leu Arg Leu Val Asp Gly Gly Gly Ala Cys Ala Gly Arg Val Glu Met 
                165                 170                 175     


Leu Glu His Gly Glu Trp Gly Ser Val Cys Asp Asp Thr Trp Asp Leu 
            180                 185                 190         


Glu Asp Ala His Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Val 
        195                 200                 205             


Gln Ala Leu Pro Gly Leu His Phe Thr Pro Gly Arg Gly Pro Ile His 
    210                 215                 220                 


Arg Asp Gln Val Asn Cys Ser Gly Ala Glu Ala Tyr Leu Trp Asp Cys 
225                 230                 235                 240 


Pro Gly Leu Pro Gly Gln His Tyr Cys Gly His Lys Glu Asp Ala Gly 
                245                 250                 255     


Ala Val Cys Ser Glu His Gln Ser Trp Arg Leu Thr Gly Gly Ala Asp 
            260                 265                 270         


Arg Cys Glu Gly Gln Val Glu Val His Phe Arg Gly Val Trp Asn Thr 
        275                 280                 285             


Val Cys Asp Ser Glu Trp Tyr Pro Ser Glu Ala Lys Val Leu Cys Gln 
    290                 295                 300                 


Ser Leu Gly Cys Gly Thr Ala Val Glu Arg Pro Lys Gly Leu Pro His 
305                 310                 315                 320 


Ser Leu Ser Gly Arg Met Tyr Tyr Ser Cys Asn Gly Glu Glu Leu Thr 
                325                 330                 335     


Leu Ser Asn Cys Ser Trp Arg Phe Asn Asn Ser Asn Leu Cys Ser Gln 
            340                 345                 350         


Ser Leu Ala Ala Arg Val Leu Cys Ser Ala Ser Arg Ser Leu His Asn 
        355                 360                 365             


Leu Ser Thr Pro Glu Val Pro Ala Ser Val Gln Thr Val Thr Ile Glu 
    370                 375                 380                 


Ser Ser Val Thr Val Lys Ile Glu Asn Lys Glu Ser Arg Glu Leu Met 
385                 390                 395                 400 


Leu Leu Ile Pro Ser Ile Val Leu Gly Ile Leu Leu Leu Gly Ser Leu 
                405                 410                 415     


Ile Phe Ile Ala Phe Ile Leu Leu Arg Ile Lys Gly Lys Tyr Ala Leu 
            420                 425                 430         


Pro Val Met Val Asn His Gln His Leu Pro Thr Thr Ile Pro Ala Gly 
        435                 440                 445             


Ser Asn Ser Tyr Gln Pro Val Pro Ile Thr Ile Pro Lys Glu Gly Pro 
    450                 455                 460                 


Gly Pro Ala Pro 
465             


<210>  2397
<211>  668
<212>  PRT
<213>  Homo Sapiens

<400>  2397

Met Trp Leu Phe Phe Gly Ile Thr Gly Leu Leu Thr Ala Ala Leu Ser 
1               5                   10                  15      


Gly His Pro Ser Pro Ala Pro Pro Asp Gln Leu Asn Thr Ser Ser Ala 
            20                  25                  30          


Glu Ser Glu Leu Trp Glu Pro Gly Glu Arg Leu Pro Val Arg Leu Thr 
        35                  40                  45              


Asn Gly Ser Ser Ser Cys Ser Gly Thr Val Glu Val Arg Leu Glu Ala 
    50                  55                  60                  


Ser Trp Glu Pro Ala Cys Gly Ala Leu Trp Asp Ser Arg Ala Ala Glu 
65                  70                  75                  80  


Ala Val Cys Arg Ala Leu Gly Cys Gly Gly Ala Glu Ala Ala Ser Gln 
                85                  90                  95      


Leu Ala Pro Pro Thr Pro Glu Leu Pro Pro Pro Pro Ala Ala Gly Asn 
            100                 105                 110         


Thr Ser Val Ala Ala Asn Ala Thr Leu Ala Gly Ala Pro Ala Leu Leu 
        115                 120                 125             


Cys Ser Gly Ala Glu Trp Arg Leu Cys Glu Val Val Glu His Ala Cys 
    130                 135                 140                 


Arg Ser Asp Gly Arg Arg Ala Arg Val Thr Cys Ala Glu Asn Arg Ala 
145                 150                 155                 160 


Leu Arg Leu Val Asp Gly Gly Gly Ala Cys Ala Gly Arg Val Glu Met 
                165                 170                 175     


Leu Glu His Gly Glu Trp Gly Ser Val Cys Asp Asp Thr Trp Asp Leu 
            180                 185                 190         


Glu Asp Ala His Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Val 
        195                 200                 205             


Gln Ala Leu Pro Gly Leu His Phe Thr Pro Gly Arg Gly Pro Ile His 
    210                 215                 220                 


Arg Asp Gln Val Asn Cys Ser Gly Ala Glu Ala Tyr Leu Trp Asp Cys 
225                 230                 235                 240 


Pro Gly Leu Pro Gly Gln His Tyr Cys Gly His Lys Glu Asp Ala Gly 
                245                 250                 255     


Ala Val Cys Ser Glu His Gln Ser Trp Arg Leu Thr Gly Gly Ala Asp 
            260                 265                 270         


Arg Cys Glu Gly Gln Val Glu Val His Phe Arg Gly Val Trp Asn Thr 
        275                 280                 285             


Val Cys Asp Ser Glu Trp Tyr Pro Ser Glu Ala Lys Val Leu Cys Gln 
    290                 295                 300                 


Ser Leu Gly Cys Gly Thr Ala Val Glu Arg Pro Lys Gly Leu Pro His 
305                 310                 315                 320 


Ser Leu Ser Gly Arg Met Tyr Tyr Ser Cys Asn Gly Glu Glu Leu Thr 
                325                 330                 335     


Leu Ser Asn Cys Ser Trp Arg Phe Asn Asn Ser Asn Leu Cys Ser Gln 
            340                 345                 350         


Ser Leu Ala Ala Arg Val Leu Cys Ser Ala Ser Arg Ser Leu His Asn 
        355                 360                 365             


Leu Ser Thr Pro Glu Val Pro Ala Ser Val Gln Thr Val Thr Ile Glu 
    370                 375                 380                 


Ser Ser Val Thr Val Lys Ile Glu Asn Lys Glu Ser Arg Glu Leu Met 
385                 390                 395                 400 


Leu Leu Ile Pro Ser Ile Val Leu Gly Ile Leu Leu Leu Gly Ser Leu 
                405                 410                 415     


Ile Phe Ile Ala Phe Ile Leu Leu Arg Ile Lys Gly Lys Tyr Ala Leu 
            420                 425                 430         


Pro Val Met Val Asn His Gln His Leu Pro Thr Thr Ile Pro Ala Gly 
        435                 440                 445             


Ser Asn Ser Tyr Gln Pro Val Pro Ile Thr Ile Pro Lys Glu Val Phe 
    450                 455                 460                 


Met Leu Pro Ile Gln Val Gln Ala Pro Pro Pro Glu Asp Ser Asp Ser 
465                 470                 475                 480 


Gly Ser Asp Ser Asp Tyr Glu His Tyr Asp Phe Ser Ala Gln Pro Pro 
                485                 490                 495     


Val Ala Leu Thr Thr Phe Tyr Asn Ser Gln Arg His Arg Val Thr Asp 
            500                 505                 510         


Glu Glu Val Gln Gln Ser Arg Phe Gln Met Pro Pro Leu Glu Glu Gly 
        515                 520                 525             


Leu Glu Glu Leu His Ala Ser His Ile Pro Thr Ala Asn Pro Gly His 
    530                 535                 540                 


Cys Ile Thr Asp Pro Pro Ser Leu Gly Pro Gln Tyr His Pro Arg Ser 
545                 550                 555                 560 


Asn Ser Glu Ser Ser Thr Ser Ser Gly Glu Asp Tyr Cys Asn Ser Pro 
                565                 570                 575     


Lys Ser Lys Leu Pro Pro Trp Asn Pro Gln Val Phe Ser Ser Glu Arg 
            580                 585                 590         


Ser Ser Phe Leu Glu Gln Pro Pro Asn Leu Glu Leu Ala Gly Thr Gln 
        595                 600                 605             


Pro Ala Phe Ser Ala Gly Pro Pro Ala Asp Asp Ser Ser Ser Thr Ser 
    610                 615                 620                 


Ser Gly Glu Trp Tyr Gln Asn Phe Gln Pro Pro Pro Gln Pro Pro Ser 
625                 630                 635                 640 


Glu Glu Gln Phe Gly Cys Pro Gly Ser Pro Ser Pro Gln Pro Asp Ser 
                645                 650                 655     


Thr Asp Asn Asp Asp Tyr Asp Asp Ile Ser Ala Ala 
            660                 665             


<210>  2398
<211>  601
<212>  PRT
<213>  Homo Sapiens

<400>  2398

Met Trp Leu Phe Phe Gly Ile Thr Gly Leu Leu Thr Ala Ala Leu Ser 
1               5                   10                  15      


Gly His Pro Ser Pro Ala Pro Pro Asp Gln Leu Asn Thr Ser Ser Ala 
            20                  25                  30          


Glu Ser Glu Leu Trp Glu Pro Gly Glu Arg Leu Pro Val Arg Leu Thr 
        35                  40                  45              


Asn Gly Ser Ser Ser Cys Ser Gly Thr Val Glu Val Arg Leu Glu Ala 
    50                  55                  60                  


Ser Trp Glu Pro Ala Cys Gly Ala Leu Trp Asp Ser Arg Ala Ala Glu 
65                  70                  75                  80  


Ala Val Cys Arg Ala Leu Gly Cys Gly Gly Ala Glu Ala Ala Ser Gln 
                85                  90                  95      


Leu Ala Pro Pro Thr Pro Glu Leu Pro Pro Pro Pro Ala Ala Gly Asn 
            100                 105                 110         


Thr Ser Val Ala Ala Asn Ala Thr Leu Ala Gly Ala Pro Ala Leu Leu 
        115                 120                 125             


Cys Ser Gly Ala Glu Trp Arg Leu Cys Glu Val Val Glu His Ala Cys 
    130                 135                 140                 


Arg Ser Asp Gly Arg Arg Ala Arg Val Thr Cys Ala Glu Asn Arg Ala 
145                 150                 155                 160 


Leu Arg Leu Val Asp Gly Gly Gly Ala Cys Ala Gly Arg Val Glu Met 
                165                 170                 175     


Leu Glu His Gly Glu Trp Gly Ser Val Cys Asp Asp Thr Trp Asp Leu 
            180                 185                 190         


Glu Asp Ala His Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Val 
        195                 200                 205             


Gln Ala Leu Pro Gly Leu His Phe Thr Pro Gly Arg Gly Pro Ile His 
    210                 215                 220                 


Arg Asp Gln Val Asn Cys Ser Gly Ala Glu Ala Tyr Leu Trp Asp Cys 
225                 230                 235                 240 


Pro Gly Leu Pro Gly Gln His Tyr Cys Gly His Lys Glu Asp Ala Gly 
                245                 250                 255     


Ala Val Cys Ser Glu His Gln Ser Trp Arg Leu Thr Gly Gly Ala Asp 
            260                 265                 270         


Arg Cys Glu Gly Gln Val Glu Val His Phe Arg Gly Val Trp Asn Thr 
        275                 280                 285             


Val Cys Asp Ser Glu Trp Tyr Pro Ser Glu Ala Lys Val Leu Cys Gln 
    290                 295                 300                 


Ser Leu Gly Cys Gly Thr Ala Val Glu Arg Pro Lys Gly Leu Pro His 
305                 310                 315                 320 


Ser Leu Ser Gly Arg Met Tyr Tyr Ser Cys Asn Gly Glu Glu Leu Thr 
                325                 330                 335     


Leu Ser Asn Cys Ser Trp Arg Phe Asn Asn Ser Asn Leu Cys Ser Gln 
            340                 345                 350         


Ser Leu Ala Ala Arg Val Leu Cys Ser Ala Ser Arg Ser Leu His Asn 
        355                 360                 365             


Leu Ser Thr Pro Glu Val Pro Ala Ser Val Gln Thr Val Thr Ile Glu 
    370                 375                 380                 


Ser Ser Val Thr Val Lys Ile Glu Asn Lys Glu Ser Arg Glu Leu Met 
385                 390                 395                 400 


Leu Leu Ile Pro Ser Ile Val Leu Gly Ile Leu Leu Leu Gly Ser Leu 
                405                 410                 415     


Ile Phe Ile Ala Phe Ile Leu Leu Arg Ile Lys Gly Lys Tyr Val Phe 
            420                 425                 430         


Met Leu Pro Ile Gln Val Gln Ala Pro Pro Pro Glu Asp Ser Asp Ser 
        435                 440                 445             


Gly Ser Asp Ser Asp Tyr Glu His Tyr Asp Phe Ser Ala Gln Pro Pro 
    450                 455                 460                 


Val Ala Leu Thr Thr Phe Tyr Asn Ser Gln Arg His Arg Val Thr Asp 
465                 470                 475                 480 


Glu Glu Val Gln Gln Ser Arg Phe Gln Met Pro Pro Leu Glu Glu Gly 
                485                 490                 495     


Leu Glu Glu Leu His Ala Ser His Ile Pro Thr Ala Asn Pro Gly His 
            500                 505                 510         


Cys Ile Thr Asp Pro Pro Ser Leu Gly Pro Gln Tyr His Pro Arg Ser 
        515                 520                 525             


Asn Ser Glu Ser Ser Thr Ser Ser Gly Glu Asp Tyr Cys Asn Ser Pro 
    530                 535                 540                 


Lys Ser Lys Leu Pro Pro Trp Asn Pro Gln Val Phe Ser Ser Glu Arg 
545                 550                 555                 560 


Ser Ser Phe Leu Glu Gln Pro Pro Asn Leu Glu Leu Ala Gly Thr Gln 
                565                 570                 575     


Pro Ala Phe Ser Gly Ser Pro Ser Pro Gln Pro Asp Ser Thr Asp Asn 
            580                 585                 590         


Asp Asp Tyr Asp Asp Ile Ser Ala Ala 
        595                 600     


<210>  2399
<211>  592
<212>  PRT
<213>  Homo Sapiens

<400>  2399

Met Trp Leu Phe Phe Gly Ile Thr Gly Leu Leu Thr Ala Ala Leu Ser 
1               5                   10                  15      


Gly His Pro Ser Pro Ala Pro Pro Asp Gln Leu Asn Thr Ser Ser Ala 
            20                  25                  30          


Glu Ser Glu Leu Trp Glu Pro Gly Glu Arg Leu Pro Val Arg Leu Thr 
        35                  40                  45              


Asn Gly Ser Ser Ser Cys Ser Gly Thr Val Glu Val Arg Leu Glu Ala 
    50                  55                  60                  


Ser Trp Glu Pro Ala Cys Gly Ala Leu Trp Asp Ser Arg Ala Ala Glu 
65                  70                  75                  80  


Ala Val Cys Arg Ala Leu Gly Cys Gly Gly Ala Glu Ala Ala Ser Gln 
                85                  90                  95      


Leu Ala Pro Pro Thr Pro Glu Leu Pro Pro Pro Pro Ala Ala Gly Asn 
            100                 105                 110         


Thr Ser Val Ala Ala Asn Ala Thr Leu Ala Gly Ala Pro Ala Leu Leu 
        115                 120                 125             


Cys Ser Gly Ala Glu Trp Arg Leu Cys Glu Val Val Glu His Ala Cys 
    130                 135                 140                 


Arg Ser Asp Gly Arg Arg Ala Arg Val Thr Cys Ala Glu Asn Arg Ala 
145                 150                 155                 160 


Leu Arg Leu Val Asp Gly Gly Gly Ala Cys Ala Gly Arg Val Glu Met 
                165                 170                 175     


Leu Glu His Gly Glu Trp Gly Ser Val Cys Asp Asp Thr Trp Asp Leu 
            180                 185                 190         


Glu Asp Ala His Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Val 
        195                 200                 205             


Gln Ala Leu Pro Gly Leu His Phe Thr Pro Gly Arg Gly Pro Ile His 
    210                 215                 220                 


Arg Asp Gln Val Asn Cys Ser Gly Ala Glu Ala Tyr Leu Trp Asp Cys 
225                 230                 235                 240 


Pro Gly Leu Pro Gly Gln His Tyr Cys Gly His Lys Glu Asp Ala Gly 
                245                 250                 255     


Ala Val Cys Ser Glu His Gln Ser Trp Arg Leu Thr Gly Gly Ala Asp 
            260                 265                 270         


Arg Cys Glu Gly Gln Val Glu Val His Phe Arg Gly Val Trp Asn Thr 
        275                 280                 285             


Val Cys Asp Ser Glu Trp Tyr Pro Ser Glu Ala Lys Val Leu Cys Gln 
    290                 295                 300                 


Ser Leu Gly Cys Gly Thr Ala Val Glu Arg Pro Lys Gly Leu Pro His 
305                 310                 315                 320 


Ser Leu Ser Gly Arg Met Tyr Tyr Ser Cys Asn Gly Glu Glu Leu Thr 
                325                 330                 335     


Leu Ser Asn Cys Ser Trp Arg Phe Asn Asn Ser Asn Leu Cys Ser Gln 
            340                 345                 350         


Ser Leu Ala Ala Arg Val Leu Cys Ser Ala Ser Arg Ser Leu His Asn 
        355                 360                 365             


Leu Ser Thr Pro Glu Val Pro Ala Ser Val Gln Thr Val Thr Ile Glu 
    370                 375                 380                 


Ser Ser Val Thr Val Lys Ile Glu Asn Lys Glu Ser Arg Glu Leu Met 
385                 390                 395                 400 


Leu Leu Ile Pro Ser Ile Val Leu Gly Ile Leu Leu Leu Gly Ser Leu 
                405                 410                 415     


Ile Phe Ile Ala Phe Ile Leu Leu Arg Ile Lys Gly Lys Tyr Ala Leu 
            420                 425                 430         


Pro Val Met Val Asn His Gln His Leu Pro Thr Thr Ile Pro Ala Gly 
        435                 440                 445             


Ser Asn Ser Tyr Gln Pro Val Pro Ile Thr Ile Pro Lys Glu Asp Ser 
    450                 455                 460                 


Gln Arg His Arg Val Thr Asp Glu Glu Val Gln Gln Ser Arg Phe Gln 
465                 470                 475                 480 


Met Pro Pro Leu Glu Glu Gly Leu Glu Glu Leu His Ala Ser His Ile 
                485                 490                 495     


Pro Thr Ala Asn Pro Gly His Cys Ile Thr Asp Pro Pro Ser Leu Gly 
            500                 505                 510         


Pro Gln Tyr His Pro Arg Ser Asn Ser Glu Ser Ser Thr Ser Ser Gly 
        515                 520                 525             


Glu Asp Tyr Cys Asn Ser Pro Lys Ser Lys Leu Pro Pro Trp Asn Pro 
    530                 535                 540                 


Gln Val Phe Ser Ser Glu Arg Ser Ser Phe Leu Glu Gln Pro Pro Asn 
545                 550                 555                 560 


Leu Glu Leu Ala Gly Thr Gln Pro Ala Phe Ser Gly Ser Pro Ser Pro 
                565                 570                 575     


Gln Pro Asp Ser Thr Asp Asn Asp Asp Tyr Asp Asp Ile Ser Ala Ala 
            580                 585                 590         


<210>  2400
<211>  422
<212>  PRT
<213>  Homo Sapiens

<400>  2400

Met Trp Leu Phe Phe Gly Ile Thr Gly Leu Leu Thr Ala Ala Leu Ser 
1               5                   10                  15      


Gly His Pro Ser Pro Ala Pro Pro Asp Gln Leu Asn Thr Ser Ser Ala 
            20                  25                  30          


Glu Ser Glu Leu Trp Glu Pro Gly Glu Arg Leu Pro Val Arg Leu Thr 
        35                  40                  45              


Asn Gly Ser Ser Ser Cys Ser Gly Thr Val Glu Val Arg Leu Glu Ala 
    50                  55                  60                  


Ser Trp Glu Pro Ala Cys Gly Ala Leu Trp Asp Ser Arg Ala Ala Glu 
65                  70                  75                  80  


Ala Val Cys Arg Ala Leu Gly Cys Gly Gly Ala Glu Ala Ala Ser Gln 
                85                  90                  95      


Leu Ala Pro Pro Thr Pro Glu Leu Pro Pro Pro Pro Ala Ala Gly Asn 
            100                 105                 110         


Thr Ser Val Ala Ala Asn Ala Thr Leu Ala Gly Ala Pro Ala Leu Leu 
        115                 120                 125             


Cys Ser Gly Ala Glu Trp Arg Leu Cys Glu Val Val Glu His Ala Cys 
    130                 135                 140                 


Arg Ser Asp Gly Arg Arg Ala Arg Val Thr Cys Ala Glu Asn Arg Ala 
145                 150                 155                 160 


Leu Arg Leu Val Asp Gly Gly Gly Ala Cys Ala Gly Arg Val Glu Met 
                165                 170                 175     


Leu Glu His Gly Glu Trp Gly Ser Val Cys Asp Asp Thr Trp Asp Leu 
            180                 185                 190         


Glu Asp Ala His Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Val 
        195                 200                 205             


Gln Ala Leu Pro Gly Leu His Phe Thr Pro Gly Arg Gly Pro Ile His 
    210                 215                 220                 


Arg Asp Gln Val Asn Cys Ser Gly Ala Glu Ala Tyr Leu Trp Asp Cys 
225                 230                 235                 240 


Pro Gly Leu Pro Gly Gln His Tyr Cys Gly His Lys Glu Asp Ala Gly 
                245                 250                 255     


Ala Val Cys Ser Ala Ser Arg Ser Leu His Asn Leu Ser Thr Pro Glu 
            260                 265                 270         


Val Pro Ala Ser Val Gln Thr Val Thr Ile Glu Ser Ser Val Thr Val 
        275                 280                 285             


Lys Ile Glu Asn Lys Glu Ser Arg Glu Leu Met Leu Leu Ile Pro Ser 
    290                 295                 300                 


Ile Val Leu Gly Ile Leu Leu Leu Gly Ser Leu Ile Phe Ile Ala Phe 
305                 310                 315                 320 


Ile Leu Leu Arg Ile Lys Gly Lys Tyr Val Phe Met Leu Pro Ile Gln 
                325                 330                 335     


Val Gln Ala Pro Pro Pro Glu Asp Ser Asp Ser Gly Ser Asp Ser Asp 
            340                 345                 350         


Tyr Glu His Tyr Asp Phe Ser Ala Gln Pro Pro Val Ala Leu Thr Thr 
        355                 360                 365             


Phe Tyr Asn Ser Gln Arg His Arg Val Thr Asp Glu Glu Val Gln Gln 
    370                 375                 380                 


Ser Arg Phe Gln Met Pro Pro Leu Glu Glu Gly Leu Glu Glu Leu His 
385                 390                 395                 400 


Ala Ser His Ile Pro Thr Ala Asn Pro Gly His Cys Ile Thr Asp Pro 
                405                 410                 415     


Pro Ser Leu Gly Pro Gln 
            420         


<210>  2401
<211>  278
<212>  PRT
<213>  Homo Sapiens

<400>  2401

Met Trp Leu Phe Phe Gly Ile Thr Gly Leu Leu Thr Ala Ala Leu Ser 
1               5                   10                  15      


Gly His Pro Ser Pro Ala Pro Pro Asp Gln Leu Asn Thr Ser Ser Ala 
            20                  25                  30          


Glu Ser Glu Leu Trp Glu Pro Gly Glu Arg Leu Pro Val Arg Leu Thr 
        35                  40                  45              


Asn Gly Ser Ser Ser Cys Ser Gly Thr Val Glu Val Arg Leu Glu Ala 
    50                  55                  60                  


Ser Trp Glu Pro Ala Cys Gly Ala Leu Trp Asp Ser Arg Ala Ala Glu 
65                  70                  75                  80  


Ala Val Cys Arg Ala Leu Gly Cys Gly Gly Ala Glu Ala Ala Ser Gln 
                85                  90                  95      


Leu Ala Pro Pro Thr Pro Glu Leu Pro Pro Pro Pro Ala Ala Gly Asn 
            100                 105                 110         


Thr Ser Val Ala Ala Asn Ala Thr Leu Ala Gly Ala Pro Ala Leu Leu 
        115                 120                 125             


Cys Ser Gly Ala Glu Trp Arg Leu Cys Glu Val Val Glu His Ala Cys 
    130                 135                 140                 


Arg Ser Asp Gly Arg Arg Ala Arg Val Thr Cys Ala Glu Asn Arg Ala 
145                 150                 155                 160 


Leu Arg Leu Val Asp Gly Gly Gly Ala Cys Ala Gly Arg Val Glu Met 
                165                 170                 175     


Leu Glu His Gly Glu Trp Gly Ser Val Cys Asp Asp Thr Trp Asp Leu 
            180                 185                 190         


Glu Asp Ala His Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Val 
        195                 200                 205             


Gln Ala Leu Pro Gly Leu His Phe Thr Pro Gly Arg Gly Pro Ile His 
    210                 215                 220                 


Arg Asp Gln Val Asn Cys Ser Gly Ala Glu Ala Tyr Leu Trp Asp Cys 
225                 230                 235                 240 


Pro Gly Leu Pro Gly Gln His Tyr Cys Gly His Lys Glu Asp Ala Gly 
                245                 250                 255     


Ala Val Cys Ser Glu Ser Ser Val Thr Val Lys Ile Glu Asn Lys Glu 
            260                 265                 270         


Ser Arg Glu Leu Met Leu 
        275             


<210>  2402
<211>  186
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2402

Xaa Asn Arg Ala Leu Arg Leu Val Asp Gly Gly Gly Ala Cys Ala Gly 
1               5                   10                  15      


Arg Val Glu Met Leu Glu His Gly Glu Trp Gly Ser Val Cys Asp Asp 
            20                  25                  30          


Thr Trp Asp Leu Glu Asp Ala His Val Val Cys Arg Gln Leu Gly Cys 
        35                  40                  45              


Gly Trp Ala Val Gln Ala Leu Pro Gly Leu His Phe Thr Pro Gly Arg 
    50                  55                  60                  


Gly Pro Ile His Arg Asp Gln Val Asn Cys Ser Gly Ala Glu Ala Tyr 
65                  70                  75                  80  


Leu Trp Asp Cys Pro Gly Leu Pro Gly Gln His Tyr Cys Gly His Lys 
                85                  90                  95      


Glu Asp Ala Gly Ala Val Cys Ser Ala Ser Arg Ser Leu His Asn Leu 
            100                 105                 110         


Ser Thr Pro Glu Val Pro Ala Ser Val Gln Thr Val Thr Ile Glu Ser 
        115                 120                 125             


Ser Val Thr Val Lys Ile Glu Asn Lys Glu Ser Arg Glu Leu Met Leu 
    130                 135                 140                 


Leu Ile Pro Ser Ile Val Leu Gly Ile Leu Leu Leu Gly Ser Leu Ile 
145                 150                 155                 160 


Phe Ile Ala Phe Ile Leu Leu Arg Ile Lys Gly Lys Tyr Ala Leu Pro 
                165                 170                 175     


Val Met Val Asn His Gln His Leu Pro Thr 
            180                 185     


<210>  2403
<211>  354
<212>  PRT
<213>  Homo Sapiens

<400>  2403

Met Arg Leu Ala Val Leu Phe Ser Gly Ala Leu Leu Gly Leu Leu Ala 
1               5                   10                  15      


Ala Gln Gly Thr Gly Asn Asp Cys Pro His Lys Lys Ser Ala Thr Leu 
            20                  25                  30          


Leu Pro Ser Phe Thr Val Thr Pro Thr Val Thr Glu Ser Thr Gly Thr 
        35                  40                  45              


Thr Ser His Arg Thr Thr Lys Ser His Lys Thr Thr Thr His Arg Thr 
    50                  55                  60                  


Thr Thr Thr Gly Thr Thr Ser His Gly Pro Thr Thr Ala Thr His Asn 
65                  70                  75                  80  


Pro Thr Thr Thr Ser His Gly Asn Val Thr Val His Pro Thr Ser Asn 
                85                  90                  95      


Ser Thr Ala Thr Ser Gln Gly Pro Ser Thr Ala Thr His Ser Pro Ala 
            100                 105                 110         


Thr Thr Ser His Gly Asn Ala Thr Val His Pro Thr Ser Asn Ser Thr 
        115                 120                 125             


Ala Thr Ser Pro Gly Phe Thr Ser Ser Ala His Pro Glu Pro Pro Pro 
    130                 135                 140                 


Pro Ser Pro Ser Pro Ser Pro Thr Ser Lys Glu Thr Ile Gly Asp Tyr 
145                 150                 155                 160 


Thr Trp Thr Asn Gly Ser Gln Pro Cys Val His Leu Gln Ala Gln Ile 
                165                 170                 175     


Gln Ile Arg Val Met Tyr Thr Thr Gln Gly Gly Gly Glu Ala Trp Gly 
            180                 185                 190         


Ile Ser Val Leu Asn Pro Asn Lys Thr Lys Val Gln Gly Ser Cys Glu 
        195                 200                 205             


Gly Ala His Pro His Leu Leu Leu Ser Phe Pro Tyr Gly His Leu Ser 
    210                 215                 220                 


Phe Gly Phe Met Gln Asp Leu Gln Gln Lys Val Val Tyr Leu Ser Tyr 
225                 230                 235                 240 


Met Ala Val Glu Tyr Asn Val Ser Phe Pro His Ala Ala Gln Trp Thr 
                245                 250                 255     


Phe Ser Ala Gln Asn Ala Ser Leu Arg Asp Leu Gln Ala Pro Leu Gly 
            260                 265                 270         


Gln Ser Phe Ser Cys Ser Asn Ser Ser Ile Ile Leu Ser Pro Ala Val 
        275                 280                 285             


His Leu Asp Leu Leu Ser Leu Arg Leu Gln Ala Ala Gln Leu Pro His 
    290                 295                 300                 


Thr Gly Val Phe Gly Gln Ser Phe Ser Cys Pro Ser Asp Arg Ser Ile 
305                 310                 315                 320 


Leu Leu Pro Leu Ile Ile Gly Leu Ile Leu Leu Gly Leu Leu Ala Leu 
                325                 330                 335     


Val Leu Ile Ala Phe Cys Ile Ile Arg Arg Arg Pro Ser Ala Tyr Gln 
            340                 345                 350         


Ala Leu 
        


<210>  2404
<211>  181
<212>  PRT
<213>  Homo Sapiens

<400>  2404

Met Arg Leu Ala Val Leu Phe Ser Gly Ala Leu Leu Gly Leu Leu Ala 
1               5                   10                  15      


Ala Thr Leu Leu Pro Ser Phe Thr Val Thr Pro Thr Val Thr Glu Ser 
            20                  25                  30          


Thr Gly Thr Thr Ser His Arg Thr Thr Lys Ser His Lys Thr Thr Thr 
        35                  40                  45              


His Arg Thr Thr Thr Thr Gly Thr Thr Ser His Gly Pro Thr Thr Ala 
    50                  55                  60                  


Thr His Asn Pro Thr Thr Thr Ser His Gly Asn Val Thr Val His Pro 
65                  70                  75                  80  


Thr Ser Asn Ser Thr Ala Thr Ser Gln Gly Pro Ser Thr Ala Thr His 
                85                  90                  95      


Ser Pro Ala Thr Thr Ser His Gly Asn Ala Thr Val His Pro Thr Ser 
            100                 105                 110         


Asn Ser Thr Ala Thr Ser Pro Gly Phe Thr Ser Ser Ala His Pro Glu 
        115                 120                 125             


Pro Pro Pro Pro Ser Pro Ser Pro Ser Pro Thr Ser Lys Glu Thr Ile 
    130                 135                 140                 


Gly Asp Tyr Thr Trp Thr Asn Gly Ser Gln Pro Cys Val His Leu Gln 
145                 150                 155                 160 


Ala Gln Ile Gln Ile Arg Val Met Tyr Thr Thr Gln Gly Gly Gly Glu 
                165                 170                 175     


Ala Trp Gly Ile Ser 
            180     


<210>  2405
<211>  327
<212>  PRT
<213>  Homo Sapiens

<400>  2405

Met Arg Leu Ala Val Leu Phe Ser Gly Ala Leu Leu Gly Leu Leu Ala 
1               5                   10                  15      


Glu Ser Thr Gly Thr Thr Ser His Arg Thr Thr Lys Ser His Lys Thr 
            20                  25                  30          


Thr Thr His Arg Thr Thr Thr Thr Gly Thr Thr Ser His Gly Pro Thr 
        35                  40                  45              


Thr Ala Thr His Asn Pro Thr Thr Thr Ser His Gly Asn Val Thr Val 
    50                  55                  60                  


His Pro Thr Ser Asn Ser Thr Ala Thr Ser Gln Gly Pro Ser Thr Ala 
65                  70                  75                  80  


Thr His Ser Pro Ala Thr Thr Ser His Gly Asn Ala Thr Val His Pro 
                85                  90                  95      


Thr Ser Asn Ser Thr Ala Thr Ser Pro Gly Phe Thr Ser Ser Ala His 
            100                 105                 110         


Pro Glu Pro Pro Pro Pro Ser Pro Ser Pro Ser Pro Thr Ser Lys Glu 
        115                 120                 125             


Thr Ile Gly Asp Tyr Thr Trp Thr Asn Gly Ser Gln Pro Cys Val His 
    130                 135                 140                 


Leu Gln Ala Gln Ile Gln Ile Arg Val Met Tyr Thr Thr Gln Gly Gly 
145                 150                 155                 160 


Gly Glu Ala Trp Gly Ile Ser Val Leu Asn Pro Asn Lys Thr Lys Val 
                165                 170                 175     


Gln Gly Ser Cys Glu Gly Ala His Pro His Leu Leu Leu Ser Phe Pro 
            180                 185                 190         


Tyr Gly His Leu Ser Phe Gly Phe Met Gln Asp Leu Gln Gln Lys Val 
        195                 200                 205             


Val Tyr Leu Ser Tyr Met Ala Val Glu Tyr Asn Val Ser Phe Pro His 
    210                 215                 220                 


Ala Ala Gln Trp Thr Phe Ser Ala Gln Asn Ala Ser Leu Arg Asp Leu 
225                 230                 235                 240 


Gln Ala Pro Leu Gly Gln Ser Phe Ser Cys Ser Asn Ser Ser Ile Ile 
                245                 250                 255     


Leu Ser Pro Ala Val His Leu Asp Leu Leu Ser Leu Arg Leu Gln Ala 
            260                 265                 270         


Ala Gln Leu Pro His Thr Gly Val Phe Gly Gln Ser Phe Ser Cys Pro 
        275                 280                 285             


Ser Asp Arg Ser Ile Leu Leu Pro Leu Ile Ile Gly Leu Ile Leu Leu 
    290                 295                 300                 


Gly Leu Leu Ala Leu Val Leu Ile Ala Phe Cys Ile Ile Arg Arg Arg 
305                 310                 315                 320 


Pro Ser Ala Tyr Gln Ala Leu 
                325         


<210>  2406
<211>  121
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2406

Xaa Lys Thr Lys Val Gln Gly Ser Cys Glu Gly Ala His Pro His Leu 
1               5                   10                  15      


Leu Leu Ser Phe Pro Tyr Gly His Leu Ser Phe Gly Phe Met Gln Asp 
            20                  25                  30          


Leu Gln Gln Lys Val Val Tyr Leu Ser Tyr Met Ala Val Glu Tyr Asn 
        35                  40                  45              


Val Ser Phe Pro His Ala Ala Gln Trp Thr Phe Ser Ala Gln Asn Ala 
    50                  55                  60                  


Ser Leu Arg Asp Leu Gln Ala Pro Leu Gly Gln Ser Phe Ser Cys Ser 
65                  70                  75                  80  


Asn Ser Ser Ile Ile Leu Ser Pro Ala Val His Leu Asp Leu Leu Ser 
                85                  90                  95      


Leu Arg Leu Gln Ala Ala Gln Leu Pro His Thr Gly Val Phe Gly Gln 
            100                 105                 110         


Ser Lys Thr Tyr Leu Leu Leu Pro Ser 
        115                 120     


<210>  2407
<211>  35
<212>  PRT
<213>  Homo Sapiens

<400>  2407

Met Ala Gly Pro Pro Arg Leu Leu Leu Leu Pro Leu Leu Leu Ala Leu 
1               5                   10                  15      


Ala Arg Gly Leu Pro Gly Ala Leu Ala Ala Gln Ala Gly Ala Cys Val 
            20                  25                  30          


Gly Ser Thr 
        35  


<210>  2408
<211>  240
<212>  PRT
<213>  Homo Sapiens

<400>  2408

Met Ala Gly Pro Pro Arg Leu Leu Leu Leu Pro Leu Leu Leu Ala Leu 
1               5                   10                  15      


Ala Arg Gly Leu Pro Gly Ala Leu Ala Ala Gln Glu Val Gln Gln Ser 
            20                  25                  30          


Pro His Cys Thr Thr Val Pro Val Gly Ala Ser Val Asn Ile Thr Cys 
        35                  40                  45              


Ser Thr Ser Gly Gly Leu Arg Gly Ile Tyr Leu Arg Gln Leu Gly Pro 
    50                  55                  60                  


Gln Pro Gln Asp Ile Ile Tyr Tyr Glu Asp Gly Val Val Pro Thr Thr 
65                  70                  75                  80  


Asp Arg Arg Phe Arg Gly Arg Ile Asp Phe Ser Gly Ser Gln Asp Asn 
                85                  90                  95      


Leu Thr Ile Thr Met His Arg Leu Gln Leu Ser Asp Thr Gly Thr Tyr 
            100                 105                 110         


Thr Cys Gln Ala Ile Thr Glu Val Asn Val Tyr Gly Ser Gly Thr Leu 
        115                 120                 125             


Val Leu Val Thr Glu Glu Gln Ser Gln Gly Trp His Arg Cys Ser Asp 
    130                 135                 140                 


Ala Pro Pro Arg Ala Ser Ala Leu Pro Ala Pro Pro Thr Gly Ser Ala 
145                 150                 155                 160 


Leu Pro Asp Pro Gln Thr Ala Ser Ala Leu Pro Asp Pro Pro Ala Ala 
                165                 170                 175     


Ser Ala Leu Pro Ala Ala Leu Ala Val Ile Ser Phe Leu Leu Gly Leu 
            180                 185                 190         


Gly Leu Gly Val Ala Cys Val Leu Ala Arg Thr Gln Ile Lys Lys Leu 
        195                 200                 205             


Cys Ser Trp Arg Asp Lys Asn Ser Ala Ala Cys Val Val Tyr Glu Asp 
    210                 215                 220                 


Met Ser His Ser Arg Cys Asn Thr Leu Ser Ser Pro Asn Gln Tyr Gln 
225                 230                 235                 240 


<210>  2409
<211>  221
<212>  PRT
<213>  Homo Sapiens

<400>  2409

Met Ala Gly Pro Pro Arg Leu Leu Leu Leu Pro Leu Leu Leu Ala Leu 
1               5                   10                  15      


Ala Arg Gly Leu Pro Gly Ala Leu Ala Ala Gln Glu Val Gln Gln Ser 
            20                  25                  30          


Pro His Cys Thr Thr Val Pro Val Gly Ala Ser Val Asn Ile Thr Cys 
        35                  40                  45              


Ser Thr Ser Gly Gly Leu Arg Gly Ile Tyr Leu Arg Gln Leu Gly Pro 
    50                  55                  60                  


Gln Pro Gln Asp Ile Ile Tyr Tyr Glu Asp Gly Val Val Pro Thr Thr 
65                  70                  75                  80  


Asp Arg Arg Phe Arg Gly Arg Ile Asp Phe Ser Gly Ser Gln Asp Asn 
                85                  90                  95      


Leu Thr Ile Thr Met His Arg Leu Gln Leu Ser Asp Thr Gly Thr Tyr 
            100                 105                 110         


Thr Cys Gln Ala Ile Thr Glu Val Asn Val Tyr Gly Ser Gly Thr Leu 
        115                 120                 125             


Val Leu Val Thr Glu Glu Gln Ser Gln Gly Trp His Arg Cys Ser Asp 
    130                 135                 140                 


Ala Pro Pro Arg Ala Ser Ala Leu Pro Ala Pro Pro Thr Gly Ser Ala 
145                 150                 155                 160 


Leu Pro Asp Pro Gln Thr Ala Ser Ala Leu Pro Asp Pro Pro Ala Ala 
                165                 170                 175     


Ser Ala Leu Pro Ala Ala Leu Ala Val Ile Ser Phe Leu Leu Gly Leu 
            180                 185                 190         


Gly Leu Gly Val Ala Cys Val Leu Ala Arg Thr Gln Val Ser Val Ser 
        195                 200                 205             


Pro Ser Cys His Leu His Pro Lys Asp Cys Ser Leu Ser 
    210                 215                 220     


<210>  2410
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  2410

Met Ala Gly Pro Pro Arg Leu Leu Leu Leu Pro Leu Leu Leu Ala Leu 
1               5                   10                  15      


Ala Arg Gly Leu Pro Gly Ala Leu Ala Ala Gln Gly Arg Thr Phe Ser 
            20                  25                  30          


Val Leu Leu Ala Arg Leu Met Val Thr Ala Gln Val Leu Pro Arg Gly 
        35                  40                  45              


Ala Ala Val Ser Pro Leu His Asp Cys Pro Arg Gly Ser Leu Arg Gln 
    50                  55                  60                  


His His Leu Leu His Gln Arg Gly Pro Ala Trp Asp Leu Pro Glu Ala 
65                  70                  75                  80  


Ala Arg Ala Thr Ala Pro Arg His His Leu Leu Arg Gly Arg Gly Gly 
                85                  90                  95      


Ala His Tyr Gly Gln Thr Val Pro Gly Pro His Arg Leu Leu Arg Val 
            100                 105                 110         


Pro Gly Gln Pro Asp Tyr His His Ala Pro Pro Ala Ala Val Gly His 
        115                 120                 125             


Trp His Leu His Leu Pro Gly His His Gly Gly Gln Cys Leu Arg Leu 
    130                 135                 140                 


Arg His Pro Gly Pro Gly Asp Arg Gly Thr Val Pro Arg Met Ala Gln 
145                 150                 155                 160 


<210>  2411
<211>  140
<212>  PRT
<213>  Homo Sapiens

<400>  2411

Met His Arg Leu Gln Leu Ser Asp Thr Gly Thr Tyr Thr Cys Gln Ala 
1               5                   10                  15      


Ile Thr Glu Val Asn Val Tyr Gly Ser Gly Thr Leu Val Leu Val Thr 
            20                  25                  30          


Glu Glu Gln Ser Gln Gly Trp His Arg Cys Ser Asp Ala Pro Pro Arg 
        35                  40                  45              


Ala Ser Ala Leu Pro Ala Pro Pro Thr Gly Ser Ala Leu Pro Asp Pro 
    50                  55                  60                  


Gln Thr Ala Ser Ala Leu Pro Asp Pro Pro Ala Ala Ser Ala Leu Pro 
65                  70                  75                  80  


Ala Ala Leu Ala Val Ile Ser Phe Leu Leu Gly Leu Gly Leu Gly Val 
                85                  90                  95      


Ala Cys Val Leu Ala Arg Thr Gln Ile Lys Lys Leu Cys Ser Trp Arg 
            100                 105                 110         


Asp Lys Asn Ser Ala Ala Cys Val Val Tyr Glu Asp Met Ser His Ser 
        115                 120                 125             


Arg Cys Asn Thr Leu Ser Ser Pro Asn Gln Tyr Gln 
    130                 135                 140 


<210>  2412
<211>  121
<212>  PRT
<213>  Homo Sapiens

<400>  2412

Met His Arg Leu Gln Leu Ser Asp Thr Gly Thr Tyr Thr Cys Gln Ala 
1               5                   10                  15      


Ile Thr Glu Val Asn Val Tyr Gly Ser Gly Thr Leu Val Leu Val Thr 
            20                  25                  30          


Glu Glu Gln Ser Gln Gly Trp His Arg Cys Ser Asp Ala Pro Pro Arg 
        35                  40                  45              


Ala Ser Ala Leu Pro Ala Pro Pro Thr Gly Ser Ala Leu Pro Asp Pro 
    50                  55                  60                  


Gln Thr Ala Ser Ala Leu Pro Asp Pro Pro Ala Ala Ser Ala Leu Pro 
65                  70                  75                  80  


Ala Ala Leu Ala Val Ile Ser Phe Leu Leu Gly Leu Gly Leu Gly Val 
                85                  90                  95      


Ala Cys Val Leu Ala Arg Thr Gln Val Ser Val Ser Pro Ser Cys His 
            100                 105                 110         


Leu His Pro Lys Asp Cys Ser Leu Ser 
        115                 120     


<210>  2413
<211>  188
<212>  PRT
<213>  Homo Sapiens

<400>  2413

Met Pro Gly Gly Pro Gly Val Leu Gln Ala Leu Pro Ala Thr Ile Phe 
1               5                   10                  15      


Leu Leu Phe Leu Leu Ser Ala Val Tyr Leu Gly Pro Gly Cys Gln Ala 
            20                  25                  30          


Leu Trp Met His Lys Val Pro Ala Ser Leu Met Val Ser Leu Gly Glu 
        35                  40                  45              


Asp Ala His Phe Gln Cys Pro His Asn Ser Ser Asn Asn Ala Asn Val 
    50                  55                  60                  


Thr Trp Trp Arg Val Leu His Gly Asn Tyr Thr Trp Pro Pro Glu Phe 
65                  70                  75                  80  


Leu Gly Pro Gly Glu Asp Pro Asn Glu Pro Pro Pro Arg Pro Phe Leu 
                85                  90                  95      


Asp Met Gly Glu Gly Thr Lys Asn Arg Ile Ile Thr Ala Glu Gly Ile 
            100                 105                 110         


Ile Leu Leu Phe Cys Ala Val Val Pro Gly Thr Leu Leu Leu Phe Arg 
        115                 120                 125             


Lys Arg Trp Gln Asn Glu Lys Leu Gly Leu Asp Ala Gly Asp Glu Tyr 
    130                 135                 140                 


Glu Asp Glu Asn Leu Tyr Glu Gly Leu Asn Leu Asp Asp Cys Ser Met 
145                 150                 155                 160 


Tyr Glu Asp Ile Ser Arg Gly Leu Gln Gly Thr Tyr Gln Asp Val Gly 
                165                 170                 175     


Ser Leu Asn Ile Gly Asp Val Gln Leu Glu Lys Pro 
            180                 185             


<210>  2414
<211>  226
<212>  PRT
<213>  Homo Sapiens

<400>  2414

Met Pro Gly Gly Pro Gly Val Leu Gln Ala Leu Pro Ala Thr Ile Phe 
1               5                   10                  15      


Leu Leu Phe Leu Leu Ser Ala Val Tyr Leu Gly Pro Gly Cys Gln Ala 
            20                  25                  30          


Leu Trp Met His Lys Val Pro Ala Ser Leu Met Val Ser Leu Gly Glu 
        35                  40                  45              


Asp Ala His Phe Gln Cys Pro His Asn Ser Ser Asn Asn Ala Asn Val 
    50                  55                  60                  


Thr Trp Trp Arg Val Leu His Gly Asn Tyr Thr Trp Pro Pro Glu Phe 
65                  70                  75                  80  


Leu Gly Pro Gly Glu Asp Pro Asn Gly Thr Leu Ile Ile Gln Asn Val 
                85                  90                  95      


Asn Lys Ser His Gly Gly Ile Tyr Val Cys Arg Val Gln Glu Gly Asn 
            100                 105                 110         


Glu Ser Tyr Gln Gln Ser Cys Gly Thr Tyr Leu Arg Val Arg Gln Pro 
        115                 120                 125             


Pro Pro Arg Pro Phe Leu Asp Met Gly Glu Gly Thr Lys Asn Arg Ile 
    130                 135                 140                 


Ile Thr Ala Glu Gly Ile Ile Leu Leu Phe Cys Ala Val Val Pro Gly 
145                 150                 155                 160 


Thr Leu Leu Leu Phe Arg Lys Arg Trp Gln Asn Glu Lys Leu Gly Leu 
                165                 170                 175     


Asp Ala Gly Asp Glu Tyr Glu Asp Glu Asn Leu Tyr Glu Gly Leu Asn 
            180                 185                 190         


Leu Asp Asp Cys Ser Met Tyr Glu Asp Ile Ser Arg Gly Leu Gln Gly 
        195                 200                 205             


Thr Tyr Gln Asp Val Gly Ser Leu Asn Ile Gly Asp Val Gln Leu Glu 
    210                 215                 220                 


Lys Pro 
225     


<210>  2415
<211>  258
<212>  PRT
<213>  Homo Sapiens

<400>  2415

Met Pro Gly Gly Pro Gly Val Leu Gln Ala Leu Pro Ala Thr Ile Phe 
1               5                   10                  15      


Leu Leu Phe Leu Leu Ser Ala Val Tyr Leu Gly Pro Gly Cys Gln Ala 
            20                  25                  30          


Leu Trp Met His Lys Val Pro Ala Ser Leu Met Val Ser Leu Gly Glu 
        35                  40                  45              


Asp Ala His Phe Gln Cys Pro His Asn Ser Ser Asn Asn Ala Asn Val 
    50                  55                  60                  


Thr Trp Trp Arg Val Leu His Gly Asn Tyr Thr Trp Pro Pro Glu Phe 
65                  70                  75                  80  


Leu Gly Pro Gly Glu Asp Pro Asn Gly Thr Leu Ile Ile Gln Asn Val 
                85                  90                  95      


Asn Lys Ser His Gly Gly Ile Tyr Val Cys Arg Val Gln Glu Gly Asn 
            100                 105                 110         


Glu Ser Tyr Gln Gln Ser Cys Gly Thr Tyr Leu Arg Val Arg Arg Glu 
        115                 120                 125             


Trp Pro Ser Pro Gly Pro Tyr Ser His Cys Pro Ala Gly Asp Thr Arg 
    130                 135                 140                 


Phe Ile Phe Glu Val Gly Ile Glu Pro Val Pro Ser Met Trp Val Ser 
145                 150                 155                 160 


Asn Arg Leu Gly Gln Arg Asp Gly His Ser Pro Leu Gln Ser Gly Val 
                165                 170                 175     


Ser Gly Gly Ser Gly Ala Leu Gln Glu Val Gly Gly Ala Arg Arg Leu 
            180                 185                 190         


Gly Arg Ala Arg Gly Ala Arg Ala Leu Ser His Thr Thr Ser Leu Gln 
        195                 200                 205             


Ser Arg Pro Pro Gly Pro Ser Trp Thr Trp Gly Arg Ala Pro Arg Thr 
    210                 215                 220                 


Glu Ser Ser Gln Pro Arg Gly Ser Ser Ser Cys Ser Ala Arg Trp Cys 
225                 230                 235                 240 


Leu Gly Arg Cys Cys Cys Ser Gly Asn Asp Gly Arg Thr Arg Ser Ser 
                245                 250                 255     


Gly Trp 
        


<210>  2416
<211>  256
<212>  PRT
<213>  Homo Sapiens

<400>  2416

Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr 
1               5                   10                  15      


Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys 
            20                  25                  30          


Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu 
        35                  40                  45              


Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile 
    50                  55                  60                  


Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp 
65                  70                  75                  80  


Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr 
                85                  90                  95      


Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly 
            100                 105                 110         


Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg 
        115                 120                 125             


Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr 
    130                 135                 140                 


Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile 
145                 150                 155                 160 


Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu 
                165                 170                 175     


Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp 
            180                 185                 190         


Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met 
        195                 200                 205             


Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg 
    210                 215                 220                 


Val Asn Gln Thr Phe Asn Trp Asn Thr Ser Phe Ala Pro Arg Cys Arg 
225                 230                 235                 240 


Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val 
                245                 250                 255     


<210>  2417
<211>  288
<212>  PRT
<213>  Homo Sapiens

<400>  2417

Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr 
1               5                   10                  15      


Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys 
            20                  25                  30          


Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu 
        35                  40                  45              


Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile 
    50                  55                  60                  


Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp 
65                  70                  75                  80  


Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr 
                85                  90                  95      


Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly 
            100                 105                 110         


Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg 
        115                 120                 125             


Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr 
    130                 135                 140                 


Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile 
145                 150                 155                 160 


Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu 
                165                 170                 175     


Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp 
            180                 185                 190         


Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met 
        195                 200                 205             


Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg 
    210                 215                 220                 


Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro 
225                 230                 235                 240 


Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly 
                245                 250                 255     


Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg 
            260                 265                 270         


Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val 
        275                 280                 285             


<210>  2418
<211>  288
<212>  PRT
<213>  Homo Sapiens

<400>  2418

Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr 
1               5                   10                  15      


Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys 
            20                  25                  30          


Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu 
        35                  40                  45              


Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile 
    50                  55                  60                  


Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp 
65                  70                  75                  80  


Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr 
                85                  90                  95      


Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly 
            100                 105                 110         


Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg 
        115                 120                 125             


Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr 
    130                 135                 140                 


Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile 
145                 150                 155                 160 


Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu 
                165                 170                 175     


Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp 
            180                 185                 190         


Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met 
        195                 200                 205             


Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg 
    210                 215                 220                 


Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro 
225                 230                 235                 240 


Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly 
                245                 250                 255     


Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg 
            260                 265                 270         


Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val 
        275                 280                 285             


<210>  2419
<211>  217
<212>  PRT
<213>  Homo Sapiens

<400>  2419

Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val Met 
1               5                   10                  15      


Ala Phe Leu Leu Ser Ala Asn Phe Ser Gln Pro Glu Ile Val Pro Ile 
            20                  25                  30          


Ser Asn Ile Thr Glu Asn Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile 
        35                  40                  45              


His Gly Tyr Pro Glu Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys 
    50                  55                  60                  


Asn Ser Thr Ile Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn 
65                  70                  75                  80  


Val Thr Glu Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro 
                85                  90                  95      


Asp Val Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys 
            100                 105                 110         


Thr Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
        115                 120                 125             


Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr Val 
    130                 135                 140                 


Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp Lys Lys 
145                 150                 155                 160 


Lys Lys Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr Asn Thr Met Glu 
                165                 170                 175     


Arg Glu Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys Ile His Ile Pro 
            180                 185                 190         


Glu Arg Ser Asp Glu Ala Gln Arg Val Phe Lys Ser Ser Lys Thr Ser 
        195                 200                 205             


Ser Cys Asp Lys Ser Asp Thr Cys Phe 
    210                 215         


<210>  2420
<211>  329
<212>  PRT
<213>  Homo Sapiens

<400>  2420

Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val Met 
1               5                   10                  15      


Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe 
            20                  25                  30          


Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln 
        35                  40                  45              


Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln Glu Asn Leu Val 
    50                  55                  60                  


Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe Asp Ser Val His Ser 
65                  70                  75                  80  


Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg 
                85                  90                  95      


Leu His Asn Leu Gln Ile Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile 
            100                 105                 110         


His His Lys Lys Pro Thr Gly Met Ile Arg Ile His Gln Met Asn Ser 
        115                 120                 125             


Glu Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Val Pro Ile 
    130                 135                 140                 


Ser Asn Ile Thr Glu Asn Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile 
145                 150                 155                 160 


His Gly Tyr Pro Glu Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys 
                165                 170                 175     


Asn Ser Thr Ile Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn 
            180                 185                 190         


Val Thr Glu Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro 
        195                 200                 205             


Asp Val Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys 
    210                 215                 220                 


Thr Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
225                 230                 235                 240 


Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr Val 
                245                 250                 255     


Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp Lys Lys 
            260                 265                 270         


Lys Lys Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr Asn Thr Met Glu 
        275                 280                 285             


Arg Glu Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys Ile His Ile Pro 
    290                 295                 300                 


Glu Arg Ser Asp Glu Ala Gln Arg Val Phe Lys Ser Ser Lys Thr Ser 
305                 310                 315                 320 


Ser Cys Asp Lys Ser Asp Thr Cys Phe 
                325                 


<210>  2421
<211>  167
<212>  PRT
<213>  Homo Sapiens

<400>  2421

Met Gly Leu Ser Asn Ile Leu Phe Val Met Ala Phe Leu Leu Ser Gly 
1               5                   10                  15      


Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu 
            20                  25                  30          


Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val 
        35                  40                  45              


Val Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu 
    50                  55                  60                  


Gly Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr 
65                  70                  75                  80  


Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile 
                85                  90                  95      


Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr 
            100                 105                 110         


Gly Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala 
        115                 120                 125             


Asn Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
    130                 135                 140                 


Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro 
145                 150                 155                 160 


Lys Lys Met Ser Val Leu Leu 
                165         


<210>  2422
<211>  323
<212>  PRT
<213>  Homo Sapiens

<400>  2422

Met Gly Leu Ser Asn Ile Leu Phe Val Met Ala Phe Leu Leu Ser Gly 
1               5                   10                  15      


Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu 
            20                  25                  30          


Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val 
        35                  40                  45              


Val Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu 
    50                  55                  60                  


Gly Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr 
65                  70                  75                  80  


Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile 
                85                  90                  95      


Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr 
            100                 105                 110         


Gly Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala 
        115                 120                 125             


Asn Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
    130                 135                 140                 


Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro 
145                 150                 155                 160 


Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr 
                165                 170                 175     


Asp Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp 
            180                 185                 190         


Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met 
        195                 200                 205             


Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser 
    210                 215                 220                 


Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile 
225                 230                 235                 240 


Pro Trp Ile Thr Ala Val Leu Pro Thr Val Ile Ile Cys Val Met Val 
                245                 250                 255     


Phe Cys Leu Ile Leu Trp Lys Trp Lys Lys Lys Lys Arg Pro Arg Asn 
            260                 265                 270         


Ser Tyr Lys Cys Gly Thr Asn Thr Met Glu Arg Glu Glu Ser Glu Gln 
        275                 280                 285             


Thr Lys Lys Arg Glu Lys Ile His Ile Pro Glu Arg Ser Asp Glu Ala 
    290                 295                 300                 


Gln Arg Val Phe Lys Ser Ser Lys Thr Ser Ser Cys Asp Lys Ser Asp 
305                 310                 315                 320 


Thr Cys Phe 
            


<210>  2423
<211>  275
<212>  PRT
<213>  Homo Sapiens

<400>  2423

Met Gly Leu Ser Asn Ile Leu Phe Val Met Ala Phe Leu Leu Ser Gly 
1               5                   10                  15      


Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu 
            20                  25                  30          


Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val 
        35                  40                  45              


Val Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu 
    50                  55                  60                  


Gly Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr 
65                  70                  75                  80  


Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile 
                85                  90                  95      


Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr 
            100                 105                 110         


Gly Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala 
        115                 120                 125             


Asn Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
    130                 135                 140                 


Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro 
145                 150                 155                 160 


Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr 
                165                 170                 175     


Asp Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp 
            180                 185                 190         


Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met 
        195                 200                 205             


Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser 
    210                 215                 220                 


Pro Phe Ser Ile Gly Thr Asn Thr Met Glu Arg Glu Glu Ser Glu Gln 
225                 230                 235                 240 


Thr Lys Lys Arg Glu Lys Ile His Ile Pro Glu Arg Ser Asp Glu Ala 
                245                 250                 255     


Gln Arg Val Phe Lys Ser Ser Lys Thr Ser Ser Cys Asp Lys Ser Asp 
            260                 265                 270         


Thr Cys Phe 
        275 


<210>  2424
<211>  247
<212>  PRT
<213>  Homo Sapiens

<400>  2424

Met Gly Arg Thr Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His 
1               5                   10                  15      


Asn Leu Gln Ile Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His 
            20                  25                  30          


Lys Lys Pro Thr Gly Met Ile Arg Ile His Gln Met Asn Ser Glu Leu 
        35                  40                  45              


Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn 
    50                  55                  60                  


Ile Thr Glu Asn Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly 
65                  70                  75                  80  


Tyr Pro Glu Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser 
                85                  90                  95      


Thr Ile Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr 
            100                 105                 110         


Glu Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val 
        115                 120                 125             


Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg 
    130                 135                 140                 


Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro 
145                 150                 155                 160 


Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr Val Ile Ile 
                165                 170                 175     


Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp Lys Lys Lys Lys 
            180                 185                 190         


Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr Asn Thr Met Glu Arg Glu 
        195                 200                 205             


Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys Ile His Ile Pro Glu Arg 
    210                 215                 220                 


Ser Asp Glu Ala Gln Arg Val Phe Lys Ser Ser Lys Thr Ser Ser Cys 
225                 230                 235                 240 


Asp Lys Ser Asp Thr Cys Phe 
                245         


<210>  2425
<211>  277
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2425

Xaa Thr Met Gly Leu Ser Asn Ile Leu Phe Val Met Ala Phe Leu Leu 
1               5                   10                  15      


Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala 
            20                  25                  30          


Asp Leu Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu 
        35                  40                  45              


Leu Val Val Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val 
    50                  55                  60                  


Tyr Leu Gly Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly 
65                  70                  75                  80  


Arg Thr Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu 
                85                  90                  95      


Gln Ile Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys 
            100                 105                 110         


Pro Thr Gly Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val 
        115                 120                 125             


Leu Ala Asn Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr 
    130                 135                 140                 


Glu Asn Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro 
145                 150                 155                 160 


Glu Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile 
                165                 170                 175     


Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu 
            180                 185                 190         


Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser 
        195                 200                 205             


Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu 
    210                 215                 220                 


Ser Ser Pro Phe Ser Ile Gly Thr Asn Thr Met Glu Arg Glu Glu Ser 
225                 230                 235                 240 


Glu Gln Thr Lys Lys Arg Glu Lys Ile His Ile Pro Glu Arg Ser Asp 
                245                 250                 255     


Glu Ala Gln Arg Val Phe Lys Ser Ser Lys Thr Ser Ser Cys Asp Lys 
            260                 265                 270         


Ser Asp Thr Cys Phe 
        275         


<210>  2426
<211>  198
<212>  PRT
<213>  Homo Sapiens

<400>  2426

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Gly Asn Arg Arg Arg 
                165                 170                 175     


Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser Gly Asp Lys Pro Ser 
            180                 185                 190         


Leu Ser Ala Arg Tyr Val 
        195             


<210>  2427
<211>  235
<212>  PRT
<213>  Homo Sapiens

<400>  2427

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            180                 185                 190         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
        195                 200                 205             


Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser 
    210                 215                 220                 


Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
225                 230                 235 


<210>  2428
<211>  235
<212>  PRT
<213>  Homo Sapiens

<400>  2428

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            180                 185                 190         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
        195                 200                 205             


Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser 
    210                 215                 220                 


Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
225                 230                 235 


<210>  2429
<211>  198
<212>  PRT
<213>  Homo Sapiens

<400>  2429

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    130                 135                 140                 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
145                 150                 155                 160 


Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Arg Arg 
                165                 170                 175     


Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser Gly Asp Lys Pro Ser 
            180                 185                 190         


Leu Ser Ala Arg Tyr Val 
        195             


<210>  2430
<211>  198
<212>  PRT
<213>  Homo Sapiens

<400>  2430

Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Thr Val Leu 
1               5                   10                  15      


His Gly Asn Ser Val Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln 
            20                  25                  30          


Thr Asn Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser 
        35                  40                  45              


Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp 
    50                  55                  60                  


Ser His His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile 
65                  70                  75                  80  


His Gly Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala 
                85                  90                  95      


Ser Arg Phe Ile Leu Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly 
            100                 105                 110         


Ile Tyr Phe Cys Met Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys 
        115                 120                 125             


Gly Thr Gln Leu Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro 
    130                 135                 140                 


Thr Lys Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro 
145                 150                 155                 160 


Glu Thr Gln Lys Gly Leu Lys Gly Lys Val Tyr Gln Glu Pro Leu Ser 
                165                 170                 175     


Pro Asn Ala Cys Met Asp Thr Thr Ala Ile Leu Gln Pro His Arg Ser 
            180                 185                 190         


Cys Leu Thr His Gly Ser 
        195             


<210>  2431
<211>  210
<212>  PRT
<213>  Homo Sapiens

<400>  2431

Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Thr Val Leu 
1               5                   10                  15      


His Gly Asn Ser Val Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln 
            20                  25                  30          


Thr Asn Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser 
        35                  40                  45              


Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp 
    50                  55                  60                  


Ser His His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile 
65                  70                  75                  80  


His Gly Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala 
                85                  90                  95      


Ser Arg Phe Ile Leu Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly 
            100                 105                 110         


Ile Tyr Phe Cys Met Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys 
        115                 120                 125             


Gly Thr Gln Leu Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro 
    130                 135                 140                 


Thr Lys Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro 
145                 150                 155                 160 


Glu Thr Gln Lys Gly Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu 
                165                 170                 175     


Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly Val Ala Ile His 
            180                 185                 190         


Leu Cys Cys Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Phe 
        195                 200                 205             


Tyr Lys 
    210 


<210>  2432
<211>  221
<212>  PRT
<213>  Homo Sapiens

<400>  2432

Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Thr Val Leu 
1               5                   10                  15      


His Gly Asn Ser Val Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln 
            20                  25                  30          


Thr Asn Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser 
        35                  40                  45              


Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp 
    50                  55                  60                  


Ser His His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile 
65                  70                  75                  80  


His Gly Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala 
                85                  90                  95      


Ser Arg Phe Ile Leu Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly 
            100                 105                 110         


Ile Tyr Phe Cys Met Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys 
        115                 120                 125             


Gly Thr Gln Leu Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro 
    130                 135                 140                 


Thr Lys Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro 
145                 150                 155                 160 


Glu Thr Gln Lys Gly Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu 
                165                 170                 175     


Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly Val Ala Ile His 
            180                 185                 190         


Leu Cys Cys Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Leu 
        195                 200                 205             


Arg Leu His Pro Leu Glu Lys Cys Ser Arg Met Asp Tyr 
    210                 215                 220     


<210>  2433
<211>  210
<212>  PRT
<213>  Homo Sapiens

<400>  2433

Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Thr Val Leu 
1               5                   10                  15      


His Gly Asn Ser Val Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln 
            20                  25                  30          


Thr Asn Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser 
        35                  40                  45              


Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp 
    50                  55                  60                  


Ser His His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile 
65                  70                  75                  80  


His Gly Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala 
                85                  90                  95      


Ser Arg Phe Ile Leu Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly 
            100                 105                 110         


Ile Tyr Phe Cys Met Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys 
        115                 120                 125             


Gly Thr Gln Leu Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro 
    130                 135                 140                 


Thr Lys Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro 
145                 150                 155                 160 


Glu Thr Gln Lys Gly Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu 
                165                 170                 175     


Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly Val Ala Ile His 
            180                 185                 190         


Leu Cys Cys Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Leu 
        195                 200                 205             


Tyr Lys 
    210 


<210>  2434
<211>  243
<212>  PRT
<213>  Homo Sapiens

<400>  2434

Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Thr Val Leu 
1               5                   10                  15      


His Gly Asn Ser Val Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln 
            20                  25                  30          


Thr Asn Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser 
        35                  40                  45              


Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp 
    50                  55                  60                  


Ser His His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile 
65                  70                  75                  80  


His Gly Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala 
                85                  90                  95      


Ser Arg Phe Ile Leu Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly 
            100                 105                 110         


Ile Tyr Phe Cys Met Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys 
        115                 120                 125             


Gly Thr Gln Leu Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro 
    130                 135                 140                 


Thr Lys Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro 
145                 150                 155                 160 


Glu Thr Gln Lys Gly Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu 
                165                 170                 175     


Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly Val Ala Ile His 
            180                 185                 190         


Leu Cys Cys Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Pro 
        195                 200                 205             


Gln Gly Glu Gly Ile Ser Gly Thr Phe Val Pro Gln Cys Leu His Gly 
    210                 215                 220                 


Tyr Tyr Ser Asn Thr Thr Thr Ser Gln Lys Leu Leu Asn Pro Trp Ile 
225                 230                 235                 240 


Leu Lys Thr 
            


<210>  2435
<211>  213
<212>  PRT
<213>  Homo Sapiens

<400>  2435

Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Thr Val Leu 
1               5                   10                  15      


His Gly Asn Ser Val Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln 
            20                  25                  30          


Thr Asn Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser 
        35                  40                  45              


Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp 
    50                  55                  60                  


Ser His His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile 
65                  70                  75                  80  


His Gly Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala 
                85                  90                  95      


Ser Arg Phe Ile Leu Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly 
            100                 105                 110         


Ile Tyr Phe Cys Met Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys 
        115                 120                 125             


Gly Thr Gln Leu Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro 
    130                 135                 140                 


Thr Lys Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro 
145                 150                 155                 160 


Glu Thr Gln Lys Gly Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys 
                165                 170                 175     


Gln Pro Gln Gly Glu Gly Ile Ser Gly Thr Phe Val Pro Gln Cys Leu 
            180                 185                 190         


His Gly Tyr Tyr Ser Asn Thr Thr Thr Ser Gln Lys Leu Leu Asn Pro 
        195                 200                 205             


Trp Ile Leu Lys Thr 
    210             


<210>  2436
<211>  185
<212>  PRT
<213>  Homo Sapiens

<400>  2436

Met Ala Arg Gly Ala Ala Leu Ala Leu Leu Leu Phe Gly Leu Leu Gly 
1               5                   10                  15      


Val Leu Val Ala Ala Pro Asp Gly Gly Phe Asp Leu Ser Asp Ala Leu 
            20                  25                  30          


Pro Asp Asn Glu Asn Lys Lys Pro Thr Ala Ile Pro Lys Lys Pro Ser 
        35                  40                  45              


Ala Gly Asp Asp Phe Asp Leu Gly Asp Ala Val Val Asp Gly Glu Asn 
    50                  55                  60                  


Asp Asp Pro Arg Pro Pro Asn Pro Pro Lys Pro Met Pro Asn Pro Asn 
65                  70                  75                  80  


Pro Asn His Pro Ser Ser Ser Gly Ser Phe Ser Asp Ala Asp Leu Ala 
                85                  90                  95      


Asp Gly Val Ser Gly Gly Glu Gly Lys Gly Gly Ser Asp Gly Gly Gly 
            100                 105                 110         


Ser His Arg Lys Glu Gly Glu Glu Ala Asp Ala Pro Gly Val Ile Pro 
        115                 120                 125             


Gly Ile Val Gly Ala Val Val Val Ala Val Ala Gly Ala Ile Ser Ser 
    130                 135                 140                 


Phe Ile Ala Tyr Gln Lys Lys Lys Leu Cys Phe Lys Glu Asn Ala Glu 
145                 150                 155                 160 


Gln Gly Glu Val Asp Met Glu Ser His Arg Asn Ala Asn Ala Glu Pro 
                165                 170                 175     


Ala Val Gln Arg Thr Leu Leu Glu Lys 
            180                 185 


<210>  2437
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  2437

Met Ala Arg Gly Ala Ala Leu Ala Leu Leu Leu Phe Gly Leu Leu Gly 
1               5                   10                  15      


Val Leu Val Ala Ala Pro Asp Gly Gly Phe Asp Leu Ser Asp Ala Leu 
            20                  25                  30          


Pro Asp Asn Glu Asn Lys Lys Pro Thr Ala Ile Pro Lys Lys Pro Ser 
        35                  40                  45              


Ala Gly Asp Asp Phe Asp Leu Gly Asp Ala Val Val Asp Gly Glu Asn 
    50                  55                  60                  


Asp Asp Pro Arg Pro Pro Asn Pro Pro Lys Pro Met Pro Asn Pro Asn 
65                  70                  75                  80  


Pro Asn His Pro Ser Ser Ser Gly Ser Phe Ser Asp Ala Asp Leu Ala 
                85                  90                  95      


Asp Gly Val Ser Gly Gly Glu Gly Lys Gly Gly Ser Asp Gly Gly Gly 
            100                 105                 110         


Ser His Arg Lys Glu Gly Glu Glu Ala Asp Ala Pro Gly Val Ile Pro 
        115                 120                 125             


Gly Ile Val Gly Ala Val Val Val Ala Val Ala Gly Ala Ile Ser Ser 
    130                 135                 140                 


Phe Ile Ala Tyr Gln Lys Lys Lys Leu Cys Phe Lys Glu Asn Asp Gly 
145                 150                 155                 160 


<210>  2438
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  2438

Met Ala Arg Gly Ala Ala Leu Ala Leu Leu Leu Phe Gly Leu Leu Gly 
1               5                   10                  15      


Val Leu Val Ala Ala Pro Asp Gly Gly Phe Asp Leu Ser Asp Ala Leu 
            20                  25                  30          


Pro Asp Asn Glu Asn Lys Lys Pro Thr Ala Ile Pro Lys Lys Pro Ser 
        35                  40                  45              


Ala Gly Asp Asp Phe Asp Leu Gly Asp Ala Val Val Asp Gly Glu Asn 
    50                  55                  60                  


Asp Asp Pro Arg Pro Pro Asn Pro Pro Lys Pro Met Pro Asn Pro Asn 
65                  70                  75                  80  


Pro Asn His Pro Ser Ser Ser Gly Ser Phe Ser Asp Ala Asp Leu Ala 
                85                  90                  95      


Asp Gly Val Ser Gly Gly Glu Gly Lys Gly Gly Ser Asp Gly Gly Gly 
            100                 105                 110         


Ser His Arg Lys Glu Gly Glu Glu Ala Asp Ala Pro Gly Val Ile Pro 
        115                 120                 125             


Gly Ile Val Gly Ala Val Val Val Ala Val Ala Gly Ala Ile Ser Ser 
    130                 135                 140                 


Phe Ile Ala Tyr Gln Lys Lys Lys Leu Cys Phe Lys Glu Asn Asp Gly 
145                 150                 155                 160 


<210>  2439
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  2439

Met Ala Arg Gly Ala Ala Leu Ala Leu Leu Leu Phe Gly Leu Leu Gly 
1               5                   10                  15      


Val Leu Val Ala Ala Pro Asp Gly Gly Phe Asp Leu Ser Asp Ala Leu 
            20                  25                  30          


Pro Asp Asn Glu Asn Lys Lys Pro Thr Ala Ile Pro Lys Lys Pro Ser 
        35                  40                  45              


Ala Gly Asp Asp Phe Asp Leu Gly Asp Ala Val Val Asp Gly Glu Asn 
    50                  55                  60                  


Asp Asp Pro Arg Pro Pro Asn Pro Pro Lys Pro Met Pro Asn Pro Asn 
65                  70                  75                  80  


Pro Asn His Pro Ser Ser Ser Gly Ser Phe Ser Asp Ala Asp Leu Ala 
                85                  90                  95      


Asp Gly Val Ser Gly Gly Glu Gly Lys Gly Gly Ser Asp Gly Gly Gly 
            100                 105                 110         


Ser His Arg Lys Glu Gly Glu Glu Ala Asp Ala Pro Gly Val Ile Pro 
        115                 120                 125             


Gly Ile Val Gly Ala Val Val Val Ala Val Ala Gly Ala Ile Ser Ser 
    130                 135                 140                 


Phe Ile Ala Tyr Gln Lys Lys Lys Leu Cys Phe Lys Glu Asn Asp Gly 
145                 150                 155                 160 


<210>  2440
<211>  184
<212>  PRT
<213>  Homo Sapiens

<400>  2440

Met Ala Arg Gly Ala Ala Leu Ala Leu Leu Leu Phe Gly Leu Leu Gly 
1               5                   10                  15      


Val Leu Val Ala Ala Pro Asp Gly Gly Phe Asp Leu Ser Asp Ala Leu 
            20                  25                  30          


Pro Asp Asn Glu Asn Lys Lys Pro Thr Ala Ile Pro Lys Lys Pro Ser 
        35                  40                  45              


Ala Gly Asp Asp Phe Asp Leu Gly Asp Ala Val Val Asp Gly Glu Asn 
    50                  55                  60                  


Asp Asp Pro Arg Pro Pro Asn Pro Pro Lys Pro Met Pro Asn Pro Asn 
65                  70                  75                  80  


Pro Asn His Pro Ser Ser Ser Gly Ser Phe Ser Asp Ala Asp Leu Ala 
                85                  90                  95      


Asp Gly Val Ser Gly Gly Glu Gly Lys Gly Gly Ser Asp Gly Gly Gly 
            100                 105                 110         


Ser His Arg Lys Glu Gly Glu Glu Ala Asp Ala Pro Gly Val Ile Pro 
        115                 120                 125             


Gly Ile Val Gly Ala Val Val Val Ala Val Ala Gly Ala Ile Ser Ser 
    130                 135                 140                 


Phe Ile Ala Tyr Gln Lys Lys Lys Leu Cys Phe Lys Glu Asn Glu Gln 
145                 150                 155                 160 


Gly Glu Val Asp Met Glu Ser His Arg Asn Ala Asn Ala Glu Pro Ala 
                165                 170                 175     


Val Gln Arg Thr Leu Leu Glu Lys 
            180                 


<210>  2441
<211>  177
<212>  PRT
<213>  Homo Sapiens

<400>  2441

Met Ala Arg Gly Ala Ala Leu Ala Leu Leu Leu Phe Gly Leu Leu Gly 
1               5                   10                  15      


Val Leu Val Ala Ala Pro Asp Gly Gly Phe Asp Leu Ser Asp Ala Leu 
            20                  25                  30          


Pro Asp Asn Glu Asn Lys Lys Pro Thr Ala Ile Pro Lys Lys Pro Ser 
        35                  40                  45              


Ala Gly Asp Asp Phe Asp Leu Gly Asp Ala Val Val Asp Gly Glu Asn 
    50                  55                  60                  


Asp Asp Pro Arg Pro Pro Asn Pro Pro Lys Pro Met Pro Asn Pro Asn 
65                  70                  75                  80  


Pro Asn His Pro Ser Ser Ser Gly Ser Phe Ser Asp Ala Asp Leu Ala 
                85                  90                  95      


Asp Gly Val Ser Gly Gly Glu Gly Lys Gly Gly Ser Asp Gly Gly Gly 
            100                 105                 110         


Ser His Arg Lys Glu Gly Glu Glu Ala Asp Ala Pro Gly Val Ile Pro 
        115                 120                 125             


Gly Ile Val Gly Ala Val Val Val Ala Val Ala Gly Ala Ile Ser Ser 
    130                 135                 140                 


Phe Ile Ala Tyr Gln Lys Lys Lys Leu Cys Phe Lys Glu Asn Gly Gln 
145                 150                 155                 160 


Leu Ala Gly Ser Leu Gly Pro Cys Ile Gly Ile Arg Arg Glu Ala Asp 
                165                 170                 175     


Gly 
    


<210>  2442
<211>  169
<212>  PRT
<213>  Homo Sapiens

<400>  2442

Met Ala Arg Gly Ala Ala Leu Ala Leu Leu Leu Phe Gly Leu Leu Gly 
1               5                   10                  15      


Val Leu Val Ala Ala Pro Asp Gly Gly Phe Asp Leu Ser Asp Ala Leu 
            20                  25                  30          


Pro Gly Asp Asp Phe Asp Leu Gly Asp Ala Val Val Asp Gly Glu Asn 
        35                  40                  45              


Asp Asp Pro Arg Pro Pro Asn Pro Pro Lys Pro Met Pro Asn Pro Asn 
    50                  55                  60                  


Pro Asn His Pro Ser Ser Ser Gly Ser Phe Ser Asp Ala Asp Leu Ala 
65                  70                  75                  80  


Asp Gly Val Ser Gly Gly Glu Gly Lys Gly Gly Ser Asp Gly Gly Gly 
                85                  90                  95      


Ser His Arg Lys Glu Gly Glu Glu Ala Asp Ala Pro Gly Val Ile Pro 
            100                 105                 110         


Gly Ile Val Gly Ala Val Val Val Ala Val Ala Gly Ala Ile Ser Ser 
        115                 120                 125             


Phe Ile Ala Tyr Gln Lys Lys Lys Leu Cys Phe Lys Glu Asn Ala Glu 
    130                 135                 140                 


Gln Gly Glu Val Asp Met Glu Ser His Arg Asn Ala Asn Ala Glu Pro 
145                 150                 155                 160 


Ala Val Gln Arg Thr Leu Leu Glu Lys 
                165                 


<210>  2443
<211>  76
<212>  PRT
<213>  Homo Sapiens

<400>  2443

Met Ala Arg Gly Ala Ala Leu Ala Leu Leu Leu Phe Gly Leu Leu Gly 
1               5                   10                  15      


Val Leu Val Ala Ala Pro Gly Phe Gly Asp Leu Arg Leu Gln Ala Ala 
            20                  25                  30          


Arg Gly Gly Arg Pro Gly Val Ala Cys His Ser His Ala Leu Arg Pro 
        35                  40                  45              


Gly Pro Lys Phe Gly Ile Ala Arg Ser Leu Arg Pro Gly Trp Trp Gly 
    50                  55                  60                  


Glu Gly Lys Glu Lys Leu Glu Lys Asn Phe Glu Pro 
65                  70                  75      


<210>  2444
<211>  22
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2444

Xaa Gln Lys Lys Lys Leu Cys Phe Lys Glu Asn Glu Arg Ala Ser Met 
1               5                   10                  15      


Cys Val Phe Leu Ser Val 
            20          


<210>  2445
<211>  109
<212>  PRT
<213>  Homo Sapiens

<400>  2445

Met Ala Ala Ser Thr Ser Met Val Pro Val Ala Val Thr Ala Ala Val 
1               5                   10                  15      


Ala Pro Val Leu Ser Ile Asn Ser Asp Phe Ser Asp Leu Arg Glu Ile 
            20                  25                  30          


Lys Lys Gln Leu Leu Leu Ile Ala Gly Leu Thr Arg Glu Arg Gly Leu 
        35                  40                  45              


Leu His Ser Ser Lys Trp Lys Met Pro Arg Ile Trp Met Pro Ile Pro 
    50                  55                  60                  


Trp Pro Arg Pro Thr Leu Thr Leu Lys Ser Met Ile Gly Gln His Ile 
65                  70                  75                  80  


Ser Cys Met Ala Ala Ile Ala Arg Lys Pro Ile Phe Cys Ile Cys Ile 
                85                  90                  95      


Pro Asp Ile Trp Pro Pro Gly Lys Arg Thr Ser Glu Lys 
            100                 105                 


<210>  2446
<211>  597
<212>  PRT
<213>  Homo Sapiens

<400>  2446

Met Ala Ala Ser Thr Ser Met Val Pro Val Ala Val Thr Ala Ala Val 
1               5                   10                  15      


Ala Pro Val Leu Ser Ile Asn Ser Asp Phe Ser Asp Leu Arg Glu Ile 
            20                  25                  30          


Lys Lys Gln Leu Leu Leu Ile Ala Gly Leu Thr Arg Glu Arg Gly Leu 
        35                  40                  45              


Leu His Ser Ser Lys Trp Ser Ala Glu Leu Ala Phe Ser Leu Pro Ala 
    50                  55                  60                  


Leu Pro Leu Ala Glu Leu Gln Pro Pro Pro Pro Ile Thr Glu Glu Asp 
65                  70                  75                  80  


Ala Gln Asp Met Asp Ala Tyr Thr Leu Ala Lys Ala Tyr Phe Asp Val 
                85                  90                  95      


Lys Glu Tyr Asp Arg Ala Ala His Phe Leu His Gly Cys Asn Ser Lys 
            100                 105                 110         


Lys Ala Tyr Phe Leu Tyr Met Tyr Ser Arg Tyr Leu Ser Gly Glu Lys 
        115                 120                 125             


Lys Lys Asp Asp Glu Thr Val Asp Ser Leu Gly Pro Leu Glu Lys Gly 
    130                 135                 140                 


Gln Val Lys Asn Glu Ala Leu Arg Glu Leu Arg Val Glu Leu Ser Lys 
145                 150                 155                 160 


Lys His Gln Ala Arg Glu Leu Asp Gly Phe Gly Leu Tyr Leu Tyr Gly 
                165                 170                 175     


Val Val Leu Arg Lys Leu Asp Leu Val Lys Glu Ala Ile Asp Val Phe 
            180                 185                 190         


Val Glu Ala Thr His Val Leu Pro Leu His Trp Gly Ala Trp Leu Glu 
        195                 200                 205             


Leu Cys Asn Leu Ile Thr Asp Lys Glu Met Leu Lys Phe Leu Ser Leu 
    210                 215                 220                 


Pro Asp Thr Trp Met Lys Glu Phe Phe Leu Ala His Ile Tyr Thr Glu 
225                 230                 235                 240 


Leu Gln Leu Ile Glu Glu Ala Leu Gln Lys Tyr Gln Asn Leu Ile Asp 
                245                 250                 255     


Val Gly Phe Ser Lys Ser Ser Tyr Ile Val Ser Gln Ile Ala Val Ala 
            260                 265                 270         


Tyr His Asn Ile Arg Asp Ile Asp Lys Ala Leu Ser Ile Phe Asn Glu 
        275                 280                 285             


Leu Arg Lys Gln Asp Pro Tyr Arg Ile Glu Asn Met Asp Thr Phe Ser 
    290                 295                 300                 


Asn Leu Leu Tyr Val Arg Ser Met Lys Ser Glu Leu Ser Tyr Leu Ala 
305                 310                 315                 320 


His Asn Leu Cys Glu Ile Asp Lys Tyr Arg Val Glu Thr Cys Cys Val 
                325                 330                 335     


Ile Gly Asn Tyr Tyr Ser Leu Arg Ser Gln His Glu Lys Ala Ala Leu 
            340                 345                 350         


Tyr Phe Gln Arg Ala Leu Lys Leu Asn Pro Arg Tyr Leu Gly Ala Trp 
        355                 360                 365             


Thr Leu Met Gly His Glu Tyr Met Glu Met Lys Asn Thr Ser Ala Ala 
    370                 375                 380                 


Ile Gln Ala Tyr Arg His Ala Ile Glu Val Asn Lys Arg Asp Tyr Arg 
385                 390                 395                 400 


Ala Trp Tyr Gly Leu Gly Gln Thr Tyr Glu Ile Leu Lys Met Pro Phe 
                405                 410                 415     


Tyr Cys Leu Tyr Tyr Tyr Arg Arg Ala His Gln Leu Arg Pro Asn Asp 
            420                 425                 430         


Ser Arg Met Leu Val Ala Leu Gly Glu Cys Tyr Glu Lys Leu Asn Gln 
        435                 440                 445             


Leu Val Glu Ala Lys Lys Cys Tyr Trp Arg Ala Tyr Ala Val Gly Asp 
    450                 455                 460                 


Val Glu Lys Met Ala Leu Val Lys Leu Ala Lys Leu His Glu Gln Leu 
465                 470                 475                 480 


Thr Glu Ser Glu Gln Ala Ala Gln Cys Tyr Ile Lys Tyr Ile Gln Asp 
                485                 490                 495     


Ile Tyr Ser Cys Gly Glu Ile Val Glu His Leu Glu Glu Ser Thr Ala 
            500                 505                 510         


Phe Arg Tyr Leu Ala Gln Tyr Tyr Phe Lys Cys Lys Leu Trp Asp Glu 
        515                 520                 525             


Ala Ser Thr Cys Ala Gln Lys Cys Cys Ala Phe Asn Asp Thr Arg Glu 
    530                 535                 540                 


Glu Gly Lys Ala Leu Leu Arg Gln Ile Leu Gln Leu Arg Asn Gln Gly 
545                 550                 555                 560 


Glu Thr Pro Thr Thr Glu Val Pro Ala Pro Phe Phe Leu Pro Ala Ser 
                565                 570                 575     


Leu Ser Ala Asn Asn Thr Pro Thr Arg Arg Val Ser Pro Leu Asn Leu 
            580                 585                 590         


Ser Ser Val Thr Pro 
        595         


<210>  2447
<211>  151
<212>  PRT
<213>  Homo Sapiens

<400>  2447

Met Ala Ala Ser Thr Ser Met Val Pro Val Ala Val Thr Ala Ala Val 
1               5                   10                  15      


Ala Pro Val Leu Ser Ile Asn Ser Asp Phe Ser Asp Leu Arg Glu Ile 
            20                  25                  30          


Lys Lys Gln Leu Leu Leu Ile Ala Gly Leu Thr Arg Glu Arg Gly Leu 
        35                  40                  45              


Leu His Ser Ser Lys Trp Ser Ala Glu Leu Ala Phe Ser Leu Pro Ala 
    50                  55                  60                  


Leu Pro Leu Ala Glu Leu Gln Pro Pro Pro Pro Ile Thr Glu Glu Asp 
65                  70                  75                  80  


Ala Gln Asp Met Asp Ala Tyr Thr Leu Ala Lys Ala Tyr Phe Asp Val 
                85                  90                  95      


Lys Glu Tyr Asp Arg Ala Ala His Phe Leu His Gly Cys Asn Ser Lys 
            100                 105                 110         


Lys Ala Tyr Phe Leu Tyr Met Tyr Ser Arg Tyr Leu Val Arg Ala Ile 
        115                 120                 125             


Leu Lys Cys His Ser Ala Phe Ser Glu Thr Ser Ile Phe Arg Thr Asn 
    130                 135                 140                 


Gly Lys Val Lys Ser Phe Lys 
145                 150     


<210>  2448
<211>  123
<212>  PRT
<213>  Homo Sapiens

<400>  2448

Met Ala Ala Ser Thr Ser Met Val Pro Val Ala Val Thr Ala Ala Val 
1               5                   10                  15      


Ala Pro Val Leu Ser Ile Asn Ser Asp Phe Ser Asp Leu Arg Glu Ile 
            20                  25                  30          


Lys Lys Gln Leu Leu Leu Ile Ala Gly Leu Thr Arg Glu Arg Gly Leu 
        35                  40                  45              


Leu His Ser Ser Lys Trp Ser Ala Glu Leu Ala Phe Ser Leu Pro Ala 
    50                  55                  60                  


Leu Pro Leu Ala Glu Leu Gln Pro Pro Pro Pro Ile Thr Glu Met Pro 
65                  70                  75                  80  


Arg Ile Trp Met Pro Ile Pro Trp Pro Arg Pro Thr Leu Thr Leu Lys 
                85                  90                  95      


Ser Met Ile Gly Gln His Ile Ser Cys Met Ala Ala Ile Ala Arg Lys 
            100                 105                 110         


Pro Ile Phe Cys Ile Cys Ile Pro Asp Ile Trp 
        115                 120             


<210>  2449
<211>  134
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2449

Xaa Ser Thr Ser Met Val Pro Val Ala Val Thr Ala Ala Val Ala Pro 
1               5                   10                  15      


Val Leu Ser Ile Asn Ser Asp Phe Ser Asp Leu Arg Glu Ile Lys Lys 
            20                  25                  30          


Gln Leu Leu Leu Ile Ala Gly Leu Thr Arg Glu Arg Gly Leu Leu His 
        35                  40                  45              


Ser Ser Lys Trp Ser Ala Glu Leu Ala Phe Ser Leu Pro Ala Leu Pro 
    50                  55                  60                  


Leu Ala Glu Leu Gln Pro Pro Pro Pro Ile Thr Glu Met Pro Arg Ile 
65                  70                  75                  80  


Trp Met Pro Ile Pro Trp Pro Arg Pro Thr Leu Thr Leu Lys Ser Met 
                85                  90                  95      


Ile Gly Gln His Ile Ser Cys Met Ala Ala Ile Ala Arg Lys Pro Ile 
            100                 105                 110         


Phe Cys Ile Cys Ile Pro Asp Ile Cys Leu Glu Lys Lys Arg Arg Thr 
        115                 120                 125             


Met Lys Gln Leu Ile Ala 
    130                 


<210>  2450
<211>  579
<212>  PRT
<213>  Homo Sapiens

<400>  2450

Met Ser Ala Ala Ile Ala Ala Leu Ala Ala Ser Tyr Gly Ser Gly Ser 
1               5                   10                  15      


Gly Ser Glu Ser Asp Ser Asp Ser Glu Ser Ser Arg Cys Pro Leu Pro 
            20                  25                  30          


Ala Ala Asp Ser Leu Met His Leu Thr Lys Ser Pro Ser Ser Lys Pro 
        35                  40                  45              


Ser Leu Ala Val Ala Val Asp Ser Ala Pro Glu Val Ala Val Lys Glu 
    50                  55                  60                  


Asp Leu Glu Thr Gly Val His Leu Asp Pro Ala Val Lys Glu Val Gln 
65                  70                  75                  80  


Tyr Asn Pro Thr Tyr Glu Thr Met Phe Ala Pro Glu Phe Gly Pro Glu 
                85                  90                  95      


Asn Pro Phe Arg Thr Gln Gln Met Ala Ala Pro Arg Asn Met Leu Ser 
            100                 105                 110         


Gly Tyr Ala Glu Pro Ala His Ile Asn Asp Phe Met Phe Glu Gln Gln 
        115                 120                 125             


Arg Arg Thr Phe Ala Thr Tyr Gly Tyr Ala Leu Asp Pro Ser Leu Asp 
    130                 135                 140                 


Asn His Gln Val Ser Ala Lys Tyr Ile Gly Ser Val Glu Glu Ala Glu 
145                 150                 155                 160 


Lys Asn Gln Gly Leu Thr Val Phe Glu Thr Gly Gln Lys Lys Thr Glu 
                165                 170                 175     


Lys Arg Lys Lys Phe Lys Glu Asn Asp Ala Ser Asn Ile Asp Gly Phe 
            180                 185                 190         


Leu Gly Pro Trp Ala Lys Tyr Val Asp Glu Lys Asp Val Ala Lys Pro 
        195                 200                 205             


Ser Glu Glu Glu Gln Lys Glu Leu Asp Glu Ile Thr Ala Lys Arg Gln 
    210                 215                 220                 


Lys Lys Gly Lys Gln Glu Glu Glu Lys Pro Gly Glu Glu Lys Thr Ile 
225                 230                 235                 240 


Leu His Val Lys Glu Met Tyr Asp Tyr Gln Gly Arg Ser Tyr Leu His 
                245                 250                 255     


Ile Pro Gln Asp Val Gly Val Asn Leu Arg Ser Thr Met Pro Pro Glu 
            260                 265                 270         


Lys Cys Tyr Leu Pro Lys Lys Gln Ile His Val Trp Ser Gly His Thr 
        275                 280                 285             


Lys Gly Val Ser Ala Val Arg Leu Phe Pro Leu Ser Gly His Leu Leu 
    290                 295                 300                 


Leu Ser Cys Ser Met Asp Cys Lys Ile Lys Leu Trp Glu Val Tyr Gly 
305                 310                 315                 320 


Glu Arg Arg Cys Leu Arg Thr Phe Ile Gly His Ser Lys Ala Val Arg 
                325                 330                 335     


Asp Ile Cys Phe Asn Thr Ala Gly Thr Gln Phe Leu Ser Ala Ala Tyr 
            340                 345                 350         


Asp Arg Tyr Leu Lys Leu Trp Asp Thr Glu Thr Gly Gln Cys Ile Ser 
        355                 360                 365             


Arg Phe Thr Asn Arg Lys Val Pro Tyr Cys Val Lys Phe Asn Pro Asp 
    370                 375                 380                 


Glu Asp Lys Gln Asn Leu Phe Val Ala Gly Met Ser Asp Lys Lys Ile 
385                 390                 395                 400 


Val Gln Trp Asp Ile Arg Ser Gly Glu Ile Val Gln Glu Tyr Asp Arg 
                405                 410                 415     


His Leu Gly Ala Val Asn Thr Ile Val Phe Val Asp Glu Asn Arg Arg 
            420                 425                 430         


Phe Val Ser Thr Ser Asp Asp Lys Ser Leu Arg Val Trp Glu Trp Asp 
        435                 440                 445             


Ile Pro Val Asp Phe Lys Tyr Ile Ala Glu Pro Ser Met His Ser Met 
    450                 455                 460                 


Pro Ala Val Thr Leu Ser Pro Asn Gly Lys Trp Leu Ala Cys Gln Ser 
465                 470                 475                 480 


Met Asp Asn Gln Ile Leu Ile Phe Gly Ala Gln Asn Arg Phe Arg Leu 
                485                 490                 495     


Asn Lys Lys Lys Ile Phe Lys Gly His Met Val Ala Gly Tyr Ala Cys 
            500                 505                 510         


Gln Val Asp Phe Ser Pro Asp Met Ser Tyr Val Ile Ser Gly Asp Gly 
        515                 520                 525             


Asn Gly Lys Leu Asn Ile Trp Asp Trp Lys Thr Thr Lys Leu Tyr Ser 
    530                 535                 540                 


Arg Phe Lys Ala His Asp Lys Val Cys Ile Gly Ala Val Trp His Pro 
545                 550                 555                 560 


His Glu Thr Ser Lys Val Ile Thr Cys Gly Trp Asp Gly Leu Ile Lys 
                565                 570                 575     


Leu Trp Asp 
            


<210>  2451
<211>  539
<212>  PRT
<213>  Homo Sapiens

<400>  2451

Met Ser Ala Ala Ile Ala Ala Leu Ala Ala Ser Tyr Gly Ser Gly Ser 
1               5                   10                  15      


Gly Ser Glu Ser Asp Ser Asp Ser Glu Ser Ser Arg Cys Pro Leu Pro 
            20                  25                  30          


Ala Ala Asp Ser Leu Met His Leu Thr Lys Ser Pro Ser Ser Lys Pro 
        35                  40                  45              


Ser Leu Ala Val Ala Val Asp Ser Ala Pro Glu Val Ala Val Lys Glu 
    50                  55                  60                  


Asp Leu Glu Thr Gly Val His Leu Asp Pro Ala Val Lys Glu Val Gln 
65                  70                  75                  80  


Tyr Asn Pro Thr Tyr Glu Thr Met Phe Ala Pro Glu Phe Gly Pro Glu 
                85                  90                  95      


Asn Pro Phe Arg Thr Gln Gln Met Ala Ala Pro Arg Asn Met Leu Ser 
            100                 105                 110         


Gly Tyr Ala Glu Pro Ala His Ile Asn Asp Phe Met Phe Glu Gln Gln 
        115                 120                 125             


Arg Arg Thr Phe Ala Thr Tyr Gly Tyr Ala Leu Asp Pro Ser Leu Asp 
    130                 135                 140                 


Asn His Gln Val Ser Ala Lys Tyr Ile Gly Ser Val Glu Glu Ala Glu 
145                 150                 155                 160 


Lys Asn Gln Gly Leu Thr Val Phe Glu Thr Gly Gln Lys Lys Thr Glu 
                165                 170                 175     


Lys Arg Lys Lys Phe Lys Glu Asn Asp Ala Ser Asn Ile Asp Gly Phe 
            180                 185                 190         


Leu Gly Pro Trp Ala Lys Tyr Val Asp Glu Lys Asp Val Ala Lys Pro 
        195                 200                 205             


Ser Glu Glu Glu Gln Lys Glu Leu Asp Glu Ile Thr Ala Lys Arg Gln 
    210                 215                 220                 


Lys Lys Gly Lys Gln Glu Glu Glu Lys Pro Gly Glu Glu Lys Thr Ile 
225                 230                 235                 240 


Leu His Val Lys Glu Met Tyr Asp Tyr Gln Gly Arg Ser Tyr Leu His 
                245                 250                 255     


Ile Pro Gln Asp Val Gly Val Asn Leu Arg Ser Thr Met Pro Pro Glu 
            260                 265                 270         


Lys Cys Tyr Leu Pro Lys Lys Gln Ile His Val Trp Ser Gly His Thr 
        275                 280                 285             


Lys Gly Val Ser Ala Val Arg Leu Phe Pro Leu Ser Gly His Leu Leu 
    290                 295                 300                 


Leu Ser Cys Ser Met Asp Cys Lys Ile Lys Leu Trp Glu Val Tyr Gly 
305                 310                 315                 320 


Glu Arg Arg Cys Leu Arg Thr Phe Ile Gly His Ser Lys Ala Val Arg 
                325                 330                 335     


Asp Ile Cys Phe Asn Thr Ala Gly Thr Gln Phe Leu Ser Ala Ala Tyr 
            340                 345                 350         


Asp Arg Tyr Leu Lys Leu Trp Asp Thr Glu Thr Gly Gln Cys Ile Ser 
        355                 360                 365             


Arg Phe Thr Asn Arg Lys Val Pro Tyr Cys Val Lys Phe Asn Pro Asp 
    370                 375                 380                 


Glu Asp Lys Gln Asn Leu Phe Val Ala Gly Met Ser Asp Lys Lys Ile 
385                 390                 395                 400 


Val Gln Trp Asp Ile Arg Ser Gly Glu Ile Val Gln Glu Tyr Asp Arg 
                405                 410                 415     


His Leu Gly Ala Val Asn Thr Ile Val Phe Val Asp Glu Asn Arg Arg 
            420                 425                 430         


Phe Val Ser Thr Ser Asp Asp Lys Ser Leu Arg Val Trp Glu Trp Asp 
        435                 440                 445             


Ile Pro Val Asp Phe Lys Tyr Ile Ala Glu Pro Ser Met His Ser Met 
    450                 455                 460                 


Pro Ala Val Thr Leu Ser Pro Asn Gly Lys Trp Leu Ala Cys Gln Ser 
465                 470                 475                 480 


Met Asp Asn Gln Ile Leu Ile Phe Gly Ala Gln Asn Arg Phe Arg Leu 
                485                 490                 495     


Asn Lys Lys Lys Ile Phe Lys Gly His Met Val Ala Gly Tyr Ala Cys 
            500                 505                 510         


Gln Val Asp Phe Ser Pro Asp Met Arg Val Pro Gln Ser Phe Gln Asn 
        515                 520                 525             


Leu Lys Glu Val Thr Ala Gly Pro Gln Glu Gly 
    530                 535                 


<210>  2452
<211>  579
<212>  PRT
<213>  Homo Sapiens

<400>  2452

Met Ser Ala Ala Ile Ala Ala Leu Ala Ala Ser Tyr Gly Ser Gly Ser 
1               5                   10                  15      


Gly Ser Glu Ser Asp Ser Asp Ser Glu Ser Ser Arg Cys Pro Leu Pro 
            20                  25                  30          


Ala Ala Asp Ser Leu Met His Leu Thr Lys Ser Pro Ser Ser Lys Pro 
        35                  40                  45              


Ser Leu Ala Val Ala Val Asp Ser Ala Pro Glu Val Ala Val Lys Glu 
    50                  55                  60                  


Asp Leu Glu Thr Gly Val His Leu Asp Pro Ala Val Lys Glu Val Gln 
65                  70                  75                  80  


Tyr Asn Pro Thr Tyr Glu Thr Met Phe Ala Pro Glu Phe Gly Pro Glu 
                85                  90                  95      


Asn Pro Phe Arg Thr Gln Gln Met Ala Ala Pro Arg Asn Met Leu Ser 
            100                 105                 110         


Gly Tyr Ala Glu Pro Ala His Ile Asn Asp Phe Met Phe Glu Gln Gln 
        115                 120                 125             


Arg Arg Thr Phe Ala Thr Tyr Gly Tyr Ala Leu Asp Pro Ser Leu Asp 
    130                 135                 140                 


Asn His Gln Val Ser Ala Lys Tyr Ile Gly Ser Val Glu Glu Ala Glu 
145                 150                 155                 160 


Lys Asn Gln Gly Leu Thr Val Phe Glu Thr Gly Gln Lys Lys Thr Glu 
                165                 170                 175     


Lys Arg Lys Lys Phe Lys Glu Asn Asp Ala Ser Asn Ile Asp Gly Phe 
            180                 185                 190         


Leu Gly Pro Trp Ala Lys Tyr Val Asp Glu Lys Asp Val Ala Lys Pro 
        195                 200                 205             


Ser Glu Glu Glu Gln Lys Glu Leu Asp Glu Ile Thr Ala Lys Arg Gln 
    210                 215                 220                 


Lys Lys Gly Lys Gln Glu Glu Glu Lys Pro Gly Glu Glu Lys Thr Ile 
225                 230                 235                 240 


Leu His Val Lys Glu Met Tyr Asp Tyr Gln Gly Arg Ser Tyr Leu His 
                245                 250                 255     


Ile Pro Gln Asp Val Gly Val Asn Leu Arg Ser Thr Met Pro Pro Glu 
            260                 265                 270         


Lys Cys Tyr Leu Pro Lys Lys Gln Ile His Val Trp Ser Gly His Thr 
        275                 280                 285             


Lys Gly Val Ser Ala Val Arg Leu Phe Pro Leu Ser Gly His Leu Leu 
    290                 295                 300                 


Leu Ser Cys Ser Met Asp Cys Lys Ile Lys Leu Trp Glu Val Tyr Gly 
305                 310                 315                 320 


Glu Arg Arg Cys Leu Arg Thr Phe Ile Gly His Ser Lys Ala Val Arg 
                325                 330                 335     


Asp Ile Cys Phe Asn Thr Ala Gly Thr Gln Phe Leu Ser Ala Ala Tyr 
            340                 345                 350         


Asp Arg Tyr Leu Lys Leu Trp Asp Thr Glu Thr Gly Gln Cys Ile Ser 
        355                 360                 365             


Arg Phe Thr Asn Arg Lys Val Pro Tyr Cys Val Lys Phe Asn Pro Asp 
    370                 375                 380                 


Glu Asp Lys Gln Asn Leu Phe Val Ala Gly Met Ser Asp Lys Lys Ile 
385                 390                 395                 400 


Val Gln Trp Asp Ile Arg Ser Gly Glu Ile Val Gln Glu Tyr Asp Arg 
                405                 410                 415     


His Leu Gly Ala Val Asn Thr Ile Val Phe Val Asp Glu Asn Arg Arg 
            420                 425                 430         


Phe Val Ser Thr Ser Asp Asp Lys Ser Leu Arg Val Trp Glu Trp Asp 
        435                 440                 445             


Ile Pro Val Asp Phe Lys Tyr Ile Ala Glu Pro Ser Met His Ser Met 
    450                 455                 460                 


Pro Ala Val Thr Leu Ser Pro Asn Gly Lys Trp Leu Ala Cys Gln Ser 
465                 470                 475                 480 


Met Asp Asn Gln Ile Leu Ile Phe Gly Ala Gln Asn Arg Phe Arg Leu 
                485                 490                 495     


Asn Lys Lys Lys Ile Phe Lys Gly His Met Val Ala Gly Tyr Ala Cys 
            500                 505                 510         


Gln Val Asp Phe Ser Pro Asp Met Ser Tyr Val Ile Ser Gly Asp Gly 
        515                 520                 525             


Asn Gly Lys Leu Asn Ile Trp Asp Trp Lys Thr Thr Lys Leu Tyr Ser 
    530                 535                 540                 


Arg Phe Lys Ala His Asp Lys Val Cys Ile Gly Ala Val Trp His Pro 
545                 550                 555                 560 


His Glu Thr Ser Lys Val Ile Thr Cys Gly Trp Asp Gly Leu Ile Lys 
                565                 570                 575     


Leu Trp Asp 
            


<210>  2453
<211>  112
<212>  PRT
<213>  Homo Sapiens

<400>  2453

Met Phe Val Ser Asp Phe Arg Lys Glu Phe Tyr Glu Val Val Gln Ser 
1               5                   10                  15      


Gln Arg Val Leu Leu Phe Val Ala Ser Asp Val Asp Ala Leu Cys Ala 
            20                  25                  30          


Cys Lys Ile Leu Gln Ala Leu Phe Gln Cys Asp His Val Gln Tyr Thr 
        35                  40                  45              


Leu Val Pro Val Ser Gly Trp Gln Glu Leu Glu Thr Ala Phe Leu Glu 
    50                  55                  60                  


His Lys Glu Gln Phe His Tyr Phe Ile Leu Ile Asn Cys Gly Ala Asn 
65                  70                  75                  80  


Val Asp Leu Leu Asp Ile Leu Gln Pro Asp Glu Asp Thr Ile Phe Phe 
                85                  90                  95      


Val Cys Asp Thr His Arg Pro Val Asn Val Val Asn Val Tyr Asn Asp 
            100                 105                 110         


<210>  2454
<211>  566
<212>  PRT
<213>  Homo Sapiens

<400>  2454

Met Phe Val Ser Asp Phe Arg Lys Glu Phe Tyr Glu Val Val Gln Ser 
1               5                   10                  15      


Gln Arg Val Leu Leu Phe Val Ala Ser Asp Val Asp Ala Leu Cys Ala 
            20                  25                  30          


Cys Lys Ile Leu Gln Ala Leu Phe Gln Cys Asp His Val Gln Tyr Thr 
        35                  40                  45              


Leu Val Pro Val Ser Gly Trp Gln Glu Leu Glu Thr Ala Phe Leu Glu 
    50                  55                  60                  


His Lys Glu Gln Phe His Tyr Phe Ile Leu Ile Asn Cys Gly Ala Asn 
65                  70                  75                  80  


Val Asp Leu Leu Asp Ile Leu Gln Pro Asp Glu Asp Thr Ile Phe Phe 
                85                  90                  95      


Val Cys Asp Thr His Arg Pro Val Asn Val Val Asn Val Tyr Asn Asp 
            100                 105                 110         


Thr Gln Ile Lys Leu Leu Ile Lys Gln Asp Asp Asp Leu Glu Val Pro 
        115                 120                 125             


Ala Tyr Glu Asp Ile Phe Arg Asp Glu Glu Glu Asp Glu Glu His Ser 
    130                 135                 140                 


Gly Asn Asp Ser Asp Gly Ser Glu Pro Ser Glu Lys Arg Thr Arg Leu 
145                 150                 155                 160 


Glu Glu Glu Ile Val Glu Gln Thr Met Arg Arg Arg Gln Arg Arg Glu 
                165                 170                 175     


Trp Glu Ala Arg Arg Arg Asp Ile Leu Phe Asp Tyr Glu Gln Tyr Glu 
            180                 185                 190         


Tyr His Gly Thr Ser Ser Ala Met Val Met Phe Glu Leu Ala Trp Met 
        195                 200                 205             


Leu Ser Lys Asp Leu Asn Asp Met Leu Trp Trp Ala Ile Val Gly Leu 
    210                 215                 220                 


Thr Asp Gln Trp Val Gln Asp Lys Ile Thr Gln Met Lys Tyr Val Thr 
225                 230                 235                 240 


Asp Val Gly Val Leu Gln Arg His Val Ser Arg His Asn His Arg Asn 
                245                 250                 255     


Glu Asp Glu Glu Asn Thr Leu Ser Val Asp Cys Thr Arg Ile Ser Phe 
            260                 265                 270         


Glu Tyr Asp Leu Arg Leu Val Leu Tyr Gln His Trp Ser Leu His Asp 
        275                 280                 285             


Ser Leu Cys Asn Thr Ser Tyr Thr Ala Ala Arg Phe Lys Leu Trp Ser 
    290                 295                 300                 


Val His Gly Gln Lys Arg Leu Gln Glu Phe Leu Ala Asp Met Gly Leu 
305                 310                 315                 320 


Pro Leu Lys Gln Val Lys Gln Lys Phe Gln Ala Met Asp Ile Ser Leu 
                325                 330                 335     


Lys Glu Asn Leu Arg Glu Met Ile Glu Glu Ser Ala Asn Lys Phe Gly 
            340                 345                 350         


Met Lys Asp Met Arg Val Gln Thr Phe Ser Ile His Phe Gly Phe Lys 
        355                 360                 365             


His Lys Phe Leu Ala Ser Asp Val Val Phe Ala Thr Met Ser Leu Met 
    370                 375                 380                 


Glu Ser Pro Glu Lys Asp Gly Ser Gly Thr Asp His Phe Ile Gln Ala 
385                 390                 395                 400 


Leu Asp Ser Leu Ser Arg Ser Asn Leu Asp Lys Leu Tyr His Gly Leu 
                405                 410                 415     


Glu Leu Ala Lys Lys Gln Leu Arg Ala Thr Gln Gln Thr Ile Ala Ser 
            420                 425                 430         


Cys Leu Cys Thr Asn Leu Val Ile Ser Gln Gly Pro Phe Leu Tyr Cys 
        435                 440                 445             


Ser Leu Met Glu Gly Thr Pro Asp Val Met Leu Phe Ser Arg Pro Ala 
    450                 455                 460                 


Ser Leu Ser Leu Leu Ser Lys His Leu Leu Lys Ser Phe Val Cys Ser 
465                 470                 475                 480 


Thr Lys Asn Arg Arg Cys Lys Leu Leu Pro Leu Val Met Ala Ala Pro 
                485                 490                 495     


Leu Ser Met Glu His Gly Thr Val Thr Val Val Gly Ile Pro Pro Glu 
            500                 505                 510         


Thr Asp Ser Ser Asp Arg Lys Asn Phe Phe Gly Arg Ala Phe Glu Lys 
        515                 520                 525             


Ala Ala Glu Ser Thr Ser Ser Arg Met Leu His Asn His Phe Asp Leu 
    530                 535                 540                 


Ser Val Ile Glu Leu Lys Ala Glu Asp Arg Ser Lys Phe Leu Asp Ala 
545                 550                 555                 560 


Leu Ile Ser Leu Leu Ser 
                565     


<210>  2455
<211>  566
<212>  PRT
<213>  Homo Sapiens

<400>  2455

Met Phe Val Ser Asp Phe Arg Lys Glu Phe Tyr Glu Val Val Gln Ser 
1               5                   10                  15      


Gln Arg Val Leu Leu Phe Val Ala Ser Asp Val Asp Ala Leu Cys Ala 
            20                  25                  30          


Cys Lys Ile Leu Gln Ala Leu Phe Gln Cys Asp His Val Gln Tyr Thr 
        35                  40                  45              


Leu Val Pro Val Ser Gly Trp Gln Glu Leu Glu Thr Ala Phe Leu Glu 
    50                  55                  60                  


His Lys Glu Gln Phe His Tyr Phe Ile Leu Ile Asn Cys Gly Ala Asn 
65                  70                  75                  80  


Val Asp Leu Leu Asp Ile Leu Gln Pro Asp Glu Asp Thr Ile Phe Phe 
                85                  90                  95      


Val Cys Asp Thr His Arg Pro Val Asn Val Val Asn Val Tyr Asn Asp 
            100                 105                 110         


Thr Gln Ile Lys Leu Leu Ile Lys Gln Asp Asp Asp Leu Glu Val Pro 
        115                 120                 125             


Ala Tyr Glu Asp Ile Phe Arg Asp Glu Glu Glu Asp Glu Glu His Ser 
    130                 135                 140                 


Gly Asn Asp Ser Asp Gly Ser Glu Pro Ser Glu Lys Arg Thr Arg Leu 
145                 150                 155                 160 


Glu Glu Glu Ile Val Glu Gln Thr Met Arg Arg Arg Gln Arg Arg Glu 
                165                 170                 175     


Trp Glu Ala Arg Arg Arg Asp Ile Leu Phe Asp Tyr Glu Gln Tyr Glu 
            180                 185                 190         


Tyr His Gly Thr Ser Ser Ala Met Val Met Phe Glu Leu Ala Trp Met 
        195                 200                 205             


Leu Ser Lys Asp Leu Asn Asp Met Leu Trp Trp Ala Ile Val Gly Leu 
    210                 215                 220                 


Thr Asp Gln Trp Val Gln Asp Lys Ile Thr Gln Met Lys Tyr Val Thr 
225                 230                 235                 240 


Asp Val Gly Val Leu Gln Arg His Val Ser Arg His Asn His Arg Asn 
                245                 250                 255     


Glu Asp Glu Glu Asn Thr Leu Ser Val Asp Cys Thr Arg Ile Ser Phe 
            260                 265                 270         


Glu Tyr Asp Leu Arg Leu Val Leu Tyr Gln His Trp Ser Leu His Asp 
        275                 280                 285             


Ser Leu Cys Asn Thr Ser Tyr Thr Ala Ala Arg Phe Lys Leu Trp Ser 
    290                 295                 300                 


Val His Gly Gln Lys Arg Leu Gln Glu Phe Leu Ala Asp Met Gly Leu 
305                 310                 315                 320 


Pro Leu Lys Gln Val Lys Gln Lys Phe Gln Ala Met Asp Ile Ser Leu 
                325                 330                 335     


Lys Glu Asn Leu Arg Glu Met Ile Glu Glu Ser Ala Asn Lys Phe Gly 
            340                 345                 350         


Met Lys Asp Met Arg Val Gln Thr Phe Ser Ile His Phe Gly Phe Lys 
        355                 360                 365             


His Lys Phe Leu Ala Ser Asp Val Val Phe Ala Thr Met Ser Leu Met 
    370                 375                 380                 


Glu Ser Pro Glu Lys Asp Gly Ser Gly Thr Asp His Phe Ile Gln Ala 
385                 390                 395                 400 


Leu Asp Ser Leu Ser Arg Ser Asn Leu Asp Lys Leu Tyr His Gly Leu 
                405                 410                 415     


Glu Leu Ala Lys Lys Gln Leu Arg Ala Thr Gln Gln Thr Ile Ala Ser 
            420                 425                 430         


Cys Leu Cys Thr Asn Leu Val Ile Ser Gln Gly Pro Phe Leu Tyr Cys 
        435                 440                 445             


Ser Leu Met Glu Gly Thr Pro Asp Val Met Leu Phe Ser Arg Pro Ala 
    450                 455                 460                 


Ser Leu Ser Leu Leu Ser Lys His Leu Leu Lys Ser Phe Val Cys Ser 
465                 470                 475                 480 


Thr Lys Asn Arg Arg Cys Lys Leu Leu Pro Leu Val Met Ala Ala Pro 
                485                 490                 495     


Leu Ser Met Glu His Gly Thr Val Thr Val Val Gly Ile Pro Pro Glu 
            500                 505                 510         


Thr Asp Ser Ser Asp Arg Lys Asn Phe Phe Gly Arg Ala Phe Glu Lys 
        515                 520                 525             


Ala Ala Glu Ser Thr Ser Ser Arg Met Leu His Asn His Phe Asp Leu 
    530                 535                 540                 


Ser Val Ile Glu Leu Lys Ala Glu Asp Arg Ser Lys Phe Leu Asp Ala 
545                 550                 555                 560 


Leu Ile Ser Leu Leu Ser 
                565     


<210>  2456
<211>  598
<212>  PRT
<213>  Homo Sapiens

<400>  2456

Met Phe Val Ser Asp Phe Arg Lys Glu Phe Tyr Glu Val Val Gln Ser 
1               5                   10                  15      


Gln Arg Val Leu Leu Phe Val Ala Ser Asp Val Asp Ala Leu Cys Ala 
            20                  25                  30          


Cys Lys Ile Leu Gln Ala Leu Phe Gln Cys Asp His Val Gln Tyr Thr 
        35                  40                  45              


Leu Val Pro Val Ser Gly Trp Gln Glu Leu Glu Thr Ala Phe Leu Glu 
    50                  55                  60                  


His Lys Glu Gln Phe His Tyr Phe Ile Leu Ile Asn Cys Gly Ala Asn 
65                  70                  75                  80  


Val Asp Leu Leu Asp Ile Leu Gln Pro Asp Glu Asp Thr Ile Phe Phe 
                85                  90                  95      


Val Cys Asp Thr His Arg Pro Val Asn Val Val Asn Val Tyr Asn Asp 
            100                 105                 110         


Thr Gln Ile Lys Leu Leu Ile Lys Gln Asp Asp Asp Leu Glu Val Pro 
        115                 120                 125             


Ala Tyr Glu Asp Ile Phe Arg Asp Glu Glu Glu Asp Glu Glu His Ser 
    130                 135                 140                 


Gly Asn Asp Ser Asp Gly Ser Glu Pro Ser Glu Lys Arg Thr Arg Leu 
145                 150                 155                 160 


Glu Glu Glu Ile Val Glu Gln Thr Met Arg Arg Arg Gln Arg Arg Glu 
                165                 170                 175     


Trp Glu Ala Arg Ser Gly Ser Gly Ser Glu Pro Val Ala Ala Ala Leu 
            180                 185                 190         


Glu Lys Ser Ser Arg Leu Phe Ala Gly Pro Met Ser Asp Arg Thr Ala 
        195                 200                 205             


Pro Arg Ser Pro Arg Arg Asp Ile Leu Phe Asp Tyr Glu Gln Tyr Glu 
    210                 215                 220                 


Tyr His Gly Thr Ser Ser Ala Met Val Met Phe Glu Leu Ala Trp Met 
225                 230                 235                 240 


Leu Ser Lys Asp Leu Asn Asp Met Leu Trp Trp Ala Ile Val Gly Leu 
                245                 250                 255     


Thr Asp Gln Trp Val Gln Asp Lys Ile Thr Gln Met Lys Tyr Val Thr 
            260                 265                 270         


Asp Val Gly Val Leu Gln Arg His Val Ser Arg His Asn His Arg Asn 
        275                 280                 285             


Glu Asp Glu Glu Asn Thr Leu Ser Val Asp Cys Thr Arg Ile Ser Phe 
    290                 295                 300                 


Glu Tyr Asp Leu Arg Leu Val Leu Tyr Gln His Trp Ser Leu His Asp 
305                 310                 315                 320 


Ser Leu Cys Asn Thr Ser Tyr Thr Ala Ala Arg Phe Lys Leu Trp Ser 
                325                 330                 335     


Val His Gly Gln Lys Arg Leu Gln Glu Phe Leu Ala Asp Met Gly Leu 
            340                 345                 350         


Pro Leu Lys Gln Val Lys Gln Lys Phe Gln Ala Met Asp Ile Ser Leu 
        355                 360                 365             


Lys Glu Asn Leu Arg Glu Met Ile Glu Glu Ser Ala Asn Lys Phe Gly 
    370                 375                 380                 


Met Lys Asp Met Arg Val Gln Thr Phe Ser Ile His Phe Gly Phe Lys 
385                 390                 395                 400 


His Lys Phe Leu Ala Ser Asp Val Val Phe Ala Thr Met Ser Leu Met 
                405                 410                 415     


Glu Ser Pro Glu Lys Asp Gly Ser Gly Thr Asp His Phe Ile Gln Ala 
            420                 425                 430         


Leu Asp Ser Leu Ser Arg Ser Asn Leu Asp Lys Leu Tyr His Gly Leu 
        435                 440                 445             


Glu Leu Ala Lys Lys Gln Leu Arg Ala Thr Gln Gln Thr Ile Ala Ser 
    450                 455                 460                 


Cys Leu Cys Thr Asn Leu Val Ile Ser Gln Gly Pro Phe Leu Tyr Cys 
465                 470                 475                 480 


Ser Leu Met Glu Gly Thr Pro Asp Val Met Leu Phe Ser Arg Pro Ala 
                485                 490                 495     


Ser Leu Ser Leu Leu Ser Lys His Leu Leu Lys Ser Phe Val Cys Ser 
            500                 505                 510         


Thr Lys Asn Arg Arg Cys Lys Leu Leu Pro Leu Val Met Ala Ala Pro 
        515                 520                 525             


Leu Ser Met Glu His Gly Thr Val Thr Val Val Gly Ile Pro Pro Glu 
    530                 535                 540                 


Thr Asp Ser Ser Asp Arg Lys Asn Phe Phe Gly Arg Ala Phe Glu Lys 
545                 550                 555                 560 


Ala Ala Glu Ser Thr Ser Ser Arg Met Leu His Asn His Phe Asp Leu 
                565                 570                 575     


Ser Val Ile Glu Leu Lys Ala Glu Asp Arg Ser Lys Phe Leu Asp Ala 
            580                 585                 590         


Leu Ile Ser Leu Leu Ser 
        595             


<210>  2457
<211>  520
<212>  PRT
<213>  Homo Sapiens

<400>  2457

Met Phe Val Ser Asp Phe Arg Lys Glu Phe Tyr Glu Val Val Gln Ser 
1               5                   10                  15      


Gln Arg Val Leu Leu Phe Val Ala Ser Asp Val Asp Ala Leu Cys Ala 
            20                  25                  30          


Cys Lys Ile Leu Gln Ala Leu Phe Gln Cys Asp His Val Gln Tyr Thr 
        35                  40                  45              


Leu Val Pro Val Ser Gly Trp Gln Glu Leu Glu Thr Ala Phe Leu Glu 
    50                  55                  60                  


His Lys Glu Gln Ile Lys Leu Leu Ile Lys Gln Asp Asp Asp Leu Glu 
65                  70                  75                  80  


Val Pro Ala Tyr Glu Asp Ile Phe Arg Asp Glu Glu Glu Asp Glu Glu 
                85                  90                  95      


His Ser Gly Asn Asp Ser Asp Gly Ser Glu Pro Ser Glu Lys Arg Thr 
            100                 105                 110         


Arg Leu Glu Glu Glu Ile Val Glu Gln Thr Met Arg Arg Arg Gln Arg 
        115                 120                 125             


Arg Glu Trp Glu Ala Arg Arg Arg Asp Ile Leu Phe Asp Tyr Glu Gln 
    130                 135                 140                 


Tyr Glu Tyr His Gly Thr Ser Ser Ala Met Val Met Phe Glu Leu Ala 
145                 150                 155                 160 


Trp Met Leu Ser Lys Asp Leu Asn Asp Met Leu Trp Trp Ala Ile Val 
                165                 170                 175     


Gly Leu Thr Asp Gln Trp Val Gln Asp Lys Ile Thr Gln Met Lys Tyr 
            180                 185                 190         


Val Thr Asp Val Gly Val Leu Gln Arg His Val Ser Arg His Asn His 
        195                 200                 205             


Arg Asn Glu Asp Glu Glu Asn Thr Leu Ser Val Asp Cys Thr Arg Ile 
    210                 215                 220                 


Ser Phe Glu Tyr Asp Leu Arg Leu Val Leu Tyr Gln His Trp Ser Leu 
225                 230                 235                 240 


His Asp Ser Leu Cys Asn Thr Ser Tyr Thr Ala Ala Arg Phe Lys Leu 
                245                 250                 255     


Trp Ser Val His Gly Gln Lys Arg Leu Gln Glu Phe Leu Ala Asp Met 
            260                 265                 270         


Gly Leu Pro Leu Lys Gln Val Lys Gln Lys Phe Gln Ala Met Asp Ile 
        275                 280                 285             


Ser Leu Lys Glu Asn Leu Arg Glu Met Ile Glu Glu Ser Ala Asn Lys 
    290                 295                 300                 


Phe Gly Met Lys Asp Met Arg Val Gln Thr Phe Ser Ile His Phe Gly 
305                 310                 315                 320 


Phe Lys His Lys Phe Leu Ala Ser Asp Val Val Phe Ala Thr Met Ser 
                325                 330                 335     


Leu Met Glu Ser Pro Glu Lys Asp Gly Ser Gly Thr Asp His Phe Ile 
            340                 345                 350         


Gln Ala Leu Asp Ser Leu Ser Arg Ser Asn Leu Asp Lys Leu Tyr His 
        355                 360                 365             


Gly Leu Glu Leu Ala Lys Lys Gln Leu Arg Ala Thr Gln Gln Thr Ile 
    370                 375                 380                 


Ala Ser Cys Leu Cys Thr Asn Leu Val Ile Ser Gln Gly Pro Phe Leu 
385                 390                 395                 400 


Tyr Cys Ser Leu Met Glu Gly Thr Pro Asp Val Met Leu Phe Ser Arg 
                405                 410                 415     


Pro Ala Ser Leu Ser Leu Leu Ser Lys His Leu Leu Lys Ser Phe Val 
            420                 425                 430         


Cys Ser Thr Lys Asn Arg Arg Cys Lys Leu Leu Pro Leu Val Met Ala 
        435                 440                 445             


Ala Pro Leu Ser Met Glu His Gly Thr Val Thr Val Val Gly Ile Pro 
    450                 455                 460                 


Pro Glu Thr Asp Ser Ser Asp Arg Lys Asn Phe Phe Gly Arg Ala Phe 
465                 470                 475                 480 


Glu Lys Ala Ala Glu Ser Thr Ser Ser Arg Met Leu His Asn His Phe 
                485                 490                 495     


Asp Leu Ser Val Ile Glu Leu Lys Ala Glu Asp Arg Ser Lys Phe Leu 
            500                 505                 510         


Asp Ala Leu Ile Ser Leu Leu Ser 
        515                 520 


<210>  2458
<211>  159
<212>  PRT
<213>  Homo Sapiens

<400>  2458

Met Leu Pro His Trp Arg Val Leu Leu Phe Val Ala Ser Asp Val Asp 
1               5                   10                  15      


Ala Leu Cys Ala Cys Lys Ile Leu Gln Ala Leu Phe Gln Cys Asp His 
            20                  25                  30          


Val Gln Tyr Thr Leu Val Pro Val Ser Gly Trp Gln Glu Leu Glu Thr 
        35                  40                  45              


Ala Phe Leu Glu His Lys Glu Gln Phe His Tyr Phe Ile Leu Ile Asn 
    50                  55                  60                  


Cys Gly Ala Asn Val Asp Leu Leu Asp Ile Leu Gln Pro Asp Glu Asp 
65                  70                  75                  80  


Thr Ile Phe Phe Val Cys Asp Thr His Arg Pro Val Asn Val Val Asn 
                85                  90                  95      


Val Tyr Asn Asp Thr Gln Ile Lys Leu Leu Ile Lys Gln Asp Asp Asp 
            100                 105                 110         


Leu Glu Val Pro Ala Tyr Glu Asp Ile Phe Arg Asp Glu Glu Glu Asp 
        115                 120                 125             


Glu Glu His Ser Gly Asn Asp Ser Asp Gly Ser Glu Pro Ser Glu Lys 
    130                 135                 140                 


Arg Thr Arg Leu Glu Glu Glu Ile Val Glu Gln Thr Met Arg Arg 
145                 150                 155                 


<210>  2459
<211>  96
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2459

Xaa Asp Glu Asp Thr Ile Phe Phe Val Cys Asp Thr His Arg Pro Val 
1               5                   10                  15      


Asn Val Val Asn Val Tyr Asn Asp Thr Gln Ile Lys Leu Leu Ile Lys 
            20                  25                  30          


Gln Asp Asp Asp Leu Glu Val Pro Ala Tyr Glu Asp Ile Phe Arg Asp 
        35                  40                  45              


Glu Glu Glu Asp Glu Glu His Ser Gly Asn Asp Ser Asp Gly Ser Glu 
    50                  55                  60                  


Pro Ser Glu Lys Arg Thr Arg Leu Glu Glu Glu Ile Val Glu Gln Thr 
65                  70                  75                  80  


Met Arg Arg Arg Gln Arg Arg Glu Trp Glu Ala Arg Arg Ile Ile Tyr 
                85                  90                  95      


<210>  2460
<211>  836
<212>  PRT
<213>  Homo Sapiens

<400>  2460

Met Ala Gly Leu Asn Cys Gly Val Ser Ile Ala Leu Leu Gly Val Leu 
1               5                   10                  15      


Leu Leu Gly Ala Ala Arg Leu Pro Arg Gly Ala Glu Ala Phe Glu Ile 
            20                  25                  30          


Ala Leu Pro Arg Glu Ser Asn Ile Thr Val Leu Ile Lys Leu Gly Thr 
        35                  40                  45              


Pro Thr Leu Leu Ala Lys Pro Cys Tyr Ile Val Ile Ser Lys Arg His 
    50                  55                  60                  


Ile Thr Met Leu Ser Ile Lys Ser Gly Glu Arg Ile Val Phe Thr Phe 
65                  70                  75                  80  


Ser Cys Gln Ser Pro Glu Asn His Phe Val Ile Glu Ile Gln Lys Asn 
                85                  90                  95      


Ile Asp Cys Met Ser Gly Pro Cys Pro Phe Gly Glu Val Gln Leu Gln 
            100                 105                 110         


Pro Ser Thr Ser Leu Leu Pro Thr Leu Asn Arg Thr Phe Ile Trp Asp 
        115                 120                 125             


Val Lys Ala His Lys Ser Ile Gly Leu Glu Leu Gln Phe Ser Ile Pro 
    130                 135                 140                 


Arg Leu Arg Gln Ile Gly Pro Gly Glu Ser Cys Pro Asp Gly Val Thr 
145                 150                 155                 160 


His Ser Ile Ser Gly Arg Ile Asp Ala Thr Val Val Arg Ile Gly Thr 
                165                 170                 175     


Phe Cys Ser Asn Gly Thr Val Ser Arg Ile Lys Met Gln Glu Gly Val 
            180                 185                 190         


Lys Met Ala Leu His Leu Pro Trp Phe His Pro Arg Asn Val Ser Gly 
        195                 200                 205             


Phe Ser Ile Ala Asn Arg Ser Ser Ile Lys Arg Leu Cys Ile Ile Glu 
    210                 215                 220                 


Ser Val Phe Glu Gly Glu Gly Ser Ala Thr Leu Met Ser Ala Asn Tyr 
225                 230                 235                 240 


Pro Glu Gly Phe Pro Glu Asp Glu Leu Met Thr Trp Gln Phe Val Val 
                245                 250                 255     


Pro Ala His Leu Arg Ala Ser Val Ser Phe Leu Asn Phe Asn Leu Ser 
            260                 265                 270         


Asn Cys Glu Arg Lys Glu Glu Arg Val Glu Tyr Tyr Ile Pro Gly Ser 
        275                 280                 285             


Thr Thr Asn Pro Glu Val Phe Lys Leu Glu Asp Lys Gln Pro Gly Asn 
    290                 295                 300                 


Met Ala Gly Asn Phe Asn Leu Ser Leu Gln Gly Cys Asp Gln Asp Ala 
305                 310                 315                 320 


Gln Ser Pro Gly Ile Leu Arg Leu Gln Phe Gln Val Leu Val Gln His 
                325                 330                 335     


Pro Gln Asn Glu Ser Asn Lys Ile Tyr Val Val Asp Leu Ser Asn Glu 
            340                 345                 350         


Arg Ala Met Ser Leu Thr Ile Glu Pro Arg Pro Val Lys Gln Ser Arg 
        355                 360                 365             


Lys Phe Val Pro Gly Cys Phe Val Cys Leu Glu Ser Arg Thr Cys Ser 
    370                 375                 380                 


Ser Asn Leu Thr Leu Thr Ser Gly Ser Lys His Lys Ile Ser Phe Leu 
385                 390                 395                 400 


Cys Asp Asp Leu Thr Arg Leu Trp Met Asn Val Glu Lys Thr Ile Ser 
                405                 410                 415     


Cys Thr Asp His Arg Tyr Cys Gln Arg Lys Ser Tyr Ser Leu Gln Val 
            420                 425                 430         


Pro Ser Asp Ile Leu His Leu Pro Val Glu Leu His Asp Phe Ser Trp 
        435                 440                 445             


Lys Leu Leu Val Pro Lys Asp Arg Leu Ser Leu Val Leu Val Pro Ala 
    450                 455                 460                 


Gln Lys Leu Gln Gln His Thr His Glu Lys Pro Cys Asn Thr Ser Phe 
465                 470                 475                 480 


Ser Tyr Leu Val Ala Ser Ala Ile Pro Ser Gln Asp Leu Tyr Phe Gly 
                485                 490                 495     


Ser Phe Cys Pro Gly Gly Ser Ile Lys Gln Ile Gln Val Lys Gln Asn 
            500                 505                 510         


Ile Ser Val Thr Leu Arg Thr Phe Ala Pro Ser Phe Gln Gln Glu Ala 
        515                 520                 525             


Ser Arg Gln Gly Leu Thr Val Ser Phe Ile Pro Tyr Phe Lys Glu Glu 
    530                 535                 540                 


Gly Val Phe Thr Val Thr Pro Asp Thr Lys Ser Lys Val Tyr Leu Arg 
545                 550                 555                 560 


Thr Pro Asn Trp Asp Arg Gly Leu Pro Ser Leu Thr Ser Val Ser Trp 
                565                 570                 575     


Asn Ile Ser Val Pro Arg Asp Gln Val Ala Cys Leu Thr Phe Phe Lys 
            580                 585                 590         


Glu Arg Ser Gly Val Val Cys Gln Thr Gly Arg Ala Phe Met Ile Ile 
        595                 600                 605             


Gln Glu Gln Arg Thr Arg Ala Glu Glu Ile Phe Ser Leu Asp Glu Asp 
    610                 615                 620                 


Val Leu Pro Lys Pro Ser Phe His His His Ser Phe Trp Val Asn Ile 
625                 630                 635                 640 


Ser Asn Cys Ser Pro Thr Ser Gly Lys Gln Leu Asp Leu Leu Phe Ser 
                645                 650                 655     


Val Thr Leu Thr Pro Arg Thr Val Asp Leu Thr Val Ile Leu Ile Ala 
            660                 665                 670         


Ala Val Gly Gly Gly Val Leu Leu Leu Ser Ala Leu Gly Leu Ile Ile 
        675                 680                 685             


Cys Cys Val Lys Lys Lys Lys Lys Lys Thr Asn Lys Gly Pro Ala Val 
    690                 695                 700                 


Gly Ile Tyr Asn Asp Asn Ile Asn Thr Glu Met Pro Arg Gln Pro Lys 
705                 710                 715                 720 


Lys Phe Gln Lys Gly Arg Lys Asp Asn Asp Ser His Val Tyr Ala Val 
                725                 730                 735     


Ile Glu Asp Thr Met Val Tyr Gly His Leu Leu Gln Asp Ser Ser Gly 
            740                 745                 750         


Ser Phe Leu Gln Pro Glu Val Asp Thr Tyr Arg Pro Phe Gln Gly Thr 
        755                 760                 765             


Met Gly Val Cys Pro Pro Ser Pro Pro Thr Ile Cys Ser Arg Ala Pro 
    770                 775                 780                 


Thr Ala Lys Leu Ala Thr Glu Glu Pro Pro Pro Arg Ser Pro Pro Glu 
785                 790                 795                 800 


Ser Glu Ser Glu Pro Tyr Thr Phe Ser His Pro Asn Asn Gly Asp Val 
                805                 810                 815     


Ser Ser Lys Asp Thr Asp Ile Pro Leu Leu Asn Thr Gln Glu Pro Met 
            820                 825                 830         


Glu Pro Ala Glu 
        835     


<210>  2461
<211>  343
<212>  PRT
<213>  Homo Sapiens

<400>  2461

Met Ala Gly Leu Asn Cys Gly Val Ser Ile Ala Leu Leu Gly Val Leu 
1               5                   10                  15      


Leu Leu Gly Ala Ala Arg Leu Pro Arg Gly Ala Glu Ala Phe Glu Ile 
            20                  25                  30          


Ala Leu Pro Arg Glu Ser Asn Ile Thr Val Leu Ile Lys Leu Gly Thr 
        35                  40                  45              


Pro Thr Leu Leu Ala Lys Pro Cys Tyr Ile Val Ile Ser Lys Arg His 
    50                  55                  60                  


Ile Thr Met Leu Ser Ile Lys Ser Gly Glu Arg Ile Val Phe Thr Phe 
65                  70                  75                  80  


Ser Cys Gln Ser Pro Glu Asn His Phe Val Ile Glu Ile Gln Lys Asn 
                85                  90                  95      


Ile Asp Cys Met Ser Gly Pro Cys Pro Phe Gly Glu Val Gln Leu Gln 
            100                 105                 110         


Pro Ser Thr Ser Leu Leu Pro Thr Leu Asn Arg Thr Phe Ile Trp Asp 
        115                 120                 125             


Val Lys Ala His Lys Ser Ile Gly Leu Glu Leu Gln Phe Ser Ile Pro 
    130                 135                 140                 


Arg Leu Arg Gln Ile Gly Pro Gly Glu Ser Cys Pro Asp Gly Val Thr 
145                 150                 155                 160 


His Ser Ile Ser Gly Arg Ile Asp Ala Thr Val Val Arg Ile Gly Thr 
                165                 170                 175     


Phe Cys Ser Asn Gly Thr Val Ser Arg Ile Lys Met Gln Glu Gly Val 
            180                 185                 190         


Lys Met Ala Leu His Leu Pro Trp Phe His Pro Arg Asn Val Ser Gly 
        195                 200                 205             


Phe Ser Ile Ala Asn Arg Ser Ser Ile Lys Arg Leu Cys Ile Ile Glu 
    210                 215                 220                 


Ser Val Phe Glu Gly Glu Gly Ser Ala Thr Leu Met Ser Ala Asn Tyr 
225                 230                 235                 240 


Pro Glu Gly Phe Pro Glu Asp Glu Leu Met Thr Trp Gln Phe Val Val 
                245                 250                 255     


Pro Ala His Leu Arg Ala Ser Val Ser Phe Leu Asn Phe Asn Leu Ser 
            260                 265                 270         


Asn Cys Glu Arg Lys Glu Glu Arg Val Glu Tyr Tyr Ile Pro Gly Ser 
        275                 280                 285             


Thr Thr Asn Pro Glu Val Phe Lys Leu Glu Asp Lys Gln Pro Gly Asn 
    290                 295                 300                 


Met Ala Gly Asn Phe Asn Leu Ser Leu Gln Gly Cys Asp Gln Asp Ala 
305                 310                 315                 320 


Gln Ser Pro Gly Ile Leu Arg Leu Gln Phe Gln Val Leu Val Gln His 
                325                 330                 335     


Pro Gln Asn Glu Ser Ser Glu 
            340             


<210>  2462
<211>  449
<212>  PRT
<213>  Homo Sapiens

<400>  2462

Met Leu Ala Glu Trp Gly Ala Cys Leu Leu Leu Ala Val Ala Leu Leu 
1               5                   10                  15      


Gly Pro Gly Leu Gln Ala Gln Ala Met Glu Gly Val Lys Cys Gly Gly 
            20                  25                  30          


Val Leu Ser Ala Pro Ser Gly Asn Phe Ser Ser Pro Asn Phe Pro Arg 
        35                  40                  45              


Leu Tyr Pro Tyr Asn Thr Glu Cys Ser Trp Leu Ile Val Val Ala Glu 
    50                  55                  60                  


Gly Ser Ser Val Leu Leu Thr Phe His Ala Phe Asp Leu Glu Tyr His 
65                  70                  75                  80  


Asp Thr Cys Ser Phe Asp Phe Leu Glu Ile Tyr Asn Gly Ala Ser Pro 
                85                  90                  95      


Asp Lys Gly Asn Leu Leu Gly Arg Phe Cys Gly Lys Val Pro Pro Pro 
            100                 105                 110         


Pro Phe Thr Ser Ser Trp His Val Met Ser Val Ile Phe His Ser Asp 
        115                 120                 125             


Lys His Val Ala Ser His Gly Phe Ser Ala Gly Tyr Gln Lys Asp Val 
    130                 135                 140                 


Cys Gly Gly Val Leu Thr Gly Leu Ser Gly Val Leu Thr Ser Pro Glu 
145                 150                 155                 160 


Tyr Pro Asn Asn Tyr Pro Asn Ser Met Glu Cys His Trp Val Ile Arg 
                165                 170                 175     


Ala Ala Gly Pro Ala His Val Lys Leu Val Phe Val Asp Phe Gln Val 
            180                 185                 190         


Glu Gly Asn Glu Glu Cys Thr Tyr Asp Tyr Val Ala Val Leu Gly Gly 
        195                 200                 205             


Pro Gly Pro Thr Arg Gly His His Tyr Cys Gly Ser Thr Arg Pro Pro 
    210                 215                 220                 


Thr Leu Val Ser Leu Gly His Glu Leu Gln Val Val Phe Lys Ser Asp 
225                 230                 235                 240 


Phe Asn Ile Gly Gly Arg Gly Phe Lys Ala Tyr Tyr Phe Ser Gly Glu 
                245                 250                 255     


Cys Gln Glu Val Tyr Met Ala Met Arg Gly Asn Phe Ser Ser Pro Gln 
            260                 265                 270         


Tyr Pro Ser Ser Tyr Pro Asn Asn Ile Arg Cys His Trp Thr Ile Arg 
        275                 280                 285             


Leu Pro Pro Gly Tyr Gln Val Lys Val Phe Phe Leu Asp Leu Asp Leu 
    290                 295                 300                 


Glu Glu Pro Asn Ser Leu Thr Lys Thr Cys Asp Phe Asp His Leu Ala 
305                 310                 315                 320 


Ala Phe Asp Gly Ala Ser Glu Glu Ala Pro Leu Leu Gly Asn Trp Cys 
                325                 330                 335     


Gly His His Leu Pro Pro Pro Val Thr Ser Ser His Asn Gln Leu Leu 
            340                 345                 350         


Leu Leu Leu His Thr Asp Arg Ser Thr Thr Arg Arg Gly Phe Ser Val 
        355                 360                 365             


Ala Tyr Ile Gly Gly Gln Leu Gly Cys Gly Ser Gly Ser Thr Glu Gly 
    370                 375                 380                 


Glu Gly Glu Ala Leu Gln Pro Gln Ser Leu Gln Ser Pro Ser Ser Ile 
385                 390                 395                 400 


Pro Pro Val Cys Pro Ala Pro Pro Met Asn Gly Leu Leu Gln Leu Leu 
                405                 410                 415     


Leu His Trp Leu His Pro Cys Pro Leu Ser Gly Pro Leu Arg Leu Asp 
            420                 425                 430         


Gly Thr Ala Pro Ala Cys Phe His Tyr Cys Arg Ala Ser Phe Pro Ser 
        435                 440                 445             


Phe 
    


<210>  2463
<211>  540
<212>  PRT
<213>  Homo Sapiens

<400>  2463

Met Leu Ala Glu Trp Gly Ala Cys Leu Leu Leu Ala Val Ala Leu Leu 
1               5                   10                  15      


Gly Pro Gly Leu Gln Ala Gln Ala Met Glu Gly Val Lys Cys Gly Gly 
            20                  25                  30          


Val Leu Ser Ala Pro Ser Gly Asn Phe Ser Ser Pro Asn Phe Pro Arg 
        35                  40                  45              


Leu Tyr Pro Tyr Asn Thr Glu Cys Ser Trp Leu Ile Val Val Ala Glu 
    50                  55                  60                  


Gly Ser Ser Val Leu Leu Thr Phe His Ala Phe Asp Leu Glu Tyr His 
65                  70                  75                  80  


Asp Thr Cys Ser Phe Asp Phe Leu Glu Ile Tyr Asn Gly Ala Ser Pro 
                85                  90                  95      


Asp Lys Gly Asn Leu Leu Gly Arg Phe Cys Gly Lys Val Pro Pro Pro 
            100                 105                 110         


Pro Phe Thr Ser Ser Trp His Val Met Ser Val Ile Phe His Ser Asp 
        115                 120                 125             


Lys His Val Ala Ser His Gly Phe Ser Ala Gly Tyr Gln Lys Asp Val 
    130                 135                 140                 


Cys Gly Gly Val Leu Thr Gly Leu Ser Gly Val Leu Thr Ser Pro Glu 
145                 150                 155                 160 


Tyr Pro Asn Asn Tyr Pro Asn Ser Met Glu Cys His Trp Val Ile Arg 
                165                 170                 175     


Ala Ala Gly Pro Ala His Val Lys Leu Val Phe Val Asp Phe Gln Val 
            180                 185                 190         


Glu Gly Asn Glu Glu Cys Thr Tyr Asp Tyr Val Ala Val Leu Gly Gly 
        195                 200                 205             


Pro Gly Pro Thr Arg Gly His His Tyr Cys Gly Ser Thr Arg Pro Pro 
    210                 215                 220                 


Thr Leu Val Ser Leu Gly His Glu Leu Gln Val Val Phe Lys Ser Asp 
225                 230                 235                 240 


Phe Asn Ile Gly Gly Arg Gly Phe Lys Ala Tyr Tyr Phe Ser Gly Glu 
                245                 250                 255     


Cys Gln Glu Val Tyr Met Ala Met Arg Gly Asn Phe Ser Ser Pro Gln 
            260                 265                 270         


Tyr Pro Ser Ser Tyr Pro Asn Asn Ile Arg Cys His Trp Thr Ile Arg 
        275                 280                 285             


Leu Pro Pro Gly Tyr Gln Val Lys Val Phe Phe Leu Asp Leu Asp Leu 
    290                 295                 300                 


Glu Glu Pro Asn Ser Leu Thr Lys Thr Cys Asp Phe Asp His Leu Ala 
305                 310                 315                 320 


Ala Phe Asp Gly Ala Ser Glu Glu Ala Pro Leu Leu Gly Asn Trp Cys 
                325                 330                 335     


Gly His His Leu Pro Pro Pro Val Thr Ser Ser His Asn Gln Leu Leu 
            340                 345                 350         


Leu Leu Leu His Thr Asp Arg Ser Thr Thr Arg Arg Gly Phe Ser Val 
        355                 360                 365             


Ala Tyr Ile Gly Val Val Pro Met Asn Val Ser Cys Ser Arg Thr Asp 
    370                 375                 380                 


Phe Gln Ile Leu Ile Ser Thr Gln Ala Leu Ala Pro Leu Glu Arg Thr 
385                 390                 395                 400 


Lys Val Tyr Leu Gly Ser Arg Ser Cys Ala Ala Gln Glu Val Gly Gly 
                405                 410                 415     


Asn Leu Arg Ile Gln Ala Arg Phe Asp Thr Cys Gly Thr Glu Ser Gln 
            420                 425                 430         


Arg Arg Asn Asn Thr Ser Val Ile Val Ser Val Leu Tyr Ile Asp Phe 
        435                 440                 445             


Ser Ala Ala Gly Arg Glu Asp Ile His Glu Tyr Glu Val Arg Cys Glu 
    450                 455                 460                 


Pro Arg Arg Lys Glu Ala Ser Val His Leu Leu Ser Gly Ser His Trp 
465                 470                 475                 480 


Leu Gly Pro Tyr Ala Ala Thr Ala Glu His Leu Gln Glu Ala Pro Pro 
                485                 490                 495     


Met Asp Glu Ala Glu Ala Leu Glu Gly Pro Val Ser Met Val Ala Gln 
            500                 505                 510         


Asp Thr Ser Asp Ile Val Phe Leu Gly Leu Cys Ile Leu Ala Gly Ile 
        515                 520                 525             


Leu Met Val Ile Ala Ile Val Val Leu Met Leu Leu 
    530                 535                 540 


<210>  2464
<211>  882
<212>  PRT
<213>  Homo Sapiens

<400>  2464

Met Gly Pro Trp Ser Arg Ser Leu Ser Ala Leu Leu Leu Leu Leu Gln 
1               5                   10                  15      


Val Ser Ser Trp Leu Cys Gln Glu Pro Glu Pro Cys His Pro Gly Phe 
            20                  25                  30          


Asp Ala Glu Ser Tyr Thr Phe Thr Val Pro Arg Arg His Leu Glu Arg 
        35                  40                  45              


Gly Arg Val Leu Gly Arg Val Asn Phe Glu Asp Cys Thr Gly Arg Gln 
    50                  55                  60                  


Arg Thr Ala Tyr Phe Ser Leu Asp Thr Arg Phe Lys Val Gly Thr Asp 
65                  70                  75                  80  


Gly Val Ile Thr Val Lys Arg Pro Leu Arg Phe His Asn Pro Gln Ile 
                85                  90                  95      


His Phe Leu Val Tyr Ala Trp Asp Ser Thr Tyr Arg Lys Phe Ser Thr 
            100                 105                 110         


Lys Val Thr Leu Asn Thr Val Gly His His His Arg Pro Pro Pro His 
        115                 120                 125             


Gln Ala Ser Val Ser Gly Ile Gln Ala Glu Leu Leu Thr Phe Pro Asn 
    130                 135                 140                 


Ser Ser Pro Gly Leu Arg Arg Gln Lys Arg Asp Trp Val Ile Pro Pro 
145                 150                 155                 160 


Ile Ser Cys Pro Glu Asn Glu Lys Gly Pro Phe Pro Lys Asn Leu Val 
                165                 170                 175     


Gln Ile Lys Ser Asn Lys Asp Lys Glu Gly Lys Val Phe Tyr Ser Ile 
            180                 185                 190         


Thr Gly Gln Gly Ala Asp Thr Pro Pro Val Gly Val Phe Ile Ile Glu 
        195                 200                 205             


Arg Glu Thr Gly Trp Leu Lys Val Thr Glu Pro Leu Asp Arg Glu Arg 
    210                 215                 220                 


Ile Ala Thr Tyr Thr Leu Phe Ser His Ala Val Ser Ser Asn Gly Asn 
225                 230                 235                 240 


Ala Val Glu Asp Pro Met Glu Ile Leu Ile Thr Val Thr Asp Gln Asn 
                245                 250                 255     


Asp Asn Lys Pro Glu Phe Thr Gln Glu Val Phe Lys Gly Ser Val Met 
            260                 265                 270         


Glu Gly Ala Leu Pro Gly Thr Ser Val Met Glu Val Thr Ala Thr Asp 
        275                 280                 285             


Ala Asp Asp Asp Val Asn Thr Tyr Asn Ala Ala Ile Ala Tyr Thr Ile 
    290                 295                 300                 


Leu Ser Gln Asp Pro Glu Leu Pro Asp Lys Asn Met Phe Thr Ile Asn 
305                 310                 315                 320 


Arg Asn Thr Gly Val Ile Ser Val Val Thr Thr Gly Leu Asp Arg Glu 
                325                 330                 335     


Ser Phe Pro Thr Tyr Thr Leu Val Val Gln Ala Ala Asp Leu Gln Gly 
            340                 345                 350         


Glu Gly Leu Ser Thr Thr Ala Thr Ala Val Ile Thr Val Thr Asp Thr 
        355                 360                 365             


Asn Asp Asn Pro Pro Ile Phe Asn Pro Thr Thr Tyr Lys Gly Gln Val 
    370                 375                 380                 


Pro Glu Asn Glu Ala Asn Val Val Ile Thr Thr Leu Lys Val Thr Asp 
385                 390                 395                 400 


Ala Asp Ala Pro Asn Thr Pro Ala Trp Glu Ala Val Tyr Thr Ile Leu 
                405                 410                 415     


Asn Asp Asp Gly Gly Gln Phe Val Val Thr Thr Asn Pro Val Asn Asn 
            420                 425                 430         


Asp Gly Ile Leu Lys Thr Ala Lys Gly Leu Asp Phe Glu Ala Lys Gln 
        435                 440                 445             


Gln Tyr Ile Leu His Val Ala Val Thr Asn Val Val Pro Phe Glu Val 
    450                 455                 460                 


Ser Leu Thr Thr Ser Thr Ala Thr Val Thr Val Asp Val Leu Asp Val 
465                 470                 475                 480 


Asn Glu Ala Pro Ile Phe Val Pro Pro Glu Lys Arg Val Glu Val Ser 
                485                 490                 495     


Glu Asp Phe Gly Val Gly Gln Glu Ile Thr Ser Tyr Thr Ala Gln Glu 
            500                 505                 510         


Pro Asp Thr Phe Met Glu Gln Lys Ile Thr Tyr Arg Ile Trp Arg Asp 
        515                 520                 525             


Thr Ala Asn Trp Leu Glu Ile Asn Pro Asp Thr Gly Ala Ile Ser Thr 
    530                 535                 540                 


Arg Ala Glu Leu Asp Arg Glu Asp Phe Glu His Val Lys Asn Ser Thr 
545                 550                 555                 560 


Tyr Thr Ala Leu Ile Ile Ala Thr Asp Asn Gly Ser Pro Val Ala Thr 
                565                 570                 575     


Gly Thr Gly Thr Leu Leu Leu Ile Leu Ser Asp Val Asn Asp Asn Ala 
            580                 585                 590         


Pro Ile Pro Glu Pro Arg Thr Ile Phe Phe Cys Glu Arg Asn Pro Lys 
        595                 600                 605             


Pro Gln Val Ile Asn Ile Ile Asp Ala Asp Leu Pro Pro Asn Thr Ser 
    610                 615                 620                 


Pro Phe Thr Ala Glu Leu Thr His Gly Ala Ser Ala Asn Trp Thr Ile 
625                 630                 635                 640 


Gln Tyr Asn Asp Pro Thr Gln Glu Ser Ile Ile Leu Lys Pro Lys Met 
                645                 650                 655     


Ala Leu Glu Val Gly Asp Tyr Lys Ile Asn Leu Lys Leu Met Asp Asn 
            660                 665                 670         


Gln Asn Lys Asp Gln Val Thr Thr Leu Glu Val Ser Val Cys Asp Cys 
        675                 680                 685             


Glu Gly Ala Ala Gly Val Cys Arg Lys Ala Gln Pro Val Glu Ala Gly 
    690                 695                 700                 


Leu Gln Ile Pro Ala Ile Leu Gly Ile Leu Gly Gly Ile Leu Ala Leu 
705                 710                 715                 720 


Leu Ile Leu Ile Leu Leu Leu Leu Leu Phe Leu Arg Arg Arg Ala Val 
                725                 730                 735     


Val Lys Glu Pro Leu Leu Pro Pro Glu Asp Asp Thr Arg Asp Asn Val 
            740                 745                 750         


Tyr Tyr Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp Phe Asp 
        755                 760                 765             


Leu Ser Gln Leu His Arg Gly Leu Asp Ala Arg Pro Glu Val Thr Arg 
    770                 775                 780                 


Asn Asp Val Ala Pro Thr Leu Met Ser Val Pro Arg Tyr Leu Pro Arg 
785                 790                 795                 800 


Pro Ala Asn Pro Asp Glu Ile Gly Asn Phe Ile Asp Glu Asn Leu Lys 
                805                 810                 815     


Ala Ala Asp Thr Asp Pro Thr Ala Pro Pro Tyr Asp Ser Leu Leu Val 
            820                 825                 830         


Phe Asp Tyr Glu Gly Ser Gly Ser Glu Ala Ala Ser Leu Ser Ser Leu 
        835                 840                 845             


Asn Ser Ser Glu Ser Asp Lys Asp Gln Asp Tyr Asp Tyr Leu Asn Glu 
    850                 855                 860                 


Trp Gly Asn Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly Gly Gly Glu 
865                 870                 875                 880 


Asp Asp 
        


<210>  2465
<211>  821
<212>  PRT
<213>  Homo Sapiens

<400>  2465

Met Gly Pro Trp Ser Arg Ser Leu Ser Ala Leu Leu Leu Leu Leu Gln 
1               5                   10                  15      


Val Ser Ser Trp Leu Cys Gln Glu Pro Glu Pro Cys His Pro Gly Phe 
            20                  25                  30          


Asp Ala Glu Ser Tyr Thr Phe Thr Val Pro Arg Arg His Leu Glu Arg 
        35                  40                  45              


Gly Arg Val Leu Gly Arg Val Asn Phe Glu Asp Cys Thr Gly Arg Gln 
    50                  55                  60                  


Arg Thr Ala Tyr Phe Ser Leu Asp Thr Arg Phe Lys Val Gly Thr Asp 
65                  70                  75                  80  


Gly Val Ile Thr Val Lys Arg Pro Leu Arg Phe His Asn Pro Gln Ile 
                85                  90                  95      


His Phe Leu Val Tyr Ala Trp Asp Ser Thr Tyr Arg Lys Phe Ser Thr 
            100                 105                 110         


Lys Val Thr Leu Asn Thr Val Gly His His His Arg Pro Pro Pro His 
        115                 120                 125             


Gln Ala Ser Val Ser Gly Ile Gln Ala Glu Leu Leu Thr Phe Pro Asn 
    130                 135                 140                 


Ser Ser Pro Gly Leu Arg Arg Gln Lys Arg Asp Trp Val Ile Pro Pro 
145                 150                 155                 160 


Ile Ser Cys Pro Glu Asn Glu Lys Gly Pro Phe Pro Lys Asn Leu Val 
                165                 170                 175     


Gln Ile Lys Ser Asn Lys Asp Lys Glu Gly Lys Val Phe Tyr Ser Ile 
            180                 185                 190         


Thr Gly Gln Gly Ala Asp Thr Pro Pro Val Gly Val Phe Ile Ile Glu 
        195                 200                 205             


Arg Glu Thr Gly Trp Leu Lys Val Thr Glu Pro Leu Asp Arg Glu Arg 
    210                 215                 220                 


Ile Ala Thr Tyr Thr Leu Phe Ser His Ala Val Ser Ser Asn Gly Asn 
225                 230                 235                 240 


Ala Val Glu Asp Pro Met Glu Ile Leu Ile Thr Val Thr Asp Gln Asn 
                245                 250                 255     


Asp Asn Lys Pro Glu Phe Thr Gln Glu Val Phe Lys Gly Ser Val Met 
            260                 265                 270         


Glu Gly Ala Leu Pro Gly Thr Ser Val Met Glu Val Thr Ala Thr Asp 
        275                 280                 285             


Ala Asp Asp Asp Val Asn Thr Tyr Asn Ala Ala Ile Ala Tyr Thr Ile 
    290                 295                 300                 


Leu Ser Gln Asp Pro Glu Leu Pro Asp Lys Asn Met Phe Thr Ile Asn 
305                 310                 315                 320 


Arg Asn Thr Gly Val Ile Ser Val Val Thr Thr Gly Leu Asp Arg Glu 
                325                 330                 335     


Ser Phe Pro Thr Tyr Thr Leu Val Val Gln Ala Ala Asp Leu Gln Gly 
            340                 345                 350         


Glu Gly Leu Ser Thr Thr Ala Thr Ala Val Ile Thr Val Thr Asp Thr 
        355                 360                 365             


Asn Asp Asn Pro Pro Ile Phe Asn Pro Thr Thr Gly Leu Asp Phe Glu 
    370                 375                 380                 


Ala Lys Gln Gln Tyr Ile Leu His Val Ala Val Thr Asn Val Val Pro 
385                 390                 395                 400 


Phe Glu Val Ser Leu Thr Thr Ser Thr Ala Thr Val Thr Val Asp Val 
                405                 410                 415     


Leu Asp Val Asn Glu Ala Pro Ile Phe Val Pro Pro Glu Lys Arg Val 
            420                 425                 430         


Glu Val Ser Glu Asp Phe Gly Val Gly Gln Glu Ile Thr Ser Tyr Thr 
        435                 440                 445             


Ala Gln Glu Pro Asp Thr Phe Met Glu Gln Lys Ile Thr Tyr Arg Ile 
    450                 455                 460                 


Trp Arg Asp Thr Ala Asn Trp Leu Glu Ile Asn Pro Asp Thr Gly Ala 
465                 470                 475                 480 


Ile Ser Thr Arg Ala Glu Leu Asp Arg Glu Asp Phe Glu His Val Lys 
                485                 490                 495     


Asn Ser Thr Tyr Thr Ala Leu Ile Ile Ala Thr Asp Asn Gly Ser Pro 
            500                 505                 510         


Val Ala Thr Gly Thr Gly Thr Leu Leu Leu Ile Leu Ser Asp Val Asn 
        515                 520                 525             


Asp Asn Ala Pro Ile Pro Glu Pro Arg Thr Ile Phe Phe Cys Glu Arg 
    530                 535                 540                 


Asn Pro Lys Pro Gln Val Ile Asn Ile Ile Asp Ala Asp Leu Pro Pro 
545                 550                 555                 560 


Asn Thr Ser Pro Phe Thr Ala Glu Leu Thr His Gly Ala Ser Ala Asn 
                565                 570                 575     


Trp Thr Ile Gln Tyr Asn Asp Pro Thr Gln Glu Ser Ile Ile Leu Lys 
            580                 585                 590         


Pro Lys Met Ala Leu Glu Val Gly Asp Tyr Lys Ile Asn Leu Lys Leu 
        595                 600                 605             


Met Asp Asn Gln Asn Lys Asp Gln Val Thr Thr Leu Glu Val Ser Val 
    610                 615                 620                 


Cys Asp Cys Glu Gly Ala Ala Gly Val Cys Arg Lys Ala Gln Pro Val 
625                 630                 635                 640 


Glu Ala Gly Leu Gln Ile Pro Ala Ile Leu Gly Ile Leu Gly Gly Ile 
                645                 650                 655     


Leu Ala Leu Leu Ile Leu Ile Leu Leu Leu Leu Leu Phe Leu Arg Arg 
            660                 665                 670         


Arg Ala Val Val Lys Glu Pro Leu Leu Pro Pro Glu Asp Asp Thr Arg 
        675                 680                 685             


Asp Asn Val Tyr Tyr Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln 
    690                 695                 700                 


Asp Phe Asp Leu Ser Gln Leu His Arg Gly Leu Asp Ala Arg Pro Glu 
705                 710                 715                 720 


Val Thr Arg Asn Asp Val Ala Pro Thr Leu Met Ser Val Pro Arg Tyr 
                725                 730                 735     


Leu Pro Arg Pro Ala Asn Pro Asp Glu Ile Gly Asn Phe Ile Asp Glu 
            740                 745                 750         


Asn Leu Lys Ala Ala Asp Thr Asp Pro Thr Ala Pro Pro Tyr Asp Ser 
        755                 760                 765             


Leu Leu Val Phe Asp Tyr Glu Gly Ser Gly Ser Glu Ala Ala Ser Leu 
    770                 775                 780                 


Ser Ser Leu Asn Ser Ser Glu Ser Asp Lys Asp Gln Asp Tyr Asp Tyr 
785                 790                 795                 800 


Leu Asn Glu Trp Gly Asn Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly 
                805                 810                 815     


Gly Gly Glu Asp Asp 
            820     


<210>  2466
<211>  537
<212>  PRT
<213>  Homo Sapiens

<400>  2466

Met Gly Pro Trp Ser Arg Ser Leu Ser Ala Leu Leu Leu Leu Leu Gln 
1               5                   10                  15      


Val Ser Ser Trp Leu Cys Gln Glu Pro Glu Pro Cys His Pro Gly Phe 
            20                  25                  30          


Asp Ala Glu Ser Tyr Thr Phe Thr Val Pro Arg Arg His Leu Glu Arg 
        35                  40                  45              


Gly Arg Val Leu Gly Arg Val Asn Phe Glu Asp Cys Thr Gly Arg Gln 
    50                  55                  60                  


Arg Thr Ala Tyr Phe Ser Leu Asp Thr Arg Phe Lys Val Gly Thr Asp 
65                  70                  75                  80  


Gly Val Ile Thr Val Lys Arg Pro Leu Arg Phe His Asn Pro Gln Ile 
                85                  90                  95      


His Phe Leu Val Tyr Ala Trp Asp Ser Thr Tyr Arg Lys Phe Ser Thr 
            100                 105                 110         


Lys Val Thr Leu Asn Thr Val Gly His His His Arg Pro Pro Pro His 
        115                 120                 125             


Gln Ala Ser Val Ser Gly Ile Gln Ala Glu Leu Leu Thr Phe Pro Asn 
    130                 135                 140                 


Ser Ser Pro Gly Leu Arg Arg Gln Lys Arg Asp Trp Val Ile Pro Pro 
145                 150                 155                 160 


Ile Ser Cys Pro Glu Asn Glu Lys Gly Pro Phe Pro Lys Asn Leu Val 
                165                 170                 175     


Gln Ile Lys Ser Asn Lys Asp Lys Glu Gly Lys Val Phe Tyr Ser Ile 
            180                 185                 190         


Thr Gly Gln Gly Ala Asp Thr Pro Pro Val Gly Val Phe Ile Ile Glu 
        195                 200                 205             


Arg Glu Thr Gly Trp Leu Lys Val Thr Glu Pro Leu Asp Arg Glu Arg 
    210                 215                 220                 


Ile Ala Thr Tyr Thr Leu Phe Ser His Ala Val Ser Ser Asn Gly Asn 
225                 230                 235                 240 


Ala Val Glu Asp Pro Met Glu Ile Leu Ile Thr Val Thr Asp Gln Asn 
                245                 250                 255     


Asp Asn Lys Pro Glu Phe Thr Gln Glu Val Phe Lys Gly Ser Val Met 
            260                 265                 270         


Glu Gly Ala Leu Pro Gly Thr Ser Val Met Glu Val Thr Ala Thr Asp 
        275                 280                 285             


Ala Asp Asp Asp Val Asn Thr Tyr Asn Ala Ala Ile Ala Tyr Thr Ile 
    290                 295                 300                 


Leu Ser Gln Asp Pro Glu Leu Pro Asp Lys Asn Met Phe Thr Ile Asn 
305                 310                 315                 320 


Arg Asn Thr Gly Val Ile Ser Val Val Thr Thr Gly Leu Asp Arg Glu 
                325                 330                 335     


Ser Phe Pro Thr Tyr Thr Leu Val Val Gln Ala Ala Asp Leu Gln Gly 
            340                 345                 350         


Glu Gly Leu Ser Thr Thr Ala Thr Ala Val Ile Thr Val Thr Asp Thr 
        355                 360                 365             


Asn Asp Asn Pro Pro Ile Phe Asn Pro Thr Thr Tyr Lys Gly Gln Val 
    370                 375                 380                 


Pro Glu Asn Glu Ala Asn Val Val Ile Thr Thr Leu Lys Val Thr Asp 
385                 390                 395                 400 


Ala Asp Ala Pro Asn Thr Pro Ala Trp Glu Ala Val Tyr Thr Ile Leu 
                405                 410                 415     


Asn Asp Asp Gly Gly Gln Phe Val Val Thr Thr Asn Pro Val Asn Asn 
            420                 425                 430         


Asp Gly Ile Leu Lys Thr Ala Lys Gly Leu Asp Phe Glu Ala Lys Gln 
        435                 440                 445             


Gln Tyr Ile Leu His Val Ala Val Thr Asn Val Val Pro Phe Glu Val 
    450                 455                 460                 


Ser Leu Thr Thr Ser Thr Ala Thr Val Thr Val Asp Val Leu Asp Val 
465                 470                 475                 480 


Asn Glu Ala Pro Ile Phe Val Pro Pro Glu Lys Arg Val Glu Val Ser 
                485                 490                 495     


Glu Asp Phe Gly Val Gly Gln Glu Ile Thr Ser Tyr Thr Ala Gln Glu 
            500                 505                 510         


Pro Asp Thr Phe Met Glu Gln Lys Ile Thr Phe Ser Ser Cys Tyr Trp 
        515                 520                 525             


Asn Arg Asp Thr Ser Ala Asp Pro Val 
    530                 535         


<210>  2467
<211>  647
<212>  PRT
<213>  Homo Sapiens

<400>  2467

Met Gly Pro Trp Ser Arg Ser Leu Ser Ala Leu Leu Leu Leu Leu Gln 
1               5                   10                  15      


Val Ser Ser Trp Leu Cys Gln Glu Pro Glu Pro Cys His Pro Gly Phe 
            20                  25                  30          


Asp Ala Glu Ser Tyr Thr Phe Thr Val Pro Arg Arg His Leu Glu Arg 
        35                  40                  45              


Gly Arg Val Leu Gly Arg Val Asn Phe Glu Asp Cys Thr Gly Arg Gln 
    50                  55                  60                  


Arg Thr Ala Tyr Phe Ser Leu Asp Thr Arg Phe Lys Val Gly Thr Asp 
65                  70                  75                  80  


Gly Val Ile Thr Val Lys Arg Pro Leu Arg Phe His Asn Pro Gln Ile 
                85                  90                  95      


His Phe Leu Val Tyr Ala Trp Asp Ser Thr Tyr Arg Lys Phe Ser Thr 
            100                 105                 110         


Lys Val Thr Leu Asn Thr Val Gly His His His Arg Pro Pro Pro His 
        115                 120                 125             


Gln Ala Ser Val Ser Gly Ile Gln Ala Glu Leu Leu Thr Phe Pro Asn 
    130                 135                 140                 


Ser Ser Pro Gly Leu Arg Arg Gln Lys Arg Asp Trp Val Ile Pro Pro 
145                 150                 155                 160 


Ile Ser Cys Pro Glu Asn Glu Lys Gly Pro Phe Pro Lys Asn Leu Val 
                165                 170                 175     


Gln Ile Lys Ser Asn Lys Asp Lys Glu Gly Lys Val Phe Tyr Ser Ile 
            180                 185                 190         


Thr Gly Gln Gly Ala Asp Thr Pro Pro Val Gly Val Phe Ile Ile Glu 
        195                 200                 205             


Arg Glu Thr Gly Trp Leu Lys Val Thr Glu Pro Leu Asp Arg Glu Arg 
    210                 215                 220                 


Ile Ala Thr Tyr Thr Leu Phe Ser His Ala Val Ser Ser Asn Gly Asn 
225                 230                 235                 240 


Ala Val Glu Asp Pro Met Glu Ile Leu Ile Thr Val Thr Asp Gln Asn 
                245                 250                 255     


Asp Asn Lys Pro Glu Phe Thr Gln Glu Val Phe Lys Gly Ser Val Met 
            260                 265                 270         


Glu Gly Ala Leu Pro Gly Thr Ser Val Met Glu Val Thr Ala Thr Asp 
        275                 280                 285             


Ala Asp Asp Asp Val Asn Thr Tyr Asn Ala Ala Ile Ala Tyr Thr Ile 
    290                 295                 300                 


Leu Ser Gln Asp Pro Glu Leu Pro Asp Lys Asn Met Phe Thr Ile Asn 
305                 310                 315                 320 


Arg Asn Thr Gly Val Ile Ser Val Val Thr Thr Gly Leu Asp Arg Glu 
                325                 330                 335     


Ser Phe Pro Thr Tyr Thr Leu Val Val Gln Ala Ala Asp Leu Gln Gly 
            340                 345                 350         


Glu Gly Leu Ser Thr Thr Ala Thr Ala Val Ile Thr Val Thr Asp Thr 
        355                 360                 365             


Asn Asp Asn Pro Pro Ile Phe Asn Pro Thr Thr Tyr Lys Gly Gln Val 
    370                 375                 380                 


Pro Glu Asn Glu Ala Asn Val Val Ile Thr Thr Leu Lys Val Thr Asp 
385                 390                 395                 400 


Ala Asp Ala Pro Asn Thr Pro Ala Trp Glu Ala Val Tyr Thr Ile Leu 
                405                 410                 415     


Asn Asp Asp Gly Gly Gln Phe Val Val Thr Thr Asn Pro Val Asn Asn 
            420                 425                 430         


Asp Gly Ile Leu Lys Thr Ala Lys Gly Leu Asp Phe Glu Ala Lys Gln 
        435                 440                 445             


Gln Tyr Ile Leu His Val Ala Val Thr Asn Val Val Pro Phe Glu Val 
    450                 455                 460                 


Ser Leu Thr Thr Ser Thr Ala Thr Val Thr Val Asp Val Leu Asp Val 
465                 470                 475                 480 


Asn Glu Ala Pro Ile Phe Val Pro Pro Glu Lys Arg Val Glu Val Ser 
                485                 490                 495     


Glu Asp Phe Gly Val Gly Gln Glu Ile Thr Ser Tyr Thr Ala Gln Glu 
            500                 505                 510         


Pro Asp Thr Phe Met Glu Gln Lys Ile Thr Tyr Arg Ile Trp Arg Asp 
        515                 520                 525             


Thr Ala Asn Trp Leu Glu Ile Asn Pro Asp Thr Gly Ala Ile Ser Thr 
    530                 535                 540                 


Arg Ala Glu Leu Asp Arg Glu Asp Phe Glu His Val Lys Asn Ser Thr 
545                 550                 555                 560 


Tyr Thr Ala Leu Ile Ile Ala Thr Asp Asn Gly Ser Pro Val Ala Thr 
                565                 570                 575     


Gly Thr Gly Thr Leu Leu Leu Ile Leu Ser Asp Val Asn Asp Asn Ala 
            580                 585                 590         


Pro Ile Pro Glu Pro Arg Thr Ile Phe Phe Cys Glu Arg Asn Pro Lys 
        595                 600                 605             


Pro Gln Val Ile Asn Ile Ile Asp Ala Asp Leu Pro Pro Asn Leu Ala 
    610                 615                 620                 


Ser Gln Ser Ile Gly Ile Thr Asp Met Ser His Cys Thr Cys Pro Ala 
625                 630                 635                 640 


Pro Gln Leu Pro Ala Ile Phe 
                645         


<210>  2468
<211>  903
<212>  PRT
<213>  Homo Sapiens

<400>  2468

Met Gly Pro Trp Ser Arg Ser Leu Ser Ala Leu Leu Leu Leu Leu Gln 
1               5                   10                  15      


Val Ser Ser Trp Leu Cys Gln Glu Pro Glu Pro Cys His Pro Gly Phe 
            20                  25                  30          


Asp Ala Glu Ser Tyr Thr Phe Thr Val Pro Arg Arg His Leu Glu Arg 
        35                  40                  45              


Gly Arg Val Leu Gly Arg Val Asn Phe Glu Asp Cys Thr Gly Arg Gln 
    50                  55                  60                  


Arg Thr Ala Tyr Phe Ser Leu Asp Thr Arg Phe Lys Val Gly Thr Asp 
65                  70                  75                  80  


Gly Val Ile Thr Val Lys Arg Pro Leu Arg Phe His Asn Pro Gln Ile 
                85                  90                  95      


His Phe Leu Val Tyr Ala Trp Asp Ser Thr Tyr Arg Lys Phe Ser Thr 
            100                 105                 110         


Lys Val Thr Leu Asn Thr Val Gly His His His Arg Pro Pro Pro His 
        115                 120                 125             


Gln Ala Ser Val Ser Gly Ile Gln Ala Glu Leu Leu Thr Phe Pro Asn 
    130                 135                 140                 


Ser Ser Pro Gly Leu Arg Arg Gln Lys Arg Asp Trp Val Ile Pro Pro 
145                 150                 155                 160 


Ile Ser Cys Pro Glu Asn Glu Lys Gly Pro Phe Pro Lys Asn Leu Val 
                165                 170                 175     


Gln Ile Lys Ser Asn Lys Asp Lys Glu Gly Lys Val Phe Tyr Ser Ile 
            180                 185                 190         


Thr Gly Gln Gly Ala Asp Thr Pro Pro Val Gly Val Phe Ile Ile Glu 
        195                 200                 205             


Arg Glu Thr Gly Trp Leu Lys Val Thr Glu Pro Leu Asp Arg Glu Arg 
    210                 215                 220                 


Ile Ala Thr Tyr Thr Leu Phe Ser His Ala Val Ser Ser Asn Gly Asn 
225                 230                 235                 240 


Ala Val Glu Asp Pro Met Glu Ile Leu Ile Thr Val Thr Asp Gln Asn 
                245                 250                 255     


Asp Asn Lys Pro Glu Phe Thr Gln Glu Val Phe Lys Gly Ser Val Met 
            260                 265                 270         


Glu Gly Ala Leu Pro Gly Thr Ser Val Met Glu Val Thr Ala Thr Asp 
        275                 280                 285             


Ala Asp Asp Asp Val Asn Thr Tyr Asn Ala Ala Ile Ala Tyr Thr Ile 
    290                 295                 300                 


Leu Ser Gln Asp Pro Glu Leu Pro Asp Lys Asn Met Phe Thr Ile Asn 
305                 310                 315                 320 


Arg Asn Thr Gly Val Ile Ser Val Val Thr Thr Gly Leu Asp Arg Glu 
                325                 330                 335     


Ser Phe Pro Thr Tyr Thr Leu Val Val Gln Ala Ala Asp Leu Gln Gly 
            340                 345                 350         


Glu Gly Leu Ser Thr Thr Ala Thr Ala Val Ile Thr Val Thr Asp Thr 
        355                 360                 365             


Asn Asp Asn Pro Pro Ile Phe Asn Pro Thr Thr Tyr Lys Gly Gln Val 
    370                 375                 380                 


Pro Glu Asn Glu Ala Asn Val Val Ile Thr Thr Leu Lys Val Thr Asp 
385                 390                 395                 400 


Ala Asp Ala Pro Asn Thr Pro Ala Trp Glu Ala Val Tyr Thr Ile Leu 
                405                 410                 415     


Asn Asp Asp Gly Gly Gln Phe Val Val Thr Thr Asn Pro Val Asn Asn 
            420                 425                 430         


Asp Gly Ile Leu Lys Thr Ala Lys Val Trp Tyr Leu Ala Arg Cys Arg 
        435                 440                 445             


Asn Trp His Pro His Ser Cys Ser Tyr Pro Cys Pro Leu Gly Leu Asp 
    450                 455                 460                 


Phe Glu Ala Lys Gln Gln Tyr Ile Leu His Val Ala Val Thr Asn Val 
465                 470                 475                 480 


Val Pro Phe Glu Val Ser Leu Thr Thr Ser Thr Ala Thr Val Thr Val 
                485                 490                 495     


Asp Val Leu Asp Val Asn Glu Ala Pro Ile Phe Val Pro Pro Glu Lys 
            500                 505                 510         


Arg Val Glu Val Ser Glu Asp Phe Gly Val Gly Gln Glu Ile Thr Ser 
        515                 520                 525             


Tyr Thr Ala Gln Glu Pro Asp Thr Phe Met Glu Gln Lys Ile Thr Tyr 
    530                 535                 540                 


Arg Ile Trp Arg Asp Thr Ala Asn Trp Leu Glu Ile Asn Pro Asp Thr 
545                 550                 555                 560 


Gly Ala Ile Ser Thr Arg Ala Glu Leu Asp Arg Glu Asp Phe Glu His 
                565                 570                 575     


Val Lys Asn Ser Thr Tyr Thr Ala Leu Ile Ile Ala Thr Asp Asn Gly 
            580                 585                 590         


Ser Pro Val Ala Thr Gly Thr Gly Thr Leu Leu Leu Ile Leu Ser Asp 
        595                 600                 605             


Val Asn Asp Asn Ala Pro Ile Pro Glu Pro Arg Thr Ile Phe Phe Cys 
    610                 615                 620                 


Glu Arg Asn Pro Lys Pro Gln Val Ile Asn Ile Ile Asp Ala Asp Leu 
625                 630                 635                 640 


Pro Pro Asn Thr Ser Pro Phe Thr Ala Glu Leu Thr His Gly Ala Ser 
                645                 650                 655     


Ala Asn Trp Thr Ile Gln Tyr Asn Asp Pro Thr Gln Glu Ser Ile Ile 
            660                 665                 670         


Leu Lys Pro Lys Met Ala Leu Glu Val Gly Asp Tyr Lys Ile Asn Leu 
        675                 680                 685             


Lys Leu Met Asp Asn Gln Asn Lys Asp Gln Val Thr Thr Leu Glu Val 
    690                 695                 700                 


Ser Val Cys Asp Cys Glu Gly Ala Ala Gly Val Cys Arg Lys Ala Gln 
705                 710                 715                 720 


Pro Val Glu Ala Gly Leu Gln Ile Pro Ala Ile Leu Gly Ile Leu Gly 
                725                 730                 735     


Gly Ile Leu Ala Leu Leu Ile Leu Ile Leu Leu Leu Leu Leu Phe Leu 
            740                 745                 750         


Arg Arg Arg Ala Val Val Lys Glu Pro Leu Leu Pro Pro Glu Asp Asp 
        755                 760                 765             


Thr Arg Asp Asn Val Tyr Tyr Tyr Asp Glu Glu Gly Gly Gly Glu Glu 
    770                 775                 780                 


Asp Gln Asp Phe Asp Leu Ser Gln Leu His Arg Gly Leu Asp Ala Arg 
785                 790                 795                 800 


Pro Glu Val Thr Arg Asn Asp Val Ala Pro Thr Leu Met Ser Val Pro 
                805                 810                 815     


Arg Tyr Leu Pro Arg Pro Ala Asn Pro Asp Glu Ile Gly Asn Phe Ile 
            820                 825                 830         


Asp Glu Asn Leu Lys Ala Ala Asp Thr Asp Pro Thr Ala Pro Pro Tyr 
        835                 840                 845             


Asp Ser Leu Leu Val Phe Asp Tyr Glu Gly Ser Gly Ser Glu Ala Ala 
    850                 855                 860                 


Ser Leu Ser Ser Leu Asn Ser Ser Glu Ser Asp Lys Asp Gln Asp Tyr 
865                 870                 875                 880 


Asp Tyr Leu Asn Glu Trp Gly Asn Arg Phe Lys Lys Leu Ala Asp Met 
                885                 890                 895     


Tyr Gly Gly Gly Glu Asp Asp 
            900             


<210>  2469
<211>  647
<212>  PRT
<213>  Homo Sapiens

<400>  2469

Met Gly Pro Trp Ser Arg Ser Leu Ser Ala Leu Leu Leu Leu Leu Gln 
1               5                   10                  15      


Val Ser Ser Trp Leu Cys Gln Glu Pro Glu Pro Cys His Pro Gly Phe 
            20                  25                  30          


Asp Ala Glu Ser Tyr Thr Phe Thr Val Pro Arg Arg His Leu Glu Arg 
        35                  40                  45              


Gly Arg Val Leu Gly Arg Val Asn Phe Glu Asp Cys Thr Gly Arg Gln 
    50                  55                  60                  


Arg Thr Ala Tyr Phe Ser Leu Asp Thr Arg Phe Lys Val Gly Thr Asp 
65                  70                  75                  80  


Gly Val Ile Thr Val Lys Arg Pro Leu Arg Phe His Asn Pro Gln Ile 
                85                  90                  95      


His Phe Leu Val Tyr Ala Trp Asp Ser Thr Tyr Arg Lys Phe Ser Thr 
            100                 105                 110         


Lys Val Thr Leu Asn Thr Val Gly His His His Arg Pro Pro Pro His 
        115                 120                 125             


Gln Ala Ser Val Ser Gly Ile Gln Ala Glu Leu Leu Thr Phe Pro Asn 
    130                 135                 140                 


Ser Ser Pro Gly Leu Arg Arg Gln Lys Arg Asp Trp Val Ile Pro Pro 
145                 150                 155                 160 


Ile Ser Cys Pro Glu Asn Glu Lys Gly Pro Phe Pro Lys Asn Leu Val 
                165                 170                 175     


Gln Ile Lys Ser Asn Lys Asp Lys Glu Gly Lys Val Phe Tyr Ser Ile 
            180                 185                 190         


Thr Gly Gln Gly Ala Asp Thr Pro Pro Val Gly Val Phe Ile Ile Glu 
        195                 200                 205             


Arg Glu Thr Gly Trp Leu Lys Val Thr Glu Pro Leu Asp Arg Glu Arg 
    210                 215                 220                 


Ile Ala Thr Tyr Thr Leu Phe Ser His Ala Val Ser Ser Asn Gly Asn 
225                 230                 235                 240 


Ala Val Glu Asp Pro Met Glu Ile Leu Ile Thr Val Thr Asp Gln Asn 
                245                 250                 255     


Asp Asn Lys Pro Glu Phe Thr Gln Glu Val Phe Lys Gly Ser Val Met 
            260                 265                 270         


Glu Gly Ala Leu Pro Gly Thr Ser Val Met Glu Val Thr Ala Thr Asp 
        275                 280                 285             


Ala Asp Asp Asp Val Asn Thr Tyr Asn Ala Ala Ile Ala Tyr Thr Ile 
    290                 295                 300                 


Leu Ser Gln Asp Pro Glu Leu Pro Asp Lys Asn Met Phe Thr Ile Asn 
305                 310                 315                 320 


Arg Asn Thr Gly Val Ile Ser Val Val Thr Thr Gly Leu Asp Arg Glu 
                325                 330                 335     


Ser Phe Pro Thr Tyr Thr Leu Val Val Gln Ala Ala Asp Leu Gln Gly 
            340                 345                 350         


Glu Gly Leu Ser Thr Thr Ala Thr Ala Val Ile Thr Val Thr Asp Thr 
        355                 360                 365             


Asn Asp Asn Pro Pro Ile Phe Asn Pro Thr Thr Tyr Lys Gly Gln Val 
    370                 375                 380                 


Pro Glu Asn Glu Ala Asn Val Val Ile Thr Thr Leu Lys Val Thr Asp 
385                 390                 395                 400 


Ala Asp Ala Pro Asn Thr Pro Ala Trp Glu Ala Val Tyr Thr Ile Leu 
                405                 410                 415     


Asn Asp Asp Gly Gly Gln Phe Val Val Thr Thr Asn Pro Val Asn Asn 
            420                 425                 430         


Asp Gly Ile Leu Lys Thr Ala Lys Gly Leu Asp Phe Glu Ala Lys Gln 
        435                 440                 445             


Gln Tyr Ile Leu His Val Ala Val Thr Asn Val Val Pro Phe Glu Val 
    450                 455                 460                 


Ser Leu Thr Thr Ser Thr Ala Thr Val Thr Val Asp Val Leu Asp Val 
465                 470                 475                 480 


Asn Glu Ala Pro Ile Phe Val Pro Pro Glu Lys Arg Val Glu Val Ser 
                485                 490                 495     


Glu Asp Phe Gly Val Gly Gln Glu Ile Thr Ser Tyr Thr Ala Gln Glu 
            500                 505                 510         


Pro Asp Thr Phe Met Glu Gln Lys Ile Thr Tyr Arg Ile Trp Arg Asp 
        515                 520                 525             


Thr Ala Asn Trp Leu Glu Ile Asn Pro Asp Thr Gly Ala Ile Ser Thr 
    530                 535                 540                 


Arg Ala Glu Leu Asp Arg Glu Asp Phe Glu His Val Lys Asn Ser Thr 
545                 550                 555                 560 


Tyr Thr Ala Leu Ile Ile Ala Thr Asp Asn Gly Ser Pro Val Ala Thr 
                565                 570                 575     


Gly Thr Gly Thr Leu Leu Leu Ile Leu Ser Asp Val Asn Asp Asn Ala 
            580                 585                 590         


Pro Ile Pro Glu Pro Arg Thr Ile Phe Phe Cys Glu Arg Asn Pro Lys 
        595                 600                 605             


Pro Gln Val Ala Gly Leu Leu Glu Pro Ser Asp Pro Pro Ile Leu Ala 
    610                 615                 620                 


Ser Gln Ser Ile Gly Ile Thr Asp Met Ser His Cys Thr Cys Pro Ala 
625                 630                 635                 640 


Pro Gln Leu Pro Ala Ile Phe 
                645         


<210>  2470
<211>  414
<212>  PRT
<213>  Homo Sapiens

<400>  2470

Met Gly Pro Trp Ser Arg Ser Leu Ser Ala Leu Leu Leu Leu Leu Gln 
1               5                   10                  15      


Val Ser Ser Trp Leu Cys Gln Glu Pro Glu Pro Cys His Pro Gly Phe 
            20                  25                  30          


Asp Ala Glu Ser Tyr Thr Phe Thr Val Pro Arg Arg His Leu Glu Arg 
        35                  40                  45              


Gly Arg Val Leu Gly Arg Val Asn Phe Glu Asp Cys Thr Gly Arg Gln 
    50                  55                  60                  


Arg Thr Ala Tyr Phe Ser Leu Asp Thr Arg Phe Lys Val Gly Thr Asp 
65                  70                  75                  80  


Gly Val Ile Thr Val Lys Arg Pro Leu Arg Phe His Asn Pro Gln Ile 
                85                  90                  95      


His Phe Leu Val Tyr Ala Trp Asp Ser Thr Tyr Arg Lys Phe Ser Thr 
            100                 105                 110         


Lys Val Thr Leu Asn Thr Val Gly His His His Arg Pro Pro Pro His 
        115                 120                 125             


Gln Ala Ser Val Ser Gly Ile Gln Ala Glu Leu Leu Thr Phe Pro Asn 
    130                 135                 140                 


Ser Ser Pro Gly Leu Arg Arg Gln Lys Arg Asp Trp Val Ile Pro Pro 
145                 150                 155                 160 


Ile Ser Cys Pro Glu Asn Glu Lys Gly Pro Phe Pro Lys Asn Leu Val 
                165                 170                 175     


Gln Leu Phe Ser His Ala Val Ser Ser Asn Gly Asn Ala Val Glu Asp 
            180                 185                 190         


Pro Met Glu Ile Leu Ile Thr Val Thr Asp Gln Asn Asp Asn Lys Pro 
        195                 200                 205             


Glu Phe Thr Gln Glu Val Phe Lys Gly Ser Val Met Glu Gly Ala Leu 
    210                 215                 220                 


Pro Gly Thr Ser Val Met Glu Val Thr Ala Thr Asp Ala Asp Asp Asp 
225                 230                 235                 240 


Val Asn Thr Tyr Asn Ala Ala Ile Ala Tyr Thr Ile Leu Ser Gln Asp 
                245                 250                 255     


Pro Glu Leu Pro Asp Lys Asn Met Phe Thr Ile Asn Arg Asn Thr Gly 
            260                 265                 270         


Val Ile Ser Val Val Thr Thr Gly Leu Asp Arg Glu Ser Phe Pro Thr 
        275                 280                 285             


Tyr Thr Leu Val Val Gln Ala Ala Asp Leu Gln Gly Glu Gly Leu Ser 
    290                 295                 300                 


Thr Thr Ala Thr Ala Val Ile Thr Val Thr Asp Thr Asn Asp Asn Pro 
305                 310                 315                 320 


Pro Ile Phe Asn Pro Thr Thr Tyr Lys Gly Gln Val Pro Glu Asn Glu 
                325                 330                 335     


Ala Asn Val Val Ile Thr Thr Leu Lys Val Thr Asp Ala Asp Ala Pro 
            340                 345                 350         


Asn Thr Pro Ala Trp Glu Ala Val Tyr Thr Ile Leu Asn Asp Asp Gly 
        355                 360                 365             


Gly Gln Phe Val Val Thr Thr Asn Pro Val Asn Asn Asp Gly Ile Leu 
    370                 375                 380                 


Lys Thr Ala Lys Val Cys Met Val Pro Gly Lys Met Gln Lys Leu Ala 
385                 390                 395                 400 


Ser Ser Gln Leu Phe Ile Pro Leu Ser Pro Gly Leu Gly Phe 
                405                 410                 


<210>  2471
<211>  155
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2471

Xaa Thr Asp Gly Val Ile Thr Val Lys Arg Pro Leu Arg Phe His Asn 
1               5                   10                  15      


Pro Gln Ile His Phe Leu Val Tyr Ala Trp Asp Ser Thr Tyr Arg Lys 
            20                  25                  30          


Phe Ser Thr Lys Val Thr Leu Asn Thr Val Gly His His His Arg Pro 
        35                  40                  45              


Pro Pro His Gln Ala Ser Val Ser Gly Ile Gln Ala Glu Leu Leu Thr 
    50                  55                  60                  


Phe Pro Asn Ser Ser Pro Gly Leu Arg Arg Gln Lys Arg Asp Trp Val 
65                  70                  75                  80  


Ile Pro Pro Ile Ser Cys Pro Glu Asn Glu Lys Gly Pro Phe Pro Lys 
                85                  90                  95      


Asn Leu Val Gln Ile Lys Ser Asn Lys Asp Lys Glu Gly Lys Val Phe 
            100                 105                 110         


Tyr Ser Ile Thr Gly Gln Gly Ala Asp Thr Pro Pro Val Gly Val Phe 
        115                 120                 125             


Ile Ile Glu Arg Glu Thr Gly Trp Leu Lys Val Thr Glu Pro Leu Asp 
    130                 135                 140                 


Arg Glu Arg Ile Ala Thr Tyr Thr Glu Pro Leu 
145                 150                 155 


<210>  2472
<211>  670
<212>  PRT
<213>  Homo Sapiens

<400>  2472

Met Ala Gln Ala Val Asp Arg Asp Thr Asn Arg Pro Leu Glu Pro Pro 
1               5                   10                  15      


Ser Glu Phe Ile Val Lys Val Gln Asp Ile Asn Asp Asn Pro Pro Glu 
            20                  25                  30          


Phe Leu His Glu Thr Tyr His Ala Asn Val Pro Glu Arg Ser Asn Val 
        35                  40                  45              


Gly Thr Ser Val Ile Gln Val Thr Ala Ser Asp Ala Asp Asp Pro Thr 
    50                  55                  60                  


Tyr Gly Asn Ser Ala Lys Leu Val Tyr Ser Ile Leu Glu Gly Gln Pro 
65                  70                  75                  80  


Tyr Phe Ser Val Glu Ala Gln Thr Gly Ile Ile Arg Thr Ala Leu Pro 
                85                  90                  95      


Asn Met Asp Arg Glu Ala Lys Glu Glu Tyr His Val Val Ile Gln Ala 
            100                 105                 110         


Lys Asp Met Gly Gly His Met Gly Gly Leu Ser Gly Thr Thr Lys Val 
        115                 120                 125             


Thr Ile Thr Leu Thr Asp Val Asn Asp Asn Pro Pro Lys Phe Pro Gln 
    130                 135                 140                 


Ser Val Tyr Gln Met Ser Val Ser Glu Ala Ala Val Pro Gly Glu Glu 
145                 150                 155                 160 


Val Gly Arg Val Lys Ala Lys Asp Pro Asp Ile Gly Glu Asn Gly Leu 
                165                 170                 175     


Val Thr Tyr Asn Ile Val Asp Gly Asp Gly Met Glu Ser Phe Glu Ile 
            180                 185                 190         


Thr Thr Asp Tyr Glu Thr Gln Glu Gly Val Ile Lys Leu Lys Lys Pro 
        195                 200                 205             


Val Asp Phe Glu Thr Lys Arg Ala Tyr Ser Leu Lys Val Glu Ala Ala 
    210                 215                 220                 


Asn Val His Ile Asp Pro Lys Phe Ile Ser Asn Gly Pro Phe Lys Asp 
225                 230                 235                 240 


Thr Val Thr Val Lys Ile Ser Val Glu Asp Ala Asp Glu Pro Pro Met 
                245                 250                 255     


Phe Leu Ala Pro Ser Tyr Ile His Glu Val Gln Glu Asn Ala Ala Ala 
            260                 265                 270         


Gly Thr Val Val Gly Arg Val His Ala Lys Asp Pro Asp Ala Ala Asn 
        275                 280                 285             


Ser Pro Ile Arg Tyr Ser Ile Asp Arg His Thr Asp Leu Asp Arg Phe 
    290                 295                 300                 


Phe Thr Ile Asn Pro Glu Asp Gly Phe Ile Lys Thr Thr Lys Pro Leu 
305                 310                 315                 320 


Asp Arg Glu Glu Thr Ala Trp Leu Asn Ile Thr Val Phe Ala Ala Glu 
                325                 330                 335     


Ile His Asn Arg His Gln Glu Ala Lys Val Pro Val Ala Ile Arg Val 
            340                 345                 350         


Leu Asp Val Asn Asp Asn Ala Pro Lys Phe Ala Ala Pro Tyr Glu Gly 
        355                 360                 365             


Phe Ile Cys Glu Ser Asp Gln Thr Lys Pro Leu Ser Asn Gln Pro Ile 
    370                 375                 380                 


Val Thr Ile Ser Ala Asp Asp Lys Asp Asp Thr Ala Asn Gly Pro Arg 
385                 390                 395                 400 


Phe Ile Phe Ser Leu Pro Pro Glu Ile Ile His Asn Pro Asn Phe Thr 
                405                 410                 415     


Val Arg Asp Asn Arg Asp Asn Thr Ala Gly Val Tyr Ala Arg Arg Gly 
            420                 425                 430         


Gly Phe Ser Arg Gln Lys Gln Asp Leu Tyr Leu Leu Pro Ile Val Ile 
        435                 440                 445             


Ser Asp Gly Gly Ile Pro Pro Met Ser Ser Thr Asn Thr Leu Thr Ile 
    450                 455                 460                 


Lys Val Cys Gly Cys Asp Val Asn Gly Ala Leu Leu Ser Cys Asn Ala 
465                 470                 475                 480 


Glu Ala Tyr Ile Leu Asn Ala Gly Leu Ser Thr Gly Ala Leu Ile Ala 
                485                 490                 495     


Ile Leu Ala Cys Ile Val Ile Leu Leu Val Ile Val Val Leu Phe Val 
            500                 505                 510         


Thr Leu Arg Arg Gln Lys Lys Glu Pro Leu Ile Val Phe Glu Glu Glu 
        515                 520                 525             


Asp Val Arg Glu Asn Ile Ile Thr Tyr Asp Asp Glu Gly Gly Gly Glu 
    530                 535                 540                 


Glu Asp Thr Glu Ala Phe Asp Ile Ala Thr Leu Gln Asn Pro Asp Gly 
545                 550                 555                 560 


Ile Asn Gly Phe Ile Pro Arg Lys Asp Ile Lys Pro Glu Tyr Gln Tyr 
                565                 570                 575     


Met Pro Arg Pro Gly Leu Arg Pro Ala Pro Asn Ser Val Asp Val Asp 
            580                 585                 590         


Asp Phe Ile Asn Thr Arg Ile Gln Glu Ala Asp Asn Asp Pro Thr Ala 
        595                 600                 605             


Pro Pro Tyr Asp Ser Ile Gln Ile Tyr Gly Tyr Glu Gly Arg Gly Ser 
    610                 615                 620                 


Val Ala Gly Ser Leu Ser Ser Leu Glu Ser Ala Thr Thr Asp Ser Asp 
625                 630                 635                 640 


Leu Asp Tyr Asp Tyr Leu Gln Asn Trp Gly Pro Arg Phe Lys Lys Leu 
                645                 650                 655     


Ala Asp Leu Tyr Gly Ser Lys Asp Thr Phe Asp Asp Asp Ser 
            660                 665                 670 


<210>  2473
<211>  22
<212>  PRT
<213>  Homo Sapiens

<400>  2473

Met Lys Glu Asn Tyr Cys Leu Gln Ala Ala Leu Val Cys Leu Gly Met 
1               5                   10                  15      


Leu Cys His Ser His Ala 
            20          


<210>  2474
<211>  34
<212>  PRT
<213>  Homo Sapiens

<400>  2474

Met Lys Glu Asn Tyr Cys Leu Gln Ala Ala Leu Val Cys Leu Gly Met 
1               5                   10                  15      


Leu Cys His Ser His Ala Phe Ala Pro Glu Arg Arg Gly His Leu Arg 
            20                  25                  30          


Pro Ser 
        


<210>  2475
<211>  54
<212>  PRT
<213>  Homo Sapiens

<400>  2475

Met Lys Glu Asn Tyr Cys Leu Gln Ala Ala Leu Val Cys Leu Gly Met 
1               5                   10                  15      


Leu Cys His Ser His Ala Phe Ala Pro Glu Arg Arg Gly His Leu Arg 
            20                  25                  30          


Pro Ser Phe His Gly His His Glu Lys Gly Lys Glu Gly Gln Val Leu 
        35                  40                  45              


Gln Arg Ser Lys Arg Gly 
    50                  


<210>  2476
<211>  65
<212>  PRT
<213>  Homo Sapiens

<400>  2476

Met Lys Glu Asn Tyr Cys Leu Gln Ala Ala Leu Val Cys Leu Gly Met 
1               5                   10                  15      


Leu Cys His Ser His Ala Phe Ala Pro Glu Arg Arg Gly His Leu Arg 
            20                  25                  30          


Pro Ser Phe His Gly His His Glu Lys Gly Lys Glu Gly Gln Val Leu 
        35                  40                  45              


Gln Arg Ser Lys Arg Gly Trp Val Trp Asn Gln Phe Phe Val Ile Glu 
    50                  55                  60                  


Glu 
65  


<210>  2477
<211>  70
<212>  PRT
<213>  Homo Sapiens

<400>  2477

Met Lys Glu Asn Tyr Cys Leu Gln Ala Ala Leu Val Cys Leu Gly Met 
1               5                   10                  15      


Leu Cys His Ser His Ala Phe Ala Pro Glu Arg Arg Gly His Leu Arg 
            20                  25                  30          


Pro Ser Phe His Gly His His Glu Lys Gly Lys Glu Gly Gln Val Leu 
        35                  40                  45              


Gln Arg Ser Lys Arg Gly Trp Val Trp Asn Gln Phe Phe Val Ile Glu 
    50                  55                  60                  


Glu Tyr Thr Gly Pro Asp 
65                  70  


<210>  2478
<211>  222
<212>  PRT
<213>  Homo Sapiens

<400>  2478

Met Lys Glu Asn Tyr Cys Leu Gln Ala Ala Leu Val Cys Leu Gly Met 
1               5                   10                  15      


Leu Cys His Ser His Ala Phe Ala Pro Glu Arg Arg Gly His Leu Arg 
            20                  25                  30          


Pro Ser Phe His Gly His His Glu Lys Gly Lys Glu Gly Gln Val Leu 
        35                  40                  45              


Gln Arg Ser Lys Arg Gly Trp Val Trp Asn Gln Phe Phe Val Ile Glu 
    50                  55                  60                  


Glu Tyr Thr Gly Pro Asp Pro Val Leu Val Gly Arg Leu His Ser Asp 
65                  70                  75                  80  


Ile Asp Ser Gly Asp Gly Asn Ile Lys Tyr Ile Leu Ser Gly Glu Gly 
                85                  90                  95      


Ala Gly Thr Ile Phe Val Ile Asp Asp Lys Ser Gly Asn Ile His Ala 
            100                 105                 110         


Thr Lys Thr Leu Asp Arg Glu Glu Arg Ala Gln Tyr Thr Leu Met Ala 
        115                 120                 125             


Gln Ala Val Asp Arg Asp Thr Asn Arg Pro Leu Glu Pro Pro Ser Glu 
    130                 135                 140                 


Phe Ile Val Lys Val Gln Asp Ile Asn Asp Asn Pro Pro Glu Phe Leu 
145                 150                 155                 160 


His Glu Thr Tyr His Ala Asn Val Pro Glu Arg Ser Asn Val Gly Thr 
                165                 170                 175     


Ser Val Ile Gln Val Thr Ala Ser Asp Ala Asp Asp Pro Thr Tyr Gly 
            180                 185                 190         


Asn Ser Ala Lys Leu Val Tyr Ser Ile Leu Glu Gly Gln Pro Tyr Phe 
        195                 200                 205             


Ser Val Glu Ala Gln Thr Gly Ile Ile Arg Thr Ala Leu Pro 
    210                 215                 220         


<210>  2479
<211>  796
<212>  PRT
<213>  Homo Sapiens

<400>  2479

Met Lys Glu Asn Tyr Cys Leu Gln Ala Ala Leu Val Cys Leu Gly Met 
1               5                   10                  15      


Leu Cys His Ser His Ala Phe Ala Pro Glu Arg Arg Gly His Leu Arg 
            20                  25                  30          


Pro Ser Phe His Gly His His Glu Lys Gly Lys Glu Gly Gln Val Leu 
        35                  40                  45              


Gln Arg Ser Lys Arg Gly Trp Val Trp Asn Gln Phe Phe Val Ile Glu 
    50                  55                  60                  


Glu Tyr Thr Gly Pro Asp Pro Val Leu Val Gly Arg Leu His Ser Asp 
65                  70                  75                  80  


Ile Asp Ser Gly Asp Gly Asn Ile Lys Tyr Ile Leu Ser Gly Glu Gly 
                85                  90                  95      


Ala Gly Thr Ile Phe Val Ile Asp Asp Lys Ser Gly Asn Ile His Ala 
            100                 105                 110         


Thr Lys Thr Leu Asp Arg Glu Glu Arg Ala Gln Tyr Thr Leu Met Ala 
        115                 120                 125             


Gln Ala Val Asp Arg Asp Thr Asn Arg Pro Leu Glu Pro Pro Ser Glu 
    130                 135                 140                 


Phe Ile Val Lys Val Gln Asp Ile Asn Asp Asn Pro Pro Glu Phe Leu 
145                 150                 155                 160 


His Glu Thr Tyr His Ala Asn Val Pro Glu Arg Ser Asn Val Gly Thr 
                165                 170                 175     


Ser Val Ile Gln Val Thr Ala Ser Asp Ala Asp Asp Pro Thr Tyr Gly 
            180                 185                 190         


Asn Ser Ala Lys Leu Val Tyr Ser Ile Leu Glu Gly Gln Pro Tyr Phe 
        195                 200                 205             


Ser Val Glu Ala Gln Thr Gly Ile Ile Arg Thr Ala Leu Pro Asn Met 
    210                 215                 220                 


Asp Arg Glu Ala Lys Glu Glu Tyr His Val Val Ile Gln Ala Lys Asp 
225                 230                 235                 240 


Met Gly Gly His Met Gly Gly Leu Ser Gly Thr Thr Lys Val Thr Ile 
                245                 250                 255     


Thr Leu Thr Asp Val Asn Asp Asn Pro Pro Lys Phe Pro Gln Ser Val 
            260                 265                 270         


Tyr Gln Met Ser Val Ser Glu Ala Ala Val Pro Gly Glu Glu Val Gly 
        275                 280                 285             


Arg Val Lys Ala Lys Asp Pro Asp Ile Gly Glu Asn Gly Leu Val Thr 
    290                 295                 300                 


Tyr Asn Ile Val Asp Gly Asp Gly Met Glu Ser Phe Glu Ile Thr Thr 
305                 310                 315                 320 


Asp Tyr Glu Thr Gln Glu Gly Val Ile Lys Leu Lys Lys Pro Val Asp 
                325                 330                 335     


Phe Glu Thr Lys Arg Ala Tyr Ser Leu Lys Val Glu Ala Ala Asn Val 
            340                 345                 350         


His Ile Asp Pro Lys Phe Ile Ser Asn Gly Pro Phe Lys Asp Thr Val 
        355                 360                 365             


Thr Val Lys Ile Ser Val Glu Asp Ala Asp Glu Pro Pro Met Phe Leu 
    370                 375                 380                 


Ala Pro Ser Tyr Ile His Glu Val Gln Glu Asn Ala Ala Ala Gly Thr 
385                 390                 395                 400 


Val Val Gly Arg Val His Ala Lys Asp Pro Asp Ala Ala Asn Ser Pro 
                405                 410                 415     


Ile Arg Tyr Ser Ile Asp Arg His Thr Asp Leu Asp Arg Phe Phe Thr 
            420                 425                 430         


Ile Asn Pro Glu Asp Gly Phe Ile Lys Thr Thr Lys Pro Leu Asp Arg 
        435                 440                 445             


Glu Glu Thr Ala Trp Leu Asn Ile Thr Val Phe Ala Ala Glu Ile His 
    450                 455                 460                 


Asn Arg His Gln Glu Ala Lys Val Pro Val Ala Ile Arg Val Leu Asp 
465                 470                 475                 480 


Val Asn Asp Asn Ala Pro Lys Phe Ala Ala Pro Tyr Glu Gly Phe Ile 
                485                 490                 495     


Cys Glu Ser Asp Gln Thr Lys Pro Leu Ser Asn Gln Pro Ile Val Thr 
            500                 505                 510         


Ile Ser Ala Asp Asp Lys Asp Asp Thr Ala Asn Gly Pro Arg Phe Ile 
        515                 520                 525             


Phe Ser Leu Pro Pro Glu Ile Ile His Asn Pro Asn Phe Thr Val Arg 
    530                 535                 540                 


Asp Asn Arg Asp Asn Thr Ala Gly Val Tyr Ala Arg Arg Gly Gly Phe 
545                 550                 555                 560 


Ser Arg Gln Lys Gln Asp Leu Tyr Leu Leu Pro Ile Val Ile Ser Asp 
                565                 570                 575     


Gly Gly Ile Pro Pro Met Ser Ser Thr Asn Thr Leu Thr Ile Lys Val 
            580                 585                 590         


Cys Gly Cys Asp Val Asn Gly Ala Leu Leu Ser Cys Asn Ala Glu Ala 
        595                 600                 605             


Tyr Ile Leu Asn Ala Gly Leu Ser Thr Gly Ala Leu Ile Ala Ile Leu 
    610                 615                 620                 


Ala Cys Ile Val Ile Leu Leu Val Ile Val Val Leu Phe Val Thr Leu 
625                 630                 635                 640 


Arg Arg Gln Lys Lys Glu Pro Leu Ile Val Phe Glu Glu Glu Asp Val 
                645                 650                 655     


Arg Glu Asn Ile Ile Thr Tyr Asp Asp Glu Gly Gly Gly Glu Glu Asp 
            660                 665                 670         


Thr Glu Ala Phe Asp Ile Ala Thr Leu Gln Asn Pro Asp Gly Ile Asn 
        675                 680                 685             


Gly Phe Ile Pro Arg Lys Asp Ile Lys Pro Glu Tyr Gln Tyr Met Pro 
    690                 695                 700                 


Arg Pro Gly Leu Arg Pro Ala Pro Asn Ser Val Asp Val Asp Asp Phe 
705                 710                 715                 720 


Ile Asn Thr Arg Ile Gln Glu Ala Asp Asn Asp Pro Thr Ala Pro Pro 
                725                 730                 735     


Tyr Asp Ser Ile Gln Ile Tyr Gly Tyr Glu Gly Arg Gly Ser Val Ala 
            740                 745                 750         


Gly Ser Leu Ser Ser Leu Glu Ser Ala Thr Thr Asp Ser Asp Leu Asp 
        755                 760                 765             


Tyr Asp Tyr Leu Gln Asn Trp Gly Pro Arg Phe Lys Lys Leu Ala Asp 
    770                 775                 780                 


Leu Tyr Gly Ser Lys Asp Thr Phe Asp Asp Asp Ser 
785                 790                 795     


<210>  2480
<211>  693
<212>  PRT
<213>  Homo Sapiens

<400>  2480

Met Lys Glu Asn Tyr Cys Leu Gln Ala Ala Leu Val Cys Leu Gly Met 
1               5                   10                  15      


Leu Cys His Ser His Ala Phe Ala Pro Glu Arg Arg Gly His Leu Arg 
            20                  25                  30          


Pro Ser Phe His Gly His His Glu Lys Gly Lys Glu Gly Gln Val Leu 
        35                  40                  45              


Gln Arg Ser Lys Arg Gly Trp Val Trp Asn Gln Phe Phe Val Ile Glu 
    50                  55                  60                  


Glu Tyr Thr Gly Pro Asp Pro Val Leu Val Gly Arg Leu His Ser Asp 
65                  70                  75                  80  


Ile Asp Ser Gly Asp Gly Asn Ile Lys Tyr Ile Leu Ser Gly Glu Gly 
                85                  90                  95      


Ala Gly Thr Ile Phe Val Ile Asp Asp Lys Ser Gly Asn Ile His Ala 
            100                 105                 110         


Thr Lys Thr Leu Asp Arg Glu Glu Arg Ala Gln Tyr Thr Leu Met Ala 
        115                 120                 125             


Gln Ala Val Asp Arg Asp Thr Asn Arg Pro Leu Glu Pro Pro Ser Glu 
    130                 135                 140                 


Phe Ile Val Lys Val Gln Asp Ile Asn Asp Asn Pro Pro Glu Phe Leu 
145                 150                 155                 160 


His Glu Thr Tyr His Ala Asn Val Pro Glu Arg Ser Asn Val Gly Thr 
                165                 170                 175     


Ser Val Ile Gln Val Thr Ala Ser Asp Ala Asp Asp Pro Thr Tyr Gly 
            180                 185                 190         


Asn Ser Ala Lys Leu Val Tyr Ser Ile Leu Glu Gly Gln Pro Tyr Phe 
        195                 200                 205             


Ser Val Glu Ala Gln Thr Gly Ile Ile Arg Thr Ala Leu Pro Asn Met 
    210                 215                 220                 


Asp Arg Glu Ala Lys Glu Glu Tyr His Val Val Ile Gln Ala Lys Asp 
225                 230                 235                 240 


Met Gly Gly His Met Gly Gly Leu Ser Gly Thr Thr Lys Val Thr Ile 
                245                 250                 255     


Thr Leu Thr Asp Val Asn Asp Asn Pro Pro Lys Phe Pro Gln Ser Val 
            260                 265                 270         


Tyr Gln Met Ser Val Ser Glu Ala Ala Val Pro Gly Glu Glu Val Gly 
        275                 280                 285             


Arg Val Lys Ala Lys Asp Pro Asp Ile Gly Glu Asn Gly Leu Val Thr 
    290                 295                 300                 


Tyr Asn Ile Val Asp Gly Asp Gly Met Glu Ser Phe Glu Ile Thr Thr 
305                 310                 315                 320 


Asp Tyr Glu Thr Gln Glu Gly Val Ile Lys Leu Lys Lys Pro Val Asp 
                325                 330                 335     


Phe Glu Thr Lys Arg Ala Tyr Ser Leu Lys Val Glu Ala Ala Asn Val 
            340                 345                 350         


His Ile Asp Pro Lys Phe Ile Ser Asn Gly Pro Phe Lys Asp Thr Val 
        355                 360                 365             


Thr Val Lys Ile Ser Val Glu Asp Ala Asp Glu Pro Pro Met Phe Leu 
    370                 375                 380                 


Ala Pro Ser Tyr Ile His Glu Val Gln Glu Asn Ala Ala Ala Gly Thr 
385                 390                 395                 400 


Val Val Gly Arg Val His Ala Lys Asp Pro Asp Ala Ala Asn Ser Pro 
                405                 410                 415     


Ile Arg Tyr Ser Ile Asp Arg His Thr Asp Leu Asp Arg Phe Phe Thr 
            420                 425                 430         


Ile Asn Pro Glu Asp Gly Phe Ile Lys Thr Thr Lys Pro Leu Asp Arg 
        435                 440                 445             


Glu Glu Thr Ala Trp Leu Asn Ile Thr Val Phe Ala Ala Glu Ile His 
    450                 455                 460                 


Asn Arg His Gln Glu Ala Lys Val Pro Val Ala Ile Arg Val Leu Asp 
465                 470                 475                 480 


Val Asn Asp Asn Ala Pro Lys Phe Ala Ala Pro Tyr Glu Gly Phe Ile 
                485                 490                 495     


Cys Glu Ser Asp Gln Thr Lys Pro Leu Ser Asn Gln Pro Ile Val Thr 
            500                 505                 510         


Ile Ser Ala Asp Asp Lys Asp Asp Thr Ala Asn Gly Pro Arg Phe Ile 
        515                 520                 525             


Phe Ser Leu Pro Pro Glu Ile Ile His Asn Pro Asn Phe Thr Val Arg 
    530                 535                 540                 


Asp Asn Arg Asp Asn Thr Ala Gly Val Tyr Ala Arg Arg Gly Gly Phe 
545                 550                 555                 560 


Ser Arg Gln Lys Gln Asp Leu Tyr Leu Leu Pro Ile Val Ile Ser Asp 
                565                 570                 575     


Gly Gly Ile Pro Pro Met Ser Ser Thr Asn Thr Leu Thr Ile Lys Val 
            580                 585                 590         


Cys Gly Cys Asp Val Asn Gly Ala Leu Leu Ser Cys Asn Ala Glu Ala 
        595                 600                 605             


Tyr Ile Leu Asn Ala Gly Leu Ser Thr Gly Ala Leu Ile Ala Ile Leu 
    610                 615                 620                 


Ala Cys Ile Val Ile Leu Leu Gly Cys Pro Ser Leu Met Glu Pro Pro 
625                 630                 635                 640 


Ser Pro Arg Glu Asp Met Arg Leu Leu Tyr Leu Gly Phe Gln Leu Met 
                645                 650                 655     


Leu Phe Ser Tyr Val Lys Val Asn Arg Arg Phe Cys Leu Leu Gly Val 
            660                 665                 670         


Phe Ile Lys Leu Pro Phe Leu Tyr Val Val Ala Thr Glu Ser Pro Thr 
        675                 680                 685             


Thr Leu Thr Ser Leu 
    690             


<210>  2481
<211>  62
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2481

Xaa Met Ser Val Ser Glu Ala Ala Val Pro Gly Glu Glu Val Gly Arg 
1               5                   10                  15      


Val Lys Ala Lys Asp Pro Asp Ile Gly Glu Asn Gly Leu Val Thr Tyr 
            20                  25                  30          


Asn Ile Val Asp Gly Asp Gly Met Glu Ser Phe Glu Ile Thr Thr Asp 
        35                  40                  45              


Tyr Glu Thr Gln Glu Gly Val Ile Lys Leu Lys Lys Val Ser 
    50                  55                  60          


<210>  2482
<211>  760
<212>  PRT
<213>  Homo Sapiens

<400>  2482

Met Lys Thr Pro Pro Gly Ala Ser Ser Arg Thr Lys Cys Ser Arg Glu 
1               5                   10                  15      


Leu Arg Ser Phe Cys Ala Phe Ser Cys Pro Arg Ala Lys Gln Pro Thr 
            20                  25                  30          


Cys Thr Ala Trp Phe Pro Gln Gln Glu His Pro Ser Glu Asn Gly Pro 
        35                  40                  45              


Gln Met Pro Gly Arg Asp Pro Pro Ala Ala Ser Thr Met Gln Val Leu 
    50                  55                  60                  


Leu Leu Thr Ser Ala Glu Asp Leu Asp Cys Thr Pro Gly Phe Gln Gln 
65                  70                  75                  80  


Lys Val Phe His Ile Asn Gln Pro Ala Glu Phe Ile Glu Asp Gln Ser 
                85                  90                  95      


Ile Leu Asn Leu Thr Phe Ser Asp Cys Lys Gly Asn Asp Lys Leu Arg 
            100                 105                 110         


Tyr Glu Val Ser Ser Pro Tyr Phe Lys Val Asn Ser Asp Gly Gly Leu 
        115                 120                 125             


Val Ala Leu Arg Asn Ile Thr Ala Val Gly Lys Thr Leu Phe Val His 
    130                 135                 140                 


Ala Arg Thr Pro His Ala Glu Asp Met Ala Glu Leu Val Ile Val Gly 
145                 150                 155                 160 


Gly Lys Asp Ile Gln Gly Ser Leu Gln Asp Ile Phe Lys Phe Ala Arg 
                165                 170                 175     


Thr Ser Pro Val Pro Arg Gln Lys Arg Ser Ile Val Val Ser Pro Ile 
            180                 185                 190         


Leu Ile Pro Glu Asn Gln Arg Gln Pro Phe Pro Arg Asp Val Gly Lys 
        195                 200                 205             


Val Val Asp Ser Asp Arg Pro Glu Arg Ser Lys Phe Arg Leu Thr Gly 
    210                 215                 220                 


Lys Gly Val Asp Gln Glu Pro Lys Gly Ile Phe Arg Ile Asn Glu Asn 
225                 230                 235                 240 


Thr Gly Ser Val Ser Val Thr Arg Thr Leu Asp Arg Glu Val Ile Ala 
                245                 250                 255     


Val Tyr Gln Leu Phe Val Glu Thr Thr Asp Val Asn Gly Lys Thr Leu 
            260                 265                 270         


Glu Gly Pro Val Pro Leu Glu Val Ile Val Ile Asp Gln Asn Asp Asn 
        275                 280                 285             


Arg Pro Ile Phe Arg Glu Gly Pro Tyr Ile Gly His Val Met Glu Gly 
    290                 295                 300                 


Ser Pro Thr Gly Thr Thr Val Met Arg Met Thr Ala Phe Asp Ala Asp 
305                 310                 315                 320 


Asp Pro Ala Thr Asp Asn Ala Leu Leu Arg Tyr Asn Ile Arg Gln Gln 
                325                 330                 335     


Thr Pro Asp Lys Pro Ser Pro Asn Met Phe Tyr Ile Asp Pro Glu Lys 
            340                 345                 350         


Gly Asp Ile Val Thr Val Val Ser Pro Ala Leu Leu Asp Arg Glu Thr 
        355                 360                 365             


Leu Glu Asn Pro Lys Tyr Glu Leu Ile Ile Glu Ala Gln Asp Met Ala 
    370                 375                 380                 


Gly Leu Asp Val Gly Leu Thr Gly Thr Ala Thr Ala Thr Ile Met Ile 
385                 390                 395                 400 


Asp Asp Lys Asn Asp His Ser Pro Lys Phe Thr Lys Lys Glu Phe Gln 
                405                 410                 415     


Ala Thr Val Glu Glu Gly Ala Val Gly Val Ile Val Asn Leu Thr Val 
            420                 425                 430         


Glu Asp Lys Asp Asp Pro Thr Thr Gly Ala Trp Arg Ala Ala Tyr Thr 
        435                 440                 445             


Ile Ile Asn Gly Asn Pro Gly Gln Ser Phe Glu Ile His Thr Asn Pro 
    450                 455                 460                 


Gln Thr Asn Glu Gly Met Leu Ser Val Val Lys Pro Leu Asp Tyr Glu 
465                 470                 475                 480 


Ile Ser Ala Phe His Thr Leu Leu Ile Lys Val Glu Asn Glu Asp Pro 
                485                 490                 495     


Leu Val Pro Asp Val Ser Tyr Gly Pro Ser Ser Thr Ala Thr Val His 
            500                 505                 510         


Ile Thr Val Leu Asp Val Asn Glu Gly Pro Val Phe Tyr Pro Asp Pro 
        515                 520                 525             


Met Met Val Thr Arg Gln Glu Asp Leu Ser Val Gly Ser Val Leu Leu 
    530                 535                 540                 


Thr Val Asn Ala Thr Asp Pro Asp Ser Leu Gln His Gln Thr Ile Arg 
545                 550                 555                 560 


Tyr Ser Val Tyr Lys Asp Pro Ala Gly Trp Leu Asn Ile Asn Pro Ile 
                565                 570                 575     


Asn Gly Thr Val Asp Thr Thr Ala Val Leu Asp Arg Glu Ser Pro Phe 
            580                 585                 590         


Val Asp Asn Ser Val Tyr Thr Ala Leu Phe Leu Ala Ile Asp Ser Gly 
        595                 600                 605             


Asn Pro Pro Ala Thr Gly Thr Gly Thr Leu Leu Ile Thr Leu Glu Asp 
    610                 615                 620                 


Val Asn Asp Asn Ala Pro Phe Ile Tyr Pro Thr Val Ala Glu Val Cys 
625                 630                 635                 640 


Asp Asp Ala Lys Asn Leu Ser Val Val Ile Leu Gly Ala Ser Asp Lys 
                645                 650                 655     


Asp Leu His Pro Asn Thr Asp Pro Phe Lys Phe Glu Ile His Lys Gln 
            660                 665                 670         


Ala Val Pro Asp Lys Val Trp Lys Ile Ser Lys Ile Asn Asn Thr His 
        675                 680                 685             


Ala Leu Val Ser Leu Leu Gln Asn Leu Asn Lys Ala Asn Tyr Asn Leu 
    690                 695                 700                 


Pro Ile Met Val Thr Asp Ser Gly Lys Pro Pro Met Thr Asn Ile Thr 
705                 710                 715                 720 


Asp Leu Arg Val Gln Val Cys Ser Cys Arg Asn Ser Lys Val Asp Cys 
                725                 730                 735     


Asn Ala Ala Gly Ala Leu Arg Phe Ser Leu Pro Ser Val Leu Leu Leu 
            740                 745                 750         


Ser Leu Phe Ser Leu Ala Cys Leu 
        755                 760 


<210>  2483
<211>  37
<212>  PRT
<213>  Homo Sapiens

<400>  2483

Met Gln Pro Arg Thr Pro Leu Val Leu Cys Val Leu Leu Ser Gln Ser 
1               5                   10                  15      


Gly Gly Pro Val Cys Lys Ser Gln Phe Gln Ala Leu Pro Leu Ala Val 
            20                  25                  30          


Gln Trp Leu Gly Val 
        35          


<210>  2484
<211>  67
<212>  PRT
<213>  Homo Sapiens

<400>  2484

Met Gln Pro Arg Thr Pro Leu Val Leu Cys Val Leu Leu Ser Gln Thr 
1               5                   10                  15      


Pro Val Arg Pro Thr Ile Tyr Leu Cys Gln Asn Leu Gln Phe Ile Lys 
            20                  25                  30          


Asn Lys Ala Arg Asp Ser Asn Ser Leu Ala Asp His Lys Gly Lys Arg 
        35                  40                  45              


Ile Gln Val Asn Arg Leu Leu Pro Gly Leu Leu Phe His Asp Glu Leu 
    50                  55                  60                  


Ser Gly Ile 
65          


<210>  2485
<211>  52
<212>  PRT
<213>  Homo Sapiens

<400>  2485

Met Gln Pro Arg Thr Pro Leu Val Leu Cys Val Leu Leu Ser Gln Val 
1               5                   10                  15      


Leu Leu Leu Thr Ser Ala Glu Asp Leu Asp Cys Thr Pro Gly Phe Gln 
            20                  25                  30          


Gln Lys Val Phe His Ile Asn Gln Pro Ala Glu Phe Ile Glu Asp Gln 
        35                  40                  45              


Ser Ile Leu Asn 
    50          


<210>  2486
<211>  67
<212>  PRT
<213>  Homo Sapiens

<400>  2486

Met Gln Pro Arg Thr Pro Leu Val Leu Cys Val Leu Leu Ser Gln Val 
1               5                   10                  15      


Leu Leu Leu Thr Ser Ala Glu Asp Leu Asp Cys Thr Pro Gly Phe Gln 
            20                  25                  30          


Gln Lys Val Phe His Ile Asn Gln Pro Ala Glu Phe Ile Glu Asp Gln 
        35                  40                  45              


Ser Ile Leu Asn Cys Lys Gln Cys His Ser Lys Met Leu Leu Asp Ser 
    50                  55                  60                  


Ser His Ile 
65          


<210>  2487
<211>  175
<212>  PRT
<213>  Homo Sapiens

<400>  2487

Met Gln Pro Arg Thr Pro Leu Val Leu Cys Val Leu Leu Ser Gln Val 
1               5                   10                  15      


Leu Leu Leu Thr Ser Ala Glu Asp Leu Asp Cys Thr Pro Gly Phe Gln 
            20                  25                  30          


Gln Lys Val Phe His Ile Asn Gln Pro Ala Glu Phe Ile Glu Asp Gln 
        35                  40                  45              


Ser Ile Leu Asn Leu Thr Phe Ser Asp Cys Lys Gly Asn Asp Lys Leu 
    50                  55                  60                  


Arg Tyr Glu Val Ser Ser Pro Tyr Phe Lys Val Asn Ser Asp Gly Gly 
65                  70                  75                  80  


Leu Val Ala Leu Arg Asn Ile Thr Ala Val Gly Lys Thr Leu Phe Val 
                85                  90                  95      


His Ala Arg Thr Pro His Ala Glu Asp Met Ala Glu Leu Val Ile Val 
            100                 105                 110         


Gly Gly Lys Asp Ile Gln Gly Ser Leu Gln Asp Ile Phe Lys Phe Ala 
        115                 120                 125             


Arg Thr Ser Pro Val Pro Arg Gln Lys Arg Ser Ile Val Val Ser Pro 
    130                 135                 140                 


Ile Leu Ile Pro Glu Asn Gln Arg Gln Pro Phe Pro Arg Asp Val Gly 
145                 150                 155                 160 


Lys Met Lys Ile Trp Gln Val Leu Cys Leu Ala Arg Trp Leu Thr 
                165                 170                 175 


<210>  2488
<211>  190
<212>  PRT
<213>  Homo Sapiens

<400>  2488

Met Gln Pro Arg Thr Pro Leu Val Leu Cys Val Leu Leu Ser Gln Val 
1               5                   10                  15      


Leu Leu Leu Thr Ser Ala Glu Asp Leu Asp Cys Thr Pro Gly Phe Gln 
            20                  25                  30          


Gln Lys Val Phe His Ile Asn Gln Pro Ala Glu Phe Ile Glu Asp Gln 
        35                  40                  45              


Ser Ile Leu Asn Leu Thr Phe Ser Asp Cys Lys Gly Asn Asp Lys Leu 
    50                  55                  60                  


Arg Tyr Glu Val Ser Ser Pro Tyr Phe Lys Val Asn Ser Asp Gly Gly 
65                  70                  75                  80  


Leu Val Ala Leu Arg Asn Ile Thr Ala Val Gly Lys Thr Leu Phe Val 
                85                  90                  95      


His Ala Arg Thr Pro His Ala Glu Asp Met Ala Glu Leu Val Ile Val 
            100                 105                 110         


Gly Gly Lys Asp Ile Gln Gly Ser Leu Gln Asp Ile Phe Lys Phe Ala 
        115                 120                 125             


Arg Thr Ser Pro Val Pro Arg Gln Lys Arg Ser Ile Val Val Ser Pro 
    130                 135                 140                 


Ile Leu Ile Pro Glu Asn Gln Arg Gln Pro Phe Pro Arg Asp Val Gly 
145                 150                 155                 160 


Lys Arg Thr His Asn Pro Ile Asn Ser Glu Leu Leu Leu Asn Glu Gly 
                165                 170                 175     


Ile Thr Ala Asp Leu Asn Pro Cys Ile Thr Ile Leu Ala Ile 
            180                 185                 190 


<210>  2489
<211>  713
<212>  PRT
<213>  Homo Sapiens

<400>  2489

Met Gln Pro Arg Thr Pro Leu Val Leu Cys Val Leu Leu Ser Gln Val 
1               5                   10                  15      


Leu Leu Leu Thr Ser Ala Glu Asp Leu Asp Cys Thr Pro Gly Phe Gln 
            20                  25                  30          


Gln Lys Val Phe His Ile Asn Gln Pro Ala Glu Phe Ile Glu Asp Gln 
        35                  40                  45              


Ser Ile Leu Asn Leu Thr Phe Ser Asp Cys Lys Gly Asn Asp Lys Leu 
    50                  55                  60                  


Arg Tyr Glu Val Ser Ser Pro Tyr Phe Lys Val Asn Ser Asp Gly Gly 
65                  70                  75                  80  


Leu Val Ala Leu Arg Asn Ile Thr Ala Val Gly Lys Thr Leu Phe Val 
                85                  90                  95      


His Ala Arg Thr Pro His Ala Glu Asp Met Ala Glu Leu Val Ile Val 
            100                 105                 110         


Gly Gly Lys Asp Ile Gln Gly Ser Leu Gln Asp Ile Phe Lys Phe Ala 
        115                 120                 125             


Arg Thr Ser Pro Val Pro Arg Gln Lys Arg Ser Ile Val Val Ser Pro 
    130                 135                 140                 


Ile Leu Ile Pro Glu Asn Gln Arg Gln Pro Phe Pro Arg Asp Val Gly 
145                 150                 155                 160 


Lys Val Val Asp Ser Asp Arg Pro Glu Arg Ser Lys Phe Arg Leu Thr 
                165                 170                 175     


Gly Lys Gly Val Asp Gln Glu Pro Lys Gly Ile Phe Arg Ile Asn Glu 
            180                 185                 190         


Asn Thr Gly Ser Val Ser Val Thr Arg Thr Leu Asp Arg Glu Val Ile 
        195                 200                 205             


Ala Val Tyr Gln Leu Phe Val Glu Thr Thr Asp Val Asn Gly Lys Thr 
    210                 215                 220                 


Leu Glu Gly Pro Val Pro Leu Glu Val Ile Val Ile Asp Gln Asn Asp 
225                 230                 235                 240 


Asn Arg Pro Ile Phe Arg Glu Gly Pro Tyr Ile Gly His Val Met Glu 
                245                 250                 255     


Gly Ser Pro Thr Gly Thr Thr Val Met Arg Met Thr Ala Phe Asp Ala 
            260                 265                 270         


Asp Asp Pro Ala Thr Asp Asn Ala Leu Leu Arg Tyr Asn Ile Arg Gln 
        275                 280                 285             


Gln Thr Pro Asp Lys Pro Ser Pro Asn Met Phe Tyr Ile Asp Pro Glu 
    290                 295                 300                 


Lys Gly Asp Ile Val Thr Val Val Ser Pro Ala Leu Leu Asp Arg Glu 
305                 310                 315                 320 


Thr Leu Glu Asn Pro Lys Tyr Glu Leu Ile Ile Glu Ala Gln Asp Met 
                325                 330                 335     


Ala Gly Leu Asp Val Gly Leu Thr Gly Thr Ala Thr Ala Thr Ile Met 
            340                 345                 350         


Ile Asp Asp Lys Asn Asp His Ser Pro Lys Phe Thr Lys Lys Glu Phe 
        355                 360                 365             


Gln Ala Thr Val Glu Glu Gly Ala Val Gly Val Ile Val Asn Leu Thr 
    370                 375                 380                 


Val Glu Asp Lys Asp Asp Pro Thr Thr Gly Ala Trp Arg Ala Ala Tyr 
385                 390                 395                 400 


Thr Ile Ile Asn Gly Asn Pro Gly Gln Ser Phe Glu Ile His Thr Asn 
                405                 410                 415     


Pro Gln Thr Asn Glu Gly Met Leu Ser Val Val Lys Pro Leu Asp Tyr 
            420                 425                 430         


Glu Ile Ser Ala Phe His Thr Leu Leu Ile Lys Val Glu Asn Glu Asp 
        435                 440                 445             


Pro Leu Val Pro Asp Val Ser Tyr Gly Pro Ser Ser Thr Ala Thr Val 
    450                 455                 460                 


His Ile Thr Val Leu Asp Val Asn Glu Gly Pro Val Phe Tyr Pro Asp 
465                 470                 475                 480 


Pro Met Met Val Thr Arg Gln Glu Asp Leu Ser Val Gly Ser Val Leu 
                485                 490                 495     


Leu Thr Val Asn Ala Thr Asp Pro Asp Ser Leu Gln His Gln Thr Ile 
            500                 505                 510         


Arg Tyr Ser Val Tyr Lys Asp Pro Ala Gly Trp Leu Asn Ile Asn Pro 
        515                 520                 525             


Ile Asn Gly Thr Val Asp Thr Thr Ala Val Leu Asp Arg Glu Ser Pro 
    530                 535                 540                 


Phe Val Asp Asn Ser Val Tyr Thr Ala Leu Phe Leu Ala Ile Asp Ser 
545                 550                 555                 560 


Gly Asn Pro Pro Ala Thr Gly Thr Gly Thr Leu Leu Ile Thr Leu Glu 
                565                 570                 575     


Asp Val Asn Asp Asn Ala Pro Phe Ile Tyr Pro Thr Val Ala Glu Val 
            580                 585                 590         


Cys Asp Asp Ala Lys Asn Leu Ser Val Val Ile Leu Gly Ala Ser Asp 
        595                 600                 605             


Lys Asp Leu His Pro Asn Thr Asp Pro Phe Lys Phe Glu Ile His Lys 
    610                 615                 620                 


Gln Ala Val Pro Asp Lys Val Trp Lys Ile Ser Lys Ile Asn Asn Thr 
625                 630                 635                 640 


His Ala Leu Val Ser Leu Leu Gln Asn Leu Asn Lys Ala Asn Tyr Asn 
                645                 650                 655     


Leu Pro Ile Met Val Thr Asp Ser Gly Lys Pro Pro Met Thr Asn Ile 
            660                 665                 670         


Thr Asp Leu Arg Val Gln Val Cys Ser Cys Arg Asn Ser Lys Val Asp 
        675                 680                 685             


Cys Asn Ala Ala Gly Ala Leu Arg Phe Ser Leu Pro Ser Val Leu Leu 
    690                 695                 700                 


Leu Ser Leu Phe Ser Leu Ala Cys Leu 
705                 710             


<210>  2490
<211>  674
<212>  PRT
<213>  Homo Sapiens

<400>  2490

Met Gln Pro Arg Thr Pro Leu Val Leu Cys Val Leu Leu Ser Gln Val 
1               5                   10                  15      


Leu Leu Leu Thr Ser Ala Glu Asp Leu Asp Cys Thr Pro Gly Phe Gln 
            20                  25                  30          


Gln Lys Val Phe His Ile Asn Gln Pro Ala Glu Phe Ile Glu Asp Gln 
        35                  40                  45              


Ser Ile Leu Asn Leu Thr Phe Ser Asp Cys Lys Gly Asn Asp Lys Leu 
    50                  55                  60                  


Arg Tyr Glu Val Ser Ser Pro Tyr Phe Lys Val Asn Ser Asp Gly Gly 
65                  70                  75                  80  


Leu Val Ala Leu Arg Asn Ile Thr Ala Val Gly Lys Thr Leu Phe Val 
                85                  90                  95      


His Ala Arg Thr Pro His Ala Glu Asp Met Ala Glu Leu Val Ile Val 
            100                 105                 110         


Gly Gly Lys Asp Ile Gln Gly Ser Leu Gln Val Val Asp Ser Asp Arg 
        115                 120                 125             


Pro Glu Arg Ser Lys Phe Arg Leu Thr Gly Lys Gly Val Asp Gln Glu 
    130                 135                 140                 


Pro Lys Gly Ile Phe Arg Ile Asn Glu Asn Thr Gly Ser Val Ser Val 
145                 150                 155                 160 


Thr Arg Thr Leu Asp Arg Glu Val Ile Ala Val Tyr Gln Leu Phe Val 
                165                 170                 175     


Glu Thr Thr Asp Val Asn Gly Lys Thr Leu Glu Gly Pro Val Pro Leu 
            180                 185                 190         


Glu Val Ile Val Ile Asp Gln Asn Asp Asn Arg Pro Ile Phe Arg Glu 
        195                 200                 205             


Gly Pro Tyr Ile Gly His Val Met Glu Gly Ser Pro Thr Gly Thr Thr 
    210                 215                 220                 


Val Met Arg Met Thr Ala Phe Asp Ala Asp Asp Pro Ala Thr Asp Asn 
225                 230                 235                 240 


Ala Leu Leu Arg Tyr Asn Ile Arg Gln Gln Thr Pro Asp Lys Pro Ser 
                245                 250                 255     


Pro Asn Met Phe Tyr Ile Asp Pro Glu Lys Gly Asp Ile Val Thr Val 
            260                 265                 270         


Val Ser Pro Ala Leu Leu Asp Arg Glu Thr Leu Glu Asn Pro Lys Tyr 
        275                 280                 285             


Glu Leu Ile Ile Glu Ala Gln Asp Met Ala Gly Leu Asp Val Gly Leu 
    290                 295                 300                 


Thr Gly Thr Ala Thr Ala Thr Ile Met Ile Asp Asp Lys Asn Asp His 
305                 310                 315                 320 


Ser Pro Lys Phe Thr Lys Lys Glu Phe Gln Ala Thr Val Glu Glu Gly 
                325                 330                 335     


Ala Val Gly Val Ile Val Asn Leu Thr Val Glu Asp Lys Asp Asp Pro 
            340                 345                 350         


Thr Thr Gly Ala Trp Arg Ala Ala Tyr Thr Ile Ile Asn Gly Asn Pro 
        355                 360                 365             


Gly Gln Ser Phe Glu Ile His Thr Asn Pro Gln Thr Asn Glu Gly Met 
    370                 375                 380                 


Leu Ser Val Val Lys Pro Leu Asp Tyr Glu Ile Ser Ala Phe His Thr 
385                 390                 395                 400 


Leu Leu Ile Lys Val Glu Asn Glu Asp Pro Leu Val Pro Asp Val Ser 
                405                 410                 415     


Tyr Gly Pro Ser Ser Thr Ala Thr Val His Ile Thr Val Leu Asp Val 
            420                 425                 430         


Asn Glu Gly Pro Val Phe Tyr Pro Asp Pro Met Met Val Thr Arg Gln 
        435                 440                 445             


Glu Asp Leu Ser Val Gly Ser Val Leu Leu Thr Val Asn Ala Thr Asp 
    450                 455                 460                 


Pro Asp Ser Leu Gln His Gln Thr Ile Arg Tyr Ser Val Tyr Lys Asp 
465                 470                 475                 480 


Pro Ala Gly Trp Leu Asn Ile Asn Pro Ile Asn Gly Thr Val Asp Thr 
                485                 490                 495     


Thr Ala Val Leu Asp Arg Glu Ser Pro Phe Val Asp Asn Ser Val Tyr 
            500                 505                 510         


Thr Ala Leu Phe Leu Ala Ile Asp Ser Gly Asn Pro Pro Ala Thr Gly 
        515                 520                 525             


Thr Gly Thr Leu Leu Ile Thr Leu Glu Asp Val Asn Asp Asn Ala Pro 
    530                 535                 540                 


Phe Ile Tyr Pro Thr Val Ala Glu Val Cys Asp Asp Ala Lys Asn Leu 
545                 550                 555                 560 


Ser Val Val Ile Leu Gly Ala Ser Asp Lys Asp Leu His Pro Asn Thr 
                565                 570                 575     


Asp Pro Phe Lys Phe Glu Ile His Lys Gln Ala Val Pro Asp Lys Val 
            580                 585                 590         


Trp Lys Ile Ser Lys Ile Asn Asn Thr His Ala Leu Val Ser Leu Leu 
        595                 600                 605             


Gln Asn Leu Asn Lys Ala Asn Tyr Asn Leu Pro Ile Met Val Thr Asp 
    610                 615                 620                 


Ser Gly Lys Pro Pro Met Thr Asn Ile Thr Asp Leu Arg Val Gln Val 
625                 630                 635                 640 


Cys Ser Cys Arg Asn Ser Lys Val Asp Cys Asn Ala Ala Gly Ala Leu 
                645                 650                 655     


Arg Phe Ser Leu Pro Ser Val Leu Leu Leu Ser Leu Phe Ser Leu Ala 
            660                 665                 670         


Cys Leu 
        


<210>  2491
<211>  56
<212>  PRT
<213>  Homo Sapiens

<400>  2491

Met Gln Pro Arg Thr Pro Leu Val Leu Cys Val Leu Leu Ser Gln Val 
1               5                   10                  15      


Leu Leu Leu Thr Ser Ala Glu Asp Leu Asp Cys Thr Pro Gly Phe Gln 
            20                  25                  30          


Gln Lys Val Phe His Ile Asn Gln Pro Ala Glu Phe Ile Glu Asp Gln 
        35                  40                  45              


Ser Ile Leu Asn Tyr Val Phe Tyr 
    50                  55      


<210>  2492
<211>  147
<212>  PRT
<213>  Homo Sapiens

<400>  2492

Met Ile Leu Gln Ala His Leu His Ser Leu Cys Leu Leu Met Leu Tyr 
1               5                   10                  15      


Leu Ala Thr Gly Tyr Gly Gln Glu Gly Lys Phe Ser Gly Pro Leu Lys 
            20                  25                  30          


Pro Met Thr Phe Ser Ile Tyr Glu Gly Gln Glu Pro Ser Gln Ile Ile 
        35                  40                  45              


Phe Gln Phe Lys Ala Asn Pro Pro Ala Val Thr Phe Glu Leu Thr Gly 
    50                  55                  60                  


Glu Thr Asp Asn Ile Phe Val Ile Glu Arg Glu Gly Leu Leu Tyr Tyr 
65                  70                  75                  80  


Asn Arg Ala Leu Asp Arg Glu Thr Arg Ser Thr His Asn Leu Gln Val 
                85                  90                  95      


Ala Ala Leu Asp Ala Asn Gly Ile Ile Val Glu Gly Pro Val Pro Ile 
            100                 105                 110         


Thr Ile Lys Val Lys Asp Ile Asn Asp Asn Arg Pro Thr Phe Leu Gln 
        115                 120                 125             


Ser Lys Tyr Glu Gly Ser Val Arg Gln Asn Ser Arg Pro Gly Lys Pro 
    130                 135                 140                 


Phe Leu Tyr 
145         


<210>  2493
<211>  832
<212>  PRT
<213>  Homo Sapiens

<400>  2493

Met Ile Leu Gln Ala His Leu His Ser Leu Cys Leu Leu Met Leu Tyr 
1               5                   10                  15      


Leu Ala Thr Gly Tyr Gly Gln Glu Gly Lys Phe Ser Gly Pro Leu Lys 
            20                  25                  30          


Pro Met Thr Phe Ser Ile Tyr Glu Gly Gln Glu Pro Ser Gln Ile Ile 
        35                  40                  45              


Phe Gln Phe Lys Ala Asn Pro Pro Ala Val Thr Phe Glu Leu Thr Gly 
    50                  55                  60                  


Glu Thr Asp Asn Ile Phe Val Ile Glu Arg Glu Gly Leu Leu Tyr Tyr 
65                  70                  75                  80  


Asn Arg Ala Leu Asp Arg Glu Thr Arg Ser Thr His Asn Leu Gln Val 
                85                  90                  95      


Ala Ala Leu Asp Ala Asn Gly Ile Ile Val Glu Gly Pro Val Pro Ile 
            100                 105                 110         


Thr Ile Lys Val Lys Asp Ile Asn Asp Asn Arg Pro Thr Phe Leu Gln 
        115                 120                 125             


Ser Lys Tyr Glu Gly Ser Val Arg Gln Asn Ser Arg Pro Gly Lys Pro 
    130                 135                 140                 


Phe Leu Tyr Val Asn Ala Thr Asp Leu Asp Asp Pro Ala Thr Pro Asn 
145                 150                 155                 160 


Gly Gln Leu Tyr Tyr Gln Ile Val Ile Gln Leu Pro Met Ile Asn Asn 
                165                 170                 175     


Val Met Tyr Phe Gln Ile Asn Asn Lys Thr Gly Ala Ile Ser Leu Thr 
            180                 185                 190         


Arg Glu Gly Ser Gln Glu Leu Asn Pro Ala Lys Asn Pro Ser Tyr Asn 
        195                 200                 205             


Leu Val Ile Ser Val Lys Asp Met Gly Gly Gln Ser Glu Asn Ser Phe 
    210                 215                 220                 


Ser Asp Thr Thr Ser Val Asp Ile Ile Val Thr Glu Asn Ile Trp Lys 
225                 230                 235                 240 


Ala Pro Lys Pro Val Glu Met Val Glu Asn Ser Thr Asp Pro His Pro 
                245                 250                 255     


Ile Lys Ile Thr Gln Val Arg Trp Asn Asp Pro Gly Ala Gln Tyr Ser 
            260                 265                 270         


Leu Val Asp Lys Glu Lys Leu Pro Arg Phe Pro Phe Ser Ile Asp Gln 
        275                 280                 285             


Glu Gly Asp Ile Tyr Val Thr Gln Pro Leu Asp Arg Glu Glu Lys Asp 
    290                 295                 300                 


Ala Tyr Val Phe Tyr Ala Val Ala Lys Asp Glu Tyr Gly Lys Pro Leu 
305                 310                 315                 320 


Ser Tyr Pro Leu Glu Ile His Val Lys Val Lys Asp Ile Asn Asp Asn 
                325                 330                 335     


Pro Pro Thr Cys Pro Ser Pro Val Thr Val Phe Glu Val Gln Glu Asn 
            340                 345                 350         


Glu Arg Leu Gly Asn Ser Ile Gly Thr Leu Thr Ala His Asp Arg Asp 
        355                 360                 365             


Glu Glu Asn Thr Ala Asn Ser Phe Leu Asn Tyr Arg Ile Val Glu Gln 
    370                 375                 380                 


Thr Pro Lys Leu Pro Met Asp Gly Leu Phe Leu Ile Gln Thr Tyr Ala 
385                 390                 395                 400 


Gly Met Leu Gln Leu Ala Lys Gln Ser Leu Lys Lys Gln Asp Thr Pro 
                405                 410                 415     


Gln Tyr Asn Leu Thr Ile Glu Val Ser Asp Lys Asp Phe Lys Thr Leu 
            420                 425                 430         


Cys Phe Val Gln Ile Asn Val Ile Asp Ile Asn Asp Gln Ile Pro Ile 
        435                 440                 445             


Phe Glu Lys Ser Asp Tyr Gly Asn Leu Thr Leu Ala Glu Asp Thr Asn 
    450                 455                 460                 


Ile Gly Ser Thr Ile Leu Thr Ile Gln Ala Thr Asp Ala Asp Glu Pro 
465                 470                 475                 480 


Phe Thr Gly Ser Ser Lys Ile Leu Tyr His Ile Ile Lys Gly Asp Ser 
                485                 490                 495     


Glu Gly Arg Leu Gly Val Asp Thr Asp Pro His Thr Asn Thr Gly Tyr 
            500                 505                 510         


Val Ile Ile Lys Lys Pro Leu Asp Phe Glu Thr Ala Ala Val Ser Asn 
        515                 520                 525             


Ile Val Phe Lys Ala Glu Asn Pro Glu Pro Leu Val Phe Gly Val Lys 
    530                 535                 540                 


Tyr Asn Ala Ser Ser Phe Ala Lys Phe Thr Leu Ile Val Thr Asp Val 
545                 550                 555                 560 


Asn Glu Ala Pro Gln Phe Ser Gln His Val Phe Gln Ala Lys Val Ser 
                565                 570                 575     


Glu Asp Val Ala Ile Gly Thr Lys Val Gly Asn Val Thr Ala Lys Asp 
            580                 585                 590         


Pro Glu Gly Leu Asp Ile Ser Tyr Ser Leu Arg Gly Asp Thr Arg Gly 
        595                 600                 605             


Trp Leu Lys Ile Asp His Val Thr Gly Glu Ile Phe Ser Val Ala Pro 
    610                 615                 620                 


Leu Asp Arg Glu Ala Gly Ser Pro Tyr Arg Val Gln Val Val Ala Thr 
625                 630                 635                 640 


Glu Val Gly Gly Ser Ser Leu Ser Ser Val Ser Glu Phe His Leu Ile 
                645                 650                 655     


Leu Met Asp Val Asn Asp Asn Pro Pro Arg Leu Ala Lys Asp Tyr Thr 
            660                 665                 670         


Gly Leu Phe Phe Cys His Pro Leu Ser Ala Pro Gly Ser Leu Ile Phe 
        675                 680                 685             


Glu Ala Thr Asp Asp Asp Gln His Leu Phe Arg Gly Pro His Phe Thr 
    690                 695                 700                 


Phe Ser Leu Gly Ser Gly Ser Leu Gln Asn Asp Trp Glu Val Ser Lys 
705                 710                 715                 720 


Ile Asn Gly Thr His Ala Arg Leu Ser Thr Arg His Thr Glu Phe Glu 
                725                 730                 735     


Glu Arg Glu Tyr Val Val Leu Ile Arg Ile Asn Asp Gly Gly Arg Pro 
            740                 745                 750         


Pro Leu Glu Gly Ile Val Ser Leu Pro Val Thr Phe Cys Ser Cys Val 
        755                 760                 765             


Glu Gly Ser Cys Phe Arg Pro Ala Gly His Gln Thr Gly Ile Pro Thr 
    770                 775                 780                 


Val Gly Met Ala Val Gly Ile Leu Leu Thr Thr Leu Leu Val Ile Gly 
785                 790                 795                 800 


Ile Ile Leu Ala Val Val Phe Ile Arg Ile Lys Lys Asp Lys Gly Lys 
                805                 810                 815     


Asp Asn Val Glu Ser Ala Gln Ala Ser Glu Val Lys Pro Leu Arg Ser 
            820                 825                 830         


<210>  2494
<211>  832
<212>  PRT
<213>  Homo Sapiens

<400>  2494

Met Ile Leu Gln Ala His Leu His Ser Leu Cys Leu Leu Met Leu Tyr 
1               5                   10                  15      


Leu Ala Thr Gly Tyr Gly Gln Glu Gly Lys Phe Ser Gly Pro Leu Lys 
            20                  25                  30          


Pro Met Thr Phe Ser Ile Tyr Glu Gly Gln Glu Pro Ser Gln Ile Ile 
        35                  40                  45              


Phe Gln Phe Lys Ala Asn Pro Pro Ala Val Thr Phe Glu Leu Thr Gly 
    50                  55                  60                  


Glu Thr Asp Asn Ile Phe Val Ile Glu Arg Glu Gly Leu Leu Tyr Tyr 
65                  70                  75                  80  


Asn Arg Ala Leu Asp Arg Glu Thr Arg Ser Thr His Asn Leu Gln Val 
                85                  90                  95      


Ala Ala Leu Asp Ala Asn Gly Ile Ile Val Glu Gly Pro Val Pro Ile 
            100                 105                 110         


Thr Ile Lys Val Lys Asp Ile Asn Asp Asn Arg Pro Thr Phe Leu Gln 
        115                 120                 125             


Ser Lys Tyr Glu Gly Ser Val Arg Gln Asn Ser Arg Pro Gly Lys Pro 
    130                 135                 140                 


Phe Leu Tyr Val Asn Ala Thr Asp Leu Asp Asp Pro Ala Thr Pro Asn 
145                 150                 155                 160 


Gly Gln Leu Tyr Tyr Gln Ile Val Ile Gln Leu Pro Met Ile Asn Asn 
                165                 170                 175     


Val Met Tyr Phe Gln Ile Asn Asn Lys Thr Gly Ala Ile Ser Leu Thr 
            180                 185                 190         


Arg Glu Gly Ser Gln Glu Leu Asn Pro Ala Lys Asn Pro Ser Tyr Asn 
        195                 200                 205             


Leu Val Ile Ser Val Lys Asp Met Gly Gly Gln Ser Glu Asn Ser Phe 
    210                 215                 220                 


Ser Asp Thr Thr Ser Val Asp Ile Ile Val Thr Glu Asn Ile Trp Lys 
225                 230                 235                 240 


Ala Pro Lys Pro Val Glu Met Val Glu Asn Ser Thr Asp Pro His Pro 
                245                 250                 255     


Ile Lys Ile Thr Gln Val Arg Trp Asn Asp Pro Gly Ala Gln Tyr Ser 
            260                 265                 270         


Leu Val Asp Lys Glu Lys Leu Pro Arg Phe Pro Phe Ser Ile Asp Gln 
        275                 280                 285             


Glu Gly Asp Ile Tyr Val Thr Gln Pro Leu Asp Arg Glu Glu Lys Asp 
    290                 295                 300                 


Ala Tyr Val Phe Tyr Ala Val Ala Lys Asp Glu Tyr Gly Lys Pro Leu 
305                 310                 315                 320 


Ser Tyr Pro Leu Glu Ile His Val Lys Val Lys Asp Ile Asn Asp Asn 
                325                 330                 335     


Pro Pro Thr Cys Pro Ser Pro Val Thr Val Phe Glu Val Gln Glu Asn 
            340                 345                 350         


Glu Arg Leu Gly Asn Ser Ile Gly Thr Leu Thr Ala His Asp Arg Asp 
        355                 360                 365             


Glu Glu Asn Thr Ala Asn Ser Phe Leu Asn Tyr Arg Ile Val Glu Gln 
    370                 375                 380                 


Thr Pro Lys Leu Pro Met Asp Gly Leu Phe Leu Ile Gln Thr Tyr Ala 
385                 390                 395                 400 


Gly Met Leu Gln Leu Ala Lys Gln Ser Leu Lys Lys Gln Asp Thr Pro 
                405                 410                 415     


Gln Tyr Asn Leu Thr Ile Glu Val Ser Asp Lys Asp Phe Lys Thr Leu 
            420                 425                 430         


Cys Phe Val Gln Ile Asn Val Ile Asp Ile Asn Asp Gln Ile Pro Ile 
        435                 440                 445             


Phe Glu Lys Ser Asp Tyr Gly Asn Leu Thr Leu Ala Glu Asp Thr Asn 
    450                 455                 460                 


Ile Gly Ser Thr Ile Leu Thr Ile Gln Ala Thr Asp Ala Asp Glu Pro 
465                 470                 475                 480 


Phe Thr Gly Ser Ser Lys Ile Leu Tyr His Ile Ile Lys Gly Asp Ser 
                485                 490                 495     


Glu Gly Arg Leu Gly Val Asp Thr Asp Pro His Thr Asn Thr Gly Tyr 
            500                 505                 510         


Val Ile Ile Lys Lys Pro Leu Asp Phe Glu Thr Ala Ala Val Ser Asn 
        515                 520                 525             


Ile Val Phe Lys Ala Glu Asn Pro Glu Pro Leu Val Phe Gly Val Lys 
    530                 535                 540                 


Tyr Asn Ala Ser Ser Phe Ala Lys Phe Thr Leu Ile Val Thr Asp Val 
545                 550                 555                 560 


Asn Glu Ala Pro Gln Phe Ser Gln His Val Phe Gln Ala Lys Val Ser 
                565                 570                 575     


Glu Asp Val Ala Ile Gly Thr Lys Val Gly Asn Val Thr Ala Lys Asp 
            580                 585                 590         


Pro Glu Gly Leu Asp Ile Ser Tyr Ser Leu Arg Gly Asp Thr Arg Gly 
        595                 600                 605             


Trp Leu Lys Ile Asp His Val Thr Gly Glu Ile Phe Ser Val Ala Pro 
    610                 615                 620                 


Leu Asp Arg Glu Ala Gly Ser Pro Tyr Arg Val Gln Val Val Ala Thr 
625                 630                 635                 640 


Glu Val Gly Gly Ser Ser Leu Ser Ser Val Ser Glu Phe His Leu Ile 
                645                 650                 655     


Leu Met Asp Val Asn Asp Asn Pro Pro Arg Leu Ala Lys Asp Tyr Thr 
            660                 665                 670         


Gly Leu Phe Phe Cys His Pro Leu Ser Ala Pro Gly Ser Leu Ile Phe 
        675                 680                 685             


Glu Ala Thr Asp Asp Asp Gln His Leu Phe Arg Gly Pro His Phe Thr 
    690                 695                 700                 


Phe Ser Leu Gly Ser Gly Ser Leu Gln Asn Asp Trp Glu Val Ser Lys 
705                 710                 715                 720 


Ile Asn Gly Thr His Ala Arg Leu Ser Thr Arg His Thr Glu Phe Glu 
                725                 730                 735     


Glu Arg Glu Tyr Val Val Leu Ile Arg Ile Asn Asp Gly Gly Arg Pro 
            740                 745                 750         


Pro Leu Glu Gly Ile Val Ser Leu Pro Val Thr Phe Cys Ser Cys Val 
        755                 760                 765             


Glu Gly Ser Cys Phe Arg Pro Ala Gly His Gln Thr Gly Ile Pro Thr 
    770                 775                 780                 


Val Gly Met Ala Val Gly Ile Leu Leu Thr Thr Leu Leu Val Ile Gly 
785                 790                 795                 800 


Ile Ile Leu Ala Val Val Phe Ile Arg Ile Lys Lys Asp Lys Gly Lys 
                805                 810                 815     


Asp Asn Val Glu Ser Ala Gln Ala Ser Glu Val Lys Pro Leu Arg Ser 
            820                 825                 830         


<210>  2495
<211>  580
<212>  PRT
<213>  Homo Sapiens

<400>  2495

Met Ile Leu Gln Ala His Leu His Ser Leu Cys Leu Leu Met Leu Tyr 
1               5                   10                  15      


Leu Ala Thr Gly Tyr Gly Gln Glu Gly Lys Phe Ser Gly Pro Leu Lys 
            20                  25                  30          


Pro Met Thr Phe Ser Ile Tyr Glu Gly Gln Glu Pro Ser Gln Ile Ile 
        35                  40                  45              


Phe Gln Phe Lys Ala Asn Pro Pro Ala Val Thr Phe Glu Leu Thr Gly 
    50                  55                  60                  


Glu Thr Asp Asn Ile Phe Val Ile Glu Arg Glu Gly Leu Leu Tyr Tyr 
65                  70                  75                  80  


Asn Arg Ala Leu Asp Arg Glu Thr Arg Ser Thr His Asn Leu Gln Val 
                85                  90                  95      


Ala Ala Leu Asp Ala Asn Gly Ile Ile Val Glu Gly Pro Val Pro Ile 
            100                 105                 110         


Thr Ile Lys Val Lys Asp Ile Asn Asp Asn Arg Pro Thr Phe Leu Gln 
        115                 120                 125             


Ser Lys Tyr Glu Gly Ser Val Arg Gln Asn Ser Arg Pro Gly Asn Ser 
    130                 135                 140                 


Ile Gly Thr Leu Thr Ala His Asp Arg Asp Glu Glu Asn Thr Ala Asn 
145                 150                 155                 160 


Ser Phe Leu Asn Tyr Arg Ile Val Glu Gln Thr Pro Lys Leu Pro Met 
                165                 170                 175     


Asp Gly Leu Phe Leu Ile Gln Thr Tyr Ala Gly Met Leu Gln Leu Ala 
            180                 185                 190         


Lys Gln Ser Leu Lys Lys Gln Asp Thr Pro Gln Tyr Asn Leu Thr Ile 
        195                 200                 205             


Glu Val Ser Asp Lys Asp Phe Lys Thr Leu Cys Phe Val Gln Ile Asn 
    210                 215                 220                 


Val Ile Asp Ile Asn Asp Gln Ile Pro Ile Phe Glu Lys Ser Asp Tyr 
225                 230                 235                 240 


Gly Asn Leu Thr Leu Ala Glu Asp Thr Asn Ile Gly Ser Thr Ile Leu 
                245                 250                 255     


Thr Ile Gln Ala Thr Asp Ala Asp Glu Pro Phe Thr Gly Ser Ser Lys 
            260                 265                 270         


Ile Leu Tyr His Ile Ile Lys Gly Asp Ser Glu Gly Arg Leu Gly Val 
        275                 280                 285             


Asp Thr Asp Pro His Thr Asn Thr Gly Tyr Val Ile Ile Lys Lys Pro 
    290                 295                 300                 


Leu Asp Phe Glu Thr Ala Ala Val Ser Asn Ile Val Phe Lys Ala Glu 
305                 310                 315                 320 


Asn Pro Glu Pro Leu Val Phe Gly Val Lys Tyr Asn Ala Ser Ser Phe 
                325                 330                 335     


Ala Lys Phe Thr Leu Ile Val Thr Asp Val Asn Glu Ala Pro Gln Phe 
            340                 345                 350         


Ser Gln His Val Phe Gln Ala Lys Val Ser Glu Asp Val Ala Ile Gly 
        355                 360                 365             


Thr Lys Val Gly Asn Val Thr Ala Lys Asp Pro Glu Gly Leu Asp Ile 
    370                 375                 380                 


Ser Tyr Ser Leu Arg Gly Asp Thr Arg Gly Trp Leu Lys Ile Asp His 
385                 390                 395                 400 


Val Thr Gly Glu Ile Phe Ser Val Ala Pro Leu Asp Arg Glu Ala Gly 
                405                 410                 415     


Ser Pro Tyr Arg Val Gln Val Val Ala Thr Glu Val Gly Gly Ser Ser 
            420                 425                 430         


Leu Ser Ser Val Ser Glu Phe His Leu Ile Leu Met Asp Val Asn Asp 
        435                 440                 445             


Asn Pro Pro Arg Leu Ala Lys Asp Tyr Thr Gly Leu Phe Phe Cys His 
    450                 455                 460                 


Pro Leu Ser Ala Pro Gly Ser Leu Ile Phe Glu Ala Thr Asp Asp Asp 
465                 470                 475                 480 


Gln His Leu Phe Arg Gly Pro His Phe Thr Phe Ser Leu Gly Ser Gly 
                485                 490                 495     


Ser Leu Gln Asn Asp Trp Glu Val Ser Lys Ile Asn Gly Thr His Ala 
            500                 505                 510         


Arg Leu Ser Thr Arg His Thr Glu Phe Glu Glu Arg Glu Tyr Val Val 
        515                 520                 525             


Leu Ile Arg Ile Asn Asp Gly Gly Arg Pro Pro Leu Glu Gly Ile Val 
    530                 535                 540                 


Ser Leu Pro Gly Ile Ile Leu Ala Val Val Phe Ile Arg Ile Lys Lys 
545                 550                 555                 560 


Asp Lys Gly Lys Asp Asn Val Glu Ser Ala Gln Ala Ser Glu Val Lys 
                565                 570                 575     


Pro Leu Arg Ser 
            580 


<210>  2496
<211>  90
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2496

Xaa Ile Asp Ile Asn Asp Gln Ile Pro Ile Phe Glu Lys Ser Asp Tyr 
1               5                   10                  15      


Gly Asn Leu Thr Leu Ala Glu Asp Thr Asn Ile Gly Ser Thr Ile Leu 
            20                  25                  30          


Thr Ile Gln Ala Thr Asp Ala Asp Glu Pro Phe Thr Gly Ser Ser Lys 
        35                  40                  45              


Ile Leu Tyr His Ile Ile Lys Gly Asp Ser Glu Gly Arg Leu Gly Val 
    50                  55                  60                  


Asp Thr Asp Pro His Thr Asn Thr Gly Tyr Val Ile Ile Lys Lys Leu 
65                  70                  75                  80  


Phe Thr Glu Gly Arg His Lys Arg Leu Ala 
                85                  90  


<210>  2497
<211>  790
<212>  PRT
<213>  Homo Sapiens

<400>  2497

Met Lys Ile Thr Ser Thr Ser Cys Ile Cys Pro Val Leu Val Cys Leu 
1               5                   10                  15      


Cys Phe Val Gln Arg Cys Tyr Gly Thr Ala His His Ser Ser Ile Lys 
            20                  25                  30          


Val Met Arg Asn Gln Thr Lys His Ile Glu Gly Glu Thr Glu Val His 
        35                  40                  45              


His Arg Pro Lys Arg Gly Trp Val Trp Asn Gln Phe Phe Val Leu Glu 
    50                  55                  60                  


Glu His Met Gly Pro Asp Pro Gln Tyr Val Gly Lys Leu His Ser Asn 
65                  70                  75                  80  


Ser Asp Lys Gly Asp Gly Ser Val Lys Tyr Ile Leu Thr Gly Glu Gly 
                85                  90                  95      


Ala Gly Thr Ile Phe Ile Ile Asp Asp Thr Thr Gly Asp Ile His Ser 
            100                 105                 110         


Thr Lys Ser Leu Asp Arg Glu Gln Lys Thr His Tyr Val Leu His Ala 
        115                 120                 125             


Gln Ala Ile Asp Arg Arg Thr Asn Lys Pro Leu Glu Pro Glu Ser Glu 
    130                 135                 140                 


Phe Ile Ile Lys Val Gln Asp Ile Asn Asp Asn Ala Pro Lys Phe Thr 
145                 150                 155                 160 


Asp Gly Pro Tyr Ile Val Thr Val Pro Glu Met Ser Asp Met Gly Thr 
                165                 170                 175     


Ser Val Leu Gln Val Thr Ala Thr Asp Ala Asp Asp Pro Thr Tyr Gly 
            180                 185                 190         


Asn Ser Ala Arg Val Val Tyr Ser Ile Leu Gln Gly Gln Pro Tyr Phe 
        195                 200                 205             


Ser Val Asp Pro Lys Thr Gly Val Ile Arg Thr Ala Leu His Asn Met 
    210                 215                 220                 


Asp Arg Glu Ala Arg Glu His Tyr Ser Val Val Ile Gln Ala Lys Asp 
225                 230                 235                 240 


Met Ala Gly Gln Val Gly Gly Leu Ser Gly Ser Thr Thr Val Asn Ile 
                245                 250                 255     


Thr Leu Thr Asp Val Asn Asp Asn Pro Pro Arg Phe Pro Gln Lys His 
            260                 265                 270         


Tyr Gln Leu Tyr Val Pro Glu Ser Ala Gln Val Gly Ser Ala Val Gly 
        275                 280                 285             


Lys Ile Lys Ala Asn Asp Ala Asp Thr Gly Ser Asn Ala Asp Met Thr 
    290                 295                 300                 


Tyr Ser Ile Ile Asn Gly Asp Gly Met Gly Ile Phe Ser Ile Ser Thr 
305                 310                 315                 320 


Asp Lys Glu Thr Arg Glu Gly Ile Leu Ser Leu Lys Lys Pro Leu Asn 
                325                 330                 335     


Tyr Glu Lys Lys Lys Ser Tyr Thr Leu Asn Ile Glu Gly Ala Asn Thr 
            340                 345                 350         


His Leu Asp Phe Arg Phe Ser His Leu Gly Pro Phe Lys Asp Ala Thr 
        355                 360                 365             


Met Leu Lys Ile Ile Val Gly Asp Val Asp Glu Pro Pro Leu Phe Ser 
    370                 375                 380                 


Met Pro Ser Tyr Leu Met Glu Val Tyr Glu Asn Ala Lys Ile Gly Thr 
385                 390                 395                 400 


Val Val Gly Thr Val Leu Ala Gln Asp Pro Asp Ser Thr Asn Ser Leu 
                405                 410                 415     


Val Arg Tyr Phe Ile Asn Tyr Asn Val Glu Asp Asp Arg Phe Phe Asn 
            420                 425                 430         


Ile Asp Ala Asn Thr Gly Thr Ile Arg Thr Thr Lys Val Leu Asp Arg 
        435                 440                 445             


Glu Glu Thr Pro Trp Tyr Asn Ile Thr Val Thr Ala Ser Glu Ile Asp 
    450                 455                 460                 


Asn Pro Asp Leu Leu Ser His Val Thr Val Gly Ile Arg Val Leu Asp 
465                 470                 475                 480 


Val Asn Asp Asn Pro Pro Glu Leu Ala Arg Glu Tyr Asp Ile Ile Val 
                485                 490                 495     


Cys Glu Asn Ser Lys Pro Gly Gln Val Ile His Thr Ile Ser Ala Thr 
            500                 505                 510         


Asp Lys Asp Asp Phe Ala Asn Gly Pro Arg Phe Asn Phe Phe Leu Asp 
        515                 520                 525             


Glu Arg Leu Pro Val Asn Pro Asn Phe Thr Leu Lys Asp Asn Glu Asp 
    530                 535                 540                 


Asn Thr Ala Ser Ile Leu Thr Arg Arg Arg Arg Phe Ser Arg Thr Val 
545                 550                 555                 560 


Gln Asp Val Tyr Tyr Leu Pro Ile Met Ile Ser Asp Gly Gly Ile Pro 
                565                 570                 575     


Ser Leu Ser Ser Ser Ser Thr Leu Thr Ile Arg Val Cys Ala Cys Glu 
            580                 585                 590         


Arg Asp Gly Arg Val Arg Thr Cys His Ala Glu Ala Phe Leu Ser Ser 
        595                 600                 605             


Ala Gly Leu Ser Thr Gly Ala Leu Ile Ala Ile Leu Leu Cys Val Leu 
    610                 615                 620                 


Ile Leu Leu Ala Ile Val Val Leu Phe Ile Thr Leu Arg Arg Ser Lys 
625                 630                 635                 640 


Lys Glu Pro Leu Ile Ile Ser Glu Glu Asp Val Arg Glu Asn Val Val 
                645                 650                 655     


Thr Tyr Asp Asp Glu Gly Gly Gly Glu Glu Asp Thr Glu Ala Phe Asp 
            660                 665                 670         


Ile Thr Ala Leu Arg Asn Pro Ser Ala Ala Glu Glu Leu Lys Tyr Arg 
        675                 680                 685             


Arg Asp Ile Arg Pro Glu Val Lys Leu Thr Pro Arg His Gln Thr Ser 
    690                 695                 700                 


Ser Thr Leu Glu Ser Ile Asp Val Gln Glu Phe Ile Lys Gln Arg Leu 
705                 710                 715                 720 


Ala Glu Ala Asp Leu Asp Pro Ser Val Pro Pro Tyr Asp Ser Leu Gln 
                725                 730                 735     


Thr Tyr Ala Tyr Glu Gly Gln Arg Ser Glu Ala Gly Ser Ile Ser Ser 
            740                 745                 750         


Leu Asp Ser Ala Thr Thr Gln Ser Asp Gln Asp Tyr His Tyr Leu Gly 
        755                 760                 765             


Asp Trp Gly Pro Glu Phe Lys Lys Leu Ala Glu Leu Tyr Gly Glu Ile 
    770                 775                 780                 


Glu Ser Glu Arg Thr Thr 
785                 790 


<210>  2498
<211>  790
<212>  PRT
<213>  Homo Sapiens

<400>  2498

Met Lys Ile Thr Ser Thr Ser Cys Ile Cys Pro Val Leu Val Cys Leu 
1               5                   10                  15      


Cys Phe Val Gln Arg Cys Tyr Gly Thr Ala His His Ser Ser Ile Lys 
            20                  25                  30          


Val Met Arg Asn Gln Thr Lys His Ile Glu Gly Glu Thr Glu Val His 
        35                  40                  45              


His Arg Pro Lys Arg Gly Trp Val Trp Asn Gln Phe Phe Val Leu Glu 
    50                  55                  60                  


Glu His Met Gly Pro Asp Pro Gln Tyr Val Gly Lys Leu His Ser Asn 
65                  70                  75                  80  


Ser Asp Lys Gly Asp Gly Ser Val Lys Tyr Ile Leu Thr Gly Glu Gly 
                85                  90                  95      


Ala Gly Thr Ile Phe Ile Ile Asp Asp Thr Thr Gly Asp Ile His Ser 
            100                 105                 110         


Thr Lys Ser Leu Asp Arg Glu Gln Lys Thr His Tyr Val Leu His Ala 
        115                 120                 125             


Gln Ala Ile Asp Arg Arg Thr Asn Lys Pro Leu Glu Pro Glu Ser Glu 
    130                 135                 140                 


Phe Ile Ile Lys Val Gln Asp Ile Asn Asp Asn Ala Pro Lys Phe Thr 
145                 150                 155                 160 


Asp Gly Pro Tyr Ile Val Thr Val Pro Glu Met Ser Asp Met Gly Thr 
                165                 170                 175     


Ser Val Leu Gln Val Thr Ala Thr Asp Ala Asp Asp Pro Thr Tyr Gly 
            180                 185                 190         


Asn Ser Ala Arg Val Val Tyr Ser Ile Leu Gln Gly Gln Pro Tyr Phe 
        195                 200                 205             


Ser Val Asp Pro Lys Thr Gly Val Ile Arg Thr Ala Leu His Asn Met 
    210                 215                 220                 


Asp Arg Glu Ala Arg Glu His Tyr Ser Val Val Ile Gln Ala Lys Asp 
225                 230                 235                 240 


Met Ala Gly Gln Val Gly Gly Leu Ser Gly Ser Thr Thr Val Asn Ile 
                245                 250                 255     


Thr Leu Thr Asp Val Asn Asp Asn Pro Pro Arg Phe Pro Gln Lys His 
            260                 265                 270         


Tyr Gln Leu Tyr Val Pro Glu Ser Ala Gln Val Gly Ser Ala Val Gly 
        275                 280                 285             


Lys Ile Lys Ala Asn Asp Ala Asp Thr Gly Ser Asn Ala Asp Met Thr 
    290                 295                 300                 


Tyr Ser Ile Ile Asn Gly Asp Gly Met Gly Ile Phe Ser Ile Ser Thr 
305                 310                 315                 320 


Asp Lys Glu Thr Arg Glu Gly Ile Leu Ser Leu Lys Lys Pro Leu Asn 
                325                 330                 335     


Tyr Glu Lys Lys Lys Ser Tyr Thr Leu Asn Ile Glu Gly Ala Asn Thr 
            340                 345                 350         


His Leu Asp Phe Arg Phe Ser His Leu Gly Pro Phe Lys Asp Ala Thr 
        355                 360                 365             


Met Leu Lys Ile Ile Val Gly Asp Val Asp Glu Pro Pro Leu Phe Ser 
    370                 375                 380                 


Met Pro Ser Tyr Leu Met Glu Val Tyr Glu Asn Ala Lys Ile Gly Thr 
385                 390                 395                 400 


Val Val Gly Thr Val Leu Ala Gln Asp Pro Asp Ser Thr Asn Ser Leu 
                405                 410                 415     


Val Arg Tyr Phe Ile Asn Tyr Asn Val Glu Asp Asp Arg Phe Phe Asn 
            420                 425                 430         


Ile Asp Ala Asn Thr Gly Thr Ile Arg Thr Thr Lys Val Leu Asp Arg 
        435                 440                 445             


Glu Glu Thr Pro Trp Tyr Asn Ile Thr Val Thr Ala Ser Glu Ile Asp 
    450                 455                 460                 


Asn Pro Asp Leu Leu Ser His Val Thr Val Gly Ile Arg Val Leu Asp 
465                 470                 475                 480 


Val Asn Asp Asn Pro Pro Glu Leu Ala Arg Glu Tyr Asp Ile Ile Val 
                485                 490                 495     


Cys Glu Asn Ser Lys Pro Gly Gln Val Ile His Thr Ile Ser Ala Thr 
            500                 505                 510         


Asp Lys Asp Asp Phe Ala Asn Gly Pro Arg Phe Asn Phe Phe Leu Asp 
        515                 520                 525             


Glu Arg Leu Pro Val Asn Pro Asn Phe Thr Leu Lys Asp Asn Glu Asp 
    530                 535                 540                 


Asn Thr Ala Ser Ile Leu Thr Arg Arg Arg Arg Phe Ser Arg Thr Val 
545                 550                 555                 560 


Gln Asp Val Tyr Tyr Leu Pro Ile Met Ile Ser Asp Gly Gly Ile Pro 
                565                 570                 575     


Ser Leu Ser Ser Ser Ser Thr Leu Thr Ile Arg Val Cys Ala Cys Glu 
            580                 585                 590         


Arg Asp Gly Arg Val Arg Thr Cys His Ala Glu Ala Phe Leu Ser Ser 
        595                 600                 605             


Ala Gly Leu Ser Thr Gly Ala Leu Ile Ala Ile Leu Leu Cys Val Leu 
    610                 615                 620                 


Ile Leu Leu Ala Ile Val Val Leu Phe Ile Thr Leu Arg Arg Ser Lys 
625                 630                 635                 640 


Lys Glu Pro Leu Ile Ile Ser Glu Glu Asp Val Arg Glu Asn Val Val 
                645                 650                 655     


Thr Tyr Asp Asp Glu Gly Gly Gly Glu Glu Asp Thr Glu Ala Phe Asp 
            660                 665                 670         


Ile Thr Ala Leu Arg Asn Pro Ser Ala Ala Glu Glu Leu Lys Tyr Arg 
        675                 680                 685             


Arg Asp Ile Arg Pro Glu Val Lys Leu Thr Pro Arg His Gln Thr Ser 
    690                 695                 700                 


Ser Thr Leu Glu Ser Ile Asp Val Gln Glu Phe Ile Lys Gln Arg Leu 
705                 710                 715                 720 


Ala Glu Ala Asp Leu Asp Pro Ser Val Pro Pro Tyr Asp Ser Leu Gln 
                725                 730                 735     


Thr Tyr Ala Tyr Glu Gly Gln Arg Ser Glu Ala Gly Ser Ile Ser Ser 
            740                 745                 750         


Leu Asp Ser Ala Thr Thr Gln Ser Asp Gln Asp Tyr His Tyr Leu Gly 
        755                 760                 765             


Asp Trp Gly Pro Glu Phe Lys Lys Leu Ala Glu Leu Tyr Gly Glu Ile 
    770                 775                 780                 


Glu Ser Glu Arg Thr Thr 
785                 790 


<210>  2499
<211>  590
<212>  PRT
<213>  Homo Sapiens

<400>  2499

Met Lys Ile Thr Ser Thr Ser Cys Ile Cys Pro Val Leu Val Cys Leu 
1               5                   10                  15      


Cys Phe Val Gln Arg Cys Tyr Gly Thr Ala His His Ser Ser Ile Lys 
            20                  25                  30          


Val Met Arg Asn Gln Thr Lys His Ile Glu Gly Glu Thr Glu Val His 
        35                  40                  45              


His Arg Pro Lys Arg Gly Trp Val Trp Asn Gln Phe Phe Val Leu Glu 
    50                  55                  60                  


Glu His Met Gly Pro Asp Pro Gln Tyr Val Gly Lys Leu His Ser Asn 
65                  70                  75                  80  


Ser Asp Lys Gly Asp Gly Ser Val Lys Tyr Ile Leu Thr Gly Glu Gly 
                85                  90                  95      


Ala Gly Thr Ile Phe Ile Ile Asp Asp Thr Thr Gly Asp Ile His Ser 
            100                 105                 110         


Thr Lys Ser Leu Asp Arg Glu Gln Lys Thr His Tyr Val Leu His Ala 
        115                 120                 125             


Gln Ala Ile Asp Arg Arg Thr Asn Lys Pro Leu Glu Pro Glu Ser Glu 
    130                 135                 140                 


Phe Ile Ile Lys Val Gln Asp Ile Asn Asp Asn Ala Pro Lys Phe Thr 
145                 150                 155                 160 


Asp Gly Pro Tyr Ile Val Thr Val Pro Glu Met Ser Asp Met Gly Thr 
                165                 170                 175     


Ser Val Leu Gln Val Thr Ala Thr Asp Ala Asp Asp Pro Thr Tyr Gly 
            180                 185                 190         


Asn Ser Ala Arg Val Val Tyr Ser Ile Leu Gln Gly Gln Pro Tyr Phe 
        195                 200                 205             


Ser Val Asp Pro Lys Thr Gly Val Ile Arg Thr Ala Leu His Asn Met 
    210                 215                 220                 


Asp Arg Glu Ala Arg Glu His Tyr Ser Val Val Ile Gln Ala Lys Asp 
225                 230                 235                 240 


Met Ala Gly Gln Val Gly Gly Leu Ser Gly Ser Thr Thr Val Asn Ile 
                245                 250                 255     


Thr Leu Thr Asp Val Asn Asp Asn Pro Pro Arg Phe Pro Gln Lys His 
            260                 265                 270         


Tyr Gln Leu Tyr Val Pro Glu Ser Ala Gln Val Gly Ser Ala Val Gly 
        275                 280                 285             


Lys Ile Lys Ala Asn Asp Ala Asp Thr Gly Ser Asn Ala Asp Met Thr 
    290                 295                 300                 


Tyr Ser Ile Ile Asn Gly Asp Gly Met Gly Ile Phe Ser Ile Ser Thr 
305                 310                 315                 320 


Asp Lys Glu Thr Arg Glu Gly Ile Leu Ser Leu Lys Lys Pro Leu Asn 
                325                 330                 335     


Tyr Glu Lys Lys Lys Ser Tyr Thr Leu Asn Ile Glu Gly Ala Asn Thr 
            340                 345                 350         


His Leu Asp Phe Arg Phe Ser His Leu Gly Pro Phe Lys Asp Ala Thr 
        355                 360                 365             


Met Leu Lys Ile Ile Val Gly Asp Val Asp Glu Pro Pro Leu Phe Ser 
    370                 375                 380                 


Met Pro Ser Tyr Leu Met Glu Val Tyr Glu Asn Ala Lys Ile Gly Thr 
385                 390                 395                 400 


Val Val Gly Thr Val Leu Ala Gln Asp Pro Asp Ser Thr Asn Ser Leu 
                405                 410                 415     


Val Arg Tyr Phe Ile Asn Tyr Asn Val Glu Asp Asp Arg Phe Phe Asn 
            420                 425                 430         


Ile Asp Ala Asn Thr Gly Thr Ile Arg Thr Thr Lys Val Leu Asp Arg 
        435                 440                 445             


Glu Glu Thr Pro Trp Tyr Asn Ile Thr Val Thr Ala Ser Glu Ile Asp 
    450                 455                 460                 


Asn Pro Asp Leu Leu Ser His Val Thr Val Gly Ile Arg Val Leu Asp 
465                 470                 475                 480 


Val Asn Asp Asn Pro Pro Glu Leu Ala Arg Glu Tyr Asp Ile Ile Val 
                485                 490                 495     


Cys Glu Asn Ser Lys Pro Gly Gln Val Ile His Thr Ile Ser Ala Thr 
            500                 505                 510         


Asp Lys Asp Asp Phe Ala Asn Gly Pro Arg Phe Asn Phe Phe Leu Asp 
        515                 520                 525             


Glu Arg Leu Pro Val Asn Pro Asn Phe Thr Leu Lys Asp Asn Glu Gly 
    530                 535                 540                 


Glu His Ile Tyr Thr Tyr Leu Phe Ile Tyr Val Val Ser Ala Leu Thr 
545                 550                 555                 560 


Leu Tyr Val Ile Gly Phe Ile Leu Ile Tyr Thr Gln Thr Ser Cys Lys 
                565                 570                 575     


Ser Ala Phe Lys Val Ser Leu Met Leu Leu Cys Tyr Asp Leu 
            580                 585                 590 


<210>  2500
<211>  575
<212>  PRT
<213>  Homo Sapiens

<400>  2500

Met Lys Ile Thr Ser Thr Ser Cys Ile Cys Pro Val Leu Val Cys Leu 
1               5                   10                  15      


Cys Phe Val Gln Arg Cys Tyr Gly Thr Ala His His Ser Ser Ile Lys 
            20                  25                  30          


Val Met Arg Asn Gln Thr Lys His Ile Glu Gly Glu Thr Glu Val His 
        35                  40                  45              


His Arg Pro Lys Arg Gly Trp Val Trp Asn Gln Phe Phe Val Leu Glu 
    50                  55                  60                  


Glu His Met Gly Pro Asp Pro Gln Tyr Val Gly Lys Leu His Ser Asn 
65                  70                  75                  80  


Ser Asp Lys Gly Asp Gly Ser Val Lys Tyr Ile Leu Thr Gly Glu Gly 
                85                  90                  95      


Ala Gly Thr Ile Phe Ile Ile Asp Asp Thr Thr Gly Asp Ile His Ser 
            100                 105                 110         


Thr Lys Ser Leu Asp Arg Glu Gln Lys Thr His Tyr Val Leu His Ala 
        115                 120                 125             


Gln Ala Ile Asp Arg Arg Thr Asn Lys Pro Leu Glu Pro Glu Ser Glu 
    130                 135                 140                 


Phe Ile Ile Lys Val Gln Asp Ile Asn Asp Asn Ala Pro Lys Phe Thr 
145                 150                 155                 160 


Asp Gly Pro Tyr Ile Val Thr Val Pro Glu Met Ser Asp Met Gly Thr 
                165                 170                 175     


Ser Val Leu Gln Val Thr Ala Thr Asp Ala Asp Asp Pro Thr Tyr Gly 
            180                 185                 190         


Asn Ser Ala Arg Val Val Tyr Ser Ile Leu Gln Gly Gln Pro Tyr Phe 
        195                 200                 205             


Ser Val Asp Pro Lys Thr Gly Val Ile Arg Thr Ala Leu His Asn Met 
    210                 215                 220                 


Asp Arg Glu Ala Arg Glu His Tyr Ser Val Val Ile Gln Ala Lys Asp 
225                 230                 235                 240 


Met Ala Gly Gln Val Gly Gly Leu Ser Gly Ser Thr Thr Val Asn Ile 
                245                 250                 255     


Thr Leu Thr Asp Val Asn Asp Asn Pro Pro Arg Phe Pro Gln Lys His 
            260                 265                 270         


Tyr Gln Leu Tyr Val Pro Glu Ser Ala Gln Val Gly Ser Ala Val Gly 
        275                 280                 285             


Lys Ile Lys Ala Asn Asp Ala Asp Thr Gly Ser Asn Ala Asp Met Thr 
    290                 295                 300                 


Tyr Ser Ile Ile Asn Gly Asp Gly Met Gly Ile Phe Ser Ile Ser Thr 
305                 310                 315                 320 


Asp Lys Glu Thr Arg Glu Gly Ile Leu Ser Leu Lys Lys Pro Leu Asn 
                325                 330                 335     


Tyr Glu Lys Lys Lys Ser Tyr Thr Leu Asn Ile Glu Gly Ala Asn Thr 
            340                 345                 350         


His Leu Asp Phe Arg Phe Ser His Leu Gly Pro Phe Lys Asp Ala Thr 
        355                 360                 365             


Met Leu Lys Ile Ile Val Gly Asp Val Asp Glu Pro Pro Leu Phe Ser 
    370                 375                 380                 


Met Pro Ser Tyr Leu Met Glu Val Tyr Glu Asn Ala Lys Ile Gly Thr 
385                 390                 395                 400 


Val Val Gly Thr Val Leu Ala Gln Asp Pro Asp Ser Thr Asn Ser Leu 
                405                 410                 415     


Val Arg Tyr Phe Ile Asn Tyr Asn Val Glu Asp Asp Arg Phe Phe Asn 
            420                 425                 430         


Ile Asp Ala Asn Thr Gly Thr Ile Arg Thr Thr Lys Val Leu Asp Arg 
        435                 440                 445             


Glu Glu Thr Pro Trp Tyr Asn Ile Thr Val Thr Ala Ser Glu Ile Asp 
    450                 455                 460                 


Asn Pro Asp Leu Leu Ser His Val Thr Val Gly Ile Arg Val Leu Asp 
465                 470                 475                 480 


Val Asn Asp Asn Pro Pro Glu Leu Ala Arg Glu Tyr Asp Ile Ile Val 
                485                 490                 495     


Cys Glu Asn Ser Lys Pro Gly Gln Val Ile His Thr Ile Ser Ala Thr 
            500                 505                 510         


Asp Lys Asp Asp Phe Ala Asn Gly Pro Arg Phe Asn Phe Phe Leu Asp 
        515                 520                 525             


Glu Arg Leu Pro Val Asn Pro Asn Phe Thr Leu Lys Asp Asn Glu Ala 
    530                 535                 540                 


Ala Ala Ala Pro Ser Pro Ser Gly Phe Val His Ala Arg Glu Met Gly 
545                 550                 555                 560 


Val Cys Gly Pro Ala Met Gln Lys Pro Ser Cys Pro Arg Leu Val 
                565                 570                 575 


<210>  2501
<211>  790
<212>  PRT
<213>  Homo Sapiens

<400>  2501

Met Lys Ile Thr Ser Thr Ser Cys Ile Cys Pro Val Leu Val Cys Leu 
1               5                   10                  15      


Cys Phe Val Gln Arg Cys Tyr Gly Thr Ala His His Ser Ser Ile Lys 
            20                  25                  30          


Val Met Arg Asn Gln Thr Lys His Ile Glu Gly Glu Thr Glu Val His 
        35                  40                  45              


His Arg Pro Lys Arg Gly Trp Val Trp Asn Gln Phe Phe Val Leu Glu 
    50                  55                  60                  


Glu His Met Gly Pro Asp Pro Gln Tyr Val Gly Lys Leu His Ser Asn 
65                  70                  75                  80  


Ser Asp Lys Gly Asp Gly Ser Val Lys Tyr Ile Leu Thr Gly Glu Gly 
                85                  90                  95      


Ala Gly Thr Ile Phe Ile Ile Asp Asp Thr Thr Gly Asp Ile His Ser 
            100                 105                 110         


Thr Lys Ser Leu Asp Arg Glu Gln Lys Thr His Tyr Val Leu His Ala 
        115                 120                 125             


Gln Ala Ile Asp Arg Arg Thr Asn Lys Pro Leu Glu Pro Glu Ser Glu 
    130                 135                 140                 


Phe Ile Ile Lys Val Gln Asp Ile Asn Asp Asn Ala Pro Lys Phe Thr 
145                 150                 155                 160 


Asp Gly Pro Tyr Ile Val Thr Val Pro Glu Met Ser Asp Met Gly Thr 
                165                 170                 175     


Ser Val Leu Gln Val Thr Ala Thr Asp Ala Asp Asp Pro Thr Tyr Gly 
            180                 185                 190         


Asn Ser Ala Arg Val Val Tyr Ser Ile Leu Gln Gly Gln Pro Tyr Phe 
        195                 200                 205             


Ser Val Asp Pro Lys Thr Gly Val Ile Arg Thr Ala Leu His Asn Met 
    210                 215                 220                 


Asp Arg Glu Ala Arg Glu His Tyr Ser Val Val Ile Gln Ala Lys Asp 
225                 230                 235                 240 


Met Ala Gly Gln Val Gly Gly Leu Ser Gly Ser Thr Thr Val Asn Ile 
                245                 250                 255     


Thr Leu Thr Asp Val Asn Asp Asn Pro Pro Arg Phe Pro Gln Lys His 
            260                 265                 270         


Tyr Gln Leu Tyr Val Pro Glu Ser Ala Gln Val Gly Ser Ala Val Gly 
        275                 280                 285             


Lys Ile Lys Ala Asn Asp Ala Asp Thr Gly Ser Asn Ala Asp Met Thr 
    290                 295                 300                 


Tyr Ser Ile Ile Asn Gly Asp Gly Met Gly Ile Phe Ser Ile Ser Thr 
305                 310                 315                 320 


Asp Lys Glu Thr Arg Glu Gly Ile Leu Ser Leu Lys Lys Pro Leu Asn 
                325                 330                 335     


Tyr Glu Lys Lys Lys Ser Tyr Thr Leu Asn Ile Glu Gly Ala Asn Thr 
            340                 345                 350         


His Leu Asp Phe Arg Phe Ser His Leu Gly Pro Phe Lys Asp Ala Thr 
        355                 360                 365             


Met Leu Lys Ile Ile Val Gly Asp Val Asp Glu Pro Pro Leu Phe Ser 
    370                 375                 380                 


Met Pro Ser Tyr Leu Met Glu Val Tyr Glu Asn Ala Lys Ile Gly Thr 
385                 390                 395                 400 


Val Val Gly Thr Val Leu Ala Gln Asp Pro Asp Ser Thr Asn Ser Leu 
                405                 410                 415     


Val Arg Tyr Phe Ile Asn Tyr Asn Val Glu Asp Asp Arg Phe Phe Asn 
            420                 425                 430         


Ile Asp Ala Asn Thr Gly Thr Ile Arg Thr Thr Lys Val Leu Asp Arg 
        435                 440                 445             


Glu Glu Thr Pro Trp Tyr Asn Ile Thr Val Thr Ala Ser Glu Ile Asp 
    450                 455                 460                 


Asn Pro Asp Leu Leu Ser His Val Thr Val Gly Ile Arg Val Leu Asp 
465                 470                 475                 480 


Val Asn Asp Asn Pro Pro Glu Leu Ala Arg Glu Tyr Asp Ile Ile Val 
                485                 490                 495     


Cys Glu Asn Ser Lys Pro Gly Gln Val Ile His Thr Ile Ser Ala Thr 
            500                 505                 510         


Asp Lys Asp Asp Phe Ala Asn Gly Pro Arg Phe Asn Phe Phe Leu Asp 
        515                 520                 525             


Glu Arg Leu Pro Val Asn Pro Asn Phe Thr Leu Lys Asp Asn Glu Asp 
    530                 535                 540                 


Asn Thr Ala Ser Ile Leu Thr Arg Arg Arg Arg Phe Ser Arg Thr Val 
545                 550                 555                 560 


Gln Asp Val Tyr Tyr Leu Pro Ile Met Ile Ser Asp Gly Gly Ile Pro 
                565                 570                 575     


Ser Leu Ser Ser Ser Ser Thr Leu Thr Ile Arg Val Cys Ala Cys Glu 
            580                 585                 590         


Arg Asp Gly Arg Val Arg Thr Cys His Ala Glu Ala Phe Leu Ser Ser 
        595                 600                 605             


Ala Gly Leu Ser Thr Gly Ala Leu Ile Ala Ile Leu Leu Cys Val Leu 
    610                 615                 620                 


Ile Leu Leu Ala Ile Val Val Leu Phe Ile Thr Leu Arg Arg Ser Lys 
625                 630                 635                 640 


Lys Glu Pro Leu Ile Ile Ser Glu Glu Asp Val Arg Glu Asn Val Val 
                645                 650                 655     


Thr Tyr Asp Asp Glu Gly Gly Gly Glu Glu Asp Thr Glu Ala Phe Asp 
            660                 665                 670         


Ile Thr Ala Leu Arg Asn Pro Ser Ala Ala Glu Glu Leu Lys Tyr Arg 
        675                 680                 685             


Arg Asp Ile Arg Pro Glu Val Lys Leu Thr Pro Arg His Gln Thr Ser 
    690                 695                 700                 


Ser Thr Leu Glu Ser Ile Asp Val Gln Glu Phe Ile Lys Gln Arg Leu 
705                 710                 715                 720 


Ala Glu Ala Asp Leu Asp Pro Ser Val Pro Pro Tyr Asp Ser Leu Gln 
                725                 730                 735     


Thr Tyr Ala Tyr Glu Gly Gln Arg Ser Glu Ala Gly Ser Ile Ser Ser 
            740                 745                 750         


Leu Asp Ser Ala Thr Thr Gln Ser Asp Gln Asp Tyr His Tyr Leu Gly 
        755                 760                 765             


Asp Trp Gly Pro Glu Phe Lys Lys Leu Ala Glu Leu Tyr Gly Glu Ile 
    770                 775                 780                 


Glu Ser Glu Arg Thr Thr 
785                 790 


<210>  2502
<211>  574
<212>  PRT
<213>  Homo Sapiens

<400>  2502

Met Lys Ile Thr Ser Thr Ser Cys Ile Cys Pro Val Leu Val Cys Leu 
1               5                   10                  15      


Cys Phe Val Gln Arg Cys Tyr Gly Thr Ala His His Ser Ser Ile Lys 
            20                  25                  30          


Val Met Arg Asn Gln Thr Lys His Ile Glu Gly Glu Thr Glu Val His 
        35                  40                  45              


His Arg Pro Lys Arg Gly Trp Val Trp Asn Gln Phe Phe Val Leu Glu 
    50                  55                  60                  


Glu His Met Gly Pro Asp Pro Gln Tyr Val Gly Lys Leu His Ser Asn 
65                  70                  75                  80  


Ser Asp Lys Gly Asp Gly Ser Val Lys Tyr Ile Leu Thr Gly Glu Gly 
                85                  90                  95      


Ala Gly Thr Ile Phe Ile Ile Asp Asp Thr Thr Gly Asp Ile His Ser 
            100                 105                 110         


Thr Lys Ser Leu Asp Arg Glu Gln Lys Thr His Tyr Val Leu His Ala 
        115                 120                 125             


Gln Ala Ile Asp Arg Arg Thr Asn Lys Pro Leu Glu Pro Glu Ser Glu 
    130                 135                 140                 


Phe Ile Ile Lys Val Gln Asp Ile Asn Asp Asn Ala Pro Lys Phe Thr 
145                 150                 155                 160 


Asp Gly Pro Tyr Ile Val Thr Val Pro Glu Met Ser Asp Met Gly Thr 
                165                 170                 175     


Ser Val Leu Gln Val Thr Ala Thr Asp Ala Asp Asp Pro Thr Tyr Gly 
            180                 185                 190         


Asn Ser Ala Arg Val Val Tyr Ser Ile Leu Gln Gly Gln Pro Tyr Phe 
        195                 200                 205             


Ser Val Asp Pro Lys Thr Gly Val Ile Arg Thr Ala Leu His Asn Met 
    210                 215                 220                 


Asp Arg Glu Ala Arg Glu His Tyr Ser Val Val Ile Gln Ala Lys Asp 
225                 230                 235                 240 


Met Ala Gly Gln Val Gly Gly Leu Ser Gly Ser Thr Thr Val Asn Ile 
                245                 250                 255     


Thr Leu Thr Asp Val Asn Asp Asn Pro Pro Arg Phe Pro Gln Lys His 
            260                 265                 270         


Tyr Gln Leu Tyr Val Pro Glu Ser Ala Gln Val Gly Ser Ala Val Gly 
        275                 280                 285             


Lys Ile Lys Ala Asn Asp Ala Asp Thr Gly Ser Asn Ala Asp Met Thr 
    290                 295                 300                 


Tyr Ser Ile Ile Asn Gly Asp Gly Met Gly Ile Phe Ser Ile Ser Thr 
305                 310                 315                 320 


Asp Lys Glu Thr Arg Glu Gly Ile Leu Ser Leu Lys Lys Pro Leu Asn 
                325                 330                 335     


Tyr Glu Lys Lys Lys Ser Tyr Thr Leu Asn Ile Glu Gly Ala Asn Thr 
            340                 345                 350         


His Leu Asp Phe Arg Phe Ser His Leu Gly Pro Phe Lys Asp Ala Thr 
        355                 360                 365             


Met Leu Lys Ile Ile Val Gly Asp Val Asp Glu Pro Pro Leu Phe Ser 
    370                 375                 380                 


Met Pro Ser Tyr Leu Met Glu Val Tyr Glu Asn Ala Lys Ile Gly Thr 
385                 390                 395                 400 


Val Val Gly Thr Val Leu Ala Gln Asp Pro Asp Ser Thr Asn Ser Leu 
                405                 410                 415     


Val Arg Tyr Phe Ile Asn Tyr Asn Val Glu Asp Asp Arg Phe Phe Asn 
            420                 425                 430         


Ile Asp Ala Asn Thr Gly Thr Ile Arg Thr Thr Lys Val Leu Asp Arg 
        435                 440                 445             


Glu Glu Thr Pro Trp Tyr Asn Ile Thr Val Thr Ala Ser Glu Ile Asp 
    450                 455                 460                 


Asn Pro Asp Leu Leu Ser His Val Thr Val Gly Ile Arg Val Leu Asp 
465                 470                 475                 480 


Val Asn Asp Asn Pro Pro Glu Leu Ala Arg Glu Tyr Asp Ile Ile Val 
                485                 490                 495     


Cys Glu Asn Ser Lys Pro Gly Gln Val Ile His Thr Ile Ser Ala Thr 
            500                 505                 510         


Asp Lys Asp Asp Phe Ala Asn Gly Pro Arg Phe Asn Phe Phe Leu Asp 
        515                 520                 525             


Glu Arg Leu Pro Val Asn Pro Asn Phe Thr Leu Lys Asp Asn Glu Ala 
    530                 535                 540                 


Ala Ala Pro Ser Pro Ser Gly Phe Val His Ala Arg Glu Met Gly Val 
545                 550                 555                 560 


Cys Gly Pro Ala Met Gln Lys Pro Ser Cys Pro Arg Leu Val 
                565                 570                 


<210>  2503
<211>  441
<212>  PRT
<213>  Homo Sapiens

<400>  2503

Trp Val Trp Asn Gln Phe Phe Val Leu Glu Glu His Met Gly Pro Asp 
1               5                   10                  15      


Pro Gln Tyr Val Gly Lys Leu His Ser Asn Ser Asp Lys Gly Asp Gly 
            20                  25                  30          


Ser Val Lys Tyr Ile Leu Thr Gly Glu Gly Ala Gly Thr Ile Phe Ile 
        35                  40                  45              


Ile Asp Asp Thr Thr Gly Asp Ile His Ser Thr Lys Ser Leu Asp Arg 
    50                  55                  60                  


Glu Gln Lys Thr His Tyr Val Leu His Ala Gln Ala Ile Asp Arg Arg 
65                  70                  75                  80  


Thr Asn Lys Pro Leu Glu Pro Glu Ser Glu Phe Ile Ile Lys Val Gln 
                85                  90                  95      


Asp Ile Asn Asp Asn Ala Pro Lys Phe Thr Asp Gly Pro Tyr Ile Val 
            100                 105                 110         


Thr Val Pro Glu Met Ser Asp Met Gly Thr Ser Val Leu Gln Val Thr 
        115                 120                 125             


Ala Thr Asp Ala Asp Asp Pro Thr Tyr Gly Asn Ser Ala Arg Val Val 
    130                 135                 140                 


Tyr Ser Ile Leu Gln Gly Gln Pro Tyr Phe Ser Val Asp Pro Lys Thr 
145                 150                 155                 160 


Gly Val Ile Arg Thr Ala Leu His Asn Met Asp Arg Glu Ala Arg Glu 
                165                 170                 175     


His Tyr Ser Val Val Ile Gln Ala Lys Asp Met Ala Gly Gln Val Gly 
            180                 185                 190         


Gly Leu Ser Gly Ser Thr Thr Val Asn Ile Thr Leu Thr Asp Val Asn 
        195                 200                 205             


Asp Asn Pro Pro Arg Phe Pro Gln Lys His Tyr Gln Leu Tyr Val Pro 
    210                 215                 220                 


Glu Ser Ala Gln Val Gly Ser Ala Val Gly Lys Ile Lys Ala Asn Asp 
225                 230                 235                 240 


Ala Asp Thr Gly Ser Asn Ala Asp Met Thr Tyr Ser Ile Ile Asn Gly 
                245                 250                 255     


Asp Gly Met Gly Ile Phe Ser Ile Ser Thr Asp Lys Glu Thr Arg Glu 
            260                 265                 270         


Gly Ile Leu Ser Leu Lys Lys Pro Leu Asn Tyr Glu Lys Lys Lys Ser 
        275                 280                 285             


Tyr Thr Leu Asn Ile Glu Gly Ala Asn Thr His Leu Asp Phe Arg Phe 
    290                 295                 300                 


Ser His Leu Gly Pro Phe Lys Asp Ala Thr Met Leu Lys Ile Ile Val 
305                 310                 315                 320 


Gly Asp Val Asp Glu Pro Pro Leu Phe Ser Met Pro Ser Tyr Leu Met 
                325                 330                 335     


Glu Val Tyr Glu Asn Ala Lys Ile Gly Thr Val Val Gly Thr Val Leu 
            340                 345                 350         


Ala Gln Asp Pro Asp Ser Thr Asn Ser Leu Val Arg Tyr Phe Ile Asn 
        355                 360                 365             


Tyr Asn Val Glu Asp Asp Arg Phe Phe Asn Ile Asp Ala Asn Thr Gly 
    370                 375                 380                 


Thr Ile Arg Thr Thr Lys Val Leu Asp Arg Glu Glu Thr Pro Trp Tyr 
385                 390                 395                 400 


Asn Ile Thr Val Thr Ala Ser Glu Ile Ala Ala Ala Ala Pro Ser Pro 
                405                 410                 415     


Ser Gly Phe Val His Ala Arg Glu Met Gly Val Cys Gly Pro Ala Met 
            420                 425                 430         


Gln Lys Pro Ser Cys Pro Arg Leu Val 
        435                 440     


<210>  2504
<211>  434
<212>  PRT
<213>  Homo Sapiens

<400>  2504

Gly Ile Pro Leu Leu Trp Pro Cys Leu Gly Ala Thr Glu Asn Ser Gln 
1               5                   10                  15      


Thr Lys Lys Val Lys Gln Pro Val Arg Ser His Leu Arg Val Lys Arg 
            20                  25                  30          


Gly Trp Val Trp Asn Gln Phe Phe Val Pro Glu Glu Met Asn Thr Thr 
        35                  40                  45              


Ser His His Ile Gly Gln Leu Arg Ser Asp Leu Asp Asn Gly Asn Asn 
    50                  55                  60                  


Ser Phe Gln Tyr Lys Leu Leu Gly Ala Gly Ala Gly Ser Thr Phe Ile 
65                  70                  75                  80  


Ile Asp Glu Arg Thr Gly Asp Ile Tyr Ala Ile Gln Lys Leu Asp Arg 
                85                  90                  95      


Glu Glu Arg Ser Leu Tyr Ile Leu Arg Ala Gln Val Ile Asp Ile Ala 
            100                 105                 110         


Thr Gly Arg Ala Val Glu Pro Glu Ser Glu Phe Val Ile Lys Val Ser 
        115                 120                 125             


Asp Ile Asn Asp Asn Glu Pro Lys Phe Leu Asp Glu Pro Tyr Glu Ala 
    130                 135                 140                 


Ile Val Pro Glu Met Ser Pro Glu Gly Thr Leu Val Ile Gln Val Thr 
145                 150                 155                 160 


Ala Ser Asp Ala Asp Asp Pro Ser Ser Gly Asn Asn Ala Arg Leu Leu 
                165                 170                 175     


Tyr Ser Leu Leu Gln Gly Gln Pro Tyr Phe Ser Val Glu Pro Thr Thr 
            180                 185                 190         


Gly Val Ile Arg Ile Ser Ser Lys Met Asp Arg Glu Leu Gln Asp Glu 
        195                 200                 205             


Tyr Trp Val Ile Ile Gln Ala Lys Asp Met Ile Gly Gln Pro Gly Ala 
    210                 215                 220                 


Leu Ser Gly Thr Thr Ser Val Leu Ile Lys Leu Ser Asp Val Asn Asp 
225                 230                 235                 240 


Asn Lys Pro Ile Phe Lys Glu Ser Leu Tyr Arg Leu Thr Val Ser Glu 
                245                 250                 255     


Ser Ala Pro Thr Gly Thr Ser Ile Gly Thr Ile Met Ala Tyr Asp Asn 
            260                 265                 270         


Asp Ile Gly Glu Asn Ala Glu Met Asp Tyr Ser Ile Glu Glu Asp Asp 
        275                 280                 285             


Ser Gln Thr Phe Asp Ile Ile Thr Asn His Glu Thr Gln Glu Gly Ile 
    290                 295                 300                 


Val Ile Leu Lys Lys Lys Val Asp Phe Glu His Gln Asn His Tyr Gly 
305                 310                 315                 320 


Ile Arg Ala Lys Val Lys Asn His His Val Pro Glu Gln Leu Met Lys 
                325                 330                 335     


Tyr His Thr Glu Ala Ser Thr Thr Phe Ile Lys Ile Gln Val Glu Asp 
            340                 345                 350         


Val Asp Glu Pro Pro Leu Phe Leu Leu Pro Tyr Tyr Val Phe Glu Val 
        355                 360                 365             


Phe Glu Glu Thr Pro Gln Gly Ser Phe Val Gly Val Val Ser Ala Thr 
    370                 375                 380                 


Asp Pro Asp Asn Arg Lys Ser Pro Ile Arg Tyr Ser Ile Thr Arg Ser 
385                 390                 395                 400 


Lys Val Phe Asn Ile Asn Asp Asn Gly Thr Ile Thr Thr Ser Asn Ser 
                405                 410                 415     


Leu Asp Arg Glu Ile Ser Ala Trp Tyr Asn Leu Ser Ile Thr Ala Thr 
            420                 425                 430         


Glu Lys 
        


<210>  2505
<211>  65
<212>  PRT
<213>  Homo Sapiens

<400>  2505

Met Asn Cys Tyr Leu Leu Leu Arg Phe Met Leu Gly Ile Pro Leu Leu 
1               5                   10                  15      


Trp Pro Cys Leu Gly Ala Thr Glu Asn Ser Gln Thr Lys Lys Val Lys 
            20                  25                  30          


Gln Pro Val Arg Ser His Leu Arg Val Lys Arg Gly Trp Val Trp Asn 
        35                  40                  45              


Gln Phe Phe Val Pro Glu Glu Met Asn Thr Thr Ser His His Ile Gly 
    50                  55                  60                  


Gln 
65  


<210>  2506
<211>  772
<212>  PRT
<213>  Homo Sapiens

<400>  2506

Met Asn Cys Tyr Leu Leu Leu Arg Phe Met Leu Gly Ile Pro Leu Leu 
1               5                   10                  15      


Trp Pro Cys Leu Gly Ala Thr Glu Asn Ser Gln Thr Lys Lys Val Lys 
            20                  25                  30          


Gln Pro Val Arg Ser His Leu Arg Val Lys Arg Gly Trp Val Trp Asn 
        35                  40                  45              


Gln Phe Phe Val Pro Glu Glu Met Asn Thr Thr Ser His His Ile Gly 
    50                  55                  60                  


Gln Leu Arg Ser Asp Leu Asp Asn Gly Asn Asn Ser Phe Gln Tyr Lys 
65                  70                  75                  80  


Leu Leu Gly Ala Gly Ala Gly Ser Thr Phe Ile Ile Asp Glu Arg Thr 
                85                  90                  95      


Gly Asp Ile Tyr Ala Ile Gln Lys Leu Asp Arg Glu Glu Arg Ser Leu 
            100                 105                 110         


Tyr Ile Leu Arg Ala Gln Val Ile Asp Ile Ala Thr Gly Arg Ala Val 
        115                 120                 125             


Glu Pro Glu Ser Glu Phe Val Ile Lys Val Ser Asp Ile Asn Asp Asn 
    130                 135                 140                 


Glu Pro Lys Phe Leu Asp Glu Pro Tyr Glu Ala Ile Val Pro Glu Met 
145                 150                 155                 160 


Ser Pro Glu Gly Thr Leu Val Ile Gln Val Thr Ala Ser Asp Ala Asp 
                165                 170                 175     


Asp Pro Ser Ser Gly Asn Asn Ala Arg Leu Leu Tyr Ser Leu Leu Gln 
            180                 185                 190         


Gly Gln Pro Tyr Phe Ser Val Glu Pro Thr Thr Gly Val Ile Arg Ile 
        195                 200                 205             


Ser Ser Lys Met Asp Arg Glu Leu Gln Asp Glu Tyr Trp Val Ile Ile 
    210                 215                 220                 


Gln Ala Lys Asp Met Ile Gly Gln Pro Gly Ala Leu Ser Gly Thr Thr 
225                 230                 235                 240 


Ser Val Leu Ile Lys Leu Ser Asp Val Asn Asp Asn Lys Pro Ile Phe 
                245                 250                 255     


Lys Glu Ser Leu Tyr Arg Leu Thr Val Ser Glu Ser Ala Pro Thr Gly 
            260                 265                 270         


Thr Ser Ile Gly Thr Ile Met Ala Tyr Asp Asn Asp Ile Gly Glu Asn 
        275                 280                 285             


Ala Glu Met Asp Tyr Ser Ile Glu Glu Asp Asp Ser Gln Thr Phe Asp 
    290                 295                 300                 


Ile Ile Thr Asn His Glu Thr Gln Glu Gly Ile Val Ile Leu Lys Lys 
305                 310                 315                 320 


Lys Val Asp Phe Glu His Gln Asn His Tyr Gly Ile Arg Ala Lys Val 
                325                 330                 335     


Lys Asn His His Val Pro Glu Gln Leu Met Lys Tyr His Thr Glu Ala 
            340                 345                 350         


Ser Thr Thr Phe Ile Lys Ile Gln Val Glu Asp Val Asp Glu Pro Pro 
        355                 360                 365             


Leu Phe Leu Leu Pro Tyr Tyr Val Phe Glu Val Phe Glu Glu Thr Pro 
    370                 375                 380                 


Gln Gly Ser Phe Val Gly Val Val Ser Ala Thr Asp Pro Asp Asn Arg 
385                 390                 395                 400 


Lys Ser Pro Ile Arg Tyr Ser Ile Thr Arg Ser Lys Val Phe Asn Ile 
                405                 410                 415     


Asn Asp Asn Gly Thr Ile Thr Thr Ser Asn Ser Leu Asp Arg Glu Ile 
            420                 425                 430         


Ser Ala Trp Tyr Asn Leu Ser Ile Thr Ala Thr Glu Lys Tyr Asn Ile 
        435                 440                 445             


Glu Gln Ile Ser Ser Ile Pro Leu Tyr Val Gln Val Leu Asn Ile Asn 
    450                 455                 460                 


Asp His Ala Pro Glu Phe Ser Gln Tyr Tyr Glu Thr Tyr Val Cys Glu 
465                 470                 475                 480 


Asn Ala Gly Ser Gly Gln Val Ile Gln Thr Ile Ser Ala Val Asp Arg 
                485                 490                 495     


Asp Glu Ser Ile Glu Glu His His Phe Tyr Phe Asn Leu Ser Val Glu 
            500                 505                 510         


Asp Thr Asn Asn Ser Ser Phe Thr Ile Ile Asp Asn Gln Asp Asn Thr 
        515                 520                 525             


Ala Val Ile Leu Thr Asn Arg Thr Gly Phe Asn Leu Gln Glu Glu Pro 
    530                 535                 540                 


Val Phe Tyr Ile Ser Ile Leu Ile Ala Asp Asn Gly Ile Pro Ser Leu 
545                 550                 555                 560 


Thr Ser Thr Asn Thr Leu Thr Ile His Val Cys Asp Cys Gly Asp Ser 
                565                 570                 575     


Gly Ser Thr Gln Thr Cys Gln Tyr Gln Glu Leu Val Leu Ser Met Gly 
            580                 585                 590         


Phe Lys Thr Glu Val Ile Ile Ala Ile Leu Ile Cys Ile Met Ile Ile 
        595                 600                 605             


Phe Gly Phe Ile Phe Leu Thr Leu Gly Leu Lys Gln Arg Arg Lys Gln 
    610                 615                 620                 


Ile Leu Phe Pro Glu Lys Ser Glu Asp Phe Arg Glu Asn Ile Phe Gln 
625                 630                 635                 640 


Tyr Asp Asp Glu Gly Gly Gly Glu Glu Asp Thr Glu Ala Phe Asp Ile 
                645                 650                 655     


Ala Glu Leu Arg Ser Ser Thr Ile Met Arg Glu Arg Lys Thr Arg Lys 
            660                 665                 670         


Thr Thr Ser Ala Glu Ile Arg Ser Leu Tyr Arg Gln Ser Leu Gln Val 
        675                 680                 685             


Gly Pro Asp Ser Ala Ile Phe Arg Lys Phe Ile Leu Glu Lys Leu Glu 
    690                 695                 700                 


Glu Ala Asn Thr Asp Pro Cys Ala Pro Pro Phe Asp Ser Leu Gln Thr 
705                 710                 715                 720 


Tyr Ala Phe Glu Gly Thr Gly Ser Leu Ala Gly Ser Leu Ser Ser Leu 
                725                 730                 735     


Glu Ser Ala Val Ser Asp Gln Asp Glu Ser Tyr Asp Tyr Leu Asn Glu 
            740                 745                 750         


Leu Gly Pro Arg Phe Lys Arg Leu Ala Cys Met Phe Gly Ser Ala Val 
        755                 760                 765             


Gln Ser Asn Asn 
    770         


<210>  2507
<211>  490
<212>  PRT
<213>  Homo Sapiens

<400>  2507

Met Asn Cys Tyr Leu Leu Leu Arg Phe Met Leu Gly Ile Pro Leu Leu 
1               5                   10                  15      


Trp Pro Cys Leu Gly Ala Thr Glu Asn Ser Gln Thr Lys Lys Val Lys 
            20                  25                  30          


Gln Pro Val Arg Ser His Leu Arg Val Lys Arg Gly Trp Val Trp Asn 
        35                  40                  45              


Gln Phe Phe Val Pro Glu Glu Met Asn Thr Thr Ser His His Ile Gly 
    50                  55                  60                  


Gln Leu Arg Ser Asp Leu Asp Asn Gly Asn Asn Ser Phe Gln Tyr Lys 
65                  70                  75                  80  


Leu Leu Gly Ala Gly Ala Gly Ser Thr Phe Ile Ile Asp Glu Arg Thr 
                85                  90                  95      


Gly Asp Ile Tyr Ala Ile Gln Lys Leu Asp Arg Glu Glu Arg Ser Leu 
            100                 105                 110         


Tyr Ile Leu Arg Ala Gln Val Ile Asp Ile Ala Thr Gly Arg Ala Val 
        115                 120                 125             


Glu Pro Glu Ser Glu Phe Val Ile Lys Val Ser Asp Ile Asn Asp Asn 
    130                 135                 140                 


Glu Pro Lys Phe Leu Asp Glu Pro Tyr Glu Ala Ile Val Pro Glu Met 
145                 150                 155                 160 


Ser Pro Glu Gly Thr Leu Val Ile Gln Val Thr Ala Ser Asp Ala Asp 
                165                 170                 175     


Asp Pro Ser Ser Gly Asn Asn Ala Arg Leu Leu Tyr Ser Leu Leu Gln 
            180                 185                 190         


Gly Gln Pro Tyr Phe Ser Val Glu Pro Thr Thr Gly Val Ile Arg Ile 
        195                 200                 205             


Ser Ser Lys Met Asp Arg Glu Leu Gln Asp Glu Tyr Trp Val Ile Ile 
    210                 215                 220                 


Gln Ala Lys Asp Met Ile Gly Gln Pro Gly Ala Leu Ser Gly Thr Thr 
225                 230                 235                 240 


Ser Val Leu Ile Lys Leu Ser Asp Val Asn Asp Asn Lys Pro Ile Phe 
                245                 250                 255     


Lys Glu Ser Leu Tyr Arg Leu Thr Val Ser Glu Ser Ala Pro Thr Gly 
            260                 265                 270         


Thr Ser Ile Gly Thr Ile Met Ala Tyr Asp Asn Asp Ile Gly Glu Asn 
        275                 280                 285             


Ala Glu Met Asp Tyr Ser Ile Glu Glu Asp Asp Ser Gln Thr Phe Asp 
    290                 295                 300                 


Ile Ile Thr Asn His Glu Thr Gln Glu Gly Ile Val Ile Leu Lys Lys 
305                 310                 315                 320 


Lys Val Asp Phe Glu His Gln Asn His Tyr Gly Ile Arg Ala Lys Val 
                325                 330                 335     


Lys Asn His His Val Pro Glu Gln Leu Met Lys Tyr His Thr Glu Ala 
            340                 345                 350         


Ser Thr Thr Phe Ile Lys Ile Gln Val Glu Asp Val Asp Glu Pro Pro 
        355                 360                 365             


Leu Phe Leu Leu Pro Tyr Tyr Val Phe Glu Val Phe Glu Glu Thr Pro 
    370                 375                 380                 


Gln Gly Ser Phe Val Gly Val Val Ser Ala Thr Asp Pro Asp Asn Arg 
385                 390                 395                 400 


Lys Ser Pro Ile Arg Tyr Ser Ile Thr Arg Ser Lys Val Phe Asn Ile 
                405                 410                 415     


Asn Asp Asn Gly Thr Ile Thr Thr Ser Asn Ser Leu Asp Arg Glu Ile 
            420                 425                 430         


Ser Ala Trp Tyr Asn Leu Ser Ile Thr Ala Thr Glu Lys Tyr Asn Ile 
        435                 440                 445             


Glu Gln Ile Ser Ser Ile Pro Leu Tyr Val Gln Val Leu Asn Ile Asn 
    450                 455                 460                 


Asp His Ala Pro Glu Phe Ser Gln Tyr Tyr Glu Thr Tyr Val Cys Glu 
465                 470                 475                 480 


Asn Ala Gly Ser Gly Gln Gly Leu Phe Phe 
                485                 490 


<210>  2508
<211>  541
<212>  PRT
<213>  Homo Sapiens

<400>  2508

Met Asn Cys Tyr Leu Leu Leu Arg Phe Met Leu Gly Ile Pro Leu Leu 
1               5                   10                  15      


Trp Pro Cys Leu Gly Ala Thr Glu Asn Ser Gln Thr Lys Lys Val Lys 
            20                  25                  30          


Gln Pro Val Arg Ser His Leu Arg Val Lys Arg Gly Trp Val Trp Asn 
        35                  40                  45              


Gln Phe Phe Val Pro Glu Glu Met Asn Thr Thr Ser His His Ile Gly 
    50                  55                  60                  


Gln Leu Arg Ser Asp Leu Asp Asn Gly Asn Asn Ser Phe Gln Tyr Lys 
65                  70                  75                  80  


Leu Leu Gly Ala Gly Ala Gly Ser Thr Phe Ile Ile Asp Glu Arg Thr 
                85                  90                  95      


Gly Asp Ile Tyr Ala Ile Gln Lys Leu Asp Arg Glu Glu Arg Ser Leu 
            100                 105                 110         


Tyr Ile Leu Arg Ala Gln Val Ile Asp Ile Ala Thr Gly Arg Ala Val 
        115                 120                 125             


Glu Pro Glu Ser Glu Phe Val Ile Lys Val Ser Asp Ile Asn Asp Asn 
    130                 135                 140                 


Glu Pro Lys Phe Leu Asp Glu Pro Tyr Glu Ala Ile Val Pro Glu Met 
145                 150                 155                 160 


Ser Pro Glu Gly Thr Leu Val Ile Gln Val Thr Ala Ser Asp Ala Asp 
                165                 170                 175     


Asp Pro Ser Ser Gly Asn Asn Ala Arg Leu Leu Tyr Ser Leu Leu Gln 
            180                 185                 190         


Gly Gln Pro Tyr Phe Ser Val Glu Pro Thr Thr Gly Val Ile Arg Ile 
        195                 200                 205             


Ser Ser Lys Met Asp Arg Glu Leu Gln Asp Glu Tyr Trp Val Ile Ile 
    210                 215                 220                 


Gln Ala Lys Asp Met Ile Gly Gln Pro Gly Ala Leu Ser Gly Thr Thr 
225                 230                 235                 240 


Ser Val Leu Ile Lys Leu Ser Asp Val Asn Asp Asn Lys Pro Ile Phe 
                245                 250                 255     


Lys Glu Ser Leu Tyr Arg Leu Thr Val Ser Glu Ser Ala Pro Thr Gly 
            260                 265                 270         


Thr Ser Ile Gly Thr Ile Met Ala Tyr Asp Asn Asp Ile Gly Glu Asn 
        275                 280                 285             


Ala Glu Met Asp Tyr Ser Ile Glu Glu Asp Asp Ser Gln Thr Phe Asp 
    290                 295                 300                 


Ile Ile Thr Asn His Glu Thr Gln Glu Gly Ile Val Ile Leu Lys Lys 
305                 310                 315                 320 


Lys Val Asp Phe Glu His Gln Asn His Tyr Gly Ile Arg Ala Lys Val 
                325                 330                 335     


Lys Asn His His Val Pro Glu Gln Leu Met Lys Tyr His Thr Glu Ala 
            340                 345                 350         


Ser Thr Thr Phe Ile Lys Ile Gln Val Glu Asp Val Asp Glu Pro Pro 
        355                 360                 365             


Leu Phe Leu Leu Pro Tyr Tyr Val Phe Glu Val Phe Glu Glu Thr Pro 
    370                 375                 380                 


Gln Gly Ser Phe Val Gly Val Val Ser Ala Thr Asp Pro Asp Asn Arg 
385                 390                 395                 400 


Lys Ser Pro Ile Arg Tyr Ser Ile Thr Arg Ser Lys Val Phe Asn Ile 
                405                 410                 415     


Asn Asp Asn Gly Thr Ile Thr Thr Ser Asn Ser Leu Asp Arg Glu Ile 
            420                 425                 430         


Ser Ala Trp Tyr Asn Leu Ser Ile Thr Ala Thr Glu Lys Tyr Asn Ile 
        435                 440                 445             


Glu Gln Ile Ser Ser Ile Pro Leu Tyr Val Gln Val Leu Asn Ile Asn 
    450                 455                 460                 


Asp His Ala Pro Glu Phe Ser Gln Tyr Tyr Glu Thr Tyr Val Cys Glu 
465                 470                 475                 480 


Asn Ala Gly Ser Gly Gln Val Ile Gln Thr Ile Ser Ala Val Asp Arg 
                485                 490                 495     


Asp Glu Ser Ile Glu Glu His His Phe Tyr Phe Asn Leu Ser Val Glu 
            500                 505                 510         


Asp Thr Asn Asn Ser Ser Phe Thr Ile Ile Asp Asn Gln Glu Leu Val 
        515                 520                 525             


Leu Thr Phe Lys Lys Asn Leu Ser Ser Thr Ser Pro Ser 
    530                 535                 540     


<210>  2509
<211>  445
<212>  PRT
<213>  Homo Sapiens

<400>  2509

Met Asp Asn Asp Pro Leu Val Phe Gly Val Ser Gly Glu Glu Ala Ser 
1               5                   10                  15      


Arg Phe Phe Ala Val Glu Pro Asp Thr Gly Val Val Trp Leu Arg Gln 
            20                  25                  30          


Pro Leu Asp Arg Glu Thr Lys Ser Glu Phe Thr Val Glu Phe Ser Val 
        35                  40                  45              


Ser Asp His Gln Gly Val Ile Thr Arg Lys Val Asn Ile Gln Val Gly 
    50                  55                  60                  


Asp Val Asn Asp Asn Ala Pro Thr Phe His Asn Gln Pro Tyr Ser Val 
65                  70                  75                  80  


Arg Ile Pro Glu Asn Thr Pro Val Gly Thr Pro Ile Phe Ile Val Asn 
                85                  90                  95      


Ala Thr Asp Pro Asp Leu Gly Ala Gly Gly Ser Val Leu Tyr Ser Phe 
            100                 105                 110         


Gln Pro Pro Ser Gln Phe Phe Ala Ile Asp Ser Ala Arg Gly Ile Val 
        115                 120                 125             


Thr Val Ile Arg Glu Leu Asp Tyr Glu Thr Thr Gln Ala Tyr Gln Leu 
    130                 135                 140                 


Thr Val Asn Ala Leu Ala Ile Ile Ile Thr Asn Leu Pro Tyr Ser Thr 
145                 150                 155                 160 


Asn Ile Tyr Glu His Ser Pro Pro Gly Thr Thr Val Arg Ile Ile Thr 
                165                 170                 175     


Ala Ile Asp Gln Asp Lys Gly Arg Pro Arg Gly Ile Gly Tyr Thr Ile 
            180                 185                 190         


Val Ser Gly Asn Thr Asn Ser Ile Phe Ala Leu Asp Tyr Ile Ser Gly 
        195                 200                 205             


Val Leu Thr Leu Asn Gly Leu Leu Asp Arg Glu Asn Pro Leu Tyr Ser 
    210                 215                 220                 


His Gly Phe Ile Leu Thr Val Lys Gly Thr Glu Leu Asn Asp Asp Arg 
225                 230                 235                 240 


Thr Pro Ser Asp Ala Thr Val Thr Thr Thr Phe Asn Ile Leu Val Ile 
                245                 250                 255     


Asp Ile Asn Asp Asn Ala Pro Glu Phe Asn Ser Ser Glu Tyr Ser Val 
            260                 265                 270         


Ala Ile Thr Glu Leu Ala Gln Val Gly Phe Ala Leu Pro Leu Phe Ile 
        275                 280                 285             


Gln Val Val Asp Lys Asp Glu Gly Leu Asn Ser Met Phe Glu Val Tyr 
    290                 295                 300                 


Leu Val Gly Asn Asn Ser His His Phe Ile Ile Ser Pro Thr Ser Val 
305                 310                 315                 320 


Gln Gly Lys Ala Asp Ile Arg Ile Arg Val Ala Ile Pro Leu Asp Tyr 
                325                 330                 335     


Glu Thr Val Asp Arg Tyr Asp Phe Asp Leu Phe Ala Asn Glu Ser Val 
            340                 345                 350         


Pro Asp His Val Gly Tyr Ala Lys Val Lys Ile Thr Leu Ile Asn Glu 
        355                 360                 365             


Asn Asp Asn Arg Pro Ile Phe Ser Gln Pro Leu Tyr Asn Ile Ser Leu 
    370                 375                 380                 


Tyr Glu Asn Val Thr Val Gly Thr Ser Val Leu Thr Val Leu Val Ser 
385                 390                 395                 400 


Pro Arg Phe Thr Ala Gly Pro Leu Ser Ser Pro Gly Pro Thr Val Val 
                405                 410                 415     


Arg His Pro Glu Gly Phe Cys Pro Arg Asp Leu Ser Asn Gln Gly Arg 
            420                 425                 430         


Arg His Pro Gln Ile Pro Glu Leu Cys Leu Leu Val Tyr 
        435                 440                 445 


<210>  2510
<211>  3354
<212>  PRT
<213>  Homo Sapiens

<400>  2510

Met Gly Arg His Val Ala Thr Ser Cys His Val Ala Trp Leu Leu Val 
1               5                   10                  15      


Leu Ile Ser Gly Cys Trp Gly Gln Val Asn Arg Leu Pro Phe Phe Thr 
            20                  25                  30          


Asn His Phe Phe Asp Thr Tyr Leu Leu Ile Ser Glu Asp Thr Pro Val 
        35                  40                  45              


Gly Ser Ser Val Thr Gln Leu Leu Ala Gln Asp Met Asp Asn Asp Pro 
    50                  55                  60                  


Leu Val Phe Gly Val Ser Gly Glu Glu Ala Ser Arg Phe Phe Ala Val 
65                  70                  75                  80  


Glu Pro Asp Thr Gly Val Val Trp Leu Arg Gln Pro Leu Asp Arg Glu 
                85                  90                  95      


Thr Lys Ser Glu Phe Thr Val Glu Phe Ser Val Ser Asp His Gln Gly 
            100                 105                 110         


Val Ile Thr Arg Lys Val Asn Ile Gln Val Gly Asp Val Asn Asp Asn 
        115                 120                 125             


Ala Pro Thr Phe His Asn Gln Pro Tyr Ser Val Arg Ile Pro Glu Asn 
    130                 135                 140                 


Thr Pro Val Gly Thr Pro Ile Phe Ile Val Asn Ala Thr Asp Pro Asp 
145                 150                 155                 160 


Leu Gly Ala Gly Gly Ser Val Leu Tyr Ser Phe Gln Pro Pro Ser Gln 
                165                 170                 175     


Phe Phe Ala Ile Asp Ser Ala Arg Gly Ile Val Thr Val Ile Arg Glu 
            180                 185                 190         


Leu Asp Tyr Glu Thr Thr Gln Ala Tyr Gln Leu Thr Val Asn Ala Thr 
        195                 200                 205             


Asp Gln Asp Lys Thr Arg Pro Leu Ser Thr Leu Ala Asn Leu Ala Ile 
    210                 215                 220                 


Ile Ile Thr Asp Val Gln Asp Met Asp Pro Ile Phe Ile Asn Leu Pro 
225                 230                 235                 240 


Tyr Ser Thr Asn Ile Tyr Glu His Ser Pro Pro Gly Thr Thr Val Arg 
                245                 250                 255     


Ile Ile Thr Ala Ile Asp Gln Asp Lys Gly Arg Pro Arg Gly Ile Gly 
            260                 265                 270         


Tyr Thr Ile Val Ser Gly Asn Thr Asn Ser Ile Phe Ala Leu Asp Tyr 
        275                 280                 285             


Ile Ser Gly Val Leu Thr Leu Asn Gly Leu Leu Asp Arg Glu Asn Pro 
    290                 295                 300                 


Leu Tyr Ser His Gly Phe Ile Leu Thr Val Lys Gly Thr Glu Leu Asn 
305                 310                 315                 320 


Asp Asp Arg Thr Pro Ser Asp Ala Thr Val Thr Thr Thr Phe Asn Ile 
                325                 330                 335     


Leu Val Ile Asp Ile Asn Asp Asn Ala Pro Glu Phe Asn Ser Ser Glu 
            340                 345                 350         


Tyr Ser Val Ala Ile Thr Glu Leu Ala Gln Val Gly Phe Ala Leu Pro 
        355                 360                 365             


Leu Phe Ile Gln Val Val Asp Lys Asp Glu Asn Leu Gly Leu Asn Ser 
    370                 375                 380                 


Met Phe Glu Val Tyr Leu Val Gly Asn Asn Ser His His Phe Ile Ile 
385                 390                 395                 400 


Ser Pro Thr Ser Val Gln Gly Lys Ala Asp Ile Arg Ile Arg Val Ala 
                405                 410                 415     


Ile Pro Leu Asp Tyr Glu Thr Val Asp Arg Tyr Asp Phe Asp Leu Phe 
            420                 425                 430         


Ala Asn Glu Ser Val Pro Asp His Val Gly Tyr Ala Lys Val Lys Ile 
        435                 440                 445             


Thr Leu Ile Asn Glu Asn Asp Asn Arg Pro Ile Phe Ser Gln Pro Leu 
    450                 455                 460                 


Tyr Asn Ile Ser Leu Tyr Glu Asn Val Thr Val Gly Thr Ser Val Leu 
465                 470                 475                 480 


Thr Val Leu Ala Thr Asp Asn Asp Ala Gly Thr Phe Gly Glu Val Ser 
                485                 490                 495     


Tyr Phe Phe Ser Asp Asp Pro Asp Arg Phe Ser Leu Asp Lys Asp Thr 
            500                 505                 510         


Gly Leu Ile Met Leu Ile Ala Arg Leu Asp Tyr Glu Leu Ile Gln Arg 
        515                 520                 525             


Phe Thr Leu Thr Ile Ile Ala Arg Asp Gly Gly Gly Glu Glu Thr Thr 
    530                 535                 540                 


Gly Arg Val Arg Ile Asn Val Leu Asp Val Asn Asp Asn Val Pro Thr 
545                 550                 555                 560 


Phe Gln Lys Asp Ala Tyr Val Gly Ala Leu Arg Glu Asn Glu Pro Ser 
                565                 570                 575     


Val Thr Gln Leu Val Arg Leu Arg Ala Thr Asp Glu Asp Ser Pro Pro 
            580                 585                 590         


Asn Asn Gln Ile Thr Tyr Ser Ile Val Ser Ala Ser Ala Phe Gly Ser 
        595                 600                 605             


Tyr Phe Asp Ile Ser Leu Tyr Glu Gly Tyr Gly Val Ile Ser Val Ser 
    610                 615                 620                 


Arg Pro Leu Asp Tyr Glu Gln Ile Ser Asn Gly Leu Ile Tyr Leu Thr 
625                 630                 635                 640 


Val Met Ala Met Asp Ala Gly Asn Pro Pro Leu Asn Ser Thr Val Pro 
                645                 650                 655     


Val Thr Ile Glu Val Phe Asp Glu Asn Asp Asn Pro Pro Thr Phe Ser 
            660                 665                 670         


Lys Pro Ala Tyr Phe Val Ser Val Val Glu Asn Ile Met Ala Gly Ala 
        675                 680                 685             


Thr Val Leu Phe Leu Asn Ala Thr Asp Leu Asp Arg Ser Arg Glu Tyr 
    690                 695                 700                 


Gly Gln Glu Ser Ile Ile Tyr Ser Leu Glu Gly Ser Thr Gln Phe Arg 
705                 710                 715                 720 


Ile Asn Ala Arg Ser Gly Glu Ile Thr Thr Thr Ser Leu Leu Asp Arg 
                725                 730                 735     


Glu Thr Lys Ser Glu Tyr Ile Leu Ile Val Arg Ala Val Asp Gly Gly 
            740                 745                 750         


Val Gly His Asn Gln Lys Thr Gly Ile Ala Thr Val Asn Ile Thr Leu 
        755                 760                 765             


Leu Asp Ile Asn Asp Asn His Pro Thr Trp Lys Asp Ala Pro Tyr Tyr 
    770                 775                 780                 


Ile Asn Leu Val Glu Met Thr Pro Pro Asp Ser Asp Val Thr Thr Val 
785                 790                 795                 800 


Val Ala Val Asp Pro Asp Leu Gly Glu Asn Gly Thr Leu Val Tyr Ser 
                805                 810                 815     


Ile Gln Pro Pro Asn Lys Phe Tyr Ser Leu Asn Ser Thr Thr Gly Lys 
            820                 825                 830         


Ile Arg Thr Thr His Ala Met Leu Asp Arg Glu Asn Pro Asp Pro His 
        835                 840                 845             


Glu Ala Glu Leu Met Arg Lys Ile Val Val Ser Val Thr Asp Cys Gly 
    850                 855                 860                 


Arg Pro Pro Leu Lys Ala Thr Ser Ser Ala Thr Val Phe Val Asn Leu 
865                 870                 875                 880 


Leu Asp Leu Asn Asp Asn Asp Pro Thr Phe Gln Asn Leu Pro Phe Val 
                885                 890                 895     


Ala Glu Val Leu Glu Gly Ile Pro Ala Gly Val Ser Ile Tyr Gln Val 
            900                 905                 910         


Val Ala Ile Asp Leu Asp Glu Gly Leu Asn Gly Leu Val Ser Tyr Arg 
        915                 920                 925             


Met Pro Val Gly Met Pro Arg Met Asp Phe Leu Ile Asn Ser Ser Ser 
    930                 935                 940                 


Gly Val Val Val Thr Thr Thr Glu Leu Asp Arg Glu Arg Ile Ala Glu 
945                 950                 955                 960 


Tyr Gln Leu Arg Val Val Ala Ser Asp Ala Gly Thr Pro Thr Lys Ser 
                965                 970                 975     


Ser Thr Ser Thr Leu Thr Ile His Val Leu Asp Val Asn Asp Glu Thr 
            980                 985                 990         


Pro Thr Phe Phe Pro Ala Val Tyr  Asn Val Ser Val Ser  Glu Asp Val 
        995                 1000                 1005             


Pro Arg  Glu Phe Arg Val Val  Trp Leu Asn Cys Thr  Asp Asn Asp 
    1010                 1015                 1020             


Val Gly  Leu Asn Ala Glu Leu  Ser Tyr Phe Ile Thr  Gly Gly Asn 
    1025                 1030                 1035             


Val Asp  Gly Lys Phe Ser Val  Gly Tyr Arg Asp Ala  Val Val Arg 
    1040                 1045                 1050             


Thr Val  Val Gly Leu Asp Arg  Glu Thr Thr Ala Ala  Tyr Met Leu 
    1055                 1060                 1065             


Ile Leu  Glu Ala Ile Asp Asn  Gly Pro Val Gly Lys  Arg His Thr 
    1070                 1075                 1080             


Gly Thr  Ala Thr Val Phe Val  Thr Val Leu Asp Val  Asn Asp Asn 
    1085                 1090                 1095             


Arg Pro  Ile Phe Leu Gln Ser  Ser Tyr Glu Ala Ser  Val Pro Glu 
    1100                 1105                 1110             


Asp Ile  Pro Glu Gly His Ser  Ile Leu Gln Leu Lys  Ala Thr Asp 
    1115                 1120                 1125             


Ala Asp  Glu Gly Glu Phe Gly  Arg Val Trp Tyr Arg  Ile Leu His 
    1130                 1135                 1140             


Gly Asn  His Gly Asn Asn Phe  Arg Ile His Val Ser  Asn Gly Leu 
    1145                 1150                 1155             


Leu Met  Arg Gly Pro Arg Pro  Leu Asp Arg Glu Arg  Asn Ser Ser 
    1160                 1165                 1170             


His Val  Leu Ile Val Glu Ala  Tyr Asn His Asp Leu  Gly Pro Met 
    1175                 1180                 1185             


Arg Ser  Ser Val Arg Val Ile  Val Tyr Val Glu Asp  Ile Asn Asp 
    1190                 1195                 1200             


Glu Ala  Pro Val Phe Thr Gln  Gln Gln Tyr Ser Arg  Leu Gly Leu 
    1205                 1210                 1215             


Arg Glu  Thr Ala Gly Ile Gly  Thr Ser Val Ile Val  Val Gln Ala 
    1220                 1225                 1230             


Thr Asp  Arg Asp Ser Gly Asp  Gly Gly Leu Val Asn  Tyr Arg Ile 
    1235                 1240                 1245             


Leu Ser  Gly Ala Glu Gly Lys  Phe Glu Ile Asp Glu  Ser Thr Gly 
    1250                 1255                 1260             


Leu Ile  Ile Thr Val Asn Tyr  Leu Asp Tyr Glu Thr  Lys Thr Ser 
    1265                 1270                 1275             


Tyr Met  Met Asn Val Ser Ala  Thr Asp Gln Ala Pro  Pro Phe Asn 
    1280                 1285                 1290             


Gln Gly  Phe Cys Ser Val Tyr  Ile Thr Leu Leu Asn  Glu Leu Asp 
    1295                 1300                 1305             


Glu Ala  Val Gln Phe Ser Asn  Ala Ser Tyr Glu Ala  Ala Ile Leu 
    1310                 1315                 1320             


Glu Asn  Leu Ala Leu Gly Thr  Glu Ile Val Arg Val  Gln Ala Tyr 
    1325                 1330                 1335             


Ser Ile  Asp Asn Leu Asn Gln  Ile Thr Tyr Arg Phe  Asn Ala Tyr 
    1340                 1345                 1350             


Thr Ser  Thr Gln Ala Lys Ala  Leu Phe Lys Ile Asp  Ala Ile Thr 
    1355                 1360                 1365             


Gly Val  Ile Thr Val Gln Gly  Leu Val Asp Arg Glu  Lys Gly Asp 
    1370                 1375                 1380             


Phe Tyr  Thr Leu Thr Val Val  Ala Asp Asp Gly Gly  Pro Lys Val 
    1385                 1390                 1395             


Asp Ser  Thr Val Lys Val Tyr  Ile Thr Val Leu Asp  Glu Asn Asp 
    1400                 1405                 1410             


Asn Ser  Pro Arg Phe Asp Phe  Thr Ser Asp Ser Ala  Val Ser Ile 
    1415                 1420                 1425             


Pro Glu  Asp Cys Pro Val Gly  Gln Arg Val Ala Thr  Val Lys Ala 
    1430                 1435                 1440             


Trp Asp  Pro Asp Ala Gly Ser  Asn Gly Gln Val Val  Phe Ser Leu 
    1445                 1450                 1455             


Ala Ser  Gly Asn Ile Ala Gly  Ala Phe Glu Ile Val  Thr Thr Asn 
    1460                 1465                 1470             


Asp Ser  Ile Gly Glu Val Phe  Val Ala Arg Pro Leu  Asp Arg Glu 
    1475                 1480                 1485             


Glu Leu  Asp His Tyr Ile Leu  Gln Val Val Ala Ser  Asp Arg Gly 
    1490                 1495                 1500             


Thr Pro  Pro Arg Lys Lys Asp  His Ile Leu Gln Val  Thr Ile Leu 
    1505                 1510                 1515             


Asp Ile  Asn Asp Asn Pro Pro  Val Ile Glu Ser Pro  Phe Gly Tyr 
    1520                 1525                 1530             


Asn Val  Ser Val Asn Glu Asn  Val Gly Gly Gly Thr  Ala Val Val 
    1535                 1540                 1545             


Gln Val  Arg Ala Thr Asp Arg  Asp Ile Gly Ile Asn  Ser Val Leu 
    1550                 1555                 1560             


Ser Tyr  Tyr Ile Thr Glu Gly  Asn Lys Asp Met Ala  Phe Arg Met 
    1565                 1570                 1575             


Asp Arg  Ile Ser Gly Glu Ile  Ala Thr Arg Pro Ala  Pro Pro Asp 
    1580                 1585                 1590             


Arg Glu  Arg Gln Ser Phe Tyr  His Leu Val Ala Thr  Val Glu Asp 
    1595                 1600                 1605             


Glu Gly  Thr Pro Thr Leu Ser  Ala Thr Thr His Val  Tyr Val Thr 
    1610                 1615                 1620             


Ile Val  Asp Glu Asn Asp Asn  Ala Pro Met Phe Gln  Gln Pro His 
    1625                 1630                 1635             


Tyr Glu  Val Leu Leu Asp Glu  Gly Pro Asp Thr Leu  Asn Thr Ser 
    1640                 1645                 1650             


Leu Ile  Thr Ile Gln Ala Leu  Asp Leu Asp Glu Gly  Pro Asn Gly 
    1655                 1660                 1665             


Thr Val  Thr Tyr Ala Ile Val  Ala Gly Asn Ile Val  Asn Thr Phe 
    1670                 1675                 1680             


Arg Ile  Asp Arg His Met Gly  Val Ile Thr Ala Ala  Lys Glu Leu 
    1685                 1690                 1695             


Asp Tyr  Glu Ile Ser His Gly  Arg Tyr Thr Leu Ile  Val Thr Ala 
    1700                 1705                 1710             


Thr Asp  Gln Cys Pro Ile Leu  Ser His Arg Leu Thr  Ser Thr Thr 
    1715                 1720                 1725             


Thr Val  Leu Val Asn Val Asn  Asp Ile Asn Asp Asn  Val Pro Thr 
    1730                 1735                 1740             


Phe Pro  Arg Asp Tyr Glu Gly  Pro Phe Glu Val Thr  Glu Gly Gln 
    1745                 1750                 1755             


Pro Gly  Pro Arg Val Trp Thr  Phe Leu Ala His Asp  Arg Asp Ser 
    1760                 1765                 1770             


Gly Pro  Asn Gly Gln Val Glu  Tyr Ser Ile Met Asp  Gly Asp Pro 
    1775                 1780                 1785             


Leu Gly  Glu Phe Val Ile Ser  Pro Val Glu Gly Val  Leu Arg Val 
    1790                 1795                 1800             


Arg Lys  Asp Val Glu Leu Asp  Arg Glu Thr Ile Ala  Phe Tyr Asn 
    1805                 1810                 1815             


Leu Thr  Ile Cys Ala Arg Asp  Arg Gly Met Pro Pro  Leu Ser Ser 
    1820                 1825                 1830             


Thr Met  Leu Val Gly Ile Arg  Val Leu Asp Ile Asn  Asp Asn Asp 
    1835                 1840                 1845             


Pro Val  Leu Leu Asn Leu Pro  Met Asn Ile Thr Ile  Ser Glu Asn 
    1850                 1855                 1860             


Ser Pro  Val Ser Ser Phe Val  Ala His Val Leu Ala  Ser Asp Ala 
    1865                 1870                 1875             


Asp Ser  Gly Cys Asn Ala Arg  Leu Thr Phe Asn Ile  Thr Ala Gly 
    1880                 1885                 1890             


Asn Arg  Glu Arg Ala Phe Phe  Ile Asn Ala Thr Thr  Gly Ile Val 
    1895                 1900                 1905             


Thr Val  Asn Arg Pro Leu Asp  Arg Glu Arg Ile Pro  Glu Tyr Lys 
    1910                 1915                 1920             


Leu Thr  Ile Ser Val Lys Asp  Asn Pro Glu Asn Pro  Arg Ile Ala 
    1925                 1930                 1935             


Arg Arg  Asp Tyr Asp Leu Leu  Leu Ile Phe Leu Ser  Asp Glu Asn 
    1940                 1945                 1950             


Asp Asn  His Pro Leu Phe Thr  Lys Ser Thr Tyr Gln  Ala Glu Val 
    1955                 1960                 1965             


Met Glu  Asn Ser Pro Ala Gly  Thr Pro Leu Thr Val  Leu Asn Gly 
    1970                 1975                 1980             


Pro Ile  Leu Ala Leu Asp Ala  Asp Gln Asp Ile Tyr  Ala Val Val 
    1985                 1990                 1995             


Thr Tyr  Gln Leu Leu Gly Ala  Gln Ser Gly Leu Phe  Asp Ile Asn 
    2000                 2005                 2010             


Ser Ser  Thr Gly Val Val Thr  Val Arg Ser Gly Val  Ile Ile Asp 
    2015                 2020                 2025             


Arg Glu  Ala Phe Ser Pro Pro  Ile Leu Glu Leu Leu  Leu Leu Ala 
    2030                 2035                 2040             


Glu Asp  Ile Gly Leu Leu Asn  Ser Thr Ala His Leu  Leu Ile Thr 
    2045                 2050                 2055             


Ile Leu  Asp Asp Asn Asp Asn  Arg Pro Thr Phe Ser  Pro Ala Thr 
    2060                 2065                 2070             


Leu Thr  Val His Leu Leu Glu  Asn Cys Pro Pro Gly  Phe Ser Val 
    2075                 2080                 2085             


Leu Gln  Val Thr Ala Thr Asp  Glu Asp Ser Gly Leu  Asn Gly Glu 
    2090                 2095                 2100             


Leu Val  Tyr Arg Ile Glu Ala  Gly Ala Gln Asp Arg  Phe Leu Ile 
    2105                 2110                 2115             


His Leu  Val Thr Gly Val Ile  Arg Val Gly Asn Ala  Thr Ile Asp 
    2120                 2125                 2130             


Arg Glu  Glu Gln Glu Ser Tyr  Arg Leu Thr Val Val  Ala Thr Asp 
    2135                 2140                 2145             


Arg Gly  Thr Val Pro Leu Ser  Gly Thr Ala Ile Val  Thr Ile Leu 
    2150                 2155                 2160             


Ile Asp  Asp Ile Asn Asp Ser  Arg Pro Glu Phe Leu  Asn Pro Ile 
    2165                 2170                 2175             


Gln Thr  Val Ser Val Leu Glu  Ser Ala Glu Pro Gly  Thr Val Ile 
    2180                 2185                 2190             


Ala Asn  Ile Thr Ala Ile Asp  His Asp Leu Asn Pro  Lys Leu Glu 
    2195                 2200                 2205             


Tyr His  Ile Val Gly Ile Val  Ala Lys Asp Asp Thr  Asp Arg Leu 
    2210                 2215                 2220             


Val Pro  Asn Gln Glu Asp Ala  Phe Ala Val Asn Ile  Asn Thr Gly 
    2225                 2230                 2235             


Ser Val  Met Val Lys Ser Pro  Met Asn Arg Glu Leu  Val Ala Thr 
    2240                 2245                 2250             


Tyr Glu  Val Thr Leu Ser Val  Ile Asp Asn Ala Ser  Asp Leu Pro 
    2255                 2260                 2265             


Glu Arg  Ser Val Ser Val Pro  Asn Ala Lys Leu Thr  Val Asn Val 
    2270                 2275                 2280             


Leu Asp  Val Asn Asp Asn Thr  Pro Gln Phe Lys Pro  Phe Gly Ile 
    2285                 2290                 2295             


Thr Tyr  Tyr Met Glu Arg Ile  Leu Glu Gly Ala Thr  Pro Gly Thr 
    2300                 2305                 2310             


Thr Leu  Ile Ala Val Ala Ala  Val Asp Pro Asp Lys  Gly Leu Asn 
    2315                 2320                 2325             


Gly Leu  Val Thr Tyr Thr Leu  Leu Asp Leu Val Pro  Pro Gly Tyr 
    2330                 2335                 2340             


Val Gln  Leu Glu Asp Ser Ser  Ala Gly Lys Val Ile  Ala Asn Arg 
    2345                 2350                 2355             


Thr Val  Asp Tyr Glu Glu Val  His Trp Leu Asn Phe  Thr Val Arg 
    2360                 2365                 2370             


Ala Ser  Asp Asn Gly Ser Pro  Pro Arg Ala Ala Glu  Ile Pro Val 
    2375                 2380                 2385             


Tyr Leu  Glu Ile Val Asp Ile  Asn Asp Asn Asn Pro  Ile Phe Asp 
    2390                 2395                 2400             


Gln Pro  Ser Tyr Gln Glu Ala  Val Phe Glu Asp Val  Pro Val Gly 
    2405                 2410                 2415             


Thr Ile  Ile Leu Thr Val Thr  Ala Thr Asp Ala Asp  Ser Gly Asn 
    2420                 2425                 2430             


Phe Ala  Leu Ile Glu Tyr Ser  Leu Gly Asp Gly Glu  Ser Lys Phe 
    2435                 2440                 2445             


Ala Ile  Asn Pro Thr Thr Gly  Asp Ile Tyr Val Leu  Ser Ser Leu 
    2450                 2455                 2460             


Asp Arg  Glu Lys Lys Asp His  Tyr Ile Leu Thr Ala  Leu Ala Lys 
    2465                 2470                 2475             


Asp Asn  Pro Gly Asp Val Ala  Ser Asn Arg Arg Glu  Asn Ser Val 
    2480                 2485                 2490             


Gln Val  Val Ile Gln Val Leu  Asp Val Asn Asp Cys  Arg Pro Gln 
    2495                 2500                 2505             


Phe Ser  Lys Pro Gln Phe Ser  Thr Ser Val Tyr Glu  Asn Glu Pro 
    2510                 2515                 2520             


Ala Gly  Thr Ser Val Ile Thr  Met Met Ala Thr Asp  Gln Asp Glu 
    2525                 2530                 2535             


Gly Pro  Asn Gly Glu Leu Thr  Tyr Ser Leu Glu Gly  Pro Gly Val 
    2540                 2545                 2550             


Glu Ala  Phe His Val Asp Met  Asp Ser Gly Leu Val  Thr Thr Gln 
    2555                 2560                 2565             


Arg Pro  Leu Gln Ser Tyr Glu  Lys Phe Ser Leu Thr  Val Val Ala 
    2570                 2575                 2580             


Thr Asp  Gly Gly Glu Pro Pro  Leu Trp Gly Thr Thr  Met Leu Leu 
    2585                 2590                 2595             


Val Glu  Val Ile Asp Val Asn  Asp Asn Arg Pro Val  Phe Val Arg 
    2600                 2605                 2610             


Pro Pro  Asn Gly Thr Ile Leu  His Ile Arg Glu Glu  Ile Pro Leu 
    2615                 2620                 2625             


Arg Ser  Asn Val Tyr Glu Val  Tyr Ala Thr Asp Lys  Asp Glu Gly 
    2630                 2635                 2640             


Leu Asn  Gly Ala Val Arg Tyr  Ser Phe Leu Lys Thr  Ala Gly Asn 
    2645                 2650                 2655             


Arg Asp  Trp Glu Phe Phe Ile  Ile Asp Pro Ile Ser  Gly Leu Ile 
    2660                 2665                 2670             


Gln Thr  Ala Gln Arg Leu Asp  Arg Glu Ser Gln Ala  Val Tyr Ser 
    2675                 2680                 2685             


Leu Ile  Leu Val Ala Ser Asp  Leu Gly Gln Pro Val  Pro Tyr Glu 
    2690                 2695                 2700             


Thr Met  Gln Pro Leu Gln Val  Ala Leu Glu Asp Ile  Asp Asp Asn 
    2705                 2710                 2715             


Glu Pro  Leu Phe Val Arg Pro  Pro Lys Gly Ser Pro  Gln Tyr Gln 
    2720                 2725                 2730             


Leu Leu  Thr Val Pro Glu His  Ser Pro Arg Gly Thr  Leu Val Gly 
    2735                 2740                 2745             


Asn Val  Thr Gly Ala Val Asp  Ala Asp Glu Gly Pro  Asn Ala Ile 
    2750                 2755                 2760             


Val Tyr  Tyr Phe Ile Ala Ala  Gly Asn Glu Glu Lys  Asn Phe His 
    2765                 2770                 2775             


Leu Gln  Pro Asp Gly Cys Leu  Leu Val Leu Arg Asp  Leu Asp Arg 
    2780                 2785                 2790             


Glu Arg  Glu Ala Ile Phe Ser  Phe Ile Val Lys Ala  Ser Ser Asn 
    2795                 2800                 2805             


Arg Ser  Trp Thr Pro Pro Arg  Gly Pro Ser Pro Thr  Leu Asp Leu 
    2810                 2815                 2820             


Val Ala  Asp Leu Thr Leu Gln  Glu Val Arg Val Val  Leu Glu Asp 
    2825                 2830                 2835             


Ile Asn  Asp Gln Pro Pro Arg  Phe Thr Lys Ala Glu  Tyr Thr Ala 
    2840                 2845                 2850             


Gly Val  Ala Thr Asp Ala Lys  Val Gly Ser Glu Leu  Ile Gln Val 
    2855                 2860                 2865             


Leu Ala  Leu Asp Ala Asp Ile  Gly Asn Asn Ser Leu  Val Phe Tyr 
    2870                 2875                 2880             


Ser Ile  Leu Ala Ile His Tyr  Phe Arg Ala Leu Ala  Asn Asp Ser 
    2885                 2890                 2895             


Glu Asp  Val Gly Gln Val Phe  Thr Met Gly Ser Met  Asp Gly Ile 
    2900                 2905                 2910             


Leu Arg  Thr Phe Asp Leu Phe  Met Ala Tyr Ser Pro  Gly Tyr Phe 
    2915                 2920                 2925             


Val Val  Asp Ile Val Ala Arg  Asp Leu Ala Gly His  Asn Asp Thr 
    2930                 2935                 2940             


Ala Ile  Ile Gly Ile Tyr Ile  Leu Arg Asp Asp Gln  Arg Val Lys 
    2945                 2950                 2955             


Ile Val  Ile Asn Glu Ile Pro  Asp Arg Val Arg Gly  Phe Glu Glu 
    2960                 2965                 2970             


Glu Phe  Ile His Leu Leu Ser  Asn Ile Thr Gly Ala  Ile Val Asn 
    2975                 2980                 2985             


Thr Asp  Asn Val Gln Phe His  Val Asp Lys Lys Gly  Arg Val Asn 
    2990                 2995                 3000             


Phe Ala  Gln Thr Glu Leu Leu  Ile His Val Val Asn  Arg Asp Thr 
    3005                 3010                 3015             


Asn Arg  Ile Leu Asp Val Asp  Arg Val Ile Gln Met  Ile Asp Glu 
    3020                 3025                 3030             


Asn Lys  Glu Gln Leu Arg Asn  Leu Phe Arg Asn Tyr  Asn Val Leu 
    3035                 3040                 3045             


Asp Val  Gln Pro Ala Ile Ser  Val Arg Leu Pro Asp  Asp Met Ser 
    3050                 3055                 3060             


Ala Leu  Gln Met Ala Ile Ile  Val Leu Ala Ile Leu  Leu Phe Leu 
    3065                 3070                 3075             


Ala Ala  Met Leu Phe Val Leu  Met Asn Trp Tyr Tyr  Arg Thr Val 
    3080                 3085                 3090             


His Lys  Arg Lys Leu Lys Ala  Ile Val Ala Gly Ser  Ala Gly Asn 
    3095                 3100                 3105             


Arg Gly  Phe Ile Asp Ile Met  Asp Met Pro Asn Thr  Asn Lys Tyr 
    3110                 3115                 3120             


Ser Phe  Asp Gly Ala Asn Pro  Val Trp Leu Asp Pro  Phe Cys Arg 
    3125                 3130                 3135             


Asn Leu  Glu Leu Ala Ala Gln  Ala Glu His Glu Asp  Asp Leu Pro 
    3140                 3145                 3150             


Glu Asn  Leu Ser Glu Ile Ala  Asp Leu Trp Asn Ser  Pro Thr Arg 
    3155                 3160                 3165             


Thr His  Gly Thr Phe Gly Arg  Glu Pro Ala Ala Val  Lys Pro Asp 
    3170                 3175                 3180             


Asp Asp  Arg Tyr Leu Arg Ala  Ala Ile Gln Glu Tyr  Asp Asn Ile 
    3185                 3190                 3195             


Ala Lys  Leu Gly Gln Ile Ile  Arg Glu Gly Pro Ile  Lys Gly Ser 
    3200                 3205                 3210             


Leu Leu  Lys Val Val Leu Glu  Asp Tyr Leu Arg Leu  Lys Lys Leu 
    3215                 3220                 3225             


Phe Ala  Gln Arg Met Val Gln  Lys Ala Ser Ser Cys  His Ser Ser 
    3230                 3235                 3240             


Ile Ser  Glu Leu Ile Gln Thr  Glu Leu Asp Glu Glu  Pro Gly Asp 
    3245                 3250                 3255             


His Ser  Pro Gly Gln Gly Ser  Leu Arg Phe Arg His  Lys Pro Pro 
    3260                 3265                 3270             


Val Glu  Leu Lys Gly Pro Asp  Gly Ile His Val Val  His Gly Ser 
    3275                 3280                 3285             


Thr Gly  Thr Leu Leu Ala Thr  Asp Leu Asn Ser Leu  Pro Glu Glu 
    3290                 3295                 3300             


Asp Gln  Lys Gly Leu Gly Arg  Ser Leu Glu Thr Leu  Thr Ala Ala 
    3305                 3310                 3315             


Glu Ala  Thr Ala Phe Glu Arg  Asn Ala Arg Thr Glu  Ser Ala Lys 
    3320                 3325                 3330             


Ser Thr  Pro Leu His Lys Leu  Arg Asp Val Ile Met  Glu Thr Pro 
    3335                 3340                 3345             


Leu Glu  Ile Thr Glu Leu 
    3350                 


<210>  2511
<211>  1061
<212>  PRT
<213>  Homo Sapiens

<400>  2511

Met Gly Arg His Val Ala Thr Ser Cys His Val Ala Trp Leu Leu Val 
1               5                   10                  15      


Leu Ile Ser Gly Cys Trp Gly Gln Val Asn Arg Leu Pro Phe Phe Thr 
            20                  25                  30          


Asn His Phe Phe Asp Thr Tyr Leu Leu Ile Ser Glu Asp Thr Pro Val 
        35                  40                  45              


Gly Ser Ser Val Thr Gln Leu Leu Ala Gln Asp Met Asp Asn Asp Pro 
    50                  55                  60                  


Leu Val Phe Gly Val Ser Gly Glu Glu Ala Ser Arg Phe Phe Ala Val 
65                  70                  75                  80  


Glu Pro Asp Thr Gly Val Val Trp Leu Arg Gln Pro Leu Asp Arg Glu 
                85                  90                  95      


Thr Lys Ser Glu Phe Thr Val Glu Phe Ser Val Ser Asp His Gln Gly 
            100                 105                 110         


Val Ile Thr Arg Lys Val Asn Ile Gln Val Gly Asp Val Asn Asp Asn 
        115                 120                 125             


Ala Pro Thr Phe His Asn Gln Pro Tyr Ser Val Arg Ile Pro Glu Asn 
    130                 135                 140                 


Thr Pro Val Gly Thr Pro Ile Phe Ile Val Asn Ala Thr Asp Pro Asp 
145                 150                 155                 160 


Leu Gly Ala Gly Gly Ser Val Leu Tyr Ser Phe Gln Pro Pro Ser Gln 
                165                 170                 175     


Phe Phe Ala Ile Asp Ser Ala Arg Gly Ile Val Thr Val Ile Arg Glu 
            180                 185                 190         


Leu Asp Tyr Glu Thr Thr Gln Ala Tyr Gln Leu Thr Val Asn Ala Thr 
        195                 200                 205             


Asp Gln Asp Lys Thr Arg Pro Leu Ser Thr Leu Ala Asn Leu Ala Ile 
    210                 215                 220                 


Ile Ile Thr Asp Val Gln Asp Met Asp Pro Ile Phe Ile Asn Leu Pro 
225                 230                 235                 240 


Tyr Ser Thr Asn Ile Tyr Glu His Ser Pro Pro Gly Thr Thr Val Arg 
                245                 250                 255     


Ile Ile Thr Ala Ile Asp Gln Asp Lys Gly Arg Pro Arg Gly Ile Gly 
            260                 265                 270         


Tyr Thr Ile Val Ser Gly Asn Thr Asn Ser Ile Phe Ala Leu Asp Tyr 
        275                 280                 285             


Ile Ser Gly Val Leu Thr Leu Asn Gly Leu Leu Asp Arg Glu Asn Pro 
    290                 295                 300                 


Leu Tyr Ser His Gly Phe Ile Leu Thr Val Lys Gly Thr Glu Leu Asn 
305                 310                 315                 320 


Asp Asp Arg Thr Pro Ser Asp Ala Thr Val Thr Thr Thr Phe Asn Ile 
                325                 330                 335     


Leu Val Ile Asp Ile Asn Asp Asn Ala Pro Glu Phe Asn Ser Ser Glu 
            340                 345                 350         


Tyr Ser Val Ala Ile Thr Glu Leu Ala Gln Val Gly Phe Ala Leu Pro 
        355                 360                 365             


Leu Phe Ile Gln Val Val Asp Lys Asp Glu Asn Leu Gly Leu Asn Ser 
    370                 375                 380                 


Met Phe Glu Val Tyr Leu Val Gly Asn Asn Ser His His Phe Ile Ile 
385                 390                 395                 400 


Ser Pro Thr Ser Val Gln Gly Lys Ala Asp Ile Arg Ile Arg Val Ala 
                405                 410                 415     


Ile Pro Leu Asp Tyr Glu Thr Val Asp Arg Tyr Asp Phe Asp Leu Phe 
            420                 425                 430         


Ala Asn Glu Ser Val Pro Asp His Val Gly Tyr Ala Lys Val Lys Ile 
        435                 440                 445             


Thr Leu Ile Asn Glu Asn Asp Asn Arg Pro Ile Phe Ser Gln Pro Leu 
    450                 455                 460                 


Tyr Asn Ile Ser Leu Tyr Glu Asn Val Thr Val Gly Thr Ser Val Leu 
465                 470                 475                 480 


Thr Val Leu Ala Thr Asp Asn Asp Ala Gly Thr Phe Gly Glu Val Ser 
                485                 490                 495     


Tyr Phe Phe Ser Asp Asp Pro Asp Arg Phe Ser Leu Asp Lys Asp Thr 
            500                 505                 510         


Gly Leu Ile Met Leu Ile Ala Arg Leu Asp Tyr Glu Leu Ile Gln Arg 
        515                 520                 525             


Phe Thr Leu Thr Ile Ile Ala Arg Asp Gly Gly Gly Glu Glu Thr Thr 
    530                 535                 540                 


Gly Arg Val Arg Ile Asn Val Leu Asp Val Asn Asp Asn Val Pro Thr 
545                 550                 555                 560 


Phe Gln Lys Asp Ala Tyr Val Gly Ala Leu Arg Glu Asn Glu Pro Ser 
                565                 570                 575     


Val Thr Gln Leu Val Arg Leu Arg Ala Thr Asp Glu Asp Ser Pro Pro 
            580                 585                 590         


Asn Asn Gln Ile Thr Tyr Ser Ile Val Ser Ala Ser Ala Phe Gly Ser 
        595                 600                 605             


Tyr Phe Asp Ile Ser Leu Tyr Glu Gly Tyr Gly Val Ile Ser Val Ser 
    610                 615                 620                 


Arg Pro Leu Asp Tyr Glu Gln Ile Ser Asn Gly Leu Ile Tyr Leu Thr 
625                 630                 635                 640 


Val Met Ala Met Asp Ala Gly Asn Pro Pro Leu Asn Ser Thr Val Pro 
                645                 650                 655     


Val Thr Ile Glu Val Phe Asp Glu Asn Asp Asn Pro Pro Thr Phe Ser 
            660                 665                 670         


Lys Pro Ala Tyr Phe Val Ser Val Val Glu Asn Ile Met Ala Gly Ala 
        675                 680                 685             


Thr Val Leu Phe Leu Asn Ala Thr Asp Leu Asp Arg Ser Arg Glu Tyr 
    690                 695                 700                 


Gly Gln Glu Ser Ile Ile Tyr Ser Leu Glu Gly Ser Thr Gln Phe Arg 
705                 710                 715                 720 


Ile Asn Ala Arg Ser Gly Glu Ile Thr Thr Thr Ser Leu Leu Asp Arg 
                725                 730                 735     


Glu Thr Lys Ser Glu Tyr Ile Leu Ile Val Arg Ala Val Asp Gly Gly 
            740                 745                 750         


Val Gly His Asn Gln Lys Thr Gly Ile Ala Thr Val Asn Ile Thr Leu 
        755                 760                 765             


Leu Asp Ile Asn Asp Asn His Pro Thr Trp Lys Asp Ala Pro Tyr Tyr 
    770                 775                 780                 


Ile Asn Leu Val Glu Met Thr Pro Pro Asp Ser Asp Val Thr Thr Val 
785                 790                 795                 800 


Val Ala Val Asp Pro Asp Leu Gly Glu Asn Gly Thr Leu Val Tyr Ser 
                805                 810                 815     


Ile Gln Pro Pro Asn Lys Phe Tyr Ser Leu Asn Ser Thr Thr Gly Lys 
            820                 825                 830         


Ile Arg Thr Thr His Ala Met Leu Asp Arg Glu Asn Pro Asp Pro His 
        835                 840                 845             


Glu Ala Glu Leu Met Arg Lys Ile Val Val Ser Val Thr Asp Cys Gly 
    850                 855                 860                 


Arg Pro Pro Leu Lys Ala Thr Ser Ser Ala Thr Val Phe Val Asn Leu 
865                 870                 875                 880 


Leu Asp Leu Asn Asp Asn Asp Pro Thr Phe Gln Asn Leu Pro Phe Val 
                885                 890                 895     


Ala Glu Val Leu Glu Gly Ile Pro Ala Gly Val Ser Ile Tyr Gln Val 
            900                 905                 910         


Val Ala Ile Asp Leu Asp Glu Gly Leu Asn Gly Leu Val Ser Tyr Arg 
        915                 920                 925             


Met Pro Val Gly Met Pro Arg Met Asp Phe Leu Ile Asn Ser Ser Ser 
    930                 935                 940                 


Gly Val Val Val Thr Thr Thr Glu Leu Asp Arg Glu Arg Ile Ala Glu 
945                 950                 955                 960 


Tyr Gln Leu Arg Val Val Ala Ser Asp Ala Gly Thr Pro Thr Lys Ser 
                965                 970                 975     


Ser Thr Ser Thr Leu Thr Ile His Val Leu Asp Val Asn Asp Glu Thr 
            980                 985                 990         


Pro Thr Phe Phe Pro Ala Val Tyr  Asn Val Ser Val Ser  Glu Asp Val 
        995                 1000                 1005             


Pro Arg  Glu Phe Arg Val Val  Trp Leu Asn Cys Thr  Asp Asn Asp 
    1010                 1015                 1020             


Val Gly  Leu Asn Ala Glu Leu  Ser Tyr Phe Ile Thr  Gly Ala Ala 
    1025                 1030                 1035             


Pro Ala  Ser Ala His Leu Cys  Arg Pro Pro Gly Ala  Leu Pro Pro 
    1040                 1045                 1050             


Pro Leu  Pro Asp Gly Gln Pro  Asp 
    1055                 1060     


<210>  2512
<211>  1380
<212>  PRT
<213>  Homo Sapiens

<400>  2512

Met Gly Arg His Val Ala Thr Ser Cys His Val Ala Trp Leu Leu Val 
1               5                   10                  15      


Leu Ile Ser Gly Cys Trp Gly Gln Val Asn Arg Leu Pro Phe Phe Thr 
            20                  25                  30          


Asn His Phe Phe Asp Thr Tyr Leu Leu Ile Ser Glu Asp Thr Pro Val 
        35                  40                  45              


Gly Ser Ser Val Thr Gln Leu Leu Ala Gln Asp Met Asp Asn Asp Pro 
    50                  55                  60                  


Leu Val Phe Gly Val Ser Gly Glu Glu Ala Ser Arg Phe Phe Ala Val 
65                  70                  75                  80  


Glu Pro Asp Thr Gly Val Val Trp Leu Arg Gln Pro Leu Asp Arg Glu 
                85                  90                  95      


Thr Lys Ser Glu Phe Thr Val Glu Phe Ser Val Ser Asp His Gln Gly 
            100                 105                 110         


Val Ile Thr Arg Lys Val Asn Ile Gln Val Gly Asp Val Asn Asp Asn 
        115                 120                 125             


Ala Pro Thr Phe His Asn Gln Pro Tyr Ser Val Arg Ile Pro Glu Asn 
    130                 135                 140                 


Thr Pro Val Gly Thr Pro Ile Phe Ile Val Asn Ala Thr Asp Pro Asp 
145                 150                 155                 160 


Leu Gly Ala Gly Gly Ser Val Leu Tyr Ser Phe Gln Pro Pro Ser Gln 
                165                 170                 175     


Phe Phe Ala Ile Asp Ser Ala Arg Gly Ile Val Thr Val Ile Arg Glu 
            180                 185                 190         


Leu Asp Tyr Glu Thr Thr Gln Ala Tyr Gln Leu Thr Val Asn Ala Thr 
        195                 200                 205             


Asp Gln Asp Lys Thr Arg Pro Leu Ser Thr Leu Ala Asn Leu Ala Ile 
    210                 215                 220                 


Ile Ile Thr Asp Val Gln Asp Met Asp Pro Ile Phe Ile Asn Leu Pro 
225                 230                 235                 240 


Tyr Ser Thr Asn Ile Tyr Glu His Ser Pro Pro Gly Thr Thr Val Arg 
                245                 250                 255     


Ile Ile Thr Ala Ile Asp Gln Asp Lys Gly Arg Pro Arg Gly Ile Gly 
            260                 265                 270         


Tyr Thr Ile Val Ser Gly Asn Thr Asn Ser Ile Phe Ala Leu Asp Tyr 
        275                 280                 285             


Ile Ser Gly Val Leu Thr Leu Asn Gly Leu Leu Asp Arg Glu Asn Pro 
    290                 295                 300                 


Leu Tyr Ser His Gly Phe Ile Leu Thr Val Lys Gly Thr Glu Leu Asn 
305                 310                 315                 320 


Asp Asp Arg Thr Pro Ser Asp Ala Thr Val Thr Thr Thr Phe Asn Ile 
                325                 330                 335     


Leu Val Ile Asp Ile Asn Asp Asn Ala Pro Glu Phe Asn Ser Ser Glu 
            340                 345                 350         


Tyr Ser Val Ala Ile Thr Glu Leu Ala Gln Val Gly Phe Ala Leu Pro 
        355                 360                 365             


Leu Phe Ile Gln Val Val Asp Lys Asp Glu Asn Leu Gly Leu Asn Ser 
    370                 375                 380                 


Met Phe Glu Val Tyr Leu Val Gly Asn Asn Ser His His Phe Ile Ile 
385                 390                 395                 400 


Ser Pro Thr Ser Val Gln Gly Lys Ala Asp Ile Arg Ile Arg Val Ala 
                405                 410                 415     


Ile Pro Leu Asp Tyr Glu Thr Val Asp Arg Tyr Asp Phe Asp Leu Phe 
            420                 425                 430         


Ala Asn Glu Ser Val Pro Asp His Val Gly Tyr Ala Lys Val Lys Ile 
        435                 440                 445             


Thr Leu Ile Asn Glu Asn Asp Asn Arg Pro Ile Phe Ser Gln Pro Leu 
    450                 455                 460                 


Tyr Asn Ile Ser Leu Tyr Glu Asn Val Thr Val Gly Thr Ser Val Leu 
465                 470                 475                 480 


Thr Val Leu Ala Thr Asp Asn Asp Ala Gly Thr Phe Gly Glu Val Ser 
                485                 490                 495     


Tyr Phe Phe Ser Asp Asp Pro Asp Arg Phe Ser Leu Asp Lys Asp Thr 
            500                 505                 510         


Gly Leu Ile Met Leu Ile Ala Arg Leu Asp Tyr Glu Leu Ile Gln Arg 
        515                 520                 525             


Phe Thr Leu Thr Ile Ile Ala Arg Asp Gly Gly Gly Glu Glu Thr Thr 
    530                 535                 540                 


Gly Arg Val Arg Ile Asn Val Leu Asp Val Asn Asp Asn Val Pro Thr 
545                 550                 555                 560 


Phe Gln Lys Asp Ala Tyr Val Gly Ala Leu Arg Glu Asn Glu Pro Ser 
                565                 570                 575     


Val Thr Gln Leu Val Arg Leu Arg Ala Thr Asp Glu Asp Ser Pro Pro 
            580                 585                 590         


Asn Asn Gln Ile Thr Tyr Ser Ile Val Ser Ala Ser Ala Phe Gly Ser 
        595                 600                 605             


Tyr Phe Asp Ile Ser Leu Tyr Glu Gly Tyr Gly Val Ile Ser Val Ser 
    610                 615                 620                 


Arg Pro Leu Asp Tyr Glu Gln Ile Ser Asn Gly Leu Ile Tyr Leu Thr 
625                 630                 635                 640 


Val Met Ala Met Asp Ala Gly Asn Pro Pro Leu Asn Ser Thr Val Pro 
                645                 650                 655     


Val Thr Ile Glu Val Phe Asp Glu Asn Asp Asn Pro Pro Thr Phe Ser 
            660                 665                 670         


Lys Pro Ala Tyr Phe Val Ser Val Val Glu Asn Ile Met Ala Gly Ala 
        675                 680                 685             


Thr Val Leu Phe Leu Asn Ala Thr Asp Leu Asp Arg Ser Arg Glu Tyr 
    690                 695                 700                 


Gly Gln Glu Ser Ile Ile Tyr Ser Leu Glu Gly Ser Thr Gln Phe Arg 
705                 710                 715                 720 


Ile Asn Ala Arg Ser Gly Glu Ile Thr Thr Thr Ser Leu Leu Asp Arg 
                725                 730                 735     


Glu Thr Lys Ser Glu Tyr Ile Leu Ile Val Arg Ala Val Asp Gly Gly 
            740                 745                 750         


Val Gly His Asn Gln Lys Thr Gly Ile Ala Thr Val Asn Ile Thr Leu 
        755                 760                 765             


Leu Asp Ile Asn Asp Asn His Pro Thr Trp Lys Asp Ala Pro Tyr Tyr 
    770                 775                 780                 


Ile Asn Leu Val Glu Met Thr Pro Pro Asp Ser Asp Val Thr Thr Val 
785                 790                 795                 800 


Val Ala Val Asp Pro Asp Leu Gly Glu Asn Gly Thr Leu Val Tyr Ser 
                805                 810                 815     


Ile Gln Pro Pro Asn Lys Phe Tyr Ser Leu Asn Ser Thr Thr Gly Lys 
            820                 825                 830         


Ile Arg Thr Thr His Ala Met Leu Asp Arg Glu Asn Pro Asp Pro His 
        835                 840                 845             


Glu Ala Glu Leu Met Arg Lys Ile Val Val Ser Val Thr Asp Cys Gly 
    850                 855                 860                 


Arg Pro Pro Leu Lys Ala Thr Ser Ser Ala Thr Val Phe Val Asn Leu 
865                 870                 875                 880 


Leu Asp Leu Asn Asp Asn Asp Pro Thr Phe Gln Asn Leu Pro Phe Val 
                885                 890                 895     


Ala Glu Val Leu Glu Gly Ile Pro Ala Gly Val Ser Ile Tyr Gln Val 
            900                 905                 910         


Val Ala Ile Asp Leu Asp Glu Gly Leu Asn Gly Leu Val Ser Tyr Arg 
        915                 920                 925             


Met Pro Val Gly Met Pro Arg Met Asp Phe Leu Ile Asn Ser Ser Ser 
    930                 935                 940                 


Gly Val Val Val Thr Thr Thr Glu Leu Asp Arg Glu Arg Ile Ala Glu 
945                 950                 955                 960 


Tyr Gln Leu Arg Val Val Ala Ser Asp Ala Gly Thr Pro Thr Lys Ser 
                965                 970                 975     


Ser Thr Ser Thr Leu Thr Ile His Val Leu Asp Val Asn Asp Glu Thr 
            980                 985                 990         


Pro Thr Phe Phe Pro Ala Val Tyr  Asn Val Ser Val Ser  Glu Asp Val 
        995                 1000                 1005             


Pro Arg  Glu Phe Arg Val Val  Trp Leu Asn Cys Thr  Asp Asn Asp 
    1010                 1015                 1020             


Val Gly  Leu Asn Ala Glu Leu  Ser Tyr Phe Ile Thr  Gly Gly Asn 
    1025                 1030                 1035             


Val Asp  Gly Lys Phe Ser Val  Gly Tyr Arg Asp Ala  Val Val Arg 
    1040                 1045                 1050             


Thr Val  Val Gly Leu Asp Arg  Glu Thr Thr Ala Ala  Tyr Met Leu 
    1055                 1060                 1065             


Ile Leu  Glu Ala Ile Asp Asn  Gly Pro Val Gly Lys  Arg His Thr 
    1070                 1075                 1080             


Gly Thr  Ala Thr Val Phe Val  Thr Val Leu Asp Val  Asn Asp Asn 
    1085                 1090                 1095             


Arg Pro  Ile Phe Leu Gln Ser  Ser Tyr Glu Ala Ser  Val Pro Glu 
    1100                 1105                 1110             


Asp Ile  Pro Glu Gly His Ser  Ile Leu Gln Ala Ala  Thr Asp Ala 
    1115                 1120                 1125             


Asp Glu  Gly Glu Phe Gly Arg  Val Trp Tyr Arg Ile  Leu His Gly 
    1130                 1135                 1140             


Asn His  Gly Asn Asn Phe Arg  Ile His Val Ser Asn  Gly Leu Leu 
    1145                 1150                 1155             


Met Arg  Gly Pro Arg Pro Leu  Asp Arg Glu Arg Asn  Ser Ser His 
    1160                 1165                 1170             


Val Leu  Ile Val Glu Ala Tyr  Asn His Asp Leu Gly  Pro Met Arg 
    1175                 1180                 1185             


Ser Ser  Val Arg Val Ile Val  Tyr Val Glu Asp Ile  Asn Asp Glu 
    1190                 1195                 1200             


Ala Pro  Val Phe Thr Gln Gln  Gln Tyr Ser Arg Leu  Gly Leu Arg 
    1205                 1210                 1215             


Glu Thr  Ala Gly Ile Gly Thr  Ser Val Ile Val Val  Gln Ala Thr 
    1220                 1225                 1230             


Asp Arg  Asp Ser Gly Asp Gly  Gly Leu Val Asn Tyr  Arg Ile Leu 
    1235                 1240                 1245             


Ser Gly  Ala Glu Gly Lys Phe  Glu Ile Asp Glu Ser  Thr Gly Leu 
    1250                 1255                 1260             


Ile Ile  Thr Val Asn Tyr Leu  Asp Tyr Glu Thr Lys  Thr Ser Tyr 
    1265                 1270                 1275             


Met Met  Asn Val Ser Ala Thr  Asp Gln Ala Pro Pro  Phe Asn Gln 
    1280                 1285                 1290             


Gly Phe  Cys Ser Val Tyr Ile  Thr Leu Leu Asn Glu  Leu Asp Glu 
    1295                 1300                 1305             


Ala Val  Gln Phe Ser Asn Ala  Ser Tyr Glu Ala Ala  Ile Leu Glu 
    1310                 1315                 1320             


Asn Leu  Ala Leu Gly Thr Glu  Ile Val Arg Val Gln  Ala Tyr Ser 
    1325                 1330                 1335             


Ile Asp  Asn Leu Asn Gln Ile  Thr Tyr Arg Phe Asn  Ala Tyr Thr 
    1340                 1345                 1350             


Ser Thr  Gln Ala Lys Ala Leu  Phe Lys Ile Asp Ala  Ile Thr Val 
    1355                 1360                 1365             


Arg Gly  Trp Gly Gln Gly Ala  Pro Phe Leu Pro Ile  
    1370                 1375                 1380 


<210>  2513
<211>  1211
<212>  PRT
<213>  Homo Sapiens

<400>  2513

Met Gly Arg His Val Ala Thr Ser Cys His Val Ala Trp Leu Leu Val 
1               5                   10                  15      


Leu Ile Ser Gly Cys Trp Gly Gln Val Asn Arg Leu Pro Phe Phe Thr 
            20                  25                  30          


Asn His Phe Phe Asp Thr Tyr Leu Leu Ile Ser Glu Asp Thr Pro Val 
        35                  40                  45              


Gly Ser Ser Val Thr Gln Leu Leu Ala Gln Asp Met Asp Asn Asp Pro 
    50                  55                  60                  


Leu Val Phe Gly Val Ser Gly Glu Glu Ala Ser Arg Phe Phe Ala Val 
65                  70                  75                  80  


Glu Pro Asp Thr Gly Val Val Trp Leu Arg Gln Pro Leu Asp Arg Glu 
                85                  90                  95      


Thr Lys Ser Glu Phe Thr Val Glu Phe Ser Val Ser Asp His Gln Gly 
            100                 105                 110         


Val Ile Thr Arg Lys Val Asn Ile Gln Val Gly Asp Val Asn Asp Asn 
        115                 120                 125             


Ala Pro Thr Phe His Asn Gln Pro Tyr Ser Val Arg Ile Pro Glu Asn 
    130                 135                 140                 


Thr Pro Val Gly Thr Pro Ile Phe Ile Val Asn Ala Thr Asp Pro Asp 
145                 150                 155                 160 


Leu Gly Ala Gly Gly Ser Val Leu Tyr Ser Phe Gln Pro Pro Ser Gln 
                165                 170                 175     


Phe Phe Ala Ile Asp Ser Ala Arg Gly Ile Val Thr Val Ile Arg Glu 
            180                 185                 190         


Leu Asp Tyr Glu Thr Thr Gln Ala Tyr Gln Leu Thr Val Asn Ala Thr 
        195                 200                 205             


Asp Gln Asp Lys Thr Arg Pro Leu Ser Thr Leu Ala Asn Leu Ala Ile 
    210                 215                 220                 


Ile Ile Thr Asp Val Gln Asp Met Asp Pro Ile Phe Ile Asn Leu Pro 
225                 230                 235                 240 


Tyr Ser Thr Asn Ile Tyr Glu His Ser Pro Pro Gly Thr Thr Val Arg 
                245                 250                 255     


Ile Ile Thr Ala Ile Asp Gln Asp Lys Gly Arg Pro Arg Gly Ile Gly 
            260                 265                 270         


Tyr Thr Ile Val Ser Gly Asn Thr Asn Ser Ile Phe Ala Leu Asp Tyr 
        275                 280                 285             


Ile Ser Gly Val Leu Thr Leu Asn Gly Leu Leu Asp Arg Glu Asn Pro 
    290                 295                 300                 


Leu Tyr Ser His Gly Phe Ile Leu Thr Val Lys Gly Thr Glu Leu Asn 
305                 310                 315                 320 


Asp Asp Arg Thr Pro Ser Asp Ala Thr Val Thr Thr Thr Phe Asn Ile 
                325                 330                 335     


Leu Val Ile Asp Ile Asn Asp Asn Ala Pro Glu Phe Asn Ser Ser Glu 
            340                 345                 350         


Tyr Ser Val Ala Ile Thr Glu Leu Ala Gln Val Gly Phe Ala Leu Pro 
        355                 360                 365             


Leu Phe Ile Gln Val Val Asp Lys Asp Glu Asn Leu Gly Leu Asn Ser 
    370                 375                 380                 


Met Phe Glu Val Tyr Leu Val Gly Asn Asn Ser His His Phe Ile Ile 
385                 390                 395                 400 


Ser Pro Thr Ser Val Gln Gly Lys Ala Asp Ile Arg Ile Arg Val Ala 
                405                 410                 415     


Ile Pro Leu Asp Tyr Glu Thr Val Asp Arg Tyr Asp Phe Asp Leu Phe 
            420                 425                 430         


Ala Asn Glu Ser Val Pro Asp His Val Gly Tyr Ala Lys Val Lys Ile 
        435                 440                 445             


Thr Leu Ile Asn Glu Asn Asp Asn Arg Pro Ile Phe Ser Gln Pro Leu 
    450                 455                 460                 


Tyr Asn Ile Ser Leu Tyr Glu Asn Val Thr Val Gly Thr Ser Val Leu 
465                 470                 475                 480 


Thr Val Leu Ala Thr Asp Asn Asp Ala Gly Thr Phe Gly Glu Val Ser 
                485                 490                 495     


Tyr Phe Phe Ser Asp Asp Pro Asp Arg Phe Ser Leu Asp Lys Asp Thr 
            500                 505                 510         


Gly Leu Ile Met Leu Ile Ala Arg Leu Asp Tyr Glu Leu Ile Gln Arg 
        515                 520                 525             


Phe Thr Leu Thr Ile Ile Ala Arg Asp Gly Gly Gly Glu Glu Thr Thr 
    530                 535                 540                 


Gly Arg Val Arg Ile Asn Val Leu Asp Val Asn Asp Asn Val Pro Thr 
545                 550                 555                 560 


Phe Gln Lys Asp Ala Tyr Val Gly Ala Leu Arg Glu Asn Glu Pro Ser 
                565                 570                 575     


Val Thr Gln Leu Val Arg Leu Arg Ala Thr Asp Glu Asp Ser Pro Pro 
            580                 585                 590         


Asn Asn Gln Ile Thr Tyr Ser Ile Val Ser Ala Ser Ala Phe Gly Ser 
        595                 600                 605             


Tyr Phe Asp Ile Ser Leu Tyr Glu Gly Tyr Gly Val Ile Ser Val Ser 
    610                 615                 620                 


Arg Pro Leu Asp Tyr Glu Gln Ile Ser Asn Gly Leu Ile Tyr Leu Thr 
625                 630                 635                 640 


Val Met Ala Met Asp Ala Gly Asn Pro Pro Leu Asn Ser Thr Val Pro 
                645                 650                 655     


Val Thr Ile Glu Val Phe Asp Glu Asn Asp Asn Pro Pro Thr Phe Ser 
            660                 665                 670         


Lys Pro Ala Tyr Phe Val Ser Val Val Glu Asn Ile Met Ala Gly Ala 
        675                 680                 685             


Thr Val Leu Phe Leu Asn Ala Thr Asp Leu Asp Arg Ser Arg Glu Tyr 
    690                 695                 700                 


Gly Gln Glu Ser Ile Ile Tyr Ser Leu Glu Gly Ser Thr Gln Phe Arg 
705                 710                 715                 720 


Ile Asn Ala Arg Ser Gly Glu Ile Thr Thr Thr Ser Leu Leu Asp Arg 
                725                 730                 735     


Glu Thr Lys Ser Glu Tyr Ile Leu Ile Val Arg Ala Val Asp Gly Gly 
            740                 745                 750         


Val Gly His Asn Gln Lys Thr Gly Ile Ala Thr Val Asn Ile Thr Leu 
        755                 760                 765             


Leu Asp Ile Asn Asp Asn His Pro Thr Trp Lys Asp Ala Pro Tyr Tyr 
    770                 775                 780                 


Ile Asn Leu Val Glu Met Thr Pro Pro Asp Ser Asp Val Thr Thr Val 
785                 790                 795                 800 


Val Ala Val Asp Pro Asp Leu Gly Glu Asn Gly Thr Leu Val Tyr Ser 
                805                 810                 815     


Ile Gln Pro Pro Asn Lys Phe Tyr Ser Leu Asn Ser Thr Thr Gly Lys 
            820                 825                 830         


Ile Arg Thr Thr His Ala Met Leu Asp Arg Glu Asn Pro Asp Pro His 
        835                 840                 845             


Glu Ala Glu Leu Met Arg Lys Ile Val Val Ser Val Thr Asp Cys Gly 
    850                 855                 860                 


Arg Pro Pro Leu Lys Ala Thr Ser Ser Ala Thr Val Phe Val Asn Leu 
865                 870                 875                 880 


Leu Asp Leu Asn Asp Asn Asp Pro Thr Phe Gln Asn Leu Pro Phe Val 
                885                 890                 895     


Ala Glu Val Leu Glu Gly Ile Pro Ala Gly Val Ser Ile Tyr Gln Val 
            900                 905                 910         


Val Ala Ile Asp Leu Asp Glu Gly Leu Asn Gly Leu Val Ser Tyr Arg 
        915                 920                 925             


Met Pro Val Gly Met Pro Arg Met Asp Phe Leu Ile Asn Ser Ser Ser 
    930                 935                 940                 


Gly Val Val Val Thr Thr Thr Glu Leu Asp Arg Glu Arg Ile Ala Glu 
945                 950                 955                 960 


Tyr Gln Leu Arg Val Val Ala Ser Asp Ala Gly Thr Pro Thr Lys Ser 
                965                 970                 975     


Ser Thr Ser Thr Leu Thr Ile His Val Leu Asp Val Asn Asp Glu Thr 
            980                 985                 990         


Pro Thr Phe Phe Pro Ala Val Tyr  Asn Val Ser Val Ser  Glu Asp Val 
        995                 1000                 1005             


Pro Arg  Glu Phe Arg Val Val  Trp Leu Asn Cys Thr  Asp Asn Asp 
    1010                 1015                 1020             


Val Gly  Leu Asn Ala Glu Leu  Ser Tyr Phe Ile Thr  Gly Gly Asn 
    1025                 1030                 1035             


Val Asp  Gly Lys Phe Ser Val  Gly Tyr Arg Asp Ala  Val Val Arg 
    1040                 1045                 1050             


Thr Val  Val Gly Leu Asp Arg  Glu Thr Thr Ala Ala  Tyr Met Leu 
    1055                 1060                 1065             


Ile Leu  Glu Ala Ile Asp Asn  Gly Pro Val Gly Lys  Arg His Thr 
    1070                 1075                 1080             


Gly Thr  Ala Thr Val Phe Val  Thr Val Leu Asp Val  Asn Asp Asn 
    1085                 1090                 1095             


Arg Pro  Ile Phe Leu Gln Ser  Ser Tyr Glu Ala Ser  Val Pro Glu 
    1100                 1105                 1110             


Asp Ile  Pro Glu Gly His Ser  Ile Leu Gln Glu Asp  Leu Ala Ser 
    1115                 1120                 1125             


Pro Cys  Ile Ser Pro Ala Pro  Pro Arg Arg Ala Phe  Gln Ser Ser 
    1130                 1135                 1140             


Gly Glu  Lys Glu Thr Ser Gln  Phe Pro Gly Lys Glu  Leu Arg Arg 
    1145                 1150                 1155             


Glu Pro  Gly Pro Ser Lys Ala  Gln Asn Arg Ala Ala  Phe Thr Glu 
    1160                 1165                 1170             


Pro Leu  Ala Glu Ala Pro Leu  Leu Gly Ser Lys Gln  Ala Gln Glu 
    1175                 1180                 1185             


Glu Arg  Ala Pro Leu Pro Arg  Glu Gln Ala Gln Gln  Leu Gln Gly 
    1190                 1195                 1200             


Ser Glu  Gly Glu Lys Gly Gly  Pro 
    1205                 1210     


<210>  2514
<211>  530
<212>  PRT
<213>  Homo Sapiens

<400>  2514

Met Gly Arg His Val Ala Thr Ser Cys His Val Ala Trp Leu Leu Val 
1               5                   10                  15      


Leu Ile Ser Gly Cys Trp Gly Gln Val Asn Arg Leu Pro Phe Phe Thr 
            20                  25                  30          


Asn His Phe Phe Asp Thr Tyr Leu Leu Ile Ser Glu Asp Thr Pro Val 
        35                  40                  45              


Gly Ser Ser Val Thr Gln Leu Leu Ala Gln Asp Met Asp Asn Asp Pro 
    50                  55                  60                  


Leu Val Phe Gly Val Ser Gly Glu Glu Ala Ser Arg Phe Phe Ala Val 
65                  70                  75                  80  


Glu Pro Asp Thr Gly Val Val Trp Leu Arg Gln Pro Leu Asp Arg Glu 
                85                  90                  95      


Thr Lys Ser Glu Phe Thr Val Glu Phe Ser Val Ser Asp His Gln Gly 
            100                 105                 110         


Val Ile Thr Arg Lys Val Asn Ile Gln Val Gly Asp Val Asn Asp Asn 
        115                 120                 125             


Ala Pro Thr Phe His Asn Gln Pro Tyr Ser Val Arg Ile Pro Glu Asn 
    130                 135                 140                 


Thr Pro Val Gly Thr Pro Ile Phe Ile Val Asn Ala Thr Asp Pro Asp 
145                 150                 155                 160 


Leu Gly Ala Gly Gly Ser Val Leu Tyr Ser Phe Gln Pro Pro Ser Gln 
                165                 170                 175     


Phe Phe Ala Ile Asp Ser Ala Arg Gly Ile Val Thr Val Ile Arg Glu 
            180                 185                 190         


Leu Asp Tyr Glu Thr Thr Gln Ala Tyr Gln Leu Thr Val Asn Ala Thr 
        195                 200                 205             


Asp Gln Asp Lys Thr Arg Pro Leu Ser Thr Leu Ala Asn Leu Ala Ile 
    210                 215                 220                 


Ile Ile Thr Asp Val Gln Asp Met Asp Pro Ile Phe Ile Asn Leu Pro 
225                 230                 235                 240 


Tyr Ser Thr Asn Ile Tyr Glu His Ser Pro Pro Gly Thr Thr Val Arg 
                245                 250                 255     


Ile Ile Thr Ala Ile Asp Gln Asp Lys Gly Arg Pro Arg Gly Ile Gly 
            260                 265                 270         


Tyr Thr Ile Val Ser Gly Asn Thr Asn Ser Ile Phe Ala Leu Asp Tyr 
        275                 280                 285             


Ile Ser Gly Val Leu Thr Leu Asn Gly Leu Leu Asp Arg Glu Asn Pro 
    290                 295                 300                 


Leu Tyr Ser His Gly Phe Ile Leu Thr Val Lys Gly Thr Glu Leu Asn 
305                 310                 315                 320 


Asp Asp Arg Thr Pro Ser Asp Ala Thr Val Thr Thr Thr Phe Asn Ile 
                325                 330                 335     


Leu Val Ile Asp Ile Asn Asp Asn Ala Pro Glu Phe Asn Ser Ser Glu 
            340                 345                 350         


Tyr Ser Val Ala Ile Thr Glu Leu Ala Gln Val Gly Phe Ala Leu Pro 
        355                 360                 365             


Leu Phe Ile Gln Val Val Asp Lys Asp Glu Asn Leu Gly Leu Asn Ser 
    370                 375                 380                 


Met Phe Glu Val Tyr Leu Val Gly Asn Asn Ser His His Phe Ile Ile 
385                 390                 395                 400 


Ser Pro Thr Ser Val Gln Gly Lys Ala Asp Ile Arg Ile Arg Val Ala 
                405                 410                 415     


Ile Pro Leu Asp Tyr Glu Thr Val Asp Arg Tyr Asp Phe Asp Leu Phe 
            420                 425                 430         


Ala Asn Glu Ser Val Pro Asp His Val Gly Tyr Ala Lys Val Lys Ile 
        435                 440                 445             


Thr Leu Ile Asn Glu Asn Asp Asn Arg Pro Ile Phe Ser Gln Pro Leu 
    450                 455                 460                 


Tyr Asn Ile Ser Leu Tyr Glu Asn Val Thr Val Gly Thr Ser Val Leu 
465                 470                 475                 480 


Thr Val Leu Val Ser Pro Arg Phe Thr Ala Gly Pro Leu Ser Ser Pro 
                485                 490                 495     


Gly Pro Thr Val Val Arg His Pro Glu Gly Phe Cys Pro Arg Asp Leu 
            500                 505                 510         


Ser Asn Gln Gly Arg Arg His Pro Gln Ile Pro Glu Leu Cys Leu Leu 
        515                 520                 525             


Val Tyr 
    530 


<210>  2515
<211>  3354
<212>  PRT
<213>  Homo Sapiens

<400>  2515

Met Gly Arg His Val Ala Thr Ser Cys His Val Ala Trp Leu Leu Val 
1               5                   10                  15      


Leu Ile Ser Gly Cys Trp Gly Gln Val Asn Arg Leu Pro Phe Phe Thr 
            20                  25                  30          


Asn His Phe Phe Asp Thr Tyr Leu Leu Ile Ser Glu Asp Thr Pro Val 
        35                  40                  45              


Gly Ser Ser Val Thr Gln Leu Leu Ala Gln Asp Met Asp Asn Asp Pro 
    50                  55                  60                  


Leu Val Phe Gly Val Ser Gly Glu Glu Ala Ser Arg Phe Phe Ala Val 
65                  70                  75                  80  


Glu Pro Asp Thr Gly Val Val Trp Leu Arg Gln Pro Leu Asp Arg Glu 
                85                  90                  95      


Thr Lys Ser Glu Phe Thr Val Glu Phe Ser Val Ser Asp His Gln Gly 
            100                 105                 110         


Val Ile Thr Arg Lys Val Asn Ile Gln Val Gly Asp Val Asn Asp Asn 
        115                 120                 125             


Ala Pro Thr Phe His Asn Gln Pro Tyr Ser Val Arg Ile Pro Glu Asn 
    130                 135                 140                 


Thr Pro Val Gly Thr Pro Ile Phe Ile Val Asn Ala Thr Asp Pro Asp 
145                 150                 155                 160 


Leu Gly Ala Gly Gly Ser Val Leu Tyr Ser Phe Gln Pro Pro Ser Gln 
                165                 170                 175     


Phe Phe Ala Ile Asp Ser Ala Arg Gly Ile Val Thr Val Ile Arg Glu 
            180                 185                 190         


Leu Asp Tyr Glu Thr Thr Gln Ala Tyr Gln Leu Thr Val Asn Ala Thr 
        195                 200                 205             


Asp Gln Asp Lys Thr Arg Pro Leu Ser Thr Leu Ala Asn Leu Ala Ile 
    210                 215                 220                 


Ile Ile Thr Asp Val Gln Asp Met Asp Pro Ile Phe Ile Asn Leu Pro 
225                 230                 235                 240 


Tyr Ser Thr Asn Ile Tyr Glu His Ser Pro Pro Gly Thr Thr Val Arg 
                245                 250                 255     


Ile Ile Thr Ala Ile Asp Gln Asp Lys Gly Arg Pro Arg Gly Ile Gly 
            260                 265                 270         


Tyr Thr Ile Val Ser Gly Asn Thr Asn Ser Ile Phe Ala Leu Asp Tyr 
        275                 280                 285             


Ile Ser Gly Val Leu Thr Leu Asn Gly Leu Leu Asp Arg Glu Asn Pro 
    290                 295                 300                 


Leu Tyr Ser His Gly Phe Ile Leu Thr Val Lys Gly Thr Glu Leu Asn 
305                 310                 315                 320 


Asp Asp Arg Thr Pro Ser Asp Ala Thr Val Thr Thr Thr Phe Asn Ile 
                325                 330                 335     


Leu Val Ile Asp Ile Asn Asp Asn Ala Pro Glu Phe Asn Ser Ser Glu 
            340                 345                 350         


Tyr Ser Val Ala Ile Thr Glu Leu Ala Gln Val Gly Phe Ala Leu Pro 
        355                 360                 365             


Leu Phe Ile Gln Val Val Asp Lys Asp Glu Thr Gln Gly Leu Asn Ser 
    370                 375                 380                 


Met Phe Glu Val Tyr Leu Val Gly Asn Asn Ser His His Phe Ile Ile 
385                 390                 395                 400 


Ser Pro Thr Ser Val Gln Gly Lys Ala Asp Ile Arg Ile Arg Val Ala 
                405                 410                 415     


Ile Pro Leu Asp Tyr Glu Thr Val Asp Arg Tyr Asp Phe Asp Leu Phe 
            420                 425                 430         


Ala Asn Glu Ser Val Pro Asp His Val Gly Tyr Ala Lys Val Lys Ile 
        435                 440                 445             


Thr Leu Ile Asn Glu Asn Asp Asn Arg Pro Ile Phe Ser Gln Pro Leu 
    450                 455                 460                 


Tyr Asn Ile Ser Leu Tyr Glu Asn Val Thr Val Gly Thr Ser Val Leu 
465                 470                 475                 480 


Thr Val Leu Ala Thr Asp Asn Asp Ala Gly Thr Phe Gly Glu Val Ser 
                485                 490                 495     


Tyr Phe Phe Ser Asp Asp Pro Asp Arg Phe Ser Leu Asp Lys Asp Thr 
            500                 505                 510         


Gly Leu Ile Met Leu Ile Ala Arg Leu Asp Tyr Glu Leu Ile Gln Arg 
        515                 520                 525             


Phe Thr Leu Thr Ile Ile Ala Arg Asp Gly Gly Gly Glu Glu Thr Thr 
    530                 535                 540                 


Gly Arg Val Arg Ile Asn Val Leu Asp Val Asn Asp Asn Val Pro Thr 
545                 550                 555                 560 


Phe Gln Lys Asp Ala Tyr Val Gly Ala Leu Arg Glu Asn Glu Pro Ser 
                565                 570                 575     


Val Thr Gln Leu Val Arg Leu Arg Ala Thr Asp Glu Asp Ser Pro Pro 
            580                 585                 590         


Asn Asn Gln Ile Thr Tyr Ser Ile Val Ser Ala Ser Ala Phe Gly Ser 
        595                 600                 605             


Tyr Phe Asp Ile Ser Leu Tyr Glu Gly Tyr Gly Val Ile Ser Val Ser 
    610                 615                 620                 


Arg Pro Leu Asp Tyr Glu Gln Ile Ser Asn Gly Leu Ile Tyr Leu Thr 
625                 630                 635                 640 


Val Met Ala Met Asp Ala Gly Asn Pro Pro Leu Asn Ser Thr Val Pro 
                645                 650                 655     


Val Thr Ile Glu Val Phe Asp Glu Asn Asp Asn Pro Pro Thr Phe Ser 
            660                 665                 670         


Lys Pro Ala Tyr Phe Val Ser Val Val Glu Asn Ile Met Ala Gly Ala 
        675                 680                 685             


Thr Val Leu Phe Leu Asn Ala Thr Asp Leu Asp Arg Ser Arg Glu Tyr 
    690                 695                 700                 


Gly Gln Glu Ser Ile Ile Tyr Ser Leu Glu Gly Ser Thr Gln Phe Arg 
705                 710                 715                 720 


Ile Asn Ala Arg Ser Gly Glu Ile Thr Thr Thr Ser Leu Leu Asp Arg 
                725                 730                 735     


Glu Thr Lys Ser Glu Tyr Ile Leu Ile Val Arg Ala Val Asp Gly Gly 
            740                 745                 750         


Val Gly His Asn Gln Lys Thr Gly Ile Ala Thr Val Asn Ile Thr Leu 
        755                 760                 765             


Leu Asp Ile Asn Asp Asn His Pro Thr Trp Lys Asp Ala Pro Tyr Tyr 
    770                 775                 780                 


Ile Asn Leu Val Glu Met Thr Pro Pro Asp Ser Asp Val Thr Thr Val 
785                 790                 795                 800 


Val Ala Val Asp Pro Asp Leu Gly Glu Asn Gly Thr Leu Val Tyr Ser 
                805                 810                 815     


Ile Gln Pro Pro Asn Lys Phe Tyr Ser Leu Asn Ser Thr Thr Gly Lys 
            820                 825                 830         


Ile Arg Thr Thr His Ala Met Leu Asp Arg Glu Asn Pro Asp Pro His 
        835                 840                 845             


Glu Ala Glu Leu Met Arg Lys Ile Val Val Ser Val Thr Asp Cys Gly 
    850                 855                 860                 


Arg Pro Pro Leu Lys Ala Thr Ser Ser Ala Thr Val Phe Val Asn Leu 
865                 870                 875                 880 


Leu Asp Leu Asn Asp Asn Asp Pro Thr Phe Gln Asn Leu Pro Phe Val 
                885                 890                 895     


Ala Glu Val Leu Glu Gly Ile Pro Ala Gly Val Ser Ile Tyr Gln Val 
            900                 905                 910         


Val Ala Ile Asp Leu Asp Glu Gly Leu Asn Gly Leu Val Ser Tyr Arg 
        915                 920                 925             


Met Pro Val Gly Met Pro Arg Met Asp Phe Leu Ile Asn Ser Ser Ser 
    930                 935                 940                 


Gly Val Val Val Thr Thr Thr Glu Leu Asp Arg Glu Arg Ile Ala Glu 
945                 950                 955                 960 


Tyr Gln Leu Arg Val Val Ala Ser Asp Ala Gly Thr Pro Thr Lys Ser 
                965                 970                 975     


Ser Thr Ser Thr Leu Thr Ile His Val Leu Asp Val Asn Asp Glu Thr 
            980                 985                 990         


Pro Thr Phe Phe Pro Ala Val Tyr  Asn Val Ser Val Ser  Glu Asp Val 
        995                 1000                 1005             


Pro Arg  Glu Phe Arg Val Val  Trp Leu Asn Cys Thr  Asp Asn Asp 
    1010                 1015                 1020             


Val Gly  Leu Asn Ala Glu Leu  Ser Tyr Phe Ile Thr  Gly Gly Asn 
    1025                 1030                 1035             


Val Asp  Gly Lys Phe Ser Val  Gly Tyr Arg Asp Ala  Val Val Arg 
    1040                 1045                 1050             


Thr Val  Val Gly Leu Asp Arg  Glu Thr Thr Ala Ala  Tyr Met Leu 
    1055                 1060                 1065             


Ile Leu  Glu Ala Ile Asp Asn  Gly Pro Val Gly Lys  Arg His Thr 
    1070                 1075                 1080             


Gly Thr  Ala Thr Val Phe Val  Thr Val Leu Asp Val  Asn Asp Asn 
    1085                 1090                 1095             


Arg Pro  Ile Phe Leu Gln Ser  Ser Tyr Glu Ala Ser  Val Pro Glu 
    1100                 1105                 1110             


Asp Ile  Pro Glu Gly His Ser  Ile Leu Gln Leu Lys  Ala Thr Asp 
    1115                 1120                 1125             


Ala Asp  Glu Gly Glu Phe Gly  Arg Val Trp Tyr Arg  Ile Leu His 
    1130                 1135                 1140             


Gly Asn  His Gly Asn Asn Phe  Arg Ile His Val Ser  Asn Gly Leu 
    1145                 1150                 1155             


Leu Met  Arg Gly Pro Arg Pro  Leu Asp Arg Glu Arg  Asn Ser Ser 
    1160                 1165                 1170             


His Val  Leu Ile Val Glu Ala  Tyr Asn His Asp Leu  Gly Pro Met 
    1175                 1180                 1185             


Arg Ser  Ser Val Arg Val Ile  Val Tyr Val Glu Asp  Ile Asn Asp 
    1190                 1195                 1200             


Glu Ala  Pro Val Phe Thr Gln  Gln Gln Tyr Ser Arg  Leu Gly Leu 
    1205                 1210                 1215             


Arg Glu  Thr Ala Gly Ile Gly  Thr Ser Val Ile Val  Val Gln Ala 
    1220                 1225                 1230             


Thr Asp  Arg Asp Ser Gly Asp  Gly Gly Leu Val Asn  Tyr Arg Ile 
    1235                 1240                 1245             


Leu Ser  Gly Ala Glu Gly Lys  Phe Glu Ile Asp Glu  Ser Thr Gly 
    1250                 1255                 1260             


Leu Ile  Ile Thr Val Asn Tyr  Leu Asp Tyr Glu Thr  Lys Thr Ser 
    1265                 1270                 1275             


Tyr Met  Met Asn Val Ser Ala  Thr Asp Gln Ala Pro  Pro Phe Asn 
    1280                 1285                 1290             


Gln Gly  Phe Cys Ser Val Tyr  Ile Thr Leu Leu Asn  Glu Leu Asp 
    1295                 1300                 1305             


Glu Ala  Val Gln Phe Ser Asn  Ala Ser Tyr Glu Ala  Ala Ile Leu 
    1310                 1315                 1320             


Glu Asn  Leu Ala Leu Gly Thr  Glu Ile Val Arg Val  Gln Ala Tyr 
    1325                 1330                 1335             


Ser Ile  Asp Asn Leu Asn Gln  Ile Thr Tyr Arg Phe  Asn Ala Tyr 
    1340                 1345                 1350             


Thr Ser  Thr Gln Ala Lys Ala  Leu Phe Lys Ile Asp  Ala Ile Thr 
    1355                 1360                 1365             


Gly Val  Ile Thr Val Gln Gly  Leu Val Asp Arg Glu  Lys Gly Asp 
    1370                 1375                 1380             


Phe Tyr  Thr Leu Thr Val Val  Ala Asp Asp Gly Gly  Pro Lys Val 
    1385                 1390                 1395             


Asp Ser  Thr Val Gln Val Tyr  Ile Thr Val Leu Asp  Glu Asn Asp 
    1400                 1405                 1410             


Asn Ser  Pro Arg Phe Asp Phe  Thr Ser Asp Ser Ala  Val Ser Ile 
    1415                 1420                 1425             


Pro Glu  Asp Cys Pro Val Gly  Gln Arg Val Ala Thr  Val Lys Ala 
    1430                 1435                 1440             


Trp Asp  Pro Asp Ala Gly Ser  Asn Gly Gln Val Val  Phe Ser Leu 
    1445                 1450                 1455             


Ala Ser  Gly Asn Ile Ala Gly  Ala Phe Glu Ile Val  Thr Thr Asn 
    1460                 1465                 1470             


Asp Ser  Ile Gly Glu Val Phe  Val Ala Arg Pro Leu  Asp Arg Glu 
    1475                 1480                 1485             


Glu Leu  Asp His Tyr Ile Leu  Gln Val Val Ala Ser  Asp Arg Gly 
    1490                 1495                 1500             


Thr Pro  Pro Arg Lys Lys Asp  His Ile Leu Gln Val  Thr Ile Leu 
    1505                 1510                 1515             


Asp Ile  Asn Asp Asn Pro Pro  Val Ile Glu Ser Pro  Phe Gly Tyr 
    1520                 1525                 1530             


Asn Val  Ser Val Asn Glu Asn  Val Gly Gly Gly Thr  Ala Val Val 
    1535                 1540                 1545             


Gln Val  Arg Ala Thr Asp Arg  Asp Ile Gly Ile Asn  Ser Val Leu 
    1550                 1555                 1560             


Ser Tyr  Tyr Ile Thr Glu Gly  Asn Lys Asp Met Ala  Phe Arg Met 
    1565                 1570                 1575             


Asp Arg  Ile Ser Gly Glu Ile  Ala Thr Arg Pro Ala  Pro Pro Asp 
    1580                 1585                 1590             


Arg Glu  Arg Gln Ser Phe Tyr  His Leu Val Ala Thr  Val Glu Asp 
    1595                 1600                 1605             


Glu Gly  Thr Pro Thr Leu Ser  Ala Thr Thr His Val  Tyr Val Thr 
    1610                 1615                 1620             


Ile Val  Asp Glu Asn Asp Asn  Ala Pro Met Phe Gln  Gln Pro His 
    1625                 1630                 1635             


Tyr Glu  Val Leu Leu Asp Glu  Gly Pro Asp Thr Leu  Asn Thr Ser 
    1640                 1645                 1650             


Leu Ile  Thr Ile Gln Ala Leu  Asp Leu Asp Glu Gly  Pro Asn Gly 
    1655                 1660                 1665             


Thr Val  Thr Tyr Ala Ile Val  Ala Gly Asn Ile Val  Asn Thr Phe 
    1670                 1675                 1680             


Arg Ile  Asp Arg His Met Gly  Val Ile Thr Ala Ala  Lys Glu Leu 
    1685                 1690                 1695             


Asp Tyr  Glu Ile Ser His Gly  Arg Tyr Thr Leu Ile  Val Thr Ala 
    1700                 1705                 1710             


Thr Asp  Gln Cys Pro Ile Leu  Ser His Arg Leu Thr  Ser Thr Thr 
    1715                 1720                 1725             


Thr Val  Leu Val Asn Val Asn  Asp Ile Asn Asp Asn  Val Pro Thr 
    1730                 1735                 1740             


Phe Pro  Arg Asp Tyr Glu Gly  Pro Phe Glu Val Thr  Glu Gly Gln 
    1745                 1750                 1755             


Pro Gly  Pro Arg Val Trp Thr  Phe Leu Ala His Asp  Arg Asp Ser 
    1760                 1765                 1770             


Gly Pro  Asn Gly Gln Val Glu  Tyr Ser Ile Met Asp  Gly Asp Pro 
    1775                 1780                 1785             


Leu Gly  Glu Phe Val Ile Ser  Pro Val Glu Gly Val  Leu Arg Val 
    1790                 1795                 1800             


Arg Lys  Asp Val Glu Leu Asp  Arg Glu Thr Ile Ala  Phe Tyr Asn 
    1805                 1810                 1815             


Leu Thr  Ile Cys Ala Arg Asp  Arg Gly Met Pro Pro  Leu Ser Ser 
    1820                 1825                 1830             


Thr Met  Leu Val Gly Ile Arg  Val Leu Asp Ile Asn  Asp Asn Asp 
    1835                 1840                 1845             


Pro Val  Leu Leu Asn Leu Pro  Met Asn Ile Thr Ile  Ser Glu Asn 
    1850                 1855                 1860             


Ser Pro  Val Ser Ser Phe Val  Ala His Val Leu Ala  Ser Asp Ala 
    1865                 1870                 1875             


Asp Ser  Gly Cys Asn Ala Arg  Leu Thr Phe Asn Ile  Thr Ala Gly 
    1880                 1885                 1890             


Asn Arg  Glu Arg Ala Phe Phe  Ile Asn Ala Thr Thr  Gly Ile Val 
    1895                 1900                 1905             


Thr Val  Asn Arg Pro Leu Asp  Arg Glu Arg Ile Pro  Glu Tyr Lys 
    1910                 1915                 1920             


Leu Thr  Ile Ser Val Lys Asp  Asn Pro Glu Asn Pro  Arg Ile Ala 
    1925                 1930                 1935             


Arg Arg  Asp Tyr Asp Leu Leu  Leu Ile Phe Leu Ser  Asp Glu Asn 
    1940                 1945                 1950             


Asp Asn  His Pro Leu Phe Thr  Lys Ser Thr Tyr Gln  Ala Glu Val 
    1955                 1960                 1965             


Met Glu  Asn Ser Pro Ala Gly  Thr Pro Leu Thr Val  Leu Asn Gly 
    1970                 1975                 1980             


Pro Ile  Leu Ala Leu Asp Ala  Asp Gln Asp Ile Tyr  Ala Val Val 
    1985                 1990                 1995             


Thr Tyr  Gln Leu Leu Gly Ala  Gln Ser Gly Leu Phe  Asp Ile Asn 
    2000                 2005                 2010             


Ser Ser  Thr Gly Val Val Thr  Val Arg Ser Gly Val  Ile Ile Asp 
    2015                 2020                 2025             


Arg Glu  Ala Phe Ser Pro Pro  Ile Leu Glu Leu Leu  Leu Leu Ala 
    2030                 2035                 2040             


Glu Asp  Ile Gly Leu Leu Asn  Ser Thr Ala His Leu  Leu Ile Thr 
    2045                 2050                 2055             


Ile Leu  Asp Asp Asn Asp Asn  Arg Pro Thr Phe Ser  Pro Ala Thr 
    2060                 2065                 2070             


Leu Thr  Val His Leu Leu Glu  Asn Cys Pro Pro Gly  Phe Ser Val 
    2075                 2080                 2085             


Leu Gln  Val Thr Ala Thr Asp  Glu Asp Ser Gly Leu  Asn Gly Glu 
    2090                 2095                 2100             


Leu Val  Tyr Arg Ile Glu Ala  Gly Ala Gln Asp Arg  Phe Leu Ile 
    2105                 2110                 2115             


His Leu  Val Thr Gly Val Ile  Arg Val Gly Asn Ala  Thr Ile Asp 
    2120                 2125                 2130             


Arg Glu  Glu Gln Glu Ser Tyr  Arg Leu Thr Val Val  Ala Thr Asp 
    2135                 2140                 2145             


Arg Gly  Thr Val Pro Leu Ser  Gly Thr Ala Ile Val  Thr Ile Leu 
    2150                 2155                 2160             


Ile Asp  Asp Ile Asn Asp Ser  Arg Pro Glu Phe Leu  Asn Pro Ile 
    2165                 2170                 2175             


Gln Thr  Val Ser Val Leu Glu  Ser Ala Glu Pro Gly  Thr Val Ile 
    2180                 2185                 2190             


Ala Asn  Ile Thr Ala Ile Asp  His Asp Leu Asn Pro  Lys Leu Glu 
    2195                 2200                 2205             


Tyr His  Ile Val Gly Ile Val  Ala Lys Asp Asp Thr  Asp Arg Leu 
    2210                 2215                 2220             


Val Pro  Asn Gln Glu Asp Ala  Phe Ala Val Asn Ile  Asn Thr Gly 
    2225                 2230                 2235             


Ser Val  Met Val Lys Ser Pro  Met Asn Arg Glu Leu  Val Ala Thr 
    2240                 2245                 2250             


Tyr Glu  Val Thr Leu Ser Val  Ile Asp Asn Ala Ser  Asp Leu Pro 
    2255                 2260                 2265             


Glu Arg  Ser Val Ser Val Pro  Asn Ala Lys Leu Thr  Val Asn Val 
    2270                 2275                 2280             


Leu Asp  Val Asn Asp Asn Thr  Pro Gln Phe Lys Pro  Phe Gly Ile 
    2285                 2290                 2295             


Thr Tyr  Tyr Met Glu Arg Ile  Leu Glu Gly Ala Thr  Pro Gly Thr 
    2300                 2305                 2310             


Thr Leu  Ile Ala Val Ala Ala  Val Asp Pro Asp Lys  Gly Leu Asn 
    2315                 2320                 2325             


Gly Leu  Val Thr Tyr Thr Leu  Leu Asp Leu Val Pro  Pro Gly Tyr 
    2330                 2335                 2340             


Val Gln  Leu Glu Asp Ser Ser  Ala Gly Lys Val Ile  Ala Asn Arg 
    2345                 2350                 2355             


Thr Val  Asp Tyr Glu Glu Val  His Trp Leu Asn Phe  Thr Val Arg 
    2360                 2365                 2370             


Ala Ser  Asp Asn Gly Ser Pro  Pro Arg Ala Ala Glu  Ile Pro Val 
    2375                 2380                 2385             


Tyr Leu  Glu Ile Val Asp Ile  Asn Asp Asn Asn Pro  Ile Phe Asp 
    2390                 2395                 2400             


Gln Pro  Ser Tyr Gln Glu Ala  Val Phe Glu Asp Val  Pro Val Gly 
    2405                 2410                 2415             


Thr Ile  Ile Leu Thr Val Thr  Ala Thr Asp Ala Asp  Ser Gly Asn 
    2420                 2425                 2430             


Phe Ala  Leu Ile Glu Tyr Ser  Leu Gly Asp Gly Glu  Ser Lys Phe 
    2435                 2440                 2445             


Ala Ile  Asn Pro Thr Thr Gly  Asp Ile Tyr Val Leu  Ser Ser Leu 
    2450                 2455                 2460             


Asp Arg  Glu Lys Lys Asp His  Tyr Ile Leu Thr Ala  Leu Ala Lys 
    2465                 2470                 2475             


Asp Asn  Pro Gly Asp Val Ala  Ser Asn Arg Arg Glu  Asn Ser Val 
    2480                 2485                 2490             


Gln Val  Val Ile Gln Val Leu  Asp Val Asn Asp Cys  Arg Pro Gln 
    2495                 2500                 2505             


Phe Ser  Lys Pro Gln Phe Ser  Thr Ser Val Tyr Glu  Asn Glu Pro 
    2510                 2515                 2520             


Ala Gly  Thr Ser Val Ile Thr  Met Met Ala Thr Asp  Gln Asp Glu 
    2525                 2530                 2535             


Gly Pro  Asn Gly Glu Leu Thr  Tyr Ser Leu Glu Gly  Pro Gly Val 
    2540                 2545                 2550             


Glu Ala  Phe His Val Asp Met  Asp Ser Gly Leu Val  Thr Thr Gln 
    2555                 2560                 2565             


Arg Pro  Leu Gln Ser Tyr Glu  Lys Phe Ser Leu Thr  Val Val Ala 
    2570                 2575                 2580             


Thr Asp  Gly Gly Glu Pro Pro  Leu Trp Gly Thr Thr  Met Leu Leu 
    2585                 2590                 2595             


Val Glu  Val Ile Asp Val Asn  Asp Asn Arg Pro Val  Phe Val Arg 
    2600                 2605                 2610             


Pro Pro  Asn Gly Thr Ile Leu  His Ile Arg Glu Glu  Ile Pro Leu 
    2615                 2620                 2625             


Arg Ser  Asn Val Tyr Glu Val  Tyr Ala Thr Asp Lys  Asp Glu Gly 
    2630                 2635                 2640             


Leu Asn  Gly Ala Val Arg Tyr  Ser Phe Leu Lys Thr  Ala Gly Asn 
    2645                 2650                 2655             


Arg Asp  Trp Glu Phe Phe Ile  Ile Asp Pro Ile Ser  Gly Leu Ile 
    2660                 2665                 2670             


Gln Thr  Ala Gln Arg Leu Asp  Arg Glu Ser Gln Ala  Val Tyr Ser 
    2675                 2680                 2685             


Leu Ile  Leu Val Ala Ser Asp  Leu Gly Gln Pro Val  Pro Tyr Glu 
    2690                 2695                 2700             


Thr Met  Gln Pro Leu Gln Val  Ala Leu Glu Asp Ile  Asp Asp Asn 
    2705                 2710                 2715             


Glu Pro  Leu Phe Val Arg Pro  Pro Lys Gly Ser Pro  Gln Tyr Gln 
    2720                 2725                 2730             


Leu Leu  Thr Val Pro Glu His  Ser Pro Arg Gly Thr  Leu Val Gly 
    2735                 2740                 2745             


Asn Val  Thr Gly Ala Val Asp  Ala Asp Glu Gly Pro  Asn Ala Ile 
    2750                 2755                 2760             


Val Tyr  Tyr Phe Ile Ala Ala  Gly Asn Glu Glu Lys  Asn Phe His 
    2765                 2770                 2775             


Leu Gln  Pro Asp Gly Cys Leu  Leu Val Leu Arg Asp  Leu Asp Arg 
    2780                 2785                 2790             


Glu Arg  Glu Ala Ile Phe Ser  Phe Ile Val Lys Ala  Ser Ser Asn 
    2795                 2800                 2805             


Arg Ser  Trp Thr Pro Pro Arg  Gly Pro Ser Pro Thr  Leu Asp Leu 
    2810                 2815                 2820             


Val Ala  Asp Leu Thr Leu Gln  Glu Val Arg Val Val  Leu Glu Asp 
    2825                 2830                 2835             


Ile Asn  Asp Gln Pro Pro Arg  Phe Thr Lys Ala Glu  Tyr Thr Ala 
    2840                 2845                 2850             


Gly Val  Ala Thr Asp Ala Lys  Val Gly Ser Glu Leu  Ile Gln Val 
    2855                 2860                 2865             


Leu Ala  Leu Asp Ala Asp Ile  Gly Asn Asn Ser Leu  Val Phe Tyr 
    2870                 2875                 2880             


Ser Ile  Leu Ala Ile His Tyr  Phe Arg Ala Leu Ala  Asn Asp Ser 
    2885                 2890                 2895             


Glu Asp  Val Gly Gln Val Phe  Thr Met Gly Ser Met  Asp Gly Ile 
    2900                 2905                 2910             


Leu Arg  Thr Phe Asp Leu Phe  Met Ala Tyr Ser Pro  Gly Tyr Phe 
    2915                 2920                 2925             


Val Val  Asp Ile Val Ala Arg  Asp Leu Ala Gly His  Asn Asp Thr 
    2930                 2935                 2940             


Ala Ile  Ile Gly Ile Tyr Ile  Leu Arg Asp Asp Gln  Arg Val Lys 
    2945                 2950                 2955             


Ile Val  Ile Asn Glu Ile Pro  Asp Arg Val Arg Gly  Phe Glu Glu 
    2960                 2965                 2970             


Glu Phe  Ile His Leu Leu Ser  Asn Ile Thr Gly Ala  Ile Val Asn 
    2975                 2980                 2985             


Thr Asp  Asn Val Gln Phe His  Val Asp Lys Lys Gly  Arg Val Asn 
    2990                 2995                 3000             


Phe Ala  Gln Thr Glu Leu Leu  Ile His Val Val Asn  Arg Asp Thr 
    3005                 3010                 3015             


Asn Arg  Ile Leu Asp Val Asp  Arg Val Ile Gln Met  Ile Asp Glu 
    3020                 3025                 3030             


Asn Lys  Glu Gln Leu Arg Asn  Leu Phe Arg Asn Tyr  Asn Val Leu 
    3035                 3040                 3045             


Asp Val  Gln Pro Ala Ile Ser  Val Arg Leu Pro Asp  Asp Met Ser 
    3050                 3055                 3060             


Ala Leu  Gln Met Ala Ile Ile  Val Leu Ala Ile Leu  Leu Phe Leu 
    3065                 3070                 3075             


Ala Ala  Met Leu Phe Val Leu  Met Asn Trp Tyr Tyr  Arg Thr Val 
    3080                 3085                 3090             


His Lys  Arg Lys Leu Lys Ala  Ile Val Ala Gly Ser  Ala Gly Asn 
    3095                 3100                 3105             


Arg Gly  Phe Ile Asp Ile Met  Asp Met Pro Asn Thr  Asn Lys Tyr 
    3110                 3115                 3120             


Ser Phe  Asp Gly Ala Asn Pro  Val Trp Leu Asp Pro  Phe Cys Arg 
    3125                 3130                 3135             


Asn Leu  Glu Leu Ala Ala Gln  Ala Glu His Glu Asp  Asp Leu Pro 
    3140                 3145                 3150             


Glu Asn  Leu Ser Glu Ile Ala  Asp Leu Trp Asn Ser  Pro Thr Arg 
    3155                 3160                 3165             


Thr His  Gly Thr Phe Gly Arg  Glu Pro Ala Ala Val  Lys Pro Asp 
    3170                 3175                 3180             


Asp Asp  Arg Tyr Leu Arg Ala  Ala Ile Gln Glu Tyr  Asp Asn Ile 
    3185                 3190                 3195             


Ala Lys  Leu Gly Gln Ile Ile  Arg Glu Gly Pro Ile  Lys Gly Ser 
    3200                 3205                 3210             


Leu Leu  Lys Val Val Leu Glu  Asp Tyr Leu Arg Leu  Lys Lys Leu 
    3215                 3220                 3225             


Phe Ala  Gln Arg Met Val Gln  Lys Ala Ser Ser Cys  His Ser Ser 
    3230                 3235                 3240             


Ile Ser  Glu Leu Ile Gln Thr  Glu Leu Asp Glu Glu  Pro Gly Asp 
    3245                 3250                 3255             


His Ser  Pro Gly Gln Gly Ser  Leu Arg Phe Arg His  Lys Pro Pro 
    3260                 3265                 3270             


Val Glu  Leu Lys Gly Pro Asp  Gly Ile His Val Val  His Gly Ser 
    3275                 3280                 3285             


Thr Gly  Thr Leu Leu Ala Thr  Asp Leu Asn Ser Leu  Pro Glu Glu 
    3290                 3295                 3300             


Asp Gln  Lys Gly Leu Gly Arg  Ser Leu Glu Thr Leu  Thr Ala Ala 
    3305                 3310                 3315             


Glu Ala  Thr Ala Phe Glu Arg  Asn Ala Arg Thr Glu  Ser Ala Lys 
    3320                 3325                 3330             


Ser Thr  Pro Leu His Lys Leu  Arg Asp Val Ile Met  Glu Thr Pro 
    3335                 3340                 3345             


Leu Glu  Ile Thr Glu Leu 
    3350                 


<210>  2516
<211>  1381
<212>  PRT
<213>  Homo Sapiens

<400>  2516

Met Gly Arg His Val Ala Thr Ser Cys His Val Ala Trp Leu Leu Val 
1               5                   10                  15      


Leu Ile Ser Gly Cys Trp Gly Gln Val Asn Arg Leu Pro Phe Phe Thr 
            20                  25                  30          


Asn His Phe Phe Asp Thr Tyr Leu Leu Ile Ser Glu Asp Thr Pro Val 
        35                  40                  45              


Gly Ser Ser Val Thr Gln Leu Leu Ala Gln Asp Met Asp Asn Asp Pro 
    50                  55                  60                  


Leu Val Phe Gly Val Ser Gly Glu Glu Ala Ser Arg Phe Phe Ala Val 
65                  70                  75                  80  


Glu Pro Asp Thr Gly Val Val Trp Leu Arg Gln Pro Leu Asp Arg Glu 
                85                  90                  95      


Thr Lys Ser Glu Phe Thr Val Glu Phe Ser Val Ser Asp His Gln Gly 
            100                 105                 110         


Val Ile Thr Arg Lys Val Asn Ile Gln Val Gly Asp Val Asn Asp Asn 
        115                 120                 125             


Ala Pro Thr Phe His Asn Gln Pro Tyr Ser Val Arg Ile Pro Glu Asn 
    130                 135                 140                 


Thr Pro Val Gly Thr Pro Ile Phe Ile Val Asn Ala Thr Asp Pro Asp 
145                 150                 155                 160 


Leu Gly Ala Gly Gly Ser Val Leu Tyr Ser Phe Gln Pro Pro Ser Gln 
                165                 170                 175     


Phe Phe Ala Ile Asp Ser Ala Arg Gly Ile Val Thr Val Ile Arg Glu 
            180                 185                 190         


Leu Asp Tyr Glu Thr Thr Gln Ala Tyr Gln Leu Thr Val Asn Ala Thr 
        195                 200                 205             


Asp Gln Asp Lys Thr Arg Pro Leu Ser Thr Leu Ala Asn Leu Ala Ile 
    210                 215                 220                 


Ile Ile Thr Asp Val Gln Asp Met Asp Pro Ile Phe Ile Asn Leu Pro 
225                 230                 235                 240 


Tyr Ser Thr Asn Ile Tyr Glu His Ser Pro Pro Gly Thr Thr Val Arg 
                245                 250                 255     


Ile Ile Thr Ala Ile Asp Gln Asp Lys Gly Arg Pro Arg Gly Ile Gly 
            260                 265                 270         


Tyr Thr Ile Val Ser Gly Asn Thr Asn Ser Ile Phe Ala Leu Asp Tyr 
        275                 280                 285             


Ile Ser Gly Val Leu Thr Leu Asn Gly Leu Leu Asp Arg Glu Asn Pro 
    290                 295                 300                 


Leu Tyr Ser His Gly Phe Ile Leu Thr Val Lys Gly Thr Glu Leu Asn 
305                 310                 315                 320 


Asp Asp Arg Thr Pro Ser Asp Ala Thr Val Thr Thr Thr Phe Asn Ile 
                325                 330                 335     


Leu Val Ile Asp Ile Asn Asp Asn Ala Pro Glu Phe Asn Ser Ser Glu 
            340                 345                 350         


Tyr Ser Val Ala Ile Thr Glu Leu Ala Gln Val Gly Phe Ala Leu Pro 
        355                 360                 365             


Leu Phe Ile Gln Val Val Asp Lys Asp Glu Asn Leu Gly Leu Asn Ser 
    370                 375                 380                 


Met Phe Glu Val Tyr Leu Val Gly Asn Asn Ser His His Phe Ile Ile 
385                 390                 395                 400 


Ser Pro Thr Ser Val Gln Gly Lys Ala Asp Ile Arg Ile Arg Val Ala 
                405                 410                 415     


Ile Pro Leu Asp Tyr Glu Thr Val Asp Arg Tyr Asp Phe Asp Leu Phe 
            420                 425                 430         


Ala Asn Glu Ser Val Pro Asp His Val Gly Tyr Ala Lys Val Lys Ile 
        435                 440                 445             


Thr Leu Ile Asn Glu Asn Asp Asn Arg Pro Ile Phe Ser Gln Pro Leu 
    450                 455                 460                 


Tyr Asn Ile Ser Leu Tyr Glu Asn Val Thr Val Gly Thr Ser Val Leu 
465                 470                 475                 480 


Thr Val Leu Ala Thr Asp Asn Asp Ala Gly Thr Phe Gly Glu Val Ser 
                485                 490                 495     


Tyr Phe Phe Ser Asp Asp Pro Asp Arg Phe Ser Leu Asp Lys Asp Thr 
            500                 505                 510         


Gly Leu Ile Met Leu Ile Ala Arg Leu Asp Tyr Glu Leu Ile Gln Arg 
        515                 520                 525             


Phe Thr Leu Thr Ile Ile Ala Arg Asp Gly Gly Gly Glu Glu Thr Thr 
    530                 535                 540                 


Gly Arg Val Arg Ile Asn Val Leu Asp Val Asn Asp Asn Val Pro Thr 
545                 550                 555                 560 


Phe Gln Lys Asp Ala Tyr Val Gly Ala Leu Arg Glu Asn Glu Pro Ser 
                565                 570                 575     


Val Thr Gln Leu Val Arg Leu Arg Ala Thr Asp Glu Asp Ser Pro Pro 
            580                 585                 590         


Asn Asn Gln Ile Thr Tyr Ser Ile Val Ser Ala Ser Ala Phe Gly Ser 
        595                 600                 605             


Tyr Phe Asp Ile Ser Leu Tyr Glu Gly Tyr Gly Val Ile Ser Val Ser 
    610                 615                 620                 


Arg Pro Leu Asp Tyr Glu Gln Ile Ser Asn Gly Leu Ile Tyr Leu Thr 
625                 630                 635                 640 


Val Met Ala Met Asp Ala Gly Asn Pro Pro Leu Asn Ser Thr Val Pro 
                645                 650                 655     


Val Thr Ile Glu Val Phe Asp Glu Asn Asp Asn Pro Pro Thr Phe Ser 
            660                 665                 670         


Lys Pro Ala Tyr Phe Val Ser Val Val Glu Asn Ile Met Ala Gly Ala 
        675                 680                 685             


Thr Val Leu Phe Leu Asn Ala Thr Asp Leu Asp Arg Ser Arg Glu Tyr 
    690                 695                 700                 


Gly Gln Glu Ser Ile Ile Tyr Ser Leu Glu Gly Ser Thr Gln Phe Arg 
705                 710                 715                 720 


Ile Asn Ala Arg Ser Gly Glu Ile Thr Thr Thr Ser Leu Leu Asp Arg 
                725                 730                 735     


Glu Thr Lys Ser Glu Tyr Ile Leu Ile Val Arg Ala Val Asp Gly Gly 
            740                 745                 750         


Val Gly His Asn Gln Lys Thr Gly Ile Ala Thr Val Asn Ile Thr Leu 
        755                 760                 765             


Leu Asp Ile Asn Asp Asn His Pro Thr Trp Lys Asp Ala Pro Tyr Tyr 
    770                 775                 780                 


Ile Asn Leu Val Glu Met Thr Pro Pro Asp Ser Asp Val Thr Thr Val 
785                 790                 795                 800 


Val Ala Val Asp Pro Asp Leu Gly Glu Asn Gly Thr Leu Val Tyr Ser 
                805                 810                 815     


Ile Gln Pro Pro Asn Lys Phe Tyr Ser Leu Asn Ser Thr Thr Gly Lys 
            820                 825                 830         


Ile Arg Thr Thr His Ala Met Leu Asp Arg Glu Asn Pro Asp Pro His 
        835                 840                 845             


Glu Ala Glu Leu Met Arg Lys Ile Val Val Ser Val Thr Asp Cys Gly 
    850                 855                 860                 


Arg Pro Pro Leu Lys Ala Thr Ser Ser Ala Thr Val Phe Val Asn Leu 
865                 870                 875                 880 


Leu Asp Leu Asn Asp Asn Asp Pro Thr Phe Gln Asn Leu Pro Phe Val 
                885                 890                 895     


Ala Glu Val Leu Glu Gly Ile Pro Ala Gly Val Ser Ile Tyr Gln Val 
            900                 905                 910         


Val Ala Ile Asp Leu Asp Glu Gly Leu Asn Gly Leu Val Ser Tyr Arg 
        915                 920                 925             


Met Pro Val Gly Met Pro Arg Met Asp Phe Leu Ile Asn Ser Ser Ser 
    930                 935                 940                 


Gly Val Val Val Thr Thr Thr Glu Leu Asp Arg Glu Arg Ile Ala Glu 
945                 950                 955                 960 


Tyr Gln Leu Arg Val Val Ala Ser Asp Ala Gly Thr Pro Thr Lys Ser 
                965                 970                 975     


Ser Thr Ser Thr Leu Thr Ile His Val Leu Asp Val Asn Asp Glu Thr 
            980                 985                 990         


Pro Thr Phe Phe Pro Ala Val Tyr  Asn Val Ser Val Ser  Glu Asp Val 
        995                 1000                 1005             


Pro Arg  Glu Phe Arg Val Val  Trp Leu Asn Cys Thr  Asp Asn Asp 
    1010                 1015                 1020             


Val Gly  Leu Asn Ala Glu Leu  Ser Tyr Phe Ile Thr  Gly Gly Asn 
    1025                 1030                 1035             


Val Asp  Gly Lys Phe Ser Val  Gly Tyr Arg Asp Ala  Val Val Arg 
    1040                 1045                 1050             


Thr Val  Val Gly Leu Asp Arg  Glu Thr Thr Ala Ala  Tyr Met Leu 
    1055                 1060                 1065             


Ile Leu  Glu Ala Ile Asp Asn  Gly Pro Val Gly Lys  Arg His Thr 
    1070                 1075                 1080             


Gly Thr  Ala Thr Val Phe Val  Thr Val Leu Asp Val  Asn Asp Asn 
    1085                 1090                 1095             


Arg Pro  Ile Phe Leu Gln Ser  Ser Tyr Glu Ala Ser  Val Pro Glu 
    1100                 1105                 1110             


Asp Ile  Pro Glu Gly His Ser  Ile Leu Gln Leu Lys  Ala Thr Asp 
    1115                 1120                 1125             


Ala Asp  Glu Gly Glu Phe Gly  Arg Val Trp Tyr Arg  Ile Leu His 
    1130                 1135                 1140             


Gly Asn  His Gly Asn Asn Phe  Arg Ile His Val Ser  Asn Gly Leu 
    1145                 1150                 1155             


Leu Met  Arg Gly Pro Arg Pro  Leu Asp Arg Glu Arg  Asn Ser Ser 
    1160                 1165                 1170             


His Val  Leu Ile Val Glu Ala  Tyr Asn His Asp Leu  Gly Pro Met 
    1175                 1180                 1185             


Arg Ser  Ser Val Arg Val Ile  Val Tyr Val Glu Asp  Ile Asn Asp 
    1190                 1195                 1200             


Glu Ala  Pro Val Phe Thr Gln  Gln Gln Tyr Ser Arg  Leu Gly Leu 
    1205                 1210                 1215             


Arg Glu  Thr Ala Gly Ile Gly  Thr Ser Val Ile Val  Val Gln Ala 
    1220                 1225                 1230             


Thr Asp  Arg Asp Ser Gly Asp  Gly Gly Leu Val Asn  Tyr Arg Ile 
    1235                 1240                 1245             


Leu Ser  Gly Ala Glu Gly Lys  Phe Glu Ile Asp Glu  Ser Thr Gly 
    1250                 1255                 1260             


Leu Ile  Ile Thr Val Asn Tyr  Leu Asp Tyr Glu Thr  Lys Thr Ser 
    1265                 1270                 1275             


Tyr Met  Met Asn Val Ser Ala  Thr Asp Gln Ala Pro  Pro Phe Asn 
    1280                 1285                 1290             


Gln Gly  Phe Cys Ser Val Tyr  Ile Thr Leu Leu Asn  Glu Leu Asp 
    1295                 1300                 1305             


Glu Ala  Val Gln Phe Ser Asn  Ala Ser Tyr Glu Ala  Ala Ile Leu 
    1310                 1315                 1320             


Glu Asn  Leu Ala Leu Gly Thr  Glu Ile Val Arg Val  Gln Ala Tyr 
    1325                 1330                 1335             


Ser Ile  Asp Asn Leu Asn Gln  Ile Thr Tyr Arg Phe  Asn Ala Tyr 
    1340                 1345                 1350             


Thr Ser  Thr Gln Ala Lys Ala  Leu Phe Lys Ile Asp  Ala Ile Thr 
    1355                 1360                 1365             


Val Arg  Gly Trp Gly Gln Gly  Ala Pro Phe Leu Pro  Ile 
    1370                 1375                 1380     


<210>  2517
<211>  115
<212>  PRT
<213>  Homo Sapiens

<400>  2517

Met Ser Leu Arg Ala Gly Gly Lys Thr Arg Arg Trp Pro Gly Pro Glu 
1               5                   10                  15      


Gln Ala Ala Arg Gly Gly Arg Ser Gly Gly Glu Gln Ser Pro Arg Arg 
            20                  25                  30          


Gly Glu Ala Arg Arg Arg Cys Thr His Ala His Gly Ser Ser Val Thr 
        35                  40                  45              


Gln Leu Leu Ala Gln Asp Met Asp Asn Asp Pro Leu Val Phe Gly Val 
    50                  55                  60                  


Ser Gly Glu Glu Ala Ser Arg Phe Phe Ala Val Glu Pro Asp Thr Gly 
65                  70                  75                  80  


Val Val Trp Leu Arg Gln Pro Leu Asp Arg Glu Thr Lys Ser Glu Phe 
                85                  90                  95      


Thr Val Glu Phe Ser Val Ser Asp His Gln Gly Val Ile Thr Arg Lys 
            100                 105                 110         


Val Asn Ile 
        115 


<210>  2518
<211>  1114
<212>  PRT
<213>  Homo Sapiens

<400>  2518

Met Val Lys Ser Pro Met Asn Arg Glu Leu Val Ala Thr Tyr Glu Val 
1               5                   10                  15      


Thr Leu Ser Val Ile Asp Asn Ala Ser Asp Leu Pro Glu Arg Ser Val 
            20                  25                  30          


Ser Val Pro Asn Ala Lys Leu Thr Val Asn Val Leu Asp Val Asn Asp 
        35                  40                  45              


Asn Thr Pro Gln Phe Lys Pro Phe Gly Ile Thr Tyr Tyr Met Glu Arg 
    50                  55                  60                  


Ile Leu Glu Gly Ala Thr Pro Gly Thr Thr Leu Ile Ala Val Ala Ala 
65                  70                  75                  80  


Val Asp Pro Asp Lys Gly Leu Asn Gly Leu Val Thr Tyr Thr Leu Leu 
                85                  90                  95      


Asp Leu Val Pro Pro Gly Tyr Val Gln Leu Glu Asp Ser Ser Ala Gly 
            100                 105                 110         


Lys Val Ile Ala Asn Arg Thr Val Asp Tyr Glu Glu Val His Trp Leu 
        115                 120                 125             


Asn Phe Thr Val Arg Ala Ser Asp Asn Gly Ser Pro Pro Arg Ala Ala 
    130                 135                 140                 


Glu Ile Pro Val Tyr Leu Glu Ile Val Asp Ile Asn Asp Asn Asn Pro 
145                 150                 155                 160 


Ile Phe Asp Gln Pro Ser Tyr Gln Glu Ala Val Phe Glu Asp Val Pro 
                165                 170                 175     


Val Gly Thr Ile Ile Leu Thr Val Thr Ala Thr Asp Ala Asp Ser Gly 
            180                 185                 190         


Asn Phe Ala Leu Ile Glu Tyr Ser Leu Gly Asp Gly Glu Ser Lys Phe 
        195                 200                 205             


Ala Ile Asn Pro Thr Thr Gly Asp Ile Tyr Val Leu Ser Ser Leu Asp 
    210                 215                 220                 


Arg Glu Lys Lys Asp His Tyr Ile Leu Thr Ala Leu Ala Lys Asp Asn 
225                 230                 235                 240 


Pro Gly Asp Val Ala Ser Asn Arg Arg Glu Asn Ser Val Gln Val Val 
                245                 250                 255     


Ile Gln Val Leu Asp Val Asn Asp Cys Arg Pro Gln Phe Ser Lys Pro 
            260                 265                 270         


Gln Phe Ser Thr Ser Val Tyr Glu Asn Glu Pro Ala Gly Thr Ser Val 
        275                 280                 285             


Ile Thr Met Met Ala Thr Asp Gln Asp Glu Gly Pro Asn Gly Glu Leu 
    290                 295                 300                 


Thr Tyr Ser Leu Glu Gly Pro Gly Val Glu Ala Phe His Val Asp Met 
305                 310                 315                 320 


Asp Ser Gly Leu Val Thr Thr Gln Arg Pro Leu Gln Ser Tyr Glu Lys 
                325                 330                 335     


Phe Ser Leu Thr Val Val Ala Thr Asp Gly Gly Glu Pro Pro Leu Trp 
            340                 345                 350         


Gly Thr Thr Met Leu Leu Val Glu Val Ile Asp Val Asn Asp Asn Arg 
        355                 360                 365             


Pro Val Phe Val Arg Pro Pro Asn Gly Thr Ile Leu His Ile Arg Glu 
    370                 375                 380                 


Glu Ile Pro Leu Arg Ser Asn Val Tyr Glu Val Tyr Ala Thr Asp Lys 
385                 390                 395                 400 


Asp Glu Gly Leu Asn Gly Ala Val Arg Tyr Ser Phe Leu Lys Thr Ala 
                405                 410                 415     


Gly Asn Arg Asp Trp Glu Phe Phe Ile Ile Asp Pro Ile Ser Gly Leu 
            420                 425                 430         


Ile Gln Thr Ala Gln Arg Leu Asp Arg Glu Ser Gln Ala Val Tyr Ser 
        435                 440                 445             


Leu Ile Leu Val Ala Ser Asp Leu Gly Gln Pro Val Pro Tyr Glu Thr 
    450                 455                 460                 


Met Gln Pro Leu Gln Val Ala Leu Glu Asp Ile Asp Asp Asn Glu Pro 
465                 470                 475                 480 


Leu Phe Val Arg Pro Pro Lys Gly Ser Pro Gln Tyr Gln Leu Leu Thr 
                485                 490                 495     


Val Pro Glu His Ser Pro Arg Gly Thr Leu Val Gly Asn Val Thr Gly 
            500                 505                 510         


Ala Val Asp Ala Asp Glu Gly Pro Asn Ala Ile Val Tyr Tyr Phe Ile 
        515                 520                 525             


Ala Ala Gly Asn Glu Glu Lys Asn Phe His Leu Gln Pro Asp Gly Cys 
    530                 535                 540                 


Leu Leu Val Leu Arg Asp Leu Asp Arg Glu Arg Glu Ala Ile Phe Ser 
545                 550                 555                 560 


Phe Ile Val Lys Ala Ser Ser Asn Arg Ser Trp Thr Pro Pro Arg Gly 
                565                 570                 575     


Pro Ser Pro Thr Leu Asp Leu Val Ala Asp Leu Thr Leu Gln Glu Val 
            580                 585                 590         


Arg Val Val Leu Glu Asp Ile Asn Asp Gln Pro Pro Arg Phe Thr Lys 
        595                 600                 605             


Ala Glu Tyr Thr Ala Gly Val Ala Thr Asp Ala Lys Val Gly Ser Glu 
    610                 615                 620                 


Leu Ile Gln Val Leu Ala Leu Asp Ala Asp Ile Gly Asn Asn Ser Leu 
625                 630                 635                 640 


Val Phe Tyr Ser Ile Leu Ala Ile His Tyr Phe Arg Ala Leu Ala Asn 
                645                 650                 655     


Asp Ser Glu Asp Val Gly Gln Val Phe Thr Met Gly Ser Met Asp Gly 
            660                 665                 670         


Ile Leu Arg Thr Phe Asp Leu Phe Met Ala Tyr Ser Pro Gly Tyr Phe 
        675                 680                 685             


Val Val Asp Ile Val Ala Arg Asp Leu Ala Gly His Asn Asp Thr Ala 
    690                 695                 700                 


Ile Ile Gly Ile Tyr Ile Leu Arg Asp Asp Gln Arg Val Lys Ile Val 
705                 710                 715                 720 


Ile Asn Glu Ile Pro Asp Arg Val Arg Gly Phe Glu Glu Glu Phe Ile 
                725                 730                 735     


His Leu Leu Ser Asn Ile Thr Gly Ala Ile Val Asn Thr Asp Asn Val 
            740                 745                 750         


Gln Phe His Val Asp Lys Lys Gly Arg Val Asn Phe Ala Gln Thr Glu 
        755                 760                 765             


Leu Leu Ile His Val Val Asn Arg Asp Thr Asn Arg Ile Leu Asp Val 
    770                 775                 780                 


Asp Arg Val Ile Gln Met Ile Asp Glu Asn Lys Glu Gln Leu Arg Asn 
785                 790                 795                 800 


Leu Phe Arg Asn Tyr Asn Val Leu Asp Val Gln Pro Ala Ile Ser Val 
                805                 810                 815     


Arg Leu Pro Asp Asp Met Ser Ala Leu Gln Met Ala Ile Ile Val Leu 
            820                 825                 830         


Ala Ile Leu Leu Phe Leu Ala Ala Met Leu Phe Val Leu Met Asn Trp 
        835                 840                 845             


Tyr Tyr Arg Thr Val His Lys Arg Lys Leu Lys Ala Ile Val Ala Gly 
    850                 855                 860                 


Ser Ala Gly Asn Arg Gly Phe Ile Asp Ile Met Asp Met Pro Asn Thr 
865                 870                 875                 880 


Asn Lys Tyr Ser Phe Asp Gly Ala Asn Pro Val Trp Leu Asp Pro Phe 
                885                 890                 895     


Cys Arg Asn Leu Glu Leu Ala Ala Gln Ala Glu His Glu Asp Asp Leu 
            900                 905                 910         


Pro Glu Asn Leu Ser Glu Ile Ala Asp Leu Trp Asn Ser Pro Thr Arg 
        915                 920                 925             


Thr His Gly Thr Phe Gly Arg Glu Pro Ala Ala Val Lys Pro Asp Asp 
    930                 935                 940                 


Asp Arg Tyr Leu Arg Ala Ala Ile Gln Glu Tyr Asp Asn Ile Ala Lys 
945                 950                 955                 960 


Leu Gly Gln Ile Ile Arg Glu Gly Pro Ile Lys Gly Ser Leu Leu Lys 
                965                 970                 975     


Val Val Leu Glu Asp Tyr Leu Arg Leu Lys Lys Leu Phe Ala Gln Arg 
            980                 985                 990         


Met Val Gln Lys Ala Ser Ser Cys  His Ser Ser Ile Ser  Glu Leu Ile 
        995                 1000                 1005             


Gln Thr  Glu Leu Asp Glu Glu  Pro Gly Asp His Ser  Pro Gly Gln 
    1010                 1015                 1020             


Gly Ser  Leu Arg Phe Arg His  Lys Pro Pro Val Glu  Leu Lys Gly 
    1025                 1030                 1035             


Pro Asp  Gly Ile His Val Val  His Gly Ser Thr Gly  Thr Leu Leu 
    1040                 1045                 1050             


Ala Thr  Asp Leu Asn Ser Leu  Pro Glu Glu Asp Gln  Lys Gly Leu 
    1055                 1060                 1065             


Gly Arg  Ser Leu Glu Thr Leu  Thr Ala Ala Glu Ala  Thr Ala Phe 
    1070                 1075                 1080             


Glu Arg  Asn Ala Arg Thr Glu  Ser Ala Lys Ser Thr  Pro Leu His 
    1085                 1090                 1095             


Lys Leu  Arg Asp Val Ile Met  Glu Thr Pro Leu Glu  Ile Thr Glu 
    1100                 1105                 1110             


Leu 
    


<210>  2519
<211>  1079
<212>  PRT
<213>  Homo Sapiens

<400>  2519

Met Val Lys Ser Pro Met Asn Arg Glu Leu Val Ala Thr Tyr Glu Val 
1               5                   10                  15      


Thr Leu Ser Val Ile Asp Asn Ala Ser Asp Leu Pro Glu Arg Ser Val 
            20                  25                  30          


Ser Val Pro Asn Ala Lys Leu Thr Val Asn Val Leu Asp Val Asn Asp 
        35                  40                  45              


Asn Thr Pro Gln Phe Lys Pro Phe Gly Ile Thr Tyr Tyr Met Glu Arg 
    50                  55                  60                  


Ile Leu Glu Gly Ala Thr Pro Gly Thr Thr Leu Ile Ala Val Ala Ala 
65                  70                  75                  80  


Val Asp Pro Asp Lys Gly Leu Asn Gly Leu Val Thr Tyr Thr Leu Leu 
                85                  90                  95      


Asp Leu Val Pro Pro Gly Tyr Val Gln Leu Glu Asp Ser Ser Ala Gly 
            100                 105                 110         


Lys Val Ile Ala Asn Arg Thr Val Asp Tyr Glu Glu Val His Trp Leu 
        115                 120                 125             


Asn Phe Thr Val Arg Ala Ser Asp Asn Gly Ser Pro Pro Arg Ala Ala 
    130                 135                 140                 


Glu Ile Pro Val Tyr Leu Glu Ile Val Asp Ile Asn Asp Asn Asn Pro 
145                 150                 155                 160 


Ile Phe Asp Gln Pro Ser Tyr Gln Glu Ala Val Phe Glu Asp Val Pro 
                165                 170                 175     


Val Gly Thr Ile Ile Leu Thr Val Thr Ala Thr Asp Ala Asp Ser Gly 
            180                 185                 190         


Asn Phe Ala Leu Ile Glu Tyr Ser Leu Gly Asp Gly Glu Ser Lys Phe 
        195                 200                 205             


Ala Ile Asn Pro Thr Thr Gly Asp Ile Tyr Val Leu Ser Ser Leu Asp 
    210                 215                 220                 


Arg Glu Lys Lys Asp His Tyr Ile Leu Thr Ala Leu Ala Lys Asp Asn 
225                 230                 235                 240 


Pro Gly Asp Val Ala Ser Asn Arg Arg Glu Asn Ser Val Gln Val Val 
                245                 250                 255     


Ile Gln Val Leu Asp Val Asn Asp Cys Arg Pro Gln Phe Ser Lys Pro 
            260                 265                 270         


Gln Phe Ser Thr Ser Val Tyr Glu Asn Glu Pro Ala Gly Thr Ser Val 
        275                 280                 285             


Ile Thr Met Met Ala Thr Asp Gln Asp Glu Gly Pro Asn Gly Glu Leu 
    290                 295                 300                 


Thr Tyr Ser Leu Glu Gly Pro Gly Val Glu Ala Phe His Val Asp Met 
305                 310                 315                 320 


Asp Ser Gly Leu Val Thr Thr Gln Arg Pro Leu Gln Ser Tyr Glu Lys 
                325                 330                 335     


Phe Ser Leu Thr Val Val Ala Thr Asp Gly Gly Glu Pro Pro Leu Trp 
            340                 345                 350         


Gly Thr Thr Met Leu Leu Val Glu Val Ile Asp Val Asn Asp Asn Arg 
        355                 360                 365             


Pro Val Phe Val Arg Pro Pro Asn Gly Thr Ile Leu His Ile Arg Glu 
    370                 375                 380                 


Glu Ile Pro Leu Arg Ser Asn Val Tyr Glu Val Tyr Ala Thr Asp Lys 
385                 390                 395                 400 


Asp Glu Gly Leu Asn Gly Ala Val Arg Tyr Ser Phe Leu Lys Thr Ala 
                405                 410                 415     


Gly Asn Arg Asp Trp Glu Phe Phe Ile Ile Asp Pro Ile Ser Gly Leu 
            420                 425                 430         


Ile Gln Thr Ala Gln Arg Leu Asp Arg Glu Ser Gln Ala Val Tyr Ser 
        435                 440                 445             


Leu Ile Leu Val Ala Ser Asp Leu Gly Gln Pro Val Pro Tyr Glu Thr 
    450                 455                 460                 


Met Gln Pro Leu Gln Val Ala Leu Glu Asp Ile Asp Asp Asn Glu Pro 
465                 470                 475                 480 


Leu Phe Val Arg Pro Pro Lys Gly Ser Pro Gln Tyr Gln Leu Leu Thr 
                485                 490                 495     


Val Pro Glu His Ser Pro Arg Gly Thr Leu Val Gly Asn Val Thr Gly 
            500                 505                 510         


Ala Val Asp Ala Asp Glu Gly Pro Asn Ala Ile Val Tyr Tyr Phe Ile 
        515                 520                 525             


Ala Ala Gly Asn Glu Glu Lys Asn Phe His Leu Gln Pro Asp Gly Cys 
    530                 535                 540                 


Leu Leu Val Leu Arg Asp Leu Asp Arg Glu Arg Glu Ala Ile Phe Ser 
545                 550                 555                 560 


Phe Ile Val Lys Ala Ser Ser Asn Arg Ser Trp Thr Pro Pro Arg Gly 
                565                 570                 575     


Pro Ser Pro Thr Leu Asp Leu Val Ala Asp Leu Thr Leu Gln Glu Val 
            580                 585                 590         


Arg Val Val Leu Glu Asp Ile Asn Asp Gln Pro Pro Arg Phe Thr Lys 
        595                 600                 605             


Ala Glu Tyr Thr Ala Gly Val Ala Thr Asp Ala Lys Val Gly Ser Glu 
    610                 615                 620                 


Leu Ile Gln Val Leu Ala Leu Asp Ala Asp Ile Gly Asn Asn Ser Leu 
625                 630                 635                 640 


Val Phe Tyr Ser Ile Leu Ala Ile His Tyr Phe Arg Ala Leu Ala Asn 
                645                 650                 655     


Asp Ser Glu Asp Val Gly Gln Val Phe Thr Met Gly Ser Met Asp Gly 
            660                 665                 670         


Ile Leu Arg Thr Phe Asp Leu Phe Met Ala Tyr Ser Pro Gly Tyr Phe 
        675                 680                 685             


Val Val Asp Ile Val Ala Arg Asp Leu Ala Gly His Asn Asp Thr Ala 
    690                 695                 700                 


Ile Ile Gly Ile Tyr Ile Leu Arg Asp Asp Gln Arg Val Lys Ile Val 
705                 710                 715                 720 


Ile Asn Glu Ile Pro Asp Arg Val Arg Gly Phe Glu Glu Glu Phe Ile 
                725                 730                 735     


His Leu Leu Ser Asn Ile Thr Gly Ala Ile Val Asn Thr Asp Asn Val 
            740                 745                 750         


Gln Phe His Val Asp Lys Lys Gly Arg Val Asn Phe Ala Gln Thr Glu 
        755                 760                 765             


Leu Leu Ile His Val Val Asn Arg Asp Thr Asn Arg Ile Leu Asp Val 
    770                 775                 780                 


Asp Arg Val Ile Gln Met Ile Asp Glu Asn Lys Glu Gln Leu Arg Asn 
785                 790                 795                 800 


Leu Phe Arg Asn Tyr Asn Val Leu Asp Val Gln Pro Ala Ile Ser Val 
                805                 810                 815     


Arg Leu Pro Asp Asp Met Ser Ala Leu Gln Met Ala Ile Ile Val Leu 
            820                 825                 830         


Ala Ile Leu Leu Phe Leu Ala Ala Met Leu Phe Val Leu Met Asn Trp 
        835                 840                 845             


Tyr Tyr Arg Thr Val His Lys Arg Lys Leu Lys Ala Ile Val Ala Gly 
    850                 855                 860                 


Ser Ala Gly Asn Arg Gly Phe Ile Asp Ile Met Asp Met Pro Asn Thr 
865                 870                 875                 880 


Asn Lys Tyr Ser Phe Asp Gly Ala Asn Pro Val Trp Leu Asp Pro Phe 
                885                 890                 895     


Cys Arg Asn Leu Glu Leu Ala Ala Gln Ala Glu His Glu Asp Asp Leu 
            900                 905                 910         


Pro Glu Asn Leu Ser Glu Ile Ala Asp Leu Trp Asn Ser Pro Thr Arg 
        915                 920                 925             


Thr His Gly Thr Phe Gly Arg Glu Pro Ala Ala Val Lys Pro Asp Asp 
    930                 935                 940                 


Asp Arg Tyr Leu Arg Ala Ala Ile Gln Glu Tyr Asp Asn Ile Ala Lys 
945                 950                 955                 960 


Leu Gly Gln Ile Ile Arg Glu Gly Pro Ile Lys Leu Ile Gln Thr Glu 
                965                 970                 975     


Leu Asp Glu Glu Pro Gly Asp His Ser Pro Gly Gln Gly Ser Leu Arg 
            980                 985                 990         


Phe Arg His Lys Pro Pro Val Glu  Leu Lys Gly Pro Asp  Gly Ile His 
        995                 1000                 1005             


Val Val  His Gly Ser Thr Gly  Thr Leu Leu Ala Thr  Asp Leu Asn 
    1010                 1015                 1020             


Ser Leu  Pro Glu Glu Asp Gln  Lys Gly Leu Gly Arg  Ser Leu Glu 
    1025                 1030                 1035             


Thr Leu  Thr Ala Ala Glu Ala  Thr Ala Phe Glu Arg  Asn Ala Arg 
    1040                 1045                 1050             


Thr Glu  Ser Ala Lys Ser Thr  Pro Leu His Lys Leu  Arg Asp Val 
    1055                 1060                 1065             


Ile Met  Glu Thr Pro Leu Glu  Ile Thr Glu Leu 
    1070                 1075                 


<210>  2520
<211>  6
<212>  PRT
<213>  Homo Sapiens

<400>  2520

Pro Cys Cys Thr Leu Asn 
1               5       


<210>  2521
<211>  29
<212>  PRT
<213>  Homo Sapiens

<400>  2521

Thr Gly Lys Gly His Gly Ala Asp Thr Cys Thr Ser Trp Lys Ala Gln 
1               5                   10                  15      


Arg Asn Asp Arg Arg Ile Asn Met Ala Val Thr Lys His 
            20                  25                  


<210>  2522
<211>  396
<212>  PRT
<213>  Homo Sapiens

<400>  2522

Val Ile Thr Arg Lys Val Asn Ile Gln Val Gly Asp Val Asn Asp Asn 
1               5                   10                  15      


Ala Pro Thr Phe His Asn Gln Pro Tyr Ser Val Arg Ile Pro Glu Asn 
            20                  25                  30          


Thr Pro Val Gly Thr Pro Ile Phe Ile Val Asn Ala Thr Asp Pro Asp 
        35                  40                  45              


Leu Gly Ala Gly Gly Ser Val Leu Tyr Ser Phe Gln Pro Pro Ser Gln 
    50                  55                  60                  


Phe Phe Ala Ile Asp Ser Ala Arg Gly Ile Val Thr Val Ile Arg Glu 
65                  70                  75                  80  


Leu Asp Tyr Glu Thr Thr Gln Ala Tyr Gln Leu Thr Val Asn Ala Thr 
                85                  90                  95      


Asp Gln Asp Lys Thr Arg Pro Leu Ser Thr Leu Ala Asn Leu Ala Ile 
            100                 105                 110         


Ile Ile Thr Asp Val Gln Asp Met Asp Pro Ile Phe Ile Asn Leu Pro 
        115                 120                 125             


Tyr Ser Thr Asn Ile Tyr Glu His Ser Pro Pro Gly Thr Thr Val Arg 
    130                 135                 140                 


Ile Ile Thr Ala Ile Asp Gln Asp Lys Gly Arg Pro Arg Gly Ile Gly 
145                 150                 155                 160 


Tyr Thr Ile Val Ser Gly Asn Thr Asn Ser Ile Phe Ala Leu Asp Tyr 
                165                 170                 175     


Ile Ser Gly Val Leu Thr Leu Asn Gly Leu Leu Asp Arg Glu Asn Pro 
            180                 185                 190         


Leu Tyr Ser His Gly Phe Ile Leu Thr Val Lys Gly Thr Glu Leu Asn 
        195                 200                 205             


Asp Asp Arg Thr Pro Ser Asp Ala Thr Val Thr Thr Thr Phe Asn Ile 
    210                 215                 220                 


Leu Val Ile Asp Ile Asn Asp Asn Ala Pro Glu Phe Asn Ser Ser Glu 
225                 230                 235                 240 


Tyr Ser Val Ala Ile Thr Glu Leu Ala Gln Val Gly Phe Ala Leu Pro 
                245                 250                 255     


Leu Phe Ile Gln Val Val Asp Lys Asp Glu Asn Leu Gly Leu Asn Ser 
            260                 265                 270         


Met Phe Glu Val Tyr Leu Val Gly Asn Asn Ser His His Phe Ile Ile 
        275                 280                 285             


Ser Pro Thr Ser Val Gln Gly Lys Ala Asp Ile Arg Ile Arg Val Ala 
    290                 295                 300                 


Ile Pro Leu Asp Tyr Glu Thr Val Asp Arg Tyr Asp Phe Asp Leu Phe 
305                 310                 315                 320 


Ala Asn Glu Ser Val Pro Asp His Val Gly Tyr Ala Lys Val Lys Ile 
                325                 330                 335     


Thr Leu Ile Asn Glu Asn Asp Asn Arg Pro Ile Phe Ser Gln Pro Leu 
            340                 345                 350         


Tyr Asn Ile Ser Leu Tyr Glu Asn Val Thr Val Gly Thr Ser Val Leu 
        355                 360                 365             


Thr Val Leu Trp Glu Lys Phe Phe Cys Ser Asn Ser Ser Arg Phe Ser 
    370                 375                 380                 


Ser Ala Gln Leu Val Val Ser Ser Trp Asn Gln Leu 
385                 390                 395     


<210>  2523
<211>  1035
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2523

Xaa Asp Lys Thr Arg Pro Leu Ser Thr Leu Ala Asn Leu Ala Ile Ile 
1               5                   10                  15      


Ile Thr Asp Val Gln Asp Met Asp Pro Ile Phe Ile Asn Leu Pro Tyr 
            20                  25                  30          


Ser Thr Asn Ile Tyr Glu His Ser Pro Pro Gly Thr Thr Val Arg Ile 
        35                  40                  45              


Ile Thr Ala Ile Asp Gln Asp Lys Gly Arg Pro Arg Gly Ile Gly Tyr 
    50                  55                  60                  


Thr Ile Val Ser Gly Asn Thr Asn Ser Ile Phe Ala Leu Asp Tyr Ile 
65                  70                  75                  80  


Ser Gly Val Leu Thr Leu Asn Gly Leu Leu Asp Arg Glu Asn Pro Leu 
                85                  90                  95      


Tyr Ser His Gly Phe Ile Leu Thr Val Lys Gly Thr Glu Leu Asn Asp 
            100                 105                 110         


Asp Arg Thr Pro Ser Asp Ala Thr Val Thr Thr Thr Phe Asn Ile Leu 
        115                 120                 125             


Val Ile Asp Ile Asn Asp Asn Ala Pro Glu Phe Asn Ser Ser Glu Tyr 
    130                 135                 140                 


Ser Val Ala Ile Thr Glu Leu Ala Gln Val Gly Phe Ala Leu Pro Leu 
145                 150                 155                 160 


Phe Ile Gln Val Val Asp Lys Asp Glu Glu Asn Gly Gly Trp Leu Gln 
                165                 170                 175     


Gly Arg Pro Glu Gly Val Gly Glu Gly Leu His Val Gln Asn Leu Gly 
            180                 185                 190         


Leu Asn Ser Met Phe Glu Val Tyr Leu Val Gly Asn Asn Ser His His 
        195                 200                 205             


Phe Ile Ile Ser Pro Thr Ser Val Gln Gly Lys Ala Asp Ile Arg Ile 
    210                 215                 220                 


Arg Val Ala Ile Pro Leu Asp Tyr Glu Thr Val Asp Arg Tyr Asp Phe 
225                 230                 235                 240 


Asp Leu Phe Ala Asn Glu Ser Val Pro Asp His Val Gly Tyr Ala Lys 
                245                 250                 255     


Val Lys Ile Thr Leu Ile Asn Glu Asn Asp Asn Arg Pro Ile Phe Ser 
            260                 265                 270         


Gln Pro Leu Tyr Asn Ile Ser Leu Tyr Glu Asn Val Thr Val Gly Thr 
        275                 280                 285             


Ser Val Leu Thr Val Leu Ala Thr Asp Asn Asp Ala Gly Thr Phe Gly 
    290                 295                 300                 


Glu Val Ser Tyr Phe Phe Ser Asp Asp Pro Asp Arg Phe Ser Leu Asp 
305                 310                 315                 320 


Lys Asp Thr Gly Leu Ile Met Leu Ile Ala Arg Leu Asp Tyr Glu Leu 
                325                 330                 335     


Ile Gln Arg Phe Thr Leu Thr Ile Ile Ala Arg Asp Gly Gly Gly Glu 
            340                 345                 350         


Glu Thr Thr Gly Arg Val Arg Ile Asn Val Leu Asp Val Asn Asp Asn 
        355                 360                 365             


Val Pro Thr Phe Gln Lys Asp Ala Tyr Val Gly Ala Leu Arg Glu Asn 
    370                 375                 380                 


Glu Pro Ser Val Thr Gln Leu Val Arg Leu Arg Ala Thr Asp Glu Asp 
385                 390                 395                 400 


Ser Pro Pro Asn Asn Gln Ile Thr Tyr Ser Ile Val Ser Ala Ser Ala 
                405                 410                 415     


Phe Gly Ser Tyr Phe Asp Ile Ser Leu Tyr Glu Gly Tyr Gly Val Ile 
            420                 425                 430         


Ser Val Ser Arg Pro Leu Asp Tyr Glu Gln Ile Ser Asn Gly Leu Ile 
        435                 440                 445             


Tyr Leu Thr Val Met Ala Met Asp Ala Gly Asn Pro Pro Leu Asn Ser 
    450                 455                 460                 


Thr Val Pro Val Thr Ile Glu Val Phe Asp Glu Asn Asp Asn Pro Pro 
465                 470                 475                 480 


Thr Phe Ser Lys Pro Ala Tyr Phe Val Ser Val Val Glu Asn Ile Met 
                485                 490                 495     


Ala Gly Ala Thr Val Leu Phe Leu Asn Ala Thr Asp Leu Asp Arg Ser 
            500                 505                 510         


Arg Glu Tyr Gly Gln Glu Ser Ile Ile Tyr Ser Leu Glu Gly Ser Thr 
        515                 520                 525             


Gln Phe Arg Ile Asn Ala Arg Ser Gly Glu Ile Thr Thr Thr Ser Leu 
    530                 535                 540                 


Leu Asp Arg Glu Thr Lys Ser Glu Tyr Ile Leu Ile Val Arg Ala Val 
545                 550                 555                 560 


Asp Gly Gly Val Gly His Asn Gln Lys Thr Gly Ile Ala Thr Val Asn 
                565                 570                 575     


Ile Thr Leu Leu Asp Ile Asn Asp Asn His Pro Thr Trp Lys Asp Ala 
            580                 585                 590         


Pro Tyr Tyr Ile Asn Leu Val Glu Met Thr Pro Pro Asp Ser Asp Val 
        595                 600                 605             


Thr Thr Val Val Ala Val Asp Pro Asp Leu Gly Glu Asn Gly Thr Leu 
    610                 615                 620                 


Val Tyr Ser Ile Gln Pro Pro Asn Lys Phe Tyr Ser Leu Asn Ser Thr 
625                 630                 635                 640 


Thr Gly Lys Ile Arg Thr Thr His Ala Met Leu Asp Arg Glu Asn Pro 
                645                 650                 655     


Asp Pro His Glu Ala Glu Leu Met Arg Lys Ile Val Val Ser Val Thr 
            660                 665                 670         


Asp Cys Gly Arg Pro Pro Leu Lys Ala Thr Ser Ser Ala Thr Val Phe 
        675                 680                 685             


Val Asn Leu Leu Asp Leu Asn Asp Asn Asp Pro Thr Phe Gln Asn Leu 
    690                 695                 700                 


Pro Phe Val Ala Glu Val Leu Glu Gly Ile Pro Ala Gly Val Ser Ile 
705                 710                 715                 720 


Tyr Gln Val Val Ala Ile Asp Leu Asp Glu Gly Leu Asn Gly Leu Val 
                725                 730                 735     


Ser Tyr Arg Met Pro Val Gly Met Pro Arg Met Asp Phe Leu Ile Asn 
            740                 745                 750         


Ser Ser Ser Gly Val Val Val Thr Thr Thr Glu Leu Asp Arg Glu Arg 
        755                 760                 765             


Ile Ala Glu Tyr Gln Leu Arg Val Val Ala Ser Asp Ala Gly Thr Pro 
    770                 775                 780                 


Thr Lys Ser Ser Thr Ser Thr Leu Thr Ile His Val Leu Asp Val Asn 
785                 790                 795                 800 


Asp Glu Thr Pro Thr Phe Phe Pro Ala Val Tyr Asn Val Ser Val Ser 
                805                 810                 815     


Glu Asp Val Pro Arg Glu Phe Arg Val Val Trp Leu Asn Cys Thr Asp 
            820                 825                 830         


Asn Asp Val Gly Leu Asn Ala Glu Leu Ser Tyr Phe Ile Thr Gly Gly 
        835                 840                 845             


Asn Val Asp Gly Lys Phe Ser Val Gly Tyr Arg Asp Ala Val Val Arg 
    850                 855                 860                 


Thr Val Val Gly Leu Asp Arg Glu Thr Thr Ala Ala Tyr Met Leu Ile 
865                 870                 875                 880 


Leu Glu Ala Ile Asp Asn Gly Pro Val Gly Lys Arg His Thr Gly Thr 
                885                 890                 895     


Ala Thr Val Phe Val Thr Val Leu Asp Val Asn Asp Asn Arg Pro Ile 
            900                 905                 910         


Phe Leu Gln Ser Ser Tyr Glu Ala Ser Val Pro Glu Asp Ile Pro Glu 
        915                 920                 925             


Gly His Ser Ile Leu Gln His Pro Pro Trp Pro Leu Lys Gly Ala Ser 
    930                 935                 940                 


Ser Ile Ile Phe Asn Pro Phe Leu Ile Asp Pro Asn Val Gly Ala Leu 
945                 950                 955                 960 


Lys Arg Gly His Gln Asp Gly Cys Gln Asp His Ala Trp Arg Ala Leu 
                965                 970                 975     


Phe Ala Pro Pro Pro Ser Trp His Pro Gly Ile Cys Ser Thr Arg Arg 
            980                 985                 990         


Glu Ala Ala Ala Pro Thr Gly His  Gln Ala Asp Ala Gly  Ser Thr Arg 
        995                 1000                 1005             


Glu Thr  Gln Gly Arg Glu Pro  Arg Gly Phe Ala Pro  Ala Leu Gly 
    1010                 1015                 1020             


Gln His  Arg Cys Gln Asp Ser  Val Leu Ala Pro Val  
    1025                 1030                 1035 


<210>  2524
<211>  165
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2524

Xaa Asp Asn Ala Pro Glu Phe Asn Ser Ser Glu Tyr Ser Val Ala Ile 
1               5                   10                  15      


Thr Glu Leu Ala Gln Val Gly Phe Ala Leu Pro Leu Phe Ile Gln Val 
            20                  25                  30          


Val Asp Lys Asp Glu Gly Leu Asn Ser Met Phe Glu Val Tyr Leu Val 
        35                  40                  45              


Gly Asn Asn Ser His His Phe Ile Ile Ser Pro Thr Ser Val Gln Gly 
    50                  55                  60                  


Lys Ala Asp Ile Arg Ile Arg Val Ala Ile Pro Leu Asp Tyr Glu Thr 
65                  70                  75                  80  


Val Asp Arg Tyr Asp Phe Asp Leu Phe Ala Asn Glu Ser Val Pro Asp 
                85                  90                  95      


His Val Gly Tyr Ala Lys Val Lys Ile Thr Leu Ile Asn Glu Asn Asp 
            100                 105                 110         


Asn Arg Pro Ile Phe Ser Gln Pro Leu Tyr Asn Ile Ser Leu Tyr Glu 
        115                 120                 125             


Asn Val Thr Val Gly Thr Ser Val Leu Thr Val Leu Trp Glu Lys Phe 
    130                 135                 140                 


Phe Cys Ser Asn Ser Ser Arg Phe Ser Ser Ala Gln Leu Val Val Ser 
145                 150                 155                 160 


Ser Trp Asn Gln Leu 
                165 


<210>  2525
<211>  223
<212>  PRT
<213>  Homo Sapiens

<400>  2525

Met Pro Ser Arg Thr Gly Thr Ser Thr Leu Thr Val Ala Val Cys Lys 
1               5                   10                  15      


Cys Asn Glu Gln Gly Glu Phe Thr Phe Cys Glu Asp Met Ala Ala Gln 
            20                  25                  30          


Val Gly Val Ser Ile Gln Ala Val Val Ala Ile Leu Leu Cys Ile Leu 
        35                  40                  45              


Thr Ile Thr Val Ile Thr Leu Leu Ile Phe Leu Arg Arg Arg Leu Arg 
    50                  55                  60                  


Lys Gln Ala Arg Ala His Gly Lys Ser Val Pro Glu Ile His Glu Gln 
65                  70                  75                  80  


Leu Val Thr Tyr Asp Glu Glu Gly Gly Gly Glu Met Asp Thr Thr Ser 
                85                  90                  95      


Tyr Asp Val Ser Val Leu Asn Ser Val Arg Arg Gly Gly Ala Lys Pro 
            100                 105                 110         


Pro Arg Pro Ala Leu Asp Ala Arg Pro Ser Leu Tyr Ala Gln Val Gln 
        115                 120                 125             


Lys Pro Pro Arg His Ala Pro Gly Ala His Gly Gly Pro Gly Glu Met 
    130                 135                 140                 


Ala Ala Met Ile Glu Val Lys Lys Asp Glu Ala Asp His Asp Gly Asp 
145                 150                 155                 160 


Gly Pro Pro Tyr Asp Thr Leu His Ile Tyr Gly Tyr Glu Gly Ser Glu 
                165                 170                 175     


Ser Ile Ala Glu Ser Leu Ser Ser Leu Gly Thr Asp Ser Ser Asp Ser 
            180                 185                 190         


Asp Val Asp Tyr Asp Phe Leu Asn Asp Trp Gly Pro Arg Phe Lys Met 
        195                 200                 205             


Leu Ala Glu Leu Tyr Gly Ser Asp Pro Arg Glu Glu Leu Leu Tyr 
    210                 215                 220             


<210>  2526
<211>  17
<212>  PRT
<213>  Homo Sapiens

<400>  2526

Met Gln Arg Leu Met Met Leu Leu Ala Thr Ser Gly Ala Cys Leu Gly 
1               5                   10                  15      


Leu 
    


<210>  2527
<211>  76
<212>  PRT
<213>  Homo Sapiens

<400>  2527

Met Gln Arg Leu Met Met Leu Leu Ala Thr Ser Gly Ala Cys Leu Gly 
1               5                   10                  15      


Leu Leu Ala Val Ala Ala Val Ala Ala Ala Gly Ala Asn Pro Ala Gln 
            20                  25                  30          


Arg Asp Thr His Ser Leu Leu Pro Thr His Arg Arg Gln Lys Arg Asp 
        35                  40                  45              


Trp Ile Trp Asn Gln Met His Ile Asp Glu Glu Lys Asn Thr Ser Leu 
    50                  55                  60                  


Pro His His Val Gly Lys Ile Lys Ser Ser Val Ser 
65                  70                  75      


<210>  2528
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  2528

Met Gln Arg Leu Met Met Leu Leu Ala Thr Ser Gly Ala Cys Leu Gly 
1               5                   10                  15      


Leu Leu Ala Val Ala Ala Val Ala Ala Ala Gly Ala Asn Pro Ala Gln 
            20                  25                  30          


Arg Asp Thr His Ser Leu Leu Pro Thr His Arg Arg Gln Lys Arg Asp 
        35                  40                  45              


Trp Ile Trp Asn Gln Met His Ile Asp Glu Glu Lys Asn Thr Ser Leu 
    50                  55                  60                  


Pro His His Val Gly Lys Ile Lys Ser Ser Val Ser Arg Lys Asn Ala 
65                  70                  75                  80  


Lys Tyr Leu Leu Lys Gly Glu Tyr Val Gly Lys Val Phe Arg Val Asp 
                85                  90                  95      


Ala Glu Thr Gly Asp Val Phe Ala Ile Glu Arg Leu Asp Arg Glu Asn 
            100                 105                 110         


Ile Ser Glu Tyr His Leu Thr Ala Val Ile Val Asp Lys Asp Thr Gly 
        115                 120                 125             


Glu Asn Leu 
    130     


<210>  2529
<211>  784
<212>  PRT
<213>  Homo Sapiens

<400>  2529

Met Gln Arg Leu Met Met Leu Leu Ala Thr Ser Gly Ala Cys Leu Gly 
1               5                   10                  15      


Leu Leu Ala Val Ala Ala Val Ala Ala Ala Gly Ala Asn Pro Ala Gln 
            20                  25                  30          


Arg Asp Thr His Ser Leu Leu Pro Thr His Arg Arg Gln Lys Arg Asp 
        35                  40                  45              


Trp Ile Trp Asn Gln Met His Ile Asp Glu Glu Lys Asn Thr Ser Leu 
    50                  55                  60                  


Pro His His Val Gly Lys Ile Lys Ser Ser Val Ser Arg Lys Asn Ala 
65                  70                  75                  80  


Lys Tyr Leu Leu Lys Gly Glu Tyr Val Gly Lys Val Phe Arg Val Asp 
                85                  90                  95      


Ala Glu Thr Gly Asp Val Phe Ala Ile Glu Arg Leu Asp Arg Glu Asn 
            100                 105                 110         


Ile Ser Glu Tyr His Leu Thr Ala Val Ile Val Asp Lys Asp Thr Gly 
        115                 120                 125             


Glu Asn Leu Glu Thr Pro Ser Ser Phe Thr Ile Lys Val His Asp Val 
    130                 135                 140                 


Asn Asp Asn Trp Pro Val Phe Thr His Arg Leu Phe Asn Ala Ser Val 
145                 150                 155                 160 


Pro Glu Ser Ser Ala Val Gly Thr Ser Val Ile Ser Val Thr Ala Val 
                165                 170                 175     


Asp Ala Asp Asp Pro Thr Val Gly Asp His Ala Ser Val Met Tyr Gln 
            180                 185                 190         


Ile Leu Lys Gly Lys Glu Tyr Phe Ala Ile Asp Asn Ser Gly Arg Ile 
        195                 200                 205             


Ile Thr Ile Thr Lys Ser Leu Asp Arg Glu Lys Gln Ala Arg Tyr Glu 
    210                 215                 220                 


Ile Val Val Glu Ala Arg Asp Ala Gln Gly Leu Arg Gly Asp Ser Gly 
225                 230                 235                 240 


Thr Ala Thr Val Leu Val Thr Leu Gln Asp Ile Asn Asp Asn Phe Pro 
                245                 250                 255     


Phe Phe Thr Gln Thr Lys Tyr Thr Phe Val Val Pro Glu Asp Thr Arg 
            260                 265                 270         


Val Gly Thr Ser Val Gly Ser Leu Phe Val Glu Asp Pro Asp Glu Pro 
        275                 280                 285             


Gln Asn Arg Met Thr Lys Tyr Ser Ile Leu Arg Gly Asp Tyr Gln Asp 
    290                 295                 300                 


Ala Phe Thr Ile Glu Thr Asn Pro Ala His Asn Glu Gly Ile Ile Lys 
305                 310                 315                 320 


Pro Met Lys Pro Leu Asp Tyr Glu Tyr Ile Gln Gln Tyr Ser Phe Ile 
                325                 330                 335     


Val Glu Ala Thr Asp Pro Thr Ile Asp Leu Arg Tyr Met Ser Pro Pro 
            340                 345                 350         


Ala Gly Asn Arg Ala Gln Val Ile Ile Asn Ile Thr Asp Val Asp Glu 
        355                 360                 365             


Pro Pro Ile Phe Gln Gln Pro Phe Tyr His Phe Gln Leu Lys Glu Asn 
    370                 375                 380                 


Gln Lys Lys Pro Leu Ile Gly Thr Val Leu Ala Met Asp Pro Asp Ala 
385                 390                 395                 400 


Ala Arg His Ser Ile Gly Tyr Ser Ile Arg Arg Thr Ser Asp Lys Gly 
                405                 410                 415     


Gln Phe Phe Arg Val Thr Lys Lys Gly Asp Ile Tyr Asn Glu Lys Glu 
            420                 425                 430         


Leu Asp Arg Glu Val Tyr Pro Trp Tyr Asn Leu Thr Val Glu Ala Lys 
        435                 440                 445             


Glu Leu Asp Ser Thr Gly Thr Pro Thr Gly Lys Glu Ser Ile Val Gln 
    450                 455                 460                 


Val His Ile Glu Val Leu Asp Glu Asn Asp Asn Ala Pro Glu Phe Ala 
465                 470                 475                 480 


Lys Pro Tyr Gln Pro Lys Val Cys Glu Asn Ala Val His Gly Gln Leu 
                485                 490                 495     


Val Leu Gln Ile Ser Ala Ile Asp Lys Asp Ile Thr Pro Arg Asn Val 
            500                 505                 510         


Lys Phe Lys Phe Ile Leu Asn Thr Glu Asn Asn Phe Thr Leu Thr Asp 
        515                 520                 525             


Asn His Asp Asn Thr Ala Asn Ile Thr Val Lys Tyr Gly Gln Phe Asp 
    530                 535                 540                 


Arg Glu His Thr Lys Val His Phe Leu Pro Val Val Ile Ser Asp Asn 
545                 550                 555                 560 


Gly Met Pro Ser Arg Thr Gly Thr Ser Thr Leu Thr Val Ala Val Cys 
                565                 570                 575     


Lys Cys Asn Glu Gln Gly Glu Phe Thr Phe Cys Glu Asp Met Ala Ala 
            580                 585                 590         


Gln Val Gly Val Ser Ile Gln Ala Val Val Ala Ile Leu Leu Cys Ile 
        595                 600                 605             


Leu Thr Ile Thr Val Ile Thr Leu Leu Ile Phe Leu Arg Arg Arg Leu 
    610                 615                 620                 


Arg Lys Gln Ala Arg Ala His Gly Lys Ser Val Pro Glu Ile His Glu 
625                 630                 635                 640 


Gln Leu Val Thr Tyr Asp Glu Glu Gly Gly Gly Glu Met Asp Thr Thr 
                645                 650                 655     


Ser Tyr Asp Val Ser Val Leu Asn Ser Val Arg Arg Gly Gly Ala Lys 
            660                 665                 670         


Pro Pro Arg Pro Ala Leu Asp Ala Arg Pro Ser Leu Tyr Ala Gln Val 
        675                 680                 685             


Gln Lys Pro Pro Arg His Ala Pro Gly Ala His Gly Gly Pro Gly Glu 
    690                 695                 700                 


Met Ala Ala Met Ile Glu Val Lys Lys Asp Glu Ala Asp His Asp Gly 
705                 710                 715                 720 


Asp Gly Pro Pro Tyr Asp Thr Leu His Ile Tyr Gly Tyr Glu Gly Ser 
                725                 730                 735     


Glu Ser Ile Ala Glu Ser Leu Ser Ser Leu Gly Thr Asp Ser Ser Asp 
            740                 745                 750         


Ser Asp Val Asp Tyr Asp Phe Leu Asn Asp Trp Gly Pro Arg Phe Lys 
        755                 760                 765             


Met Leu Ala Glu Leu Tyr Gly Ser Asp Pro Arg Glu Glu Leu Leu Tyr 
    770                 775                 780                 


<210>  2530
<211>  406
<212>  PRT
<213>  Homo Sapiens

<400>  2530

Met Gln Arg Leu Met Met Leu Leu Ala Thr Ser Gly Ala Cys Leu Gly 
1               5                   10                  15      


Leu Leu Ala Val Ala Ala Val Ala Ala Ala Gly Ala Asn Pro Ala Gln 
            20                  25                  30          


Arg Asp Thr His Ser Leu Leu Pro Thr His Arg Arg Gln Lys Arg Asp 
        35                  40                  45              


Trp Ile Trp Asn Gln Met His Ile Asp Glu Glu Lys Asn Thr Ser Leu 
    50                  55                  60                  


Pro His His Val Gly Lys Ile Lys Ser Ser Val Ser Arg Lys Asn Ala 
65                  70                  75                  80  


Lys Tyr Leu Leu Lys Gly Glu Tyr Val Gly Lys Val Phe Arg Val Asp 
                85                  90                  95      


Ala Glu Thr Gly Asp Val Phe Ala Ile Glu Arg Leu Asp Arg Glu Asn 
            100                 105                 110         


Ile Ser Glu Tyr His Leu Thr Ala Val Ile Val Asp Lys Asp Thr Gly 
        115                 120                 125             


Glu Asn Leu Glu Thr Pro Ser Ser Phe Thr Ile Lys Val His Asp Val 
    130                 135                 140                 


Asn Asp Asn Trp Pro Val Phe Thr His Arg Leu Phe Asn Ala Ser Val 
145                 150                 155                 160 


Pro Glu Ser Ser Ala Val Gly Thr Ser Val Ile Ser Val Thr Ala Val 
                165                 170                 175     


Asp Ala Asp Asp Pro Thr Val Gly Asp His Ala Ser Val Met Tyr Gln 
            180                 185                 190         


Ile Leu Lys Gly Lys Glu Tyr Phe Ala Ile Asp Asn Ser Gly Arg Ile 
        195                 200                 205             


Ile Thr Ile Thr Lys Ser Leu Asp Arg Glu Lys Gln Ala Arg Tyr Glu 
    210                 215                 220                 


Ile Val Val Glu Ala Arg Asp Ala Gln Gly Leu Arg Gly Asp Ser Gly 
225                 230                 235                 240 


Thr Ala Thr Val Leu Val Thr Leu Gln Asp Ile Asn Asp Asn Phe Pro 
                245                 250                 255     


Phe Phe Thr Gln Thr Lys Tyr Thr Phe Val Val Pro Glu Asp Thr Arg 
            260                 265                 270         


Val Gly Thr Ser Val Gly Ser Leu Phe Val Glu Asp Pro Asp Glu Pro 
        275                 280                 285             


Gln Asn Arg Met Thr Lys Tyr Ser Ile Leu Arg Gly Asp Tyr Gln Asp 
    290                 295                 300                 


Ala Phe Thr Ile Glu Thr Asn Pro Ala His Asn Glu Gly Ile Ile Lys 
305                 310                 315                 320 


Pro Met Lys Pro Leu Asp Tyr Glu Tyr Ile Gln Gln Tyr Ser Phe Ile 
                325                 330                 335     


Val Glu Ala Thr Asp Pro Thr Ile Asp Leu Arg Tyr Met Ser Pro Pro 
            340                 345                 350         


Ala Gly Asn Arg Ala Gln Val Ile Ile Asn Ile Thr Asp Val Asp Glu 
        355                 360                 365             


Pro Pro Ile Phe Gln Gln Pro Phe Tyr His Phe Gln Leu Lys Glu Asn 
    370                 375                 380                 


Gln Lys Lys Pro Leu Ile Gly Thr Val Leu Ala Met Asp Pro Asp Ala 
385                 390                 395                 400 


Ala Arg His Ser Ile Gly 
                405     


<210>  2531
<211>  669
<212>  PRT
<213>  Homo Sapiens

<400>  2531

Met Gln Arg Leu Met Met Leu Leu Ala Thr Ser Gly Ala Cys Leu Gly 
1               5                   10                  15      


Leu Leu Ala Val Ala Ala Val Ala Ala Ala Gly Ala Asn Pro Ala Gln 
            20                  25                  30          


Arg Asp Thr His Ser Leu Leu Pro Thr His Arg Arg Gln Lys Arg Asp 
        35                  40                  45              


Trp Ile Trp Asn Gln Met His Ile Asp Glu Glu Lys Asn Thr Ser Leu 
    50                  55                  60                  


Pro His His Val Gly Lys Ile Lys Ser Ser Val Ser Arg Lys Asn Ala 
65                  70                  75                  80  


Lys Tyr Leu Leu Lys Gly Glu Tyr Val Gly Lys Val Phe Arg Val Asp 
                85                  90                  95      


Ala Glu Thr Gly Asp Val Phe Ala Ile Glu Arg Leu Asp Arg Glu Asn 
            100                 105                 110         


Ile Ser Glu Tyr His Leu Thr Ala Val Ile Val Asp Lys Asp Thr Gly 
        115                 120                 125             


Glu Asn Leu Glu Thr Pro Ser Ser Phe Thr Ile Lys Val His Asp Val 
    130                 135                 140                 


Asn Asp Asn Trp Pro Val Phe Thr His Arg Leu Phe Asn Ala Ser Val 
145                 150                 155                 160 


Pro Glu Ser Ser Ala Val Gly Thr Ser Val Ile Ser Val Thr Ala Val 
                165                 170                 175     


Asp Ala Asp Asp Pro Thr Val Gly Asp His Ala Ser Val Met Tyr Gln 
            180                 185                 190         


Ile Leu Lys Gly Lys Glu Tyr Phe Ala Ile Asp Asn Ser Gly Arg Ile 
        195                 200                 205             


Ile Thr Ile Thr Lys Ser Leu Asp Arg Glu Lys Gln Ala Arg Tyr Glu 
    210                 215                 220                 


Ile Val Val Glu Ala Arg Asp Ala Gln Gly Leu Arg Gly Asp Ser Gly 
225                 230                 235                 240 


Thr Ala Thr Val Leu Val Thr Leu Gln Asp Ile Asn Asp Asn Phe Pro 
                245                 250                 255     


Phe Phe Thr Gln Thr Lys Tyr Thr Phe Val Val Pro Glu Asp Thr Arg 
            260                 265                 270         


Val Gly Thr Ser Val Gly Ser Leu Phe Val Glu Asp Pro Asp Glu Pro 
        275                 280                 285             


Gln Asn Arg Met Thr Lys Tyr Ser Ile Leu Arg Gly Asp Tyr Gln Asp 
    290                 295                 300                 


Ala Phe Thr Ile Glu Thr Asn Pro Ala His Asn Glu Gly Ile Ile Lys 
305                 310                 315                 320 


Pro Met Lys Pro Leu Asp Tyr Glu Tyr Ile Gln Gln Tyr Ser Phe Ile 
                325                 330                 335     


Val Glu Ala Thr Asp Pro Thr Ile Asp Leu Arg Tyr Met Ser Pro Pro 
            340                 345                 350         


Ala Gly Asn Arg Ala Gln Val Ile Ile Asn Ile Thr Asp Val Asp Glu 
        355                 360                 365             


Pro Pro Ile Phe Gln Gln Pro Phe Tyr His Phe Gln Leu Val Leu Gln 
    370                 375                 380                 


Ile Ser Ala Ile Asp Lys Asp Ile Thr Pro Arg Asn Val Lys Phe Lys 
385                 390                 395                 400 


Phe Ile Leu Asn Thr Glu Asn Asn Phe Thr Leu Thr Asp Asn His Asp 
                405                 410                 415     


Asn Thr Ala Asn Ile Thr Val Lys Tyr Gly Gln Phe Asp Arg Glu His 
            420                 425                 430         


Thr Lys Val His Phe Leu Pro Val Val Ile Ser Asp Asn Gly Met Pro 
        435                 440                 445             


Ser Arg Thr Gly Thr Ser Thr Leu Thr Val Ala Val Cys Lys Cys Asn 
    450                 455                 460                 


Glu Gln Gly Glu Phe Thr Phe Cys Glu Asp Met Ala Ala Gln Val Gly 
465                 470                 475                 480 


Val Ser Ile Gln Ala Val Val Ala Ile Leu Leu Cys Ile Leu Thr Ile 
                485                 490                 495     


Thr Val Ile Thr Leu Leu Ile Phe Leu Arg Arg Arg Leu Arg Lys Gln 
            500                 505                 510         


Ala Arg Ala His Gly Lys Ser Val Pro Glu Ile His Glu Gln Leu Val 
        515                 520                 525             


Thr Tyr Asp Glu Glu Gly Gly Gly Glu Met Asp Thr Thr Ser Tyr Asp 
    530                 535                 540                 


Val Ser Val Leu Asn Ser Val Arg Arg Gly Gly Ala Lys Pro Pro Arg 
545                 550                 555                 560 


Pro Ala Leu Asp Ala Arg Pro Ser Leu Tyr Ala Gln Val Gln Lys Pro 
                565                 570                 575     


Pro Arg His Ala Pro Gly Ala His Gly Gly Pro Gly Glu Met Ala Ala 
            580                 585                 590         


Met Ile Glu Val Lys Lys Asp Glu Ala Asp His Asp Gly Asp Gly Pro 
        595                 600                 605             


Pro Tyr Asp Thr Leu His Ile Tyr Gly Tyr Glu Gly Ser Glu Ser Ile 
    610                 615                 620                 


Ala Glu Ser Leu Ser Ser Leu Gly Thr Asp Ser Ser Asp Ser Asp Val 
625                 630                 635                 640 


Asp Tyr Asp Phe Leu Asn Asp Trp Gly Pro Arg Phe Lys Met Leu Ala 
                645                 650                 655     


Glu Leu Tyr Gly Ser Asp Pro Arg Glu Glu Leu Leu Tyr 
            660                 665                 


<210>  2532
<211>  110
<212>  PRT
<213>  Homo Sapiens

<400>  2532

Met Gln Arg Leu Met Met Leu Leu Ala Thr Ser Gly Ala Cys Leu Gly 
1               5                   10                  15      


Leu Leu Ala Val Ala Ala Val Ala Ala Ala Gly Ala Asn Pro Ala Gln 
            20                  25                  30          


Arg Asp Thr His Ser Leu Leu Pro Thr His Arg Arg Gln Lys Arg Asp 
        35                  40                  45              


Trp Ile Trp Asn Gln Met His Ile Asp Glu Glu Lys Asn Thr Ser Leu 
    50                  55                  60                  


Pro His His Val Gly Lys Ile Lys Ser Ser Val Ser Arg Lys Asn Ala 
65                  70                  75                  80  


Lys Tyr Leu Leu Lys Gly Glu Tyr Val Gly Lys Val Phe Arg Val Asp 
                85                  90                  95      


Ala Glu Thr Gly Asp Val Thr Gln Met Ser Pro Arg Thr Gly 
            100                 105                 110 


<210>  2533
<211>  745
<212>  PRT
<213>  Homo Sapiens

<400>  2533

Met Arg Arg Cys Arg Trp Ala Ala Leu Ala Leu Gly Leu Leu Arg Leu 
1               5                   10                  15      


Cys Leu Ala Gln Ala Asn Phe Ala Pro His Phe Phe Asp Asn Gly Val 
            20                  25                  30          


Gly Ser Thr Asn Gly Asn Met Ala Leu Phe Ser Leu Pro Glu Asp Thr 
        35                  40                  45              


Pro Val Gly Ser His Val Tyr Thr Leu Asn Gly Thr Asp Pro Glu Gly 
    50                  55                  60                  


Asp Pro Ile Ser Tyr His Ile Ser Phe Asp Pro Ser Thr Arg Ser Val 
65                  70                  75                  80  


Phe Ser Val Asp Pro Thr Phe Gly Asn Ile Thr Leu Val Glu Glu Leu 
                85                  90                  95      


Asp Arg Glu Arg Glu Asp Glu Ile Glu Ala Ile Ile Ser Ile Ser Asp 
            100                 105                 110         


Gly Leu Asn Leu Val Ala Glu Lys Val Val Ile Leu Val Thr Asp Ala 
        115                 120                 125             


Asn Asp Glu Ala Pro Arg Phe Ile Gln Glu Pro Tyr Val Ala Leu Val 
    130                 135                 140                 


Pro Glu Asp Ile Pro Ala Gly Ser Ile Ile Phe Lys Val His Ala Val 
145                 150                 155                 160 


Asp Arg Asp Thr Gly Ser Gly Gly Ser Val Thr Tyr Phe Leu Gln Asn 
                165                 170                 175     


Leu His Ser Pro Phe Ala Val Asp Arg His Ser Gly Val Leu Arg Leu 
            180                 185                 190         


Gln Ala Gly Ala Thr Leu Asp Tyr Glu Arg Ser Arg Thr His Tyr Ile 
        195                 200                 205             


Thr Val Val Ala Lys Asp Gly Gly Gly Arg Leu His Gly Ala Asp Val 
    210                 215                 220                 


Val Phe Ser Ala Thr Thr Thr Val Thr Val Asn Val Glu Asp Val Gln 
225                 230                 235                 240 


Asp Met Ala Pro Val Phe Val Gly Thr Pro Tyr Tyr Gly Tyr Val Tyr 
                245                 250                 255     


Glu Asp Thr Leu Pro Gly Ser Glu Val Leu Lys Val Val Ala Met Asp 
            260                 265                 270         


Gly Asp Arg Gly Lys Pro Asn Arg Ile Leu Tyr Ser Leu Val Asn Gly 
        275                 280                 285             


Asn Asp Gly Ala Phe Glu Ile Asn Glu Thr Ser Gly Ala Ile Ser Ile 
    290                 295                 300                 


Thr Gln Ser Pro Ala Gln Leu Gln Arg Glu Val Tyr Glu Leu His Val 
305                 310                 315                 320 


Gln Val Thr Glu Met Ser Pro Ala Gly Ser Pro Ala Ala Gln Ala Thr 
                325                 330                 335     


Val Pro Val Thr Ile Arg Ile Val Asp Leu Asn Asn His Pro Pro Thr 
            340                 345                 350         


Phe Tyr Gly Glu Ser Gly Pro Gln Asn Arg Phe Glu Leu Ser Met Asn 
        355                 360                 365             


Glu His Pro Pro Gln Gly Glu Ile Leu Arg Gly Leu Lys Ile Thr Val 
    370                 375                 380                 


Asn Asp Ser Asp Gln Gly Ala Asn Ala Lys Phe Asn Leu Gln Leu Val 
385                 390                 395                 400 


Gly Pro Arg Gly Ile Phe Arg Val Val Pro Gln Thr Val Leu Asn Glu 
                405                 410                 415     


Ala Gln Val Thr Ile Ile Val Glu Asn Ser Ala Ala Ile Asp Phe Glu 
            420                 425                 430         


Lys Ser Lys Val Leu Thr Phe Lys Leu Leu Ala Val Glu Val Asn Thr 
        435                 440                 445             


Pro Glu Lys Phe Ser Ser Thr Ala Asp Val Val Ile Gln Leu Leu Asp 
    450                 455                 460                 


Thr Asn Asp Asn Val Pro Lys Phe Asp Ser Leu Tyr Tyr Val Ala Arg 
465                 470                 475                 480 


Ile Pro Glu Asn Ala Pro Gly Gly Ser Ser Val Val Ala Val Thr Ala 
                485                 490                 495     


Val Asp Pro Asp Thr Gly Pro Trp Gly Glu Val Lys Tyr Ser Thr Tyr 
            500                 505                 510         


Gly Thr Gly Ala Asp Leu Phe Leu Ile His Pro Ser Thr Gly Leu Ile 
        515                 520                 525             


Tyr Thr Gln Pro Trp Ala Ser Leu Asp Ala Glu Ala Thr Ala Arg Tyr 
    530                 535                 540                 


Asn Phe Tyr Val Lys Ala Glu Asp Met Glu Gly Lys Tyr Ser Val Ala 
545                 550                 555                 560 


Glu Val Phe Ile Thr Leu Leu Asp Val Asn Asp His Pro Pro Gln Phe 
                565                 570                 575     


Gly Lys Ser Val Gln Lys Lys Thr Met Val Leu Gly Thr Pro Val Lys 
            580                 585                 590         


Ile Glu Ala Ile Asp Glu Asp Ala Glu Glu Pro Asn Asn Leu Val Asp 
        595                 600                 605             


Tyr Ser Ile Thr His Ala Glu Pro Ala Asn Val Phe Asp Ile Asn Ser 
    610                 615                 620                 


His Thr Gly Glu Ile Trp Leu Lys Asn Ser Ile Arg Ser Leu Asp Ala 
625                 630                 635                 640 


Leu His Asn Ile Thr Pro Gly Arg Asp Cys Leu Trp Ser Leu Glu Val 
                645                 650                 655     


Gln Ala Lys Asp Arg Gly Ser Pro Ser Phe Ser Thr Thr Ala Leu Leu 
            660                 665                 670         


Lys Ile Asp Ile Thr Asp Ala Glu Val Arg Arg Leu Arg Tyr Met Lys 
        675                 680                 685             


Asn Ser Asn Phe Pro Gly Thr Thr Lys Ser Val Arg Lys Pro Lys Phe 
    690                 695                 700                 


Lys Pro Lys Lys Pro His Ser Ser Gln Gly Leu Phe Leu His Pro His 
705                 710                 715                 720 


Cys Glu Ile Ala Leu Phe Asn Leu Ser Asn Val Asn Leu Tyr Ser Arg 
                725                 730                 735     


Val Phe Gln Gly Ala Ala Gln Ala Ser 
            740                 745 


<210>  2534
<211>  859
<212>  PRT
<213>  Homo Sapiens

<400>  2534

Met Arg Arg Cys Arg Trp Ala Ala Leu Ala Leu Gly Leu Leu Arg Leu 
1               5                   10                  15      


Cys Leu Ala Gln Ala Asn Phe Ala Pro His Phe Phe Asp Asn Gly Val 
            20                  25                  30          


Gly Ser Thr Asn Gly Asn Met Ala Leu Phe Ser Leu Pro Glu Asp Thr 
        35                  40                  45              


Pro Val Gly Ser His Val Tyr Thr Leu Asn Gly Thr Asp Pro Glu Gly 
    50                  55                  60                  


Asp Pro Ile Ser Tyr His Ile Ser Phe Asp Pro Ser Thr Arg Ser Val 
65                  70                  75                  80  


Phe Ser Val Asp Pro Thr Phe Gly Asn Ile Thr Leu Val Glu Glu Leu 
                85                  90                  95      


Asp Arg Glu Arg Glu Asp Glu Ile Glu Ala Ile Ile Ser Ile Ser Asp 
            100                 105                 110         


Gly Leu Asn Leu Val Ala Glu Lys Val Val Ile Leu Val Thr Asp Ala 
        115                 120                 125             


Asn Asp Glu Ala Pro Arg Phe Ile Gln Glu Pro Tyr Val Ala Leu Val 
    130                 135                 140                 


Pro Glu Asp Ile Pro Ala Gly Ser Ile Ile Phe Lys Val His Ala Val 
145                 150                 155                 160 


Asp Arg Asp Thr Gly Ser Gly Gly Ser Val Thr Tyr Phe Leu Gln Asn 
                165                 170                 175     


Leu His Ser Pro Phe Ala Val Asp Arg His Ser Gly Val Leu Arg Leu 
            180                 185                 190         


Gln Ala Gly Ala Thr Leu Asp Tyr Glu Arg Ser Arg Thr His Tyr Ile 
        195                 200                 205             


Thr Val Val Ala Lys Asp Gly Gly Gly Arg Leu His Gly Ala Asp Val 
    210                 215                 220                 


Val Phe Ser Ala Thr Thr Thr Val Thr Val Asn Val Glu Asp Val Gln 
225                 230                 235                 240 


Asp Met Ala Pro Val Phe Val Gly Thr Pro Tyr Tyr Gly Tyr Val Tyr 
                245                 250                 255     


Glu Asp Thr Leu Pro Gly Ser Glu Val Leu Lys Val Val Ala Met Asp 
            260                 265                 270         


Gly Asp Arg Gly Lys Pro Asn Arg Ile Leu Tyr Ser Leu Val Asn Gly 
        275                 280                 285             


Asn Asp Gly Ala Phe Glu Ile Asn Glu Thr Ser Gly Ala Ile Ser Ile 
    290                 295                 300                 


Thr Gln Ser Pro Ala Gln Leu Gln Arg Glu Val Tyr Glu Leu His Val 
305                 310                 315                 320 


Gln Val Thr Glu Met Ser Pro Ala Gly Ser Pro Ala Ala Gln Ala Thr 
                325                 330                 335     


Val Pro Val Thr Ile Arg Ile Val Asp Leu Asn Asn His Pro Pro Thr 
            340                 345                 350         


Phe Tyr Gly Glu Ser Gly Pro Gln Asn Arg Phe Glu Leu Ser Met Asn 
        355                 360                 365             


Glu His Pro Pro Gln Gly Glu Ile Leu Arg Gly Leu Lys Ile Thr Val 
    370                 375                 380                 


Asn Asp Ser Asp Gln Gly Ala Asn Ala Lys Phe Asn Leu Gln Leu Val 
385                 390                 395                 400 


Gly Pro Arg Gly Ile Phe Arg Val Val Pro Gln Thr Val Leu Asn Glu 
                405                 410                 415     


Ala Gln Val Thr Ile Ile Val Glu Asn Ser Ala Ala Ile Asp Phe Glu 
            420                 425                 430         


Lys Ser Lys Val Leu Thr Phe Lys Leu Leu Ala Val Glu Val Asn Thr 
        435                 440                 445             


Pro Glu Lys Phe Ser Ser Thr Ala Asp Val Val Ile Gln Leu Leu Asp 
    450                 455                 460                 


Thr Asn Asp Asn Val Pro Lys Phe Asp Ser Leu Tyr Tyr Val Ala Arg 
465                 470                 475                 480 


Ile Pro Glu Asn Ala Pro Gly Gly Ser Ser Val Val Ala Val Thr Ala 
                485                 490                 495     


Val Asp Pro Asp Thr Gly Pro Trp Gly Glu Val Lys Tyr Ser Thr Tyr 
            500                 505                 510         


Gly Thr Gly Ala Asp Leu Phe Leu Ile His Pro Ser Thr Gly Leu Ile 
        515                 520                 525             


Tyr Thr Gln Pro Trp Ala Ser Leu Asp Ala Glu Ala Thr Ala Arg Tyr 
    530                 535                 540                 


Asn Phe Tyr Val Lys Ala Glu Asp Met Glu Gly Lys Tyr Ser Val Ala 
545                 550                 555                 560 


Glu Val Phe Ile Thr Leu Leu Asp Val Asn Asp His Pro Pro Gln Phe 
                565                 570                 575     


Gly Lys Ser Val Gln Lys Lys Thr Met Val Leu Gly Thr Pro Val Lys 
            580                 585                 590         


Ile Glu Ala Ile Asp Glu Asp Ala Glu Glu Pro Asn Asn Leu Val Asp 
        595                 600                 605             


Tyr Ser Ile Thr His Ala Glu Pro Ala Asn Val Phe Asp Ile Asn Ser 
    610                 615                 620                 


His Thr Gly Glu Ile Trp Leu Lys Asn Ser Ile Arg Ser Leu Asp Ala 
625                 630                 635                 640 


Leu His Asn Ile Thr Pro Gly Arg Asp Cys Leu Trp Ser Leu Glu Val 
                645                 650                 655     


Gln Ala Lys Asp Arg Gly Ser Pro Ser Phe Ser Thr Thr Ala Leu Leu 
            660                 665                 670         


Lys Ile Asp Ile Thr Asp Ala Glu Thr Leu Ser Arg Ser Pro Met Ala 
        675                 680                 685             


Ala Phe Leu Ile Gln Thr Lys Asp Asn Pro Met Lys Ala Val Gly Val 
    690                 695                 700                 


Leu Ala Gly Thr Met Ala Thr Val Val Ala Ile Thr Val Leu Ile Ser 
705                 710                 715                 720 


Thr Ala Thr Phe Trp Arg Asn Lys Lys Ser Asn Lys Val Leu Pro Met 
                725                 730                 735     


Arg Arg Val Leu Arg Lys Arg Pro Ser Pro Ala Pro Arg Thr Ile Arg 
            740                 745                 750         


Ile Glu Trp Leu Lys Ser Lys Ser Thr Lys Ala Ala Thr Lys Phe Met 
        755                 760                 765             


Leu Lys Glu Lys Pro Pro Asn Glu Asn Cys Asn Asn Asn Ser Pro Glu 
    770                 775                 780                 


Ser Ser Leu Leu Pro Arg Ala Pro Ala Leu Pro Pro Pro Pro Ser Val 
785                 790                 795                 800 


Ala Pro Ser Thr Gly Ala Ala Gln Trp Thr Val Pro Thr Val Ser Gly 
                805                 810                 815     


Ser Leu Thr Pro Gln Pro Thr Gln Pro Pro Pro Lys Pro Lys Thr Met 
            820                 825                 830         


Gly Ser Pro Val Gln Ser Thr Leu Ile Ser Glu Leu Lys Gln Lys Phe 
        835                 840                 845             


Glu Lys Lys Ser Val His Asn Lys Ala Tyr Phe 
    850                 855                 


<210>  2535
<211>  135
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2535

Xaa Glu Asn Ser Ala Ala Ile Asp Phe Glu Lys Ser Lys Val Leu Thr 
1               5                   10                  15      


Phe Lys Leu Leu Ala Val Glu Val Asn Thr Pro Glu Lys Phe Ser Ser 
            20                  25                  30          


Thr Ala Asp Val Val Ile Gln Leu Leu Asp Thr Asn Asp Asn Val Pro 
        35                  40                  45              


Lys Phe Asp Ser Leu Tyr Tyr Val Ala Arg Ile Pro Glu Asn Ala Pro 
    50                  55                  60                  


Gly Gly Ser Ser Val Val Ala Val Thr Ala Val Asp Pro Asp Thr Gly 
65                  70                  75                  80  


Pro Trp Gly Glu Val Lys Tyr Ser Thr Tyr Gly Thr Gly Ala Asp Leu 
                85                  90                  95      


Phe Leu Ile His Pro Ser Thr Gly Leu Ile Tyr Thr Gln Pro Trp Ala 
            100                 105                 110         


Ser Leu Asp Ala Glu Ala Thr Ala Arg Tyr Asn Phe Tyr Val Lys Ala 
        115                 120                 125             


Glu Asp Met Glu Gly Lys Pro 
    130                 135 


<210>  2536
<211>  78
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2536

Xaa Ile Thr His Ala Glu Pro Ala Asn Val Phe Asp Ile Asn Ser His 
1               5                   10                  15      


Thr Gly Glu Ile Trp Leu Lys Asn Ser Ile Arg Ser Leu Asp Ala Leu 
            20                  25                  30          


His Asn Ile Thr Pro Gly Arg Asp Cys Leu Trp Ser Leu Glu Val Gln 
        35                  40                  45              


Ala Lys Asp Arg Gly Ser Pro Ser Phe Ser Thr Thr Ala Leu Leu Lys 
    50                  55                  60                  


Ile Asp Ile Thr Asp Ala Glu Val Arg Arg Leu Arg Ser Asn 
65                  70                  75              


<210>  2537
<211>  598
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2537

Xaa Ile Thr Val Val Ala Lys Asp Gly Gly Gly Arg Leu His Gly Ala 
1               5                   10                  15      


Asp Val Val Phe Ser Ala Thr Thr Thr Val Thr Val Asn Val Glu Asp 
            20                  25                  30          


Val Gln Asp Met Ala Pro Val Phe Val Gly Thr Pro Tyr Tyr Gly Tyr 
        35                  40                  45              


Val Tyr Glu Asp Thr Leu Pro Gly Ser Glu Val Leu Lys Val Val Ala 
    50                  55                  60                  


Met Asp Gly Asp Arg Gly Lys Pro Asn Arg Ile Leu Tyr Ser Leu Val 
65                  70                  75                  80  


Asn Gly Asn Asp Gly Ala Phe Glu Ile Asn Glu Thr Ser Gly Ala Ile 
                85                  90                  95      


Ser Ile Thr Gln Ser Pro Ala Gln Leu Gln Arg Glu Val Tyr Glu Leu 
            100                 105                 110         


His Val Gln Val Thr Glu Met Ser Pro Ala Gly Ser Pro Ala Ala Gln 
        115                 120                 125             


Ala Thr Val Pro Val Thr Ile Arg Ile Val Asp Leu Asn Asn His Pro 
    130                 135                 140                 


Pro Thr Phe Tyr Gly Glu Ser Gly Pro Gln Asn Arg Phe Glu Leu Ser 
145                 150                 155                 160 


Met Asn Glu His Pro Pro Gln Gly Glu Ile Leu Arg Gly Leu Lys Ile 
                165                 170                 175     


Thr Val Asn Asp Ser Asp Gln Gly Ala Asn Ala Lys Phe Asn Leu Gln 
            180                 185                 190         


Leu Val Gly Pro Arg Gly Ile Phe Arg Val Val Pro Gln Thr Val Leu 
        195                 200                 205             


Asn Glu Ala Gln Val Thr Ile Ile Val Glu Asn Ser Ala Ala Ile Asp 
    210                 215                 220                 


Phe Glu Lys Ser Lys Val Leu Thr Phe Lys Ala Val Asp Pro Asp Thr 
225                 230                 235                 240 


Gly Pro Trp Gly Glu Val Lys Tyr Ser Thr Tyr Gly Thr Gly Ala Asp 
                245                 250                 255     


Leu Phe Leu Ile His Pro Ser Thr Gly Leu Ile Tyr Thr Gln Pro Trp 
            260                 265                 270         


Ala Ser Leu Asp Ala Glu Ala Thr Ala Arg Tyr Asn Phe Tyr Val Lys 
        275                 280                 285             


Ala Glu Asp Met Glu Gly Lys Tyr Ser Val Ala Glu Val Phe Ile Thr 
    290                 295                 300                 


Leu Leu Asp Val Asn Asp His Pro Pro Gln Phe Gly Lys Ser Val Gln 
305                 310                 315                 320 


Lys Lys Thr Met Val Leu Gly Thr Pro Val Lys Ile Glu Ala Ile Asp 
                325                 330                 335     


Glu Asp Ala Glu Glu Pro Asn Asn Leu Val Asp Tyr Ser Ile Thr His 
            340                 345                 350         


Ala Glu Pro Ala Asn Val Phe Asp Ile Asn Ser His Thr Gly Glu Ile 
        355                 360                 365             


Trp Leu Lys Asn Ser Ile Arg Ser Leu Asp Ala Leu His Asn Ile Thr 
    370                 375                 380                 


Pro Gly Arg Asp Cys Leu Trp Ser Leu Glu Val Gln Ala Lys Asp Arg 
385                 390                 395                 400 


Gly Ser Pro Ser Phe Ser Thr Thr Ala Leu Leu Lys Ile Asp Ile Thr 
                405                 410                 415     


Asp Ala Glu Thr Leu Ser Arg Ser Pro Met Ala Ala Phe Leu Ile Gln 
            420                 425                 430         


Thr Lys Asp Asn Pro Met Lys Ala Val Gly Val Leu Ala Gly Thr Met 
        435                 440                 445             


Ala Thr Val Val Ala Ile Thr Val Leu Ile Ser Thr Ala Thr Phe Trp 
    450                 455                 460                 


Arg Asn Lys Lys Ser Asn Lys Val Leu Pro Met Arg Arg Val Leu Arg 
465                 470                 475                 480 


Lys Arg Pro Ser Pro Ala Pro Arg Thr Ile Arg Ile Glu Trp Leu Lys 
                485                 490                 495     


Ser Lys Ser Thr Lys Ala Ala Thr Lys Phe Met Leu Lys Glu Lys Pro 
            500                 505                 510         


Pro Asn Glu Asn Cys Asn Asn Asn Ser Pro Glu Ser Ser Leu Leu Pro 
        515                 520                 525             


Arg Ala Pro Ala Leu Pro Pro Pro Pro Ser Val Ala Pro Ser Thr Gly 
    530                 535                 540                 


Ala Ala Gln Trp Thr Val Pro Thr Val Ser Gly Ser Leu Thr Pro Gln 
545                 550                 555                 560 


Pro Thr Gln Pro Pro Pro Lys Pro Lys Thr Met Gly Ser Pro Val Gln 
                565                 570                 575     


Ser Thr Leu Ile Ser Glu Leu Lys Gln Lys Phe Glu Lys Lys Ser Val 
            580                 585                 590         


His Asn Lys Ala Tyr Phe 
        595             


<210>  2538
<211>  48
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2538

Xaa Met Asp Gly Asp Arg Gly Lys Pro Asn Arg Ile Leu Tyr Ser Leu 
1               5                   10                  15      


Val Asn Asp Phe Pro Arg Gln Cys Arg Thr Ile Leu Trp His Asp Ser 
            20                  25                  30          


Pro Ala Pro Pro Cys Gly Pro Val Gln Asn Phe Arg Val His Leu Pro 
        35                  40                  45              


<210>  2539
<211>  788
<212>  PRT
<213>  Homo Sapiens

<400>  2539

Met Val Leu Leu Arg Leu Leu Val Phe Leu Phe Ala Pro Val Val Ser 
1               5                   10                  15      


Asp Leu Cys Ser Leu Pro Cys Phe Ile Asn Val Ser Glu Ser Gln Gly 
            20                  25                  30          


Pro Gly Thr Val Leu Gln Phe Leu Ser Phe Asn Cys Ser Ser Tyr Thr 
        35                  40                  45              


Pro Thr Pro Thr Leu Glu Leu Leu Asn Val Gln Pro Pro Thr Thr Phe 
    50                  55                  60                  


Phe Asn Pro Pro Ser Leu Ala Arg Trp Gln Gly Thr Tyr Val Gly Lys 
65                  70                  75                  80  


Leu Thr Leu Ser Ser Ser Ala Gln Leu Asp Ala Leu Met Val Asn His 
                85                  90                  95      


Tyr Lys Val Gln Leu Lys Phe Thr Cys Gly Asn His Val Met Glu Gly 
            100                 105                 110         


Ser Leu Ser Val Asp Val Gln Arg Asp Leu Ser His Ile Gln Cys Ala 
        115                 120                 125             


Gly Gln Phe Ala Ser Pro Ala Gly Glu Met Ile Gln Val Pro Glu Thr 
    130                 135                 140                 


Val Thr Pro Gly Ala Arg Leu Tyr Thr Leu Leu Leu Pro Gly Leu Glu 
145                 150                 155                 160 


Leu His Gly Ala Gln Met Ser Ile Ile Ser Ala Gln Asp Leu Pro His 
                165                 170                 175     


Phe Pro Gly Pro Phe Ser Ile Asn Glu Gln Gly Trp Leu Gln Ala Pro 
            180                 185                 190         


Ser Gln Gly Leu Leu Gly Gln Ala Gln Lys Val Phe Gln Leu Gln Ile 
        195                 200                 205             


Ser Val Ser Phe Gly Gln Arg Gln Ser Cys Gln Gly Met Val Ile Val 
    210                 215                 220                 


Lys Val Leu Pro Val Pro Ser Ser Gln Val Ser Phe Leu Glu Gln Ala 
225                 230                 235                 240 


Gln Asn Ile Thr Ile Pro Glu Asn Leu Ala Pro Gly Ser Glu Val Val 
                245                 250                 255     


Gln Val Gln Ala Arg Gly Val Asp Leu Arg Tyr Glu Ile Leu Ser Pro 
            260                 265                 270         


Val Pro Ser Pro Leu Phe Ser Ile Gly Arg Ala Asp Gly Val Val Arg 
        275                 280                 285             


Thr Thr Thr Pro Leu Glu Leu Ala Arg Thr Ser Gly Thr Ala Val Ser 
    290                 295                 300                 


Arg Leu Gln Val Lys Ala Phe Glu Gln Gly Gln Leu Trp Ala Ser Ala 
305                 310                 315                 320 


Lys Leu Asn Leu Thr Met Asn Val Gln Leu Val Asn Leu Trp Pro Pro 
                325                 330                 335     


Arg Cys Leu Pro Ala Leu Leu Val Ser Gln Ile Pro Glu Thr Ala Pro 
            340                 345                 350         


Val Gly Thr Val Leu Asn Thr Leu Thr Cys Glu Asp Pro Asp Ser Val 
        355                 360                 365             


Gly Ala Thr Leu Asp Tyr Lys Leu Trp Phe Arg Ser Ser Ser Asn Pro 
    370                 375                 380                 


Ala Ser Leu Cys Leu Tyr Asp Arg Val Leu Glu Val Asn Ala Thr Leu 
385                 390                 395                 400 


Asp Cys Asp Thr Pro Gly Ala Cys Phe Gln His Ala Ala Ser Ile Leu 
                405                 410                 415     


Val Leu Asp Gly Gly Gln Pro Gln Met Thr Thr Glu Val Pro Val Leu 
            420                 425                 430         


Val Met Val Thr Pro Ile Asn Glu Phe Ser Pro Ala Cys Ala Pro Arg 
        435                 440                 445             


Thr Phe Arg Val Gln Glu Asp Ala Ala Pro His Thr Leu Leu Gly Ser 
    450                 455                 460                 


Val Val Gly Thr Asp Met Asp Tyr Pro His Asp Asn Ile Glu Tyr Tyr 
465                 470                 475                 480 


Thr Ser Gly Gly Pro Thr Thr Phe Ala Val Asp Arg Leu Ser Gly Glu 
                485                 490                 495     


Val His Leu Leu Gly Pro Leu Asp Tyr Glu Gln Gln Arg Leu Tyr Arg 
            500                 505                 510         


Leu Thr Val Leu Val Ile Asp His Gly Gln Asp Gln Asn Pro Asn His 
        515                 520                 525             


His Leu Ser Gly Ser Cys Thr Ile Thr Ile Glu Val Glu Asp Val Asn 
    530                 535                 540                 


Asp His Ala Pro Glu Cys Glu Pro Pro Phe Gln Glu Leu Thr Ile Tyr 
545                 550                 555                 560 


Ala Pro Leu Gly Arg Ser Val Glu Val Thr Lys Met Ser Cys Gln Ile 
                565                 570                 575     


Pro Gln Glu Pro Gln Arg Leu Ile Tyr Ser Tyr Ser Ile Val Gly Gly 
            580                 585                 590         


Asn Ser Gln Asn Arg Phe Ile Leu Gln Gly Ala Ile Leu Val His Ser 
        595                 600                 605             


Asp Leu Val Leu Gly Pro Phe Trp Pro Glu Gln Pro Arg Thr Tyr Glu 
    610                 615                 620                 


Leu Leu Ile Cys Val Ala Asp Ala Gly Pro Ser Thr Pro His Leu Ser 
625                 630                 635                 640 


Thr Thr Ala Thr Ile Ile Val His Leu Val Pro Arg Arg Ala Ser Thr 
                645                 650                 655     


Val Ala Thr Ser Thr His Arg Thr Thr Val Pro Ser Thr Met Thr Pro 
            660                 665                 670         


Met Leu Val Thr Asp Thr Glu Ala Phe Trp Gln Pro Gln Pro Trp Phe 
        675                 680                 685             


Val Val Val Leu Thr Ala Thr Gly Ala Leu Leu Leu Leu Ala Leu Gly 
    690                 695                 700                 


Trp Leu Leu Gly Arg Leu Leu Gln Gly Leu Ala Gln Leu Leu Gln Ala 
705                 710                 715                 720 


Pro Ser Lys Pro Ala Gln Ala Leu Leu Leu Asn Ser Ile Gln Gly Thr 
                725                 730                 735     


Glu Gly Ser Ile Glu Gly Phe Leu Glu Ala Pro Lys Met Glu Met Ser 
            740                 745                 750         


Gln Ala Pro Ser Ser Val Met Ser Leu His Phe Asp Gly Arg Ala Gln 
        755                 760                 765             


Asp Ser Arg Thr Gly Arg Asp Tyr Leu Phe Asn Thr His Thr Gly Ala 
    770                 775                 780                 


Arg Arg Trp Leu 
785             


<210>  2540
<211>  184
<212>  PRT
<213>  Homo Sapiens

<400>  2540

Met Val Leu Leu Arg Leu Leu Val Phe Leu Phe Ala Pro Val Val Ser 
1               5                   10                  15      


Asp Leu Cys Ser Leu Pro Cys Phe Ile Asn Val Ser Glu Ser Gln Gly 
            20                  25                  30          


Pro Gly Thr Val Leu Gln Phe Leu Ser Phe Asn Cys Ser Ser Tyr Thr 
        35                  40                  45              


Pro Thr Pro Thr Leu Glu Leu Leu Asn Val Gln Pro Pro Thr Thr Phe 
    50                  55                  60                  


Phe Asn Pro Pro Ser Leu Ala Arg Trp Gln Gly Thr Tyr Val Gly Lys 
65                  70                  75                  80  


Leu Thr Leu Ser Ser Ser Ala Gln Leu Asp Ala Leu Met Val Asn His 
                85                  90                  95      


Tyr Lys Val Gln Leu Lys Phe Thr Cys Gly Asn His Val Met Glu Gly 
            100                 105                 110         


Ser Leu Ser Val Asp Val Gln Arg Asp Leu Ser His Ile Gln Cys Ala 
        115                 120                 125             


Gly Gln Phe Ala Ser Pro Ala Gly Glu Met Ile Gln Val Pro Glu Thr 
    130                 135                 140                 


Val Thr Pro Gly Ala Arg Leu Tyr Thr Leu Leu Leu Pro Gly Leu Glu 
145                 150                 155                 160 


Leu His Gly Ala Gln Val Ser Pro Glu His Gly Thr Val Gly Asp Arg 
                165                 170                 175     


Met Gly Val Gly Gly Trp Arg Glu 
            180                 


<210>  2541
<211>  199
<212>  PRT
<213>  Homo Sapiens

<400>  2541

Met Val Leu Leu Arg Leu Leu Val Phe Leu Phe Ala Pro Val Val Ser 
1               5                   10                  15      


Asp Leu Cys Ser Leu Pro Cys Phe Ile Asn Val Ser Glu Ser Gln Gly 
            20                  25                  30          


Pro Gly Thr Val Leu Gln Phe Leu Ser Phe Asn Cys Ser Ser Tyr Thr 
        35                  40                  45              


Pro Thr Pro Thr Leu Glu Leu Leu Asn Val Gln Pro Pro Thr Thr Phe 
    50                  55                  60                  


Phe Asn Pro Pro Ser Leu Ala Arg Trp Gln Gly Thr Tyr Val Gly Lys 
65                  70                  75                  80  


Leu Thr Leu Ser Ser Ser Ala Gln Leu Asp Ala Leu Met Val Asn His 
                85                  90                  95      


Tyr Lys Val Gln Leu Lys Phe Thr Cys Gly Asn His Val Met Glu Gly 
            100                 105                 110         


Ser Leu Ser Val Asp Val Gln Arg Asp Leu Ser His Ile Gln Cys Ala 
        115                 120                 125             


Gly Gln Phe Ala Ser Pro Gly Glu Ala Arg Gly Ser Arg Gln Gly Gly 
    130                 135                 140                 


Gly Arg His Gly Leu Ser Arg Ser Ser Leu Thr Ser Thr Leu Ala Ser 
145                 150                 155                 160 


Trp Gly Asn Asp Ser Gly Ala Arg Asp Ser His Thr Trp Gly Ser Ala 
                165                 170                 175     


Val His Ser Ala Pro Pro Arg Pro Arg Thr Pro Arg Ser Ala Gly Lys 
            180                 185                 190         


Pro Arg Thr Trp Asp Gly Gly 
        195                 


<210>  2542
<211>  134
<212>  PRT
<213>  Homo Sapiens

<400>  2542

Gln Glu Leu Thr Ile Tyr Ala Pro Leu Gly Arg Ser Val Glu Val Thr 
1               5                   10                  15      


Lys Met Ser Cys Gln Ile Pro Gln Glu Pro Gln Arg Leu Ile Tyr Ser 
            20                  25                  30          


Tyr Ser Ile Val Gly Gly Asn Ser Gln Asn Arg Phe Ile Leu Gln Gly 
        35                  40                  45              


Ala Ile Leu Val His Ser Asp Leu Val Leu Gly Pro Phe Trp Pro Glu 
    50                  55                  60                  


Gln Pro Arg Thr Tyr Glu Leu Leu Ile Cys Val Ala Asp Ala Gly Pro 
65                  70                  75                  80  


Ser Thr Pro His Leu Ser Thr Thr Ala Thr Ile Ile Val His Leu Val 
                85                  90                  95      


Pro Arg Arg Ala Ser Thr Val Ala Thr Ser Thr His Arg Thr Thr Val 
            100                 105                 110         


Gly Pro Ala Ala Ala Ser Thr Gln Gln Thr Ser Pro Gly Phe Ala Ala 
        115                 120                 125             


Lys Gln His Pro Gly Asn 
    130                 


<210>  2543
<211>  151
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2543

Xaa Ser Thr Thr Ala Thr Ile Ile Val His Leu Val Pro Arg Arg Ala 
1               5                   10                  15      


Ser Thr Val Ala Thr Ser Thr His Arg Thr Thr Val Pro Ser Thr Met 
            20                  25                  30          


Thr Pro Met Leu Val Thr Asp Thr Glu Ala Phe Trp Gln Pro Gln Pro 
        35                  40                  45              


Trp Phe Val Val Val Leu Thr Ala Thr Gly Ala Leu Leu Leu Leu Ala 
    50                  55                  60                  


Leu Gly Trp Leu Leu Gly Arg Leu Leu Gln Gly Leu Ala Gln Leu Leu 
65                  70                  75                  80  


Gln Ala Pro Ser Lys Pro Ala Gln Ala Leu Leu Leu Asn Ser Ile Gln 
                85                  90                  95      


Gly Thr Glu Gly Ser Ile Glu Gly Phe Leu Glu Ala Pro Lys Met Glu 
            100                 105                 110         


Met Ser Gln Ala Pro Ser Ser Val Met Ser Leu Gln His Phe Asp Gly 
        115                 120                 125             


Arg Ala Gln Asp Ser Arg Thr Gly Arg Asp Tyr Leu Phe Asn Thr His 
    130                 135                 140                 


Thr Gly Ala Arg Arg Trp Leu 
145                 150     


<210>  2544
<211>  190
<212>  PRT
<213>  Homo Sapiens

<400>  2544

Met Gly Ser Trp Ala Leu Leu Trp Pro Pro Leu Leu Phe Thr Gly Leu 
1               5                   10                  15      


Leu Val Arg Pro Pro Gly Thr Met Ala Gln Ala Gln Tyr Cys Ser Val 
            20                  25                  30          


Asn Lys Asp Ile Phe Glu Val Glu Glu Asn Thr Asn Val Thr Glu Pro 
        35                  40                  45              


Leu Val Asp Ile His Val Pro Glu Gly Gln Glu Val Thr Leu Gly Ala 
    50                  55                  60                  


Leu Ser Thr Pro Phe Ala Phe Arg Ile Gln Gly Asn Gln Leu Phe Leu 
65                  70                  75                  80  


Asn Val Thr Pro Asp Tyr Glu Glu Lys Ser Leu Leu Glu Ala Gln Leu 
                85                  90                  95      


Leu Cys Gln Ser Gly Gly Thr Leu Asp Thr Lys Val Asn Ser Thr Val 
            100                 105                 110         


Ile Pro Glu Thr Gln Leu Gln Ala Glu Asp Arg Asp Lys Asp Asp Ile 
        115                 120                 125             


Leu Phe Tyr Thr Leu Gln Glu Met Thr Ala Gly Ala Ser Asp Tyr Phe 
    130                 135                 140                 


Ser Leu Val Ser Val Asn Arg Pro Ala Leu Arg Leu Asp Arg Pro Leu 
145                 150                 155                 160 


Asp Phe Tyr Glu Arg Pro Asn Met Thr Phe Trp Leu Leu Val Arg Pro 
                165                 170                 175     


Ser Val Ala Gly His Ser Gly Gly Glu Cys Gly Thr Gln Pro 
            180                 185                 190 


<210>  2545
<211>  166
<212>  PRT
<213>  Homo Sapiens

<400>  2545

Met Gly Ser Trp Ala Leu Leu Trp Pro Pro Leu Leu Phe Thr Gly Leu 
1               5                   10                  15      


Leu Val Arg Pro Pro Gly Thr Met Ala Gln Ala Gln Tyr Cys Ser Val 
            20                  25                  30          


Asn Lys Asp Ile Phe Glu Val Glu Glu Asn Thr Asn Val Thr Glu Pro 
        35                  40                  45              


Leu Val Asp Ile His Val Pro Glu Gly Gln Glu Val Thr Leu Gly Ala 
    50                  55                  60                  


Leu Ser Thr Pro Phe Ala Phe Arg Ile Gln Gly Asn Gln Leu Phe Leu 
65                  70                  75                  80  


Asn Val Thr Pro Asp Tyr Glu Glu Lys Ser Leu Leu Glu Ala Gln Leu 
                85                  90                  95      


Leu Cys Gln Ser Gly Gly Thr Leu Thr Lys Glu Ile Arg Val Glu Glu 
            100                 105                 110         


Asp Thr Lys Val Asn Ser Thr Val Ile Pro Glu Thr Gln Leu Gln Ala 
        115                 120                 125             


Glu Asp Arg Asp Lys Asp Asp Ile Leu Phe Tyr Thr Leu Gln Glu Met 
    130                 135                 140                 


Thr Ala Gly Ala Ser Asp Tyr Phe Ser Leu Val Ser Val Asn Arg Pro 
145                 150                 155                 160 


Ala Leu Arg Leu Asp Arg 
                165     


<210>  2546
<211>  651
<212>  PRT
<213>  Homo Sapiens

<400>  2546

Met Gly Ser Trp Ala Leu Leu Trp Pro Pro Leu Leu Phe Thr Gly Leu 
1               5                   10                  15      


Leu Val Arg Pro Pro Gly Thr Met Ala Gln Ala Gln Tyr Cys Ser Val 
            20                  25                  30          


Asn Lys Asp Ile Phe Glu Val Glu Glu Asn Thr Asn Val Thr Glu Pro 
        35                  40                  45              


Leu Val Asp Ile His Val Pro Glu Gly Gln Glu Val Thr Leu Gly Ala 
    50                  55                  60                  


Leu Ser Thr Pro Phe Ala Phe Arg Ile Gln Gly Asn Gln Leu Phe Leu 
65                  70                  75                  80  


Asn Val Thr Pro Asp Tyr Glu Glu Lys Ser Leu Leu Glu Ala Gln Leu 
                85                  90                  95      


Leu Cys Gln Ser Gly Gly Thr Leu Val Thr Gln Leu Arg Val Phe Val 
            100                 105                 110         


Ser Val Leu Asp Val Asn Asp Asn Ala Pro Glu Phe Pro Phe Lys Thr 
        115                 120                 125             


Lys Glu Ile Arg Val Glu Glu Asp Thr Lys Val Asn Ser Thr Val Ile 
    130                 135                 140                 


Pro Glu Thr Gln Leu Gln Ala Glu Asp Arg Asp Lys Asp Asp Ile Leu 
145                 150                 155                 160 


Phe Tyr Thr Leu Gln Glu Met Thr Ala Gly Ala Ser Asp Tyr Phe Ser 
                165                 170                 175     


Leu Val Ser Val Asn Arg Pro Ala Leu Arg Leu Asp Arg Pro Leu Asp 
            180                 185                 190         


Phe Tyr Glu Arg Pro Asn Met Thr Phe Trp Leu Leu Val Arg Asp Thr 
        195                 200                 205             


Pro Gly Glu Asn Val Glu Pro Ser His Thr Ala Thr Ala Thr Leu Val 
    210                 215                 220                 


Leu Asn Val Val Pro Ala Asp Leu Arg Pro Pro Trp Phe Leu Pro Cys 
225                 230                 235                 240 


Thr Phe Ser Asp Gly Tyr Val Cys Ile Gln Ala Gln Tyr His Gly Ala 
                245                 250                 255     


Val Pro Thr Gly His Ile Leu Pro Ser Pro Leu Val Leu Arg Pro Gly 
            260                 265                 270         


Pro Ile Tyr Ala Glu Asp Gly Asp Arg Gly Ile Asn Gln Pro Ile Ile 
        275                 280                 285             


Tyr Ser Ile Phe Arg Gly Asn Val Asn Gly Thr Phe Ile Ile His Pro 
    290                 295                 300                 


Asp Ser Gly Asn Leu Thr Val Ala Arg Ser Val Pro Ser Pro Met Thr 
305                 310                 315                 320 


Phe Leu Leu Leu Val Lys Gly Gln Gln Ala Asp Leu Ala Arg Tyr Ser 
                325                 330                 335     


Val Thr Gln Val Thr Val Glu Ala Val Ala Ala Ala Gly Ser Pro Pro 
            340                 345                 350         


Arg Phe Pro Gln Arg Leu Tyr Arg Gly Thr Val Ala Arg Gly Ala Gly 
        355                 360                 365             


Ala Gly Val Val Val Lys Asp Ala Ala Ala Pro Ser Gln Pro Leu Arg 
    370                 375                 380                 


Ile Gln Ala Gln Asp Pro Glu Phe Ser Asp Leu Asn Ser Ala Ile Thr 
385                 390                 395                 400 


Tyr Arg Ile Thr Asn His Ser His Phe Arg Met Glu Gly Glu Val Val 
                405                 410                 415     


Leu Thr Thr Thr Thr Leu Ala Gln Ala Gly Ala Phe Tyr Ala Glu Val 
            420                 425                 430         


Glu Ala His Asn Thr Val Thr Ser Gly Thr Ala Thr Thr Val Ile Glu 
        435                 440                 445             


Ile Gln Val Ser Glu Gln Glu Pro Pro Ser Thr Gly Gly Gly Pro Ser 
    450                 455                 460                 


Glu Asp Lys Arg Phe Ser Val Val Asp Met Ala Ala Leu Gly Gly Val 
465                 470                 475                 480 


Leu Gly Ala Leu Leu Leu Leu Ala Leu Leu Gly Leu Ala Val Leu Val 
                485                 490                 495     


His Lys His Tyr Gly Pro Arg Leu Lys Cys Cys Cys Gly Lys Ala Pro 
            500                 505                 510         


Glu Pro Gln Pro Gln Gly Phe Asp Asn Gln Ala Phe Leu Pro Asp His 
        515                 520                 525             


Lys Ala Asn Trp Ala Pro Val Pro Ser Pro Thr His Asp Pro Lys Pro 
    530                 535                 540                 


Ala Glu Ala Pro Met Pro Ala Glu Pro Ala Pro Pro Gly Pro Ala Ser 
545                 550                 555                 560 


Pro Gly Gly Ala Pro Glu Pro Pro Ala Ala Ala Arg Ala Gly Gly Ser 
                565                 570                 575     


Pro Thr Ala Val Arg Ser Ile Leu Thr Lys Glu Arg Arg Pro Glu Gly 
            580                 585                 590         


Gly Tyr Lys Ala Val Trp Phe Gly Glu Asp Ile Gly Thr Glu Ala Asp 
        595                 600                 605             


Val Val Val Leu Asn Ala Pro Thr Leu Asp Val Asp Gly Ala Ser Asp 
    610                 615                 620                 


Ser Gly Ser Gly Asp Glu Gly Glu Gly Ala Gly Arg Gly Gly Gly Pro 
625                 630                 635                 640 


Tyr Asp Ala Pro Gly Gly Asp Asp Ser Tyr Ile 
                645                 650     


<210>  2547
<211>  845
<212>  PRT
<213>  Homo Sapiens

<400>  2547

Met Gly Ser Trp Ala Leu Leu Trp Pro Pro Leu Leu Phe Thr Gly Leu 
1               5                   10                  15      


Leu Val Arg Pro Pro Gly Thr Met Ala Gln Ala Gln Tyr Cys Ser Val 
            20                  25                  30          


Asn Lys Asp Ile Phe Glu Val Glu Glu Asn Thr Asn Val Thr Glu Pro 
        35                  40                  45              


Leu Val Asp Ile His Val Pro Glu Gly Gln Glu Val Thr Leu Gly Ala 
    50                  55                  60                  


Leu Ser Thr Pro Phe Ala Phe Arg Ile Gln Gly Asn Gln Leu Phe Leu 
65                  70                  75                  80  


Asn Val Thr Pro Asp Tyr Glu Glu Lys Ser Leu Leu Glu Ala Gln Leu 
                85                  90                  95      


Leu Cys Gln Ser Gly Gly Thr Leu Val Thr Gln Leu Arg Val Phe Val 
            100                 105                 110         


Ser Val Leu Asp Val Asn Asp Asn Ala Pro Glu Phe Pro Phe Lys Thr 
        115                 120                 125             


Lys Glu Ile Arg Val Glu Glu Asp Thr Lys Val Asn Ser Thr Val Ile 
    130                 135                 140                 


Pro Glu Thr Gln Leu Gln Ala Glu Asp Arg Asp Lys Asp Asp Ile Leu 
145                 150                 155                 160 


Phe Tyr Thr Leu Gln Glu Met Thr Ala Gly Ala Ser Asp Tyr Phe Ser 
                165                 170                 175     


Leu Val Ser Val Asn Arg Pro Ala Leu Arg Leu Asp Arg Pro Leu Asp 
            180                 185                 190         


Phe Tyr Glu Arg Pro Asn Met Thr Phe Trp Leu Leu Val Arg Asp Thr 
        195                 200                 205             


Pro Gly Glu Asn Val Glu Pro Ser His Thr Ala Thr Ala Thr Leu Val 
    210                 215                 220                 


Leu Asn Val Val Pro Ala Asp Leu Arg Pro Pro Trp Phe Leu Pro Cys 
225                 230                 235                 240 


Thr Phe Ser Asp Gly Tyr Val Cys Ile Gln Ala Gln Tyr His Gly Ala 
                245                 250                 255     


Val Pro Thr Gly His Ile Leu Pro Ser Pro Leu Val Leu Arg Pro Gly 
            260                 265                 270         


Pro Ile Tyr Ala Glu Asp Gly Asp Arg Gly Ile Asn Gln Pro Ile Ile 
        275                 280                 285             


Tyr Ser Ile Phe Arg Gly Asn Val Asn Gly Thr Phe Ile Ile His Pro 
    290                 295                 300                 


Asp Ser Gly Asn Leu Thr Val Ala Arg Ser Val Pro Ser Pro Met Thr 
305                 310                 315                 320 


Phe Leu Leu Leu Val Lys Gly Gln Gln Ala Asp Leu Ala Arg Tyr Ser 
                325                 330                 335     


Val Thr Gln Val Thr Val Glu Ala Val Ala Ala Ala Gly Ser Pro Pro 
            340                 345                 350         


Arg Phe Pro Gln Arg Leu Tyr Arg Gly Thr Val Ala Arg Gly Ala Gly 
        355                 360                 365             


Ala Gly Val Val Val Lys Asp Ala Ala Ala Pro Ser Gln Pro Leu Arg 
    370                 375                 380                 


Ile Gln Ala Gln Asp Pro Glu Phe Ser Asp Leu Asn Ser Ala Ile Thr 
385                 390                 395                 400 


Tyr Arg Ile Thr Asn His Ser His Phe Arg Met Glu Gly Glu Val Val 
                405                 410                 415     


Leu Thr Thr Thr Thr Leu Ala Gln Ala Gly Ala Phe Tyr Ala Glu Val 
            420                 425                 430         


Glu Ala His Asn Thr Val Thr Ser Gly Thr Ala Thr Thr Val Ile Glu 
        435                 440                 445             


Ile Gln Val Ser Glu Gln Glu Pro Pro Ser Thr Asp Val Pro Pro Ser 
    450                 455                 460                 


Pro Glu Ala Gly Gly Thr Thr Gly Pro Trp Thr Ser Thr Thr Ser Glu 
465                 470                 475                 480 


Val Pro Arg Pro Pro Glu Pro Ser Gln Gly Pro Ser Thr Thr Ser Ser 
                485                 490                 495     


Gly Gly Gly Thr Gly Pro His Pro Pro Ser Gly Thr Thr Leu Arg Pro 
            500                 505                 510         


Pro Thr Ser Ser Thr Pro Gly Gly Pro Pro Gly Ala Glu Asn Ser Thr 
        515                 520                 525             


Ser His Gln Pro Ala Thr Pro Gly Gly Asp Thr Ala Gln Thr Pro Lys 
    530                 535                 540                 


Pro Gly Thr Ser Gln Pro Met Pro Pro Gly Val Gly Thr Ser Thr Ser 
545                 550                 555                 560 


His Gln Pro Ala Thr Pro Ser Gly Gly Thr Ala Gln Thr Pro Glu Pro 
                565                 570                 575     


Gly Thr Ser Gln Pro Met Pro Pro Ser Met Gly Thr Ser Thr Ser His 
            580                 585                 590         


Gln Pro Ala Thr Pro Gly Gly Gly Thr Ala Gln Thr Pro Glu Ala Gly 
        595                 600                 605             


Thr Ser Gln Pro Met Pro Pro Gly Met Gly Thr Ser Thr Ser His Gln 
    610                 615                 620                 


Pro Thr Thr Pro Gly Gly Gly Thr Ala Gln Thr Pro Glu Pro Gly Thr 
625                 630                 635                 640 


Ser Gln Pro Met Pro Leu Ser Lys Ser Thr Pro Ser Ser Gly Gly Gly 
                645                 650                 655     


Pro Ser Glu Asp Lys Arg Phe Ser Val Val Asp Met Ala Ala Leu Gly 
            660                 665                 670         


Gly Val Leu Gly Ala Leu Leu Leu Leu Ala Leu Leu Gly Leu Ala Val 
        675                 680                 685             


Leu Val His Lys His Tyr Gly Pro Arg Leu Lys Cys Cys Cys Gly Lys 
    690                 695                 700                 


Ala Pro Glu Pro Gln Pro Gln Gly Phe Asp Asn Gln Ala Phe Leu Pro 
705                 710                 715                 720 


Asp His Lys Ala Asn Trp Ala Pro Val Pro Ser Pro Thr His Asp Pro 
                725                 730                 735     


Lys Pro Ala Glu Ala Pro Met Pro Ala Glu Pro Ala Pro Pro Gly Pro 
            740                 745                 750         


Ala Ser Pro Gly Gly Ala Pro Glu Pro Pro Ala Ala Ala Arg Ala Gly 
        755                 760                 765             


Gly Ser Pro Thr Ala Val Arg Ser Ile Leu Thr Lys Glu Arg Arg Pro 
    770                 775                 780                 


Glu Gly Gly Tyr Lys Ala Val Trp Phe Gly Glu Asp Ile Gly Thr Glu 
785                 790                 795                 800 


Ala Asp Val Val Val Leu Asn Ala Pro Thr Leu Asp Val Asp Gly Ala 
                805                 810                 815     


Ser Asp Ser Gly Ser Gly Asp Glu Gly Glu Gly Ala Gly Arg Gly Gly 
            820                 825                 830         


Gly Pro Tyr Asp Ala Pro Gly Gly Asp Asp Ser Tyr Ile 
        835                 840                 845 


<210>  2548
<211>  845
<212>  PRT
<213>  Homo Sapiens

<400>  2548

Met Gly Ser Trp Ala Leu Leu Trp Pro Pro Leu Leu Phe Thr Gly Leu 
1               5                   10                  15      


Leu Val Arg Pro Pro Gly Thr Met Ala Gln Ala Gln Tyr Cys Ser Val 
            20                  25                  30          


Asn Lys Asp Ile Phe Glu Val Glu Glu Asn Thr Asn Val Thr Glu Pro 
        35                  40                  45              


Leu Val Asp Ile His Val Pro Glu Gly Gln Glu Val Thr Leu Gly Ala 
    50                  55                  60                  


Leu Ser Thr Pro Phe Ala Phe Arg Ile Gln Gly Asn Gln Leu Phe Leu 
65                  70                  75                  80  


Asn Val Thr Pro Asp Tyr Glu Glu Lys Ser Leu Leu Glu Ala Gln Leu 
                85                  90                  95      


Leu Cys Gln Ser Gly Gly Thr Leu Val Thr Gln Leu Arg Val Phe Val 
            100                 105                 110         


Ser Val Leu Asp Val Asn Asp Asn Ala Pro Glu Phe Pro Phe Lys Thr 
        115                 120                 125             


Lys Glu Ile Arg Val Glu Glu Asp Thr Lys Val Asn Ser Thr Val Ile 
    130                 135                 140                 


Pro Glu Thr Gln Leu Gln Ala Glu Asp Arg Asp Lys Asp Asp Ile Leu 
145                 150                 155                 160 


Phe Tyr Thr Leu Gln Glu Met Thr Ala Gly Ala Ser Asp Tyr Phe Ser 
                165                 170                 175     


Leu Val Ser Val Asn Arg Pro Ala Leu Arg Leu Asp Arg Pro Leu Asp 
            180                 185                 190         


Phe Tyr Glu Arg Pro Asn Met Thr Phe Trp Leu Leu Val Arg Asp Thr 
        195                 200                 205             


Pro Gly Glu Asn Val Glu Pro Ser His Thr Ala Thr Ala Thr Leu Val 
    210                 215                 220                 


Leu Asn Val Val Pro Ala Asp Leu Arg Pro Pro Trp Phe Leu Pro Cys 
225                 230                 235                 240 


Thr Phe Ser Asp Gly Tyr Val Cys Ile Gln Ala Gln Tyr His Gly Ala 
                245                 250                 255     


Val Pro Thr Gly His Ile Leu Pro Ser Pro Leu Val Leu Arg Pro Gly 
            260                 265                 270         


Pro Ile Tyr Ala Glu Asp Gly Asp Arg Gly Ile Asn Gln Pro Ile Ile 
        275                 280                 285             


Tyr Ser Ile Phe Arg Gly Asn Val Asn Gly Thr Phe Ile Ile His Pro 
    290                 295                 300                 


Asp Ser Gly Asn Leu Thr Val Ala Arg Ser Val Pro Ser Pro Met Thr 
305                 310                 315                 320 


Phe Leu Leu Leu Val Lys Gly Gln Gln Ala Asp Leu Ala Arg Tyr Ser 
                325                 330                 335     


Val Thr Gln Val Thr Val Glu Ala Val Ala Ala Ala Gly Ser Pro Pro 
            340                 345                 350         


Arg Phe Pro Gln Arg Leu Tyr Arg Gly Thr Val Ala Arg Gly Ala Gly 
        355                 360                 365             


Ala Gly Val Val Val Lys Asp Ala Ala Ala Pro Ser Gln Pro Leu Arg 
    370                 375                 380                 


Ile Gln Ala Gln Asp Pro Glu Phe Ser Asp Leu Asn Ser Ala Ile Thr 
385                 390                 395                 400 


Tyr Arg Ile Thr Asn His Ser His Phe Arg Met Glu Gly Glu Val Val 
                405                 410                 415     


Leu Thr Thr Thr Thr Leu Ala Gln Ala Gly Ala Phe Tyr Ala Glu Val 
            420                 425                 430         


Glu Ala His Asn Thr Val Thr Ser Gly Thr Ala Thr Thr Val Ile Glu 
        435                 440                 445             


Ile Gln Val Ser Glu Gln Glu Pro Pro Ser Thr Asp Val Pro Pro Ser 
    450                 455                 460                 


Pro Glu Ala Gly Gly Thr Thr Gly Pro Trp Thr Ser Thr Thr Ser Glu 
465                 470                 475                 480 


Val Pro Arg Pro Pro Glu Pro Ser Gln Gly Pro Ser Thr Thr Ser Ser 
                485                 490                 495     


Gly Gly Gly Thr Gly Pro His Pro Pro Ser Gly Thr Thr Leu Arg Pro 
            500                 505                 510         


Pro Thr Ser Ser Thr Pro Gly Gly Pro Pro Gly Ala Glu Asn Ser Thr 
        515                 520                 525             


Ser His Gln Pro Ala Thr Pro Gly Gly Asp Thr Ala Gln Thr Pro Lys 
    530                 535                 540                 


Pro Gly Thr Ser Gln Pro Met Pro Pro Gly Val Gly Thr Ser Thr Ser 
545                 550                 555                 560 


His Gln Pro Ala Thr Pro Ser Gly Gly Thr Ala Gln Thr Pro Glu Pro 
                565                 570                 575     


Gly Thr Ser Gln Pro Met Pro Pro Ser Met Gly Thr Ser Thr Ser His 
            580                 585                 590         


Gln Pro Ala Thr Pro Gly Gly Gly Thr Ala Gln Thr Pro Glu Ala Gly 
        595                 600                 605             


Thr Ser Gln Pro Met Pro Pro Gly Met Gly Thr Ser Thr Ser His Gln 
    610                 615                 620                 


Pro Thr Thr Pro Gly Gly Gly Thr Ala Gln Thr Pro Glu Pro Gly Thr 
625                 630                 635                 640 


Ser Gln Pro Met Pro Leu Ser Lys Ser Thr Pro Ser Ser Gly Gly Gly 
                645                 650                 655     


Pro Ser Glu Asp Lys Arg Phe Ser Val Val Asp Met Ala Ala Leu Gly 
            660                 665                 670         


Gly Val Leu Gly Ala Leu Leu Leu Leu Ala Leu Leu Gly Leu Ala Val 
        675                 680                 685             


Leu Val His Lys His Tyr Gly Pro Arg Leu Lys Cys Cys Cys Gly Lys 
    690                 695                 700                 


Ala Pro Glu Pro Gln Pro Gln Gly Phe Asp Asn Gln Ala Phe Leu Pro 
705                 710                 715                 720 


Asp His Lys Ala Asn Trp Ala Pro Val Pro Ser Pro Thr His Asp Pro 
                725                 730                 735     


Lys Pro Ala Glu Ala Pro Met Pro Ala Glu Pro Ala Pro Pro Gly Pro 
            740                 745                 750         


Ala Ser Pro Gly Gly Ala Pro Glu Pro Pro Ala Ala Ala Arg Ala Gly 
        755                 760                 765             


Gly Ser Pro Thr Ala Val Arg Ser Ile Leu Thr Lys Glu Arg Arg Pro 
    770                 775                 780                 


Glu Gly Gly Tyr Lys Ala Val Trp Phe Gly Glu Asp Ile Gly Thr Glu 
785                 790                 795                 800 


Ala Asp Val Val Val Leu Asn Ala Pro Thr Leu Asp Val Asp Gly Ala 
                805                 810                 815     


Ser Asp Ser Gly Ser Gly Asp Glu Gly Glu Gly Ala Gly Arg Gly Gly 
            820                 825                 830         


Gly Pro Tyr Asp Ala Pro Gly Gly Asp Asp Ser Tyr Ile 
        835                 840                 845 


<210>  2549
<211>  106
<212>  PRT
<213>  Homo Sapiens

<400>  2549

Met Gly Ser Trp Ala Leu Leu Trp Pro Pro Leu Leu Phe Thr Gly Leu 
1               5                   10                  15      


Leu Val Arg Pro Pro Gly Thr Met Ala Gln Ala Gln Tyr Cys Ser Val 
            20                  25                  30          


Asn Lys Asp Ile Phe Glu Val Glu Glu Asn Thr Asn Val Thr Glu Pro 
        35                  40                  45              


Leu Val Asp Ile His Val Pro Glu Gly Gln Glu Val Thr Leu Gly Ala 
    50                  55                  60                  


Leu Ser Thr Pro Phe Ala Phe Arg Ile Gln Gly Asn Gln Leu Phe Leu 
65                  70                  75                  80  


Asn Val Thr Pro Asp Tyr Glu Lys Ala Gly Pro Phe Arg Asp Glu Ala 
                85                  90                  95      


Ala Trp Ala His Thr Leu Ser Thr Asp His 
            100                 105     


<210>  2550
<211>  15
<212>  PRT
<213>  Homo Sapiens

<400>  2550

Met Thr Ala Gly Ala Ser Asp Tyr Phe Ser Leu Val Ser Val Asn 
1               5                   10                  15  


<210>  2551
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  2551

Met Glu Pro Ala Ala Gly Ser Ser Met Glu Pro Ser Ala Asp Trp Leu 
1               5                   10                  15      


Ala Thr Ala Ala Ala Arg Gly Arg Val Glu Glu Val Arg Ala Leu Leu 
            20                  25                  30          


Glu Ala Gly Ala Leu Pro Asn Ala Pro Asn Ser Tyr Gly Arg Arg Pro 
        35                  40                  45              


Ile Gln Val Gly Arg Gly Ser Ala Ala Gly Ala Gly Asp Gly Gly Arg 
    50                  55                  60                  


Leu Trp Arg Thr Lys Phe Ala Gly Glu Leu Glu Ser Gly Ser Ala Ser 
65                  70                  75                  80  


Ile Leu Arg Lys Lys Gly Arg Leu Pro Gly Glu Phe Ser Glu Gly Val 
                85                  90                  95      


Cys Asn His Arg Pro Pro Pro Gly Asp Ala Leu Gly Ala Trp Glu Ala 
            100                 105                 110         


Lys Glu Glu Glu 
        115     


<210>  2552
<211>  138
<212>  PRT
<213>  Homo Sapiens

<400>  2552

Met Glu Pro Ala Ala Gly Ser Ser Met Glu Pro Ser Ala Asp Trp Leu 
1               5                   10                  15      


Ala Thr Ala Ala Ala Arg Gly Arg Val Glu Glu Val Arg Ala Leu Leu 
            20                  25                  30          


Glu Ala Gly Ala Leu Pro Asn Ala Pro Asn Ser Tyr Gly Arg Arg Pro 
        35                  40                  45              


Ile Gln Val Met Met Met Gly Ser Ala Arg Val Ala Glu Leu Leu Leu 
    50                  55                  60                  


Leu His Gly Ala Glu Pro Asn Cys Ala Asp Pro Ala Thr Leu Thr Arg 
65                  70                  75                  80  


Pro Val His Asp Ala Ala Arg Glu Gly Phe Leu Asp Thr Leu Val Val 
                85                  90                  95      


Leu His Arg Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp Gly Arg 
            100                 105                 110         


Leu Pro Val Asp Leu Ala Glu Glu Leu Gly His Arg Asp Val Ala Arg 
        115                 120                 125             


His Pro Arg Leu Lys Glu Pro Glu Arg Leu 
    130                 135             


<210>  2553
<211>  156
<212>  PRT
<213>  Homo Sapiens

<400>  2553

Met Glu Pro Ala Ala Gly Ser Ser Met Glu Pro Ser Ala Asp Trp Leu 
1               5                   10                  15      


Ala Thr Ala Ala Ala Arg Gly Arg Val Glu Glu Val Arg Ala Leu Leu 
            20                  25                  30          


Glu Ala Gly Ala Leu Pro Asn Ala Pro Asn Ser Tyr Gly Arg Arg Pro 
        35                  40                  45              


Ile Gln Val Met Met Met Gly Ser Ala Arg Val Ala Glu Leu Leu Leu 
    50                  55                  60                  


Leu His Gly Ala Glu Pro Asn Cys Ala Asp Pro Ala Thr Leu Thr Arg 
65                  70                  75                  80  


Pro Val His Asp Ala Ala Arg Glu Gly Phe Leu Asp Thr Leu Val Val 
                85                  90                  95      


Leu His Arg Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp Gly Arg 
            100                 105                 110         


Leu Pro Val Asp Leu Ala Glu Glu Leu Gly His Arg Asp Val Ala Arg 
        115                 120                 125             


Tyr Leu Arg Ala Ala Ala Gly Gly Thr Arg Gly Ser Asn His Ala Arg 
    130                 135                 140                 


Ile Asp Ala Ala Glu Gly Pro Ser Asp Ile Pro Asp 
145                 150                 155     


<210>  2554
<211>  167
<212>  PRT
<213>  Homo Sapiens

<400>  2554

Met Glu Pro Ala Ala Gly Ser Ser Met Glu Pro Ser Ala Asp Trp Leu 
1               5                   10                  15      


Ala Thr Ala Ala Ala Arg Gly Arg Val Glu Glu Val Arg Ala Leu Leu 
            20                  25                  30          


Glu Ala Gly Ala Leu Pro Asn Ala Pro Asn Ser Tyr Gly Arg Arg Pro 
        35                  40                  45              


Ile Gln Val Met Met Met Gly Ser Ala Arg Val Ala Glu Leu Leu Leu 
    50                  55                  60                  


Leu His Gly Ala Glu Pro Asn Cys Ala Asp Pro Ala Thr Leu Thr Arg 
65                  70                  75                  80  


Pro Val His Asp Ala Ala Arg Glu Gly Phe Leu Asp Thr Leu Val Val 
                85                  90                  95      


Leu His Arg Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp Gly Arg 
            100                 105                 110         


Leu Pro Val Asp Leu Ala Glu Glu Leu Gly His Arg Asp Val Ala Arg 
        115                 120                 125             


Tyr Leu Arg Ala Ala Ala Gly Gly Thr Arg Gly Ser Asn His Ala Arg 
    130                 135                 140                 


Ile Asp Ala Ala Glu Gly Pro Ser Glu Met Ile Gly Asn His Leu Trp 
145                 150                 155                 160 


Val Cys Arg Ser Arg His Ala 
                165         


<210>  2555
<211>  105
<212>  PRT
<213>  Homo Sapiens

<400>  2555

Met Met Met Gly Ser Ala Arg Val Ala Glu Leu Leu Leu Leu His Gly 
1               5                   10                  15      


Ala Glu Pro Asn Cys Ala Asp Pro Ala Thr Leu Thr Arg Pro Val His 
            20                  25                  30          


Asp Ala Ala Arg Glu Gly Phe Leu Asp Thr Leu Val Val Leu His Arg 
        35                  40                  45              


Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp Gly Arg Leu Pro Val 
    50                  55                  60                  


Asp Leu Ala Glu Glu Leu Gly His Arg Asp Val Ala Arg Tyr Leu Arg 
65                  70                  75                  80  


Ala Ala Ala Gly Gly Thr Arg Gly Ser Asn His Ala Arg Ile Asp Ala 
                85                  90                  95      


Ala Glu Gly Pro Ser Asp Ile Pro Asp 
            100                 105 


<210>  2556
<211>  105
<212>  PRT
<213>  Homo Sapiens

<400>  2556

Met Met Met Gly Ser Ala Arg Val Ala Glu Leu Leu Leu Leu His Gly 
1               5                   10                  15      


Ala Glu Pro Asn Cys Ala Asp Pro Ala Thr Leu Thr Arg Pro Val His 
            20                  25                  30          


Asp Ala Ala Arg Glu Gly Phe Leu Asp Thr Leu Val Val Leu His Arg 
        35                  40                  45              


Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp Gly Arg Leu Pro Val 
    50                  55                  60                  


Asp Leu Ala Glu Glu Leu Gly His Arg Asp Val Ala Arg Tyr Leu Arg 
65                  70                  75                  80  


Ala Ala Ala Gly Gly Thr Arg Gly Ser Asn His Ala Arg Ile Asp Ala 
                85                  90                  95      


Ala Glu Gly Pro Ser Asp Ile Pro Asp 
            100                 105 


<210>  2557
<211>  105
<212>  PRT
<213>  Homo Sapiens

<400>  2557

Met Met Met Gly Ser Ala Arg Val Ala Glu Leu Leu Leu Leu His Gly 
1               5                   10                  15      


Ala Glu Pro Asn Cys Ala Asp Pro Ala Thr Leu Thr Arg Pro Val His 
            20                  25                  30          


Asp Ala Ala Arg Glu Gly Phe Leu Asp Thr Leu Val Val Leu His Arg 
        35                  40                  45              


Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp Gly Arg Leu Pro Val 
    50                  55                  60                  


Asp Leu Ala Glu Glu Leu Gly His Arg Asp Val Ala Arg Tyr Leu Arg 
65                  70                  75                  80  


Ala Ala Ala Gly Gly Thr Arg Gly Ser Asn His Ala Arg Ile Asp Ala 
                85                  90                  95      


Ala Glu Gly Pro Ser Asp Ile Pro Asp 
            100                 105 


<210>  2558
<211>  104
<212>  PRT
<213>  Homo Sapiens

<400>  2558

Met Met Met Gly Ser Ala Arg Val Ala Glu Leu Leu Leu Leu His Gly 
1               5                   10                  15      


Ala Glu Pro Asn Cys Ala Asp Pro Ala Thr Leu Thr Arg Pro Val His 
            20                  25                  30          


Asp Ala Ala Arg Glu Gly Phe Leu Asp Thr Leu Val Val Leu His Arg 
        35                  40                  45              


Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp Gly Arg Leu Pro Val 
    50                  55                  60                  


Asp Leu Ala Glu Glu Leu Gly His Arg Asp Val Ala Arg Tyr Leu Arg 
65                  70                  75                  80  


Ala Ala Ala Gly Gly Thr Arg Gly Ser Asn His Ala Arg Ile Asp Ala 
                85                  90                  95      


Ala Glu Gly Pro Ser Gly Glu Asp 
            100                 


<210>  2559
<211>  121
<212>  PRT
<213>  Homo Sapiens

<400>  2559

Met Met Met Gly Ser Ala Arg Val Ala Glu Leu Leu Leu Leu His Gly 
1               5                   10                  15      


Ala Glu Pro Asn Cys Ala Asp Pro Ala Thr Leu Thr Arg Pro Val His 
            20                  25                  30          


Asp Ala Ala Arg Glu Gly Phe Leu Asp Thr Leu Val Val Leu His Arg 
        35                  40                  45              


Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp Gly Arg Leu Pro Val 
    50                  55                  60                  


Asp Leu Ala Glu Glu Leu Gly His Arg Asp Val Ala Arg Tyr Leu Arg 
65                  70                  75                  80  


Ala Ala Ala Gly Gly Thr Arg Gly Ser Asn His Ala Arg Ile Asp Ala 
                85                  90                  95      


Ala Glu Gly Pro Ser Val Thr Ala Ser Ile Gln Val Pro Gly Gly Glu 
            100                 105                 110         


Glu Gly Asp Phe Gly Ser Ser Tyr Ser 
        115                 120     


<210>  2560
<211>  132
<212>  PRT
<213>  Homo Sapiens

<400>  2560

Met Val Arg Arg Phe Leu Val Thr Leu Arg Ile Arg Arg Ala Cys Gly 
1               5                   10                  15      


Pro Pro Arg Val Arg Val Phe Val Val His Ile Pro Arg Leu Thr Gly 
            20                  25                  30          


Glu Trp Ala Ala Pro Gly Ala Pro Ala Ala Val Ala Leu Val Leu Met 
        35                  40                  45              


Leu Leu Arg Ser Gln Arg Leu Gly Gln Gln Pro Leu Pro Arg Arg Pro 
    50                  55                  60                  


Gly His Asp Asp Gly Gln Arg Pro Ser Gly Gly Ala Ala Ala Ala Pro 
65                  70                  75                  80  


Arg Arg Gly Ala Gln Leu Arg Arg Pro Arg His Ser His Pro Thr Arg 
                85                  90                  95      


Ala Arg Arg Cys Pro Gly Gly Leu Pro Gly His Ala Gly Gly Ala Ala 
            100                 105                 110         


Pro Gly Arg Gly Ala Ala Gly Arg Ala Arg Cys Leu Gly Pro Ser Ala 
        115                 120                 125             


Arg Gly Pro Gly 
    130         


<210>  2561
<211>  132
<212>  PRT
<213>  Homo Sapiens

<400>  2561

Met Val Arg Arg Phe Leu Val Thr Leu Arg Ile Arg Arg Ala Cys Gly 
1               5                   10                  15      


Pro Pro Arg Val Arg Val Phe Val Val His Ile Pro Arg Leu Thr Gly 
            20                  25                  30          


Glu Trp Ala Ala Pro Gly Ala Pro Ala Ala Val Ala Leu Val Leu Met 
        35                  40                  45              


Leu Leu Arg Ser Gln Arg Leu Gly Gln Gln Pro Leu Pro Arg Arg Pro 
    50                  55                  60                  


Gly His Asp Asp Gly Gln Arg Pro Ser Gly Gly Ala Ala Ala Ala Pro 
65                  70                  75                  80  


Arg Arg Gly Ala Gln Leu Arg Arg Pro Arg His Ser His Pro Thr Arg 
                85                  90                  95      


Ala Arg Arg Cys Pro Gly Gly Leu Pro Gly His Ala Gly Gly Ala Ala 
            100                 105                 110         


Pro Gly Arg Gly Ala Ala Gly Arg Ala Arg Cys Leu Gly Pro Ser Ala 
        115                 120                 125             


Arg Gly Pro Gly 
    130         


<210>  2562
<211>  85
<212>  PRT
<213>  Homo Sapiens

<400>  2562

Met Ser Val His Met Pro Ala Met Lys Ile Cys Glu Lys Leu Lys Lys 
1               5                   10                  15      


Leu Asp Ser Gln Ile Cys Glu Leu Lys Tyr Glu Lys Thr Leu Asp Leu 
            20                  25                  30          


Ala Ser Val Asp Leu Arg Lys Met Arg Val Ala Glu Leu Lys Gln Ile 
        35                  40                  45              


Leu His Ser Trp Gly Glu Glu Cys Arg Ala Cys Ala Glu Lys Thr Asp 
    50                  55                  60                  


Tyr Val Asn Leu Ile Gln Glu Leu Ala Pro Lys Tyr Ala Ala Thr His 
65                  70                  75                  80  


Pro Lys Thr Glu Leu 
                85  


<210>  2563
<211>  187
<212>  PRT
<213>  Homo Sapiens

<400>  2563

Met Trp Cys Ala Ser Pro Val Ala Val Val Ala Phe Cys Ala Gly Leu 
1               5                   10                  15      


Leu Val Ser His Pro Val Leu Thr Gln Gly Gln Glu Ala Gly Gly Arg 
            20                  25                  30          


Pro Gly Ala Asp Cys Glu Val Cys Lys Glu Phe Leu Asn Arg Phe Tyr 
        35                  40                  45              


Lys Ser Leu Ile Asp Arg Gly Val Asn Phe Ser Leu Asp Thr Ile Glu 
    50                  55                  60                  


Lys Glu Leu Ile Ser Phe Cys Leu Asp Thr Lys Gly Lys Glu Asn Arg 
65                  70                  75                  80  


Leu Cys Tyr Tyr Leu Gly Ala Thr Lys Asp Ala Ala Thr Lys Ile Leu 
                85                  90                  95      


Ser Glu Val Thr Arg Pro Met Ser Val His Met Pro Ala Met Lys Ile 
            100                 105                 110         


Cys Glu Lys Leu Lys Lys Leu Asp Ser Gln Ile Cys Glu Leu Lys Tyr 
        115                 120                 125             


Glu Lys Thr Leu Asp Leu Ala Ser Val Asp Leu Arg Lys Met Arg Val 
    130                 135                 140                 


Ala Glu Leu Lys Gln Ile Leu His Ser Trp Gly Glu Glu Cys Arg Ala 
145                 150                 155                 160 


Cys Ala Glu Lys Thr Asp Tyr Val Asn Leu Ile Gln Glu Leu Ala Pro 
                165                 170                 175     


Lys Tyr Ala Ala Thr His Pro Lys Thr Glu Leu 
            180                 185         


<210>  2564
<211>  111
<212>  PRT
<213>  Homo Sapiens

<400>  2564

Met His Pro Asp Leu Gly Pro Leu Cys Thr Leu Leu Tyr Val Thr Leu 
1               5                   10                  15      


Thr Ile Leu Cys Ser Ser Val Ser Ser Asp Leu Ala Pro Tyr Phe Thr 
            20                  25                  30          


Ser Glu Pro Leu Ser Ala Val Gln Lys Leu Gly Gly Pro Val Val Leu 
        35                  40                  45              


His Cys Ser Ala Gln Pro Val Thr Thr Arg Ile Ser Trp Leu His Asn 
    50                  55                  60                  


Gly Lys Thr Leu Asp Gly Asn Leu Glu His Val Lys Ile His Gln Gly 
65                  70                  75                  80  


Thr Leu Thr Ile Leu Ser Leu Asn Ser Ser Leu Leu Gly Tyr Tyr Gln 
                85                  90                  95      


Cys Leu Ala Asn Asn Ser Ile Gly Ala Ile Val Ser Gly Pro Ala 
            100                 105                 110     


<210>  2565
<211>  143
<212>  PRT
<213>  Homo Sapiens

<400>  2565

Met His Pro Asp Leu Gly Pro Leu Cys Thr Leu Leu Tyr Val Thr Leu 
1               5                   10                  15      


Thr Ile Leu Cys Ser Ser Val Ser Ser Asp Leu Ala Pro Tyr Phe Thr 
            20                  25                  30          


Ser Glu Pro Leu Ser Ala Val Gln Lys Leu Gly Gly Pro Val Val Leu 
        35                  40                  45              


His Cys Ser Ala Gln Pro Val Thr Thr Arg Ile Ser Trp Leu His Asn 
    50                  55                  60                  


Gly Lys Thr Leu Asp Gly Asn Leu Glu His Val Lys Ile His Gln Gly 
65                  70                  75                  80  


Thr Leu Thr Ile Leu Ser Leu Asn Ser Ser Leu Leu Gly Tyr Tyr Gln 
                85                  90                  95      


Cys Leu Ala Asn Asn Ser Ile Gly Ala Ile Val Ser Gly Pro Ala Thr 
            100                 105                 110         


Val Ser Val Ala Val Leu Gly Asp Phe Gly Ser Ser Thr Lys His Val 
        115                 120                 125             


Ile Thr Ala Glu Glu Lys Ser Ala Gly Phe Ile Gly Cys Arg Val 
    130                 135                 140             


<210>  2566
<211>  165
<212>  PRT
<213>  Homo Sapiens

<400>  2566

Met His Pro Asp Leu Gly Pro Leu Cys Thr Leu Leu Tyr Val Thr Leu 
1               5                   10                  15      


Thr Ile Leu Cys Ser Ser Val Ser Ser Asp Leu Ala Pro Tyr Phe Thr 
            20                  25                  30          


Ser Glu Pro Leu Ser Ala Val Gln Lys Leu Gly Gly Pro Val Val Leu 
        35                  40                  45              


His Cys Ser Ala Gln Pro Val Thr Thr Arg Ile Ser Trp Leu His Asn 
    50                  55                  60                  


Gly Lys Thr Leu Asp Gly Asn Leu Glu His Val Lys Ile His Gln Gly 
65                  70                  75                  80  


Thr Leu Thr Ile Leu Ser Leu Asn Ser Ser Leu Leu Gly Tyr Tyr Gln 
                85                  90                  95      


Cys Leu Ala Asn Asn Ser Ile Gly Ala Ile Val Ser Gly Pro Ala Thr 
            100                 105                 110         


Val Ser Val Ala Val Leu Gly Asp Phe Gly Ser Ser Thr Lys His Val 
        115                 120                 125             


Ile Thr Ala Glu Glu Lys Ser Ala Gly Phe Ile Gly Cys Arg Val Pro 
    130                 135                 140                 


Glu Ser Asn Pro Lys Ala Glu Val Arg Tyr Lys Ile Arg Gly Lys Trp 
145                 150                 155                 160 


Leu Glu His Ser Thr 
                165 


<210>  2567
<211>  1264
<212>  PRT
<213>  Homo Sapiens

<400>  2567

Met His Pro Asp Leu Gly Pro Leu Cys Thr Leu Leu Tyr Val Thr Leu 
1               5                   10                  15      


Thr Ile Leu Cys Ser Ser Val Ser Ser Asp Leu Ala Pro Tyr Phe Thr 
            20                  25                  30          


Ser Glu Pro Leu Ser Ala Val Gln Lys Leu Gly Gly Pro Val Val Leu 
        35                  40                  45              


His Cys Ser Ala Gln Pro Val Thr Thr Arg Ile Ser Trp Leu His Asn 
    50                  55                  60                  


Gly Lys Thr Leu Asp Gly Asn Leu Glu His Val Lys Ile His Gln Gly 
65                  70                  75                  80  


Thr Leu Thr Ile Leu Ser Leu Asn Ser Ser Leu Leu Gly Tyr Tyr Gln 
                85                  90                  95      


Cys Leu Ala Asn Asn Ser Ile Gly Ala Ile Val Ser Gly Pro Ala Thr 
            100                 105                 110         


Val Ser Val Ala Val Leu Gly Asp Phe Gly Ser Ser Thr Lys His Val 
        115                 120                 125             


Ile Thr Ala Glu Glu Lys Ser Ala Gly Phe Ile Gly Cys Arg Val Pro 
    130                 135                 140                 


Glu Ser Asn Pro Lys Ala Glu Val Arg Tyr Lys Ile Arg Gly Lys Trp 
145                 150                 155                 160 


Leu Glu His Ser Thr Glu Asn Tyr Leu Ile Leu Pro Ser Gly Asn Leu 
                165                 170                 175     


Gln Ile Leu Asn Val Ser Leu Glu Asp Lys Gly Ser Tyr Lys Cys Ala 
            180                 185                 190         


Ala Tyr Asn Pro Val Thr His Gln Leu Lys Val Glu Pro Ile Gly Arg 
        195                 200                 205             


Lys Leu Leu Val Ser Arg Pro Ser Ser Asp Asp Val His Ile Leu His 
    210                 215                 220                 


Pro Thr His Ser Gln Ala Leu Ala Val Leu Ser Arg Ser Pro Val Thr 
225                 230                 235                 240 


Leu Glu Cys Val Val Ser Gly Val Pro Ala Pro Gln Val Tyr Trp Leu 
                245                 250                 255     


Lys Asp Gly Gln Asp Ile Ala Pro Gly Ser Asn Trp Arg Arg Leu Tyr 
            260                 265                 270         


Ser His Leu Ala Thr Asp Ser Val Asp Pro Ala Asp Ser Gly Asn Tyr 
        275                 280                 285             


Ser Cys Met Ala Gly Asn Lys Ser Gly Asp Val Lys Tyr Val Thr Tyr 
    290                 295                 300                 


Met Val Asn Val Leu Glu His Ala Ser Ile Ser Lys Gly Leu Gln Asp 
305                 310                 315                 320 


Gln Ile Val Ser Leu Gly Ala Thr Val His Phe Thr Cys Asp Val His 
                325                 330                 335     


Gly Asn Pro Ala Pro Asn Cys Thr Trp Phe His Asn Ala Gln Pro Ile 
            340                 345                 350         


His Pro Ser Ala Arg His Leu Thr Ala Gly Asn Gly Leu Lys Ile Ser 
        355                 360                 365             


Gly Val Thr Val Glu Asp Val Gly Met Tyr Gln Cys Val Ala Asp Asn 
    370                 375                 380                 


Gly Ile Gly Phe Met His Ser Thr Gly Arg Leu Glu Ile Glu Asn Asp 
385                 390                 395                 400 


Gly Gly Phe Lys Pro Val Ile Ile Thr Ala Pro Val Ser Ala Lys Val 
                405                 410                 415     


Ala Asp Gly Asp Phe Val Thr Leu Ser Cys Asn Ala Ser Gly Leu Pro 
            420                 425                 430         


Val Pro Val Ile Arg Trp Tyr Asp Ser His Gly Leu Ile Thr Ser His 
        435                 440                 445             


Pro Ser Gln Val Leu Arg Ser Lys Ser Arg Lys Ser Gln Leu Ser Arg 
    450                 455                 460                 


Pro Glu Gly Leu Asn Leu Glu Pro Val Tyr Phe Val Leu Ser Gln Ala 
465                 470                 475                 480 


Gly Ala Ser Ser Leu His Ile Gln Ala Val Thr Gln Glu His Ala Gly 
                485                 490                 495     


Lys Tyr Ile Cys Glu Ala Ala Asn Glu His Gly Thr Thr Gln Ala Glu 
            500                 505                 510         


Ala Ser Leu Met Val Val Pro Phe Glu Thr Asn Thr Lys Ala Glu Thr 
        515                 520                 525             


Val Thr Leu Pro Asp Ala Ala Gln Asn Asp Asp Arg Ser Lys Arg Asp 
    530                 535                 540                 


Gly Ser Glu Thr Gly Leu Leu Ser Ser Phe Pro Val Lys Val His Pro 
545                 550                 555                 560 


Ser Ala Val Glu Ser Ala Pro Glu Lys Asn Ala Ser Gly Ile Ser Val 
                565                 570                 575     


Pro Asp Ala Pro Ile Ile Leu Ser Pro Pro Gln Thr His Thr Pro Asp 
            580                 585                 590         


Thr Tyr Asn Leu Val Trp Arg Ala Gly Lys Asp Gly Gly Leu Pro Ile 
        595                 600                 605             


Asn Ala Tyr Phe Val Lys Tyr Arg Lys Leu Asp Asp Gly Val Gly Met 
    610                 615                 620                 


Leu Gly Ser Trp His Thr Val Arg Val Pro Gly Ser Glu Asn Glu Leu 
625                 630                 635                 640 


His Leu Ala Glu Leu Glu Pro Ser Ser Leu Tyr Glu Val Leu Met Val 
                645                 650                 655     


Ala Arg Ser Ala Ala Gly Glu Gly Gln Pro Ala Met Leu Thr Phe Arg 
            660                 665                 670         


Thr Ser Lys Glu Lys Thr Ala Ser Ser Lys Asn Thr Gln Ala Ser Ser 
        675                 680                 685             


Pro Pro Val Gly Ile Pro Lys Tyr Pro Val Val Ser Glu Ala Ala Asn 
    690                 695                 700                 


Asn Asn Phe Gly Val Val Leu Thr Asp Ser Ser Arg His Ser Gly Val 
705                 710                 715                 720 


Pro Glu Ala Pro Asp Arg Pro Thr Ile Ser Thr Ala Ser Glu Thr Ser 
                725                 730                 735     


Val Tyr Val Thr Trp Ile Pro Arg Ala Asn Gly Gly Ser Pro Ile Thr 
            740                 745                 750         


Ala Phe Lys Val Glu Tyr Lys Arg Met Arg Thr Ser Asn Trp Leu Val 
        755                 760                 765             


Ala Ala Glu Asp Ile Pro Pro Ser Lys Leu Ser Val Glu Val Arg Ser 
    770                 775                 780                 


Leu Glu Pro Gly Ser Thr Tyr Lys Phe Arg Val Ile Ala Ile Asn His 
785                 790                 795                 800 


Tyr Gly Glu Ser Phe Arg Ser Ser Ala Ser Arg Pro Tyr Gln Val Val 
                805                 810                 815     


Gly Phe Pro Asn Arg Phe Ser Ser Arg Pro Ile Thr Gly Pro His Ile 
            820                 825                 830         


Ala Tyr Thr Glu Ala Val Ser Asp Thr Gln Ile Met Leu Lys Trp Thr 
        835                 840                 845             


Tyr Ile Pro Ser Ser Asn Asn Asn Thr Pro Ile Gln Gly Phe Tyr Ile 
    850                 855                 860                 


Tyr Tyr Arg Pro Thr Asp Ser Asp Asn Asp Ser Asp Tyr Lys Arg Asp 
865                 870                 875                 880 


Val Val Glu Gly Ser Lys Gln Trp His Met Ile Gly His Leu Gln Pro 
                885                 890                 895     


Glu Thr Ser Tyr Asp Ile Lys Met Gln Cys Phe Asn Glu Gly Gly Glu 
            900                 905                 910         


Ser Glu Phe Ser Asn Val Met Ile Cys Glu Thr Lys Val Lys Arg Val 
        915                 920                 925             


Pro Gly Ala Ser Glu Tyr Pro Val Lys Asp Leu Ser Thr Pro Pro Asn 
    930                 935                 940                 


Ser Leu Gly Ser Gly Gly Asn Val Gly Pro Ala Thr Ser Pro Ala Arg 
945                 950                 955                 960 


Ser Ser Asp Met Leu Tyr Leu Ile Val Gly Cys Val Leu Gly Val Met 
                965                 970                 975     


Val Leu Ile Leu Met Val Phe Ile Ala Met Cys Leu Trp Lys Asn Arg 
            980                 985                 990         


Gln Gln Asn Thr Ile Gln Lys Tyr  Asp Pro Pro Gly Tyr  Leu Tyr Gln 
        995                 1000                 1005             


Gly Ser  Asp Met Asn Gly Gln  Met Val Asp Tyr Thr  Thr Leu Ser 
    1010                 1015                 1020             


Gly Ala  Ser Gln Ile Asn Gly  Asn Val His Gly Gly  Phe Leu Thr 
    1025                 1030                 1035             


Asn Gly  Gly Leu Ser Ser Gly  Tyr Ser His Leu His  His Lys Val 
    1040                 1045                 1050             


Pro Asn  Ala Val Asn Gly Ile  Val Asn Gly Ser Leu  Asn Gly Gly 
    1055                 1060                 1065             


Leu Tyr  Ser Gly His Ser Asn  Ser Leu Thr Arg Thr  His Val Asp 
    1070                 1075                 1080             


Phe Glu  His Pro His His Leu  Val Asn Gly Gly Gly  Met Tyr Thr 
    1085                 1090                 1095             


Ala Val  Pro Gln Ile Asp Pro  Leu Glu Cys Val Asn  Cys Arg Asn 
    1100                 1105                 1110             


Cys Arg  Asn Asn Asn Arg Cys  Phe Thr Lys Thr Asn  Ser Thr Phe 
    1115                 1120                 1125             


Ser Ser  Ser Pro Pro Pro Val  Val Pro Val Val Ala  Pro Tyr Pro 
    1130                 1135                 1140             


Gln Asp  Gly Leu Glu Met Lys  Pro Leu Ser His Val  Lys Val Pro 
    1145                 1150                 1155             


Val Cys  Leu Thr Ser Ala Val  Pro Asp Cys Gly Gln  Leu Pro Glu 
    1160                 1165                 1170             


Glu Ser  Val Lys Asp Asn Val  Glu Pro Val Pro Thr  Gln Arg Thr 
    1175                 1180                 1185             


Cys Cys  Gln Asp Ile Val Asn  Asp Val Ser Ser Asp  Gly Ser Glu 
    1190                 1195                 1200             


Asp Pro  Ala Glu Phe Ser Arg  Gly Asp Ser Cys Ala  His Ser Glu 
    1205                 1210                 1215             


Thr Glu  Ile Asn Ile Val Ser  Trp Asn Ala Leu Ile  Leu Pro Pro 
    1220                 1225                 1230             


Val Pro  Glu Gly Cys Ala Glu  Lys Thr Met Trp Ser  Pro Pro Gly 
    1235                 1240                 1245             


Ile Pro  Leu Asp Ser Pro Thr  Glu Val Leu Gln Gln  Pro Arg Glu 
    1250                 1255                 1260             


Thr 
    


<210>  2568
<211>  1287
<212>  PRT
<213>  Homo Sapiens

<400>  2568

Met His Pro Asp Leu Gly Pro Leu Cys Thr Leu Leu Tyr Val Thr Leu 
1               5                   10                  15      


Thr Ile Leu Cys Ser Ser Val Ser Ser Asp Leu Ala Pro Tyr Phe Thr 
            20                  25                  30          


Ser Glu Pro Leu Ser Ala Val Gln Lys Leu Gly Gly Pro Val Val Leu 
        35                  40                  45              


His Cys Ser Ala Gln Pro Val Thr Thr Arg Ile Ser Trp Leu His Asn 
    50                  55                  60                  


Gly Lys Thr Leu Asp Gly Asn Leu Glu His Val Lys Ile His Gln Gly 
65                  70                  75                  80  


Thr Leu Thr Ile Leu Ser Leu Asn Ser Ser Leu Leu Gly Tyr Tyr Gln 
                85                  90                  95      


Cys Leu Ala Asn Asn Ser Ile Gly Ala Ile Val Ser Gly Pro Ala Thr 
            100                 105                 110         


Val Ser Val Ala Val Leu Gly Asp Phe Gly Ser Ser Thr Lys His Val 
        115                 120                 125             


Ile Thr Ala Glu Glu Lys Ser Ala Gly Phe Ile Gly Cys Arg Val Pro 
    130                 135                 140                 


Glu Ser Asn Pro Lys Ala Glu Val Arg Tyr Lys Ile Arg Gly Lys Trp 
145                 150                 155                 160 


Leu Glu His Ser Thr Glu Asn Tyr Leu Ile Leu Pro Ser Gly Asn Leu 
                165                 170                 175     


Gln Ile Leu Asn Val Ser Leu Glu Asp Lys Gly Ser Tyr Lys Cys Ala 
            180                 185                 190         


Ala Tyr Asn Pro Val Thr His Gln Leu Lys Val Glu Pro Ile Gly Arg 
        195                 200                 205             


Lys Leu Leu Val Ser Arg Pro Ser Ser Asp Asp Val His Ile Leu His 
    210                 215                 220                 


Pro Thr His Ser Gln Ala Leu Ala Val Leu Ser Arg Ser Pro Val Thr 
225                 230                 235                 240 


Leu Glu Cys Val Val Ser Gly Val Pro Ala Pro Gln Val Tyr Trp Leu 
                245                 250                 255     


Lys Asp Gly Gln Asp Ile Ala Pro Gly Ser Asn Trp Arg Arg Leu Tyr 
            260                 265                 270         


Ser His Leu Ala Thr Asp Ser Val Asp Pro Ala Asp Ser Gly Asn Tyr 
        275                 280                 285             


Ser Cys Met Ala Gly Asn Lys Ser Gly Asp Val Lys Tyr Val Thr Tyr 
    290                 295                 300                 


Met Val Asn Val Leu Glu His Ala Ser Ile Ser Lys Gly Leu Gln Asp 
305                 310                 315                 320 


Gln Ile Val Ser Leu Gly Ala Thr Val His Phe Thr Cys Asp Val His 
                325                 330                 335     


Gly Asn Pro Ala Pro Asn Cys Thr Trp Phe His Asn Ala Gln Pro Ile 
            340                 345                 350         


His Pro Ser Ala Arg His Leu Thr Ala Gly Asn Gly Leu Lys Ile Ser 
        355                 360                 365             


Gly Val Thr Val Glu Asp Val Gly Met Tyr Gln Cys Val Ala Asp Asn 
    370                 375                 380                 


Gly Ile Gly Phe Met His Ser Thr Gly Arg Leu Glu Ile Glu Asn Asp 
385                 390                 395                 400 


Gly Gly Phe Lys Pro Val Ile Ile Thr Ala Pro Val Ser Ala Lys Val 
                405                 410                 415     


Ala Asp Gly Asp Phe Val Thr Leu Ser Cys Asn Ala Ser Gly Leu Pro 
            420                 425                 430         


Val Pro Val Ile Arg Trp Tyr Asp Ser His Gly Leu Ile Thr Ser His 
        435                 440                 445             


Pro Ser Gln Val Leu Arg Ser Lys Ser Arg Lys Ser Gln Leu Ser Arg 
    450                 455                 460                 


Pro Glu Gly Leu Asn Leu Glu Pro Val Tyr Phe Val Leu Ser Gln Ala 
465                 470                 475                 480 


Gly Ala Ser Ser Leu His Ile Gln Ala Val Thr Gln Glu His Ala Gly 
                485                 490                 495     


Lys Tyr Ile Cys Glu Ala Ala Asn Glu His Gly Thr Thr Gln Ala Glu 
            500                 505                 510         


Ala Ser Leu Met Val Val Pro Phe Glu Thr Asn Thr Lys Ala Glu Thr 
        515                 520                 525             


Val Thr Leu Pro Asp Ala Ala Gln Asn Asp Asp Arg Ser Lys Arg Asp 
    530                 535                 540                 


Gly Ser Glu Thr Gly Leu Leu Ser Ser Phe Pro Val Lys Val His Pro 
545                 550                 555                 560 


Ser Ala Val Glu Ser Ala Pro Glu Lys Asn Ala Ser Gly Ile Ser Val 
                565                 570                 575     


Pro Asp Ala Pro Ile Ile Leu Ser Pro Pro Gln Thr His Thr Pro Asp 
            580                 585                 590         


Thr Tyr Asn Leu Val Trp Arg Ala Gly Lys Asp Gly Gly Leu Pro Ile 
        595                 600                 605             


Asn Ala Tyr Phe Val Lys Tyr Arg Lys Leu Asp Asp Gly Val Gly Met 
    610                 615                 620                 


Leu Gly Ser Trp His Thr Val Arg Val Pro Gly Ser Glu Asn Glu Leu 
625                 630                 635                 640 


His Leu Ala Glu Leu Glu Pro Ser Ser Leu Tyr Glu Val Leu Met Val 
                645                 650                 655     


Ala Arg Ser Ala Ala Gly Glu Gly Gln Pro Ala Met Leu Thr Phe Arg 
            660                 665                 670         


Thr Ser Lys Glu Lys Thr Ala Ser Ser Lys Asn Thr Gln Ala Ser Ser 
        675                 680                 685             


Pro Pro Val Gly Ile Pro Lys Tyr Pro Val Val Ser Glu Ala Ala Asn 
    690                 695                 700                 


Asn Asn Phe Gly Val Val Leu Thr Asp Ser Ser Arg His Ser Gly Val 
705                 710                 715                 720 


Pro Glu Ala Pro Asp Arg Pro Thr Ile Ser Thr Ala Ser Glu Thr Ser 
                725                 730                 735     


Val Tyr Val Thr Trp Ile Pro Arg Ala Asn Gly Gly Ser Pro Ile Thr 
            740                 745                 750         


Ala Phe Lys Val Glu Tyr Lys Arg Met Arg Thr Ser Asn Trp Leu Val 
        755                 760                 765             


Ala Ala Glu Asp Ile Pro Pro Ser Lys Leu Ser Val Glu Val Arg Ser 
    770                 775                 780                 


Leu Glu Pro Gly Ser Thr Tyr Lys Phe Arg Val Ile Ala Ile Asn His 
785                 790                 795                 800 


Tyr Gly Glu Ser Phe Arg Ser Ser Ala Ser Arg Pro Tyr Gln Val Val 
                805                 810                 815     


Gly Phe Pro Asn Arg Phe Ser Ser Arg Pro Ile Thr Gly Pro His Ile 
            820                 825                 830         


Ala Tyr Thr Glu Ala Val Ser Asp Thr Gln Ile Met Leu Lys Trp Thr 
        835                 840                 845             


Tyr Ile Pro Ser Ser Asn Asn Asn Thr Pro Ile Gln Gly Phe Tyr Ile 
    850                 855                 860                 


Tyr Tyr Arg Pro Thr Asp Ser Asp Asn Asp Ser Asp Tyr Lys Arg Asp 
865                 870                 875                 880 


Val Val Glu Gly Ser Lys Gln Trp His Met Ile Gly His Leu Gln Pro 
                885                 890                 895     


Glu Thr Ser Tyr Asp Ile Lys Met Gln Cys Phe Asn Glu Gly Gly Glu 
            900                 905                 910         


Ser Glu Phe Ser Asn Val Met Ile Cys Glu Thr Lys Val Lys Arg Val 
        915                 920                 925             


Pro Gly Ala Ser Glu Tyr Pro Val Lys Asp Leu Ser Thr Pro Pro Asn 
    930                 935                 940                 


Ser Leu Gly Ser Gly Gly Asn Val Gly Pro Ala Thr Ser Pro Ala Arg 
945                 950                 955                 960 


Ser Ser Asp Met Leu Tyr Leu Ile Val Gly Cys Val Leu Gly Val Met 
                965                 970                 975     


Val Leu Ile Leu Met Val Phe Ile Ala Met Cys Leu Trp Lys Asn Arg 
            980                 985                 990         


Gln Gln Asn Thr Ile Gln Lys Tyr  Asp Pro Pro Gly Tyr  Leu Tyr Gln 
        995                 1000                 1005             


Gly Ser  Asp Met Asn Gly Gln  Met Val Asp Tyr Thr  Thr Leu Ser 
    1010                 1015                 1020             


Gly Ala  Ser Gln Ile Asn Gly  Asn Val His Gly Gly  Phe Leu Thr 
    1025                 1030                 1035             


Asn Gly  Gly Leu Ser Ser Gly  Tyr Ser His Leu His  His Lys Val 
    1040                 1045                 1050             


Pro Asn  Ala Val Asn Gly Ile  Val Asn Gly Ser Leu  Asn Gly Gly 
    1055                 1060                 1065             


Leu Tyr  Ser Gly His Ser Asn  Ser Leu Thr Arg Thr  His Val Asp 
    1070                 1075                 1080             


Phe Glu  His Pro His His Leu  Val Asn Gly Gly Gly  Met Tyr Thr 
    1085                 1090                 1095             


Ala Val  Pro Gln Ile Asp Pro  Leu Glu Cys Val Asn  Cys Arg Asn 
    1100                 1105                 1110             


Cys Arg  Asn Asn Asn Arg Cys  Phe Thr Lys Thr Asn  Ser Thr Phe 
    1115                 1120                 1125             


Ser Ser  Ser Pro Pro Pro Val  Val Pro Val Val Ala  Pro Tyr Pro 
    1130                 1135                 1140             


Gln Asp  Gly Leu Glu Met Lys  Pro Leu Ser His Val  Lys Val Pro 
    1145                 1150                 1155             


Val Cys  Leu Thr Ser Ala Val  Pro Asp Cys Gly Gln  Leu Pro Glu 
    1160                 1165                 1170             


Glu Ser  Val Lys Asp Asn Val  Glu Pro Val Pro Thr  Gln Arg Thr 
    1175                 1180                 1185             


Cys Cys  Gln Asp Ile Val Asn  Asp Val Ser Ser Asp  Gly Ser Glu 
    1190                 1195                 1200             


Asp Pro  Ala Glu Phe Ser Arg  Gly Gln Glu Gly Met  Ile Asn Leu 
    1205                 1210                 1215             


Arg Ile  Pro Asp His Leu Gln  Leu Ala Lys Ser Cys  Val Trp Glu 
    1220                 1225                 1230             


Gly Asp  Ser Cys Ala His Ser  Glu Thr Glu Ile Asn  Ile Val Ser 
    1235                 1240                 1245             


Trp Asn  Ala Leu Ile Leu Pro  Pro Val Pro Glu Gly  Cys Ala Glu 
    1250                 1255                 1260             


Lys Thr  Met Trp Ser Pro Pro  Gly Ile Pro Leu Asp  Ser Pro Thr 
    1265                 1270                 1275             


Glu Val  Leu Gln Gln Pro Arg  Glu Thr 
    1280                 1285         


<210>  2569
<211>  641
<212>  PRT
<213>  Homo Sapiens

<400>  2569

Met Leu Gly Ser Trp His Thr Val Arg Val Pro Gly Ser Glu Asn Glu 
1               5                   10                  15      


Leu His Leu Ala Glu Leu Glu Pro Ser Ser Leu Tyr Glu Val Leu Met 
            20                  25                  30          


Val Ala Arg Ser Ala Ala Gly Glu Gly Gln Pro Ala Met Leu Thr Phe 
        35                  40                  45              


Arg Thr Ser Lys Glu Lys Thr Ala Ser Ser Lys Asn Thr Gln Ala Ser 
    50                  55                  60                  


Ser Pro Pro Val Gly Ile Pro Lys Tyr Pro Val Val Ser Glu Ala Ala 
65                  70                  75                  80  


Asn Asn Asn Phe Gly Val Val Leu Thr Asp Ser Ser Arg His Ser Gly 
                85                  90                  95      


Val Pro Glu Ala Pro Asp Arg Pro Thr Ile Ser Thr Ala Ser Glu Thr 
            100                 105                 110         


Ser Val Tyr Val Thr Trp Ile Pro Arg Ala Asn Gly Gly Ser Pro Ile 
        115                 120                 125             


Thr Ala Phe Lys Val Glu Tyr Lys Arg Met Arg Thr Ser Asn Trp Leu 
    130                 135                 140                 


Val Ala Ala Glu Asp Ile Pro Pro Ser Lys Leu Ser Val Glu Val Arg 
145                 150                 155                 160 


Ser Leu Glu Pro Gly Ser Thr Tyr Lys Phe Arg Val Ile Ala Ile Asn 
                165                 170                 175     


His Tyr Gly Glu Ser Phe Arg Ser Ser Ala Ser Arg Pro Tyr Gln Val 
            180                 185                 190         


Val Gly Phe Pro Asn Arg Phe Ser Ser Arg Pro Ile Thr Gly Pro His 
        195                 200                 205             


Ile Ala Tyr Thr Glu Ala Val Ser Asp Thr Gln Ile Met Leu Lys Trp 
    210                 215                 220                 


Thr Tyr Ile Pro Ser Ser Asn Asn Asn Thr Pro Ile Gln Gly Phe Tyr 
225                 230                 235                 240 


Ile Tyr Tyr Arg Pro Thr Asp Ser Asp Asn Asp Ser Asp Tyr Lys Arg 
                245                 250                 255     


Asp Val Val Glu Gly Ser Lys Gln Trp His Met Ile Gly His Leu Gln 
            260                 265                 270         


Pro Glu Thr Ser Tyr Asp Ile Lys Met Gln Cys Phe Asn Glu Gly Gly 
        275                 280                 285             


Glu Ser Glu Phe Ser Asn Val Met Ile Cys Glu Thr Lys Val Lys Arg 
    290                 295                 300                 


Val Pro Gly Ala Ser Glu Tyr Pro Val Lys Asp Leu Ser Thr Pro Pro 
305                 310                 315                 320 


Asn Ser Leu Gly Ser Gly Gly Asn Val Gly Pro Ala Thr Ser Pro Ala 
                325                 330                 335     


Arg Ser Ser Asp Met Leu Tyr Leu Ile Val Gly Cys Val Leu Gly Val 
            340                 345                 350         


Met Val Leu Ile Leu Met Val Phe Ile Ala Met Cys Leu Trp Lys Asn 
        355                 360                 365             


Arg Gln Gln Asn Thr Ile Gln Lys Tyr Asp Pro Pro Gly Tyr Leu Tyr 
    370                 375                 380                 


Gln Gly Ser Asp Met Asn Gly Gln Met Val Asp Tyr Thr Thr Leu Ser 
385                 390                 395                 400 


Gly Ala Ser Gln Ile Asn Gly Asn Val His Gly Gly Phe Leu Thr Asn 
                405                 410                 415     


Gly Gly Leu Ser Ser Gly Tyr Ser His Leu His His Lys Val Pro Asn 
            420                 425                 430         


Ala Val Asn Gly Ile Val Asn Gly Ser Leu Asn Gly Gly Leu Tyr Ser 
        435                 440                 445             


Gly His Ser Asn Ser Leu Thr Arg Thr His Val Asp Phe Glu His Pro 
    450                 455                 460                 


His His Leu Val Asn Gly Gly Gly Met Tyr Thr Ala Val Pro Gln Ile 
465                 470                 475                 480 


Asp Pro Leu Glu Cys Val Asn Cys Arg Asn Cys Arg Asn Asn Asn Arg 
                485                 490                 495     


Cys Phe Thr Lys Thr Asn Ser Thr Phe Ser Ser Ser Pro Pro Pro Val 
            500                 505                 510         


Val Pro Val Val Ala Pro Tyr Pro Gln Asp Gly Leu Glu Met Lys Pro 
        515                 520                 525             


Leu Ser His Val Lys Val Pro Val Cys Leu Thr Ser Ala Val Pro Asp 
    530                 535                 540                 


Cys Gly Gln Leu Pro Glu Glu Ser Val Lys Asp Asn Val Glu Pro Val 
545                 550                 555                 560 


Pro Thr Gln Arg Thr Cys Cys Gln Asp Ile Val Asn Asp Val Ser Ser 
                565                 570                 575     


Asp Gly Ser Glu Asp Pro Ala Glu Phe Ser Arg Gly Asp Ser Cys Ala 
            580                 585                 590         


His Ser Glu Thr Glu Ile Asn Ile Val Ser Trp Asn Ala Leu Ile Leu 
        595                 600                 605             


Pro Pro Val Pro Glu Gly Cys Ala Glu Lys Thr Met Trp Ser Pro Pro 
    610                 615                 620                 


Gly Ile Pro Leu Asp Ser Pro Thr Glu Val Leu Gln Gln Pro Arg Glu 
625                 630                 635                 640 


Thr 
    


<210>  2570
<211>  650
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2570

Xaa Asp Leu Ala Pro Tyr Phe Thr Ser Glu Pro Leu Ser Ala Val Gln 
1               5                   10                  15      


Lys Leu Gly Gly Pro Val Val Leu His Cys Ser Ala Gln Pro Val Thr 
            20                  25                  30          


Thr Arg Ile Ser Trp Leu His Asn Gly Lys Thr Leu Asp Gly Asn Leu 
        35                  40                  45              


Glu His Val Lys Ile His Gln Gly Thr Leu Thr Ile Leu Ser Leu Asn 
    50                  55                  60                  


Ser Ser Leu Leu Gly Tyr Tyr Gln Cys Leu Ala Asn Asn Ser Ile Gly 
65                  70                  75                  80  


Ala Ile Val Ser Gly Pro Ala Thr Val Ser Val Ala Val Leu Gly Asp 
                85                  90                  95      


Phe Gly Ser Ser Thr Lys His Val Ile Thr Ala Glu Glu Lys Ser Ala 
            100                 105                 110         


Gly Phe Ile Gly Cys Arg Val Pro Glu Ser Asn Pro Lys Ala Glu Val 
        115                 120                 125             


Arg Tyr Lys Ile Arg Gly Lys Trp Leu Glu His Ser Thr Glu Asn Tyr 
    130                 135                 140                 


Leu Ile Leu Pro Ser Gly Asn Leu Gln Ile Leu Asn Val Ser Leu Glu 
145                 150                 155                 160 


Asp Lys Gly Ser Tyr Lys Cys Ala Ala Tyr Asn Pro Val Thr His Gln 
                165                 170                 175     


Leu Lys Val Glu Pro Ile Gly Arg Lys Leu Leu Val Ser Arg Pro Ser 
            180                 185                 190         


Ser Asp Asp Val His Ile Leu His Pro Thr His Ser Gln Ala Leu Ala 
        195                 200                 205             


Val Leu Ser Arg Ser Pro Val Thr Leu Glu Cys Val Val Ser Gly Val 
    210                 215                 220                 


Pro Ala Pro Gln Val Tyr Trp Leu Lys Asp Gly Gln Asp Ile Ala Pro 
225                 230                 235                 240 


Gly Ser Asn Trp Arg Arg Leu Tyr Ser His Leu Ala Thr Asp Ser Val 
                245                 250                 255     


Asp Pro Ala Asp Ser Gly Asn Tyr Ser Cys Met Ala Gly Asn Lys Ser 
            260                 265                 270         


Gly Asp Val Lys Tyr Val Thr Tyr Met Val Asn Val Leu Glu His Ala 
        275                 280                 285             


Ser Ile Ser Lys Gly Leu Gln Asp Gln Ile Val Ser Leu Gly Ala Thr 
    290                 295                 300                 


Val His Phe Thr Cys Asp Val His Gly Asn Pro Ala Pro Asn Cys Thr 
305                 310                 315                 320 


Trp Phe His Asn Ala Gln Pro Ile His Pro Ser Ala Arg His Leu Thr 
                325                 330                 335     


Ala Gly Asn Gly Leu Lys Ile Ser Gly Val Thr Val Glu Asp Val Gly 
            340                 345                 350         


Met Tyr Gln Cys Val Ala Asp Asn Gly Ile Gly Phe Met His Ser Thr 
        355                 360                 365             


Gly Arg Leu Glu Ile Glu Asn Asp Gly Gly Phe Lys Pro Val Ile Ile 
    370                 375                 380                 


Thr Ala Pro Val Ser Ala Lys Val Ala Asp Gly Asp Phe Val Thr Leu 
385                 390                 395                 400 


Ser Cys Asn Ala Ser Gly Leu Pro Val Pro Val Ile Arg Trp Tyr Asp 
                405                 410                 415     


Ser His Gly Leu Ile Thr Ser His Pro Ser Gln Val Leu Arg Ser Lys 
            420                 425                 430         


Ser Arg Lys Ser Gln Leu Ser Arg Pro Glu Gly Leu Asn Leu Glu Pro 
        435                 440                 445             


Val Tyr Phe Val Leu Ser Gln Ala Gly Ala Ser Ser Leu His Ile Gln 
    450                 455                 460                 


Ala Val Thr Gln Glu His Ala Gly Lys Tyr Ile Cys Glu Ala Ala Asn 
465                 470                 475                 480 


Glu His Gly Thr Thr Gln Ala Glu Ala Ser Leu Met Val Val Pro Phe 
                485                 490                 495     


Glu Thr Asn Thr Lys Ala Glu Thr Val Thr Leu Pro Asp Ala Ala Gln 
            500                 505                 510         


Asn Asp Asp Arg Ser Lys Arg Asp Gly Ser Glu Thr Gly Leu Leu Ser 
        515                 520                 525             


Ser Phe Pro Val Lys Val His Pro Ser Ala Val Glu Ser Ala Pro Glu 
    530                 535                 540                 


Lys Asn Ala Ser Gly Ile Ser Val Pro Asp Ala Pro Ile Ile Leu Ser 
545                 550                 555                 560 


Pro Pro Gln Thr His Thr Pro Asp Thr Tyr Asn Leu Val Trp Arg Ala 
                565                 570                 575     


Gly Lys Asp Gly Gly Leu Pro Ile Asn Ala Tyr Phe Val Lys Tyr Arg 
            580                 585                 590         


Lys Leu Asp Asp Gly Val Gly Met Leu Gly Ser Trp His Thr Val Arg 
        595                 600                 605             


Val Pro Gly Ser Glu Asn Glu Leu His Leu Ala Glu Leu Glu Pro Ser 
    610                 615                 620                 


Ser Leu Tyr Glu Val Leu Met Val Ala Arg Ser Ala Ala Gly Glu Gly 
625                 630                 635                 640 


Gln Pro Ala Met Leu Thr Phe Arg Thr Ser 
                645                 650 


<210>  2571
<211>  243
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2571

Xaa Asn Tyr Leu Ile Leu Pro Ser Gly Asn Leu Gln Ile Leu Asn Val 
1               5                   10                  15      


Ser Leu Glu Asp Lys Gly Ser Tyr Lys Cys Ala Ala Tyr Asn Pro Val 
            20                  25                  30          


Thr His Gln Leu Lys Val Glu Pro Ile Gly Arg Lys Leu Leu Val Ser 
        35                  40                  45              


Arg Pro Ser Ser Asp Asp Val His Ile Leu His Pro Thr His Ser Gln 
    50                  55                  60                  


Ala Leu Ala Val Leu Ser Arg Ser Pro Val Thr Leu Glu Cys Val Val 
65                  70                  75                  80  


Ser Gly Val Pro Ala Pro Gln Val Tyr Trp Leu Lys Asp Gly Gln Asp 
                85                  90                  95      


Ile Ala Pro Gly Ser Asn Trp Arg Arg Leu Tyr Ser His Leu Ala Thr 
            100                 105                 110         


Asp Ser Val Asp Pro Ala Asp Ser Gly Asn Tyr Ser Cys Met Ala Gly 
        115                 120                 125             


Asn Lys Ser Gly Asp Val Lys Tyr Val Thr Tyr Met Val Asn Val Leu 
    130                 135                 140                 


Glu His Ala Ser Ile Ser Lys Gly Leu Gln Asp Gln Ile Val Ser Leu 
145                 150                 155                 160 


Gly Ala Thr Val His Phe Thr Cys Asp Val His Gly Asn Pro Ala Pro 
                165                 170                 175     


Asn Cys Thr Trp Phe His Asn Ala Gln Pro Ile His Pro Ser Ala Arg 
            180                 185                 190         


His Leu Thr Ala Gly Asn Gly Leu Lys Ile Ser Gly Val Thr Val Glu 
        195                 200                 205             


Asp Val Gly Met Tyr Gln Cys Val Ala Asp Asn Gly Ile Gly Phe Met 
    210                 215                 220                 


His Ser Thr Gly Arg Leu Glu Ile Glu Asn Gly Gln Glu Ile Tyr Val 
225                 230                 235                 240 


Gly Asn Val 
            


<210>  2572
<211>  529
<212>  PRT
<213>  Homo Sapiens

<400>  2572

Met Gly Ser Ser Arg Ala Pro Trp Met Gly Arg Val Gly Gly His Gly 
1               5                   10                  15      


Met Met Ala Leu Leu Leu Ala Gly Leu Leu Leu Pro Gly Thr Leu Ala 
            20                  25                  30          


Lys Ser Ile Gly Thr Phe Ser Asp Pro Cys Lys Asp Pro Thr Arg Ile 
        35                  40                  45              


Thr Ser Pro Asn Asp Pro Cys Leu Thr Gly Lys Gly Asp Ser Ser Gly 
    50                  55                  60                  


Phe Ser Ser Tyr Ser Gly Ser Ser Ser Ser Gly Ser Ser Ile Ser Ser 
65                  70                  75                  80  


Ala Arg Ser Ser Gly Gly Gly Ser Ser Gly Ser Ser Ser Gly Ser Ser 
                85                  90                  95      


Ile Ala Gln Gly Gly Ser Ala Gly Ser Phe Lys Pro Gly Thr Gly Tyr 
            100                 105                 110         


Ser Gln Val Ser Tyr Ser Ser Gly Ser Gly Ser Ser Leu Gln Gly Ala 
        115                 120                 125             


Ser Gly Ser Ser Gln Leu Gly Ser Ser Ser Ser His Ser Gly Asn Ser 
    130                 135                 140                 


Gly Ser His Ser Gly Ser Ser Ser Ser His Ser Ser Ser Ser Ser Ser 
145                 150                 155                 160 


Phe Gln Phe Ser Ser Ser Ser Phe Gln Val Gly Asn Gly Ser Ala Leu 
                165                 170                 175     


Pro Thr Asn Asp Asn Ser Tyr Arg Gly Ile Leu Asn Pro Ser Gln Pro 
            180                 185                 190         


Gly Gln Ser Ser Ser Ser Ser Gln Thr Phe Gly Val Ser Ser Ser Gly 
        195                 200                 205             


Gln Ser Val Ser Ser Asn Gln Arg Pro Cys Ser Ser Asp Ile Pro Asp 
    210                 215                 220                 


Ser Pro Cys Ser Gly Gly Pro Ile Val Ser His Ser Gly Pro Tyr Ile 
225                 230                 235                 240 


Pro Ser Ser His Ser Val Ser Gly Gly Gln Arg Pro Val Val Val Val 
                245                 250                 255     


Val Asp Gln His Gly Ser Gly Ala Pro Gly Val Val Gln Gly Pro Pro 
            260                 265                 270         


Cys Ser Asn Gly Gly Leu Pro Gly Lys Pro Cys Pro Pro Ile Thr Ser 
        275                 280                 285             


Val Asp Lys Ser Tyr Gly Gly Tyr Glu Val Val Gly Gly Ser Ser Asp 
    290                 295                 300                 


Ser Tyr Leu Val Pro Gly Met Thr Tyr Ser Lys Gly Lys Ile Tyr Pro 
305                 310                 315                 320 


Val Gly Tyr Phe Thr Lys Glu Asn Pro Val Lys Gly Ser Pro Gly Val 
                325                 330                 335     


Pro Ser Phe Ala Ala Gly Pro Pro Ile Ser Glu Gly Lys Tyr Phe Ser 
            340                 345                 350         


Ser Asn Pro Ile Ile Pro Ser Gln Ser Ala Ala Ser Ser Ala Ile Ala 
        355                 360                 365             


Phe Gln Pro Val Gly Thr Gly Gly Val Gln Leu Cys Gly Gly Gly Ser 
    370                 375                 380                 


Thr Gly Ser Lys Gly Pro Cys Ser Pro Ser Ser Ser Arg Val Pro Ser 
385                 390                 395                 400 


Ser Ser Ser Ile Ser Ser Ser Ser Gly Leu Pro Tyr His Pro Cys Gly 
                405                 410                 415     


Ser Ala Ser Gln Ser Pro Cys Ser Pro Pro Gly Thr Gly Ser Phe Ser 
            420                 425                 430         


Ser Ser Ser Ser Ser Gln Ser Ser Gly Lys Ile Ile Leu Gln Pro Cys 
        435                 440                 445             


Gly Ser Lys Ser Ser Ser Ser Gly His Pro Cys Met Ser Val Ser Ser 
    450                 455                 460                 


Leu Thr Leu Thr Gly Gly Pro Asp Gly Ser Pro His Pro Asp Pro Ser 
465                 470                 475                 480 


Ala Gly Ala Lys Pro Cys Gly Ser Ser Ser Ala Gly Lys Ile Pro Cys 
                485                 490                 495     


Arg Ser Ile Arg Asp Ile Leu Ala Gln Val Lys Pro Leu Gly Pro Gln 
            500                 505                 510         


Leu Ala Asp Pro Glu Val Phe Leu Pro Gln Gly Glu Leu Leu Asn Ser 
        515                 520                 525             


Pro 
    


<210>  2573
<211>  425
<212>  PRT
<213>  Homo Sapiens

<400>  2573

Met Ala Leu Thr Gly Tyr Ser Trp Leu Leu Leu Ser Ala Thr Phe Leu 
1               5                   10                  15      


Asn Val Gly Ala Glu Ile Ser Ile Thr Leu Glu Pro Ala Gln Pro Ser 
            20                  25                  30          


Glu Gly Asp Asn Val Thr Leu Val Val His Gly Leu Ser Gly Glu Leu 
        35                  40                  45              


Leu Ala Tyr Ser Trp Tyr Ala Gly Pro Thr Leu Ser Val Ser Tyr Leu 
    50                  55                  60                  


Val Ala Ser Tyr Ile Val Ser Thr Gly Asp Glu Thr Pro Gly Pro Ala 
65                  70                  75                  80  


His Thr Gly Arg Glu Ala Val Arg Pro Asp Gly Ser Leu Asp Ile Gln 
                85                  90                  95      


Gly Ile Leu Pro Arg His Ser Gly Thr Tyr Ile Leu Gln Thr Phe Asn 
            100                 105                 110         


Arg Gln Leu Gln Thr Glu Val Gly Tyr Gly His Val Gln Val His Glu 
        115                 120                 125             


Ile Leu Ala Gln Pro Thr Val Leu Ala Asn Ser Thr Ala Leu Val Glu 
    130                 135                 140                 


Arg Arg Asp Thr Leu Arg Leu Met Cys Ser Ser Pro Ser Pro Thr Ala 
145                 150                 155                 160 


Glu Val Arg Trp Phe Phe Asn Gly Gly Ala Leu Pro Val Ala Leu Arg 
                165                 170                 175     


Leu Gly Leu Ser Pro Asp Gly Arg Val Leu Ala Arg His Gly Ile Arg 
            180                 185                 190         


Arg Glu Glu Ala Gly Ala Tyr Gln Cys Glu Val Trp Asn Pro Val Ser 
        195                 200                 205             


Val Ser Arg Ser Glu Pro Ile Asn Leu Thr Val Tyr Phe Gly Pro Glu 
    210                 215                 220                 


Arg Val Ala Ile Leu Gln Asp Ser Thr Thr Arg Thr Gly Cys Thr Ile 
225                 230                 235                 240 


Lys Val Asp Phe Asn Thr Ser Leu Thr Leu Trp Cys Val Ser Arg Ser 
                245                 250                 255     


Cys Pro Glu Pro Glu Tyr Val Trp Thr Phe Asn Gly Gln Ala Leu Lys 
            260                 265                 270         


Asn Gly Gln Asp His Leu Asn Ile Ser Ser Met Thr Ala Ala Gln Glu 
        275                 280                 285             


Gly Thr Tyr Thr Cys Ile Ala Lys Asn Thr Lys Thr Leu Leu Ser Gly 
    290                 295                 300                 


Ser Ala Ser Val Val Val Lys Leu Ser Ala Ala Ala Val Ala Thr Met 
305                 310                 315                 320 


Ile Val Pro Val Pro Thr Lys Pro Thr Glu Gly Gln Asp Val Thr Leu 
                325                 330                 335     


Thr Val Gln Gly Tyr Pro Lys Asp Leu Leu Val Tyr Ala Trp Tyr Arg 
            340                 345                 350         


Gly Pro Ala Ser Glu Pro Asn Arg Leu Leu Ser Gln Leu Pro Ser Gly 
        355                 360                 365             


Thr Trp Ile Ala Gly Pro Ala His Thr Gly Arg Glu Val Gly Phe Pro 
    370                 375                 380                 


Asn Cys Ser Leu Leu Val Gln Lys Leu Asn Leu Thr Asp Thr Gly Arg 
385                 390                 395                 400 


Tyr Thr Leu Lys Thr Val Thr Val Gln Gly Lys Thr Glu Thr Leu Glu 
                405                 410                 415     


Val Glu Leu Gln Val Ala Pro Leu Gly 
            420                 425 


<210>  2574
<211>  425
<212>  PRT
<213>  Homo Sapiens

<400>  2574

Met Ala Leu Thr Gly Tyr Ser Trp Leu Leu Leu Ser Ala Thr Phe Leu 
1               5                   10                  15      


Asn Val Gly Ala Glu Ile Ser Ile Thr Leu Glu Pro Ala Gln Pro Ser 
            20                  25                  30          


Glu Gly Asp Asn Val Thr Leu Val Val His Gly Leu Ser Gly Glu Leu 
        35                  40                  45              


Leu Ala Tyr Ser Trp Tyr Ala Gly Pro Thr Leu Ser Val Ser Tyr Leu 
    50                  55                  60                  


Val Ala Ser Tyr Ile Val Ser Thr Gly Asp Glu Thr Pro Gly Pro Ala 
65                  70                  75                  80  


His Thr Gly Arg Glu Ala Val Arg Pro Asp Gly Ser Leu Asp Ile Gln 
                85                  90                  95      


Gly Ile Leu Pro Arg His Ser Gly Thr Tyr Ile Leu Gln Thr Phe Asn 
            100                 105                 110         


Arg Gln Leu Gln Thr Glu Val Gly Tyr Gly His Val Gln Val His Glu 
        115                 120                 125             


Ile Leu Ala Gln Pro Thr Val Leu Ala Asn Ser Thr Ala Leu Val Glu 
    130                 135                 140                 


Arg Arg Asp Thr Leu Arg Leu Met Cys Ser Ser Pro Ser Pro Thr Ala 
145                 150                 155                 160 


Glu Val Arg Trp Phe Phe Asn Gly Gly Ala Leu Pro Val Ala Leu Arg 
                165                 170                 175     


Leu Gly Leu Ser Pro Asp Gly Arg Val Leu Ala Arg His Gly Ile Arg 
            180                 185                 190         


Arg Glu Glu Ala Gly Ala Tyr Gln Cys Glu Val Trp Asn Pro Val Ser 
        195                 200                 205             


Val Ser Arg Ser Glu Pro Ile Asn Leu Thr Val Tyr Phe Gly Pro Glu 
    210                 215                 220                 


Arg Val Ala Ile Leu Gln Asp Ser Thr Thr Arg Thr Gly Cys Thr Ile 
225                 230                 235                 240 


Lys Val Asp Phe Asn Thr Ser Leu Thr Leu Trp Cys Val Ser Arg Ser 
                245                 250                 255     


Cys Pro Glu Pro Glu Tyr Val Trp Thr Phe Asn Gly Gln Ala Leu Lys 
            260                 265                 270         


Asn Gly Gln Asp His Leu Asn Ile Ser Ser Met Thr Ala Ala Gln Glu 
        275                 280                 285             


Gly Thr Tyr Thr Cys Ile Ala Lys Asn Thr Lys Thr Leu Leu Ser Gly 
    290                 295                 300                 


Ser Ala Ser Val Val Val Lys Leu Ser Ala Ala Ala Val Ala Thr Met 
305                 310                 315                 320 


Ile Val Pro Val Pro Thr Lys Pro Thr Glu Gly Gln Asp Val Thr Leu 
                325                 330                 335     


Thr Val Gln Gly Tyr Pro Lys Asp Leu Leu Val Tyr Ala Trp Tyr Arg 
            340                 345                 350         


Gly Pro Ala Ser Glu Pro Asn Arg Leu Leu Ser Gln Leu Pro Ser Gly 
        355                 360                 365             


Thr Trp Ile Ala Gly Pro Ala His Thr Gly Arg Glu Val Gly Phe Pro 
    370                 375                 380                 


Asn Cys Ser Leu Leu Val Gln Lys Leu Asn Leu Thr Asp Thr Gly Arg 
385                 390                 395                 400 


Tyr Thr Leu Lys Thr Val Thr Val Gln Gly Lys Thr Glu Thr Leu Glu 
                405                 410                 415     


Val Glu Leu Gln Val Ala Pro Leu Gly 
            420                 425 


<210>  2575
<211>  384
<212>  PRT
<213>  Homo Sapiens

<400>  2575

Met Asp Leu Ser Arg Pro Arg Trp Ser Leu Trp Arg Arg Val Phe Leu 
1               5                   10                  15      


Met Ala Ser Leu Leu Ala Cys Gly Ile Cys Gln Ala Ser Gly Gln Ile 
            20                  25                  30          


Phe Ile Thr Gln Thr Leu Gly Ile Lys Gly Tyr Arg Thr Val Val Ala 
        35                  40                  45              


Leu Asp Lys Val Pro Glu Asp Val Gln Glu Tyr Ser Trp Tyr Trp Gly 
    50                  55                  60                  


Ala Asn Asp Ser Ala Gly Asn Met Ile Ile Ser His Lys Pro Pro Ser 
65                  70                  75                  80  


Ala Gln Gln Pro Gly Pro Met Tyr Thr Gly Arg Glu Arg Val Asn Arg 
                85                  90                  95      


Glu Gly Ser Leu Leu Ile Arg Pro Thr Ala Leu Asn Asp Thr Gly Asn 
            100                 105                 110         


Tyr Thr Val Arg Val Val Ala Gly Asn Glu Thr Gln Arg Ala Thr Gly 
        115                 120                 125             


Trp Leu Glu Val Leu Glu Leu Gly Ser Asn Leu Gly Ile Ser Val Asn 
    130                 135                 140                 


Ala Ser Ser Leu Val Glu Asn Met Asp Ser Val Ala Ala Asp Cys Leu 
145                 150                 155                 160 


Thr Asn Val Thr Asn Ile Thr Trp Tyr Val Asn Asp Val Pro Thr Ser 
                165                 170                 175     


Ser Ser Asp Arg Met Thr Ile Ser Pro Asp Gly Lys Thr Leu Val Ile 
            180                 185                 190         


Leu Arg Val Ser Arg Tyr Asp Arg Thr Ile Gln Cys Met Ile Glu Ser 
        195                 200                 205             


Phe Pro Glu Ile Phe Gln Arg Ser Glu Arg Ile Ser Leu Thr Val Ala 
    210                 215                 220                 


Tyr Gly Pro Asp Tyr Val Leu Leu Arg Ser Asn Pro Asp Asp Phe Asn 
225                 230                 235                 240 


Gly Ile Val Thr Ala Glu Ile Gly Ser Gln Val Glu Met Glu Cys Ile 
                245                 250                 255     


Cys Tyr Ser Phe Leu Asp Leu Lys Tyr His Trp Ile His Asn Gly Ser 
            260                 265                 270         


Leu Leu Asn Phe Ser Asp Ala Lys Met Asn Leu Ser Ser Leu Ala Trp 
        275                 280                 285             


Glu Gln Met Gly Arg Tyr Arg Cys Thr Val Glu Asn Pro Val Thr Gln 
    290                 295                 300                 


Leu Ile Met Tyr Met Asp Val Arg Ile Gln Ala Pro His Glu Asp Leu 
305                 310                 315                 320 


Thr Cys Cys Pro Gln Arg Phe Leu His Leu Arg Ile His Gly Asp Val 
                325                 330                 335     


Pro His His Ala Asp Ser Ala Gly Trp Arg Leu His Leu Trp Ser Pro 
            340                 345                 350         


Asp Pro Cys Ser Asp Gln Pro Leu Leu Asn Gln Asp Lys Ser Gly Ser 
        355                 360                 365             


Met Ser Val His Pro Arg Pro Glu Asp Lys Thr Arg Arg Ala Ser Arg 
    370                 375                 380                 


<210>  2576
<211>  55
<212>  PRT
<213>  Homo Sapiens

<400>  2576

Met Glu Ile Pro Met Gly Thr Gln Gly Cys Phe Ser Lys Ser Leu Leu 
1               5                   10                  15      


Leu Ser Ala Ser Ile Leu Val Leu Trp Met Leu Gln Gly Ser Gln Ala 
            20                  25                  30          


Ala Leu Tyr Ile Gln Lys Ile Pro Glu Gln Pro Gln Lys Asn Gln Asp 
        35                  40                  45              


Leu Leu Leu Ser Val Gln Gly 
    50                  55  


<210>  2577
<211>  56
<212>  PRT
<213>  Homo Sapiens

<400>  2577

Met Glu Ile Pro Met Gly Thr Gln Gly Cys Phe Ser Lys Ser Leu Leu 
1               5                   10                  15      


Leu Ser Ala Ser Ile Leu Val Leu Trp Met Leu Gln Gly Ser Gln Ala 
            20                  25                  30          


Ala Leu Tyr Ile Gln Lys Ile Pro Glu Gln Pro Gln Lys Asn Gln Asp 
        35                  40                  45              


Leu Leu Leu Ser Val Gln Gly Val 
    50                  55      


<210>  2578
<211>  56
<212>  PRT
<213>  Homo Sapiens

<400>  2578

Met Glu Ile Pro Met Gly Thr Gln Gly Cys Phe Ser Lys Ser Leu Leu 
1               5                   10                  15      


Leu Ser Ala Ser Ile Leu Val Leu Trp Met Leu Gln Gly Ser Gln Ala 
            20                  25                  30          


Ala Leu Tyr Ile Gln Lys Ile Pro Glu Gln Pro Gln Lys Asn Gln Asp 
        35                  40                  45              


Leu Leu Leu Ser Val Gln Gly Val 
    50                  55      


<210>  2579
<211>  56
<212>  PRT
<213>  Homo Sapiens

<400>  2579

Met Glu Ile Pro Met Gly Thr Gln Gly Cys Phe Ser Lys Ser Leu Leu 
1               5                   10                  15      


Leu Ser Ala Ser Ile Leu Val Leu Trp Met Leu Gln Gly Ser Gln Ala 
            20                  25                  30          


Ala Leu Tyr Ile Gln Lys Ile Pro Glu Gln Pro Gln Lys Asn Gln Asp 
        35                  40                  45              


Leu Leu Leu Ser Val Gln Gly Val 
    50                  55      


<210>  2580
<211>  56
<212>  PRT
<213>  Homo Sapiens

<400>  2580

Met Glu Ile Pro Met Gly Thr Gln Gly Cys Phe Ser Lys Ser Leu Leu 
1               5                   10                  15      


Leu Ser Ala Ser Ile Leu Val Leu Trp Met Leu Gln Gly Ser Gln Ala 
            20                  25                  30          


Ala Leu Tyr Ile Gln Lys Ile Pro Glu Gln Pro Gln Lys Asn Gln Asp 
        35                  40                  45              


Leu Leu Leu Ser Val Gln Gly Val 
    50                  55      


<210>  2581
<211>  299
<212>  PRT
<213>  Homo Sapiens

<400>  2581

Met Glu Ile Pro Met Gly Thr Gln Gly Cys Phe Ser Lys Ser Leu Leu 
1               5                   10                  15      


Leu Ser Ala Ser Ile Leu Val Leu Trp Met Leu Gln Gly Ser Gln Ala 
            20                  25                  30          


Ala Leu Tyr Ile Gln Lys Ile Pro Glu Gln Pro Gln Lys Asn Gln Asp 
        35                  40                  45              


Leu Leu Leu Ser Val Gln Gly Val Pro Asp Thr Phe Gln Asp Phe Asn 
    50                  55                  60                  


Trp Tyr Leu Gly Glu Glu Thr Tyr Gly Gly Thr Arg Leu Phe Thr Tyr 
65                  70                  75                  80  


Ile Pro Gly Ile Gln Arg Pro Gln Arg Asp Gly Ser Ala Met Gly Gln 
                85                  90                  95      


Arg Asp Ile Val Gly Phe Pro Asn Gly Ser Met Leu Leu Arg Arg Ala 
            100                 105                 110         


Gln Pro Thr Asp Ser Gly Thr Tyr Gln Val Ala Ile Thr Ile Asn Ser 
        115                 120                 125             


Glu Trp Thr Met Lys Ala Lys Thr Glu Val Gln Val Ala Glu Lys Asn 
    130                 135                 140                 


Lys Glu Leu Pro Ser Thr His Leu Pro Thr Asn Ala Gly Ile Leu Ala 
145                 150                 155                 160 


Ala Thr Ile Ile Gly Ser Leu Ala Ala Gly Ala Leu Leu Ile Ser Cys 
                165                 170                 175     


Ile Ala Tyr Leu Leu Val Thr Arg Asn Trp Arg Gly Gln Ser His Arg 
            180                 185                 190         


Leu Pro Ala Pro Arg Gly Gln Gly Ser Leu Ser Ile Leu Cys Ser Ala 
        195                 200                 205             


Val Ser Pro Val Pro Ser Val Thr Pro Ser Thr Trp Met Ala Thr Thr 
    210                 215                 220                 


Glu Lys Pro Glu Leu Gly Pro Ala His Asp Ala Gly Asp Asn Asn Ile 
225                 230                 235                 240 


Tyr Glu Val Met Pro Ser Pro Val Leu Leu Val Ser Pro Ile Ser Asp 
                245                 250                 255     


Thr Arg Ser Ile Asn Pro Ala Arg Pro Leu Pro Thr Pro Pro His Leu 
            260                 265                 270         


Gln Ala Glu Pro Glu Asn His Gln Tyr Gln Asp Leu Leu Asn Pro Asp 
        275                 280                 285             


Pro Ala Pro Tyr Cys Gln Leu Val Pro Thr Ser 
    290                 295                 


<210>  2582
<211>  300
<212>  PRT
<213>  Homo Sapiens

<400>  2582

Met Glu Ile Pro Met Gly Thr Gln Gly Cys Phe Ser Lys Ser Leu Leu 
1               5                   10                  15      


Leu Ser Ala Ser Ile Leu Val Leu Trp Met Leu Gln Gly Ser Gln Ala 
            20                  25                  30          


Ala Leu Tyr Ile Gln Lys Ile Pro Glu Gln Pro Gln Lys Asn Gln Asp 
        35                  40                  45              


Leu Leu Leu Ser Val Gln Gly Val Pro Asp Thr Phe Gln Asp Phe Asn 
    50                  55                  60                  


Trp Tyr Leu Gly Glu Glu Thr Tyr Gly Gly Thr Arg Leu Phe Thr Tyr 
65                  70                  75                  80  


Ile Pro Gly Ile Gln Arg Pro Gln Arg Asp Gly Ser Ala Met Gly Gln 
                85                  90                  95      


Arg Asp Ile Val Gly Phe Pro Asn Gly Ser Met Leu Leu Arg Arg Ala 
            100                 105                 110         


Gln Pro Thr Asp Ser Gly Thr Tyr Gln Val Ala Ile Thr Ile Asn Ser 
        115                 120                 125             


Glu Trp Thr Met Lys Ala Lys Thr Glu Val Gln Val Ala Glu Lys Asn 
    130                 135                 140                 


Lys Glu Leu Pro Ser Thr His Leu Pro Thr Asn Ala Gly Ile Leu Ala 
145                 150                 155                 160 


Ala Thr Ile Ile Gly Ser Leu Ala Ala Gly Ala Leu Leu Ile Ser Cys 
                165                 170                 175     


Ile Ala Tyr Leu Leu Val Thr Arg Asn Trp Arg Gly Gln Ser His Arg 
            180                 185                 190         


Leu Pro Ala Pro Arg Gly Gln Gly Ser Leu Ser Ile Leu Cys Ser Ala 
        195                 200                 205             


Val Ser Pro Val Pro Ser Val Thr Pro Ser Thr Trp Met Ala Thr Thr 
    210                 215                 220                 


Glu Lys Pro Glu Leu Gly Pro Ala His Asp Ala Gly Asp Asn Asn Ile 
225                 230                 235                 240 


Tyr Glu Val Met Pro Ser Pro Val Leu Leu Val Ser Pro Ile Ser Asp 
                245                 250                 255     


Thr Arg Ser Ile Asn Pro Ala Arg Pro Leu Pro Thr Pro Pro His Leu 
            260                 265                 270         


Gln Ala Glu Pro Glu Asn His Gln Tyr Gln Gln Asp Leu Leu Asn Pro 
        275                 280                 285             


Asp Pro Ala Pro Tyr Cys Gln Leu Val Pro Thr Ser 
    290                 295                 300 


<210>  2583
<211>  346
<212>  PRT
<213>  Homo Sapiens

<400>  2583

Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile 
            100                 105                 110         


Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn 
        195                 200                 205             


Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser Val Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly Pro Asp Thr Pro 
225                 230                 235                 240 


Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly Ala Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln Tyr Ser Trp Arg 
            260                 265                 270         


Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu Phe Ile Ala Lys 
        275                 280                 285             


Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe Val Ser Asn Leu 
    290                 295                 300                 


Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile Thr Val Ser Ala 
305                 310                 315                 320 


Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr Val Gly Ile Met 
                325                 330                 335     


Ile Gly Val Leu Val Gly Val Ala Leu Ile 
            340                 345     


<210>  2584
<211>  702
<212>  PRT
<213>  Homo Sapiens

<400>  2584

Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile 
            100                 105                 110         


Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg 
    210                 215                 220                 


Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 
            260                 265                 270         


Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala 
305                 310                 315                 320 


Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu 
                325                 330                 335     


Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr 
            340                 345                 350         


Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg 
        355                 360                 365             


Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr 
    370                 375                 380                 


Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser 
385                 390                 395                 400 


Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp 
                405                 410                 415     


Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn 
            420                 425                 430         


Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser 
        435                 440                 445             


Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile 
    450                 455                 460                 


Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn 
465                 470                 475                 480 


Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val 
                485                 490                 495     


Ser Ala Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro 
            500                 505                 510         


Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln 
        515                 520                 525             


Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser 
    530                 535                 540                 


Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn 
545                 550                 555                 560 


Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser 
                565                 570                 575     


Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly 
            580                 585                 590         


Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly 
        595                 600                 605             


Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln 
    610                 615                 620                 


Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu 
625                 630                 635                 640 


Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe 
                645                 650                 655     


Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile 
            660                 665                 670         


Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr 
        675                 680                 685             


Val Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile 
    690                 695                 700         


<210>  2585
<211>  701
<212>  PRT
<213>  Homo Sapiens

<400>  2585

Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile 
            100                 105                 110         


Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg 
    210                 215                 220                 


Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 
            260                 265                 270         


Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Glu 
305                 310                 315                 320 


Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu Asp 
                325                 330                 335     


Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr Thr 
            340                 345                 350         


Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu 
        355                 360                 365             


Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg 
    370                 375                 380                 


Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser Val 
385                 390                 395                 400 


Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Asp 
                405                 410                 415     


Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn Leu 
            420                 425                 430         


Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp 
        435                 440                 445             


Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile Ser 
    450                 455                 460                 


Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn Asn 
465                 470                 475                 480 


Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val Ser 
                485                 490                 495     


Ala Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val 
            500                 505                 510         


Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln Asn 
        515                 520                 525             


Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro 
    530                 535                 540                 


Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val 
545                 550                 555                 560 


Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser Val 
                565                 570                 575     


Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly Pro 
            580                 585                 590         


Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly Ala 
        595                 600                 605             


Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln Tyr 
    610                 615                 620                 


Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu Phe 
625                 630                 635                 640 


Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe Val 
                645                 650                 655     


Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile Thr 
            660                 665                 670         


Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr Val 
        675                 680                 685             


Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile 
    690                 695                 700     


<210>  2586
<211>  702
<212>  PRT
<213>  Homo Sapiens

<400>  2586

Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile 
            100                 105                 110         


Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg 
    210                 215                 220                 


Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 
            260                 265                 270         


Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala 
305                 310                 315                 320 


Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu 
                325                 330                 335     


Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr 
            340                 345                 350         


Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg 
        355                 360                 365             


Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr 
    370                 375                 380                 


Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser 
385                 390                 395                 400 


Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp 
                405                 410                 415     


Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn 
            420                 425                 430         


Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser 
        435                 440                 445             


Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile 
    450                 455                 460                 


Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn 
465                 470                 475                 480 


Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val 
                485                 490                 495     


Ser Ala Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro 
            500                 505                 510         


Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln 
        515                 520                 525             


Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser 
    530                 535                 540                 


Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn 
545                 550                 555                 560 


Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser 
                565                 570                 575     


Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly 
            580                 585                 590         


Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly 
        595                 600                 605             


Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln 
    610                 615                 620                 


Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu 
625                 630                 635                 640 


Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe 
                645                 650                 655     


Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile 
            660                 665                 670         


Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr 
        675                 680                 685             


Val Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile 
    690                 695                 700         


<210>  2587
<211>  702
<212>  PRT
<213>  Homo Sapiens

<400>  2587

Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile 
            100                 105                 110         


Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg 
    210                 215                 220                 


Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 
            260                 265                 270         


Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala 
305                 310                 315                 320 


Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu 
                325                 330                 335     


Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr 
            340                 345                 350         


Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg 
        355                 360                 365             


Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr 
    370                 375                 380                 


Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser 
385                 390                 395                 400 


Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp 
                405                 410                 415     


Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn 
            420                 425                 430         


Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser 
        435                 440                 445             


Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile 
    450                 455                 460                 


Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn 
465                 470                 475                 480 


Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val 
                485                 490                 495     


Ser Ala Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro 
            500                 505                 510         


Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln 
        515                 520                 525             


Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser 
    530                 535                 540                 


Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn 
545                 550                 555                 560 


Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser 
                565                 570                 575     


Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly 
            580                 585                 590         


Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly 
        595                 600                 605             


Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln 
    610                 615                 620                 


Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu 
625                 630                 635                 640 


Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe 
                645                 650                 655     


Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile 
            660                 665                 670         


Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr 
        675                 680                 685             


Val Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile 
    690                 695                 700         


<210>  2588
<211>  524
<212>  PRT
<213>  Homo Sapiens

<400>  2588

Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile 
            100                 105                 110         


Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Pro 
    130                 135                 140                 


Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu Asp Glu 
145                 150                 155                 160 


Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
        195                 200                 205             


Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser Val Asp 
    210                 215                 220                 


His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Asp Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn Leu Ser 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         


Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile Ser Asn 
        275                 280                 285             


Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn Asn Ser 
    290                 295                 300                 


Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val Ser Ala 
305                 310                 315                 320 


Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu 
                325                 330                 335     


Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln Asn Thr 
            340                 345                 350         


Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg 
        355                 360                 365             


Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr 
    370                 375                 380                 


Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser Val Ser 
385                 390                 395                 400 


Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly Pro Asp 
                405                 410                 415     


Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly Ala Asn 
            420                 425                 430         


Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln Tyr Ser 
        435                 440                 445             


Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu Phe Ile 
    450                 455                 460                 


Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe Val Ser 
465                 470                 475                 480 


Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile Thr Val 
                485                 490                 495     


Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr Val Gly 
            500                 505                 510         


Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile 
        515                 520                 


<210>  2589
<211>  194
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2589

Xaa Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile Ile Gln Asn 
1               5                   10                  15      


Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp Leu Val Asn 
            20                  25                  30          


Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu Pro Lys Pro 
        35                  40                  45              


Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys Asp Ala Val 
    50                  55                  60                  


Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr Leu Trp Trp 
65                  70                  75                  80  


Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser Asn 
                85                  90                  95      


Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn Asp Thr Ala 
            100                 105                 110         


Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg Arg Ser Asp 
        115                 120                 125             


Ser Val Ile Leu Asn Val Leu Ser Glu Pro Pro Lys Pro Phe Ile Thr 
    130                 135                 140                 


Ser Asn Asn Ser Asn Pro Val Glu Asp Glu Asp Ala Val Ala Leu Thr 
145                 150                 155                 160 


Cys Glu Pro Glu Ile Gln Asn Thr Thr Tyr Leu Trp Trp Val Asn Asn 
                165                 170                 175     


Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser Asn Asp Asn Arg 
            180                 185                 190         


Thr Leu 
        


<210>  2590
<211>  141
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2590

Xaa Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly Lys 
1               5                   10                  15      


Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly Tyr 
            20                  25                  30          


Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile Gly 
        35                  40                  45              


Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser Gly 
    50                  55                  60                  


Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile Ile 
65                  70                  75                  80  


Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp Leu 
                85                  90                  95      


Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu Pro 
            100                 105                 110         


Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys Asp 
        115                 120                 125             


Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln Asn Thr 
    130                 135                 140     


<210>  2591
<211>  265
<212>  PRT
<213>  Homo Sapiens

<400>  2591

Met Gly Ser Pro Ser Ala Cys Pro Tyr Arg Val Cys Ile Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Leu Pro Asn 
            20                  25                  30          


Ser Ala Gln Thr Asn Ile Asp Val Val Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Val Val His Asn Glu Ser Gln Asn Leu Tyr Gly 
    50                  55                  60                  


Tyr Asn Trp Tyr Lys Gly Glu Arg Val His Ala Asn Tyr Arg Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Lys Asn Ile Ser Gln Glu Asn Ala Pro Gly Pro Ala His 
                85                  90                  95      


Asn Gly Arg Glu Thr Ile Tyr Pro Asn Gly Thr Leu Leu Ile Gln Asn 
            100                 105                 110         


Val Thr His Asn Asp Ala Gly Ile Tyr Thr Leu His Val Ile Lys Glu 
        115                 120                 125             


Asn Leu Val Asn Glu Glu Val Thr Arg Gln Phe Tyr Val Phe Ser Glu 
    130                 135                 140                 


Pro Pro Lys Pro Ser Ile Thr Ser Asn Asn Phe Asn Pro Val Glu Asn 
145                 150                 155                 160 


Lys Asp Ile Val Val Leu Thr Cys Gln Pro Glu Thr Gln Asn Thr Thr 
                165                 170                 175     


Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Leu Val Ser Pro Arg Leu 
            180                 185                 190         


Leu Leu Ser Thr Asp Asn Arg Thr Leu Val Leu Leu Ser Ala Thr Lys 
        195                 200                 205             


Asn Asp Ile Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Gly Ala 
    210                 215                 220                 


Ser Arg Ser Asp Pro Val Thr Leu Asn Val Arg Tyr Glu Ser Val Gln 
225                 230                 235                 240 


Ala Ser Ser Pro Asp Leu Ser Ala Gly Thr Ala Val Ser Ile Met Ile 
                245                 250                 255     


Gly Val Leu Ala Gly Met Ala Leu Ile 
            260                 265 


<210>  2592
<211>  265
<212>  PRT
<213>  Homo Sapiens

<400>  2592

Met Gly Ser Pro Ser Ala Cys Pro Tyr Arg Val Cys Ile Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Leu Pro Asn 
            20                  25                  30          


Ser Ala Gln Thr Asn Ile Asp Val Val Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Val Val His Asn Glu Ser Gln Asn Leu Tyr Gly 
    50                  55                  60                  


Tyr Asn Trp Tyr Lys Gly Glu Arg Val His Ala Asn Tyr Arg Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Lys Asn Ile Ser Gln Glu Asn Ala Pro Gly Pro Ala His 
                85                  90                  95      


Asn Gly Arg Glu Thr Ile Tyr Pro Asn Gly Thr Leu Leu Ile Gln Asn 
            100                 105                 110         


Val Thr His Asn Asp Ala Gly Ile Tyr Thr Leu His Val Ile Lys Glu 
        115                 120                 125             


Asn Leu Val Asn Glu Glu Val Thr Arg Gln Phe Tyr Val Phe Ser Glu 
    130                 135                 140                 


Pro Pro Lys Pro Ser Ile Thr Ser Asn Asn Phe Asn Pro Val Glu Asn 
145                 150                 155                 160 


Lys Asp Ile Val Val Leu Thr Cys Gln Pro Glu Thr Gln Asn Thr Thr 
                165                 170                 175     


Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Leu Val Ser Pro Arg Leu 
            180                 185                 190         


Leu Leu Ser Thr Asp Asn Arg Thr Leu Val Leu Leu Ser Ala Thr Lys 
        195                 200                 205             


Asn Asp Ile Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Gly Ala 
    210                 215                 220                 


Ser Arg Ser Asp Pro Val Thr Leu Asn Val Arg Tyr Glu Ser Val Gln 
225                 230                 235                 240 


Ala Ser Ser Pro Asp Leu Ser Ala Gly Thr Ala Val Ser Ile Met Ile 
                245                 250                 255     


Gly Val Leu Ala Gly Met Ala Leu Ile 
            260                 265 


<210>  2593
<211>  172
<212>  PRT
<213>  Homo Sapiens

<400>  2593

Met Gly Ser Pro Ser Ala Cys Pro Tyr Arg Val Cys Ile Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Leu Pro Asn 
            20                  25                  30          


Ser Ala Gln Thr Asn Ile Asp Val Val Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Val Val His Asn Glu Ser Gln Asn Leu Tyr Gly 
    50                  55                  60                  


Tyr Asn Trp Tyr Lys Gly Glu Arg Val His Ala Asn Tyr Arg Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Lys Asn Ile Ser Gln Glu Asn Ala Pro Gly Pro Ala His 
                85                  90                  95      


Asn Gly Arg Glu Thr Ile Tyr Pro Asn Gly Thr Leu Leu Ile Gln Asn 
            100                 105                 110         


Val Thr His Asn Asp Ala Gly Ile Tyr Thr Leu His Val Ile Lys Glu 
        115                 120                 125             


Asn Leu Val Asn Glu Glu Val Thr Arg Gln Phe Tyr Val Phe Tyr Glu 
    130                 135                 140                 


Ser Val Gln Ala Ser Ser Pro Asp Leu Ser Ala Gly Thr Ala Val Ser 
145                 150                 155                 160 


Ile Met Ile Gly Val Leu Ala Gly Met Ala Leu Ile 
                165                 170         


<210>  2594
<211>  349
<212>  PRT
<213>  Homo Sapiens

<400>  2594

Met Gly Pro Ile Ser Ala Pro Ser Cys Arg Trp Arg Ile Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Phe Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Ile Glu Ala Val Pro Ser Asn Ala Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Asp Pro Arg Gly 
    50                  55                  60                  


Tyr Asn Trp Tyr Lys Gly Glu Thr Val Asp Ala Asn Arg Arg Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Ser Asn Gln Gln Ile Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Asn Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Met Arg Asn Val 
            100                 105                 110         


Thr Arg Asn Asp Thr Gly Ser Tyr Thr Leu Gln Val Ile Lys Leu Asn 
        115                 120                 125             


Leu Met Ser Glu Glu Val Thr Gly Gln Phe Ser Val His Pro Glu Thr 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asn Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
        195                 200                 205             


Asp Val Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn 
    210                 215                 220                 


Phe Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Asp Thr Tyr Tyr His Ala Gly Val Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ser Gln Tyr Ser Trp Ser 
            260                 265                 270         


Val Asn Gly Thr Phe Gln Gln Tyr Thr Gln Lys Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Thr Lys Asn Ser Gly Ser Tyr Ala Cys His Thr Thr Asn Ser 
    290                 295                 300                 


Ala Thr Gly Arg Asn Arg Thr Thr Val Arg Met Ile Thr Val Ser Asp 
305                 310                 315                 320 


Ala Leu Val Gln Gly Ser Ser Pro Gly Leu Ser Ala Arg Ala Thr Val 
                325                 330                 335     


Ser Ile Met Ile Gly Val Leu Ala Arg Val Ala Leu Ile 
            340                 345                 


<210>  2595
<211>  51
<212>  PRT
<213>  Homo Sapiens

<400>  2595

Met Gly Pro Ile Ser Ala Pro Ser Cys Arg Trp Arg Ile Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Asp Ala Leu Val Gln Gly Ser Ser Pro Gly Leu 
            20                  25                  30          


Ser Ala Arg Ala Thr Val Ser Ile Met Ile Gly Val Leu Ala Arg Val 
        35                  40                  45              


Ala Leu Ile 
    50      


<210>  2596
<211>  756
<212>  PRT
<213>  Homo Sapiens

<400>  2596

Met Leu Thr Met Gly Arg Leu Gln Leu Val Val Leu Gly Leu Thr Cys 
1               5                   10                  15      


Cys Trp Ala Val Ala Ser Ala Ala Lys Leu Gly Ala Val Tyr Thr Glu 
            20                  25                  30          


Gly Gly Phe Val Glu Gly Val Asn Lys Lys Leu Gly Leu Leu Gly Asp 
        35                  40                  45              


Ser Val Asp Ile Phe Lys Gly Ile Pro Phe Ala Ala Pro Thr Lys Ala 
    50                  55                  60                  


Leu Glu Asn Pro Gln Pro His Pro Gly Trp Gln Gly Thr Leu Lys Ala 
65                  70                  75                  80  


Lys Asn Phe Lys Lys Arg Cys Leu Gln Ala Thr Ile Thr Gln Asp Ser 
                85                  90                  95      


Thr Tyr Gly Asp Glu Asp Cys Leu Tyr Leu Asn Ile Trp Val Pro Gln 
            100                 105                 110         


Gly Arg Lys Gln Val Ser Arg Asp Leu Pro Val Met Ile Trp Ile Tyr 
        115                 120                 125             


Gly Gly Ala Phe Leu Met Gly Ser Gly His Gly Ala Asn Phe Leu Asn 
    130                 135                 140                 


Asn Tyr Leu Tyr Asp Gly Glu Glu Ile Ala Thr Arg Gly Asn Val Ile 
145                 150                 155                 160 


Val Val Thr Phe Asn Tyr Arg Val Gly Pro Leu Gly Phe Leu Ser Thr 
                165                 170                 175     


Gly Asp Ala Asn Leu Pro Gly Asn Tyr Gly Leu Arg Asp Gln His Met 
            180                 185                 190         


Ala Ile Ala Trp Val Lys Arg Asn Ile Ala Ala Phe Gly Gly Asp Pro 
        195                 200                 205             


Asn Asn Ile Thr Leu Phe Gly Glu Ser Ala Gly Gly Ala Ser Val Ser 
    210                 215                 220                 


Leu Gln Thr Leu Ser Pro Tyr Asn Lys Gly Leu Ile Arg Arg Ala Ile 
225                 230                 235                 240 


Ser Gln Ser Gly Val Ala Leu Ser Pro Trp Val Ile Gln Lys Asn Pro 
                245                 250                 255     


Leu Phe Trp Ala Lys Lys Val Ala Glu Lys Val Gly Cys Pro Val Gly 
            260                 265                 270         


Asp Ala Ala Arg Met Ala Gln Cys Leu Lys Val Thr Asp Pro Arg Ala 
        275                 280                 285             


Leu Thr Leu Ala Tyr Lys Val Pro Leu Ala Gly Leu Glu Tyr Pro Met 
    290                 295                 300                 


Leu His Tyr Val Gly Phe Val Pro Val Ile Asp Gly Asp Phe Ile Pro 
305                 310                 315                 320 


Ala Asp Pro Ile Asn Leu Tyr Ala Asn Ala Ala Asp Ile Asp Tyr Ile 
                325                 330                 335     


Ala Gly Thr Asn Asn Met Asp Gly His Ile Phe Ala Ser Ile Asp Met 
            340                 345                 350         


Pro Ala Ile Asn Lys Gly Asn Lys Lys Val Thr Glu Glu Asp Phe Tyr 
        355                 360                 365             


Lys Leu Val Ser Glu Phe Thr Ile Thr Lys Gly Leu Arg Gly Ala Lys 
    370                 375                 380                 


Thr Thr Phe Asp Val Tyr Thr Glu Ser Trp Ala Gln Asp Pro Ser Gln 
385                 390                 395                 400 


Glu Asn Lys Lys Lys Thr Val Val Asp Phe Glu Thr Asp Val Leu Phe 
                405                 410                 415     


Leu Val Pro Thr Glu Ile Ala Leu Ala Gln His Arg Ala Asn Ala Lys 
            420                 425                 430         


Ser Ala Lys Thr Tyr Ala Tyr Leu Phe Ser His Pro Ser Arg Met Pro 
        435                 440                 445             


Val Tyr Pro Lys Trp Val Gly Ala Asp His Ala Asp Asp Ile Gln Tyr 
    450                 455                 460                 


Val Phe Gly Lys Pro Phe Ala Thr Pro Thr Gly Tyr Arg Pro Gln Asp 
465                 470                 475                 480 


Arg Thr Val Ser Lys Ala Met Ile Ala Tyr Trp Thr Asn Phe Ala Lys 
                485                 490                 495     


Thr Gly Asp Pro Asn Met Gly Asp Ser Ala Val Pro Thr His Trp Glu 
            500                 505                 510         


Pro Tyr Thr Thr Glu Asn Ser Gly Tyr Leu Glu Ile Thr Lys Lys Met 
        515                 520                 525             


Gly Ser Ser Ser Met Lys Arg Ser Leu Arg Thr Asn Phe Leu Arg Tyr 
    530                 535                 540                 


Trp Thr Leu Thr Tyr Leu Ala Leu Pro Thr Val Thr Asp Gln Glu Ala 
545                 550                 555                 560 


Thr Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val Pro Pro 
                565                 570                 575     


Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly 
            580                 585                 590         


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
        595                 600                 605             


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
    610                 615                 620                 


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
625                 630                 635                 640 


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
                645                 650                 655     


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
            660                 665                 670         


Val Pro Pro Thr Gly Asp Ala Gly Pro Pro Pro Val Pro Pro Thr Gly 
        675                 680                 685             


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
    690                 695                 700                 


Pro Val Thr Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr 
705                 710                 715                 720 


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Glu Ala 
                725                 730                 735     


Ala Pro Val Pro Pro Thr Asp Asp Ser Lys Glu Ala Gln Met Pro Ala 
            740                 745                 750         


Val Ile Arg Phe 
        755     


<210>  2597
<211>  269
<212>  PRT
<213>  Homo Sapiens

<400>  2597

Met Ile Arg Thr Leu Leu Leu Ser Thr Leu Val Ala Gly Ala Leu Ser 
1               5                   10                  15      


Cys Gly Asp Pro Thr Tyr Pro Pro Tyr Val Thr Arg Val Val Gly Gly 
            20                  25                  30          


Glu Glu Ala Arg Pro Asn Ser Trp Pro Trp Gln Val Ser Leu Gln Tyr 
        35                  40                  45              


Ser Ser Asn Gly Lys Trp Tyr His Thr Cys Gly Gly Ser Leu Ile Ala 
    50                  55                  60                  


Asn Ser Trp Val Leu Thr Ala Ala His Cys Ile Ser Ser Ser Arg Thr 
65                  70                  75                  80  


Tyr Arg Val Gly Leu Gly Arg His Asn Leu Tyr Val Ala Glu Ser Gly 
                85                  90                  95      


Ser Leu Ala Val Ser Val Ser Lys Ile Val Val His Lys Asp Trp Asn 
            100                 105                 110         


Ser Asn Gln Ile Ser Lys Gly Asn Asp Ile Ala Leu Leu Lys Leu Ala 
        115                 120                 125             


Asn Pro Val Ser Leu Thr Asp Lys Ile Gln Leu Ala Cys Leu Pro Pro 
    130                 135                 140                 


Ala Gly Thr Ile Leu Pro Asn Asn Tyr Pro Cys Tyr Val Thr Gly Trp 
145                 150                 155                 160 


Gly Arg Leu Gln Thr Asn Gly Ala Val Pro Asp Val Leu Gln Gln Gly 
                165                 170                 175     


Arg Leu Leu Val Val Asp Tyr Ala Thr Cys Ser Ser Ser Ala Trp Trp 
            180                 185                 190         


Gly Ser Ser Val Lys Thr Ser Met Ile Cys Ala Gly Gly Asp Gly Val 
        195                 200                 205             


Ile Ser Ser Cys Asn Gly Asp Ser Gly Gly Pro Leu Asn Cys Gln Ala 
    210                 215                 220                 


Ser Asp Gly Arg Trp Gln Val His Gly Ile Val Ser Phe Gly Ser Arg 
225                 230                 235                 240 


Leu Gly Cys Asn Tyr Tyr His Lys Pro Ser Val Phe Thr Arg Val Ser 
                245                 250                 255     


Asn Tyr Ile Asp Trp Ile Asn Ser Val Ile Ala Asn Asn 
            260                 265                 


<210>  2598
<211>  126
<212>  PRT
<213>  Homo Sapiens

<400>  2598

Cys Gly Val Ser Thr Tyr Ala Pro Asp Met Ser Arg Met Leu Gly Gly 
1               5                   10                  15      


Glu Glu Ala Arg Pro Asn Ser Trp Pro Trp Gln Val Ser Leu Gln Tyr 
            20                  25                  30          


Ser Ser Asn Gly Gln Trp Tyr His Thr Cys Gly Gly Ser Leu Ile Ala 
        35                  40                  45              


Asn Ser Trp Val Leu Thr Ala Ala His Cys Ile Arg Gln Ile Ile Lys 
    50                  55                  60                  


Ala His Lys Val Leu Gln Arg Cys Ser Leu Ile Leu Phe Phe Val Arg 
65                  70                  75                  80  


Asp Leu Cys Ser Ser Gln Leu Glu Leu Thr Gly Val Ser Ala Gly Ser 
                85                  90                  95      


Ser Gly Ile Tyr Arg Val Met Leu Gly Gln His Asn Leu Tyr Val Ala 
            100                 105                 110         


Glu Ser Gly Ser Leu Ala Val Ser Val Ser Lys Ile Val Val 
        115                 120                 125     


<210>  2599
<211>  269
<212>  PRT
<213>  Homo Sapiens

<400>  2599

Met Ile Arg Thr Leu Leu Leu Ser Thr Leu Val Ala Gly Ala Leu Ser 
1               5                   10                  15      


Cys Gly Val Ser Thr Tyr Ala Pro Asp Met Ser Arg Met Leu Gly Gly 
            20                  25                  30          


Glu Glu Ala Arg Pro Asn Ser Trp Pro Trp Gln Val Ser Leu Gln Tyr 
        35                  40                  45              


Ser Ser Asn Gly Gln Trp Tyr His Thr Cys Gly Gly Ser Leu Ile Ala 
    50                  55                  60                  


Asn Ser Trp Val Leu Thr Ala Ala His Cys Ile Ser Ser Ser Gly Ile 
65                  70                  75                  80  


Tyr Arg Val Met Leu Gly Gln His Asn Leu Tyr Val Ala Glu Ser Gly 
                85                  90                  95      


Ser Leu Ala Val Ser Val Ser Lys Ile Val Val His Lys Asp Trp Asn 
            100                 105                 110         


Ser Asp Gln Val Ser Lys Gly Asn Asp Ile Ala Leu Leu Lys Leu Ala 
        115                 120                 125             


Asn Pro Val Ser Leu Thr Asp Lys Ile Gln Leu Ala Cys Leu Pro Pro 
    130                 135                 140                 


Ala Gly Thr Ile Leu Pro Asn Asn Tyr Pro Cys Tyr Val Thr Gly Trp 
145                 150                 155                 160 


Gly Arg Leu Gln Thr Asn Gly Ala Leu Pro Asp Asp Leu Lys Gln Gly 
                165                 170                 175     


Gln Leu Leu Val Val Asp Tyr Ala Thr Cys Ser Ser Ser Gly Trp Trp 
            180                 185                 190         


Gly Ser Thr Val Lys Thr Asn Met Ile Cys Ala Gly Gly Asp Gly Val 
        195                 200                 205             


Ile Cys Thr Cys Asn Gly Asp Ser Gly Gly Pro Leu Asn Cys Gln Ala 
    210                 215                 220                 


Ser Asp Gly Arg Trp Glu Val His Gly Ile Gly Ser Leu Thr Ser Val 
225                 230                 235                 240 


Leu Gly Cys Asn Tyr Tyr Tyr Lys Pro Ser Ile Phe Thr Arg Val Ser 
                245                 250                 255     


Asn Tyr Asn Asp Trp Ile Asn Ser Val Ile Ala Asn Asn 
            260                 265                 


<210>  2600
<211>  121
<212>  PRT
<213>  Homo Sapiens

<400>  2600

Met Met Leu Arg Leu Leu Ser Ser Leu Leu Leu Val Ala Val Ala Ser 
1               5                   10                  15      


Gly Tyr Gly Pro Pro Ser Ser His Ser Ser Ser Arg Val Val His Gly 
            20                  25                  30          


Glu Asp Ala Val Pro Tyr Ser Trp Pro Trp Gln Val Ser Leu Gln Tyr 
        35                  40                  45              


Glu Lys Ser Gly Ser Phe Tyr His Thr Cys Gly Gly Ser Leu Ile Ala 
    50                  55                  60                  


Pro Asp Trp Val Val Thr Ala Gly His Cys Ile Ser Arg Asp Leu Thr 
65                  70                  75                  80  


Tyr Gln Val Val Leu Gly Glu Tyr Asn Leu Ala Val Lys Glu Gly Pro 
                85                  90                  95      


Glu Gln Val Ile Pro Ile Asn Ser Glu Glu Leu Phe Val His Pro Leu 
            100                 105                 110         


Trp Asn Arg Ser Cys Val Ala Cys Gly 
        115                 120     


<210>  2601
<211>  270
<212>  PRT
<213>  Homo Sapiens

<400>  2601

Met Met Leu Arg Leu Leu Ser Ser Leu Leu Leu Val Ala Val Ala Ser 
1               5                   10                  15      


Gly Tyr Gly Pro Pro Ser Ser His Ser Ser Ser Arg Val Val His Gly 
            20                  25                  30          


Glu Asp Ala Val Pro Tyr Ser Trp Pro Trp Gln Val Ser Leu Gln Tyr 
        35                  40                  45              


Glu Lys Ser Gly Ser Phe Tyr His Thr Cys Gly Gly Ser Leu Ile Ala 
    50                  55                  60                  


Pro Asp Trp Val Val Thr Ala Gly His Cys Ile Ser Arg Asp Leu Thr 
65                  70                  75                  80  


Tyr Gln Val Val Leu Gly Glu Tyr Asn Leu Ala Val Lys Glu Gly Pro 
                85                  90                  95      


Glu Gln Val Ile Pro Ile Asn Ser Glu Glu Leu Phe Val His Pro Leu 
            100                 105                 110         


Trp Asn Arg Ser Cys Val Ala Cys Gly Asn Asp Ile Ala Leu Ile Lys 
        115                 120                 125             


Leu Ser Arg Ser Ala Gln Leu Gly Asp Ala Val Gln Leu Ala Ser Leu 
    130                 135                 140                 


Pro Pro Ala Gly Asp Ile Leu Pro Asn Lys Thr Pro Cys Tyr Ile Thr 
145                 150                 155                 160 


Gly Trp Gly Arg Leu Tyr Thr Asn Gly Pro Leu Pro Asp Lys Leu Gln 
                165                 170                 175     


Gln Ala Arg Leu Pro Val Val Asp Tyr Lys His Cys Ser Arg Trp Asn 
            180                 185                 190         


Trp Trp Gly Ser Thr Val Lys Lys Thr Met Val Cys Ala Gly Gly Tyr 
        195                 200                 205             


Ile Arg Ser Gly Cys Asn Gly Asp Ser Gly Gly Pro Leu Asn Cys Pro 
    210                 215                 220                 


Thr Glu Asp Gly Gly Trp Gln Val His Gly Val Thr Ser Phe Val Ser 
225                 230                 235                 240 


Ala Phe Gly Cys Asn Phe Ile Trp Lys Pro Thr Val Phe Thr Arg Val 
                245                 250                 255     


Ser Ala Phe Ile Asp Trp Ile Glu Glu Thr Ile Ala Ser His 
            260                 265                 270 


<210>  2602
<211>  75
<212>  PRT
<213>  Homo Sapiens

<400>  2602

Trp Trp Gly Ser Thr Val Lys Lys Thr Met Val Cys Ala Gly Gly Tyr 
1               5                   10                  15      


Ile Arg Ser Gly Cys Asn Gly Asp Ser Gly Gly Pro Leu Asn Cys Pro 
            20                  25                  30          


Thr Glu Asp Gly Gly Trp Gln Val His Gly Val Thr Ser Phe Val Ser 
        35                  40                  45              


Ala Phe Gly Cys Asn Phe Ile Trp Lys Pro Thr Val Phe Thr Arg Val 
    50                  55                  60                  


Ser Ala Phe Ile Asp Trp Ile Glu Glu Gly Gly 
65                  70                  75  


<210>  2603
<211>  270
<212>  PRT
<213>  Homo Sapiens

<400>  2603

Met Met Leu Arg Leu Leu Ser Ser Leu Leu Leu Val Ala Val Ala Ser 
1               5                   10                  15      


Gly Tyr Gly Pro Pro Ser Ser Arg Pro Ser Ser Arg Val Val Asn Gly 
            20                  25                  30          


Glu Asp Ala Val Pro Tyr Ser Trp Pro Trp Gln Val Ser Leu Gln Tyr 
        35                  40                  45              


Glu Lys Ser Gly Ser Phe Tyr His Thr Cys Gly Gly Ser Leu Ile Ala 
    50                  55                  60                  


Pro Asp Trp Val Val Thr Ala Gly His Cys Ile Ser Ser Ser Arg Thr 
65                  70                  75                  80  


Tyr Gln Val Val Leu Gly Glu Tyr Asp Arg Ala Val Lys Glu Gly Pro 
                85                  90                  95      


Glu Gln Val Ile Pro Ile Asn Ser Gly Asp Leu Phe Val His Pro Leu 
            100                 105                 110         


Trp Asn Arg Ser Cys Val Ala Cys Gly Asn Asp Ile Ala Leu Ile Lys 
        115                 120                 125             


Leu Ser Arg Ser Ala Gln Leu Gly Asp Ala Val Gln Leu Ala Ser Leu 
    130                 135                 140                 


Pro Pro Ala Gly Asp Ile Leu Pro Asn Glu Thr Pro Cys Tyr Ile Thr 
145                 150                 155                 160 


Gly Trp Gly Arg Leu Tyr Thr Asn Gly Pro Leu Pro Asp Lys Leu Gln 
                165                 170                 175     


Glu Ala Leu Leu Pro Val Val Asp Tyr Glu His Cys Ser Arg Trp Asn 
            180                 185                 190         


Trp Trp Gly Ser Ser Val Lys Lys Thr Met Val Cys Ala Gly Gly Asp 
        195                 200                 205             


Ile Arg Ser Gly Cys Asn Gly Asp Ser Gly Gly Pro Leu Asn Cys Pro 
    210                 215                 220                 


Thr Glu Asp Gly Gly Trp Gln Val His Gly Val Thr Ser Phe Val Ser 
225                 230                 235                 240 


Ala Phe Gly Cys Asn Thr Arg Arg Lys Pro Thr Val Phe Thr Arg Val 
                245                 250                 255     


Ser Ala Phe Ile Asp Trp Ile Glu Glu Thr Ile Ala Ser His 
            260                 265                 270 


<210>  2604
<211>  164
<212>  PRT
<213>  Homo Sapiens

<400>  2604

Met Arg Ser Cys Tyr Val Ala Gln Ala Gly Leu Lys Leu Pro Gly Ser 
1               5                   10                  15      


Ser Asp Pro Pro Ala Ser Ala Ser Gln Ser Thr Arg Ile Thr Ala Ser 
            20                  25                  30          


Gly Tyr Gly Pro Pro Ser Ser Arg Pro Ser Ser Arg Val Val Asn Gly 
        35                  40                  45              


Glu Asp Ala Val Pro Tyr Ser Trp Pro Trp Gln Val Ser Leu Gln Tyr 
    50                  55                  60                  


Glu Lys Ser Gly Ser Phe Tyr His Thr Cys Gly Gly Ser Leu Ile Ala 
65                  70                  75                  80  


Pro Asp Trp Val Val Thr Ala Gly His Cys Ile Ser Ser Ser Arg Thr 
                85                  90                  95      


Tyr Gln Val Val Leu Gly Glu Tyr Asp Arg Ala Val Lys Glu Gly Pro 
            100                 105                 110         


Glu Gln Val Ile Pro Ile Asn Ser Gly Asp Leu Phe Val His Pro Leu 
        115                 120                 125             


Trp Asn Arg Ser Cys Val Ala Cys Gly Asn Asp Ile Ala Leu Ile Lys 
    130                 135                 140                 


Leu Ser Arg Ser Ala Gln Leu Gly Asp Ala Val Gln Leu Ala Ser Leu 
145                 150                 155                 160 


Pro Pro Ala Gly 
                


<210>  2605
<211>  180
<212>  PRT
<213>  Homo Sapiens

<400>  2605

Gln Val Ile Pro Ile Asn Ser Gly Asp Leu Phe Val His Pro Leu Trp 
1               5                   10                  15      


Asn Arg Ser Cys Val Ala Cys Gly Asn Asp Ile Ala Leu Ile Lys Leu 
            20                  25                  30          


Ser Arg Ser Ala Gln Leu Gly Asp Ala Val Gln Leu Ala Ser Leu Pro 
        35                  40                  45              


Pro Ala Gly Asp Ile Leu Pro Asn Glu Thr Pro Cys Tyr Ile Thr Gly 
    50                  55                  60                  


Trp Gly Arg Leu Tyr Thr Asn Gly Pro Leu Pro Asp Lys Leu Gln Glu 
65                  70                  75                  80  


Ala Leu Leu Pro Val Val Asp Tyr Glu His Cys Ser Arg Trp Asn Trp 
                85                  90                  95      


Trp Gly Ser Ser Val Lys Lys Thr Met Val Cys Ala Gly Gly Asp Ile 
            100                 105                 110         


Arg Ser Gly Cys Asn Gly Asp Ser Gly Gly Pro Leu Asn Cys Pro Thr 
        115                 120                 125             


Glu Asp Gly Gly Trp Gln Val His Gly Val Thr Ser Phe Val Ser Ala 
    130                 135                 140                 


Phe Gly Cys Asn Thr Arg Arg Lys Pro Thr Val Phe Thr Arg Val Ser 
145                 150                 155                 160 


Ala Phe Ile Asp Trp Ile Glu Glu Lys Leu Gln Gly Asn Lys Ala Pro 
                165                 170                 175     


Glu Ser Arg Thr 
            180 


<210>  2606
<211>  1361
<212>  PRT
<213>  Homo Sapiens

<400>  2606

Met Gly Ala Ala Gly Arg Gln Asp Phe Leu Phe Lys Ala Met Leu Thr 
1               5                   10                  15      


Ile Ser Trp Leu Thr Leu Thr Cys Phe Pro Gly Ala Thr Ser Thr Val 
            20                  25                  30          


Ala Ala Gly Cys Pro Asp Gln Ser Pro Glu Leu Gln Pro Trp Asn Pro 
        35                  40                  45              


Gly His Asp Gln Asp His His Val His Ile Gly Gln Gly Lys Thr Leu 
    50                  55                  60                  


Leu Leu Thr Ser Ser Ala Thr Val Tyr Ser Ile His Ile Ser Glu Gly 
65                  70                  75                  80  


Gly Lys Leu Val Ile Lys Asp His Asp Glu Pro Ile Val Leu Arg Thr 
                85                  90                  95      


Arg His Ile Leu Ile Asp Asn Gly Gly Glu Leu His Ala Gly Ser Ala 
            100                 105                 110         


Leu Cys Pro Phe Gln Gly Asn Phe Thr Ile Ile Leu Tyr Gly Arg Ala 
        115                 120                 125             


Asp Glu Gly Ile Gln Pro Asp Pro Tyr Tyr Gly Leu Lys Tyr Ile Gly 
    130                 135                 140                 


Val Gly Lys Gly Gly Ala Leu Glu Leu His Gly Gln Lys Lys Leu Ser 
145                 150                 155                 160 


Trp Thr Phe Leu Asn Lys Thr Leu His Pro Gly Gly Met Ala Glu Gly 
                165                 170                 175     


Gly Tyr Phe Phe Glu Arg Ser Trp Gly His Arg Gly Val Ile Val His 
            180                 185                 190         


Val Ile Asp Pro Lys Ser Gly Thr Val Ile His Ser Asp Arg Phe Asp 
        195                 200                 205             


Thr Tyr Arg Ser Lys Lys Glu Ser Glu Arg Leu Val Gln Tyr Leu Asn 
    210                 215                 220                 


Ala Val Pro Asp Gly Arg Ile Leu Ser Val Ala Val Asn Asp Glu Gly 
225                 230                 235                 240 


Ser Arg Asn Leu Asp Asp Met Ala Arg Lys Ala Met Thr Lys Leu Gly 
                245                 250                 255     


Ser Lys His Phe Leu His Leu Gly Phe Arg His Pro Trp Ser Phe Leu 
            260                 265                 270         


Thr Val Lys Gly Asn Pro Ser Ser Ser Val Glu Asp His Ile Glu Tyr 
        275                 280                 285             


His Gly His Arg Gly Ser Ala Ala Ala Arg Val Phe Lys Leu Phe Gln 
    290                 295                 300                 


Thr Glu His Gly Glu Tyr Phe Asn Val Ser Leu Ser Ser Glu Trp Val 
305                 310                 315                 320 


Gln Asp Val Glu Trp Thr Glu Trp Phe Asp His Asp Lys Val Ser Gln 
                325                 330                 335     


Thr Lys Gly Gly Glu Lys Ile Ser Asp Leu Trp Lys Ala His Pro Gly 
            340                 345                 350         


Lys Ile Cys Asn Arg Pro Ile Asp Ile Gln Ala Thr Thr Met Asp Gly 
        355                 360                 365             


Val Asn Leu Ser Thr Glu Val Val Tyr Lys Lys Gly Gln Asp Tyr Arg 
    370                 375                 380                 


Phe Ala Cys Tyr Asp Arg Gly Arg Ala Cys Arg Ser Tyr Arg Val Arg 
385                 390                 395                 400 


Phe Leu Cys Gly Lys Pro Val Arg Pro Lys Leu Thr Val Thr Ile Asp 
                405                 410                 415     


Thr Asn Val Asn Ser Thr Ile Leu Asn Leu Glu Asp Asn Val Gln Ser 
            420                 425                 430         


Trp Lys Pro Gly Asp Thr Leu Val Ile Ala Ser Thr Asp Tyr Ser Met 
        435                 440                 445             


Tyr Gln Ala Glu Glu Phe Gln Val Leu Pro Cys Arg Ser Cys Ala Pro 
    450                 455                 460                 


Asn Gln Val Lys Val Ala Gly Lys Pro Met Tyr Leu His Ile Gly Glu 
465                 470                 475                 480 


Glu Ile Asp Gly Val Asp Met Arg Ala Glu Val Gly Leu Leu Ser Arg 
                485                 490                 495     


Asn Ile Ile Val Met Gly Glu Met Glu Asp Lys Cys Tyr Pro Tyr Arg 
            500                 505                 510         


Asn His Ile Cys Asn Phe Phe Asp Phe Asp Thr Phe Gly Gly His Ile 
        515                 520                 525             


Lys Phe Ala Leu Gly Phe Lys Ala Ala His Leu Glu Gly Thr Glu Leu 
    530                 535                 540                 


Lys His Met Gly Gln Gln Leu Val Gly Gln Tyr Pro Ile His Phe His 
545                 550                 555                 560 


Leu Ala Gly Asp Val Asp Glu Arg Gly Gly Tyr Asp Pro Pro Thr Tyr 
                565                 570                 575     


Ile Arg Asp Leu Ser Ile His His Thr Phe Ser Arg Cys Val Thr Val 
            580                 585                 590         


His Gly Ser Asn Gly Leu Leu Ile Lys Asp Val Val Gly Tyr Asn Ser 
        595                 600                 605             


Leu Gly His Cys Phe Phe Thr Glu Asp Gly Pro Glu Glu Arg Asn Thr 
    610                 615                 620                 


Phe Asp His Cys Leu Gly Leu Leu Val Lys Ser Gly Thr Leu Leu Pro 
625                 630                 635                 640 


Ser Asp Arg Asp Ser Lys Met Cys Lys Met Ile Thr Glu Asp Ser Tyr 
                645                 650                 655     


Pro Gly Tyr Ile Pro Lys Pro Arg Gln Asp Cys Asn Ala Val Ser Thr 
            660                 665                 670         


Phe Trp Met Ala Asn Pro Asn Asn Asn Leu Ile Asn Cys Ala Ala Ala 
        675                 680                 685             


Gly Ser Glu Glu Thr Gly Phe Trp Phe Ile Phe His His Val Pro Thr 
    690                 695                 700                 


Gly Pro Ser Val Gly Met Tyr Ser Pro Gly Tyr Ser Glu His Ile Pro 
705                 710                 715                 720 


Leu Gly Lys Phe Tyr Asn Asn Arg Ala His Ser Asn Tyr Arg Ala Gly 
                725                 730                 735     


Met Ile Ile Asp Asn Gly Val Lys Thr Thr Glu Ala Ser Ala Lys Asp 
            740                 745                 750         


Lys Arg Pro Phe Leu Ser Ile Ile Ser Ala Arg Tyr Ser Pro His Gln 
        755                 760                 765             


Asp Ala Asp Pro Leu Lys Pro Arg Glu Pro Ala Ile Ile Arg His Phe 
    770                 775                 780                 


Ile Ala Tyr Lys Asn Gln Asp His Gly Ala Trp Leu Arg Gly Gly Asp 
785                 790                 795                 800 


Val Trp Leu Asp Ser Cys Arg Phe Ala Asp Asn Gly Ile Gly Leu Thr 
                805                 810                 815     


Leu Ala Ser Gly Gly Thr Phe Pro Tyr Asp Asp Gly Ser Lys Gln Glu 
            820                 825                 830         


Ile Lys Asn Ser Leu Phe Val Gly Glu Ser Gly Asn Val Gly Thr Glu 
        835                 840                 845             


Met Met Asp Asn Arg Ile Trp Gly Pro Gly Gly Leu Asp His Ser Gly 
    850                 855                 860                 


Arg Thr Leu Pro Ile Gly Gln Asn Phe Pro Ile Arg Gly Ile Gln Leu 
865                 870                 875                 880 


Tyr Asp Gly Pro Ile Asn Ile Gln Asn Cys Thr Phe Arg Lys Phe Val 
                885                 890                 895     


Ala Leu Glu Gly Arg His Thr Ser Ala Leu Ala Phe Arg Leu Asn Asn 
            900                 905                 910         


Ala Trp Gln Ser Cys Pro His Asn Asn Val Thr Gly Ile Ala Phe Glu 
        915                 920                 925             


Asp Val Pro Ile Thr Ser Arg Val Phe Phe Gly Glu Pro Gly Pro Trp 
    930                 935                 940                 


Phe Asn Gln Leu Asp Met Asp Gly Asp Lys Thr Ser Val Phe His Asp 
945                 950                 955                 960 


Val Asp Gly Ser Val Ser Glu Tyr Pro Gly Ser Tyr Leu Thr Lys Asn 
                965                 970                 975     


Asp Asn Trp Leu Val Arg His Pro Asp Cys Ile Asn Val Pro Asp Trp 
            980                 985                 990         


Arg Gly Ala Ile Cys Ser Gly Cys  Tyr Ala Gln Met Tyr  Ile Gln Ala 
        995                 1000                 1005             


Tyr Lys  Thr Ser Asn Leu Arg  Met Lys Ile Ile Lys  Asn Asp Phe 
    1010                 1015                 1020             


Pro Ser  His Pro Leu Tyr Leu  Glu Gly Ala Leu Thr  Arg Ser Thr 
    1025                 1030                 1035             


His Tyr  Gln Gln Tyr Gln Pro  Val Val Thr Leu Gln  Lys Gly Tyr 
    1040                 1045                 1050             


Thr Ile  His Trp Asp Gln Thr  Ala Pro Ala Glu Leu  Ala Ile Trp 
    1055                 1060                 1065             


Leu Ile  Asn Phe Asn Lys Gly  Asp Trp Ile Arg Val  Gly Leu Cys 
    1070                 1075                 1080             


Tyr Pro  Arg Gly Thr Thr Phe  Ser Ile Leu Ser Asp  Val His Asn 
    1085                 1090                 1095             


Arg Leu  Leu Lys Gln Thr Ser  Lys Thr Gly Val Phe  Val Arg Thr 
    1100                 1105                 1110             


Leu Gln  Met Asp Lys Val Glu  Gln Ser Tyr Pro Gly  Arg Ser His 
    1115                 1120                 1125             


Tyr Tyr  Trp Asp Glu Asp Ser  Gly Leu Leu Phe Leu  Lys Leu Lys 
    1130                 1135                 1140             


Ala Gln  Asn Glu Arg Glu Lys  Phe Ala Phe Cys Ser  Met Lys Gly 
    1145                 1150                 1155             


Cys Glu  Arg Ile Lys Ile Lys  Ala Leu Ile Pro Lys  Asn Ala Gly 
    1160                 1165                 1170             


Val Ser  Asp Cys Thr Ala Thr  Ala Tyr Pro Lys Phe  Thr Glu Arg 
    1175                 1180                 1185             


Ala Val  Val Asp Val Pro Met  Pro Lys Lys Leu Phe  Gly Ser Gln 
    1190                 1195                 1200             


Leu Lys  Thr Lys Asp His Phe  Leu Glu Val Lys Met  Glu Ser Ser 
    1205                 1210                 1215             


Lys Gln  His Phe Phe His Leu  Trp Asn Asp Phe Ala  Tyr Ile Glu 
    1220                 1225                 1230             


Val Asp  Gly Lys Lys Tyr Pro  Ser Ser Glu Asp Gly  Ile Gln Val 
    1235                 1240                 1245             


Val Val  Ile Asp Gly Asn Gln  Gly Arg Val Val Ser  His Thr Ser 
    1250                 1255                 1260             


Phe Arg  Asn Ser Ile Leu Gln  Gly Ile Pro Trp Gln  Leu Phe Asn 
    1265                 1270                 1275             


Tyr Val  Ala Thr Ile Pro Asp  Asn Ser Ile Val Leu  Met Ala Ser 
    1280                 1285                 1290             


Lys Gly  Arg Tyr Val Ser Arg  Gly Pro Trp Thr Arg  Val Leu Glu 
    1295                 1300                 1305             


Lys Leu  Gly Ala Asp Arg Gly  Leu Lys Leu Lys Glu  Gln Met Ala 
    1310                 1315                 1320             


Phe Val  Gly Phe Lys Gly Ser  Phe Arg Pro Ile Trp  Val Thr Leu 
    1325                 1330                 1335             


Asp Thr  Glu Asp His Lys Ala  Lys Ile Phe Gln Val  Val Pro Ile 
    1340                 1345                 1350             


Pro Val  Val Lys Lys Lys Lys  Leu 
    1355                 1360     


<210>  2607
<211>  1361
<212>  PRT
<213>  Homo Sapiens

<400>  2607

Met Gly Ala Ala Gly Arg Gln Asp Phe Leu Phe Lys Ala Met Leu Thr 
1               5                   10                  15      


Ile Ser Trp Leu Thr Leu Thr Cys Phe Pro Gly Ala Thr Ser Thr Val 
            20                  25                  30          


Ala Ala Gly Cys Pro Asp Gln Ser Pro Glu Leu Gln Pro Trp Asn Pro 
        35                  40                  45              


Gly His Asp Gln Asp His His Val His Ile Gly Gln Gly Lys Thr Leu 
    50                  55                  60                  


Leu Leu Thr Ser Ser Ala Thr Val Tyr Ser Ile His Ile Ser Glu Gly 
65                  70                  75                  80  


Gly Lys Leu Val Ile Lys Asp His Asp Glu Pro Ile Val Leu Arg Thr 
                85                  90                  95      


Arg His Ile Leu Ile Asp Asn Gly Gly Glu Leu His Ala Gly Ser Ala 
            100                 105                 110         


Leu Cys Pro Phe Gln Gly Asn Phe Thr Ile Ile Leu Tyr Gly Arg Ala 
        115                 120                 125             


Asp Glu Gly Ile Gln Pro Asp Pro Tyr Tyr Gly Leu Lys Tyr Ile Gly 
    130                 135                 140                 


Val Gly Lys Gly Gly Ala Leu Glu Leu His Gly Gln Lys Lys Leu Ser 
145                 150                 155                 160 


Trp Thr Phe Leu Asn Lys Thr Leu His Pro Gly Gly Met Ala Glu Gly 
                165                 170                 175     


Gly Tyr Phe Phe Glu Arg Ser Trp Gly His Arg Gly Val Ile Val His 
            180                 185                 190         


Val Ile Asp Pro Lys Ser Gly Thr Val Ile His Ser Asp Arg Phe Asp 
        195                 200                 205             


Thr Tyr Arg Ser Lys Lys Glu Ser Glu Arg Leu Val Gln Tyr Leu Asn 
    210                 215                 220                 


Ala Val Pro Asp Gly Arg Ile Leu Ser Val Ala Val Asn Asp Glu Gly 
225                 230                 235                 240 


Ser Arg Asn Leu Asp Asp Met Ala Arg Lys Ala Met Thr Lys Leu Gly 
                245                 250                 255     


Ser Lys His Phe Leu His Leu Gly Phe Arg His Pro Trp Ser Phe Leu 
            260                 265                 270         


Thr Val Lys Gly Asn Pro Ser Ser Ser Val Glu Asp His Ile Glu Tyr 
        275                 280                 285             


His Gly His Arg Gly Ser Ala Ala Ala Arg Val Phe Lys Leu Phe Gln 
    290                 295                 300                 


Thr Glu His Gly Glu Tyr Phe Asn Val Ser Leu Ser Ser Glu Trp Val 
305                 310                 315                 320 


Gln Asp Val Glu Trp Thr Glu Trp Phe Asp His Asp Lys Val Ser Gln 
                325                 330                 335     


Thr Lys Gly Gly Glu Lys Ile Ser Asp Leu Trp Lys Ala His Pro Gly 
            340                 345                 350         


Lys Ile Cys Asn Arg Pro Ile Asp Ile Gln Ala Thr Thr Met Asp Gly 
        355                 360                 365             


Val Asn Leu Ser Thr Glu Val Val Tyr Lys Lys Gly Gln Asp Tyr Arg 
    370                 375                 380                 


Phe Ala Cys Tyr Asp Arg Gly Arg Ala Cys Arg Ser Tyr Arg Val Arg 
385                 390                 395                 400 


Phe Leu Cys Gly Lys Pro Val Arg Pro Lys Leu Thr Val Thr Ile Asp 
                405                 410                 415     


Thr Asn Val Asn Ser Thr Ile Leu Asn Leu Glu Asp Asn Val Gln Ser 
            420                 425                 430         


Trp Lys Pro Gly Asp Thr Leu Val Ile Ala Ser Thr Asp Tyr Ser Met 
        435                 440                 445             


Tyr Gln Ala Glu Glu Phe Gln Val Leu Pro Cys Arg Ser Cys Ala Pro 
    450                 455                 460                 


Asn Gln Val Lys Val Ala Gly Lys Pro Met Tyr Leu His Ile Gly Glu 
465                 470                 475                 480 


Glu Ile Asp Gly Val Asp Met Arg Ala Glu Val Gly Leu Leu Ser Arg 
                485                 490                 495     


Asn Ile Ile Val Met Gly Glu Met Glu Asp Lys Cys Tyr Pro Tyr Arg 
            500                 505                 510         


Asn His Ile Cys Asn Phe Phe Asp Phe Asp Thr Phe Gly Gly His Ile 
        515                 520                 525             


Lys Phe Ala Leu Gly Phe Lys Ala Ala His Leu Glu Gly Thr Glu Leu 
    530                 535                 540                 


Lys His Met Gly Gln Gln Leu Val Gly Gln Tyr Pro Ile His Phe His 
545                 550                 555                 560 


Leu Ala Gly Asp Val Asp Glu Arg Gly Gly Tyr Asp Pro Pro Thr Tyr 
                565                 570                 575     


Ile Arg Asp Leu Ser Ile His His Thr Phe Ser Arg Cys Val Thr Val 
            580                 585                 590         


His Gly Ser Asn Gly Leu Leu Ile Lys Asp Val Val Gly Tyr Asn Ser 
        595                 600                 605             


Leu Gly His Cys Phe Phe Thr Glu Asp Gly Pro Glu Glu Arg Asn Thr 
    610                 615                 620                 


Phe Asp His Cys Leu Gly Leu Leu Val Lys Ser Gly Thr Leu Leu Pro 
625                 630                 635                 640 


Ser Asp Arg Asp Ser Lys Met Cys Lys Met Ile Thr Glu Asp Ser Tyr 
                645                 650                 655     


Pro Gly Tyr Ile Pro Lys Pro Arg Gln Asp Cys Asn Ala Val Ser Thr 
            660                 665                 670         


Phe Trp Met Ala Asn Pro Asn Asn Asn Leu Ile Asn Cys Ala Ala Ala 
        675                 680                 685             


Gly Ser Glu Glu Thr Gly Phe Trp Phe Ile Phe His His Val Pro Thr 
    690                 695                 700                 


Gly Pro Ser Val Gly Met Tyr Ser Pro Gly Tyr Ser Glu His Ile Pro 
705                 710                 715                 720 


Leu Gly Lys Phe Tyr Asn Asn Arg Ala His Ser Asn Tyr Arg Ala Gly 
                725                 730                 735     


Met Ile Ile Asp Asn Gly Val Lys Thr Thr Glu Ala Ser Ala Lys Asp 
            740                 745                 750         


Lys Arg Pro Phe Leu Ser Ile Ile Ser Ala Arg Tyr Ser Pro His Gln 
        755                 760                 765             


Asp Ala Asp Pro Leu Lys Pro Arg Glu Pro Ala Ile Ile Arg His Phe 
    770                 775                 780                 


Ile Ala Tyr Lys Asn Gln Asp His Gly Ala Trp Leu Arg Gly Gly Asp 
785                 790                 795                 800 


Val Trp Leu Asp Ser Cys Arg Phe Ala Asp Asn Gly Ile Gly Leu Thr 
                805                 810                 815     


Leu Ala Ser Gly Gly Thr Phe Pro Tyr Asp Asp Gly Ser Lys Gln Glu 
            820                 825                 830         


Ile Lys Asn Ser Leu Phe Val Gly Glu Ser Gly Asn Val Gly Thr Glu 
        835                 840                 845             


Met Met Asp Asn Arg Ile Trp Gly Pro Gly Gly Leu Asp His Ser Gly 
    850                 855                 860                 


Arg Thr Leu Pro Ile Gly Gln Asn Phe Pro Ile Arg Gly Ile Gln Leu 
865                 870                 875                 880 


Tyr Asp Gly Pro Ile Asn Ile Gln Asn Cys Thr Phe Arg Lys Phe Val 
                885                 890                 895     


Ala Leu Glu Gly Arg His Thr Ser Ala Leu Ala Phe Arg Leu Asn Asn 
            900                 905                 910         


Ala Trp Gln Ser Cys Pro His Asn Asn Val Thr Gly Ile Ala Phe Glu 
        915                 920                 925             


Asp Val Pro Ile Thr Ser Arg Val Phe Phe Gly Glu Pro Gly Pro Trp 
    930                 935                 940                 


Phe Asn Gln Leu Asp Met Asp Gly Asp Lys Thr Ser Val Phe His Asp 
945                 950                 955                 960 


Val Asp Gly Ser Val Ser Glu Tyr Pro Gly Ser Tyr Leu Thr Lys Asn 
                965                 970                 975     


Asp Asn Trp Leu Val Arg His Pro Asp Cys Ile Asn Val Pro Asp Trp 
            980                 985                 990         


Arg Gly Ala Ile Cys Ser Gly Cys  Tyr Ala Gln Met Tyr  Ile Gln Ala 
        995                 1000                 1005             


Tyr Lys  Thr Ser Asn Leu Arg  Met Lys Ile Ile Lys  Asn Asp Phe 
    1010                 1015                 1020             


Pro Ser  His Pro Leu Tyr Leu  Glu Gly Ala Leu Thr  Arg Ser Thr 
    1025                 1030                 1035             


His Tyr  Gln Gln Tyr Gln Pro  Val Val Thr Leu Gln  Lys Gly Tyr 
    1040                 1045                 1050             


Thr Ile  His Trp Asp Gln Thr  Ala Pro Ala Glu Leu  Ala Ile Trp 
    1055                 1060                 1065             


Leu Ile  Asn Phe Asn Lys Gly  Asp Trp Ile Arg Val  Gly Leu Cys 
    1070                 1075                 1080             


Tyr Pro  Arg Gly Thr Thr Phe  Ser Ile Leu Ser Asp  Val His Asn 
    1085                 1090                 1095             


Arg Leu  Leu Lys Gln Thr Ser  Lys Thr Gly Val Phe  Val Arg Thr 
    1100                 1105                 1110             


Leu Gln  Met Asp Lys Val Glu  Gln Ser Tyr Pro Gly  Arg Ser His 
    1115                 1120                 1125             


Tyr Tyr  Trp Asp Glu Asp Ser  Gly Leu Leu Phe Leu  Lys Leu Lys 
    1130                 1135                 1140             


Ala Gln  Asn Glu Arg Glu Lys  Phe Ala Phe Cys Ser  Met Lys Gly 
    1145                 1150                 1155             


Cys Glu  Arg Ile Lys Ile Lys  Ala Leu Ile Pro Lys  Asn Ala Gly 
    1160                 1165                 1170             


Val Ser  Asp Cys Thr Ala Thr  Ala Tyr Pro Lys Phe  Thr Glu Arg 
    1175                 1180                 1185             


Ala Val  Val Asp Val Pro Met  Pro Lys Lys Leu Phe  Gly Ser Gln 
    1190                 1195                 1200             


Leu Lys  Thr Lys Asp His Phe  Leu Glu Val Lys Met  Glu Ser Ser 
    1205                 1210                 1215             


Lys Gln  His Phe Phe His Leu  Trp Asn Asp Phe Ala  Tyr Ile Glu 
    1220                 1225                 1230             


Val Asp  Gly Lys Lys Tyr Pro  Ser Ser Glu Asp Gly  Ile Gln Val 
    1235                 1240                 1245             


Val Val  Ile Asp Gly Asn Gln  Gly Arg Val Val Ser  His Thr Ser 
    1250                 1255                 1260             


Phe Arg  Asn Ser Ile Leu Gln  Gly Ile Pro Trp Gln  Leu Phe Asn 
    1265                 1270                 1275             


Tyr Val  Ala Thr Ile Pro Asp  Asn Ser Ile Val Leu  Met Ala Ser 
    1280                 1285                 1290             


Lys Gly  Arg Tyr Val Ser Arg  Gly Pro Trp Thr Arg  Val Leu Glu 
    1295                 1300                 1305             


Lys Leu  Gly Ala Asp Arg Gly  Leu Lys Leu Lys Glu  Gln Met Ala 
    1310                 1315                 1320             


Phe Val  Gly Phe Lys Gly Ser  Phe Arg Pro Ile Trp  Val Thr Leu 
    1325                 1330                 1335             


Asp Thr  Glu Asp His Lys Ala  Lys Ile Phe Gln Val  Val Pro Ile 
    1340                 1345                 1350             


Pro Val  Val Lys Lys Lys Lys  Leu 
    1355                 1360     


<210>  2608
<211>  1361
<212>  PRT
<213>  Homo Sapiens

<400>  2608

Met Gly Ala Ala Gly Arg Gln Asp Phe Leu Phe Lys Ala Met Leu Thr 
1               5                   10                  15      


Ile Ser Trp Leu Thr Leu Thr Cys Phe Pro Gly Ala Thr Ser Thr Val 
            20                  25                  30          


Ala Ala Gly Cys Pro Asp Gln Ser Pro Glu Leu Gln Pro Trp Asn Pro 
        35                  40                  45              


Gly His Asp Gln Asp His His Val His Ile Gly Gln Gly Lys Thr Leu 
    50                  55                  60                  


Leu Leu Thr Ser Ser Ala Thr Val Tyr Ser Ile His Ile Ser Glu Gly 
65                  70                  75                  80  


Gly Lys Leu Val Ile Lys Asp His Asp Glu Pro Ile Val Leu Arg Thr 
                85                  90                  95      


Arg His Ile Leu Ile Asp Asn Gly Gly Glu Leu His Ala Gly Ser Ala 
            100                 105                 110         


Leu Cys Pro Phe Gln Gly Asn Phe Thr Ile Ile Leu Tyr Gly Arg Ala 
        115                 120                 125             


Asp Glu Gly Ile Gln Pro Asp Pro Tyr Tyr Gly Leu Lys Tyr Ile Gly 
    130                 135                 140                 


Val Gly Lys Gly Gly Ala Leu Glu Leu His Gly Gln Lys Lys Leu Ser 
145                 150                 155                 160 


Trp Thr Phe Leu Asn Lys Thr Leu His Pro Gly Gly Met Ala Glu Gly 
                165                 170                 175     


Gly Tyr Phe Phe Glu Arg Ser Trp Gly His Arg Gly Val Ile Val His 
            180                 185                 190         


Val Ile Asp Pro Lys Ser Gly Thr Val Ile His Ser Asp Arg Phe Asp 
        195                 200                 205             


Thr Tyr Arg Ser Lys Lys Glu Ser Glu Arg Leu Val Gln Tyr Leu Asn 
    210                 215                 220                 


Ala Val Pro Asp Gly Arg Ile Leu Ser Val Ala Val Asn Asp Glu Gly 
225                 230                 235                 240 


Ser Arg Asn Leu Asp Asp Met Ala Arg Lys Ala Met Thr Lys Leu Gly 
                245                 250                 255     


Ser Lys His Phe Leu His Leu Gly Phe Arg His Pro Trp Ser Phe Leu 
            260                 265                 270         


Thr Val Lys Gly Asn Pro Ser Ser Ser Val Glu Asp His Ile Glu Tyr 
        275                 280                 285             


His Gly His Arg Gly Ser Ala Ala Ala Arg Val Phe Lys Leu Phe Gln 
    290                 295                 300                 


Thr Glu His Gly Glu Tyr Phe Asn Val Ser Leu Ser Ser Glu Trp Val 
305                 310                 315                 320 


Gln Asp Val Glu Trp Thr Glu Trp Phe Asp His Asp Lys Val Ser Gln 
                325                 330                 335     


Thr Lys Gly Gly Glu Lys Ile Ser Asp Leu Trp Lys Ala His Pro Gly 
            340                 345                 350         


Lys Ile Cys Asn Arg Pro Ile Asp Ile Gln Ala Thr Thr Met Asp Gly 
        355                 360                 365             


Val Asn Leu Ser Thr Glu Val Val Tyr Lys Lys Gly Gln Asp Tyr Arg 
    370                 375                 380                 


Phe Ala Cys Tyr Asp Arg Gly Arg Ala Cys Arg Ser Tyr Arg Val Arg 
385                 390                 395                 400 


Phe Leu Cys Gly Lys Pro Val Arg Pro Lys Leu Thr Val Thr Ile Asp 
                405                 410                 415     


Thr Asn Val Asn Ser Thr Ile Leu Asn Leu Glu Asp Asn Val Gln Ser 
            420                 425                 430         


Trp Lys Pro Gly Asp Thr Leu Val Ile Ala Ser Thr Asp Tyr Ser Met 
        435                 440                 445             


Tyr Gln Ala Glu Glu Phe Gln Val Leu Pro Cys Arg Ser Cys Ala Pro 
    450                 455                 460                 


Asn Gln Val Lys Val Ala Gly Lys Pro Met Tyr Leu His Ile Gly Glu 
465                 470                 475                 480 


Glu Ile Asp Gly Val Asp Met Arg Ala Glu Val Gly Leu Leu Ser Arg 
                485                 490                 495     


Asn Ile Ile Val Met Gly Glu Met Glu Asp Lys Cys Tyr Pro Tyr Arg 
            500                 505                 510         


Asn His Ile Cys Asn Phe Phe Asp Phe Asp Thr Phe Gly Gly His Ile 
        515                 520                 525             


Lys Phe Ala Leu Gly Phe Lys Ala Ala His Leu Glu Gly Thr Glu Leu 
    530                 535                 540                 


Lys His Met Gly Gln Gln Leu Val Gly Gln Tyr Pro Ile His Phe His 
545                 550                 555                 560 


Leu Ala Gly Asp Val Asp Glu Arg Gly Gly Tyr Asp Pro Pro Thr Tyr 
                565                 570                 575     


Ile Arg Asp Leu Ser Ile His His Thr Phe Ser Arg Cys Val Thr Val 
            580                 585                 590         


His Gly Ser Asn Gly Leu Leu Ile Lys Asp Val Val Gly Tyr Asn Ser 
        595                 600                 605             


Leu Gly His Cys Phe Phe Thr Glu Asp Gly Pro Glu Glu Arg Asn Thr 
    610                 615                 620                 


Phe Asp His Cys Leu Gly Leu Leu Val Lys Ser Gly Thr Leu Leu Pro 
625                 630                 635                 640 


Ser Asp Arg Asp Ser Lys Met Cys Lys Met Ile Thr Glu Asp Ser Tyr 
                645                 650                 655     


Pro Gly Tyr Ile Pro Lys Pro Arg Gln Asp Cys Asn Ala Val Ser Thr 
            660                 665                 670         


Phe Trp Met Ala Asn Pro Asn Asn Asn Leu Ile Asn Cys Ala Ala Ala 
        675                 680                 685             


Gly Ser Glu Glu Thr Gly Phe Trp Phe Ile Phe His His Val Pro Thr 
    690                 695                 700                 


Gly Pro Ser Val Gly Met Tyr Ser Pro Gly Tyr Ser Glu His Ile Pro 
705                 710                 715                 720 


Leu Gly Lys Phe Tyr Asn Asn Arg Ala His Ser Asn Tyr Arg Ala Gly 
                725                 730                 735     


Met Ile Ile Asp Asn Gly Val Lys Thr Thr Glu Ala Ser Ala Lys Asp 
            740                 745                 750         


Lys Arg Pro Phe Leu Ser Ile Ile Ser Ala Arg Tyr Ser Pro His Gln 
        755                 760                 765             


Asp Ala Asp Pro Leu Lys Pro Arg Glu Pro Ala Ile Ile Arg His Phe 
    770                 775                 780                 


Ile Ala Tyr Lys Asn Gln Asp His Gly Ala Trp Leu Arg Gly Gly Asp 
785                 790                 795                 800 


Val Trp Leu Asp Ser Cys Arg Phe Ala Asp Asn Gly Ile Gly Leu Thr 
                805                 810                 815     


Leu Ala Ser Gly Gly Thr Phe Pro Tyr Asp Asp Gly Ser Lys Gln Glu 
            820                 825                 830         


Ile Lys Asn Ser Leu Phe Val Gly Glu Ser Gly Asn Val Gly Thr Glu 
        835                 840                 845             


Met Met Asp Asn Arg Ile Trp Gly Pro Gly Gly Leu Asp His Ser Gly 
    850                 855                 860                 


Arg Thr Leu Pro Ile Gly Gln Asn Phe Pro Ile Arg Gly Ile Gln Leu 
865                 870                 875                 880 


Tyr Asp Gly Pro Ile Asn Ile Gln Asn Cys Thr Phe Arg Lys Phe Val 
                885                 890                 895     


Ala Leu Glu Gly Arg His Thr Ser Ala Leu Ala Phe Arg Leu Asn Asn 
            900                 905                 910         


Ala Trp Gln Ser Cys Pro His Asn Asn Val Thr Gly Ile Ala Phe Glu 
        915                 920                 925             


Asp Val Pro Ile Thr Ser Arg Val Phe Phe Gly Glu Pro Gly Pro Trp 
    930                 935                 940                 


Phe Asn Gln Leu Asp Met Asp Gly Asp Lys Thr Ser Val Phe His Asp 
945                 950                 955                 960 


Val Asp Gly Ser Val Ser Glu Tyr Pro Gly Ser Tyr Leu Thr Lys Asn 
                965                 970                 975     


Asp Asn Trp Leu Val Arg His Pro Asp Cys Ile Asn Val Pro Asp Trp 
            980                 985                 990         


Arg Gly Ala Ile Cys Ser Gly Cys  Tyr Ala Gln Met Tyr  Ile Gln Ala 
        995                 1000                 1005             


Tyr Lys  Thr Ser Asn Leu Arg  Met Lys Ile Ile Lys  Asn Asp Phe 
    1010                 1015                 1020             


Pro Ser  His Pro Leu Tyr Leu  Glu Gly Ala Leu Thr  Arg Ser Thr 
    1025                 1030                 1035             


His Tyr  Gln Gln Tyr Gln Pro  Val Val Thr Leu Gln  Lys Gly Tyr 
    1040                 1045                 1050             


Thr Ile  His Trp Asp Gln Thr  Ala Pro Ala Glu Leu  Ala Ile Trp 
    1055                 1060                 1065             


Leu Ile  Asn Phe Asn Lys Gly  Asp Trp Ile Arg Val  Gly Leu Cys 
    1070                 1075                 1080             


Tyr Pro  Arg Gly Thr Thr Phe  Ser Ile Leu Ser Asp  Val His Asn 
    1085                 1090                 1095             


Arg Leu  Leu Lys Gln Thr Ser  Lys Thr Gly Val Phe  Val Arg Thr 
    1100                 1105                 1110             


Leu Gln  Met Asp Lys Val Glu  Gln Ser Tyr Pro Gly  Arg Ser His 
    1115                 1120                 1125             


Tyr Tyr  Trp Asp Glu Asp Ser  Gly Leu Leu Phe Leu  Lys Leu Lys 
    1130                 1135                 1140             


Ala Gln  Asn Glu Arg Glu Lys  Phe Ala Phe Cys Ser  Met Lys Gly 
    1145                 1150                 1155             


Cys Glu  Arg Ile Lys Ile Lys  Ala Leu Ile Pro Lys  Asn Ala Gly 
    1160                 1165                 1170             


Val Ser  Asp Cys Thr Ala Thr  Ala Tyr Pro Lys Phe  Thr Glu Arg 
    1175                 1180                 1185             


Ala Val  Val Asp Val Pro Met  Pro Lys Lys Leu Phe  Gly Ser Gln 
    1190                 1195                 1200             


Leu Lys  Thr Lys Asp His Phe  Leu Glu Val Lys Met  Glu Ser Ser 
    1205                 1210                 1215             


Lys Gln  His Phe Phe His Leu  Trp Asn Asp Phe Ala  Tyr Ile Glu 
    1220                 1225                 1230             


Val Asp  Gly Lys Lys Tyr Pro  Ser Ser Glu Asp Gly  Ile Gln Val 
    1235                 1240                 1245             


Val Val  Ile Asp Gly Asn Gln  Gly Arg Val Val Ser  His Thr Ser 
    1250                 1255                 1260             


Phe Arg  Asn Ser Ile Leu Gln  Gly Ile Pro Trp Gln  Leu Phe Asn 
    1265                 1270                 1275             


Tyr Val  Ala Thr Ile Pro Asp  Asn Ser Ile Val Leu  Met Ala Ser 
    1280                 1285                 1290             


Lys Gly  Arg Tyr Val Ser Arg  Gly Pro Trp Thr Arg  Val Leu Glu 
    1295                 1300                 1305             


Lys Leu  Gly Ala Asp Arg Gly  Leu Lys Leu Lys Glu  Gln Met Ala 
    1310                 1315                 1320             


Phe Val  Gly Phe Lys Gly Ser  Phe Arg Pro Ile Trp  Val Thr Leu 
    1325                 1330                 1335             


Asp Thr  Glu Asp His Lys Ala  Lys Ile Phe Gln Val  Val Pro Ile 
    1340                 1345                 1350             


Pro Val  Val Lys Lys Lys Lys  Leu 
    1355                 1360     


<210>  2609
<211>  76
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2609

Xaa Ile Asn Phe Asn Lys Gly Asp Trp Ile Arg Val Gly Leu Cys Tyr 
1               5                   10                  15      


Pro Arg Gly Thr Thr Phe Ser Ile Leu Ser Asp Val His Asn Arg Leu 
            20                  25                  30          


Leu Lys Gln Thr Ser Lys Thr Gly Val Phe Val Arg Thr Leu Gln Met 
        35                  40                  45              


Asp Lys Val Glu Gln Ser Tyr Pro Gly Arg Ser His Tyr Tyr Trp Asp 
    50                  55                  60                  


Glu Asp Ser Gly Lys Gln Arg Thr Ile Ser Trp Arg 
65                  70                  75      


<210>  2610
<211>  145
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2610

Xaa Arg Gly Ala Ile Cys Ser Gly Cys Tyr Ala Gln Met Tyr Ile Gln 
1               5                   10                  15      


Ala Tyr Lys Thr Ser Asn Leu Arg Met Lys Ile Ile Lys Asn Asp Phe 
            20                  25                  30          


Pro Ser His Pro Leu Tyr Leu Glu Gly Ala Leu Thr Arg Ser Thr His 
        35                  40                  45              


Tyr Gln Gln Tyr Gln Pro Val Val Thr Leu Gln Lys Gly Tyr Thr Ile 
    50                  55                  60                  


His Trp Asp Gln Thr Ala Pro Ala Glu Leu Ala Ile Trp Leu Ile Asn 
65                  70                  75                  80  


Phe Asn Lys Gly Asp Trp Ile Arg Val Gly Leu Cys Tyr Pro Arg Gly 
                85                  90                  95      


Thr Thr Phe Ser Ile Leu Ser Asp Val His Asn Arg Leu Leu Lys Gln 
            100                 105                 110         


Thr Ser Lys Thr Gly Val Phe Val Arg Thr Leu Gln Met Asp Lys Val 
        115                 120                 125             


Glu Gln Ser Tyr Pro Gly Arg Ser His Tyr Tyr Trp Asp Glu Asp Ser 
    130                 135                 140                 


Gly 
145 


<210>  2611
<211>  173
<212>  PRT
<213>  Homo Sapiens

<400>  2611

Glu Gln Asp Ser Phe Ile Glu Pro Tyr Ala Thr Thr Ser Gln Leu Arg 
1               5                   10                  15      


Pro Arg Pro Asn Trp Gln Ser Glu Met Gly Arg Arg Ser Ser Leu Pro 
            20                  25                  30          


Ser Phe Glu Thr Leu Asp Tyr Gly Asp Glu Glu Asp Ile Glu Thr Gln 
        35                  40                  45              


Leu Ser Ser Ser Gly Lys Glu Leu Gly Asp Val Ser Ala Arg Glu Asp 
    50                  55                  60                  


Arg Gly Gly His Ser Asp Asp Leu Tyr Ala Val Pro His Arg Asn Gln 
65                  70                  75                  80  


Val Pro Leu Leu His Glu Val Asn Ser Glu Asp Asp Glu Asn Ile Ser 
                85                  90                  95      


His Gln Asp Gly Phe Pro Gly Ser Pro Pro Ala Pro Gln Arg Thr Gln 
            100                 105                 110         


Gln Lys Asp Gly Lys His Pro Val Leu Asn Leu Lys Asp Glu Lys Pro 
        115                 120                 125             


Pro Leu Cys Glu Lys Pro Pro Pro Ser Pro Gly Pro Thr Leu Leu Gln 
    130                 135                 140                 


Asp Leu Trp Gly Val Ala Phe Leu Val Gly Asn Val Cys Gly Ala Ser 
145                 150                 155                 160 


Val Pro Leu Pro Glu Phe Leu Ser Cys Val Gln Glu Glu 
                165                 170             


<210>  2612
<211>  783
<212>  PRT
<213>  Homo Sapiens

<400>  2612

Met Leu Leu Gly Phe Arg Arg Gly Arg Arg Ser His Phe Lys His Ile 
1               5                   10                  15      


Ile His Gly Leu Leu Pro Ala Ala Ser Val Ala Pro Lys Ala Ala Val 
            20                  25                  30          


Pro Arg Thr Pro Pro Pro Arg Ser Pro Asn Pro Ser Pro Glu Arg Pro 
        35                  40                  45              


Arg Ser Ala Leu Ala Ala Ala Ile Leu Ala Thr Thr Leu Thr Gly Arg 
    50                  55                  60                  


Thr Val Ala Ile Pro Gln Pro Arg Gln Arg Ser Arg Ser Glu Ser Asp 
65                  70                  75                  80  


Val Ser Ser Val Glu Gln Asp Ser Phe Ile Glu Pro Tyr Ala Thr Thr 
                85                  90                  95      


Ser Gln Leu Arg Pro Arg Pro Asn Trp Gln Ser Glu Met Gly Arg Arg 
            100                 105                 110         


Ser Ser Leu Pro Ser Phe Glu Thr Leu Asp Tyr Gly Asp Glu Glu Asp 
        115                 120                 125             


Ile Glu Thr Gln Leu Ser Ser Ser Gly Lys Glu Leu Gly Asp Val Ser 
    130                 135                 140                 


Ala Arg Glu Asp Arg Gly Gly His Ser Asp Asp Leu Tyr Ala Val Pro 
145                 150                 155                 160 


His Arg Asn Gln Val Pro Leu Leu His Glu Val Asn Ser Glu Asp Asp 
                165                 170                 175     


Glu Asn Ile Ser His Gln Asp Gly Phe Pro Gly Ser Pro Pro Ala Pro 
            180                 185                 190         


Gln Arg Thr Gln Gln Lys Asp Gly Lys His Pro Val Leu Asn Leu Lys 
        195                 200                 205             


Asp Glu Lys Pro Pro Leu Cys Glu Lys Pro Pro Pro Ser Pro Asp Ile 
    210                 215                 220                 


Thr Gly Arg Ala Arg Gln Arg Tyr Thr Glu Ile Thr Arg Glu Lys Phe 
225                 230                 235                 240 


Glu Ala Leu Lys Glu Glu Asn Met Asp Leu Asn Asn Met Asn Gln Ser 
                245                 250                 255     


Leu Thr Leu Glu Leu Asn Thr Met Lys Gln Ala Met Lys Glu Leu Gln 
            260                 265                 270         


Leu Lys Leu Lys Gly Met Glu Lys Glu Lys Arg Lys Leu Lys Glu Ala 
        275                 280                 285             


Glu Lys Ala Ser Ser Gln Glu Val Ala Ala Pro Glu Leu Leu Tyr Leu 
    290                 295                 300                 


Arg Lys Gln Ala Gln Glu Leu Val Asp Glu Asn Asp Gly Leu Lys Met 
305                 310                 315                 320 


Thr Val His Arg Leu Asn Val Glu Leu Ser Arg Tyr Gln Thr Lys Phe 
                325                 330                 335     


Arg His Leu Ser Lys Glu Glu Ser Leu Asn Ile Glu Gly Leu Pro Ser 
            340                 345                 350         


Lys Gly Pro Ile Pro Pro Trp Leu Leu Asp Ile Lys Tyr Leu Ser Pro 
        355                 360                 365             


Leu Leu Leu Ala Tyr Glu Asp Met Met Lys Glu Lys Asp Glu Leu Asn 
    370                 375                 380                 


Ala Thr Leu Lys Glu Glu Met Arg Met Phe Arg Met Arg Val Gln Glu 
385                 390                 395                 400 


Val Val Lys Glu Asn Glu Glu Leu His Gln Glu Leu Asn Lys Ser Ser 
                405                 410                 415     


Ala Val Thr Ser Glu Glu Trp Arg Gln Leu Gln Thr Gln Ala Lys Leu 
            420                 425                 430         


Val Leu Glu Glu Asn Lys Leu Leu Leu Glu Gln Leu Glu Ile Gln Gln 
        435                 440                 445             


Arg Lys Ala Lys Asp Ser His Gln Glu Arg Leu Gln Glu Val Ser Lys 
    450                 455                 460                 


Leu Thr Lys Gln Leu Met Leu Leu Glu Ala Lys Thr His Gly Gln Glu 
465                 470                 475                 480 


Lys Glu Leu Ala Glu Asn Arg Glu Gln Leu Glu Ile Leu Arg Ala Lys 
                485                 490                 495     


Cys Gln Glu Leu Lys Thr His Ser Asp Gly Lys Ile Ala Val Glu Val 
            500                 505                 510         


His Lys Ser Ile Val Asn Glu Leu Lys Ser Gln Leu Gln Lys Glu Glu 
        515                 520                 525             


Glu Lys Glu Arg Ala Glu Met Glu Glu Leu Met Glu Lys Leu Thr Val 
    530                 535                 540                 


Leu Gln Ala Gln Lys Lys Ser Leu Leu Leu Glu Lys Asn Ser Leu Thr 
545                 550                 555                 560 


Glu Gln Asn Lys Ala Leu Glu Ala Glu Leu Glu Arg Ala Gln Lys Ile 
                565                 570                 575     


Asn Arg Lys Ser Gln Lys Lys Ile Glu Val Leu Lys Lys Gln Val Glu 
            580                 585                 590         


Lys Ala Met Gly Asn Glu Met Ser Ala His Gln Tyr Leu Ala Asn Leu 
        595                 600                 605             


Val Gly Leu Ala Glu Asn Ile Thr Gln Glu Arg Asp Ser Leu Met Cys 
    610                 615                 620                 


Leu Ala Lys Cys Leu Glu Ser Glu Lys Asp Gly Val Leu Asn Lys Val 
625                 630                 635                 640 


Ile Lys Ser Asn Ile Arg Leu Gly Lys Leu Glu Glu Lys Val Lys Gly 
                645                 650                 655     


Tyr Lys Lys Gln Ala Ala Leu Lys Leu Gly Asp Ile Ser His Arg Leu 
            660                 665                 670         


Leu Glu Gln Gln Glu Asp Phe Ala Gly Lys Thr Ala Gln Tyr Arg Gln 
        675                 680                 685             


Glu Met Arg His Leu His Gln Val Leu Lys Asp Lys Gln Glu Val Leu 
    690                 695                 700                 


Asp Gln Ala Leu Gln Gln Asn Arg Glu Met Glu Gly Glu Leu Glu Val 
705                 710                 715                 720 


Ile Trp Glu Ser Thr Phe Arg Glu Asn Arg Arg Ile Arg Glu Leu Leu 
                725                 730                 735     


Gln Asp Thr Leu Thr Arg Thr Gly Val Gln Asp Asn Pro Arg Ala Leu 
            740                 745                 750         


Val Ala Pro Ser Leu Asn Gly Val Ser Gln Ala Asp Leu Leu Asp Gly 
        755                 760                 765             


Cys Asp Val Cys Ser Tyr Asp Leu Lys Ser His Ala Pro Thr Cys 
    770                 775                 780             


<210>  2613
<211>  428
<212>  PRT
<213>  Homo Sapiens

<400>  2613

Met Leu Leu Gly Phe Arg Arg Gly Arg Arg Ser His Phe Lys His Ile 
1               5                   10                  15      


Ile His Gly Leu Leu Pro Ala Ala Ser Val Ala Pro Lys Ala Ala Val 
            20                  25                  30          


Pro Arg Thr Pro Pro Pro Arg Ser Pro Asn Pro Ser Pro Glu Arg Pro 
        35                  40                  45              


Arg Ser Ala Leu Ala Ala Ala Ile Leu Ala Thr Thr Leu Thr Gly Arg 
    50                  55                  60                  


Thr Val Ala Ile Pro Gln Pro Arg Gln Arg Ser Arg Ser Glu Ser Asp 
65                  70                  75                  80  


Val Ser Ser Val Glu Gln Asp Ser Phe Ile Glu Pro Tyr Ala Thr Thr 
                85                  90                  95      


Ser Gln Leu Arg Pro Arg Pro Asn Trp Gln Ser Glu Met Gly Arg Arg 
            100                 105                 110         


Ser Ser Leu Pro Ser Phe Glu Thr Leu Asp Tyr Gly Asp Glu Glu Asp 
        115                 120                 125             


Ile Glu Thr Gln Leu Ser Ser Ser Gly Lys Glu Leu Gly Asp Val Ser 
    130                 135                 140                 


Ala Arg Glu Asp Arg Gly Gly His Ser Asp Asp Leu Tyr Ala Val Pro 
145                 150                 155                 160 


His Arg Asn Gln Val Pro Leu Leu His Glu Val Asn Ser Glu Asp Asp 
                165                 170                 175     


Glu Asn Ile Ser His Gln Asp Gly Phe Pro Gly Ser Pro Pro Ala Pro 
            180                 185                 190         


Gln Arg Thr Gln Gln Lys Asp Gly Lys His Pro Val Leu Asn Leu Lys 
        195                 200                 205             


Asp Glu Lys Pro Pro Leu Cys Glu Lys Pro Pro Pro Ser Pro Asp Ile 
    210                 215                 220                 


Thr Gly Arg Ala Arg Gln Arg Tyr Thr Glu Ile Thr Arg Glu Lys Phe 
225                 230                 235                 240 


Glu Ala Leu Lys Glu Glu Asn Met Asp Leu Asn Asn Met Asn Gln Ser 
                245                 250                 255     


Leu Thr Leu Glu Leu Asn Thr Met Lys Gln Ala Met Lys Glu Leu Gln 
            260                 265                 270         


Leu Lys Leu Lys Gly Met Glu Lys Glu Lys Arg Lys Leu Lys Glu Ala 
        275                 280                 285             


Glu Lys Ala Ser Ser Gln Glu Val Ala Ala Pro Glu Leu Leu Tyr Leu 
    290                 295                 300                 


Arg Lys Gln Ala Gln Glu Leu Val Asp Glu Asn Asp Gly Leu Lys Met 
305                 310                 315                 320 


Thr Val His Arg Leu Asn Val Glu Leu Ser Arg Tyr Gln Thr Lys Phe 
                325                 330                 335     


Arg His Leu Ser Lys Glu Glu Ser Leu Asn Ile Glu Gly Leu Pro Ser 
            340                 345                 350         


Lys Gly Pro Ile Pro Pro Trp Leu Leu Asp Ile Lys Tyr Leu Ser Pro 
        355                 360                 365             


Leu Leu Leu Ala Tyr Glu Asp Met Met Lys Glu Lys Asp Glu Leu Asn 
    370                 375                 380                 


Ala Thr Leu Lys Ala Ser Ala Ser Asp Ser Ser Lys Thr Gly Phe Arg 
385                 390                 395                 400 


Gly Lys Gln Val Val Ala Gly Ala Val Gly Asp Ser Ala Lys Glu Ser 
                405                 410                 415     


Gln Gly Gln Pro Pro Gly Ala Pro Pro Arg Ser Phe 
            420                 425             


<210>  2614
<211>  356
<212>  PRT
<213>  Homo Sapiens

<400>  2614

Met Leu Leu Gly Phe Arg Arg Gly Arg Arg Ser His Phe Lys His Ile 
1               5                   10                  15      


Ile His Gly Leu Leu Pro Ala Ala Ser Val Ala Pro Lys Ala Ala Val 
            20                  25                  30          


Pro Arg Thr Pro Pro Pro Arg Ser Pro Asn Pro Ser Pro Glu Arg Pro 
        35                  40                  45              


Arg Ser Ala Leu Ala Ala Ala Ile Leu Ala Thr Thr Leu Thr Gly Arg 
    50                  55                  60                  


Thr Val Ala Ile Pro Gln Pro Arg Gln Arg Ser Arg Ser Glu Ser Asp 
65                  70                  75                  80  


Val Ser Ser Val Glu Gln Asp Ser Phe Ile Glu Pro Tyr Ala Thr Thr 
                85                  90                  95      


Ser Gln Leu Arg Pro Arg Pro Asn Trp Gln Ser Glu Met Gly Arg Arg 
            100                 105                 110         


Ser Ser Leu Pro Ser Phe Glu Thr Leu Asp Tyr Gly Asp Glu Glu Asp 
        115                 120                 125             


Ile Glu Thr Gln Leu Ser Ser Ser Gly Lys Glu Leu Gly Asp Val Ser 
    130                 135                 140                 


Ala Arg Glu Asp Arg Gly Gly His Ser Asp Asp Leu Tyr Ala Val Pro 
145                 150                 155                 160 


His Arg Asn Gln Val Pro Leu Leu His Glu Val Asn Ser Glu Asp Asp 
                165                 170                 175     


Glu Asn Ile Ser His Gln Asp Gly Phe Pro Gly Ser Pro Pro Ala Pro 
            180                 185                 190         


Gln Arg Thr Gln Gln Lys Asp Gly Lys His Pro Val Leu Asn Leu Lys 
        195                 200                 205             


Asp Glu Lys Pro Pro Leu Cys Glu Lys Pro Pro Pro Ser Pro Asp Ile 
    210                 215                 220                 


Thr Gly Arg Ala Arg Gln Arg Tyr Thr Glu Ile Thr Arg Glu Lys Phe 
225                 230                 235                 240 


Glu Ala Leu Lys Glu Glu Asn Met Asp Leu Asn Asn Met Asn Gln Ser 
                245                 250                 255     


Leu Thr Leu Glu Leu Asn Thr Met Lys Gln Ala Met Lys Glu Leu Gln 
            260                 265                 270         


Leu Lys Leu Lys Gly Met Glu Lys Glu Lys Arg Lys Leu Lys Glu Ala 
        275                 280                 285             


Glu Lys Ala Ser Ser Gln Glu Val Ala Ala Pro Glu Leu Leu Tyr Leu 
    290                 295                 300                 


Arg Lys Gln Ala Gln Glu Leu Val Asp Glu Asn Asp Gly Leu Lys Met 
305                 310                 315                 320 


Thr Val His Arg Leu Asn Val Glu Leu Ser Arg Tyr Gln Thr Lys Phe 
                325                 330                 335     


Arg His Leu Ser Lys Glu Glu Val Thr Phe Pro Ile Val Lys Ile Ser 
            340                 345                 350         


Phe Ser Asp Phe 
        355     


<210>  2615
<211>  80
<212>  PRT
<213>  Homo Sapiens

<400>  2615

Met Leu Leu Gly Phe Arg Arg Gly Arg Arg Ser His Phe Lys Gln Gly 
1               5                   10                  15      


Leu Ala Leu Ser Pro Arg Leu Glu Cys Ser Gly Ala Ile Ile Ala His 
            20                  25                  30          


Cys Ile Leu Glu Leu Leu Gly Ser Ser Asp Leu Pro Thr Pro Ala Ser 
        35                  40                  45              


Arg Gly Ala Glu Thr Thr Gly Ala Arg His Tyr Ser Arg Leu Ile Val 
    50                  55                  60                  


Gln Tyr Phe Cys Gly Asn Arg Asp Leu Ala Met Phe Leu Trp Trp Ser 
65                  70                  75                  80  


<210>  2616
<211>  217
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2616

Xaa Ala Ala Val Pro Arg Thr Pro Pro Pro Arg Ser Pro Asn Pro Ser 
1               5                   10                  15      


Pro Glu Arg Pro Arg Ser Ala Leu Ala Ala Ala Ile Leu Ala Thr Thr 
            20                  25                  30          


Leu Thr Gly Arg Thr Val Ala Ile Pro Gln Pro Arg Gln Arg Ser Arg 
        35                  40                  45              


Ser Glu Ser Asp Val Ser Ser Val Glu Gln Asp Ser Phe Ile Glu Pro 
    50                  55                  60                  


Tyr Ala Thr Thr Ser Gln Leu Arg Pro Arg Pro Asn Trp Gln Ser Glu 
65                  70                  75                  80  


Met Gly Arg Arg Ser Ser Leu Pro Ser Phe Glu Thr Leu Asp Tyr Gly 
                85                  90                  95      


Asp Glu Glu Asp Ile Glu Thr Gln Leu Ser Ser Ser Gly Lys Glu Leu 
            100                 105                 110         


Gly Asp Val Ser Ala Arg Glu Asp Arg Gly Gly His Ser Asp Asp Leu 
        115                 120                 125             


Tyr Ala Val Pro His Arg Asn Gln Val Pro Leu Leu His Glu Val Asn 
    130                 135                 140                 


Ser Glu Asp Asp Glu Asn Ile Ser His Gln Asp Gly Phe Pro Gly Ser 
145                 150                 155                 160 


Pro Pro Ala Pro Gln Arg Thr Gln Gln Lys Asp Gly Lys His Pro Val 
                165                 170                 175     


Leu Asn Leu Lys Asp Glu Lys Pro Pro Leu Cys Glu Lys Pro Pro Pro 
            180                 185                 190         


Ser Pro Gly Ile Cys Leu Leu Asn Tyr Ile Met Ile Glu Lys Leu Val 
        195                 200                 205             


Leu Glu Asn Ile Gln Ile Asn Phe Ile 
    210                 215         


<210>  2617
<211>  267
<212>  PRT
<213>  Homo Sapiens

<400>  2617

Met His Leu Leu Leu Phe Gln Leu Leu Val Leu Leu Pro Leu Gly Lys 
1               5                   10                  15      


Thr Thr Arg His Gln Asp Gly Arg Gln Asn Gln Ser Ser Leu Ser Pro 
            20                  25                  30          


Val Leu Leu Pro Arg Asn Gln Arg Glu Leu Pro Thr Gly Asn His Glu 
        35                  40                  45              


Glu Ala Glu Glu Lys Pro Asp Leu Phe Val Ala Val Pro His Leu Val 
    50                  55                  60                  


Ala Thr Ser Pro Ala Gly Glu Gly Gln Arg Gln Arg Glu Lys Met Leu 
65                  70                  75                  80  


Ser Arg Phe Gly Arg Phe Trp Lys Lys Pro Glu Arg Glu Met His Pro 
                85                  90                  95      


Ser Arg Asp Ser Asp Ser Glu Pro Phe Pro Pro Gly Thr Gln Ser Leu 
            100                 105                 110         


Ile Gln Pro Ile Asp Gly Met Lys Met Glu Lys Ser Pro Leu Arg Glu 
        115                 120                 125             


Glu Ala Lys Lys Phe Trp His His Phe Met Phe Arg Lys Thr Pro Ala 
    130                 135                 140                 


Ser Gln Gly Val Ile Leu Pro Ile Lys Ser His Glu Val His Trp Glu 
145                 150                 155                 160 


Thr Cys Arg Thr Val Pro Phe Ser Gln Thr Ile Thr His Glu Gly Cys 
                165                 170                 175     


Glu Lys Val Val Val Gln Asn Asn Leu Cys Phe Gly Lys Cys Gly Ser 
            180                 185                 190         


Val His Phe Pro Gly Ala Ala Gln His Ser His Thr Ser Cys Ser His 
        195                 200                 205             


Cys Leu Pro Ala Lys Phe Thr Thr Met His Leu Pro Leu Asn Cys Thr 
    210                 215                 220                 


Glu Leu Ser Ser Val Ile Lys Val Val Met Leu Val Glu Glu Cys Gln 
225                 230                 235                 240 


Cys Lys Val Lys Thr Glu His Glu Asp Gly His Ile Leu His Ala Gly 
                245                 250                 255     


Ser Gln Asp Ser Phe Ile Pro Gly Val Ser Ala 
            260                 265         


<210>  2618
<211>  64
<212>  PRT
<213>  Homo Sapiens

<400>  2618

Met Leu Gln Glu Trp Leu Ala Ala Val Gly Asp Asp Tyr Ala Ala Val 
1               5                   10                  15      


Val Trp Arg Pro Glu Gly Glu Pro Arg Phe Tyr Pro Asp Glu Glu Gly 
            20                  25                  30          


Pro Lys His Trp Thr Lys Glu Arg His Gln Phe Leu Met Glu Leu Lys 
        35                  40                  45              


Gln Glu Ala Leu Thr Phe Ala Arg Asn Trp Gly Ala Asp Tyr Ile Leu 
    50                  55                  60                  


<210>  2619
<211>  79
<212>  PRT
<213>  Homo Sapiens

<400>  2619

Met Leu Gln Glu Trp Leu Ala Ala Val Gly Asp Asp Tyr Ala Ala Val 
1               5                   10                  15      


Val Trp Arg Pro Glu Gly Glu Pro Arg Phe Tyr Pro Asp Glu Glu Gly 
            20                  25                  30          


Pro Lys His Trp Thr Lys Glu Arg His Gln Phe Leu Met Glu Leu Lys 
        35                  40                  45              


Gln Glu Ala Leu Thr Phe Ala Arg Asn Trp Gly Ala Asp Tyr Ile Leu 
    50                  55                  60                  


Phe Ala Asp Thr Asp Asn Ile Leu Thr Asn Asn Gln Thr Leu Arg 
65                  70                  75                  


<210>  2620
<211>  109
<212>  PRT
<213>  Homo Sapiens

<400>  2620

Met Leu Gln Glu Trp Leu Ala Ala Val Gly Asp Asp Tyr Ala Ala Val 
1               5                   10                  15      


Val Trp Arg Pro Glu Gly Glu Pro Arg Phe Tyr Pro Asp Glu Glu Gly 
            20                  25                  30          


Pro Lys His Trp Thr Lys Glu Arg His Gln Phe Leu Met Glu Leu Lys 
        35                  40                  45              


Gln Glu Ala Leu Thr Phe Ala Arg Asn Trp Gly Ala Asp Tyr Ile Leu 
    50                  55                  60                  


Phe Ala Asp Thr Asp Asn Ile Leu Thr Asn Asn Gln Thr Leu Arg Leu 
65                  70                  75                  80  


Leu Met Gly Gln Gly Leu Pro Val Val Ala Pro Met Leu Asp Ser Gln 
                85                  90                  95      


Thr Tyr Tyr Ser Asn Phe Trp Cys Gly Ile Thr Pro Gln 
            100                 105                 


<210>  2621
<211>  218
<212>  PRT
<213>  Homo Sapiens

<400>  2621

Met Leu Gln Glu Trp Leu Ala Ala Val Gly Asp Asp Tyr Ala Ala Val 
1               5                   10                  15      


Val Trp Arg Pro Glu Gly Glu Pro Arg Phe Tyr Pro Asp Glu Glu Gly 
            20                  25                  30          


Pro Lys His Trp Thr Lys Glu Arg His Gln Phe Leu Met Glu Leu Lys 
        35                  40                  45              


Gln Glu Ala Leu Thr Phe Ala Arg Asn Trp Gly Ala Asp Tyr Ile Leu 
    50                  55                  60                  


Phe Ala Asp Thr Asp Asn Ile Leu Thr Asn Asn Gln Thr Leu Arg Leu 
65                  70                  75                  80  


Leu Met Gly Gln Gly Leu Pro Val Val Ala Pro Met Leu Asp Ser Gln 
                85                  90                  95      


Thr Tyr Tyr Ser Asn Phe Trp Cys Gly Ile Thr Pro Gln Gly Tyr Tyr 
            100                 105                 110         


Arg Arg Thr Ala Glu Tyr Phe Pro Thr Lys Asn Arg Gln Arg Arg Gly 
        115                 120                 125             


Cys Phe Arg Val Pro Met Val His Ser Thr Phe Leu Ala Ser Leu Arg 
    130                 135                 140                 


Ala Glu Gly Ala Asp Gln Leu Ala Phe Tyr Pro Pro His Pro Asn Tyr 
145                 150                 155                 160 


Thr Trp Pro Phe Asp Asp Ile Ile Val Phe Ala Tyr Ala Cys Gln Ala 
                165                 170                 175     


Ala Gly Val Ser Val His Val Cys Asn Glu His Arg Tyr Gly Tyr Met 
            180                 185                 190         


Asn Val Pro Val Lys Ser His Gln Gly Leu Glu Asp Glu Arg Val Asn 
        195                 200                 205             


Phe Ile His Leu Ile Leu Glu Ala Leu Gly 
    210                 215             


<210>  2622
<211>  517
<212>  PRT
<213>  Homo Sapiens

<400>  2622

Met Leu Gln Glu Trp Leu Ala Ala Val Gly Asp Asp Tyr Ala Ala Val 
1               5                   10                  15      


Val Trp Arg Pro Glu Gly Glu Pro Arg Phe Tyr Pro Asp Glu Glu Gly 
            20                  25                  30          


Pro Lys His Trp Thr Lys Glu Arg His Gln Phe Leu Met Glu Leu Lys 
        35                  40                  45              


Gln Glu Ala Leu Thr Phe Ala Arg Asn Trp Gly Ala Asp Tyr Ile Leu 
    50                  55                  60                  


Phe Ala Asp Thr Asp Asn Ile Leu Thr Asn Asn Gln Thr Leu Arg Leu 
65                  70                  75                  80  


Leu Met Gly Gln Gly Leu Pro Val Val Ala Pro Met Leu Asp Ser Gln 
                85                  90                  95      


Thr Tyr Tyr Ser Asn Phe Trp Cys Gly Ile Thr Pro Gln Gly Tyr Tyr 
            100                 105                 110         


Arg Arg Thr Ala Glu Tyr Phe Pro Thr Lys Asn Arg Gln Arg Arg Gly 
        115                 120                 125             


Cys Phe Arg Val Pro Met Val His Ser Thr Phe Leu Ala Ser Leu Arg 
    130                 135                 140                 


Ala Glu Gly Ala Asp Gln Leu Ala Phe Tyr Pro Pro His Pro Asn Tyr 
145                 150                 155                 160 


Thr Trp Pro Phe Asp Asp Ile Ile Val Phe Ala Tyr Ala Cys Gln Ala 
                165                 170                 175     


Ala Gly Val Ser Val His Val Cys Asn Glu His Arg Tyr Gly Tyr Met 
            180                 185                 190         


Asn Val Pro Val Lys Ser His Gln Gly Leu Glu Asp Glu Arg Val Asn 
        195                 200                 205             


Phe Ile His Leu Ile Leu Glu Ala Leu Val Asp Gly Pro Arg Met Gln 
    210                 215                 220                 


Ala Ser Ala His Val Thr Arg Pro Ser Lys Arg Pro Ser Lys Ile Gly 
225                 230                 235                 240 


Phe Asp Glu Val Phe Val Ile Ser Leu Ala Arg Arg Pro Asp Arg Arg 
                245                 250                 255     


Glu Arg Met Leu Ala Ser Leu Trp Glu Met Glu Ile Ser Gly Arg Val 
            260                 265                 270         


Val Asp Ala Val Asp Gly Trp Met Leu Asn Ser Ser Ala Ile Arg Asn 
        275                 280                 285             


Leu Gly Val Asp Leu Leu Pro Gly Tyr Gln Asp Pro Tyr Ser Gly Arg 
    290                 295                 300                 


Thr Leu Thr Lys Gly Glu Val Gly Cys Phe Leu Ser His Tyr Ser Ile 
305                 310                 315                 320 


Trp Glu Glu Val Val Ala Arg Gly Leu Ala Arg Val Leu Val Phe Glu 
                325                 330                 335     


Asp Asp Val Arg Phe Glu Ser Asn Phe Arg Gly Arg Leu Glu Arg Leu 
            340                 345                 350         


Met Glu Asp Val Glu Ala Glu Lys Leu Ser Trp Asp Leu Ile Tyr Leu 
        355                 360                 365             


Gly Arg Lys Gln Val Asn Pro Glu Lys Glu Thr Ala Val Glu Gly Leu 
    370                 375                 380                 


Pro Gly Leu Val Val Ala Gly Tyr Ser Tyr Trp Thr Leu Ala Tyr Ala 
385                 390                 395                 400 


Leu Arg Leu Ala Gly Ala Arg Lys Leu Leu Ala Ser Gln Pro Leu Arg 
                405                 410                 415     


Arg Met Leu Pro Val Asp Glu Phe Leu Pro Ile Met Phe Asp Gln His 
            420                 425                 430         


Pro Asn Glu Gln Tyr Lys Ala His Phe Trp Pro Arg Asp Leu Val Ala 
        435                 440                 445             


Phe Ser Ala Gln Pro Leu Leu Ala Ala Pro Thr His Tyr Ala Gly Asp 
    450                 455                 460                 


Ala Glu Trp Leu Ser Asp Thr Glu Thr Ser Ser Pro Trp Asp Asp Asp 
465                 470                 475                 480 


Ser Gly Arg Leu Ile Ser Trp Ser Gly Ser Gln Lys Thr Leu Arg Ser 
                485                 490                 495     


Pro Arg Leu Asp Leu Thr Gly Ser Ser Gly His Ser Leu Gln Pro Gln 
            500                 505                 510         


Pro Arg Asp Glu Leu 
        515         


<210>  2623
<211>  517
<212>  PRT
<213>  Homo Sapiens

<400>  2623

Met Leu Gln Glu Trp Leu Ala Ala Val Gly Asp Asp Tyr Ala Ala Val 
1               5                   10                  15      


Val Trp Arg Pro Glu Gly Glu Pro Arg Phe Tyr Pro Asp Glu Glu Gly 
            20                  25                  30          


Pro Lys His Trp Thr Lys Glu Arg His Gln Phe Leu Met Glu Leu Lys 
        35                  40                  45              


Gln Glu Ala Leu Thr Phe Ala Arg Asn Trp Gly Ala Asp Tyr Ile Leu 
    50                  55                  60                  


Phe Ala Asp Thr Asp Asn Ile Leu Thr Asn Asn Gln Thr Leu Arg Leu 
65                  70                  75                  80  


Leu Met Gly Gln Gly Leu Pro Val Val Ala Pro Met Leu Asp Ser Gln 
                85                  90                  95      


Thr Tyr Tyr Ser Asn Phe Trp Cys Gly Ile Thr Pro Gln Gly Tyr Tyr 
            100                 105                 110         


Arg Arg Thr Ala Glu Tyr Phe Pro Thr Lys Asn Arg Gln Arg Arg Gly 
        115                 120                 125             


Cys Phe Arg Val Pro Met Val His Ser Thr Phe Leu Ala Ser Leu Arg 
    130                 135                 140                 


Ala Glu Gly Ala Asp Gln Leu Ala Phe Tyr Pro Pro His Pro Asn Tyr 
145                 150                 155                 160 


Thr Trp Pro Phe Asp Asp Ile Ile Val Phe Ala Tyr Ala Cys Gln Ala 
                165                 170                 175     


Ala Gly Val Ser Val His Val Cys Asn Glu His Arg Tyr Gly Tyr Met 
            180                 185                 190         


Asn Val Pro Val Lys Ser His Gln Gly Leu Glu Asp Glu Arg Val Asn 
        195                 200                 205             


Phe Ile His Leu Ile Leu Glu Ala Leu Val Asp Gly Pro Arg Met Gln 
    210                 215                 220                 


Ala Ser Ala His Val Thr Arg Pro Ser Lys Arg Pro Ser Lys Ile Gly 
225                 230                 235                 240 


Phe Asp Glu Val Phe Val Ile Ser Leu Ala Arg Arg Pro Asp Arg Arg 
                245                 250                 255     


Glu Arg Met Leu Ala Ser Leu Trp Glu Met Glu Ile Ser Gly Arg Val 
            260                 265                 270         


Val Asp Ala Val Asp Ala Gly Met Leu Asn Ser Ser Ala Ile Arg Asn 
        275                 280                 285             


Leu Gly Val Asp Leu Leu Pro Gly Tyr Gln Asp Pro Tyr Ser Gly Arg 
    290                 295                 300                 


Thr Leu Thr Lys Gly Glu Val Gly Cys Phe Leu Ser His Tyr Ser Ile 
305                 310                 315                 320 


Trp Glu Glu Val Val Ala Arg Gly Leu Ala Arg Val Leu Val Phe Glu 
                325                 330                 335     


Asp Asp Val Arg Phe Glu Ser Asn Phe Arg Gly Arg Leu Glu Arg Leu 
            340                 345                 350         


Met Glu Asp Val Glu Ala Glu Lys Leu Ser Trp Asp Leu Ile Tyr Leu 
        355                 360                 365             


Gly Arg Lys Gln Val Asn Pro Glu Lys Glu Thr Ala Val Glu Gly Leu 
    370                 375                 380                 


Pro Gly Leu Val Val Ala Gly Tyr Ser Tyr Trp Thr Leu Ala Tyr Ala 
385                 390                 395                 400 


Leu Arg Leu Ala Gly Ala Arg Lys Leu Leu Ala Ser Gln Pro Leu Arg 
                405                 410                 415     


Arg Met Leu Pro Val Asp Glu Phe Leu Pro Ile Met Phe Asp Gln His 
            420                 425                 430         


Pro Asn Glu Gln Tyr Lys Ala His Phe Trp Pro Arg Asp Leu Val Ala 
        435                 440                 445             


Phe Ser Ala Gln Pro Leu Leu Ala Ala Pro Thr His Tyr Ala Gly Asp 
    450                 455                 460                 


Ala Glu Trp Leu Ser Asp Thr Glu Thr Ser Ser Pro Trp Asp Asp Asp 
465                 470                 475                 480 


Ser Gly Arg Leu Ile Ser Trp Ser Gly Ser Gln Lys Thr Leu Arg Ser 
                485                 490                 495     


Pro Arg Leu Asp Leu Thr Gly Ser Ser Gly His Ser Leu Gln Pro Gln 
            500                 505                 510         


Pro Arg Asp Glu Leu 
        515         


<210>  2624
<211>  595
<212>  PRT
<213>  Homo Sapiens

<400>  2624

Met Arg Ala Ala Arg Ala Ala Pro Leu Leu Gln Leu Leu Leu Leu Leu 
1               5                   10                  15      


Gly Pro Trp Leu Glu Ala Ala Gly Val Ala Glu Ser Pro Leu Pro Ala 
            20                  25                  30          


Val Val Leu Ala Ile Leu Ala Arg Asn Ala Glu His Ser Leu Pro His 
        35                  40                  45              


Tyr Leu Gly Ala Leu Glu Arg Leu Asp Tyr Pro Arg Ala Arg Met Ala 
    50                  55                  60                  


Leu Trp Cys Ala Thr Asp His Asn Val Asp Asn Thr Thr Glu Met Leu 
65                  70                  75                  80  


Gln Glu Trp Leu Ala Ala Val Gly Asp Asp Tyr Ala Ala Val Val Trp 
                85                  90                  95      


Arg Pro Glu Gly Glu Pro Arg Phe Tyr Pro Asp Glu Glu Gly Pro Lys 
            100                 105                 110         


His Trp Thr Lys Glu Arg His Gln Phe Leu Met Glu Leu Lys Gln Glu 
        115                 120                 125             


Ala Leu Thr Phe Ala Arg Asn Trp Gly Ala Asp Tyr Ile Leu Phe Ala 
    130                 135                 140                 


Asp Thr Asp Asn Ile Leu Thr Asn Asn Gln Thr Leu Arg Leu Leu Met 
145                 150                 155                 160 


Gly Gln Gly Leu Pro Val Val Ala Pro Met Leu Asp Ser Gln Thr Tyr 
                165                 170                 175     


Tyr Ser Asn Phe Trp Cys Gly Ile Thr Pro Gln Gly Tyr Tyr Arg Arg 
            180                 185                 190         


Thr Ala Glu Tyr Phe Pro Thr Lys Asn Arg Gln Arg Arg Gly Cys Phe 
        195                 200                 205             


Arg Val Pro Met Val His Ser Thr Phe Leu Ala Ser Leu Arg Ala Glu 
    210                 215                 220                 


Gly Ala Asp Gln Leu Ala Phe Tyr Pro Pro His Pro Asn Tyr Thr Trp 
225                 230                 235                 240 


Pro Phe Asp Asp Ile Ile Val Phe Ala Tyr Ala Cys Gln Ala Ala Gly 
                245                 250                 255     


Val Ser Val His Val Cys Asn Glu His Arg Tyr Gly Tyr Met Asn Val 
            260                 265                 270         


Pro Val Lys Ser His Gln Gly Leu Glu Asp Glu Arg Val Asn Phe Ile 
        275                 280                 285             


His Leu Ile Leu Glu Ala Leu Val Asp Gly Pro Arg Met Gln Ala Ser 
    290                 295                 300                 


Ala His Val Thr Arg Pro Ser Lys Arg Pro Ser Lys Ile Gly Phe Asp 
305                 310                 315                 320 


Glu Val Phe Val Ile Ser Leu Ala Arg Arg Pro Asp Arg Arg Glu Arg 
                325                 330                 335     


Met Leu Ala Ser Leu Trp Glu Met Glu Ile Ser Gly Arg Val Val Asp 
            340                 345                 350         


Ala Val Asp Gly Trp Met Leu Asn Ser Ser Ala Ile Arg Asn Leu Gly 
        355                 360                 365             


Val Asp Leu Leu Pro Gly Tyr Gln Asp Pro Tyr Ser Gly Arg Thr Leu 
    370                 375                 380                 


Thr Lys Gly Glu Val Gly Cys Phe Leu Ser His Tyr Ser Ile Trp Glu 
385                 390                 395                 400 


Glu Val Val Ala Arg Gly Leu Ala Arg Val Leu Val Phe Glu Asp Asp 
                405                 410                 415     


Val Arg Phe Glu Ser Asn Phe Arg Gly Arg Leu Glu Arg Leu Met Glu 
            420                 425                 430         


Asp Val Glu Ala Glu Lys Leu Ser Trp Asp Leu Ile Tyr Leu Gly Arg 
        435                 440                 445             


Lys Gln Val Asn Pro Glu Lys Glu Thr Ala Val Glu Gly Leu Pro Gly 
    450                 455                 460                 


Leu Val Val Ala Gly Tyr Ser Tyr Trp Thr Leu Ala Tyr Ala Leu Arg 
465                 470                 475                 480 


Leu Ala Gly Ala Arg Lys Leu Leu Ala Ser Gln Pro Leu Arg Arg Met 
                485                 490                 495     


Leu Pro Val Asp Glu Phe Leu Pro Ile Met Phe Asp Gln His Pro Asn 
            500                 505                 510         


Glu Gln Tyr Lys Ala His Phe Trp Pro Arg Asp Leu Val Ala Phe Ser 
        515                 520                 525             


Ala Gln Pro Leu Leu Ala Ala Pro Thr His Tyr Ala Gly Asp Ala Glu 
    530                 535                 540                 


Trp Leu Ser Asp Thr Glu Thr Ser Ser Pro Trp Asp Asp Asp Ser Gly 
545                 550                 555                 560 


Arg Leu Ile Ser Trp Ser Gly Ser Gln Lys Thr Leu Arg Ser Pro Arg 
                565                 570                 575     


Leu Asp Leu Thr Gly Ser Ser Gly His Ser Leu Gln Pro Gln Pro Arg 
            580                 585                 590         


Asp Glu Leu 
        595 


<210>  2625
<211>  155
<212>  PRT
<213>  Homo Sapiens

<400>  2625

Met Thr Ala Lys Gln Cys Pro Gly Ala Gly His Tyr Cys Pro Glu Ser 
1               5                   10                  15      


Arg Gly Gly Gly Cys Trp Gln Gly Leu Gln Ile Leu Ser Asp Leu Ala 
            20                  25                  30          


Thr Thr Leu Gly Met Ala Thr Leu Pro Ser Gly Pro Val Phe His Arg 
        35                  40                  45              


Glu Lys Pro Leu Arg Asp Gly Ser His Ser Leu Lys Val Ser Gln Gln 
    50                  55                  60                  


Arg Ser Arg Thr Pro Arg Pro Leu Tyr Pro Ala Trp Pro Asp Ser Gly 
65                  70                  75                  80  


Pro Cys Gly Pro Gln Leu Val Ser Ser Trp Ala Asp Pro Arg Ile Pro 
                85                  90                  95      


Ser Leu Pro Lys Asp Ser Ala Glu Gly Pro Leu Cys Pro Phe Tyr Leu 
            100                 105                 110         


His Leu Ser Thr Leu Pro Gln Leu Asp Val Trp Val Ser Pro Ala Pro 
        115                 120                 125             


Ser Ser Leu Ala Gly Ala Lys Tyr Arg Glu Val Lys Gln Asp Pro Cys 
    130                 135                 140                 


Arg His Val Ala Gln His Thr Val Gly Pro Gln 
145                 150                 155 


<210>  2626
<211>  337
<212>  PRT
<213>  Homo Sapiens

<400>  2626

Met Ala Ala Ala Gly Pro Ala Ala Gly Pro Thr Gly Pro Glu Pro Met 
1               5                   10                  15      


Pro Ser Tyr Ala Gln Leu Val Gln Arg Gly Trp Gly Ser Ala Leu Ala 
            20                  25                  30          


Ala Ala Arg Gly Cys Thr Asp Cys Gly Trp Gly Leu Ala Arg Arg Gly 
        35                  40                  45              


Leu Ala Glu His Ala His Leu Ala Pro Pro Glu Leu Leu Leu Leu Ala 
    50                  55                  60                  


Leu Gly Ala Leu Gly Trp Thr Ala Leu Arg Ser Ala Ala Thr Ala Arg 
65                  70                  75                  80  


Leu Phe Arg Pro Leu Ala Lys Arg Cys Cys Leu Gln Pro Arg Asp Ala 
                85                  90                  95      


Ala Lys Met Pro Glu Ser Ala Trp Lys Phe Leu Phe Tyr Leu Gly Ser 
            100                 105                 110         


Trp Ser Tyr Ser Ala Tyr Leu Leu Phe Gly Thr Asp Tyr Pro Phe Phe 
        115                 120                 125             


His Asp Pro Pro Ser Val Phe Tyr Asp Trp Thr Pro Gly Met Ala Val 
    130                 135                 140                 


Pro Arg Asp Ile Ala Ala Ala Tyr Leu Leu Gln Gly Ser Phe Tyr Gly 
145                 150                 155                 160 


His Ser Ile Tyr Ala Thr Leu Tyr Met Asp Thr Trp Arg Lys Asp Ser 
                165                 170                 175     


Val Val Met Leu Leu His His Val Val Thr Leu Ile Leu Ile Val Ser 
            180                 185                 190         


Ser Tyr Ala Phe Arg Tyr His Asn Val Gly Ile Leu Val Leu Phe Leu 
        195                 200                 205             


His Asp Ile Ser Asp Val Gln Leu Glu Phe Thr Lys Leu Asn Ile Tyr 
    210                 215                 220                 


Phe Lys Ser Arg Gly Gly Ser Tyr His Arg Leu His Ala Leu Ala Ala 
225                 230                 235                 240 


Asp Leu Gly Cys Leu Ser Phe Gly Phe Ser Trp Phe Trp Phe Arg Leu 
                245                 250                 255     


Tyr Trp Phe Pro Leu Lys Val Leu Tyr Ala Thr Ser His Cys Ser Leu 
            260                 265                 270         


Arg Thr Val Pro Asp Ile Pro Phe Tyr Phe Phe Phe Asn Ala Leu Leu 
        275                 280                 285             


Leu Leu Leu Thr Leu Met Asn Leu Tyr Trp Phe Leu Tyr Ile Val Ala 
    290                 295                 300                 


Phe Ala Ala Lys Val Leu Thr Gly Gln Val His Glu Leu Lys Asp Leu 
305                 310                 315                 320 


Arg Glu Tyr Asp Thr Ala Glu Ala Gln Ser Leu Lys Pro Ser Lys Ala 
                325                 330                 335     


Glu 
    


<210>  2627
<211>  350
<212>  PRT
<213>  Homo Sapiens

<400>  2627

Met Ala Ala Ala Gly Pro Ala Ala Gly Pro Thr Gly Pro Glu Pro Met 
1               5                   10                  15      


Pro Ser Tyr Ala Gln Leu Val Gln Arg Gly Trp Gly Ser Ala Leu Ala 
            20                  25                  30          


Ala Ala Arg Gly Cys Thr Asp Cys Gly Trp Gly Leu Ala Arg Arg Gly 
        35                  40                  45              


Leu Ala Glu His Ala His Leu Ala Pro Pro Glu Leu Leu Leu Leu Ala 
    50                  55                  60                  


Leu Gly Ala Leu Gly Trp Thr Ala Leu Arg Ser Ala Ala Thr Ala Arg 
65                  70                  75                  80  


Leu Phe Arg Pro Leu Ala Lys Arg Cys Cys Leu Gln Pro Arg Asp Ala 
                85                  90                  95      


Ala Lys Met Pro Glu Ser Ala Trp Lys Phe Leu Phe Tyr Leu Gly Ser 
            100                 105                 110         


Trp Ser Tyr Ser Ala Tyr Leu Leu Phe Gly Thr Asp Tyr Pro Phe Phe 
        115                 120                 125             


His Asp Pro Pro Ser Val Phe Tyr Asp Trp Thr Pro Gly Met Ala Val 
    130                 135                 140                 


Pro Arg Asp Ile Ala Ala Ala Tyr Leu Leu Gln Gly Ser Phe Tyr Gly 
145                 150                 155                 160 


His Ser Ile Tyr Ala Thr Leu Tyr Met Asp Thr Trp Arg Lys Asp Ser 
                165                 170                 175     


Val Val Met Leu Leu His His Val Val Thr Leu Ile Leu Ile Val Ser 
            180                 185                 190         


Ser Tyr Ala Phe Arg Tyr His Asn Val Gly Ile Leu Val Leu Phe Leu 
        195                 200                 205             


His Asp Ile Ser Asp Val Gln Leu Glu Phe Thr Lys Leu Asn Ile Tyr 
    210                 215                 220                 


Phe Lys Ser Arg Gly Gly Ser Tyr His Arg Leu His Ala Leu Ala Ala 
225                 230                 235                 240 


Asp Leu Gly Cys Leu Ser Phe Gly Phe Ser Trp Phe Trp Phe Arg Leu 
                245                 250                 255     


Tyr Trp Phe Pro Leu Lys Val Leu Tyr Ala Thr Ser His Cys Ser Leu 
            260                 265                 270         


Arg Thr Val Pro Asp Ile Pro Phe Tyr Phe Phe Phe Asn Ala Leu Leu 
        275                 280                 285             


Leu Leu Leu Thr Leu Met Asn Leu Tyr Trp Phe Leu Tyr Ile Val Ala 
    290                 295                 300                 


Phe Ala Ala Lys Val Leu Thr Gly Gln Val His Glu Leu Lys Asp Leu 
305                 310                 315                 320 


Arg Glu Tyr Asp Thr Ala Glu Ala Gln Ser Leu Lys Pro Ser Lys Ala 
                325                 330                 335     


Glu Lys Pro Leu Arg Asn Gly Leu Val Lys Asp Lys Arg Phe 
            340                 345                 350 


<210>  2628
<211>  239
<212>  PRT
<213>  Homo Sapiens

<400>  2628

Met Pro Glu Ser Ala Trp Lys Phe Leu Phe Tyr Leu Gly Ser Trp Ser 
1               5                   10                  15      


Tyr Ser Ala Tyr Leu Leu Phe Gly Thr Asp Tyr Pro Phe Phe His Asp 
            20                  25                  30          


Pro Pro Ser Val Phe Tyr Asp Trp Thr Pro Gly Met Ala Val Pro Arg 
        35                  40                  45              


Asp Ile Ala Ala Ala Tyr Leu Leu Gln Gly Ser Phe Tyr Gly His Ser 
    50                  55                  60                  


Ile Tyr Ala Thr Leu Tyr Met Asp Thr Trp Arg Lys Asp Ser Val Val 
65                  70                  75                  80  


Met Leu Leu His His Val Val Thr Leu Ile Leu Ile Val Ser Ser Tyr 
                85                  90                  95      


Ala Phe Arg Tyr His Asn Val Gly Ile Leu Val Leu Phe Leu His Asp 
            100                 105                 110         


Ile Ser Asp Val Gln Leu Glu Phe Thr Lys Leu Asn Ile Tyr Phe Lys 
        115                 120                 125             


Ser Arg Gly Gly Ser Tyr His Arg Leu His Ala Leu Ala Ala Asp Leu 
    130                 135                 140                 


Gly Cys Leu Ser Phe Gly Phe Ser Trp Phe Trp Phe Arg Leu Tyr Trp 
145                 150                 155                 160 


Phe Pro Leu Lys Val Leu Tyr Ala Thr Ser His Cys Ser Leu Arg Thr 
                165                 170                 175     


Val Pro Asp Ile Pro Phe Tyr Phe Phe Phe Asn Ala Leu Leu Leu Leu 
            180                 185                 190         


Leu Thr Leu Met Asn Leu Tyr Trp Phe Leu Tyr Ile Val Ala Phe Ala 
        195                 200                 205             


Ala Lys Val Leu Thr Gly Gln Val His Glu Leu Lys Asp Leu Arg Glu 
    210                 215                 220                 


Tyr Asp Thr Ala Glu Ala Gln Ser Leu Lys Pro Ser Lys Ala Glu 
225                 230                 235                 


<210>  2629
<211>  372
<212>  PRT
<213>  Homo Sapiens

<400>  2629

Met Pro Pro Pro Gln Gln Gly Pro Cys Gly His His Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ala Leu Leu Leu Pro Ser Leu Pro Leu Thr Arg Ala Pro Val Pro 
            20                  25                  30          


Pro Gly Pro Ala Ala Ala Leu Leu Gln Ala Leu Gly Leu Arg Asp Glu 
        35                  40                  45              


Pro Gln Gly Ala Pro Arg Leu Arg Pro Val Pro Pro Val Met Trp Arg 
    50                  55                  60                  


Leu Phe Arg Arg Arg Asp Pro Gln Glu Thr Arg Ser Gly Ser Arg Arg 
65                  70                  75                  80  


Thr Ser Pro Gly Val Thr Leu Gln Pro Cys His Val Glu Glu Leu Gly 
                85                  90                  95      


Val Ala Gly Asn Ile Val Arg His Ile Pro Asp Arg Gly Ala Pro Thr 
            100                 105                 110         


Arg Ala Ser Glu Pro Ala Ser Ala Ala Gly His Cys Pro Glu Trp Thr 
        115                 120                 125             


Val Val Phe Asp Leu Ser Ala Val Glu Pro Ala Glu Arg Pro Ser Arg 
    130                 135                 140                 


Ala Arg Leu Glu Leu Arg Phe Ala Ala Ala Ala Ala Ala Ala Pro Glu 
145                 150                 155                 160 


Gly Gly Trp Glu Leu Ser Val Ala Gln Ala Gly Gln Gly Ala Gly Ala 
                165                 170                 175     


Asp Pro Gly Pro Val Leu Leu Arg Gln Leu Val Pro Ala Leu Gly Pro 
            180                 185                 190         


Pro Val Arg Ala Glu Leu Leu Gly Ala Ala Trp Ala Arg Asn Ala Ser 
        195                 200                 205             


Trp Pro Arg Ser Leu Arg Leu Ala Leu Ala Leu Arg Pro Arg Ala Pro 
    210                 215                 220                 


Ala Ala Cys Ala Arg Leu Ala Glu Ala Ser Leu Leu Leu Val Thr Leu 
225                 230                 235                 240 


Asp Pro Arg Leu Cys His Pro Leu Ala Arg Pro Arg Arg Asp Ala Glu 
                245                 250                 255     


Pro Val Leu Gly Gly Gly Pro Gly Gly Ala Cys Arg Ala Arg Arg Leu 
            260                 265                 270         


Tyr Val Ser Phe Arg Glu Val Gly Trp His Arg Trp Val Ile Ala Pro 
        275                 280                 285             


Arg Gly Phe Leu Ala Asn Tyr Cys Gln Gly Gln Cys Ala Leu Pro Val 
    290                 295                 300                 


Ala Leu Ser Gly Ser Gly Gly Pro Pro Ala Leu Asn His Ala Val Leu 
305                 310                 315                 320 


Arg Ala Leu Met His Ala Ala Ala Pro Gly Ala Ala Asp Leu Pro Cys 
                325                 330                 335     


Cys Val Pro Ala Arg Leu Ser Pro Ile Ser Val Leu Phe Phe Asp Asn 
            340                 345                 350         


Ser Asp Asn Val Val Leu Arg Gln Tyr Glu Asp Met Val Val Asp Glu 
        355                 360                 365             


Cys Gly Cys Arg 
    370         


<210>  2630
<211>  216
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2630

Xaa Ala Ala Ala Tyr Leu Leu Gln Gly Ser Phe Tyr Gly His Ser Ile 
1               5                   10                  15      


Tyr Ala Thr Leu Tyr Met Asp Thr Trp Arg Lys Asp Ser Val Val Met 
            20                  25                  30          


Leu Leu His His Val Val Thr Leu Ile Leu Ile Val Ser Ser Tyr Ala 
        35                  40                  45              


Phe Arg Tyr His Asn Val Gly Ile Leu Val Leu Phe Leu His Asp Ile 
    50                  55                  60                  


Ser Asp Val Gln Leu Glu Phe Thr Lys Leu Asn Ile Tyr Phe Lys Ser 
65                  70                  75                  80  


Arg Gly Gly Ser Tyr His Arg Leu His Ala Leu Ala Ala Asp Leu Gly 
                85                  90                  95      


Cys Leu Ser Phe Gly Phe Ser Trp Phe Trp Phe Arg Leu Tyr Trp Phe 
            100                 105                 110         


Pro Leu Lys Val Leu Tyr Ala Thr Ser His Cys Ser Leu Arg Thr Val 
        115                 120                 125             


Pro Asp Ile Pro Phe Tyr Phe Phe Phe Asn Ala Leu Leu Leu Leu Leu 
    130                 135                 140                 


Thr Leu Met Asn Leu Tyr Trp Phe Leu Tyr Ile Val Ala Phe Ala Ala 
145                 150                 155                 160 


Lys Val Leu Thr Gly Gln Val His Glu Leu Lys Asp Leu Arg Glu Tyr 
                165                 170                 175     


Asp Thr Ala Glu Ala Gln Ser Leu Lys Pro Ser Lys Ala Glu Glu Ala 
            180                 185                 190         


Val Ala Gln Ser Ser Val Thr Phe Phe Gly Thr Gly Gly Ala Arg Cys 
        195                 200                 205             


Arg His Leu Thr His Pro Gly Leu 
    210                 215     


<210>  2631
<211>  44
<212>  PRT
<213>  Homo Sapiens

<400>  2631

Glu Arg Asn Phe His Thr Val Pro Tyr Met Val Gly Ile Asn Lys Gln 
1               5                   10                  15      


Glu Phe Gly Trp Leu Ile Pro Met Met Leu Glu His Pro Pro Thr Cys 
            20                  25                  30          


Met Ser Phe Ser Thr Val Gln Ala Ser His Gln Thr 
        35                  40                  


<210>  2632
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  2632

Lys Glu Leu Ile Pro Glu Ala Thr Glu Lys Tyr Leu Gly Gly Thr Asp 
1               5                   10                  15      


Asp Thr Val Lys Lys Lys Asp Leu Phe Leu Asp Leu Ile Ala Asp Val 
            20                  25                  30          


Met Phe Gly Val Pro Ser Val Ile Val Ala Arg Asn His Arg Glu Gly 
        35                  40                  45              


Ala Ser Glu Glu Glu Ile Arg Leu Ser Lys Met Val Met Lys Phe Trp 
    50                  55                  60                  


Ala Asn Phe Ala Arg Asn Gly Asn Pro Asn Gly Glu Gly Leu Pro His 
65                  70                  75                  80  


Trp Pro Glu Tyr Asn Gln Lys Glu Gly Tyr Leu Gln Ile Gly Ala Asn 
                85                  90                  95      


Thr Gln Ala Ala Gln Lys Leu Lys Asp Lys Glu Val Ala Phe Trp Thr 
            100                 105                 110         


Asn Leu Phe Ala Lys Lys Ala Val Glu Lys Pro Pro Gln Thr Glu His 
        115                 120                 125             


Ile Glu Leu 
    130     


<210>  2633
<211>  568
<212>  PRT
<213>  Homo Sapiens

<400>  2633

Met Trp Leu Arg Ala Phe Ile Leu Ala Thr Leu Ser Ala Ser Ala Ala 
1               5                   10                  15      


Trp Ala Gly His Pro Ser Ser Pro Pro Val Val Asp Thr Val His Gly 
            20                  25                  30          


Lys Val Leu Gly Lys Phe Val Ser Leu Glu Gly Phe Ala Gln Pro Val 
        35                  40                  45              


Ala Ile Phe Leu Gly Ile Pro Phe Ala Lys Pro Pro Leu Gly Pro Leu 
    50                  55                  60                  


Arg Phe Thr Pro Pro Gln Pro Ala Glu Pro Trp Ser Phe Val Lys Asn 
65                  70                  75                  80  


Ala Thr Ser Tyr Pro Pro Met Cys Thr Gln Asp Pro Lys Ala Gly Gln 
                85                  90                  95      


Leu Leu Ser Glu Leu Phe Thr Asn Arg Lys Glu Asn Ile Pro Leu Lys 
            100                 105                 110         


Leu Ser Glu Asp Cys Leu Tyr Leu Asn Ile Tyr Thr Pro Ala Asp Leu 
        115                 120                 125             


Thr Lys Lys Asn Arg Leu Pro Val Met Val Trp Ile His Gly Gly Gly 
    130                 135                 140                 


Leu Met Val Gly Ala Ala Ser Thr Tyr Asp Gly Leu Ala Leu Ala Ala 
145                 150                 155                 160 


His Glu Asn Val Val Val Val Thr Ile Gln Tyr Arg Leu Gly Ile Trp 
                165                 170                 175     


Gly Phe Phe Ser Thr Gly Asp Glu His Ser Arg Gly Asn Trp Gly His 
            180                 185                 190         


Leu Asp Gln Val Ala Ala Leu Arg Trp Val Gln Asp Asn Ile Ala Ser 
        195                 200                 205             


Phe Gly Gly Asn Pro Gly Ser Val Thr Ile Phe Gly Glu Ser Ala Gly 
    210                 215                 220                 


Gly Glu Ser Val Ser Val Leu Val Leu Ser Pro Leu Ala Lys Asn Leu 
225                 230                 235                 240 


Phe His Arg Ala Ile Ser Glu Ser Gly Val Ala Leu Thr Ser Val Leu 
                245                 250                 255     


Val Lys Lys Gly Asp Val Lys Pro Leu Ala Glu Gln Ile Ala Ile Thr 
            260                 265                 270         


Ala Gly Cys Lys Thr Thr Thr Ser Ala Val Met Val His Cys Leu Arg 
        275                 280                 285             


Gln Lys Thr Glu Glu Glu Leu Leu Glu Thr Thr Leu Lys Met Lys Phe 
    290                 295                 300                 


Leu Ser Leu Asp Leu Gln Gly Asp Pro Arg Glu Ser Gln Pro Leu Leu 
305                 310                 315                 320 


Gly Thr Val Ile Asp Gly Met Leu Leu Leu Lys Thr Pro Glu Glu Leu 
                325                 330                 335     


Gln Ala Glu Arg Asn Phe His Thr Val Pro Tyr Met Val Gly Ile Asn 
            340                 345                 350         


Lys Gln Glu Phe Gly Trp Leu Ile Pro Met Gln Leu Met Ser Tyr Pro 
        355                 360                 365             


Leu Ser Glu Gly Gln Leu Asp Gln Lys Thr Ala Met Ser Leu Leu Trp 
    370                 375                 380                 


Lys Ser Tyr Pro Leu Val Cys Ile Ala Lys Glu Leu Ile Pro Glu Ala 
385                 390                 395                 400 


Thr Glu Lys Tyr Leu Gly Gly Thr Asp Asp Thr Val Lys Lys Lys Asp 
                405                 410                 415     


Leu Phe Leu Asp Leu Ile Ala Asp Val Met Phe Gly Val Pro Ser Val 
            420                 425                 430         


Ile Val Ala Arg Asn His Arg Asp Ala Gly Ala Pro Thr Tyr Met Tyr 
        435                 440                 445             


Glu Phe Gln Tyr Arg Pro Ser Phe Ser Ser Asp Met Lys Pro Lys Thr 
    450                 455                 460                 


Val Ile Gly Asp His Gly Asp Glu Leu Phe Ser Val Phe Gly Ala Pro 
465                 470                 475                 480 


Phe Leu Lys Glu Gly Ala Ser Glu Glu Glu Ile Arg Leu Ser Lys Met 
                485                 490                 495     


Val Met Lys Phe Trp Ala Asn Phe Ala Arg Asn Gly Asn Pro Asn Gly 
            500                 505                 510         


Glu Gly Leu Pro His Trp Pro Glu Tyr Asn Gln Lys Glu Gly Tyr Leu 
        515                 520                 525             


Gln Ile Gly Ala Asn Thr Gln Ala Ala Gln Lys Leu Lys Asp Lys Glu 
    530                 535                 540                 


Val Ala Phe Trp Thr Asn Leu Phe Ala Lys Lys Ala Val Glu Lys Pro 
545                 550                 555                 560 


Pro Gln Thr Glu His Ile Glu Leu 
                565             


<210>  2634
<211>  567
<212>  PRT
<213>  Homo Sapiens

<400>  2634

Met Trp Leu Arg Ala Phe Ile Leu Ala Thr Leu Ser Ala Ser Ala Ala 
1               5                   10                  15      


Trp Gly His Pro Ser Ser Pro Pro Val Val Asp Thr Val His Gly Lys 
            20                  25                  30          


Val Leu Gly Lys Phe Val Ser Leu Glu Gly Phe Ala Gln Pro Val Ala 
        35                  40                  45              


Ile Phe Leu Gly Ile Pro Phe Ala Lys Pro Pro Leu Gly Pro Leu Arg 
    50                  55                  60                  


Phe Thr Pro Pro Gln Pro Ala Glu Pro Trp Ser Phe Val Lys Asn Ala 
65                  70                  75                  80  


Thr Ser Tyr Pro Pro Met Cys Thr Gln Asp Pro Lys Ala Gly Gln Leu 
                85                  90                  95      


Leu Ser Glu Leu Phe Thr Asn Arg Lys Glu Asn Ile Pro Leu Lys Leu 
            100                 105                 110         


Ser Glu Asp Cys Leu Tyr Leu Asn Ile Tyr Thr Pro Ala Asp Leu Thr 
        115                 120                 125             


Lys Lys Asn Arg Leu Pro Val Met Val Trp Ile His Gly Gly Gly Leu 
    130                 135                 140                 


Met Val Gly Ala Ala Ser Thr Tyr Asp Gly Leu Ala Leu Ala Ala His 
145                 150                 155                 160 


Glu Asn Val Val Val Val Thr Ile Gln Tyr Arg Leu Gly Ile Trp Gly 
                165                 170                 175     


Phe Phe Ser Thr Gly Asp Glu His Ser Arg Gly Asn Trp Gly His Leu 
            180                 185                 190         


Asp Gln Val Ala Ala Leu Arg Trp Val Gln Asp Asn Ile Ala Ser Phe 
        195                 200                 205             


Gly Gly Asn Pro Gly Ser Val Thr Ile Phe Gly Glu Ser Ala Gly Gly 
    210                 215                 220                 


Glu Ser Val Ser Val Leu Val Leu Ser Pro Leu Ala Lys Asn Leu Phe 
225                 230                 235                 240 


His Arg Ala Ile Ser Glu Ser Gly Val Ala Leu Thr Ser Val Leu Val 
                245                 250                 255     


Lys Lys Gly Asp Val Lys Pro Leu Ala Glu Gln Ile Ala Ile Thr Ala 
            260                 265                 270         


Gly Cys Lys Thr Thr Thr Ser Ala Val Met Val His Cys Leu Arg Gln 
        275                 280                 285             


Lys Thr Glu Glu Glu Leu Leu Glu Thr Thr Leu Lys Met Lys Phe Leu 
    290                 295                 300                 


Ser Leu Asp Leu Gln Gly Asp Pro Arg Glu Ser Gln Pro Leu Leu Gly 
305                 310                 315                 320 


Thr Val Ile Asp Gly Met Leu Leu Leu Lys Thr Pro Glu Glu Leu Gln 
                325                 330                 335     


Ala Glu Arg Asn Phe His Thr Val Pro Tyr Met Val Gly Ile Asn Lys 
            340                 345                 350         


Gln Glu Phe Gly Trp Leu Ile Pro Met Gln Leu Met Ser Tyr Pro Leu 
        355                 360                 365             


Ser Glu Gly Gln Leu Asp Gln Lys Thr Ala Met Ser Leu Leu Trp Lys 
    370                 375                 380                 


Ser Tyr Pro Leu Val Cys Ile Ala Lys Glu Leu Ile Pro Glu Ala Thr 
385                 390                 395                 400 


Glu Lys Tyr Leu Gly Gly Thr Asp Asp Thr Val Lys Lys Lys Asp Leu 
                405                 410                 415     


Phe Leu Asp Leu Ile Ala Asp Val Met Phe Gly Val Pro Ser Val Ile 
            420                 425                 430         


Val Ala Arg Asn His Arg Asp Ala Gly Ala Pro Thr Tyr Met Tyr Glu 
        435                 440                 445             


Phe Gln Tyr Arg Pro Ser Phe Ser Ser Asp Met Lys Pro Lys Thr Val 
    450                 455                 460                 


Ile Gly Asp His Gly Asp Glu Leu Phe Ser Val Phe Gly Ala Pro Phe 
465                 470                 475                 480 


Leu Lys Glu Gly Ala Ser Glu Glu Glu Ile Arg Leu Ser Lys Met Val 
                485                 490                 495     


Met Lys Phe Trp Ala Asn Phe Ala Arg Asn Gly Asn Pro Asn Gly Glu 
            500                 505                 510         


Gly Leu Pro His Trp Pro Glu Tyr Asn Gln Lys Glu Gly Tyr Leu Gln 
        515                 520                 525             


Ile Gly Ala Asn Thr Gln Ala Ala Gln Lys Leu Lys Asp Lys Glu Val 
    530                 535                 540                 


Ala Phe Trp Thr Asn Leu Phe Ala Lys Lys Ala Val Glu Lys Pro Pro 
545                 550                 555                 560 


Gln Thr Glu His Ile Glu Leu 
                565         


<210>  2635
<211>  566
<212>  PRT
<213>  Homo Sapiens

<400>  2635

Met Trp Leu Arg Ala Phe Ile Leu Ala Thr Leu Ser Ala Ser Ala Ala 
1               5                   10                  15      


Trp Gly His Pro Ser Ser Pro Pro Val Val Asp Thr Val His Gly Lys 
            20                  25                  30          


Val Leu Gly Lys Phe Val Ser Leu Glu Gly Phe Ala Gln Pro Val Ala 
        35                  40                  45              


Ile Phe Leu Gly Ile Pro Phe Ala Lys Pro Pro Leu Gly Pro Leu Arg 
    50                  55                  60                  


Phe Thr Pro Pro Gln Pro Ala Glu Pro Trp Ser Phe Val Lys Asn Ala 
65                  70                  75                  80  


Thr Ser Tyr Pro Pro Met Cys Thr Gln Asp Pro Lys Ala Gly Gln Leu 
                85                  90                  95      


Leu Ser Glu Leu Phe Thr Asn Arg Lys Glu Asn Ile Pro Leu Lys Leu 
            100                 105                 110         


Ser Glu Asp Cys Leu Tyr Leu Asn Ile Tyr Thr Pro Ala Asp Leu Thr 
        115                 120                 125             


Lys Lys Asn Arg Leu Pro Val Met Val Trp Ile His Gly Gly Gly Leu 
    130                 135                 140                 


Met Val Gly Ala Ala Ser Thr Tyr Asp Gly Leu Ala Leu Ala Ala His 
145                 150                 155                 160 


Glu Asn Val Val Val Val Thr Ile Gln Tyr Arg Leu Gly Ile Trp Gly 
                165                 170                 175     


Phe Phe Ser Thr Gly Asp Glu His Ser Arg Gly Asn Trp Gly His Leu 
            180                 185                 190         


Asp Gln Val Ala Ala Leu Arg Trp Val Gln Asp Asn Ile Ala Ser Phe 
        195                 200                 205             


Gly Gly Asn Pro Gly Ser Val Thr Ile Phe Gly Glu Ser Ala Gly Gly 
    210                 215                 220                 


Glu Ser Val Ser Val Leu Val Leu Ser Pro Leu Ala Lys Asn Leu Phe 
225                 230                 235                 240 


His Arg Ala Ile Ser Glu Ser Gly Val Ala Leu Thr Ser Val Leu Val 
                245                 250                 255     


Lys Lys Gly Asp Val Lys Pro Leu Ala Glu Gln Ile Ala Ile Thr Ala 
            260                 265                 270         


Gly Cys Lys Thr Thr Thr Ser Ala Val Met Val His Cys Leu Arg Gln 
        275                 280                 285             


Lys Thr Glu Glu Glu Leu Leu Glu Thr Thr Leu Lys Met Lys Phe Leu 
    290                 295                 300                 


Ser Leu Asp Leu Gln Gly Asp Pro Arg Glu Ser Gln Pro Leu Leu Gly 
305                 310                 315                 320 


Thr Val Ile Asp Gly Met Leu Leu Leu Lys Thr Pro Glu Glu Leu Gln 
                325                 330                 335     


Ala Glu Arg Asn Phe His Thr Val Pro Tyr Met Val Gly Ile Asn Lys 
            340                 345                 350         


Gln Glu Phe Gly Trp Leu Ile Pro Met Leu Met Ser Tyr Pro Leu Ser 
        355                 360                 365             


Glu Gly Gln Leu Asp Gln Lys Thr Ala Met Ser Leu Leu Trp Lys Ser 
    370                 375                 380                 


Tyr Pro Leu Val Cys Ile Ala Lys Glu Leu Ile Pro Glu Ala Thr Glu 
385                 390                 395                 400 


Lys Tyr Leu Gly Gly Thr Asp Asp Thr Val Lys Lys Lys Asp Leu Phe 
                405                 410                 415     


Leu Asp Leu Ile Ala Asp Val Met Phe Gly Val Pro Ser Val Ile Val 
            420                 425                 430         


Ala Arg Asn His Arg Asp Ala Gly Ala Pro Thr Tyr Met Tyr Glu Phe 
        435                 440                 445             


Gln Tyr Arg Pro Ser Phe Ser Ser Asp Met Lys Pro Lys Thr Val Ile 
    450                 455                 460                 


Gly Asp His Gly Asp Glu Leu Phe Ser Val Phe Gly Ala Pro Phe Leu 
465                 470                 475                 480 


Lys Glu Gly Ala Ser Glu Glu Glu Ile Arg Leu Ser Lys Met Val Met 
                485                 490                 495     


Lys Phe Trp Ala Asn Phe Ala Arg Asn Gly Asn Pro Asn Gly Glu Gly 
            500                 505                 510         


Leu Pro His Trp Pro Glu Tyr Asn Gln Lys Glu Gly Tyr Leu Gln Ile 
        515                 520                 525             


Gly Ala Asn Thr Gln Ala Ala Gln Lys Leu Lys Asp Lys Glu Val Ala 
    530                 535                 540                 


Phe Trp Thr Asn Leu Phe Ala Lys Lys Ala Val Glu Lys Pro Pro Gln 
545                 550                 555                 560 


Thr Glu His Ile Glu Leu 
                565     


<210>  2636
<211>  84
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2636

Xaa Arg Gln Lys Thr Glu Glu Glu Leu Leu Glu Thr Thr Leu Lys Met 
1               5                   10                  15      


Lys Phe Leu Ser Leu Asp Leu Gln Gly Asp Pro Arg Glu Ser Gln Pro 
            20                  25                  30          


Leu Leu Gly Thr Val Ile Asp Gly Met Leu Leu Leu Lys Thr Pro Glu 
        35                  40                  45              


Glu Leu Gln Ala Glu Arg Asn Phe His Thr Val Pro Tyr Met Val Gly 
    50                  55                  60                  


Ile Asn Lys Gln Glu Phe Gly Trp Leu Ile Pro Met Gly Thr Ala Asp 
65                  70                  75                  80  


Ile Ser Val Tyr 
                


<210>  2637
<211>  210
<212>  PRT
<213>  Homo Sapiens

<400>  2637

Met Glu Gln Met Ser Arg Glu Asp Met Leu Ala Ile Ser Thr Pro Val 
1               5                   10                  15      


Leu Thr Ser Leu Asp Val Pro Pro Glu Met Met Pro Thr Val Ile Asp 
            20                  25                  30          


Glu Tyr Leu Gly Ser Asn Ser Asp Ala Gln Ala Lys Cys Gln Ala Phe 
        35                  40                  45              


Gln Glu Phe Met Gly Asp Val Phe Ile Asn Val Pro Thr Val Ser Phe 
    50                  55                  60                  


Ser Arg Tyr Leu Arg Asp Ser Gly Ser Pro Val Phe Phe Tyr Glu Phe 
65                  70                  75                  80  


Gln His Arg Pro Ser Ser Phe Ala Lys Ile Lys Pro Ala Trp Val Lys 
                85                  90                  95      


Ala Asp His Gly Ala Glu Gly Ala Phe Val Phe Gly Gly Pro Phe Leu 
            100                 105                 110         


Met Asp Glu Ser Ser Arg Leu Ala Phe Pro Glu Ala Thr Glu Glu Glu 
        115                 120                 125             


Lys Gln Leu Ser Leu Thr Met Met Ala Gln Trp Thr His Phe Ala Arg 
    130                 135                 140                 


Thr Gly Asp Pro Asn Ser Lys Ala Leu Pro Pro Trp Pro Gln Phe Asn 
145                 150                 155                 160 


Gln Ala Glu Gln Tyr Leu Glu Ile Asn Pro Val Pro Arg Ala Gly Gln 
                165                 170                 175     


Lys Phe Arg Glu Ala Trp Met Gln Phe Trp Ser Glu Thr Leu Pro Ser 
            180                 185                 190         


Lys Ile Gln Gln Trp His Gln Lys Gln Lys Asn Arg Lys Ala Gln Glu 
        195                 200                 205             


Asp Leu 
    210 


<210>  2638
<211>  571
<212>  PRT
<213>  Homo Sapiens

<400>  2638

Met Glu Arg Ala Val Arg Val Glu Ser Gly Val Leu Val Gly Val Val 
1               5                   10                  15      


Cys Leu Leu Leu Ala Cys Pro Ala Thr Ala Thr Gly Pro Glu Val Ala 
            20                  25                  30          


Gln Pro Glu Val Asp Thr Thr Leu Gly Arg Val Arg Gly Arg Gln Val 
        35                  40                  45              


Gly Val Lys Gly Thr Asp Arg Leu Val Asn Val Phe Leu Gly Ile Pro 
    50                  55                  60                  


Phe Ala Gln Pro Pro Leu Gly Pro Asp Arg Phe Ser Ala Pro His Pro 
65                  70                  75                  80  


Ala Gln Pro Trp Glu Gly Val Arg Asp Ala Ser Thr Ala Pro Pro Met 
                85                  90                  95      


Cys Leu Gln Asp Val Glu Ser Met Asn Ser Ser Arg Phe Val Leu Asn 
            100                 105                 110         


Gly Lys Gln Gln Ile Phe Ser Val Ser Glu Asp Cys Leu Val Leu Asn 
        115                 120                 125             


Val Tyr Ser Pro Ala Glu Val Pro Ala Gly Ser Gly Arg Pro Val Met 
    130                 135                 140                 


Val Trp Val His Gly Gly Ala Leu Ile Thr Gly Ala Ala Thr Ser Tyr 
145                 150                 155                 160 


Asp Gly Ser Ala Leu Ala Ala Tyr Gly Asp Val Val Val Val Thr Val 
                165                 170                 175     


Gln Tyr Arg Leu Gly Val Leu Gly Phe Phe Ser Thr Gly Asp Glu His 
            180                 185                 190         


Ala Pro Gly Asn Gln Gly Phe Leu Asp Val Val Ala Ala Leu Arg Trp 
        195                 200                 205             


Val Gln Glu Asn Ile Ala Pro Phe Gly Gly Asp Leu Asn Cys Val Thr 
    210                 215                 220                 


Val Phe Gly Gly Ser Ala Gly Gly Ser Ile Ile Ser Gly Leu Val Leu 
225                 230                 235                 240 


Ser Pro Val Ala Ala Gly Leu Phe His Arg Ala Ile Thr Gln Ser Gly 
                245                 250                 255     


Val Ile Thr Thr Pro Gly Ile Ile Asp Ser His Pro Trp Pro Leu Ala 
            260                 265                 270         


Gln Lys Ile Ala Asn Thr Leu Ala Cys Ser Ser Ser Ser Pro Ala Glu 
        275                 280                 285             


Met Val Gln Cys Leu Gln Gln Lys Glu Gly Glu Glu Leu Val Leu Ser 
    290                 295                 300                 


Lys Lys Leu Lys Asn Thr Ile Tyr Pro Leu Thr Val Asp Gly Thr Val 
305                 310                 315                 320 


Phe Pro Lys Ser Pro Lys Glu Leu Leu Lys Glu Lys Pro Phe His Ser 
                325                 330                 335     


Val Pro Phe Leu Met Gly Val Asn Asn His Glu Phe Ser Trp Leu Ile 
            340                 345                 350         


Pro Arg Gly Trp Gly Leu Leu Asp Thr Met Glu Gln Met Ser Arg Glu 
        355                 360                 365             


Asp Met Leu Ala Ile Ser Thr Pro Val Leu Thr Ser Leu Asp Val Pro 
    370                 375                 380                 


Pro Glu Met Met Pro Thr Val Ile Asp Glu Tyr Leu Gly Ser Asn Ser 
385                 390                 395                 400 


Asp Ala Gln Ala Lys Cys Gln Ala Phe Gln Glu Phe Met Gly Asp Val 
                405                 410                 415     


Phe Ile Asn Val Pro Thr Val Ser Phe Ser Arg Tyr Leu Arg Asp Ser 
            420                 425                 430         


Gly Ser Pro Val Phe Phe Tyr Glu Phe Gln His Arg Pro Ser Ser Phe 
        435                 440                 445             


Ala Lys Ile Lys Pro Ala Trp Val Lys Ala Asp His Gly Ala Glu Gly 
    450                 455                 460                 


Ala Phe Val Phe Gly Gly Pro Phe Leu Met Asp Glu Ser Ser Arg Leu 
465                 470                 475                 480 


Ala Phe Pro Glu Ala Thr Glu Glu Glu Lys Gln Leu Ser Leu Thr Met 
                485                 490                 495     


Met Ala Gln Trp Thr His Phe Ala Arg Thr Gly Asp Pro Asn Ser Lys 
            500                 505                 510         


Ala Leu Pro Pro Trp Pro Gln Phe Asn Gln Ala Glu Gln Tyr Leu Glu 
        515                 520                 525             


Ile Asn Pro Val Pro Arg Ala Gly Gln Lys Phe Arg Glu Ala Trp Met 
    530                 535                 540                 


Gln Phe Trp Ser Glu Thr Leu Pro Ser Lys Ile Gln Gln Trp His Gln 
545                 550                 555                 560 


Lys Gln Lys Asn Arg Lys Ala Gln Glu Asp Leu 
                565                 570     


<210>  2639
<211>  568
<212>  PRT
<213>  Homo Sapiens

<400>  2639

Met Glu Arg Ala Val Arg Val Glu Ser Gly Val Leu Val Gly Val Val 
1               5                   10                  15      


Cys Leu Leu Leu Ala Cys Pro Ala Thr Ala Thr Gly Pro Glu Val Ala 
            20                  25                  30          


Gln Pro Glu Val Asp Thr Thr Leu Gly Arg Val Arg Gly Arg Gln Val 
        35                  40                  45              


Gly Val Lys Gly Thr Asp Arg Leu Val Asn Val Phe Leu Gly Ile Pro 
    50                  55                  60                  


Phe Ala Gln Pro Pro Leu Gly Pro Asp Arg Phe Ser Ala Pro His Pro 
65                  70                  75                  80  


Ala Gln Pro Trp Glu Gly Val Arg Asp Ala Ser Thr Ala Pro Pro Met 
                85                  90                  95      


Cys Leu Gln Asp Val Glu Ser Met Asn Ser Ser Arg Phe Val Leu Asn 
            100                 105                 110         


Gly Lys Gln Gln Ile Phe Ser Val Ser Glu Asp Cys Leu Val Leu Asn 
        115                 120                 125             


Val Tyr Ser Pro Ala Glu Val Pro Ala Gly Ser Gly Arg Pro Val Met 
    130                 135                 140                 


Val Trp Val His Gly Gly Ala Leu Ile Thr Gly Ala Ala Thr Ser Tyr 
145                 150                 155                 160 


Asp Gly Ser Ala Leu Ala Ala Tyr Gly Asp Val Val Val Val Thr Val 
                165                 170                 175     


Gln Tyr Arg Leu Gly Val Leu Gly Phe Phe Ser Thr Gly Asp Glu His 
            180                 185                 190         


Ala Pro Gly Asn Gln Gly Phe Leu Asp Val Val Ala Ala Leu Arg Trp 
        195                 200                 205             


Val Gln Glu Asn Ile Ala Pro Phe Gly Gly Asp Leu Asn Cys Val Thr 
    210                 215                 220                 


Val Phe Gly Gly Ser Ala Gly Gly Ser Ile Ile Ser Gly Leu Val Leu 
225                 230                 235                 240 


Ser Pro Val Ala Ala Gly Leu Phe His Arg Ala Ile Thr Gln Ser Gly 
                245                 250                 255     


Val Ile Thr Thr Pro Gly Ile Ile Asp Ser His Pro Trp Pro Leu Ala 
            260                 265                 270         


Gln Lys Ile Ala Asn Thr Leu Ala Cys Ser Ser Ser Ser Pro Ala Glu 
        275                 280                 285             


Met Val Gln Cys Leu Gln Gln Lys Glu Gly Glu Glu Leu Val Leu Ser 
    290                 295                 300                 


Lys Lys Leu Lys Asn Thr Ile Tyr Pro Leu Thr Val Asp Gly Thr Val 
305                 310                 315                 320 


Phe Pro Lys Ser Pro Lys Glu Leu Leu Lys Glu Lys Pro Phe His Ser 
                325                 330                 335     


Val Pro Phe Leu Met Gly Val Asn Asn His Glu Phe Ser Trp Leu Ile 
            340                 345                 350         


Pro Arg Gly Trp Gly Leu Leu Asp Thr Met Glu Gln Met Ser Arg Glu 
        355                 360                 365             


Asp Met Leu Ala Ile Ser Thr Pro Val Leu Thr Ser Leu Asp Val Pro 
    370                 375                 380                 


Pro Glu Met Met Pro Thr Val Ile Asp Glu Tyr Leu Gly Ser Asn Ser 
385                 390                 395                 400 


Asp Ala Gln Ala Lys Cys Gln Ala Phe Gln Glu Phe Met Gly Asp Val 
                405                 410                 415     


Phe Ile Asn Val Pro Thr Val Ser Phe Ser Arg Tyr Leu Arg Asp Ser 
            420                 425                 430         


Gly Ser Pro Val Phe Phe Tyr Glu Phe Gln His Arg Pro Ser Ser Phe 
        435                 440                 445             


Ala Lys Ile Lys Pro Ala Trp Val Lys Ala Asp His Gly Ala Glu Gly 
    450                 455                 460                 


Ala Phe Val Phe Gly Gly Pro Phe Leu Met Asp Glu Ser Ser Arg Leu 
465                 470                 475                 480 


Glu Ala Thr Glu Glu Glu Lys Gln Leu Ser Leu Thr Met Met Ala Gln 
                485                 490                 495     


Trp Thr His Phe Ala Arg Thr Gly Asp Pro Asn Ser Lys Ala Leu Pro 
            500                 505                 510         


Pro Trp Pro Gln Phe Asn Gln Ala Glu Gln Tyr Leu Glu Ile Asn Pro 
        515                 520                 525             


Val Pro Arg Ala Gly Gln Lys Phe Arg Glu Ala Trp Met Gln Phe Trp 
    530                 535                 540                 


Ser Glu Thr Leu Pro Ser Lys Ile Gln Gln Trp His Gln Lys Gln Lys 
545                 550                 555                 560 


Asn Arg Lys Ala Gln Glu Asp Leu 
                565             


<210>  2640
<211>  379
<212>  PRT
<213>  Homo Sapiens

<400>  2640

Met Glu Arg Ala Val Arg Val Glu Ser Gly Val Leu Val Gly Val Val 
1               5                   10                  15      


Cys Leu Leu Leu Ala Cys Pro Ala Thr Ala Thr Gly Pro Glu Val Ala 
            20                  25                  30          


Gln Pro Glu Val Asp Thr Thr Leu Gly Arg Val Arg Gly Arg Gln Val 
        35                  40                  45              


Gly Val Lys Gly Thr Asp Arg Leu Val Asn Val Phe Leu Gly Ile Pro 
    50                  55                  60                  


Phe Ala Gln Pro Pro Leu Gly Pro Asp Arg Phe Ser Ala Pro His Pro 
65                  70                  75                  80  


Ala Gln Pro Trp Glu Gly Val Arg Asp Ala Ser Thr Ala Pro Pro Met 
                85                  90                  95      


Cys Leu Gln Asp Val Glu Ser Met Asn Ser Ser Arg Phe Val Leu Asn 
            100                 105                 110         


Gly Lys Gln Gln Ile Phe Ser Val Ser Glu Asp Cys Leu Val Leu Asn 
        115                 120                 125             


Val Tyr Ser Pro Ala Glu Val Pro Ala Gly Ser Gly Arg Pro Val Met 
    130                 135                 140                 


Val Trp Val His Gly Gly Ala Leu Ile Thr Gly Ala Ala Thr Ser Tyr 
145                 150                 155                 160 


Asp Gly Ser Ala Leu Ala Ala Tyr Gly Asp Val Val Val Val Thr Val 
                165                 170                 175     


Gln Tyr Arg Leu Gly Val Leu Gly Phe Phe Ser Thr Gly Asp Glu His 
            180                 185                 190         


Ala Pro Gly Asn Gln Gly Phe Leu Asp Val Val Ala Ala Leu Arg Trp 
        195                 200                 205             


Val Gln Glu Asn Ile Ala Pro Phe Gly Gly Asp Leu Asn Cys Val Thr 
    210                 215                 220                 


Val Phe Gly Gly Ser Ala Gly Gly Ser Ile Ile Ser Gly Leu Val Leu 
225                 230                 235                 240 


Ser Pro Val Ala Ala Gly Leu Phe His Arg Ala Ile Thr Gln Ser Gly 
                245                 250                 255     


Val Ile Thr Thr Pro Gly Ile Ile Asp Ser His Pro Trp Pro Leu Ala 
            260                 265                 270         


Gln Lys Ile Ala Asn Thr Leu Ala Cys Ser Ser Ser Ser Pro Ala Glu 
        275                 280                 285             


Met Val Gln Cys Leu Gln Gln Lys Glu Gly Glu Glu Leu Val Leu Ser 
    290                 295                 300                 


Lys Lys Leu Lys Asn Thr Ile Tyr Pro Leu Thr Val Asp Gly Thr Val 
305                 310                 315                 320 


Phe Pro Lys Ser Pro Lys Glu Leu Leu Lys Glu Lys Pro Phe His Ser 
                325                 330                 335     


Val Pro Phe Leu Met Gly Val Asn Asn His Glu Phe Ser Trp Leu Ile 
            340                 345                 350         


Pro Arg Ile Leu Glu Ala Leu Ser Phe Ser Met Ser Ser Ser Ile Asp 
        355                 360                 365             


Pro Val Leu Leu Arg Arg Ser Asn Leu Pro Gly 
    370                 375                 


<210>  2641
<211>  40
<212>  PRT
<213>  Homo Sapiens

<400>  2641

Met Glu Arg Ala Val Arg Val Glu Ser Gly Val Leu Val Gly Val Val 
1               5                   10                  15      


Cys Leu Leu Leu Ala Cys Pro Ala Thr Ala Thr Gly Tyr Gln Asp Ala 
            20                  25                  30          


Val Trp Ala Arg Ser Cys Ser Ala 
        35                  40  


<210>  2642
<211>  454
<212>  PRT
<213>  Homo Sapiens

<400>  2642

Gly Lys Gln Met His Val Gly Lys Thr Pro Ile Gln Val Phe Leu Gly 
1               5                   10                  15      


Val Pro Phe Ser Arg Pro Pro Leu Gly Ile Leu Arg Phe Ala Pro Pro 
            20                  25                  30          


Glu Pro Pro Glu Pro Trp Lys Gly Ile Arg Asp Ala Thr Thr Tyr Pro 
        35                  40                  45              


Pro Gly Cys Leu Gln Glu Ser Trp Gly Gln Leu Ala Ser Met Tyr Val 
    50                  55                  60                  


Ser Thr Arg Glu Arg Tyr Lys Trp Leu Arg Phe Ser Glu Asp Cys Leu 
65                  70                  75                  80  


Tyr Leu Asn Val Tyr Ala Pro Ala Arg Ala Pro Gly Asp Pro Gln Leu 
                85                  90                  95      


Pro Val Met Val Trp Phe Pro Gly Gly Ala Phe Ile Val Gly Ala Ala 
            100                 105                 110         


Ser Ser Tyr Glu Gly Ser Asp Leu Ala Ala Arg Glu Lys Val Val Leu 
        115                 120                 125             


Val Phe Leu Gln His Arg Leu Gly Ile Phe Gly Phe Leu Ser Thr Asp 
    130                 135                 140                 


Asp Ser His Ala Arg Gly Asn Trp Gly Leu Leu Asp Gln Met Ala Ala 
145                 150                 155                 160 


Leu Arg Trp Val Gln Glu Asn Ile Ala Ala Phe Gly Gly Asp Pro Gly 
                165                 170                 175     


Asn Val Thr Leu Phe Gly Gln Ser Ala Gly Ala Met Ser Ile Ser Gly 
            180                 185                 190         


Leu Met Met Ser Pro Leu Ala Ser Gly Leu Phe His Arg Ala Ile Ser 
        195                 200                 205             


Gln Ser Gly Thr Ala Leu Phe Arg Leu Phe Ile Thr Ser Asn Pro Leu 
    210                 215                 220                 


Lys Val Ala Lys Lys Val Ala His Leu Ala Gly Cys Asn His Asn Ser 
225                 230                 235                 240 


Thr Gln Ile Leu Val Asn Cys Leu Arg Ala Leu Ser Gly Thr Lys Val 
                245                 250                 255     


Met Arg Val Ser Asn Lys Met Arg Phe Leu Gln Leu Asn Phe Gln Arg 
            260                 265                 270         


Asp Pro Glu Glu Ile Ile Trp Ser Met Ser Pro Val Val Asp Gly Val 
        275                 280                 285             


Val Ile Pro Asp Asp Pro Leu Val Leu Leu Thr Gln Gly Lys Val Ser 
    290                 295                 300                 


Ser Val Pro Tyr Leu Leu Gly Val Asn Asn Leu Glu Phe Asn Trp Leu 
305                 310                 315                 320 


Leu Pro Tyr Asn Ile Thr Lys Glu Gln Val Pro Leu Val Val Glu Glu 
                325                 330                 335     


Tyr Leu Asp Asn Val Asn Glu His Asp Trp Lys Met Leu Arg Asn Arg 
            340                 345                 350         


Met Met Asp Ile Val Gln Asp Ala Thr Phe Val Tyr Ala Thr Leu Gln 
        355                 360                 365             


Thr Ala His Tyr His Arg Gly Leu Ser Met Gly Lys Glu Lys Ala Leu 
    370                 375                 380                 


Ser Leu Gln Met Met Lys Tyr Trp Ala Asn Phe Ala Arg Thr Gly Asn 
385                 390                 395                 400 


Pro Asn Asp Gly Asn Leu Pro Cys Trp Pro Arg Tyr Asn Lys Asp Glu 
                405                 410                 415     


Lys Tyr Leu Gln Leu Asp Phe Thr Thr Arg Val Gly Met Lys Leu Lys 
            420                 425                 430         


Glu Lys Lys Met Ala Phe Trp Met Ser Leu Tyr Gln Ser Gln Arg Pro 
        435                 440                 445             


Glu Lys Gln Arg Gln Phe 
    450                 


<210>  2643
<211>  468
<212>  PRT
<213>  Homo Sapiens

<400>  2643

Met Arg Trp Ile Leu Cys Trp Ser Leu Thr Leu Cys Leu Met Ala Gln 
1               5                   10                  15      


Thr Ala Leu Gly Ala Leu His Thr Lys Arg Pro Gln Val Val Thr Lys 
            20                  25                  30          


Tyr Gly Thr Leu Gln Gly Lys Gln Met His Val Gly Lys Thr Pro Ile 
        35                  40                  45              


Gln Val Phe Leu Gly Val Pro Phe Ser Arg Pro Pro Leu Gly Ile Leu 
    50                  55                  60                  


Arg Phe Ala Pro Pro Glu Pro Pro Glu Pro Trp Lys Gly Ile Arg Asp 
65                  70                  75                  80  


Ala Thr Thr Tyr Pro Pro Gly Cys Leu Gln Glu Ser Trp Gly Gln Leu 
                85                  90                  95      


Ala Ser Met Tyr Val Ser Thr Arg Glu Arg Tyr Lys Trp Leu Arg Phe 
            100                 105                 110         


Ser Glu Asp Cys Leu Tyr Leu Asn Val Tyr Ala Pro Ala Arg Ala Pro 
        115                 120                 125             


Gly Asp Pro Gln Leu Pro Val Met Val Trp Phe Pro Gly Gly Ala Phe 
    130                 135                 140                 


Ile Val Gly Ala Ala Ser Ser Tyr Glu Gly Ser Asp Leu Ala Ala Arg 
145                 150                 155                 160 


Glu Lys Val Val Leu Val Phe Leu Gln His Arg Leu Gly Ile Phe Gly 
                165                 170                 175     


Phe Leu Ser Thr Asp Asp Ser His Ala Arg Gly Asn Trp Gly Leu Leu 
            180                 185                 190         


Asp Gln Met Ala Ala Leu Arg Trp Val Gln Glu Asn Ile Ala Ala Phe 
        195                 200                 205             


Gly Gly Asp Pro Gly Asn Val Thr Leu Phe Gly Gln Ser Ala Gly Ala 
    210                 215                 220                 


Met Ser Ile Ser Gly Leu Met Met Ser Pro Leu Ala Ser Gly Leu Phe 
225                 230                 235                 240 


His Arg Ala Ile Ser Gln Ser Gly Thr Ala Leu Phe Arg Leu Phe Ile 
                245                 250                 255     


Thr Ser Asn Pro Leu Lys Val Ala Lys Lys Val Ala His Leu Ala Gly 
            260                 265                 270         


Cys Asn His Asn Ser Thr Gln Ile Leu Val Asn Cys Leu Arg Ala Leu 
        275                 280                 285             


Ser Gly Thr Lys Val Met Arg Val Ser Asn Lys Met Arg Phe Leu Gln 
    290                 295                 300                 


Leu Asn Phe Gln Arg Asp Pro Glu Glu Ile Ile Trp Ser Met Ser Pro 
305                 310                 315                 320 


Val Val Asp Gly Val Val Ile Pro Asp Asp Pro Leu Val Leu Leu Thr 
                325                 330                 335     


Gln Gly Lys Val Ser Ser Val Pro Tyr Leu Leu Gly Val Asn Asn Leu 
            340                 345                 350         


Glu Phe Asn Trp Leu Leu Pro Tyr Ile Met Lys Phe Pro Leu Asn Arg 
        355                 360                 365             


Gln Ala Met Arg Lys Glu Thr Ile Thr Lys Met Leu Trp Ser Thr Arg 
    370                 375                 380                 


Thr Leu Leu Asn Ile Thr Lys Glu Gln Val Pro Leu Val Val Glu Glu 
385                 390                 395                 400 


Tyr Leu Asp Asn Val Asn Glu His Asp Trp Lys Met Leu Arg Asn Arg 
                405                 410                 415     


Met Met Asp Ile Val Gln Asp Ala Thr Phe Val Tyr Ala Thr Leu Gln 
            420                 425                 430         


Thr Ala His Tyr His Arg Glu Thr Pro Met Met Gly Ile Cys Pro Ala 
        435                 440                 445             


Gly His Ala Thr Thr Arg Met Lys Ser Thr Cys Ser Trp Ile Leu Pro 
    450                 455                 460                 


Gln Glu Trp Ala 
465             


<210>  2644
<211>  374
<212>  PRT
<213>  Homo Sapiens

<400>  2644

Met Tyr Val Ser Thr Arg Glu Arg Tyr Lys Trp Leu Arg Phe Ser Glu 
1               5                   10                  15      


Asp Cys Leu Tyr Leu Asn Val Tyr Ala Pro Ala Arg Ala Pro Gly Asp 
            20                  25                  30          


Pro Gln Leu Pro Val Met Val Trp Phe Pro Gly Gly Ala Phe Ile Val 
        35                  40                  45              


Gly Ala Ala Ser Ser Tyr Glu Gly Ser Asp Leu Ala Ala Arg Glu Lys 
    50                  55                  60                  


Val Val Leu Val Phe Leu Gln His Arg Leu Gly Ile Phe Gly Phe Leu 
65                  70                  75                  80  


Arg Trp Arg Gly Arg Thr Asp Asp Ser His Ala Arg Gly Asn Trp Gly 
                85                  90                  95      


Leu Leu Asp Gln Met Ala Ala Leu Arg Trp Val Gln Glu Asn Ile Ala 
            100                 105                 110         


Ala Phe Gly Gly Asp Pro Gly Asn Val Thr Leu Phe Gly Gln Ser Ala 
        115                 120                 125             


Gly Ala Met Ser Ile Ser Gly Leu Met Met Ser Pro Leu Ala Ser Gly 
    130                 135                 140                 


Leu Phe His Arg Ala Ile Ser Gln Ser Gly Thr Ala Leu Phe Arg Leu 
145                 150                 155                 160 


Phe Ile Thr Ser Asn Pro Leu Lys Val Ala Lys Lys Val Ala His Leu 
                165                 170                 175     


Ala Gly Cys Asn His Asn Ser Thr Gln Ile Leu Val Asn Cys Leu Arg 
            180                 185                 190         


Ala Leu Ser Gly Thr Lys Val Met Arg Val Ser Asn Lys Met Arg Phe 
        195                 200                 205             


Leu Gln Leu Asn Phe Gln Arg Asp Pro Glu Glu Ile Ile Trp Ser Met 
    210                 215                 220                 


Ser Pro Val Val Asp Gly Val Val Ile Pro Asp Asp Pro Leu Val Leu 
225                 230                 235                 240 


Leu Thr Gln Gly Lys Val Ser Ser Val Pro Tyr Leu Leu Gly Val Asn 
                245                 250                 255     


Asn Leu Glu Phe Asn Trp Leu Leu Pro Tyr Ile Met Lys Phe Pro Leu 
            260                 265                 270         


Asn Arg Gln Ala Met Arg Lys Glu Thr Ile Thr Lys Met Leu Trp Ser 
        275                 280                 285             


Thr Arg Thr Leu Leu Asn Ile Thr Lys Glu Gln Val Pro Leu Val Val 
    290                 295                 300                 


Glu Glu Tyr Leu Asp Asn Val Asn Glu His Asp Trp Lys Met Leu Arg 
305                 310                 315                 320 


Asn Arg Met Met Asp Ile Val Gln Asp Ala Thr Phe Val Tyr Ala Thr 
                325                 330                 335     


Leu Gln Thr Ala His Tyr His Arg Glu Thr Pro Met Met Gly Ile Cys 
            340                 345                 350         


Pro Ala Gly His Ala Thr Thr Arg Met Lys Ser Thr Cys Ser Trp Ile 
        355                 360                 365             


Leu Pro Gln Glu Trp Ala 
    370                 


<210>  2645
<211>  135
<212>  PRT
<213>  Homo Sapiens

<400>  2645

Met Tyr Val Ser Thr Arg Glu Arg Tyr Lys Trp Leu Arg Phe Ser Glu 
1               5                   10                  15      


Asp Cys Leu Tyr Leu Asn Val Tyr Ala Pro Ala Arg Ala Pro Gly Asp 
            20                  25                  30          


Pro Gln Leu Pro Val Met Val Trp Phe Pro Gly Gly Ala Phe Ile Val 
        35                  40                  45              


Gly Ala Ala Ser Ser Tyr Glu Gly Ser Asp Leu Ala Ala Arg Glu Lys 
    50                  55                  60                  


Val Val Leu Val Phe Leu Gln His Arg Leu Gly Ile Phe Gly Phe Leu 
65                  70                  75                  80  


Arg Trp Arg Gly Arg Tyr Pro Leu Gly Pro Gln Leu Trp Pro Glu Arg 
                85                  90                  95      


Arg Gly Leu Ala Arg Thr Thr Ala Thr Arg Ala Gly Thr Gly Gly Cys 
            100                 105                 110         


Trp Thr Arg Trp Arg Leu Cys Ala Gly Cys Arg Arg Thr Ser Gln Pro 
        115                 120                 125             


Ser Gly Glu Thr Gln Glu Met 
    130                 135 


<210>  2646
<211>  463
<212>  PRT
<213>  Homo Sapiens

<400>  2646

Met Tyr Val Ser Thr Arg Glu Arg Tyr Lys Trp Leu Arg Phe Ser Glu 
1               5                   10                  15      


Asp Cys Leu Tyr Leu Asn Val Tyr Ala Pro Ala Arg Ala Pro Gly Asp 
            20                  25                  30          


Pro Gln Leu Pro Val Met Val Trp Phe Pro Gly Gly Ala Phe Ile Val 
        35                  40                  45              


Gly Ala Ala Ser Ser Tyr Glu Gly Ser Asp Leu Ala Ala Arg Glu Lys 
    50                  55                  60                  


Val Val Leu Val Phe Leu Gln His Arg Leu Gly Ile Phe Gly Phe Leu 
65                  70                  75                  80  


Ser Thr Asp Asp Ser His Ala Arg Gly Asn Trp Gly Leu Leu Asp Gln 
                85                  90                  95      


Met Ala Ala Leu Arg Trp Val Gln Glu Asn Ile Ala Ala Phe Gly Gly 
            100                 105                 110         


Asp Pro Gly Asn Val Thr Leu Phe Gly Gln Ser Ala Gly Ala Met Ser 
        115                 120                 125             


Ile Ser Gly Leu Met Met Ser Pro Leu Ala Ser Gly Leu Phe His Arg 
    130                 135                 140                 


Ala Ile Ser Gln Ser Gly Thr Ala Leu Phe Arg Leu Phe Ile Thr Ser 
145                 150                 155                 160 


Asn Pro Leu Lys Val Ala Lys Lys Val Ala His Leu Ala Gly Cys Asn 
                165                 170                 175     


His Asn Ser Thr Gln Ile Leu Val Asn Cys Leu Arg Ala Leu Ser Gly 
            180                 185                 190         


Thr Lys Val Met Arg Val Ser Asn Lys Met Arg Phe Leu Gln Leu Asn 
        195                 200                 205             


Phe Gln Arg Asp Pro Glu Glu Ile Ile Trp Ser Met Ser Pro Val Val 
    210                 215                 220                 


Asp Gly Val Val Ile Pro Asp Asp Pro Leu Val Leu Leu Thr Gln Gly 
225                 230                 235                 240 


Lys Val Ser Ser Val Pro Tyr Leu Leu Gly Val Asn Asn Leu Glu Phe 
                245                 250                 255     


Asn Trp Leu Leu Pro Tyr Ile Met Lys Phe Pro Leu Asn Arg Gln Ala 
            260                 265                 270         


Met Arg Lys Glu Thr Ile Thr Lys Met Leu Trp Ser Thr Arg Thr Leu 
        275                 280                 285             


Leu Asn Ile Thr Lys Glu Gln Val Pro Leu Val Val Glu Glu Tyr Leu 
    290                 295                 300                 


Asp Asn Val Asn Glu His Asp Trp Lys Met Leu Arg Asn Arg Met Met 
305                 310                 315                 320 


Asp Ile Val Gln Asp Ala Thr Phe Val Tyr Ala Thr Leu Gln Thr Ala 
                325                 330                 335     


His Tyr His Arg Asp Ala Gly Leu Pro Val Tyr Leu Tyr Glu Phe Glu 
            340                 345                 350         


His His Ala Arg Gly Ile Ile Val Lys Pro Arg Thr Asp Gly Ala Asp 
        355                 360                 365             


His Gly Asp Glu Met Tyr Phe Leu Phe Gly Gly Pro Phe Ala Thr Gly 
    370                 375                 380                 


Leu Ser Met Gly Lys Glu Lys Ala Leu Ser Leu Gln Met Met Lys Tyr 
385                 390                 395                 400 


Trp Ala Asn Phe Ala Arg Thr Gly Asn Pro Asn Asp Gly Asn Leu Pro 
                405                 410                 415     


Cys Trp Pro Arg Tyr Asn Lys Asp Glu Lys Tyr Leu Gln Leu Asp Phe 
            420                 425                 430         


Thr Thr Arg Val Gly Met Lys Leu Lys Glu Lys Lys Met Ala Phe Trp 
        435                 440                 445             


Met Ser Leu Tyr Gln Ser Gln Arg Pro Glu Lys Gln Arg Gln Phe 
    450                 455                 460             


<210>  2647
<211>  177
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2647

Xaa Ala Leu His Thr Lys Arg Pro Gln Val Val Thr Lys Tyr Gly Thr 
1               5                   10                  15      


Leu Gln Gly Lys Gln Met His Val Gly Lys Thr Pro Ile Gln Val Phe 
            20                  25                  30          


Leu Gly Val Pro Phe Ser Arg Pro Pro Leu Gly Ile Leu Arg Phe Ala 
        35                  40                  45              


Pro Pro Glu Pro Pro Glu Pro Trp Lys Gly Ile Arg Asp Ala Thr Thr 
    50                  55                  60                  


Tyr Pro Pro Gly Trp Ser Leu Ala Leu Ser Pro Gly Trp Ser Ala Val 
65                  70                  75                  80  


Ala Arg Ser Arg Leu Thr Ala Thr Ser Ala Ser Arg Val Gln Ala Ser 
                85                  90                  95      


Leu Leu Pro Gln Pro Leu Ser Ile Trp Gly Tyr Arg Cys Leu Gln Glu 
            100                 105                 110         


Ser Trp Gly Gln Leu Ala Ser Met Tyr Val Ser Thr Arg Glu Arg Tyr 
        115                 120                 125             


Lys Trp Leu Arg Phe Ser Glu Asp Cys Leu Tyr Leu Asn Val Tyr Ala 
    130                 135                 140                 


Pro Ala Arg Ala Pro Gly Asp Pro Gln Leu Pro Val Ser Asp Gly Leu 
145                 150                 155                 160 


Val Pro Gly Arg Arg Leu His Arg Gly Arg Cys Phe Phe Val Arg Gly 
                165                 170                 175     


Leu 
    


<210>  2648
<211>  604
<212>  PRT
<213>  Homo Sapiens

<400>  2648

Met Ala Val Leu Val Cys Pro Ala Ser Cys His Gly Leu Lys Glu Phe 
1               5                   10                  15      


Arg Ile Arg Arg Gly Met Trp Arg Leu Cys Leu Val Tyr Tyr Phe Tyr 
            20                  25                  30          


Pro Ala Ser Ser Thr Leu Tyr Val Leu Arg Ile Asp Val Leu Asn Tyr 
        35                  40                  45              


Thr Ser Lys Asp Glu Gly Pro Ser Ala Glu Gly Pro Gln Arg Asn Thr 
    50                  55                  60                  


Arg Leu Gly Trp Ile Gln Gly Lys Gln Val Thr Val Leu Gly Ser Pro 
65                  70                  75                  80  


Val Pro Val Asn Val Phe Leu Gly Val Pro Phe Ala Ala Pro Pro Leu 
                85                  90                  95      


Gly Ser Leu Arg Phe Thr Asn Pro Gln Pro Ala Ser Pro Trp Asp Asn 
            100                 105                 110         


Leu Arg Glu Ala Thr Ser Tyr Pro Asn Leu Cys Leu Gln Asn Ser Glu 
        115                 120                 125             


Trp Leu Leu Leu Asp Gln His Met Leu Lys Val His Tyr Pro Lys Phe 
    130                 135                 140                 


Gly Val Ser Glu Asp Cys Leu Tyr Leu Asn Ile Tyr Ala Pro Ala His 
145                 150                 155                 160 


Ala Asp Thr Gly Ser Lys Leu Pro Val Leu Val Trp Phe Pro Gly Gly 
                165                 170                 175     


Ala Phe Lys Thr Gly Ser Ala Ser Ile Phe Asp Gly Ser Ala Leu Ala 
            180                 185                 190         


Ala Tyr Glu Asp Val Leu Val Val Val Val Gln Tyr Arg Leu Gly Ile 
        195                 200                 205             


Phe Gly Phe Phe Thr Thr Trp Asp Gln His Ala Pro Gly Asn Trp Ala 
    210                 215                 220                 


Phe Lys Asp Gln Val Ala Ala Leu Ser Trp Val Gln Lys Asn Ile Glu 
225                 230                 235                 240 


Phe Phe Gly Gly Asp Pro Ser Ser Val Thr Ile Phe Gly Glu Ser Ala 
                245                 250                 255     


Gly Ala Ile Ser Val Ser Ser Leu Ile Leu Ser Pro Met Ala Lys Gly 
            260                 265                 270         


Leu Phe His Lys Ala Ile Met Glu Ser Gly Val Ala Ile Ile Pro Tyr 
        275                 280                 285             


Leu Glu Ala His Asp Tyr Glu Lys Ser Glu Asp Leu Gln Val Val Ala 
    290                 295                 300                 


His Phe Cys Gly Asn Asn Ala Ser Asp Ser Glu Ala Leu Leu Arg Cys 
305                 310                 315                 320 


Leu Arg Thr Lys Pro Ser Lys Glu Leu Leu Thr Leu Ser Gln Lys Thr 
                325                 330                 335     


Lys Ser Phe Thr Arg Val Val Asp Gly Ala Phe Phe Pro Asn Glu Pro 
            340                 345                 350         


Leu Asp Leu Leu Ser Gln Lys Ala Phe Lys Ala Ile Pro Ser Ile Ile 
        355                 360                 365             


Gly Val Asn Asn His Glu Cys Gly Phe Leu Leu Pro Met Lys Glu Ala 
    370                 375                 380                 


Pro Glu Ile Leu Ser Gly Ser Asn Lys Ser Leu Ala Leu His Leu Ile 
385                 390                 395                 400 


Gln Asn Ile Leu His Ile Pro Pro Gln Tyr Leu His Leu Val Ala Asn 
                405                 410                 415     


Glu Tyr Phe His Asp Lys His Ser Leu Thr Glu Ile Arg Asp Ser Leu 
            420                 425                 430         


Leu Asp Leu Leu Gly Asp Val Phe Phe Val Val Pro Ala Leu Ile Thr 
        435                 440                 445             


Ala Arg Tyr His Arg Asp Ala Gly Ala Pro Val Tyr Phe Tyr Glu Phe 
    450                 455                 460                 


Arg His Arg Pro Gln Cys Phe Glu Asp Thr Lys Pro Ala Phe Val Lys 
465                 470                 475                 480 


Ala Asp His Ala Asp Glu Val Arg Phe Val Phe Gly Gly Ala Phe Leu 
                485                 490                 495     


Lys Gly Asp Ile Val Met Phe Glu Gly Ala Thr Glu Glu Glu Lys Leu 
            500                 505                 510         


Leu Ser Arg Lys Met Met Lys Tyr Trp Ala Thr Phe Ala Arg Thr Gly 
        515                 520                 525             


Asn Pro Asn Gly Asn Asp Leu Ser Leu Trp Pro Ala Tyr Asn Leu Thr 
    530                 535                 540                 


Glu Gln Tyr Leu Gln Leu Asp Leu Asn Met Ser Leu Gly Gln Arg Leu 
545                 550                 555                 560 


Lys Glu Pro Arg Val Asp Phe Trp Thr Ser Thr Ile Pro Leu Ile Leu 
                565                 570                 575     


Ser Ala Ser Asp Met Leu His Ser Pro Leu Ser Ser Leu Thr Phe Leu 
            580                 585                 590         


Ser Leu Leu Gln Pro Phe Phe Phe Phe Cys Ala Pro 
        595                 600                 


<210>  2649
<211>  355
<212>  PRT
<213>  Homo Sapiens

<400>  2649

Met Glu Asp Asp Leu Ser Trp Arg Ser Trp Ser Leu Leu Cys Met Glu 
1               5                   10                  15      


Ile Leu Ser Pro Met Ala Lys Gly Leu Phe His Lys Ala Ile Met Glu 
            20                  25                  30          


Ser Gly Val Ala Ile Ile Pro Tyr Leu Glu Ala His Asp Tyr Glu Lys 
        35                  40                  45              


Ser Glu Asp Leu Gln Val Val Ala His Phe Cys Gly Asn Asn Ala Ser 
    50                  55                  60                  


Asp Ser Glu Ala Leu Leu Arg Cys Leu Arg Thr Lys Pro Ser Lys Glu 
65                  70                  75                  80  


Leu Leu Thr Leu Ser Gln Lys Thr Lys Ser Phe Thr Arg Val Val Asp 
                85                  90                  95      


Gly Ala Phe Phe Pro Asn Glu Pro Leu Asp Leu Leu Ser Gln Lys Ala 
            100                 105                 110         


Phe Lys Ala Ile Pro Ser Ile Ile Gly Val Asn Asn His Glu Cys Gly 
        115                 120                 125             


Phe Leu Leu Pro Met Glu Ala Pro Glu Ile Leu Ser Gly Ser Asn Lys 
    130                 135                 140                 


Ser Leu Ala Leu His Leu Ile Gln Asn Ile Leu His Ile Pro Pro Gln 
145                 150                 155                 160 


Tyr Leu His Leu Val Ala Asn Glu Tyr Phe His Asp Lys His Ser Leu 
                165                 170                 175     


Thr Glu Ile Arg Asp Ser Leu Leu Asp Leu Leu Gly Asp Val Phe Phe 
            180                 185                 190         


Val Val Pro Ala Leu Ile Thr Ala Arg Tyr His Arg Asp Ala Gly Ala 
        195                 200                 205             


Pro Val Tyr Phe Tyr Glu Phe Arg His Arg Pro Gln Cys Phe Glu Asp 
    210                 215                 220                 


Thr Lys Pro Ala Phe Val Lys Ala Asp His Ala Asp Glu Val Arg Phe 
225                 230                 235                 240 


Val Phe Gly Gly Ala Phe Leu Lys Gly Asp Ile Val Met Phe Glu Gly 
                245                 250                 255     


Ala Thr Glu Glu Glu Lys Leu Leu Ser Arg Lys Met Met Lys Tyr Trp 
            260                 265                 270         


Ala Thr Phe Ala Arg Thr Gly Asn Pro Asn Gly Asn Asp Leu Ser Leu 
        275                 280                 285             


Trp Pro Ala Tyr Asn Leu Thr Glu Gln Tyr Leu Gln Leu Asp Leu Asn 
    290                 295                 300                 


Met Ser Leu Gly Gln Arg Leu Lys Glu Pro Arg Val Asp Phe Trp Thr 
305                 310                 315                 320 


Ser Thr Ile Pro Leu Ile Leu Ser Ala Ser Asp Met Leu His Ser Pro 
                325                 330                 335     


Leu Ser Ser Leu Thr Phe Leu Ser Leu Leu Gln Pro Phe Phe Phe Phe 
            340                 345                 350         


Cys Ala Pro 
        355 


<210>  2650
<211>  75
<212>  PRT
<213>  Homo Sapiens

<400>  2650

Met Leu Lys Val His Tyr Pro Lys Phe Gly Val Ser Glu Asp Cys Leu 
1               5                   10                  15      


Tyr Leu Asn Ile Tyr Ala Pro Ala His Ala Asp Thr Gly Ser Lys Leu 
            20                  25                  30          


Pro Val Leu Val Trp Phe Pro Gly Gly Ala Phe Lys Thr Gly Ser Ala 
        35                  40                  45              


Ser Ile Phe Asp Gly Ser Ala Leu Ala Ala Tyr Glu Asp Val Leu Val 
    50                  55                  60                  


Val Val Val Gln Tyr Arg Leu Gly Ile Phe Gly 
65                  70                  75  


<210>  2651
<211>  78
<212>  PRT
<213>  Homo Sapiens

<400>  2651

Met Leu Lys Val His Tyr Pro Lys Phe Gly Val Ser Glu Asp Cys Leu 
1               5                   10                  15      


Tyr Leu Asn Ile Tyr Ala Pro Ala His Ala Asp Thr Gly Ser Lys Leu 
            20                  25                  30          


Pro Val Leu Val Trp Phe Pro Gly Gly Ala Phe Lys Thr Gly Ser Ala 
        35                  40                  45              


Ser Ile Phe Asp Gly Ser Ala Leu Ala Ala Tyr Glu Asp Val Leu Val 
    50                  55                  60                  


Val Val Val Gln Tyr Arg Leu Gly Ile Phe Gly Phe Phe Thr 
65                  70                  75              


<210>  2652
<211>  469
<212>  PRT
<213>  Homo Sapiens

<400>  2652

Met Leu Lys Val His Tyr Pro Lys Phe Gly Val Ser Glu Asp Cys Leu 
1               5                   10                  15      


Tyr Leu Asn Ile Tyr Ala Pro Ala His Ala Asp Thr Gly Ser Lys Leu 
            20                  25                  30          


Pro Val Leu Val Trp Phe Pro Gly Gly Ala Phe Lys Thr Gly Ser Ala 
        35                  40                  45              


Ser Ile Phe Asp Gly Ser Ala Leu Ala Ala Tyr Glu Asp Val Leu Val 
    50                  55                  60                  


Val Val Val Gln Tyr Arg Leu Gly Ile Phe Gly Phe Phe Thr Thr Trp 
65                  70                  75                  80  


Asp Gln His Ala Pro Gly Asn Trp Ala Phe Lys Asp Gln Val Ala Ala 
                85                  90                  95      


Leu Ser Trp Val Gln Lys Asn Ile Glu Phe Phe Gly Gly Asp Pro Ser 
            100                 105                 110         


Ser Val Thr Ile Phe Gly Glu Ser Ala Gly Ala Ile Ser Val Ser Ser 
        115                 120                 125             


Leu Ile Leu Ser Pro Met Ala Lys Gly Leu Phe His Lys Ala Ile Met 
    130                 135                 140                 


Glu Ser Gly Val Ala Ile Ile Pro Tyr Leu Glu Ala His Asp Tyr Glu 
145                 150                 155                 160 


Lys Ser Glu Asp Leu Gln Val Val Ala His Phe Cys Gly Asn Asn Ala 
                165                 170                 175     


Ser Asp Ser Glu Ala Leu Leu Arg Cys Leu Arg Thr Lys Pro Ser Lys 
            180                 185                 190         


Glu Leu Leu Thr Leu Ser Gln Lys Thr Lys Ser Phe Thr Arg Val Val 
        195                 200                 205             


Asp Gly Ala Phe Phe Pro Asn Glu Pro Leu Asp Leu Leu Ser Gln Lys 
    210                 215                 220                 


Ala Phe Lys Ala Ile Pro Ser Ile Ile Gly Val Asn Asn His Glu Cys 
225                 230                 235                 240 


Gly Phe Leu Leu Pro Met Lys Glu Ala Pro Glu Ile Leu Ser Gly Ser 
                245                 250                 255     


Asn Lys Ser Leu Ala Leu His Leu Ile Gln Asn Ile Leu His Ile Pro 
            260                 265                 270         


Pro Gln Tyr Leu His Leu Val Ala Asn Glu Tyr Phe His Asp Lys His 
        275                 280                 285             


Ser Leu Thr Glu Ile Arg Asp Ser Leu Leu Asp Leu Leu Gly Asp Val 
    290                 295                 300                 


Phe Phe Val Val Pro Ala Leu Ile Thr Ala Arg Tyr His Arg Asp Ala 
305                 310                 315                 320 


Gly Ala Pro Val Tyr Phe Tyr Glu Phe Arg His Arg Pro Gln Cys Phe 
                325                 330                 335     


Glu Asp Thr Lys Pro Ala Phe Val Lys Ala Asp His Ala Asp Glu Val 
            340                 345                 350         


Arg Phe Val Phe Gly Gly Ala Phe Leu Lys Gly Asp Ile Val Met Phe 
        355                 360                 365             


Glu Gly Ala Thr Glu Glu Glu Lys Leu Leu Ser Arg Lys Met Met Lys 
    370                 375                 380                 


Tyr Trp Ala Thr Phe Ala Arg Thr Gly Asn Pro Asn Gly Asn Asp Leu 
385                 390                 395                 400 


Ser Leu Trp Pro Ala Tyr Asn Leu Thr Glu Gln Tyr Leu Gln Leu Asp 
                405                 410                 415     


Leu Asn Met Ser Leu Gly Gln Arg Leu Lys Glu Pro Arg Val Asp Phe 
            420                 425                 430         


Trp Thr Ser Thr Ile Pro Leu Ile Leu Ser Ala Ser Asp Met Leu His 
        435                 440                 445             


Ser Pro Leu Ser Ser Leu Thr Phe Leu Ser Leu Leu Gln Pro Phe Phe 
    450                 455                 460                 


Phe Phe Cys Ala Pro 
465                 


<210>  2653
<211>  575
<212>  PRT
<213>  Homo Sapiens

<400>  2653

Met Ser Gly Asn Trp Val His Pro Gly Gln Ile Leu Ile Trp Ala Ile 
1               5                   10                  15      


Trp Val Leu Ala Ala Pro Thr Lys Gly Pro Ser Ala Glu Gly Pro Gln 
            20                  25                  30          


Arg Asn Thr Arg Leu Gly Trp Ile Gln Gly Lys Gln Val Thr Val Leu 
        35                  40                  45              


Gly Ser Pro Val Pro Val Asn Val Phe Leu Gly Val Pro Phe Ala Ala 
    50                  55                  60                  


Pro Pro Leu Gly Ser Leu Arg Phe Thr Asn Pro Gln Pro Ala Ser Pro 
65                  70                  75                  80  


Trp Asp Asn Leu Arg Glu Ala Thr Ser Tyr Pro Asn Leu Cys Leu Gln 
                85                  90                  95      


Asn Ser Glu Trp Leu Leu Leu Asp Gln His Met Leu Lys Val His Tyr 
            100                 105                 110         


Pro Lys Phe Gly Val Ser Glu Asp Cys Leu Tyr Leu Asn Ile Tyr Ala 
        115                 120                 125             


Pro Ala His Ala Asp Thr Gly Ser Lys Leu Pro Val Leu Val Trp Phe 
    130                 135                 140                 


Pro Gly Gly Ala Phe Lys Thr Gly Ser Ala Ser Ile Phe Asp Gly Ser 
145                 150                 155                 160 


Ala Leu Ala Ala Tyr Glu Asp Val Leu Val Val Val Val Gln Tyr Arg 
                165                 170                 175     


Leu Gly Ile Phe Gly Phe Phe Thr Thr Trp Asp Gln His Ala Pro Gly 
            180                 185                 190         


Asn Trp Ala Phe Lys Asp Gln Val Ala Ala Leu Ser Trp Val Gln Lys 
        195                 200                 205             


Asn Ile Glu Phe Phe Gly Gly Asp Pro Ser Ser Val Thr Ile Phe Gly 
    210                 215                 220                 


Glu Ser Ala Gly Ala Ile Ser Val Ser Ser Leu Ile Leu Ser Pro Met 
225                 230                 235                 240 


Ala Lys Gly Leu Phe His Lys Ala Ile Met Glu Ser Gly Val Ala Ile 
                245                 250                 255     


Ile Pro Tyr Leu Glu Ala His Asp Tyr Glu Lys Ser Glu Asp Leu Gln 
            260                 265                 270         


Val Val Ala His Phe Cys Gly Asn Asn Ala Ser Asp Ser Glu Ala Leu 
        275                 280                 285             


Leu Arg Cys Leu Arg Thr Lys Pro Ser Lys Glu Leu Leu Thr Leu Ser 
    290                 295                 300                 


Gln Lys Thr Lys Ser Phe Thr Arg Val Val Asp Gly Ala Phe Phe Pro 
305                 310                 315                 320 


Asn Glu Pro Leu Asp Leu Leu Ser Gln Lys Ala Phe Lys Ala Ile Pro 
                325                 330                 335     


Ser Ile Ile Gly Val Asn Asn His Glu Cys Gly Phe Leu Leu Pro Met 
            340                 345                 350         


Lys Glu Ala Pro Glu Ile Leu Ser Gly Ser Asn Lys Ser Leu Ala Leu 
        355                 360                 365             


His Leu Ile Gln Asn Ile Leu His Ile Pro Pro Gln Tyr Leu His Leu 
    370                 375                 380                 


Val Ala Asn Glu Tyr Phe His Asp Lys His Ser Leu Thr Glu Ile Arg 
385                 390                 395                 400 


Asp Ser Leu Leu Asp Leu Leu Gly Asp Val Phe Phe Val Val Pro Ala 
                405                 410                 415     


Leu Ile Thr Ala Arg Tyr His Arg Asp Ala Gly Ala Pro Val Tyr Phe 
            420                 425                 430         


Tyr Glu Phe Arg His Arg Pro Gln Cys Phe Glu Asp Thr Lys Pro Ala 
        435                 440                 445             


Phe Val Lys Ala Asp His Ala Asp Glu Val Arg Phe Val Phe Gly Gly 
    450                 455                 460                 


Ala Phe Leu Lys Gly Asp Ile Val Met Phe Glu Gly Ala Thr Glu Glu 
465                 470                 475                 480 


Glu Lys Leu Leu Ser Arg Lys Met Met Lys Tyr Trp Ala Thr Phe Ala 
                485                 490                 495     


Arg Thr Gly Asn Pro Asn Gly Asn Asp Leu Ser Leu Trp Pro Ala Tyr 
            500                 505                 510         


Asn Leu Thr Glu Gln Tyr Leu Gln Leu Asp Leu Asn Met Ser Leu Gly 
        515                 520                 525             


Gln Arg Leu Lys Glu Pro Arg Val Asp Phe Trp Thr Ser Thr Ile Pro 
    530                 535                 540                 


Leu Ile Leu Ser Ala Ser Asp Met Leu His Ser Pro Leu Ser Ser Leu 
545                 550                 555                 560 


Thr Phe Leu Ser Leu Leu Gln Pro Phe Phe Phe Phe Cys Ala Pro 
                565                 570                 575 


<210>  2654
<211>  525
<212>  PRT
<213>  Homo Sapiens

<400>  2654

Met Ser Gly Asn Trp Val His Pro Gly Gln Ile Leu Ile Trp Ala Ile 
1               5                   10                  15      


Trp Val Leu Ala Ala Pro Thr Lys Gly Pro Ser Ala Glu Gly Pro Gln 
            20                  25                  30          


Arg Asn Thr Arg Leu Gly Trp Ile Gln Gly Lys Gln Val Thr Val Leu 
        35                  40                  45              


Gly Ser Pro Val Pro Val Asn Val Phe Leu Gly Val Pro Phe Ala Ala 
    50                  55                  60                  


Pro Pro Leu Gly Ser Leu Arg Phe Thr Asn Pro Gln Pro Ala Ser Pro 
65                  70                  75                  80  


Trp Asp Asn Leu Arg Glu Ala Thr Ser Tyr Pro Asn Leu Cys Leu Gln 
                85                  90                  95      


Asn Ser Glu Trp Leu Leu Leu Asp Gln His Met Leu Lys Val His Tyr 
            100                 105                 110         


Pro Lys Phe Gly Val Ser Glu Asp Cys Leu Tyr Leu Asn Ile Tyr Ala 
        115                 120                 125             


Pro Ala His Ala Asp Thr Gly Ser Lys Leu Pro Val Leu Val Trp Phe 
    130                 135                 140                 


Pro Gly Gly Ala Phe Lys Thr Gly Ser Ala Ser Ile Phe Asp Gly Ser 
145                 150                 155                 160 


Ala Leu Ala Ala Tyr Glu Asp Val Leu Val Val Val Val Gln Tyr Arg 
                165                 170                 175     


Leu Gly Ile Phe Gly Phe Phe Thr Thr Trp Asp Gln His Ala Pro Gly 
            180                 185                 190         


Asn Trp Ala Phe Lys Asp Gln Val Ala Ala Leu Ser Trp Val Gln Lys 
        195                 200                 205             


Asn Ile Glu Phe Phe Gly Gly Asp Pro Ser Ser Val Thr Ile Phe Gly 
    210                 215                 220                 


Glu Ser Ala Gly Ala Ile Ser Val Ser Ser Leu Ile Leu Ser Pro Met 
225                 230                 235                 240 


Ala Lys Gly Leu Phe His Lys Ala Ile Met Glu Ser Gly Val Ala Ile 
                245                 250                 255     


Ile Pro Tyr Leu Glu Ala His Asp Tyr Glu Lys Ser Glu Asp Leu Gln 
            260                 265                 270         


Val Val Ala His Phe Cys Gly Asn Asn Ala Ser Asp Ser Glu Ala Leu 
        275                 280                 285             


Leu Arg Cys Leu Arg Thr Lys Pro Ser Lys Glu Leu Leu Thr Leu Ser 
    290                 295                 300                 


Gln Lys Thr Lys Ser Phe Thr Arg Val Val Asp Gly Ala Phe Phe Pro 
305                 310                 315                 320 


Asn Glu Pro Leu Asp Leu Leu Ser Gln Lys Ala Phe Lys Ala Ile Pro 
                325                 330                 335     


Ser Ile Ile Gly Val Asn Asn His Glu Cys Gly Phe Leu Leu Pro Met 
            340                 345                 350         


Lys Glu Ala Pro Glu Ile Leu Ser Gly Ser Asn Lys Ser Leu Ala Leu 
        355                 360                 365             


His Leu Ile Gln Asn Ile Leu His Ile Pro Pro Gln Tyr Leu His Leu 
    370                 375                 380                 


Val Ala Asn Glu Tyr Phe His Asp Lys His Ser Leu Thr Glu Ile Arg 
385                 390                 395                 400 


Asp Ser Leu Leu Asp Leu Leu Gly Asp Val Phe Phe Val Val Pro Ala 
                405                 410                 415     


Leu Ile Thr Ala Arg Tyr His Arg Glu Gly Ala Thr Glu Glu Glu Lys 
            420                 425                 430         


Leu Leu Ser Arg Lys Met Met Lys Tyr Trp Ala Thr Phe Ala Arg Thr 
        435                 440                 445             


Gly Asn Pro Asn Gly Asn Asp Leu Ser Leu Trp Pro Ala Tyr Asn Leu 
    450                 455                 460                 


Thr Glu Gln Tyr Leu Gln Leu Asp Leu Asn Met Ser Leu Gly Gln Arg 
465                 470                 475                 480 


Leu Lys Glu Pro Arg Val Asp Phe Trp Thr Ser Thr Ile Pro Leu Ile 
                485                 490                 495     


Leu Ser Ala Ser Asp Met Leu His Ser Pro Leu Ser Ser Leu Thr Phe 
            500                 505                 510         


Leu Ser Leu Leu Gln Pro Phe Phe Phe Phe Cys Ala Pro 
        515                 520                 525 


<210>  2655
<211>  545
<212>  PRT
<213>  Homo Sapiens

<400>  2655

Met Ser Gly Asn Trp Val His Pro Gly Gln Ile Leu Ile Trp Ala Ile 
1               5                   10                  15      


Trp Val Leu Ala Ala Pro Thr Lys Gly Pro Ser Ala Glu Gly Pro Gln 
            20                  25                  30          


Arg Asn Thr Arg Leu Gly Trp Ile Gln Gly Lys Gln Val Thr Val Leu 
        35                  40                  45              


Gly Ser Pro Val Pro Val Asn Val Phe Leu Gly Val Pro Phe Ala Ala 
    50                  55                  60                  


Pro Pro Leu Gly Ser Leu Arg Phe Thr Asn Pro Gln Pro Ala Ser Pro 
65                  70                  75                  80  


Trp Asp Asn Leu Arg Glu Ala Thr Ser Tyr Pro Asn Leu Cys Leu Gln 
                85                  90                  95      


Asn Ser Glu Trp Leu Leu Leu Asp Gln His Met Leu Lys Val Leu Val 
            100                 105                 110         


Trp Phe Pro Gly Gly Ala Phe Lys Thr Gly Ser Ala Ser Ile Phe Asp 
        115                 120                 125             


Gly Ser Ala Leu Ala Ala Tyr Glu Asp Val Leu Val Val Val Val Gln 
    130                 135                 140                 


Tyr Arg Leu Gly Ile Phe Gly Phe Phe Thr Thr Trp Asp Gln His Ala 
145                 150                 155                 160 


Pro Gly Asn Trp Ala Phe Lys Asp Gln Val Ala Ala Leu Ser Trp Val 
                165                 170                 175     


Gln Lys Asn Ile Glu Phe Phe Gly Gly Asp Pro Ser Ser Val Thr Ile 
            180                 185                 190         


Phe Gly Glu Ser Ala Gly Ala Ile Ser Val Ser Ser Leu Ile Leu Ser 
        195                 200                 205             


Pro Met Ala Lys Gly Leu Phe His Lys Ala Ile Met Glu Ser Gly Val 
    210                 215                 220                 


Ala Ile Ile Pro Tyr Leu Glu Ala His Asp Tyr Glu Lys Ser Glu Asp 
225                 230                 235                 240 


Leu Gln Val Val Ala His Phe Cys Gly Asn Asn Ala Ser Asp Ser Glu 
                245                 250                 255     


Ala Leu Leu Arg Cys Leu Arg Thr Lys Pro Ser Lys Glu Leu Leu Thr 
            260                 265                 270         


Leu Ser Gln Lys Thr Lys Ser Phe Thr Arg Val Val Asp Gly Ala Phe 
        275                 280                 285             


Phe Pro Asn Glu Pro Leu Asp Leu Leu Ser Gln Lys Ala Phe Lys Ala 
    290                 295                 300                 


Ile Pro Ser Ile Ile Gly Val Asn Asn His Glu Cys Gly Phe Leu Leu 
305                 310                 315                 320 


Pro Met Lys Glu Ala Pro Glu Ile Leu Ser Gly Ser Asn Lys Ser Leu 
                325                 330                 335     


Ala Leu His Leu Ile Gln Asn Ile Leu His Ile Pro Pro Gln Tyr Leu 
            340                 345                 350         


His Leu Val Ala Asn Glu Tyr Phe His Asp Lys His Ser Leu Thr Glu 
        355                 360                 365             


Ile Arg Asp Ser Leu Leu Asp Leu Leu Gly Asp Val Phe Phe Val Val 
    370                 375                 380                 


Pro Ala Leu Ile Thr Ala Arg Tyr His Arg Asp Ala Gly Ala Pro Val 
385                 390                 395                 400 


Tyr Phe Tyr Glu Phe Arg His Arg Pro Gln Cys Phe Glu Asp Thr Lys 
                405                 410                 415     


Pro Ala Phe Val Lys Ala Asp His Ala Asp Glu Val Arg Phe Val Phe 
            420                 425                 430         


Gly Gly Ala Phe Leu Lys Gly Asp Ile Val Met Phe Glu Gly Ala Thr 
        435                 440                 445             


Glu Glu Glu Lys Leu Leu Ser Arg Lys Met Met Lys Tyr Trp Ala Thr 
    450                 455                 460                 


Phe Ala Arg Thr Gly Asn Pro Asn Gly Asn Asp Leu Ser Leu Trp Pro 
465                 470                 475                 480 


Ala Tyr Asn Leu Thr Glu Gln Tyr Leu Gln Leu Asp Leu Asn Met Ser 
                485                 490                 495     


Leu Gly Gln Arg Leu Lys Glu Pro Arg Val Asp Phe Trp Thr Ser Thr 
            500                 505                 510         


Ile Pro Leu Ile Leu Ser Ala Ser Asp Met Leu His Ser Pro Leu Ser 
        515                 520                 525             


Ser Leu Thr Phe Leu Ser Leu Leu Gln Pro Phe Phe Phe Phe Cys Ala 
    530                 535                 540                 


Pro 
545 


<210>  2656
<211>  433
<212>  PRT
<213>  Homo Sapiens

<400>  2656

Met Leu Ala Ala Thr Val Leu Thr Leu Ala Leu Leu Gly Asn Ala His 
1               5                   10                  15      


Ala Cys Ser Lys Gly Thr Ser His Glu Ala Gly Ile Val Cys Arg Ile 
            20                  25                  30          


Thr Lys Pro Ala Leu Leu Val Leu Asn His Glu Thr Ala Lys Val Ile 
        35                  40                  45              


Gln Thr Ala Phe Gln Arg Ala Ser Tyr Pro Asp Ile Thr Gly Glu Lys 
    50                  55                  60                  


Ala Met Met Leu Leu Gly Gln Val Lys Tyr Gly Leu His Asn Ile Gln 
65                  70                  75                  80  


Ile Ser His Leu Ser Ile Ala Ser Ser Gln Val Glu Leu Val Glu Ala 
                85                  90                  95      


Lys Ser Ile Asp Val Ser Ile Gln Asn Val Ser Val Val Phe Lys Gly 
            100                 105                 110         


Thr Leu Lys Tyr Gly Tyr Thr Thr Ala Trp Trp Leu Gly Ile Asp Gln 
        115                 120                 125             


Ser Ile Asp Phe Glu Ile Asp Ser Ala Ile Asp Leu Gln Ile Asn Thr 
    130                 135                 140                 


Gln Leu Thr Cys Asp Ser Gly Arg Val Arg Thr Asp Ala Pro Asp Cys 
145                 150                 155                 160 


Tyr Leu Ser Phe His Lys Leu Leu Leu His Leu Gln Gly Glu Arg Glu 
                165                 170                 175     


Pro Gly Trp Ile Lys Gln Leu Phe Thr Asn Phe Ile Ser Phe Thr Leu 
            180                 185                 190         


Lys Leu Val Leu Lys Gly Gln Ile Cys Lys Glu Ile Asn Val Ile Ser 
        195                 200                 205             


Asn Ile Met Ala Asp Phe Val Gln Thr Arg Ala Ala Ser Ile Leu Ser 
    210                 215                 220                 


Asp Gly Asp Ile Gly Val Asp Ile Ser Leu Thr Gly Asp Pro Val Ile 
225                 230                 235                 240 


Thr Ala Ser Tyr Leu Glu Ser His His Lys Ala Val Leu Glu Thr Trp 
                245                 250                 255     


Gly Phe Asn Thr Asn Gln Glu Ile Phe Gln Glu Val Val Gly Gly Phe 
            260                 265                 270         


Pro Ser Gln Ala Gln Val Thr Val His Cys Leu Lys Met Pro Lys Ile 
        275                 280                 285             


Ser Cys Gln Asn Lys Gly Val Val Val Asn Ser Ser Val Met Val Lys 
    290                 295                 300                 


Phe Leu Phe Pro Arg Pro Asp Gln Gln His Ser Val Ala Tyr Thr Phe 
305                 310                 315                 320 


Glu Glu Asp Ile Val Thr Thr Val Gln Ala Ser Tyr Ser Lys Lys Lys 
                325                 330                 335     


Leu Phe Leu Ser Leu Leu Asp Phe Gln Ile Thr Pro Lys Thr Val Ser 
            340                 345                 350         


Asn Leu Thr Glu Ser Ser Ser Glu Ser Val Gln Ser Phe Leu Gln Ser 
        355                 360                 365             


Met Ile Thr Ala Val Gly Ile Pro Glu Val Met Ser Arg Leu Glu Val 
    370                 375                 380                 


Val Phe Thr Ala Leu Met Asn Ser Lys Gly Val Ser Leu Phe Asp Ile 
385                 390                 395                 400 


Ile Asn Pro Glu Ile Ile Thr Arg Asp Gly Phe Leu Leu Leu Gln Met 
                405                 410                 415     


Asp Phe Gly Phe Pro Glu His Leu Leu Val Asp Phe Leu Gln Ser Leu 
            420                 425                 430         


Ser 
    


<210>  2657
<211>  493
<212>  PRT
<213>  Homo Sapiens

<400>  2657

Met Leu Ala Ala Thr Val Leu Thr Leu Ala Leu Leu Gly Asn Ala His 
1               5                   10                  15      


Ala Cys Ser Lys Gly Thr Ser His Glu Ala Gly Ile Val Cys Arg Ile 
            20                  25                  30          


Thr Lys Pro Ala Leu Leu Val Leu Asn His Glu Thr Ala Lys Val Ile 
        35                  40                  45              


Gln Thr Ala Phe Gln Arg Ala Ser Tyr Pro Asp Ile Thr Gly Glu Lys 
    50                  55                  60                  


Ala Met Met Leu Leu Gly Gln Val Lys Tyr Gly Leu His Asn Ile Gln 
65                  70                  75                  80  


Ile Ser His Leu Ser Ile Ala Ser Ser Gln Val Glu Leu Val Glu Ala 
                85                  90                  95      


Lys Ser Ile Asp Val Ser Ile Gln Asn Val Ser Val Val Phe Lys Gly 
            100                 105                 110         


Thr Leu Lys Tyr Gly Tyr Thr Thr Ala Trp Trp Leu Gly Ile Asp Gln 
        115                 120                 125             


Ser Ile Asp Phe Glu Ile Asp Ser Ala Ile Asp Leu Gln Ile Asn Thr 
    130                 135                 140                 


Gln Leu Thr Cys Asp Ser Gly Arg Val Arg Thr Asp Ala Pro Asp Cys 
145                 150                 155                 160 


Tyr Leu Ser Phe His Lys Leu Leu Leu His Leu Gln Gly Glu Arg Glu 
                165                 170                 175     


Pro Gly Trp Ile Lys Gln Leu Phe Thr Asn Phe Ile Ser Phe Thr Leu 
            180                 185                 190         


Lys Leu Val Leu Lys Gly Gln Ile Cys Lys Glu Ile Asn Val Ile Ser 
        195                 200                 205             


Asn Ile Met Ala Asp Phe Val Gln Thr Arg Ala Ala Ser Ile Leu Ser 
    210                 215                 220                 


Asp Gly Asp Ile Gly Val Asp Ile Ser Leu Thr Gly Asp Pro Val Ile 
225                 230                 235                 240 


Thr Ala Ser Tyr Leu Glu Ser His His Lys Gly His Phe Ile Tyr Lys 
                245                 250                 255     


Asn Val Ser Glu Asp Leu Pro Leu Pro Thr Phe Ser Pro Thr Leu Leu 
            260                 265                 270         


Gly Asp Ser Arg Met Leu Tyr Phe Trp Phe Ser Glu Arg Val Phe His 
        275                 280                 285             


Ser Leu Ala Lys Val Ala Phe Gln Asp Gly Arg Leu Met Leu Ser Leu 
    290                 295                 300                 


Met Gly Asp Glu Phe Lys Ala Val Leu Glu Thr Trp Gly Phe Asn Thr 
305                 310                 315                 320 


Asn Gln Glu Ile Phe Gln Glu Val Val Gly Gly Phe Pro Ser Gln Ala 
                325                 330                 335     


Gln Val Thr Val His Cys Leu Lys Met Pro Lys Ile Ser Cys Gln Asn 
            340                 345                 350         


Lys Gly Val Val Val Asn Ser Ser Val Met Val Lys Phe Leu Phe Pro 
        355                 360                 365             


Arg Pro Asp Gln Gln His Ser Val Ala Tyr Thr Phe Glu Glu Asp Ile 
    370                 375                 380                 


Val Thr Thr Val Gln Ala Ser Tyr Ser Lys Lys Lys Leu Phe Leu Ser 
385                 390                 395                 400 


Leu Leu Asp Phe Gln Ile Thr Pro Lys Thr Val Ser Asn Leu Thr Glu 
                405                 410                 415     


Ser Ser Ser Glu Ser Val Gln Ser Phe Leu Gln Ser Met Ile Thr Ala 
            420                 425                 430         


Val Gly Ile Pro Glu Val Met Ser Arg Leu Glu Val Val Phe Thr Ala 
        435                 440                 445             


Leu Met Asn Ser Lys Gly Val Ser Leu Phe Asp Ile Ile Asn Pro Glu 
    450                 455                 460                 


Ile Ile Thr Arg Asp Gly Phe Leu Leu Leu Gln Met Asp Phe Gly Phe 
465                 470                 475                 480 


Pro Glu His Leu Leu Val Asp Phe Leu Gln Ser Leu Ser 
                485                 490             


<210>  2658
<211>  428
<212>  PRT
<213>  Homo Sapiens

<400>  2658

Met Met Leu Leu Gly Gln Val Lys Tyr Gly Leu His Asn Ile Gln Ile 
1               5                   10                  15      


Ser His Leu Ser Ile Ala Ser Ser Gln Val Glu Leu Val Glu Ala Lys 
            20                  25                  30          


Ser Ile Asp Val Ser Ile Gln Asn Val Ser Val Val Phe Lys Gly Thr 
        35                  40                  45              


Leu Lys Tyr Gly Tyr Thr Thr Ala Trp Trp Leu Gly Ile Asp Gln Ser 
    50                  55                  60                  


Ile Asp Phe Glu Ile Asp Ser Ala Ile Asp Leu Gln Ile Asn Thr Gln 
65                  70                  75                  80  


Leu Thr Cys Asp Ser Gly Arg Val Arg Thr Asp Ala Pro Asp Cys Tyr 
                85                  90                  95      


Leu Ser Phe His Lys Leu Leu Leu His Leu Gln Gly Glu Arg Glu Pro 
            100                 105                 110         


Gly Trp Ile Lys Gln Leu Phe Thr Asn Phe Ile Ser Phe Thr Leu Lys 
        115                 120                 125             


Leu Val Leu Lys Gly Gln Ile Cys Lys Glu Ile Asn Val Ile Ser Asn 
    130                 135                 140                 


Ile Met Ala Asp Phe Val Gln Thr Arg Ala Ala Ser Ile Leu Ser Asp 
145                 150                 155                 160 


Gly Asp Ile Gly Val Asp Ile Ser Leu Thr Gly Asp Pro Val Ile Thr 
                165                 170                 175     


Ala Ser Tyr Leu Glu Ser His His Lys Gly His Phe Ile Tyr Lys Asn 
            180                 185                 190         


Val Ser Glu Asp Leu Pro Leu Pro Thr Phe Ser Pro Thr Leu Leu Gly 
        195                 200                 205             


Asp Ser Arg Met Leu Tyr Phe Trp Phe Ser Glu Arg Val Phe His Ser 
    210                 215                 220                 


Leu Ala Lys Val Ala Phe Gln Asp Gly Arg Leu Met Leu Ser Leu Met 
225                 230                 235                 240 


Gly Asp Glu Phe Lys Ala Val Leu Glu Thr Trp Gly Phe Asn Thr Asn 
                245                 250                 255     


Gln Glu Ile Phe Gln Glu Val Val Gly Gly Phe Pro Ser Gln Ala Gln 
            260                 265                 270         


Val Thr Val His Cys Leu Lys Met Pro Lys Ile Ser Cys Gln Asn Lys 
        275                 280                 285             


Gly Val Val Val Asn Ser Ser Val Met Val Lys Phe Leu Phe Pro Arg 
    290                 295                 300                 


Pro Asp Gln Gln His Ser Val Ala Tyr Thr Phe Glu Glu Asp Ile Val 
305                 310                 315                 320 


Thr Thr Val Gln Ala Ser Tyr Ser Lys Lys Lys Leu Phe Leu Ser Leu 
                325                 330                 335     


Leu Asp Phe Gln Ile Thr Pro Lys Thr Val Ser Asn Leu Thr Glu Ser 
            340                 345                 350         


Ser Ser Glu Ser Val Gln Ser Phe Leu Gln Ser Met Ile Thr Ala Val 
        355                 360                 365             


Gly Ile Pro Glu Val Met Ser Arg Leu Glu Val Val Phe Thr Ala Leu 
    370                 375                 380                 


Met Asn Ser Lys Gly Val Ser Leu Phe Asp Ile Ile Asn Pro Glu Ile 
385                 390                 395                 400 


Ile Thr Arg Asp Gly Phe Leu Leu Leu Gln Met Asp Phe Gly Phe Pro 
                405                 410                 415     


Glu His Leu Leu Val Asp Phe Leu Gln Ser Leu Ser 
            420                 425             


<210>  2659
<211>  784
<212>  PRT
<213>  Homo Sapiens

<400>  2659

Met Glu Thr Ala Ile Trp Arg Arg Ser Tyr Ile Ser Leu Ile Ser Ser 
1               5                   10                  15      


Glu Arg Pro Val His Asn Trp Arg Gly Lys Ser Val Gln Lys Lys Gln 
            20                  25                  30          


Ala Glu Ser Lys Ser Gln Ile Lys Leu His Thr Gln Ser Ala Pro Phe 
        35                  40                  45              


Gly Leu Cys Pro Lys Asp Met Met Leu Thr Gln Ala Pro Ser Ser Val 
    50                  55                  60                  


Val Arg Ser Arg Asn Ser Arg Asn His Thr Val Asn Ser Gly Gly Ser 
65                  70                  75                  80  


Cys Leu Ser Ala Ser Thr Val Ala Ile Pro Ala Ile Asn Asp Ser Ser 
                85                  90                  95      


Ala Ala Met Ser Ala Cys Ser Thr Ile Ser Ala Gln Pro Ala Ser Ser 
            100                 105                 110         


Met Asp Thr Gln Met His Ser Pro Lys Lys Gln Glu Arg Val Asn Lys 
        115                 120                 125             


Arg Val Ile Trp Gly Ile Glu Val Ala Glu Glu Leu His Trp Lys Gly 
    130                 135                 140                 


Trp Glu Leu Gly Lys Glu Thr Thr Arg Asn Leu Val Leu Lys Asn Arg 
145                 150                 155                 160 


Ser Leu Lys Leu Gln Lys Met Lys Tyr Arg Pro Pro Lys Thr Lys Phe 
                165                 170                 175     


Phe Phe Thr Val Ile Pro Gln Pro Ile Phe Leu Ser Pro Gly Ile Thr 
            180                 185                 190         


Leu Thr Leu Pro Ile Val Phe Arg Pro Leu Glu Ala Lys Glu Tyr Met 
        195                 200                 205             


Asp Gln Leu Trp Phe Glu Lys Ala Glu Gly Met Phe Cys Val Gly Leu 
    210                 215                 220                 


Arg Ala Thr Leu Pro Cys His Arg Leu Ile Cys Arg Pro Pro Ser Leu 
225                 230                 235                 240 


Gln Leu Pro Met Cys Ala Val Gly Asp Thr Thr Glu Ala Phe Phe Cys 
                245                 250                 255     


Leu Asp Asn Val Gly Asp Leu Pro Thr Phe Phe Thr Trp Glu Phe Ser 
            260                 265                 270         


Ser Pro Phe Gln Met Leu Pro Ala Thr Gly Leu Leu Glu Pro Gly Gln 
        275                 280                 285             


Ala Ser Gln Ile Lys Val Thr Phe Gln Pro Leu Thr Ala Val Ile Tyr 
    290                 295                 300                 


Glu Val Gln Ala Thr Cys Trp Tyr Gly Ala Gly Ser Arg Gln Arg Ser 
305                 310                 315                 320 


Ser Ile Gln Leu Gln Ala Val Ala Lys Cys Ala Gln Leu Leu Val Ser 
                325                 330                 335     


Ile Lys His Lys Cys Pro Glu Asp Gln Asp Ala Glu Gly Phe Gln Lys 
            340                 345                 350         


Leu Leu Tyr Phe Gly Ser Val Ala Val Gly Cys Thr Ser Glu Arg Gln 
        355                 360                 365             


Ile Arg Leu His Asn Pro Ser Ala Val Asn Ala Pro Phe Arg Ile Glu 
    370                 375                 380                 


Ile Ser Pro Asp Glu Leu Ala Glu Asp Gln Ala Phe Ser Cys Pro Thr 
385                 390                 395                 400 


Ala His Gly Ile Val Leu Pro Gly Glu Lys Lys Cys Val Ser Val Phe 
                405                 410                 415     


Phe His Pro Lys Thr Leu Asp Thr Arg Thr Val Asp Tyr Cys Ser Ile 
            420                 425                 430         


Met Pro Ser Gly Cys Ala Ser Lys Thr Leu Leu Lys Val Val Gly Phe 
        435                 440                 445             


Cys Arg Gly Pro Ala Val Ser Leu Gln His Tyr Cys Val Asn Phe Ser 
    450                 455                 460                 


Trp Val Asn Leu Gly Glu Arg Ser Glu Gln Pro Leu Trp Ile Glu Asn 
465                 470                 475                 480 


Gln Ser Asp Cys Thr Ala His Phe Gln Phe Ala Ile Asp Cys Leu Glu 
                485                 490                 495     


Ser Val Phe Thr Ile Arg Pro Ala Phe Gly Thr Leu Val Gly Lys Ala 
            500                 505                 510         


Arg Met Thr Leu His Cys Ala Phe Gln Pro Thr His Pro Ile Ile Cys 
        515                 520                 525             


Phe Arg Arg Val Ala Cys Leu Ile His His Gln Asp Pro Leu Phe Leu 
    530                 535                 540                 


Asp Leu Met Gly Thr Cys His Ser Asp Ser Thr Lys Pro Ala Ile Leu 
545                 550                 555                 560 


Lys Pro Gln His Leu Thr Trp Tyr Arg Thr His Leu Ala Arg Gly Leu 
                565                 570                 575     


Thr Leu Tyr Pro Pro Asp Ile Leu Asp Ala Met Leu Lys Glu Lys Lys 
            580                 585                 590         


Leu Ala Gln Asp Gln Asn Gly Ala Leu Met Ile Pro Ile Gln Asp Leu 
        595                 600                 605             


Glu Asp Met Pro Ala Pro Gln Tyr Pro Tyr Ile Pro Pro Met Thr Glu 
    610                 615                 620                 


Phe Phe Phe Asp Gly Thr Ser Asp Ile Thr Ile Phe Pro Pro Pro Ile 
625                 630                 635                 640 


Ser Val Glu Pro Val Glu Val Asp Phe Gly Ala Cys Pro Gly Pro Glu 
                645                 650                 655     


Ala Pro Asn Pro Val Pro Leu Cys Leu Met Asn His Thr Lys Gly Lys 
            660                 665                 670         


Ile Met Val Val Trp Thr Arg Arg Ser Asp Cys Pro Phe Trp Val Thr 
        675                 680                 685             


Pro Glu Ser Cys Asp Val Pro Pro Leu Lys Ser Met Ala Met Arg Leu 
    690                 695                 700                 


His Phe Gln Pro Pro His Pro Asn Cys Leu Tyr Thr Val Glu Leu Glu 
705                 710                 715                 720 


Ala Phe Ala Ile Tyr Lys Val Cys Ala Arg Asn Glu Arg Glu Glu Cys 
                725                 730                 735     


Gly Val Ser Ala Arg Ser Leu Ser Gly Leu Val Gly Trp Gln Glu Val 
            740                 745                 750         


Thr Glu Gly Ser Phe Arg Leu His Pro Leu Arg Ala Arg Leu Ser Leu 
        755                 760                 765             


Gly Trp Thr Val Thr Pro Met Ser Leu Ser Pro Pro Lys Leu Leu Ala 
    770                 775                 780                 


<210>  2660
<211>  234
<212>  PRT
<213>  Homo Sapiens

<400>  2660

Met Glu Thr Ala Ile Trp Arg Arg Ser Tyr Ile Ser Leu Ile Ser Ser 
1               5                   10                  15      


Glu Arg Pro Val His Asn Trp Arg Gly Lys Ser Val Gln Lys Lys Gln 
            20                  25                  30          


Ala Glu Ser Lys Ser Gln Ile Lys Leu His Thr Gln Ser Ala Pro Phe 
        35                  40                  45              


Gly Leu Cys Pro Lys Asp Met Met Leu Thr Gln Ala Pro Ser Ser Val 
    50                  55                  60                  


Val Arg Ser Arg Asn Ser Arg Asn His Thr Val Asn Ser Gly Gly Ser 
65                  70                  75                  80  


Cys Leu Ser Ala Ser Thr Val Ala Ile Pro Ala Ile Asn Asp Ser Ser 
                85                  90                  95      


Ala Ala Met Ser Ala Cys Ser Thr Ile Ser Ala Gln Pro Ala Ser Ser 
            100                 105                 110         


Met Asp Thr Gln Met His Ser Pro Lys Lys Gln Glu Arg Val Asn Lys 
        115                 120                 125             


Arg Val Ile Trp Gly Ile Glu Val Ala Glu Glu Leu His Trp Lys Gly 
    130                 135                 140                 


Trp Glu Leu Gly Lys Glu Thr Thr Arg Asn Leu Val Leu Lys Asn Arg 
145                 150                 155                 160 


Ser Leu Lys Leu Gln Lys Met Lys Tyr Arg Pro Pro Lys Thr Lys Phe 
                165                 170                 175     


Phe Phe Thr Val Ile Pro Gln Pro Ile Phe Leu Ser Pro Gly Ile Thr 
            180                 185                 190         


Leu Thr Leu Pro Ile Val Phe Arg Pro Leu Glu Ala Pro Leu Thr Ala 
        195                 200                 205             


Val Ile Tyr Glu Val Gln Ala Thr Cys Trp Tyr Gly Ala Gly Ser Arg 
    210                 215                 220                 


Gln Arg Ser Ser Ile Gln Leu Gln Ala Val 
225                 230                 


<210>  2661
<211>  1925
<212>  PRT
<213>  Homo Sapiens

<400>  2661

Met Phe Thr Leu Thr Gly Cys Arg Leu Val Glu Lys Thr Gln Lys Val 
1               5                   10                  15      


Glu Asn Pro Ser Val Ser Phe Ala Ser Ser Phe Pro Leu Ile Pro Leu 
            20                  25                  30          


Leu Leu Arg Gly Lys Ser Val Gln Lys Lys Gln Ala Glu Ser Lys Ser 
        35                  40                  45              


Gln Ile Lys Leu His Thr Gln Ser Ala Pro Phe Gly Leu Cys Pro Lys 
    50                  55                  60                  


Asp Met Met Leu Thr Gln Ala Pro Ser Ser Val Val Arg Ser Arg Asn 
65                  70                  75                  80  


Ser Arg Asn His Thr Val Asn Ser Gly Gly Ser Cys Leu Ser Ala Ser 
                85                  90                  95      


Thr Val Ala Ile Pro Ala Ile Asn Asp Ser Ser Ala Ala Met Ser Ala 
            100                 105                 110         


Cys Ser Thr Ile Ser Ala Gln Pro Ala Ser Ser Met Asp Thr Gln Met 
        115                 120                 125             


His Ser Pro Lys Lys Gln Glu Arg Val Asn Lys Arg Val Ile Trp Gly 
    130                 135                 140                 


Ile Glu Val Ala Glu Glu Leu His Trp Lys Gly Trp Glu Leu Gly Lys 
145                 150                 155                 160 


Glu Thr Thr Arg Asn Leu Val Leu Lys Asn Arg Ser Leu Lys Leu Gln 
                165                 170                 175     


Lys Met Lys Tyr Arg Pro Pro Lys Thr Lys Phe Phe Phe Thr Val Ile 
            180                 185                 190         


Pro Gln Pro Ile Phe Leu Ser Pro Gly Ile Thr Leu Thr Leu Pro Ile 
        195                 200                 205             


Val Phe Arg Pro Leu Glu Ala Lys Glu Tyr Met Asp Gln Leu Trp Phe 
    210                 215                 220                 


Glu Lys Ala Glu Gly Met Phe Cys Val Gly Leu Arg Ala Thr Leu Pro 
225                 230                 235                 240 


Cys His Arg Leu Ile Cys Arg Pro Pro Ser Leu Gln Leu Pro Met Cys 
                245                 250                 255     


Ala Val Gly Asp Thr Thr Glu Ala Phe Phe Cys Leu Asp Asn Val Gly 
            260                 265                 270         


Asp Leu Pro Thr Phe Phe Thr Trp Glu Phe Ser Ser Pro Phe Gln Met 
        275                 280                 285             


Leu Pro Ala Thr Gly Leu Leu Glu Pro Gly Gln Ala Ser Gln Ile Lys 
    290                 295                 300                 


Val Thr Phe Gln Pro Leu Thr Ala Val Ile Tyr Glu Val Gln Ala Thr 
305                 310                 315                 320 


Cys Trp Tyr Gly Ala Gly Ser Arg Gln Arg Ser Ser Ile Gln Leu Gln 
                325                 330                 335     


Ala Val Ala Lys Cys Ala Gln Leu Leu Val Ser Ile Lys His Lys Cys 
            340                 345                 350         


Pro Glu Asp Gln Asp Ala Glu Gly Phe Gln Lys Leu Leu Tyr Phe Gly 
        355                 360                 365             


Ser Val Ala Val Gly Cys Thr Ser Glu Arg Gln Ile Arg Leu His Asn 
    370                 375                 380                 


Pro Ser Ala Val Asn Ala Pro Phe Arg Ile Glu Ile Ser Pro Asp Glu 
385                 390                 395                 400 


Leu Ala Glu Asp Gln Ala Phe Ser Cys Pro Thr Ala His Gly Ile Val 
                405                 410                 415     


Leu Pro Gly Glu Lys Lys Cys Val Ser Val Phe Phe His Pro Lys Thr 
            420                 425                 430         


Leu Asp Thr Arg Thr Val Asp Tyr Cys Ser Ile Met Pro Ser Gly Cys 
        435                 440                 445             


Ala Ser Lys Thr Leu Leu Lys Val Val Gly Phe Cys Arg Gly Pro Ala 
    450                 455                 460                 


Val Ser Leu Gln His Tyr Cys Val Asn Phe Ser Trp Val Asn Leu Gly 
465                 470                 475                 480 


Glu Arg Ser Glu Gln Pro Leu Trp Ile Glu Asn Gln Ser Asp Cys Thr 
                485                 490                 495     


Ala His Phe Gln Phe Ala Ile Asp Cys Leu Glu Ser Val Phe Thr Ile 
            500                 505                 510         


Arg Pro Ala Phe Gly Thr Leu Val Gly Lys Ala Arg Met Thr Leu His 
        515                 520                 525             


Cys Ala Phe Gln Pro Thr His Pro Ile Ile Cys Phe Arg Arg Val Ala 
    530                 535                 540                 


Cys Leu Ile His His Gln Asp Pro Leu Phe Leu Asp Leu Met Gly Thr 
545                 550                 555                 560 


Cys His Ser Asp Ser Thr Lys Pro Ala Ile Leu Lys Pro Gln His Leu 
                565                 570                 575     


Thr Trp Tyr Arg Thr His Leu Ala Arg Gly Leu Thr Leu Tyr Pro Pro 
            580                 585                 590         


Asp Ile Leu Asp Ala Met Leu Lys Glu Lys Lys Leu Ala Gln Asp Gln 
        595                 600                 605             


Asn Gly Ala Leu Met Ile Pro Ile Gln Asp Leu Glu Asp Met Pro Ala 
    610                 615                 620                 


Pro Gln Tyr Pro Tyr Ile Pro Pro Met Thr Glu Phe Phe Phe Asp Gly 
625                 630                 635                 640 


Thr Ser Asp Ile Thr Ile Phe Pro Pro Pro Ile Ser Val Glu Pro Val 
                645                 650                 655     


Glu Val Asp Phe Gly Ala Cys Pro Gly Pro Glu Ala Pro Asn Pro Val 
            660                 665                 670         


Pro Leu Cys Leu Met Asn His Thr Lys Gly Lys Ile Met Val Val Trp 
        675                 680                 685             


Thr Arg Arg Ser Asp Cys Pro Phe Trp Val Thr Pro Glu Ser Cys Asp 
    690                 695                 700                 


Val Pro Pro Leu Lys Ser Met Ala Met Arg Leu His Phe Gln Pro Pro 
705                 710                 715                 720 


His Pro Asn Cys Leu Tyr Thr Val Glu Leu Glu Ala Phe Ala Ile Tyr 
                725                 730                 735     


Lys Val Leu Gln Ser Tyr Ser Asn Ile Glu Glu Asp Cys Thr Met Cys 
            740                 745                 750         


Pro Ser Trp Cys Leu Thr Val Arg Ala Arg Gly His Ser Tyr Phe Ala 
        755                 760                 765             


Gly Phe Glu His His Ile Pro Gln Tyr Ser Leu Asp Val Pro Lys Leu 
    770                 775                 780                 


Phe Pro Ala Val Ser Ser Gly Glu Pro Thr Tyr Arg Ser Leu Leu Leu 
785                 790                 795                 800 


Val Asn Lys Asp Cys Lys Leu Leu Thr Phe Ser Leu Ala Pro Gln Arg 
                805                 810                 815     


Gly Ser Asp Val Ile Leu Arg Pro Thr Ser Gly Leu Val Ala Pro Gly 
            820                 825                 830         


Ala His Gln Ile Ile Leu Ile Cys Thr Tyr Pro Glu Gly Ser Ser Trp 
        835                 840                 845             


Lys Gln His Thr Phe Tyr Leu Gln Cys Asn Ala Ser Pro Gln Tyr Leu 
    850                 855                 860                 


Lys Glu Val Ser Met Tyr Ser Arg Glu Glu Pro Leu Gln Leu Lys Leu 
865                 870                 875                 880 


Asp Thr His Lys Ser Leu Tyr Phe Lys Pro Thr Trp Val Gly Cys Ser 
                885                 890                 895     


Ser Thr Ser Pro Phe Thr Phe Arg Asn Pro Ser Arg Leu Pro Leu Gln 
            900                 905                 910         


Phe Glu Trp Arg Val Ser Glu Gln His Arg Lys Leu Leu Ala Val Gln 
        915                 920                 925             


Pro Ser Arg Gly Leu Ile Gln Pro Asn Glu Arg Leu Thr Leu Thr Trp 
    930                 935                 940                 


Thr Phe Ser Pro Leu Glu Glu Thr Lys Tyr Leu Phe Gln Val Gly Met 
945                 950                 955                 960 


Trp Val Trp Glu Ala Gly Leu Ser Pro Asn Ala Asn Pro Ala Ala Thr 
                965                 970                 975     


Thr His Tyr Met Leu Arg Leu Val Gly Val Gly Leu Thr Ser Ser Leu 
            980                 985                 990         


Ser Ala Lys Glu Lys Glu Leu Ala  Phe Gly Asn Val Leu  Val Asn Ser 
        995                 1000                 1005             


Lys Gln  Ser Arg Phe Leu Val  Leu Leu Asn Asp Gly  Asn Cys Thr 
    1010                 1015                 1020             


Leu Tyr  Tyr Arg Leu Tyr Leu  Glu Gln Gly Ser Pro  Glu Ala Val 
    1025                 1030                 1035             


Asp Asn  His Pro Leu Ala Leu  Gln Leu Asp Arg Thr  Glu Gly Ser 
    1040                 1045                 1050             


Met Pro  Pro Arg Ser Gln Asp  Thr Ile Cys Leu Thr  Ala Cys Pro 
    1055                 1060                 1065             


Lys Gln  Arg Ser Gln Tyr Ser  Trp Thr Ile Thr Tyr  Ser Leu Leu 
    1070                 1075                 1080             


Ser His  Arg Asp Asn Lys Ala  Gly Glu Lys Gln Glu  Leu Cys Cys 
    1085                 1090                 1095             


Val Ser  Leu Val Ala Val Tyr  Pro Leu Leu Ser Ile  Leu Asp Val 
    1100                 1105                 1110             


Ser Ser  Met Gly Ser Ala Glu  Gly Ile Thr Arg Lys  His Leu Trp 
    1115                 1120                 1125             


Arg Leu  Phe Ser Leu Asp Leu  Leu Asn Ser Tyr Leu  Glu Arg Asp 
    1130                 1135                 1140             


Pro Thr  Pro Cys Glu Leu Thr  Tyr Lys Val Pro Thr  Arg His Ser 
    1145                 1150                 1155             


Met Ser  Gln Ile Pro Pro Val  Leu Thr Pro Leu Arg  Leu Asp Phe 
    1160                 1165                 1170             


Asn Phe  Gly Ala Ala Pro Phe  Lys Ala Pro Pro Ser  Val Val Phe 
    1175                 1180                 1185             


Leu Ala  Leu Lys Asn Ser Gly  Val Val Ser Leu Asp  Trp Ala Phe 
    1190                 1195                 1200             


Leu Leu  Pro Ser Asp Gln Arg  Ile Asp Val Glu Leu  Trp Ala Glu 
    1205                 1210                 1215             


Gln Ala  Glu Leu Asn Ser Thr  Glu Leu His Gln Met  Arg Val Gln 
    1220                 1225                 1230             


Asp Asn  Cys Leu Phe Ser Ile  Ser Pro Lys Ala Gly  Ser Leu Ser 
    1235                 1240                 1245             


Pro Gly  Gln Glu Gln Met Val  Glu Leu Lys Tyr Ser  His Leu Phe 
    1250                 1255                 1260             


Ile Gly  Thr Asp His Leu Pro  Val Leu Phe Lys Val  Ser His Gly 
    1265                 1270                 1275             


Arg Glu  Ile Leu Leu Asn Phe  Ile Gly Val Thr Val  Lys Pro Glu 
    1280                 1285                 1290             


Gln Lys  Tyr Val His Phe Thr  Ser Thr Thr His Gln  Phe Ile Pro 
    1295                 1300                 1305             


Ile Pro  Ile Gly Asp Thr Leu  Pro Pro Arg Gln Ile  Tyr Glu Leu 
    1310                 1315                 1320             


Tyr Asn  Gly Gly Ser Val Pro  Val Thr Tyr Glu Val  Gln Thr Asp 
    1325                 1330                 1335             


Val Leu  Ser Gln Val Gln Glu  Lys Asn Phe Asp His  Pro Ile Phe 
    1340                 1345                 1350             


Cys Cys  Leu Asn Pro Lys Gly  Glu Ile Gln Pro Gly  Ser Thr Ala 
    1355                 1360                 1365             


Arg Val  Leu Trp Ile Phe Ser  Pro Ile Glu Ala Lys  Thr Tyr Thr 
    1370                 1375                 1380             


Val Asp  Val Pro Ile His Ile  Leu Gly Trp Asn Ser  Ala Leu Ile 
    1385                 1390                 1395             


His Phe  Gln Gly Val Gly Tyr  Asn Pro His Met Met  Gly Asp Thr 
    1400                 1405                 1410             


Ala Pro  Phe His Asn Ile Ser  Ser Trp Asp Asn Ser  Ser Ile His 
    1415                 1420                 1425             


Ser Arg  Leu Val Val Pro Gly  Gln Asn Val Phe Leu  Ser Gln Ser 
    1430                 1435                 1440             


His Ile  Ser Leu Gly Asn Ile  Pro Val Gln Ser Lys  Cys Ser Arg 
    1445                 1450                 1455             


Leu Leu  Phe Leu Asn Asn Ile  Ser Lys Asn Glu Glu  Ile Ala Phe 
    1460                 1465                 1470             


Ser Trp  Gln Pro Ser Pro Leu  Asp Phe Gly Glu Val  Ser Val Ser 
    1475                 1480                 1485             


Pro Met  Ile Gly Val Val Ala  Pro Glu Glu Thr Val  Pro Phe Val 
    1490                 1495                 1500             


Val Thr  Leu Arg Ala Ser Val  His Ala Ser Phe Tyr  Ser Ala Asp 
    1505                 1510                 1515             


Leu Val  Cys Lys Leu Tyr Ser  Gln Gln Leu Met Arg  Gln Tyr His 
    1520                 1525                 1530             


Lys Glu  Leu Gln Glu Trp Lys  Asp Glu Lys Val Arg  Gln Glu Val 
    1535                 1540                 1545             


Glu Phe  Thr Ile Thr Asp Met  Lys Val Lys Lys Arg  Thr Cys Cys 
    1550                 1555                 1560             


Thr Ala  Cys Glu Pro Ala Arg  Lys Tyr Lys Thr Leu  Pro Pro Ile 
    1565                 1570                 1575             


Lys Asn  Gln Gln Ser Val Ser  Arg Pro Ala Ser Trp  Lys Leu Gln 
    1580                 1585                 1590             


Thr Pro  Lys Glu Glu Val Ser  Trp Pro Cys Pro Gln  Pro Pro Ser 
    1595                 1600                 1605             


Pro Gly  Met Leu Cys Leu Gly  Leu Thr Ala Arg Ala  His Ala Thr 
    1610                 1615                 1620             


Asp Tyr  Phe Leu Ala Asn Phe  Phe Ser Glu Phe Pro  Cys His Phe 
    1625                 1630                 1635             


Leu His  Arg Glu Leu Pro Lys  Arg Lys Ala Pro Arg  Glu Glu Ser 
    1640                 1645                 1650             


Glu Thr  Ser Glu Glu Lys Ser  Pro Asn Lys Trp Gly  Pro Val Ser 
    1655                 1660                 1665             


Lys Gln  Lys Lys Gln Leu Leu  Val Asp Ile Leu Thr  Thr Ile Ile 
    1670                 1675                 1680             


Arg Gly  Leu Leu Glu Asp Lys  Asn Phe His Glu Ala  Val Asp Gln 
    1685                 1690                 1695             


Ser Leu  Val Glu Gln Val Pro  Tyr Phe Arg Gln Phe  Trp Asn Glu 
    1700                 1705                 1710             


Gln Ser  Thr Lys Phe Met Asp  Gln Lys Asn Ser Leu  Tyr Leu Met 
    1715                 1720                 1725             


Pro Ile  Leu Pro Val Pro Ser  Ser Ser Trp Glu Asp  Gly Lys Gly 
    1730                 1735                 1740             


Lys Gln  Pro Lys Glu Asp Arg  Pro Glu His Tyr Pro  Gly Leu Gly 
    1745                 1750                 1755             


Lys Lys  Glu Glu Gly Glu Glu  Glu Lys Gly Glu Glu  Glu Glu Glu 
    1760                 1765                 1770             


Glu Leu  Glu Glu Glu Glu Glu  Glu Glu Glu Glu Thr  Glu Glu Glu 
    1775                 1780                 1785             


Glu Leu  Gly Lys Glu Glu Ile  Glu Glu Lys Glu Glu  Glu Arg Asp 
    1790                 1795                 1800             


Glu Lys  Glu Glu Lys Val Ser  Trp Ala Gly Ile Gly  Pro Thr Pro 
    1805                 1810                 1815             


Gln Pro  Glu Ser Gln Glu Ser  Met Gln Trp Gln Trp  Gln Gln Gln 
    1820                 1825                 1830             


Leu Asn  Val Met Val Lys Glu  Glu Gln Glu Gln Asp  Glu Lys Glu 
    1835                 1840                 1845             


Ala Ile  Arg Arg Leu Pro Ala  Phe Ala Asn Leu Gln  Glu Ala Leu 
    1850                 1855                 1860             


Leu Glu  Asn Met Ile Gln Asn  Ile Leu Val Glu Ala  Ser Arg Gly 
    1865                 1870                 1875             


Glu Val  Val Leu Thr Ser Arg  Pro Arg Val Ile Ala  Leu Pro Pro 
    1880                 1885                 1890             


Phe Cys  Val Pro Arg Ser Leu  Thr Pro Asp Thr Leu  Leu Pro Thr 
    1895                 1900                 1905             


Gln Gln  Ala Glu Val Leu His  Pro Val Val Pro Leu  Pro Thr Asp 
    1910                 1915                 1920             


Leu Pro  
    1925 


<210>  2662
<211>  1925
<212>  PRT
<213>  Homo Sapiens

<400>  2662

Met Phe Thr Leu Thr Gly Cys Arg Leu Val Glu Lys Thr Gln Lys Val 
1               5                   10                  15      


Glu Asn Pro Ser Val Ser Phe Ala Ser Ser Phe Pro Leu Ile Pro Leu 
            20                  25                  30          


Leu Leu Arg Gly Lys Ser Val Gln Lys Lys Gln Ala Glu Ser Lys Ser 
        35                  40                  45              


Gln Ile Lys Leu His Thr Gln Ser Ala Pro Phe Gly Leu Cys Pro Lys 
    50                  55                  60                  


Asp Met Met Leu Thr Gln Ala Pro Ser Ser Val Val Arg Ser Arg Asn 
65                  70                  75                  80  


Ser Arg Asn His Thr Val Asn Ser Gly Gly Ser Cys Leu Ser Ala Ser 
                85                  90                  95      


Thr Val Ala Ile Pro Ala Ile Asn Asp Ser Ser Ala Ala Met Ser Ala 
            100                 105                 110         


Cys Ser Thr Ile Ser Ala Gln Pro Ala Ser Ser Met Asp Thr Gln Met 
        115                 120                 125             


His Ser Pro Lys Lys Gln Glu Arg Val Asn Lys Arg Val Ile Trp Gly 
    130                 135                 140                 


Ile Glu Val Ala Glu Glu Leu His Trp Lys Gly Trp Glu Leu Gly Lys 
145                 150                 155                 160 


Glu Thr Thr Arg Asn Leu Val Leu Lys Asn Arg Ser Leu Lys Leu Gln 
                165                 170                 175     


Lys Met Lys Tyr Arg Pro Pro Lys Thr Lys Phe Phe Phe Thr Val Ile 
            180                 185                 190         


Pro Gln Pro Ile Phe Leu Ser Pro Gly Ile Thr Leu Thr Leu Pro Ile 
        195                 200                 205             


Val Phe Arg Pro Leu Glu Ala Lys Glu Tyr Met Asp Gln Leu Trp Phe 
    210                 215                 220                 


Glu Lys Ala Glu Gly Met Phe Cys Val Gly Leu Arg Ala Thr Leu Pro 
225                 230                 235                 240 


Cys His Arg Leu Ile Cys Arg Pro Pro Ser Leu Gln Leu Pro Met Cys 
                245                 250                 255     


Ala Val Gly Asp Thr Thr Glu Ala Phe Phe Cys Leu Asp Asn Val Gly 
            260                 265                 270         


Asp Leu Pro Thr Phe Phe Thr Trp Glu Phe Ser Ser Pro Phe Gln Met 
        275                 280                 285             


Leu Pro Ala Thr Gly Leu Leu Glu Pro Gly Gln Ala Ser Gln Ile Lys 
    290                 295                 300                 


Val Thr Phe Gln Pro Leu Thr Ala Val Ile Tyr Glu Val Gln Ala Thr 
305                 310                 315                 320 


Cys Trp Tyr Gly Ala Gly Ser Arg Gln Arg Ser Ser Ile Gln Leu Gln 
                325                 330                 335     


Ala Val Ala Lys Cys Ala Gln Leu Leu Val Ser Ile Lys His Lys Cys 
            340                 345                 350         


Pro Glu Asp Gln Asp Ala Glu Gly Phe Gln Lys Leu Leu Tyr Phe Gly 
        355                 360                 365             


Ser Val Ala Val Gly Cys Thr Ser Glu Arg Gln Ile Arg Leu His Asn 
    370                 375                 380                 


Pro Ser Ala Val Asn Ala Pro Phe Arg Ile Glu Ile Ser Pro Asp Glu 
385                 390                 395                 400 


Leu Ala Glu Asp Gln Ala Phe Ser Cys Pro Thr Ala His Gly Ile Val 
                405                 410                 415     


Leu Pro Gly Glu Lys Lys Cys Val Ser Val Phe Phe His Pro Lys Thr 
            420                 425                 430         


Leu Asp Thr Arg Thr Val Asp Tyr Cys Ser Ile Met Pro Ser Gly Cys 
        435                 440                 445             


Ala Ser Lys Thr Leu Leu Lys Val Val Gly Phe Cys Arg Gly Pro Ala 
    450                 455                 460                 


Val Ser Leu Gln His Tyr Cys Val Asn Phe Ser Trp Val Asn Leu Gly 
465                 470                 475                 480 


Glu Arg Ser Glu Gln Pro Leu Trp Ile Glu Asn Gln Ser Asp Cys Thr 
                485                 490                 495     


Ala His Phe Gln Phe Ala Ile Asp Cys Leu Glu Ser Val Phe Thr Ile 
            500                 505                 510         


Arg Pro Ala Phe Gly Thr Leu Val Gly Lys Ala Arg Met Thr Leu His 
        515                 520                 525             


Cys Ala Phe Gln Pro Thr His Pro Ile Ile Cys Phe Arg Arg Val Ala 
    530                 535                 540                 


Cys Leu Ile His His Gln Asp Pro Leu Phe Leu Asp Leu Met Gly Thr 
545                 550                 555                 560 


Cys His Ser Asp Ser Thr Lys Pro Ala Ile Leu Lys Pro Gln His Leu 
                565                 570                 575     


Thr Trp Tyr Arg Thr His Leu Ala Arg Gly Leu Thr Leu Tyr Pro Pro 
            580                 585                 590         


Asp Ile Leu Asp Ala Met Leu Lys Glu Lys Lys Leu Ala Gln Asp Gln 
        595                 600                 605             


Asn Gly Ala Leu Met Ile Pro Ile Gln Asp Leu Glu Asp Met Pro Ala 
    610                 615                 620                 


Pro Gln Tyr Pro Tyr Ile Pro Pro Met Thr Glu Phe Phe Phe Asp Gly 
625                 630                 635                 640 


Thr Ser Asp Ile Thr Ile Phe Pro Pro Pro Ile Ser Val Glu Pro Val 
                645                 650                 655     


Glu Val Asp Phe Gly Ala Cys Pro Gly Pro Glu Ala Pro Asn Pro Val 
            660                 665                 670         


Pro Leu Cys Leu Met Asn His Thr Lys Gly Lys Ile Met Val Val Trp 
        675                 680                 685             


Thr Arg Arg Ser Asp Cys Pro Phe Trp Val Thr Pro Glu Ser Cys Asp 
    690                 695                 700                 


Val Pro Pro Leu Lys Ser Met Ala Met Arg Leu His Phe Gln Pro Pro 
705                 710                 715                 720 


His Pro Asn Cys Leu Tyr Thr Val Glu Leu Glu Ala Phe Ala Ile Tyr 
                725                 730                 735     


Lys Val Leu Gln Ser Tyr Ser Asn Ile Glu Glu Asp Cys Thr Met Cys 
            740                 745                 750         


Pro Ser Trp Cys Leu Thr Val Arg Ala Arg Gly His Ser Tyr Phe Ala 
        755                 760                 765             


Gly Phe Glu His His Ile Pro Gln Tyr Ser Leu Asp Val Pro Lys Leu 
    770                 775                 780                 


Phe Pro Ala Val Ser Ser Gly Glu Pro Thr Tyr Arg Ser Leu Leu Leu 
785                 790                 795                 800 


Val Asn Lys Asp Cys Lys Leu Leu Thr Phe Ser Leu Ala Pro Gln Arg 
                805                 810                 815     


Gly Ser Asp Val Ile Leu Arg Pro Thr Ser Gly Leu Val Ala Pro Gly 
            820                 825                 830         


Ala His Gln Ile Ile Leu Ile Cys Thr Tyr Pro Glu Gly Ser Ser Trp 
        835                 840                 845             


Lys Gln His Thr Phe Tyr Leu Gln Cys Asn Ala Ser Pro Gln Tyr Leu 
    850                 855                 860                 


Lys Glu Val Ser Met Tyr Ser Arg Glu Glu Pro Leu Gln Leu Lys Leu 
865                 870                 875                 880 


Asp Thr His Lys Ser Leu Tyr Phe Lys Pro Thr Trp Val Gly Cys Ser 
                885                 890                 895     


Ser Thr Ser Pro Phe Thr Phe Arg Asn Pro Ser Arg Leu Pro Leu Gln 
            900                 905                 910         


Phe Glu Trp Arg Val Ser Glu Gln His Arg Lys Leu Leu Ala Val Gln 
        915                 920                 925             


Pro Ser Arg Gly Leu Ile Gln Pro Asn Glu Arg Leu Thr Leu Thr Trp 
    930                 935                 940                 


Thr Phe Ser Pro Leu Glu Glu Thr Lys Tyr Leu Phe Gln Val Gly Met 
945                 950                 955                 960 


Trp Val Trp Glu Ala Gly Leu Ser Pro Asn Ala Asn Pro Ala Ala Thr 
                965                 970                 975     


Thr His Tyr Met Leu Arg Leu Val Gly Val Gly Leu Thr Ser Ser Leu 
            980                 985                 990         


Ser Ala Lys Glu Lys Glu Leu Ala  Phe Gly Asn Val Leu  Val Asn Ser 
        995                 1000                 1005             


Lys Gln  Ser Arg Phe Leu Val  Leu Leu Asn Asp Gly  Asn Cys Thr 
    1010                 1015                 1020             


Leu Tyr  Tyr Arg Leu Tyr Leu  Glu Gln Gly Ser Pro  Glu Ala Val 
    1025                 1030                 1035             


Asp Asn  His Pro Leu Ala Leu  Gln Leu Asp Arg Thr  Glu Gly Ser 
    1040                 1045                 1050             


Met Pro  Pro Arg Ser Gln Asp  Thr Ile Cys Leu Thr  Ala Cys Pro 
    1055                 1060                 1065             


Lys Gln  Arg Ser Gln Tyr Ser  Trp Thr Ile Thr Tyr  Ser Leu Leu 
    1070                 1075                 1080             


Ser His  Arg Asp Asn Lys Ala  Gly Glu Lys Gln Glu  Leu Cys Cys 
    1085                 1090                 1095             


Val Ser  Leu Val Ala Val Tyr  Pro Leu Leu Ser Ile  Leu Asp Val 
    1100                 1105                 1110             


Ser Ser  Met Gly Ser Ala Glu  Gly Ile Thr Arg Lys  His Leu Trp 
    1115                 1120                 1125             


Arg Leu  Phe Ser Leu Asp Leu  Leu Asn Ser Tyr Leu  Glu Arg Asp 
    1130                 1135                 1140             


Pro Thr  Pro Cys Glu Leu Thr  Tyr Lys Val Pro Thr  Arg His Ser 
    1145                 1150                 1155             


Met Ser  Gln Ile Pro Pro Val  Leu Thr Pro Leu Arg  Leu Asp Phe 
    1160                 1165                 1170             


Asn Phe  Gly Ala Ala Pro Phe  Lys Ala Pro Pro Ser  Val Val Phe 
    1175                 1180                 1185             


Leu Ala  Leu Lys Asn Ser Gly  Val Val Ser Leu Asp  Trp Ala Phe 
    1190                 1195                 1200             


Leu Leu  Pro Ser Asp Gln Arg  Ile Asp Val Glu Leu  Trp Ala Glu 
    1205                 1210                 1215             


Gln Ala  Glu Leu Asn Ser Thr  Glu Leu His Gln Met  Arg Val Gln 
    1220                 1225                 1230             


Asp Asn  Cys Leu Phe Ser Ile  Ser Pro Lys Ala Gly  Ser Leu Ser 
    1235                 1240                 1245             


Pro Gly  Gln Glu Gln Met Val  Glu Leu Lys Tyr Ser  His Leu Phe 
    1250                 1255                 1260             


Ile Gly  Thr Asp His Leu Pro  Val Leu Phe Lys Val  Ser His Gly 
    1265                 1270                 1275             


Arg Glu  Ile Leu Leu Asn Phe  Ile Gly Val Thr Val  Lys Pro Glu 
    1280                 1285                 1290             


Gln Lys  Tyr Val His Phe Thr  Ser Thr Thr His Gln  Phe Ile Pro 
    1295                 1300                 1305             


Ile Pro  Ile Gly Asp Thr Leu  Pro Pro Arg Gln Ile  Tyr Glu Leu 
    1310                 1315                 1320             


Tyr Asn  Gly Gly Ser Val Pro  Val Thr Tyr Glu Val  Gln Thr Asp 
    1325                 1330                 1335             


Val Leu  Ser Gln Val Gln Glu  Lys Asn Phe Asp His  Pro Ile Phe 
    1340                 1345                 1350             


Cys Cys  Leu Asn Pro Lys Gly  Glu Ile Gln Pro Gly  Ser Thr Ala 
    1355                 1360                 1365             


Arg Val  Leu Trp Ile Phe Ser  Pro Ile Glu Ala Lys  Thr Tyr Thr 
    1370                 1375                 1380             


Val Asp  Val Pro Ile His Ile  Leu Gly Trp Asn Ser  Ala Leu Ile 
    1385                 1390                 1395             


His Phe  Gln Gly Val Gly Tyr  Asn Pro His Met Met  Gly Asp Thr 
    1400                 1405                 1410             


Ala Pro  Phe His Asn Ile Ser  Ser Trp Asp Asn Ser  Ser Ile His 
    1415                 1420                 1425             


Ser Arg  Leu Val Val Pro Gly  Gln Asn Val Phe Leu  Ser Gln Ser 
    1430                 1435                 1440             


His Ile  Ser Leu Gly Asn Ile  Pro Val Gln Ser Lys  Cys Ser Arg 
    1445                 1450                 1455             


Leu Leu  Phe Leu Asn Asn Ile  Ser Lys Asn Glu Glu  Ile Ala Phe 
    1460                 1465                 1470             


Ser Trp  Gln Pro Ser Pro Leu  Asp Phe Gly Glu Val  Ser Val Ser 
    1475                 1480                 1485             


Pro Met  Ile Gly Val Val Ala  Pro Glu Glu Thr Val  Pro Phe Val 
    1490                 1495                 1500             


Val Thr  Leu Arg Ala Ser Val  His Ala Ser Phe Tyr  Ser Ala Asp 
    1505                 1510                 1515             


Leu Val  Cys Lys Leu Tyr Ser  Gln Gln Leu Met Arg  Gln Tyr His 
    1520                 1525                 1530             


Lys Glu  Leu Gln Glu Trp Lys  Asp Glu Lys Val Arg  Gln Glu Val 
    1535                 1540                 1545             


Glu Phe  Thr Ile Thr Asp Met  Lys Val Lys Lys Arg  Thr Cys Cys 
    1550                 1555                 1560             


Thr Ala  Cys Glu Pro Ala Arg  Lys Tyr Lys Thr Leu  Pro Pro Ile 
    1565                 1570                 1575             


Lys Asn  Gln Gln Ser Val Ser  Arg Pro Ala Ser Trp  Lys Leu Gln 
    1580                 1585                 1590             


Thr Pro  Lys Glu Glu Val Ser  Trp Pro Cys Pro Gln  Pro Pro Ser 
    1595                 1600                 1605             


Pro Gly  Met Leu Cys Leu Gly  Leu Thr Ala Arg Ala  His Ala Thr 
    1610                 1615                 1620             


Asp Tyr  Phe Leu Ala Asn Phe  Phe Ser Glu Phe Pro  Cys His Phe 
    1625                 1630                 1635             


Leu His  Arg Glu Leu Pro Lys  Arg Lys Ala Pro Arg  Glu Glu Ser 
    1640                 1645                 1650             


Glu Thr  Ser Glu Glu Lys Ser  Pro Asn Lys Trp Gly  Pro Val Ser 
    1655                 1660                 1665             


Lys Gln  Lys Lys Gln Leu Leu  Val Asp Ile Leu Thr  Thr Ile Ile 
    1670                 1675                 1680             


Arg Gly  Leu Leu Glu Asp Lys  Asn Phe His Glu Ala  Val Asp Gln 
    1685                 1690                 1695             


Ser Leu  Val Glu Gln Val Pro  Tyr Phe Arg Gln Phe  Trp Asn Glu 
    1700                 1705                 1710             


Gln Ser  Thr Lys Phe Met Asp  Gln Lys Asn Ser Leu  Tyr Leu Met 
    1715                 1720                 1725             


Pro Ile  Leu Pro Val Pro Ser  Ser Ser Trp Glu Asp  Gly Lys Gly 
    1730                 1735                 1740             


Lys Gln  Pro Lys Glu Asp Arg  Pro Glu His Tyr Pro  Gly Leu Gly 
    1745                 1750                 1755             


Lys Lys  Glu Glu Gly Glu Glu  Glu Lys Gly Glu Glu  Glu Glu Glu 
    1760                 1765                 1770             


Glu Leu  Glu Glu Glu Glu Glu  Glu Glu Glu Glu Thr  Glu Glu Glu 
    1775                 1780                 1785             


Glu Leu  Gly Lys Glu Glu Ile  Glu Glu Lys Glu Glu  Glu Arg Asp 
    1790                 1795                 1800             


Glu Lys  Glu Glu Lys Val Ser  Trp Ala Gly Ile Gly  Pro Thr Pro 
    1805                 1810                 1815             


Gln Pro  Glu Ser Gln Glu Ser  Met Gln Trp Gln Trp  Gln Gln Gln 
    1820                 1825                 1830             


Leu Asn  Val Met Val Lys Glu  Glu Gln Glu Gln Asp  Glu Lys Glu 
    1835                 1840                 1845             


Ala Ile  Arg Arg Leu Pro Ala  Phe Ala Asn Leu Gln  Glu Ala Leu 
    1850                 1855                 1860             


Leu Glu  Asn Met Ile Gln Asn  Ile Leu Val Glu Ala  Ser Arg Gly 
    1865                 1870                 1875             


Glu Val  Val Leu Thr Ser Arg  Pro Arg Val Ile Ala  Leu Pro Pro 
    1880                 1885                 1890             


Phe Cys  Val Pro Arg Ser Leu  Thr Pro Asp Thr Leu  Leu Pro Thr 
    1895                 1900                 1905             


Gln Gln  Ala Glu Val Leu His  Pro Val Val Pro Leu  Pro Thr Asp 
    1910                 1915                 1920             


Leu Pro  
    1925 


<210>  2663
<211>  114
<212>  PRT
<213>  Homo Sapiens

<400>  2663

Met Met Leu Thr Gln Ala Pro Ser Ser Val Val Arg Ser Arg Asn Ser 
1               5                   10                  15      


Arg Asn His Thr Val Asn Ser Gly Gly Ser Cys Leu Ser Ala Ser Thr 
            20                  25                  30          


Val Ala Ile Pro Ala Ile Asn Asp Ser Ser Ala Ala Met Ser Ala Cys 
        35                  40                  45              


Ser Thr Ile Ser Ala Gln Pro Ala Ser Ser Met Asp Thr Gln Met His 
    50                  55                  60                  


Ser Pro Lys Lys Gln Glu Arg Val Asn Lys Arg Val Ile Trp Gly Ile 
65                  70                  75                  80  


Glu Val Ala Glu Glu Leu His Trp Lys Gly Trp Glu Leu Gly Lys Glu 
                85                  90                  95      


Thr Thr Arg Asn Leu Val Leu Lys Asn Arg Ser Leu Lys Leu Gln Lys 
            100                 105                 110         


Met Lys 
        


<210>  2664
<211>  117
<212>  PRT
<213>  Homo Sapiens

<400>  2664

Met Met Leu Thr Gln Ala Pro Ser Ser Val Val Arg Ser Arg Asn Ser 
1               5                   10                  15      


Arg Asn His Thr Val Asn Ser Gly Gly Ser Cys Leu Ser Ala Ser Thr 
            20                  25                  30          


Val Ala Ile Pro Ala Ile Asn Asp Ser Ser Ala Ala Met Ser Ala Cys 
        35                  40                  45              


Ser Thr Ile Ser Ala Gln Pro Ala Ser Ser Met Asp Thr Gln Met His 
    50                  55                  60                  


Ser Pro Lys Lys Gln Glu Arg Val Asn Lys Arg Val Ile Trp Gly Ile 
65                  70                  75                  80  


Glu Val Ala Glu Glu Leu His Trp Lys Gly Trp Glu Leu Gly Lys Glu 
                85                  90                  95      


Thr Thr Arg Asn Leu Val Leu Lys Asn Arg Ser Leu Lys Leu Gln Lys 
            100                 105                 110         


Met Lys Tyr Arg Pro 
        115         


<210>  2665
<211>  730
<212>  PRT
<213>  Homo Sapiens

<400>  2665

Met Met Leu Thr Gln Ala Pro Ser Ser Val Val Arg Ser Arg Asn Ser 
1               5                   10                  15      


Arg Asn His Thr Val Asn Ser Gly Gly Ser Cys Leu Ser Ala Ser Thr 
            20                  25                  30          


Val Ala Ile Pro Ala Ile Asn Asp Ser Ser Ala Ala Met Ser Ala Cys 
        35                  40                  45              


Ser Thr Ile Ser Ala Gln Pro Ala Ser Ser Met Asp Thr Gln Met His 
    50                  55                  60                  


Ser Pro Lys Lys Gln Glu Arg Val Asn Lys Arg Val Ile Trp Gly Ile 
65                  70                  75                  80  


Glu Val Ala Glu Glu Leu His Trp Lys Gly Trp Glu Leu Gly Lys Glu 
                85                  90                  95      


Thr Thr Arg Asn Leu Val Leu Lys Asn Arg Ser Leu Lys Leu Gln Lys 
            100                 105                 110         


Met Lys Tyr Arg Pro Pro Lys Thr Lys Phe Phe Phe Thr Val Ile Pro 
        115                 120                 125             


Gln Pro Ile Phe Leu Ser Pro Gly Ile Thr Leu Thr Leu Pro Ile Val 
    130                 135                 140                 


Phe Arg Pro Leu Glu Ala Lys Glu Tyr Met Asp Gln Leu Trp Phe Glu 
145                 150                 155                 160 


Lys Ala Glu Gly Met Phe Cys Val Gly Leu Arg Ala Thr Leu Pro Cys 
                165                 170                 175     


His Arg Leu Ile Cys Arg Pro Pro Ser Leu Gln Leu Pro Met Cys Ala 
            180                 185                 190         


Val Gly Asp Thr Thr Glu Ala Phe Phe Cys Leu Asp Asn Val Gly Asp 
        195                 200                 205             


Leu Pro Thr Phe Phe Thr Trp Glu Phe Ser Ser Pro Phe Gln Met Leu 
    210                 215                 220                 


Pro Ala Thr Gly Leu Leu Glu Pro Gly Gln Ala Ser Gln Ile Lys Val 
225                 230                 235                 240 


Thr Phe Gln Pro Leu Thr Ala Val Ile Tyr Glu Val Gln Ala Thr Cys 
                245                 250                 255     


Trp Tyr Gly Ala Gly Ser Arg Gln Arg Ser Ser Ile Gln Leu Gln Ala 
            260                 265                 270         


Val Ala Lys Cys Ala Gln Leu Leu Val Ser Ile Lys His Lys Cys Pro 
        275                 280                 285             


Glu Asp Gln Asp Ala Glu Gly Phe Gln Lys Leu Leu Tyr Phe Gly Ser 
    290                 295                 300                 


Val Ala Val Gly Cys Thr Ser Glu Arg Gln Ile Arg Leu His Asn Pro 
305                 310                 315                 320 


Ser Ala Val Asn Ala Pro Phe Arg Ile Glu Ile Ser Pro Asp Glu Leu 
                325                 330                 335     


Ala Glu Asp Gln Ala Phe Ser Cys Pro Thr Ala His Gly Ile Val Leu 
            340                 345                 350         


Pro Gly Glu Lys Lys Cys Val Ser Val Phe Phe His Pro Lys Thr Leu 
        355                 360                 365             


Asp Thr Arg Thr Val Asp Tyr Cys Ser Ile Met Pro Ser Gly Cys Ala 
    370                 375                 380                 


Ser Lys Thr Leu Leu Lys Val Val Gly Phe Cys Arg Gly Pro Ala Val 
385                 390                 395                 400 


Ser Leu Gln His Tyr Cys Val Asn Phe Ser Trp Val Asn Leu Gly Glu 
                405                 410                 415     


Arg Ser Glu Gln Pro Leu Trp Ile Glu Asn Gln Ser Asp Cys Thr Ala 
            420                 425                 430         


His Phe Gln Phe Ala Ile Asp Cys Leu Glu Ser Val Phe Thr Ile Arg 
        435                 440                 445             


Pro Ala Phe Gly Thr Leu Val Gly Lys Ala Arg Met Thr Leu His Cys 
    450                 455                 460                 


Ala Phe Gln Pro Thr His Pro Ile Ile Cys Phe Arg Arg Val Ala Cys 
465                 470                 475                 480 


Leu Ile His His Gln Asp Pro Leu Phe Leu Asp Leu Met Gly Thr Cys 
                485                 490                 495     


His Ser Asp Ser Thr Lys Pro Ala Ile Leu Lys Pro Gln His Leu Thr 
            500                 505                 510         


Trp Tyr Arg Thr His Leu Ala Arg Gly Leu Thr Leu Tyr Pro Pro Asp 
        515                 520                 525             


Ile Leu Asp Ala Met Leu Lys Glu Lys Lys Leu Ala Gln Asp Gln Asn 
    530                 535                 540                 


Gly Ala Leu Met Ile Pro Ile Gln Asp Leu Glu Asp Met Pro Ala Pro 
545                 550                 555                 560 


Gln Tyr Pro Tyr Ile Pro Pro Met Thr Glu Phe Phe Phe Asp Gly Thr 
                565                 570                 575     


Ser Asp Ile Thr Ile Phe Pro Pro Pro Ile Ser Val Glu Pro Val Glu 
            580                 585                 590         


Val Asp Phe Gly Ala Cys Pro Gly Pro Glu Ala Pro Asn Pro Val Pro 
        595                 600                 605             


Leu Cys Leu Met Asn His Thr Lys Gly Lys Ile Met Val Val Trp Thr 
    610                 615                 620                 


Arg Arg Ser Asp Cys Pro Phe Trp Val Thr Pro Glu Ser Cys Asp Val 
625                 630                 635                 640 


Pro Pro Leu Lys Ser Met Ala Met Arg Leu His Phe Gln Pro Pro His 
                645                 650                 655     


Pro Asn Cys Leu Tyr Thr Val Glu Leu Glu Ala Phe Ala Ile Tyr Lys 
            660                 665                 670         


Val Cys Ala Arg Asn Glu Arg Glu Glu Cys Gly Val Ser Ala Arg Ser 
        675                 680                 685             


Leu Ser Gly Leu Val Gly Trp Gln Glu Val Thr Glu Gly Ser Phe Arg 
    690                 695                 700                 


Leu His Pro Leu Arg Ala Arg Leu Ser Leu Gly Trp Thr Val Thr Pro 
705                 710                 715                 720 


Met Ser Leu Ser Pro Pro Lys Leu Leu Ala 
                725                 730 


<210>  2666
<211>  164
<212>  PRT
<213>  Homo Sapiens

<400>  2666

Met Met Leu Thr Gln Ala Pro Ser Ser Val Val Arg Ser Arg Asn Ser 
1               5                   10                  15      


Arg Asn His Thr Val Asn Ser Gly Gly Ser Cys Leu Ser Ala Ser Thr 
            20                  25                  30          


Val Ala Ile Pro Ala Ile Asn Asp Ser Ser Ala Ala Met Ser Ala Cys 
        35                  40                  45              


Ser Thr Ile Ser Ala Gln Pro Ala Ser Ser Met Asp Thr Gln Met His 
    50                  55                  60                  


Ser Pro Lys Lys Gln Glu Arg Val Asn Lys Arg Val Ile Trp Gly Ile 
65                  70                  75                  80  


Glu Val Ala Glu Glu Leu His Trp Lys Gly Trp Glu Leu Gly Lys Glu 
                85                  90                  95      


Thr Thr Arg Asn Leu Val Leu Lys Asn Arg Ser Leu Lys Leu Gln Lys 
            100                 105                 110         


Met Lys Tyr Arg Tyr Gln Tyr Lys Gly Ser Arg Thr Gln Cys His Ser 
        115                 120                 125             


Leu Glu Pro Arg Lys Gln Ala Leu Phe Lys Thr Lys Gln Asn Lys Gln 
    130                 135                 140                 


Lys Lys Pro Leu Thr Cys His Ile Lys Ala Ser Glu Cys Leu Lys Tyr 
145                 150                 155                 160 


Val Gln Tyr Glu 
                


<210>  2667
<211>  271
<212>  PRT
<213>  Homo Sapiens

<400>  2667

Met Thr Leu His Cys Ala Phe Gln Pro Thr His Pro Ile Ile Cys Phe 
1               5                   10                  15      


Arg Arg Val Ala Cys Leu Ile His His Gln Asp Pro Leu Phe Leu Asp 
            20                  25                  30          


Leu Met Gly Thr Cys His Ser Asp Ser Thr Lys Pro Ala Ile Leu Lys 
        35                  40                  45              


Pro Gln His Leu Thr Trp Tyr Arg Thr His Leu Ala Arg Gly Leu Thr 
    50                  55                  60                  


Leu Tyr Pro Pro Asp Ile Leu Asp Ala Met Leu Lys Glu Lys Lys Leu 
65                  70                  75                  80  


Ala Gln Asp Gln Asn Gly Ala Leu Met Ile Pro Ile Gln Asp Leu Glu 
                85                  90                  95      


Asp Met Pro Ala Pro Gln Tyr Pro Tyr Ile Pro Pro Met Thr Glu Phe 
            100                 105                 110         


Phe Phe Asp Gly Thr Ser Asp Ile Thr Ile Phe Pro Pro Pro Ile Ser 
        115                 120                 125             


Val Glu Pro Val Glu Val Asp Phe Gly Ala Cys Pro Gly Pro Glu Ala 
    130                 135                 140                 


Pro Asn Pro Val Pro Leu Cys Leu Met Asn His Thr Lys Gly Lys Ile 
145                 150                 155                 160 


Met Val Val Trp Thr Arg Arg Ser Asp Cys Pro Phe Trp Val Thr Pro 
                165                 170                 175     


Glu Ser Cys Asp Val Pro Pro Leu Lys Ser Met Ala Met Arg Leu His 
            180                 185                 190         


Phe Gln Pro Pro His Pro Asn Cys Leu Tyr Thr Val Glu Leu Glu Ala 
        195                 200                 205             


Phe Ala Ile Tyr Lys Val Cys Ala Arg Asn Glu Arg Glu Glu Cys Gly 
    210                 215                 220                 


Val Ser Ala Arg Ser Leu Ser Gly Leu Val Gly Trp Gln Glu Val Thr 
225                 230                 235                 240 


Glu Gly Ser Phe Arg Leu His Pro Leu Arg Ala Arg Leu Ser Leu Gly 
                245                 250                 255     


Trp Thr Val Thr Pro Met Ser Leu Ser Pro Pro Lys Leu Leu Ala 
            260                 265                 270     


<210>  2668
<211>  127
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2668

Xaa Lys Gln Glu Leu Cys Cys Val Ser Leu Val Ala Val Tyr Pro Leu 
1               5                   10                  15      


Leu Ser Ile Leu Asp Val Ser Ser Met Gly Ser Ala Glu Gly Ile Thr 
            20                  25                  30          


Arg Lys His Leu Trp Arg Leu Phe Ser Leu Asp Leu Leu Asn Ser Tyr 
        35                  40                  45              


Leu Glu Arg Asp Pro Thr Pro Cys Glu Leu Thr Tyr Lys Val Pro Thr 
    50                  55                  60                  


Arg His Ser Met Ser Gln Ile Pro Pro Val Leu Thr Pro Leu Arg Leu 
65                  70                  75                  80  


Asp Phe Asn Phe Gly Ala Ala Pro Phe Lys Ala Pro Pro Ser Val Val 
                85                  90                  95      


Phe Leu Ala Leu Lys Asn Ser Gly Val Val Ser Leu Asp Trp Tyr Gly 
            100                 105                 110         


Leu Lys Gly Ala Thr Gly Gly Pro Gly Arg Gln Val Pro Arg Gly 
        115                 120                 125         


<210>  2669
<211>  144
<212>  PRT
<213>  Homo Sapiens

<400>  2669

Met Gly Ser Asn Leu Ser Pro Gln Leu Cys Leu Met Pro Phe Ile Leu 
1               5                   10                  15      


Gly Leu Leu Ser Gly Gly Val Thr Thr Thr Pro Trp Ser Leu Ala Arg 
            20                  25                  30          


Pro Gln Gly Ser Cys Ser Leu Glu Gly Val Glu Ile Lys Gly Gly Ser 
        35                  40                  45              


Phe Arg Leu Leu Gln Glu Gly Gln Ala Leu Glu Tyr Val Cys Pro Ser 
    50                  55                  60                  


Gly Phe Tyr Pro Tyr Pro Val Gln Thr Arg Thr Cys Arg Ser Thr Gly 
65                  70                  75                  80  


Ser Trp Ser Thr Leu Lys Thr Gln Asp Gln Lys Thr Val Arg Lys Ala 
                85                  90                  95      


Glu Cys Arg Ala Ile His Cys Pro Arg Pro His Asp Phe Glu Asn Gly 
            100                 105                 110         


Glu Tyr Trp Pro Arg Ser Pro Tyr Tyr Asn Val Ser Asp Glu Ile Ser 
        115                 120                 125             


Phe His Cys Tyr Asp Gly Tyr Thr Leu Arg Gly Ser Ala Asn Arg Thr 
    130                 135                 140                 


<210>  2670
<211>  764
<212>  PRT
<213>  Homo Sapiens

<400>  2670

Met Gly Ser Asn Leu Ser Pro Gln Leu Cys Leu Met Pro Phe Ile Leu 
1               5                   10                  15      


Gly Leu Leu Ser Gly Gly Val Thr Thr Thr Pro Trp Ser Leu Ala Arg 
            20                  25                  30          


Pro Gln Gly Ser Cys Ser Leu Glu Gly Val Glu Ile Lys Gly Gly Ser 
        35                  40                  45              


Phe Arg Leu Leu Gln Glu Gly Gln Ala Leu Glu Tyr Val Cys Pro Ser 
    50                  55                  60                  


Gly Phe Tyr Pro Tyr Pro Val Gln Thr Arg Thr Cys Arg Ser Thr Gly 
65                  70                  75                  80  


Ser Trp Ser Thr Leu Lys Thr Gln Asp Gln Lys Thr Val Arg Lys Ala 
                85                  90                  95      


Glu Cys Arg Ala Ile His Cys Pro Arg Pro His Asp Phe Glu Asn Gly 
            100                 105                 110         


Glu Tyr Trp Pro Arg Ser Pro Tyr Tyr Asn Val Ser Asp Glu Ile Ser 
        115                 120                 125             


Phe His Cys Tyr Asp Gly Tyr Thr Leu Arg Gly Ser Ala Asn Arg Thr 
    130                 135                 140                 


Cys Gln Val Asn Gly Arg Trp Ser Gly Gln Thr Ala Ile Cys Asp Asn 
145                 150                 155                 160 


Gly Ala Gly Tyr Cys Ser Asn Pro Gly Ile Pro Ile Gly Thr Arg Lys 
                165                 170                 175     


Val Gly Ser Gln Tyr Arg Leu Glu Asp Ser Val Thr Tyr His Cys Ser 
            180                 185                 190         


Arg Gly Leu Thr Leu Arg Gly Ser Gln Arg Arg Thr Cys Gln Glu Gly 
        195                 200                 205             


Gly Ser Trp Ser Gly Thr Glu Pro Ser Cys Gln Asp Ser Phe Met Tyr 
    210                 215                 220                 


Asp Thr Pro Gln Glu Val Ala Glu Ala Phe Leu Ser Ser Leu Thr Glu 
225                 230                 235                 240 


Thr Ile Glu Gly Val Asp Ala Glu Asp Gly His Gly Pro Gly Glu Gln 
                245                 250                 255     


Gln Lys Arg Lys Ile Val Leu Asp Pro Ser Gly Ser Met Asn Ile Tyr 
            260                 265                 270         


Leu Val Leu Asp Gly Ser Asp Ser Ile Gly Ala Ser Asn Phe Thr Gly 
        275                 280                 285             


Ala Lys Lys Cys Leu Val Asn Leu Ile Glu Lys Val Ala Ser Tyr Gly 
    290                 295                 300                 


Val Lys Pro Arg Tyr Gly Leu Val Thr Tyr Ala Thr Tyr Pro Lys Ile 
305                 310                 315                 320 


Trp Val Lys Val Ser Glu Ala Asp Ser Ser Asn Ala Asp Trp Val Thr 
                325                 330                 335     


Lys Gln Leu Asn Glu Ile Asn Tyr Glu Asp His Lys Leu Lys Ser Gly 
            340                 345                 350         


Thr Asn Thr Lys Lys Ala Leu Gln Ala Val Tyr Ser Met Met Ser Trp 
        355                 360                 365             


Pro Asp Asp Val Pro Pro Glu Gly Trp Asn Arg Thr Arg His Val Ile 
    370                 375                 380                 


Ile Leu Met Thr Asp Gly Leu His Asn Met Gly Gly Asp Pro Ile Thr 
385                 390                 395                 400 


Val Ile Asp Glu Ile Arg Asp Leu Leu Tyr Ile Gly Lys Asp Arg Lys 
                405                 410                 415     


Asn Pro Arg Glu Asp Tyr Leu Asp Val Tyr Val Phe Gly Val Gly Pro 
            420                 425                 430         


Leu Val Asn Gln Val Asn Ile Asn Ala Leu Ala Ser Lys Lys Asp Asn 
        435                 440                 445             


Glu Gln His Val Phe Lys Val Lys Asp Met Glu Asn Leu Glu Asp Val 
    450                 455                 460                 


Phe Tyr Gln Met Ile Asp Glu Ser Gln Ser Leu Ser Leu Cys Gly Met 
465                 470                 475                 480 


Val Trp Glu His Arg Lys Gly Thr Asp Tyr His Lys Gln Pro Trp Gln 
                485                 490                 495     


Ala Lys Ile Ser Val Ile Arg Pro Ser Lys Gly His Glu Ser Cys Met 
            500                 505                 510         


Gly Ala Val Val Ser Glu Tyr Phe Val Leu Thr Ala Ala His Cys Phe 
        515                 520                 525             


Thr Val Asp Asp Lys Glu His Ser Ile Lys Val Ser Val Gly Gly Glu 
    530                 535                 540                 


Lys Arg Asp Leu Glu Ile Glu Val Val Leu Phe His Pro Asn Tyr Asn 
545                 550                 555                 560 


Ile Asn Gly Lys Lys Glu Ala Gly Ile Pro Glu Phe Tyr Asp Tyr Asp 
                565                 570                 575     


Val Ala Leu Ile Lys Leu Lys Asn Lys Leu Lys Tyr Gly Gln Thr Ile 
            580                 585                 590         


Arg Pro Ile Cys Leu Pro Cys Thr Glu Gly Thr Thr Arg Ala Leu Arg 
        595                 600                 605             


Leu Pro Pro Thr Thr Thr Cys Gln Gln Gln Lys Glu Glu Leu Leu Pro 
    610                 615                 620                 


Ala Gln Asp Ile Lys Ala Leu Phe Val Ser Glu Glu Glu Lys Lys Leu 
625                 630                 635                 640 


Thr Arg Lys Glu Val Tyr Ile Lys Asn Gly Asp Lys Lys Gly Ser Cys 
                645                 650                 655     


Glu Arg Asp Ala Gln Tyr Ala Pro Gly Tyr Asp Lys Val Lys Asp Ile 
            660                 665                 670         


Ser Glu Val Val Thr Pro Arg Phe Leu Cys Thr Gly Gly Val Ser Pro 
        675                 680                 685             


Tyr Ala Asp Pro Asn Thr Cys Arg Gly Asp Ser Gly Gly Pro Leu Ile 
    690                 695                 700                 


Val His Lys Arg Ser Arg Phe Ile Gln Val Gly Val Ile Ser Trp Gly 
705                 710                 715                 720 


Val Val Asp Val Cys Lys Asn Gln Lys Arg Gln Lys Gln Val Pro Ala 
                725                 730                 735     


His Ala Arg Asp Phe His Ile Asn Leu Phe Gln Val Leu Pro Trp Leu 
            740                 745                 750         


Lys Glu Lys Leu Gln Asp Glu Asp Leu Gly Phe Leu 
        755                 760                 


<210>  2671
<211>  86
<212>  PRT
<213>  Homo Sapiens

<400>  2671

Met Gly Ser Asn Leu Ser Pro Gln Leu Cys Leu Met Pro Phe Ile Leu 
1               5                   10                  15      


Gly Leu Leu Ser Gly Val Arg Val Ser Phe Trp Leu Leu Pro Val Pro 
            20                  25                  30          


Cys Ala Asp Thr Tyr Leu Gln Ile Tyr Gly Val Leu Glu His Pro Glu 
        35                  40                  45              


Asp Ser Arg Pro Lys Asp Cys Gln Glu Gly Arg Val Gln Ser Asn Pro 
    50                  55                  60                  


Leu Ser Lys Thr Thr Arg Leu Arg Glu Arg Gly Ile Leu Ala Pro Val 
65                  70                  75                  80  


Ser Leu Leu Gln Cys Glu 
                85      


<210>  2672
<211>  305
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2672

Xaa Asp Gly Leu His Asn Met Gly Gly Asp Pro Ile Thr Val Ile Asp 
1               5                   10                  15      


Glu Ile Arg Asp Leu Leu Tyr Ile Gly Lys Asp Arg Lys Asn Pro Arg 
            20                  25                  30          


Glu Asp Tyr Leu Asp Val Tyr Val Phe Gly Val Gly Pro Leu Val Asn 
        35                  40                  45              


Gln Val Asn Ile Asn Ala Leu Ala Ser Lys Lys Asp Asn Glu Gln His 
    50                  55                  60                  


Val Phe Lys Val Lys Asp Met Glu Asn Leu Glu Asp Val Phe Tyr Gln 
65                  70                  75                  80  


Met Ile Gly Gly Glu Lys Arg Asp Leu Glu Ile Glu Val Val Leu Phe 
                85                  90                  95      


His Pro Asn Tyr Asn Ile Asn Gly Lys Lys Glu Ala Gly Ile Pro Glu 
            100                 105                 110         


Phe Tyr Asp Tyr Asp Val Ala Leu Ile Lys Leu Lys Asn Lys Leu Lys 
        115                 120                 125             


Tyr Gly Gln Thr Ile Arg Pro Ile Cys Leu Pro Cys Thr Glu Gly Thr 
    130                 135                 140                 


Thr Arg Ala Leu Arg Leu Pro Pro Thr Thr Thr Cys Gln Gln Gln Lys 
145                 150                 155                 160 


Glu Glu Leu Leu Pro Ala Gln Asp Ile Lys Ala Leu Phe Val Ser Glu 
                165                 170                 175     


Glu Glu Lys Lys Leu Thr Arg Lys Glu Val Tyr Ile Lys Asn Gly Asp 
            180                 185                 190         


Lys Lys Gly Ser Cys Glu Arg Asp Ala Gln Tyr Ala Pro Gly Tyr Asp 
        195                 200                 205             


Lys Val Lys Asp Ile Ser Glu Val Val Thr Pro Arg Phe Leu Cys Thr 
    210                 215                 220                 


Gly Gly Val Ser Pro Tyr Ala Asp Pro Asn Thr Cys Arg Gly Asp Ser 
225                 230                 235                 240 


Gly Gly Pro Leu Ile Val His Lys Arg Ser Arg Phe Ile Gln Val Gly 
                245                 250                 255     


Val Ile Ser Trp Gly Val Val Asp Val Cys Lys Asn Gln Lys Arg Gln 
            260                 265                 270         


Lys Gln Val Pro Ala His Ala Arg Asp Phe His Ile Asn Leu Phe Gln 
        275                 280                 285             


Val Leu Pro Trp Leu Lys Glu Lys Leu Gln Asp Glu Asp Leu Gly Phe 
    290                 295                 300                 


Leu 
305 


<210>  2673
<211>  68
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2673

Xaa Pro Arg Phe Leu Cys Thr Gly Gly Val Ser Pro Tyr Ala Asp Pro 
1               5                   10                  15      


Asn Thr Cys Arg Gly Asp Ser Gly Gly Pro Leu Ile Val His Lys Arg 
            20                  25                  30          


Ser Arg Phe Ile Gln Val Ser Pro Pro Phe Pro Ile Trp Gly Asp Ala 
        35                  40                  45              


Lys Trp Ser Ala Trp Ala Pro Lys Gln Glu Ser Ser Met His Val Ala 
    50                  55                  60                  


Ser Asn Ser Arg 
65              


<210>  2674
<211>  148
<212>  PRT
<213>  Homo Sapiens

<400>  2674

Met Thr Trp Arg His His Val Arg Leu Leu Phe Thr Val Ser Leu Ala 
1               5                   10                  15      


Leu Gln Ile Ile Asn Leu Gly Asn Ser Tyr Gln Arg Glu Lys His Asn 
            20                  25                  30          


Gly Gly Arg Glu Glu Val Thr Lys Val Ala Thr Gln Lys His Arg Gln 
        35                  40                  45              


Ser Pro Leu Asn Trp Thr Ser Ser His Phe Gly Glu Val Thr Gly Ser 
    50                  55                  60                  


Ala Glu Gly Trp Gly Pro Glu Glu Pro Leu Pro Tyr Ser Arg Ala Phe 
65                  70                  75                  80  


Gly Glu Asp Pro Lys Asp Phe Leu Ala Ser His Ala His Gly Pro Ser 
                85                  90                  95      


Ala Gly Gly Ala Pro Ser Leu Leu Leu Leu Leu Pro Cys Ala Leu Leu 
            100                 105                 110         


His Arg Leu Leu Arg Pro Asp Ala Pro Ala His Pro Arg Ser Leu Val 
        115                 120                 125             


Pro Ser Val Leu Gln Arg Glu Arg Arg Pro Cys Gly Arg Pro Gly Leu 
    130                 135                 140                 


Gly His Arg Leu 
145             


<210>  2675
<211>  223
<212>  PRT
<213>  Homo Sapiens

<400>  2675

Met Thr Trp Arg His His Val Arg Leu Leu Phe Thr Val Ser Leu Ala 
1               5                   10                  15      


Leu Gln Ile Ile Asn Leu Gly Asn Ser Tyr Gln Arg Glu Lys His Asn 
            20                  25                  30          


Gly Gly Arg Glu Glu Val Thr Lys Val Ala Thr Gln Lys His Arg Gln 
        35                  40                  45              


Ser Pro Leu Asn Trp Thr Ser Ser His Phe Gly Glu Val Thr Gly Ser 
    50                  55                  60                  


Ala Glu Gly Trp Gly Pro Glu Glu Pro Leu Pro Tyr Ser Arg Ala Phe 
65                  70                  75                  80  


Gly Glu Gly Ala Ser Ala Arg Pro Arg Cys Cys Arg Asn Gly Gly Thr 
                85                  90                  95      


Cys Val Leu Gly Ser Phe Cys Val Cys Pro Ala His Phe Thr Gly Arg 
            100                 105                 110         


Tyr Cys Glu His Asp Gln Arg Arg Ser Glu Cys Gly Ala Leu Glu His 
        115                 120                 125             


Gly Ala Trp Thr Leu Arg Ala Cys His Leu Cys Arg Cys Ile Phe Gly 
    130                 135                 140                 


Ala Leu His Cys Leu Pro Leu Gln Thr Pro Asp Arg Cys Asp Pro Lys 
145                 150                 155                 160 


Asp Phe Leu Ala Ser His Ala His Gly Pro Ser Ala Gly Gly Ala Pro 
                165                 170                 175     


Ser Leu Leu Leu Leu Leu Pro Cys Ala Leu Leu His Arg Leu Leu Arg 
            180                 185                 190         


Pro Asp Ala Pro Ala His Pro Arg Ser Leu Val Pro Ser Val Leu Gln 
        195                 200                 205             


Arg Glu Arg Arg Pro Cys Gly Arg Pro Gly Leu Gly His Arg Leu 
    210                 215                 220             


<210>  2676
<211>  191
<212>  PRT
<213>  Homo Sapiens

<400>  2676

Met Thr Trp Arg His His Val Arg Leu Leu Phe Thr Val Ser Leu Ala 
1               5                   10                  15      


Leu Gln Ile Ile Asn Leu Gly Asn Ser Tyr Gln Arg Glu Lys His Asn 
            20                  25                  30          


Gly Gly Arg Glu Glu Val Thr Lys Val Ala Thr Gln Lys His Arg Gln 
        35                  40                  45              


Ser Pro Leu Asn Trp Thr Ser Ser His Phe Gly Glu Val Thr Gly Ser 
    50                  55                  60                  


Ala Glu Gly Trp Gly Pro Glu Glu Pro Leu Pro Tyr Ser Arg Ala Phe 
65                  70                  75                  80  


Gly Glu Val Asn Ala Ala Pro Trp Ser Thr Glu Pro Gly Pro Ser Ala 
                85                  90                  95      


Pro Ala Thr Ser Ala Gly Ala Ser Ser Gly Pro Cys Thr Ala Ser Pro 
            100                 105                 110         


Ser Arg Arg Leu Thr Ala Val Thr Arg Lys Thr Ser Trp Pro Pro Thr 
        115                 120                 125             


Leu Thr Gly Arg Ala Pro Gly Ala Arg Pro Ala Cys Tyr Ser Cys Cys 
    130                 135                 140                 


Pro Ala His Ser Cys Thr Ala Ser Cys Ala Arg Met Arg Pro Arg Thr 
145                 150                 155                 160 


Leu Gly Pro Trp Ser Leu Pro Ser Ser Ser Gly Ser Gly Ala Pro Ala 
                165                 170                 175     


Glu Gly Arg Asp Leu Gly Ile Ala Phe Asn Phe Leu Cys Cys Lys 
            180                 185                 190     


<210>  2677
<211>  148
<212>  PRT
<213>  Homo Sapiens

<400>  2677

Met Thr Trp Arg His His Val Arg Leu Leu Phe Thr Val Ser Leu Ala 
1               5                   10                  15      


Leu Gln Ile Ile Asn Leu Gly Asn Ser Tyr Gln Arg Glu Lys His Asn 
            20                  25                  30          


Gly Gly Arg Glu Glu Val Thr Lys Val Ala Thr Gln Lys His Arg Gln 
        35                  40                  45              


Ser Pro Leu Asn Trp Thr Ser Ser His Phe Gly Glu Val Thr Gly Ser 
    50                  55                  60                  


Ala Glu Gly Trp Gly Pro Glu Glu Pro Leu Pro Tyr Ser Trp Ala Phe 
65                  70                  75                  80  


Gly Glu Asp Pro Lys Asp Phe Leu Ala Ser His Ala His Gly Pro Ser 
                85                  90                  95      


Ala Gly Gly Ala Pro Ser Leu Leu Leu Leu Leu Pro Cys Ala Leu Leu 
            100                 105                 110         


His Arg Leu Leu Arg Pro Asp Ala Pro Ala His Pro Arg Ser Leu Val 
        115                 120                 125             


Pro Ser Val Leu Gln Arg Glu Arg Arg Pro Cys Gly Arg Pro Gly Leu 
    130                 135                 140                 


Gly His Arg Leu 
145             


<210>  2678
<211>  223
<212>  PRT
<213>  Homo Sapiens

<400>  2678

Met Thr Trp Arg His His Val Arg Leu Leu Phe Thr Val Ser Leu Ala 
1               5                   10                  15      


Leu Gln Ile Ile Asn Leu Gly Asn Ser Tyr Gln Arg Glu Lys His Asn 
            20                  25                  30          


Gly Gly Arg Glu Glu Val Thr Lys Val Ala Thr Gln Lys His Arg Gln 
        35                  40                  45              


Ser Pro Leu Asn Trp Thr Ser Ser His Phe Gly Glu Val Thr Gly Ser 
    50                  55                  60                  


Ala Glu Gly Trp Gly Pro Glu Glu Pro Leu Pro Tyr Ser Trp Ala Phe 
65                  70                  75                  80  


Gly Glu Gly Ala Ser Ala Arg Pro Arg Cys Cys Arg Asn Gly Gly Thr 
                85                  90                  95      


Cys Val Leu Gly Ser Phe Cys Val Cys Pro Ala His Phe Thr Gly Arg 
            100                 105                 110         


Tyr Cys Glu His Asp Gln Arg Arg Ser Glu Cys Gly Ala Leu Glu His 
        115                 120                 125             


Gly Ala Trp Thr Leu Arg Ala Cys His Leu Cys Arg Cys Ile Phe Gly 
    130                 135                 140                 


Ala Leu His Cys Leu Pro Leu Gln Thr Pro Asp Arg Cys Asp Pro Lys 
145                 150                 155                 160 


Asp Phe Leu Ala Ser His Ala His Gly Pro Ser Ala Gly Gly Ala Pro 
                165                 170                 175     


Ser Leu Leu Leu Leu Leu Pro Cys Ala Leu Leu His Arg Leu Leu Arg 
            180                 185                 190         


Pro Asp Ala Pro Ala His Pro Arg Ser Leu Val Pro Ser Val Leu Gln 
        195                 200                 205             


Arg Glu Arg Arg Pro Cys Gly Arg Pro Gly Leu Gly His Arg Leu 
    210                 215                 220             


<210>  2679
<211>  191
<212>  PRT
<213>  Homo Sapiens

<400>  2679

Met Thr Trp Arg His His Val Arg Leu Leu Phe Thr Val Ser Leu Ala 
1               5                   10                  15      


Leu Gln Ile Ile Asn Leu Gly Asn Ser Tyr Gln Arg Glu Lys His Asn 
            20                  25                  30          


Gly Gly Arg Glu Glu Val Thr Lys Val Ala Thr Gln Lys His Arg Gln 
        35                  40                  45              


Ser Pro Leu Asn Trp Thr Ser Ser His Phe Gly Glu Val Thr Gly Ser 
    50                  55                  60                  


Ala Glu Gly Trp Gly Pro Glu Glu Pro Leu Pro Tyr Ser Trp Ala Phe 
65                  70                  75                  80  


Gly Glu Val Asn Ala Ala Pro Trp Ser Thr Glu Pro Gly Pro Ser Ala 
                85                  90                  95      


Pro Ala Thr Ser Ala Gly Ala Ser Ser Gly Pro Cys Thr Ala Ser Pro 
            100                 105                 110         


Ser Arg Arg Leu Thr Ala Val Thr Arg Lys Thr Ser Trp Pro Pro Thr 
        115                 120                 125             


Leu Thr Gly Arg Ala Pro Gly Ala Arg Pro Ala Cys Tyr Ser Cys Cys 
    130                 135                 140                 


Pro Ala His Ser Cys Thr Ala Ser Cys Ala Arg Met Arg Pro Arg Thr 
145                 150                 155                 160 


Leu Gly Pro Trp Ser Leu Pro Ser Ser Ser Gly Ser Gly Ala Pro Ala 
                165                 170                 175     


Glu Gly Arg Asp Leu Gly Ile Ala Phe Asn Phe Leu Cys Cys Lys 
            180                 185                 190     


<210>  2680
<211>  253
<212>  PRT
<213>  Homo Sapiens

<400>  2680

Met His Ser Trp Glu Arg Leu Ala Val Leu Val Leu Leu Gly Ala Ala 
1               5                   10                  15      


Ala Cys Ala Ala Pro Pro Arg Gly Arg Ile Leu Gly Gly Arg Glu Ala 
            20                  25                  30          


Glu Ala His Ala Arg Pro Tyr Met Ala Ser Val Gln Leu Asn Gly Ala 
        35                  40                  45              


His Leu Cys Gly Gly Val Leu Val Ala Glu Gln Trp Val Leu Ser Ala 
    50                  55                  60                  


Ala His Cys Leu Glu Asp Ala Ala Asp Gly Lys Val Gln Val Leu Leu 
65                  70                  75                  80  


Gly Ala His Ser Leu Ser Gln Pro Glu Pro Ser Lys Arg Leu Tyr Asp 
                85                  90                  95      


Val Leu Arg Ala Val Pro His Pro Asp Ser Gln Pro Asp Thr Ile Asp 
            100                 105                 110         


His Asp Leu Leu Leu Leu Gln Leu Ser Glu Lys Ala Thr Leu Gly Pro 
        115                 120                 125             


Ala Val Arg Pro Leu Pro Trp Gln Arg Val Asp Arg Asp Val Ala Pro 
    130                 135                 140                 


Gly Thr Leu Cys Asp Val Ala Gly Trp Gly Ile Val Asn His Ala Gly 
145                 150                 155                 160 


Arg Arg Pro Asp Ser Leu Gln His Val Leu Leu Pro Val Leu Asp Arg 
                165                 170                 175     


Ala Thr Cys Asn Arg Arg Thr His His Asp Gly Ala Ile Thr Glu Arg 
            180                 185                 190         


Leu Met Cys Ala Glu Ser Asn Arg Arg Asp Ser Cys Lys Gly Asp Ser 
        195                 200                 205             


Gly Gly Pro Leu Val Cys Gly Gly Val Leu Glu Gly Val Val Thr Ser 
    210                 215                 220                 


Gly Ser Arg Val Cys Gly Asn Arg Lys Lys Pro Gly Ile Tyr Thr Arg 
225                 230                 235                 240 


Val Ala Ser Tyr Ala Ala Trp Ile Asp Ser Val Leu Ala 
                245                 250             


<210>  2681
<211>  260
<212>  PRT
<213>  Homo Sapiens

<400>  2681

Met His Ser Trp Glu Arg Leu Ala Val Leu Val Leu Leu Gly Ala Ala 
1               5                   10                  15      


Ala Cys Gly Glu Glu Ala Trp Ala Trp Ala Ala Pro Pro Arg Gly Arg 
            20                  25                  30          


Ile Leu Gly Gly Arg Glu Ala Glu Ala His Ala Arg Pro Tyr Met Ala 
        35                  40                  45              


Ser Val Gln Leu Asn Gly Ala His Leu Cys Gly Gly Val Leu Val Ala 
    50                  55                  60                  


Glu Gln Trp Val Leu Ser Ala Ala His Cys Leu Glu Asp Ala Ala Asp 
65                  70                  75                  80  


Gly Lys Val Gln Val Leu Leu Gly Ala His Ser Leu Ser Gln Pro Glu 
                85                  90                  95      


Pro Ser Lys Arg Leu Tyr Asp Val Leu Arg Ala Val Pro His Pro Asp 
            100                 105                 110         


Ser Gln Pro Asp Thr Ile Asp His Asp Leu Leu Leu Leu Gln Leu Ser 
        115                 120                 125             


Glu Lys Ala Thr Leu Gly Pro Ala Val Arg Pro Leu Pro Trp Gln Arg 
    130                 135                 140                 


Val Asp Arg Asp Val Ala Pro Gly Thr Leu Cys Asp Val Ala Gly Trp 
145                 150                 155                 160 


Gly Ile Val Asn His Ala Gly Arg Arg Pro Asp Ser Leu Gln His Val 
                165                 170                 175     


Leu Leu Pro Val Leu Asp Arg Ala Thr Cys Asn Arg Arg Thr His His 
            180                 185                 190         


Asp Gly Ala Ile Thr Glu Arg Leu Met Cys Ala Glu Ser Asn Arg Arg 
        195                 200                 205             


Asp Ser Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Cys Gly Gly Val 
    210                 215                 220                 


Leu Glu Gly Val Val Thr Ser Gly Ser Arg Val Cys Gly Asn Arg Lys 
225                 230                 235                 240 


Lys Pro Gly Ile Tyr Thr Arg Val Ala Ser Tyr Ala Ala Trp Ile Asp 
                245                 250                 255     


Ser Val Leu Ala 
            260 


<210>  2682
<211>  299
<212>  PRT
<213>  Homo Sapiens

<400>  2682

Met Glu Glu Phe Asp Ser Glu Asp Phe Ser Thr Ser Glu Glu Asp Glu 
1               5                   10                  15      


Asp Tyr Val Pro Ser Gly Gly Glu Tyr Ser Glu Asp Asp Val Asn Glu 
            20                  25                  30          


Leu Val Lys Glu Asp Glu Val Asp Gly Glu Glu Gln Thr Gln Lys Thr 
        35                  40                  45              


Gln Gly Lys Lys Arg Lys Ala Gln Ser Ile Pro Ala Arg Lys Arg Arg 
    50                  55                  60                  


Gln Gly Gly Leu Ser Leu Glu Glu Glu Glu Glu Glu Asp Ala Asn Ser 
65                  70                  75                  80  


Glu Ser Glu Gly Ser Ser Ser Glu Glu Glu Asp Asp Ala Ala Glu Gln 
                85                  90                  95      


Glu Lys Gly Ile Gly Ser Glu Asp Ala Arg Lys Lys Lys Glu Asp Glu 
            100                 105                 110         


Leu Trp Ala Ser Phe Leu Asn Asp Val Gly Pro Lys Ser Lys Val Pro 
        115                 120                 125             


Pro Ser Thr Gln Val Lys Lys Gly Glu Glu Thr Glu Glu Thr Ser Ser 
    130                 135                 140                 


Ser Lys Leu Leu Val Lys Ala Glu Glu Leu Glu Lys Pro Lys Glu Thr 
145                 150                 155                 160 


Glu Lys Val Lys Ile Thr Lys Val Phe Asp Phe Ala Gly Glu Glu Val 
                165                 170                 175     


Arg Val Thr Lys Glu Val Asp Ala Thr Ser Lys Glu Ala Lys Ser Phe 
            180                 185                 190         


Phe Lys Gln Asn Glu Lys Glu Lys Pro Gln Ala Asn Val Pro Ser Ala 
        195                 200                 205             


Leu Pro Ser Leu Pro Ala Gly Ser Gly Leu Lys Arg Ser Ser Gly Met 
    210                 215                 220                 


Ser Ser Leu Leu Gly Lys Ile Gly Ala Lys Lys Gln Lys Met Ser Thr 
225                 230                 235                 240 


Leu Glu Lys Ser Lys Leu Asp Trp Glu Ser Phe Lys Glu Glu Glu Gly 
                245                 250                 255     


Ile Gly Glu Glu Leu Ala Ile His Asn Arg Gly Lys Glu Gly Tyr Ile 
            260                 265                 270         


Glu Arg Lys Ala Phe Leu Asp Arg Val Asp His Arg Gln Phe Glu Ile 
        275                 280                 285             


Glu Arg Asp Leu Arg Leu Ser Lys Met Lys Pro 
    290                 295                 


<210>  2683
<211>  50
<212>  PRT
<213>  Homo Sapiens

<400>  2683

Met Ser Arg Arg Pro Ala Tyr Cys Ser Leu Gln Phe Leu Gly Ser Ser 
1               5                   10                  15      


Asp Pro Pro Ala Ser Ala Ser Pro Val Asp Gly Thr Thr Gly Gly Glu 
            20                  25                  30          


Tyr Ser Glu Asp Asp Val Asn Glu Leu Val Lys Glu Asp Glu Val Asp 
        35                  40                  45              


Gly Glu 
    50  


<210>  2684
<211>  19
<212>  PRT
<213>  Homo Sapiens

<400>  2684

Gln Ala Asn Val Pro Ser Ala Leu Pro Ser Leu Pro Ala Gly Ser Gly 
1               5                   10                  15      


Cys Val Ile 
            


<210>  2685
<211>  17
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2685

Xaa Ala Leu Pro Ser Leu Pro Ala Gly Ser Gly Lys Lys Lys Phe Asp 
1               5                   10                  15      


Ala 
    


<210>  2686
<211>  385
<212>  PRT
<213>  Homo Sapiens

<400>  2686

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Glu Ile 
    130                 135                 140                 


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
145                 150                 155                 160 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
                165                 170                 175     


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
            180                 185                 190         


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
        195                 200                 205             


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
    210                 215                 220                 


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
225                 230                 235                 240 


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
                245                 250                 255     


Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
            260                 265                 270         


His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
        275                 280                 285             


Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
    290                 295                 300                 


Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
305                 310                 315                 320 


Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
                325                 330                 335     


Asn His Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
            340                 345                 350         


His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
        355                 360                 365             


Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Ser Phe Thr 
    370                 375                 380                 


Leu 
385 


<210>  2687
<211>  1231
<212>  PRT
<213>  Homo Sapiens

<400>  2687

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 


Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     


His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         


Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             


Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 


Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 


Asn His Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     


His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         


Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             


Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 


Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 


Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     


Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         


Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             


Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 


Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 


Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     


His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         


Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             


Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 


Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 


Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     


Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         


Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             


Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu 
    690                 695                 700                 


Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser 
705                 710                 715                 720 


Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly 
                725                 730                 735     


Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys 
            740                 745                 750         


Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys 
        755                 760                 765             


Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys 
    770                 775                 780                 


Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu 
785                 790                 795                 800 


Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln 
                805                 810                 815     


Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly 
            820                 825                 830         


Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly 
        835                 840                 845             


Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys 
    850                 855                 860                 


Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr 
865                 870                 875                 880 


Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys 
                885                 890                 895     


Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu 
            900                 905                 910         


Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly 
        915                 920                 925             


Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His 
    930                 935                 940                 


Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe 
945                 950                 955                 960 


Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu 
                965                 970                 975     


Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu 
            980                 985                 990         


Pro Ser Phe Glu Asn Ala Ile Pro  Met Gly Glu Lys Lys  Asp Val Tyr 
        995                 1000                 1005             


Lys Ala  Gly Glu Gln Val Thr  Tyr Thr Cys Ala Thr  Tyr Tyr Lys 
    1010                 1015                 1020             


Met Asp  Gly Ala Ser Asn Val  Thr Cys Ile Asn Ser  Arg Trp Thr 
    1025                 1030                 1035             


Gly Arg  Pro Thr Cys Arg Asp  Thr Ser Cys Val Asn  Pro Pro Thr 
    1040                 1045                 1050             


Val Gln  Asn Ala Tyr Ile Val  Ser Arg Gln Met Ser  Lys Tyr Pro 
    1055                 1060                 1065             


Ser Gly  Glu Arg Val Arg Tyr  Gln Cys Arg Ser Pro  Tyr Glu Met 
    1070                 1075                 1080             


Phe Gly  Asp Glu Glu Val Met  Cys Leu Asn Gly Asn  Trp Thr Glu 
    1085                 1090                 1095             


Pro Pro  Gln Cys Lys Asp Ser  Thr Gly Lys Cys Gly  Pro Pro Pro 
    1100                 1105                 1110             


Pro Ile  Asp Asn Gly Asp Ile  Thr Ser Phe Pro Leu  Ser Val Tyr 
    1115                 1120                 1125             


Ala Pro  Ala Ser Ser Val Glu  Tyr Gln Cys Gln Asn  Leu Tyr Gln 
    1130                 1135                 1140             


Leu Glu  Gly Asn Lys Arg Ile  Thr Cys Arg Asn Gly  Gln Trp Ser 
    1145                 1150                 1155             


Glu Pro  Pro Lys Cys Leu His  Pro Cys Val Ile Ser  Arg Glu Ile 
    1160                 1165                 1170             


Met Glu  Asn Tyr Asn Ile Ala  Leu Arg Trp Thr Ala  Lys Gln Lys 
    1175                 1180                 1185             


Leu Tyr  Ser Arg Thr Gly Glu  Ser Val Glu Phe Val  Cys Lys Arg 
    1190                 1195                 1200             


Gly Tyr  Arg Leu Ser Ser Arg  Ser His Thr Leu Arg  Thr Thr Cys 
    1205                 1210                 1215             


Trp Asp  Gly Lys Leu Glu Tyr  Pro Thr Cys Ala Lys  Arg 
    1220                 1225                 1230     


<210>  2688
<211>  449
<212>  PRT
<213>  Homo Sapiens

<400>  2688

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 


Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     


His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         


Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             


Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 


Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 


Asn His Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     


His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         


Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Ser Phe Thr 
        435                 440                 445             


Leu 
    


<210>  2689
<211>  271
<212>  PRT
<213>  Homo Sapiens

<400>  2689

Met Trp Leu Leu Val Ser Val Ile Leu Ile Ser Arg Ile Ser Ser Val 
1               5                   10                  15      


Gly Gly Glu Ala Thr Phe Cys Asp Phe Pro Lys Ile Asn His Gly Ile 
            20                  25                  30          


Leu Tyr Asp Glu Glu Lys Tyr Lys Pro Phe Ser Gln Val Pro Thr Gly 
        35                  40                  45              


Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys 
    50                  55                  60                  


Ser Phe Trp Thr Arg Ile Thr Cys Thr Glu Glu Gly Trp Ser Pro Thr 
65                  70                  75                  80  


Pro Lys Cys Leu Arg Leu Cys Phe Phe Pro Phe Val Glu Asn Gly His 
                85                  90                  95      


Ser Glu Ser Ser Gly Gln Thr His Leu Glu Gly Asp Thr Val Gln Ile 
            100                 105                 110         


Ile Cys Asn Thr Gly Tyr Arg Leu Gln Asn Asn Glu Asn Asn Ile Ser 
        115                 120                 125             


Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser Thr Asp 
    130                 135                 140                 


Ser Thr Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile 
145                 150                 155                 160 


Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr 
                165                 170                 175     


Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys 
            180                 185                 190         


Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val 
        195                 200                 205             


Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr 
    210                 215                 220                 


Ala Lys Gln Lys Leu Tyr Leu Arg Thr Gly Glu Ser Ala Glu Phe Val 
225                 230                 235                 240 


Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr 
                245                 250                 255     


Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg 
            260                 265                 270     


<210>  2690
<211>  330
<212>  PRT
<213>  Homo Sapiens

<400>  2690

Met Trp Leu Leu Val Ser Val Ile Leu Ile Ser Arg Ile Ser Ser Val 
1               5                   10                  15      


Gly Gly Glu Ala Thr Phe Cys Asp Phe Pro Lys Ile Asn His Gly Ile 
            20                  25                  30          


Leu Tyr Asp Glu Glu Lys Tyr Lys Pro Phe Ser Gln Val Pro Thr Gly 
        35                  40                  45              


Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys 
    50                  55                  60                  


Ser Phe Trp Thr Arg Ile Thr Cys Thr Glu Glu Gly Trp Ser Pro Thr 
65                  70                  75                  80  


Pro Lys Cys Leu Arg Leu Cys Phe Phe Pro Phe Val Glu Asn Gly His 
                85                  90                  95      


Ser Glu Ser Ser Gly Gln Thr His Leu Glu Gly Asp Thr Val Gln Ile 
            100                 105                 110         


Ile Cys Asn Thr Gly Tyr Arg Leu Gln Asn Asn Glu Asn Asn Ile Ser 
        115                 120                 125             


Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser Thr Asp 
    130                 135                 140                 


Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala His Ile Leu Ser 
145                 150                 155                 160 


Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Glu Cys 
                165                 170                 175     


Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn 
            180                 185                 190         


Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys 
        195                 200                 205             


Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu 
    210                 215                 220                 


Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu 
225                 230                 235                 240 


Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp 
                245                 250                 255     


Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile 
            260                 265                 270         


Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu 
        275                 280                 285             


Tyr Leu Arg Thr Gly Glu Ser Ala Glu Phe Val Cys Lys Arg Gly Tyr 
    290                 295                 300                 


Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly 
305                 310                 315                 320 


Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg 
                325                 330 


<210>  2691
<211>  270
<212>  PRT
<213>  Homo Sapiens

<400>  2691

Met Trp Leu Leu Val Ser Val Ile Leu Ile Ser Arg Ile Ser Ser Val 
1               5                   10                  15      


Gly Gly Glu Ala Met Phe Cys Asp Phe Pro Lys Ile Asn His Gly Ile 
            20                  25                  30          


Leu Tyr Asp Glu Glu Lys Tyr Lys Pro Phe Ser Gln Val Pro Thr Gly 
        35                  40                  45              


Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys 
    50                  55                  60                  


Ser Phe Trp Thr Arg Ile Thr Cys Ala Glu Glu Gly Trp Ser Pro Thr 
65                  70                  75                  80  


Pro Lys Cys Leu Arg Leu Cys Phe Phe Pro Phe Val Glu Asn Gly His 
                85                  90                  95      


Ser Glu Ser Ser Gly Gln Thr His Leu Glu Gly Asp Thr Val Gln Ile 
            100                 105                 110         


Ile Cys Asn Thr Gly Tyr Arg Leu Gln Asn Asn Glu Asn Asn Ile Ser 
        115                 120                 125             


Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser Thr Ile 
    130                 135                 140                 


Ser Ala Glu Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile 
145                 150                 155                 160 


Thr Ser Phe Leu Leu Ser Val Tyr Ala Pro Gly Ser Ser Val Glu Tyr 
                165                 170                 175     


Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Asn Gln Ile Thr Cys 
            180                 185                 190         


Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu Asp Pro Cys Val 
        195                 200                 205             


Ile Ser Gln Glu Ile Met Glu Lys Tyr Asn Ile Lys Leu Lys Trp Thr 
    210                 215                 220                 


Asn Gln Gln Lys Leu Tyr Ser Arg Thr Gly Asp Ile Val Glu Phe Val 
225                 230                 235                 240 


Cys Lys Ser Gly Tyr His Pro Thr Lys Ser His Ser Phe Arg Ala Met 
                245                 250                 255     


Cys Gln Asn Gly Lys Leu Val Tyr Pro Ser Cys Glu Glu Lys 
            260                 265                 270 


<210>  2692
<211>  254
<212>  PRT
<213>  Homo Sapiens

<400>  2692

Met Trp Leu Leu Val Ser Val Ile Leu Ile Ser Arg Ile Ser Ser Val 
1               5                   10                  15      


Gly Gly Glu Ala Met Phe Cys Asp Phe Pro Lys Ile Asn His Gly Ile 
            20                  25                  30          


Leu Tyr Asp Glu Glu Lys Tyr Lys Pro Phe Ser Gln Val Pro Thr Gly 
        35                  40                  45              


Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys 
    50                  55                  60                  


Ser Phe Trp Thr Arg Ile Thr Cys Ala Glu Glu Gly Trp Ser Pro Thr 
65                  70                  75                  80  


Pro Lys Cys Leu Arg Gln Thr His Leu Glu Gly Asp Thr Val Gln Ile 
                85                  90                  95      


Ile Cys Asn Thr Gly Tyr Arg Leu Gln Asn Asn Glu Asn Asn Ile Ser 
            100                 105                 110         


Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser Thr Ile 
        115                 120                 125             


Ser Ala Glu Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile 
    130                 135                 140                 


Thr Ser Phe Leu Leu Ser Val Tyr Ala Pro Gly Ser Ser Val Glu Tyr 
145                 150                 155                 160 


Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Asn Gln Ile Thr Cys 
                165                 170                 175     


Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu Asp Pro Cys Val 
            180                 185                 190         


Ile Ser Gln Glu Ile Met Glu Lys Tyr Asn Ile Lys Leu Lys Trp Thr 
        195                 200                 205             


Asn Gln Gln Lys Leu Tyr Ser Arg Thr Gly Asp Ile Val Glu Phe Val 
    210                 215                 220                 


Cys Lys Ser Gly Tyr His Pro Thr Lys Ser His Ser Phe Arg Ala Met 
225                 230                 235                 240 


Cys Gln Asn Gly Lys Leu Val Tyr Pro Ser Cys Glu Glu Lys 
                245                 250                 


<210>  2693
<211>  269
<212>  PRT
<213>  Homo Sapiens

<400>  2693

Met Leu Leu Leu Ile Asn Val Ile Leu Thr Leu Trp Val Ser Cys Ala 
1               5                   10                  15      


Asn Gly Gln Val Lys Pro Cys Asp Phe Pro Asp Ile Lys His Gly Gly 
            20                  25                  30          


Leu Phe His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly 
        35                  40                  45              


Lys Tyr Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly 
    50                  55                  60                  


Ser Tyr Trp Asp Tyr Ile His Cys Thr Gln Asn Gly Trp Ser Pro Ala 
65                  70                  75                  80  


Val Pro Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr 
                85                  90                  95      


Asn Gln Asn Tyr Gly Arg Lys Phe Val Gln Gly Asn Ser Thr Glu Val 
            100                 105                 110         


Ala Cys His Pro Gly Tyr Gly Leu Pro Lys Ala Gln Thr Thr Val Thr 
        115                 120                 125             


Cys Thr Glu Lys Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Asn 
    130                 135                 140                 


Ser Ser Glu Lys Cys Gly Pro Pro Pro Pro Ile Ser Asn Gly Asp Thr 
145                 150                 155                 160 


Thr Ser Phe Leu Leu Lys Val Tyr Val Pro Gln Ser Arg Val Glu Tyr 
                165                 170                 175     


Gln Cys Gln Pro Tyr Tyr Glu Leu Gln Gly Ser Asn Tyr Val Thr Cys 
            180                 185                 190         


Ser Asn Gly Glu Trp Ser Glu Pro Pro Arg Cys Ile His Pro Cys Ile 
        195                 200                 205             


Ile Thr Glu Glu Asn Met Asn Lys Asn Asn Ile Lys Leu Lys Gly Arg 
    210                 215                 220                 


Ser Asp Arg Lys Tyr Tyr Ala Lys Thr Gly Asp Thr Ile Glu Phe Met 
225                 230                 235                 240 


Cys Lys Leu Gly Tyr Asn Ala Asn Thr Ser Ile Leu Ser Phe Gln Ala 
                245                 250                 255     


Val Cys Arg Glu Gly Ile Val Glu Tyr Pro Arg Cys Glu 
            260                 265                 


<210>  2694
<211>  195
<212>  PRT
<213>  Homo Sapiens

<400>  2694

Met Leu Leu Leu Ile Asn Val Ile Leu Thr Leu Trp Val Ser Cys Ala 
1               5                   10                  15      


Asn Gly Gln Val Lys Pro Cys Asp Phe Pro Asp Ile Lys His Gly Gly 
            20                  25                  30          


Leu Phe His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly 
        35                  40                  45              


Lys Tyr Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly 
    50                  55                  60                  


Ser Tyr Trp Asp Tyr Ile His Cys Thr Gln Asn Gly Trp Ser Pro Ala 
65                  70                  75                  80  


Val Pro Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr 
                85                  90                  95      


Asn Gln Asn Tyr Gly Arg Lys Phe Val Gln Gly Asn Ser Thr Glu Val 
            100                 105                 110         


Ala Cys His Pro Gly Tyr Gly Leu Pro Lys Ala Gln Thr Thr Val Thr 
        115                 120                 125             


Cys Thr Glu Lys Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Arg 
    130                 135                 140                 


Thr Cys Ser Lys Ser Asp Ile Glu Ile Glu Asn Gly Phe Ile Ser Glu 
145                 150                 155                 160 


Ser Ser Ser Ile Tyr Ile Leu Asn Lys Glu Ile Gln Tyr Lys Cys Lys 
                165                 170                 175     


Pro Gly Tyr Ala Thr Ala Asp Gly Asn Ser Ser Asp Met Val Phe Cys 
            180                 185                 190         


Ile Ser Tyr 
        195 


<210>  2695
<211>  330
<212>  PRT
<213>  Homo Sapiens

<400>  2695

Met Leu Leu Leu Ile Asn Val Ile Leu Thr Leu Trp Val Ser Cys Ala 
1               5                   10                  15      


Asn Gly Gln Val Lys Pro Cys Asp Phe Pro Asp Ile Lys His Gly Gly 
            20                  25                  30          


Leu Phe His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly 
        35                  40                  45              


Lys Tyr Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly 
    50                  55                  60                  


Ser Tyr Trp Asp Tyr Ile His Cys Thr Gln Asn Gly Trp Ser Pro Ala 
65                  70                  75                  80  


Val Pro Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr 
                85                  90                  95      


Asn Gln Asn Tyr Gly Arg Lys Phe Val Gln Gly Asn Ser Thr Glu Val 
            100                 105                 110         


Ala Cys His Pro Gly Tyr Gly Leu Pro Lys Ala Gln Thr Thr Val Thr 
        115                 120                 125             


Cys Thr Glu Lys Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Arg 
    130                 135                 140                 


Thr Cys Ser Lys Ser Asp Ile Glu Ile Glu Asn Gly Phe Ile Ser Glu 
145                 150                 155                 160 


Ser Ser Ser Ile Tyr Ile Leu Asn Lys Glu Ile Gln Tyr Lys Cys Lys 
                165                 170                 175     


Pro Gly Tyr Ala Thr Ala Asp Gly Asn Ser Ser Gly Ser Ile Thr Cys 
            180                 185                 190         


Leu Gln Asn Gly Trp Ser Ala Gln Pro Ile Cys Ile Asn Ser Ser Glu 
        195                 200                 205             


Lys Cys Gly Pro Pro Pro Pro Ile Ser Asn Gly Asp Thr Thr Ser Phe 
    210                 215                 220                 


Leu Leu Lys Val Tyr Val Pro Gln Ser Arg Val Glu Tyr Gln Cys Gln 
225                 230                 235                 240 


Pro Tyr Tyr Glu Leu Gln Gly Ser Asn Tyr Val Thr Cys Ser Asn Gly 
                245                 250                 255     


Glu Trp Ser Glu Pro Pro Arg Cys Ile His Pro Cys Ile Ile Thr Glu 
            260                 265                 270         


Glu Asn Met Asn Lys Asn Asn Ile Lys Leu Lys Gly Arg Ser Asp Arg 
        275                 280                 285             


Lys Tyr Tyr Ala Lys Thr Gly Asp Thr Ile Glu Phe Met Cys Lys Leu 
    290                 295                 300                 


Gly Tyr Asn Ala Asn Thr Ser Ile Leu Ser Phe Gln Ala Val Cys Arg 
305                 310                 315                 320 


Glu Gly Ile Val Glu Tyr Pro Arg Cys Glu 
                325                 330 


<210>  2696
<211>  232
<212>  PRT
<213>  Homo Sapiens

<400>  2696

Met Leu Leu Leu Ile Asn Val Ile Leu Thr Leu Trp Val Ser Cys Ala 
1               5                   10                  15      


Asn Gly Gln Val Lys Pro Cys Asp Phe Pro Asp Ile Lys His Gly Gly 
            20                  25                  30          


Leu Phe His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly 
        35                  40                  45              


Lys Tyr Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly 
    50                  55                  60                  


Ser Tyr Trp Asp Tyr Ile His Cys Thr Gln Asn Gly Trp Ser Pro Ala 
65                  70                  75                  80  


Val Pro Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr 
                85                  90                  95      


Asn Gln Asn Tyr Gly Arg Lys Phe Val Gln Gly Asn Ser Thr Glu Val 
            100                 105                 110         


Ala Cys His Pro Gly Tyr Gly Leu Pro Lys Ala Gln Thr Thr Val Thr 
        115                 120                 125             


Cys Thr Glu Lys Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Arg 
    130                 135                 140                 


Thr Cys Ser Lys Ser Asp Ile Glu Ile Glu Asn Gly Phe Ile Ser Glu 
145                 150                 155                 160 


Ser Ser Ser Ile Tyr Ile Leu Asn Lys Glu Ile Gln Tyr Lys Cys Lys 
                165                 170                 175     


Pro Gly Tyr Ala Thr Ala Asp Gly Asn Ser Ser Gly Ser Ile Thr Cys 
            180                 185                 190         


Leu Gln Asn Gly Trp Ser Ala Gln Pro Ile Cys Ile Thr Ala Cys Ile 
        195                 200                 205             


Ala Phe Arg Ala His Ala Gln Lys Ser Cys Thr Cys Arg Gly Arg Asn 
    210                 215                 220                 


Glu Cys Leu Ile Leu Asn Phe Cys 
225                 230         


<210>  2697
<211>  232
<212>  PRT
<213>  Homo Sapiens

<400>  2697

Met Leu Leu Leu Ile Asn Val Ile Leu Thr Leu Trp Val Ser Cys Ala 
1               5                   10                  15      


Asn Gly Gln Val Lys Pro Cys Asp Phe Pro Asp Ile Lys His Gly Gly 
            20                  25                  30          


Leu Phe His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly 
        35                  40                  45              


Lys Tyr Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly 
    50                  55                  60                  


Ser Tyr Trp Asp Tyr Ile His Cys Thr Gln Asn Gly Trp Ser Pro Ala 
65                  70                  75                  80  


Val Pro Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr 
                85                  90                  95      


Asn Gln Asn Tyr Gly Arg Lys Phe Val Gln Gly Asn Ser Thr Glu Val 
            100                 105                 110         


Ala Cys His Pro Gly Tyr Gly Leu Pro Lys Ala Gln Thr Thr Val Thr 
        115                 120                 125             


Cys Thr Glu Lys Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Arg 
    130                 135                 140                 


Thr Cys Ser Lys Ser Asp Ile Glu Ile Glu Asn Gly Phe Ile Ser Glu 
145                 150                 155                 160 


Ser Ser Ser Ile Tyr Ile Leu Asn Lys Glu Ile Gln Tyr Lys Cys Lys 
                165                 170                 175     


Pro Gly Tyr Ala Thr Ala Asp Gly Asn Ser Ser Gly Ser Ile Thr Cys 
            180                 185                 190         


Leu Gln Asn Gly Trp Ser Ala Gln Pro Ile Cys Ile Thr Ala Cys Ile 
        195                 200                 205             


Ala Phe Arg Ala His Ala Gln Lys Ser Cys Thr Cys Arg Gly Arg Asn 
    210                 215                 220                 


Glu Cys Leu Ile Leu Asn Phe Cys 
225                 230         


<210>  2698
<211>  201
<212>  PRT
<213>  Homo Sapiens

<400>  2698

Met Glu Asn Gly Trp Ser Pro Pro Cys Arg Cys Ile Arg Val Arg Thr 
1               5                   10                  15      


Cys Ser Lys Ser Asp Ile Glu Ile Glu Asn Gly Phe Ile Ser Glu Ser 
            20                  25                  30          


Ser Ser Ile Tyr Ile Leu Asn Lys Glu Ile Gln Tyr Lys Cys Lys Pro 
        35                  40                  45              


Gly Tyr Ala Thr Ala Asp Gly Asn Ser Ser Gly Ser Ile Thr Cys Leu 
    50                  55                  60                  


Gln Asn Gly Trp Ser Ala Gln Pro Ile Cys Ile Asn Ser Ser Glu Lys 
65                  70                  75                  80  


Cys Gly Pro Pro Pro Pro Ile Ser Asn Gly Asp Thr Thr Ser Phe Leu 
                85                  90                  95      


Leu Lys Val Tyr Val Pro Gln Ser Arg Val Glu Tyr Gln Cys Gln Ser 
            100                 105                 110         


Tyr Tyr Glu Leu Gln Gly Ser Asn Tyr Val Thr Cys Ser Asn Gly Glu 
        115                 120                 125             


Trp Ser Glu Pro Pro Arg Cys Ile His Pro Cys Ile Ile Thr Glu Glu 
    130                 135                 140                 


Asn Met Asn Lys Asn Asn Ile Gln Leu Lys Gly Lys Ser Asp Ile Lys 
145                 150                 155                 160 


Tyr Tyr Ala Lys Thr Gly Asp Thr Ile Glu Phe Met Cys Lys Leu Gly 
                165                 170                 175     


Tyr Asn Ala Asn Thr Ser Val Leu Ser Phe Gln Ala Val Cys Arg Glu 
            180                 185                 190         


Gly Ile Val Glu Tyr Pro Arg Cys Glu 
        195                 200     


<210>  2699
<211>  331
<212>  PRT
<213>  Homo Sapiens

<400>  2699

Met Leu Leu Leu Ile Asn Val Ile Leu Thr Leu Trp Val Ser Cys Ala 
1               5                   10                  15      


Asn Gly Gln Glu Val Lys Pro Cys Asp Phe Pro Glu Ile Gln His Gly 
            20                  25                  30          


Gly Leu Tyr Tyr Lys Ser Leu Arg Arg Leu Tyr Phe Pro Ala Ala Ala 
        35                  40                  45              


Gly Gln Ser Tyr Ser Tyr Tyr Cys Asp Gln Asn Phe Val Thr Pro Ser 
    50                  55                  60                  


Gly Ser Tyr Trp Asp Tyr Ile His Cys Thr Gln Asp Gly Trp Leu Pro 
65                  70                  75                  80  


Thr Val Pro Cys Leu Arg Thr Cys Ser Lys Ser Asp Ile Glu Ile Glu 
                85                  90                  95      


Asn Gly Phe Ile Ser Glu Ser Ser Ser Ile Tyr Ile Leu Asn Lys Glu 
            100                 105                 110         


Ile Gln Tyr Lys Cys Lys Pro Gly Tyr Ala Thr Ala Asp Gly Asn Ser 
        115                 120                 125             


Ser Gly Ser Ile Thr Cys Leu Gln Asn Gly Trp Ser Ala Gln Pro Ile 
    130                 135                 140                 


Cys Ile Lys Phe Cys Asp Met Pro Val Phe Glu Asn Ser Arg Ala Lys 
145                 150                 155                 160 


Ser Asn Gly Met Arg Phe Lys Leu His Asp Thr Leu Asp Tyr Glu Cys 
                165                 170                 175     


Tyr Asp Gly Tyr Glu Ile Ser Tyr Gly Asn Thr Thr Gly Ser Ile Val 
            180                 185                 190         


Cys Gly Glu Asp Gly Trp Ser His Phe Pro Thr Cys Tyr Asn Ser Ser 
        195                 200                 205             


Glu Lys Cys Gly Pro Pro Pro Pro Ile Ser Asn Gly Asp Thr Thr Ser 
    210                 215                 220                 


Phe Leu Leu Lys Val Tyr Val Pro Gln Ser Arg Val Glu Tyr Gln Cys 
225                 230                 235                 240 


Gln Ser Tyr Tyr Glu Leu Gln Gly Ser Asn Tyr Val Thr Cys Ser Asn 
                245                 250                 255     


Gly Glu Trp Ser Glu Pro Pro Arg Cys Ile His Pro Cys Ile Ile Thr 
            260                 265                 270         


Glu Glu Asn Met Asn Lys Asn Asn Ile Gln Leu Lys Gly Lys Ser Asp 
        275                 280                 285             


Ile Lys Tyr Tyr Ala Lys Thr Gly Asp Thr Ile Glu Phe Met Cys Lys 
    290                 295                 300                 


Leu Gly Tyr Asn Ala Asn Thr Ser Val Leu Ser Phe Gln Ala Val Cys 
305                 310                 315                 320 


Arg Glu Gly Ile Val Glu Tyr Pro Arg Cys Glu 
                325                 330     


<210>  2700
<211>  331
<212>  PRT
<213>  Homo Sapiens

<400>  2700

Met Leu Leu Leu Ile Asn Val Ile Leu Thr Leu Trp Val Ser Cys Ala 
1               5                   10                  15      


Asn Gly Gln Glu Val Lys Pro Cys Asp Phe Pro Glu Ile Gln His Gly 
            20                  25                  30          


Gly Leu Tyr Tyr Lys Ser Leu Arg Arg Leu Tyr Phe Pro Ala Ala Ala 
        35                  40                  45              


Gly Gln Ser Tyr Ser Tyr Tyr Cys Asp Gln Asn Phe Val Thr Pro Ser 
    50                  55                  60                  


Gly Ser Tyr Trp Asp Tyr Ile His Cys Thr Gln Asp Gly Trp Ser Pro 
65                  70                  75                  80  


Thr Val Pro Cys Leu Arg Thr Cys Ser Lys Ser Asp Ile Glu Ile Glu 
                85                  90                  95      


Asn Gly Phe Ile Ser Glu Ser Ser Ser Ile Tyr Ile Leu Asn Lys Glu 
            100                 105                 110         


Ile Gln Tyr Lys Cys Lys Pro Gly Tyr Ala Thr Ala Asp Gly Asn Ser 
        115                 120                 125             


Ser Gly Ser Ile Thr Cys Leu Gln Asn Gly Trp Ser Ala Gln Pro Ile 
    130                 135                 140                 


Cys Ile Lys Phe Cys Asp Met Pro Val Phe Glu Asn Ser Arg Ala Lys 
145                 150                 155                 160 


Ser Asn Gly Met Arg Phe Lys Leu His Asp Thr Leu Asp Tyr Glu Cys 
                165                 170                 175     


Tyr Asp Gly Tyr Glu Ile Ser Tyr Gly Asn Thr Thr Gly Ser Ile Val 
            180                 185                 190         


Cys Gly Glu Asp Gly Trp Ser His Phe Pro Thr Cys Tyr Asn Ser Ser 
        195                 200                 205             


Glu Lys Cys Gly Pro Pro Pro Pro Ile Ser Asn Gly Asp Thr Thr Ser 
    210                 215                 220                 


Phe Leu Leu Lys Val Tyr Val Pro Gln Ser Arg Val Glu Tyr Gln Cys 
225                 230                 235                 240 


Gln Ser Tyr Tyr Glu Leu Gln Gly Ser Asn Tyr Val Thr Cys Ser Asn 
                245                 250                 255     


Gly Glu Trp Ser Glu Pro Pro Arg Cys Ile His Pro Cys Ile Ile Thr 
            260                 265                 270         


Glu Glu Asn Met Asn Lys Asn Asn Ile Gln Leu Lys Gly Lys Ser Asp 
        275                 280                 285             


Ile Lys Tyr Tyr Ala Lys Thr Gly Asp Thr Ile Glu Phe Met Cys Lys 
    290                 295                 300                 


Leu Gly Tyr Asn Ala Asn Thr Ser Val Leu Ser Phe Gln Ala Val Cys 
305                 310                 315                 320 


Arg Glu Gly Ile Val Glu Tyr Pro Arg Cys Glu 
                325                 330     


<210>  2701
<211>  577
<212>  PRT
<213>  Homo Sapiens

<400>  2701

Met Leu Leu Leu Ile Asn Val Ile Leu Thr Leu Trp Val Ser Cys Ala 
1               5                   10                  15      


Asn Gly Gln Val Lys Pro Cys Asp Phe Pro Glu Ile Gln His Gly Gly 
            20                  25                  30          


Leu Tyr Tyr Lys Ser Leu Arg Arg Leu Tyr Phe Pro Ala Ala Ala Gly 
        35                  40                  45              


Gln Ser Tyr Ser Tyr Tyr Cys Asp Gln Asn Phe Val Thr Pro Ser Gly 
    50                  55                  60                  


Ser Tyr Trp Asp Tyr Ile His Cys Thr Gln Asp Gly Trp Ser Pro Thr 
65                  70                  75                  80  


Val Pro Cys Leu Arg Thr Cys Ser Lys Ser Asp Val Glu Ile Glu Asn 
                85                  90                  95      


Gly Phe Ile Ser Glu Ser Ser Ser Ile Tyr Ile Leu Asn Glu Glu Thr 
            100                 105                 110         


Gln Tyr Asn Cys Lys Pro Gly Tyr Ala Thr Ala Glu Gly Asn Ser Ser 
        115                 120                 125             


Gly Ser Ile Thr Cys Leu Gln Asn Gly Trp Ser Thr Gln Pro Ile Cys 
    130                 135                 140                 


Ile Lys Phe Cys Asp Met Pro Val Phe Glu Asn Ser Arg Ala Lys Ser 
145                 150                 155                 160 


Asn Gly Met Trp Phe Lys Leu His Asp Thr Leu Asp Tyr Glu Cys Tyr 
                165                 170                 175     


Asp Gly Tyr Glu Ser Ser Tyr Gly Asn Thr Thr Asp Ser Ile Val Cys 
            180                 185                 190         


Gly Glu Asp Gly Trp Ser His Leu Pro Thr Cys Tyr Asn Ser Ser Glu 
        195                 200                 205             


Asn Cys Gly Pro Pro Pro Pro Ile Ser Asn Gly Asp Thr Thr Ser Phe 
    210                 215                 220                 


Pro Gln Lys Val Tyr Leu Pro Trp Ser Arg Val Glu Tyr Gln Cys Gln 
225                 230                 235                 240 


Ser Tyr Tyr Glu Leu Gln Gly Ser Lys Tyr Val Thr Cys Ser Asn Gly 
                245                 250                 255     


Asp Trp Ser Glu Pro Pro Arg Cys Ile Ser Met Lys Pro Cys Glu Phe 
            260                 265                 270         


Pro Glu Ile Gln His Gly His Leu Tyr Tyr Glu Asn Thr Arg Arg Pro 
        275                 280                 285             


Tyr Phe Pro Val Ala Thr Gly Gln Ser Tyr Ser Tyr Tyr Cys Asp Gln 
    290                 295                 300                 


Asn Phe Val Thr Pro Ser Gly Ser Tyr Trp Asp Tyr Ile His Cys Thr 
305                 310                 315                 320 


Gln Asp Gly Trp Leu Pro Thr Val Pro Cys Leu Arg Thr Cys Ser Lys 
                325                 330                 335     


Ser Asp Ile Glu Ile Glu Asn Gly Phe Ile Ser Glu Ser Ser Ser Ile 
            340                 345                 350         


Tyr Ile Leu Asn Lys Glu Ile Gln Tyr Lys Cys Lys Pro Gly Tyr Ala 
        355                 360                 365             


Thr Ala Asp Gly Asn Ser Ser Gly Ser Ile Thr Cys Leu Gln Asn Gly 
    370                 375                 380                 


Trp Ser Ala Gln Pro Ile Cys Ile Lys Phe Cys Asp Met Pro Val Phe 
385                 390                 395                 400 


Glu Asn Ser Arg Ala Lys Ser Asn Gly Met Arg Phe Lys Leu His Asp 
                405                 410                 415     


Thr Leu Asp Tyr Glu Cys Tyr Asp Gly Tyr Glu Ile Ser Tyr Gly Asn 
            420                 425                 430         


Thr Thr Gly Ser Ile Val Cys Gly Glu Asp Gly Trp Ser His Phe Pro 
        435                 440                 445             


Thr Cys Tyr Asn Ser Ser Glu Lys Cys Gly Pro Pro Pro Pro Ile Ser 
    450                 455                 460                 


Asn Gly Asp Thr Thr Ser Phe Leu Leu Lys Val Tyr Val Pro Gln Ser 
465                 470                 475                 480 


Arg Val Glu Tyr Gln Cys Gln Ser Tyr Tyr Glu Leu Gln Gly Ser Asn 
                485                 490                 495     


Tyr Val Thr Cys Ser Asn Gly Glu Trp Ser Glu Pro Pro Arg Cys Ile 
            500                 505                 510         


His Pro Cys Ile Ile Thr Glu Glu Asn Met Asn Lys Asn Asn Ile Gln 
        515                 520                 525             


Leu Lys Gly Lys Ser Asp Ile Lys Tyr Tyr Ala Lys Thr Gly Asp Thr 
    530                 535                 540                 


Ile Glu Phe Met Cys Lys Leu Gly Tyr Asn Ala Asn Thr Ser Val Leu 
545                 550                 555                 560 


Ser Phe Gln Ala Val Cys Arg Glu Gly Ile Val Glu Tyr Pro Arg Cys 
                565                 570                 575     


Glu 
    


<210>  2702
<211>  569
<212>  PRT
<213>  Homo Sapiens

<400>  2702

Met Leu Leu Leu Phe Ser Val Ile Leu Ile Ser Trp Val Ser Thr Val 
1               5                   10                  15      


Gly Gly Glu Gly Thr Leu Cys Asp Phe Pro Lys Ile His His Gly Phe 
            20                  25                  30          


Leu Tyr Asp Glu Glu Asp Tyr Asn Pro Phe Ser Gln Val Pro Thr Gly 
        35                  40                  45              


Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys 
    50                  55                  60                  


Ser Phe Trp Thr Arg Ile Thr Cys Thr Glu Glu Gly Trp Ser Pro Thr 
65                  70                  75                  80  


Pro Lys Cys Leu Arg Met Cys Ser Phe Pro Phe Val Lys Asn Gly His 
                85                  90                  95      


Ser Glu Ser Ser Gly Leu Ile His Leu Glu Gly Asp Thr Val Gln Ile 
            100                 105                 110         


Ile Cys Asn Thr Gly Tyr Ser Leu Gln Asn Asn Glu Lys Asn Ile Ser 
        115                 120                 125             


Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Ile Cys Ser Phe Thr Lys 
    130                 135                 140                 


Gly Glu Cys His Val Pro Ile Leu Glu Ala Asn Val Asp Ala Gln Pro 
145                 150                 155                 160 


Lys Lys Glu Ser Tyr Lys Val Gly Asp Val Leu Lys Phe Ser Cys Arg 
                165                 170                 175     


Lys Asn Leu Ile Arg Val Gly Ser Asp Ser Val Gln Cys Tyr Gln Phe 
            180                 185                 190         


Gly Trp Ser Pro Asn Phe Pro Thr Cys Lys Gly Gln Val Arg Ser Cys 
        195                 200                 205             


Gly Pro Pro Pro Gln Leu Ser Asn Gly Glu Val Lys Glu Ile Arg Lys 
    210                 215                 220                 


Glu Glu Tyr Gly His Asn Glu Val Val Glu Tyr Asp Cys Asn Pro Asn 
225                 230                 235                 240 


Phe Ile Ile Asn Gly Pro Lys Lys Ile Gln Cys Val Asp Gly Glu Trp 
                245                 250                 255     


Thr Thr Leu Pro Thr Cys Val Glu Gln Val Lys Thr Cys Gly Tyr Ile 
            260                 265                 270         


Pro Glu Leu Glu Tyr Gly Tyr Val Gln Pro Ser Val Pro Pro Tyr Gln 
        275                 280                 285             


His Gly Val Ser Val Glu Val Asn Cys Arg Asn Glu Tyr Ala Met Ile 
    290                 295                 300                 


Gly Asn Asn Met Ile Thr Cys Ile Asn Gly Ile Trp Thr Glu Leu Pro 
305                 310                 315                 320 


Met Cys Val Ala Thr His Gln Leu Lys Arg Cys Lys Ile Ala Gly Val 
                325                 330                 335     


Asn Ile Lys Thr Leu Leu Lys Leu Ser Gly Lys Glu Phe Asn His Asn 
            340                 345                 350         


Ser Arg Ile Arg Tyr Arg Cys Ser Asp Ile Phe Arg Tyr Arg His Ser 
        355                 360                 365             


Val Cys Ile Asn Gly Lys Trp Asn Pro Glu Val Asp Cys Thr Glu Lys 
    370                 375                 380                 


Arg Glu Gln Phe Cys Pro Pro Pro Pro Gln Ile Pro Asn Ala Gln Asn 
385                 390                 395                 400 


Met Thr Thr Thr Val Asn Tyr Gln Asp Gly Glu Lys Val Ala Val Leu 
                405                 410                 415     


Cys Lys Glu Asn Tyr Leu Leu Pro Glu Ala Lys Glu Ile Val Cys Lys 
            420                 425                 430         


Asp Gly Arg Trp Gln Ser Leu Pro Arg Cys Val Glu Ser Thr Ala Tyr 
        435                 440                 445             


Cys Gly Pro Pro Pro Ser Ile Asn Asn Gly Asp Thr Thr Ser Phe Pro 
    450                 455                 460                 


Leu Ser Val Tyr Pro Pro Gly Ser Thr Val Thr Tyr Arg Cys Gln Ser 
465                 470                 475                 480 


Phe Tyr Lys Leu Gln Gly Ser Val Thr Val Thr Cys Arg Asn Lys Gln 
                485                 490                 495     


Trp Ser Glu Pro Pro Arg Cys Leu Asp Pro Cys Val Val Ser Glu Glu 
            500                 505                 510         


Asn Met Asn Lys Asn Asn Ile Gln Leu Lys Trp Arg Asn Asp Gly Lys 
        515                 520                 525             


Leu Tyr Ala Lys Thr Gly Asp Ala Val Glu Phe Gln Cys Lys Phe Pro 
    530                 535                 540                 


His Lys Ala Met Ile Ser Ser Pro Pro Phe Arg Ala Ile Cys Gln Glu 
545                 550                 555                 560 


Gly Lys Phe Glu Tyr Pro Ile Cys Glu 
                565                 


<210>  2703
<211>  161
<212>  PRT
<213>  Homo Sapiens

<400>  2703

Met Lys Leu Leu His Val Phe Leu Leu Phe Leu Cys Phe His Leu Arg 
1               5                   10                  15      


Phe Cys Lys Val Thr Tyr Thr Ser Gln Glu Asp Leu Val Glu Lys Lys 
            20                  25                  30          


Cys Leu Ala Lys Lys Tyr Thr His Leu Ser Cys Asp Lys Val Phe Cys 
        35                  40                  45              


Gln Pro Trp Gln Arg Cys Ile Glu Gly Thr Cys Val Cys Lys Leu Pro 
    50                  55                  60                  


Tyr Gln Cys Pro Lys Asn Gly Thr Ala Val Cys Ala Thr Asn Arg Arg 
65                  70                  75                  80  


Ser Phe Pro Thr Tyr Cys Gln Gln Lys Ser Leu Glu Cys Leu His Pro 
                85                  90                  95      


Gly Thr Lys Phe Leu Asn Asn Gly Thr Cys Thr Ala Glu Gly Lys Phe 
            100                 105                 110         


Ser Val Ser Leu Lys His Gly Asn Thr Asp Ser Glu Gly Ile Val Glu 
        115                 120                 125             


Val Lys Leu Val Asp Gln Asp Lys Thr Met Phe Ile Cys Lys Ser Ser 
    130                 135                 140                 


Trp Ser Met Arg Glu Ala Asn Val Ala Cys Leu Asp Leu Gly Phe Gln 
145                 150                 155                 160 


Gln 
    


<210>  2704
<211>  591
<212>  PRT
<213>  Homo Sapiens

<400>  2704

Met Lys Leu Leu His Val Phe Leu Leu Phe Leu Cys Phe His Leu Arg 
1               5                   10                  15      


Phe Cys Lys Val Thr Tyr Thr Ser Gln Glu Asp Leu Val Glu Lys Lys 
            20                  25                  30          


Cys Leu Ala Lys Lys Tyr Thr His Leu Ser Cys Asp Lys Val Phe Cys 
        35                  40                  45              


Gln Pro Trp Gln Arg Cys Ile Glu Gly Thr Cys Val Cys Lys Leu Pro 
    50                  55                  60                  


Tyr Gln Cys Pro Lys Asn Gly Thr Ala Val Cys Ala Thr Asn Arg Arg 
65                  70                  75                  80  


Ser Phe Pro Thr Tyr Cys Gln Gln Lys Ser Leu Glu Cys Leu His Pro 
                85                  90                  95      


Gly Thr Lys Phe Leu Asn Asn Gly Thr Cys Thr Ala Glu Gly Lys Phe 
            100                 105                 110         


Ser Val Ser Leu Lys His Gly Asn Thr Asp Ser Glu Gly Ile Val Glu 
        115                 120                 125             


Val Lys Leu Val Asp Gln Asp Lys Thr Met Phe Ile Cys Lys Ser Ser 
    130                 135                 140                 


Trp Ser Met Arg Glu Ala Asn Val Ala Cys Leu Asp Leu Gly Phe Gln 
145                 150                 155                 160 


Gln Gly Ala Asp Thr Gln Arg Arg Phe Lys Leu Ser Asp Leu Ser Ile 
                165                 170                 175     


Asn Ser Thr Glu Cys Leu His Val His Cys Arg Gly Leu Glu Thr Ser 
            180                 185                 190         


Leu Ala Glu Cys Thr Phe Thr Lys Arg Arg Thr Met Gly Tyr Gln Asp 
        195                 200                 205             


Phe Ala Asp Val Val Cys Tyr Thr Gln Lys Ala Asp Ser Pro Met Asp 
    210                 215                 220                 


Asp Phe Phe Gln Cys Val Asn Gly Lys Tyr Ile Ser Gln Met Lys Ala 
225                 230                 235                 240 


Cys Asp Gly Ile Asn Asp Cys Gly Asp Gln Ser Asp Glu Leu Cys Cys 
                245                 250                 255     


Lys Ala Cys Gln Gly Lys Gly Phe His Cys Lys Ser Gly Val Cys Ile 
            260                 265                 270         


Pro Ser Gln Tyr Gln Cys Asn Gly Glu Val Asp Cys Ile Thr Gly Glu 
        275                 280                 285             


Asp Glu Val Gly Cys Ala Ala Ala Arg His Pro Thr Ile Gln Gly Phe 
    290                 295                 300                 


Ala Ser Val Thr Gln Glu Glu Thr Glu Ile Leu Thr Ala Asp Met Asp 
305                 310                 315                 320 


Ala Glu Arg Arg Arg Ile Lys Ser Leu Leu Pro Lys Leu Ser Cys Gly 
                325                 330                 335     


Val Lys Asn Arg Met His Ile Arg Arg Lys Arg Ile Val Gly Gly Lys 
            340                 345                 350         


Arg Ala Gln Leu Gly Asp Leu Pro Trp Gln Val Ala Ile Lys Asp Ala 
        355                 360                 365             


Ser Gly Ile Thr Cys Gly Gly Ile Tyr Ile Gly Gly Cys Trp Ile Leu 
    370                 375                 380                 


Thr Ala Ala His Cys Leu Arg Ala Ser Lys Thr His Arg Tyr Gln Ile 
385                 390                 395                 400 


Trp Thr Thr Val Val Asp Trp Ile His Pro Asp Leu Lys Arg Ile Val 
                405                 410                 415     


Ile Glu Tyr Val Asp Arg Ile Ile Phe His Glu Asn Tyr Asn Ala Gly 
            420                 425                 430         


Thr Tyr Gln Asn Asp Ile Ala Leu Ile Glu Met Lys Lys Asp Gly Asn 
        435                 440                 445             


Lys Lys Asp Cys Glu Leu Pro Arg Ser Ile Pro Ala Cys Val Pro Trp 
    450                 455                 460                 


Ser Pro Tyr Leu Phe Gln Pro Asn Asp Thr Cys Ile Val Ser Gly Trp 
465                 470                 475                 480 


Gly Arg Glu Lys Asp Asn Glu Arg Val Phe Ser Leu Gln Trp Gly Glu 
                485                 490                 495     


Val Lys Leu Ile Ser Asn Cys Ser Lys Phe Tyr Gly Asn Arg Phe Tyr 
            500                 505                 510         


Glu Lys Glu Met Glu Cys Ala Gly Thr Tyr Asp Gly Ser Ile Asp Ala 
        515                 520                 525             


Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Cys Met Asp Ala Asn Asn 
    530                 535                 540                 


Val Thr Tyr Val Trp Gly Val Val Ser Trp Gly Glu Asn Cys Gly Lys 
545                 550                 555                 560 


Pro Glu Phe Pro Gly Val Tyr Thr Lys Val Ala Asn Tyr Phe Asp Trp 
                565                 570                 575     


Ile Ser Tyr His Val Gly Arg Pro Phe Ile Ser Gln Tyr Asn Val 
            580                 585                 590     


<210>  2705
<211>  583
<212>  PRT
<213>  Homo Sapiens

<400>  2705

Met Lys Leu Leu His Val Phe Leu Leu Phe Leu Cys Phe His Leu Arg 
1               5                   10                  15      


Phe Cys Lys Val Thr Tyr Thr Ser Gln Glu Asp Leu Val Glu Lys Lys 
            20                  25                  30          


Cys Leu Ala Lys Lys Tyr Thr His Leu Ser Cys Asp Lys Val Phe Cys 
        35                  40                  45              


Gln Pro Trp Gln Arg Cys Ile Glu Gly Thr Cys Val Cys Lys Leu Pro 
    50                  55                  60                  


Tyr Gln Cys Pro Lys Asn Gly Thr Ala Val Cys Ala Thr Asn Arg Arg 
65                  70                  75                  80  


Ser Phe Pro Thr Tyr Cys Gln Gln Lys Ser Leu Glu Cys Leu His Pro 
                85                  90                  95      


Gly Thr Lys Phe Leu Asn Asn Gly Thr Cys Thr Ala Glu Gly Lys Phe 
            100                 105                 110         


Ser Val Ser Leu Lys His Gly Asn Thr Asp Ser Glu Gly Ile Val Glu 
        115                 120                 125             


Val Lys Leu Val Asp Gln Asp Lys Thr Met Phe Ile Cys Lys Ser Ser 
    130                 135                 140                 


Trp Ser Met Arg Glu Ala Asn Val Ala Cys Leu Asp Leu Gly Phe Gln 
145                 150                 155                 160 


Gln Gly Ala Asp Thr Gln Arg Arg Phe Lys Leu Ser Asp Leu Ser Ile 
                165                 170                 175     


Asn Ser Thr Glu Cys Leu His Val His Cys Arg Gly Leu Glu Thr Ser 
            180                 185                 190         


Leu Ala Glu Cys Thr Phe Thr Lys Arg Arg Thr Met Gly Tyr Gln Asp 
        195                 200                 205             


Phe Ala Asp Val Val Cys Tyr Thr Gln Lys Ala Asp Ser Pro Met Asp 
    210                 215                 220                 


Asp Phe Phe Gln Cys Val Asn Gly Lys Tyr Ile Ser Gln Met Lys Ala 
225                 230                 235                 240 


Cys Asp Gly Ile Asn Asp Cys Gly Asp Gln Ser Asp Glu Leu Cys Cys 
                245                 250                 255     


Lys Ala Cys Gln Gly Lys Gly Phe His Cys Lys Ser Gly Val Cys Ile 
            260                 265                 270         


Pro Ser Gln Tyr Gln Cys Asn Gly Glu Val Asp Cys Ile Thr Gly Glu 
        275                 280                 285             


Asp Glu Val Gly Cys Ala Gly Phe Ala Ser Val Thr Gln Glu Glu Thr 
    290                 295                 300                 


Glu Ile Leu Thr Ala Asp Met Asp Ala Glu Arg Arg Arg Ile Lys Ser 
305                 310                 315                 320 


Leu Leu Pro Lys Leu Ser Cys Gly Val Lys Asn Arg Met His Ile Arg 
                325                 330                 335     


Arg Lys Arg Ile Val Gly Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro 
            340                 345                 350         


Trp Gln Val Ala Ile Lys Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile 
        355                 360                 365             


Tyr Ile Gly Gly Cys Trp Ile Leu Thr Ala Ala His Cys Leu Arg Ala 
    370                 375                 380                 


Ser Lys Thr His Arg Tyr Gln Ile Trp Thr Thr Val Val Asp Trp Ile 
385                 390                 395                 400 


His Pro Asp Leu Lys Arg Ile Val Ile Glu Tyr Val Asp Arg Ile Ile 
                405                 410                 415     


Phe His Glu Asn Tyr Asn Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu 
            420                 425                 430         


Ile Glu Met Lys Lys Asp Gly Asn Lys Lys Asp Cys Glu Leu Pro Arg 
        435                 440                 445             


Ser Ile Pro Ala Cys Val Pro Trp Ser Pro Tyr Leu Phe Gln Pro Asn 
    450                 455                 460                 


Asp Thr Cys Ile Val Ser Gly Trp Gly Arg Glu Lys Asp Asn Glu Arg 
465                 470                 475                 480 


Val Phe Ser Leu Gln Trp Gly Glu Val Lys Leu Ile Ser Asn Cys Ser 
                485                 490                 495     


Lys Phe Tyr Gly Asn Arg Phe Tyr Glu Lys Glu Met Glu Cys Ala Gly 
            500                 505                 510         


Thr Tyr Asp Gly Ser Ile Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro 
        515                 520                 525             


Leu Val Cys Met Asp Ala Asn Asn Val Thr Tyr Val Trp Gly Val Val 
    530                 535                 540                 


Ser Trp Gly Glu Asn Cys Gly Lys Pro Glu Phe Pro Gly Val Tyr Thr 
545                 550                 555                 560 


Lys Val Ala Asn Tyr Phe Asp Trp Ile Ser Tyr His Val Gly Arg Pro 
                565                 570                 575     


Phe Ile Ser Gln Tyr Asn Val 
            580             


<210>  2706
<211>  576
<212>  PRT
<213>  Homo Sapiens

<400>  2706

Met Lys Leu Leu His Val Phe Leu Leu Phe Leu Cys Phe His Leu Arg 
1               5                   10                  15      


Phe Cys Lys Val Thr Tyr Thr Ser Gln Glu Asp Leu Val Glu Lys Lys 
            20                  25                  30          


Cys Leu Ala Lys Lys Tyr Thr His Leu Ser Cys Asp Lys Val Phe Cys 
        35                  40                  45              


Gln Pro Trp Gln Arg Cys Ile Glu Gly Thr Cys Val Cys Lys Leu Pro 
    50                  55                  60                  


Tyr Gln Cys Pro Lys Asn Gly Thr Ala Val Cys Ala Thr Asn Arg Arg 
65                  70                  75                  80  


Ser Phe Pro Thr Tyr Cys Gln Gln Lys Ser Leu Glu Cys Leu His Pro 
                85                  90                  95      


Gly Thr Lys Phe Leu Asn Asn Gly Thr Cys Thr Ala Glu Gly Lys Phe 
            100                 105                 110         


Ser Val Ser Leu Lys His Gly Asn Thr Asp Ser Glu Gly Ile Val Glu 
        115                 120                 125             


Val Lys Leu Val Asp Gln Asp Lys Thr Met Phe Ile Cys Lys Ser Ser 
    130                 135                 140                 


Trp Ser Met Arg Glu Ala Asn Val Ala Cys Leu Asp Leu Gly Phe Gln 
145                 150                 155                 160 


Gln Gly Ala Asp Thr Gln Arg Arg Phe Lys Leu Ser Asp Leu Ser Ile 
                165                 170                 175     


Asn Ser Thr Glu Cys Leu His Val His Cys Arg Gly Leu Glu Thr Ser 
            180                 185                 190         


Leu Ala Glu Cys Thr Phe Thr Lys Arg Arg Thr Met Gly Tyr Gln Asp 
        195                 200                 205             


Phe Ala Asp Val Val Cys Tyr Thr Gln Lys Ala Asp Ser Pro Met Asp 
    210                 215                 220                 


Asp Phe Phe Gln Cys Val Asn Gly Lys Tyr Ile Ser Gln Met Lys Ala 
225                 230                 235                 240 


Cys Asp Gly Ile Asn Asp Cys Gly Asp Gln Ser Asp Glu Leu Cys Cys 
                245                 250                 255     


Lys Ala Cys Gln Gly Lys Gly Phe His Cys Lys Ser Gly Val Cys Ile 
            260                 265                 270         


Pro Ser Gln Tyr Gln Cys Asn Gly Glu Val Asp Cys Ile Thr Gly Glu 
        275                 280                 285             


Asp Glu Val Gly Cys Ala Glu Glu Thr Glu Ile Leu Thr Ala Asp Met 
    290                 295                 300                 


Asp Ala Glu Arg Arg Arg Ile Lys Ser Leu Leu Pro Lys Leu Ser Cys 
305                 310                 315                 320 


Gly Val Lys Asn Arg Met His Ile Arg Arg Lys Arg Ile Val Gly Gly 
                325                 330                 335     


Lys Arg Ala Gln Leu Gly Asp Leu Pro Trp Gln Val Ala Ile Lys Asp 
            340                 345                 350         


Ala Ser Gly Ile Thr Cys Gly Gly Ile Tyr Ile Gly Gly Cys Trp Ile 
        355                 360                 365             


Leu Thr Ala Ala His Cys Leu Arg Ala Ser Lys Thr His Arg Tyr Gln 
    370                 375                 380                 


Ile Trp Thr Thr Val Val Asp Trp Ile His Pro Asp Leu Lys Arg Ile 
385                 390                 395                 400 


Val Ile Glu Tyr Val Asp Arg Ile Ile Phe His Glu Asn Tyr Asn Ala 
                405                 410                 415     


Gly Thr Tyr Gln Asn Asp Ile Ala Leu Ile Glu Met Lys Lys Asp Gly 
            420                 425                 430         


Asn Lys Lys Asp Cys Glu Leu Pro Arg Ser Ile Pro Ala Cys Val Pro 
        435                 440                 445             


Trp Ser Pro Tyr Leu Phe Gln Pro Asn Asp Thr Cys Ile Val Ser Gly 
    450                 455                 460                 


Trp Gly Arg Glu Lys Asp Asn Glu Arg Val Phe Ser Leu Gln Trp Gly 
465                 470                 475                 480 


Glu Val Lys Leu Ile Ser Asn Cys Ser Lys Phe Tyr Gly Asn Arg Phe 
                485                 490                 495     


Tyr Glu Lys Glu Met Glu Cys Ala Gly Thr Tyr Asp Gly Ser Ile Asp 
            500                 505                 510         


Ala Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Cys Met Asp Ala Asn 
        515                 520                 525             


Asn Val Thr Tyr Val Trp Gly Val Val Ser Trp Gly Glu Asn Cys Gly 
    530                 535                 540                 


Lys Pro Glu Phe Pro Gly Val Tyr Thr Lys Val Ala Asn Tyr Phe Asp 
545                 550                 555                 560 


Trp Ile Ser Tyr His Val Gly Arg Pro Phe Ile Ser Gln Tyr Asn Val 
                565                 570                 575     


<210>  2707
<211>  378
<212>  PRT
<213>  Homo Sapiens

<400>  2707

Met Lys Leu Leu His Val Phe Leu Leu Phe Leu Cys Phe His Leu Arg 
1               5                   10                  15      


Phe Cys Lys Val Thr Tyr Thr Ser Gln Glu Asp Leu Val Glu Lys Lys 
            20                  25                  30          


Cys Leu Ala Lys Lys Tyr Thr His Leu Ser Cys Asp Lys Val Phe Cys 
        35                  40                  45              


Gln Pro Trp Gln Arg Cys Ile Glu Gly Thr Cys Val Cys Lys Leu Pro 
    50                  55                  60                  


Tyr Gln Cys Pro Lys Asn Gly Thr Ala Val Cys Ala Thr Asn Arg Arg 
65                  70                  75                  80  


Ser Phe Pro Thr Tyr Cys Gln Gln Lys Ser Leu Glu Cys Leu His Pro 
                85                  90                  95      


Gly Thr Lys Phe Leu Asn Asn Gly Thr Cys Thr Ala Glu Gly Lys Phe 
            100                 105                 110         


Ser Val Ser Leu Lys His Gly Asn Thr Asp Ser Glu Gly Ile Val Glu 
        115                 120                 125             


Val Lys Leu Val Asp Gln Asp Lys Thr Met Phe Ile Cys Lys Ser Ser 
    130                 135                 140                 


Trp Ser Met Arg Glu Ala Asn Val Ala Cys Leu Asp Leu Gly Phe Gln 
145                 150                 155                 160 


Gln Gly Ala Asp Thr Gln Arg Arg Phe Lys Leu Ser Asp Leu Ser Ile 
                165                 170                 175     


Asn Ser Thr Glu Cys Leu His Val His Cys Arg Gly Leu Glu Thr Ser 
            180                 185                 190         


Leu Ala Glu Cys Thr Phe Thr Lys Arg Arg Thr Met Gly Tyr Gln Asp 
        195                 200                 205             


Phe Ala Asp Val Val Cys Tyr Thr Gln Lys Ala Asp Ser Pro Met Asp 
    210                 215                 220                 


Asp Phe Phe Gln Cys Val Asn Gly Lys Tyr Ile Ser Gln Met Lys Ala 
225                 230                 235                 240 


Cys Asp Gly Ile Asn Asp Cys Gly Asp Gln Ser Asp Glu Leu Cys Cys 
                245                 250                 255     


Lys Ala Cys Gln Gly Lys Gly Phe His Cys Lys Ser Gly Val Cys Ile 
            260                 265                 270         


Pro Ser Gln Tyr Gln Cys Asn Gly Glu Val Asp Cys Ile Thr Gly Glu 
        275                 280                 285             


Asp Glu Val Gly Cys Ala Gly Phe Ala Ser Val Thr Gln Glu Glu Thr 
    290                 295                 300                 


Glu Ile Leu Thr Ala Asp Met Asp Ala Glu Arg Arg Arg Ile Lys Ser 
305                 310                 315                 320 


Leu Leu Pro Lys Leu Ser Cys Gly Val Lys Asn Arg Met His Ile Arg 
                325                 330                 335     


Arg Lys Arg Ile Val Gly Gly Lys Arg Ala Gln Leu Gly Gly Lys Met 
            340                 345                 350         


Lys Gln Ile Ser Leu Asp Ile Phe Lys Gly Leu His Arg Val Tyr Ala 
        355                 360                 365             


Ile Leu Glu Phe Cys Cys Ile Ile Leu Lys 
    370                 375             


<210>  2708
<211>  167
<212>  PRT
<213>  Homo Sapiens

<400>  2708

Met Gly Gly Trp Ser Gly Trp Gly Pro Trp Glu Pro Cys Ser Val Thr 
1               5                   10                  15      


Cys Ser Lys Gly Thr Arg Thr Arg Arg Arg Ala Cys Asn His Pro Ala 
            20                  25                  30          


Pro Lys Cys Gly Gly His Cys Pro Gly Gln Ala Gln Glu Ser Glu Ala 
        35                  40                  45              


Cys Asp Thr Gln Gln Val Cys Pro Thr His Gly Ala Trp Ala Thr Trp 
    50                  55                  60                  


Gly Pro Trp Thr Pro Cys Ser Ala Ser Cys His Gly Gly Pro His Glu 
65                  70                  75                  80  


Pro Lys Glu Thr Arg Ser Arg Lys Cys Ser Ala Pro Glu Pro Ser Gln 
                85                  90                  95      


Lys Pro Pro Gly Lys Pro Cys Pro Gly Leu Ala Tyr Glu Gln Arg Arg 
            100                 105                 110         


Cys Thr Gly Leu Pro Pro Cys Pro Val Ala Gly Gly Trp Gly Pro Trp 
        115                 120                 125             


Gly Pro Val Ser Pro Cys Pro Val Thr Cys Gly Leu Gly Gln Thr Met 
    130                 135                 140                 


Glu Gln Arg Thr Cys Asn His Pro Val Pro Gln His Gly Gly Pro Phe 
145                 150                 155                 160 


Cys Ala Gly Asp Ala Thr Arg 
                165         


<210>  2709
<211>  469
<212>  PRT
<213>  Homo Sapiens

<400>  2709

Met Ile Thr Glu Gly Ala Gln Ala Pro Arg Leu Leu Leu Pro Pro Leu 
1               5                   10                  15      


Leu Leu Leu Leu Thr Leu Pro Ala Thr Gly Ser Asp Pro Val Leu Cys 
            20                  25                  30          


Phe Thr Gln Tyr Glu Glu Ser Ser Gly Lys Cys Lys Gly Leu Leu Gly 
        35                  40                  45              


Gly Gly Val Ser Val Glu Asp Cys Cys Leu Asn Thr Ala Phe Ala Tyr 
    50                  55                  60                  


Gln Lys Arg Ser Gly Gly Leu Cys Gln Pro Cys Arg Ser Pro Arg Trp 
65                  70                  75                  80  


Ser Leu Trp Ser Thr Trp Ala Pro Cys Ser Val Thr Cys Ser Glu Gly 
                85                  90                  95      


Ser Gln Leu Arg Tyr Arg Arg Cys Val Gly Trp Asn Gly Gln Cys Ser 
            100                 105                 110         


Gly Lys Val Ala Pro Gly Thr Leu Glu Trp Gln Leu Gln Ala Cys Glu 
        115                 120                 125             


Asp Gln Gln Cys Cys Pro Glu Met Gly Gly Trp Ser Gly Trp Gly Pro 
    130                 135                 140                 


Trp Glu Pro Cys Ser Val Thr Cys Ser Lys Gly Thr Arg Thr Arg Arg 
145                 150                 155                 160 


Arg Ala Cys Asn His Pro Ala Pro Lys Cys Gly Gly His Cys Pro Gly 
                165                 170                 175     


Gln Ala Gln Glu Ser Glu Ala Cys Asp Thr Gln Gln Val Cys Pro Thr 
            180                 185                 190         


His Gly Ala Trp Ala Thr Trp Gly Pro Trp Thr Pro Cys Ser Ala Ser 
        195                 200                 205             


Cys His Gly Gly Pro His Glu Pro Lys Glu Thr Arg Ser Arg Lys Cys 
    210                 215                 220                 


Ser Ala Pro Glu Pro Ser Gln Lys Pro Pro Gly Lys Pro Cys Pro Gly 
225                 230                 235                 240 


Leu Ala Tyr Glu Gln Arg Arg Cys Thr Gly Leu Pro Pro Cys Pro Val 
                245                 250                 255     


Ala Gly Gly Trp Gly Pro Trp Gly Pro Val Ser Pro Cys Pro Val Thr 
            260                 265                 270         


Cys Gly Leu Gly Gln Thr Met Glu Gln Arg Thr Cys Asn His Pro Val 
        275                 280                 285             


Pro Gln His Gly Gly Pro Phe Cys Ala Gly Asp Ala Thr Arg Thr His 
    290                 295                 300                 


Ile Cys Asn Thr Ala Val Pro Cys Pro Val Asp Gly Glu Trp Asp Ser 
305                 310                 315                 320 


Trp Gly Glu Trp Ser Pro Cys Ile Arg Arg Asn Met Lys Ser Ile Ser 
                325                 330                 335     


Cys Gln Glu Ile Pro Gly Gln Gln Ser Arg Gly Arg Thr Cys Arg Gly 
            340                 345                 350         


Arg Lys Phe Asp Gly His Arg Cys Ala Gly Gln Gln Gln Asp Ile Arg 
        355                 360                 365             


His Cys Tyr Ser Ile Gln His Cys Pro Leu Lys Gly Ser Trp Ser Glu 
    370                 375                 380                 


Trp Ser Thr Trp Gly Leu Cys Met Pro Pro Cys Gly Pro Asn Pro Thr 
385                 390                 395                 400 


Arg Ala Arg Gln Arg Leu Cys Thr Pro Leu Leu Pro Lys Tyr Pro Pro 
                405                 410                 415     


Thr Val Ser Met Val Glu Gly Gln Gly Glu Lys Asn Val Thr Phe Trp 
            420                 425                 430         


Gly Arg Pro Leu Pro Arg Cys Glu Glu Leu Gln Gly Gln Lys Leu Val 
        435                 440                 445             


Val Glu Glu Lys Arg Pro Cys Leu His Val Pro Ala Cys Lys Asp Pro 
    450                 455                 460                 


Glu Glu Glu Glu Leu 
465                 


<210>  2710
<211>  415
<212>  PRT
<213>  Homo Sapiens

<400>  2710

Met Ile Thr Glu Gly Ala Gln Ala Pro Arg Leu Leu Leu Pro Pro Leu 
1               5                   10                  15      


Leu Leu Leu Leu Thr Leu Pro Ala Thr Gly Ser Asp Pro Val Leu Cys 
            20                  25                  30          


Phe Thr Gln Tyr Glu Glu Ser Ser Gly Lys Cys Lys Gly Leu Leu Gly 
        35                  40                  45              


Gly Gly Val Ser Val Glu Asp Cys Cys Leu Asn Thr Ala Phe Ala Tyr 
    50                  55                  60                  


Gln Lys Arg Ser Gly Gly Leu Cys Gln Pro Cys Arg Ser Pro Arg Trp 
65                  70                  75                  80  


Ser Leu Trp Ser Thr Trp Ala Pro Cys Ser Val Thr Cys Ser Glu Gly 
                85                  90                  95      


Ser Gln Leu Arg Tyr Arg Arg Cys Val Gly Trp Asn Gly Gln Cys Ser 
            100                 105                 110         


Gly Lys Val Ala Pro Gly Thr Leu Glu Trp Gln Leu Gln Ala Cys Glu 
        115                 120                 125             


Asp Gln Gln Cys Cys Pro Glu Met Gly Gly Trp Ser Gly Trp Gly Pro 
    130                 135                 140                 


Trp Glu Pro Cys Ser Val Thr Cys Ser Lys Gly Thr Arg Thr Arg Arg 
145                 150                 155                 160 


Arg Ala Cys Asn His Pro Ala Pro Lys Cys Gly Gly His Cys Pro Gly 
                165                 170                 175     


Gln Ala Gln Glu Ser Glu Ala Cys Asp Thr Gln Gln Val Cys Pro Thr 
            180                 185                 190         


His Gly Ala Trp Ala Thr Trp Gly Pro Trp Thr Pro Cys Ser Ala Ser 
        195                 200                 205             


Cys His Gly Gly Pro His Glu Pro Lys Glu Thr Arg Ser Arg Lys Cys 
    210                 215                 220                 


Ser Ala Pro Glu Pro Ser Gln Lys Pro Pro Gly Lys Pro Cys Pro Gly 
225                 230                 235                 240 


Leu Ala Tyr Glu Gln Arg Arg Cys Thr Gly Leu Pro Pro Cys Pro Val 
                245                 250                 255     


Ala Gly Gly Trp Gly Pro Trp Gly Pro Val Ser Pro Cys Pro Val Thr 
            260                 265                 270         


Cys Gly Leu Gly Gln Thr Met Glu Gln Arg Thr Cys Asn His Pro Val 
        275                 280                 285             


Pro Gln His Gly Gly Pro Phe Cys Ala Gly Asp Ala Thr Arg Thr His 
    290                 295                 300                 


Ile Cys Asn Thr Ala Val Pro Cys Pro Val Asp Gly Glu Trp Asp Ser 
305                 310                 315                 320 


Trp Gly Glu Trp Ser Pro Cys Ile Arg Arg Asn Met Lys Ser Ile Ser 
                325                 330                 335     


Cys Gln Glu Ile Pro Gly Gln Gln Ser Arg Gly Arg Thr Cys Arg Gly 
            340                 345                 350         


Arg Lys Phe Asp Gly His Arg Cys Ala Gly Gln Gln Gln Asp Ile Arg 
        355                 360                 365             


His Cys Tyr Ser Ile Gln His Cys Pro Leu Lys Gly Ser Trp Ser Glu 
    370                 375                 380                 


Trp Ser Thr Trp Gly Leu Cys Met Pro Pro Cys Gly Pro Asn Pro Thr 
385                 390                 395                 400 


Arg Ala Arg Gln Arg Leu Cys Thr Pro Leu Leu Pro Lys Tyr Pro 
                405                 410                 415 


<210>  2711
<211>  469
<212>  PRT
<213>  Homo Sapiens

<400>  2711

Met Ile Thr Glu Gly Ala Gln Ala Pro Arg Leu Leu Leu Pro Pro Leu 
1               5                   10                  15      


Leu Leu Leu Leu Thr Leu Pro Ala Thr Gly Ser Asp Pro Val Leu Cys 
            20                  25                  30          


Phe Thr Gln Tyr Glu Glu Ser Ser Gly Lys Cys Lys Gly Leu Leu Gly 
        35                  40                  45              


Gly Gly Val Ser Val Glu Asp Cys Cys Leu Asn Thr Ala Phe Ala Tyr 
    50                  55                  60                  


Gln Lys Arg Ser Gly Gly Leu Cys Gln Pro Cys Arg Ser Pro Arg Trp 
65                  70                  75                  80  


Ser Leu Trp Ser Thr Trp Ala Pro Cys Ser Val Thr Cys Ser Glu Gly 
                85                  90                  95      


Ser Gln Leu Arg Tyr Arg Arg Cys Val Gly Trp Asn Gly Gln Cys Ser 
            100                 105                 110         


Gly Lys Val Ala Pro Gly Thr Leu Glu Trp Gln Leu Gln Ala Cys Glu 
        115                 120                 125             


Asp Gln Gln Cys Cys Pro Glu Met Gly Gly Trp Ser Gly Trp Gly Pro 
    130                 135                 140                 


Trp Glu Pro Cys Ser Val Thr Cys Ser Lys Gly Thr Arg Thr Arg Arg 
145                 150                 155                 160 


Arg Ala Cys Asn His Pro Ala Pro Lys Cys Gly Gly His Cys Pro Gly 
                165                 170                 175     


Gln Ala Gln Glu Ser Glu Ala Cys Asp Thr Gln Gln Val Cys Pro Thr 
            180                 185                 190         


His Gly Ala Trp Ala Thr Trp Gly Pro Trp Thr Pro Cys Ser Ala Ser 
        195                 200                 205             


Cys His Gly Gly Pro His Glu Pro Lys Glu Thr Arg Ser Arg Lys Cys 
    210                 215                 220                 


Ser Ala Pro Glu Pro Ser Gln Lys Pro Pro Gly Lys Pro Cys Pro Gly 
225                 230                 235                 240 


Leu Ala Tyr Glu Gln Arg Arg Cys Thr Gly Leu Pro Pro Cys Pro Val 
                245                 250                 255     


Ala Gly Gly Trp Gly Pro Trp Gly Pro Val Ser Pro Cys Pro Val Thr 
            260                 265                 270         


Cys Gly Leu Gly Gln Thr Met Glu Gln Arg Thr Cys Asn His Pro Val 
        275                 280                 285             


Pro Gln His Gly Gly Pro Phe Cys Ala Gly Asp Ala Thr Arg Thr His 
    290                 295                 300                 


Ile Cys Asn Thr Ala Val Pro Cys Pro Val Asp Gly Glu Trp Asp Ser 
305                 310                 315                 320 


Trp Gly Glu Trp Ser Pro Cys Ile Arg Arg Asn Met Lys Ser Ile Ser 
                325                 330                 335     


Cys Gln Glu Ile Pro Gly Gln Gln Ser Arg Gly Arg Thr Cys Arg Gly 
            340                 345                 350         


Arg Lys Phe Asp Gly His Arg Cys Ala Gly Gln Gln Gln Asp Ile Arg 
        355                 360                 365             


His Cys Tyr Ser Ile Gln His Cys Pro Leu Lys Gly Ser Trp Ser Glu 
    370                 375                 380                 


Trp Ser Thr Trp Gly Leu Cys Met Pro Pro Cys Gly Pro Asn Pro Thr 
385                 390                 395                 400 


Arg Ala Arg Gln Arg Leu Cys Thr Pro Leu Leu Pro Lys Tyr Pro Pro 
                405                 410                 415     


Thr Val Ser Met Val Glu Gly Gln Gly Glu Lys Asn Val Thr Phe Trp 
            420                 425                 430         


Gly Arg Pro Leu Pro Arg Cys Glu Glu Leu Gln Gly Gln Lys Leu Val 
        435                 440                 445             


Val Glu Glu Lys Arg Pro Cys Leu His Val Pro Ala Cys Lys Asp Pro 
    450                 455                 460                 


Glu Glu Glu Glu Leu 
465                 


<210>  2712
<211>  62
<212>  PRT
<213>  Homo Sapiens

<400>  2712

Met Asp Tyr Tyr Arg Lys Tyr Ala Ala Ile Phe Leu Val Thr Leu Ser 
1               5                   10                  15      


Val Phe Leu His Val Leu His Ser Ala Pro Asp Val Gln Asp Cys Pro 
            20                  25                  30          


Glu Cys Thr Leu Gln Glu Asn Pro Phe Phe Ser Gln Pro Gly Ala Pro 
        35                  40                  45              


Ile Leu Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro 
    50                  55                  60          


<210>  2713
<211>  101
<212>  PRT
<213>  Homo Sapiens

<400>  2713

Met Asp Tyr Tyr Arg Lys Tyr Ala Ala Ile Phe Leu Val Thr Leu Ser 
1               5                   10                  15      


Val Phe Leu His Val Leu His Ser Ala Pro Asp Val Gln Asp Cys Pro 
            20                  25                  30          


Glu Cys Thr Leu Gln Glu Asn Pro Phe Phe Ser Gln Pro Gly Ala Pro 
        35                  40                  45              


Ile Leu Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro 
    50                  55                  60                  


Leu Arg Ser Lys Lys Thr Met Leu Val Gln Lys Asn Val Thr Ser Glu 
65                  70                  75                  80  


Ser Thr Cys Cys Val Ala Lys Ser Tyr Asn Arg Val Arg Thr Ser Arg 
                85                  90                  95      


Ser Pro Glu Ala Phe 
            100     


<210>  2714
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  2714

Met Asp Tyr Tyr Arg Lys Tyr Ala Ala Ile Phe Leu Val Thr Leu Ser 
1               5                   10                  15      


Val Phe Leu His Val Leu His Ser Ala Pro Asp Val Gln Asp Cys Pro 
            20                  25                  30          


Glu Cys Thr Leu Gln Glu Asn Pro Phe Phe Ser Gln Pro Gly Ala Pro 
        35                  40                  45              


Ile Leu Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro 
    50                  55                  60                  


Leu Arg Ser Lys Lys Thr Met Leu Val Gln Lys Asn Val Thr Ser Glu 
65                  70                  75                  80  


Ser Thr Cys Cys Val Ala Lys Ser Tyr Asn Arg Val Thr Val Met Gly 
                85                  90                  95      


Gly Phe Lys Val Glu Asn His Thr Ala Cys His Cys Ser Thr Cys Tyr 
            100                 105                 110         


Tyr His Lys Ser 
        115     


<210>  2715
<211>  147
<212>  PRT
<213>  Homo Sapiens

<400>  2715

Met Asp Tyr Tyr Arg Lys Tyr Ala Ala Ile Phe Leu Val Thr Leu Ser 
1               5                   10                  15      


Val Phe Leu His Val Leu His Ser Ala Pro Asp Val Gln Glu Thr Gly 
            20                  25                  30          


Phe His His Val Ala Gln Ala Ala Leu Lys Leu Leu Ser Ser Ser Asn 
        35                  40                  45              


Pro Pro Thr Lys Ala Ser Gln Ser Ala Arg Ile Thr Asp Cys Pro Glu 
    50                  55                  60                  


Cys Thr Leu Gln Glu Asn Pro Phe Phe Ser Gln Pro Gly Ala Pro Ile 
65                  70                  75                  80  


Leu Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Leu 
                85                  90                  95      


Arg Ser Lys Lys Thr Met Leu Val Gln Lys Asn Val Thr Ser Glu Ser 
            100                 105                 110         


Thr Cys Cys Val Ala Lys Ser Tyr Asn Arg Val Thr Val Met Gly Gly 
        115                 120                 125             


Phe Lys Val Glu Asn His Thr Ala Cys His Cys Ser Thr Cys Tyr Tyr 
    130                 135                 140                 


His Lys Ser 
145         


<210>  2716
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  2716

Met Gln Leu Ser Phe Trp Ser His Cys Arg Cys Phe Cys Met Phe Ser 
1               5                   10                  15      


Ile Pro Leu Leu Met Cys Arg Val Arg Asp Gln Ile Cys Asp Cys Pro 
            20                  25                  30          


Glu Cys Thr Leu Gln Glu Asn Pro Phe Phe Ser Gln Pro Gly Ala Pro 
        35                  40                  45              


Ile Leu Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro 
    50                  55                  60                  


Leu Arg Ser Lys Lys Thr Met Leu Val Gln Lys Asn Val Thr Ser Glu 
65                  70                  75                  80  


Ser Thr Cys Cys Val Ala Lys Ser Tyr Asn Arg Val Thr Val Met Gly 
                85                  90                  95      


Gly Phe Lys Val Glu Asn His Thr Ala Cys His Cys Ser Thr Cys Tyr 
            100                 105                 110         


Tyr His Lys Ser 
        115     


<210>  2717
<211>  130
<212>  PRT
<213>  Homo Sapiens

<400>  2717

Met Gly Gly Thr Trp Ala Ser Lys Glu Pro Leu Arg Pro Arg Cys Arg 
1               5                   10                  15      


Pro Ile Asn Ala Thr Leu Ala Val Glu Lys Glu Gly Cys Pro Val Cys 
            20                  25                  30          


Ile Thr Val Asn Thr Thr Ile Cys Ala Gly Tyr Cys Pro Thr Met Thr 
        35                  40                  45              


Arg Val Leu Gln Gly Val Leu Pro Ala Leu Pro Gln Val Val Cys Asn 
    50                  55                  60                  


Tyr Arg Asp Val Arg Phe Glu Ser Ile Arg Leu Pro Gly Cys Pro Arg 
65                  70                  75                  80  


Gly Val Asn Pro Val Val Ser Tyr Ala Val Ala Leu Ser Cys Gln Cys 
                85                  90                  95      


Ala Leu Cys Arg Arg Ser Thr Thr Asp Cys Gly Gly Pro Lys Asp His 
            100                 105                 110         


Pro Leu Thr Cys Asp Asp Pro Arg Phe Gln Asp Ser Ser Ser Ser Lys 
        115                 120                 125             


Ala Pro 
    130 


<210>  2718
<211>  155
<212>  PRT
<213>  Homo Sapiens

<400>  2718

Met Ser Lys Arg Leu Leu Leu Leu Leu Leu Leu Ser Met Gly Gly Thr 
1               5                   10                  15      


Trp Ala Ser Lys Glu Pro Leu Arg Pro Arg Cys Arg Pro Ile Asn Ala 
            20                  25                  30          


Thr Leu Ala Val Glu Lys Glu Gly Cys Pro Val Cys Ile Thr Val Asn 
        35                  40                  45              


Thr Thr Ile Cys Ala Gly Tyr Cys Pro Thr Met Thr Arg Val Leu Gln 
    50                  55                  60                  


Gly Val Leu Pro Ala Leu Pro Gln Val Val Cys Asn Tyr Arg Asp Val 
65                  70                  75                  80  


Arg Phe Glu Ser Ile Arg Leu Pro Gly Cys Pro Arg Gly Val Asn Pro 
                85                  90                  95      


Val Val Ser Tyr Ala Val Ala Leu Ser Cys Gln Cys Ala Leu Cys Arg 
            100                 105                 110         


Arg Ser Thr Thr Asp Cys Gly Gly Pro Lys Asp His Pro Leu Thr Cys 
        115                 120                 125             


Asp Asp Pro Arg Phe Gln Asp Ser Ser Ser Ser Lys Ala Pro Pro Pro 
    130                 135                 140                 


Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro 
145                 150                 155 


<210>  2719
<211>  130
<212>  PRT
<213>  Homo Sapiens

<400>  2719

Met Gly Gly Thr Trp Ala Ser Lys Glu Pro Leu Arg Pro Arg Cys Arg 
1               5                   10                  15      


Pro Ile Asn Ala Thr Leu Ala Val Glu Lys Glu Gly Cys Pro Val Cys 
            20                  25                  30          


Ile Thr Val Asn Thr Thr Ile Cys Ala Gly Tyr Cys Pro Thr Met Thr 
        35                  40                  45              


Arg Val Leu Gln Gly Val Leu Pro Ala Leu Pro Gln Val Val Cys Asn 
    50                  55                  60                  


Tyr Arg Asp Val Arg Phe Glu Ser Ile Arg Leu Pro Gly Cys Pro Arg 
65                  70                  75                  80  


Gly Val Asn Pro Val Val Ser Tyr Ala Val Ala Leu Ser Cys Gln Cys 
                85                  90                  95      


Ala Leu Cys Arg Arg Ser Thr Thr Asp Cys Gly Gly Pro Lys Asp His 
            100                 105                 110         


Pro Leu Thr Cys Asp Asp Pro Arg Phe Gln Ala Ser Ser Ser Ser Lys 
        115                 120                 125             


Ala Pro 
    130 


<210>  2720
<211>  163
<212>  PRT
<213>  Homo Sapiens

<400>  2720

Met Ser Lys Gly Leu Leu Leu Leu Leu Leu Leu Ser Met Gly Gly Thr 
1               5                   10                  15      


Trp Ala Ser Lys Glu Pro Leu Arg Pro Arg Cys Arg Pro Ile Asn Ala 
            20                  25                  30          


Thr Leu Ala Val Glu Lys Glu Gly Cys Pro Val Cys Ile Thr Val Asn 
        35                  40                  45              


Thr Thr Ile Cys Ala Gly Tyr Cys Pro Thr Met Thr Arg Val Leu Gln 
    50                  55                  60                  


Gly Val Leu Pro Ala Leu Pro Gln Val Val Cys Asn Tyr Arg Asp Val 
65                  70                  75                  80  


Arg Phe Glu Ser Ile Arg Leu Pro Gly Cys Pro Arg Gly Val Asn Pro 
                85                  90                  95      


Val Val Ser Tyr Ala Val Ala Leu Ser Cys Gln Cys Ala Leu Cys Arg 
            100                 105                 110         


Arg Ser Thr Thr Asp Cys Gly Gly Pro Lys Asp His Pro Leu Thr Cys 
        115                 120                 125             


Asp Asp Pro Arg Phe Gln Ala Ser Ser Ser Ser Lys Ala Pro Pro Pro 
    130                 135                 140                 


Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile 
145                 150                 155                 160 


Leu Pro Gln 
            


<210>  2721
<211>  165
<212>  PRT
<213>  Homo Sapiens

<400>  2721

Met Glu Met Phe Gln Gly Leu Leu Leu Leu Leu Leu Leu Ser Met Gly 
1               5                   10                  15      


Gly Thr Trp Ala Ser Lys Glu Pro Leu Arg Pro Arg Cys Arg Pro Ile 
            20                  25                  30          


Asn Ala Thr Leu Ala Val Glu Lys Glu Gly Cys Pro Val Cys Ile Thr 
        35                  40                  45              


Val Asn Thr Thr Ile Cys Ala Gly Tyr Cys Pro Thr Met Thr Arg Val 
    50                  55                  60                  


Leu Gln Gly Val Leu Pro Ala Leu Pro Gln Val Val Cys Asn Tyr Arg 
65                  70                  75                  80  


Asp Val Arg Phe Glu Ser Ile Arg Leu Pro Gly Cys Pro Arg Gly Val 
                85                  90                  95      


Asn Pro Val Val Ser Tyr Ala Val Ala Leu Ser Cys Gln Cys Ala Leu 
            100                 105                 110         


Cys Arg Arg Ser Thr Thr Asp Cys Gly Gly Pro Lys Asp His Pro Leu 
        115                 120                 125             


Thr Cys Asp Asp Pro Arg Phe Gln Asp Ser Ser Ser Ser Lys Ala Pro 
    130                 135                 140                 


Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr 
145                 150                 155                 160 


Pro Ile Leu Pro Gln 
                165 


<210>  2722
<211>  165
<212>  PRT
<213>  Homo Sapiens

<400>  2722

Met Glu Met Phe Gln Gly Leu Leu Leu Leu Leu Leu Leu Ser Met Gly 
1               5                   10                  15      


Gly Thr Trp Ala Ser Lys Glu Pro Leu Arg Pro Arg Cys Arg Pro Ile 
            20                  25                  30          


Asn Ala Thr Leu Ala Val Glu Lys Glu Gly Cys Pro Val Cys Ile Thr 
        35                  40                  45              


Val Asn Thr Thr Ile Cys Ala Gly Tyr Cys Pro Thr Met Thr Arg Val 
    50                  55                  60                  


Leu Gln Gly Val Leu Pro Ala Leu Pro Gln Val Val Cys Asn Tyr Arg 
65                  70                  75                  80  


Asp Val Arg Phe Glu Ser Ile Arg Leu Pro Gly Cys Pro Arg Gly Val 
                85                  90                  95      


Asn Pro Val Val Ser Tyr Ala Val Ala Leu Ser Cys Gln Cys Ala Leu 
            100                 105                 110         


Cys Arg Arg Ser Thr Thr Asp Cys Gly Gly Pro Lys Asp His Pro Leu 
        115                 120                 125             


Thr Cys Asp Asp Pro Arg Phe Gln Asp Ser Ser Ser Ser Lys Ala Pro 
    130                 135                 140                 


Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr 
145                 150                 155                 160 


Pro Ile Leu Pro Gln 
                165 


<210>  2723
<211>  165
<212>  PRT
<213>  Homo Sapiens

<400>  2723

Met Glu Met Phe Gln Gly Leu Leu Leu Leu Leu Leu Leu Ser Met Gly 
1               5                   10                  15      


Gly Thr Trp Ala Ser Arg Glu Met Leu Arg Pro Arg Cys Arg Pro Ile 
            20                  25                  30          


Asn Ala Thr Leu Ala Val Glu Lys Glu Gly Cys Pro Val Cys Ile Thr 
        35                  40                  45              


Val Asn Thr Thr Ile Cys Ala Gly Tyr Cys Pro Thr Met Thr Arg Val 
    50                  55                  60                  


Leu Gln Gly Val Leu Pro Ala Leu Pro Gln Val Val Cys Asn Tyr Arg 
65                  70                  75                  80  


Asp Val Arg Phe Glu Ser Ile Arg Leu Pro Gly Cys Pro Arg Gly Val 
                85                  90                  95      


Asn Pro Val Val Ser Tyr Ala Val Ala Leu Ser Cys Gln Cys Ala Leu 
            100                 105                 110         


Cys Arg Arg Ser Thr Thr Asp Cys Gly Gly Pro Lys Asp His Pro Leu 
        115                 120                 125             


Thr Cys Asp Asp Pro Arg Phe Gln Ala Ser Ser Ser Ser Lys Ala Pro 
    130                 135                 140                 


Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr 
145                 150                 155                 160 


Pro Ile Leu Pro Gln 
                165 


<210>  2724
<211>  165
<212>  PRT
<213>  Homo Sapiens

<400>  2724

Met Glu Met Phe Gln Gly Leu Leu Leu Leu Leu Leu Leu Ser Met Gly 
1               5                   10                  15      


Gly Thr Trp Ala Ser Arg Glu Met Leu Arg Pro Arg Cys Arg Pro Ile 
            20                  25                  30          


Asn Ala Thr Leu Ala Val Glu Lys Glu Gly Cys Pro Val Cys Ile Thr 
        35                  40                  45              


Val Asn Thr Thr Ile Cys Ala Gly Tyr Cys Pro Thr Met Thr Arg Val 
    50                  55                  60                  


Leu Gln Gly Val Leu Pro Ala Leu Pro Gln Val Val Cys Asn Tyr Arg 
65                  70                  75                  80  


Asp Val Arg Phe Glu Ser Ile Arg Leu Pro Gly Cys Pro Arg Gly Val 
                85                  90                  95      


Asn Pro Val Val Ser Tyr Ala Val Ala Leu Ser Cys Gln Cys Ala Leu 
            100                 105                 110         


Cys Arg Arg Ser Thr Thr Asp Cys Gly Gly Pro Lys Asp His Pro Leu 
        115                 120                 125             


Thr Cys Asp Asp Pro Arg Phe Gln Ala Ser Ser Ser Ser Lys Ala Pro 
    130                 135                 140                 


Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr 
145                 150                 155                 160 


Pro Ile Leu Pro Gln 
                165 


<210>  2725
<211>  165
<212>  PRT
<213>  Homo Sapiens

<400>  2725

Met Glu Met Phe Gln Gly Leu Leu Leu Leu Leu Leu Leu Ser Met Gly 
1               5                   10                  15      


Gly Thr Trp Ala Ser Arg Glu Met Leu Arg Pro Arg Cys Arg Pro Ile 
            20                  25                  30          


Asn Ala Thr Leu Ala Val Glu Lys Glu Gly Cys Pro Val Cys Ile Thr 
        35                  40                  45              


Val Asn Thr Thr Ile Cys Ala Gly Tyr Cys Pro Thr Met Thr Arg Val 
    50                  55                  60                  


Leu Gln Gly Val Leu Pro Ala Leu Pro Gln Val Val Cys Asn Tyr Arg 
65                  70                  75                  80  


Asp Val Arg Phe Glu Ser Ile Arg Leu Pro Gly Cys Pro Arg Gly Val 
                85                  90                  95      


Asn Pro Val Val Ser Tyr Ala Val Ala Leu Ser Cys Gln Cys Ala Leu 
            100                 105                 110         


Cys Arg Arg Ser Thr Thr Asp Cys Gly Gly Pro Lys Asp His Pro Leu 
        115                 120                 125             


Thr Cys Asp Asp Pro Arg Phe Gln Ala Ser Ser Ser Ser Lys Ala Pro 
    130                 135                 140                 


Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr 
145                 150                 155                 160 


Pro Ile Leu Pro Gln 
                165 


<210>  2726
<211>  165
<212>  PRT
<213>  Homo Sapiens

<400>  2726

Met Glu Met Phe Gln Gly Leu Leu Leu Leu Leu Leu Leu Ser Met Gly 
1               5                   10                  15      


Gly Thr Trp Ala Ser Lys Glu Pro Leu Arg Pro Arg Cys Arg Pro Ile 
            20                  25                  30          


Asn Ala Thr Leu Ala Val Glu Lys Glu Gly Cys Pro Val Cys Ile Thr 
        35                  40                  45              


Val Asn Thr Thr Ile Cys Ala Gly Tyr Cys Pro Thr Met Thr Arg Val 
    50                  55                  60                  


Leu Gln Gly Val Leu Pro Ala Leu Pro Gln Val Val Cys Asn Tyr Arg 
65                  70                  75                  80  


Asp Val Arg Phe Glu Ser Ile Arg Leu Pro Gly Cys Pro Arg Gly Val 
                85                  90                  95      


Asn Pro Val Val Ser Tyr Ala Val Ala Leu Ser Cys Gln Cys Ala Leu 
            100                 105                 110         


Cys Arg Arg Ser Thr Thr Asp Cys Gly Gly Pro Lys Asp His Pro Leu 
        115                 120                 125             


Thr Cys Asp Asp Pro Arg Phe Gln Asp Ser Ser Ser Ser Lys Ala Pro 
    130                 135                 140                 


Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr 
145                 150                 155                 160 


Pro Ile Leu Pro Gln 
                165 


<210>  2727
<211>  132
<212>  PRT
<213>  Homo Sapiens

<400>  2727

Met Leu Pro Leu Thr Met Thr Val Leu Ile Leu Leu Leu Leu Pro Thr 
1               5                   10                  15      


Gly Gln Ala Ala Pro Lys Asp Gly Val Thr Arg Pro Asp Ser Glu Val 
            20                  25                  30          


Gln His Gln Leu Leu Pro Asn Pro Phe Gln Pro Gly Gln Glu Gln Leu 
        35                  40                  45              


Gly Leu Leu Gln Ser Tyr Leu Lys Gly Leu Gly Arg Thr Glu Val Gln 
    50                  55                  60                  


Leu Glu His Leu Ser Arg Glu Gln Val Leu Leu Tyr Leu Phe Ala Leu 
65                  70                  75                  80  


His Asp Tyr Asp Gln Ser Gly Gln Leu Asp Gly Leu Glu Leu Leu Ser 
                85                  90                  95      


Met Leu Thr Ala Ala Leu Ala Pro Gly Ala Ala Asn Ser Pro Thr Thr 
            100                 105                 110         


Asn Pro Gly Asn Leu Asp Ala Arg Leu Asp Gly Gly Glu Lys Ala Met 
        115                 120                 125             


Gln Pro Gln Trp 
    130         


<210>  2728
<211>  301
<212>  PRT
<213>  Homo Sapiens

<400>  2728

Met Leu Pro Leu Thr Met Thr Val Leu Ile Leu Leu Leu Leu Pro Thr 
1               5                   10                  15      


Gly Gln Ala Ala Pro Lys Asp Gly Val Thr Arg Pro Asp Ser Glu Val 
            20                  25                  30          


Gln His Gln Leu Leu Pro Asn Pro Phe Gln Pro Gly Gln Glu Gln Leu 
        35                  40                  45              


Gly Leu Leu Gln Ser Tyr Leu Lys Gly Leu Gly Arg Thr Glu Val Gln 
    50                  55                  60                  


Leu Glu His Leu Ser Arg Glu Gln Val Leu Leu Tyr Leu Phe Ala Leu 
65                  70                  75                  80  


His Asp Tyr Asp Gln Ser Gly Gln Leu Asp Gly Leu Glu Leu Leu Ser 
                85                  90                  95      


Met Leu Thr Ala Ala Leu Ala Pro Gly Ala Ala Asn Ser Pro Thr Thr 
            100                 105                 110         


Asn Pro Val Ile Leu Ile Val Asp Lys Val Leu Glu Thr Gln Asp Leu 
        115                 120                 125             


Asn Gly Asp Gly Leu Met Thr Pro Ala Glu Leu Ile Asn Phe Pro Gly 
    130                 135                 140                 


Val Ala Leu Arg His Val Glu Pro Gly Glu Pro Leu Ala Pro Ser Pro 
145                 150                 155                 160 


Gln Glu Pro Gln Ala Val Gly Arg Gln Ser Leu Leu Ala Lys Ser Pro 
                165                 170                 175     


Leu Arg Gln Glu Thr Gln Glu Ala Pro Gly Pro Arg Glu Glu Ala Lys 
            180                 185                 190         


Gly Gln Val Glu Ala Arg Arg Glu Ser Leu Asp Pro Val Gln Glu Pro 
        195                 200                 205             


Gly Gly Gln Ala Glu Ala Asp Gly Asp Val Pro Gly Pro Arg Gly Glu 
    210                 215                 220                 


Ala Glu Gly Gln Ala Glu Ala Lys Gly Asp Ala Pro Gly Pro Arg Gly 
225                 230                 235                 240 


Glu Ala Gly Gly Gln Ala Glu Ala Glu Gly Asp Ala Pro Gly Pro Arg 
                245                 250                 255     


Gly Glu Ala Gly Gly Gln Ala Glu Ala Arg Glu Asn Gly Glu Glu Ala 
            260                 265                 270         


Lys Glu Leu Pro Gly Glu Thr Leu Glu Ser Lys Asn Thr Gln Asn Asp 
        275                 280                 285             


Phe Glu Val His Ile Val Gln Val Glu Asn Asp Glu Ile 
    290                 295                 300     


<210>  2729
<211>  318
<212>  PRT
<213>  Homo Sapiens

<400>  2729

Met Leu Pro Leu Thr Met Thr Val Leu Ile Leu Leu Leu Leu Pro Thr 
1               5                   10                  15      


Gly Gln Ala Ala Pro Lys Asp Gly Val Thr Arg Pro Asp Ser Glu Val 
            20                  25                  30          


Gln His Gln Leu Leu Pro Asn Pro Phe Gln Pro Gly Gln Glu Gln Leu 
        35                  40                  45              


Gly Leu Leu Gln Ser Tyr Leu Lys Gly Leu Gly Arg Thr Glu Val Gln 
    50                  55                  60                  


Leu Glu His Leu Ser Arg Glu Gln Val Leu Leu Tyr Leu Phe Ala Leu 
65                  70                  75                  80  


His Asp Tyr Asp Gln Ser Gly Gln Leu Asp Gly Leu Glu Leu Leu Ser 
                85                  90                  95      


Met Leu Thr Ala Ala Leu Ala Pro Gly Ala Ala Asn Ser Pro Thr Thr 
            100                 105                 110         


Asn Pro Val Ile Leu Ile Val Asp Lys Val Leu Glu Thr Gln Asp Leu 
        115                 120                 125             


Asn Gly Asp Gly Leu Met Thr Pro Ala Glu Leu Ile Asn Phe Pro Gly 
    130                 135                 140                 


Val Ala Leu Arg His Val Glu Pro Gly Glu Pro Leu Ala Pro Ser Pro 
145                 150                 155                 160 


Gln Glu Pro Gln Ala Val Gly Arg Gln Ser Leu Leu Ala Lys Ser Pro 
                165                 170                 175     


Leu Arg Gln Glu Thr Gln Glu Ala Pro Gly Pro Arg Glu Glu Ala Lys 
            180                 185                 190         


Gly Gln Val Glu Ala Arg Arg Glu Ser Leu Asp Pro Val Gln Glu Pro 
        195                 200                 205             


Gly Gly Gln Ala Glu Ala Asp Gly Asp Val Pro Gly Pro Arg Gly Glu 
    210                 215                 220                 


Ala Glu Gly Gln Ala Glu Ala Lys Gly Asp Ala Pro Gly Pro Arg Gly 
225                 230                 235                 240 


Glu Ala Gly Gly Gln Ala Glu Ala Glu Gly Asp Ala Pro Gly Pro Arg 
                245                 250                 255     


Gly Glu Ala Gly Gly Gln Ala Glu Ala Glu Gly Asp Ala Pro Gly Pro 
            260                 265                 270         


Arg Gly Glu Ala Gly Gly Gln Ala Glu Ala Arg Glu Asn Gly Glu Glu 
        275                 280                 285             


Ala Lys Glu Leu Pro Gly Glu Thr Leu Glu Ser Lys Asn Thr Gln Asn 
    290                 295                 300                 


Asp Phe Glu Val His Ile Val Gln Val Glu Asn Asp Glu Ile 
305                 310                 315             


<210>  2730
<211>  318
<212>  PRT
<213>  Homo Sapiens

<400>  2730

Met Leu Pro Leu Thr Met Thr Val Leu Ile Leu Leu Leu Leu Pro Thr 
1               5                   10                  15      


Gly Gln Ala Ala Pro Lys Asp Gly Val Thr Arg Pro Asp Ser Glu Val 
            20                  25                  30          


Gln His Gln Leu Leu Pro Asn Pro Phe Gln Pro Gly Gln Glu Gln Leu 
        35                  40                  45              


Gly Leu Leu Gln Ser Tyr Leu Lys Gly Leu Gly Arg Thr Glu Val Gln 
    50                  55                  60                  


Leu Glu His Leu Ser Arg Glu Gln Val Leu Leu Tyr Leu Phe Ala Leu 
65                  70                  75                  80  


His Asp Tyr Asp Gln Ser Gly Gln Leu Asp Gly Leu Glu Leu Leu Ser 
                85                  90                  95      


Met Leu Thr Ala Ala Leu Ala Pro Gly Ala Ala Asn Ser Pro Thr Thr 
            100                 105                 110         


Asn Pro Val Ile Leu Ile Val Asp Lys Val Leu Glu Thr Gln Asp Leu 
        115                 120                 125             


Asn Gly Asp Gly Leu Met Thr Pro Ala Glu Leu Ile Asn Phe Pro Gly 
    130                 135                 140                 


Val Ala Leu Arg His Val Glu Pro Gly Glu Pro Leu Ala Pro Ser Pro 
145                 150                 155                 160 


Gln Glu Pro Gln Ala Val Gly Arg Gln Ser Leu Leu Ala Lys Ser Pro 
                165                 170                 175     


Leu Arg Gln Glu Thr Gln Glu Ala Pro Gly Pro Arg Glu Glu Ala Lys 
            180                 185                 190         


Gly Gln Val Glu Ala Arg Arg Glu Ser Leu Asp Pro Val Gln Glu Pro 
        195                 200                 205             


Gly Gly Gln Ala Glu Ala Asp Gly Asp Val Pro Gly Pro Arg Gly Glu 
    210                 215                 220                 


Ala Glu Gly Gln Ala Glu Ala Lys Gly Asp Ala Pro Gly Pro Arg Gly 
225                 230                 235                 240 


Glu Ala Gly Gly Gln Ala Glu Ala Glu Gly Asp Ala Pro Gly Pro Arg 
                245                 250                 255     


Gly Glu Ala Gly Gly Gln Ala Glu Ala Glu Gly Asp Ala Pro Gly Pro 
            260                 265                 270         


Arg Gly Glu Ala Gly Gly Gln Ala Glu Ala Arg Glu Asn Gly Glu Glu 
        275                 280                 285             


Ala Lys Glu Leu Pro Gly Glu Thr Leu Glu Ser Lys Asn Thr Gln Asn 
    290                 295                 300                 


Asp Phe Glu Val His Ile Val Gln Val Glu Asn Asp Glu Ile 
305                 310                 315             


<210>  2731
<211>  318
<212>  PRT
<213>  Homo Sapiens

<400>  2731

Met Leu Pro Leu Thr Met Thr Val Leu Ile Leu Leu Leu Leu Pro Thr 
1               5                   10                  15      


Gly Gln Ala Ala Pro Lys Asp Gly Val Thr Arg Pro Asp Ser Glu Val 
            20                  25                  30          


Gln His Gln Leu Leu Pro Asn Pro Phe Gln Pro Gly Gln Glu Gln Leu 
        35                  40                  45              


Gly Leu Leu Gln Ser Tyr Leu Lys Gly Leu Gly Arg Thr Glu Val Gln 
    50                  55                  60                  


Leu Glu His Leu Ser Arg Glu Gln Val Leu Leu Tyr Leu Phe Ala Leu 
65                  70                  75                  80  


His Asp Tyr Asp Gln Ser Gly Gln Leu Asp Gly Leu Glu Leu Leu Ser 
                85                  90                  95      


Met Leu Thr Ala Ala Leu Ala Pro Gly Ala Ala Asn Ser Pro Thr Thr 
            100                 105                 110         


Asn Pro Val Ile Leu Ile Val Asp Lys Val Leu Glu Thr Gln Asp Leu 
        115                 120                 125             


Asn Gly Asp Gly Leu Met Thr Pro Ala Glu Leu Ile Asn Phe Pro Gly 
    130                 135                 140                 


Val Ala Leu Arg His Val Glu Pro Gly Glu Pro Leu Ala Pro Ser Pro 
145                 150                 155                 160 


Gln Glu Pro Gln Ala Val Gly Arg Gln Ser Leu Leu Ala Lys Ser Pro 
                165                 170                 175     


Leu Arg Gln Glu Thr Gln Glu Ala Pro Gly Pro Arg Glu Glu Ala Lys 
            180                 185                 190         


Gly Gln Val Glu Ala Arg Arg Glu Ser Leu Asp Pro Val Gln Glu Pro 
        195                 200                 205             


Gly Gly Gln Ala Glu Ala Asp Gly Asp Val Pro Gly Pro Arg Gly Glu 
    210                 215                 220                 


Ala Glu Gly Gln Ala Glu Ala Lys Gly Asp Ala Pro Gly Pro Arg Gly 
225                 230                 235                 240 


Glu Ala Gly Gly Gln Ala Glu Ala Glu Gly Asp Ala Pro Gly Pro Arg 
                245                 250                 255     


Gly Glu Ala Gly Gly Gln Ala Glu Ala Glu Gly Asp Ala Pro Gly Pro 
            260                 265                 270         


Arg Gly Glu Ala Gly Gly Gln Ala Glu Ala Arg Glu Asn Gly Glu Glu 
        275                 280                 285             


Ala Lys Glu Leu Pro Gly Glu Thr Leu Glu Ser Lys Asn Thr Gln Asn 
    290                 295                 300                 


Asp Phe Glu Val His Ile Val Gln Val Glu Asn Asp Glu Ile 
305                 310                 315             


<210>  2732
<211>  57
<212>  PRT
<213>  Homo Sapiens

<400>  2732

Met Leu Pro Leu Thr Met Thr Val Leu Ile Leu Leu Leu Leu Pro Thr 
1               5                   10                  15      


Gly Gln Ala Ala Pro Lys Asp Gly Val Thr Arg Pro Asp Ser Glu Val 
            20                  25                  30          


Gln His Gln Leu Leu Pro Asn Pro Phe Gln Pro Gly Gln Glu Gln Leu 
        35                  40                  45              


Gly Ser Pro Leu Pro Leu Cys Pro Pro 
    50                  55          


<210>  2733
<211>  112
<212>  PRT
<213>  Homo Sapiens

<400>  2733

Met Leu Thr Ala Ala Leu Ala Pro Gly Ala Ala Asn Ser Pro Thr Thr 
1               5                   10                  15      


Asn Pro Val Ile Leu Ile Val Asp Lys Val Leu Glu Thr Gln Asp Leu 
            20                  25                  30          


Asn Gly Asp Gly Leu Met Thr Pro Ala Glu Leu Ile Asn Phe Pro Gly 
        35                  40                  45              


Val Ala Leu Arg Pro Tyr Pro Pro Tyr Ile Gly Val Gly Pro Asn Ser 
    50                  55                  60                  


Asn Met Cys Ser Arg Ser Asp Leu Pro Glu Asp Ser Asn Thr Leu Tyr 
65                  70                  75                  80  


Pro Gly Ser His Leu Trp Leu Arg His Ala Leu Asn Ser Lys Gly Asn 
                85                  90                  95      


Leu Asp Ala Arg Leu Asp Gly Gly Glu Lys Ala Met Gln Pro Gln Trp 
            100                 105                 110         


<210>  2734
<211>  440
<212>  PRT
<213>  Homo Sapiens

<400>  2734

Met Asn Gly Leu Lys Glu Val Arg Tyr Ala Cys Ala Val Leu Leu Trp 
1               5                   10                  15      


Ala Pro Trp His Leu Val Gly Ser Lys Gly Met Gly Arg Gly Val Gly 
            20                  25                  30          


Met Arg Pro Gln Leu Cys Phe Arg His Ser Arg Pro Ala Phe Met Cys 
        35                  40                  45              


Phe Ile Tyr Lys Ser Trp Ser Asp Ile Tyr Phe Glu His Ser Ser Met 
    50                  55                  60                  


Gly Ser Leu Leu Ser Val Cys Glu Ser Ser Leu Ser Arg Ser Pro Val 
65                  70                  75                  80  


Phe Gly Ala Ala Gly Arg Ser Arg Gln Lys Met Arg Leu Cys Leu Thr 
                85                  90                  95      


Gln Pro Ile Cys Asp Thr Val Ala Asp Ala Ser Phe Pro Arg Pro Leu 
            100                 105                 110         


Ile Leu Phe Leu Val Pro Val Pro Gly Arg Met Leu Pro Leu Thr Met 
        115                 120                 125             


Thr Val Leu Ile Leu Leu Leu Leu Pro Thr Gly Gln Ala Ala Pro Lys 
    130                 135                 140                 


Asp Gly Val Thr Arg Pro Asp Ser Glu Val Gln His Gln Leu Leu Pro 
145                 150                 155                 160 


Asn Pro Phe Gln Pro Gly Gln Glu Gln Leu Gly Leu Leu Gln Ser Tyr 
                165                 170                 175     


Leu Lys Gly Leu Gly Arg Thr Glu Val Gln Leu Glu His Leu Ser Arg 
            180                 185                 190         


Glu Gln Val Leu Leu Tyr Leu Phe Ala Leu His Asp Tyr Asp Gln Ser 
        195                 200                 205             


Gly Gln Leu Asp Gly Leu Glu Leu Leu Ser Met Leu Thr Ala Ala Leu 
    210                 215                 220                 


Ala Pro Gly Ala Ala Asn Ser Pro Thr Thr Asn Pro Val Ile Leu Ile 
225                 230                 235                 240 


Val Asp Lys Val Leu Glu Thr Gln Asp Leu Asn Gly Asp Gly Leu Met 
                245                 250                 255     


Thr Pro Ala Glu Leu Ile Asn Phe Pro Gly Val Ala Leu Arg His Val 
            260                 265                 270         


Glu Pro Gly Glu Pro Leu Ala Pro Ser Pro Gln Glu Pro Gln Ala Val 
        275                 280                 285             


Gly Arg Gln Ser Leu Leu Ala Lys Ser Pro Leu Arg Gln Glu Thr Gln 
    290                 295                 300                 


Glu Ala Pro Gly Pro Arg Glu Glu Ala Lys Gly Gln Val Glu Ala Arg 
305                 310                 315                 320 


Arg Glu Ser Leu Asp Pro Val Gln Glu Pro Gly Gly Gln Ala Glu Ala 
                325                 330                 335     


Asp Gly Asp Val Pro Gly Pro Arg Gly Glu Ala Glu Gly Gln Ala Glu 
            340                 345                 350         


Ala Lys Gly Asp Ala Pro Gly Pro Arg Gly Glu Ala Gly Gly Gln Ala 
        355                 360                 365             


Glu Ala Glu Gly Asp Ala Pro Gly Pro Arg Gly Glu Ala Gly Gly Gln 
    370                 375                 380                 


Ala Glu Ala Glu Gly Asp Ala Pro Gly Pro Arg Gly Glu Ala Gly Gly 
385                 390                 395                 400 


Gln Ala Glu Ala Arg Glu Asn Gly Glu Glu Ala Lys Glu Leu Pro Gly 
                405                 410                 415     


Glu Thr Leu Glu Ser Lys Asn Thr Gln Asn Asp Phe Glu Val His Ile 
            420                 425                 430         


Val Gln Val Glu Asn Asp Glu Ile 
        435                 440 


<210>  2735
<211>  359
<212>  PRT
<213>  Homo Sapiens

<400>  2735

Met Val Arg Pro Met Leu Leu Leu Ser Leu Gly Leu Leu Ala Gly Leu 
1               5                   10                  15      


Leu Pro Ala Leu Ala Ala Cys Pro Gln Asn Cys His Cys His Ser Asp 
            20                  25                  30          


Leu Gln His Val Ile Cys Asp Lys Val Gly Leu Gln Lys Ile Pro Lys 
        35                  40                  45              


Val Ser Glu Lys Thr Lys Leu Leu Asn Leu Gln Arg Asn Asn Phe Pro 
    50                  55                  60                  


Val Leu Ala Ala Asn Ser Phe Arg Ala Met Pro Asn Leu Val Ser Leu 
65                  70                  75                  80  


His Leu Gln His Cys Gln Ile Arg Glu Val Ala Ala Gly Ala Phe Arg 
                85                  90                  95      


Gly Leu Lys Gln Leu Ile Tyr Leu Tyr Leu Ser His Asn Asp Ile Arg 
            100                 105                 110         


Val Leu Arg Ala Gly Ala Phe Asp Asp Leu Thr Glu Leu Thr Tyr Leu 
        115                 120                 125             


Tyr Leu Asp His Asn Lys Val Thr Glu Leu Pro Arg Gly Leu Leu Ser 
    130                 135                 140                 


Pro Leu Val Asn Leu Phe Ile Leu Gln Leu Asn Asn Asn Lys Ile Arg 
145                 150                 155                 160 


Glu Leu Arg Ala Gly Ala Phe Gln Gly Ala Lys Asp Leu Arg Trp Leu 
                165                 170                 175     


Tyr Leu Ser Glu Asn Ala Leu Ser Ser Leu Gln Pro Gly Ala Leu Asp 
            180                 185                 190         


Asp Val Glu Asn Leu Ala Lys Phe His Val Asp Arg Asn Gln Leu Ser 
        195                 200                 205             


Ser Tyr Pro Ser Ala Ala Leu Ser Lys Leu Arg Val Val Glu Glu Leu 
    210                 215                 220                 


Lys Leu Ser His Asn Pro Leu Lys Ser Ile Pro Asp Asn Ala Phe Gln 
225                 230                 235                 240 


Ser Phe Gly Arg Tyr Leu Glu Thr Leu Trp Leu Asp Asn Thr Asn Leu 
                245                 250                 255     


Glu Lys Phe Ser Asp Gly Ala Phe Leu Gly Val Thr Thr Leu Lys His 
            260                 265                 270         


Val His Leu Glu Asn Asn Arg Leu Asn Gln Leu Pro Ser Asn Phe Pro 
        275                 280                 285             


Phe Asp Ser Leu Glu Thr Leu Ala Leu Thr Asn Asn Pro Trp Lys Cys 
    290                 295                 300                 


Thr Cys Gln Leu Arg Gly Leu Arg Arg Trp Leu Glu Ala Lys Ala Ser 
305                 310                 315                 320 


Arg Pro Asp Ala Thr Cys Ala Ser Pro Ala Lys Phe Lys Gly Gln His 
                325                 330                 335     


Ile Arg Asp Thr Asp Ala Phe Arg Ser Cys Lys Phe Pro Thr Lys Arg 
            340                 345                 350         


Ser Lys Lys Ala Gly Arg His 
        355                 


<210>  2736
<211>  359
<212>  PRT
<213>  Homo Sapiens

<400>  2736

Met Val Arg Pro Met Leu Leu Leu Ser Leu Gly Leu Leu Ala Gly Leu 
1               5                   10                  15      


Leu Pro Ala Leu Ala Ala Cys Pro Gln Asn Cys His Cys His Ser Asp 
            20                  25                  30          


Leu Gln His Val Ile Cys Asp Lys Val Gly Leu Gln Lys Ile Pro Lys 
        35                  40                  45              


Val Ser Glu Lys Thr Lys Leu Leu Asn Leu Gln Arg Asn Asn Phe Pro 
    50                  55                  60                  


Val Leu Ala Ala Asn Ser Phe Arg Ala Met Pro Asn Leu Val Ser Leu 
65                  70                  75                  80  


His Leu Gln His Cys Gln Ile Arg Glu Val Ala Ala Gly Ala Phe Arg 
                85                  90                  95      


Gly Leu Lys Gln Leu Ile Tyr Leu Tyr Leu Ser His Asn Asp Ile Arg 
            100                 105                 110         


Val Leu Arg Ala Gly Ala Phe Asp Asp Leu Thr Glu Leu Thr Tyr Leu 
        115                 120                 125             


Tyr Leu Asp His Asn Lys Val Thr Glu Leu Pro Arg Gly Leu Leu Ser 
    130                 135                 140                 


Pro Leu Val Asn Leu Phe Ile Leu Gln Leu Asn Asn Asn Lys Ile Arg 
145                 150                 155                 160 


Glu Leu Arg Ala Gly Ala Phe Gln Gly Ala Lys Asp Leu Arg Trp Leu 
                165                 170                 175     


Tyr Leu Ser Glu Asn Ala Leu Ser Ser Leu Gln Pro Gly Ala Leu Asp 
            180                 185                 190         


Asp Val Glu Asn Leu Ala Lys Phe His Val Asp Arg Asn Gln Leu Ser 
        195                 200                 205             


Ser Tyr Pro Ser Ala Ala Leu Ser Lys Leu Arg Val Val Glu Glu Leu 
    210                 215                 220                 


Lys Leu Ser His Asn Pro Leu Lys Ser Ile Pro Asp Asn Ala Phe Gln 
225                 230                 235                 240 


Ser Phe Gly Arg Tyr Leu Glu Thr Leu Trp Leu Asp Asn Thr Asn Leu 
                245                 250                 255     


Glu Lys Phe Ser Asp Gly Ala Phe Leu Gly Val Thr Thr Leu Lys His 
            260                 265                 270         


Val His Leu Glu Asn Asn Arg Leu Asn Gln Leu Pro Ser Asn Phe Pro 
        275                 280                 285             


Phe Asp Ser Leu Glu Thr Leu Ala Leu Thr Asn Asn Pro Trp Lys Cys 
    290                 295                 300                 


Thr Cys Gln Leu Arg Gly Leu Arg Arg Trp Leu Glu Ala Lys Ala Ser 
305                 310                 315                 320 


Arg Pro Asp Ala Thr Cys Ala Ser Pro Ala Lys Phe Lys Gly Gln His 
                325                 330                 335     


Ile Arg Asp Thr Asp Ala Phe Arg Ser Cys Lys Phe Pro Thr Lys Arg 
            340                 345                 350         


Ser Lys Lys Ala Gly Arg His 
        355                 


<210>  2737
<211>  42
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2737

Xaa Ala Ser Arg Pro Asp Ala Thr Cys Ala Ser Pro Ala Lys Phe Lys 
1               5                   10                  15      


Gly Gln His Ile Arg Asp Thr Asp Ala Phe Arg Ser Cys Lys Phe Pro 
            20                  25                  30          


Thr Lys Arg Ser Lys Lys Ala Gly Arg His 
        35                  40          


<210>  2738
<211>  762
<212>  PRT
<213>  Homo Sapiens

<400>  2738

Met Glu Gly Pro Arg Ser Ser Thr His Val Pro Leu Val Leu Pro Leu 
1               5                   10                  15      


Leu Val Leu Leu Leu Leu Ala Pro Ala Arg Gln Ala Ala Ala Gln Arg 
            20                  25                  30          


Cys Pro Gln Ala Cys Ile Cys Asp Asn Ser Arg Arg His Val Ala Cys 
        35                  40                  45              


Arg Tyr Gln Asn Leu Thr Glu Val Pro Asp Ala Ile Pro Glu Leu Thr 
    50                  55                  60                  


Gln Arg Leu Asp Leu Gln Gly Asn Leu Leu Lys Val Ile Pro Ala Ala 
65                  70                  75                  80  


Ala Phe Gln Gly Val Pro His Leu Thr His Leu Asp Leu Arg His Cys 
                85                  90                  95      


Glu Val Glu Leu Val Ala Glu Gly Ala Phe Arg Gly Leu Gly Arg Leu 
            100                 105                 110         


Leu Leu Leu Asn Leu Ala Ser Asn His Leu Arg Glu Leu Pro Gln Glu 
        115                 120                 125             


Ala Leu Asp Gly Leu Gly Ser Leu Arg Arg Leu Glu Leu Glu Gly Asn 
    130                 135                 140                 


Ala Leu Glu Glu Leu Arg Pro Gly Thr Phe Gly Ala Leu Gly Ala Leu 
145                 150                 155                 160 


Ala Thr Leu Asn Leu Ala His Asn Ala Leu Val Tyr Leu Pro Ala Met 
                165                 170                 175     


Ala Phe Gln Gly Leu Leu Arg Val Arg Trp Leu Arg Leu Ser His Asn 
            180                 185                 190         


Ala Leu Ser Val Leu Ala Pro Glu Ala Leu Ala Gly Leu Pro Ala Leu 
        195                 200                 205             


Arg Arg Leu Ser Leu His His Asn Glu Leu Gln Ala Leu Pro Gly Pro 
    210                 215                 220                 


Val Leu Ser Gln Ala Arg Gly Leu Ala Arg Leu Glu Leu Gly His Asn 
225                 230                 235                 240 


Pro Leu Thr Tyr Ala Gly Glu Glu Asp Gly Leu Ala Leu Pro Gly Leu 
                245                 250                 255     


Arg Glu Leu Leu Leu Asp Gly Gly Ala Leu Gln Ala Leu Gly Pro Arg 
            260                 265                 270         


Ala Phe Ala His Cys Pro Arg Leu His Thr Leu Asp Leu Arg Gly Asn 
        275                 280                 285             


Gln Leu Asp Thr Leu Pro Pro Leu Gln Gly Pro Gly Gln Leu Arg Arg 
    290                 295                 300                 


Leu Arg Leu Gln Gly Asn Pro Leu Trp Cys Gly Cys Gln Ala Arg Pro 
305                 310                 315                 320 


Leu Leu Glu Trp Leu Ala Arg Ala Arg Val Arg Ser Asp Gly Ala Cys 
                325                 330                 335     


Gln Gly Pro Arg Arg Leu Arg Gly Glu Ala Leu Asp Ala Leu Arg Pro 
            340                 345                 350         


Trp Asp Leu Arg Cys Pro Gly Asp Ala Ala Gln Glu Glu Glu Glu Leu 
        355                 360                 365             


Glu Glu Arg Ala Val Ala Gly Pro Arg Ala Pro Pro Arg Gly Pro Pro 
    370                 375                 380                 


Arg Gly Pro Gly Glu Glu Arg Ala Val Ala Pro Cys Pro Arg Ala Cys 
385                 390                 395                 400 


Val Cys Val Pro Glu Ser Arg His Ser Ser Cys Glu Gly Cys Gly Leu 
                405                 410                 415     


Gln Ala Val Pro Arg Gly Phe Pro Ser Asp Thr Gln Leu Leu Asp Leu 
            420                 425                 430         


Arg Arg Asn His Phe Pro Ser Val Pro Arg Ala Ala Phe Pro Gly Leu 
        435                 440                 445             


Gly His Leu Val Ser Leu His Leu Gln His Cys Gly Ile Ala Glu Leu 
    450                 455                 460                 


Glu Ala Gly Ala Leu Ala Gly Leu Gly Arg Leu Ile Tyr Leu Tyr Leu 
465                 470                 475                 480 


Ser Asp Asn Gln Leu Ala Gly Leu Ser Ala Ala Ala Leu Glu Gly Ala 
                485                 490                 495     


Pro Arg Leu Gly Tyr Leu Tyr Leu Glu Arg Asn Arg Phe Leu Gln Val 
            500                 505                 510         


Pro Gly Ala Ala Leu Arg Ala Leu Pro Ser Leu Phe Ser Leu His Leu 
        515                 520                 525             


Gln Asp Asn Ala Val Asp Arg Leu Ala Pro Gly Asp Leu Gly Arg Thr 
    530                 535                 540                 


Arg Ala Leu Arg Trp Val Tyr Leu Ser Gly Asn Arg Ile Thr Glu Val 
545                 550                 555                 560 


Ser Leu Gly Ala Leu Gly Pro Ala Arg Glu Leu Glu Lys Leu His Leu 
                565                 570                 575     


Asp Arg Asn Gln Leu Arg Glu Val Pro Thr Gly Ala Leu Glu Gly Leu 
            580                 585                 590         


Pro Ala Leu Leu Glu Leu Gln Leu Ser Gly Asn Pro Leu Arg Ala Leu 
        595                 600                 605             


Arg Asp Gly Ala Phe Gln Pro Val Gly Arg Ser Leu Gln His Leu Phe 
    610                 615                 620                 


Leu Asn Ser Ser Gly Leu Glu Gln Ile Cys Pro Gly Ala Phe Ser Gly 
625                 630                 635                 640 


Leu Gly Pro Gly Leu Gln Ser Leu His Leu Gln Lys Asn Gln Leu Arg 
                645                 650                 655     


Ala Leu Pro Ala Leu Pro Ser Leu Ser Gln Leu Glu Leu Ile Asp Leu 
            660                 665                 670         


Ser Ser Asn Pro Phe His Cys Asp Cys Gln Leu Leu Pro Leu His Arg 
        675                 680                 685             


Trp Leu Thr Gly Leu Asn Leu Arg Val Gly Ala Thr Cys Ala Thr Pro 
    690                 695                 700                 


Pro Asn Ala Arg Gly Gln Arg Val Lys Ala Ala Ala Ala Val Phe Glu 
705                 710                 715                 720 


Asp Cys Pro Gly Trp Ala Ala Arg Lys Ala Lys Arg Thr Pro Ala Ser 
                725                 730                 735     


Arg Pro Ser Ala Arg Arg Thr Pro Ile Lys Gly Arg Gln Cys Gly Ala 
            740                 745                 750         


Asp Lys Val Gly Lys Glu Lys Gly Arg Leu 
        755                 760         


<210>  2739
<211>  253
<212>  PRT
<213>  Homo Sapiens

<400>  2739

Ser Ser Arg Arg His Gly Gly Val Ser Leu Trp Ala Arg Trp Cys Lys 
1               5                   10                  15      


Gly Gly Phe Arg Ala Ala Gln Trp Pro Gln Asp Asn Ala Val Asp Arg 
            20                  25                  30          


Leu Ala Pro Gly Asp Leu Gly Arg Thr Arg Ala Leu Arg Trp Val Tyr 
        35                  40                  45              


Leu Ser Gly Asn Arg Ile Thr Glu Val Ser Leu Gly Ala Leu Gly Pro 
    50                  55                  60                  


Ala Arg Glu Leu Glu Lys Leu His Leu Asp Arg Asn Gln Leu Arg Glu 
65                  70                  75                  80  


Val Pro Thr Gly Ala Leu Glu Gly Leu Pro Ala Leu Leu Glu Leu Gln 
                85                  90                  95      


Leu Ser Gly Asn Pro Leu Arg Ala Leu Arg Asp Gly Ala Phe Gln Pro 
            100                 105                 110         


Val Gly Arg Ser Leu Gln His Leu Phe Leu Asn Ser Ser Gly Leu Glu 
        115                 120                 125             


Gln Ile Cys Pro Gly Ala Phe Ser Gly Leu Gly Pro Gly Leu Gln Ser 
    130                 135                 140                 


Leu His Leu Gln Lys Asn Gln Leu Arg Ala Leu Pro Ala Leu Pro Ser 
145                 150                 155                 160 


Leu Ser Gln Leu Glu Leu Ile Asp Leu Ser Ser Asn Pro Phe His Cys 
                165                 170                 175     


Asp Cys Gln Leu Leu Pro Leu His Arg Trp Leu Thr Gly Leu Asn Leu 
            180                 185                 190         


Arg Val Gly Ala Thr Cys Ala Thr Pro Pro Asn Ala Arg Gly Gln Arg 
        195                 200                 205             


Val Lys Ala Ala Ala Ala Val Phe Glu Asp Cys Pro Gly Trp Ala Ala 
    210                 215                 220                 


Arg Lys Ala Lys Arg Thr Pro Ala Ser Arg Pro Ser Ala Arg Arg Thr 
225                 230                 235                 240 


Pro Ile Lys Gly Arg Gln Cys Gly Ala Asp Lys Val Gly 
                245                 250             


<210>  2740
<211>  684
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2740

Xaa Pro Arg Ser Ser Thr His Val Pro Leu Val Leu Pro Leu Leu Val 
1               5                   10                  15      


Leu Leu Leu Leu Ala Pro Ala Arg Gln Ala Ala Ala Gln Arg Cys Pro 
            20                  25                  30          


Gln Ala Cys Ile Cys Asp Asn Ser Arg Arg His Val Ala Cys Arg Tyr 
        35                  40                  45              


Gln Asn Leu Thr Glu Val Pro Asp Ala Ile Pro Glu Leu Thr Gln Arg 
    50                  55                  60                  


Leu Asp Leu Gln Gly Asn Leu Leu Lys Val Ile Pro Ala Ala Ala Phe 
65                  70                  75                  80  


Gln Gly Val Pro His Leu Thr His Leu Asp Leu Arg His Cys Glu Val 
                85                  90                  95      


Glu Leu Val Ala Glu Gly Ala Phe Arg Gly Leu Gly Arg Leu Leu Leu 
            100                 105                 110         


Leu Asn Leu Ala Ser Asn His Leu Arg Glu Leu Pro Gln Glu Ala Leu 
        115                 120                 125             


Asp Gly Leu Gly Ser Leu Arg Arg Leu Glu Leu Glu Gly Asn Ala Leu 
    130                 135                 140                 


Glu Glu Leu Arg Pro Gly Thr Phe Gly Ala Leu Gly Ala Leu Ala Thr 
145                 150                 155                 160 


Leu Asn Leu Ala His Asn Ala Leu Val Tyr Leu Pro Ala Met Ala Phe 
                165                 170                 175     


Gln Gly Leu Leu Arg Val Arg Trp Leu Arg Leu Ser His Asn Ala Leu 
            180                 185                 190         


Ser Val Leu Ala Pro Glu Ala Leu Ala Gly Leu Pro Ala Leu Arg Arg 
        195                 200                 205             


Leu Ser Leu His His Asn Glu Leu Gln Ala Leu Pro Gly Pro Val Leu 
    210                 215                 220                 


Ser Gln Ala Arg Gly Leu Ala Arg Leu Glu Leu Gly His Asn Pro Leu 
225                 230                 235                 240 


Thr Tyr Ala Gly Glu Glu Asp Gly Leu Ala Leu Pro Gly Leu Arg Glu 
                245                 250                 255     


Leu Leu Leu Asp Gly Gly Ala Leu Gln Ala Leu Gly Pro Arg Ala Phe 
            260                 265                 270         


Ala His Cys Pro Arg Leu His Thr Leu Asp Leu Arg Gly Asn Gln Leu 
        275                 280                 285             


Asp Thr Leu Pro Pro Leu Gln Gly Pro Gly Gln Leu Arg Arg Leu Arg 
    290                 295                 300                 


Leu Gln Gly Asn Pro Leu Trp Cys Gly Cys Gln Ala Arg Pro Leu Leu 
305                 310                 315                 320 


Glu Trp Leu Ala Arg Ala Arg Val Arg Ser Asp Gly Ala Cys Gln Gly 
                325                 330                 335     


Pro Arg Arg Leu Arg Gly Glu Ala Leu Asp Ala Leu Arg Pro Trp Asp 
            340                 345                 350         


Leu Arg Cys Pro Gly Asp Ala Ala Gln Glu Glu Glu Glu Leu Glu Glu 
        355                 360                 365             


Arg Ala Val Ala Gly Pro Arg Ala Pro Pro Arg Gly Pro Pro Arg Gly 
    370                 375                 380                 


Pro Gly Glu Glu Arg Ala Val Ala Pro Cys Pro Arg Ala Cys Val Cys 
385                 390                 395                 400 


Val Pro Glu Ser Arg His Ser Ser Cys Glu Gly Cys Gly Leu Gln Ala 
                405                 410                 415     


Val Pro Arg Gly Phe Pro Ser Asp Thr Gln Leu Leu Asp Leu Arg Arg 
            420                 425                 430         


Asn His Phe Pro Ser Val Pro Arg Ala Ala Phe Pro Gly Leu Gly His 
        435                 440                 445             


Leu Val Ser Leu His Leu Gln His Cys Gly Ile Ala Glu Leu Glu Ala 
    450                 455                 460                 


Gly Ala Leu Ala Gly Leu Gly Arg Leu Ile Tyr Leu Tyr Leu Ser Asp 
465                 470                 475                 480 


Asn Gln Leu Ala Gly Leu Ser Ala Ala Ala Leu Glu Gly Ala Pro Arg 
                485                 490                 495     


Leu Gly Tyr Leu Tyr Leu Glu Arg Asn Arg Phe Leu Gln Val Pro Gly 
            500                 505                 510         


Ala Ala Leu Arg Ala Leu Pro Ser Leu Phe Ser Leu His Leu Gln Asp 
        515                 520                 525             


Asn Ala Val Asp Arg Leu Ala Pro Gly Asp Leu Gly Arg Thr Arg Ala 
    530                 535                 540                 


Leu Arg Trp Val Tyr Leu Ser Gly Asn Arg Ile Thr Glu Val Ser Leu 
545                 550                 555                 560 


Gly Ala Leu Gly Pro Ala Arg Glu Leu Glu Lys Leu His Leu Asp Arg 
                565                 570                 575     


Asn Gln Leu Arg Glu Val Pro Thr Gly Ala Leu Glu Gly Leu Pro Ala 
            580                 585                 590         


Leu Leu Glu Leu Gln Leu Ser Gly Asn Pro Leu Arg Ala Leu Arg Asp 
        595                 600                 605             


Gly Ala Phe Gln Pro Val Gly Arg Ser Leu Gln His Leu Phe Leu Asn 
    610                 615                 620                 


Ser Ser Gly Leu Glu Gln Ile Cys Pro Gly Ala Phe Ser Gly Leu Gly 
625                 630                 635                 640 


Pro Gly Leu Gln Ser Leu His Leu Gln Lys Asn Gln Leu Arg Ala Leu 
                645                 650                 655     


Pro Ala Leu Pro Ser Ala Arg Arg Thr Pro Ile Lys Gly Arg Gln Cys 
            660                 665                 670         


Gly Ala Asp Lys Val Gly Lys Glu Lys Gly Arg Leu 
        675                 680                 


<210>  2741
<211>  57
<212>  PRT
<213>  Homo Sapiens

<400>  2741

Phe Arg Glu Val Gly Pro Lys Asn Ser Tyr Ile Ala Tyr Ile Glu Asp 
1               5                   10                  15      


His Ser Gly Asn Gly Thr Phe Val Asn Thr Glu Leu Val Gly Lys Gly 
            20                  25                  30          


Lys Arg Arg Pro Leu Asn Asn Asn Ser Glu Ile Ala Leu Ser Leu Ser 
        35                  40                  45              


Arg Asn Lys Val Val Pro Val Glu Arg 
    50                  55          


<210>  2742
<211>  137
<212>  PRT
<213>  Homo Sapiens

<400>  2742

Met Glu Arg Leu Leu Tyr Gly Ile Gly Ala Cys Gly Glu Val Lys Leu 
1               5                   10                  15      


Ala Phe Glu Arg Lys Thr Cys Lys Lys Val Ala Ile Lys Ile Ile Ser 
            20                  25                  30          


Lys Arg Lys Phe Ala Ile Gly Ser Ala Arg Glu Ala Asp Pro Ala Leu 
        35                  40                  45              


Asn Val Glu Thr Glu Ile Glu Ile Leu Lys Lys Leu Asn His Pro Cys 
    50                  55                  60                  


Ile Ile Lys Ile Lys Asn Phe Phe Asp Ala Glu Asp Tyr Tyr Ile Val 
65                  70                  75                  80  


Leu Glu Leu Met Glu Gly Gly Glu Leu Phe Asp Lys Val Val Gly Asn 
                85                  90                  95      


Lys Arg Leu Lys Glu Ala Thr Cys Lys Leu Tyr Phe Tyr Gln Met Leu 
            100                 105                 110         


Leu Ala Val Gln Tyr Leu His Glu Asn Gly Ile Ile His Arg Asp Leu 
        115                 120                 125             


Lys Pro Glu Asn Val Leu Leu Ser Ser 
    130                 135         


<210>  2743
<211>  172
<212>  PRT
<213>  Homo Sapiens

<400>  2743

Met Leu Arg Leu Leu Thr Ser Met Val Val Met Ser Arg Glu Ser Asp 
1               5                   10                  15      


Val Glu Ala Gln Gln Ser His Gly Ser Ser Ala Cys Ser Gln Pro His 
            20                  25                  30          


Gly Ser Val Thr Gln Ser Gln Gly Ser Ser Ser Gln Ser Gln Gly Ile 
        35                  40                  45              


Ser Ser Ser Ser Thr Ser Thr Met Pro Asn Ser Ser Gln Ser Ser His 
    50                  55                  60                  


Ser Ser Ser Gly Thr Leu Ser Ser Leu Glu Thr Val Ser Thr Gln Glu 
65                  70                  75                  80  


Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro Glu Asp Gln Glu Pro Glu 
                85                  90                  95      


Glu Pro Thr Pro Ala Pro Trp Ala Arg Leu Trp Ala Leu Gln Asp Gly 
            100                 105                 110         


Phe Ala Asn Leu Glu Cys Val Asn Asp Asn Tyr Trp Phe Gly Arg Asp 
        115                 120                 125             


Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro Leu Leu Lys Arg Thr Asp 
    130                 135                 140                 


Lys Tyr Arg Thr Tyr Ser Lys Lys His Phe Arg Ile Phe Arg Glu Val 
145                 150                 155                 160 


Gly Pro Lys Asn Ser Tyr Ile Ala Tyr Ile Glu Asp 
                165                 170         


<210>  2744
<211>  121
<212>  PRT
<213>  Homo Sapiens

<400>  2744

Met Ser Lys Thr Leu Gly Ser Gly Ala Cys Gly Glu Val Lys Leu Ala 
1               5                   10                  15      


Phe Glu Arg Lys Thr Cys Lys Lys Val Ala Ile Lys Ile Ile Ser Lys 
            20                  25                  30          


Arg Lys Phe Ala Ile Gly Ser Ala Arg Glu Ala Asp Pro Ala Leu Asn 
        35                  40                  45              


Val Glu Thr Glu Ile Glu Ile Leu Lys Lys Leu Asn His Pro Cys Ile 
    50                  55                  60                  


Ile Lys Ile Lys Asn Phe Phe Asp Ala Glu Asp Tyr Tyr Ile Val Leu 
65                  70                  75                  80  


Glu Leu Met Glu Gly Gly Glu Leu Phe Asp Lys Val Val Gly Asn Lys 
                85                  90                  95      


Arg Leu Lys Glu Ala Thr Cys Lys Leu Tyr Phe Tyr Gln Met Leu Leu 
            100                 105                 110         


Ala Val Gln Tyr Leu His Glu Asn Gly 
        115                 120     


<210>  2745
<211>  161
<212>  PRT
<213>  Homo Sapiens

<400>  2745

Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Thr Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Thr Ser Thr Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Thr Leu Ser Ser Leu Glu 
    50                  55                  60                  


Thr Val Ser Thr Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro 
65                  70                  75                  80  


Glu Asp Gln Glu Pro Glu Glu Pro Thr Pro Ala Pro Trp Ala Arg Leu 
                85                  90                  95      


Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Glu Cys Val Asn Asp Asn 
            100                 105                 110         


Tyr Trp Phe Gly Arg Asp Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro 
        115                 120                 125             


Leu Leu Lys Arg Thr Asp Lys Tyr Arg Thr Tyr Ser Lys Lys His Phe 
    130                 135                 140                 


Arg Ile Phe Arg Glu Glu Asn Leu Ser Cys Pro Tyr Arg Ile Trp Phe 
145                 150                 155                 160 


Lys 
    


<210>  2746
<211>  165
<212>  PRT
<213>  Homo Sapiens

<400>  2746

Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Thr Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Thr Ser Thr Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Thr Leu Ser Ser Leu Glu 
    50                  55                  60                  


Thr Val Ser Thr Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro 
65                  70                  75                  80  


Glu Asp Gln Glu Pro Glu Glu Pro Thr Pro Ala Pro Trp Ala Arg Leu 
                85                  90                  95      


Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Glu Cys Val Asn Asp Asn 
            100                 105                 110         


Tyr Trp Phe Gly Arg Asp Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro 
        115                 120                 125             


Leu Leu Lys Arg Thr Asp Lys Tyr Arg Thr Tyr Ser Lys Lys His Phe 
    130                 135                 140                 


Arg Ile Phe Arg Glu Glu Asn Leu Ser Cys Pro Tyr Arg Ile Trp Phe 
145                 150                 155                 160 


Asn Phe Cys Leu Phe 
                165 


<210>  2747
<211>  298
<212>  PRT
<213>  Homo Sapiens

<400>  2747

Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Thr Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Thr Ser Thr Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Thr Leu Ser Ser Leu Glu 
    50                  55                  60                  


Thr Val Ser Thr Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro 
65                  70                  75                  80  


Glu Asp Gln Glu Pro Glu Glu Pro Thr Pro Ala Pro Trp Ala Arg Leu 
                85                  90                  95      


Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Glu Cys Val Asn Asp Asn 
            100                 105                 110         


Tyr Trp Phe Gly Arg Asp Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro 
        115                 120                 125             


Leu Leu Lys Arg Thr Asp Lys Tyr Arg Thr Tyr Ser Lys Lys His Phe 
    130                 135                 140                 


Arg Ile Phe Arg Glu Glu Asn Leu Ser Cys Pro Tyr Arg Ile Trp Phe 
145                 150                 155                 160 


Asn Gly Ala Cys Gly Glu Val Lys Leu Ala Phe Glu Arg Lys Thr Cys 
                165                 170                 175     


Lys Lys Val Ala Ile Lys Ile Ile Ser Lys Arg Lys Phe Ala Ile Gly 
            180                 185                 190         


Ser Ala Arg Glu Ala Asp Pro Ala Leu Asn Val Glu Thr Glu Ile Glu 
        195                 200                 205             


Ile Leu Lys Lys Leu Asn His Pro Cys Ile Ile Lys Ile Lys Asn Phe 
    210                 215                 220                 


Phe Asp Ala Glu Asp Tyr Tyr Ile Val Leu Glu Leu Met Glu Gly Gly 
225                 230                 235                 240 


Glu Leu Phe Asp Lys Val Val Gly Asn Lys Arg Leu Lys Glu Ala Thr 
                245                 250                 255     


Cys Lys Leu Tyr Phe Tyr Gln Met Leu Leu Ala Val Gln Tyr Leu His 
            260                 265                 270         


Glu Asn Gly Ile Ile His Arg Asp Leu Lys Pro Glu Asn Val Leu Leu 
        275                 280                 285             


Ser Ser Gln Glu Glu Asp Cys Leu Ile Lys 
    290                 295             


<210>  2748
<211>  207
<212>  PRT
<213>  Homo Sapiens

<400>  2748

Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Thr Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Thr Ser Thr Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Thr Leu Ser Ser Leu Glu 
    50                  55                  60                  


Thr Val Ser Thr Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro 
65                  70                  75                  80  


Glu Asp Gln Glu Pro Glu Glu Pro Thr Pro Ala Pro Trp Ala Arg Leu 
                85                  90                  95      


Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Glu Cys Val Asn Asp Asn 
            100                 105                 110         


Tyr Trp Phe Gly Arg Asp Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro 
        115                 120                 125             


Leu Leu Lys Arg Thr Asp Lys Tyr Arg Thr Tyr Ser Lys Lys His Phe 
    130                 135                 140                 


Arg Ile Phe Arg Glu Val Gly Pro Lys Asn Ser Tyr Ile Ala Tyr Ile 
145                 150                 155                 160 


Glu Asp His Ser Gly Asn Gly Thr Phe Val Asn Thr Glu Leu Val Gly 
                165                 170                 175     


Lys Gly Lys Arg Arg Pro Leu Asn Asn Asn Ser Glu Ile Ala Leu Ser 
            180                 185                 190         


Leu Ser Arg Asn Lys Glu Lys Ile Leu Lys Ile Tyr Ser Leu Ser 
        195                 200                 205         


<210>  2749
<211>  207
<212>  PRT
<213>  Homo Sapiens

<400>  2749

Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Thr Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Thr Ser Thr Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Thr Leu Ser Ser Leu Glu 
    50                  55                  60                  


Thr Val Ser Thr Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro 
65                  70                  75                  80  


Glu Asp Gln Glu Pro Glu Glu Pro Thr Pro Ala Pro Trp Ala Arg Leu 
                85                  90                  95      


Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Glu Cys Val Asn Asp Asn 
            100                 105                 110         


Tyr Trp Phe Gly Arg Asp Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro 
        115                 120                 125             


Leu Leu Lys Arg Thr Asp Lys Tyr Arg Thr Tyr Ser Lys Lys His Phe 
    130                 135                 140                 


Arg Ile Phe Arg Glu Val Gly Pro Lys Asn Ser Tyr Ile Ala Tyr Ile 
145                 150                 155                 160 


Glu Asp His Ser Gly Asn Gly Thr Phe Val Asn Thr Glu Leu Val Gly 
                165                 170                 175     


Lys Gly Lys Arg Arg Pro Leu Asn Asn Asn Ser Glu Ile Ala Leu Ser 
            180                 185                 190         


Leu Ser Arg Asn Lys Glu Lys Ile Leu Lys Ile Tyr Ser Leu Ser 
        195                 200                 205         


<210>  2750
<211>  514
<212>  PRT
<213>  Homo Sapiens

<400>  2750

Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Thr Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Thr Ser Thr Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Thr Leu Ser Ser Leu Glu 
    50                  55                  60                  


Thr Val Ser Thr Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro 
65                  70                  75                  80  


Glu Asp Gln Glu Pro Glu Glu Pro Thr Pro Ala Pro Trp Ala Arg Leu 
                85                  90                  95      


Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Glu Cys Val Asn Asp Asn 
            100                 105                 110         


Tyr Trp Phe Gly Arg Asp Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro 
        115                 120                 125             


Leu Leu Lys Arg Thr Asp Lys Tyr Arg Thr Tyr Ser Lys Lys His Phe 
    130                 135                 140                 


Arg Ile Phe Arg Glu Val Gly Pro Lys Asn Ser Tyr Ile Ala Tyr Ile 
145                 150                 155                 160 


Glu Asp His Ser Gly Asn Gly Thr Phe Val Asn Thr Glu Leu Val Gly 
                165                 170                 175     


Lys Gly Lys Arg Arg Pro Leu Asn Asn Asn Ser Glu Ile Ala Leu Ser 
            180                 185                 190         


Leu Ser Arg Asn Lys Val Phe Val Phe Phe Asp Leu Thr Val Asp Asp 
        195                 200                 205             


Gln Ser Val Tyr Pro Lys Ala Leu Arg Asp Glu Tyr Ile Met Ser Lys 
    210                 215                 220                 


Thr Leu Gly Ser Gly Ala Cys Gly Glu Val Lys Leu Ala Phe Glu Arg 
225                 230                 235                 240 


Lys Thr Cys Lys Lys Val Ala Ile Lys Ile Ile Ser Lys Arg Lys Phe 
                245                 250                 255     


Ala Ile Gly Ser Ala Arg Glu Ala Asp Pro Ala Leu Asn Val Glu Thr 
            260                 265                 270         


Glu Ile Glu Ile Leu Lys Lys Leu Asn His Pro Cys Ile Ile Lys Ile 
        275                 280                 285             


Lys Asn Phe Phe Asp Ala Glu Asp Tyr Tyr Ile Val Leu Glu Leu Met 
    290                 295                 300                 


Glu Gly Gly Glu Leu Phe Asp Lys Val Val Gly Asn Lys Arg Leu Lys 
305                 310                 315                 320 


Glu Ala Thr Cys Lys Leu Tyr Phe Tyr Gln Met Leu Leu Ala Val Gln 
                325                 330                 335     


Ile Thr Asp Phe Gly His Ser Lys Ile Leu Gly Glu Thr Ser Leu Met 
            340                 345                 350         


Arg Thr Leu Cys Gly Thr Pro Thr Tyr Leu Ala Pro Glu Val Leu Val 
        355                 360                 365             


Ser Val Gly Thr Ala Gly Tyr Asn Arg Ala Val Asp Cys Trp Ser Leu 
    370                 375                 380                 


Gly Val Ile Leu Phe Ile Cys Leu Ser Gly Tyr Pro Pro Phe Ser Glu 
385                 390                 395                 400 


His Arg Thr Gln Val Ser Leu Lys Asp Gln Ile Thr Ser Gly Lys Tyr 
                405                 410                 415     


Asn Phe Ile Pro Glu Val Trp Ala Glu Val Ser Glu Lys Ala Leu Asp 
            420                 425                 430         


Leu Val Lys Lys Leu Leu Val Val Asp Pro Lys Ala Arg Phe Thr Thr 
        435                 440                 445             


Glu Glu Ala Leu Arg His Pro Trp Leu Gln Asp Glu Asp Met Lys Arg 
    450                 455                 460                 


Lys Phe Gln Asp Leu Leu Ser Glu Glu Asn Glu Ser Thr Ala Leu Pro 
465                 470                 475                 480 


Gln Val Leu Ala Gln Pro Ser Thr Ser Arg Lys Arg Pro Arg Glu Gly 
                485                 490                 495     


Glu Ala Glu Gly Ala Glu Thr Thr Lys Arg Pro Ala Val Cys Ala Ala 
            500                 505                 510         


Val Leu 
        


<210>  2751
<211>  543
<212>  PRT
<213>  Homo Sapiens

<400>  2751

Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Thr Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Thr Ser Thr Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Thr Leu Ser Ser Leu Glu 
    50                  55                  60                  


Thr Val Ser Thr Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro 
65                  70                  75                  80  


Glu Asp Gln Glu Pro Glu Glu Pro Thr Pro Ala Pro Trp Ala Arg Leu 
                85                  90                  95      


Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Glu Cys Val Asn Asp Asn 
            100                 105                 110         


Tyr Trp Phe Gly Arg Asp Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro 
        115                 120                 125             


Leu Leu Lys Arg Thr Asp Lys Tyr Arg Thr Tyr Ser Lys Lys His Phe 
    130                 135                 140                 


Arg Ile Phe Arg Glu Val Gly Pro Lys Asn Ser Tyr Ile Ala Tyr Ile 
145                 150                 155                 160 


Glu Asp His Ser Gly Asn Gly Thr Phe Val Asn Thr Glu Leu Val Gly 
                165                 170                 175     


Lys Gly Lys Arg Arg Pro Leu Asn Asn Asn Ser Glu Ile Ala Leu Ser 
            180                 185                 190         


Leu Ser Arg Asn Lys Val Phe Val Phe Phe Asp Leu Thr Val Asp Asp 
        195                 200                 205             


Gln Ser Val Tyr Pro Lys Ala Leu Arg Asp Glu Tyr Ile Met Ser Lys 
    210                 215                 220                 


Thr Leu Gly Ser Gly Ala Cys Gly Glu Val Lys Leu Ala Phe Glu Arg 
225                 230                 235                 240 


Lys Thr Cys Lys Lys Val Ala Ile Lys Ile Ile Ser Lys Arg Lys Phe 
                245                 250                 255     


Ala Ile Gly Ser Ala Arg Glu Ala Asp Pro Ala Leu Asn Val Glu Thr 
            260                 265                 270         


Glu Ile Glu Ile Leu Lys Lys Leu Asn His Pro Cys Ile Ile Lys Ile 
        275                 280                 285             


Lys Asn Phe Phe Asp Ala Glu Asp Tyr Tyr Ile Val Leu Glu Leu Met 
    290                 295                 300                 


Glu Gly Gly Glu Leu Phe Asp Lys Val Val Gly Asn Lys Arg Leu Lys 
305                 310                 315                 320 


Glu Ala Thr Cys Lys Leu Tyr Phe Tyr Gln Met Leu Leu Ala Val Gln 
                325                 330                 335     


Tyr Leu His Glu Asn Gly Ile Ile His Arg Asp Leu Lys Pro Glu Asn 
            340                 345                 350         


Val Leu Leu Ser Ser Gln Glu Glu Asp Cys Leu Ile Lys Ile Thr Asp 
        355                 360                 365             


Phe Gly His Ser Lys Ile Leu Gly Glu Thr Ser Leu Met Arg Thr Leu 
    370                 375                 380                 


Cys Gly Thr Pro Thr Tyr Leu Ala Pro Glu Val Leu Val Ser Val Gly 
385                 390                 395                 400 


Thr Ala Gly Tyr Asn Arg Ala Val Asp Cys Trp Ser Leu Gly Val Ile 
                405                 410                 415     


Leu Phe Ile Cys Leu Ser Gly Tyr Pro Pro Phe Ser Glu His Arg Thr 
            420                 425                 430         


Gln Val Ser Leu Lys Asp Gln Ile Thr Ser Gly Lys Tyr Asn Phe Ile 
        435                 440                 445             


Pro Glu Val Trp Ala Glu Val Ser Glu Lys Ala Leu Asp Leu Val Lys 
    450                 455                 460                 


Lys Leu Leu Val Val Asp Pro Lys Ala Arg Phe Thr Thr Glu Glu Ala 
465                 470                 475                 480 


Leu Arg His Pro Trp Leu Gln Asp Glu Asp Met Lys Arg Lys Phe Gln 
                485                 490                 495     


Asp Leu Leu Ser Glu Glu Asn Glu Ser Thr Ala Leu Pro Gln Val Leu 
            500                 505                 510         


Ala Gln Pro Ser Thr Ser Arg Lys Arg Pro Arg Glu Gly Glu Ala Glu 
        515                 520                 525             


Gly Ala Glu Thr Thr Lys Arg Pro Ala Val Cys Ala Ala Val Leu 
    530                 535                 540             


<210>  2752
<211>  514
<212>  PRT
<213>  Homo Sapiens

<400>  2752

Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Thr Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Thr Ser Thr Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Thr Leu Ser Ser Leu Glu 
    50                  55                  60                  


Thr Val Ser Thr Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro 
65                  70                  75                  80  


Glu Asp Gln Glu Pro Glu Glu Pro Thr Pro Ala Pro Trp Ala Arg Leu 
                85                  90                  95      


Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Glu Cys Val Asn Asp Asn 
            100                 105                 110         


Tyr Trp Phe Gly Arg Asp Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro 
        115                 120                 125             


Leu Leu Lys Arg Thr Asp Lys Tyr Arg Thr Tyr Ser Lys Lys His Phe 
    130                 135                 140                 


Arg Ile Phe Arg Glu Val Gly Pro Lys Asn Ser Tyr Ile Ala Tyr Ile 
145                 150                 155                 160 


Glu Asp His Ser Gly Asn Gly Thr Phe Val Asn Thr Glu Leu Val Gly 
                165                 170                 175     


Lys Gly Lys Arg Arg Pro Leu Asn Asn Asn Ser Glu Ile Ala Leu Ser 
            180                 185                 190         


Leu Ser Arg Asn Lys Val Phe Val Phe Phe Asp Leu Thr Val Asp Asp 
        195                 200                 205             


Gln Ser Val Tyr Pro Lys Ala Leu Arg Asp Glu Tyr Ile Met Ser Lys 
    210                 215                 220                 


Thr Leu Gly Ser Gly Ala Cys Gly Glu Val Lys Leu Ala Phe Glu Arg 
225                 230                 235                 240 


Lys Thr Cys Lys Lys Val Ala Ile Lys Ile Ile Ser Lys Arg Lys Phe 
                245                 250                 255     


Ala Ile Gly Ser Ala Arg Glu Ala Asp Pro Ala Leu Asn Val Glu Thr 
            260                 265                 270         


Glu Ile Glu Ile Leu Lys Lys Leu Asn His Pro Cys Ile Ile Lys Ile 
        275                 280                 285             


Lys Asn Phe Phe Asp Ala Glu Asp Tyr Tyr Ile Val Leu Glu Leu Met 
    290                 295                 300                 


Glu Gly Gly Glu Leu Phe Asp Lys Val Val Gly Asn Lys Arg Leu Lys 
305                 310                 315                 320 


Glu Ala Thr Cys Lys Leu Tyr Phe Tyr Gln Met Leu Leu Ala Val Gln 
                325                 330                 335     


Ile Thr Asp Phe Gly His Ser Lys Ile Leu Gly Glu Thr Ser Leu Met 
            340                 345                 350         


Arg Thr Leu Cys Gly Thr Pro Thr Tyr Leu Ala Pro Glu Val Leu Val 
        355                 360                 365             


Ser Val Gly Thr Ala Gly Tyr Asn Arg Ala Val Asp Cys Trp Ser Leu 
    370                 375                 380                 


Gly Val Ile Leu Phe Ile Cys Leu Ser Gly Tyr Pro Pro Phe Ser Glu 
385                 390                 395                 400 


His Arg Thr Gln Val Ser Leu Lys Asp Gln Ile Thr Ser Gly Lys Tyr 
                405                 410                 415     


Asn Phe Ile Pro Glu Val Trp Ala Glu Val Ser Glu Lys Ala Leu Asp 
            420                 425                 430         


Leu Val Lys Lys Leu Leu Val Val Asp Pro Lys Ala Arg Phe Thr Thr 
        435                 440                 445             


Glu Glu Ala Leu Arg His Pro Trp Leu Gln Asp Glu Asp Met Lys Arg 
    450                 455                 460                 


Lys Phe Gln Asp Leu Leu Ser Glu Glu Asn Glu Ser Thr Ala Leu Pro 
465                 470                 475                 480 


Gln Val Leu Ala Gln Pro Ser Thr Ser Arg Lys Arg Pro Arg Glu Gly 
                485                 490                 495     


Glu Ala Glu Gly Ala Glu Thr Thr Lys Arg Pro Ala Val Cys Ala Ala 
            500                 505                 510         


Val Leu 
        


<210>  2753
<211>  543
<212>  PRT
<213>  Homo Sapiens

<400>  2753

Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Thr Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Thr Ser Thr Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Thr Leu Ser Ser Leu Glu 
    50                  55                  60                  


Thr Val Ser Thr Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro 
65                  70                  75                  80  


Glu Asp Gln Glu Pro Glu Glu Pro Thr Pro Ala Pro Trp Ala Arg Leu 
                85                  90                  95      


Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Glu Cys Val Asn Asp Asn 
            100                 105                 110         


Tyr Trp Phe Gly Arg Asp Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro 
        115                 120                 125             


Leu Leu Lys Arg Thr Asp Lys Tyr Arg Thr Tyr Ser Lys Lys His Phe 
    130                 135                 140                 


Arg Ile Phe Arg Glu Val Gly Pro Lys Asn Ser Tyr Ile Ala Tyr Ile 
145                 150                 155                 160 


Glu Asp His Ser Gly Asn Gly Thr Phe Val Asn Thr Glu Leu Val Gly 
                165                 170                 175     


Lys Gly Lys Arg Arg Pro Leu Asn Asn Asn Ser Glu Ile Ala Leu Ser 
            180                 185                 190         


Leu Ser Arg Asn Lys Val Phe Val Phe Phe Asp Leu Thr Val Asp Asp 
        195                 200                 205             


Gln Ser Val Tyr Pro Lys Ala Leu Arg Asp Glu Tyr Ile Met Ser Lys 
    210                 215                 220                 


Thr Leu Gly Ser Gly Ala Cys Gly Glu Val Lys Leu Ala Phe Glu Arg 
225                 230                 235                 240 


Lys Thr Cys Lys Lys Val Ala Ile Lys Ile Ile Ser Lys Arg Lys Phe 
                245                 250                 255     


Ala Ile Gly Ser Ala Arg Glu Ala Asp Pro Ala Leu Asn Val Glu Thr 
            260                 265                 270         


Glu Ile Glu Ile Leu Lys Lys Leu Asn His Pro Cys Ile Ile Lys Ile 
        275                 280                 285             


Lys Asn Phe Phe Asp Ala Glu Asp Tyr Tyr Ile Val Leu Glu Leu Met 
    290                 295                 300                 


Glu Gly Gly Glu Leu Phe Asp Lys Val Val Gly Asn Lys Arg Leu Lys 
305                 310                 315                 320 


Glu Ala Thr Cys Lys Leu Tyr Phe Tyr Gln Met Leu Leu Ala Val Gln 
                325                 330                 335     


Tyr Leu His Glu Asn Gly Ile Ile His Arg Asp Leu Lys Pro Glu Asn 
            340                 345                 350         


Val Leu Leu Ser Ser Gln Glu Glu Asp Cys Leu Ile Lys Ile Thr Asp 
        355                 360                 365             


Phe Gly His Ser Lys Ile Leu Gly Glu Thr Ser Leu Met Arg Thr Leu 
    370                 375                 380                 


Cys Gly Thr Pro Thr Tyr Leu Ala Pro Glu Val Leu Val Ser Val Gly 
385                 390                 395                 400 


Thr Ala Gly Tyr Asn Arg Ala Val Asp Cys Trp Ser Leu Gly Val Ile 
                405                 410                 415     


Leu Phe Ile Cys Leu Ser Gly Tyr Pro Pro Phe Ser Glu His Arg Thr 
            420                 425                 430         


Gln Val Ser Leu Lys Asp Gln Ile Thr Ser Gly Lys Tyr Asn Phe Ile 
        435                 440                 445             


Pro Glu Val Trp Ala Glu Val Ser Glu Lys Ala Leu Asp Leu Val Lys 
    450                 455                 460                 


Lys Leu Leu Val Val Asp Pro Lys Ala Arg Phe Thr Thr Glu Glu Ala 
465                 470                 475                 480 


Leu Arg His Pro Trp Leu Gln Asp Glu Asp Met Lys Arg Lys Phe Gln 
                485                 490                 495     


Asp Leu Leu Ser Glu Glu Asn Glu Ser Thr Ala Leu Pro Gln Val Leu 
            500                 505                 510         


Ala Gln Pro Ser Thr Ser Arg Lys Arg Pro Arg Glu Gly Glu Ala Glu 
        515                 520                 525             


Gly Ala Glu Thr Thr Lys Arg Pro Ala Val Cys Ala Ala Val Leu 
    530                 535                 540             


<210>  2754
<211>  289
<212>  PRT
<213>  Homo Sapiens

<400>  2754

Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Thr Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Thr Ser Thr Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Thr Leu Ser Ser Leu Glu 
    50                  55                  60                  


Thr Val Ser Thr Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro 
65                  70                  75                  80  


Glu Asp Gln Glu Pro Glu Glu Pro Thr Pro Ala Pro Trp Ala Arg Leu 
                85                  90                  95      


Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Glu Cys Val Asn Asp Asn 
            100                 105                 110         


Tyr Trp Phe Gly Arg Asp Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro 
        115                 120                 125             


Leu Leu Lys Arg Thr Asp Lys Tyr Arg Thr Tyr Ser Lys Lys His Phe 
    130                 135                 140                 


Arg Ile Phe Arg Glu Val Gly Pro Lys Asn Ser Tyr Ile Ala Tyr Ile 
145                 150                 155                 160 


Glu Asp His Ser Gly Asn Gly Thr Phe Val Asn Thr Glu Leu Val Gly 
                165                 170                 175     


Lys Gly Lys Arg Arg Pro Leu Asn Asn Asn Ser Glu Ile Ala Leu Ser 
            180                 185                 190         


Leu Ser Arg Asn Lys Val Phe Val Phe Phe Asp Leu Thr Val Asp Asp 
        195                 200                 205             


Gln Ser Val Tyr Pro Lys Ala Leu Arg Asp Glu Tyr Ile Met Ser Lys 
    210                 215                 220                 


Thr Leu Gly Ser Gly Ala Cys Gly Glu Val Lys Leu Ala Phe Glu Arg 
225                 230                 235                 240 


Lys Thr Cys Lys Lys Val Ala Ile Lys Ile Ile Ser Lys Arg Lys Phe 
                245                 250                 255     


Ala Ile Gly Ser Ala Arg Glu Ala Asp Pro Ala Leu Asn Val Glu Thr 
            260                 265                 270         


Glu Ile Glu Ile Leu Lys Lys Leu Asn His Asp Gly Arg Gly Arg Ala 
        275                 280                 285             


Val 
    


<210>  2755
<211>  543
<212>  PRT
<213>  Homo Sapiens

<400>  2755

Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Thr Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Thr Ser Thr Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Thr Leu Ser Ser Leu Glu 
    50                  55                  60                  


Thr Val Ser Thr Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro 
65                  70                  75                  80  


Glu Asp Gln Glu Pro Glu Glu Pro Thr Pro Ala Pro Trp Ala Arg Leu 
                85                  90                  95      


Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Glu Cys Val Asn Asp Asn 
            100                 105                 110         


Tyr Trp Phe Gly Arg Asp Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro 
        115                 120                 125             


Leu Leu Lys Arg Thr Asp Lys Tyr Arg Thr Tyr Ser Lys Lys His Phe 
    130                 135                 140                 


Arg Ile Phe Arg Glu Val Gly Pro Lys Asn Ser Tyr Ile Ala Tyr Ile 
145                 150                 155                 160 


Glu Asp His Ser Gly Asn Gly Thr Phe Val Asn Thr Glu Leu Val Gly 
                165                 170                 175     


Lys Gly Lys Arg Arg Pro Leu Asn Asn Asn Ser Glu Ile Ala Leu Ser 
            180                 185                 190         


Leu Ser Arg Asn Lys Val Phe Val Phe Phe Asp Leu Thr Val Asp Asp 
        195                 200                 205             


Gln Ser Val Tyr Pro Lys Ala Leu Arg Asp Glu Tyr Ile Met Ser Lys 
    210                 215                 220                 


Thr Leu Gly Ser Gly Ala Cys Gly Glu Val Lys Leu Ala Phe Glu Arg 
225                 230                 235                 240 


Lys Thr Cys Lys Lys Val Ala Ile Lys Ile Ile Ser Lys Arg Lys Phe 
                245                 250                 255     


Ala Ile Gly Ser Ala Arg Glu Ala Asp Pro Ala Leu Asn Val Glu Thr 
            260                 265                 270         


Glu Ile Glu Ile Leu Lys Lys Leu Asn His Pro Cys Ile Ile Lys Ile 
        275                 280                 285             


Lys Asn Phe Phe Asp Ala Glu Asp Tyr Tyr Ile Val Leu Glu Leu Met 
    290                 295                 300                 


Glu Gly Gly Glu Leu Phe Asp Lys Val Val Gly Asn Lys Arg Leu Lys 
305                 310                 315                 320 


Glu Ala Thr Cys Lys Leu Tyr Phe Tyr Gln Met Leu Leu Ala Val Gln 
                325                 330                 335     


Tyr Leu His Glu Asn Gly Ile Ile His Arg Asp Leu Lys Pro Glu Asn 
            340                 345                 350         


Val Leu Leu Ser Ser Gln Glu Glu Asp Cys Leu Ile Lys Ile Thr Asp 
        355                 360                 365             


Phe Gly His Ser Lys Ile Leu Gly Glu Thr Ser Leu Met Arg Thr Leu 
    370                 375                 380                 


Cys Gly Thr Pro Thr Tyr Leu Ala Pro Glu Val Leu Val Ser Val Gly 
385                 390                 395                 400 


Thr Ala Gly Tyr Asn Arg Ala Val Asp Cys Trp Ser Leu Gly Val Ile 
                405                 410                 415     


Leu Phe Ile Cys Leu Ser Gly Tyr Pro Pro Phe Ser Glu His Arg Thr 
            420                 425                 430         


Gln Val Ser Leu Lys Asp Gln Ile Thr Ser Gly Lys Tyr Asn Phe Ile 
        435                 440                 445             


Pro Glu Val Trp Ala Glu Val Ser Glu Lys Ala Leu Asp Leu Val Lys 
    450                 455                 460                 


Lys Leu Leu Val Val Asp Pro Lys Ala Arg Phe Thr Thr Glu Glu Ala 
465                 470                 475                 480 


Leu Arg His Pro Trp Leu Gln Asp Glu Asp Met Lys Arg Lys Phe Gln 
                485                 490                 495     


Asp Leu Leu Ser Glu Glu Asn Glu Ser Thr Ala Leu Pro Gln Val Leu 
            500                 505                 510         


Ala Gln Pro Ser Thr Ser Arg Lys Arg Pro Arg Glu Gly Glu Ala Glu 
        515                 520                 525             


Gly Ala Glu Thr Thr Lys Arg Pro Ala Val Cys Ala Ala Val Leu 
    530                 535                 540             


<210>  2756
<211>  203
<212>  PRT
<213>  Homo Sapiens

<400>  2756

Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Thr Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Thr Ser Thr Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Thr Leu Ser Ser Leu Glu 
    50                  55                  60                  


Thr Val Ser Thr Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro 
65                  70                  75                  80  


Glu Asp Gln Glu Pro Glu Glu Pro Thr Pro Ala Pro Trp Ala Arg Leu 
                85                  90                  95      


Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Glu Cys Val Asn Asp Asn 
            100                 105                 110         


Tyr Trp Phe Gly Arg Asp Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro 
        115                 120                 125             


Leu Leu Lys Arg Thr Asp Lys Tyr Arg Thr Tyr Ser Lys Lys His Phe 
    130                 135                 140                 


Arg Ile Phe Arg Glu Val Gly Pro Lys Asn Ser Tyr Ile Ala Tyr Ile 
145                 150                 155                 160 


Glu Asp His Ser Gly Asn Gly Thr Phe Val Asn Thr Glu Leu Val Gly 
                165                 170                 175     


Lys Gly Lys Arg Arg Pro Leu Asn Asn Asn Ser Glu Ile Ala Leu Ser 
            180                 185                 190         


Leu Ser Arg Asn Lys Val Val Pro Val Glu Arg 
        195                 200             


<210>  2757
<211>  295
<212>  PRT
<213>  Homo Sapiens

<400>  2757

Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Thr Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Thr Ser Thr Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Thr Leu Ser Ser Leu Glu 
    50                  55                  60                  


Thr Val Ser Thr Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro 
65                  70                  75                  80  


Glu Asp Gln Glu Pro Glu Glu Pro Thr Pro Ala Pro Trp Ala Arg Leu 
                85                  90                  95      


Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Glu Thr Glu Ser Gly His 
            100                 105                 110         


Val Thr Gln Ser Asp Leu Glu Leu Leu Leu Ser Ser Asp Pro Pro Ala 
        115                 120                 125             


Ser Ala Ser Gln Ser Ala Gly Ile Arg Glu Cys Val Asn Asp Asn Tyr 
    130                 135                 140                 


Trp Phe Gly Arg Asp Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro Leu 
145                 150                 155                 160 


Leu Lys Arg Thr Asp Lys Tyr Arg Thr Tyr Ser Lys Lys His Phe Arg 
                165                 170                 175     


Ile Phe Arg Glu Val Gly Pro Lys Asn Ser Tyr Ile Ala Tyr Ile Glu 
            180                 185                 190         


Asp His Ser Gly Asn Gly Thr Phe Val Asn Thr Glu Leu Val Gly Lys 
        195                 200                 205             


Gly Lys Arg Arg Pro Leu Asn Asn Asn Ser Glu Ile Ala Leu Ser Leu 
    210                 215                 220                 


Ser Arg Asn Lys Val Phe Val Phe Phe Asp Leu Thr Val Asp Asp Gln 
225                 230                 235                 240 


Ser Val Tyr Pro Lys Ala Leu Arg Asp Glu Tyr Ile Met Ser Lys Thr 
                245                 250                 255     


Leu Gly Ser Gly Ala Cys Gly Glu Val Lys Leu Ala Phe Glu Arg Lys 
            260                 265                 270         


Thr Cys Lys Lys Val Ala Ile Lys Ile Ile Ser Lys Arg Lys Phe Ala 
        275                 280                 285             


Ile Gly Ser Ala Arg Glu Ala 
    290                 295 


<210>  2758
<211>  586
<212>  PRT
<213>  Homo Sapiens

<400>  2758

Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Thr Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Thr Ser Thr Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Thr Leu Ser Ser Leu Glu 
    50                  55                  60                  


Thr Val Ser Thr Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro 
65                  70                  75                  80  


Glu Asp Gln Glu Pro Glu Glu Pro Thr Pro Ala Pro Trp Ala Arg Leu 
                85                  90                  95      


Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Glu Thr Glu Ser Gly His 
            100                 105                 110         


Val Thr Gln Ser Asp Leu Glu Leu Leu Leu Ser Ser Asp Pro Pro Ala 
        115                 120                 125             


Ser Ala Ser Gln Ser Ala Gly Ile Arg Gly Val Arg His His Pro Arg 
    130                 135                 140                 


Pro Val Cys Ser Leu Lys Cys Val Asn Asp Asn Tyr Trp Phe Gly Arg 
145                 150                 155                 160 


Asp Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro Leu Leu Lys Arg Thr 
                165                 170                 175     


Asp Lys Tyr Arg Thr Tyr Ser Lys Lys His Phe Arg Ile Phe Arg Glu 
            180                 185                 190         


Val Gly Pro Lys Asn Ser Tyr Ile Ala Tyr Ile Glu Asp His Ser Gly 
        195                 200                 205             


Asn Gly Thr Phe Val Asn Thr Glu Leu Val Gly Lys Gly Lys Arg Arg 
    210                 215                 220                 


Pro Leu Asn Asn Asn Ser Glu Ile Ala Leu Ser Leu Ser Arg Asn Lys 
225                 230                 235                 240 


Val Phe Val Phe Phe Asp Leu Thr Val Asp Asp Gln Ser Val Tyr Pro 
                245                 250                 255     


Lys Ala Leu Arg Asp Glu Tyr Ile Met Ser Lys Thr Leu Gly Ser Gly 
            260                 265                 270         


Ala Cys Gly Glu Val Lys Leu Ala Phe Glu Arg Lys Thr Cys Lys Lys 
        275                 280                 285             


Val Ala Ile Lys Ile Ile Ser Lys Arg Lys Phe Ala Ile Gly Ser Ala 
    290                 295                 300                 


Arg Glu Ala Asp Pro Ala Leu Asn Val Glu Thr Glu Ile Glu Ile Leu 
305                 310                 315                 320 


Lys Lys Leu Asn His Pro Cys Ile Ile Lys Ile Lys Asn Phe Phe Asp 
                325                 330                 335     


Ala Glu Asp Tyr Tyr Ile Val Leu Glu Leu Met Glu Gly Gly Glu Leu 
            340                 345                 350         


Phe Asp Lys Val Val Gly Asn Lys Arg Leu Lys Glu Ala Thr Cys Lys 
        355                 360                 365             


Leu Tyr Phe Tyr Gln Met Leu Leu Ala Val Gln Tyr Leu His Glu Asn 
    370                 375                 380                 


Gly Ile Ile His Arg Asp Leu Lys Pro Glu Asn Val Leu Leu Ser Ser 
385                 390                 395                 400 


Gln Glu Glu Asp Cys Leu Ile Lys Ile Thr Asp Phe Gly His Ser Lys 
                405                 410                 415     


Ile Leu Gly Glu Thr Ser Leu Met Arg Thr Leu Cys Gly Thr Pro Thr 
            420                 425                 430         


Tyr Leu Ala Pro Glu Val Leu Val Ser Val Gly Thr Ala Gly Tyr Asn 
        435                 440                 445             


Arg Ala Val Asp Cys Trp Ser Leu Gly Val Ile Leu Phe Ile Cys Leu 
    450                 455                 460                 


Ser Gly Tyr Pro Pro Phe Ser Glu His Arg Thr Gln Val Ser Leu Lys 
465                 470                 475                 480 


Asp Gln Ile Thr Ser Gly Lys Tyr Asn Phe Ile Pro Glu Val Trp Ala 
                485                 490                 495     


Glu Val Ser Glu Lys Ala Leu Asp Leu Val Lys Lys Leu Leu Val Val 
            500                 505                 510         


Asp Pro Lys Ala Arg Phe Thr Thr Glu Glu Ala Leu Arg His Pro Trp 
        515                 520                 525             


Leu Gln Asp Glu Asp Met Lys Arg Lys Phe Gln Asp Leu Leu Ser Glu 
    530                 535                 540                 


Glu Asn Glu Ser Thr Ala Leu Pro Gln Val Leu Ala Gln Pro Ser Thr 
545                 550                 555                 560 


Ser Arg Lys Arg Pro Arg Glu Gly Glu Ala Glu Gly Ala Glu Thr Thr 
                565                 570                 575     


Lys Arg Pro Ala Val Cys Ala Ala Val Leu 
            580                 585     


<210>  2759
<211>  452
<212>  PRT
<213>  Homo Sapiens

<400>  2759

Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser 
1               5                   10                  15      


Ala Cys Ser Gln Pro His Gly Ser Val Thr Gln Ser Gln Gly Ser Ser 
            20                  25                  30          


Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Thr Ser Thr Met Pro Asn 
        35                  40                  45              


Ser Ser Gln Ser Ser His Ser Ser Ser Gly Thr Leu Ser Ser Leu Glu 
    50                  55                  60                  


Thr Val Ser Thr Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro 
65                  70                  75                  80  


Glu Asp Gln Glu Pro Glu Glu Pro Thr Pro Ala Pro Trp Ala Arg Leu 
                85                  90                  95      


Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Val Phe Val Phe Phe Asp 
            100                 105                 110         


Leu Thr Val Asp Asp Gln Ser Val Tyr Pro Lys Ala Leu Arg Asp Glu 
        115                 120                 125             


Tyr Ile Met Ser Lys Thr Leu Gly Ser Gly Ala Cys Gly Glu Val Lys 
    130                 135                 140                 


Leu Ala Phe Glu Arg Lys Thr Cys Lys Lys Val Ala Ile Lys Ile Ile 
145                 150                 155                 160 


Ser Lys Arg Lys Phe Ala Ile Gly Ser Ala Arg Glu Ala Asp Pro Ala 
                165                 170                 175     


Leu Asn Val Glu Thr Glu Ile Glu Ile Leu Lys Lys Leu Asn His Pro 
            180                 185                 190         


Cys Ile Ile Lys Ile Lys Asn Phe Phe Asp Ala Glu Asp Tyr Tyr Ile 
        195                 200                 205             


Val Leu Glu Leu Met Glu Gly Gly Glu Leu Phe Asp Lys Val Val Gly 
    210                 215                 220                 


Asn Lys Arg Leu Lys Glu Ala Thr Cys Lys Leu Tyr Phe Tyr Gln Met 
225                 230                 235                 240 


Leu Leu Ala Val Gln Tyr Leu His Glu Asn Gly Ile Ile His Arg Asp 
                245                 250                 255     


Leu Lys Pro Glu Asn Val Leu Leu Ser Ser Gln Glu Glu Asp Cys Leu 
            260                 265                 270         


Ile Lys Ile Thr Asp Phe Gly His Ser Lys Ile Leu Gly Glu Thr Ser 
        275                 280                 285             


Leu Met Arg Thr Leu Cys Gly Thr Pro Thr Tyr Leu Ala Pro Glu Val 
    290                 295                 300                 


Leu Val Ser Val Gly Thr Ala Gly Tyr Asn Arg Ala Val Asp Cys Trp 
305                 310                 315                 320 


Ser Leu Gly Val Ile Leu Phe Ile Cys Leu Ser Gly Tyr Pro Pro Phe 
                325                 330                 335     


Ser Glu His Arg Thr Gln Val Ser Leu Lys Asp Gln Ile Thr Ser Gly 
            340                 345                 350         


Lys Tyr Asn Phe Ile Pro Glu Val Trp Ala Glu Val Ser Glu Lys Ala 
        355                 360                 365             


Leu Asp Leu Val Lys Lys Leu Leu Val Val Asp Pro Lys Ala Arg Phe 
    370                 375                 380                 


Thr Thr Glu Glu Ala Leu Arg His Pro Trp Leu Gln Asp Glu Asp Met 
385                 390                 395                 400 


Lys Arg Lys Phe Gln Asp Leu Leu Ser Glu Glu Asn Glu Ser Thr Ala 
                405                 410                 415     


Leu Pro Gln Val Leu Ala Gln Pro Ser Thr Ser Arg Lys Arg Pro Arg 
            420                 425                 430         


Glu Gly Glu Ala Glu Gly Ala Glu Thr Thr Lys Arg Pro Ala Val Cys 
        435                 440                 445             


Ala Ala Val Leu 
    450         


<210>  2760
<211>  45
<212>  PRT
<213>  Homo Sapiens

<400>  2760

Ser Ser Asp Pro Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Arg Gly 
1               5                   10                  15      


Val Arg His His Pro Arg Pro Val Cys Ser Leu Ile Glu Thr Gly Phe 
            20                  25                  30          


His Arg Val Ser Gln Asp Gly Leu His Leu Leu Thr Ser 
        35                  40                  45  


<210>  2761
<211>  276
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2761

Xaa Ile Gly Ser Ala Arg Glu Ala Asp Pro Ala Leu Asn Val Glu Thr 
1               5                   10                  15      


Glu Ile Glu Ile Leu Lys Lys Leu Asn His Pro Cys Ile Ile Lys Ile 
            20                  25                  30          


Lys Asn Phe Phe Asp Ala Glu Asp Tyr Tyr Ile Val Leu Glu Leu Met 
        35                  40                  45              


Glu Gly Gly Glu Leu Phe Asp Lys Val Val Gly Asn Lys Arg Leu Lys 
    50                  55                  60                  


Glu Ala Thr Cys Lys Leu Tyr Phe Tyr Gln Met Leu Leu Ala Val Gln 
65                  70                  75                  80  


Tyr Leu His Glu Asn Gly Ile Ile His Arg Asp Leu Lys Pro Glu Asn 
                85                  90                  95      


Val Leu Leu Ser Ser Gln Glu Glu Asp Cys Leu Ile Lys Ile Thr Asp 
            100                 105                 110         


Phe Gly His Ser Lys Ile Leu Gly Glu Thr Ser Leu Met Arg Thr Leu 
        115                 120                 125             


Cys Gly Thr Pro Thr Tyr Leu Ala Pro Glu Val Leu Val Ser Val Gly 
    130                 135                 140                 


Thr Ala Gly Tyr Asn Arg Ala Val Asp Cys Trp Ser Leu Gly Val Ile 
145                 150                 155                 160 


Leu Phe Ile Trp Thr Gln Val Ser Leu Lys Asp Gln Ile Thr Ser Gly 
                165                 170                 175     


Lys Tyr Asn Phe Ile Pro Glu Val Trp Ala Glu Val Ser Glu Lys Ala 
            180                 185                 190         


Leu Asp Leu Val Lys Lys Leu Leu Val Val Asp Pro Lys Ala Arg Phe 
        195                 200                 205             


Thr Thr Glu Glu Ala Leu Arg His Pro Trp Leu Gln Asp Glu Asp Met 
    210                 215                 220                 


Lys Arg Lys Phe Gln Asp Leu Leu Ser Glu Glu Asn Glu Ser Thr Ala 
225                 230                 235                 240 


Leu Pro Gln Val Leu Ala Gln Pro Ser Thr Ser Arg Lys Arg Pro Arg 
                245                 250                 255     


Glu Gly Glu Ala Glu Gly Ala Glu Thr Thr Lys Arg Pro Ala Val Cys 
            260                 265                 270         


Ala Ala Val Leu 
        275     


<210>  2762
<211>  144
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2762

Xaa Ile Ile Ser Lys Arg Lys Phe Ala Ile Gly Ser Ala Arg Glu Ala 
1               5                   10                  15      


Asp Pro Ala Leu Asn Val Glu Thr Glu Ile Glu Ile Leu Lys Lys Leu 
            20                  25                  30          


Asn His Pro Cys Ile Ile Lys Ile Lys Asn Phe Phe Asp Ala Glu Asp 
        35                  40                  45              


Tyr Tyr Ile Val Leu Glu Leu Met Glu Gly Gly Glu Leu Phe Asp Lys 
    50                  55                  60                  


Val Val Gly Asn Lys Arg Leu Lys Glu Ala Thr Cys Lys Leu Tyr Phe 
65                  70                  75                  80  


Tyr Gln Met Leu Leu Ala Val Gln Asp Glu Asp Met Lys Arg Lys Phe 
                85                  90                  95      


Gln Asp Leu Leu Ser Glu Glu Asn Glu Ser Thr Ala Leu Pro Gln Val 
            100                 105                 110         


Leu Ala Gln Pro Ser Thr Ser Arg Lys Arg Pro Arg Glu Gly Glu Ala 
        115                 120                 125             


Glu Gly Ala Glu Thr Thr Lys Arg Pro Ala Val Cys Ala Ala Val Leu 
    130                 135                 140                 


<210>  2763
<211>  38
<212>  PRT
<213>  Homo Sapiens

<400>  2763

Met Arg Ser Ala Ala Val Leu Ala Leu Leu Leu Cys Ala Gly Gln Val 
1               5                   10                  15      


Thr Ala Leu Pro Val Asn Ser Pro Met Asn Lys Gly Asp Thr Glu Met 
            20                  25                  30          


Asn Gly Ser Phe Pro Phe 
        35              


<210>  2764
<211>  457
<212>  PRT
<213>  Homo Sapiens

<400>  2764

Met Arg Ser Ala Ala Val Leu Ala Leu Leu Leu Cys Ala Gly Gln Val 
1               5                   10                  15      


Thr Ala Leu Pro Val Asn Ser Pro Met Asn Lys Gly Asp Thr Glu Val 
            20                  25                  30          


Met Lys Cys Ile Val Glu Val Ile Ser Asp Thr Leu Ser Lys Pro Ser 
        35                  40                  45              


Pro Met Pro Val Ser Gln Glu Cys Phe Glu Thr Leu Arg Gly Asp Glu 
    50                  55                  60                  


Arg Ile Leu Ser Ile Leu Arg His Gln Asn Leu Leu Lys Glu Leu Gln 
65                  70                  75                  80  


Asp Leu Ala Leu Gln Gly Ala Lys Glu Arg Ala His Gln Gln Lys Lys 
                85                  90                  95      


His Ser Gly Phe Glu Asp Glu Leu Ser Glu Val Leu Glu Asn Gln Ser 
            100                 105                 110         


Ser Gln Ala Glu Leu Lys Glu Ala Val Glu Glu Pro Ser Ser Lys Asp 
        115                 120                 125             


Val Met Glu Lys Arg Glu Asp Ser Lys Glu Ala Glu Lys Ser Gly Glu 
    130                 135                 140                 


Ala Thr Asp Gly Ala Arg Pro Gln Ala Leu Pro Glu Pro Met Gln Glu 
145                 150                 155                 160 


Ser Lys Ala Glu Gly Asn Asn Gln Ala Pro Gly Glu Glu Glu Glu Glu 
                165                 170                 175     


Glu Glu Glu Ala Thr Asn Thr His Pro Pro Ala Ser Leu Pro Ser Gln 
            180                 185                 190         


Lys Tyr Pro Gly Pro Gln Ala Glu Gly Asp Ser Glu Gly Leu Ser Gln 
        195                 200                 205             


Gly Leu Val Asp Arg Glu Lys Gly Leu Ser Ala Glu Pro Gly Trp Gln 
    210                 215                 220                 


Ala Lys Arg Glu Glu Glu Glu Glu Glu Glu Glu Glu Ala Glu Ala Gly 
225                 230                 235                 240 


Glu Glu Ala Val Pro Glu Glu Glu Gly Pro Thr Val Val Leu Asn Pro 
                245                 250                 255     


His Pro Ser Leu Gly Tyr Lys Glu Ile Arg Lys Gly Glu Ser Arg Ser 
            260                 265                 270         


Glu Ala Leu Ala Val Asp Gly Ala Gly Lys Pro Gly Ala Glu Glu Ala 
        275                 280                 285             


Gln Asp Pro Glu Gly Lys Gly Glu Gln Glu His Ser Gln Gln Lys Glu 
    290                 295                 300                 


Glu Glu Glu Glu Met Ala Val Val Pro Gln Gly Leu Phe Arg Gly Gly 
305                 310                 315                 320 


Lys Ser Gly Glu Leu Glu Gln Glu Glu Glu Arg Leu Ser Lys Glu Trp 
                325                 330                 335     


Glu Asp Ser Lys Arg Trp Ser Lys Met Asp Gln Leu Ala Lys Glu Leu 
            340                 345                 350         


Thr Ala Glu Lys Arg Leu Glu Gly Gln Glu Glu Glu Glu Asp Asn Arg 
        355                 360                 365             


Asp Ser Ser Met Lys Leu Ser Phe Arg Ala Arg Ala Tyr Gly Phe Arg 
    370                 375                 380                 


Gly Pro Gly Pro Gln Leu Arg Arg Gly Trp Arg Pro Ser Ser Arg Glu 
385                 390                 395                 400 


Asp Ser Leu Glu Ala Gly Leu Pro Leu Gln Val Arg Gly Tyr Pro Glu 
                405                 410                 415     


Glu Lys Lys Glu Glu Glu Gly Ser Ala Asn Arg Arg Pro Glu Asp Gln 
            420                 425                 430         


Glu Leu Glu Ser Leu Ser Ala Ile Glu Ala Glu Leu Glu Lys Val Ala 
        435                 440                 445             


His Gln Leu Gln Ala Leu Arg Arg Gly 
    450                 455         


<210>  2765
<211>  306
<212>  PRT
<213>  Homo Sapiens

<400>  2765

Met Arg Ser Ala Ala Val Leu Ala Leu Leu Leu Cys Ala Gly Gln Val 
1               5                   10                  15      


Thr Ala Leu Pro Val Asn Ser Pro Met Asn Lys Gly Asp Thr Glu Val 
            20                  25                  30          


Met Lys Cys Ile Val Glu Val Ile Ser Asp Thr Leu Ser Lys Pro Ser 
        35                  40                  45              


Pro Met Pro Val Ser Gln Glu Cys Phe Glu Thr Leu Arg Gly Asp Glu 
    50                  55                  60                  


Arg Ile Leu Ser Ile Leu Arg His Gln Asn Leu Leu Lys Glu Leu Gln 
65                  70                  75                  80  


Asp Leu Ala Leu Gln Gly Ala Lys Glu Arg Ala His Gln Gln Lys Lys 
                85                  90                  95      


His Ser Gly Phe Glu Asp Glu Leu Ser Glu Val Leu Glu Asn Gln Ser 
            100                 105                 110         


Ser Gln Ala Glu Leu Lys Gly Arg Ser Glu Ala Leu Ala Val Asp Gly 
        115                 120                 125             


Ala Gly Lys Pro Gly Ala Glu Glu Ala Gln Asp Pro Glu Gly Lys Gly 
    130                 135                 140                 


Glu Gln Glu His Ser Gln Gln Lys Glu Glu Glu Glu Glu Met Ala Val 
145                 150                 155                 160 


Val Pro Gln Gly Leu Phe Arg Gly Gly Lys Ser Gly Glu Leu Glu Gln 
                165                 170                 175     


Glu Glu Glu Arg Leu Ser Lys Glu Trp Glu Asp Ser Lys Arg Trp Ser 
            180                 185                 190         


Lys Met Asp Gln Leu Ala Lys Glu Leu Thr Ala Glu Lys Arg Leu Glu 
        195                 200                 205             


Gly Gln Glu Glu Glu Glu Asp Asn Arg Asp Ser Ser Met Lys Leu Ser 
    210                 215                 220                 


Phe Arg Ala Arg Ala Tyr Gly Phe Arg Gly Pro Gly Pro Gln Leu Arg 
225                 230                 235                 240 


Arg Gly Trp Arg Pro Ser Ser Arg Glu Asp Ser Leu Glu Ala Gly Leu 
                245                 250                 255     


Pro Leu Gln Val Arg Gly Tyr Pro Glu Glu Lys Lys Glu Glu Glu Gly 
            260                 265                 270         


Ser Ala Asn Arg Arg Pro Glu Asp Gln Glu Leu Glu Ser Leu Ser Ala 
        275                 280                 285             


Ile Glu Ala Glu Leu Glu Lys Val Ala His Gln Leu Gln Ala Leu Arg 
    290                 295                 300                 


Arg Gly 
305     


<210>  2766
<211>  289
<212>  PRT
<213>  Homo Sapiens

<400>  2766

Met Pro Val Asp Asn Arg Asn His Asn Glu Gly Met Val Thr Arg Cys 
1               5                   10                  15      


Ile Ile Glu Val Leu Ser Asn Ala Leu Ser Lys Ser Ser Ala Pro Pro 
            20                  25                  30          


Ile Thr Pro Glu Cys Arg Gln Val Leu Lys Thr Ser Arg Lys Asp Val 
        35                  40                  45              


Lys Asp Lys Glu Thr Thr Glu Asn Glu Asn Thr Lys Phe Glu Val Arg 
    50                  55                  60                  


Leu Leu Arg Asp Pro Ala Asp Ala Ser Glu Ala His Glu Ser Ser Ser 
65                  70                  75                  80  


Arg Gly Glu Ala Gly Ala Pro Gly Glu Glu Asp Ile Gln Gly Pro Thr 
                85                  90                  95      


Lys Ala Asp Thr Glu Lys Trp Ala Glu Gly Gly Gly His Ser Arg Glu 
            100                 105                 110         


Arg Ala Asp Glu Pro Gln Trp Ser Leu Tyr Pro Ser Asp Ser Gln Val 
        115                 120                 125             


Ser Glu Glu Val Lys Thr Arg His Ser Glu Lys Ser Gln Arg Glu Asp 
    130                 135                 140                 


Glu Glu Glu Glu Glu Gly Glu Asn Tyr Gln Lys Gly Glu Arg Gly Glu 
145                 150                 155                 160 


Asp Ser Ser Glu Glu Lys His Leu Glu Glu Pro Gly Glu Thr Gln Asn 
                165                 170                 175     


Ala Phe Leu Asn Glu Arg Lys Gln Ala Ser Ala Ile Lys Lys Glu Glu 
            180                 185                 190         


Leu Val Ala Arg Ser Glu Thr His Ala Ala Gly His Ser Gln Glu Lys 
        195                 200                 205             


Thr His Ser Arg Glu Lys Ser Ser Gln Glu Ser Gly Glu Glu Thr Gly 
    210                 215                 220                 


Ser Gln Glu Asn His Pro Gln Glu Ser Lys Gly Gln Pro Arg Ser Gln 
225                 230                 235                 240 


Glu Glu Ser Glu Glu Gly Glu Glu Asp Ala Thr Ser Glu Val Asp Lys 
                245                 250                 255     


Arg Arg Thr Arg Pro Arg His His His Gly Arg Ser Arg Pro Asp Arg 
            260                 265                 270         


Ser Ser Gln Gly Gly Ser Leu Pro Ser Glu Glu Lys Gly His Pro Gln 
        275                 280                 285             


Glu 
    


<210>  2767
<211>  677
<212>  PRT
<213>  Homo Sapiens

<400>  2767

Met Gln Pro Thr Leu Leu Leu Ser Leu Leu Gly Ala Val Gly Leu Ala 
1               5                   10                  15      


Ala Val Asn Ser Met Pro Val Asp Asn Arg Asn His Asn Glu Gly Met 
            20                  25                  30          


Val Thr Arg Cys Ile Ile Glu Val Leu Ser Asn Ala Leu Ser Lys Ser 
        35                  40                  45              


Ser Ala Pro Pro Ile Thr Pro Glu Cys Arg Gln Val Leu Lys Thr Ser 
    50                  55                  60                  


Arg Lys Asp Val Lys Asp Lys Glu Thr Thr Glu Asn Glu Asn Thr Lys 
65                  70                  75                  80  


Phe Glu Val Arg Leu Leu Arg Asp Pro Ala Asp Ala Ser Glu Ala His 
                85                  90                  95      


Glu Ser Ser Ser Arg Gly Glu Ala Gly Ala Pro Gly Glu Glu Asp Ile 
            100                 105                 110         


Gln Gly Pro Thr Lys Ala Asp Thr Glu Lys Trp Ala Glu Gly Gly Gly 
        115                 120                 125             


His Ser Arg Glu Arg Ala Asp Glu Pro Gln Trp Ser Leu Tyr Pro Ser 
    130                 135                 140                 


Asp Ser Gln Val Ser Glu Glu Val Lys Thr Arg His Ser Glu Lys Ser 
145                 150                 155                 160 


Gln Arg Glu Asp Glu Glu Glu Glu Glu Gly Glu Asn Tyr Gln Lys Gly 
                165                 170                 175     


Glu Arg Gly Glu Asp Ser Ser Glu Glu Lys His Leu Glu Glu Pro Gly 
            180                 185                 190         


Glu Thr Gln Asn Ala Phe Leu Asn Glu Arg Lys Gln Ala Ser Ala Ile 
        195                 200                 205             


Lys Lys Glu Glu Leu Val Ala Arg Ser Glu Thr His Ala Ala Gly His 
    210                 215                 220                 


Ser Gln Glu Lys Thr His Ser Arg Glu Lys Ser Ser Gln Glu Ser Gly 
225                 230                 235                 240 


Glu Glu Thr Gly Ser Gln Glu Asn His Pro Gln Glu Ser Lys Gly Gln 
                245                 250                 255     


Pro Arg Ser Gln Glu Glu Ser Glu Glu Gly Glu Glu Asp Ala Thr Ser 
            260                 265                 270         


Glu Val Asp Lys Arg Arg Thr Arg Pro Arg His His His Gly Arg Ser 
        275                 280                 285             


Arg Pro Asp Arg Ser Ser Gln Gly Gly Ser Leu Pro Ser Glu Glu Lys 
    290                 295                 300                 


Gly His Pro Gln Glu Glu Ser Glu Glu Ser Asn Val Ser Met Ala Ser 
305                 310                 315                 320 


Leu Gly Glu Lys Arg Asp His His Ser Thr His Tyr Arg Ala Ser Glu 
                325                 330                 335     


Glu Glu Pro Glu Tyr Gly Glu Glu Ile Lys Gly Tyr Pro Gly Val Gln 
            340                 345                 350         


Ala Pro Glu Asp Leu Glu Trp Glu Arg Tyr Arg Gly Arg Gly Ser Glu 
        355                 360                 365             


Glu Tyr Arg Ala Pro Arg Pro Gln Ser Glu Glu Ser Trp Asp Glu Glu 
    370                 375                 380                 


Asp Lys Arg Asn Tyr Pro Ser Leu Glu Leu Asp Lys Met Ala His Gly 
385                 390                 395                 400 


Tyr Gly Glu Glu Ser Glu Glu Glu Arg Gly Leu Glu Pro Gly Lys Gly 
                405                 410                 415     


Arg His His Arg Gly Arg Gly Gly Glu Pro Arg Ala Tyr Phe Met Ser 
            420                 425                 430         


Asp Thr Arg Glu Glu Lys Arg Phe Leu Gly Glu Gly His His Arg Val 
        435                 440                 445             


Gln Glu Asn Gln Met Asp Lys Ala Arg Arg His Pro Gln Gly Ala Trp 
    450                 455                 460                 


Lys Glu Leu Asp Arg Asn Tyr Leu Asn Tyr Gly Glu Glu Gly Ala Pro 
465                 470                 475                 480 


Gly Lys Trp Gln Gln Gln Gly Asp Leu Gln Asp Thr Lys Glu Asn Arg 
                485                 490                 495     


Glu Glu Ala Arg Phe Gln Asp Lys Gln Tyr Ser Ser His His Thr Ala 
            500                 505                 510         


Glu Lys Arg Lys Arg Leu Gly Glu Leu Phe Asn Pro Tyr Tyr Asp Pro 
        515                 520                 525             


Leu Gln Trp Lys Ser Ser His Phe Glu Arg Arg Asp Asn Met Asn Asp 
    530                 535                 540                 


Asn Phe Leu Glu Gly Glu Glu Glu Asn Glu Leu Thr Leu Asn Glu Lys 
545                 550                 555                 560 


Asn Phe Phe Pro Glu Tyr Asn Tyr Asp Trp Trp Glu Lys Lys Pro Phe 
                565                 570                 575     


Ser Glu Asp Val Asn Trp Gly Tyr Glu Lys Arg Asn Leu Ala Arg Val 
            580                 585                 590         


Pro Lys Leu Asp Leu Lys Arg Gln Tyr Asp Arg Val Ala Gln Leu Asp 
        595                 600                 605             


Gln Leu Leu His Tyr Arg Lys Lys Ser Ala Glu Phe Pro Asp Phe Tyr 
    610                 615                 620                 


Asp Ser Glu Glu Pro Val Ser Thr His Gln Glu Ala Glu Asn Glu Lys 
625                 630                 635                 640 


Asp Arg Ala Asp Gln Thr Val Leu Thr Glu Asp Glu Lys Lys Glu Leu 
                645                 650                 655     


Glu Asn Leu Ala Ala Met Asp Leu Glu Leu Gln Lys Ile Ala Glu Lys 
            660                 665                 670         


Phe Ser Gln Arg Gly 
        675         


<210>  2768
<211>  383
<212>  PRT
<213>  Homo Sapiens

<400>  2768

Met Gly Val Lys Ala Ser Gln Thr Gly Phe Val Val Leu Val Leu Leu 
1               5                   10                  15      


Gln Cys Cys Ser Ala Tyr Lys Leu Val Cys Tyr Tyr Thr Ser Trp Ser 
            20                  25                  30          


Gln Tyr Arg Glu Gly Asp Gly Ser Cys Phe Pro Asp Ala Leu Asp Arg 
        35                  40                  45              


Phe Leu Cys Thr His Ile Ile Tyr Ser Phe Ala Asn Ile Ser Asn Asp 
    50                  55                  60                  


His Ile Asp Thr Trp Glu Trp Asn Asp Val Thr Leu Tyr Gly Met Leu 
65                  70                  75                  80  


Asn Thr Leu Lys Asn Arg Asn Pro Asn Leu Lys Thr Leu Leu Ser Val 
                85                  90                  95      


Gly Gly Trp Asn Phe Gly Ser Gln Arg Phe Ser Lys Ile Ala Ser Asn 
            100                 105                 110         


Thr Gln Ser Arg Arg Thr Phe Ile Lys Ser Val Pro Pro Phe Leu Arg 
        115                 120                 125             


Thr His Gly Phe Asp Gly Leu Asp Leu Ala Trp Leu Tyr Pro Gly Arg 
    130                 135                 140                 


Arg Asp Lys Gln His Phe Thr Thr Leu Ile Lys Glu Met Lys Ala Glu 
145                 150                 155                 160 


Phe Ile Lys Glu Ala Gln Pro Gly Lys Lys Gln Leu Leu Leu Ser Ala 
                165                 170                 175     


Ala Leu Ser Ala Gly Lys Val Thr Ile Asp Ser Ser Tyr Asp Ile Ala 
            180                 185                 190         


Lys Ile Ser Gln His Leu Asp Phe Ile Ser Ile Met Thr Tyr Asp Phe 
        195                 200                 205             


His Gly Ala Trp Arg Gly Thr Thr Gly His His Ser Pro Leu Phe Arg 
    210                 215                 220                 


Gly Gln Glu Asp Ala Ser Pro Asp Arg Phe Ser Asn Thr Asp Tyr Ala 
225                 230                 235                 240 


Val Gly Tyr Met Leu Arg Leu Gly Ala Pro Ala Ser Lys Leu Val Met 
                245                 250                 255     


Gly Ile Pro Thr Phe Gly Arg Ser Phe Thr Leu Ala Ser Ser Glu Thr 
            260                 265                 270         


Gly Val Gly Ala Pro Ile Ser Gly Pro Gly Ile Pro Gly Arg Phe Thr 
        275                 280                 285             


Lys Glu Ala Gly Thr Leu Ala Tyr Tyr Glu Ile Cys Asp Phe Leu Arg 
    290                 295                 300                 


Gly Ala Thr Val His Arg Ile Leu Gly Gln Gln Val Pro Tyr Ala Thr 
305                 310                 315                 320 


Lys Gly Asn Gln Trp Val Gly Tyr Asp Asp Gln Glu Ser Val Lys Ser 
                325                 330                 335     


Lys Val Gln Tyr Leu Lys Asp Arg Gln Leu Ala Gly Ala Met Val Trp 
            340                 345                 350         


Ala Leu Asp Leu Asp Asp Phe Gln Gly Ser Phe Cys Gly Gln Asp Leu 
        355                 360                 365             


Arg Phe Pro Leu Thr Asn Ala Ile Lys Asp Ala Leu Ala Ala Thr 
    370                 375                 380             


<210>  2769
<211>  152
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2769

Xaa Leu Leu Leu Ser Ala Ala Leu Ser Ala Gly Lys Val Thr Ile Asp 
1               5                   10                  15      


Ser Ser Tyr Asp Ile Ala Lys Ile Ser Gln His Leu Asp Phe Ile Ser 
            20                  25                  30          


Ile Met Thr Tyr Asp Phe His Gly Ala Trp Arg Gly Thr Thr Gly His 
        35                  40                  45              


His Ser Pro Leu Phe Arg Gly Gln Glu Asp Ala Ser Pro Asp Arg Phe 
    50                  55                  60                  


Ser Asn Thr Ile Cys Asp Phe Leu Arg Gly Ala Thr Val His Arg Ile 
65                  70                  75                  80  


Leu Gly Gln Gln Val Pro Tyr Ala Thr Lys Gly Asn Gln Trp Val Gly 
                85                  90                  95      


Tyr Asp Asp Gln Glu Ser Val Lys Ser Lys Val Gln Tyr Leu Lys Asp 
            100                 105                 110         


Arg Gln Leu Ala Gly Ala Met Val Trp Ala Leu Asp Leu Asp Asp Phe 
        115                 120                 125             


Gln Gly Ser Phe Cys Gly Gln Asp Leu Arg Phe Pro Leu Thr Asn Ala 
    130                 135                 140                 


Ile Lys Asp Ala Leu Ala Ala Thr 
145                 150         


<210>  2770
<211>  380
<212>  PRT
<213>  Homo Sapiens

<400>  2770

Met Gly Ala Thr Thr Met Asp Gln Lys Ser Leu Trp Ala Gly Ser Ala 
1               5                   10                  15      


Tyr Lys Leu Val Cys Tyr Phe Thr Asn Trp Ser Gln Asp Arg Gln Glu 
            20                  25                  30          


Pro Gly Lys Phe Thr Pro Glu Asn Ile Asp Pro Phe Leu Cys Ser His 
        35                  40                  45              


Leu Ile Tyr Ser Phe Ala Ser Ile Glu Asn Asn Lys Val Ile Ile Lys 
    50                  55                  60                  


Asp Lys Ser Glu Val Met Leu Tyr Gln Thr Ile Asn Ser Leu Lys Thr 
65                  70                  75                  80  


Lys Asn Pro Lys Leu Lys Ile Leu Leu Ser Ile Gly Gly Tyr Leu Phe 
                85                  90                  95      


Gly Ser Lys Gly Phe His Pro Met Val Asp Ser Ser Thr Ser Arg Leu 
            100                 105                 110         


Glu Phe Ile Asn Ser Ile Ile Leu Phe Leu Arg Asn His Asn Phe Asp 
        115                 120                 125             


Gly Leu Asp Val Ser Trp Ile Tyr Pro Asp Gln Lys Glu Asn Thr His 
    130                 135                 140                 


Phe Thr Val Leu Ile His Glu Leu Ala Glu Ala Phe Gln Lys Asp Phe 
145                 150                 155                 160 


Thr Lys Ser Thr Lys Glu Arg Leu Leu Leu Thr Ala Gly Val Ser Ala 
                165                 170                 175     


Gly Arg Gln Met Ile Asp Asn Ser Tyr Gln Val Glu Lys Leu Ala Lys 
            180                 185                 190         


Asp Leu Asp Phe Ile Asn Leu Leu Ser Phe Asp Phe His Gly Ser Trp 
        195                 200                 205             


Glu Lys Pro Leu Ile Thr Gly His Asn Ser Pro Leu Ser Lys Gly Trp 
    210                 215                 220                 


Gln Asp Arg Gly Pro Ser Ser Tyr Tyr Asn Val Glu Tyr Ala Val Gly 
225                 230                 235                 240 


Tyr Trp Ile His Lys Gly Met Pro Ser Glu Lys Val Val Met Gly Ile 
                245                 250                 255     


Pro Thr Tyr Gly His Ser Phe Thr Leu Ala Ser Ala Glu Thr Thr Val 
            260                 265                 270         


Gly Ala Pro Ala Ser Gly Pro Gly Ala Ala Gly Pro Ile Thr Glu Ser 
        275                 280                 285             


Ser Gly Phe Leu Ala Tyr Tyr Glu Ile Cys Gln Phe Leu Lys Gly Ala 
    290                 295                 300                 


Lys Ile Thr Arg Leu Gln Asp Gln Gln Val Pro Tyr Ala Val Lys Gly 
305                 310                 315                 320 


Asn Gln Trp Val Gly Tyr Asp Asp Val Lys Ser Met Glu Thr Lys Val 
                325                 330                 335     


Gln Phe Leu Lys Asn Leu Asn Leu Gly Gly Ala Met Ile Trp Ser Ile 
            340                 345                 350         


Asp Met Asp Asp Phe Thr Gly Lys Ser Cys Asn Gln Gly Pro Tyr Pro 
        355                 360                 365             


Leu Val Gln Ala Val Lys Arg Ser Leu Gly Ser Leu 
    370                 375                 380 


<210>  2771
<211>  182
<212>  PRT
<213>  Homo Sapiens

<400>  2771

Met Gly Ala Thr Thr Met Asp Gln Lys Ser Leu Trp Ala Gly Val Val 
1               5                   10                  15      


Val Leu Leu Leu Leu Gln Gly Gly Ser Ala Tyr Lys Leu Val Cys Tyr 
            20                  25                  30          


Phe Thr Asn Trp Ser Gln Asp Arg Gln Glu Pro Gly Lys Phe Thr Pro 
        35                  40                  45              


Glu Asn Ile Asp Pro Phe Leu Cys Ser His Leu Ile Tyr Ser Phe Ala 
    50                  55                  60                  


Ser Ile Glu Asn Asn Lys Val Ile Ile Lys Asp Lys Ser Glu Val Met 
65                  70                  75                  80  


Leu Tyr Gln Thr Ile Asn Ser Leu Lys Thr Lys Asn Pro Lys Leu Lys 
                85                  90                  95      


Ile Leu Leu Ser Ile Gly Gly Tyr Leu Phe Gly Ser Lys Gly Phe His 
            100                 105                 110         


Pro Met Val Asp Ser Ser Thr Ser Arg Leu Glu Phe Ile Asn Ser Ile 
        115                 120                 125             


Ile Leu Phe Leu Arg Asn His Asn Phe Asp Gly Leu Asp Glu Leu Ala 
    130                 135                 140                 


Glu Ala Phe Gln Lys Asp Phe Thr Lys Ser Thr Lys Glu Arg Leu Leu 
145                 150                 155                 160 


Leu Thr Ala Gly Val Ser Ala Gly Arg Gln Met Ile Asp Asn Ser Tyr 
                165                 170                 175     


Gln Val Glu Lys Leu Ala 
            180         


<210>  2772
<211>  201
<212>  PRT
<213>  Homo Sapiens

<400>  2772

Met Gly Ala Thr Thr Met Asp Gln Lys Ser Leu Trp Ala Gly Val Val 
1               5                   10                  15      


Val Leu Leu Leu Leu Gln Gly Gly Ser Ala Tyr Lys Leu Val Cys Tyr 
            20                  25                  30          


Phe Thr Asn Trp Ser Gln Asp Arg Gln Glu Pro Gly Lys Phe Thr Pro 
        35                  40                  45              


Glu Asn Ile Asp Pro Phe Leu Cys Ser His Leu Ile Tyr Ser Phe Ala 
    50                  55                  60                  


Ser Ile Glu Asn Asn Lys Val Ile Ile Lys Asp Lys Ser Glu Val Met 
65                  70                  75                  80  


Leu Tyr Gln Thr Ile Asn Ser Leu Lys Thr Lys Asn Pro Lys Leu Lys 
                85                  90                  95      


Ile Leu Leu Ser Ile Gly Gly Tyr Leu Phe Gly Ser Lys Gly Phe His 
            100                 105                 110         


Pro Met Val Asp Ser Ser Thr Ser Arg Leu Glu Phe Ile Asn Ser Ile 
        115                 120                 125             


Ile Leu Phe Leu Arg Asn His Asn Phe Asp Gly Leu Asp Val Ser Trp 
    130                 135                 140                 


Ile Tyr Pro Asp Gln Lys Glu Asn Thr His Phe Thr Val Leu Ile His 
145                 150                 155                 160 


Glu Leu Ala Glu Ala Phe Gln Lys Asp Phe Thr Lys Ser Thr Lys Glu 
                165                 170                 175     


Arg Leu Leu Leu Thr Ala Gly Val Ser Ala Gly Arg Gln Met Ile Asp 
            180                 185                 190         


Asn Ser Tyr Gln Val Glu Lys Leu Ala 
        195                 200     


<210>  2773
<211>  221
<212>  PRT
<213>  Homo Sapiens

<400>  2773

Met Gly Ala Thr Thr Met Asp Gln Lys Ser Leu Trp Ala Gly Val Val 
1               5                   10                  15      


Val Leu Leu Leu Leu Gln Gly Gly Ser Ala Tyr Lys Leu Val Cys Tyr 
            20                  25                  30          


Phe Thr Asn Trp Ser Gln Asp Arg Gln Glu Pro Gly Lys Phe Thr Pro 
        35                  40                  45              


Glu Asn Ile Asp Pro Phe Leu Cys Ser His Leu Ile Tyr Ser Phe Ala 
    50                  55                  60                  


Ser Ile Glu Asn Asn Lys Val Ile Ile Lys Asp Lys Ser Glu Val Met 
65                  70                  75                  80  


Leu Tyr Gln Thr Ile Asn Ser Leu Lys Thr Lys Asn Pro Lys Leu Lys 
                85                  90                  95      


Ile Leu Leu Ser Ile Gly Gly Tyr Leu Phe Gly Ser Lys Gly Phe His 
            100                 105                 110         


Pro Met Val Asp Ser Ser Thr Ser Arg Leu Glu Phe Ile Asn Ser Ile 
        115                 120                 125             


Ile Leu Phe Leu Arg Asn His Asn Phe Asp Gly Leu Asp Val Ser Trp 
    130                 135                 140                 


Ile Tyr Pro Asp Gln Lys Glu Asn Thr His Phe Thr Val Leu Ile His 
145                 150                 155                 160 


Glu Leu Ala Glu Ala Phe Gln Lys Asp Phe Thr Lys Ser Thr Lys Glu 
                165                 170                 175     


Arg Leu Leu Leu Thr Ala Gly Val Ser Ala Gly Arg Gln Met Ile Asp 
            180                 185                 190         


Asn Ser Tyr Gln Val Glu Lys Leu Ala Lys Asp Leu Asp Phe Ile Asn 
        195                 200                 205             


Leu Leu Ser Phe Asp Phe His Gly Ser Trp Glu Lys Pro 
    210                 215                 220     


<210>  2774
<211>  390
<212>  PRT
<213>  Homo Sapiens

<400>  2774

Met Gly Ala Thr Thr Met Asp Gln Lys Ser Leu Trp Ala Gly Val Val 
1               5                   10                  15      


Val Leu Leu Leu Leu Gln Gly Gly Ser Ala Tyr Lys Leu Val Cys Tyr 
            20                  25                  30          


Phe Thr Asn Trp Ser Gln Asp Arg Gln Glu Pro Gly Lys Phe Thr Pro 
        35                  40                  45              


Glu Asn Ile Asp Pro Phe Leu Cys Ser His Leu Ile Tyr Ser Phe Ala 
    50                  55                  60                  


Ser Ile Glu Asn Asn Lys Val Ile Ile Lys Asp Lys Ser Glu Val Met 
65                  70                  75                  80  


Leu Tyr Gln Thr Ile Asn Ser Leu Lys Thr Lys Asn Pro Lys Leu Lys 
                85                  90                  95      


Ile Leu Leu Ser Ile Gly Gly Tyr Leu Phe Gly Ser Lys Gly Phe His 
            100                 105                 110         


Pro Met Val Asp Ser Ser Thr Ser Arg Leu Glu Phe Ile Asn Ser Ile 
        115                 120                 125             


Ile Leu Phe Leu Arg Asn His Asn Phe Asp Gly Leu Asp Val Ser Trp 
    130                 135                 140                 


Ile Tyr Pro Asp Gln Lys Glu Asn Thr His Phe Thr Val Leu Ile His 
145                 150                 155                 160 


Glu Leu Ala Glu Ala Phe Gln Lys Asp Phe Thr Lys Ser Thr Lys Glu 
                165                 170                 175     


Arg Leu Leu Leu Thr Ala Gly Val Ser Ala Gly Arg Gln Met Ile Asp 
            180                 185                 190         


Asn Ser Tyr Gln Val Glu Lys Leu Ala Lys Asp Leu Asp Phe Ile Asn 
        195                 200                 205             


Leu Leu Ser Phe Asp Phe His Gly Ser Trp Glu Lys Pro Leu Ile Thr 
    210                 215                 220                 


Gly His Asn Ser Pro Leu Ser Lys Gly Trp Gln Asp Arg Gly Pro Ser 
225                 230                 235                 240 


Ser Tyr Tyr Asn Val Glu Tyr Ala Val Gly Tyr Trp Ile His Lys Gly 
                245                 250                 255     


Met Pro Ser Glu Lys Val Val Met Gly Ile Pro Thr Tyr Gly His Ser 
            260                 265                 270         


Phe Thr Leu Ala Ser Ala Glu Thr Thr Val Gly Ala Pro Ala Ser Gly 
        275                 280                 285             


Pro Gly Ala Ala Gly Pro Ile Thr Glu Ser Ser Gly Phe Leu Ala Tyr 
    290                 295                 300                 


Tyr Glu Ile Cys Gln Phe Leu Lys Gly Ala Lys Ile Thr Arg Leu Gln 
305                 310                 315                 320 


Asp Gln Gln Val Pro Tyr Ala Val Lys Gly Asn Gln Trp Val Gly Tyr 
                325                 330                 335     


Asp Asp Val Lys Ser Met Glu Thr Lys Val Gln Phe Leu Lys Asn Leu 
            340                 345                 350         


Asn Leu Gly Gly Ala Met Ile Trp Ser Ile Asp Met Asp Asp Phe Thr 
        355                 360                 365             


Gly Lys Ser Cys Asn Gln Gly Pro Tyr Pro Leu Val Gln Ala Val Lys 
    370                 375                 380                 


Arg Ser Leu Gly Ser Leu 
385                 390 


<210>  2775
<211>  390
<212>  PRT
<213>  Homo Sapiens

<400>  2775

Met Gly Ala Thr Thr Met Asp Gln Lys Ser Leu Trp Ala Gly Val Val 
1               5                   10                  15      


Val Leu Leu Leu Leu Gln Gly Gly Ser Ala Tyr Lys Leu Val Cys Tyr 
            20                  25                  30          


Phe Thr Asn Trp Ser Gln Asp Arg Gln Glu Pro Gly Lys Phe Thr Pro 
        35                  40                  45              


Glu Asn Ile Asp Pro Phe Leu Cys Ser His Leu Ile Tyr Ser Phe Ala 
    50                  55                  60                  


Ser Ile Glu Asn Asn Lys Val Ile Ile Lys Asp Lys Ser Glu Val Met 
65                  70                  75                  80  


Leu Tyr Gln Thr Ile Asn Ser Leu Lys Thr Lys Asn Pro Lys Leu Lys 
                85                  90                  95      


Ile Leu Leu Ser Ile Gly Gly Tyr Leu Phe Gly Ser Lys Gly Phe His 
            100                 105                 110         


Pro Met Val Asp Ser Ser Thr Ser Arg Leu Glu Phe Ile Asn Ser Ile 
        115                 120                 125             


Ile Leu Phe Leu Arg Asn His Asn Phe Asp Gly Leu Asp Val Ser Trp 
    130                 135                 140                 


Ile Tyr Pro Asp Gln Lys Glu Asn Thr His Phe Thr Val Leu Ile His 
145                 150                 155                 160 


Glu Leu Ala Glu Ala Phe Gln Lys Asp Phe Thr Lys Ser Thr Lys Glu 
                165                 170                 175     


Arg Leu Leu Leu Thr Ala Gly Val Ser Ala Gly Arg Gln Met Ile Asp 
            180                 185                 190         


Asn Ser Tyr Gln Val Glu Lys Leu Ala Lys Asp Leu Asp Phe Ile Asn 
        195                 200                 205             


Leu Leu Ser Phe Asp Phe His Gly Ser Trp Glu Lys Pro Leu Ile Thr 
    210                 215                 220                 


Gly His Asn Ser Pro Leu Ser Lys Gly Trp Gln Asp Arg Gly Pro Ser 
225                 230                 235                 240 


Ser Tyr Tyr Asn Val Glu Tyr Ala Val Gly Tyr Trp Ile His Lys Gly 
                245                 250                 255     


Met Pro Ser Glu Lys Val Val Met Gly Ile Pro Thr Tyr Gly His Ser 
            260                 265                 270         


Phe Thr Leu Ala Ser Ala Glu Thr Thr Val Gly Ala Pro Ala Ser Gly 
        275                 280                 285             


Pro Gly Ala Ala Gly Pro Ile Thr Glu Ser Ser Gly Phe Leu Ala Tyr 
    290                 295                 300                 


Tyr Glu Ile Cys Gln Phe Leu Lys Gly Ala Lys Ile Thr Arg Leu Gln 
305                 310                 315                 320 


Asp Gln Gln Val Pro Tyr Ala Val Lys Gly Asn Gln Trp Val Gly Tyr 
                325                 330                 335     


Asp Asp Val Lys Ser Met Glu Thr Lys Val Gln Phe Leu Lys Asn Leu 
            340                 345                 350         


Asn Leu Gly Gly Ala Met Ile Trp Ser Ile Asp Met Asp Asp Phe Thr 
        355                 360                 365             


Gly Lys Ser Cys Asn Gln Gly Pro Tyr Pro Leu Val Gln Ala Val Lys 
    370                 375                 380                 


Arg Ser Leu Gly Ser Leu 
385                 390 


<210>  2776
<211>  145
<212>  PRT
<213>  Homo Sapiens

<400>  2776

Met Leu Tyr Gln Thr Ile Asn Ser Leu Lys Thr Lys Phe His Pro Met 
1               5                   10                  15      


Val Asp Ser Ser Thr Ser Arg Leu Glu Phe Ile Asn Ser Ile Ile Leu 
            20                  25                  30          


Phe Leu Arg Asn His Asn Phe Asp Gly Leu Asp Val Ser Trp Ile Tyr 
        35                  40                  45              


Pro Asp Gln Lys Glu Asn Thr His Phe Thr Val Leu Ile His Glu Leu 
    50                  55                  60                  


Ala Glu Ala Phe Gln Lys Asp Phe Thr Lys Ser Thr Lys Glu Arg Leu 
65                  70                  75                  80  


Leu Leu Thr Ala Gly Val Ser Ala Gly Arg Gln Met Ile Asp Asn Ser 
                85                  90                  95      


Tyr Gln Val Glu Lys Leu Ala Lys Asp Leu Asp Phe Ile Asn Leu Leu 
            100                 105                 110         


Ser Phe Asp Phe His Gly Ser Trp Glu Lys Pro Leu Ile Thr Gly His 
        115                 120                 125             


Asn Ser Pro Leu Ser Lys Gly Trp Gln Asp Arg Gly Pro Ser Ser Tyr 
    130                 135                 140                 


Tyr 
145 


<210>  2777
<211>  122
<212>  PRT
<213>  Homo Sapiens

<400>  2777

Met Leu Tyr Gln Thr Ile Asn Ser Leu Lys Thr Lys Asn Pro Lys Leu 
1               5                   10                  15      


Lys Ile Leu Leu Ser Ile Gly Gly Tyr Leu Phe Gly Ser Lys Gly Phe 
            20                  25                  30          


His Pro Met Val Asp Ser Ser Thr Ser Arg Leu Glu Phe Ile Asn Ser 
        35                  40                  45              


Ile Ile Leu Phe Leu Arg Asn His Asn Phe Asp Gly Leu Asp Val Ser 
    50                  55                  60                  


Trp Ile Tyr Pro Asp Gln Lys Glu Asn Thr His Phe Thr Val Leu Ile 
65                  70                  75                  80  


His Glu Leu Ala Glu Ala Phe Gln Lys Asp Phe Thr Lys Ser Thr Lys 
                85                  90                  95      


Glu Arg Leu Leu Leu Thr Ala Gly Val Ser Ala Gly Arg Gln Met Ile 
            100                 105                 110         


Asp Asn Ser Tyr Gln Val Glu Lys Leu Ala 
        115                 120         


<210>  2778
<211>  169
<212>  PRT
<213>  Homo Sapiens

<400>  2778

Met Leu Tyr Gln Thr Ile Asn Ser Leu Lys Thr Lys Asn Pro Lys Leu 
1               5                   10                  15      


Lys Ile Leu Leu Ser Ile Gly Gly Tyr Leu Phe Gly Ser Lys Gly Phe 
            20                  25                  30          


His Pro Met Val Asp Ser Ser Thr Ser Arg Leu Glu Phe Ile Asn Ser 
        35                  40                  45              


Ile Ile Leu Phe Leu Arg Asn His Asn Phe Asp Gly Leu Asp Val Ser 
    50                  55                  60                  


Trp Ile Tyr Pro Asp Gln Lys Glu Asn Thr His Phe Thr Val Leu Ile 
65                  70                  75                  80  


His Glu Leu Ala Glu Ala Phe Gln Lys Asp Phe Thr Lys Ser Thr Lys 
                85                  90                  95      


Glu Arg Leu Leu Leu Thr Ala Gly Val Ser Ala Gly Arg Gln Met Ile 
            100                 105                 110         


Asp Asn Ser Tyr Gln Val Glu Lys Leu Ala Lys Asp Leu Asp Phe Ile 
        115                 120                 125             


Asn Leu Leu Ser Phe Asp Phe His Gly Ser Trp Glu Lys Pro Leu Ile 
    130                 135                 140                 


Thr Gly His Asn Ser Pro Leu Ser Lys Gly Trp Gln Asp Arg Gly Pro 
145                 150                 155                 160 


Ser Ser Tyr Tyr Asn Val Glu Tyr Ala 
                165                 


<210>  2779
<211>  311
<212>  PRT
<213>  Homo Sapiens

<400>  2779

Met Leu Tyr Gln Thr Ile Asn Ser Leu Lys Thr Lys Asn Pro Lys Leu 
1               5                   10                  15      


Lys Ile Leu Leu Ser Ile Gly Gly Tyr Leu Phe Gly Ser Lys Gly Phe 
            20                  25                  30          


His Pro Met Val Asp Ser Ser Thr Ser Arg Leu Glu Phe Ile Asn Ser 
        35                  40                  45              


Ile Ile Leu Phe Leu Arg Asn His Asn Phe Asp Gly Leu Asp Val Ser 
    50                  55                  60                  


Trp Ile Tyr Pro Asp Gln Lys Glu Asn Thr His Phe Thr Val Leu Ile 
65                  70                  75                  80  


His Glu Leu Ala Glu Ala Phe Gln Lys Asp Phe Thr Lys Ser Thr Lys 
                85                  90                  95      


Glu Arg Leu Leu Leu Thr Ala Gly Val Ser Ala Gly Arg Gln Met Ile 
            100                 105                 110         


Asp Asn Ser Tyr Gln Val Glu Lys Leu Ala Lys Asp Leu Asp Phe Ile 
        115                 120                 125             


Asn Leu Leu Ser Phe Asp Phe His Gly Ser Trp Glu Lys Pro Leu Ile 
    130                 135                 140                 


Thr Gly His Asn Ser Pro Leu Ser Lys Gly Trp Gln Asp Arg Gly Pro 
145                 150                 155                 160 


Ser Ser Tyr Tyr Asn Val Glu Tyr Ala Val Gly Tyr Trp Ile His Lys 
                165                 170                 175     


Gly Met Pro Ser Glu Lys Val Val Met Gly Ile Pro Thr Tyr Gly His 
            180                 185                 190         


Ser Phe Thr Leu Ala Ser Ala Glu Thr Thr Val Gly Ala Pro Ala Ser 
        195                 200                 205             


Gly Pro Gly Ala Ala Gly Pro Ile Thr Glu Ser Ser Gly Phe Leu Ala 
    210                 215                 220                 


Tyr Tyr Glu Ile Cys Gln Phe Leu Lys Gly Ala Lys Ile Thr Arg Leu 
225                 230                 235                 240 


Gln Asp Gln Gln Val Pro Tyr Ala Val Lys Gly Asn Gln Trp Val Gly 
                245                 250                 255     


Tyr Asp Asp Val Lys Ser Met Glu Thr Lys Val Gln Phe Leu Lys Asn 
            260                 265                 270         


Leu Asn Leu Gly Gly Ala Met Ile Trp Ser Ile Asp Met Asp Asp Phe 
        275                 280                 285             


Thr Gly Lys Ser Cys Asn Gln Gly Pro Tyr Pro Leu Val Gln Ala Val 
    290                 295                 300                 


Lys Arg Ser Leu Gly Ser Leu 
305                 310     


<210>  2780
<211>  311
<212>  PRT
<213>  Homo Sapiens

<400>  2780

Met Leu Tyr Gln Thr Ile Asn Ser Leu Lys Thr Lys Asn Pro Lys Leu 
1               5                   10                  15      


Lys Ile Leu Leu Ser Ile Gly Gly Tyr Leu Phe Gly Ser Lys Gly Phe 
            20                  25                  30          


His Pro Met Val Asp Ser Ser Thr Ser Arg Leu Glu Phe Ile Asn Ser 
        35                  40                  45              


Ile Ile Leu Phe Leu Arg Asn His Asn Phe Asp Gly Leu Asp Val Ser 
    50                  55                  60                  


Trp Ile Tyr Pro Asp Gln Lys Glu Asn Thr His Phe Thr Val Leu Ile 
65                  70                  75                  80  


His Glu Leu Ala Glu Ala Phe Gln Lys Asp Phe Thr Lys Ser Thr Lys 
                85                  90                  95      


Glu Arg Leu Leu Leu Thr Ala Gly Val Ser Ala Gly Arg Gln Met Ile 
            100                 105                 110         


Asp Asn Ser Tyr Gln Val Glu Lys Leu Ala Lys Asp Leu Asp Phe Ile 
        115                 120                 125             


Asn Leu Leu Ser Phe Asp Phe His Gly Ser Trp Glu Lys Pro Leu Ile 
    130                 135                 140                 


Thr Gly His Asn Ser Pro Leu Ser Lys Gly Trp Gln Asp Arg Gly Pro 
145                 150                 155                 160 


Ser Ser Tyr Tyr Asn Val Glu Tyr Ala Val Gly Tyr Trp Ile His Lys 
                165                 170                 175     


Gly Met Pro Ser Glu Lys Val Val Met Gly Ile Pro Thr Tyr Gly His 
            180                 185                 190         


Ser Phe Thr Leu Ala Ser Ala Glu Thr Thr Val Gly Ala Pro Ala Ser 
        195                 200                 205             


Gly Pro Gly Ala Ala Gly Pro Ile Thr Glu Ser Ser Gly Phe Leu Ala 
    210                 215                 220                 


Tyr Tyr Glu Ile Cys Gln Phe Leu Lys Gly Ala Lys Ile Thr Arg Leu 
225                 230                 235                 240 


Gln Asp Gln Gln Val Pro Tyr Ala Val Lys Gly Asn Gln Trp Val Gly 
                245                 250                 255     


Tyr Asp Asp Val Lys Ser Met Glu Thr Lys Val Gln Phe Leu Lys Asn 
            260                 265                 270         


Leu Asn Leu Gly Gly Ala Met Ile Trp Ser Ile Asp Met Asp Asp Phe 
        275                 280                 285             


Thr Gly Lys Ser Cys Asn Gln Gly Pro Tyr Pro Leu Val Gln Ala Val 
    290                 295                 300                 


Lys Arg Ser Leu Gly Ser Leu 
305                 310     


<210>  2781
<211>  183
<212>  PRT
<213>  Homo Sapiens

<400>  2781

Pro Asp Gln Lys Glu Asn Thr His Phe Thr Val Leu Ile His Glu Leu 
1               5                   10                  15      


Ala Glu Ala Phe Gln Lys Asp Phe Thr Lys Ser Thr Lys Glu Arg Leu 
            20                  25                  30          


Leu Leu Thr Ala Gly Val Ser Ala Gly Arg Gln Met Ile Asp Asn Ser 
        35                  40                  45              


Tyr Gln Val Glu Lys Leu Ala Lys Asp Leu Asp Phe Ile Asn Leu Leu 
    50                  55                  60                  


Ser Phe Asp Phe His Gly Ser Trp Glu Lys Pro Leu Ile Thr Gly His 
65                  70                  75                  80  


Asn Ser Pro Leu Ser Lys Gly Trp Gln Asp Arg Gly Pro Ser Ser Tyr 
                85                  90                  95      


Tyr Asn Val Ile Cys Gln Phe Leu Lys Gly Ala Lys Ile Thr Arg Leu 
            100                 105                 110         


Gln Asp Gln Gln Val Pro Tyr Ala Val Lys Gly Asn Gln Trp Val Gly 
        115                 120                 125             


Tyr Asp Asp Val Lys Ser Met Glu Thr Lys Val Gln Phe Leu Lys Asn 
    130                 135                 140                 


Leu Asn Leu Gly Gly Ala Met Ile Trp Ser Ile Asp Met Asp Asp Phe 
145                 150                 155                 160 


Thr Gly Lys Ser Cys Asn Gln Gly Pro Tyr Pro Leu Val Gln Ala Val 
                165                 170                 175     


Lys Arg Ser Leu Gly Ser Leu 
            180             


<210>  2782
<211>  161
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2782

Xaa Phe Thr Asn Trp Ser Gln Asp Arg Gln Glu Pro Gly Lys Phe Thr 
1               5                   10                  15      


Pro Glu Asn Ile Asp Pro Phe Leu Cys Ser His Leu Ile Tyr Ser Phe 
            20                  25                  30          


Ala Ser Ile Glu Asn Asn Lys Val Ile Ile Lys Asp Lys Ser Glu Val 
        35                  40                  45              


Met Leu Tyr Gln Thr Ile Asn Ser Leu Lys Thr Lys Asn Pro Lys Leu 
    50                  55                  60                  


Lys Ile Leu Leu Ser Ile Gly Gly Tyr Leu Phe Gly Ser Lys Gly Asp 
65                  70                  75                  80  


Leu Asp Phe Ile Asn Leu Leu Ser Phe Asp Phe His Gly Ser Trp Glu 
                85                  90                  95      


Lys Pro Leu Ile Thr Gly His Asn Ser Pro Leu Ser Lys Gly Trp Gln 
            100                 105                 110         


Asp Arg Gly Pro Ser Ser Tyr Tyr Asn Val Glu Tyr Ala Val Gly Tyr 
        115                 120                 125             


Trp Ile His Lys Gly Met Pro Ser Glu Lys Val Val Met Gly Ile Pro 
    130                 135                 140                 


Thr Tyr Gly His Ser Phe Thr Leu Ala Ser Ala Glu Thr Thr Val Gly 
145                 150                 155                 160 


Ala 
    


<210>  2783
<211>  42
<212>  PRT
<213>  Homo Sapiens

<400>  2783

Tyr Glu Ile Cys Gln Phe Leu Lys Gly Ala Lys Ile Thr Arg Leu Gln 
1               5                   10                  15      


Asp Gln Gln Val Pro Tyr Ala Val Lys Gly Asn Gln Trp Val Gly Tyr 
            20                  25                  30          


Asp Asp Val Lys Ser Met Glu Thr Lys Asp 
        35                  40          


<210>  2784
<211>  420
<212>  PRT
<213>  Homo Sapiens

<400>  2784

Glu Thr Ser Ser Ser Val His Glu Gln Val Ala Asp Ser Gly Ala Gln 
1               5                   10                  15      


Ala Val Ala Phe Gln Ser Gly Gly Glu Ser Ser Ile Val Trp Asn Ser 
            20                  25                  30          


Gln Leu Lys Thr Leu Leu Ala Ile Gly Gly Trp Asn Phe Gly Thr Ala 
        35                  40                  45              


Pro Phe Thr Ala Met Val Ser Thr Pro Glu Asn Arg Gln Thr Phe Ile 
    50                  55                  60                  


Thr Ser Val Ile Lys Phe Leu Arg Gln Tyr Glu Phe Asp Gly Leu Asp 
65                  70                  75                  80  


Phe Asp Trp Glu Tyr Pro Gly Ser Arg Gly Ser Pro Pro Gln Asp Lys 
                85                  90                  95      


His Leu Phe Thr Val Leu Val Gln Glu Met Arg Glu Ala Phe Glu Gln 
            100                 105                 110         


Glu Ala Lys Gln Ile Asn Lys Pro Arg Leu Met Val Thr Ala Ala Val 
        115                 120                 125             


Ala Ala Gly Ile Ser Asn Ile Gln Ser Gly Tyr Glu Ile Pro Gln Leu 
    130                 135                 140                 


Ser Gln Tyr Leu Asp Tyr Ile His Val Met Thr Tyr Asp Leu His Gly 
145                 150                 155                 160 


Ser Trp Glu Gly Tyr Thr Gly Glu Asn Ser Pro Leu Tyr Lys Tyr Pro 
                165                 170                 175     


Thr Asp Thr Gly Ser Asn Ala Tyr Leu Asn Val Asp Tyr Val Met Asn 
            180                 185                 190         


Tyr Trp Lys Asp Asn Gly Ala Pro Ala Glu Lys Leu Ile Val Gly Phe 
        195                 200                 205             


Pro Thr Tyr Gly His Asn Phe Ile Leu Ser Asn Pro Ser Asn Thr Gly 
    210                 215                 220                 


Ile Gly Ala Pro Thr Ser Gly Ala Gly Pro Ala Gly Pro Tyr Ala Lys 
225                 230                 235                 240 


Glu Ser Gly Ile Trp Ala Tyr Tyr Glu Ile Cys Thr Phe Leu Lys Asn 
                245                 250                 255     


Gly Ala Thr Gln Gly Trp Asp Ala Pro Gln Glu Val Pro Tyr Ala Tyr 
            260                 265                 270         


Gln Gly Asn Val Trp Val Gly Tyr Asp Asn Ile Lys Ser Phe Asp Ile 
        275                 280                 285             


Lys Ala Gln Trp Leu Lys His Asn Lys Phe Gly Gly Ala Met Val Trp 
    290                 295                 300                 


Ala Ile Asp Leu Asp Asp Phe Thr Gly Thr Phe Cys Asn Gln Gly Lys 
305                 310                 315                 320 


Phe Pro Leu Ile Ser Thr Leu Lys Lys Ala Leu Gly Leu Gln Ser Ala 
                325                 330                 335     


Ser Cys Thr Ala Pro Ala Gln Pro Ile Glu Pro Ile Thr Ala Ala Pro 
            340                 345                 350         


Ser Gly Ser Gly Asn Gly Ser Gly Ser Ser Ser Ser Gly Gly Ser Ser 
        355                 360                 365             


Gly Gly Ser Gly Phe Cys Ala Val Arg Ala Asn Gly Leu Tyr Pro Val 
    370                 375                 380                 


Ala Asn Asn Arg Asn Ala Phe Trp His Cys Val Asn Gly Val Thr Tyr 
385                 390                 395                 400 


Gln Gln Asn Cys Gln Ala Gly Leu Val Phe Asp Thr Ser Cys Asp Cys 
                405                 410                 415     


Cys Asn Trp Ala 
            420 


<210>  2785
<211>  315
<212>  PRT
<213>  Homo Sapiens

<400>  2785

Met Arg Glu Ala Phe Glu Gln Glu Ala Lys Gln Ile Asn Lys Pro Arg 
1               5                   10                  15      


Leu Met Val Thr Ala Ala Val Ala Ala Gly Ile Ser Asn Ile Gln Ser 
            20                  25                  30          


Gly Tyr Glu Ile Pro Gln Leu Ser Gln Tyr Leu Asp Tyr Ile His Val 
        35                  40                  45              


Met Thr Tyr Asp Leu His Gly Ser Trp Glu Gly Tyr Thr Gly Glu Asn 
    50                  55                  60                  


Ser Pro Leu Tyr Lys Tyr Pro Thr Asp Thr Gly Ser Asn Ala Tyr Leu 
65                  70                  75                  80  


Asn Val Asp Tyr Val Met Asn Tyr Trp Lys Asp Asn Gly Ala Pro Ala 
                85                  90                  95      


Glu Lys Leu Ile Val Gly Phe Pro Thr Tyr Gly His Asn Phe Ile Leu 
            100                 105                 110         


Ser Asn Pro Ser Asn Thr Gly Ile Gly Ala Pro Thr Ser Gly Ala Gly 
        115                 120                 125             


Pro Ala Gly Pro Tyr Ala Lys Glu Ser Gly Ile Trp Ala Tyr Tyr Glu 
    130                 135                 140                 


Ile Cys Thr Phe Leu Lys Asn Gly Ala Thr Gln Gly Trp Asp Ala Pro 
145                 150                 155                 160 


Gln Glu Val Pro Tyr Ala Tyr Gln Gly Asn Val Trp Val Gly Tyr Asp 
                165                 170                 175     


Asn Ile Lys Ser Phe Asp Ile Lys Ala Gln Trp Leu Lys His Asn Lys 
            180                 185                 190         


Phe Gly Gly Ala Met Val Trp Ala Ile Asp Leu Asp Asp Phe Thr Gly 
        195                 200                 205             


Thr Phe Cys Asn Gln Gly Lys Phe Pro Leu Ile Ser Thr Leu Lys Lys 
    210                 215                 220                 


Ala Leu Gly Leu Gln Ser Ala Ser Cys Thr Ala Pro Ala Gln Pro Ile 
225                 230                 235                 240 


Glu Pro Ile Thr Ala Ala Pro Ser Gly Ser Gly Asn Gly Ser Gly Ser 
                245                 250                 255     


Ser Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly Phe Cys Ala Val Arg 
            260                 265                 270         


Ala Asn Gly Leu Tyr Pro Val Ala Asn Asn Arg Asn Ala Phe Trp His 
        275                 280                 285             


Cys Val Asn Gly Val Thr Tyr Gln Gln Asn Cys Gln Ala Gly Leu Val 
    290                 295                 300                 


Phe Asp Thr Ser Cys Asp Cys Cys Asn Trp Ala 
305                 310                 315 


<210>  2786
<211>  315
<212>  PRT
<213>  Homo Sapiens

<400>  2786

Met Arg Glu Ala Phe Glu Gln Glu Ala Lys Gln Ile Asn Lys Pro Arg 
1               5                   10                  15      


Leu Met Val Thr Ala Ala Val Ala Ala Gly Ile Ser Asn Ile Gln Ser 
            20                  25                  30          


Gly Tyr Glu Ile Pro Gln Leu Ser Gln Tyr Leu Asp Tyr Ile His Val 
        35                  40                  45              


Met Thr Tyr Asp Leu His Gly Ser Trp Glu Gly Tyr Thr Gly Glu Asn 
    50                  55                  60                  


Ser Pro Leu Tyr Lys Tyr Pro Thr Asp Thr Gly Ser Asn Ala Tyr Leu 
65                  70                  75                  80  


Asn Val Asp Tyr Val Met Asn Tyr Trp Lys Asp Asn Gly Ala Pro Ala 
                85                  90                  95      


Glu Lys Leu Ile Val Gly Phe Pro Thr Tyr Gly His Asn Phe Ile Leu 
            100                 105                 110         


Ser Asn Pro Ser Asn Thr Gly Ile Gly Ala Pro Thr Ser Gly Ala Gly 
        115                 120                 125             


Pro Ala Gly Pro Tyr Ala Lys Glu Ser Gly Ile Trp Ala Tyr Tyr Glu 
    130                 135                 140                 


Ile Cys Thr Phe Leu Lys Asn Gly Ala Thr Gln Gly Trp Asp Ala Pro 
145                 150                 155                 160 


Gln Glu Val Pro Tyr Ala Tyr Gln Gly Asn Val Trp Val Gly Tyr Asp 
                165                 170                 175     


Asn Ile Lys Ser Phe Asp Ile Lys Ala Gln Trp Leu Lys His Asn Lys 
            180                 185                 190         


Phe Gly Gly Ala Met Val Trp Ala Ile Asp Leu Asp Asp Phe Thr Gly 
        195                 200                 205             


Thr Phe Cys Asn Gln Gly Lys Phe Pro Leu Ile Ser Thr Leu Lys Lys 
    210                 215                 220                 


Ala Leu Gly Leu Gln Ser Ala Ser Cys Thr Ala Pro Ala Gln Pro Ile 
225                 230                 235                 240 


Glu Pro Ile Thr Ala Ala Pro Ser Gly Ser Gly Asn Gly Ser Gly Ser 
                245                 250                 255     


Ser Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly Phe Cys Ala Val Arg 
            260                 265                 270         


Ala Asn Gly Leu Tyr Pro Val Ala Asn Asn Arg Asn Ala Phe Trp His 
        275                 280                 285             


Cys Val Asn Gly Val Thr Tyr Gln Gln Asn Cys Gln Ala Gly Leu Val 
    290                 295                 300                 


Phe Asp Thr Ser Cys Asp Cys Cys Asn Trp Ala 
305                 310                 315 


<210>  2787
<211>  287
<212>  PRT
<213>  Homo Sapiens

<400>  2787

Met Arg Glu Ala Phe Glu Gln Glu Ala Lys Gln Ile Asn Lys Pro Arg 
1               5                   10                  15      


Leu Met Val Thr Ala Ala Val Ala Ala Gly Ile Ser Asn Ile Gln Ser 
            20                  25                  30          


Gly Tyr Glu Ile Pro Gln Leu Ser Gln Tyr Leu Asp Tyr Ile His Val 
        35                  40                  45              


Met Thr Tyr Asp Leu His Gly Ser Trp Glu Gly Tyr Thr Gly Glu Asn 
    50                  55                  60                  


Ser Pro Leu Tyr Lys Tyr Pro Thr Asp Thr Gly Ser Asn Ala Tyr Leu 
65                  70                  75                  80  


Asn Val Asp Tyr Val Met Asn Tyr Trp Lys Asp Asn Gly Ala Pro Ala 
                85                  90                  95      


Glu Lys Leu Ile Val Gly Phe Pro Thr Tyr Gly His Asn Phe Ile Leu 
            100                 105                 110         


Ser Asn Pro Ser Asn Thr Gly Ile Gly Ala Pro Thr Ser Gly Ala Gly 
        115                 120                 125             


Pro Ala Gly Pro Tyr Ala Lys Glu Ser Gly Ile Trp Ala Tyr Tyr Glu 
    130                 135                 140                 


Ile Cys Thr Phe Leu Lys Asn Gly Ala Thr Gln Gly Trp Asp Ala Pro 
145                 150                 155                 160 


Gln Glu Val Pro Tyr Ala Tyr Gln Gly Asn Val Trp Val Gly Tyr Asp 
                165                 170                 175     


Asn Ile Lys Ser Phe Asp Ile Lys Ala Gln Trp Leu Lys His Asn Lys 
            180                 185                 190         


Phe Gly Gly Ala Met Val Trp Ala Ile Asp Leu Asp Asp Phe Thr Gly 
        195                 200                 205             


Thr Phe Cys Asn Gln Gly Lys Phe Pro Leu Ile Ser Thr Leu Lys Lys 
    210                 215                 220                 


Ala Leu Gly Leu Gln Ser Ala Ser Cys Thr Ala Pro Ala Gln Pro Ile 
225                 230                 235                 240 


Glu Pro Ile Thr Ala Ala Pro Ser Gly Ser Gly Asn Gly Ser Gly Ser 
                245                 250                 255     


Ser Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly Phe Cys Ala Val Arg 
            260                 265                 270         


Ala Asn Gly Leu Tyr Pro Val Ala Asn Asn Arg Asn Ala Phe Trp 
        275                 280                 285         


<210>  2788
<211>  315
<212>  PRT
<213>  Homo Sapiens

<400>  2788

Met Arg Glu Ala Phe Glu Gln Glu Ala Lys Gln Ile Asn Lys Pro Arg 
1               5                   10                  15      


Leu Met Val Thr Ala Ala Val Ala Ala Gly Ile Ser Asn Ile Gln Ser 
            20                  25                  30          


Gly Tyr Glu Ile Pro Gln Leu Ser Gln Tyr Leu Asp Tyr Ile His Val 
        35                  40                  45              


Met Thr Tyr Asp Leu His Gly Ser Trp Glu Gly Tyr Thr Gly Glu Asn 
    50                  55                  60                  


Ser Pro Leu Tyr Lys Tyr Pro Thr Asp Thr Gly Ser Asn Ala Tyr Leu 
65                  70                  75                  80  


Asn Val Asp Tyr Val Met Asn Tyr Trp Lys Asp Asn Gly Ala Pro Ala 
                85                  90                  95      


Glu Lys Leu Ile Val Gly Phe Pro Thr Tyr Gly His Asn Phe Ile Leu 
            100                 105                 110         


Ser Asn Pro Ser Asn Thr Gly Ile Gly Ala Pro Thr Ser Gly Ala Gly 
        115                 120                 125             


Pro Ala Gly Pro Tyr Ala Lys Glu Ser Gly Ile Trp Ala Tyr Tyr Glu 
    130                 135                 140                 


Ile Cys Thr Phe Leu Lys Asn Gly Ala Thr Gln Gly Trp Asp Ala Pro 
145                 150                 155                 160 


Gln Glu Val Pro Tyr Ala Tyr Gln Gly Asn Val Trp Val Gly Tyr Asp 
                165                 170                 175     


Asn Ile Lys Ser Phe Asp Ile Lys Ala Gln Trp Leu Lys His Asn Lys 
            180                 185                 190         


Phe Gly Gly Ala Met Val Trp Ala Ile Asp Leu Asp Asp Phe Thr Gly 
        195                 200                 205             


Thr Phe Cys Asn Gln Gly Lys Phe Pro Leu Ile Ser Thr Leu Lys Lys 
    210                 215                 220                 


Ala Leu Gly Leu Gln Ser Ala Ser Cys Thr Ala Pro Ala Gln Pro Ile 
225                 230                 235                 240 


Glu Pro Ile Thr Ala Ala Pro Ser Gly Ser Gly Asn Gly Ser Gly Ser 
                245                 250                 255     


Ser Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly Phe Cys Ala Val Arg 
            260                 265                 270         


Ala Asn Gly Leu Tyr Pro Val Ala Asn Asn Arg Asn Ala Phe Trp His 
        275                 280                 285             


Cys Val Asn Gly Val Thr Tyr Gln Gln Asn Cys Gln Ala Gly Leu Val 
    290                 295                 300                 


Phe Asp Thr Ser Cys Asp Cys Cys Asn Trp Ala 
305                 310                 315 


<210>  2789
<211>  476
<212>  PRT
<213>  Homo Sapiens

<400>  2789

Met Thr Lys Leu Ile Leu Leu Thr Gly Leu Val Leu Ile Leu Asn Leu 
1               5                   10                  15      


Gln Leu Gly Ser Ala Tyr Gln Leu Thr Cys Tyr Phe Thr Asn Trp Ala 
            20                  25                  30          


Gln Tyr Arg Pro Gly Leu Gly Arg Phe Met Pro Asp Asn Ile Asp Pro 
        35                  40                  45              


Cys Leu Cys Thr His Leu Ile Tyr Ala Phe Ala Gly Arg Gln Asn Asn 
    50                  55                  60                  


Glu Ile Thr Thr Ile Glu Trp Asn Asp Val Thr Leu Tyr Gln Ala Phe 
65                  70                  75                  80  


Asn Gly Leu Lys Asn Lys Asn Ser Gln Leu Lys Thr Leu Leu Ala Ile 
                85                  90                  95      


Gly Gly Trp Asn Phe Gly Thr Ala Pro Phe Thr Ala Met Val Ser Thr 
            100                 105                 110         


Pro Glu Asn Arg Gln Thr Phe Ile Thr Ser Val Ile Lys Phe Leu Arg 
        115                 120                 125             


Gln Tyr Glu Phe Asp Gly Leu Asp Phe Asp Trp Glu Tyr Pro Gly Ser 
    130                 135                 140                 


Arg Gly Ser Pro Pro Gln Asp Lys His Leu Phe Thr Val Leu Val Gln 
145                 150                 155                 160 


Glu Met Arg Glu Ala Phe Glu Gln Glu Ala Lys Gln Ile Asn Lys Pro 
                165                 170                 175     


Arg Leu Met Val Thr Ala Ala Val Ala Ala Gly Ile Ser Asn Ile Gln 
            180                 185                 190         


Ser Gly Tyr Glu Ile Pro Gln Leu Ser Gln Tyr Leu Asp Tyr Ile His 
        195                 200                 205             


Val Met Thr Tyr Asp Leu His Gly Ser Trp Glu Gly Tyr Thr Gly Glu 
    210                 215                 220                 


Asn Ser Pro Leu Tyr Lys Tyr Pro Thr Asp Thr Gly Ser Asn Ala Tyr 
225                 230                 235                 240 


Leu Asn Val Asp Tyr Val Met Asn Tyr Trp Lys Asp Asn Gly Ala Pro 
                245                 250                 255     


Ala Glu Lys Leu Ile Val Gly Phe Pro Thr Tyr Gly His Asn Phe Ile 
            260                 265                 270         


Leu Ser Asn Pro Ser Asn Thr Gly Ile Gly Ala Pro Thr Ser Gly Ala 
        275                 280                 285             


Gly Pro Ala Gly Pro Tyr Ala Lys Glu Ser Gly Ile Trp Ala Tyr Tyr 
    290                 295                 300                 


Glu Ile Cys Thr Phe Leu Lys Asn Gly Ala Thr Gln Gly Trp Asp Ala 
305                 310                 315                 320 


Pro Gln Glu Val Pro Tyr Ala Tyr Gln Gly Asn Val Trp Val Gly Tyr 
                325                 330                 335     


Asp Asn Ile Lys Ser Phe Asp Ile Lys Ala Gln Trp Leu Lys His Asn 
            340                 345                 350         


Lys Phe Gly Gly Ala Met Val Trp Ala Ile Asp Leu Asp Asp Phe Thr 
        355                 360                 365             


Gly Thr Phe Cys Asn Gln Gly Lys Phe Pro Leu Ile Ser Thr Leu Lys 
    370                 375                 380                 


Lys Ala Leu Gly Leu Gln Ser Ala Ser Cys Thr Ala Pro Ala Gln Pro 
385                 390                 395                 400 


Ile Glu Pro Ile Thr Ala Ala Pro Ser Gly Ser Gly Asn Gly Ser Gly 
                405                 410                 415     


Ser Ser Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly Phe Cys Ala Val 
            420                 425                 430         


Arg Ala Asn Gly Leu Tyr Pro Val Ala Asn Asn Arg Asn Ala Phe Trp 
        435                 440                 445             


His Cys Val Asn Gly Val Thr Tyr Gln Gln Asn Cys Gln Ala Gly Leu 
    450                 455                 460                 


Val Phe Asp Thr Ser Cys Asp Cys Cys Asn Trp Ala 
465                 470                 475     


<210>  2790
<211>  476
<212>  PRT
<213>  Homo Sapiens

<400>  2790

Met Thr Lys Leu Ile Leu Leu Thr Gly Leu Val Leu Ile Leu Asn Leu 
1               5                   10                  15      


Gln Leu Gly Ser Ala Tyr Gln Leu Thr Cys Tyr Phe Thr Asn Trp Ala 
            20                  25                  30          


Gln Tyr Arg Pro Gly Leu Gly Arg Phe Met Pro Asp Asn Ile Asp Pro 
        35                  40                  45              


Cys Leu Cys Thr His Leu Ile Tyr Ala Phe Ala Gly Arg Gln Asn Asn 
    50                  55                  60                  


Glu Ile Thr Thr Ile Glu Trp Asn Asp Val Thr Leu Tyr Gln Ala Phe 
65                  70                  75                  80  


Asn Gly Leu Lys Asn Lys Asn Ser Gln Leu Lys Thr Leu Leu Ala Ile 
                85                  90                  95      


Gly Gly Trp Asn Phe Gly Thr Ala Pro Phe Thr Ala Met Val Ser Thr 
            100                 105                 110         


Pro Glu Asn Arg Gln Thr Phe Ile Thr Ser Val Ile Lys Phe Leu Arg 
        115                 120                 125             


Gln Tyr Glu Phe Asp Gly Leu Asp Phe Asp Trp Glu Tyr Pro Gly Ser 
    130                 135                 140                 


Arg Gly Ser Pro Pro Gln Asp Lys His Leu Phe Thr Val Leu Val Gln 
145                 150                 155                 160 


Glu Met Arg Glu Ala Phe Glu Gln Glu Ala Lys Gln Ile Asn Lys Pro 
                165                 170                 175     


Arg Leu Met Val Thr Ala Ala Val Ala Ala Gly Ile Ser Asn Ile Gln 
            180                 185                 190         


Ser Gly Tyr Glu Ile Pro Gln Leu Ser Gln Tyr Leu Asp Tyr Ile His 
        195                 200                 205             


Val Met Thr Tyr Asp Leu His Gly Ser Trp Glu Gly Tyr Thr Gly Glu 
    210                 215                 220                 


Asn Ser Pro Leu Tyr Lys Tyr Pro Thr Asp Thr Gly Ser Asn Ala Tyr 
225                 230                 235                 240 


Leu Asn Val Asp Tyr Val Met Asn Tyr Trp Lys Asp Asn Gly Ala Pro 
                245                 250                 255     


Ala Glu Lys Leu Ile Val Gly Phe Pro Thr Tyr Gly His Asn Phe Ile 
            260                 265                 270         


Leu Ser Asn Pro Ser Asn Thr Gly Ile Gly Ala Pro Thr Ser Gly Ala 
        275                 280                 285             


Gly Pro Ala Gly Pro Tyr Ala Lys Glu Ser Gly Ile Trp Ala Tyr Tyr 
    290                 295                 300                 


Glu Ile Cys Thr Phe Leu Lys Asn Gly Ala Thr Gln Gly Trp Asp Ala 
305                 310                 315                 320 


Pro Gln Glu Val Pro Tyr Ala Tyr Gln Gly Asn Val Trp Val Gly Tyr 
                325                 330                 335     


Asp Asn Ile Lys Ser Phe Asp Ile Lys Ala Gln Trp Leu Lys His Asn 
            340                 345                 350         


Lys Phe Gly Gly Ala Met Val Trp Ala Ile Asp Leu Asp Asp Phe Thr 
        355                 360                 365             


Gly Thr Phe Cys Asn Gln Gly Lys Phe Pro Leu Ile Ser Thr Leu Lys 
    370                 375                 380                 


Lys Ala Leu Gly Leu Gln Ser Ala Ser Cys Thr Ala Pro Ala Gln Pro 
385                 390                 395                 400 


Ile Glu Pro Ile Thr Ala Ala Pro Ser Gly Ser Gly Asn Gly Ser Gly 
                405                 410                 415     


Ser Ser Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly Phe Cys Ala Val 
            420                 425                 430         


Arg Ala Asn Gly Leu Tyr Pro Val Ala Asn Asn Arg Asn Ala Phe Trp 
        435                 440                 445             


His Cys Val Asn Gly Val Thr Tyr Gln Gln Asn Cys Gln Ala Gly Leu 
    450                 455                 460                 


Val Phe Asp Thr Ser Cys Asp Cys Cys Asn Trp Ala 
465                 470                 475     


<210>  2791
<211>  368
<212>  PRT
<213>  Homo Sapiens

<400>  2791

Met Val Ser Thr Pro Glu Asn Arg Gln Thr Phe Ile Thr Ser Val Ile 
1               5                   10                  15      


Lys Phe Leu Arg Gln Tyr Glu Phe Asp Gly Leu Asp Phe Asp Trp Glu 
            20                  25                  30          


Tyr Pro Gly Ser Arg Gly Ser Pro Pro Gln Asp Lys His Leu Phe Thr 
        35                  40                  45              


Val Leu Val Gln Glu Met Arg Glu Ala Phe Glu Gln Glu Ala Lys Gln 
    50                  55                  60                  


Ile Asn Lys Pro Arg Leu Met Val Thr Ala Ala Val Ala Ala Gly Ile 
65                  70                  75                  80  


Ser Asn Ile Gln Ser Gly Tyr Glu Ile Pro Gln Leu Ser Gln Tyr Leu 
                85                  90                  95      


Asp Tyr Ile His Val Met Thr Tyr Asp Leu His Gly Ser Trp Glu Gly 
            100                 105                 110         


Tyr Thr Gly Glu Asn Ser Pro Leu Tyr Lys Tyr Pro Thr Asp Thr Gly 
        115                 120                 125             


Ser Asn Ala Tyr Leu Asn Val Asp Tyr Val Met Asn Tyr Trp Lys Asp 
    130                 135                 140                 


Asn Gly Ala Pro Ala Glu Lys Leu Ile Val Gly Phe Pro Thr Tyr Gly 
145                 150                 155                 160 


His Asn Phe Ile Leu Ser Asn Pro Ser Asn Thr Gly Ile Gly Ala Pro 
                165                 170                 175     


Thr Ser Gly Ala Gly Pro Ala Gly Pro Tyr Ala Lys Glu Ser Gly Ile 
            180                 185                 190         


Trp Ala Tyr Tyr Glu Ile Cys Thr Phe Leu Lys Asn Gly Ala Thr Gln 
        195                 200                 205             


Gly Trp Asp Ala Pro Gln Glu Val Pro Tyr Ala Tyr Gln Gly Asn Val 
    210                 215                 220                 


Trp Val Gly Tyr Asp Asn Ile Lys Ser Phe Asp Ile Lys Ala Gln Trp 
225                 230                 235                 240 


Leu Lys His Asn Lys Phe Gly Gly Ala Met Val Trp Ala Ile Asp Leu 
                245                 250                 255     


Asp Asp Phe Thr Gly Thr Phe Cys Asn Gln Gly Lys Phe Pro Leu Ile 
            260                 265                 270         


Ser Thr Leu Lys Lys Ala Leu Gly Leu Gln Ser Ala Ser Cys Thr Ala 
        275                 280                 285             


Pro Ala Gln Pro Ile Glu Pro Ile Thr Ala Ala Pro Ser Gly Ser Gly 
    290                 295                 300                 


Asn Gly Ser Gly Ser Ser Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly 
305                 310                 315                 320 


Phe Cys Ala Val Arg Ala Asn Gly Leu Tyr Pro Val Ala Asn Asn Arg 
                325                 330                 335     


Asn Ala Phe Trp His Cys Val Asn Gly Val Thr Tyr Gln Gln Asn Cys 
            340                 345                 350         


Gln Ala Gly Leu Val Phe Asp Thr Ser Cys Asp Cys Cys Asn Trp Ala 
        355                 360                 365             


<210>  2792
<211>  101
<212>  PRT
<213>  Homo Sapiens

<400>  2792

Met Val Ser Thr Pro Glu Asn Arg Gln Thr Phe Ile Thr Ser Val Ile 
1               5                   10                  15      


Lys Phe Leu Arg Gln Tyr Glu Phe Asp Gly Leu Asp Phe Asp Trp Glu 
            20                  25                  30          


Tyr Pro Gly Ser Arg Gly Ser Pro Pro Gln Asp Lys His Leu Phe Thr 
        35                  40                  45              


Val Leu Val Gln Met Arg Lys Leu Lys Tyr Arg Glu Asp Leu Ser Asn 
    50                  55                  60                  


Leu Pro Lys Ile Thr Gln Leu Val Gly Ile Ile Thr Ser Ser Ala Val 
65                  70                  75                  80  


Trp Pro Gln Ser Pro Leu Leu Leu Ser Ile Thr Leu Gly Cys Pro Leu 
                85                  90                  95      


Leu Leu Arg Asn Ala 
            100     


<210>  2793
<211>  69
<212>  PRT
<213>  Homo Sapiens

<400>  2793

Leu Lys Asp His Arg Pro Arg Met Val Trp Asp Ser Gln Ala Ser Glu 
1               5                   10                  15      


His Phe Phe Glu Tyr Lys Lys Ser Arg Ser Gly Arg His Val Val Phe 
            20                  25                  30          


Tyr Pro Thr Leu Lys Ser Leu Gln Val Arg Leu Glu Leu Ala Arg Glu 
        35                  40                  45              


Leu Gly Val Gly Val Ser Ile Trp Glu Leu Gly Gln Gly Leu Asp Tyr 
    50                  55                  60                  


Phe Tyr Asp Leu Leu 
65                  


<210>  2794
<211>  26
<212>  PRT
<213>  Homo Sapiens

<400>  2794

Met Arg Thr Leu Phe Asn Leu Leu Trp Leu Ala Leu Ala Cys Ser Pro 
1               5                   10                  15      


Val His Thr Thr Leu Ser Lys Ser Asp Ala 
            20                  25      


<210>  2795
<211>  84
<212>  PRT
<213>  Homo Sapiens

<400>  2795

Met Arg Thr Leu Phe Asn Leu Leu Trp Leu Ala Leu Ala Cys Ser Pro 
1               5                   10                  15      


Val His Thr Thr Leu Ser Lys Ser Asp Ala Lys Lys Ala Ala Ser Lys 
            20                  25                  30          


Thr Leu Leu Glu Lys Ala Gly Ala Gln Trp Arg Asp Leu Gly Ser Pro 
        35                  40                  45              


Gln Pro Leu Pro Pro Arg Phe Lys Arg Phe Ser Cys Phe Ser Leu Pro 
    50                  55                  60                  


Ser Ser Trp Asp Tyr Arg Val Ser Phe Gln Ile Ser Arg Cys Lys Thr 
65                  70                  75                  80  


Gly Val Trp Trp 
                


<210>  2796
<211>  84
<212>  PRT
<213>  Homo Sapiens

<400>  2796

Met Arg Thr Leu Phe Asn Leu Leu Trp Leu Ala Leu Ala Cys Ser Pro 
1               5                   10                  15      


Val His Thr Thr Leu Ser Lys Ser Asp Ala Lys Lys Ala Ala Ser Lys 
            20                  25                  30          


Thr Leu Leu Glu Lys Ser Gln Phe Ser Asp Lys Pro Val Gln Asp Arg 
        35                  40                  45              


Gly Leu Val Val Thr Asp Leu Lys Ala Glu Ser Val Val Leu Glu His 
    50                  55                  60                  


Arg Ser Tyr Cys Ser Ala Lys Ala Arg Asp Arg His Phe Ala Gly Asp 
65                  70                  75                  80  


Val Leu Gly Tyr 
                


<210>  2797
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  2797

Met Arg Thr Leu Phe Asn Leu Leu Trp Leu Ala Leu Ala Cys Ser Pro 
1               5                   10                  15      


Val His Thr Thr Leu Ser Lys Ser Asp Ala Lys Lys Ala Ala Ser Lys 
            20                  25                  30          


Thr Leu Leu Glu Lys Ser Gln Phe Ser Asp Lys Pro Val Gln Asp Arg 
        35                  40                  45              


Gly Leu Val Val Thr Asp Leu Lys Ala Glu Ser Val Val Leu Glu His 
    50                  55                  60                  


Arg Ser Tyr Cys Ser Ala Lys Ala Arg Asp Arg His Phe Ala Gly Asp 
65                  70                  75                  80  


Val Leu Gly Tyr Val Thr Pro Trp Asn Ser His Gly Tyr Asp Val Thr 
                85                  90                  95      


Lys Val Phe Gly Ser Lys Phe Thr Gln Ile Ser Pro Val Trp Leu Gln 
            100                 105                 110         


Leu Lys Arg Arg 
        115     


<210>  2798
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  2798

Met Arg Thr Leu Phe Asn Leu Leu Trp Leu Ala Leu Ala Cys Ser Pro 
1               5                   10                  15      


Val His Thr Thr Leu Ser Lys Ser Asp Ala Lys Lys Ala Ala Ser Lys 
            20                  25                  30          


Thr Leu Leu Glu Lys Ser Gln Phe Ser Asp Lys Pro Val Gln Asp Arg 
        35                  40                  45              


Gly Leu Val Val Thr Asp Leu Lys Ala Glu Ser Val Val Leu Glu His 
    50                  55                  60                  


Arg Ser Tyr Cys Ser Ala Lys Ala Arg Asp Arg His Phe Ala Gly Asp 
65                  70                  75                  80  


Val Leu Gly Tyr Val Thr Pro Trp Asn Ser His Gly Tyr Asp Val Thr 
                85                  90                  95      


Lys Val Phe Gly Ser Lys Phe Thr Gln Ile Ser Pro Val Trp Leu Gln 
            100                 105                 110         


Leu Lys Arg Arg Gly Arg Glu 
        115                 


<210>  2799
<211>  224
<212>  PRT
<213>  Homo Sapiens

<400>  2799

Met Arg Thr Leu Phe Asn Leu Leu Trp Leu Ala Leu Ala Cys Ser Pro 
1               5                   10                  15      


Val His Thr Thr Leu Ser Lys Ser Asp Ala Lys Lys Ala Ala Ser Lys 
            20                  25                  30          


Thr Leu Leu Glu Lys Ser Gln Phe Ser Asp Lys Pro Val Gln Asp Arg 
        35                  40                  45              


Gly Leu Val Val Thr Asp Leu Lys Ala Glu Ser Val Val Leu Glu His 
    50                  55                  60                  


Arg Ser Tyr Cys Ser Ala Lys Ala Arg Asp Arg His Phe Ala Gly Asp 
65                  70                  75                  80  


Val Leu Gly Tyr Val Thr Pro Trp Asn Ser His Gly Tyr Asp Val Thr 
                85                  90                  95      


Lys Val Phe Gly Ser Lys Phe Thr Gln Ile Ser Pro Val Trp Leu Gln 
            100                 105                 110         


Leu Lys Arg Arg Gly Arg Glu Met Phe Glu Ala Arg Leu Leu Ala Leu 
        115                 120                 125             


Leu Val Ile Pro Pro Ala Ile Thr Pro Gly Thr Asp Gln Leu Gly Met 
    130                 135                 140                 


Phe Thr His Lys Glu Phe Glu Gln Leu Ala Pro Val Leu Asp Gly Phe 
145                 150                 155                 160 


Ser Leu Met Thr Tyr Asp Tyr Ser Thr Ala His Gln Pro Gly Pro Asn 
                165                 170                 175     


Ala Pro Leu Ser Trp Val Arg Ala Cys Val Gln Val Leu Asp Pro Lys 
            180                 185                 190         


Ser Lys Trp Arg Ser Lys Ile Leu Leu Gly Leu Asn Phe Tyr Gly Met 
        195                 200                 205             


Asp Tyr Ala Thr Ser Lys Asp Ala Arg Glu Pro Val Val Gly Ala Arg 
    210                 215                 220                 


<210>  2800
<211>  132
<212>  PRT
<213>  Homo Sapiens

<400>  2800

Met Arg Thr Leu Phe Asn Leu Leu Trp Leu Ala Leu Ala Cys Ser Pro 
1               5                   10                  15      


Val His Thr Thr Leu Ser Lys Ser Asp Ala Lys Lys Ala Ala Ser Lys 
            20                  25                  30          


Thr Leu Leu Glu Lys Ser Gln Phe Ser Asp Lys Pro Val Gln Asp Arg 
        35                  40                  45              


Gly Leu Val Val Thr Asp Leu Lys Ala Glu Ser Val Val Leu Glu His 
    50                  55                  60                  


Arg Ser Tyr Cys Ser Ala Lys Ala Arg Asp Arg His Phe Ala Gly Asp 
65                  70                  75                  80  


Val Leu Gly Tyr Val Thr Pro Trp Asn Ser His Gly Tyr Asp Val Thr 
                85                  90                  95      


Lys Val Phe Gly Ser Lys Phe Thr Gln Ile Ser Pro Val Trp Leu Gln 
            100                 105                 110         


Leu Lys Arg Arg Gly Arg Glu Met Phe Glu Val Thr Gly Leu His Asp 
        115                 120                 125             


Val Asp Gln Gly 
    130         


<210>  2801
<211>  162
<212>  PRT
<213>  Homo Sapiens

<400>  2801

Met Arg Thr Leu Phe Asn Leu Leu Trp Leu Ala Leu Ala Cys Ser Pro 
1               5                   10                  15      


Val His Thr Thr Leu Ser Lys Ser Asp Ala Lys Lys Ala Ala Ser Lys 
            20                  25                  30          


Thr Leu Leu Glu Lys Ser Gln Phe Ser Asp Lys Pro Val Gln Asp Arg 
        35                  40                  45              


Gly Leu Val Val Thr Asp Leu Lys Ala Glu Ser Val Val Leu Glu His 
    50                  55                  60                  


Arg Ser Tyr Cys Ser Ala Lys Ala Arg Asp Arg His Phe Ala Gly Asp 
65                  70                  75                  80  


Val Leu Gly Tyr Val Thr Pro Trp Asn Ser His Gly Tyr Asp Val Thr 
                85                  90                  95      


Lys Val Phe Gly Ser Lys Phe Thr Gln Ile Ser Pro Val Trp Leu Gln 
            100                 105                 110         


Leu Lys Arg Arg Gly Arg Glu Met Phe Glu Val Thr Gly Leu His Asp 
        115                 120                 125             


Val Asp Gln Gly Ser His Pro Ser Cys Leu Thr Val Leu Ala Pro Gln 
    130                 135                 140                 


Ala Glu Lys Ser Gly Gly Cys Glu Leu Ser Gly Ser Met Pro Arg Ala 
145                 150                 155                 160 


Cys Thr 
        


<210>  2802
<211>  393
<212>  PRT
<213>  Homo Sapiens

<400>  2802

Met Arg Thr Leu Phe Asn Leu Leu Trp Leu Ala Leu Ala Cys Ser Pro 
1               5                   10                  15      


Val His Thr Thr Leu Ser Lys Ser Asp Ala Lys Lys Ala Ala Ser Lys 
            20                  25                  30          


Thr Leu Leu Glu Lys Ser Gln Phe Ser Asp Lys Pro Val Gln Asp Arg 
        35                  40                  45              


Gly Leu Val Val Thr Asp Leu Lys Ala Glu Ser Val Val Leu Glu His 
    50                  55                  60                  


Arg Ser Tyr Cys Ser Ala Lys Ala Arg Asp Arg His Phe Ala Gly Asp 
65                  70                  75                  80  


Val Leu Gly Tyr Val Thr Pro Trp Asn Ser His Gly Tyr Asp Val Thr 
                85                  90                  95      


Lys Val Phe Gly Ser Lys Phe Thr Gln Ile Ser Pro Val Trp Leu Gln 
            100                 105                 110         


Leu Lys Arg Arg Gly Arg Glu Met Phe Glu Val Thr Gly Leu His Asp 
        115                 120                 125             


Val Asp Gln Gly Trp Met Arg Ala Val Arg Lys His Ala Lys Gly Leu 
    130                 135                 140                 


His Ile Val Pro Arg Leu Leu Phe Glu Asp Trp Thr Tyr Asp Asp Phe 
145                 150                 155                 160 


Arg Asn Val Leu Asp Ser Glu Asp Glu Ile Glu Glu Leu Ser Lys Thr 
                165                 170                 175     


Val Val Gln Val Ala Lys Asn Gln His Phe Asp Gly Phe Val Val Glu 
            180                 185                 190         


Val Trp Asn Gln Leu Leu Ser Gln Lys Arg Val Gly Leu Ile His Met 
        195                 200                 205             


Leu Thr His Leu Ala Glu Ala Leu His Gln Ala Arg Leu Leu Ala Leu 
    210                 215                 220                 


Leu Val Ile Pro Pro Ala Ile Thr Pro Gly Thr Asp Gln Leu Gly Met 
225                 230                 235                 240 


Phe Thr His Lys Glu Phe Glu Gln Leu Ala Pro Val Leu Asp Gly Phe 
                245                 250                 255     


Ser Leu Met Thr Tyr Asp Tyr Ser Thr Ala His Gln Pro Gly Pro Asn 
            260                 265                 270         


Ala Pro Leu Ser Trp Val Arg Ala Cys Val Gln Val Leu Asp Pro Lys 
        275                 280                 285             


Ser Lys Trp Arg Ser Lys Ile Leu Leu Gly Leu Asn Phe Tyr Gly Met 
    290                 295                 300                 


Asp Tyr Ala Thr Ser Lys Asp Ala Arg Glu Pro Val Val Gly Ala Arg 
305                 310                 315                 320 


Tyr Ile Gln Thr Leu Lys Asp His Arg Pro Arg Met Val Trp Asp Ser 
                325                 330                 335     


Gln Ala Ser Glu His Phe Phe Glu Tyr Lys Lys Ser Arg Ser Gly Arg 
            340                 345                 350         


His Val Val Phe Tyr Pro Thr Leu Lys Ser Leu Gln Val Arg Leu Glu 
        355                 360                 365             


Leu Ala Arg Glu Leu Gly Val Gly Val Ser Ile Trp Glu Leu Gly Gln 
    370                 375                 380                 


Gly Leu Asp Tyr Phe Tyr Asp Leu Leu 
385                 390             


<210>  2803
<211>  393
<212>  PRT
<213>  Homo Sapiens

<400>  2803

Met Arg Thr Leu Phe Asn Leu Leu Trp Leu Ala Leu Ala Cys Ser Pro 
1               5                   10                  15      


Val His Thr Thr Leu Ser Lys Ser Asp Ala Lys Lys Ala Ala Ser Lys 
            20                  25                  30          


Thr Leu Leu Glu Lys Ser Gln Phe Ser Asp Lys Pro Val Gln Asp Arg 
        35                  40                  45              


Gly Leu Val Val Thr Asp Leu Lys Ala Glu Ser Val Val Leu Glu His 
    50                  55                  60                  


Arg Ser Tyr Cys Ser Ala Lys Ala Arg Asp Arg His Phe Ala Gly Asp 
65                  70                  75                  80  


Val Leu Gly Tyr Val Thr Pro Trp Asn Ser His Gly Tyr Asp Val Thr 
                85                  90                  95      


Lys Val Phe Gly Ser Lys Phe Thr Gln Ile Ser Pro Val Trp Leu Gln 
            100                 105                 110         


Leu Lys Arg Arg Gly Arg Glu Met Phe Glu Val Thr Gly Leu His Asp 
        115                 120                 125             


Val Asp Gln Gly Trp Met Arg Ala Val Arg Lys His Ala Lys Gly Leu 
    130                 135                 140                 


His Ile Val Pro Arg Leu Leu Phe Glu Asp Trp Thr Tyr Asp Asp Phe 
145                 150                 155                 160 


Arg Asn Val Leu Asp Ser Glu Asp Glu Ile Glu Glu Leu Ser Lys Thr 
                165                 170                 175     


Val Val Gln Val Ala Lys Asn Gln His Phe Asp Gly Phe Val Val Glu 
            180                 185                 190         


Val Trp Asn Gln Leu Leu Ser Gln Lys Arg Val Gly Leu Ile His Met 
        195                 200                 205             


Leu Thr His Leu Ala Glu Ala Leu His Gln Ala Arg Leu Leu Ala Leu 
    210                 215                 220                 


Leu Val Ile Pro Pro Ala Ile Thr Pro Gly Thr Asp Gln Leu Gly Met 
225                 230                 235                 240 


Phe Thr His Lys Glu Phe Glu Gln Leu Ala Pro Val Leu Asp Gly Phe 
                245                 250                 255     


Ser Leu Met Thr Tyr Asp Tyr Ser Thr Ala His Gln Pro Gly Pro Asn 
            260                 265                 270         


Ala Pro Leu Ser Trp Val Arg Ala Cys Val Gln Val Leu Asp Pro Lys 
        275                 280                 285             


Ser Lys Trp Arg Ser Lys Ile Leu Leu Gly Leu Asn Phe Tyr Gly Met 
    290                 295                 300                 


Asp Tyr Ala Thr Ser Lys Asp Ala Arg Glu Pro Val Val Gly Ala Arg 
305                 310                 315                 320 


Tyr Ile Gln Thr Leu Lys Asp His Arg Pro Arg Met Val Trp Asp Ser 
                325                 330                 335     


Gln Ala Ser Glu His Phe Phe Glu Tyr Lys Lys Ser Arg Ser Gly Arg 
            340                 345                 350         


His Val Val Phe Tyr Pro Thr Leu Lys Ser Leu Gln Val Arg Leu Glu 
        355                 360                 365             


Leu Ala Arg Glu Leu Gly Val Gly Val Ser Ile Trp Glu Leu Gly Gln 
    370                 375                 380                 


Gly Leu Asp Tyr Phe Tyr Asp Leu Leu 
385                 390             


<210>  2804
<211>  393
<212>  PRT
<213>  Homo Sapiens

<400>  2804

Met Arg Thr Leu Phe Asn Leu Leu Trp Leu Ala Leu Ala Cys Ser Pro 
1               5                   10                  15      


Val His Thr Thr Leu Ser Lys Ser Asp Ala Lys Lys Ala Ala Ser Lys 
            20                  25                  30          


Thr Leu Leu Glu Lys Ser Gln Phe Ser Asp Lys Pro Val Gln Asp Arg 
        35                  40                  45              


Gly Leu Val Val Thr Asp Leu Lys Ala Glu Ser Val Val Leu Glu His 
    50                  55                  60                  


Arg Ser Tyr Cys Ser Ala Lys Ala Arg Asp Arg His Phe Ala Gly Asp 
65                  70                  75                  80  


Val Leu Gly Tyr Val Thr Pro Trp Asn Ser His Gly Tyr Asp Val Thr 
                85                  90                  95      


Lys Val Phe Gly Ser Lys Phe Thr Gln Ile Ser Pro Val Trp Leu Gln 
            100                 105                 110         


Leu Lys Arg Arg Gly Arg Glu Met Phe Glu Val Thr Gly Leu His Asp 
        115                 120                 125             


Val Asp Gln Gly Trp Met Arg Ala Val Arg Lys His Ala Lys Gly Leu 
    130                 135                 140                 


His Ile Val Pro Arg Leu Leu Phe Glu Asp Trp Thr Tyr Asp Asp Phe 
145                 150                 155                 160 


Arg Asn Val Leu Asp Ser Glu Asp Glu Ile Glu Glu Leu Ser Lys Thr 
                165                 170                 175     


Val Val Gln Val Ala Lys Asn Gln His Phe Asp Gly Phe Val Val Glu 
            180                 185                 190         


Val Trp Asn Gln Leu Leu Ser Gln Lys Arg Val Gly Leu Ile His Met 
        195                 200                 205             


Leu Thr His Leu Ala Glu Ala Leu His Gln Ala Arg Leu Leu Ala Leu 
    210                 215                 220                 


Leu Val Ile Pro Pro Ala Ile Thr Pro Gly Thr Asp Gln Leu Gly Met 
225                 230                 235                 240 


Phe Thr His Lys Glu Phe Glu Gln Leu Ala Pro Val Leu Asp Gly Phe 
                245                 250                 255     


Ser Leu Met Thr Tyr Asp Tyr Ser Thr Ala His Gln Pro Gly Pro Asn 
            260                 265                 270         


Ala Pro Leu Ser Trp Val Arg Ala Cys Val Gln Val Leu Asp Pro Lys 
        275                 280                 285             


Ser Lys Trp Arg Ser Lys Ile Leu Leu Gly Leu Asn Phe Tyr Gly Met 
    290                 295                 300                 


Asp Tyr Ala Thr Ser Lys Asp Ala Arg Glu Pro Val Val Gly Ala Arg 
305                 310                 315                 320 


Tyr Ile Gln Thr Leu Lys Asp His Arg Pro Arg Met Val Trp Asp Ser 
                325                 330                 335     


Gln Ala Ser Glu His Phe Phe Glu Tyr Lys Lys Ser Arg Ser Gly Arg 
            340                 345                 350         


His Val Val Phe Tyr Pro Thr Leu Lys Ser Leu Gln Val Arg Leu Glu 
        355                 360                 365             


Leu Ala Arg Glu Leu Gly Val Gly Val Ser Ile Trp Glu Leu Gly Gln 
    370                 375                 380                 


Gly Leu Asp Tyr Phe Tyr Asp Leu Leu 
385                 390             


<210>  2805
<211>  362
<212>  PRT
<213>  Homo Sapiens

<400>  2805

Met Arg Thr Leu Phe Asn Leu Leu Trp Leu Ala Leu Ala Cys Ser Pro 
1               5                   10                  15      


Val His Thr Thr Leu Ser Lys Ser Asp Ala Lys Lys Ala Ala Ser Lys 
            20                  25                  30          


Thr Leu Leu Glu Lys Ser Gln Phe Ser Asp Lys Pro Val Gln Asp Arg 
        35                  40                  45              


Gly Leu Val Val Thr Asp Leu Lys Ala Glu Ser Val Val Leu Glu His 
    50                  55                  60                  


Arg Ser Tyr Cys Ser Ala Lys Ala Arg Asp Arg His Phe Ala Gly Asp 
65                  70                  75                  80  


Val Leu Gly Tyr Val Thr Pro Trp Asn Ser His Gly Tyr Asp Val Thr 
                85                  90                  95      


Lys Val Phe Gly Ser Lys Phe Thr Gln Ile Ser Pro Val Trp Leu Gln 
            100                 105                 110         


Leu Lys Arg Arg Gly Arg Glu Met Phe Glu Val Thr Gly Leu His Asp 
        115                 120                 125             


Val Asp Gln Gly Trp Met Arg Ala Val Arg Lys His Ala Lys Gly Leu 
    130                 135                 140                 


His Ile Val Pro Arg Leu Leu Phe Glu Asp Trp Thr Tyr Asp Asp Phe 
145                 150                 155                 160 


Arg Asn Val Leu Asp Ser Glu Asp Glu Ile Glu Glu Leu Ser Lys Thr 
                165                 170                 175     


Val Val Gln Val Ala Lys Asn Gln His Phe Asp Gly Phe Val Val Glu 
            180                 185                 190         


Val Trp Asn Gln Leu Leu Ser Gln Lys Arg Val Thr Asp Gln Leu Gly 
        195                 200                 205             


Met Phe Thr His Lys Glu Phe Glu Gln Leu Ala Pro Val Leu Asp Gly 
    210                 215                 220                 


Phe Ser Leu Met Thr Tyr Asp Tyr Ser Thr Ala His Gln Pro Gly Pro 
225                 230                 235                 240 


Asn Ala Pro Leu Ser Trp Val Arg Ala Cys Val Gln Val Leu Asp Pro 
                245                 250                 255     


Lys Ser Lys Trp Arg Ser Lys Ile Leu Leu Gly Leu Asn Phe Tyr Gly 
            260                 265                 270         


Met Asp Tyr Ala Thr Ser Lys Asp Ala Arg Glu Pro Val Val Gly Ala 
        275                 280                 285             


Arg Tyr Ile Gln Thr Leu Lys Asp His Arg Pro Arg Met Val Trp Asp 
    290                 295                 300                 


Ser Gln Ala Ser Glu His Phe Phe Glu Tyr Lys Lys Ser Arg Ser Gly 
305                 310                 315                 320 


Arg His Val Val Phe Tyr Pro Thr Leu Lys Ser Leu Gln Val Arg Leu 
                325                 330                 335     


Glu Leu Ala Arg Glu Leu Gly Val Gly Val Ser Ile Trp Glu Leu Gly 
            340                 345                 350         


Gln Gly Leu Asp Tyr Phe Tyr Asp Leu Leu 
        355                 360         


<210>  2806
<211>  38
<212>  PRT
<213>  Homo Sapiens

<400>  2806

Met Arg Thr Leu Phe Asn Leu Leu Trp Leu Ala Leu Ala Cys Ser Pro 
1               5                   10                  15      


Val His Thr Thr Leu Ser Lys Ser Asp Ala Lys Lys Ala Ala Ser Lys 
            20                  25                  30          


Thr Leu Leu Glu Lys Val 
        35              


<210>  2807
<211>  418
<212>  PRT
<213>  Homo Sapiens

<400>  2807

Met Arg Thr Leu Phe Asn Leu Leu Trp Leu Ala Leu Ala Cys Ser Pro 
1               5                   10                  15      


Val His Thr Thr Leu Ser Lys Ser Asp Ala Lys Lys Ala Ala Ser Lys 
            20                  25                  30          


Thr Leu Leu Glu Lys Val Lys Phe Cys Ser Cys Cys Pro Gly Trp Ser 
        35                  40                  45              


Ala Met Ala Arg Ser Trp Leu Thr Ala Thr Ser Ala Thr Gln Ser Gln 
    50                  55                  60                  


Phe Ser Asp Lys Pro Val Gln Asp Arg Gly Leu Val Val Thr Asp Leu 
65                  70                  75                  80  


Lys Ala Glu Ser Val Val Leu Glu His Arg Ser Tyr Cys Ser Ala Lys 
                85                  90                  95      


Ala Arg Asp Arg His Phe Ala Gly Asp Val Leu Gly Tyr Val Thr Pro 
            100                 105                 110         


Trp Asn Ser His Gly Tyr Asp Val Thr Lys Val Phe Gly Ser Lys Phe 
        115                 120                 125             


Thr Gln Ile Ser Pro Val Trp Leu Gln Leu Lys Arg Arg Gly Arg Glu 
    130                 135                 140                 


Met Phe Glu Val Thr Gly Leu His Asp Val Asp Gln Gly Trp Met Arg 
145                 150                 155                 160 


Ala Val Arg Lys His Ala Lys Gly Leu His Ile Val Pro Arg Leu Leu 
                165                 170                 175     


Phe Glu Asp Trp Thr Tyr Asp Asp Phe Arg Asn Val Leu Asp Ser Glu 
            180                 185                 190         


Asp Glu Ile Glu Glu Leu Ser Lys Thr Val Val Gln Val Ala Lys Asn 
        195                 200                 205             


Gln His Phe Asp Gly Phe Val Val Glu Val Trp Asn Gln Leu Leu Ser 
    210                 215                 220                 


Gln Lys Arg Val Gly Leu Ile His Met Leu Thr His Leu Ala Glu Ala 
225                 230                 235                 240 


Leu His Gln Ala Arg Leu Leu Ala Leu Leu Val Ile Pro Pro Ala Ile 
                245                 250                 255     


Thr Pro Gly Thr Asp Gln Leu Gly Met Phe Thr His Lys Glu Phe Glu 
            260                 265                 270         


Gln Leu Ala Pro Val Leu Asp Gly Phe Ser Leu Met Thr Tyr Asp Tyr 
        275                 280                 285             


Ser Thr Ala His Gln Pro Gly Pro Asn Ala Pro Leu Ser Trp Val Arg 
    290                 295                 300                 


Ala Cys Val Gln Val Leu Asp Pro Lys Ser Lys Trp Arg Ser Lys Ile 
305                 310                 315                 320 


Leu Leu Gly Leu Asn Phe Tyr Gly Met Asp Tyr Ala Thr Ser Lys Asp 
                325                 330                 335     


Ala Arg Glu Pro Val Val Gly Ala Arg Tyr Ile Gln Thr Leu Lys Asp 
            340                 345                 350         


His Arg Pro Arg Met Val Trp Asp Ser Gln Ala Ser Glu His Phe Phe 
        355                 360                 365             


Glu Tyr Lys Lys Ser Arg Ser Gly Arg His Val Val Phe Tyr Pro Thr 
    370                 375                 380                 


Leu Lys Ser Leu Gln Val Arg Leu Glu Leu Ala Arg Glu Leu Gly Val 
385                 390                 395                 400 


Gly Val Ser Ile Trp Glu Leu Gly Gln Gly Leu Asp Tyr Phe Tyr Asp 
                405                 410                 415     


Leu Leu 
        


<210>  2808
<211>  418
<212>  PRT
<213>  Homo Sapiens

<400>  2808

Met Arg Thr Leu Phe Asn Leu Leu Trp Leu Ala Leu Ala Cys Ser Pro 
1               5                   10                  15      


Val His Thr Thr Leu Ser Lys Ser Asp Ala Lys Lys Ala Ala Ser Lys 
            20                  25                  30          


Thr Leu Leu Glu Lys Val Lys Phe Cys Ser Cys Cys Pro Gly Trp Ser 
        35                  40                  45              


Ala Met Ala Arg Ser Trp Leu Thr Ala Thr Ser Ala Thr Gln Ser Gln 
    50                  55                  60                  


Phe Ser Asp Lys Pro Val Gln Asp Arg Gly Leu Val Val Thr Asp Leu 
65                  70                  75                  80  


Lys Ala Glu Ser Val Val Leu Glu His Arg Ser Tyr Cys Ser Ala Lys 
                85                  90                  95      


Ala Arg Asp Arg His Phe Ala Gly Asp Val Leu Gly Tyr Val Thr Pro 
            100                 105                 110         


Trp Asn Ser His Gly Tyr Asp Val Thr Lys Val Phe Gly Ser Lys Phe 
        115                 120                 125             


Thr Gln Ile Ser Pro Val Trp Leu Gln Leu Lys Arg Arg Gly Arg Glu 
    130                 135                 140                 


Met Phe Glu Val Thr Gly Leu His Asp Val Asp Gln Gly Trp Met Arg 
145                 150                 155                 160 


Ala Val Arg Lys His Ala Lys Gly Leu His Ile Val Pro Arg Leu Leu 
                165                 170                 175     


Phe Glu Asp Trp Thr Tyr Asp Asp Phe Arg Asn Val Leu Asp Ser Glu 
            180                 185                 190         


Asp Glu Ile Glu Glu Leu Ser Lys Thr Val Val Gln Val Ala Lys Asn 
        195                 200                 205             


Gln His Phe Asp Gly Phe Val Val Glu Val Trp Asn Gln Leu Leu Ser 
    210                 215                 220                 


Gln Lys Arg Val Gly Leu Ile His Met Leu Thr His Leu Ala Glu Ala 
225                 230                 235                 240 


Leu His Gln Ala Arg Leu Leu Ala Leu Leu Val Ile Pro Pro Ala Ile 
                245                 250                 255     


Thr Pro Gly Thr Asp Gln Leu Gly Met Phe Thr His Lys Glu Phe Glu 
            260                 265                 270         


Gln Leu Ala Pro Val Leu Asp Gly Phe Ser Leu Met Thr Tyr Asp Tyr 
        275                 280                 285             


Ser Thr Ala His Gln Pro Gly Pro Asn Ala Pro Leu Ser Trp Val Arg 
    290                 295                 300                 


Ala Cys Val Gln Val Leu Asp Pro Lys Ser Lys Trp Arg Ser Lys Ile 
305                 310                 315                 320 


Leu Leu Gly Leu Asn Phe Tyr Gly Met Asp Tyr Ala Thr Ser Lys Asp 
                325                 330                 335     


Ala Arg Glu Pro Val Val Gly Ala Arg Tyr Ile Gln Thr Leu Lys Asp 
            340                 345                 350         


His Arg Pro Arg Met Val Trp Asp Ser Gln Ala Ser Glu His Phe Phe 
        355                 360                 365             


Glu Tyr Lys Lys Ser Arg Ser Gly Arg His Val Val Phe Tyr Pro Thr 
    370                 375                 380                 


Leu Lys Ser Leu Gln Val Arg Leu Glu Leu Ala Arg Glu Leu Gly Val 
385                 390                 395                 400 


Gly Val Ser Ile Trp Glu Leu Gly Gln Gly Leu Asp Tyr Phe Tyr Asp 
                405                 410                 415     


Leu Leu 
        


<210>  2809
<211>  84
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2809

Xaa Asp Ala Arg Glu Pro Val Val Gly Ala Arg Tyr Ile Gln Thr Leu 
1               5                   10                  15      


Lys Asp His Arg Pro Arg Met Val Trp Asp Ser Gln Ala Ser Glu His 
            20                  25                  30          


Phe Phe Glu Tyr Lys Lys Ser Arg Ser Gly Arg His Val Val Phe Tyr 
        35                  40                  45              


Pro Thr Leu Lys Ser Leu Gln Val Arg Leu Glu Leu Ala Arg Glu Leu 
    50                  55                  60                  


Gly Val Gly Val Ser Ile Trp Glu Leu Gly Gln Gly Leu Asp Tyr Phe 
65                  70                  75                  80  


Tyr Asp Leu Leu 
                


<210>  2810
<211>  108
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2810

Xaa Pro Lys Ser Lys Trp Arg Ser Lys Ile Leu Leu Gly Leu Asn Phe 
1               5                   10                  15      


Tyr Gly Met Asp Tyr Ala Thr Ser Lys Asp Ala Arg Glu Pro Val Val 
            20                  25                  30          


Gly Ala Arg Tyr Ile Gln Thr Leu Lys Asp His Arg Pro Arg Met Val 
        35                  40                  45              


Trp Asp Ser Gln Ala Ser Glu His Phe Phe Glu Tyr Lys Lys Ser Arg 
    50                  55                  60                  


Ser Gly Arg His Val Val Phe Tyr Pro Thr Leu Lys Ser Leu Gln Val 
65                  70                  75                  80  


Arg Leu Glu Leu Ala Arg Glu Leu Gly Val Gly Val Ser Ile Trp Glu 
                85                  90                  95      


Leu Gly Gln Gly Leu Asp Tyr Phe Tyr Asp Leu Leu 
            100                 105             


<210>  2811
<211>  72
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2811

Xaa Gln Leu Gly Met Phe Thr His Lys Glu Phe Glu Gln Leu Ala Pro 
1               5                   10                  15      


Val Leu Asp Gly Phe Ser Leu Met Thr Tyr Asp Tyr Ser Thr Ala His 
            20                  25                  30          


Gln Pro Gly Pro Asn Ala Pro Leu Ser Trp Val Arg Ala Cys Val Gln 
        35                  40                  45              


Val Leu Asp Pro Lys Ser Lys Trp Arg Ser Lys Ile Leu Leu Gly Leu 
    50                  55                  60                  


Asn Phe Tyr Gly Thr Ser Arg His 
65                  70          


<210>  2812
<211>  447
<212>  PRT
<213>  Homo Sapiens

<400>  2812

Met Val Arg Ser Val Ala Trp Ala Gly Phe Met Val Leu Leu Met Ile 
1               5                   10                  15      


Pro Trp Gly Ser Ala Ala Lys Leu Val Cys Tyr Phe Thr Asn Trp Ala 
            20                  25                  30          


Gln Tyr Arg Gln Gly Glu Ala Arg Phe Leu Pro Lys Asp Leu Asp Pro 
        35                  40                  45              


Ser Leu Cys Thr His Leu Ile Tyr Ala Phe Ala Gly Met Thr Asn His 
    50                  55                  60                  


Gln Leu Ser Thr Thr Glu Trp Asn Asp Glu Thr Leu Tyr Gln Glu Phe 
65                  70                  75                  80  


Asn Gly Leu Lys Lys Met Phe Thr Asp Met Val Ala Thr Ala Asn Asn 
                85                  90                  95      


Arg Gln Thr Phe Val Asn Ser Ala Ile Arg Phe Leu Arg Lys Tyr Ser 
            100                 105                 110         


Phe Asp Gly Leu Asp Leu Asp Trp Glu Tyr Pro Gly Ser Gln Gly Ser 
        115                 120                 125             


Pro Ala Val Asp Lys Glu Arg Phe Thr Thr Leu Val Gln Asp Leu Ala 
    130                 135                 140                 


Asn Ala Phe Gln Gln Glu Ala Gln Thr Ser Gly Lys Glu Arg Leu Leu 
145                 150                 155                 160 


Leu Ser Ala Ala Val Pro Ala Gly Gln Thr Tyr Val Asp Ala Gly Tyr 
                165                 170                 175     


Glu Val Asp Lys Ile Ala Gln Asn Leu Asp Phe Val Asn Leu Met Ala 
            180                 185                 190         


Tyr Asp Phe His Gly Ser Trp Glu Lys Val Thr Gly His Asn Ser Pro 
        195                 200                 205             


Leu Tyr Lys Arg Gln Glu Glu Ser Gly Ala Ala Ala Ser Leu Asn Val 
    210                 215                 220                 


Asp Ala Ala Val Gln Gln Trp Leu Gln Lys Gly Thr Pro Ala Ser Lys 
225                 230                 235                 240 


Leu Ile Leu Gly Met Pro Thr Tyr Gly Arg Ser Phe Thr Leu Ala Ser 
                245                 250                 255     


Ser Ser Asp Thr Arg Val Gly Ala Pro Ala Thr Gly Ser Gly Thr Pro 
            260                 265                 270         


Gly Pro Phe Thr Lys Glu Gly Gly Met Leu Ala Tyr Tyr Glu Val Cys 
        275                 280                 285             


Ser Trp Lys Gly Ala Thr Lys Gln Arg Ile Gln Asp Gln Lys Val Pro 
    290                 295                 300                 


Tyr Ile Phe Arg Asp Asn Gln Trp Val Gly Phe Asp Asp Val Glu Ser 
305                 310                 315                 320 


Phe Lys Thr Lys Val Ser Tyr Leu Lys Gln Lys Gly Leu Gly Gly Ala 
                325                 330                 335     


Met Val Trp Ala Leu Asp Leu Asp Asp Phe Ala Gly Phe Ser Cys Asn 
            340                 345                 350         


Gln Gly Arg Tyr Pro Leu Ile Gln Thr Leu Arg Gln Glu Leu Ser Leu 
        355                 360                 365             


Pro Tyr Leu Pro Ser Gly Thr Pro Glu Leu Glu Val Pro Lys Pro Gly 
    370                 375                 380                 


Gln Pro Ser Glu Pro Glu His Gly Pro Ser Pro Gly Gln Asp Thr Phe 
385                 390                 395                 400 


Cys Gln Gly Lys Ala Asp Gly Leu Tyr Pro Asn Pro Arg Glu Arg Ser 
                405                 410                 415     


Ser Phe Tyr Ser Cys Ala Ala Gly Arg Leu Phe Gln Gln Ser Cys Pro 
            420                 425                 430         


Thr Gly Leu Val Phe Ser Asn Ser Cys Lys Cys Cys Thr Trp Asn 
        435                 440                 445         


<210>  2813
<211>  466
<212>  PRT
<213>  Homo Sapiens

<400>  2813

Met Val Arg Ser Val Ala Trp Ala Gly Phe Met Val Leu Leu Met Ile 
1               5                   10                  15      


Pro Trp Gly Ser Ala Ala Lys Leu Val Cys Tyr Phe Thr Asn Trp Ala 
            20                  25                  30          


Gln Tyr Arg Gln Gly Glu Ala Arg Phe Leu Pro Lys Asp Leu Asp Pro 
        35                  40                  45              


Ser Leu Cys Thr His Leu Ile Tyr Ala Phe Ala Gly Met Thr Asn His 
    50                  55                  60                  


Gln Leu Ser Thr Thr Glu Trp Asn Asp Glu Thr Leu Tyr Gln Glu Phe 
65                  70                  75                  80  


Asn Gly Leu Lys Lys Met Asn Pro Lys Leu Lys Thr Leu Leu Ala Ile 
                85                  90                  95      


Gly Gly Trp Asn Phe Gly Thr Gln Lys Phe Thr Asp Met Val Ala Thr 
            100                 105                 110         


Ala Asn Asn Arg Gln Thr Phe Val Asn Ser Ala Ile Arg Phe Leu Arg 
        115                 120                 125             


Lys Tyr Ser Phe Asp Gly Leu Asp Leu Asp Trp Glu Tyr Pro Gly Ser 
    130                 135                 140                 


Gln Gly Ser Pro Ala Val Asp Lys Glu Arg Phe Thr Thr Leu Val Gln 
145                 150                 155                 160 


Asp Leu Ala Asn Ala Phe Gln Gln Glu Ala Gln Thr Ser Gly Lys Glu 
                165                 170                 175     


Arg Leu Leu Leu Ser Ala Ala Val Pro Ala Gly Gln Thr Tyr Val Asp 
            180                 185                 190         


Ala Gly Tyr Glu Val Asp Lys Ile Ala Gln Asn Leu Asp Phe Val Asn 
        195                 200                 205             


Leu Met Ala Tyr Asp Phe His Gly Ser Trp Glu Lys Val Thr Gly His 
    210                 215                 220                 


Asn Ser Pro Leu Tyr Lys Arg Gln Glu Glu Ser Gly Ala Ala Ala Ser 
225                 230                 235                 240 


Leu Asn Val Asp Ala Ala Val Gln Gln Trp Leu Gln Lys Gly Thr Pro 
                245                 250                 255     


Ala Ser Lys Leu Ile Leu Gly Met Pro Thr Tyr Gly Arg Ser Phe Thr 
            260                 265                 270         


Leu Ala Ser Ser Ser Asp Thr Arg Val Gly Ala Pro Ala Thr Gly Ser 
        275                 280                 285             


Gly Thr Pro Gly Pro Phe Thr Lys Glu Gly Gly Met Leu Ala Tyr Tyr 
    290                 295                 300                 


Glu Val Cys Ser Trp Lys Gly Ala Thr Lys Gln Arg Ile Gln Asp Gln 
305                 310                 315                 320 


Lys Val Pro Tyr Ile Phe Arg Asp Asn Gln Trp Val Gly Phe Asp Asp 
                325                 330                 335     


Val Glu Ser Phe Lys Thr Lys Val Ser Tyr Leu Lys Gln Lys Gly Leu 
            340                 345                 350         


Gly Gly Ala Met Val Trp Ala Leu Asp Leu Asp Asp Phe Ala Gly Phe 
        355                 360                 365             


Ser Cys Asn Gln Gly Arg Tyr Pro Leu Ile Gln Thr Leu Arg Gln Glu 
    370                 375                 380                 


Leu Ser Leu Pro Tyr Leu Pro Ser Gly Thr Pro Glu Leu Glu Val Pro 
385                 390                 395                 400 


Lys Pro Gly Gln Pro Ser Glu Pro Glu His Gly Pro Ser Pro Gly Gln 
                405                 410                 415     


Asp Thr Phe Cys Gln Gly Lys Ala Asp Gly Leu Tyr Pro Asn Pro Arg 
            420                 425                 430         


Glu Arg Ser Ser Phe Tyr Ser Cys Ala Ala Gly Arg Leu Phe Gln Gln 
        435                 440                 445             


Ser Cys Pro Thr Gly Leu Val Phe Ser Asn Ser Cys Lys Cys Cys Thr 
    450                 455                 460                 


Trp Asn 
465     


<210>  2814
<211>  387
<212>  PRT
<213>  Homo Sapiens

<400>  2814

Met Val Arg Ser Val Ala Trp Ala Gly Phe Met Val Leu Leu Met Ile 
1               5                   10                  15      


Pro Trp Gly Ser Ala Ala Lys Leu Val Cys Tyr Phe Thr Asn Trp Ala 
            20                  25                  30          


Gln Tyr Arg Gln Gly Glu Ala Arg Phe Leu Pro Lys Asp Leu Asp Pro 
        35                  40                  45              


Ser Leu Cys Thr His Leu Ile Tyr Ala Phe Ala Gly Met Thr Asn His 
    50                  55                  60                  


Gln Leu Ser Thr Thr Glu Trp Asn Asp Glu Thr Leu Tyr Gln Glu Phe 
65                  70                  75                  80  


Asn Gly Leu Lys Lys Met Asn Pro Lys Leu Lys Thr Leu Leu Ala Ile 
                85                  90                  95      


Gly Gly Trp Asn Phe Gly Thr Gln Lys Phe Thr Asp Met Val Ala Thr 
            100                 105                 110         


Ala Asn Asn Arg Gln Thr Phe Val Asn Ser Ala Ile Arg Phe Leu Arg 
        115                 120                 125             


Lys Tyr Ser Phe Asp Gly Leu Asp Leu Asp Trp Glu Tyr Pro Gly Ser 
    130                 135                 140                 


Gln Gly Ser Pro Ala Val Asp Lys Glu Arg Phe Thr Thr Leu Val Gln 
145                 150                 155                 160 


Asp Leu Ala Asn Ala Phe Gln Gln Glu Ala Gln Thr Ser Gly Lys Glu 
                165                 170                 175     


Arg Leu Leu Leu Ser Ala Ala Val Pro Ala Gly Gln Thr Tyr Val Asp 
            180                 185                 190         


Ala Gly Tyr Glu Val Asp Lys Ile Ala Gln Asn Leu Asp Phe Val Asn 
        195                 200                 205             


Leu Met Ala Tyr Asp Phe His Gly Ser Trp Glu Lys Val Thr Gly His 
    210                 215                 220                 


Asn Ser Pro Leu Tyr Lys Arg Gln Glu Glu Ser Gly Ala Ala Ala Ser 
225                 230                 235                 240 


Leu Asn Val Asp Ala Ala Val Gln Gln Trp Leu Gln Lys Gly Thr Pro 
                245                 250                 255     


Ala Ser Lys Leu Ile Leu Gly Met Pro Thr Tyr Gly Arg Ser Phe Thr 
            260                 265                 270         


Leu Ala Ser Ser Ser Asp Thr Arg Val Gly Ala Pro Ala Thr Gly Ser 
        275                 280                 285             


Gly Thr Pro Gly Pro Phe Thr Lys Glu Gly Gly Met Leu Ala Tyr Tyr 
    290                 295                 300                 


Glu Val Cys Ser Trp Lys Gly Ala Thr Lys Gln Arg Ile Gln Asp Gln 
305                 310                 315                 320 


Lys Val Pro Tyr Ile Phe Arg Asp Asn Gln Trp Val Gly Phe Asp Asp 
                325                 330                 335     


Val Glu Ser Phe Lys Thr Lys Val Ser Tyr Leu Lys Gln Lys Gly Leu 
            340                 345                 350         


Gly Gly Ala Met Val Trp Ala Leu Asp Leu Asp Asp Phe Ala Gly Phe 
        355                 360                 365             


Ser Cys Asn Gln Gly Arg Tyr Pro Leu Ile Gln Thr Leu Arg Gln Glu 
    370                 375                 380                 


Leu Asn Gly 
385         


<210>  2815
<211>  361
<212>  PRT
<213>  Homo Sapiens

<400>  2815

Met Val Arg Ser Val Ala Trp Ala Gly Phe Met Val Leu Leu Met Ile 
1               5                   10                  15      


Pro Trp Gly Ser Ala Ala Lys Leu Val Cys Tyr Phe Thr Asn Trp Ala 
            20                  25                  30          


Gln Tyr Arg Gln Gly Glu Ala Arg Phe Leu Pro Lys Asp Leu Asp Pro 
        35                  40                  45              


Ser Leu Cys Thr His Leu Ile Tyr Ala Phe Ala Gly Met Thr Asn His 
    50                  55                  60                  


Gln Leu Ser Thr Thr Glu Trp Asn Asp Glu Thr Leu Tyr Gln Glu Phe 
65                  70                  75                  80  


Asn Gly Leu Lys Lys Met Asn Pro Lys Leu Lys Thr Leu Leu Ala Ile 
                85                  90                  95      


Gly Gly Trp Asn Phe Gly Thr Gln Lys Phe Thr Asp Met Val Ala Thr 
            100                 105                 110         


Ala Asn Asn Arg Gln Thr Phe Val Asn Ser Ala Ile Arg Phe Leu Arg 
        115                 120                 125             


Lys Tyr Ser Phe Asp Gly Leu Asp Leu Asp Trp Glu Tyr Pro Gly Ser 
    130                 135                 140                 


Gln Gly Ser Pro Ala Val Asp Lys Glu Arg Phe Thr Thr Leu Val Gln 
145                 150                 155                 160 


Asp Leu Ala Asn Ala Phe Gln Gln Glu Ala Gln Thr Ser Gly Lys Glu 
                165                 170                 175     


Arg Leu Leu Leu Ser Ala Ala Val Pro Ala Gly Gln Thr Tyr Val Asp 
            180                 185                 190         


Ala Gly Tyr Glu Val Asp Lys Ile Ala Gln Asn Leu Asp Phe Val Asn 
        195                 200                 205             


Leu Met Ala Tyr Asp Phe His Gly Ser Trp Glu Lys Val Thr Gly His 
    210                 215                 220                 


Asn Ser Pro Leu Tyr Lys Arg Gln Glu Glu Ser Gly Ala Ala Ala Ser 
225                 230                 235                 240 


Leu Asn Val Asp Ala Ala Val Gln Gln Trp Leu Gln Lys Gly Thr Pro 
                245                 250                 255     


Ala Ser Lys Leu Ile Leu Gly Met Pro Thr Tyr Gly Arg Ser Phe Thr 
            260                 265                 270         


Leu Ala Ser Ser Ser Asp Thr Arg Val Gly Ala Pro Ala Thr Gly Ser 
        275                 280                 285             


Gly Thr Pro Gly Pro Phe Thr Lys Glu Gly Gly Met Leu Ala Tyr Tyr 
    290                 295                 300                 


Glu Val Cys Ser Trp Lys Gly Ala Thr Lys Gln Arg Ile Gln Asp Gln 
305                 310                 315                 320 


Lys Val Pro Tyr Ile Phe Arg Asp Asn Gln Trp Val Gly Phe Asp Asp 
                325                 330                 335     


Val Glu Ser Phe Lys Thr Lys Val Met Leu Thr Leu Arg Gln Gly Asp 
            340                 345                 350         


Cys Lys Met Thr Asp Val Gln Ala Ala 
        355                 360     


<210>  2816
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  2816

Met Glu Pro Leu Leu Leu Gly Arg Gly Leu Ile Val Tyr Leu Met Phe 
1               5                   10                  15      


Leu Leu Leu Lys Phe Ser Lys Ala Ile Glu Ile Pro Ser Ser Val Gln 
            20                  25                  30          


Gln Val Pro Thr Ile Ile Lys Gln Ser Lys Val Gln Val Ala Phe Pro 
        35                  40                  45              


Phe Asp Glu Tyr Phe Gln Ile Glu Cys Glu Ala Lys Gly Asn Pro Glu 
    50                  55                  60                  


Pro Thr 
65      


<210>  2817
<211>  85
<212>  PRT
<213>  Homo Sapiens

<400>  2817

Met Glu Pro Leu Leu Leu Gly Arg Gly Leu Ile Val Tyr Leu Met Phe 
1               5                   10                  15      


Leu Leu Leu Lys Phe Ser Lys Ala Ile Glu Ile Pro Ser Ser Val Gln 
            20                  25                  30          


Gln Val Pro Thr Ile Ile Lys Gln Ser Lys Val Gln Val Ala Phe Pro 
        35                  40                  45              


Phe Asp Glu Tyr Phe Gln Ile Glu Cys Glu Ala Lys Gly Asn Pro Glu 
    50                  55                  60                  


Pro Thr Phe Ser Trp Thr Lys Asp Gly Asn Pro Phe Tyr Phe Thr Asp 
65                  70                  75                  80  


His Arg Ile Ile Pro 
                85  


<210>  2818
<211>  96
<212>  PRT
<213>  Homo Sapiens

<400>  2818

Met Glu Pro Leu Leu Leu Gly Arg Gly Leu Ile Val Tyr Leu Met Phe 
1               5                   10                  15      


Leu Leu Leu Lys Phe Ser Lys Ala Ile Glu Ile Pro Ser Ser Val Gln 
            20                  25                  30          


Gln Val Pro Thr Ile Ile Lys Gln Ser Lys Val Gln Val Ala Phe Pro 
        35                  40                  45              


Phe Asp Glu Tyr Phe Gln Ile Glu Cys Glu Ala Lys Gly Asn Pro Glu 
    50                  55                  60                  


Pro Thr Phe Ser Trp Thr Lys Asp Gly Asn Pro Phe Tyr Phe Thr Asp 
65                  70                  75                  80  


His Arg Ile Ile Pro Ser Asn Asn Ser Gly Thr Phe Arg Ile Pro Asn 
                85                  90                  95      


<210>  2819
<211>  181
<212>  PRT
<213>  Homo Sapiens

<400>  2819

Met Glu Pro Leu Leu Leu Gly Arg Gly Leu Ile Val Tyr Leu Met Phe 
1               5                   10                  15      


Leu Leu Leu Lys Phe Ser Lys Ala Ile Glu Ile Pro Ser Ser Val Gln 
            20                  25                  30          


Gln Val Pro Thr Ile Ile Lys Gln Ser Lys Val Gln Val Ala Phe Pro 
        35                  40                  45              


Phe Asp Glu Tyr Phe Gln Ile Glu Cys Glu Ala Lys Gly Asn Pro Glu 
    50                  55                  60                  


Pro Thr Phe Ser Trp Thr Lys Asp Gly Asn Pro Phe Tyr Phe Thr Asp 
65                  70                  75                  80  


His Arg Ile Ile Pro Ser Asn Asn Ser Gly Thr Phe Arg Ile Pro Asn 
                85                  90                  95      


Glu Gly His Ile Ser His Phe Gln Gly Lys Tyr Arg Cys Phe Ala Ser 
            100                 105                 110         


Asn Lys Leu Gly Ile Ala Met Ser Glu Glu Ile Glu Phe Ile Val Pro 
        115                 120                 125             


Ser Val Pro Lys Phe Pro Lys Glu Lys Ile Asp Pro Leu Glu Val Glu 
    130                 135                 140                 


Glu Gly Asp Pro Ile Val Leu Pro Cys Asn Pro Pro Lys Gly Leu Pro 
145                 150                 155                 160 


Pro Leu His Ile Tyr Trp Met Asn Ile Glu Leu Glu His Ile Glu Gln 
                165                 170                 175     


Asp Glu Arg Val Tyr 
            180     


<210>  2820
<211>  1224
<212>  PRT
<213>  Homo Sapiens

<400>  2820

Met Glu Pro Leu Leu Leu Gly Arg Gly Leu Ile Val Tyr Leu Met Phe 
1               5                   10                  15      


Leu Leu Leu Lys Phe Ser Lys Ala Ile Glu Ile Pro Ser Ser Val Gln 
            20                  25                  30          


Gln Val Pro Thr Ile Ile Lys Gln Ser Lys Val Gln Val Ala Phe Pro 
        35                  40                  45              


Phe Asp Glu Tyr Phe Gln Ile Glu Cys Glu Ala Lys Gly Asn Pro Glu 
    50                  55                  60                  


Pro Thr Phe Ser Trp Thr Lys Asp Gly Asn Pro Phe Tyr Phe Thr Asp 
65                  70                  75                  80  


His Arg Ile Ile Pro Ser Asn Asn Ser Gly Thr Phe Arg Ile Pro Asn 
                85                  90                  95      


Glu Gly His Ile Ser His Phe Gln Gly Lys Tyr Arg Cys Phe Ala Ser 
            100                 105                 110         


Asn Lys Leu Gly Ile Ala Met Ser Glu Glu Ile Glu Phe Ile Val Pro 
        115                 120                 125             


Ser Val Pro Lys Phe Pro Lys Glu Lys Ile Asp Pro Leu Glu Val Glu 
    130                 135                 140                 


Glu Gly Asp Pro Ile Val Leu Pro Cys Asn Pro Pro Lys Gly Leu Pro 
145                 150                 155                 160 


Pro Leu His Ile Tyr Trp Met Asn Ile Glu Leu Glu His Ile Glu Gln 
                165                 170                 175     


Asp Glu Arg Val Tyr Met Ser Gln Lys Gly Asp Leu Tyr Phe Ala Asn 
            180                 185                 190         


Val Glu Glu Lys Asp Ser Arg Asn Asp Tyr Cys Cys Phe Ala Ala Phe 
        195                 200                 205             


Pro Arg Leu Arg Thr Ile Val Gln Lys Met Pro Met Lys Leu Thr Val 
    210                 215                 220                 


Asn Ser Leu Lys His Ala Asn Asp Ser Ser Ser Ser Thr Glu Ile Gly 
225                 230                 235                 240 


Ser Lys Ala Asn Ser Ile Lys Gln Arg Lys Pro Lys Leu Leu Leu Pro 
                245                 250                 255     


Pro Thr Glu Ser Gly Ser Glu Ser Ser Ile Thr Ile Leu Lys Gly Glu 
            260                 265                 270         


Ile Leu Leu Leu Glu Cys Phe Ala Glu Gly Leu Pro Thr Pro Gln Val 
        275                 280                 285             


Asp Trp Asn Lys Ile Gly Gly Asp Leu Pro Lys Gly Arg Glu Thr Lys 
    290                 295                 300                 


Glu Asn Tyr Gly Lys Thr Leu Lys Ile Glu Asn Val Ser Tyr Gln Asp 
305                 310                 315                 320 


Lys Gly Asn Tyr Arg Cys Thr Ala Ser Asn Phe Leu Gly Thr Ala Thr 
                325                 330                 335     


His Asp Phe His Val Ile Val Glu Glu Pro Pro Arg Trp Thr Lys Lys 
            340                 345                 350         


Pro Gln Ser Ala Val Tyr Ser Thr Gly Ser Asn Gly Ile Leu Leu Cys 
        355                 360                 365             


Glu Ala Glu Gly Glu Pro Gln Pro Thr Ile Lys Trp Arg Val Asn Gly 
    370                 375                 380                 


Ser Pro Val Asp Asn His Pro Phe Ala Gly Asp Val Val Phe Pro Arg 
385                 390                 395                 400 


Glu Ile Ser Phe Thr Asn Leu Gln Pro Asn His Thr Ala Val Tyr Gln 
                405                 410                 415     


Cys Glu Ala Ser Asn Val His Gly Thr Ile Leu Ala Asn Ala Asn Ile 
            420                 425                 430         


Asp Val Val Asp Val Arg Pro Leu Ile Gln Thr Lys Asp Gly Glu Asn 
        435                 440                 445             


Tyr Ala Thr Val Val Gly Tyr Ser Ala Phe Leu His Cys Glu Phe Phe 
    450                 455                 460                 


Ala Ser Pro Glu Ala Val Val Ser Trp Gln Lys Val Glu Glu Val Lys 
465                 470                 475                 480 


Pro Leu Glu Gly Arg Arg Tyr His Ile Tyr Glu Asn Gly Thr Leu Gln 
                485                 490                 495     


Ile Asn Arg Thr Thr Glu Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val 
            500                 505                 510         


Glu Asn Ala Ile Gly Lys Thr Ala Val Thr Ala Asn Leu Asp Ile Arg 
        515                 520                 525             


Asn Ala Thr Lys Leu Arg Val Ser Pro Lys Asn Pro Arg Ile Pro Lys 
    530                 535                 540                 


Leu His Met Leu Glu Leu His Cys Glu Ser Lys Cys Asp Ser His Leu 
545                 550                 555                 560 


Lys His Ser Leu Lys Leu Ser Trp Ser Lys Asp Gly Glu Ala Phe Glu 
                565                 570                 575     


Ile Asn Gly Thr Glu Asp Gly Arg Ile Ile Ile Asp Gly Ala Asn Leu 
            580                 585                 590         


Thr Ile Ser Asn Val Thr Leu Glu Asp Gln Gly Ile Tyr Cys Cys Ser 
        595                 600                 605             


Ala His Thr Ala Leu Asp Ser Ala Ala Asp Ile Thr Gln Val Thr Val 
    610                 615                 620                 


Leu Asp Val Pro Asp Pro Pro Glu Asn Leu His Leu Ser Glu Arg Gln 
625                 630                 635                 640 


Asn Arg Ser Val Arg Leu Thr Trp Glu Ala Gly Ala Asp His Asn Ser 
                645                 650                 655     


Asn Ile Ser Glu Tyr Ile Val Glu Phe Glu Gly Asn Lys Glu Glu Pro 
            660                 665                 670         


Gly Arg Trp Glu Glu Leu Thr Arg Val Gln Gly Lys Lys Thr Thr Val 
        675                 680                 685             


Ile Leu Pro Leu Ala Pro Phe Val Arg Tyr Gln Phe Arg Val Ile Ala 
    690                 695                 700                 


Val Asn Glu Val Gly Arg Ser Gln Pro Ser Gln Pro Ser Asp His His 
705                 710                 715                 720 


Glu Thr Pro Pro Ala Ala Pro Asp Arg Asn Pro Gln Asn Ile Arg Val 
                725                 730                 735     


Gln Ala Ser Gln Pro Lys Glu Met Ile Ile Lys Trp Glu Pro Leu Lys 
            740                 745                 750         


Ser Met Glu Gln Asn Gly Pro Gly Leu Glu Tyr Arg Val Thr Trp Lys 
        755                 760                 765             


Pro Gln Gly Ala Pro Val Glu Trp Glu Glu Glu Thr Val Thr Asn His 
    770                 775                 780                 


Thr Leu Arg Val Met Thr Pro Ala Val Tyr Ala Pro Tyr Asp Val Lys 
785                 790                 795                 800 


Val Gln Ala Ile Asn Gln Leu Gly Ser Gly Pro Asp Pro Gln Ser Val 
                805                 810                 815     


Thr Leu Tyr Ser Gly Glu Asp Tyr Pro Asp Thr Ala Pro Val Ile His 
            820                 825                 830         


Gly Val Asp Val Ile Asn Ser Thr Leu Val Lys Val Thr Trp Ser Thr 
        835                 840                 845             


Val Pro Lys Asp Arg Val His Gly Arg Leu Lys Gly Tyr Gln Ile Asn 
    850                 855                 860                 


Trp Trp Lys Thr Lys Ser Leu Leu Asp Gly Arg Thr His Pro Lys Glu 
865                 870                 875                 880 


Val Asn Ile Leu Arg Phe Ser Gly Gln Arg Asn Ser Gly Met Val Pro 
                885                 890                 895     


Ser Leu Asp Ala Phe Ser Glu Phe His Leu Thr Val Leu Ala Tyr Asn 
            900                 905                 910         


Ser Lys Gly Ala Gly Pro Glu Ser Glu Pro Tyr Ile Phe Gln Thr Pro 
        915                 920                 925             


Glu Gly Val Pro Glu Gln Pro Thr Phe Leu Lys Val Ile Lys Val Asp 
    930                 935                 940                 


Lys Asp Thr Ala Thr Leu Ser Trp Gly Leu Pro Lys Lys Leu Asn Gly 
945                 950                 955                 960 


Asn Leu Thr Gly Tyr Leu Leu Gln Tyr Gln Ile Ile Asn Asp Thr Tyr 
                965                 970                 975     


Glu Ile Gly Glu Leu Asn Asp Ile Asn Ile Thr Thr Pro Ser Lys Pro 
            980                 985                 990         


Ser Trp His Leu Ser Asn Leu Asn  Ala Thr Thr Lys Tyr  Lys Phe Tyr 
        995                 1000                 1005             


Leu Arg  Ala Cys Thr Ser Gln  Gly Cys Gly Lys Pro  Ile Thr Glu 
    1010                 1015                 1020             


Glu Ser  Ser Thr Leu Gly Glu  Gly Ser Lys Gly Ile  Gly Lys Ile 
    1025                 1030                 1035             


Ser Gly  Val Asn Leu Thr Gln  Lys Thr His Pro Ile  Glu Val Phe 
    1040                 1045                 1050             


Glu Pro  Gly Ala Glu His Ile  Val Arg Leu Met Thr  Lys Asn Trp 
    1055                 1060                 1065             


Gly Asp  Asn Asp Ser Ile Phe  Gln Asp Val Ile Glu  Thr Arg Gly 
    1070                 1075                 1080             


Arg Glu  Tyr Ala Gly Leu Tyr  Asp Asp Ile Ser Thr  Gln Gly Trp 
    1085                 1090                 1095             


Phe Ile  Gly Leu Met Cys Ala  Ile Ala Leu Leu Thr  Leu Leu Leu 
    1100                 1105                 1110             


Leu Thr  Val Cys Phe Val Lys  Arg Asn Arg Gly Gly  Lys Tyr Ser 
    1115                 1120                 1125             


Val Lys  Glu Lys Glu Asp Leu  His Pro Asp Pro Glu  Ile Gln Ser 
    1130                 1135                 1140             


Val Lys  Asp Glu Thr Phe Gly  Glu Tyr Ser Asp Ser  Asp Glu Lys 
    1145                 1150                 1155             


Pro Leu  Lys Gly Ser Leu Arg  Ser Leu Asn Arg Asp  Met Gln Pro 
    1160                 1165                 1170             


Thr Glu  Ser Ala Asp Ser Leu  Val Glu Tyr Gly Glu  Gly Asp His 
    1175                 1180                 1185             


Gly Leu  Phe Ser Glu Asp Gly  Ser Phe Ile Gly Ala  Tyr Ala Gly 
    1190                 1195                 1200             


Ser Lys  Glu Lys Gly Ser Val  Glu Ser Asn Gly Ser  Ser Thr Ala 
    1205                 1210                 1215             


Thr Phe  Pro Leu Arg Ala 
    1220                 


<210>  2821
<211>  1171
<212>  PRT
<213>  Homo Sapiens

<400>  2821

Met Glu Pro Leu Leu Leu Gly Arg Gly Leu Ile Val Tyr Leu Met Phe 
1               5                   10                  15      


Leu Leu Leu Lys Phe Ser Lys Ala Ile Glu Ile Pro Ser Ser Val Gln 
            20                  25                  30          


Gln Val Pro Thr Ile Ile Lys Gln Ser Lys Val Gln Val Ala Phe Pro 
        35                  40                  45              


Phe Asp Glu Tyr Phe Gln Ile Glu Cys Glu Ala Lys Gly Asn Pro Glu 
    50                  55                  60                  


Pro Thr Phe Ser Trp Thr Lys Asp Gly Asn Pro Phe Tyr Phe Thr Asp 
65                  70                  75                  80  


His Arg Ile Ile Pro Ser Asn Asn Ser Gly Thr Phe Arg Ile Pro Asn 
                85                  90                  95      


Glu Gly His Ile Ser His Phe Gln Gly Lys Tyr Arg Cys Phe Ala Ser 
            100                 105                 110         


Asn Lys Leu Gly Ile Ala Met Ser Glu Glu Ile Glu Phe Ile Val Pro 
        115                 120                 125             


Ser Val Pro Lys Phe Pro Lys Glu Lys Ile Asp Pro Leu Glu Val Glu 
    130                 135                 140                 


Glu Gly Asp Pro Ile Val Leu Pro Cys Asn Pro Pro Lys Gly Leu Pro 
145                 150                 155                 160 


Pro Leu His Ile Tyr Trp Met Asn Ile Glu Leu Glu His Ile Glu Gln 
                165                 170                 175     


Asp Glu Arg Val Tyr Met Ser Gln Lys Gly Asp Leu Tyr Phe Ala Asn 
            180                 185                 190         


Val Glu Glu Lys Asp Ser Arg Asn Asp Tyr Cys Cys Phe Ala Ala Phe 
        195                 200                 205             


Pro Arg Leu Arg Thr Ile Val Gln Lys Met Pro Met Lys Leu Thr Val 
    210                 215                 220                 


Asn Ser Leu Lys His Ala Asn Asp Ser Ser Ser Ser Thr Glu Ile Gly 
225                 230                 235                 240 


Ser Lys Ala Asn Ser Ile Lys Gln Arg Lys Pro Lys Leu Leu Leu Pro 
                245                 250                 255     


Pro Thr Glu Ser Gly Ser Glu Ser Ser Ile Thr Ile Leu Lys Gly Glu 
            260                 265                 270         


Ile Leu Leu Leu Glu Cys Phe Ala Glu Gly Leu Pro Thr Pro Gln Val 
        275                 280                 285             


Asp Trp Asn Lys Ile Gly Gly Asp Leu Pro Lys Gly Arg Glu Thr Lys 
    290                 295                 300                 


Glu Asn Tyr Gly Lys Thr Leu Lys Ile Glu Asn Val Ser Tyr Gln Asp 
305                 310                 315                 320 


Lys Gly Asn Tyr Arg Cys Thr Ala Ser Asn Phe Leu Gly Thr Ala Thr 
                325                 330                 335     


His Asp Phe His Val Ile Val Glu Glu Pro Pro Arg Trp Thr Lys Lys 
            340                 345                 350         


Pro Gln Ser Ala Val Tyr Ser Thr Gly Ser Asn Gly Ile Leu Leu Cys 
        355                 360                 365             


Glu Ala Glu Gly Glu Pro Gln Pro Thr Ile Lys Trp Arg Val Asn Gly 
    370                 375                 380                 


Ser Pro Val Asp Asn His Pro Phe Ala Gly Asp Val Val Phe Pro Arg 
385                 390                 395                 400 


Glu Ile Ser Phe Thr Asn Leu Gln Pro Asn His Thr Ala Val Tyr Gln 
                405                 410                 415     


Cys Glu Ala Ser Asn Val His Gly Thr Ile Leu Ala Asn Ala Asn Ile 
            420                 425                 430         


Asp Val Val Asp Val Arg Pro Leu Ile Gln Thr Lys Asp Gly Glu Asn 
        435                 440                 445             


Tyr Ala Thr Val Val Gly Tyr Ser Ala Phe Leu His Cys Glu Phe Phe 
    450                 455                 460                 


Ala Ser Pro Glu Ala Val Val Ser Trp Gln Lys Val Glu Glu Val Lys 
465                 470                 475                 480 


Pro Leu Glu Gly Arg Arg Tyr His Ile Tyr Glu Asn Gly Thr Leu Gln 
                485                 490                 495     


Ile Asn Arg Thr Thr Glu Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val 
            500                 505                 510         


Glu Asn Ala Ile Gly Lys Thr Ala Val Thr Ala Asn Leu Asp Ile Arg 
        515                 520                 525             


Asn Ala Thr Lys Leu Arg Val Ser Pro Lys Asn Pro Arg Ile Pro Lys 
    530                 535                 540                 


Leu His Met Leu Glu Leu His Cys Glu Ser Lys Cys Asp Ser His Leu 
545                 550                 555                 560 


Lys His Ser Leu Lys Leu Ser Trp Ser Lys Asp Gly Glu Ala Phe Glu 
                565                 570                 575     


Ile Asn Gly Thr Glu Asp Gly Arg Ile Ile Ile Asp Gly Ala Asn Leu 
            580                 585                 590         


Thr Ile Ser Asn Val Thr Leu Glu Asp Gln Gly Ile Tyr Cys Cys Ser 
        595                 600                 605             


Ala His Thr Ala Leu Asp Ser Ala Ala Asp Ile Thr Gln Val Thr Val 
    610                 615                 620                 


Leu Asp Val Pro Asp Pro Pro Glu Asn Leu His Leu Ser Glu Arg Gln 
625                 630                 635                 640 


Asn Arg Ser Val Arg Leu Thr Trp Glu Ala Gly Ala Asp His Asn Ser 
                645                 650                 655     


Asn Ile Ser Glu Tyr Ile Val Glu Phe Glu Gly Asn Lys Glu Glu Pro 
            660                 665                 670         


Gly Arg Trp Glu Glu Leu Thr Arg Val Gln Gly Lys Lys Thr Thr Val 
        675                 680                 685             


Ile Leu Pro Leu Ala Pro Phe Val Arg Tyr Gln Phe Arg Val Ile Ala 
    690                 695                 700                 


Val Asn Glu Val Gly Arg Ser Gln Pro Ser Gln Pro Ser Asp His His 
705                 710                 715                 720 


Glu Thr Pro Pro Ala Ala Pro Asp Arg Asn Pro Gln Asn Ile Arg Val 
                725                 730                 735     


Gln Ala Ser Gln Pro Lys Glu Met Ile Ile Lys Trp Glu Pro Leu Lys 
            740                 745                 750         


Ser Met Glu Gln Asn Gly Pro Gly Leu Glu Tyr Arg Val Thr Trp Lys 
        755                 760                 765             


Pro Gln Gly Ala Pro Val Glu Trp Glu Glu Glu Thr Val Thr Asn His 
    770                 775                 780                 


Thr Leu Arg Val Met Thr Pro Ala Val Tyr Ala Pro Tyr Asp Val Lys 
785                 790                 795                 800 


Val Gln Ala Ile Asn Gln Leu Gly Ser Gly Pro Asp Pro Gln Ser Val 
                805                 810                 815     


Thr Leu Tyr Ser Gly Glu Asp Tyr Pro Asp Thr Ala Pro Val Ile His 
            820                 825                 830         


Gly Val Asp Val Ile Asn Ser Thr Leu Val Lys Val Thr Trp Ser Thr 
        835                 840                 845             


Val Pro Lys Asp Arg Val His Gly Arg Leu Lys Gly Tyr Gln Ile Asn 
    850                 855                 860                 


Trp Trp Lys Thr Lys Ser Leu Leu Asp Gly Arg Thr His Pro Lys Glu 
865                 870                 875                 880 


Val Asn Ile Leu Arg Phe Ser Gly Gln Arg Asn Ser Gly Met Val Pro 
                885                 890                 895     


Ser Leu Asp Ala Phe Ser Glu Phe His Leu Thr Val Leu Ala Tyr Asn 
            900                 905                 910         


Ser Lys Gly Ala Gly Pro Glu Ser Glu Pro Tyr Ile Phe Gln Thr Pro 
        915                 920                 925             


Glu Gly Val Pro Glu Gln Pro Thr Phe Leu Lys Val Ile Lys Val Asp 
    930                 935                 940                 


Lys Asp Thr Ala Thr Leu Ser Trp Gly Leu Pro Lys Lys Leu Asn Gly 
945                 950                 955                 960 


Asn Leu Thr Gly Tyr Leu Leu Gln Tyr Gln Ile Ile Asn Asp Thr Tyr 
                965                 970                 975     


Glu Ile Gly Glu Leu Asn Asp Ile Asn Ile Thr Thr Pro Ser Lys Pro 
            980                 985                 990         


Ser Trp His Leu Ser Asn Leu Asn  Ala Thr Thr Lys Tyr  Lys Phe Tyr 
        995                 1000                 1005             


Leu Arg  Ala Cys Thr Ser Gln  Gly Cys Gly Lys Pro  Ile Thr Glu 
    1010                 1015                 1020             


Glu Ser  Ser Thr Leu Gly Glu  Gly Lys Tyr Ala Gly  Leu Tyr Asp 
    1025                 1030                 1035             


Asp Ile  Ser Thr Gln Gly Trp  Phe Ile Gly Leu Met  Cys Ala Ile 
    1040                 1045                 1050             


Ala Leu  Leu Thr Leu Leu Leu  Leu Thr Val Cys Phe  Val Lys Arg 
    1055                 1060                 1065             


Asn Arg  Gly Gly Lys Tyr Ser  Val Lys Glu Lys Glu  Asp Leu His 
    1070                 1075                 1080             


Pro Asp  Pro Glu Ile Gln Ser  Val Lys Asp Glu Thr  Phe Gly Glu 
    1085                 1090                 1095             


Tyr Ser  Asp Ser Asp Glu Lys  Pro Leu Lys Gly Ser  Leu Arg Ser 
    1100                 1105                 1110             


Leu Asn  Arg Asp Met Gln Pro  Thr Glu Ser Ala Asp  Ser Leu Val 
    1115                 1120                 1125             


Glu Tyr  Gly Glu Gly Asp His  Gly Leu Phe Ser Glu  Asp Gly Ser 
    1130                 1135                 1140             


Phe Ile  Gly Ala Tyr Ala Gly  Ser Lys Glu Lys Gly  Ser Val Glu 
    1145                 1150                 1155             


Ser Asn  Gly Ser Ser Thr Ala  Thr Phe Pro Leu Arg  Ala 
    1160                 1165                 1170     


<210>  2822
<211>  1208
<212>  PRT
<213>  Homo Sapiens

<400>  2822

Met Glu Pro Leu Leu Leu Gly Arg Gly Leu Ile Val Tyr Leu Met Phe 
1               5                   10                  15      


Leu Leu Leu Lys Phe Ser Lys Ala Ile Glu Ile Pro Ser Ser Val Gln 
            20                  25                  30          


Gln Val Pro Thr Ile Ile Lys Gln Ser Lys Val Gln Val Ala Phe Pro 
        35                  40                  45              


Phe Asp Glu Tyr Phe Gln Ile Glu Cys Glu Ala Lys Gly Asn Pro Glu 
    50                  55                  60                  


Pro Thr Phe Ser Trp Thr Lys Asp Gly Asn Pro Phe Tyr Phe Thr Asp 
65                  70                  75                  80  


His Arg Ile Ile Pro Ser Asn Asn Ser Gly Thr Phe Arg Ile Pro Asn 
                85                  90                  95      


Glu Gly His Ile Ser His Phe Gln Gly Lys Tyr Arg Cys Phe Ala Ser 
            100                 105                 110         


Asn Lys Leu Gly Ile Ala Met Ser Glu Glu Ile Glu Phe Ile Val Pro 
        115                 120                 125             


Ser Val Pro Lys Phe Pro Lys Glu Lys Ile Asp Pro Leu Glu Val Glu 
    130                 135                 140                 


Glu Gly Asp Pro Ile Val Leu Pro Cys Asn Pro Pro Lys Gly Leu Pro 
145                 150                 155                 160 


Pro Leu His Ile Tyr Trp Met Asn Ile Glu Leu Glu His Ile Glu Gln 
                165                 170                 175     


Asp Glu Arg Val Tyr Met Ser Gln Lys Gly Asp Leu Tyr Phe Ala Asn 
            180                 185                 190         


Val Glu Glu Lys Asp Ser Arg Asn Asp Tyr Cys Cys Phe Ala Ala Phe 
        195                 200                 205             


Pro Arg Leu Arg Thr Ile Val Gln Lys Met Pro Met Lys Leu Thr Val 
    210                 215                 220                 


Asn Ser Ser Asn Ser Ile Lys Gln Arg Lys Pro Lys Leu Leu Leu Pro 
225                 230                 235                 240 


Pro Thr Glu Ser Gly Ser Glu Ser Ser Ile Thr Ile Leu Lys Gly Glu 
                245                 250                 255     


Ile Leu Leu Leu Glu Cys Phe Ala Glu Gly Leu Pro Thr Pro Gln Val 
            260                 265                 270         


Asp Trp Asn Lys Ile Gly Gly Asp Leu Pro Lys Gly Arg Glu Thr Lys 
        275                 280                 285             


Glu Asn Tyr Gly Lys Thr Leu Lys Ile Glu Asn Val Ser Tyr Gln Asp 
    290                 295                 300                 


Lys Gly Asn Tyr Arg Cys Thr Ala Ser Asn Phe Leu Gly Thr Ala Thr 
305                 310                 315                 320 


His Asp Phe His Val Ile Val Glu Glu Pro Pro Arg Trp Thr Lys Lys 
                325                 330                 335     


Pro Gln Ser Ala Val Tyr Ser Thr Gly Ser Asn Gly Ile Leu Leu Cys 
            340                 345                 350         


Glu Ala Glu Gly Glu Pro Gln Pro Thr Ile Lys Trp Arg Val Asn Gly 
        355                 360                 365             


Ser Pro Val Asp Asn His Pro Phe Ala Gly Asp Val Val Phe Pro Arg 
    370                 375                 380                 


Glu Ile Ser Phe Thr Asn Leu Gln Pro Asn His Thr Ala Val Tyr Gln 
385                 390                 395                 400 


Cys Glu Ala Ser Asn Val His Gly Thr Ile Leu Ala Asn Ala Asn Ile 
                405                 410                 415     


Asp Val Val Asp Val Arg Pro Leu Ile Gln Thr Lys Asp Gly Glu Asn 
            420                 425                 430         


Tyr Ala Thr Val Val Gly Tyr Ser Ala Phe Leu His Cys Glu Phe Phe 
        435                 440                 445             


Ala Ser Pro Glu Ala Val Val Ser Trp Gln Lys Val Glu Glu Val Lys 
    450                 455                 460                 


Pro Leu Glu Gly Arg Arg Tyr His Ile Tyr Glu Asn Gly Thr Leu Gln 
465                 470                 475                 480 


Ile Asn Arg Thr Thr Glu Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val 
                485                 490                 495     


Glu Asn Ala Ile Gly Lys Thr Ala Val Thr Ala Asn Leu Asp Ile Arg 
            500                 505                 510         


Asn Ala Thr Lys Leu Arg Val Ser Pro Lys Asn Pro Arg Ile Pro Lys 
        515                 520                 525             


Leu His Met Leu Glu Leu His Cys Glu Ser Lys Cys Asp Ser His Leu 
    530                 535                 540                 


Lys His Ser Leu Lys Leu Ser Trp Ser Lys Asp Gly Glu Ala Phe Glu 
545                 550                 555                 560 


Ile Asn Gly Thr Glu Asp Gly Arg Ile Ile Ile Asp Gly Ala Asn Leu 
                565                 570                 575     


Thr Ile Ser Asn Val Thr Leu Glu Asp Gln Gly Ile Tyr Cys Cys Ser 
            580                 585                 590         


Ala His Thr Ala Leu Asp Ser Ala Ala Asp Ile Thr Gln Val Thr Val 
        595                 600                 605             


Leu Asp Val Pro Asp Pro Pro Glu Asn Leu His Leu Ser Glu Arg Gln 
    610                 615                 620                 


Asn Arg Ser Val Arg Leu Thr Trp Glu Ala Gly Ala Asp His Asn Ser 
625                 630                 635                 640 


Asn Ile Ser Glu Tyr Ile Val Glu Phe Glu Gly Asn Lys Glu Glu Pro 
                645                 650                 655     


Gly Arg Trp Glu Glu Leu Thr Arg Val Gln Gly Lys Lys Thr Thr Val 
            660                 665                 670         


Ile Leu Pro Leu Ala Pro Phe Val Arg Tyr Gln Phe Arg Val Ile Ala 
        675                 680                 685             


Val Asn Glu Val Gly Arg Ser Gln Pro Ser Gln Pro Ser Asp His His 
    690                 695                 700                 


Glu Thr Pro Pro Ala Ala Pro Asp Arg Asn Pro Gln Asn Ile Arg Val 
705                 710                 715                 720 


Gln Ala Ser Gln Pro Lys Glu Met Ile Ile Lys Trp Glu Pro Leu Lys 
                725                 730                 735     


Ser Met Glu Gln Asn Gly Pro Gly Leu Glu Tyr Arg Val Thr Trp Lys 
            740                 745                 750         


Pro Gln Gly Ala Pro Val Glu Trp Glu Glu Glu Thr Val Thr Asn His 
        755                 760                 765             


Thr Leu Arg Val Met Thr Pro Ala Val Tyr Ala Pro Tyr Asp Val Lys 
    770                 775                 780                 


Val Gln Ala Ile Asn Gln Leu Gly Ser Gly Pro Asp Pro Gln Ser Val 
785                 790                 795                 800 


Thr Leu Tyr Ser Gly Glu Asp Tyr Pro Asp Thr Ala Pro Val Ile His 
                805                 810                 815     


Gly Val Asp Val Ile Asn Ser Thr Leu Val Lys Val Thr Trp Ser Thr 
            820                 825                 830         


Val Pro Lys Asp Arg Val His Gly Arg Leu Lys Gly Tyr Gln Ile Asn 
        835                 840                 845             


Trp Trp Lys Thr Lys Ser Leu Leu Asp Gly Arg Thr His Pro Lys Glu 
    850                 855                 860                 


Val Asn Ile Leu Arg Phe Ser Gly Gln Arg Asn Ser Gly Met Val Pro 
865                 870                 875                 880 


Ser Leu Asp Ala Phe Ser Glu Phe His Leu Thr Val Leu Ala Tyr Asn 
                885                 890                 895     


Ser Lys Gly Ala Gly Pro Glu Ser Glu Pro Tyr Ile Phe Gln Thr Pro 
            900                 905                 910         


Glu Gly Val Pro Glu Gln Pro Thr Phe Leu Lys Val Ile Lys Val Asp 
        915                 920                 925             


Lys Asp Thr Ala Thr Leu Ser Trp Gly Leu Pro Lys Lys Leu Asn Gly 
    930                 935                 940                 


Asn Leu Thr Gly Tyr Leu Leu Gln Tyr Gln Ile Ile Asn Asp Thr Tyr 
945                 950                 955                 960 


Glu Ile Gly Glu Leu Asn Asp Ile Asn Ile Thr Thr Pro Ser Lys Pro 
                965                 970                 975     


Ser Trp His Leu Ser Asn Leu Asn Ala Thr Thr Lys Tyr Lys Phe Tyr 
            980                 985                 990         


Leu Arg Ala Cys Thr Ser Gln Gly  Cys Gly Lys Pro Ile  Thr Glu Glu 
        995                 1000                 1005             


Ser Ser  Thr Leu Gly Glu Gly  Ser Lys Gly Ile Gly  Lys Ile Ser 
    1010                 1015                 1020             


Gly Val  Asn Leu Thr Gln Lys  Thr His Pro Ile Glu  Val Phe Glu 
    1025                 1030                 1035             


Pro Gly  Ala Glu His Ile Val  Arg Leu Met Thr Lys  Asn Trp Gly 
    1040                 1045                 1050             


Asp Asn  Asp Ser Ile Phe Gln  Asp Val Ile Glu Thr  Arg Gly Arg 
    1055                 1060                 1065             


Glu Tyr  Ala Gly Leu Tyr Asp  Asp Ile Ser Thr Gln  Gly Trp Phe 
    1070                 1075                 1080             


Ile Gly  Leu Met Cys Ala Ile  Ala Leu Leu Thr Leu  Leu Leu Leu 
    1085                 1090                 1095             


Thr Val  Cys Phe Val Lys Arg  Asn Arg Gly Gly Lys  Tyr Ser Val 
    1100                 1105                 1110             


Lys Glu  Lys Glu Asp Leu His  Pro Asp Pro Glu Ile  Gln Ser Val 
    1115                 1120                 1125             


Lys Asp  Glu Thr Phe Gly Glu  Tyr Ser Asp Ser Asp  Glu Lys Pro 
    1130                 1135                 1140             


Leu Lys  Gly Ser Leu Arg Ser  Leu Asn Arg Asp Met  Gln Pro Thr 
    1145                 1150                 1155             


Glu Ser  Ala Asp Ser Leu Val  Glu Tyr Gly Glu Gly  Asp His Gly 
    1160                 1165                 1170             


Leu Phe  Ser Glu Asp Gly Ser  Phe Ile Gly Ala Tyr  Ala Gly Ser 
    1175                 1180                 1185             


Lys Glu  Lys Gly Ser Val Glu  Ser Asn Gly Ser Ser  Thr Ala Thr 
    1190                 1195                 1200             


Phe Pro  Leu Arg Ala 
    1205             


<210>  2823
<211>  93
<212>  PRT
<213>  Homo Sapiens

<400>  2823

Met Pro Pro Ala Trp Ser Gly Glu Ser Met Asp Arg Gly Val Val Gly 
1               5                   10                  15      


Leu Gly Ser Thr Lys Thr Gln Arg Gly Ala Arg Ala Pro Pro Pro Gln 
            20                  25                  30          


Thr Ala Glu Gly Arg Glu Gly Ala Pro Gly Ala Val Val Ala Met Ala 
        35                  40                  45              


Pro Gly Ser Gly Ala Arg Gly Ala Gly Asp Ala Gly Arg Gly Trp Ser 
    50                  55                  60                  


Leu Leu Pro Leu Cys Ala Ser Leu Phe Leu Ser Leu Phe Phe Phe Phe 
65                  70                  75                  80  


Trp Ser Val Ser Val Arg Gly Glu Ala Ala Arg Arg Lys 
                85                  90              


<210>  2824
<211>  358
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2824

Xaa Ser Val Thr Leu Tyr Ser Gly Glu Asp Tyr Pro Asp Thr Ala Pro 
1               5                   10                  15      


Val Ile His Gly Val Asp Val Ile Asn Ser Thr Leu Val Lys Val Thr 
            20                  25                  30          


Trp Ser Thr Val Pro Lys Asp Arg Val His Gly Arg Leu Lys Gly Tyr 
        35                  40                  45              


Gln Ile Asn Trp Trp Lys Thr Lys Ser Leu Leu Asp Gly Arg Thr His 
    50                  55                  60                  


Pro Lys Glu Val Asn Ile Leu Arg Phe Ser Gly Gln Arg Asn Ser Gly 
65                  70                  75                  80  


Met Val Pro Ser Leu Asp Ala Phe Ser Glu Phe His Leu Thr Val Leu 
                85                  90                  95      


Ala Tyr Asn Ser Lys Gly Ala Gly Pro Glu Ser Glu Pro Tyr Ile Phe 
            100                 105                 110         


Gln Thr Pro Glu Gly Val Pro Glu Gln Pro Thr Phe Leu Lys Val Ile 
        115                 120                 125             


Lys Val Asp Lys Asp Thr Ala Thr Leu Ser Trp Gly Leu Pro Lys Lys 
    130                 135                 140                 


Leu Asn Gly Asn Leu Thr Gly Tyr Leu Leu Gln Tyr Gln Ile Ile Asn 
145                 150                 155                 160 


Asp Thr Tyr Glu Ile Gly Glu Leu Asn Asp Ile Asn Ile Thr Thr Pro 
                165                 170                 175     


Ser Lys Pro Ser Trp His Leu Ser Asn Leu Asn Ala Thr Thr Lys Tyr 
            180                 185                 190         


Lys Phe Tyr Leu Arg Ala Cys Thr Ser Gln Gly Cys Gly Lys Pro Ile 
        195                 200                 205             


Thr Glu Glu Ser Ser Thr Leu Gly Glu Gly Lys Tyr Ala Gly Leu Tyr 
    210                 215                 220                 


Asp Asp Ile Ser Thr Gln Gly Trp Phe Ile Gly Leu Met Cys Ala Ile 
225                 230                 235                 240 


Ala Leu Leu Thr Leu Leu Leu Leu Thr Val Cys Phe Val Lys Arg Asn 
                245                 250                 255     


Arg Gly Gly Lys Tyr Ser Val Lys Glu Lys Glu Asp Leu His Pro Asp 
            260                 265                 270         


Pro Glu Ile Gln Ser Val Lys Asp Glu Thr Phe Gly Glu Tyr Ser Asp 
        275                 280                 285             


Ser Asp Glu Lys Pro Leu Lys Gly Ser Leu Arg Ser Leu Asn Arg Asp 
    290                 295                 300                 


Met Gln Pro Thr Glu Ser Ala Asp Ser Leu Val Glu Tyr Gly Glu Gly 
305                 310                 315                 320 


Asp His Gly Leu Phe Ser Glu Asp Gly Ser Phe Ile Gly Ala Tyr Ala 
                325                 330                 335     


Gly Ser Lys Glu Lys Gly Ser Val Glu Ser Asn Gly Ser Ser Thr Ala 
            340                 345                 350         


Thr Phe Pro Leu Arg Ala 
        355             


<210>  2825
<211>  23
<212>  PRT
<213>  Homo Sapiens

<400>  2825

Met Ala Leu Thr Leu Phe Asp Thr Asp Glu Tyr Arg Pro Pro Val Trp 
1               5                   10                  15      


Lys Ser Tyr Cys Phe Met Ala 
            20              


<210>  2826
<211>  459
<212>  PRT
<213>  Homo Sapiens

<400>  2826

Met Ala Leu Thr Leu Phe Asp Thr Asp Glu Tyr Arg Pro Pro Val Trp 
1               5                   10                  15      


Lys Ser Tyr Leu Tyr Gln Leu Gln Gln Glu Ala Pro His Pro Arg Arg 
            20                  25                  30          


Ile Thr Cys Thr Cys Glu Val Glu Asn Arg Pro Lys Tyr Tyr Gly Arg 
        35                  40                  45              


Glu Phe His Gly Met Ile Ser Arg Glu Ala Ala Asp Gln Leu Leu Ile 
    50                  55                  60                  


Val Ala Glu Gly Ser Tyr Leu Ile Arg Glu Ser Gln Arg Gln Pro Gly 
65                  70                  75                  80  


Thr Tyr Thr Leu Ala Leu Arg Phe Gly Ser Gln Thr Arg Asn Phe Arg 
                85                  90                  95      


Leu Tyr Tyr Asp Gly Lys His Phe Val Gly Glu Lys Arg Phe Glu Ser 
            100                 105                 110         


Ile His Asp Leu Val Thr Asp Gly Leu Ile Thr Leu Tyr Ile Glu Thr 
        115                 120                 125             


Lys Ala Ala Glu Tyr Ile Ala Lys Met Thr Ile Asn Pro Ile Tyr Glu 
    130                 135                 140                 


His Val Gly Tyr Thr Thr Leu Asn Arg Glu Pro Ala Tyr Lys Lys His 
145                 150                 155                 160 


Met Pro Val Leu Lys Glu Thr His Asp Glu Arg Asp Ser Thr Gly Gln 
                165                 170                 175     


Asp Gly Val Ser Glu Lys Arg Leu Thr Ser Leu Val Arg Arg Ala Thr 
            180                 185                 190         


Leu Lys Glu Asn Glu Gln Ile Pro Lys Tyr Glu Lys Ile His Asn Phe 
        195                 200                 205             


Lys Val His Thr Phe Arg Gly Pro His Trp Cys Glu Tyr Cys Ala Asn 
    210                 215                 220                 


Phe Met Trp Gly Leu Ile Ala Gln Gly Val Lys Cys Ala Asp Cys Gly 
225                 230                 235                 240 


Leu Asn Val His Lys Gln Cys Ser Lys Met Val Pro Asn Asp Cys Lys 
                245                 250                 255     


Pro Asp Leu Lys His Val Lys Lys Val Tyr Ser Cys Asp Leu Thr Thr 
            260                 265                 270         


Leu Val Lys Ala His Thr Thr Lys Arg Pro Met Val Val Asp Met Cys 
        275                 280                 285             


Ile Arg Glu Ile Glu Ser Arg Gly Leu Asn Ser Glu Gly Leu Tyr Arg 
    290                 295                 300                 


Val Ser Gly Phe Ser Asp Leu Ile Glu Asp Val Lys Met Ala Phe Asp 
305                 310                 315                 320 


Arg Asp Gly Glu Lys Ala Asp Ile Ser Val Asn Met Tyr Glu Asp Ile 
                325                 330                 335     


Asn Ile Ile Thr Gly Ala Leu Lys Leu Tyr Phe Arg Asp Leu Pro Ile 
            340                 345                 350         


Pro Leu Ile Thr Tyr Asp Ala Tyr Pro Lys Phe Ile Glu Ser Ala Lys 
        355                 360                 365             


Ile Met Asp Pro Asp Glu Gln Leu Glu Thr Leu His Glu Ala Leu Lys 
    370                 375                 380                 


Leu Leu Pro Pro Ala His Cys Glu Thr Leu Arg Tyr Leu Met Ala His 
385                 390                 395                 400 


Leu Lys Arg Val Thr Leu His Glu Lys Glu Asn Leu Met Asn Ala Glu 
                405                 410                 415     


Asn Leu Gly Ile Val Phe Gly Pro Thr Leu Met Arg Ser Pro Glu Leu 
            420                 425                 430         


Asp Ala Met Ala Ala Leu Asn Asp Ile Arg Tyr Gln Arg Leu Val Val 
        435                 440                 445             


Glu Leu Leu Ile Lys Asn Glu Asp Ile Leu Phe 
    450                 455                 


<210>  2827
<211>  433
<212>  PRT
<213>  Homo Sapiens

<400>  2827

Met Ala Leu Thr Leu Phe Asp Thr Asp Glu Tyr Arg Pro Pro Val Trp 
1               5                   10                  15      


Lys Ser Tyr Leu Tyr Gln Leu Gln Gln Glu Ala Pro His Pro Arg Arg 
            20                  25                  30          


Ile Thr Cys Thr Cys Glu Val Glu Asn Arg Pro Lys Tyr Tyr Gly Arg 
        35                  40                  45              


Glu Phe His Gly Met Ile Ser Arg Glu Ala Ala Asp Gln Leu Leu Ile 
    50                  55                  60                  


Val Ala Glu Gly Ser Tyr Leu Ile Arg Glu Ser Gln Arg Gln Pro Gly 
65                  70                  75                  80  


Thr Tyr Thr Leu Ala Leu Arg Phe Gly Ser Gln Thr Arg Asn Phe Arg 
                85                  90                  95      


Leu Tyr Tyr Asp Gly Lys His Phe Val Gly Glu Lys Arg Phe Glu Ser 
            100                 105                 110         


Ile His Asp Leu Val Thr Asp Gly Leu Ile Thr Leu Tyr Ile Glu Thr 
        115                 120                 125             


Lys Ala Ala Glu Tyr Ile Ala Lys Met Thr Ile Asn Pro Ile Tyr Glu 
    130                 135                 140                 


His Val Gly Tyr Thr Thr Leu Asn Arg Glu Pro Ala Tyr Lys Lys His 
145                 150                 155                 160 


Met Pro Val Leu Lys Glu Thr His Asp Glu Arg Asp Ser Thr Gly Gln 
                165                 170                 175     


Asp Gly Val Ser Glu Lys Arg Val His Thr Phe Arg Gly Pro His Trp 
            180                 185                 190         


Cys Glu Tyr Cys Ala Asn Phe Met Trp Gly Leu Ile Ala Gln Gly Val 
        195                 200                 205             


Lys Cys Ala Asp Cys Gly Leu Asn Val His Lys Gln Cys Ser Lys Met 
    210                 215                 220                 


Val Pro Asn Asp Cys Lys Pro Asp Leu Lys His Val Lys Lys Val Tyr 
225                 230                 235                 240 


Ser Cys Asp Leu Thr Thr Leu Val Lys Ala His Thr Thr Lys Arg Pro 
                245                 250                 255     


Met Val Val Asp Met Cys Ile Arg Glu Ile Glu Ser Arg Gly Leu Asn 
            260                 265                 270         


Ser Glu Gly Leu Tyr Arg Val Ser Gly Phe Ser Asp Leu Ile Glu Asp 
        275                 280                 285             


Val Lys Met Ala Phe Asp Arg Asp Gly Glu Lys Ala Asp Ile Ser Val 
    290                 295                 300                 


Asn Met Tyr Glu Asp Ile Asn Ile Ile Thr Gly Ala Leu Lys Leu Tyr 
305                 310                 315                 320 


Phe Arg Asp Leu Pro Ile Pro Leu Ile Thr Tyr Asp Ala Tyr Pro Lys 
                325                 330                 335     


Phe Ile Glu Ser Ala Lys Ile Met Asp Pro Asp Glu Gln Leu Glu Thr 
            340                 345                 350         


Leu His Glu Ala Leu Lys Leu Leu Pro Pro Ala His Cys Glu Thr Leu 
        355                 360                 365             


Arg Tyr Leu Met Ala His Leu Lys Arg Val Thr Leu His Glu Lys Glu 
    370                 375                 380                 


Asn Leu Met Asn Ala Glu Asn Leu Gly Ile Val Phe Gly Pro Thr Leu 
385                 390                 395                 400 


Met Arg Ser Pro Glu Leu Asp Ala Met Ala Ala Leu Asn Asp Ile Arg 
                405                 410                 415     


Tyr Gln Arg Leu Val Val Glu Leu Leu Ile Lys Asn Glu Asp Ile Leu 
            420                 425                 430         


Phe 
    


<210>  2828
<211>  22
<212>  PRT
<213>  Homo Sapiens

<400>  2828

Met Ala Leu Thr Leu Phe Asp Thr Asp Glu Tyr Arg Pro Pro Val Trp 
1               5                   10                  15      


Lys Ser Tyr Tyr Ile Leu 
            20          


<210>  2829
<211>  185
<212>  PRT
<213>  Homo Sapiens

<400>  2829

Met Ala Thr Met Gly Leu Leu Met Leu Leu Thr Leu Ala Ala Ser Pro 
1               5                   10                  15      


His Phe Leu Ser Ile Cys Phe His His Val Cys Val His Thr Phe Arg 
            20                  25                  30          


Gly Pro His Trp Cys Glu Tyr Cys Ala Asn Phe Met Trp Gly Leu Ile 
        35                  40                  45              


Ala Gln Gly Val Lys Cys Ala Asp Cys Gly Leu Asn Val His Lys Gln 
    50                  55                  60                  


Cys Ser Lys Met Val Pro Asn Asp Cys Lys Pro Asp Leu Lys His Val 
65                  70                  75                  80  


Lys Lys Val Tyr Ser Cys Asp Leu Thr Thr Leu Val Lys Ala His Thr 
                85                  90                  95      


Thr Lys Arg Pro Met Val Val Asp Met Cys Ile Arg Glu Ile Glu Ser 
            100                 105                 110         


Arg Gly Leu Asn Ser Glu Gly Leu Tyr Arg Val Ser Gly Phe Ser Asp 
        115                 120                 125             


Leu Ile Glu Asp Val Lys Met Ala Phe Asp Arg Asp Gly Glu Lys Ala 
    130                 135                 140                 


Asp Ile Ser Val Asn Met Tyr Glu Asp Ile Asn Ile Ile Thr Gly Ala 
145                 150                 155                 160 


Leu Lys Leu Tyr Phe Arg Asp Leu Pro Ile Pro Leu Ile Thr Tyr Asp 
                165                 170                 175     


Ala Tyr Pro Lys Phe Ile Glu Ser Ala 
            180                 185 


<210>  2830
<211>  275
<212>  PRT
<213>  Homo Sapiens

<400>  2830

Met Ala Thr Met Gly Leu Leu Met Leu Leu Thr Leu Ala Ala Ser Pro 
1               5                   10                  15      


His Phe Leu Ser Ile Cys Phe His His Val His Thr Phe Arg Gly Pro 
            20                  25                  30          


His Trp Cys Glu Tyr Cys Ala Asn Phe Met Trp Gly Leu Ile Ala Gln 
        35                  40                  45              


Gly Val Lys Cys Ala Asp Cys Gly Leu Asn Val His Lys Gln Cys Ser 
    50                  55                  60                  


Lys Met Val Pro Asn Asp Cys Lys Pro Asp Leu Lys His Val Lys Lys 
65                  70                  75                  80  


Val Tyr Ser Cys Asp Leu Thr Thr Leu Val Lys Ala His Thr Thr Lys 
                85                  90                  95      


Arg Pro Met Val Val Asp Met Cys Ile Arg Glu Ile Glu Ser Arg Gly 
            100                 105                 110         


Leu Asn Ser Glu Gly Leu Tyr Arg Val Ser Gly Phe Ser Asp Leu Ile 
        115                 120                 125             


Glu Asp Val Lys Met Ala Phe Asp Arg Asp Gly Glu Lys Ala Asp Ile 
    130                 135                 140                 


Ser Val Asn Met Tyr Glu Asp Ile Asn Ile Ile Thr Gly Ala Leu Lys 
145                 150                 155                 160 


Leu Tyr Phe Arg Asp Leu Pro Ile Pro Leu Ile Thr Tyr Asp Ala Tyr 
                165                 170                 175     


Pro Lys Phe Ile Glu Ser Ala Lys Ile Met Asp Pro Asp Glu Gln Leu 
            180                 185                 190         


Glu Thr Leu His Glu Ala Leu Lys Leu Leu Pro Pro Ala His Cys Glu 
        195                 200                 205             


Thr Leu Arg Tyr Leu Met Ala His Leu Lys Arg Val Thr Leu His Glu 
    210                 215                 220                 


Lys Glu Asn Leu Met Asn Ala Glu Asn Leu Gly Ile Val Phe Gly Pro 
225                 230                 235                 240 


Thr Leu Met Arg Ser Pro Glu Leu Asp Ala Met Ala Ala Leu Asn Asp 
                245                 250                 255     


Ile Arg Tyr Gln Arg Leu Val Val Glu Leu Leu Ile Lys Asn Glu Asp 
            260                 265                 270         


Ile Leu Phe 
        275 


<210>  2831
<211>  334
<212>  PRT
<213>  Homo Sapiens

<400>  2831

Met Pro Ser Lys Glu Ser Trp Ser Gly Arg Lys Thr Asn Arg Ala Ala 
1               5                   10                  15      


Val His Lys Ser Lys Gln Glu Gly Arg Gln Gln Asp Leu Leu Ile Ala 
            20                  25                  30          


Ala Leu Gly Met Lys Leu Gly Ser Pro Lys Ser Ser Val Thr Ile Trp 
        35                  40                  45              


Gln Pro Leu Lys Leu Phe Ala Tyr Ser Gln Leu Thr Ser Leu Val Arg 
    50                  55                  60                  


Arg Ala Thr Leu Lys Glu Asn Glu Gln Ile Pro Lys Tyr Glu Lys Ile 
65                  70                  75                  80  


His Asn Phe Lys Val His Thr Phe Arg Gly Pro His Trp Cys Glu Tyr 
                85                  90                  95      


Cys Ala Asn Phe Met Trp Gly Leu Ile Ala Gln Gly Val Lys Cys Ala 
            100                 105                 110         


Asp Cys Gly Leu Asn Val His Lys Gln Cys Ser Lys Met Val Pro Asn 
        115                 120                 125             


Asp Cys Lys Pro Asp Leu Lys His Val Lys Lys Val Tyr Ser Cys Asp 
    130                 135                 140                 


Leu Thr Thr Leu Val Lys Ala His Thr Thr Lys Arg Pro Met Val Val 
145                 150                 155                 160 


Asp Met Cys Ile Arg Glu Ile Glu Ser Arg Gly Leu Asn Ser Glu Gly 
                165                 170                 175     


Leu Tyr Arg Val Ser Gly Phe Ser Asp Leu Ile Glu Asp Val Lys Met 
            180                 185                 190         


Ala Phe Asp Arg Asp Gly Glu Lys Ala Asp Ile Ser Val Asn Met Tyr 
        195                 200                 205             


Glu Asp Ile Asn Ile Ile Thr Gly Ala Leu Lys Leu Tyr Phe Arg Asp 
    210                 215                 220                 


Leu Pro Ile Pro Leu Ile Thr Tyr Asp Ala Tyr Pro Lys Phe Ile Glu 
225                 230                 235                 240 


Ser Ala Lys Ile Met Asp Pro Asp Glu Gln Leu Glu Thr Leu His Glu 
                245                 250                 255     


Ala Leu Lys Leu Leu Pro Pro Ala His Cys Glu Thr Leu Arg Tyr Leu 
            260                 265                 270         


Met Ala His Leu Lys Arg Val Thr Leu His Glu Lys Glu Asn Leu Met 
        275                 280                 285             


Asn Ala Glu Asn Leu Gly Ile Val Phe Gly Pro Thr Leu Met Arg Ser 
    290                 295                 300                 


Pro Glu Leu Asp Ala Met Ala Ala Leu Asn Asp Ile Arg Tyr Gln Arg 
305                 310                 315                 320 


Leu Val Val Glu Leu Leu Ile Lys Asn Glu Asp Ile Leu Phe 
                325                 330                 


<210>  2832
<211>  165
<212>  PRT
<213>  Homo Sapiens

<400>  2832

Met Pro Ser Lys Glu Ser Trp Ser Gly Arg Lys Thr Asn Arg Ala Ala 
1               5                   10                  15      


Val His Lys Ser Lys Gln Glu Gly Arg Gln Gln Asp Leu Leu Ile Ala 
            20                  25                  30          


Ala Leu Gly Met Lys Leu Gly Ser Pro Lys Ser Ser Val Thr Ile Trp 
        35                  40                  45              


Gln Pro Leu Lys Leu Phe Ala Tyr Ser Gln Leu Thr Ser Leu Val Arg 
    50                  55                  60                  


Arg Ala Thr Leu Lys Glu Asn Glu Gln Ile Pro Lys Tyr Glu Lys Ile 
65                  70                  75                  80  


His Asn Phe Lys Val His Thr Phe Arg Gly Pro His Trp Cys Glu Tyr 
                85                  90                  95      


Cys Ala Asn Phe Met Trp Gly Leu Ile Ala Gln Gly Val Lys Cys Ala 
            100                 105                 110         


Val Leu Glu Ala Arg Lys Ser Lys Ile Lys Leu Ala Ala Gly Ser Val 
        115                 120                 125             


Ser Asp Cys Gly Leu Asn Val His Lys Gln Cys Ser Lys Met Val Pro 
    130                 135                 140                 


Asn Asp Cys Lys Pro Asp Leu Lys His Val Lys Lys Val Tyr Ser Cys 
145                 150                 155                 160 


Asp Leu Thr Thr Leu 
                165 


<210>  2833
<211>  186
<212>  PRT
<213>  Homo Sapiens

<400>  2833

Met Arg Gly Gly Arg Asn Arg Asp Arg Leu Thr Ser Leu Val Arg Arg 
1               5                   10                  15      


Ala Thr Leu Lys Glu Asn Glu Gln Ile Pro Lys Tyr Glu Lys Ile His 
            20                  25                  30          


Asn Phe Lys Val His Thr Phe Arg Gly Pro His Trp Cys Glu Tyr Cys 
        35                  40                  45              


Ala Asn Phe Met Trp Gly Leu Ile Ala Gln Gly Val Lys Cys Ala Asp 
    50                  55                  60                  


Cys Gly Leu Asn Val His Lys Gln Cys Ser Lys Met Val Pro Asn Asp 
65                  70                  75                  80  


Cys Lys Pro Asp Leu Lys His Val Lys Lys Val Tyr Ser Cys Asp Leu 
                85                  90                  95      


Thr Thr Leu Val Lys Ala His Thr Thr Lys Arg Pro Met Val Val Asp 
            100                 105                 110         


Met Cys Ile Arg Glu Ile Glu Ser Arg Gly Leu Asn Ser Glu Gly Leu 
        115                 120                 125             


Tyr Arg Val Ser Gly Phe Ser Asp Leu Ile Glu Asp Val Lys Met Ala 
    130                 135                 140                 


Phe Asp Arg Asp Gly Glu Lys Ala Asp Ile Ser Val Asn Met Tyr Glu 
145                 150                 155                 160 


Asp Ile Asn Ile Ile Thr Gly Ala Leu Lys Leu Tyr Phe Arg Asp Leu 
                165                 170                 175     


Pro Ile Pro Leu Ile Thr Tyr Asp Ala Tyr 
            180                 185     


<210>  2834
<211>  173
<212>  PRT
<213>  Homo Sapiens

<400>  2834

Met Trp Gly Leu Ile Ala Gln Gly Val Lys Cys Ala Asp Cys Gly Leu 
1               5                   10                  15      


Asn Val His Lys Gln Cys Ser Lys Met Val Pro Asn Asp Cys Lys Pro 
            20                  25                  30          


Asp Leu Lys His Val Lys Lys Val Tyr Ser Cys Asp Leu Thr Thr Leu 
        35                  40                  45              


Val Lys Ala His Thr Thr Lys Arg Pro Met Val Val Asp Met Cys Ile 
    50                  55                  60                  


Arg Glu Ile Glu Ser Arg Gly Leu Asn Ser Glu Gly Leu Tyr Arg Val 
65                  70                  75                  80  


Ser Gly Phe Ser Asp Leu Ile Glu Asp Val Lys Met Ala Phe Asp Arg 
                85                  90                  95      


Asp Gly Glu Lys Ala Asp Ile Ser Val Asn Met Tyr Glu Asp Ile Asn 
            100                 105                 110         


Ile Ile Thr Gly Ala Leu Lys Leu Tyr Phe Arg Asp Leu Pro Ile Pro 
        115                 120                 125             


Leu Ile Thr Tyr Asp Ala Tyr Pro Lys Phe Ile Glu Ser Ala Lys Ile 
    130                 135                 140                 


Met Asp Pro Asp Glu Gln Leu Glu Thr Leu His Glu Ala Leu Lys Leu 
145                 150                 155                 160 


Leu Pro Pro Ala His Cys Glu Thr Leu Arg Tyr Leu Met 
                165                 170             


<210>  2835
<211>  194
<212>  PRT
<213>  Homo Sapiens

<400>  2835

Met Trp Gly Leu Ile Ala Gln Gly Val Lys Cys Ala Val Leu Glu Ala 
1               5                   10                  15      


Arg Lys Ser Lys Ile Lys Leu Ala Ala Gly Ser Val Ser Asp Cys Gly 
            20                  25                  30          


Leu Asn Val His Lys Gln Cys Ser Lys Met Val Pro Asn Asp Cys Lys 
        35                  40                  45              


Pro Asp Leu Lys His Val Lys Lys Val Tyr Ser Cys Asp Leu Thr Thr 
    50                  55                  60                  


Leu Val Lys Ala His Thr Thr Lys Arg Pro Met Val Val Asp Met Cys 
65                  70                  75                  80  


Ile Arg Glu Ile Glu Ser Arg Gly Leu Asn Ser Glu Gly Leu Tyr Arg 
                85                  90                  95      


Val Ser Gly Phe Ser Asp Leu Ile Glu Asp Val Lys Met Ala Phe Asp 
            100                 105                 110         


Arg Asp Gly Glu Lys Ala Asp Ile Ser Val Asn Met Tyr Glu Asp Ile 
        115                 120                 125             


Asn Ile Ile Thr Gly Ala Leu Lys Leu Tyr Phe Arg Asp Leu Pro Ile 
    130                 135                 140                 


Pro Leu Ile Thr Tyr Asp Ala Tyr Pro Lys Phe Ile Glu Ser Ala Lys 
145                 150                 155                 160 


Ile Met Asp Pro Asp Glu Gln Leu Glu Thr Leu His Glu Ala Leu Lys 
                165                 170                 175     


Leu Leu Pro Pro Ala His Cys Glu Thr Leu Arg Tyr Leu Met Ala His 
            180                 185                 190         


Leu Lys 
        


<210>  2836
<211>  613
<212>  PRT
<213>  Homo Sapiens

<400>  2836

Met Ala Val Val Thr Leu Gly Glu Glu Arg Pro Ile Gly His Leu His 
1               5                   10                  15      


Leu Ala Leu Arg His Leu Leu Glu Gln His Gly Asp Asp Phe Asp Trp 
            20                  25                  30          


Phe Phe Leu Val Pro Asp Thr Thr Tyr Thr Glu Ala His Gly Leu Ala 
        35                  40                  45              


Arg Leu Thr Gly His Leu Ser Leu Ala Ser Ala Ala His Leu Tyr Leu 
    50                  55                  60                  


Gly Arg Pro Gln Asp Phe Ile Gly Gly Glu Pro Thr Pro Gly Arg Tyr 
65                  70                  75                  80  


Cys His Gly Gly Phe Gly Val Leu Leu Ser Arg Met Leu Leu Gln Gln 
                85                  90                  95      


Leu Arg Pro His Leu Glu Gly Cys Arg Asn Asp Ile Val Ser Ala Arg 
            100                 105                 110         


Pro Asp Glu Trp Leu Gly Arg Cys Ile Leu Asp Ala Thr Gly Val Gly 
        115                 120                 125             


Cys Thr Gly Asp His Glu Gly Val His Tyr Ser His Leu Glu Leu Ser 
    130                 135                 140                 


Pro Gly Glu Pro Val Gln Glu Gly Asp Pro His Phe Arg Ser Ala Leu 
145                 150                 155                 160 


Thr Ala His Pro Val Arg Asp Pro Val His Met Tyr Gln Leu His Lys 
                165                 170                 175     


Ala Phe Ala Arg Ala Glu Leu Glu Arg Thr Tyr Gln Glu Ile Gln Glu 
            180                 185                 190         


Leu Gln Trp Glu Ile Gln Asn Thr Ser His Leu Ala Val Asp Gly Asp 
        195                 200                 205             


Gln Ala Ala Ala Trp Pro Val Gly Ile Pro Ala Pro Ser Arg Pro Ala 
    210                 215                 220                 


Ser Arg Phe Glu Val Leu Arg Trp Asp Tyr Phe Thr Glu Gln His Ala 
225                 230                 235                 240 


Phe Ser Cys Ala Asp Gly Ser Pro Arg Cys Pro Leu Arg Gly Ala Asp 
                245                 250                 255     


Arg Ala Asp Val Ala Asp Val Leu Gly Thr Ala Leu Glu Glu Leu Asn 
            260                 265                 270         


Arg Arg Tyr His Pro Ala Leu Arg Leu Gln Lys Gln Gln Leu Val Asn 
        275                 280                 285             


Gly Tyr Arg Arg Phe Asp Pro Ala Arg Gly Met Glu Tyr Thr Leu Asp 
    290                 295                 300                 


Leu Gln Leu Glu Ala Leu Thr Pro Gln Gly Gly Arg Arg Pro Leu Thr 
305                 310                 315                 320 


Arg Arg Val Gln Leu Leu Arg Pro Leu Ser Arg Val Glu Ile Leu Pro 
                325                 330                 335     


Val Pro Tyr Val Thr Glu Ala Ser Arg Leu Thr Val Leu Leu Pro Leu 
            340                 345                 350         


Ala Ala Ala Glu Arg Asp Leu Ala Pro Gly Phe Leu Glu Ala Phe Ala 
        355                 360                 365             


Thr Ala Ala Leu Glu Pro Gly Asp Ala Ala Ala Ala Leu Thr Leu Leu 
    370                 375                 380                 


Leu Leu Tyr Glu Pro Arg Gln Ala Gln Arg Val Ala His Ala Asp Val 
385                 390                 395                 400 


Phe Ala Pro Val Lys Ala His Val Ala Glu Leu Glu Arg Arg Phe Pro 
                405                 410                 415     


Gly Ala Arg Val Pro Trp Leu Ser Val Gln Thr Ala Ala Pro Ser Pro 
            420                 425                 430         


Leu Arg Leu Met Asp Leu Leu Ser Lys Lys His Pro Leu Asp Thr Leu 
        435                 440                 445             


Phe Leu Leu Ala Gly Pro Asp Thr Val Leu Thr Pro Asp Phe Leu Asn 
    450                 455                 460                 


Arg Cys Arg Met His Ala Ile Ser Gly Trp Gln Ala Phe Phe Pro Met 
465                 470                 475                 480 


His Phe Gln Ala Phe His Pro Ala Val Ala Pro Pro Gln Gly Pro Gly 
                485                 490                 495     


Pro Pro Glu Leu Gly Arg Asp Thr Gly Arg Phe Asp Arg Gln Ala Ala 
            500                 505                 510         


Ser Glu Ala Cys Phe Tyr Asn Ser Asp Tyr Val Ala Ala Arg Gly Arg 
        515                 520                 525             


Leu Ala Ala Ala Ser Glu Gln Glu Glu Glu Leu Leu Glu Ser Leu Asp 
    530                 535                 540                 


Val Tyr Glu Leu Phe Leu His Phe Ser Ser Leu His Val Leu Arg Ala 
545                 550                 555                 560 


Val Glu Pro Ala Leu Leu Gln Arg Tyr Arg Ala Gln Thr Cys Ser Ala 
                565                 570                 575     


Arg Leu Ser Glu Asp Leu Tyr His Arg Cys Leu Gln Ser Val Leu Glu 
            580                 585                 590         


Gly Leu Gly Ser Arg Thr Gln Leu Ala Met Leu Leu Phe Glu Gln Glu 
        595                 600                 605             


Gln Gly Asn Ser Thr 
    610             


<210>  2837
<211>  775
<212>  PRT
<213>  Homo Sapiens

<400>  2837

Met Arg Ala Ser Leu Leu Leu Ser Val Leu Arg Pro Ala Gly Pro Val 
1               5                   10                  15      


Ala Val Gly Ile Ser Leu Gly Phe Thr Leu Ser Leu Leu Ser Val Thr 
            20                  25                  30          


Trp Val Glu Glu Pro Cys Gly Pro Gly Pro Pro Gln Pro Gly Asp Ser 
        35                  40                  45              


Glu Leu Pro Pro Arg Gly Asn Thr Asn Ala Ala Arg Arg Pro Asn Ser 
    50                  55                  60                  


Val Gln Pro Gly Ala Glu Arg Glu Lys Pro Gly Ala Gly Glu Gly Ala 
65                  70                  75                  80  


Gly Glu Asn Trp Glu Pro Arg Val Leu Pro Tyr His Pro Ala Gln Pro 
                85                  90                  95      


Gly Gln Ala Ala Lys Lys Ala Val Arg Thr Arg Tyr Ile Ser Thr Glu 
            100                 105                 110         


Leu Gly Ile Arg Gln Arg Leu Leu Val Ala Val Leu Thr Ser Gln Thr 
        115                 120                 125             


Thr Leu Pro Thr Leu Gly Val Ala Val Asn Arg Thr Leu Gly His Arg 
    130                 135                 140                 


Leu Glu Arg Val Val Phe Leu Thr Gly Ala Arg Gly Arg Arg Ala Pro 
145                 150                 155                 160 


Pro Gly Met Ala Val Val Thr Leu Gly Glu Glu Arg Pro Ile Gly His 
                165                 170                 175     


Leu His Leu Ala Leu Arg His Leu Leu Glu Gln His Gly Asp Asp Phe 
            180                 185                 190         


Asp Trp Phe Phe Leu Val Pro Asp Thr Thr Tyr Thr Glu Ala His Gly 
        195                 200                 205             


Leu Ala Arg Leu Thr Gly His Leu Ser Leu Ala Ser Ala Ala His Leu 
    210                 215                 220                 


Tyr Leu Gly Arg Pro Gln Asp Phe Ile Gly Gly Glu Pro Thr Pro Gly 
225                 230                 235                 240 


Arg Tyr Cys His Gly Gly Phe Gly Val Leu Leu Ser Arg Met Leu Leu 
                245                 250                 255     


Gln Gln Leu Arg Pro His Leu Glu Gly Cys Arg Asn Asp Ile Val Ser 
            260                 265                 270         


Ala Arg Pro Asp Glu Trp Leu Gly Arg Cys Ile Leu Asp Ala Thr Gly 
        275                 280                 285             


Val Gly Cys Thr Gly Asp His Glu Gly Val His Tyr Ser His Leu Glu 
    290                 295                 300                 


Leu Ser Pro Gly Glu Pro Val Gln Glu Gly Asp Pro His Phe Arg Ser 
305                 310                 315                 320 


Ala Leu Thr Ala His Pro Val Arg Asp Pro Val His Met Tyr Gln Leu 
                325                 330                 335     


His Lys Ala Phe Ala Arg Ala Glu Leu Glu Arg Thr Tyr Gln Glu Ile 
            340                 345                 350         


Gln Glu Leu Gln Trp Glu Ile Gln Asn Thr Ser His Leu Ala Val Asp 
        355                 360                 365             


Gly Asp Gln Ala Ala Ala Trp Pro Val Gly Ile Pro Ala Pro Ser Arg 
    370                 375                 380                 


Pro Ala Ser Arg Phe Glu Val Leu Arg Trp Asp Tyr Phe Thr Glu Gln 
385                 390                 395                 400 


His Ala Phe Ser Cys Ala Asp Gly Ser Pro Arg Cys Pro Leu Arg Gly 
                405                 410                 415     


Ala Asp Arg Ala Asp Val Ala Asp Val Leu Gly Thr Ala Leu Glu Glu 
            420                 425                 430         


Leu Asn Arg Arg Tyr His Pro Ala Leu Arg Leu Gln Lys Gln Gln Leu 
        435                 440                 445             


Val Asn Gly Tyr Arg Arg Phe Asp Pro Ala Arg Gly Met Glu Tyr Thr 
    450                 455                 460                 


Leu Asp Leu Gln Leu Glu Ala Leu Thr Pro Gln Gly Gly Arg Arg Pro 
465                 470                 475                 480 


Leu Thr Arg Arg Val Gln Leu Leu Arg Pro Leu Ser Arg Val Glu Ile 
                485                 490                 495     


Leu Pro Val Pro Tyr Val Thr Glu Ala Ser Arg Leu Thr Val Leu Leu 
            500                 505                 510         


Pro Leu Ala Ala Ala Glu Arg Asp Leu Ala Pro Gly Phe Leu Glu Ala 
        515                 520                 525             


Phe Ala Thr Ala Ala Leu Glu Pro Gly Asp Ala Ala Ala Ala Leu Thr 
    530                 535                 540                 


Leu Leu Leu Leu Tyr Glu Pro Arg Gln Ala Gln Arg Val Ala His Ala 
545                 550                 555                 560 


Asp Val Phe Ala Pro Val Lys Ala His Val Ala Glu Leu Glu Arg Arg 
                565                 570                 575     


Phe Pro Gly Ala Arg Val Pro Trp Leu Ser Val Gln Thr Ala Ala Pro 
            580                 585                 590         


Ser Pro Leu Arg Leu Met Asp Leu Leu Ser Lys Lys His Pro Leu Asp 
        595                 600                 605             


Thr Leu Phe Leu Leu Ala Gly Pro Asp Thr Val Leu Thr Pro Asp Phe 
    610                 615                 620                 


Leu Asn Arg Cys Arg Met His Ala Ile Ser Gly Trp Gln Ala Phe Phe 
625                 630                 635                 640 


Pro Met His Phe Gln Ala Phe His Pro Ala Val Ala Pro Pro Gln Gly 
                645                 650                 655     


Pro Gly Pro Pro Glu Leu Gly Arg Asp Thr Gly Arg Phe Asp Arg Gln 
            660                 665                 670         


Ala Ala Ser Glu Ala Cys Phe Tyr Asn Ser Asp Tyr Val Ala Ala Arg 
        675                 680                 685             


Gly Arg Leu Ala Ala Ala Ser Glu Gln Glu Glu Glu Leu Leu Glu Ser 
    690                 695                 700                 


Leu Asp Val Tyr Glu Leu Phe Leu His Phe Ser Ser Leu His Val Leu 
705                 710                 715                 720 


Arg Ala Val Glu Pro Ala Leu Leu Gln Arg Tyr Arg Ala Gln Thr Cys 
                725                 730                 735     


Ser Ala Arg Leu Ser Glu Asp Leu Tyr His Arg Cys Leu Gln Ser Val 
            740                 745                 750         


Leu Glu Gly Leu Gly Ser Arg Thr Gln Leu Ala Met Leu Leu Phe Glu 
        755                 760                 765             


Gln Glu Gln Gly Asn Ser Thr 
    770                 775 


<210>  2838
<211>  298
<212>  PRT
<213>  Homo Sapiens

<400>  2838

Met Arg Ala Ser Leu Leu Leu Ser Val Leu Arg Pro Ala Gly Pro Val 
1               5                   10                  15      


Ala Val Gly Ile Ser Leu Gly Phe Thr Leu Ser Leu Leu Ser Val Thr 
            20                  25                  30          


Trp Val Glu Glu Pro Cys Gly Pro Gly Pro Pro Gln Pro Gly Asp Ser 
        35                  40                  45              


Glu Leu Pro Pro Arg Gly Asn Thr Asn Ala Ala Arg Arg Pro Asn Ser 
    50                  55                  60                  


Val Gln Pro Gly Ala Glu Arg Glu Lys Pro Gly Ala Gly Glu Gly Ala 
65                  70                  75                  80  


Gly Glu Asn Trp Glu Pro Arg Val Leu Pro Tyr His Pro Ala Gln Pro 
                85                  90                  95      


Gly Gln Ala Ala Lys Lys Ala Val Arg Thr Arg Tyr Ile Ser Thr Glu 
            100                 105                 110         


Leu Gly Ile Arg Gln Arg Leu Leu Val Ala Val Leu Thr Ser Gln Thr 
        115                 120                 125             


Thr Leu Pro Thr Leu Gly Val Ala Val Asn Arg Thr Leu Gly His Arg 
    130                 135                 140                 


Leu Glu Arg Val Val Phe Leu Thr Gly Ala Arg Gly Arg Arg Ala Pro 
145                 150                 155                 160 


Pro Gly Met Ala Val Val Thr Leu Gly Glu Glu Arg Pro Ile Gly His 
                165                 170                 175     


Leu His Leu Ala Leu Arg His Leu Leu Glu Gln His Gly Asp Asp Phe 
            180                 185                 190         


Asp Trp Phe Phe Leu Val Pro Asp Thr Thr Tyr Thr Glu Ala His Gly 
        195                 200                 205             


Leu Ala Arg Leu Thr Gly His Leu Ser Leu Ala Ser Ala Ala His Leu 
    210                 215                 220                 


Tyr Leu Gly Arg Pro Gln Asp Phe Ile Gly Gly Glu Pro Thr Pro Gly 
225                 230                 235                 240 


Arg Tyr Cys His Gly Gly Phe Gly Val Leu Leu Ser Arg Met Leu Leu 
                245                 250                 255     


Gln Gln Leu Arg Pro His Leu Glu Gly Cys Arg Asn Asp Ile Val Ser 
            260                 265                 270         


Ala Arg Pro Asp Glu Trp Leu Gly Arg Cys Ile Leu Asp Ala Thr Gly 
        275                 280                 285             


Val Gly Cys Thr Gly Asp His Glu Val Gly 
    290                 295             


<210>  2839
<211>  123
<212>  PRT
<213>  Homo Sapiens

<400>  2839

Cys His Gly Gly Phe Gly Tyr Leu Leu Ser Arg Ser Leu Leu Leu Arg 
1               5                   10                  15      


Leu Arg Pro His Leu Asp Gly Cys Arg Gly Asp Ile Leu Ser Ala Arg 
            20                  25                  30          


Pro Asp Glu Trp Leu Gly Arg Cys Leu Ile Asp Ser Leu Gly Val Gly 
        35                  40                  45              


Cys Val Ser Gln His Gln Gly Gln Gln Tyr Arg Ser Phe Glu Leu Ala 
    50                  55                  60                  


Lys Asn Arg Asp Pro Glu Lys Glu Gly Ser Ser Ala Phe Leu Ser Ala 
65                  70                  75                  80  


Phe Ala Val His Pro Val Ser Glu Gly Thr Leu Met Tyr Arg Leu His 
                85                  90                  95      


Lys Arg Phe Ser Ala Leu Glu Leu Glu Arg Ala Tyr Ser Glu Ile Glu 
            100                 105                 110         


Gln Leu Gln Asn Cys Pro Lys Lys Ala Gln Gly 
        115                 120             


<210>  2840
<211>  90
<212>  PRT
<213>  Homo Sapiens

<400>  2840

Met Leu Ser Leu Ala Arg Pro Pro Leu Pro Pro Thr Gly Leu Arg Thr 
1               5                   10                  15      


Arg Thr Arg Tyr Ile Gln Thr Glu Leu Gly Ser Arg Glu Arg Leu Leu 
            20                  25                  30          


Val Ala Val Leu Thr Ser Arg Ala Thr Leu Ser Thr Leu Ala Val Ala 
        35                  40                  45              


Val Asn Arg Thr Val Ala His His Phe Pro Arg Leu Leu Tyr Phe Thr 
    50                  55                  60                  


Gly Gln Arg Gly Ala Arg Ala Pro Ala Gly Met Gln Val Val Ser His 
65                  70                  75                  80  


Gly Asp Glu Arg Pro Ala Trp Leu Met Ser 
                85                  90  


<210>  2841
<211>  764
<212>  PRT
<213>  Homo Sapiens

<400>  2841

Met Leu Ser Leu Ala Arg Pro Pro Leu Pro Pro Thr Gly Leu Arg Thr 
1               5                   10                  15      


Ser Leu Ser Leu Leu Arg Val Ser Trp Ile Gln Gly Glu Gly Glu Asp 
            20                  25                  30          


Pro Cys Val Glu Ala Val Gly Glu Arg Gly Gly Pro Gln Asn Pro Asp 
        35                  40                  45              


Ser Arg Ala Arg Leu Asp Gln Ser Asp Glu Asp Phe Lys Pro Arg Ile 
    50                  55                  60                  


Val Pro Tyr Tyr Arg Asp Pro Asn Lys Pro Tyr Lys Lys Val Leu Arg 
65                  70                  75                  80  


Thr Arg Tyr Ile Gln Thr Glu Leu Gly Ser Arg Glu Arg Leu Leu Val 
                85                  90                  95      


Ala Val Leu Thr Ser Arg Ala Thr Leu Ser Thr Leu Ala Val Ala Val 
            100                 105                 110         


Asn Arg Thr Val Ala His His Phe Pro Arg Leu Leu Tyr Phe Thr Gly 
        115                 120                 125             


Gln Arg Gly Ala Arg Ala Pro Ala Gly Met Gln Val Val Ser His Gly 
    130                 135                 140                 


Asp Glu Arg Pro Ala Trp Leu Met Ser Glu Thr Leu Arg His Leu His 
145                 150                 155                 160 


Thr His Phe Gly Ala Asp Tyr Asp Trp Phe Phe Ile Met Gln Asp Asp 
                165                 170                 175     


Thr Tyr Val Gln Ala Pro Arg Leu Ala Ala Leu Ala Gly His Leu Ser 
            180                 185                 190         


Ile Asn Gln Asp Leu Tyr Leu Gly Arg Ala Glu Glu Phe Ile Gly Ala 
        195                 200                 205             


Gly Glu Gln Ala Arg Tyr Cys His Gly Gly Phe Gly Tyr Leu Leu Ser 
    210                 215                 220                 


Arg Ser Leu Leu Leu Arg Leu Arg Pro His Leu Asp Gly Cys Arg Gly 
225                 230                 235                 240 


Asp Ile Leu Ser Ala Arg Pro Asp Glu Trp Leu Gly Arg Cys Leu Ile 
                245                 250                 255     


Asp Ser Leu Gly Val Gly Cys Val Ser Gln His Gln Gly Gln Gln Tyr 
            260                 265                 270         


Arg Ser Phe Glu Leu Ala Lys Asn Arg Asp Pro Glu Lys Glu Gly Ser 
        275                 280                 285             


Ser Ala Phe Leu Ser Ala Phe Ala Val His Pro Val Ser Glu Gly Thr 
    290                 295                 300                 


Leu Met Tyr Arg Leu His Lys Arg Phe Ser Ala Leu Glu Leu Glu Arg 
305                 310                 315                 320 


Ala Tyr Ser Glu Ile Glu Gln Leu Gln Ala Gln Ile Arg Asn Leu Thr 
                325                 330                 335     


Val Leu Thr Pro Glu Gly Glu Ala Gly Leu Ser Trp Pro Val Gly Leu 
            340                 345                 350         


Pro Ala Pro Phe Thr Pro His Ser Arg Phe Glu Val Leu Gly Trp Asp 
        355                 360                 365             


Tyr Phe Thr Glu Gln His Thr Phe Ser Cys Ala Asp Gly Ala Pro Lys 
    370                 375                 380                 


Cys Pro Leu Gln Gly Ala Ser Arg Ala Asp Val Gly Asp Ala Leu Glu 
385                 390                 395                 400 


Thr Ala Leu Glu Gln Leu Asn Arg Arg Tyr Gln Pro Arg Leu Arg Phe 
                405                 410                 415     


Gln Lys Gln Arg Leu Leu Asn Gly Tyr Arg Arg Phe Asp Pro Ala Arg 
            420                 425                 430         


Gly Met Glu Tyr Thr Leu Asp Leu Leu Leu Glu Cys Val Thr Gln Arg 
        435                 440                 445             


Gly His Arg Arg Ala Leu Ala Arg Arg Val Ser Leu Leu Arg Pro Leu 
    450                 455                 460                 


Ser Arg Val Glu Ile Leu Pro Met Pro Tyr Val Thr Glu Ala Thr Arg 
465                 470                 475                 480 


Val Gln Leu Val Leu Pro Leu Leu Val Ala Glu Ala Ala Ala Ala Pro 
                485                 490                 495     


Ala Phe Leu Glu Ala Phe Ala Ala Asn Val Leu Glu Pro Arg Glu His 
            500                 505                 510         


Ala Leu Leu Thr Leu Leu Leu Val Tyr Gly Pro Arg Glu Gly Gly Arg 
        515                 520                 525             


Gly Ala Pro Asp Pro Phe Leu Gly Val Lys Ala Ala Ala Ala Glu Leu 
    530                 535                 540                 


Glu Arg Arg Tyr Pro Gly Thr Arg Leu Ala Trp Leu Ala Val Arg Ala 
545                 550                 555                 560 


Glu Ala Pro Ser Gln Val Arg Leu Met Asp Val Val Ser Lys Lys His 
                565                 570                 575     


Pro Val Asp Thr Leu Phe Phe Leu Thr Thr Val Trp Thr Arg Pro Gly 
            580                 585                 590         


Pro Glu Val Leu Asn Arg Cys Arg Met Asn Ala Ile Ser Gly Trp Gln 
        595                 600                 605             


Ala Phe Phe Pro Val His Phe Gln Glu Phe Asn Pro Ala Leu Ser Pro 
    610                 615                 620                 


Gln Arg Ser Pro Pro Gly Pro Pro Gly Ala Gly Pro Asp Pro Pro Ser 
625                 630                 635                 640 


Pro Pro Gly Ala Asp Pro Ser Arg Gly Ala Pro Ile Gly Gly Arg Phe 
                645                 650                 655     


Asp Arg Gln Ala Ser Ala Glu Gly Cys Phe Tyr Asn Ala Asp Tyr Leu 
            660                 665                 670         


Ala Ala Arg Ala Arg Leu Ala Gly Glu Leu Ala Gly Gln Glu Glu Glu 
        675                 680                 685             


Glu Ala Leu Glu Gly Leu Glu Val Met Asp Val Phe Leu Arg Phe Ser 
    690                 695                 700                 


Gly Leu His Leu Phe Arg Ala Val Glu Pro Gly Leu Val Gln Lys Phe 
705                 710                 715                 720 


Ser Leu Arg Asp Cys Ser Pro Arg Leu Ser Glu Glu Leu Tyr His Arg 
                725                 730                 735     


Cys Arg Leu Ser Asn Leu Glu Gly Leu Gly Gly Arg Ala Gln Leu Ala 
            740                 745                 750         


Met Ala Leu Phe Glu Gln Glu Gln Ala Asn Ser Thr 
        755                 760                 


<210>  2842
<211>  772
<212>  PRT
<213>  Homo Sapiens

<400>  2842

Met Arg Leu Ser Ser Leu Leu Ala Leu Leu Arg Pro Ala Leu Pro Leu 
1               5                   10                  15      


Ile Leu Gly Leu Ser Leu Gly Cys Ser Leu Ser Leu Leu Arg Val Ser 
            20                  25                  30          


Trp Ile Gln Gly Glu Gly Glu Asp Pro Cys Val Glu Ala Val Gly Glu 
        35                  40                  45              


Arg Gly Gly Pro Gln Asn Pro Asp Ser Arg Ala Arg Leu Asp Gln Ser 
    50                  55                  60                  


Asp Glu Asp Phe Lys Pro Arg Ile Val Pro Tyr Tyr Arg Asp Pro Asn 
65                  70                  75                  80  


Lys Pro Tyr Lys Lys Val Leu Arg Thr Arg Tyr Ile Gln Thr Glu Leu 
                85                  90                  95      


Gly Ser Arg Glu Arg Leu Leu Val Ala Val Leu Thr Ser Arg Ala Thr 
            100                 105                 110         


Leu Ser Thr Leu Ala Val Ala Val Asn Arg Thr Val Ala His His Phe 
        115                 120                 125             


Pro Arg Leu Leu Tyr Phe Thr Gly Gln Arg Gly Ala Arg Ala Pro Ala 
    130                 135                 140                 


Gly Met Gln Val Val Ser His Gly Asp Glu Arg Pro Ala Trp Leu Met 
145                 150                 155                 160 


Ser Glu Thr Leu Arg His Leu His Thr His Phe Gly Ala Asp Tyr Asp 
                165                 170                 175     


Trp Phe Phe Ile Met Gln Asp Asp Thr Tyr Val Gln Ala Pro Arg Leu 
            180                 185                 190         


Ala Ala Leu Ala Gly His Leu Ser Ile Asn Gln Asp Leu Tyr Leu Gly 
        195                 200                 205             


Arg Ala Glu Glu Phe Ile Gly Ala Gly Glu Gln Ala Arg Tyr Cys His 
    210                 215                 220                 


Gly Gly Phe Gly Tyr Leu Leu Ser Arg Ser Leu Leu Leu Arg Leu Arg 
225                 230                 235                 240 


Pro His Leu Asp Gly Cys Arg Gly Asp Ile Leu Ser Ala Arg Pro Asp 
                245                 250                 255     


Glu Trp Leu Gly Arg Cys Leu Ile Asp Ser Leu Gly Val Gly Cys Val 
            260                 265                 270         


Ser Gln His Gln Gly Gln Gln Tyr Arg Ser Phe Glu Leu Ala Lys Asn 
        275                 280                 285             


Arg Asp Pro Glu Lys Glu Gly Ser Ser Ala Phe Leu Ser Ala Phe Ala 
    290                 295                 300                 


Val His Pro Val Ser Glu Gly Thr Leu Met Tyr Arg Leu His Lys Arg 
305                 310                 315                 320 


Phe Ser Ala Leu Glu Leu Glu Arg Ala Tyr Ser Glu Ile Glu Gln Leu 
                325                 330                 335     


Gln Ala Gln Ile Arg Asn Leu Thr Val Leu Thr Pro Glu Gly Glu Ala 
            340                 345                 350         


Gly Leu Ser Trp Pro Val Gly Leu Pro Ala Pro Phe Thr Pro His Ser 
        355                 360                 365             


Arg Phe Glu Val Leu Gly Trp Asp Tyr Phe Thr Glu Gln His Thr Phe 
    370                 375                 380                 


Ser Cys Ala Asp Gly Ala Pro Lys Cys Pro Leu Gln Gly Ala Ser Arg 
385                 390                 395                 400 


Ala Asp Val Gly Asp Ala Leu Glu Thr Ala Leu Glu Gln Leu Asn Arg 
                405                 410                 415     


Arg Tyr Gln Pro Arg Leu Arg Phe Gln Lys Gln Arg Leu Leu Asn Gly 
            420                 425                 430         


Tyr Arg Arg Phe Asp Pro Ala Arg Gly Met Glu Tyr Thr Leu Asp Leu 
        435                 440                 445             


Leu Leu Glu Cys Val Thr Gln Arg Gly His Arg Arg Ala Leu Ala Arg 
    450                 455                 460                 


Arg Val Ser Leu Leu Arg Pro Leu Ser Arg Val Glu Ile Leu Pro Met 
465                 470                 475                 480 


Pro Tyr Val Thr Glu Ala Thr Arg Val Gln Leu Val Leu Pro Leu Leu 
                485                 490                 495     


Val Ala Glu Ala Ala Ala Ala Pro Ala Phe Leu Glu Ala Phe Ala Ala 
            500                 505                 510         


Asn Val Leu Glu Pro Arg Glu His Ala Leu Leu Thr Leu Leu Leu Val 
        515                 520                 525             


Tyr Gly Pro Arg Glu Gly Gly Arg Gly Ala Pro Asp Pro Phe Leu Gly 
    530                 535                 540                 


Val Lys Ala Ala Ala Ala Glu Leu Glu Arg Arg Tyr Pro Gly Thr Arg 
545                 550                 555                 560 


Leu Ala Trp Leu Ala Val Arg Ala Glu Ala Pro Ser Gln Val Arg Leu 
                565                 570                 575     


Met Asp Val Val Ser Lys Lys His Pro Val Asp Thr Leu Phe Phe Leu 
            580                 585                 590         


Thr Thr Val Trp Thr Arg Pro Gly Pro Glu Val Leu Asn Arg Cys Arg 
        595                 600                 605             


Met Asn Ala Ile Ser Gly Trp Gln Ala Phe Phe Pro Val His Phe Gln 
    610                 615                 620                 


Glu Phe Asn Pro Ala Leu Ser Pro Gln Arg Ser Pro Pro Gly Pro Pro 
625                 630                 635                 640 


Gly Ala Gly Pro Asp Pro Pro Ser Pro Pro Gly Ala Asp Pro Ser Arg 
                645                 650                 655     


Gly Ala Pro Ile Gly Gly Arg Phe Asp Arg Gln Ala Ser Ala Glu Gly 
            660                 665                 670         


Cys Phe Tyr Asn Ala Asp Tyr Leu Ala Ala Arg Ala Arg Leu Ala Gly 
        675                 680                 685             


Glu Leu Ala Gly Gln Glu Glu Glu Glu Ala Leu Glu Gly Leu Glu Val 
    690                 695                 700                 


Met Asp Val Phe Leu Arg Phe Ser Gly Leu His Leu Phe Arg Ala Val 
705                 710                 715                 720 


Glu Pro Gly Leu Val Gln Lys Phe Ser Leu Arg Asp Cys Ser Pro Arg 
                725                 730                 735     


Leu Ser Glu Glu Leu Tyr His Arg Cys Arg Leu Ser Asn Leu Glu Gly 
            740                 745                 750         


Leu Gly Gly Arg Ala Gln Leu Ala Met Ala Leu Phe Glu Gln Glu Gln 
        755                 760                 765             


Ala Asn Ser Thr 
    770         


<210>  2843
<211>  86
<212>  PRT
<213>  Homo Sapiens

<400>  2843

Met Pro Ser Leu Pro Ala Pro Pro Ala Pro Leu Leu Leu Leu Gly Leu 
1               5                   10                  15      


Leu Leu Leu Gly Ser Arg Pro Ala Arg Gly Ala Gly Pro Glu Pro Pro 
            20                  25                  30          


Val Leu Pro Ile Arg Ser Glu Lys Glu Pro Leu Pro Val Arg Gly Ala 
        35                  40                  45              


Ala Gly Cys Thr Phe Gly Gly Lys Val Tyr Ala Leu Asp Glu Thr Trp 
    50                  55                  60                  


His Pro Asp Leu Gly Glu Pro Phe Gly Val Met Arg Cys Val Leu Cys 
65                  70                  75                  80  


Ala Cys Glu Ala Gly Pro 
                85      


<210>  2844
<211>  955
<212>  PRT
<213>  Homo Sapiens

<400>  2844

Met Pro Ser Leu Pro Ala Pro Pro Ala Pro Leu Leu Leu Leu Gly Leu 
1               5                   10                  15      


Leu Leu Leu Gly Ser Arg Pro Ala Arg Gly Ala Gly Pro Glu Pro Pro 
            20                  25                  30          


Val Leu Pro Ile Arg Ser Glu Lys Glu Pro Leu Pro Val Arg Gly Ala 
        35                  40                  45              


Ala Gly Cys Thr Phe Gly Gly Lys Val Tyr Ala Leu Asp Glu Thr Trp 
    50                  55                  60                  


His Pro Asp Leu Gly Glu Pro Phe Gly Val Met Arg Cys Val Leu Cys 
65                  70                  75                  80  


Ala Cys Glu Ala Pro Gln Trp Gly Arg Arg Thr Arg Gly Pro Gly Arg 
                85                  90                  95      


Val Ser Cys Lys Asn Ile Lys Pro Glu Cys Pro Thr Pro Ala Cys Gly 
            100                 105                 110         


Gln Pro Arg Gln Leu Pro Gly His Cys Cys Gln Thr Cys Pro Gln Glu 
        115                 120                 125             


Arg Ser Ser Ser Glu Arg Gln Pro Ser Gly Leu Ser Phe Glu Tyr Pro 
    130                 135                 140                 


Arg Asp Pro Glu His Arg Ser Tyr Ser Asp Arg Gly Glu Pro Gly Ala 
145                 150                 155                 160 


Glu Glu Arg Ala Arg Gly Asp Gly His Thr Asp Phe Val Ala Leu Leu 
                165                 170                 175     


Thr Gly Pro Arg Ser Gln Ala Val Ala Arg Ala Arg Val Ser Leu Leu 
            180                 185                 190         


Arg Ser Ser Leu Arg Phe Ser Ile Ser Tyr Arg Arg Leu Asp Arg Pro 
        195                 200                 205             


Thr Arg Ile Arg Phe Ser Asp Ser Asn Gly Ser Val Leu Phe Glu His 
    210                 215                 220                 


Pro Ala Ala Pro Thr Gln Asp Gly Leu Val Cys Gly Val Trp Arg Ala 
225                 230                 235                 240 


Val Pro Arg Leu Ser Leu Arg Leu Leu Arg Ala Glu Gln Leu His Val 
                245                 250                 255     


Ala Leu Val Thr Leu Thr His Pro Ser Gly Glu Val Trp Gly Pro Leu 
            260                 265                 270         


Ile Arg His Arg Ala Leu Ala Ala Glu Thr Phe Ser Ala Ile Leu Thr 
        275                 280                 285             


Leu Glu Gly Pro Pro Gln Gln Gly Val Gly Gly Ile Thr Leu Leu Thr 
    290                 295                 300                 


Leu Ser Asp Thr Glu Asp Ser Leu His Phe Leu Leu Leu Phe Arg Gly 
305                 310                 315                 320 


Leu Leu Glu Pro Arg Ser Gly Gly Leu Thr Gln Val Pro Leu Arg Leu 
                325                 330                 335     


Gln Ile Leu His Gln Gly Gln Leu Leu Arg Glu Leu Gln Ala Asn Val 
            340                 345                 350         


Ser Ala Gln Glu Pro Gly Phe Ala Glu Val Leu Pro Asn Leu Thr Val 
        355                 360                 365             


Gln Glu Met Asp Trp Leu Val Leu Gly Glu Leu Gln Met Ala Leu Glu 
    370                 375                 380                 


Trp Ala Gly Arg Pro Gly Leu Arg Ile Ser Gly His Ile Ala Ala Arg 
385                 390                 395                 400 


Lys Ser Cys Asp Val Leu Gln Ser Val Leu Cys Gly Ala Asp Ala Leu 
                405                 410                 415     


Ile Pro Val Gln Thr Gly Ala Ala Gly Ser Ala Ser Leu Thr Leu Leu 
            420                 425                 430         


Gly Asn Gly Ser Leu Ile Tyr Gln Val Gln Val Val Gly Thr Ser Ser 
        435                 440                 445             


Glu Val Val Ala Met Thr Leu Glu Thr Lys Pro Gln Arg Arg Asp Gln 
    450                 455                 460                 


Arg Thr Val Leu Cys His Met Ala Gly Leu Gln Pro Gly Gly His Thr 
465                 470                 475                 480 


Ala Val Gly Ile Cys Pro Gly Leu Gly Ala Arg Gly Ala His Met Leu 
                485                 490                 495     


Leu Gln Asn Glu Leu Phe Leu Asn Val Gly Thr Lys Asp Phe Pro Asp 
            500                 505                 510         


Gly Glu Leu Arg Gly His Val Ala Ala Leu Pro Tyr Cys Gly His Ser 
        515                 520                 525             


Ala Arg His Asp Thr Leu Pro Val Pro Leu Ala Gly Ala Leu Val Leu 
    530                 535                 540                 


Pro Pro Val Lys Ser Gln Ala Ala Gly His Ala Trp Leu Ser Leu Asp 
545                 550                 555                 560 


Thr His Cys His Leu His Tyr Glu Val Leu Leu Ala Gly Leu Gly Gly 
                565                 570                 575     


Ser Glu Gln Gly Thr Val Thr Ala His Leu Leu Gly Pro Pro Gly Thr 
            580                 585                 590         


Pro Gly Pro Arg Arg Leu Leu Lys Gly Phe Tyr Gly Ser Glu Ala Gln 
        595                 600                 605             


Gly Val Val Lys Asp Leu Glu Pro Glu Leu Leu Arg His Leu Ala Lys 
    610                 615                 620                 


Gly Met Ala Ser Leu Met Ile Thr Thr Lys Gly Ser Pro Arg Gly Glu 
625                 630                 635                 640 


Leu Arg Gly Gln Val His Ile Ala Asn Gln Cys Glu Val Gly Gly Leu 
                645                 650                 655     


Arg Leu Glu Ala Ala Gly Ala Glu Gly Val Arg Ala Leu Gly Ala Pro 
            660                 665                 670         


Asp Thr Ala Ser Ala Ala Pro Pro Val Val Pro Gly Leu Pro Ala Leu 
        675                 680                 685             


Ala Pro Ala Lys Pro Gly Gly Pro Gly Arg Pro Arg Asp Pro Asn Thr 
    690                 695                 700                 


Cys Phe Phe Glu Gly Gln Gln Arg Pro His Gly Ala Arg Trp Ala Pro 
705                 710                 715                 720 


Asn Tyr Asp Pro Leu Cys Ser Leu Cys Thr Cys Gln Arg Arg Thr Val 
                725                 730                 735     


Ile Cys Asp Pro Val Val Cys Pro Pro Pro Ser Cys Pro His Pro Val 
            740                 745                 750         


Gln Ala Pro Asp Gln Cys Cys Pro Val Cys Pro Glu Lys Gln Asp Val 
        755                 760                 765             


Arg Asp Leu Pro Gly Leu Pro Arg Ser Arg Asp Pro Gly Glu Gly Cys 
    770                 775                 780                 


Tyr Phe Asp Gly Asp Arg Ser Trp Arg Ala Ala Gly Thr Arg Trp His 
785                 790                 795                 800 


Pro Val Val Pro Pro Phe Gly Leu Ile Lys Cys Ala Val Cys Thr Cys 
                805                 810                 815     


Lys Gly Gly Thr Gly Glu Val His Cys Glu Lys Val Gln Cys Pro Arg 
            820                 825                 830         


Leu Ala Cys Ala Gln Pro Val Arg Val Asn Pro Thr Asp Cys Cys Lys 
        835                 840                 845             


Gln Cys Pro Val Gly Ser Gly Ala His Pro Gln Leu Gly Asp Pro Met 
    850                 855                 860                 


Gln Ala Asp Gly Pro Arg Gly Cys Arg Phe Ala Gly Gln Trp Phe Pro 
865                 870                 875                 880 


Glu Ser Gln Ser Trp His Pro Ser Val Pro Pro Phe Gly Glu Met Ser 
                885                 890                 895     


Cys Ile Thr Cys Arg Cys Gly Ala Gly Val Pro His Cys Glu Arg Asp 
            900                 905                 910         


Asp Cys Ser Leu Pro Leu Ser Cys Gly Ser Gly Lys Glu Ser Arg Cys 
        915                 920                 925             


Cys Ser Arg Cys Thr Ala His Arg Arg Pro Ala Pro Glu Thr Arg Thr 
    930                 935                 940                 


Asp Pro Glu Leu Glu Lys Glu Ala Glu Gly Ser 
945                 950                 955 


<210>  2845
<211>  915
<212>  PRT
<213>  Homo Sapiens

<400>  2845

Met Pro Ser Leu Pro Ala Pro Pro Ala Pro Leu Leu Leu Leu Gly Leu 
1               5                   10                  15      


Leu Leu Leu Gly Ser Arg Pro Ala Arg Gly Ala Gly Pro Glu Pro Pro 
            20                  25                  30          


Val Leu Pro Ile Arg Ser Glu Lys Glu Pro Leu Pro Val Arg Gly Ala 
        35                  40                  45              


Ala Gly Cys Thr Phe Gly Gly Lys Val Tyr Ala Leu Asp Glu Thr Trp 
    50                  55                  60                  


His Pro Asp Leu Gly Glu Pro Phe Gly Val Met Arg Cys Val Leu Cys 
65                  70                  75                  80  


Ala Cys Glu Ala Pro Gln Trp Gly Arg Arg Thr Arg Gly Pro Gly Arg 
                85                  90                  95      


Val Ser Cys Lys Asn Ile Lys Pro Glu Cys Pro Thr Pro Ala Cys Gly 
            100                 105                 110         


Gln Pro Arg Gln Leu Pro Gly His Cys Cys Gln Thr Cys Pro Gln Glu 
        115                 120                 125             


Arg Ser Ser Ser Glu Arg Gln Pro Ser Gly Leu Ser Phe Glu Tyr Pro 
    130                 135                 140                 


Arg Asp Pro Glu His Arg Ser Tyr Ser Asp Arg Gly Glu Pro Gly Ala 
145                 150                 155                 160 


Glu Glu Arg Ala Arg Gly Asp Gly His Thr Asp Phe Val Ala Leu Leu 
                165                 170                 175     


Thr Gly Pro Arg Ser Gln Ala Val Ala Arg Ala Arg Val Ser Leu Leu 
            180                 185                 190         


Arg Ser Ser Leu Arg Phe Ser Ile Ser Tyr Arg Arg Leu Asp Arg Pro 
        195                 200                 205             


Thr Arg Ile Arg Phe Ser Asp Ser Asn Gly Ser Val Leu Phe Glu His 
    210                 215                 220                 


Pro Ala Ala Pro Thr Gln Asp Gly Leu Val Cys Gly Val Trp Arg Ala 
225                 230                 235                 240 


Val Pro Arg Leu Ser Leu Arg Leu Leu Arg Ala Glu Gln Leu His Val 
                245                 250                 255     


Ala Leu Val Thr Leu Thr His Pro Ser Gly Glu Val Trp Gly Pro Leu 
            260                 265                 270         


Ile Arg His Arg Ala Leu Ala Ala Glu Thr Phe Ser Ala Ile Leu Thr 
        275                 280                 285             


Leu Glu Gly Pro Pro Gln Gln Gly Val Gly Gly Ile Thr Leu Leu Thr 
    290                 295                 300                 


Leu Ser Asp Thr Glu Asp Ser Leu His Phe Leu Leu Leu Phe Arg Gly 
305                 310                 315                 320 


Leu Leu Glu Pro Arg Ser Gly Gly Leu Thr Gln Val Pro Leu Arg Leu 
                325                 330                 335     


Gln Ile Leu His Gln Gly Gln Leu Leu Arg Glu Leu Gln Ala Asn Val 
            340                 345                 350         


Ser Ala Gln Glu Pro Gly Phe Ala Glu Val Leu Pro Asn Leu Thr Val 
        355                 360                 365             


Gln Glu Met Asp Trp Leu Val Leu Gly Glu Leu Gln Met Ala Leu Glu 
    370                 375                 380                 


Trp Ala Gly Arg Pro Gly Leu Arg Ile Ser Gly His Ile Ala Ala Arg 
385                 390                 395                 400 


Lys Ser Cys Asp Val Leu Gln Ser Val Leu Cys Gly Ala Asp Ala Leu 
                405                 410                 415     


Ile Pro Val Gln Thr Gly Ala Ala Gly Ser Ala Ser Leu Thr Leu Leu 
            420                 425                 430         


Gly Asn Gly Ser Leu Ile Tyr Gln Ala Val Gly Ile Cys Pro Gly Leu 
        435                 440                 445             


Gly Ala Arg Gly Ala His Met Leu Leu Gln Asn Glu Leu Phe Leu Asn 
    450                 455                 460                 


Val Gly Thr Lys Asp Phe Pro Asp Gly Glu Leu Arg Gly His Val Ala 
465                 470                 475                 480 


Ala Leu Pro Tyr Cys Gly His Ser Ala Arg His Asp Thr Leu Pro Val 
                485                 490                 495     


Pro Leu Ala Gly Ala Leu Val Leu Pro Pro Val Lys Ser Gln Ala Ala 
            500                 505                 510         


Gly His Ala Trp Leu Ser Leu Asp Thr His Cys His Leu His Tyr Glu 
        515                 520                 525             


Val Leu Leu Ala Gly Leu Gly Gly Ser Glu Gln Gly Thr Val Thr Ala 
    530                 535                 540                 


His Leu Leu Gly Pro Pro Gly Thr Pro Gly Pro Arg Arg Leu Leu Lys 
545                 550                 555                 560 


Gly Phe Tyr Gly Ser Glu Ala Gln Gly Val Val Lys Asp Leu Glu Pro 
                565                 570                 575     


Glu Leu Leu Arg His Leu Ala Lys Gly Met Ala Ser Leu Met Ile Thr 
            580                 585                 590         


Thr Lys Gly Ser Pro Arg Gly Glu Leu Arg Gly Gln Val His Ile Ala 
        595                 600                 605             


Asn Gln Cys Glu Val Gly Gly Leu Arg Leu Glu Ala Ala Gly Ala Glu 
    610                 615                 620                 


Gly Val Arg Ala Leu Gly Ala Pro Asp Thr Ala Ser Ala Ala Pro Pro 
625                 630                 635                 640 


Val Val Pro Gly Leu Pro Ala Leu Ala Pro Ala Lys Pro Gly Gly Pro 
                645                 650                 655     


Gly Arg Pro Arg Asp Pro Asn Thr Cys Phe Phe Glu Gly Gln Gln Arg 
            660                 665                 670         


Pro His Gly Ala Arg Trp Ala Pro Asn Tyr Asp Pro Leu Cys Ser Leu 
        675                 680                 685             


Cys Thr Cys Gln Arg Arg Thr Val Ile Cys Asp Pro Val Val Cys Pro 
    690                 695                 700                 


Pro Pro Ser Cys Pro His Pro Val Gln Ala Pro Asp Gln Cys Cys Pro 
705                 710                 715                 720 


Val Cys Pro Glu Lys Gln Asp Val Arg Asp Leu Pro Gly Leu Pro Arg 
                725                 730                 735     


Ser Arg Asp Pro Gly Glu Gly Cys Tyr Phe Asp Gly Asp Arg Ser Trp 
            740                 745                 750         


Arg Ala Ala Gly Thr Arg Trp His Pro Val Val Pro Pro Phe Gly Leu 
        755                 760                 765             


Ile Lys Cys Ala Val Cys Thr Cys Lys Gly Gly Thr Gly Glu Val His 
    770                 775                 780                 


Cys Glu Lys Val Gln Cys Pro Arg Leu Ala Cys Ala Gln Pro Val Arg 
785                 790                 795                 800 


Val Asn Pro Thr Asp Cys Cys Lys Gln Cys Pro Val Gly Ser Gly Ala 
                805                 810                 815     


His Pro Gln Leu Gly Asp Pro Met Gln Ala Asp Gly Pro Arg Gly Cys 
            820                 825                 830         


Arg Phe Ala Gly Gln Trp Phe Pro Glu Ser Gln Ser Trp His Pro Ser 
        835                 840                 845             


Val Pro Pro Phe Gly Glu Met Ser Cys Ile Thr Cys Arg Cys Gly Ala 
    850                 855                 860                 


Gly Val Pro His Cys Glu Arg Asp Asp Cys Ser Leu Pro Leu Ser Cys 
865                 870                 875                 880 


Gly Ser Gly Lys Glu Ser Arg Cys Cys Ser Arg Cys Thr Ala His Arg 
                885                 890                 895     


Arg Pro Ala Pro Glu Thr Arg Thr Asp Pro Glu Leu Glu Lys Glu Ala 
            900                 905                 910         


Glu Gly Ser 
        915 


<210>  2846
<211>  350
<212>  PRT
<213>  Homo Sapiens

<400>  2846

Met Pro Ser Leu Pro Ala Pro Pro Ala Pro Leu Leu Leu Leu Gly Leu 
1               5                   10                  15      


Leu Leu Leu Gly Ser Arg Pro Ala Arg Gly Ala Gly Pro Glu Pro Pro 
            20                  25                  30          


Val Leu Pro Ile Arg Ser Glu Lys Glu Pro Leu Pro Val Arg Gly Ala 
        35                  40                  45              


Ala Gly Cys Thr Phe Gly Gly Lys Val Tyr Ala Leu Asp Glu Thr Trp 
    50                  55                  60                  


His Pro Asp Leu Gly Glu Pro Phe Gly Val Met Arg Cys Val Leu Cys 
65                  70                  75                  80  


Ala Cys Glu Ala Pro Gln Trp Gly Arg Arg Thr Arg Gly Pro Gly Arg 
                85                  90                  95      


Val Ser Cys Lys Asn Ile Lys Pro Glu Cys Pro Thr Pro Ala Cys Gly 
            100                 105                 110         


Gln Pro Arg Gln Leu Pro Gly His Cys Cys Gln Thr Cys Pro Gln Glu 
        115                 120                 125             


Arg Ser Ser Ser Glu Arg Gln Pro Ser Gly Leu Ser Phe Glu Tyr Pro 
    130                 135                 140                 


Arg Asp Pro Glu His Arg Ser Tyr Ser Asp Arg Gly Glu Pro Gly Ala 
145                 150                 155                 160 


Glu Glu Arg Ala Arg Gly Asp Gly His Thr Asp Phe Val Ala Leu Leu 
                165                 170                 175     


Thr Gly Pro Arg Ser Gln Ala Val Ala Arg Ala Arg Val Ser Leu Leu 
            180                 185                 190         


Arg Ser Ser Leu Arg Phe Ser Ile Ser Tyr Arg Arg Leu Asp Arg Pro 
        195                 200                 205             


Thr Arg Ile Arg Phe Ser Asp Ser Asn Gly Ser Val Leu Phe Glu His 
    210                 215                 220                 


Pro Ala Ala Pro Thr Gln Asp Gly Leu Val Cys Gly Val Trp Arg Ala 
225                 230                 235                 240 


Val Pro Arg Leu Ser Leu Arg Leu Leu Arg Ala Glu Gln Leu His Val 
                245                 250                 255     


Ala Leu Val Thr Leu Thr His Pro Ser Gly Glu Val Trp Gly Pro Leu 
            260                 265                 270         


Ile Arg His Arg Ala Leu Ala Ala Glu Thr Phe Ser Ala Ile Leu Thr 
        275                 280                 285             


Leu Glu Gly Pro Pro Gln Gln Gly Val Gly Gly Ile Thr Leu Leu Thr 
    290                 295                 300                 


Leu Ser Asp Thr Glu Asp Ser Leu His Phe Leu Leu Leu Phe Arg Gly 
305                 310                 315                 320 


Leu Leu Glu Pro Arg Ser Gly Asp Ser Thr Pro Gly Ala Ala Thr Ala 
                325                 330                 335     


Arg Thr Ser Gly Gln Cys Leu Ser Pro Gly Thr Arg Leu Cys 
            340                 345                 350 


<210>  2847
<211>  954
<212>  PRT
<213>  Homo Sapiens

<400>  2847

Met Pro Ser Leu Pro Ala Pro Pro Ala Pro Leu Leu Leu Leu Gly Leu 
1               5                   10                  15      


Leu Leu Leu Gly Ser Arg Pro Ala Arg Gly Ala Gly Pro Glu Pro Pro 
            20                  25                  30          


Val Leu Pro Ile Arg Ser Glu Lys Glu Pro Leu Pro Val Arg Gly Ala 
        35                  40                  45              


Ala Gly Cys Thr Phe Gly Gly Lys Val Tyr Ala Leu Asp Glu Thr Trp 
    50                  55                  60                  


His Pro Asp Leu Gly Glu Pro Phe Gly Val Met Arg Cys Val Leu Cys 
65                  70                  75                  80  


Ala Cys Glu Ala Pro Gln Trp Gly Arg Arg Thr Arg Gly Pro Gly Arg 
                85                  90                  95      


Val Ser Cys Lys Asn Ile Lys Pro Glu Cys Pro Thr Pro Ala Cys Gly 
            100                 105                 110         


Gln Pro Arg Gln Leu Pro Gly His Cys Cys Gln Thr Cys Pro Gln Glu 
        115                 120                 125             


Arg Ser Ser Ser Glu Arg Gln Pro Ser Gly Leu Ser Phe Glu Tyr Pro 
    130                 135                 140                 


Arg Asp Pro Glu His Arg Ser Tyr Ser Asp Arg Gly Glu Pro Gly Ala 
145                 150                 155                 160 


Glu Glu Arg Ala Arg Gly Asp Gly His Thr Asp Phe Val Ala Leu Leu 
                165                 170                 175     


Thr Gly Pro Arg Ser Gln Ala Val Ala Arg Ala Arg Val Ser Leu Leu 
            180                 185                 190         


Arg Ser Ser Leu Arg Phe Ser Ile Ser Tyr Arg Arg Leu Asp Arg Pro 
        195                 200                 205             


Thr Arg Ile Arg Phe Ser Asp Ser Asn Gly Ser Val Leu Phe Glu His 
    210                 215                 220                 


Pro Ala Ala Pro Thr Gln Asp Gly Leu Val Cys Gly Val Trp Arg Ala 
225                 230                 235                 240 


Val Pro Arg Leu Ser Leu Arg Leu Leu Arg Ala Glu Gln Leu His Val 
                245                 250                 255     


Ala Leu Val Thr Leu Thr His Pro Ser Gly Glu Val Trp Gly Pro Leu 
            260                 265                 270         


Ile Arg His Arg Ala Leu Ala Ala Glu Thr Phe Ser Ala Ile Leu Thr 
        275                 280                 285             


Leu Glu Gly Pro Pro Gln Gln Gly Val Gly Gly Ile Thr Leu Leu Thr 
    290                 295                 300                 


Leu Ser Asp Thr Glu Asp Ser Leu His Phe Leu Leu Leu Phe Arg Gly 
305                 310                 315                 320 


Leu Leu Glu Pro Arg Ser Gly Gly Leu Thr Gln Val Pro Leu Arg Leu 
                325                 330                 335     


Gln Ile Leu His Gln Gly Gln Leu Leu Arg Glu Leu Gln Ala Asn Val 
            340                 345                 350         


Ser Ala Gln Glu Pro Gly Phe Ala Glu Val Leu Pro Asn Leu Thr Val 
        355                 360                 365             


Gln Glu Met Asp Trp Leu Val Leu Gly Glu Leu Gln Met Ala Leu Glu 
    370                 375                 380                 


Trp Ala Gly Arg Pro Gly Leu Arg Ile Ser Gly His Ile Ala Ala Arg 
385                 390                 395                 400 


Lys Ser Cys Asp Val Leu Gln Ser Val Leu Cys Gly Ala Asp Ala Leu 
                405                 410                 415     


Ile Pro Val Gln Thr Gly Ala Ala Gly Ser Ala Ser Leu Thr Leu Leu 
            420                 425                 430         


Gly Asn Gly Ser Leu Ile Tyr Gln Val Gln Val Val Gly Thr Ser Ser 
        435                 440                 445             


Glu Val Val Ala Met Thr Leu Glu Thr Lys Pro Gln Arg Arg Asp Gln 
    450                 455                 460                 


Arg Thr Val Leu Cys His Met Ala Gly Leu Gln Pro Gly Gly His Thr 
465                 470                 475                 480 


Ala Val Gly Ile Cys Pro Gly Leu Gly Ala Arg Gly Ala His Met Leu 
                485                 490                 495     


Leu Gln Asn Glu Leu Phe Leu Asn Val Gly Thr Lys Asp Phe Pro Asp 
            500                 505                 510         


Gly Glu Leu Arg Gly His Val Ala Ala Leu Pro Tyr Cys Gly His Ser 
        515                 520                 525             


Ala Arg His Asp Thr Leu Pro Val Pro Leu Ala Gly Ala Leu Val Leu 
    530                 535                 540                 


Pro Pro Val Lys Ser Gln Ala Ala Gly His Ala Trp Leu Ser Leu Asp 
545                 550                 555                 560 


Thr His Cys His Leu His Tyr Glu Val Leu Leu Ala Gly Leu Gly Gly 
                565                 570                 575     


Ser Glu Gln Gly Thr Val Thr Ala His Leu Leu Gly Pro Pro Gly Thr 
            580                 585                 590         


Pro Gly Pro Arg Arg Leu Leu Lys Gly Phe Tyr Gly Ser Glu Ala Gln 
        595                 600                 605             


Gly Val Val Lys Asp Leu Glu Pro Glu Leu Leu Arg His Leu Ala Lys 
    610                 615                 620                 


Gly Met Ala Ser Leu Met Ile Thr Thr Lys Gly Ser Pro Arg Gly Glu 
625                 630                 635                 640 


Leu Arg Gly Gln Val His Ile Ala Asn Gln Cys Glu Val Gly Gly Leu 
                645                 650                 655     


Arg Leu Glu Ala Ala Gly Ala Glu Gly Val Arg Ala Leu Gly Ala Pro 
            660                 665                 670         


Asp Thr Ala Ser Ala Ala Pro Pro Val Val Pro Gly Leu Pro Ala Leu 
        675                 680                 685             


Ala Pro Ala Lys Pro Gly Gly Pro Gly Arg Pro Arg Asp Pro Asn Thr 
    690                 695                 700                 


Cys Phe Phe Glu Gly Gln Gln Arg Pro His Gly Ala Arg Trp Ala Pro 
705                 710                 715                 720 


Asn Tyr Asp Pro Leu Cys Ser Leu Cys Thr Cys Gln Arg Arg Thr Val 
                725                 730                 735     


Ile Cys Asp Pro Val Val Cys Pro Pro Pro Ser Cys Pro His Pro Val 
            740                 745                 750         


Gln Ala Pro Asp Gln Cys Cys Pro Val Cys Pro Glu Lys Gln Asp Val 
        755                 760                 765             


Arg Asp Leu Pro Gly Leu Pro Arg Ser Arg Asp Pro Gly Glu Gly Cys 
    770                 775                 780                 


Tyr Phe Asp Gly Asp Arg Ser Trp Arg Ala Ala Gly Thr Arg Trp His 
785                 790                 795                 800 


Pro Val Val Pro Pro Phe Gly Leu Ile Lys Cys Ala Val Cys Thr Cys 
                805                 810                 815     


Lys Gly Gly Thr Gly Glu Val His Cys Glu Lys Val Gln Cys Pro Arg 
            820                 825                 830         


Leu Ala Cys Ala Gln Pro Val Arg Val Asn Pro Thr Asp Cys Cys Lys 
        835                 840                 845             


Gln Cys Pro Val Gly Ser Gly Ala His Pro Gln Leu Gly Asp Pro Met 
    850                 855                 860                 


Gln Ala Asp Gly Pro Arg Gly Cys Arg Phe Ala Gly Gln Trp Phe Pro 
865                 870                 875                 880 


Glu Ser Gln Ser Trp His Pro Ser Val Pro Pro Phe Gly Glu Met Ser 
                885                 890                 895     


Cys Ile Thr Cys Arg Cys Gly Ala Gly Val Pro His Cys Glu Arg Asp 
            900                 905                 910         


Asp Cys Ser Leu Pro Leu Ser Cys Gly Ser Gly Lys Glu Ser Arg Cys 
        915                 920                 925             


Cys Ser Arg Cys Thr Ala His Arg Arg Pro Pro Glu Thr Arg Thr Asp 
    930                 935                 940                 


Pro Glu Leu Glu Lys Glu Ala Glu Gly Ser 
945                 950                 


<210>  2848
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  2848

Met Pro Ser Leu Pro Ala Pro Pro Ala Pro Leu Leu Leu Leu Gly Leu 
1               5                   10                  15      


Leu Leu Leu Gly Ser Arg Pro Ala Arg Gly Ala Gly Pro Glu Pro Pro 
            20                  25                  30          


Val Leu Pro Ile Arg Ser Glu Lys Glu Pro Leu Pro Val Arg Gly Ala 
        35                  40                  45              


Ala Gly Cys Thr Phe Gly Gly Lys Val Tyr Ala Leu Asp Glu Thr Trp 
    50                  55                  60                  


His Pro Asp Leu Gly Glu Pro Phe Gly Val Met Arg Cys Val Leu Cys 
65                  70                  75                  80  


Ala Cys Glu Ala Thr Gly Thr Leu Arg Pro Arg Glu Met Lys 
                85                  90                  


<210>  2849
<211>  450
<212>  PRT
<213>  Homo Sapiens

<400>  2849

Met Gly Gly Met Lys Tyr Ile Phe Ser Leu Leu Phe Phe Leu Leu Leu 
1               5                   10                  15      


Glu Gly Gly Lys Thr Glu Gln Val Lys His Ser Glu Thr Tyr Cys Met 
            20                  25                  30          


Phe Gln Asp Lys Lys Tyr Arg Val Gly Glu Arg Trp His Pro Tyr Leu 
        35                  40                  45              


Glu Pro Tyr Gly Leu Val Tyr Cys Val Asn Cys Ile Cys Ser Glu Asn 
    50                  55                  60                  


Gly Asn Val Leu Cys Ser Arg Val Arg Cys Pro Asn Val His Cys Leu 
65                  70                  75                  80  


Ser Pro Val His Ile Pro His Leu Cys Cys Pro Arg Cys Pro Asp Ser 
                85                  90                  95      


Leu Pro Pro Val Asn Asn Lys Val Thr Ser Lys Ser Cys Glu Tyr Asn 
            100                 105                 110         


Gly Thr Thr Tyr Gln His Gly Glu Leu Phe Val Ala Glu Gly Leu Phe 
        115                 120                 125             


Gln Asn Arg Gln Pro Asn Gln Cys Thr Gln Cys Ser Cys Ser Glu Gly 
    130                 135                 140                 


Asn Val Tyr Cys Gly Leu Lys Thr Cys Pro Lys Leu Thr Cys Ala Phe 
145                 150                 155                 160 


Pro Val Ser Val Pro Asp Ser Cys Cys Arg Val Cys Arg Gly Asp Gly 
                165                 170                 175     


Glu Leu Ser Trp Glu His Ser Asp Gly Asp Ile Phe Arg Gln Pro Ala 
            180                 185                 190         


Asn Arg Glu Ala Arg His Ser Tyr His Arg Ser His Tyr Asp Pro Pro 
        195                 200                 205             


Pro Ser Arg Gln Ala Gly Gly Leu Ser Arg Phe Pro Gly Ala Arg Ser 
    210                 215                 220                 


His Arg Gly Ala Leu Met Asp Ser Gln Gln Ala Ser Gly Thr Ile Val 
225                 230                 235                 240 


Gln Ile Val Ile Asn Asn Lys His Lys His Gly Gln Val Cys Val Ser 
                245                 250                 255     


Asn Gly Lys Thr Tyr Ser His Gly Glu Ser Trp His Pro Asn Leu Arg 
            260                 265                 270         


Ala Phe Gly Ile Val Glu Cys Val Leu Cys Thr Cys Asn Val Thr Lys 
        275                 280                 285             


Gln Glu Cys Lys Lys Ile His Cys Pro Asn Arg Tyr Pro Cys Lys Tyr 
    290                 295                 300                 


Pro Gln Lys Ile Asp Gly Lys Cys Cys Lys Val Cys Pro Gly Lys Lys 
305                 310                 315                 320 


Ala Lys Glu Leu Pro Gly Gln Ser Phe Asp Asn Lys Gly Tyr Phe Cys 
                325                 330                 335     


Gly Glu Glu Thr Met Pro Val Tyr Glu Ser Val Phe Met Glu Asp Gly 
            340                 345                 350         


Glu Thr Thr Arg Lys Ile Ala Leu Glu Thr Glu Arg Pro Pro Gln Val 
        355                 360                 365             


Glu Val His Val Trp Thr Ile Arg Lys Gly Ile Leu Gln His Phe His 
    370                 375                 380                 


Ile Glu Lys Ile Ser Lys Arg Met Phe Glu Glu Leu Pro His Phe Lys 
385                 390                 395                 400 


Leu Val Thr Arg Thr Thr Leu Ser Gln Trp Lys Ile Phe Thr Glu Gly 
                405                 410                 415     


Glu Ala Gln Ile Ser Gln Met Cys Ser Ser Arg Val Cys Arg Thr Glu 
            420                 425                 430         


Leu Glu Asp Leu Val Lys Val Leu Tyr Leu Glu Arg Ser Glu Lys Gly 
        435                 440                 445             


His Cys 
    450 


<210>  2850
<211>  456
<212>  PRT
<213>  Homo Sapiens

<400>  2850

Met Arg Lys Lys Trp Lys Met Gly Gly Met Lys Tyr Ile Phe Ser Leu 
1               5                   10                  15      


Leu Phe Phe Leu Leu Leu Glu Gly Gly Lys Thr Glu Gln Val Lys His 
            20                  25                  30          


Ser Glu Thr Tyr Cys Met Phe Gln Asp Lys Lys Tyr Arg Val Gly Glu 
        35                  40                  45              


Arg Trp His Pro Tyr Leu Glu Pro Tyr Gly Leu Val Tyr Cys Val Asn 
    50                  55                  60                  


Cys Ile Cys Ser Glu Asn Gly Asn Val Leu Cys Ser Arg Val Arg Cys 
65                  70                  75                  80  


Pro Asn Val His Cys Leu Ser Pro Val His Ile Pro His Leu Cys Cys 
                85                  90                  95      


Pro Arg Cys Pro Asp Ser Leu Pro Pro Val Asn Asn Lys Val Thr Ser 
            100                 105                 110         


Lys Ser Cys Glu Tyr Asn Gly Thr Thr Tyr Gln His Gly Glu Leu Phe 
        115                 120                 125             


Val Ala Glu Gly Leu Phe Gln Asn Arg Gln Pro Asn Gln Cys Thr Gln 
    130                 135                 140                 


Cys Ser Cys Ser Glu Gly Asn Val Tyr Cys Gly Leu Lys Thr Cys Pro 
145                 150                 155                 160 


Lys Leu Thr Cys Ala Phe Pro Val Ser Val Pro Asp Ser Cys Cys Arg 
                165                 170                 175     


Val Cys Arg Gly Asp Gly Glu Leu Ser Trp Glu His Ser Asp Gly Asp 
            180                 185                 190         


Ile Phe Arg Gln Pro Ala Asn Arg Glu Ala Arg His Ser Tyr His Arg 
        195                 200                 205             


Ser His Tyr Asp Pro Pro Pro Ser Arg Gln Ala Gly Gly Leu Ser Arg 
    210                 215                 220                 


Phe Pro Gly Ala Arg Ser His Arg Gly Ala Leu Met Asp Ser Gln Gln 
225                 230                 235                 240 


Ala Ser Gly Thr Ile Val Gln Ile Val Ile Asn Asn Lys His Lys His 
                245                 250                 255     


Gly Gln Val Cys Val Ser Asn Gly Lys Thr Tyr Ser His Gly Glu Ser 
            260                 265                 270         


Trp His Pro Asn Leu Arg Ala Phe Gly Ile Val Glu Cys Val Leu Cys 
        275                 280                 285             


Thr Cys Asn Val Thr Lys Gln Glu Cys Lys Lys Ile His Cys Pro Asn 
    290                 295                 300                 


Arg Tyr Pro Cys Lys Tyr Pro Gln Lys Ile Asp Gly Lys Cys Cys Lys 
305                 310                 315                 320 


Val Cys Pro Gly Lys Lys Ala Lys Glu Leu Pro Gly Gln Ser Phe Asp 
                325                 330                 335     


Asn Lys Gly Tyr Phe Cys Gly Glu Glu Thr Met Pro Val Tyr Glu Ser 
            340                 345                 350         


Val Phe Met Glu Asp Gly Glu Thr Thr Arg Lys Ile Ala Leu Glu Thr 
        355                 360                 365             


Glu Arg Pro Pro Gln Val Glu Val His Val Trp Thr Ile Arg Lys Gly 
    370                 375                 380                 


Ile Leu Gln His Phe His Ile Glu Lys Ile Ser Lys Arg Met Phe Glu 
385                 390                 395                 400 


Glu Leu Pro His Phe Lys Leu Val Thr Arg Thr Thr Leu Ser Gln Trp 
                405                 410                 415     


Lys Ile Phe Thr Glu Gly Glu Ala Gln Ile Ser Gln Met Cys Ser Ser 
            420                 425                 430         


Arg Val Cys Arg Thr Glu Leu Glu Asp Leu Val Lys Val Leu Tyr Leu 
        435                 440                 445             


Glu Arg Ser Glu Lys Gly His Cys 
    450                 455     


<210>  2851
<211>  457
<212>  PRT
<213>  Homo Sapiens

<400>  2851

Met Arg Lys Lys Trp Lys Met Gly Gly Met Lys Tyr Ile Phe Ser Leu 
1               5                   10                  15      


Leu Phe Phe Leu Leu Leu Glu Gly Gly Lys Thr Glu Gln Val Lys His 
            20                  25                  30          


Ser Glu Thr Tyr Cys Met Phe Gln Asp Lys Lys Tyr Arg Val Gly Glu 
        35                  40                  45              


Arg Trp His Pro Tyr Leu Glu Pro Tyr Gly Leu Val Tyr Cys Val Asn 
    50                  55                  60                  


Cys Ile Cys Ser Glu Asn Gly Asn Val Leu Cys Ser Arg Val Arg Cys 
65                  70                  75                  80  


Pro Asn Val His Cys Leu Ser Pro Val His Ile Pro His Leu Cys Cys 
                85                  90                  95      


Pro Arg Cys Pro Asp Ser Leu Pro Pro Val Asn Asn Lys Val Thr Ser 
            100                 105                 110         


Lys Ser Cys Glu Tyr Asn Gly Thr Thr Tyr Gln His Gly Glu Leu Phe 
        115                 120                 125             


Val Ala Glu Gly Leu Phe Gln Asn Arg Gln Pro Asn Gln Cys Thr Gln 
    130                 135                 140                 


Cys Ser Cys Ser Glu Gly Asn Val Tyr Cys Gly Leu Lys Thr Cys Pro 
145                 150                 155                 160 


Lys Leu Thr Cys Ala Phe Pro Val Ser Val Pro Asp Ser Cys Cys Arg 
                165                 170                 175     


Val Cys Arg Gly Asp Gly Glu Leu Ser Trp Glu His Ser Asp Gly Asp 
            180                 185                 190         


Ile Phe Arg Gln Pro Ala Asn Arg Glu Ala Arg His Ser Tyr His Arg 
        195                 200                 205             


Ser His Tyr Asp Pro Pro Pro Ser Arg Gln Ala Gly Gly Leu Ser Arg 
    210                 215                 220                 


Phe Pro Gly Ala Arg Ser His Arg Gly Ala Leu Met Asp Ser Gln Gln 
225                 230                 235                 240 


Ala Ser Gly Thr Ile Val Gln Ile Val Ile Asn Asn Lys His Lys His 
                245                 250                 255     


Gly Gln Val Cys Val Ser Asn Gly Lys Thr Tyr Ser His Gly Glu Ser 
            260                 265                 270         


Trp His Pro Asn Leu Arg Ala Phe Gly Ile Val Glu Cys Val Leu Cys 
        275                 280                 285             


Thr Cys Asn Val Thr Lys Gln Glu Cys Lys Lys Ile His Cys Pro Asn 
    290                 295                 300                 


Arg Tyr Pro Cys Lys Tyr Pro Gln Lys Ile Asp Gly Lys Cys Cys Lys 
305                 310                 315                 320 


Val Cys Pro Gly Lys Lys Ala Lys Glu Glu Leu Pro Gly Gln Ser Phe 
                325                 330                 335     


Asp Asn Lys Gly Tyr Phe Cys Gly Glu Glu Thr Met Pro Val Tyr Glu 
            340                 345                 350         


Ser Val Phe Met Glu Asp Gly Glu Thr Thr Arg Lys Ile Ala Leu Glu 
        355                 360                 365             


Thr Glu Arg Pro Pro Gln Val Glu Val His Val Trp Thr Ile Arg Lys 
    370                 375                 380                 


Gly Ile Leu Gln His Phe His Ile Glu Lys Ile Ser Lys Arg Met Phe 
385                 390                 395                 400 


Glu Glu Leu Pro His Phe Lys Leu Val Thr Arg Thr Thr Leu Ser Gln 
                405                 410                 415     


Trp Lys Ile Phe Thr Glu Gly Glu Ala Gln Ile Ser Gln Met Cys Ser 
            420                 425                 430         


Ser Arg Val Cys Arg Thr Glu Leu Glu Asp Leu Val Lys Val Leu Tyr 
        435                 440                 445             


Leu Glu Arg Ser Glu Lys Gly His Cys 
    450                 455         


<210>  2852
<211>  458
<212>  PRT
<213>  Homo Sapiens

<400>  2852

Met Arg Lys Lys Trp Lys Met Gly Gly Met Lys Tyr Ile Phe Ser Leu 
1               5                   10                  15      


Leu Phe Phe Leu Leu Leu Glu Gly Gly Lys Thr Glu Gln Val Lys His 
            20                  25                  30          


Ser Glu Thr Tyr Cys Met Phe Gln Asp Lys Lys Tyr Arg Val Gly Glu 
        35                  40                  45              


Arg Trp His Pro Tyr Leu Glu Pro Tyr Gly Leu Val Tyr Cys Val Asn 
    50                  55                  60                  


Cys Ile Cys Ser Glu Asn Gly Asn Val Leu Cys Ser Arg Val Arg Cys 
65                  70                  75                  80  


Pro Asn Val His Cys Leu Ser Pro Val His Ile Pro His Leu Cys Cys 
                85                  90                  95      


Pro Arg Cys Pro Glu Asp Ser Leu Pro Pro Val Asn Asn Lys Val Thr 
            100                 105                 110         


Ser Lys Ser Cys Glu Tyr Asn Gly Thr Thr Tyr Gln His Gly Glu Leu 
        115                 120                 125             


Phe Val Ala Glu Gly Leu Phe Gln Asn Arg Gln Pro Asn Gln Cys Thr 
    130                 135                 140                 


Gln Cys Ser Cys Ser Glu Gly Asn Val Tyr Cys Gly Leu Lys Thr Cys 
145                 150                 155                 160 


Pro Lys Leu Thr Cys Ala Phe Pro Val Ser Val Pro Asp Ser Cys Cys 
                165                 170                 175     


Arg Val Cys Arg Gly Asp Gly Glu Leu Ser Trp Glu His Ser Asp Gly 
            180                 185                 190         


Asp Ile Phe Arg Gln Pro Ala Asn Arg Glu Ala Arg His Ser Tyr His 
        195                 200                 205             


Arg Ser His Tyr Asp Pro Pro Pro Ser Arg Gln Ala Gly Gly Leu Ser 
    210                 215                 220                 


Arg Phe Pro Gly Ala Arg Ser His Arg Gly Ala Leu Met Asp Ser Gln 
225                 230                 235                 240 


Gln Ala Ser Gly Thr Ile Val Gln Ile Val Ile Asn Asn Lys His Lys 
                245                 250                 255     


His Gly Gln Val Cys Val Ser Asn Gly Lys Thr Tyr Ser His Gly Glu 
            260                 265                 270         


Ser Trp His Pro Asn Leu Arg Ala Phe Gly Ile Val Glu Cys Val Leu 
        275                 280                 285             


Cys Thr Cys Asn Val Thr Lys Gln Glu Cys Lys Lys Ile His Cys Pro 
    290                 295                 300                 


Asn Arg Tyr Pro Cys Lys Tyr Pro Gln Lys Ile Asp Gly Lys Cys Cys 
305                 310                 315                 320 


Lys Val Cys Pro Gly Lys Lys Ala Lys Glu Glu Leu Pro Gly Gln Ser 
                325                 330                 335     


Phe Asp Asn Lys Gly Tyr Phe Cys Gly Glu Glu Thr Met Pro Val Tyr 
            340                 345                 350         


Glu Ser Val Phe Met Glu Asp Gly Glu Thr Thr Arg Lys Ile Ala Leu 
        355                 360                 365             


Glu Thr Glu Arg Pro Pro Gln Val Glu Val His Val Trp Thr Ile Arg 
    370                 375                 380                 


Lys Gly Ile Leu Gln His Phe His Ile Glu Lys Ile Ser Lys Arg Met 
385                 390                 395                 400 


Phe Glu Glu Leu Pro His Phe Lys Leu Val Thr Arg Thr Thr Leu Ser 
                405                 410                 415     


Gln Trp Lys Ile Phe Thr Glu Gly Glu Ala Gln Ile Ser Gln Met Cys 
            420                 425                 430         


Ser Ser Arg Val Cys Arg Thr Glu Leu Glu Asp Leu Val Lys Val Leu 
        435                 440                 445             


Tyr Leu Glu Arg Ser Glu Lys Gly His Cys 
    450                 455             


<210>  2853
<211>  378
<212>  PRT
<213>  Homo Sapiens

<400>  2853

Met Arg Lys Lys Trp Lys Met Gly Gly Met Lys Tyr Ile Phe Ser Leu 
1               5                   10                  15      


Leu Phe Phe Leu Leu Leu Glu Gly Gly Lys Thr Glu Gln Val Lys His 
            20                  25                  30          


Ser Glu Thr Tyr Cys Met Phe Gln Asp Lys Lys Tyr Arg Val Gly Glu 
        35                  40                  45              


Arg Trp His Pro Tyr Leu Glu Pro Tyr Gly Leu Val Tyr Cys Val Asn 
    50                  55                  60                  


Cys Ile Cys Ser Glu Asn Gly Asn Val Leu Cys Ser Arg Val Arg Cys 
65                  70                  75                  80  


Pro Asn Val His Cys Leu Ser Pro Val His Ile Pro His Leu Cys Cys 
                85                  90                  95      


Pro Arg Cys Pro Gly Asp Gly Glu Leu Ser Trp Glu His Ser Asp Gly 
            100                 105                 110         


Asp Ile Phe Arg Gln Pro Ala Asn Arg Glu Ala Arg His Ser Tyr His 
        115                 120                 125             


Arg Ser His Tyr Asp Pro Pro Pro Ser Arg Gln Ala Gly Gly Leu Ser 
    130                 135                 140                 


Arg Phe Pro Gly Ala Arg Ser His Arg Gly Ala Leu Met Asp Ser Gln 
145                 150                 155                 160 


Gln Ala Ser Gly Thr Ile Val Gln Ile Val Ile Asn Asn Lys His Lys 
                165                 170                 175     


His Gly Gln Val Cys Val Ser Asn Gly Lys Thr Tyr Ser His Gly Glu 
            180                 185                 190         


Ser Trp His Pro Asn Leu Arg Ala Phe Gly Ile Val Glu Cys Val Leu 
        195                 200                 205             


Cys Thr Cys Asn Val Thr Lys Gln Glu Cys Lys Lys Ile His Cys Pro 
    210                 215                 220                 


Asn Arg Tyr Pro Cys Lys Tyr Pro Gln Lys Ile Asp Gly Lys Cys Cys 
225                 230                 235                 240 


Lys Val Cys Pro Gly Lys Lys Ala Lys Glu Glu Leu Pro Gly Gln Ser 
                245                 250                 255     


Phe Asp Asn Lys Gly Tyr Phe Cys Gly Glu Glu Thr Met Pro Val Tyr 
            260                 265                 270         


Glu Ser Val Phe Met Glu Asp Gly Glu Thr Thr Arg Lys Ile Ala Leu 
        275                 280                 285             


Glu Thr Glu Arg Pro Pro Gln Val Glu Val His Val Trp Thr Ile Arg 
    290                 295                 300                 


Lys Gly Ile Leu Gln His Phe His Ile Glu Lys Ile Ser Lys Arg Met 
305                 310                 315                 320 


Phe Glu Glu Leu Pro His Phe Lys Leu Val Thr Arg Thr Thr Leu Ser 
                325                 330                 335     


Gln Trp Lys Ile Phe Thr Glu Gly Glu Ala Gln Ile Ser Gln Met Cys 
            340                 345                 350         


Ser Ser Arg Val Cys Arg Thr Glu Leu Glu Asp Leu Val Lys Val Leu 
        355                 360                 365             


Tyr Leu Glu Arg Ser Glu Lys Gly His Cys 
    370                 375             


<210>  2854
<211>  142
<212>  PRT
<213>  Homo Sapiens

<400>  2854

Met Ala Leu Val Gly Leu Pro Gly Pro Asp Met Phe Cys Leu Phe His 
1               5                   10                  15      


Gly Lys Arg Tyr Ser Pro Gly Glu Ser Trp His Pro Tyr Leu Glu Pro 
            20                  25                  30          


Gln Gly Leu Met Tyr Cys Leu Arg Cys Thr Cys Ser Glu Gly Ala His 
        35                  40                  45              


Val Ser Cys Tyr Arg Leu His Cys Pro Pro Val His Cys Pro Gln Pro 
    50                  55                  60                  


Val Thr Glu Pro Gln Gln Cys Cys Pro Lys Cys Val Glu Pro His Thr 
65                  70                  75                  80  


Pro Ser Gly Leu Arg Ala Pro Pro Lys Ser Cys Gln His Asn Gly Thr 
                85                  90                  95      


Met Tyr Gln His Gly Glu Ile Phe Ser Ala His Glu Leu Phe Pro Ser 
            100                 105                 110         


Arg Leu Pro Asn Gln Cys Val Leu Cys Ser Cys Thr Met Arg Gln Val 
        115                 120                 125             


Ser Asn Arg Met Lys Arg Thr Val Cys Ser Arg Ser Met Gly 
    130                 135                 140         


<210>  2855
<211>  93
<212>  PRT
<213>  Homo Sapiens

<400>  2855

Met Ala Leu Val Gly Leu Pro Gly Pro Asp Met Phe Cys Leu Phe His 
1               5                   10                  15      


Gly Lys Arg Tyr Ser Pro Gly Glu Ser Trp His Pro Tyr Leu Glu Pro 
            20                  25                  30          


Gln Gly Leu Met Tyr Cys Leu Arg Cys Thr Cys Ser Glu Asn Leu Thr 
        35                  40                  45              


Leu Pro Leu Asp Ser Gly Pro His Gln Ser Pro Ala Ser Thr Thr Gly 
    50                  55                  60                  


Pro Cys Thr Asn Thr Glu Arg Ser Ser Val Pro Met Ser Cys Ser Pro 
65                  70                  75                  80  


Pro Ala Cys Pro Thr Ser Val Ser Ser Ala Ala Ala Gln 
                85                  90              


<210>  2856
<211>  142
<212>  PRT
<213>  Homo Sapiens

<400>  2856

Met Ala Leu Val Gly Leu Pro Gly Pro Asp Met Phe Cys Leu Phe His 
1               5                   10                  15      


Gly Lys Arg Tyr Ser Pro Gly Glu Ser Trp His Pro Tyr Leu Glu Pro 
            20                  25                  30          


Gln Gly Leu Met Tyr Cys Leu Arg Cys Thr Cys Ser Glu Asn Leu Thr 
        35                  40                  45              


Leu Pro Leu Asp Ser Gly Pro His Gln Ser Pro Ala Ser Thr Thr Gly 
    50                  55                  60                  


Pro Cys Thr Asn Thr Glu Arg Ser Ser Val Pro Met Ser Cys Ser Pro 
65                  70                  75                  80  


Pro Ala Cys Pro Thr Ser Val Ser Ser Ala Ala Ala Gln Arg Ala Arg 
                85                  90                  95      


Ser Thr Ala Ala Ser Gln Pro Ala Pro Asn Gln Ala Ala Gln His Pro 
            100                 105                 110         


Ser Arg Cys Gln Thr Pro Ala Ala Arg Pro Ala Lys Met Arg Gln Val 
        115                 120                 125             


Ser Asn Arg Met Lys Arg Thr Val Cys Ser Arg Ser Met Gly 
    130                 135                 140         


<210>  2857
<211>  451
<212>  PRT
<213>  Homo Sapiens

<400>  2857

Met Val Pro Glu Val Arg Val Leu Ser Ser Leu Leu Gly Leu Ala Leu 
1               5                   10                  15      


Leu Trp Phe Pro Leu Asp Ser His Ala Arg Ala Arg Pro Asp Met Phe 
            20                  25                  30          


Cys Leu Phe His Gly Lys Arg Tyr Ser Pro Gly Glu Ser Trp His Pro 
        35                  40                  45              


Tyr Leu Glu Pro Gln Gly Leu Met Tyr Cys Leu Arg Cys Thr Cys Ser 
    50                  55                  60                  


Glu Gly Ala His Val Ser Cys Tyr Arg Leu His Cys Pro Pro Val His 
65                  70                  75                  80  


Cys Pro Gln Pro Val Thr Glu Pro Gln Gln Cys Cys Pro Lys Cys Val 
                85                  90                  95      


Glu Pro His Thr Pro Ser Gly Leu Arg Ala Pro Pro Lys Ser Cys Gln 
            100                 105                 110         


His Asn Gly Thr Met Tyr Gln His Gly Glu Ile Phe Ser Ala His Glu 
        115                 120                 125             


Leu Phe Pro Ser Arg Leu Pro Asn Gln Cys Val Leu Cys Ser Cys Thr 
    130                 135                 140                 


Glu Gly Gln Ile Tyr Cys Gly Leu Thr Thr Cys Pro Glu Pro Gly Cys 
145                 150                 155                 160 


Pro Ala Pro Leu Pro Leu Pro Asp Ser Cys Cys Gln Ala Cys Lys Asp 
                165                 170                 175     


Glu Ala Ser Glu Gln Ser Asp Glu Glu Asp Ser Val Gln Ser Leu His 
            180                 185                 190         


Gly Val Arg His Pro Gln Asp Pro Cys Ser Ser Asp Ala Gly Arg Lys 
        195                 200                 205             


Arg Gly Pro Gly Thr Pro Ala Pro Thr Gly Leu Ser Ala Pro Leu Ser 
    210                 215                 220                 


Phe Ile Pro Arg His Phe Arg Pro Lys Gly Ala Gly Ser Thr Thr Val 
225                 230                 235                 240 


Lys Ile Val Leu Lys Glu Lys His Lys Lys Ala Cys Val His Gly Gly 
                245                 250                 255     


Lys Thr Tyr Ser His Gly Glu Val Trp His Pro Ala Phe Arg Ala Phe 
            260                 265                 270         


Gly Pro Leu Pro Cys Ile Leu Cys Thr Cys Glu Asp Gly Arg Gln Asp 
        275                 280                 285             


Cys Gln Arg Val Thr Cys Pro Thr Glu Tyr Pro Cys Arg His Pro Glu 
    290                 295                 300                 


Lys Val Ala Gly Lys Cys Cys Lys Ile Cys Pro Glu Asp Lys Ala Asp 
305                 310                 315                 320 


Pro Gly His Ser Glu Ile Ser Ser Thr Arg Cys Pro Lys Ala Pro Gly 
                325                 330                 335     


Arg Val Leu Val His Thr Ser Val Ser Pro Ser Pro Asp Asn Leu Arg 
            340                 345                 350         


Arg Phe Ala Leu Glu His Glu Ala Ser Asp Leu Val Glu Ile Tyr Leu 
        355                 360                 365             


Trp Lys Leu Val Lys Asp Glu Glu Thr Glu Ala Gln Arg Gly Glu Val 
    370                 375                 380                 


Pro Gly Pro Arg Pro His Ser Gln Asn Leu Pro Leu Asp Ser Asp Gln 
385                 390                 395                 400 


Glu Ser Gln Glu Ala Arg Leu Pro Glu Arg Gly Thr Ala Leu Pro Thr 
                405                 410                 415     


Ala Arg Trp Pro Pro Arg Arg Ser Leu Glu Arg Leu Pro Ser Pro Asp 
            420                 425                 430         


Pro Gly Ala Glu Gly His Gly Gln Ser Arg Gln Ser Asp Gln Asp Ile 
        435                 440                 445             


Thr Lys Thr 
    450     


<210>  2858
<211>  429
<212>  PRT
<213>  Homo Sapiens

<400>  2858

Met Val Pro Glu Val Arg Val Leu Ser Ser Leu Leu Gly Leu Ala Leu 
1               5                   10                  15      


Leu Trp Phe Pro Leu Asp Ser His Ala Arg Ala Arg Pro Asp Met Phe 
            20                  25                  30          


Cys Leu Phe His Gly Lys Arg Tyr Ser Pro Gly Glu Ser Trp His Pro 
        35                  40                  45              


Tyr Leu Glu Pro Gln Gly Leu Met Tyr Cys Leu Arg Cys Thr Cys Ser 
    50                  55                  60                  


Glu Gly Ala His Val Ser Cys Tyr Arg Leu His Cys Pro Pro Val His 
65                  70                  75                  80  


Cys Pro Gln Pro Val Thr Glu Pro Gln Gln Cys Cys Pro Lys Cys Val 
                85                  90                  95      


Glu Pro His Thr Pro Ser Gly Leu Arg Ala Pro Pro Lys Ser Cys Gln 
            100                 105                 110         


His Asn Gly Thr Met Tyr Gln His Gly Glu Ile Phe Ser Ala His Glu 
        115                 120                 125             


Leu Phe Pro Ser Arg Leu Pro Asn Gln Cys Val Leu Cys Ser Cys Thr 
    130                 135                 140                 


Glu Gly Gln Ile Tyr Cys Gly Leu Thr Thr Cys Pro Glu Pro Gly Cys 
145                 150                 155                 160 


Pro Ala Pro Leu Pro Leu Pro Asp Ser Cys Cys Gln Ala Cys Lys Asp 
                165                 170                 175     


Glu Ala Ser Glu Gln Ser Asp Glu Glu Asp Ser Val Gln Ser Leu His 
            180                 185                 190         


Gly Val Arg His Pro Gln Asp Pro Cys Ser Ser Asp Ala Gly Arg Lys 
        195                 200                 205             


Arg Gly Pro Gly Thr Pro Ala Pro Thr Gly Leu Ser Ala Pro Leu Ser 
    210                 215                 220                 


Phe Ile Pro Arg His Phe Arg Pro Lys Gly Ala Gly Ser Thr Thr Val 
225                 230                 235                 240 


Lys Ile Val Leu Lys Glu Lys His Lys Lys Ala Cys Val His Gly Gly 
                245                 250                 255     


Lys Thr Tyr Ser His Gly Glu Val Trp His Pro Ala Phe Arg Ala Phe 
            260                 265                 270         


Gly Pro Leu Pro Cys Ile Leu Cys Thr Cys Glu Asp Gly Arg Gln Asp 
        275                 280                 285             


Cys Gln Arg Val Thr Cys Pro Thr Glu Tyr Pro Cys Arg His Pro Glu 
    290                 295                 300                 


Lys Val Ala Gly Lys Cys Cys Lys Ile Cys Pro Glu Asp Lys Ala Asp 
305                 310                 315                 320 


Pro Gly His Ser Glu Ile Ser Ser Thr Arg Cys Pro Lys Ala Pro Gly 
                325                 330                 335     


Arg Val Leu Val His Thr Ser Val Ser Pro Ser Pro Asp Asn Leu Arg 
            340                 345                 350         


Arg Phe Ala Leu Glu His Glu Ala Ser Asp Leu Val Glu Ile Tyr Leu 
        355                 360                 365             


Trp Lys Leu Val Lys Gly Ile Phe His Leu Thr Gln Ile Lys Lys Val 
    370                 375                 380                 


Arg Lys Gln Asp Phe Gln Lys Glu Ala Gln His Phe Arg Leu Leu Ala 
385                 390                 395                 400 


Gly Pro His Glu Gly His Trp Asn Val Phe Leu Ala Gln Thr Leu Glu 
                405                 410                 415     


Leu Lys Val Thr Ala Ser Pro Asp Lys Val Thr Lys Thr 
            420                 425                 


<210>  2859
<211>  308
<212>  PRT
<213>  Homo Sapiens

<400>  2859

Met Val Pro Glu Val Arg Val Leu Ser Ser Leu Leu Gly Leu Ala Leu 
1               5                   10                  15      


Leu Trp Phe Pro Leu Asp Ser His Ala Arg Ala Arg Pro Asp Met Phe 
            20                  25                  30          


Cys Leu Phe His Gly Lys Arg Tyr Ser Pro Gly Glu Ser Trp His Pro 
        35                  40                  45              


Tyr Leu Glu Pro Gln Gly Leu Met Tyr Cys Leu Arg Cys Thr Cys Ser 
    50                  55                  60                  


Glu Gly Ala His Val Ser Cys Tyr Arg Leu His Cys Pro Pro Val His 
65                  70                  75                  80  


Cys Pro Gln Pro Val Thr Glu Pro Gln Gln Cys Cys Pro Lys Cys Val 
                85                  90                  95      


Glu Pro His Thr Pro Ser Gly Leu Arg Ala Pro Pro Lys Ser Cys Gln 
            100                 105                 110         


His Asn Gly Thr Met Tyr Gln His Gly Glu Ile Phe Ser Ala His Glu 
        115                 120                 125             


Leu Phe Pro Ser Arg Leu Pro Asn Gln Cys Val Leu Cys Ser Cys Thr 
    130                 135                 140                 


Glu Gly Gln Ile Tyr Cys Gly Leu Thr Thr Cys Pro Glu Pro Gly Cys 
145                 150                 155                 160 


Pro Ala Pro Leu Pro Leu Pro Asp Ser Cys Cys Gln Ala Cys Lys Asp 
                165                 170                 175     


Glu Ala Ser Glu Gln Ser Asp Glu Glu Asp Ser Val Gln Ser Leu His 
            180                 185                 190         


Gly Val Arg His Pro Gln Asp Pro Cys Ser Ser Asp Ala Gly Arg Lys 
        195                 200                 205             


Arg Gly Pro Gly Thr Pro Ala Pro Thr Gly Leu Ser Ala Pro Leu Ser 
    210                 215                 220                 


Phe Ile Pro Arg His Phe Arg Pro Lys Gly Ala Gly Ser Thr Thr Val 
225                 230                 235                 240 


Lys Ile Val Leu Lys Glu Lys His Lys Lys Glu Asp Lys Ala Asp Pro 
                245                 250                 255     


Gly His Ser Glu Ile Ser Ser Thr Arg Cys Pro Lys Ala Pro Gly Arg 
            260                 265                 270         


Val Leu Val His Thr Ser Val Ser Pro Ser Pro Asp Asn Leu Arg Arg 
        275                 280                 285             


Phe Ala Leu Glu His Glu Ala Ser Asp Leu Val Glu Ile Tyr Leu Trp 
    290                 295                 300                 


Lys Leu Val Lys 
305             


<210>  2860
<211>  281
<212>  PRT
<213>  Homo Sapiens

<400>  2860

Met Tyr Gln His Gly Glu Ile Phe Ser Ala His Glu Leu Phe Pro Ser 
1               5                   10                  15      


Arg Leu Pro Asn Gln Cys Val Leu Cys Ser Cys Thr Glu Gly Gln Ile 
            20                  25                  30          


Tyr Cys Gly Leu Thr Thr Cys Pro Glu Pro Gly Cys Pro Ala Pro Leu 
        35                  40                  45              


Pro Leu Pro Asp Ser Cys Cys Gln Ala Cys Lys Ala Gly Ser Ser Trp 
    50                  55                  60                  


Gly Leu Leu Cys Ser Val Ser Asp Phe His Pro Ser Cys His Leu Gln 
65                  70                  75                  80  


Arg His Pro Gln Asp Pro Cys Ser Ser Asp Ala Gly Arg Lys Arg Gly 
                85                  90                  95      


Pro Gly Thr Pro Ala Pro Thr Gly Leu Ser Ala Pro Leu Ser Phe Ile 
            100                 105                 110         


Pro Arg His Phe Arg Pro Lys Gly Ala Gly Ser Thr Thr Val Lys Ile 
        115                 120                 125             


Val Leu Lys Glu Lys His Lys Lys Ala Cys Val His Gly Gly Lys Thr 
    130                 135                 140                 


Tyr Ser His Gly Glu Val Trp His Pro Ala Phe Arg Ala Phe Gly Pro 
145                 150                 155                 160 


Leu Pro Cys Ile Leu Cys Thr Cys Glu Asp Gly Arg Gln Asp Cys Gln 
                165                 170                 175     


Arg Val Thr Cys Pro Thr Glu Tyr Pro Cys Arg His Pro Glu Lys Val 
            180                 185                 190         


Ala Gly Lys Cys Cys Lys Ile Cys Pro Glu Asp Lys Ala Asp Pro Gly 
        195                 200                 205             


His Ser Glu Ile Ser Ser Thr Arg Cys Pro Lys Ala Pro Gly Arg Val 
    210                 215                 220                 


Leu Val His Thr Ser Val Ser Pro Ser Pro Asp Asn Leu Arg Arg Phe 
225                 230                 235                 240 


Ala Leu Glu His Glu Ala Ser Asp Leu Val Glu Ile Tyr Leu Trp Lys 
                245                 250                 255     


Leu Val Lys Asp Val Phe Leu Ala Gln Thr Leu Glu Leu Lys Val Thr 
            260                 265                 270         


Ala Ser Pro Asp Lys Val Thr Lys Thr 
        275                 280     


<210>  2861
<211>  91
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2861

Xaa Gly Asp Arg Ser Arg Ile Ser Lys Glu Asn Arg Gln Lys Lys Thr 
1               5                   10                  15      


Gly Phe Thr Val Glu Ala Thr Gly Arg Gln Gly Arg Gly Met Thr Gly 
            20                  25                  30          


Asn Leu Pro Leu Asp Ser Asp Gln Glu Ser Gln Glu Ala Arg Leu Pro 
        35                  40                  45              


Glu Arg Gly Thr Ala Leu Pro Thr Ala Arg Trp Pro Pro Arg Arg Ser 
    50                  55                  60                  


Leu Glu Arg Leu Pro Ser Pro Asp Pro Gly Ala Glu Gly His Gly Gln 
65                  70                  75                  80  


Ser Arg Gln Ser Asp Gln Asp Ile Thr Lys Thr 
                85                  90      


<210>  2862
<211>  177
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2862

Xaa Ser Ser Asp Ala Gly Arg Lys Arg Gly Pro Gly Thr Pro Ala Pro 
1               5                   10                  15      


Thr Gly Leu Ser Ala Pro Leu Ser Phe Ile Pro Arg His Phe Arg Pro 
            20                  25                  30          


Lys Gly Ala Gly Ser Thr Thr Val Lys Ile Val Leu Lys Glu Lys His 
        35                  40                  45              


Lys Lys Ala Cys Val His Gly Gly Lys Thr Tyr Ser His Gly Glu Val 
    50                  55                  60                  


Trp His Pro Ala Phe Arg Ala Phe Gly Pro Leu Pro Cys Ile Leu Cys 
65                  70                  75                  80  


Thr Cys Glu Asp Gly Arg Gln Asp Cys Gln Arg Val Thr Cys Pro Thr 
                85                  90                  95      


Glu Tyr Pro Cys Arg His Pro Glu Lys Val Ala Gly Lys Cys Cys Lys 
            100                 105                 110         


Ile Cys Pro Glu Asp Lys Ala Asp Pro Gly His Ser Glu Ile Ser Ser 
        115                 120                 125             


Thr Arg Cys Pro Lys Ala Pro Gly Arg Val Leu Val His Thr Ser Val 
    130                 135                 140                 


Ser Pro Ser Pro Asp Asn Leu Arg Arg Phe Ala Leu Glu His Glu Ala 
145                 150                 155                 160 


Ser Asp Leu Val Glu Ile Tyr Leu Trp Lys Leu Val Thr Gly Thr Ser 
                165                 170                 175     


Ser 
    


<210>  2863
<211>  507
<212>  PRT
<213>  Homo Sapiens

<400>  2863

Met Ala Gly Gly Glu Glu Ala Lys Arg Pro Pro Pro Arg Ala Pro Gly 
1               5                   10                  15      


Asp Pro Leu Ser Ser Pro Ser Pro Thr Ala Leu Pro Gln Gly Gly Ser 
            20                  25                  30          


His Thr Glu Thr Glu Asp Arg Leu Phe Lys His Leu Phe Arg Gly Tyr 
        35                  40                  45              


Asn Arg Trp Ala Arg Pro Val Pro Asn Thr Ser Asp Val Val Ile Val 
    50                  55                  60                  


Arg Phe Gly Leu Ser Ile Ala Gln Leu Ile Asp Val Asp Glu Lys Asn 
65                  70                  75                  80  


Gln Met Met Thr Thr Asn Val Trp Leu Lys Gln Glu Trp Ser Asp Tyr 
                85                  90                  95      


Lys Leu Arg Trp Asn Pro Thr Asp Phe Gly Asn Ile Thr Ser Leu Arg 
            100                 105                 110         


Val Pro Ser Glu Met Ile Trp Ile Pro Asp Ile Val Leu Tyr Asn Asn 
        115                 120                 125             


Ala Asp Gly Glu Phe Ala Val Thr His Met Thr Lys Ala His Leu Phe 
    130                 135                 140                 


Ser Thr Gly Thr Val His Trp Val Pro Pro Ala Ile Tyr Lys Ser Ser 
145                 150                 155                 160 


Cys Ser Ile Asp Val Thr Phe Phe Pro Phe Asp Gln Gln Asn Cys Lys 
                165                 170                 175     


Met Lys Phe Gly Ser Trp Thr Tyr Asp Lys Ala Lys Ile Asp Leu Glu 
            180                 185                 190         


Gln Met Glu Gln Thr Val Asp Leu Lys Asp Tyr Trp Glu Ser Gly Glu 
        195                 200                 205             


Trp Ala Ile Val Asn Ala Thr Gly Thr Tyr Asn Ser Lys Lys Tyr Asp 
    210                 215                 220                 


Cys Cys Ala Glu Ile Tyr Pro Asp Val Thr Tyr Ala Phe Val Ile Arg 
225                 230                 235                 240 


Arg Leu Pro Leu Phe Tyr Thr Ile Asn Leu Ile Ile Pro Cys Leu Leu 
                245                 250                 255     


Ile Ser Cys Leu Thr Val Leu Val Phe Tyr Leu Pro Ser Asp Cys Gly 
            260                 265                 270         


Glu Lys Ile Thr Leu Cys Ile Ser Val Leu Leu Ser Leu Thr Val Phe 
        275                 280                 285             


Leu Leu Leu Ile Thr Glu Ile Ile Pro Ser Thr Ser Leu Val Ile Pro 
    290                 295                 300                 


Leu Ile Gly Glu Tyr Leu Leu Phe Thr Met Ile Phe Val Thr Leu Ser 
305                 310                 315                 320 


Ile Val Ile Thr Val Phe Val Leu Asn Val His His Arg Ser Pro Ser 
                325                 330                 335     


Thr His Thr Met Pro His Trp Val Arg Gly Ala Leu Leu Gly Cys Val 
            340                 345                 350         


Pro Arg Trp Leu Leu Met Asn Arg Pro Pro Pro Pro Val Glu Leu Cys 
        355                 360                 365             


His Pro Leu Arg Leu Lys Leu Ser Pro Ser Tyr His Trp Leu Glu Ser 
    370                 375                 380                 


Asn Val Asp Ala Glu Glu Arg Glu Val Val Val Glu Glu Glu Asp Arg 
385                 390                 395                 400 


Trp Ala Cys Ala Gly His Val Ala Pro Ser Val Gly Thr Leu Cys Ser 
                405                 410                 415     


His Gly His Leu His Ser Gly Ala Ser Gly Pro Lys Ala Glu Ala Leu 
            420                 425                 430         


Leu Gln Glu Gly Glu Leu Leu Leu Ser Pro His Met Gln Lys Ala Leu 
        435                 440                 445             


Glu Gly Val His Tyr Ile Ala Asp His Leu Arg Ser Glu Asp Ala Asp 
    450                 455                 460                 


Ser Ser Val Lys Glu Asp Trp Lys Tyr Val Ala Met Val Ile Asp Arg 
465                 470                 475                 480 


Ile Phe Leu Trp Leu Phe Ile Ile Val Cys Phe Leu Gly Thr Ile Gly 
                485                 490                 495     


Leu Phe Leu Pro Pro Phe Leu Ala Gly Met Ile 
            500                 505         


<210>  2864
<211>  19
<212>  PRT
<213>  Homo Sapiens

<400>  2864

Met Gly Pro Ser Cys Pro Val Phe Leu Ser Phe Thr Lys Leu Ser Leu 
1               5                   10                  15      


Trp Trp Leu 
            


<210>  2865
<211>  50
<212>  PRT
<213>  Homo Sapiens

<400>  2865

Met Gly Pro Ser Cys Pro Val Phe Leu Ser Phe Thr Lys Leu Ser Leu 
1               5                   10                  15      


Trp Trp Leu Leu Leu Thr Pro Ala Gly Gly Glu Glu Ala Lys Arg Pro 
            20                  25                  30          


Pro Pro Arg Ala Pro Gly Asp Pro Leu Ser Ser Pro Ser Pro Thr Ala 
        35                  40                  45              


Leu Pro 
    50  


<210>  2866
<211>  81
<212>  PRT
<213>  Homo Sapiens

<400>  2866

Met Gly Pro Ser Cys Pro Val Phe Leu Ser Phe Thr Lys Leu Ser Leu 
1               5                   10                  15      


Trp Trp Leu Leu Leu Thr Pro Ala Gly Gly Glu Glu Ala Lys Arg Pro 
            20                  25                  30          


Pro Pro Arg Ala Pro Gly Asp Pro Leu Ser Ser Pro Ser Pro Thr Ala 
        35                  40                  45              


Leu Pro Gln Gly Gly Ser His Thr Glu Thr Glu Asp Arg Leu Phe Lys 
    50                  55                  60                  


His Leu Phe Arg Gly Tyr Asn Arg Trp Ala Arg Pro Val Pro Asn Thr 
65                  70                  75                  80  


Ser 
    


<210>  2867
<211>  514
<212>  PRT
<213>  Homo Sapiens

<400>  2867

Met Gly Pro Ser Cys Pro Val Phe Leu Ser Phe Thr Lys Leu Ser Leu 
1               5                   10                  15      


Trp Trp Leu Leu Leu Thr Pro Ala Gly Gly Glu Glu Ala Lys Arg Pro 
            20                  25                  30          


Pro Pro Arg Ala Pro Gly Asp Pro Leu Ser Ser Pro Ser Pro Thr Ala 
        35                  40                  45              


Leu Pro Gln Gly Gly Ser His Thr Glu Thr Glu Asp Arg Leu Phe Lys 
    50                  55                  60                  


His Leu Phe Arg Gly Tyr Asn Arg Trp Ala Arg Pro Val Pro Asn Thr 
65                  70                  75                  80  


Ser Asp Val Asp Glu Lys Asn Gln Met Met Thr Thr Asn Val Trp Leu 
                85                  90                  95      


Lys Gln Glu Trp Ser Asp Tyr Lys Leu Arg Trp Asn Pro Thr Asp Phe 
            100                 105                 110         


Gly Asn Ile Thr Ser Leu Arg Val Pro Ser Glu Met Ile Trp Ile Pro 
        115                 120                 125             


Asp Ile Val Leu Tyr Asn Asn Ala Asp Gly Glu Phe Ala Val Thr His 
    130                 135                 140                 


Met Thr Lys Ala His Leu Phe Ser Thr Gly Thr Val His Trp Val Pro 
145                 150                 155                 160 


Pro Ala Ile Tyr Lys Ser Ser Cys Ser Ile Asp Val Thr Phe Phe Pro 
                165                 170                 175     


Phe Asp Gln Gln Asn Cys Lys Met Lys Phe Gly Ser Trp Thr Tyr Asp 
            180                 185                 190         


Lys Ala Lys Ile Asp Leu Glu Gln Met Glu Gln Thr Val Asp Leu Lys 
        195                 200                 205             


Asp Tyr Trp Glu Ser Gly Glu Trp Ala Ile Val Asn Ala Thr Gly Thr 
    210                 215                 220                 


Tyr Asn Ser Lys Lys Tyr Asp Cys Cys Ala Glu Ile Tyr Pro Asp Val 
225                 230                 235                 240 


Thr Tyr Ala Phe Val Ile Arg Arg Leu Pro Leu Phe Tyr Thr Ile Asn 
                245                 250                 255     


Leu Ile Ile Pro Cys Leu Leu Ile Ser Cys Leu Thr Val Leu Val Phe 
            260                 265                 270         


Tyr Leu Pro Ser Asp Cys Gly Glu Lys Ile Thr Leu Cys Ile Ser Val 
        275                 280                 285             


Leu Leu Ser Leu Thr Val Phe Leu Leu Leu Ile Thr Glu Ile Ile Pro 
    290                 295                 300                 


Ser Thr Ser Leu Val Ile Pro Leu Ile Gly Glu Tyr Leu Leu Phe Thr 
305                 310                 315                 320 


Met Ile Phe Val Thr Leu Ser Ile Val Ile Thr Val Phe Val Leu Asn 
                325                 330                 335     


Val His His Arg Ser Pro Ser Thr His Thr Met Pro His Trp Val Arg 
            340                 345                 350         


Gly Ala Leu Leu Gly Cys Val Pro Arg Trp Leu Leu Met Asn Arg Pro 
        355                 360                 365             


Pro Pro Pro Val Glu Leu Cys His Pro Leu Arg Leu Lys Leu Ser Pro 
    370                 375                 380                 


Ser Tyr His Trp Leu Glu Ser Asn Val Asp Ala Glu Glu Arg Glu Val 
385                 390                 395                 400 


Val Val Glu Glu Glu Asp Arg Trp Ala Cys Ala Gly His Val Ala Pro 
                405                 410                 415     


Ser Val Gly Thr Leu Cys Ser His Gly His Leu His Ser Gly Ala Ser 
            420                 425                 430         


Gly Pro Lys Ala Glu Ala Leu Leu Gln Glu Gly Glu Leu Leu Leu Ser 
        435                 440                 445             


Pro His Met Gln Lys Ala Leu Glu Gly Val His Tyr Ile Ala Asp His 
    450                 455                 460                 


Leu Arg Ser Glu Asp Ala Asp Ser Ser Val Lys Glu Asp Trp Lys Tyr 
465                 470                 475                 480 


Val Ala Met Val Ile Asp Arg Ile Phe Leu Trp Leu Phe Ile Ile Val 
                485                 490                 495     


Cys Phe Leu Gly Thr Ile Gly Leu Phe Leu Pro Pro Phe Leu Ala Gly 
            500                 505                 510         


Met Ile 
        


<210>  2868
<211>  108
<212>  PRT
<213>  Homo Sapiens

<400>  2868

Met Gly Pro Ser Cys Pro Val Phe Leu Ser Phe Thr Lys Leu Ser Leu 
1               5                   10                  15      


Trp Trp Leu Leu Leu Thr Pro Ala Gly Gly Glu Glu Ala Lys Arg Pro 
            20                  25                  30          


Pro Pro Arg Ala Pro Gly Asp Pro Leu Ser Ser Pro Ser Pro Thr Ala 
        35                  40                  45              


Leu Pro Gln Gly Gly Ser His Thr Glu Thr Glu Asp Arg Leu Phe Lys 
    50                  55                  60                  


His Leu Phe Arg Gly Tyr Asn Arg Trp Ala Arg Pro Val Pro Asn Thr 
65                  70                  75                  80  


Ser Asp Val Val Ile Val Arg Phe Gly Leu Ser Ile Ala Gln Leu Ile 
                85                  90                  95      


Asp Val Asp Glu Lys Asn Gln Met Met Thr Thr Asn 
            100                 105             


<210>  2869
<211>  529
<212>  PRT
<213>  Homo Sapiens

<400>  2869

Met Gly Pro Ser Cys Pro Val Phe Leu Ser Phe Thr Lys Leu Ser Leu 
1               5                   10                  15      


Trp Trp Leu Leu Leu Thr Pro Ala Gly Gly Glu Glu Ala Lys Arg Pro 
            20                  25                  30          


Pro Pro Arg Ala Pro Gly Asp Pro Leu Ser Ser Pro Ser Pro Thr Ala 
        35                  40                  45              


Leu Pro Gln Gly Gly Ser His Thr Glu Thr Glu Asp Arg Leu Phe Lys 
    50                  55                  60                  


His Leu Phe Arg Gly Tyr Asn Arg Trp Ala Arg Pro Val Pro Asn Thr 
65                  70                  75                  80  


Ser Asp Val Val Ile Val Arg Phe Gly Leu Ser Ile Ala Gln Leu Ile 
                85                  90                  95      


Asp Val Asp Glu Lys Asn Gln Met Met Thr Thr Asn Val Trp Leu Lys 
            100                 105                 110         


Gln Glu Trp Ser Asp Tyr Lys Leu Arg Trp Asn Pro Thr Asp Phe Gly 
        115                 120                 125             


Asn Ile Thr Ser Leu Arg Val Pro Ser Glu Met Ile Trp Ile Pro Asp 
    130                 135                 140                 


Ile Val Leu Tyr Asn Asn Ala Asp Gly Glu Phe Ala Val Thr His Met 
145                 150                 155                 160 


Thr Lys Ala His Leu Phe Ser Thr Gly Thr Val His Trp Val Pro Pro 
                165                 170                 175     


Ala Ile Tyr Lys Ser Ser Cys Ser Ile Asp Val Thr Phe Phe Pro Phe 
            180                 185                 190         


Asp Gln Gln Asn Cys Lys Met Lys Phe Gly Ser Trp Thr Tyr Asp Lys 
        195                 200                 205             


Ala Lys Ile Asp Leu Glu Gln Met Glu Gln Thr Val Asp Leu Lys Asp 
    210                 215                 220                 


Tyr Trp Glu Ser Gly Glu Trp Ala Ile Val Asn Ala Thr Gly Thr Tyr 
225                 230                 235                 240 


Asn Ser Lys Lys Tyr Asp Cys Cys Ala Glu Ile Tyr Pro Asp Val Thr 
                245                 250                 255     


Tyr Ala Phe Val Ile Arg Arg Leu Pro Leu Phe Tyr Thr Ile Asn Leu 
            260                 265                 270         


Ile Ile Pro Cys Leu Leu Ile Ser Cys Leu Thr Val Leu Val Phe Tyr 
        275                 280                 285             


Leu Pro Ser Asp Cys Gly Glu Lys Ile Thr Leu Cys Ile Ser Val Leu 
    290                 295                 300                 


Leu Ser Leu Thr Val Phe Leu Leu Leu Ile Thr Glu Ile Ile Pro Ser 
305                 310                 315                 320 


Thr Ser Leu Val Ile Pro Leu Ile Gly Glu Tyr Leu Leu Phe Thr Met 
                325                 330                 335     


Ile Phe Val Thr Leu Ser Ile Val Ile Thr Val Phe Val Leu Asn Val 
            340                 345                 350         


His His Arg Ser Pro Ser Thr His Thr Met Pro His Trp Val Arg Gly 
        355                 360                 365             


Ala Leu Leu Gly Cys Val Pro Arg Trp Leu Leu Met Asn Arg Pro Pro 
    370                 375                 380                 


Pro Pro Val Glu Leu Cys His Pro Leu Arg Leu Lys Leu Ser Pro Ser 
385                 390                 395                 400 


Tyr His Trp Leu Glu Ser Asn Val Asp Ala Glu Glu Arg Glu Val Val 
                405                 410                 415     


Val Glu Glu Glu Asp Arg Trp Ala Cys Ala Gly His Val Ala Pro Ser 
            420                 425                 430         


Val Gly Thr Leu Cys Ser His Gly His Leu His Ser Gly Ala Ser Gly 
        435                 440                 445             


Pro Lys Ala Glu Ala Leu Leu Gln Glu Gly Glu Leu Leu Leu Ser Pro 
    450                 455                 460                 


His Met Gln Lys Ala Leu Glu Gly Val His Tyr Ile Ala Asp His Leu 
465                 470                 475                 480 


Arg Ser Glu Asp Ala Asp Ser Ser Val Lys Glu Asp Trp Lys Tyr Val 
                485                 490                 495     


Ala Met Val Ile Asp Arg Ile Phe Leu Trp Leu Phe Ile Ile Val Cys 
            500                 505                 510         


Phe Leu Gly Thr Ile Gly Leu Phe Leu Pro Pro Phe Leu Ala Gly Met 
        515                 520                 525             


Ile 
    


<210>  2870
<211>  154
<212>  PRT
<213>  Homo Sapiens

<400>  2870

Met Gly Pro Ser Cys Pro Val Phe Leu Ser Phe Thr Lys Leu Ser Leu 
1               5                   10                  15      


Trp Trp Leu Leu Leu Thr Pro Ala Gly Gly Glu Glu Ala Lys Arg Pro 
            20                  25                  30          


Pro Pro Arg Ala Pro Gly Asp Pro Leu Ser Ser Pro Ser Pro Thr Ala 
        35                  40                  45              


Leu Pro Gln Gly Gly Ser His Thr Glu Thr Glu Asp Arg Leu Phe Lys 
    50                  55                  60                  


His Leu Phe Arg Gly Tyr Asn Arg Trp Ala Arg Pro Val Pro Asn Thr 
65                  70                  75                  80  


Ser Asp Val Val Ile Val Arg Phe Gly Leu Ser Ile Ala Gln Leu Ile 
                85                  90                  95      


Asp Val Asp Glu Lys Asn Gln Met Met Thr Thr Asn Val Trp Leu Lys 
            100                 105                 110         


Gln Glu Trp Ser Asp Tyr Lys Leu Arg Trp Asn Pro Thr Asp Phe Gly 
        115                 120                 125             


Asn Ile Thr Ser Leu Arg Val Pro Ser Glu Met Ile Trp Ile Pro Asp 
    130                 135                 140                 


Ile Val Leu Tyr Asn Asn Arg Thr Ala Arg 
145                 150                 


<210>  2871
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  2871

Met Gly Pro Ser Cys Pro Val Phe Leu Ser Phe Thr Lys Leu Ser Leu 
1               5                   10                  15      


Trp Trp Leu Leu Leu Thr Pro Ala Gly Gly Glu Glu Ala Lys Arg Pro 
            20                  25                  30          


Pro Pro Arg Ala Pro Gly Asp Pro Leu Ser Ser Pro Ser Pro Thr Ala 
        35                  40                  45              


Leu Pro Gln Gly Gly Ser His Thr Glu Thr Glu Asp Arg Leu Phe Lys 
    50                  55                  60                  


His Leu Phe Arg Gly Tyr Asn Arg Trp Ala Arg Pro Val Pro Asn Thr 
65                  70                  75                  80  


Ser Asp Val Val Ile Val Arg Phe Gly Leu Ser Ile Ala Gln Leu Ile 
                85                  90                  95      


Asp Val Val Arg Leu Ser Ser His Arg Trp Pro Glu Glu Gly Asp Pro 
            100                 105                 110         


Arg Pro Pro Thr Ala Phe Pro Leu Leu Leu Pro Leu Pro Gln Pro Cys 
        115                 120                 125             


Pro His Ala Gln Gln 
    130             


<210>  2872
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  2872

Met Ala Ala Arg Gly Ser Gly Pro Arg Ala Leu Arg Leu Leu Leu Leu 
1               5                   10                  15      


Val Gln Leu Val Ala Gly Arg Cys Gly Leu Ala Gly Ala Ala Gly Gly 
            20                  25                  30          


Ala Gln Arg Gly Leu Ser Glu Pro Ser Ser Ile Ala Lys His Glu Asp 
        35                  40                  45              


Ser Leu Leu Lys Asp Leu Phe Gln Asp Tyr Glu Arg Trp Val Arg Pro 
    50                  55                  60                  


Val Glu His Leu Asn Asp Lys Ile Lys Ile Lys Phe Gly Leu Ala Ile 
65                  70                  75                  80  


Ser Gln Leu Val Asp Val Asp Glu Lys Asn Gln Leu Met Thr Thr Asn 
                85                  90                  95      


Val Trp Leu Lys Gln Glu Trp Ile Asp Val Lys Leu Arg Trp Asn Pro 
            100                 105                 110         


Asp Asp Tyr Gly Gly Ile Lys Val Ile Arg Val Pro Ser Asp Ser Val 
        115                 120                 125             


Trp Thr Pro Asp Ile Val Leu Phe Asp Asn Ala Asp Gly Arg Phe Glu 
    130                 135                 140                 


Gly Thr Ser Thr Lys Thr Val Ile Arg Leu Leu Lys Ile Gly Asn Ser 
145                 150                 155                 160 


<210>  2873
<211>  468
<212>  PRT
<213>  Homo Sapiens

<400>  2873

Met Ala Ala Arg Gly Ser Gly Pro Arg Ala Leu Arg Leu Leu Leu Leu 
1               5                   10                  15      


Val Gln Leu Val Ala Gly Arg Cys Gly Leu Ala Gly Ala Ala Gly Gly 
            20                  25                  30          


Ala Gln Arg Gly Leu Ser Glu Pro Ser Ser Ile Ala Lys His Glu Asp 
        35                  40                  45              


Ser Leu Leu Lys Asp Leu Phe Gln Asp Tyr Glu Arg Trp Val Arg Pro 
    50                  55                  60                  


Val Glu His Leu Asn Asp Lys Ile Lys Ile Lys Phe Gly Leu Ala Ile 
65                  70                  75                  80  


Ser Gln Leu Val Asp Val Asp Glu Lys Asn Gln Leu Met Thr Thr Asn 
                85                  90                  95      


Val Trp Leu Lys Gln Glu Trp Ile Asp Val Lys Leu Arg Trp Asn Pro 
            100                 105                 110         


Asp Asp Tyr Gly Gly Ile Lys Val Ile Arg Val Pro Ser Asp Ser Val 
        115                 120                 125             


Trp Thr Pro Asp Ile Val Leu Phe Asp Asn Ala Asp Gly Arg Phe Glu 
    130                 135                 140                 


Gly Thr Ser Thr Lys Thr Val Ile Arg Tyr Asn Gly Thr Val Thr Trp 
145                 150                 155                 160 


Thr Pro Pro Ala Asn Tyr Lys Ser Ser Cys Thr Ile Asp Val Thr Phe 
                165                 170                 175     


Phe Pro Phe Asp Leu Gln Asn Cys Ser Met Lys Phe Gly Ser Trp Thr 
            180                 185                 190         


Tyr Asp Gly Ser Gln Val Asp Ile Ile Leu Glu Asp Gln Asp Val Asp 
        195                 200                 205             


Lys Arg Asp Phe Phe Asp Asn Gly Glu Trp Glu Ile Val Ser Ala Thr 
    210                 215                 220                 


Gly Ser Lys Gly Asn Arg Thr Asp Ser Cys Cys Trp Tyr Pro Tyr Val 
225                 230                 235                 240 


Thr Tyr Ser Phe Val Ile Lys Arg Leu Pro Leu Phe Tyr Thr Leu Phe 
                245                 250                 255     


Leu Ile Ile Pro Cys Ile Gly Leu Ser Phe Leu Thr Val Leu Val Phe 
            260                 265                 270         


Tyr Leu Pro Ser Asn Glu Gly Glu Lys Ile Cys Leu Cys Thr Ser Val 
        275                 280                 285             


Leu Val Ser Leu Thr Val Phe Leu Leu Val Ile Glu Glu Ile Ile Pro 
    290                 295                 300                 


Ser Ser Ser Lys Val Ile Pro Leu Ile Gly Glu Tyr Leu Val Phe Thr 
305                 310                 315                 320 


Met Ile Phe Val Thr Leu Ser Ile Met Val Thr Val Phe Ala Ile Asn 
                325                 330                 335     


Ile His His Arg Ser Ser Ser Thr His Asn Ala Met Ala Pro Leu Val 
            340                 345                 350         


Arg Lys Ile Phe Leu His Thr Leu Pro Lys Leu Leu Cys Met Arg Ser 
        355                 360                 365             


His Val Asp Arg Tyr Phe Thr Gln Lys Glu Glu Thr Glu Ser Gly Ser 
    370                 375                 380                 


Gly Pro Lys Ser Ser Arg Asn Thr Leu Glu Ala Ala Leu Asp Ser Ile 
385                 390                 395                 400 


Arg Tyr Ile Thr Arg His Ile Met Lys Glu Asn Asp Val Arg Glu Val 
                405                 410                 415     


Val Glu Asp Trp Lys Phe Ile Ala Gln Val Leu Asp Arg Met Phe Leu 
            420                 425                 430         


Trp Thr Phe Leu Phe Val Ser Ile Val Gly Ser Leu Gly Leu Phe Val 
        435                 440                 445             


Pro Val Ile Tyr Lys Trp Ala Asn Ile Leu Ile Pro Val His Ile Gly 
    450                 455                 460                 


Asn Ala Asn Lys 
465             


<210>  2874
<211>  182
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2874

Xaa Arg Pro Val Glu His Leu Asn Asp Lys Ile Lys Ile Lys Phe Gly 
1               5                   10                  15      


Leu Ala Ile Ser Gln Leu Val Asp Val Asp Glu Lys Asn Gln Leu Met 
            20                  25                  30          


Thr Thr Asn Val Trp Leu Lys Gln Glu Trp Ile Asp Val Lys Leu Arg 
        35                  40                  45              


Trp Asn Pro Asp Asp Tyr Gly Gly Ile Lys Val Ile Arg Val Pro Ser 
    50                  55                  60                  


Asp Ser Val Trp Thr Pro Asp Ile Val Leu Phe Asp Asn Ala Asp Gly 
65                  70                  75                  80  


Arg Phe Glu Gly Thr Ser Thr Lys Thr Val Ile Arg Tyr Asn Gly Thr 
                85                  90                  95      


Val Thr Trp Thr Pro Pro Ala Asn Tyr Lys Ser Ser Cys Thr Ile Asp 
            100                 105                 110         


Val Thr Phe Phe Pro Phe Asp Leu Gln Asn Cys Ser Met Lys Phe Gly 
        115                 120                 125             


Ser Trp Thr Tyr Asp Gly Ser Gln Val Asp Ile Ile Leu Glu Asp Gln 
    130                 135                 140                 


Asp Val Asp Lys Arg Asp Phe Phe Asp Asn Gly Glu Trp Glu Ile Val 
145                 150                 155                 160 


Ser Ala Thr Gly Ser Lys Gly Asn Arg Thr Asp Ser Cys Cys Trp Leu 
                165                 170                 175     


Leu Lys Ile Gly Asn Ser 
            180         


<210>  2875
<211>  56
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2875

Xaa Thr Leu Ser Ile Met Val Thr Val Phe Ala Ile Asn Ile His His 
1               5                   10                  15      


Arg Ser Ser Ser Thr His Asn Ala Met Ala Pro Leu Val Arg Lys Ile 
            20                  25                  30          


Phe Leu His Thr Leu Pro Lys Leu Leu Cys Met Arg Ser His Val Asp 
        35                  40                  45              


Arg Leu Leu Lys Ile Gly Asn Ser 
    50                  55      


<210>  2876
<211>  429
<212>  PRT
<213>  Homo Sapiens

<400>  2876

Met Ser Thr Lys Val Tyr Leu Asp Leu Glu Trp Thr Asp Tyr Arg Leu 
1               5                   10                  15      


Ser Trp Asp Pro Ala Glu His Asp Gly Ile Asp Ser Leu Arg Ile Thr 
            20                  25                  30          


Ala Glu Ser Val Trp Leu Pro Asp Val Val Leu Leu Asn Asn Asn Asp 
        35                  40                  45              


Gly Asn Phe Asp Val Ala Leu Asp Ile Ser Val Val Val Ser Ser Asp 
    50                  55                  60                  


Gly Ser Val Arg Trp Gln Pro Pro Gly Ile Tyr Arg Ser Ser Cys Ser 
65                  70                  75                  80  


Ile Gln Val Thr Tyr Phe Pro Phe Asp Trp Gln Asn Cys Thr Met Val 
                85                  90                  95      


Phe Ser Ser Tyr Ser Tyr Asp Ser Ser Glu Val Ser Leu Gln Thr Gly 
            100                 105                 110         


Leu Gly Pro Asp Gly Gln Gly His Gln Glu Ile His Ile His Glu Gly 
        115                 120                 125             


Thr Phe Ile Glu Asn Gly Gln Trp Glu Ile Ile His Lys Pro Ser Arg 
    130                 135                 140                 


Leu Ile Gln Pro Pro Gly Asp Pro Arg Gly Gly Arg Glu Gly Gln Arg 
145                 150                 155                 160 


Gln Glu Val Ile Phe Tyr Leu Ile Ile Arg Arg Lys Pro Leu Phe Tyr 
                165                 170                 175     


Leu Val Asn Val Ile Ala Pro Cys Ile Leu Ile Thr Leu Leu Ala Ile 
            180                 185                 190         


Phe Val Phe Tyr Leu Pro Pro Asp Ala Gly Glu Lys Met Gly Leu Ser 
        195                 200                 205             


Ile Phe Ala Leu Leu Thr Leu Thr Val Phe Leu Leu Leu Leu Ala Asp 
    210                 215                 220                 


Lys Val Pro Glu Thr Ser Leu Ser Val Pro Ile Ile Ile Lys Tyr Leu 
225                 230                 235                 240 


Met Phe Thr Met Val Leu Val Thr Phe Ser Val Ile Leu Ser Val Val 
                245                 250                 255     


Val Leu Asn Leu His His Arg Ser Pro His Thr His Gln Met Pro Leu 
            260                 265                 270         


Trp Val Arg Gln Ile Phe Ile His Lys Leu Pro Leu Tyr Leu Arg Leu 
        275                 280                 285             


Lys Arg Pro Lys Pro Glu Arg Asp Leu Met Pro Glu Pro Pro His Cys 
    290                 295                 300                 


Ser Ser Pro Gly Ser Gly Trp Gly Arg Gly Thr Asp Glu Tyr Phe Ile 
305                 310                 315                 320 


Arg Lys Pro Pro Ser Asp Phe Leu Phe Pro Lys Pro Asn Arg Phe Gln 
                325                 330                 335     


Pro Glu Leu Ser Ala Pro Asp Leu Arg Arg Phe Ile Asp Gly Pro Asn 
            340                 345                 350         


Arg Ala Val Ala Leu Leu Pro Glu Leu Arg Glu Val Val Ser Ser Ile 
        355                 360                 365             


Ser Tyr Ile Ala Arg Gln Leu Gln Glu Gln Glu Asp His Asp Ala Leu 
    370                 375                 380                 


Lys Glu Asp Trp Gln Phe Val Ala Met Val Val Asp Arg Leu Phe Leu 
385                 390                 395                 400 


Trp Thr Phe Ile Ile Phe Thr Ser Val Gly Thr Leu Val Ile Phe Leu 
                405                 410                 415     


Asp Ala Thr Tyr His Leu Pro Pro Pro Asp Pro Phe Pro 
            420                 425                 


<210>  2877
<211>  380
<212>  PRT
<213>  Homo Sapiens

<400>  2877

Met Ser Thr Lys Val Tyr Leu Asp Leu Glu Trp Thr Asp Tyr Arg Leu 
1               5                   10                  15      


Ser Trp Asp Pro Ala Glu His Asp Gly Ile Asp Ser Leu Arg Ile Thr 
            20                  25                  30          


Ala Glu Ser Val Trp Leu Pro Asp Val Val Leu Leu Asn Asn Asn Asp 
        35                  40                  45              


Gly Asn Phe Asp Val Ala Leu Asp Ile Ser Val Val Val Ser Ser Asp 
    50                  55                  60                  


Gly Ser Val Arg Trp Gln Pro Pro Gly Ile Tyr Arg Ser Ser Cys Ser 
65                  70                  75                  80  


Ile Gln Val Thr Tyr Phe Pro Phe Asp Trp Gln Asn Cys Thr Met Val 
                85                  90                  95      


Phe Ser Ser Tyr Ser Tyr Asp Ser Ser Glu Val Ser Leu Gln Thr Gly 
            100                 105                 110         


Leu Gly Pro Asp Gly Gln Gly His Gln Glu Ile His Ile His Glu Gly 
        115                 120                 125             


Thr Phe Ile Glu Asn Gly Gln Trp Glu Ile Ile His Lys Pro Ser Arg 
    130                 135                 140                 


Leu Ile Gln Pro Pro Gly Asp Pro Arg Gly Gly Arg Glu Gly Gln Arg 
145                 150                 155                 160 


Gln Glu Val Ile Phe Tyr Leu Ile Ile Arg Arg Lys Pro Leu Phe Tyr 
                165                 170                 175     


Leu Val Asn Val Ile Ala Pro Cys Ile Leu Ile Thr Leu Leu Ala Ile 
            180                 185                 190         


Phe Val Phe Tyr Leu Pro Pro Asp Ala Val Ile Leu Ser Val Val Val 
        195                 200                 205             


Leu Asn Leu His His Arg Ser Pro His Thr His Gln Met Pro Leu Trp 
    210                 215                 220                 


Val Arg Gln Ile Phe Ile His Lys Leu Pro Leu Tyr Leu Arg Leu Lys 
225                 230                 235                 240 


Arg Pro Lys Pro Glu Arg Asp Leu Met Pro Glu Pro Pro His Cys Ser 
                245                 250                 255     


Ser Pro Gly Ser Gly Trp Gly Arg Gly Thr Asp Glu Tyr Phe Ile Arg 
            260                 265                 270         


Lys Pro Pro Ser Asp Phe Leu Phe Pro Lys Pro Asn Arg Phe Gln Pro 
        275                 280                 285             


Glu Leu Ser Ala Pro Asp Leu Arg Arg Phe Ile Asp Gly Pro Asn Arg 
    290                 295                 300                 


Ala Val Ala Leu Leu Pro Glu Leu Arg Glu Val Val Ser Ser Ile Ser 
305                 310                 315                 320 


Tyr Ile Ala Arg Gln Leu Gln Glu Gln Glu Asp His Asp Ala Leu Lys 
                325                 330                 335     


Glu Asp Trp Gln Phe Val Ala Met Val Val Asp Arg Leu Phe Leu Trp 
            340                 345                 350         


Thr Phe Ile Ile Phe Thr Ser Val Gly Thr Leu Val Ile Phe Leu Asp 
        355                 360                 365             


Ala Thr Tyr His Leu Pro Pro Pro Asp Pro Phe Pro 
    370                 375                 380 


<210>  2878
<211>  158
<212>  PRT
<213>  Homo Sapiens

<400>  2878

Met Thr Pro Gly Ala Leu Leu Met Leu Leu Gly Ala Leu Gly Ala Pro 
1               5                   10                  15      


Leu Ala Pro Gly Val Arg Gly Ser Glu Ala Glu Gly Arg Leu Arg Glu 
            20                  25                  30          


Lys Leu Phe Ser Gly Tyr Asp Ser Ser Val Arg Pro Ala Arg Glu Val 
        35                  40                  45              


Gly Asp Arg Val Arg Val Ser Val Gly Leu Ile Leu Ala Gln Leu Ile 
    50                  55                  60                  


Ser Leu Asn Glu Lys Asp Glu Glu Met Ser Thr Lys Val Tyr Leu Asp 
65                  70                  75                  80  


Leu Ala Val Leu Glu Cys Gly Gly Ser Ser His Pro Pro Ala Ser Gly 
                85                  90                  95      


Gly Thr Ser Thr Ser Ala Glu Ile Thr Ala Glu Trp Thr Asp Tyr Arg 
            100                 105                 110         


Leu Ser Trp Asp Pro Ala Glu His Asp Gly Ile Asp Ser Leu Arg Ile 
        115                 120                 125             


Thr Ala Glu Ser Val Trp Leu Pro Asp Val Val Leu Leu Asn Asn Asn 
    130                 135                 140                 


Asp Gly Asn Phe Asp Val Ala Leu Asp Ile Ser Val Val Val 
145                 150                 155             


<210>  2879
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  2879

Met Thr Pro Gly Ala Leu Leu Met Leu Leu Gly Ala Leu Gly Ala Pro 
1               5                   10                  15      


Leu Ala Pro Gly Val Arg Gly Ser Glu Ala Glu Gly Arg Leu Arg Glu 
            20                  25                  30          


Lys Leu Phe Ser Gly Tyr Asp Ser Ser Val Arg Pro Ala Arg Glu Val 
        35                  40                  45              


Gly Asp Arg Val Arg Val Ser Val Gly Leu Ile Leu Ala Gln Leu Ile 
    50                  55                  60                  


Ser Leu Asn Glu Lys Asp Glu Glu Met Ser Thr Lys Val Tyr Leu Asp 
65                  70                  75                  80  


Leu Glu Trp Thr Asp Tyr Arg Leu Ser Trp Asp Pro Ala Glu His Asp 
                85                  90                  95      


Gly Ile Asp Ser Leu Arg Ile Thr Ala Glu Ser Val Trp Leu Pro Asp 
            100                 105                 110         


Val Val Leu Leu Asn Asn Asn Asp Gly Asn Phe Asp Val Ala Leu Asp 
        115                 120                 125             


Ile Ser Val Val Val Ser Ser Asp Gly Ser Val Arg Trp Gln Pro Pro 
    130                 135                 140                 


Gly Ile Tyr Arg Ser Ser Cys Ser Ile Gln Val Thr Tyr Phe Pro Phe 
145                 150                 155                 160 


Asp Trp Gln Asn Cys Thr Met Val Phe Ser Ser Tyr Ser Tyr Asp Ser 
                165                 170                 175     


Ser Glu Val Ser Leu Gln Thr Gly Leu Gly Pro Asp Gly Gln Gly His 
            180                 185                 190         


Gln Glu Ile His Ile His Glu Gly Thr Phe Ile Glu Asn Gly Gln Trp 
        195                 200                 205             


Glu Ile Ile His Lys Pro Ser Arg Leu Ile Gln Pro Pro Gly Asp Pro 
    210                 215                 220                 


Arg Gly Gly Arg Glu Gly Gln Arg Gln Glu Val Ile Phe Tyr Leu Ile 
225                 230                 235                 240 


Ile Arg Arg Lys Pro Leu Phe Tyr Leu Val Asn Val Ile Ala Pro Cys 
                245                 250                 255     


Ile Leu Ile Thr Leu Leu Ala Ile Phe Val Phe Tyr Leu Pro Pro Asp 
            260                 265                 270         


Ala Gly Glu Lys Met Gly Leu Ser Ile Phe Ala Leu Leu Thr Leu Thr 
        275                 280                 285             


Val Phe Leu Leu Leu Leu Ala Asp Lys Val Pro Glu Thr Ser Leu Ser 
    290                 295                 300                 


Val Pro Ile Ile Ile Lys Tyr Leu Met Phe Thr Met Val Leu Val Thr 
305                 310                 315                 320 


Phe Ser Val Ile Leu Ser Val Val Val Leu Asn Leu His His Arg Ser 
                325                 330                 335     


Pro His Thr His Gln Met Pro Leu Trp Val Arg Gln Ile Phe Ile His 
            340                 345                 350         


Lys Leu Pro Leu Tyr Leu Arg Leu Lys Arg Pro Lys Pro Glu Arg Asp 
        355                 360                 365             


Leu Met Pro Glu Pro Pro His Cys Ser Ser Pro Gly Ser Gly Trp Gly 
    370                 375                 380                 


Arg Gly Thr Asp Glu Tyr Phe Ile Arg Lys Pro Pro Ser Asp Phe Leu 
385                 390                 395                 400 


Phe Pro Lys Pro Asn Arg Phe Gln Pro Glu Leu Ser Ala Pro Asp Leu 
                405                 410                 415     


Arg Arg Phe Ile Asp Gly Pro Asn Arg Ala Val Ala Leu Leu Pro Glu 
            420                 425                 430         


Leu Arg Glu Val Val Ser Ser Ile Ser Tyr Ile Ala Arg Gln Leu Gln 
        435                 440                 445             


Glu Gln Glu Asp His Asp Ala Leu Lys Glu Asp Trp Gln Phe Val Ala 
    450                 455                 460                 


Met Val Val Asp Arg Leu Phe Leu Trp Thr Phe Ile Ile Phe Thr Ser 
465                 470                 475                 480 


Val Gly Thr Leu Val Ile Phe Leu Asp Ala Thr Tyr His Leu Pro Pro 
                485                 490                 495     


Pro Asp Pro Phe Pro 
            500     


<210>  2880
<211>  37
<212>  PRT
<213>  Homo Sapiens

<400>  2880

Met Val Val Asp Arg Leu Phe Leu Trp Thr Phe Ile Ile Phe Thr Ser 
1               5                   10                  15      


Val Gly Thr Leu Val Ile Phe Leu Asp Ala Thr Tyr His Leu Pro Pro 
            20                  25                  30          


Pro Asp Pro Phe Pro 
        35          


<210>  2881
<211>  316
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2881

Xaa Pro Ala Arg Glu Val Gly Asp Arg Val Arg Val Ser Val Gly Leu 
1               5                   10                  15      


Ile Leu Ala Gln Leu Ile Ser Leu Asn Glu Lys Asp Glu Glu Met Ser 
            20                  25                  30          


Thr Lys Val Tyr Leu Asp Leu Glu Trp Thr Asp Tyr Arg Leu Ser Trp 
        35                  40                  45              


Asp Pro Ala Glu His Asp Gly Ile Asp Ser Leu Arg Ile Thr Ala Glu 
    50                  55                  60                  


Ser Val Trp Leu Pro Asp Val Val Leu Leu Asn Asn Asn Asp Gly Asn 
65                  70                  75                  80  


Phe Asp Val Ala Leu Asp Ile Ser Val Val Val Ser Ser Asp Gly Ser 
                85                  90                  95      


Val Arg Trp Gln Pro Pro Gly Ile Tyr Arg Ser Ser Cys Ser Ile Gln 
            100                 105                 110         


Val Thr Tyr Phe Pro Phe Asp Trp Gln Asn Cys Thr Met Val Phe Ser 
        115                 120                 125             


Ser Tyr Ser Tyr Asp Ser Ser Glu Val Ser Leu Gln Thr Gly Leu Gly 
    130                 135                 140                 


Pro Asp Gly Gln Gly His Gln Glu Ile His Ile His Glu Gly Thr Phe 
145                 150                 155                 160 


Ile Gly Glu Lys Met Gly Leu Ser Ile Phe Ala Leu Leu Thr Leu Thr 
                165                 170                 175     


Val Phe Leu Leu Leu Leu Ala Asp Lys Val Pro Glu Thr Ser Leu Ser 
            180                 185                 190         


Val Pro Ile Ile Ile Lys Tyr Leu Met Phe Thr Met Val Leu Val Thr 
        195                 200                 205             


Phe Ser Val Ile Leu Ser Val Val Val Leu Asn Leu His His Arg Ser 
    210                 215                 220                 


Pro His Thr His Gln Met Pro Leu Trp Val Arg Gln Ile Phe Ile His 
225                 230                 235                 240 


Lys Leu Pro Leu Tyr Leu Arg Leu Lys Arg Pro Lys Pro Glu Arg Asp 
                245                 250                 255     


Leu Met Pro Glu Pro Pro His Cys Ser Ser Pro Gly Ser Gly Trp Gly 
            260                 265                 270         


Arg Gly Thr Asp Glu Tyr Phe Ile Arg Lys Pro Pro Ser Asp Phe Leu 
        275                 280                 285             


Phe Pro Lys Pro Asn Arg Phe Gln Pro Glu Leu Ser Ala Pro Asp Leu 
    290                 295                 300                 


Arg Arg Phe Ile Asp Gly Pro Asn Arg Ala Val Ala 
305                 310                 315     


<210>  2882
<211>  172
<212>  PRT
<213>  Homo Sapiens

<400>  2882

Met Glu Gly Pro Val Leu Thr Leu Gly Leu Leu Ala Ala Leu Ala Val 
1               5                   10                  15      


Cys Gly Ser Trp Gly Leu Asn Glu Glu Glu Arg Leu Ile Arg His Leu 
            20                  25                  30          


Phe Gln Glu Lys Gly Tyr Asn Lys Glu Leu Arg Pro Val Ala His Lys 
        35                  40                  45              


Glu Glu Ser Val Asp Val Ala Leu Ala Leu Thr Leu Ser Asn Leu Ile 
    50                  55                  60                  


Ser Leu Gly Trp Thr Asp Asn Arg Leu Lys Trp Asn Ala Glu Glu Phe 
65                  70                  75                  80  


Gly Asn Ile Ser Val Leu Arg Leu Pro Pro Asp Met Val Trp Leu Pro 
                85                  90                  95      


Glu Ile Val Leu Glu Asn Asn Asn Asp Gly Ser Phe Gln Ile Ser Tyr 
            100                 105                 110         


Ser Cys Asn Val Leu Val Tyr His Tyr Gly Phe Val Tyr Trp Leu Pro 
        115                 120                 125             


Pro Ala Ile Phe Arg Ser Ser Cys Pro Ile Ser Val Thr Tyr Phe Pro 
    130                 135                 140                 


Phe Asp Trp Gln Asn Cys Ser Leu Lys Phe Ser Ser Leu Lys Tyr Thr 
145                 150                 155                 160 


Ala Lys Glu Ile Thr Leu Ser Leu Lys Gln Asp Ala 
                165                 170         


<210>  2883
<211>  502
<212>  PRT
<213>  Homo Sapiens

<400>  2883

Met Glu Gly Pro Val Leu Thr Leu Gly Leu Leu Ala Ala Leu Ala Val 
1               5                   10                  15      


Cys Gly Ser Trp Gly Leu Asn Glu Glu Glu Arg Leu Ile Arg His Leu 
            20                  25                  30          


Phe Gln Glu Lys Gly Tyr Asn Lys Glu Leu Arg Pro Val Ala His Lys 
        35                  40                  45              


Glu Glu Ser Val Asp Val Ala Leu Ala Leu Thr Leu Ser Asn Leu Ile 
    50                  55                  60                  


Ser Leu Gly Trp Thr Asp Asn Arg Leu Lys Trp Asn Ala Glu Glu Phe 
65                  70                  75                  80  


Gly Asn Ile Ser Val Leu Arg Leu Pro Pro Asp Met Val Trp Leu Pro 
                85                  90                  95      


Glu Ile Val Leu Glu Asn Asn Asn Asp Gly Ser Phe Gln Ile Ser Tyr 
            100                 105                 110         


Ser Cys Asn Val Leu Val Tyr His Tyr Gly Phe Val Tyr Trp Leu Pro 
        115                 120                 125             


Pro Ala Ile Phe Arg Ser Ser Cys Pro Ile Ser Val Thr Tyr Phe Pro 
    130                 135                 140                 


Phe Asp Trp Gln Asn Cys Ser Leu Lys Phe Ser Ser Leu Lys Tyr Thr 
145                 150                 155                 160 


Ala Lys Glu Ile Thr Leu Ser Leu Lys Gln Asp Ala Lys Glu Asn Arg 
                165                 170                 175     


Thr Tyr Pro Val Glu Trp Ile Ile Ile Asp Pro Glu Gly Phe Thr Glu 
            180                 185                 190         


Asn Gly Glu Trp Glu Ile Val His Arg Pro Ala Arg Val Asn Val Asp 
        195                 200                 205             


Pro Arg Ala Pro Leu Asp Ser Pro Ser Arg Gln Asp Ile Thr Phe Tyr 
    210                 215                 220                 


Leu Ile Ile Arg Arg Lys Pro Leu Phe Tyr Ile Ile Asn Ile Leu Val 
225                 230                 235                 240 


Pro Cys Val Leu Ile Ser Phe Met Val Asn Leu Val Phe Tyr Leu Pro 
                245                 250                 255     


Ala Asp Ser Gly Glu Lys Thr Ser Val Ala Ile Ser Val Leu Leu Ala 
            260                 265                 270         


Gln Ser Val Phe Leu Leu Leu Ile Ser Lys Arg Leu Pro Ala Thr Ser 
        275                 280                 285             


Met Ala Ile Pro Leu Ile Gly Lys Phe Leu Leu Phe Gly Met Val Leu 
    290                 295                 300                 


Val Thr Met Val Val Val Ile Cys Val Ile Val Leu Asn Ile His Phe 
305                 310                 315                 320 


Arg Thr Pro Ser Thr His Val Leu Ser Glu Gly Val Lys Lys Leu Phe 
                325                 330                 335     


Leu Glu Thr Leu Pro Glu Leu Leu His Met Ser Arg Pro Ala Glu Asp 
            340                 345                 350         


Gly Pro Ser Pro Gly Ala Leu Val Arg Arg Ser Ser Ser Leu Gly Tyr 
        355                 360                 365             


Ile Ser Lys Ala Glu Glu Tyr Phe Leu Leu Lys Ser Arg Ser Asp Leu 
    370                 375                 380                 


Met Phe Glu Lys Gln Ser Glu Arg His Gly Leu Ala Arg Arg Leu Thr 
385                 390                 395                 400 


Thr Ala Arg Arg Pro Pro Ala Ser Ser Glu Gln Ala Gln Gln Glu Leu 
                405                 410                 415     


Phe Asn Glu Leu Lys Pro Ala Val Asp Gly Ala Asn Phe Ile Val Asn 
            420                 425                 430         


His Met Arg Asp Gln Asn Asn Tyr Asn Glu Glu Lys Asp Ser Trp Asn 
        435                 440                 445             


Arg Val Ala Arg Thr Val Asp Arg Leu Cys Leu Phe Val Val Thr Pro 
    450                 455                 460                 


Val Met Val Val Gly Thr Ala Trp Ile Phe Leu Gln Gly Val Tyr Asn 
465                 470                 475                 480 


Gln Pro Pro Pro Gln Pro Phe Pro Gly Asp Pro Tyr Ser Tyr Asn Val 
                485                 490                 495     


Gln Asp Lys Arg Phe Ile 
            500         


<210>  2884
<211>  108
<212>  PRT
<213>  Homo Sapiens

<400>  2884

Met Glu Gly Pro Val Leu Thr Leu Gly Leu Leu Ala Ala Leu Ala Val 
1               5                   10                  15      


Cys Gly Ser Trp Gly Leu Asn Glu Glu Glu Arg Leu Ile Arg His Leu 
            20                  25                  30          


Phe Gln Glu Lys Gly Tyr Asn Lys Glu Leu Arg Pro Val Ala His Lys 
        35                  40                  45              


Glu Glu Ser Val Asp Val Ala Leu Ala Leu Thr Leu Ser Asn Leu Ile 
    50                  55                  60                  


Ser Leu Lys Glu Val Glu Glu Thr Leu Thr Thr Asn Val Trp Ile Glu 
65                  70                  75                  80  


His Gly Trp Thr Asp Asn Arg Leu Lys Trp Asn Ala Glu Glu Phe Gly 
                85                  90                  95      


Asn Ile Ser Val Leu Arg Leu Pro Pro Asp Met Gln 
            100                 105             


<210>  2885
<211>  235
<212>  PRT
<213>  Homo Sapiens

<400>  2885

Met Glu Gly Pro Val Leu Thr Leu Gly Leu Leu Ala Ala Leu Ala Val 
1               5                   10                  15      


Cys Gly Ser Trp Gly Leu Asn Glu Glu Glu Arg Leu Ile Arg His Leu 
            20                  25                  30          


Phe Gln Glu Lys Gly Tyr Asn Lys Glu Leu Arg Pro Val Ala His Lys 
        35                  40                  45              


Glu Glu Ser Val Asp Val Ala Leu Ala Leu Thr Leu Ser Asn Leu Ile 
    50                  55                  60                  


Ser Leu Lys Glu Val Glu Glu Thr Leu Thr Thr Asn Val Trp Ile Glu 
65                  70                  75                  80  


His Gly Trp Thr Asp Asn Arg Leu Lys Trp Asn Ala Glu Glu Phe Gly 
                85                  90                  95      


Asn Ile Ser Val Leu Arg Leu Pro Pro Asp Met Val Trp Leu Pro Glu 
            100                 105                 110         


Ile Val Leu Glu Asn Asn Asn Asp Gly Ser Phe Gln Ile Ser Tyr Ser 
        115                 120                 125             


Cys Asn Val Leu Val Tyr His Tyr Gly Phe Val Tyr Trp Leu Pro Pro 
    130                 135                 140                 


Ala Ile Phe Arg Ser Ser Cys Pro Ile Ser Val Thr Tyr Phe Pro Phe 
145                 150                 155                 160 


Asp Trp Gln Asn Cys Ser Leu Lys Phe Arg Glu Arg Gly Val Gly Asp 
                165                 170                 175     


Ser Pro Pro Ala Gly Gln Gly Gln Arg Gly Pro Gln Ser Pro Ser Gly 
            180                 185                 190         


Gln Pro Gln Pro Pro Gly His His Leu Leu Pro His His Pro Pro Gln 
        195                 200                 205             


Ala Pro Leu Leu His His Gln His Pro Gly Ala Leu Arg Ala His Leu 
    210                 215                 220                 


Leu His Gly Gln Pro Gly Leu Leu Pro Thr Gly 
225                 230                 235 


<210>  2886
<211>  171
<212>  PRT
<213>  Homo Sapiens

<400>  2886

Met Glu Gly Pro Val Leu Thr Leu Gly Leu Leu Ala Ala Leu Ala Val 
1               5                   10                  15      


Cys Gly Ser Trp Gly Leu Asn Glu Glu Glu Arg Leu Ile Arg His Leu 
            20                  25                  30          


Phe Gln Glu Lys Gly Tyr Asn Lys Glu Leu Arg Pro Val Ala His Lys 
        35                  40                  45              


Glu Glu Ser Val Asp Val Ala Leu Ala Leu Thr Leu Ser Asn Leu Ile 
    50                  55                  60                  


Ser Leu Lys Glu Val Glu Glu Thr Leu Thr Thr Asn Val Trp Ile Glu 
65                  70                  75                  80  


His Gly Trp Thr Asp Asn Arg Leu Lys Trp Asn Ala Glu Glu Phe Gly 
                85                  90                  95      


Asn Ile Ser Val Leu Arg Leu Pro Pro Asp Met Val Trp Leu Pro Glu 
            100                 105                 110         


Ile Val Leu Glu Asn Asn Asn Asp Gly Ser Phe Gln Ile Ser Tyr Ser 
        115                 120                 125             


Cys Asn Val Leu Val Tyr His Tyr Gly Phe Val Tyr Trp Leu Pro Pro 
    130                 135                 140                 


Ala Ile Phe Arg Ser Ser Cys Pro Ile Ser Val Thr Tyr Phe Pro Phe 
145                 150                 155                 160 


Asp Trp Gln Asn Cys Ser Leu Lys Phe Arg Trp 
                165                 170     


<210>  2887
<211>  517
<212>  PRT
<213>  Homo Sapiens

<400>  2887

Met Glu Gly Pro Val Leu Thr Leu Gly Leu Leu Ala Ala Leu Ala Val 
1               5                   10                  15      


Cys Gly Ser Trp Gly Leu Asn Glu Glu Glu Arg Leu Ile Arg His Leu 
            20                  25                  30          


Phe Gln Glu Lys Gly Tyr Asn Lys Glu Leu Arg Pro Val Ala His Lys 
        35                  40                  45              


Glu Glu Ser Val Asp Val Ala Leu Ala Leu Thr Leu Ser Asn Leu Ile 
    50                  55                  60                  


Ser Leu Lys Glu Val Glu Glu Thr Leu Thr Thr Asn Val Trp Ile Glu 
65                  70                  75                  80  


His Gly Trp Thr Asp Asn Arg Leu Lys Trp Asn Ala Glu Glu Phe Gly 
                85                  90                  95      


Asn Ile Ser Val Leu Arg Leu Pro Pro Asp Met Val Trp Leu Pro Glu 
            100                 105                 110         


Ile Val Leu Glu Asn Asn Asn Asp Gly Ser Phe Gln Ile Ser Tyr Ser 
        115                 120                 125             


Cys Asn Val Leu Val Tyr His Tyr Gly Phe Val Tyr Trp Leu Pro Pro 
    130                 135                 140                 


Ala Ile Phe Arg Ser Ser Cys Pro Ile Ser Val Thr Tyr Phe Pro Phe 
145                 150                 155                 160 


Asp Trp Gln Asn Cys Ser Leu Lys Phe Ser Ser Leu Lys Tyr Thr Ala 
                165                 170                 175     


Lys Glu Ile Thr Leu Ser Leu Lys Gln Asp Ala Lys Glu Asn Arg Thr 
            180                 185                 190         


Tyr Pro Val Glu Trp Ile Ile Ile Asp Pro Glu Gly Phe Thr Glu Asn 
        195                 200                 205             


Gly Glu Trp Glu Ile Val His Arg Pro Ala Arg Val Asn Val Asp Pro 
    210                 215                 220                 


Arg Ala Pro Leu Asp Ser Pro Ser Arg Gln Asp Ile Thr Phe Tyr Leu 
225                 230                 235                 240 


Ile Ile Arg Arg Lys Pro Leu Phe Tyr Ile Ile Asn Ile Leu Val Pro 
                245                 250                 255     


Cys Val Leu Ile Ser Phe Met Val Asn Leu Val Phe Tyr Leu Pro Ala 
            260                 265                 270         


Asp Ser Gly Glu Lys Thr Ser Val Ala Ile Ser Val Leu Leu Ala Gln 
        275                 280                 285             


Ser Val Phe Leu Leu Leu Ile Ser Lys Arg Leu Pro Ala Thr Ser Met 
    290                 295                 300                 


Ala Ile Pro Leu Ile Gly Lys Phe Leu Leu Phe Gly Met Val Leu Val 
305                 310                 315                 320 


Thr Met Val Val Val Ile Cys Val Ile Val Leu Asn Ile His Phe Arg 
                325                 330                 335     


Thr Pro Ser Thr His Val Leu Ser Glu Gly Val Lys Lys Leu Phe Leu 
            340                 345                 350         


Glu Thr Leu Pro Glu Leu Leu His Met Ser Arg Pro Ala Glu Asp Gly 
        355                 360                 365             


Pro Ser Pro Gly Ala Leu Val Arg Arg Ser Ser Ser Leu Gly Tyr Ile 
    370                 375                 380                 


Ser Lys Ala Glu Glu Tyr Phe Leu Leu Lys Ser Arg Ser Asp Leu Met 
385                 390                 395                 400 


Phe Glu Lys Gln Ser Glu Arg His Gly Leu Ala Arg Arg Leu Thr Thr 
                405                 410                 415     


Ala Arg Arg Pro Pro Ala Ser Ser Glu Gln Ala Gln Gln Glu Leu Phe 
            420                 425                 430         


Asn Glu Leu Lys Pro Ala Val Asp Gly Ala Asn Phe Ile Val Asn His 
        435                 440                 445             


Met Arg Asp Gln Asn Asn Tyr Asn Glu Glu Lys Asp Ser Trp Asn Arg 
    450                 455                 460                 


Val Ala Arg Thr Val Asp Arg Leu Cys Leu Phe Val Val Thr Pro Val 
465                 470                 475                 480 


Met Val Val Gly Thr Ala Trp Ile Phe Leu Gln Gly Val Tyr Asn Gln 
                485                 490                 495     


Pro Pro Pro Gln Pro Phe Pro Gly Asp Pro Tyr Ser Tyr Asn Val Gln 
            500                 505                 510         


Asp Lys Arg Phe Ile 
        515         


<210>  2888
<211>  411
<212>  PRT
<213>  Homo Sapiens

<400>  2888

Met Gln Cys Ser Trp Lys Ala Val Leu Leu Leu Ala Leu Ala Ser Ile 
1               5                   10                  15      


Ala Ile Gln Tyr Thr Ala Ile Arg Thr Phe Thr Ala Lys Ser Phe His 
            20                  25                  30          


Thr Cys Pro Gly Leu Ala Glu Ala Gly Leu Ala Glu Arg Leu Cys Glu 
        35                  40                  45              


Glu Ser Pro Thr Phe Ala Tyr Asn Leu Ser Arg Lys Thr His Ile Leu 
    50                  55                  60                  


Ile Leu Ala Thr Thr Arg Ser Gly Ser Ser Phe Val Gly Gln Leu Phe 
65                  70                  75                  80  


Asn Gln His Leu Asp Val Phe Tyr Leu Phe Glu Pro Leu Tyr His Val 
                85                  90                  95      


Gln Asn Thr Leu Ile Pro Arg Phe Thr Gln Gly Lys Ser Pro Ala Asp 
            100                 105                 110         


Arg Arg Val Met Leu Gly Ala Ser Arg Asp Leu Leu Arg Ser Leu Tyr 
        115                 120                 125             


Asp Cys Asp Leu Tyr Phe Leu Glu Asn Tyr Ile Lys Pro Pro Pro Val 
    130                 135                 140                 


Asn His Thr Thr Asp Arg Ile Phe Arg Arg Gly Ala Ser Arg Val Leu 
145                 150                 155                 160 


Cys Ser Arg Pro Val Cys Asp Pro Pro Gly Pro Ala Asp Leu Val Leu 
                165                 170                 175     


Glu Glu Gly Asp Cys Val Arg Lys Cys Gly Leu Leu Asn Leu Thr Val 
            180                 185                 190         


Ala Ala Glu Ala Cys Arg Glu Arg Ser His Val Ala Ile Lys Thr Val 
        195                 200                 205             


Arg Val Pro Glu Val Asn Asp Leu Arg Ala Leu Val Glu Asp Pro Arg 
    210                 215                 220                 


Leu Asn Leu Lys Val Ile Gln Leu Val Arg Asp Pro Arg Gly Ile Leu 
225                 230                 235                 240 


Ala Ser Arg Ser Glu Thr Phe Arg Asp Thr Tyr Arg Leu Trp Arg Leu 
                245                 250                 255     


Trp Tyr Gly Thr Gly Arg Lys Pro Tyr Asn Leu Asp Val Thr Gln Leu 
            260                 265                 270         


Thr Thr Val Cys Glu Asp Phe Ser Asn Ser Val Ser Thr Gly Leu Met 
        275                 280                 285             


Arg Pro Pro Trp Leu Lys Gly Lys Tyr Met Leu Val Arg Tyr Glu Asp 
    290                 295                 300                 


Leu Ala Arg Asn Pro Met Lys Lys Thr Glu Glu Ile Tyr Gly Phe Leu 
305                 310                 315                 320 


Gly Ile Pro Leu Asp Ser His Val Ala Arg Trp Ile Gln Asn Asn Thr 
                325                 330                 335     


Arg Gly Asp Pro Thr Leu Gly Lys His Lys Tyr Gly Thr Val Arg Asn 
            340                 345                 350         


Ser Ala Ala Thr Ala Glu Lys Trp Arg Phe Arg Leu Ser Tyr Asp Ile 
        355                 360                 365             


Val Ala Phe Ala Gln Asn Ala Cys Gln Gln Val Leu Ala Gln Leu Gly 
    370                 375                 380                 


Tyr Lys Ile Ala Ala Ser Glu Glu Glu Leu Lys Asn Pro Ser Val Ser 
385                 390                 395                 400 


Leu Val Glu Glu Arg Asp Phe Arg Pro Phe Ser 
                405                 410     


<210>  2889
<211>  33
<212>  PRT
<213>  Homo Sapiens

<400>  2889

Met His His Gln Trp Leu Leu Leu Ala Ala Cys Phe Trp Val Ile Phe 
1               5                   10                  15      


Met Phe Met Val Ala Ser Lys Phe Ile Thr Leu Thr Phe Lys Asp Pro 
            20                  25                  30          


Asp 
    


<210>  2890
<211>  64
<212>  PRT
<213>  Homo Sapiens

<400>  2890

Met His His Gln Trp Leu Leu Leu Ala Ala Cys Phe Trp Val Ile Phe 
1               5                   10                  15      


Met Phe Met Val Ala Ser Lys Phe Ile Thr Leu Thr Phe Lys Asp Pro 
            20                  25                  30          


Asp Val Tyr Ser Ala Lys Gln Glu Phe Leu Phe Leu Thr Thr Met Pro 
        35                  40                  45              


Glu Val Arg Lys Leu Pro Glu Glu Lys His Ile Pro Glu Glu Leu Lys 
    50                  55                  60                  


<210>  2891
<211>  85
<212>  PRT
<213>  Homo Sapiens

<400>  2891

Met His His Gln Trp Leu Leu Leu Ala Ala Cys Phe Trp Val Ile Phe 
1               5                   10                  15      


Met Phe Met Val Ala Ser Lys Phe Ile Thr Leu Thr Phe Lys Asp Pro 
            20                  25                  30          


Asp Val Tyr Ser Ala Lys Gln Glu Phe Leu Phe Leu Thr Thr Met Pro 
        35                  40                  45              


Glu Val Arg Lys Leu Pro Glu Glu Lys His Ile Pro Glu Glu Leu Lys 
    50                  55                  60                  


Pro Thr Gly Lys Glu Leu Pro Asp Ser Gln Leu Val Gln Pro Leu Val 
65                  70                  75                  80  


Tyr Met Glu Arg Leu 
                85  


<210>  2892
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  2892

Met His His Gln Trp Leu Leu Leu Ala Ala Cys Phe Trp Val Ile Phe 
1               5                   10                  15      


Met Phe Met Val Ala Ser Lys Phe Ile Thr Leu Thr Phe Lys Asp Pro 
            20                  25                  30          


Asp Val Tyr Ser Ala Lys Gln Glu Phe Leu Phe Leu Thr Thr Met Pro 
        35                  40                  45              


Glu Val Arg Lys Leu Pro Glu Glu Lys His Ile Pro Glu Glu Leu Lys 
    50                  55                  60                  


Pro Thr Gly Lys Glu Leu Pro Asp Ser Gln Leu Val Gln Pro Leu Val 
65                  70                  75                  80  


Tyr Met Glu Arg Leu Glu Leu Ile Arg Asn Val Cys Arg Asp Asp Ala 
                85                  90                  95      


Leu Lys Asn Leu Ser His Thr Pro Val Ser Lys Phe Val Leu Asp Arg 
            100                 105                 110         


Ile Phe Val Cys Asp Lys His Lys Ile Leu Phe Cys Gln Thr Pro Lys 
        115                 120                 125             


Val Gly Asn Thr Gln 
    130             


<210>  2893
<211>  141
<212>  PRT
<213>  Homo Sapiens

<400>  2893

Met His His Gln Trp Leu Leu Leu Ala Ala Cys Phe Trp Val Ile Phe 
1               5                   10                  15      


Met Phe Met Val Ala Ser Lys Phe Ile Thr Leu Thr Phe Lys Asp Pro 
            20                  25                  30          


Asp Val Tyr Ser Ala Lys Gln Glu Phe Leu Phe Leu Thr Thr Met Pro 
        35                  40                  45              


Glu Val Arg Lys Leu Pro Glu Glu Lys His Ile Pro Glu Glu Leu Lys 
    50                  55                  60                  


Pro Thr Gly Lys Glu Leu Pro Asp Ser Gln Leu Val Gln Pro Leu Val 
65                  70                  75                  80  


Tyr Met Glu Arg Leu Glu Leu Ile Arg Asn Val Cys Arg Asp Asp Ala 
                85                  90                  95      


Leu Lys Asn Leu Ser His Thr Pro Val Ser Lys Phe Val Leu Asp Arg 
            100                 105                 110         


Ile Phe Val Cys Asp Lys His Lys Ile Leu Phe Cys Gln Thr Pro Lys 
        115                 120                 125             


Val Gly Asn Thr Gln Trp Lys Lys Val Leu Ile Val Leu 
    130                 135                 140     


<210>  2894
<211>  356
<212>  PRT
<213>  Homo Sapiens

<400>  2894

Met His His Gln Trp Leu Leu Leu Ala Ala Cys Phe Trp Val Ile Phe 
1               5                   10                  15      


Met Phe Met Val Ala Ser Lys Phe Ile Thr Leu Thr Phe Lys Asp Pro 
            20                  25                  30          


Asp Val Tyr Ser Ala Lys Gln Glu Phe Leu Phe Leu Thr Thr Met Pro 
        35                  40                  45              


Glu Val Arg Lys Leu Pro Glu Glu Lys His Ile Pro Glu Glu Leu Lys 
    50                  55                  60                  


Pro Thr Gly Lys Glu Leu Pro Asp Ser Gln Leu Val Gln Pro Leu Val 
65                  70                  75                  80  


Tyr Met Glu Arg Leu Glu Leu Ile Arg Asn Val Cys Arg Asp Asp Ala 
                85                  90                  95      


Leu Lys Asn Leu Ser His Thr Pro Val Ser Lys Phe Val Leu Asp Arg 
            100                 105                 110         


Ile Phe Val Cys Asp Lys His Lys Ile Leu Phe Cys Gln Thr Pro Lys 
        115                 120                 125             


Val Gly Asn Thr Gln Trp Lys Lys Val Leu Ile Val Leu Asn Gly Ala 
    130                 135                 140                 


Phe Ser Ser Ile Glu Glu Ile Pro Glu Asn Val Val His Asp His Glu 
145                 150                 155                 160 


Lys Asn Gly Leu Pro Arg Leu Ser Ser Phe Ser Asp Ala Glu Ile Gln 
                165                 170                 175     


Lys Arg Leu Lys Thr Tyr Phe Lys Phe Phe Ile Val Arg Asp Pro Phe 
            180                 185                 190         


Glu Arg Leu Ile Ser Ala Phe Lys Asp Lys Phe Val His Asn Pro Arg 
        195                 200                 205             


Phe Glu Pro Trp Tyr Arg His Glu Ile Ala Pro Gly Ile Ile Arg Lys 
    210                 215                 220                 


Tyr Arg Arg Asn Arg Thr Glu Thr Arg Gly Ile Gln Phe Glu Asp Phe 
225                 230                 235                 240 


Val Arg Tyr Leu Gly Asp Pro Asn His Arg Trp Leu Asp Leu Gln Phe 
                245                 250                 255     


Gly Asp His Ile Ile His Trp Val Thr Tyr Val Glu Leu Cys Ala Pro 
            260                 265                 270         


Cys Glu Ile Met Tyr Ser Val Ile Gly His His Glu Thr Leu Glu Asp 
        275                 280                 285             


Asp Ala Pro Tyr Ile Leu Lys Glu Ala Gly Ile Asp His Leu Val Ser 
    290                 295                 300                 


Tyr Pro Thr Ile Pro Pro Gly Ile Thr Val Tyr Asn Arg Thr Lys Val 
305                 310                 315                 320 


Glu His Tyr Phe Leu Gly Ile Ser Lys Arg Asp Ile Arg Arg Leu Tyr 
                325                 330                 335     


Ala Arg Phe Glu Gly Asp Phe Lys Leu Phe Gly Tyr Gln Lys Pro Asp 
            340                 345                 350         


Phe Leu Leu Asn 
        355     


<210>  2895
<211>  356
<212>  PRT
<213>  Homo Sapiens

<400>  2895

Met His His Gln Trp Leu Leu Leu Ala Ala Cys Phe Trp Val Ile Phe 
1               5                   10                  15      


Met Phe Met Val Ala Ser Lys Phe Ile Thr Leu Thr Phe Lys Asp Pro 
            20                  25                  30          


Asp Val Tyr Ser Ala Lys Gln Glu Phe Leu Phe Leu Thr Thr Met Pro 
        35                  40                  45              


Glu Val Arg Lys Leu Pro Glu Glu Lys His Ile Pro Glu Glu Leu Lys 
    50                  55                  60                  


Pro Thr Gly Lys Glu Leu Pro Asp Ser Gln Leu Val Gln Pro Leu Val 
65                  70                  75                  80  


Tyr Met Glu Arg Leu Glu Leu Ile Arg Asn Val Cys Arg Asp Asp Ala 
                85                  90                  95      


Leu Lys Asn Leu Ser His Thr Pro Val Ser Lys Phe Val Leu Asp Arg 
            100                 105                 110         


Ile Phe Val Cys Asp Lys His Lys Ile Leu Phe Cys Gln Thr Pro Lys 
        115                 120                 125             


Val Gly Asn Thr Gln Trp Lys Lys Val Leu Ile Val Leu Asn Gly Ala 
    130                 135                 140                 


Phe Ser Ser Ile Glu Glu Ile Pro Glu Asn Val Val His Asp His Glu 
145                 150                 155                 160 


Lys Asn Gly Leu Pro Arg Leu Ser Ser Phe Ser Asp Ala Glu Ile Gln 
                165                 170                 175     


Lys Arg Leu Lys Thr Tyr Phe Lys Phe Phe Ile Val Arg Asp Pro Phe 
            180                 185                 190         


Glu Arg Leu Ile Ser Ala Phe Lys Asp Lys Phe Val His Asn Pro Arg 
        195                 200                 205             


Phe Glu Pro Trp Tyr Arg His Glu Ile Ala Pro Gly Ile Ile Arg Lys 
    210                 215                 220                 


Tyr Arg Arg Asn Arg Thr Glu Thr Arg Gly Ile Gln Phe Glu Asp Phe 
225                 230                 235                 240 


Val Arg Tyr Leu Gly Asp Pro Asn His Arg Trp Leu Asp Leu Gln Phe 
                245                 250                 255     


Gly Asp His Ile Ile His Trp Val Thr Tyr Val Glu Leu Cys Ala Pro 
            260                 265                 270         


Cys Glu Ile Met Tyr Ser Val Ile Gly His His Glu Thr Leu Glu Asp 
        275                 280                 285             


Asp Ala Pro Tyr Ile Leu Lys Glu Ala Gly Ile Asp His Leu Val Ser 
    290                 295                 300                 


Tyr Pro Thr Ile Pro Pro Gly Ile Thr Val Tyr Asn Arg Thr Lys Val 
305                 310                 315                 320 


Glu His Tyr Phe Leu Gly Ile Ser Lys Arg Asp Ile Arg Arg Leu Tyr 
                325                 330                 335     


Ala Arg Phe Glu Gly Asp Phe Lys Leu Phe Gly Tyr Gln Lys Pro Asp 
            340                 345                 350         


Phe Leu Leu Asn 
        355     


<210>  2896
<211>  142
<212>  PRT
<213>  Homo Sapiens

<400>  2896

Met Gln Arg Lys Ala Gly Lys Lys Glu His Val Gln Leu Arg Asp Lys 
1               5                   10                  15      


Arg Asn Gln Glu Pro Gln Phe Arg Gly Asn Thr Ala Arg Lys Cys Glu 
            20                  25                  30          


Pro Gln Ala Ala Glu Gly Arg Val Ser Glu Trp Leu Arg Cys Asp Asn 
        35                  40                  45              


Met His His Gln Trp Leu Leu Leu Ala Ala Cys Phe Trp Val Ile Phe 
    50                  55                  60                  


Met Phe Met Val Ala Ser Lys Phe Ile Thr Leu Thr Phe Lys Asp Pro 
65                  70                  75                  80  


Asp Val Tyr Ser Ala Lys Gln Glu Phe Leu Phe Leu Thr Thr Met Pro 
                85                  90                  95      


Glu Val Arg Lys Leu Pro Glu Glu Lys His Ile Pro Glu Glu Leu Lys 
            100                 105                 110         


Pro Thr Gly Lys Glu Leu Pro Asp Ser Gln Leu Val Gln Pro Leu Val 
        115                 120                 125             


Tyr Met Glu Arg Leu Glu Leu Ile Arg Asn Val Cys Arg Asp 
    130                 135                 140         


<210>  2897
<211>  347
<212>  PRT
<213>  Homo Sapiens

<400>  2897

Met Lys Pro Ala Leu Leu Glu Val Met Arg Met Asn Arg Ile Cys Arg 
1               5                   10                  15      


Met Val Leu Ala Thr Cys Leu Gly Ser Phe Ile Leu Val Ile Phe Tyr 
            20                  25                  30          


Phe Gln Ile Met Arg Arg Asn Pro Phe Gly Val Asp Ile Cys Cys Arg 
        35                  40                  45              


Lys Gly Ser Arg Ser Pro Leu Gln Glu Leu Tyr Asn Pro Ile Gln Leu 
    50                  55                  60                  


Glu Leu Ser Asn Thr Ala Val Leu His Gln Met Arg Arg Asp Gln Val 
65                  70                  75                  80  


Thr Asp Thr Cys Arg Ala Asn Ser Ala Thr Ser Arg Lys Arg Arg Val 
                85                  90                  95      


Leu Thr Pro Asn Asp Leu Lys His Leu Val Val Asp Glu Asp His Glu 
            100                 105                 110         


Leu Ile Tyr Cys Tyr Val Pro Lys Val Ala Cys Thr Asn Trp Lys Arg 
        115                 120                 125             


Leu Met Met Val Leu Thr Gly Arg Gly Lys Tyr Ser Asp Pro Met Glu 
    130                 135                 140                 


Ile Pro Ala Asn Glu Ala His Val Ser Ala Asn Leu Lys Thr Leu Asn 
145                 150                 155                 160 


Gln Tyr Ser Ile Pro Glu Ile Asn His Arg Leu Lys Ser Tyr Met Lys 
                165                 170                 175     


Phe Leu Phe Val Arg Glu Pro Phe Glu Arg Leu Val Ser Ala Tyr Arg 
            180                 185                 190         


Asn Lys Phe Thr Gln Lys Tyr Asn Ile Ser Phe His Lys Arg Tyr Gly 
        195                 200                 205             


Thr Lys Ile Ile Lys Arg Gln Arg Lys Asn Ala Thr Gln Glu Ala Leu 
    210                 215                 220                 


Arg Lys Gly Asp Asp Val Lys Phe Glu Glu Phe Val Ala Tyr Leu Ile 
225                 230                 235                 240 


Asp Pro His Thr Gln Arg Glu Glu Pro Phe Asn Glu His Trp Gln Thr 
                245                 250                 255     


Val Tyr Ser Leu Cys His Pro Cys His Ile His Tyr Asp Leu Val Gly 
            260                 265                 270         


Lys Tyr Glu Thr Leu Glu Glu Asp Ser Asn Tyr Val Leu Gln Leu Ala 
        275                 280                 285             


Gly Val Gly Ser Tyr Leu Lys Phe Pro Thr Tyr Ala Lys Ser Thr Arg 
    290                 295                 300                 


Thr Thr Asp Glu Met Thr Thr Glu Phe Phe Gln Asn Ile Ser Ser Glu 
305                 310                 315                 320 


His Gln Thr Gln Leu Tyr Glu Val Tyr Lys Leu Asp Phe Leu Met Phe 
                325                 330                 335     


Asn Tyr Ser Val Pro Ser Tyr Leu Lys Leu Glu 
            340                 345         


<210>  2898
<211>  72
<212>  PRT
<213>  Homo Sapiens

<400>  2898

Met Lys Pro Ala Leu Leu Glu Val Met Arg Met Asn Arg Ile Cys Arg 
1               5                   10                  15      


Met Val Leu Ala Thr Cys Leu Gly Ser Phe Ile Leu Val Ile Phe Tyr 
            20                  25                  30          


Phe Gln Ile Met Arg Arg Asn Pro Phe Gly Val Asp Ile Cys Cys Arg 
        35                  40                  45              


Lys Gly Ser Arg Ser Pro Leu Gln Glu Leu Tyr Asn Pro Ile Gln Val 
    50                  55                  60                  


Ser Phe Lys His Ser Val Ser Met 
65                  70          


<210>  2899
<211>  352
<212>  PRT
<213>  Homo Sapiens

<400>  2899

Met Lys Pro Ala Leu Leu Glu Val Met Arg Met Asn Arg Ile Cys Arg 
1               5                   10                  15      


Met Val Leu Ala Thr Cys Leu Gly Ser Phe Ile Leu Val Ile Phe Tyr 
            20                  25                  30          


Phe Gln Ser Met Leu His Pro Val Met Arg Arg Asn Pro Phe Gly Val 
        35                  40                  45              


Asp Ile Cys Cys Arg Lys Gly Ser Arg Ser Pro Leu Gln Glu Leu Tyr 
    50                  55                  60                  


Asn Pro Ile Gln Leu Glu Leu Ser Asn Thr Ala Val Leu His Gln Met 
65                  70                  75                  80  


Arg Arg Asp Gln Val Thr Asp Thr Cys Arg Ala Asn Ser Ala Thr Ser 
                85                  90                  95      


Arg Lys Arg Arg Val Leu Thr Pro Asn Asp Leu Lys His Leu Val Val 
            100                 105                 110         


Asp Glu Asp His Glu Leu Ile Tyr Cys Tyr Val Pro Lys Val Ala Cys 
        115                 120                 125             


Thr Asn Trp Lys Arg Leu Met Met Val Leu Thr Gly Arg Gly Lys Tyr 
    130                 135                 140                 


Ser Asp Pro Met Glu Ile Pro Ala Asn Glu Ala His Val Ser Ala Asn 
145                 150                 155                 160 


Leu Lys Thr Leu Asn Gln Tyr Ser Ile Pro Glu Ile Asn His Arg Leu 
                165                 170                 175     


Lys Ser Tyr Met Lys Phe Leu Phe Val Arg Glu Pro Phe Glu Arg Leu 
            180                 185                 190         


Val Ser Ala Tyr Arg Asn Lys Phe Thr Gln Lys Tyr Asn Ile Ser Phe 
        195                 200                 205             


His Lys Arg Tyr Gly Thr Lys Ile Ile Lys Arg Gln Arg Lys Asn Ala 
    210                 215                 220                 


Thr Gln Glu Ala Leu Arg Lys Gly Asp Asp Val Lys Phe Glu Glu Phe 
225                 230                 235                 240 


Val Ala Tyr Leu Ile Asp Pro His Thr Gln Arg Glu Glu Pro Phe Asn 
                245                 250                 255     


Glu His Trp Gln Thr Val Tyr Ser Leu Cys His Pro Cys His Ile His 
            260                 265                 270         


Tyr Asp Leu Val Gly Lys Tyr Glu Thr Leu Glu Glu Asp Ser Asn Tyr 
        275                 280                 285             


Val Leu Gln Leu Ala Gly Val Gly Ser Tyr Leu Lys Phe Pro Thr Tyr 
    290                 295                 300                 


Ala Lys Ser Thr Arg Thr Thr Asp Glu Met Thr Thr Glu Phe Phe Gln 
305                 310                 315                 320 


Asn Ile Ser Ser Glu His Gln Thr Gln Leu Tyr Glu Val Tyr Lys Leu 
                325                 330                 335     


Asp Phe Leu Met Phe Asn Tyr Ser Val Pro Ser Tyr Leu Lys Leu Glu 
            340                 345                 350         


<210>  2900
<211>  77
<212>  PRT
<213>  Homo Sapiens

<400>  2900

Met Lys Pro Ala Leu Leu Glu Val Met Arg Met Asn Arg Ile Cys Arg 
1               5                   10                  15      


Met Val Leu Ala Thr Cys Leu Gly Ser Phe Ile Leu Val Ile Phe Tyr 
            20                  25                  30          


Phe Gln Ser Met Leu His Pro Val Met Arg Arg Asn Pro Phe Gly Val 
        35                  40                  45              


Asp Ile Cys Cys Arg Lys Gly Ser Arg Ser Pro Leu Gln Glu Leu Tyr 
    50                  55                  60                  


Asn Pro Ile Gln Val Ser Phe Lys His Ser Val Ser Met 
65                  70                  75          


<210>  2901
<211>  158
<212>  PRT
<213>  Homo Sapiens

<400>  2901

Met Arg Arg Asn Pro Phe Gly Val Asp Ile Cys Cys Arg Lys Gly Ser 
1               5                   10                  15      


Arg Ser Pro Leu Gln Glu Leu Tyr Asn Pro Ile Gln Leu Glu Leu Ser 
            20                  25                  30          


Asn Thr Ala Val Leu His Gln Met Arg Arg Asp Gln Val Thr Asp Thr 
        35                  40                  45              


Cys Arg Ala Asn Ser Ala Thr Ser Arg Lys Arg Arg Val Leu Thr Pro 
    50                  55                  60                  


Asn Asp Leu Lys His Leu Val Val Asp Glu Asp His Glu Leu Ile Tyr 
65                  70                  75                  80  


Cys Tyr Val Pro Lys Val Ala Cys Thr Asn Trp Lys Arg Leu Met Met 
                85                  90                  95      


Val Leu Thr Gly Arg Gly Lys Tyr Ser Asp Pro Met Glu Ile Pro Ala 
            100                 105                 110         


Asn Glu Ala His Val Ser Ala Asn Leu Lys Thr Leu Asn Gln Tyr Ser 
        115                 120                 125             


Ile Pro Glu Ile Asn His Arg Leu Lys Ser Tyr Met Lys Phe Leu Phe 
    130                 135                 140                 


Val Arg Glu Pro Phe Glu Arg Leu Val Ser Ala Tyr Arg Asn 
145                 150                 155             


<210>  2902
<211>  225
<212>  PRT
<213>  Homo Sapiens

<400>  2902

Met Gly Arg Arg Cys Cys Arg Arg Arg Val Leu Ala Ala Ala Cys Leu 
1               5                   10                  15      


Gly Ala Ala Leu Leu Leu Leu Cys Ala Ala Pro Arg Ser Leu Arg Pro 
            20                  25                  30          


Ala Phe Gly Asn Arg Ala Leu Gly Ser Ser Trp Leu Gly Gly Glu Lys 
        35                  40                  45              


Arg Ser Pro Leu Gln Lys Leu Tyr Asp Leu Asp Gln Asp Pro Arg Ser 
    50                  55                  60                  


Thr Leu Ala Lys Val His Arg Gln Arg Arg Asp Leu Leu Asn Ser Ala 
65                  70                  75                  80  


Cys Ser Arg His Ser Arg Arg Gln Arg Leu Leu Gln Pro Glu Asp Leu 
                85                  90                  95      


Arg His Val Leu Val Asp Asp Ala His Gly Leu Leu Tyr Cys Tyr Val 
            100                 105                 110         


Pro Lys Val Ala Cys Thr Asn Trp Lys Arg Val Leu Leu Ala Leu Ser 
        115                 120                 125             


Gly Gln Ala Arg Gly Asp Pro Arg Ala Ile Ser Ala Gln Glu Ala His 
    130                 135                 140                 


Ala Pro Gly Arg Leu Pro Ser Leu Ala Asp Phe Ser Pro Ala Glu Ile 
145                 150                 155                 160 


Asn Arg Arg Leu Arg Ala Tyr Leu Ala Phe Leu Phe Val Arg Glu Pro 
                165                 170                 175     


Phe Glu Arg Leu Ala Ser Ala Tyr Arg Asn Lys Leu Ala Arg Pro Arg 
            180                 185                 190         


Ser Ala Thr Arg Val Ala Ser Ala Thr Thr Ser Trp Ala Ser Ser Arg 
        195                 200                 205             


Arg Trp Arg Arg Thr Arg Pro Ser Cys Trp Ala Trp Arg Ala His Pro 
    210                 215                 220                 


Thr 
225 


<210>  2903
<211>  341
<212>  PRT
<213>  Homo Sapiens

<400>  2903

Met Gly Arg Arg Cys Cys Arg Arg Arg Val Leu Ala Ala Ala Cys Leu 
1               5                   10                  15      


Gly Ala Ala Leu Leu Leu Leu Cys Ala Ala Pro Arg Ser Leu Arg Pro 
            20                  25                  30          


Ala Phe Gly Asn Arg Ala Leu Gly Ser Ser Trp Leu Gly Gly Glu Lys 
        35                  40                  45              


Arg Ser Pro Leu Gln Lys Leu Tyr Asp Leu Asp Gln Asp Pro Arg Ser 
    50                  55                  60                  


Thr Leu Ala Lys Val His Arg Gln Arg Arg Asp Leu Leu Asn Ser Ala 
65                  70                  75                  80  


Cys Ser Arg His Ser Arg Arg Gln Arg Leu Leu Gln Pro Glu Asp Leu 
                85                  90                  95      


Arg His Val Leu Val Asp Asp Ala His Gly Leu Leu Tyr Cys Tyr Val 
            100                 105                 110         


Pro Lys Val Ala Cys Thr Asn Trp Lys Arg Val Leu Leu Ala Leu Ser 
        115                 120                 125             


Gly Gln Ala Arg Gly Asp Pro Arg Ala Ile Ser Ala Gln Glu Ala His 
    130                 135                 140                 


Ala Pro Gly Arg Leu Pro Ser Leu Ala Asp Phe Ser Pro Ala Glu Ile 
145                 150                 155                 160 


Asn Arg Arg Leu Arg Ala Tyr Leu Ala Phe Leu Phe Val Arg Glu Pro 
                165                 170                 175     


Phe Glu Arg Leu Ala Ser Ala Tyr Arg Asn Lys Leu Ala Arg Pro Tyr 
            180                 185                 190         


Ser Ala Ala Phe Gln Arg Arg Tyr Gly Ala Arg Ile Val Gln Arg Leu 
        195                 200                 205             


Arg Pro Arg Ala Leu Pro Asp Ala Arg Ala Arg Gly His Asp Val Arg 
    210                 215                 220                 


Phe Ala Glu Phe Leu Ala Tyr Leu Leu Asp Pro Arg Thr Arg Arg Glu 
225                 230                 235                 240 


Glu Pro Phe Asn Glu His Trp Glu Arg Ala His Ala Leu Cys His Pro 
                245                 250                 255     


Cys Arg Leu Arg Tyr Asp Val Val Gly Lys Phe Glu Thr Leu Ala Glu 
            260                 265                 270         


Asp Ala Ala Phe Val Leu Gly Leu Ala Gly Ala Ser Asp Leu Ser Phe 
        275                 280                 285             


Pro Gly Pro Pro Arg Pro Arg Gly Ala Ala Ala Ser Arg Asp Leu Ala 
    290                 295                 300                 


Ala Arg Leu Phe Arg Asp Ile Ser Pro Phe Tyr Gln Arg Arg Leu Phe 
305                 310                 315                 320 


Asp Leu Tyr Lys Met Asp Phe Leu Leu Phe Asn Tyr Ser Ala Pro Ser 
                325                 330                 335     


Tyr Leu Arg Leu Leu 
            340     


<210>  2904
<211>  386
<212>  PRT
<213>  Homo Sapiens

<400>  2904

Met Leu Leu Pro Lys Lys Met Lys Leu Leu Leu Phe Leu Val Ser Gln 
1               5                   10                  15      


Met Ala Ile Leu Ala Leu Phe Phe His Met Tyr Ser His Asn Ile Ser 
            20                  25                  30          


Ser Leu Ser Met Lys Ala Gln Pro Glu Arg Met His Val Leu Val Leu 
        35                  40                  45              


Ser Ser Trp Arg Ser Gly Ser Ser Phe Val Gly Gln Leu Phe Gly Gln 
    50                  55                  60                  


His Pro Asp Val Phe Tyr Leu Met Glu Pro Ala Trp His Val Trp Met 
65                  70                  75                  80  


Thr Phe Lys Gln Ser Thr Ala Trp Met Leu His Met Ala Val Arg Asp 
                85                  90                  95      


Leu Ile Arg Ala Val Phe Leu Cys Asp Met Ser Val Phe Asp Ala Tyr 
            100                 105                 110         


Met Glu Pro Gly Pro Arg Arg Gln Ser Ser Leu Phe Gln Trp Glu Asn 
        115                 120                 125             


Ser Arg Ala Leu Cys Ser Ala Pro Ala Cys Asp Ile Ile Pro Gln Asp 
    130                 135                 140                 


Glu Ile Ile Pro Arg Ala His Cys Arg Leu Leu Cys Ser Gln Gln Pro 
145                 150                 155                 160 


Phe Glu Val Val Glu Lys Ala Cys Arg Ser Tyr Ser His Val Val Leu 
                165                 170                 175     


Lys Glu Val Arg Phe Phe Asn Leu Gln Ser Leu Tyr Pro Leu Leu Lys 
            180                 185                 190         


Asp Pro Ser Leu Asn Leu His Ile Val His Leu Val Arg Asp Pro Arg 
        195                 200                 205             


Ala Val Phe Arg Ser Arg Glu Arg Thr Lys Gly Asp Leu Met Ile Asp 
    210                 215                 220                 


Ser Arg Ile Val Met Gly Gln His Glu Gln Lys Leu Lys Lys Glu Asp 
225                 230                 235                 240 


Gln Pro Tyr Tyr Val Met Gln Val Ile Cys Gln Ser Gln Leu Glu Ile 
                245                 250                 255     


Tyr Lys Thr Ile Gln Ser Leu Pro Lys Ala Leu Gln Glu Arg Tyr Leu 
            260                 265                 270         


Leu Val Arg Tyr Glu Asp Leu Ala Arg Ala Pro Val Ala Gln Thr Ser 
        275                 280                 285             


Arg Met Tyr Glu Phe Val Gly Leu Glu Phe Leu Pro His Leu Gln Thr 
    290                 295                 300                 


Trp Val His Asn Ile Thr Arg Gly Lys Gly Met Gly Asp His Ala Phe 
305                 310                 315                 320 


His Thr Asn Ala Arg Asp Ala Leu Asn Val Ser Gln Ala Trp Arg Trp 
                325                 330                 335     


Ser Leu Pro Tyr Glu Lys Val Ser Arg Leu Gln Lys Ala Cys Gly Asp 
            340                 345                 350         


Ala Met Asn Leu Leu Gly Tyr Arg His Val Arg Ser Glu Gln Glu Gln 
        355                 360                 365             


Arg Asn Leu Leu Leu Asp Leu Leu Ser Thr Trp Thr Val Pro Glu Gln 
    370                 375                 380                 


Ile His 
385     


<210>  2905
<211>  386
<212>  PRT
<213>  Homo Sapiens

<400>  2905

Met Leu Leu Pro Lys Lys Met Lys Leu Leu Leu Phe Leu Val Ser Gln 
1               5                   10                  15      


Met Ala Ile Leu Ala Leu Phe Phe His Met Tyr Ser His Asn Ile Ser 
            20                  25                  30          


Ser Leu Ser Met Lys Ala Gln Pro Glu Arg Met His Val Leu Val Leu 
        35                  40                  45              


Ser Ser Trp Arg Ser Gly Ser Ser Phe Val Gly Gln Leu Phe Gly Gln 
    50                  55                  60                  


His Pro Asp Val Phe Tyr Leu Met Glu Pro Ala Trp His Val Trp Met 
65                  70                  75                  80  


Thr Phe Lys Gln Ser Thr Ala Trp Met Leu His Met Ala Val Arg Asp 
                85                  90                  95      


Leu Ile Arg Ala Val Phe Leu Cys Asp Met Ser Val Phe Asp Ala Tyr 
            100                 105                 110         


Met Glu Pro Gly Pro Arg Arg Gln Ser Ser Leu Phe Gln Trp Glu Asn 
        115                 120                 125             


Ser Arg Ala Leu Cys Ser Ala Pro Ala Cys Asp Ile Ile Pro Gln Asp 
    130                 135                 140                 


Glu Ile Ile Pro Arg Ala His Cys Arg Leu Leu Cys Ser Gln Gln Pro 
145                 150                 155                 160 


Phe Glu Val Val Glu Lys Ala Cys Arg Ser Tyr Ser His Val Val Leu 
                165                 170                 175     


Lys Glu Val Arg Phe Phe Asn Leu Gln Ser Leu Tyr Pro Leu Leu Lys 
            180                 185                 190         


Asp Pro Ser Leu Asn Leu His Ile Val His Leu Val Arg Asp Pro Arg 
        195                 200                 205             


Ala Val Phe Arg Ser Arg Glu Arg Thr Lys Gly Asp Leu Met Ile Asp 
    210                 215                 220                 


Ser Arg Ile Val Met Gly Gln His Glu Gln Lys Leu Lys Lys Glu Asp 
225                 230                 235                 240 


Gln Pro Tyr Tyr Val Met Gln Val Ile Cys Gln Ser Gln Leu Glu Ile 
                245                 250                 255     


Tyr Lys Thr Ile Gln Ser Leu Pro Lys Ala Leu Gln Glu Arg Tyr Leu 
            260                 265                 270         


Leu Val Arg Tyr Glu Asp Leu Ala Arg Ala Pro Val Ala Gln Thr Ser 
        275                 280                 285             


Arg Met Tyr Glu Phe Val Gly Leu Glu Phe Leu Pro His Leu Gln Thr 
    290                 295                 300                 


Trp Val His Asn Ile Thr Arg Gly Lys Gly Met Gly Asp His Ala Phe 
305                 310                 315                 320 


His Thr Asn Ala Arg Asp Ala Leu Asn Val Ser Gln Ala Trp Arg Trp 
                325                 330                 335     


Ser Leu Pro Tyr Glu Lys Val Ser Arg Leu Gln Lys Ala Cys Gly Asp 
            340                 345                 350         


Ala Met Asn Leu Leu Gly Tyr Arg His Val Arg Ser Glu Gln Glu Gln 
        355                 360                 365             


Arg Asn Leu Leu Leu Asp Leu Leu Ser Thr Trp Thr Val Pro Glu Gln 
    370                 375                 380                 


Ile His 
385     


<210>  2906
<211>  411
<212>  PRT
<213>  Homo Sapiens

<400>  2906

Met Gly Met Arg Ala Arg Val Pro Lys Val Ala His Ser Thr Arg Arg 
1               5                   10                  15      


Pro Pro Ala Ala Arg Met Trp Leu Pro Arg Phe Ser Ser Lys Thr Val 
            20                  25                  30          


Thr Val Leu Leu Leu Ala Gln Thr Thr Cys Leu Leu Leu Phe Ile Ile 
        35                  40                  45              


Ser Arg Pro Gly Pro Ser Ser Pro Ala Gly Gly Glu Asp Arg Val His 
    50                  55                  60                  


Val Leu Val Leu Ser Ser Trp Arg Ser Gly Ser Ser Phe Leu Gly Gln 
65                  70                  75                  80  


Leu Phe Ser Gln His Pro Asp Val Phe Tyr Leu Met Glu Pro Ala Trp 
                85                  90                  95      


His Val Trp Thr Thr Leu Ser Gln Gly Ser Ala Ala Thr Leu His Met 
            100                 105                 110         


Ala Val Arg Asp Leu Met Arg Ser Ile Phe Leu Cys Asp Met Asp Val 
        115                 120                 125             


Phe Asp Ala Tyr Met Pro Gln Ser Arg Asn Leu Ser Ala Phe Phe Asn 
    130                 135                 140                 


Trp Ala Thr Ser Arg Ala Leu Cys Ser Pro Pro Ala Cys Ser Ala Phe 
145                 150                 155                 160 


Pro Arg Gly Thr Ile Ser Lys Gln Asp Val Cys Lys Thr Leu Cys Thr 
                165                 170                 175     


Arg Gln Pro Phe Ser Leu Ala Arg Glu Ala Cys Arg Ser Tyr Ser His 
            180                 185                 190         


Val Val Leu Lys Glu Val Arg Phe Phe Asn Leu Gln Val Leu Tyr Pro 
        195                 200                 205             


Leu Leu Ser Asp Pro Ala Leu Asn Leu Arg Ile Val His Leu Val Arg 
    210                 215                 220                 


Asp Pro Arg Ala Val Leu Arg Ser Arg Glu Ala Ala Gly Pro Ile Leu 
225                 230                 235                 240 


Ala Arg Asp Asn Gly Ile Val Leu Gly Thr Asn Gly Lys Trp Val Glu 
                245                 250                 255     


Ala Asp Pro His Leu Arg Leu Ile Arg Glu Val Cys Arg Ser His Val 
            260                 265                 270         


Arg Ile Ala Glu Ala Ala Thr Leu Lys Pro Pro Pro Phe Leu Arg Gly 
        275                 280                 285             


Arg Tyr Arg Leu Val Arg Phe Glu Asp Leu Ala Arg Glu Pro Leu Ala 
    290                 295                 300                 


Glu Ile Arg Ala Leu Tyr Ala Phe Thr Gly Leu Thr Leu Thr Pro Gln 
305                 310                 315                 320 


Leu Glu Ala Trp Ile His Asn Ile Thr His Gly Ser Gly Ile Gly Lys 
                325                 330                 335     


Pro Ile Glu Ala Phe His Thr Ser Ser Arg Asn Ala Arg Asn Val Ser 
            340                 345                 350         


Gln Ala Trp Arg His Ala Leu Pro Phe Thr Lys Ile Leu Arg Val Gln 
        355                 360                 365             


Glu Val Cys Ala Gly Ala Leu Gln Leu Leu Gly Tyr Arg Pro Val Tyr 
    370                 375                 380                 


Ser Ala Asp Gln Gln Arg Asp Leu Thr Leu Asp Leu Val Leu Pro Arg 
385                 390                 395                 400 


Gly Pro Asp His Phe Ser Trp Ala Ser Pro Asp 
                405                 410     


<210>  2907
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  2907

Met Ser Arg His Leu Pro Trp Ile Cys Asp Gln Arg Cys Ser Ser Pro 
1               5                   10                  15      


Ser Ser Pro Gly Arg Trp Pro Pro Ala Ala Arg Met Trp Leu Pro Arg 
            20                  25                  30          


Phe Ser Ser Lys Thr Val Thr Val Leu Leu Leu Ala Gln Thr Thr Cys 
        35                  40                  45              


Leu Leu Leu Phe Ile Ile Ser Arg Pro Gly Pro Ser Ser Pro Ala Gly 
    50                  55                  60                  


Gly Glu Asp Arg Val His Val Leu Val Leu Ser Ser Trp Arg Ser Gly 
65                  70                  75                  80  


Ser Ser Phe Leu Gly Gln Leu Phe Ser Gln His Pro Asp Val Phe Tyr 
                85                  90                  95      


Leu Met Glu 
            


<210>  2908
<211>  395
<212>  PRT
<213>  Homo Sapiens

<400>  2908

Met Trp Leu Pro Arg Val Ser Ser Thr Ala Val Thr Ala Leu Leu Leu 
1               5                   10                  15      


Ala Gln Thr Phe Leu Leu Leu Phe Leu Val Ser Arg Pro Gly Pro Ser 
            20                  25                  30          


Ser Pro Ala Gly Gly Glu Ala Arg Val His Val Leu Val Leu Ser Ser 
        35                  40                  45              


Trp Arg Ser Gly Ser Ser Phe Val Gly Gln Leu Phe Asn Gln His Pro 
    50                  55                  60                  


Asp Val Phe Tyr Leu Met Glu Pro Ala Trp His Val Trp Thr Thr Leu 
65                  70                  75                  80  


Ser Gln Gly Ser Ala Ala Thr Leu His Met Ala Val Arg Asp Leu Val 
                85                  90                  95      


Arg Ser Val Phe Leu Cys Asp Met Asp Val Phe Asp Ala Tyr Leu Pro 
            100                 105                 110         


Trp Arg Arg Asn Leu Ser Asp Leu Phe Gln Trp Ala Val Ser Arg Ala 
        115                 120                 125             


Leu Cys Ser Pro Pro Ala Cys Ser Ala Phe Pro Arg Gly Ala Ile Ser 
    130                 135                 140                 


Ser Glu Ala Val Cys Lys Pro Leu Cys Ala Arg Gln Ser Phe Thr Leu 
145                 150                 155                 160 


Ala Arg Glu Ala Cys Arg Ser Tyr Ser His Val Val Leu Lys Glu Val 
                165                 170                 175     


Arg Phe Phe Asn Leu Gln Val Leu Tyr Pro Leu Leu Ser Asp Pro Ala 
            180                 185                 190         


Leu Asn Leu Arg Ile Val His Leu Val Arg Asp Pro Arg Ala Val Leu 
        195                 200                 205             


Arg Ser Arg Glu Gln Thr Ala Lys Ala Leu Ala Arg Asp Asn Gly Ile 
    210                 215                 220                 


Val Leu Gly Thr Asn Gly Thr Trp Val Glu Ala Asp Pro Gly Leu Arg 
225                 230                 235                 240 


Val Val Arg Glu Val Cys Arg Ser His Val Arg Ile Ala Glu Ala Ala 
                245                 250                 255     


Thr Leu Lys Pro Pro Pro Phe Leu Arg Gly Arg Tyr Arg Leu Val Arg 
            260                 265                 270         


Phe Glu Asp Leu Ala Arg Glu Pro Leu Ala Glu Ile Arg Ala Leu Tyr 
        275                 280                 285             


Ala Phe Thr Gly Leu Ser Leu Thr Pro Gln Leu Glu Ala Trp Ile His 
    290                 295                 300                 


Asn Ile Thr His Gly Ser Gly Pro Gly Ala Arg Arg Glu Ala Phe Lys 
305                 310                 315                 320 


Thr Ser Ser Arg Asn Ala Leu Asn Val Ser Gln Ala Trp Arg His Ala 
                325                 330                 335     


Leu Pro Phe Ala Lys Ile Arg Arg Val Gln Glu Leu Cys Ala Gly Ala 
            340                 345                 350         


Leu Gln Leu Leu Gly Tyr Arg Pro Val Tyr Ser Glu Asp Glu Gln Arg 
        355                 360                 365             


Asn Leu Ala Leu Asp Leu Val Leu Pro Arg Gly Leu Asn Gly Phe Thr 
    370                 375                 380                 


Trp Ala Ser Ser Thr Ala Ser His Pro Arg Asn 
385                 390                 395 


<210>  2909
<211>  395
<212>  PRT
<213>  Homo Sapiens

<400>  2909

Met Trp Leu Pro Arg Val Ser Ser Thr Ala Val Thr Ala Leu Leu Leu 
1               5                   10                  15      


Ala Gln Thr Phe Leu Leu Leu Phe Leu Val Ser Arg Pro Gly Pro Ser 
            20                  25                  30          


Ser Pro Ala Gly Gly Glu Ala Arg Val His Val Leu Val Leu Ser Ser 
        35                  40                  45              


Trp Arg Ser Gly Ser Ser Phe Val Gly Gln Leu Phe Asn Gln His Pro 
    50                  55                  60                  


Asp Val Phe Tyr Leu Met Glu Pro Ala Trp His Val Trp Thr Thr Leu 
65                  70                  75                  80  


Ser Gln Gly Ser Ala Ala Thr Leu His Met Ala Val Arg Asp Leu Val 
                85                  90                  95      


Arg Ser Val Phe Leu Cys Asp Met Asp Val Phe Asp Ala Tyr Leu Pro 
            100                 105                 110         


Trp Arg Arg Asn Leu Ser Asp Leu Phe Gln Trp Ala Val Ser Arg Ala 
        115                 120                 125             


Leu Cys Ser Pro Pro Ala Cys Ser Ala Phe Pro Arg Gly Ala Ile Ser 
    130                 135                 140                 


Ser Glu Ala Val Cys Lys Pro Leu Cys Ala Arg Gln Ser Phe Thr Leu 
145                 150                 155                 160 


Ala Arg Glu Ala Cys Arg Ser Tyr Ser His Val Val Leu Lys Glu Val 
                165                 170                 175     


Arg Phe Phe Asn Leu Gln Val Leu Tyr Pro Leu Leu Ser Asp Pro Ala 
            180                 185                 190         


Leu Asn Leu Arg Ile Val His Leu Val Arg Asp Pro Arg Ala Val Leu 
        195                 200                 205             


Arg Ser Arg Glu Gln Thr Ala Lys Ala Leu Ala Arg Asp Asn Gly Ile 
    210                 215                 220                 


Val Leu Gly Thr Asn Gly Thr Trp Val Glu Ala Asp Pro Gly Leu Arg 
225                 230                 235                 240 


Val Val Arg Glu Val Cys Arg Ser His Val Arg Ile Ala Glu Ala Ala 
                245                 250                 255     


Thr Leu Lys Pro Pro Pro Phe Leu Arg Gly Arg Tyr Arg Leu Val Arg 
            260                 265                 270         


Phe Glu Asp Leu Ala Arg Glu Pro Leu Ala Glu Ile Arg Ala Leu Tyr 
        275                 280                 285             


Ala Phe Thr Gly Leu Ser Leu Thr Pro Gln Leu Glu Ala Trp Ile His 
    290                 295                 300                 


Asn Ile Thr His Gly Ser Gly Pro Gly Ala Arg Arg Glu Ala Phe Lys 
305                 310                 315                 320 


Thr Ser Ser Arg Asn Ala Leu Asn Val Ser Gln Ala Trp Arg His Ala 
                325                 330                 335     


Leu Pro Phe Ala Lys Ile Arg Arg Val Gln Glu Leu Cys Ala Gly Ala 
            340                 345                 350         


Leu Gln Leu Leu Gly Tyr Arg Pro Val Tyr Ser Glu Asp Glu Gln Arg 
        355                 360                 365             


Asn Leu Ala Leu Asp Leu Val Leu Pro Arg Gly Leu Asn Gly Phe Thr 
    370                 375                 380                 


Trp Ala Ser Ser Thr Ala Ser His Pro Arg Asn 
385                 390                 395 


<210>  2910
<211>  486
<212>  PRT
<213>  Homo Sapiens

<400>  2910

Met Lys Gly Arg Arg Arg Arg Arg Arg Glu Tyr Cys Lys Phe Ala Leu 
1               5                   10                  15      


Leu Leu Val Leu Tyr Thr Leu Val Leu Leu Leu Val Pro Ser Val Leu 
            20                  25                  30          


Asp Gly Gly Arg Asp Gly Asp Lys Gly Ala Glu His Cys Pro Gly Leu 
        35                  40                  45              


Gln Arg Ser Leu Gly Val Trp Ser Leu Glu Ala Ala Ala Ala Gly Glu 
    50                  55                  60                  


Arg Glu Gln Gly Ala Glu Ala Arg Ala Ala Glu Glu Gly Gly Ala Asn 
65                  70                  75                  80  


Gln Ser Pro Arg Phe Pro Ser Asn Leu Ser Gly Ala Val Gly Glu Ala 
                85                  90                  95      


Val Ser Arg Glu Lys Gln His Ile Tyr Val His Ala Thr Trp Arg Thr 
            100                 105                 110         


Gly Ser Ser Phe Leu Gly Glu Leu Phe Asn Gln His Pro Asp Val Phe 
        115                 120                 125             


Tyr Leu Tyr Glu Pro Met Trp His Leu Trp Gln Ala Leu Tyr Pro Gly 
    130                 135                 140                 


Asp Ala Glu Ser Leu Gln Gly Ala Leu Arg Asp Met Leu Arg Ser Leu 
145                 150                 155                 160 


Phe Arg Cys Asp Phe Ser Val Leu Arg Leu Tyr Ala Pro Pro Gly Asp 
                165                 170                 175     


Pro Ala Ala Arg Ala Pro Asp Thr Ala Asn Leu Thr Thr Ala Ala Leu 
            180                 185                 190         


Phe Arg Trp Arg Thr Asn Lys Val Ile Cys Ser Pro Pro Leu Cys Pro 
        195                 200                 205             


Gly Ala Pro Arg Ala Arg Ala Glu Val Gly Leu Val Glu Asp Thr Ala 
    210                 215                 220                 


Cys Glu Arg Ser Cys Pro Pro Val Ala Ile Arg Ala Leu Glu Ala Glu 
225                 230                 235                 240 


Cys Arg Lys Tyr Pro Val Val Val Ile Lys Asp Val Arg Leu Leu Asp 
                245                 250                 255     


Leu Gly Val Leu Val Pro Leu Leu Arg Asp Pro Gly Leu Asn Leu Lys 
            260                 265                 270         


Val Val Gln Leu Phe Arg Asp Pro Arg Ala Val His Asn Ser Arg Leu 
        275                 280                 285             


Lys Ser Arg Gln Gly Leu Leu Arg Glu Ser Ile Gln Val Leu Arg Thr 
    290                 295                 300                 


Arg Gln Arg Gly Asp Arg Phe His Arg Val Leu Leu Ala His Gly Val 
305                 310                 315                 320 


Gly Ala Arg Pro Gly Gly Gln Ser Arg Ala Leu Pro Ala Ala Pro Arg 
                325                 330                 335     


Ala Asp Phe Phe Leu Thr Gly Ala Leu Glu Val Ile Cys Glu Ala Trp 
            340                 345                 350         


Leu Arg Asp Leu Leu Phe Ala Arg Gly Ala Pro Ala Trp Leu Arg Arg 
        355                 360                 365             


Arg Tyr Leu Arg Leu Arg Tyr Glu Asp Leu Val Arg Gln Pro Arg Ala 
    370                 375                 380                 


Gln Leu Arg Arg Leu Leu Arg Phe Ser Gly Leu Arg Ala Leu Ala Ala 
385                 390                 395                 400 


Leu Asp Ala Phe Ala Leu Asn Met Thr Arg Gly Ala Ala Tyr Gly Ala 
                405                 410                 415     


Asp Arg Pro Phe His Leu Ser Ala Arg Asp Ala Arg Glu Ala Val His 
            420                 425                 430         


Ala Trp Arg Glu Arg Leu Ser Arg Glu Gln Val Arg Gln Val Glu Ala 
        435                 440                 445             


Ala Cys Ala Pro Ala Met Arg Leu Leu Ala Tyr Pro Arg Ser Gly Glu 
    450                 455                 460                 


Glu Gly Asp Ala Glu Gln Pro Arg Glu Gly Glu Thr Pro Leu Glu Met 
465                 470                 475                 480 


Asp Ala Asp Gly Ala Thr 
                485     


<210>  2911
<211>  178
<212>  PRT
<213>  Homo Sapiens

<400>  2911

Met Thr Leu Arg Pro Gly Thr Met Arg Leu Ala Cys Met Phe Ser Ser 
1               5                   10                  15      


Ile Leu Leu Phe Gly Ala Ala Gly Leu Leu Leu Phe Ile Ser Leu Gln 
            20                  25                  30          


Asp Pro Thr Glu Leu Ala Pro Gln Gln Val Pro Gly Ile Lys Phe Asn 
        35                  40                  45              


Ile Arg Pro Arg Gln Pro His His Asp Leu Pro Pro Gly Gly Ser Gln 
    50                  55                  60                  


Asp Gly Asp Leu Lys Glu Pro Thr Glu Arg Val Thr Arg Asp Leu Ser 
65                  70                  75                  80  


Ser Gly Ala Pro Arg Gly Arg Asn Leu Pro Ala Pro Asp Gln Pro Gln 
                85                  90                  95      


Pro Pro Leu Gln Arg Gly Thr Arg Leu Arg Leu Arg Gln Arg Arg Arg 
            100                 105                 110         


Arg Leu Leu Ile Lys Lys Met Pro Ala Ala Ala Thr Ile Pro Ala Asn 
        115                 120                 125             


Ser Ser Asp Ala Pro Phe Ile Arg Pro Gly Pro Gly Thr Leu Asp Gly 
    130                 135                 140                 


Arg Trp Val Ser Leu His Arg Ser Gln Gln Glu Arg Lys Arg Val Met 
145                 150                 155                 160 


Gln Glu Ala Cys Ala Lys Tyr Arg Ala Ser Ser Ser Arg Arg Ala Val 
                165                 170                 175     


Thr Pro 
        


<210>  2912
<211>  424
<212>  PRT
<213>  Homo Sapiens

<400>  2912

Met Thr Leu Arg Pro Gly Thr Met Arg Leu Ala Cys Met Phe Ser Ser 
1               5                   10                  15      


Ile Leu Leu Phe Gly Ala Ala Gly Leu Leu Leu Phe Ile Ser Leu Gln 
            20                  25                  30          


Asp Pro Thr Glu Leu Ala Pro Gln Gln Val Pro Gly Ile Lys Phe Asn 
        35                  40                  45              


Ile Arg Pro Arg Gln Pro His His Asp Leu Pro Pro Gly Gly Ser Gln 
    50                  55                  60                  


Asp Gly Asp Leu Lys Glu Pro Thr Glu Arg Val Thr Arg Asp Leu Ser 
65                  70                  75                  80  


Ser Gly Ala Pro Arg Gly Arg Asn Leu Pro Ala Pro Asp Gln Pro Gln 
                85                  90                  95      


Pro Pro Leu Gln Arg Gly Thr Arg Leu Arg Leu Arg Gln Arg Arg Arg 
            100                 105                 110         


Arg Leu Leu Ile Lys Lys Met Pro Ala Ala Ala Thr Ile Pro Ala Asn 
        115                 120                 125             


Ser Ser Asp Ala Pro Phe Ile Arg Pro Gly Pro Gly Thr Leu Asp Gly 
    130                 135                 140                 


Arg Trp Val Ser Leu His Arg Ser Gln Gln Glu Arg Lys Arg Val Met 
145                 150                 155                 160 


Gln Glu Ala Cys Ala Lys Tyr Arg Ala Ser Ser Ser Arg Arg Ala Val 
                165                 170                 175     


Thr Pro Arg His Val Ser Arg Ile Phe Val Glu Asp Arg His Arg Val 
            180                 185                 190         


Leu Tyr Cys Glu Val Pro Lys Ala Gly Cys Ser Asn Trp Lys Arg Val 
        195                 200                 205             


Leu Met Val Leu Ala Gly Leu Ala Ser Ser Thr Ala Asp Ile Gln His 
    210                 215                 220                 


Asn Thr Val His Tyr Gly Ser Ala Leu Lys Arg Leu Asp Thr Phe Asp 
225                 230                 235                 240 


Arg Gln Gly Ile Leu His Arg Leu Ser Thr Tyr Thr Lys Met Leu Phe 
                245                 250                 255     


Val Arg Glu Pro Phe Glu Arg Leu Val Ser Ala Phe Arg Asp Lys Phe 
            260                 265                 270         


Glu His Pro Asn Ser Tyr Tyr His Pro Val Phe Gly Lys Ala Ile Leu 
        275                 280                 285             


Ala Arg Tyr Arg Ala Asn Ala Ser Arg Glu Ala Leu Arg Thr Gly Ser 
    290                 295                 300                 


Gly Val Arg Phe Pro Glu Phe Val Gln Tyr Leu Leu Asp Val His Arg 
305                 310                 315                 320 


Pro Val Gly Met Asp Ile His Trp Asp His Val Ser Arg Leu Cys Ser 
                325                 330                 335     


Pro Cys Leu Ile Asp Tyr Asp Phe Val Gly Lys Phe Glu Ser Met Glu 
            340                 345                 350         


Asp Asp Ala Asn Phe Phe Leu Ser Leu Ile Arg Ala Pro Arg Asn Leu 
        355                 360                 365             


Thr Phe Pro Arg Phe Lys Asp Arg His Ser Gln Glu Ala Arg Thr Thr 
    370                 375                 380                 


Ala Arg Ile Ala His Gln Tyr Phe Ala Gln Leu Ser Ala Leu Gln Arg 
385                 390                 395                 400 


Gln Arg Thr Tyr Asp Phe Tyr Tyr Met Asp Tyr Leu Met Phe Asn Tyr 
                405                 410                 415     


Ser Lys Pro Phe Ala Asp Leu Tyr 
            420                 


<210>  2913
<211>  424
<212>  PRT
<213>  Homo Sapiens

<400>  2913

Met Thr Leu Arg Pro Gly Thr Met Arg Leu Ala Cys Met Phe Ser Ser 
1               5                   10                  15      


Ile Leu Leu Phe Gly Ala Ala Gly Leu Leu Leu Phe Ile Ser Leu Gln 
            20                  25                  30          


Asp Pro Thr Glu Leu Ala Pro Gln Gln Val Pro Gly Ile Lys Phe Asn 
        35                  40                  45              


Ile Arg Pro Arg Gln Pro His His Asp Leu Pro Pro Gly Gly Ser Gln 
    50                  55                  60                  


Asp Gly Asp Leu Lys Glu Pro Thr Glu Arg Val Thr Arg Asp Leu Ser 
65                  70                  75                  80  


Ser Gly Ala Pro Arg Gly Arg Asn Leu Pro Ala Pro Asp Gln Pro Gln 
                85                  90                  95      


Pro Pro Leu Gln Arg Gly Thr Arg Leu Arg Leu Arg Gln Arg Arg Arg 
            100                 105                 110         


Arg Leu Leu Ile Lys Lys Met Pro Ala Ala Ala Thr Ile Pro Ala Asn 
        115                 120                 125             


Ser Ser Asp Ala Pro Phe Ile Arg Pro Gly Pro Gly Thr Leu Asp Gly 
    130                 135                 140                 


Arg Trp Val Ser Leu His Arg Ser Gln Gln Glu Arg Lys Arg Val Met 
145                 150                 155                 160 


Gln Glu Ala Cys Ala Lys Tyr Arg Ala Ser Ser Ser Arg Arg Ala Val 
                165                 170                 175     


Thr Pro Arg His Val Ser Arg Ile Phe Val Glu Asp Arg His Arg Val 
            180                 185                 190         


Leu Tyr Cys Glu Val Pro Lys Ala Gly Cys Ser Asn Trp Lys Arg Val 
        195                 200                 205             


Leu Met Val Leu Ala Gly Leu Ala Ser Ser Thr Ala Asp Ile Gln His 
    210                 215                 220                 


Asn Thr Val His Tyr Gly Ser Ala Leu Lys Arg Leu Asp Thr Phe Asp 
225                 230                 235                 240 


Arg Gln Gly Ile Leu His Arg Leu Ser Thr Tyr Thr Lys Met Leu Phe 
                245                 250                 255     


Val Arg Glu Pro Phe Glu Arg Leu Val Ser Ala Phe Arg Asp Lys Phe 
            260                 265                 270         


Glu His Pro Asn Ser Tyr Tyr His Pro Val Phe Gly Lys Ala Ile Leu 
        275                 280                 285             


Ala Arg Tyr Arg Ala Asn Ala Ser Arg Glu Ala Leu Arg Thr Gly Ser 
    290                 295                 300                 


Gly Val Arg Phe Pro Glu Phe Val Gln Tyr Leu Leu Asp Val His Arg 
305                 310                 315                 320 


Pro Val Gly Met Asp Ile His Trp Asp His Val Ser Arg Leu Cys Ser 
                325                 330                 335     


Pro Cys Leu Ile Asp Tyr Asp Phe Val Gly Lys Phe Glu Ser Met Glu 
            340                 345                 350         


Asp Asp Ala Asn Phe Phe Leu Ser Leu Ile Arg Ala Pro Arg Asn Leu 
        355                 360                 365             


Thr Phe Pro Arg Phe Lys Asp Arg His Ser Gln Glu Ala Arg Thr Thr 
    370                 375                 380                 


Ala Arg Ile Ala His Gln Tyr Phe Ala Gln Leu Ser Ala Leu Gln Arg 
385                 390                 395                 400 


Gln Arg Thr Tyr Asp Phe Tyr Tyr Met Asp Tyr Leu Met Phe Asn Tyr 
                405                 410                 415     


Ser Lys Pro Phe Ala Asp Leu Tyr 
            420                 


<210>  2914
<211>  424
<212>  PRT
<213>  Homo Sapiens

<400>  2914

Met Thr Leu Arg Pro Gly Thr Met Arg Leu Ala Cys Met Phe Ser Ser 
1               5                   10                  15      


Ile Leu Leu Phe Gly Ala Ala Gly Leu Leu Leu Phe Ile Ser Leu Gln 
            20                  25                  30          


Asp Pro Thr Glu Leu Ala Pro Gln Gln Val Pro Gly Ile Lys Phe Asn 
        35                  40                  45              


Ile Arg Pro Arg Gln Pro His His Asp Leu Pro Pro Gly Gly Ser Gln 
    50                  55                  60                  


Asp Gly Asp Leu Lys Glu Pro Thr Glu Arg Val Thr Arg Asp Leu Ser 
65                  70                  75                  80  


Ser Gly Ala Pro Arg Gly Arg Asn Leu Pro Ala Pro Asp Gln Pro Gln 
                85                  90                  95      


Pro Pro Leu Gln Arg Gly Thr Arg Leu Arg Leu Arg Gln Arg Arg Arg 
            100                 105                 110         


Arg Leu Leu Ile Lys Lys Met Pro Ala Ala Ala Thr Ile Pro Ala Asn 
        115                 120                 125             


Ser Ser Asp Ala Pro Phe Ile Arg Pro Gly Pro Gly Thr Leu Asp Gly 
    130                 135                 140                 


Arg Trp Val Ser Leu His Arg Ser Gln Gln Glu Arg Lys Arg Val Met 
145                 150                 155                 160 


Gln Glu Ala Cys Ala Lys Tyr Arg Ala Ser Ser Ser Arg Arg Ala Val 
                165                 170                 175     


Thr Pro Arg His Val Ser Arg Ile Phe Val Glu Asp Arg His Arg Val 
            180                 185                 190         


Leu Tyr Cys Glu Val Pro Lys Ala Gly Cys Ser Asn Trp Lys Arg Val 
        195                 200                 205             


Leu Met Val Leu Ala Gly Leu Ala Ser Ser Thr Ala Asp Ile Gln His 
    210                 215                 220                 


Asn Thr Val His Tyr Gly Ser Ala Leu Lys Arg Leu Asp Thr Phe Asp 
225                 230                 235                 240 


Arg Gln Gly Ile Leu His Arg Leu Ser Thr Tyr Thr Lys Met Leu Phe 
                245                 250                 255     


Val Arg Glu Pro Phe Glu Arg Leu Val Ser Ala Phe Arg Asp Lys Phe 
            260                 265                 270         


Glu His Pro Asn Ser Tyr Tyr His Pro Val Phe Gly Lys Ala Ile Leu 
        275                 280                 285             


Ala Arg Tyr Arg Ala Asn Ala Ser Arg Glu Ala Leu Arg Thr Gly Ser 
    290                 295                 300                 


Gly Val Arg Phe Pro Glu Phe Val Gln Tyr Leu Leu Asp Val His Arg 
305                 310                 315                 320 


Pro Val Gly Met Asp Ile His Trp Asp His Val Ser Arg Leu Cys Ser 
                325                 330                 335     


Pro Cys Leu Ile Asp Tyr Asp Phe Val Gly Lys Phe Glu Ser Met Glu 
            340                 345                 350         


Asp Asp Ala Asn Phe Phe Leu Ser Leu Ile Arg Ala Pro Arg Asn Leu 
        355                 360                 365             


Thr Phe Pro Arg Phe Lys Asp Arg His Ser Gln Glu Ala Arg Thr Thr 
    370                 375                 380                 


Ala Arg Ile Ala His Gln Tyr Phe Ala Gln Leu Ser Ala Leu Gln Arg 
385                 390                 395                 400 


Gln Arg Thr Tyr Asp Phe Tyr Tyr Met Asp Tyr Leu Met Phe Asn Tyr 
                405                 410                 415     


Ser Lys Pro Phe Ala Asp Leu Tyr 
            420                 


<210>  2915
<211>  53
<212>  PRT
<213>  Homo Sapiens

<400>  2915

Glu Asp Val Glu Val Gly Arg Cys Val Arg Arg Phe Ala Gly Val Gln 
1               5                   10                  15      


Cys Val Trp Ser Tyr Glu Asp Lys Arg Val Arg Lys Pro Leu Leu Cys 
            20                  25                  30          


Asn Glu Leu Lys Arg Cys Leu Ser Pro Asn Gly Lys Leu Ser Leu Cys 
        35                  40                  45              


Ser Ser Asp Gly Leu 
    50              


<210>  2916
<211>  802
<212>  PRT
<213>  Homo Sapiens

<400>  2916

Met Ala Ala Arg Gly Arg Arg Ala Trp Leu Ser Val Leu Leu Gly Leu 
1               5                   10                  15      


Val Leu Gly Phe Val Leu Ala Ser Arg Leu Val Leu Pro Arg Ala Ser 
            20                  25                  30          


Glu Leu Lys Arg Ala Gly Pro Arg Arg Arg Ala Ser Pro Glu Gly Cys 
        35                  40                  45              


Arg Ser Gly Gln Ala Ala Ala Ser Gln Ala Gly Gly Ala Arg Gly Asp 
    50                  55                  60                  


Ala Arg Gly Ala Gln Leu Trp Pro Pro Gly Ser Asp Pro Asp Gly Gly 
65                  70                  75                  80  


Pro Arg Asp Arg Asn Phe Leu Phe Val Gly Val Met Thr Ala Gln Lys 
                85                  90                  95      


Tyr Leu Gln Thr Arg Ala Val Ala Ala Tyr Arg Thr Trp Ser Lys Thr 
            100                 105                 110         


Ile Pro Gly Lys Val Gln Phe Phe Ser Ser Glu Gly Ser Asp Thr Ser 
        115                 120                 125             


Val Pro Ile Pro Val Val Pro Leu Arg Gly Val Asp Asp Ser Tyr Pro 
    130                 135                 140                 


Pro Gln Lys Lys Ser Phe Met Met Leu Lys Tyr Met His Asp His Tyr 
145                 150                 155                 160 


Leu Asp Lys Tyr Glu Trp Phe Met Arg Ala Asp Asp Asp Val Tyr Ile 
                165                 170                 175     


Lys Gly Asp Arg Leu Glu Asn Phe Leu Arg Ser Leu Asn Ser Ser Glu 
            180                 185                 190         


Pro Leu Phe Leu Gly Gln Thr Gly Leu Gly Thr Thr Glu Glu Met Gly 
        195                 200                 205             


Lys Leu Ala Leu Glu Pro Gly Glu Asn Phe Cys Met Gly Gly Pro Gly 
    210                 215                 220                 


Val Ile Met Ser Arg Glu Val Leu Arg Arg Met Val Pro His Ile Gly 
225                 230                 235                 240 


Lys Cys Leu Arg Glu Met Tyr Thr Thr His Glu Asp Val Glu Val Gly 
                245                 250                 255     


Arg Cys Val Arg Arg Phe Ala Gly Val Gln Cys Val Trp Ser Tyr Glu 
            260                 265                 270         


Met Gln Gln Leu Phe Tyr Glu Asn Tyr Glu Gln Asn Lys Lys Gly Tyr 
        275                 280                 285             


Ile Arg Asp Leu His Asn Ser Lys Ile His Gln Ala Ile Thr Leu His 
    290                 295                 300                 


Pro Asn Lys Asn Pro Pro Tyr Gln Tyr Arg Leu His Ser Tyr Met Leu 
305                 310                 315                 320 


Ser Arg Lys Ile Ser Glu Leu Arg His Arg Thr Ile Gln Leu His Arg 
                325                 330                 335     


Glu Ile Val Leu Met Ser Lys Tyr Ser Asn Thr Glu Ile His Lys Glu 
            340                 345                 350         


Asp Leu Gln Leu Gly Ile Pro Pro Ser Phe Met Arg Phe Gln Pro Arg 
        355                 360                 365             


Gln Arg Glu Glu Ile Leu Glu Trp Glu Phe Leu Thr Gly Lys Tyr Leu 
    370                 375                 380                 


Tyr Ser Ala Val Asp Gly Gln Pro Pro Arg Arg Gly Met Asp Ser Ala 
385                 390                 395                 400 


Gln Arg Glu Ala Leu Asp Asp Ile Val Met Gln Val Met Glu Met Ile 
                405                 410                 415     


Asn Ala Asn Ala Lys Thr Arg Gly Arg Ile Ile Asp Phe Lys Glu Ile 
            420                 425                 430         


Gln Tyr Gly Tyr Arg Arg Val Asn Pro Met Tyr Gly Ala Glu Tyr Ile 
        435                 440                 445             


Leu Asp Leu Leu Leu Leu Tyr Lys Lys His Lys Gly Lys Lys Met Thr 
    450                 455                 460                 


Val Pro Val Arg Arg His Ala Tyr Leu Gln Gln Thr Phe Ser Lys Ile 
465                 470                 475                 480 


Gln Phe Val Glu His Glu Glu Leu Asp Ala Gln Glu Leu Ala Lys Arg 
                485                 490                 495     


Ile Asn Gln Glu Ser Gly Ser Leu Ser Phe Leu Ser Asn Ser Leu Lys 
            500                 505                 510         


Lys Leu Val Pro Phe Gln Leu Pro Gly Ser Lys Ser Glu His Lys Glu 
        515                 520                 525             


Pro Lys Asp Lys Lys Ile Asn Ile Leu Ile Pro Leu Ser Gly Arg Phe 
    530                 535                 540                 


Asp Met Phe Val Arg Phe Met Gly Asn Phe Glu Lys Thr Cys Leu Ile 
545                 550                 555                 560 


Pro Asn Gln Asn Val Lys Leu Val Val Leu Leu Phe Asn Ser Asp Ser 
                565                 570                 575     


Asn Pro Asp Lys Ala Lys Gln Val Glu Leu Met Arg Asp Tyr Arg Ile 
            580                 585                 590         


Lys Tyr Pro Lys Ala Asp Met Gln Ile Leu Pro Val Ser Gly Glu Phe 
        595                 600                 605             


Ser Arg Ala Leu Ala Leu Glu Val Gly Ser Ser Gln Phe Asn Asn Glu 
    610                 615                 620                 


Ser Leu Leu Phe Phe Cys Asp Val Asp Leu Val Phe Thr Thr Glu Phe 
625                 630                 635                 640 


Leu Gln Arg Cys Arg Ala Asn Thr Val Leu Gly Gln Gln Ile Tyr Phe 
                645                 650                 655     


Pro Ile Ile Phe Ser Gln Tyr Asp Pro Lys Ile Val Tyr Ser Gly Lys 
            660                 665                 670         


Val Pro Ser Asp Asn His Phe Ala Phe Thr Gln Lys Thr Gly Phe Trp 
        675                 680                 685             


Arg Asn Tyr Gly Phe Gly Ile Thr Cys Ile Tyr Lys Gly Asp Leu Val 
    690                 695                 700                 


Arg Val Gly Gly Phe Asp Val Ser Ile Gln Gly Trp Gly Leu Glu Asp 
705                 710                 715                 720 


Val Asp Leu Phe Asn Lys Val Val Gln Ala Gly Leu Lys Thr Phe Arg 
                725                 730                 735     


Ser Gln Glu Val Gly Val Val His Val His His Pro Val Phe Cys Asp 
            740                 745                 750         


Pro Asn Leu Asp Pro Lys Gln Tyr Lys Met Cys Leu Gly Ser Lys Ala 
        755                 760                 765             


Ser Thr Tyr Gly Ser Thr Gln Gln Leu Ala Glu Met Trp Leu Glu Lys 
    770                 775                 780                 


Asn Asp Pro Ser Tyr Ser Lys Ser Ser Asn Asn Asn Gly Ser Val Arg 
785                 790                 795                 800 


Thr Ala 
        


<210>  2917
<211>  882
<212>  PRT
<213>  Homo Sapiens

<400>  2917

Met Ala Val Arg Ser Arg Arg Pro Trp Met Ser Val Ala Leu Gly Leu 
1               5                   10                  15      


Val Leu Gly Phe Thr Ala Ala Ser Trp Leu Ile Ala Pro Arg Val Ala 
            20                  25                  30          


Glu Leu Ser Glu Arg Lys Arg Arg Gly Ser Ser Leu Cys Ser Tyr Tyr 
        35                  40                  45              


Gly Arg Ser Ala Ala Gly Pro Arg Ala Gly Ala Gln Gln Pro Leu Pro 
    50                  55                  60                  


Gln Pro Gln Ser Arg Pro Arg Gln Glu Gln Ser Pro Pro Pro Ala Arg 
65                  70                  75                  80  


Gln Asp Leu Gln Gly Pro Pro Leu Pro Glu Ala Ala Pro Gly Ile Thr 
                85                  90                  95      


Ser Phe Arg Ser Ser Pro Trp Gln Gln Pro Pro Pro Leu Gln Gln Arg 
            100                 105                 110         


Arg Arg Gly Arg Glu Pro Glu Gly Ala Thr Gly Leu Pro Gly Ala Pro 
        115                 120                 125             


Ala Ala Glu Gly Glu Pro Glu Glu Glu Asp Gly Gly Ala Ala Gly Gln 
    130                 135                 140                 


Arg Arg Asp Gly Arg Pro Gly Ser Ser His Asn Gly Ser Gly Asp Gly 
145                 150                 155                 160 


Gly Ala Ala Ala Pro Ser Ala Arg Pro Arg Asp Phe Leu Tyr Val Gly 
                165                 170                 175     


Val Met Thr Ala Gln Lys Tyr Leu Gly Ser Arg Ala Leu Ala Ala Gln 
            180                 185                 190         


Arg Thr Trp Ala Arg Phe Ile Pro Gly Arg Val Glu Phe Phe Ser Ser 
        195                 200                 205             


Gln Gln Pro Pro Asn Ala Gly Gln Pro Pro Pro Pro Leu Pro Val Ile 
    210                 215                 220                 


Ala Leu Pro Gly Val Asp Asp Ser Tyr Pro Pro Gln Lys Lys Ser Phe 
225                 230                 235                 240 


Met Met Ile Lys Tyr Met His Asp His Tyr Leu Asp Lys Tyr Glu Trp 
                245                 250                 255     


Phe Met Arg Ala Asp Asp Asp Val Tyr Ile Lys Gly Asp Lys Leu Glu 
            260                 265                 270         


Glu Phe Leu Arg Ser Leu Asn Ser Ser Lys Pro Leu Tyr Leu Gly Gln 
        275                 280                 285             


Thr Gly Leu Gly Asn Ile Glu Glu Leu Gly Lys Leu Gly Leu Glu Pro 
    290                 295                 300                 


Gly Glu Asn Phe Cys Met Gly Gly Pro Gly Met Ile Phe Ser Arg Glu 
305                 310                 315                 320 


Val Leu Arg Arg Met Val Pro His Ile Gly Glu Cys Leu Arg Glu Met 
                325                 330                 335     


Tyr Thr Thr His Glu Asp Val Glu Val Gly Arg Cys Val Arg Arg Phe 
            340                 345                 350         


Gly Gly Thr Gln Cys Val Trp Ser Tyr Glu Met Gln Gln Leu Phe His 
        355                 360                 365             


Glu Asn Tyr Glu His Asn Arg Lys Gly Tyr Ile Gln Asp Leu His Asn 
    370                 375                 380                 


Ser Lys Ile His Ala Ala Ile Thr Leu His Pro Asn Lys Arg Pro Ala 
385                 390                 395                 400 


Tyr Gln Tyr Arg Leu His Asn Tyr Met Leu Ser Arg Lys Ile Ser Glu 
                405                 410                 415     


Leu Arg Tyr Arg Thr Ile Gln Leu His Arg Glu Ser Ala Leu Met Ser 
            420                 425                 430         


Lys Leu Ser Asn Thr Glu Val Ser Lys Glu Asp Gln Gln Leu Gly Val 
        435                 440                 445             


Ile Pro Ser Phe Asn His Phe Gln Pro Arg Glu Arg Asn Glu Val Ile 
    450                 455                 460                 


Glu Trp Glu Phe Leu Thr Gly Lys Leu Leu Tyr Ser Ala Ala Glu Asn 
465                 470                 475                 480 


Gln Pro Pro Arg Gln Ser Leu Ser Ser Ile Leu Arg Thr Ala Leu Asp 
                485                 490                 495     


Asp Thr Val Leu Gln Val Met Glu Met Ile Asn Glu Asn Ala Lys Ser 
            500                 505                 510         


Arg Gly Arg Leu Ile Asp Phe Lys Glu Ile Gln Tyr Gly Tyr Arg Arg 
        515                 520                 525             


Val Asn Pro Met His Gly Val Glu Tyr Ile Leu Asp Leu Leu Leu Leu 
    530                 535                 540                 


Tyr Lys Arg His Lys Gly Arg Lys Leu Thr Val Pro Val Arg Arg His 
545                 550                 555                 560 


Ala Tyr Leu Gln Gln Leu Phe Ser Lys Pro Phe Phe Arg Glu Thr Glu 
                565                 570                 575     


Glu Leu Asp Val Asn Ser Leu Val Glu Ser Ile Asn Ser Glu Thr Gln 
            580                 585                 590         


Ser Phe Ser Phe Ile Ser Asn Ser Leu Lys Ile Leu Ser Ser Phe Gln 
        595                 600                 605             


Gly Ala Lys Glu Met Gly Gly His Asn Glu Lys Lys Val His Ile Leu 
    610                 615                 620                 


Val Pro Leu Ile Gly Arg Tyr Asp Ile Phe Leu Arg Phe Met Glu Asn 
625                 630                 635                 640 


Phe Glu Asn Met Cys Leu Ile Pro Lys Gln Asn Val Lys Leu Val Ile 
                645                 650                 655     


Ile Leu Phe Ser Arg Asp Ser Gly Gln Asp Ser Ser Lys His Ile Glu 
            660                 665                 670         


Leu Ile Lys Gly Tyr Gln Asn Lys Tyr Pro Lys Ala Glu Met Thr Leu 
        675                 680                 685             


Ile Pro Met Lys Gly Glu Phe Ser Arg Gly Leu Gly Leu Glu Met Ala 
    690                 695                 700                 


Ser Ala Gln Phe Asp Asn Asp Thr Leu Leu Leu Phe Cys Asp Val Asp 
705                 710                 715                 720 


Leu Ile Phe Arg Glu Asp Phe Leu Gln Arg Cys Arg Asp Asn Thr Ile 
                725                 730                 735     


Gln Gly Gln Gln Val Tyr Tyr Pro Ile Ile Phe Ser Gln Tyr Asp Pro 
            740                 745                 750         


Lys Val Thr Asn Gly Gly Asn Pro Pro Thr Asp Asp Tyr Phe Ile Phe 
        755                 760                 765             


Ser Lys Lys Thr Gly Phe Trp Arg Asp Tyr Gly Tyr Gly Ile Thr Cys 
    770                 775                 780                 


Ile Tyr Lys Ser Asp Leu Leu Gly Ala Gly Gly Phe Asp Thr Ser Ile 
785                 790                 795                 800 


Gln Gly Trp Gly Leu Glu Asp Val Asp Leu Tyr Asn Lys Val Ile Leu 
                805                 810                 815     


Ser Gly Leu Arg Pro Phe Arg Ser Gln Glu Val Gly Val Val His Ile 
            820                 825                 830         


Phe His Pro Val His Cys Asp Pro Asn Leu Asp Pro Lys Gln Tyr Lys 
        835                 840                 845             


Met Cys Leu Gly Ser Lys Ala Ser Thr Phe Ala Ser Thr Met Gln Leu 
    850                 855                 860                 


Ala Glu Leu Trp Leu Glu Lys His Leu Gly Val Arg Tyr Asn Arg Thr 
865                 870                 875                 880 


Leu Ser 
        


<210>  2918
<211>  65
<212>  PRT
<213>  Homo Sapiens

<400>  2918

His Ile Leu Tyr Gly Lys Ile Ile His Leu Glu Lys Pro Phe Ala Val 
1               5                   10                  15      


Leu Val Lys His Thr Pro Gly Asp Gln Asp Cys Asp Glu Leu Gly Arg 
            20                  25                  30          


Glu Thr Gly Thr Arg Tyr Leu Val Thr Ala Leu Ile Lys Asp Lys Ile 
        35                  40                  45              


Leu Phe Lys Thr Arg Pro Lys Pro Ile Ile Thr Ser Val Pro Lys Lys 
    50                  55                  60                  


Val 
65  


<210>  2919
<211>  524
<212>  PRT
<213>  Homo Sapiens

<400>  2919

Met Lys Glu Pro Arg Ile Phe Pro Arg Glu Arg Pro Thr Pro Trp Thr 
1               5                   10                  15      


Arg Ala Pro Leu Pro Pro Arg Gly Arg Leu Asp Gly Ser Leu Gly Pro 
            20                  25                  30          


Gln Gly Gly Pro Val Leu Asn Thr Gly His Pro Leu Gly Val Asn Ser 
        35                  40                  45              


Asp Pro Phe Leu Met Ala Ala Gly Ser Leu Gly Gly Asn Leu Thr Pro 
    50                  55                  60                  


Phe Pro Arg Asn Pro Ser Pro Phe Pro Ala Ser Ser Gly Ser Leu Ala 
65                  70                  75                  80  


Ser Asn Pro Ala Pro Phe Pro Ala Gly Ala Arg Asp Pro Ser Met Ala 
                85                  90                  95      


Ser Phe Pro Arg Gly Met Asn Pro Thr Gly Thr Gly Ala Val Ser Phe 
            100                 105                 110         


Pro Arg Pro Gly Gly Leu Leu Gly Pro Gly Pro Gly Pro Gly Pro Thr 
        115                 120                 125             


Leu Asn Pro Arg Thr Gly Ala Leu Pro Gly Pro Gly Pro Leu Ser Asn 
    130                 135                 140                 


Pro Arg Leu Gly Gly Leu Pro Gly Pro Gly Pro Met Ser Asn Pro Arg 
145                 150                 155                 160 


Ala Gly Gly Leu Leu Gly Ala Gly Pro Asp Pro Arg Gly Gly Gly Pro 
                165                 170                 175     


Met Gly Pro Gly Ser Gly Pro Asn Leu Arg Ala Gly Val Leu Leu Thr 
            180                 185                 190         


Ser Gly Asn Gly Pro Pro Asn Pro Arg Pro Val Gly Leu Gly Pro Gly 
        195                 200                 205             


Pro Asn Pro Asn Leu Arg Ser Gly Phe Leu Gly Thr Asn Pro Ala Pro 
    210                 215                 220                 


Arg Ser Gly Val Phe Pro Gly Pro Gly Leu Gly Pro Asn Pro Arg Pro 
225                 230                 235                 240 


Ser Gly Leu Gly Pro Gly Pro Asn Leu Asp Ala Arg Ala Gly Gly Leu 
                245                 250                 255     


Leu Gly Thr Gly Ser Gly Leu Asn Leu Arg Met Ala Gly Pro Gln Gly 
            260                 265                 270         


Leu Asp Leu Ala Pro Ile Leu Arg Ala Ala Gly Leu Leu Gly Ala Asn 
        275                 280                 285             


Ser Ala Ser Phe Ser Gln Ala Ser Gly Asn Met Gly Thr Ser Pro Ser 
    290                 295                 300                 


Ser Met Ala Arg Val Pro Gly Pro Met Gly Pro Asn Ser Gly Pro Ser 
305                 310                 315                 320 


Ser Arg Gly Ile Gly Leu Pro Gly Pro Asn Pro Ser Pro Met Ser Arg 
                325                 330                 335     


Ala Pro Gly Pro Ile Gly Pro Asn Ser Ala His Phe Ser Arg Pro Val 
            340                 345                 350         


Gly Pro Met Gly Val Asn Ala Asn Pro Phe Pro Arg Gly Ala Gly Ser 
        355                 360                 365             


Ser Ala Phe Ser Gln Ser Ser Gly Thr Leu Ala Ser Asn Pro Ala Thr 
    370                 375                 380                 


Phe Gln Arg Ser Ala Gly Leu Gln Gly Ser Asn Pro Thr Ile Phe Pro 
385                 390                 395                 400 


Arg Ala Ser Gly Pro Leu Gly Pro Asn Pro Ala Asn Phe Pro Arg Ala 
                405                 410                 415     


Thr Gly Leu Gln Gly Pro Ser Pro Thr Thr Phe Pro Arg Ser Thr Gly 
            420                 425                 430         


Pro Leu Gly Pro Gly Gln Val Thr Phe Pro Arg Pro Ala Ala Gly His 
        435                 440                 445             


Leu Gly Pro Ser Pro Ala Gly Pro Val Gly Ile Asn Pro Ala Pro Phe 
    450                 455                 460                 


Thr Arg Pro Thr Gly Thr Leu Gly Leu Asn Pro Ala Ser Phe Pro Arg 
465                 470                 475                 480 


Met Asn Gly Pro Ala Gly Lys Ser Phe Val Pro Phe Pro Arg Val Gly 
                485                 490                 495     


Ser Leu Pro Gly Thr Asn Pro Ala Ala Phe Pro Arg Pro Gly Gly Pro 
            500                 505                 510         


Met Ala Ala Met Tyr Pro Asn Gly Met Leu Pro Pro 
        515                 520                 


<210>  2920
<211>  12
<212>  PRT
<213>  Homo Sapiens

<400>  2920

Met Val Gln Ile Val Ile Ser Arg Glu Ser Leu Cys 
1               5                   10          


<210>  2921
<211>  12
<212>  PRT
<213>  Homo Sapiens

<400>  2921

Met Val Gln Ile Val Ile Ser Arg Glu Ser Leu Cys 
1               5                   10          


<210>  2922
<211>  121
<212>  PRT
<213>  Homo Sapiens

<400>  2922

Met Val Gln Ile Val Ile Ser Ser Ala Arg Ala Gly Gly Leu Ala Glu 
1               5                   10                  15      


Trp Val Leu Met Glu Leu Gln Gly Glu Ile Glu Ala Arg Tyr Ser Thr 
            20                  25                  30          


Gly Leu Ala Gly Asn Leu Leu Gly Asp Leu His Tyr Thr Thr Glu Gly 
        35                  40                  45              


Ile Pro Val Leu Ile Val Gly His His Ile Leu Tyr Gly Lys Ile Ile 
    50                  55                  60                  


His Leu Glu Lys Pro Phe Ala Val Leu Val Lys His Thr Pro Gly Asp 
65                  70                  75                  80  


Gln Asp Cys Asp Glu Leu Gly Arg Glu Thr Gly Thr Arg Tyr Leu Val 
                85                  90                  95      


Thr Ala Leu Ile Lys Asp Lys Ile Leu Phe Lys Thr Arg Pro Lys Pro 
            100                 105                 110         


Ile Ile Thr Ser Val Pro Lys Lys Val 
        115                 120     


<210>  2923
<211>  121
<212>  PRT
<213>  Homo Sapiens

<400>  2923

Met Val Gln Ile Val Ile Ser Ser Ala Arg Ala Gly Gly Leu Ala Glu 
1               5                   10                  15      


Trp Val Leu Met Glu Leu Gln Gly Glu Ile Glu Ala Arg Tyr Ser Thr 
            20                  25                  30          


Gly Leu Ala Gly Asn Leu Leu Gly Asp Leu His Tyr Thr Thr Glu Gly 
        35                  40                  45              


Ile Pro Val Leu Ile Val Gly His His Ile Leu Tyr Gly Lys Ile Ile 
    50                  55                  60                  


His Leu Glu Lys Pro Phe Ala Val Leu Val Lys His Thr Pro Gly Asp 
65                  70                  75                  80  


Gln Asp Cys Asp Glu Leu Gly Arg Glu Thr Gly Thr Arg Tyr Leu Val 
                85                  90                  95      


Thr Ala Leu Ile Lys Asp Lys Ile Leu Phe Lys Thr Arg Pro Lys Pro 
            100                 105                 110         


Ile Ile Thr Ser Val Pro Lys Lys Val 
        115                 120     


<210>  2924
<211>  58
<212>  PRT
<213>  Homo Sapiens

<400>  2924

Met Val Gln Ile Val Ile Ser Ser Ala Arg Ala Gly Gly Leu Ala Glu 
1               5                   10                  15      


Trp Val Leu Met Glu Leu Gln Gly Glu Ile Glu Ala Arg Tyr Ser Thr 
            20                  25                  30          


Gly Leu Ala Gly Asn Leu Leu Gly Asp Leu His Tyr Thr Thr Glu Gly 
        35                  40                  45              


Tyr Ile Gly Leu Gln Val Pro Val His Met 
    50                  55              


<210>  2925
<211>  75
<212>  PRT
<213>  Homo Sapiens

<400>  2925

Met Val Gln Ile Val Ile Ser Ser Ala Arg Ala Gly Gly Leu Ala Glu 
1               5                   10                  15      


Trp Val Leu Met Glu Leu Gln Gly Glu Ile Glu Ala Arg Tyr Ser Thr 
            20                  25                  30          


Gly Leu Ala Gly Asn Leu Leu Gly Asp Leu His Tyr Thr Thr Glu Leu 
        35                  40                  45              


His Gln Ala His Trp Leu Gln Ile Gln His Leu Ser Arg Leu Val Leu 
    50                  55                  60                  


Val Thr Gln Val Trp Leu Leu Phe Gln Glu Gly 
65                  70                  75  


<210>  2926
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  2926

Met Val Gln Ile Val Ile Ser Ser Ala Arg Ala Gly Gly Leu Ala Glu 
1               5                   10                  15      


Trp Val Leu Met Glu Leu Gln Gly Glu Ile Glu Ala Arg Tyr Ser Thr 
            20                  25                  30          


Gly Leu Ala Gly Asn Leu Leu Gly Asp Leu His Tyr Thr Thr Glu Val 
        35                  40                  45              


Arg Gly Leu Phe Phe Pro Cys Leu Met Pro Gln Glu Ser Lys Leu His 
    50                  55                  60                  


Gln Gly Gly Ala Pro Arg Thr Gln Ser Glu Asp Cys Leu Arg Phe Val 
65                  70                  75                  80  


Ile Gln Gly Leu Ala Asn Leu Arg Cys Ser Leu Leu Val Leu Pro Leu 
                85                  90                  95      


Pro Leu Gln 
            


<210>  2927
<211>  144
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2927

Xaa Ala Val Leu Ala Ala Ala Ala Thr Ala Ala Gly Gly Ser Val Val 
1               5                   10                  15      


Ala Arg Trp Pro Arg Gly Ala Ala Leu Gly Gly Arg His Cys Ser Ala 
            20                  25                  30          


Arg Ala Gly Gly Leu Ala Glu Trp Val Leu Met Glu Leu Gln Gly Glu 
        35                  40                  45              


Ile Glu Ala Arg Tyr Ser Thr Gly Leu Ala Gly Asn Leu Leu Gly Asp 
    50                  55                  60                  


Leu His Tyr Thr Thr Glu Gly Ile Pro Val Leu Ile Val Gly His His 
65                  70                  75                  80  


Ile Leu Tyr Gly Lys Ile Ile His Leu Glu Lys Pro Phe Ala Val Leu 
                85                  90                  95      


Val Lys His Thr Pro Gly Asp Gln Asp Cys Asp Glu Leu Gly Arg Glu 
            100                 105                 110         


Thr Gly Thr Arg Tyr Leu Val Thr Ala Leu Ile Lys Asp Lys Ile Leu 
        115                 120                 125             


Phe Lys Thr Arg Pro Lys Pro Ile Ile Thr Ser Val Pro Lys Lys Val 
    130                 135                 140                 


<210>  2928
<211>  104
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2928

Xaa Ser Ala Arg Gly Gly Gly Asp Gly Gly Gly Arg Phe Gly Cys Arg 
1               5                   10                  15      


Pro Leu Ala Ala Arg Arg Arg Ala Arg Arg Pro Pro Leu Gln Gly Ile 
            20                  25                  30          


Pro Val Leu Ile Val Gly His His Ile Leu Tyr Gly Lys Ile Ile His 
        35                  40                  45              


Leu Glu Lys Pro Phe Ala Val Leu Val Lys His Thr Pro Gly Asp Gln 
    50                  55                  60                  


Asp Cys Asp Glu Leu Gly Arg Glu Thr Gly Thr Arg Tyr Leu Val Thr 
65                  70                  75                  80  


Ala Leu Ile Lys Asp Lys Ile Leu Phe Lys Thr Arg Pro Lys Pro Ile 
                85                  90                  95      


Ile Thr Ser Val Pro Lys Lys Val 
            100                 


<210>  2929
<211>  1184
<212>  PRT
<213>  Homo Sapiens

<400>  2929

Met Val Gly Thr Lys Ala Trp Val Phe Ser Phe Leu Val Leu Glu Val 
1               5                   10                  15      


Thr Ser Val Leu Gly Arg Gln Thr Met Leu Thr Gln Ser Val Arg Arg 
            20                  25                  30          


Val Gln Pro Gly Lys Lys Asn Pro Ser Ile Phe Ala Lys Pro Ala Asp 
        35                  40                  45              


Thr Leu Glu Ser Pro Gly Glu Trp Thr Thr Trp Phe Asn Ile Asp Tyr 
    50                  55                  60                  


Pro Gly Gly Lys Gly Asp Tyr Glu Arg Leu Asp Ala Ile Arg Phe Tyr 
65                  70                  75                  80  


Tyr Gly Asp Arg Val Cys Ala Arg Pro Leu Arg Leu Glu Ala Arg Thr 
                85                  90                  95      


Thr Asp Trp Thr Pro Ala Gly Ser Thr Gly Gln Val Val His Gly Ser 
            100                 105                 110         


Pro Arg Glu Gly Phe Trp Cys Leu Asn Arg Glu Gln Arg Pro Gly Gln 
        115                 120                 125             


Asn Cys Ser Asn Tyr Thr Val Arg Phe Leu Cys Pro Pro Gly Ser Leu 
    130                 135                 140                 


Arg Arg Asp Thr Glu Arg Ile Trp Ser Pro Trp Ser Pro Trp Ser Lys 
145                 150                 155                 160 


Cys Ser Ala Ala Cys Gly Gln Thr Gly Val Gln Thr Arg Thr Arg Ile 
                165                 170                 175     


Cys Leu Ala Glu Met Val Ser Leu Cys Ser Glu Ala Ser Glu Glu Gly 
            180                 185                 190         


Gln His Cys Met Gly Gln Asp Cys Thr Ala Cys Asp Leu Thr Cys Pro 
        195                 200                 205             


Met Gly Gln Val Asn Ala Asp Cys Asp Ala Cys Met Cys Gln Asp Phe 
    210                 215                 220                 


Met Leu His Gly Ala Val Ser Leu Pro Gly Gly Ala Pro Ala Ser Gly 
225                 230                 235                 240 


Ala Ala Ile Tyr Leu Leu Thr Lys Thr Pro Lys Leu Leu Thr Gln Thr 
                245                 250                 255     


Asp Ser Asp Gly Arg Phe Arg Ile Pro Gly Leu Cys Pro Asp Gly Lys 
            260                 265                 270         


Ser Ile Leu Lys Ile Thr Lys Val Lys Phe Ala Pro Ile Val Leu Thr 
        275                 280                 285             


Met Pro Lys Thr Ser Leu Lys Ala Ala Thr Ile Lys Ala Glu Phe Val 
    290                 295                 300                 


Arg Ala Glu Thr Pro Tyr Met Val Met Asn Pro Glu Thr Lys Ala Arg 
305                 310                 315                 320 


Arg Ala Gly Gln Ser Val Ser Leu Cys Cys Lys Ala Thr Gly Lys Pro 
                325                 330                 335     


Arg Pro Asp Lys Tyr Phe Trp Tyr His Asn Asp Thr Leu Leu Asp Pro 
            340                 345                 350         


Ser Leu Tyr Lys His Glu Ser Lys Leu Val Leu Arg Lys Leu Gln Gln 
        355                 360                 365             


His Gln Ala Gly Glu Tyr Phe Cys Lys Ala Gln Ser Asp Ala Gly Ala 
    370                 375                 380                 


Val Lys Ser Lys Val Ala Gln Leu Ile Val Ile Ala Ser Asp Glu Thr 
385                 390                 395                 400 


Pro Cys Asn Pro Val Pro Glu Ser Tyr Leu Ile Arg Leu Pro His Asp 
                405                 410                 415     


Cys Phe Gln Asn Ala Thr Asn Ser Phe Tyr Tyr Asp Val Gly Arg Cys 
            420                 425                 430         


Pro Val Lys Thr Cys Ala Gly Gln Gln Asp Asn Gly Ile Arg Cys Arg 
        435                 440                 445             


Asp Ala Val Gln Asn Cys Cys Gly Ile Ser Lys Thr Glu Glu Arg Glu 
    450                 455                 460                 


Ile Gln Cys Ser Gly Tyr Thr Leu Pro Thr Lys Val Ala Lys Glu Cys 
465                 470                 475                 480 


Ser Cys Gln Arg Cys Thr Glu Thr Arg Ser Ile Val Arg Gly Arg Val 
                485                 490                 495     


Ser Ala Ala Asp Asn Gly Glu Pro Met Arg Phe Gly His Val Tyr Met 
            500                 505                 510         


Gly Asn Ser Arg Val Ser Met Thr Gly Tyr Lys Gly Thr Phe Thr Leu 
        515                 520                 525             


His Val Pro Gln Asp Thr Glu Arg Leu Val Leu Thr Phe Val Asp Arg 
    530                 535                 540                 


Leu Gln Lys Phe Val Asn Thr Thr Lys Val Leu Pro Phe Asn Lys Lys 
545                 550                 555                 560 


Gly Ser Ala Val Phe His Glu Ile Lys Met Leu Arg Arg Lys Lys Pro 
                565                 570                 575     


Ile Thr Leu Glu Ala Met Glu Thr Asn Ile Ile Pro Leu Gly Glu Val 
            580                 585                 590         


Val Gly Glu Asp Pro Met Ala Glu Leu Glu Ile Pro Ser Arg Ser Phe 
        595                 600                 605             


Tyr Arg Gln Asn Gly Glu Pro Tyr Ile Gly Lys Val Lys Ala Ser Val 
    610                 615                 620                 


Thr Phe Leu Asp Pro Arg Asn Ile Ser Thr Ala Thr Ala Ala Gln Thr 
625                 630                 635                 640 


Asp Leu Asn Phe Ile Asn Asp Glu Gly Asp Thr Phe Pro Leu Arg Thr 
                645                 650                 655     


Tyr Gly Met Phe Ser Val Asp Phe Arg Asp Glu Val Thr Ser Glu Pro 
            660                 665                 670         


Leu Asn Ala Gly Lys Val Lys Val His Leu Asp Ser Thr Gln Val Lys 
        675                 680                 685             


Met Pro Glu His Ile Ser Thr Val Lys Leu Trp Ser Leu Asn Pro Asp 
    690                 695                 700                 


Thr Gly Leu Trp Glu Glu Glu Gly Asp Phe Lys Phe Glu Asn Gln Arg 
705                 710                 715                 720 


Arg Asn Lys Arg Glu Asp Arg Thr Phe Leu Val Gly Asn Leu Glu Ile 
                725                 730                 735     


Arg Glu Arg Arg Leu Phe Asn Leu Asp Val Pro Glu Ser Arg Arg Cys 
            740                 745                 750         


Phe Val Lys Val Arg Ala Tyr Arg Ser Glu Arg Phe Leu Pro Ser Glu 
        755                 760                 765             


Gln Ile Gln Gly Val Val Ile Ser Val Ile Asn Leu Glu Pro Arg Thr 
    770                 775                 780                 


Gly Phe Leu Ser Asn Pro Arg Ala Trp Gly Arg Phe Asp Ser Val Ile 
785                 790                 795                 800 


Thr Gly Pro Asn Gly Ala Cys Val Pro Ala Phe Cys Asp Asp Gln Ser 
                805                 810                 815     


Pro Asp Ala Tyr Ser Ala Tyr Val Leu Ala Ser Leu Ala Gly Glu Glu 
            820                 825                 830         


Leu Gln Ala Val Glu Ser Ser Pro Lys Phe Asn Pro Asn Ala Ile Gly 
        835                 840                 845             


Val Pro Gln Pro Tyr Leu Asn Lys Leu Asn Tyr Arg Arg Thr Asp His 
    850                 855                 860                 


Glu Asp Pro Arg Val Lys Lys Thr Ala Phe Gln Ile Ser Met Ala Lys 
865                 870                 875                 880 


Pro Arg Pro Asn Ser Ala Glu Glu Ser Asn Gly Pro Ile Tyr Ala Phe 
                885                 890                 895     


Glu Asn Leu Arg Ala Cys Glu Glu Ala Pro Pro Ser Ala Ala His Phe 
            900                 905                 910         


Arg Phe Tyr Gln Ile Glu Gly Asp Arg Tyr Asp Tyr Asn Thr Val Pro 
        915                 920                 925             


Phe Asn Glu Asp Asp Pro Met Ser Trp Thr Glu Asp Tyr Leu Ala Trp 
    930                 935                 940                 


Trp Pro Lys Pro Met Glu Phe Arg Ala Cys Tyr Ile Lys Val Lys Ile 
945                 950                 955                 960 


Val Gly Pro Leu Glu Val Asn Val Arg Ser Arg Asn Met Gly Gly Thr 
                965                 970                 975     


His Arg Gln Thr Val Gly Lys Leu Tyr Gly Ile Arg Asp Val Arg Ser 
            980                 985                 990         


Thr Arg Asp Arg Asp Gln Pro Asn  Val Ser Ala Ala Cys  Leu Glu Phe 
        995                 1000                 1005             


Lys Cys  Ser Gly Met Leu Tyr  Asp Gln Asp Arg Val  Asp Arg Thr 
    1010                 1015                 1020             


Leu Val  Lys Val Ile Pro Gln  Gly Ser Cys Arg Arg  Ala Ser Val 
    1025                 1030                 1035             


Asn Pro  Met Leu His Glu Tyr  Leu Val Asn His Leu  Pro Leu Ala 
    1040                 1045                 1050             


Val Asn  Asn Asp Thr Ser Glu  Tyr Thr Met Leu Ala  Pro Leu Asp 
    1055                 1060                 1065             


Pro Leu  Gly His Asn Tyr Gly  Ile Tyr Thr Val Thr  Asp Gln Asp 
    1070                 1075                 1080             


Pro Arg  Thr Ala Lys Glu Ile  Ala Leu Gly Arg Cys  Phe Asp Gly 
    1085                 1090                 1095             


Thr Ser  Asp Gly Ser Ser Arg  Ile Met Lys Ser Asn  Val Gly Val 
    1100                 1105                 1110             


Ala Leu  Thr Phe Asn Cys Val  Glu Arg Gln Val Gly  Arg Gln Ser 
    1115                 1120                 1125             


Ala Phe  Gln Tyr Leu Gln Ser  Thr Pro Ala Gln Ser  Pro Ala Ala 
    1130                 1135                 1140             


Gly Thr  Val Gln Gly Arg Val  Pro Ser Arg Arg Gln  Gln Arg Ala 
    1145                 1150                 1155             


Ser Arg  Gly Gly Gln Arg Gln  Gly Gly Val Val Ala  Ser Leu Arg 
    1160                 1165                 1170             


Phe Pro  Arg Val Ala Gln Gln  Pro Leu Ile Asn 
    1175                 1180                 


<210>  2930
<211>  1162
<212>  PRT
<213>  Homo Sapiens

<400>  2930

Met Ala Ser Leu Leu Pro Leu Leu Cys Leu Cys Val Val Ala Ala His 
1               5                   10                  15      


Leu Ala Gly Ala Arg Asp Ala Thr Pro Thr Glu Glu Pro Met Ala Thr 
            20                  25                  30          


Ala Leu Gly Leu Glu Arg Arg Ser Val Tyr Thr Gly Gln Pro Ser Pro 
        35                  40                  45              


Ala Leu Glu Asp Trp Glu Ala Arg Ala Val Pro Ala Glu Ala Ser Glu 
    50                  55                  60                  


Trp Thr Ser Trp Phe Asn Val Asp His Pro Gly Gly Asp Gly Asp Phe 
65                  70                  75                  80  


Glu Ser Leu Ala Ala Ile Arg Phe Tyr Tyr Gly Pro Ala Arg Val Cys 
                85                  90                  95      


Pro Arg Pro Leu Ala Leu Glu Ala Arg Thr Thr Asp Trp Ala Leu Pro 
            100                 105                 110         


Ser Ala Val Gly Glu Arg Val His Leu Asn Pro Thr Arg Gly Phe Trp 
        115                 120                 125             


Cys Leu Asn Arg Glu Gln Pro Arg Gly Arg Arg Cys Ser Asn Tyr His 
    130                 135                 140                 


Val Arg Phe Arg Cys Pro Leu Glu Ala Ser Trp Gly Ala Trp Gly Pro 
145                 150                 155                 160 


Trp Gly Pro Cys Ser Gly Ser Cys Gly Pro Gly Arg Arg Leu Arg Arg 
                165                 170                 175     


Arg His Cys Pro Ser Pro Ala Gly Asp Ala Cys Pro Gly Arg Pro Leu 
            180                 185                 190         


Glu Ala Gln Lys Cys Val Arg Pro Arg Cys Pro Gly Cys Ser Leu Asp 
        195                 200                 205             


Thr Cys Glu Cys Pro Asp His Ile Leu Leu Gly Ser Val Val Thr Pro 
    210                 215                 220                 


Ser Gly Gln Pro Leu Leu Gly Ala Arg Val Ser Leu Arg Asp Gln Pro 
225                 230                 235                 240 


Gly Thr Val Ala Thr Ser Asp Ala His Gly Thr Phe Arg Val Pro Gly 
                245                 250                 255     


Val Cys Ala Asp Ser Arg Ala Asn Ile Arg Ala Gln Met Asp Gly Phe 
            260                 265                 270         


Ser Ala Gly Glu Ala Gln Ala Gln Ala Asn Gly Ser Ile Ser Val Val 
        275                 280                 285             


Thr Ile Ile Leu Asp Lys Leu Glu Lys Pro Tyr Leu Val Lys His Pro 
    290                 295                 300                 


Glu Ser Arg Val Arg Glu Ala Gly Gln Asn Val Thr Phe Cys Cys Lys 
305                 310                 315                 320 


Ala Ser Gly Thr Pro Met Pro Lys Lys Tyr Ser Trp Phe His Asn Gly 
                325                 330                 335     


Thr Leu Leu Asp Arg Arg Ala His Gly Tyr Gly Ala His Leu Glu Leu 
            340                 345                 350         


Arg Gly Leu Arg Pro Asp Gln Ala Gly Ile Tyr His Cys Lys Ala Trp 
        355                 360                 365             


Asn Glu Ala Gly Ala Val Arg Ser Gly Thr Ala Arg Leu Thr Val Leu 
    370                 375                 380                 


Ala Pro Gly Gln Pro Ala Cys Asp Pro Arg Pro Arg Glu Tyr Leu Ile 
385                 390                 395                 400 


Lys Leu Pro Glu Asp Cys Gly Gln Pro Gly Ser Gly Pro Ala Tyr Leu 
                405                 410                 415     


Asp Val Gly Leu Cys Pro Asp Thr Arg Cys Pro Ser Leu Ala Gly Ser 
            420                 425                 430         


Ser Pro Arg Cys Gly Asp Ala Ser Ser Arg Cys Cys Ser Val Arg Arg 
        435                 440                 445             


Leu Glu Arg Arg Glu Ile His Cys Pro Gly Tyr Val Leu Pro Val Lys 
    450                 455                 460                 


Val Val Ala Glu Cys Gly Cys Gln Lys Cys Leu Pro Pro Arg Gly Leu 
465                 470                 475                 480 


Val Arg Gly Arg Val Val Ala Ala Asp Ser Gly Glu Pro Leu Arg Phe 
                485                 490                 495     


Ala Arg Ile Leu Leu Gly Gln Glu Pro Ile Gly Phe Thr Ala Tyr Gln 
            500                 505                 510         


Gly Asp Phe Thr Ile Glu Val Pro Pro Ser Thr Gln Arg Leu Val Val 
        515                 520                 525             


Thr Phe Val Asp Pro Ser Gly Glu Phe Met Asp Ala Val Arg Val Leu 
    530                 535                 540                 


Pro Phe Asp Pro Arg Gly Ala Gly Val Tyr His Glu Val Lys Ala Met 
545                 550                 555                 560 


Arg Lys Lys Ala Pro Val Ile Leu His Thr Ser Gln Ser Asn Thr Ile 
                565                 570                 575     


Pro Leu Gly Glu Leu Glu Asp Glu Ala Pro Leu Gly Glu Leu Val Leu 
            580                 585                 590         


Pro Ser Gly Ala Phe Arg Arg Ala Asp Gly Lys Pro Tyr Ser Gly Pro 
        595                 600                 605             


Val Glu Ala Arg Val Thr Phe Val Asp Pro Arg Asp Leu Thr Ser Ala 
    610                 615                 620                 


Ala Ser Ala Pro Ser Asp Leu Arg Phe Val Asp Ser Asp Gly Glu Leu 
625                 630                 635                 640 


Ala Pro Leu Arg Thr Tyr Gly Met Phe Ser Val Asp Leu Arg Ala Pro 
                645                 650                 655     


Gly Ser Ala Glu Gln Leu Gln Val Gly Pro Val Ala Val Arg Val Ala 
            660                 665                 670         


Ala Ser Gln Ile His Met Pro Gly His Val Glu Ala Leu Lys Leu Trp 
        675                 680                 685             


Ser Leu Asn Pro Glu Thr Gly Leu Trp Glu Glu Glu Ser Gly Phe Arg 
    690                 695                 700                 


Arg Glu Gly Ser Ser Gly Pro Arg Val Arg Arg Glu Glu Arg Val Phe 
705                 710                 715                 720 


Leu Val Gly Asn Val Glu Ile Arg Glu Arg Arg Leu Phe Asn Leu Asp 
                725                 730                 735     


Val Pro Glu Arg Arg Arg Cys Phe Val Lys Val Arg Ala Tyr Ala Asn 
            740                 745                 750         


Asp Lys Phe Thr Pro Ser Glu Gln Val Glu Gly Val Val Val Thr Leu 
        755                 760                 765             


Val Asn Leu Glu Pro Ala Pro Gly Phe Ser Ala Asn Pro Arg Ala Trp 
    770                 775                 780                 


Gly Arg Phe Asp Ser Ala Val Thr Gly Pro Asn Gly Ala Cys Leu Pro 
785                 790                 795                 800 


Ala Phe Cys Asp Ala Asp Arg Pro Asp Ala Tyr Thr Ala Leu Val Thr 
                805                 810                 815     


Ala Thr Leu Gly Gly Glu Glu Leu Glu Pro Ala Pro Ser Leu Pro Arg 
            820                 825                 830         


Pro Leu Pro Ala Thr Val Gly Val Thr Gln Pro Tyr Leu Asp Arg Leu 
        835                 840                 845             


Gly Tyr Arg Arg Thr Asp His Asp Asp Pro Ala Phe Lys Arg Asn Gly 
    850                 855                 860                 


Phe Arg Ile Asn Leu Ala Lys Pro Arg Pro Gly Asp Pro Ala Glu Ala 
865                 870                 875                 880 


Asn Gly Pro Val Tyr Pro Trp Arg Ser Leu Arg Glu Cys Gln Gly Ala 
                885                 890                 895     


Pro Val Thr Ala Ser His Phe Arg Phe Ala Arg Val Glu Ala Asp Lys 
            900                 905                 910         


Tyr Glu Tyr Asn Val Val Pro Phe Arg Glu Gly Thr Pro Ala Ser Trp 
        915                 920                 925             


Thr Gly Asp Leu Leu Ala Trp Trp Pro Asn Pro Gln Glu Phe Arg Ala 
    930                 935                 940                 


Cys Phe Leu Lys Val Lys Ile Gln Gly Pro Gln Glu Tyr Met Val Arg 
945                 950                 955                 960 


Ser His Asn Ala Gly Gly Ser His Pro Arg Thr Arg Gly Gln Leu Tyr 
                965                 970                 975     


Gly Leu Arg Asp Ala Arg Ser Val Arg Asp Pro Glu Arg Pro Gly Thr 
            980                 985                 990         


Ser Ala Ala Cys Val Glu Phe Lys  Cys Ser Gly Met Leu  Phe Asp Gln 
        995                 1000                 1005             


Arg Gln  Val Asp Arg Thr Leu  Val Thr Ile Met Pro  Gln Gly Ser 
    1010                 1015                 1020             


Cys Arg  Arg Val Ala Val Asn  Gly Leu Leu Arg Asp  Tyr Leu Thr 
    1025                 1030                 1035             


Arg His  Pro Pro Pro Val Pro  Ala Glu Asp Pro Ala  Ala Phe Ser 
    1040                 1045                 1050             


Met Leu  Ala Pro Leu Asp Pro  Leu Gly His Asn Tyr  Gly Val Tyr 
    1055                 1060                 1065             


Thr Val  Thr Asp Gln Ser Pro  Arg Leu Ala Lys Glu  Ile Ala Ile 
    1070                 1075                 1080             


Gly Arg  Cys Phe Asp Gly Ser  Ser Asp Gly Phe Ser  Arg Glu Met 
    1085                 1090                 1095             


Lys Ala  Asp Ala Gly Thr Ala  Val Thr Phe Gln Cys  Arg Glu Pro 
    1100                 1105                 1110             


Pro Ala  Gly Arg Pro Ser Leu  Phe Gln Arg Leu Leu  Glu Ser Pro 
    1115                 1120                 1125             


Ala Thr  Ala Leu Gly Asp Ile  Arg Arg Glu Met Ser  Glu Ala Ala 
    1130                 1135                 1140             


Gln Ala  Gln Ala Arg Ala Ser  Gly Pro Leu Arg Thr  Arg Arg Gly 
    1145                 1150                 1155             


Arg Val  Arg Gln 
    1160         


<210>  2931
<211>  1156
<212>  PRT
<213>  Homo Sapiens

<400>  2931

Met Ala Ser Leu Leu Pro Leu Leu Cys Leu Cys Val Val Ala Ala His 
1               5                   10                  15      


Leu Ala Gly Ala Arg Asp Ala Thr Pro Thr Glu Glu Pro Met Ala Thr 
            20                  25                  30          


Ala Leu Gly Leu Glu Arg Arg Ser Val Tyr Thr Gly Gln Pro Ser Pro 
        35                  40                  45              


Ala Leu Glu Asp Trp Glu Glu Ala Ser Glu Trp Thr Ser Trp Phe Asn 
    50                  55                  60                  


Val Asp His Pro Gly Gly Asp Gly Asp Phe Glu Ser Leu Ala Ala Ile 
65                  70                  75                  80  


Arg Phe Tyr Tyr Gly Pro Ala Arg Val Cys Pro Arg Pro Leu Ala Leu 
                85                  90                  95      


Glu Ala Arg Thr Thr Asp Trp Ala Leu Pro Ser Ala Val Gly Glu Arg 
            100                 105                 110         


Val His Leu Asn Pro Thr Arg Gly Phe Trp Cys Leu Asn Arg Glu Gln 
        115                 120                 125             


Pro Arg Gly Arg Arg Cys Ser Asn Tyr His Val Arg Phe Arg Cys Pro 
    130                 135                 140                 


Leu Glu Ala Ser Trp Gly Ala Trp Gly Pro Trp Gly Pro Cys Ser Gly 
145                 150                 155                 160 


Ser Cys Gly Pro Gly Arg Arg Leu Arg Arg Arg His Cys Pro Ser Pro 
                165                 170                 175     


Ala Gly Asp Ala Cys Pro Gly Arg Pro Leu Glu Ala Gln Lys Cys Val 
            180                 185                 190         


Arg Pro Arg Cys Pro Gly Cys Ser Leu Asp Thr Cys Glu Cys Pro Asp 
        195                 200                 205             


His Ile Leu Leu Gly Ser Val Val Thr Pro Ser Gly Gln Pro Leu Leu 
    210                 215                 220                 


Gly Ala Arg Val Ser Leu Arg Asp Gln Pro Gly Thr Val Ala Thr Ser 
225                 230                 235                 240 


Asp Ala His Gly Thr Phe Arg Val Pro Gly Val Cys Ala Asp Ser Arg 
                245                 250                 255     


Ala Asn Ile Arg Ala Gln Met Asp Gly Phe Ser Ala Gly Glu Ala Gln 
            260                 265                 270         


Ala Gln Ala Asn Gly Ser Ile Ser Val Val Thr Ile Ile Leu Asp Lys 
        275                 280                 285             


Leu Glu Lys Pro Tyr Leu Val Lys His Pro Glu Ser Arg Val Arg Glu 
    290                 295                 300                 


Ala Gly Gln Asn Val Thr Phe Cys Cys Lys Ala Ser Gly Thr Pro Met 
305                 310                 315                 320 


Pro Lys Lys Tyr Ser Trp Phe His Asn Gly Thr Leu Leu Asp Arg Arg 
                325                 330                 335     


Ala His Gly Tyr Gly Ala His Leu Glu Leu Arg Gly Leu Arg Pro Asp 
            340                 345                 350         


Gln Ala Gly Ile Tyr His Cys Lys Ala Trp Asn Glu Ala Gly Ala Val 
        355                 360                 365             


Arg Ser Gly Thr Ala Arg Leu Thr Val Leu Ala Pro Gly Gln Pro Ala 
    370                 375                 380                 


Cys Asp Pro Arg Pro Arg Glu Tyr Leu Ile Lys Leu Pro Glu Asp Cys 
385                 390                 395                 400 


Gly Gln Pro Gly Ser Gly Pro Ala Tyr Leu Asp Val Gly Leu Cys Pro 
                405                 410                 415     


Asp Thr Arg Cys Pro Ser Leu Ala Gly Ser Ser Pro Arg Cys Gly Asp 
            420                 425                 430         


Ala Ser Ser Arg Cys Cys Ser Val Arg Arg Leu Glu Arg Arg Glu Ile 
        435                 440                 445             


His Cys Pro Gly Tyr Val Leu Pro Val Lys Val Val Ala Glu Cys Gly 
    450                 455                 460                 


Cys Gln Lys Cys Leu Pro Pro Arg Gly Leu Val Arg Gly Arg Val Val 
465                 470                 475                 480 


Ala Ala Asp Ser Gly Glu Pro Leu Arg Phe Ala Arg Ile Leu Leu Gly 
                485                 490                 495     


Gln Glu Pro Ile Gly Phe Thr Ala Tyr Gln Gly Asp Phe Thr Ile Glu 
            500                 505                 510         


Val Pro Pro Ser Thr Gln Arg Leu Val Val Thr Phe Val Asp Pro Ser 
        515                 520                 525             


Gly Glu Phe Met Asp Ala Val Arg Val Leu Pro Phe Asp Pro Arg Gly 
    530                 535                 540                 


Ala Gly Val Tyr His Glu Val Lys Ala Met Arg Lys Lys Ala Pro Val 
545                 550                 555                 560 


Ile Leu His Thr Ser Gln Ser Asn Thr Ile Pro Leu Gly Glu Leu Glu 
                565                 570                 575     


Asp Glu Ala Pro Leu Gly Glu Leu Val Leu Pro Ser Gly Ala Phe Arg 
            580                 585                 590         


Arg Ala Asp Gly Lys Pro Tyr Ser Gly Pro Val Glu Ala Arg Val Thr 
        595                 600                 605             


Phe Val Asp Pro Arg Asp Leu Thr Ser Ala Ala Ser Ala Pro Ser Asp 
    610                 615                 620                 


Leu Arg Phe Val Asp Ser Asp Gly Glu Leu Ala Pro Leu Arg Thr Tyr 
625                 630                 635                 640 


Gly Met Phe Ser Val Asp Leu Arg Ala Pro Gly Ser Ala Glu Gln Leu 
                645                 650                 655     


Gln Val Gly Pro Val Ala Val Arg Val Ala Ala Ser Gln Ile His Met 
            660                 665                 670         


Pro Gly His Val Glu Ala Leu Lys Leu Trp Ser Leu Asn Pro Glu Thr 
        675                 680                 685             


Gly Leu Trp Glu Glu Glu Ser Gly Phe Arg Arg Glu Gly Ser Ser Gly 
    690                 695                 700                 


Pro Arg Val Arg Arg Glu Glu Arg Val Phe Leu Val Gly Asn Val Glu 
705                 710                 715                 720 


Ile Arg Glu Arg Arg Leu Phe Asn Leu Asp Val Pro Glu Arg Arg Arg 
                725                 730                 735     


Cys Phe Val Lys Val Arg Ala Tyr Ala Asn Asp Lys Phe Thr Pro Ser 
            740                 745                 750         


Glu Gln Val Glu Gly Val Val Val Thr Leu Val Asn Leu Glu Pro Ala 
        755                 760                 765             


Pro Gly Phe Ser Ala Asn Pro Arg Ala Trp Gly Arg Phe Asp Ser Ala 
    770                 775                 780                 


Val Thr Gly Pro Asn Gly Ala Cys Leu Pro Ala Phe Cys Asp Ala Asp 
785                 790                 795                 800 


Arg Pro Asp Ala Tyr Thr Ala Leu Val Thr Ala Thr Leu Gly Gly Glu 
                805                 810                 815     


Glu Leu Glu Pro Ala Pro Ser Leu Pro Arg Pro Leu Pro Ala Thr Val 
            820                 825                 830         


Gly Val Thr Gln Pro Tyr Leu Asp Arg Leu Gly Tyr Arg Arg Thr Asp 
        835                 840                 845             


His Asp Asp Pro Ala Phe Lys Arg Asn Gly Phe Arg Ile Asn Leu Ala 
    850                 855                 860                 


Lys Pro Arg Pro Gly Asp Pro Ala Glu Ala Asn Gly Pro Val Tyr Pro 
865                 870                 875                 880 


Trp Arg Ser Leu Arg Glu Cys Gln Gly Ala Pro Val Thr Ala Ser His 
                885                 890                 895     


Phe Arg Phe Ala Arg Val Glu Ala Asp Lys Tyr Glu Tyr Asn Val Val 
            900                 905                 910         


Pro Phe Arg Glu Gly Thr Pro Ala Ser Trp Thr Gly Asp Leu Leu Ala 
        915                 920                 925             


Trp Trp Pro Asn Pro Gln Glu Phe Arg Ala Cys Phe Leu Lys Val Lys 
    930                 935                 940                 


Ile Gln Gly Pro Gln Glu Tyr Met Val Arg Ser His Asn Ala Gly Gly 
945                 950                 955                 960 


Ser His Pro Arg Thr Arg Gly Gln Leu Tyr Gly Leu Arg Asp Ala Arg 
                965                 970                 975     


Ser Val Arg Asp Pro Glu Arg Pro Gly Thr Ser Ala Ala Cys Val Glu 
            980                 985                 990         


Phe Lys Cys Ser Gly Met Leu Phe  Asp Gln Arg Gln Val  Asp Arg Thr 
        995                 1000                 1005             


Leu Val  Thr Ile Met Pro Gln  Gly Ser Cys Arg Arg  Val Ala Val 
    1010                 1015                 1020             


Asn Gly  Leu Leu Arg Asp Tyr  Leu Thr Arg His Pro  Pro Pro Val 
    1025                 1030                 1035             


Pro Ala  Glu Asp Pro Ala Ala  Phe Ser Met Leu Ala  Pro Leu Asp 
    1040                 1045                 1050             


Pro Leu  Gly His Asn Tyr Gly  Val Tyr Thr Val Thr  Asp Gln Ser 
    1055                 1060                 1065             


Pro Arg  Leu Ala Lys Glu Ile  Ala Ile Gly Arg Cys  Phe Asp Gly 
    1070                 1075                 1080             


Ser Ser  Asp Gly Phe Ser Arg  Glu Met Lys Ala Asp  Ala Gly Thr 
    1085                 1090                 1095             


Ala Val  Thr Phe Gln Cys Arg  Glu Pro Pro Ala Gly  Arg Pro Ser 
    1100                 1105                 1110             


Leu Phe  Gln Arg Leu Leu Glu  Ser Pro Ala Thr Ala  Leu Gly Asp 
    1115                 1120                 1125             


Ile Arg  Arg Glu Met Ser Glu  Ala Ala Gln Ala Gln  Ala Arg Ala 
    1130                 1135                 1140             


Ser Gly  Pro Leu Arg Thr Arg  Arg Gly Arg Val Arg  Gln 
    1145                 1150                 1155     


<210>  2932
<211>  113
<212>  PRT
<213>  Homo Sapiens

<400>  2932

Met Asp Asn Val Gln Pro Lys Ile Lys His Arg Pro Phe Cys Phe Ser 
1               5                   10                  15      


Val Lys Gly His Val Lys Met Leu Arg Leu Ala Leu Thr Val Thr Ser 
            20                  25                  30          


Met Thr Phe Phe Ile Ile Ala Gln Ala Pro Glu Pro Tyr Ile Val Ile 
        35                  40                  45              


Thr Gly Phe Glu Val Thr Val Ile Leu Phe Phe Ile Leu Leu Tyr Val 
    50                  55                  60                  


Leu Arg Leu Asp Arg Leu Met Lys Trp Leu Phe Trp Pro Leu Leu Asp 
65                  70                  75                  80  


Ile Ile Asn Ser Leu Val Thr Thr Val Phe Met Leu Ile Val Ser Val 
                85                  90                  95      


Leu Ala Leu Ile Pro Glu Thr Thr Thr Leu Thr Val Gly Gly Gly Leu 
            100                 105                 110         


Phe 
    


<210>  2933
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  2933

Met Asp Asn Val Gln Pro Lys Ile Lys His Arg Pro Phe Cys Phe Ser 
1               5                   10                  15      


Val Lys Gly His Val Lys Met Leu Arg Leu Ala Leu Thr Val Thr Ser 
            20                  25                  30          


Met Thr Phe Phe Ile Ile Ala Gln Ala Pro Glu Pro Tyr Ile Val Ile 
        35                  40                  45              


Thr Gly Phe Glu Val Thr Val Ile Leu Phe Phe Ile Leu Leu Tyr Val 
    50                  55                  60                  


Leu Arg Leu Asp Arg Leu Met Lys Trp Leu Phe Trp Pro Leu Leu Asp 
65                  70                  75                  80  


Ile Ile Asn Ser Leu Val Thr Thr Val Phe Met Leu Ile Val Ser Val 
                85                  90                  95      


Leu Ala Leu Ile Pro Glu Thr Thr Thr Leu Thr Val Gly Gly Gly Val 
            100                 105                 110         


Phe Ala Leu Val Thr Ala Val Cys Cys Leu Ala Asp Gly Ala Leu Ile 
        115                 120                 125             


Tyr Arg Lys Leu Leu Phe Asn Pro Ser Gly Pro Tyr Gln Lys Lys Pro 
    130                 135                 140                 


Val His Glu Lys Lys Glu Val Leu 
145                 150         


<210>  2934
<211>  120
<212>  PRT
<213>  Homo Sapiens

<400>  2934

Met Asp Asn Val Gln Pro Lys Ile Lys His Arg Pro Phe Cys Phe Ser 
1               5                   10                  15      


Val Lys Gly His Val Lys Met Leu Arg Leu Ala Leu Thr Val Thr Ser 
            20                  25                  30          


Met Thr Phe Phe Ile Ile Ala Gln Ala Pro Glu Pro Tyr Ile Val Ile 
        35                  40                  45              


Thr Gly Phe Glu Val Thr Val Ile Leu Phe Phe Ile Leu Leu Tyr Val 
    50                  55                  60                  


Leu Arg Leu Asp Arg Leu Met Lys Trp Leu Phe Trp Pro Leu Leu Val 
65                  70                  75                  80  


Phe Ala Leu Val Thr Ala Val Cys Cys Leu Ala Asp Gly Ala Leu Ile 
                85                  90                  95      


Tyr Arg Lys Leu Leu Phe Asn Pro Ser Gly Pro Tyr Gln Lys Lys Pro 
            100                 105                 110         


Val His Glu Lys Lys Glu Val Leu 
        115                 120 


<210>  2935
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  2935

Met Asp Asn Val Gln Pro Lys Ile Lys His Arg Pro Phe Cys Phe Ser 
1               5                   10                  15      


Val Lys Gly His Val Lys Met Leu Arg Leu Asp Ile Ile Asn Ser Leu 
            20                  25                  30          


Val Thr Thr Val Phe Met Leu Ile Val Ser Val Leu Ala Leu Ile Pro 
        35                  40                  45              


Glu Thr Thr Thr Leu Thr Val Gly Gly Gly Val Phe Ala Leu Val Thr 
    50                  55                  60                  


Ala Val Cys Cys Leu Ala Asp Gly Ala Leu Ile Tyr Arg Lys Leu Leu 
65                  70                  75                  80  


Phe Asn Pro Ser Gly Pro Tyr Gln Lys Lys Pro Val His Glu Lys Lys 
                85                  90                  95      


Glu Val Leu 
            


<210>  2936
<211>  33
<212>  PRT
<213>  Homo Sapiens

<400>  2936

Met Asp Asn Val Gln Pro Lys Ile Lys His Arg Pro Phe Cys Phe Ser 
1               5                   10                  15      


Val Lys Gly His Val Lys Met Leu Arg Leu His Cys Leu Val Val Phe 
            20                  25                  30          


Met 
    


<210>  2937
<211>  67
<212>  PRT
<213>  Homo Sapiens

<400>  2937

Met Asp Asn Val Gln Pro Lys Ile Lys His Arg Pro Phe Cys Phe Ser 
1               5                   10                  15      


Val Lys Gly His Val Lys Met Leu Arg Leu Val Phe Ala Leu Val Thr 
            20                  25                  30          


Ala Val Cys Cys Leu Ala Asp Gly Ala Leu Ile Tyr Arg Lys Leu Leu 
        35                  40                  45              


Phe Asn Pro Ser Gly Pro Tyr Gln Lys Lys Pro Val His Glu Lys Lys 
    50                  55                  60                  


Glu Val Leu 
65          


<210>  2938
<211>  69
<212>  PRT
<213>  Homo Sapiens

<400>  2938

Met Ala Gly Pro Phe Ser Arg Leu Leu Ser Ala Arg Pro Gly Leu Arg 
1               5                   10                  15      


Leu Leu Ala Leu Ala Gly Ala Gly Ser Leu Ala Ala Gly Phe Leu Leu 
            20                  25                  30          


Arg Pro Glu Pro Val Arg Ala Ala Ser Glu Arg Arg Arg Leu Tyr Pro 
        35                  40                  45              


Pro Arg Leu Phe Pro Ser Ser Ile Arg Ser Val Val Ser Trp Glu Glu 
    50                  55                  60                  


Arg Thr Glu Gln Ile 
65                  


<210>  2939
<211>  148
<212>  PRT
<213>  Homo Sapiens

<400>  2939

Met Ala Gly Pro Phe Ser Arg Leu Leu Ser Ala Arg Pro Gly Leu Arg 
1               5                   10                  15      


Leu Leu Ala Leu Ala Gly Ala Gly Ser Leu Ala Ala Gly Phe Leu Leu 
            20                  25                  30          


Arg Pro Glu Pro Val Arg Ala Ala Ser Glu Arg Arg Arg Leu Tyr Pro 
        35                  40                  45              


Pro Ser Ala Glu Tyr Pro Asp Leu Arg Lys His Asn Asn Cys Met Ala 
    50                  55                  60                  


Ser His Leu Thr Pro Ala Val Tyr Ala Arg Leu Cys Asp Lys Thr Thr 
65                  70                  75                  80  


Pro Thr Gly Trp Thr Leu Asp Gln Cys Ile Gln Thr Gly Val Asp Asn 
                85                  90                  95      


Pro Gly His Pro Phe Ile Lys Thr Val Gly Met Val Ala Gly Asp Glu 
            100                 105                 110         


Glu Thr Tyr Glu Val Phe Ala Asp Leu Phe Asp Pro Val Ile Gln Glu 
        115                 120                 125             


Arg His Asn Gly Tyr Asp Pro Arg Thr Met Lys His Thr Thr Asp Leu 
    130                 135                 140                 


Asp Ala Ser Lys 
145             


<210>  2940
<211>  417
<212>  PRT
<213>  Homo Sapiens

<400>  2940

Met Ala Gly Pro Phe Ser Arg Leu Leu Ser Ala Arg Pro Gly Leu Arg 
1               5                   10                  15      


Leu Leu Ala Leu Ala Gly Ala Gly Ser Leu Ala Ala Gly Phe Leu Leu 
            20                  25                  30          


Arg Pro Glu Pro Val Arg Ala Ala Ser Glu Arg Arg Arg Leu Tyr Pro 
        35                  40                  45              


Pro Ser Ala Glu Tyr Pro Asp Leu Arg Lys His Asn Asn Cys Met Ala 
    50                  55                  60                  


Ser His Leu Thr Pro Ala Val Tyr Ala Arg Leu Cys Asp Lys Thr Thr 
65                  70                  75                  80  


Pro Thr Gly Trp Thr Leu Asp Gln Cys Ile Gln Thr Gly Val Asp Asn 
                85                  90                  95      


Pro Gly His Pro Phe Ile Lys Thr Val Gly Met Val Ala Gly Asp Glu 
            100                 105                 110         


Glu Thr Tyr Glu Val Phe Ala Asp Leu Phe Asp Pro Val Ile Gln Glu 
        115                 120                 125             


Arg His Asn Gly Tyr Asp Pro Arg Thr Met Lys His Thr Thr Asp Leu 
    130                 135                 140                 


Asp Ala Ser Lys Ile Arg Ser Gly Tyr Phe Asp Glu Arg Tyr Val Leu 
145                 150                 155                 160 


Ser Ser Arg Val Arg Thr Gly Arg Ser Ile Arg Gly Leu Ser Leu Pro 
                165                 170                 175     


Pro Ala Cys Thr Arg Ala Glu Arg Arg Glu Val Glu Arg Val Val Val 
            180                 185                 190         


Asp Ala Leu Ser Gly Leu Lys Gly Asp Leu Ala Gly Arg Tyr Tyr Arg 
        195                 200                 205             


Leu Ser Glu Met Thr Glu Ala Glu Gln Gln Gln Leu Ile Asp Asp His 
    210                 215                 220                 


Phe Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Thr Ala Ala Gly Met 
225                 230                 235                 240 


Ala Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Asn Glu Lys 
                245                 250                 255     


Ser Phe Leu Ile Trp Val Asn Glu Glu Asp His Thr Arg Val Ile Ser 
            260                 265                 270         


Met Glu Lys Gly Gly Asn Met Lys Arg Val Phe Glu Arg Phe Cys Arg 
        275                 280                 285             


Gly Leu Lys Glu Val Glu Arg Leu Ile Gln Glu Arg Gly Trp Glu Phe 
    290                 295                 300                 


Met Trp Asn Glu Arg Leu Gly Tyr Ile Leu Thr Cys Pro Ser Asn Leu 
305                 310                 315                 320 


Gly Thr Gly Leu Arg Ala Gly Val His Ile Lys Leu Pro Leu Leu Ser 
                325                 330                 335     


Lys Asp Ser Arg Phe Pro Lys Ile Leu Glu Asn Leu Arg Leu Gln Lys 
            340                 345                 350         


Arg Gly Thr Gly Gly Val Asp Thr Ala Ala Thr Gly Gly Val Phe Asp 
        355                 360                 365             


Ile Ser Asn Leu Asp Arg Leu Gly Lys Ser Glu Val Glu Leu Val Gln 
    370                 375                 380                 


Leu Val Ile Asp Gly Val Asn Tyr Leu Ile Asp Cys Glu Arg Arg Leu 
385                 390                 395                 400 


Glu Arg Gly Gln Asp Ile Arg Ile Pro Thr Pro Val Ile His Thr Lys 
                405                 410                 415     


His 
    


<210>  2941
<211>  417
<212>  PRT
<213>  Homo Sapiens

<400>  2941

Met Ala Gly Pro Phe Ser Arg Leu Leu Ser Ala Arg Pro Gly Leu Arg 
1               5                   10                  15      


Leu Leu Ala Leu Ala Gly Ala Gly Ser Leu Ala Ala Gly Phe Leu Leu 
            20                  25                  30          


Arg Pro Glu Pro Val Arg Ala Ala Ser Glu Arg Arg Arg Leu Tyr Pro 
        35                  40                  45              


Pro Ser Ala Glu Tyr Pro Asp Leu Arg Lys His Asn Asn Cys Met Ala 
    50                  55                  60                  


Ser His Leu Thr Pro Ala Val Tyr Ala Arg Leu Cys Asp Lys Thr Thr 
65                  70                  75                  80  


Pro Thr Gly Trp Thr Leu Asp Gln Cys Ile Gln Thr Gly Val Asp Asn 
                85                  90                  95      


Pro Gly His Pro Phe Ile Lys Thr Val Gly Met Val Ala Gly Asp Glu 
            100                 105                 110         


Glu Thr Tyr Glu Val Phe Ala Asp Leu Phe Asp Pro Val Ile Gln Glu 
        115                 120                 125             


Arg His Asn Gly Tyr Asp Pro Arg Thr Met Lys His Thr Thr Asp Leu 
    130                 135                 140                 


Asp Ala Ser Lys Ile Arg Ser Gly Tyr Phe Asp Glu Arg Tyr Val Leu 
145                 150                 155                 160 


Ser Ser Arg Val Arg Thr Gly Arg Ser Ile Arg Gly Leu Ser Leu Pro 
                165                 170                 175     


Pro Ala Cys Thr Arg Ala Glu Arg Arg Glu Val Glu Arg Val Val Val 
            180                 185                 190         


Asp Ala Leu Ser Gly Leu Lys Gly Asp Leu Ala Gly Arg Tyr Tyr Arg 
        195                 200                 205             


Leu Ser Glu Met Thr Glu Ala Glu Gln Gln Gln Leu Ile Asp Asp His 
    210                 215                 220                 


Phe Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Thr Ala Ala Gly Met 
225                 230                 235                 240 


Ala Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Asn Glu Lys 
                245                 250                 255     


Ser Phe Leu Ile Trp Val Asn Glu Glu Asp His Thr Arg Val Ile Ser 
            260                 265                 270         


Met Glu Lys Gly Gly Asn Met Lys Arg Val Phe Glu Arg Phe Cys Arg 
        275                 280                 285             


Gly Leu Lys Glu Val Glu Arg Leu Ile Gln Glu Arg Gly Trp Glu Phe 
    290                 295                 300                 


Met Trp Asn Glu Arg Leu Gly Tyr Ile Leu Thr Cys Pro Ser Asn Leu 
305                 310                 315                 320 


Gly Thr Gly Leu Arg Ala Gly Val His Ile Lys Leu Pro Leu Leu Ser 
                325                 330                 335     


Lys Asp Ser Arg Phe Pro Lys Ile Leu Glu Asn Leu Arg Leu Gln Lys 
            340                 345                 350         


Arg Gly Thr Gly Gly Val Asp Thr Ala Ala Thr Gly Gly Val Phe Asp 
        355                 360                 365             


Ile Ser Asn Leu Asp Arg Leu Gly Lys Ser Glu Val Glu Leu Val Gln 
    370                 375                 380                 


Leu Val Ile Asp Gly Val Asn Tyr Leu Ile Asp Cys Glu Arg Arg Leu 
385                 390                 395                 400 


Glu Arg Gly Gln Asp Ile Arg Ile Pro Thr Pro Val Ile His Thr Lys 
                405                 410                 415     


His 
    


<210>  2942
<211>  298
<212>  PRT
<213>  Homo Sapiens

<400>  2942

Met Ala Gly Pro Phe Ser Arg Leu Leu Ser Ala Arg Pro Gly Leu Arg 
1               5                   10                  15      


Leu Leu Ala Leu Ala Gly Ala Gly Ser Leu Ala Ala Gly Phe Leu Leu 
            20                  25                  30          


Arg Pro Glu Pro Val Arg Ala Ala Ser Glu Arg Arg Arg Leu Tyr Pro 
        35                  40                  45              


Pro Ser Ala Glu Tyr Pro Asp Leu Arg Lys His Asn Asn Cys Met Ala 
    50                  55                  60                  


Ser His Leu Thr Pro Ala Val Tyr Ala Arg Leu Cys Asp Lys Thr Thr 
65                  70                  75                  80  


Pro Thr Gly Trp Thr Leu Asp Gln Cys Ile Gln Thr Gly Val Asp Asn 
                85                  90                  95      


Pro Gly His Pro Phe Ile Lys Thr Val Gly Met Val Ala Gly Asp Glu 
            100                 105                 110         


Glu Thr Tyr Glu Val Phe Ala Asp Leu Phe Asp Pro Val Ile Gln Glu 
        115                 120                 125             


Arg His Asn Gly Tyr Asp Pro Arg Thr Met Lys His Thr Thr Asp Leu 
    130                 135                 140                 


Asp Ala Ser Lys Ile Arg Ser Gly Tyr Phe Asp Glu Arg Tyr Val Leu 
145                 150                 155                 160 


Ser Ser Arg Val Arg Thr Gly Arg Ser Ile Arg Gly Leu Ser Leu Pro 
                165                 170                 175     


Pro Ala Cys Thr Arg Ala Glu Arg Arg Glu Val Glu Arg Val Val Val 
            180                 185                 190         


Asp Ala Leu Ser Gly Leu Lys Gly Asp Leu Ala Gly Arg Tyr Tyr Arg 
        195                 200                 205             


Leu Ser Glu Met Thr Glu Ala Glu Gln Gln Gln Leu Ile Asp Asp His 
    210                 215                 220                 


Phe Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Thr Ala Ala Gly Met 
225                 230                 235                 240 


Ala Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Asn Glu Lys 
                245                 250                 255     


Ser Phe Leu Ile Trp Val Asn Glu Glu Asp His Thr Arg Val Ile Ser 
            260                 265                 270         


Met Glu Lys Gly Gly Asn Met Lys Arg Val Phe Glu Arg Phe Cys Arg 
        275                 280                 285             


Gly Leu Lys Glu Val Val Val Gly Ile Lys 
    290                 295             


<210>  2943
<211>  222
<212>  PRT
<213>  Homo Sapiens

<400>  2943

Met Ala Gly Pro Phe Ser Arg Leu Leu Ser Ala Arg Pro Gly Leu Arg 
1               5                   10                  15      


Leu Leu Ala Leu Ala Gly Ala Gly Ser Leu Ala Ala Gly Phe Leu Leu 
            20                  25                  30          


Arg Pro Glu Pro Val Arg Ala Ala Ser Glu Arg Arg Arg Leu Tyr Pro 
        35                  40                  45              


Pro Ser Gln Thr Trp Pro Thr Gly Gln Leu Pro Gly Asn Cys Thr Arg 
    50                  55                  60                  


Ser Arg Arg Leu Cys Pro Pro Ser Met Val Thr Gly Tyr Pro Leu Pro 
65                  70                  75                  80  


Ser Ala Glu Tyr Pro Asp Leu Arg Lys His Asn Asn Cys Met Ala Ser 
                85                  90                  95      


His Leu Thr Pro Ala Val Tyr Ala Arg Leu Cys Asp Lys Thr Thr Pro 
            100                 105                 110         


Thr Gly Trp Thr Leu Asp Gln Cys Ile Gln Thr Gly Val Asp Asn Pro 
        115                 120                 125             


Gly His Pro Phe Ile Lys Thr Val Gly Met Val Ala Gly Asp Glu Glu 
    130                 135                 140                 


Thr Tyr Glu Val Phe Ala Asp Leu Phe Asp Pro Val Ile Gln Glu Arg 
145                 150                 155                 160 


His Asn Gly Tyr Asp Pro Arg Thr Met Lys His Thr Thr Asp Leu Asp 
                165                 170                 175     


Ala Ser Lys Ile Arg Ser Gly Tyr Phe Asp Glu Arg Tyr Val Leu Ser 
            180                 185                 190         


Ser Arg Val Arg Thr Gly Arg Ser Ile Arg Gly Leu Ser Leu Pro Pro 
        195                 200                 205             


Ala Cys Thr Arg Ala Glu Arg Arg Glu Val Glu Arg Val Val 
    210                 215                 220         


<210>  2944
<211>  58
<212>  PRT
<213>  Homo Sapiens

<400>  2944

Met Ala Gly Pro Phe Ser Arg Leu Leu Ser Ala Arg Pro Gly Leu Arg 
1               5                   10                  15      


Leu Leu Ala Leu Ala Gly Ala Gly Ser Leu Ala Ala Gly Phe Leu Leu 
            20                  25                  30          


Arg Pro Glu Pro Val Arg Ala Ala Ser Glu Arg Arg Arg Leu Tyr Pro 
        35                  40                  45              


Pro Arg Tyr Leu Leu Thr Cys Leu Thr Leu 
    50                  55              


<210>  2945
<211>  103
<212>  PRT
<213>  Homo Sapiens

<400>  2945

Met Ala Gly Pro Phe Ser Arg Leu Leu Ser Ala Arg Pro Gly Leu Arg 
1               5                   10                  15      


Leu Leu Ala Leu Ala Gly Ala Gly Ser Leu Ala Ala Gly Phe Leu Leu 
            20                  25                  30          


Arg Pro Glu Pro Val Arg Ala Ala Ser Glu Arg Arg Arg Leu Tyr Pro 
        35                  40                  45              


Pro Ser Ala Glu Tyr Pro Asp Leu Arg Lys His Asn Asn Cys Met Ala 
    50                  55                  60                  


Ser His Leu Thr Pro Ala Val Tyr Ala Arg Leu Cys Asp Lys Thr Thr 
65                  70                  75                  80  


Pro Thr Gly Trp Thr Leu Asp Gln Cys Ile Gln Thr Gly Val Asp Asn 
                85                  90                  95      


Pro Gly His Pro Phe Ile Lys 
            100             


<210>  2946
<211>  129
<212>  PRT
<213>  Homo Sapiens

<400>  2946

Met Ala Gly Pro Phe Ser Arg Leu Leu Ser Ala Arg Pro Gly Leu Arg 
1               5                   10                  15      


Leu Leu Ala Leu Ala Gly Ala Gly Ser Leu Ala Ala Gly Phe Leu Leu 
            20                  25                  30          


Arg Pro Glu Pro Val Arg Ala Ala Ser Glu Arg Arg Arg Leu Tyr Pro 
        35                  40                  45              


Pro Ser Ala Glu Tyr Pro Asp Leu Arg Lys His Asn Asn Cys Met Ala 
    50                  55                  60                  


Ser His Leu Thr Pro Ala Val Tyr Ala Arg Leu Cys Asp Lys Thr Thr 
65                  70                  75                  80  


Pro Thr Gly Trp Thr Leu Asp Gln Cys Ile Gln Thr Gly Val Asp Asn 
                85                  90                  95      


Pro Gly His Pro Phe Ile Lys Thr Val Gly Met Val Ala Gly Asp Glu 
            100                 105                 110         


Glu Thr Tyr Glu Val Phe Ala Asp Leu Phe Asp Pro Val Ile Gln Glu 
        115                 120                 125             


Arg 
    


<210>  2947
<211>  241
<212>  PRT
<213>  Homo Sapiens

<400>  2947

Met Ala Gly Pro Phe Ser Arg Leu Leu Ser Ala Arg Pro Gly Leu Arg 
1               5                   10                  15      


Leu Leu Ala Leu Ala Gly Ala Gly Ser Leu Ala Ala Gly Phe Leu Leu 
            20                  25                  30          


Arg Pro Glu Pro Val Arg Ala Ala Ser Glu Arg Arg Arg Leu Tyr Pro 
        35                  40                  45              


Pro Ser Ala Glu Tyr Pro Asp Leu Arg Lys His Asn Asn Cys Met Ala 
    50                  55                  60                  


Ser His Leu Thr Pro Ala Val Tyr Ala Arg Leu Cys Asp Lys Thr Thr 
65                  70                  75                  80  


Pro Thr Gly Trp Thr Leu Asp Gln Cys Ile Gln Thr Gly Val Asp Asn 
                85                  90                  95      


Pro Gly His Pro Phe Ile Lys Thr Val Gly Met Val Ala Gly Asp Glu 
            100                 105                 110         


Glu Thr Tyr Glu Val Phe Ala Asp Leu Phe Asp Pro Val Ile Gln Glu 
        115                 120                 125             


Arg His Asn Gly Tyr Asp Pro Arg Thr Met Lys His Thr Thr Asp Leu 
    130                 135                 140                 


Asp Ala Ser Lys Ile Arg Ser Gly Tyr Phe Asp Glu Arg Tyr Val Leu 
145                 150                 155                 160 


Ser Ser Arg Val Arg Thr Gly Arg Ser Ile Arg Gly Leu Ser Leu Pro 
                165                 170                 175     


Pro Ala Cys Thr Arg Ala Glu Arg Arg Glu Val Glu Arg Val Val Val 
            180                 185                 190         


Asp Ala Leu Ser Gly Leu Lys Gly Asp Leu Ala Gly Arg Tyr Tyr Arg 
        195                 200                 205             


Leu Ser Glu Met Thr Glu Ala Glu Gln Gln Gln Leu Ile Asp Asp His 
    210                 215                 220                 


Phe Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Thr Ala Ala Gly Met 
225                 230                 235                 240 


Ala 
    


<210>  2948
<211>  417
<212>  PRT
<213>  Homo Sapiens

<400>  2948

Met Ala Gly Pro Phe Ser Arg Leu Leu Ser Ala Arg Pro Gly Leu Arg 
1               5                   10                  15      


Leu Leu Ala Leu Ala Gly Ala Gly Ser Leu Ala Ala Gly Phe Leu Leu 
            20                  25                  30          


Arg Pro Glu Pro Val Arg Ala Ala Ser Glu Arg Arg Arg Leu Tyr Pro 
        35                  40                  45              


Pro Ser Ala Glu Tyr Pro Asp Leu Arg Lys His Asn Asn Cys Met Ala 
    50                  55                  60                  


Ser His Leu Thr Pro Ala Val Tyr Ala Arg Leu Cys Asp Lys Thr Thr 
65                  70                  75                  80  


Pro Thr Gly Trp Thr Leu Asp Gln Cys Ile Gln Thr Gly Val Asp Asn 
                85                  90                  95      


Pro Gly His Pro Phe Ile Lys Thr Val Gly Met Val Ala Gly Asp Glu 
            100                 105                 110         


Glu Thr Tyr Glu Val Phe Ala Asp Leu Phe Asp Pro Val Ile Gln Glu 
        115                 120                 125             


Arg His Asn Gly Tyr Asp Pro Arg Thr Met Lys His Thr Thr Asp Leu 
    130                 135                 140                 


Asp Ala Ser Lys Ile Arg Ser Gly Tyr Phe Asp Glu Arg Tyr Val Leu 
145                 150                 155                 160 


Ser Ser Arg Val Arg Thr Gly Arg Ser Ile Arg Gly Leu Ser Leu Pro 
                165                 170                 175     


Pro Ala Cys Thr Arg Ala Glu Arg Arg Glu Val Glu Arg Val Val Val 
            180                 185                 190         


Asp Ala Leu Ser Gly Leu Lys Gly Asp Leu Ala Gly Arg Tyr Tyr Arg 
        195                 200                 205             


Leu Ser Glu Met Thr Glu Ala Glu Gln Gln Gln Leu Ile Asp Asp His 
    210                 215                 220                 


Phe Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Thr Ala Ala Gly Met 
225                 230                 235                 240 


Ala Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Asn Glu Lys 
                245                 250                 255     


Ser Phe Leu Ile Trp Val Asn Glu Glu Asp His Thr Arg Val Ile Ser 
            260                 265                 270         


Met Glu Lys Gly Gly Asn Met Lys Arg Val Phe Glu Arg Phe Cys Arg 
        275                 280                 285             


Gly Leu Lys Glu Val Glu Arg Leu Ile Gln Glu Arg Gly Trp Glu Phe 
    290                 295                 300                 


Met Trp Asn Glu Arg Leu Gly Tyr Ile Leu Thr Cys Pro Ser Asn Leu 
305                 310                 315                 320 


Gly Thr Gly Leu Arg Ala Gly Val His Ile Lys Leu Pro Leu Leu Ser 
                325                 330                 335     


Lys Asp Ser Arg Phe Pro Lys Ile Leu Glu Asn Leu Arg Leu Gln Lys 
            340                 345                 350         


Arg Gly Thr Gly Gly Val Asp Thr Ala Ala Thr Gly Gly Val Phe Asp 
        355                 360                 365             


Ile Ser Asn Leu Asp Arg Leu Gly Lys Ser Glu Val Glu Leu Val Gln 
    370                 375                 380                 


Leu Val Ile Asp Gly Val Asn Tyr Leu Ile Asp Cys Glu Arg Arg Leu 
385                 390                 395                 400 


Glu Arg Gly Gln Asp Ile Arg Ile Pro Thr Pro Val Ile His Thr Lys 
                405                 410                 415     


His 
    


<210>  2949
<211>  298
<212>  PRT
<213>  Homo Sapiens

<400>  2949

Met Ala Gly Pro Phe Ser Arg Leu Leu Ser Ala Arg Pro Gly Leu Arg 
1               5                   10                  15      


Leu Leu Ala Leu Ala Gly Ala Gly Ser Leu Ala Ala Gly Phe Leu Leu 
            20                  25                  30          


Arg Pro Glu Pro Val Arg Ala Ala Ser Glu Arg Arg Arg Leu Tyr Pro 
        35                  40                  45              


Pro Ser Ala Glu Tyr Pro Asp Leu Arg Lys His Asn Asn Cys Met Ala 
    50                  55                  60                  


Ser His Leu Thr Pro Ala Val Tyr Ala Arg Leu Cys Asp Lys Thr Thr 
65                  70                  75                  80  


Pro Thr Gly Trp Thr Leu Asp Gln Cys Ile Gln Thr Gly Val Asp Asn 
                85                  90                  95      


Pro Gly His Pro Phe Ile Lys Thr Val Gly Met Val Ala Gly Asp Glu 
            100                 105                 110         


Glu Thr Tyr Glu Val Phe Ala Asp Leu Phe Asp Pro Val Ile Gln Glu 
        115                 120                 125             


Arg His Asn Gly Tyr Asp Pro Arg Thr Met Lys His Thr Thr Asp Leu 
    130                 135                 140                 


Asp Ala Ser Lys Ile Arg Ser Gly Tyr Phe Asp Glu Arg Tyr Val Leu 
145                 150                 155                 160 


Ser Ser Arg Val Arg Thr Gly Arg Ser Ile Arg Gly Leu Ser Leu Pro 
                165                 170                 175     


Pro Ala Cys Thr Arg Ala Glu Arg Arg Glu Val Glu Arg Val Val Val 
            180                 185                 190         


Asp Ala Leu Ser Gly Leu Lys Gly Asp Leu Ala Gly Arg Tyr Tyr Arg 
        195                 200                 205             


Leu Ser Glu Met Thr Glu Ala Glu Gln Gln Gln Leu Ile Asp Asp His 
    210                 215                 220                 


Phe Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Thr Ala Ala Gly Met 
225                 230                 235                 240 


Ala Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Asn Glu Lys 
                245                 250                 255     


Ser Phe Leu Ile Trp Val Asn Glu Glu Asp His Thr Arg Val Ile Ser 
            260                 265                 270         


Met Glu Lys Gly Gly Asn Met Lys Arg Val Phe Glu Arg Phe Cys Arg 
        275                 280                 285             


Gly Leu Lys Glu Val Val Val Gly Ile Lys 
    290                 295             


<210>  2950
<211>  417
<212>  PRT
<213>  Homo Sapiens

<400>  2950

Met Ala Gly Pro Phe Ser Arg Leu Leu Ser Ala Arg Pro Gly Leu Arg 
1               5                   10                  15      


Leu Leu Ala Leu Ala Gly Ala Gly Ser Leu Ala Ala Gly Phe Leu Leu 
            20                  25                  30          


Arg Pro Glu Pro Val Arg Ala Ala Ser Glu Arg Arg Arg Leu Tyr Pro 
        35                  40                  45              


Pro Ser Ala Glu Tyr Pro Asp Leu Arg Lys His Asn Asn Cys Met Ala 
    50                  55                  60                  


Ser His Leu Thr Pro Ala Val Tyr Ala Arg Leu Cys Asp Lys Thr Thr 
65                  70                  75                  80  


Pro Thr Gly Trp Thr Leu Asp Gln Cys Ile Gln Thr Gly Val Asp Asn 
                85                  90                  95      


Pro Gly His Pro Phe Ile Lys Thr Val Gly Met Val Ala Gly Asp Glu 
            100                 105                 110         


Glu Thr Tyr Glu Val Phe Ala Asp Leu Phe Asp Pro Val Ile Gln Glu 
        115                 120                 125             


Arg His Asn Gly Tyr Asp Pro Arg Thr Met Lys His Thr Thr Asp Leu 
    130                 135                 140                 


Asp Ala Ser Lys Ile Arg Ser Gly Tyr Phe Asp Glu Arg Tyr Val Leu 
145                 150                 155                 160 


Ser Ser Arg Val Arg Thr Gly Arg Ser Ile Arg Gly Leu Ser Leu Pro 
                165                 170                 175     


Pro Ala Cys Thr Arg Ala Glu Arg Arg Glu Val Glu Arg Val Val Val 
            180                 185                 190         


Asp Ala Leu Ser Gly Leu Lys Gly Asp Leu Ala Gly Arg Tyr Tyr Arg 
        195                 200                 205             


Leu Ser Glu Met Thr Glu Ala Glu Gln Gln Gln Leu Ile Asp Asp His 
    210                 215                 220                 


Phe Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Thr Ala Ala Gly Met 
225                 230                 235                 240 


Ala Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Asn Glu Lys 
                245                 250                 255     


Ser Phe Leu Ile Trp Val Asn Glu Glu Asp His Thr Arg Val Ile Ser 
            260                 265                 270         


Met Glu Lys Gly Gly Asn Met Lys Arg Val Phe Glu Arg Phe Cys Arg 
        275                 280                 285             


Gly Leu Lys Glu Val Glu Arg Leu Ile Gln Glu Arg Gly Trp Glu Phe 
    290                 295                 300                 


Met Trp Asn Glu Arg Leu Gly Tyr Ile Leu Thr Cys Pro Ser Asn Leu 
305                 310                 315                 320 


Gly Thr Gly Leu Arg Ala Gly Val His Ile Lys Leu Pro Leu Leu Ser 
                325                 330                 335     


Lys Asp Ser Arg Phe Pro Lys Ile Leu Glu Asn Leu Arg Leu Gln Lys 
            340                 345                 350         


Arg Gly Thr Gly Gly Val Asp Thr Ala Ala Thr Gly Gly Val Phe Asp 
        355                 360                 365             


Ile Ser Asn Leu Asp Arg Leu Gly Lys Ser Glu Val Glu Leu Val Gln 
    370                 375                 380                 


Leu Val Ile Asp Gly Val Asn Tyr Leu Ile Asp Cys Glu Arg Arg Leu 
385                 390                 395                 400 


Glu Arg Gly Gln Asp Ile Arg Ile Pro Thr Pro Val Ile His Thr Lys 
                405                 410                 415     


His 
    


<210>  2951
<211>  298
<212>  PRT
<213>  Homo Sapiens

<400>  2951

Met Ala Gly Pro Phe Ser Arg Leu Leu Ser Ala Arg Pro Gly Leu Arg 
1               5                   10                  15      


Leu Leu Ala Leu Ala Gly Ala Gly Ser Leu Ala Ala Gly Phe Leu Leu 
            20                  25                  30          


Arg Pro Glu Pro Val Arg Ala Ala Ser Glu Arg Arg Arg Leu Tyr Pro 
        35                  40                  45              


Pro Ser Ala Glu Tyr Pro Asp Leu Arg Lys His Asn Asn Cys Met Ala 
    50                  55                  60                  


Ser His Leu Thr Pro Ala Val Tyr Ala Arg Leu Cys Asp Lys Thr Thr 
65                  70                  75                  80  


Pro Thr Gly Trp Thr Leu Asp Gln Cys Ile Gln Thr Gly Val Asp Asn 
                85                  90                  95      


Pro Gly His Pro Phe Ile Lys Thr Val Gly Met Val Ala Gly Asp Glu 
            100                 105                 110         


Glu Thr Tyr Glu Val Phe Ala Asp Leu Phe Asp Pro Val Ile Gln Glu 
        115                 120                 125             


Arg His Asn Gly Tyr Asp Pro Arg Thr Met Lys His Thr Thr Asp Leu 
    130                 135                 140                 


Asp Ala Ser Lys Ile Arg Ser Gly Tyr Phe Asp Glu Arg Tyr Val Leu 
145                 150                 155                 160 


Ser Ser Arg Val Arg Thr Gly Arg Ser Ile Arg Gly Leu Ser Leu Pro 
                165                 170                 175     


Pro Ala Cys Thr Arg Ala Glu Arg Arg Glu Val Glu Arg Val Val Val 
            180                 185                 190         


Asp Ala Leu Ser Gly Leu Lys Gly Asp Leu Ala Gly Arg Tyr Tyr Arg 
        195                 200                 205             


Leu Ser Glu Met Thr Glu Ala Glu Gln Gln Gln Leu Ile Asp Asp His 
    210                 215                 220                 


Phe Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Thr Ala Ala Gly Met 
225                 230                 235                 240 


Ala Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Asn Glu Lys 
                245                 250                 255     


Ser Phe Leu Ile Trp Val Asn Glu Glu Asp His Thr Arg Val Ile Ser 
            260                 265                 270         


Met Glu Lys Gly Gly Asn Met Lys Arg Val Phe Glu Arg Phe Cys Arg 
        275                 280                 285             


Gly Leu Lys Glu Val Val Val Gly Ile Lys 
    290                 295             


<210>  2952
<211>  96
<212>  PRT
<213>  Homo Sapiens

<400>  2952

Met Ala Gly Pro Phe Ser Arg Leu Leu Ser Ala Arg Pro Gly Leu Arg 
1               5                   10                  15      


Leu Leu Ala Leu Ala Gly Ala Gly Ser Leu Ala Ala Gly Phe Leu Leu 
            20                  25                  30          


Arg Pro Glu Pro Val Arg Ala Ala Ser Glu Arg Arg Arg Leu Tyr Pro 
        35                  40                  45              


Pro Ser Gln Thr Trp Pro Thr Gly Gln Leu Pro Gly Asn Cys Thr Arg 
    50                  55                  60                  


Ser Arg Arg Leu Cys Pro Pro Ser Met Val Thr Gly Tyr Pro Leu Pro 
65                  70                  75                  80  


Ser Ala Glu Tyr Pro Asp Leu Arg Lys His Asn Asn Cys Met Ala Ser 
                85                  90                  95      


<210>  2953
<211>  203
<212>  PRT
<213>  Homo Sapiens

<400>  2953

Met Ala Gly Pro Phe Ser Arg Leu Leu Ser Ala Arg Pro Gly Leu Arg 
1               5                   10                  15      


Leu Leu Ala Leu Ala Gly Ala Gly Ser Leu Ala Ala Gly Phe Leu Leu 
            20                  25                  30          


Arg Pro Glu Pro Val Arg Ala Ala Ser Glu Arg Arg Arg Leu Tyr Pro 
        35                  40                  45              


Pro Ser Gln Thr Trp Pro Thr Gly Gln Leu Pro Gly Asn Cys Thr Arg 
    50                  55                  60                  


Ser Arg Arg Leu Cys Pro Pro Ser Met Val Thr Gly Tyr Pro Leu Pro 
65                  70                  75                  80  


Ser Ala Glu Tyr Pro Asp Leu Arg Lys His Asn Asn Cys Met Ala Ser 
                85                  90                  95      


His Leu Thr Pro Ala Val Tyr Ala Arg Leu Cys Asp Lys Thr Thr Pro 
            100                 105                 110         


Thr Gly Trp Thr Leu Asp Gln Cys Ile Gln Thr Gly Val Asp Asn Pro 
        115                 120                 125             


Gly His Pro Phe Ile Lys Thr Val Gly Met Val Ala Gly Asp Glu Glu 
    130                 135                 140                 


Thr Tyr Glu Val Phe Ala Asp Leu Phe Asp Pro Val Ile Gln Glu Arg 
145                 150                 155                 160 


His Asn Gly Tyr Asp Pro Arg Thr Met Lys His Thr Thr Asp Leu Asp 
                165                 170                 175     


Ala Ser Lys Ile Arg Ser Gly Tyr Phe Asp Glu Arg Tyr Val Leu Ser 
            180                 185                 190         


Ser Arg Val Arg Thr Gly Arg Ser Ile Arg Gly 
        195                 200             


<210>  2954
<211>  914
<212>  PRT
<213>  Homo Sapiens

<400>  2954

Met Gly Pro Phe Lys Ser Ser Val Phe Ile Leu Ile Leu His Leu Leu 
1               5                   10                  15      


Glu Gly Ala Leu Ser Asn Ser Leu Ile Gln Leu Asn Asn Asn Gly Tyr 
            20                  25                  30          


Glu Gly Ile Val Val Ala Ile Asp Pro Asn Val Pro Glu Asp Glu Thr 
        35                  40                  45              


Leu Ile Gln Gln Ile Lys Asp Met Val Thr Gln Ala Ser Leu Tyr Leu 
    50                  55                  60                  


Leu Glu Ala Thr Gly Lys Arg Phe Tyr Phe Lys Asn Val Ala Ile Leu 
65                  70                  75                  80  


Ile Pro Glu Thr Trp Lys Thr Lys Ala Asp Tyr Val Arg Pro Lys Leu 
                85                  90                  95      


Glu Thr Tyr Lys Asn Ala Asp Val Leu Val Ala Glu Ser Thr Pro Pro 
            100                 105                 110         


Gly Asn Asp Glu Pro Tyr Thr Glu Gln Met Gly Asn Cys Gly Glu Lys 
        115                 120                 125             


Gly Glu Arg Ile His Leu Thr Pro Asp Phe Ile Ala Gly Lys Lys Leu 
    130                 135                 140                 


Ala Glu Tyr Gly Pro Gln Gly Arg Ala Phe Val His Glu Trp Ala His 
145                 150                 155                 160 


Leu Arg Trp Gly Val Phe Asp Glu Tyr Asn Asn Asp Glu Lys Phe Tyr 
                165                 170                 175     


Leu Ser Asn Gly Arg Ile Gln Ala Val Arg Cys Ser Ala Gly Ile Thr 
            180                 185                 190         


Gly Thr Asn Val Val Lys Lys Cys Gln Gly Gly Ser Cys Tyr Thr Lys 
        195                 200                 205             


Arg Cys Thr Phe Asn Lys Val Thr Gly Leu Tyr Glu Lys Gly Cys Glu 
    210                 215                 220                 


Phe Val Leu Gln Ser Arg Gln Thr Glu Lys Ala Ser Ile Met Phe Ala 
225                 230                 235                 240 


Gln His Val Asp Ser Ile Val Glu Phe Cys Thr Glu Gln Asn His Asn 
                245                 250                 255     


Lys Glu Ala Pro Asn Lys Gln Asn Gln Lys Cys Asn Leu Arg Ser Thr 
            260                 265                 270         


Trp Glu Val Ile Arg Asp Ser Glu Asp Phe Lys Lys Thr Thr Pro Met 
        275                 280                 285             


Thr Thr Gln Pro Pro Asn Pro Thr Phe Ser Leu Leu Gln Ile Gly Gln 
    290                 295                 300                 


Arg Ile Val Cys Leu Val Leu Asp Lys Ser Gly Ser Met Ala Thr Gly 
305                 310                 315                 320 


Asn Arg Leu Asn Arg Leu Asn Gln Ala Gly Gln Leu Phe Leu Leu Gln 
                325                 330                 335     


Thr Val Glu Leu Gly Ser Trp Val Gly Met Val Thr Phe Asp Ser Ala 
            340                 345                 350         


Ala His Val Gln Asn Glu Leu Ile Gln Ile Asn Ser Gly Ser Asp Arg 
        355                 360                 365             


Asp Thr Leu Ala Lys Arg Leu Pro Ala Ala Ala Ser Gly Gly Thr Ser 
    370                 375                 380                 


Ile Cys Ser Gly Leu Arg Ser Ala Phe Thr Val Ile Arg Lys Lys Tyr 
385                 390                 395                 400 


Pro Thr Asp Gly Ser Glu Ile Val Leu Leu Thr Asp Gly Glu Asp Asn 
                405                 410                 415     


Thr Ile Ser Gly Cys Phe Asn Glu Val Lys Gln Ser Gly Ala Ile Ile 
            420                 425                 430         


His Thr Val Ala Leu Gly Pro Ser Ala Ala Gln Glu Leu Glu Glu Leu 
        435                 440                 445             


Ser Lys Met Thr Gly Gly Leu Gln Thr Tyr Ala Ser Asp Gln Val Gln 
    450                 455                 460                 


Asn Asn Gly Leu Ile Asp Ala Phe Gly Ala Leu Ser Ser Gly Asn Gly 
465                 470                 475                 480 


Ala Val Ser Gln Arg Ser Ile Gln Leu Glu Ser Lys Gly Leu Thr Leu 
                485                 490                 495     


Gln Asn Ser Gln Trp Met Asn Gly Thr Val Ile Val Asp Ser Thr Val 
            500                 505                 510         


Gly Lys Asp Thr Leu Phe Leu Ile Thr Trp Thr Met Gln Pro Pro Gln 
        515                 520                 525             


Ile Leu Leu Trp Asp Pro Ser Gly Gln Lys Gln Gly Gly Phe Val Val 
    530                 535                 540                 


Asp Lys Asn Thr Lys Met Ala Tyr Leu Gln Ile Pro Gly Ile Ala Lys 
545                 550                 555                 560 


Val Gly Thr Trp Lys Tyr Ser Leu Gln Ala Ser Ser Gln Thr Leu Thr 
                565                 570                 575     


Leu Thr Val Thr Ser Arg Ala Ser Asn Ala Thr Leu Pro Pro Ile Thr 
            580                 585                 590         


Val Thr Ser Lys Thr Asn Lys Asp Thr Ser Lys Phe Pro Ser Pro Leu 
        595                 600                 605             


Val Val Tyr Ala Asn Ile Arg Gln Gly Ala Ser Pro Ile Leu Arg Ala 
    610                 615                 620                 


Ser Val Thr Ala Leu Ile Glu Ser Val Asn Gly Lys Thr Val Thr Leu 
625                 630                 635                 640 


Glu Leu Leu Asp Asn Gly Ala Gly Ala Asp Ala Thr Lys Asp Asp Gly 
                645                 650                 655     


Val Tyr Ser Arg Tyr Phe Thr Thr Tyr Asp Thr Asn Gly Arg Tyr Ser 
            660                 665                 670         


Val Lys Val Arg Ala Leu Gly Gly Val Asn Ala Ala Arg Arg Arg Val 
        675                 680                 685             


Ile Pro Gln Gln Ser Gly Ala Leu Tyr Ile Pro Gly Trp Ile Glu Asn 
    690                 695                 700                 


Asp Glu Ile Gln Trp Asn Pro Pro Arg Pro Glu Ile Asn Lys Asp Asp 
705                 710                 715                 720 


Val Gln His Lys Gln Val Cys Phe Ser Arg Thr Ser Ser Gly Gly Ser 
                725                 730                 735     


Phe Val Ala Ser Asp Val Pro Asn Ala Pro Ile Pro Asp Leu Phe Pro 
            740                 745                 750         


Pro Gly Gln Ile Thr Asp Leu Lys Ala Glu Ile His Gly Gly Ser Leu 
        755                 760                 765             


Ile Asn Leu Thr Trp Thr Ala Pro Gly Asp Asp Tyr Asp His Gly Thr 
    770                 775                 780                 


Ala His Lys Tyr Ile Ile Arg Ile Ser Thr Ser Ile Leu Asp Leu Arg 
785                 790                 795                 800 


Asp Lys Phe Asn Glu Ser Leu Gln Val Asn Thr Thr Ala Leu Ile Pro 
                805                 810                 815     


Lys Glu Ala Asn Ser Glu Glu Val Phe Leu Phe Lys Pro Glu Asn Ile 
            820                 825                 830         


Thr Phe Glu Asn Gly Thr Asp Leu Phe Ile Ala Ile Gln Ala Val Asp 
        835                 840                 845             


Lys Val Asp Leu Lys Ser Glu Ile Ser Asn Ile Ala Arg Val Ser Leu 
    850                 855                 860                 


Phe Ile Pro Pro Gln Thr Pro Pro Glu Thr Pro Ser Pro Asp Glu Thr 
865                 870                 875                 880 


Ser Ala Pro Cys Pro Asn Ile His Ile Asn Ser Thr Ile Pro Gly Ile 
                885                 890                 895     


His Ile Leu Lys Ile Met Trp Lys Trp Ile Gly Glu Leu Gln Leu Ser 
            900                 905                 910         


Ile Ala 
        


<210>  2955
<211>  914
<212>  PRT
<213>  Homo Sapiens

<400>  2955

Met Gly Pro Phe Lys Ser Ser Val Phe Ile Leu Ile Leu His Leu Leu 
1               5                   10                  15      


Glu Gly Ala Leu Ser Asn Ser Leu Ile Gln Leu Asn Asn Asn Gly Tyr 
            20                  25                  30          


Glu Gly Ile Val Val Ala Ile Asp Pro Asn Val Pro Glu Asp Glu Thr 
        35                  40                  45              


Leu Ile Gln Gln Ile Lys Asp Met Val Thr Gln Ala Ser Leu Tyr Leu 
    50                  55                  60                  


Leu Glu Ala Thr Gly Lys Arg Phe Tyr Phe Lys Asn Val Ala Ile Leu 
65                  70                  75                  80  


Ile Pro Glu Thr Trp Lys Thr Lys Ala Asp Tyr Val Arg Pro Lys Leu 
                85                  90                  95      


Glu Thr Tyr Lys Asn Ala Asp Val Leu Val Ala Glu Ser Thr Pro Pro 
            100                 105                 110         


Gly Asn Asp Glu Pro Tyr Thr Glu Gln Met Gly Asn Cys Gly Glu Lys 
        115                 120                 125             


Gly Glu Arg Ile His Leu Thr Pro Asp Phe Ile Ala Gly Lys Lys Leu 
    130                 135                 140                 


Ala Glu Tyr Gly Pro Gln Gly Arg Ala Phe Val His Glu Trp Ala His 
145                 150                 155                 160 


Leu Arg Trp Gly Val Phe Asp Glu Tyr Asn Asn Asp Glu Lys Phe Tyr 
                165                 170                 175     


Leu Ser Asn Gly Arg Ile Gln Ala Val Arg Cys Ser Ala Gly Ile Thr 
            180                 185                 190         


Gly Thr Asn Val Val Lys Lys Cys Gln Gly Gly Ser Cys Tyr Thr Lys 
        195                 200                 205             


Arg Cys Thr Phe Asn Lys Val Thr Gly Leu Tyr Glu Lys Gly Cys Glu 
    210                 215                 220                 


Phe Val Leu Gln Ser Arg Gln Thr Glu Lys Ala Ser Ile Met Phe Ala 
225                 230                 235                 240 


Gln His Val Asp Ser Ile Val Glu Phe Cys Thr Glu Gln Asn His Asn 
                245                 250                 255     


Lys Glu Ala Pro Asn Lys Gln Asn Gln Lys Cys Asn Leu Arg Ser Thr 
            260                 265                 270         


Trp Glu Val Ile Arg Asp Ser Glu Asp Phe Lys Lys Thr Thr Pro Met 
        275                 280                 285             


Thr Thr Gln Pro Pro Asn Pro Thr Phe Ser Leu Leu Gln Ile Gly Gln 
    290                 295                 300                 


Arg Ile Val Cys Leu Val Leu Asp Lys Ser Gly Ser Met Ala Thr Gly 
305                 310                 315                 320 


Asn Arg Leu Asn Arg Leu Asn Gln Ala Gly Gln Leu Phe Leu Leu Gln 
                325                 330                 335     


Thr Val Glu Leu Gly Ser Trp Val Gly Met Val Thr Phe Asp Ser Ala 
            340                 345                 350         


Ala His Val Gln Asn Glu Leu Ile Gln Ile Asn Ser Gly Ser Asp Arg 
        355                 360                 365             


Asp Thr Leu Ala Lys Arg Leu Pro Ala Ala Ala Ser Gly Gly Thr Ser 
    370                 375                 380                 


Ile Cys Ser Gly Leu Arg Ser Ala Phe Thr Val Ile Arg Lys Lys Tyr 
385                 390                 395                 400 


Pro Thr Asp Gly Ser Glu Ile Val Leu Leu Thr Asp Gly Glu Asp Asn 
                405                 410                 415     


Thr Ile Ser Gly Cys Phe Asn Glu Val Lys Gln Ser Gly Ala Ile Ile 
            420                 425                 430         


His Thr Val Ala Leu Gly Pro Ser Ala Ala Gln Glu Leu Glu Glu Leu 
        435                 440                 445             


Ser Lys Met Thr Gly Gly Leu Gln Thr Tyr Ala Ser Asp Gln Val Gln 
    450                 455                 460                 


Asn Asn Gly Leu Ile Asp Ala Phe Gly Ala Leu Ser Ser Gly Asn Gly 
465                 470                 475                 480 


Ala Val Ser Gln Arg Ser Ile Gln Leu Glu Ser Lys Gly Leu Thr Leu 
                485                 490                 495     


Gln Asn Ser Gln Trp Met Asn Gly Thr Val Ile Val Asp Ser Thr Val 
            500                 505                 510         


Gly Lys Asp Thr Leu Phe Leu Ile Thr Trp Thr Met Gln Pro Pro Gln 
        515                 520                 525             


Ile Leu Leu Trp Asp Pro Ser Gly Gln Lys Gln Gly Gly Phe Val Val 
    530                 535                 540                 


Asp Lys Asn Thr Lys Met Ala Tyr Leu Gln Ile Pro Gly Ile Ala Lys 
545                 550                 555                 560 


Val Gly Thr Trp Lys Tyr Ser Leu Gln Ala Ser Ser Gln Thr Leu Thr 
                565                 570                 575     


Leu Thr Val Thr Ser Arg Ala Ser Asn Ala Thr Leu Pro Pro Ile Thr 
            580                 585                 590         


Val Thr Ser Lys Thr Asn Lys Asp Thr Ser Lys Phe Pro Ser Pro Leu 
        595                 600                 605             


Val Val Tyr Ala Asn Ile Arg Gln Gly Ala Ser Pro Ile Leu Arg Ala 
    610                 615                 620                 


Ser Val Thr Ala Leu Ile Glu Ser Val Asn Gly Lys Thr Val Thr Leu 
625                 630                 635                 640 


Glu Leu Leu Asp Asn Gly Ala Gly Ala Asp Ala Thr Lys Asp Asp Gly 
                645                 650                 655     


Val Tyr Ser Arg Tyr Phe Thr Thr Tyr Asp Thr Asn Gly Arg Tyr Ser 
            660                 665                 670         


Val Lys Val Arg Ala Leu Gly Gly Val Asn Ala Ala Arg Arg Arg Val 
        675                 680                 685             


Ile Pro Gln Gln Ser Gly Ala Leu Tyr Ile Pro Gly Trp Ile Glu Asn 
    690                 695                 700                 


Asp Glu Ile Gln Trp Asn Pro Pro Arg Pro Glu Ile Asn Lys Asp Asp 
705                 710                 715                 720 


Val Gln His Lys Gln Val Cys Phe Ser Arg Thr Ser Ser Gly Gly Ser 
                725                 730                 735     


Phe Val Ala Ser Asp Val Pro Asn Ala Pro Ile Pro Asp Leu Phe Pro 
            740                 745                 750         


Pro Gly Gln Ile Thr Asp Leu Lys Ala Glu Ile His Gly Gly Ser Leu 
        755                 760                 765             


Ile Asn Leu Thr Trp Thr Ala Pro Gly Asp Asp Tyr Asp His Gly Thr 
    770                 775                 780                 


Ala His Lys Tyr Ile Ile Arg Ile Ser Thr Ser Ile Leu Asp Leu Arg 
785                 790                 795                 800 


Asp Lys Phe Asn Glu Ser Leu Gln Val Asn Thr Thr Ala Leu Ile Pro 
                805                 810                 815     


Lys Glu Ala Asn Ser Glu Glu Val Phe Leu Phe Lys Pro Glu Asn Ile 
            820                 825                 830         


Thr Phe Glu Asn Gly Thr Asp Leu Phe Ile Ala Ile Gln Ala Val Asp 
        835                 840                 845             


Lys Val Asp Leu Lys Ser Glu Ile Ser Asn Ile Ala Arg Val Ser Leu 
    850                 855                 860                 


Phe Ile Pro Pro Gln Thr Pro Pro Glu Thr Pro Ser Pro Asp Glu Thr 
865                 870                 875                 880 


Ser Ala Pro Cys Pro Asn Ile His Ile Asn Ser Thr Ile Pro Gly Ile 
                885                 890                 895     


His Ile Leu Lys Ile Met Trp Lys Trp Ile Gly Glu Leu Gln Leu Ser 
            900                 905                 910         


Ile Ala 
        


<210>  2956
<211>  225
<212>  PRT
<213>  Homo Sapiens

<400>  2956

Met Asp Leu Arg Ala Gly Asp Ser Trp Gly Met Leu Ala Cys Leu Cys 
1               5                   10                  15      


Thr Val Leu Trp His Leu Pro Ala Val Pro Ala Leu Asn Arg Thr Gly 
            20                  25                  30          


Asp Pro Gly Pro Gly Pro Ser Ile Gln Lys Thr Tyr Asp Leu Thr Arg 
        35                  40                  45              


Tyr Leu Glu His Gln Leu Arg Ser Leu Ala Gly Thr Tyr Leu Asn Tyr 
    50                  55                  60                  


Leu Gly Pro Pro Phe Asn Glu Pro Asp Phe Asn Pro Pro Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Thr Leu Pro Arg Ala Thr Val Asp Leu Glu Val Trp Arg Ser 
                85                  90                  95      


Leu Asn Asp Lys Leu Arg Leu Thr Gln Asn Tyr Glu Ala Tyr Ser His 
            100                 105                 110         


Leu Leu Cys Tyr Leu Arg Gly Leu Asn Arg Gln Ala Ala Thr Ala Glu 
        115                 120                 125             


Leu Arg Arg Ser Leu Ala His Phe Cys Thr Ser Leu Gln Gly Leu Leu 
    130                 135                 140                 


Gly Ser Ile Ala Gly Val Met Ala Ala Leu Gly Tyr Pro Leu Pro Gln 
145                 150                 155                 160 


Pro Leu Pro Gly Thr Glu Pro Thr Trp Thr Pro Gly Pro Ala His Ser 
                165                 170                 175     


Asp Phe Leu Gln Lys Met Asp Asp Phe Trp Leu Leu Lys Glu Leu Gln 
            180                 185                 190         


Thr Trp Leu Trp Arg Ser Ala Lys Asp Phe Asn Arg Leu Lys Lys Lys 
        195                 200                 205             


Met Gln Pro Pro Ala Ala Ala Val Thr Leu His Leu Gly Ala His Gly 
    210                 215                 220                 


Phe 
225 


<210>  2957
<211>  215
<212>  PRT
<213>  Homo Sapiens

<400>  2957

Met Leu Ala Cys Leu Cys Thr Val Leu Trp His Leu Pro Ala Val Pro 
1               5                   10                  15      


Ala Leu Asn Arg Thr Gly Asp Pro Gly Pro Gly Pro Ser Ile Gln Lys 
            20                  25                  30          


Thr Tyr Asp Leu Thr Arg Tyr Leu Glu His Gln Leu Arg Ser Leu Ala 
        35                  40                  45              


Gly Thr Tyr Leu Asn Tyr Leu Gly Pro Pro Phe Asn Glu Pro Asp Phe 
    50                  55                  60                  


Asn Pro Pro Arg Leu Gly Ala Glu Thr Leu Pro Arg Ala Thr Val Asp 
65                  70                  75                  80  


Leu Glu Val Trp Arg Ser Leu Asn Asp Lys Leu Arg Leu Thr Gln Asn 
                85                  90                  95      


Tyr Glu Ala Tyr Ser His Leu Leu Cys Tyr Leu Arg Gly Leu Asn Arg 
            100                 105                 110         


Gln Ala Ala Thr Ala Glu Leu Arg Arg Ser Leu Ala His Phe Cys Thr 
        115                 120                 125             


Ser Leu Gln Gly Leu Leu Gly Ser Ile Ala Gly Val Met Ala Ala Leu 
    130                 135                 140                 


Gly Tyr Pro Leu Pro Gln Pro Leu Pro Gly Thr Glu Pro Thr Trp Thr 
145                 150                 155                 160 


Pro Gly Pro Ala His Ser Asp Phe Leu Gln Lys Met Asp Asp Phe Trp 
                165                 170                 175     


Leu Leu Lys Glu Leu Gln Thr Trp Leu Trp Arg Ser Ala Lys Asp Phe 
            180                 185                 190         


Asn Arg Leu Lys Lys Lys Met Gln Pro Pro Ala Ala Ala Val Thr Leu 
        195                 200                 205             


His Leu Gly Ala His Gly Phe 
    210                 215 


<210>  2958
<211>  170
<212>  PRT
<213>  Homo Sapiens

<400>  2958

Met Ser Met Ala Val Glu Thr Phe Gly Phe Phe Met Ala Thr Val Gly 
1               5                   10                  15      


Leu Leu Met Leu Gly Val Thr Leu Pro Asn Ser Tyr Trp Arg Val Ser 
            20                  25                  30          


Thr Val His Gly Asn Val Ile Thr Thr Asn Thr Ile Phe Glu Asn Leu 
        35                  40                  45              


Trp Phe Ser Cys Ala Thr Asp Ser Leu Gly Val Tyr Asn Cys Trp Glu 
    50                  55                  60                  


Phe Pro Ser Met Leu Ala Leu Ser Gly Ile Ala Gly Leu Arg Cys Thr 
65                  70                  75                  80  


Asn Ile Gly Gly Leu Glu Leu Ser Arg Lys Ala Lys Leu Ala Ala Thr 
                85                  90                  95      


Ala Gly Ala Leu His Ile Leu Ala Gly Ile Cys Gly Met Val Ala Ile 
            100                 105                 110         


Ser Trp Tyr Ala Phe Asn Ile Thr Arg Asp Phe Phe Asp Pro Leu Tyr 
        115                 120                 125             


Pro Gly Thr Lys Tyr Glu Leu Gly Pro Ala Leu Tyr Leu Gly Trp Ser 
    130                 135                 140                 


Ala Ser Leu Ile Ser Ile Leu Gly Gly Leu Cys Leu Cys Ser Ala Cys 
145                 150                 155                 160 


Cys Cys Gly Ser Asp Glu Asp Pro Ala Ala 
                165                 170 


<210>  2959
<211>  148
<212>  PRT
<213>  Homo Sapiens

<400>  2959

Met Ser Met Ala Val Glu Thr Phe Gly Phe Phe Met Ala Thr Val Gly 
1               5                   10                  15      


Leu Leu Met Leu Gly Val Thr Leu Pro Asn Ser Tyr Trp Arg Val Ser 
            20                  25                  30          


Thr Val His Gly Asn Val Ile Thr Thr Asn Thr Ile Phe Glu Asn Leu 
        35                  40                  45              


Trp Phe Ser Cys Ala Thr Asp Ser Leu Gly Val Tyr Asn Cys Trp Glu 
    50                  55                  60                  


Phe Pro Ser Met Leu Ala Leu Ser Gly Ile Cys Gly Met Val Ala Ile 
65                  70                  75                  80  


Ser Trp Tyr Ala Phe Asn Ile Thr Arg Asp Phe Phe Asp Pro Leu Tyr 
                85                  90                  95      


Pro Gly Thr Lys Tyr Glu Leu Gly Pro Ala Leu Tyr Leu Gly Trp Ser 
            100                 105                 110         


Ala Ser Leu Ile Ser Ile Leu Gly Gly Leu Cys Leu Cys Ser Ala Cys 
        115                 120                 125             


Cys Cys Gly Ser Asp Glu Asp Pro Ala Ala Ser Ala Arg Arg Pro Tyr 
    130                 135                 140                 


Gln Ala Pro Val 
145             


<210>  2960
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  2960

Met Ser Met Ala Val Glu Thr Phe Gly Phe Phe Met Ala Thr Val Gly 
1               5                   10                  15      


Leu Leu Met Leu Gly Val Thr Leu Pro Asn Ser Tyr Trp Arg Val Ser 
            20                  25                  30          


Thr Val His Gly Asn Val Ile Thr Thr Asn Thr Ile Phe Glu Asn Leu 
        35                  40                  45              


Trp Phe Ser Cys Ala Thr Asp Ser Leu Gly Val Tyr Asn Cys Trp Glu 
    50                  55                  60                  


Phe Pro Ser Met Leu Ala Leu Ser Gly Ser Thr Asp Ser Pro Ala Ser 
65                  70                  75                  80  


Leu Ser Gly Gly Thr Gly Leu Leu Val Arg Leu Met Ser Ile Lys Gly 
                85                  90                  95      


Pro Cys Glu Gly Arg Arg Leu Ala Ser Cys Arg Leu Ser Val Arg Cys 
            100                 105                 110         


Lys Glu Ala Val Cys Val Gln Gly Ile Phe Arg Pro Ala Gly His Ser 
        115                 120                 125             


<210>  2961
<211>  228
<212>  PRT
<213>  Homo Sapiens

<400>  2961

Met Ser Met Ala Val Glu Thr Phe Gly Phe Phe Met Ala Thr Val Gly 
1               5                   10                  15      


Leu Leu Met Leu Gly Val Thr Leu Pro Asn Ser Tyr Trp Arg Val Ser 
            20                  25                  30          


Thr Val His Gly Asn Val Ile Thr Thr Asn Thr Ile Phe Glu Asn Leu 
        35                  40                  45              


Trp Phe Ser Cys Ala Thr Asp Ser Leu Gly Val Tyr Asn Cys Trp Glu 
    50                  55                  60                  


Phe Pro Ser Met Leu Ala Leu Ser Gly Tyr Ile Gln Ala Cys Arg Ala 
65                  70                  75                  80  


Leu Met Ile Thr Ala Ile Leu Leu Gly Phe Leu Gly Leu Leu Leu Gly 
                85                  90                  95      


Ile Ala Gly Leu Arg Cys Thr Asn Ile Gly Gly Leu Glu Leu Ser Arg 
            100                 105                 110         


Lys Ala Lys Leu Ala Ala Thr Ala Gly Ala Leu His Ile Leu Ala Gly 
        115                 120                 125             


Ile Cys Gly Met Val Ala Ile Ser Trp Tyr Ala Phe Asn Ile Thr Arg 
    130                 135                 140                 


Asp Phe Phe Asp Pro Leu Tyr Pro Gly Thr Lys Tyr Glu Leu Gly Pro 
145                 150                 155                 160 


Ala Leu Tyr Leu Gly Trp Ser Ala Ser Leu Ile Ser Ile Leu Gly Gly 
                165                 170                 175     


Leu Cys Leu Cys Ser Ala Cys Cys Cys Gly Ser Asp Glu Asp Pro Ala 
            180                 185                 190         


Ala Ser Ala Arg Arg Pro Tyr Gln Ala Pro Val Ser Val Met Pro Val 
        195                 200                 205             


Ala Thr Ser Asp Gln Glu Gly Asp Ser Ser Phe Gly Lys Tyr Gly Arg 
    210                 215                 220                 


Asn Ala Tyr Val 
225             


<210>  2962
<211>  228
<212>  PRT
<213>  Homo Sapiens

<400>  2962

Met Ser Met Ala Val Glu Thr Phe Gly Phe Phe Met Ala Thr Val Gly 
1               5                   10                  15      


Leu Leu Met Leu Gly Val Thr Leu Pro Asn Ser Tyr Trp Arg Val Ser 
            20                  25                  30          


Thr Val His Gly Asn Val Ile Thr Thr Asn Thr Ile Phe Glu Asn Leu 
        35                  40                  45              


Trp Phe Ser Cys Ala Thr Asp Ser Leu Gly Val Tyr Asn Cys Trp Glu 
    50                  55                  60                  


Phe Pro Ser Met Leu Ala Leu Ser Gly Tyr Ile Gln Ala Cys Arg Ala 
65                  70                  75                  80  


Leu Met Ile Thr Ala Ile Leu Leu Gly Phe Leu Gly Leu Leu Leu Gly 
                85                  90                  95      


Ile Ala Gly Leu Arg Cys Thr Asn Ile Gly Gly Leu Glu Leu Ser Arg 
            100                 105                 110         


Lys Ala Lys Leu Ala Ala Thr Ala Gly Ala Leu His Ile Leu Ala Gly 
        115                 120                 125             


Ile Cys Gly Met Val Ala Ile Ser Trp Tyr Ala Phe Asn Ile Thr Arg 
    130                 135                 140                 


Asp Phe Phe Asp Pro Leu Tyr Pro Gly Thr Lys Tyr Glu Leu Gly Pro 
145                 150                 155                 160 


Ala Leu Tyr Leu Gly Trp Ser Ala Ser Leu Ile Ser Ile Leu Gly Gly 
                165                 170                 175     


Leu Cys Leu Cys Ser Ala Cys Cys Cys Gly Ser Asp Glu Asp Pro Ala 
            180                 185                 190         


Ala Ser Ala Arg Arg Pro Tyr Gln Ala Pro Val Ser Val Met Pro Val 
        195                 200                 205             


Ala Thr Ser Asp Gln Glu Gly Asp Ser Ser Phe Gly Lys Tyr Gly Arg 
    210                 215                 220                 


Asn Ala Tyr Val 
225             


<210>  2963
<211>  106
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  2963

Xaa Gly Asn Val Ile Thr Thr Asn Thr Ile Phe Glu Asn Leu Trp Phe 
1               5                   10                  15      


Ser Cys Ala Thr Asp Ser Leu Gly Val Tyr Asn Cys Trp Glu Phe Pro 
            20                  25                  30          


Ser Met Leu Ala Leu Ser Gly Tyr Ile Gln Ala Cys Arg Ala Leu Met 
        35                  40                  45              


Ile Thr Ala Ile Leu Leu Gly Phe Leu Gly Leu Leu Leu Gly Ile Ala 
    50                  55                  60                  


Gly Leu Arg Cys Thr Asn Ile Gly Gly Leu Glu Leu Ser Arg Lys Ala 
65                  70                  75                  80  


Lys Leu Ala Ala Thr Ala Gly Ala Leu His Ile Leu Ala Asp Leu Leu 
                85                  90                  95      


Ala Ala Asn Gln Pro Ile Gly Ser Val Ser 
            100                 105     


<210>  2964
<211>  140
<212>  PRT
<213>  Homo Sapiens

<400>  2964

Met Ala Asn Ser Gly Leu Gln Leu Leu Gly Phe Ser Met Ala Leu Leu 
1               5                   10                  15      


Gly Trp Val Gly Leu Val Ala Cys Thr Ala Ile Pro Gln Trp Gln Met 
            20                  25                  30          


Ser Ser Tyr Ala Gly Asp Asn Ile Ile Thr Ala Gln Ala Met Tyr Lys 
        35                  40                  45              


Gly Leu Trp Met Asp Cys Val Thr Gln Ser Thr Gly Met Met Ser Cys 
    50                  55                  60                  


Lys Ile Gly Leu Ala Gly His Ser Ser Pro Asn Gly Gly Leu Pro Gly 
65                  70                  75                  80  


Ala Gly Leu Pro Gly His Val Cys Gly His Asp Gly His Glu Val His 
                85                  90                  95      


Ala Leu Trp Gly Arg Arg Gln Ser Glu Glu Gly Pro Tyr Ser His Gly 
            100                 105                 110         


Trp Arg His Asn Phe His Arg Gly Arg Ser Cys Arg Leu Gly Ser Leu 
        115                 120                 125             


Leu Leu Val Trp Pro Ser Asp Cys His Arg Leu Leu 
    130                 135                 140 


<210>  2965
<211>  129
<212>  PRT
<213>  Homo Sapiens

<400>  2965

Met Ala Asn Ser Gly Leu Gln Leu Leu Gly Phe Ser Met Ala Leu Leu 
1               5                   10                  15      


Gly Trp Val Gly Leu Val Ala Cys Thr Ala Ile Pro Gln Trp Gln Met 
            20                  25                  30          


Ser Ser Tyr Ala Gly Asp Asn Ile Ile Thr Ala Gln Ala Met Tyr Lys 
        35                  40                  45              


Gly Leu Trp Met Asp Cys Val Thr Gln Ser Thr Gly Met Met Ser Cys 
    50                  55                  60                  


Lys Met Tyr Asp Ser Val Leu Ala Leu Ser Ala Ala Leu Gln Ala Thr 
65                  70                  75                  80  


Arg Ala Leu Met Val Val Ser Leu Val Leu Gly Phe Leu Ala Met Phe 
                85                  90                  95      


Val Ala Thr Met Gly Met Lys Cys Thr Arg Cys Gly Gly Asp Asp Lys 
            100                 105                 110         


Val Lys Lys Ala Arg Ile Ala Met Gly Gly Gly Ile Ile Phe Ile Val 
        115                 120                 125             


Ala 
    


<210>  2966
<211>  211
<212>  PRT
<213>  Homo Sapiens

<400>  2966

Met Ala Asn Ser Gly Leu Gln Leu Leu Gly Phe Ser Met Ala Leu Leu 
1               5                   10                  15      


Gly Trp Val Gly Leu Val Ala Cys Thr Ala Ile Pro Gln Trp Gln Met 
            20                  25                  30          


Ser Ser Tyr Ala Gly Asp Asn Ile Ile Thr Ala Gln Ala Met Tyr Lys 
        35                  40                  45              


Gly Leu Trp Met Asp Cys Val Thr Gln Ser Thr Gly Met Met Ser Cys 
    50                  55                  60                  


Lys Met Tyr Asp Ser Val Leu Ala Leu Ser Ala Ala Leu Gln Ala Thr 
65                  70                  75                  80  


Arg Ala Leu Met Val Val Ser Leu Val Leu Gly Phe Leu Ala Met Phe 
                85                  90                  95      


Val Ala Thr Met Gly Met Lys Cys Thr Arg Cys Gly Gly Asp Asp Lys 
            100                 105                 110         


Val Lys Lys Ala Arg Ile Ala Met Gly Gly Gly Ile Ile Phe Ile Val 
        115                 120                 125             


Ala Gly Leu Ala Ala Leu Val Ala Cys Ser Trp Tyr Gly His Gln Ile 
    130                 135                 140                 


Val Thr Asp Phe Tyr Asn Pro Leu Ile Pro Thr Asn Ile Lys Tyr Glu 
145                 150                 155                 160 


Phe Gly Pro Ala Ile Phe Ile Gly Trp Ala Gly Ser Ala Leu Val Ile 
                165                 170                 175     


Leu Gly Gly Ala Leu Leu Ser Cys Ser Cys Pro Gly Asn Glu Ser Lys 
            180                 185                 190         


Ala Gly Tyr Arg Val Pro Arg Ser Tyr Pro Lys Ser Asn Ser Ser Lys 
        195                 200                 205             


Glu Tyr Val 
    210     


<210>  2967
<211>  211
<212>  PRT
<213>  Homo Sapiens

<400>  2967

Met Ala Asn Ser Gly Leu Gln Leu Leu Gly Phe Ser Met Ala Leu Leu 
1               5                   10                  15      


Gly Trp Val Gly Leu Val Ala Cys Thr Ala Ile Pro Gln Trp Gln Met 
            20                  25                  30          


Ser Ser Tyr Ala Gly Asp Asn Ile Ile Thr Ala Gln Ala Met Tyr Lys 
        35                  40                  45              


Gly Leu Trp Met Asp Cys Val Thr Gln Ser Thr Gly Met Met Ser Cys 
    50                  55                  60                  


Lys Met Tyr Asp Ser Val Leu Ala Leu Ser Ala Ala Leu Gln Ala Thr 
65                  70                  75                  80  


Arg Ala Leu Met Val Val Ser Leu Val Leu Gly Phe Leu Ala Met Phe 
                85                  90                  95      


Val Ala Thr Met Gly Met Lys Cys Thr Arg Cys Gly Gly Asp Asp Lys 
            100                 105                 110         


Val Lys Lys Ala Arg Ile Ala Met Gly Gly Gly Ile Ile Phe Ile Val 
        115                 120                 125             


Ala Gly Leu Ala Ala Leu Val Ala Cys Ser Trp Tyr Gly His Gln Ile 
    130                 135                 140                 


Val Thr Asp Phe Tyr Asn Pro Leu Ile Pro Thr Asn Ile Lys Tyr Glu 
145                 150                 155                 160 


Phe Gly Pro Ala Ile Phe Ile Gly Trp Ala Gly Ser Ala Leu Val Ile 
                165                 170                 175     


Leu Gly Gly Ala Leu Leu Ser Cys Ser Cys Pro Gly Asn Glu Ser Lys 
            180                 185                 190         


Ala Gly Tyr Arg Val Pro Arg Ser Tyr Pro Lys Ser Asn Ser Ser Lys 
        195                 200                 205             


Glu Tyr Val 
    210     


<210>  2968
<211>  145
<212>  PRT
<213>  Homo Sapiens

<400>  2968

Met Ala Asn Ser Gly Leu Gln Leu Leu Gly Phe Ser Met Ala Leu Leu 
1               5                   10                  15      


Gly Trp Val Gly Leu Val Ala Cys Thr Ala Ile Pro Gln Trp Gln Met 
            20                  25                  30          


Ser Ser Tyr Ala Gly Asp Asn Ile Ile Thr Ala Gln Ala Met Tyr Lys 
        35                  40                  45              


Gly Leu Trp Met Asp Cys Val Thr Gln Ser Thr Gly Met Met Ser Cys 
    50                  55                  60                  


Lys Met Tyr Asp Ser Val Leu Ala Leu Ser Ala Ala Leu Gln Ala Thr 
65                  70                  75                  80  


Arg Ala Leu Met Val Val Ser Leu Val Leu Gly Phe Leu Ala Met Phe 
                85                  90                  95      


Val Ala Thr Met Gly Met Lys Cys Thr Arg Cys Gly Gly Asp Asp Lys 
            100                 105                 110         


Val Lys Lys Ala Arg Ile Ala Met Gly Gly Gly Ile Ile Phe Ile Val 
        115                 120                 125             


Ala Gly Met Ser Leu Ala Leu Pro Ser Leu Leu Ala Gly Gln Gly Leu 
    130                 135                 140                 


Pro 
145 


<210>  2969
<211>  194
<212>  PRT
<213>  Homo Sapiens

<400>  2969

Met Pro Glu Gly Thr Val Gly Leu Pro Ala Arg Arg Pro Gln Cys Phe 
1               5                   10                  15      


Leu Arg Ala Glu Met Ala Asn Ser Gly Leu Gln Leu Leu Gly Phe Ser 
            20                  25                  30          


Met Ala Leu Leu Gly Trp Val Gly Leu Val Ala Cys Thr Ala Ile Pro 
        35                  40                  45              


Gln Trp Gln Met Ser Ser Tyr Ala Gly Asp Asn Ile Ile Thr Ala Gln 
    50                  55                  60                  


Ala Met Tyr Lys Gly Leu Trp Met Asp Cys Val Thr Gln Ser Thr Gly 
65                  70                  75                  80  


Met Met Ser Cys Lys Met Tyr Asp Ser Val Leu Ala Leu Ser Ala Ala 
                85                  90                  95      


Leu Gln Ala Thr Arg Ala Leu Met Val Val Ser Leu Val Leu Gly Phe 
            100                 105                 110         


Leu Ala Met Phe Val Ala Thr Met Gly Met Lys Cys Thr Arg Cys Gly 
        115                 120                 125             


Gly Asp Asp Lys Val Lys Lys Ala Arg Ile Ala Met Gly Gly Gly Ile 
    130                 135                 140                 


Ile Phe Ile Val Ala Gly Leu Ala Ala Leu Val Ala Cys Ser Trp Tyr 
145                 150                 155                 160 


Gly His Gln Ile Val Thr Asp Phe Tyr Asn Pro Leu Ile Pro Thr Asn 
                165                 170                 175     


Ile Lys Tyr Glu Phe Gly Pro Ala Ile Phe Ile Gly Trp Ala Gly Ser 
            180                 185                 190         


Ala Leu 
        


<210>  2970
<211>  100
<212>  PRT
<213>  Homo Sapiens

<400>  2970

Met Val Val Ser Leu Val Leu Gly Phe Leu Ala Met Phe Val Ala Thr 
1               5                   10                  15      


Met Gly Met Lys Cys Thr Arg Cys Gly Gly Asp Asp Lys Val Lys Lys 
            20                  25                  30          


Ala Arg Ile Ala Met Gly Gly Gly Ile Ile Phe Ile Val Ala Gly Leu 
        35                  40                  45              


Ala Ala Leu Val Ala Cys Ser Trp Tyr Gly His Gln Ile Val Thr Asp 
    50                  55                  60                  


Phe Tyr Asn Pro Leu Ile Pro Thr Asn Ile Lys Tyr Glu Phe Gly Pro 
65                  70                  75                  80  


Ala Ile Phe Ile Gly Trp Ala Gly Ser Ala Leu Val Ile Leu Gly Gly 
                85                  90                  95      


Ala Leu Leu Ser 
            100 


<210>  2971
<211>  72
<212>  PRT
<213>  Homo Sapiens

<400>  2971

Phe Val Ser Leu Gly Leu Met Cys Phe Gly Ala Leu Ile Gly Leu Cys 
1               5                   10                  15      


Ala Cys Ile Cys Arg Ser Leu Tyr Pro Thr Ile Ala Thr Gly Ile Leu 
            20                  25                  30          


His Leu Leu Ala Gly Leu Cys Thr Leu Gly Ser Val Ser Cys Tyr Val 
        35                  40                  45              


Ala Gly Ile Glu Leu Leu His Gln Lys Leu Glu Leu Pro Asp Asn Pro 
    50                  55                  60                  


Ser Thr Ile Lys Asn Val Ser Pro 
65                  70          


<210>  2972
<211>  155
<212>  PRT
<213>  Homo Sapiens

<400>  2972

Lys Ser Ile Trp Asp Glu Phe Ile Ser Asp Glu Ala Asp Glu Lys Thr 
1               5                   10                  15      


Tyr Asn Asp Ala Leu Phe Arg Tyr Asn Gly Thr Val Gly Leu Trp Arg 
            20                  25                  30          


Arg Cys Ile Thr Ile Pro Lys Asn Met His Trp Tyr Ser Pro Pro Glu 
        35                  40                  45              


Arg Thr Glu Ser Phe Asp Val Val Thr Lys Cys Val Ser Phe Thr Leu 
    50                  55                  60                  


Thr Glu Gln Phe Met Glu Lys Phe Val Asp Pro Gly Asn His Asn Ser 
65                  70                  75                  80  


Gly Ile Asp Leu Leu Arg Thr Tyr Leu Trp Arg Cys Gln Phe Leu Leu 
                85                  90                  95      


Pro Phe Val Ser Leu Gly Leu Met Cys Phe Gly Ala Leu Ile Gly Leu 
            100                 105                 110         


Cys Ala Cys Ile Cys Arg Ser Leu Tyr Pro Thr Ile Ala Thr Gly Ile 
        115                 120                 125             


Leu His Leu Leu Ala Ala Gln Tyr Tyr Lys Glu Arg Phe Thr Ile Met 
    130                 135                 140                 


Thr Leu Gln Ser Trp Glu Thr Tyr His Lys Ile 
145                 150                 155 


<210>  2973
<211>  138
<212>  PRT
<213>  Homo Sapiens

<400>  2973

Met Ala Ala Ser Ile Gly Thr Asp Phe Trp Tyr Glu Tyr Arg Ser Pro 
1               5                   10                  15      


Val Gln Glu Asn Ser Ser Asp Leu Asn Lys Ser Ile Trp Asp Glu Phe 
            20                  25                  30          


Ile Ser Asp Glu Ala Asp Glu Lys Thr Tyr Asn Asp Ala Leu Phe Arg 
        35                  40                  45              


Tyr Asn Gly Thr Val Gly Leu Trp Arg Arg Cys Ile Thr Ile Pro Lys 
    50                  55                  60                  


Asn Met His Trp Tyr Ser Pro Pro Glu Arg Thr Glu Ser Phe Asp Val 
65                  70                  75                  80  


Val Thr Lys Cys Val Ser Phe Thr Leu Thr Glu Gln Phe Met Glu Lys 
                85                  90                  95      


Phe Val Asp Pro Gly Asn His Asn Ser Gly Ile Asp Leu Leu Arg Thr 
            100                 105                 110         


Tyr Leu Trp Arg Cys Gln Phe Leu Leu Pro Phe Val Ser Leu Gly Leu 
        115                 120                 125             


Met Cys Phe Gly Ala Leu Ile Gly Leu Cys 
    130                 135             


<210>  2974
<211>  223
<212>  PRT
<213>  Homo Sapiens

<400>  2974

Met Ala Ala Ser Ile Gly Thr Asp Phe Trp Tyr Glu Tyr Arg Ser Pro 
1               5                   10                  15      


Val Gln Glu Asn Ser Ser Asp Leu Asn Lys Ser Ile Trp Asp Glu Phe 
            20                  25                  30          


Ile Ser Asp Glu Ala Asp Glu Lys Thr Tyr Asn Asp Ala Leu Phe Arg 
        35                  40                  45              


Tyr Asn Gly Thr Val Gly Leu Trp Arg Arg Cys Ile Thr Ile Pro Lys 
    50                  55                  60                  


Asn Met His Trp Tyr Ser Pro Pro Glu Arg Thr Glu Ser Phe Asp Val 
65                  70                  75                  80  


Val Thr Lys Cys Val Ser Phe Thr Leu Thr Glu Gln Phe Met Glu Lys 
                85                  90                  95      


Phe Val Asp Pro Gly Asn His Asn Ser Gly Ile Asp Leu Leu Arg Thr 
            100                 105                 110         


Tyr Leu Trp Arg Cys Gln Phe Leu Leu Pro Phe Val Ser Leu Gly Leu 
        115                 120                 125             


Met Cys Phe Gly Ala Leu Ile Gly Leu Cys Ala Cys Ile Cys Arg Ser 
    130                 135                 140                 


Leu Tyr Pro Thr Ile Ala Thr Gly Ile Leu His Leu Leu Ala Gly Leu 
145                 150                 155                 160 


Cys Thr Leu Gly Ser Val Ser Cys Tyr Val Ala Gly Ile Glu Leu Leu 
                165                 170                 175     


His Gln Lys Leu Glu Leu Pro Asp Asn Val Ser Gly Glu Phe Gly Trp 
            180                 185                 190         


Ser Phe Cys Leu Ala Cys Val Ser Ala Pro Leu Gln Phe Met Ala Ser 
        195                 200                 205             


Ala Leu Phe Ile Trp Ala Ala His Thr Asn Arg Lys Glu Tyr Thr 
    210                 215                 220             


<210>  2975
<211>  89
<212>  PRT
<213>  Homo Sapiens

<400>  2975

Met Asp Asn Arg Phe Ala Thr Ala Phe Val Ile Ala Cys Val Leu Ser 
1               5                   10                  15      


Leu Ile Ser Thr Ile Tyr Met Ala Ala Ser Ile Gly Thr Asp Phe Trp 
            20                  25                  30          


Tyr Glu Tyr Arg Ser Pro Val Gln Glu Asn Ser Ser Asp Leu Asn Lys 
        35                  40                  45              


Ser Ile Trp Asp Glu Phe Ile Ser Asp Glu Ala Asp Glu Lys Thr Tyr 
    50                  55                  60                  


Asn Asp Ala Leu Phe Arg Tyr Asn Gly Thr Val Gly Leu Trp Arg Arg 
65                  70                  75                  80  


Cys Ile Thr Ile Pro Lys Asn Met His 
                85                  


<210>  2976
<211>  145
<212>  PRT
<213>  Homo Sapiens

<400>  2976

Met Asp Asn Arg Phe Ala Thr Ala Phe Val Ile Ala Cys Val Leu Ser 
1               5                   10                  15      


Leu Ile Ser Thr Ile Tyr Met Ala Ala Ser Ile Gly Thr Asp Phe Trp 
            20                  25                  30          


Tyr Glu Tyr Arg Ser Pro Val Gln Glu Asn Ser Ser Asp Leu Asn Lys 
        35                  40                  45              


Ser Ile Trp Asp Glu Phe Ile Ser Asp Glu Ala Asp Glu Lys Thr Tyr 
    50                  55                  60                  


Asn Asp Ala Leu Phe Arg Tyr Asn Gly Thr Val Gly Leu Trp Arg Arg 
65                  70                  75                  80  


Cys Ile Thr Ile Pro Lys Asn Met His Trp Tyr Ser Pro Pro Glu Arg 
                85                  90                  95      


Thr Glu Ser Phe Asp Val Val Thr Lys Cys Val Ser Phe Thr Leu Thr 
            100                 105                 110         


Glu Gln Phe Met Glu Lys Phe Val Asp Pro Gly Asn His Asn Ser Gly 
        115                 120                 125             


Ile Asp Leu Leu Arg Thr Tyr Leu Trp Arg Cys Gln Phe Leu Leu Pro 
    130                 135                 140                 


Phe 
145 


<210>  2977
<211>  172
<212>  PRT
<213>  Homo Sapiens

<400>  2977

Met Asp Asn Arg Phe Ala Thr Ala Phe Val Ile Ala Cys Val Leu Ser 
1               5                   10                  15      


Leu Ile Ser Thr Ile Tyr Met Ala Ala Ser Ile Gly Thr Asp Phe Trp 
            20                  25                  30          


Tyr Glu Tyr Arg Ser Pro Val Gln Glu Asn Ser Ser Asp Leu Asn Lys 
        35                  40                  45              


Ser Ile Trp Asp Glu Phe Ile Ser Asp Glu Ala Asp Glu Lys Thr Tyr 
    50                  55                  60                  


Asn Asp Ala Leu Phe Arg Tyr Asn Gly Thr Val Gly Leu Trp Arg Arg 
65                  70                  75                  80  


Cys Ile Thr Ile Pro Lys Asn Met His Trp Tyr Ser Pro Pro Glu Arg 
                85                  90                  95      


Thr Glu Ser Phe Asp Val Val Thr Lys Cys Val Ser Phe Thr Leu Thr 
            100                 105                 110         


Glu Gln Phe Met Glu Lys Phe Val Asp Pro Gly Asn His Asn Ser Gly 
        115                 120                 125             


Ile Asp Leu Leu Arg Thr Tyr Leu Trp Arg Cys Gln Phe Leu Leu Pro 
    130                 135                 140                 


Phe Val Ser Leu Gly Leu Met Cys Phe Gly Ala Leu Ile Gly Leu Cys 
145                 150                 155                 160 


Ala Cys Ile Cys Arg Ser Leu Tyr Pro Thr Ile Ala 
                165                 170         


<210>  2978
<211>  177
<212>  PRT
<213>  Homo Sapiens

<400>  2978

Met Asp Asn Arg Phe Ala Thr Ala Phe Val Ile Ala Cys Val Leu Ser 
1               5                   10                  15      


Leu Ile Ser Thr Ile Tyr Met Ala Ala Ser Ile Gly Thr Asp Phe Trp 
            20                  25                  30          


Tyr Glu Tyr Arg Ser Pro Val Gln Glu Asn Ser Ser Asp Leu Asn Lys 
        35                  40                  45              


Ser Ile Trp Asp Glu Phe Ile Ser Asp Glu Ala Asp Glu Lys Thr Tyr 
    50                  55                  60                  


Asn Asp Ala Leu Phe Arg Tyr Asn Gly Thr Val Gly Leu Trp Arg Arg 
65                  70                  75                  80  


Cys Ile Thr Ile Pro Lys Asn Met His Trp Tyr Ser Pro Pro Glu Arg 
                85                  90                  95      


Thr Glu Ser Phe Asp Val Val Thr Lys Cys Val Ser Phe Thr Leu Thr 
            100                 105                 110         


Glu Gln Phe Met Glu Lys Phe Val Asp Pro Gly Asn His Asn Ser Gly 
        115                 120                 125             


Ile Asp Leu Leu Arg Thr Tyr Leu Trp Arg Cys Gln Phe Leu Leu Pro 
    130                 135                 140                 


Phe Val Ser Leu Gly Leu Met Cys Phe Gly Ala Leu Ile Gly Leu Cys 
145                 150                 155                 160 


Ala Cys Ile Cys Arg Ser Leu Tyr Pro Thr Ile Ala Thr Gly Ile Leu 
                165                 170                 175     


His 
    


<210>  2979
<211>  180
<212>  PRT
<213>  Homo Sapiens

<400>  2979

Met Asp Asn Arg Phe Ala Thr Ala Phe Val Ile Ala Cys Val Leu Ser 
1               5                   10                  15      


Leu Ile Ser Thr Ile Tyr Met Ala Ala Ser Ile Gly Thr Asp Phe Trp 
            20                  25                  30          


Tyr Glu Tyr Arg Ser Pro Val Gln Glu Asn Ser Ser Asp Leu Asn Lys 
        35                  40                  45              


Ser Ile Trp Asp Glu Phe Ile Ser Asp Glu Ala Asp Glu Lys Thr Tyr 
    50                  55                  60                  


Asn Asp Ala Leu Phe Arg Tyr Asn Gly Thr Val Gly Leu Trp Arg Arg 
65                  70                  75                  80  


Cys Ile Thr Ile Pro Lys Asn Met His Trp Tyr Ser Pro Pro Glu Arg 
                85                  90                  95      


Thr Glu Ser Phe Asp Val Val Thr Lys Cys Val Ser Phe Thr Leu Thr 
            100                 105                 110         


Glu Gln Phe Met Glu Lys Phe Val Asp Pro Gly Asn His Asn Ser Gly 
        115                 120                 125             


Ile Asp Leu Leu Arg Thr Tyr Leu Trp Arg Cys Gln Phe Leu Leu Pro 
    130                 135                 140                 


Phe Val Ser Leu Gly Leu Met Cys Phe Gly Ala Leu Ile Gly Leu Cys 
145                 150                 155                 160 


Ala Cys Ile Cys Arg Ser Leu Tyr Pro Thr Ile Ala Thr Gly Ile Leu 
                165                 170                 175     


His Leu Leu Ala 
            180 


<210>  2980
<211>  213
<212>  PRT
<213>  Homo Sapiens

<400>  2980

Met Asp Asn Arg Phe Ala Thr Ala Phe Val Ile Ala Cys Val Leu Ser 
1               5                   10                  15      


Leu Ile Ser Thr Ile Tyr Met Ala Ala Ser Ile Gly Thr Asp Phe Trp 
            20                  25                  30          


Tyr Glu Tyr Arg Ser Pro Val Gln Glu Asn Ser Ser Asp Leu Asn Lys 
        35                  40                  45              


Ser Ile Trp Asp Glu Phe Ile Ser Asp Glu Ala Asp Glu Lys Thr Tyr 
    50                  55                  60                  


Asn Asp Ala Leu Phe Arg Tyr Asn Gly Thr Val Gly Leu Trp Arg Arg 
65                  70                  75                  80  


Cys Ile Thr Ile Pro Lys Asn Met His Trp Tyr Ser Pro Pro Glu Arg 
                85                  90                  95      


Thr Glu Ser Phe Asp Val Val Thr Lys Cys Val Ser Phe Thr Leu Thr 
            100                 105                 110         


Glu Gln Phe Met Glu Lys Phe Val Asp Pro Gly Asn His Asn Ser Gly 
        115                 120                 125             


Ile Asp Leu Leu Arg Thr Tyr Leu Trp Arg Cys Gln Phe Leu Leu Pro 
    130                 135                 140                 


Phe Val Ser Leu Gly Leu Met Cys Phe Gly Ala Leu Ile Gly Leu Cys 
145                 150                 155                 160 


Ala Cys Ile Cys Arg Ser Leu Tyr Pro Thr Ile Ala Thr Gly Ile Leu 
                165                 170                 175     


His Leu Leu Ala Gly Leu Cys Thr Leu Gly Ser Val Ser Cys Tyr Val 
            180                 185                 190         


Ala Gly Ile Glu Leu Leu His Gln Lys Leu Glu Leu Pro Asp Asn Val 
        195                 200                 205             


Ser Gly Glu Phe Gly 
    210             


<210>  2981
<211>  237
<212>  PRT
<213>  Homo Sapiens

<400>  2981

Met Asp Asn Arg Phe Ala Thr Ala Phe Val Ile Ala Cys Val Leu Ser 
1               5                   10                  15      


Leu Ile Ser Thr Ile Tyr Met Ala Ala Ser Ile Gly Thr Asp Phe Trp 
            20                  25                  30          


Tyr Glu Tyr Arg Ser Pro Val Gln Glu Asn Ser Ser Asp Leu Asn Lys 
        35                  40                  45              


Ser Ile Trp Asp Glu Phe Ile Ser Asp Glu Ala Asp Glu Lys Thr Tyr 
    50                  55                  60                  


Asn Asp Ala Leu Phe Arg Tyr Asn Gly Thr Val Gly Leu Trp Arg Arg 
65                  70                  75                  80  


Cys Ile Thr Ile Pro Lys Asn Met His Trp Tyr Ser Pro Pro Glu Arg 
                85                  90                  95      


Thr Glu Ser Phe Asp Val Val Thr Lys Cys Val Ser Phe Thr Leu Thr 
            100                 105                 110         


Glu Gln Phe Met Glu Lys Phe Val Asp Pro Gly Asn His Asn Ser Gly 
        115                 120                 125             


Ile Asp Leu Leu Arg Thr Tyr Leu Trp Arg Cys Gln Phe Leu Leu Pro 
    130                 135                 140                 


Phe Val Ser Leu Gly Leu Met Cys Phe Gly Ala Leu Ile Gly Leu Cys 
145                 150                 155                 160 


Ala Cys Ile Cys Arg Ser Leu Tyr Pro Thr Ile Ala Thr Gly Ile Leu 
                165                 170                 175     


His Leu Leu Ala Gly Leu Cys Thr Leu Gly Ser Val Ser Cys Tyr Val 
            180                 185                 190         


Ala Gly Ile Glu Leu Leu His Gln Lys Leu Glu Leu Pro Asp Asn Val 
        195                 200                 205             


Ser Gly Glu Phe Gly Trp Ser Phe Cys Leu Ala Cys Val Ser Ala Pro 
    210                 215                 220                 


Leu Gln Phe Met Ala Ser Ala Leu Phe Ile Trp Ala Ala 
225                 230                 235         


<210>  2982
<211>  239
<212>  PRT
<213>  Homo Sapiens

<400>  2982

Met Asp Asn Arg Phe Ala Thr Ala Phe Val Ile Ala Cys Val Leu Ser 
1               5                   10                  15      


Leu Ile Ser Thr Ile Tyr Met Ala Ala Ser Ile Gly Thr Asp Phe Trp 
            20                  25                  30          


Tyr Glu Tyr Arg Ser Pro Val Gln Glu Asn Ser Ser Asp Leu Asn Lys 
        35                  40                  45              


Ser Ile Trp Asp Glu Phe Ile Ser Asp Glu Ala Asp Glu Lys Thr Tyr 
    50                  55                  60                  


Asn Asp Ala Leu Phe Arg Tyr Asn Gly Thr Val Gly Leu Trp Arg Arg 
65                  70                  75                  80  


Cys Ile Thr Ile Pro Lys Asn Met His Trp Tyr Ser Pro Pro Glu Arg 
                85                  90                  95      


Thr Glu Ser Phe Asp Val Val Thr Lys Cys Val Ser Phe Thr Leu Thr 
            100                 105                 110         


Glu Gln Phe Met Glu Lys Phe Val Asp Pro Gly Asn His Asn Ser Gly 
        115                 120                 125             


Ile Asp Leu Leu Arg Thr Tyr Leu Trp Arg Cys Gln Phe Leu Leu Pro 
    130                 135                 140                 


Phe Val Ser Leu Gly Leu Met Cys Phe Gly Ala Leu Ile Gly Leu Cys 
145                 150                 155                 160 


Ala Cys Ile Cys Arg Ser Leu Tyr Pro Thr Ile Ala Thr Gly Ile Leu 
                165                 170                 175     


His Leu Leu Ala Gly Leu Cys Thr Leu Gly Ser Val Ser Cys Tyr Val 
            180                 185                 190         


Ala Gly Ile Glu Leu Leu His Gln Lys Leu Glu Leu Pro Asp Asn Val 
        195                 200                 205             


Ser Gly Glu Phe Gly Trp Ser Phe Cys Leu Ala Cys Val Ser Ala Pro 
    210                 215                 220                 


Leu Gln Phe Met Ala Ser Ala Leu Phe Ile Trp Ala Ala His Thr 
225                 230                 235                 


<210>  2983
<211>  245
<212>  PRT
<213>  Homo Sapiens

<400>  2983

Met Asp Asn Arg Phe Ala Thr Ala Phe Val Ile Ala Cys Val Leu Ser 
1               5                   10                  15      


Leu Ile Ser Thr Ile Tyr Met Ala Ala Ser Ile Gly Thr Asp Phe Trp 
            20                  25                  30          


Tyr Glu Tyr Arg Ser Pro Val Gln Glu Asn Ser Ser Asp Leu Asn Lys 
        35                  40                  45              


Ser Ile Trp Asp Glu Phe Ile Ser Asp Glu Ala Asp Glu Lys Thr Tyr 
    50                  55                  60                  


Asn Asp Ala Leu Phe Arg Tyr Asn Gly Thr Val Gly Leu Trp Arg Arg 
65                  70                  75                  80  


Cys Ile Thr Ile Pro Lys Asn Met His Trp Tyr Ser Pro Pro Glu Arg 
                85                  90                  95      


Thr Glu Ser Phe Asp Val Val Thr Lys Cys Val Ser Phe Thr Leu Thr 
            100                 105                 110         


Glu Gln Phe Met Glu Lys Phe Val Asp Pro Gly Asn His Asn Ser Gly 
        115                 120                 125             


Ile Asp Leu Leu Arg Thr Tyr Leu Trp Arg Cys Gln Phe Leu Leu Pro 
    130                 135                 140                 


Phe Val Ser Leu Gly Leu Met Cys Phe Gly Ala Leu Ile Gly Leu Cys 
145                 150                 155                 160 


Ala Cys Ile Cys Arg Ser Leu Tyr Pro Thr Ile Ala Thr Gly Ile Leu 
                165                 170                 175     


His Leu Leu Ala Gly Leu Cys Thr Leu Gly Ser Val Ser Cys Tyr Val 
            180                 185                 190         


Ala Gly Ile Glu Leu Leu His Gln Lys Leu Glu Leu Pro Asp Asn Val 
        195                 200                 205             


Ser Gly Glu Phe Gly Trp Ser Phe Cys Leu Ala Cys Val Ser Ala Pro 
    210                 215                 220                 


Leu Gln Phe Met Ala Ser Ala Leu Phe Ile Trp Ala Ala His Thr Asn 
225                 230                 235                 240 


Arg Lys Glu Tyr Thr 
                245 


<210>  2984
<211>  253
<212>  PRT
<213>  Homo Sapiens

<400>  2984

Met Asp Asn Arg Phe Ala Thr Ala Phe Val Ile Ala Cys Val Leu Ser 
1               5                   10                  15      


Leu Ile Ser Thr Ile Tyr Met Ala Ala Ser Ile Gly Thr Asp Phe Trp 
            20                  25                  30          


Tyr Glu Tyr Arg Ser Pro Val Gln Glu Asn Ser Ser Asp Leu Asn Lys 
        35                  40                  45              


Ser Ile Trp Asp Glu Phe Ile Ser Asp Glu Ala Asp Glu Lys Thr Tyr 
    50                  55                  60                  


Asn Asp Ala Leu Phe Arg Tyr Asn Gly Thr Val Gly Leu Trp Arg Arg 
65                  70                  75                  80  


Cys Ile Thr Ile Pro Lys Asn Met His Trp Tyr Ser Pro Pro Glu Arg 
                85                  90                  95      


Thr Glu Ser Phe Asp Val Val Thr Lys Cys Val Ser Phe Thr Leu Thr 
            100                 105                 110         


Glu Gln Phe Met Glu Lys Phe Val Asp Pro Gly Asn His Asn Ser Gly 
        115                 120                 125             


Ile Asp Leu Leu Arg Thr Tyr Leu Trp Arg Cys Gln Phe Leu Leu Pro 
    130                 135                 140                 


Phe Val Ser Leu Gly Leu Met Cys Phe Gly Ala Leu Ile Gly Leu Cys 
145                 150                 155                 160 


Ala Cys Ile Cys Arg Ser Leu Tyr Pro Thr Ile Ala Thr Gly Ile Leu 
                165                 170                 175     


His Leu Leu Ala Gly Leu Cys Thr Leu Gly Ser Val Ser Cys Tyr Val 
            180                 185                 190         


Ala Gly Ile Glu Leu Leu His Gln Lys Leu Glu Leu Pro Asp Asn Val 
        195                 200                 205             


Ser Gly Glu Phe Gly Trp Ser Phe Cys Leu Ala Cys Val Ser Ala Pro 
    210                 215                 220                 


Leu Gln Phe Met Ala Ser Ala Leu Phe Ile Trp Ala Ala His Thr Asn 
225                 230                 235                 240 


Arg Lys Glu Tyr Thr Leu Met Lys Ala Tyr Arg Val Ala 
                245                 250             


<210>  2985
<211>  253
<212>  PRT
<213>  Homo Sapiens

<400>  2985

Met Asp Asn Arg Phe Ala Thr Ala Phe Val Ile Ala Cys Val Leu Ser 
1               5                   10                  15      


Leu Ile Ser Thr Ile Tyr Met Ala Ala Ser Ile Gly Thr Asp Phe Trp 
            20                  25                  30          


Tyr Glu Tyr Arg Ser Pro Val Gln Glu Asn Ser Ser Asp Leu Asn Lys 
        35                  40                  45              


Ser Ile Trp Asp Glu Phe Ile Ser Asp Glu Ala Asp Glu Lys Thr Tyr 
    50                  55                  60                  


Asn Asp Ala Leu Phe Arg Tyr Asn Gly Thr Val Gly Leu Trp Arg Arg 
65                  70                  75                  80  


Cys Ile Thr Ile Pro Lys Asn Met His Trp Tyr Ser Pro Pro Glu Arg 
                85                  90                  95      


Thr Glu Ser Phe Asp Val Val Thr Lys Cys Val Ser Phe Thr Leu Thr 
            100                 105                 110         


Glu Gln Phe Met Glu Lys Phe Val Asp Pro Gly Asn His Asn Ser Gly 
        115                 120                 125             


Ile Asp Leu Leu Arg Thr Tyr Leu Trp Arg Cys Gln Phe Leu Leu Pro 
    130                 135                 140                 


Phe Val Ser Leu Gly Leu Met Cys Phe Gly Ala Leu Ile Gly Leu Cys 
145                 150                 155                 160 


Ala Cys Ile Cys Arg Ser Leu Tyr Pro Thr Ile Ala Thr Gly Ile Leu 
                165                 170                 175     


His Leu Leu Ala Gly Leu Cys Thr Leu Gly Ser Val Ser Cys Tyr Val 
            180                 185                 190         


Ala Gly Ile Glu Leu Leu His Gln Lys Leu Glu Leu Pro Asp Asn Val 
        195                 200                 205             


Ser Gly Glu Phe Gly Trp Ser Phe Cys Leu Ala Cys Val Ser Ala Pro 
    210                 215                 220                 


Leu Gln Phe Met Ala Ser Ala Leu Phe Ile Trp Ala Ala His Thr Asn 
225                 230                 235                 240 


Arg Lys Glu Tyr Thr Leu Met Lys Ala Tyr Arg Val Ala 
                245                 250             


<210>  2986
<211>  253
<212>  PRT
<213>  Homo Sapiens

<400>  2986

Met Asp Asn Arg Phe Ala Thr Ala Phe Val Ile Ala Cys Val Leu Ser 
1               5                   10                  15      


Leu Ile Ser Thr Ile Tyr Met Ala Ala Ser Ile Gly Thr Asp Phe Trp 
            20                  25                  30          


Tyr Glu Tyr Arg Ser Pro Val Gln Glu Asn Ser Ser Asp Leu Asn Lys 
        35                  40                  45              


Ser Ile Trp Asp Glu Phe Ile Ser Asp Glu Ala Asp Glu Lys Thr Tyr 
    50                  55                  60                  


Asn Asp Ala Leu Phe Arg Tyr Asn Gly Thr Val Gly Leu Trp Arg Arg 
65                  70                  75                  80  


Cys Ile Thr Ile Pro Lys Asn Met His Trp Tyr Ser Pro Pro Glu Arg 
                85                  90                  95      


Thr Glu Ser Phe Asp Val Val Thr Lys Cys Val Ser Phe Thr Leu Thr 
            100                 105                 110         


Glu Gln Phe Met Glu Lys Phe Val Asp Pro Gly Asn His Asn Ser Gly 
        115                 120                 125             


Ile Asp Leu Leu Arg Thr Tyr Leu Trp Arg Cys Gln Phe Leu Leu Pro 
    130                 135                 140                 


Phe Val Ser Leu Gly Leu Met Cys Phe Gly Ala Leu Ile Gly Leu Cys 
145                 150                 155                 160 


Ala Cys Ile Cys Arg Ser Leu Tyr Pro Thr Ile Ala Thr Gly Ile Leu 
                165                 170                 175     


His Leu Leu Ala Gly Leu Cys Thr Leu Gly Ser Val Ser Cys Tyr Val 
            180                 185                 190         


Ala Gly Ile Glu Leu Leu His Gln Lys Leu Glu Leu Pro Asp Asn Val 
        195                 200                 205             


Ser Gly Glu Phe Gly Trp Ser Phe Cys Leu Ala Cys Val Ser Ala Pro 
    210                 215                 220                 


Leu Gln Phe Met Ala Ser Ala Leu Phe Ile Trp Ala Ala His Thr Asn 
225                 230                 235                 240 


Arg Lys Glu Tyr Thr Leu Met Lys Ala Tyr Arg Val Ala 
                245                 250             


<210>  2987
<211>  253
<212>  PRT
<213>  Homo Sapiens

<400>  2987

Met Asp Asn Arg Phe Ala Thr Ala Phe Val Ile Ala Cys Val Leu Ser 
1               5                   10                  15      


Leu Ile Ser Thr Ile Tyr Met Ala Ala Ser Ile Gly Thr Asp Phe Trp 
            20                  25                  30          


Tyr Glu Tyr Arg Ser Pro Val Gln Glu Asn Ser Ser Asp Leu Asn Lys 
        35                  40                  45              


Ser Ile Trp Asp Glu Phe Ile Ser Asp Glu Ala Asp Glu Lys Thr Tyr 
    50                  55                  60                  


Asn Asp Ala Leu Phe Arg Tyr Asn Gly Thr Val Gly Leu Trp Arg Arg 
65                  70                  75                  80  


Cys Ile Thr Ile Pro Lys Asn Met His Trp Tyr Ser Pro Pro Glu Arg 
                85                  90                  95      


Thr Glu Ser Phe Asp Val Val Thr Lys Cys Val Ser Phe Thr Leu Thr 
            100                 105                 110         


Glu Gln Phe Met Glu Lys Phe Val Asp Pro Gly Asn His Asn Ser Gly 
        115                 120                 125             


Ile Asp Leu Leu Arg Thr Tyr Leu Trp Arg Cys Gln Phe Leu Leu Pro 
    130                 135                 140                 


Phe Val Ser Leu Gly Leu Met Cys Phe Gly Ala Leu Ile Gly Leu Cys 
145                 150                 155                 160 


Ala Cys Ile Cys Arg Ser Leu Tyr Pro Thr Ile Ala Thr Gly Ile Leu 
                165                 170                 175     


His Leu Leu Ala Gly Leu Cys Thr Leu Gly Ser Val Ser Cys Tyr Val 
            180                 185                 190         


Ala Gly Ile Glu Leu Leu His Gln Lys Leu Glu Leu Pro Asp Asn Val 
        195                 200                 205             


Ser Gly Glu Phe Gly Trp Ser Phe Cys Leu Ala Cys Val Ser Ala Pro 
    210                 215                 220                 


Leu Gln Phe Met Ala Ser Ala Leu Phe Ile Trp Ala Ala His Thr Asn 
225                 230                 235                 240 


Arg Lys Glu Tyr Thr Leu Met Lys Ala Tyr Arg Val Ala 
                245                 250             


<210>  2988
<211>  253
<212>  PRT
<213>  Homo Sapiens

<400>  2988

Met Asp Asn Arg Phe Ala Thr Ala Phe Val Ile Ala Cys Val Leu Ser 
1               5                   10                  15      


Leu Ile Ser Thr Ile Tyr Met Ala Ala Ser Ile Gly Thr Asp Phe Trp 
            20                  25                  30          


Tyr Glu Tyr Arg Ser Pro Val Gln Glu Asn Ser Ser Asp Leu Asn Lys 
        35                  40                  45              


Ser Ile Trp Asp Glu Phe Ile Ser Asp Glu Ala Asp Glu Lys Thr Tyr 
    50                  55                  60                  


Asn Asp Ala Leu Phe Arg Tyr Asn Gly Thr Val Gly Leu Trp Arg Arg 
65                  70                  75                  80  


Cys Ile Thr Ile Pro Lys Asn Met His Trp Tyr Ser Pro Pro Glu Arg 
                85                  90                  95      


Thr Glu Ser Phe Asp Val Val Thr Lys Cys Val Ser Phe Thr Leu Thr 
            100                 105                 110         


Glu Gln Phe Met Glu Lys Phe Val Asp Pro Gly Asn His Asn Ser Gly 
        115                 120                 125             


Ile Asp Leu Leu Arg Thr Tyr Leu Trp Arg Cys Gln Phe Leu Leu Pro 
    130                 135                 140                 


Phe Val Ser Leu Gly Leu Met Cys Phe Gly Ala Leu Ile Gly Leu Cys 
145                 150                 155                 160 


Ala Cys Ile Cys Arg Ser Leu Tyr Pro Thr Ile Ala Thr Gly Ile Leu 
                165                 170                 175     


His Leu Leu Ala Gly Leu Cys Thr Leu Gly Ser Val Ser Cys Tyr Val 
            180                 185                 190         


Ala Gly Ile Glu Leu Leu His Gln Lys Leu Glu Leu Pro Asp Asn Val 
        195                 200                 205             


Ser Gly Glu Phe Gly Trp Ser Phe Cys Leu Ala Cys Val Ser Ala Pro 
    210                 215                 220                 


Leu Gln Phe Met Ala Ser Ala Leu Phe Ile Trp Ala Ala His Thr Asn 
225                 230                 235                 240 


Arg Lys Glu Tyr Thr Leu Met Lys Ala Tyr Arg Val Ala 
                245                 250             


<210>  2989
<211>  253
<212>  PRT
<213>  Homo Sapiens

<400>  2989

Met Asp Asn Arg Phe Ala Thr Ala Phe Val Ile Ala Cys Val Leu Ser 
1               5                   10                  15      


Leu Ile Ser Thr Ile Tyr Met Ala Ala Ser Ile Gly Thr Asp Phe Trp 
            20                  25                  30          


Tyr Glu Tyr Arg Ser Pro Val Gln Glu Asn Ser Ser Asp Leu Asn Lys 
        35                  40                  45              


Ser Ile Trp Asp Glu Phe Ile Ser Asp Glu Ala Asp Glu Lys Thr Tyr 
    50                  55                  60                  


Asn Asp Ala Leu Phe Arg Tyr Asn Gly Thr Val Gly Leu Trp Arg Arg 
65                  70                  75                  80  


Cys Ile Thr Ile Pro Lys Asn Met His Trp Tyr Ser Pro Pro Glu Arg 
                85                  90                  95      


Thr Glu Ser Phe Asp Val Val Thr Lys Cys Val Ser Phe Thr Leu Thr 
            100                 105                 110         


Glu Gln Phe Met Glu Lys Phe Val Asp Pro Gly Asn His Asn Ser Gly 
        115                 120                 125             


Ile Asp Leu Leu Arg Thr Tyr Leu Trp Arg Cys Gln Phe Leu Leu Pro 
    130                 135                 140                 


Phe Val Ser Leu Gly Leu Met Cys Phe Gly Ala Leu Ile Gly Leu Cys 
145                 150                 155                 160 


Ala Cys Ile Cys Arg Ser Leu Tyr Pro Thr Ile Ala Thr Gly Ile Leu 
                165                 170                 175     


His Leu Leu Ala Gly Leu Cys Thr Leu Gly Ser Val Ser Cys Tyr Val 
            180                 185                 190         


Ala Gly Ile Glu Leu Leu His Gln Lys Leu Glu Leu Pro Asp Asn Val 
        195                 200                 205             


Ser Gly Glu Phe Gly Trp Ser Phe Cys Leu Ala Cys Val Ser Ala Pro 
    210                 215                 220                 


Leu Gln Phe Met Ala Ser Ala Leu Phe Ile Trp Ala Ala His Thr Asn 
225                 230                 235                 240 


Arg Lys Glu Tyr Thr Leu Met Lys Ala Tyr Arg Val Ala 
                245                 250             


<210>  2990
<211>  210
<212>  PRT
<213>  Homo Sapiens

<400>  2990

Met Asp Asn Arg Phe Ala Thr Ala Phe Val Ile Ala Cys Val Leu Ser 
1               5                   10                  15      


Leu Ile Ser Thr Ile Tyr Met Ala Ala Ser Ile Gly Thr Asp Phe Trp 
            20                  25                  30          


Tyr Glu Tyr Arg Ser Pro Val Gln Glu Asn Ser Ser Asp Leu Asn Lys 
        35                  40                  45              


Ser Ile Trp Asp Glu Phe Ile Ser Asp Glu Ala Asp Glu Lys Thr Tyr 
    50                  55                  60                  


Asn Asp Ala Leu Phe Arg Tyr Asn Gly Thr Val Gly Leu Trp Arg Arg 
65                  70                  75                  80  


Cys Ile Thr Ile Pro Lys Asn Met His Trp Tyr Ser Pro Pro Glu Arg 
                85                  90                  95      


Thr Glu Ser Phe Asp Val Val Thr Lys Cys Val Ser Phe Thr Leu Thr 
            100                 105                 110         


Glu Gln Phe Met Glu Lys Phe Val Asp Pro Gly Asn His Asn Ser Gly 
        115                 120                 125             


Ile Asp Leu Leu Arg Thr Tyr Leu Trp Arg Cys Gln Phe Leu Leu Pro 
    130                 135                 140                 


Phe Val Ser Leu Gly Leu Met Cys Phe Gly Ala Leu Ile Gly Leu Cys 
145                 150                 155                 160 


Ala Cys Ile Cys Arg Ser Leu Tyr Pro Thr Ile Ala Thr Gly Ile Leu 
                165                 170                 175     


His Leu Leu Ala Val Thr Lys Glu Ser Met Leu Pro Ala Gly Ala Glu 
            180                 185                 190         


Ser Lys His Thr Ala Thr Pro Ala His Ala Cys Val Gln Thr Gly Lys 
        195                 200                 205             


Pro Lys 
    210 


<210>  2991
<211>  106
<212>  PRT
<213>  Homo Sapiens

<400>  2991

Met Asp Asn Arg Phe Ala Thr Ala Phe Val Ile Ala Cys Val Leu Ser 
1               5                   10                  15      


Leu Ile Ser Thr Ile Tyr Met Ala Ala Ser Ile Gly Thr Asp Phe Trp 
            20                  25                  30          


Tyr Glu Tyr Arg Ser Pro Val Gln Glu Asn Ser Ser Asp Leu Asn Lys 
        35                  40                  45              


Ser Ile Trp Asp Glu Phe Ile Ser Asp Glu Ala Asp Glu Lys Thr Tyr 
    50                  55                  60                  


Asn Asp Ala Leu Phe Arg Tyr Asn Gly Thr Val Gly Leu Trp Arg Arg 
65                  70                  75                  80  


Cys Ile Thr Ile Pro Lys Asn Met His Trp Tyr Ser Pro Pro Glu Arg 
                85                  90                  95      


Thr Gly Asn Cys Ser Cys Ser Arg Val Ile 
            100                 105     


<210>  2992
<211>  100
<212>  PRT
<213>  Homo Sapiens

<400>  2992

Met Glu Lys Phe Val Asp Pro Gly Asn His Asn Ser Gly Ile Asp Leu 
1               5                   10                  15      


Leu Arg Thr Tyr Leu Trp Arg Cys Gln Phe Leu Leu Pro Phe Val Ser 
            20                  25                  30          


Leu Gly Leu Met Cys Phe Gly Ala Leu Ile Gly Leu Cys Ala Cys Ile 
        35                  40                  45              


Cys Arg Ser Leu Tyr Pro Thr Ile Ala Thr Gly Ile Leu His Leu Leu 
    50                  55                  60                  


Ala Gly Leu Cys Thr Leu Gly Ser Val Ser Cys Tyr Val Ala Gly Ile 
65                  70                  75                  80  


Glu Leu Leu His Gln Lys Leu Glu Leu Pro Asp Asn Val Ser Gly Glu 
                85                  90                  95      


Phe Gly Trp Ser 
            100 


<210>  2993
<211>  122
<212>  PRT
<213>  Homo Sapiens

<400>  2993

Met Glu Lys Phe Val Asp Pro Gly Asn His Asn Ser Gly Ile Asp Leu 
1               5                   10                  15      


Leu Arg Thr Tyr Leu Trp Arg Cys Gln Phe Leu Leu Pro Phe Val Ser 
            20                  25                  30          


Leu Gly Leu Met Cys Phe Gly Ala Leu Ile Gly Leu Cys Ala Cys Ile 
        35                  40                  45              


Cys Arg Ser Leu Tyr Pro Thr Ile Ala Thr Gly Ile Leu His Leu Leu 
    50                  55                  60                  


Ala Gly Leu Cys Thr Leu Gly Ser Val Ser Cys Tyr Val Ala Gly Ile 
65                  70                  75                  80  


Glu Leu Leu His Gln Lys Leu Glu Leu Pro Asp Asn Val Ser Gly Glu 
                85                  90                  95      


Phe Gly Trp Ser Phe Cys Leu Ala Cys Val Ser Ala Pro Leu Gln Phe 
            100                 105                 110         


Met Ala Ser Ala Leu Phe Ile Trp Ala Ala 
        115                 120         


<210>  2994
<211>  87
<212>  PRT
<213>  Homo Sapiens

<400>  2994

Met Gly Glu Ser Phe Asp Val Val Thr Lys Cys Val Ser Phe Thr Leu 
1               5                   10                  15      


Thr Glu Gln Phe Met Glu Lys Phe Val Asp Pro Gly Asn His Asn Ser 
            20                  25                  30          


Gly Ile Asp Leu Leu Arg Thr Tyr Leu Trp Arg Cys Gln Phe Leu Leu 
        35                  40                  45              


Pro Phe Val Ser Leu Gly Leu Met Cys Phe Gly Ala Leu Ile Gly Leu 
    50                  55                  60                  


Cys Ala Cys Ile Cys Arg Ser Leu Tyr Pro Thr Ile Ala Thr Gly Ile 
65                  70                  75                  80  


Leu His Leu Leu Ala Glu Asn 
                85          


<210>  2995
<211>  158
<212>  PRT
<213>  Homo Sapiens

<400>  2995

Met Gly Glu Ser Phe Asp Val Val Thr Lys Cys Val Ser Phe Thr Leu 
1               5                   10                  15      


Thr Glu Gln Phe Met Glu Lys Phe Val Asp Pro Gly Asn His Asn Ser 
            20                  25                  30          


Gly Ile Asp Leu Leu Arg Thr Tyr Leu Trp Arg Cys Gln Phe Leu Leu 
        35                  40                  45              


Pro Phe Val Ser Leu Gly Leu Met Cys Phe Gly Ala Leu Ile Gly Leu 
    50                  55                  60                  


Cys Ala Cys Ile Cys Arg Ser Leu Tyr Pro Thr Ile Ala Thr Gly Ile 
65                  70                  75                  80  


Leu His Leu Leu Ala Gly Leu Cys Thr Leu Gly Ser Val Ser Cys Tyr 
                85                  90                  95      


Val Ala Gly Ile Glu Leu Leu His Gln Lys Leu Glu Leu Pro Asp Asn 
            100                 105                 110         


Val Ser Gly Glu Phe Gly Trp Ser Phe Cys Leu Ala Cys Val Ser Ala 
        115                 120                 125             


Pro Leu Gln Phe Met Ala Ser Ala Leu Phe Ile Trp Ala Ala His Thr 
    130                 135                 140                 


Asn Arg Lys Glu Tyr Thr Leu Met Lys Ala Tyr Arg Val Ala 
145                 150                 155             


<210>  2996
<211>  276
<212>  PRT
<213>  Homo Sapiens

<400>  2996

Met Gly Gly Asp Arg Leu Glu Asn Lys Thr Ser Val Ser Val Ala Ser 
1               5                   10                  15      


Trp Ser Ser Leu Asn Ala Arg Met Asp Asn Arg Phe Ala Thr Ala Phe 
            20                  25                  30          


Val Ile Ala Cys Val Leu Ser Leu Ile Ser Thr Ile Tyr Met Ala Ala 
        35                  40                  45              


Ser Ile Gly Thr Asp Phe Trp Tyr Glu Tyr Arg Ser Pro Val Gln Glu 
    50                  55                  60                  


Asn Ser Ser Asp Leu Asn Lys Ser Ile Trp Asp Glu Phe Ile Ser Asp 
65                  70                  75                  80  


Glu Ala Asp Glu Lys Thr Tyr Asn Asp Ala Leu Phe Arg Tyr Asn Gly 
                85                  90                  95      


Thr Val Gly Leu Trp Arg Arg Cys Ile Thr Ile Pro Lys Asn Met His 
            100                 105                 110         


Trp Tyr Ser Pro Pro Glu Arg Thr Glu Ser Phe Asp Val Val Thr Lys 
        115                 120                 125             


Cys Val Ser Phe Thr Leu Thr Glu Gln Phe Met Glu Lys Phe Val Asp 
    130                 135                 140                 


Pro Gly Asn His Asn Ser Gly Ile Asp Leu Leu Arg Thr Tyr Leu Trp 
145                 150                 155                 160 


Arg Cys Gln Phe Leu Leu Pro Phe Val Ser Leu Gly Leu Met Cys Phe 
                165                 170                 175     


Gly Ala Leu Ile Gly Leu Cys Ala Cys Ile Cys Arg Ser Leu Tyr Pro 
            180                 185                 190         


Thr Ile Ala Thr Gly Ile Leu His Leu Leu Ala Gly Leu Cys Thr Leu 
        195                 200                 205             


Gly Ser Val Ser Cys Tyr Val Ala Gly Ile Glu Leu Leu His Gln Lys 
    210                 215                 220                 


Leu Glu Leu Pro Asp Asn Val Ser Gly Glu Phe Gly Trp Ser Phe Cys 
225                 230                 235                 240 


Leu Ala Cys Val Ser Ala Pro Leu Gln Phe Met Ala Ser Ala Leu Phe 
                245                 250                 255     


Ile Trp Ala Ala His Thr Asn Arg Lys Glu Tyr Thr Leu Met Lys Ala 
            260                 265                 270         


Tyr Arg Val Ala 
        275     


<210>  2997
<211>  317
<212>  PRT
<213>  Homo Sapiens

<400>  2997

Met Gln Ala Ala Trp Leu Leu Gly Ala Leu Val Val Pro Gln Leu Leu 
1               5                   10                  15      


Gly Phe Gly His Gly Ala Arg Gly Ala Glu Arg Glu Trp Glu Gly Gly 
            20                  25                  30          


Trp Gly Gly Ala Gln Glu Glu Glu Arg Glu Arg Glu Ala Leu Met Leu 
        35                  40                  45              


Lys His Leu Gln Glu Ala Leu Gly Leu Pro Ala Gly Arg Gly Asp Glu 
    50                  55                  60                  


Asn Pro Ala Gly Thr Val Glu Gly Lys Glu Asp Trp Glu Met Glu Glu 
65                  70                  75                  80  


Asp Gln Gly Glu Glu Glu Glu Glu Glu Ala Thr Pro Thr Pro Ser Ser 
                85                  90                  95      


Gly Pro Ser Pro Ser Pro Thr Pro Glu Asp Ile Val Thr Tyr Ile Leu 
            100                 105                 110         


Gly Arg Leu Ala Gly Leu Asp Ala Gly Leu His Gln Leu His Val Arg 
        115                 120                 125             


Leu His Ala Leu Asp Thr Arg Val Val Glu Leu Thr Gln Gly Leu Arg 
    130                 135                 140                 


Gln Leu Arg Asn Ala Ala Gly Asp Thr Arg Asp Ala Val Gln Ala Leu 
145                 150                 155                 160 


Gln Glu Ala Gln Gly Arg Ala Glu Arg Glu His Gly Arg Leu Glu Asp 
                165                 170                 175     


Ser Glu Cys Met Thr Pro Pro Pro Ser Leu Pro Gly Pro Ala His Arg 
            180                 185                 190         


Leu Pro Glu Gly Ala Ala Pro Gly Pro Gln Val Leu Pro Ala Leu Ala 
        195                 200                 205             


Arg Leu Arg Ser Ser Gly Gly Gly Ala Gly Ala Val His Gly Ala Gly 
    210                 215                 220                 


Arg Glu Pro Gly Ala Ala Gly Arg Pro Pro Ala Asp Gly Gly Ala His 
225                 230                 235                 240 


Ser Val Pro Ala Arg Gly Ala Arg Ser Leu Gln Leu Ala Arg Val Ala 
                245                 250                 255     


Gly Arg Ala Arg Ser Ala Arg Arg Gly Pro Leu Pro Leu Arg Lys Arg 
            260                 265                 270         


Pro Ala Arg Val Leu Leu Arg Leu Ala Ser Leu Thr Pro Pro Arg Ala 
        275                 280                 285             


Arg Arg Pro Ala Gln Arg Leu Ala Ala Ser Ala Gln Pro Gly Pro Ala 
    290                 295                 300                 


Gln Arg Trp His Ala Arg Glu Leu Arg Gly Ala Gly Leu 
305                 310                 315         


<210>  2998
<211>  323
<212>  PRT
<213>  Homo Sapiens

<400>  2998

Met Gln Ala Ala Trp Leu Leu Gly Ala Leu Val Val Pro Gln Leu Leu 
1               5                   10                  15      


Gly Phe Gly His Gly Ala Arg Gly Ala Glu Arg Glu Trp Glu Gly Gly 
            20                  25                  30          


Trp Gly Gly Ala Gln Glu Glu Glu Arg Glu Arg Glu Ala Leu Met Leu 
        35                  40                  45              


Lys His Leu Gln Glu Ala Leu Gly Leu Pro Ala Gly Arg Gly Asp Glu 
    50                  55                  60                  


Asn Pro Ala Gly Thr Val Glu Gly Lys Glu Asp Trp Glu Met Glu Glu 
65                  70                  75                  80  


Asp Gln Gly Glu Glu Glu Glu Glu Glu Ala Thr Pro Thr Pro Ser Ser 
                85                  90                  95      


Gly Pro Ser Pro Ser Pro Thr Pro Glu Asp Ile Val Thr Tyr Ile Leu 
            100                 105                 110         


Gly Arg Leu Ala Gly Leu Asp Ala Gly Leu His Gln Leu His Val Arg 
        115                 120                 125             


Leu His Ala Leu Asp Thr Arg Val Val Glu Leu Thr Gln Gly Leu Arg 
    130                 135                 140                 


Gln Leu Arg Asn Ala Ala Gly Asp Thr Arg Asp Ala Val Gln Ala Leu 
145                 150                 155                 160 


Gln Glu Ala Gln Gly Arg Ala Glu Arg Glu His Gly Arg Leu Glu Gly 
                165                 170                 175     


Cys Leu Lys Gly Leu Arg Leu Gly His Lys Cys Phe Leu Leu Ser Arg 
            180                 185                 190         


Asp Phe Glu Ala Gln Ala Ala Ala Gln Ala Arg Cys Thr Ala Arg Gly 
        195                 200                 205             


Gly Ser Leu Ala Gln Pro Ala Asp Arg Gln Gln Met Glu Ala Leu Thr 
    210                 215                 220                 


Arg Tyr Leu Arg Ala Ala Leu Ala Pro Tyr Asn Trp Pro Val Trp Leu 
225                 230                 235                 240 


Gly Val His Asp Arg Arg Ala Glu Gly Leu Tyr Leu Phe Glu Asn Gly 
                245                 250                 255     


Gln Arg Val Ser Phe Phe Ala Trp His Arg Ser Pro Arg Pro Glu Leu 
            260                 265                 270         


Gly Ala Gln Pro Ser Ala Ser Pro His Pro Leu Ser Pro Asp Gln Pro 
        275                 280                 285             


Asn Gly Gly Thr Leu Glu Asn Cys Val Ala Gln Ala Ser Asp Asp Gly 
    290                 295                 300                 


Ser Trp Trp Asp His Asp Cys Gln Arg Arg Leu Tyr Tyr Val Cys Glu 
305                 310                 315                 320 


Phe Pro Phe 
            


<210>  2999
<211>  245
<212>  PRT
<213>  Homo Sapiens

<400>  2999

Met Gln Ala Ala Trp Leu Leu Gly Ala Leu Val Val Pro Gln Leu Leu 
1               5                   10                  15      


Gly Phe Gly His Gly Ala Arg Gly Ala Glu Arg Glu Trp Glu Gly Gly 
            20                  25                  30          


Trp Gly Gly Ala Gln Glu Glu Glu Arg Glu Arg Glu Ala Leu Met Leu 
        35                  40                  45              


Lys His Leu Gln Glu Ala Leu Gly Leu Pro Ala Gly Arg Gly Asp Glu 
    50                  55                  60                  


Asn Pro Ala Gly Thr Val Glu Gly Lys Glu Asp Trp Glu Met Glu Glu 
65                  70                  75                  80  


Asp Gln Gly Glu Glu Glu Glu Glu Glu Ala Thr Pro Thr Pro Ser Ser 
                85                  90                  95      


Gly Pro Ser Pro Ser Pro Thr Pro Glu Asp Ile Val Thr Tyr Ile Leu 
            100                 105                 110         


Gly Arg Leu Ala Gly Leu Asp Ala Gly Leu His Gln Leu His Val Arg 
        115                 120                 125             


Leu His Ala Leu Asp Thr Arg Val Val Glu Leu Thr Gln Gly Leu Arg 
    130                 135                 140                 


Gln Leu Arg Asn Ala Ala Gly Asp Thr Arg Asp Ala Val Gln Ala Leu 
145                 150                 155                 160 


Gln Glu Ala Gln Gly Arg Ala Glu Arg Glu His Gly Arg Leu Glu Gly 
                165                 170                 175     


Cys Leu Lys Gly Leu Arg Leu Gly His Lys Cys Phe Leu Leu Ser Arg 
            180                 185                 190         


Asp Phe Glu Ala Gln Pro Ser Ala Ser Pro His Pro Leu Ser Pro Asp 
        195                 200                 205             


Gln Pro Asn Gly Gly Thr Leu Glu Asn Cys Val Ala Gln Ala Ser Asp 
    210                 215                 220                 


Asp Gly Ser Trp Trp Asp His Asp Cys Gln Arg Arg Leu Tyr Tyr Val 
225                 230                 235                 240 


Cys Glu Phe Pro Phe 
                245 


<210>  3000
<211>  118
<212>  PRT
<213>  Homo Sapiens

<400>  3000

Leu Ala Lys Gly Arg Ile Gln Ala Arg Arg Met Lys Met Gln Arg Ile 
1               5                   10                  15      


Ala Ala Leu Leu Asp Leu Pro Ile Gln Pro Thr Thr Glu Val Leu Gly 
            20                  25                  30          


Phe Gly Leu Gly Ser Ser Thr Ser Thr Gln His Leu Pro Phe Arg Phe 
        35                  40                  45              


Tyr Asp Gln Gly Arg Arg Gly Ser Ser Asp Pro Thr Val Gln Arg Ser 
    50                  55                  60                  


Val Phe Ala Ser Val Asp Lys Val Pro Ala Leu Leu Thr Ala Ala Val 
65                  70                  75                  80  


Glu Arg Gln Pro Arg Trp Pro Leu Pro Ser Leu Leu Val Pro Trp Leu 
                85                  90                  95      


Thr Asp Cys Cys Gly Gly Leu Cys Leu Leu Ile Tyr Arg Arg Phe Ser 
            100                 105                 110         


Arg Ile Val Phe Lys Ile 
        115             


<210>  3001
<211>  906
<212>  PRT
<213>  Homo Sapiens

<400>  3001

Met Phe Gly Arg Ser Arg Ser Trp Val Gly Gly Gly His Gly Lys Thr 
1               5                   10                  15      


Ser Arg Asn Ile His Ser Leu Asp His Leu Lys Tyr Leu Tyr His Val 
            20                  25                  30          


Leu Thr Lys Asn Thr Thr Val Thr Glu Gln Asn Arg Asn Leu Leu Val 
        35                  40                  45              


Glu Thr Ile Arg Ser Ile Thr Glu Ile Leu Ile Trp Gly Asp Gln Asn 
    50                  55                  60                  


Asp Ser Ser Val Phe Asp Phe Phe Leu Glu Lys Asn Met Phe Val Phe 
65                  70                  75                  80  


Phe Leu Asn Ile Leu Arg Gln Lys Ser Gly Arg Tyr Val Cys Val Gln 
                85                  90                  95      


Leu Leu Gln Thr Leu Asn Ile Leu Phe Glu Asn Ile Ser His Glu Thr 
            100                 105                 110         


Ser Leu Tyr Tyr Leu Leu Ser Asn Asn Tyr Val Asn Ser Ile Ile Val 
        115                 120                 125             


His Lys Phe Asp Phe Ser Asp Glu Glu Ile Met Ala Tyr Tyr Ile Ser 
    130                 135                 140                 


Phe Leu Lys Thr Leu Ser Leu Lys Leu Asn Asn His Thr Val His Phe 
145                 150                 155                 160 


Phe Tyr Asn Glu His Thr Asn Asp Phe Ala Leu Tyr Thr Glu Ala Ile 
                165                 170                 175     


Lys Phe Phe Asn His Pro Glu Ser Met Val Arg Ile Ala Val Arg Thr 
            180                 185                 190         


Ile Thr Leu Asn Val Tyr Lys Val Asp Asn Gln Ala Met Leu His Tyr 
        195                 200                 205             


Ile Arg Asp Lys Thr Ala Val Pro Tyr Phe Ser Asn Leu Val Trp Phe 
    210                 215                 220                 


Ile Gly Ser His Val Ile Glu Leu Asp Asp Cys Val Gln Thr Asp Glu 
225                 230                 235                 240 


Glu His Arg Asn Arg Gly Lys Leu Ser Asp Leu Val Ala Glu His Leu 
                245                 250                 255     


Asp His Leu His Tyr Leu Asn Asp Ile Leu Ile Ile Asn Cys Glu Phe 
            260                 265                 270         


Leu Asn Asp Val Leu Thr Asp His Leu Leu Asn Arg Leu Phe Leu Pro 
        275                 280                 285             


Leu Tyr Val Tyr Ser Leu Glu Asn Gln Asp Lys Gly Gly Glu Arg Pro 
    290                 295                 300                 


Lys Ile Ser Leu Pro Val Ser Leu Tyr Leu Leu Ser Gln Val Phe Leu 
305                 310                 315                 320 


Ile Ile His His Ala Pro Leu Val Asn Ser Leu Ala Glu Val Ile Leu 
                325                 330                 335     


Asn Gly Asp Leu Ser Glu Met Tyr Ala Lys Thr Glu Gln Asp Ile Gln 
            340                 345                 350         


Arg Ser Ser Ala Lys Pro Ser Ile Arg Cys Phe Ile Lys Pro Thr Glu 
        355                 360                 365             


Thr Leu Glu Arg Ser Leu Glu Met Asn Lys His Lys Gly Lys Arg Arg 
    370                 375                 380                 


Val Gln Lys Arg Pro Asn Tyr Lys Asn Val Gly Glu Glu Glu Asp Glu 
385                 390                 395                 400 


Glu Lys Gly Pro Thr Glu Asp Ala Gln Glu Asp Ala Glu Lys Ala Lys 
                405                 410                 415     


Glu Ile Glu Met Val Ile Met Glu Arg Ser Lys Leu Ser Glu Leu Ala 
            420                 425                 430         


Ala Ser Thr Ser Val Gln Glu Gln Asn Thr Thr Asp Glu Glu Lys Ser 
        435                 440                 445             


Ala Ala Ala Thr Cys Ser Glu Ser Thr Gln Trp Ser Arg Pro Phe Leu 
    450                 455                 460                 


Asp Met Val Tyr His Ala Leu Asp Ser Pro Asp Asp Asp Tyr His Ala 
465                 470                 475                 480 


Leu Phe Val Leu Cys Leu Leu Tyr Ala Met Ser His Asn Lys Gly Met 
                485                 490                 495     


Asp Pro Glu Lys Leu Glu Arg Ile Gln Leu Pro Val Pro Asn Ala Ala 
            500                 505                 510         


Glu Lys Thr Thr Tyr Asn His Pro Leu Ala Glu Arg Leu Ile Arg Ile 
        515                 520                 525             


Met Asn Asn Ala Ala Gln Pro Asp Gly Lys Ile Arg Leu Ala Thr Leu 
    530                 535                 540                 


Glu Leu Ser Cys Leu Leu Leu Lys Gln Gln Val Leu Met Ser Ala Gly 
545                 550                 555                 560 


Cys Ile Met Lys Asp Val His Leu Ala Cys Leu Glu Gly Ala Arg Glu 
                565                 570                 575     


Glu Ser Val His Leu Val Arg His Phe Tyr Lys Gly Glu Asp Ile Phe 
            580                 585                 590         


Leu Asp Met Phe Glu Asp Glu Tyr Arg Ser Met Thr Met Lys Pro Met 
        595                 600                 605             


Asn Val Glu Tyr Leu Met Met Asp Ala Ser Ile Leu Leu Pro Pro Thr 
    610                 615                 620                 


Gly Thr Pro Leu Thr Gly Ile Asp Phe Val Lys Arg Leu Pro Cys Gly 
625                 630                 635                 640 


Asp Val Glu Lys Thr Arg Arg Ala Ile Arg Val Phe Phe Met Leu Arg 
                645                 650                 655     


Ser Leu Ser Leu Gln Leu Arg Gly Glu Pro Glu Thr Gln Leu Pro Leu 
            660                 665                 670         


Thr Arg Glu Glu Asp Leu Ile Lys Thr Asp Asp Val Leu Asp Leu Asn 
        675                 680                 685             


Asn Ser Asp Leu Ile Ala Cys Thr Val Ile Thr Lys Asp Gly Gly Met 
    690                 695                 700                 


Val Gln Arg Phe Leu Ala Val Asp Ile Tyr Gln Met Ser Leu Val Glu 
705                 710                 715                 720 


Pro Asp Val Ser Arg Leu Gly Trp Gly Val Val Lys Phe Ala Gly Leu 
                725                 730                 735     


Leu Gln Asp Met Gln Val Thr Gly Val Glu Asp Asp Ser Arg Ala Leu 
            740                 745                 750         


Asn Ile Thr Ile His Lys Pro Ala Ser Ser Pro His Ser Lys Pro Phe 
        755                 760                 765             


Pro Ile Leu Gln Ala Thr Phe Ile Phe Ser Asp His Ile Arg Cys Ile 
    770                 775                 780                 


Ile Ala Lys Gln Arg Leu Ala Lys Gly Arg Ile Gln Ala Arg Arg Met 
785                 790                 795                 800 


Lys Met Gln Arg Ile Ala Ala Leu Leu Asp Leu Pro Ile Gln Pro Thr 
                805                 810                 815     


Thr Glu Val Leu Gly Phe Gly Leu Gly Ser Ser Thr Ser Thr Gln His 
            820                 825                 830         


Leu Pro Phe Arg Phe Tyr Asp Gln Gly Arg Arg Gly Ser Ser Asp Pro 
        835                 840                 845             


Thr Val Gln Arg Ser Val Phe Ala Ser Val Asp Lys Val Pro Gly Glu 
    850                 855                 860                 


Pro Ala Pro Arg Pro Ala Pro Gln Leu Val His His Gly Gly Arg Ser 
865                 870                 875                 880 


Arg Ser Phe Ser Leu Trp Ser Leu Cys Glu Leu Pro Phe Leu Ser Gln 
                885                 890                 895     


Lys Pro Arg Arg Leu Ala Ala Pro Ala Ser 
            900                 905     


<210>  3002
<211>  1053
<212>  PRT
<213>  Homo Sapiens

<400>  3002

Met Phe Gly Arg Ser Arg Ser Trp Val Gly Gly Gly His Gly Lys Thr 
1               5                   10                  15      


Ser Arg Asn Ile His Ser Leu Asp His Leu Lys Tyr Leu Tyr His Val 
            20                  25                  30          


Leu Thr Lys Asn Thr Thr Val Thr Glu Gln Asn Arg Asn Leu Leu Val 
        35                  40                  45              


Glu Thr Ile Arg Ser Ile Thr Glu Ile Leu Ile Trp Gly Asp Gln Asn 
    50                  55                  60                  


Asp Ser Ser Val Phe Asp Phe Phe Leu Glu Lys Asn Met Phe Val Phe 
65                  70                  75                  80  


Phe Leu Asn Ile Leu Arg Gln Lys Ser Gly Arg Tyr Val Cys Val Gln 
                85                  90                  95      


Leu Leu Gln Thr Leu Asn Ile Leu Phe Glu Asn Ile Ser His Glu Thr 
            100                 105                 110         


Ser Leu Tyr Tyr Leu Leu Ser Asn Asn Tyr Val Asn Ser Ile Ile Val 
        115                 120                 125             


His Lys Phe Asp Phe Ser Asp Glu Glu Ile Met Ala Tyr Tyr Ile Ser 
    130                 135                 140                 


Phe Leu Lys Thr Leu Ser Leu Lys Leu Asn Asn His Thr Val His Phe 
145                 150                 155                 160 


Phe Tyr Asn Glu His Thr Asn Asp Phe Ala Leu Tyr Thr Glu Ala Ile 
                165                 170                 175     


Lys Phe Phe Asn His Pro Glu Ser Met Val Arg Ile Ala Val Arg Thr 
            180                 185                 190         


Ile Thr Leu Asn Val Tyr Lys Val Ser Leu Asp Asn Gln Ala Met Leu 
        195                 200                 205             


His Tyr Ile Arg Asp Lys Thr Ala Val Pro Tyr Phe Ser Asn Leu Val 
    210                 215                 220                 


Trp Phe Ile Gly Ser His Val Ile Glu Leu Asp Asp Cys Val Gln Thr 
225                 230                 235                 240 


Asp Glu Glu His Arg Asn Arg Gly Lys Leu Ser Asp Leu Val Ala Glu 
                245                 250                 255     


His Leu Asp His Leu His Tyr Leu Asn Asp Ile Leu Ile Ile Asn Cys 
            260                 265                 270         


Glu Phe Leu Asn Asp Val Leu Thr Asp His Leu Leu Asn Arg Leu Phe 
        275                 280                 285             


Leu Pro Leu Tyr Val Tyr Ser Leu Glu Asn Gln Asp Lys Gly Gly Glu 
    290                 295                 300                 


Arg Pro Lys Ile Ser Leu Pro Val Ser Leu Tyr Leu Leu Ser Gln Val 
305                 310                 315                 320 


Phe Leu Ile Ile His His Ala Pro Leu Val Asn Ser Leu Ala Glu Val 
                325                 330                 335     


Ile Leu Asn Gly Asp Leu Ser Glu Met Tyr Ala Lys Thr Glu Gln Asp 
            340                 345                 350         


Ile Gln Arg Ser Ser Ala Lys Pro Ser Ile Arg Cys Phe Ile Lys Pro 
        355                 360                 365             


Thr Glu Thr Leu Glu Arg Ser Leu Glu Met Asn Lys His Lys Gly Lys 
    370                 375                 380                 


Arg Arg Val Gln Lys Arg Pro Asn Tyr Lys Asn Val Gly Glu Glu Glu 
385                 390                 395                 400 


Asp Glu Glu Lys Gly Pro Thr Glu Asp Ala Gln Glu Asp Ala Glu Lys 
                405                 410                 415     


Ala Lys Gly Thr Glu Gly Gly Ser Lys Gly Ile Lys Thr Ser Gly Glu 
            420                 425                 430         


Ser Glu Glu Ile Glu Met Val Ile Met Glu Arg Ser Lys Leu Ser Glu 
        435                 440                 445             


Leu Ala Ala Ser Thr Ser Val Gln Glu Gln Asn Thr Thr Asp Glu Glu 
    450                 455                 460                 


Lys Ser Ala Ala Ala Thr Cys Ser Glu Ser Thr Gln Trp Ser Arg Pro 
465                 470                 475                 480 


Phe Leu Asp Met Val Tyr His Ala Leu Asp Ser Pro Asp Asp Asp Tyr 
                485                 490                 495     


His Ala Leu Phe Val Leu Cys Leu Leu Tyr Ala Met Ser His Asn Lys 
            500                 505                 510         


Gly Met Asp Pro Glu Lys Leu Glu Arg Ile Gln Leu Pro Val Pro Asn 
        515                 520                 525             


Ala Ala Glu Lys Thr Thr Tyr Asn His Pro Leu Ala Glu Arg Leu Ile 
    530                 535                 540                 


Arg Ile Met Asn Asn Ala Ala Gln Pro Asp Gly Lys Ile Arg Leu Ala 
545                 550                 555                 560 


Thr Leu Glu Leu Ser Cys Leu Leu Leu Lys Gln Gln Val Leu Met Ser 
                565                 570                 575     


Ala Gly Cys Ile Met Lys Asp Val His Leu Ala Cys Leu Glu Gly Ala 
            580                 585                 590         


Arg Glu Glu Ser Val His Leu Val Arg His Phe Tyr Lys Gly Glu Asp 
        595                 600                 605             


Ile Phe Leu Asp Met Phe Glu Asp Glu Tyr Arg Ser Met Thr Met Lys 
    610                 615                 620                 


Pro Met Asn Val Glu Tyr Leu Met Met Asp Ala Ser Ile Leu Leu Pro 
625                 630                 635                 640 


Pro Thr Gly Thr Pro Leu Thr Gly Ile Asp Phe Val Lys Arg Leu Pro 
                645                 650                 655     


Cys Gly Asp Val Glu Lys Thr Arg Arg Ala Ile Arg Val Phe Phe Met 
            660                 665                 670         


Leu Arg Ser Leu Ser Leu Gln Leu Arg Gly Glu Pro Glu Thr Gln Leu 
        675                 680                 685             


Pro Leu Thr Arg Glu Glu Asp Leu Ile Lys Thr Asp Asp Val Leu Asp 
    690                 695                 700                 


Leu Asn Asn Ser Asp Leu Ile Ala Cys Thr Val Ile Thr Lys Asp Gly 
705                 710                 715                 720 


Gly Met Val Gln Arg Phe Leu Ala Val Asp Ile Tyr Gln Met Ser Leu 
                725                 730                 735     


Val Glu Pro Asp Val Ser Arg Leu Gly Trp Gly Val Val Lys Phe Ala 
            740                 745                 750         


Gly Leu Leu Gln Asp Met Gln Val Thr Gly Val Glu Asp Asp Ser Arg 
        755                 760                 765             


Ala Leu Asn Ile Thr Ile His Lys Pro Ala Ser Ser Pro His Ser Lys 
    770                 775                 780                 


Pro Phe Pro Ile Leu Gln Ala Thr Phe Ile Phe Ser Asp His Ile Arg 
785                 790                 795                 800 


Cys Ile Ile Ala Lys Gln Arg Leu Ala Lys Gly Arg Ile Gln Ala Arg 
                805                 810                 815     


Arg Met Lys Met Gln Arg Ile Ala Ala Leu Leu Asp Leu Pro Ile Gln 
            820                 825                 830         


Pro Thr Thr Glu Val Leu Gly Phe Gly Leu Gly Ser Ser Thr Ser Thr 
        835                 840                 845             


Gln His Leu Pro Phe Arg Phe Tyr Asp Gln Gly Arg Arg Gly Ser Ser 
    850                 855                 860                 


Asp Pro Thr Val Gln Arg Ser Val Phe Ala Ser Val Asp Lys Val Pro 
865                 870                 875                 880 


Gly Phe Ala Val Ala Gln Cys Ile Asn Gln His Ser Ser Pro Ser Leu 
                885                 890                 895     


Ser Ser Gln Ser Pro Pro Ser Ala Ser Gly Ser Pro Ser Gly Ser Gly 
            900                 905                 910         


Ser Thr Ser His Cys Asp Ser Gly Gly Thr Ser Ser Ser Ser Thr Pro 
        915                 920                 925             


Ser Thr Ala Gln Ser Pro Ala Asp Ala Pro Met Ser Pro Glu Leu Pro 
    930                 935                 940                 


Lys Pro His Leu Pro Asp Gln Leu Val Ile Val Asn Glu Thr Glu Ala 
945                 950                 955                 960 


Asp Ser Lys Pro Ser Lys Asn Val Ala Arg Ser Ala Ala Val Glu Thr 
                965                 970                 975     


Ala Ser Leu Ser Pro Ser Leu Val Pro Ala Arg Gln Pro Thr Ile Ser 
            980                 985                 990         


Leu Leu Cys Glu Asp Thr Ala Asp  Thr Leu Ser Val Glu  Ser Leu Thr 
        995                 1000                 1005             


Leu Val  Pro Pro Val Asp Pro  His Ser Leu Arg Ser  Leu Thr Gly 
    1010                 1015                 1020             


Met Pro  Pro Leu Ser Thr Pro  Ala Ala Ala Cys Thr  Glu Pro Val 
    1025                 1030                 1035             


Gly Glu  Glu Ala Ala Cys Ala  Glu Pro Val Gly Thr  Ala Glu Asp 
    1040                 1045                 1050             


<210>  3003
<211>  60
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3003

Xaa Glu Val Leu Gly Phe Gly Leu Gly Ser Ser Thr Ser Thr Gln His 
1               5                   10                  15      


Leu Pro Phe Arg Phe Tyr Asp Gln Gly Arg Arg Gly Ser Ser Asp Pro 
            20                  25                  30          


Thr Val Gln Arg Ser Val Phe Ala Ser Val Asp Lys Val Pro Asp Pro 
        35                  40                  45              


Ser Leu Cys Ser Cys Ile Ser Tyr Met Cys Gln Ser 
    50                  55                  60  


<210>  3004
<211>  152
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3004

Xaa Lys Gly Arg Ile Gln Ala Arg Arg Met Lys Met Gln Arg Ile Ala 
1               5                   10                  15      


Ala Leu Leu Asp Leu Pro Ile Gln Pro Thr Thr Glu Val Leu Gly Phe 
            20                  25                  30          


Gly Leu Gly Ser Ser Thr Ser Thr Gln His Leu Pro Phe Arg Phe Tyr 
        35                  40                  45              


Asp Gln Gly Arg Arg Gly Ser Ser Asp Pro Thr Val Gln Arg Ser Val 
    50                  55                  60                  


Phe Ala Ser Val Asp Lys Val Pro Gly Phe Ala Val Ala Gln Cys Ile 
65                  70                  75                  80  


Asn Gln His Ser Ser Pro Ser Leu Ser Ser Gln Ser Pro Pro Ser Ala 
                85                  90                  95      


Ser Gly Ser Pro Ser Gly Ser Gly Ser Thr Ser His Cys Asp Ser Gly 
            100                 105                 110         


Gly Thr Ser Ser Ser Ser Thr Pro Ser Thr Ala Gln Ser Pro Ala Val 
        115                 120                 125             


Arg Ser Gly Arg Lys Gly Arg Arg Arg Val Phe Ser Leu Ser Glu Ala 
    130                 135                 140                 


Asp Ser His Gly Gly His Trp Val 
145                 150         


<210>  3005
<211>  128
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3005

Xaa Met Gln Val Thr Gly Val Glu Asp Asp Ser Arg Ala Leu Asn Ile 
1               5                   10                  15      


Thr Ile His Lys Pro Ala Ser Ser Pro His Ser Lys Pro Phe Pro Ile 
            20                  25                  30          


Leu Gln Ala Thr Phe Ile Phe Ser Asp His Ile Arg Cys Ile Ile Ala 
        35                  40                  45              


Lys Gln Arg Leu Ala Lys Gly Arg Ile Gln Ala Arg Arg Met Lys Met 
    50                  55                  60                  


Gln Arg Ile Ala Ala Leu Leu Asp Leu Pro Ile Gln Pro Thr Thr Glu 
65                  70                  75                  80  


Val Leu Gly Phe Gly Leu Gly Ser Ser Thr Ser Thr Gln His Leu Pro 
                85                  90                  95      


Phe Arg Phe Tyr Asp Gln Gly Arg Arg Gly Ser Ser Asp Pro Thr Val 
            100                 105                 110         


Gln Arg Ser Val Phe Ala Ser Val Asp Lys Val Pro Gly Phe Gln Gly 
        115                 120                 125             


<210>  3006
<211>  446
<212>  PRT
<213>  Homo Sapiens

<400>  3006

Met Leu His Pro Glu Thr Ser Pro Gly Arg Gly His Leu Leu Ala Val 
1               5                   10                  15      


Leu Leu Ala Leu Leu Gly Thr Ala Trp Ala Glu Val Trp Pro Pro Gln 
            20                  25                  30          


Leu Gln Glu Gln Ala Pro Met Ala Gly Ala Leu Asn Arg Lys Glu Ser 
        35                  40                  45              


Phe Leu Leu Leu Ser Leu His Asn Arg Leu Arg Ser Trp Val Gln Pro 
    50                  55                  60                  


Pro Ala Ala Asp Met Arg Arg Leu Asp Trp Ser Asp Ser Leu Ala Gln 
65                  70                  75                  80  


Leu Ala Gln Ala Arg Ala Ala Leu Cys Gly Thr Pro Thr Pro Ser Leu 
                85                  90                  95      


Ala Ser Gly Leu Trp Arg Thr Leu Gln Val Gly Trp Asn Met Gln Leu 
            100                 105                 110         


Leu Pro Ala Gly Leu Val Ser Phe Val Glu Val Val Ser Leu Trp Phe 
        115                 120                 125             


Ala Glu Gly Gln Arg Tyr Ser His Ala Ala Gly Glu Cys Ala Arg Asn 
    130                 135                 140                 


Ala Thr Cys Thr His Tyr Thr Gln Leu Val Trp Ala Thr Ser Ser Gln 
145                 150                 155                 160 


Leu Gly Cys Gly Arg His Leu Cys Ser Ala Gly Gln Ala Ala Ile Glu 
                165                 170                 175     


Ala Phe Val Cys Ala Tyr Ser Pro Arg Gly Asn Trp Glu Val Asn Gly 
            180                 185                 190         


Lys Thr Ile Val Pro Tyr Lys Lys Gly Ala Trp Cys Ser Leu Cys Thr 
        195                 200                 205             


Ala Ser Val Ser Gly Cys Phe Lys Ala Trp Asp His Ala Gly Gly Leu 
    210                 215                 220                 


Cys Glu Val Pro Arg Asn Pro Cys Arg Met Ser Cys Gln Asn His Gly 
225                 230                 235                 240 


Arg Leu Asn Ile Ser Thr Cys His Cys His Cys Pro Pro Gly Tyr Thr 
                245                 250                 255     


Gly Arg Tyr Cys Gln Val Arg Cys Ser Leu Gln Cys Val His Gly Arg 
            260                 265                 270         


Phe Arg Glu Glu Glu Cys Ser Cys Val Cys Asp Ile Gly Tyr Gly Gly 
        275                 280                 285             


Ala Gln Cys Ala Thr Lys Val His Phe Pro Phe His Thr Cys Asp Leu 
    290                 295                 300                 


Arg Ile Asp Gly Asp Cys Phe Met Val Ser Ser Glu Ala Asp Thr Tyr 
305                 310                 315                 320 


Tyr Arg Ala Arg Met Lys Cys Gln Arg Lys Gly Gly Val Leu Ala Gln 
                325                 330                 335     


Ile Lys Ser Gln Lys Val Gln Asp Ile Leu Ala Phe Tyr Leu Gly Arg 
            340                 345                 350         


Leu Glu Thr Thr Asn Glu Val Ile Asp Ser Asp Phe Glu Thr Arg Asn 
        355                 360                 365             


Phe Trp Ile Gly Leu Thr Tyr Lys Thr Ala Lys Asp Ser Phe Arg Trp 
    370                 375                 380                 


Ala Thr Gly Glu His Gln Ala Phe Thr Ser Phe Ala Phe Gly Gln Pro 
385                 390                 395                 400 


Asp Asn His Gly Phe Gly Asn Cys Val Glu Leu Gln Ala Ser Ala Ala 
                405                 410                 415     


Phe Asn Trp Asn Asp Gln Arg Cys Lys Thr Arg Asn Arg Tyr Ile Cys 
            420                 425                 430         


Gln Phe Ala Gln Glu His Ile Ser Arg Trp Gly Pro Gly Ser 
        435                 440                 445     


<210>  3007
<211>  446
<212>  PRT
<213>  Homo Sapiens

<400>  3007

Met Leu His Pro Glu Thr Ser Pro Gly Arg Gly His Leu Leu Ala Val 
1               5                   10                  15      


Leu Leu Ala Leu Leu Gly Thr Ala Trp Ala Glu Val Trp Pro Pro Gln 
            20                  25                  30          


Leu Gln Glu Gln Ala Pro Met Ala Gly Ala Leu Asn Arg Lys Glu Ser 
        35                  40                  45              


Phe Leu Leu Leu Ser Leu His Asn Arg Leu Arg Ser Trp Val Gln Pro 
    50                  55                  60                  


Pro Ala Ala Asp Met Arg Arg Leu Asp Trp Ser Asp Ser Leu Ala Gln 
65                  70                  75                  80  


Leu Ala Gln Ala Arg Ala Ala Leu Cys Gly Thr Pro Thr Pro Ser Leu 
                85                  90                  95      


Ala Ser Gly Leu Trp Arg Thr Leu Gln Val Gly Trp Asn Met Gln Leu 
            100                 105                 110         


Leu Pro Ala Gly Leu Val Ser Phe Val Glu Val Val Ser Leu Trp Phe 
        115                 120                 125             


Ala Glu Gly Gln Arg Tyr Ser His Ala Ala Gly Glu Cys Ala Arg Asn 
    130                 135                 140                 


Ala Thr Cys Thr His Tyr Thr Gln Leu Val Trp Ala Thr Ser Ser Gln 
145                 150                 155                 160 


Leu Gly Cys Gly Arg His Leu Cys Ser Ala Gly Gln Ala Ala Ile Glu 
                165                 170                 175     


Ala Phe Val Cys Ala Tyr Ser Pro Arg Gly Asn Trp Glu Val Asn Gly 
            180                 185                 190         


Lys Thr Ile Val Pro Tyr Lys Lys Gly Ala Trp Cys Ser Leu Cys Thr 
        195                 200                 205             


Ala Ser Val Ser Gly Cys Phe Lys Ala Trp Asp His Ala Gly Gly Leu 
    210                 215                 220                 


Cys Glu Val Pro Arg Asn Pro Cys Arg Met Ser Cys Gln Asn His Gly 
225                 230                 235                 240 


Arg Leu Asn Ile Ser Thr Cys His Cys His Cys Pro Pro Gly Tyr Thr 
                245                 250                 255     


Gly Arg Tyr Cys Gln Val Arg Cys Ser Leu Gln Cys Val His Gly Arg 
            260                 265                 270         


Phe Arg Glu Glu Glu Cys Ser Cys Val Cys Asp Ile Gly Tyr Gly Gly 
        275                 280                 285             


Ala Gln Cys Ala Thr Lys Val His Phe Pro Phe His Thr Cys Asp Leu 
    290                 295                 300                 


Arg Ile Asp Gly Asp Cys Phe Met Val Ser Ser Glu Ala Asp Thr Tyr 
305                 310                 315                 320 


Tyr Arg Ala Arg Met Lys Cys Gln Arg Lys Gly Gly Val Leu Ala Gln 
                325                 330                 335     


Ile Lys Ser Gln Lys Val Gln Asp Ile Leu Ala Phe Tyr Leu Gly Arg 
            340                 345                 350         


Leu Glu Thr Thr Asn Glu Val Ile Asp Ser Asp Phe Glu Thr Arg Asn 
        355                 360                 365             


Phe Trp Ile Gly Leu Thr Tyr Lys Thr Ala Lys Asp Ser Phe Arg Trp 
    370                 375                 380                 


Ala Thr Gly Glu His Gln Ala Phe Thr Ser Phe Ala Phe Gly Gln Pro 
385                 390                 395                 400 


Asp Asn His Gly Phe Gly Asn Cys Val Glu Leu Gln Ala Ser Ala Ala 
                405                 410                 415     


Phe Asn Trp Asn Asp Gln Arg Cys Lys Thr Arg Asn Arg Tyr Ile Cys 
            420                 425                 430         


Gln Phe Ala Gln Glu His Ile Ser Arg Trp Gly Pro Gly Ser 
        435                 440                 445     


<210>  3008
<211>  455
<212>  PRT
<213>  Homo Sapiens

<400>  3008

Met Leu His Pro Glu Thr Ser Pro Gly Arg Gly His Leu Leu Ala Val 
1               5                   10                  15      


Leu Leu Ala Leu Leu Gly Thr Ala Trp Ala Glu Val Trp Pro Pro Gln 
            20                  25                  30          


Leu Gln Glu Gln Ala Pro Met Ala Gly Ala Leu Asn Arg Lys Glu Ser 
        35                  40                  45              


Phe Leu Leu Leu Ser Leu His Asn Arg Leu Arg Ser Trp Val Gln Pro 
    50                  55                  60                  


Pro Ala Ala Asp Met Arg Arg Leu Asp Trp Ser Asp Ser Leu Ala Gln 
65                  70                  75                  80  


Leu Ala Gln Ala Arg Ala Ala Leu Cys Gly Thr Pro Thr Pro Ser Leu 
                85                  90                  95      


Ala Ser Gly Leu Trp Arg Thr Leu Gln Val Gly Trp Asn Met Gln Leu 
            100                 105                 110         


Leu Pro Ala Gly Leu Val Ser Phe Val Glu Val Val Ser Leu Trp Phe 
        115                 120                 125             


Ala Glu Gly Gln Arg Tyr Ser His Ala Ala Gly Glu Cys Ala Arg Asn 
    130                 135                 140                 


Ala Thr Cys Thr His Tyr Thr Gln Leu Val Trp Ala Thr Ser Ser Gln 
145                 150                 155                 160 


Leu Gly Cys Gly Arg His Leu Cys Ser Ala Gly Gln Ala Ala Ile Glu 
                165                 170                 175     


Ala Phe Val Cys Ala Tyr Ser Pro Arg Gly Asn Trp Glu Val Asn Gly 
            180                 185                 190         


Lys Thr Ile Val Pro Tyr Lys Lys Gly Ala Trp Cys Ser Leu Cys Thr 
        195                 200                 205             


Ala Ser Val Ser Gly Cys Phe Lys Ala Trp Asp His Ala Gly Gly Leu 
    210                 215                 220                 


Cys Glu Val Pro Arg Asn Pro Cys Arg Met Ser Cys Gln Asn His Gly 
225                 230                 235                 240 


Arg Leu Asn Ile Ser Thr Cys His Cys His Cys Pro Pro Gly Tyr Thr 
                245                 250                 255     


Gly Arg Tyr Cys Gln Val Arg Cys Ser Leu Gln Cys Val His Gly Arg 
            260                 265                 270         


Phe Arg Glu Glu Glu Cys Ser Cys Val Cys Asp Ile Gly Tyr Gly Gly 
        275                 280                 285             


Ala Gln Cys Ala Thr Lys Val His Phe Pro Phe His Thr Cys Asp Leu 
    290                 295                 300                 


Arg Ile Asp Gly Asp Cys Phe Met Val Ser Ser Glu Ala Asp Thr Tyr 
305                 310                 315                 320 


Tyr Arg Ala Arg Met Lys Cys Gln Arg Lys Gly Gly Val Leu Ala Gln 
                325                 330                 335     


Ile Lys Ser Gln Lys Val Gln Asp Ile Leu Ala Phe Tyr Leu Gly Arg 
            340                 345                 350         


Leu Glu Thr Thr Asn Glu Val Ile Asp Ser Asp Phe Glu Thr Arg Asn 
        355                 360                 365             


Phe Trp Ile Gly Leu Thr Tyr Lys Thr Ala Lys Asp Ser Phe Arg Trp 
    370                 375                 380                 


Ala Thr Gly Glu His Gln Ala Phe Thr Ser Phe Ala Phe Gly Gln Pro 
385                 390                 395                 400 


Asp Asn His Gly Leu Val Trp Leu Ser Ala Ala Met Gly Phe Gly Asn 
                405                 410                 415     


Cys Val Glu Leu Gln Ala Ser Ala Ala Phe Asn Trp Asn Asp Gln Arg 
            420                 425                 430         


Cys Lys Thr Arg Asn Arg Tyr Ile Cys Gln Phe Ala Gln Glu His Ile 
        435                 440                 445             


Ser Arg Trp Gly Pro Gly Ser 
    450                 455 


<210>  3009
<211>  446
<212>  PRT
<213>  Homo Sapiens

<400>  3009

Met Leu His Pro Glu Thr Ser Pro Gly Arg Gly His Leu Leu Ala Val 
1               5                   10                  15      


Leu Leu Ala Leu Leu Gly Thr Ala Trp Ala Glu Val Trp Pro Pro Gln 
            20                  25                  30          


Leu Gln Glu Gln Ala Pro Met Ala Gly Ala Leu Asn Arg Lys Glu Ser 
        35                  40                  45              


Phe Leu Leu Leu Ser Leu His Asn Arg Leu Arg Ser Trp Val Gln Pro 
    50                  55                  60                  


Pro Ala Ala Asp Met Arg Arg Leu Asp Trp Ser Asp Ser Leu Ala Gln 
65                  70                  75                  80  


Leu Ala Gln Ala Arg Ala Ala Leu Cys Gly Thr Pro Thr Pro Ser Leu 
                85                  90                  95      


Ala Ser Gly Leu Trp Arg Thr Leu Gln Val Gly Trp Asn Met Gln Leu 
            100                 105                 110         


Leu Pro Ala Gly Leu Val Ser Phe Val Glu Val Val Ser Leu Trp Phe 
        115                 120                 125             


Ala Glu Gly Gln Arg Tyr Ser His Ala Ala Gly Glu Cys Ala Arg Asn 
    130                 135                 140                 


Ala Thr Cys Thr His Tyr Thr Gln Leu Val Trp Ala Thr Ser Ser Gln 
145                 150                 155                 160 


Leu Gly Cys Gly Arg His Leu Cys Ser Ala Gly Gln Ala Ala Ile Glu 
                165                 170                 175     


Ala Phe Val Cys Ala Tyr Ser Pro Arg Gly Asn Trp Glu Val Asn Gly 
            180                 185                 190         


Lys Thr Ile Val Pro Tyr Lys Lys Gly Ala Trp Cys Ser Leu Cys Thr 
        195                 200                 205             


Ala Ser Val Ser Gly Cys Phe Lys Ala Trp Asp His Ala Gly Gly Leu 
    210                 215                 220                 


Cys Glu Val Pro Arg Asn Pro Cys Arg Met Ser Cys Gln Asn His Gly 
225                 230                 235                 240 


Arg Leu Asn Ile Ser Thr Cys His Cys His Cys Pro Pro Gly Tyr Thr 
                245                 250                 255     


Gly Arg Tyr Cys Gln Val Arg Cys Ser Leu Gln Cys Val His Gly Arg 
            260                 265                 270         


Phe Arg Glu Glu Glu Cys Ser Cys Val Cys Asp Ile Gly Tyr Gly Gly 
        275                 280                 285             


Ala Gln Cys Ala Thr Lys Val His Phe Pro Phe His Thr Cys Asp Leu 
    290                 295                 300                 


Arg Ile Asp Gly Asp Cys Phe Met Val Ser Ser Glu Ala Asp Thr Tyr 
305                 310                 315                 320 


Tyr Arg Ala Arg Met Lys Cys Gln Arg Lys Gly Gly Val Leu Ala Gln 
                325                 330                 335     


Ile Lys Ser Gln Lys Val Gln Asp Ile Leu Ala Phe Tyr Leu Gly Arg 
            340                 345                 350         


Leu Glu Thr Thr Asn Glu Val Ile Asp Ser Asp Phe Glu Thr Arg Asn 
        355                 360                 365             


Phe Trp Ile Gly Leu Thr Tyr Lys Thr Ala Lys Asp Ser Phe Arg Trp 
    370                 375                 380                 


Ala Thr Gly Glu His Gln Ala Phe Thr Ser Phe Ala Phe Gly Gln Pro 
385                 390                 395                 400 


Asp Asn His Gly Phe Gly Asn Cys Val Glu Leu Gln Ala Ser Ala Ala 
                405                 410                 415     


Phe Asn Trp Asn Asp Gln Arg Cys Lys Thr Arg Asn Arg Tyr Ile Cys 
            420                 425                 430         


Gln Phe Ala Gln Glu His Ile Ser Arg Trp Gly Pro Gly Ser 
        435                 440                 445     


<210>  3010
<211>  446
<212>  PRT
<213>  Homo Sapiens

<400>  3010

Met Leu His Pro Glu Thr Ser Pro Gly Arg Gly His Leu Leu Ala Val 
1               5                   10                  15      


Leu Leu Ala Leu Leu Gly Thr Ala Trp Ala Glu Val Trp Pro Pro Gln 
            20                  25                  30          


Leu Gln Glu Gln Ala Pro Met Ala Gly Ala Leu Asn Arg Lys Glu Ser 
        35                  40                  45              


Phe Leu Leu Leu Ser Leu His Asn Arg Leu Arg Ser Trp Val Gln Pro 
    50                  55                  60                  


Pro Ala Ala Asp Met Arg Arg Leu Asp Trp Ser Asp Ser Leu Ala Gln 
65                  70                  75                  80  


Leu Ala Gln Ala Arg Ala Ala Leu Cys Gly Thr Pro Thr Pro Ser Leu 
                85                  90                  95      


Ala Ser Gly Leu Trp Arg Thr Leu Gln Val Gly Trp Asn Met Gln Leu 
            100                 105                 110         


Leu Pro Ala Gly Leu Val Ser Phe Val Glu Val Val Ser Leu Trp Phe 
        115                 120                 125             


Ala Glu Gly Gln Arg Tyr Ser His Ala Ala Gly Glu Cys Ala Arg Asn 
    130                 135                 140                 


Ala Thr Cys Thr His Tyr Thr Gln Leu Val Trp Ala Thr Ser Ser Gln 
145                 150                 155                 160 


Leu Gly Cys Gly Arg His Leu Cys Ser Ala Gly Gln Ala Ala Ile Glu 
                165                 170                 175     


Ala Phe Val Cys Ala Tyr Ser Pro Arg Gly Asn Trp Glu Val Asn Gly 
            180                 185                 190         


Lys Thr Ile Val Pro Tyr Lys Lys Gly Ala Trp Cys Ser Leu Cys Thr 
        195                 200                 205             


Ala Ser Val Ser Gly Cys Phe Lys Ala Trp Asp His Ala Gly Gly Leu 
    210                 215                 220                 


Cys Glu Val Pro Arg Asn Pro Cys Arg Met Ser Cys Gln Asn His Gly 
225                 230                 235                 240 


Arg Leu Asn Ile Ser Thr Cys His Cys His Cys Pro Pro Gly Tyr Thr 
                245                 250                 255     


Gly Arg Tyr Cys Gln Val Arg Cys Ser Leu Gln Cys Val His Gly Arg 
            260                 265                 270         


Phe Arg Glu Glu Glu Cys Ser Cys Val Cys Asp Ile Gly Tyr Gly Gly 
        275                 280                 285             


Ala Gln Cys Ala Thr Lys Val His Phe Pro Phe His Thr Cys Asp Leu 
    290                 295                 300                 


Arg Ile Asp Gly Asp Cys Phe Met Val Ser Ser Glu Ala Asp Thr Tyr 
305                 310                 315                 320 


Tyr Arg Ala Arg Met Lys Cys Gln Arg Lys Gly Gly Val Leu Ala Gln 
                325                 330                 335     


Ile Lys Ser Gln Lys Val Gln Asp Ile Leu Ala Phe Tyr Leu Gly Arg 
            340                 345                 350         


Leu Glu Thr Thr Asn Glu Val Ile Asp Ser Asp Phe Glu Thr Arg Asn 
        355                 360                 365             


Phe Trp Ile Gly Leu Thr Tyr Lys Thr Ala Lys Asp Ser Phe Arg Trp 
    370                 375                 380                 


Ala Thr Gly Glu His Gln Ala Phe Thr Ser Phe Ala Phe Gly Gln Pro 
385                 390                 395                 400 


Asp Asn His Gly Phe Gly Asn Cys Val Glu Leu Gln Ala Ser Ala Ala 
                405                 410                 415     


Phe Asn Trp Asn Asp Gln Arg Cys Lys Thr Arg Asn Arg Tyr Ile Cys 
            420                 425                 430         


Gln Phe Ala Gln Glu His Ile Ser Arg Trp Gly Pro Gly Ser 
        435                 440                 445     


<210>  3011
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  3011

Met Arg Arg Leu Leu Val Trp Ala Thr Ser Ser Gln Leu Gly Cys Gly 
1               5                   10                  15      


Arg His Leu Cys Ser Ala Gly Gln Ala Ala Ile Glu Ala Phe Val Cys 
            20                  25                  30          


Ala Tyr Ser Pro Arg Gly Asn Trp Glu Val Asn Gly Lys Thr Ile Val 
        35                  40                  45              


Pro Tyr Lys Lys Gly Ala Trp Cys Ser Leu Cys Thr Ala Ser Val Ser 
    50                  55                  60                  


Gly Cys 
65      


<210>  3012
<211>  455
<212>  PRT
<213>  Homo Sapiens

<400>  3012

Met Leu His Pro Glu Thr Ser Pro Gly Arg Gly His Leu Leu Ala Val 
1               5                   10                  15      


Leu Leu Ala Leu Leu Gly Thr Thr Trp Ala Glu Val Trp Pro Pro Gln 
            20                  25                  30          


Leu Gln Glu Gln Ala Pro Met Ala Gly Ala Leu Asn Arg Lys Glu Ser 
        35                  40                  45              


Phe Leu Leu Leu Ser Leu His Asn Arg Leu Arg Ser Trp Val Gln Pro 
    50                  55                  60                  


Pro Ala Ala Asp Met Arg Arg Leu Asp Trp Ser Asp Ser Leu Ala Gln 
65                  70                  75                  80  


Leu Ala Gln Ala Arg Ala Ala Leu Cys Gly Ile Pro Thr Pro Ser Leu 
                85                  90                  95      


Ala Ser Gly Leu Trp Arg Thr Leu Gln Val Gly Trp Asn Met Gln Leu 
            100                 105                 110         


Leu Pro Ala Gly Leu Ala Ser Phe Val Glu Val Val Ser Leu Trp Phe 
        115                 120                 125             


Ala Glu Gly Gln Arg Tyr Ser His Ala Ala Gly Glu Cys Ala Arg Asn 
    130                 135                 140                 


Ala Thr Cys Thr His Tyr Thr Gln Leu Val Trp Ala Thr Ser Ser Gln 
145                 150                 155                 160 


Leu Gly Cys Gly Arg His Leu Cys Ser Ala Gly Gln Thr Ala Ile Glu 
                165                 170                 175     


Ala Phe Val Cys Ala Tyr Ser Pro Gly Gly Asn Trp Glu Val Asn Gly 
            180                 185                 190         


Lys Thr Ile Ile Pro Tyr Lys Lys Gly Ala Trp Cys Ser Leu Cys Thr 
        195                 200                 205             


Ala Ser Val Ser Gly Cys Phe Lys Ala Trp Asp His Ala Gly Gly Leu 
    210                 215                 220                 


Cys Glu Val Pro Arg Asn Pro Cys Arg Met Ser Cys Gln Asn His Gly 
225                 230                 235                 240 


Arg Leu Asn Ile Ser Thr Cys His Cys His Cys Pro Pro Gly Tyr Thr 
                245                 250                 255     


Gly Arg Tyr Cys Gln Val Arg Cys Ser Leu Gln Cys Val His Gly Arg 
            260                 265                 270         


Phe Arg Glu Glu Glu Cys Ser Cys Val Cys Asp Ile Gly Tyr Gly Gly 
        275                 280                 285             


Ala Gln Cys Ala Thr Lys Val His Phe Pro Phe His Thr Cys Asp Leu 
    290                 295                 300                 


Arg Ile Asp Gly Asp Cys Phe Met Val Ser Ser Glu Ala Asp Thr Tyr 
305                 310                 315                 320 


Tyr Arg Ala Arg Met Lys Cys Gln Arg Lys Gly Gly Val Leu Ala Gln 
                325                 330                 335     


Ile Lys Ser Gln Lys Val Gln Asp Ile Leu Ala Phe Tyr Leu Gly Arg 
            340                 345                 350         


Leu Glu Thr Thr Asn Glu Val Ile Asp Ser Asp Phe Glu Thr Arg Asn 
        355                 360                 365             


Phe Trp Ile Gly Leu Thr Tyr Lys Thr Ala Lys Asp Ser Phe Arg Trp 
    370                 375                 380                 


Ala Thr Gly Glu His Gln Ala Phe Thr Ser Phe Ala Phe Gly Gln Pro 
385                 390                 395                 400 


Asp Asn His Gly Leu Val Trp Leu Ser Ala Ala Met Gly Phe Gly Asn 
                405                 410                 415     


Cys Val Glu Leu Gln Ala Ser Ala Ala Phe Asn Trp Asn Asp Gln Arg 
            420                 425                 430         


Cys Lys Thr Arg Asn Arg Tyr Ile Cys Gln Phe Ala Gln Glu His Ile 
        435                 440                 445             


Ser Arg Trp Gly Pro Gly Ser 
    450                 455 


<210>  3013
<211>  446
<212>  PRT
<213>  Homo Sapiens

<400>  3013

Met Leu His Pro Glu Thr Ser Pro Gly Arg Gly His Leu Leu Ala Val 
1               5                   10                  15      


Leu Leu Ala Leu Leu Gly Thr Thr Trp Ala Glu Val Trp Pro Pro Gln 
            20                  25                  30          


Leu Gln Glu Gln Ala Pro Met Ala Gly Ala Leu Asn Arg Lys Glu Ser 
        35                  40                  45              


Phe Leu Leu Leu Ser Leu His Asn Arg Leu Arg Ser Trp Val Gln Pro 
    50                  55                  60                  


Pro Ala Ala Asp Met Arg Arg Leu Asp Trp Ser Asp Ser Leu Ala Gln 
65                  70                  75                  80  


Leu Ala Gln Ala Arg Ala Ala Leu Cys Gly Ile Pro Thr Pro Ser Leu 
                85                  90                  95      


Ala Ser Gly Leu Trp Arg Thr Leu Gln Val Gly Trp Asn Met Gln Leu 
            100                 105                 110         


Leu Pro Ala Gly Leu Ala Ser Phe Val Glu Val Val Ser Leu Trp Phe 
        115                 120                 125             


Ala Glu Gly Gln Arg Tyr Ser His Ala Ala Gly Glu Cys Ala Arg Asn 
    130                 135                 140                 


Ala Thr Cys Thr His Tyr Thr Gln Leu Val Trp Ala Thr Ser Ser Gln 
145                 150                 155                 160 


Leu Gly Cys Gly Arg His Leu Cys Ser Ala Gly Gln Thr Ala Ile Glu 
                165                 170                 175     


Ala Phe Val Cys Ala Tyr Ser Pro Arg Gly Asn Trp Glu Val Asn Gly 
            180                 185                 190         


Lys Thr Ile Ile Pro Tyr Lys Lys Gly Ala Trp Cys Ser Leu Cys Thr 
        195                 200                 205             


Ala Ser Val Ser Gly Cys Phe Lys Ala Trp Asp His Ala Gly Gly Leu 
    210                 215                 220                 


Cys Glu Val Pro Arg Asn Pro Cys Arg Met Ser Cys Gln Asn His Gly 
225                 230                 235                 240 


Arg Leu Asn Ile Ser Thr Cys His Cys His Cys Pro Pro Gly Tyr Thr 
                245                 250                 255     


Gly Arg Tyr Cys Gln Val Arg Cys Ser Leu Gln Cys Val His Gly Arg 
            260                 265                 270         


Phe Arg Glu Glu Glu Cys Ser Cys Val Cys Asp Ile Gly Tyr Gly Gly 
        275                 280                 285             


Ala Gln Cys Ala Thr Lys Val His Phe Pro Phe His Thr Cys Asp Leu 
    290                 295                 300                 


Arg Ile Asp Gly Asp Cys Phe Met Val Ser Ser Glu Ala Asp Thr Tyr 
305                 310                 315                 320 


Tyr Arg Ala Arg Met Lys Cys Gln Arg Lys Gly Gly Val Leu Ala Gln 
                325                 330                 335     


Ile Lys Ser Gln Lys Val Gln Asp Ile Leu Ala Phe Tyr Leu Gly Arg 
            340                 345                 350         


Leu Glu Thr Thr Asn Glu Val Ile Asp Ser Asp Phe Glu Thr Arg Asn 
        355                 360                 365             


Phe Trp Ile Gly Leu Thr Tyr Lys Thr Ala Lys Asp Ser Phe Arg Trp 
    370                 375                 380                 


Ala Thr Gly Glu His Gln Ala Phe Thr Ser Phe Ala Phe Gly Gln Pro 
385                 390                 395                 400 


Asp Asn His Gly Phe Gly Asn Cys Val Glu Leu Gln Ala Ser Ala Ala 
                405                 410                 415     


Phe Asn Trp Asn Asp Gln Arg Cys Lys Thr Arg Asn Arg Tyr Ile Cys 
            420                 425                 430         


Gln Phe Ala Gln Glu His Ile Ser Arg Trp Gly Pro Gly Ser 
        435                 440                 445     


<210>  3014
<211>  303
<212>  PRT
<213>  Homo Sapiens

<400>  3014

Met Leu His Pro Glu Thr Ser Pro Gly Arg Gly His Leu Leu Ala Val 
1               5                   10                  15      


Leu Leu Ala Leu Leu Gly Thr Thr Trp Ala Glu Val Trp Pro Pro Gln 
            20                  25                  30          


Leu Gln Glu Gln Ala Pro Met Ala Gly Ala Leu Asn Arg Lys Glu Ser 
        35                  40                  45              


Phe Leu Leu Leu Ser Leu His Asn Arg Leu Arg Ser Trp Val Gln Pro 
    50                  55                  60                  


Pro Ala Ala Asp Met Arg Arg Leu Asp Trp Ser Asp Ser Leu Ala Gln 
65                  70                  75                  80  


Leu Ala Gln Ala Arg Ala Ala Leu Cys Gly Ile Pro Thr Pro Ser Leu 
                85                  90                  95      


Ala Ser Gly Leu Trp Arg Thr Leu Gln Val Gly Trp Asn Met Gln Leu 
            100                 105                 110         


Leu Pro Ala Gly Leu Ala Ser Phe Val Glu Val Val Ser Leu Trp Phe 
        115                 120                 125             


Ala Glu Gly Gln Arg Tyr Ser His Ala Ala Gly Glu Cys Ala Arg Asn 
    130                 135                 140                 


Ala Thr Cys Thr His Tyr Thr Gln Leu Val Trp Ala Thr Ser Ser Gln 
145                 150                 155                 160 


Leu Gly Cys Gly Arg His Leu Cys Ser Ala Gly Gln Thr Ala Ile Glu 
                165                 170                 175     


Ala Phe Val Cys Ala Tyr Ser Pro Arg Gly Asn Trp Glu Val Asn Gly 
            180                 185                 190         


Lys Thr Ile Ile Pro Tyr Lys Lys Gly Ala Trp Cys Ser Leu Cys Thr 
        195                 200                 205             


Ala Ser Val Ser Gly Cys Phe Lys Ala Trp Asp His Ala Gly Gly Leu 
    210                 215                 220                 


Cys Glu Val Pro Arg Asn Pro Cys Arg Met Ser Cys Gln Asn His Gly 
225                 230                 235                 240 


Arg Leu Asn Ile Ser Thr Cys His Cys His Cys Pro Pro Gly Tyr Thr 
                245                 250                 255     


Gly Arg Tyr Cys Gln Val Arg Cys Ser Leu Gln Cys Val His Gly Arg 
            260                 265                 270         


Phe Arg Glu Glu Glu Cys Ser Cys Val Cys Asp Ile Gly Tyr Gly Glu 
        275                 280                 285             


Pro Ser Val Pro Pro Arg Cys Ile Phe Pro Ser Thr Pro Val Thr 
    290                 295                 300             


<210>  3015
<211>  446
<212>  PRT
<213>  Homo Sapiens

<400>  3015

Met Leu His Pro Glu Thr Ser Pro Gly Arg Gly His Leu Leu Ala Val 
1               5                   10                  15      


Leu Leu Ala Leu Leu Gly Thr Thr Trp Ala Glu Val Trp Pro Pro Gln 
            20                  25                  30          


Leu Gln Glu Gln Ala Pro Met Ala Gly Ala Leu Asn Arg Lys Glu Ser 
        35                  40                  45              


Phe Leu Leu Leu Ser Leu His Asn Arg Leu Arg Ser Trp Val Gln Pro 
    50                  55                  60                  


Pro Ala Ala Asp Met Arg Arg Leu Asp Trp Ser Asp Ser Leu Ala Gln 
65                  70                  75                  80  


Leu Ala Gln Ala Arg Ala Ala Leu Cys Gly Ile Pro Thr Pro Ser Leu 
                85                  90                  95      


Ala Ser Gly Leu Trp Arg Thr Leu Gln Val Gly Trp Asn Met Gln Leu 
            100                 105                 110         


Leu Pro Ala Gly Leu Ala Ser Phe Val Glu Val Val Ser Leu Trp Phe 
        115                 120                 125             


Ala Glu Gly Gln Arg Tyr Ser His Ala Ala Gly Glu Cys Ala Arg Asn 
    130                 135                 140                 


Ala Thr Cys Thr His Tyr Thr Gln Leu Val Trp Ala Thr Ser Ser Gln 
145                 150                 155                 160 


Leu Gly Cys Gly Arg His Leu Cys Ser Ala Gly Gln Thr Ala Ile Glu 
                165                 170                 175     


Ala Phe Val Cys Ala Tyr Ser Pro Arg Gly Asn Trp Glu Val Asn Gly 
            180                 185                 190         


Lys Thr Ile Ile Pro Tyr Lys Lys Gly Ala Trp Cys Ser Leu Cys Thr 
        195                 200                 205             


Ala Ser Val Ser Gly Cys Phe Lys Ala Trp Asp His Ala Gly Gly Leu 
    210                 215                 220                 


Cys Glu Val Pro Arg Asn Pro Cys Arg Met Ser Cys Gln Asn His Gly 
225                 230                 235                 240 


Arg Leu Asn Ile Ser Thr Cys His Cys His Cys Pro Pro Gly Tyr Thr 
                245                 250                 255     


Gly Arg Tyr Cys Gln Val Arg Cys Ser Leu Gln Cys Val His Gly Arg 
            260                 265                 270         


Phe Arg Glu Glu Glu Cys Ser Cys Val Cys Asp Ile Gly Tyr Gly Gly 
        275                 280                 285             


Ala Gln Cys Ala Thr Lys Val His Phe Pro Phe His Thr Cys Asp Leu 
    290                 295                 300                 


Arg Ile Asp Gly Asp Cys Phe Met Val Ser Ser Glu Ala Asp Thr Tyr 
305                 310                 315                 320 


Tyr Arg Ala Arg Met Lys Cys Gln Arg Lys Gly Gly Val Leu Ala Gln 
                325                 330                 335     


Ile Lys Ser Gln Lys Val Gln Asp Ile Leu Ala Phe Tyr Leu Gly Arg 
            340                 345                 350         


Leu Glu Thr Thr Asn Glu Val Ile Asp Ser Asp Phe Glu Thr Arg Asn 
        355                 360                 365             


Phe Trp Ile Gly Leu Thr Tyr Lys Thr Ala Lys Asp Ser Phe Arg Trp 
    370                 375                 380                 


Ala Thr Gly Glu His Gln Ala Phe Thr Ser Phe Ala Phe Gly Gln Pro 
385                 390                 395                 400 


Asp Asn His Gly Phe Gly Asn Cys Val Glu Leu Gln Ala Ser Ala Ala 
                405                 410                 415     


Phe Asn Trp Asn Asp Gln Arg Cys Lys Thr Arg Asn Arg Tyr Ile Cys 
            420                 425                 430         


Gln Phe Ala Gln Glu His Ile Ser Arg Trp Gly Pro Gly Ser 
        435                 440                 445     


<210>  3016
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  3016

Met Leu His Pro Glu Thr Ser Pro Gly Arg Gly His Leu Leu Ala Val 
1               5                   10                  15      


Leu Leu Ala Leu Leu Gly Thr Ala Trp Ala Glu Val Trp Pro Pro Gln 
            20                  25                  30          


Leu Gln Glu Gln Ala Pro Met Ala Gly Ala Leu Asn Arg Lys Glu Ser 
        35                  40                  45              


Phe Leu Leu Leu Ser Leu His Asn Arg Leu Arg Ser Trp Val Gln Pro 
    50                  55                  60                  


Pro Ala Ala Asp Met Arg Arg Leu Asp Trp Ser Asp Ser Leu Ala Gln 
65                  70                  75                  80  


Leu Ala Gln Ala Arg Ala Ala Leu Cys Gly Ile Pro Thr Pro Ser Leu 
                85                  90                  95      


Ala Ser Gly Leu Trp Arg Thr Leu Gln Val Gly Trp Asn Met Gln Leu 
            100                 105                 110         


Leu Pro Ala Gly Leu Ala Ser 
        115                 


<210>  3017
<211>  446
<212>  PRT
<213>  Homo Sapiens

<400>  3017

Met Leu His Pro Glu Thr Ser Pro Gly Arg Gly His Leu Leu Ala Val 
1               5                   10                  15      


Leu Leu Ala Leu Leu Gly Thr Ala Trp Ala Glu Val Trp Pro Pro Gln 
            20                  25                  30          


Leu Gln Glu Gln Ala Pro Met Ala Gly Ala Leu Asn Arg Lys Glu Ser 
        35                  40                  45              


Phe Leu Leu Leu Ser Leu His Asn Arg Leu Arg Ser Trp Val Gln Pro 
    50                  55                  60                  


Pro Ala Ala Asp Met Arg Arg Leu Asp Trp Ser Asp Ser Leu Ala Gln 
65                  70                  75                  80  


Leu Ala Gln Ala Arg Ala Ala Leu Cys Gly Ile Pro Thr Pro Ser Leu 
                85                  90                  95      


Ala Ser Gly Leu Trp Arg Thr Leu Gln Val Gly Trp Asn Met Gln Leu 
            100                 105                 110         


Leu Pro Ala Gly Leu Ala Ser Phe Val Glu Val Val Ser Leu Trp Phe 
        115                 120                 125             


Ala Glu Gly Gln Arg Tyr Ser His Ala Ala Gly Glu Cys Ala Arg Asn 
    130                 135                 140                 


Ala Thr Cys Thr His Tyr Thr Gln Leu Val Trp Ala Thr Ser Ser Gln 
145                 150                 155                 160 


Leu Gly Cys Gly Arg His Leu Cys Ser Ala Gly Gln Ala Ala Ile Glu 
                165                 170                 175     


Ala Phe Val Cys Ala Tyr Ser Pro Arg Gly Asn Trp Glu Val Asn Gly 
            180                 185                 190         


Lys Thr Ile Val Pro Tyr Lys Lys Gly Ala Trp Cys Ser Leu Cys Thr 
        195                 200                 205             


Ala Ser Val Ser Gly Cys Phe Lys Ala Trp Asp His Ala Gly Gly Leu 
    210                 215                 220                 


Cys Glu Val Pro Arg Asn Pro Cys Arg Met Ser Cys Gln Asn His Gly 
225                 230                 235                 240 


Arg Leu Asn Ile Ser Thr Cys His Cys His Cys Pro Pro Gly Tyr Thr 
                245                 250                 255     


Gly Arg Tyr Cys Gln Val Arg Cys Ser Leu Gln Cys Val His Gly Arg 
            260                 265                 270         


Phe Arg Glu Glu Glu Cys Ser Cys Val Cys Asp Ile Gly Tyr Gly Gly 
        275                 280                 285             


Ala Gln Cys Ala Thr Lys Val His Phe Pro Phe His Thr Cys Asp Leu 
    290                 295                 300                 


Arg Ile Asp Gly Asp Cys Phe Met Val Ser Ser Glu Ala Asp Thr Tyr 
305                 310                 315                 320 


Tyr Arg Ala Arg Met Lys Cys Gln Arg Lys Gly Gly Val Leu Ala Gln 
                325                 330                 335     


Ile Lys Ser Gln Lys Val Gln Asp Ile Leu Ala Phe Tyr Leu Gly Arg 
            340                 345                 350         


Leu Glu Thr Thr Asn Glu Val Ile Asp Ser Asp Phe Glu Thr Arg Asn 
        355                 360                 365             


Phe Trp Ile Gly Leu Thr Tyr Lys Thr Ala Lys Asp Ser Phe Arg Trp 
    370                 375                 380                 


Ala Thr Gly Glu His Gln Ala Phe Thr Ser Phe Ala Phe Gly Gln Pro 
385                 390                 395                 400 


Asp Asn His Gly Phe Gly Asn Cys Val Glu Leu Gln Ala Ser Ala Ala 
                405                 410                 415     


Phe Asn Trp Asn Asn Gln Arg Cys Lys Thr Arg Asn Arg Tyr Ile Cys 
            420                 425                 430         


Gln Phe Ala Gln Glu His Ile Ser Arg Trp Gly Pro Gly Ser 
        435                 440                 445     


<210>  3018
<211>  455
<212>  PRT
<213>  Homo Sapiens

<400>  3018

Met Leu His Pro Glu Thr Ser Pro Gly Arg Gly His Leu Leu Ala Val 
1               5                   10                  15      


Leu Leu Ala Leu Leu Gly Thr Ala Trp Ala Glu Val Trp Pro Pro Gln 
            20                  25                  30          


Leu Gln Glu Gln Ala Pro Met Ala Gly Ala Leu Asn Arg Lys Glu Ser 
        35                  40                  45              


Phe Leu Leu Leu Ser Leu His Asn Arg Leu Arg Ser Trp Val Gln Pro 
    50                  55                  60                  


Pro Ala Ala Asp Met Arg Arg Leu Asp Trp Ser Asp Ser Leu Ala Gln 
65                  70                  75                  80  


Leu Ala Gln Ala Arg Ala Ala Leu Cys Gly Ile Pro Thr Pro Ser Leu 
                85                  90                  95      


Ala Ser Gly Leu Trp Arg Thr Leu Gln Val Gly Trp Asn Met Gln Leu 
            100                 105                 110         


Leu Pro Ala Gly Leu Ala Ser Phe Val Glu Val Val Ser Leu Trp Phe 
        115                 120                 125             


Ala Glu Gly Gln Arg Tyr Ser His Ala Ala Gly Glu Cys Ala Arg Asn 
    130                 135                 140                 


Ala Thr Cys Thr His Tyr Thr Gln Leu Val Trp Ala Thr Ser Ser Gln 
145                 150                 155                 160 


Leu Gly Cys Gly Arg His Leu Cys Ser Ala Gly Gln Ala Ala Ile Glu 
                165                 170                 175     


Ala Phe Val Cys Ala Tyr Ser Pro Arg Gly Asn Trp Glu Val Asn Gly 
            180                 185                 190         


Lys Thr Ile Val Pro Tyr Lys Lys Gly Ala Trp Cys Ser Leu Cys Thr 
        195                 200                 205             


Ala Ser Val Ser Gly Cys Phe Lys Ala Trp Asp His Ala Gly Gly Leu 
    210                 215                 220                 


Cys Glu Val Pro Arg Asn Pro Cys Arg Met Ser Cys Gln Asn His Gly 
225                 230                 235                 240 


Arg Leu Asn Ile Ser Thr Cys His Cys His Cys Pro Pro Gly Tyr Thr 
                245                 250                 255     


Gly Arg Tyr Cys Gln Val Arg Cys Ser Leu Gln Cys Val His Gly Arg 
            260                 265                 270         


Phe Arg Glu Glu Glu Cys Ser Cys Val Cys Asp Ile Gly Tyr Gly Gly 
        275                 280                 285             


Ala Gln Cys Ala Thr Lys Val His Phe Pro Phe His Thr Cys Asp Leu 
    290                 295                 300                 


Arg Ile Asp Gly Asp Cys Phe Met Val Ser Ser Glu Ala Asp Thr Tyr 
305                 310                 315                 320 


Tyr Arg Ala Arg Met Lys Cys Gln Arg Lys Gly Gly Val Leu Ala Gln 
                325                 330                 335     


Ile Lys Ser Gln Lys Val Gln Asp Ile Leu Ala Phe Tyr Leu Gly Arg 
            340                 345                 350         


Leu Glu Thr Thr Asn Glu Val Ile Asp Ser Asp Phe Glu Thr Arg Asn 
        355                 360                 365             


Phe Trp Ile Gly Leu Thr Tyr Lys Thr Ala Lys Asp Ser Phe Arg Trp 
    370                 375                 380                 


Ala Thr Gly Glu His Gln Ala Phe Thr Ser Phe Ala Phe Gly Gln Pro 
385                 390                 395                 400 


Asp Asn His Gly Leu Val Trp Leu Ser Ala Ala Met Gly Phe Gly Asn 
                405                 410                 415     


Cys Val Glu Leu Gln Ala Ser Ala Ala Phe Asn Trp Asn Asn Gln Arg 
            420                 425                 430         


Cys Lys Thr Arg Asn Arg Tyr Ile Cys Gln Phe Ala Gln Glu His Ile 
        435                 440                 445             


Ser Arg Trp Gly Pro Gly Ser 
    450                 455 


<210>  3019
<211>  446
<212>  PRT
<213>  Homo Sapiens

<400>  3019

Met Leu His Pro Glu Thr Ser Pro Gly Arg Gly His Leu Leu Ala Val 
1               5                   10                  15      


Leu Leu Ala Leu Leu Gly Thr Ala Trp Ala Glu Val Trp Pro Pro Gln 
            20                  25                  30          


Leu Gln Glu Gln Ala Pro Met Ala Gly Ala Leu Asn Arg Lys Glu Ser 
        35                  40                  45              


Phe Leu Leu Leu Ser Leu His Asn Arg Leu Arg Ser Trp Val Gln Pro 
    50                  55                  60                  


Pro Ala Ala Asp Met Arg Arg Leu Asp Trp Ser Asp Ser Leu Ala Gln 
65                  70                  75                  80  


Leu Ala Gln Ala Arg Ala Ala Leu Cys Gly Ile Pro Thr Pro Ser Leu 
                85                  90                  95      


Ala Ser Gly Leu Trp Arg Thr Leu Gln Val Gly Trp Asn Met Gln Leu 
            100                 105                 110         


Leu Pro Ala Gly Leu Ala Ser Phe Val Glu Val Val Ser Leu Trp Phe 
        115                 120                 125             


Ala Glu Gly Gln Arg Tyr Ser His Ala Ala Gly Glu Cys Ala Arg Asn 
    130                 135                 140                 


Ala Thr Cys Thr His Tyr Thr Gln Leu Val Trp Ala Thr Ser Ser Gln 
145                 150                 155                 160 


Leu Gly Cys Gly Arg His Leu Cys Ser Ala Gly Gln Ala Ala Ile Glu 
                165                 170                 175     


Ala Phe Val Cys Ala Tyr Ser Pro Arg Gly Asn Trp Glu Val Asn Gly 
            180                 185                 190         


Lys Thr Ile Val Pro Tyr Lys Lys Gly Ala Trp Cys Ser Leu Cys Thr 
        195                 200                 205             


Ala Ser Val Ser Gly Cys Phe Lys Ala Trp Asp His Ala Gly Gly Leu 
    210                 215                 220                 


Cys Glu Val Pro Arg Asn Pro Cys Arg Met Ser Cys Gln Asn His Gly 
225                 230                 235                 240 


Arg Leu Asn Ile Ser Thr Cys His Cys His Cys Pro Pro Gly Tyr Thr 
                245                 250                 255     


Gly Arg Tyr Cys Gln Val Arg Cys Ser Leu Gln Cys Val His Gly Arg 
            260                 265                 270         


Phe Arg Glu Glu Glu Cys Ser Cys Val Cys Asp Ile Gly Tyr Gly Gly 
        275                 280                 285             


Ala Gln Cys Ala Thr Lys Val His Phe Pro Phe His Thr Cys Asp Leu 
    290                 295                 300                 


Arg Ile Asp Gly Asp Cys Phe Met Val Ser Ser Glu Ala Asp Thr Tyr 
305                 310                 315                 320 


Tyr Arg Ala Arg Met Lys Cys Gln Arg Lys Gly Gly Val Leu Ala Gln 
                325                 330                 335     


Ile Lys Ser Gln Lys Val Gln Asp Ile Leu Ala Phe Tyr Leu Gly Arg 
            340                 345                 350         


Leu Glu Thr Thr Asn Glu Val Ile Asp Ser Asp Phe Glu Thr Arg Asn 
        355                 360                 365             


Phe Trp Ile Gly Leu Thr Tyr Lys Thr Ala Lys Asp Ser Phe Arg Trp 
    370                 375                 380                 


Ala Thr Gly Glu His Gln Ala Phe Thr Ser Phe Ala Phe Gly Gln Pro 
385                 390                 395                 400 


Asp Asn His Gly Phe Gly Asn Cys Val Glu Leu Gln Ala Ser Ala Ala 
                405                 410                 415     


Phe Asn Trp Asn Asn Gln Arg Cys Lys Thr Arg Asn Arg Tyr Ile Cys 
            420                 425                 430         


Gln Phe Ala Gln Glu His Ile Ser Arg Trp Gly Pro Gly Ser 
        435                 440                 445     


<210>  3020
<211>  446
<212>  PRT
<213>  Homo Sapiens

<400>  3020

Met Leu His Pro Glu Thr Ser Pro Gly Arg Gly His Leu Leu Ala Val 
1               5                   10                  15      


Leu Leu Ala Leu Leu Gly Thr Ala Trp Ala Glu Val Trp Pro Pro Gln 
            20                  25                  30          


Leu Gln Glu Gln Ala Pro Met Ala Gly Ala Leu Asn Arg Lys Glu Ser 
        35                  40                  45              


Phe Leu Leu Leu Ser Leu His Asn Arg Leu Arg Ser Trp Val Gln Pro 
    50                  55                  60                  


Pro Ala Ala Asp Met Arg Arg Leu Asp Trp Ser Asp Ser Leu Ala Gln 
65                  70                  75                  80  


Leu Ala Gln Ala Arg Ala Ala Leu Cys Gly Ile Pro Thr Pro Ser Leu 
                85                  90                  95      


Ala Ser Gly Leu Trp Arg Thr Leu Gln Val Gly Trp Asn Met Gln Leu 
            100                 105                 110         


Leu Pro Ala Gly Leu Ala Ser Phe Val Glu Val Val Ser Leu Trp Phe 
        115                 120                 125             


Ala Glu Gly Gln Arg Tyr Ser His Ala Ala Gly Glu Cys Ala Arg Asn 
    130                 135                 140                 


Ala Thr Cys Thr His Tyr Thr Gln Leu Val Trp Ala Thr Ser Ser Gln 
145                 150                 155                 160 


Leu Gly Cys Gly Arg His Leu Cys Ser Ala Gly Gln Ala Ala Ile Glu 
                165                 170                 175     


Ala Phe Val Cys Ala Tyr Ser Pro Arg Gly Asn Trp Glu Val Asn Gly 
            180                 185                 190         


Lys Thr Ile Val Pro Tyr Lys Lys Gly Ala Trp Cys Ser Leu Cys Thr 
        195                 200                 205             


Ala Ser Val Ser Gly Cys Phe Lys Ala Trp Asp His Ala Gly Gly Leu 
    210                 215                 220                 


Cys Glu Val Pro Arg Asn Pro Cys Arg Met Ser Cys Gln Asn His Gly 
225                 230                 235                 240 


Arg Leu Asn Ile Ser Thr Cys His Cys His Cys Pro Pro Gly Tyr Thr 
                245                 250                 255     


Gly Arg Tyr Cys Gln Val Arg Cys Ser Leu Gln Cys Val His Gly Arg 
            260                 265                 270         


Phe Arg Glu Glu Glu Cys Ser Cys Val Cys Asp Ile Gly Tyr Gly Gly 
        275                 280                 285             


Ala Gln Cys Ala Thr Lys Val His Phe Pro Phe His Thr Cys Asp Leu 
    290                 295                 300                 


Arg Ile Asp Gly Asp Cys Phe Met Val Ser Ser Glu Ala Asp Thr Tyr 
305                 310                 315                 320 


Tyr Arg Ala Arg Met Lys Cys Gln Arg Lys Gly Gly Val Leu Ala Gln 
                325                 330                 335     


Ile Lys Ser Gln Lys Val Gln Asp Ile Leu Ala Phe Tyr Leu Gly Arg 
            340                 345                 350         


Leu Glu Thr Thr Asn Glu Val Ile Asp Ser Asp Phe Glu Thr Arg Asn 
        355                 360                 365             


Phe Trp Ile Gly Leu Thr Tyr Lys Thr Ala Lys Asp Ser Phe Arg Trp 
    370                 375                 380                 


Ala Thr Gly Glu His Gln Ala Phe Thr Ser Phe Ala Phe Gly Gln Pro 
385                 390                 395                 400 


Asp Asn His Gly Phe Gly Asn Cys Val Glu Leu Gln Ala Ser Ala Ala 
                405                 410                 415     


Phe Asn Trp Asn Asn Gln Arg Cys Lys Thr Arg Asn Arg Tyr Ile Cys 
            420                 425                 430         


Gln Phe Ala Gln Glu His Ile Ser Arg Trp Gly Pro Gly Ser 
        435                 440                 445     


<210>  3021
<211>  446
<212>  PRT
<213>  Homo Sapiens

<400>  3021

Met Leu His Pro Glu Thr Ser Pro Gly Arg Gly His Leu Leu Ala Val 
1               5                   10                  15      


Leu Leu Ala Leu Leu Gly Thr Ala Trp Ala Glu Val Trp Pro Pro Gln 
            20                  25                  30          


Leu Gln Glu Gln Ala Pro Met Ala Gly Ala Leu Asn Arg Lys Glu Ser 
        35                  40                  45              


Phe Leu Leu Leu Ser Leu His Asn Arg Leu Arg Ser Trp Val Gln Pro 
    50                  55                  60                  


Pro Ala Ala Asp Met Arg Arg Leu Asp Trp Ser Asp Ser Leu Ala Gln 
65                  70                  75                  80  


Leu Ala Gln Ala Arg Ala Ala Leu Cys Gly Ile Pro Thr Pro Ser Leu 
                85                  90                  95      


Ala Ser Gly Leu Trp Arg Thr Leu Gln Val Gly Trp Asn Met Gln Leu 
            100                 105                 110         


Leu Pro Ala Gly Leu Ala Ser Phe Val Glu Val Val Ser Leu Trp Phe 
        115                 120                 125             


Ala Glu Gly Gln Arg Tyr Ser His Ala Ala Gly Glu Cys Ala Arg Asn 
    130                 135                 140                 


Ala Thr Cys Thr His Tyr Thr Gln Leu Val Trp Ala Thr Ser Ser Gln 
145                 150                 155                 160 


Leu Gly Cys Gly Arg His Leu Cys Ser Ala Gly Gln Ala Ala Ile Glu 
                165                 170                 175     


Ala Phe Val Cys Ala Tyr Ser Pro Arg Gly Asn Trp Glu Val Asn Gly 
            180                 185                 190         


Lys Thr Ile Val Pro Tyr Lys Lys Gly Ala Trp Cys Ser Leu Cys Thr 
        195                 200                 205             


Ala Ser Val Ser Gly Cys Phe Lys Ala Trp Asp His Ala Gly Gly Leu 
    210                 215                 220                 


Cys Glu Val Pro Arg Asn Pro Cys Arg Met Ser Cys Gln Asn His Gly 
225                 230                 235                 240 


Arg Leu Asn Ile Ser Thr Cys His Cys His Cys Pro Pro Gly Tyr Thr 
                245                 250                 255     


Gly Arg Tyr Cys Gln Val Arg Cys Ser Leu Gln Cys Val His Gly Arg 
            260                 265                 270         


Phe Arg Glu Glu Glu Cys Ser Cys Val Cys Asp Ile Gly Tyr Gly Gly 
        275                 280                 285             


Ala Gln Cys Ala Thr Lys Val His Phe Pro Phe His Thr Cys Asp Leu 
    290                 295                 300                 


Arg Ile Asp Gly Asp Cys Phe Met Val Ser Ser Glu Ala Asp Thr Tyr 
305                 310                 315                 320 


Tyr Arg Ala Arg Met Lys Cys Gln Arg Lys Gly Gly Val Leu Ala Gln 
                325                 330                 335     


Ile Lys Ser Gln Lys Val Gln Asp Ile Leu Ala Phe Tyr Leu Gly Arg 
            340                 345                 350         


Leu Glu Thr Thr Asn Glu Val Ile Asp Ser Asp Phe Glu Thr Arg Asn 
        355                 360                 365             


Phe Trp Ile Gly Leu Thr Tyr Lys Thr Ala Lys Asp Ser Phe Arg Trp 
    370                 375                 380                 


Ala Thr Gly Glu His Gln Ala Phe Thr Ser Phe Ala Phe Gly Gln Pro 
385                 390                 395                 400 


Asp Asn His Gly Phe Gly Asn Cys Val Glu Leu Gln Ala Ser Ala Ala 
                405                 410                 415     


Phe Asn Trp Asn Asn Gln Arg Cys Lys Thr Arg Asn Arg Tyr Ile Cys 
            420                 425                 430         


Gln Phe Ala Gln Glu His Ile Ser Arg Trp Gly Pro Gly Ser 
        435                 440                 445     


<210>  3022
<211>  134
<212>  PRT
<213>  Homo Sapiens

<400>  3022

Met Leu His Pro Glu Thr Ser Pro Gly Arg Gly His Leu Leu Ala Val 
1               5                   10                  15      


Leu Leu Ala Leu Leu Gly Thr Ala Trp Ala Glu Val Trp Pro Pro Gln 
            20                  25                  30          


Leu Gln Glu Gln Ala Pro Met Ala Gly Ala Leu Asn Arg Lys Glu Ser 
        35                  40                  45              


Phe Leu Leu Leu Ser Leu His Asn Arg Leu Arg Ser Trp Val Gln Pro 
    50                  55                  60                  


Pro Ala Ala Asp Met Arg Arg Leu Leu Val Trp Ala Thr Ser Ser Gln 
65                  70                  75                  80  


Leu Gly Cys Gly Arg His Leu Cys Ser Ala Gly Gln Ala Ala Ile Glu 
                85                  90                  95      


Ala Phe Val Cys Ala Tyr Ser Pro Arg Gly Asn Trp Glu Val Asn Gly 
            100                 105                 110         


Lys Thr Ile Val Pro Tyr Lys Lys Gly Ala Trp Cys Ser Leu Cys Thr 
        115                 120                 125             


Ala Ser Val Ser Gly Cys 
    130                 


<210>  3023
<211>  86
<212>  PRT
<213>  Homo Sapiens

<400>  3023

Met Gln Arg Trp Thr Leu Trp Ala Ala Ala Phe Leu Thr Leu His Ser 
1               5                   10                  15      


Ala Gln Ala Phe Pro Gln Thr Asp Ile Ser Ile Ser Pro Ala Leu Pro 
            20                  25                  30          


Glu Leu Pro Leu Pro Ser Leu Cys Pro Leu Phe Trp Met Glu Phe Lys 
        35                  40                  45              


Gly His Cys Tyr Arg Phe Phe Pro Leu Asn Lys Thr Trp Ala Glu Ala 
    50                  55                  60                  


Asp Leu Tyr Cys Ser Glu Phe Ser Val Gly Arg Lys Ser Ala Lys Leu 
65                  70                  75                  80  


Ala Ser Ile His Ser Leu 
                85      


<210>  3024
<211>  186
<212>  PRT
<213>  Homo Sapiens

<400>  3024

Met Gln Arg Trp Thr Leu Trp Ala Ala Ala Phe Leu Thr Leu His Ser 
1               5                   10                  15      


Ala Gln Ala Phe Pro Gln Thr Asp Ile Ser Ile Ser Pro Ala Leu Pro 
            20                  25                  30          


Glu Leu Pro Leu Pro Ser Leu Cys Pro Leu Phe Trp Met Glu Phe Lys 
        35                  40                  45              


Gly His Cys Tyr Arg Phe Phe Pro Leu Asn Lys Thr Trp Ala Glu Ala 
    50                  55                  60                  


Asp Leu Tyr Cys Ser Glu Phe Ser Val Gly Arg Lys Ser Ala Lys Leu 
65                  70                  75                  80  


Ala Ser Ile His Ser Trp Glu Glu Asn Val Phe Val Tyr Asp Leu Val 
                85                  90                  95      


Asn Ser Cys Val Pro Gly Ile Pro Ala Asp Val Trp Thr Gly Leu His 
            100                 105                 110         


Asp His Arg Gln Glu Gly Gln Phe Glu Trp Thr Asp Gly Ser Ser Tyr 
        115                 120                 125             


Asp Tyr Ser Tyr Trp Asp Gly Ser Gln Pro Asp Asp Gly Val His Ala 
    130                 135                 140                 


Asp Pro Glu Glu Glu Asp Cys Val Gln Ile Trp Tyr Arg Pro Thr Ser 
145                 150                 155                 160 


Ala Leu Arg Ser Trp Asn Asp Asn Thr Cys Ser Arg Lys Phe Pro Phe 
                165                 170                 175     


Val Cys Lys Ile Pro Ser Leu Thr Ile His 
            180                 185     


<210>  3025
<211>  136
<212>  PRT
<213>  Homo Sapiens

<400>  3025

Met Gln Arg Trp Thr Leu Trp Ala Ala Ala Phe Leu Thr Leu His Ser 
1               5                   10                  15      


Ala Gln Ala Phe Pro Gln Thr Asp Ile Ser Ile Ser Pro Ala Leu Pro 
            20                  25                  30          


Glu Leu Pro Leu Pro Ser Leu Cys Pro Leu Phe Trp Met Glu Phe Lys 
        35                  40                  45              


Gly His Cys Tyr Arg Phe Phe Pro Leu Asn Lys Thr Trp Ala Glu Ala 
    50                  55                  60                  


Asp Leu Tyr Cys Ser Glu Phe Ser Val Gly Arg Lys Ser Ala Lys Leu 
65                  70                  75                  80  


Ala Ser Ile His Ser Trp Glu Glu Asn Val Phe Val Tyr Asp Leu Val 
                85                  90                  95      


Asn Ser Cys Val Pro Gly Ile Pro Ala Asp Val Trp Thr Gly Leu His 
            100                 105                 110         


Asp His Arg Gln Val Arg Lys Gln Trp Pro Leu Gly Pro Leu Gly Ser 
        115                 120                 125             


Ser Ser Gln Asp Ser Ile Leu Ile 
    130                 135     


<210>  3026
<211>  65
<212>  PRT
<213>  Homo Sapiens

<400>  3026

Met Gln Arg Trp Thr Leu Trp Ala Ala Ala Phe Leu Thr Leu His Ser 
1               5                   10                  15      


Ala Gln Ala Phe Pro Gln Thr Asp Ile Ser Ile Ser Pro Val Cys Phe 
            20                  25                  30          


Leu Ser Ala Pro Ser Pro Ala Arg Ala Ala Pro Ala Phe Pro Val Pro 
        35                  40                  45              


Pro Val Leu Asp Gly Val Gln Arg Pro Leu Leu Ser Ile Leu Pro Ser 
    50                  55                  60                  


Gln 
65  


<210>  3027
<211>  80
<212>  PRT
<213>  Homo Sapiens

<400>  3027

Met Ile Leu Lys Leu Ile Leu Ser Leu Lys Asn Phe Leu Arg Arg Tyr 
1               5                   10                  15      


Lys Cys Ser Ser Asp His Trp Ile Gly Leu Lys Met Ala Lys Asn Arg 
            20                  25                  30          


Thr Gly Gln Trp Val Asp Gly Ala Thr Phe Thr Lys Ser Phe Gly Met 
        35                  40                  45              


Arg Gly Ser Glu Gly Cys Ala Tyr Leu Ser Asp Asp Gly Ala Ala Thr 
    50                  55                  60                  


Ala Arg Cys Tyr Thr Glu Arg Lys Trp Ile Cys Arg Lys Arg Ile His 
65                  70                  75                  80  


<210>  3028
<211>  149
<212>  PRT
<213>  Homo Sapiens

<400>  3028

Met Met Thr Lys His Lys Lys Cys Phe Ile Ile Val Gly Val Leu Ile 
1               5                   10                  15      


Thr Thr Asn Ile Ile Thr Leu Ile Val Lys Leu Thr Arg Asp Ser Gln 
            20                  25                  30          


Ser Leu Cys Pro Tyr Asp Trp Ile Gly Phe Gln Asn Lys Cys Tyr Tyr 
        35                  40                  45              


Phe Ser Lys Glu Glu Gly Asp Trp Asn Ser Ser Lys Tyr Asn Cys Ser 
    50                  55                  60                  


Thr Gln His Ala Asp Leu Thr Ile Ile Asp Asn Ile Glu Glu Met Asn 
65                  70                  75                  80  


Phe Leu Arg Arg Tyr Lys Cys Ser Ser Asp His Trp Ile Gly Leu Lys 
                85                  90                  95      


Met Ala Lys Asn Arg Thr Gly Gln Trp Val Asp Gly Ala Thr Phe Thr 
            100                 105                 110         


Lys Ser Phe Gly Met Arg Gly Ser Glu Gly Cys Ala Tyr Leu Ser Asp 
        115                 120                 125             


Asp Gly Ala Ala Thr Ala Arg Cys Tyr Thr Glu Arg Lys Trp Ile Cys 
    130                 135                 140                 


Arg Lys Arg Ile His 
145                 


<210>  3029
<211>  206
<212>  PRT
<213>  Homo Sapiens

<400>  3029

Met Ala Gln Gln Ala Cys Pro Arg Ala Met Ala Lys Asn Gly Leu Val 
1               5                   10                  15      


Ile Cys Ile Leu Val Ile Thr Leu Leu Leu Asp Gln Thr Thr Ser His 
            20                  25                  30          


Thr Ser Arg Leu Lys Ala Arg Lys His Ser Lys Arg Arg Val Arg Asp 
        35                  40                  45              


Lys Asp Gly Asp Leu Lys Thr Gln Ile Glu Lys Leu Trp Thr Glu Val 
    50                  55                  60                  


Asn Ala Leu Lys Glu Ile Gln Ala Leu Gln Thr Val Cys Leu Arg Gly 
65                  70                  75                  80  


Thr Lys Val His Lys Lys Cys Tyr Leu Ala Ser Glu Gly Leu Lys His 
                85                  90                  95      


Phe His Glu Ala Asn Glu Asp Cys Ile Ser Lys Gly Gly Ile Leu Val 
            100                 105                 110         


Ile Pro Arg Asn Ser Asp Glu Ile Asn Ala Leu Gln Asp Tyr Gly Lys 
        115                 120                 125             


Arg Ser Leu Pro Gly Val Asn Asp Phe Trp Leu Gly Ile Asn Asp Met 
    130                 135                 140                 


Val Thr Glu Gly Lys Phe Val Asp Val Asn Gly Ile Ala Ile Ser Phe 
145                 150                 155                 160 


Leu Asn Trp Asp Arg Ala Gln Pro Asn Gly Gly Lys Arg Glu Asn Cys 
                165                 170                 175     


Val Leu Phe Ser Gln Ser Ala Gln Gly Lys Trp Ser Asp Glu Ala Cys 
            180                 185                 190         


Arg Ser Ser Lys Arg Tyr Ile Cys Glu Phe Thr Ile Pro Gln 
        195                 200                 205     


<210>  3030
<211>  50
<212>  PRT
<213>  Homo Sapiens

<400>  3030

Met Ala Gln Gln Ala Cys Pro Arg Ala Met Ala Lys Asn Gly Leu Val 
1               5                   10                  15      


Ile Cys Ile Leu Val Ile Thr Leu Leu Leu Asp Gln Thr Thr Ser His 
            20                  25                  30          


Thr Ser Arg Leu Lys Ala Arg Lys His Ser Lys Arg Arg Val Arg Gly 
        35                  40                  45              


Ile Cys 
    50  


<210>  3031
<211>  202
<212>  PRT
<213>  Homo Sapiens

<400>  3031

Met Glu Leu Trp Gly Ala Tyr Leu Leu Leu Cys Leu Phe Ser Leu Leu 
1               5                   10                  15      


Thr Gln Val Thr Thr Glu Pro Pro Thr Gln Lys Pro Lys Lys Ile Val 
            20                  25                  30          


Asn Ala Lys Lys Asp Val Val Asn Thr Lys Met Phe Glu Glu Leu Lys 
        35                  40                  45              


Ser Arg Leu Asp Thr Leu Ala Gln Glu Val Ala Leu Leu Lys Glu Gln 
    50                  55                  60                  


Gln Ala Leu Gln Thr Val Cys Leu Lys Gly Thr Lys Val His Met Lys 
65                  70                  75                  80  


Cys Phe Leu Ala Phe Thr Gln Thr Lys Thr Phe His Glu Ala Ser Glu 
                85                  90                  95      


Asp Cys Ile Ser Arg Gly Gly Thr Leu Gly Thr Pro Gln Thr Gly Ser 
            100                 105                 110         


Glu Asn Asp Ala Leu Tyr Glu Tyr Leu Arg Gln Ser Val Gly Asn Glu 
        115                 120                 125             


Ala Glu Ile Trp Leu Gly Leu Asn Asp Met Ala Ala Glu Gly Thr Trp 
    130                 135                 140                 


Val Asp Met Thr Gly Ala Arg Ile Ala Tyr Lys Asn Trp Glu Thr Glu 
145                 150                 155                 160 


Ile Thr Ala Gln Pro Asp Gly Gly Lys Thr Glu Asn Cys Ala Val Leu 
                165                 170                 175     


Ser Gly Ala Ala Asn Gly Lys Trp Phe Asp Lys Arg Cys Arg Asp Gln 
            180                 185                 190         


Leu Pro Tyr Ile Cys Gln Phe Gly Ile Val 
        195                 200         


<210>  3032
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  3032

Met Phe Glu Glu Leu Lys Ser Arg Leu Asp Thr Leu Ala Gln Glu Val 
1               5                   10                  15      


Ala Leu Leu Lys Glu Gln Gln Ala Leu Gln Thr Val Cys Leu Lys Gly 
            20                  25                  30          


Thr Lys Val His Met Lys Cys Phe Leu Ala Phe Thr Gln Thr Lys Thr 
        35                  40                  45              


Phe His Glu Ala Ser Glu Asp Cys Ile Ser Arg Gly Gly Thr Leu Gly 
    50                  55                  60                  


Thr Pro Gln Thr Gly Ser Glu Asn Asp Ala Leu Tyr Glu Tyr Leu Arg 
65                  70                  75                  80  


Gln Ser Val Gly Asn Glu Ala Glu Ile Trp Leu Gly Leu Asn Asp Met 
                85                  90                  95      


Ala Ala Glu Gly Thr Trp Val Asp Met Thr Gly Ala Arg Ile Ala Tyr 
            100                 105                 110         


Lys Asn Trp Glu Thr Glu Ile Thr Ala Gln Pro Asp Gly Gly Lys Thr 
        115                 120                 125             


Glu Asn Cys Ala Val Leu Ser Gly Ala Ala Asn Gly Lys Trp Phe Asp 
    130                 135                 140                 


Lys Arg Cys Arg Asp Gln Leu Pro Tyr Ile Cys Gln Phe Gly Ile Val 
145                 150                 155                 160 


<210>  3033
<211>  179
<212>  PRT
<213>  Homo Sapiens

<400>  3033

Met His Phe Gln Ala Phe Trp Leu Cys Leu Gly Leu Leu Phe Ile Ser 
1               5                   10                  15      


Ile Asn Ala Glu Phe Met Asp Asp Asp Val Glu Thr Glu Asp Phe Glu 
            20                  25                  30          


Glu Asn Ser Glu Glu Ile Asp Val Asn Glu Ser Glu Leu Ser Ser Glu 
        35                  40                  45              


Ile Lys Tyr Lys Thr Pro Gln Pro Ile Gly Glu Val Tyr Phe Ala Glu 
    50                  55                  60                  


Thr Phe Asp Ser Gly Arg Leu Ala Gly Trp Val Leu Ser Lys Ala Lys 
65                  70                  75                  80  


Lys Asp Asp Met Asp Glu Glu Ile Ser Ile Tyr Asp Gly Arg Trp Glu 
                85                  90                  95      


Ile Glu Glu Leu Lys Glu Asn Gln Val Pro Gly Asp Arg Gly Leu Val 
            100                 105                 110         


Leu Lys Ser Arg Ala Lys His His Ala Ile Ser Ala Val Leu Ala Lys 
        115                 120                 125             


Pro Phe Ile Phe Ala Asp Lys Pro Leu Ile Val Gln Tyr Glu Val Asn 
    130                 135                 140                 


Phe Gln Asp Gly Ile Asp Cys Gly Gly Ala Tyr Ile Lys Leu Leu Ala 
145                 150                 155                 160 


Asp Thr Asp Asp Leu Ile Leu Glu Asn Phe Tyr Asp Lys Thr Ser Tyr 
                165                 170                 175     


Ile Ile Met 
            


<210>  3034
<211>  610
<212>  PRT
<213>  Homo Sapiens

<400>  3034

Met His Phe Gln Ala Phe Trp Leu Cys Leu Gly Leu Leu Phe Ile Ser 
1               5                   10                  15      


Ile Asn Ala Glu Phe Met Asp Asp Asp Val Glu Thr Glu Asp Phe Glu 
            20                  25                  30          


Glu Asn Ser Glu Glu Ile Asp Val Asn Glu Ser Glu Leu Ser Ser Glu 
        35                  40                  45              


Ile Lys Tyr Lys Thr Pro Gln Pro Ile Gly Glu Val Tyr Phe Ala Glu 
    50                  55                  60                  


Thr Phe Asp Ser Gly Arg Leu Ala Gly Trp Val Leu Ser Lys Ala Lys 
65                  70                  75                  80  


Lys Asp Asp Met Asp Glu Glu Ile Ser Ile Tyr Asp Gly Arg Trp Glu 
                85                  90                  95      


Ile Glu Glu Leu Lys Glu Asn Gln Val Pro Gly Asp Arg Gly Leu Val 
            100                 105                 110         


Leu Lys Ser Arg Ala Lys His His Ala Ile Ser Ala Val Leu Ala Lys 
        115                 120                 125             


Pro Phe Ile Phe Ala Asp Lys Pro Leu Ile Val Gln Tyr Glu Val Asn 
    130                 135                 140                 


Phe Gln Asp Gly Ile Asp Cys Gly Gly Ala Tyr Ile Lys Leu Leu Ala 
145                 150                 155                 160 


Asp Thr Asp Asp Leu Ile Leu Glu Asn Phe Tyr Asp Lys Thr Ser Tyr 
                165                 170                 175     


Ile Ile Met Phe Gly Pro Asp Lys Cys Gly Glu Asp Tyr Lys Leu His 
            180                 185                 190         


Phe Ile Phe Arg His Lys His Pro Lys Thr Gly Val Phe Glu Glu Lys 
        195                 200                 205             


His Ala Lys Pro Pro Asp Val Asp Leu Lys Lys Phe Phe Thr Asp Arg 
    210                 215                 220                 


Lys Thr His Leu Tyr Thr Leu Val Met Asn Pro Asp Asp Thr Phe Glu 
225                 230                 235                 240 


Val Leu Val Asp Gln Thr Val Val Asn Lys Gly Ser Leu Leu Glu Asp 
                245                 250                 255     


Val Val Pro Pro Ile Lys Pro Pro Lys Glu Ile Glu Asp Pro Asn Asp 
            260                 265                 270         


Lys Lys Pro Glu Glu Trp Asp Glu Arg Ala Lys Ile Pro Asp Pro Ser 
        275                 280                 285             


Ala Val Lys Pro Glu Asp Trp Asp Glu Ser Glu Pro Ala Gln Ile Glu 
    290                 295                 300                 


Asp Ser Ser Val Val Lys Pro Ala Gly Trp Leu Asp Asp Glu Pro Lys 
305                 310                 315                 320 


Phe Ile Pro Asp Pro Asn Ala Glu Lys Pro Asp Asp Trp Asn Glu Asp 
                325                 330                 335     


Thr Asp Gly Glu Trp Glu Ala Pro Gln Ile Leu Asn Pro Ala Cys Arg 
            340                 345                 350         


Ile Gly Cys Gly Glu Trp Lys Pro Pro Met Ile Asp Asn Pro Lys Tyr 
        355                 360                 365             


Lys Gly Val Trp Arg Pro Pro Leu Val Asp Asn Pro Asn Tyr Gln Gly 
    370                 375                 380                 


Ile Trp Ser Pro Arg Lys Ile Pro Asn Pro Asp Tyr Phe Glu Asp Asp 
385                 390                 395                 400 


His Pro Phe Leu Leu Thr Ser Phe Ser Ala Leu Gly Leu Glu Leu Trp 
                405                 410                 415     


Ser Met Thr Ser Asp Ile Tyr Phe Asp Asn Phe Ile Ile Cys Ser Glu 
            420                 425                 430         


Lys Glu Val Ala Asp His Trp Ala Ala Asp Gly Trp Arg Trp Lys Ile 
        435                 440                 445             


Met Ile Ala Asn Ala Asn Lys Pro Gly Val Leu Lys Gln Leu Met Ala 
    450                 455                 460                 


Ala Ala Glu Gly His Pro Trp Leu Trp Leu Ile Tyr Leu Val Thr Ala 
465                 470                 475                 480 


Gly Val Pro Ile Ala Leu Ile Thr Ser Phe Cys Trp Pro Arg Lys Val 
                485                 490                 495     


Lys Lys Lys His Lys Asp Thr Glu Tyr Lys Lys Thr Asp Ile Cys Ile 
            500                 505                 510         


Pro Gln Thr Lys Gly Val Leu Glu Gln Glu Glu Lys Glu Glu Lys Ala 
        515                 520                 525             


Ala Leu Glu Lys Pro Met Asp Leu Glu Glu Glu Lys Lys Gln Asn Asp 
    530                 535                 540                 


Gly Glu Met Leu Glu Lys Glu Glu Glu Ser Glu Pro Glu Glu Lys Ser 
545                 550                 555                 560 


Glu Glu Glu Ile Glu Ile Ile Glu Gly Gln Glu Glu Ser Asn Gln Ser 
                565                 570                 575     


Asn Lys Ser Gly Ser Glu Asp Glu Met Lys Glu Ala Asp Glu Ser Thr 
            580                 585                 590         


Gly Ser Gly Asp Gly Pro Ile Lys Ser Val Arg Lys Arg Arg Val Arg 
        595                 600                 605             


Lys Asp 
    610 


<210>  3035
<211>  610
<212>  PRT
<213>  Homo Sapiens

<400>  3035

Met His Phe Gln Ala Phe Trp Leu Cys Leu Gly Leu Leu Phe Ile Ser 
1               5                   10                  15      


Ile Asn Ala Glu Phe Met Asp Asp Asp Val Glu Thr Glu Asp Phe Glu 
            20                  25                  30          


Glu Asn Ser Glu Glu Ile Asp Val Asn Glu Ser Glu Leu Ser Ser Glu 
        35                  40                  45              


Ile Lys Tyr Lys Thr Pro Gln Pro Ile Gly Glu Val Tyr Phe Ala Glu 
    50                  55                  60                  


Thr Phe Asp Ser Gly Arg Leu Ala Gly Trp Val Leu Ser Lys Ala Lys 
65                  70                  75                  80  


Lys Asp Asp Met Asp Glu Glu Ile Ser Ile Tyr Asp Gly Arg Trp Glu 
                85                  90                  95      


Ile Glu Glu Leu Lys Glu Asn Gln Val Pro Gly Asp Arg Gly Leu Val 
            100                 105                 110         


Leu Lys Ser Arg Ala Lys His His Ala Ile Ser Ala Val Leu Ala Lys 
        115                 120                 125             


Pro Phe Ile Phe Ala Asp Lys Pro Leu Ile Val Gln Tyr Glu Val Asn 
    130                 135                 140                 


Phe Gln Asp Gly Ile Asp Cys Gly Gly Ala Tyr Ile Lys Leu Leu Ala 
145                 150                 155                 160 


Asp Thr Asp Asp Leu Ile Leu Glu Asn Phe Tyr Asp Lys Thr Ser Tyr 
                165                 170                 175     


Ile Ile Met Phe Gly Pro Asp Lys Cys Gly Glu Asp Tyr Lys Leu His 
            180                 185                 190         


Phe Ile Phe Arg His Lys His Pro Lys Thr Gly Val Phe Glu Glu Lys 
        195                 200                 205             


His Ala Lys Pro Pro Asp Val Asp Leu Lys Lys Phe Phe Thr Asp Arg 
    210                 215                 220                 


Lys Thr His Leu Tyr Thr Leu Val Met Asn Pro Asp Asp Thr Phe Glu 
225                 230                 235                 240 


Val Leu Val Asp Gln Thr Val Val Asn Lys Gly Ser Leu Leu Glu Asp 
                245                 250                 255     


Val Val Pro Pro Ile Lys Pro Pro Lys Glu Ile Glu Asp Pro Asn Asp 
            260                 265                 270         


Lys Lys Pro Glu Glu Trp Asp Glu Arg Ala Lys Ile Pro Asp Pro Ser 
        275                 280                 285             


Ala Val Lys Pro Glu Asp Trp Asp Glu Ser Glu Pro Ala Gln Ile Glu 
    290                 295                 300                 


Asp Ser Ser Val Val Lys Pro Ala Gly Trp Leu Asp Asp Glu Pro Lys 
305                 310                 315                 320 


Phe Ile Pro Asp Pro Asn Ala Glu Lys Pro Asp Asp Trp Asn Glu Asp 
                325                 330                 335     


Thr Asp Gly Glu Trp Glu Ala Pro Gln Ile Leu Asn Pro Ala Cys Arg 
            340                 345                 350         


Ile Gly Cys Gly Glu Trp Lys Pro Pro Met Ile Asp Asn Pro Lys Tyr 
        355                 360                 365             


Lys Gly Val Trp Arg Pro Pro Leu Val Asp Asn Pro Asn Tyr Gln Gly 
    370                 375                 380                 


Ile Trp Ser Pro Arg Lys Ile Pro Asn Pro Asp Tyr Phe Glu Asp Asp 
385                 390                 395                 400 


His Pro Phe Leu Leu Thr Ser Phe Ser Ala Leu Gly Leu Glu Leu Trp 
                405                 410                 415     


Ser Met Thr Ser Asp Ile Tyr Phe Asp Asn Phe Ile Ile Cys Ser Glu 
            420                 425                 430         


Lys Glu Val Ala Asp His Trp Ala Ala Asp Gly Trp Arg Trp Lys Ile 
        435                 440                 445             


Met Ile Ala Asn Ala Asn Lys Pro Gly Val Leu Lys Gln Leu Met Ala 
    450                 455                 460                 


Ala Ala Glu Gly His Pro Trp Leu Trp Leu Ile Tyr Leu Val Thr Ala 
465                 470                 475                 480 


Gly Val Pro Ile Ala Leu Ile Thr Ser Phe Cys Trp Pro Arg Lys Val 
                485                 490                 495     


Lys Lys Lys His Lys Asp Thr Glu Tyr Lys Lys Thr Asp Ile Cys Ile 
            500                 505                 510         


Pro Gln Thr Lys Gly Val Leu Glu Gln Glu Glu Lys Glu Glu Lys Ala 
        515                 520                 525             


Ala Leu Glu Lys Pro Met Asp Leu Glu Glu Glu Lys Lys Gln Asn Asp 
    530                 535                 540                 


Gly Glu Met Leu Glu Lys Glu Glu Glu Ser Glu Pro Glu Glu Lys Ser 
545                 550                 555                 560 


Glu Glu Glu Ile Glu Ile Ile Glu Gly Gln Glu Glu Ser Asn Gln Ser 
                565                 570                 575     


Asn Lys Ser Gly Ser Glu Asp Glu Met Lys Glu Ala Asp Glu Ser Thr 
            580                 585                 590         


Gly Ser Gly Asp Gly Pro Ile Lys Ser Val Arg Lys Arg Arg Val Arg 
        595                 600                 605             


Lys Asp 
    610 


<210>  3036
<211>  277
<212>  PRT
<213>  Homo Sapiens

<400>  3036

Gly Cys Ser Leu Met Ala Gln Glu Val Asp Thr Ala Gln Gly Ala Glu 
1               5                   10                  15      


Met Arg Arg Gly Ala Gly Ala Ala Arg Gly Arg Ala Ser Trp Cys Trp 
            20                  25                  30          


Ala Leu Ala Leu Leu Trp Leu Ala Val Val Pro Gly Trp Ser Arg Val 
        35                  40                  45              


Ser Gly Ile Pro Ser Arg Arg His Trp Pro Val Pro Tyr Lys Arg Phe 
    50                  55                  60                  


Asp Phe Arg Pro Lys Pro Asp Pro Tyr Cys Gln Ala Lys Tyr Thr Phe 
65                  70                  75                  80  


Cys Pro Thr Gly Ser Pro Ile Pro Val Met Glu Gly Asp Asp Asp Ile 
                85                  90                  95      


Glu Val Phe Arg Leu Gln Ala Pro Val Trp Glu Phe Lys Tyr Gly Asp 
            100                 105                 110         


Leu Leu Gly His Leu Lys Ile Met His Asp Ala Ile Gly Phe Arg Ser 
        115                 120                 125             


Thr Leu Thr Gly Lys Asn Tyr Thr Met Glu Trp Tyr Glu Leu Phe Gln 
    130                 135                 140                 


Leu Gly Asn Cys Thr Phe Pro His Leu Arg Pro Glu Met Asp Ala Pro 
145                 150                 155                 160 


Phe Trp Cys Asn Gln Gly Ala Ala Cys Phe Phe Glu Gly Ile Asp Asp 
                165                 170                 175     


Val His Trp Lys Glu Asn Gly Thr Leu Val Gln Val Ala Thr Ile Ser 
            180                 185                 190         


Gly Phe His His Val Gly Gln Asp Ser Ile Glu Leu Arg Thr Ser Ser 
        195                 200                 205             


Asp Pro Pro Ile Leu Ala Ser Gln Ser Ala Gly Ile Thr Asp Val Ser 
    210                 215                 220                 


His Cys Thr Arg Pro Thr Ile Arg Ile Leu Pro Gln Arg Gly Thr Leu 
225                 230                 235                 240 


Tyr Tyr Leu Ser Leu Ala Leu Leu Pro Gly Trp Ser Thr Val Val Arg 
                245                 250                 255     


Pro Arg Leu Thr Ala Thr Ser Ala Ser Arg Ile Gln Thr Ile Phe Leu 
            260                 265                 270         


Pro Gln Pro Pro Lys 
        275         


<210>  3037
<211>  204
<212>  PRT
<213>  Homo Sapiens

<400>  3037

Gly Ser Thr Gly Cys Ser Leu Met Ala Gln Glu Val Asp Thr Ala Gln 
1               5                   10                  15      


Gly Ala Glu Met Arg Arg Gly Ala Gly Ala Ala Arg Gly Arg Ala Ser 
            20                  25                  30          


Trp Cys Trp Ala Leu Ala Leu Leu Trp Leu Ala Val Val Pro Gly Trp 
        35                  40                  45              


Ser Arg Val Ser Gly Ile Pro Ser Arg Arg His Trp Pro Val Pro Tyr 
    50                  55                  60                  


Lys Arg Phe Asp Phe Arg Pro Lys Pro Asp Pro Tyr Cys Gln Ala Lys 
65                  70                  75                  80  


Tyr Thr Phe Cys Pro Thr Gly Ser Pro Ile Pro Val Met Glu Gly Asp 
                85                  90                  95      


Asp Asp Ile Glu Val Phe Arg Leu Gln Ala Pro Val Trp Glu Phe Lys 
            100                 105                 110         


Tyr Gly Asp Leu Leu Gly His Leu Lys Ile Met His Asp Ala Ile Gly 
        115                 120                 125             


Phe Arg Ser Thr Leu Thr Gly Lys Asn Tyr Thr Met Glu Trp Tyr Glu 
    130                 135                 140                 


Leu Phe Gln Leu Gly Asn Cys Thr Phe Pro His Leu Arg Pro Glu Met 
145                 150                 155                 160 


Asp Ala Pro Phe Trp Cys Asn Gln Gly Ala Ala Cys Phe Phe Glu Gly 
                165                 170                 175     


Ile Asp Asp Val His Trp Lys Glu Asn Gly Thr Leu Val Gln Val Ala 
            180                 185                 190         


Thr Ile Ser Asp Gly Glu Thr Glu Ala Gln Arg Gly 
        195                 200                 


<210>  3038
<211>  271
<212>  PRT
<213>  Homo Sapiens

<400>  3038

Leu Met Ala Gln Glu Val Asp Thr Ala Gln Gly Ala Glu Met Arg Arg 
1               5                   10                  15      


Gly Ala Gly Ala Ala Arg Gly Arg Ala Ser Trp Cys Trp Ala Leu Ala 
            20                  25                  30          


Leu Leu Trp Leu Ala Val Val Pro Gly Trp Ser Arg Val Ser Gly Ile 
        35                  40                  45              


Pro Ser Arg Arg His Trp Pro Val Pro Tyr Lys Arg Phe Asp Phe Arg 
    50                  55                  60                  


Pro Lys Pro Asp Pro Tyr Cys Gln Ala Lys Tyr Thr Phe Cys Pro Thr 
65                  70                  75                  80  


Gly Ser Pro Ile Pro Val Met Glu Gly Asp Asp Asp Ile Glu Val Phe 
                85                  90                  95      


Arg Leu Gln Ala Pro Val Trp Glu Phe Lys Tyr Gly Asp Leu Leu Gly 
            100                 105                 110         


His Leu Lys Ile Met His Asp Ala Ile Gly Phe Arg Ser Thr Leu Thr 
        115                 120                 125             


Gly Lys Asn Tyr Thr Met Glu Trp Tyr Glu Leu Phe Gln Leu Gly Asn 
    130                 135                 140                 


Cys Thr Phe Pro His Leu Arg Pro Glu Met Asp Ala Pro Phe Trp Cys 
145                 150                 155                 160 


Asn Gln Gly Ala Ala Cys Phe Phe Glu Gly Ile Asp Asp Val His Trp 
                165                 170                 175     


Lys Glu Asn Gly Thr Leu Val Gln Val Ala Thr Ile Ser Gly Phe His 
            180                 185                 190         


His Val Gly Gln Asp Ser Ile Glu Leu Arg Thr Ser Ser Asp Pro Pro 
        195                 200                 205             


Ile Leu Ala Ser Gln Ser Ala Gly Ile Thr Asp Val Ser His Cys Thr 
    210                 215                 220                 


Arg Pro Thr Ile Arg Ile Leu Pro Gln Arg Gly Thr Leu Tyr Tyr Leu 
225                 230                 235                 240 


Leu Trp Thr Lys Thr Phe Leu Leu Cys Ser Leu Gln Phe Ser Trp Asp 
                245                 250                 255     


Phe Gln Asn Ile Ala Thr Pro Tyr Phe Asn Leu Leu Pro Lys Pro 
            260                 265                 270     


<210>  3039
<211>  358
<212>  PRT
<213>  Homo Sapiens

<400>  3039

Met Ala Gln Glu Val Asp Thr Ala Gln Gly Ala Glu Met Arg Arg Gly 
1               5                   10                  15      


Ala Gly Ala Ala Arg Gly Arg Ala Ser Trp Cys Trp Ala Leu Ala Leu 
            20                  25                  30          


Leu Trp Leu Ala Val Val Pro Gly Trp Ser Arg Val Ser Gly Ile Pro 
        35                  40                  45              


Ser Arg Arg His Trp Pro Val Pro Tyr Lys Arg Phe Asp Phe Arg Pro 
    50                  55                  60                  


Lys Pro Asp Pro Tyr Cys Gln Ala Lys Tyr Thr Phe Cys Pro Thr Gly 
65                  70                  75                  80  


Ser Pro Ile Pro Val Met Glu Gly Asp Asp Asp Ile Glu Val Phe Arg 
                85                  90                  95      


Leu Gln Ala Pro Val Trp Glu Phe Lys Tyr Gly Asp Leu Leu Gly His 
            100                 105                 110         


Leu Lys Ile Met His Asp Ala Ile Gly Phe Arg Ser Thr Leu Thr Gly 
        115                 120                 125             


Lys Asn Tyr Thr Met Glu Trp Tyr Glu Leu Phe Gln Leu Gly Asn Cys 
    130                 135                 140                 


Thr Phe Pro His Leu Arg Pro Glu Met Asp Ala Pro Phe Trp Cys Asn 
145                 150                 155                 160 


Gln Gly Ala Ala Cys Phe Phe Glu Gly Ile Asp Asp Val His Trp Lys 
                165                 170                 175     


Glu Asn Gly Thr Leu Val Gln Val Ala Thr Ile Ser Gly Asn Met Phe 
            180                 185                 190         


Asn Gln Met Ala Lys Trp Val Lys Gln Asp Asn Glu Thr Gly Ile Tyr 
        195                 200                 205             


Tyr Glu Thr Trp Asn Val Lys Ala Ser Pro Glu Lys Gly Ala Glu Thr 
    210                 215                 220                 


Trp Phe Asp Ser Tyr Asp Cys Ser Lys Phe Val Leu Arg Thr Phe Asn 
225                 230                 235                 240 


Lys Leu Ala Glu Phe Gly Ala Glu Phe Lys Asn Ile Glu Thr Asn Tyr 
                245                 250                 255     


Thr Arg Ile Phe Leu Tyr Ser Gly Glu Pro Thr Tyr Leu Gly Asn Glu 
            260                 265                 270         


Thr Ser Val Phe Gly Pro Thr Gly Asn Lys Thr Leu Gly Leu Ala Ile 
        275                 280                 285             


Lys Arg Phe Tyr Tyr Pro Phe Lys Pro His Leu Pro Thr Lys Glu Phe 
    290                 295                 300                 


Leu Leu Ser Leu Leu Gln Ile Phe Asp Ala Val Ile Val His Lys Gln 
305                 310                 315                 320 


Phe Tyr Leu Phe Tyr Asn Phe Glu Tyr Trp Phe Leu Pro Met Lys Phe 
                325                 330                 335     


Pro Phe Ile Lys Ile Thr Tyr Glu Glu Ile Pro Leu Pro Ile Arg Asn 
            340                 345                 350         


Lys Thr Leu Ser Gly Leu 
        355             


<210>  3040
<211>  36
<212>  PRT
<213>  Homo Sapiens

<400>  3040

Met Glu Gly Asp Asp Asp Ile Glu Val Phe Arg Leu Gln Ala Pro Val 
1               5                   10                  15      


Trp Glu Phe Lys Tyr Gly Asp Leu Leu Gly His Leu Leu Leu Tyr Leu 
            20                  25                  30          


Ala Pro Gly Arg 
        35      


<210>  3041
<211>  407
<212>  PRT
<213>  Homo Sapiens

<400>  3041

Met Arg Arg Asn Leu Arg Leu Gly Pro Ser Ser Gly Ala Asp Ala Gln 
1               5                   10                  15      


Gly Gln Gly Ala Pro Arg Pro Gly Leu Ala Ala Pro Arg Met Leu Leu 
            20                  25                  30          


Pro Pro Ala Ser Gln Ala Ser Arg Gly Ser Gly Ser Thr Gly Cys Ser 
        35                  40                  45              


Leu Met Ala Gln Glu Val Asp Thr Ala Gln Gly Ala Glu Met Arg Arg 
    50                  55                  60                  


Gly Ala Gly Ala Ala Arg Gly Arg Ala Ser Trp Cys Trp Ala Leu Ala 
65                  70                  75                  80  


Leu Leu Trp Leu Ala Val Val Pro Gly Trp Ser Arg Val Ser Gly Ile 
                85                  90                  95      


Pro Ser Arg Arg His Trp Pro Val Pro Tyr Lys Arg Phe Asp Phe Arg 
            100                 105                 110         


Pro Lys Pro Asp Pro Tyr Cys Gln Ala Lys Tyr Thr Phe Cys Pro Thr 
        115                 120                 125             


Gly Ser Pro Ile Pro Val Met Glu Gly Asp Asp Asp Ile Glu Val Phe 
    130                 135                 140                 


Arg Leu Gln Ala Pro Val Trp Glu Phe Lys Tyr Gly Asp Leu Leu Gly 
145                 150                 155                 160 


His Leu Lys Ile Met His Asp Ala Ile Gly Phe Arg Ser Thr Leu Thr 
                165                 170                 175     


Gly Lys Asn Tyr Thr Met Glu Trp Tyr Glu Leu Phe Gln Leu Gly Asn 
            180                 185                 190         


Cys Thr Phe Pro His Leu Arg Pro Glu Met Asp Ala Pro Phe Trp Cys 
        195                 200                 205             


Asn Gln Gly Ala Ala Cys Phe Phe Glu Gly Ile Asp Asp Val His Trp 
    210                 215                 220                 


Lys Glu Asn Gly Thr Leu Val Gln Val Ala Thr Ile Ser Gly Asn Met 
225                 230                 235                 240 


Phe Asn Gln Met Ala Lys Trp Val Lys Gln Asp Asn Glu Thr Gly Ile 
                245                 250                 255     


Tyr Tyr Glu Thr Trp Asn Val Lys Ala Ser Pro Glu Lys Gly Ala Glu 
            260                 265                 270         


Thr Trp Phe Asp Ser Tyr Asp Cys Ser Lys Phe Val Leu Arg Thr Phe 
        275                 280                 285             


Asn Lys Leu Ala Glu Phe Gly Ala Glu Phe Lys Asn Ile Glu Thr Asn 
    290                 295                 300                 


Tyr Thr Arg Ile Phe Leu Tyr Ser Gly Glu Pro Thr Tyr Leu Gly Asn 
305                 310                 315                 320 


Glu Thr Ser Val Phe Gly Pro Thr Gly Asn Lys Thr Leu Gly Leu Ala 
                325                 330                 335     


Ile Lys Arg Phe Tyr Tyr Pro Phe Lys Pro His Leu Pro Thr Lys Glu 
            340                 345                 350         


Phe Leu Leu Ser Leu Leu Gln Ile Phe Asp Ala Val Ile Val His Lys 
        355                 360                 365             


Gln Phe Tyr Leu Phe Tyr Asn Phe Glu Tyr Trp Phe Leu Pro Met Lys 
    370                 375                 380                 


Phe Pro Phe Ile Lys Ile Thr Tyr Glu Glu Ile Pro Leu Pro Ile Arg 
385                 390                 395                 400 


Asn Lys Thr Leu Ser Gly Leu 
                405         


<210>  3042
<211>  125
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3042

Xaa Gly Arg Ala Ser Trp Cys Trp Ala Leu Ala Leu Leu Trp Leu Ala 
1               5                   10                  15      


Val Val Pro Gly Trp Ser Arg Val Ser Gly Ile Pro Ser Arg Arg His 
            20                  25                  30          


Trp Pro Val Pro Tyr Lys Arg Phe Asp Phe Arg Pro Lys Pro Asp Pro 
        35                  40                  45              


Tyr Cys Gln Ala Lys Tyr Thr Phe Cys Pro Thr Gly Ser Pro Ile Pro 
    50                  55                  60                  


Val Met Glu Gly Asp Asp Asp Ile Glu Val Phe Arg Leu Gln Ala Pro 
65                  70                  75                  80  


Val Trp Glu Phe Lys Tyr Gly Asp Leu Leu Gly His Leu Val Thr Trp 
                85                  90                  95      


Thr His Gly Cys Val Thr Val Ala Phe Ile His Val Leu Ser Leu His 
            100                 105                 110         


Arg Lys Leu Cys Met Met Pro Leu Asp Ser Glu Val His 
        115                 120                 125 


<210>  3043
<211>  304
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3043

Xaa Gly Tyr Lys Arg Phe Asp Phe Arg Pro Lys Pro Asp Pro Tyr Cys 
1               5                   10                  15      


Gln Ala Lys Tyr Thr Phe Cys Pro Thr Gly Ser Pro Ile Pro Val Met 
            20                  25                  30          


Glu Gly Asp Asp Asp Ile Glu Val Phe Arg Leu Gln Ala Pro Val Trp 
        35                  40                  45              


Glu Phe Lys Tyr Gly Asp Leu Leu Gly His Leu Lys Ile Met His Asp 
    50                  55                  60                  


Ala Ile Gly Phe Arg Ser Thr Leu Thr Gly Lys Asn Tyr Thr Met Glu 
65                  70                  75                  80  


Trp Tyr Glu Leu Phe Gln Leu Gly Asn Cys Thr Phe Pro His Leu Arg 
                85                  90                  95      


Pro Glu Met Asp Ala Pro Phe Trp Cys Asn Gln Gly Ala Ala Cys Phe 
            100                 105                 110         


Phe Glu Gly Ile Asp Asp Val His Trp Lys Glu Asn Gly Thr Leu Val 
        115                 120                 125             


Gln Val Ala Thr Ile Ser Gly Asn Met Phe Asn Gln Met Ala Lys Trp 
    130                 135                 140                 


Val Lys Gln Asp Asn Glu Thr Gly Ile Tyr Tyr Glu Thr Trp Asn Val 
145                 150                 155                 160 


Lys Ala Ser Pro Glu Lys Gly Ala Glu Thr Trp Phe Asp Ser Tyr Asp 
                165                 170                 175     


Cys Ser Lys Phe Val Leu Arg Thr Phe Asn Lys Leu Ala Glu Phe Gly 
            180                 185                 190         


Ala Glu Phe Lys Asn Ile Glu Thr Asn Tyr Thr Arg Ile Phe Leu Tyr 
        195                 200                 205             


Ser Gly Glu Pro Thr Tyr Leu Gly Asn Glu Thr Ser Val Phe Gly Pro 
    210                 215                 220                 


Thr Gly Asn Lys Thr Leu Gly Leu Ala Ile Lys Arg Phe Tyr Tyr Pro 
225                 230                 235                 240 


Phe Lys Pro His Leu Pro Thr Lys Glu Phe Leu Leu Ser Leu Leu Gln 
                245                 250                 255     


Ile Phe Asp Ala Val Ile Val His Lys Gln Phe Tyr Leu Phe Tyr Asn 
            260                 265                 270         


Phe Glu Tyr Trp Phe Leu Pro Met Lys Phe Pro Phe Ile Lys Ile Thr 
        275                 280                 285             


Tyr Glu Glu Ile Pro Leu Pro Ile Arg Asn Lys Thr Leu Ser Gly Leu 
    290                 295                 300                 


<210>  3044
<211>  216
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3044

Xaa Leu Pro Pro Ala Ser Gln Ala Ser Arg Gly Ser Gly Ser Thr Gly 
1               5                   10                  15      


Cys Ser Leu Met Ala Gln Glu Val Asp Thr Ala Gln Gly Ala Glu Met 
            20                  25                  30          


Arg Arg Gly Ala Gly Ala Ala Arg Gly Arg Ala Ser Trp Cys Trp Ala 
        35                  40                  45              


Leu Ala Leu Leu Trp Leu Ala Val Val Pro Gly Trp Ser Arg Val Ser 
    50                  55                  60                  


Gly Ile Pro Ser Arg Arg His Trp Pro Val Pro Tyr Lys Arg Phe Asp 
65                  70                  75                  80  


Phe Arg Pro Lys Pro Asp Pro Tyr Cys Gln Ala Lys Tyr Thr Phe Cys 
                85                  90                  95      


Pro Thr Gly Ser Pro Ile Pro Val Met Glu Gly Asp Asp Asp Ile Glu 
            100                 105                 110         


Val Phe Arg Leu Gln Ala Pro Val Trp Glu Phe Lys Tyr Gly Asp Leu 
        115                 120                 125             


Leu Gly His Leu Lys Ile Met His Asp Ala Ile Gly Phe Arg Ser Thr 
    130                 135                 140                 


Leu Thr Gly Lys Asn Tyr Thr Met Glu Trp Tyr Glu Leu Phe Gln Leu 
145                 150                 155                 160 


Gly Asn Cys Thr Phe Pro His Leu Arg Pro Glu Met Asp Ala Pro Phe 
                165                 170                 175     


Trp Cys Asn Gln Gly Ala Ala Cys Phe Phe Glu Gly Ile Asp Asp Val 
            180                 185                 190         


His Trp Lys Glu Asn Gly Thr Leu Val Gln Val Ala Thr Ile Ser Asp 
        195                 200                 205             


Gly Glu Thr Glu Ala Gln Arg Gly 
    210                 215     


<210>  3045
<211>  249
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3045

Xaa Met Ala Gln Glu Val Asp Thr Ala Gln Gly Ala Glu Met Arg Arg 
1               5                   10                  15      


Gly Ala Gly Ala Ala Arg Gly Arg Ala Ser Trp Cys Trp Ala Leu Ala 
            20                  25                  30          


Leu Leu Trp Leu Ala Val Val Pro Gly Trp Ser Arg Val Ser Gly Ile 
        35                  40                  45              


Pro Ser Arg Arg His Trp Pro Val Pro Tyr Lys Arg Phe Asp Phe Arg 
    50                  55                  60                  


Pro Lys Pro Asp Pro Tyr Cys Gln Ala Lys Tyr Thr Phe Cys Pro Thr 
65                  70                  75                  80  


Gly Ser Pro Ile Pro Val Met Glu Gly Asp Asp Asp Ile Glu Val Phe 
                85                  90                  95      


Arg Leu Gln Ala Pro Val Trp Glu Phe Lys Tyr Gly Asp Leu Leu Gly 
            100                 105                 110         


His Leu Lys Ile Met His Asp Ala Ile Gly Phe Arg Ser Thr Leu Thr 
        115                 120                 125             


Gly Lys Asn Tyr Thr Met Glu Trp Tyr Glu Leu Phe Gln Leu Gly Asn 
    130                 135                 140                 


Cys Thr Phe Pro His Leu Arg Pro Glu Met Asp Ala Pro Phe Trp Cys 
145                 150                 155                 160 


Asn Gln Gly Ala Ala Cys Phe Phe Glu Gly Ile Asp Asp Val His Trp 
                165                 170                 175     


Lys Glu Asn Gly Thr Leu Val Gln Val Ala Thr Ile Ser Gly Phe His 
            180                 185                 190         


His Val Gly Gln Asp Ser Ile Glu Leu Arg Thr Ser Ser Asp Pro Pro 
        195                 200                 205             


Ile Leu Ala Ser Gln Ser Ala Gly Ile Thr Asp Val Ser His Cys Thr 
    210                 215                 220                 


Arg Pro Thr Ile Arg Ile Leu Pro Gln Arg Gly Thr Leu Tyr Tyr Leu 
225                 230                 235                 240 


Arg Trp Val Leu Leu Cys Cys Pro Gly 
                245                 


<210>  3046
<211>  205
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3046

Xaa Gln Ala Ser Arg Gly Ser Gly Ser Thr Gly Cys Ser Leu Met Ala 
1               5                   10                  15      


Gln Glu Val Asp Thr Ala Gln Gly Ala Glu Met Arg Arg Gly Ala Gly 
            20                  25                  30          


Ala Ala Arg Gly Arg Ala Ser Trp Cys Trp Ala Leu Ala Leu Leu Trp 
        35                  40                  45              


Leu Ala Val Val Pro Gly Trp Ser Arg Val Ser Gly Ile Pro Ser Arg 
    50                  55                  60                  


Arg His Trp Pro Val Pro Tyr Lys Arg Phe Asp Phe Arg Pro Lys Pro 
65                  70                  75                  80  


Asp Pro Tyr Cys Gln Ala Lys Tyr Thr Phe Cys Pro Thr Gly Ser Pro 
                85                  90                  95      


Ile Pro Val Met Glu Gly Asp Asp Asp Ile Glu Val Phe Arg Leu Gln 
            100                 105                 110         


Ala Pro Val Trp Glu Phe Lys Tyr Gly Asp Leu Leu Gly His Leu Lys 
        115                 120                 125             


Ile Met His Asp Ala Ile Gly Phe Arg Ser Thr Leu Thr Gly Lys Asn 
    130                 135                 140                 


Tyr Thr Met Glu Trp Tyr Glu Leu Phe Gln Leu Gly Asn Cys Thr Phe 
145                 150                 155                 160 


Pro His Leu Arg Pro Glu Met Asp Ala Pro Phe Trp Cys Asn Gln Gly 
                165                 170                 175     


Ala Ala Cys Phe Phe Glu Gly Ile Asp Asp Val His Trp Lys Glu Asn 
            180                 185                 190         


Gly Thr Leu Val Gln Val Ala Thr Ile Ser Gly Lys Leu 
        195                 200                 205 


<210>  3047
<211>  210
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3047

Xaa Ser Leu Met Ala Gln Glu Val Asp Thr Ala Gln Gly Ala Glu Met 
1               5                   10                  15      


Arg Arg Gly Ala Gly Ala Ala Arg Gly Arg Ala Ser Trp Cys Trp Ala 
            20                  25                  30          


Leu Ala Leu Leu Trp Leu Ala Val Val Pro Gly Trp Ser Arg Val Ser 
        35                  40                  45              


Gly Ile Pro Ser Arg Arg His Trp Pro Val Pro Tyr Lys Arg Phe Asp 
    50                  55                  60                  


Phe Arg Pro Lys Pro Asp Pro Tyr Cys Gln Ala Lys Tyr Thr Phe Cys 
65                  70                  75                  80  


Pro Thr Gly Ser Pro Ile Pro Val Met Glu Gly Asp Asp Asp Ile Glu 
                85                  90                  95      


Val Phe Arg Leu Gln Ala Pro Val Trp Glu Phe Lys Tyr Gly Asp Leu 
            100                 105                 110         


Leu Gly His Leu Lys Ile Met His Asp Ala Ile Gly Phe Arg Ser Thr 
        115                 120                 125             


Leu Thr Gly Lys Asn Tyr Thr Met Glu Trp Tyr Glu Leu Phe Gln Leu 
    130                 135                 140                 


Gly Asn Cys Thr Phe Pro His Leu Arg Pro Glu Met Asp Ala Pro Phe 
145                 150                 155                 160 


Trp Cys Asn Gln Gly Ala Ala Cys Phe Phe Glu Gly Ile Asp Asp Val 
                165                 170                 175     


His Trp Lys Glu Asn Gly Thr Leu Val Gln Val Ala Thr Ile Ser Glu 
            180                 185                 190         


Ile Ser Cys Ala Leu Lys Asn Gly Ile Lys Leu Ala Glu Leu Gly Phe 
        195                 200                 205             


Leu Leu 
    210 


<210>  3048
<211>  112
<212>  PRT
<213>  Homo Sapiens

<400>  3048

Met Glu Lys Ile Leu Ile Leu Leu Leu Val Ala Leu Ser Val Ala Tyr 
1               5                   10                  15      


Ala Ala Pro Gly Pro Arg Gly Ile Ile Ile Asn Leu Glu Asn Gly Glu 
            20                  25                  30          


Leu Cys Met Asn Ser Ala Gln Cys Lys Ser Asn Cys Cys Gln His Ser 
        35                  40                  45              


Ser Ala Leu Gly Leu Ala Arg Cys Thr Ser Met Ala Ser Glu Asn Ser 
    50                  55                  60                  


Glu Cys Ser Val Lys Thr Leu Tyr Gly Ile Tyr Tyr Lys Cys Pro Cys 
65                  70                  75                  80  


Glu Arg Gly Leu Thr Cys Glu Gly Asp Lys Thr Ile Val Gly Ser Ile 
                85                  90                  95      


Thr Asn Thr Asn Phe Gly Ile Cys His Asp Ala Gly Arg Ser Lys Gln 
            100                 105                 110         


<210>  3049
<211>  71
<212>  PRT
<213>  Homo Sapiens

<400>  3049

Met Glu Lys Ile Leu Ile Leu Leu Leu Val Ala Leu Ser Val Ala Tyr 
1               5                   10                  15      


Ala Ala Pro Gly Pro Arg Gly Ile Ile Ile Asn Leu Thr Leu Tyr Gly 
            20                  25                  30          


Ile Tyr Tyr Lys Cys Pro Cys Glu Arg Gly Leu Thr Cys Glu Gly Asp 
        35                  40                  45              


Lys Thr Ile Val Gly Ser Ile Thr Asn Thr Asn Phe Gly Ile Cys His 
    50                  55                  60                  


Asp Ala Gly Arg Ser Lys Gln 
65                  70      


<210>  3050
<211>  98
<212>  PRT
<213>  Homo Sapiens

<400>  3050

Met Ile Leu Leu Pro Gln Pro Pro Lys Lys Leu Gly Leu Gln Glu Asn 
1               5                   10                  15      


Gly Glu Leu Cys Met Asn Ser Ala Gln Cys Lys Ser Asn Cys Cys Gln 
            20                  25                  30          


His Ser Ser Ala Leu Gly Leu Ala Arg Cys Thr Ser Met Ala Ser Glu 
        35                  40                  45              


Asn Ser Glu Cys Ser Val Lys Thr Leu Tyr Gly Ile Tyr Tyr Lys Cys 
    50                  55                  60                  


Pro Cys Glu Arg Gly Leu Thr Cys Glu Gly Asp Lys Thr Ile Val Gly 
65                  70                  75                  80  


Ser Ile Thr Asn Thr Asn Phe Gly Ile Cys His Asp Ala Gly Arg Ser 
                85                  90                  95      


Lys Gln 
        


<210>  3051
<211>  42
<212>  PRT
<213>  Homo Sapiens

<400>  3051

Gly Cys Cys Gln Arg Ala Pro Asp Asn Cys Glu Ser His Cys Ala Glu 
1               5                   10                  15      


Lys Gly Ser Glu Gly Ser Leu Cys Gln Thr Gln Leu Pro Ala Thr Pro 
            20                  25                  30          


Cys Phe Leu Pro Ser Asn Thr Val Arg Thr 
        35                  40          


<210>  3052
<211>  121
<212>  PRT
<213>  Homo Sapiens

<400>  3052

Met Met Leu Pro Gln Trp Leu Leu Leu Leu Phe Leu Leu Phe Phe Phe 
1               5                   10                  15      


Leu Phe Leu Leu Thr Arg Gly Ser Leu Ser Pro Thr Lys Tyr Asn Leu 
            20                  25                  30          


Leu Glu Leu Lys Glu Ser Cys Ile Arg Asn Gln Asp Cys Glu Thr Gly 
        35                  40                  45              


Cys Cys Gln Arg Ala Pro Asp Asn Cys Glu Ser His Cys Ala Glu Lys 
    50                  55                  60                  


Gly Ser Glu Gly Ser Leu Cys Gln Thr Gln Val Phe Phe Gly Gln Tyr 
65                  70                  75                  80  


Arg Ala Cys Pro Cys Leu Arg Asn Leu Thr Cys Ile Tyr Ser Lys Asn 
                85                  90                  95      


Glu Lys Trp Leu Ser Ile Ala Tyr Gly Arg Cys Gln Lys Ile Gly Arg 
            100                 105                 110         


Gln Lys Leu Ala Lys Lys Met Phe Phe 
        115                 120     


<210>  3053
<211>  100
<212>  PRT
<213>  Homo Sapiens

<400>  3053

Met Ala Ala Ala Leu Ala Leu Val Ala Gly Val Leu Ser Gly Ala Val 
1               5                   10                  15      


Leu Pro Leu Trp Ser Ala Leu Pro Gln Tyr Lys Lys Lys Ile Thr Asp 
            20                  25                  30          


Arg Cys Phe His His Ser Glu Cys Tyr Ser Gly Cys Cys Leu Met Asp 
        35                  40                  45              


Leu Asp Ser Gly Gly Ala Phe Cys Ala Pro Arg Ala Arg Ile Thr Met 
    50                  55                  60                  


Ile Cys Leu Pro Gln Thr Lys Gly Ala Thr Asn Ile Ile Cys Pro Cys 
65                  70                  75                  80  


Arg Met Gly Leu Thr Cys Ile Ser Lys Asp Leu Met Cys Ser Arg Arg 
                85                  90                  95      


Cys His Met Ile 
            100 


<210>  3054
<211>  153
<212>  PRT
<213>  Homo Sapiens

<400>  3054

Met Ala Ala Ala Leu Ala Leu Val Ala Gly Val Leu Ser Gly Ala Val 
1               5                   10                  15      


Leu Pro Leu Trp Ser Ala Leu Pro Gln Tyr Lys Lys Lys Ile Thr Asp 
            20                  25                  30          


Arg Cys Phe His His Ser Glu Cys Tyr Ser Gly Cys Cys Leu Met Asp 
        35                  40                  45              


Leu Asp Ser Gly Gly Ala Phe Cys Ala Pro Arg Ala Arg Ile Thr Met 
    50                  55                  60                  


Ile Cys Leu Pro Gln Trp Leu Glu Leu Phe Lys Gly Arg Asp Arg Ile 
65                  70                  75                  80  


Ile Phe Ile Tyr Glu Ala Pro Thr Pro Ser Leu Val Ser Ala His Asn 
                85                  90                  95      


Gln Gly Ser Tyr Gln His His Leu Pro Leu Pro Asp Gly Leu Asp Val 
            100                 105                 110         


His Ile Gln Gly Leu Asp Val Phe Pro Pro Val Pro Tyr Asp Leu Glu 
        115                 120                 125             


Glu Asp Ala Gly Trp Ser Leu Leu Pro Trp Gly His Arg Pro Trp Leu 
    130                 135                 140                 


Pro Pro Thr Cys Ser Lys Ser Ser Ser 
145                 150             


<210>  3055
<211>  633
<212>  PRT
<213>  Homo Sapiens

<400>  3055

Met Pro Ser Cys Gly Ala Cys Thr Cys Gly Ala Ala Ala Val Arg Leu 
1               5                   10                  15      


Ile Thr Ser Ser Leu Ala Ser Ala Gln Arg Gly Ile Ser Gly Gly Arg 
            20                  25                  30          


Ile His Met Ser Val Leu Gly Arg Leu Gly Thr Phe Glu Thr Gln Ile 
        35                  40                  45              


Leu Gln Arg Ala Pro Leu Arg Ser Phe Thr Glu Thr Pro Ala Tyr Phe 
    50                  55                  60                  


Ala Ser Lys Asp Gly Ile Ser Lys Asp Gly Ser Gly Asp Gly Asn Lys 
65                  70                  75                  80  


Lys Ser Ala Ser Glu Gly Ser Ser Lys Lys Ser Gly Ser Gly Asn Ser 
                85                  90                  95      


Gly Lys Gly Gly Asn Gln Leu Arg Cys Pro Lys Cys Gly Asp Leu Cys 
            100                 105                 110         


Thr His Val Glu Thr Phe Val Ser Ser Thr Arg Phe Val Lys Cys Glu 
        115                 120                 125             


Lys Cys His His Phe Phe Val Val Leu Ser Glu Ala Asp Ser Lys Lys 
    130                 135                 140                 


Ser Ile Ile Lys Glu Pro Glu Ser Ala Ala Glu Ala Val Lys Leu Ala 
145                 150                 155                 160 


Phe Gln Gln Lys Pro Pro Pro Pro Pro Lys Lys Ile Tyr Asn Tyr Leu 
                165                 170                 175     


Asp Lys Tyr Val Val Gly Gln Ser Phe Ala Lys Lys Val Leu Ser Val 
            180                 185                 190         


Ala Val Tyr Asn His Tyr Lys Arg Ile Tyr Asn Asn Ile Pro Ala Asn 
        195                 200                 205             


Leu Arg Gln Gln Ala Glu Val Glu Lys Gln Thr Ser Leu Thr Pro Arg 
    210                 215                 220                 


Glu Leu Glu Ile Arg Arg Arg Glu Asp Glu Tyr Arg Phe Thr Lys Leu 
225                 230                 235                 240 


Leu Gln Ile Ala Gly Ile Ser Pro His Gly Asn Ala Leu Gly Ala Ser 
                245                 250                 255     


Met Gln Gln Gln Val Asn Gln Gln Ile Pro Gln Glu Lys Arg Gly Gly 
            260                 265                 270         


Glu Val Leu Asp Ser Ser His Asp Asp Ile Lys Leu Glu Lys Ser Asn 
        275                 280                 285             


Ile Leu Leu Leu Gly Pro Thr Gly Ser Gly Lys Thr Leu Leu Ala Gln 
    290                 295                 300                 


Thr Leu Ala Lys Cys Leu Asp Val Pro Phe Ala Ile Cys Asp Cys Thr 
305                 310                 315                 320 


Thr Leu Thr Gln Ala Gly Tyr Val Gly Glu Asp Ile Glu Ser Val Ile 
                325                 330                 335     


Ala Lys Leu Leu Gln Asp Ala Asn Tyr Asn Val Glu Lys Ala Gln Gln 
            340                 345                 350         


Gly Ile Val Phe Leu Asp Glu Val Asp Lys Ile Gly Ser Val Pro Gly 
        355                 360                 365             


Ile His Gln Leu Arg Asp Val Gly Gly Glu Gly Val Gln Gln Gly Leu 
    370                 375                 380                 


Leu Lys Leu Leu Glu Gly Thr Ile Val Asn Val Pro Glu Lys Asn Ser 
385                 390                 395                 400 


Arg Lys Leu Arg Gly Glu Thr Val Gln Val Asp Thr Thr Asn Ile Leu 
                405                 410                 415     


Phe Val Ala Ser Gly Ala Phe Asn Gly Leu Asp Arg Ile Ile Ser Arg 
            420                 425                 430         


Arg Lys Asn Glu Lys Tyr Leu Gly Phe Gly Thr Pro Ser Asn Leu Gly 
        435                 440                 445             


Lys Gly Arg Arg Ala Ala Ala Ala Ala Asp Leu Ala Asn Arg Ser Gly 
    450                 455                 460                 


Glu Ser Asn Thr His Gln Asp Ile Glu Glu Lys Asp Arg Leu Leu Arg 
465                 470                 475                 480 


His Val Glu Ala Arg Asp Leu Ile Glu Phe Gly Met Ile Pro Glu Phe 
                485                 490                 495     


Val Gly Arg Leu Pro Val Val Val Pro Leu His Ser Leu Asp Glu Lys 
            500                 505                 510         


Thr Leu Val Gln Ile Leu Thr Glu Pro Arg Asn Ala Val Ile Pro Gln 
        515                 520                 525             


Tyr Gln Ala Leu Phe Ser Met Asp Lys Cys Glu Leu Asn Val Thr Glu 
    530                 535                 540                 


Asp Ala Leu Lys Ala Ile Ala Arg Leu Ala Leu Glu Arg Lys Thr Gly 
545                 550                 555                 560 


Ala Arg Gly Leu Arg Ser Ile Met Glu Lys Leu Leu Leu Glu Pro Met 
                565                 570                 575     


Phe Glu Val Pro Asn Ser Asp Ile Val Cys Val Glu Val Asp Lys Glu 
            580                 585                 590         


Val Val Glu Gly Lys Lys Glu Pro Gly Tyr Ile Arg Ala Pro Thr Lys 
        595                 600                 605             


Glu Ser Ser Glu Glu Glu Tyr Asp Ser Gly Val Glu Glu Glu Gly Trp 
    610                 615                 620                 


Pro Arg Gln Ala Asp Ala Ala Asn Ser 
625                 630             


<210>  3056
<211>  268
<212>  PRT
<213>  Homo Sapiens

<400>  3056

Met Pro Ser Cys Gly Ala Cys Thr Cys Gly Ala Ala Ala Val Arg Leu 
1               5                   10                  15      


Ile Thr Ser Ser Leu Ala Ser Ala Gln Arg Gly Ile Ser Gly Gly Arg 
            20                  25                  30          


Ile His Met Ser Val Leu Gly Arg Leu Gly Thr Phe Glu Thr Gln Ile 
        35                  40                  45              


Leu Gln Arg Ala Pro Leu Arg Ser Phe Thr Glu Thr Pro Ala Tyr Phe 
    50                  55                  60                  


Ala Ser Lys Asp Gly Ile Ser Lys Asp Gly Ser Gly Asp Gly Asn Lys 
65                  70                  75                  80  


Lys Ser Ala Ser Glu Gly Ser Ser Lys Lys Ser Gly Ser Gly Asn Ser 
                85                  90                  95      


Gly Lys Gly Gly Asn Gln Leu Arg Cys Pro Lys Cys Gly Asp Leu Cys 
            100                 105                 110         


Thr His Val Glu Thr Phe Val Ser Ser Thr Arg Phe Val Lys Cys Glu 
        115                 120                 125             


Lys Cys His His Phe Phe Val Val Leu Ser Glu Ala Asp Ser Lys Lys 
    130                 135                 140                 


Ser Ile Ile Lys Glu Pro Glu Ser Ala Ala Glu Ala Val Lys Leu Ala 
145                 150                 155                 160 


Phe Gln Gln Lys Pro Pro Pro Pro Pro Lys Lys Ile Tyr Asn Tyr Leu 
                165                 170                 175     


Asp Lys Tyr Val Val Gly Gln Ser Phe Ala Lys Lys Val Leu Ser Val 
            180                 185                 190         


Ala Val Tyr Asn His Tyr Lys Arg Ile Tyr Asn Asn Ile Pro Ala Asn 
        195                 200                 205             


Leu Arg Gln Gln Ala Glu Val Glu Lys Gln Thr Ser Leu Thr Pro Arg 
    210                 215                 220                 


Glu Leu Glu Ile Arg Arg Arg Glu Asp Glu Tyr Arg Phe Thr Lys Leu 
225                 230                 235                 240 


Leu Gln Ile Ala Gly Ile Ser Pro His Gly Asn Ala Leu Gly Ala Ser 
                245                 250                 255     


Met Gln Gln Gln Val Lys Leu Cys Trp His Lys Pro 
            260                 265             


<210>  3057
<211>  130
<212>  PRT
<213>  Homo Sapiens

<400>  3057

Met Ser Val Leu Gly Arg Leu Gly Thr Phe Glu Thr Gln Ile Leu Gln 
1               5                   10                  15      


Arg Ala Pro Leu Arg Ser Phe Thr Glu Thr Pro Ala Tyr Phe Ala Ser 
            20                  25                  30          


Lys Asp Gly Ile Ser Lys Asp Gly Ser Gly Asp Gly Asn Lys Lys Ser 
        35                  40                  45              


Ala Ser Glu Gly Ser Ser Lys Lys Ser Gly Ser Gly Asn Ser Gly Lys 
    50                  55                  60                  


Gly Gly Asn Gln Leu Arg Cys Pro Lys Cys Gly Asp Leu Cys Thr His 
65                  70                  75                  80  


Val Glu Thr Phe Val Ser Ser Thr Arg Phe Val Lys Cys Glu Lys Cys 
                85                  90                  95      


His His Phe Phe Val Val Leu Ser Glu Ala Asp Ser Lys Lys Ser Ile 
            100                 105                 110         


Ile Lys Glu Pro Glu Ser Ala Ala Glu Ala Val Lys Leu Ala Phe Gln 
        115                 120                 125             


Gln Lys 
    130 


<210>  3058
<211>  129
<212>  PRT
<213>  Homo Sapiens

<400>  3058

Met Glu Asn Asp Asn Thr Val Leu Leu Asn Pro Pro Leu Phe Ala Leu 
1               5                   10                  15      


Asp Lys Asp Ala Pro Leu Arg Tyr Ala Gly Glu Ile Cys Gly Phe Arg 
            20                  25                  30          


Leu His Gly Ser Gly Val Pro Phe Glu Ala Val Ile Leu Asp Lys Ala 
        35                  40                  45              


Thr Gly Glu Gly Leu Ile Arg Ala Lys Glu Pro Val Asp Cys Glu Ala 
    50                  55                  60                  


Gln Lys Glu His Thr Phe Thr Ile Gln Ala Tyr Asp Cys Gly Glu Gly 
65                  70                  75                  80  


Pro Asp Gly Ala Asn Thr Lys Lys Ser His Lys Ala Thr Val His Val 
                85                  90                  95      


Arg Val Asn Asp Val Asn Glu Phe Ala Pro Val Phe Val Glu Arg Leu 
            100                 105                 110         


Tyr Arg Ala Ala Val Thr Glu Gly Lys Leu Tyr Asp Arg Ile Leu Arg 
        115                 120                 125             


Val 
    


<210>  3059
<211>  142
<212>  PRT
<213>  Homo Sapiens

<400>  3059

Met Glu Asn Asp Asn Thr Val Leu Leu Asn Pro Pro Leu Phe Ala Leu 
1               5                   10                  15      


Asp Lys Asp Ala Pro Leu Arg Tyr Ala Gly Glu Ile Cys Gly Phe Arg 
            20                  25                  30          


Leu His Gly Ser Gly Val Pro Phe Glu Ala Val Ile Leu Asp Lys Ala 
        35                  40                  45              


Thr Gly Glu Gly Leu Ile Arg Ala Lys Glu Pro Val Asp Cys Glu Ala 
    50                  55                  60                  


Gln Lys Glu His Thr Phe Thr Ile Gln Ala Tyr Asp Cys Gly Glu Gly 
65                  70                  75                  80  


Pro Asp Gly Ala Asn Thr Lys Lys Ser His Lys Ala Thr Val His Val 
                85                  90                  95      


Arg Val Asn Asp Val Asn Glu Phe Ala Pro Val Phe Val Glu Arg Leu 
            100                 105                 110         


Tyr Arg Ala Ala Val Thr Glu Gly Lys Leu Tyr Asp Arg Ile Leu Arg 
        115                 120                 125             


Val Glu Ala Ile Asp Gly Asp Cys Ser Pro Gln Tyr Ser Gln 
    130                 135                 140         


<210>  3060
<211>  154
<212>  PRT
<213>  Homo Sapiens

<400>  3060

Met Glu Asn Asp Asn Thr Val Leu Leu Asn Pro Pro Leu Phe Ala Leu 
1               5                   10                  15      


Asp Lys Asp Ala Pro Leu Arg Tyr Ala Gly Glu Ile Cys Gly Phe Arg 
            20                  25                  30          


Leu His Gly Ser Gly Val Pro Phe Glu Ala Val Ile Leu Asp Lys Ala 
        35                  40                  45              


Thr Gly Glu Gly Leu Ile Arg Ala Lys Glu Pro Val Asp Cys Glu Ala 
    50                  55                  60                  


Gln Lys Glu His Thr Phe Thr Ile Gln Ala Tyr Asp Cys Gly Glu Gly 
65                  70                  75                  80  


Pro Asp Gly Ala Asn Thr Lys Lys Ser His Lys Ala Thr Val His Val 
                85                  90                  95      


Arg Val Asn Asp Val Asn Glu Phe Ala Pro Val Phe Val Glu Arg Leu 
            100                 105                 110         


Tyr Arg Ala Ala Val Thr Glu Gly Lys Leu Tyr Asp Arg Ile Leu Arg 
        115                 120                 125             


Val Glu Ala Ile Asp Gly Asp Cys Ser Pro Gln Tyr Ser Gln Ile Cys 
    130                 135                 140                 


Tyr Tyr Glu Ile Leu Thr Pro Asn Thr Pro 
145                 150                 


<210>  3061
<211>  134
<212>  PRT
<213>  Homo Sapiens

<400>  3061

Met Thr Leu Leu Leu Leu Pro Leu Leu Leu Ala Ser Leu Leu Ala Ser 
1               5                   10                  15      


Cys Ser Cys Asn Lys Ala Asn Lys His Lys Pro Trp Ile Glu Ala Glu 
            20                  25                  30          


Tyr Gln Gly Ile Val Met Glu Asn Asp Asn Thr Val Leu Leu Asn Pro 
        35                  40                  45              


Pro Leu Phe Ala Leu Asp Lys Asp Ala Pro Leu Arg Tyr Ala Gly Glu 
    50                  55                  60                  


Ile Cys Gly Phe Arg Leu His Gly Ser Gly Val Pro Phe Glu Ala Val 
65                  70                  75                  80  


Ile Leu Asp Lys Ala Thr Gly Glu Gly Leu Ile Arg Ala Lys Glu Pro 
                85                  90                  95      


Val Asp Cys Glu Ala Gln Lys Glu His Thr Phe Thr Ile Gln Ala Tyr 
            100                 105                 110         


Asp Cys Gly Glu Gly Pro Asp Gly Ala Asn Thr Lys Lys Ser His Lys 
        115                 120                 125             


Ala Thr Val His Val Arg 
    130                 


<210>  3062
<211>  956
<212>  PRT
<213>  Homo Sapiens

<400>  3062

Met Thr Leu Leu Leu Leu Pro Leu Leu Leu Ala Ser Leu Leu Ala Ser 
1               5                   10                  15      


Cys Ser Cys Asn Lys Ala Asn Lys His Lys Pro Trp Ile Glu Ala Glu 
            20                  25                  30          


Tyr Gln Gly Ile Val Met Glu Asn Asp Asn Thr Val Leu Leu Asn Pro 
        35                  40                  45              


Pro Leu Phe Ala Leu Asp Lys Asp Ala Pro Leu Arg Tyr Ala Gly Glu 
    50                  55                  60                  


Ile Cys Gly Phe Arg Leu His Gly Ser Gly Val Pro Phe Glu Ala Val 
65                  70                  75                  80  


Ile Leu Asp Lys Ala Thr Gly Glu Gly Leu Ile Arg Ala Lys Glu Pro 
                85                  90                  95      


Val Asp Cys Glu Ala Gln Lys Glu His Thr Phe Thr Ile Gln Ala Tyr 
            100                 105                 110         


Asp Cys Gly Glu Gly Pro Asp Gly Ala Asn Thr Lys Lys Ser His Lys 
        115                 120                 125             


Ala Thr Val His Val Arg Val Asn Asp Val Asn Glu Phe Ala Pro Val 
    130                 135                 140                 


Phe Val Glu Arg Leu Tyr Arg Ala Ala Val Thr Glu Gly Lys Leu Tyr 
145                 150                 155                 160 


Asp Arg Ile Leu Arg Val Glu Ala Ile Asp Gly Asp Cys Ser Pro Gln 
                165                 170                 175     


Tyr Ser Gln Ile Cys Tyr Tyr Glu Ile Leu Thr Pro Asn Thr Pro Phe 
            180                 185                 190         


Leu Ile Asp Asn Asp Gly Asn Ile Glu Asn Thr Glu Lys Leu Gln Tyr 
        195                 200                 205             


Ser Gly Glu Arg Leu Tyr Lys Phe Thr Val Thr Ala Tyr Asp Cys Gly 
    210                 215                 220                 


Lys Lys Arg Ala Ala Asp Asp Ala Glu Val Glu Ile Gln Val Lys Pro 
225                 230                 235                 240 


Thr Cys Lys Pro Ser Trp Gln Gly Trp Asn Lys Arg Ile Glu Tyr Ala 
                245                 250                 255     


Pro Gly Ala Gly Ser Leu Ala Leu Phe Pro Gly Ile Arg Leu Glu Thr 
            260                 265                 270         


Cys Asp Glu Pro Leu Trp Asn Ile Gln Ala Thr Ile Glu Leu Gln Thr 
        275                 280                 285             


Ser His Val Ala Lys Gly Cys Asp Arg Asp Asn Tyr Ser Glu Arg Ala 
    290                 295                 300                 


Leu Arg Lys Leu Cys Gly Ala Ala Thr Gly Glu Val Asp Leu Leu Pro 
305                 310                 315                 320 


Met Pro Gly Pro Asn Ala Asn Trp Thr Ala Gly Leu Ser Val His Tyr 
                325                 330                 335     


Ser Gln Asp Ser Ser Leu Ile Tyr Trp Phe Asn Gly Thr Gln Ala Val 
            340                 345                 350         


Gln Val Pro Leu Gly Gly Pro Ser Gly Leu Gly Ser Gly Pro Gln Asp 
        355                 360                 365             


Ser Leu Ser Asp His Phe Thr Leu Ser Phe Trp Met Lys His Gly Val 
    370                 375                 380                 


Thr Pro Asn Lys Gly Lys Lys Glu Glu Glu Thr Ile Val Cys Asn Thr 
385                 390                 395                 400 


Val Gln Asn Glu Asp Gly Phe Ser His Tyr Ser Leu Thr Val His Gly 
                405                 410                 415     


Cys Arg Ile Ala Phe Leu Tyr Trp Pro Leu Leu Glu Ser Ala Arg Pro 
            420                 425                 430         


Val Lys Phe Leu Trp Lys Leu Glu Gln Val Cys Asp Asp Glu Trp His 
        435                 440                 445             


His Tyr Ala Leu Asn Leu Glu Phe Pro Thr Val Thr Leu Tyr Thr Asp 
    450                 455                 460                 


Gly Ile Ser Phe Asp Pro Ala Leu Ile His Asp Asn Gly Leu Ile His 
465                 470                 475                 480 


Pro Pro Arg Arg Glu Pro Ala Leu Met Ile Gly Ala Cys Trp Thr Glu 
                485                 490                 495     


Glu Lys Asn Lys Glu Lys Glu Lys Gly Asp Asn Ser Thr Asp Thr Thr 
            500                 505                 510         


Gln Gly Asp Pro Leu Ser Ile His His Tyr Phe His Gly Tyr Leu Ala 
        515                 520                 525             


Gly Phe Ser Val Arg Ser Gly Arg Leu Glu Ser Arg Glu Val Ile Glu 
    530                 535                 540                 


Cys Leu Tyr Ala Cys Arg Glu Gly Leu Asp Tyr Arg Asp Phe Glu Ser 
545                 550                 555                 560 


Leu Gly Lys Gly Met Lys Val His Val Asn Pro Ser Gln Ser Leu Leu 
                565                 570                 575     


Thr Leu Glu Gly Asp Asp Val Glu Thr Phe Asn His Ala Leu Gln His 
            580                 585                 590         


Val Ala Tyr Met Asn Thr Leu Arg Phe Ala Thr Pro Gly Val Arg Pro 
        595                 600                 605             


Leu Arg Leu Thr Thr Ala Val Lys Cys Phe Ser Glu Glu Ser Cys Val 
    610                 615                 620                 


Ser Ile Pro Glu Val Glu Gly Tyr Val Val Val Leu Gln Pro Asp Ala 
625                 630                 635                 640 


Pro Gln Ile Leu Leu Ser Gly Thr Ala His Phe Ala Arg Pro Ala Val 
                645                 650                 655     


Asp Phe Glu Gly Thr Asn Gly Val Pro Leu Phe Pro Asp Leu Gln Ile 
            660                 665                 670         


Thr Cys Ser Ile Ser His Gln Val Glu Ala Lys Lys Asp Glu Ser Trp 
        675                 680                 685             


Gln Gly Thr Val Thr Asp Thr Arg Met Ser Asp Glu Ile Val His Asn 
    690                 695                 700                 


Leu Asp Gly Cys Glu Ile Ser Leu Val Gly Asp Asp Leu Asp Pro Glu 
705                 710                 715                 720 


Arg Glu Ser Leu Leu Leu Asp Thr Thr Ser Leu Gln Gln Arg Gly Leu 
                725                 730                 735     


Glu Leu Thr Asn Thr Ser Ala Tyr Leu Thr Ile Ala Gly Val Glu Ser 
            740                 745                 750         


Ile Thr Val Tyr Glu Glu Ile Leu Arg Gln Ala Arg Tyr Arg Leu Arg 
        755                 760                 765             


His Gly Ala Ala Leu Tyr Thr Arg Lys Phe Arg Leu Ser Cys Ser Glu 
    770                 775                 780                 


Met Asn Gly Arg Tyr Ser Ser Asn Glu Phe Ile Val Glu Val Asn Val 
785                 790                 795                 800 


Leu His Ser Met Asn Arg Val Ala His Pro Ser His Val Leu Ser Ser 
                805                 810                 815     


Gln Gln Phe Leu His Arg Gly His Gln Pro Pro Pro Glu Met Ala Gly 
            820                 825                 830         


His Ser Leu Ala Ser Ser His Arg Asn Ser Met Ile Pro Ser Ala Ala 
        835                 840                 845             


Thr Leu Ile Ile Val Val Cys Val Gly Phe Leu Val Leu Met Val Val 
    850                 855                 860                 


Leu Gly Leu Val Arg Ile His Ser Leu His Arg Arg Val Ser Gly Ala 
865                 870                 875                 880 


Gly Gly Pro Pro Gly Ala Ser Ser Asp Pro Lys Asp Pro Asp Leu Phe 
                885                 890                 895     


Trp Asp Asp Ser Ala Leu Thr Ile Ile Val Asn Pro Met Glu Ser Tyr 
            900                 905                 910         


Gln Asn Arg Gln Ser Cys Val Thr Gly Ala Val Gly Gly Gln Gln Glu 
        915                 920                 925             


Asp Glu Asp Ser Ser Asp Ser Glu Val Ala Asp Ser Pro Ser Ser Asp 
    930                 935                 940                 


Glu Arg Arg Ile Ile Glu Thr Pro Pro His Arg Tyr 
945                 950                 955     


<210>  3063
<211>  968
<212>  PRT
<213>  Homo Sapiens

<400>  3063

Met Val Leu Gly Cys Glu Leu Ser Gly Ser Thr Arg Val Val Val Gly 
1               5                   10                  15      


Val Glu Ala Leu Leu Thr Gly Ala Ser Ser Pro Leu Pro Gly Val Gly 
            20                  25                  30          


Pro Ala Asn Lys His Lys Pro Trp Ile Glu Ala Glu Tyr Gln Gly Ile 
        35                  40                  45              


Val Met Glu Asn Asp Asn Thr Val Leu Leu Asn Pro Pro Leu Phe Ala 
    50                  55                  60                  


Leu Asp Lys Asp Ala Pro Leu Arg Tyr Ala Gly Glu Ile Cys Gly Phe 
65                  70                  75                  80  


Arg Leu His Gly Ser Gly Val Pro Phe Glu Ala Val Ile Leu Asp Lys 
                85                  90                  95      


Ala Thr Gly Glu Gly Leu Ile Arg Ala Lys Glu Pro Val Asp Cys Glu 
            100                 105                 110         


Ala Gln Lys Glu His Thr Phe Thr Ile Gln Ala Tyr Asp Cys Gly Glu 
        115                 120                 125             


Gly Pro Asp Gly Ala Asn Thr Lys Lys Ser His Lys Ala Thr Val His 
    130                 135                 140                 


Val Arg Val Asn Asp Val Asn Glu Phe Ala Pro Val Phe Val Glu Arg 
145                 150                 155                 160 


Leu Tyr Arg Ala Ala Val Thr Glu Gly Lys Leu Tyr Asp Arg Ile Leu 
                165                 170                 175     


Arg Val Glu Ala Ile Asp Gly Asp Cys Ser Pro Gln Tyr Ser Gln Ile 
            180                 185                 190         


Cys Tyr Tyr Glu Ile Leu Thr Pro Asn Thr Pro Phe Leu Ile Asp Asn 
        195                 200                 205             


Asp Gly Asn Ile Glu Asn Thr Glu Lys Leu Gln Tyr Ser Gly Glu Arg 
    210                 215                 220                 


Leu Tyr Lys Phe Thr Val Thr Ala Tyr Asp Cys Gly Lys Lys Arg Ala 
225                 230                 235                 240 


Ala Asp Asp Ala Glu Val Glu Ile Gln Val Lys Pro Thr Cys Lys Pro 
                245                 250                 255     


Ser Trp Gln Gly Trp Asn Lys Arg Ile Glu Tyr Ala Pro Gly Ala Gly 
            260                 265                 270         


Ser Leu Ala Leu Phe Pro Gly Ile Arg Leu Glu Thr Cys Asp Glu Pro 
        275                 280                 285             


Leu Trp Asn Ile Gln Ala Thr Ile Glu Leu Gln Thr Ser His Val Ala 
    290                 295                 300                 


Lys Gly Cys Asp Arg Asp Asn Tyr Ser Glu Arg Ala Leu Arg Lys Leu 
305                 310                 315                 320 


Cys Gly Ala Ala Thr Gly Glu Val Asp Leu Leu Pro Met Pro Gly Pro 
                325                 330                 335     


Asn Ala Asn Trp Thr Ala Gly Leu Ser Val His Tyr Ser Gln Asp Ser 
            340                 345                 350         


Ser Leu Ile Tyr Trp Phe Asn Gly Thr Gln Ala Val Gln Val Pro Leu 
        355                 360                 365             


Gly Gly Pro Ser Gly Leu Gly Ser Gly Pro Gln Asp Ser Leu Ser Asp 
    370                 375                 380                 


His Phe Thr Leu Ser Phe Trp Met Lys His Gly Val Thr Pro Asn Lys 
385                 390                 395                 400 


Gly Lys Lys Glu Glu Glu Thr Ile Val Cys Asn Thr Val Gln Asn Glu 
                405                 410                 415     


Asp Gly Phe Ser His Tyr Ser Leu Thr Val His Gly Cys Arg Ile Ala 
            420                 425                 430         


Phe Leu Tyr Trp Pro Leu Leu Glu Ser Ala Arg Pro Val Lys Phe Leu 
        435                 440                 445             


Trp Lys Leu Glu Gln Val Cys Asp Asp Glu Trp His His Tyr Ala Leu 
    450                 455                 460                 


Asn Leu Glu Phe Pro Thr Val Thr Leu Tyr Thr Asp Gly Ile Ser Phe 
465                 470                 475                 480 


Asp Pro Ala Leu Ile His Asp Asn Gly Leu Ile His Pro Pro Arg Arg 
                485                 490                 495     


Glu Pro Ala Leu Met Ile Gly Ala Cys Trp Thr Glu Glu Lys Asn Lys 
            500                 505                 510         


Glu Lys Glu Lys Gly Asp Asn Ser Thr Asp Thr Thr Gln Gly Asp Pro 
        515                 520                 525             


Leu Ser Ile His His Tyr Phe His Gly Tyr Leu Ala Gly Phe Ser Val 
    530                 535                 540                 


Arg Ser Gly Arg Leu Glu Ser Arg Glu Val Ile Glu Cys Leu Tyr Ala 
545                 550                 555                 560 


Cys Arg Glu Gly Leu Asp Tyr Arg Asp Phe Glu Ser Leu Gly Lys Gly 
                565                 570                 575     


Met Lys Val His Val Asn Pro Ser Gln Ser Leu Leu Thr Leu Glu Gly 
            580                 585                 590         


Asp Asp Val Glu Thr Phe Asn His Ala Leu Gln His Val Ala Tyr Met 
        595                 600                 605             


Asn Thr Leu Arg Phe Ala Thr Pro Gly Val Arg Pro Leu Arg Leu Thr 
    610                 615                 620                 


Thr Ala Val Lys Cys Phe Ser Glu Glu Ser Cys Val Ser Ile Pro Glu 
625                 630                 635                 640 


Val Glu Gly Tyr Val Val Val Leu Gln Pro Asp Ala Pro Gln Ile Leu 
                645                 650                 655     


Leu Ser Gly Thr Ala His Phe Ala Arg Pro Ala Val Asp Phe Glu Gly 
            660                 665                 670         


Thr Asn Gly Val Pro Leu Phe Pro Asp Leu Gln Ile Thr Cys Ser Ile 
        675                 680                 685             


Ser His Gln Val Glu Ala Lys Lys Asp Glu Ser Trp Gln Gly Thr Val 
    690                 695                 700                 


Thr Asp Thr Arg Met Ser Asp Glu Ile Val His Asn Leu Asp Gly Cys 
705                 710                 715                 720 


Glu Ile Ser Leu Val Gly Asp Asp Leu Asp Pro Glu Arg Glu Ser Leu 
                725                 730                 735     


Leu Leu Asp Thr Thr Ser Leu Gln Gln Arg Gly Leu Glu Leu Thr Asn 
            740                 745                 750         


Thr Ser Ala Tyr Leu Thr Ile Ala Gly Val Glu Ser Ile Thr Val Tyr 
        755                 760                 765             


Glu Glu Ile Leu Arg Gln Ala Arg Tyr Arg Leu Arg His Gly Ala Ala 
    770                 775                 780                 


Leu Tyr Thr Arg Lys Phe Arg Leu Ser Cys Ser Glu Met Asn Gly Arg 
785                 790                 795                 800 


Tyr Ser Ser Asn Glu Phe Ile Val Glu Val Asn Val Leu His Ser Met 
                805                 810                 815     


Asn Arg Val Ala His Pro Ser His Val Leu Ser Ser Gln Gln Phe Leu 
            820                 825                 830         


His Arg Gly His Gln Pro Pro Pro Glu Met Ala Gly His Ser Leu Ala 
        835                 840                 845             


Ser Ser His Arg Asn Ser Met Ile Pro Ser Ala Ala Thr Leu Ile Ile 
    850                 855                 860                 


Val Val Cys Val Gly Phe Leu Val Leu Met Val Val Leu Gly Leu Val 
865                 870                 875                 880 


Arg Ile His Ser Leu His Arg Arg Val Ser Gly Ala Gly Gly Pro Pro 
                885                 890                 895     


Gly Ala Ser Ser Asp Pro Lys Asp Pro Asp Leu Phe Trp Asp Asp Ser 
            900                 905                 910         


Ala Leu Thr Ile Ile Val Asn Pro Met Glu Ser Tyr Gln Asn Arg Gln 
        915                 920                 925             


Ser Cys Val Thr Gly Ala Val Gly Gly Gln Gln Glu Asp Glu Asp Ser 
    930                 935                 940                 


Ser Asp Ser Glu Val Ala Asp Ser Pro Ser Ser Asp Glu Arg Arg Ile 
945                 950                 955                 960 


Ile Glu Thr Pro Pro His Arg Tyr 
                965             


<210>  3064
<211>  176
<212>  PRT
<213>  Homo Sapiens

<400>  3064

Met Val Val Ile Thr Asn Lys His Lys Pro Trp Ile Glu Ala Glu Tyr 
1               5                   10                  15      


Gln Gly Ile Val Met Glu Asn Asp Asn Thr Val Leu Leu Asn Pro Pro 
            20                  25                  30          


Leu Phe Ala Leu Asp Lys Asp Ala Pro Leu Arg Tyr Ala Gly Glu Ile 
        35                  40                  45              


Cys Gly Phe Arg Leu His Gly Ser Gly Val Pro Phe Glu Ala Val Ile 
    50                  55                  60                  


Leu Asp Lys Ala Thr Gly Glu Gly Leu Ile Arg Ala Lys Glu Pro Val 
65                  70                  75                  80  


Asp Cys Glu Ala Gln Lys Glu His Thr Phe Thr Ile Gln Ala Tyr Asp 
                85                  90                  95      


Cys Gly Glu Gly Pro Asp Gly Ala Asn Thr Lys Lys Ser His Lys Ala 
            100                 105                 110         


Thr Val His Val Arg Val Asn Asp Val Asn Glu Phe Ala Pro Val Phe 
        115                 120                 125             


Val Glu Arg Leu Tyr Arg Ala Ala Val Thr Glu Gly Lys Leu Tyr Asp 
    130                 135                 140                 


Arg Ile Leu Arg Val Glu Ala Ile Asp Gly Asp Cys Ser Pro Gln Tyr 
145                 150                 155                 160 


Ser Gln Ile Cys Tyr Tyr Glu Ile Leu Thr Pro Asn Thr Pro Phe Leu 
                165                 170                 175     


<210>  3065
<211>  297
<212>  PRT
<213>  Homo Sapiens

<400>  3065

Met Glu Ala Cys Lys Asp Ser Arg Ile Gly Gly Met Met Lys Thr Leu 
1               5                   10                  15      


Leu Leu Phe Val Gly Leu Leu Leu Thr Trp Glu Ser Gly Gln Val Leu 
            20                  25                  30          


Gly Asp Gln Thr Val Ser Asp Asn Glu Leu Gln Glu Met Ser Asn Gln 
        35                  40                  45              


Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn Ala Val Asn Gly Val 
    50                  55                  60                  


Lys Gln Ile Lys Thr Leu Ile Glu Lys Thr Asn Glu Glu Arg Lys Thr 
65                  70                  75                  80  


Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys Lys Glu Asp Ala Leu 
                85                  90                  95      


Asn Glu Thr Arg Glu Ser Glu Thr Lys Leu Lys Glu Leu Pro Gly Val 
            100                 105                 110         


Cys Asn Glu Thr Met Met Ala Leu Trp Glu Glu Cys Lys Pro Cys Leu 
        115                 120                 125             


Lys Gln Thr Cys Met Lys Phe Tyr Ala Arg Val Cys Arg Ser Gly Ser 
    130                 135                 140                 


Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu Asn Gln Ser Ser Pro 
145                 150                 155                 160 


Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp Ser Leu Leu Glu Asn 
                165                 170                 175     


Asp Arg Gln Gln Thr His Met Leu Asp Val Met Gln Asp His Phe Ser 
            180                 185                 190         


Arg Ala Ser Ser Ile Ile Asp Glu Leu Phe Gln Asp Arg Phe Phe Thr 
        195                 200                 205             


Arg Glu Pro Gln Asp Thr Tyr His Tyr Leu Pro Phe Ser Leu Pro His 
    210                 215                 220                 


Arg Arg Pro His Phe Phe Phe Pro Lys Ser Arg Ile Val Arg Ser Leu 
225                 230                 235                 240 


Met Pro Phe Ser Pro Tyr Glu Pro Leu Asn Phe His Ala Met Phe Gln 
                245                 250                 255     


Pro Phe Leu Glu Met Ile His Glu Ala Gln Gln Ala Met Asp Ile His 
            260                 265                 270         


Phe His Ser Pro Ala Phe Gln His Pro Pro Thr Glu Phe Ile Arg Glu 
        275                 280                 285             


Gly Asp Asp Asp Arg Thr Val Cys Arg 
    290                 295         


<210>  3066
<211>  32
<212>  PRT
<213>  Homo Sapiens

<400>  3066

Met Met Lys Thr Leu Leu Leu Phe Val Gly Leu Leu Leu Thr Trp Glu 
1               5                   10                  15      


Ser Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp Asn Glu Leu Gln 
            20                  25                  30          


<210>  3067
<211>  82
<212>  PRT
<213>  Homo Sapiens

<400>  3067

Met Met Lys Thr Leu Leu Leu Phe Val Gly Leu Leu Leu Thr Trp Glu 
1               5                   10                  15      


Ser Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp Asn Glu Leu Gln 
            20                  25                  30          


Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn 
        35                  40                  45              


Ala Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile Glu Lys Thr Asn 
    50                  55                  60                  


Glu Glu Arg Lys Thr Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys 
65                  70                  75                  80  


Lys Glu 
        


<210>  3068
<211>  82
<212>  PRT
<213>  Homo Sapiens

<400>  3068

Met Met Lys Thr Leu Leu Leu Phe Val Gly Leu Leu Leu Thr Trp Glu 
1               5                   10                  15      


Ser Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp Asn Glu Leu Gln 
            20                  25                  30          


Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn 
        35                  40                  45              


Ala Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile Glu Lys Thr Asn 
    50                  55                  60                  


Glu Glu Arg Lys Thr Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys 
65                  70                  75                  80  


Lys Glu 
        


<210>  3069
<211>  129
<212>  PRT
<213>  Homo Sapiens

<400>  3069

Met Met Lys Thr Leu Leu Leu Phe Val Gly Leu Leu Leu Thr Trp Glu 
1               5                   10                  15      


Ser Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp Asn Glu Leu Gln 
            20                  25                  30          


Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn 
        35                  40                  45              


Ala Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile Glu Lys Thr Asn 
    50                  55                  60                  


Glu Glu Arg Lys Thr Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys 
65                  70                  75                  80  


Lys Glu Asp Ala Leu Asn Glu Thr Arg Glu Ser Glu Thr Lys Leu Lys 
                85                  90                  95      


Glu Leu Pro Gly Val Cys Asn Glu Thr Met Met Ala Leu Trp Glu Glu 
            100                 105                 110         


Cys Lys Pro Cys Leu Lys Gln Thr Cys Met Lys Phe Tyr Ala Arg Val 
        115                 120                 125             


Cys 
    


<210>  3070
<211>  136
<212>  PRT
<213>  Homo Sapiens

<400>  3070

Met Met Lys Thr Leu Leu Leu Phe Val Gly Leu Leu Leu Thr Trp Glu 
1               5                   10                  15      


Ser Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp Asn Glu Leu Gln 
            20                  25                  30          


Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn 
        35                  40                  45              


Ala Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile Glu Lys Thr Asn 
    50                  55                  60                  


Glu Glu Arg Lys Thr Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys 
65                  70                  75                  80  


Lys Glu Asp Ala Leu Asn Glu Thr Arg Glu Ser Glu Thr Lys Leu Lys 
                85                  90                  95      


Glu Leu Pro Gly Val Cys Asn Glu Thr Met Met Ala Leu Trp Glu Glu 
            100                 105                 110         


Cys Lys Pro Cys Leu Lys Gln Thr Cys Met Lys Phe Tyr Ala Arg Val 
        115                 120                 125             


Cys Arg Ser Gly Ser Gly Leu Val 
    130                 135     


<210>  3071
<211>  139
<212>  PRT
<213>  Homo Sapiens

<400>  3071

Met Met Lys Thr Leu Leu Leu Phe Val Gly Leu Leu Leu Thr Trp Glu 
1               5                   10                  15      


Ser Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp Asn Glu Leu Gln 
            20                  25                  30          


Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn 
        35                  40                  45              


Ala Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile Glu Lys Thr Asn 
    50                  55                  60                  


Glu Glu Arg Lys Thr Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys 
65                  70                  75                  80  


Lys Glu Asp Ala Leu Asn Glu Thr Arg Glu Ser Glu Thr Lys Leu Lys 
                85                  90                  95      


Glu Leu Pro Gly Val Cys Asn Glu Thr Met Met Ala Leu Trp Glu Glu 
            100                 105                 110         


Cys Lys Pro Cys Leu Lys Gln Thr Cys Met Lys Phe Tyr Ala Arg Val 
        115                 120                 125             


Cys Arg Ser Gly Ser Gly Leu Val Gly Arg Gln 
    130                 135                 


<210>  3072
<211>  204
<212>  PRT
<213>  Homo Sapiens

<400>  3072

Met Met Lys Thr Leu Leu Leu Phe Val Gly Leu Leu Leu Thr Trp Glu 
1               5                   10                  15      


Ser Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp Asn Glu Leu Gln 
            20                  25                  30          


Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn 
        35                  40                  45              


Ala Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile Glu Lys Thr Asn 
    50                  55                  60                  


Glu Glu Arg Lys Thr Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys 
65                  70                  75                  80  


Lys Glu Asp Ala Leu Asn Glu Thr Arg Glu Ser Glu Thr Lys Leu Lys 
                85                  90                  95      


Glu Leu Pro Gly Val Cys Asn Glu Thr Met Met Ala Leu Trp Glu Glu 
            100                 105                 110         


Cys Lys Pro Cys Leu Lys Gln Thr Cys Met Lys Phe Tyr Ala Arg Val 
        115                 120                 125             


Cys Arg Ser Gly Ser Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu 
    130                 135                 140                 


Asn Gln Ser Ser Pro Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp 
145                 150                 155                 160 


Ser Leu Leu Glu Asn Asp Arg Gln Gln Thr His Met Leu Asp Val Met 
                165                 170                 175     


Gln Asp His Phe Ser Arg Ala Ser Ser Ile Ile Asp Glu Leu Phe Gln 
            180                 185                 190         


Asp Arg Phe Phe Thr Arg Glu Pro Gln Asp Thr Tyr 
        195                 200                 


<210>  3073
<211>  449
<212>  PRT
<213>  Homo Sapiens

<400>  3073

Met Met Lys Thr Leu Leu Leu Phe Val Gly Leu Leu Leu Thr Trp Glu 
1               5                   10                  15      


Ser Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp Asn Glu Leu Gln 
            20                  25                  30          


Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn 
        35                  40                  45              


Ala Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile Glu Lys Thr Asn 
    50                  55                  60                  


Glu Glu Arg Lys Thr Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys 
65                  70                  75                  80  


Lys Glu Asp Ala Leu Asn Glu Thr Arg Glu Ser Glu Thr Lys Leu Lys 
                85                  90                  95      


Glu Leu Pro Gly Val Cys Asn Glu Thr Met Met Ala Leu Trp Glu Glu 
            100                 105                 110         


Cys Lys Pro Cys Leu Lys Gln Thr Cys Met Lys Phe Tyr Ala Arg Val 
        115                 120                 125             


Cys Arg Ser Gly Ser Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu 
    130                 135                 140                 


Asn Gln Ser Ser Pro Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp 
145                 150                 155                 160 


Ser Leu Leu Glu Asn Asp Arg Gln Gln Thr His Met Leu Asp Val Met 
                165                 170                 175     


Gln Asp His Phe Ser Arg Ala Ser Ser Ile Ile Asp Glu Leu Phe Gln 
            180                 185                 190         


Asp Arg Phe Phe Thr Arg Glu Pro Gln Asp Thr Tyr His Tyr Leu Pro 
        195                 200                 205             


Phe Ser Leu Pro His Arg Arg Pro His Phe Phe Phe Pro Lys Ser Arg 
    210                 215                 220                 


Ile Val Arg Ser Leu Met Pro Phe Ser Pro Tyr Glu Pro Leu Asn Phe 
225                 230                 235                 240 


His Ala Met Phe Gln Pro Phe Leu Glu Met Ile His Glu Ala Gln Gln 
                245                 250                 255     


Ala Met Asp Ile His Phe His Ser Pro Ala Phe Gln His Pro Pro Thr 
            260                 265                 270         


Glu Phe Ile Arg Glu Gly Asp Asp Asp Arg Thr Val Cys Arg Glu Ile 
        275                 280                 285             


Arg His Asn Ser Thr Gly Cys Leu Arg Met Lys Asp Gln Cys Asp Lys 
    290                 295                 300                 


Cys Arg Glu Ile Leu Ser Val Asp Cys Ser Thr Asn Asn Pro Ser Gln 
305                 310                 315                 320 


Ala Lys Leu Arg Arg Glu Leu Asp Glu Ser Leu Gln Val Ala Glu Arg 
                325                 330                 335     


Leu Thr Arg Lys Tyr Asn Glu Leu Leu Lys Ser Tyr Gln Trp Lys Met 
            340                 345                 350         


Leu Asn Thr Ser Ser Leu Leu Glu Gln Leu Asn Glu Gln Phe Asn Trp 
        355                 360                 365             


Val Ser Arg Leu Ala Asn Leu Thr Gln Gly Glu Asp Gln Tyr Tyr Leu 
    370                 375                 380                 


Arg Val Thr Thr Val Ala Ser His Thr Ser Asp Ser Asp Val Pro Ser 
385                 390                 395                 400 


Gly Val Thr Glu Val Val Val Lys Leu Phe Asp Ser Asp Pro Ile Thr 
                405                 410                 415     


Val Thr Val Pro Val Glu Val Ser Arg Lys Asn Pro Lys Phe Met Glu 
            420                 425                 430         


Thr Val Ala Glu Lys Ala Leu Gln Glu Tyr Arg Lys Lys His Arg Glu 
        435                 440                 445             


Glu 
    


<210>  3074
<211>  449
<212>  PRT
<213>  Homo Sapiens

<400>  3074

Met Met Lys Thr Leu Leu Leu Phe Val Gly Leu Leu Leu Thr Trp Glu 
1               5                   10                  15      


Ser Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp Asn Glu Leu Gln 
            20                  25                  30          


Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn 
        35                  40                  45              


Ala Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile Glu Lys Thr Asn 
    50                  55                  60                  


Glu Glu Arg Lys Thr Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys 
65                  70                  75                  80  


Lys Glu Asp Ala Leu Asn Glu Thr Arg Glu Ser Glu Thr Lys Leu Lys 
                85                  90                  95      


Glu Leu Pro Gly Val Cys Asn Glu Thr Met Met Ala Leu Trp Glu Glu 
            100                 105                 110         


Cys Lys Pro Cys Leu Lys Gln Thr Cys Met Lys Phe Tyr Ala Arg Val 
        115                 120                 125             


Cys Arg Ser Gly Ser Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu 
    130                 135                 140                 


Asn Gln Ser Ser Pro Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp 
145                 150                 155                 160 


Ser Leu Leu Glu Asn Asp Arg Gln Gln Thr His Met Leu Asp Val Met 
                165                 170                 175     


Gln Asp His Phe Ser Arg Ala Ser Ser Ile Ile Asp Glu Leu Phe Gln 
            180                 185                 190         


Asp Arg Phe Phe Thr Arg Glu Pro Gln Asp Thr Tyr His Tyr Leu Pro 
        195                 200                 205             


Phe Ser Leu Pro His Arg Arg Pro His Phe Phe Phe Pro Lys Ser Arg 
    210                 215                 220                 


Ile Val Arg Ser Leu Met Pro Phe Ser Pro Tyr Glu Pro Leu Asn Phe 
225                 230                 235                 240 


His Ala Met Phe Gln Pro Phe Leu Glu Met Ile His Glu Ala Gln Gln 
                245                 250                 255     


Ala Met Asp Ile His Phe His Ser Pro Ala Phe Gln His Pro Pro Thr 
            260                 265                 270         


Glu Phe Ile Arg Glu Gly Asp Asp Asp Arg Thr Val Cys Arg Glu Ile 
        275                 280                 285             


Arg His Asn Ser Thr Gly Cys Leu Arg Met Lys Asp Gln Cys Asp Lys 
    290                 295                 300                 


Cys Arg Glu Ile Leu Ser Val Asp Cys Ser Thr Asn Asn Pro Ser Gln 
305                 310                 315                 320 


Ala Lys Leu Arg Arg Glu Leu Asp Glu Ser Leu Gln Val Ala Glu Arg 
                325                 330                 335     


Leu Thr Arg Lys Tyr Asn Glu Leu Leu Lys Ser Tyr Gln Trp Lys Met 
            340                 345                 350         


Leu Asn Thr Ser Ser Leu Leu Glu Gln Leu Asn Glu Gln Phe Asn Trp 
        355                 360                 365             


Val Ser Arg Leu Ala Asn Leu Thr Gln Gly Glu Asp Gln Tyr Tyr Leu 
    370                 375                 380                 


Arg Val Thr Thr Val Ala Ser His Thr Ser Asp Ser Asp Val Pro Ser 
385                 390                 395                 400 


Gly Val Thr Glu Val Val Val Lys Leu Phe Asp Ser Asp Pro Ile Thr 
                405                 410                 415     


Val Thr Val Pro Val Glu Val Ser Arg Lys Asn Pro Lys Phe Met Glu 
            420                 425                 430         


Thr Val Ala Glu Lys Ala Leu Gln Glu Tyr Arg Lys Lys His Arg Glu 
        435                 440                 445             


Glu 
    


<210>  3075
<211>  449
<212>  PRT
<213>  Homo Sapiens

<400>  3075

Met Met Lys Thr Leu Leu Leu Phe Val Gly Leu Leu Leu Thr Trp Glu 
1               5                   10                  15      


Ser Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp Asn Glu Leu Gln 
            20                  25                  30          


Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn 
        35                  40                  45              


Ala Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile Glu Lys Thr Asn 
    50                  55                  60                  


Glu Glu Arg Lys Thr Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys 
65                  70                  75                  80  


Lys Glu Asp Ala Leu Asn Glu Thr Arg Glu Ser Glu Thr Lys Leu Lys 
                85                  90                  95      


Glu Leu Pro Gly Val Cys Asn Glu Thr Met Met Ala Leu Trp Glu Glu 
            100                 105                 110         


Cys Lys Pro Cys Leu Lys Gln Thr Cys Met Lys Phe Tyr Ala Arg Val 
        115                 120                 125             


Cys Arg Ser Gly Ser Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu 
    130                 135                 140                 


Asn Gln Ser Ser Pro Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp 
145                 150                 155                 160 


Ser Leu Leu Glu Asn Asp Arg Gln Gln Thr His Met Leu Asp Val Met 
                165                 170                 175     


Gln Asp His Phe Ser Arg Ala Ser Ser Ile Ile Asp Glu Leu Phe Gln 
            180                 185                 190         


Asp Arg Phe Phe Thr Arg Glu Pro Gln Asp Thr Tyr His Tyr Leu Pro 
        195                 200                 205             


Phe Ser Leu Pro His Arg Arg Pro His Phe Phe Phe Pro Lys Ser Arg 
    210                 215                 220                 


Ile Val Arg Ser Leu Met Pro Phe Ser Pro Tyr Glu Pro Leu Asn Phe 
225                 230                 235                 240 


His Ala Met Phe Gln Pro Phe Leu Glu Met Ile His Glu Ala Gln Gln 
                245                 250                 255     


Ala Met Asp Ile His Phe His Ser Pro Ala Phe Gln His Pro Pro Thr 
            260                 265                 270         


Glu Phe Ile Arg Glu Gly Asp Asp Asp Arg Thr Val Cys Arg Glu Ile 
        275                 280                 285             


Arg His Asn Ser Thr Gly Cys Leu Arg Met Lys Asp Gln Cys Asp Lys 
    290                 295                 300                 


Cys Arg Glu Ile Leu Ser Val Asp Cys Ser Thr Asn Asn Pro Ser Gln 
305                 310                 315                 320 


Ala Lys Leu Arg Arg Glu Leu Asp Glu Ser Leu Gln Val Ala Glu Arg 
                325                 330                 335     


Leu Thr Arg Lys Tyr Asn Glu Leu Leu Lys Ser Tyr Gln Trp Lys Met 
            340                 345                 350         


Leu Asn Thr Ser Ser Leu Leu Glu Gln Leu Asn Glu Gln Phe Asn Trp 
        355                 360                 365             


Val Ser Arg Leu Ala Asn Leu Thr Gln Gly Glu Asp Gln Tyr Tyr Leu 
    370                 375                 380                 


Arg Val Thr Thr Val Ala Ser His Thr Ser Asp Ser Asp Val Pro Ser 
385                 390                 395                 400 


Gly Val Thr Glu Val Val Val Lys Leu Phe Asp Ser Asp Pro Ile Thr 
                405                 410                 415     


Val Thr Val Pro Val Glu Val Ser Arg Lys Asn Pro Lys Phe Met Glu 
            420                 425                 430         


Thr Val Ala Glu Lys Ala Leu Gln Glu Tyr Arg Lys Lys His Arg Glu 
        435                 440                 445             


Glu 
    


<210>  3076
<211>  271
<212>  PRT
<213>  Homo Sapiens

<400>  3076

Met Met Lys Thr Leu Leu Leu Phe Val Gly Leu Leu Leu Thr Trp Glu 
1               5                   10                  15      


Ser Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp Asn Glu Leu Gln 
            20                  25                  30          


Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn 
        35                  40                  45              


Ala Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile Glu Lys Thr Asn 
    50                  55                  60                  


Glu Glu Arg Lys Thr Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys 
65                  70                  75                  80  


Lys Glu Asp Ala Leu Asn Glu Thr Arg Glu Ser Glu Thr Lys Leu Lys 
                85                  90                  95      


Glu Leu Pro Gly Val Cys Asn Glu Thr Met Met Ala Leu Trp Glu Glu 
            100                 105                 110         


Cys Lys Pro Cys Leu Lys Gln Thr Cys Met Lys Phe Tyr Ala Arg Val 
        115                 120                 125             


Cys Arg Ser Gly Ser Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu 
    130                 135                 140                 


Asn Gln Ser Ser Pro Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp 
145                 150                 155                 160 


Ser Leu Leu Glu Asn Asp Arg Gln Gln Thr His Met Leu Asp Val Met 
                165                 170                 175     


Gln Asp His Phe Ser Arg Ala Ser Ser Ile Ile Asp Glu Leu Phe Gln 
            180                 185                 190         


Asp Ser Leu Met Pro Phe Ser Pro Tyr Glu Pro Leu Asn Phe His Ala 
        195                 200                 205             


Met Phe Gln Pro Phe Leu Glu Met Ile His Glu Ala Gln Gln Ala Met 
    210                 215                 220                 


Asp Ile His Phe His Ser Pro Ala Phe Gln His Pro Pro Thr Glu Phe 
225                 230                 235                 240 


Ile Arg Glu Gly Asp Asp Asp Arg Thr Val Cys Arg Glu Ile Arg His 
                245                 250                 255     


Asn Ser Thr Gly Cys Leu Arg Met Lys Asp Gln Cys Asp Lys Cys 
            260                 265                 270     


<210>  3077
<211>  140
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3077

Xaa Ala Asp Cys Ser Thr Asn Asn Pro Ser Gln Ala Lys Leu Arg Arg 
1               5                   10                  15      


Glu Leu Asp Glu Ser Leu Gln Val Ala Glu Arg Leu Thr Arg Lys Tyr 
            20                  25                  30          


Asn Glu Leu Leu Lys Ser Tyr Gln Trp Lys Met Leu Asn Thr Ser Ser 
        35                  40                  45              


Leu Leu Glu Gln Leu Asn Glu Gln Phe Asn Trp Val Ser Arg Leu Ala 
    50                  55                  60                  


Asn Leu Thr Gln Gly Glu Asp Gln Tyr Tyr Leu Arg Val Thr Thr Val 
65                  70                  75                  80  


Ala Ser His Thr Ser Asp Ser Asp Val Pro Ser Gly Val Thr Glu Val 
                85                  90                  95      


Val Val Lys Leu Phe Asp Ser Asp Pro Ile Thr Val Thr Val Pro Val 
            100                 105                 110         


Glu Val Ser Arg Lys Asn Pro Lys Phe Met Glu Thr Val Ala Glu Lys 
        115                 120                 125             


Ala Leu Gln Glu Tyr Arg Lys Lys His Arg Glu Glu 
    130                 135                 140 


<210>  3078
<211>  284
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3078

Xaa Gln Leu Glu Glu Phe Leu Asn Gln Ser Ser Pro Phe Tyr Phe Trp 
1               5                   10                  15      


Met Asn Gly Asp Arg Ile Asp Ser Leu Leu Glu Asn Asp Arg Gln Gln 
            20                  25                  30          


Thr His Met Leu Asp Val Met Gln Asp His Phe Ser Arg Ala Ser Ser 
        35                  40                  45              


Ile Ile Asp Glu Leu Phe Gln Asp Arg Phe Phe Thr Arg Glu Pro Gln 
    50                  55                  60                  


Asp Thr Tyr His Tyr Leu Pro Phe Ser Leu Pro His Arg Arg Pro His 
65                  70                  75                  80  


Phe Phe Phe Pro Lys Ser Arg Ile Val Arg Ser Leu Met Pro Phe Ser 
                85                  90                  95      


Pro Tyr Glu Pro Leu Asn Phe His Ala Met Phe Gln Pro Phe Leu Glu 
            100                 105                 110         


Met Ile His Glu Ala Gln Gln Ala Met Asp Ile His Phe His Ser Pro 
        115                 120                 125             


Ala Phe Gln His Pro Pro Thr Glu Phe Ile Arg Glu Gly Asp Asp Asp 
    130                 135                 140                 


Arg Thr Val Cys Arg Glu Ile Arg His Asn Ser Thr Gly Cys Leu Arg 
145                 150                 155                 160 


Met Lys Asp Gln Cys Asp Lys Cys Arg Glu Ile Leu Ser Val Asp Cys 
                165                 170                 175     


Ser Thr Asn Asn Pro Ser Gln Ala Lys Leu Arg Arg Glu Leu Asp Glu 
            180                 185                 190         


Ser Leu Gln Val Ala Glu Arg Leu Thr Arg Lys Tyr Asn Glu Leu Leu 
        195                 200                 205             


Lys Ser Tyr Gln Trp Lys Met Leu Asn Thr Ser Ser Leu Leu Glu Gln 
    210                 215                 220                 


Leu Asn Glu Gln Phe Asn Trp Val Ser Arg Leu Ala Asn Leu Thr Gln 
225                 230                 235                 240 


Gly Glu Asp Gln Tyr Tyr Leu Arg Val Thr Thr Val Ala Ser His Thr 
                245                 250                 255     


Ser Asp Ser Asp Val Pro Ser Gly Val Thr Glu Val Val Val Lys Leu 
            260                 265                 270         


Phe Asp Ser Asp Pro Ile Thr Val Thr Val Pro Val 
        275                 280                 


<210>  3079
<211>  466
<212>  PRT
<213>  Homo Sapiens

<400>  3079

Met Lys Pro Pro Leu Leu Val Phe Ile Val Cys Leu Leu Trp Leu Lys 
1               5                   10                  15      


Asp Ser His Cys Ala Pro Thr Trp Lys Asp Lys Thr Ala Ile Ser Glu 
            20                  25                  30          


Asn Leu Lys Ser Phe Ser Glu Val Gly Glu Ile Asp Ala Asp Glu Glu 
        35                  40                  45              


Val Lys Lys Ala Leu Thr Gly Ile Lys Gln Met Lys Ile Met Met Glu 
    50                  55                  60                  


Arg Lys Glu Lys Glu His Thr Asn Leu Met Ser Thr Leu Lys Lys Cys 
65                  70                  75                  80  


Arg Glu Glu Lys Gln Glu Ala Leu Lys Leu Leu Asn Glu Val Gln Glu 
                85                  90                  95      


His Leu Glu Glu Glu Glu Arg Leu Cys Arg Glu Ser Leu Ala Asp Ser 
            100                 105                 110         


Trp Gly Glu Cys Arg Ser Cys Leu Glu Asn Asn Cys Met Arg Ile Tyr 
        115                 120                 125             


Thr Thr Cys Gln Pro Ser Trp Ser Ser Val Lys Asn Lys Ile Glu Arg 
    130                 135                 140                 


Phe Phe Arg Lys Ile Tyr Gln Phe Leu Phe Pro Phe His Glu Asp Asn 
145                 150                 155                 160 


Glu Lys Asp Leu Pro Ile Ser Glu Lys Leu Ile Glu Glu Asp Ala Gln 
                165                 170                 175     


Leu Thr Gln Met Glu Asp Val Phe Ser Gln Leu Thr Val Asp Val Asn 
            180                 185                 190         


Ser Leu Phe Asn Arg Ser Phe Asn Val Phe Arg Gln Met Gln Gln Glu 
        195                 200                 205             


Phe Asp Gln Thr Phe Gln Ser His Phe Ile Ser Asp Thr Asp Leu Thr 
    210                 215                 220                 


Glu Pro Tyr Phe Phe Pro Ala Phe Ser Lys Glu Pro Met Thr Lys Ala 
225                 230                 235                 240 


Asp Leu Glu Gln Cys Trp Asp Ile Pro Asn Phe Phe Gln Leu Phe Cys 
                245                 250                 255     


Asn Phe Ser Val Ser Ile Tyr Glu Ser Val Ser Glu Thr Ile Thr Lys 
            260                 265                 270         


Met Leu Lys Ala Ile Glu Asp Leu Pro Lys Gln Asp Lys Ala Pro Asp 
        275                 280                 285             


His Gly Gly Leu Ile Ser Lys Met Leu Pro Gly Gln Asp Arg Gly Leu 
    290                 295                 300                 


Cys Gly Glu Leu Asp Gln Asn Leu Ser Arg Cys Phe Lys Phe His Glu 
305                 310                 315                 320 


Lys Cys Gln Lys Cys Gln Ala His Leu Ser Glu Asp Cys Pro Asp Val 
                325                 330                 335     


Pro Ala Leu His Thr Glu Leu Asp Glu Ala Ile Arg Leu Val Asn Val 
            340                 345                 350         


Ser Asn Gln Gln Tyr Gly Gln Ile Leu Gln Met Thr Arg Lys His Leu 
        355                 360                 365             


Glu Asp Thr Ala Tyr Leu Val Glu Lys Met Arg Gly Gln Phe Gly Trp 
    370                 375                 380                 


Val Ser Glu Leu Ala Asn Gln Ala Pro Glu Thr Glu Ile Ile Phe Asn 
385                 390                 395                 400 


Ser Ile Gln Val Val Pro Arg Ile His Glu Gly Asn Ile Ser Lys Gln 
                405                 410                 415     


Asp Glu Thr Met Met Thr Asp Leu Ser Ile Leu Pro Ser Ser Asn Phe 
            420                 425                 430         


Thr Leu Lys Ile Pro Leu Glu Glu Ser Ala Glu Ser Ser Asn Phe Ile 
        435                 440                 445             


Gly Tyr Val Val Ala Lys Ala Leu Gln His Phe Lys Glu His Phe Lys 
    450                 455                 460                 


Thr Trp 
465     


<210>  3080
<211>  466
<212>  PRT
<213>  Homo Sapiens

<400>  3080

Met Lys Pro Pro Leu Leu Val Phe Ile Val Cys Leu Leu Trp Leu Lys 
1               5                   10                  15      


Asp Ser His Cys Ala Pro Thr Trp Lys Asp Lys Thr Ala Ile Ser Glu 
            20                  25                  30          


Asn Leu Lys Ser Phe Ser Glu Val Gly Glu Ile Asp Ala Asp Glu Glu 
        35                  40                  45              


Val Lys Lys Ala Leu Thr Gly Ile Lys Gln Met Lys Ile Met Met Glu 
    50                  55                  60                  


Arg Lys Glu Lys Glu His Thr Asn Leu Met Ser Thr Leu Lys Lys Cys 
65                  70                  75                  80  


Arg Glu Glu Lys Gln Glu Ala Leu Lys Leu Leu Asn Glu Val Gln Glu 
                85                  90                  95      


His Leu Glu Glu Glu Glu Arg Leu Cys Arg Glu Ser Leu Ala Asp Ser 
            100                 105                 110         


Trp Gly Glu Cys Arg Ser Cys Leu Glu Asn Asn Cys Met Arg Ile Tyr 
        115                 120                 125             


Thr Thr Cys Gln Pro Ser Trp Ser Ser Val Lys Asn Lys Ile Glu Arg 
    130                 135                 140                 


Phe Phe Arg Lys Ile Tyr Gln Phe Leu Phe Pro Phe His Glu Asp Asn 
145                 150                 155                 160 


Glu Lys Asp Leu Pro Ile Ser Glu Lys Leu Ile Glu Glu Asp Ala Gln 
                165                 170                 175     


Leu Thr Gln Met Glu Asp Val Phe Ser Gln Leu Thr Val Asp Val Asn 
            180                 185                 190         


Ser Leu Phe Asn Arg Ser Phe Asn Val Phe Arg Gln Met Gln Gln Glu 
        195                 200                 205             


Phe Asp Gln Thr Phe Gln Ser His Phe Ile Ser Asp Thr Asp Leu Thr 
    210                 215                 220                 


Glu Pro Tyr Phe Phe Pro Ala Phe Ser Lys Glu Pro Met Thr Lys Ala 
225                 230                 235                 240 


Asp Leu Glu Gln Cys Trp Asp Ile Pro Asn Phe Phe Gln Leu Phe Cys 
                245                 250                 255     


Asn Phe Ser Val Ser Ile Tyr Glu Ser Val Ser Glu Thr Ile Thr Lys 
            260                 265                 270         


Met Leu Lys Ala Ile Glu Asp Leu Pro Lys Gln Asp Lys Ala Pro Asp 
        275                 280                 285             


His Gly Gly Leu Ile Ser Lys Met Leu Pro Gly Gln Asp Arg Gly Leu 
    290                 295                 300                 


Cys Gly Glu Leu Asp Gln Asn Leu Ser Arg Cys Phe Lys Phe His Glu 
305                 310                 315                 320 


Lys Cys Gln Lys Cys Gln Ala His Leu Ser Glu Asp Cys Pro Asp Val 
                325                 330                 335     


Pro Ala Leu His Thr Glu Leu Asp Glu Ala Ile Arg Leu Val Asn Val 
            340                 345                 350         


Ser Asn Gln Gln Tyr Gly Gln Ile Leu Gln Met Thr Arg Lys His Leu 
        355                 360                 365             


Glu Asp Thr Ala Tyr Leu Val Glu Lys Met Arg Gly Gln Phe Gly Trp 
    370                 375                 380                 


Val Ser Glu Leu Ala Asn Gln Ala Pro Glu Thr Glu Ile Ile Phe Asn 
385                 390                 395                 400 


Ser Ile Gln Val Val Pro Arg Ile His Glu Gly Asn Ile Ser Lys Gln 
                405                 410                 415     


Asp Glu Thr Met Met Thr Asp Leu Ser Ile Leu Pro Ser Ser Asn Phe 
            420                 425                 430         


Thr Leu Lys Ile Pro Leu Glu Glu Ser Ala Glu Ser Ser Asn Phe Ile 
        435                 440                 445             


Gly Tyr Val Val Ala Lys Ala Leu Gln His Phe Lys Glu His Phe Lys 
    450                 455                 460                 


Thr Trp 
465     


<210>  3081
<211>  466
<212>  PRT
<213>  Homo Sapiens

<400>  3081

Met Lys Pro Pro Leu Leu Val Phe Ile Val Cys Leu Leu Trp Leu Lys 
1               5                   10                  15      


Asp Ser His Cys Ala Pro Thr Trp Lys Asp Lys Thr Ala Ile Ser Glu 
            20                  25                  30          


Asn Leu Lys Ser Phe Ser Glu Val Gly Glu Ile Asp Ala Asp Glu Glu 
        35                  40                  45              


Val Lys Lys Ala Leu Thr Gly Ile Lys Gln Met Lys Ile Met Met Glu 
    50                  55                  60                  


Arg Lys Glu Lys Glu His Thr Asn Leu Met Ser Thr Leu Lys Lys Cys 
65                  70                  75                  80  


Arg Glu Glu Lys Gln Glu Ala Leu Lys Leu Leu Asn Glu Val Gln Glu 
                85                  90                  95      


His Leu Glu Glu Glu Glu Arg Leu Cys Arg Glu Ser Leu Ala Asp Ser 
            100                 105                 110         


Trp Gly Glu Cys Arg Ser Cys Leu Glu Asn Asn Cys Met Arg Ile Tyr 
        115                 120                 125             


Thr Thr Cys Gln Pro Ser Trp Ser Ser Val Lys Asn Lys Ile Glu Arg 
    130                 135                 140                 


Phe Phe Arg Lys Ile Tyr Gln Phe Leu Phe Pro Phe His Glu Asp Asn 
145                 150                 155                 160 


Glu Lys Asp Leu Pro Ile Ser Glu Lys Leu Ile Glu Glu Asp Ala Gln 
                165                 170                 175     


Leu Thr Gln Met Glu Asp Val Phe Ser Gln Leu Thr Val Asp Val Asn 
            180                 185                 190         


Ser Leu Phe Asn Arg Ser Phe Asn Val Phe Arg Gln Met Gln Gln Glu 
        195                 200                 205             


Phe Asp Gln Thr Phe Gln Ser His Phe Ile Ser Asp Thr Asp Leu Thr 
    210                 215                 220                 


Glu Pro Tyr Phe Phe Pro Ala Phe Ser Lys Glu Pro Met Thr Lys Ala 
225                 230                 235                 240 


Asp Leu Glu Gln Cys Trp Asp Ile Pro Asn Phe Phe Gln Leu Phe Cys 
                245                 250                 255     


Asn Phe Ser Val Ser Ile Tyr Glu Ser Val Ser Glu Thr Ile Thr Lys 
            260                 265                 270         


Met Leu Lys Ala Ile Glu Asp Leu Pro Lys Gln Asp Lys Ala Pro Asp 
        275                 280                 285             


His Gly Gly Leu Ile Ser Lys Met Leu Pro Gly Gln Asp Arg Gly Leu 
    290                 295                 300                 


Cys Gly Glu Leu Asp Gln Asn Leu Ser Arg Cys Phe Lys Phe His Glu 
305                 310                 315                 320 


Lys Cys Gln Lys Cys Gln Ala His Leu Ser Glu Asp Cys Pro Asp Val 
                325                 330                 335     


Pro Ala Leu His Thr Glu Leu Asp Glu Ala Ile Arg Leu Val Asn Val 
            340                 345                 350         


Ser Asn Gln Gln Tyr Gly Gln Ile Leu Gln Met Thr Arg Lys His Leu 
        355                 360                 365             


Glu Asp Thr Ala Tyr Leu Val Glu Lys Met Arg Gly Gln Phe Gly Trp 
    370                 375                 380                 


Val Ser Glu Leu Ala Asn Gln Ala Pro Glu Thr Glu Ile Ile Phe Asn 
385                 390                 395                 400 


Ser Ile Gln Val Val Pro Arg Ile His Glu Gly Asn Ile Ser Lys Gln 
                405                 410                 415     


Asp Glu Thr Met Met Thr Asp Leu Ser Ile Leu Pro Ser Ser Asn Phe 
            420                 425                 430         


Thr Leu Lys Ile Pro Leu Glu Glu Ser Ala Glu Ser Ser Asn Phe Ile 
        435                 440                 445             


Gly Tyr Val Val Ala Lys Ala Leu Gln His Phe Lys Glu His Phe Lys 
    450                 455                 460                 


Thr Trp 
465     


<210>  3082
<211>  491
<212>  PRT
<213>  Homo Sapiens

<400>  3082

Met Asn Ser Met Glu Ala Ala Val Gly Thr Glu Val Pro Leu Leu Asp 
1               5                   10                  15      


Asn Leu Gln His Cys Asn Ser Gly Asn Met Lys Pro Pro Leu Leu Val 
            20                  25                  30          


Phe Ile Val Cys Leu Leu Trp Leu Lys Asp Ser His Cys Ala Pro Thr 
        35                  40                  45              


Trp Lys Asp Lys Thr Ala Ile Ser Glu Asn Leu Lys Ser Phe Ser Glu 
    50                  55                  60                  


Val Gly Glu Ile Asp Ala Asp Glu Glu Val Lys Lys Ala Leu Thr Gly 
65                  70                  75                  80  


Ile Lys Gln Met Lys Ile Met Met Glu Arg Lys Glu Lys Glu His Thr 
                85                  90                  95      


Asn Leu Met Ser Thr Leu Lys Lys Cys Arg Glu Glu Lys Gln Glu Ala 
            100                 105                 110         


Leu Lys Leu Leu Asn Glu Val Gln Glu His Leu Glu Glu Glu Glu Arg 
        115                 120                 125             


Leu Cys Arg Glu Ser Leu Ala Asp Ser Trp Gly Glu Cys Arg Ser Cys 
    130                 135                 140                 


Leu Glu Asn Asn Cys Met Arg Ile Tyr Thr Thr Cys Gln Pro Ser Trp 
145                 150                 155                 160 


Ser Ser Val Lys Asn Lys Ile Glu Arg Phe Phe Arg Lys Ile Tyr Gln 
                165                 170                 175     


Phe Leu Phe Pro Phe His Glu Asp Asn Glu Lys Asp Leu Pro Ile Ser 
            180                 185                 190         


Glu Lys Leu Ile Glu Glu Asp Ala Gln Leu Thr Gln Met Glu Asp Val 
        195                 200                 205             


Phe Ser Gln Leu Thr Val Asp Val Asn Ser Leu Phe Asn Arg Ser Phe 
    210                 215                 220                 


Asn Val Phe Arg Gln Met Gln Gln Glu Phe Asp Gln Thr Phe Gln Ser 
225                 230                 235                 240 


His Phe Ile Ser Asp Thr Asp Leu Thr Glu Pro Tyr Phe Phe Pro Ala 
                245                 250                 255     


Phe Ser Lys Glu Pro Met Thr Lys Ala Asp Leu Glu Gln Cys Trp Asp 
            260                 265                 270         


Ile Pro Asn Phe Phe Gln Leu Phe Cys Asn Phe Ser Val Ser Ile Tyr 
        275                 280                 285             


Glu Ser Val Ser Glu Thr Ile Thr Lys Met Leu Lys Ala Ile Glu Asp 
    290                 295                 300                 


Leu Pro Lys Gln Asp Lys Ala Pro Asp His Gly Gly Leu Ile Ser Lys 
305                 310                 315                 320 


Met Leu Pro Gly Gln Asp Arg Gly Leu Cys Gly Glu Leu Asp Gln Asn 
                325                 330                 335     


Leu Ser Arg Cys Phe Lys Phe His Glu Lys Cys Gln Lys Cys Gln Ala 
            340                 345                 350         


His Leu Ser Glu Asp Cys Pro Asp Val Pro Ala Leu His Thr Glu Leu 
        355                 360                 365             


Asp Glu Ala Ile Arg Leu Val Asn Val Ser Asn Gln Gln Tyr Gly Gln 
    370                 375                 380                 


Ile Leu Gln Met Thr Arg Lys His Leu Glu Asp Thr Ala Tyr Leu Val 
385                 390                 395                 400 


Glu Lys Met Arg Gly Gln Phe Gly Trp Val Ser Glu Leu Ala Asn Gln 
                405                 410                 415     


Ala Pro Glu Thr Glu Ile Ile Phe Asn Ser Ile Gln Val Val Pro Arg 
            420                 425                 430         


Ile His Glu Gly Asn Ile Ser Lys Gln Asp Glu Thr Met Met Thr Asp 
        435                 440                 445             


Leu Ser Ile Leu Pro Ser Ser Asn Phe Thr Leu Lys Ile Pro Leu Glu 
    450                 455                 460                 


Glu Ser Ala Glu Ser Ser Asn Phe Ile Gly Tyr Val Val Ala Lys Ala 
465                 470                 475                 480 


Leu Gln His Phe Lys Glu His Phe Lys Thr Trp 
                485                 490     


<210>  3083
<211>  518
<212>  PRT
<213>  Homo Sapiens

<400>  3083

Met Arg Thr Trp Asp Tyr Arg Trp Ser Leu Ala Leu Val Ala Gln Thr 
1               5                   10                  15      


Gly Val His Cys Cys Asn Leu Ser Ser Leu Gln Pro Leu Pro Pro Arg 
            20                  25                  30          


Phe Lys Arg Phe Ser Cys Leu Ser Leu Ser Ser Gly Trp Asp Tyr Ser 
        35                  40                  45              


Asn Ser Gly Asn Met Lys Pro Pro Leu Leu Val Phe Ile Val Cys Leu 
    50                  55                  60                  


Leu Trp Leu Lys Asp Ser His Cys Ala Pro Thr Trp Lys Asp Lys Thr 
65                  70                  75                  80  


Ala Ile Ser Glu Asn Leu Lys Ser Phe Ser Glu Val Gly Glu Ile Asp 
                85                  90                  95      


Ala Asp Glu Glu Val Lys Lys Ala Leu Thr Gly Ile Lys Gln Met Lys 
            100                 105                 110         


Ile Met Met Glu Arg Lys Glu Lys Glu His Thr Asn Leu Met Ser Thr 
        115                 120                 125             


Leu Lys Lys Cys Arg Glu Glu Lys Gln Glu Ala Leu Lys Leu Leu Asn 
    130                 135                 140                 


Glu Val Gln Glu His Leu Glu Glu Glu Glu Arg Leu Cys Arg Glu Ser 
145                 150                 155                 160 


Leu Ala Asp Ser Trp Gly Glu Cys Arg Ser Cys Leu Glu Asn Asn Cys 
                165                 170                 175     


Met Arg Ile Tyr Thr Thr Cys Gln Pro Ser Trp Ser Ser Val Lys Asn 
            180                 185                 190         


Lys Ile Glu Arg Phe Phe Arg Lys Ile Tyr Gln Phe Leu Phe Pro Phe 
        195                 200                 205             


His Glu Asp Asn Glu Lys Asp Leu Pro Ile Ser Glu Lys Leu Ile Glu 
    210                 215                 220                 


Glu Asp Ala Gln Leu Thr Gln Met Glu Asp Val Phe Ser Gln Leu Thr 
225                 230                 235                 240 


Val Asp Val Asn Ser Leu Phe Asn Arg Ser Phe Asn Val Phe Arg Gln 
                245                 250                 255     


Met Gln Gln Glu Phe Asp Gln Thr Phe Gln Ser His Phe Ile Ser Asp 
            260                 265                 270         


Thr Asp Leu Thr Glu Pro Tyr Phe Phe Pro Ala Phe Ser Lys Glu Pro 
        275                 280                 285             


Met Thr Lys Ala Asp Leu Glu Gln Cys Trp Asp Ile Pro Asn Phe Phe 
    290                 295                 300                 


Gln Leu Phe Cys Asn Phe Ser Val Ser Ile Tyr Glu Ser Val Ser Glu 
305                 310                 315                 320 


Thr Ile Thr Lys Met Leu Lys Ala Ile Glu Asp Leu Pro Lys Gln Asp 
                325                 330                 335     


Lys Ala Pro Asp His Gly Gly Leu Ile Ser Lys Met Leu Pro Gly Gln 
            340                 345                 350         


Asp Arg Gly Leu Cys Gly Glu Leu Asp Gln Asn Leu Ser Arg Cys Phe 
        355                 360                 365             


Lys Phe His Glu Lys Cys Gln Lys Cys Gln Ala His Leu Ser Glu Asp 
    370                 375                 380                 


Cys Pro Asp Val Pro Ala Leu His Thr Glu Leu Asp Glu Ala Ile Arg 
385                 390                 395                 400 


Leu Val Asn Val Ser Asn Gln Gln Tyr Gly Gln Ile Leu Gln Met Thr 
                405                 410                 415     


Arg Lys His Leu Glu Asp Thr Ala Tyr Leu Val Glu Lys Met Arg Gly 
            420                 425                 430         


Gln Phe Gly Trp Val Ser Glu Leu Ala Asn Gln Ala Pro Glu Thr Glu 
        435                 440                 445             


Ile Ile Phe Asn Ser Ile Gln Val Val Pro Arg Ile His Glu Gly Asn 
    450                 455                 460                 


Ile Ser Lys Gln Asp Glu Thr Met Met Thr Asp Leu Ser Ile Leu Pro 
465                 470                 475                 480 


Ser Ser Asn Phe Thr Leu Lys Ile Pro Leu Glu Glu Ser Ala Glu Ser 
                485                 490                 495     


Ser Asn Phe Ile Gly Tyr Val Val Ala Lys Ala Leu Gln His Phe Lys 
            500                 505                 510         


Glu His Phe Lys Thr Trp 
        515             


<210>  3084
<211>  518
<212>  PRT
<213>  Homo Sapiens

<400>  3084

Met Arg Thr Trp Asp Tyr Arg Trp Ser Leu Ala Leu Val Ala Gln Thr 
1               5                   10                  15      


Gly Val His Cys Cys Asn Leu Ser Ser Leu Gln Pro Leu Pro Pro Arg 
            20                  25                  30          


Phe Lys Arg Phe Ser Cys Leu Ser Leu Ser Ser Gly Trp Asp Tyr Ser 
        35                  40                  45              


Asn Ser Gly Asn Met Lys Pro Pro Leu Leu Val Phe Ile Val Cys Leu 
    50                  55                  60                  


Leu Trp Leu Lys Asp Ser His Cys Ala Pro Thr Trp Lys Asp Lys Thr 
65                  70                  75                  80  


Ala Ile Ser Glu Asn Leu Lys Ser Phe Ser Glu Val Gly Glu Ile Asp 
                85                  90                  95      


Ala Asp Glu Glu Val Lys Lys Ala Leu Thr Gly Ile Lys Gln Met Lys 
            100                 105                 110         


Ile Met Met Glu Arg Lys Glu Lys Glu His Thr Asn Leu Met Ser Thr 
        115                 120                 125             


Leu Lys Lys Cys Arg Glu Glu Lys Gln Glu Ala Leu Lys Leu Leu Asn 
    130                 135                 140                 


Glu Val Gln Glu His Leu Glu Glu Glu Glu Arg Leu Cys Arg Glu Ser 
145                 150                 155                 160 


Leu Ala Asp Ser Trp Gly Glu Cys Arg Ser Cys Leu Glu Asn Asn Cys 
                165                 170                 175     


Met Arg Ile Tyr Thr Thr Cys Gln Pro Ser Trp Ser Ser Val Lys Asn 
            180                 185                 190         


Lys Ile Glu Arg Phe Phe Arg Lys Ile Tyr Gln Phe Leu Phe Pro Phe 
        195                 200                 205             


His Glu Asp Asn Glu Lys Asp Leu Pro Ile Ser Glu Lys Leu Ile Glu 
    210                 215                 220                 


Glu Asp Ala Gln Leu Thr Gln Met Glu Asp Val Phe Ser Gln Leu Thr 
225                 230                 235                 240 


Val Asp Val Asn Ser Leu Phe Asn Arg Ser Phe Asn Val Phe Arg Gln 
                245                 250                 255     


Met Gln Gln Glu Phe Asp Gln Thr Phe Gln Ser His Phe Ile Ser Asp 
            260                 265                 270         


Thr Asp Leu Thr Glu Pro Tyr Phe Phe Pro Ala Phe Ser Lys Glu Pro 
        275                 280                 285             


Met Thr Lys Ala Asp Leu Glu Gln Cys Trp Asp Ile Pro Asn Phe Phe 
    290                 295                 300                 


Gln Leu Phe Cys Asn Phe Ser Val Ser Ile Tyr Glu Ser Val Ser Glu 
305                 310                 315                 320 


Thr Ile Thr Lys Met Leu Lys Ala Ile Glu Asp Leu Pro Lys Gln Asp 
                325                 330                 335     


Lys Ala Pro Asp His Gly Gly Leu Ile Ser Lys Met Leu Pro Gly Gln 
            340                 345                 350         


Asp Arg Gly Leu Cys Gly Glu Leu Asp Gln Asn Leu Ser Arg Cys Phe 
        355                 360                 365             


Lys Phe His Glu Lys Cys Gln Lys Cys Gln Ala His Leu Ser Glu Asp 
    370                 375                 380                 


Cys Pro Asp Val Pro Ala Leu His Thr Glu Leu Asp Glu Ala Ile Arg 
385                 390                 395                 400 


Leu Val Asn Val Ser Asn Gln Gln Tyr Gly Gln Ile Leu Gln Met Thr 
                405                 410                 415     


Arg Lys His Leu Glu Asp Thr Ala Tyr Leu Val Glu Lys Met Arg Gly 
            420                 425                 430         


Gln Phe Gly Trp Val Ser Glu Leu Ala Asn Gln Ala Pro Glu Thr Glu 
        435                 440                 445             


Ile Ile Phe Asn Ser Ile Gln Val Val Pro Arg Ile His Glu Gly Asn 
    450                 455                 460                 


Ile Ser Lys Gln Asp Glu Thr Met Met Thr Asp Leu Ser Ile Leu Pro 
465                 470                 475                 480 


Ser Ser Asn Phe Thr Leu Lys Ile Pro Leu Glu Glu Ser Ala Glu Ser 
                485                 490                 495     


Ser Asn Phe Ile Gly Tyr Val Val Ala Lys Ala Leu Gln His Phe Lys 
            500                 505                 510         


Glu His Phe Lys Thr Trp 
        515             


<210>  3085
<211>  82
<212>  PRT
<213>  Homo Sapiens

<400>  3085

Met Arg Thr Trp Asp Tyr Ser Asn Ser Gly Asn Met Lys Pro Pro Leu 
1               5                   10                  15      


Leu Val Phe Ile Val Cys Leu Leu Trp Leu Lys Asp Ser His Cys Ala 
            20                  25                  30          


Pro Thr Trp Lys Asp Lys Thr Ala Ile Ser Glu Asn Leu Lys Ser Phe 
        35                  40                  45              


Ser Glu Val Gly Glu Ile Asp Ala Asp Glu Glu Val Lys Lys Ala Leu 
    50                  55                  60                  


Thr Gly Ile Lys Gln Met Lys Ile Met Met Glu Arg Lys Glu Lys Glu 
65                  70                  75                  80  


His Thr 
        


<210>  3086
<211>  34
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3086

Xaa Gln Phe Gly Trp Val Ser Glu Leu Ala Asn Gln Ala Pro Glu Thr 
1               5                   10                  15      


Glu Ile Ile Phe Asn Ser Ile Gln Val Arg Arg Ser Asn Ala Ser Tyr 
            20                  25                  30          


Ile Gln 
        


<210>  3087
<211>  136
<212>  PRT
<213>  Homo Sapiens

<400>  3087

Met Leu Leu Lys Leu Lys Glu Lys Ala Ser Leu Thr Leu Ala Val Gly 
1               5                   10                  15      


Thr Leu Pro Phe Pro Ser Gln Phe Asn Phe Val Pro Pro Gly Arg Met 
            20                  25                  30          


Cys Arg Val Ala Gly Trp Gly Arg Thr Gly Val Leu Lys Pro Gly Ser 
        35                  40                  45              


Asp Thr Leu Gln Glu Val Lys Leu Arg Leu Met Asp Pro Gln Ala Cys 
    50                  55                  60                  


Ser His Phe Arg Asp Phe Asp His Asn Leu Gln Leu Cys Val Gly Asn 
65                  70                  75                  80  


Pro Arg Lys Thr Lys Ser Ala Phe Lys Gly Asp Ser Gly Gly Pro Leu 
                85                  90                  95      


Leu Cys Ala Gly Val Ala Gln Gly Ile Val Ser Tyr Gly Arg Ser Asp 
            100                 105                 110         


Ala Lys Pro Pro Ala Val Phe Thr Arg Ile Ser His Tyr Arg Pro Trp 
        115                 120                 125             


Ile Asn Gln Ile Leu Gln Ala Asn 
    130                 135     


<210>  3088
<211>  247
<212>  PRT
<213>  Homo Sapiens

<400>  3088

Met Leu Leu Leu Pro Leu Pro Leu Leu Leu Phe Leu Leu Cys Ser Arg 
1               5                   10                  15      


Ala Glu Ala Gly Glu Ile Ile Gly Gly Thr Glu Cys Lys Pro His Ser 
            20                  25                  30          


Arg Pro Tyr Met Ala Tyr Leu Glu Ile Val Thr Ser Asn Gly Pro Ser 
        35                  40                  45              


Lys Phe Cys Gly Gly Phe Leu Ile Arg Arg Asn Phe Val Leu Thr Ala 
    50                  55                  60                  


Ala His Cys Ala Gly Arg Ser Ile Thr Val Thr Leu Gly Ala His Asn 
65                  70                  75                  80  


Ile Thr Glu Glu Glu Asp Thr Trp Gln Lys Leu Glu Val Ile Lys Gln 
                85                  90                  95      


Phe Arg His Pro Lys Tyr Asn Thr Ser Thr Leu His His Asp Ile Met 
            100                 105                 110         


Leu Leu Lys Leu Lys Glu Lys Ala Ser Leu Thr Leu Ala Val Gly Thr 
        115                 120                 125             


Leu Pro Phe Pro Ser Gln Phe Asn Phe Val Pro Pro Gly Arg Met Cys 
    130                 135                 140                 


Arg Val Ala Gly Trp Gly Arg Thr Gly Val Leu Lys Pro Gly Ser Asp 
145                 150                 155                 160 


Thr Leu Gln Glu Val Lys Leu Arg Leu Met Asp Pro Gln Ala Cys Ser 
                165                 170                 175     


His Phe Arg Asp Phe Asp His Asn Leu Gln Leu Cys Val Gly Asn Pro 
            180                 185                 190         


Arg Lys Thr Lys Ser Ala Phe Lys Gly Asp Ser Gly Gly Pro Leu Leu 
        195                 200                 205             


Cys Ala Gly Val Ala Gln Gly Ile Val Ser Tyr Gly Arg Ser Asp Ala 
    210                 215                 220                 


Lys Pro Pro Ala Val Phe Thr Arg Ile Ser His Tyr Arg Pro Trp Ile 
225                 230                 235                 240 


Asn Gln Ile Leu Gln Ala Asn 
                245         


<210>  3089
<211>  179
<212>  PRT
<213>  Homo Sapiens

<400>  3089

Met Leu Ser Arg Cys Arg Ser Gly Leu Leu His Val Leu Gly Leu Ser 
1               5                   10                  15      


Phe Leu Leu Gln Thr Arg Arg Pro Ile Leu Leu Cys Ser Pro Arg Leu 
            20                  25                  30          


Met Lys Pro Leu Val Val Phe Val Leu Gly Gly Pro Gly Ala Gly Lys 
        35                  40                  45              


Gly Thr Gln Cys Ala Arg Ile Val Glu Glu Met Asp Gln Thr Met Ala 
    50                  55                  60                  


Ala Asn Ala Gln Lys Asn Lys Phe Leu Ile Asp Gly Phe Pro Arg Asn 
65                  70                  75                  80  


Gln Asp Asn Leu Gln Gly Trp Asn Lys Thr Met Asp Gly Lys Ala Asp 
                85                  90                  95      


Val Ser Phe Val Leu Phe Phe Asp Cys Asn Asn Glu Ile Cys Ile Glu 
            100                 105                 110         


Arg Cys Leu Glu Arg Gly Lys Ser Ser Gly Arg Ser Asp Asp Asn Arg 
        115                 120                 125             


Glu Ser Leu Glu Lys Arg Ile Gln Thr Tyr Leu Gln Ser Thr Lys Pro 
    130                 135                 140                 


Ile Ile Asp Leu Tyr Glu Glu Met Gly Lys Val Lys Lys Ile Asp Ala 
145                 150                 155                 160 


Ser Lys Ser Val Asp Glu Val Phe Asp Glu Val Val Gln Ile Phe Asp 
                165                 170                 175     


Lys Glu Gly 
            


<210>  3090
<211>  58
<212>  PRT
<213>  Homo Sapiens

<400>  3090

Met Leu Ser Arg Cys Arg Ser Gly Leu Leu His Val Leu Gly Leu Ser 
1               5                   10                  15      


Phe Leu Leu Gln Thr Arg Arg Pro Ile Leu Leu Cys Ser Pro Arg Leu 
            20                  25                  30          


Met Lys Pro Leu Val Val Phe Val Leu Gly Gly Pro Gly Ala Gly Lys 
        35                  40                  45              


Gly Thr Gln Cys Ala Arg Ile Val Glu Gly 
    50                  55              


<210>  3091
<211>  228
<212>  PRT
<213>  Homo Sapiens

<400>  3091

Met Leu Ser Arg Cys Arg Ser Gly Leu Leu His Val Leu Gly Leu Ser 
1               5                   10                  15      


Phe Leu Leu Gln Thr Arg Arg Pro Ile Leu Leu Cys Ser Pro Arg Leu 
            20                  25                  30          


Met Lys Pro Leu Val Val Phe Val Leu Gly Gly Pro Gly Ala Gly Lys 
        35                  40                  45              


Gly Thr Gln Cys Ala Arg Ile Val Glu Lys Tyr Gly Tyr Thr His Leu 
    50                  55                  60                  


Ser Ala Gly Glu Leu Leu Arg Asp Glu Arg Lys Asn Pro Asp Ser Gln 
65                  70                  75                  80  


Tyr Gly Glu Leu Ile Glu Lys Tyr Ile Lys Glu Gly Lys Ile Val Pro 
                85                  90                  95      


Val Glu Ile Thr Ile Ser Leu Leu Lys Arg Glu Met Asp Gln Thr Met 
            100                 105                 110         


Ala Ala Asn Ala Gln Lys Asn Lys Phe Leu Ile Asp Gly Phe Pro Arg 
        115                 120                 125             


Asn Gln Asp Asn Leu Gln Gly Trp Asn Lys Thr Met Asp Gly Lys Ala 
    130                 135                 140                 


Asp Val Ser Phe Val Leu Phe Phe Asp Cys Asn Asn Glu Ile Cys Ile 
145                 150                 155                 160 


Glu Arg Cys Leu Glu Arg Gly Lys Ser Ser Gly Arg Ser Asp Asp Asn 
                165                 170                 175     


Arg Glu Ser Leu Glu Lys Arg Ile Gln Thr Tyr Leu Gln Ser Thr Lys 
            180                 185                 190         


Pro Ile Ile Asp Leu Tyr Glu Glu Met Gly Lys Val Lys Lys Ile Asp 
        195                 200                 205             


Ala Ser Lys Ser Val Asp Glu Val Phe Asp Glu Val Val Gln Ile Phe 
    210                 215                 220                 


Asp Lys Glu Gly 
225             


<210>  3092
<211>  169
<212>  PRT
<213>  Homo Sapiens

<400>  3092

Met Leu Ser Arg Cys Arg Ser Gly Leu Leu His Val Leu Gly Leu Ser 
1               5                   10                  15      


Phe Leu Leu Gln Thr Arg Arg Pro Ile Leu Leu Cys Ser Pro Arg Leu 
            20                  25                  30          


Met Lys Pro Leu Val Val Phe Val Leu Gly Gly Pro Gly Ala Gly Lys 
        35                  40                  45              


Gly Thr Gln Cys Ala Arg Ile Val Glu Lys Tyr Gly Tyr Thr His Leu 
    50                  55                  60                  


Ser Ala Gly Glu Leu Leu Arg Asp Glu Arg Lys Asn Pro Asp Ser Gln 
65                  70                  75                  80  


Tyr Gly Glu Leu Ile Glu Lys Tyr Ile Lys Glu Gly Lys Ile Val Pro 
                85                  90                  95      


Val Glu Ile Thr Ile Ser Leu Leu Lys Arg Glu Met Asp Gln Thr Met 
            100                 105                 110         


Ala Ala Asn Ala Gln Lys Asn Lys Phe Leu Ile Asp Gly Phe Pro Arg 
        115                 120                 125             


Asn Gln Asp Asn Leu Gln Gly Trp Asn Lys Thr Met Asp Gly Lys Ala 
    130                 135                 140                 


Asp Val Ser Phe Val Leu Phe Phe Asp Cys Asn Asn Glu Asn Ser Asp 
145                 150                 155                 160 


Leu Pro Ser Val Asn Lys Ala Asn Tyr 
                165                 


<210>  3093
<211>  436
<212>  PRT
<213>  Homo Sapiens

<400>  3093

Met Pro Met Ser Ser Leu Pro Ala Ala Ile Leu Ser His Met Thr Ala 
1               5                   10                  15      


Ile Asn Asn Val Pro Pro Pro Pro Leu His Ser Ile Pro Asn Leu Lys 
            20                  25                  30          


Lys Ser Lys His Ile Asn Tyr Gly Gln Leu Asn Ala Leu Cys His Ile 
        35                  40                  45              


Arg Gly Gln His Ser Arg Ser Met Ser Asn Ile Leu Ser Ala His Asp 
    50                  55                  60                  


Thr Phe Met Lys Gln Tyr Pro Lys Val Phe Leu His Gln Lys Pro Arg 
65                  70                  75                  80  


Leu Pro Lys Leu Phe Lys Gln Glu Glu Gln Arg Glu Leu Asn Glu Gly 
                85                  90                  95      


Lys Glu Glu Ser Gln His Gln Gln Pro Asp Asp Ser Asn Asn Ile Ala 
            100                 105                 110         


Val His Val Gln Arg Ala His Gly Gly His Ile Leu Tyr Arg Pro Lys 
        115                 120                 125             


Arg Ala Thr Glu Lys Phe Glu Glu Phe Leu Ala Ile Leu Lys Lys Leu 
    130                 135                 140                 


Pro Ile His Arg Thr Pro Tyr Glu His Lys Thr Val Trp Lys Phe Leu 
145                 150                 155                 160 


Lys Thr Ile Pro Asp Leu Thr Phe Gln Leu Asn Asp Lys His Leu Lys 
                165                 170                 175     


Thr Leu Ser Lys Thr Val Phe Ser Glu Thr Trp Leu Lys Gly Ser Thr 
            180                 185                 190         


Val Val Ala Asn Asp Gly Phe Tyr Val Ile Leu Lys Gly Leu Ala Arg 
        195                 200                 205             


Pro Gln Thr Asn Val Tyr Lys Asn Leu Ile Glu Gly Ser Asp Ser Pro 
    210                 215                 220                 


Asp Ser Phe Ile Ser Gln Ser Phe His Ser Phe Ile Trp Ser Glu Glu 
225                 230                 235                 240 


Phe Lys Asn Ser Thr Leu Ala Glu Met Tyr Leu Pro Ser Tyr Asp Ser 
                245                 250                 255     


Met Leu Ser Lys Trp Ser Thr Phe Gly Thr Leu Glu Val Met Pro Gln 
            260                 265                 270         


Asn Glu Ser Glu Thr Gln Met Phe Ser Val Val Thr Glu Asp Asp Cys 
        275                 280                 285             


Glu Ile Leu Lys Ile Pro Ala Lys Gly Tyr Ala Lys Ile Lys Glu Glu 
    290                 295                 300                 


Lys Ile Lys Leu Glu Asn Met Gln Lys Leu Lys Leu Ile Arg Met Cys 
305                 310                 315                 320 


Pro Tyr Tyr Glu Glu Trp Pro Thr Leu Ser Ile Tyr Glu Leu Ile Ala 
                325                 330                 335     


Leu Leu Lys Trp Lys Lys Phe Pro Pro Gly His Val Ile Val Glu Ser 
            340                 345                 350         


Gly Asn Ile Ile Ser Phe Val Gly Tyr Ile Asn Ser Gly Cys Cys Asn 
        355                 360                 365             


Ile Tyr Arg Ser Ile Ile Gly Phe Val Lys Leu Arg Ser Asn Lys Val 
    370                 375                 380                 


Lys Arg Ser Gln Lys Leu Val Tyr Met Gly Lys Leu Lys Glu Lys Glu 
385                 390                 395                 400 


Ser Phe Gly Glu Ile Ser Val Leu Leu Gln Val Pro Phe Thr Cys Thr 
                405                 410                 415     


Ile Ile Thr Lys Lys Glu Val Glu Met Ala Ile Ile Glu Asp Lys Asp 
            420                 425                 430         


Leu Phe Val Ala 
        435     


<210>  3094
<211>  292
<212>  PRT
<213>  Homo Sapiens

<400>  3094

Pro Ile His Arg Thr Pro Tyr Glu His Lys Thr Val Trp Lys Phe Leu 
1               5                   10                  15      


Lys Thr Ile Pro Asp Leu Thr Phe Gln Leu Asn Asp Lys His Leu Lys 
            20                  25                  30          


Thr Leu Ser Lys Thr Val Phe Ser Glu Thr Trp Leu Lys Gly Ser Thr 
        35                  40                  45              


Val Val Ala Asn Asp Gly Phe Tyr Val Ile Leu Lys Gly Leu Ala Arg 
    50                  55                  60                  


Pro Gln Thr Asn Val Tyr Lys Asn Leu Ile Glu Gly Ser Asp Ser Pro 
65                  70                  75                  80  


Asp Ser Phe Ile Ser Gln Ser Phe His Ser Phe Ile Trp Ser Glu Glu 
                85                  90                  95      


Phe Lys Asn Ser Thr Leu Ala Glu Met Tyr Leu Pro Ser Tyr Asp Ser 
            100                 105                 110         


Met Leu Ser Lys Trp Ser Thr Phe Gly Thr Leu Glu Val Met Pro Gln 
        115                 120                 125             


Asn Glu Ser Glu Thr Gln Met Phe Ser Val Val Thr Glu Asp Asp Cys 
    130                 135                 140                 


Glu Ile Leu Lys Ile Pro Ala Lys Gly Tyr Ala Lys Ile Lys Glu Glu 
145                 150                 155                 160 


Lys Ile Lys Leu Glu Asn Met Gln Lys Leu Lys Leu Ile Arg Met Cys 
                165                 170                 175     


Pro Tyr Tyr Glu Glu Trp Pro Thr Leu Ser Ile Tyr Glu Leu Ile Ala 
            180                 185                 190         


Leu Leu Lys Trp Lys Lys Phe Pro Pro Gly His Val Ile Val Glu Ser 
        195                 200                 205             


Gly Asn Ile Ile Ser Phe Val Gly Tyr Ile Asn Ser Gly Cys Cys Asn 
    210                 215                 220                 


Ile Tyr Arg Ser Ile Ile Gly Phe Val Lys Leu Arg Ser Asn Lys Val 
225                 230                 235                 240 


Lys Arg Ser Gln Lys Leu Val Tyr Met Gly Lys Leu Lys Glu Lys Glu 
                245                 250                 255     


Ser Phe Gly Glu Ile Ser Val Leu Leu Gln Val Pro Phe Thr Cys Thr 
            260                 265                 270         


Ile Ile Thr Lys Lys Glu Val Glu Met Ala Ile Ile Glu Asp Lys Asp 
        275                 280                 285             


Leu Phe Asp Ala 
    290         


<210>  3095
<211>  161
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3095

Xaa Gly Cys Cys Asn Ile Tyr Arg Ser Ile Ile Gly Phe Val Lys Leu 
1               5                   10                  15      


Arg Ser Asn Lys Val Lys Arg Ser Gln Lys Leu Val Tyr Met Gly Lys 
            20                  25                  30          


Leu Lys Glu Lys Glu Ser Phe Gly Glu Ile Ser Val Leu Leu Gln Val 
        35                  40                  45              


Pro Phe Thr Cys Thr Ile Ile Thr Lys Lys Glu Val Glu Met Ala Ile 
    50                  55                  60                  


Ile Glu Asp Lys Asp Leu Phe Glu Leu Asp Pro Val Thr Lys Gln Leu 
65                  70                  75                  80  


Met Leu Gln Thr Ala Lys Pro Thr Phe Gly His Leu Thr Asp Glu Asp 
                85                  90                  95      


Val Lys Asn Glu Tyr Leu Lys Lys Glu Gln Gln Lys Glu Trp Lys Asp 
            100                 105                 110         


Phe Lys Ile Ala Ser Trp Thr Lys Glu Ile Thr Asp Phe Ile Cys Leu 
        115                 120                 125             


Tyr Glu Lys His Gln Asp Asn Phe Thr Leu Pro Lys Ile Ala His Leu 
    130                 135                 140                 


Glu Arg Ile Thr Lys Arg Ile Lys Asn Asn Ser Ile Leu Ile His Leu 
145                 150                 155                 160 


Glu 
    


<210>  3096
<211>  207
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3096

Xaa Asn Met Gln Lys Leu Lys Leu Ile Arg Met Cys Pro Tyr Tyr Glu 
1               5                   10                  15      


Glu Trp Pro Thr Leu Ser Ile Tyr Glu Leu Ile Ala Leu Leu Lys Trp 
            20                  25                  30          


Lys Lys Phe Pro Pro Gly His Val Ile Val Glu Ser Gly Asn Ile Ile 
        35                  40                  45              


Ser Phe Val Gly Tyr Ile Asn Ser Gly Cys Cys Asn Ile Tyr Arg Ser 
    50                  55                  60                  


Ile Ile Gly Phe Val Lys Leu Arg Ser Asn Lys Val Lys Arg Ser Gln 
65                  70                  75                  80  


Lys Leu Val Tyr Met Gly Lys Leu Lys Glu Lys Glu Ser Phe Gly Glu 
                85                  90                  95      


Ile Ser Val Leu Leu Gln Val Pro Phe Thr Cys Thr Ile Ile Thr Lys 
            100                 105                 110         


Lys Glu Val Glu Met Ala Ile Ile Glu Asp Lys Asp Leu Phe Glu Leu 
        115                 120                 125             


Asp Pro Val Thr Lys Gln Leu Met Leu Gln Thr Ala Lys Pro Thr Phe 
    130                 135                 140                 


Gly His Leu Thr Asp Glu Asp Val Lys Asn Glu Tyr Leu Lys Lys Glu 
145                 150                 155                 160 


Gln Gln Lys Glu Trp Lys Asp Phe Lys Asp Lys Thr Val Lys Asn Ser 
                165                 170                 175     


Leu Tyr Tyr Lys Gly Ile Ile Pro Gly Phe Gly Lys Trp Asp His Tyr 
            180                 185                 190         


Cys Thr Ser Ile Pro Arg Asn Leu Lys Asp Thr Leu Val Asn Tyr 
        195                 200                 205         


<210>  3097
<211>  507
<212>  PRT
<213>  Homo Sapiens

<400>  3097

Met Asp Pro Lys Leu Gly Arg Met Ala Ala Ser Leu Leu Ala Val Leu 
1               5                   10                  15      


Leu Leu Leu Leu Glu Arg Gly Met Phe Ser Ser Pro Ser Pro Pro Pro 
            20                  25                  30          


Ala Leu Leu Glu Lys Val Phe Gln Tyr Ile Asp Leu His Gln Asp Glu 
        35                  40                  45              


Phe Val Gln Thr Leu Lys Glu Trp Val Ala Ile Glu Ser Asp Ser Val 
    50                  55                  60                  


Gln Pro Val Pro Arg Phe Arg Gln Glu Leu Phe Arg Met Met Ala Val 
65                  70                  75                  80  


Ala Ala Asp Thr Leu Gln Arg Leu Gly Ala Arg Val Ala Ser Val Asp 
                85                  90                  95      


Met Gly Pro Gln Gln Leu Pro Asp Gly Gln Ser Leu Pro Ile Pro Pro 
            100                 105                 110         


Val Ile Leu Ala Glu Leu Gly Ser Asp Pro Thr Lys Gly Thr Val Cys 
        115                 120                 125             


Phe Tyr Gly His Leu Asp Val Gln Pro Ala Asp Arg Gly Asp Gly Trp 
    130                 135                 140                 


Leu Thr Asp Pro Tyr Val Leu Thr Glu Val Asp Gly Lys Leu Tyr Gly 
145                 150                 155                 160 


Arg Gly Ala Thr Asp Asn Lys Gly Pro Val Leu Ala Trp Ile Asn Ala 
                165                 170                 175     


Val Ser Ala Phe Arg Ala Leu Glu Gln Asp Leu Pro Val Asn Ile Lys 
            180                 185                 190         


Phe Ile Ile Glu Gly Met Glu Glu Ala Gly Ser Val Ala Leu Glu Glu 
        195                 200                 205             


Leu Val Glu Lys Glu Lys Asp Arg Phe Phe Ser Gly Val Asp Tyr Ile 
    210                 215                 220                 


Val Ile Ser Asp Asn Leu Trp Ile Ser Gln Arg Lys Pro Ala Ile Thr 
225                 230                 235                 240 


Tyr Gly Thr Arg Gly Asn Ser Tyr Phe Met Val Glu Val Lys Cys Arg 
                245                 250                 255     


Asp Gln Asp Phe His Ser Gly Thr Phe Gly Gly Ile Leu His Glu Pro 
            260                 265                 270         


Met Ala Asp Leu Val Ala Leu Leu Gly Ser Leu Val Asp Ser Ser Gly 
        275                 280                 285             


His Ile Leu Val Pro Gly Ile Tyr Asp Glu Val Val Pro Leu Thr Glu 
    290                 295                 300                 


Glu Glu Ile Asn Thr Tyr Lys Ala Ile His Leu Asp Leu Glu Glu Tyr 
305                 310                 315                 320 


Arg Asn Ser Ser Arg Val Glu Lys Phe Leu Phe Asp Thr Lys Glu Glu 
                325                 330                 335     


Ile Leu Met His Leu Trp Arg Tyr Pro Ser Leu Ser Ile His Gly Ile 
            340                 345                 350         


Glu Gly Ala Phe Asp Glu Pro Gly Thr Lys Thr Val Ile Pro Gly Arg 
        355                 360                 365             


Val Ile Gly Lys Phe Ser Ile Arg Leu Val Pro His Met Asn Val Ser 
    370                 375                 380                 


Ala Val Glu Lys Gln Val Thr Arg His Leu Glu Asp Val Phe Ser Lys 
385                 390                 395                 400 


Arg Asn Ser Ser Asn Lys Met Val Val Ser Met Thr Leu Gly Leu His 
                405                 410                 415     


Pro Trp Ile Ala Asn Ile Asp Asp Thr Gln Tyr Leu Ala Ala Lys Arg 
            420                 425                 430         


Ala Ile Arg Thr Val Phe Gly Thr Glu Pro Asp Met Ile Arg Asp Gly 
        435                 440                 445             


Ser Thr Ile Pro Ile Ala Lys Met Phe Gln Glu Ile Val His Lys Ser 
    450                 455                 460                 


Val Val Leu Ile Pro Leu Gly Ala Val Asp Asp Gly Glu His Ser Gln 
465                 470                 475                 480 


Asn Glu Lys Ile Asn Arg Trp Asn Tyr Ile Glu Gly Thr Lys Leu Phe 
                485                 490                 495     


Ala Ala Phe Phe Leu Glu Met Ala Gln Leu His 
            500                 505         


<210>  3098
<211>  464
<212>  PRT
<213>  Homo Sapiens

<400>  3098

Met Asp Pro Lys Leu Gly Arg Met Thr Leu Lys Glu Trp Val Ala Ile 
1               5                   10                  15      


Glu Ser Asp Ser Val Gln Pro Val Pro Arg Phe Arg Gln Glu Leu Phe 
            20                  25                  30          


Arg Met Met Ala Val Ala Ala Asp Thr Leu Gln Arg Leu Gly Ala Arg 
        35                  40                  45              


Val Ala Ser Val Asp Met Gly Pro Gln Gln Leu Pro Asp Gly Gln Ser 
    50                  55                  60                  


Leu Pro Ile Pro Pro Val Ile Leu Ala Glu Leu Gly Ser Asp Pro Thr 
65                  70                  75                  80  


Lys Gly Thr Val Cys Phe Tyr Gly His Leu Asp Val Gln Pro Ala Asp 
                85                  90                  95      


Arg Gly Asp Gly Trp Leu Thr Asp Pro Tyr Val Leu Thr Glu Val Asp 
            100                 105                 110         


Gly Lys Leu Tyr Gly Arg Gly Ala Thr Asp Asn Lys Gly Pro Val Leu 
        115                 120                 125             


Ala Trp Ile Asn Ala Val Ser Ala Phe Arg Ala Leu Glu Gln Asp Leu 
    130                 135                 140                 


Pro Val Asn Ile Lys Phe Ile Ile Glu Gly Met Glu Glu Ala Gly Ser 
145                 150                 155                 160 


Val Ala Leu Glu Glu Leu Val Glu Lys Glu Lys Asp Arg Phe Phe Ser 
                165                 170                 175     


Gly Val Asp Tyr Ile Val Ile Ser Asp Asn Leu Trp Ile Ser Gln Arg 
            180                 185                 190         


Lys Pro Ala Ile Thr Tyr Gly Thr Arg Gly Asn Ser Tyr Phe Met Val 
        195                 200                 205             


Glu Val Lys Cys Arg Asp Gln Asp Phe His Ser Gly Thr Phe Gly Gly 
    210                 215                 220                 


Ile Leu His Glu Pro Met Ala Asp Leu Val Ala Leu Leu Gly Ser Leu 
225                 230                 235                 240 


Val Asp Ser Ser Gly His Ile Leu Val Pro Gly Ile Tyr Asp Glu Val 
                245                 250                 255     


Val Pro Leu Thr Glu Glu Glu Ile Asn Thr Tyr Lys Ala Ile His Leu 
            260                 265                 270         


Asp Leu Glu Glu Tyr Arg Asn Ser Ser Arg Val Glu Lys Phe Leu Phe 
        275                 280                 285             


Asp Thr Lys Glu Glu Ile Leu Met His Leu Trp Arg Tyr Pro Ser Leu 
    290                 295                 300                 


Ser Ile His Gly Ile Glu Gly Ala Phe Asp Glu Pro Gly Thr Lys Thr 
305                 310                 315                 320 


Val Ile Pro Gly Arg Val Ile Gly Lys Phe Ser Ile Arg Leu Val Pro 
                325                 330                 335     


His Met Asn Val Ser Ala Val Glu Lys Gln Val Thr Arg His Leu Glu 
            340                 345                 350         


Asp Val Phe Ser Lys Arg Asn Ser Ser Asn Lys Met Val Val Ser Met 
        355                 360                 365             


Thr Leu Gly Leu His Pro Trp Ile Ala Asn Ile Asp Asp Thr Gln Tyr 
    370                 375                 380                 


Leu Ala Ala Lys Arg Ala Ile Arg Thr Val Phe Gly Thr Glu Pro Asp 
385                 390                 395                 400 


Met Ile Arg Asp Gly Ser Thr Ile Pro Ile Ala Lys Met Phe Gln Glu 
                405                 410                 415     


Ile Val His Lys Ser Val Val Leu Ile Pro Leu Gly Ala Val Asp Asp 
            420                 425                 430         


Gly Glu His Ser Gln Asn Glu Lys Ile Asn Arg Trp Asn Tyr Ile Glu 
        435                 440                 445             


Gly Thr Lys Leu Phe Ala Ala Phe Phe Leu Glu Met Ala Gln Leu His 
    450                 455                 460                 


<210>  3099
<211>  38
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3099

Xaa Ala Asp Arg Gly Asp Gly Trp Leu Thr Asp Pro Tyr Val Leu Thr 
1               5                   10                  15      


Glu Gly Asn Phe Met Asp Glu Glu Arg Pro Thr Thr Lys Ala Leu Ser 
            20                  25                  30          


Trp Leu Gly Ser Met Leu 
        35              


<210>  3100
<211>  61
<212>  PRT
<213>  Homo Sapiens

<400>  3100

Ile Leu Gln Lys Ile Leu Leu Asp Asp Thr Gly Leu Ala Tyr Ile Cys 
1               5                   10                  15      


Gln Thr Tyr Glu Arg Phe Ser His Val Ala Met Ile Leu Gly Lys Met 
            20                  25                  30          


Val Leu Gln Leu Ser Lys Glu Pro Ser Ala Arg Leu Leu Lys His Val 
        35                  40                  45              


Val Arg Cys Tyr Leu Arg Leu Ser Asp Asn Pro Arg Cys 
    50                  55                  60      


<210>  3101
<211>  41
<212>  PRT
<213>  Homo Sapiens

<400>  3101

Met His Ser Leu Ala Thr Ala Ala Asp Leu Ala Leu Leu Pro Arg Leu 
1               5                   10                  15      


Glu Cys Ser Gly Val Ile Leu Ala His Arg Asn Leu Asp Leu Leu Gly 
            20                  25                  30          


Ser Val Asp Ser Pro Thr Ser Ala Ser 
        35                  40      


<210>  3102
<211>  299
<212>  PRT
<213>  Homo Sapiens

<400>  3102

Met His Ser Leu Ala Thr Ala Ala Pro Val Pro Thr Thr Leu Ala Gln 
1               5                   10                  15      


Val Asp Arg Glu Lys Ile Tyr Gln Trp Ile Asn Glu Leu Ser Ser Pro 
            20                  25                  30          


Glu Thr Arg Glu Asn Ala Leu Leu Glu Leu Ser Lys Lys Arg Glu Ser 
        35                  40                  45              


Val Pro Asp Leu Ala Pro Met Leu Trp His Ser Phe Gly Thr Ile Ala 
    50                  55                  60                  


Ala Leu Leu Gln Glu Ile Val Asn Ile Tyr Pro Ser Ile Asn Pro Pro 
65                  70                  75                  80  


Thr Leu Thr Ala His Gln Ser Asn Arg Val Cys Asn Ala Leu Ala Leu 
                85                  90                  95      


Leu Gln Cys Val Ala Ser His Pro Glu Thr Arg Ser Ala Phe Leu Ala 
            100                 105                 110         


Ala His Ile Pro Leu Phe Leu Tyr Pro Phe Leu His Thr Val Ser Lys 
        115                 120                 125             


Thr Arg Pro Phe Glu Tyr Leu Arg Leu Thr Ser Leu Gly Val Ile Gly 
    130                 135                 140                 


Ala Leu Val Lys Thr Asp Glu Gln Glu Val Ile Asn Phe Leu Leu Thr 
145                 150                 155                 160 


Thr Glu Ile Ile Pro Leu Cys Leu Arg Ile Met Glu Ser Gly Ser Glu 
                165                 170                 175     


Leu Ser Lys Thr Val Ala Thr Phe Ile Leu Gln Lys Ile Leu Leu Asp 
            180                 185                 190         


Asp Thr Gly Leu Ala Tyr Ile Cys Gln Thr Tyr Glu Arg Phe Ser His 
        195                 200                 205             


Val Ala Met Ile Leu Gly Lys Met Val Leu Gln Leu Ser Lys Glu Pro 
    210                 215                 220                 


Ser Ala Arg Leu Leu Lys His Val Val Arg Cys Tyr Leu Arg Leu Ser 
225                 230                 235                 240 


Asp Asn Pro Arg Ala Arg Glu Ala Leu Arg Gln Cys Leu Pro Asp Gln 
                245                 250                 255     


Leu Lys Asp Thr Thr Phe Ala Gln Val Leu Lys Asp Asp Thr Thr Thr 
            260                 265                 270         


Lys Arg Trp Leu Ala Gln Leu Val Lys Asn Leu Gln Glu Gly Gln Val 
        275                 280                 285             


Thr Asp Pro Arg Gly Ile Pro Leu Pro Pro Gln 
    290                 295                 


<210>  3103
<211>  299
<212>  PRT
<213>  Homo Sapiens

<400>  3103

Met His Ser Leu Ala Thr Ala Ala Pro Val Pro Thr Thr Leu Ala Gln 
1               5                   10                  15      


Val Asp Arg Glu Lys Ile Tyr Gln Trp Ile Asn Glu Leu Ser Ser Pro 
            20                  25                  30          


Glu Thr Arg Glu Asn Ala Leu Leu Glu Leu Ser Lys Lys Arg Glu Ser 
        35                  40                  45              


Val Pro Asp Leu Ala Pro Met Leu Trp His Ser Phe Gly Thr Ile Ala 
    50                  55                  60                  


Ala Leu Leu Gln Glu Ile Val Asn Ile Tyr Pro Ser Ile Asn Pro Pro 
65                  70                  75                  80  


Thr Leu Thr Ala His Gln Ser Asn Arg Val Cys Asn Ala Leu Ala Leu 
                85                  90                  95      


Leu Gln Cys Val Ala Ser His Pro Glu Thr Arg Ser Ala Phe Leu Ala 
            100                 105                 110         


Ala His Ile Pro Leu Phe Leu Tyr Pro Phe Leu His Thr Val Ser Lys 
        115                 120                 125             


Thr Arg Pro Phe Glu Tyr Leu Arg Leu Thr Ser Leu Gly Val Ile Gly 
    130                 135                 140                 


Ala Leu Val Lys Thr Asp Glu Gln Glu Val Ile Asn Phe Leu Leu Thr 
145                 150                 155                 160 


Thr Glu Ile Ile Pro Leu Cys Leu Arg Ile Met Glu Ser Gly Ser Glu 
                165                 170                 175     


Leu Ser Lys Thr Val Ala Thr Phe Ile Leu Gln Lys Ile Leu Leu Asp 
            180                 185                 190         


Asp Thr Gly Leu Ala Tyr Ile Cys Gln Thr Tyr Glu Arg Phe Ser His 
        195                 200                 205             


Val Ala Met Ile Leu Gly Lys Met Val Leu Gln Leu Ser Lys Glu Pro 
    210                 215                 220                 


Ser Ala Arg Leu Leu Lys His Val Val Arg Cys Tyr Leu Arg Leu Ser 
225                 230                 235                 240 


Asp Asn Pro Arg Ala Arg Glu Ala Leu Arg Gln Cys Leu Pro Asp Gln 
                245                 250                 255     


Leu Lys Asp Thr Thr Phe Ala Gln Val Leu Lys Asp Asp Thr Thr Thr 
            260                 265                 270         


Lys Arg Trp Leu Ala Gln Leu Val Lys Asn Leu Gln Glu Gly Gln Val 
        275                 280                 285             


Thr Asp Pro Arg Gly Ile Pro Leu Pro Pro Gln 
    290                 295                 


<210>  3104
<211>  258
<212>  PRT
<213>  Homo Sapiens

<400>  3104

Met His Ser Leu Ala Thr Ala Ala Pro Val Pro Thr Thr Leu Ala Gln 
1               5                   10                  15      


Val Asp Arg Glu Lys Ile Tyr Gln Trp Ile Asn Glu Leu Ser Ser Pro 
            20                  25                  30          


Glu Thr Arg Glu Asn Ala Leu Leu Glu Leu Ser Lys Lys Arg Glu Ser 
        35                  40                  45              


Val Pro Asp Leu Ala Pro Met Leu Trp His Ser Phe Gly Thr Ile Ala 
    50                  55                  60                  


Ala Leu Leu Gln Glu Ile Val Asn Ile Tyr Pro Ser Ile Asn Pro Pro 
65                  70                  75                  80  


Thr Leu Thr Ala His Gln Ser Asn Arg Val Cys Asn Ala Leu Ala Leu 
                85                  90                  95      


Leu Gln Cys Val Ala Ser His Pro Glu Thr Arg Ser Ala Phe Leu Ala 
            100                 105                 110         


Ala His Ile Pro Leu Phe Leu Tyr Pro Phe Leu His Thr Val Ser Lys 
        115                 120                 125             


Thr Arg Pro Phe Glu Tyr Leu Arg Leu Thr Ser Leu Gly Val Ile Gly 
    130                 135                 140                 


Ala Leu Val Lys Thr Asp Glu Gln Glu Val Ile Asn Phe Leu Leu Thr 
145                 150                 155                 160 


Thr Glu Ile Ile Pro Leu Cys Leu Arg Ile Met Glu Ser Gly Ser Glu 
                165                 170                 175     


Leu Ser Lys Thr Val Ala Thr Phe Ile Leu Gln Lys Ile Leu Leu Asp 
            180                 185                 190         


Asp Thr Gly Leu Ala Tyr Ile Cys Gln Thr Tyr Glu Arg Phe Ser His 
        195                 200                 205             


Val Ala Met Ile Leu Gly Lys Met Val Leu Gln Leu Ser Lys Glu Pro 
    210                 215                 220                 


Ser Ala Arg Leu Leu Lys His Val Val Arg Cys Tyr Leu Arg Leu Ser 
225                 230                 235                 240 


Asp Asn Pro Arg Phe Ser Asp Leu Thr Phe Cys Trp Ser Ser Phe Gln 
                245                 250                 255     


Arg Lys 
        


<210>  3105
<211>  331
<212>  PRT
<213>  Homo Sapiens

<400>  3105

Met His Ser Leu Ala Thr Ala Ala Pro Val Pro Thr Thr Leu Ala Gln 
1               5                   10                  15      


Val Asp Arg Glu Lys Ile Tyr Gln Trp Ile Asn Glu Leu Ser Ser Pro 
            20                  25                  30          


Glu Thr Arg Glu Asn Ala Leu Leu Glu Leu Ser Lys Lys Arg Glu Ser 
        35                  40                  45              


Val Pro Asp Leu Ala Pro Met Leu Trp His Ser Phe Gly Thr Ile Ala 
    50                  55                  60                  


Ala Leu Leu Gln Glu Ile Val Asn Ile Tyr Pro Ser Ile Asn Pro Pro 
65                  70                  75                  80  


Thr Leu Thr Ala His Gln Ser Asn Arg Val Cys Asn Ala Leu Ala Leu 
                85                  90                  95      


Leu Gln Cys Val Ala Ser His Pro Glu Thr Arg Ser Ala Phe Leu Ala 
            100                 105                 110         


Ala His Ile Pro Leu Phe Leu Tyr Pro Phe Leu His Thr Val Ser Lys 
        115                 120                 125             


Thr Arg Pro Phe Glu Tyr Leu Arg Leu Thr Ser Leu Gly Val Ile Val 
    130                 135                 140                 


Glu Thr Gly Phe His His Val Gly Gln Ala Asp Leu Glu Leu Pro Thr 
145                 150                 155                 160 


Ser Ser Asp Leu Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly 
                165                 170                 175     


Ala Leu Val Lys Thr Asp Glu Gln Glu Val Ile Asn Phe Leu Leu Thr 
            180                 185                 190         


Thr Glu Ile Ile Pro Leu Cys Leu Arg Ile Met Glu Ser Gly Ser Glu 
        195                 200                 205             


Leu Ser Lys Thr Val Ala Thr Phe Ile Leu Gln Lys Ile Leu Leu Asp 
    210                 215                 220                 


Asp Thr Gly Leu Ala Tyr Ile Cys Gln Thr Tyr Glu Arg Phe Ser His 
225                 230                 235                 240 


Val Ala Met Ile Leu Gly Lys Met Val Leu Gln Leu Ser Lys Glu Pro 
                245                 250                 255     


Ser Ala Arg Leu Leu Lys His Val Val Arg Cys Tyr Leu Arg Leu Ser 
            260                 265                 270         


Asp Asn Pro Arg Ala Arg Glu Ala Leu Arg Gln Cys Leu Pro Asp Gln 
        275                 280                 285             


Leu Lys Asp Thr Thr Phe Ala Gln Val Leu Lys Asp Asp Thr Thr Thr 
    290                 295                 300                 


Lys Arg Trp Leu Ala Gln Leu Val Lys Asn Leu Gln Glu Gly Gln Val 
305                 310                 315                 320 


Thr Asp Pro Arg Gly Ile Pro Leu Pro Pro Gln 
                325                 330     


<210>  3106
<211>  75
<212>  PRT
<213>  Homo Sapiens

<400>  3106

Met His Ser Leu Ala Thr Ala Ala Pro Val Pro Thr Thr Leu Ala Gln 
1               5                   10                  15      


Val Asp Arg Glu Lys Ile Tyr Gln Trp Ile Asn Glu Leu Ser Ser Pro 
            20                  25                  30          


Glu Thr Arg Glu Asn Ala Leu Leu Glu Leu Ser Lys Lys Arg Glu Ser 
        35                  40                  45              


Val Pro Asp Leu Ala Pro Met Leu Trp His Ser Phe Gly Thr Ile Ala 
    50                  55                  60                  


Ala Leu Leu Gln Val Ile Val Met Gln Val Ile 
65                  70                  75  


<210>  3107
<211>  80
<212>  PRT
<213>  Homo Sapiens

<400>  3107

Lys Asn Tyr Val Arg Val Val Gly Arg Asn Gly Glu Ser Ser Glu Leu 
1               5                   10                  15      


Asp Leu Gln Gly Ile Arg Ile Asp Ser Asp Ile Ser Gly Thr Leu Lys 
            20                  25                  30          


Phe Ala Cys Glu Ser Ile Val Glu Glu Tyr Glu Asp Glu Leu Ile Glu 
        35                  40                  45              


Phe Phe Ser Arg Glu Ala Asp Asn Val Lys Asp Lys Leu Cys Ser Lys 
    50                  55                  60                  


Arg Thr Asp Leu Cys Asp His Ala Leu His Ile Ser His Asp Glu Leu 
65                  70                  75                  80  


<210>  3108
<211>  102
<212>  PRT
<213>  Homo Sapiens

<400>  3108

Met Gly Ser Phe Arg Ile Asn Pro Asp Gly Ser Gln Ser Val Val Glu 
1               5                   10                  15      


Val Pro Tyr Ala Arg Ser Glu Ala His Leu Thr Glu Leu Leu Glu Glu 
            20                  25                  30          


Ile Cys Asp Arg Met Lys Glu Tyr Gly Glu Gln Ile Asp Pro Ser Thr 
        35                  40                  45              


His Arg Lys Asn Tyr Val Arg Val Val Gly Arg Asn Gly Glu Ser Ser 
    50                  55                  60                  


Glu Leu Asp Leu Gln Gly Ile Arg Ile Asp Ser Asp Ile Ser Gly Thr 
65                  70                  75                  80  


Leu Lys Phe Ala Cys Glu Ser Ile Val Glu Glu Tyr Glu Asp Glu Leu 
                85                  90                  95      


Ile Glu Phe Phe Ser Arg 
            100         


<210>  3109
<211>  168
<212>  PRT
<213>  Homo Sapiens

<400>  3109

Met Lys Gly Trp Gly Trp Leu Ala Leu Leu Leu Gly Ala Leu Leu Gly 
1               5                   10                  15      


Thr Ala Trp Ala Arg Arg Ser Gln Asp Leu His Cys Gly Ala Cys Arg 
            20                  25                  30          


Ala Leu Val Asp Glu Leu Glu Trp Glu Ile Ala Gln Val Asp Pro Lys 
        35                  40                  45              


Lys Thr Ile Gln Met Gly Ser Phe Arg Ile Asn Pro Asp Gly Ser Gln 
    50                  55                  60                  


Ser Val Val Glu Val Pro Tyr Ala Arg Ser Glu Ala His Leu Thr Glu 
65                  70                  75                  80  


Leu Leu Glu Glu Ile Cys Asp Arg Met Lys Glu Tyr Gly Glu Gln Ile 
                85                  90                  95      


Asp Pro Ser Thr His Arg Lys Asn Tyr Val Arg Val Val Gly Arg Asn 
            100                 105                 110         


Gly Glu Ser Ser Glu Leu Asp Leu Gln Gly Ile Arg Ile Asp Ser Asp 
        115                 120                 125             


Ile Ser Gly Thr Leu Lys Phe Ala Cys Glu Ser Ile Val Glu Glu Tyr 
    130                 135                 140                 


Glu Asp Glu Leu Ile Glu Phe Phe Ser Arg Glu Ala Asp Asn Val Lys 
145                 150                 155                 160 


Asp Lys Leu Cys Ser Lys Arg Thr 
                165             


<210>  3110
<211>  182
<212>  PRT
<213>  Homo Sapiens

<400>  3110

Met Lys Gly Trp Gly Trp Leu Ala Leu Leu Leu Gly Ala Leu Leu Gly 
1               5                   10                  15      


Thr Ala Trp Ala Arg Arg Ser Gln Asp Leu His Cys Gly Ala Cys Arg 
            20                  25                  30          


Ala Leu Val Asp Glu Leu Glu Trp Glu Ile Ala Gln Val Asp Pro Lys 
        35                  40                  45              


Lys Thr Ile Gln Met Gly Ser Phe Arg Ile Asn Pro Asp Gly Ser Gln 
    50                  55                  60                  


Ser Val Val Glu Val Pro Tyr Ala Arg Ser Glu Ala His Leu Thr Glu 
65                  70                  75                  80  


Leu Leu Glu Glu Ile Cys Asp Arg Met Lys Glu Tyr Gly Glu Gln Ile 
                85                  90                  95      


Asp Pro Ser Thr His Arg Lys Asn Tyr Val Arg Val Val Gly Arg Asn 
            100                 105                 110         


Gly Glu Ser Ser Glu Leu Asp Leu Gln Gly Ile Arg Ile Asp Ser Asp 
        115                 120                 125             


Ile Ser Gly Thr Leu Lys Phe Ala Cys Glu Ser Ile Val Glu Glu Tyr 
    130                 135                 140                 


Glu Asp Glu Leu Ile Glu Phe Phe Ser Arg Glu Ala Asp Asn Val Lys 
145                 150                 155                 160 


Asp Lys Leu Cys Ser Lys Arg Thr Asp Leu Cys Asp His Ala Leu His 
                165                 170                 175     


Ile Ser His Asp Glu Leu 
            180         


<210>  3111
<211>  41
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3111

Xaa Ala Cys Arg Ala Leu Val Asp Glu Leu Glu Trp Glu Ile Ala Gln 
1               5                   10                  15      


Val Asp Pro Lys Lys Thr Ile Gln Met Gly Ser Phe Arg Ile Asn Pro 
            20                  25                  30          


Asp Gly Ser Gln Ser Val Val Glu Arg 
        35                  40      


<210>  3112
<211>  278
<212>  PRT
<213>  Homo Sapiens

<400>  3112

Met Asp Ser Met Pro Glu Pro Ala Ser Arg Cys Leu Leu Leu Leu Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Leu Pro Ala Pro Glu Leu Gly Pro 
            20                  25                  30          


Ser Gln Ala Gly Ala Glu Glu Asn Asp Trp Val Arg Leu Pro Ser Lys 
        35                  40                  45              


Cys Glu Val Cys Lys Tyr Val Ala Val Glu Leu Lys Ser Ala Phe Glu 
    50                  55                  60                  


Glu Thr Gly Lys Thr Lys Glu Val Ile Gly Thr Gly Tyr Gly Ile Leu 
65                  70                  75                  80  


Asp Gln Lys Ala Ser Gly Val Lys Tyr Thr Lys Ser Asp Leu Arg Leu 
                85                  90                  95      


Ile Glu Val Thr Glu Thr Ile Cys Lys Arg Leu Leu Asp Tyr Ser Leu 
            100                 105                 110         


His Lys Glu Arg Thr Gly Ser Asn Arg Phe Ala Lys Gly Met Ser Glu 
        115                 120                 125             


Thr Phe Glu Thr Leu His Asn Leu Val His Lys Gly Val Lys Val Val 
    130                 135                 140                 


Met Asp Ile Pro Tyr Glu Leu Trp Asn Glu Thr Ser Ala Glu Val Ala 
145                 150                 155                 160 


Asp Leu Lys Lys Gln Cys Asp Val Leu Val Glu Glu Phe Glu Glu Val 
                165                 170                 175     


Ile Glu Asp Trp Tyr Arg Asn His Gln Glu Glu Asp Leu Thr Glu Phe 
            180                 185                 190         


Leu Cys Ala Asn His Val Leu Lys Gly Lys Asp Thr Ser Cys Leu Ala 
        195                 200                 205             


Glu Gln Trp Ser Gly Lys Lys Gly Asp Thr Ala Ala Leu Gly Gly Lys 
    210                 215                 220                 


Lys Ser Lys Lys Lys Ser Ser Arg Ala Lys Ala Ala Gly Gly Arg Ser 
225                 230                 235                 240 


Ser Ser Ser Lys Gln Arg Lys Glu Leu Gly Gly Leu Glu Gly Asp Pro 
                245                 250                 255     


Ser Pro Glu Glu Asp Glu Gly Ile Gln Lys Ala Ser Pro Leu Thr His 
            260                 265                 270         


Ser Pro Pro Asp Glu Leu 
        275             


<210>  3113
<211>  143
<212>  PRT
<213>  Homo Sapiens

<400>  3113

Met Asp Ser Met Pro Glu Pro Ala Ser Arg Cys Leu Leu Leu Leu Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Leu Pro Ala Pro Glu Leu Gly Pro 
            20                  25                  30          


Ser Gln Ala Gly Ala Glu Glu Asn Asp Trp Val Arg Leu Pro Ser Lys 
        35                  40                  45              


Cys Glu Val Cys Lys Tyr Val Ala Val Glu Leu Lys Ser Ala Phe Glu 
    50                  55                  60                  


Glu Thr Gly Lys Thr Lys Glu Val Ile Gly Thr Gly Tyr Gly Ile Leu 
65                  70                  75                  80  


Asp Gln Lys Ala Ser Gly Val Lys Tyr Thr Lys Ser Asp Leu Arg Leu 
                85                  90                  95      


Ile Glu Val Thr Glu Thr Ile Cys Lys Arg Leu Leu Ile Ile Ala Cys 
            100                 105                 110         


Thr Arg Arg Gly Pro Ala Ala Ile Asp Leu Pro Arg Ala Cys Gln Arg 
        115                 120                 125             


Pro Leu Arg His Tyr Thr Thr Trp Tyr Thr Lys Gly Ser Arg Trp 
    130                 135                 140             


<210>  3114
<211>  36
<212>  PRT
<213>  Homo Sapiens

<400>  3114

Met Ala Thr Leu Lys Gly Leu Val Gln Lys Gly Val Lys Val Asp Leu 
1               5                   10                  15      


Gly Ile Pro Leu Glu Leu Trp Asp Glu Pro Ser Val Glu Val Thr Tyr 
            20                  25                  30          


Leu Lys Lys Gln 
        35      


<210>  3115
<211>  248
<212>  PRT
<213>  Homo Sapiens

<400>  3115

Met Gly Pro Val Arg Leu Gly Ile Leu Leu Phe Leu Phe Leu Ala Val 
1               5                   10                  15      


His Glu Ala Trp Ala Gly Met Leu Lys Glu Glu Asp Asp Asp Thr Glu 
            20                  25                  30          


Arg Leu Pro Ser Lys Cys Glu Val Cys Lys Leu Leu Ser Thr Glu Leu 
        35                  40                  45              


Gln Ala Glu Leu Ser Arg Thr Gly Arg Ser Arg Glu Val Leu Glu Leu 
    50                  55                  60                  


Gly Gln Val Leu Asp Thr Gly Lys Arg Lys Arg His Val Pro Tyr Ser 
65                  70                  75                  80  


Val Ser Glu Thr Arg Leu Glu Glu Ala Leu Glu Asn Leu Cys Glu Arg 
                85                  90                  95      


Ile Leu Asp Tyr Ser Val His Ala Glu Arg Lys Gly Ser Leu Arg Tyr 
            100                 105                 110         


Ala Lys Gly Gln Ser Gln Thr Met Ala Thr Leu Lys Gly Leu Val Gln 
        115                 120                 125             


Lys Gly Val Lys Val Asp Leu Gly Ile Pro Leu Glu Leu Trp Asp Glu 
    130                 135                 140                 


Pro Ser Val Glu Val Thr Tyr Leu Lys Lys Gln Cys Glu Thr Met Leu 
145                 150                 155                 160 


Glu Glu Phe Glu Asp Ile Val Gly Asp Trp Tyr Phe His His Gln Glu 
                165                 170                 175     


Gln Pro Leu Gln Asn Phe Leu Cys Glu Gly His Val Leu Pro Ala Ala 
            180                 185                 190         


Glu Thr Ala Cys Leu Gln Glu Thr Trp Thr Gly Lys Glu Ile Thr Asp 
        195                 200                 205             


Gly Glu Glu Lys Thr Glu Gly Glu Glu Glu Gln Glu Glu Glu Glu Glu 
    210                 215                 220                 


Glu Glu Glu Glu Glu Gly Gly Asp Lys Met Thr Lys Thr Gly Ser His 
225                 230                 235                 240 


Pro Lys Leu Asp Arg Glu Asp Leu 
                245             


<210>  3116
<211>  118
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3116

Xaa Cys Lys Leu Leu Ser Thr Glu Leu Gln Ala Glu Leu Ser Arg Thr 
1               5                   10                  15      


Gly Arg Ser Arg Glu Val Leu Glu Leu Gly Gln Val Leu Asp Thr Gly 
            20                  25                  30          


Lys Arg Lys Arg His Val Pro Tyr Ser Val Ser Glu Thr Arg Leu Glu 
        35                  40                  45              


Glu Ala Leu Glu Asn Leu Cys Glu Arg Ile Leu Asp Tyr Ser Val His 
    50                  55                  60                  


Ala Glu Arg Lys Gly Ser Leu Arg Tyr Ala Lys Gly Gln Ser Gln Thr 
65                  70                  75                  80  


Met Ala Thr Leu Lys Gly Leu Val Gln Lys Gly Val Lys Val Asp Leu 
                85                  90                  95      


Gly Ile Pro Leu Glu Leu Trp Asp Glu Pro Ser Val Glu Val Thr Tyr 
            100                 105                 110         


Leu Lys Lys Gln Ser Gly 
        115             


<210>  3117
<211>  372
<212>  PRT
<213>  Homo Sapiens

<400>  3117

Met Ala Ala Pro Val Pro Trp Ala Cys Cys Ala Val Leu Ala Ala Ala 
1               5                   10                  15      


Ala Ala Val Val Tyr Ala Gln Arg His Ser Pro Gln Glu Ala Pro His 
            20                  25                  30          


Val Gln Tyr Glu Arg Leu Gly Ser Asp Val Thr Leu Pro Cys Gly Thr 
        35                  40                  45              


Ala Asn Trp Asp Ala Ala Val Thr Trp Arg Val Asn Gly Thr Asp Leu 
    50                  55                  60                  


Ala Pro Asp Leu Leu Asn Gly Ser Gln Leu Val Leu His Gly Leu Glu 
65                  70                  75                  80  


Leu Gly His Ser Gly Leu Tyr Ala Cys Phe His Arg Asp Ser Trp His 
                85                  90                  95      


Leu Arg His Gln Val Leu Leu His Val Gly Leu Pro Pro Arg Glu Pro 
            100                 105                 110         


Val Leu Ser Cys Arg Ser Asn Thr Tyr Pro Lys Gly Phe Tyr Cys Ser 
        115                 120                 125             


Trp His Leu Pro Thr Pro Thr Tyr Ile Pro Asn Thr Phe Asn Val Thr 
    130                 135                 140                 


Val Leu His Gly Ser Lys Ile Met Val Cys Glu Lys Asp Pro Ala Leu 
145                 150                 155                 160 


Lys Asn Arg Cys His Ile Arg Tyr Met His Leu Phe Ser Thr Ile Lys 
                165                 170                 175     


Tyr Lys Val Ser Ile Ser Val Ser Asn Ala Leu Gly His Asn Ala Thr 
            180                 185                 190         


Ala Ile Thr Phe Asp Glu Phe Thr Ile Val Lys Pro Asp Pro Pro Glu 
        195                 200                 205             


Asn Val Val Ala Arg Pro Val Pro Ser Asn Pro Arg Arg Leu Glu Val 
    210                 215                 220                 


Thr Trp Gln Thr Pro Ser Thr Trp Pro Asp Pro Glu Ser Phe Pro Leu 
225                 230                 235                 240 


Lys Phe Phe Leu Arg Tyr Arg Pro Leu Ile Leu Asp Gln Trp Gln His 
                245                 250                 255     


Val Glu Leu Ser Asp Gly Thr Ala His Thr Ile Thr Asp Ala Tyr Ala 
            260                 265                 270         


Gly Lys Glu Tyr Ile Ile Gln Val Ala Ala Lys Asp Asn Glu Ile Gly 
        275                 280                 285             


Thr Trp Ser Asp Trp Ser Val Ala Ala His Ala Thr Pro Trp Thr Glu 
    290                 295                 300                 


Glu Pro Arg His Leu Thr Thr Glu Ala Gln Ala Ala Glu Thr Thr Thr 
305                 310                 315                 320 


Ser Thr Thr Ser Ser Leu Ala Pro Pro Pro Thr Thr Lys Ile Cys Asp 
                325                 330                 335     


Pro Gly Glu Leu Gly Ser Gly Gly Gly Pro Ser Ala Pro Phe Leu Val 
            340                 345                 350         


Ser Val Pro Ile Thr Leu Ala Leu Ala Ala Ala Ala Ala Thr Ala Ser 
        355                 360                 365             


Ser Leu Leu Ile 
    370         


<210>  3118
<211>  372
<212>  PRT
<213>  Homo Sapiens

<400>  3118

Met Ala Ala Pro Val Pro Trp Ala Cys Cys Ala Val Leu Ala Ala Ala 
1               5                   10                  15      


Ala Ala Val Val Tyr Ala Gln Arg His Ser Pro Gln Glu Ala Pro His 
            20                  25                  30          


Val Gln Tyr Glu Arg Leu Gly Ser Asp Val Thr Leu Pro Cys Gly Thr 
        35                  40                  45              


Ala Asn Trp Asp Ala Ala Val Thr Trp Arg Val Asn Gly Thr Asp Leu 
    50                  55                  60                  


Ala Pro Asp Leu Leu Asn Gly Ser Gln Leu Val Leu His Gly Leu Glu 
65                  70                  75                  80  


Leu Gly His Ser Gly Leu Tyr Ala Cys Phe His Arg Asp Ser Trp His 
                85                  90                  95      


Leu Arg His Gln Val Leu Leu His Val Gly Leu Pro Pro Arg Glu Pro 
            100                 105                 110         


Val Leu Ser Cys Arg Ser Asn Thr Tyr Pro Lys Gly Phe Tyr Cys Ser 
        115                 120                 125             


Trp His Leu Pro Thr Pro Thr Tyr Ile Pro Asn Thr Phe Asn Val Thr 
    130                 135                 140                 


Val Leu His Gly Ser Lys Ile Met Val Cys Glu Lys Asp Pro Ala Leu 
145                 150                 155                 160 


Lys Asn Arg Cys His Ile Arg Tyr Met His Leu Phe Ser Thr Ile Lys 
                165                 170                 175     


Tyr Lys Val Ser Ile Ser Val Ser Asn Ala Leu Gly His Asn Ala Thr 
            180                 185                 190         


Ala Ile Thr Phe Asp Glu Phe Thr Ile Val Lys Pro Asp Pro Pro Glu 
        195                 200                 205             


Asn Val Val Ala Arg Pro Val Pro Ser Asn Pro Arg Arg Leu Glu Val 
    210                 215                 220                 


Thr Trp Gln Thr Pro Ser Thr Trp Pro Asp Pro Glu Ser Phe Pro Leu 
225                 230                 235                 240 


Lys Phe Phe Leu Arg Tyr Arg Pro Leu Ile Leu Asp Gln Trp Gln His 
                245                 250                 255     


Val Glu Leu Ser Asp Gly Thr Ala His Thr Ile Thr Asp Ala Tyr Ala 
            260                 265                 270         


Gly Lys Glu Tyr Ile Ile Gln Val Ala Ala Lys Asp Asn Glu Ile Gly 
        275                 280                 285             


Thr Trp Ser Asp Trp Ser Val Ala Ala His Ala Thr Pro Trp Thr Glu 
    290                 295                 300                 


Glu Pro Arg His Leu Thr Thr Glu Ala Gln Ala Ala Glu Thr Thr Thr 
305                 310                 315                 320 


Ser Thr Thr Ser Ser Leu Ala Pro Pro Pro Thr Thr Lys Ile Cys Asp 
                325                 330                 335     


Pro Gly Glu Leu Gly Ser Gly Gly Gly Pro Ser Ala Pro Phe Leu Val 
            340                 345                 350         


Ser Val Pro Ile Thr Leu Ala Leu Ala Ala Ala Ala Ala Thr Ala Ser 
        355                 360                 365             


Ser Leu Leu Ile 
    370         


<210>  3119
<211>  256
<212>  PRT
<213>  Homo Sapiens

<400>  3119

Met Ala Ala Pro Val Pro Trp Ala Cys Cys Ala Val Leu Ala Ala Ala 
1               5                   10                  15      


Ala Ala Val Val Tyr Ala Gln Arg His Ser Pro Gln Glu Ala Pro His 
            20                  25                  30          


Val Gln Tyr Glu Arg Leu Gly Ser Asp Val Thr Leu Pro Cys Gly Thr 
        35                  40                  45              


Ala Asn Trp Asp Ala Ala Val Thr Trp Arg Val Asn Gly Thr Asp Leu 
    50                  55                  60                  


Ala Pro Asp Leu Leu Asn Gly Ser Gln Leu Val Leu His Gly Leu Glu 
65                  70                  75                  80  


Leu Gly His Ser Gly Leu Tyr Ala Cys Phe His Arg Asp Ser Trp His 
                85                  90                  95      


Leu Arg His Gln Val Leu Leu His Val Gly Leu Pro Pro Arg Glu Pro 
            100                 105                 110         


Val Leu Ser Cys Arg Ser Asn Thr Tyr Pro Lys Gly Phe Tyr Cys Ser 
        115                 120                 125             


Trp His Leu Pro Thr Pro Thr Tyr Ile Pro Asn Thr Phe Asn Val Thr 
    130                 135                 140                 


Val Leu His Gly Ser Lys Ile Met Val Cys Glu Lys Asp Pro Ala Leu 
145                 150                 155                 160 


Lys Asn Arg Cys His Ile Arg Tyr Met His Leu Phe Ser Thr Ile Lys 
                165                 170                 175     


Tyr Lys Val Ser Ile Ser Val Ser Asn Ala Leu Gly His Asn Ala Thr 
            180                 185                 190         


Ala Ile Thr Phe Asp Glu Phe Thr Ile Val Lys Pro Asp Pro Pro Glu 
        195                 200                 205             


Asn Val Val Ala Arg Pro Val Pro Ser Asn Pro Arg Arg Leu Glu Val 
    210                 215                 220                 


Thr Trp Gln Thr Pro Ser Thr Trp Pro Asp Pro Glu Ser Phe Pro Leu 
225                 230                 235                 240 


Lys Phe Phe Leu Arg Tyr Arg Pro Leu Ile Leu Asp Gln Trp Gln His 
                245                 250                 255     


<210>  3120
<211>  372
<212>  PRT
<213>  Homo Sapiens

<400>  3120

Met Ala Ala Pro Val Pro Trp Ala Cys Cys Ala Val Leu Ala Ala Ala 
1               5                   10                  15      


Ala Ala Val Val Tyr Ala Gln Arg His Ser Pro Gln Glu Ala Pro His 
            20                  25                  30          


Val Gln Tyr Glu Arg Leu Gly Ser Asp Val Thr Leu Pro Cys Gly Thr 
        35                  40                  45              


Ala Asn Trp Asp Ala Ala Val Thr Trp Arg Val Asn Gly Thr Asp Leu 
    50                  55                  60                  


Ala Pro Asp Leu Leu Asn Gly Ser Gln Leu Val Leu His Gly Leu Glu 
65                  70                  75                  80  


Leu Gly His Ser Gly Leu Tyr Ala Cys Phe His Arg Asp Ser Trp His 
                85                  90                  95      


Leu Arg His Gln Val Leu Leu His Val Gly Leu Pro Pro Arg Glu Pro 
            100                 105                 110         


Val Leu Ser Cys Arg Ser Asn Thr Tyr Pro Lys Gly Phe Tyr Cys Ser 
        115                 120                 125             


Trp His Leu Pro Thr Pro Thr Tyr Ile Pro Asn Thr Phe Asn Val Thr 
    130                 135                 140                 


Val Leu His Gly Ser Lys Ile Met Val Cys Glu Lys Asp Pro Ala Leu 
145                 150                 155                 160 


Lys Asn Arg Cys His Ile Arg Tyr Met His Leu Phe Ser Thr Ile Lys 
                165                 170                 175     


Tyr Lys Val Ser Ile Ser Val Ser Asn Ala Leu Gly His Asn Ala Thr 
            180                 185                 190         


Ala Ile Thr Phe Asp Glu Phe Thr Ile Val Lys Pro Asp Pro Pro Glu 
        195                 200                 205             


Asn Val Val Ala Arg Pro Val Pro Ser Asn Pro Arg Arg Leu Glu Val 
    210                 215                 220                 


Thr Trp Gln Thr Pro Ser Thr Trp Pro Asp Pro Glu Ser Phe Pro Leu 
225                 230                 235                 240 


Lys Phe Phe Leu Arg Tyr Arg Pro Leu Ile Leu Asp Gln Trp Gln His 
                245                 250                 255     


Val Glu Leu Ser Asp Gly Thr Ala His Thr Ile Thr Asp Ala Tyr Ala 
            260                 265                 270         


Gly Lys Glu Tyr Ile Ile Gln Val Ala Ala Lys Asp Asn Glu Ile Gly 
        275                 280                 285             


Thr Trp Ser Asp Trp Ser Val Ala Ala His Ala Thr Pro Trp Thr Glu 
    290                 295                 300                 


Glu Pro Arg His Leu Thr Thr Glu Ala Gln Ala Ala Glu Thr Thr Thr 
305                 310                 315                 320 


Ser Thr Thr Ser Ser Leu Ala Pro Pro Pro Thr Thr Lys Ile Cys Asp 
                325                 330                 335     


Pro Gly Glu Leu Gly Ser Gly Gly Gly Pro Ser Ala Pro Phe Leu Val 
            340                 345                 350         


Ser Val Pro Ile Thr Leu Ala Leu Ala Ala Ala Ala Ala Thr Ala Ser 
        355                 360                 365             


Ser Leu Leu Ile 
    370         


<210>  3121
<211>  57
<212>  PRT
<213>  Homo Sapiens

<400>  3121

Lys His Ser Ile Glu Val Pro Ile Pro Arg Asp Gly Glu Tyr Val Val 
1               5                   10                  15      


Glu Val Arg Ala His Ser Asp Gly Gly Asp Gly Val Val Ser Gln Val 
            20                  25                  30          


Lys Ile Ser Glu Gly Lys Ser Thr Ser Leu Arg Ser Lys Thr Ala Lys 
        35                  40                  45              


Asp His Arg Ser Ile Arg Thr Met Ser 
    50                  55          


<210>  3122
<211>  63
<212>  PRT
<213>  Homo Sapiens

<400>  3122

Met Lys Met Trp Leu Leu Val Ser His Leu Val Ile Ile Ser Ile Thr 
1               5                   10                  15      


Thr Cys Leu Ala Glu Phe Thr Trp Tyr Arg Arg Tyr Gly His Gly Val 
            20                  25                  30          


Ser Glu Glu Asp Lys Gly Phe Gly Pro Ile Phe Glu Glu Gln Pro Ile 
        35                  40                  45              


Asn Thr Ile Tyr Pro Glu Glu Ser Leu Glu Gly Lys Val Ser Leu 
    50                  55                  60              


<210>  3123
<211>  73
<212>  PRT
<213>  Homo Sapiens

<400>  3123

Met Lys Met Trp Leu Leu Val Ser His Leu Val Ile Ile Ser Ile Thr 
1               5                   10                  15      


Thr Cys Leu Ala Glu Phe Thr Trp Tyr Arg Arg Tyr Gly His Gly Val 
            20                  25                  30          


Ser Glu Glu Asp Lys Gly Phe Gly Pro Ile Phe Glu Glu Gln Pro Ile 
        35                  40                  45              


Asn Thr Ile Tyr Pro Glu Glu Ser Leu Glu Gly Lys Val Ser Leu Asn 
    50                  55                  60                  


Cys Arg Ala Arg Ala Ser Pro Phe Pro 
65                  70              


<210>  3124
<211>  85
<212>  PRT
<213>  Homo Sapiens

<400>  3124

Met Lys Met Trp Leu Leu Val Ser His Leu Val Ile Ile Ser Ile Thr 
1               5                   10                  15      


Thr Cys Leu Ala Glu Phe Thr Trp Tyr Arg Arg Tyr Gly His Gly Val 
            20                  25                  30          


Ser Glu Glu Asp Lys Gly Phe Gly Pro Ile Phe Glu Glu Gln Pro Ile 
        35                  40                  45              


Asn Thr Ile Tyr Pro Glu Glu Ser Leu Glu Gly Lys Val Ser Leu Asn 
    50                  55                  60                  


Cys Arg Ala Arg Ala Ser Pro Phe Pro Val Tyr Lys Trp Arg Met Asn 
65                  70                  75                  80  


Asn Gly Asp Val Asp 
                85  


<210>  3125
<211>  90
<212>  PRT
<213>  Homo Sapiens

<400>  3125

Met Lys Met Trp Leu Leu Val Ser His Leu Val Ile Ile Ser Ile Thr 
1               5                   10                  15      


Thr Cys Leu Ala Glu Phe Thr Trp Tyr Arg Arg Tyr Gly His Gly Val 
            20                  25                  30          


Ser Glu Glu Asp Lys Gly Phe Gly Pro Ile Phe Glu Glu Gln Pro Ile 
        35                  40                  45              


Asn Thr Ile Tyr Pro Glu Glu Ser Leu Glu Gly Lys Val Ser Leu Asn 
    50                  55                  60                  


Cys Arg Ala Arg Ala Ser Pro Phe Pro Val Tyr Lys Trp Arg Met Asn 
65                  70                  75                  80  


Asn Gly Asp Val Asp Leu Thr Ser Asp Arg 
                85                  90  


<210>  3126
<211>  1018
<212>  PRT
<213>  Homo Sapiens

<400>  3126

Met Lys Met Trp Leu Leu Val Ser His Leu Val Ile Ile Ser Ile Thr 
1               5                   10                  15      


Thr Cys Leu Ala Glu Phe Thr Trp Tyr Arg Arg Tyr Gly His Gly Val 
            20                  25                  30          


Ser Glu Glu Asp Lys Gly Phe Gly Pro Ile Phe Glu Glu Gln Pro Ile 
        35                  40                  45              


Asn Thr Ile Tyr Pro Glu Glu Ser Leu Glu Gly Lys Val Ser Leu Asn 
    50                  55                  60                  


Cys Arg Ala Arg Ala Ser Pro Phe Pro Val Tyr Lys Trp Arg Met Asn 
65                  70                  75                  80  


Asn Gly Asp Val Asp Leu Thr Ser Asp Arg Tyr Ser Met Val Gly Gly 
                85                  90                  95      


Asn Leu Val Ile Asn Asn Pro Asp Lys Gln Lys Asp Ala Gly Ile Tyr 
            100                 105                 110         


Tyr Cys Leu Ala Ser Asn Asn Tyr Gly Met Val Arg Ser Thr Glu Ala 
        115                 120                 125             


Thr Leu Ser Phe Gly Tyr Leu Asp Pro Phe Pro Pro Glu Glu Arg Pro 
    130                 135                 140                 


Glu Val Arg Val Lys Glu Gly Lys Gly Met Val Leu Leu Cys Asp Pro 
145                 150                 155                 160 


Pro Tyr His Phe Pro Asp Asp Leu Ser Tyr Arg Trp Leu Leu Asn Glu 
                165                 170                 175     


Phe Pro Val Phe Ile Thr Met Asp Lys Arg Arg Phe Val Ser Gln Thr 
            180                 185                 190         


Asn Gly Asn Leu Tyr Ile Ala Asn Val Glu Ala Ser Asp Lys Gly Asn 
        195                 200                 205             


Tyr Ser Cys Phe Val Ser Ser Pro Ser Ile Thr Lys Ser Val Phe Ser 
    210                 215                 220                 


Lys Phe Ile Pro Leu Ile Pro Ile Pro Glu Arg Thr Thr Lys Pro Tyr 
225                 230                 235                 240 


Pro Ala Asp Ile Val Val Gln Phe Lys Asp Val Tyr Ala Leu Met Gly 
                245                 250                 255     


Gln Asn Val Thr Leu Glu Cys Phe Ala Leu Gly Asn Pro Val Pro Asp 
            260                 265                 270         


Ile Arg Trp Arg Lys Val Leu Glu Pro Met Pro Ser Thr Ala Glu Ile 
        275                 280                 285             


Ser Thr Ser Gly Ala Val Leu Lys Ile Phe Asn Ile Gln Leu Glu Asp 
    290                 295                 300                 


Glu Gly Ile Tyr Glu Cys Glu Ala Glu Asn Ile Arg Gly Lys Asp Lys 
305                 310                 315                 320 


His Gln Ala Arg Ile Tyr Val Gln Ala Phe Pro Glu Trp Val Glu His 
                325                 330                 335     


Ile Asn Asp Thr Glu Val Asp Ile Gly Ser Asp Leu Tyr Trp Pro Cys 
            340                 345                 350         


Val Ala Thr Gly Lys Pro Ile Pro Thr Ile Arg Trp Leu Lys Asn Gly 
        355                 360                 365             


Tyr Ala Tyr His Lys Gly Glu Leu Arg Leu Tyr Asp Val Thr Phe Glu 
    370                 375                 380                 


Asn Ala Gly Met Tyr Gln Cys Ile Ala Glu Asn Thr Tyr Gly Ala Ile 
385                 390                 395                 400 


Tyr Ala Asn Ala Glu Leu Lys Ile Leu Ala Leu Ala Pro Thr Phe Glu 
                405                 410                 415     


Met Asn Pro Met Lys Lys Lys Ile Leu Ala Ala Lys Gly Gly Arg Val 
            420                 425                 430         


Ile Ile Glu Cys Lys Pro Lys Ala Ala Pro Lys Pro Lys Phe Ser Trp 
        435                 440                 445             


Ser Lys Gly Thr Glu Trp Leu Val Asn Ser Ser Arg Ile Leu Ile Trp 
    450                 455                 460                 


Glu Asp Gly Ser Leu Glu Ile Asn Asn Ile Thr Arg Asn Asp Gly Gly 
465                 470                 475                 480 


Ile Tyr Thr Cys Phe Ala Glu Asn Asn Arg Gly Lys Ala Asn Ser Thr 
                485                 490                 495     


Gly Thr Leu Val Ile Thr Asp Pro Thr Arg Ile Ile Leu Ala Pro Ile 
            500                 505                 510         


Asn Ala Asp Ile Thr Val Gly Glu Asn Ala Thr Met Gln Cys Ala Ala 
        515                 520                 525             


Ser Phe Asp Pro Ala Leu Asp Leu Thr Phe Val Trp Ser Phe Asn Gly 
    530                 535                 540                 


Tyr Val Ile Asp Phe Asn Lys Glu Asn Ile His Tyr Gln Arg Asn Phe 
545                 550                 555                 560 


Met Leu Asp Ser Asn Gly Glu Leu Leu Ile Arg Asn Ala Gln Leu Lys 
                565                 570                 575     


His Ala Gly Arg Tyr Thr Cys Thr Ala Gln Thr Ile Val Asp Asn Ser 
            580                 585                 590         


Ser Ala Ser Ala Asp Leu Val Val Arg Gly Pro Pro Gly Pro Pro Gly 
        595                 600                 605             


Gly Leu Arg Ile Glu Asp Ile Arg Ala Thr Ser Val Ala Leu Thr Trp 
    610                 615                 620                 


Ser Arg Gly Ser Asp Asn His Ser Pro Ile Ser Lys Tyr Thr Ile Gln 
625                 630                 635                 640 


Thr Lys Thr Ile Leu Ser Asp Asp Trp Lys Asp Ala Lys Thr Asp Pro 
                645                 650                 655     


Pro Ile Ile Glu Gly Asn Met Glu Ala Ala Arg Ala Val Asp Leu Ile 
            660                 665                 670         


Pro Trp Met Glu Tyr Glu Phe Arg Val Val Ala Thr Asn Thr Leu Gly 
        675                 680                 685             


Arg Gly Glu Pro Ser Ile Pro Ser Asn Arg Ile Lys Thr Asp Gly Ala 
    690                 695                 700                 


Ala Pro Asn Val Ala Pro Ser Asp Val Gly Gly Gly Gly Gly Arg Asn 
705                 710                 715                 720 


Arg Glu Leu Thr Ile Thr Trp Ala Pro Leu Ser Arg Glu Tyr His Tyr 
                725                 730                 735     


Gly Asn Asn Phe Gly Tyr Ile Val Ala Phe Lys Pro Phe Asp Gly Glu 
            740                 745                 750         


Glu Trp Lys Lys Val Thr Val Thr Asn Pro Asp Thr Gly Arg Tyr Val 
        755                 760                 765             


His Lys Asp Glu Thr Met Ser Pro Ser Thr Ala Phe Gln Val Lys Val 
    770                 775                 780                 


Lys Ala Phe Asn Asn Lys Gly Asp Gly Pro Tyr Ser Leu Val Ala Val 
785                 790                 795                 800 


Ile Asn Ser Ala Gln Asp Ala Pro Ser Glu Ala Pro Thr Glu Val Gly 
                805                 810                 815     


Val Lys Val Leu Ser Ser Ser Glu Ile Ser Val His Trp Glu His Val 
            820                 825                 830         


Leu Glu Lys Ile Val Glu Ser Tyr Gln Ile Arg Tyr Trp Ala Ala His 
        835                 840                 845             


Asp Lys Glu Glu Ala Ala Asn Arg Val Gln Val Thr Ser Gln Glu Tyr 
    850                 855                 860                 


Ser Ala Arg Leu Glu Asn Leu Leu Pro Asp Thr Gln Tyr Phe Ile Glu 
865                 870                 875                 880 


Val Gly Ala Cys Asn Ser Ala Gly Cys Gly Pro Pro Ser Asp Met Ile 
                885                 890                 895     


Glu Ala Phe Thr Lys Lys Ala Pro Pro Ser Gln Pro Pro Arg Ile Ile 
            900                 905                 910         


Ser Ser Val Arg Ser Gly Ser Arg Tyr Ile Ile Thr Trp Asp His Val 
        915                 920                 925             


Val Ala Leu Ser Asn Glu Ser Thr Val Thr Gly Tyr Lys Val Leu Tyr 
    930                 935                 940                 


Arg Pro Asp Gly Gln His Asp Gly Lys Leu Tyr Ser Thr His Lys His 
945                 950                 955                 960 


Ser Ile Glu Val Pro Ile Pro Arg Asp Gly Glu Tyr Val Val Glu Val 
                965                 970                 975     


Arg Ala His Ser Asp Gly Gly Asp Gly Val Val Ser Gln Val Lys Ile 
            980                 985                 990         


Ser Gly Ala Pro Thr Leu Ser Pro  Ser Leu Leu Gly Leu  Leu Leu Pro 
        995                 1000                 1005             


Ala Phe  Gly Ile Leu Val Tyr  Leu Glu Phe 
    1010                 1015             


<210>  3127
<211>  1018
<212>  PRT
<213>  Homo Sapiens

<400>  3127

Met Lys Met Trp Leu Leu Val Ser His Leu Val Ile Ile Ser Ile Thr 
1               5                   10                  15      


Thr Cys Leu Ala Glu Phe Thr Trp Tyr Arg Arg Tyr Gly His Gly Val 
            20                  25                  30          


Ser Glu Glu Asp Lys Gly Phe Gly Pro Ile Phe Glu Glu Gln Pro Ile 
        35                  40                  45              


Asn Thr Ile Tyr Pro Glu Glu Ser Leu Glu Gly Lys Val Ser Leu Asn 
    50                  55                  60                  


Cys Arg Ala Arg Ala Ser Pro Phe Pro Val Tyr Lys Trp Arg Met Asn 
65                  70                  75                  80  


Asn Gly Asp Val Asp Leu Thr Ser Asp Arg Tyr Ser Met Val Gly Gly 
                85                  90                  95      


Asn Leu Val Ile Asn Asn Pro Asp Lys Gln Lys Asp Ala Gly Ile Tyr 
            100                 105                 110         


Tyr Cys Leu Ala Ser Asn Asn Tyr Gly Met Val Arg Ser Thr Glu Ala 
        115                 120                 125             


Thr Leu Ser Phe Gly Tyr Leu Asp Pro Phe Pro Pro Glu Glu Arg Pro 
    130                 135                 140                 


Glu Val Arg Val Lys Glu Gly Lys Gly Met Val Leu Leu Cys Asp Pro 
145                 150                 155                 160 


Pro Tyr His Phe Pro Asp Asp Leu Ser Tyr Arg Trp Leu Leu Asn Glu 
                165                 170                 175     


Phe Pro Val Phe Ile Thr Met Asp Lys Arg Arg Phe Val Ser Gln Thr 
            180                 185                 190         


Asn Gly Asn Leu Tyr Ile Ala Asn Val Glu Ala Ser Asp Lys Gly Asn 
        195                 200                 205             


Tyr Ser Cys Phe Val Ser Ser Pro Ser Ile Thr Lys Ser Val Phe Ser 
    210                 215                 220                 


Lys Phe Ile Pro Leu Ile Pro Ile Pro Glu Arg Thr Thr Lys Pro Tyr 
225                 230                 235                 240 


Pro Ala Asp Ile Val Val Gln Phe Lys Asp Val Tyr Ala Leu Met Gly 
                245                 250                 255     


Gln Asn Val Thr Leu Glu Cys Phe Ala Leu Gly Asn Pro Val Pro Asp 
            260                 265                 270         


Ile Arg Trp Arg Lys Val Leu Glu Pro Met Pro Ser Thr Ala Glu Ile 
        275                 280                 285             


Ser Thr Ser Gly Ala Val Leu Lys Ile Phe Asn Ile Gln Leu Glu Asp 
    290                 295                 300                 


Glu Gly Ile Tyr Glu Cys Glu Ala Glu Asn Ile Arg Gly Lys Asp Lys 
305                 310                 315                 320 


His Gln Ala Arg Ile Tyr Val Gln Ala Phe Pro Glu Trp Val Glu His 
                325                 330                 335     


Ile Asn Asp Thr Glu Val Asp Ile Gly Ser Asp Leu Tyr Trp Pro Cys 
            340                 345                 350         


Val Ala Thr Gly Lys Pro Ile Pro Thr Ile Arg Trp Leu Lys Asn Gly 
        355                 360                 365             


Tyr Ala Tyr His Lys Gly Glu Leu Arg Leu Tyr Asp Val Thr Phe Glu 
    370                 375                 380                 


Asn Ala Gly Met Tyr Gln Cys Ile Ala Glu Asn Thr Tyr Gly Ala Ile 
385                 390                 395                 400 


Tyr Ala Asn Ala Glu Leu Lys Ile Leu Ala Leu Ala Pro Thr Phe Glu 
                405                 410                 415     


Met Asn Pro Met Lys Lys Lys Ile Leu Ala Ala Lys Gly Gly Arg Val 
            420                 425                 430         


Ile Ile Glu Cys Lys Pro Lys Ala Ala Pro Lys Pro Lys Phe Ser Trp 
        435                 440                 445             


Ser Lys Gly Thr Glu Trp Leu Val Asn Ser Ser Arg Ile Leu Ile Trp 
    450                 455                 460                 


Glu Asp Gly Ser Leu Glu Ile Asn Asn Ile Thr Arg Asn Asp Gly Gly 
465                 470                 475                 480 


Ile Tyr Thr Cys Phe Ala Glu Asn Asn Arg Gly Lys Ala Asn Ser Thr 
                485                 490                 495     


Gly Thr Leu Val Ile Thr Asp Pro Thr Arg Ile Ile Leu Ala Pro Ile 
            500                 505                 510         


Asn Ala Asp Ile Thr Val Gly Glu Asn Ala Thr Met Gln Cys Ala Ala 
        515                 520                 525             


Ser Phe Asp Pro Ala Leu Asp Leu Thr Phe Val Trp Ser Phe Asn Gly 
    530                 535                 540                 


Tyr Val Ile Asp Phe Asn Lys Glu Asn Ile His Tyr Gln Arg Asn Phe 
545                 550                 555                 560 


Met Leu Asp Ser Asn Gly Glu Leu Leu Ile Arg Asn Ala Gln Leu Lys 
                565                 570                 575     


His Ala Gly Arg Tyr Thr Cys Thr Ala Gln Thr Ile Val Asp Asn Ser 
            580                 585                 590         


Ser Ala Ser Ala Asp Leu Val Val Arg Gly Pro Pro Gly Pro Pro Gly 
        595                 600                 605             


Gly Leu Arg Ile Glu Asp Ile Arg Ala Thr Ser Val Ala Leu Thr Trp 
    610                 615                 620                 


Ser Arg Gly Ser Asp Asn His Ser Pro Ile Ser Lys Tyr Thr Ile Gln 
625                 630                 635                 640 


Thr Lys Thr Ile Leu Ser Asp Asp Trp Lys Asp Ala Lys Thr Asp Pro 
                645                 650                 655     


Pro Ile Ile Glu Gly Asn Met Glu Ala Ala Arg Ala Val Asp Leu Ile 
            660                 665                 670         


Pro Trp Met Glu Tyr Glu Phe Arg Val Val Ala Thr Asn Thr Leu Gly 
        675                 680                 685             


Arg Gly Glu Pro Ser Ile Pro Ser Asn Arg Ile Lys Thr Asp Gly Ala 
    690                 695                 700                 


Ala Pro Asn Val Ala Pro Ser Asp Val Gly Gly Gly Gly Gly Arg Asn 
705                 710                 715                 720 


Arg Glu Leu Thr Ile Thr Trp Ala Pro Leu Ser Arg Glu Tyr His Tyr 
                725                 730                 735     


Gly Asn Asn Phe Gly Tyr Ile Val Ala Phe Lys Pro Phe Asp Gly Glu 
            740                 745                 750         


Glu Trp Lys Lys Val Thr Val Thr Asn Pro Asp Thr Gly Arg Tyr Val 
        755                 760                 765             


His Lys Asp Glu Thr Met Ser Pro Ser Thr Ala Phe Gln Val Lys Val 
    770                 775                 780                 


Lys Ala Phe Asn Asn Lys Gly Asp Gly Pro Tyr Ser Leu Val Ala Val 
785                 790                 795                 800 


Ile Asn Ser Ala Gln Asp Ala Pro Ser Glu Ala Pro Thr Glu Val Gly 
                805                 810                 815     


Val Lys Val Leu Ser Ser Ser Glu Ile Ser Val His Trp Glu His Val 
            820                 825                 830         


Leu Glu Lys Ile Val Glu Ser Tyr Gln Ile Arg Tyr Trp Ala Ala His 
        835                 840                 845             


Asp Lys Glu Glu Ala Ala Asn Arg Val Gln Val Thr Ser Gln Glu Tyr 
    850                 855                 860                 


Ser Ala Arg Leu Glu Asn Leu Leu Pro Asp Thr Gln Tyr Phe Ile Glu 
865                 870                 875                 880 


Val Gly Ala Cys Asn Ser Ala Gly Cys Gly Pro Pro Ser Asp Met Ile 
                885                 890                 895     


Glu Ala Phe Thr Lys Lys Ala Pro Pro Ser Gln Pro Pro Arg Ile Ile 
            900                 905                 910         


Ser Ser Val Arg Ser Gly Ser Arg Tyr Ile Ile Thr Trp Asp His Val 
        915                 920                 925             


Val Ala Leu Ser Asn Glu Ser Thr Val Thr Gly Tyr Lys Val Leu Tyr 
    930                 935                 940                 


Arg Pro Asp Gly Gln His Asp Gly Lys Leu Tyr Ser Thr His Lys His 
945                 950                 955                 960 


Ser Ile Glu Val Pro Ile Pro Arg Asp Gly Glu Tyr Val Val Glu Val 
                965                 970                 975     


Arg Ala His Ser Asp Gly Gly Asp Gly Val Val Ser Gln Val Lys Ile 
            980                 985                 990         


Ser Gly Ala Pro Thr Leu Ser Pro  Ser Leu Leu Gly Leu  Leu Leu Pro 
        995                 1000                 1005             


Ala Phe  Gly Ile Leu Val Tyr  Leu Glu Phe 
    1010                 1015             


<210>  3128
<211>  627
<212>  PRT
<213>  Homo Sapiens

<400>  3128

Met Lys Met Trp Leu Leu Val Ser His Leu Val Ile Ile Ser Ile Thr 
1               5                   10                  15      


Thr Cys Leu Ala Glu Phe Thr Trp Tyr Arg Arg Tyr Gly His Gly Val 
            20                  25                  30          


Ser Glu Glu Asp Lys Gly Phe Gly Pro Ile Phe Glu Glu Gln Pro Ile 
        35                  40                  45              


Asn Thr Ile Tyr Pro Glu Glu Ser Leu Glu Gly Lys Val Ser Leu Asn 
    50                  55                  60                  


Cys Arg Ala Arg Ala Ser Pro Phe Pro Val Tyr Lys Trp Arg Met Asn 
65                  70                  75                  80  


Asn Gly Asp Val Asp Leu Thr Ser Asp Arg Tyr Ser Met Val Gly Gly 
                85                  90                  95      


Asn Leu Val Ile Asn Asn Pro Asp Lys Gln Lys Asp Ala Gly Ile Tyr 
            100                 105                 110         


Tyr Cys Leu Ala Ser Asn Asn Tyr Gly Met Val Arg Ser Thr Glu Ala 
        115                 120                 125             


Thr Leu Ser Phe Gly Tyr Leu Asp Pro Phe Pro Pro Glu Glu Arg Pro 
    130                 135                 140                 


Glu Val Arg Val Lys Glu Gly Lys Gly Met Val Leu Leu Cys Asp Pro 
145                 150                 155                 160 


Pro Tyr His Phe Pro Asp Asp Leu Ser Tyr Arg Trp Leu Leu Asn Glu 
                165                 170                 175     


Phe Pro Val Phe Ile Thr Met Asp Lys Arg Arg Phe Val Ser Gln Thr 
            180                 185                 190         


Asn Gly Asn Leu Tyr Ile Ala Asn Val Glu Ala Ser Asp Lys Gly Asn 
        195                 200                 205             


Tyr Ser Cys Phe Val Ser Ser Pro Ser Ile Thr Lys Ser Val Phe Ser 
    210                 215                 220                 


Lys Phe Ile Pro Leu Ile Pro Ile Pro Glu Arg Thr Thr Lys Pro Tyr 
225                 230                 235                 240 


Pro Ala Asp Ile Val Val Gln Phe Lys Asp Val Tyr Ala Leu Met Gly 
                245                 250                 255     


Gln Asn Val Thr Leu Glu Cys Phe Ala Leu Gly Asn Pro Val Pro Asp 
            260                 265                 270         


Ile Arg Trp Arg Lys Val Leu Glu Pro Met Pro Ser Thr Ala Glu Ile 
        275                 280                 285             


Ser Thr Ser Gly Ala Val Leu Lys Ile Phe Asn Ile Gln Leu Glu Asp 
    290                 295                 300                 


Glu Gly Ile Tyr Glu Cys Glu Ala Glu Asn Ile Arg Gly Lys Asp Lys 
305                 310                 315                 320 


His Gln Ala Arg Ile Tyr Val Gln Ala Phe Pro Glu Trp Val Glu His 
                325                 330                 335     


Ile Asn Asp Thr Glu Val Asp Ile Gly Ser Asp Leu Tyr Trp Pro Cys 
            340                 345                 350         


Val Ala Thr Gly Lys Pro Ile Pro Thr Ile Arg Trp Leu Lys Asn Gly 
        355                 360                 365             


Tyr Ala Tyr His Lys Gly Glu Leu Arg Leu Tyr Asp Val Thr Phe Glu 
    370                 375                 380                 


Asn Ala Gly Met Tyr Gln Cys Ile Ala Glu Asn Thr Tyr Gly Ala Ile 
385                 390                 395                 400 


Tyr Ala Asn Ala Glu Leu Lys Ile Leu Ala Leu Ala Pro Thr Phe Glu 
                405                 410                 415     


Met Asn Pro Met Lys Lys Lys Ile Leu Ala Ala Lys Gly Gly Arg Val 
            420                 425                 430         


Ile Ile Glu Cys Lys Pro Lys Ala Ala Pro Lys Pro Lys Phe Ser Trp 
        435                 440                 445             


Ser Lys Gly Thr Glu Trp Leu Val Asn Ser Ser Arg Ile Leu Ile Trp 
    450                 455                 460                 


Glu Asp Gly Ser Leu Glu Ile Asn Asn Ile Thr Arg Asn Asp Gly Gly 
465                 470                 475                 480 


Ile Tyr Thr Cys Phe Ala Glu Asn Asn Arg Gly Lys Ala Asn Ser Thr 
                485                 490                 495     


Gly Thr Leu Val Ile Thr Asp Pro Thr Arg Ile Ile Leu Ala Pro Ile 
            500                 505                 510         


Asn Ala Asp Ile Thr Val Gly Glu Asn Ala Thr Met Gln Cys Ala Ala 
        515                 520                 525             


Ser Phe Asp Pro Ala Leu Asp Leu Thr Phe Val Trp Ser Phe Asn Gly 
    530                 535                 540                 


Tyr Val Ile Asp Phe Asn Lys Glu Asn Ile His Tyr Gln Arg Asn Phe 
545                 550                 555                 560 


Met Leu Asp Ser Asn Gly Glu Leu Leu Ile Arg Asn Ala Gln Leu Lys 
                565                 570                 575     


His Ala Gly Arg Tyr Thr Cys Thr Ala Gln Thr Ile Val Asp Asn Ser 
            580                 585                 590         


Ser Ala Ser Ala Asp Leu Val Val Arg Gly Lys Asn Arg Lys Gly Gly 
        595                 600                 605             


Glu Lys Asn Met Val Asp Ser Phe Leu Pro Val Cys Ala Ser Leu Pro 
    610                 615                 620                 


Pro Thr Trp 
625         


<210>  3129
<211>  627
<212>  PRT
<213>  Homo Sapiens

<400>  3129

Met Lys Met Trp Leu Leu Val Ser His Leu Val Ile Ile Ser Ile Thr 
1               5                   10                  15      


Thr Cys Leu Ala Glu Phe Thr Trp Tyr Arg Arg Tyr Gly His Gly Val 
            20                  25                  30          


Ser Glu Glu Asp Lys Gly Phe Gly Pro Ile Phe Glu Glu Gln Pro Ile 
        35                  40                  45              


Asn Thr Ile Tyr Pro Glu Glu Ser Leu Glu Gly Lys Val Ser Leu Asn 
    50                  55                  60                  


Cys Arg Ala Arg Ala Ser Pro Phe Pro Val Tyr Lys Trp Arg Met Asn 
65                  70                  75                  80  


Asn Gly Asp Val Asp Leu Thr Ser Asp Arg Tyr Ser Met Val Gly Gly 
                85                  90                  95      


Asn Leu Val Ile Asn Asn Pro Asp Lys Gln Lys Asp Ala Gly Ile Tyr 
            100                 105                 110         


Tyr Cys Leu Ala Ser Asn Asn Tyr Gly Met Val Arg Ser Thr Glu Ala 
        115                 120                 125             


Thr Leu Ser Phe Gly Tyr Leu Asp Pro Phe Pro Pro Glu Glu Arg Pro 
    130                 135                 140                 


Glu Val Arg Val Lys Glu Gly Lys Gly Met Val Leu Leu Cys Asp Pro 
145                 150                 155                 160 


Pro Tyr His Phe Pro Asp Asp Leu Ser Tyr Arg Trp Leu Leu Asn Glu 
                165                 170                 175     


Phe Pro Val Phe Ile Thr Met Asp Lys Arg Arg Phe Val Ser Gln Thr 
            180                 185                 190         


Asn Gly Asn Leu Tyr Ile Ala Asn Val Glu Ala Ser Asp Lys Gly Asn 
        195                 200                 205             


Tyr Ser Cys Phe Val Ser Ser Pro Ser Ile Thr Lys Ser Val Phe Ser 
    210                 215                 220                 


Lys Phe Ile Pro Leu Ile Pro Ile Pro Glu Arg Thr Thr Lys Pro Tyr 
225                 230                 235                 240 


Pro Ala Asp Ile Val Val Gln Phe Lys Asp Val Tyr Ala Leu Met Gly 
                245                 250                 255     


Gln Asn Val Thr Leu Glu Cys Phe Ala Leu Gly Asn Pro Val Pro Asp 
            260                 265                 270         


Ile Arg Trp Arg Lys Val Leu Glu Pro Met Pro Ser Thr Ala Glu Ile 
        275                 280                 285             


Ser Thr Ser Gly Ala Val Leu Lys Ile Phe Asn Ile Gln Leu Glu Asp 
    290                 295                 300                 


Glu Gly Ile Tyr Glu Cys Glu Ala Glu Asn Ile Arg Gly Lys Asp Lys 
305                 310                 315                 320 


His Gln Ala Arg Ile Tyr Val Gln Ala Phe Pro Glu Trp Val Glu His 
                325                 330                 335     


Ile Asn Asp Thr Glu Val Asp Ile Gly Ser Asp Leu Tyr Trp Pro Cys 
            340                 345                 350         


Val Ala Thr Gly Lys Pro Ile Pro Thr Ile Arg Trp Leu Lys Asn Gly 
        355                 360                 365             


Tyr Ala Tyr His Lys Gly Glu Leu Arg Leu Tyr Asp Val Thr Phe Glu 
    370                 375                 380                 


Asn Ala Gly Met Tyr Gln Cys Ile Ala Glu Asn Thr Tyr Gly Ala Ile 
385                 390                 395                 400 


Tyr Ala Asn Ala Glu Leu Lys Ile Leu Ala Leu Ala Pro Thr Phe Glu 
                405                 410                 415     


Met Asn Pro Met Lys Lys Lys Ile Leu Ala Ala Lys Gly Gly Arg Val 
            420                 425                 430         


Ile Ile Glu Cys Lys Pro Lys Ala Ala Pro Lys Pro Lys Phe Ser Trp 
        435                 440                 445             


Ser Lys Gly Thr Glu Trp Leu Val Asn Ser Ser Arg Ile Leu Ile Trp 
    450                 455                 460                 


Glu Asp Gly Ser Leu Glu Ile Asn Asn Ile Thr Arg Asn Asp Gly Gly 
465                 470                 475                 480 


Ile Tyr Thr Cys Phe Ala Glu Asn Asn Arg Gly Lys Ala Asn Ser Thr 
                485                 490                 495     


Gly Thr Leu Val Ile Thr Asp Pro Thr Arg Ile Ile Leu Ala Pro Ile 
            500                 505                 510         


Asn Ala Asp Ile Thr Val Gly Glu Asn Ala Thr Met Gln Cys Ala Ala 
        515                 520                 525             


Ser Phe Asp Pro Ala Leu Asp Leu Thr Phe Val Trp Ser Phe Asn Gly 
    530                 535                 540                 


Tyr Val Ile Asp Phe Asn Lys Glu Asn Ile His Tyr Gln Arg Asn Phe 
545                 550                 555                 560 


Met Leu Asp Ser Asn Gly Glu Leu Leu Ile Arg Asn Ala Gln Leu Lys 
                565                 570                 575     


His Ala Gly Arg Tyr Thr Cys Thr Ala Gln Thr Ile Val Asp Asn Ser 
            580                 585                 590         


Ser Ala Ser Ala Asp Leu Val Val Arg Gly Lys Asn Arg Lys Gly Gly 
        595                 600                 605             


Glu Lys Asn Met Val Asp Ser Phe Leu Pro Val Cys Ala Ser Leu Pro 
    610                 615                 620                 


Pro Thr Trp 
625         


<210>  3130
<211>  1007
<212>  PRT
<213>  Homo Sapiens

<400>  3130

Met Lys Met Trp Leu Leu Val Ser His Leu Val Ile Ile Ser Ile Thr 
1               5                   10                  15      


Thr Cys Leu Ala Val Ser Glu Glu Asp Lys Gly Phe Gly Pro Ile Phe 
            20                  25                  30          


Glu Glu Gln Pro Ile Asn Thr Ile Tyr Pro Glu Glu Ser Leu Glu Gly 
        35                  40                  45              


Lys Val Ser Leu Asn Cys Arg Ala Arg Ala Ser Pro Phe Pro Val Tyr 
    50                  55                  60                  


Lys Trp Arg Met Asn Asn Gly Asp Val Asp Leu Thr Ser Asp Arg Tyr 
65                  70                  75                  80  


Ser Met Val Gly Gly Asn Leu Val Ile Asn Asn Pro Asp Lys Gln Lys 
                85                  90                  95      


Asp Ala Gly Ile Tyr Tyr Cys Leu Ala Ser Asn Asn Tyr Gly Met Val 
            100                 105                 110         


Arg Ser Thr Glu Ala Thr Leu Ser Phe Gly Tyr Leu Asp Pro Phe Pro 
        115                 120                 125             


Pro Glu Glu Arg Pro Glu Val Arg Val Lys Glu Gly Lys Gly Met Val 
    130                 135                 140                 


Leu Leu Cys Asp Pro Pro Tyr His Phe Pro Asp Asp Leu Ser Tyr Arg 
145                 150                 155                 160 


Trp Leu Leu Asn Glu Phe Pro Val Phe Ile Thr Met Asp Lys Arg Arg 
                165                 170                 175     


Phe Val Ser Gln Thr Asn Gly Asn Leu Tyr Ile Ala Asn Val Glu Ala 
            180                 185                 190         


Ser Asp Lys Gly Asn Tyr Ser Cys Phe Val Ser Ser Pro Ser Ile Thr 
        195                 200                 205             


Lys Ser Val Phe Ser Lys Phe Ile Pro Leu Ile Pro Ile Pro Glu Arg 
    210                 215                 220                 


Thr Thr Lys Pro Tyr Pro Ala Asp Ile Val Val Gln Phe Lys Asp Val 
225                 230                 235                 240 


Tyr Ala Leu Met Gly Gln Asn Val Thr Leu Glu Cys Phe Ala Leu Gly 
                245                 250                 255     


Asn Pro Val Pro Asp Ile Arg Trp Arg Lys Val Leu Glu Pro Met Pro 
            260                 265                 270         


Ser Thr Ala Glu Ile Ser Thr Ser Gly Ala Val Leu Lys Ile Phe Asn 
        275                 280                 285             


Ile Gln Leu Glu Asp Glu Gly Ile Tyr Glu Cys Glu Ala Glu Asn Ile 
    290                 295                 300                 


Arg Gly Lys Asp Lys His Gln Ala Arg Ile Tyr Val Gln Ala Phe Pro 
305                 310                 315                 320 


Glu Trp Val Glu His Ile Asn Asp Thr Glu Val Asp Ile Gly Ser Asp 
                325                 330                 335     


Leu Tyr Trp Pro Cys Val Ala Thr Gly Lys Pro Ile Pro Thr Ile Arg 
            340                 345                 350         


Trp Leu Lys Asn Gly Tyr Ala Tyr His Lys Gly Glu Leu Arg Leu Tyr 
        355                 360                 365             


Asp Val Thr Phe Glu Asn Ala Gly Met Tyr Gln Cys Ile Ala Glu Asn 
    370                 375                 380                 


Thr Tyr Gly Ala Ile Tyr Ala Asn Ala Glu Leu Lys Ile Leu Ala Leu 
385                 390                 395                 400 


Ala Pro Thr Phe Glu Met Asn Pro Met Lys Lys Lys Ile Leu Ala Ala 
                405                 410                 415     


Lys Gly Gly Arg Val Ile Ile Glu Cys Lys Pro Lys Ala Ala Pro Lys 
            420                 425                 430         


Pro Lys Phe Ser Trp Ser Lys Gly Thr Glu Trp Leu Val Asn Ser Ser 
        435                 440                 445             


Arg Ile Leu Ile Trp Glu Asp Gly Ser Leu Glu Ile Asn Asn Ile Thr 
    450                 455                 460                 


Arg Asn Asp Gly Gly Ile Tyr Thr Cys Phe Ala Glu Asn Asn Arg Gly 
465                 470                 475                 480 


Lys Ala Asn Ser Thr Gly Thr Leu Val Ile Thr Asp Pro Thr Arg Ile 
                485                 490                 495     


Ile Leu Ala Pro Ile Asn Ala Asp Ile Thr Val Gly Glu Asn Ala Thr 
            500                 505                 510         


Met Gln Cys Ala Ala Ser Phe Asp Pro Ala Leu Asp Leu Thr Phe Val 
        515                 520                 525             


Trp Ser Phe Asn Gly Tyr Val Ile Asp Phe Asn Lys Glu Asn Ile His 
    530                 535                 540                 


Tyr Gln Arg Asn Phe Met Leu Asp Ser Asn Gly Glu Leu Leu Ile Arg 
545                 550                 555                 560 


Asn Ala Gln Leu Lys His Ala Gly Arg Tyr Thr Cys Thr Ala Gln Thr 
                565                 570                 575     


Ile Val Asp Asn Ser Ser Ala Ser Ala Asp Leu Val Val Arg Gly Pro 
            580                 585                 590         


Pro Gly Pro Pro Gly Gly Leu Arg Ile Glu Asp Ile Arg Ala Thr Ser 
        595                 600                 605             


Val Ala Leu Thr Trp Ser Arg Gly Ser Asp Asn His Ser Pro Ile Ser 
    610                 615                 620                 


Lys Tyr Thr Ile Gln Thr Lys Thr Ile Leu Ser Asp Asp Trp Lys Asp 
625                 630                 635                 640 


Ala Lys Thr Asp Pro Pro Ile Ile Glu Gly Asn Met Glu Ala Ala Arg 
                645                 650                 655     


Ala Val Asp Leu Ile Pro Trp Met Glu Tyr Glu Phe Arg Val Val Ala 
            660                 665                 670         


Thr Asn Thr Leu Gly Arg Gly Glu Pro Ser Ile Pro Ser Asn Arg Ile 
        675                 680                 685             


Lys Thr Asp Gly Ala Ala Pro Asn Val Ala Pro Ser Asp Val Gly Gly 
    690                 695                 700                 


Gly Gly Gly Arg Asn Arg Glu Leu Thr Ile Thr Trp Ala Pro Leu Ser 
705                 710                 715                 720 


Arg Glu Tyr His Tyr Gly Asn Asn Phe Gly Tyr Ile Val Ala Phe Lys 
                725                 730                 735     


Pro Phe Asp Gly Glu Glu Trp Lys Lys Val Thr Val Thr Asn Pro Asp 
            740                 745                 750         


Thr Gly Arg Tyr Val His Lys Asp Glu Thr Met Ser Pro Ser Thr Ala 
        755                 760                 765             


Phe Gln Val Lys Val Lys Ala Phe Asn Asn Lys Gly Asp Gly Pro Tyr 
    770                 775                 780                 


Ser Leu Val Ala Val Ile Asn Ser Ala Gln Asp Ala Pro Ser Glu Ala 
785                 790                 795                 800 


Pro Thr Glu Val Gly Val Lys Val Leu Ser Ser Ser Glu Ile Ser Val 
                805                 810                 815     


His Trp Glu His Val Leu Glu Lys Ile Val Glu Ser Tyr Gln Ile Arg 
            820                 825                 830         


Tyr Trp Ala Ala His Asp Lys Glu Glu Ala Ala Asn Arg Val Gln Val 
        835                 840                 845             


Thr Ser Gln Glu Tyr Ser Ala Arg Leu Glu Asn Leu Leu Pro Asp Thr 
    850                 855                 860                 


Gln Tyr Phe Ile Glu Val Gly Ala Cys Asn Ser Ala Gly Cys Gly Pro 
865                 870                 875                 880 


Pro Ser Asp Met Ile Glu Ala Phe Thr Lys Lys Ala Pro Pro Ser Gln 
                885                 890                 895     


Pro Pro Arg Ile Ile Ser Ser Val Arg Ser Gly Ser Arg Tyr Ile Ile 
            900                 905                 910         


Thr Trp Asp His Val Val Ala Leu Ser Asn Glu Ser Thr Val Thr Gly 
        915                 920                 925             


Tyr Lys Val Leu Tyr Arg Pro Asp Gly Gln His Asp Gly Lys Leu Tyr 
    930                 935                 940                 


Ser Thr His Lys His Ser Ile Glu Val Pro Ile Pro Arg Asp Gly Glu 
945                 950                 955                 960 


Tyr Val Val Glu Val Arg Ala His Ser Asp Gly Gly Asp Gly Val Val 
                965                 970                 975     


Ser Gln Val Lys Ile Ser Gly Ala Pro Thr Leu Ser Pro Ser Leu Leu 
            980                 985                 990         


Gly Leu Leu Leu Pro Ala Phe Gly  Ile Leu Val Tyr Leu  Glu Phe 
        995                 1000                 1005         


<210>  3131
<211>  1040
<212>  PRT
<213>  Homo Sapiens

<400>  3131

Met Gly Thr Ala Thr Arg Arg Lys Pro His Leu Leu Leu Val Ala Ala 
1               5                   10                  15      


Val Ala Leu Val Ser Ser Ser Ala Trp Ser Ser Ala Leu Gly Ser Gln 
            20                  25                  30          


Thr Thr Phe Gly Pro Val Phe Glu Asp Gln Pro Leu Ser Val Leu Phe 
        35                  40                  45              


Pro Glu Glu Ser Thr Glu Glu Gln Val Leu Leu Ala Cys Arg Ala Arg 
    50                  55                  60                  


Ala Ser Pro Pro Ala Thr Tyr Arg Trp Lys Met Asn Gly Thr Glu Met 
65                  70                  75                  80  


Lys Leu Glu Pro Gly Ser Arg His Gln Leu Val Gly Gly Asn Leu Val 
                85                  90                  95      


Ile Met Asn Pro Thr Lys Ala Gln Asp Ala Gly Val Tyr Gln Cys Leu 
            100                 105                 110         


Ala Ser Asn Pro Val Gly Thr Val Val Ser Arg Glu Ala Ile Leu Arg 
        115                 120                 125             


Phe Gly Phe Leu Gln Glu Phe Ser Lys Glu Glu Arg Asp Pro Val Lys 
    130                 135                 140                 


Ala His Glu Gly Trp Gly Val Met Leu Pro Cys Asn Pro Pro Ala His 
145                 150                 155                 160 


Tyr Pro Gly Leu Ser Tyr Arg Trp Leu Leu Asn Glu Phe Pro Asn Phe 
                165                 170                 175     


Ile Pro Thr Asp Gly Arg His Phe Val Ser Gln Thr Thr Gly Asn Leu 
            180                 185                 190         


Tyr Ile Ala Arg Thr Asn Ala Ser Asp Leu Gly Asn Tyr Ser Cys Leu 
        195                 200                 205             


Ala Thr Ser His Met Asp Phe Ser Thr Lys Ser Val Phe Ser Lys Phe 
    210                 215                 220                 


Ala Gln Leu Asn Leu Ala Ala Glu Asp Thr Arg Leu Phe Ala Pro Ser 
225                 230                 235                 240 


Ile Lys Ala Arg Phe Pro Ala Glu Thr Tyr Ala Leu Val Gly Gln Gln 
                245                 250                 255     


Val Thr Leu Glu Cys Phe Ala Phe Gly Asn Pro Val Pro Arg Ile Lys 
            260                 265                 270         


Trp Arg Lys Val Asp Gly Ser Leu Ser Pro Gln Trp Thr Thr Ala Glu 
        275                 280                 285             


Pro Thr Leu Gln Ile Pro Ser Val Ser Phe Glu Asp Glu Gly Thr Tyr 
    290                 295                 300                 


Glu Cys Glu Ala Glu Asn Ser Lys Gly Arg Asp Thr Val Gln Gly Arg 
305                 310                 315                 320 


Ile Ile Val Gln Ala Gln Pro Glu Trp Leu Lys Val Ile Ser Asp Thr 
                325                 330                 335     


Glu Ala Asp Ile Gly Ser Asn Leu Arg Trp Gly Cys Ala Ala Ala Gly 
            340                 345                 350         


Lys Pro Arg Pro Thr Val Arg Trp Leu Arg Asn Gly Glu Pro Leu Ala 
        355                 360                 365             


Ser Gln Asn Arg Val Glu Val Leu Ala Gly Asp Leu Arg Phe Ser Lys 
    370                 375                 380                 


Leu Ser Leu Glu Asp Ser Gly Met Tyr Gln Cys Val Ala Glu Asn Lys 
385                 390                 395                 400 


His Gly Thr Ile Tyr Ala Ser Ala Glu Leu Ala Val Gln Ala Leu Ala 
                405                 410                 415     


Pro Asp Phe Arg Leu Asn Pro Val Arg Arg Leu Ile Pro Ala Ala Arg 
            420                 425                 430         


Gly Gly Glu Ile Leu Ile Pro Cys Gln Pro Arg Ala Ala Pro Lys Ala 
        435                 440                 445             


Val Val Leu Trp Ser Lys Gly Thr Glu Ile Leu Val Asn Ser Ser Arg 
    450                 455                 460                 


Val Thr Val Thr Pro Asp Gly Thr Leu Ile Ile Arg Asn Ile Ser Arg 
465                 470                 475                 480 


Ser Asp Glu Gly Lys Tyr Thr Cys Phe Ala Glu Asn Phe Met Gly Lys 
                485                 490                 495     


Ala Asn Ser Thr Gly Ile Leu Ser Val Arg Asp Ala Thr Lys Ile Thr 
            500                 505                 510         


Leu Ala Pro Ser Ser Ala Asp Ile Asn Leu Gly Asp Asn Leu Thr Leu 
        515                 520                 525             


Gln Cys His Ala Ser His Asp Pro Thr Met Asp Leu Thr Phe Thr Trp 
    530                 535                 540                 


Thr Leu Asp Asp Phe Pro Ile Asp Phe Asp Lys Pro Gly Gly His Tyr 
545                 550                 555                 560 


Arg Arg Thr Asn Val Lys Glu Thr Ile Gly Asp Leu Thr Ile Leu Asn 
                565                 570                 575     


Ala Gln Leu Arg His Gly Gly Lys Tyr Thr Cys Met Ala Gln Thr Val 
            580                 585                 590         


Val Asp Ser Ala Ser Lys Glu Ala Thr Val Leu Val Arg Gly Pro Pro 
        595                 600                 605             


Gly Pro Pro Gly Gly Val Val Val Arg Asp Ile Gly Asp Thr Thr Ile 
    610                 615                 620                 


Gln Leu Ser Trp Ser Arg Gly Phe Asp Asn His Ser Pro Ile Ala Lys 
625                 630                 635                 640 


Tyr Thr Leu Gln Ala Arg Thr Pro Pro Ala Gly Lys Trp Lys Gln Val 
                645                 650                 655     


Arg Thr Asn Pro Ala Asn Ile Glu Gly Asn Ala Glu Thr Ala Gln Val 
            660                 665                 670         


Leu Gly Leu Thr Pro Trp Met Asp Tyr Glu Phe Arg Val Ile Ala Ser 
        675                 680                 685             


Asn Ile Leu Gly Thr Gly Glu Pro Ser Gly Pro Ser Ser Lys Ile Arg 
    690                 695                 700                 


Thr Arg Glu Ala Ala Pro Ser Val Ala Pro Ser Gly Leu Ser Gly Gly 
705                 710                 715                 720 


Gly Gly Ala Pro Gly Glu Leu Ile Val Asn Trp Thr Pro Met Ser Arg 
                725                 730                 735     


Glu Tyr Gln Asn Gly Asp Gly Phe Gly Tyr Leu Leu Ser Phe Arg Arg 
            740                 745                 750         


Gln Gly Ser Thr His Trp Gln Thr Ala Arg Val Pro Gly Ala Asp Ala 
        755                 760                 765             


Gln Tyr Phe Val Tyr Ser Asn Glu Ser Val Arg Pro Tyr Thr Pro Phe 
    770                 775                 780                 


Glu Val Lys Ile Arg Ser Tyr Asn Arg Arg Gly Asp Gly Pro Glu Ser 
785                 790                 795                 800 


Leu Thr Ala Leu Val Tyr Ser Ala Glu Glu Glu Pro Arg Val Ala Pro 
                805                 810                 815     


Thr Lys Val Trp Ala Lys Gly Val Ser Ser Ser Glu Met Asn Val Thr 
            820                 825                 830         


Trp Glu Pro Val Gln Gln Asp Met Asn Gly Ile Leu Leu Gly Tyr Glu 
        835                 840                 845             


Ile Arg Tyr Trp Lys Ala Gly Asp Lys Glu Ala Ala Ala Asp Arg Val 
    850                 855                 860                 


Arg Thr Ala Gly Leu Asp Thr Ser Ala Arg Val Ser Gly Leu His Pro 
865                 870                 875                 880 


Asn Thr Lys Tyr His Val Thr Val Arg Ala Tyr Asn Arg Ala Gly Thr 
                885                 890                 895     


Gly Pro Ala Ser Pro Ser Ala Asn Ala Thr Thr Met Lys Pro Pro Pro 
            900                 905                 910         


Arg Arg Pro Pro Gly Asn Ile Ser Trp Thr Phe Ser Ser Ser Ser Leu 
        915                 920                 925             


Ser Ile Lys Trp Asp Pro Val Val Pro Phe Arg Asn Glu Ser Ala Val 
    930                 935                 940                 


Thr Gly Tyr Lys Met Leu Tyr Gln Asn Asp Leu His Leu Thr Pro Thr 
945                 950                 955                 960 


Leu His Leu Thr Gly Lys Asn Trp Ile Glu Ile Pro Val Pro Glu Asp 
                965                 970                 975     


Ile Gly His Ala Leu Val Gln Ile Arg Thr Thr Gly Pro Gly Gly Asp 
            980                 985                 990         


Gly Ile Pro Ala Glu Val His Ile  Val Arg Asn Gly Gly  Thr Ser Met 
        995                 1000                 1005             


Met Val  Glu Asn Met Ala Val  Arg Pro Ala Pro His  Pro Gly Thr 
    1010                 1015                 1020             


Val Ile  Ser His Ser Val Ala  Met Leu Ile Leu Ile  Gly Ser Leu 
    1025                 1030                 1035             


Glu Leu  
    1040 


<210>  3132
<211>  1040
<212>  PRT
<213>  Homo Sapiens

<400>  3132

Met Gly Thr Ala Thr Arg Arg Lys Pro His Leu Leu Leu Val Ala Ala 
1               5                   10                  15      


Val Ala Leu Val Ser Ser Ser Ala Trp Ser Ser Ala Leu Gly Ser Gln 
            20                  25                  30          


Thr Thr Phe Gly Pro Val Phe Glu Asp Gln Pro Leu Ser Val Leu Phe 
        35                  40                  45              


Pro Glu Glu Ser Thr Glu Glu Gln Val Leu Leu Ala Cys Arg Ala Arg 
    50                  55                  60                  


Ala Ser Pro Pro Ala Thr Tyr Arg Trp Lys Met Asn Gly Thr Glu Met 
65                  70                  75                  80  


Lys Leu Glu Pro Gly Ser Arg His Gln Leu Val Gly Gly Asn Leu Val 
                85                  90                  95      


Ile Met Asn Pro Thr Lys Ala Gln Asp Ala Gly Val Tyr Gln Cys Leu 
            100                 105                 110         


Ala Ser Asn Pro Val Gly Thr Val Val Ser Arg Glu Ala Ile Leu Arg 
        115                 120                 125             


Phe Gly Phe Leu Gln Glu Phe Ser Lys Glu Glu Arg Asp Pro Val Lys 
    130                 135                 140                 


Ala His Glu Gly Trp Gly Val Met Leu Pro Cys Asn Pro Pro Ala His 
145                 150                 155                 160 


Tyr Pro Gly Leu Ser Tyr Arg Trp Leu Leu Asn Glu Phe Pro Asn Phe 
                165                 170                 175     


Ile Pro Thr Asp Gly Arg His Phe Val Ser Gln Thr Thr Gly Asn Leu 
            180                 185                 190         


Tyr Ile Ala Arg Thr Asn Ala Ser Asp Leu Gly Asn Tyr Ser Cys Leu 
        195                 200                 205             


Ala Thr Ser His Met Asp Phe Ser Thr Lys Ser Val Phe Ser Lys Phe 
    210                 215                 220                 


Ala Gln Leu Asn Leu Ala Ala Glu Asp Thr Arg Leu Phe Ala Pro Ser 
225                 230                 235                 240 


Ile Lys Ala Arg Phe Pro Ala Glu Thr Tyr Ala Leu Val Gly Gln Gln 
                245                 250                 255     


Val Thr Leu Glu Cys Phe Ala Phe Gly Asn Pro Val Pro Arg Ile Lys 
            260                 265                 270         


Trp Arg Lys Val Asp Gly Ser Leu Ser Pro Gln Trp Thr Thr Ala Glu 
        275                 280                 285             


Pro Thr Leu Gln Ile Pro Ser Val Ser Phe Glu Asp Glu Gly Thr Tyr 
    290                 295                 300                 


Glu Cys Glu Ala Glu Asn Ser Lys Gly Arg Asp Thr Val Gln Gly Arg 
305                 310                 315                 320 


Ile Ile Val Gln Ala Gln Pro Glu Trp Leu Lys Val Ile Ser Asp Thr 
                325                 330                 335     


Glu Ala Asp Ile Gly Ser Asn Leu Arg Trp Gly Cys Ala Ala Ala Gly 
            340                 345                 350         


Lys Pro Arg Pro Thr Val Arg Trp Leu Arg Asn Gly Glu Pro Leu Ala 
        355                 360                 365             


Ser Gln Asn Arg Val Glu Val Leu Ala Gly Asp Leu Arg Phe Ser Lys 
    370                 375                 380                 


Leu Ser Leu Glu Asp Ser Gly Met Tyr Gln Cys Val Ala Glu Asn Lys 
385                 390                 395                 400 


His Gly Thr Ile Tyr Ala Ser Ala Glu Leu Ala Val Gln Ala Leu Ala 
                405                 410                 415     


Pro Asp Phe Arg Leu Asn Pro Val Arg Arg Leu Ile Pro Ala Ala Arg 
            420                 425                 430         


Gly Gly Glu Ile Leu Ile Pro Cys Gln Pro Arg Ala Ala Pro Lys Ala 
        435                 440                 445             


Val Val Leu Trp Ser Lys Gly Thr Glu Ile Leu Val Asn Ser Ser Arg 
    450                 455                 460                 


Val Thr Val Thr Pro Asp Gly Thr Leu Ile Ile Arg Asn Ile Ser Arg 
465                 470                 475                 480 


Ser Asp Glu Gly Lys Tyr Thr Cys Phe Ala Glu Asn Phe Met Gly Lys 
                485                 490                 495     


Ala Asn Ser Thr Gly Ile Leu Ser Val Arg Asp Ala Thr Lys Ile Thr 
            500                 505                 510         


Leu Ala Pro Ser Ser Ala Asp Ile Asn Leu Gly Asp Asn Leu Thr Leu 
        515                 520                 525             


Gln Cys His Ala Ser His Asp Pro Thr Met Asp Leu Thr Phe Thr Trp 
    530                 535                 540                 


Thr Leu Asp Asp Phe Pro Ile Asp Phe Asp Lys Pro Gly Gly His Tyr 
545                 550                 555                 560 


Arg Arg Thr Asn Val Lys Glu Thr Ile Gly Asp Leu Thr Ile Leu Asn 
                565                 570                 575     


Ala Gln Leu Arg His Gly Gly Lys Tyr Thr Cys Met Ala Gln Thr Val 
            580                 585                 590         


Val Asp Ser Ala Ser Lys Glu Ala Thr Val Leu Val Arg Gly Pro Pro 
        595                 600                 605             


Gly Pro Pro Gly Gly Val Val Val Arg Asp Ile Gly Asp Thr Thr Ile 
    610                 615                 620                 


Gln Leu Ser Trp Ser Arg Gly Phe Asp Asn His Ser Pro Ile Ala Lys 
625                 630                 635                 640 


Tyr Thr Leu Gln Ala Arg Thr Pro Pro Ala Gly Lys Trp Lys Gln Val 
                645                 650                 655     


Arg Thr Asn Pro Ala Asn Ile Glu Gly Asn Ala Glu Thr Ala Gln Val 
            660                 665                 670         


Leu Gly Leu Thr Pro Trp Met Asp Tyr Glu Phe Arg Val Ile Ala Ser 
        675                 680                 685             


Asn Ile Leu Gly Thr Gly Glu Pro Ser Gly Pro Ser Ser Lys Ile Arg 
    690                 695                 700                 


Thr Arg Glu Ala Ala Pro Ser Val Ala Pro Ser Gly Leu Ser Gly Gly 
705                 710                 715                 720 


Gly Gly Ala Pro Gly Glu Leu Ile Val Asn Trp Thr Pro Met Ser Arg 
                725                 730                 735     


Glu Tyr Gln Asn Gly Asp Gly Phe Gly Tyr Leu Leu Ser Phe Arg Arg 
            740                 745                 750         


Gln Gly Ser Thr His Trp Gln Thr Ala Arg Val Pro Gly Ala Asp Ala 
        755                 760                 765             


Gln Tyr Phe Val Tyr Ser Asn Glu Ser Val Arg Pro Tyr Thr Pro Phe 
    770                 775                 780                 


Glu Val Lys Ile Arg Ser Tyr Asn Arg Arg Gly Asp Gly Pro Glu Ser 
785                 790                 795                 800 


Leu Thr Ala Leu Val Tyr Ser Ala Glu Glu Glu Pro Arg Val Ala Pro 
                805                 810                 815     


Thr Lys Val Trp Ala Lys Gly Val Ser Ser Ser Glu Met Asn Val Thr 
            820                 825                 830         


Trp Glu Pro Val Gln Gln Asp Met Asn Gly Ile Leu Leu Gly Tyr Glu 
        835                 840                 845             


Ile Arg Tyr Trp Lys Ala Gly Asp Lys Glu Ala Ala Ala Asp Arg Val 
    850                 855                 860                 


Arg Thr Ala Gly Leu Asp Thr Ser Ala Arg Val Ser Gly Leu His Pro 
865                 870                 875                 880 


Asn Thr Lys Tyr His Val Thr Val Arg Ala Tyr Asn Arg Ala Gly Thr 
                885                 890                 895     


Gly Pro Ala Ser Pro Ser Ala Asn Ala Thr Thr Met Lys Pro Pro Pro 
            900                 905                 910         


Arg Arg Pro Pro Gly Asn Ile Ser Trp Thr Phe Ser Ser Ser Ser Leu 
        915                 920                 925             


Ser Ile Lys Trp Asp Pro Val Val Pro Phe Arg Asn Glu Ser Ala Val 
    930                 935                 940                 


Thr Gly Tyr Lys Met Leu Tyr Gln Asn Asp Leu His Leu Thr Pro Thr 
945                 950                 955                 960 


Leu His Leu Thr Gly Lys Asn Trp Ile Glu Ile Pro Val Pro Glu Asp 
                965                 970                 975     


Ile Gly His Ala Leu Val Gln Ile Arg Thr Thr Gly Pro Gly Gly Asp 
            980                 985                 990         


Gly Ile Pro Ala Glu Val His Ile  Val Arg Asn Gly Gly  Thr Ser Met 
        995                 1000                 1005             


Met Val  Glu Asn Met Ala Val  Arg Pro Ala Pro His  Pro Gly Thr 
    1010                 1015                 1020             


Val Ile  Ser His Ser Val Ala  Met Leu Ile Leu Ile  Gly Ser Leu 
    1025                 1030                 1035             


Glu Leu  
    1040 


<210>  3133
<211>  1085
<212>  PRT
<213>  Homo Sapiens

<400>  3133

Met Gly Thr Ala Thr Arg Arg Lys Pro His Leu Leu Leu Val Ala Ala 
1               5                   10                  15      


Val Ala Leu Val Ser Ser Ser Ala Trp Ser Ser Ala Leu Gly Ser Gln 
            20                  25                  30          


Thr Thr Phe Gly Pro Val Phe Glu Asp Gln Pro Leu Ser Val Leu Phe 
        35                  40                  45              


Pro Glu Glu Ser Thr Glu Glu Gln Val Leu Leu Ala Cys Arg Ala Arg 
    50                  55                  60                  


Ala Ser Pro Pro Ala Thr Tyr Arg Trp Lys Met Asn Gly Thr Glu Met 
65                  70                  75                  80  


Lys Leu Glu Pro Gly Ser Arg His Gln Leu Val Gly Gly Asn Leu Val 
                85                  90                  95      


Ile Met Asn Pro Thr Lys Ala Gln Asp Ala Gly Val Tyr Gln Cys Leu 
            100                 105                 110         


Ala Ser Asn Pro Val Gly Thr Val Val Ser Arg Glu Ala Ile Leu Arg 
        115                 120                 125             


Phe Gly Phe Leu Gln Glu Phe Ser Lys Glu Glu Arg Asp Pro Val Lys 
    130                 135                 140                 


Ala His Glu Gly Trp Gly Val Met Leu Pro Cys Asn Pro Pro Ala His 
145                 150                 155                 160 


Tyr Pro Gly Leu Ser Tyr Arg Trp Leu Leu Asn Glu Phe Pro Asn Phe 
                165                 170                 175     


Ile Pro Thr Asp Gly Arg His Phe Val Ser Gln Thr Thr Gly Asn Leu 
            180                 185                 190         


Tyr Ile Ala Arg Thr Asn Ala Ser Asp Leu Gly Asn Tyr Ser Cys Leu 
        195                 200                 205             


Ala Thr Ser His Met Asp Phe Ser Thr Lys Ser Val Phe Ser Lys Phe 
    210                 215                 220                 


Ala Gln Leu Asn Leu Ala Ala Glu Asp Thr Arg Leu Phe Ala Pro Ser 
225                 230                 235                 240 


Ile Lys Ala Arg Phe Pro Ala Glu Thr Tyr Ala Leu Val Gly Gln Gln 
                245                 250                 255     


Val Thr Leu Glu Cys Phe Ala Phe Gly Asn Pro Val Pro Arg Ile Lys 
            260                 265                 270         


Trp Arg Lys Val Asp Gly Ser Leu Ser Pro Gln Trp Thr Thr Ala Glu 
        275                 280                 285             


Pro Thr Leu Gln Ile Pro Ser Val Ser Phe Glu Asp Glu Gly Thr Tyr 
    290                 295                 300                 


Glu Cys Glu Ala Glu Asn Ser Lys Gly Arg Asp Thr Val Gln Gly Arg 
305                 310                 315                 320 


Ile Ile Val Gln Ala Gln Pro Glu Trp Leu Lys Val Ile Ser Asp Thr 
                325                 330                 335     


Glu Ala Asp Ile Gly Ser Asn Leu Arg Trp Gly Cys Ala Ala Ala Gly 
            340                 345                 350         


Lys Pro Arg Pro Thr Val Arg Trp Leu Arg Asn Gly Glu Pro Leu Ala 
        355                 360                 365             


Ser Gln Asn Arg Val Glu Val Leu Ala Gly Asp Leu Arg Phe Ser Lys 
    370                 375                 380                 


Leu Ser Leu Glu Asp Ser Gly Met Tyr Gln Cys Val Ala Glu Asn Lys 
385                 390                 395                 400 


His Gly Thr Ile Tyr Ala Ser Ala Glu Leu Ala Val Gln Ala Leu Ala 
                405                 410                 415     


Pro Asp Phe Arg Leu Asn Pro Val Arg Arg Leu Ile Pro Ala Ala Arg 
            420                 425                 430         


Gly Gly Glu Ile Leu Ile Pro Cys Gln Pro Arg Ala Ala Pro Lys Ala 
        435                 440                 445             


Val Val Leu Trp Ser Lys Gly Thr Glu Ile Leu Val Asn Ser Ser Arg 
    450                 455                 460                 


Val Thr Val Thr Pro Asp Gly Thr Leu Ile Ile Arg Asn Ile Ser Arg 
465                 470                 475                 480 


Ser Asp Glu Gly Lys Tyr Thr Cys Phe Ala Glu Asn Phe Met Gly Lys 
                485                 490                 495     


Ala Asn Ser Thr Gly Ile Leu Ser Val Arg Asp Ala Thr Lys Ile Thr 
            500                 505                 510         


Leu Ala Pro Ser Ser Ala Asp Ile Asn Leu Gly Asp Asn Leu Thr Leu 
        515                 520                 525             


Gln Cys His Ala Ser His Asp Pro Thr Met Asp Leu Thr Phe Thr Trp 
    530                 535                 540                 


Thr Leu Asp Asp Phe Pro Ile Asp Phe Asp Lys Pro Gly Gly His Tyr 
545                 550                 555                 560 


Arg Arg Thr Asn Val Lys Glu Thr Ile Gly Asp Leu Thr Ile Leu Asn 
                565                 570                 575     


Ala Gln Leu Arg His Gly Gly Lys Tyr Thr Cys Met Ala Gln Thr Val 
            580                 585                 590         


Val Asp Ser Ala Ser Lys Glu Ala Thr Val Leu Val Arg Gly Pro Pro 
        595                 600                 605             


Gly Pro Pro Gly Gly Val Val Val Arg Asp Ile Gly Asp Thr Thr Ile 
    610                 615                 620                 


Gln Leu Ser Trp Ser Arg Gly Phe Asp Asn His Ser Pro Ile Ala Lys 
625                 630                 635                 640 


Tyr Thr Leu Gln Ala Arg Thr Pro Pro Ala Gly Lys Trp Lys Gln Val 
                645                 650                 655     


Arg Thr Asn Pro Ala Asn Ile Glu Gly Asn Ala Glu Thr Ala Gln Val 
            660                 665                 670         


Leu Gly Leu Thr Pro Trp Met Asp Tyr Glu Phe Arg Val Ile Ala Ser 
        675                 680                 685             


Asn Ile Leu Gly Thr Gly Glu Pro Ser Gly Pro Ser Ser Lys Ile Arg 
    690                 695                 700                 


Thr Arg Glu Ala Ala Pro Ser Val Ala Pro Ser Gly Leu Ser Gly Gly 
705                 710                 715                 720 


Gly Gly Ala Pro Gly Glu Leu Ile Val Asn Trp Thr Pro Met Ser Arg 
                725                 730                 735     


Glu Tyr Gln Asn Gly Asp Gly Phe Gly Tyr Leu Leu Ser Phe Arg Arg 
            740                 745                 750         


Gln Gly Ser Thr His Trp Gln Thr Ala Arg Val Pro Gly Ala Asp Ala 
        755                 760                 765             


Gln Tyr Phe Val Tyr Ser Asn Glu Ser Val Arg Pro Tyr Thr Pro Phe 
    770                 775                 780                 


Glu Val Lys Ile Arg Ser Tyr Asn Arg Arg Gly Asp Gly Pro Glu Ser 
785                 790                 795                 800 


Leu Thr Ala Leu Val Tyr Ser Ala Glu Glu Glu Pro Arg Val Ala Pro 
                805                 810                 815     


Thr Lys Val Trp Ala Lys Gly Val Ser Ser Ser Glu Met Asn Val Thr 
            820                 825                 830         


Trp Glu Pro Val Gln Gln Asp Met Asn Gly Ile Leu Leu Gly Tyr Glu 
        835                 840                 845             


Ile Arg Tyr Trp Lys Ala Gly Asp Lys Glu Ala Ala Ala Asp Arg Val 
    850                 855                 860                 


Arg Thr Ala Gly Leu Asp Thr Ser Ala Arg Val Ser Gly Leu His Pro 
865                 870                 875                 880 


Asn Thr Lys Tyr His Val Thr Val Arg Ala Tyr Asn Arg Ala Gly Thr 
                885                 890                 895     


Gly Pro Ala Ser Pro Ser Ala Asn Ala Thr Thr Met Lys Pro Pro Pro 
            900                 905                 910         


Arg Arg Pro Pro Gly Asn Ile Ser Trp Thr Phe Ser Ser Ser Ser Leu 
        915                 920                 925             


Ser Ile Lys Trp Asp Pro Val Val Pro Phe Arg Asn Glu Ser Ala Val 
    930                 935                 940                 


Thr Gly Tyr Lys Met Leu Tyr Gln Asn Asp Leu His Leu Thr Pro Thr 
945                 950                 955                 960 


Leu His Leu Thr Gly Lys Asn Trp Ile Glu Ile Pro Val Pro Glu Asp 
                965                 970                 975     


Ile Gly His Ala Leu Val Gln Ile Arg Thr Thr Gly Pro Gly Gly Asp 
            980                 985                 990         


Gly Ile Pro Ala Glu Val His Ile  Val Arg Asn Gly Glu  Met Ala Leu 
        995                 1000                 1005             


Trp Asp  Pro Ile Arg Thr Pro  Pro Leu Glu Ser Ser  Pro Arg Pro 
    1010                 1015                 1020             


Gly Arg  Asn Thr Arg His Glu  Gln Val Glu Glu Leu  Glu Arg Ser 
    1025                 1030                 1035             


Ala His  Leu Thr Ile Leu Gln  Ser Lys Glu Glu Gly  Gln Ala Leu 
    1040                 1045                 1050             


Gly Pro  Arg Ala Leu Pro Pro  Ser Pro Ser Ser Ser  Ser Lys Asp 
    1055                 1060                 1065             


Pro Asp  Ala Val Pro Asp Asn  Ser Leu Gly Ala Pro  Ala Cys Pro 
    1070                 1075                 1080             


Ser Gly  
    1085 


<210>  3134
<211>  1040
<212>  PRT
<213>  Homo Sapiens

<400>  3134

Met Gly Thr Ala Thr Arg Arg Lys Pro His Leu Leu Leu Val Ala Ala 
1               5                   10                  15      


Val Ala Leu Val Ser Ser Ser Ala Trp Ser Ser Ala Leu Gly Ser Gln 
            20                  25                  30          


Thr Thr Phe Gly Pro Val Phe Glu Asp Gln Pro Leu Ser Val Leu Phe 
        35                  40                  45              


Pro Glu Glu Ser Thr Glu Glu Gln Val Leu Leu Ala Cys Arg Ala Arg 
    50                  55                  60                  


Ala Ser Pro Pro Ala Thr Tyr Arg Trp Lys Met Asn Gly Thr Glu Met 
65                  70                  75                  80  


Lys Leu Glu Pro Gly Ser Arg His Gln Leu Val Gly Gly Asn Leu Val 
                85                  90                  95      


Ile Met Asn Pro Thr Lys Ala Gln Asp Ala Gly Val Tyr Gln Cys Leu 
            100                 105                 110         


Ala Ser Asn Pro Val Gly Thr Val Val Ser Arg Glu Ala Ile Leu Arg 
        115                 120                 125             


Phe Gly Phe Leu Gln Glu Phe Ser Lys Glu Glu Arg Asp Pro Val Lys 
    130                 135                 140                 


Ala His Glu Gly Trp Gly Val Met Leu Pro Cys Asn Pro Pro Ala His 
145                 150                 155                 160 


Tyr Pro Gly Leu Ser Tyr Arg Trp Leu Leu Asn Glu Phe Pro Asn Phe 
                165                 170                 175     


Ile Pro Thr Asp Gly Arg His Phe Val Ser Gln Thr Thr Gly Asn Leu 
            180                 185                 190         


Tyr Ile Ala Arg Thr Asn Ala Ser Asp Leu Gly Asn Tyr Ser Cys Leu 
        195                 200                 205             


Ala Thr Ser His Met Asp Phe Ser Thr Lys Ser Val Phe Ser Lys Phe 
    210                 215                 220                 


Ala Gln Leu Asn Leu Ala Ala Glu Asp Thr Arg Leu Phe Ala Pro Ser 
225                 230                 235                 240 


Ile Lys Ala Arg Phe Pro Ala Glu Thr Tyr Ala Leu Val Gly Gln Gln 
                245                 250                 255     


Val Thr Leu Glu Cys Phe Ala Phe Gly Asn Pro Val Pro Arg Ile Lys 
            260                 265                 270         


Trp Arg Lys Val Asp Gly Ser Leu Ser Pro Gln Trp Thr Thr Ala Glu 
        275                 280                 285             


Pro Thr Leu Gln Ile Pro Ser Val Ser Phe Glu Asp Glu Gly Thr Tyr 
    290                 295                 300                 


Glu Cys Glu Ala Glu Asn Ser Lys Gly Arg Asp Thr Val Gln Gly Arg 
305                 310                 315                 320 


Ile Ile Val Gln Ala Gln Pro Glu Trp Leu Lys Val Ile Ser Asp Thr 
                325                 330                 335     


Glu Ala Asp Ile Gly Ser Asn Leu Arg Trp Gly Cys Ala Ala Ala Gly 
            340                 345                 350         


Lys Pro Arg Pro Thr Val Arg Trp Leu Arg Asn Gly Glu Pro Leu Ala 
        355                 360                 365             


Ser Gln Asn Arg Val Glu Val Leu Ala Gly Asp Leu Arg Phe Ser Lys 
    370                 375                 380                 


Leu Ser Leu Glu Asp Ser Gly Met Tyr Gln Cys Val Ala Glu Asn Lys 
385                 390                 395                 400 


His Gly Thr Ile Tyr Ala Ser Ala Glu Leu Ala Val Gln Ala Leu Ala 
                405                 410                 415     


Pro Asp Phe Arg Leu Asn Pro Val Arg Arg Leu Ile Pro Ala Ala Arg 
            420                 425                 430         


Gly Gly Glu Ile Leu Ile Pro Cys Gln Pro Arg Ala Ala Pro Lys Ala 
        435                 440                 445             


Val Val Leu Trp Ser Lys Gly Thr Glu Ile Leu Val Asn Ser Ser Arg 
    450                 455                 460                 


Val Thr Val Thr Pro Asp Gly Thr Leu Ile Ile Arg Asn Ile Ser Arg 
465                 470                 475                 480 


Ser Asp Glu Gly Lys Tyr Thr Cys Phe Ala Glu Asn Phe Met Gly Lys 
                485                 490                 495     


Ala Asn Ser Thr Gly Ile Leu Ser Val Arg Asp Ala Thr Lys Ile Thr 
            500                 505                 510         


Leu Ala Pro Ser Ser Ala Asp Ile Asn Leu Gly Asp Asn Leu Thr Leu 
        515                 520                 525             


Gln Cys His Ala Ser His Asp Pro Thr Met Asp Leu Thr Phe Thr Trp 
    530                 535                 540                 


Thr Leu Asp Asp Phe Pro Ile Asp Phe Asp Lys Pro Gly Gly His Tyr 
545                 550                 555                 560 


Arg Arg Thr Asn Val Lys Glu Thr Ile Gly Asp Leu Thr Ile Leu Asn 
                565                 570                 575     


Ala Gln Leu Arg His Gly Gly Lys Tyr Thr Cys Met Ala Gln Thr Val 
            580                 585                 590         


Val Asp Ser Ala Ser Lys Glu Ala Thr Val Leu Val Arg Gly Pro Pro 
        595                 600                 605             


Gly Pro Pro Gly Gly Val Val Val Arg Asp Ile Gly Asp Thr Thr Ile 
    610                 615                 620                 


Gln Leu Ser Trp Ser Arg Gly Phe Asp Asn His Ser Pro Ile Ala Lys 
625                 630                 635                 640 


Tyr Thr Leu Gln Ala Arg Thr Pro Pro Ala Gly Lys Trp Lys Gln Val 
                645                 650                 655     


Arg Thr Asn Pro Ala Asn Ile Glu Gly Asn Ala Glu Thr Ala Gln Val 
            660                 665                 670         


Leu Gly Leu Thr Pro Trp Met Asp Tyr Glu Phe Arg Val Ile Ala Ser 
        675                 680                 685             


Asn Ile Leu Gly Thr Gly Glu Pro Ser Gly Pro Ser Ser Lys Ile Arg 
    690                 695                 700                 


Thr Arg Glu Ala Ala Pro Ser Val Ala Pro Ser Gly Leu Ser Gly Gly 
705                 710                 715                 720 


Gly Gly Ala Pro Gly Glu Leu Ile Val Asn Trp Thr Pro Met Ser Arg 
                725                 730                 735     


Glu Tyr Gln Asn Gly Asp Gly Phe Gly Tyr Leu Leu Ser Phe Arg Arg 
            740                 745                 750         


Gln Gly Ser Thr His Trp Gln Thr Ala Arg Val Pro Gly Ala Asp Ala 
        755                 760                 765             


Gln Tyr Phe Val Tyr Ser Asn Glu Ser Val Arg Pro Tyr Thr Pro Phe 
    770                 775                 780                 


Glu Val Lys Ile Arg Ser Tyr Asn Arg Arg Gly Asp Gly Pro Glu Ser 
785                 790                 795                 800 


Leu Thr Ala Leu Val Tyr Ser Ala Glu Glu Glu Pro Arg Val Ala Pro 
                805                 810                 815     


Thr Lys Val Trp Ala Lys Gly Val Ser Ser Ser Glu Met Asn Val Thr 
            820                 825                 830         


Trp Glu Pro Val Gln Gln Asp Met Asn Gly Ile Leu Leu Gly Tyr Glu 
        835                 840                 845             


Ile Arg Tyr Trp Lys Ala Gly Asp Lys Glu Ala Ala Ala Asp Arg Val 
    850                 855                 860                 


Arg Thr Ala Gly Leu Asp Thr Ser Ala Arg Val Ser Gly Leu His Pro 
865                 870                 875                 880 


Asn Thr Lys Tyr His Val Thr Val Arg Ala Tyr Asn Arg Ala Gly Thr 
                885                 890                 895     


Gly Pro Ala Ser Pro Ser Ala Asn Ala Thr Thr Met Lys Pro Pro Pro 
            900                 905                 910         


Arg Arg Pro Pro Gly Asn Ile Ser Trp Thr Phe Ser Ser Ser Ser Leu 
        915                 920                 925             


Ser Ile Lys Trp Asp Pro Val Val Pro Phe Arg Asn Glu Ser Ala Val 
    930                 935                 940                 


Thr Gly Tyr Lys Met Leu Tyr Gln Asn Asp Leu His Leu Thr Pro Thr 
945                 950                 955                 960 


Leu His Leu Thr Gly Lys Asn Trp Ile Glu Ile Pro Val Pro Glu Asp 
                965                 970                 975     


Ile Gly His Ala Leu Val Gln Ile Arg Thr Thr Gly Pro Gly Gly Asp 
            980                 985                 990         


Gly Ile Pro Ala Glu Val His Ile  Val Arg Asn Gly Gly  Thr Ser Met 
        995                 1000                 1005             


Met Val  Glu Asn Met Ala Val  Arg Pro Ala Pro His  Pro Gly Thr 
    1010                 1015                 1020             


Val Ile  Ser His Ser Val Ala  Met Leu Ile Leu Ile  Gly Ser Leu 
    1025                 1030                 1035             


Glu Leu  
    1040 


<210>  3135
<211>  1040
<212>  PRT
<213>  Homo Sapiens

<400>  3135

Met Gly Thr Ala Thr Arg Arg Lys Pro His Leu Leu Leu Val Ala Ala 
1               5                   10                  15      


Val Ala Leu Val Ser Ser Ser Ala Trp Ser Ser Ala Leu Gly Ser Gln 
            20                  25                  30          


Thr Thr Phe Gly Pro Val Phe Glu Asp Gln Pro Leu Ser Val Leu Phe 
        35                  40                  45              


Pro Glu Glu Ser Thr Glu Glu Gln Val Leu Leu Ala Cys Arg Ala Arg 
    50                  55                  60                  


Ala Ser Pro Pro Ala Thr Tyr Arg Trp Lys Met Asn Gly Thr Glu Met 
65                  70                  75                  80  


Lys Leu Glu Pro Gly Ser Arg His Gln Leu Val Gly Gly Asn Leu Val 
                85                  90                  95      


Ile Met Asn Pro Thr Lys Ala Gln Asp Ala Gly Val Tyr Gln Cys Leu 
            100                 105                 110         


Ala Ser Asn Pro Val Gly Thr Val Val Ser Arg Glu Ala Ile Leu Arg 
        115                 120                 125             


Phe Gly Phe Leu Gln Glu Phe Ser Lys Glu Glu Arg Asp Pro Val Lys 
    130                 135                 140                 


Ala His Glu Gly Trp Gly Val Met Leu Pro Cys Asn Pro Pro Ala His 
145                 150                 155                 160 


Tyr Pro Gly Leu Ser Tyr Arg Trp Leu Leu Asn Glu Phe Pro Asn Phe 
                165                 170                 175     


Ile Pro Thr Asp Gly Arg His Phe Val Ser Gln Thr Thr Gly Asn Leu 
            180                 185                 190         


Tyr Ile Ala Arg Thr Asn Ala Ser Asp Leu Gly Asn Tyr Ser Cys Leu 
        195                 200                 205             


Ala Thr Ser His Met Asp Phe Ser Thr Lys Ser Val Phe Ser Lys Phe 
    210                 215                 220                 


Ala Gln Leu Asn Leu Ala Ala Glu Asp Thr Arg Leu Phe Ala Pro Ser 
225                 230                 235                 240 


Ile Lys Ala Arg Phe Pro Ala Glu Thr Tyr Ala Leu Val Gly Gln Gln 
                245                 250                 255     


Val Thr Leu Glu Cys Phe Ala Phe Gly Asn Pro Val Pro Arg Ile Lys 
            260                 265                 270         


Trp Arg Lys Val Asp Gly Ser Leu Ser Pro Gln Trp Thr Thr Ala Glu 
        275                 280                 285             


Pro Thr Leu Gln Ile Pro Ser Val Ser Phe Glu Asp Glu Gly Thr Tyr 
    290                 295                 300                 


Glu Cys Glu Ala Glu Asn Ser Lys Gly Arg Asp Thr Val Gln Gly Arg 
305                 310                 315                 320 


Ile Ile Val Gln Ala Gln Pro Glu Trp Leu Lys Val Ile Ser Asp Thr 
                325                 330                 335     


Glu Ala Asp Ile Gly Ser Asn Leu Arg Trp Gly Cys Ala Ala Ala Gly 
            340                 345                 350         


Lys Pro Arg Pro Thr Val Arg Trp Leu Arg Asn Gly Glu Pro Leu Ala 
        355                 360                 365             


Ser Gln Asn Arg Val Glu Val Leu Ala Gly Asp Leu Arg Phe Ser Lys 
    370                 375                 380                 


Leu Ser Leu Glu Asp Ser Gly Met Tyr Gln Cys Val Ala Glu Asn Lys 
385                 390                 395                 400 


His Gly Thr Ile Tyr Ala Ser Ala Glu Leu Ala Val Gln Ala Leu Ala 
                405                 410                 415     


Pro Asp Phe Arg Leu Asn Pro Val Arg Arg Leu Ile Pro Ala Ala Arg 
            420                 425                 430         


Gly Gly Glu Ile Leu Ile Pro Cys Gln Pro Arg Ala Ala Pro Lys Ala 
        435                 440                 445             


Val Val Leu Trp Ser Lys Gly Thr Glu Ile Leu Val Asn Ser Ser Arg 
    450                 455                 460                 


Val Thr Val Thr Pro Asp Gly Thr Leu Ile Ile Arg Asn Ile Ser Arg 
465                 470                 475                 480 


Ser Asp Glu Gly Lys Tyr Thr Cys Phe Ala Glu Asn Phe Met Gly Lys 
                485                 490                 495     


Ala Asn Ser Thr Gly Ile Leu Ser Val Arg Asp Ala Thr Lys Ile Thr 
            500                 505                 510         


Leu Ala Pro Ser Ser Ala Asp Ile Asn Leu Gly Asp Asn Leu Thr Leu 
        515                 520                 525             


Gln Cys His Ala Ser His Asp Pro Thr Met Asp Leu Thr Phe Thr Trp 
    530                 535                 540                 


Thr Leu Asp Asp Phe Pro Ile Asp Phe Asp Lys Pro Gly Gly His Tyr 
545                 550                 555                 560 


Arg Arg Thr Asn Val Lys Glu Thr Ile Gly Asp Leu Thr Ile Leu Asn 
                565                 570                 575     


Ala Gln Leu Arg His Gly Gly Lys Tyr Thr Cys Met Ala Gln Thr Val 
            580                 585                 590         


Val Asp Ser Ala Ser Lys Glu Ala Thr Val Leu Val Arg Gly Pro Pro 
        595                 600                 605             


Gly Pro Pro Gly Gly Val Val Val Arg Asp Ile Gly Asp Thr Thr Ile 
    610                 615                 620                 


Gln Leu Ser Trp Ser Arg Gly Phe Asp Asn His Ser Pro Ile Ala Lys 
625                 630                 635                 640 


Tyr Thr Leu Gln Ala Arg Thr Pro Pro Ala Gly Lys Trp Lys Gln Val 
                645                 650                 655     


Arg Thr Asn Pro Ala Asn Ile Glu Gly Asn Ala Glu Thr Ala Gln Val 
            660                 665                 670         


Leu Gly Leu Thr Pro Trp Met Asp Tyr Glu Phe Arg Val Ile Ala Ser 
        675                 680                 685             


Asn Ile Leu Gly Thr Gly Glu Pro Ser Gly Pro Ser Ser Lys Ile Arg 
    690                 695                 700                 


Thr Arg Glu Ala Ala Pro Ser Val Ala Pro Ser Gly Leu Ser Gly Gly 
705                 710                 715                 720 


Gly Gly Ala Pro Gly Glu Leu Ile Val Asn Trp Thr Pro Met Ser Arg 
                725                 730                 735     


Glu Tyr Gln Asn Gly Asp Gly Phe Gly Tyr Leu Leu Ser Phe Arg Arg 
            740                 745                 750         


Gln Gly Ser Thr His Trp Gln Thr Ala Arg Val Pro Gly Ala Asp Ala 
        755                 760                 765             


Gln Tyr Phe Val Tyr Ser Asn Glu Ser Val Arg Pro Tyr Thr Pro Phe 
    770                 775                 780                 


Glu Val Lys Ile Arg Ser Tyr Asn Arg Arg Gly Asp Gly Pro Glu Ser 
785                 790                 795                 800 


Leu Thr Ala Leu Val Tyr Ser Ala Glu Glu Glu Pro Arg Val Ala Pro 
                805                 810                 815     


Thr Lys Val Trp Ala Lys Gly Val Ser Ser Ser Glu Met Asn Val Thr 
            820                 825                 830         


Trp Glu Pro Val Gln Gln Asp Met Asn Gly Ile Leu Leu Gly Tyr Glu 
        835                 840                 845             


Ile Arg Tyr Trp Lys Ala Gly Asp Lys Glu Ala Ala Ala Asp Arg Val 
    850                 855                 860                 


Arg Thr Ala Gly Leu Asp Thr Ser Ala Arg Val Ser Gly Leu His Pro 
865                 870                 875                 880 


Asn Thr Lys Tyr His Val Thr Val Arg Ala Tyr Asn Arg Ala Gly Thr 
                885                 890                 895     


Gly Pro Ala Ser Pro Ser Ala Asn Ala Thr Thr Met Lys Pro Pro Pro 
            900                 905                 910         


Arg Arg Pro Pro Gly Asn Ile Ser Trp Thr Phe Ser Ser Ser Ser Leu 
        915                 920                 925             


Ser Ile Lys Trp Asp Pro Val Val Pro Phe Arg Asn Glu Ser Ala Val 
    930                 935                 940                 


Thr Gly Tyr Lys Met Leu Tyr Gln Asn Asp Leu His Leu Thr Pro Thr 
945                 950                 955                 960 


Leu His Leu Thr Gly Lys Asn Trp Ile Glu Ile Pro Val Pro Glu Asp 
                965                 970                 975     


Ile Gly His Ala Leu Val Gln Ile Arg Thr Thr Gly Pro Gly Gly Asp 
            980                 985                 990         


Gly Ile Pro Ala Glu Val His Ile  Val Arg Asn Gly Gly  Thr Ser Met 
        995                 1000                 1005             


Met Val  Glu Asn Met Ala Val  Arg Pro Ala Pro His  Pro Gly Thr 
    1010                 1015                 1020             


Val Ile  Ser His Ser Val Ala  Met Leu Ile Leu Ile  Gly Ser Leu 
    1025                 1030                 1035             


Glu Leu  
    1040 


<210>  3136
<211>  764
<212>  PRT
<213>  Homo Sapiens

<400>  3136

Met Gly Thr Ala Thr Arg Arg Lys Pro His Leu Leu Leu Val Ala Ala 
1               5                   10                  15      


Val Ala Leu Val Ser Ser Ser Ala Trp Ser Ser Ala Leu Gly Ser Gln 
            20                  25                  30          


Thr Thr Phe Gly Pro Val Phe Glu Asp Gln Pro Leu Ser Val Leu Phe 
        35                  40                  45              


Pro Glu Glu Ser Thr Glu Glu Gln Val Leu Leu Ala Cys Arg Ala Arg 
    50                  55                  60                  


Ala Ser Pro Pro Ala Thr Tyr Arg Trp Lys Met Asn Gly Thr Glu Met 
65                  70                  75                  80  


Lys Leu Glu Pro Gly Ser Arg His Gln Leu Val Gly Gly Asn Leu Val 
                85                  90                  95      


Ile Met Asn Pro Thr Lys Ala Gln Asp Ala Gly Val Tyr Gln Cys Leu 
            100                 105                 110         


Ala Ser Asn Pro Val Gly Thr Val Val Ser Arg Glu Ala Ile Leu Arg 
        115                 120                 125             


Phe Gly Phe Leu Gln Glu Phe Ser Lys Glu Glu Arg Asp Pro Val Lys 
    130                 135                 140                 


Ala His Glu Gly Trp Gly Val Met Leu Pro Cys Asn Pro Pro Ala His 
145                 150                 155                 160 


Tyr Pro Gly Leu Ser Tyr Arg Trp Leu Leu Asn Glu Phe Pro Asn Phe 
                165                 170                 175     


Ile Pro Thr Asp Gly Arg His Phe Val Ser Gln Thr Thr Gly Asn Leu 
            180                 185                 190         


Tyr Ile Ala Arg Thr Asn Ala Ser Asp Leu Gly Asn Tyr Ser Cys Leu 
        195                 200                 205             


Ala Thr Ser His Met Asp Phe Ser Thr Lys Ser Val Phe Ser Lys Phe 
    210                 215                 220                 


Ala Gln Leu Asn Leu Ala Ala Glu Asp Thr Arg Leu Phe Ala Pro Ser 
225                 230                 235                 240 


Ile Lys Ala Arg Phe Pro Ala Glu Thr Tyr Ala Leu Val Gly Gln Gln 
                245                 250                 255     


Val Thr Leu Glu Cys Phe Ala Phe Gly Asn Pro Val Pro Arg Ile Lys 
            260                 265                 270         


Trp Arg Lys Val Asp Gly Ser Leu Ser Pro Gln Trp Thr Thr Ala Glu 
        275                 280                 285             


Pro Thr Leu Gln Ile Pro Ser Val Ser Phe Glu Asp Glu Gly Thr Tyr 
    290                 295                 300                 


Glu Cys Glu Ala Glu Asn Ser Lys Gly Arg Asp Thr Val Gln Gly Arg 
305                 310                 315                 320 


Ile Ile Val Gln Ala Gln Pro Glu Trp Leu Lys Val Ile Ser Asp Thr 
                325                 330                 335     


Glu Ala Asp Ile Gly Ser Asn Leu Arg Trp Gly Cys Ala Ala Ala Gly 
            340                 345                 350         


Lys Pro Arg Pro Thr Val Arg Trp Leu Arg Asn Gly Glu Pro Leu Ala 
        355                 360                 365             


Ser Gln Asn Arg Val Glu Val Leu Ala Gly Asp Leu Arg Phe Ser Lys 
    370                 375                 380                 


Leu Ser Leu Glu Asp Ser Gly Met Tyr Gln Cys Val Ala Glu Asn Lys 
385                 390                 395                 400 


His Gly Thr Ile Tyr Ala Ser Ala Glu Leu Ala Val Gln Ala Leu Ala 
                405                 410                 415     


Pro Asp Phe Arg Leu Asn Pro Val Arg Arg Leu Ile Pro Ala Ala Arg 
            420                 425                 430         


Gly Gly Glu Ile Leu Ile Pro Cys Gln Pro Arg Ala Ala Pro Lys Ala 
        435                 440                 445             


Val Val Leu Trp Ser Lys Gly Thr Glu Ile Leu Val Asn Ser Ser Arg 
    450                 455                 460                 


Val Thr Val Thr Pro Asp Gly Thr Leu Ile Ile Arg Asn Ile Ser Arg 
465                 470                 475                 480 


Ser Asp Glu Gly Lys Tyr Thr Cys Phe Ala Glu Asn Phe Met Gly Lys 
                485                 490                 495     


Ala Asn Ser Thr Gly Ile Leu Ser Val Arg Asp Ala Thr Lys Ile Thr 
            500                 505                 510         


Leu Ala Pro Ser Ser Ala Asp Ile Asn Leu Gly Asp Asn Leu Thr Leu 
        515                 520                 525             


Gln Cys His Ala Ser His Asp Pro Thr Met Asp Leu Thr Phe Thr Trp 
    530                 535                 540                 


Thr Leu Asp Asp Phe Pro Ile Asp Phe Asp Lys Pro Gly Gly His Tyr 
545                 550                 555                 560 


Arg Arg Thr Asn Val Lys Glu Thr Ile Gly Asp Leu Thr Ile Leu Asn 
                565                 570                 575     


Ala Gln Leu Arg His Gly Gly Lys Tyr Thr Cys Met Ala Gln Thr Val 
            580                 585                 590         


Val Asp Ser Ala Ser Lys Glu Ala Thr Val Leu Val Arg Gly Pro Pro 
        595                 600                 605             


Gly Pro Pro Gly Gly Val Val Val Arg Asp Ile Gly Asp Thr Thr Ile 
    610                 615                 620                 


Gln Leu Ser Trp Ser Arg Gly Phe Asp Asn His Ser Pro Ile Ala Lys 
625                 630                 635                 640 


Tyr Thr Leu Gln Ala Arg Thr Pro Pro Ala Gly Lys Trp Lys Gln Val 
                645                 650                 655     


Arg Thr Asn Pro Ala Asn Ile Glu Gly Asn Ala Glu Thr Ala Gln Val 
            660                 665                 670         


Leu Gly Leu Thr Pro Trp Met Asp Tyr Glu Phe Arg Val Ile Ala Ser 
        675                 680                 685             


Asn Ile Leu Gly Thr Gly Glu Pro Ser Gly Pro Ser Ser Lys Ile Arg 
    690                 695                 700                 


Thr Arg Glu Ala Ala Pro Ser Val Ala Pro Ser Gly Leu Ser Gly Gly 
705                 710                 715                 720 


Gly Gly Ala Pro Gly Glu Leu Ile Val Asn Trp Thr Ala Gly Gln His 
                725                 730                 735     


Ser Leu Ala Asp Arg Pro Gly Ala Trp Arg Arg Cys Pro Val Leu Cys 
            740                 745                 750         


Leu Gln Gln Arg Glu Arg Pro Ala Leu His Ala Leu 
        755                 760                 


<210>  3137
<211>  41
<212>  PRT
<213>  Homo Sapiens

<400>  3137

Met Gly Thr Ala Thr Arg Arg Lys Pro His Leu Leu Leu Val Ala Ala 
1               5                   10                  15      


Val Ala Leu Val Ser Ser Ser Gly Glu Asp Thr Glu Ala Gln Lys Ser 
            20                  25                  30          


Ser Ile Thr Phe Pro Arg Ser His Ser 
        35                  40      


<210>  3138
<211>  41
<212>  PRT
<213>  Homo Sapiens

<400>  3138

Met Gly Thr Ala Thr Arg Arg Lys Pro His Leu Leu Leu Val Ala Ala 
1               5                   10                  15      


Val Ala Leu Val Ser Ser Ser Gly Glu Asp Thr Glu Ala Gln Lys Ser 
            20                  25                  30          


Ser Ile Thr Phe Pro Arg Ser His Ser 
        35                  40      


<210>  3139
<211>  527
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3139

Xaa Ala Gln Thr Val Val Asp Ser Ala Ser Lys Glu Ala Thr Val Leu 
1               5                   10                  15      


Val Arg Gly Pro Pro Gly Pro Pro Gly Gly Val Val Val Arg Asp Ile 
            20                  25                  30          


Gly Asp Thr Thr Ile Gln Leu Ser Trp Ser Arg Gly Phe Asp Asn His 
        35                  40                  45              


Ser Pro Ile Ala Lys Tyr Thr Leu Gln Ala Arg Thr Pro Pro Ala Gly 
    50                  55                  60                  


Lys Trp Lys Gln Val Arg Thr Asn Pro Ala Asn Ile Glu Gly Asn Ala 
65                  70                  75                  80  


Glu Thr Ala Gln Val Leu Gly Leu Thr Pro Trp Met Asp Tyr Glu Phe 
                85                  90                  95      


Arg Val Ile Ala Ser Asn Ile Leu Gly Thr Gly Glu Pro Ser Gly Pro 
            100                 105                 110         


Ser Ser Lys Ile Arg Thr Arg Glu Ala Ala Pro Ser Val Ala Pro Ser 
        115                 120                 125             


Gly Leu Ser Gly Gly Gly Gly Ala Pro Gly Glu Leu Ile Val Asn Trp 
    130                 135                 140                 


Thr Pro Met Ser Arg Glu Tyr Gln Asn Gly Asp Gly Phe Gly Tyr Leu 
145                 150                 155                 160 


Leu Ser Phe Arg Arg Gln Gly Ser Thr His Trp Gln Thr Ala Arg Val 
                165                 170                 175     


Pro Gly Ala Asp Ala Gln Tyr Phe Val Tyr Ser Asn Glu Ser Val Arg 
            180                 185                 190         


Pro Tyr Thr Pro Phe Glu Val Lys Ile Arg Ser Tyr Asn Arg Arg Gly 
        195                 200                 205             


Asp Gly Pro Glu Ser Leu Thr Ala Leu Val Tyr Ser Ala Glu Glu Glu 
    210                 215                 220                 


Pro Arg Val Ala Pro Thr Lys Val Trp Ala Lys Gly Val Ser Ser Ser 
225                 230                 235                 240 


Glu Met Asn Val Thr Trp Glu Pro Val Gln Gln Asp Met Asn Gly Ile 
                245                 250                 255     


Leu Leu Gly Tyr Glu Ile Arg Tyr Trp Lys Ala Gly Asp Lys Glu Ala 
            260                 265                 270         


Ala Ala Asp Arg Val Arg Thr Ala Gly Leu Asp Thr Ser Ala Arg Val 
        275                 280                 285             


Ser Gly Leu His Pro Asn Thr Lys Tyr His Val Thr Val Arg Ala Tyr 
    290                 295                 300                 


Asn Arg Ala Gly Thr Gly Pro Ala Ser Pro Ser Ala Asn Ala Thr Thr 
305                 310                 315                 320 


Met Lys Pro Pro Pro Arg Arg Pro Pro Gly Asn Ile Ser Trp Thr Phe 
                325                 330                 335     


Ser Ser Ser Ser Leu Ser Ile Lys Trp Asp Pro Val Val Pro Phe Arg 
            340                 345                 350         


Asn Glu Ser Ala Val Thr Gly Tyr Lys Met Leu Tyr Gln Asn Asp Leu 
        355                 360                 365             


His Leu Thr Pro Thr Leu His Leu Thr Gly Lys Asn Trp Ile Glu Ile 
    370                 375                 380                 


Pro Val Pro Glu Asp Ile Gly His Ala Leu Val Gln Ile Arg Thr Thr 
385                 390                 395                 400 


Gly Pro Gly Gly Asp Gly Ile Pro Ala Glu Val His Ile Val Arg Asn 
                405                 410                 415     


Gly Gly Ala Ala Pro Pro Leu Pro Leu Ser Pro Arg Glu Ile Gln Asp 
            420                 425                 430         


Pro Pro Arg Tyr Leu Arg Gly Ser Phe Pro Pro Arg Pro Thr Pro Ile 
        435                 440                 445             


Ser Thr Arg Lys Gly Lys Trp Lys Ala Gly Arg Asn Gln Val Gln Ser 
    450                 455                 460                 


Ser Leu Arg Thr Ala Ser Pro Pro Pro Phe Tyr Pro Ala Pro Arg Thr 
465                 470                 475                 480 


Ser Pro Arg Ala Arg Glu Gly Arg Arg Val Gln Gly Glu Ala Glu Asp 
                485                 490                 495     


Gln Pro Ala Ile Ala Asn Gly Leu Gln Ser Thr Val Gly Val Gly Leu 
            500                 505                 510         


Arg Arg Pro Pro Ser Arg Pro Leu Pro Gly Leu Gln Leu Ala Leu 
        515                 520                 525         


<210>  3140
<211>  115
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3140

Xaa Gly Lys Ala Asn Ser Thr Gly Ile Leu Ser Val Arg Asp Ala Thr 
1               5                   10                  15      


Lys Ile Thr Leu Ala Pro Ser Ser Ala Asp Ile Asn Leu Gly Asp Asn 
            20                  25                  30          


Leu Thr Leu Gln Cys His Ala Ser His Asp Pro Thr Met Asp Leu Thr 
        35                  40                  45              


Phe Thr Trp Thr Leu Asp Asp Phe Pro Ile Asp Phe Asp Lys Pro Gly 
    50                  55                  60                  


Gly His Tyr Arg Arg Thr Asn Val Lys Glu Thr Ile Gly Asp Leu Thr 
65                  70                  75                  80  


Ile Leu Asn Ala Gln Leu Arg His Gly Gly Lys Tyr Thr Cys Met Ala 
                85                  90                  95      


Gln Thr Val Val Asp Ser Ala Ser Lys Glu Ala Thr Val Leu Val Arg 
            100                 105                 110         


Gly Pro Lys 
        115 


<210>  3141
<211>  473
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3141

Xaa Ile Lys Trp Arg Lys Val Asp Gly Ser Leu Ser Pro Gln Trp Thr 
1               5                   10                  15      


Thr Ala Glu Pro Thr Leu Gln Ile Pro Ser Val Ser Phe Glu Asp Glu 
            20                  25                  30          


Gly Thr Tyr Glu Cys Glu Ala Glu Asn Ser Lys Gly Arg Asp Thr Val 
        35                  40                  45              


Gln Gly Arg Ile Ile Val Gln Ala Gln Pro Glu Trp Leu Lys Val Ile 
    50                  55                  60                  


Ser Asp Thr Glu Ala Asp Ile Gly Ser Asn Leu Arg Trp Gly Cys Ala 
65                  70                  75                  80  


Ala Ala Gly Lys Pro Arg Pro Thr Val Arg Trp Leu Arg Asn Gly Glu 
                85                  90                  95      


Pro Leu Ala Ser Gln Asn Arg Val Glu Val Leu Ala Gly Asp Leu Arg 
            100                 105                 110         


Phe Ser Lys Leu Ser Leu Glu Asp Ser Gly Met Tyr Gln Cys Val Ala 
        115                 120                 125             


Glu Asn Lys His Gly Thr Ile Tyr Ala Ser Ala Glu Leu Ala Val Gln 
    130                 135                 140                 


Ala Leu Ala Pro Asp Phe Arg Leu Asn Pro Val Arg Arg Leu Ile Pro 
145                 150                 155                 160 


Ala Ala Arg Gly Gly Glu Ile Leu Ile Pro Cys Gln Pro Arg Ala Ala 
                165                 170                 175     


Pro Lys Ala Val Val Leu Trp Ser Lys Gly Thr Glu Ile Leu Val Asn 
            180                 185                 190         


Ser Ser Arg Val Thr Val Thr Pro Asp Gly Thr Leu Ile Ile Arg Asn 
        195                 200                 205             


Ile Ser Arg Ser Asp Glu Gly Lys Tyr Thr Cys Phe Ala Glu Asn Phe 
    210                 215                 220                 


Met Gly Lys Ala Asn Ser Thr Gly Ile Leu Ser Val Arg Asp Ala Thr 
225                 230                 235                 240 


Lys Ile Thr Leu Ala Pro Ser Ser Ala Asp Ile Asn Leu Gly Asp Asn 
                245                 250                 255     


Leu Thr Leu Gln Cys His Ala Ser His Asp Pro Thr Met Asp Leu Thr 
            260                 265                 270         


Phe Thr Trp Thr Leu Asp Asp Phe Pro Ile Asp Phe Asp Lys Pro Gly 
        275                 280                 285             


Gly His Tyr Arg Arg Thr Asn Val Lys Glu Thr Ile Gly Asp Leu Thr 
    290                 295                 300                 


Ile Leu Asn Ala Gln Leu Arg His Gly Gly Lys Tyr Thr Cys Met Ala 
305                 310                 315                 320 


Gln Thr Val Val Asp Ser Ala Ser Lys Glu Ala Thr Val Leu Val Arg 
                325                 330                 335     


Gly Pro Pro Gly Pro Pro Gly Gly Val Val Val Arg Asp Ile Gly Asp 
            340                 345                 350         


Thr Thr Ile Gln Leu Ser Trp Ser Arg Gly Phe Asp Asn His Ser Pro 
        355                 360                 365             


Ile Ala Lys Tyr Thr Leu Gln Ala Arg Thr Pro Pro Ala Gly Lys Trp 
    370                 375                 380                 


Lys Gln Val Arg Thr Asn Pro Ala Asn Ile Glu Gly Asn Ala Glu Thr 
385                 390                 395                 400 


Ala Gln Val Leu Gly Leu Thr Pro Trp Met Asp Tyr Glu Phe Arg Val 
                405                 410                 415     


Ile Ala Ser Asn Ile Leu Gly Thr Gly Glu Pro Ser Gly Pro Ser Ser 
            420                 425                 430         


Lys Ile Arg Thr Arg Glu Ala Ala Pro Ser Val Ala Pro Ser Gly Leu 
        435                 440                 445             


Ser Gly Gly Gly Gly Ala Pro Gly Glu Leu Ile Val Asn Trp Thr Gln 
    450                 455                 460                 


Arg Glu Arg Pro Ala Leu His Ala Leu 
465                 470             


<210>  3142
<211>  1011
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3142

Xaa Pro Thr Asp Gly Arg His Phe Val Ser Gln Thr Thr Gly Asn Leu 
1               5                   10                  15      


Tyr Ile Ala Arg Thr Asn Ala Ser Asp Leu Gly Asn Tyr Ser Cys Leu 
            20                  25                  30          


Ala Thr Ser His Met Asp Phe Ser Thr Lys Ser Val Phe Ser Lys Phe 
        35                  40                  45              


Ala Gln Leu Asn Leu Ala Ala Glu Asp Thr Arg Leu Phe Ala Pro Ser 
    50                  55                  60                  


Ile Lys Ala Arg Phe Pro Ala Glu Thr Tyr Ala Leu Val Gly Gln Gln 
65                  70                  75                  80  


Val Thr Leu Glu Cys Phe Ala Phe Gly Asn Pro Val Pro Arg Ile Lys 
                85                  90                  95      


Trp Arg Lys Val Asp Gly Ser Leu Ser Pro Gln Trp Thr Thr Ala Glu 
            100                 105                 110         


Pro Thr Leu Gln Ile Pro Ser Val Ser Phe Glu Asp Glu Gly Thr Tyr 
        115                 120                 125             


Glu Cys Glu Ala Glu Asn Ser Lys Gly Arg Asp Thr Val Gln Gly Arg 
    130                 135                 140                 


Ile Ile Val Gln Ala Gln Pro Glu Trp Leu Lys Val Ile Ser Asp Thr 
145                 150                 155                 160 


Glu Ala Asp Ile Gly Ser Asn Leu Arg Trp Gly Cys Ala Ala Ala Gly 
                165                 170                 175     


Lys Pro Arg Pro Thr Val Arg Trp Leu Arg Asn Gly Glu Pro Leu Ala 
            180                 185                 190         


Ser Gln Asn Arg Val Glu Val Leu Ala Gly Asp Leu Arg Phe Ser Lys 
        195                 200                 205             


Leu Ser Leu Glu Asp Ser Gly Met Tyr Gln Cys Val Ala Glu Asn Lys 
    210                 215                 220                 


His Gly Thr Ile Tyr Ala Ser Ala Glu Leu Ala Val Gln Ala Leu Ala 
225                 230                 235                 240 


Pro Asp Phe Arg Leu Asn Pro Val Arg Arg Leu Ile Pro Ala Ala Arg 
                245                 250                 255     


Gly Gly Glu Ile Leu Ile Pro Cys Gln Pro Arg Ala Ala Pro Lys Ala 
            260                 265                 270         


Val Val Leu Trp Ser Lys Gly Thr Glu Ile Leu Val Asn Ser Ser Arg 
        275                 280                 285             


Val Thr Val Thr Pro Asp Gly Thr Leu Ile Ile Arg Asn Ile Ser Arg 
    290                 295                 300                 


Ser Asp Glu Gly Lys Tyr Thr Cys Phe Ala Glu Asn Phe Met Gly Lys 
305                 310                 315                 320 


Ala Asn Ser Thr Gly Ile Leu Ser Val Arg Asp Ala Thr Lys Ile Thr 
                325                 330                 335     


Leu Ala Pro Ser Ser Ala Asp Ile Asn Leu Gly Asp Asn Leu Thr Leu 
            340                 345                 350         


Gln Cys His Ala Ser His Asp Pro Thr Met Asp Leu Thr Phe Thr Trp 
        355                 360                 365             


Thr Leu Asp Asp Phe Pro Ile Asp Phe Asp Lys Pro Gly Gly His Tyr 
    370                 375                 380                 


Arg Arg Thr Asn Val Lys Glu Thr Ile Gly Asp Leu Thr Ile Leu Asn 
385                 390                 395                 400 


Ala Gln Leu Arg His Gly Gly Lys Tyr Thr Cys Met Ala Gln Thr Val 
                405                 410                 415     


Val Asp Ser Ala Ser Lys Glu Ala Thr Val Leu Val Arg Gly Pro Pro 
            420                 425                 430         


Gly Pro Pro Gly Gly Val Val Val Arg Asp Ile Gly Asp Thr Thr Ile 
        435                 440                 445             


Gln Leu Ser Trp Ser Arg Gly Phe Asp Asn His Ser Pro Ile Ala Lys 
    450                 455                 460                 


Tyr Thr Leu Gln Ala Arg Thr Pro Pro Ala Gly Lys Trp Lys Gln Val 
465                 470                 475                 480 


Arg Thr Asn Pro Ala Asn Ile Glu Gly Asn Ala Glu Thr Ala Gln Val 
                485                 490                 495     


Leu Gly Leu Thr Pro Trp Met Asp Tyr Glu Phe Arg Val Ile Ala Ser 
            500                 505                 510         


Asn Ile Leu Gly Thr Gly Glu Pro Ser Gly Pro Ser Ser Lys Ile Arg 
        515                 520                 525             


Thr Arg Glu Ala Ala Pro Ser Val Ala Pro Ser Gly Leu Ser Gly Gly 
    530                 535                 540                 


Gly Gly Ala Pro Gly Glu Leu Ile Val Asn Trp Thr Pro Met Ser Arg 
545                 550                 555                 560 


Glu Tyr Gln Asn Gly Asp Gly Phe Gly Tyr Leu Leu Ser Phe Arg Arg 
                565                 570                 575     


Gln Gly Ser Thr His Trp Gln Thr Ala Arg Val Pro Gly Ala Asp Ala 
            580                 585                 590         


Gln Tyr Phe Val Tyr Ser Asn Glu Ser Val Arg Pro Tyr Thr Pro Phe 
        595                 600                 605             


Glu Val Lys Ile Arg Ser Tyr Asn Arg Arg Gly Asp Gly Pro Glu Ser 
    610                 615                 620                 


Leu Thr Ala Leu Val Tyr Ser Ala Glu Glu Glu Pro Arg Val Ala Pro 
625                 630                 635                 640 


Thr Lys Val Trp Ala Lys Gly Val Ser Ser Ser Glu Met Asn Val Thr 
                645                 650                 655     


Trp Glu Pro Val Gln Gln Asp Met Asn Gly Ile Leu Leu Gly Tyr Glu 
            660                 665                 670         


Ile Arg Tyr Trp Lys Ala Gly Asp Lys Glu Ala Ala Ala Asp Arg Val 
        675                 680                 685             


Arg Thr Ala Gly Leu Asp Thr Ser Ala Arg Val Ser Gly Leu His Pro 
    690                 695                 700                 


Asn Thr Lys Tyr His Val Thr Val Arg Ala Tyr Asn Arg Ala Gly Thr 
705                 710                 715                 720 


Gly Pro Ala Ser Pro Ser Ala Asn Ala Thr Thr Met Lys Pro Pro Pro 
                725                 730                 735     


Arg Arg Pro Pro Gly Asn Ile Ser Trp Thr Phe Ser Ser Ser Ser Leu 
            740                 745                 750         


Ser Ile Lys Trp Asp Pro Val Val Pro Phe Arg Asn Glu Ser Ala Val 
        755                 760                 765             


Thr Gly Tyr Lys Met Leu Tyr Gln Asn Asp Leu His Leu Thr Pro Thr 
    770                 775                 780                 


Leu His Leu Thr Gly Lys Asn Trp Ile Glu Ile Pro Val Pro Glu Asp 
785                 790                 795                 800 


Ile Gly His Ala Leu Val Gln Ile Arg Thr Thr Gly Pro Gly Gly Asp 
                805                 810                 815     


Gly Ile Pro Ala Glu Val His Ile Val Arg Asn Gly Gly Ala Ala Pro 
            820                 825                 830         


Pro Leu Pro Leu Ser Pro Arg Glu Ile Gln Asp Pro Pro Arg Tyr Leu 
        835                 840                 845             


Arg Gly Ser Phe Pro Pro Arg Pro Thr Pro Ile Ser Thr Arg Lys Gly 
    850                 855                 860                 


Lys Trp Lys Ala Gly Arg Asn Gln Val Gln Ser Ser Leu Arg Thr Ala 
865                 870                 875                 880 


Ser Pro Pro Pro Phe Tyr Pro Ala Pro Arg Thr Ser Pro Arg Ala Arg 
                885                 890                 895     


Glu Gly Arg Arg Val Gln Gly Glu Ala Glu Asp Gln Pro Ala Ile Ala 
            900                 905                 910         


Asn Gly Leu Gln Ser Thr Val Gly Val Gly Leu Arg Arg Pro Pro Ser 
        915                 920                 925             


Arg Pro Leu Pro Gly Leu Gln Leu Ala Leu His Lys His Asp Gly Gly 
    930                 935                 940                 


Glu His Gly Ser Pro Pro Ser Thr Thr Pro Trp His Arg His Phe Pro 
945                 950                 955                 960 


Leu Arg Gly Asp Ala Asp Pro His Arg Leu Pro Gly Ala Leu Ile Leu 
                965                 970                 975     


Glu Pro Leu Pro Leu Arg Arg Ser Trp Thr Pro Pro Pro Thr Asp Thr 
            980                 985                 990         


Ala Ser Pro Phe Leu Leu Pro Arg  Trp Pro Asp Thr Val  Pro Glu Ser 
        995                 1000                 1005             


Gly Trp  Phe 
    1010     


<210>  3143
<211>  1028
<212>  PRT
<213>  Homo Sapiens

<400>  3143

Met Met Phe Pro Trp Lys Gln Leu Ile Leu Leu Ser Phe Ile Gly Cys 
1               5                   10                  15      


Leu Gly Gly Glu Leu Leu Leu Gln Gly Pro Val Phe Ile Lys Glu Pro 
            20                  25                  30          


Ser Asn Ser Ile Phe Pro Val Gly Ser Glu Asp Lys Lys Ile Thr Leu 
        35                  40                  45              


His Cys Glu Ala Arg Gly Asn Pro Ser Pro His Tyr Arg Trp Gln Leu 
    50                  55                  60                  


Asn Gly Ser Asp Ile Asp Met Ser Met Glu His Arg Tyr Lys Leu Asn 
65                  70                  75                  80  


Gly Gly Asn Leu Val Val Ile Asn Pro Asn Arg Asn Trp Asp Thr Gly 
                85                  90                  95      


Thr Tyr Gln Cys Phe Ala Thr Asn Ser Leu Gly Thr Ile Val Ser Arg 
            100                 105                 110         


Glu Ala Lys Leu Gln Phe Ala Tyr Leu Glu Asn Phe Lys Thr Lys Met 
        115                 120                 125             


Arg Ser Thr Val Ser Val Arg Glu Gly Gln Gly Val Val Leu Leu Cys 
    130                 135                 140                 


Gly Pro Pro Pro His Ser Gly Glu Leu Ser Tyr Ala Trp Ile Phe Asn 
145                 150                 155                 160 


Glu Tyr Pro Ser Phe Val Glu Glu Asp Ser Arg Arg Phe Val Ser Gln 
                165                 170                 175     


Glu Thr Gly His Leu Tyr Ile Ser Lys Val Glu Pro Ser Asp Val Gly 
            180                 185                 190         


Asn Tyr Thr Cys Val Val Thr Ser Met Val Thr Asn Ala Arg Val Leu 
        195                 200                 205             


Gly Ser Pro Thr Pro Leu Val Leu Arg Ser Asp Gly Val Met Gly Glu 
    210                 215                 220                 


Tyr Glu Pro Lys Ile Glu Val Gln Phe Pro Glu Thr Leu Pro Ala Ala 
225                 230                 235                 240 


Lys Gly Ser Thr Val Lys Leu Glu Cys Phe Ala Leu Gly Asn Pro Ile 
                245                 250                 255     


Pro Gln Ile Asn Trp Arg Arg Ser Asp Gly Leu Pro Phe Ser Ser Lys 
            260                 265                 270         


Ile Lys Leu Arg Lys Phe Ser Gly Val Leu Glu Ile Pro Asn Phe Gln 
        275                 280                 285             


Gln Glu Asp Ala Gly Ser Tyr Glu Cys Ile Ala Glu Asn Ser Arg Gly 
    290                 295                 300                 


Lys Asn Val Ala Arg Gly Arg Leu Thr Tyr Tyr Ala Lys Pro His Trp 
305                 310                 315                 320 


Val Gln Leu Ile Lys Asp Val Glu Ile Ala Val Glu Asp Ser Leu Tyr 
                325                 330                 335     


Trp Glu Cys Arg Ala Ser Gly Lys Pro Lys Pro Ser Tyr Arg Trp Leu 
            340                 345                 350         


Lys Asn Gly Ala Ala Leu Val Leu Glu Glu Arg Thr Gln Ile Glu Asn 
        355                 360                 365             


Gly Ala Leu Thr Ile Ser Asn Leu Ser Val Thr Asp Ser Gly Met Phe 
    370                 375                 380                 


Gln Cys Ile Ala Glu Asn Lys His Gly Leu Val Tyr Ser Ser Ala Glu 
385                 390                 395                 400 


Leu Lys Val Val Ala Ser Ala Pro Asp Phe Ser Lys Asn Pro Met Lys 
                405                 410                 415     


Lys Leu Val Gln Val Gln Val Gly Ser Leu Val Ser Leu Asp Cys Lys 
            420                 425                 430         


Pro Arg Ala Ser Pro Arg Ala Leu Ser Ser Trp Lys Lys Gly Asp Val 
        435                 440                 445             


Ser Val Gln Glu His Glu Arg Ile Ser Leu Leu Asn Asp Gly Gly Leu 
    450                 455                 460                 


Lys Ile Ala Asn Val Thr Lys Ala Asp Ala Gly Thr Tyr Thr Cys Met 
465                 470                 475                 480 


Ala Glu Asn Gln Phe Gly Lys Ala Asn Gly Thr Thr His Leu Val Val 
                485                 490                 495     


Thr Glu Pro Thr Arg Ile Thr Leu Ala Pro Ser Asn Met Asp Val Ser 
            500                 505                 510         


Val Gly Glu Ser Val Ile Leu Pro Cys Gln Val Gln His Asp Pro Leu 
        515                 520                 525             


Leu Asp Ile Ile Phe Thr Trp Tyr Phe Asn Gly Ala Leu Ala Asp Phe 
    530                 535                 540                 


Lys Lys Asp Gly Ser His Phe Glu Lys Val Gly Gly Ser Ser Ser Gly 
545                 550                 555                 560 


Asp Leu Met Ile Arg Asn Ile Gln Leu Lys His Ser Gly Lys Tyr Val 
                565                 570                 575     


Cys Met Val Gln Thr Gly Val Asp Ser Val Ser Ser Ala Ala Asp Leu 
            580                 585                 590         


Ile Val Arg Gly Ser Pro Gly Pro Pro Glu Asn Val Lys Val Asp Glu 
        595                 600                 605             


Ile Thr Asp Thr Thr Ala Gln Leu Ser Trp Lys Glu Gly Lys Asp Asn 
    610                 615                 620                 


His Ser Pro Val Ile Ser Tyr Ser Ile Gln Ala Arg Thr Pro Phe Ser 
625                 630                 635                 640 


Val Gly Trp Gln Thr Val Thr Thr Val Pro Glu Val Ile Asp Gly Lys 
                645                 650                 655     


Thr His Thr Ala Thr Val Val Glu Leu Asn Pro Trp Val Glu Tyr Glu 
            660                 665                 670         


Phe Arg Val Val Ala Ser Asn Lys Ile Gly Gly Gly Glu Pro Ser Leu 
        675                 680                 685             


Pro Ser Glu Lys Val Arg Thr Glu Glu Ala Val Pro Glu Val Pro Pro 
    690                 695                 700                 


Ser Glu Val Asn Gly Gly Gly Gly Ser Arg Ser Glu Leu Val Ile Thr 
705                 710                 715                 720 


Trp Asp Pro Val Pro Glu Glu Leu Gln Asn Gly Glu Gly Phe Gly Tyr 
                725                 730                 735     


Val Val Ala Phe Arg Pro Leu Gly Val Thr Thr Trp Ile Gln Thr Val 
            740                 745                 750         


Val Thr Ser Pro Asp Thr Pro Arg Tyr Val Phe Arg Asn Glu Ser Ile 
        755                 760                 765             


Val Pro Tyr Ser Pro Tyr Glu Val Lys Val Gly Val Tyr Asn Asn Lys 
    770                 775                 780                 


Gly Glu Gly Pro Phe Ser Pro Val Thr Thr Val Phe Ser Ala Glu Glu 
785                 790                 795                 800 


Glu Pro Thr Val Ala Pro Ser Gln Val Ser Ala Asn Ser Leu Ser Ser 
                805                 810                 815     


Ser Glu Ile Glu Val Ser Trp Asn Thr Ile Pro Trp Lys Leu Ser Asn 
            820                 825                 830         


Gly His Leu Leu Gly Tyr Glu Val Arg Tyr Trp Asn Gly Gly Gly Lys 
        835                 840                 845             


Glu Glu Ser Ser Ser Lys Met Lys Val Ala Gly Asn Glu Thr Ser Ala 
    850                 855                 860                 


Arg Leu Arg Gly Leu Lys Ser Asn Leu Ala Tyr Tyr Thr Ala Val Arg 
865                 870                 875                 880 


Ala Tyr Asn Ser Ala Gly Ala Gly Pro Phe Ser Ala Thr Val Asn Val 
                885                 890                 895     


Thr Thr Lys Lys Thr Pro Pro Ser Gln Pro Pro Gly Asn Val Val Trp 
            900                 905                 910         


Asn Ala Thr Asp Thr Lys Val Leu Leu Asn Trp Glu Gln Val Lys Ala 
        915                 920                 925             


Met Glu Asn Glu Ser Glu Val Thr Gly Tyr Lys Val Phe Tyr Arg Thr 
    930                 935                 940                 


Ser Ser Gln Asn Asn Val Gln Val Leu Asn Thr Asn Lys Thr Ser Ala 
945                 950                 955                 960 


Glu Leu Val Leu Pro Ile Lys Glu Asp Tyr Ile Ile Glu Val Lys Ala 
                965                 970                 975     


Thr Thr Asp Gly Gly Asp Gly Thr Ser Ser Glu Gln Ile Arg Ile Pro 
            980                 985                 990         


Arg Ile Thr Ser Met Asp Ala Arg  Gly Ser Thr Ser Ala  Ile Ser Asn 
        995                 1000                 1005             


Val His  Pro Met Ser Ser Tyr  Met Pro Ile Val Leu  Phe Leu Ile 
    1010                 1015                 1020             


Val Tyr  Val Leu Trp 
    1025             


<210>  3144
<211>  698
<212>  PRT
<213>  Homo Sapiens

<400>  3144

Met Glu Glu Asn Val Phe Trp Glu Cys Lys Ala Asn Gly Arg Pro Lys 
1               5                   10                  15      


Pro Thr Tyr Lys Trp Leu Lys Asn Gly Glu Pro Leu Leu Thr Arg Asp 
            20                  25                  30          


Arg Ile Gln Ile Glu Gln Gly Thr Leu Asn Ile Thr Ile Val Asn Leu 
        35                  40                  45              


Ser Asp Ala Gly Met Tyr Gln Cys Leu Ala Glu Asn Lys His Gly Val 
    50                  55                  60                  


Ile Phe Ser Asn Ala Glu Leu Ser Val Ile Ala Val Gly Pro Asp Phe 
65                  70                  75                  80  


Ser Arg Thr Leu Leu Lys Arg Val Thr Leu Val Lys Val Gly Gly Glu 
                85                  90                  95      


Val Val Ile Glu Cys Lys Pro Lys Ala Ser Pro Lys Pro Val Tyr Thr 
            100                 105                 110         


Trp Lys Lys Gly Arg Asp Ile Leu Lys Glu Asn Glu Arg Ile Thr Ile 
        115                 120                 125             


Ser Glu Asp Gly Asn Leu Arg Ile Ile Asn Val Thr Lys Ser Asp Ala 
    130                 135                 140                 


Gly Ser Tyr Thr Cys Ile Ala Thr Asn His Phe Gly Thr Ala Ser Ser 
145                 150                 155                 160 


Thr Gly Asn Leu Val Val Lys Asp Pro Thr Arg Val Met Val Pro Pro 
                165                 170                 175     


Ser Ser Met Asp Val Thr Val Gly Glu Ser Ile Val Leu Pro Cys Gln 
            180                 185                 190         


Val Thr His Asp His Ser Leu Asp Ile Val Phe Thr Trp Ser Phe Asn 
        195                 200                 205             


Gly His Leu Ile Asp Phe Asp Arg Asp Gly Asp His Phe Glu Arg Val 
    210                 215                 220                 


Gly Gly Gln Asp Ser Ala Gly Asp Leu Met Ile Arg Asn Ile Gln Leu 
225                 230                 235                 240 


Lys His Ala Gly Lys Tyr Val Cys Met Val Gln Thr Ser Val Asp Arg 
                245                 250                 255     


Leu Ser Ala Ala Ala Asp Leu Ile Val Arg Gly Pro Pro Gly Pro Pro 
            260                 265                 270         


Glu Ala Val Thr Ile Asp Glu Ile Thr Asp Thr Thr Ala Gln Leu Ser 
        275                 280                 285             


Trp Arg Pro Gly Pro Asp Asn His Ser Pro Ile Thr Met Tyr Val Ile 
    290                 295                 300                 


Gln Ala Arg Thr Pro Phe Ser Val Gly Trp Gln Ala Val Ser Thr Val 
305                 310                 315                 320 


Pro Glu Leu Ile Asp Gly Lys Thr Phe Thr Ala Thr Val Val Gly Leu 
                325                 330                 335     


Asn Pro Trp Val Glu Tyr Glu Phe Arg Thr Val Ala Ala Asn Val Ile 
            340                 345                 350         


Gly Ile Gly Glu Pro Ser Arg Pro Ser Glu Lys Arg Arg Thr Glu Glu 
        355                 360                 365             


Ala Leu Pro Glu Val Thr Pro Ala Asn Val Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Lys Ser Glu Leu Val Ile Thr Trp Glu Thr Val Pro Glu Glu Leu Gln 
385                 390                 395                 400 


Asn Gly Arg Gly Phe Gly Tyr Val Val Ala Phe Arg Pro Tyr Gly Lys 
                405                 410                 415     


Met Ile Trp Met Leu Thr Val Leu Ala Ser Ala Asp Ala Ser Arg Tyr 
            420                 425                 430         


Val Phe Arg Asn Glu Ser Val His Pro Phe Ser Pro Phe Glu Val Lys 
        435                 440                 445             


Val Gly Val Phe Asn Asn Lys Gly Glu Gly Pro Phe Ser Pro Thr Thr 
    450                 455                 460                 


Val Val Tyr Ser Ala Glu Glu Glu Pro Thr Lys Pro Pro Ala Ser Ile 
465                 470                 475                 480 


Phe Ala Arg Ser Leu Ser Ala Thr Asp Ile Glu Val Phe Trp Ala Ser 
                485                 490                 495     


Pro Leu Glu Lys Asn Arg Gly Arg Ile Gln Gly Tyr Glu Val Lys Tyr 
            500                 505                 510         


Trp Arg His Glu Asp Lys Glu Glu Asn Ala Arg Lys Ile Arg Thr Val 
        515                 520                 525             


Gly Asn Gln Thr Ser Thr Lys Ile Thr Asn Leu Lys Gly Ser Val Leu 
    530                 535                 540                 


Tyr His Leu Ala Val Lys Ala Tyr Asn Ser Ala Gly Thr Gly Pro Ser 
545                 550                 555                 560 


Ser Ala Thr Val Asn Val Thr Thr Arg Lys Pro Pro Pro Ser Gln Pro 
                565                 570                 575     


Pro Gly Asn Ile Ile Trp Asn Ser Ser Asp Ser Lys Ile Ile Leu Asn 
            580                 585                 590         


Trp Asp Gln Val Lys Ala Leu Asp Asn Glu Ser Glu Val Lys Gly Tyr 
        595                 600                 605             


Lys Val Leu Tyr Arg Trp Asn Arg Gln Ser Ser Thr Ser Val Ile Glu 
    610                 615                 620                 


Thr Asn Lys Thr Ser Val Glu Leu Ser Leu Pro Phe Asp Glu Asp Tyr 
625                 630                 635                 640 


Ile Ile Glu Ile Lys Pro Phe Ser Asp Gly Gly Asp Gly Ser Ser Ser 
                645                 650                 655     


Glu Gln Ile Arg Ile Pro Lys Ile Ser Asn Ala Tyr Ala Arg Gly Ser 
            660                 665                 670         


Gly Ala Ser Thr Ser Asn Ala Cys Thr Leu Ser Ala Ile Ser Thr Ile 
        675                 680                 685             


Met Ile Ser Leu Thr Ala Arg Ser Ser Leu 
    690                 695             


<210>  3145
<211>  54
<212>  PRT
<213>  Homo Sapiens

<400>  3145

Met Arg Leu Pro Trp Glu Leu Leu Val Leu Gln Ser Phe Ile Leu Cys 
1               5                   10                  15      


Leu Ala Asp Asp Ser Thr Leu His Gly Pro Ile Phe Ile Gln Glu Pro 
            20                  25                  30          


Ser Pro Val Met Phe Pro Leu Asp Ser Glu Glu Lys Lys Val Lys Leu 
        35                  40                  45              


Asn Cys Glu Val Lys Gly 
    50                  


<210>  3146
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  3146

Met Arg Leu Pro Trp Glu Leu Leu Val Leu Gln Ser Phe Ile Leu Cys 
1               5                   10                  15      


Leu Ala Asp Asp Ser Thr Leu His Gly Pro Ile Phe Ile Gln Glu Pro 
            20                  25                  30          


Ser Pro Val Met Phe Pro Leu Asp Ser Glu Glu Lys Lys Val Lys Leu 
        35                  40                  45              


Asn Cys Glu Val Lys Gly Asn Pro Lys Pro His Ile Arg Trp Lys Leu 
    50                  55                  60                  


Asn Gly Thr Asp Val Asp Thr Gly Met Asp Phe Arg Tyr Ser Val Val 
65                  70                  75                  80  


Glu Gly Ser Leu Leu Ile Asn Asn Pro Asn Lys Thr Gln Asp Ala Gly 
                85                  90                  95      


Thr Tyr Gln Cys Thr Ala Thr Asn Ser Phe Gly Thr Ile Val Ser Arg 
            100                 105                 110         


Glu Ala Lys Leu 
        115     


<210>  3147
<211>  1026
<212>  PRT
<213>  Homo Sapiens

<400>  3147

Met Arg Leu Pro Trp Glu Leu Leu Val Leu Gln Ser Phe Ile Leu Cys 
1               5                   10                  15      


Leu Ala Asp Asp Ser Thr Leu His Gly Pro Ile Phe Ile Gln Glu Pro 
            20                  25                  30          


Ser Pro Val Met Phe Pro Leu Asp Ser Glu Glu Lys Lys Val Lys Leu 
        35                  40                  45              


Asn Cys Glu Val Lys Gly Asn Pro Lys Pro His Ile Arg Trp Lys Leu 
    50                  55                  60                  


Asn Gly Thr Asp Val Asp Thr Gly Met Asp Phe Arg Tyr Ser Val Val 
65                  70                  75                  80  


Glu Gly Ser Leu Leu Ile Asn Asn Pro Asn Lys Thr Gln Asp Ala Gly 
                85                  90                  95      


Thr Tyr Gln Cys Thr Ala Thr Asn Ser Phe Gly Thr Ile Val Ser Arg 
            100                 105                 110         


Glu Ala Lys Leu Gln Phe Ala Tyr Leu Asp Asn Phe Lys Thr Arg Thr 
        115                 120                 125             


Arg Ser Thr Val Ser Val Arg Arg Gly Gln Gly Met Val Leu Leu Cys 
    130                 135                 140                 


Gly Pro Pro Pro His Ser Gly Glu Leu Ser Tyr Ala Trp Ile Phe Asn 
145                 150                 155                 160 


Glu Tyr Pro Ser Tyr Gln Asp Asn Arg Arg Phe Val Ser Gln Glu Thr 
                165                 170                 175     


Gly Asn Leu Tyr Ile Ala Lys Val Glu Lys Ser Asp Val Gly Asn Tyr 
            180                 185                 190         


Thr Cys Val Val Thr Asn Thr Val Thr Asn His Lys Val Leu Gly Pro 
        195                 200                 205             


Pro Thr Pro Leu Ile Leu Arg Asn Asp Gly Val Met Gly Glu Tyr Glu 
    210                 215                 220                 


Pro Lys Ile Glu Val Gln Phe Pro Glu Thr Val Pro Thr Ala Lys Gly 
225                 230                 235                 240 


Ala Thr Val Lys Leu Glu Cys Phe Ala Leu Gly Asn Pro Val Pro Thr 
                245                 250                 255     


Ile Ile Trp Arg Arg Ala Asp Gly Lys Pro Ile Ala Arg Lys Ala Arg 
            260                 265                 270         


Arg His Lys Ser Asn Gly Ile Leu Glu Ile Pro Asn Phe Gln Gln Glu 
        275                 280                 285             


Asp Ala Gly Leu Tyr Glu Cys Val Ala Glu Asn Ser Arg Gly Lys Asn 
    290                 295                 300                 


Val Ala Arg Gly Gln Leu Thr Phe Tyr Ala Gln Pro Asn Trp Ile Gln 
305                 310                 315                 320 


Lys Ile Asn Asp Ile His Val Ala Met Glu Glu Asn Val Phe Trp Glu 
                325                 330                 335     


Cys Lys Ala Asn Gly Arg Pro Lys Pro Thr Tyr Lys Trp Leu Lys Asn 
            340                 345                 350         


Gly Glu Pro Leu Leu Thr Arg Asp Arg Ile Gln Ile Glu Gln Gly Thr 
        355                 360                 365             


Leu Asn Ile Thr Ile Val Asn Leu Ser Asp Ala Gly Met Tyr Gln Cys 
    370                 375                 380                 


Leu Ala Glu Asn Lys His Gly Val Ile Phe Ser Asn Ala Glu Leu Ser 
385                 390                 395                 400 


Val Ile Ala Val Gly Pro Asp Phe Ser Arg Thr Leu Leu Lys Arg Val 
                405                 410                 415     


Thr Leu Val Lys Val Gly Gly Glu Val Val Ile Glu Cys Lys Pro Lys 
            420                 425                 430         


Ala Ser Pro Lys Pro Val Tyr Thr Trp Lys Lys Gly Arg Asp Ile Leu 
        435                 440                 445             


Lys Glu Asn Glu Arg Ile Thr Ile Ser Glu Asp Gly Asn Leu Arg Ile 
    450                 455                 460                 


Ile Asn Val Thr Lys Ser Asp Ala Gly Ser Tyr Thr Cys Ile Ala Thr 
465                 470                 475                 480 


Asn His Phe Gly Thr Ala Ser Ser Thr Gly Asn Leu Val Val Lys Asp 
                485                 490                 495     


Pro Thr Arg Val Met Val Pro Pro Ser Ser Met Asp Val Thr Val Gly 
            500                 505                 510         


Glu Ser Ile Val Leu Pro Cys Gln Val Thr His Asp His Ser Leu Asp 
        515                 520                 525             


Ile Val Phe Thr Trp Ser Phe Asn Gly His Leu Ile Asp Phe Asp Arg 
    530                 535                 540                 


Asp Gly Asp His Phe Glu Arg Val Gly Gly Gln Asp Ser Ala Gly Asp 
545                 550                 555                 560 


Leu Met Ile Arg Asn Ile Gln Leu Lys His Ala Gly Lys Tyr Val Cys 
                565                 570                 575     


Met Val Gln Thr Ser Val Asp Arg Leu Ser Ala Ala Ala Asp Leu Ile 
            580                 585                 590         


Val Arg Gly Pro Pro Gly Pro Pro Glu Ala Val Thr Ile Asp Glu Ile 
        595                 600                 605             


Thr Asp Thr Thr Ala Gln Leu Ser Trp Arg Pro Gly Pro Asp Asn His 
    610                 615                 620                 


Ser Pro Ile Thr Met Tyr Val Ile Gln Ala Arg Thr Pro Phe Ser Val 
625                 630                 635                 640 


Gly Trp Gln Ala Val Ser Thr Val Pro Glu Leu Ile Asp Gly Lys Thr 
                645                 650                 655     


Phe Thr Ala Thr Val Val Gly Leu Asn Pro Trp Val Glu Tyr Glu Phe 
            660                 665                 670         


Arg Thr Val Ala Ala Asn Val Ile Gly Ile Gly Glu Pro Ser Arg Pro 
        675                 680                 685             


Ser Glu Lys Arg Arg Thr Glu Glu Ala Leu Pro Glu Val Thr Pro Ala 
    690                 695                 700                 


Asn Val Ser Gly Gly Gly Gly Ser Lys Ser Glu Leu Val Ile Thr Trp 
705                 710                 715                 720 


Glu Thr Val Pro Glu Glu Leu Gln Asn Gly Arg Gly Phe Gly Tyr Val 
                725                 730                 735     


Val Ala Phe Arg Pro Tyr Gly Lys Met Ile Trp Met Leu Thr Val Leu 
            740                 745                 750         


Ala Ser Ala Asp Ala Ser Arg Tyr Val Phe Arg Asn Glu Ser Val His 
        755                 760                 765             


Pro Phe Ser Pro Phe Glu Val Lys Val Gly Val Phe Asn Asn Lys Gly 
    770                 775                 780                 


Glu Gly Pro Phe Ser Pro Thr Thr Val Val Tyr Ser Ala Glu Glu Glu 
785                 790                 795                 800 


Pro Thr Lys Pro Pro Ala Ser Ile Phe Ala Arg Ser Leu Ser Ala Thr 
                805                 810                 815     


Asp Ile Glu Val Phe Trp Ala Ser Pro Leu Glu Lys Asn Arg Gly Arg 
            820                 825                 830         


Ile Gln Gly Tyr Glu Val Lys Tyr Trp Arg His Glu Asp Lys Glu Glu 
        835                 840                 845             


Asn Ala Arg Lys Ile Arg Thr Val Gly Asn Gln Thr Ser Thr Lys Ile 
    850                 855                 860                 


Thr Asn Leu Lys Gly Ser Val Leu Tyr His Leu Ala Val Lys Ala Tyr 
865                 870                 875                 880 


Asn Ser Ala Gly Thr Gly Pro Ser Ser Ala Thr Val Asn Val Thr Thr 
                885                 890                 895     


Arg Lys Pro Pro Pro Ser Gln Pro Pro Gly Asn Ile Ile Trp Asn Ser 
            900                 905                 910         


Ser Asp Ser Lys Ile Ile Leu Asn Trp Asp Gln Val Lys Ala Leu Asp 
        915                 920                 925             


Asn Glu Ser Glu Val Lys Gly Tyr Lys Val Leu Tyr Arg Trp Asn Arg 
    930                 935                 940                 


Gln Ser Ser Thr Ser Val Ile Glu Thr Asn Lys Thr Ser Val Glu Leu 
945                 950                 955                 960 


Ser Leu Pro Phe Asp Glu Asp Tyr Ile Ile Glu Ile Lys Pro Phe Ser 
                965                 970                 975     


Asp Gly Gly Asp Gly Ser Ser Ser Glu Gln Ile Arg Ile Pro Lys Ile 
            980                 985                 990         


Ser Asn Ala Tyr Ala Arg Gly Ser  Gly Ala Ser Thr Ser  Asn Ala Cys 
        995                 1000                 1005             


Thr Leu  Ser Ala Ile Ser Thr  Ile Met Ile Ser Leu  Thr Ala Arg 
    1010                 1015                 1020             


Ser Ser  Leu 
    1025     


<210>  3148
<211>  1026
<212>  PRT
<213>  Homo Sapiens

<400>  3148

Met Arg Leu Pro Trp Glu Leu Leu Val Leu Gln Ser Phe Ile Leu Cys 
1               5                   10                  15      


Leu Ala Asp Asp Ser Thr Leu His Gly Pro Ile Phe Ile Gln Glu Pro 
            20                  25                  30          


Ser Pro Val Met Phe Pro Leu Asp Ser Glu Glu Lys Lys Val Lys Leu 
        35                  40                  45              


Asn Cys Glu Val Lys Gly Asn Pro Lys Pro His Ile Arg Trp Lys Leu 
    50                  55                  60                  


Asn Gly Thr Asp Val Asp Thr Gly Met Asp Phe Arg Tyr Ser Val Val 
65                  70                  75                  80  


Glu Gly Ser Leu Leu Ile Asn Asn Pro Asn Lys Thr Gln Asp Ala Gly 
                85                  90                  95      


Thr Tyr Gln Cys Thr Ala Thr Asn Ser Phe Gly Thr Ile Val Ser Arg 
            100                 105                 110         


Glu Ala Lys Leu Gln Phe Ala Tyr Leu Asp Asn Phe Lys Thr Arg Thr 
        115                 120                 125             


Arg Ser Thr Val Ser Val Arg Arg Gly Gln Gly Met Val Leu Leu Cys 
    130                 135                 140                 


Gly Pro Pro Pro His Ser Gly Glu Leu Ser Tyr Ala Trp Ile Phe Asn 
145                 150                 155                 160 


Glu Tyr Pro Ser Tyr Gln Asp Asn Arg Arg Phe Val Ser Gln Glu Thr 
                165                 170                 175     


Gly Asn Leu Tyr Ile Ala Lys Val Glu Lys Ser Asp Val Gly Asn Tyr 
            180                 185                 190         


Thr Cys Val Val Thr Asn Thr Val Thr Asn His Lys Val Leu Gly Pro 
        195                 200                 205             


Pro Thr Pro Leu Ile Leu Arg Asn Asp Gly Val Met Gly Glu Tyr Glu 
    210                 215                 220                 


Pro Lys Ile Glu Val Gln Phe Pro Glu Thr Val Pro Thr Ala Lys Gly 
225                 230                 235                 240 


Ala Thr Val Lys Leu Glu Cys Phe Ala Leu Gly Asn Pro Val Pro Thr 
                245                 250                 255     


Ile Ile Trp Arg Arg Ala Asp Gly Lys Pro Ile Ala Arg Lys Ala Arg 
            260                 265                 270         


Arg His Lys Ser Asn Gly Ile Leu Glu Ile Pro Asn Phe Gln Gln Glu 
        275                 280                 285             


Asp Ala Gly Leu Tyr Glu Cys Val Ala Glu Asn Ser Arg Gly Lys Asn 
    290                 295                 300                 


Val Ala Arg Gly Gln Leu Thr Phe Tyr Ala Gln Pro Asn Trp Ile Gln 
305                 310                 315                 320 


Lys Ile Asn Asp Ile His Val Ala Met Glu Glu Asn Val Phe Trp Glu 
                325                 330                 335     


Cys Lys Ala Asn Gly Arg Pro Lys Pro Thr Tyr Lys Trp Leu Lys Asn 
            340                 345                 350         


Gly Glu Pro Leu Leu Thr Arg Asp Arg Ile Gln Ile Glu Gln Gly Thr 
        355                 360                 365             


Leu Asn Ile Thr Ile Val Asn Leu Ser Asp Ala Gly Met Tyr Gln Cys 
    370                 375                 380                 


Leu Ala Glu Asn Lys His Gly Val Ile Phe Ser Asn Ala Glu Leu Ser 
385                 390                 395                 400 


Val Ile Ala Val Gly Pro Asp Phe Ser Arg Thr Leu Leu Lys Arg Val 
                405                 410                 415     


Thr Leu Val Lys Val Gly Gly Glu Val Val Ile Glu Cys Lys Pro Lys 
            420                 425                 430         


Ala Ser Pro Lys Pro Val Tyr Thr Trp Lys Lys Gly Arg Asp Ile Leu 
        435                 440                 445             


Lys Glu Asn Glu Arg Ile Thr Ile Ser Glu Asp Gly Asn Leu Arg Ile 
    450                 455                 460                 


Ile Asn Val Thr Lys Ser Asp Ala Gly Ser Tyr Thr Cys Ile Ala Thr 
465                 470                 475                 480 


Asn His Phe Gly Thr Ala Ser Ser Thr Gly Asn Leu Val Val Lys Asp 
                485                 490                 495     


Pro Thr Arg Val Met Val Pro Pro Ser Ser Met Asp Val Thr Val Gly 
            500                 505                 510         


Glu Ser Ile Val Leu Pro Cys Gln Val Thr His Asp His Ser Leu Asp 
        515                 520                 525             


Ile Val Phe Thr Trp Ser Phe Asn Gly His Leu Ile Asp Phe Asp Arg 
    530                 535                 540                 


Asp Gly Asp His Phe Glu Arg Val Gly Gly Gln Asp Ser Ala Gly Asp 
545                 550                 555                 560 


Leu Met Ile Arg Asn Ile Gln Leu Lys His Ala Gly Lys Tyr Val Cys 
                565                 570                 575     


Met Val Gln Thr Ser Val Asp Arg Leu Ser Ala Ala Ala Asp Leu Ile 
            580                 585                 590         


Val Arg Gly Pro Pro Gly Pro Pro Glu Ala Val Thr Ile Asp Glu Ile 
        595                 600                 605             


Thr Asp Thr Thr Ala Gln Leu Ser Trp Arg Pro Gly Pro Asp Asn His 
    610                 615                 620                 


Ser Pro Ile Thr Met Tyr Val Ile Gln Ala Arg Thr Pro Phe Ser Val 
625                 630                 635                 640 


Gly Trp Gln Ala Val Ser Thr Val Pro Glu Leu Ile Asp Gly Lys Thr 
                645                 650                 655     


Phe Thr Ala Thr Val Val Gly Leu Asn Pro Trp Val Glu Tyr Glu Phe 
            660                 665                 670         


Arg Thr Val Ala Ala Asn Val Ile Gly Ile Gly Glu Pro Ser Arg Pro 
        675                 680                 685             


Ser Glu Lys Arg Arg Thr Glu Glu Ala Leu Pro Glu Val Thr Pro Ala 
    690                 695                 700                 


Asn Val Ser Gly Gly Gly Gly Ser Lys Ser Glu Leu Val Ile Thr Trp 
705                 710                 715                 720 


Glu Thr Val Pro Glu Glu Leu Gln Asn Gly Arg Gly Phe Gly Tyr Val 
                725                 730                 735     


Val Ala Phe Arg Pro Tyr Gly Lys Met Ile Trp Met Leu Thr Val Leu 
            740                 745                 750         


Ala Ser Ala Asp Ala Ser Arg Tyr Val Phe Arg Asn Glu Ser Val His 
        755                 760                 765             


Pro Phe Ser Pro Phe Glu Val Lys Val Gly Val Phe Asn Asn Lys Gly 
    770                 775                 780                 


Glu Gly Pro Phe Ser Pro Thr Thr Val Val Tyr Ser Ala Glu Glu Glu 
785                 790                 795                 800 


Pro Thr Lys Pro Pro Ala Ser Ile Phe Ala Arg Ser Leu Ser Ala Thr 
                805                 810                 815     


Asp Ile Glu Val Phe Trp Ala Ser Pro Leu Glu Lys Asn Arg Gly Arg 
            820                 825                 830         


Ile Gln Gly Tyr Glu Val Lys Tyr Trp Arg His Glu Asp Lys Glu Glu 
        835                 840                 845             


Asn Ala Arg Lys Ile Arg Thr Val Gly Asn Gln Thr Ser Thr Lys Ile 
    850                 855                 860                 


Thr Asn Leu Lys Gly Ser Val Leu Tyr His Leu Ala Val Lys Ala Tyr 
865                 870                 875                 880 


Asn Ser Ala Gly Thr Gly Pro Ser Ser Ala Thr Val Asn Val Thr Thr 
                885                 890                 895     


Arg Lys Pro Pro Pro Ser Gln Pro Pro Gly Asn Ile Ile Trp Asn Ser 
            900                 905                 910         


Ser Asp Ser Lys Ile Ile Leu Asn Trp Asp Gln Val Lys Ala Leu Asp 
        915                 920                 925             


Asn Glu Ser Glu Val Lys Gly Tyr Lys Val Leu Tyr Arg Trp Asn Arg 
    930                 935                 940                 


Gln Ser Ser Thr Ser Val Ile Glu Thr Asn Lys Thr Ser Val Glu Leu 
945                 950                 955                 960 


Ser Leu Pro Phe Asp Glu Asp Tyr Ile Ile Glu Ile Lys Pro Phe Ser 
                965                 970                 975     


Asp Gly Gly Asp Gly Ser Ser Ser Glu Gln Ile Arg Ile Pro Lys Ile 
            980                 985                 990         


Ser Asn Ala Tyr Ala Arg Gly Ser  Gly Ala Ser Thr Ser  Asn Ala Cys 
        995                 1000                 1005             


Thr Leu  Ser Ala Ile Ser Thr  Ile Met Ile Ser Leu  Thr Ala Arg 
    1010                 1015                 1020             


Ser Ser  Leu 
    1025     


<210>  3149
<211>  1026
<212>  PRT
<213>  Homo Sapiens

<400>  3149

Met Arg Leu Pro Trp Glu Leu Leu Val Leu Gln Ser Phe Ile Leu Cys 
1               5                   10                  15      


Leu Ala Asp Asp Ser Thr Leu His Gly Pro Ile Phe Ile Gln Glu Pro 
            20                  25                  30          


Ser Pro Val Met Phe Pro Leu Asp Ser Glu Glu Lys Lys Val Lys Leu 
        35                  40                  45              


Asn Cys Glu Val Lys Gly Asn Pro Lys Pro His Ile Arg Trp Lys Leu 
    50                  55                  60                  


Asn Gly Thr Asp Val Asp Thr Gly Met Asp Phe Arg Tyr Ser Val Val 
65                  70                  75                  80  


Glu Gly Ser Leu Leu Ile Asn Asn Pro Asn Lys Thr Gln Asp Ala Gly 
                85                  90                  95      


Thr Tyr Gln Cys Thr Ala Thr Asn Ser Phe Gly Thr Ile Val Ser Arg 
            100                 105                 110         


Glu Ala Lys Leu Gln Phe Ala Tyr Leu Asp Asn Phe Lys Thr Arg Thr 
        115                 120                 125             


Arg Ser Thr Val Ser Val Arg Arg Gly Gln Gly Met Val Leu Leu Cys 
    130                 135                 140                 


Gly Pro Pro Pro His Ser Gly Glu Leu Ser Tyr Ala Trp Ile Phe Asn 
145                 150                 155                 160 


Glu Tyr Pro Ser Tyr Gln Asp Asn Arg Arg Phe Val Ser Gln Glu Thr 
                165                 170                 175     


Gly Asn Leu Tyr Ile Ala Lys Val Glu Lys Ser Asp Val Gly Asn Tyr 
            180                 185                 190         


Thr Cys Val Val Thr Asn Thr Val Thr Asn His Lys Val Leu Gly Pro 
        195                 200                 205             


Pro Thr Pro Leu Ile Leu Arg Asn Asp Gly Val Met Gly Glu Tyr Glu 
    210                 215                 220                 


Pro Lys Ile Glu Val Gln Phe Pro Glu Thr Val Pro Thr Ala Lys Gly 
225                 230                 235                 240 


Ala Thr Val Lys Leu Glu Cys Phe Ala Leu Gly Asn Pro Val Pro Thr 
                245                 250                 255     


Ile Ile Trp Arg Arg Ala Asp Gly Lys Pro Ile Ala Arg Lys Ala Arg 
            260                 265                 270         


Arg His Lys Ser Asn Gly Ile Leu Glu Ile Pro Asn Phe Gln Gln Glu 
        275                 280                 285             


Asp Ala Gly Leu Tyr Glu Cys Val Ala Glu Asn Ser Arg Gly Lys Asn 
    290                 295                 300                 


Val Ala Arg Gly Gln Leu Thr Phe Tyr Ala Gln Pro Asn Trp Ile Gln 
305                 310                 315                 320 


Lys Ile Asn Asp Ile His Val Ala Met Glu Glu Asn Val Phe Trp Glu 
                325                 330                 335     


Cys Lys Ala Asn Gly Arg Pro Lys Pro Thr Tyr Lys Trp Leu Lys Asn 
            340                 345                 350         


Gly Glu Pro Leu Leu Thr Arg Asp Arg Ile Gln Ile Glu Gln Gly Thr 
        355                 360                 365             


Leu Asn Ile Thr Ile Val Asn Leu Ser Asp Ala Gly Met Tyr Gln Cys 
    370                 375                 380                 


Leu Ala Glu Asn Lys His Gly Val Ile Phe Ser Asn Ala Glu Leu Ser 
385                 390                 395                 400 


Val Ile Ala Val Gly Pro Asp Phe Ser Arg Thr Leu Leu Lys Arg Val 
                405                 410                 415     


Thr Leu Val Lys Val Gly Gly Glu Val Val Ile Glu Cys Lys Pro Lys 
            420                 425                 430         


Ala Ser Pro Lys Pro Val Tyr Thr Trp Lys Lys Gly Arg Asp Ile Leu 
        435                 440                 445             


Lys Glu Asn Glu Arg Ile Thr Ile Ser Glu Asp Gly Asn Leu Arg Ile 
    450                 455                 460                 


Ile Asn Val Thr Lys Ser Asp Ala Gly Ser Tyr Thr Cys Ile Ala Thr 
465                 470                 475                 480 


Asn His Phe Gly Thr Ala Ser Ser Thr Gly Asn Leu Val Val Lys Asp 
                485                 490                 495     


Pro Thr Arg Val Met Val Pro Pro Ser Ser Met Asp Val Thr Val Gly 
            500                 505                 510         


Glu Ser Ile Val Leu Pro Cys Gln Val Thr His Asp His Ser Leu Asp 
        515                 520                 525             


Ile Val Phe Thr Trp Ser Phe Asn Gly His Leu Ile Asp Phe Asp Arg 
    530                 535                 540                 


Asp Gly Asp His Phe Glu Arg Val Gly Gly Gln Asp Ser Ala Gly Asp 
545                 550                 555                 560 


Leu Met Ile Arg Asn Ile Gln Leu Lys His Ala Gly Lys Tyr Val Cys 
                565                 570                 575     


Met Val Gln Thr Ser Val Asp Arg Leu Ser Ala Ala Ala Asp Leu Ile 
            580                 585                 590         


Val Arg Gly Pro Pro Gly Pro Pro Glu Ala Val Thr Ile Asp Glu Ile 
        595                 600                 605             


Thr Asp Thr Thr Ala Gln Leu Ser Trp Arg Pro Gly Pro Asp Asn His 
    610                 615                 620                 


Ser Pro Ile Thr Met Tyr Val Ile Gln Ala Arg Thr Pro Phe Ser Val 
625                 630                 635                 640 


Gly Trp Gln Ala Val Ser Thr Val Pro Glu Leu Ile Asp Gly Lys Thr 
                645                 650                 655     


Phe Thr Ala Thr Val Val Gly Leu Asn Pro Trp Val Glu Tyr Glu Phe 
            660                 665                 670         


Arg Thr Val Ala Ala Asn Val Ile Gly Ile Gly Glu Pro Ser Arg Pro 
        675                 680                 685             


Ser Glu Lys Arg Arg Thr Glu Glu Ala Leu Pro Glu Val Thr Pro Ala 
    690                 695                 700                 


Asn Val Ser Gly Gly Gly Gly Ser Lys Ser Glu Leu Val Ile Thr Trp 
705                 710                 715                 720 


Glu Thr Val Pro Glu Glu Leu Gln Asn Gly Arg Gly Phe Gly Tyr Val 
                725                 730                 735     


Val Ala Phe Arg Pro Tyr Gly Lys Met Ile Trp Met Leu Thr Val Leu 
            740                 745                 750         


Ala Ser Ala Asp Ala Ser Arg Tyr Val Phe Arg Asn Glu Ser Val His 
        755                 760                 765             


Pro Phe Ser Pro Phe Glu Val Lys Val Gly Val Phe Asn Asn Lys Gly 
    770                 775                 780                 


Glu Gly Pro Phe Ser Pro Thr Thr Val Val Tyr Ser Ala Glu Glu Glu 
785                 790                 795                 800 


Pro Thr Lys Pro Pro Ala Ser Ile Phe Ala Arg Ser Leu Ser Ala Thr 
                805                 810                 815     


Asp Ile Glu Val Phe Trp Ala Ser Pro Leu Glu Lys Asn Arg Gly Arg 
            820                 825                 830         


Ile Gln Gly Tyr Glu Val Lys Tyr Trp Arg His Glu Asp Lys Glu Glu 
        835                 840                 845             


Asn Ala Arg Lys Ile Arg Thr Val Gly Asn Gln Thr Ser Thr Lys Ile 
    850                 855                 860                 


Thr Asn Leu Lys Gly Ser Val Leu Tyr His Leu Ala Val Lys Ala Tyr 
865                 870                 875                 880 


Asn Ser Ala Gly Thr Gly Pro Ser Ser Ala Thr Val Asn Val Thr Thr 
                885                 890                 895     


Arg Lys Pro Pro Pro Ser Gln Pro Pro Gly Asn Ile Ile Trp Asn Ser 
            900                 905                 910         


Ser Asp Ser Lys Ile Ile Leu Asn Trp Asp Gln Val Lys Ala Leu Asp 
        915                 920                 925             


Asn Glu Ser Glu Val Lys Gly Tyr Lys Val Leu Tyr Arg Trp Asn Arg 
    930                 935                 940                 


Gln Ser Ser Thr Ser Val Ile Glu Thr Asn Lys Thr Ser Val Glu Leu 
945                 950                 955                 960 


Ser Leu Pro Phe Asp Glu Asp Tyr Ile Ile Glu Ile Lys Pro Phe Ser 
                965                 970                 975     


Asp Gly Gly Asp Gly Ser Ser Ser Glu Gln Ile Arg Ile Pro Lys Ile 
            980                 985                 990         


Ser Asn Ala Tyr Ala Arg Gly Ser  Gly Ala Ser Thr Ser  Asn Ala Cys 
        995                 1000                 1005             


Thr Leu  Ser Ala Ile Ser Thr  Ile Met Ile Ser Leu  Thr Ala Arg 
    1010                 1015                 1020             


Ser Ser  Leu 
    1025     


<210>  3150
<211>  232
<212>  PRT
<213>  Homo Sapiens

<400>  3150

Met Arg Leu Pro Trp Glu Leu Leu Val Leu Gln Ser Phe Ile Leu Cys 
1               5                   10                  15      


Leu Ala Asp Asp Ser Thr Leu His Gly Pro Ile Phe Ile Gln Glu Pro 
            20                  25                  30          


Ser Pro Val Met Phe Pro Leu Asp Ser Glu Glu Lys Lys Val Lys Leu 
        35                  40                  45              


Asn Cys Glu Val Lys Gly Asn Pro Lys Pro His Ile Arg Trp Lys Leu 
    50                  55                  60                  


Asn Gly Thr Asp Val Asp Thr Gly Met Asp Phe Arg Tyr Ser Val Val 
65                  70                  75                  80  


Glu Gly Ser Leu Leu Ile Asn Asn Pro Asn Lys Thr Gln Asp Ala Gly 
                85                  90                  95      


Thr Tyr Gln Cys Thr Ala Thr Asn Ser Phe Gly Thr Ile Val Ser Arg 
            100                 105                 110         


Glu Ala Lys Leu Gln Phe Ala Tyr Leu Asp Asn Phe Lys Thr Arg Thr 
        115                 120                 125             


Arg Ser Thr Val Ser Val Arg Arg Gly Gln Gly Met Val Leu Leu Cys 
    130                 135                 140                 


Gly Pro Pro Pro His Ser Gly Glu Leu Ser Tyr Ala Trp Ile Phe Asn 
145                 150                 155                 160 


Glu Tyr Pro Ser Tyr Gln Asp Asn Arg Arg Phe Val Ser Gln Glu Thr 
                165                 170                 175     


Gly Asn Leu Tyr Ile Ala Lys Val Glu Lys Ser Asp Val Gly Asn Tyr 
            180                 185                 190         


Thr Cys Val Val Thr Asn Thr Val Thr Asn His Lys Val Leu Gly Pro 
        195                 200                 205             


Pro Thr Pro Leu Ile Leu Arg Asn Asp Val Gln Tyr Gln Leu Leu Ser 
    210                 215                 220                 


Gly Glu Glu Leu Met Glu Ser Gln 
225                 230         


<210>  3151
<211>  137
<212>  PRT
<213>  Homo Sapiens

<400>  3151

Met Arg Leu Pro Trp Glu Leu Leu Val Leu Gln Ser Phe Ile Leu Cys 
1               5                   10                  15      


Leu Ala Gly Ser Gln Thr Asp Phe Trp Ser Leu Leu Gly Val Leu Pro 
            20                  25                  30          


Ala Leu Glu Ala Asp Asp Ser Thr Leu His Gly Pro Ile Phe Ile Gln 
        35                  40                  45              


Glu Pro Ser Pro Val Met Phe Pro Leu Asp Ser Glu Glu Lys Lys Val 
    50                  55                  60                  


Lys Leu Asn Cys Glu Val Lys Gly Asn Pro Lys Pro His Ile Arg Trp 
65                  70                  75                  80  


Lys Leu Asn Gly Thr Asp Val Asp Thr Gly Met Asp Phe Arg Tyr Ser 
                85                  90                  95      


Val Val Glu Gly Ser Leu Leu Ile Asn Asn Pro Asn Lys Thr Gln Asp 
            100                 105                 110         


Ala Gly Thr Tyr Gln Cys Thr Ala Thr Asn Ser Phe Gly Thr Ile Val 
        115                 120                 125             


Ser Arg Glu Ala Lys Leu Gln Phe Ala 
    130                 135         


<210>  3152
<211>  143
<212>  PRT
<213>  Homo Sapiens

<400>  3152

Asn Asp Ile His Val Ala Met Glu Glu Asn Val Phe Trp Glu Cys Lys 
1               5                   10                  15      


Ala Asn Gly Arg Pro Lys Pro Thr Tyr Lys Trp Leu Lys Asn Gly Glu 
            20                  25                  30          


Pro Leu Leu Thr Arg Asp Arg Ile Gln Ile Glu Gln Gly Thr Leu Asn 
        35                  40                  45              


Ile Thr Ile Val Asn Leu Ser Asp Ala Gly Met Tyr Gln Cys Leu Ala 
    50                  55                  60                  


Glu Asn Lys His Gly Val Ile Phe Ser Asn Ala Glu Leu Ser Val Ile 
65                  70                  75                  80  


Ala Val Gly Pro Asp Phe Ser Arg Thr Leu Leu Lys Arg Val Thr Leu 
                85                  90                  95      


Val Lys Val Gly Gly Glu Val Val Ile Glu Cys Lys Pro Lys Ala Ser 
            100                 105                 110         


Pro Lys Pro Val Tyr Thr Trp Lys Lys Gly Arg Asp Ile Leu Lys Glu 
        115                 120                 125             


Asn Glu Ser Val His Gln Gly Phe Gly Ser Gly Ser Ala Pro Leu 
    130                 135                 140             


<210>  3153
<211>  1022
<212>  PRT
<213>  Homo Sapiens

<400>  3153

Ala Ser Leu Arg Lys Phe Lys Met Cys Leu Phe Cys Leu Thr Glu Ser 
1               5                   10                  15      


Val Asp Tyr Gly Pro Val Phe Val Gln Glu Pro Asp Asp Ile Ile Phe 
            20                  25                  30          


Pro Thr Asp Ser Asp Glu Lys Lys Val Ala Leu Asn Cys Glu Val Arg 
        35                  40                  45              


Gly Asn Pro Val Pro Ser Tyr Arg Trp Leu Arg Asn Gly Thr Glu Ile 
    50                  55                  60                  


Asp Leu Glu Ser Asp Tyr Arg Tyr Ser Leu Ile Asp Gly Thr Phe Ile 
65                  70                  75                  80  


Ile Ser Asn Pro Ser Glu Ala Lys Asp Ser Gly His Tyr Gln Cys Leu 
                85                  90                  95      


Ala Thr Asn Thr Val Gly Ser Ile Leu Ser Arg Glu Ala Thr Leu Gln 
            100                 105                 110         


Phe Ala Tyr Leu Gly Asn Phe Ser Gly Arg Thr Arg Ser Ala Val Ser 
        115                 120                 125             


Val Arg Glu Gly Gln Gly Val Val Leu Met Cys Ser Pro Pro Pro His 
    130                 135                 140                 


Ser Pro Glu Ile Ile Tyr Ser Trp Val Phe Asn Glu Phe Pro Ser Phe 
145                 150                 155                 160 


Val Ala Glu Asp Ser Arg Arg Phe Ile Ser Gln Glu Thr Gly Asn Leu 
                165                 170                 175     


Tyr Ile Ser Lys Val Gln Thr Ser Asp Val Gly Ser Tyr Ile Cys Leu 
            180                 185                 190         


Val Lys Asn Thr Val Thr Asn Ala Arg Val Leu Ser Pro Pro Thr Pro 
        195                 200                 205             


Leu Thr Leu Arg Asn Asp Gly Val Met Gly Glu Tyr Glu Pro Lys Ile 
    210                 215                 220                 


Glu Val His Phe Pro Phe Thr Val Thr Ala Ala Lys Gly Thr Thr Val 
225                 230                 235                 240 


Lys Met Glu Cys Phe Ala Leu Gly Asn Pro Val Pro Thr Ile Thr Trp 
                245                 250                 255     


Met Lys Val Asn Gly Tyr Ile Pro Ser Lys Ala Arg Leu Arg Lys Ser 
            260                 265                 270         


Gln Ala Val Leu Glu Ile Pro Asn Val Gln Leu Asp Asp Ala Gly Ile 
        275                 280                 285             


Tyr Glu Cys Arg Ala Glu Asn Ser Arg Gly Lys Asn Ser Phe Arg Gly 
    290                 295                 300                 


Gln Leu Gln Val Tyr Thr Tyr Pro His Trp Val Glu Lys Leu Asn Asp 
305                 310                 315                 320 


Thr Gln Leu Asp Ser Gly Ser Pro Leu Arg Trp Glu Cys Lys Ala Thr 
                325                 330                 335     


Gly Lys Pro Arg Pro Thr Tyr Arg Trp Leu Lys Asn Gly Val Pro Leu 
            340                 345                 350         


Ser Pro Gln Ser Arg Val Glu Met Val Asn Gly Val Leu Met Ile His 
        355                 360                 365             


Asn Val Asn Gln Ser Asp Ala Gly Met Tyr Gln Cys Leu Ala Glu Asn 
    370                 375                 380                 


Lys Tyr Gly Ala Ile Tyr Ala Ser Ala Glu Leu Lys Ile Leu Ala Ser 
385                 390                 395                 400 


Ala Pro Thr Phe Ala Leu Asn Gln Leu Lys Lys Thr Ile Ile Val Thr 
                405                 410                 415     


Lys Asp Gln Glu Val Val Ile Glu Cys Lys Pro Gln Gly Ser Pro Lys 
            420                 425                 430         


Pro Thr Ile Ser Trp Lys Lys Gly Asp Arg Ala Val Arg Glu Asn Lys 
        435                 440                 445             


Arg Ile Ala Ile Leu Pro Asp Gly Ser Leu Arg Ile Leu Asn Ala Ser 
    450                 455                 460                 


Lys Ser Asp Glu Gly Lys Tyr Val Cys Arg Gly Glu Asn Val Phe Gly 
465                 470                 475                 480 


Ser Ala Glu Ile Ile Ala Ser Leu Ser Val Lys Glu Pro Thr Arg Ile 
                485                 490                 495     


Glu Leu Thr Pro Lys Arg Thr Glu Leu Thr Val Gly Glu Ser Ile Val 
            500                 505                 510         


Leu Asn Cys Lys Ala Ile His Asp Ala Ser Leu Asp Val Thr Phe Tyr 
        515                 520                 525             


Trp Thr Leu Lys Gly Gln Pro Ile Asp Phe Glu Glu Glu Gly Gly His 
    530                 535                 540                 


Phe Glu Ser Ile Arg Ala Gln Ala Ser Ser Ala Asp Leu Met Ile Arg 
545                 550                 555                 560 


Asn Ile Leu Leu Met His Ala Gly Arg Tyr Gly Cys Arg Val Gln Thr 
                565                 570                 575     


Thr Ala Asp Ser Val Ser Asp Glu Ala Glu Leu Leu Val Arg Gly Pro 
            580                 585                 590         


Pro Gly Pro Pro Gly Ile Val Ile Val Glu Glu Ile Thr Glu Ser Thr 
        595                 600                 605             


Ala Thr Leu Ser Trp Ser Pro Ala Ala Asp Asn His Ser Pro Ile Ser 
    610                 615                 620                 


Ser Tyr Asn Leu Gln Ala Arg Ser Pro Phe Ser Leu Gly Trp Gln Thr 
625                 630                 635                 640 


Val Lys Thr Val Pro Glu Ile Ile Thr Gly Asp Met Glu Ser Ala Met 
                645                 650                 655     


Ala Val Asp Leu Asn Pro Trp Val Glu Tyr Glu Phe Arg Val Val Ala 
            660                 665                 670         


Thr Asn Pro Ile Gly Thr Gly Asp Pro Ser Thr Pro Ser Arg Met Ile 
        675                 680                 685             


Arg Thr Asn Glu Ala Val Pro Lys Thr Ala Pro Thr Asn Val Ser Gly 
    690                 695                 700                 


Arg Ser Gly Arg Arg His Glu Leu Val Ile Ala Trp Glu Pro Val Ser 
705                 710                 715                 720 


Glu Glu Phe Gln Asn Gly Glu Gly Phe Gly Tyr Ile Val Ala Phe Arg 
                725                 730                 735     


Pro Asn Gly Thr Arg Gly Trp Lys Glu Lys Met Val Thr Ser Ser Glu 
            740                 745                 750         


Ala Ser Lys Phe Ile Tyr Arg Asp Glu Ser Val Pro Pro Leu Thr Pro 
        755                 760                 765             


Phe Glu Val Lys Val Gly Val Tyr Asn Asn Lys Gly Asp Gly Pro Phe 
    770                 775                 780                 


Ser Gln Ile Val Val Ile Cys Ser Ala Glu Gly Glu Pro Ser Ala Ala 
785                 790                 795                 800 


Pro Thr Asp Val Lys Ala Thr Ser Val Ser Val Ser Glu Ile Leu Val 
                805                 810                 815     


Ala Trp Lys His Ile Lys Glu Ser Leu Gly Arg Pro Gln Gly Phe Glu 
            820                 825                 830         


Val Gly Tyr Trp Lys Asp Met Glu Gln Glu Asp Thr Ala Glu Thr Val 
        835                 840                 845             


Lys Thr Arg Gly Asn Glu Ser Phe Val Ile Leu Thr Gly Leu Glu Gly 
    850                 855                 860                 


Asn Thr Leu Tyr His Phe Thr Val Arg Ala Tyr Asn Gly Ala Gly Tyr 
865                 870                 875                 880 


Gly Pro Pro Ser Ser Glu Val Ser Ala Thr Thr Lys Lys Ser Pro Pro 
                885                 890                 895     


Ser Gln Ala Pro Ser Asn Leu Arg Trp Glu Gln Gln Gly Ser Gln Val 
            900                 905                 910         


Ser Leu Gly Trp Glu Pro Val Ile Pro Leu Ala Asn Glu Ser Glu Val 
        915                 920                 925             


Val Gly Tyr Lys Val Phe Tyr Arg Gln Glu Gly His Ser Asn Ser Gln 
    930                 935                 940                 


Val Ile Glu Thr Gln Lys Leu Gln Ala Val Val Pro Leu Pro Asp Ala 
945                 950                 955                 960 


Gly Val Tyr Ile Ile Glu Val Arg Ala Tyr Ser Glu Gly Gly Asp Gly 
                965                 970                 975     


Thr Ala Ser Ser Gln Ile Arg Val Pro Ser Tyr Ser Gly Gly Lys Ile 
            980                 985                 990         


Thr Ser Ala Gln Ser Thr Leu His  Ser Leu Ser Thr Ser  Ser Ser Ser 
        995                 1000                 1005             


Val Thr  Leu Leu Leu Ala Leu  Met Ile Pro Ser Thr  Ser Trp 
    1010                 1015                 1020         


<210>  3154
<211>  1084
<212>  PRT
<213>  Homo Sapiens

<400>  3154

Leu Thr Glu Tyr Ser Lys Ser Leu Pro Gly Leu Ser Thr Ser Tyr Ala 
1               5                   10                  15      


Ala Leu Leu Arg Ile Lys Lys Ser Ser Ser Ser Ser Leu Phe Gly Ser 
            20                  25                  30          


Lys Thr Arg Pro Arg Tyr Ser Ser Pro Ser Leu Gly Thr Leu Ser Ala 
        35                  40                  45              


Ser Ser Pro Ser Trp Leu Gly Ala Ala Gln Asn Tyr Tyr Ser Pro Ile 
    50                  55                  60                  


Asn Leu Tyr His Ser Ser Asp Ala Phe Lys Gln Asp Glu Ser Val Asp 
65                  70                  75                  80  


Tyr Gly Pro Val Phe Val Gln Glu Pro Asp Asp Ile Ile Phe Pro Thr 
                85                  90                  95      


Asp Ser Asp Glu Lys Lys Val Ala Leu Asn Cys Glu Val Arg Gly Asn 
            100                 105                 110         


Pro Val Pro Ser Tyr Arg Trp Leu Arg Asn Gly Thr Glu Ile Asp Leu 
        115                 120                 125             


Glu Ser Asp Tyr Arg Tyr Ser Leu Ile Asp Gly Thr Phe Ile Ile Ser 
    130                 135                 140                 


Asn Pro Ser Glu Ala Lys Asp Ser Gly His Tyr Gln Cys Leu Ala Thr 
145                 150                 155                 160 


Asn Thr Val Gly Ser Ile Leu Ser Arg Glu Ala Thr Leu Gln Phe Ala 
                165                 170                 175     


Tyr Leu Gly Asn Phe Ser Gly Arg Thr Arg Ser Ala Val Ser Val Arg 
            180                 185                 190         


Glu Gly Gln Gly Val Val Leu Met Cys Ser Pro Pro Pro His Ser Pro 
        195                 200                 205             


Glu Ile Ile Tyr Ser Trp Val Phe Asn Glu Phe Pro Ser Phe Val Ala 
    210                 215                 220                 


Glu Asp Ser Arg Arg Phe Ile Ser Gln Glu Thr Gly Asn Leu Tyr Ile 
225                 230                 235                 240 


Ser Lys Val Gln Thr Ser Asp Val Gly Ser Tyr Ile Cys Leu Val Lys 
                245                 250                 255     


Asn Thr Val Thr Asn Ala Arg Val Leu Ser Pro Pro Thr Pro Leu Thr 
            260                 265                 270         


Leu Arg Asn Asp Gly Val Met Gly Glu Tyr Glu Pro Lys Ile Glu Val 
        275                 280                 285             


His Phe Pro Phe Thr Val Thr Ala Ala Lys Gly Thr Thr Val Lys Met 
    290                 295                 300                 


Glu Cys Phe Ala Leu Gly Asn Pro Val Pro Thr Ile Thr Trp Met Lys 
305                 310                 315                 320 


Val Asn Gly Tyr Ile Pro Ser Lys Ala Arg Leu Arg Lys Ser Gln Ala 
                325                 330                 335     


Val Leu Glu Ile Pro Asn Val Gln Leu Asp Asp Ala Gly Ile Tyr Glu 
            340                 345                 350         


Cys Arg Ala Glu Asn Ser Arg Gly Lys Asn Ser Phe Arg Gly Gln Leu 
        355                 360                 365             


Gln Val Tyr Thr Tyr Pro His Trp Val Glu Lys Leu Asn Asp Thr Gln 
    370                 375                 380                 


Leu Asp Ser Gly Ser Pro Leu Arg Trp Glu Cys Lys Ala Thr Gly Lys 
385                 390                 395                 400 


Pro Arg Pro Thr Tyr Arg Trp Leu Lys Asn Gly Val Pro Leu Ser Pro 
                405                 410                 415     


Gln Ser Arg Val Glu Met Val Asn Gly Val Leu Met Ile His Asn Val 
            420                 425                 430         


Asn Gln Ser Asp Ala Gly Met Tyr Gln Cys Leu Ala Glu Asn Lys Tyr 
        435                 440                 445             


Gly Ala Ile Tyr Ala Ser Ala Glu Leu Lys Ile Leu Ala Ser Ala Pro 
    450                 455                 460                 


Thr Phe Ala Leu Asn Gln Leu Lys Lys Thr Ile Ile Val Thr Lys Asp 
465                 470                 475                 480 


Gln Glu Val Val Ile Glu Cys Lys Pro Gln Gly Ser Pro Lys Pro Thr 
                485                 490                 495     


Ile Ser Trp Lys Lys Gly Asp Arg Ala Val Arg Glu Asn Lys Arg Ile 
            500                 505                 510         


Ala Ile Leu Pro Asp Gly Ser Leu Arg Ile Leu Asn Ala Ser Lys Ser 
        515                 520                 525             


Asp Glu Gly Lys Tyr Val Cys Arg Gly Glu Asn Val Phe Gly Ser Ala 
    530                 535                 540                 


Glu Ile Ile Ala Ser Leu Ser Val Lys Glu Pro Thr Arg Ile Glu Leu 
545                 550                 555                 560 


Thr Pro Lys Arg Thr Glu Leu Thr Val Gly Glu Ser Ile Val Leu Asn 
                565                 570                 575     


Cys Lys Ala Ile His Asp Ala Ser Leu Asp Val Thr Phe Tyr Trp Thr 
            580                 585                 590         


Leu Lys Gly Gln Pro Ile Asp Phe Glu Glu Glu Gly Gly His Phe Glu 
        595                 600                 605             


Ser Ile Arg Ala Gln Ala Ser Ser Ala Asp Leu Met Ile Arg Asn Ile 
    610                 615                 620                 


Leu Leu Met His Ala Gly Arg Tyr Gly Cys Arg Val Gln Thr Thr Ala 
625                 630                 635                 640 


Asp Ser Val Ser Asp Glu Ala Glu Leu Leu Val Arg Gly Pro Pro Gly 
                645                 650                 655     


Pro Pro Gly Ile Val Ile Val Glu Glu Ile Thr Glu Ser Thr Ala Thr 
            660                 665                 670         


Leu Ser Trp Ser Pro Ala Ala Asp Asn His Ser Pro Ile Ser Ser Tyr 
        675                 680                 685             


Asn Leu Gln Ala Arg Ser Pro Phe Ser Leu Gly Trp Gln Thr Val Lys 
    690                 695                 700                 


Thr Val Pro Glu Ile Ile Thr Gly Asp Met Glu Ser Ala Met Ala Val 
705                 710                 715                 720 


Asp Leu Asn Pro Trp Val Glu Tyr Glu Phe Arg Val Val Ala Thr Asn 
                725                 730                 735     


Pro Ile Gly Thr Gly Asp Pro Ser Thr Pro Ser Arg Met Ile Arg Thr 
            740                 745                 750         


Asn Glu Ala Val Pro Lys Thr Ala Pro Thr Asn Val Ser Gly Arg Ser 
        755                 760                 765             


Gly Arg Arg His Glu Leu Val Ile Ala Trp Glu Pro Val Ser Glu Glu 
    770                 775                 780                 


Phe Gln Asn Gly Glu Gly Phe Gly Tyr Ile Val Ala Phe Arg Pro Asn 
785                 790                 795                 800 


Gly Thr Arg Gly Trp Lys Glu Lys Met Val Thr Ser Ser Glu Ala Ser 
                805                 810                 815     


Lys Phe Ile Tyr Arg Asp Glu Ser Val Pro Pro Leu Thr Pro Phe Glu 
            820                 825                 830         


Val Lys Val Gly Val Tyr Asn Asn Lys Gly Asp Gly Pro Phe Ser Gln 
        835                 840                 845             


Ile Val Val Ile Cys Ser Ala Glu Gly Glu Pro Ser Ala Ala Pro Thr 
    850                 855                 860                 


Asp Val Lys Ala Thr Ser Val Ser Val Ser Glu Ile Leu Val Ala Trp 
865                 870                 875                 880 


Lys His Ile Lys Glu Ser Leu Gly Arg Pro Gln Gly Phe Glu Val Gly 
                885                 890                 895     


Tyr Trp Lys Asp Met Glu Gln Glu Asp Thr Ala Glu Thr Val Lys Thr 
            900                 905                 910         


Arg Gly Asn Glu Ser Phe Val Ile Leu Thr Gly Leu Glu Gly Asn Thr 
        915                 920                 925             


Leu Tyr His Phe Thr Val Arg Ala Tyr Asn Gly Ala Gly Tyr Gly Pro 
    930                 935                 940                 


Pro Ser Ser Glu Val Ser Ala Thr Thr Lys Lys Ser Pro Pro Ser Gln 
945                 950                 955                 960 


Ala Pro Ser Asn Leu Arg Trp Glu Gln Gln Gly Ser Gln Val Ser Leu 
                965                 970                 975     


Gly Trp Glu Pro Val Ile Pro Leu Ala Asn Glu Ser Glu Val Val Gly 
            980                 985                 990         


Tyr Lys Val Phe Tyr Arg Gln Glu  Gly His Ser Asn Ser  Gln Val Ile 
        995                 1000                 1005             


Glu Thr  Gln Lys Leu Gln Ala  Val Val Pro Leu Pro  Asp Ala Gly 
    1010                 1015                 1020             


Val Tyr  Ile Ile Glu Val Arg  Ala Tyr Ser Glu Gly  Gly Asp Gly 
    1025                 1030                 1035             


Thr Ala  Ser Ser Gln Ile Arg  Val Pro Ser Tyr Ser  Gly Gly Lys 
    1040                 1045                 1050             


Ile Thr  Ser Ala Gln Ser Thr  Leu His Ser Leu Ser  Thr Ser Ser 
    1055                 1060                 1065             


Ser Ser  Val Thr Leu Leu Leu  Ala Leu Met Ile Pro  Ser Thr Ser 
    1070                 1075                 1080             


Trp 
    


<210>  3155
<211>  1026
<212>  PRT
<213>  Homo Sapiens

<400>  3155

Met Ala Ser Ser Trp Lys Leu Met Leu Phe Leu Ser Val Thr Met Cys 
1               5                   10                  15      


Leu Ser Glu Ser Val Asp Tyr Gly Pro Val Phe Val Gln Glu Pro Asp 
            20                  25                  30          


Asp Ile Ile Phe Pro Thr Asp Ser Asp Glu Lys Lys Val Ala Leu Asn 
        35                  40                  45              


Cys Glu Val Arg Gly Asn Pro Val Pro Ser Tyr Arg Trp Leu Arg Asn 
    50                  55                  60                  


Gly Thr Glu Ile Asp Leu Glu Ser Asp Tyr Arg Tyr Ser Leu Ile Asp 
65                  70                  75                  80  


Gly Thr Phe Ile Ile Ser Asn Pro Ser Glu Ala Lys Asp Ser Gly His 
                85                  90                  95      


Tyr Gln Cys Leu Ala Thr Asn Thr Val Gly Ser Ile Leu Ser Arg Glu 
            100                 105                 110         


Ala Thr Leu Gln Phe Ala Tyr Leu Gly Asn Phe Ser Gly Arg Thr Arg 
        115                 120                 125             


Ser Ala Val Ser Val Arg Glu Gly Gln Gly Val Val Leu Met Cys Ser 
    130                 135                 140                 


Pro Pro Pro His Ser Pro Glu Ile Ile Tyr Ser Trp Val Phe Asn Glu 
145                 150                 155                 160 


Phe Pro Ser Phe Val Ala Glu Asp Ser Arg Arg Phe Ile Ser Gln Glu 
                165                 170                 175     


Thr Gly Asn Leu Tyr Ile Ser Lys Val Gln Thr Ser Asp Val Gly Ser 
            180                 185                 190         


Tyr Ile Cys Leu Val Lys Asn Thr Val Thr Asn Ala Arg Val Leu Ser 
        195                 200                 205             


Pro Pro Thr Pro Leu Thr Leu Arg Asn Asp Gly Val Met Gly Glu Tyr 
    210                 215                 220                 


Glu Pro Lys Ile Glu Val His Phe Pro Phe Thr Val Thr Ala Ala Lys 
225                 230                 235                 240 


Gly Thr Thr Val Lys Met Glu Cys Phe Ala Leu Gly Asn Pro Val Pro 
                245                 250                 255     


Thr Ile Thr Trp Met Lys Val Asn Gly Tyr Ile Pro Ser Lys Ala Arg 
            260                 265                 270         


Leu Arg Lys Ser Gln Ala Val Leu Glu Ile Pro Asn Val Gln Leu Asp 
        275                 280                 285             


Asp Ala Gly Ile Tyr Glu Cys Arg Ala Glu Asn Ser Arg Gly Lys Asn 
    290                 295                 300                 


Ser Phe Arg Gly Gln Leu Gln Val Tyr Thr Tyr Pro His Trp Val Glu 
305                 310                 315                 320 


Lys Leu Asn Asp Thr Gln Leu Asp Ser Gly Ser Pro Leu Arg Trp Glu 
                325                 330                 335     


Cys Lys Ala Thr Gly Lys Pro Arg Pro Thr Tyr Arg Trp Leu Lys Asn 
            340                 345                 350         


Gly Val Pro Leu Ser Pro Gln Ser Arg Val Glu Met Val Asn Gly Val 
        355                 360                 365             


Leu Met Ile His Asn Val Asn Gln Ser Asp Ala Gly Met Tyr Gln Cys 
    370                 375                 380                 


Leu Ala Glu Asn Lys Tyr Gly Ala Ile Tyr Ala Ser Ala Glu Leu Lys 
385                 390                 395                 400 


Ile Leu Ala Ser Ala Pro Thr Phe Ala Leu Asn Gln Leu Lys Lys Thr 
                405                 410                 415     


Ile Ile Val Thr Lys Asp Gln Glu Val Val Ile Glu Cys Lys Pro Gln 
            420                 425                 430         


Gly Ser Pro Lys Pro Thr Ile Ser Trp Lys Lys Gly Asp Arg Ala Val 
        435                 440                 445             


Arg Glu Asn Lys Arg Ile Ala Ile Leu Pro Asp Gly Ser Leu Arg Ile 
    450                 455                 460                 


Leu Asn Ala Ser Lys Ser Asp Glu Gly Lys Tyr Val Cys Arg Gly Glu 
465                 470                 475                 480 


Asn Val Phe Gly Ser Ala Glu Ile Ile Ala Ser Leu Ser Val Lys Glu 
                485                 490                 495     


Pro Thr Arg Ile Glu Leu Thr Pro Lys Arg Thr Glu Leu Thr Val Gly 
            500                 505                 510         


Glu Ser Ile Val Leu Asn Cys Lys Ala Ile His Asp Ala Ser Leu Asp 
        515                 520                 525             


Val Thr Phe Tyr Trp Thr Leu Lys Gly Gln Pro Ile Asp Phe Glu Glu 
    530                 535                 540                 


Glu Gly Gly His Phe Glu Ser Ile Arg Ala Gln Ala Ser Ser Ala Asp 
545                 550                 555                 560 


Leu Met Ile Arg Asn Ile Leu Leu Met His Ala Gly Arg Tyr Gly Cys 
                565                 570                 575     


Arg Val Gln Thr Thr Ala Asp Ser Val Ser Asp Glu Ala Glu Leu Leu 
            580                 585                 590         


Val Arg Gly Pro Pro Gly Pro Pro Gly Ile Val Ile Val Glu Glu Ile 
        595                 600                 605             


Thr Glu Ser Thr Ala Thr Leu Ser Trp Ser Pro Ala Ala Asp Asn His 
    610                 615                 620                 


Ser Pro Ile Ser Ser Tyr Asn Leu Gln Ala Arg Ser Pro Phe Ser Leu 
625                 630                 635                 640 


Gly Trp Gln Thr Val Lys Thr Val Pro Glu Ile Ile Thr Gly Asp Met 
                645                 650                 655     


Glu Ser Ala Met Ala Val Asp Leu Asn Pro Trp Val Glu Tyr Glu Phe 
            660                 665                 670         


Arg Val Val Ala Thr Asn Pro Ile Gly Thr Gly Asp Pro Ser Thr Pro 
        675                 680                 685             


Ser Arg Met Ile Arg Thr Asn Glu Ala Val Pro Lys Thr Ala Pro Thr 
    690                 695                 700                 


Asn Val Ser Gly Arg Ser Gly Arg Arg His Glu Leu Val Ile Ala Trp 
705                 710                 715                 720 


Glu Pro Val Ser Glu Glu Phe Gln Asn Gly Glu Gly Phe Gly Tyr Ile 
                725                 730                 735     


Val Ala Phe Arg Pro Asn Gly Thr Arg Gly Trp Lys Glu Lys Met Val 
            740                 745                 750         


Thr Ser Ser Glu Ala Ser Lys Phe Ile Tyr Arg Asp Glu Ser Val Pro 
        755                 760                 765             


Pro Leu Thr Pro Phe Glu Val Lys Val Gly Val Tyr Asn Asn Lys Gly 
    770                 775                 780                 


Asp Gly Pro Phe Ser Gln Ile Val Val Ile Cys Ser Ala Glu Gly Glu 
785                 790                 795                 800 


Pro Ser Ala Ala Pro Thr Asp Val Lys Ala Thr Ser Val Ser Val Ser 
                805                 810                 815     


Glu Ile Leu Val Ala Trp Lys His Ile Lys Glu Ser Leu Gly Arg Pro 
            820                 825                 830         


Gln Gly Phe Glu Val Gly Tyr Trp Lys Asp Met Glu Gln Glu Asp Thr 
        835                 840                 845             


Ala Glu Thr Val Lys Thr Arg Gly Asn Glu Ser Phe Val Ile Leu Thr 
    850                 855                 860                 


Gly Leu Glu Gly Asn Thr Leu Tyr His Phe Thr Val Arg Ala Tyr Asn 
865                 870                 875                 880 


Gly Ala Gly Tyr Gly Pro Pro Ser Ser Glu Val Ser Ala Thr Thr Lys 
                885                 890                 895     


Lys Ser Pro Pro Ser Gln Ala Pro Ser Asn Leu Arg Trp Glu Gln Gln 
            900                 905                 910         


Gly Ser Gln Val Ser Leu Gly Trp Glu Pro Val Ile Pro Leu Ala Asn 
        915                 920                 925             


Glu Ser Glu Val Val Gly Tyr Lys Val Phe Tyr Arg Gln Glu Gly His 
    930                 935                 940                 


Ser Asn Ser Gln Val Ile Glu Thr Gln Lys Leu Gln Ala Val Val Pro 
945                 950                 955                 960 


Leu Pro Asp Ala Gly Val Tyr Ile Ile Glu Val Arg Ala Tyr Ser Glu 
                965                 970                 975     


Gly Gly Asp Gly Thr Ala Ser Ser Gln Ile Arg Val Pro Ser Tyr Ser 
            980                 985                 990         


Gly Gly Lys Ile Thr Ser Ala Gln  Ser Thr Leu His Ser  Leu Ser Thr 
        995                 1000                 1005             


Ser Ser  Ser Ser Val Thr Leu  Leu Leu Ala Leu Met  Ile Pro Ser 
    1010                 1015                 1020             


Thr Ser  Trp 
    1025     


<210>  3156
<211>  1100
<212>  PRT
<213>  Homo Sapiens

<400>  3156

Met Ala Ser Ser Trp Lys Leu Met Leu Phe Leu Ser Val Thr Met Cys 
1               5                   10                  15      


Leu Ser Glu Tyr Ser Lys Ser Leu Pro Gly Leu Ser Thr Ser Tyr Ala 
            20                  25                  30          


Ala Leu Leu Arg Ile Lys Lys Ser Ser Ser Ser Ser Leu Phe Gly Ser 
        35                  40                  45              


Lys Thr Arg Pro Arg Tyr Ser Ser Pro Ser Leu Gly Thr Leu Ser Ala 
    50                  55                  60                  


Ser Ser Pro Ser Trp Leu Gly Ala Ala Gln Asn Tyr Tyr Ser Pro Ile 
65                  70                  75                  80  


Asn Leu Tyr His Ser Ser Asp Ala Phe Lys Gln Asp Glu Ser Val Asp 
                85                  90                  95      


Tyr Gly Pro Val Phe Val Gln Glu Pro Asp Asp Ile Ile Phe Pro Thr 
            100                 105                 110         


Asp Ser Asp Glu Lys Lys Val Ala Leu Asn Cys Glu Val Arg Gly Asn 
        115                 120                 125             


Pro Val Pro Ser Tyr Arg Trp Leu Arg Asn Gly Thr Glu Ile Asp Leu 
    130                 135                 140                 


Glu Ser Asp Tyr Arg Tyr Ser Leu Ile Asp Gly Thr Phe Ile Ile Ser 
145                 150                 155                 160 


Asn Pro Ser Glu Ala Lys Asp Ser Gly His Tyr Gln Cys Leu Ala Thr 
                165                 170                 175     


Asn Thr Val Gly Ser Ile Leu Ser Arg Glu Ala Thr Leu Gln Phe Ala 
            180                 185                 190         


Tyr Leu Gly Asn Phe Ser Gly Arg Thr Arg Ser Ala Val Ser Val Arg 
        195                 200                 205             


Glu Gly Gln Gly Val Val Leu Met Cys Ser Pro Pro Pro His Ser Pro 
    210                 215                 220                 


Glu Ile Ile Tyr Ser Trp Val Phe Asn Glu Phe Pro Ser Phe Val Ala 
225                 230                 235                 240 


Glu Asp Ser Arg Arg Phe Ile Ser Gln Glu Thr Gly Asn Leu Tyr Ile 
                245                 250                 255     


Ser Lys Val Gln Thr Ser Asp Val Gly Ser Tyr Ile Cys Leu Val Lys 
            260                 265                 270         


Asn Thr Val Thr Asn Ala Arg Val Leu Ser Pro Pro Thr Pro Leu Thr 
        275                 280                 285             


Leu Arg Asn Asp Gly Val Met Gly Glu Tyr Glu Pro Lys Ile Glu Val 
    290                 295                 300                 


His Phe Pro Phe Thr Val Thr Ala Ala Lys Gly Thr Thr Val Lys Met 
305                 310                 315                 320 


Glu Cys Phe Ala Leu Gly Asn Pro Val Pro Thr Ile Thr Trp Met Lys 
                325                 330                 335     


Val Asn Gly Tyr Ile Pro Ser Lys Ala Arg Leu Arg Lys Ser Gln Ala 
            340                 345                 350         


Val Leu Glu Ile Pro Asn Val Gln Leu Asp Asp Ala Gly Ile Tyr Glu 
        355                 360                 365             


Cys Arg Ala Glu Asn Ser Arg Gly Lys Asn Ser Phe Arg Gly Gln Leu 
    370                 375                 380                 


Gln Val Tyr Thr Tyr Pro His Trp Val Glu Lys Leu Asn Asp Thr Gln 
385                 390                 395                 400 


Leu Asp Ser Gly Ser Pro Leu Arg Trp Glu Cys Lys Ala Thr Gly Lys 
                405                 410                 415     


Pro Arg Pro Thr Tyr Arg Trp Leu Lys Asn Gly Val Pro Leu Ser Pro 
            420                 425                 430         


Gln Ser Arg Val Glu Met Val Asn Gly Val Leu Met Ile His Asn Val 
        435                 440                 445             


Asn Gln Ser Asp Ala Gly Met Tyr Gln Cys Leu Ala Glu Asn Lys Tyr 
    450                 455                 460                 


Gly Ala Ile Tyr Ala Ser Ala Glu Leu Lys Ile Leu Ala Ser Ala Pro 
465                 470                 475                 480 


Thr Phe Ala Leu Asn Gln Leu Lys Lys Thr Ile Ile Val Thr Lys Asp 
                485                 490                 495     


Gln Glu Val Val Ile Glu Cys Lys Pro Gln Gly Ser Pro Lys Pro Thr 
            500                 505                 510         


Ile Ser Trp Lys Lys Gly Asp Arg Ala Val Arg Glu Asn Lys Arg Ile 
        515                 520                 525             


Ala Ile Leu Pro Asp Gly Ser Leu Arg Ile Leu Asn Ala Ser Lys Ser 
    530                 535                 540                 


Asp Glu Gly Lys Tyr Val Cys Arg Gly Glu Asn Val Phe Gly Ser Ala 
545                 550                 555                 560 


Glu Ile Ile Ala Ser Leu Ser Val Lys Glu Pro Thr Arg Ile Glu Leu 
                565                 570                 575     


Thr Pro Lys Arg Thr Glu Leu Thr Val Gly Glu Ser Ile Val Leu Asn 
            580                 585                 590         


Cys Lys Ala Ile His Asp Ala Ser Leu Asp Val Thr Phe Tyr Trp Thr 
        595                 600                 605             


Leu Lys Gly Gln Pro Ile Asp Phe Glu Glu Glu Gly Gly His Phe Glu 
    610                 615                 620                 


Ser Ile Arg Ala Gln Ala Ser Ser Ala Asp Leu Met Ile Arg Asn Ile 
625                 630                 635                 640 


Leu Leu Met His Ala Gly Arg Tyr Gly Cys Arg Val Gln Thr Thr Ala 
                645                 650                 655     


Asp Ser Val Ser Asp Glu Ala Glu Leu Leu Val Arg Gly Pro Pro Gly 
            660                 665                 670         


Pro Pro Gly Ile Val Ile Val Glu Glu Ile Thr Glu Ser Thr Ala Thr 
        675                 680                 685             


Leu Ser Trp Ser Pro Ala Ala Asp Asn His Ser Pro Ile Ser Ser Tyr 
    690                 695                 700                 


Asn Leu Gln Ala Arg Ser Pro Phe Ser Leu Gly Trp Gln Thr Val Lys 
705                 710                 715                 720 


Thr Val Pro Glu Ile Ile Thr Gly Asp Met Glu Ser Ala Met Ala Val 
                725                 730                 735     


Asp Leu Asn Pro Trp Val Glu Tyr Glu Phe Arg Val Val Ala Thr Asn 
            740                 745                 750         


Pro Ile Gly Thr Gly Asp Pro Ser Thr Pro Ser Arg Met Ile Arg Thr 
        755                 760                 765             


Asn Glu Ala Val Pro Lys Thr Ala Pro Thr Asn Val Ser Gly Arg Ser 
    770                 775                 780                 


Gly Arg Arg His Glu Leu Val Ile Ala Trp Glu Pro Val Ser Glu Glu 
785                 790                 795                 800 


Phe Gln Asn Gly Glu Gly Phe Gly Tyr Ile Val Ala Phe Arg Pro Asn 
                805                 810                 815     


Gly Thr Arg Gly Trp Lys Glu Lys Met Val Thr Ser Ser Glu Ala Ser 
            820                 825                 830         


Lys Phe Ile Tyr Arg Asp Glu Ser Val Pro Pro Leu Thr Pro Phe Glu 
        835                 840                 845             


Val Lys Val Gly Val Tyr Asn Asn Lys Gly Asp Gly Pro Phe Ser Gln 
    850                 855                 860                 


Ile Val Val Ile Cys Ser Ala Glu Gly Glu Pro Ser Ala Ala Pro Thr 
865                 870                 875                 880 


Asp Val Lys Ala Thr Ser Val Ser Val Ser Glu Ile Leu Val Ala Trp 
                885                 890                 895     


Lys His Ile Lys Glu Ser Leu Gly Arg Pro Gln Gly Phe Glu Val Gly 
            900                 905                 910         


Tyr Trp Lys Asp Met Glu Gln Glu Asp Thr Ala Glu Thr Val Lys Thr 
        915                 920                 925             


Arg Gly Asn Glu Ser Phe Val Ile Leu Thr Gly Leu Glu Gly Asn Thr 
    930                 935                 940                 


Leu Tyr His Phe Thr Val Arg Ala Tyr Asn Gly Ala Gly Tyr Gly Pro 
945                 950                 955                 960 


Pro Ser Ser Glu Val Ser Ala Thr Thr Lys Lys Ser Pro Pro Ser Gln 
                965                 970                 975     


Ala Pro Ser Asn Leu Arg Trp Glu Gln Gln Gly Ser Gln Val Ser Leu 
            980                 985                 990         


Gly Trp Glu Pro Val Ile Pro Leu  Ala Asn Glu Ser Glu  Val Val Gly 
        995                 1000                 1005             


Tyr Lys  Val Phe Tyr Arg Gln  Glu Gly His Ser Asn  Ser Gln Val 
    1010                 1015                 1020             


Ile Glu  Thr Gln Lys Leu Gln  Ala Val Val Pro Leu  Pro Asp Ala 
    1025                 1030                 1035             


Gly Val  Tyr Ile Ile Glu Val  Arg Ala Tyr Ser Glu  Gly Gly Asp 
    1040                 1045                 1050             


Gly Thr  Ala Ser Ser Gln Ile  Arg Val Pro Ser Tyr  Ser Gly Gly 
    1055                 1060                 1065             


Lys Ile  Thr Ser Ala Gln Ser  Thr Leu His Ser Leu  Ser Thr Ser 
    1070                 1075                 1080             


Ser Ser  Ser Val Thr Leu Leu  Leu Ala Leu Met Ile  Pro Ser Thr 
    1085                 1090                 1095             


Ser Trp  
    1100 


<210>  3157
<211>  1100
<212>  PRT
<213>  Homo Sapiens

<400>  3157

Met Ala Ser Ser Trp Lys Leu Met Leu Phe Leu Ser Val Thr Met Cys 
1               5                   10                  15      


Leu Ser Glu Tyr Ser Lys Ser Leu Pro Gly Leu Ser Thr Ser Tyr Ala 
            20                  25                  30          


Ala Leu Leu Arg Ile Lys Lys Ser Ser Ser Ser Ser Leu Phe Gly Ser 
        35                  40                  45              


Lys Thr Arg Pro Arg Tyr Ser Ser Pro Ser Leu Gly Thr Leu Ser Ala 
    50                  55                  60                  


Ser Ser Pro Ser Trp Leu Gly Ala Ala Gln Asn Tyr Tyr Ser Pro Ile 
65                  70                  75                  80  


Asn Leu Tyr His Ser Ser Asp Ala Phe Lys Gln Asp Glu Ser Val Asp 
                85                  90                  95      


Tyr Gly Pro Val Phe Val Gln Glu Pro Asp Asp Ile Ile Phe Pro Thr 
            100                 105                 110         


Asp Ser Asp Glu Lys Lys Val Ala Leu Asn Cys Glu Val Arg Gly Asn 
        115                 120                 125             


Pro Val Pro Ser Tyr Arg Trp Leu Arg Asn Gly Thr Glu Ile Asp Leu 
    130                 135                 140                 


Glu Ser Asp Tyr Arg Tyr Ser Leu Ile Asp Gly Thr Phe Ile Ile Ser 
145                 150                 155                 160 


Asn Pro Ser Glu Ala Lys Asp Ser Gly His Tyr Gln Cys Leu Ala Thr 
                165                 170                 175     


Asn Thr Val Gly Ser Ile Leu Ser Arg Glu Ala Thr Leu Gln Phe Ala 
            180                 185                 190         


Tyr Leu Gly Asn Phe Ser Gly Arg Thr Arg Ser Ala Val Ser Val Arg 
        195                 200                 205             


Glu Gly Gln Gly Val Val Leu Met Cys Ser Pro Pro Pro His Ser Pro 
    210                 215                 220                 


Glu Ile Ile Tyr Ser Trp Val Phe Asn Glu Phe Pro Ser Phe Val Ala 
225                 230                 235                 240 


Glu Asp Ser Arg Arg Phe Ile Ser Gln Glu Thr Gly Asn Leu Tyr Ile 
                245                 250                 255     


Ser Lys Val Gln Thr Ser Asp Val Gly Ser Tyr Ile Cys Leu Val Lys 
            260                 265                 270         


Asn Thr Val Thr Asn Ala Arg Val Leu Ser Pro Pro Thr Pro Leu Thr 
        275                 280                 285             


Leu Arg Asn Asp Gly Val Met Gly Glu Tyr Glu Pro Lys Ile Glu Val 
    290                 295                 300                 


His Phe Pro Phe Thr Val Thr Ala Ala Lys Gly Thr Thr Val Lys Met 
305                 310                 315                 320 


Glu Cys Phe Ala Leu Gly Asn Pro Val Pro Thr Ile Thr Trp Met Lys 
                325                 330                 335     


Val Asn Gly Tyr Ile Pro Ser Lys Ala Arg Leu Arg Lys Ser Gln Ala 
            340                 345                 350         


Val Leu Glu Ile Pro Asn Val Gln Leu Asp Asp Ala Gly Ile Tyr Glu 
        355                 360                 365             


Cys Arg Ala Glu Asn Ser Arg Gly Lys Asn Ser Phe Arg Gly Gln Leu 
    370                 375                 380                 


Gln Val Tyr Thr Tyr Pro His Trp Val Glu Lys Leu Asn Asp Thr Gln 
385                 390                 395                 400 


Leu Asp Ser Gly Ser Pro Leu Arg Trp Glu Cys Lys Ala Thr Gly Lys 
                405                 410                 415     


Pro Arg Pro Thr Tyr Arg Trp Leu Lys Asn Gly Val Pro Leu Ser Pro 
            420                 425                 430         


Gln Ser Arg Val Glu Met Val Asn Gly Val Leu Met Ile His Asn Val 
        435                 440                 445             


Asn Gln Ser Asp Ala Gly Met Tyr Gln Cys Leu Ala Glu Asn Lys Tyr 
    450                 455                 460                 


Gly Ala Ile Tyr Ala Ser Ala Glu Leu Lys Ile Leu Ala Ser Ala Pro 
465                 470                 475                 480 


Thr Phe Ala Leu Asn Gln Leu Lys Lys Thr Ile Ile Val Thr Lys Asp 
                485                 490                 495     


Gln Glu Val Val Ile Glu Cys Lys Pro Gln Gly Ser Pro Lys Pro Thr 
            500                 505                 510         


Ile Ser Trp Lys Lys Gly Asp Arg Ala Val Arg Glu Asn Lys Arg Ile 
        515                 520                 525             


Ala Ile Leu Pro Asp Gly Ser Leu Arg Ile Leu Asn Ala Ser Lys Ser 
    530                 535                 540                 


Asp Glu Gly Lys Tyr Val Cys Arg Gly Glu Asn Val Phe Gly Ser Ala 
545                 550                 555                 560 


Glu Ile Ile Ala Ser Leu Ser Val Lys Glu Pro Thr Arg Ile Glu Leu 
                565                 570                 575     


Thr Pro Lys Arg Thr Glu Leu Thr Val Gly Glu Ser Ile Val Leu Asn 
            580                 585                 590         


Cys Lys Ala Ile His Asp Ala Ser Leu Asp Val Thr Phe Tyr Trp Thr 
        595                 600                 605             


Leu Lys Gly Gln Pro Ile Asp Phe Glu Glu Glu Gly Gly His Phe Glu 
    610                 615                 620                 


Ser Ile Arg Ala Gln Ala Ser Ser Ala Asp Leu Met Ile Arg Asn Ile 
625                 630                 635                 640 


Leu Leu Met His Ala Gly Arg Tyr Gly Cys Arg Val Gln Thr Thr Ala 
                645                 650                 655     


Asp Ser Val Ser Asp Glu Ala Glu Leu Leu Val Arg Gly Pro Pro Gly 
            660                 665                 670         


Pro Pro Gly Ile Val Ile Val Glu Glu Ile Thr Glu Ser Thr Ala Thr 
        675                 680                 685             


Leu Ser Trp Ser Pro Ala Ala Asp Asn His Ser Pro Ile Ser Ser Tyr 
    690                 695                 700                 


Asn Leu Gln Ala Arg Ser Pro Phe Ser Leu Gly Trp Gln Thr Val Lys 
705                 710                 715                 720 


Thr Val Pro Glu Ile Ile Thr Gly Asp Met Glu Ser Ala Met Ala Val 
                725                 730                 735     


Asp Leu Asn Pro Trp Val Glu Tyr Glu Phe Arg Val Val Ala Thr Asn 
            740                 745                 750         


Pro Ile Gly Thr Gly Asp Pro Ser Thr Pro Ser Arg Met Ile Arg Thr 
        755                 760                 765             


Asn Glu Ala Val Pro Lys Thr Ala Pro Thr Asn Val Ser Gly Arg Ser 
    770                 775                 780                 


Gly Arg Arg His Glu Leu Val Ile Ala Trp Glu Pro Val Ser Glu Glu 
785                 790                 795                 800 


Phe Gln Asn Gly Glu Gly Phe Gly Tyr Ile Val Ala Phe Arg Pro Asn 
                805                 810                 815     


Gly Thr Arg Gly Trp Lys Glu Lys Met Val Thr Ser Ser Glu Ala Ser 
            820                 825                 830         


Lys Phe Ile Tyr Arg Asp Glu Ser Val Pro Pro Leu Thr Pro Phe Glu 
        835                 840                 845             


Val Lys Val Gly Val Tyr Asn Asn Lys Gly Asp Gly Pro Phe Ser Gln 
    850                 855                 860                 


Ile Val Val Ile Cys Ser Ala Glu Gly Glu Pro Ser Ala Ala Pro Thr 
865                 870                 875                 880 


Asp Val Lys Ala Thr Ser Val Ser Val Ser Glu Ile Leu Val Ala Trp 
                885                 890                 895     


Lys His Ile Lys Glu Ser Leu Gly Arg Pro Gln Gly Phe Glu Val Gly 
            900                 905                 910         


Tyr Trp Lys Asp Met Glu Gln Glu Asp Thr Ala Glu Thr Val Lys Thr 
        915                 920                 925             


Arg Gly Asn Glu Ser Phe Val Ile Leu Thr Gly Leu Glu Gly Asn Thr 
    930                 935                 940                 


Leu Tyr His Phe Thr Val Arg Ala Tyr Asn Gly Ala Gly Tyr Gly Pro 
945                 950                 955                 960 


Pro Ser Ser Glu Val Ser Ala Thr Thr Lys Lys Ser Pro Pro Ser Gln 
                965                 970                 975     


Ala Pro Ser Asn Leu Arg Trp Glu Gln Gln Gly Ser Gln Val Ser Leu 
            980                 985                 990         


Gly Trp Glu Pro Val Ile Pro Leu  Ala Asn Glu Ser Glu  Val Val Gly 
        995                 1000                 1005             


Tyr Lys  Val Phe Tyr Arg Gln  Glu Gly His Ser Asn  Ser Gln Val 
    1010                 1015                 1020             


Ile Glu  Thr Gln Lys Leu Gln  Ala Val Val Pro Leu  Pro Asp Ala 
    1025                 1030                 1035             


Gly Val  Tyr Ile Ile Glu Val  Arg Ala Tyr Ser Glu  Gly Gly Asp 
    1040                 1045                 1050             


Gly Thr  Ala Ser Ser Gln Ile  Arg Val Pro Ser Tyr  Ser Gly Gly 
    1055                 1060                 1065             


Lys Ile  Thr Ser Ala Gln Ser  Thr Leu His Ser Leu  Ser Thr Ser 
    1070                 1075                 1080             


Ser Ser  Ser Val Thr Leu Leu  Leu Ala Leu Met Ile  Pro Ser Thr 
    1085                 1090                 1095             


Ser Trp  
    1100 


<210>  3158
<211>  911
<212>  PRT
<213>  Homo Sapiens

<400>  3158

Met Ala Ser Ser Trp Lys Leu Met Leu Phe Leu Ser Val Thr Met Cys 
1               5                   10                  15      


Leu Ser Glu Tyr Ser Lys Ser Leu Pro Gly Leu Ser Thr Ser Tyr Ala 
            20                  25                  30          


Ala Leu Leu Arg Ile Lys Lys Ser Ser Ser Ser Ser Leu Phe Gly Ser 
        35                  40                  45              


Lys Thr Arg Pro Arg Tyr Ser Ser Pro Ser Leu Gly Thr Leu Ser Ala 
    50                  55                  60                  


Ser Ser Pro Ser Trp Leu Gly Ala Ala Gln Asn Tyr Tyr Ser Pro Ile 
65                  70                  75                  80  


Asn Leu Tyr His Ser Ser Asp Ala Phe Lys Gln Asp Glu Ser Val Asp 
                85                  90                  95      


Tyr Gly Pro Val Phe Val Gln Glu Pro Asp Asp Ile Ile Phe Pro Thr 
            100                 105                 110         


Asp Ser Asp Glu Lys Lys Val Ala Leu Asn Cys Glu Val Arg Gly Asn 
        115                 120                 125             


Pro Val Pro Ser Tyr Arg Trp Leu Arg Asn Gly Thr Glu Ile Asp Leu 
    130                 135                 140                 


Glu Ser Asp Tyr Arg Tyr Ser Leu Ile Asp Gly Thr Phe Ile Ile Ser 
145                 150                 155                 160 


Asn Pro Ser Glu Ala Lys Asp Ser Gly His Tyr Gln Cys Leu Ala Thr 
                165                 170                 175     


Asn Thr Val Gly Ser Ile Leu Ser Arg Glu Ala Thr Leu Gln Phe Ala 
            180                 185                 190         


Tyr Leu Gly Asn Phe Ser Gly Arg Thr Arg Ser Ala Val Ser Val Arg 
        195                 200                 205             


Glu Gly Gln Gly Val Val Leu Met Cys Ser Pro Pro Pro His Ser Pro 
    210                 215                 220                 


Glu Ile Ile Tyr Ser Trp Val Phe Asn Glu Phe Pro Ser Phe Val Ala 
225                 230                 235                 240 


Glu Asp Ser Arg Arg Phe Ile Ser Gln Glu Thr Gly Asn Leu Tyr Ile 
                245                 250                 255     


Ser Lys Val Gln Thr Ser Asp Val Gly Ser Tyr Ile Cys Leu Val Lys 
            260                 265                 270         


Asn Thr Val Thr Asn Ala Arg Val Leu Ser Pro Pro Thr Pro Leu Thr 
        275                 280                 285             


Leu Arg Asn Asp Gly Val Met Gly Glu Tyr Glu Pro Lys Ile Glu Val 
    290                 295                 300                 


His Phe Pro Phe Thr Val Thr Ala Ala Lys Gly Thr Thr Val Lys Met 
305                 310                 315                 320 


Glu Cys Phe Ala Leu Gly Asn Pro Val Pro Thr Ile Thr Trp Met Lys 
                325                 330                 335     


Val Asn Gly Tyr Ile Pro Ser Lys Ala Arg Leu Arg Lys Ser Gln Ala 
            340                 345                 350         


Val Leu Glu Ile Pro Asn Val Gln Leu Asp Asp Ala Gly Ile Tyr Glu 
        355                 360                 365             


Cys Arg Ala Glu Asn Ser Arg Gly Lys Asn Ser Phe Arg Gly Gln Leu 
    370                 375                 380                 


Gln Val Tyr Thr Tyr Pro His Trp Val Glu Lys Leu Asn Asp Thr Gln 
385                 390                 395                 400 


Leu Asp Ser Gly Ser Pro Leu Arg Trp Glu Cys Lys Ala Thr Gly Lys 
                405                 410                 415     


Pro Arg Pro Thr Tyr Arg Trp Leu Lys Asn Gly Val Pro Leu Ser Pro 
            420                 425                 430         


Gln Ser Arg Val Glu Met Val Asn Gly Val Leu Met Ile His Asn Val 
        435                 440                 445             


Asn Gln Ser Asp Ala Gly Met Tyr Gln Cys Leu Ala Glu Asn Lys Tyr 
    450                 455                 460                 


Gly Ala Ile Tyr Ala Ser Ala Glu Leu Lys Ile Leu Ala Ser Ala Pro 
465                 470                 475                 480 


Thr Phe Ala Leu Asn Gln Leu Lys Lys Thr Ile Ile Val Thr Lys Asp 
                485                 490                 495     


Gln Glu Val Val Ile Glu Cys Lys Pro Gln Gly Ser Pro Lys Pro Thr 
            500                 505                 510         


Ile Ser Trp Lys Lys Gly Asp Arg Ala Val Arg Glu Asn Lys Arg Ile 
        515                 520                 525             


Ala Ile Leu Pro Asp Gly Ser Leu Arg Ile Leu Asn Ala Ser Lys Ser 
    530                 535                 540                 


Asp Glu Gly Lys Tyr Val Cys Arg Gly Glu Asn Val Phe Gly Ser Ala 
545                 550                 555                 560 


Glu Ile Ile Ala Ser Leu Ser Val Lys Glu Pro Thr Arg Ile Glu Leu 
                565                 570                 575     


Thr Pro Lys Arg Thr Glu Leu Thr Val Gly Glu Ser Ile Val Leu Asn 
            580                 585                 590         


Cys Lys Ala Ile His Asp Ala Ser Leu Asp Val Thr Phe Tyr Trp Thr 
        595                 600                 605             


Leu Lys Gly Gln Pro Ile Asp Phe Glu Glu Glu Gly Gly His Phe Glu 
    610                 615                 620                 


Ser Ile Arg Ala Gln Ala Ser Ser Ala Asp Leu Met Ile Arg Asn Ile 
625                 630                 635                 640 


Leu Leu Met His Ala Gly Arg Tyr Gly Cys Arg Val Gln Thr Thr Ala 
                645                 650                 655     


Asp Ser Val Ser Asp Glu Ala Glu Leu Leu Val Arg Gly Pro Pro Gly 
            660                 665                 670         


Pro Pro Gly Ile Val Ile Val Glu Glu Ile Thr Glu Ser Thr Ala Thr 
        675                 680                 685             


Leu Ser Trp Ser Pro Ala Ala Asp Asn His Ser Pro Ile Ser Ser Tyr 
    690                 695                 700                 


Asn Leu Gln Ala Arg Ser Pro Phe Ser Leu Gly Trp Gln Thr Val Lys 
705                 710                 715                 720 


Thr Val Pro Glu Ile Ile Thr Gly Asp Met Glu Ser Ala Met Ala Val 
                725                 730                 735     


Asp Leu Asn Pro Trp Val Glu Tyr Glu Phe Arg Val Val Ala Thr Asn 
            740                 745                 750         


Pro Ile Gly Thr Gly Asp Pro Ser Thr Pro Ser Arg Met Ile Arg Thr 
        755                 760                 765             


Asn Glu Ala Val Pro Lys Thr Ala Pro Thr Asn Val Ser Gly Arg Ser 
    770                 775                 780                 


Gly Arg Arg His Glu Leu Val Ile Ala Trp Glu Pro Val Ser Glu Glu 
785                 790                 795                 800 


Phe Gln Asn Gly Glu Gly Phe Gly Tyr Ile Val Ala Phe Arg Pro Asn 
                805                 810                 815     


Gly Thr Arg Gly Trp Lys Glu Lys Met Val Thr Ser Ser Glu Ala Ser 
            820                 825                 830         


Lys Phe Ile Tyr Arg Asp Glu Ser Val Pro Pro Leu Thr Pro Phe Glu 
        835                 840                 845             


Val Lys Val Gly Val Tyr Asn Asn Lys Gly Asp Gly Pro Phe Ser Gln 
    850                 855                 860                 


Ile Val Val Ile Cys Ser Ala Glu Gly Glu Pro Ser Ala Ala Pro Thr 
865                 870                 875                 880 


Asp Val Lys Ala Thr Ser Val Ser Val Ser Glu Ile Leu Val Ala Trp 
                885                 890                 895     


Lys His Ile Lys Glu Ser Leu Gly Arg Pro Gln Gly Phe Glu Val 
            900                 905                 910     


<210>  3159
<211>  390
<212>  PRT
<213>  Homo Sapiens

<400>  3159

Met Asn Gly Val Thr Leu Asp Leu Glu Glu Arg Ala Lys Val Thr Ser 
1               5                   10                  15      


Gly Phe Ile Ser Gly Cys Ser Gly His Cys Thr Ser Tyr Gly Thr Asn 
            20                  25                  30          


Cys Glu Asn Gly Gly Lys Cys Leu Glu Arg Tyr His Gly Tyr Ser Cys 
        35                  40                  45              


Asp Cys Ser Asn Thr Ala Tyr Asp Gly Thr Phe Cys Asn Lys Asp Val 
    50                  55                  60                  


Gly Ala Phe Phe Glu Glu Gly Met Trp Leu Arg Tyr Asn Phe Gln Ala 
65                  70                  75                  80  


Pro Ala Thr Asn Ala Arg Asp Ser Ser Ser Arg Val Asp Asn Ala Pro 
                85                  90                  95      


Asp Gln Gln Asn Ser His Pro Asp Leu Ala Gln Glu Glu Ile Arg Phe 
            100                 105                 110         


Ser Phe Ser Thr Thr Lys Ala Pro Cys Ile Leu Leu Tyr Ile Ser Ser 
        115                 120                 125             


Phe Thr Thr Asp Phe Leu Ala Val Leu Val Lys Pro Thr Gly Ser Leu 
    130                 135                 140                 


Gln Ile Arg Tyr Asn Leu Gly Gly Thr Arg Glu Pro Tyr Asn Ile Asp 
145                 150                 155                 160 


Val Asp His Arg Asn Met Ala Asn Gly Gln Pro His Ser Val Asn Ile 
                165                 170                 175     


Thr Arg His Glu Lys Thr Ile Phe Leu Lys Leu Asp His Tyr Pro Ser 
            180                 185                 190         


Val Ser Tyr His Leu Pro Ser Ser Ser Asp Thr Leu Phe Asn Ser Pro 
        195                 200                 205             


Lys Ser Leu Phe Leu Gly Lys Val Ile Glu Thr Gly Lys Ile Asp Gln 
    210                 215                 220                 


Glu Ile His Lys Tyr Asn Thr Pro Gly Phe Thr Gly Cys Leu Ser Arg 
225                 230                 235                 240 


Val Gln Phe Asn Gln Ile Ala Pro Leu Lys Ala Ala Leu Arg Gln Thr 
                245                 250                 255     


Asn Ala Ser Ala His Val His Ile Gln Gly Glu Leu Val Glu Ser Asn 
            260                 265                 270         


Cys Gly Ala Ser Pro Leu Thr Leu Ser Pro Met Ser Ser Ala Thr Asp 
        275                 280                 285             


Pro Trp His Leu Asp His Leu Asp Ser Ala Ser Ala Asp Phe Pro Tyr 
    290                 295                 300                 


Asn Pro Gly Gln Gly Gln Ala Ile Arg Asn Gly Val Asn Arg Asn Ser 
305                 310                 315                 320 


Ala Ile Ile Gly Gly Val Ile Ala Val Val Ile Phe Thr Ile Leu Cys 
                325                 330                 335     


Thr Leu Val Phe Leu Ile Arg Tyr Met Phe Arg His Lys Gly Thr Tyr 
            340                 345                 350         


His Thr Asn Glu Ala Lys Gly Ala Glu Ser Ala Glu Ser Ala Asp Ala 
        355                 360                 365             


Ala Ile Met Asn Asn Asp Pro Asn Phe Thr Glu Thr Ile Asp Glu Ser 
    370                 375                 380                 


Lys Lys Glu Trp Leu Ile 
385                 390 


<210>  3160
<211>  120
<212>  PRT
<213>  Homo Sapiens

<400>  3160

Met Gln Ala Ala Pro Arg Ala Gly Cys Gly Ala Ala Leu Leu Leu Trp 
1               5                   10                  15      


Ile Val Ser Ser Cys Leu Cys Arg Ala Trp Thr Ala Pro Ser Thr Ser 
            20                  25                  30          


Gln Lys Cys Asp Glu Pro Leu Val Ser Gly Leu Pro His Val Ala Phe 
        35                  40                  45              


Ser Ser Ser Ser Ser Ile Ser Gly Ser Tyr Ser Pro Gly Tyr Ala Lys 
    50                  55                  60                  


Ile Asn Lys Arg Gly Gly Ala Gly Gly Trp Ser Pro Ser Asp Ser Asp 
65                  70                  75                  80  


His Tyr Gln Trp Leu Gln Val Asp Phe Gly Asn Arg Lys Gln Ile Ser 
                85                  90                  95      


Ala Ile Ala Thr Gln Gly Arg Tyr Ser Ser Ser Asp Trp Val Thr Gln 
            100                 105                 110         


Tyr Arg Met Leu Tyr Ser Asp Thr 
        115                 120 


<210>  3161
<211>  1331
<212>  PRT
<213>  Homo Sapiens

<400>  3161

Met Gln Ala Ala Pro Arg Ala Gly Cys Gly Ala Ala Leu Leu Leu Trp 
1               5                   10                  15      


Ile Val Ser Ser Cys Leu Cys Arg Ala Trp Thr Ala Pro Ser Thr Ser 
            20                  25                  30          


Gln Lys Cys Asp Glu Pro Leu Val Ser Gly Leu Pro His Val Ala Phe 
        35                  40                  45              


Ser Ser Ser Ser Ser Ile Ser Gly Ser Tyr Ser Pro Gly Tyr Ala Lys 
    50                  55                  60                  


Ile Asn Lys Arg Gly Gly Ala Gly Gly Trp Ser Pro Ser Asp Ser Asp 
65                  70                  75                  80  


His Tyr Gln Trp Leu Gln Val Asp Phe Gly Asn Arg Lys Gln Ile Ser 
                85                  90                  95      


Ala Ile Ala Thr Gln Gly Arg Tyr Ser Ser Ser Asp Trp Val Thr Gln 
            100                 105                 110         


Tyr Arg Met Leu Tyr Ser Asp Thr Gly Arg Asn Trp Lys Pro Tyr His 
        115                 120                 125             


Gln Asp Gly Asn Ile Trp Ala Phe Pro Gly Asn Ile Asn Ser Asp Gly 
    130                 135                 140                 


Val Val Arg His Glu Leu Gln His Pro Ile Ile Ala Arg Tyr Val Arg 
145                 150                 155                 160 


Ile Val Pro Leu Asp Trp Asn Gly Glu Gly Arg Ile Gly Leu Arg Ile 
                165                 170                 175     


Glu Val Tyr Gly Cys Ser Tyr Trp Ala Asp Val Ile Asn Phe Asp Gly 
            180                 185                 190         


His Val Val Leu Pro Tyr Arg Phe Arg Asn Lys Lys Met Lys Thr Leu 
        195                 200                 205             


Lys Asp Val Ile Ala Leu Asn Phe Lys Thr Ser Glu Ser Glu Gly Val 
    210                 215                 220                 


Ile Leu His Gly Glu Gly Gln Gln Gly Asp Tyr Ile Thr Leu Glu Leu 
225                 230                 235                 240 


Lys Lys Ala Lys Leu Val Leu Ser Leu Asn Leu Gly Ser Asn Gln Leu 
                245                 250                 255     


Gly Pro Ile Tyr Gly His Thr Ser Val Met Thr Gly Ser Leu Leu Asp 
            260                 265                 270         


Asp His His Trp His Ser Val Val Ile Glu Arg Gln Gly Arg Ser Ile 
        275                 280                 285             


Asn Leu Thr Leu Asp Arg Ser Met Gln His Phe Arg Thr Asn Gly Glu 
    290                 295                 300                 


Phe Asp Tyr Leu Asp Leu Asp Tyr Glu Ile Thr Phe Gly Gly Ile Pro 
305                 310                 315                 320 


Phe Ser Gly Lys Pro Ser Ser Ser Ser Arg Lys Asn Phe Lys Gly Cys 
                325                 330                 335     


Met Glu Ser Ile Asn Tyr Asn Gly Val Asn Ile Thr Asp Leu Ala Arg 
            340                 345                 350         


Arg Lys Lys Leu Glu Pro Ser Asn Val Gly Asn Leu Ser Phe Ser Cys 
        355                 360                 365             


Val Glu Pro Tyr Thr Val Pro Val Phe Phe Asn Ala Thr Ser Tyr Leu 
    370                 375                 380                 


Glu Val Pro Gly Arg Leu Asn Gln Asp Leu Phe Ser Val Ser Phe Gln 
385                 390                 395                 400 


Phe Arg Thr Trp Asn Pro Asn Gly Leu Leu Val Phe Ser His Phe Ala 
                405                 410                 415     


Asp Asn Leu Gly Asn Val Glu Ile Asp Leu Thr Glu Ser Lys Val Gly 
            420                 425                 430         


Val His Ile Asn Ile Thr Gln Thr Lys Met Ser Gln Ile Asp Ile Ser 
        435                 440                 445             


Ser Gly Ser Gly Leu Asn Asp Gly Gln Trp His Glu Val Arg Phe Leu 
    450                 455                 460                 


Ala Lys Glu Asn Phe Ala Ile Leu Thr Ile Asp Gly Asp Glu Ala Ser 
465                 470                 475                 480 


Ala Val Arg Thr Asn Ser Pro Leu Gln Val Lys Thr Gly Glu Lys Tyr 
                485                 490                 495     


Phe Phe Gly Gly Phe Leu Asn Gln Met Asn Asn Ser Ser His Ser Val 
            500                 505                 510         


Leu Gln Pro Ser Phe Gln Gly Cys Met Gln Leu Ile Gln Val Asp Asp 
        515                 520                 525             


Gln Leu Val Asn Leu Tyr Glu Val Ala Gln Arg Lys Pro Gly Ser Phe 
    530                 535                 540                 


Ala Asn Val Ser Ile Asp Met Cys Ala Ile Ile Asp Arg Cys Val Pro 
545                 550                 555                 560 


Asn His Cys Glu His Gly Gly Lys Cys Ser Gln Thr Trp Asp Ser Phe 
                565                 570                 575     


Lys Cys Thr Cys Asp Glu Thr Gly Tyr Ser Gly Ala Thr Cys His Asn 
            580                 585                 590         


Ser Ile Tyr Glu Pro Ser Cys Glu Ala Tyr Lys His Leu Gly Gln Thr 
        595                 600                 605             


Ser Asn Tyr Tyr Trp Ile Asp Pro Asp Gly Ser Gly Pro Leu Gly Pro 
    610                 615                 620                 


Leu Lys Val Tyr Cys Asn Met Thr Glu Asp Lys Val Trp Thr Ile Val 
625                 630                 635                 640 


Ser His Asp Leu Gln Met Gln Thr Pro Val Val Gly Tyr Asn Pro Glu 
                645                 650                 655     


Lys Tyr Ser Val Thr Gln Leu Val Tyr Ser Ala Ser Met Asp Gln Ile 
            660                 665                 670         


Ser Ala Ile Thr Asp Ser Ala Glu Tyr Cys Glu Gln Tyr Val Ser Tyr 
        675                 680                 685             


Phe Cys Lys Met Ser Arg Leu Leu Asn Thr Pro Asp Gly Ser Pro Tyr 
    690                 695                 700                 


Thr Trp Trp Val Gly Lys Ala Asn Glu Lys His Tyr Tyr Trp Gly Gly 
705                 710                 715                 720 


Ser Gly Pro Gly Ile Gln Lys Cys Ala Cys Gly Ile Glu Arg Asn Cys 
                725                 730                 735     


Thr Asp Pro Lys Tyr Tyr Cys Asn Cys Asp Ala Asp Tyr Lys Gln Trp 
            740                 745                 750         


Arg Lys Asp Ala Gly Phe Leu Ser Tyr Lys Asp His Leu Pro Val Ser 
        755                 760                 765             


Gln Val Val Val Gly Asp Thr Asp Arg Gln Gly Ser Glu Ala Lys Leu 
    770                 775                 780                 


Ser Val Gly Pro Leu Arg Cys Gln Gly Asp Arg Asn Tyr Trp Asn Ala 
785                 790                 795                 800 


Ala Ser Phe Pro Asn Pro Ser Ser Tyr Leu His Phe Ser Thr Phe Gln 
                805                 810                 815     


Gly Glu Thr Ser Ala Asp Ile Ser Phe Tyr Phe Lys Thr Leu Thr Pro 
            820                 825                 830         


Trp Gly Val Phe Leu Glu Asn Met Gly Lys Glu Asp Phe Ile Lys Leu 
        835                 840                 845             


Glu Leu Lys Ser Ala Thr Glu Val Ser Phe Ser Phe Asp Val Gly Asn 
    850                 855                 860                 


Gly Pro Val Glu Ile Val Val Arg Ser Pro Thr Pro Leu Asn Asp Asp 
865                 870                 875                 880 


Gln Trp His Arg Val Thr Ala Glu Arg Asn Val Lys Gln Ala Ser Leu 
                885                 890                 895     


Gln Val Asp Arg Leu Pro Gln Gln Ile Arg Lys Ala Pro Thr Glu Gly 
            900                 905                 910         


His Thr Arg Leu Glu Leu Tyr Ser Gln Leu Phe Val Gly Gly Ala Gly 
        915                 920                 925             


Gly Gln Gln Gly Phe Leu Gly Cys Ile Arg Ser Leu Arg Met Asn Gly 
    930                 935                 940                 


Val Thr Leu Asp Leu Glu Glu Arg Ala Lys Val Thr Ser Gly Phe Ile 
945                 950                 955                 960 


Ser Gly Cys Ser Gly His Cys Thr Ser Tyr Gly Thr Asn Cys Glu Asn 
                965                 970                 975     


Gly Gly Lys Cys Leu Glu Arg Tyr His Gly Tyr Ser Cys Asp Cys Ser 
            980                 985                 990         


Asn Thr Ala Tyr Asp Gly Thr Phe  Cys Asn Lys Asp Val  Gly Ala Phe 
        995                 1000                 1005             


Phe Glu  Glu Gly Met Trp Leu  Arg Tyr Asn Phe Gln  Ala Pro Ala 
    1010                 1015                 1020             


Thr Asn  Ala Arg Asp Ser Ser  Ser Arg Val Asp Asn  Ala Pro Asp 
    1025                 1030                 1035             


Gln Gln  Asn Ser His Pro Asp  Leu Ala Gln Glu Glu  Ile Arg Phe 
    1040                 1045                 1050             


Ser Phe  Ser Thr Thr Lys Ala  Pro Cys Ile Leu Leu  Tyr Ile Ser 
    1055                 1060                 1065             


Ser Phe  Thr Thr Asp Phe Leu  Ala Val Leu Val Lys  Pro Thr Gly 
    1070                 1075                 1080             


Ser Leu  Gln Ile Arg Tyr Asn  Leu Gly Gly Thr Arg  Glu Pro Tyr 
    1085                 1090                 1095             


Asn Ile  Asp Val Asp His Arg  Asn Met Ala Asn Gly  Gln Pro His 
    1100                 1105                 1110             


Ser Val  Asn Ile Thr Arg His  Glu Lys Thr Ile Phe  Leu Lys Leu 
    1115                 1120                 1125             


Asp His  Tyr Pro Ser Val Ser  Tyr His Leu Pro Ser  Ser Ser Asp 
    1130                 1135                 1140             


Thr Leu  Phe Asn Ser Pro Lys  Ser Leu Phe Leu Gly  Lys Val Ile 
    1145                 1150                 1155             


Glu Thr  Gly Lys Ile Asp Gln  Glu Ile His Lys Tyr  Asn Thr Pro 
    1160                 1165                 1170             


Gly Phe  Thr Gly Cys Leu Ser  Arg Val Gln Phe Asn  Gln Ile Ala 
    1175                 1180                 1185             


Pro Leu  Lys Ala Ala Leu Arg  Gln Thr Asn Ala Ser  Ala His Val 
    1190                 1195                 1200             


His Ile  Gln Gly Glu Leu Val  Glu Ser Asn Cys Gly  Ala Ser Pro 
    1205                 1210                 1215             


Leu Thr  Leu Ser Pro Met Ser  Ser Ala Thr Asp Pro  Trp His Leu 
    1220                 1225                 1230             


Asp His  Leu Asp Ser Ala Ser  Ala Asp Phe Pro Tyr  Asn Pro Gly 
    1235                 1240                 1245             


Gln Gly  Gln Ala Ile Arg Asn  Gly Val Asn Arg Asn  Ser Ala Ile 
    1250                 1255                 1260             


Ile Gly  Gly Val Ile Ala Val  Val Ile Phe Thr Ile  Leu Cys Thr 
    1265                 1270                 1275             


Leu Val  Phe Leu Ile Arg Tyr  Met Phe Arg His Lys  Gly Thr Tyr 
    1280                 1285                 1290             


His Thr  Asn Glu Ala Lys Gly  Ala Glu Ser Ala Glu  Ser Ala Asp 
    1295                 1300                 1305             


Ala Ala  Ile Met Asn Asn Asp  Pro Asn Phe Thr Glu  Thr Ile Asp 
    1310                 1315                 1320             


Glu Ser  Lys Lys Glu Trp Leu  Ile 
    1325                 1330     


<210>  3162
<211>  108
<212>  PRT
<213>  Homo Sapiens

<400>  3162

Met Ser Ser Ala Thr Asp Pro Trp His Leu Asp His Leu Asp Ser Ala 
1               5                   10                  15      


Ser Ala Asp Phe Pro Tyr Asn Pro Gly Gln Gly Gln Ala Ile Arg Asn 
            20                  25                  30          


Gly Val Asn Arg Asn Ser Ala Ile Ile Gly Gly Val Ile Ala Val Val 
        35                  40                  45              


Ile Phe Thr Ile Leu Cys Thr Leu Val Phe Leu Ile Arg Tyr Met Phe 
    50                  55                  60                  


Arg His Lys Gly Thr Tyr His Thr Asn Glu Ala Lys Gly Ala Glu Ser 
65                  70                  75                  80  


Ala Glu Ser Ala Asp Ala Ala Ile Met Asn Asn Asp Pro Asn Phe Thr 
                85                  90                  95      


Glu Thr Ile Asp Glu Ser Lys Lys Glu Trp Leu Ile 
            100                 105             


<210>  3163
<211>  1288
<212>  PRT
<213>  Homo Sapiens

<400>  3163

Met Ala Ser Val Ala Trp Ala Val Leu Lys Val Leu Leu Leu Leu Pro 
1               5                   10                  15      


Thr Gln Thr Trp Ser Pro Val Gly Ala Gly Asn Pro Pro Asp Cys Asp 
            20                  25                  30          


Ala Pro Leu Ala Ser Ala Leu Pro Arg Ser Ser Phe Ser Ser Ser Ser 
        35                  40                  45              


Glu Leu Ser Ser Ser His Gly Pro Gly Phe Ser Arg Leu Asn Arg Arg 
    50                  55                  60                  


Asp Gly Ala Gly Gly Trp Thr Pro Leu Val Ser Asn Lys Tyr Gln Trp 
65                  70                  75                  80  


Leu Gln Ile Asp Leu Gly Glu Arg Met Glu Val Thr Ala Val Ala Thr 
                85                  90                  95      


Gln Gly Gly Tyr Gly Ser Ser Asp Trp Val Thr Ser Tyr Leu Leu Met 
            100                 105                 110         


Phe Ser Asp Gly Gly Arg Asn Trp Lys Gln Tyr Arg Arg Glu Glu Ser 
        115                 120                 125             


Ile Trp Gly Phe Pro Gly Asn Thr Asn Ala Asp Ser Val Val His Tyr 
    130                 135                 140                 


Arg Leu Gln Pro Pro Phe Glu Ala Arg Phe Leu Arg Phe Leu Pro Leu 
145                 150                 155                 160 


Ala Trp Asn Pro Arg Gly Arg Ile Gly Met Arg Ile Glu Val Tyr Gly 
                165                 170                 175     


Cys Ala Tyr Lys Ser Glu Val Val Tyr Phe Asp Gly Gln Ser Ala Leu 
            180                 185                 190         


Leu Tyr Arg Leu Asp Lys Lys Pro Leu Lys Pro Ile Arg Asp Val Ile 
        195                 200                 205             


Ser Leu Lys Phe Lys Ala Met Gln Ser Asn Gly Ile Leu Leu His Arg 
    210                 215                 220                 


Glu Gly Gln His Gly Asn His Ile Thr Leu Glu Leu Ile Lys Gly Lys 
225                 230                 235                 240 


Leu Val Phe Phe Leu Asn Ser Gly Asn Ala Lys Leu Pro Ser Thr Ile 
                245                 250                 255     


Ala Pro Val Thr Leu Thr Leu Gly Ser Leu Leu Asp Asp Gln His Trp 
            260                 265                 270         


His Ser Val Leu Ile Glu Leu Leu Asp Thr Gln Val Asn Phe Thr Val 
        275                 280                 285             


Asp Lys His Thr His His Phe Gln Ala Lys Gly Asp Ser Ser Tyr Leu 
    290                 295                 300                 


Asp Leu Asn Phe Glu Ile Ser Phe Gly Gly Ile Pro Thr Pro Gly Arg 
305                 310                 315                 320 


Ser Arg Ala Phe Arg Arg Lys Ser Phe His Gly Cys Leu Glu Asn Leu 
                325                 330                 335     


Tyr Tyr Asn Gly Val Asp Val Thr Glu Leu Ala Lys Lys His Lys Pro 
            340                 345                 350         


Gln Ile Leu Met Met Gly Asn Val Ser Phe Ser Cys Pro Gln Pro Gln 
        355                 360                 365             


Thr Val Pro Val Thr Phe Leu Ser Ser Arg Ser Tyr Leu Ala Leu Pro 
    370                 375                 380                 


Gly Asn Ser Gly Glu Asp Lys Val Ser Val Thr Phe Gln Phe Arg Thr 
385                 390                 395                 400 


Trp Asn Arg Ala Gly His Leu Leu Phe Gly Glu Leu Arg Arg Gly Ser 
                405                 410                 415     


Gly Ser Phe Val Leu Phe Leu Lys Asp Gly Lys Leu Lys Leu Ser Leu 
            420                 425                 430         


Phe Gln Pro Gly Gln Ser Pro Arg Asn Val Thr Ala Gly Ala Gly Leu 
        435                 440                 445             


Asn Asp Gly Gln Trp His Ser Val Ser Phe Ser Ala Lys Trp Ser His 
    450                 455                 460                 


Met Asn Val Val Val Asp Asp Asp Thr Ala Val Gln Pro Leu Val Ala 
465                 470                 475                 480 


Val Leu Ile Asp Ser Gly Asp Thr Tyr Tyr Phe Gly Gly Cys Leu Asp 
                485                 490                 495     


Asn Ser Ser Gly Ser Gly Cys Lys Ser Pro Leu Gly Gly Phe Gln Gly 
            500                 505                 510         


Cys Leu Arg Leu Ile Thr Ile Gly Asp Lys Ala Val Asp Pro Ile Leu 
        515                 520                 525             


Val Gln Gln Gly Ala Leu Gly Ser Phe Arg Asp Leu Gln Ile Asp Ser 
    530                 535                 540                 


Cys Gly Ile Thr Asp Arg Cys Leu Pro Ser Tyr Cys Glu His Gly Gly 
545                 550                 555                 560 


Glu Cys Ser Gln Ser Trp Asp Thr Phe Ser Cys Asp Cys Leu Gly Thr 
                565                 570                 575     


Gly Tyr Thr Gly Glu Thr Cys His Ser Ser Leu Tyr Glu Gln Ser Cys 
            580                 585                 590         


Glu Ala His Lys His Arg Gly Asn Pro Ser Gly Leu Tyr Tyr Ile Asp 
        595                 600                 605             


Ala Asp Gly Ser Gly Pro Leu Gly Pro Phe Leu Val Tyr Cys Asn Met 
    610                 615                 620                 


Thr Ala Asp Ala Ala Trp Thr Val Val Gln His Gly Gly Pro Asp Ala 
625                 630                 635                 640 


Val Thr Leu Arg Gly Ala Pro Ser Gly His Pro Arg Ser Ala Val Ser 
                645                 650                 655     


Phe Ala Tyr Ala Ala Gly Ala Gly Gln Leu Arg Ser Ala Val Asn Leu 
            660                 665                 670         


Ala Glu Arg Cys Glu Gln Arg Leu Ala Leu Arg Cys Gly Thr Ala Arg 
        675                 680                 685             


Arg Pro Asp Ser Arg Asp Gly Thr Pro Leu Ser Trp Trp Val Gly Arg 
    690                 695                 700                 


Thr Asn Glu Thr His Thr Ser Trp Gly Gly Ser Leu Pro Asp Ala Gln 
705                 710                 715                 720 


Lys Cys Thr Cys Gly Leu Glu Gly Asn Cys Ile Asp Ser Gln Tyr Tyr 
                725                 730                 735     


Cys Asn Cys Asp Ala Gly Arg Asn Glu Trp Thr Ser Asp Thr Ile Val 
            740                 745                 750         


Leu Ser Gln Lys Glu His Leu Pro Val Thr Gln Ile Val Met Thr Asp 
        755                 760                 765             


Ala Gly Arg Pro His Ser Glu Ala Ala Tyr Thr Leu Gly Pro Leu Leu 
    770                 775                 780                 


Cys Arg Gly Asp Gln Ser Phe Trp Asn Ser Ala Ser Phe Asn Thr Glu 
785                 790                 795                 800 


Thr Ser Tyr Leu His Phe Pro Ala Phe His Gly Glu Leu Thr Ala Asp 
                805                 810                 815     


Val Cys Phe Phe Phe Lys Thr Thr Val Ser Ser Gly Val Phe Met Glu 
            820                 825                 830         


Asn Leu Gly Ile Thr Asp Phe Ile Arg Ile Glu Leu Arg Ala Pro Thr 
        835                 840                 845             


Glu Val Thr Phe Ser Phe Asp Val Gly Asn Gly Pro Cys Glu Val Thr 
    850                 855                 860                 


Val Gln Ser Pro Thr Pro Phe Asn Asp Asn Gln Trp His His Val Arg 
865                 870                 875                 880 


Ala Glu Arg Asn Val Lys Gly Ala Ser Leu Gln Val Asp Gln Leu Pro 
                885                 890                 895     


Gln Lys Met Gln Pro Ala Pro Ala Asp Gly His Val Arg Leu Gln Leu 
            900                 905                 910         


Asn Ser Gln Leu Phe Ile Gly Gly Thr Ala Thr Arg Gln Arg Gly Phe 
        915                 920                 925             


Leu Gly Cys Ile Arg Ser Leu Gln Leu Asn Gly Val Ala Leu Asp Leu 
    930                 935                 940                 


Glu Glu Arg Ala Thr Val Thr Pro Gly Val Glu Pro Gly Cys Ala Gly 
945                 950                 955                 960 


His Cys Ser Thr Tyr Gly His Leu Cys Arg Asn Gly Gly Arg Cys Arg 
                965                 970                 975     


Glu Lys Arg Arg Gly Val Thr Cys Asp Cys Ala Phe Ser Ala Tyr Asp 
            980                 985                 990         


Gly Pro Phe Cys Ser Asn Glu Ile  Ser Ala Tyr Phe Ala  Thr Gly Ser 
        995                 1000                 1005             


Ser Met  Thr Tyr His Phe Gln  Glu His Tyr Thr Leu  Ser Glu Asn 
    1010                 1015                 1020             


Ser Ser  Ser Leu Val Ser Ser  Leu His Arg Asp Val  Thr Leu Thr 
    1025                 1030                 1035             


Arg Glu  Met Ile Thr Leu Ser  Phe Arg Thr Thr Arg  Thr Pro Ser 
    1040                 1045                 1050             


Leu Leu  Leu Tyr Val Ser Ser  Phe Tyr Glu Glu Tyr  Leu Ser Val 
    1055                 1060                 1065             


Ile Leu  Ala Asn Asn Gly Ser  Leu Gln Ile Arg Tyr  Lys Leu Asp 
    1070                 1075                 1080             


Arg His  Gln Asn Pro Asp Ala  Phe Thr Phe Asp Phe  Lys Asn Met 
    1085                 1090                 1095             


Ala Asp  Gly Gln Leu His Gln  Val Lys Ile Asn Arg  Glu Glu Ala 
    1100                 1105                 1110             


Val Val  Met Val Glu Val Asn  Gln Ser Thr Lys Lys  Gln Val Ile 
    1115                 1120                 1125             


Leu Ser  Ser Gly Thr Glu Phe  Asn Ala Val Lys Ser  Leu Ile Leu 
    1130                 1135                 1140             


Gly Lys  Val Leu Glu Ala Ala  Gly Ala Asp Pro Asp  Thr Arg Arg 
    1145                 1150                 1155             


Ala Ala  Thr Ser Gly Phe Thr  Gly Cys Leu Ser Ala  Val Arg Phe 
    1160                 1165                 1170             


Gly Arg  Ala Ala Pro Leu Lys  Ala Ala Leu Arg Pro  Ser Gly Pro 
    1175                 1180                 1185             


Ser Arg  Val Thr Val Arg Gly  His Val Ala Pro Met  Ala Arg Cys 
    1190                 1195                 1200             


Ala Ala  Gly Ala Ala Ser Gly  Ser Pro Ala Arg Glu  Leu Ala Pro 
    1205                 1210                 1215             


Arg Leu  Ala Gly Gly Ala Gly  Arg Ser Gly Pro Ala  Asp Glu Gly 
    1220                 1225                 1230             


Glu Pro  Leu Val Asn Ala Asp  Arg Arg Asp Ser Ala  Val Ile Gly 
    1235                 1240                 1245             


Gly Val  Ile Ala Val Val Ile  Phe Ile Leu Leu Cys  Ile Thr Ala 
    1250                 1255                 1260             


Ile Ala  Ile Arg Ile Tyr Gln  Gln Arg Lys Leu Arg  Lys Glu Asn 
    1265                 1270                 1275             


Glu Ser  Lys Val Ser Lys Lys  Glu Glu Cys 
    1280                 1285             


<210>  3164
<211>  1207
<212>  PRT
<213>  Homo Sapiens

<400>  3164

Met Ala Ser Val Ala Trp Ala Val Leu Lys Val Leu Leu Leu Leu Pro 
1               5                   10                  15      


Thr Gln Thr Trp Ser Pro Val Gly Ala Gly Asn Pro Pro Asp Cys Asp 
            20                  25                  30          


Ala Pro Leu Ala Ser Ala Leu Pro Arg Ser Ser Phe Ser Ser Ser Ser 
        35                  40                  45              


Glu Leu Ser Ser Ser His Gly Pro Gly Phe Ser Arg Leu Asn Arg Arg 
    50                  55                  60                  


Asp Gly Ala Gly Gly Trp Thr Pro Leu Val Ser Asn Lys Tyr Gln Trp 
65                  70                  75                  80  


Leu Gln Ile Asp Leu Gly Glu Arg Met Glu Val Thr Ala Val Ala Thr 
                85                  90                  95      


Gln Gly Gly Tyr Gly Ser Ser Asp Trp Val Thr Ser Tyr Leu Leu Met 
            100                 105                 110         


Phe Ser Asp Gly Gly Arg Asn Trp Lys Gln Tyr Arg Arg Glu Glu Ser 
        115                 120                 125             


Ile Trp Gly Phe Pro Gly Asn Thr Asn Ala Asp Ser Val Val His Tyr 
    130                 135                 140                 


Arg Leu Gln Pro Pro Phe Glu Ala Arg Phe Leu Arg Phe Leu Pro Leu 
145                 150                 155                 160 


Ala Trp Asn Pro Arg Gly Arg Ile Gly Met Arg Ile Glu Val Tyr Gly 
                165                 170                 175     


Cys Ala Tyr Lys Ser Glu Val Val Tyr Phe Asp Gly Gln Ser Ala Leu 
            180                 185                 190         


Leu Tyr Arg Leu Asp Lys Lys Pro Leu Lys Pro Ile Arg Asp Val Ile 
        195                 200                 205             


Ser Leu Lys Phe Lys Ala Met Gln Ser Asn Gly Ile Leu Leu His Arg 
    210                 215                 220                 


Glu Gly Gln His Gly Asn His Ile Thr Leu Glu Leu Ile Lys Gly Lys 
225                 230                 235                 240 


Leu Val Phe Phe Leu Asn Ser Gly Asn Ala Lys Leu Pro Ser Thr Ile 
                245                 250                 255     


Ala Pro Val Thr Leu Thr Leu Gly Ser Leu Leu Asp Asp Gln His Trp 
            260                 265                 270         


His Ser Val Leu Ile Glu Leu Leu Asp Thr Gln Val Asn Phe Thr Val 
        275                 280                 285             


Asp Lys His Thr His His Phe Gln Ala Lys Gly Asp Ser Ser Tyr Leu 
    290                 295                 300                 


Asp Leu Asn Phe Glu Ile Ser Phe Gly Gly Ile Pro Thr Pro Gly Arg 
305                 310                 315                 320 


Ser Arg Ala Phe Arg Arg Lys Ser Phe His Gly Cys Leu Glu Asn Leu 
                325                 330                 335     


Tyr Tyr Asn Gly Val Asp Val Thr Glu Leu Ala Lys Lys His Lys Pro 
            340                 345                 350         


Gln Ile Leu Met Met Gly Asn Val Ser Phe Ser Cys Pro Gln Pro Gln 
        355                 360                 365             


Thr Val Pro Val Thr Phe Leu Ser Ser Arg Ser Tyr Leu Ala Leu Pro 
    370                 375                 380                 


Gly Asn Ser Gly Glu Asp Lys Val Ser Val Thr Phe Gln Phe Arg Thr 
385                 390                 395                 400 


Trp Asn Arg Ala Gly His Leu Leu Phe Gly Glu Leu Arg Arg Gly Ser 
                405                 410                 415     


Gly Ser Phe Val Leu Phe Leu Lys Asp Gly Lys Leu Lys Leu Ser Leu 
            420                 425                 430         


Phe Gln Pro Gly Gln Ser Pro Arg Asn Val Thr Ala Gly Ala Gly Leu 
        435                 440                 445             


Asn Asp Gly Gln Trp His Ser Val Ser Phe Ser Ala Lys Trp Ser His 
    450                 455                 460                 


Met Asn Val Val Val Asp Asp Asp Thr Ala Val Gln Pro Leu Val Ala 
465                 470                 475                 480 


Val Leu Ile Asp Ser Gly Asp Thr Tyr Tyr Phe Gly Gly Cys Leu Asp 
                485                 490                 495     


Asn Ser Ser Gly Ser Gly Cys Lys Ser Pro Leu Gly Gly Phe Gln Gly 
            500                 505                 510         


Cys Leu Arg Leu Ile Thr Ile Gly Asp Lys Ala Val Asp Pro Ile Leu 
        515                 520                 525             


Val Gln Gln Gly Ala Leu Gly Ser Phe Arg Asp Leu Gln Ile Asp Ser 
    530                 535                 540                 


Cys Gly Ile Thr Asp Arg Cys Leu Pro Ser Tyr Cys Glu His Gly Gly 
545                 550                 555                 560 


Glu Cys Ser Gln Ser Trp Asp Thr Phe Ser Cys Asp Cys Leu Gly Thr 
                565                 570                 575     


Gly Tyr Thr Gly Glu Thr Cys His Ser Ser Leu Tyr Glu Gln Ser Cys 
            580                 585                 590         


Glu Ala His Lys His Arg Gly Asn Pro Ser Gly Leu Tyr Tyr Ile Asp 
        595                 600                 605             


Ala Asp Gly Ser Gly Pro Leu Gly Pro Phe Leu Val Tyr Cys Asn Met 
    610                 615                 620                 


Thr Asp Ala Ala Trp Thr Val Val Gln His Gly Gly Pro Asp Ala Val 
625                 630                 635                 640 


Thr Leu Arg Gly Ala Pro Ser Gly His Pro Arg Ser Ala Val Ser Phe 
                645                 650                 655     


Ala Tyr Ala Ala Gly Ala Gly Gln Leu Arg Ser Ala Val Asn Leu Ala 
            660                 665                 670         


Glu Arg Cys Glu Gln Arg Leu Ala Leu Arg Cys Gly Thr Ala Arg Arg 
        675                 680                 685             


Pro Asp Ser Arg Asp Gly Thr Pro Leu Ser Trp Trp Val Gly Arg Thr 
    690                 695                 700                 


Asn Glu Thr His Thr Ser Trp Gly Gly Ser Leu Pro Asp Ala Gln Lys 
705                 710                 715                 720 


Cys Thr Cys Gly Leu Glu Gly Asn Cys Ile Asp Ser Gln Tyr Tyr Cys 
                725                 730                 735     


Asn Cys Asp Ala Gly Arg Asn Glu Trp Thr Ser Asp Thr Ile Val Leu 
            740                 745                 750         


Ser Gln Lys Glu His Leu Pro Val Thr Gln Ile Val Met Thr Asp Ala 
        755                 760                 765             


Gly Arg Pro His Ser Glu Ala Ala Tyr Thr Leu Gly Pro Leu Leu Cys 
    770                 775                 780                 


Arg Gly Asp Gln Ser Phe Trp Asn Ser Ala Ser Phe Asn Thr Glu Thr 
785                 790                 795                 800 


Ser Tyr Leu His Phe Pro Ala Phe His Gly Glu Leu Thr Ala Asp Val 
                805                 810                 815     


Cys Phe Phe Phe Lys Thr Thr Val Ser Ser Gly Val Phe Met Glu Asn 
            820                 825                 830         


Leu Gly Ile Thr Asp Phe Ile Arg Ile Glu Leu Arg Ala Pro Thr Glu 
        835                 840                 845             


Val Thr Phe Ser Phe Asp Val Gly Asn Gly Pro Cys Glu Val Thr Val 
    850                 855                 860                 


Gln Ser Pro Thr Pro Phe Asn Asp Asn Gln Trp His His Val Arg Ala 
865                 870                 875                 880 


Glu Arg Asn Val Lys Gly Ala Ser Leu Gln Val Asp Gln Leu Pro Gln 
                885                 890                 895     


Lys Met Gln Pro Ala Pro Ala Asp Gly His Val Arg Leu Gln Leu Asn 
            900                 905                 910         


Ser Gln Leu Phe Ile Glu Ile Ser Ala Tyr Phe Ala Thr Gly Ser Ser 
        915                 920                 925             


Met Thr Tyr His Phe Gln Glu His Tyr Thr Leu Ser Glu Asn Ser Ser 
    930                 935                 940                 


Ser Leu Val Ser Ser Leu His Arg Asp Val Thr Leu Thr Arg Glu Met 
945                 950                 955                 960 


Ile Thr Leu Ser Phe Arg Thr Thr Arg Thr Pro Ser Leu Leu Leu Tyr 
                965                 970                 975     


Val Ser Ser Phe Tyr Glu Glu Tyr Leu Ser Val Ile Leu Ala Asn Asn 
            980                 985                 990         


Gly Ser Leu Gln Ile Arg Tyr Lys  Leu Asp Arg His Gln  Asn Pro Asp 
        995                 1000                 1005             


Ala Phe  Thr Phe Asp Phe Lys  Asn Met Ala Asp Gly  Gln Leu His 
    1010                 1015                 1020             


Gln Val  Lys Ile Asn Arg Glu  Glu Ala Val Val Met  Val Glu Val 
    1025                 1030                 1035             


Asn Gln  Ser Thr Lys Lys Gln  Val Ile Leu Ser Ser  Gly Thr Glu 
    1040                 1045                 1050             


Phe Asn  Ala Val Lys Ser Leu  Ile Leu Gly Lys Val  Leu Glu Ala 
    1055                 1060                 1065             


Ala Gly  Ala Asp Pro Asp Thr  Arg Arg Ala Ala Thr  Ser Gly Phe 
    1070                 1075                 1080             


Thr Gly  Cys Leu Ser Ala Val  Arg Phe Gly Arg Ala  Ala Pro Leu 
    1085                 1090                 1095             


Lys Ala  Ala Leu Arg Pro Ser  Gly Pro Ser Arg Val  Thr Val Arg 
    1100                 1105                 1110             


Gly His  Val Ala Pro Met Ala  Arg Cys Ala Ala Gly  Ala Ala Ser 
    1115                 1120                 1125             


Gly Ser  Pro Ala Arg Glu Leu  Ala Pro Arg Leu Ala  Gly Gly Ala 
    1130                 1135                 1140             


Gly Arg  Ser Gly Pro Ala Asp  Glu Gly Glu Pro Leu  Val Asn Ala 
    1145                 1150                 1155             


Asp Arg  Arg Asp Ser Ala Val  Ile Gly Gly Val Ile  Ala Val Val 
    1160                 1165                 1170             


Ile Phe  Ile Leu Leu Cys Ile  Thr Ala Ile Ala Ile  Arg Ile Tyr 
    1175                 1180                 1185             


Gln Gln  Arg Lys Leu Arg Lys  Glu Asn Glu Ser Lys  Val Ser Lys 
    1190                 1195                 1200             


Lys Glu  Glu Cys 
    1205         


<210>  3165
<211>  745
<212>  PRT
<213>  Homo Sapiens

<400>  3165

Met Ala Ser Val Ala Trp Ala Val Leu Lys Val Leu Leu Leu Leu Pro 
1               5                   10                  15      


Thr Gln Thr Trp Ser Pro Val Gly Ala Gly Asn Pro Pro Asp Cys Asp 
            20                  25                  30          


Ala Pro Leu Ala Ser Ala Leu Pro Arg Ser Ser Phe Ser Ser Ser Ser 
        35                  40                  45              


Glu Leu Ser Ser Ser His Gly Pro Gly Phe Ser Arg Leu Asn Arg Arg 
    50                  55                  60                  


Asp Gly Ala Gly Gly Trp Thr Pro Leu Val Ser Asn Lys Tyr Gln Trp 
65                  70                  75                  80  


Leu Gln Ile Asp Leu Gly Glu Arg Met Glu Val Thr Ala Val Ala Thr 
                85                  90                  95      


Gln Gly Gly Tyr Gly Ser Ser Asp Trp Val Thr Ser Tyr Leu Leu Met 
            100                 105                 110         


Phe Ser Asp Gly Gly Arg Asn Trp Lys Gln Tyr Arg Arg Glu Glu Ser 
        115                 120                 125             


Ile Trp Gly Phe Pro Gly Asn Thr Asn Ala Asp Ser Val Val His Tyr 
    130                 135                 140                 


Arg Leu Gln Pro Pro Phe Glu Ala Arg Phe Leu Arg Phe Leu Pro Leu 
145                 150                 155                 160 


Ala Trp Asn Pro Arg Gly Arg Ile Gly Met Arg Ile Glu Val Tyr Gly 
                165                 170                 175     


Cys Ala Tyr Lys Ser Glu Val Val Tyr Phe Asp Gly Gln Ser Ala Leu 
            180                 185                 190         


Leu Tyr Arg Leu Asp Lys Lys Pro Leu Lys Pro Ile Arg Asp Val Ile 
        195                 200                 205             


Ser Leu Lys Phe Lys Ala Met Gln Ser Asn Gly Ile Leu Leu His Arg 
    210                 215                 220                 


Glu Gly Gln His Gly Asn His Ile Thr Leu Glu Leu Ile Lys Gly Lys 
225                 230                 235                 240 


Leu Val Phe Phe Leu Asn Ser Gly Asn Ala Lys Leu Pro Ser Thr Ile 
                245                 250                 255     


Ala Pro Val Thr Leu Thr Leu Gly Ser Leu Leu Asp Asp Gln His Trp 
            260                 265                 270         


His Ser Val Leu Ile Glu Leu Leu Asp Thr Gln Val Asn Phe Thr Val 
        275                 280                 285             


Asp Lys His Thr His His Phe Gln Ala Lys Gly Asp Ser Ser Tyr Leu 
    290                 295                 300                 


Asp Leu Asn Phe Glu Ile Ser Phe Gly Gly Ile Pro Thr Pro Gly Arg 
305                 310                 315                 320 


Ser Arg Ala Phe Arg Arg Lys Ser Phe His Gly Cys Leu Glu Asn Leu 
                325                 330                 335     


Tyr Tyr Asn Gly Val Asp Val Thr Glu Leu Ala Lys Lys His Lys Pro 
            340                 345                 350         


Gln Ile Leu Met Met Gly Asn Val Ser Phe Ser Cys Pro Gln Pro Gln 
        355                 360                 365             


Thr Val Pro Val Thr Phe Leu Ser Ser Arg Ser Tyr Leu Ala Leu Pro 
    370                 375                 380                 


Gly Asn Ser Gly Glu Asp Lys Val Ser Val Thr Phe Gln Phe Arg Thr 
385                 390                 395                 400 


Trp Asn Arg Ala Gly His Leu Leu Phe Gly Glu Leu Arg Arg Gly Ser 
                405                 410                 415     


Gly Ser Phe Val Leu Phe Leu Lys Asp Gly Lys Leu Lys Leu Ser Leu 
            420                 425                 430         


Phe Gln Pro Gly Gln Ser Pro Arg Asn Val Thr Ala Gly Ala Gly Leu 
        435                 440                 445             


Asn Asp Gly Gln Trp His Ser Val Ser Phe Ser Ala Lys Trp Ser His 
    450                 455                 460                 


Met Asn Val Val Val Asp Asp Asp Thr Ala Val Gln Pro Leu Val Ala 
465                 470                 475                 480 


Val Leu Ile Asp Ser Gly Asp Thr Tyr Tyr Phe Gly Gly Cys Leu Asp 
                485                 490                 495     


Asn Ser Ser Gly Ser Gly Cys Lys Ser Pro Leu Gly Gly Phe Gln Gly 
            500                 505                 510         


Cys Leu Arg Leu Ile Thr Ile Gly Asp Lys Ala Val Asp Pro Ile Leu 
        515                 520                 525             


Val Gln Gln Gly Ala Leu Gly Ser Phe Arg Asp Leu Gln Ile Asp Ser 
    530                 535                 540                 


Cys Gly Ile Thr Asp Arg Cys Leu Pro Ser Tyr Cys Glu His Gly Gly 
545                 550                 555                 560 


Glu Cys Ser Gln Ser Trp Asp Thr Phe Ser Cys Asp Cys Leu Gly Thr 
                565                 570                 575     


Gly Tyr Thr Gly Glu Thr Cys His Ser Ser Leu Tyr Glu Gln Ser Cys 
            580                 585                 590         


Glu Ala His Lys His Arg Gly Asn Pro Ser Gly Leu Tyr Tyr Ile Asp 
        595                 600                 605             


Ala Asp Gly Ser Gly Pro Leu Gly Pro Phe Leu Val Tyr Cys Asn Met 
    610                 615                 620                 


Thr Asp Ala Ala Trp Thr Val Val Gln His Gly Gly Pro Asp Ala Val 
625                 630                 635                 640 


Thr Leu Arg Gly Ala Pro Ser Gly His Pro Arg Ser Ala Val Ser Phe 
                645                 650                 655     


Ala Tyr Ala Ala Gly Ala Gly Gln Leu Arg Ser Ala Val Asn Leu Ala 
            660                 665                 670         


Glu Arg Cys Glu Gln Arg Leu Ala Leu Arg Cys Gly Thr Ala Arg Arg 
        675                 680                 685             


Pro Asp Ser Arg Asp Gly Thr Pro Leu Ser Trp Trp Val Gly Arg Thr 
    690                 695                 700                 


Asn Glu Thr His Thr Ser Trp Gly Gly Ser Leu Pro Asp Ala Gln Lys 
705                 710                 715                 720 


Cys Thr Cys Gly Leu Glu Gly Asn Cys Ile Asp Ser Gln Tyr Tyr Cys 
                725                 730                 735     


Asn Cys Asp Ala Gly Arg Asn Glu Trp 
            740                 745 


<210>  3166
<211>  604
<212>  PRT
<213>  Homo Sapiens

<400>  3166

Met Ala Ser Val Ala Trp Ala Val Leu Lys Val Leu Leu Leu Leu Pro 
1               5                   10                  15      


Thr Gln Thr Trp Ser Pro Val Gly Ala Gly Asn Pro Pro Asp Cys Asp 
            20                  25                  30          


Ala Pro Leu Ala Ser Ala Leu Pro Arg Ser Ser Phe Ser Ser Ser Ser 
        35                  40                  45              


Glu Leu Ser Ser Ser His Gly Pro Gly Phe Ser Arg Leu Asn Arg Arg 
    50                  55                  60                  


Asp Gly Ala Gly Gly Trp Thr Pro Leu Val Ser Asn Lys Tyr Gln Trp 
65                  70                  75                  80  


Leu Gln Ile Asp Leu Gly Glu Arg Met Glu Val Thr Ala Val Ala Thr 
                85                  90                  95      


Gln Gly Gly Tyr Gly Ser Ser Asp Trp Val Thr Ser Tyr Leu Leu Met 
            100                 105                 110         


Phe Ser Asp Gly Gly Arg Asn Trp Lys Gln Tyr Arg Arg Glu Glu Ser 
        115                 120                 125             


Ile Trp Gly Phe Pro Gly Asn Thr Asn Ala Asp Ser Val Val His Tyr 
    130                 135                 140                 


Arg Leu Gln Pro Pro Phe Glu Ala Arg Phe Leu Arg Phe Leu Pro Leu 
145                 150                 155                 160 


Ala Trp Asn Pro Arg Gly Arg Ile Gly Met Arg Ile Glu Val Tyr Gly 
                165                 170                 175     


Cys Ala Tyr Lys Ser Glu Val Val Tyr Phe Asp Gly Gln Ser Ala Leu 
            180                 185                 190         


Leu Tyr Arg Leu Asp Lys Lys Pro Leu Lys Pro Ile Arg Asp Val Ile 
        195                 200                 205             


Ser Leu Lys Phe Lys Ala Met Gln Ser Asn Gly Ile Leu Leu His Arg 
    210                 215                 220                 


Glu Gly Gln His Gly Asn His Ile Thr Leu Glu Leu Ile Lys Gly Lys 
225                 230                 235                 240 


Leu Val Phe Phe Leu Asn Ser Gly Asn Ala Lys Leu Pro Ser Thr Ile 
                245                 250                 255     


Ala Pro Val Thr Leu Thr Leu Gly Ser Leu Leu Asp Asp Gln His Trp 
            260                 265                 270         


His Ser Val Leu Ile Glu Leu Leu Asp Thr Gln Val Asn Phe Thr Val 
        275                 280                 285             


Asp Lys His Thr His His Phe Gln Ala Lys Gly Asp Ser Ser Tyr Leu 
    290                 295                 300                 


Asp Leu Asn Phe Glu Ile Ser Phe Gly Gly Ile Pro Thr Pro Gly Arg 
305                 310                 315                 320 


Ser Arg Ala Phe Arg Arg Lys Ser Phe His Gly Cys Leu Glu Asn Leu 
                325                 330                 335     


Tyr Tyr Asn Gly Val Asp Val Thr Glu Leu Ala Lys Lys His Lys Pro 
            340                 345                 350         


Gln Ile Leu Met Met Gly Asn Val Ser Phe Ser Cys Pro Gln Pro Gln 
        355                 360                 365             


Thr Val Pro Val Thr Phe Leu Ser Ser Arg Ser Tyr Leu Ala Leu Pro 
    370                 375                 380                 


Gly Asn Ser Gly Glu Asp Lys Val Ser Val Thr Phe Gln Phe Arg Thr 
385                 390                 395                 400 


Trp Asn Arg Ala Gly His Leu Leu Phe Gly Glu Leu Arg Arg Gly Ser 
                405                 410                 415     


Gly Ser Phe Val Leu Phe Leu Lys Asp Gly Lys Leu Lys Leu Ser Leu 
            420                 425                 430         


Phe Gln Pro Gly Gln Ser Pro Arg Asn Val Thr Ala Gly Ala Gly Leu 
        435                 440                 445             


Asn Asp Gly Gln Trp His Ser Val Ser Phe Ser Ala Lys Trp Ser His 
    450                 455                 460                 


Met Asn Val Val Val Asp Asp Asp Thr Ala Val Gln Pro Leu Val Ala 
465                 470                 475                 480 


Val Leu Ile Asp Ser Gly Asp Thr Tyr Tyr Phe Gly Ala Leu Tyr Glu 
                485                 490                 495     


Gln Ser Cys Glu Ala His Lys His Arg Gly Asn Pro Ser Gly Leu Tyr 
            500                 505                 510         


Tyr Ile Asp Ala Asp Gly Ser Gly Pro Leu Gly Pro Phe Leu Val Tyr 
        515                 520                 525             


Cys Asn Met Thr Asp Ala Ala Trp Thr Val Val Gln His Gly Gly Pro 
    530                 535                 540                 


Asp Ala Val Thr Leu Arg Gly Ala Pro Ser Gly His Pro Arg Ser Ala 
545                 550                 555                 560 


Val Ser Phe Ala Tyr Ala Ala Gly Ala Gly Gln Leu Arg Ser Ala Val 
                565                 570                 575     


Asn Leu Ala Glu Arg Cys Glu Gln Arg Leu Ala Leu Arg Cys Gly Thr 
            580                 585                 590         


Ala Arg Arg Pro Asp Ser Arg Gly Leu Val Thr Gln 
        595                 600                 


<210>  3167
<211>  1039
<212>  PRT
<213>  Homo Sapiens

<400>  3167

Met Glu Val Thr Ala Val Ala Thr Gln Gly Gly Tyr Gly Ser Ser Asp 
1               5                   10                  15      


Trp Val Thr Ser Tyr Leu Leu Met Phe Ser Asp Gly Gly Arg Asn Trp 
            20                  25                  30          


Lys Gln Tyr Arg Arg Glu Glu Ser Ile Trp Gly Phe Pro Gly Asn Thr 
        35                  40                  45              


Asn Ala Asp Ser Val Val His Tyr Arg Leu Gln Pro Pro Phe Glu Ala 
    50                  55                  60                  


Arg Phe Leu Arg Phe Leu Pro Leu Ala Trp Asn Pro Arg Gly Arg Ile 
65                  70                  75                  80  


Gly Met Arg Ile Glu Val Tyr Gly Cys Ala Tyr Lys Ser Glu Val Val 
                85                  90                  95      


Tyr Phe Asp Gly Gln Ser Ala Leu Leu Tyr Arg Leu Asp Lys Lys Pro 
            100                 105                 110         


Leu Lys Pro Ile Arg Asp Val Ile Ser Leu Lys Phe Lys Ala Met Gln 
        115                 120                 125             


Ser Asn Gly Ile Leu Leu His Arg Glu Gly Gln His Gly Asn His Ile 
    130                 135                 140                 


Thr Leu Glu Leu Ile Lys Gly Lys Leu Val Phe Phe Leu Asn Ser Gly 
145                 150                 155                 160 


Asn Ala Lys Leu Pro Ser Thr Ile Ala Pro Val Thr Leu Thr Leu Gly 
                165                 170                 175     


Ser Leu Leu Asp Asp Gln His Trp His Ser Val Leu Ile Glu Leu Leu 
            180                 185                 190         


Asp Thr Gln Val Asn Phe Thr Val Asp Lys His Thr His His Phe Gln 
        195                 200                 205             


Ala Lys Gly Asp Ser Ser Tyr Leu Asp Leu Asn Phe Glu Ile Ser Phe 
    210                 215                 220                 


Gly Gly Ile Pro Thr Pro Gly Arg Ser Arg Ala Phe Arg Arg Lys Ser 
225                 230                 235                 240 


Phe His Gly Cys Leu Glu Asn Leu Tyr Tyr Asn Gly Val Asp Val Thr 
                245                 250                 255     


Glu Leu Ala Lys Lys His Lys Pro Gln Ile Leu Met Met Gly Asn Val 
            260                 265                 270         


Ser Phe Ser Cys Pro Gln Pro Gln Thr Val Pro Val Thr Phe Leu Ser 
        275                 280                 285             


Ser Arg Ser Tyr Leu Ala Leu Pro Gly Asn Ser Gly Glu Asp Lys Val 
    290                 295                 300                 


Ser Val Thr Phe Gln Phe Arg Thr Trp Asn Arg Ala Gly His Leu Leu 
305                 310                 315                 320 


Phe Gly Glu Leu Arg Arg Gly Ser Gly Ser Phe Val Leu Phe Leu Lys 
                325                 330                 335     


Asp Gly Lys Leu Lys Leu Ser Leu Phe Gln Pro Gly Gln Ser Pro Arg 
            340                 345                 350         


Asn Val Thr Ala Gly Ala Gly Leu Asn Asp Gly Gln Trp His Ser Val 
        355                 360                 365             


Ser Phe Ser Ala Lys Trp Ser His Met Asn Val Val Val Asp Asp Asp 
    370                 375                 380                 


Thr Ala Val Gln Pro Leu Val Ala Val Leu Ile Asp Ser Gly Asp Thr 
385                 390                 395                 400 


Tyr Tyr Phe Gly Gly Cys Leu Asp Asn Ser Ser Gly Ser Gly Cys Lys 
                405                 410                 415     


Ser Pro Leu Gly Gly Phe Gln Gly Cys Leu Arg Leu Ile Thr Ile Gly 
            420                 425                 430         


Asp Lys Ala Val Asp Pro Ile Leu Val Gln Gln Gly Ala Leu Gly Ser 
        435                 440                 445             


Phe Arg Asp Leu Gln Ile Asp Ser Cys Gly Ile Thr Asp Arg Cys Leu 
    450                 455                 460                 


Pro Ser Tyr Cys Glu His Gly Gly Glu Cys Ser Gln Ser Trp Asp Thr 
465                 470                 475                 480 


Phe Ser Cys Asp Cys Leu Gly Thr Gly Tyr Thr Gly Glu Thr Cys His 
                485                 490                 495     


Ser Ser Leu Tyr Glu Gln Ser Cys Glu Ala His Lys His Arg Gly Asn 
            500                 505                 510         


Pro Ser Gly Leu Tyr Tyr Ile Asp Ala Asp Gly Ser Gly Pro Leu Gly 
        515                 520                 525             


Pro Phe Leu Val Tyr Cys Asn Met Thr Ala Asp Ala Ala Trp Thr Val 
    530                 535                 540                 


Val Gln His Gly Gly Pro Asp Ala Val Thr Leu Arg Gly Ala Pro Ser 
545                 550                 555                 560 


Gly His Pro Arg Ser Ala Val Ser Phe Ala Tyr Ala Ala Gly Ala Gly 
                565                 570                 575     


Gln Leu Arg Ser Ala Val Asn Leu Ala Glu Arg Cys Glu Gln Arg Leu 
            580                 585                 590         


Ala Leu Arg Cys Gly Thr Ala Arg Arg Pro Asp Ser Arg Asp Gly Thr 
        595                 600                 605             


Pro Leu Ser Trp Trp Val Gly Arg Thr Asn Glu Thr His Thr Ser Trp 
    610                 615                 620                 


Gly Gly Ser Leu Pro Asp Ala Gln Lys Cys Thr Cys Gly Leu Glu Gly 
625                 630                 635                 640 


Asn Cys Ile Asp Ser Gln Tyr Tyr Cys Asn Cys Asp Ala Gly Arg Asn 
                645                 650                 655     


Glu Trp Thr Ser Asp Thr Ile Val Leu Ser Gln Lys Glu His Leu Pro 
            660                 665                 670         


Val Thr Gln Ile Val Met Thr Asp Ala Gly Arg Pro His Ser Glu Ala 
        675                 680                 685             


Ala Tyr Thr Leu Gly Pro Leu Leu Cys Arg Gly Asp Gln Ser Phe Trp 
    690                 695                 700                 


Asn Ser Ala Ser Phe Asn Thr Glu Thr Ser Tyr Leu His Phe Pro Ala 
705                 710                 715                 720 


Phe His Gly Glu Leu Thr Ala Asp Val Cys Phe Phe Phe Lys Thr Thr 
                725                 730                 735     


Val Ser Ser Gly Val Phe Met Glu Asn Leu Gly Ile Thr Asp Phe Ile 
            740                 745                 750         


Arg Ile Glu Leu Arg Ala Pro Thr Glu Val Thr Phe Ser Phe Asp Val 
        755                 760                 765             


Gly Asn Gly Pro Cys Glu Val Thr Val Gln Ser Pro Thr Pro Phe Asn 
    770                 775                 780                 


Asp Asn Gln Trp His His Val Arg Ala Glu Arg Asn Val Lys Gly Ala 
785                 790                 795                 800 


Ser Leu Gln Val Asp Gln Leu Pro Gln Lys Met Gln Pro Ala Pro Ala 
                805                 810                 815     


Asp Gly His Val Arg Leu Gln Leu Asn Ser Gln Leu Phe Ile Gly Gly 
            820                 825                 830         


Thr Ala Thr Arg Gln Arg Gly Phe Leu Gly Cys Ile Arg Ser Leu Gln 
        835                 840                 845             


Leu Asn Gly Val Ala Leu Asp Leu Glu Glu Arg Ala Thr Val Thr Pro 
    850                 855                 860                 


Gly Val Glu Pro Gly Cys Ala Gly His Cys Ser Thr Tyr Gly His Leu 
865                 870                 875                 880 


Cys Arg Asn Gly Gly Arg Cys Arg Glu Lys Arg Arg Gly Val Thr Cys 
                885                 890                 895     


Asp Cys Ala Phe Ser Ala Tyr Asp Gly Pro Phe Cys Ser Asn Glu Ile 
            900                 905                 910         


Ser Ala Tyr Phe Ala Thr Gly Ser Ser Met Thr Tyr His Phe Gln Glu 
        915                 920                 925             


His Tyr Thr Leu Ser Glu Asn Ser Ser Ser Leu Val Ser Ser Leu His 
    930                 935                 940                 


Arg Asp Val Thr Leu Thr Arg Glu Met Ile Thr Leu Ser Phe Arg Thr 
945                 950                 955                 960 


Thr Arg Thr Pro Ser Leu Leu Leu Tyr Val Ser Ser Phe Tyr Glu Glu 
                965                 970                 975     


Tyr Leu Ser Val Ile Leu Ala Asn Asn Gly Ser Leu Gln Ile Arg Tyr 
            980                 985                 990         


Lys Leu Asp Arg His Gln Asn Pro  Asp Ala Phe Thr Phe  Asp Phe Lys 
        995                 1000                 1005             


Asn Met  Ala Asp Gly Gln Leu  His Gln Val Lys Ile  Asn Arg Glu 
    1010                 1015                 1020             


Glu Ala  Val Val Met Val Glu  Val Ile Pro Gln Met  Gln Lys Ser 
    1025                 1030                 1035             


Asn 
    


<210>  3168
<211>  380
<212>  PRT
<213>  Homo Sapiens

<400>  3168

Met Ala Ser Val Ala Trp Ala Val Leu Lys Val Leu Leu Leu Leu Pro 
1               5                   10                  15      


Thr Gln Thr Trp Ser Pro Val Gly Ala Gly Asn Pro Pro Asp Cys Asp 
            20                  25                  30          


Ser Pro Leu Ala Ser Ala Leu Pro Arg Ser Ser Phe Ser Ser Ser Ser 
        35                  40                  45              


Glu Leu Ser Ser Ser His Gly Pro Gly Phe Ser Arg Leu Asn Arg Arg 
    50                  55                  60                  


Asp Gly Ala Gly Gly Trp Thr Pro Leu Val Ser Asn Lys Tyr Gln Trp 
65                  70                  75                  80  


Leu Gln Ile Asp Leu Gly Glu Arg Met Glu Val Thr Ala Val Ala Thr 
                85                  90                  95      


Gln Gly Gly Tyr Gly Ser Ser Asp Trp Val Thr Ser Tyr Leu Leu Met 
            100                 105                 110         


Phe Ser Asp Gly Gly Arg Asn Trp Lys Gln Tyr Arg Arg Glu Glu Ser 
        115                 120                 125             


Ile Trp Gly Phe Pro Gly Asn Thr Asn Ala Asp Ser Val Val His Tyr 
    130                 135                 140                 


Arg Leu Gln Pro Pro Phe Glu Ala Arg Phe Leu Arg Phe Leu Pro Leu 
145                 150                 155                 160 


Ala Trp Asn Pro Arg Gly Arg Ile Gly Met Arg Ile Glu Val Tyr Gly 
                165                 170                 175     


Cys Ala Tyr Lys Ser Glu Val Val Tyr Phe Asp Gly Gln Ser Ala Leu 
            180                 185                 190         


Leu Tyr Thr Leu Asp Lys Lys Pro Leu Lys Pro Ile Arg Asp Val Ile 
        195                 200                 205             


Ser Leu Lys Phe Lys Ala Met Gln Ser Asn Gly Ile Leu Leu His Arg 
    210                 215                 220                 


Glu Gly Gln His Gly Asn His Ile Thr Leu Glu Leu Ile Lys Gly Lys 
225                 230                 235                 240 


Leu Val Phe Phe Leu Asn Ser Gly Asn Ala Lys Leu Pro Ser Thr Ile 
                245                 250                 255     


Ala Pro Val Thr Leu Thr Leu Gly Ser Leu Leu Asp Asp Gln His Trp 
            260                 265                 270         


His Ser Val Leu Ile Glu Leu Leu Asp Thr Gln Val Asn Phe Thr Val 
        275                 280                 285             


Asp Lys His Thr His His Phe Gln Ala Lys Gly Asp Ser Ser Asn Leu 
    290                 295                 300                 


Asp Leu Asn Phe Glu Ile Ser Phe Gly Gly Ile Leu Ser Pro Gly Arg 
305                 310                 315                 320 


Ser Arg Ala Phe Thr Arg Lys Ser Phe His Gly Cys Leu Glu Asn Leu 
                325                 330                 335     


Tyr Tyr Asn Gly Val Asp Val Thr Glu Leu Ala Lys Lys His Lys Pro 
            340                 345                 350         


Gln Ile Leu Met Met Glu Leu Ala His Gly Leu Gln Asp Gln Asn Leu 
        355                 360                 365             


Lys Ile Ser Leu Thr Val Cys His Gln Thr Thr Gln 
    370                 375                 380 


<210>  3169
<211>  745
<212>  PRT
<213>  Homo Sapiens

<400>  3169

Met Ala Ser Val Ala Trp Ala Val Leu Lys Val Leu Leu Leu Leu Pro 
1               5                   10                  15      


Thr Gln Thr Trp Ser Pro Val Gly Ala Gly Asn Pro Pro Asp Cys Asp 
            20                  25                  30          


Ser Pro Leu Ala Ser Ala Leu Pro Arg Ser Ser Phe Ser Ser Ser Ser 
        35                  40                  45              


Glu Leu Ser Ser Ser His Gly Pro Gly Phe Ser Arg Leu Asn Arg Arg 
    50                  55                  60                  


Asp Gly Ala Gly Gly Trp Thr Pro Leu Val Ser Asn Lys Tyr Gln Trp 
65                  70                  75                  80  


Leu Gln Ile Asp Leu Gly Glu Arg Met Glu Val Thr Ala Val Ala Thr 
                85                  90                  95      


Gln Gly Gly Tyr Gly Ser Ser Asp Trp Val Thr Ser Tyr Leu Leu Met 
            100                 105                 110         


Phe Ser Asp Gly Gly Arg Asn Trp Lys Gln Tyr Arg Arg Glu Glu Ser 
        115                 120                 125             


Ile Trp Gly Phe Pro Gly Asn Thr Asn Ala Asp Ser Val Val His Tyr 
    130                 135                 140                 


Arg Leu Gln Pro Pro Phe Glu Ala Arg Phe Leu Arg Phe Leu Pro Leu 
145                 150                 155                 160 


Ala Trp Asn Pro Arg Gly Arg Ile Gly Met Arg Ile Glu Val Tyr Gly 
                165                 170                 175     


Cys Ala Tyr Lys Ser Glu Val Val Tyr Phe Asp Gly Gln Ser Ala Leu 
            180                 185                 190         


Leu Tyr Thr Leu Asp Lys Lys Pro Leu Lys Pro Ile Arg Asp Val Ile 
        195                 200                 205             


Ser Leu Lys Phe Lys Ala Met Gln Ser Asn Gly Ile Leu Leu His Arg 
    210                 215                 220                 


Glu Gly Gln His Gly Asn His Ile Thr Leu Glu Leu Ile Lys Gly Lys 
225                 230                 235                 240 


Leu Val Phe Phe Leu Asn Ser Gly Asn Ala Lys Leu Pro Ser Thr Ile 
                245                 250                 255     


Ala Pro Val Thr Leu Thr Leu Gly Ser Leu Leu Asp Asp Gln His Trp 
            260                 265                 270         


His Ser Val Leu Ile Glu Leu Leu Asp Thr Gln Val Asn Phe Thr Val 
        275                 280                 285             


Asp Lys His Thr His His Phe Gln Ala Lys Gly Asp Ser Ser Asn Leu 
    290                 295                 300                 


Asp Leu Asn Phe Glu Ile Ser Phe Gly Gly Ile Leu Ser Pro Gly Arg 
305                 310                 315                 320 


Ser Arg Ala Phe Thr Arg Lys Ser Phe His Gly Cys Leu Glu Asn Leu 
                325                 330                 335     


Tyr Tyr Asn Gly Val Asp Val Thr Glu Leu Ala Lys Lys His Lys Pro 
            340                 345                 350         


Gln Ile Leu Met Met Gly Asn Val Ser Phe Ser Cys Pro Gln Pro Gln 
        355                 360                 365             


Thr Val Pro Val Thr Phe Leu Ser Ser Arg Ser Tyr Leu Ala Leu Pro 
    370                 375                 380                 


Gly Asn Ser Gly Glu Asp Lys Val Ser Val Thr Phe Gln Phe Arg Thr 
385                 390                 395                 400 


Trp Asn Arg Ala Gly His Leu Leu Phe Gly Glu Leu Gln Arg Gly Ser 
                405                 410                 415     


Gly Ser Phe Val Leu Phe Leu Lys Asp Gly Lys Leu Lys Leu Ser Leu 
            420                 425                 430         


Phe Gln Ala Gly Gln Ser Pro Arg Asn Val Thr Ala Gly Ala Gly Leu 
        435                 440                 445             


Asn Asp Gly Gln Trp His Ser Val Ser Phe Ser Ala Lys Trp Ser His 
    450                 455                 460                 


Met Asn Val Val Val Asp Asp Asp Thr Ala Val Gln Pro Leu Val Ala 
465                 470                 475                 480 


Val Leu Ile Asp Ser Gly Asp Thr Tyr Tyr Phe Gly Gly Cys Leu Gly 
                485                 490                 495     


Asn Ser Ser Gly Ser Gly Cys Lys Ser Pro Leu Gly Gly Phe Gln Gly 
            500                 505                 510         


Cys Leu Arg Leu Ile Thr Ile Gly Asp Lys Ala Val Asp Pro Ile Leu 
        515                 520                 525             


Val Gln Gln Gly Ala Leu Gly Ser Phe Arg Asp Leu Gln Ile Asp Ser 
    530                 535                 540                 


Cys Gly Ile Thr Asp Arg Cys Leu Pro Ser Tyr Cys Glu His Gly Gly 
545                 550                 555                 560 


Glu Cys Ser Gln Ser Trp Asp Thr Phe Ser Cys Asp Cys Leu Gly Thr 
                565                 570                 575     


Gly Tyr Thr Gly Glu Thr Cys His Ser Ser Leu Tyr Glu Gln Ser Cys 
            580                 585                 590         


Glu Ala His Lys His Arg Gly Asn Pro Ser Gly Leu Tyr Tyr Ile Asp 
        595                 600                 605             


Ala Asp Gly Ser Gly Pro Leu Gly Pro Phe Leu Val Tyr Cys Asn Met 
    610                 615                 620                 


Thr Asp Ser Ala Trp Thr Val Val Arg His Gly Gly Pro Asp Ala Val 
625                 630                 635                 640 


Thr Leu Arg Gly Ala Pro Ser Gly His Pro Leu Ser Ala Val Ser Phe 
                645                 650                 655     


Ala Tyr Ala Ala Gly Ala Gly Gln Leu Arg Ala Ala Val Asn Leu Ala 
            660                 665                 670         


Glu Arg Cys Glu Gln Arg Leu Ala Leu Arg Cys Gly Thr Ala Arg Arg 
        675                 680                 685             


Pro Asp Ser Arg Asp Gly Thr Pro Leu Ser Trp Trp Val Gly Arg Thr 
    690                 695                 700                 


Asn Glu Thr His Thr Ser Trp Gly Gly Ser Leu Pro Asp Ala Gln Lys 
705                 710                 715                 720 


Cys Thr Cys Gly Leu Glu Gly Asn Cys Ile Asp Ser Gln Tyr Tyr Cys 
                725                 730                 735     


Asn Cys Asp Ala Gly Gln Asn Glu Trp 
            740                 745 


<210>  3170
<211>  1288
<212>  PRT
<213>  Homo Sapiens

<400>  3170

Met Ala Ser Val Ala Trp Ala Val Leu Lys Val Leu Leu Leu Leu Pro 
1               5                   10                  15      


Thr Gln Thr Trp Ser Pro Val Gly Ala Gly Asn Pro Pro Asp Cys Asp 
            20                  25                  30          


Ser Pro Leu Ala Ser Ala Leu Pro Arg Ser Ser Phe Ser Ser Ser Ser 
        35                  40                  45              


Glu Leu Ser Ser Ser His Gly Pro Gly Phe Ser Arg Leu Asn Arg Arg 
    50                  55                  60                  


Asp Gly Ala Gly Gly Trp Thr Pro Leu Val Ser Asn Lys Tyr Gln Trp 
65                  70                  75                  80  


Leu Gln Ile Asp Leu Gly Glu Arg Met Glu Val Thr Ala Val Ala Thr 
                85                  90                  95      


Gln Gly Gly Tyr Gly Ser Ser Asp Trp Val Thr Ser Tyr Leu Leu Met 
            100                 105                 110         


Phe Ser Asp Gly Gly Arg Asn Trp Lys Gln Tyr Arg Arg Glu Glu Ser 
        115                 120                 125             


Ile Trp Gly Phe Pro Gly Asn Thr Asn Ala Asp Ser Val Val His Tyr 
    130                 135                 140                 


Arg Leu Gln Pro Pro Phe Glu Ala Arg Phe Leu Arg Phe Leu Pro Leu 
145                 150                 155                 160 


Ala Trp Asn Pro Arg Gly Arg Ile Gly Met Arg Ile Glu Val Tyr Gly 
                165                 170                 175     


Cys Ala Tyr Lys Ser Glu Val Val Tyr Phe Asp Gly Gln Ser Ala Leu 
            180                 185                 190         


Leu Tyr Thr Leu Asp Lys Lys Pro Leu Lys Pro Ile Arg Asp Val Ile 
        195                 200                 205             


Ser Leu Lys Phe Lys Ala Met Gln Ser Asn Gly Ile Leu Leu His Arg 
    210                 215                 220                 


Glu Gly Gln His Gly Asn His Ile Thr Leu Glu Leu Ile Lys Gly Lys 
225                 230                 235                 240 


Leu Val Phe Phe Leu Asn Ser Gly Asn Ala Lys Leu Pro Ser Thr Ile 
                245                 250                 255     


Ala Pro Val Thr Leu Thr Leu Gly Ser Leu Leu Asp Asp Gln His Trp 
            260                 265                 270         


His Ser Val Leu Ile Glu Leu Leu Asp Thr Gln Val Asn Phe Thr Val 
        275                 280                 285             


Asp Lys His Thr His His Phe Gln Ala Lys Gly Asp Ser Ser Asn Leu 
    290                 295                 300                 


Asp Leu Asn Phe Glu Ile Ser Phe Gly Gly Ile Leu Ser Pro Gly Arg 
305                 310                 315                 320 


Ser Arg Ala Phe Thr Arg Lys Ser Phe His Gly Cys Leu Glu Asn Leu 
                325                 330                 335     


Tyr Tyr Asn Gly Val Asp Val Thr Glu Leu Ala Lys Lys His Lys Pro 
            340                 345                 350         


Gln Ile Leu Met Met Gly Asn Val Ser Phe Ser Cys Pro Gln Pro Gln 
        355                 360                 365             


Thr Val Pro Val Thr Phe Leu Ser Ser Arg Ser Tyr Leu Ala Leu Pro 
    370                 375                 380                 


Gly Asn Ser Gly Glu Asp Lys Val Ser Val Thr Phe Gln Phe Arg Thr 
385                 390                 395                 400 


Trp Asn Arg Ala Gly His Leu Leu Phe Gly Glu Leu Gln Arg Gly Ser 
                405                 410                 415     


Gly Ser Phe Val Leu Phe Leu Lys Asp Gly Lys Leu Lys Leu Ser Leu 
            420                 425                 430         


Phe Gln Ala Gly Gln Ser Pro Arg Asn Val Thr Ala Gly Ala Gly Leu 
        435                 440                 445             


Asn Asp Gly Gln Trp His Ser Val Ser Phe Ser Ala Lys Trp Ser His 
    450                 455                 460                 


Met Asn Val Val Val Asp Asp Asp Thr Ala Val Gln Pro Leu Val Ala 
465                 470                 475                 480 


Val Leu Ile Asp Ser Gly Asp Thr Tyr Tyr Phe Gly Gly Cys Leu Gly 
                485                 490                 495     


Asn Ser Ser Gly Ser Gly Cys Lys Ser Pro Leu Gly Gly Phe Gln Gly 
            500                 505                 510         


Cys Leu Arg Leu Ile Thr Ile Gly Asp Lys Ala Val Asp Pro Ile Leu 
        515                 520                 525             


Val Gln Gln Gly Ala Leu Gly Ser Phe Arg Asp Leu Gln Ile Asp Ser 
    530                 535                 540                 


Cys Gly Ile Thr Asp Arg Cys Leu Pro Ser Tyr Cys Glu His Gly Gly 
545                 550                 555                 560 


Glu Cys Ser Gln Ser Trp Asp Thr Phe Ser Cys Asp Cys Leu Gly Thr 
                565                 570                 575     


Gly Tyr Thr Gly Glu Thr Cys His Ser Ser Leu Tyr Glu Gln Ser Cys 
            580                 585                 590         


Glu Ala His Lys His Arg Gly Asn Pro Ser Gly Leu Tyr Tyr Ile Asp 
        595                 600                 605             


Ala Asp Gly Ser Gly Pro Leu Gly Pro Phe Leu Val Tyr Cys Asn Met 
    610                 615                 620                 


Thr Ala Asp Ser Ala Trp Thr Val Val Arg His Gly Gly Pro Asp Ala 
625                 630                 635                 640 


Val Thr Leu Arg Gly Ala Pro Ser Gly His Pro Leu Ser Ala Val Ser 
                645                 650                 655     


Phe Ala Tyr Ala Ala Gly Ala Gly Gln Leu Arg Ala Ala Val Asn Leu 
            660                 665                 670         


Ala Glu Arg Cys Glu Gln Arg Leu Ala Leu Arg Cys Gly Thr Ala Arg 
        675                 680                 685             


Arg Pro Asp Ser Arg Asp Gly Thr Pro Leu Ser Trp Trp Val Gly Arg 
    690                 695                 700                 


Thr Asn Glu Thr His Thr Ser Trp Gly Gly Ser Leu Pro Asp Ala Gln 
705                 710                 715                 720 


Lys Cys Thr Cys Gly Leu Glu Gly Asn Cys Ile Asp Ser Gln Tyr Tyr 
                725                 730                 735     


Cys Asn Cys Asp Ala Gly Gln Asn Glu Trp Thr Ser Asp Thr Ile Val 
            740                 745                 750         


Leu Ser Gln Lys Glu His Leu Pro Val Thr Gln Ile Val Met Thr Asp 
        755                 760                 765             


Thr Gly Gln Pro His Ser Glu Ala Asp Tyr Thr Leu Gly Pro Leu Leu 
    770                 775                 780                 


Cys Arg Gly Asp Lys Ser Phe Trp Asn Ser Ala Ser Phe Asn Thr Glu 
785                 790                 795                 800 


Thr Ser Tyr Leu His Phe Pro Ala Phe His Gly Glu Leu Thr Ala Asp 
                805                 810                 815     


Val Cys Phe Phe Phe Lys Thr Thr Val Ser Ser Gly Val Phe Met Glu 
            820                 825                 830         


Asn Leu Gly Ile Thr Asp Phe Ile Arg Ile Glu Leu Arg Ala Pro Thr 
        835                 840                 845             


Glu Val Thr Phe Ser Phe Asp Val Gly Asn Gly Pro Cys Glu Val Thr 
    850                 855                 860                 


Val Gln Ser Pro Thr Pro Phe Asn Asp Asn Gln Trp His His Val Arg 
865                 870                 875                 880 


Ala Glu Arg Asn Val Lys Gly Ala Ser Leu Gln Val Asp Gln Leu Pro 
                885                 890                 895     


Gln Lys Met Gln Pro Ala Pro Ala Asp Gly His Val Arg Leu Gln Leu 
            900                 905                 910         


Asn Ser Gln Leu Phe Ile Gly Gly Thr Ala Thr Arg Gln Arg Gly Phe 
        915                 920                 925             


Leu Gly Cys Ile Arg Ser Leu Gln Leu Asn Gly Val Ala Leu Asp Leu 
    930                 935                 940                 


Glu Glu Arg Ala Thr Val Thr Pro Gly Val Glu Pro Gly Cys Ala Gly 
945                 950                 955                 960 


His Cys Ser Thr Tyr Gly His Leu Cys Arg Asn Gly Gly Arg Cys Arg 
                965                 970                 975     


Glu Lys Arg Arg Gly Val Thr Cys Asp Cys Ala Phe Ser Ala Tyr Asp 
            980                 985                 990         


Gly Pro Phe Cys Ser Asn Glu Ile  Ser Ala Tyr Phe Ala  Thr Gly Ser 
        995                 1000                 1005             


Ser Met  Thr Tyr His Phe Gln  Glu His Tyr Thr Leu  Ser Glu Asn 
    1010                 1015                 1020             


Ser Ser  Ser Leu Val Ser Ser  Leu His Arg Asp Val  Thr Leu Thr 
    1025                 1030                 1035             


Arg Glu  Met Ile Thr Leu Ser  Phe Arg Thr Thr Arg  Thr Pro Ser 
    1040                 1045                 1050             


Leu Leu  Leu Tyr Val Ser Ser  Phe Tyr Glu Glu Tyr  Leu Ser Val 
    1055                 1060                 1065             


Ile Leu  Ala Asn Asn Gly Ser  Leu Gln Ile Arg Tyr  Lys Leu Asp 
    1070                 1075                 1080             


Arg His  Gln Asn Pro Asp Ala  Phe Thr Phe Asp Phe  Lys Asn Met 
    1085                 1090                 1095             


Ala Asp  Gly Gln Leu His Gln  Val Lys Ile Asn Arg  Glu Glu Ala 
    1100                 1105                 1110             


Val Val  Met Val Glu Val Asn  Gln Ser Ala Lys Lys  Gln Val Ile 
    1115                 1120                 1125             


Leu Ser  Ser Gly Thr Glu Phe  Asn Ala Val Lys Ser  Leu Ile Leu 
    1130                 1135                 1140             


Gly Lys  Val Leu Glu Ala Ala  Gly Ala Asp Pro Asp  Thr Arg Arg 
    1145                 1150                 1155             


Ala Ala  Thr Ser Gly Phe Thr  Gly Cys Leu Ser Ala  Val Arg Phe 
    1160                 1165                 1170             


Gly Cys  Ala Ala Pro Leu Lys  Ala Ala Leu Arg Pro  Ser Gly Pro 
    1175                 1180                 1185             


Ser Arg  Val Thr Val Arg Gly  His Val Ala Pro Met  Ala Arg Cys 
    1190                 1195                 1200             


Ala Ala  Gly Ala Ala Ser Gly  Ser Pro Ala Arg Glu  Leu Ala Pro 
    1205                 1210                 1215             


Arg Leu  Ala Gly Gly Ala Gly  Arg Ser Gly Pro Val  Asp Glu Gly 
    1220                 1225                 1230             


Glu Pro  Leu Val Asn Ala Asp  Arg Arg Asp Ser Ala  Val Ile Gly 
    1235                 1240                 1245             


Gly Val  Ile Ala Val Glu Ile  Phe Ile Leu Leu Cys  Ile Thr Ala 
    1250                 1255                 1260             


Ile Ala  Ile Arg Ile Tyr Gln  Gln Arg Lys Leu Arg  Lys Glu Asn 
    1265                 1270                 1275             


Glu Ser  Lys Val Ser Lys Lys  Glu Glu Cys 
    1280                 1285             


<210>  3171
<211>  605
<212>  PRT
<213>  Homo Sapiens

<400>  3171

Met Ala Ser Val Ala Trp Ala Val Leu Lys Val Leu Leu Leu Leu Pro 
1               5                   10                  15      


Thr Gln Thr Trp Ser Pro Val Gly Ala Gly Asn Pro Pro Asp Cys Asp 
            20                  25                  30          


Ser Pro Leu Ala Ser Ala Leu Pro Arg Ser Ser Phe Ser Ser Ser Ser 
        35                  40                  45              


Glu Leu Ser Ser Ser His Gly Pro Gly Phe Ser Arg Leu Asn Arg Arg 
    50                  55                  60                  


Asp Gly Ala Gly Gly Trp Thr Pro Leu Val Ser Asn Lys Tyr Gln Trp 
65                  70                  75                  80  


Leu Gln Ile Asp Leu Gly Glu Arg Met Glu Val Thr Ala Val Ala Thr 
                85                  90                  95      


Gln Gly Gly Tyr Gly Ser Ser Asp Trp Val Thr Ser Tyr Leu Leu Met 
            100                 105                 110         


Phe Ser Asp Gly Gly Arg Asn Trp Lys Gln Tyr Arg Arg Glu Glu Ser 
        115                 120                 125             


Ile Trp Gly Phe Pro Gly Asn Thr Asn Ala Asp Ser Val Val His Tyr 
    130                 135                 140                 


Arg Leu Gln Pro Pro Phe Glu Ala Arg Phe Leu Arg Phe Leu Pro Leu 
145                 150                 155                 160 


Ala Trp Asn Pro Arg Gly Arg Ile Gly Met Arg Ile Glu Val Tyr Gly 
                165                 170                 175     


Cys Ala Tyr Lys Ser Glu Val Val Tyr Phe Asp Gly Gln Ser Ala Leu 
            180                 185                 190         


Leu Tyr Thr Leu Asp Lys Lys Pro Leu Lys Pro Ile Arg Asp Val Ile 
        195                 200                 205             


Ser Leu Lys Phe Lys Ala Met Gln Ser Asn Gly Ile Leu Leu His Arg 
    210                 215                 220                 


Glu Gly Gln His Gly Asn His Ile Thr Leu Glu Leu Ile Lys Gly Lys 
225                 230                 235                 240 


Leu Val Phe Phe Leu Asn Ser Gly Asn Ala Lys Leu Pro Ser Thr Ile 
                245                 250                 255     


Ala Pro Val Thr Leu Thr Leu Gly Ser Leu Leu Asp Asp Gln His Trp 
            260                 265                 270         


His Ser Val Leu Ile Glu Leu Leu Asp Thr Gln Val Asn Phe Thr Val 
        275                 280                 285             


Asp Lys His Thr His His Phe Gln Ala Lys Gly Asp Ser Ser Asn Leu 
    290                 295                 300                 


Asp Leu Asn Phe Glu Ile Ser Phe Gly Gly Ile Leu Ser Pro Gly Arg 
305                 310                 315                 320 


Ser Arg Ala Phe Thr Arg Lys Ser Phe His Gly Cys Leu Glu Asn Leu 
                325                 330                 335     


Tyr Tyr Asn Gly Val Asp Val Thr Glu Leu Ala Lys Lys His Lys Pro 
            340                 345                 350         


Gln Ile Leu Met Met Gly Asn Val Ser Phe Ser Cys Pro Gln Pro Gln 
        355                 360                 365             


Thr Val Pro Val Thr Phe Leu Ser Ser Arg Ser Tyr Leu Ala Leu Pro 
    370                 375                 380                 


Gly Asn Ser Gly Glu Asp Lys Val Ser Val Thr Phe Gln Phe Arg Thr 
385                 390                 395                 400 


Trp Asn Arg Ala Gly His Leu Leu Phe Gly Glu Leu Gln Arg Gly Ser 
                405                 410                 415     


Gly Ser Phe Val Leu Phe Leu Lys Asp Gly Lys Leu Lys Leu Ser Leu 
            420                 425                 430         


Phe Gln Ala Gly Gln Ser Pro Arg Asn Val Thr Ala Gly Ala Gly Leu 
        435                 440                 445             


Asn Asp Gly Gln Trp His Ser Val Ser Phe Ser Ala Lys Trp Ser His 
    450                 455                 460                 


Met Asn Val Val Val Asp Asp Asp Thr Ala Val Gln Pro Leu Val Ala 
465                 470                 475                 480 


Val Leu Ile Asp Ser Gly Asp Thr Tyr Tyr Phe Gly Ala Leu Tyr Glu 
                485                 490                 495     


Gln Ser Cys Glu Ala His Lys His Arg Gly Asn Pro Ser Gly Leu Tyr 
            500                 505                 510         


Tyr Ile Asp Ala Asp Gly Ser Gly Pro Leu Gly Pro Phe Leu Val Tyr 
        515                 520                 525             


Cys Asn Met Thr Ala Asp Ser Ala Trp Thr Val Val Arg His Gly Gly 
    530                 535                 540                 


Pro Asp Ala Val Thr Leu Arg Gly Ala Pro Ser Gly His Pro Leu Ser 
545                 550                 555                 560 


Ala Val Ser Phe Ala Tyr Ala Ala Gly Ala Gly Gln Leu Arg Ala Ala 
                565                 570                 575     


Val Asn Leu Ala Glu Arg Cys Glu Gln Arg Leu Ala Leu Arg Cys Gly 
            580                 585                 590         


Thr Ala Arg Arg Pro Asp Ser Arg Gly Leu Val Thr Gln 
        595                 600                 605 


<210>  3172
<211>  1207
<212>  PRT
<213>  Homo Sapiens

<400>  3172

Met Ala Ser Val Ala Trp Ala Val Leu Lys Val Leu Leu Leu Leu Pro 
1               5                   10                  15      


Thr Gln Thr Trp Ser Pro Val Gly Ala Gly Asn Pro Pro Asp Cys Asp 
            20                  25                  30          


Ser Pro Leu Ala Ser Ala Leu Pro Arg Ser Ser Phe Ser Ser Ser Ser 
        35                  40                  45              


Glu Leu Ser Ser Ser His Gly Pro Gly Phe Ser Arg Leu Asn Arg Arg 
    50                  55                  60                  


Asp Gly Ala Gly Gly Trp Thr Pro Leu Val Ser Asn Lys Tyr Gln Trp 
65                  70                  75                  80  


Leu Gln Ile Asp Leu Gly Glu Arg Met Glu Val Thr Ala Val Ala Thr 
                85                  90                  95      


Gln Gly Gly Tyr Gly Ser Ser Asp Trp Val Thr Ser Tyr Leu Leu Met 
            100                 105                 110         


Phe Ser Asp Gly Gly Arg Asn Trp Lys Gln Tyr Arg Arg Glu Glu Ser 
        115                 120                 125             


Ile Trp Gly Phe Pro Gly Asn Thr Asn Ala Asp Ser Val Val His Tyr 
    130                 135                 140                 


Arg Leu Gln Pro Pro Phe Glu Ala Arg Phe Leu Arg Phe Leu Pro Leu 
145                 150                 155                 160 


Ala Trp Asn Pro Arg Gly Arg Ile Gly Met Arg Ile Glu Val Tyr Gly 
                165                 170                 175     


Cys Ala Tyr Lys Ser Glu Val Val Tyr Phe Asp Gly Gln Ser Ala Leu 
            180                 185                 190         


Leu Tyr Thr Leu Asp Lys Lys Pro Leu Lys Pro Ile Arg Asp Val Ile 
        195                 200                 205             


Ser Leu Lys Phe Lys Ala Met Gln Ser Asn Gly Ile Leu Leu His Arg 
    210                 215                 220                 


Glu Gly Gln His Gly Asn His Ile Thr Leu Glu Leu Ile Lys Gly Lys 
225                 230                 235                 240 


Leu Val Phe Phe Leu Asn Ser Gly Asn Ala Lys Leu Pro Ser Thr Ile 
                245                 250                 255     


Ala Pro Val Thr Leu Thr Leu Gly Ser Leu Leu Asp Asp Gln His Trp 
            260                 265                 270         


His Ser Val Leu Ile Glu Leu Leu Asp Thr Gln Val Asn Phe Thr Val 
        275                 280                 285             


Asp Lys His Thr His His Phe Gln Ala Lys Gly Asp Ser Ser Asn Leu 
    290                 295                 300                 


Asp Leu Asn Phe Glu Ile Ser Phe Gly Gly Ile Leu Ser Pro Gly Arg 
305                 310                 315                 320 


Ser Arg Ala Phe Thr Arg Lys Ser Phe His Gly Cys Leu Glu Asn Leu 
                325                 330                 335     


Tyr Tyr Asn Gly Val Asp Val Thr Glu Leu Ala Lys Lys His Lys Pro 
            340                 345                 350         


Gln Ile Leu Met Met Gly Asn Val Ser Phe Ser Cys Pro Gln Pro Gln 
        355                 360                 365             


Thr Val Pro Val Thr Phe Leu Ser Ser Arg Ser Tyr Leu Ala Leu Pro 
    370                 375                 380                 


Gly Asn Ser Gly Glu Asp Lys Val Ser Val Thr Phe Gln Phe Arg Thr 
385                 390                 395                 400 


Trp Asn Arg Ala Gly His Leu Leu Phe Gly Glu Leu Gln Arg Gly Ser 
                405                 410                 415     


Gly Ser Phe Val Leu Phe Leu Lys Asp Gly Lys Leu Lys Leu Ser Leu 
            420                 425                 430         


Phe Gln Ala Gly Gln Ser Pro Arg Asn Val Thr Ala Gly Ala Gly Leu 
        435                 440                 445             


Asn Asp Gly Gln Trp His Ser Val Ser Phe Ser Ala Lys Trp Ser His 
    450                 455                 460                 


Met Asn Val Val Val Asp Asp Asp Thr Ala Val Gln Pro Leu Val Ala 
465                 470                 475                 480 


Val Leu Ile Asp Ser Gly Asp Thr Tyr Tyr Phe Gly Gly Cys Leu Gly 
                485                 490                 495     


Asn Ser Ser Gly Ser Gly Cys Lys Ser Pro Leu Gly Gly Phe Gln Gly 
            500                 505                 510         


Cys Leu Arg Leu Ile Thr Ile Gly Asp Lys Ala Val Asp Pro Ile Leu 
        515                 520                 525             


Val Gln Gln Gly Ala Leu Gly Ser Phe Arg Asp Leu Gln Ile Asp Ser 
    530                 535                 540                 


Cys Gly Ile Thr Asp Arg Cys Leu Pro Ser Tyr Cys Glu His Gly Gly 
545                 550                 555                 560 


Glu Cys Ser Gln Ser Trp Asp Thr Phe Ser Cys Asp Cys Leu Gly Thr 
                565                 570                 575     


Gly Tyr Thr Gly Glu Thr Cys His Ser Ser Leu Tyr Glu Gln Ser Cys 
            580                 585                 590         


Glu Ala His Lys His Arg Gly Asn Pro Ser Gly Leu Tyr Tyr Ile Asp 
        595                 600                 605             


Ala Asp Gly Ser Gly Pro Leu Gly Pro Phe Leu Val Tyr Cys Asn Met 
    610                 615                 620                 


Thr Asp Ser Ala Trp Thr Val Val Arg His Gly Gly Pro Asp Ala Val 
625                 630                 635                 640 


Thr Leu Arg Gly Ala Pro Ser Gly His Pro Leu Ser Ala Val Ser Phe 
                645                 650                 655     


Ala Tyr Ala Ala Gly Ala Gly Gln Leu Arg Ala Ala Val Asn Leu Ala 
            660                 665                 670         


Glu Arg Cys Glu Gln Arg Leu Ala Leu Arg Cys Gly Thr Ala Arg Arg 
        675                 680                 685             


Pro Asp Ser Arg Asp Gly Thr Pro Leu Ser Trp Trp Val Gly Arg Thr 
    690                 695                 700                 


Asn Glu Thr His Thr Ser Trp Gly Gly Ser Leu Pro Asp Ala Gln Lys 
705                 710                 715                 720 


Cys Thr Cys Gly Leu Glu Gly Asn Cys Ile Asp Ser Gln Tyr Tyr Cys 
                725                 730                 735     


Asn Cys Asp Ala Gly Gln Asn Glu Trp Thr Ser Asp Thr Ile Val Leu 
            740                 745                 750         


Ser Gln Lys Glu His Leu Pro Val Thr Gln Ile Val Met Thr Asp Thr 
        755                 760                 765             


Gly Gln Pro His Ser Glu Ala Asp Tyr Thr Leu Gly Pro Leu Leu Cys 
    770                 775                 780                 


Arg Gly Asp Lys Ser Phe Trp Asn Ser Ala Ser Phe Asn Thr Glu Thr 
785                 790                 795                 800 


Ser Tyr Leu His Phe Pro Ala Phe His Gly Glu Leu Thr Ala Asp Val 
                805                 810                 815     


Cys Phe Phe Phe Lys Thr Thr Val Ser Ser Gly Val Phe Met Glu Asn 
            820                 825                 830         


Leu Gly Ile Thr Asp Phe Ile Arg Ile Glu Leu Arg Ala Pro Thr Glu 
        835                 840                 845             


Val Thr Phe Ser Phe Asp Val Gly Asn Gly Pro Cys Glu Val Thr Val 
    850                 855                 860                 


Gln Ser Pro Thr Pro Phe Asn Asp Asn Gln Trp His His Val Arg Ala 
865                 870                 875                 880 


Glu Arg Asn Val Lys Gly Ala Ser Leu Gln Val Asp Gln Leu Pro Gln 
                885                 890                 895     


Lys Met Gln Pro Ala Pro Ala Asp Gly His Val Arg Leu Gln Leu Asn 
            900                 905                 910         


Ser Gln Leu Phe Ile Glu Ile Ser Ala Tyr Phe Ala Thr Gly Ser Ser 
        915                 920                 925             


Met Thr Tyr His Phe Gln Glu His Tyr Thr Leu Ser Glu Asn Ser Ser 
    930                 935                 940                 


Ser Leu Val Ser Ser Leu His Arg Asp Val Thr Leu Thr Arg Glu Met 
945                 950                 955                 960 


Ile Thr Leu Ser Phe Arg Thr Thr Arg Thr Pro Ser Leu Leu Leu Tyr 
                965                 970                 975     


Val Ser Ser Phe Tyr Glu Glu Tyr Leu Ser Val Ile Leu Ala Asn Asn 
            980                 985                 990         


Gly Ser Leu Gln Ile Arg Tyr Lys  Leu Asp Arg His Gln  Asn Pro Asp 
        995                 1000                 1005             


Ala Phe  Thr Phe Asp Phe Lys  Asn Met Ala Asp Gly  Gln Leu His 
    1010                 1015                 1020             


Gln Val  Lys Ile Asn Arg Glu  Glu Ala Val Val Met  Val Glu Val 
    1025                 1030                 1035             


Asn Gln  Ser Ala Lys Lys Gln  Val Ile Leu Ser Ser  Gly Thr Glu 
    1040                 1045                 1050             


Phe Asn  Ala Val Lys Ser Leu  Ile Leu Gly Lys Val  Leu Glu Ala 
    1055                 1060                 1065             


Ala Gly  Ala Asp Pro Asp Thr  Arg Arg Ala Ala Thr  Ser Gly Phe 
    1070                 1075                 1080             


Thr Gly  Cys Leu Ser Ala Val  Arg Phe Gly Cys Ala  Ala Pro Leu 
    1085                 1090                 1095             


Lys Ala  Ala Leu Arg Pro Ser  Gly Pro Ser Arg Val  Thr Val Arg 
    1100                 1105                 1110             


Gly His  Val Ala Pro Met Ala  Arg Cys Ala Ala Gly  Ala Ala Ser 
    1115                 1120                 1125             


Gly Ser  Pro Ala Arg Glu Leu  Ala Pro Arg Leu Ala  Gly Gly Ala 
    1130                 1135                 1140             


Gly Arg  Ser Gly Pro Val Asp  Glu Gly Glu Pro Leu  Val Asn Ala 
    1145                 1150                 1155             


Asp Arg  Arg Asp Ser Ala Val  Ile Gly Gly Val Ile  Ala Val Glu 
    1160                 1165                 1170             


Ile Phe  Ile Leu Leu Cys Ile  Thr Ala Ile Ala Ile  Arg Ile Tyr 
    1175                 1180                 1185             


Gln Gln  Arg Lys Leu Arg Lys  Glu Asn Glu Ser Lys  Val Ser Lys 
    1190                 1195                 1200             


Lys Glu  Glu Cys 
    1205         


<210>  3173
<211>  652
<212>  PRT
<213>  Homo Sapiens

<400>  3173

Met Ala Ser Val Ala Trp Ala Val Leu Lys Val Leu Leu Leu Leu Pro 
1               5                   10                  15      


Thr Gln Thr Trp Ser Pro Val Gly Ala Gly Asn Pro Pro Asp Cys Asp 
            20                  25                  30          


Ser Pro Leu Ala Ser Ala Leu Pro Arg Ser Ser Phe Ser Ser Ser Ser 
        35                  40                  45              


Glu Leu Ser Ser Ser His Gly Pro Gly Phe Ser Arg Leu Asn Arg Arg 
    50                  55                  60                  


Asp Gly Ala Gly Gly Trp Thr Pro Leu Val Ser Asn Lys Tyr Gln Trp 
65                  70                  75                  80  


Leu Gln Ile Asp Leu Gly Glu Arg Met Glu Val Thr Ala Val Ala Thr 
                85                  90                  95      


Gln Gly Gly Tyr Gly Ser Ser Asp Trp Val Thr Ser Tyr Leu Leu Met 
            100                 105                 110         


Phe Ser Asp Gly Gly Arg Asn Trp Lys Gln Tyr Arg Arg Glu Glu Ser 
        115                 120                 125             


Ile Trp Gly Phe Pro Gly Asn Thr Asn Ala Asp Ser Val Val His Tyr 
    130                 135                 140                 


Arg Leu Gln Pro Pro Phe Glu Ala Arg Phe Leu Arg Phe Leu Pro Leu 
145                 150                 155                 160 


Ala Trp Asn Pro Arg Gly Arg Ile Gly Met Arg Ile Glu Val Tyr Gly 
                165                 170                 175     


Cys Ala Tyr Lys Ser Glu Val Val Tyr Phe Asp Gly Gln Ser Ala Leu 
            180                 185                 190         


Leu Tyr Thr Leu Asp Lys Lys Pro Leu Lys Pro Ile Arg Asp Val Ile 
        195                 200                 205             


Ser Leu Lys Phe Lys Ala Met Gln Ser Asn Gly Ile Leu Leu His Arg 
    210                 215                 220                 


Glu Gly Gln His Gly Asn His Ile Thr Leu Glu Leu Ile Lys Gly Lys 
225                 230                 235                 240 


Leu Val Phe Phe Leu Asn Ser Gly Asn Ala Lys Leu Pro Ser Thr Ile 
                245                 250                 255     


Ala Pro Val Thr Leu Thr Leu Gly Ser Leu Leu Asp Asp Gln His Trp 
            260                 265                 270         


His Ser Val Leu Ile Glu Leu Leu Asp Thr Gln Val Asn Phe Thr Val 
        275                 280                 285             


Asp Lys His Thr His His Phe Gln Ala Lys Gly Asp Ser Ser Asn Leu 
    290                 295                 300                 


Asp Leu Asn Phe Glu Ile Ser Phe Gly Gly Ile Leu Ser Pro Gly Arg 
305                 310                 315                 320 


Ser Arg Ala Phe Thr Arg Lys Ser Phe His Gly Cys Leu Glu Asn Leu 
                325                 330                 335     


Tyr Tyr Asn Gly Val Asp Val Thr Glu Leu Ala Lys Lys His Lys Pro 
            340                 345                 350         


Gln Ile Leu Met Met Gly Asn Val Ser Phe Ser Cys Pro Gln Pro Gln 
        355                 360                 365             


Thr Val Pro Val Thr Phe Leu Ser Ser Arg Ser Tyr Leu Ala Leu Pro 
    370                 375                 380                 


Gly Asn Ser Gly Glu Asp Lys Val Ser Val Thr Phe Gln Phe Arg Thr 
385                 390                 395                 400 


Trp Asn Arg Ala Gly His Leu Leu Phe Gly Glu Leu Gln Arg Gly Ser 
                405                 410                 415     


Gly Ser Phe Val Leu Phe Leu Lys Asp Gly Lys Leu Lys Leu Ser Leu 
            420                 425                 430         


Phe Gln Ala Gly Gln Ser Pro Arg Asn Val Thr Ala Gly Ala Gly Leu 
        435                 440                 445             


Asn Asp Gly Gln Trp His Ser Val Ser Phe Ser Ala Lys Trp Ser His 
    450                 455                 460                 


Met Asn Val Val Val Asp Asp Asp Thr Ala Val Gln Pro Leu Val Ala 
465                 470                 475                 480 


Val Leu Ile Asp Ser Gly Asp Thr Tyr Tyr Phe Gly Ala Leu Tyr Glu 
                485                 490                 495     


Gln Ser Cys Glu Ala His Lys His Arg Gly Asn Pro Ser Gly Leu Tyr 
            500                 505                 510         


Tyr Ile Asp Ala Asp Gly Ser Gly Pro Leu Gly Pro Phe Leu Val Tyr 
        515                 520                 525             


Cys Asn Met Thr Asp Ser Ala Trp Thr Val Val Arg His Gly Gly Pro 
    530                 535                 540                 


Asp Ala Val Thr Leu Arg Gly Ala Pro Ser Gly His Pro Leu Ser Ala 
545                 550                 555                 560 


Val Ser Phe Ala Tyr Ala Ala Gly Ala Gly Gln Leu Arg Ala Ala Val 
                565                 570                 575     


Asn Leu Ala Glu Arg Cys Glu Gln Arg Leu Ala Leu Arg Cys Gly Thr 
            580                 585                 590         


Ala Arg Arg Pro Asp Ser Arg Asp Gly Thr Pro Leu Ser Trp Trp Val 
        595                 600                 605             


Gly Arg Thr Asn Glu Thr His Thr Ser Trp Gly Gly Ser Leu Pro Asp 
    610                 615                 620                 


Ala Gln Lys Cys Thr Cys Gly Leu Glu Gly Asn Cys Ile Asp Ser Gln 
625                 630                 635                 640 


Tyr Tyr Cys Asn Cys Asp Ala Gly Gln Asn Glu Trp 
                645                 650         


<210>  3174
<211>  966
<212>  PRT
<213>  Homo Sapiens

<400>  3174

Met Ala Ser Val Ala Trp Ala Val Leu Lys Val Leu Leu Leu Leu Pro 
1               5                   10                  15      


Thr Gln Thr Trp Ser Pro Val Gly Ala Gly Asn Pro Pro Asp Cys Asp 
            20                  25                  30          


Ser Pro Leu Ala Ser Ala Leu Pro Arg Ser Ser Phe Ser Ser Ser Ser 
        35                  40                  45              


Glu Leu Ser Ser Ser His Gly Pro Gly Phe Ser Arg Leu Asn Arg Arg 
    50                  55                  60                  


Asp Gly Ala Gly Gly Trp Thr Pro Leu Val Ser Asn Lys Tyr Gln Trp 
65                  70                  75                  80  


Leu Gln Ile Asp Leu Gly Glu Arg Met Glu Val Thr Ala Val Ala Thr 
                85                  90                  95      


Gln Gly Gly Tyr Gly Ser Ser Asp Trp Val Thr Ser Tyr Leu Leu Met 
            100                 105                 110         


Phe Ser Asp Gly Gly Arg Asn Trp Lys Gln Tyr Arg Arg Glu Glu Ser 
        115                 120                 125             


Ile Trp Gly Phe Pro Gly Asn Thr Asn Ala Asp Ser Val Val His Tyr 
    130                 135                 140                 


Arg Leu Gln Pro Pro Phe Glu Ala Arg Phe Leu Arg Phe Leu Pro Leu 
145                 150                 155                 160 


Ala Trp Asn Pro Arg Gly Arg Ile Gly Met Arg Ile Glu Val Tyr Gly 
                165                 170                 175     


Cys Ala Tyr Lys Ser Glu Val Val Tyr Phe Asp Gly Gln Ser Ala Leu 
            180                 185                 190         


Leu Tyr Thr Leu Asp Lys Lys Pro Leu Lys Pro Ile Arg Asp Val Ile 
        195                 200                 205             


Ser Leu Lys Phe Lys Ala Met Gln Ser Asn Gly Ile Leu Leu His Arg 
    210                 215                 220                 


Glu Gly Gln His Gly Asn His Ile Thr Leu Glu Leu Ile Lys Gly Lys 
225                 230                 235                 240 


Leu Val Phe Phe Leu Asn Ser Gly Asn Ala Lys Leu Pro Ser Thr Ile 
                245                 250                 255     


Ala Pro Val Thr Leu Thr Leu Gly Ser Leu Leu Asp Asp Gln His Trp 
            260                 265                 270         


His Ser Val Leu Ile Glu Leu Leu Asp Thr Gln Val Asn Phe Thr Val 
        275                 280                 285             


Asp Lys His Thr His His Phe Gln Ala Lys Gly Asp Ser Ser Asn Leu 
    290                 295                 300                 


Asp Leu Asn Phe Glu Ile Ser Phe Gly Gly Ile Leu Ser Pro Gly Arg 
305                 310                 315                 320 


Ser Arg Ala Phe Thr Arg Lys Ser Phe His Gly Cys Leu Glu Asn Leu 
                325                 330                 335     


Tyr Tyr Asn Gly Val Asp Val Thr Glu Leu Ala Lys Lys His Lys Pro 
            340                 345                 350         


Gln Ile Leu Met Met Gly Asn Val Ser Phe Ser Cys Pro Gln Pro Gln 
        355                 360                 365             


Thr Val Pro Val Thr Phe Leu Ser Ser Arg Ser Tyr Leu Ala Leu Pro 
    370                 375                 380                 


Gly Asn Ser Gly Glu Asp Lys Val Ser Val Thr Phe Gln Phe Arg Thr 
385                 390                 395                 400 


Trp Asn Arg Ala Gly His Leu Leu Phe Gly Glu Leu Gln Arg Gly Ser 
                405                 410                 415     


Gly Ser Phe Val Leu Phe Leu Lys Asp Gly Lys Leu Lys Leu Ser Leu 
            420                 425                 430         


Phe Gln Ala Gly Gln Ser Pro Arg Asn Val Thr Ala Gly Ala Gly Leu 
        435                 440                 445             


Asn Asp Gly Gln Trp His Ser Val Ser Phe Ser Ala Lys Trp Ser His 
    450                 455                 460                 


Met Asn Val Val Val Asp Asp Asp Thr Ala Val Gln Pro Leu Val Ala 
465                 470                 475                 480 


Val Leu Ile Asp Ser Gly Asp Thr Tyr Tyr Phe Gly Ala Leu Tyr Glu 
                485                 490                 495     


Gln Ser Cys Glu Ala His Lys His Arg Gly Asn Pro Ser Gly Leu Tyr 
            500                 505                 510         


Tyr Ile Asp Ala Asp Gly Ser Gly Pro Leu Gly Pro Phe Leu Val Tyr 
        515                 520                 525             


Cys Asn Met Thr Asp Ser Ala Trp Thr Val Val Arg His Gly Gly Pro 
    530                 535                 540                 


Asp Ala Val Thr Leu Arg Gly Ala Pro Ser Gly His Pro Leu Ser Ala 
545                 550                 555                 560 


Val Ser Phe Ala Tyr Ala Ala Gly Ala Gly Gln Leu Arg Ala Ala Val 
                565                 570                 575     


Asn Leu Ala Glu Arg Cys Glu Gln Arg Leu Ala Leu Arg Cys Gly Thr 
            580                 585                 590         


Ala Arg Arg Pro Asp Ser Arg Asp Gly Thr Pro Leu Ser Trp Trp Val 
        595                 600                 605             


Gly Arg Thr Asn Glu Thr His Thr Ser Trp Gly Gly Ser Leu Pro Asp 
    610                 615                 620                 


Ala Gln Lys Cys Thr Cys Gly Leu Glu Gly Asn Cys Ile Asp Ser Gln 
625                 630                 635                 640 


Tyr Tyr Cys Asn Cys Asp Ala Gly Gln Asn Glu Trp Thr Ser Asp Thr 
                645                 650                 655     


Ile Val Leu Ser Gln Lys Glu His Leu Pro Val Thr Gln Ile Val Met 
            660                 665                 670         


Thr Asp Thr Gly Gln Pro His Ser Glu Ala Asp Tyr Thr Leu Gly Pro 
        675                 680                 685             


Leu Leu Cys Arg Gly Asp Lys Ser Phe Trp Asn Ser Ala Ser Phe Asn 
    690                 695                 700                 


Thr Glu Thr Ser Tyr Leu His Phe Pro Ala Phe His Gly Glu Leu Thr 
705                 710                 715                 720 


Ala Asp Val Cys Phe Phe Phe Lys Thr Thr Val Ser Ser Gly Val Phe 
                725                 730                 735     


Met Glu Asn Leu Gly Ile Thr Asp Phe Ile Arg Ile Glu Leu Arg Ala 
            740                 745                 750         


Pro Thr Glu Val Thr Phe Ser Phe Asp Val Gly Asn Gly Pro Cys Glu 
        755                 760                 765             


Val Thr Val Gln Ser Pro Thr Pro Phe Asn Asp Asn Gln Trp His His 
    770                 775                 780                 


Val Arg Ala Glu Arg Asn Val Lys Gly Ala Ser Leu Gln Val Asp Gln 
785                 790                 795                 800 


Leu Pro Gln Lys Met Gln Pro Ala Pro Ala Asp Gly His Val Arg Leu 
                805                 810                 815     


Gln Leu Asn Ser Gln Leu Phe Ile Gly Gly Thr Ala Thr Arg Gln Arg 
            820                 825                 830         


Gly Phe Leu Gly Cys Ile Arg Ser Leu Gln Leu Asn Gly Val Ala Leu 
        835                 840                 845             


Asp Leu Glu Glu Arg Ala Thr Val Thr Pro Gly Val Glu Pro Gly Cys 
    850                 855                 860                 


Ala Gly His Cys Ser Thr Tyr Gly His Leu Cys Arg Asn Gly Gly Arg 
865                 870                 875                 880 


Cys Arg Glu Lys Arg Arg Gly Val Thr Cys Asp Cys Ala Phe Ser Ala 
                885                 890                 895     


Tyr Asp Gly Pro Phe Cys Ser Asn Glu Ile Ser Ala Tyr Phe Ala Thr 
            900                 905                 910         


Gly Ser Ser Met Thr Tyr His Phe Gln Glu His Tyr Thr Leu Ser Glu 
        915                 920                 925             


Asn Ser Ser Ser Leu Val Ser Ser Leu His Arg Asp Val Thr Leu Thr 
    930                 935                 940                 


Arg Glu Met Ile Thr Leu Ser Phe Arg Thr Thr Arg Thr Pro Ser Leu 
945                 950                 955                 960 


Leu Leu Lys Phe Ala Asp 
                965     


<210>  3175
<211>  180
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3175

Xaa Arg Asp Val Thr Leu Thr Arg Glu Met Ile Thr Leu Ser Phe Arg 
1               5                   10                  15      


Thr Thr Arg Thr Pro Ser Leu Leu Leu Tyr Val Ser Ser Phe Tyr Glu 
            20                  25                  30          


Glu Tyr Leu Ser Val Ile Leu Ala Asn Asn Gly Ser Leu Gln Ile Arg 
        35                  40                  45              


Tyr Lys Leu Asp Arg His Gln Asn Pro Asp Ala Phe Thr Phe Asp Phe 
    50                  55                  60                  


Lys Asn Met Ala Asp Gly Gln Leu His Gln Val Lys Ile Asn Arg Glu 
65                  70                  75                  80  


Glu Ala Val Val Met Val Glu Val Asn Gln Ser Ala Lys Lys Gln Val 
                85                  90                  95      


Ile Leu Ser Ser Gly Thr Glu Phe Asn Ala Val Lys Ser Leu Ile Leu 
            100                 105                 110         


Gly Lys Val Leu Gly Arg Ser Gly Pro Val Asp Glu Gly Glu Pro Leu 
        115                 120                 125             


Val Asn Ala Asp Arg Arg Asp Ser Ala Val Ile Gly Gly Val Ile Ala 
    130                 135                 140                 


Val Glu Ile Phe Ile Leu Leu Cys Ile Thr Ala Ile Ala Ile Arg Ile 
145                 150                 155                 160 


Tyr Gln Gln Arg Lys Leu Arg Lys Glu Asn Glu Ser Lys Val Ser Lys 
                165                 170                 175     


Lys Glu Glu Cys 
            180 


<210>  3176
<211>  167
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3176

Xaa Ser Ala Ala Pro Gly Leu Thr Arg Thr Ser Asp Thr Ile Val Leu 
1               5                   10                  15      


Ser Gln Lys Glu His Leu Pro Val Thr Gln Ile Val Met Thr Asp Thr 
            20                  25                  30          


Gly Gln Pro His Ser Glu Ala Asp Tyr Thr Leu Gly Pro Leu Leu Cys 
        35                  40                  45              


Arg Gly Asp Thr Arg Leu Leu Lys Val Trp Arg Arg Glu Ser Val Ile 
    50                  55                  60                  


Phe Glu Ile Phe Pro Ser Leu Phe Gly Arg Leu Arg Trp Glu Asp Gly 
65                  70                  75                  80  


Leu Ser Gln Gly Val Gln His Lys Pro Gly Gln Asp Glu Ser Phe Trp 
                85                  90                  95      


Asn Ser Ala Ser Phe Asn Thr Glu Thr Ser Tyr Leu His Phe Pro Ala 
            100                 105                 110         


Phe His Gly Glu Leu Thr Ala Asp Val Cys Phe Phe Phe Lys Thr Thr 
        115                 120                 125             


Val Ser Ser Gly Val Phe Met Glu Asn Leu Gly Ile Thr Asp Phe Ile 
    130                 135                 140                 


Arg Ile Glu Leu Arg Gly Arg Leu Ala Thr Leu Asp Lys Ser Gln Gly 
145                 150                 155                 160 


Thr His Tyr Leu Ala Ile Lys 
                165         


<210>  3177
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  3177

Met Ala Ile Asn Arg Phe Arg Leu Glu Asn Asp Leu Glu Glu Leu Ala 
1               5                   10                  15      


Leu Tyr Gln Ile Gln Leu Leu Lys Asp Leu Arg His Thr Glu Asn Glu 
            20                  25                  30          


Glu Asp Lys Val Ser Ser Ser Ser Phe Arg Gln Arg Met Leu Gly Asn 
        35                  40                  45              


Leu Leu Arg Pro Pro Tyr Glu Arg Pro Glu Leu Pro Thr Cys Leu Tyr 
    50                  55                  60                  


Val Ile Gly Leu Thr Gly Ile Ser Gly Ser Gly Lys Ser Ser Ile Ala 
65                  70                  75                  80  


Gln Arg Leu Lys Gly Leu Gly Ala Phe Val Ile Asp Ser Asp His Leu 
                85                  90                  95      


Gly His Arg Ala Tyr Ala Pro Gly Gly Pro Ala Tyr Gln Pro Val Val 
            100                 105                 110         


Glu Ala Phe Gly 
        115     


<210>  3178
<211>  91
<212>  PRT
<213>  Homo Sapiens

<400>  3178

Met Ala Val Phe Arg Ser Gly Leu Leu Val Leu Thr Thr Pro Leu Ala 
1               5                   10                  15      


Ser Leu Ala Pro Arg Leu Ala Ser Ile Leu Thr Ser Ala Ala Arg Leu 
            20                  25                  30          


Val Asn His Thr Leu Tyr Val His Leu Gln Pro Gly Met Ser Leu Glu 
        35                  40                  45              


Gly Pro Ala Gln Pro Gln Ser Ser Pro Val Gln Ala Thr Phe Glu Val 
    50                  55                  60                  


Leu Asp Phe Ile Thr His Leu Tyr Ala Gly Ala Asp Val His Arg His 
65                  70                  75                  80  


Leu Asp Val Arg Ile Leu Leu Thr Asn Ile Arg 
                85                  90      


<210>  3179
<211>  147
<212>  PRT
<213>  Homo Sapiens

<400>  3179

Met Ala Val Phe Arg Ser Gly Leu Leu Val Leu Thr Thr Pro Leu Ala 
1               5                   10                  15      


Ser Leu Ala Pro Arg Leu Ala Ser Ile Leu Thr Ser Ala Ala Arg Leu 
            20                  25                  30          


Val Asn His Thr Leu Tyr Val His Leu Gln Pro Gly Met Ser Leu Glu 
        35                  40                  45              


Gly Pro Ala Gln Pro Gln Ser Ser Pro Val Gln Ala Thr Phe Glu Val 
    50                  55                  60                  


Leu Asp Phe Ile Thr His Leu Tyr Ala Gly Ala Asp Val His Arg His 
65                  70                  75                  80  


Leu Asp Val Arg Ile Leu Leu Thr Asn Ile Arg Thr Lys Ser Thr Phe 
                85                  90                  95      


Leu Pro Pro Leu Pro Thr Ser Val Gln Asn Leu Ala His Pro Pro Glu 
            100                 105                 110         


Val Val Leu Thr Asp Phe Gln Thr Leu Asp Gly Ser Gln Tyr Asn Pro 
        115                 120                 125             


Val Lys Gln Gln Leu Val Arg Tyr Ala Thr Ser Cys Tyr Ser Cys Cys 
    130                 135                 140                 


Pro Arg Leu 
145         


<210>  3180
<211>  219
<212>  PRT
<213>  Homo Sapiens

<400>  3180

Met Ala Val Phe Arg Ser Gly Leu Leu Val Leu Thr Thr Pro Leu Ala 
1               5                   10                  15      


Ser Leu Ala Pro Arg Leu Ala Ser Ile Leu Thr Ser Ala Ala Arg Leu 
            20                  25                  30          


Val Asn His Thr Leu Tyr Val His Leu Gln Pro Gly Met Ser Leu Glu 
        35                  40                  45              


Gly Pro Ala Gln Pro Gln Ser Ser Pro Val Gln Ala Thr Phe Glu Val 
    50                  55                  60                  


Leu Asp Phe Ile Thr His Leu Tyr Ala Gly Ala Asp Val His Arg His 
65                  70                  75                  80  


Leu Asp Val Arg Ile Leu Leu Thr Asn Ile Arg Thr Lys Ser Thr Phe 
                85                  90                  95      


Leu Pro Pro Leu Pro Thr Ser Val Gln Asn Leu Ala His Pro Pro Glu 
            100                 105                 110         


Val Val Leu Thr Asp Phe Gln Thr Leu Asp Gly Ser Gln Tyr Asn Pro 
        115                 120                 125             


Val Lys Gln Gln Leu Val Arg Tyr Ala Thr Ser Cys Tyr Ser Cys Cys 
    130                 135                 140                 


Pro Arg Leu Ala Ser Val Leu Leu Tyr Ser Asp Tyr Gly Ile Gly Glu 
145                 150                 155                 160 


Val Pro Val Glu Pro Leu Asp Val Pro Leu Pro Ser Thr Ile Arg Pro 
                165                 170                 175     


Ala Ser Pro Val Ala Gly Ser Pro Lys Gln Pro Val Arg Gly Tyr Tyr 
            180                 185                 190         


Arg Gly Ala Val Gly Gly Thr Phe Asp Arg Leu His Asn Ala His Lys 
        195                 200                 205             


Val Leu Leu Ser Val Ala Cys Ile Leu Ala Gln 
    210                 215                 


<210>  3181
<211>  564
<212>  PRT
<213>  Homo Sapiens

<400>  3181

Met Ala Val Phe Arg Ser Gly Leu Leu Val Leu Thr Thr Pro Leu Ala 
1               5                   10                  15      


Ser Leu Ala Pro Arg Leu Ala Ser Ile Leu Thr Ser Ala Ala Arg Leu 
            20                  25                  30          


Val Asn His Thr Leu Tyr Val His Leu Gln Pro Gly Met Ser Leu Glu 
        35                  40                  45              


Gly Pro Ala Gln Pro Gln Ser Ser Pro Val Gln Ala Thr Phe Glu Val 
    50                  55                  60                  


Leu Asp Phe Ile Thr His Leu Tyr Ala Gly Ala Asp Val His Arg His 
65                  70                  75                  80  


Leu Asp Val Arg Ile Leu Leu Thr Asn Ile Arg Thr Lys Ser Thr Phe 
                85                  90                  95      


Leu Pro Pro Leu Pro Thr Ser Val Gln Asn Leu Ala His Pro Pro Glu 
            100                 105                 110         


Val Val Leu Thr Asp Phe Gln Thr Leu Asp Gly Ser Gln Tyr Asn Pro 
        115                 120                 125             


Val Lys Gln Gln Leu Val Arg Tyr Ala Thr Ser Cys Tyr Ser Cys Cys 
    130                 135                 140                 


Pro Arg Leu Ala Ser Val Leu Leu Tyr Ser Asp Tyr Gly Ile Gly Glu 
145                 150                 155                 160 


Val Pro Val Glu Pro Leu Asp Val Pro Leu Pro Ser Thr Ile Arg Pro 
                165                 170                 175     


Ala Ser Pro Val Ala Gly Ser Pro Lys Gln Pro Val Arg Gly Tyr Tyr 
            180                 185                 190         


Arg Gly Ala Val Gly Gly Thr Phe Asp Arg Leu His Asn Ala His Lys 
        195                 200                 205             


Val Leu Leu Ser Val Ala Cys Ile Leu Ala Gln Glu Gln Leu Val Val 
    210                 215                 220                 


Gly Val Ala Asp Lys Asp Leu Leu Lys Ser Lys Leu Leu Pro Glu Leu 
225                 230                 235                 240 


Leu Gln Pro Tyr Thr Glu Arg Val Glu His Leu Ser Glu Phe Leu Val 
                245                 250                 255     


Asp Ile Lys Pro Ser Leu Thr Phe Asp Val Ile Pro Leu Leu Asp Pro 
            260                 265                 270         


Tyr Gly Pro Ala Gly Ser Asp Pro Ser Leu Glu Phe Leu Val Val Ser 
        275                 280                 285             


Glu Glu Thr Tyr Arg Gly Gly Met Ala Ile Asn Arg Phe Arg Leu Glu 
    290                 295                 300                 


Asn Asp Leu Glu Glu Leu Ala Leu Tyr Gln Ile Gln Leu Leu Lys Asp 
305                 310                 315                 320 


Leu Arg His Thr Glu Asn Glu Glu Asp Lys Val Ser Ser Ser Ser Phe 
                325                 330                 335     


Arg Gln Arg Met Leu Gly Asn Leu Leu Arg Pro Pro Tyr Glu Arg Pro 
            340                 345                 350         


Glu Leu Pro Thr Cys Leu Tyr Val Ile Gly Leu Thr Gly Ile Ser Gly 
        355                 360                 365             


Ser Gly Lys Ser Ser Ile Ala Gln Arg Leu Lys Gly Leu Gly Ala Phe 
    370                 375                 380                 


Val Ile Asp Ser Asp His Leu Gly His Arg Ala Tyr Ala Pro Gly Gly 
385                 390                 395                 400 


Pro Ala Tyr Gln Pro Val Val Glu Ala Phe Gly Thr Asp Ile Leu His 
                405                 410                 415     


Lys Asp Gly Ile Ile Asn Arg Lys Val Leu Gly Ser Arg Val Phe Gly 
            420                 425                 430         


Asn Lys Lys Gln Leu Lys Ile Leu Thr Asp Ile Met Trp Pro Ile Ile 
        435                 440                 445             


Ala Lys Leu Ala Arg Glu Glu Met Asp Arg Ala Val Ala Glu Gly Lys 
    450                 455                 460                 


Arg Val Cys Val Ile Asp Ala Ala Val Leu Leu Glu Ala Gly Trp Gln 
465                 470                 475                 480 


Asn Leu Val His Glu Val Trp Thr Ala Val Ile Pro Glu Thr Glu Ala 
                485                 490                 495     


Val Arg Arg Ile Val Glu Arg Asp Gly Leu Ser Glu Ala Ala Ala Gln 
            500                 505                 510         


Ser Arg Leu Gln Ser Gln Met Ser Gly Gln Gln Leu Val Glu Gln Ser 
        515                 520                 525             


His Val Val Leu Ser Thr Leu Trp Glu Pro His Ile Thr Gln Arg Gln 
    530                 535                 540                 


Val Glu Lys Ala Trp Ala Leu Leu Gln Lys Arg Ile Pro Lys Thr His 
545                 550                 555                 560 


Gln Ala Leu Asp 
                


<210>  3182
<211>  564
<212>  PRT
<213>  Homo Sapiens

<400>  3182

Met Ala Val Phe Arg Ser Gly Leu Leu Val Leu Thr Thr Pro Leu Ala 
1               5                   10                  15      


Ser Leu Ala Pro Arg Leu Ala Ser Ile Leu Thr Ser Ala Ala Arg Leu 
            20                  25                  30          


Val Asn His Thr Leu Tyr Val His Leu Gln Pro Gly Met Ser Leu Glu 
        35                  40                  45              


Gly Pro Ala Gln Pro Gln Ser Ser Pro Val Gln Ala Thr Phe Glu Val 
    50                  55                  60                  


Leu Asp Phe Ile Thr His Leu Tyr Ala Gly Ala Asp Val His Arg His 
65                  70                  75                  80  


Leu Asp Val Arg Ile Leu Leu Thr Asn Ile Arg Thr Lys Ser Thr Phe 
                85                  90                  95      


Leu Pro Pro Leu Pro Thr Ser Val Gln Asn Leu Ala His Pro Pro Glu 
            100                 105                 110         


Val Val Leu Thr Asp Phe Gln Thr Leu Asp Gly Ser Gln Tyr Asn Pro 
        115                 120                 125             


Val Lys Gln Gln Leu Val Arg Tyr Ala Thr Ser Cys Tyr Ser Cys Cys 
    130                 135                 140                 


Pro Arg Leu Ala Ser Val Leu Leu Tyr Ser Asp Tyr Gly Ile Gly Glu 
145                 150                 155                 160 


Val Pro Val Glu Pro Leu Asp Val Pro Leu Pro Ser Thr Ile Arg Pro 
                165                 170                 175     


Ala Ser Pro Val Ala Gly Ser Pro Lys Gln Pro Val Arg Gly Tyr Tyr 
            180                 185                 190         


Arg Gly Ala Val Gly Gly Thr Phe Asp Arg Leu His Asn Ala His Lys 
        195                 200                 205             


Val Leu Leu Ser Val Ala Cys Ile Leu Ala Gln Glu Gln Leu Val Val 
    210                 215                 220                 


Gly Val Ala Asp Lys Asp Leu Leu Lys Ser Lys Leu Leu Pro Glu Leu 
225                 230                 235                 240 


Leu Gln Pro Tyr Thr Glu Arg Val Glu His Leu Ser Glu Phe Leu Val 
                245                 250                 255     


Asp Ile Lys Pro Ser Leu Thr Phe Asp Val Ile Pro Leu Leu Asp Pro 
            260                 265                 270         


Tyr Gly Pro Ala Gly Ser Asp Pro Ser Leu Glu Phe Leu Val Val Ser 
        275                 280                 285             


Glu Glu Thr Tyr Arg Gly Gly Met Ala Ile Asn Arg Phe Arg Leu Glu 
    290                 295                 300                 


Asn Asp Leu Glu Glu Leu Ala Leu Tyr Gln Ile Gln Leu Leu Lys Asp 
305                 310                 315                 320 


Leu Arg His Thr Glu Asn Glu Glu Asp Lys Val Ser Ser Ser Ser Phe 
                325                 330                 335     


Arg Gln Arg Met Leu Gly Asn Leu Leu Arg Pro Pro Tyr Glu Arg Pro 
            340                 345                 350         


Glu Leu Pro Thr Cys Leu Tyr Val Ile Gly Leu Thr Gly Ile Ser Gly 
        355                 360                 365             


Ser Gly Lys Ser Ser Ile Ala Gln Arg Leu Lys Gly Leu Gly Ala Phe 
    370                 375                 380                 


Val Ile Asp Ser Asp His Leu Gly His Arg Ala Tyr Ala Pro Gly Gly 
385                 390                 395                 400 


Pro Ala Tyr Gln Pro Val Val Glu Ala Phe Gly Thr Asp Ile Leu His 
                405                 410                 415     


Lys Asp Gly Ile Ile Asn Arg Lys Val Leu Gly Ser Arg Val Phe Gly 
            420                 425                 430         


Asn Lys Lys Gln Leu Lys Ile Leu Thr Asp Ile Met Trp Pro Ile Ile 
        435                 440                 445             


Ala Lys Leu Ala Arg Glu Glu Met Asp Arg Ala Val Ala Glu Gly Lys 
    450                 455                 460                 


Arg Val Cys Val Ile Asp Ala Ala Val Leu Leu Glu Ala Gly Trp Gln 
465                 470                 475                 480 


Asn Leu Val His Glu Val Trp Thr Ala Val Ile Pro Glu Thr Glu Ala 
                485                 490                 495     


Val Arg Arg Ile Val Glu Arg Asp Gly Leu Ser Glu Ala Ala Ala Gln 
            500                 505                 510         


Ser Arg Leu Gln Ser Gln Met Ser Gly Gln Gln Leu Val Glu Gln Ser 
        515                 520                 525             


His Val Val Leu Ser Thr Leu Trp Glu Pro His Ile Thr Gln Arg Gln 
    530                 535                 540                 


Val Glu Lys Ala Trp Ala Leu Leu Gln Lys Arg Ile Pro Lys Thr His 
545                 550                 555                 560 


Gln Ala Leu Asp 
                


<210>  3183
<211>  98
<212>  PRT
<213>  Homo Sapiens

<400>  3183

Met Arg Thr Pro Arg Leu Arg Ala Gln Pro Arg Gly Ala Val Tyr Gln 
1               5                   10                  15      


Ala Pro Ser Pro Pro Pro Ala Pro Val Gly Leu Gly Ser Met Ala Val 
            20                  25                  30          


Phe Arg Ser Gly Leu Leu Val Leu Thr Thr Pro Leu Ala Ser Leu Ala 
        35                  40                  45              


Pro Arg Leu Ala Ser Ile Leu Thr Ser Ala Ala Arg Leu Val Asn His 
    50                  55                  60                  


Thr Leu Tyr Val His Leu Gln Pro Gly Met Ser Leu Glu Gly Pro Ala 
65                  70                  75                  80  


Gln Pro Gln Ser Ser Pro Val Gln Ala Thr Phe Glu Val Leu Asp Phe 
                85                  90                  95      


Ile Thr 
        


<210>  3184
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  3184

Met Arg Thr Pro Arg Leu Arg Ala Gln Pro Arg Gly Ala Val Tyr Gln 
1               5                   10                  15      


Ala Pro Ser Pro Pro Pro Ala Pro Val Gly Leu Gly Ser Met Ala Val 
            20                  25                  30          


Phe Arg Ser Gly Leu Leu Val Leu Thr Thr Pro Leu Ala Ser Leu Ala 
        35                  40                  45              


Pro Arg Leu Ala Ser Ile Leu Thr Ser Ala Ala Arg Leu Val Asn His 
    50                  55                  60                  


Thr Leu Tyr Val His Leu Gln Pro Gly Met Ser Leu Glu Gly Pro Ala 
65                  70                  75                  80  


Gln Pro Gln Ser Ser Pro Val Gln Ala Thr Phe Glu Val Leu Asp Phe 
                85                  90                  95      


Ile Thr His Leu Tyr Ala Gly Ala Asp Val His Arg His Leu Asp Val 
            100                 105                 110         


Arg Ile Leu Leu Thr Asn Ile Arg Thr Lys Ser Thr Phe Leu Pro Pro 
        115                 120                 125             


<210>  3185
<211>  593
<212>  PRT
<213>  Homo Sapiens

<400>  3185

Met Arg Thr Pro Arg Leu Arg Ala Gln Pro Arg Gly Ala Val Tyr Gln 
1               5                   10                  15      


Ala Pro Ser Pro Pro Pro Ala Pro Val Gly Leu Gly Ser Met Ala Val 
            20                  25                  30          


Phe Arg Ser Gly Leu Leu Val Leu Thr Thr Pro Leu Ala Ser Leu Ala 
        35                  40                  45              


Pro Arg Leu Ala Ser Ile Leu Thr Ser Ala Ala Arg Leu Val Asn His 
    50                  55                  60                  


Thr Leu Tyr Val His Leu Gln Pro Gly Met Ser Leu Glu Gly Pro Ala 
65                  70                  75                  80  


Gln Pro Gln Ser Ser Pro Val Gln Ala Thr Phe Glu Val Leu Asp Phe 
                85                  90                  95      


Ile Thr His Leu Tyr Ala Gly Ala Asp Val His Arg His Leu Asp Val 
            100                 105                 110         


Arg Ile Leu Leu Thr Asn Ile Arg Thr Lys Ser Thr Phe Leu Pro Pro 
        115                 120                 125             


Leu Pro Thr Ser Val Gln Asn Leu Ala His Pro Pro Glu Val Val Leu 
    130                 135                 140                 


Thr Asp Phe Gln Thr Leu Asp Gly Ser Gln Tyr Asn Pro Val Lys Gln 
145                 150                 155                 160 


Gln Leu Val Arg Tyr Ala Thr Ser Cys Tyr Ser Cys Cys Pro Arg Leu 
                165                 170                 175     


Ala Ser Val Leu Leu Tyr Ser Asp Tyr Gly Ile Gly Glu Val Pro Val 
            180                 185                 190         


Glu Pro Leu Asp Val Pro Leu Pro Ser Thr Ile Arg Pro Ala Ser Pro 
        195                 200                 205             


Val Ala Gly Ser Pro Lys Gln Pro Val Arg Gly Tyr Tyr Arg Gly Ala 
    210                 215                 220                 


Val Gly Gly Thr Phe Asp Arg Leu His Asn Ala His Lys Val Leu Leu 
225                 230                 235                 240 


Ser Val Ala Cys Ile Leu Ala Gln Glu Gln Leu Val Val Gly Val Ala 
                245                 250                 255     


Asp Lys Asp Leu Leu Lys Ser Lys Leu Leu Pro Glu Leu Leu Gln Pro 
            260                 265                 270         


Tyr Thr Glu Arg Val Glu His Leu Ser Glu Phe Leu Val Asp Ile Lys 
        275                 280                 285             


Pro Ser Leu Thr Phe Asp Val Ile Pro Leu Leu Asp Pro Tyr Gly Pro 
    290                 295                 300                 


Ala Gly Ser Asp Pro Ser Leu Glu Phe Leu Val Val Ser Glu Glu Thr 
305                 310                 315                 320 


Tyr Arg Gly Gly Met Ala Ile Asn Arg Phe Arg Leu Glu Asn Asp Leu 
                325                 330                 335     


Glu Glu Leu Ala Leu Tyr Gln Ile Gln Leu Leu Lys Asp Leu Arg His 
            340                 345                 350         


Thr Glu Asn Glu Glu Asp Lys Val Ser Ser Ser Ser Phe Arg Gln Arg 
        355                 360                 365             


Met Leu Gly Asn Leu Leu Arg Pro Pro Tyr Glu Arg Pro Glu Leu Pro 
    370                 375                 380                 


Thr Cys Leu Tyr Val Ile Gly Leu Thr Gly Ile Ser Gly Ser Gly Lys 
385                 390                 395                 400 


Ser Ser Ile Ala Gln Arg Leu Lys Gly Leu Gly Ala Phe Val Ile Asp 
                405                 410                 415     


Ser Asp His Leu Gly His Arg Ala Tyr Ala Pro Gly Gly Pro Ala Tyr 
            420                 425                 430         


Gln Pro Val Val Glu Ala Phe Gly Thr Asp Ile Leu His Lys Asp Gly 
        435                 440                 445             


Ile Ile Asn Arg Lys Val Leu Gly Ser Arg Val Phe Gly Asn Lys Lys 
    450                 455                 460                 


Gln Leu Lys Ile Leu Thr Asp Ile Met Trp Pro Ile Ile Ala Lys Leu 
465                 470                 475                 480 


Ala Arg Glu Glu Met Asp Arg Ala Val Ala Glu Gly Lys Arg Val Cys 
                485                 490                 495     


Val Ile Asp Ala Ala Val Leu Leu Glu Ala Gly Trp Gln Asn Leu Val 
            500                 505                 510         


His Glu Val Trp Thr Ala Val Ile Pro Glu Thr Glu Ala Val Arg Arg 
        515                 520                 525             


Ile Val Glu Arg Asp Gly Leu Ser Glu Ala Ala Ala Gln Ser Arg Leu 
    530                 535                 540                 


Gln Ser Gln Met Ser Gly Gln Gln Leu Val Glu Gln Ser His Val Val 
545                 550                 555                 560 


Leu Ser Thr Leu Trp Glu Pro His Ile Thr Gln Arg Gln Val Glu Lys 
                565                 570                 575     


Ala Trp Ala Leu Leu Gln Lys Arg Ile Pro Lys Thr His Gln Ala Leu 
            580                 585                 590         


Asp 
    


<210>  3186
<211>  96
<212>  PRT
<213>  Homo Sapiens

<400>  3186

Met Arg Thr Pro Arg Leu Arg Ala Gln Pro Arg Gly Ala Val Tyr Gln 
1               5                   10                  15      


Ala Pro Ser Pro Pro Pro Ala Pro Val Val Gln Asn Leu Ala His Pro 
            20                  25                  30          


Pro Glu Val Val Leu Thr Asp Phe Gln Thr Leu Asp Gly Ser Gln Tyr 
        35                  40                  45              


Asn Pro Val Lys Gln Gln Leu Val Arg Tyr Ala Thr Ser Cys Tyr Ser 
    50                  55                  60                  


Cys Cys Pro Arg Leu Ala Ser Val Leu Leu Tyr Ser Asp Tyr Gly Ile 
65                  70                  75                  80  


Gly Glu Val Pro Val Glu Pro Leu Asp Val Pro Leu Pro Ser Thr Ile 
                85                  90                  95      


<210>  3187
<211>  438
<212>  PRT
<213>  Homo Sapiens

<400>  3187

Met Leu Ser Arg Trp Ser Ala Ser Phe Thr Val Thr Lys Gly Lys Ser 
1               5                   10                  15      


Ser Thr Gln Glu Ala Thr Gly Gln Ala Val Ser Thr Ala His Pro Pro 
            20                  25                  30          


Thr Gly Lys Arg Leu Lys Lys Thr Pro Glu Lys Lys Thr Gly Asn Lys 
        35                  40                  45              


Asp Cys Lys Ala Asp Ile Ala Phe Leu Ile Asp Gly Ser Phe Asn Ile 
    50                  55                  60                  


Gly Gln Arg Arg Phe Asn Leu Gln Lys Asn Phe Val Gly Lys Val Ala 
65                  70                  75                  80  


Leu Met Leu Gly Ile Gly Thr Glu Gly Pro His Val Gly Leu Val Gln 
                85                  90                  95      


Ala Ser Glu His Pro Lys Ile Glu Phe Tyr Leu Lys Asn Phe Thr Ser 
            100                 105                 110         


Ala Lys Asp Val Leu Phe Ala Ile Lys Glu Val Gly Phe Arg Gly Gly 
        115                 120                 125             


Asn Ser Asn Thr Gly Lys Ala Leu Lys His Thr Ala Gln Lys Phe Phe 
    130                 135                 140                 


Thr Val Asp Ala Gly Val Arg Lys Gly Ile Pro Lys Val Val Val Val 
145                 150                 155                 160 


Phe Ile Asp Gly Trp Pro Ser Asp Asp Ile Glu Glu Ala Gly Ile Val 
                165                 170                 175     


Ala Arg Glu Phe Gly Val Asn Val Phe Ile Val Ser Val Ala Lys Pro 
            180                 185                 190         


Ile Pro Glu Glu Leu Gly Met Val Gln Asp Val Thr Phe Val Asp Lys 
        195                 200                 205             


Ala Val Cys Arg Asn Asn Gly Phe Phe Ser Tyr His Met Pro Asn Trp 
    210                 215                 220                 


Phe Gly Thr Thr Lys Tyr Val Lys Pro Leu Val Gln Lys Leu Cys Thr 
225                 230                 235                 240 


His Glu Gln Met Met Cys Ser Lys Thr Cys Tyr Asn Ser Val Asn Ile 
                245                 250                 255     


Ala Phe Leu Ile Asp Gly Ser Ser Ser Val Gly Asp Ser Asn Phe Arg 
            260                 265                 270         


Leu Met Leu Glu Phe Val Ser Asn Ile Ala Lys Thr Phe Glu Ile Ser 
        275                 280                 285             


Asp Ile Gly Ala Lys Ile Ala Ala Val Gln Phe Thr Tyr Asp Gln Arg 
    290                 295                 300                 


Thr Glu Phe Ser Phe Thr Asp Tyr Ser Thr Lys Glu Asn Val Leu Ala 
305                 310                 315                 320 


Val Ile Arg Asn Ile Arg Tyr Met Ser Gly Gly Thr Ala Thr Gly Asp 
                325                 330                 335     


Ala Ile Ser Phe Thr Val Arg Asn Val Phe Gly Pro Ile Arg Glu Ser 
            340                 345                 350         


Pro Asn Lys Asn Phe Leu Val Ile Val Thr Asp Gly Gln Ser Tyr Asp 
        355                 360                 365             


Asp Val Gln Gly Pro Ala Ala Ala Ala His Asp Ala Gly Ile Thr Ile 
    370                 375                 380                 


Phe Ser Val Gly Val Ala Trp Ala Pro Leu Asp Asp Leu Lys Asp Met 
385                 390                 395                 400 


Ala Ser Lys Pro Lys Glu Ser His Ala Phe Phe Thr Arg Glu Phe Thr 
                405                 410                 415     


Gly Leu Glu Pro Ile Val Ser Asp Val Ile Arg Gly Ile Cys Arg Asp 
            420                 425                 430         


Phe Leu Glu Ser Gln Gln 
        435             


<210>  3188
<211>  193
<212>  PRT
<213>  Homo Sapiens

<400>  3188

Met Ser Ala Ala Trp Ile Pro Ala Leu Gly Leu Ala Pro Ile Ala Ile 
1               5                   10                  15      


Thr Cys Phe Thr Arg Gly Leu Asp Ile Arg Lys Glu Lys Ala Asp Val 
            20                  25                  30          


Leu Cys Pro Gly Gly Cys Pro Leu Glu Glu Phe Ser Val Tyr Gly Asn 
        35                  40                  45              


Ile Val Tyr Ala Ser Val Ser Ser Ile Cys Gly Ala Ala Val His Arg 
    50                  55                  60                  


Gly Val Ile Ser Asn Ser Gly Gly Pro Val Arg Val Tyr Ser Leu Pro 
65                  70                  75                  80  


Gly Arg Glu Asn Tyr Ser Ser Val Asp Ala Asn Gly Ile Gln Ser Gln 
                85                  90                  95      


Met Leu Ser Arg Trp Ser Ala Ser Phe Thr Val Thr Lys Gly Lys Ser 
            100                 105                 110         


Ser Thr Gln Glu Ala Thr Gly Gln Ala Val Ser Thr Ala His Pro Pro 
        115                 120                 125             


Thr Gly Lys Arg Leu Lys Lys Thr Pro Glu Lys Lys Thr Gly Asn Lys 
    130                 135                 140                 


Asp Cys Lys Ala Asp Ile Ala Phe Leu Ile Asp Gly Ser Phe Asn Ile 
145                 150                 155                 160 


Gly Gln Arg Arg Phe Asn Leu Gln Lys Asn Phe Val Gly Lys Val Ala 
                165                 170                 175     


Leu Met Leu Gly Ile Gly Thr Glu Gly Pro His Val Gly Leu Val Gln 
            180                 185                 190         


Ala 
    


<210>  3189
<211>  80
<212>  PRT
<213>  Homo Sapiens

<400>  3189

Met Ser Ala Ala Trp Ile Pro Ala Leu Gly Leu Gly Val Cys Leu Leu 
1               5                   10                  15      


Leu Leu Pro Gly Pro Ala Gly Ser Glu Gly Ala Ala Pro Ile Ala Ile 
            20                  25                  30          


Thr Cys Phe Thr Arg Gly Leu Asp Ile Arg Lys Glu Lys Ala Asp Val 
        35                  40                  45              


Leu Cys Pro Gly Gly Cys Pro Leu Glu Glu Phe Ser Val Tyr Gly Asn 
    50                  55                  60                  


Ile Val Tyr Ala Ser Val Ser Ser Ile Cys Gly Ala Ala Val His Arg 
65                  70                  75                  80  


<210>  3190
<211>  513
<212>  PRT
<213>  Homo Sapiens

<400>  3190

Met Ser Ala Ala Trp Ile Pro Ala Leu Gly Leu Gly Val Cys Leu Leu 
1               5                   10                  15      


Leu Leu Pro Gly Pro Ala Gly Ser Glu Gly Ala Ala Pro Ile Ala Ile 
            20                  25                  30          


Thr Cys Phe Thr Arg Gly Leu Asp Ile Arg Lys Glu Lys Ala Asp Val 
        35                  40                  45              


Leu Cys Pro Gly Gly Cys Pro Leu Glu Glu Phe Ser Val Tyr Gly Asn 
    50                  55                  60                  


Ile Val Tyr Ala Ser Val Ser Ser Ile Cys Gly Ala Ala Val His Arg 
65                  70                  75                  80  


Gly Val Ile Ser Asn Ser Gly Gly Pro Val Arg Val Tyr Ser Leu Pro 
                85                  90                  95      


Gly Arg Glu Asn Tyr Ser Ser Val Asp Ala Asn Gly Ile Gln Ser Gln 
            100                 105                 110         


Met Leu Ser Arg Trp Ser Ala Ser Phe Thr Val Thr Lys Gly Lys Ser 
        115                 120                 125             


Ser Thr Gln Glu Ala Thr Gly Gln Ala Val Ser Thr Ala His Pro Pro 
    130                 135                 140                 


Thr Gly Lys Arg Leu Lys Lys Thr Pro Glu Lys Lys Thr Gly Asn Lys 
145                 150                 155                 160 


Asp Cys Lys Ala Asp Ile Ala Phe Leu Ile Asp Gly Ser Phe Asn Ile 
                165                 170                 175     


Gly Gln Arg Arg Phe Asn Leu Gln Lys Asn Phe Val Gly Lys Val Ala 
            180                 185                 190         


Leu Met Leu Gly Ile Gly Thr Glu Gly Pro His Val Gly Leu Val Gln 
        195                 200                 205             


Ala Ser Glu His Pro Lys Ile Glu Phe Tyr Leu Lys Asn Phe Thr Ser 
    210                 215                 220                 


Ala Lys Asp Val Leu Phe Ala Ile Lys Glu Val Gly Phe Arg Gly Gly 
225                 230                 235                 240 


Asn Ser Asn Thr Asp Val Ala Glu Arg Met Ser Ser Thr Thr Val Asp 
                245                 250                 255     


Ser Glu Glu Arg Leu Leu Arg Gly Lys Ala Leu Lys His Thr Ala Gln 
            260                 265                 270         


Lys Phe Phe Thr Val Asp Ala Gly Val Arg Lys Gly Ile Pro Lys Val 
        275                 280                 285             


Val Val Val Phe Ile Asp Gly Trp Pro Ser Asp Asp Ile Glu Glu Ala 
    290                 295                 300                 


Gly Ile Val Ala Arg Glu Phe Gly Val Asn Val Phe Ile Val Ser Val 
305                 310                 315                 320 


Ala Lys Pro Ile Pro Glu Glu Leu Gly Met Val Gln Asp Val Thr Phe 
                325                 330                 335     


Val Asp Lys Ala Val Cys Arg Asn Asn Gly Phe Phe Ser Tyr His Met 
            340                 345                 350         


Pro Asn Trp Phe Gly Thr Thr Lys Tyr Val Lys Pro Leu Val Gln Lys 
        355                 360                 365             


Leu Cys Thr His Glu Gln Met Met Cys Ser Lys Thr Cys Tyr Asn Ser 
    370                 375                 380                 


Val Asn Ile Ala Phe Leu Ile Asp Gly Ser Ser Ser Val Gly Asp Ser 
385                 390                 395                 400 


Asn Phe Arg Leu Met Leu Glu Phe Val Ser Asn Ile Ala Lys Thr Phe 
                405                 410                 415     


Glu Ile Ser Asp Ile Gly Ala Lys Ile Ala Ala Val Gln Phe Thr Tyr 
            420                 425                 430         


Asp Gln Arg Thr Glu Phe Ser Phe Thr Asp Tyr Ser Thr Lys Glu Asn 
        435                 440                 445             


Val Leu Ala Val Ile Arg Asn Ile Arg Tyr Met Ser Gly Gly Thr Ala 
    450                 455                 460                 


Thr Gly Asp Ala Ile Ser Phe Thr Val Arg Asn Val Phe Gly Pro Ile 
465                 470                 475                 480 


Arg Glu Ser Pro Asn Lys Asn Phe Leu Val Ile Val Thr Asp Gly Gln 
                485                 490                 495     


Ser Tyr Asp Asp Val Gln Gly Pro Ala Ala Ala Ala His Asp Ala Ala 
            500                 505                 510         


Lys 
    


<210>  3191
<211>  550
<212>  PRT
<213>  Homo Sapiens

<400>  3191

Met Ser Ala Ala Trp Ile Pro Ala Leu Gly Leu Gly Val Cys Leu Leu 
1               5                   10                  15      


Leu Leu Pro Gly Pro Ala Gly Ser Glu Gly Ala Ala Pro Ile Ala Ile 
            20                  25                  30          


Thr Cys Phe Thr Arg Gly Leu Asp Ile Arg Lys Glu Lys Ala Asp Val 
        35                  40                  45              


Leu Cys Pro Gly Gly Cys Pro Leu Glu Glu Phe Ser Val Tyr Gly Asn 
    50                  55                  60                  


Ile Val Tyr Ala Ser Val Ser Ser Ile Cys Gly Ala Ala Val His Arg 
65                  70                  75                  80  


Gly Val Ile Ser Asn Ser Gly Gly Pro Val Arg Val Tyr Ser Leu Pro 
                85                  90                  95      


Gly Arg Glu Asn Tyr Ser Ser Val Asp Ala Asn Gly Ile Gln Ser Gln 
            100                 105                 110         


Met Leu Ser Arg Trp Ser Ala Ser Phe Thr Val Thr Lys Gly Lys Ser 
        115                 120                 125             


Ser Thr Gln Glu Ala Thr Gly Gln Ala Val Ser Thr Ala His Pro Pro 
    130                 135                 140                 


Thr Gly Lys Arg Leu Lys Lys Thr Pro Glu Lys Lys Thr Gly Asn Lys 
145                 150                 155                 160 


Asp Cys Lys Ala Asp Ile Ala Phe Leu Ile Asp Gly Ser Phe Asn Ile 
                165                 170                 175     


Gly Gln Arg Arg Phe Asn Leu Gln Lys Asn Phe Val Gly Lys Val Ala 
            180                 185                 190         


Leu Met Leu Gly Ile Gly Thr Glu Gly Pro His Val Gly Leu Val Gln 
        195                 200                 205             


Ala Ser Glu His Pro Lys Ile Glu Phe Tyr Leu Lys Asn Phe Thr Ser 
    210                 215                 220                 


Ala Lys Asp Val Leu Phe Ala Ile Lys Glu Val Gly Phe Arg Gly Gly 
225                 230                 235                 240 


Asn Ser Asn Thr Gly Lys Ala Leu Lys His Thr Ala Gln Lys Phe Phe 
                245                 250                 255     


Thr Val Asp Ala Gly Val Arg Lys Gly Ile Pro Lys Val Val Val Val 
            260                 265                 270         


Phe Ile Asp Gly Trp Pro Ser Asp Asp Ile Glu Glu Ala Gly Ile Val 
        275                 280                 285             


Ala Arg Glu Phe Gly Val Asn Val Phe Ile Val Ser Val Ala Lys Pro 
    290                 295                 300                 


Ile Pro Glu Glu Leu Gly Met Val Gln Asp Val Thr Phe Val Asp Lys 
305                 310                 315                 320 


Ala Val Cys Arg Asn Asn Gly Phe Phe Ser Tyr His Met Pro Asn Trp 
                325                 330                 335     


Phe Gly Thr Thr Lys Tyr Val Lys Pro Leu Val Gln Lys Leu Cys Thr 
            340                 345                 350         


His Glu Gln Met Met Cys Ser Lys Thr Cys Tyr Asn Ser Val Asn Ile 
        355                 360                 365             


Ala Phe Leu Ile Asp Gly Ser Ser Ser Val Gly Asp Ser Asn Phe Arg 
    370                 375                 380                 


Leu Met Leu Glu Phe Val Ser Asn Ile Ala Lys Thr Phe Glu Ile Ser 
385                 390                 395                 400 


Asp Ile Gly Ala Lys Ile Ala Ala Val Gln Phe Thr Tyr Asp Gln Arg 
                405                 410                 415     


Thr Glu Phe Ser Phe Thr Asp Tyr Ser Thr Lys Glu Asn Val Leu Ala 
            420                 425                 430         


Val Ile Arg Asn Ile Arg Tyr Met Ser Gly Gly Thr Ala Thr Gly Asp 
        435                 440                 445             


Ala Ile Ser Phe Thr Val Arg Asn Val Phe Gly Pro Ile Arg Glu Ser 
    450                 455                 460                 


Pro Asn Lys Asn Phe Leu Val Ile Val Thr Asp Gly Gln Ser Tyr Asp 
465                 470                 475                 480 


Asp Val Gln Gly Pro Ala Ala Ala Ala His Asp Ala Gly Ile Thr Ile 
                485                 490                 495     


Phe Ser Val Gly Val Ala Trp Ala Pro Leu Asp Asp Leu Lys Asp Met 
            500                 505                 510         


Ala Ser Lys Pro Lys Glu Ser His Ala Phe Phe Thr Arg Glu Phe Thr 
        515                 520                 525             


Gly Leu Glu Pro Ile Val Ser Asp Val Ile Arg Gly Ile Cys Arg Asp 
    530                 535                 540                 


Phe Leu Glu Ser Gln Gln 
545                 550 


<210>  3192
<211>  494
<212>  PRT
<213>  Homo Sapiens

<400>  3192

Met Ser Ala Ala Trp Ile Pro Ala Leu Gly Leu Gly Val Cys Leu Leu 
1               5                   10                  15      


Leu Leu Pro Gly Pro Ala Gly Ser Glu Gly Ala Ala Pro Ile Ala Ile 
            20                  25                  30          


Thr Cys Phe Thr Arg Gly Leu Asp Ile Arg Lys Glu Lys Ala Asp Val 
        35                  40                  45              


Leu Cys Pro Gly Gly Cys Pro Leu Glu Glu Phe Ser Val Tyr Gly Asn 
    50                  55                  60                  


Ile Val Tyr Ala Ser Val Ser Ser Ile Cys Gly Ala Ala Val His Arg 
65                  70                  75                  80  


Gly Val Ile Ser Asn Ser Gly Gly Pro Val Arg Val Tyr Ser Leu Pro 
                85                  90                  95      


Gly Arg Glu Asn Tyr Ser Ser Val Asp Ala Asn Gly Ile Gln Ser Gln 
            100                 105                 110         


Met Leu Ser Arg Trp Ser Ala Ser Phe Thr Val Thr Lys Gly Lys Ser 
        115                 120                 125             


Ser Thr Gln Glu Ala Thr Gly Gln Ala Val Ser Thr Ala His Pro Pro 
    130                 135                 140                 


Thr Gly Lys Arg Leu Lys Lys Thr Pro Glu Lys Lys Thr Gly Asn Lys 
145                 150                 155                 160 


Asp Cys Lys Ala Asp Ile Ala Phe Leu Ile Asp Gly Ser Phe Asn Ile 
                165                 170                 175     


Gly Gln Arg Arg Phe Asn Leu Gln Lys Asn Phe Val Gly Lys Val Ala 
            180                 185                 190         


Leu Met Leu Gly Ile Gly Thr Glu Gly Pro His Val Gly Leu Val Gln 
        195                 200                 205             


Ala Ser Glu His Pro Lys Ile Glu Phe Tyr Leu Lys Asn Phe Thr Ser 
    210                 215                 220                 


Ala Lys Asp Val Leu Phe Ala Ile Lys Glu Val Gly Phe Arg Gly Gly 
225                 230                 235                 240 


Asn Ser Asn Thr Gly Lys Ala Leu Lys His Thr Ala Gln Lys Phe Phe 
                245                 250                 255     


Thr Val Asp Ala Gly Val Arg Lys Gly Ile Pro Lys Val Val Val Val 
            260                 265                 270         


Phe Ile Asp Gly Trp Pro Ser Asp Asp Ile Glu Glu Ala Gly Ile Val 
        275                 280                 285             


Ala Arg Glu Phe Gly Val Asn Val Phe Ile Val Ser Val Ala Lys Pro 
    290                 295                 300                 


Ile Pro Glu Glu Leu Gly Met Val Gln Asp Val Thr Phe Val Asp Lys 
305                 310                 315                 320 


Ala Val Cys Arg Asn Asn Gly Phe Phe Ser Tyr His Met Pro Asn Trp 
                325                 330                 335     


Phe Gly Thr Thr Lys Tyr Val Lys Pro Leu Val Gln Lys Leu Cys Thr 
            340                 345                 350         


His Glu Gln Met Met Cys Ser Lys Thr Cys Tyr Asn Ser Val Asn Ile 
        355                 360                 365             


Ala Phe Leu Ile Asp Gly Ser Ser Ser Val Gly Asp Ser Asn Phe Arg 
    370                 375                 380                 


Leu Met Leu Glu Phe Val Ser Asn Ile Ala Lys Thr Phe Glu Ile Ser 
385                 390                 395                 400 


Asp Ile Gly Ala Lys Ile Ala Ala Val Gln Phe Thr Tyr Asp Gln Arg 
                405                 410                 415     


Thr Glu Phe Ser Phe Thr Asp Tyr Ser Thr Lys Glu Asn Val Leu Ala 
            420                 425                 430         


Val Ile Arg Asn Ile Arg Tyr Met Ser Gly Gly Thr Ala Thr Gly Asp 
        435                 440                 445             


Ala Ile Ser Phe Thr Val Arg Asn Val Phe Gly Pro Ile Arg Glu Ser 
    450                 455                 460                 


Pro Asn Lys Asn Phe Leu Val Ile Val Thr Asp Gly Gln Ser Tyr Asp 
465                 470                 475                 480 


Asp Val Gln Gly Pro Ala Ala Ala Ala His Asp Ala Ala Lys 
                485                 490                 


<210>  3193
<211>  550
<212>  PRT
<213>  Homo Sapiens

<400>  3193

Met Ser Ala Ala Trp Ile Pro Ala Leu Gly Leu Gly Val Cys Leu Leu 
1               5                   10                  15      


Leu Leu Pro Gly Pro Ala Gly Ser Glu Gly Ala Ala Pro Ile Ala Ile 
            20                  25                  30          


Thr Cys Phe Thr Arg Gly Leu Asp Ile Arg Lys Glu Lys Ala Asp Val 
        35                  40                  45              


Leu Cys Pro Gly Gly Cys Pro Leu Glu Glu Phe Ser Val Tyr Gly Asn 
    50                  55                  60                  


Ile Val Tyr Ala Ser Val Ser Ser Ile Cys Gly Ala Ala Val His Arg 
65                  70                  75                  80  


Gly Val Ile Ser Asn Ser Gly Gly Pro Val Arg Val Tyr Ser Leu Pro 
                85                  90                  95      


Gly Arg Glu Asn Tyr Ser Ser Val Asp Ala Asn Gly Ile Gln Ser Gln 
            100                 105                 110         


Met Leu Ser Arg Trp Ser Ala Ser Phe Thr Val Thr Lys Gly Lys Ser 
        115                 120                 125             


Ser Thr Gln Glu Ala Thr Gly Gln Ala Val Ser Thr Ala His Pro Pro 
    130                 135                 140                 


Thr Gly Lys Arg Leu Lys Lys Thr Pro Glu Lys Lys Thr Gly Asn Lys 
145                 150                 155                 160 


Asp Cys Lys Ala Asp Ile Ala Phe Leu Ile Asp Gly Ser Phe Asn Ile 
                165                 170                 175     


Gly Gln Arg Arg Phe Asn Leu Gln Lys Asn Phe Val Gly Lys Val Ala 
            180                 185                 190         


Leu Met Leu Gly Ile Gly Thr Glu Gly Pro His Val Gly Leu Val Gln 
        195                 200                 205             


Ala Ser Glu His Pro Lys Ile Glu Phe Tyr Leu Lys Asn Phe Thr Ser 
    210                 215                 220                 


Ala Lys Asp Val Leu Phe Ala Ile Lys Glu Val Gly Phe Arg Gly Gly 
225                 230                 235                 240 


Asn Ser Asn Thr Gly Lys Ala Leu Lys His Thr Ala Gln Lys Phe Phe 
                245                 250                 255     


Thr Val Asp Ala Gly Val Arg Lys Gly Ile Pro Lys Val Val Val Val 
            260                 265                 270         


Phe Ile Asp Gly Trp Pro Ser Asp Asp Ile Glu Glu Ala Gly Ile Val 
        275                 280                 285             


Ala Arg Glu Phe Gly Val Asn Val Phe Ile Val Ser Val Ala Lys Pro 
    290                 295                 300                 


Ile Pro Glu Glu Leu Gly Met Val Gln Asp Val Thr Phe Val Asp Lys 
305                 310                 315                 320 


Ala Val Cys Arg Asn Asn Gly Phe Phe Ser Tyr His Met Pro Asn Trp 
                325                 330                 335     


Phe Gly Thr Thr Lys Tyr Val Lys Pro Leu Val Gln Lys Leu Cys Thr 
            340                 345                 350         


His Glu Gln Met Met Cys Ser Lys Thr Cys Tyr Asn Ser Val Asn Ile 
        355                 360                 365             


Ala Phe Leu Ile Asp Gly Ser Ser Ser Val Gly Asp Ser Asn Phe Arg 
    370                 375                 380                 


Leu Met Leu Glu Phe Val Ser Asn Ile Ala Lys Thr Phe Glu Ile Ser 
385                 390                 395                 400 


Asp Ile Gly Ala Lys Ile Ala Ala Val Gln Phe Thr Tyr Asp Gln Arg 
                405                 410                 415     


Thr Glu Phe Ser Phe Thr Asp Tyr Ser Thr Lys Glu Asn Val Leu Ala 
            420                 425                 430         


Val Ile Arg Asn Ile Arg Tyr Met Ser Gly Gly Thr Ala Thr Gly Asp 
        435                 440                 445             


Ala Ile Ser Phe Thr Val Arg Asn Val Phe Gly Pro Ile Arg Glu Ser 
    450                 455                 460                 


Pro Asn Lys Asn Phe Leu Val Ile Val Thr Asp Gly Gln Ser Tyr Asp 
465                 470                 475                 480 


Asp Val Gln Gly Pro Ala Ala Ala Ala His Asp Ala Gly Ile Thr Ile 
                485                 490                 495     


Phe Ser Val Gly Val Ala Trp Ala Pro Leu Asp Asp Leu Lys Asp Met 
            500                 505                 510         


Ala Ser Lys Pro Lys Glu Ser His Ala Phe Phe Thr Arg Glu Phe Thr 
        515                 520                 525             


Gly Leu Glu Pro Ile Val Ser Asp Val Ile Arg Gly Ile Cys Arg Asp 
    530                 535                 540                 


Phe Leu Glu Ser Gln Gln 
545                 550 


<210>  3194
<211>  550
<212>  PRT
<213>  Homo Sapiens

<400>  3194

Met Ser Ala Ala Trp Ile Pro Ala Leu Gly Leu Gly Val Cys Leu Leu 
1               5                   10                  15      


Leu Leu Pro Gly Pro Ala Gly Ser Glu Gly Ala Ala Pro Ile Ala Ile 
            20                  25                  30          


Thr Cys Phe Thr Arg Gly Leu Asp Ile Arg Lys Glu Lys Ala Asp Val 
        35                  40                  45              


Leu Cys Pro Gly Gly Cys Pro Leu Glu Glu Phe Ser Val Tyr Gly Asn 
    50                  55                  60                  


Ile Val Tyr Ala Ser Val Ser Ser Ile Cys Gly Ala Ala Val His Arg 
65                  70                  75                  80  


Gly Val Ile Ser Asn Ser Gly Gly Pro Val Arg Val Tyr Ser Leu Pro 
                85                  90                  95      


Gly Arg Glu Asn Tyr Ser Ser Val Asp Ala Asn Gly Ile Gln Ser Gln 
            100                 105                 110         


Met Leu Ser Arg Trp Ser Ala Ser Phe Thr Val Thr Lys Gly Lys Ser 
        115                 120                 125             


Ser Thr Gln Glu Ala Thr Gly Gln Ala Val Ser Thr Ala His Pro Pro 
    130                 135                 140                 


Thr Gly Lys Arg Leu Lys Lys Thr Pro Glu Lys Lys Thr Gly Asn Lys 
145                 150                 155                 160 


Asp Cys Lys Ala Asp Ile Ala Phe Leu Ile Asp Gly Ser Phe Asn Ile 
                165                 170                 175     


Gly Gln Arg Arg Phe Asn Leu Gln Lys Asn Phe Val Gly Lys Val Ala 
            180                 185                 190         


Leu Met Leu Gly Ile Gly Thr Glu Gly Pro His Val Gly Leu Val Gln 
        195                 200                 205             


Ala Ser Glu His Pro Lys Ile Glu Phe Tyr Leu Lys Asn Phe Thr Ser 
    210                 215                 220                 


Ala Lys Asp Val Leu Phe Ala Ile Lys Glu Val Gly Phe Arg Gly Gly 
225                 230                 235                 240 


Asn Ser Asn Thr Gly Lys Ala Leu Lys His Thr Ala Gln Lys Phe Phe 
                245                 250                 255     


Thr Val Asp Ala Gly Val Arg Lys Gly Ile Pro Lys Val Val Val Val 
            260                 265                 270         


Phe Ile Asp Gly Trp Pro Ser Asp Asp Ile Glu Glu Ala Gly Ile Val 
        275                 280                 285             


Ala Arg Glu Phe Gly Val Asn Val Phe Ile Val Ser Val Ala Lys Pro 
    290                 295                 300                 


Ile Pro Glu Glu Leu Gly Met Val Gln Asp Val Thr Phe Val Asp Lys 
305                 310                 315                 320 


Ala Val Cys Arg Asn Asn Gly Phe Phe Ser Tyr His Met Pro Asn Trp 
                325                 330                 335     


Phe Gly Thr Thr Lys Tyr Val Lys Pro Leu Val Gln Lys Leu Cys Thr 
            340                 345                 350         


His Glu Gln Met Met Cys Ser Lys Thr Cys Tyr Asn Ser Val Asn Ile 
        355                 360                 365             


Ala Phe Leu Ile Asp Gly Ser Ser Ser Val Gly Asp Ser Asn Phe Arg 
    370                 375                 380                 


Leu Met Leu Glu Phe Val Ser Asn Ile Ala Lys Thr Phe Glu Ile Ser 
385                 390                 395                 400 


Asp Ile Gly Ala Lys Ile Ala Ala Val Gln Phe Thr Tyr Asp Gln Arg 
                405                 410                 415     


Thr Glu Phe Ser Phe Thr Asp Tyr Ser Thr Lys Glu Asn Val Leu Ala 
            420                 425                 430         


Val Ile Arg Asn Ile Arg Tyr Met Ser Gly Gly Thr Ala Thr Gly Asp 
        435                 440                 445             


Ala Ile Ser Phe Thr Val Arg Asn Val Phe Gly Pro Ile Arg Glu Ser 
    450                 455                 460                 


Pro Asn Lys Asn Phe Leu Val Ile Val Thr Asp Gly Gln Ser Tyr Asp 
465                 470                 475                 480 


Asp Val Gln Gly Pro Ala Ala Ala Ala His Asp Ala Gly Ile Thr Ile 
                485                 490                 495     


Phe Ser Val Gly Val Ala Trp Ala Pro Leu Asp Asp Leu Lys Asp Met 
            500                 505                 510         


Ala Ser Lys Pro Lys Glu Ser His Ala Phe Phe Thr Arg Glu Phe Thr 
        515                 520                 525             


Gly Leu Glu Pro Ile Val Ser Asp Val Ile Arg Gly Ile Cys Arg Asp 
    530                 535                 540                 


Phe Leu Glu Ser Gln Gln 
545                 550 


<210>  3195
<211>  615
<212>  PRT
<213>  Homo Sapiens

<400>  3195

Met Ser Ala Ala Trp Ile Pro Ala Leu Gly Leu Gly Val Cys Leu Leu 
1               5                   10                  15      


Leu Leu Pro Gly Pro Ala Gly Ser Glu Gly Ala Gly Glu Trp Gly Ser 
            20                  25                  30          


Trp Gly Ala Ser Arg Arg Ser Gln Gly Leu Ser Thr Ser Gly Tyr Lys 
        35                  40                  45              


Arg Asp Ser Asp Pro Ala Pro Trp Ala Ser Ala Leu Pro Pro Glu Glu 
    50                  55                  60                  


Glu Gly Ala Lys Val Glu Pro Pro Arg Gly Ala Pro Ala Leu Thr Pro 
65                  70                  75                  80  


Ala Ala Asp Leu Leu Leu Leu Thr Cys Phe Ser His Ala Pro Ile Ala 
                85                  90                  95      


Ile Thr Cys Phe Thr Arg Gly Leu Asp Ile Arg Lys Glu Lys Ala Asp 
            100                 105                 110         


Val Leu Cys Pro Gly Gly Cys Pro Leu Glu Glu Phe Ser Val Tyr Gly 
        115                 120                 125             


Asn Ile Val Tyr Ala Ser Val Ser Ser Ile Cys Gly Ala Ala Val His 
    130                 135                 140                 


Arg Gly Val Ile Ser Asn Ser Gly Gly Pro Val Arg Val Tyr Ser Leu 
145                 150                 155                 160 


Pro Gly Arg Glu Asn Tyr Ser Ser Val Asp Ala Asn Gly Ile Gln Ser 
                165                 170                 175     


Gln Met Leu Ser Arg Trp Ser Ala Ser Phe Thr Val Thr Lys Gly Lys 
            180                 185                 190         


Ser Ser Thr Gln Glu Ala Thr Gly Gln Ala Val Ser Thr Ala His Pro 
        195                 200                 205             


Pro Thr Gly Lys Arg Leu Lys Lys Thr Pro Glu Lys Lys Thr Gly Asn 
    210                 215                 220                 


Lys Asp Cys Lys Ala Asp Ile Ala Phe Leu Ile Asp Gly Ser Phe Asn 
225                 230                 235                 240 


Ile Gly Gln Arg Arg Phe Asn Leu Gln Lys Asn Phe Val Gly Lys Val 
                245                 250                 255     


Ala Leu Met Leu Gly Ile Gly Thr Glu Gly Pro His Val Gly Leu Val 
            260                 265                 270         


Gln Ala Ser Glu His Pro Lys Ile Glu Phe Tyr Leu Lys Asn Phe Thr 
        275                 280                 285             


Ser Ala Lys Asp Val Leu Phe Ala Ile Lys Glu Val Gly Phe Arg Gly 
    290                 295                 300                 


Gly Asn Ser Asn Thr Gly Lys Ala Leu Lys His Thr Ala Gln Lys Phe 
305                 310                 315                 320 


Phe Thr Val Asp Ala Gly Val Arg Lys Gly Ile Pro Lys Val Val Val 
                325                 330                 335     


Val Phe Ile Asp Gly Trp Pro Ser Asp Asp Ile Glu Glu Ala Gly Ile 
            340                 345                 350         


Val Ala Arg Glu Phe Gly Val Asn Val Phe Ile Val Ser Val Ala Lys 
        355                 360                 365             


Pro Ile Pro Glu Glu Leu Gly Met Val Gln Asp Val Thr Phe Val Asp 
    370                 375                 380                 


Lys Ala Val Cys Arg Asn Asn Gly Phe Phe Ser Tyr His Met Pro Asn 
385                 390                 395                 400 


Trp Phe Gly Thr Thr Lys Tyr Val Lys Pro Leu Val Gln Lys Leu Cys 
                405                 410                 415     


Thr His Glu Gln Met Met Cys Ser Lys Thr Cys Tyr Asn Ser Val Asn 
            420                 425                 430         


Ile Ala Phe Leu Ile Asp Gly Ser Ser Ser Val Gly Asp Ser Asn Phe 
        435                 440                 445             


Arg Leu Met Leu Glu Phe Val Ser Asn Ile Ala Lys Thr Phe Glu Ile 
    450                 455                 460                 


Ser Asp Ile Gly Ala Lys Ile Ala Ala Val Gln Phe Thr Tyr Asp Gln 
465                 470                 475                 480 


Arg Thr Glu Phe Ser Phe Thr Asp Tyr Ser Thr Lys Glu Asn Val Leu 
                485                 490                 495     


Ala Val Ile Arg Asn Ile Arg Tyr Met Ser Gly Gly Thr Ala Thr Gly 
            500                 505                 510         


Asp Ala Ile Ser Phe Thr Val Arg Asn Val Phe Gly Pro Ile Arg Glu 
        515                 520                 525             


Ser Pro Asn Lys Asn Phe Leu Val Ile Val Thr Asp Gly Gln Ser Tyr 
    530                 535                 540                 


Asp Asp Val Gln Gly Pro Ala Ala Ala Ala His Asp Ala Gly Ile Thr 
545                 550                 555                 560 


Ile Phe Ser Val Gly Val Ala Trp Ala Pro Leu Asp Asp Leu Lys Asp 
                565                 570                 575     


Met Ala Ser Lys Pro Lys Glu Ser His Ala Phe Phe Thr Arg Glu Phe 
            580                 585                 590         


Thr Gly Leu Glu Pro Ile Val Ser Asp Val Ile Arg Gly Ile Cys Arg 
        595                 600                 605             


Asp Phe Leu Glu Ser Gln Gln 
    610                 615 


<210>  3196
<211>  202
<212>  PRT
<213>  Homo Sapiens

<400>  3196

Met Ser Ala Ala Trp Ile Pro Ala Leu Gly Leu Gly Val Cys Leu Leu 
1               5                   10                  15      


Leu Leu Pro Gly Pro Ala Gly Ser Glu Gly Ala Gly Lys Arg Leu Lys 
            20                  25                  30          


Lys Thr Pro Glu Lys Lys Thr Gly Asn Lys Asp Cys Lys Ala Asp Ile 
        35                  40                  45              


Ala Phe Leu Ile Asp Gly Ser Phe Asn Ile Gly Gln Arg Arg Phe Asn 
    50                  55                  60                  


Leu Gln Lys Asn Phe Val Gly Lys Val Ala Leu Met Leu Gly Ile Gly 
65                  70                  75                  80  


Thr Glu Gly Pro His Val Gly Leu Val Gln Ala Ser Glu His Pro Lys 
                85                  90                  95      


Ile Glu Phe Tyr Leu Lys Asn Phe Thr Ser Ala Lys Asp Val Leu Phe 
            100                 105                 110         


Ala Ile Lys Glu Val Gly Phe Arg Gly Gly Asn Ser Asn Thr Gly Lys 
        115                 120                 125             


Ala Leu Lys His Thr Ala Gln Lys Phe Phe Thr Val Asp Ala Gly Val 
    130                 135                 140                 


Arg Lys Gly Ile Pro Lys Val Val Val Val Phe Ile Asp Gly Trp Pro 
145                 150                 155                 160 


Ser Asp Asp Ile Glu Glu Ala Gly Ile Val Ala Arg Glu Phe Gly Val 
                165                 170                 175     


Asn Val Phe Ile Val Ser Val Ala Lys Pro Ile Pro Glu Glu Leu Gly 
            180                 185                 190         


Met Val Gln Asp Val Thr Phe Val Asp Lys 
        195                 200         


<210>  3197
<211>  55
<212>  PRT
<213>  Homo Sapiens

<400>  3197

Pro Ile Ala Ile Thr Cys Phe Thr Arg Gly Leu Asp Ile Arg Lys Glu 
1               5                   10                  15      


Lys Ala Asp Val Leu Cys Pro Gly Gly Cys Pro Leu Glu Glu Phe Ser 
            20                  25                  30          


Val Tyr Gly Asn Ile Val Tyr Ala Ser Val Ser Ser Ile Cys Gly Ala 
        35                  40                  45              


Ala Val His Arg Arg Gln Lys 
    50                  55  


<210>  3198
<211>  434
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3198

Xaa Cys Lys Ala Asp Ile Ala Phe Leu Ile Asp Gly Ser Phe Asn Ile 
1               5                   10                  15      


Gly Gln Arg Arg Phe Asn Leu Gln Lys Asn Phe Val Gly Lys Val Ala 
            20                  25                  30          


Leu Met Leu Gly Ile Gly Thr Glu Gly Pro His Val Gly Leu Val Gln 
        35                  40                  45              


Ala Ser Glu His Pro Lys Ile Glu Phe Tyr Leu Lys Asn Phe Thr Ser 
    50                  55                  60                  


Ala Lys Asp Val Leu Phe Ala Ile Lys Glu Val Gly Phe Arg Gly Gly 
65                  70                  75                  80  


Asn Ser Asn Thr Asp Ile Thr Leu Glu Lys Tyr Leu Phe Val Met Leu 
                85                  90                  95      


Lys Arg Ser Glu Asn Gln Gln Thr Tyr Leu Met Asn Ala Asp Val Ala 
            100                 105                 110         


Glu Arg Met Ser Ser Thr Thr Val Asp Ser Glu Glu Arg Leu Leu Arg 
        115                 120                 125             


Gly Lys Ala Leu Lys His Thr Ala Gln Lys Phe Phe Thr Val Asp Ala 
    130                 135                 140                 


Gly Val Arg Lys Gly Ile Pro Lys Val Val Val Val Phe Ile Asp Gly 
145                 150                 155                 160 


Trp Pro Ser Asp Asp Ile Glu Glu Ala Gly Ile Val Ala Arg Glu Phe 
                165                 170                 175     


Gly Val Asn Val Phe Ile Val Ser Val Ala Lys Pro Ile Pro Glu Glu 
            180                 185                 190         


Leu Gly Met Val Gln Asp Val Thr Phe Val Asp Lys Ala Val Cys Arg 
        195                 200                 205             


Asn Asn Gly Phe Phe Ser Tyr His Met Pro Asn Trp Phe Gly Thr Thr 
    210                 215                 220                 


Lys Tyr Val Lys Pro Leu Val Gln Lys Leu Cys Thr His Glu Gln Met 
225                 230                 235                 240 


Met Cys Ser Lys Thr Cys Tyr Asn Ser Val Asn Ile Ala Phe Leu Ile 
                245                 250                 255     


Asp Gly Ser Ser Ser Val Gly Asp Ser Asn Phe Arg Leu Met Leu Glu 
            260                 265                 270         


Phe Val Ser Asn Ile Ala Lys Thr Phe Glu Ile Ser Asp Ile Gly Ala 
        275                 280                 285             


Lys Ile Ala Ala Val Gln Phe Thr Tyr Asp Gln Arg Thr Glu Phe Ser 
    290                 295                 300                 


Phe Thr Asp Tyr Ser Thr Lys Glu Asn Val Leu Ala Val Ile Arg Asn 
305                 310                 315                 320 


Ile Arg Tyr Met Ser Gly Gly Thr Ala Thr Gly Asp Ala Ile Ser Phe 
                325                 330                 335     


Thr Val Arg Asn Val Phe Gly Pro Ile Arg Glu Ser Pro Asn Lys Asn 
            340                 345                 350         


Phe Leu Val Ile Val Thr Asp Gly Gln Ser Tyr Asp Asp Val Gln Gly 
        355                 360                 365             


Pro Ala Ala Ala Ala His Asp Ala Gly Ile Thr Ile Phe Ser Val Gly 
    370                 375                 380                 


Val Ala Trp Ala Pro Leu Asp Asp Leu Lys Asp Met Ala Ser Lys Pro 
385                 390                 395                 400 


Lys Glu Ser His Ala Phe Phe Thr Arg Glu Phe Thr Gly Leu Glu Pro 
                405                 410                 415     


Ile Val Ser Asp Val Ile Arg Gly Ile Cys Arg Asp Phe Leu Glu Ser 
            420                 425                 430         


Gln Gln 
        


<210>  3199
<211>  828
<212>  PRT
<213>  Homo Sapiens

<400>  3199

Met Ala Glu Ala Ala Leu Leu Leu Leu Pro Glu Ala Ala Ala Glu Arg 
1               5                   10                  15      


Asp Ala Arg Glu Lys Leu Ala Leu Trp Asp Arg Arg Pro Asp Thr Thr 
            20                  25                  30          


Ala Pro Leu Thr Asp Arg Gln Thr Asp Ser Val Leu Glu Leu Lys Ala 
        35                  40                  45              


Ala Ala Glu Asn Leu Pro Val Pro Ala Glu Leu Pro Ile Glu Asp Leu 
    50                  55                  60                  


Cys Ser Leu Thr Ser Gln Ser Leu Pro Ile Glu Leu Thr Ser Val Val 
65                  70                  75                  80  


Pro Glu Ser Thr Glu Asp Ile Leu Leu Lys Gly Phe Thr Ser Leu Gly 
                85                  90                  95      


Met Glu Glu Glu Arg Ile Glu Thr Ala Gln Gln Phe Phe Ser Trp Phe 
            100                 105                 110         


Ala Lys Leu Gln Thr Gln Met Asp Gln Asp Glu Gly Thr Lys Tyr Arg 
        115                 120                 125             


Gln Met Arg Asp Tyr Leu Ser Gly Phe Gln Glu Gln Cys Asp Ala Ile 
    130                 135                 140                 


Leu Asn Asp Val Asn Ser Ala Leu Gln His Leu Glu Ser Leu Gln Lys 
145                 150                 155                 160 


Gln Tyr Leu Phe Val Ser Asn Lys Thr Gly Thr Leu His Glu Ala Cys 
                165                 170                 175     


Glu Gln Leu Leu Lys Glu Gln Ser Glu Leu Val Asp Leu Ala Glu Asn 
            180                 185                 190         


Ile Gln Gln Lys Leu Ser Tyr Phe Asn Glu Leu Glu Thr Ile Asn Thr 
        195                 200                 205             


Lys Leu Asn Ser Pro Thr Leu Ser Val Asn Ser Asp Gly Phe Ile Pro 
    210                 215                 220                 


Met Leu Ala Lys Leu Asp Asp Cys Ile Thr Tyr Ile Ser Ser His Pro 
225                 230                 235                 240 


Asn Phe Lys Asp Tyr Pro Ile Tyr Leu Leu Lys Phe Lys Gln Cys Leu 
                245                 250                 255     


Ser Lys Ala Leu His Leu Met Lys Thr Tyr Thr Val Asn Thr Leu Gln 
            260                 265                 270         


Thr Leu Thr Ser Gln Leu Leu Lys Arg Asp Pro Ser Ser Val Pro Asn 
        275                 280                 285             


Ala Asp Asn Ala Phe Thr Leu Phe Tyr Val Lys Phe Arg Ala Ala Ala 
    290                 295                 300                 


Pro Lys Val Arg Thr Leu Ile Glu Gln Ile Glu Leu Arg Ser Glu Lys 
305                 310                 315                 320 


Ile Pro Glu Tyr Gln Gln Leu Leu Asn Asp Ile His Gln Cys Tyr Leu 
                325                 330                 335     


Asp Gln Arg Glu Leu Leu Leu Gly Pro Ser Ile Ala Cys Thr Val Ala 
            340                 345                 350         


Glu Leu Thr Ser Gln Asn Asn Arg Asp His Cys Ala Leu Val Arg Ser 
        355                 360                 365             


Gly Cys Ala Phe Met Val His Val Cys Gln Asp Glu His Gln Leu Tyr 
    370                 375                 380                 


Asn Glu Phe Phe Thr Lys Pro Thr Ser Lys Leu Asp Glu Leu Leu Glu 
385                 390                 395                 400 


Lys Leu Cys Val Ser Leu Tyr Asp Val Phe Arg Pro Leu Ile Ile His 
                405                 410                 415     


Val Ile His Leu Glu Thr Leu Ser Glu Leu Cys Gly Ile Leu Lys Asn 
            420                 425                 430         


Glu Val Leu Glu Asp His Val Gln Asn Asn Ala Glu Gln Leu Gly Ala 
        435                 440                 445             


Phe Ala Ala Gly Val Lys Gln Met Leu Glu Asp Val Gln Glu Arg Leu 
    450                 455                 460                 


Val Tyr Arg Thr His Ile Tyr Ile Gln Thr Asp Ile Thr Gly Tyr Lys 
465                 470                 475                 480 


Pro Ala Pro Gly Asp Leu Ala Tyr Pro Asp Lys Leu Val Met Met Glu 
                485                 490                 495     


Gln Ile Ala Gln Ser Leu Lys Asp Glu Gln Lys Lys Val Pro Ser Glu 
            500                 505                 510         


Ala Ser Phe Ser Asp Val His Leu Glu Glu Gly Glu Ser Asn Ser Leu 
        515                 520                 525             


Thr Lys Ser Gly Ser Thr Glu Ser Leu Asn Pro Arg Pro Gln Thr Thr 
    530                 535                 540                 


Ile Ser Pro Ala Asp Leu His Gly Met Trp Tyr Pro Thr Val Arg Arg 
545                 550                 555                 560 


Thr Leu Val Cys Leu Ser Lys Leu Tyr Arg Cys Ile Asp Arg Ala Val 
                565                 570                 575     


Phe Gln Gly Leu Ser Gln Glu Ala Leu Ser Ala Cys Ile Gln Ser Leu 
            580                 585                 590         


Leu Gly Ala Ser Glu Ser Ile Ser Lys Asn Lys Thr Gln Ile Asp Gly 
        595                 600                 605             


Gln Leu Phe Leu Ile Lys His Leu Leu Ile Leu Arg Glu Gln Ile Ala 
    610                 615                 620                 


Pro Phe His Thr Glu Phe Thr Ile Lys Glu Ile Ser Leu Asp Leu Lys 
625                 630                 635                 640 


Lys Thr Arg Asp Ala Ala Phe Lys Ile Leu Asn Pro Met Thr Val Pro 
                645                 650                 655     


Arg Phe Phe Arg Leu Asn Ser Asn Asn Ala Leu Ile Glu Phe Leu Leu 
            660                 665                 670         


Glu Gly Thr Pro Glu Ile Arg Glu His Tyr Leu Asp Ser Lys Lys Asp 
        675                 680                 685             


Val Asp Arg His Leu Lys Ser Ala Cys Glu Gln Phe Ile Gln Gln Gln 
    690                 695                 700                 


Thr Lys Leu Phe Val Glu Gln Leu Glu Glu Phe Met Thr Lys Val Ser 
705                 710                 715                 720 


Ala Leu Lys Thr Met Ala Ser Gln Gly Gly Pro Lys Tyr Thr Leu Ser 
                725                 730                 735     


Gln Gln Pro Trp Ala Gln Pro Ala Lys Val Asn Asp Leu Ala Ala Thr 
            740                 745                 750         


Ala Tyr Lys Thr Ile Lys Thr Lys Leu Pro Val Thr Leu Arg Ser Met 
        755                 760                 765             


Ser Leu Tyr Leu Ser Asn Lys Asp Thr Glu Phe Ile Leu Phe Lys Pro 
    770                 775                 780                 


Val Arg Asn Asn Ile Gln Gln Val Phe Gln Lys Phe His Ala Leu Leu 
785                 790                 795                 800 


Lys Glu Glu Phe Ser Pro Glu Asp Ile Gln Ile Ile Ala Cys Pro Ser 
                805                 810                 815     


Met Glu Gln Leu Ser Leu Leu Leu Leu Val Ser Lys 
            820                 825             


<210>  3200
<211>  444
<212>  PRT
<213>  Homo Sapiens

<400>  3200

Met Ala Glu Ala Ala Leu Leu Leu Leu Pro Glu Ala Ala Ala Glu Arg 
1               5                   10                  15      


Asp Ala Arg Glu Lys Leu Ala Leu Trp Asp Arg Arg Pro Asp Thr Thr 
            20                  25                  30          


Ala Pro Leu Thr Asp Arg Gln Thr Asp Ser Val Leu Glu Leu Lys Ala 
        35                  40                  45              


Ala Ala Glu Asn Leu Pro Val Pro Ala Glu Leu Pro Ile Glu Asp Leu 
    50                  55                  60                  


Cys Ser Leu Thr Ser Gln Ser Leu Pro Ile Glu Leu Thr Ser Val Val 
65                  70                  75                  80  


Pro Glu Ser Thr Glu Asp Ile Leu Leu Lys Gly Phe Thr Ser Leu Gly 
                85                  90                  95      


Met Glu Glu Glu Arg Ile Glu Thr Ala Gln Gln Phe Phe Ser Trp Phe 
            100                 105                 110         


Ala Lys Leu Gln Thr Gln Met Asp Gln Asp Glu Gly Thr Lys Tyr Arg 
        115                 120                 125             


Gln Met Arg Asp Tyr Leu Ser Gly Phe Gln Glu Gln Cys Asp Ala Ile 
    130                 135                 140                 


Leu Asn Asp Val Asn Ser Ala Leu Gln His Leu Glu Ser Leu Gln Lys 
145                 150                 155                 160 


Gln Tyr Leu Phe Val Ser Asn Lys Thr Gly Thr Leu His Glu Ala Cys 
                165                 170                 175     


Glu Gln Leu Leu Lys Glu Gln Ser Glu Leu Val Asp Leu Ala Glu Asn 
            180                 185                 190         


Ile Gln Gln Lys Leu Ser Tyr Phe Asn Glu Leu Glu Thr Ile Asn Thr 
        195                 200                 205             


Lys Leu Asn Ser Pro Thr Leu Ser Val Asn Ser Asp Gly Phe Ile Pro 
    210                 215                 220                 


Met Leu Ala Lys Leu Asp Asp Cys Ile Thr Tyr Ile Ser Ser His Pro 
225                 230                 235                 240 


Asn Phe Lys Asp Tyr Pro Ile Tyr Leu Leu Lys Phe Lys Gln Cys Leu 
                245                 250                 255     


Ser Lys Ala Leu His Leu Met Lys Thr Tyr Thr Val Asn Thr Leu Gln 
            260                 265                 270         


Thr Leu Thr Ser Gln Leu Leu Lys Arg Asp Pro Ser Ser Val Pro Asn 
        275                 280                 285             


Ala Asp Asn Ala Phe Thr Leu Phe Tyr Val Lys Phe Arg Ala Ala Ala 
    290                 295                 300                 


Pro Lys Val Arg Thr Leu Ile Glu Gln Ile Glu Leu Arg Ser Glu Lys 
305                 310                 315                 320 


Ile Pro Glu Tyr Gln Gln Leu Leu Asn Asp Ile His Gln Cys Tyr Leu 
                325                 330                 335     


Asp Gln Arg Glu Leu Leu Leu Gly Pro Ser Ile Ala Cys Thr Val Ala 
            340                 345                 350         


Glu Leu Thr Ser Gln Asn Asn Arg Asp His Cys Ala Leu Val Arg Ser 
        355                 360                 365             


Gly Cys Ala Phe Met Val His Val Cys Gln Asp Glu His Gln Leu Tyr 
    370                 375                 380                 


Asn Glu Phe Phe Thr Lys Pro Thr Ser Lys Leu Asp Glu Leu Leu Glu 
385                 390                 395                 400 


Lys Leu Cys Val Ser Leu Tyr Asp Val Phe Arg Pro Leu Ile Ile His 
                405                 410                 415     


Val Ile His Leu Glu Thr Leu Ser Glu Leu Cys Gly Ile Leu Lys Asn 
            420                 425                 430         


Glu Val Leu Glu Asp His Val Gln Asn Asn Gly Lys 
        435                 440                 


<210>  3201
<211>  85
<212>  PRT
<213>  Homo Sapiens

<400>  3201

Pro Glu Ala Ala Ala Glu Arg Asp Ala Arg Glu Lys Leu Ala Leu Trp 
1               5                   10                  15      


Asp Arg Arg Pro Asp Thr Thr Ala Pro Leu Thr Asp Arg Gln Thr Asp 
            20                  25                  30          


Ser Val Leu Glu Leu Lys Ala Ala Ala Glu Asn Leu Pro Val Pro Ala 
        35                  40                  45              


Glu Asp Met Val Pro Glu Val Asp Leu Lys Ser Met Lys Ala Gln Val 
    50                  55                  60                  


Glu Ile Ser Leu Ala Gln Leu Ser Asn Ser Phe Ile Pro Trp Ile Ile 
65                  70                  75                  80  


Lys Val Val Cys Ser 
                85  


<210>  3202
<211>  68
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3202

Xaa Ile Asp Gly Gln Leu Phe Leu Ile Lys His Leu Leu Ile Leu Arg 
1               5                   10                  15      


Glu Gln Ile Ala Pro Phe His Thr Glu Phe Thr Ile Lys Glu Ile Ser 
            20                  25                  30          


Leu Asp Leu Lys Lys Thr Arg Gly Phe Ser Val Lys Asn Asn Gly Gln 
        35                  40                  45              


Ser Gly Arg Pro Gln Val Tyr Ser Leu Thr Ala Ala Leu Gly Thr Thr 
    50                  55                  60                  


Ser Lys Gly Gln 
65              


<210>  3203
<211>  51
<212>  PRT
<213>  Homo Sapiens

<400>  3203

Met Leu Pro Gln Ile Pro Phe Leu Leu Leu Val Ser Leu Asn Leu Val 
1               5                   10                  15      


His Gly Val Phe Tyr Ala Glu Arg Tyr Gln Met Pro Thr Gly Ile Lys 
            20                  25                  30          


Gly Pro Leu Pro Asn Thr Lys Thr Gln Phe Phe Ile Pro Tyr Thr Ile 
        35                  40                  45              


Lys Ser Lys 
    50      


<210>  3204
<211>  216
<212>  PRT
<213>  Homo Sapiens

<400>  3204

Met Leu Pro Gln Ile Pro Phe Leu Leu Leu Val Ser Leu Asn Leu Val 
1               5                   10                  15      


His Gly Val Phe Tyr Ala Glu Arg Tyr Gln Met Pro Thr Gly Ile Lys 
            20                  25                  30          


Gly Pro Leu Pro Asn Thr Lys Thr Gln Phe Phe Ile Pro Tyr Thr Ile 
        35                  40                  45              


Lys Ser Lys Gly Ile Ala Val Arg Gly Glu Gln Gly Thr Pro Gly Pro 
    50                  55                  60                  


Pro Gly Pro Ala Gly Pro Arg Gly His Pro Gly Pro Ser Gly Pro Pro 
65                  70                  75                  80  


Gly Lys Pro Gly Tyr Gly Ser Pro Gly Leu Gln Gly Glu Pro Gly Leu 
                85                  90                  95      


Pro Gly Pro Pro Gly Pro Ser Ala Val Gly Lys Pro Gly Val Pro Gly 
            100                 105                 110         


Leu Pro Gly Lys Pro Gly Glu Arg Gly Pro Tyr Gly Pro Lys Gly Asp 
        115                 120                 125             


Val Gly Pro Ala Gly Leu Pro Gly Pro Arg Gly Pro Pro Gly Pro Pro 
    130                 135                 140                 


Gly Ile Pro Gly Pro Ala Gly Ile Ser Val Pro Gly Lys Pro Gly Gln 
145                 150                 155                 160 


Gln Gly Pro Thr Gly Ala Pro Gly Pro Arg Gly Phe Pro Gly Glu Lys 
                165                 170                 175     


Gly Ala Pro Gly Val Pro Gly Met Asn Gly Gln Lys Gly Glu Met Gly 
            180                 185                 190         


Tyr Gly Ala Pro Gly Arg Pro Gly Glu Arg Gly Leu Pro Gly Pro Gln 
        195                 200                 205             


Gly Pro Thr Gly Pro Ser Gly Pro 
    210                 215     


<210>  3205
<211>  680
<212>  PRT
<213>  Homo Sapiens

<400>  3205

Met Leu Pro Gln Ile Pro Phe Leu Leu Leu Val Ser Leu Asn Leu Val 
1               5                   10                  15      


His Gly Val Phe Tyr Ala Glu Arg Tyr Gln Met Pro Thr Gly Ile Lys 
            20                  25                  30          


Gly Pro Leu Pro Asn Thr Lys Thr Gln Phe Phe Ile Pro Tyr Thr Ile 
        35                  40                  45              


Lys Ser Lys Gly Ile Ala Val Arg Gly Glu Gln Gly Thr Pro Gly Pro 
    50                  55                  60                  


Pro Gly Pro Ala Gly Pro Arg Gly His Pro Gly Pro Ser Gly Pro Pro 
65                  70                  75                  80  


Gly Lys Pro Gly Tyr Gly Ser Pro Gly Leu Gln Gly Glu Pro Gly Leu 
                85                  90                  95      


Pro Gly Pro Pro Gly Pro Ser Ala Val Gly Lys Pro Gly Val Pro Gly 
            100                 105                 110         


Leu Pro Gly Lys Pro Gly Glu Arg Gly Pro Tyr Gly Pro Lys Gly Asp 
        115                 120                 125             


Val Gly Pro Ala Gly Leu Pro Gly Pro Arg Gly Pro Pro Gly Pro Pro 
    130                 135                 140                 


Gly Ile Pro Gly Pro Ala Gly Ile Ser Val Pro Gly Lys Pro Gly Gln 
145                 150                 155                 160 


Gln Gly Pro Thr Gly Ala Pro Gly Pro Arg Gly Phe Pro Gly Glu Lys 
                165                 170                 175     


Gly Ala Pro Gly Val Pro Gly Met Asn Gly Gln Lys Gly Glu Met Gly 
            180                 185                 190         


Tyr Gly Ala Pro Gly Arg Pro Gly Glu Arg Gly Leu Pro Gly Pro Gln 
        195                 200                 205             


Gly Pro Thr Gly Pro Ser Gly Pro Pro Gly Val Gly Lys Arg Gly Glu 
    210                 215                 220                 


Asn Gly Val Pro Gly Gln Pro Gly Ile Lys Gly Asp Arg Gly Phe Pro 
225                 230                 235                 240 


Gly Glu Met Gly Pro Ile Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly 
                245                 250                 255     


Glu Arg Gly Pro Glu Gly Ile Gly Lys Pro Gly Ala Ala Gly Ala Pro 
            260                 265                 270         


Gly Gln Pro Gly Ile Pro Gly Thr Lys Gly Leu Pro Gly Ala Pro Gly 
        275                 280                 285             


Ile Ala Gly Pro Pro Gly Pro Pro Gly Phe Gly Lys Pro Gly Leu Pro 
    290                 295                 300                 


Gly Leu Lys Gly Glu Arg Gly Pro Ala Gly Leu Pro Gly Gly Pro Gly 
305                 310                 315                 320 


Ala Lys Gly Glu Gln Gly Pro Ala Gly Leu Pro Gly Lys Pro Gly Leu 
                325                 330                 335     


Thr Gly Pro Pro Gly Asn Met Gly Pro Gln Gly Pro Lys Gly Ile Pro 
            340                 345                 350         


Gly Ser His Gly Leu Pro Gly Pro Lys Gly Glu Thr Gly Pro Ala Gly 
        355                 360                 365             


Pro Ala Gly Tyr Pro Gly Ala Lys Gly Glu Arg Gly Ser Pro Gly Ser 
    370                 375                 380                 


Asp Gly Lys Pro Gly Tyr Pro Gly Lys Pro Gly Leu Asp Gly Pro Lys 
385                 390                 395                 400 


Gly Asn Pro Gly Leu Pro Gly Pro Lys Gly Asp Pro Gly Val Gly Gly 
                405                 410                 415     


Pro Pro Gly Leu Pro Gly Pro Val Gly Pro Ala Gly Ala Lys Gly Met 
            420                 425                 430         


Pro Gly His Asn Gly Glu Ala Gly Pro Arg Gly Ala Pro Gly Ile Pro 
        435                 440                 445             


Gly Thr Arg Gly Pro Ile Gly Pro Pro Gly Ile Pro Gly Phe Pro Gly 
    450                 455                 460                 


Ser Lys Gly Asp Pro Gly Ser Pro Gly Pro Pro Gly Pro Ala Gly Ile 
465                 470                 475                 480 


Ala Thr Lys Gly Leu Asn Gly Pro Thr Gly Pro Pro Gly Pro Pro Gly 
                485                 490                 495     


Pro Arg Gly His Ser Gly Glu Pro Gly Leu Pro Gly Pro Pro Gly Pro 
            500                 505                 510         


Pro Gly Pro Pro Gly Gln Ala Val Met Pro Glu Gly Phe Ile Lys Ala 
        515                 520                 525             


Gly Gln Arg Pro Ser Leu Ser Gly Thr Pro Leu Val Ser Ala Asn Gln 
    530                 535                 540                 


Gly Val Thr Gly Met Pro Val Ser Ala Phe Thr Val Ile Leu Ser Lys 
545                 550                 555                 560 


Ala Tyr Pro Ala Ile Gly Thr Pro Ile Pro Phe Asp Lys Ile Leu Tyr 
                565                 570                 575     


Asn Arg Gln Gln His Tyr Asp Pro Arg Thr Gly Ile Phe Thr Cys Gln 
            580                 585                 590         


Ile Pro Gly Ile Tyr Tyr Phe Ser Tyr His Val His Val Lys Gly Thr 
        595                 600                 605             


His Val Trp Val Gly Leu Tyr Lys Asn Gly Thr Pro Val Met Tyr Thr 
    610                 615                 620                 


Tyr Asp Glu Tyr Thr Lys Gly Tyr Leu Asp Gln Ala Ser Gly Ser Ala 
625                 630                 635                 640 


Ile Ile Asp Leu Thr Glu Asn Asp Gln Val Trp Leu Gln Leu Pro Asn 
                645                 650                 655     


Ala Glu Ser Asn Gly Leu Tyr Ser Ser Glu Tyr Val His Ser Ser Phe 
            660                 665                 670         


Ser Gly Phe Leu Val Ala Pro Met 
        675                 680 


<210>  3206
<211>  680
<212>  PRT
<213>  Homo Sapiens

<400>  3206

Met Leu Pro Gln Ile Pro Phe Leu Leu Leu Val Ser Leu Asn Leu Val 
1               5                   10                  15      


His Gly Val Phe Tyr Ala Glu Arg Tyr Gln Met Pro Thr Gly Ile Lys 
            20                  25                  30          


Gly Pro Leu Pro Asn Thr Lys Thr Gln Phe Phe Ile Pro Tyr Thr Ile 
        35                  40                  45              


Lys Ser Lys Gly Ile Ala Val Arg Gly Glu Gln Gly Thr Pro Gly Pro 
    50                  55                  60                  


Pro Gly Pro Ala Gly Pro Arg Gly His Pro Gly Pro Ser Gly Pro Pro 
65                  70                  75                  80  


Gly Lys Pro Gly Tyr Gly Ser Pro Gly Leu Gln Gly Glu Pro Gly Leu 
                85                  90                  95      


Pro Gly Pro Pro Gly Pro Ser Ala Val Gly Lys Pro Gly Val Pro Gly 
            100                 105                 110         


Leu Pro Gly Lys Pro Gly Glu Arg Gly Pro Tyr Gly Pro Lys Gly Asp 
        115                 120                 125             


Val Gly Pro Ala Gly Leu Pro Gly Pro Arg Gly Pro Pro Gly Pro Pro 
    130                 135                 140                 


Gly Ile Pro Gly Pro Ala Gly Ile Ser Val Pro Gly Lys Pro Gly Gln 
145                 150                 155                 160 


Gln Gly Pro Thr Gly Ala Pro Gly Pro Arg Gly Phe Pro Gly Glu Lys 
                165                 170                 175     


Gly Ala Pro Gly Val Pro Gly Met Asn Gly Gln Lys Gly Glu Met Gly 
            180                 185                 190         


Tyr Gly Ala Pro Gly Arg Pro Gly Glu Arg Gly Leu Pro Gly Pro Gln 
        195                 200                 205             


Gly Pro Thr Gly Pro Ser Gly Pro Pro Gly Val Gly Lys Arg Gly Glu 
    210                 215                 220                 


Asn Gly Val Pro Gly Gln Pro Gly Ile Lys Gly Asp Arg Gly Phe Pro 
225                 230                 235                 240 


Gly Glu Met Gly Pro Ile Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly 
                245                 250                 255     


Glu Arg Gly Pro Glu Gly Ile Gly Lys Pro Gly Ala Ala Gly Ala Pro 
            260                 265                 270         


Gly Gln Pro Gly Ile Pro Gly Thr Lys Gly Leu Pro Gly Ala Pro Gly 
        275                 280                 285             


Ile Ala Gly Pro Pro Gly Pro Pro Gly Phe Gly Lys Pro Gly Leu Pro 
    290                 295                 300                 


Gly Leu Lys Gly Glu Arg Gly Pro Ala Gly Leu Pro Gly Gly Pro Gly 
305                 310                 315                 320 


Ala Lys Gly Glu Gln Gly Pro Ala Gly Leu Pro Gly Lys Pro Gly Leu 
                325                 330                 335     


Thr Gly Pro Pro Gly Asn Met Gly Pro Gln Gly Pro Lys Gly Ile Pro 
            340                 345                 350         


Gly Ser His Gly Leu Pro Gly Pro Lys Gly Glu Thr Gly Pro Ala Gly 
        355                 360                 365             


Pro Ala Gly Tyr Pro Gly Ala Lys Gly Glu Arg Gly Ser Pro Gly Ser 
    370                 375                 380                 


Asp Gly Lys Pro Gly Tyr Pro Gly Lys Pro Gly Leu Asp Gly Pro Lys 
385                 390                 395                 400 


Gly Asn Pro Gly Leu Pro Gly Pro Lys Gly Asp Pro Gly Val Gly Gly 
                405                 410                 415     


Pro Pro Gly Leu Pro Gly Pro Val Gly Pro Ala Gly Ala Lys Gly Met 
            420                 425                 430         


Pro Gly His Asn Gly Glu Ala Gly Pro Arg Gly Ala Pro Gly Ile Pro 
        435                 440                 445             


Gly Thr Arg Gly Pro Ile Gly Pro Pro Gly Ile Pro Gly Phe Pro Gly 
    450                 455                 460                 


Ser Lys Gly Asp Pro Gly Ser Pro Gly Pro Pro Gly Pro Ala Gly Ile 
465                 470                 475                 480 


Ala Thr Lys Gly Leu Asn Gly Pro Thr Gly Pro Pro Gly Pro Pro Gly 
                485                 490                 495     


Pro Arg Gly His Ser Gly Glu Pro Gly Leu Pro Gly Pro Pro Gly Pro 
            500                 505                 510         


Pro Gly Pro Pro Gly Gln Ala Val Met Pro Glu Gly Phe Ile Lys Ala 
        515                 520                 525             


Gly Gln Arg Pro Ser Leu Ser Gly Thr Pro Leu Val Ser Ala Asn Gln 
    530                 535                 540                 


Gly Val Thr Gly Met Pro Val Ser Ala Phe Thr Val Ile Leu Ser Lys 
545                 550                 555                 560 


Ala Tyr Pro Ala Ile Gly Thr Pro Ile Pro Phe Asp Lys Ile Leu Tyr 
                565                 570                 575     


Asn Arg Gln Gln His Tyr Asp Pro Arg Thr Gly Ile Phe Thr Cys Gln 
            580                 585                 590         


Ile Pro Gly Ile Tyr Tyr Phe Ser Tyr His Val His Val Lys Gly Thr 
        595                 600                 605             


His Val Trp Val Gly Leu Tyr Lys Asn Gly Thr Pro Val Met Tyr Thr 
    610                 615                 620                 


Tyr Asp Glu Tyr Thr Lys Gly Tyr Leu Asp Gln Ala Ser Gly Ser Ala 
625                 630                 635                 640 


Ile Ile Asp Leu Thr Glu Asn Asp Gln Val Trp Leu Gln Leu Pro Asn 
                645                 650                 655     


Ala Glu Ser Asn Gly Leu Tyr Ser Ser Glu Tyr Val His Ser Ser Phe 
            660                 665                 670         


Ser Gly Phe Leu Val Ala Pro Met 
        675                 680 


<210>  3207
<211>  1767
<212>  PRT
<213>  Homo Sapiens

<400>  3207

Met Glu Pro Trp Ser Ser Arg Trp Lys Thr Lys Arg Trp Leu Trp Asp 
1               5                   10                  15      


Phe Thr Val Thr Thr Leu Ala Leu Thr Phe Leu Phe Gln Ala Arg Glu 
            20                  25                  30          


Val Arg Gly Ala Ala Pro Val Asp Val Leu Lys Ala Leu Asp Phe His 
        35                  40                  45              


Asn Ser Pro Glu Gly Ile Ser Lys Thr Thr Gly Phe Cys Thr Asn Arg 
    50                  55                  60                  


Lys Asn Ser Lys Gly Ser Asp Thr Ala Tyr Arg Val Ser Lys Gln Ala 
65                  70                  75                  80  


Gln Leu Ser Ala Pro Thr Lys Gln Leu Phe Pro Gly Gly Thr Phe Pro 
                85                  90                  95      


Glu Asp Phe Ser Ile Leu Phe Thr Val Lys Pro Lys Lys Gly Ile Gln 
            100                 105                 110         


Ser Phe Leu Leu Ser Ile Tyr Asn Glu His Gly Ile Gln Gln Ile Gly 
        115                 120                 125             


Val Glu Val Gly Arg Ser Pro Val Phe Leu Phe Glu Asp His Thr Gly 
    130                 135                 140                 


Lys Pro Ala Pro Glu Asp Tyr Pro Leu Phe Arg Thr Val Asn Ile Ala 
145                 150                 155                 160 


Asp Gly Lys Trp His Arg Val Ala Ile Ser Val Glu Lys Lys Thr Val 
                165                 170                 175     


Thr Met Ile Val Asp Cys Lys Lys Lys Thr Thr Lys Pro Leu Asp Arg 
            180                 185                 190         


Ser Glu Arg Ala Ile Val Asp Thr Asn Gly Ile Thr Val Phe Gly Thr 
        195                 200                 205             


Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Ile Gln Gln Phe Leu 
    210                 215                 220                 


Ile Thr Gly Asp Pro Lys Ala Ala Tyr Asp Tyr Cys Glu His Tyr Ser 
225                 230                 235                 240 


Pro Asp Cys Asp Ser Ser Ala Pro Lys Ala Ala Gln Ala Gln Glu Pro 
                245                 250                 255     


Gln Ile Asp Glu Ala Asn Ile Val Asp Asp Phe Gln Glu Tyr Asn Tyr 
            260                 265                 270         


Gly Thr Met Glu Ser Tyr Gln Thr Glu Ala Pro Arg His Val Ser Gly 
        275                 280                 285             


Thr Asn Glu Pro Asn Pro Val Glu Glu Ile Phe Thr Glu Glu Tyr Leu 
    290                 295                 300                 


Thr Gly Glu Asp Tyr Asp Ser Gln Arg Lys Asn Ser Glu Asp Thr Leu 
305                 310                 315                 320 


Tyr Glu Asn Lys Glu Ile Asp Gly Arg Asp Ser Asp Leu Leu Val Asp 
                325                 330                 335     


Gly Asp Leu Gly Glu Tyr Asp Phe Tyr Glu Tyr Lys Glu Tyr Glu Asp 
            340                 345                 350         


Lys Pro Thr Ser Pro Pro Asn Glu Glu Phe Gly Pro Gly Val Pro Ala 
        355                 360                 365             


Glu Thr Asp Ile Thr Glu Thr Ser Ile Asn Gly His Gly Ala Tyr Gly 
    370                 375                 380                 


Glu Lys Gly Gln Lys Gly Glu Pro Ala Val Val Glu Pro Gly Met Leu 
385                 390                 395                 400 


Val Glu Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly Ile Met Gly Pro 
                405                 410                 415     


Pro Gly Leu Gln Gly Pro Thr Gly Pro Pro Gly Asp Pro Gly Asp Arg 
            420                 425                 430         


Gly Pro Pro Gly Arg Pro Gly Leu Pro Gly Ala Asp Gly Leu Pro Gly 
        435                 440                 445             


Pro Pro Gly Thr Met Leu Met Leu Pro Phe Arg Tyr Gly Gly Asp Gly 
    450                 455                 460                 


Ser Lys Gly Pro Thr Ile Ser Ala Gln Glu Ala Gln Ala Gln Ala Ile 
465                 470                 475                 480 


Leu Gln Gln Ala Arg Ile Ala Leu Arg Gly Pro Pro Gly Pro Met Gly 
                485                 490                 495     


Leu Thr Gly Arg Pro Gly Pro Val Gly Gly Pro Gly Ser Ser Gly Ala 
            500                 505                 510         


Lys Gly Glu Ser Gly Asp Pro Gly Pro Gln Gly Pro Arg Gly Val Gln 
        515                 520                 525             


Gly Pro Pro Gly Pro Thr Gly Lys Pro Gly Lys Arg Gly Arg Pro Gly 
    530                 535                 540                 


Ala Asp Gly Gly Arg Gly Met Pro Gly Glu Pro Gly Ala Lys Gly Asp 
545                 550                 555                 560 


Arg Gly Phe Asp Gly Leu Pro Gly Leu Pro Gly Asp Lys Gly His Arg 
                565                 570                 575     


Gly Glu Arg Gly Pro Gln Gly Pro Pro Gly Pro Pro Gly Asp Asp Gly 
            580                 585                 590         


Met Arg Gly Glu Asp Gly Glu Ile Gly Pro Arg Gly Leu Pro Gly Glu 
        595                 600                 605             


Ala Gly Pro Arg Gly Leu Leu Gly Pro Arg Gly Thr Pro Gly Ala Pro 
    610                 615                 620                 


Gly Gln Pro Gly Met Ala Gly Val Asp Gly Pro Pro Gly Pro Lys Gly 
625                 630                 635                 640 


Asn Met Gly Pro Gln Gly Glu Pro Gly Pro Pro Gly Gln Gln Gly Asn 
                645                 650                 655     


Pro Gly Pro Gln Gly Leu Pro Gly Pro Gln Gly Pro Ile Gly Pro Pro 
            660                 665                 670         


Gly Glu Lys Gly Pro Gln Gly Lys Pro Gly Leu Ala Gly Leu Pro Gly 
        675                 680                 685             


Ala Asp Gly Pro Pro Gly His Pro Gly Lys Glu Gly Gln Ser Gly Glu 
    690                 695                 700                 


Lys Gly Ala Leu Gly Pro Pro Gly Pro Gln Gly Pro Ile Gly Tyr Pro 
705                 710                 715                 720 


Gly Pro Arg Gly Val Lys Gly Ala Asp Gly Val Arg Gly Leu Lys Gly 
                725                 730                 735     


Ser Lys Gly Glu Lys Gly Glu Asp Gly Phe Pro Gly Phe Lys Gly Asp 
            740                 745                 750         


Met Gly Leu Lys Gly Asp Arg Gly Glu Val Gly Gln Ile Gly Pro Arg 
        755                 760                 765             


Gly Glu Asp Gly Pro Glu Gly Pro Lys Gly Arg Ala Gly Pro Thr Gly 
    770                 775                 780                 


Asp Pro Gly Pro Ser Gly Gln Ala Gly Glu Lys Gly Lys Leu Gly Val 
785                 790                 795                 800 


Pro Gly Leu Pro Gly Tyr Pro Gly Arg Gln Gly Pro Lys Gly Ser Thr 
                805                 810                 815     


Gly Phe Pro Gly Phe Pro Gly Ala Asn Gly Glu Lys Gly Ala Arg Gly 
            820                 825                 830         


Val Ala Gly Lys Pro Gly Pro Arg Gly Gln Arg Gly Pro Thr Gly Pro 
        835                 840                 845             


Arg Gly Ser Arg Gly Ala Arg Gly Pro Thr Gly Lys Pro Gly Pro Lys 
    850                 855                 860                 


Gly Thr Ser Gly Gly Asp Gly Pro Pro Gly Pro Pro Gly Glu Arg Gly 
865                 870                 875                 880 


Pro Gln Gly Pro Gln Gly Pro Val Gly Phe Pro Gly Pro Lys Gly Pro 
                885                 890                 895     


Pro Gly Pro Pro Gly Lys Asp Gly Leu Pro Gly His Pro Gly Gln Arg 
            900                 905                 910         


Gly Glu Thr Gly Phe Gln Gly Lys Thr Gly Pro Pro Gly Pro Gly Gly 
        915                 920                 925             


Val Val Gly Pro Gln Gly Pro Thr Gly Glu Thr Gly Pro Ile Gly Glu 
    930                 935                 940                 


Arg Gly His Pro Gly Pro Pro Gly Pro Pro Gly Glu Gln Gly Leu Pro 
945                 950                 955                 960 


Gly Ala Ala Gly Lys Glu Gly Ala Lys Gly Asp Pro Gly Pro Gln Gly 
                965                 970                 975     


Ile Ser Gly Lys Asp Gly Pro Ala Gly Leu Arg Gly Phe Pro Gly Glu 
            980                 985                 990         


Arg Gly Leu Pro Gly Ala Gln Gly  Ala Pro Gly Leu Lys  Gly Gly Glu 
        995                 1000                 1005             


Gly Pro  Gln Gly Pro Pro Gly  Pro Val Gly Ser Pro  Gly Glu Arg 
    1010                 1015                 1020             


Gly Ser  Ala Gly Thr Ala Gly  Pro Ile Gly Leu Pro  Gly Arg Pro 
    1025                 1030                 1035             


Gly Pro  Gln Gly Pro Pro Gly  Pro Ala Gly Glu Lys  Gly Ala Pro 
    1040                 1045                 1050             


Gly Glu  Lys Gly Pro Gln Gly  Pro Ala Gly Arg Asp  Gly Val Gln 
    1055                 1060                 1065             


Gly Pro  Val Gly Leu Pro Gly  Pro Ala Gly Pro Ala  Gly Ser Pro 
    1070                 1075                 1080             


Gly Glu  Asp Gly Asp Lys Gly  Glu Ile Gly Glu Pro  Gly Gln Lys 
    1085                 1090                 1095             


Gly Ser  Lys Gly Asp Lys Gly  Glu Asn Gly Pro Pro  Gly Pro Pro 
    1100                 1105                 1110             


Gly Leu  Gln Gly Pro Val Gly  Ala Pro Gly Ile Ala  Gly Gly Asp 
    1115                 1120                 1125             


Gly Glu  Pro Gly Pro Arg Gly  Gln Gln Gly Met Phe  Gly Gln Lys 
    1130                 1135                 1140             


Gly Asp  Glu Gly Ala Arg Gly  Phe Pro Gly Pro Pro  Gly Pro Ile 
    1145                 1150                 1155             


Gly Leu  Gln Gly Leu Pro Gly  Pro Pro Gly Glu Lys  Gly Glu Asn 
    1160                 1165                 1170             


Gly Asp  Val Gly Pro Met Gly  Pro Pro Gly Pro Pro  Gly Pro Arg 
    1175                 1180                 1185             


Gly Pro  Gln Gly Pro Asn Gly  Ala Asp Gly Pro Gln  Gly Pro Pro 
    1190                 1195                 1200             


Gly Ser  Val Gly Ser Val Gly  Gly Val Gly Glu Lys  Gly Glu Pro 
    1205                 1210                 1215             


Gly Glu  Ala Gly Asn Pro Gly  Pro Pro Gly Glu Ala  Gly Val Gly 
    1220                 1225                 1230             


Gly Pro  Lys Gly Glu Arg Gly  Glu Lys Gly Glu Ala  Gly Pro Pro 
    1235                 1240                 1245             


Gly Ala  Ala Gly Pro Pro Gly  Ala Lys Gly Pro Pro  Gly Asp Asp 
    1250                 1255                 1260             


Gly Pro  Lys Gly Asn Pro Gly  Pro Val Gly Phe Pro  Gly Asp Pro 
    1265                 1270                 1275             


Gly Pro  Pro Gly Glu Pro Gly  Pro Ala Gly Gln Asp  Gly Val Gly 
    1280                 1285                 1290             


Gly Asp  Lys Gly Glu Asp Gly  Asp Pro Gly Gln Pro  Gly Pro Pro 
    1295                 1300                 1305             


Gly Pro  Ser Gly Glu Ala Gly  Pro Pro Gly Pro Pro  Gly Lys Arg 
    1310                 1315                 1320             


Gly Pro  Pro Gly Ala Ala Gly  Ala Glu Gly Arg Gln  Gly Glu Lys 
    1325                 1330                 1335             


Gly Ala  Lys Gly Glu Ala Gly  Ala Glu Gly Pro Pro  Gly Lys Thr 
    1340                 1345                 1350             


Gly Pro  Val Gly Pro Gln Gly  Pro Ala Gly Lys Pro  Gly Pro Glu 
    1355                 1360                 1365             


Gly Leu  Arg Gly Ile Pro Gly  Pro Val Gly Glu Gln  Gly Leu Pro 
    1370                 1375                 1380             


Gly Ala  Ala Gly Gln Asp Gly  Pro Pro Gly Pro Met  Gly Pro Pro 
    1385                 1390                 1395             


Gly Leu  Pro Gly Leu Lys Gly  Asp Pro Gly Ser Lys  Gly Glu Lys 
    1400                 1405                 1410             


Gly His  Pro Gly Leu Ile Gly  Leu Ile Gly Pro Pro  Gly Glu Gln 
    1415                 1420                 1425             


Gly Glu  Lys Gly Asp Arg Gly  Leu Pro Gly Thr Gln  Gly Ser Pro 
    1430                 1435                 1440             


Gly Ala  Lys Gly Asp Gly Gly  Ile Pro Gly Pro Ala  Gly Pro Leu 
    1445                 1450                 1455             


Gly Pro  Pro Gly Pro Pro Gly  Leu Pro Gly Pro Gln  Gly Pro Lys 
    1460                 1465                 1470             


Gly Asn  Lys Gly Ser Thr Gly  Pro Ala Gly Gln Lys  Gly Asp Ser 
    1475                 1480                 1485             


Gly Leu  Pro Gly Pro Pro Gly  Ser Pro Gly Pro Pro  Gly Glu Val 
    1490                 1495                 1500             


Ile Gln  Pro Leu Pro Ile Leu  Ser Ser Lys Lys Thr  Arg Arg His 
    1505                 1510                 1515             


Thr Glu  Gly Met Gln Ala Asp  Ala Asp Asp Asn Ile  Leu Asp Tyr 
    1520                 1525                 1530             


Ser Asp  Gly Met Glu Glu Ile  Phe Gly Ser Leu Asn  Ser Leu Lys 
    1535                 1540                 1545             


Gln Asp  Ile Glu His Met Lys  Phe Pro Met Gly Thr  Gln Thr Asn 
    1550                 1555                 1560             


Pro Ala  Arg Thr Cys Lys Asp  Leu Gln Leu Ser His  Pro Asp Phe 
    1565                 1570                 1575             


Pro Asp  Gly Glu Tyr Trp Ile  Asp Pro Asn Gln Gly  Cys Ser Gly 
    1580                 1585                 1590             


Asp Ser  Phe Lys Val Tyr Cys  Asn Phe Thr Ser Gly  Gly Glu Thr 
    1595                 1600                 1605             


Cys Ile  Tyr Pro Asp Lys Lys  Ser Glu Gly Val Arg  Ile Ser Ser 
    1610                 1615                 1620             


Trp Pro  Lys Glu Lys Pro Gly  Ser Trp Phe Ser Glu  Phe Lys Arg 
    1625                 1630                 1635             


Gly Lys  Leu Leu Ser Tyr Leu  Asp Val Glu Gly Asn  Ser Ile Asn 
    1640                 1645                 1650             


Met Val  Gln Met Thr Phe Leu  Lys Leu Leu Thr Ala  Ser Ala Arg 
    1655                 1660                 1665             


Gln Asn  Phe Thr Tyr His Cys  His Gln Ser Ala Ala  Trp Tyr Asp 
    1670                 1675                 1680             


Val Ser  Ser Gly Ser Tyr Asp  Lys Ala Leu Arg Phe  Leu Gly Ser 
    1685                 1690                 1695             


Asn Asp  Glu Glu Met Ser Tyr  Asp Asn Asn Pro Phe  Ile Lys Thr 
    1700                 1705                 1710             


Leu Tyr  Asp Gly Cys Ala Ser  Arg Lys Gly Tyr Glu  Lys Thr Val 
    1715                 1720                 1725             


Ile Glu  Ile Asn Thr Pro Lys  Ile Asp Gln Val Pro  Ile Val Asp 
    1730                 1735                 1740             


Val Met  Ile Asn Asp Phe Gly  Asp Gln Asn Gln Lys  Phe Gly Phe 
    1745                 1750                 1755             


Glu Val  Gly Pro Val Cys Phe  Leu Gly 
    1760                 1765         


<210>  3208
<211>  1806
<212>  PRT
<213>  Homo Sapiens

<400>  3208

Met Glu Pro Trp Ser Ser Arg Trp Lys Thr Lys Arg Trp Leu Trp Asp 
1               5                   10                  15      


Phe Thr Val Thr Thr Leu Ala Leu Thr Phe Leu Phe Gln Ala Arg Glu 
            20                  25                  30          


Val Arg Gly Ala Ala Pro Val Asp Val Leu Lys Ala Leu Asp Phe His 
        35                  40                  45              


Asn Ser Pro Glu Gly Ile Ser Lys Thr Thr Gly Phe Cys Thr Asn Arg 
    50                  55                  60                  


Lys Asn Ser Lys Gly Ser Asp Thr Ala Tyr Arg Val Ser Lys Gln Ala 
65                  70                  75                  80  


Gln Leu Ser Ala Pro Thr Lys Gln Leu Phe Pro Gly Gly Thr Phe Pro 
                85                  90                  95      


Glu Asp Phe Ser Ile Leu Phe Thr Val Lys Pro Lys Lys Gly Ile Gln 
            100                 105                 110         


Ser Phe Leu Leu Ser Ile Tyr Asn Glu His Gly Ile Gln Gln Ile Gly 
        115                 120                 125             


Val Glu Val Gly Arg Ser Pro Val Phe Leu Phe Glu Asp His Thr Gly 
    130                 135                 140                 


Lys Pro Ala Pro Glu Asp Tyr Pro Leu Phe Arg Thr Val Asn Ile Ala 
145                 150                 155                 160 


Asp Gly Lys Trp His Arg Val Ala Ile Ser Val Glu Lys Lys Thr Val 
                165                 170                 175     


Thr Met Ile Val Asp Cys Lys Lys Lys Thr Thr Lys Pro Leu Asp Arg 
            180                 185                 190         


Ser Glu Arg Ala Ile Val Asp Thr Asn Gly Ile Thr Val Phe Gly Thr 
        195                 200                 205             


Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Ile Gln Gln Phe Leu 
    210                 215                 220                 


Ile Thr Gly Asp Pro Lys Ala Ala Tyr Asp Tyr Cys Glu His Tyr Ser 
225                 230                 235                 240 


Pro Asp Cys Asp Ser Ser Ala Pro Lys Ala Ala Gln Ala Gln Glu Pro 
                245                 250                 255     


Gln Ile Asp Glu Tyr Ala Pro Glu Asp Ile Ile Glu Tyr Asp Tyr Glu 
            260                 265                 270         


Tyr Gly Glu Ala Glu Tyr Lys Glu Ala Glu Ser Val Thr Glu Gly Pro 
        275                 280                 285             


Thr Val Thr Glu Glu Thr Ile Ala Gln Thr Glu Ala Asn Ile Val Asp 
    290                 295                 300                 


Asp Phe Gln Glu Tyr Asn Tyr Gly Thr Met Glu Ser Tyr Gln Thr Glu 
305                 310                 315                 320 


Ala Pro Arg His Val Ser Gly Thr Asn Glu Pro Asn Pro Val Glu Glu 
                325                 330                 335     


Ile Phe Thr Glu Glu Tyr Leu Thr Gly Glu Asp Tyr Asp Ser Gln Arg 
            340                 345                 350         


Lys Asn Ser Glu Asp Thr Leu Tyr Glu Asn Lys Glu Ile Asp Gly Arg 
        355                 360                 365             


Asp Ser Asp Leu Leu Val Asp Gly Asp Leu Gly Glu Tyr Asp Phe Tyr 
    370                 375                 380                 


Glu Tyr Lys Glu Tyr Glu Asp Lys Pro Thr Ser Pro Pro Asn Glu Glu 
385                 390                 395                 400 


Phe Gly Pro Gly Val Pro Ala Glu Thr Asp Ile Thr Glu Thr Ser Ile 
                405                 410                 415     


Asn Gly His Gly Ala Tyr Gly Glu Lys Gly Gln Lys Gly Glu Pro Ala 
            420                 425                 430         


Val Val Glu Pro Gly Met Leu Val Glu Gly Pro Pro Gly Pro Ala Gly 
        435                 440                 445             


Pro Ala Gly Ile Met Gly Pro Pro Gly Leu Gln Gly Pro Thr Gly Pro 
    450                 455                 460                 


Pro Gly Asp Pro Gly Asp Arg Gly Pro Pro Gly Arg Pro Gly Leu Pro 
465                 470                 475                 480 


Gly Ala Asp Gly Leu Pro Gly Pro Pro Gly Thr Met Leu Met Leu Pro 
                485                 490                 495     


Phe Arg Tyr Gly Gly Asp Gly Ser Lys Gly Pro Thr Ile Ser Ala Gln 
            500                 505                 510         


Glu Ala Gln Ala Gln Ala Ile Leu Gln Gln Ala Arg Ile Ala Leu Arg 
        515                 520                 525             


Gly Pro Pro Gly Pro Met Gly Leu Thr Gly Arg Pro Gly Pro Val Gly 
    530                 535                 540                 


Gly Pro Gly Ser Ser Gly Ala Lys Gly Glu Ser Gly Asp Pro Gly Pro 
545                 550                 555                 560 


Gln Gly Pro Arg Gly Val Gln Gly Pro Pro Gly Pro Thr Gly Lys Pro 
                565                 570                 575     


Gly Lys Arg Gly Arg Pro Gly Ala Asp Gly Gly Arg Gly Met Pro Gly 
            580                 585                 590         


Glu Pro Gly Ala Lys Gly Asp Arg Gly Phe Asp Gly Leu Pro Gly Leu 
        595                 600                 605             


Pro Gly Asp Lys Gly His Arg Gly Glu Arg Gly Pro Gln Gly Pro Pro 
    610                 615                 620                 


Gly Pro Pro Gly Asp Asp Gly Met Arg Gly Glu Asp Gly Glu Ile Gly 
625                 630                 635                 640 


Pro Arg Gly Leu Pro Gly Glu Ala Gly Pro Arg Gly Leu Leu Gly Pro 
                645                 650                 655     


Arg Gly Thr Pro Gly Ala Pro Gly Gln Pro Gly Met Ala Gly Val Asp 
            660                 665                 670         


Gly Pro Pro Gly Pro Lys Gly Asn Met Gly Pro Gln Gly Glu Pro Gly 
        675                 680                 685             


Pro Pro Gly Gln Gln Gly Asn Pro Gly Pro Gln Gly Leu Pro Gly Pro 
    690                 695                 700                 


Gln Gly Pro Ile Gly Pro Pro Gly Glu Lys Gly Pro Gln Gly Lys Pro 
705                 710                 715                 720 


Gly Leu Ala Gly Leu Pro Gly Ala Asp Gly Pro Pro Gly His Pro Gly 
                725                 730                 735     


Lys Glu Gly Gln Ser Gly Glu Lys Gly Ala Leu Gly Pro Pro Gly Pro 
            740                 745                 750         


Gln Gly Pro Ile Gly Tyr Pro Gly Pro Arg Gly Val Lys Gly Ala Asp 
        755                 760                 765             


Gly Val Arg Gly Leu Lys Gly Ser Lys Gly Glu Lys Gly Glu Asp Gly 
    770                 775                 780                 


Phe Pro Gly Phe Lys Gly Asp Met Gly Leu Lys Gly Asp Arg Gly Glu 
785                 790                 795                 800 


Val Gly Gln Ile Gly Pro Arg Gly Glu Asp Gly Pro Glu Gly Pro Lys 
                805                 810                 815     


Gly Arg Ala Gly Pro Thr Gly Asp Pro Gly Pro Ser Gly Gln Ala Gly 
            820                 825                 830         


Glu Lys Gly Lys Leu Gly Val Pro Gly Leu Pro Gly Tyr Pro Gly Arg 
        835                 840                 845             


Gln Gly Pro Lys Gly Ser Thr Gly Phe Pro Gly Phe Pro Gly Ala Asn 
    850                 855                 860                 


Gly Glu Lys Gly Ala Arg Gly Val Ala Gly Lys Pro Gly Pro Arg Gly 
865                 870                 875                 880 


Gln Arg Gly Pro Thr Gly Pro Arg Gly Ser Arg Gly Ala Arg Gly Pro 
                885                 890                 895     


Thr Gly Lys Pro Gly Pro Lys Gly Thr Ser Gly Gly Asp Gly Pro Pro 
            900                 905                 910         


Gly Pro Pro Gly Glu Arg Gly Pro Gln Gly Pro Gln Gly Pro Val Gly 
        915                 920                 925             


Phe Pro Gly Pro Lys Gly Pro Pro Gly Pro Pro Gly Lys Asp Gly Leu 
    930                 935                 940                 


Pro Gly His Pro Gly Gln Arg Gly Glu Thr Gly Phe Gln Gly Lys Thr 
945                 950                 955                 960 


Gly Pro Pro Gly Pro Gly Gly Val Val Gly Pro Gln Gly Pro Thr Gly 
                965                 970                 975     


Glu Thr Gly Pro Ile Gly Glu Arg Gly His Pro Gly Pro Pro Gly Pro 
            980                 985                 990         


Pro Gly Glu Gln Gly Leu Pro Gly  Ala Ala Gly Lys Glu  Gly Ala Lys 
        995                 1000                 1005             


Gly Asp  Pro Gly Pro Gln Gly  Ile Ser Gly Lys Asp  Gly Pro Ala 
    1010                 1015                 1020             


Gly Leu  Arg Gly Phe Pro Gly  Glu Arg Gly Leu Pro  Gly Ala Gln 
    1025                 1030                 1035             


Gly Ala  Pro Gly Leu Lys Gly  Gly Glu Gly Pro Gln  Gly Pro Pro 
    1040                 1045                 1050             


Gly Pro  Val Gly Ser Pro Gly  Glu Arg Gly Ser Ala  Gly Thr Ala 
    1055                 1060                 1065             


Gly Pro  Ile Gly Leu Pro Gly  Arg Pro Gly Pro Gln  Gly Pro Pro 
    1070                 1075                 1080             


Gly Pro  Ala Gly Glu Lys Gly  Ala Pro Gly Glu Lys  Gly Pro Gln 
    1085                 1090                 1095             


Gly Pro  Ala Gly Arg Asp Gly  Val Gln Gly Pro Val  Gly Leu Pro 
    1100                 1105                 1110             


Gly Pro  Ala Gly Pro Ala Gly  Ser Pro Gly Glu Asp  Gly Asp Lys 
    1115                 1120                 1125             


Gly Glu  Ile Gly Glu Pro Gly  Gln Lys Gly Ser Lys  Gly Asp Lys 
    1130                 1135                 1140             


Gly Glu  Asn Gly Pro Pro Gly  Pro Pro Gly Leu Gln  Gly Pro Val 
    1145                 1150                 1155             


Gly Ala  Pro Gly Ile Ala Gly  Gly Asp Gly Glu Pro  Gly Pro Arg 
    1160                 1165                 1170             


Gly Gln  Gln Gly Met Phe Gly  Gln Lys Gly Asp Glu  Gly Ala Arg 
    1175                 1180                 1185             


Gly Phe  Pro Gly Pro Pro Gly  Pro Ile Gly Leu Gln  Gly Leu Pro 
    1190                 1195                 1200             


Gly Pro  Pro Gly Glu Lys Gly  Glu Asn Gly Asp Val  Gly Pro Met 
    1205                 1210                 1215             


Gly Pro  Pro Gly Pro Pro Gly  Pro Arg Gly Pro Gln  Gly Pro Asn 
    1220                 1225                 1230             


Gly Ala  Asp Gly Pro Gln Gly  Pro Pro Gly Ser Val  Gly Ser Val 
    1235                 1240                 1245             


Gly Gly  Val Gly Glu Lys Gly  Glu Pro Gly Glu Ala  Gly Asn Pro 
    1250                 1255                 1260             


Gly Pro  Pro Gly Glu Ala Gly  Val Gly Gly Pro Lys  Gly Glu Arg 
    1265                 1270                 1275             


Gly Glu  Lys Gly Glu Ala Gly  Pro Pro Gly Ala Ala  Gly Pro Pro 
    1280                 1285                 1290             


Gly Ala  Lys Gly Pro Pro Gly  Asp Asp Gly Pro Lys  Gly Asn Pro 
    1295                 1300                 1305             


Gly Pro  Val Gly Phe Pro Gly  Asp Pro Gly Pro Pro  Gly Glu Pro 
    1310                 1315                 1320             


Gly Pro  Ala Gly Gln Asp Gly  Val Gly Gly Asp Lys  Gly Glu Asp 
    1325                 1330                 1335             


Gly Asp  Pro Gly Gln Pro Gly  Pro Pro Gly Pro Ser  Gly Glu Ala 
    1340                 1345                 1350             


Gly Pro  Pro Gly Pro Pro Gly  Lys Arg Gly Pro Pro  Gly Ala Ala 
    1355                 1360                 1365             


Gly Ala  Glu Gly Arg Gln Gly  Glu Lys Gly Ala Lys  Gly Glu Ala 
    1370                 1375                 1380             


Gly Ala  Glu Gly Pro Pro Gly  Lys Thr Gly Pro Val  Gly Pro Gln 
    1385                 1390                 1395             


Gly Pro  Ala Gly Lys Pro Gly  Pro Glu Gly Leu Arg  Gly Ile Pro 
    1400                 1405                 1410             


Gly Pro  Val Gly Glu Gln Gly  Leu Pro Gly Ala Ala  Gly Gln Asp 
    1415                 1420                 1425             


Gly Pro  Pro Gly Pro Met Gly  Pro Pro Gly Leu Pro  Gly Leu Lys 
    1430                 1435                 1440             


Gly Asp  Pro Gly Ser Lys Gly  Glu Lys Gly His Pro  Gly Leu Ile 
    1445                 1450                 1455             


Gly Leu  Ile Gly Pro Pro Gly  Glu Gln Gly Glu Lys  Gly Asp Arg 
    1460                 1465                 1470             


Gly Leu  Pro Gly Thr Gln Gly  Ser Pro Gly Ala Lys  Gly Asp Gly 
    1475                 1480                 1485             


Gly Ile  Pro Gly Pro Ala Gly  Pro Leu Gly Pro Pro  Gly Pro Pro 
    1490                 1495                 1500             


Gly Leu  Pro Gly Pro Gln Gly  Pro Lys Gly Asn Lys  Gly Ser Thr 
    1505                 1510                 1515             


Gly Pro  Ala Gly Gln Lys Gly  Asp Ser Gly Leu Pro  Gly Pro Pro 
    1520                 1525                 1530             


Gly Ser  Pro Gly Pro Pro Gly  Glu Val Ile Gln Pro  Leu Pro Ile 
    1535                 1540                 1545             


Leu Ser  Ser Lys Lys Thr Arg  Arg His Thr Glu Gly  Met Gln Ala 
    1550                 1555                 1560             


Asp Ala  Asp Asp Asn Ile Leu  Asp Tyr Ser Asp Gly  Met Glu Glu 
    1565                 1570                 1575             


Ile Phe  Gly Ser Leu Asn Ser  Leu Lys Gln Asp Ile  Glu His Met 
    1580                 1585                 1590             


Lys Phe  Pro Met Gly Thr Gln  Thr Asn Pro Ala Arg  Thr Cys Lys 
    1595                 1600                 1605             


Asp Leu  Gln Leu Ser His Pro  Asp Phe Pro Asp Gly  Glu Tyr Trp 
    1610                 1615                 1620             


Ile Asp  Pro Asn Gln Gly Cys  Ser Gly Asp Ser Phe  Lys Val Tyr 
    1625                 1630                 1635             


Cys Asn  Phe Thr Ser Gly Gly  Glu Thr Cys Ile Tyr  Pro Asp Lys 
    1640                 1645                 1650             


Lys Ser  Glu Gly Val Arg Ile  Ser Ser Trp Pro Lys  Glu Lys Pro 
    1655                 1660                 1665             


Gly Ser  Trp Phe Ser Glu Phe  Lys Arg Gly Lys Leu  Leu Ser Tyr 
    1670                 1675                 1680             


Leu Asp  Val Glu Gly Asn Ser  Ile Asn Met Val Gln  Met Thr Phe 
    1685                 1690                 1695             


Leu Lys  Leu Leu Thr Ala Ser  Ala Arg Gln Asn Phe  Thr Tyr His 
    1700                 1705                 1710             


Cys His  Gln Ser Ala Ala Trp  Tyr Asp Val Ser Ser  Gly Ser Tyr 
    1715                 1720                 1725             


Asp Lys  Ala Leu Arg Phe Leu  Gly Ser Asn Asp Glu  Glu Met Ser 
    1730                 1735                 1740             


Tyr Asp  Asn Asn Pro Phe Ile  Lys Thr Leu Tyr Asp  Gly Cys Ala 
    1745                 1750                 1755             


Ser Arg  Lys Gly Tyr Glu Lys  Thr Val Ile Glu Ile  Asn Thr Pro 
    1760                 1765                 1770             


Lys Ile  Asp Gln Val Pro Ile  Val Asp Val Met Ile  Asn Asp Phe 
    1775                 1780                 1785             


Gly Asp  Gln Asn Gln Lys Phe  Gly Phe Glu Val Gly  Pro Val Cys 
    1790                 1795                 1800             


Phe Leu  Gly 
    1805     


<210>  3209
<211>  1818
<212>  PRT
<213>  Homo Sapiens

<400>  3209

Met Glu Pro Trp Ser Ser Arg Trp Lys Thr Lys Arg Trp Leu Trp Asp 
1               5                   10                  15      


Phe Thr Val Thr Thr Leu Ala Leu Thr Phe Leu Phe Gln Ala Arg Glu 
            20                  25                  30          


Val Arg Gly Ala Ala Pro Val Asp Val Leu Lys Ala Leu Asp Phe His 
        35                  40                  45              


Asn Ser Pro Glu Gly Ile Ser Lys Thr Thr Gly Phe Cys Thr Asn Arg 
    50                  55                  60                  


Lys Asn Ser Lys Gly Ser Asp Thr Ala Tyr Arg Val Ser Lys Gln Ala 
65                  70                  75                  80  


Gln Leu Ser Ala Pro Thr Lys Gln Leu Phe Pro Gly Gly Thr Phe Pro 
                85                  90                  95      


Glu Asp Phe Ser Ile Leu Phe Thr Val Lys Pro Lys Lys Gly Ile Gln 
            100                 105                 110         


Ser Phe Leu Leu Ser Ile Tyr Asn Glu His Gly Ile Gln Gln Ile Gly 
        115                 120                 125             


Val Glu Val Gly Arg Ser Pro Val Phe Leu Phe Glu Asp His Thr Gly 
    130                 135                 140                 


Lys Pro Ala Pro Glu Asp Tyr Pro Leu Phe Arg Thr Val Asn Ile Ala 
145                 150                 155                 160 


Asp Gly Lys Trp His Arg Val Ala Ile Ser Val Glu Lys Lys Thr Val 
                165                 170                 175     


Thr Met Ile Val Asp Cys Lys Lys Lys Thr Thr Lys Pro Leu Asp Arg 
            180                 185                 190         


Ser Glu Arg Ala Ile Val Asp Thr Asn Gly Ile Thr Val Phe Gly Thr 
        195                 200                 205             


Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Ile Gln Gln Phe Leu 
    210                 215                 220                 


Ile Thr Gly Asp Pro Lys Ala Ala Tyr Asp Tyr Cys Glu His Tyr Ser 
225                 230                 235                 240 


Pro Asp Cys Asp Ser Ser Ala Pro Lys Ala Ala Gln Ala Gln Glu Pro 
                245                 250                 255     


Gln Ile Asp Glu Lys Lys Lys Ser Asn Phe Lys Lys Lys Met Arg Thr 
            260                 265                 270         


Val Ala Thr Lys Ser Lys Glu Lys Ser Lys Lys Phe Thr Pro Pro Lys 
        275                 280                 285             


Ser Glu Lys Phe Ser Ser Lys Lys Lys Lys Ser Tyr Gln Ala Ser Ala 
    290                 295                 300                 


Lys Ala Lys Leu Gly Val Lys Ala Asn Ile Val Asp Asp Phe Gln Glu 
305                 310                 315                 320 


Tyr Asn Tyr Gly Thr Met Glu Ser Tyr Gln Thr Glu Ala Pro Arg His 
                325                 330                 335     


Val Ser Gly Thr Asn Glu Pro Asn Pro Val Glu Glu Ile Phe Thr Glu 
            340                 345                 350         


Glu Tyr Leu Thr Gly Glu Asp Tyr Asp Ser Gln Arg Lys Asn Ser Glu 
        355                 360                 365             


Asp Thr Leu Tyr Glu Asn Lys Glu Ile Asp Gly Arg Asp Ser Asp Leu 
    370                 375                 380                 


Leu Val Asp Gly Asp Leu Gly Glu Tyr Asp Phe Tyr Glu Tyr Lys Glu 
385                 390                 395                 400 


Tyr Glu Asp Lys Pro Thr Ser Pro Pro Asn Glu Glu Phe Gly Pro Gly 
                405                 410                 415     


Val Pro Ala Glu Thr Asp Ile Thr Glu Thr Ser Ile Asn Gly His Gly 
            420                 425                 430         


Ala Tyr Gly Glu Lys Gly Gln Lys Gly Glu Pro Ala Val Val Glu Pro 
        435                 440                 445             


Gly Met Leu Val Glu Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly Ile 
    450                 455                 460                 


Met Gly Pro Pro Gly Leu Gln Gly Pro Thr Gly Pro Pro Gly Asp Pro 
465                 470                 475                 480 


Gly Asp Arg Gly Pro Pro Gly Arg Pro Gly Leu Pro Gly Ala Asp Gly 
                485                 490                 495     


Leu Pro Gly Pro Pro Gly Thr Met Leu Met Leu Pro Phe Arg Tyr Gly 
            500                 505                 510         


Gly Asp Gly Ser Lys Gly Pro Thr Ile Ser Ala Gln Glu Ala Gln Ala 
        515                 520                 525             


Gln Ala Ile Leu Gln Gln Ala Arg Ile Ala Leu Arg Gly Pro Pro Gly 
    530                 535                 540                 


Pro Met Gly Leu Thr Gly Arg Pro Gly Pro Val Gly Gly Pro Gly Ser 
545                 550                 555                 560 


Ser Gly Ala Lys Gly Glu Ser Gly Asp Pro Gly Pro Gln Gly Pro Arg 
                565                 570                 575     


Gly Val Gln Gly Pro Pro Gly Pro Thr Gly Lys Pro Gly Lys Arg Gly 
            580                 585                 590         


Arg Pro Gly Ala Asp Gly Gly Arg Gly Met Pro Gly Glu Pro Gly Ala 
        595                 600                 605             


Lys Gly Asp Arg Gly Phe Asp Gly Leu Pro Gly Leu Pro Gly Asp Lys 
    610                 615                 620                 


Gly His Arg Gly Glu Arg Gly Pro Gln Gly Pro Pro Gly Pro Pro Gly 
625                 630                 635                 640 


Asp Asp Gly Met Arg Gly Glu Asp Gly Glu Ile Gly Pro Arg Gly Leu 
                645                 650                 655     


Pro Gly Glu Ala Gly Pro Arg Gly Leu Leu Gly Pro Arg Gly Thr Pro 
            660                 665                 670         


Gly Ala Pro Gly Gln Pro Gly Met Ala Gly Val Asp Gly Pro Pro Gly 
        675                 680                 685             


Pro Lys Gly Asn Met Gly Pro Gln Gly Glu Pro Gly Pro Pro Gly Gln 
    690                 695                 700                 


Gln Gly Asn Pro Gly Pro Gln Gly Leu Pro Gly Pro Gln Gly Pro Ile 
705                 710                 715                 720 


Gly Pro Pro Gly Glu Lys Gly Pro Gln Gly Lys Pro Gly Leu Ala Gly 
                725                 730                 735     


Leu Pro Gly Ala Asp Gly Pro Pro Gly His Pro Gly Lys Glu Gly Gln 
            740                 745                 750         


Ser Gly Glu Lys Gly Ala Leu Gly Pro Pro Gly Pro Gln Gly Pro Ile 
        755                 760                 765             


Gly Tyr Pro Gly Pro Arg Gly Val Lys Gly Ala Asp Gly Val Arg Gly 
    770                 775                 780                 


Leu Lys Gly Ser Lys Gly Glu Lys Gly Glu Asp Gly Phe Pro Gly Phe 
785                 790                 795                 800 


Lys Gly Asp Met Gly Leu Lys Gly Asp Arg Gly Glu Val Gly Gln Ile 
                805                 810                 815     


Gly Pro Arg Gly Glu Asp Gly Pro Glu Gly Pro Lys Gly Arg Ala Gly 
            820                 825                 830         


Pro Thr Gly Asp Pro Gly Pro Ser Gly Gln Ala Gly Glu Lys Gly Lys 
        835                 840                 845             


Leu Gly Val Pro Gly Leu Pro Gly Tyr Pro Gly Arg Gln Gly Pro Lys 
    850                 855                 860                 


Gly Ser Thr Gly Phe Pro Gly Phe Pro Gly Ala Asn Gly Glu Lys Gly 
865                 870                 875                 880 


Ala Arg Gly Val Ala Gly Lys Pro Gly Pro Arg Gly Gln Arg Gly Pro 
                885                 890                 895     


Thr Gly Pro Arg Gly Ser Arg Gly Ala Arg Gly Pro Thr Gly Lys Pro 
            900                 905                 910         


Gly Pro Lys Gly Thr Ser Gly Gly Asp Gly Pro Pro Gly Pro Pro Gly 
        915                 920                 925             


Glu Arg Gly Pro Gln Gly Pro Gln Gly Pro Val Gly Phe Pro Gly Pro 
    930                 935                 940                 


Lys Gly Pro Pro Gly Pro Pro Gly Lys Asp Gly Leu Pro Gly His Pro 
945                 950                 955                 960 


Gly Gln Arg Gly Glu Thr Gly Phe Gln Gly Lys Thr Gly Pro Pro Gly 
                965                 970                 975     


Pro Gly Gly Val Val Gly Pro Gln Gly Pro Thr Gly Glu Thr Gly Pro 
            980                 985                 990         


Ile Gly Glu Arg Gly His Pro Gly  Pro Pro Gly Pro Pro  Gly Glu Gln 
        995                 1000                 1005             


Gly Leu  Pro Gly Ala Ala Gly  Lys Glu Gly Ala Lys  Gly Asp Pro 
    1010                 1015                 1020             


Gly Pro  Gln Gly Ile Ser Gly  Lys Asp Gly Pro Ala  Gly Leu Arg 
    1025                 1030                 1035             


Gly Phe  Pro Gly Glu Arg Gly  Leu Pro Gly Ala Gln  Gly Ala Pro 
    1040                 1045                 1050             


Gly Leu  Lys Gly Gly Glu Gly  Pro Gln Gly Pro Pro  Gly Pro Val 
    1055                 1060                 1065             


Gly Ser  Pro Gly Glu Arg Gly  Ser Ala Gly Thr Ala  Gly Pro Ile 
    1070                 1075                 1080             


Gly Leu  Pro Gly Arg Pro Gly  Pro Gln Gly Pro Pro  Gly Pro Ala 
    1085                 1090                 1095             


Gly Glu  Lys Gly Ala Pro Gly  Glu Lys Gly Pro Gln  Gly Pro Ala 
    1100                 1105                 1110             


Gly Arg  Asp Gly Val Gln Gly  Pro Val Gly Leu Pro  Gly Pro Ala 
    1115                 1120                 1125             


Gly Pro  Ala Gly Ser Pro Gly  Glu Asp Gly Asp Lys  Gly Glu Ile 
    1130                 1135                 1140             


Gly Glu  Pro Gly Gln Lys Gly  Ser Lys Gly Asp Lys  Gly Glu Asn 
    1145                 1150                 1155             


Gly Pro  Pro Gly Pro Pro Gly  Leu Gln Gly Pro Val  Gly Ala Pro 
    1160                 1165                 1170             


Gly Ile  Ala Gly Gly Asp Gly  Glu Pro Gly Pro Arg  Gly Gln Gln 
    1175                 1180                 1185             


Gly Met  Phe Gly Gln Lys Gly  Asp Glu Gly Ala Arg  Gly Phe Pro 
    1190                 1195                 1200             


Gly Pro  Pro Gly Pro Ile Gly  Leu Gln Gly Leu Pro  Gly Pro Pro 
    1205                 1210                 1215             


Gly Glu  Lys Gly Glu Asn Gly  Asp Val Gly Pro Met  Gly Pro Pro 
    1220                 1225                 1230             


Gly Pro  Pro Gly Pro Arg Gly  Pro Gln Gly Pro Asn  Gly Ala Asp 
    1235                 1240                 1245             


Gly Pro  Gln Gly Pro Pro Gly  Ser Val Gly Ser Val  Gly Gly Val 
    1250                 1255                 1260             


Gly Glu  Lys Gly Glu Pro Gly  Glu Ala Gly Asn Pro  Gly Pro Pro 
    1265                 1270                 1275             


Gly Glu  Ala Gly Val Gly Gly  Pro Lys Gly Glu Arg  Gly Glu Lys 
    1280                 1285                 1290             


Gly Glu  Ala Gly Pro Pro Gly  Ala Ala Gly Pro Pro  Gly Ala Lys 
    1295                 1300                 1305             


Gly Pro  Pro Gly Asp Asp Gly  Pro Lys Gly Asn Pro  Gly Pro Val 
    1310                 1315                 1320             


Gly Phe  Pro Gly Asp Pro Gly  Pro Pro Gly Glu Pro  Gly Pro Ala 
    1325                 1330                 1335             


Gly Gln  Asp Gly Val Gly Gly  Asp Lys Gly Glu Asp  Gly Asp Pro 
    1340                 1345                 1350             


Gly Gln  Pro Gly Pro Pro Gly  Pro Ser Gly Glu Ala  Gly Pro Pro 
    1355                 1360                 1365             


Gly Pro  Pro Gly Lys Arg Gly  Pro Pro Gly Ala Ala  Gly Ala Glu 
    1370                 1375                 1380             


Gly Arg  Gln Gly Glu Lys Gly  Ala Lys Gly Glu Ala  Gly Ala Glu 
    1385                 1390                 1395             


Gly Pro  Pro Gly Lys Thr Gly  Pro Val Gly Pro Gln  Gly Pro Ala 
    1400                 1405                 1410             


Gly Lys  Pro Gly Pro Glu Gly  Leu Arg Gly Ile Pro  Gly Pro Val 
    1415                 1420                 1425             


Gly Glu  Gln Gly Leu Pro Gly  Ala Ala Gly Gln Asp  Gly Pro Pro 
    1430                 1435                 1440             


Gly Pro  Met Gly Pro Pro Gly  Leu Pro Gly Leu Lys  Gly Asp Pro 
    1445                 1450                 1455             


Gly Ser  Lys Gly Glu Lys Gly  His Pro Gly Leu Ile  Gly Leu Ile 
    1460                 1465                 1470             


Gly Pro  Pro Gly Glu Gln Gly  Glu Lys Gly Asp Arg  Gly Leu Pro 
    1475                 1480                 1485             


Gly Thr  Gln Gly Ser Pro Gly  Ala Lys Gly Asp Gly  Gly Ile Pro 
    1490                 1495                 1500             


Gly Pro  Ala Gly Pro Leu Gly  Pro Pro Gly Pro Pro  Gly Leu Pro 
    1505                 1510                 1515             


Gly Pro  Gln Gly Pro Lys Gly  Asn Lys Gly Ser Thr  Gly Pro Ala 
    1520                 1525                 1530             


Gly Gln  Lys Gly Asp Ser Gly  Leu Pro Gly Pro Pro  Gly Ser Pro 
    1535                 1540                 1545             


Gly Pro  Pro Gly Glu Val Ile  Gln Pro Leu Pro Ile  Leu Ser Ser 
    1550                 1555                 1560             


Lys Lys  Thr Arg Arg His Thr  Glu Gly Met Gln Ala  Asp Ala Asp 
    1565                 1570                 1575             


Asp Asn  Ile Leu Asp Tyr Ser  Asp Gly Met Glu Glu  Ile Phe Gly 
    1580                 1585                 1590             


Ser Leu  Asn Ser Leu Lys Gln  Asp Ile Glu His Met  Lys Phe Pro 
    1595                 1600                 1605             


Met Gly  Thr Gln Thr Asn Pro  Ala Arg Thr Cys Lys  Asp Leu Gln 
    1610                 1615                 1620             


Leu Ser  His Pro Asp Phe Pro  Asp Gly Glu Tyr Trp  Ile Asp Pro 
    1625                 1630                 1635             


Asn Gln  Gly Cys Ser Gly Asp  Ser Phe Lys Val Tyr  Cys Asn Phe 
    1640                 1645                 1650             


Thr Ser  Gly Gly Glu Thr Cys  Ile Tyr Pro Asp Lys  Lys Ser Glu 
    1655                 1660                 1665             


Gly Val  Arg Ile Ser Ser Trp  Pro Lys Glu Lys Pro  Gly Ser Trp 
    1670                 1675                 1680             


Phe Ser  Glu Phe Lys Arg Gly  Lys Leu Leu Ser Tyr  Leu Asp Val 
    1685                 1690                 1695             


Glu Gly  Asn Ser Ile Asn Met  Val Gln Met Thr Phe  Leu Lys Leu 
    1700                 1705                 1710             


Leu Thr  Ala Ser Ala Arg Gln  Asn Phe Thr Tyr His  Cys His Gln 
    1715                 1720                 1725             


Ser Ala  Ala Trp Tyr Asp Val  Ser Ser Gly Ser Tyr  Asp Lys Ala 
    1730                 1735                 1740             


Leu Arg  Phe Leu Gly Ser Asn  Asp Glu Glu Met Ser  Tyr Asp Asn 
    1745                 1750                 1755             


Asn Pro  Phe Ile Lys Thr Leu  Tyr Asp Gly Cys Ala  Ser Arg Lys 
    1760                 1765                 1770             


Gly Tyr  Glu Lys Thr Val Ile  Glu Ile Asn Thr Pro  Lys Ile Asp 
    1775                 1780                 1785             


Gln Val  Pro Ile Val Asp Val  Met Ile Asn Asp Phe  Gly Asp Gln 
    1790                 1795                 1800             


Asn Gln  Lys Phe Gly Phe Glu  Val Gly Pro Val Cys  Phe Leu Gly 
    1805                 1810                 1815             


<210>  3210
<211>  780
<212>  PRT
<213>  Homo Sapiens

<400>  3210

Met Glu Pro Trp Ser Ser Arg Trp Lys Thr Lys Arg Trp Leu Trp Asp 
1               5                   10                  15      


Phe Thr Val Thr Thr Leu Ala Leu Thr Phe Leu Phe Gln Ala Arg Glu 
            20                  25                  30          


Val Arg Gly Ala Ala Pro Val Asp Val Leu Lys Ala Leu Asp Phe His 
        35                  40                  45              


Asn Ser Pro Glu Gly Ile Ser Lys Thr Thr Gly Phe Cys Thr Asn Arg 
    50                  55                  60                  


Lys Asn Ser Lys Gly Ser Asp Thr Ala Tyr Arg Val Ser Lys Gln Ala 
65                  70                  75                  80  


Gln Leu Ser Ala Pro Thr Lys Gln Leu Phe Pro Gly Gly Thr Phe Pro 
                85                  90                  95      


Glu Asp Phe Ser Ile Leu Phe Thr Val Lys Pro Lys Lys Gly Ile Gln 
            100                 105                 110         


Ser Phe Leu Leu Ser Ile Tyr Asn Glu His Gly Ile Gln Gln Ile Gly 
        115                 120                 125             


Val Glu Val Gly Arg Ser Pro Val Phe Leu Phe Glu Asp His Thr Gly 
    130                 135                 140                 


Lys Pro Ala Pro Glu Asp Tyr Pro Leu Phe Arg Thr Val Asn Ile Ala 
145                 150                 155                 160 


Asp Gly Lys Trp His Arg Val Ala Ile Ser Val Glu Lys Lys Thr Val 
                165                 170                 175     


Thr Met Ile Val Asp Cys Lys Lys Lys Thr Thr Lys Pro Leu Asp Arg 
            180                 185                 190         


Ser Glu Arg Ala Ile Val Asp Thr Asn Gly Ile Thr Val Phe Gly Thr 
        195                 200                 205             


Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Ile Gln Gln Phe Leu 
    210                 215                 220                 


Ile Thr Gly Asp Pro Lys Ala Ala Tyr Asp Tyr Cys Glu His Tyr Ser 
225                 230                 235                 240 


Pro Asp Cys Asp Ser Ser Ala Pro Lys Ala Ala Gln Ala Gln Glu Pro 
                245                 250                 255     


Gln Ile Asp Glu Tyr Ala Pro Glu Asp Ile Ile Glu Tyr Asp Tyr Glu 
            260                 265                 270         


Tyr Gly Glu Ala Glu Tyr Lys Glu Ala Glu Ser Val Thr Glu Gly Pro 
        275                 280                 285             


Thr Val Thr Glu Glu Thr Ile Ala Gln Thr Glu Lys Lys Lys Ser Asn 
    290                 295                 300                 


Phe Lys Lys Lys Met Arg Thr Val Ala Thr Lys Ser Lys Glu Lys Ser 
305                 310                 315                 320 


Lys Lys Phe Thr Pro Pro Lys Ser Glu Lys Phe Ser Ser Lys Lys Lys 
                325                 330                 335     


Lys Ser Tyr Gln Ala Ser Ala Lys Ala Lys Leu Gly Val Lys Ala Asn 
            340                 345                 350         


Ile Val Asp Asp Phe Gln Glu Tyr Asn Tyr Gly Thr Met Glu Ser Tyr 
        355                 360                 365             


Gln Thr Glu Ala Pro Arg His Val Ser Gly Thr Asn Glu Pro Asn Pro 
    370                 375                 380                 


Val Glu Glu Ile Phe Thr Glu Glu Tyr Leu Thr Gly Glu Asp Tyr Asp 
385                 390                 395                 400 


Ser Gln Arg Lys Asn Ser Glu Asp Thr Leu Tyr Glu Asn Lys Glu Ile 
                405                 410                 415     


Asp Gly Arg Asp Ser Asp Leu Leu Val Asp Gly Asp Leu Gly Glu Tyr 
            420                 425                 430         


Asp Phe Tyr Glu Tyr Lys Glu Tyr Glu Asp Lys Pro Thr Ser Pro Pro 
        435                 440                 445             


Asn Glu Glu Phe Gly Pro Gly Val Pro Ala Glu Thr Asp Ile Thr Glu 
    450                 455                 460                 


Thr Ser Ile Asn Gly His Gly Ala Tyr Gly Glu Lys Gly Gln Lys Gly 
465                 470                 475                 480 


Glu Pro Ala Val Val Glu Pro Gly Met Leu Val Glu Gly Pro Pro Gly 
                485                 490                 495     


Pro Ala Gly Pro Ala Gly Ile Met Gly Pro Pro Gly Leu Gln Gly Pro 
            500                 505                 510         


Thr Gly Pro Pro Gly Asp Pro Gly Asp Arg Gly Pro Pro Gly Arg Pro 
        515                 520                 525             


Gly Leu Pro Gly Ala Asp Gly Leu Pro Gly Pro Pro Gly Thr Met Leu 
    530                 535                 540                 


Met Leu Pro Phe Arg Tyr Gly Gly Asp Gly Ser Lys Gly Pro Thr Ile 
545                 550                 555                 560 


Ser Ala Gln Glu Ala Gln Ala Gln Ala Ile Leu Gln Gln Ala Arg Ile 
                565                 570                 575     


Ala Leu Arg Gly Pro Pro Gly Pro Met Gly Leu Thr Gly Arg Pro Gly 
            580                 585                 590         


Pro Val Gly Gly Pro Gly Ser Ser Gly Ala Lys Gly Glu Ser Gly Asp 
        595                 600                 605             


Pro Gly Pro Gln Gly Pro Arg Gly Val Gln Gly Pro Pro Gly Pro Thr 
    610                 615                 620                 


Gly Lys Pro Gly Lys Arg Gly Arg Pro Gly Ala Asp Gly Gly Arg Gly 
625                 630                 635                 640 


Met Pro Gly Glu Pro Gly Ala Lys Gly Asp Arg Gly Phe Asp Gly Leu 
                645                 650                 655     


Pro Gly Leu Pro Gly Asp Lys Gly His Arg Gly Glu Arg Gly Pro Gln 
            660                 665                 670         


Gly Pro Pro Gly Pro Pro Gly Asp Asp Gly Met Arg Gly Glu Asp Gly 
        675                 680                 685             


Glu Ile Gly Pro Arg Gly Leu Pro Gly Glu Ala Gly Pro Arg Gly Leu 
    690                 695                 700                 


Leu Gly Pro Arg Gly Thr Pro Gly Ala Pro Gly Gln Pro Gly Met Ala 
705                 710                 715                 720 


Gly Val Asp Gly Pro Pro Gly Pro Lys Gly Asn Met Gly Pro Gln Gly 
                725                 730                 735     


Glu Pro Gly Pro Pro Gly Gln Gln Gly Asn Pro Gly Pro Gln Gly Leu 
            740                 745                 750         


Pro Gly Pro Gln Gly Pro Ile Gly Pro Pro Gly Glu Lys Met Cys Cys 
        755                 760                 765             


Asn Leu Ser Phe Gly Ile Leu Ile Pro Leu Gln Lys 
    770                 775                 780 


<210>  3211
<211>  570
<212>  PRT
<213>  Homo Sapiens

<400>  3211

Met Glu Pro Trp Ser Ser Arg Trp Lys Thr Lys Arg Trp Leu Trp Asp 
1               5                   10                  15      


Phe Thr Val Thr Thr Leu Ala Leu Thr Phe Leu Phe Gln Ala Arg Glu 
            20                  25                  30          


Val Arg Gly Ala Ala Pro Val Asp Val Leu Lys Ala Leu Asp Phe His 
        35                  40                  45              


Asn Ser Pro Glu Gly Ile Ser Lys Thr Thr Gly Phe Cys Thr Asn Arg 
    50                  55                  60                  


Lys Asn Ser Lys Gly Ser Asp Thr Ala Tyr Arg Val Ser Lys Gln Ala 
65                  70                  75                  80  


Gln Leu Ser Ala Pro Thr Lys Gln Leu Phe Pro Gly Gly Thr Phe Pro 
                85                  90                  95      


Glu Asp Phe Ser Ile Leu Phe Thr Val Lys Pro Lys Lys Gly Ile Gln 
            100                 105                 110         


Ser Phe Leu Leu Ser Ile Tyr Asn Glu His Gly Ile Gln Gln Ile Gly 
        115                 120                 125             


Val Glu Val Gly Arg Ser Pro Val Phe Leu Phe Glu Asp His Thr Gly 
    130                 135                 140                 


Lys Pro Ala Pro Glu Asp Tyr Pro Leu Phe Arg Thr Val Asn Ile Ala 
145                 150                 155                 160 


Asp Gly Lys Trp His Arg Val Ala Ile Ser Val Glu Lys Lys Thr Val 
                165                 170                 175     


Thr Met Ile Val Asp Cys Lys Lys Lys Thr Thr Lys Pro Leu Asp Arg 
            180                 185                 190         


Ser Glu Arg Ala Ile Val Asp Thr Asn Gly Ile Thr Val Phe Gly Thr 
        195                 200                 205             


Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Ile Gln Gln Phe Leu 
    210                 215                 220                 


Ile Thr Gly Asp Pro Lys Ala Ala Tyr Asp Tyr Cys Glu His Tyr Ser 
225                 230                 235                 240 


Pro Asp Cys Asp Ser Ser Ala Pro Lys Ala Ala Gln Ala Gln Glu Pro 
                245                 250                 255     


Gln Ile Asp Glu Lys Lys Lys Ser Asn Phe Lys Lys Lys Met Arg Thr 
            260                 265                 270         


Val Ala Thr Lys Ser Lys Glu Lys Ser Lys Lys Phe Thr Pro Pro Lys 
        275                 280                 285             


Ser Glu Lys Phe Ser Ser Lys Lys Lys Lys Ser Tyr Gln Ala Ser Ala 
    290                 295                 300                 


Lys Ala Lys Leu Gly Val Lys Ala Asn Ile Val Asp Asp Phe Gln Glu 
305                 310                 315                 320 


Tyr Asn Tyr Gly Thr Met Glu Ser Tyr Gln Thr Glu Ala Pro Arg His 
                325                 330                 335     


Val Ser Gly Thr Asn Glu Pro Asn Pro Val Glu Glu Ile Phe Thr Glu 
            340                 345                 350         


Glu Tyr Leu Thr Gly Glu Asp Tyr Asp Ser Gln Arg Lys Asn Ser Glu 
        355                 360                 365             


Asp Thr Leu Tyr Glu Asn Lys Glu Ile Asp Gly Arg Asp Ser Asp Leu 
    370                 375                 380                 


Leu Val Asp Gly Asp Leu Gly Glu Tyr Asp Phe Tyr Glu Tyr Lys Glu 
385                 390                 395                 400 


Tyr Glu Asp Lys Pro Thr Ser Pro Pro Asn Glu Glu Phe Gly Pro Gly 
                405                 410                 415     


Val Pro Ala Glu Thr Asp Ile Thr Glu Thr Ser Ile Asn Gly His Gly 
            420                 425                 430         


Ala Tyr Gly Glu Lys Gly Gln Lys Gly Glu Pro Ala Val Val Glu Pro 
        435                 440                 445             


Gly Met Leu Val Glu Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly Ile 
    450                 455                 460                 


Met Gly Pro Pro Gly Leu Gln Gly Pro Thr Gly Pro Pro Gly Asp Pro 
465                 470                 475                 480 


Gly Asp Arg Gly Pro Pro Gly Arg Pro Gly Leu Pro Gly Ala Asp Gly 
                485                 490                 495     


Leu Pro Gly Pro Pro Gly Thr Met Leu Met Leu Pro Phe Arg Tyr Gly 
            500                 505                 510         


Gly Asp Gly Ser Lys Gly Pro Thr Ile Ser Ala Gln Glu Ala Gln Ala 
        515                 520                 525             


Gln Ala Ile Leu Gln Gln Ala Arg Ile Ala Leu Arg Gly Pro Pro Gly 
    530                 535                 540                 


Pro Met Gly Leu Thr Gly Arg Pro Gly Pro Val Gly Gly Pro Gly Ser 
545                 550                 555                 560 


Ser Gly Ala Lys Gly Glu Ser Gly Asp Pro 
                565                 570 


<210>  3212
<211>  1690
<212>  PRT
<213>  Homo Sapiens

<400>  3212

Met Glu Pro Trp Ser Ser Arg Trp Lys Thr Lys Arg Trp Leu Trp Asp 
1               5                   10                  15      


Phe Thr Val Thr Thr Leu Ala Leu Thr Phe Leu Phe Gln Ala Arg Glu 
            20                  25                  30          


Val Arg Gly Ala Ala Pro Val Asp Val Leu Lys Ala Leu Asp Phe His 
        35                  40                  45              


Asn Ser Pro Glu Gly Ile Ser Lys Thr Thr Gly Phe Cys Thr Asn Arg 
    50                  55                  60                  


Lys Asn Ser Lys Gly Ser Asp Thr Ala Tyr Arg Val Ser Lys Gln Ala 
65                  70                  75                  80  


Gln Leu Ser Ala Pro Thr Lys Gln Leu Phe Pro Gly Gly Thr Phe Pro 
                85                  90                  95      


Glu Asp Phe Ser Ile Leu Phe Thr Val Lys Pro Lys Lys Gly Ile Gln 
            100                 105                 110         


Ser Phe Leu Leu Ser Ile Tyr Asn Glu His Gly Ile Gln Gln Ile Gly 
        115                 120                 125             


Val Glu Val Gly Arg Ser Pro Val Phe Leu Phe Glu Asp His Thr Gly 
    130                 135                 140                 


Lys Pro Ala Pro Glu Asp Tyr Pro Leu Phe Arg Thr Val Asn Ile Ala 
145                 150                 155                 160 


Asp Gly Lys Trp His Arg Val Ala Ile Ser Val Glu Lys Lys Thr Val 
                165                 170                 175     


Thr Met Ile Val Asp Cys Lys Lys Lys Thr Thr Lys Pro Leu Asp Arg 
            180                 185                 190         


Ser Glu Arg Ala Ile Val Asp Thr Asn Gly Ile Thr Val Phe Gly Thr 
        195                 200                 205             


Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Ile Gln Gln Phe Leu 
    210                 215                 220                 


Ile Thr Gly Asp Pro Lys Ala Ala Tyr Asp Tyr Cys Glu His Tyr Ser 
225                 230                 235                 240 


Pro Asp Cys Asp Ser Ser Ala Pro Lys Ala Ala Gln Ala Gln Glu Pro 
                245                 250                 255     


Gln Ile Asp Glu Tyr Ala Pro Glu Asp Ile Ile Glu Tyr Asp Tyr Glu 
            260                 265                 270         


Tyr Gly Glu Ala Glu Tyr Lys Glu Ala Glu Ser Val Thr Glu Gly Pro 
        275                 280                 285             


Thr Val Thr Glu Glu Thr Ile Ala Gln Thr Glu Ile Asn Gly His Gly 
    290                 295                 300                 


Ala Tyr Gly Glu Lys Gly Gln Lys Gly Glu Pro Ala Val Val Glu Pro 
305                 310                 315                 320 


Gly Met Leu Val Glu Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly Ile 
                325                 330                 335     


Met Gly Pro Pro Gly Leu Gln Gly Pro Thr Gly Pro Pro Gly Asp Pro 
            340                 345                 350         


Gly Asp Arg Gly Pro Pro Gly Arg Pro Gly Leu Pro Gly Ala Asp Gly 
        355                 360                 365             


Leu Pro Gly Pro Pro Gly Thr Met Leu Met Leu Pro Phe Arg Tyr Gly 
    370                 375                 380                 


Gly Asp Gly Ser Lys Gly Pro Thr Ile Ser Ala Gln Glu Ala Gln Ala 
385                 390                 395                 400 


Gln Ala Ile Leu Gln Gln Ala Arg Ile Ala Leu Arg Gly Pro Pro Gly 
                405                 410                 415     


Pro Met Gly Leu Thr Gly Arg Pro Gly Pro Val Gly Gly Pro Gly Ser 
            420                 425                 430         


Ser Gly Ala Lys Gly Glu Ser Gly Asp Pro Gly Pro Gln Gly Pro Arg 
        435                 440                 445             


Gly Val Gln Gly Pro Pro Gly Pro Thr Gly Lys Pro Gly Lys Arg Gly 
    450                 455                 460                 


Arg Pro Gly Ala Asp Gly Gly Arg Gly Met Pro Gly Glu Pro Gly Ala 
465                 470                 475                 480 


Lys Gly Asp Arg Gly Phe Asp Gly Leu Pro Gly Leu Pro Gly Asp Lys 
                485                 490                 495     


Gly His Arg Gly Glu Arg Gly Pro Gln Gly Pro Pro Gly Pro Pro Gly 
            500                 505                 510         


Asp Asp Gly Met Arg Gly Glu Asp Gly Glu Ile Gly Pro Arg Gly Leu 
        515                 520                 525             


Pro Gly Glu Ala Gly Pro Arg Gly Leu Leu Gly Pro Arg Gly Thr Pro 
    530                 535                 540                 


Gly Ala Pro Gly Gln Pro Gly Met Ala Gly Val Asp Gly Pro Pro Gly 
545                 550                 555                 560 


Pro Lys Gly Asn Met Gly Pro Gln Gly Glu Pro Gly Pro Pro Gly Gln 
                565                 570                 575     


Gln Gly Asn Pro Gly Pro Gln Gly Leu Pro Gly Pro Gln Gly Pro Ile 
            580                 585                 590         


Gly Pro Pro Gly Glu Lys Gly Pro Gln Gly Lys Pro Gly Leu Ala Gly 
        595                 600                 605             


Leu Pro Gly Ala Asp Gly Pro Pro Gly His Pro Gly Lys Glu Gly Gln 
    610                 615                 620                 


Ser Gly Glu Lys Gly Ala Leu Gly Pro Pro Gly Pro Gln Gly Pro Ile 
625                 630                 635                 640 


Gly Tyr Pro Gly Pro Arg Gly Val Lys Gly Ala Asp Gly Val Arg Gly 
                645                 650                 655     


Leu Lys Gly Ser Lys Gly Glu Lys Gly Glu Asp Gly Phe Pro Gly Phe 
            660                 665                 670         


Lys Gly Asp Met Gly Leu Lys Gly Asp Arg Gly Glu Val Gly Gln Ile 
        675                 680                 685             


Gly Pro Arg Gly Glu Asp Gly Pro Glu Gly Pro Lys Gly Arg Ala Gly 
    690                 695                 700                 


Pro Thr Gly Asp Pro Gly Pro Ser Gly Gln Ala Gly Glu Lys Gly Lys 
705                 710                 715                 720 


Leu Gly Val Pro Gly Leu Pro Gly Tyr Pro Gly Arg Gln Gly Pro Lys 
                725                 730                 735     


Gly Ser Thr Gly Phe Pro Gly Phe Pro Gly Ala Asn Gly Glu Lys Gly 
            740                 745                 750         


Ala Arg Gly Val Ala Gly Lys Pro Gly Pro Arg Gly Gln Arg Gly Pro 
        755                 760                 765             


Thr Gly Pro Arg Gly Ser Arg Gly Ala Arg Gly Pro Thr Gly Lys Pro 
    770                 775                 780                 


Gly Pro Lys Gly Thr Ser Gly Gly Asp Gly Pro Pro Gly Pro Pro Gly 
785                 790                 795                 800 


Glu Arg Gly Pro Gln Gly Pro Gln Gly Pro Val Gly Phe Pro Gly Pro 
                805                 810                 815     


Lys Gly Pro Pro Gly Pro Pro Gly Lys Asp Gly Leu Pro Gly His Pro 
            820                 825                 830         


Gly Gln Arg Gly Glu Thr Gly Phe Gln Gly Lys Thr Gly Pro Pro Gly 
        835                 840                 845             


Pro Gly Gly Val Val Gly Pro Gln Gly Pro Thr Gly Glu Thr Gly Pro 
    850                 855                 860                 


Ile Gly Glu Arg Gly His Pro Gly Pro Pro Gly Pro Pro Gly Glu Gln 
865                 870                 875                 880 


Gly Leu Pro Gly Ala Ala Gly Lys Glu Gly Ala Lys Gly Asp Pro Gly 
                885                 890                 895     


Pro Gln Gly Ile Ser Gly Lys Asp Gly Pro Ala Gly Leu Arg Gly Phe 
            900                 905                 910         


Pro Gly Glu Arg Gly Leu Pro Gly Ala Gln Gly Ala Pro Gly Leu Lys 
        915                 920                 925             


Gly Gly Glu Gly Pro Gln Gly Pro Pro Gly Pro Val Gly Ser Pro Gly 
    930                 935                 940                 


Glu Arg Gly Ser Ala Gly Thr Ala Gly Pro Ile Gly Leu Pro Gly Arg 
945                 950                 955                 960 


Pro Gly Pro Gln Gly Pro Pro Gly Pro Ala Gly Glu Lys Gly Ala Pro 
                965                 970                 975     


Gly Glu Lys Gly Pro Gln Gly Pro Ala Gly Arg Asp Gly Val Gln Gly 
            980                 985                 990         


Pro Val Gly Leu Pro Gly Pro Ala  Gly Pro Ala Gly Ser  Pro Gly Glu 
        995                 1000                 1005             


Asp Gly  Asp Lys Gly Glu Ile  Gly Glu Pro Gly Gln  Lys Gly Ser 
    1010                 1015                 1020             


Lys Gly  Asp Lys Gly Glu Asn  Gly Pro Pro Gly Pro  Pro Gly Leu 
    1025                 1030                 1035             


Gln Gly  Pro Val Gly Ala Pro  Gly Ile Ala Gly Gly  Asp Gly Glu 
    1040                 1045                 1050             


Pro Gly  Pro Arg Gly Gln Gln  Gly Met Phe Gly Gln  Lys Gly Asp 
    1055                 1060                 1065             


Glu Gly  Ala Arg Gly Phe Pro  Gly Pro Pro Gly Pro  Ile Gly Leu 
    1070                 1075                 1080             


Gln Gly  Leu Pro Gly Pro Pro  Gly Glu Lys Gly Glu  Asn Gly Asp 
    1085                 1090                 1095             


Val Gly  Pro Met Gly Pro Pro  Gly Pro Pro Gly Pro  Arg Gly Pro 
    1100                 1105                 1110             


Gln Gly  Pro Asn Gly Ala Asp  Gly Pro Gln Gly Pro  Pro Gly Ser 
    1115                 1120                 1125             


Val Gly  Ser Val Gly Gly Val  Gly Glu Lys Gly Glu  Pro Gly Glu 
    1130                 1135                 1140             


Ala Gly  Asn Pro Gly Pro Pro  Gly Glu Ala Gly Val  Gly Gly Pro 
    1145                 1150                 1155             


Lys Gly  Glu Arg Gly Glu Lys  Gly Glu Ala Gly Pro  Pro Gly Ala 
    1160                 1165                 1170             


Ala Gly  Pro Pro Gly Ala Lys  Gly Pro Pro Gly Asp  Asp Gly Pro 
    1175                 1180                 1185             


Lys Gly  Asn Pro Gly Pro Val  Gly Phe Pro Gly Asp  Pro Gly Pro 
    1190                 1195                 1200             


Pro Gly  Glu Pro Gly Pro Ala  Gly Gln Asp Gly Val  Gly Gly Asp 
    1205                 1210                 1215             


Lys Gly  Glu Asp Gly Asp Pro  Gly Gln Pro Gly Pro  Pro Gly Pro 
    1220                 1225                 1230             


Ser Gly  Glu Ala Gly Pro Pro  Gly Pro Pro Gly Lys  Arg Gly Pro 
    1235                 1240                 1245             


Pro Gly  Ala Ala Gly Ala Glu  Gly Arg Gln Gly Glu  Lys Gly Ala 
    1250                 1255                 1260             


Lys Gly  Glu Ala Gly Ala Glu  Gly Pro Pro Gly Lys  Thr Gly Pro 
    1265                 1270                 1275             


Val Gly  Pro Gln Gly Pro Ala  Gly Lys Pro Gly Pro  Glu Gly Leu 
    1280                 1285                 1290             


Arg Gly  Ile Pro Gly Pro Val  Gly Glu Gln Gly Leu  Pro Gly Ala 
    1295                 1300                 1305             


Ala Gly  Gln Asp Gly Pro Pro  Gly Pro Met Gly Pro  Pro Gly Leu 
    1310                 1315                 1320             


Pro Gly  Leu Lys Gly Asp Pro  Gly Ser Lys Gly Glu  Lys Gly His 
    1325                 1330                 1335             


Pro Gly  Leu Ile Gly Leu Ile  Gly Pro Pro Gly Glu  Gln Gly Glu 
    1340                 1345                 1350             


Lys Gly  Asp Arg Gly Leu Pro  Gly Thr Gln Gly Ser  Pro Gly Ala 
    1355                 1360                 1365             


Lys Gly  Asp Gly Gly Ile Pro  Gly Pro Ala Gly Pro  Leu Gly Pro 
    1370                 1375                 1380             


Pro Gly  Pro Pro Gly Leu Pro  Gly Pro Gln Gly Pro  Lys Gly Asn 
    1385                 1390                 1395             


Lys Gly  Ser Thr Gly Pro Ala  Gly Gln Lys Gly Asp  Ser Gly Leu 
    1400                 1405                 1410             


Pro Gly  Pro Pro Gly Ser Pro  Gly Pro Pro Gly Glu  Val Ile Gln 
    1415                 1420                 1425             


Pro Leu  Pro Ile Leu Ser Ser  Lys Lys Thr Arg Arg  His Thr Glu 
    1430                 1435                 1440             


Gly Met  Gln Ala Asp Ala Asp  Asp Asn Ile Leu Asp  Tyr Ser Asp 
    1445                 1450                 1455             


Gly Met  Glu Glu Ile Phe Gly  Ser Leu Asn Ser Leu  Lys Gln Asp 
    1460                 1465                 1470             


Ile Glu  His Met Lys Phe Pro  Met Gly Thr Gln Thr  Asn Pro Ala 
    1475                 1480                 1485             


Arg Thr  Cys Lys Asp Leu Gln  Leu Ser His Pro Asp  Phe Pro Asp 
    1490                 1495                 1500             


Gly Glu  Tyr Trp Ile Asp Pro  Asn Gln Gly Cys Ser  Gly Asp Ser 
    1505                 1510                 1515             


Phe Lys  Val Tyr Cys Asn Phe  Thr Ser Gly Gly Glu  Thr Cys Ile 
    1520                 1525                 1530             


Tyr Pro  Asp Lys Lys Ser Glu  Gly Val Arg Ile Ser  Ser Trp Pro 
    1535                 1540                 1545             


Lys Glu  Lys Pro Gly Ser Trp  Phe Ser Glu Phe Lys  Arg Gly Lys 
    1550                 1555                 1560             


Leu Leu  Ser Tyr Leu Asp Val  Glu Gly Asn Ser Ile  Asn Met Val 
    1565                 1570                 1575             


Gln Met  Thr Phe Leu Lys Leu  Leu Thr Ala Ser Ala  Arg Gln Asn 
    1580                 1585                 1590             


Phe Thr  Tyr His Cys His Gln  Ser Ala Ala Trp Tyr  Asp Val Ser 
    1595                 1600                 1605             


Ser Gly  Ser Tyr Asp Lys Ala  Leu Arg Phe Leu Gly  Ser Asn Asp 
    1610                 1615                 1620             


Glu Glu  Met Ser Tyr Asp Asn  Asn Pro Phe Ile Lys  Thr Leu Tyr 
    1625                 1630                 1635             


Asp Gly  Cys Ala Ser Arg Lys  Gly Tyr Glu Lys Thr  Val Ile Glu 
    1640                 1645                 1650             


Ile Asn  Thr Pro Lys Ile Asp  Gln Val Pro Ile Val  Asp Val Met 
    1655                 1660                 1665             


Ile Asn  Asp Phe Gly Asp Gln  Asn Gln Lys Phe Gly  Phe Glu Val 
    1670                 1675                 1680             


Gly Pro  Val Cys Phe Leu Gly  
    1685                 1690 


<210>  3213
<211>  736
<212>  PRT
<213>  Homo Sapiens

<400>  3213

Met Glu Pro Trp Ser Ser Arg Trp Lys Thr Lys Arg Trp Leu Trp Asp 
1               5                   10                  15      


Phe Thr Val Thr Thr Leu Ala Leu Thr Phe Leu Phe Gln Ala Arg Glu 
            20                  25                  30          


Val Arg Gly Ala Ala Pro Val Asp Val Leu Lys Ala Leu Asp Phe His 
        35                  40                  45              


Asn Ser Pro Glu Gly Ile Ser Lys Thr Thr Gly Phe Cys Thr Asn Arg 
    50                  55                  60                  


Lys Asn Ser Lys Gly Ser Asp Thr Ala Tyr Arg Val Ser Lys Gln Ala 
65                  70                  75                  80  


Gln Leu Ser Ala Pro Thr Lys Gln Leu Phe Pro Gly Gly Thr Phe Pro 
                85                  90                  95      


Glu Asp Phe Ser Ile Leu Phe Thr Val Lys Pro Lys Lys Gly Ile Gln 
            100                 105                 110         


Ser Phe Leu Leu Ser Ile Tyr Asn Glu His Gly Ile Gln Gln Ile Gly 
        115                 120                 125             


Val Glu Val Gly Arg Ser Pro Val Phe Leu Phe Glu Asp His Thr Gly 
    130                 135                 140                 


Lys Pro Ala Pro Glu Asp Tyr Pro Leu Phe Arg Thr Val Asn Ile Ala 
145                 150                 155                 160 


Asp Gly Lys Trp His Arg Val Ala Ile Ser Val Glu Lys Lys Thr Val 
                165                 170                 175     


Thr Met Ile Val Asp Cys Lys Lys Lys Thr Thr Lys Pro Leu Asp Arg 
            180                 185                 190         


Ser Glu Arg Ala Ile Val Asp Thr Asn Gly Ile Thr Val Phe Gly Thr 
        195                 200                 205             


Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Ile Gln Gln Phe Leu 
    210                 215                 220                 


Ile Thr Gly Asp Pro Lys Ala Ala Tyr Asp Tyr Cys Glu His Tyr Ser 
225                 230                 235                 240 


Pro Asp Cys Asp Ser Ser Ala Pro Lys Ala Ala Gln Ala Gln Glu Pro 
                245                 250                 255     


Gln Ile Asp Glu Tyr Ala Pro Glu Asp Ile Ile Glu Tyr Asp Tyr Glu 
            260                 265                 270         


Tyr Gly Glu Ala Glu Tyr Lys Glu Ala Glu Ser Val Thr Glu Gly Pro 
        275                 280                 285             


Thr Val Thr Glu Glu Thr Ile Ala Gln Thr Glu Ala Asn Ile Val Asp 
    290                 295                 300                 


Asp Phe Gln Glu Tyr Asn Tyr Gly Thr Met Glu Ser Tyr Gln Thr Glu 
305                 310                 315                 320 


Ala Pro Arg His Val Ser Gly Thr Asn Glu Pro Asn Pro Val Glu Glu 
                325                 330                 335     


Ile Phe Thr Glu Glu Tyr Leu Thr Gly Glu Asp Tyr Asp Ser Gln Arg 
            340                 345                 350         


Lys Asn Ser Glu Asp Thr Leu Tyr Glu Asn Lys Glu Ile Asp Gly Arg 
        355                 360                 365             


Asp Ser Asp Leu Leu Val Asp Gly Asp Leu Gly Glu Tyr Asp Phe Tyr 
    370                 375                 380                 


Glu Tyr Lys Glu Tyr Glu Asp Lys Pro Thr Ser Pro Pro Asn Glu Glu 
385                 390                 395                 400 


Phe Gly Pro Gly Val Pro Ala Glu Thr Asp Ile Thr Glu Thr Ser Ile 
                405                 410                 415     


Asn Gly His Gly Ala Tyr Gly Glu Lys Gly Gln Lys Gly Glu Pro Ala 
            420                 425                 430         


Val Val Glu Pro Gly Met Leu Val Glu Gly Pro Pro Gly Pro Ala Gly 
        435                 440                 445             


Pro Ala Gly Ile Met Gly Pro Pro Gly Leu Gln Gly Pro Thr Gly Pro 
    450                 455                 460                 


Pro Gly Asp Pro Gly Asp Arg Gly Pro Pro Gly Arg Pro Gly Leu Pro 
465                 470                 475                 480 


Gly Ala Asp Gly Leu Pro Gly Pro Pro Gly Thr Met Leu Met Leu Pro 
                485                 490                 495     


Phe Arg Tyr Gly Gly Asp Gly Ser Lys Gly Pro Thr Ile Ser Ala Gln 
            500                 505                 510         


Glu Ala Gln Ala Gln Ala Ile Leu Gln Gln Ala Arg Ile Ala Leu Arg 
        515                 520                 525             


Gly Pro Pro Gly Pro Met Gly Leu Thr Gly Arg Pro Gly Pro Val Gly 
    530                 535                 540                 


Gly Pro Gly Ser Ser Gly Ala Lys Gly Glu Ser Gly Asp Pro Gly Pro 
545                 550                 555                 560 


Gln Gly Pro Arg Gly Val Gln Gly Pro Pro Gly Pro Thr Gly Lys Pro 
                565                 570                 575     


Gly Lys Arg Gly Arg Pro Gly Ala Asp Gly Gly Arg Gly Met Pro Gly 
            580                 585                 590         


Glu Pro Gly Ala Lys Gly Asp Arg Gly Phe Asp Gly Leu Pro Gly Leu 
        595                 600                 605             


Pro Gly Asp Lys Gly His Arg Gly Glu Arg Gly Pro Gln Gly Pro Pro 
    610                 615                 620                 


Gly Pro Pro Gly Asp Asp Gly Met Arg Gly Glu Asp Gly Glu Ile Gly 
625                 630                 635                 640 


Pro Arg Gly Leu Pro Gly Glu Ala Gly Pro Arg Gly Leu Leu Gly Pro 
                645                 650                 655     


Arg Gly Thr Pro Gly Ala Pro Gly Gln Pro Gly Met Ala Gly Val Asp 
            660                 665                 670         


Gly Pro Pro Gly Pro Lys Gly Asn Met Gly Pro Gln Gly Glu Pro Gly 
        675                 680                 685             


Pro Pro Gly Gln Gln Gly Asn Pro Gly Pro Gln Gly Leu Pro Gly Pro 
    690                 695                 700                 


Gln Gly Pro Ile Gly Pro Pro Gly Glu Lys Val Ser Tyr Ser Val Val 
705                 710                 715                 720 


Leu Val Lys Pro Gly Glu His Val Cys Phe Ser Asn Leu Arg Gln Val 
                725                 730                 735     


<210>  3214
<211>  729
<212>  PRT
<213>  Homo Sapiens

<400>  3214

Met Glu Pro Trp Ser Ser Arg Trp Lys Thr Lys Arg Trp Leu Trp Asp 
1               5                   10                  15      


Phe Thr Val Thr Thr Leu Ala Leu Thr Phe Leu Phe Gln Ala Arg Glu 
            20                  25                  30          


Val Arg Gly Ala Ala Pro Val Asp Val Leu Lys Ala Leu Asp Phe His 
        35                  40                  45              


Asn Ser Pro Glu Gly Ile Ser Lys Thr Thr Gly Phe Cys Thr Asn Arg 
    50                  55                  60                  


Lys Asn Ser Lys Gly Ser Asp Thr Ala Tyr Arg Val Ser Lys Gln Ala 
65                  70                  75                  80  


Gln Leu Ser Ala Pro Thr Lys Gln Leu Phe Pro Gly Gly Thr Phe Pro 
                85                  90                  95      


Glu Asp Phe Ser Ile Leu Phe Thr Val Lys Pro Lys Lys Gly Ile Gln 
            100                 105                 110         


Ser Phe Leu Leu Ser Ile Tyr Asn Glu His Gly Ile Gln Gln Ile Gly 
        115                 120                 125             


Val Glu Val Gly Arg Ser Pro Val Phe Leu Phe Glu Asp His Thr Gly 
    130                 135                 140                 


Lys Pro Ala Pro Glu Asp Tyr Pro Leu Phe Arg Thr Val Asn Ile Ala 
145                 150                 155                 160 


Asp Gly Lys Trp His Arg Val Ala Ile Ser Val Glu Lys Lys Thr Val 
                165                 170                 175     


Thr Met Ile Val Asp Cys Lys Lys Lys Thr Thr Lys Pro Leu Asp Arg 
            180                 185                 190         


Ser Glu Arg Ala Ile Val Asp Thr Asn Gly Ile Thr Val Phe Gly Thr 
        195                 200                 205             


Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Ile Gln Gln Phe Leu 
    210                 215                 220                 


Ile Thr Gly Asp Pro Lys Ala Ala Tyr Asp Tyr Cys Glu His Tyr Ser 
225                 230                 235                 240 


Pro Asp Cys Asp Ser Ser Ala Pro Lys Ala Ala Gln Ala Gln Glu Pro 
                245                 250                 255     


Gln Ile Asp Glu Tyr Ala Pro Glu Asp Ile Ile Glu Tyr Asp Tyr Glu 
            260                 265                 270         


Tyr Gly Glu Ala Glu Tyr Lys Glu Ala Glu Ser Val Thr Glu Gly Pro 
        275                 280                 285             


Thr Val Thr Glu Glu Thr Ile Ala Gln Thr Glu Ala Asn Ile Val Asp 
    290                 295                 300                 


Asp Phe Gln Glu Tyr Asn Tyr Gly Thr Met Glu Ser Tyr Gln Thr Glu 
305                 310                 315                 320 


Ala Pro Arg His Val Ser Gly Thr Asn Glu Pro Asn Pro Val Glu Glu 
                325                 330                 335     


Ile Phe Thr Glu Glu Tyr Leu Thr Gly Glu Asp Tyr Asp Ser Gln Arg 
            340                 345                 350         


Lys Asn Ser Glu Asp Thr Leu Tyr Glu Asn Lys Glu Ile Asp Gly Arg 
        355                 360                 365             


Asp Ser Asp Leu Leu Val Asp Gly Asp Leu Gly Glu Tyr Asp Phe Tyr 
    370                 375                 380                 


Glu Tyr Lys Glu Tyr Glu Asp Lys Pro Thr Ser Pro Pro Asn Glu Glu 
385                 390                 395                 400 


Phe Gly Pro Gly Val Pro Ala Glu Thr Asp Ile Thr Glu Thr Ser Ile 
                405                 410                 415     


Asn Gly His Gly Ala Tyr Gly Glu Lys Gly Gln Lys Gly Glu Pro Ala 
            420                 425                 430         


Val Val Glu Pro Gly Met Leu Val Glu Gly Pro Pro Gly Pro Ala Gly 
        435                 440                 445             


Pro Ala Gly Ile Met Gly Pro Pro Gly Leu Gln Gly Pro Thr Gly Pro 
    450                 455                 460                 


Pro Gly Asp Pro Gly Asp Arg Gly Pro Pro Gly Arg Pro Gly Leu Pro 
465                 470                 475                 480 


Gly Ala Asp Gly Leu Pro Gly Pro Pro Gly Thr Met Leu Met Leu Pro 
                485                 490                 495     


Phe Arg Tyr Gly Gly Asp Gly Ser Lys Gly Pro Thr Ile Ser Ala Gln 
            500                 505                 510         


Glu Ala Gln Ala Gln Ala Ile Leu Gln Gln Ala Arg Ile Ala Leu Arg 
        515                 520                 525             


Gly Pro Pro Gly Pro Met Gly Leu Thr Gly Arg Pro Gly Pro Val Gly 
    530                 535                 540                 


Gly Pro Gly Ser Ser Gly Ala Lys Gly Glu Ser Gly Asp Pro Gly Pro 
545                 550                 555                 560 


Gln Gly Pro Arg Gly Val Gln Gly Pro Pro Gly Pro Thr Gly Lys Pro 
                565                 570                 575     


Gly Lys Arg Gly Arg Pro Gly Ala Asp Gly Gly Arg Gly Met Pro Gly 
            580                 585                 590         


Glu Pro Gly Ala Lys Gly Asp Arg Gly Phe Asp Gly Leu Pro Gly Leu 
        595                 600                 605             


Pro Gly Asp Lys Gly His Arg Gly Glu Arg Gly Pro Gln Gly Pro Pro 
    610                 615                 620                 


Gly Pro Pro Gly Asp Asp Gly Met Arg Gly Glu Asp Gly Glu Ile Gly 
625                 630                 635                 640 


Pro Arg Gly Leu Pro Gly Glu Ala Gly Pro Arg Gly Leu Leu Gly Pro 
                645                 650                 655     


Arg Gly Thr Pro Gly Ala Pro Gly Gln Pro Gly Met Ala Gly Val Asp 
            660                 665                 670         


Gly Pro Pro Gly Pro Lys Gly Asn Met Gly Pro Gln Gly Glu Pro Gly 
        675                 680                 685             


Pro Pro Gly Gln Gln Gly Asn Pro Gly Pro Gln Gly Leu Pro Gly Pro 
    690                 695                 700                 


Gln Gly Pro Ile Gly Pro Pro Gly Glu Lys Met Cys Cys Asn Leu Ser 
705                 710                 715                 720 


Phe Gly Ile Leu Ile Pro Leu Gln Lys 
                725                 


<210>  3215
<211>  756
<212>  PRT
<213>  Homo Sapiens

<400>  3215

Met Glu Pro Trp Ser Ser Arg Trp Lys Thr Lys Arg Trp Leu Trp Asp 
1               5                   10                  15      


Phe Thr Val Thr Thr Leu Ala Leu Thr Phe Leu Phe Gln Ala Arg Glu 
            20                  25                  30          


Val Arg Gly Ala Ala Pro Val Asp Val Leu Lys Ala Leu Asp Phe His 
        35                  40                  45              


Asn Ser Pro Glu Gly Ile Ser Lys Thr Thr Gly Phe Cys Thr Asn Arg 
    50                  55                  60                  


Lys Asn Ser Lys Gly Ser Asp Thr Ala Tyr Arg Val Ser Lys Gln Ala 
65                  70                  75                  80  


Gln Leu Ser Ala Pro Thr Lys Gln Leu Phe Pro Gly Gly Thr Phe Pro 
                85                  90                  95      


Glu Asp Phe Ser Ile Leu Phe Thr Val Lys Pro Lys Lys Gly Ile Gln 
            100                 105                 110         


Ser Phe Leu Leu Ser Ile Tyr Asn Glu His Gly Ile Gln Gln Ile Gly 
        115                 120                 125             


Val Glu Val Gly Arg Ser Pro Val Phe Leu Phe Glu Asp His Thr Gly 
    130                 135                 140                 


Lys Pro Ala Pro Glu Asp Tyr Pro Leu Phe Arg Thr Val Asn Ile Ala 
145                 150                 155                 160 


Asp Gly Lys Trp His Arg Val Ala Ile Ser Val Glu Lys Lys Thr Val 
                165                 170                 175     


Thr Met Ile Val Asp Cys Lys Lys Lys Thr Thr Lys Pro Leu Asp Arg 
            180                 185                 190         


Ser Glu Arg Ala Ile Val Asp Thr Asn Gly Ile Thr Val Phe Gly Thr 
        195                 200                 205             


Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Ile Gln Gln Phe Leu 
    210                 215                 220                 


Ile Thr Gly Asp Pro Lys Ala Ala Tyr Asp Tyr Cys Glu His Tyr Ser 
225                 230                 235                 240 


Pro Asp Cys Asp Ser Ser Ala Pro Lys Ala Ala Gln Ala Gln Glu Pro 
                245                 250                 255     


Gln Ile Asp Glu Tyr Ala Pro Glu Asp Ile Ile Glu Tyr Asp Tyr Glu 
            260                 265                 270         


Tyr Gly Glu Ala Glu Tyr Lys Glu Ala Glu Ser Val Thr Glu Gly Pro 
        275                 280                 285             


Thr Val Thr Glu Glu Thr Ile Ala Gln Thr Glu Ala Asn Ile Val Asp 
    290                 295                 300                 


Asp Phe Gln Glu Tyr Asn Tyr Gly Thr Met Glu Ser Tyr Gln Thr Glu 
305                 310                 315                 320 


Ala Pro Arg His Val Ser Gly Thr Asn Glu Pro Asn Pro Val Glu Glu 
                325                 330                 335     


Ile Phe Thr Glu Glu Tyr Leu Thr Gly Glu Asp Tyr Asp Ser Gln Arg 
            340                 345                 350         


Lys Asn Ser Glu Asp Thr Leu Tyr Glu Asn Lys Glu Ile Asp Gly Arg 
        355                 360                 365             


Asp Ser Asp Leu Leu Val Asp Gly Asp Leu Gly Glu Tyr Asp Phe Tyr 
    370                 375                 380                 


Glu Tyr Lys Glu Tyr Glu Asp Lys Pro Thr Ser Pro Pro Asn Glu Glu 
385                 390                 395                 400 


Phe Gly Pro Gly Val Pro Ala Glu Thr Asp Ile Thr Glu Thr Ser Ile 
                405                 410                 415     


Asn Gly His Gly Ala Tyr Gly Glu Lys Gly Gln Lys Gly Glu Pro Ala 
            420                 425                 430         


Val Val Glu Pro Gly Met Leu Val Glu Gly Pro Pro Gly Pro Ala Gly 
        435                 440                 445             


Pro Ala Gly Ile Met Gly Pro Pro Gly Leu Gln Gly Pro Thr Gly Pro 
    450                 455                 460                 


Pro Gly Asp Pro Gly Asp Arg Gly Pro Pro Gly Arg Pro Gly Leu Pro 
465                 470                 475                 480 


Gly Ala Asp Gly Leu Pro Gly Pro Pro Gly Thr Met Leu Met Leu Pro 
                485                 490                 495     


Phe Arg Tyr Gly Gly Asp Gly Ser Lys Gly Pro Thr Ile Ser Ala Gln 
            500                 505                 510         


Glu Ala Gln Ala Gln Ala Ile Leu Gln Gln Ala Arg Ile Ala Leu Arg 
        515                 520                 525             


Gly Pro Pro Gly Pro Met Gly Leu Thr Gly Arg Pro Gly Pro Val Gly 
    530                 535                 540                 


Gly Pro Gly Ser Ser Gly Ala Lys Gly Glu Ser Gly Asp Pro Gly Pro 
545                 550                 555                 560 


Gln Gly Pro Arg Gly Val Gln Gly Pro Pro Gly Pro Thr Gly Lys Pro 
                565                 570                 575     


Gly Lys Arg Gly Arg Pro Gly Ala Asp Gly Gly Arg Gly Met Pro Gly 
            580                 585                 590         


Glu Pro Gly Ala Lys Gly Asp Arg Gly Phe Asp Gly Leu Pro Gly Leu 
        595                 600                 605             


Pro Gly Asp Lys Gly His Arg Gly Glu Arg Gly Pro Gln Gly Pro Pro 
    610                 615                 620                 


Gly Pro Pro Gly Asp Asp Gly Met Arg Gly Glu Asp Gly Glu Ile Gly 
625                 630                 635                 640 


Pro Arg Gly Leu Pro Gly Glu Ala Gly Pro Arg Gly Leu Leu Gly Pro 
                645                 650                 655     


Arg Gly Thr Pro Gly Ala Pro Gly Gln Pro Gly Met Ala Gly Val Asp 
            660                 665                 670         


Gly Pro Pro Gly Pro Lys Gly Asn Met Gly Pro Gln Gly Glu Pro Gly 
        675                 680                 685             


Pro Pro Gly Gln Gln Gly Asn Pro Gly Pro Gln Gly Leu Pro Gly Pro 
    690                 695                 700                 


Gln Gly Pro Ile Gly Pro Pro Gly Glu Lys Val Ser Phe Ser Phe Ser 
705                 710                 715                 720 


Leu Phe Tyr Lys Lys Val Ile Lys Phe Ala Cys Asp Lys Arg Phe Val 
                725                 730                 735     


Gly Arg His Asp Glu Arg Lys Val Val Lys Leu Ser Leu Pro Leu Tyr 
            740                 745                 750         


Leu Ile Tyr Glu 
        755     


<210>  3216
<211>  694
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3216

Xaa Pro Lys Ala Ala Tyr Asp Tyr Cys Glu His Tyr Ser Pro Asp Cys 
1               5                   10                  15      


Asp Ser Ser Ala Pro Lys Ala Ala Gln Ala Gln Glu Pro Gln Ile Asp 
            20                  25                  30          


Glu Tyr Ala Pro Glu Asp Ile Ile Glu Tyr Asp Tyr Glu Tyr Gly Glu 
        35                  40                  45              


Ala Glu Tyr Lys Glu Ala Glu Ser Val Thr Glu Gly Pro Thr Val Thr 
    50                  55                  60                  


Glu Glu Thr Ile Ala Gln Thr Glu Ala Asn Ile Val Asp Asp Phe Gln 
65                  70                  75                  80  


Glu Tyr Asn Tyr Gly Thr Met Glu Ser Tyr Gln Thr Glu Ala Pro Arg 
                85                  90                  95      


His Val Ser Gly Thr Asn Glu Pro Asn Pro Val Glu Glu Ile Phe Thr 
            100                 105                 110         


Glu Glu Tyr Leu Thr Gly Glu Asp Tyr Asp Ser Gln Arg Lys Asn Ser 
        115                 120                 125             


Glu Asp Thr Leu Tyr Glu Asn Lys Glu Ile Asp Gly Arg Asp Ser Asp 
    130                 135                 140                 


Leu Leu Val Asp Gly Asp Leu Gly Glu Tyr Asp Phe Tyr Glu Tyr Lys 
145                 150                 155                 160 


Glu Tyr Glu Asp Lys Pro Thr Ser Pro Pro Asn Glu Glu Phe Gly Pro 
                165                 170                 175     


Gly Val Pro Ala Glu Thr Asp Ile Thr Glu Thr Ser Ile Asn Gly His 
            180                 185                 190         


Gly Ala Tyr Gly Glu Lys Gly Gln Lys Gly Glu Pro Ala Val Val Glu 
        195                 200                 205             


Pro Gly Met Leu Val Glu Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly 
    210                 215                 220                 


Ile Met Gly Pro Pro Gly Leu Gln Gly Pro Thr Gly Pro Pro Gly Asp 
225                 230                 235                 240 


Pro Gly Asp Arg Gly Pro Pro Gly Arg Pro Gly Leu Pro Gly Ala Asp 
                245                 250                 255     


Gly Leu Pro Gly Pro Pro Gly Thr Met Leu Met Leu Pro Phe Arg Tyr 
            260                 265                 270         


Gly Gly Asp Gly Ser Lys Gly Pro Thr Ile Ser Ala Gln Glu Ala Gln 
        275                 280                 285             


Ala Gln Ala Ile Leu Gln Gln Ala Arg Ile Ala Leu Arg Gly Pro Pro 
    290                 295                 300                 


Gly Pro Met Gly Leu Thr Gly Arg Pro Gly Pro Val Gly Gly Pro Gly 
305                 310                 315                 320 


Ser Ser Gly Ala Lys Gly Glu Ser Gly Asp Pro Gly Pro Gln Gly Pro 
                325                 330                 335     


Arg Gly Val Gln Gly Pro Pro Gly Pro Thr Gly Lys Pro Gly Lys Arg 
            340                 345                 350         


Gly Arg Pro Gly Ala Asp Gly Gly Arg Gly Met Pro Gly Glu Pro Gly 
        355                 360                 365             


Ala Lys Gly Asp Arg Gly Phe Asp Gly Leu Pro Gly Leu Pro Gly Asp 
    370                 375                 380                 


Lys Gly His Arg Gly Glu Arg Gly Pro Gln Gly Pro Pro Gly Pro Pro 
385                 390                 395                 400 


Gly Asp Asp Gly Met Arg Gly Glu Asp Gly Glu Ile Gly Pro Arg Gly 
                405                 410                 415     


Leu Pro Gly Glu Ala Gly Pro Arg Gly Leu Leu Gly Pro Arg Gly Thr 
            420                 425                 430         


Pro Gly Ala Pro Gly Gln Pro Gly Met Ala Gly Val Asp Gly Pro Pro 
        435                 440                 445             


Gly Pro Lys Gly Asn Met Gly Pro Gln Gly Glu Pro Gly Pro Pro Gly 
    450                 455                 460                 


Gln Gln Gly Asn Pro Gly Pro Gln Gly Leu Pro Gly Pro Gln Gly Pro 
465                 470                 475                 480 


Ile Gly Pro Pro Gly Glu Lys Gly Pro Gln Gly Lys Pro Gly Leu Ala 
                485                 490                 495     


Gly Leu Pro Gly Ala Asp Gly Pro Pro Gly His Pro Gly Lys Glu Gly 
            500                 505                 510         


Gln Ser Gly Glu Lys Gly Ala Leu Gly Pro Pro Gly Pro Gln Gly Pro 
        515                 520                 525             


Ile Gly Tyr Pro Gly Pro Arg Gly Val Lys Gly Ala Asp Gly Val Arg 
    530                 535                 540                 


Gly Leu Lys Gly Ser Lys Gly Glu Lys Gly Glu Asp Gly Phe Pro Gly 
545                 550                 555                 560 


Phe Lys Gly Asp Met Gly Leu Lys Gly Asp Arg Gly Glu Val Gly Gln 
                565                 570                 575     


Ile Gly Pro Arg Gly Glu Asp Gly Pro Glu Gly Pro Lys Gly Arg Ala 
            580                 585                 590         


Gly Pro Thr Gly Asp Pro Gly Pro Ser Gly Gln Ala Gly Glu Lys Gly 
        595                 600                 605             


Lys Leu Gly Val Pro Gly Leu Pro Gly Tyr Pro Gly Arg Gln Gly Pro 
    610                 615                 620                 


Lys Asp Phe Arg Cys His Trp Phe His Trp Ile Pro Trp Val Ser Arg 
625                 630                 635                 640 


Cys Gln Trp Arg Glu Arg Cys Thr Gly Ser Ser Trp Gln Thr Arg Pro 
                645                 650                 655     


Ser Gly Ser Ala Trp Ser Asn Gly Ser Ser Arg Phe Lys Arg Cys Lys 
            660                 665                 670         


Arg Ser His Trp Glu Thr Trp Ala Lys Gly His Phe Arg Trp Arg Trp 
        675                 680                 685             


Pro Ser Trp Pro Ser Arg 
    690                 


<210>  3217
<211>  200
<212>  PRT
<213>  Homo Sapiens

<400>  3217

Tyr Arg Val Ser Lys Gln Ala Gln Leu Ser Ala Pro Thr Lys Gln Leu 
1               5                   10                  15      


Phe Pro Gly Gly Thr Phe Pro Glu Asp Phe Ser Ile Leu Phe Thr Val 
            20                  25                  30          


Lys Pro Lys Lys Gly Ile Gln Ser Phe Leu Leu Ser Ile Tyr Asn Glu 
        35                  40                  45              


His Gly Ile Gln Gln Ile Gly Val Glu Val Gly Arg Ser Pro Val Phe 
    50                  55                  60                  


Leu Phe Glu Asp His Thr Gly Lys Pro Ala Pro Glu Asp Tyr Pro Leu 
65                  70                  75                  80  


Phe Arg Thr Val Asn Ile Ala Asp Gly Lys Trp His Arg Val Ala Ile 
                85                  90                  95      


Ser Val Glu Lys Lys Thr Val Thr Met Ile Val Asp Cys Lys Lys Lys 
            100                 105                 110         


Thr Thr Lys Pro Leu Asp Arg Ser Glu Arg Ala Ile Val Asp Thr Asn 
        115                 120                 125             


Gly Ile Thr Val Phe Gly Thr Arg Ile Leu Asp Glu Glu Val Phe Glu 
    130                 135                 140                 


Gly Asp Ile Gln Gln Phe Leu Ile Thr Gly Asp Pro Lys Ala Ala Tyr 
145                 150                 155                 160 


Asp Tyr Cys Glu His Tyr Ser Pro Asp Cys Asp Ser Ser Ala Pro Lys 
                165                 170                 175     


Ala Ala Gln Ala Gln Glu Pro Gln Ile Asp Glu Val Arg Ser Thr Arg 
            180                 185                 190         


Pro Glu Lys Val Phe Val Phe Gln 
        195                 200 


<210>  3218
<211>  1736
<212>  PRT
<213>  Homo Sapiens

<400>  3218

Met Glu Arg Cys Ser Arg Cys His Arg Leu Leu Leu Leu Leu Pro Leu 
1               5                   10                  15      


Val Leu Gly Leu Ser Ala Ala Pro Gly Trp Ala Gly Ala Pro Pro Val 
            20                  25                  30          


Asp Val Leu Arg Ala Leu Arg Phe Pro Ser Leu Pro Asp Gly Val Arg 
        35                  40                  45              


Arg Ala Lys Gly Ile Cys Pro Ala Asp Val Ala Tyr Arg Val Ala Arg 
    50                  55                  60                  


Pro Ala Gln Leu Ser Ala Pro Thr Arg Gln Leu Phe Pro Gly Gly Phe 
65                  70                  75                  80  


Pro Lys Asp Phe Ser Leu Leu Thr Val Val Arg Thr Arg Pro Gly Leu 
                85                  90                  95      


Gln Ala Pro Leu Leu Thr Leu Tyr Ser Ala Gln Gly Val Arg Gln Leu 
            100                 105                 110         


Gly Leu Glu Leu Gly Arg Pro Val Arg Phe Leu Tyr Glu Asp Gln Thr 
        115                 120                 125             


Gly Arg Pro Gln Pro Pro Ser Gln Pro Val Phe Arg Gly Leu Ser Leu 
    130                 135                 140                 


Ala Asp Gly Lys Trp His Arg Val Ala Val Ala Val Lys Gly Gln Ser 
145                 150                 155                 160 


Val Thr Leu Ile Val Asp Cys Lys Lys Arg Val Thr Arg Pro Leu Pro 
                165                 170                 175     


Arg Ser Ala Arg Pro Val Leu Asp Thr His Gly Val Ile Ile Phe Gly 
            180                 185                 190         


Ala Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Val Gln Glu Leu 
        195                 200                 205             


Ala Ile Val Pro Gly Val Gln Ala Ala Tyr Glu Ser Cys Glu Gln Lys 
    210                 215                 220                 


Glu Leu Glu Cys Glu Gly Gly Gln Arg Glu Arg Pro Gln Asn Gln Gln 
225                 230                 235                 240 


Pro His Arg Ala Gln Arg Ser Pro Gln Gln Gln Pro Ser Arg Leu His 
                245                 250                 255     


Arg Pro Gln Asn Gln Glu Pro Gln Ser Gln Pro Thr Glu Ser Leu Tyr 
            260                 265                 270         


Tyr Asp Tyr Glu Pro Pro Tyr Tyr Asp Val Met Thr Thr Gly Thr Thr 
        275                 280                 285             


Pro Asp Tyr Gln Asp Pro Thr Pro Gly Glu Glu Glu Glu Ile Leu Glu 
    290                 295                 300                 


Ser Ser Leu Leu Pro Pro Leu Glu Glu Glu Gln Thr Asp Leu Gln Val 
305                 310                 315                 320 


Pro Pro Thr Ala Asp Arg Phe Gln Ala Glu Glu Tyr Gly Glu Gly Gly 
                325                 330                 335     


Thr Asp Pro Pro Glu Gly Pro Tyr Asp Tyr Thr Tyr Gly Tyr Gly Asp 
            340                 345                 350         


Asp Tyr Arg Glu Glu Thr Glu Leu Gly Pro Ala Leu Ser Ala Glu Thr 
        355                 360                 365             


Ala His Ser Gly Ala Ala Ala His Gly Pro Arg Gly Leu Lys Gly Glu 
    370                 375                 380                 


Lys Gly Glu Pro Ala Val Leu Glu Pro Gly Met Leu Val Glu Gly Pro 
385                 390                 395                 400 


Pro Gly Pro Glu Gly Pro Ala Gly Leu Ile Gly Pro Pro Gly Ile Gln 
                405                 410                 415     


Gly Asn Pro Gly Pro Val Gly Asp Pro Gly Glu Arg Gly Pro Pro Gly 
            420                 425                 430         


Arg Ala Gly Leu Pro Gly Ser Asp Gly Ala Pro Gly Pro Pro Gly Thr 
        435                 440                 445             


Ser Leu Met Leu Pro Phe Arg Phe Gly Ser Gly Gly Gly Asp Lys Gly 
    450                 455                 460                 


Pro Val Val Ala Ala Gln Glu Ala Gln Ala Gln Ala Ile Leu Gln Gln 
465                 470                 475                 480 


Ala Arg Leu Ala Leu Arg Gly Pro Pro Gly Pro Met Gly Tyr Thr Gly 
                485                 490                 495     


Arg Pro Gly Pro Leu Gly Gln Pro Gly Ser Pro Gly Leu Lys Gly Glu 
            500                 505                 510         


Ser Gly Asp Leu Gly Pro Gln Gly Pro Arg Gly Pro Gln Gly Leu Thr 
        515                 520                 525             


Gly Pro Pro Gly Lys Ala Gly Arg Arg Gly Arg Ala Gly Ala Asp Gly 
    530                 535                 540                 


Ala Arg Gly Met Pro Gly Asp Pro Gly Val Lys Gly Asp Arg Gly Phe 
545                 550                 555                 560 


Asp Gly Leu Pro Gly Leu Pro Gly Glu Lys Gly His Arg Gly Asp Thr 
                565                 570                 575     


Gly Ala Gln Gly Leu Pro Gly Pro Pro Gly Glu Asp Gly Glu Arg Gly 
            580                 585                 590         


Asp Asp Gly Glu Ile Gly Pro Arg Gly Leu Pro Gly Glu Ser Gly Pro 
        595                 600                 605             


Arg Gly Leu Leu Gly Pro Lys Gly Pro Pro Gly Ile Pro Gly Pro Pro 
    610                 615                 620                 


Gly Val Arg Gly Met Asp Gly Pro Gln Gly Pro Lys Gly Ser Leu Gly 
625                 630                 635                 640 


Pro Gln Gly Glu Pro Gly Pro Pro Gly Gln Gln Gly Thr Pro Gly Thr 
                645                 650                 655     


Gln Gly Leu Pro Gly Pro Gln Gly Ala Ile Gly Pro His Gly Glu Lys 
            660                 665                 670         


Gly Pro Gln Gly Lys Pro Gly Leu Pro Gly Met Pro Gly Ser Asp Gly 
        675                 680                 685             


Pro Pro Gly His Pro Gly Lys Glu Gly Pro Pro Gly Thr Lys Gly Asn 
    690                 695                 700                 


Gln Gly Pro Ser Gly Pro Gln Gly Pro Leu Gly Tyr Pro Gly Pro Arg 
705                 710                 715                 720 


Gly Val Lys Gly Val Asp Gly Ile Arg Gly Leu Lys Gly His Lys Gly 
                725                 730                 735     


Glu Lys Gly Glu Asp Gly Phe Pro Gly Phe Lys Gly Asp Ile Gly Val 
            740                 745                 750         


Lys Gly Asp Arg Gly Glu Val Gly Val Pro Gly Ser Arg Gly Glu Asp 
        755                 760                 765             


Gly Pro Glu Gly Pro Lys Gly Arg Thr Gly Pro Thr Gly Asp Pro Gly 
    770                 775                 780                 


Pro Pro Gly Leu Met Gly Glu Lys Gly Lys Leu Gly Val Pro Gly Leu 
785                 790                 795                 800 


Pro Gly Tyr Pro Gly Arg Gln Gly Pro Lys Gly Ser Leu Gly Phe Pro 
                805                 810                 815     


Gly Phe Pro Gly Ala Ser Gly Glu Lys Gly Ala Arg Gly Leu Ser Gly 
            820                 825                 830         


Lys Ser Gly Pro Arg Gly Glu Arg Gly Pro Thr Gly Pro Arg Gly Gln 
        835                 840                 845             


Arg Gly Pro Arg Gly Ala Thr Gly Lys Ser Gly Ala Lys Gly Thr Ser 
    850                 855                 860                 


Gly Gly Asp Gly Pro His Gly Pro Pro Gly Glu Arg Gly Leu Pro Gly 
865                 870                 875                 880 


Pro Gln Gly Pro Asn Gly Phe Pro Gly Pro Lys Gly Pro Pro Gly Pro 
                885                 890                 895     


Pro Gly Lys Asp Gly Leu Pro Gly His Pro Gly Gln Arg Gly Glu Val 
            900                 905                 910         


Gly Phe Gln Gly Lys Thr Gly Pro Pro Gly Pro Pro Gly Val Val Gly 
        915                 920                 925             


Pro Gln Gly Ala Ala Gly Glu Thr Gly Pro Met Gly Glu Arg Gly His 
    930                 935                 940                 


Pro Gly Pro Pro Gly Pro Pro Gly Glu Gln Gly Leu Pro Gly Thr Ala 
945                 950                 955                 960 


Gly Lys Glu Gly Thr Lys Gly Asp Pro Gly Pro Pro Gly Ala Pro Gly 
                965                 970                 975     


Lys Asp Gly Pro Ala Gly Leu Arg Gly Phe Pro Gly Glu Arg Gly Leu 
            980                 985                 990         


Pro Gly Thr Ala Gly Gly Pro Gly  Leu Lys Gly Asn Glu  Gly Pro Ser 
        995                 1000                 1005             


Gly Pro  Pro Gly Pro Ala Gly  Ser Pro Gly Glu Arg  Gly Ala Ala 
    1010                 1015                 1020             


Gly Ser  Gly Gly Pro Ile Gly  Pro Pro Gly Arg Pro  Gly Pro Gln 
    1025                 1030                 1035             


Gly Pro  Pro Gly Ala Ala Gly  Glu Lys Gly Val Pro  Gly Glu Lys 
    1040                 1045                 1050             


Gly Pro  Ile Gly Pro Thr Gly  Arg Asp Gly Val Gln  Gly Pro Val 
    1055                 1060                 1065             


Gly Leu  Pro Gly Pro Ala Gly  Pro Pro Gly Val Ala  Gly Glu Asp 
    1070                 1075                 1080             


Gly Asp  Lys Gly Glu Val Gly  Asp Pro Gly Gln Lys  Gly Thr Lys 
    1085                 1090                 1095             


Gly Asn  Lys Gly Glu His Gly  Pro Pro Gly Pro Pro  Gly Pro Ile 
    1100                 1105                 1110             


Gly Pro  Val Gly Gln Pro Gly  Ala Ala Gly Ala Asp  Gly Glu Pro 
    1115                 1120                 1125             


Gly Ala  Arg Gly Pro Gln Gly  His Phe Gly Ala Lys  Gly Asp Glu 
    1130                 1135                 1140             


Gly Thr  Arg Gly Phe Asn Gly  Pro Pro Gly Pro Ile  Gly Leu Gln 
    1145                 1150                 1155             


Gly Leu  Pro Gly Pro Ser Gly  Glu Lys Gly Glu Thr  Gly Asp Val 
    1160                 1165                 1170             


Gly Pro  Met Gly Pro Pro Gly  Pro Pro Gly Pro Arg  Gly Pro Ala 
    1175                 1180                 1185             


Gly Pro  Asn Gly Ala Asp Gly  Pro Gln Gly Pro Pro  Gly Gly Val 
    1190                 1195                 1200             


Gly Asn  Leu Gly Pro Pro Gly  Glu Lys Gly Glu Pro  Gly Glu Ser 
    1205                 1210                 1215             


Gly Ser  Pro Gly Ile Gln Gly  Glu Pro Gly Val Lys  Gly Pro Arg 
    1220                 1225                 1230             


Gly Glu  Arg Gly Glu Lys Gly  Glu Ser Gly Gln Pro  Gly Glu Pro 
    1235                 1240                 1245             


Gly Pro  Pro Gly Pro Lys Gly  Pro Thr Gly Asp Asp  Gly Pro Lys 
    1250                 1255                 1260             


Gly Asn  Pro Gly Pro Val Gly  Phe Pro Gly Asp Pro  Gly Pro Pro 
    1265                 1270                 1275             


Gly Glu  Gly Gly Pro Arg Gly  Gln Asp Gly Ala Lys  Gly Asp Arg 
    1280                 1285                 1290             


Gly Glu  Asp Gly Glu Pro Gly  Gln Pro Gly Ser Pro  Gly Pro Thr 
    1295                 1300                 1305             


Gly Glu  Asn Gly Pro Pro Gly  Pro Leu Gly Lys Arg  Gly Pro Ala 
    1310                 1315                 1320             


Gly Ser  Pro Gly Ser Glu Gly  Arg Gln Gly Gly Lys  Gly Ala Lys 
    1325                 1330                 1335             


Gly Asp  Pro Gly Ala Ile Gly  Ala Pro Gly Lys Thr  Gly Pro Val 
    1340                 1345                 1350             


Gly Pro  Ala Gly Pro Ala Gly  Lys Pro Gly Pro Asp  Gly Leu Arg 
    1355                 1360                 1365             


Gly Leu  Pro Gly Ser Val Gly  Gln Gln Gly Arg Pro  Gly Ala Thr 
    1370                 1375                 1380             


Gly Gln  Ala Gly Pro Pro Gly  Pro Val Gly Pro Pro  Gly Leu Pro 
    1385                 1390                 1395             


Gly Leu  Arg Gly Asp Ala Gly  Ala Lys Gly Glu Lys  Gly His Pro 
    1400                 1405                 1410             


Gly Leu  Ile Gly Leu Ile Gly  Pro Pro Gly Glu Gln  Gly Glu Lys 
    1415                 1420                 1425             


Gly Asp  Arg Gly Leu Pro Gly  Pro Gln Gly Ser Pro  Gly Gln Lys 
    1430                 1435                 1440             


Gly Glu  Met Gly Ile Pro Gly  Ala Ser Gly Pro Ile  Gly Pro Gly 
    1445                 1450                 1455             


Gly Pro  Pro Gly Leu Pro Gly  Pro Ala Gly Pro Lys  Gly Ala Lys 
    1460                 1465                 1470             


Gly Ala  Thr Gly Pro Gly Gly  Pro Lys Gly Glu Lys  Gly Val Gln 
    1475                 1480                 1485             


Gly Pro  Pro Gly His Pro Gly  Pro Pro Gly Glu Val  Ile Gln Pro 
    1490                 1495                 1500             


Leu Pro  Ile Gln Met Pro Lys  Lys Thr Arg Arg Ser  Val Asp Gly 
    1505                 1510                 1515             


Ser Arg  Leu Met Gln Glu Asp  Glu Ala Ile Pro Thr  Gly Gly Ala 
    1520                 1525                 1530             


Pro Gly  Ser Pro Gly Gly Leu  Glu Glu Ile Phe Gly  Ser Leu Asp 
    1535                 1540                 1545             


Ser Leu  Arg Glu Glu Ile Glu  Gln Met Arg Arg Pro  Thr Gly Thr 
    1550                 1555                 1560             


Gln Asp  Ser Pro Ala Arg Thr  Cys Gln Asp Leu Lys  Leu Cys His 
    1565                 1570                 1575             


Pro Glu  Leu Pro Asp Gly Glu  Tyr Trp Val Asp Pro  Asn Gln Gly 
    1580                 1585                 1590             


Cys Ala  Arg Asp Ala Phe Arg  Val Phe Cys Asn Phe  Thr Ala Gly 
    1595                 1600                 1605             


Gly Glu  Thr Cys Val Thr Pro  Arg Asp Asp Val Thr  Gln Phe Ser 
    1610                 1615                 1620             


Tyr Val  Asp Ser Glu Gly Ser  Pro Val Gly Val Val  Gln Leu Thr 
    1625                 1630                 1635             


Phe Leu  Arg Leu Leu Ser Val  Ser Ala His Gln Asp  Val Ser Tyr 
    1640                 1645                 1650             


Pro Cys  Ser Gly Ala Ala Arg  Asp Gly Pro Leu Arg  Leu Arg Gly 
    1655                 1660                 1665             


Ala Asn  Glu Asp Glu Leu Ser  Pro Glu Thr Ser Pro  Tyr Val Lys 
    1670                 1675                 1680             


Glu Phe  Arg Asp Gly Cys Gln  Thr Gln Gln Gly Arg  Thr Val Leu 
    1685                 1690                 1695             


Glu Val  Arg Thr Pro Val Leu  Glu Gln Leu Pro Val  Leu Asp Ala 
    1700                 1705                 1710             


Ser Phe  Ser Asp Leu Gly Ala  Pro Pro Arg Arg Gly  Gly Val Leu 
    1715                 1720                 1725             


Leu Gly  Pro Val Cys Phe Met  Gly 
    1730                 1735     


<210>  3219
<211>  1629
<212>  PRT
<213>  Homo Sapiens

<400>  3219

Met Glu Arg Cys Ser Arg Cys His Arg Leu Leu Leu Leu Leu Pro Leu 
1               5                   10                  15      


Val Leu Gly Leu Ser Ala Ala Pro Gly Trp Ala Gly Ala Pro Pro Val 
            20                  25                  30          


Asp Val Leu Arg Ala Leu Arg Phe Pro Ser Leu Pro Asp Gly Val Arg 
        35                  40                  45              


Arg Ala Lys Gly Ile Cys Pro Ala Asp Val Ala Tyr Arg Val Ala Arg 
    50                  55                  60                  


Pro Ala Gln Leu Ser Ala Pro Thr Arg Gln Leu Phe Pro Gly Gly Phe 
65                  70                  75                  80  


Pro Lys Asp Phe Ser Leu Leu Thr Val Val Arg Thr Arg Pro Gly Leu 
                85                  90                  95      


Gln Ala Pro Leu Leu Thr Leu Tyr Ser Ala Gln Gly Val Arg Gln Leu 
            100                 105                 110         


Gly Leu Glu Leu Gly Arg Pro Val Arg Phe Leu Tyr Glu Asp Gln Thr 
        115                 120                 125             


Gly Arg Pro Gln Pro Pro Ser Gln Pro Val Phe Arg Gly Leu Ser Leu 
    130                 135                 140                 


Ala Asp Gly Lys Trp His Arg Val Ala Val Ala Val Lys Gly Gln Ser 
145                 150                 155                 160 


Val Thr Leu Ile Val Asp Cys Lys Lys Arg Val Thr Arg Pro Leu Pro 
                165                 170                 175     


Arg Ser Ala Arg Pro Val Leu Asp Thr His Gly Val Ile Ile Phe Gly 
            180                 185                 190         


Ala Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Val Gln Glu Leu 
        195                 200                 205             


Ala Ile Val Pro Gly Val Gln Ala Ala Tyr Glu Ser Cys Glu Gln Lys 
    210                 215                 220                 


Glu Leu Glu Cys Glu Gly Gly Gln Arg Glu Arg Pro Gln Asn Gln Gln 
225                 230                 235                 240 


Pro His Arg Ala Gln Arg Ser Pro Gln Gln Gln Pro Ser Arg Leu His 
                245                 250                 255     


Arg Pro Gln Asn Gln Glu Pro Gln Ser Gln Ala Ala His Gly Pro Arg 
            260                 265                 270         


Gly Leu Lys Gly Glu Lys Gly Glu Pro Ala Val Leu Glu Pro Gly Met 
        275                 280                 285             


Leu Val Glu Gly Pro Pro Gly Pro Glu Gly Pro Ala Gly Leu Ile Gly 
    290                 295                 300                 


Pro Pro Gly Ile Gln Gly Asn Pro Gly Pro Val Gly Asp Pro Gly Glu 
305                 310                 315                 320 


Arg Gly Pro Pro Gly Arg Ala Gly Leu Pro Gly Ser Asp Gly Ala Pro 
                325                 330                 335     


Gly Pro Pro Gly Thr Ser Leu Met Leu Pro Phe Arg Phe Gly Ser Gly 
            340                 345                 350         


Gly Gly Asp Lys Gly Pro Val Val Ala Ala Gln Glu Ala Gln Ala Gln 
        355                 360                 365             


Ala Ile Leu Gln Gln Ala Arg Leu Ala Leu Arg Gly Pro Pro Gly Pro 
    370                 375                 380                 


Met Gly Tyr Thr Gly Arg Pro Gly Pro Leu Gly Gln Pro Gly Ser Pro 
385                 390                 395                 400 


Gly Leu Lys Gly Glu Ser Gly Asp Leu Gly Pro Gln Gly Pro Arg Gly 
                405                 410                 415     


Pro Gln Gly Leu Thr Gly Pro Pro Gly Lys Ala Gly Arg Arg Gly Arg 
            420                 425                 430         


Ala Gly Ala Asp Gly Ala Arg Gly Met Pro Gly Asp Pro Gly Val Lys 
        435                 440                 445             


Gly Asp Arg Gly Phe Asp Gly Leu Pro Gly Leu Pro Gly Glu Lys Gly 
    450                 455                 460                 


His Arg Gly Asp Thr Gly Ala Gln Gly Leu Pro Gly Pro Pro Gly Glu 
465                 470                 475                 480 


Asp Gly Glu Arg Gly Asp Asp Gly Glu Ile Gly Pro Arg Gly Leu Pro 
                485                 490                 495     


Gly Glu Ser Gly Pro Arg Gly Leu Leu Gly Pro Lys Gly Pro Pro Gly 
            500                 505                 510         


Ile Pro Gly Pro Pro Gly Val Arg Gly Met Asp Gly Pro Gln Gly Pro 
        515                 520                 525             


Lys Gly Ser Leu Gly Pro Gln Gly Glu Pro Gly Pro Pro Gly Gln Gln 
    530                 535                 540                 


Gly Thr Pro Gly Thr Gln Gly Leu Pro Gly Pro Gln Gly Ala Ile Gly 
545                 550                 555                 560 


Pro His Gly Glu Lys Gly Pro Gln Gly Lys Pro Gly Leu Pro Gly Met 
                565                 570                 575     


Pro Gly Ser Asp Gly Pro Pro Gly His Pro Gly Lys Glu Gly Pro Pro 
            580                 585                 590         


Gly Thr Lys Gly Asn Gln Gly Pro Ser Gly Pro Gln Gly Pro Leu Gly 
        595                 600                 605             


Tyr Pro Gly Pro Arg Gly Val Lys Gly Val Asp Gly Ile Arg Gly Leu 
    610                 615                 620                 


Lys Gly His Lys Gly Glu Lys Gly Glu Asp Gly Phe Pro Gly Phe Lys 
625                 630                 635                 640 


Gly Asp Ile Gly Val Lys Gly Asp Arg Gly Glu Val Gly Val Pro Gly 
                645                 650                 655     


Ser Arg Gly Glu Asp Gly Pro Glu Gly Pro Lys Gly Arg Thr Gly Pro 
            660                 665                 670         


Thr Gly Asp Pro Gly Pro Pro Gly Leu Met Gly Glu Lys Gly Lys Leu 
        675                 680                 685             


Gly Val Pro Gly Leu Pro Gly Tyr Pro Gly Arg Gln Gly Pro Lys Gly 
    690                 695                 700                 


Ser Leu Gly Phe Pro Gly Phe Pro Gly Ala Ser Gly Glu Lys Gly Ala 
705                 710                 715                 720 


Arg Gly Leu Ser Gly Lys Ser Gly Pro Arg Gly Glu Arg Gly Pro Thr 
                725                 730                 735     


Gly Pro Arg Gly Gln Arg Gly Pro Arg Gly Ala Thr Gly Lys Ser Gly 
            740                 745                 750         


Ala Lys Gly Thr Ser Gly Gly Asp Gly Pro His Gly Pro Pro Gly Glu 
        755                 760                 765             


Arg Gly Leu Pro Gly Pro Gln Gly Pro Asn Gly Phe Pro Gly Pro Lys 
    770                 775                 780                 


Gly Pro Pro Gly Pro Pro Gly Lys Asp Gly Leu Pro Gly His Pro Gly 
785                 790                 795                 800 


Gln Arg Gly Glu Val Gly Phe Gln Gly Lys Thr Gly Pro Pro Gly Pro 
                805                 810                 815     


Pro Gly Val Val Gly Pro Gln Gly Ala Ala Gly Glu Thr Gly Pro Met 
            820                 825                 830         


Gly Glu Arg Gly His Pro Gly Pro Pro Gly Pro Pro Gly Glu Gln Gly 
        835                 840                 845             


Leu Pro Gly Thr Ala Gly Lys Glu Gly Thr Lys Gly Asp Pro Gly Pro 
    850                 855                 860                 


Pro Gly Ala Pro Gly Lys Asp Gly Pro Ala Gly Leu Arg Gly Phe Pro 
865                 870                 875                 880 


Gly Glu Arg Gly Leu Pro Gly Thr Ala Gly Gly Pro Gly Leu Lys Gly 
                885                 890                 895     


Asn Glu Gly Pro Ser Gly Pro Pro Gly Pro Ala Gly Ser Pro Gly Glu 
            900                 905                 910         


Arg Gly Ala Ala Gly Ser Gly Gly Pro Ile Gly Pro Pro Gly Arg Pro 
        915                 920                 925             


Gly Pro Gln Gly Pro Pro Gly Ala Ala Gly Glu Lys Gly Val Pro Gly 
    930                 935                 940                 


Glu Lys Gly Pro Ile Gly Pro Thr Gly Arg Asp Gly Val Gln Gly Pro 
945                 950                 955                 960 


Val Gly Leu Pro Gly Pro Ala Gly Pro Pro Gly Val Ala Gly Glu Asp 
                965                 970                 975     


Gly Asp Lys Gly Glu Val Gly Asp Pro Gly Gln Lys Gly Thr Lys Gly 
            980                 985                 990         


Asn Lys Gly Glu His Gly Pro Pro  Gly Pro Pro Gly Pro  Ile Gly Pro 
        995                 1000                 1005             


Val Gly  Gln Pro Gly Ala Ala  Gly Ala Asp Gly Glu  Pro Gly Ala 
    1010                 1015                 1020             


Arg Gly  Pro Gln Gly His Phe  Gly Ala Lys Gly Asp  Glu Gly Thr 
    1025                 1030                 1035             


Arg Gly  Phe Asn Gly Pro Pro  Gly Pro Ile Gly Leu  Gln Gly Leu 
    1040                 1045                 1050             


Pro Gly  Pro Ser Gly Glu Lys  Gly Glu Thr Gly Asp  Val Gly Pro 
    1055                 1060                 1065             


Met Gly  Pro Pro Gly Pro Pro  Gly Pro Arg Gly Pro  Ala Gly Pro 
    1070                 1075                 1080             


Asn Gly  Ala Asp Gly Pro Gln  Gly Pro Pro Gly Gly  Val Gly Asn 
    1085                 1090                 1095             


Leu Gly  Pro Pro Gly Glu Lys  Gly Glu Pro Gly Glu  Ser Gly Ser 
    1100                 1105                 1110             


Pro Gly  Ile Gln Gly Glu Pro  Gly Val Lys Gly Pro  Arg Gly Glu 
    1115                 1120                 1125             


Arg Gly  Glu Lys Gly Glu Ser  Gly Gln Pro Gly Glu  Pro Gly Pro 
    1130                 1135                 1140             


Pro Gly  Pro Lys Gly Pro Thr  Gly Asp Asp Gly Pro  Lys Gly Asn 
    1145                 1150                 1155             


Pro Gly  Pro Val Gly Phe Pro  Gly Asp Pro Gly Pro  Pro Gly Glu 
    1160                 1165                 1170             


Gly Gly  Pro Arg Gly Gln Asp  Gly Ala Lys Gly Asp  Arg Gly Glu 
    1175                 1180                 1185             


Asp Gly  Glu Pro Gly Gln Pro  Gly Ser Pro Gly Pro  Thr Gly Glu 
    1190                 1195                 1200             


Asn Gly  Pro Pro Gly Pro Leu  Gly Lys Arg Gly Pro  Ala Gly Ser 
    1205                 1210                 1215             


Pro Gly  Ser Glu Gly Arg Gln  Gly Gly Lys Gly Ala  Lys Gly Asp 
    1220                 1225                 1230             


Pro Gly  Ala Ile Gly Ala Pro  Gly Lys Thr Gly Pro  Val Gly Pro 
    1235                 1240                 1245             


Ala Gly  Pro Ala Gly Lys Pro  Gly Pro Asp Gly Leu  Arg Gly Leu 
    1250                 1255                 1260             


Pro Gly  Ser Val Gly Gln Gln  Gly Arg Pro Gly Ala  Thr Gly Gln 
    1265                 1270                 1275             


Ala Gly  Pro Pro Gly Pro Val  Gly Pro Pro Gly Leu  Pro Gly Leu 
    1280                 1285                 1290             


Arg Gly  Asp Ala Gly Ala Lys  Gly Glu Lys Gly His  Pro Gly Leu 
    1295                 1300                 1305             


Ile Gly  Leu Ile Gly Pro Pro  Gly Glu Gln Gly Glu  Lys Gly Asp 
    1310                 1315                 1320             


Arg Gly  Leu Pro Gly Pro Gln  Gly Ser Pro Gly Gln  Lys Gly Glu 
    1325                 1330                 1335             


Met Gly  Ile Pro Gly Ala Ser  Gly Pro Ile Gly Pro  Gly Gly Pro 
    1340                 1345                 1350             


Pro Gly  Leu Pro Gly Pro Ala  Gly Pro Lys Gly Ala  Lys Gly Ala 
    1355                 1360                 1365             


Thr Gly  Pro Gly Gly Pro Lys  Gly Glu Lys Gly Val  Gln Gly Pro 
    1370                 1375                 1380             


Pro Gly  His Pro Gly Pro Pro  Gly Glu Val Ile Gln  Pro Leu Pro 
    1385                 1390                 1395             


Ile Gln  Met Pro Lys Lys Thr  Arg Arg Ser Val Asp  Gly Ser Arg 
    1400                 1405                 1410             


Leu Met  Gln Glu Asp Glu Ala  Ile Pro Thr Gly Gly  Ala Pro Gly 
    1415                 1420                 1425             


Ser Pro  Gly Gly Leu Glu Glu  Ile Phe Gly Ser Leu  Asp Ser Leu 
    1430                 1435                 1440             


Arg Glu  Glu Ile Glu Gln Met  Arg Arg Pro Thr Gly  Thr Gln Asp 
    1445                 1450                 1455             


Ser Pro  Ala Arg Thr Cys Gln  Asp Leu Lys Leu Cys  His Pro Glu 
    1460                 1465                 1470             


Leu Pro  Asp Gly Glu Tyr Trp  Val Asp Pro Asn Gln  Gly Cys Ala 
    1475                 1480                 1485             


Arg Asp  Ala Phe Arg Val Phe  Cys Asn Phe Thr Ala  Gly Gly Glu 
    1490                 1495                 1500             


Thr Cys  Val Thr Pro Arg Asp  Asp Val Thr Gln Phe  Ser Tyr Val 
    1505                 1510                 1515             


Asp Ser  Glu Gly Ser Pro Val  Gly Val Val Gln Leu  Thr Phe Leu 
    1520                 1525                 1530             


Arg Leu  Leu Ser Val Ser Ala  His Gln Asp Val Ser  Tyr Pro Cys 
    1535                 1540                 1545             


Ser Gly  Ala Ala Arg Asp Gly  Pro Leu Arg Leu Arg  Gly Ala Asn 
    1550                 1555                 1560             


Glu Asp  Glu Leu Ser Pro Glu  Thr Ser Pro Tyr Val  Lys Glu Phe 
    1565                 1570                 1575             


Arg Asp  Gly Cys Gln Thr Gln  Gln Gly Arg Thr Val  Leu Glu Val 
    1580                 1585                 1590             


Arg Thr  Pro Val Leu Glu Gln  Leu Pro Val Leu Asp  Ala Ser Phe 
    1595                 1600                 1605             


Ser Asp  Leu Gly Ala Pro Pro  Arg Arg Gly Gly Val  Leu Leu Gly 
    1610                 1615                 1620             


Pro Val  Cys Phe Met Gly 
    1625                 


<210>  3220
<211>  290
<212>  PRT
<213>  Homo Sapiens

<400>  3220

Met Glu Arg Cys Ser Arg Cys His Arg Leu Leu Leu Leu Leu Pro Leu 
1               5                   10                  15      


Val Leu Gly Leu Ser Ala Ala Pro Gly Trp Ala Gly Ala Pro Pro Val 
            20                  25                  30          


Asp Val Leu Arg Ala Leu Arg Phe Pro Ser Leu Pro Asp Gly Val Arg 
        35                  40                  45              


Arg Ala Lys Gly Ile Cys Pro Ala Asp Val Ala Tyr Arg Val Ala Arg 
    50                  55                  60                  


Pro Ala Gln Leu Ser Ala Pro Thr Arg Gln Leu Phe Pro Gly Gly Phe 
65                  70                  75                  80  


Pro Lys Asp Phe Ser Leu Leu Thr Val Val Arg Thr Arg Pro Gly Leu 
                85                  90                  95      


Gln Ala Pro Leu Leu Thr Leu Tyr Ser Ala Gln Gly Val Arg Gln Leu 
            100                 105                 110         


Gly Leu Glu Leu Gly Arg Pro Val Arg Phe Leu Tyr Glu Asp Gln Thr 
        115                 120                 125             


Gly Arg Pro Gln Pro Pro Ser Gln Pro Val Phe Arg Gly Leu Ser Leu 
    130                 135                 140                 


Ala Asp Gly Lys Trp His Arg Val Ala Val Ala Val Lys Gly Gln Ser 
145                 150                 155                 160 


Val Thr Leu Ile Val Asp Cys Lys Lys Arg Val Thr Arg Pro Leu Pro 
                165                 170                 175     


Arg Ser Ala Arg Pro Val Leu Asp Thr His Gly Val Ile Ile Phe Gly 
            180                 185                 190         


Ala Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Val Gln Glu Leu 
        195                 200                 205             


Ala Ile Val Pro Gly Val Gln Ala Ala Tyr Glu Ser Cys Glu Gln Lys 
    210                 215                 220                 


Glu Leu Glu Cys Glu Gly Gly Gln Arg Glu Arg Pro Gln Asn Gln Gln 
225                 230                 235                 240 


Pro His Arg Ala Gln Arg Ser Pro Gln Gln Gln Pro Ser Arg Leu His 
                245                 250                 255     


Arg Pro Gln Asn Gln Glu Pro Gln Ser Gln Val Arg Glu Leu Gly Glu 
            260                 265                 270         


Pro Pro Ser Ala Ala His Pro Arg Glu Gly Arg His Pro Gly Ile Ser 
        275                 280                 285             


Pro Pro 
    290 


<210>  3221
<211>  1650
<212>  PRT
<213>  Homo Sapiens

<400>  3221

Met Glu Arg Cys Ser Arg Cys His Arg Leu Leu Leu Leu Leu Pro Leu 
1               5                   10                  15      


Val Leu Gly Leu Ser Ala Ala Pro Gly Trp Ala Gly Ala Pro Pro Val 
            20                  25                  30          


Asp Val Leu Arg Ala Leu Arg Phe Pro Ser Leu Pro Asp Gly Val Arg 
        35                  40                  45              


Arg Ala Lys Gly Ile Cys Pro Ala Asp Val Ala Tyr Arg Val Ala Arg 
    50                  55                  60                  


Pro Ala Gln Leu Ser Ala Pro Thr Arg Gln Leu Phe Pro Gly Gly Phe 
65                  70                  75                  80  


Pro Lys Asp Phe Ser Leu Leu Thr Val Val Arg Thr Arg Pro Gly Leu 
                85                  90                  95      


Gln Ala Pro Leu Leu Thr Leu Tyr Ser Ala Gln Gly Val Arg Gln Leu 
            100                 105                 110         


Gly Leu Glu Leu Gly Arg Pro Val Arg Phe Leu Tyr Glu Asp Gln Thr 
        115                 120                 125             


Gly Arg Pro Gln Pro Pro Ser Gln Pro Val Phe Arg Gly Leu Ser Leu 
    130                 135                 140                 


Ala Asp Gly Lys Trp His Arg Val Ala Val Ala Val Lys Gly Gln Ser 
145                 150                 155                 160 


Val Thr Leu Ile Val Asp Cys Lys Lys Arg Val Thr Arg Pro Leu Pro 
                165                 170                 175     


Arg Ser Ala Arg Pro Val Leu Asp Thr His Gly Val Ile Ile Phe Gly 
            180                 185                 190         


Ala Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Val Gln Glu Leu 
        195                 200                 205             


Ala Ile Val Pro Gly Val Gln Ala Ala Tyr Glu Ser Cys Glu Gln Lys 
    210                 215                 220                 


Glu Leu Glu Cys Glu Gly Gly Gln Arg Glu Arg Pro Gln Asn Gln Gln 
225                 230                 235                 240 


Pro His Arg Ala Gln Arg Ser Pro Gln Gln Gln Pro Ser Arg Leu His 
                245                 250                 255     


Arg Pro Gln Asn Gln Glu Pro Gln Ser Gln Asp Pro Thr Pro Gly Glu 
            260                 265                 270         


Glu Glu Glu Ile Leu Glu Ser Ser Leu Leu Pro Pro Leu Glu Glu Ala 
        275                 280                 285             


Ala His Gly Pro Arg Gly Leu Lys Gly Glu Lys Gly Glu Pro Ala Val 
    290                 295                 300                 


Leu Glu Pro Gly Met Leu Val Glu Gly Pro Pro Gly Pro Glu Gly Pro 
305                 310                 315                 320 


Ala Gly Leu Ile Gly Pro Pro Gly Ile Gln Gly Asn Pro Gly Pro Val 
                325                 330                 335     


Gly Asp Pro Gly Glu Arg Gly Pro Pro Gly Arg Ala Gly Leu Pro Gly 
            340                 345                 350         


Ser Asp Gly Ala Pro Gly Pro Pro Gly Thr Ser Leu Met Leu Pro Phe 
        355                 360                 365             


Arg Phe Gly Ser Gly Gly Gly Asp Lys Gly Pro Val Val Ala Ala Gln 
    370                 375                 380                 


Glu Ala Gln Ala Gln Ala Ile Leu Gln Gln Ala Arg Leu Ala Leu Arg 
385                 390                 395                 400 


Gly Pro Pro Gly Pro Met Gly Tyr Thr Gly Arg Pro Gly Pro Leu Gly 
                405                 410                 415     


Gln Pro Gly Ser Pro Gly Leu Lys Gly Glu Ser Gly Asp Leu Gly Pro 
            420                 425                 430         


Gln Gly Pro Arg Gly Pro Gln Gly Leu Thr Gly Pro Pro Gly Lys Ala 
        435                 440                 445             


Gly Arg Arg Gly Arg Ala Gly Ala Asp Gly Ala Arg Gly Met Pro Gly 
    450                 455                 460                 


Asp Pro Gly Val Lys Gly Asp Arg Gly Phe Asp Gly Leu Pro Gly Leu 
465                 470                 475                 480 


Pro Gly Glu Lys Gly His Arg Gly Asp Thr Gly Ala Gln Gly Leu Pro 
                485                 490                 495     


Gly Pro Pro Gly Glu Asp Gly Glu Arg Gly Asp Asp Gly Glu Ile Gly 
            500                 505                 510         


Pro Arg Gly Leu Pro Gly Glu Ser Gly Pro Arg Gly Leu Leu Gly Pro 
        515                 520                 525             


Lys Gly Pro Pro Gly Ile Pro Gly Pro Pro Gly Val Arg Gly Met Asp 
    530                 535                 540                 


Gly Pro Gln Gly Pro Lys Gly Ser Leu Gly Pro Gln Gly Glu Pro Gly 
545                 550                 555                 560 


Pro Pro Gly Gln Gln Gly Thr Pro Gly Thr Gln Gly Leu Pro Gly Pro 
                565                 570                 575     


Gln Gly Ala Ile Gly Pro His Gly Glu Lys Gly Pro Gln Gly Lys Pro 
            580                 585                 590         


Gly Leu Pro Gly Met Pro Gly Ser Asp Gly Pro Pro Gly His Pro Gly 
        595                 600                 605             


Lys Glu Gly Pro Pro Gly Thr Lys Gly Asn Gln Gly Pro Ser Gly Pro 
    610                 615                 620                 


Gln Gly Pro Leu Gly Tyr Pro Gly Pro Arg Gly Val Lys Gly Val Asp 
625                 630                 635                 640 


Gly Ile Arg Gly Leu Lys Gly His Lys Gly Glu Lys Gly Glu Asp Gly 
                645                 650                 655     


Phe Pro Gly Phe Lys Gly Asp Ile Gly Val Lys Gly Asp Arg Gly Glu 
            660                 665                 670         


Val Gly Val Pro Gly Ser Arg Gly Glu Asp Gly Pro Glu Gly Pro Lys 
        675                 680                 685             


Gly Arg Thr Gly Pro Thr Gly Asp Pro Gly Pro Pro Gly Leu Met Gly 
    690                 695                 700                 


Glu Lys Gly Lys Leu Gly Val Pro Gly Leu Pro Gly Tyr Pro Gly Arg 
705                 710                 715                 720 


Gln Gly Pro Lys Gly Ser Leu Gly Phe Pro Gly Phe Pro Gly Ala Ser 
                725                 730                 735     


Gly Glu Lys Gly Ala Arg Gly Leu Ser Gly Lys Ser Gly Pro Arg Gly 
            740                 745                 750         


Glu Arg Gly Pro Thr Gly Pro Arg Gly Gln Arg Gly Pro Arg Gly Ala 
        755                 760                 765             


Thr Gly Lys Ser Gly Ala Lys Gly Thr Ser Gly Gly Asp Gly Pro His 
    770                 775                 780                 


Gly Pro Pro Gly Glu Arg Gly Leu Pro Gly Pro Gln Gly Pro Asn Gly 
785                 790                 795                 800 


Phe Pro Gly Pro Lys Gly Pro Pro Gly Pro Pro Gly Lys Asp Gly Leu 
                805                 810                 815     


Pro Gly His Pro Gly Gln Arg Gly Glu Val Gly Phe Gln Gly Lys Thr 
            820                 825                 830         


Gly Pro Pro Gly Pro Pro Gly Val Val Gly Pro Gln Gly Ala Ala Gly 
        835                 840                 845             


Glu Thr Gly Pro Met Gly Glu Arg Gly His Pro Gly Pro Pro Gly Pro 
    850                 855                 860                 


Pro Gly Glu Gln Gly Leu Pro Gly Thr Ala Gly Lys Glu Gly Thr Lys 
865                 870                 875                 880 


Gly Asp Pro Gly Pro Pro Gly Ala Pro Gly Lys Asp Gly Pro Ala Gly 
                885                 890                 895     


Leu Arg Gly Phe Pro Gly Glu Arg Gly Leu Pro Gly Thr Ala Gly Gly 
            900                 905                 910         


Pro Gly Leu Lys Gly Asn Glu Gly Pro Ser Gly Pro Pro Gly Pro Ala 
        915                 920                 925             


Gly Ser Pro Gly Glu Arg Gly Ala Ala Gly Ser Gly Gly Pro Ile Gly 
    930                 935                 940                 


Pro Pro Gly Arg Pro Gly Pro Gln Gly Pro Pro Gly Ala Ala Gly Glu 
945                 950                 955                 960 


Lys Gly Val Pro Gly Glu Lys Gly Pro Ile Gly Pro Thr Gly Arg Asp 
                965                 970                 975     


Gly Val Gln Gly Pro Val Gly Leu Pro Gly Pro Ala Gly Pro Pro Gly 
            980                 985                 990         


Val Ala Gly Glu Asp Gly Asp Lys  Gly Glu Val Gly Asp  Pro Gly Gln 
        995                 1000                 1005             


Lys Gly  Thr Lys Gly Asn Lys  Gly Glu His Gly Pro  Pro Gly Pro 
    1010                 1015                 1020             


Pro Gly  Pro Ile Gly Pro Val  Gly Gln Pro Gly Ala  Ala Gly Ala 
    1025                 1030                 1035             


Asp Gly  Glu Pro Gly Ala Arg  Gly Pro Gln Gly His  Phe Gly Ala 
    1040                 1045                 1050             


Lys Gly  Asp Glu Gly Thr Arg  Gly Phe Asn Gly Pro  Pro Gly Pro 
    1055                 1060                 1065             


Ile Gly  Leu Gln Gly Leu Pro  Gly Pro Ser Gly Glu  Lys Gly Glu 
    1070                 1075                 1080             


Thr Gly  Asp Val Gly Pro Met  Gly Pro Pro Gly Pro  Pro Gly Pro 
    1085                 1090                 1095             


Arg Gly  Pro Ala Gly Pro Asn  Gly Ala Asp Gly Pro  Gln Gly Pro 
    1100                 1105                 1110             


Pro Gly  Gly Val Gly Asn Leu  Gly Pro Pro Gly Glu  Lys Gly Glu 
    1115                 1120                 1125             


Pro Gly  Glu Ser Gly Ser Pro  Gly Ile Gln Gly Glu  Pro Gly Val 
    1130                 1135                 1140             


Lys Gly  Pro Arg Gly Glu Arg  Gly Glu Lys Gly Glu  Ser Gly Gln 
    1145                 1150                 1155             


Pro Gly  Glu Pro Gly Pro Pro  Gly Pro Lys Gly Pro  Thr Gly Asp 
    1160                 1165                 1170             


Asp Gly  Pro Lys Gly Asn Pro  Gly Pro Val Gly Phe  Pro Gly Asp 
    1175                 1180                 1185             


Pro Gly  Pro Pro Gly Glu Gly  Gly Pro Arg Gly Gln  Asp Gly Ala 
    1190                 1195                 1200             


Lys Gly  Asp Arg Gly Glu Asp  Gly Glu Pro Gly Gln  Pro Gly Ser 
    1205                 1210                 1215             


Pro Gly  Pro Thr Gly Glu Asn  Gly Pro Pro Gly Pro  Leu Gly Lys 
    1220                 1225                 1230             


Arg Gly  Pro Ala Gly Ser Pro  Gly Ser Glu Gly Arg  Gln Gly Gly 
    1235                 1240                 1245             


Lys Gly  Ala Lys Gly Asp Pro  Gly Ala Ile Gly Ala  Pro Gly Lys 
    1250                 1255                 1260             


Thr Gly  Pro Val Gly Pro Ala  Gly Pro Ala Gly Lys  Pro Gly Pro 
    1265                 1270                 1275             


Asp Gly  Leu Arg Gly Leu Pro  Gly Ser Val Gly Gln  Gln Gly Arg 
    1280                 1285                 1290             


Pro Gly  Ala Thr Gly Gln Ala  Gly Pro Pro Gly Pro  Val Gly Pro 
    1295                 1300                 1305             


Pro Gly  Leu Pro Gly Leu Arg  Gly Asp Ala Gly Ala  Lys Gly Glu 
    1310                 1315                 1320             


Lys Gly  His Pro Gly Leu Ile  Gly Leu Ile Gly Pro  Pro Gly Glu 
    1325                 1330                 1335             


Gln Gly  Glu Lys Gly Asp Arg  Gly Leu Pro Gly Pro  Gln Gly Ser 
    1340                 1345                 1350             


Pro Gly  Gln Lys Gly Glu Met  Gly Ile Pro Gly Ala  Ser Gly Pro 
    1355                 1360                 1365             


Ile Gly  Pro Gly Gly Pro Pro  Gly Leu Pro Gly Pro  Ala Gly Pro 
    1370                 1375                 1380             


Lys Gly  Ala Lys Gly Ala Thr  Gly Pro Gly Gly Pro  Lys Gly Glu 
    1385                 1390                 1395             


Lys Gly  Val Gln Gly Pro Pro  Gly His Pro Gly Pro  Pro Gly Glu 
    1400                 1405                 1410             


Val Ile  Gln Pro Leu Pro Ile  Gln Met Pro Lys Lys  Thr Arg Arg 
    1415                 1420                 1425             


Ser Val  Asp Gly Ser Arg Leu  Met Gln Glu Asp Glu  Ala Ile Pro 
    1430                 1435                 1440             


Thr Gly  Gly Ala Pro Gly Ser  Pro Gly Gly Leu Glu  Glu Ile Phe 
    1445                 1450                 1455             


Gly Ser  Leu Asp Ser Leu Arg  Glu Glu Ile Glu Gln  Met Arg Arg 
    1460                 1465                 1470             


Pro Thr  Gly Thr Gln Asp Ser  Pro Ala Arg Thr Cys  Gln Asp Leu 
    1475                 1480                 1485             


Lys Leu  Cys His Pro Glu Leu  Pro Asp Gly Glu Tyr  Trp Val Asp 
    1490                 1495                 1500             


Pro Asn  Gln Gly Cys Ala Arg  Asp Ala Phe Arg Val  Phe Cys Asn 
    1505                 1510                 1515             


Phe Thr  Ala Gly Gly Glu Thr  Cys Val Thr Pro Arg  Asp Asp Val 
    1520                 1525                 1530             


Thr Gln  Phe Ser Tyr Val Asp  Ser Glu Gly Ser Pro  Val Gly Val 
    1535                 1540                 1545             


Val Gln  Leu Thr Phe Leu Arg  Leu Leu Ser Val Ser  Ala His Gln 
    1550                 1555                 1560             


Asp Val  Ser Tyr Pro Cys Ser  Gly Ala Ala Arg Asp  Gly Pro Leu 
    1565                 1570                 1575             


Arg Leu  Arg Gly Ala Asn Glu  Asp Glu Leu Ser Pro  Glu Thr Ser 
    1580                 1585                 1590             


Pro Tyr  Val Lys Glu Phe Arg  Asp Gly Cys Gln Thr  Gln Gln Gly 
    1595                 1600                 1605             


Arg Thr  Val Leu Glu Val Arg  Thr Pro Val Leu Glu  Gln Leu Pro 
    1610                 1615                 1620             


Val Leu  Asp Ala Ser Phe Ser  Asp Leu Gly Ala Pro  Pro Arg Arg 
    1625                 1630                 1635             


Gly Gly  Val Leu Leu Gly Pro  Val Cys Phe Met Gly  
    1640                 1645                 1650 


<210>  3222
<211>  624
<212>  PRT
<213>  Homo Sapiens

<400>  3222

Met Glu Arg Cys Ser Arg Cys His Arg Leu Leu Leu Leu Leu Pro Leu 
1               5                   10                  15      


Val Leu Gly Leu Ser Ala Ala Pro Gly Trp Ala Gly Ala Pro Pro Val 
            20                  25                  30          


Asp Val Leu Arg Ala Leu Arg Phe Pro Ser Leu Pro Asp Gly Val Arg 
        35                  40                  45              


Arg Ala Lys Gly Ile Cys Pro Ala Asp Val Ala Tyr Arg Val Ala Arg 
    50                  55                  60                  


Pro Ala Gln Leu Ser Ala Pro Thr Arg Gln Leu Phe Pro Gly Gly Phe 
65                  70                  75                  80  


Pro Lys Asp Phe Ser Leu Leu Thr Val Val Arg Thr Arg Pro Gly Leu 
                85                  90                  95      


Gln Ala Pro Leu Leu Thr Leu Tyr Ser Ala Gln Gly Val Arg Gln Leu 
            100                 105                 110         


Gly Leu Glu Leu Gly Arg Pro Val Arg Phe Leu Tyr Glu Asp Gln Thr 
        115                 120                 125             


Gly Arg Pro Gln Pro Pro Ser Gln Pro Val Phe Arg Gly Leu Ser Leu 
    130                 135                 140                 


Ala Asp Gly Lys Trp His Arg Val Ala Val Ala Val Lys Gly Gln Ser 
145                 150                 155                 160 


Val Thr Leu Ile Val Asp Cys Lys Lys Arg Val Thr Arg Pro Leu Pro 
                165                 170                 175     


Arg Ser Ala Arg Pro Val Leu Asp Thr His Gly Val Ile Ile Phe Gly 
            180                 185                 190         


Ala Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Val Gln Glu Leu 
        195                 200                 205             


Ala Ile Val Pro Gly Val Gln Ala Ala Tyr Glu Ser Cys Glu Gln Lys 
    210                 215                 220                 


Glu Leu Glu Cys Glu Gly Gly Gln Arg Glu Arg Pro Gln Asn Gln Gln 
225                 230                 235                 240 


Pro His Arg Ala Gln Arg Ser Pro Gln Gln Gln Pro Ser Arg Leu His 
                245                 250                 255     


Arg Pro Gln Asn Gln Glu Pro Gln Ser Gln Pro Thr Glu Ser Leu Tyr 
            260                 265                 270         


Tyr Asp Tyr Glu Pro Pro Tyr Tyr Asp Val Met Thr Thr Gly Thr Thr 
        275                 280                 285             


Pro Asp Tyr Gln Asp Pro Thr Pro Gly Glu Glu Glu Glu Ile Leu Glu 
    290                 295                 300                 


Ser Ser Leu Leu Pro Pro Leu Glu Glu Glu Gln Thr Asp Leu Gln Val 
305                 310                 315                 320 


Pro Pro Thr Ala Asp Arg Phe Gln Ala Glu Glu Tyr Gly Glu Gly Gly 
                325                 330                 335     


Thr Asp Pro Pro Glu Gly Pro Tyr Asp Tyr Thr Tyr Gly Tyr Gly Asp 
            340                 345                 350         


Asp Tyr Arg Glu Glu Thr Glu Leu Gly Pro Ala Leu Ser Ala Glu Thr 
        355                 360                 365             


Ala His Ser Gly Ala Ala Ala His Gly Pro Arg Gly Leu Lys Gly Glu 
    370                 375                 380                 


Lys Gly Glu Pro Ala Val Leu Glu Pro Gly Met Leu Val Glu Gly Pro 
385                 390                 395                 400 


Pro Gly Pro Glu Gly Pro Ala Gly Leu Ile Gly Pro Pro Gly Ile Gln 
                405                 410                 415     


Gly Asn Pro Gly Pro Val Gly Asp Pro Gly Glu Arg Gly Pro Pro Gly 
            420                 425                 430         


Arg Ala Gly Leu Pro Gly Ser Asp Gly Ala Pro Gly Pro Pro Gly Thr 
        435                 440                 445             


Ser Leu Met Leu Pro Phe Arg Phe Gly Ser Gly Gly Gly Asp Lys Gly 
    450                 455                 460                 


Pro Val Val Ala Ala Gln Glu Ala Gln Ala Gln Ala Ile Leu Gln Gln 
465                 470                 475                 480 


Ala Arg Leu Ala Leu Arg Gly Pro Pro Gly Pro Met Gly Tyr Thr Gly 
                485                 490                 495     


Arg Pro Gly Pro Leu Gly Gln Pro Gly Ser Pro Gly Leu Lys Gly Glu 
            500                 505                 510         


Ser Gly Asp Leu Gly Pro Gln Gly Pro Arg Gly Pro Gln Gly Leu Thr 
        515                 520                 525             


Gly Pro Pro Gly Lys Ala Gly Arg Arg Gly Arg Ala Gly Ala Asp Gly 
    530                 535                 540                 


Ala Arg Gly Met Pro Gly Asp Pro Gly Val Lys Gly Asp Arg Gly Phe 
545                 550                 555                 560 


Asp Gly Leu Pro Gly Leu Pro Gly Glu Lys Gly His Arg Gly Asp Thr 
                565                 570                 575     


Gly Ala Gln Gly Leu Pro Gly Pro Pro Gly Glu Asp Gly Glu Arg Gly 
            580                 585                 590         


Asp Asp Gly Glu Ile Gly Pro Arg Gly Leu Pro Gly Glu Ser Gly Pro 
        595                 600                 605             


Arg Gly Leu Leu Gly Pro Lys Gly Pro Pro Gly Ile Pro Gly Pro Pro 
    610                 615                 620                 


<210>  3223
<211>  1874
<212>  PRT
<213>  Homo Sapiens

<400>  3223

Met Glu Cys Leu Thr Arg Ala Glu Ala Asp Ile Val Leu Leu Val Asp 
1               5                   10                  15      


Gly Ser Trp Ser Ile Gly Arg Ala Asn Phe Arg Thr Val Arg Ser Phe 
            20                  25                  30          


Ile Ser Arg Ile Val Glu Val Phe Asp Ile Gly Pro Lys Arg Val Gln 
        35                  40                  45              


Ile Ala Leu Ala Gln Tyr Ser Gly Asp Pro Arg Thr Glu Trp Gln Leu 
    50                  55                  60                  


Asn Ala His Arg Asp Lys Lys Ser Leu Leu Gln Ala Val Ala Asn Leu 
65                  70                  75                  80  


Pro Tyr Lys Gly Gly Asn Thr Leu Thr Gly Met Ala Leu Asn Phe Ile 
                85                  90                  95      


Arg Gln Gln Asn Phe Arg Thr Gln Ala Gly Met Arg Pro Arg Ala Arg 
            100                 105                 110         


Lys Ile Gly Val Leu Ile Thr Asp Gly Lys Ser Gln Asp Asp Val Glu 
        115                 120                 125             


Ala Pro Ser Lys Lys Leu Lys Asp Glu Gly Val Glu Leu Phe Ala Ile 
    130                 135                 140                 


Gly Ile Lys Asn Ala Asp Glu Val Glu Leu Lys Met Ile Ala Thr Asp 
145                 150                 155                 160 


Pro Asp Asp Thr His Ala Tyr Asn Val Ala Asp Phe Glu Ser Leu Ser 
                165                 170                 175     


Arg Ile Val Asp Asp Leu Thr Ile Asn Leu Cys Asn Ser Val Lys Gly 
            180                 185                 190         


Pro Gly Asp Leu Glu Ala Pro Ser Asn Leu Val Ile Ser Glu Arg Thr 
        195                 200                 205             


His Arg Ser Phe Arg Val Ser Trp Thr Pro Pro Ser Asp Ser Val Asp 
    210                 215                 220                 


Arg Tyr Lys Val Glu Tyr Tyr Pro Val Ser Gly Gly Lys Arg Gln Glu 
225                 230                 235                 240 


Phe Tyr Val Ser Arg Met Glu Thr Ser Thr Val Leu Lys Asp Leu Lys 
                245                 250                 255     


Pro Glu Thr Glu Tyr Val Val Asn Val Tyr Ser Val Val Glu Asp Glu 
            260                 265                 270         


Tyr Ser Glu Pro Leu Lys Gly Thr Glu Lys Thr Leu Pro Val Pro Val 
        275                 280                 285             


Val Ser Leu Asn Ile Tyr Asp Val Gly Pro Thr Thr Met His Val Gln 
    290                 295                 300                 


Trp Gln Pro Val Gly Gly Ala Thr Gly Tyr Ile Leu Ser Tyr Lys Pro 
305                 310                 315                 320 


Val Lys Asp Thr Glu Pro Thr Arg Pro Lys Glu Val Arg Leu Gly Pro 
                325                 330                 335     


Thr Val Asn Asp Met Gln Leu Thr Asp Leu Val Pro Asn Thr Glu Tyr 
            340                 345                 350         


Ala Val Thr Val Gln Ala Val Leu His Asp Leu Thr Ser Glu Pro Val 
        355                 360                 365             


Thr Val Arg Glu Val Thr Leu Pro Leu Pro Arg Pro Gln Asp Leu Lys 
    370                 375                 380                 


Leu Arg Asp Val Thr His Ser Thr Met Asn Val Phe Trp Glu Pro Val 
385                 390                 395                 400 


Pro Gly Lys Val Arg Lys Tyr Ile Val Arg Tyr Lys Thr Pro Glu Glu 
                405                 410                 415     


Asp Val Lys Glu Val Glu Val Asp Arg Ser Glu Thr Ser Thr Ser Leu 
            420                 425                 430         


Lys Asp Leu Phe Ser Gln Thr Leu Tyr Thr Val Ser Val Ser Ala Val 
        435                 440                 445             


His Asp Glu Gly Glu Ser Pro Pro Val Thr Ala Gln Glu Thr Thr Arg 
    450                 455                 460                 


Pro Val Pro Ala Pro Thr Asn Leu Lys Ile Thr Glu Val Thr Ser Glu 
465                 470                 475                 480 


Gly Phe Arg Gly Thr Trp Asp His Gly Ala Ser Asp Val Ser Leu Tyr 
                485                 490                 495     


Arg Ile Thr Trp Ala Pro Phe Gly Ser Ser Asp Lys Met Glu Thr Ile 
            500                 505                 510         


Leu Asn Gly Asp Glu Asn Thr Leu Val Phe Glu Asn Leu Asn Pro Asn 
        515                 520                 525             


Thr Ile Tyr Glu Val Ser Ile Thr Ala Ile Tyr Pro Asp Glu Ser Glu 
    530                 535                 540                 


Ser Asp Asp Leu Ile Gly Ser Glu Arg Thr Leu Pro Ile Leu Thr Thr 
545                 550                 555                 560 


Gln Ala Pro Lys Ser Gly Pro Arg Asn Leu Gln Val Tyr Asn Ala Thr 
                565                 570                 575     


Ser Asn Ser Leu Thr Val Lys Trp Asp Pro Ala Ser Gly Arg Val Gln 
            580                 585                 590         


Lys Tyr Arg Ile Thr Tyr Gln Pro Ser Thr Gly Glu Gly Asn Glu Gln 
        595                 600                 605             


Thr Thr Thr Ile Gly Gly Arg Gln Asn Ser Val Val Leu Gln Lys Leu 
    610                 615                 620                 


Lys Pro Asp Thr Pro Tyr Thr Ile Thr Val Ser Ser Leu Tyr Pro Asp 
625                 630                 635                 640 


Gly Glu Gly Gly Arg Met Thr Gly Arg Gly Lys Thr Lys Pro Leu Asn 
                645                 650                 655     


Thr Val Arg Asn Leu Arg Val Tyr Asp Pro Ser Thr Ser Thr Leu Asn 
            660                 665                 670         


Val Arg Trp Asp His Ala Glu Gly Asn Pro Arg Gln Tyr Lys Leu Phe 
        675                 680                 685             


Tyr Ala Pro Ala Ala Gly Gly Pro Glu Glu Leu Val Pro Ile Pro Gly 
    690                 695                 700                 


Asn Thr Asn Tyr Ala Ile Leu Arg Asn Leu Gln Pro Asp Thr Ser Tyr 
705                 710                 715                 720 


Thr Val Thr Val Val Pro Val Tyr Thr Glu Gly Asp Gly Gly Arg Thr 
                725                 730                 735     


Ser Asp Thr Gly Arg Thr Leu Met Arg Gly Leu Ala Arg Asn Val Gln 
            740                 745                 750         


Val Tyr Asn Pro Thr Pro Asn Ser Leu Asp Val Arg Trp Asp Pro Ala 
        755                 760                 765             


Pro Gly Pro Val Leu Gln Tyr Arg Val Val Tyr Ser Pro Val Asp Gly 
    770                 775                 780                 


Thr Arg Pro Ser Glu Ser Ile Val Val Pro Gly Asn Thr Arg Met Val 
785                 790                 795                 800 


His Leu Glu Arg Leu Ile Pro Asp Thr Leu Tyr Ser Val Asn Leu Val 
                805                 810                 815     


Ala Leu Tyr Ser Asp Gly Glu Gly Asn Pro Ser Pro Ala Gln Gly Arg 
            820                 825                 830         


Thr Leu Pro Arg Ser Gly Pro Arg Asn Leu Arg Val Phe Gly Glu Thr 
        835                 840                 845             


Thr Asn Ser Leu Ser Val Ala Trp Asp His Ala Asp Gly Pro Val Gln 
    850                 855                 860                 


Gln Tyr Arg Ile Ile Tyr Ser Pro Thr Val Gly Asp Pro Ile Asp Glu 
865                 870                 875                 880 


Tyr Thr Thr Val Pro Gly Arg Arg Asn Asn Val Ile Leu Gln Pro Leu 
                885                 890                 895     


Gln Pro Asp Thr Pro Tyr Lys Ile Thr Val Ile Ala Val Tyr Glu Asp 
            900                 905                 910         


Gly Asp Gly Gly His Leu Thr Gly Asn Gly Arg Thr Val Gly Leu Leu 
        915                 920                 925             


Pro Pro Gln Asn Ile His Ile Ser Asp Glu Trp Tyr Thr Arg Phe Arg 
    930                 935                 940                 


Val Ser Trp Asp Pro Ser Pro Ser Pro Val Leu Gly Tyr Lys Ile Val 
945                 950                 955                 960 


Tyr Lys Pro Val Gly Ser Asn Glu Pro Met Glu Ala Phe Val Gly Glu 
                965                 970                 975     


Met Thr Ser Tyr Thr Leu His Asn Leu Asn Pro Ser Thr Thr Tyr Asp 
            980                 985                 990         


Val Asn Val Tyr Ala Gln Tyr Asp  Ser Gly Leu Ser Val  Pro Leu Thr 
        995                 1000                 1005             


Asp Gln  Gly Thr Thr Leu Tyr  Leu Asn Val Thr Asp  Leu Lys Thr 
    1010                 1015                 1020             


Tyr Gln  Ile Gly Trp Asp Thr  Phe Cys Val Lys Trp  Ser Pro His 
    1025                 1030                 1035             


Arg Ala  Ala Thr Ser Tyr Arg  Leu Lys Leu Ser Pro  Ala Asp Gly 
    1040                 1045                 1050             


Thr Arg  Gly Gln Glu Ile Thr  Val Arg Gly Ser Glu  Thr Ser His 
    1055                 1060                 1065             


Cys Phe  Thr Gly Leu Ser Pro  Asp Thr Asp Tyr Gly  Val Thr Val 
    1070                 1075                 1080             


Phe Val  Gln Thr Pro Asn Leu  Glu Gly Pro Gly Val  Ser Val Lys 
    1085                 1090                 1095             


Glu His  Thr Thr Val Lys Pro  Thr Glu Ala Pro Thr  Glu Pro Pro 
    1100                 1105                 1110             


Thr Pro  Pro Pro Pro Pro Thr  Ile Pro Pro Ala Arg  Asp Val Cys 
    1115                 1120                 1125             


Lys Gly  Ala Lys Ala Asp Ile  Val Phe Leu Thr Asp  Ala Ser Trp 
    1130                 1135                 1140             


Ser Ile  Gly Asp Asp Asn Phe  Asn Lys Val Val Lys  Phe Ile Phe 
    1145                 1150                 1155             


Asn Thr  Val Gly Gly Phe Asp  Glu Ile Ser Pro Ala  Gly Ile Gln 
    1160                 1165                 1170             


Val Ser  Phe Val Gln Tyr Ser  Asp Glu Val Lys Ser  Glu Phe Lys 
    1175                 1180                 1185             


Leu Asn  Thr Tyr Asn Asp Lys  Ala Leu Ala Leu Gly  Ala Leu Gln 
    1190                 1195                 1200             


Asn Ile  Arg Tyr Arg Gly Gly  Asn Thr Arg Thr Gly  Lys Ala Leu 
    1205                 1210                 1215             


Thr Phe  Ile Lys Glu Lys Val  Leu Thr Trp Glu Ser  Gly Met Arg 
    1220                 1225                 1230             


Lys Asn  Val Pro Lys Val Leu  Val Val Val Thr Asp  Gly Arg Ser 
    1235                 1240                 1245             


Gln Asp  Glu Val Lys Lys Ala  Ala Leu Val Ile Gln  His Ser Arg 
    1250                 1255                 1260             


Phe Ser  Val Phe Val Val Gly  Val Ala Asp Val Asp  Tyr Asn Glu 
    1265                 1270                 1275             


Leu Ala  Asn Ile Ala Ser Lys  Pro Ser Glu Arg His  Val Phe Ile 
    1280                 1285                 1290             


Val Asp  Asp Phe Glu Ser Phe  Glu Lys Ile Glu Asp  Asn Leu Ile 
    1295                 1300                 1305             


Thr Phe  Val Cys Glu Thr Ala  Thr Ser Ser Cys Pro  Leu Ile Tyr 
    1310                 1315                 1320             


Leu Asp  Gly Tyr Thr Ser Pro  Gly Phe Lys Met Leu  Glu Ala Tyr 
    1325                 1330                 1335             


Asn Leu  Thr Glu Lys Asn Phe  Ala Ser Val Gln Gly  Val Ser Leu 
    1340                 1345                 1350             


Glu Ser  Gly Ser Phe Pro Ser  Tyr Ser Ala Tyr Arg  Ile Gln Lys 
    1355                 1360                 1365             


Asn Ala  Phe Val Asn Gln Pro  Thr Ala Asp Leu His  Pro Asn Gly 
    1370                 1375                 1380             


Leu Pro  Pro Ser Tyr Thr Ile  Ile Leu Leu Phe Arg  Leu Leu Pro 
    1385                 1390                 1395             


Glu Thr  Pro Ser Asp Pro Phe  Ala Ile Trp Gln Ile  Thr Asp Arg 
    1400                 1405                 1410             


Asp Tyr  Lys Pro Gln Val Gly  Val Ile Ala Asp Pro  Ser Ser Lys 
    1415                 1420                 1425             


Thr Leu  Ser Phe Phe Asn Lys  Asp Thr Arg Gly Glu  Val Gln Thr 
    1430                 1435                 1440             


Val Thr  Phe Asp Thr Glu Glu  Val Lys Thr Leu Phe  Tyr Gly Ser 
    1445                 1450                 1455             


Phe His  Lys Val His Ile Val  Val Thr Ser Lys Ser  Val Lys Ile 
    1460                 1465                 1470             


Tyr Ile  Asp Cys Tyr Glu Ile  Ile Glu Lys Asp Ile  Lys Glu Ala 
    1475                 1480                 1485             


Gly Asn  Ile Thr Thr Asp Gly  Tyr Glu Ile Leu Gly  Lys Leu Leu 
    1490                 1495                 1500             


Lys Gly  Glu Arg Lys Ser Ala  Ala Phe Gln Ile Gln  Ser Phe Asp 
    1505                 1510                 1515             


Ile Val  Cys Ser Pro Val Trp  Thr Ser Arg Asp Arg  Cys Cys Asp 
    1520                 1525                 1530             


Ile Pro  Ser Arg Arg Asp Glu  Gly Lys Cys Pro Ala  Phe Pro Asn 
    1535                 1540                 1545             


Ser Cys  Thr Cys Thr Gln Asp  Ser Val Gly Pro Pro  Gly Pro Pro 
    1550                 1555                 1560             


Gly Pro  Ala Gly Gly Pro Gly  Ala Lys Gly Pro Arg  Gly Glu Arg 
    1565                 1570                 1575             


Gly Ile  Ser Gly Ala Ile Gly  Pro Pro Gly Pro Arg  Gly Asp Ile 
    1580                 1585                 1590             


Gly Pro  Pro Gly Pro Gln Gly  Pro Pro Gly Pro Gln  Gly Pro Asn 
    1595                 1600                 1605             


Gly Leu  Ser Ile Pro Gly Glu  Gln Gly Arg Gln Gly  Met Lys Gly 
    1610                 1615                 1620             


Asp Ala  Gly Glu Pro Gly Leu  Pro Gly Arg Thr Gly  Thr Pro Gly 
    1625                 1630                 1635             


Leu Pro  Gly Pro Pro Gly Pro  Met Gly Pro Pro Gly  Asp Arg Gly 
    1640                 1645                 1650             


Phe Thr  Gly Lys Asp Gly Ala  Met Gly Pro Arg Gly  Pro Pro Gly 
    1655                 1660                 1665             


Pro Pro  Gly Ser Pro Gly Ser  Pro Gly Val Thr Gly  Pro Ser Gly 
    1670                 1675                 1680             


Lys Pro  Gly Lys Pro Gly Asp  His Gly Arg Pro Gly  Pro Ser Gly 
    1685                 1690                 1695             


Leu Lys  Gly Glu Lys Gly Asp  Arg Gly Asp Ile Ala  Ser Gln Asn 
    1700                 1705                 1710             


Met Met  Arg Ala Val Ala Arg  Gln Val Cys Glu Gln  Leu Ile Ser 
    1715                 1720                 1725             


Gly Gln  Met Asn Arg Phe Asn  Gln Met Leu Asn Gln  Ile Pro Asn 
    1730                 1735                 1740             


Asp Tyr  Gln Ser Ser Arg Asn  Gln Pro Gly Pro Pro  Gly Pro Pro 
    1745                 1750                 1755             


Gly Pro  Pro Gly Ser Ala Gly  Ala Arg Gly Glu Pro  Gly Pro Gly 
    1760                 1765                 1770             


Gly Arg  Pro Gly Phe Pro Gly  Thr Pro Gly Met Gln  Gly Pro Pro 
    1775                 1780                 1785             


Gly Glu  Arg Gly Leu Pro Gly  Glu Lys Gly Glu Arg  Gly Thr Gly 
    1790                 1795                 1800             


Ser Ser  Gly Pro Arg Gly Leu  Pro Gly Pro Pro Gly  Pro Gln Gly 
    1805                 1810                 1815             


Glu Ser  Arg Thr Gly Pro Pro  Gly Ser Thr Gly Ser  Arg Gly Pro 
    1820                 1825                 1830             


Pro Gly  Pro Pro Gly Arg Pro  Gly Asn Ser Gly Ile  Arg Gly Pro 
    1835                 1840                 1845             


Pro Gly  Pro Pro Gly Tyr Cys  Asp Ser Ser Gln Cys  Ala Ser Ile 
    1850                 1855                 1860             


Pro Tyr  Asn Gly Gln Gly Tyr  Pro Gly Ser Gly 
    1865                 1870                 


<210>  3224
<211>  1899
<212>  PRT
<213>  Homo Sapiens

<400>  3224

Met Arg Ser Arg Leu Pro Pro Ala Leu Ala Ala Leu Gly Ala Ala Leu 
1               5                   10                  15      


Leu Leu Ser Ser Ile Glu Ala Glu Gly Met Glu Cys Leu Thr Arg Ala 
            20                  25                  30          


Glu Ala Asp Ile Val Leu Leu Val Asp Gly Ser Trp Ser Ile Gly Arg 
        35                  40                  45              


Ala Asn Phe Arg Thr Val Arg Ser Phe Ile Ser Arg Ile Val Glu Val 
    50                  55                  60                  


Phe Asp Ile Gly Pro Lys Arg Val Gln Ile Ala Leu Ala Gln Tyr Ser 
65                  70                  75                  80  


Gly Asp Pro Arg Thr Glu Trp Gln Leu Asn Ala His Arg Asp Lys Lys 
                85                  90                  95      


Ser Leu Leu Gln Ala Val Ala Asn Leu Pro Tyr Lys Gly Gly Asn Thr 
            100                 105                 110         


Leu Thr Gly Met Ala Leu Asn Phe Ile Arg Gln Gln Asn Phe Arg Thr 
        115                 120                 125             


Gln Ala Gly Met Arg Pro Arg Ala Arg Lys Ile Gly Val Leu Ile Thr 
    130                 135                 140                 


Asp Gly Lys Ser Gln Asp Asp Val Glu Ala Pro Ser Lys Lys Leu Lys 
145                 150                 155                 160 


Asp Glu Gly Val Glu Leu Phe Ala Ile Gly Ile Lys Asn Ala Asp Glu 
                165                 170                 175     


Val Glu Leu Lys Met Ile Ala Thr Asp Pro Asp Asp Thr His Ala Tyr 
            180                 185                 190         


Asn Val Ala Asp Phe Glu Ser Leu Ser Arg Ile Val Asp Asp Leu Thr 
        195                 200                 205             


Ile Asn Leu Cys Asn Ser Val Lys Gly Pro Gly Asp Leu Glu Ala Pro 
    210                 215                 220                 


Ser Asn Leu Val Ile Ser Glu Arg Thr His Arg Ser Phe Arg Val Ser 
225                 230                 235                 240 


Trp Thr Pro Pro Ser Asp Ser Val Asp Arg Tyr Lys Val Glu Tyr Tyr 
                245                 250                 255     


Pro Val Ser Gly Gly Lys Arg Gln Glu Phe Tyr Val Ser Arg Met Glu 
            260                 265                 270         


Thr Ser Thr Val Leu Lys Asp Leu Lys Pro Glu Thr Glu Tyr Val Val 
        275                 280                 285             


Asn Val Tyr Ser Val Val Glu Asp Glu Tyr Ser Glu Pro Leu Lys Gly 
    290                 295                 300                 


Thr Glu Lys Thr Leu Pro Val Pro Val Val Ser Leu Asn Ile Tyr Asp 
305                 310                 315                 320 


Val Gly Pro Thr Thr Met His Val Gln Trp Gln Pro Val Gly Gly Ala 
                325                 330                 335     


Thr Gly Tyr Ile Leu Ser Tyr Lys Pro Val Lys Asp Thr Glu Pro Thr 
            340                 345                 350         


Arg Pro Lys Glu Val Arg Leu Gly Pro Thr Val Asn Asp Met Gln Leu 
        355                 360                 365             


Thr Asp Leu Val Pro Asn Thr Glu Tyr Ala Val Thr Val Gln Ala Val 
    370                 375                 380                 


Leu His Asp Leu Thr Ser Glu Pro Val Thr Val Arg Glu Val Thr Leu 
385                 390                 395                 400 


Pro Leu Pro Arg Pro Gln Asp Leu Lys Leu Arg Asp Val Thr His Ser 
                405                 410                 415     


Thr Met Asn Val Phe Trp Glu Pro Val Pro Gly Lys Val Arg Lys Tyr 
            420                 425                 430         


Ile Val Arg Tyr Lys Thr Pro Glu Glu Asp Val Lys Glu Val Glu Val 
        435                 440                 445             


Asp Arg Ser Glu Thr Ser Thr Ser Leu Lys Asp Leu Phe Ser Gln Thr 
    450                 455                 460                 


Leu Tyr Thr Val Ser Val Ser Ala Val His Asp Glu Gly Glu Ser Pro 
465                 470                 475                 480 


Pro Val Thr Ala Gln Glu Thr Thr Arg Pro Val Pro Ala Pro Thr Asn 
                485                 490                 495     


Leu Lys Ile Thr Glu Val Thr Ser Glu Gly Phe Arg Gly Thr Trp Asp 
            500                 505                 510         


His Gly Ala Ser Asp Val Ser Leu Tyr Arg Ile Thr Trp Ala Pro Phe 
        515                 520                 525             


Gly Ser Ser Asp Lys Met Glu Thr Ile Leu Asn Gly Asp Glu Asn Thr 
    530                 535                 540                 


Leu Val Phe Glu Asn Leu Asn Pro Asn Thr Ile Tyr Glu Val Ser Ile 
545                 550                 555                 560 


Thr Ala Ile Tyr Pro Asp Glu Ser Glu Ser Asp Asp Leu Ile Gly Ser 
                565                 570                 575     


Glu Arg Thr Leu Pro Ile Leu Thr Thr Gln Ala Pro Lys Ser Gly Pro 
            580                 585                 590         


Arg Asn Leu Gln Val Tyr Asn Ala Thr Ser Asn Ser Leu Thr Val Lys 
        595                 600                 605             


Trp Asp Pro Ala Ser Gly Arg Val Gln Lys Tyr Arg Ile Thr Tyr Gln 
    610                 615                 620                 


Pro Ser Thr Gly Glu Gly Asn Glu Gln Thr Thr Thr Ile Gly Gly Arg 
625                 630                 635                 640 


Gln Asn Ser Val Val Leu Gln Lys Leu Lys Pro Asp Thr Pro Tyr Thr 
                645                 650                 655     


Ile Thr Val Ser Ser Leu Tyr Pro Asp Gly Glu Gly Gly Arg Met Thr 
            660                 665                 670         


Gly Arg Gly Lys Thr Lys Pro Leu Asn Thr Val Arg Asn Leu Arg Val 
        675                 680                 685             


Tyr Asp Pro Ser Thr Ser Thr Leu Asn Val Arg Trp Asp His Ala Glu 
    690                 695                 700                 


Gly Asn Pro Arg Gln Tyr Lys Leu Phe Tyr Ala Pro Ala Ala Gly Gly 
705                 710                 715                 720 


Pro Glu Glu Leu Val Pro Ile Pro Gly Asn Thr Asn Tyr Ala Ile Leu 
                725                 730                 735     


Arg Asn Leu Gln Pro Asp Thr Ser Tyr Thr Val Thr Val Val Pro Val 
            740                 745                 750         


Tyr Thr Glu Gly Asp Gly Gly Arg Thr Ser Asp Thr Gly Arg Thr Leu 
        755                 760                 765             


Met Arg Gly Leu Ala Arg Asn Val Gln Val Tyr Asn Pro Thr Pro Asn 
    770                 775                 780                 


Ser Leu Asp Val Arg Trp Asp Pro Ala Pro Gly Pro Val Leu Gln Tyr 
785                 790                 795                 800 


Arg Val Val Tyr Ser Pro Val Asp Gly Thr Arg Pro Ser Glu Ser Ile 
                805                 810                 815     


Val Val Pro Gly Asn Thr Arg Met Val His Leu Glu Arg Leu Ile Pro 
            820                 825                 830         


Asp Thr Leu Tyr Ser Val Asn Leu Val Ala Leu Tyr Ser Asp Gly Glu 
        835                 840                 845             


Gly Asn Pro Ser Pro Ala Gln Gly Arg Thr Leu Pro Arg Ser Gly Pro 
    850                 855                 860                 


Arg Asn Leu Arg Val Phe Gly Glu Thr Thr Asn Ser Leu Ser Val Ala 
865                 870                 875                 880 


Trp Asp His Ala Asp Gly Pro Val Gln Gln Tyr Arg Ile Ile Tyr Ser 
                885                 890                 895     


Pro Thr Val Gly Asp Pro Ile Asp Glu Tyr Thr Thr Val Pro Gly Arg 
            900                 905                 910         


Arg Asn Asn Val Ile Leu Gln Pro Leu Gln Pro Asp Thr Pro Tyr Lys 
        915                 920                 925             


Ile Thr Val Ile Ala Val Tyr Glu Asp Gly Asp Gly Gly His Leu Thr 
    930                 935                 940                 


Gly Asn Gly Arg Thr Val Gly Leu Leu Pro Pro Gln Asn Ile His Ile 
945                 950                 955                 960 


Ser Asp Glu Trp Tyr Thr Arg Phe Arg Val Ser Trp Asp Pro Ser Pro 
                965                 970                 975     


Ser Pro Val Leu Gly Tyr Lys Ile Val Tyr Lys Pro Val Gly Ser Asn 
            980                 985                 990         


Glu Pro Met Glu Ala Phe Val Gly  Glu Met Thr Ser Tyr  Thr Leu His 
        995                 1000                 1005             


Asn Leu  Asn Pro Ser Thr Thr  Tyr Asp Val Asn Val  Tyr Ala Gln 
    1010                 1015                 1020             


Tyr Asp  Ser Gly Leu Ser Val  Pro Leu Thr Asp Gln  Gly Thr Thr 
    1025                 1030                 1035             


Leu Tyr  Leu Asn Val Thr Asp  Leu Lys Thr Tyr Gln  Ile Gly Trp 
    1040                 1045                 1050             


Asp Thr  Phe Cys Val Lys Trp  Ser Pro His Arg Ala  Ala Thr Ser 
    1055                 1060                 1065             


Tyr Arg  Leu Lys Leu Ser Pro  Ala Asp Gly Thr Arg  Gly Gln Glu 
    1070                 1075                 1080             


Ile Thr  Val Arg Gly Ser Glu  Thr Ser His Cys Phe  Thr Gly Leu 
    1085                 1090                 1095             


Ser Pro  Asp Thr Asp Tyr Gly  Val Thr Val Phe Val  Gln Thr Pro 
    1100                 1105                 1110             


Asn Leu  Glu Gly Pro Gly Val  Ser Val Lys Glu His  Thr Thr Val 
    1115                 1120                 1125             


Lys Pro  Thr Glu Ala Pro Thr  Glu Pro Pro Thr Pro  Pro Pro Pro 
    1130                 1135                 1140             


Pro Thr  Ile Pro Pro Ala Arg  Asp Val Cys Lys Gly  Ala Lys Ala 
    1145                 1150                 1155             


Asp Ile  Val Phe Leu Thr Asp  Ala Ser Trp Ser Ile  Gly Asp Asp 
    1160                 1165                 1170             


Asn Phe  Asn Lys Val Val Lys  Phe Ile Phe Asn Thr  Val Gly Gly 
    1175                 1180                 1185             


Phe Asp  Glu Ile Ser Pro Ala  Gly Ile Gln Val Ser  Phe Val Gln 
    1190                 1195                 1200             


Tyr Ser  Asp Glu Val Lys Ser  Glu Phe Lys Leu Asn  Thr Tyr Asn 
    1205                 1210                 1215             


Asp Lys  Ala Leu Ala Leu Gly  Ala Leu Gln Asn Ile  Arg Tyr Arg 
    1220                 1225                 1230             


Gly Gly  Asn Thr Arg Thr Gly  Lys Ala Leu Thr Phe  Ile Lys Glu 
    1235                 1240                 1245             


Lys Val  Leu Thr Trp Glu Ser  Gly Met Arg Lys Asn  Val Pro Lys 
    1250                 1255                 1260             


Val Leu  Val Val Val Thr Asp  Gly Arg Ser Gln Asp  Glu Val Lys 
    1265                 1270                 1275             


Lys Ala  Ala Leu Val Ile Gln  Gln Ser Gly Phe Ser  Val Phe Val 
    1280                 1285                 1290             


Val Gly  Val Ala Asp Val Asp  Tyr Asn Glu Leu Ala  Asn Ile Ala 
    1295                 1300                 1305             


Ser Lys  Pro Ser Glu Arg His  Val Phe Ile Val Asp  Asp Phe Glu 
    1310                 1315                 1320             


Ser Phe  Glu Lys Ile Glu Asp  Asn Leu Ile Thr Phe  Val Cys Glu 
    1325                 1330                 1335             


Thr Ala  Thr Ser Ser Cys Pro  Leu Ile Tyr Leu Asp  Gly Tyr Thr 
    1340                 1345                 1350             


Ser Pro  Gly Phe Lys Met Leu  Glu Ala Tyr Asn Leu  Thr Glu Lys 
    1355                 1360                 1365             


Asn Phe  Ala Ser Val Gln Gly  Val Ser Leu Glu Ser  Gly Ser Phe 
    1370                 1375                 1380             


Pro Ser  Tyr Ser Ala Tyr Arg  Ile Gln Lys Asn Ala  Phe Val Asn 
    1385                 1390                 1395             


Gln Pro  Thr Ala Asp Leu His  Pro Asn Gly Leu Pro  Pro Ser Tyr 
    1400                 1405                 1410             


Thr Ile  Ile Leu Leu Phe Arg  Leu Leu Pro Glu Thr  Pro Ser Asp 
    1415                 1420                 1425             


Pro Phe  Ala Ile Trp Gln Ile  Thr Asp Arg Asp Tyr  Lys Pro Gln 
    1430                 1435                 1440             


Val Gly  Val Ile Ala Asp Pro  Ser Ser Lys Thr Leu  Ser Phe Phe 
    1445                 1450                 1455             


Asn Lys  Asp Thr Arg Gly Glu  Val Gln Thr Val Thr  Phe Asp Thr 
    1460                 1465                 1470             


Glu Glu  Val Lys Thr Leu Phe  Tyr Gly Ser Phe His  Lys Val His 
    1475                 1480                 1485             


Ile Val  Val Thr Ser Lys Ser  Val Lys Ile Tyr Ile  Asp Cys Tyr 
    1490                 1495                 1500             


Glu Ile  Ile Glu Lys Asp Ile  Lys Glu Ala Gly Asn  Ile Thr Thr 
    1505                 1510                 1515             


Asp Gly  Tyr Glu Ile Leu Gly  Lys Leu Leu Lys Gly  Glu Arg Lys 
    1520                 1525                 1530             


Ser Ala  Ala Phe Gln Ile Gln  Ser Phe Asp Ile Val  Cys Ser Pro 
    1535                 1540                 1545             


Val Trp  Thr Ser Arg Asp Arg  Cys Cys Asp Ile Pro  Ser Arg Arg 
    1550                 1555                 1560             


Asp Glu  Gly Lys Cys Pro Ala  Phe Pro Asn Ser Cys  Thr Cys Thr 
    1565                 1570                 1575             


Gln Asp  Ser Val Gly Pro Pro  Gly Pro Pro Gly Pro  Ala Gly Gly 
    1580                 1585                 1590             


Pro Gly  Ala Lys Gly Pro Arg  Gly Glu Arg Gly Ile  Ser Gly Ala 
    1595                 1600                 1605             


Ile Gly  Pro Pro Gly Pro Arg  Gly Asp Ile Gly Pro  Pro Gly Pro 
    1610                 1615                 1620             


Gln Gly  Pro Pro Gly Pro Gln  Gly Pro Asn Gly Leu  Ser Ile Pro 
    1625                 1630                 1635             


Gly Glu  Gln Gly Arg Gln Gly  Met Lys Gly Asp Ala  Gly Glu Pro 
    1640                 1645                 1650             


Gly Leu  Pro Gly Arg Thr Gly  Thr Pro Gly Leu Pro  Gly Pro Pro 
    1655                 1660                 1665             


Gly Pro  Met Gly Pro Pro Gly  Asp Arg Gly Phe Thr  Gly Lys Asp 
    1670                 1675                 1680             


Gly Ala  Met Gly Pro Arg Gly  Pro Pro Gly Pro Pro  Gly Ser Pro 
    1685                 1690                 1695             


Gly Ser  Pro Gly Val Thr Gly  Pro Ser Gly Lys Pro  Gly Lys Pro 
    1700                 1705                 1710             


Gly Asp  His Gly Arg Pro Gly  Pro Ser Gly Leu Lys  Gly Glu Lys 
    1715                 1720                 1725             


Gly Asp  Arg Gly Asp Ile Ala  Ser Gln Asn Met Met  Arg Ala Val 
    1730                 1735                 1740             


Ala Arg  Gln Val Cys Glu Gln  Leu Ile Ser Gly Gln  Met Asn Arg 
    1745                 1750                 1755             


Phe Asn  Gln Met Leu Asn Gln  Ile Pro Asn Asp Tyr  Gln Ser Ser 
    1760                 1765                 1770             


Arg Asn  Gln Pro Gly Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Ser 
    1775                 1780                 1785             


Ala Gly  Ala Arg Gly Glu Pro  Gly Pro Gly Gly Arg  Pro Gly Phe 
    1790                 1795                 1800             


Pro Gly  Thr Pro Gly Met Gln  Gly Pro Pro Gly Glu  Arg Gly Leu 
    1805                 1810                 1815             


Pro Gly  Glu Lys Gly Glu Arg  Gly Thr Gly Ser Ser  Gly Pro Arg 
    1820                 1825                 1830             


Gly Leu  Pro Gly Pro Pro Gly  Pro Gln Gly Glu Ser  Arg Thr Gly 
    1835                 1840                 1845             


Pro Pro  Gly Ser Thr Gly Ser  Arg Gly Pro Pro Gly  Pro Pro Gly 
    1850                 1855                 1860             


Arg Pro  Gly Asn Ser Gly Ile  Arg Gly Pro Pro Gly  Pro Pro Gly 
    1865                 1870                 1875             


Tyr Cys  Asp Ser Ser Gln Cys  Ala Ser Ile Pro Tyr  Asn Gly Gln 
    1880                 1885                 1890             


Gly Tyr  Pro Gly Ser Gly 
    1895                 


<210>  3225
<211>  3063
<212>  PRT
<213>  Homo Sapiens

<400>  3225

Met Arg Ser Arg Leu Pro Pro Ala Leu Ala Ala Leu Gly Ala Ala Leu 
1               5                   10                  15      


Leu Leu Ser Ser Ile Glu Ala Glu Val Asp Pro Pro Ser Asp Leu Asn 
            20                  25                  30          


Phe Lys Ile Ile Asp Glu Asn Thr Val His Met Ser Trp Ala Lys Pro 
        35                  40                  45              


Val Asp Pro Ile Val Gly Tyr Arg Ile Thr Val Asp Pro Thr Thr Asp 
    50                  55                  60                  


Gly Pro Thr Lys Glu Phe Thr Leu Ser Ala Ser Thr Thr Glu Thr Leu 
65                  70                  75                  80  


Leu Ser Glu Leu Val Pro Glu Thr Glu Tyr Val Val Thr Ile Thr Ser 
                85                  90                  95      


Tyr Asp Glu Val Glu Glu Ser Val Pro Val Ile Gly Gln Leu Thr Ile 
            100                 105                 110         


Gln Thr Gly Ser Ser Thr Lys Pro Val Glu Lys Lys Pro Gly Lys Thr 
        115                 120                 125             


Glu Ile Gln Lys Cys Ser Val Ser Ala Trp Thr Asp Leu Val Phe Leu 
    130                 135                 140                 


Val Asp Gly Ser Trp Ser Val Gly Arg Asn Asn Phe Lys Tyr Ile Leu 
145                 150                 155                 160 


Asp Phe Ile Ala Ala Leu Val Ser Ala Phe Asp Ile Gly Glu Glu Lys 
                165                 170                 175     


Thr Arg Val Gly Val Val Gln Tyr Ser Ser Asp Thr Arg Thr Glu Phe 
            180                 185                 190         


Asn Leu Asn Gln Tyr Tyr Gln Arg Asp Glu Leu Leu Ala Ala Ile Lys 
        195                 200                 205             


Lys Ile Pro Tyr Lys Gly Gly Asn Thr Met Thr Gly Asp Ala Ile Asp 
    210                 215                 220                 


Tyr Leu Val Lys Asn Thr Phe Thr Glu Ser Ala Gly Ala Arg Val Gly 
225                 230                 235                 240 


Phe Pro Lys Val Ala Ile Ile Ile Thr Asp Gly Lys Ser Gln Asp Glu 
                245                 250                 255     


Val Glu Ile Pro Ala Arg Glu Leu Arg Asn Val Gly Val Glu Val Phe 
            260                 265                 270         


Ser Leu Gly Ile Lys Ala Ala Asp Ala Lys Glu Leu Lys Gln Ile Ala 
        275                 280                 285             


Ser Thr Pro Ser Leu Asn His Val Phe Asn Val Ala Asn Phe Asp Ala 
    290                 295                 300                 


Ile Val Asp Ile Gln Asn Glu Ile Ile Ser Gln Val Cys Ser Gly Val 
305                 310                 315                 320 


Asp Glu Gln Leu Gly Glu Leu Val Ser Gly Glu Glu Val Val Glu Pro 
                325                 330                 335     


Pro Ser Asn Leu Ile Ala Met Glu Val Ser Ser Lys Tyr Val Lys Leu 
            340                 345                 350         


Asn Trp Asn Pro Ser Pro Ser Pro Val Thr Gly Tyr Lys Val Ile Leu 
        355                 360                 365             


Thr Pro Met Thr Ala Gly Ser Arg Gln His Ala Leu Ser Val Gly Pro 
    370                 375                 380                 


Gln Thr Thr Thr Leu Ser Val Arg Asp Leu Ser Ala Asp Thr Glu Tyr 
385                 390                 395                 400 


Gln Ile Ser Val Ser Ala Met Lys Gly Met Thr Ser Ser Glu Pro Ile 
                405                 410                 415     


Ser Ile Met Glu Lys Thr Gln Pro Met Lys Val Gln Val Glu Cys Ser 
            420                 425                 430         


Arg Gly Val Asp Ile Lys Ala Asp Ile Val Phe Leu Val Asp Gly Ser 
        435                 440                 445             


Tyr Ser Ile Gly Ile Ala Asn Phe Val Lys Val Arg Ala Phe Leu Glu 
    450                 455                 460                 


Val Leu Val Lys Ser Phe Glu Ile Ser Pro Asn Arg Val Gln Ile Ser 
465                 470                 475                 480 


Leu Val Gln Tyr Ser Arg Asp Pro His Thr Glu Phe Thr Leu Lys Lys 
                485                 490                 495     


Phe Thr Lys Val Glu Asp Ile Ile Glu Ala Ile Asn Thr Phe Pro Tyr 
            500                 505                 510         


Arg Gly Gly Ser Thr Asn Thr Gly Lys Ala Met Thr Tyr Val Arg Glu 
        515                 520                 525             


Lys Ile Phe Val Pro Ser Lys Gly Ser Arg Ser Asn Val Pro Lys Val 
    530                 535                 540                 


Met Ile Leu Ile Thr Asp Gly Lys Ser Ser Asp Ala Phe Arg Asp Pro 
545                 550                 555                 560 


Ala Ile Lys Leu Arg Asn Ser Asp Val Glu Ile Phe Ala Val Gly Val 
                565                 570                 575     


Lys Asp Ala Val Arg Ser Glu Leu Glu Ala Ile Ala Ser Pro Pro Ala 
            580                 585                 590         


Glu Thr His Val Phe Thr Val Glu Asp Phe Asp Ala Phe Gln Arg Ile 
        595                 600                 605             


Ser Phe Glu Leu Thr Gln Ser Ile Cys Leu Arg Ile Glu Gln Glu Leu 
    610                 615                 620                 


Ala Ala Ile Lys Lys Lys Ala Tyr Val Pro Pro Lys Asp Leu Ser Phe 
625                 630                 635                 640 


Ser Glu Val Thr Ser Tyr Gly Phe Lys Thr Asn Trp Ser Pro Ala Gly 
                645                 650                 655     


Glu Asn Val Phe Ser Tyr His Ile Thr Tyr Lys Glu Ala Ala Gly Asp 
            660                 665                 670         


Asp Glu Val Thr Val Val Glu Pro Ala Ser Ser Thr Ser Val Val Leu 
        675                 680                 685             


Ser Ser Leu Lys Pro Glu Thr Leu Tyr Leu Val Asn Val Thr Ala Glu 
    690                 695                 700                 


Tyr Glu Asp Gly Phe Ser Ile Pro Leu Ala Gly Glu Glu Thr Thr Glu 
705                 710                 715                 720 


Glu Val Lys Gly Ala Pro Arg Asn Leu Lys Val Thr Asp Glu Thr Thr 
                725                 730                 735     


Asp Ser Phe Lys Ile Thr Trp Thr Gln Ala Pro Gly Arg Val Leu Arg 
            740                 745                 750         


Tyr Arg Ile Ile Tyr Arg Pro Val Ala Gly Gly Glu Ser Arg Glu Val 
        755                 760                 765             


Thr Thr Pro Pro Asn Gln Arg Arg Arg Thr Leu Glu Asn Leu Ile Pro 
    770                 775                 780                 


Asp Thr Lys Tyr Glu Val Ser Val Ile Pro Glu Tyr Phe Ser Gly Pro 
785                 790                 795                 800 


Gly Thr Pro Leu Thr Gly Asn Ala Ala Thr Glu Glu Val Arg Gly Asn 
                805                 810                 815     


Pro Arg Asp Leu Arg Val Ser Asp Pro Thr Thr Ser Thr Met Lys Leu 
            820                 825                 830         


Ser Trp Ser Gly Ala Pro Gly Lys Val Lys Gln Tyr Leu Val Thr Tyr 
        835                 840                 845             


Thr Pro Val Ala Gly Gly Glu Thr Gln Glu Val Thr Val Arg Gly Asp 
    850                 855                 860                 


Thr Thr Asn Thr Val Leu Gln Gly Leu Lys Glu Gly Thr Gln Tyr Ala 
865                 870                 875                 880 


Leu Ser Val Thr Ala Leu Tyr Ala Ser Gly Ala Gly Asp Ala Leu Phe 
                885                 890                 895     


Gly Glu Gly Thr Thr Leu Glu Glu Arg Gly Ser Pro Gln Asp Leu Val 
            900                 905                 910         


Thr Lys Asp Ile Thr Asp Thr Ser Ile Gly Ala Tyr Trp Thr Ser Ala 
        915                 920                 925             


Pro Gly Met Val Arg Gly Tyr Arg Val Ser Trp Lys Ser Leu Tyr Asp 
    930                 935                 940                 


Asp Val Asp Thr Gly Glu Lys Asn Leu Pro Glu Asp Ala Ile His Thr 
945                 950                 955                 960 


Met Ile Glu Asn Leu Gln Pro Glu Thr Lys Tyr Arg Ile Ser Val Phe 
                965                 970                 975     


Ala Thr Tyr Ser Ser Gly Glu Gly Glu Pro Leu Thr Gly Asp Ala Thr 
            980                 985                 990         


Thr Glu Leu Ser Gln Asp Ser Lys  Thr Leu Lys Val Asp  Glu Glu Thr 
        995                 1000                 1005             


Glu Asn  Thr Met Arg Val Thr  Trp Lys Pro Ala Pro  Gly Lys Val 
    1010                 1015                 1020             


Val Asn  Tyr Arg Val Val Tyr  Arg Pro His Gly Arg  Gly Lys Gln 
    1025                 1030                 1035             


Met Val  Ala Lys Val Pro Pro  Thr Val Thr Ser Thr  Val Leu Lys 
    1040                 1045                 1050             


Arg Leu  Gln Pro Gln Thr Thr  Tyr Asp Ile Thr Val  Leu Pro Ile 
    1055                 1060                 1065             


Tyr Lys  Met Gly Glu Gly Lys  Leu Arg Gln Gly Ser  Gly Thr Thr 
    1070                 1075                 1080             


Ala Ser  Arg Phe Lys Ser Pro  Arg Asn Leu Lys Thr  Ser Asp Pro 
    1085                 1090                 1095             


Thr Met  Ser Ser Phe Arg Val  Thr Trp Glu Pro Ala  Pro Gly Glu 
    1100                 1105                 1110             


Val Lys  Gly Tyr Lys Val Thr  Phe His Pro Thr Gly  Asp Asp Arg 
    1115                 1120                 1125             


Arg Leu  Gly Glu Leu Val Val  Gly Pro Tyr Asp Asn  Thr Val Val 
    1130                 1135                 1140             


Leu Glu  Glu Leu Arg Ala Gly  Thr Thr Tyr Lys Val  Asn Val Phe 
    1145                 1150                 1155             


Gly Met  Phe Asp Gly Gly Glu  Ser Ser Pro Leu Val  Gly Gln Glu 
    1160                 1165                 1170             


Met Thr  Thr Leu Ser Asp Thr  Thr Val Met Pro Ile  Leu Ser Ser 
    1175                 1180                 1185             


Gly Met  Glu Cys Leu Thr Arg  Ala Glu Ala Asp Ile  Val Leu Leu 
    1190                 1195                 1200             


Val Asp  Gly Ser Trp Ser Ile  Gly Arg Ala Asn Phe  Arg Thr Val 
    1205                 1210                 1215             


Arg Ser  Phe Ile Ser Arg Ile  Val Glu Val Phe Asp  Ile Gly Pro 
    1220                 1225                 1230             


Lys Arg  Val Gln Ile Ala Leu  Ala Gln Tyr Ser Gly  Asp Pro Arg 
    1235                 1240                 1245             


Thr Glu  Trp Gln Leu Asn Ala  His Arg Asp Lys Lys  Ser Leu Leu 
    1250                 1255                 1260             


Gln Ala  Val Ala Asn Leu Pro  Tyr Lys Gly Gly Asn  Thr Leu Thr 
    1265                 1270                 1275             


Gly Met  Ala Leu Asn Phe Ile  Arg Gln Gln Asn Phe  Arg Thr Gln 
    1280                 1285                 1290             


Ala Gly  Met Arg Pro Arg Ala  Arg Lys Ile Gly Val  Leu Ile Thr 
    1295                 1300                 1305             


Asp Gly  Lys Ser Gln Asp Asp  Val Glu Ala Pro Ser  Lys Lys Leu 
    1310                 1315                 1320             


Lys Asp  Glu Gly Val Glu Leu  Phe Ala Ile Gly Ile  Lys Asn Ala 
    1325                 1330                 1335             


Asp Glu  Val Glu Leu Lys Met  Ile Ala Thr Asp Pro  Asp Asp Thr 
    1340                 1345                 1350             


His Ala  Tyr Asn Val Ala Asp  Phe Glu Ser Leu Ser  Arg Ile Val 
    1355                 1360                 1365             


Asp Asp  Leu Thr Ile Asn Leu  Cys Asn Ser Val Lys  Gly Pro Gly 
    1370                 1375                 1380             


Asp Leu  Glu Ala Pro Ser Asn  Leu Val Ile Ser Glu  Arg Thr His 
    1385                 1390                 1395             


Arg Ser  Phe Arg Val Ser Trp  Thr Pro Pro Ser Asp  Ser Val Asp 
    1400                 1405                 1410             


Arg Tyr  Lys Val Glu Tyr Tyr  Pro Val Ser Gly Gly  Lys Arg Gln 
    1415                 1420                 1425             


Glu Phe  Tyr Val Ser Arg Met  Glu Thr Ser Thr Val  Leu Lys Asp 
    1430                 1435                 1440             


Leu Lys  Pro Glu Thr Glu Tyr  Val Val Asn Val Tyr  Ser Val Val 
    1445                 1450                 1455             


Glu Asp  Glu Tyr Ser Glu Pro  Leu Lys Gly Thr Glu  Lys Thr Leu 
    1460                 1465                 1470             


Pro Val  Pro Val Val Ser Leu  Asn Ile Tyr Asp Val  Gly Pro Thr 
    1475                 1480                 1485             


Thr Met  His Val Gln Trp Gln  Pro Val Gly Gly Ala  Thr Gly Tyr 
    1490                 1495                 1500             


Ile Leu  Ser Tyr Lys Pro Val  Lys Asp Thr Glu Pro  Thr Arg Pro 
    1505                 1510                 1515             


Lys Glu  Val Arg Leu Gly Pro  Thr Val Asn Asp Met  Gln Leu Thr 
    1520                 1525                 1530             


Asp Leu  Val Pro Asn Thr Glu  Tyr Ala Val Thr Val  Gln Ala Val 
    1535                 1540                 1545             


Leu His  Asp Leu Thr Ser Glu  Pro Val Thr Val Arg  Glu Val Thr 
    1550                 1555                 1560             


Leu Pro  Leu Pro Arg Pro Gln  Asp Leu Lys Leu Arg  Asp Val Thr 
    1565                 1570                 1575             


His Ser  Thr Met Asn Val Phe  Trp Glu Pro Val Pro  Gly Lys Val 
    1580                 1585                 1590             


Arg Lys  Tyr Ile Val Arg Tyr  Lys Thr Pro Glu Glu  Asp Val Lys 
    1595                 1600                 1605             


Glu Val  Glu Val Asp Arg Ser  Glu Thr Ser Thr Ser  Leu Lys Asp 
    1610                 1615                 1620             


Leu Phe  Ser Gln Thr Leu Tyr  Thr Val Ser Val Ser  Ala Val His 
    1625                 1630                 1635             


Asp Glu  Gly Glu Ser Pro Pro  Val Thr Ala Gln Glu  Thr Thr Arg 
    1640                 1645                 1650             


Pro Val  Pro Ala Pro Thr Asn  Leu Lys Ile Thr Glu  Val Thr Ser 
    1655                 1660                 1665             


Glu Gly  Phe Arg Gly Thr Trp  Asp His Gly Ala Ser  Asp Val Ser 
    1670                 1675                 1680             


Leu Tyr  Arg Ile Thr Trp Ala  Pro Phe Gly Ser Ser  Asp Lys Met 
    1685                 1690                 1695             


Glu Thr  Ile Leu Asn Gly Asp  Glu Asn Thr Leu Val  Phe Glu Asn 
    1700                 1705                 1710             


Leu Asn  Pro Asn Thr Ile Tyr  Glu Val Ser Ile Thr  Ala Ile Tyr 
    1715                 1720                 1725             


Pro Asp  Glu Ser Glu Ser Asp  Asp Leu Ile Gly Ser  Glu Arg Thr 
    1730                 1735                 1740             


Leu Pro  Ile Leu Thr Thr Gln  Ala Pro Lys Ser Gly  Pro Arg Asn 
    1745                 1750                 1755             


Leu Gln  Val Tyr Asn Ala Thr  Ser Asn Ser Leu Thr  Val Lys Trp 
    1760                 1765                 1770             


Asp Pro  Ala Ser Gly Arg Val  Gln Lys Tyr Arg Ile  Thr Tyr Gln 
    1775                 1780                 1785             


Pro Ser  Thr Gly Glu Gly Asn  Glu Gln Thr Thr Thr  Ile Gly Gly 
    1790                 1795                 1800             


Arg Gln  Asn Ser Val Val Leu  Gln Lys Leu Lys Pro  Asp Thr Pro 
    1805                 1810                 1815             


Tyr Thr  Ile Thr Val Ser Ser  Leu Tyr Pro Asp Gly  Glu Gly Gly 
    1820                 1825                 1830             


Arg Met  Thr Gly Arg Gly Lys  Thr Lys Pro Leu Asn  Thr Val Arg 
    1835                 1840                 1845             


Asn Leu  Arg Val Tyr Asp Pro  Ser Thr Ser Thr Leu  Asn Val Arg 
    1850                 1855                 1860             


Trp Asp  His Ala Glu Gly Asn  Pro Arg Gln Tyr Lys  Leu Phe Tyr 
    1865                 1870                 1875             


Ala Pro  Ala Ala Gly Gly Pro  Glu Glu Leu Val Pro  Ile Pro Gly 
    1880                 1885                 1890             


Asn Thr  Asn Tyr Ala Ile Leu  Arg Asn Leu Gln Pro  Asp Thr Ser 
    1895                 1900                 1905             


Tyr Thr  Val Thr Val Val Pro  Val Tyr Thr Glu Gly  Asp Gly Gly 
    1910                 1915                 1920             


Arg Thr  Ser Asp Thr Gly Arg  Thr Leu Met Arg Gly  Leu Ala Arg 
    1925                 1930                 1935             


Asn Val  Gln Val Tyr Asn Pro  Thr Pro Asn Ser Leu  Asp Val Arg 
    1940                 1945                 1950             


Trp Asp  Pro Ala Pro Gly Pro  Val Leu Gln Tyr Arg  Val Val Tyr 
    1955                 1960                 1965             


Ser Pro  Val Asp Gly Thr Arg  Pro Ser Glu Ser Ile  Val Val Pro 
    1970                 1975                 1980             


Gly Asn  Thr Arg Met Val His  Leu Glu Arg Leu Ile  Pro Asp Thr 
    1985                 1990                 1995             


Leu Tyr  Ser Val Asn Leu Val  Ala Leu Tyr Ser Asp  Gly Glu Gly 
    2000                 2005                 2010             


Asn Pro  Ser Pro Ala Gln Gly  Arg Thr Leu Pro Arg  Ser Gly Pro 
    2015                 2020                 2025             


Arg Asn  Leu Arg Val Phe Gly  Glu Thr Thr Asn Ser  Leu Ser Val 
    2030                 2035                 2040             


Ala Trp  Asp His Ala Asp Gly  Pro Val Gln Gln Tyr  Arg Ile Ile 
    2045                 2050                 2055             


Tyr Ser  Pro Thr Val Gly Asp  Pro Ile Asp Glu Tyr  Thr Thr Val 
    2060                 2065                 2070             


Pro Gly  Arg Arg Asn Asn Val  Ile Leu Gln Pro Leu  Gln Pro Asp 
    2075                 2080                 2085             


Thr Pro  Tyr Lys Ile Thr Val  Ile Ala Val Tyr Glu  Asp Gly Asp 
    2090                 2095                 2100             


Gly Gly  His Leu Thr Gly Asn  Gly Arg Thr Val Gly  Leu Leu Pro 
    2105                 2110                 2115             


Pro Gln  Asn Ile His Ile Ser  Asp Glu Trp Tyr Thr  Arg Phe Arg 
    2120                 2125                 2130             


Val Ser  Trp Asp Pro Ser Pro  Ser Pro Val Leu Gly  Tyr Lys Ile 
    2135                 2140                 2145             


Val Tyr  Lys Pro Val Gly Ser  Asn Glu Pro Met Glu  Ala Phe Val 
    2150                 2155                 2160             


Gly Glu  Met Thr Ser Tyr Thr  Leu His Asn Leu Asn  Pro Ser Thr 
    2165                 2170                 2175             


Thr Tyr  Asp Val Asn Val Tyr  Ala Gln Tyr Asp Ser  Gly Leu Ser 
    2180                 2185                 2190             


Val Pro  Leu Thr Asp Gln Gly  Thr Thr Leu Tyr Leu  Asn Val Thr 
    2195                 2200                 2205             


Asp Leu  Lys Thr Tyr Gln Ile  Gly Trp Asp Thr Phe  Cys Val Lys 
    2210                 2215                 2220             


Trp Ser  Pro His Arg Ala Ala  Thr Ser Tyr Arg Leu  Lys Leu Ser 
    2225                 2230                 2235             


Pro Ala  Asp Gly Thr Arg Gly  Gln Glu Ile Thr Val  Arg Gly Ser 
    2240                 2245                 2250             


Glu Thr  Ser His Cys Phe Thr  Gly Leu Ser Pro Asp  Thr Asp Tyr 
    2255                 2260                 2265             


Gly Val  Thr Val Phe Val Gln  Thr Pro Asn Leu Glu  Gly Pro Gly 
    2270                 2275                 2280             


Val Ser  Val Lys Glu His Thr  Thr Val Lys Pro Thr  Glu Ala Pro 
    2285                 2290                 2295             


Thr Glu  Pro Pro Thr Pro Pro  Pro Pro Pro Thr Ile  Pro Pro Ala 
    2300                 2305                 2310             


Arg Asp  Val Cys Lys Gly Ala  Lys Ala Asp Ile Val  Phe Leu Thr 
    2315                 2320                 2325             


Asp Ala  Ser Trp Ser Ile Gly  Asp Asp Asn Phe Asn  Lys Val Val 
    2330                 2335                 2340             


Lys Phe  Ile Phe Asn Thr Val  Gly Gly Phe Asp Glu  Ile Ser Pro 
    2345                 2350                 2355             


Ala Gly  Ile Gln Val Ser Phe  Val Gln Tyr Ser Asp  Glu Val Lys 
    2360                 2365                 2370             


Ser Glu  Phe Lys Leu Asn Thr  Tyr Asn Asp Lys Ala  Leu Ala Leu 
    2375                 2380                 2385             


Gly Ala  Leu Gln Asn Ile Arg  Tyr Arg Gly Gly Asn  Thr Arg Thr 
    2390                 2395                 2400             


Gly Lys  Ala Leu Thr Phe Ile  Lys Glu Lys Val Leu  Thr Trp Glu 
    2405                 2410                 2415             


Ser Gly  Met Arg Lys Asn Val  Pro Lys Val Leu Val  Val Val Thr 
    2420                 2425                 2430             


Asp Gly  Arg Ser Gln Asp Glu  Val Lys Lys Ala Ala  Leu Val Ile 
    2435                 2440                 2445             


Gln Gln  Ser Gly Phe Ser Val  Phe Val Val Gly Val  Ala Asp Val 
    2450                 2455                 2460             


Asp Tyr  Asn Glu Leu Ala Asn  Ile Ala Ser Lys Pro  Ser Glu Arg 
    2465                 2470                 2475             


His Val  Phe Ile Val Asp Asp  Phe Glu Ser Phe Glu  Lys Ile Glu 
    2480                 2485                 2490             


Asp Asn  Leu Ile Thr Phe Val  Cys Glu Thr Ala Thr  Ser Ser Cys 
    2495                 2500                 2505             


Pro Leu  Ile Tyr Leu Asp Gly  Tyr Thr Ser Pro Gly  Phe Lys Met 
    2510                 2515                 2520             


Leu Glu  Ala Tyr Asn Leu Thr  Glu Lys Asn Phe Ala  Ser Val Gln 
    2525                 2530                 2535             


Gly Val  Ser Leu Glu Ser Gly  Ser Phe Pro Ser Tyr  Ser Ala Tyr 
    2540                 2545                 2550             


Arg Ile  Gln Lys Asn Ala Phe  Val Asn Gln Pro Thr  Ala Asp Leu 
    2555                 2560                 2565             


His Pro  Asn Gly Leu Pro Pro  Ser Tyr Thr Ile Ile  Leu Leu Phe 
    2570                 2575                 2580             


Arg Leu  Leu Pro Glu Thr Pro  Ser Asp Pro Phe Ala  Ile Trp Gln 
    2585                 2590                 2595             


Ile Thr  Asp Arg Asp Tyr Lys  Pro Gln Val Gly Val  Ile Ala Asp 
    2600                 2605                 2610             


Pro Ser  Ser Lys Thr Leu Ser  Phe Phe Asn Lys Asp  Thr Arg Gly 
    2615                 2620                 2625             


Glu Val  Gln Thr Val Thr Phe  Asp Thr Glu Glu Val  Lys Thr Leu 
    2630                 2635                 2640             


Phe Tyr  Gly Ser Phe His Lys  Val His Ile Val Val  Thr Ser Lys 
    2645                 2650                 2655             


Ser Val  Lys Ile Tyr Ile Asp  Cys Tyr Glu Ile Ile  Glu Lys Asp 
    2660                 2665                 2670             


Ile Lys  Glu Ala Gly Asn Ile  Thr Thr Asp Gly Tyr  Glu Ile Leu 
    2675                 2680                 2685             


Gly Lys  Leu Leu Lys Gly Glu  Arg Lys Ser Ala Ala  Phe Gln Ile 
    2690                 2695                 2700             


Gln Ser  Phe Asp Ile Val Cys  Ser Pro Val Trp Thr  Ser Arg Asp 
    2705                 2710                 2715             


Arg Cys  Cys Asp Ile Pro Ser  Arg Arg Asp Glu Gly  Lys Cys Pro 
    2720                 2725                 2730             


Ala Phe  Pro Asn Ser Cys Thr  Cys Thr Gln Asp Ser  Val Gly Pro 
    2735                 2740                 2745             


Pro Gly  Pro Pro Gly Pro Ala  Gly Gly Pro Gly Ala  Lys Gly Pro 
    2750                 2755                 2760             


Arg Gly  Glu Arg Gly Ile Ser  Gly Ala Ile Gly Pro  Pro Gly Pro 
    2765                 2770                 2775             


Arg Gly  Asp Ile Gly Pro Pro  Gly Pro Gln Gly Pro  Pro Gly Pro 
    2780                 2785                 2790             


Gln Gly  Pro Asn Gly Leu Ser  Ile Pro Gly Glu Gln  Gly Arg Gln 
    2795                 2800                 2805             


Gly Met  Lys Gly Asp Ala Gly  Glu Pro Gly Leu Pro  Gly Arg Thr 
    2810                 2815                 2820             


Gly Thr  Pro Gly Leu Pro Gly  Pro Pro Gly Pro Met  Gly Pro Pro 
    2825                 2830                 2835             


Gly Asp  Arg Gly Phe Thr Gly  Lys Asp Gly Ala Met  Gly Pro Arg 
    2840                 2845                 2850             


Gly Pro  Pro Gly Pro Pro Gly  Ser Pro Gly Ser Pro  Gly Val Thr 
    2855                 2860                 2865             


Gly Pro  Ser Gly Lys Pro Gly  Lys Pro Gly Asp His  Gly Arg Pro 
    2870                 2875                 2880             


Gly Pro  Ser Gly Leu Lys Gly  Glu Lys Gly Asp Arg  Gly Asp Ile 
    2885                 2890                 2895             


Ala Ser  Gln Asn Met Met Arg  Ala Val Ala Arg Gln  Val Cys Glu 
    2900                 2905                 2910             


Gln Leu  Ile Ser Gly Gln Met  Asn Arg Phe Asn Gln  Met Leu Asn 
    2915                 2920                 2925             


Gln Ile  Pro Asn Asp Tyr Gln  Ser Ser Arg Asn Gln  Pro Gly Pro 
    2930                 2935                 2940             


Pro Gly  Pro Pro Gly Pro Pro  Gly Ser Ala Gly Ala  Arg Gly Glu 
    2945                 2950                 2955             


Pro Gly  Pro Gly Gly Arg Pro  Gly Phe Pro Gly Thr  Pro Gly Met 
    2960                 2965                 2970             


Gln Gly  Pro Pro Gly Glu Arg  Gly Leu Pro Gly Glu  Lys Gly Glu 
    2975                 2980                 2985             


Arg Gly  Thr Gly Ser Ser Gly  Pro Arg Gly Leu Pro  Gly Pro Pro 
    2990                 2995                 3000             


Gly Pro  Gln Gly Glu Ser Arg  Thr Gly Pro Pro Gly  Ser Thr Gly 
    3005                 3010                 3015             


Ser Arg  Gly Pro Pro Gly Pro  Pro Gly Arg Pro Gly  Asn Ser Gly 
    3020                 3025                 3030             


Ile Arg  Gly Pro Pro Gly Pro  Pro Gly Tyr Cys Asp  Ser Ser Gln 
    3035                 3040                 3045             


Cys Ala  Ser Ile Pro Tyr Asn  Gly Gln Gly Tyr Pro  Gly Ser Gly 
    3050                 3055                 3060             


<210>  3226
<211>  3062
<212>  PRT
<213>  Homo Sapiens

<400>  3226

Met Arg Ser Arg Leu Pro Pro Ala Leu Ala Ala Leu Gly Ala Ala Leu 
1               5                   10                  15      


Leu Leu Ser Ser Ile Glu Ala Glu Val Asp Pro Pro Ser Asp Leu Asn 
            20                  25                  30          


Phe Lys Ile Ile Asp Glu Asn Thr Val His Met Ser Trp Ala Lys Pro 
        35                  40                  45              


Val Asp Pro Ile Val Gly Tyr Arg Ile Thr Val Asp Pro Thr Thr Asp 
    50                  55                  60                  


Gly Pro Thr Lys Glu Phe Thr Leu Ser Ala Ser Thr Thr Glu Thr Leu 
65                  70                  75                  80  


Leu Ser Glu Leu Val Pro Glu Thr Glu Tyr Val Val Thr Ile Thr Ser 
                85                  90                  95      


Tyr Asp Glu Val Glu Glu Ser Val Pro Val Ile Gly Gln Leu Thr Ile 
            100                 105                 110         


Gln Thr Gly Ser Ser Thr Lys Pro Val Glu Lys Lys Pro Gly Lys Thr 
        115                 120                 125             


Glu Ile Gln Lys Cys Ser Val Ser Ala Trp Thr Asp Leu Val Phe Leu 
    130                 135                 140                 


Val Asp Gly Ser Trp Ser Val Gly Arg Asn Asn Phe Lys Tyr Ile Leu 
145                 150                 155                 160 


Asp Phe Ile Ala Ala Leu Val Ser Ala Phe Asp Ile Gly Glu Glu Lys 
                165                 170                 175     


Thr Arg Val Gly Val Val Gln Tyr Ser Ser Asp Thr Arg Thr Glu Phe 
            180                 185                 190         


Asn Leu Asn Gln Tyr Tyr Gln Arg Asp Glu Leu Leu Ala Ala Ile Lys 
        195                 200                 205             


Lys Ile Pro Tyr Lys Gly Gly Asn Thr Met Thr Gly Asp Ala Ile Asp 
    210                 215                 220                 


Tyr Leu Val Lys Asn Thr Phe Thr Glu Ser Ala Gly Ala Arg Val Gly 
225                 230                 235                 240 


Phe Pro Lys Val Ala Ile Ile Ile Thr Asp Gly Lys Ser Gln Asp Glu 
                245                 250                 255     


Val Glu Ile Pro Ala Arg Glu Leu Arg Asn Val Gly Val Glu Val Phe 
            260                 265                 270         


Ser Leu Gly Ile Lys Ala Ala Asp Ala Lys Glu Leu Lys Gln Ile Ala 
        275                 280                 285             


Ser Thr Pro Ser Leu Asn His Val Phe Asn Val Ala Asn Phe Asp Ala 
    290                 295                 300                 


Ile Val Asp Ile Gln Asn Glu Ile Ile Ser Gln Val Cys Ser Gly Val 
305                 310                 315                 320 


Asp Glu Gln Leu Gly Glu Leu Val Ser Gly Glu Glu Val Val Glu Pro 
                325                 330                 335     


Pro Ser Asn Leu Ile Ala Met Glu Val Ser Ser Lys Tyr Val Lys Leu 
            340                 345                 350         


Asn Trp Asn Pro Ser Pro Ser Pro Val Thr Gly Tyr Lys Val Ile Leu 
        355                 360                 365             


Thr Pro Met Thr Ala Gly Ser Arg Gln His Ala Leu Ser Val Gly Pro 
    370                 375                 380                 


Gln Thr Thr Thr Leu Ser Val Arg Asp Leu Ser Ala Asp Thr Glu Tyr 
385                 390                 395                 400 


Gln Ile Ser Val Ser Ala Met Lys Gly Met Thr Ser Ser Glu Pro Ile 
                405                 410                 415     


Ser Ile Met Glu Lys Thr Gln Pro Met Lys Val Gln Val Glu Cys Ser 
            420                 425                 430         


Arg Gly Val Asp Ile Lys Ala Asp Ile Val Phe Leu Val Asp Gly Ser 
        435                 440                 445             


Tyr Ser Ile Gly Ile Ala Asn Phe Val Lys Val Arg Ala Phe Leu Glu 
    450                 455                 460                 


Val Leu Val Lys Ser Phe Glu Ile Ser Pro Asn Arg Val Gln Ile Ser 
465                 470                 475                 480 


Leu Val Gln Tyr Ser Arg Asp Pro His Thr Glu Phe Thr Leu Lys Lys 
                485                 490                 495     


Phe Thr Lys Val Glu Asp Ile Ile Glu Ala Ile Asn Thr Phe Pro Tyr 
            500                 505                 510         


Arg Gly Gly Ser Thr Asn Thr Gly Lys Ala Met Thr Tyr Val Arg Glu 
        515                 520                 525             


Lys Ile Phe Val Pro Ser Lys Gly Ser Arg Ser Asn Val Pro Lys Val 
    530                 535                 540                 


Met Ile Leu Ile Thr Asp Gly Lys Ser Ser Asp Ala Phe Arg Asp Pro 
545                 550                 555                 560 


Ala Ile Lys Leu Arg Asn Ser Asp Val Glu Ile Phe Ala Val Gly Val 
                565                 570                 575     


Lys Asp Ala Val Arg Ser Glu Leu Glu Ala Ile Ala Ser Pro Pro Ala 
            580                 585                 590         


Glu Thr His Val Phe Thr Val Glu Asp Phe Asp Ala Phe Gln Arg Ile 
        595                 600                 605             


Ser Phe Glu Leu Thr Gln Ser Ile Cys Leu Arg Ile Glu Gln Glu Leu 
    610                 615                 620                 


Ala Ala Ile Lys Lys Lys Ala Tyr Val Pro Pro Lys Asp Leu Ser Phe 
625                 630                 635                 640 


Ser Glu Val Thr Ser Tyr Gly Phe Lys Thr Asn Trp Ser Pro Ala Gly 
                645                 650                 655     


Glu Asn Val Phe Ser Tyr His Ile Thr Tyr Lys Glu Ala Ala Gly Asp 
            660                 665                 670         


Asp Glu Val Thr Val Val Glu Pro Ala Ser Ser Thr Ser Val Val Leu 
        675                 680                 685             


Ser Ser Leu Lys Pro Glu Thr Leu Tyr Leu Val Asn Val Thr Ala Glu 
    690                 695                 700                 


Tyr Glu Asp Gly Phe Ser Ile Pro Leu Ala Gly Glu Glu Thr Thr Glu 
705                 710                 715                 720 


Glu Val Lys Gly Ala Pro Arg Asn Leu Lys Val Thr Asp Glu Thr Thr 
                725                 730                 735     


Asp Ser Phe Lys Ile Thr Trp Thr Gln Ala Pro Gly Arg Val Leu Arg 
            740                 745                 750         


Tyr Arg Ile Ile Tyr Arg Pro Val Ala Gly Gly Glu Ser Arg Glu Val 
        755                 760                 765             


Thr Thr Pro Pro Asn Gln Arg Arg Arg Thr Leu Glu Asn Leu Ile Pro 
    770                 775                 780                 


Asp Thr Lys Tyr Glu Val Ser Val Ile Pro Glu Tyr Phe Ser Gly Pro 
785                 790                 795                 800 


Gly Thr Pro Leu Thr Gly Asn Ala Ala Thr Glu Glu Val Arg Gly Asn 
                805                 810                 815     


Pro Arg Asp Leu Arg Val Ser Asp Pro Thr Thr Ser Thr Met Lys Leu 
            820                 825                 830         


Ser Trp Ser Gly Ala Pro Gly Lys Val Lys Gln Tyr Leu Val Thr Tyr 
        835                 840                 845             


Thr Pro Val Ala Gly Gly Glu Thr Gln Glu Val Thr Val Arg Gly Asp 
    850                 855                 860                 


Thr Thr Asn Thr Val Leu Gln Gly Leu Lys Glu Gly Thr Gln Tyr Ala 
865                 870                 875                 880 


Leu Ser Val Thr Ala Leu Tyr Ala Ser Gly Ala Gly Asp Ala Leu Phe 
                885                 890                 895     


Gly Glu Gly Thr Thr Leu Glu Glu Arg Gly Ser Pro Gln Asp Leu Val 
            900                 905                 910         


Thr Lys Asp Ile Thr Asp Thr Ser Ile Gly Ala Tyr Trp Thr Ser Ala 
        915                 920                 925             


Pro Gly Met Val Arg Gly Tyr Arg Val Ser Trp Lys Ser Leu Tyr Asp 
    930                 935                 940                 


Asp Val Asp Thr Gly Glu Lys Asn Leu Pro Glu Asp Ala Ile His Thr 
945                 950                 955                 960 


Met Ile Glu Asn Leu Gln Pro Glu Thr Lys Tyr Arg Ile Ser Val Phe 
                965                 970                 975     


Ala Thr Tyr Ser Ser Gly Glu Gly Glu Pro Leu Thr Gly Asp Ala Thr 
            980                 985                 990         


Thr Glu Leu Ser Gln Asp Ser Lys  Thr Leu Lys Val Asp  Glu Glu Thr 
        995                 1000                 1005             


Glu Asn  Thr Met Arg Val Thr  Trp Lys Pro Ala Pro  Gly Lys Val 
    1010                 1015                 1020             


Val Asn  Tyr Arg Val Val Tyr  Arg Pro His Gly Arg  Gly Lys Gln 
    1025                 1030                 1035             


Met Val  Ala Lys Val Pro Pro  Thr Val Thr Ser Thr  Val Leu Lys 
    1040                 1045                 1050             


Arg Leu  Gln Pro Gln Thr Thr  Tyr Asp Ile Thr Val  Leu Pro Ile 
    1055                 1060                 1065             


Tyr Lys  Met Gly Glu Gly Lys  Leu Arg Gln Gly Ser  Gly Thr Thr 
    1070                 1075                 1080             


Ala Ser  Arg Phe Lys Ser Pro  Arg Asn Leu Lys Thr  Ser Asp Pro 
    1085                 1090                 1095             


Thr Met  Ser Ser Phe Arg Val  Thr Trp Glu Pro Ala  Pro Gly Glu 
    1100                 1105                 1110             


Val Lys  Gly Tyr Lys Val Thr  Phe His Pro Thr Gly  Asp Asp Arg 
    1115                 1120                 1125             


Arg Leu  Gly Glu Leu Val Val  Gly Pro Tyr Asp Asn  Thr Val Val 
    1130                 1135                 1140             


Leu Glu  Glu Leu Arg Ala Gly  Thr Thr Tyr Lys Val  Asn Val Phe 
    1145                 1150                 1155             


Gly Met  Phe Asp Gly Gly Glu  Ser Ser Pro Leu Val  Gly Gln Glu 
    1160                 1165                 1170             


Met Thr  Thr Leu Ser Asp Thr  Thr Val Met Pro Ile  Leu Ser Ser 
    1175                 1180                 1185             


Gly Met  Glu Cys Leu Thr Arg  Ala Glu Ala Asp Ile  Val Leu Leu 
    1190                 1195                 1200             


Val Asp  Gly Ser Trp Ser Ile  Gly Arg Ala Asn Phe  Arg Thr Val 
    1205                 1210                 1215             


Arg Ser  Phe Ile Ser Arg Ile  Val Glu Val Phe Asp  Ile Gly Pro 
    1220                 1225                 1230             


Lys Arg  Val Gln Ile Ala Leu  Ala Gln Tyr Ser Gly  Asp Pro Arg 
    1235                 1240                 1245             


Thr Glu  Trp Gln Leu Asn Ala  His Arg Asp Lys Lys  Ser Leu Leu 
    1250                 1255                 1260             


Gln Ala  Val Ala Asn Leu Pro  Tyr Lys Gly Gly Asn  Thr Leu Thr 
    1265                 1270                 1275             


Gly Met  Ala Leu Asn Phe Ile  Arg Gln Gln Asn Phe  Arg Thr Gln 
    1280                 1285                 1290             


Ala Gly  Met Arg Pro Arg Ala  Arg Lys Ile Gly Val  Leu Ile Thr 
    1295                 1300                 1305             


Asp Gly  Lys Ser Gln Asp Asp  Val Glu Ala Pro Ser  Lys Lys Leu 
    1310                 1315                 1320             


Lys Asp  Glu Gly Val Glu Leu  Phe Ala Ile Gly Ile  Lys Asn Ala 
    1325                 1330                 1335             


Asp Glu  Val Glu Leu Lys Met  Ile Ala Thr Asp Pro  Asp Asp Thr 
    1340                 1345                 1350             


His Ala  Tyr Asn Val Ala Asp  Phe Glu Ser Leu Ser  Arg Ile Val 
    1355                 1360                 1365             


Asp Asp  Leu Thr Ile Asn Leu  Cys Asn Ser Val Lys  Gly Pro Gly 
    1370                 1375                 1380             


Asp Leu  Glu Ala Pro Ser Asn  Leu Val Ile Ser Glu  Arg Thr His 
    1385                 1390                 1395             


Arg Ser  Phe Arg Val Ser Trp  Thr Pro Pro Ser Asp  Ser Val Asp 
    1400                 1405                 1410             


Arg Tyr  Lys Val Glu Tyr Tyr  Pro Val Ser Gly Gly  Lys Arg Gln 
    1415                 1420                 1425             


Glu Phe  Tyr Val Ser Arg Met  Glu Thr Ser Thr Val  Leu Lys Asp 
    1430                 1435                 1440             


Leu Lys  Pro Glu Thr Glu Tyr  Val Val Asn Val Tyr  Ser Val Val 
    1445                 1450                 1455             


Glu Asp  Glu Tyr Ser Glu Pro  Leu Lys Gly Thr Glu  Lys Thr Leu 
    1460                 1465                 1470             


Pro Val  Pro Val Val Ser Leu  Asn Ile Tyr Asp Val  Gly Pro Thr 
    1475                 1480                 1485             


Thr Met  His Val Gln Trp Gln  Pro Val Gly Gly Ala  Thr Gly Tyr 
    1490                 1495                 1500             


Ile Leu  Ser Tyr Lys Pro Val  Lys Asp Thr Glu Pro  Thr Arg Pro 
    1505                 1510                 1515             


Lys Glu  Val Arg Leu Gly Pro  Thr Val Asn Asp Met  Gln Leu Thr 
    1520                 1525                 1530             


Asp Leu  Val Pro Asn Thr Glu  Tyr Ala Val Thr Val  Gln Ala Val 
    1535                 1540                 1545             


Leu His  Asp Leu Thr Ser Glu  Pro Val Thr Val Arg  Glu Val Thr 
    1550                 1555                 1560             


Leu Pro  Leu Pro Arg Pro Gln  Asp Leu Lys Leu Arg  Asp Val Thr 
    1565                 1570                 1575             


His Ser  Thr Met Asn Val Phe  Trp Glu Pro Val Pro  Gly Lys Val 
    1580                 1585                 1590             


Arg Lys  Tyr Ile Val Arg Tyr  Lys Thr Pro Glu Glu  Asp Val Lys 
    1595                 1600                 1605             


Glu Val  Glu Val Asp Arg Ser  Glu Thr Ser Thr Ser  Leu Lys Asp 
    1610                 1615                 1620             


Leu Phe  Ser Gln Thr Leu Tyr  Thr Val Ser Val Ser  Ala Val His 
    1625                 1630                 1635             


Asp Glu  Gly Glu Ser Pro Pro  Val Thr Ala Gln Glu  Thr Thr Arg 
    1640                 1645                 1650             


Pro Val  Pro Ala Pro Thr Asn  Leu Lys Ile Thr Glu  Val Thr Ser 
    1655                 1660                 1665             


Glu Gly  Phe Arg Gly Thr Trp  Asp His Gly Ala Ser  Asp Val Ser 
    1670                 1675                 1680             


Leu Tyr  Arg Ile Thr Trp Ala  Pro Phe Gly Ser Ser  Asp Lys Met 
    1685                 1690                 1695             


Glu Thr  Ile Leu Asn Gly Asp  Glu Asn Thr Leu Val  Phe Glu Asn 
    1700                 1705                 1710             


Leu Asn  Pro Asn Thr Ile Tyr  Glu Val Ser Ile Thr  Ala Ile Tyr 
    1715                 1720                 1725             


Pro Asp  Glu Ser Glu Ser Asp  Asp Leu Ile Gly Ser  Glu Arg Thr 
    1730                 1735                 1740             


Leu Pro  Ile Leu Thr Thr Gln  Ala Pro Lys Ser Gly  Pro Arg Asn 
    1745                 1750                 1755             


Leu Gln  Val Tyr Asn Ala Thr  Ser Asn Ser Leu Thr  Val Lys Trp 
    1760                 1765                 1770             


Asp Pro  Ala Ser Gly Arg Val  Gln Lys Tyr Arg Ile  Thr Tyr Gln 
    1775                 1780                 1785             


Pro Ser  Thr Gly Glu Gly Asn  Glu Gln Thr Thr Thr  Ile Gly Gly 
    1790                 1795                 1800             


Arg Gln  Asn Ser Val Val Leu  Gln Lys Leu Lys Pro  Asp Thr Pro 
    1805                 1810                 1815             


Tyr Thr  Ile Thr Val Ser Ser  Leu Tyr Pro Asp Gly  Glu Gly Gly 
    1820                 1825                 1830             


Arg Met  Thr Gly Arg Gly Lys  Thr Lys Pro Leu Asn  Thr Val Arg 
    1835                 1840                 1845             


Asn Leu  Arg Val Tyr Asp Pro  Ser Thr Ser Thr Leu  Asn Val Arg 
    1850                 1855                 1860             


Trp Asp  His Ala Glu Gly Asn  Pro Arg Gln Tyr Lys  Leu Phe Tyr 
    1865                 1870                 1875             


Ala Pro  Ala Ala Gly Gly Pro  Glu Glu Leu Val Pro  Ile Pro Gly 
    1880                 1885                 1890             


Asn Thr  Asn Tyr Ala Ile Leu  Arg Asn Leu Gln Pro  Asp Thr Ser 
    1895                 1900                 1905             


Tyr Thr  Val Thr Val Val Pro  Val Tyr Thr Glu Gly  Asp Gly Gly 
    1910                 1915                 1920             


Arg Thr  Ser Asp Thr Gly Arg  Thr Leu Met Arg Gly  Leu Ala Arg 
    1925                 1930                 1935             


Asn Val  Gln Val Tyr Asn Pro  Thr Pro Asn Ser Leu  Asp Val Arg 
    1940                 1945                 1950             


Trp Asp  Pro Ala Pro Gly Pro  Val Leu Gln Tyr Arg  Val Val Tyr 
    1955                 1960                 1965             


Ser Pro  Val Asp Gly Thr Arg  Pro Ser Glu Ser Ile  Val Val Pro 
    1970                 1975                 1980             


Gly Asn  Thr Arg Met Val His  Leu Glu Arg Leu Ile  Pro Asp Thr 
    1985                 1990                 1995             


Leu Tyr  Ser Val Asn Leu Val  Ala Leu Tyr Ser Asp  Gly Glu Gly 
    2000                 2005                 2010             


Asn Pro  Ser Pro Ala Gln Gly  Arg Thr Leu Pro Arg  Ser Gly Pro 
    2015                 2020                 2025             


Arg Asn  Leu Arg Val Phe Gly  Glu Thr Thr Asn Ser  Leu Ser Val 
    2030                 2035                 2040             


Ala Trp  Asp His Ala Asp Gly  Pro Val Gln Gln Tyr  Arg Ile Ile 
    2045                 2050                 2055             


Tyr Ser  Pro Thr Val Gly Asp  Pro Ile Asp Glu Tyr  Thr Thr Val 
    2060                 2065                 2070             


Pro Gly  Arg Arg Asn Asn Val  Ile Leu Gln Pro Leu  Gln Pro Asp 
    2075                 2080                 2085             


Thr Pro  Tyr Lys Ile Thr Val  Ile Ala Val Tyr Glu  Asp Gly Asp 
    2090                 2095                 2100             


Gly Gly  His Leu Thr Gly Asn  Gly Arg Thr Val Gly  Leu Leu Pro 
    2105                 2110                 2115             


Pro Gln  Asn Ile His Ile Ser  Asp Glu Trp Tyr Thr  Arg Phe Arg 
    2120                 2125                 2130             


Val Ser  Trp Asp Pro Ser Pro  Ser Pro Val Leu Gly  Tyr Lys Ile 
    2135                 2140                 2145             


Val Tyr  Lys Pro Val Gly Ser  Asn Glu Pro Met Glu  Ala Phe Val 
    2150                 2155                 2160             


Gly Glu  Met Thr Ser Tyr Thr  Leu His Asn Leu Asn  Pro Ser Thr 
    2165                 2170                 2175             


Thr Tyr  Asp Val Asn Val Tyr  Ala Gln Tyr Asp Ser  Gly Leu Ser 
    2180                 2185                 2190             


Val Pro  Leu Thr Asp Gln Gly  Thr Thr Leu Tyr Leu  Asn Val Thr 
    2195                 2200                 2205             


Asp Leu  Lys Thr Tyr Gln Ile  Gly Trp Asp Thr Phe  Cys Val Lys 
    2210                 2215                 2220             


Trp Ser  Pro His Arg Ala Ala  Thr Ser Tyr Arg Leu  Lys Leu Ser 
    2225                 2230                 2235             


Pro Ala  Asp Gly Thr Arg Gly  Gln Glu Ile Thr Val  Arg Gly Ser 
    2240                 2245                 2250             


Glu Thr  Ser His Cys Phe Thr  Gly Leu Ser Pro Asp  Thr Asp Tyr 
    2255                 2260                 2265             


Gly Val  Thr Val Phe Val Gln  Thr Pro Asn Leu Glu  Gly Pro Gly 
    2270                 2275                 2280             


Val Ser  Val Lys Glu His Thr  Thr Val Lys Pro Thr  Glu Ala Pro 
    2285                 2290                 2295             


Thr Glu  Pro Pro Thr Pro Pro  Pro Pro Pro Thr Ile  Pro Pro Ala 
    2300                 2305                 2310             


Arg Asp  Val Cys Lys Gly Ala  Lys Ala Asp Ile Val  Phe Leu Thr 
    2315                 2320                 2325             


Asp Ala  Ser Trp Ser Ile Gly  Asp Asp Asn Phe Asn  Lys Val Val 
    2330                 2335                 2340             


Lys Phe  Ile Phe Asn Thr Val  Gly Gly Phe Asp Glu  Ile Ser Pro 
    2345                 2350                 2355             


Ala Gly  Ile Gln Val Ser Phe  Val Gln Tyr Ser Asp  Glu Val Lys 
    2360                 2365                 2370             


Ser Glu  Phe Lys Leu Asn Thr  Tyr Asn Asp Lys Ala  Leu Ala Leu 
    2375                 2380                 2385             


Gly Ala  Leu Gln Asn Ile Arg  Tyr Arg Gly Gly Asn  Thr Arg Thr 
    2390                 2395                 2400             


Gly Lys  Ala Leu Thr Phe Ile  Lys Glu Lys Val Leu  Thr Trp Glu 
    2405                 2410                 2415             


Ser Gly  Met Arg Lys Asn Val  Pro Lys Val Leu Val  Val Val Thr 
    2420                 2425                 2430             


Asp Gly  Arg Ser Gln Asp Glu  Val Lys Lys Ala Ala  Leu Val Ile 
    2435                 2440                 2445             


Gln Gln  Ser Gly Phe Ser Val  Phe Val Val Gly Val  Ala Asp Val 
    2450                 2455                 2460             


Asp Tyr  Asn Glu Leu Ala Asn  Ile Ala Ser Lys Pro  Ser Glu Arg 
    2465                 2470                 2475             


His Val  Phe Ile Val Asp Asp  Phe Glu Ser Phe Glu  Lys Ile Glu 
    2480                 2485                 2490             


Asp Asn  Leu Ile Thr Phe Val  Cys Glu Thr Ala Thr  Ser Ser Cys 
    2495                 2500                 2505             


Pro Leu  Ile Tyr Leu Asp Gly  Tyr Thr Ser Pro Gly  Phe Lys Met 
    2510                 2515                 2520             


Leu Glu  Ala Tyr Asn Leu Thr  Glu Lys Asn Phe Ala  Ser Val Gln 
    2525                 2530                 2535             


Gly Val  Ser Leu Glu Ser Gly  Ser Phe Pro Ser Tyr  Ser Ala Tyr 
    2540                 2545                 2550             


Arg Ile  Gln Lys Asn Ala Phe  Val Asn Gln Pro Thr  Ala Asp Leu 
    2555                 2560                 2565             


His Pro  Asn Gly Leu Pro Pro  Ser Tyr Thr Ile Ile  Leu Leu Phe 
    2570                 2575                 2580             


Arg Leu  Leu Pro Glu Thr Pro  Ser Asp Pro Phe Ala  Ile Trp Gln 
    2585                 2590                 2595             


Ile Thr  Asp Arg Asp Tyr Lys  Pro Gln Val Gly Val  Ile Ala Asp 
    2600                 2605                 2610             


Pro Ser  Ser Lys Thr Leu Ser  Phe Phe Asn Lys Asp  Thr Arg Gly 
    2615                 2620                 2625             


Glu Val  Gln Thr Val Thr Phe  Asp Thr Glu Glu Val  Lys Thr Leu 
    2630                 2635                 2640             


Phe Tyr  Gly Ser Phe His Lys  Val His Ile Val Val  Thr Ser Lys 
    2645                 2650                 2655             


Ser Val  Lys Ile Tyr Ile Asp  Cys Tyr Glu Ile Ile  Glu Lys Asp 
    2660                 2665                 2670             


Ile Lys  Glu Ala Gly Asn Ile  Thr Thr Asp Gly Tyr  Glu Ile Leu 
    2675                 2680                 2685             


Gly Lys  Leu Leu Lys Gly Glu  Arg Lys Ser Ala Ala  Phe Gln Ile 
    2690                 2695                 2700             


Gln Ser  Phe Asp Ile Val Cys  Ser Pro Val Trp Thr  Ser Arg Asp 
    2705                 2710                 2715             


Arg Cys  Cys Asp Ile Pro Ser  Arg Arg Asp Glu Gly  Lys Cys Pro 
    2720                 2725                 2730             


Ala Phe  Pro Asn Ser Cys Thr  Cys Thr Gln Asp Ser  Val Gly Pro 
    2735                 2740                 2745             


Pro Gly  Pro Pro Gly Pro Ala  Gly Gly Pro Gly Ala  Lys Gly Pro 
    2750                 2755                 2760             


Arg Gly  Glu Arg Gly Ile Ser  Gly Ala Ile Gly Pro  Pro Gly Pro 
    2765                 2770                 2775             


Arg Gly  Asp Ile Gly Pro Pro  Gly Pro Gln Gly Pro  Pro Gly Pro 
    2780                 2785                 2790             


Gln Gly  Pro Asn Gly Leu Ser  Ile Pro Gly Glu Gln  Gly Arg Gln 
    2795                 2800                 2805             


Gly Met  Lys Gly Asp Ala Gly  Glu Pro Gly Leu Pro  Gly Arg Thr 
    2810                 2815                 2820             


Gly Thr  Pro Gly Leu Pro Gly  Pro Pro Gly Pro Met  Gly Pro Pro 
    2825                 2830                 2835             


Gly Asp  Arg Gly Phe Thr Gly  Lys Asp Gly Ala Met  Gly Pro Arg 
    2840                 2845                 2850             


Gly Pro  Pro Gly Pro Gly Ser  Pro Gly Val Thr Gly  Pro Ser Gly 
    2855                 2860                 2865             


Lys Pro  Gly Lys Pro Gly Asp  His Gly Arg Pro Gly  Pro Ser Gly 
    2870                 2875                 2880             


Leu Lys  Gly Glu Lys Gly Asp  Arg Gly Asp Ile Ala  Ser Gln Asn 
    2885                 2890                 2895             


Met Met  Arg Ala Val Ala Arg  Gln Val Cys Glu Gln  Leu Ile Ser 
    2900                 2905                 2910             


Gly Gln  Met Asn Arg Phe Asn  Gln Met Leu Asn Gln  Ile Pro Asn 
    2915                 2920                 2925             


Asp Tyr  Gln Ser Ser Arg Asn  Gln Pro Gly Pro Pro  Gly Pro Pro 
    2930                 2935                 2940             


Gly Pro  Pro Gly Ser Ala Gly  Ala Arg Gly Glu Pro  Gly Pro Gly 
    2945                 2950                 2955             


Gly Arg  Pro Gly Phe Pro Gly  Thr Pro Gly Met Gln  Gly Pro Pro 
    2960                 2965                 2970             


Gly Glu  Arg Gly Leu Pro Gly  Glu Lys Gly Glu Arg  Gly Thr Gly 
    2975                 2980                 2985             


Ser Ser  Gly Pro Arg Gly Leu  Pro Gly Pro Pro Gly  Pro Gln Gly 
    2990                 2995                 3000             


Glu Ser  Arg Thr Gly Pro Pro  Gly Ser Thr Gly Ser  Arg Gly Pro 
    3005                 3010                 3015             


Pro Gly  Pro Pro Gly Arg Pro  Gly Asn Ser Gly Ile  Arg Gly Pro 
    3020                 3025                 3030             


Pro Gly  Pro Pro Gly Tyr Cys  Asp Ser Ser Gln Cys  Ala Ser Ile 
    3035                 3040                 3045             


Pro Tyr  Asn Gly Gln Gly Tyr  Pro Gly Thr Leu Leu  Pro Leu 
    3050                 3055                 3060         


<210>  3227
<211>  2987
<212>  PRT
<213>  Homo Sapiens

<400>  3227

Met Arg Ser Arg Leu Pro Pro Ala Leu Ala Ala Leu Gly Ala Ala Leu 
1               5                   10                  15      


Leu Leu Ser Ser Ile Glu Ala Glu Val Asp Pro Pro Ser Asp Leu Asn 
            20                  25                  30          


Phe Lys Ile Ile Asp Glu Asn Thr Val His Met Ser Trp Ala Lys Pro 
        35                  40                  45              


Val Asp Pro Ile Val Gly Tyr Arg Ile Thr Val Asp Pro Thr Thr Asp 
    50                  55                  60                  


Gly Pro Thr Lys Glu Phe Thr Leu Ser Ala Ser Thr Thr Glu Thr Leu 
65                  70                  75                  80  


Leu Ser Glu Leu Val Pro Glu Thr Glu Tyr Val Val Thr Ile Thr Ser 
                85                  90                  95      


Tyr Asp Glu Val Glu Glu Ser Val Pro Val Ile Gly Gln Leu Thr Ile 
            100                 105                 110         


Gln Thr Gly Ser Ser Thr Lys Pro Val Glu Lys Lys Pro Gly Lys Thr 
        115                 120                 125             


Glu Ile Gln Lys Cys Ser Val Ser Ala Trp Thr Asp Leu Val Phe Leu 
    130                 135                 140                 


Val Asp Gly Ser Trp Ser Val Gly Arg Asn Asn Phe Lys Tyr Ile Leu 
145                 150                 155                 160 


Asp Phe Ile Ala Ala Leu Val Ser Ala Phe Asp Ile Gly Glu Glu Lys 
                165                 170                 175     


Thr Arg Val Gly Val Val Gln Tyr Ser Ser Asp Thr Arg Thr Glu Phe 
            180                 185                 190         


Asn Leu Asn Gln Tyr Tyr Gln Arg Asp Glu Leu Leu Ala Ala Ile Lys 
        195                 200                 205             


Lys Ile Pro Tyr Lys Gly Gly Asn Thr Met Thr Gly Asp Ala Ile Asp 
    210                 215                 220                 


Tyr Leu Val Lys Asn Thr Phe Thr Glu Ser Ala Gly Ala Arg Val Gly 
225                 230                 235                 240 


Phe Pro Lys Val Ala Ile Ile Ile Thr Asp Gly Lys Ser Gln Asp Glu 
                245                 250                 255     


Val Glu Ile Pro Ala Arg Glu Leu Arg Asn Val Gly Val Glu Val Phe 
            260                 265                 270         


Ser Leu Gly Ile Lys Ala Ala Asp Ala Lys Glu Leu Lys Gln Ile Ala 
        275                 280                 285             


Ser Thr Pro Ser Leu Asn His Val Phe Asn Val Ala Asn Phe Asp Ala 
    290                 295                 300                 


Ile Val Asp Ile Gln Asn Glu Ile Ile Ser Gln Val Cys Ser Gly Val 
305                 310                 315                 320 


Asp Glu Gln Leu Gly Glu Leu Val Ser Gly Glu Glu Val Val Glu Pro 
                325                 330                 335     


Pro Ser Asn Leu Ile Ala Met Glu Val Ser Ser Lys Tyr Val Lys Leu 
            340                 345                 350         


Asn Trp Asn Pro Ser Pro Ser Pro Val Thr Gly Tyr Lys Val Ile Leu 
        355                 360                 365             


Thr Pro Met Thr Ala Gly Ser Arg Gln His Ala Leu Ser Val Gly Pro 
    370                 375                 380                 


Gln Thr Thr Thr Leu Ser Val Arg Asp Leu Ser Ala Asp Thr Glu Tyr 
385                 390                 395                 400 


Gln Ile Ser Val Ser Ala Met Lys Gly Met Thr Ser Ser Glu Pro Ile 
                405                 410                 415     


Ser Ile Met Glu Lys Thr Gln Pro Met Lys Val Gln Val Glu Cys Ser 
            420                 425                 430         


Arg Gly Val Asp Ile Lys Ala Asp Ile Val Phe Leu Val Asp Gly Ser 
        435                 440                 445             


Tyr Ser Ile Gly Ile Ala Asn Phe Val Lys Val Arg Ala Phe Leu Glu 
    450                 455                 460                 


Val Leu Val Lys Ser Phe Glu Ile Ser Pro Asn Arg Val Gln Ile Ser 
465                 470                 475                 480 


Leu Val Gln Tyr Ser Arg Asp Pro His Thr Glu Phe Thr Leu Lys Lys 
                485                 490                 495     


Phe Thr Lys Val Glu Asp Ile Ile Glu Ala Ile Asn Thr Phe Pro Tyr 
            500                 505                 510         


Arg Gly Gly Ser Thr Asn Thr Gly Lys Ala Met Thr Tyr Val Arg Glu 
        515                 520                 525             


Lys Ile Phe Val Pro Ser Lys Gly Ser Arg Ser Asn Val Pro Lys Val 
    530                 535                 540                 


Met Ile Leu Ile Thr Asp Gly Lys Ser Ser Asp Ala Phe Arg Asp Pro 
545                 550                 555                 560 


Ala Ile Lys Leu Arg Asn Ser Asp Val Glu Ile Phe Ala Val Gly Val 
                565                 570                 575     


Lys Asp Ala Val Arg Ser Glu Leu Glu Ala Ile Ala Ser Pro Pro Ala 
            580                 585                 590         


Glu Thr His Val Phe Thr Val Glu Asp Phe Asp Ala Phe Gln Arg Ile 
        595                 600                 605             


Ser Phe Glu Leu Thr Gln Ser Ile Cys Leu Arg Ile Glu Gln Glu Leu 
    610                 615                 620                 


Ala Ala Ile Lys Lys Lys Ala Tyr Val Pro Pro Lys Asp Leu Ser Phe 
625                 630                 635                 640 


Ser Glu Val Thr Ser Tyr Gly Phe Lys Thr Asn Trp Ser Pro Ala Gly 
                645                 650                 655     


Glu Asn Val Phe Ser Tyr His Ile Thr Tyr Lys Glu Ala Ala Gly Asp 
            660                 665                 670         


Asp Glu Val Thr Val Val Glu Pro Ala Ser Ser Thr Ser Val Val Leu 
        675                 680                 685             


Ser Ser Leu Lys Pro Glu Thr Leu Tyr Leu Val Asn Val Thr Ala Glu 
    690                 695                 700                 


Tyr Glu Asp Gly Phe Ser Ile Pro Leu Ala Gly Glu Glu Thr Thr Glu 
705                 710                 715                 720 


Glu Val Lys Gly Ala Pro Arg Asn Leu Lys Val Thr Asp Glu Thr Thr 
                725                 730                 735     


Asp Ser Phe Lys Ile Thr Trp Thr Gln Ala Pro Gly Arg Val Leu Arg 
            740                 745                 750         


Tyr Arg Ile Ile Tyr Arg Pro Val Ala Gly Gly Glu Ser Arg Glu Val 
        755                 760                 765             


Thr Thr Pro Pro Asn Gln Arg Arg Arg Thr Leu Glu Asn Leu Ile Pro 
    770                 775                 780                 


Asp Thr Lys Tyr Glu Val Ser Val Ile Pro Glu Tyr Phe Ser Gly Pro 
785                 790                 795                 800 


Gly Thr Pro Leu Thr Gly Asn Ala Ala Thr Glu Glu Val Arg Gly Asn 
                805                 810                 815     


Pro Arg Asp Leu Arg Val Ser Asp Pro Thr Thr Ser Thr Met Lys Leu 
            820                 825                 830         


Ser Trp Ser Gly Ala Pro Gly Lys Val Lys Gln Tyr Leu Val Thr Tyr 
        835                 840                 845             


Thr Pro Val Ala Gly Gly Glu Thr Gln Glu Val Thr Val Arg Gly Asp 
    850                 855                 860                 


Thr Thr Asn Thr Val Leu Gln Gly Leu Lys Glu Gly Thr Gln Tyr Ala 
865                 870                 875                 880 


Leu Ser Val Thr Ala Leu Tyr Ala Ser Gly Ala Gly Asp Ala Leu Phe 
                885                 890                 895     


Gly Glu Gly Thr Thr Leu Glu Glu Arg Gly Ser Pro Gln Asp Leu Val 
            900                 905                 910         


Thr Lys Asp Ile Thr Asp Thr Ser Ile Gly Ala Tyr Trp Thr Ser Ala 
        915                 920                 925             


Pro Gly Met Val Arg Gly Tyr Arg Val Ser Trp Lys Ser Leu Tyr Asp 
    930                 935                 940                 


Asp Val Asp Thr Gly Glu Lys Asn Leu Pro Glu Asp Ala Ile His Thr 
945                 950                 955                 960 


Met Ile Glu Asn Leu Gln Pro Glu Thr Lys Tyr Arg Ile Ser Val Phe 
                965                 970                 975     


Ala Thr Tyr Ser Ser Gly Glu Gly Glu Pro Leu Thr Gly Asp Ala Thr 
            980                 985                 990         


Thr Glu Leu Ser Gln Asp Ser Lys  Thr Leu Lys Val Asp  Glu Glu Thr 
        995                 1000                 1005             


Glu Asn  Thr Met Arg Val Thr  Trp Lys Pro Ala Pro  Gly Lys Val 
    1010                 1015                 1020             


Val Asn  Tyr Arg Val Val Tyr  Arg Pro His Gly Arg  Gly Lys Gln 
    1025                 1030                 1035             


Met Val  Ala Lys Val Pro Pro  Thr Val Thr Ser Thr  Val Leu Lys 
    1040                 1045                 1050             


Arg Leu  Gln Pro Gln Thr Thr  Tyr Asp Ile Thr Val  Leu Pro Ile 
    1055                 1060                 1065             


Tyr Lys  Met Gly Glu Gly Lys  Leu Arg Gln Gly Ser  Gly Thr Thr 
    1070                 1075                 1080             


Ala Ser  Arg Phe Lys Ser Pro  Arg Asn Leu Lys Thr  Ser Asp Pro 
    1085                 1090                 1095             


Thr Met  Ser Ser Phe Arg Val  Thr Trp Glu Pro Ala  Pro Gly Glu 
    1100                 1105                 1110             


Val Lys  Gly Tyr Lys Val Thr  Phe His Pro Thr Gly  Asp Asp Arg 
    1115                 1120                 1125             


Arg Leu  Gly Glu Leu Val Val  Gly Pro Tyr Asp Asn  Thr Val Val 
    1130                 1135                 1140             


Leu Glu  Glu Leu Arg Ala Gly  Thr Thr Tyr Lys Val  Asn Val Phe 
    1145                 1150                 1155             


Gly Met  Phe Asp Gly Gly Glu  Ser Ser Pro Leu Val  Gly Gln Glu 
    1160                 1165                 1170             


Met Thr  Thr Leu Ser Asp Thr  Thr Val Met Pro Ile  Leu Ser Ser 
    1175                 1180                 1185             


Gly Met  Glu Cys Leu Thr Arg  Ala Glu Ala Asp Ile  Val Leu Leu 
    1190                 1195                 1200             


Val Asp  Gly Ser Trp Ser Ile  Gly Arg Ala Asn Phe  Arg Thr Val 
    1205                 1210                 1215             


Arg Ser  Phe Ile Ser Arg Ile  Val Glu Val Phe Asp  Ile Gly Pro 
    1220                 1225                 1230             


Lys Arg  Val Gln Ile Ala Leu  Ala Gln Tyr Ser Gly  Asp Pro Arg 
    1235                 1240                 1245             


Thr Glu  Trp Gln Leu Asn Ala  His Arg Asp Lys Lys  Ser Leu Leu 
    1250                 1255                 1260             


Gln Ala  Val Ala Asn Leu Pro  Tyr Lys Gly Gly Asn  Thr Leu Thr 
    1265                 1270                 1275             


Gly Met  Ala Leu Asn Phe Ile  Arg Gln Gln Asn Phe  Arg Thr Gln 
    1280                 1285                 1290             


Ala Gly  Met Arg Pro Arg Ala  Arg Lys Ile Gly Val  Leu Ile Thr 
    1295                 1300                 1305             


Asp Gly  Lys Ser Gln Asp Asp  Val Glu Ala Pro Ser  Lys Lys Leu 
    1310                 1315                 1320             


Lys Asp  Glu Gly Val Glu Leu  Phe Ala Ile Gly Ile  Lys Asn Ala 
    1325                 1330                 1335             


Asp Glu  Val Glu Leu Lys Met  Ile Ala Thr Asp Pro  Asp Asp Thr 
    1340                 1345                 1350             


His Ala  Tyr Asn Val Ala Asp  Phe Glu Ser Leu Ser  Arg Ile Val 
    1355                 1360                 1365             


Asp Asp  Leu Thr Ile Asn Leu  Cys Asn Ser Val Lys  Gly Pro Gly 
    1370                 1375                 1380             


Asp Leu  Glu Ala Pro Ser Asn  Leu Val Ile Ser Glu  Arg Thr His 
    1385                 1390                 1395             


Arg Ser  Phe Arg Val Ser Trp  Thr Pro Pro Ser Asp  Ser Val Asp 
    1400                 1405                 1410             


Arg Tyr  Lys Val Glu Tyr Tyr  Pro Val Ser Gly Gly  Lys Arg Gln 
    1415                 1420                 1425             


Glu Phe  Tyr Val Ser Arg Met  Glu Thr Ser Thr Val  Leu Lys Asp 
    1430                 1435                 1440             


Leu Lys  Pro Glu Thr Glu Tyr  Val Val Asn Val Tyr  Ser Val Val 
    1445                 1450                 1455             


Glu Asp  Glu Tyr Ser Glu Pro  Leu Lys Gly Thr Glu  Lys Thr Leu 
    1460                 1465                 1470             


Pro Val  Pro Val Val Ser Leu  Asn Ile Tyr Asp Val  Gly Pro Thr 
    1475                 1480                 1485             


Thr Met  His Val Gln Trp Gln  Pro Val Gly Gly Ala  Thr Gly Tyr 
    1490                 1495                 1500             


Ile Leu  Ser Tyr Lys Pro Val  Lys Asp Thr Glu Pro  Thr Arg Pro 
    1505                 1510                 1515             


Lys Glu  Val Arg Leu Gly Pro  Thr Val Asn Asp Met  Gln Leu Thr 
    1520                 1525                 1530             


Asp Leu  Val Pro Asn Thr Glu  Tyr Ala Val Thr Val  Gln Ala Val 
    1535                 1540                 1545             


Leu His  Asp Leu Thr Ser Glu  Pro Val Thr Val Arg  Glu Val Thr 
    1550                 1555                 1560             


Leu Pro  Leu Pro Arg Pro Gln  Asp Leu Lys Leu Arg  Asp Val Thr 
    1565                 1570                 1575             


His Ser  Thr Met Asn Val Phe  Trp Glu Pro Val Pro  Gly Lys Val 
    1580                 1585                 1590             


Arg Lys  Tyr Ile Val Arg Tyr  Lys Thr Pro Glu Glu  Asp Val Lys 
    1595                 1600                 1605             


Glu Val  Glu Val Asp Arg Ser  Glu Thr Ser Thr Ser  Leu Lys Asp 
    1610                 1615                 1620             


Leu Phe  Ser Gln Thr Leu Tyr  Thr Val Ser Val Ser  Ala Val His 
    1625                 1630                 1635             


Asp Glu  Gly Glu Ser Pro Pro  Val Thr Ala Gln Glu  Thr Thr Arg 
    1640                 1645                 1650             


Pro Val  Pro Ala Pro Thr Asn  Leu Lys Ile Thr Glu  Val Thr Ser 
    1655                 1660                 1665             


Glu Gly  Phe Arg Gly Thr Trp  Asp His Gly Ala Ser  Asp Val Ser 
    1670                 1675                 1680             


Leu Tyr  Arg Ile Thr Trp Ala  Pro Phe Gly Ser Ser  Asp Lys Met 
    1685                 1690                 1695             


Glu Thr  Ile Leu Asn Gly Asp  Glu Asn Thr Leu Val  Phe Glu Asn 
    1700                 1705                 1710             


Leu Asn  Pro Asn Thr Ile Tyr  Glu Val Ser Ile Thr  Ala Ile Tyr 
    1715                 1720                 1725             


Pro Asp  Glu Ser Glu Ser Asp  Asp Leu Ile Gly Ser  Glu Arg Thr 
    1730                 1735                 1740             


Leu Pro  Ile Leu Thr Thr Gln  Ala Pro Lys Ser Gly  Pro Arg Asn 
    1745                 1750                 1755             


Leu Gln  Val Tyr Asn Ala Thr  Ser Asn Ser Leu Thr  Val Lys Trp 
    1760                 1765                 1770             


Asp Pro  Ala Ser Gly Arg Val  Gln Lys Tyr Arg Ile  Thr Tyr Gln 
    1775                 1780                 1785             


Pro Ser  Thr Gly Glu Gly Asn  Glu Gln Thr Thr Thr  Ile Gly Gly 
    1790                 1795                 1800             


Arg Gln  Asn Ser Val Val Leu  Gln Lys Leu Lys Pro  Asp Thr Pro 
    1805                 1810                 1815             


Tyr Thr  Ile Thr Val Ser Ser  Leu Tyr Pro Asp Gly  Glu Gly Gly 
    1820                 1825                 1830             


Arg Met  Thr Gly Arg Gly Lys  Thr Lys Pro Leu Asn  Thr Val Arg 
    1835                 1840                 1845             


Asn Leu  Arg Val Tyr Asp Pro  Ser Thr Ser Thr Leu  Asn Val Arg 
    1850                 1855                 1860             


Trp Asp  His Ala Glu Gly Asn  Pro Arg Gln Tyr Lys  Leu Phe Tyr 
    1865                 1870                 1875             


Ala Pro  Ala Ala Gly Gly Pro  Glu Glu Leu Val Pro  Ile Pro Gly 
    1880                 1885                 1890             


Asn Thr  Asn Tyr Ala Ile Leu  Arg Asn Leu Gln Pro  Asp Thr Ser 
    1895                 1900                 1905             


Tyr Thr  Val Thr Val Val Pro  Val Tyr Thr Glu Gly  Asp Gly Gly 
    1910                 1915                 1920             


Arg Thr  Ser Asp Thr Gly Arg  Thr Leu Met Arg Gly  Leu Ala Arg 
    1925                 1930                 1935             


Asn Val  Gln Val Tyr Asn Pro  Thr Pro Asn Ser Leu  Asp Val Arg 
    1940                 1945                 1950             


Trp Asp  Pro Ala Pro Gly Pro  Val Leu Gln Tyr Arg  Val Val Tyr 
    1955                 1960                 1965             


Ser Pro  Val Asp Gly Thr Arg  Pro Ser Glu Ser Ile  Val Val Pro 
    1970                 1975                 1980             


Gly Asn  Thr Arg Met Val His  Leu Glu Arg Leu Ile  Pro Asp Thr 
    1985                 1990                 1995             


Leu Tyr  Ser Val Asn Leu Val  Ala Leu Tyr Ser Asp  Gly Glu Gly 
    2000                 2005                 2010             


Asn Pro  Ser Pro Ala Gln Gly  Arg Thr Leu Pro Arg  Ser Gly Pro 
    2015                 2020                 2025             


Arg Asn  Leu Arg Val Phe Gly  Glu Thr Thr Asn Ser  Leu Ser Val 
    2030                 2035                 2040             


Ala Trp  Asp His Ala Asp Gly  Pro Val Gln Gln Tyr  Arg Ile Ile 
    2045                 2050                 2055             


Tyr Ser  Pro Thr Val Gly Asp  Pro Ile Asp Glu Tyr  Thr Thr Val 
    2060                 2065                 2070             


Pro Gly  Arg Arg Asn Asn Val  Ile Leu Gln Pro Leu  Gln Pro Asp 
    2075                 2080                 2085             


Thr Pro  Tyr Lys Ile Thr Val  Ile Ala Val Tyr Glu  Asp Gly Asp 
    2090                 2095                 2100             


Gly Gly  His Leu Thr Gly Asn  Gly Arg Thr Val Gly  Leu Leu Pro 
    2105                 2110                 2115             


Pro Gln  Asn Ile His Ile Ser  Asp Glu Trp Tyr Thr  Arg Phe Arg 
    2120                 2125                 2130             


Val Ser  Trp Asp Pro Ser Pro  Ser Pro Val Leu Gly  Tyr Lys Ile 
    2135                 2140                 2145             


Val Tyr  Lys Pro Val Gly Ser  Asn Glu Pro Met Glu  Ala Phe Val 
    2150                 2155                 2160             


Gly Glu  Met Thr Ser Tyr Thr  Leu His Asn Leu Asn  Pro Ser Thr 
    2165                 2170                 2175             


Thr Tyr  Asp Val Asn Val Tyr  Ala Gln Tyr Asp Ser  Gly Leu Ser 
    2180                 2185                 2190             


Val Pro  Leu Thr Asp Gln Gly  Thr Thr Leu Tyr Leu  Asn Val Thr 
    2195                 2200                 2205             


Asp Leu  Lys Thr Tyr Gln Ile  Gly Trp Asp Thr Phe  Cys Val Lys 
    2210                 2215                 2220             


Trp Ser  Pro His Arg Ala Ala  Thr Ser Tyr Arg Leu  Lys Leu Ser 
    2225                 2230                 2235             


Pro Ala  Asp Gly Thr Arg Gly  Gln Glu Ile Thr Val  Arg Gly Ser 
    2240                 2245                 2250             


Glu Thr  Ser His Cys Phe Thr  Gly Leu Ser Pro Asp  Thr Asp Tyr 
    2255                 2260                 2265             


Gly Val  Thr Val Phe Val Gln  Thr Pro Asn Leu Glu  Gly Pro Gly 
    2270                 2275                 2280             


Val Ser  Val Lys Glu His Thr  Thr Val Lys Pro Thr  Glu Ala Pro 
    2285                 2290                 2295             


Thr Glu  Pro Pro Thr Pro Pro  Pro Pro Pro Thr Ile  Pro Pro Ala 
    2300                 2305                 2310             


Arg Asp  Val Cys Lys Gly Ala  Lys Ala Asp Ile Val  Phe Leu Thr 
    2315                 2320                 2325             


Asp Ala  Ser Trp Ser Ile Gly  Asp Asp Asn Phe Asn  Lys Val Val 
    2330                 2335                 2340             


Lys Phe  Ile Phe Asn Thr Val  Gly Gly Phe Asp Glu  Ile Ser Pro 
    2345                 2350                 2355             


Ala Gly  Ile Gln Val Ser Phe  Val Gln Tyr Ser Asp  Glu Val Lys 
    2360                 2365                 2370             


Ser Glu  Phe Lys Leu Asn Thr  Tyr Asn Asp Lys Ala  Leu Ala Leu 
    2375                 2380                 2385             


Gly Ala  Leu Gln Asn Ile Arg  Tyr Arg Gly Gly Asn  Thr Arg Thr 
    2390                 2395                 2400             


Gly Lys  Ala Leu Thr Phe Ile  Lys Glu Lys Val Leu  Thr Trp Glu 
    2405                 2410                 2415             


Ser Gly  Met Arg Lys Asn Val  Pro Lys Val Leu Val  Val Val Thr 
    2420                 2425                 2430             


Asp Gly  Arg Ser Gln Asp Glu  Val Lys Lys Ala Ala  Leu Val Ile 
    2435                 2440                 2445             


Gln Gln  Ser Gly Phe Ser Val  Phe Val Val Gly Val  Ala Asp Val 
    2450                 2455                 2460             


Asp Tyr  Asn Glu Leu Ala Asn  Ile Ala Ser Lys Pro  Ser Glu Arg 
    2465                 2470                 2475             


His Val  Phe Ile Val Asp Asp  Phe Glu Ser Phe Glu  Lys Ile Glu 
    2480                 2485                 2490             


Asp Asn  Leu Ile Thr Phe Val  Cys Glu Thr Ala Thr  Ser Ser Cys 
    2495                 2500                 2505             


Pro Leu  Ile Tyr Leu Asp Gly  Tyr Thr Ser Pro Gly  Phe Lys Met 
    2510                 2515                 2520             


Leu Glu  Ala Tyr Asn Leu Thr  Glu Lys Asn Phe Ala  Ser Val Gln 
    2525                 2530                 2535             


Gly Val  Ser Leu Glu Ser Gly  Ser Phe Pro Ser Tyr  Ser Ala Tyr 
    2540                 2545                 2550             


Arg Ile  Gln Lys Asn Ala Phe  Val Asn Gln Pro Thr  Ala Asp Leu 
    2555                 2560                 2565             


His Pro  Asn Gly Leu Pro Pro  Ser Tyr Thr Ile Ile  Leu Leu Phe 
    2570                 2575                 2580             


Arg Leu  Leu Pro Glu Thr Pro  Ser Asp Pro Phe Ala  Ile Trp Gln 
    2585                 2590                 2595             


Ile Thr  Asp Arg Asp Tyr Lys  Pro Gln Val Gly Val  Ile Ala Asp 
    2600                 2605                 2610             


Pro Ser  Ser Lys Thr Leu Ser  Phe Phe Asn Lys Asp  Thr Arg Gly 
    2615                 2620                 2625             


Glu Val  Gln Thr Val Thr Phe  Asp Thr Glu Glu Val  Lys Thr Leu 
    2630                 2635                 2640             


Phe Tyr  Gly Ser Phe His Lys  Arg Asp Glu Gly Lys  Cys Pro Ala 
    2645                 2650                 2655             


Phe Pro  Asn Ser Cys Thr Cys  Thr Gln Asp Ser Val  Gly Pro Pro 
    2660                 2665                 2670             


Gly Pro  Pro Gly Pro Ala Gly  Gly Pro Gly Ala Lys  Gly Pro Arg 
    2675                 2680                 2685             


Gly Glu  Arg Gly Ile Ser Gly  Ala Ile Gly Pro Pro  Gly Pro Arg 
    2690                 2695                 2700             


Gly Asp  Ile Gly Pro Pro Gly  Pro Gln Gly Pro Pro  Gly Pro Gln 
    2705                 2710                 2715             


Gly Pro  Asn Gly Leu Ser Ile  Pro Gly Glu Gln Gly  Arg Gln Gly 
    2720                 2725                 2730             


Met Lys  Gly Asp Ala Gly Glu  Pro Gly Leu Pro Gly  Arg Thr Gly 
    2735                 2740                 2745             


Thr Pro  Gly Leu Pro Gly Pro  Pro Gly Pro Met Gly  Pro Pro Gly 
    2750                 2755                 2760             


Asp Arg  Gly Phe Thr Gly Lys  Asp Gly Ala Met Gly  Pro Arg Gly 
    2765                 2770                 2775             


Pro Pro  Gly Pro Pro Gly Ser  Pro Gly Ser Pro Gly  Val Thr Gly 
    2780                 2785                 2790             


Pro Ser  Gly Lys Pro Gly Lys  Pro Gly Asp His Gly  Arg Pro Gly 
    2795                 2800                 2805             


Pro Ser  Gly Leu Lys Gly Glu  Lys Gly Asp Arg Gly  Asp Ile Ala 
    2810                 2815                 2820             


Ser Gln  Asn Met Met Arg Ala  Val Ala Arg Gln Val  Cys Glu Gln 
    2825                 2830                 2835             


Leu Ile  Ser Gly Gln Met Asn  Arg Phe Asn Gln Met  Leu Asn Gln 
    2840                 2845                 2850             


Ile Pro  Asn Asp Tyr Gln Ser  Ser Arg Asn Gln Pro  Gly Pro Pro 
    2855                 2860                 2865             


Gly Pro  Pro Gly Pro Pro Gly  Ser Ala Gly Ala Arg  Gly Glu Pro 
    2870                 2875                 2880             


Gly Pro  Gly Gly Arg Pro Gly  Phe Pro Gly Thr Pro  Gly Met Gln 
    2885                 2890                 2895             


Gly Pro  Pro Gly Glu Arg Gly  Leu Pro Gly Glu Lys  Gly Glu Arg 
    2900                 2905                 2910             


Gly Thr  Gly Ser Ser Gly Pro  Arg Gly Leu Pro Gly  Pro Pro Gly 
    2915                 2920                 2925             


Pro Gln  Gly Glu Ser Arg Thr  Gly Pro Pro Gly Ser  Thr Gly Ser 
    2930                 2935                 2940             


Arg Gly  Pro Pro Gly Pro Pro  Gly Arg Pro Gly Asn  Ser Gly Ile 
    2945                 2950                 2955             


Arg Gly  Pro Pro Gly Pro Pro  Gly Tyr Cys Asp Ser  Ser Gln Cys 
    2960                 2965                 2970             


Ala Ser  Ile Pro Tyr Asn Gly  Gln Gly Tyr Pro Gly  Ser Gly 
    2975                 2980                 2985         


<210>  3228
<211>  207
<212>  PRT
<213>  Homo Sapiens

<400>  3228

Val Ile Gln Gln Ser Gly Phe Ser Val Phe Val Val Gly Val Ala Asp 
1               5                   10                  15      


Val Asp Tyr Asn Glu Leu Ala Asn Ile Ala Ser Lys Pro Ser Glu Arg 
            20                  25                  30          


His Val Phe Ile Val Asp Asp Phe Glu Ser Phe Glu Lys Ile Glu Asp 
        35                  40                  45              


Asn Leu Ile Thr Phe Val Cys Glu Thr Ala Thr Ser Ser Cys Pro Leu 
    50                  55                  60                  


Ile Tyr Leu Asp Gly Tyr Thr Ser Pro Gly Phe Lys Met Leu Glu Ala 
65                  70                  75                  80  


Tyr Asn Leu Thr Glu Lys Asn Phe Ala Ser Val Gln Gly Val Ser Leu 
                85                  90                  95      


Glu Ser Gly Ser Phe Pro Ser Tyr Ser Ala Tyr Arg Ile Gln Lys Asn 
            100                 105                 110         


Ala Phe Val Asn Gln Pro Thr Ala Asp Leu His Pro Asn Gly Leu Pro 
        115                 120                 125             


Pro Ser Tyr Thr Ile Ile Leu Leu Phe Arg Leu Leu Pro Glu Thr Pro 
    130                 135                 140                 


Ser Asp Pro Phe Ala Ile Trp Gln Ile Thr Asp Arg Asp Tyr Lys Pro 
145                 150                 155                 160 


Gln Val Gly Val Ile Ala Asp Pro Ser Ser Lys Thr Leu Ser Phe Phe 
                165                 170                 175     


Asn Lys Asp Thr Arg Gly Glu Val Gln Thr Val Thr Phe Asp Thr Glu 
            180                 185                 190         


Glu Val Lys Thr Leu Phe Tyr Gly Ser Phe His Lys Val Lys Thr 
        195                 200                 205         


<210>  3229
<211>  756
<212>  PRT
<213>  Homo Sapiens

<400>  3229

Val Ser Phe Val Gln Tyr Ser Asp Glu Val Lys Ser Glu Phe Lys Leu 
1               5                   10                  15      


Asn Thr Tyr Asn Asp Lys Ala Leu Ala Leu Gly Ala Leu Gln Asn Ile 
            20                  25                  30          


Arg Tyr Arg Gly Gly Asn Thr Arg Thr Gly Lys Ala Leu Thr Phe Ile 
        35                  40                  45              


Lys Glu Lys Val Leu Thr Trp Glu Ser Gly Met Arg Lys Asn Val Pro 
    50                  55                  60                  


Lys Val Leu Val Val Val Thr Asp Gly Arg Ser Gln Asp Glu Val Lys 
65                  70                  75                  80  


Lys Ala Ala Leu Val Ile Gln Gln Ser Gly Phe Ser Val Phe Val Val 
                85                  90                  95      


Gly Val Ala Asp Val Asp Tyr Asn Glu Leu Ala Asn Ile Ala Ser Lys 
            100                 105                 110         


Pro Ser Glu Arg His Val Phe Ile Val Asp Asp Phe Glu Ser Phe Glu 
        115                 120                 125             


Lys Ile Glu Asp Asn Leu Ile Thr Phe Val Cys Glu Thr Ala Thr Ser 
    130                 135                 140                 


Ser Cys Pro Leu Ile Tyr Leu Asp Gly Tyr Thr Ser Pro Gly Phe Lys 
145                 150                 155                 160 


Met Leu Glu Ala Tyr Asn Leu Thr Glu Lys Asn Phe Ala Ser Val Gln 
                165                 170                 175     


Gly Val Ser Leu Glu Ser Gly Ser Phe Pro Ser Tyr Ser Ala Tyr Arg 
            180                 185                 190         


Ile Gln Lys Asn Ala Phe Val Asn Gln Pro Thr Ala Asp Leu His Pro 
        195                 200                 205             


Asn Gly Leu Pro Pro Ser Tyr Thr Ile Ile Leu Leu Phe Arg Leu Leu 
    210                 215                 220                 


Pro Glu Thr Pro Ser Asp Pro Phe Ala Ile Trp Gln Ile Thr Asp Arg 
225                 230                 235                 240 


Asp Tyr Lys Pro Gln Val Gly Val Ile Ala Asp Pro Ser Ser Lys Thr 
                245                 250                 255     


Leu Ser Phe Phe Asn Lys Asp Thr Arg Gly Glu Val Gln Thr Val Thr 
            260                 265                 270         


Phe Asp Thr Glu Glu Val Lys Thr Leu Phe Tyr Gly Ser Phe His Lys 
        275                 280                 285             


Val His Ile Val Val Thr Ser Lys Ser Val Lys Ile Tyr Ile Asp Cys 
    290                 295                 300                 


Tyr Glu Ile Ile Glu Lys Asp Ile Lys Glu Ala Gly Asn Ile Thr Thr 
305                 310                 315                 320 


Asp Gly Tyr Glu Ile Leu Gly Lys Leu Leu Lys Gly Glu Arg Lys Ser 
                325                 330                 335     


Ala Ala Phe Gln Ile Gln Ser Phe Asp Ile Val Cys Ser Pro Val Trp 
            340                 345                 350         


Thr Ser Arg Asp Arg Cys Cys Asp Ile Pro Ser Arg Arg Asp Glu Gly 
        355                 360                 365             


Lys Cys Pro Ala Phe Pro Asn Ser Cys Thr Cys Thr Gln Asp Ser Val 
    370                 375                 380                 


Gly Pro Pro Gly Pro Pro Gly Pro Ala Gly Gly Pro Gly Ala Lys Gly 
385                 390                 395                 400 


Pro Arg Gly Glu Arg Gly Ile Ser Gly Ala Ile Gly Pro Pro Gly Pro 
                405                 410                 415     


Arg Gly Asp Ile Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly Pro Gln 
            420                 425                 430         


Gly Pro Asn Gly Leu Ser Ile Pro Gly Glu Gln Gly Arg Gln Gly Met 
        435                 440                 445             


Lys Gly Asp Ala Gly Glu Pro Gly Leu Pro Gly Arg Thr Gly Thr Pro 
    450                 455                 460                 


Gly Leu Pro Gly Pro Pro Gly Pro Met Gly Pro Pro Gly Asp Arg Gly 
465                 470                 475                 480 


Phe Thr Gly Lys Asp Gly Ala Met Gly Pro Arg Gly Pro Pro Gly Pro 
                485                 490                 495     


Pro Gly Ser Pro Gly Ser Pro Gly Val Thr Gly Pro Ser Gly Lys Pro 
            500                 505                 510         


Gly Lys Pro Gly Asp His Gly Arg Pro Gly Pro Ser Gly Leu Lys Gly 
        515                 520                 525             


Glu Lys Gly Asp Arg Gly Asp Ile Ala Ser Gln Asn Met Met Arg Ala 
    530                 535                 540                 


Val Ala Arg Gln Val Cys Glu Gln Leu Ile Ser Gly Gln Met Asn Arg 
545                 550                 555                 560 


Phe Asn Gln Met Leu Asn Gln Ile Pro Asn Asp Tyr Gln Ser Ser Arg 
                565                 570                 575     


Asn Gln Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Ser Ala Gly 
            580                 585                 590         


Ala Arg Gly Glu Pro Gly Pro Gly Gly Arg Pro Gly Phe Pro Gly Thr 
        595                 600                 605             


Pro Gly Met Gln Gly Pro Pro Gly Glu Arg Gly Leu Pro Gly Glu Lys 
    610                 615                 620                 


Gly Glu Arg Gly Thr Gly Ser Ser Gly Pro Arg Gly Leu Pro Gly Pro 
625                 630                 635                 640 


Pro Gly Pro Gln Gly Glu Ser Arg Thr Gly Pro Pro Gly Ser Thr Gly 
                645                 650                 655     


Ser Arg Gly Pro Pro Gly Pro Pro Gly Arg Pro Gly Asn Ser Gly Ile 
            660                 665                 670         


Arg Gly Pro Pro Gly Pro Pro Gly Tyr Cys Asp Ser Ser Gln Cys Ala 
        675                 680                 685             


Ser Ile Pro Tyr Asn Gly Gln Gly Tyr Pro Glu Pro Tyr Val Pro Glu 
    690                 695                 700                 


Gly Gly Ala Tyr Leu Pro Glu Arg Glu Pro Phe Ile Val Pro Val Glu 
705                 710                 715                 720 


Pro Glu Arg Thr Ala Glu Tyr Glu Asp Tyr Gly Ala Asp Glu Pro Ala 
                725                 730                 735     


Glu Glu Pro Pro Glu Pro His Arg Arg Trp Arg Arg Ala Leu Pro His 
            740                 745                 750         


Gly Pro Gly Gln 
        755     


<210>  3230
<211>  638
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3230

Xaa Lys Ser Leu Leu Gln Ala Val Ala Asn Leu Pro Tyr Lys Gly Gly 
1               5                   10                  15      


Asn Thr Leu Thr Gly Met Ala Leu Asn Phe Ile Arg Gln Gln Asn Phe 
            20                  25                  30          


Arg Thr Gln Ala Gly Met Arg Pro Arg Ala Arg Lys Ile Gly Val Leu 
        35                  40                  45              


Ile Thr Asp Gly Lys Ser Gln Asp Asp Val Glu Ala Pro Ser Lys Lys 
    50                  55                  60                  


Leu Lys Asp Glu Gly Val Glu Leu Phe Ala Ile Gly Ile Lys Asn Ala 
65                  70                  75                  80  


Asp Glu Val Glu Leu Lys Met Ile Ala Thr Asp Pro Asp Asp Thr His 
                85                  90                  95      


Ala Tyr Asn Val Ala Asp Phe Glu Ser Leu Ser Arg Ile Val Asp Asp 
            100                 105                 110         


Leu Thr Ile Asn Leu Cys Asn Ser Val Lys Gly Pro Gly Asp Leu Glu 
        115                 120                 125             


Ala Pro Ser Asn Leu Val Ile Ser Glu Arg Thr His Arg Ser Phe Arg 
    130                 135                 140                 


Val Ser Trp Thr Pro Pro Ser Asp Ser Val Asp Arg Tyr Lys Val Glu 
145                 150                 155                 160 


Tyr Tyr Pro Val Ser Gly Gly Lys Arg Gln Glu Phe Tyr Val Ser Arg 
                165                 170                 175     


Met Glu Thr Ser Thr Val Leu Lys Asp Leu Lys Pro Glu Thr Glu Tyr 
            180                 185                 190         


Val Val Asn Val Tyr Ser Val Val Glu Asp Glu Tyr Ser Glu Pro Leu 
        195                 200                 205             


Lys Gly Thr Glu Lys Thr Leu Pro Val Pro Val Val Ser Leu Asn Ile 
    210                 215                 220                 


Tyr Asp Val Gly Pro Thr Thr Met His Val Gln Trp Gln Pro Val Gly 
225                 230                 235                 240 


Gly Ala Thr Gly Tyr Ile Leu Ser Tyr Lys Pro Val Lys Asp Thr Glu 
                245                 250                 255     


Pro Thr Arg Pro Lys Glu Val Arg Leu Gly Pro Thr Val Asn Asp Met 
            260                 265                 270         


Gln Leu Thr Asp Leu Val Pro Asn Thr Glu Tyr Ala Val Thr Val Gln 
        275                 280                 285             


Ala Val Leu His Asp Leu Thr Ser Glu Pro Val Thr Val Arg Glu Val 
    290                 295                 300                 


Thr Leu Pro Leu Pro Arg Pro Gln Asp Leu Lys Leu Arg Asp Val Thr 
305                 310                 315                 320 


His Ser Thr Met Asn Val Phe Trp Glu Pro Val Pro Gly Lys Val Arg 
                325                 330                 335     


Lys Tyr Ile Val Arg Tyr Lys Thr Pro Glu Glu Asp Val Lys Glu Val 
            340                 345                 350         


Glu Val Asp Arg Ser Glu Thr Ser Thr Ser Leu Lys Asp Leu Phe Ser 
        355                 360                 365             


Gln Thr Leu Tyr Thr Val Ser Val Ser Ala Val His Asp Glu Gly Glu 
    370                 375                 380                 


Ser Pro Pro Val Thr Ala Gln Glu Thr Thr Arg Pro Val Pro Ala Pro 
385                 390                 395                 400 


Thr Asn Leu Lys Ile Thr Glu Val Thr Ser Glu Gly Phe Arg Gly Thr 
                405                 410                 415     


Trp Asp His Gly Ala Ser Asp Val Ser Leu Tyr Arg Ile Thr Trp Ala 
            420                 425                 430         


Pro Phe Gly Ser Ser Asp Lys Met Glu Thr Ile Leu Asn Gly Asp Glu 
        435                 440                 445             


Asn Thr Leu Val Phe Glu Asn Leu Asn Pro Asn Thr Ile Tyr Glu Val 
    450                 455                 460                 


Ser Ile Thr Ala Ile Tyr Pro Asp Glu Ser Glu Ser Asp Asp Leu Ile 
465                 470                 475                 480 


Gly Ser Glu Arg Thr Pro Pro Lys Ser Gly Pro Arg Asn Leu Gln Val 
                485                 490                 495     


Tyr Asn Ala Thr Ser Asn Ser Leu Thr Val Lys Trp Asp Pro Ala Ser 
            500                 505                 510         


Gly Arg Val Gln Lys Tyr Arg Ile Thr Tyr Gln Pro Ser Thr Gly Glu 
        515                 520                 525             


Gly Asn Glu Gln Thr Thr Thr Ile Gly Gly Arg Gln Asn Ser Val Val 
    530                 535                 540                 


Leu Gln Lys Leu Lys Pro Asp Thr Pro Tyr Thr Ile Thr Val Ser Ser 
545                 550                 555                 560 


Leu Tyr Pro Asp Gly Glu Gly Gly Arg Met Thr Gly Arg Gly Lys Thr 
                565                 570                 575     


Lys Pro Leu Asn Thr Val Arg Asn Leu Arg Val Tyr Asp Pro Ser Thr 
            580                 585                 590         


Ser Thr Leu Asn Val Arg Trp Asp His Ala Glu Gly Asn Pro Arg Gln 
        595                 600                 605             


Tyr Lys Leu Phe Tyr Ala Pro Ala Ala Gly Gly Pro Glu Glu Leu Val 
    610                 615                 620                 


Pro Ile Pro Gly Asn Thr Asn Tyr Ala Ile Leu Arg Asn Leu 
625                 630                 635             


<210>  3231
<211>  843
<212>  PRT
<213>  Homo Sapiens

<400>  3231

Phe Asp Val Gly Ser Glu Lys Thr Arg Ile Gly Leu Ala Gln Tyr Ser 
1               5                   10                  15      


Gly Asp Pro Arg Ile Glu Trp His Leu Asn Ala Phe Ser Thr Lys Asp 
            20                  25                  30          


Glu Val Ile Glu Ala Val Arg Asn Leu Pro Tyr Lys Gly Gly Asn Thr 
        35                  40                  45              


Leu Thr Gly Leu Ala Leu Asn Tyr Ile Phe Glu Asn Ser Phe Lys Pro 
    50                  55                  60                  


Glu Ala Gly Ser Arg Thr Gly Val Ser Lys Ile Gly Ile Leu Ile Thr 
65                  70                  75                  80  


Asp Gly Lys Ser Gln Asp Asp Ile Ile Pro Pro Ser Arg Asn Leu Arg 
                85                  90                  95      


Glu Ser Gly Val Glu Leu Phe Ala Ile Gly Val Lys Asn Ala Asp Val 
            100                 105                 110         


Asn Glu Leu Gln Glu Ile Ala Ser Glu Pro Asp Ser Thr His Val Tyr 
        115                 120                 125             


Asn Val Ala Glu Phe Asp Leu Met His Thr Val Val Glu Ser Leu Thr 
    130                 135                 140                 


Arg Thr Leu Cys Ser Arg Val Glu Glu Gln Asp Arg Glu Ile Lys Ala 
145                 150                 155                 160 


Ser Ala His Ala Ile Thr Gly Pro Pro Thr Glu Leu Ile Thr Ser Glu 
                165                 170                 175     


Val Thr Ala Arg Ser Phe Met Val Asn Trp Thr His Ala Pro Gly Asn 
            180                 185                 190         


Val Glu Lys Tyr Arg Val Val Tyr Tyr Pro Thr Arg Gly Gly Lys Pro 
        195                 200                 205             


Asp Glu Val Val Val Asp Gly Thr Val Ser Ser Thr Val Leu Lys Asn 
    210                 215                 220                 


Leu Met Ser Leu Thr Glu Tyr Gln Ile Ala Val Phe Ala Ile Tyr Ala 
225                 230                 235                 240 


His Thr Ala Ser Glu Gly Leu Arg Gly Thr Glu Thr Thr Leu Ala Leu 
                245                 250                 255     


Pro Met Ala Ser Asp Leu Leu Leu Tyr Asp Val Thr Glu Asn Ser Met 
            260                 265                 270         


Arg Val Lys Trp Asp Ala Val Pro Gly Ala Ser Gly Tyr Leu Ile Leu 
        275                 280                 285             


Tyr Ala Pro Leu Thr Glu Gly Leu Ala Gly Asp Glu Lys Glu Met Lys 
    290                 295                 300                 


Ile Gly Glu Thr His Thr Asp Ile Glu Leu Ser Gly Leu Leu Pro Asn 
305                 310                 315                 320 


Thr Glu Tyr Thr Val Thr Val Tyr Ala Met Phe Gly Glu Glu Ala Ser 
                325                 330                 335     


Asp Pro Val Thr Gly Gln Glu Thr Thr Leu Ala Leu Ser Pro Pro Arg 
            340                 345                 350         


Asn Leu Arg Ile Ser Asn Val Gly Ser Asn Ser Ala Arg Leu Thr Trp 
        355                 360                 365             


Asp Pro Thr Ser Arg Gln Ile Asn Gly Tyr Arg Ile Val Tyr Asn Asn 
    370                 375                 380                 


Ala Asp Gly Thr Glu Ile Asn Glu Val Glu Val Asp Pro Ile Thr Thr 
385                 390                 395                 400 


Phe Pro Leu Lys Gly Leu Thr Pro Leu Thr Glu Tyr Thr Ile Ala Ile 
                405                 410                 415     


Phe Ser Ile Tyr Asp Glu Gly Gln Ser Glu Pro Leu Thr Gly Val Phe 
            420                 425                 430         


Thr Thr Glu Glu Val Pro Ala Gln Gln Tyr Leu Glu Ile Asp Glu Val 
        435                 440                 445             


Thr Thr Asp Ser Phe Arg Val Thr Trp His Pro Leu Ser Ala Asp Glu 
    450                 455                 460                 


Gly Leu His Lys Leu Met Trp Ile Pro Val Tyr Gly Gly Lys Thr Glu 
465                 470                 475                 480 


Glu Val Val Leu Lys Glu Glu Gln Asp Ser His Val Ile Glu Gly Leu 
                485                 490                 495     


Glu Pro Gly Thr Glu Tyr Glu Val Ser Leu Leu Ala Val Leu Asp Asp 
            500                 505                 510         


Gly Ser Glu Ser Glu Val Val Thr Ala Val Gly Thr Thr Leu Asp Ser 
        515                 520                 525             


Phe Trp Thr Glu Pro Ala Thr Thr Ile Val Pro Thr Thr Ser Val Thr 
    530                 535                 540                 


Ser Val Phe Gln Thr Gly Ile Arg Asn Leu Val Val Gly Asp Glu Thr 
545                 550                 555                 560 


Thr Ser Ser Leu Arg Val Lys Trp Asp Ile Ser Asp Ser Asp Val Gln 
                565                 570                 575     


Gln Phe Arg Val Thr Tyr Met Thr Ala Gln Gly Asp Pro Glu Glu Glu 
            580                 585                 590         


Val Ile Gly Thr Val Met Val Pro Gly Ser Gln Asn Asn Leu Leu Leu 
        595                 600                 605             


Lys Pro Leu Leu Pro Asp Thr Glu Tyr Lys Val Thr Val Thr Pro Ile 
    610                 615                 620                 


Tyr Thr Asp Gly Glu Gly Val Ser Val Ser Ala Pro Gly Lys Thr Leu 
625                 630                 635                 640 


Pro Ser Ser Gly Pro Gln Asn Leu Arg Val Ser Glu Glu Trp Tyr Asn 
                645                 650                 655     


Arg Leu Arg Ile Thr Trp Asp Pro Pro Ser Ser Pro Val Lys Gly Tyr 
            660                 665                 670         


Arg Ile Val Tyr Lys Pro Val Ser Val Pro Gly Pro Thr Leu Glu Thr 
        675                 680                 685             


Phe Val Gly Ala Asp Ile Asn Thr Ile Leu Ile Thr Asn Leu Leu Ser 
    690                 695                 700                 


Gly Met Asp Tyr Asn Val Lys Ile Phe Ala Ser Gln Ala Ser Gly Phe 
705                 710                 715                 720 


Ser Asp Ala Leu Thr Gly Met Val Lys Thr Leu Phe Leu Gly Val Thr 
                725                 730                 735     


Asn Leu Gln Ala Lys His Val Glu Met Thr Ser Leu Cys Ala His Trp 
            740                 745                 750         


Gln Val His Arg His Ala Thr Ala Tyr Arg Val Val Ile Glu Ser Leu 
        755                 760                 765             


Gln Asp Arg Gln Lys Gln Glu Ser Thr Val Gly Gly Gly Thr Thr Arg 
    770                 775                 780                 


His Cys Phe Tyr Gly Leu Gln Pro Asp Ser Glu Tyr Lys Ile Ser Val 
785                 790                 795                 800 


Tyr Thr Lys Leu Gln Glu Ile Glu Gly Pro Ser Val Ser Ile Met Glu 
                805                 810                 815     


Lys Thr Gln Ser Leu Pro Thr Arg Pro Pro Thr Phe Pro Pro Thr Ile 
            820                 825                 830         


Pro Pro Ala Lys Glu Gly Lys Arg Ile Ile Glu 
        835                 840             


<210>  3232
<211>  149
<212>  PRT
<213>  Homo Sapiens

<400>  3232

Gly Pro Pro Gly Glu Pro Gly Arg Pro Gly Ser Pro Gly Ala Pro Gly 
1               5                   10                  15      


Glu Gln Gly Pro Pro Gly Thr Pro Gly Phe Pro Gly Asn Ala Gly Val 
            20                  25                  30          


Pro Gly Thr Pro Gly Glu Arg Gly Leu Thr Gly Ile Lys Gly Glu Lys 
        35                  40                  45              


Gly Asn Pro Gly Val Gly Thr Gln Gly Pro Arg Gly Pro Pro Gly Pro 
    50                  55                  60                  


Ala Gly Pro Ser Gly Glu Ser Arg Pro Gly Ser Pro Gly Pro Pro Gly 
65                  70                  75                  80  


Ser Pro Gly Pro Arg Gly Pro Pro Gly His Leu Gly Val Pro Gly Pro 
                85                  90                  95      


Gln Gly Pro Ser Gly Gln Pro Gly Tyr Cys Asp Pro Ser Ser Cys Ser 
            100                 105                 110         


Ala Tyr Gly Val Arg Gly Trp Met Gly Ile Phe Leu Leu Asp His Pro 
        115                 120                 125             


Thr Leu Pro Ser Ser Pro Asp His Leu Pro Ser Leu Leu Phe Pro Gly 
    130                 135                 140                 


Asp Gly Leu Leu Thr 
145                 


<210>  3233
<211>  757
<212>  PRT
<213>  Homo Sapiens

<400>  3233

Met Asp Pro Gly Ala Leu Glu Met Lys Asn Lys Ile Ile Ser Phe Leu 
1               5                   10                  15      


Tyr Ser Thr Val Gly Ala Leu Asn Lys Ile Gly Thr Asp Gly Thr Gln 
            20                  25                  30          


Val Ala Met Val Gln Phe Thr Asp Asp Pro Arg Thr Glu Phe Lys Leu 
        35                  40                  45              


Asn Ala Tyr Lys Thr Lys Glu Thr Leu Leu Asp Ala Ile Lys His Ile 
    50                  55                  60                  


Ser Tyr Lys Gly Gly Asn Thr Lys Thr Gly Lys Ala Ile Lys Tyr Val 
65                  70                  75                  80  


Arg Asp Thr Leu Phe Thr Ala Glu Ser Gly Thr Arg Arg Gly Ile Pro 
                85                  90                  95      


Lys Val Ile Val Val Ile Thr Asp Gly Arg Ser Gln Asp Asp Val Asn 
            100                 105                 110         


Lys Ile Ser Arg Glu Met Gln Leu Asp Gly Tyr Ser Ile Phe Ala Ile 
        115                 120                 125             


Gly Val Ala Asp Ala Asp Tyr Ser Glu Leu Val Ser Ile Gly Ser Lys 
    130                 135                 140                 


Pro Ser Ala Arg His Val Phe Phe Val Asp Asp Phe Asp Ala Phe Lys 
145                 150                 155                 160 


Lys Ile Glu Asp Glu Leu Ile Thr Phe Val Cys Glu Thr Ala Ser Ala 
                165                 170                 175     


Thr Cys Pro Val Val His Lys Asp Gly Ile Asp Leu Ala Gly Phe Lys 
            180                 185                 190         


Met Met Glu Met Phe Gly Leu Val Glu Lys Asp Phe Ser Ser Val Glu 
        195                 200                 205             


Gly Val Ser Met Glu Pro Gly Thr Phe Asn Val Phe Pro Cys Tyr Gln 
    210                 215                 220                 


Leu His Lys Asp Ala Leu Val Ser Gln Pro Thr Arg Tyr Leu His Pro 
225                 230                 235                 240 


Glu Gly Leu Pro Ser Asp Tyr Thr Ile Ser Phe Leu Phe Arg Ile Leu 
                245                 250                 255     


Pro Asp Thr Pro Gln Glu Pro Phe Ala Leu Trp Glu Ile Leu Asn Lys 
            260                 265                 270         


Asn Ser Asp Pro Leu Val Gly Val Ile Leu Asp Asn Gly Gly Lys Thr 
        275                 280                 285             


Leu Thr Tyr Phe Asn Tyr Asp Gln Ser Gly Asp Phe Gln Thr Val Thr 
    290                 295                 300                 


Phe Glu Gly Pro Glu Ile Arg Lys Ile Phe Tyr Gly Ser Phe His Lys 
305                 310                 315                 320 


Leu His Ile Val Val Ser Glu Thr Leu Val Lys Val Val Ile Asp Cys 
                325                 330                 335     


Lys Gln Val Gly Glu Lys Ala Met Asn Ala Ser Ala Asn Ile Thr Ser 
            340                 345                 350         


Asp Gly Val Glu Val Leu Gly Lys Met Val Arg Ser Arg Gly Pro Gly 
        355                 360                 365             


Gly Asn Ser Ala Pro Phe Gln Leu Gln Met Phe Asp Ile Val Cys Ser 
    370                 375                 380                 


Thr Ser Trp Ala Asn Thr Asp Lys Cys Cys Glu Leu Pro Gly Leu Arg 
385                 390                 395                 400 


Asp Asp Glu Ser Cys Pro Asp Leu Pro His Ser Cys Ser Cys Ser Glu 
                405                 410                 415     


Thr Asn Glu Val Ala Leu Gly Pro Ala Gly Pro Pro Gly Gly Pro Gly 
            420                 425                 430         


Leu Arg Gly Pro Lys Gly Gln Gln Gly Glu Pro Gly Pro Lys Gly Pro 
        435                 440                 445             


Asp Gly Pro Arg Gly Glu Ile Gly Leu Pro Gly Pro Gln Gly Pro Pro 
    450                 455                 460                 


Gly Pro Gln Gly Pro Ser Gly Leu Ser Ile Gln Gly Met Pro Gly Met 
465                 470                 475                 480 


Pro Gly Glu Lys Gly Glu Lys Gly Asp Thr Gly Leu Pro Gly Pro Gln 
                485                 490                 495     


Gly Ile Pro Gly Gly Val Gly Ser Pro Gly Arg Asp Gly Ser Pro Gly 
            500                 505                 510         


Gln Arg Gly Leu Pro Gly Lys Asp Gly Ser Ser Gly Pro Pro Gly Pro 
        515                 520                 525             


Pro Gly Pro Ile Gly Ile Pro Gly Thr Pro Gly Val Pro Gly Ile Thr 
    530                 535                 540                 


Gly Ser Met Gly Pro Gln Gly Ala Leu Gly Pro Pro Gly Val Pro Gly 
545                 550                 555                 560 


Ala Lys Gly Glu Arg Gly Glu Arg Gly Asp Leu Gln Ser Gln Ala Met 
                565                 570                 575     


Val Arg Ser Val Ala Arg Gln Val Cys Glu Gln Leu Ile Gln Ser His 
            580                 585                 590         


Met Ala Arg Tyr Thr Ala Ile Leu Asn Gln Ile Pro Ser His Ser Ser 
        595                 600                 605             


Ser Ile Arg Thr Val Gln Gly Pro Pro Gly Glu Pro Gly Arg Pro Gly 
    610                 615                 620                 


Ser Pro Gly Ala Pro Gly Glu Gln Gly Pro Pro Gly Thr Pro Gly Phe 
625                 630                 635                 640 


Pro Gly Asn Ala Gly Val Pro Gly Thr Pro Gly Glu Arg Gly Leu Thr 
                645                 650                 655     


Gly Ile Lys Gly Glu Lys Gly Asn Pro Gly Val Gly Thr Gln Gly Pro 
            660                 665                 670         


Arg Gly Pro Pro Gly Pro Ala Gly Pro Ser Gly Glu Ser Arg Pro Gly 
        675                 680                 685             


Ser Pro Gly Pro Pro Gly Ser Pro Gly Pro Arg Gly Pro Pro Gly His 
    690                 695                 700                 


Leu Gly Val Pro Gly Pro Gln Gly Pro Ser Gly Gln Pro Gly Tyr Cys 
705                 710                 715                 720 


Asp Pro Ser Ser Cys Ser Ala Tyr Gly Val Arg Ala Pro His Pro Asp 
                725                 730                 735     


Gln Pro Glu Phe Thr Pro Val Gln Asp Glu Leu Glu Ala Met Glu Leu 
            740                 745                 750         


Trp Gly Pro Gly Val 
        755         


<210>  3234
<211>  1796
<212>  PRT
<213>  Homo Sapiens

<400>  3234

Met Lys Ile Phe Gln Arg Lys Met Arg Tyr Trp Leu Leu Pro Pro Phe 
1               5                   10                  15      


Leu Ala Ile Val Tyr Phe Cys Thr Ile Val Gln Gly Gln Val Ala Pro 
            20                  25                  30          


Pro Thr Arg Leu Arg Tyr Asn Val Ile Ser His Asp Ser Ile Gln Ile 
        35                  40                  45              


Ser Trp Lys Ala Pro Arg Gly Lys Phe Gly Gly Tyr Lys Leu Leu Val 
    50                  55                  60                  


Thr Pro Thr Ser Gly Gly Lys Thr Asn Gln Leu Asn Leu Gln Asn Thr 
65                  70                  75                  80  


Ala Thr Lys Ala Ile Ile Gln Gly Leu Met Pro Asp Gln Asn Tyr Thr 
                85                  90                  95      


Val Gln Ile Ile Ala Tyr Asn Lys Asp Lys Glu Ser Lys Pro Ala Gln 
            100                 105                 110         


Gly Gln Phe Arg Ile Lys Asp Leu Glu Lys Arg Lys Asp Pro Lys Pro 
        115                 120                 125             


Arg Val Lys Val Val Asp Arg Gly Asn Gly Ser Arg Pro Ser Ser Pro 
    130                 135                 140                 


Glu Glu Val Lys Phe Val Cys Gln Thr Pro Ala Ile Ala Asp Ile Val 
145                 150                 155                 160 


Ile Leu Val Asp Gly Ser Trp Ser Ile Gly Arg Phe Asn Phe Arg Leu 
                165                 170                 175     


Val Arg His Phe Leu Glu Asn Leu Val Thr Ala Phe Asp Val Gly Ser 
            180                 185                 190         


Glu Lys Thr Arg Ile Gly Leu Ala Gln Tyr Ser Gly Asp Pro Arg Ile 
        195                 200                 205             


Glu Trp His Leu Asn Ala Phe Ser Thr Lys Asp Glu Val Ile Glu Ala 
    210                 215                 220                 


Val Arg Asn Leu Pro Tyr Lys Gly Gly Asn Thr Leu Thr Gly Leu Ala 
225                 230                 235                 240 


Leu Asn Tyr Ile Phe Glu Asn Ser Phe Lys Pro Glu Ala Gly Ser Arg 
                245                 250                 255     


Thr Gly Val Ser Lys Ile Gly Ile Leu Ile Thr Asp Gly Lys Ser Gln 
            260                 265                 270         


Asp Asp Ile Ile Pro Pro Ser Arg Asn Leu Arg Glu Ser Gly Val Glu 
        275                 280                 285             


Leu Phe Ala Ile Gly Val Lys Asn Ala Asp Val Asn Glu Leu Gln Glu 
    290                 295                 300                 


Ile Ala Ser Glu Pro Asp Ser Thr His Val Tyr Asn Val Ala Glu Phe 
305                 310                 315                 320 


Asp Leu Met His Thr Val Val Glu Ser Leu Thr Arg Thr Leu Cys Ser 
                325                 330                 335     


Arg Val Glu Glu Gln Asp Arg Glu Ile Lys Ala Ser Ala His Ala Ile 
            340                 345                 350         


Thr Gly Pro Pro Thr Glu Leu Ile Thr Ser Glu Val Thr Ala Arg Ser 
        355                 360                 365             


Phe Met Val Asn Trp Thr His Ala Pro Gly Asn Val Glu Lys Tyr Arg 
    370                 375                 380                 


Val Val Tyr Tyr Pro Thr Arg Gly Gly Lys Pro Asp Glu Val Val Val 
385                 390                 395                 400 


Asp Gly Thr Val Ser Ser Thr Val Leu Lys Asn Leu Met Ser Leu Thr 
                405                 410                 415     


Glu Tyr Gln Ile Ala Val Phe Ala Ile Tyr Ala His Thr Ala Ser Glu 
            420                 425                 430         


Gly Leu Arg Gly Thr Glu Thr Thr Leu Ala Leu Pro Met Ala Ser Asp 
        435                 440                 445             


Leu Leu Leu Tyr Asp Val Thr Glu Asn Ser Met Arg Val Lys Trp Asp 
    450                 455                 460                 


Ala Val Pro Gly Ala Ser Gly Tyr Leu Ile Leu Tyr Ala Pro Leu Thr 
465                 470                 475                 480 


Glu Gly Leu Ala Gly Asp Glu Lys Glu Met Lys Ile Gly Glu Thr His 
                485                 490                 495     


Thr Asp Ile Glu Leu Ser Gly Leu Leu Pro Asn Thr Glu Tyr Thr Val 
            500                 505                 510         


Thr Val Tyr Ala Met Phe Gly Glu Glu Ala Ser Asp Pro Val Thr Gly 
        515                 520                 525             


Gln Glu Thr Thr Leu Ala Leu Ser Pro Pro Arg Asn Leu Arg Ile Ser 
    530                 535                 540                 


Asn Val Gly Ser Asn Ser Ala Arg Leu Thr Trp Asp Pro Thr Ser Arg 
545                 550                 555                 560 


Gln Ile Asn Gly Tyr Arg Ile Val Tyr Asn Asn Ala Asp Gly Thr Glu 
                565                 570                 575     


Ile Asn Glu Val Glu Val Asp Pro Ile Thr Thr Phe Pro Leu Lys Gly 
            580                 585                 590         


Leu Thr Pro Leu Thr Glu Tyr Thr Ile Ala Ile Phe Ser Ile Tyr Asp 
        595                 600                 605             


Glu Gly Gln Ser Glu Pro Leu Thr Gly Val Phe Thr Thr Glu Glu Val 
    610                 615                 620                 


Pro Ala Gln Gln Tyr Leu Glu Ile Asp Glu Val Thr Thr Asp Ser Phe 
625                 630                 635                 640 


Arg Val Thr Trp His Pro Leu Ser Ala Asp Glu Gly Leu His Lys Leu 
                645                 650                 655     


Met Trp Ile Pro Val Tyr Gly Gly Lys Thr Glu Glu Val Val Leu Lys 
            660                 665                 670         


Glu Glu Gln Asp Ser His Val Ile Glu Gly Leu Glu Pro Gly Thr Glu 
        675                 680                 685             


Tyr Glu Val Ser Leu Leu Ala Val Leu Asp Asp Gly Ser Glu Ser Glu 
    690                 695                 700                 


Val Val Thr Ala Val Gly Thr Thr Leu Asp Ser Phe Trp Thr Glu Pro 
705                 710                 715                 720 


Ala Thr Thr Ile Val Pro Thr Thr Ser Val Thr Ser Val Phe Gln Thr 
                725                 730                 735     


Gly Ile Arg Asn Leu Val Val Gly Asp Glu Thr Thr Ser Ser Leu Arg 
            740                 745                 750         


Val Lys Trp Asp Ile Ser Asp Ser Asp Val Gln Gln Phe Arg Val Thr 
        755                 760                 765             


Tyr Met Thr Ala Gln Gly Asp Pro Glu Glu Glu Val Ile Gly Thr Val 
    770                 775                 780                 


Met Val Pro Gly Ser Gln Asn Asn Leu Leu Leu Lys Pro Leu Leu Pro 
785                 790                 795                 800 


Asp Thr Glu Tyr Lys Val Thr Val Thr Pro Ile Tyr Thr Asp Gly Glu 
                805                 810                 815     


Gly Val Ser Val Ser Ala Pro Gly Lys Thr Leu Pro Ser Ser Gly Pro 
            820                 825                 830         


Gln Asn Leu Arg Val Ser Glu Glu Trp Tyr Asn Arg Leu Arg Ile Thr 
        835                 840                 845             


Trp Asp Pro Pro Ser Ser Pro Val Lys Gly Tyr Arg Ile Val Tyr Lys 
    850                 855                 860                 


Pro Val Ser Val Pro Gly Pro Thr Leu Glu Thr Phe Val Gly Ala Asp 
865                 870                 875                 880 


Ile Asn Thr Ile Leu Ile Thr Asn Leu Leu Ser Gly Met Asp Tyr Asn 
                885                 890                 895     


Val Lys Ile Phe Ala Ser Gln Ala Ser Gly Phe Ser Asp Ala Leu Thr 
            900                 905                 910         


Gly Met Val Lys Thr Leu Phe Leu Gly Val Thr Asn Leu Gln Ala Lys 
        915                 920                 925             


His Val Glu Met Thr Ser Leu Cys Ala His Trp Gln Val His Arg His 
    930                 935                 940                 


Ala Thr Ala Tyr Arg Val Val Ile Glu Ser Leu Gln Asp Arg Gln Lys 
945                 950                 955                 960 


Gln Glu Ser Thr Val Gly Gly Gly Thr Thr Arg His Cys Phe Tyr Gly 
                965                 970                 975     


Leu Gln Pro Asp Ser Glu Tyr Lys Ile Ser Val Tyr Thr Lys Leu Gln 
            980                 985                 990         


Glu Ile Glu Gly Pro Ser Val Ser  Ile Met Glu Lys Thr  Gln Ser Leu 
        995                 1000                 1005             


Pro Thr  Arg Pro Pro Thr Phe  Pro Pro Thr Ile Pro  Pro Ala Lys 
    1010                 1015                 1020             


Glu Val  Cys Lys Ala Ala Lys  Ala Asp Leu Val Phe  Met Val Asp 
    1025                 1030                 1035             


Gly Ser  Trp Ser Ile Gly Asp  Glu Asn Phe Asn Lys  Ile Ile Ser 
    1040                 1045                 1050             


Phe Leu  Tyr Ser Thr Val Gly  Ala Leu Asn Lys Ile  Gly Thr Asp 
    1055                 1060                 1065             


Gly Thr  Gln Val Ala Met Val  Gln Phe Thr Asp Asp  Pro Arg Thr 
    1070                 1075                 1080             


Glu Phe  Lys Leu Asn Ala Tyr  Lys Thr Lys Glu Thr  Leu Leu Asp 
    1085                 1090                 1095             


Ala Ile  Lys His Ile Ser Tyr  Lys Gly Gly Asn Thr  Lys Thr Gly 
    1100                 1105                 1110             


Lys Ala  Ile Lys Tyr Val Arg  Asp Thr Leu Phe Thr  Ala Glu Ser 
    1115                 1120                 1125             


Gly Thr  Arg Arg Gly Ile Pro  Lys Val Ile Val Val  Ile Thr Asp 
    1130                 1135                 1140             


Gly Arg  Ser Gln Asp Asp Val  Asn Lys Ile Ser Arg  Glu Met Gln 
    1145                 1150                 1155             


Leu Asp  Gly Tyr Ser Ile Phe  Ala Ile Gly Val Ala  Asp Ala Asp 
    1160                 1165                 1170             


Tyr Ser  Glu Leu Val Ser Ile  Gly Ser Lys Pro Ser  Ala Arg His 
    1175                 1180                 1185             


Val Phe  Phe Val Asp Asp Phe  Asp Ala Phe Lys Lys  Ile Glu Asp 
    1190                 1195                 1200             


Glu Leu  Ile Thr Phe Val Cys  Glu Thr Ala Ser Ala  Thr Cys Pro 
    1205                 1210                 1215             


Val Val  His Lys Asp Gly Ile  Asp Leu Ala Gly Phe  Lys Met Met 
    1220                 1225                 1230             


Glu Met  Phe Gly Leu Val Glu  Lys Asp Phe Ser Ser  Val Glu Gly 
    1235                 1240                 1245             


Val Ser  Met Glu Pro Gly Thr  Phe Asn Val Phe Pro  Cys Tyr Gln 
    1250                 1255                 1260             


Leu His  Lys Asp Ala Leu Val  Ser Gln Pro Thr Arg  Tyr Leu His 
    1265                 1270                 1275             


Pro Glu  Gly Leu Pro Ser Asp  Tyr Thr Ile Ser Phe  Leu Phe Arg 
    1280                 1285                 1290             


Ile Leu  Pro Asp Thr Pro Gln  Glu Pro Phe Ala Leu  Trp Glu Ile 
    1295                 1300                 1305             


Leu Asn  Lys Asn Ser Asp Pro  Leu Val Gly Val Ile  Leu Asp Asn 
    1310                 1315                 1320             


Gly Gly  Lys Thr Leu Thr Tyr  Phe Asn Tyr Asp Gln  Ser Gly Asp 
    1325                 1330                 1335             


Phe Gln  Thr Val Thr Phe Glu  Gly Pro Glu Ile Arg  Lys Ile Phe 
    1340                 1345                 1350             


Tyr Gly  Ser Phe His Lys Leu  His Ile Val Val Ser  Glu Thr Leu 
    1355                 1360                 1365             


Val Lys  Val Val Ile Asp Cys  Lys Gln Val Gly Glu  Lys Ala Met 
    1370                 1375                 1380             


Asn Ala  Ser Ala Asn Ile Thr  Ser Asp Gly Val Glu  Val Leu Gly 
    1385                 1390                 1395             


Lys Met  Val Arg Ser Arg Gly  Pro Gly Gly Asn Ser  Ala Pro Phe 
    1400                 1405                 1410             


Gln Leu  Gln Met Phe Asp Ile  Val Cys Ser Thr Ser  Trp Ala Asn 
    1415                 1420                 1425             


Thr Asp  Lys Cys Cys Glu Leu  Pro Gly Leu Arg Asp  Asp Glu Ser 
    1430                 1435                 1440             


Cys Pro  Asp Leu Pro His Ser  Cys Ser Cys Ser Glu  Thr Asn Glu 
    1445                 1450                 1455             


Val Ala  Leu Gly Pro Ala Gly  Pro Pro Gly Gly Pro  Gly Leu Arg 
    1460                 1465                 1470             


Gly Pro  Lys Gly Gln Gln Gly  Glu Pro Gly Pro Lys  Gly Pro Asp 
    1475                 1480                 1485             


Gly Pro  Arg Gly Glu Ile Gly  Leu Pro Gly Pro Gln  Gly Pro Pro 
    1490                 1495                 1500             


Gly Pro  Gln Gly Pro Ser Gly  Leu Ser Ile Gln Gly  Met Pro Gly 
    1505                 1510                 1515             


Met Pro  Gly Glu Lys Gly Glu  Lys Gly Asp Thr Gly  Leu Pro Gly 
    1520                 1525                 1530             


Pro Gln  Gly Ile Pro Gly Gly  Val Gly Ser Pro Gly  Arg Asp Gly 
    1535                 1540                 1545             


Ser Pro  Gly Gln Arg Gly Leu  Pro Gly Lys Asp Gly  Ser Ser Gly 
    1550                 1555                 1560             


Pro Pro  Gly Pro Pro Gly Pro  Ile Gly Ile Pro Gly  Thr Pro Gly 
    1565                 1570                 1575             


Val Pro  Gly Ile Thr Gly Ser  Met Gly Pro Gln Gly  Ala Leu Gly 
    1580                 1585                 1590             


Pro Pro  Gly Val Pro Gly Ala  Lys Gly Glu Arg Gly  Glu Arg Gly 
    1595                 1600                 1605             


Asp Leu  Gln Ser Gln Ala Met  Val Arg Ser Val Ala  Arg Gln Val 
    1610                 1615                 1620             


Cys Glu  Gln Leu Ile Gln Ser  His Met Ala Arg Tyr  Thr Ala Ile 
    1625                 1630                 1635             


Leu Asn  Gln Ile Pro Ser His  Ser Ser Ser Ile Arg  Thr Val Gln 
    1640                 1645                 1650             


Gly Pro  Pro Gly Glu Pro Gly  Arg Pro Gly Ser Pro  Gly Ala Pro 
    1655                 1660                 1665             


Gly Glu  Gln Gly Pro Pro Gly  Thr Pro Gly Phe Pro  Gly Asn Ala 
    1670                 1675                 1680             


Gly Val  Pro Gly Thr Pro Gly  Glu Arg Gly Leu Thr  Gly Ile Lys 
    1685                 1690                 1695             


Gly Glu  Lys Gly Asn Pro Gly  Val Gly Thr Gln Gly  Pro Arg Gly 
    1700                 1705                 1710             


Pro Pro  Gly Pro Ala Gly Pro  Ser Gly Glu Ser Arg  Pro Gly Ser 
    1715                 1720                 1725             


Pro Gly  Pro Pro Gly Ser Pro  Gly Pro Arg Gly Pro  Pro Gly His 
    1730                 1735                 1740             


Leu Gly  Val Pro Gly Pro Gln  Gly Pro Ser Gly Gln  Pro Gly Tyr 
    1745                 1750                 1755             


Cys Asp  Pro Ser Ser Cys Ser  Ala Tyr Gly Val Arg  Ala Pro His 
    1760                 1765                 1770             


Pro Asp  Gln Pro Glu Phe Thr  Pro Val Gln Asp Glu  Leu Glu Ala 
    1775                 1780                 1785             


Met Glu  Leu Trp Gly Pro Gly  Val 
    1790                 1795     


<210>  3235
<211>  1780
<212>  PRT
<213>  Homo Sapiens

<400>  3235

Met Lys Ile Phe Gln Arg Lys Met Arg Tyr Trp Leu Leu Pro Pro Phe 
1               5                   10                  15      


Leu Ala Ile Val Tyr Phe Cys Thr Ile Val Gln Gly Gln Val Ala Pro 
            20                  25                  30          


Pro Thr Arg Leu Arg Tyr Asn Val Ile Ser His Asp Ser Ile Gln Ile 
        35                  40                  45              


Ser Trp Lys Ala Pro Arg Gly Lys Phe Gly Gly Tyr Lys Leu Leu Val 
    50                  55                  60                  


Thr Pro Thr Ser Gly Gly Lys Thr Asn Gln Leu Asn Leu Gln Asn Thr 
65                  70                  75                  80  


Ala Thr Lys Ala Ile Ile Gln Gly Leu Met Pro Asp Gln Asn Tyr Thr 
                85                  90                  95      


Val Gln Ile Ile Ala Tyr Asn Lys Asp Lys Glu Ser Lys Pro Ala Gln 
            100                 105                 110         


Gly Gln Phe Arg Ile Lys Asp Leu Glu Lys Arg Lys Asp Pro Lys Pro 
        115                 120                 125             


Arg Val Lys Val Val Asp Arg Gly Asn Gly Ser Arg Pro Ser Ser Pro 
    130                 135                 140                 


Glu Glu Val Lys Phe Val Cys Gln Thr Pro Ala Ile Ala Asp Ile Val 
145                 150                 155                 160 


Ile Leu Val Asp Gly Ser Trp Ser Ile Gly Arg Phe Asn Phe Arg Leu 
                165                 170                 175     


Val Arg His Phe Leu Glu Asn Leu Val Thr Ala Phe Asp Val Gly Ser 
            180                 185                 190         


Glu Lys Thr Arg Ile Gly Leu Ala Gln Tyr Ser Gly Asp Pro Arg Ile 
        195                 200                 205             


Glu Trp His Leu Asn Ala Phe Ser Thr Lys Asp Glu Val Ile Glu Ala 
    210                 215                 220                 


Val Arg Asn Leu Pro Tyr Lys Gly Gly Asn Thr Leu Thr Gly Leu Ala 
225                 230                 235                 240 


Leu Asn Tyr Ile Phe Glu Asn Ser Phe Lys Pro Glu Ala Gly Ser Arg 
                245                 250                 255     


Thr Gly Val Ser Lys Ile Gly Ile Leu Ile Thr Asp Gly Lys Ser Gln 
            260                 265                 270         


Asp Asp Ile Ile Pro Pro Ser Arg Asn Leu Arg Glu Ser Gly Val Glu 
        275                 280                 285             


Leu Phe Ala Ile Gly Val Lys Asn Ala Asp Val Asn Glu Leu Gln Glu 
    290                 295                 300                 


Ile Ala Ser Glu Pro Asp Ser Thr His Val Tyr Asn Val Ala Glu Phe 
305                 310                 315                 320 


Asp Leu Met His Thr Val Val Glu Ser Leu Thr Arg Thr Leu Cys Ser 
                325                 330                 335     


Arg Val Glu Glu Gln Asp Arg Glu Ile Lys Ala Ser Ala His Ala Ile 
            340                 345                 350         


Thr Gly Pro Pro Thr Glu Leu Ile Thr Ser Glu Val Thr Ala Arg Ser 
        355                 360                 365             


Phe Met Val Asn Trp Thr His Ala Pro Gly Asn Val Glu Lys Tyr Arg 
    370                 375                 380                 


Val Val Tyr Tyr Pro Thr Arg Gly Gly Lys Pro Asp Glu Val Val Val 
385                 390                 395                 400 


Asp Gly Thr Val Ser Ser Thr Val Leu Lys Asn Leu Met Ser Leu Thr 
                405                 410                 415     


Glu Tyr Gln Ile Ala Val Phe Ala Ile Tyr Ala His Thr Ala Ser Glu 
            420                 425                 430         


Gly Leu Arg Gly Thr Glu Thr Thr Leu Ala Leu Pro Met Ala Ser Asp 
        435                 440                 445             


Leu Leu Leu Tyr Asp Val Thr Glu Asn Ser Met Arg Val Lys Trp Asp 
    450                 455                 460                 


Ala Val Pro Gly Ala Ser Gly Tyr Leu Ile Leu Tyr Ala Pro Leu Thr 
465                 470                 475                 480 


Glu Gly Leu Ala Gly Asp Glu Lys Glu Met Lys Ile Gly Glu Thr His 
                485                 490                 495     


Thr Asp Ile Glu Leu Ser Gly Leu Leu Pro Asn Thr Glu Tyr Thr Val 
            500                 505                 510         


Thr Val Tyr Ala Met Phe Gly Glu Glu Ala Ser Asp Pro Val Thr Gly 
        515                 520                 525             


Gln Glu Thr Thr Leu Ala Leu Ser Pro Pro Arg Asn Leu Arg Ile Ser 
    530                 535                 540                 


Asn Val Gly Ser Asn Ser Ala Arg Leu Thr Trp Asp Pro Thr Ser Arg 
545                 550                 555                 560 


Gln Ile Asn Gly Tyr Arg Ile Val Tyr Asn Asn Ala Asp Gly Thr Glu 
                565                 570                 575     


Ile Asn Glu Val Glu Val Asp Pro Ile Thr Thr Phe Pro Leu Lys Gly 
            580                 585                 590         


Leu Thr Pro Leu Thr Glu Tyr Thr Ile Ala Ile Phe Ser Ile Tyr Asp 
        595                 600                 605             


Glu Gly Gln Ser Glu Pro Leu Thr Gly Val Phe Thr Thr Glu Glu Val 
    610                 615                 620                 


Pro Ala Gln Gln Tyr Leu Glu Ile Asp Glu Val Thr Thr Asp Ser Phe 
625                 630                 635                 640 


Arg Val Thr Trp His Pro Leu Ser Ala Asp Glu Gly Leu His Lys Leu 
                645                 650                 655     


Met Trp Ile Pro Val Tyr Gly Gly Lys Thr Glu Glu Val Val Leu Lys 
            660                 665                 670         


Glu Glu Gln Asp Ser His Val Ile Glu Gly Leu Glu Pro Gly Thr Glu 
        675                 680                 685             


Tyr Glu Val Ser Leu Leu Ala Val Leu Asp Asp Gly Ser Glu Ser Glu 
    690                 695                 700                 


Val Val Thr Ala Val Gly Thr Thr Leu Asp Ser Phe Trp Thr Glu Pro 
705                 710                 715                 720 


Ala Thr Thr Ile Val Pro Thr Thr Ser Val Thr Ser Val Phe Gln Thr 
                725                 730                 735     


Gly Ile Arg Asn Leu Val Val Gly Asp Glu Thr Thr Ser Ser Leu Arg 
            740                 745                 750         


Val Lys Trp Asp Ile Ser Asp Ser Asp Val Gln Gln Phe Arg Val Thr 
        755                 760                 765             


Tyr Met Thr Ala Gln Gly Asp Pro Glu Glu Glu Val Ile Gly Thr Val 
    770                 775                 780                 


Met Val Pro Gly Ser Gln Asn Asn Leu Leu Leu Lys Pro Leu Leu Pro 
785                 790                 795                 800 


Asp Thr Glu Tyr Lys Val Thr Val Thr Pro Ile Tyr Thr Asp Gly Glu 
                805                 810                 815     


Gly Val Ser Val Ser Ala Pro Gly Lys Thr Leu Pro Ser Ser Gly Pro 
            820                 825                 830         


Gln Asn Leu Arg Val Ser Glu Glu Trp Tyr Asn Arg Leu Arg Ile Thr 
        835                 840                 845             


Trp Asp Pro Pro Ser Ser Pro Val Lys Gly Tyr Arg Ile Val Tyr Lys 
    850                 855                 860                 


Pro Val Ser Val Pro Gly Pro Thr Leu Glu Thr Phe Val Gly Ala Asp 
865                 870                 875                 880 


Ile Asn Thr Ile Leu Ile Thr Asn Leu Leu Ser Gly Met Asp Tyr Asn 
                885                 890                 895     


Val Lys Ile Phe Ala Ser Gln Ala Ser Gly Phe Ser Asp Ala Leu Thr 
            900                 905                 910         


Gly Met Val Lys Thr Leu Phe Leu Gly Val Thr Asn Leu Gln Ala Lys 
        915                 920                 925             


His Val Glu Met Thr Ser Leu Cys Ala His Trp Gln Val His Arg His 
    930                 935                 940                 


Ala Thr Ala Tyr Arg Val Val Ile Glu Ser Leu Gln Asp Arg Gln Lys 
945                 950                 955                 960 


Gln Glu Ser Thr Val Gly Gly Gly Thr Thr Arg His Cys Phe Tyr Gly 
                965                 970                 975     


Leu Gln Pro Asp Ser Glu Tyr Lys Ile Ser Val Tyr Thr Lys Leu Gln 
            980                 985                 990         


Glu Ile Glu Gly Pro Ser Val Ser  Ile Met Glu Lys Thr  Gln Ser Leu 
        995                 1000                 1005             


Pro Thr  Arg Pro Pro Thr Phe  Pro Pro Thr Ile Pro  Pro Ala Lys 
    1010                 1015                 1020             


Glu Val  Cys Lys Ala Ala Lys  Ala Asp Leu Val Phe  Met Val Asp 
    1025                 1030                 1035             


Gly Ser  Trp Ser Ile Gly Asp  Glu Asn Phe Asn Lys  Ile Ile Ser 
    1040                 1045                 1050             


Phe Leu  Tyr Ser Thr Val Gly  Ala Leu Asn Lys Ile  Gly Thr Asp 
    1055                 1060                 1065             


Gly Thr  Gln Val Ala Met Val  Gln Phe Thr Asp Asp  Pro Arg Thr 
    1070                 1075                 1080             


Glu Phe  Lys Leu Asn Ala Tyr  Lys Thr Lys Glu Thr  Leu Leu Asp 
    1085                 1090                 1095             


Ala Ile  Lys His Ile Ser Tyr  Lys Gly Gly Asn Thr  Lys Thr Gly 
    1100                 1105                 1110             


Lys Ala  Ile Lys Tyr Val Arg  Asp Thr Leu Phe Thr  Ala Glu Ser 
    1115                 1120                 1125             


Gly Thr  Arg Arg Gly Ile Pro  Lys Val Ile Val Val  Ile Thr Asp 
    1130                 1135                 1140             


Gly Arg  Ser Gln Asp Asp Val  Asn Lys Ile Ser Arg  Glu Met Gln 
    1145                 1150                 1155             


Leu Asp  Gly Tyr Ser Ile Phe  Ala Ile Gly Val Ala  Asp Ala Asp 
    1160                 1165                 1170             


Tyr Ser  Glu Leu Val Ser Ile  Gly Ser Lys Pro Ser  Ala Arg His 
    1175                 1180                 1185             


Val Phe  Phe Val Asp Asp Phe  Asp Ala Phe Lys Lys  Ile Glu Asp 
    1190                 1195                 1200             


Glu Leu  Ile Thr Phe Val Cys  Glu Thr Ala Ser Ala  Thr Cys Pro 
    1205                 1210                 1215             


Val Val  His Lys Asp Gly Ile  Asp Leu Ala Gly Phe  Lys Met Met 
    1220                 1225                 1230             


Glu Met  Phe Gly Leu Val Glu  Lys Asp Phe Ser Ser  Val Glu Gly 
    1235                 1240                 1245             


Val Ser  Met Glu Pro Gly Thr  Phe Asn Val Phe Pro  Cys Tyr Gln 
    1250                 1255                 1260             


Leu His  Lys Asp Ala Leu Val  Ser Gln Pro Thr Arg  Tyr Leu His 
    1265                 1270                 1275             


Pro Glu  Gly Leu Pro Ser Asp  Tyr Thr Ile Ser Phe  Leu Phe Arg 
    1280                 1285                 1290             


Ile Leu  Pro Asp Thr Pro Gln  Glu Pro Phe Ala Leu  Trp Glu Ile 
    1295                 1300                 1305             


Leu Asn  Lys Asn Ser Asp Pro  Leu Val Gly Val Ile  Leu Asp Asn 
    1310                 1315                 1320             


Gly Gly  Lys Thr Leu Thr Tyr  Phe Asn Tyr Asp Gln  Ser Gly Asp 
    1325                 1330                 1335             


Phe Gln  Thr Val Thr Phe Glu  Gly Pro Glu Ile Arg  Lys Ile Phe 
    1340                 1345                 1350             


Tyr Gly  Ser Phe His Lys Leu  His Ile Val Val Ser  Glu Thr Leu 
    1355                 1360                 1365             


Val Lys  Val Val Ile Asp Cys  Lys Gln Val Gly Glu  Lys Ala Met 
    1370                 1375                 1380             


Asn Ala  Ser Ala Asn Ile Thr  Ser Asp Gly Val Glu  Val Leu Gly 
    1385                 1390                 1395             


Lys Met  Val Arg Ser Arg Gly  Pro Gly Gly Asn Ser  Ala Pro Phe 
    1400                 1405                 1410             


Gln Leu  Gln Met Phe Asp Ile  Val Cys Ser Thr Ser  Trp Ala Asn 
    1415                 1420                 1425             


Thr Asp  Lys Cys Cys Glu Leu  Pro Gly Leu Arg Asp  Asp Glu Ser 
    1430                 1435                 1440             


Cys Pro  Asp Leu Pro His Ser  Cys Ser Cys Ser Glu  Thr Asn Glu 
    1445                 1450                 1455             


Val Ala  Leu Gly Pro Ala Gly  Pro Pro Gly Gly Pro  Gly Leu Arg 
    1460                 1465                 1470             


Gly Pro  Lys Gly Gln Gln Gly  Glu Pro Gly Pro Lys  Gly Pro Asp 
    1475                 1480                 1485             


Gly Pro  Arg Gly Glu Ile Gly  Leu Pro Gly Pro Gln  Gly Pro Pro 
    1490                 1495                 1500             


Gly Pro  Gln Gly Pro Ser Gly  Leu Ser Ile Gln Gly  Met Pro Gly 
    1505                 1510                 1515             


Met Pro  Gly Glu Lys Gly Glu  Lys Gly Asp Thr Gly  Leu Pro Gly 
    1520                 1525                 1530             


Pro Gln  Gly Ile Pro Gly Gly  Val Gly Ser Pro Gly  Arg Asp Gly 
    1535                 1540                 1545             


Ser Pro  Gly Gln Arg Gly Leu  Pro Gly Lys Asp Gly  Ser Ser Gly 
    1550                 1555                 1560             


Pro Pro  Gly Pro Pro Gly Pro  Ile Gly Ile Pro Gly  Thr Pro Gly 
    1565                 1570                 1575             


Val Pro  Gly Ile Thr Gly Ser  Met Gly Pro Gln Gly  Ala Leu Gly 
    1580                 1585                 1590             


Pro Pro  Gly Val Pro Gly Ala  Lys Gly Glu Arg Gly  Glu Arg Gly 
    1595                 1600                 1605             


Asp Leu  Gln Ser Gln Ala Met  Val Arg Ser Val Ala  Arg Gln Val 
    1610                 1615                 1620             


Cys Glu  Gln Leu Ile Gln Ser  His Met Ala Arg Tyr  Thr Ala Ile 
    1625                 1630                 1635             


Leu Asn  Gln Ile Pro Ser His  Ser Ser Ser Ile Arg  Thr Val Gln 
    1640                 1645                 1650             


Gly Pro  Pro Gly Glu Pro Gly  Arg Pro Gly Ser Pro  Gly Ala Pro 
    1655                 1660                 1665             


Gly Glu  Gln Gly Pro Pro Gly  Thr Pro Gly Phe Pro  Gly Asn Ala 
    1670                 1675                 1680             


Gly Val  Pro Gly Thr Pro Gly  Glu Arg Gly Leu Thr  Gly Ile Lys 
    1685                 1690                 1695             


Gly Glu  Lys Gly Asn Pro Gly  Val Gly Thr Gln Gly  Pro Arg Gly 
    1700                 1705                 1710             


Pro Pro  Gly Pro Ala Gly Pro  Ser Gly Glu Ser Arg  Pro Gly Ser 
    1715                 1720                 1725             


Pro Gly  Pro Pro Gly Ser Pro  Gly Pro Arg Gly Pro  Pro Gly His 
    1730                 1735                 1740             


Leu Gly  Val Pro Gly Pro Gln  Gly Pro Ser Gly Gln  Pro Gly Tyr 
    1745                 1750                 1755             


Cys Asp  Pro Ser Ser Cys Ser  Ala Tyr Gly Val Arg  Asp Leu Ile 
    1760                 1765                 1770             


Pro Tyr  Asn Asp Tyr Gln His  
    1775                 1780 


<210>  3236
<211>  534
<212>  PRT
<213>  Homo Sapiens

<400>  3236

Met Lys Ile Phe Gln Arg Lys Met Arg Tyr Trp Leu Leu Pro Pro Phe 
1               5                   10                  15      


Leu Ala Ile Val Tyr Phe Cys Thr Ile Val Gln Gly Gln Val Ala Pro 
            20                  25                  30          


Pro Thr Arg Leu Arg Tyr Asn Val Ile Ser His Asp Ser Ile Gln Ile 
        35                  40                  45              


Ser Trp Lys Ala Pro Arg Gly Lys Phe Gly Gly Tyr Lys Leu Leu Val 
    50                  55                  60                  


Thr Pro Thr Ser Gly Gly Lys Thr Asn Gln Leu Asn Leu Gln Asn Thr 
65                  70                  75                  80  


Ala Thr Lys Ala Ile Ile Gln Gly Leu Met Pro Asp Gln Asn Tyr Thr 
                85                  90                  95      


Val Gln Ile Ile Ala Tyr Asn Lys Asp Lys Glu Ser Lys Pro Ala Gln 
            100                 105                 110         


Gly Gln Phe Arg Ile Lys Asp Leu Glu Lys Arg Lys Asp Pro Lys Pro 
        115                 120                 125             


Arg Val Lys Val Val Asp Arg Gly Asn Gly Ser Arg Pro Ser Ser Pro 
    130                 135                 140                 


Glu Glu Val Lys Phe Val Cys Gln Thr Pro Ala Ile Ala Asp Ile Val 
145                 150                 155                 160 


Ile Leu Val Asp Gly Ser Trp Ser Ile Gly Arg Phe Asn Phe Arg Leu 
                165                 170                 175     


Val Arg His Phe Leu Glu Asn Leu Val Thr Ala Phe Asp Val Gly Ser 
            180                 185                 190         


Glu Lys Thr Arg Ile Gly Leu Ala Gln Tyr Ser Gly Asp Pro Arg Ile 
        195                 200                 205             


Glu Trp His Leu Asn Ala Phe Ser Thr Lys Asp Glu Val Ile Glu Ala 
    210                 215                 220                 


Val Arg Asn Leu Pro Tyr Lys Gly Gly Asn Thr Leu Thr Gly Leu Ala 
225                 230                 235                 240 


Leu Asn Tyr Ile Phe Glu Asn Ser Phe Lys Pro Glu Ala Gly Ser Arg 
                245                 250                 255     


Thr Gly Val Ser Lys Ile Gly Ile Leu Ile Thr Asp Gly Lys Ser Gln 
            260                 265                 270         


Asp Asp Ile Ile Pro Pro Ser Arg Asn Leu Arg Glu Ser Gly Val Glu 
        275                 280                 285             


Leu Phe Ala Ile Gly Val Lys Asn Ala Asp Val Asn Glu Leu Gln Glu 
    290                 295                 300                 


Ile Ala Ser Glu Pro Asp Ser Thr His Val Tyr Asn Val Ala Glu Phe 
305                 310                 315                 320 


Asp Leu Met His Thr Val Val Glu Ser Leu Thr Arg Thr Leu Cys Ser 
                325                 330                 335     


Arg Val Glu Glu Gln Asp Arg Glu Ile Lys Ala Ser Ala His Ala Ile 
            340                 345                 350         


Thr Gly Pro Pro Thr Glu Leu Ile Thr Ser Glu Val Thr Ala Arg Ser 
        355                 360                 365             


Phe Met Val Asn Trp Thr His Ala Pro Gly Asn Val Glu Lys Tyr Arg 
    370                 375                 380                 


Val Val Tyr Tyr Pro Thr Arg Gly Gly Lys Pro Asp Glu Val Val Val 
385                 390                 395                 400 


Asp Gly Thr Val Ser Ser Thr Val Leu Lys Asn Leu Met Ser Leu Thr 
                405                 410                 415     


Glu Tyr Gln Ile Ala Val Phe Ala Ile Tyr Ala His Thr Ala Ser Glu 
            420                 425                 430         


Gly Leu Arg Gly Thr Glu Thr Thr Leu Ala Leu Pro Met Ala Ser Asp 
        435                 440                 445             


Leu Leu Leu Tyr Asp Val Thr Glu Asn Ser Met Arg Val Lys Trp Asp 
    450                 455                 460                 


Ala Val Pro Gly Ala Ser Gly Tyr Leu Ile Leu Tyr Ala Pro Leu Thr 
465                 470                 475                 480 


Glu Gly Leu Ala Gly Asp Glu Lys Glu Met Lys Ile Gly Glu Thr His 
                485                 490                 495     


Thr Asp Ile Glu Leu Ser Gly Leu Leu Pro Asn Thr Glu Tyr Thr Val 
            500                 505                 510         


Thr Val Tyr Ala Met Phe Gly Glu Glu Ala Ser Asp Pro Val Thr Gly 
        515                 520                 525             


Gln Glu Thr Thr Ser Pro 
    530                 


<210>  3237
<211>  534
<212>  PRT
<213>  Homo Sapiens

<400>  3237

Met Lys Ile Phe Gln Arg Lys Met Arg Tyr Trp Leu Leu Pro Pro Phe 
1               5                   10                  15      


Leu Ala Ile Val Tyr Phe Cys Thr Ile Val Gln Gly Gln Val Ala Pro 
            20                  25                  30          


Pro Thr Arg Leu Arg Tyr Asn Val Ile Ser His Asp Ser Ile Gln Ile 
        35                  40                  45              


Ser Trp Lys Ala Pro Arg Gly Lys Phe Gly Gly Tyr Lys Leu Leu Val 
    50                  55                  60                  


Thr Pro Thr Ser Gly Gly Lys Thr Asn Gln Leu Asn Leu Gln Asn Thr 
65                  70                  75                  80  


Ala Thr Lys Ala Ile Ile Gln Gly Leu Met Pro Asp Gln Asn Tyr Thr 
                85                  90                  95      


Val Gln Ile Ile Ala Tyr Asn Lys Asp Lys Glu Ser Lys Pro Ala Gln 
            100                 105                 110         


Gly Gln Phe Arg Ile Lys Asp Leu Glu Lys Arg Lys Asp Pro Lys Pro 
        115                 120                 125             


Arg Val Lys Val Val Asp Arg Gly Asn Gly Ser Arg Pro Ser Ser Pro 
    130                 135                 140                 


Glu Glu Val Lys Phe Val Cys Gln Thr Pro Ala Ile Ala Asp Ile Val 
145                 150                 155                 160 


Ile Leu Val Asp Gly Ser Trp Ser Ile Gly Arg Phe Asn Phe Arg Leu 
                165                 170                 175     


Val Arg His Phe Leu Glu Asn Leu Val Thr Ala Phe Asp Val Gly Ser 
            180                 185                 190         


Glu Lys Thr Arg Ile Gly Leu Ala Gln Tyr Ser Gly Asp Pro Arg Ile 
        195                 200                 205             


Glu Trp His Leu Asn Ala Phe Ser Thr Lys Asp Glu Val Ile Glu Ala 
    210                 215                 220                 


Val Arg Asn Leu Pro Tyr Lys Gly Gly Asn Thr Leu Thr Gly Leu Ala 
225                 230                 235                 240 


Leu Asn Tyr Ile Phe Glu Asn Ser Phe Lys Pro Glu Ala Gly Ser Arg 
                245                 250                 255     


Thr Gly Val Ser Lys Ile Gly Ile Leu Ile Thr Asp Gly Lys Ser Gln 
            260                 265                 270         


Asp Asp Ile Ile Pro Pro Ser Arg Asn Leu Arg Glu Ser Gly Val Glu 
        275                 280                 285             


Leu Phe Ala Ile Gly Val Lys Asn Ala Asp Val Asn Glu Leu Gln Glu 
    290                 295                 300                 


Ile Ala Ser Glu Pro Asp Ser Thr His Val Tyr Asn Val Ala Glu Phe 
305                 310                 315                 320 


Asp Leu Met His Thr Val Val Glu Ser Leu Thr Arg Thr Leu Cys Ser 
                325                 330                 335     


Arg Val Glu Glu Gln Asp Arg Glu Ile Lys Ala Ser Ala His Ala Ile 
            340                 345                 350         


Thr Gly Pro Pro Thr Glu Leu Ile Thr Ser Glu Val Thr Ala Arg Ser 
        355                 360                 365             


Phe Met Val Asn Trp Thr His Ala Pro Gly Asn Val Glu Lys Tyr Arg 
    370                 375                 380                 


Val Val Tyr Tyr Pro Thr Arg Gly Gly Lys Pro Asp Glu Val Val Val 
385                 390                 395                 400 


Asp Gly Thr Val Ser Ser Thr Val Leu Lys Asn Leu Met Ser Leu Thr 
                405                 410                 415     


Glu Tyr Gln Ile Ala Val Phe Ala Ile Tyr Ala His Thr Ala Ser Glu 
            420                 425                 430         


Gly Leu Arg Gly Thr Glu Thr Thr Leu Ala Leu Pro Met Ala Ser Asp 
        435                 440                 445             


Leu Leu Leu Tyr Asp Val Thr Glu Asn Ser Met Arg Val Lys Trp Asp 
    450                 455                 460                 


Ala Val Pro Gly Ala Ser Gly Tyr Leu Ile Leu Tyr Ala Pro Leu Thr 
465                 470                 475                 480 


Glu Gly Leu Ala Gly Asp Glu Lys Glu Met Lys Ile Gly Glu Thr His 
                485                 490                 495     


Thr Asp Ile Glu Leu Ser Gly Leu Leu Pro Asn Thr Glu Tyr Thr Val 
            500                 505                 510         


Thr Val Tyr Ala Met Phe Gly Glu Glu Ala Ser Asp Pro Val Thr Gly 
        515                 520                 525             


Gln Glu Thr Thr Ser Pro 
    530                 


<210>  3238
<211>  337
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3238

Xaa Val Cys Gln Thr Pro Ala Ile Ala Asp Ile Val Ile Leu Val Asp 
1               5                   10                  15      


Gly Ser Trp Ser Ile Gly Arg Phe Asn Phe Arg Leu Val Arg His Phe 
            20                  25                  30          


Leu Glu Asn Leu Val Thr Ala Phe Asp Val Gly Ser Glu Lys Thr Arg 
        35                  40                  45              


Ile Gly Val Lys Asn Ala Asp Val Asn Glu Leu Gln Glu Ile Ala Ser 
    50                  55                  60                  


Glu Pro Asp Ser Thr His Val Tyr Asn Val Ala Glu Phe Asp Leu Met 
65                  70                  75                  80  


His Thr Val Val Glu Ser Leu Thr Arg Thr Leu Cys Ser Arg Val Glu 
                85                  90                  95      


Glu Gln Asp Arg Glu Ile Lys Ala Ser Ala His Ala Ile Thr Gly Pro 
            100                 105                 110         


Pro Thr Glu Leu Ile Thr Ser Glu Val Thr Ala Arg Ser Phe Met Val 
        115                 120                 125             


Asn Trp Thr His Ala Pro Gly Asn Val Glu Lys Tyr Arg Val Val Tyr 
    130                 135                 140                 


Tyr Pro Thr Arg Gly Gly Lys Pro Asp Glu Val Val Val Asp Gly Thr 
145                 150                 155                 160 


Val Ser Ser Thr Val Leu Lys Asn Leu Met Ser Leu Thr Glu Tyr Gln 
                165                 170                 175     


Ile Ala Val Phe Ala Ile Tyr Ala His Thr Ala Ser Glu Gly Leu Arg 
            180                 185                 190         


Gly Thr Glu Thr Thr Leu Ala Leu Pro Met Ala Ser Asp Leu Leu Leu 
        195                 200                 205             


Tyr Asp Val Thr Glu Asn Ser Met Arg Val Lys Trp Asp Ala Val Pro 
    210                 215                 220                 


Gly Ala Ser Gly Tyr Leu Ile Leu Tyr Ala Pro Leu Thr Glu Gly Leu 
225                 230                 235                 240 


Ala Gly Asp Glu Lys Glu Met Lys Ile Gly Glu Thr His Thr Asp Ile 
                245                 250                 255     


Glu Leu Ser Gly Leu Leu Pro Asn Thr Glu Tyr Thr Val Thr Val Tyr 
            260                 265                 270         


Ala Met Phe Gly Glu Glu Ala Ser Asp Pro Val Thr Gly Gln Glu Thr 
        275                 280                 285             


Thr Leu Ala Leu Ser Pro Pro Arg Asn Leu Arg Ile Ser Asn Val Gly 
    290                 295                 300                 


Ser Asn Ser Ala Arg Leu Thr Trp Asp Pro Thr Ser Arg Gln Ile Asn 
305                 310                 315                 320 


Gly Tyr Arg Ile Val Tyr Asn Asn Ala Asp Gly Thr Glu Ile Asn Glu 
                325                 330                 335     


Val 
    


<210>  3239
<211>  1388
<212>  PRT
<213>  Homo Sapiens

<400>  3239

Met Ala Pro Arg Arg Asn Asn Gly Gln Cys Trp Cys Leu Leu Met Leu 
1               5                   10                  15      


Leu Ser Val Ser Thr Pro Leu Pro Ala Val Thr Gln Thr Arg Gly Ala 
            20                  25                  30          


Thr Glu Thr Ala Ser Gln Gly His Leu Asp Leu Thr Gln Leu Ile Gly 
        35                  40                  45              


Val Pro Leu Pro Ser Ser Val Ser Phe Val Thr Gly Tyr Gly Gly Phe 
    50                  55                  60                  


Pro Ala Tyr Ser Phe Gly Pro Gly Ala Asn Val Gly Arg Pro Ala Arg 
65                  70                  75                  80  


Thr Leu Ile Pro Ser Thr Phe Phe Arg Asp Phe Ala Ile Ser Val Val 
                85                  90                  95      


Val Lys Pro Ser Ser Thr Arg Gly Gly Val Leu Phe Ala Ile Thr Asp 
            100                 105                 110         


Ala Phe Gln Lys Val Ile Tyr Leu Gly Leu Arg Leu Ser Gly Val Glu 
        115                 120                 125             


Asp Gly His Gln Arg Ile Ile Leu Tyr Tyr Thr Glu Pro Gly Ser His 
    130                 135                 140                 


Val Ser Gln Glu Ala Ala Ala Phe Ser Val Pro Val Met Thr His Arg 
145                 150                 155                 160 


Trp Asn Arg Phe Ala Met Ile Val Gln Gly Glu Glu Val Thr Leu Leu 
                165                 170                 175     


Val Asn Cys Glu Glu His Ser Arg Ile Pro Phe Gln Arg Ser Ser Gln 
            180                 185                 190         


Ala Leu Ala Phe Glu Ser Ser Ala Gly Ile Phe Met Gly Asn Ala Gly 
        195                 200                 205             


Ala Thr Gly Leu Glu Arg Phe Thr Gly Ser Leu Gln Gln Leu Thr Val 
    210                 215                 220                 


His Pro Asp Pro Arg Thr Pro Glu Glu Leu Cys Asp Pro Glu Glu Ser 
225                 230                 235                 240 


Ser Ala Ser Gly Glu Thr Ser Gly Leu Gln Glu Ala Asp Gly Val Ala 
                245                 250                 255     


Glu Ile Leu Glu Ala Val Thr Tyr Thr Gln Ala Ser Pro Lys Glu Ala 
            260                 265                 270         


Lys Val Glu Pro Ile Asn Thr Pro Pro Thr Pro Ser Ser Pro Phe Glu 
        275                 280                 285             


Asp Met Glu Leu Ser Gly Glu Pro Val Pro Glu Gly Thr Leu Glu Thr 
    290                 295                 300                 


Thr Asn Met Ser Ile Ile Gln His Ser Ser Pro Lys Gln Gly Ser Gly 
305                 310                 315                 320 


Glu Ile Leu Asn Asp Thr Leu Glu Gly Val His Ser Val Asp Gly Asp 
                325                 330                 335     


Pro Ile Thr Asp Ser Gly Ser Gly Ala Gly Ala Phe Leu Asp Ile Ala 
            340                 345                 350         


Glu Glu Lys Asn Leu Ala Ala Thr Ala Ala Gly Leu Ala Glu Val Pro 
        355                 360                 365             


Ile Ser Thr Ala Gly Glu Ala Glu Ala Ser Ser Val Pro Thr Gly Gly 
    370                 375                 380                 


Pro Thr Leu Ser Met Ser Thr Glu Asn Pro Glu Glu Gly Val Thr Pro 
385                 390                 395                 400 


Gly Pro Asp Asn Glu Glu Arg Leu Ala Ala Thr Ala Ala Gly Glu Ala 
                405                 410                 415     


Glu Ala Leu Ala Ser Met Pro Gly Glu Val Glu Ala Ser Gly Val Ala 
            420                 425                 430         


Pro Gly Glu Leu Asp Leu Ser Met Ser Ala Gln Ser Leu Gly Glu Glu 
        435                 440                 445             


Ala Thr Val Gly Pro Ser Ser Glu Asp Ser Leu Thr Thr Ala Ala Ala 
    450                 455                 460                 


Ala Thr Glu Val Ser Leu Ser Thr Phe Glu Asp Glu Glu Ala Ser Gly 
465                 470                 475                 480 


Val Pro Thr Asp Gly Leu Ala Pro Leu Thr Ala Thr Met Ala Pro Glu 
                485                 490                 495     


Arg Ala Val Thr Ser Gly Pro Gly Asp Glu Glu Asp Leu Ala Ala Ala 
            500                 505                 510         


Thr Thr Glu Glu Pro Leu Ile Thr Ala Gly Gly Glu Glu Ser Gly Ser 
        515                 520                 525             


Pro Pro Pro Asp Gly Pro Pro Leu Pro Leu Pro Thr Val Ala Pro Glu 
    530                 535                 540                 


Arg Trp Ile Thr Pro Ala Gln Arg Glu His Val Gly Met Lys Gly Gln 
545                 550                 555                 560 


Ala Gly Pro Lys Gly Glu Lys Gly Asp Ala Gly Glu Glu Leu Pro Gly 
                565                 570                 575     


Pro Pro Glu Pro Ser Gly Pro Val Gly Pro Thr Ala Gly Ala Glu Ala 
            580                 585                 590         


Glu Gly Ser Gly Leu Gly Trp Gly Ser Asp Val Gly Ser Gly Ser Gly 
        595                 600                 605             


Asp Leu Val Gly Ser Glu Gln Leu Leu Arg Gly Pro Pro Gly Pro Pro 
    610                 615                 620                 


Gly Pro Pro Gly Leu Pro Gly Ile Pro Gly Lys Pro Gly Thr Asp Val 
625                 630                 635                 640 


Phe Met Gly Pro Pro Gly Ser Pro Gly Glu Asp Gly Pro Ala Gly Glu 
                645                 650                 655     


Pro Gly Pro Pro Gly Pro Glu Gly Gln Pro Gly Val Asp Gly Ala Thr 
            660                 665                 670         


Gly Leu Pro Gly Met Lys Gly Glu Lys Gly Ala Arg Gly Pro Asn Gly 
        675                 680                 685             


Ser Val Gly Glu Lys Gly Asp Pro Gly Asn Arg Gly Leu Pro Gly Pro 
    690                 695                 700                 


Pro Gly Lys Lys Gly Gln Ala Gly Pro Pro Gly Val Met Gly Pro Pro 
705                 710                 715                 720 


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Gly Cys Thr Met Gly 
                725                 730                 735     


Leu Gly Phe Glu Asp Thr Glu Gly Ser Gly Ser Thr Gln Leu Leu Asn 
            740                 745                 750         


Glu Pro Lys Leu Ser Arg Pro Thr Ala Ala Ile Gly Leu Lys Gly Glu 
        755                 760                 765             


Lys Gly Asp Arg Gly Pro Lys Gly Glu Arg Gly Met Asp Gly Ala Ser 
    770                 775                 780                 


Ile Val Gly Pro Pro Gly Pro Arg Gly Pro Pro Gly His Ile Lys Val 
785                 790                 795                 800 


Leu Ser Asn Ser Leu Ile Asn Ile Thr His Gly Phe Met Asn Phe Ser 
                805                 810                 815     


Asp Ile Pro Glu Leu Val Gly Pro Pro Gly Pro Asp Gly Leu Pro Gly 
            820                 825                 830         


Leu Pro Gly Phe Pro Gly Pro Arg Gly Pro Lys Gly Asp Thr Gly Leu 
        835                 840                 845             


Pro Gly Phe Pro Gly Leu Lys Gly Glu Gln Gly Glu Lys Gly Glu Pro 
    850                 855                 860                 


Gly Ala Ile Leu Thr Glu Asp Ile Pro Leu Glu Arg Leu Met Gly Lys 
865                 870                 875                 880 


Lys Gly Glu Pro Gly Met His Gly Ala Pro Gly Pro Met Gly Pro Lys 
                885                 890                 895     


Gly Pro Pro Gly His Lys Gly Glu Phe Gly Leu Pro Gly Arg Pro Gly 
            900                 905                 910         


Arg Pro Gly Leu Asn Gly Leu Lys Gly Thr Lys Gly Asp Pro Gly Val 
        915                 920                 925             


Ile Met Gln Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly 
    930                 935                 940                 


Pro Pro Gly Ala Val Ile Asn Ile Lys Gly Ala Ile Phe Pro Ile Pro 
945                 950                 955                 960 


Val Arg Pro His Cys Lys Met Pro Val Asp Thr Ala His Pro Gly Ser 
                965                 970                 975     


Pro Glu Leu Ile Thr Phe His Gly Val Lys Gly Glu Lys Gly Ser Trp 
            980                 985                 990         


Gly Leu Pro Gly Ser Lys Gly Glu  Lys Gly Asp Gln Gly  Ala Gln Gly 
        995                 1000                 1005             


Pro Pro  Gly Pro Pro Leu Asp  Leu Ala Tyr Leu Arg  His Phe Leu 
    1010                 1015                 1020             


Asn Asn  Leu Lys Gly Glu Asn  Gly Asp Lys Gly Phe  Lys Gly Glu 
    1025                 1030                 1035             


Lys Gly  Glu Lys Gly Asp Ile  Asn Gly Ser Phe Leu  Met Ser Gly 
    1040                 1045                 1050             


Pro Pro  Gly Leu Pro Gly Asn  Pro Gly Pro Ala Gly  Gln Lys Gly 
    1055                 1060                 1065             


Glu Thr  Val Val Gly Pro Gln  Gly Pro Pro Gly Ala  Pro Gly Leu 
    1070                 1075                 1080             


Pro Gly  Pro Pro Gly Phe Gly  Arg Pro Gly Asp Pro  Gly Pro Pro 
    1085                 1090                 1095             


Gly Pro  Pro Gly Pro Pro Gly  Pro Pro Ala Ile Leu  Gly Ala Ala 
    1100                 1105                 1110             


Val Ala  Leu Pro Gly Pro Pro  Gly Pro Pro Gly Gln  Pro Gly Leu 
    1115                 1120                 1125             


Pro Gly  Ser Arg Asn Leu Val  Thr Ala Phe Ser Asn  Met Asp Asp 
    1130                 1135                 1140             


Met Leu  Gln Lys Ala His Leu  Val Ile Glu Gly Thr  Phe Ile Tyr 
    1145                 1150                 1155             


Leu Arg  Asp Ser Thr Glu Phe  Phe Ile Arg Val Arg  Asp Gly Trp 
    1160                 1165                 1170             


Lys Lys  Leu Gln Leu Gly Glu  Leu Ile Pro Ile Pro  Ala Asp Ser 
    1175                 1180                 1185             


Pro Pro  Pro Pro Ala Leu Ser  Ser Asn Pro His Gln  Leu Leu Pro 
    1190                 1195                 1200             


Pro Pro  Asn Pro Ile Ser Ser  Ala Asn Tyr Glu Lys  Pro Ala Leu 
    1205                 1210                 1215             


His Leu  Ala Ala Leu Asn Met  Pro Phe Ser Gly Asp  Ile Arg Ala 
    1220                 1225                 1230             


Asp Phe  Gln Cys Phe Lys Gln  Ala Arg Ala Ala Gly  Leu Leu Ser 
    1235                 1240                 1245             


Thr Tyr  Arg Ala Phe Leu Ser  Ser His Leu Gln Asp  Leu Ser Thr 
    1250                 1255                 1260             


Ile Val  Arg Lys Ala Glu Arg  Tyr Ser Leu Pro Ile  Val Asn Leu 
    1265                 1270                 1275             


Lys Gly  Gln Val Leu Phe Asn  Asn Trp Asp Ser Ile  Phe Ser Gly 
    1280                 1285                 1290             


His Gly  Gly Gln Phe Asn Met  His Ile Pro Ile Tyr  Ser Phe Asp 
    1295                 1300                 1305             


Gly Arg  Asp Ile Met Thr Asp  Pro Ser Trp Pro Gln  Lys Val Ile 
    1310                 1315                 1320             


Trp His  Gly Ser Ser Pro His  Gly Val Arg Leu Val  Asp Asn Tyr 
    1325                 1330                 1335             


Cys Glu  Ala Trp Arg Thr Ala  Asp Thr Ala Val Thr  Gly Leu Ala 
    1340                 1345                 1350             


Ser Pro  Leu Ser Thr Gly Lys  Ile Leu Asp Gln Lys  Ala Tyr Ser 
    1355                 1360                 1365             


Cys Ala  Asn Arg Leu Ile Val  Leu Cys Ile Glu Asn  Ser Phe Met 
    1370                 1375                 1380             


Thr Asp  Ala Arg Lys 
    1385             


<210>  3240
<211>  1374
<212>  PRT
<213>  Homo Sapiens

<400>  3240

Met Leu Leu Ser Val Ser Thr Pro Leu Pro Ala Val Thr Gln Thr Arg 
1               5                   10                  15      


Gly Ala Thr Glu Thr Ala Ser Gln Gly His Leu Asp Leu Thr Gln Leu 
            20                  25                  30          


Ile Gly Val Pro Leu Pro Ser Ser Val Ser Phe Val Thr Gly Tyr Gly 
        35                  40                  45              


Gly Phe Pro Ala Tyr Ser Phe Gly Pro Gly Ala Asn Val Gly Arg Pro 
    50                  55                  60                  


Ala Arg Thr Leu Ile Pro Ser Thr Phe Phe Arg Asp Phe Ala Ile Ser 
65                  70                  75                  80  


Val Val Val Lys Pro Ser Ser Thr Arg Gly Gly Val Leu Phe Ala Ile 
                85                  90                  95      


Thr Asp Ala Phe Gln Lys Val Ile Tyr Leu Gly Leu Arg Leu Ser Gly 
            100                 105                 110         


Val Glu Asp Gly His Gln Arg Ile Ile Leu Tyr Tyr Thr Glu Pro Gly 
        115                 120                 125             


Ser His Val Ser Gln Glu Ala Ala Ala Phe Ser Val Pro Val Met Thr 
    130                 135                 140                 


His Arg Trp Asn Arg Phe Ala Met Ile Val Gln Gly Glu Glu Val Thr 
145                 150                 155                 160 


Leu Leu Val Asn Cys Glu Glu His Ser Arg Ile Pro Phe Gln Arg Ser 
                165                 170                 175     


Ser Gln Ala Leu Ala Phe Glu Ser Ser Ala Gly Ile Phe Met Gly Asn 
            180                 185                 190         


Ala Gly Ala Thr Gly Leu Glu Arg Phe Thr Gly Ser Leu Gln Gln Leu 
        195                 200                 205             


Thr Val His Pro Asp Pro Arg Thr Pro Glu Glu Leu Cys Asp Pro Glu 
    210                 215                 220                 


Glu Ser Ser Ala Ser Gly Glu Thr Ser Gly Leu Gln Glu Ala Asp Gly 
225                 230                 235                 240 


Val Ala Glu Ile Leu Glu Ala Val Thr Tyr Thr Gln Ala Ser Pro Lys 
                245                 250                 255     


Glu Ala Lys Val Glu Pro Ile Asn Thr Pro Pro Thr Pro Ser Ser Pro 
            260                 265                 270         


Phe Glu Asp Met Glu Leu Ser Gly Glu Pro Val Pro Glu Gly Thr Leu 
        275                 280                 285             


Glu Thr Thr Asn Met Ser Ile Ile Gln His Ser Ser Pro Lys Gln Gly 
    290                 295                 300                 


Lys Gly Ala Ile Leu Asn Asp Thr Leu Glu Gly Val His Ser Val Asp 
305                 310                 315                 320 


Gly Asp Pro Ile Thr Asp Ser Gly Ser Gly Ala Gly Ala Phe Leu Asp 
                325                 330                 335     


Ile Ala Glu Glu Lys Asn Leu Ala Ala Thr Ala Ala Gly Leu Ala Glu 
            340                 345                 350         


Val Pro Ile Ser Thr Ala Gly Glu Ala Glu Ala Ser Ser Val Pro Thr 
        355                 360                 365             


Gly Gly Pro Thr Leu Ser Met Ser Thr Glu Asn Pro Glu Glu Gly Val 
    370                 375                 380                 


Thr Pro Gly Pro Asp Asn Glu Glu Arg Leu Ala Ala Thr Ala Ala Gly 
385                 390                 395                 400 


Glu Ala Glu Ala Leu Ala Ser Met Pro Gly Glu Val Glu Ala Ser Gly 
                405                 410                 415     


Val Ala Pro Gly Glu Leu Asp Leu Ser Met Ser Ala Gln Ser Leu Gly 
            420                 425                 430         


Glu Glu Ala Thr Val Gly Pro Ser Ser Glu Asp Ser Leu Thr Thr Ala 
        435                 440                 445             


Ala Ala Ala Thr Glu Val Ser Leu Ser Thr Phe Glu Asp Glu Glu Ala 
    450                 455                 460                 


Ser Gly Val Pro Thr Asp Gly Leu Ala Pro Leu Thr Ala Thr Met Ala 
465                 470                 475                 480 


Pro Glu Arg Ala Val Thr Ser Gly Pro Gly Asp Glu Glu Asp Leu Ala 
                485                 490                 495     


Ala Ala Thr Thr Glu Glu Pro Leu Ile Thr Ala Gly Gly Glu Glu Ser 
            500                 505                 510         


Gly Ser Pro Pro Pro Asp Gly Pro Pro Leu Pro Leu Pro Thr Val Ala 
        515                 520                 525             


Pro Glu Arg Trp Ile Thr Pro Ala Gln Arg Glu His Val Gly Met Lys 
    530                 535                 540                 


Gly Gln Ala Gly Pro Lys Gly Glu Lys Gly Asp Ala Gly Glu Glu Leu 
545                 550                 555                 560 


Pro Gly Pro Pro Glu Pro Ser Gly Pro Val Gly Pro Thr Ala Gly Ala 
                565                 570                 575     


Glu Ala Glu Gly Ser Gly Leu Gly Trp Gly Ser Asp Val Gly Ser Gly 
            580                 585                 590         


Ser Gly Asp Leu Val Gly Ser Glu Gln Leu Leu Arg Gly Pro Pro Gly 
        595                 600                 605             


Pro Pro Gly Pro Pro Gly Leu Pro Gly Ile Pro Gly Lys Pro Gly Thr 
    610                 615                 620                 


Asp Val Phe Met Gly Pro Pro Gly Ser Pro Gly Glu Asp Gly Pro Ala 
625                 630                 635                 640 


Gly Glu Pro Gly Pro Pro Gly Pro Glu Gly Gln Pro Gly Val Asp Gly 
                645                 650                 655     


Ala Thr Gly Leu Pro Gly Met Lys Gly Glu Lys Gly Ala Arg Gly Pro 
            660                 665                 670         


Asn Gly Ser Val Gly Glu Lys Gly Asp Pro Gly Asn Arg Gly Leu Pro 
        675                 680                 685             


Gly Pro Pro Gly Lys Lys Gly Gln Ala Gly Pro Pro Gly Val Met Gly 
    690                 695                 700                 


Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Gly Cys Thr 
705                 710                 715                 720 


Met Gly Leu Gly Phe Glu Asp Thr Glu Gly Ser Gly Ser Thr Gln Leu 
                725                 730                 735     


Leu Asn Glu Pro Lys Leu Ser Arg Pro Thr Ala Ala Ile Gly Leu Lys 
            740                 745                 750         


Gly Glu Lys Gly Asp Arg Gly Pro Lys Gly Glu Arg Gly Met Asp Gly 
        755                 760                 765             


Ala Ser Ile Val Gly Pro Pro Gly Pro Arg Gly Pro Pro Gly His Ile 
    770                 775                 780                 


Lys Val Leu Ser Asn Ser Leu Ile Asn Ile Thr His Gly Phe Met Asn 
785                 790                 795                 800 


Phe Ser Asp Ile Pro Glu Leu Val Gly Pro Pro Gly Pro Asp Gly Leu 
                805                 810                 815     


Pro Gly Leu Pro Gly Phe Pro Gly Pro Arg Gly Pro Lys Gly Asp Thr 
            820                 825                 830         


Gly Leu Pro Gly Phe Pro Gly Leu Lys Gly Glu Gln Gly Glu Lys Gly 
        835                 840                 845             


Glu Pro Gly Ala Ile Leu Thr Glu Asp Ile Pro Leu Glu Arg Leu Met 
    850                 855                 860                 


Gly Lys Lys Gly Glu Pro Gly Met His Gly Ala Pro Gly Pro Met Gly 
865                 870                 875                 880 


Pro Lys Gly Pro Pro Gly His Lys Gly Glu Phe Gly Leu Pro Gly Arg 
                885                 890                 895     


Pro Gly Arg Pro Gly Leu Asn Gly Leu Lys Gly Thr Lys Gly Asp Pro 
            900                 905                 910         


Gly Val Ile Met Gln Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro 
        915                 920                 925             


Pro Gly Pro Pro Gly Ala Val Ile Asn Ile Lys Gly Ala Ile Phe Pro 
    930                 935                 940                 


Ile Pro Val Arg Pro His Cys Lys Met Pro Val Asp Thr Ala His Pro 
945                 950                 955                 960 


Gly Ser Pro Glu Leu Ile Thr Phe His Gly Val Lys Gly Glu Lys Gly 
                965                 970                 975     


Ser Trp Gly Leu Pro Gly Ser Lys Gly Glu Lys Gly Asp Gln Gly Ala 
            980                 985                 990         


Gln Gly Pro Pro Gly Pro Pro Leu  Asp Leu Ala Tyr Leu  Arg His Phe 
        995                 1000                 1005             


Leu Asn  Asn Leu Lys Gly Glu  Asn Gly Asp Lys Gly  Phe Lys Gly 
    1010                 1015                 1020             


Glu Lys  Gly Glu Lys Gly Asp  Ile Asn Gly Ser Phe  Leu Met Ser 
    1025                 1030                 1035             


Gly Pro  Pro Gly Leu Pro Gly  Asn Pro Gly Pro Ala  Gly Gln Lys 
    1040                 1045                 1050             


Gly Glu  Thr Val Val Gly Pro  Gln Gly Pro Pro Gly  Ala Pro Gly 
    1055                 1060                 1065             


Leu Pro  Gly Pro Pro Gly Phe  Gly Arg Pro Gly Asp  Pro Gly Pro 
    1070                 1075                 1080             


Pro Gly  Pro Pro Gly Pro Pro  Gly Pro Pro Ala Ile  Leu Gly Ala 
    1085                 1090                 1095             


Ala Val  Ala Leu Pro Gly Pro  Pro Gly Pro Pro Gly  Gln Pro Gly 
    1100                 1105                 1110             


Leu Pro  Gly Ser Arg Asn Leu  Val Thr Ala Phe Ser  Asn Met Asp 
    1115                 1120                 1125             


Asp Met  Leu Gln Lys Ala His  Leu Val Ile Glu Gly  Thr Phe Ile 
    1130                 1135                 1140             


Tyr Leu  Arg Asp Ser Thr Glu  Phe Phe Ile Arg Val  Arg Asp Gly 
    1145                 1150                 1155             


Trp Lys  Lys Leu Gln Leu Gly  Glu Leu Ile Pro Ile  Pro Ala Asp 
    1160                 1165                 1170             


Ser Pro  Pro Pro Pro Ala Leu  Ser Ser Asn Pro His  Gln Leu Leu 
    1175                 1180                 1185             


Pro Pro  Pro Asn Pro Ile Ser  Ser Ala Asn Tyr Glu  Lys Pro Ala 
    1190                 1195                 1200             


Leu His  Leu Ala Ala Leu Asn  Met Pro Phe Ser Gly  Asp Ile Arg 
    1205                 1210                 1215             


Ala Asp  Phe Gln Cys Phe Lys  Gln Ala Arg Ala Ala  Gly Leu Leu 
    1220                 1225                 1230             


Ser Thr  Tyr Arg Ala Phe Leu  Ser Ser His Leu Gln  Asp Leu Ser 
    1235                 1240                 1245             


Thr Ile  Val Arg Lys Ala Glu  Arg Tyr Ser Leu Pro  Ile Val Asn 
    1250                 1255                 1260             


Leu Lys  Gly Gln Val Leu Phe  Asn Asn Trp Asp Ser  Ile Phe Ser 
    1265                 1270                 1275             


Gly His  Gly Gly Gln Phe Asn  Met His Ile Pro Ile  Tyr Ser Phe 
    1280                 1285                 1290             


Asp Gly  Arg Asp Ile Met Thr  Asp Pro Ser Trp Pro  Gln Lys Val 
    1295                 1300                 1305             


Ile Trp  His Gly Ser Ser Pro  His Gly Val Arg Leu  Val Asp Asn 
    1310                 1315                 1320             


Tyr Cys  Glu Ala Trp Arg Thr  Ala Asp Thr Ala Val  Thr Gly Leu 
    1325                 1330                 1335             


Ala Ser  Pro Leu Ser Thr Gly  Lys Ile Leu Asp Gln  Lys Ala Tyr 
    1340                 1345                 1350             


Ser Cys  Ala Asn Arg Leu Ile  Val Leu Cys Ile Glu  Asn Ser Phe 
    1355                 1360                 1365             


Met Thr  Asp Ala Arg Lys 
    1370                 


<210>  3241
<211>  235
<212>  PRT
<213>  Homo Sapiens

<400>  3241

Gly Glu Pro Gly Pro Pro Gly Arg Gly Val Gln Gly Pro Gln Gly Glu 
1               5                   10                  15      


Pro Gly Ala Pro Gly Leu Pro Gly Ile Gln Gly Leu Pro Gly Pro Arg 
            20                  25                  30          


Gly Pro Pro Gly Pro Thr Gly Glu Lys Gly Ala Gln Gly Ser Pro Gly 
        35                  40                  45              


Val Lys Gly Ala Thr Gly Pro Val Gly Pro Pro Gly Ala Ser Val Ser 
    50                  55                  60                  


Gly Pro Pro Gly Arg Asp Gly Gln Gln Gly Gln Thr Gly Leu Arg Gly 
65                  70                  75                  80  


Thr Pro Gly Glu Lys Gly Pro Arg Gly Glu Lys Gly Glu Pro Gly Glu 
                85                  90                  95      


Cys Ser Cys Pro Ser Gln Gly Asp Leu Ile Phe Ser Gly Met Pro Gly 
            100                 105                 110         


Pro Pro Gly Ile Pro Gly Pro Pro Gly Pro Pro Gly Val Pro Gly Leu 
        115                 120                 125             


Gln Gly Val Pro Gly Asn Asn Gly Leu Pro Gly Gln Pro Gly Leu Thr 
    130                 135                 140                 


Ala Glu Leu Gly Ser Leu Pro Ile Glu Gln His Leu Leu Lys Ser Ile 
145                 150                 155                 160 


Cys Gly Asp Cys Val Gln Gly Gln Arg Ala His Pro Gly Tyr Leu Val 
                165                 170                 175     


Glu Lys Gly Glu Lys Gly Asp Gln Gly Ile Pro Gly Val Pro Gly Leu 
            180                 185                 190         


Asp Asn Cys Ala Gln Cys Phe Leu Ser Leu Glu Arg Pro Arg Ala Glu 
        195                 200                 205             


Glu Ala Arg Gly Asp Asn Ser Glu Gly Asp Pro Gly Cys Val Gly Ser 
    210                 215                 220                 


Pro Gly Leu Pro Gly Pro Pro Gly Leu Pro Gly 
225                 230                 235 


<210>  3242
<211>  224
<212>  PRT
<213>  Homo Sapiens

<400>  3242

Gly Pro Pro Gly Ser Glu Gly Leu Pro Gly Pro Pro Gly Pro Ala Gly 
1               5                   10                  15      


Pro Arg Gly Glu Arg Gly Pro Gln Gly Asn Ser Gly Glu Lys Gly Asp 
            20                  25                  30          


Gln Gly Phe Gln Gly Gln Pro Gly Phe Pro Gly Pro Pro Gly Pro Pro 
        35                  40                  45              


Gly Phe Pro Gly Lys Val Gly Ser Pro Gly Pro Pro Gly Pro Gln Ala 
    50                  55                  60                  


Glu Lys Gly Pro Ala Gly Leu Asp Gly Leu Asp Gly Lys Asp Gly Lys 
65                  70                  75                  80  


Pro Gly Leu Arg Gly Asp Pro Gly Pro Ala Gly Pro Pro Gly Leu Met 
                85                  90                  95      


Gly Pro Pro Gly Phe Lys Gly Lys Thr Gly His Pro Gly Leu Pro Gly 
            100                 105                 110         


Pro Lys Gly Asp Cys Gly Lys Pro Gly Pro Pro Gly Ser Thr Gly Arg 
        115                 120                 125             


Pro Gly Ala Glu Gly Glu Pro Gly Ala Met Gly Pro Gln Gly Arg Pro 
    130                 135                 140                 


Gly Pro Pro Gly His Val Gly Pro Pro Gly Pro Pro Gly Gln Pro Gly 
145                 150                 155                 160 


Pro Ala Gly Ile Ser Ala Val Gly Leu Lys Gly Asp Arg Gly Ala Thr 
                165                 170                 175     


Gly Glu Arg Gly Leu Ala Gly Leu Pro Gly Gln Pro Gly Pro Pro Gly 
            180                 185                 190         


His Pro Gly Pro Pro Gly Glu Pro Gly Thr Asp Gly Ala Ala Gly Lys 
        195                 200                 205             


Glu Gly Pro Pro Gly Lys Gln Gly Phe Tyr Gly Pro Pro Gly Pro Lys 
    210                 215                 220                 


<210>  3243
<211>  308
<212>  PRT
<213>  Homo Sapiens

<400>  3243

Lys Val Tyr Thr Arg Cys Phe Cys Leu Glu Glu Pro Gln Asn Ser Glu 
1               5                   10                  15      


Val Asp Ala Gln Leu Thr Gly Arg Ile Ser Gln Lys Ala Glu Arg Gly 
            20                  25                  30          


Ala Lys Val His Gln Glu Thr Ala Ala Asp Glu Cys Pro Pro Cys Val 
        35                  40                  45              


His Gly Ala Arg Asp Ser Asn Gly Gly Lys Gly Glu Arg Gly Leu Pro 
    50                  55                  60                  


Gly Pro Pro Gly Ser Lys Gly Glu Lys Gly Ala Arg Gly Asn Asp Cys 
65                  70                  75                  80  


Val Arg Ile Ser Pro Asp Ala Pro Leu Gln Cys Ala Glu Gly Pro Lys 
                85                  90                  95      


Gly Glu Lys Gly Glu Ser Gly Ala Leu Gly Pro Ser Gly Leu Pro Gly 
            100                 105                 110         


Ser Thr Gly Glu Lys Gly Gln Lys Gly Glu Lys Gly Asp Gly Gly Ile 
        115                 120                 125             


Lys Gly Val Pro Gly Lys Pro Gly Arg Asp Gly Arg Pro Gly Glu Ile 
    130                 135                 140                 


Cys Val Ile Gly Pro Lys Gly Gln Lys Gly Asp Pro Gly Phe Val Gly 
145                 150                 155                 160 


Pro Glu Gly Leu Ala Gly Glu Pro Gly Pro Pro Gly Leu Pro Gly Pro 
                165                 170                 175     


Pro Gly Ile Gly Leu Pro Gly Thr Pro Gly Asp Pro Gly Gly Pro Pro 
            180                 185                 190         


Gly Pro Lys Gly Asp Lys Gly Ser Ser Gly Ile Pro Gly Lys Glu Gly 
        195                 200                 205             


Pro Gly Gly Lys Pro Gly Lys Pro Gly Val Lys Gly Glu Lys Gly Asp 
    210                 215                 220                 


Pro Cys Glu Val Cys Pro Thr Leu Pro Glu Gly Phe Gln Asn Phe Val 
225                 230                 235                 240 


Gly Leu Pro Gly Lys Pro Gly Pro Lys Gly Glu Pro Gly Asp Pro Val 
                245                 250                 255     


Pro Ala Arg Gly Asp Pro Gly Ile Gln Gly Ile Lys Gly Glu Lys Gly 
            260                 265                 270         


Glu Pro Cys Leu Ser Cys Ser Ser Val Val Gly Ala Gln His Leu Val 
        275                 280                 285             


Ser Ser Thr Gly Ala Ser Gly Asp Val Gly Ser Pro Gly Phe Gly Leu 
    290                 295                 300                 


Pro Gly Leu Pro 
305             


<210>  3244
<211>  1604
<212>  PRT
<213>  Homo Sapiens

<400>  3244

Met Trp Val Ser Trp Ala Pro Gly Leu Trp Leu Leu Gly Leu Trp Ala 
1               5                   10                  15      


Thr Phe Gly His Gly Ala Asn Thr Gly Ala Gln Cys Pro Pro Ser Gln 
            20                  25                  30          


Gln Glu Gly Leu Lys Leu Glu His Ser Ser Ser Leu Pro Ala Asn Val 
        35                  40                  45              


Thr Gly Phe Asn Leu Ile His Arg Leu Ser Leu Met Lys Thr Ser Ala 
    50                  55                  60                  


Ile Lys Lys Ile Arg Asn Pro Lys Gly Pro Leu Ile Leu Arg Leu Gly 
65                  70                  75                  80  


Ala Ala Pro Val Thr Gln Pro Thr Arg Arg Val Phe Pro Arg Gly Leu 
                85                  90                  95      


Pro Glu Glu Phe Ala Leu Val Leu Thr Leu Leu Leu Lys Lys His Thr 
            100                 105                 110         


His Gln Lys Thr Trp Tyr Leu Phe Gln Val Thr Asp Ala Asn Gly Tyr 
        115                 120                 125             


Pro Gln Ile Ser Leu Glu Val Asn Ser Gln Glu Arg Ser Leu Glu Leu 
    130                 135                 140                 


Arg Ala Gln Gly Gln Asp Gly Asp Phe Val Ser Cys Ile Phe Pro Val 
145                 150                 155                 160 


Pro Gln Leu Phe Asp Leu Arg Trp His Lys Leu Met Leu Ser Val Ala 
                165                 170                 175     


Gly Arg Val Ala Ser Val His Val Asp Cys Ser Ser Ala Ser Ser Gln 
            180                 185                 190         


Pro Leu Gly Pro Arg Arg Pro Met Arg Pro Val Gly His Val Phe Leu 
        195                 200                 205             


Gly Leu Asp Ala Glu Gln Gly Lys Pro Val Ser Phe Asp Leu Gln Gln 
    210                 215                 220                 


Val His Ile Tyr Cys Asp Pro Glu Leu Val Leu Glu Glu Gly Cys Cys 
225                 230                 235                 240 


Glu Ile Leu Pro Ala Gly Cys Pro Pro Glu Thr Ser Lys Ala Arg Arg 
                245                 250                 255     


Asp Thr Gln Ser Asn Glu Leu Ile Glu Ile Asn Pro Gln Ser Glu Gly 
            260                 265                 270         


Lys Val Tyr Thr Arg Cys Phe Cys Leu Glu Glu Pro Gln Asn Ser Glu 
        275                 280                 285             


Val Asp Ala Gln Leu Thr Gly Arg Ile Ser Gln Lys Ala Glu Arg Gly 
    290                 295                 300                 


Ala Lys Val His Gln Glu Thr Ala Ala Asp Glu Cys Pro Pro Cys Val 
305                 310                 315                 320 


His Gly Ala Arg Asp Ser Asn Val Thr Leu Ala Pro Ser Gly Pro Lys 
                325                 330                 335     


Gly Gly Lys Gly Glu Arg Gly Leu Pro Gly Pro Pro Gly Ser Lys Gly 
            340                 345                 350         


Glu Lys Gly Ala Arg Gly Asn Asp Cys Val Arg Ile Ser Pro Asp Ala 
        355                 360                 365             


Pro Leu Gln Cys Ala Glu Gly Pro Lys Gly Glu Lys Gly Glu Ser Gly 
    370                 375                 380                 


Ala Leu Gly Pro Ser Gly Leu Pro Gly Ser Thr Gly Glu Lys Gly Gln 
385                 390                 395                 400 


Lys Gly Glu Lys Gly Asp Gly Gly Ile Lys Gly Val Pro Gly Lys Pro 
                405                 410                 415     


Gly Arg Asp Gly Arg Pro Gly Glu Ile Cys Val Ile Gly Pro Lys Gly 
            420                 425                 430         


Gln Lys Gly Asp Pro Gly Phe Val Gly Pro Glu Gly Leu Ala Gly Glu 
        435                 440                 445             


Pro Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Ile Gly Leu Pro Gly 
    450                 455                 460                 


Thr Pro Gly Asp Pro Gly Gly Pro Pro Gly Pro Lys Gly Asp Lys Gly 
465                 470                 475                 480 


Ser Ser Gly Ile Pro Gly Lys Glu Gly Pro Gly Gly Lys Pro Gly Lys 
                485                 490                 495     


Pro Gly Val Lys Gly Glu Lys Gly Asp Pro Cys Glu Val Cys Pro Thr 
            500                 505                 510         


Leu Pro Glu Gly Phe Gln Asn Phe Val Gly Leu Pro Gly Lys Pro Gly 
        515                 520                 525             


Pro Lys Gly Glu Pro Gly Asp Pro Val Pro Ala Arg Gly Asp Pro Gly 
    530                 535                 540                 


Ile Gln Gly Ile Lys Gly Glu Lys Gly Glu Pro Cys Leu Ser Cys Ser 
545                 550                 555                 560 


Ser Val Val Gly Ala Gln His Leu Val Ser Ser Thr Gly Ala Ser Gly 
                565                 570                 575     


Asp Val Gly Ser Pro Gly Phe Gly Leu Pro Gly Leu Pro Gly Arg Ala 
            580                 585                 590         


Gly Val Pro Gly Leu Lys Gly Glu Lys Gly Asn Phe Gly Glu Ala Gly 
        595                 600                 605             


Pro Ala Gly Ser Pro Gly Pro Pro Gly Pro Val Gly Pro Ala Gly Ile 
    610                 615                 620                 


Lys Gly Ala Lys Gly Glu Pro Cys Glu Pro Cys Pro Ala Leu Ser Asn 
625                 630                 635                 640 


Leu Gln Asp Gly Asp Val Arg Val Val Ala Leu Pro Gly Pro Ser Gly 
                645                 650                 655     


Glu Lys Gly Glu Pro Gly Pro Pro Gly Phe Gly Leu Pro Gly Lys Gln 
            660                 665                 670         


Gly Lys Ala Gly Glu Arg Gly Leu Lys Gly Gln Lys Gly Asp Ala Gly 
        675                 680                 685             


Asn Pro Gly Asp Pro Gly Thr Pro Gly Thr Thr Gly Arg Pro Gly Leu 
    690                 695                 700                 


Ser Gly Glu Pro Gly Val Gln Gly Pro Ala Gly Pro Lys Gly Glu Lys 
705                 710                 715                 720 


Gly Asp Gly Cys Thr Ala Cys Pro Ser Leu Gln Gly Thr Val Thr Asp 
                725                 730                 735     


Met Ala Gly Arg Pro Gly Gln Pro Gly Pro Lys Gly Glu Gln Gly Pro 
            740                 745                 750         


Glu Gly Val Gly Arg Pro Gly Lys Pro Gly Gln Pro Gly Leu Pro Gly 
        755                 760                 765             


Val Gln Gly Pro Pro Gly Leu Lys Gly Val Gln Gly Glu Pro Gly Pro 
    770                 775                 780                 


Pro Gly Arg Gly Val Gln Gly Pro Gln Gly Glu Pro Gly Ala Pro Gly 
785                 790                 795                 800 


Leu Pro Gly Ile Gln Gly Leu Pro Gly Pro Arg Gly Pro Pro Gly Pro 
                805                 810                 815     


Thr Gly Glu Lys Gly Ala Gln Gly Ser Pro Gly Val Lys Gly Ala Thr 
            820                 825                 830         


Gly Pro Val Gly Pro Pro Gly Ala Ser Val Ser Gly Pro Pro Gly Arg 
        835                 840                 845             


Asp Gly Gln Gln Gly Gln Thr Gly Leu Arg Gly Thr Pro Gly Glu Lys 
    850                 855                 860                 


Gly Pro Arg Gly Glu Lys Gly Glu Pro Gly Glu Cys Ser Cys Pro Ser 
865                 870                 875                 880 


Gln Gly Asp Leu Ile Phe Ser Gly Met Pro Gly Ala Pro Gly Leu Trp 
                885                 890                 895     


Met Gly Ser Ser Trp Gln Pro Gly Pro Gln Gly Pro Pro Gly Ile Pro 
            900                 905                 910         


Gly Pro Pro Gly Pro Pro Gly Val Pro Gly Leu Gln Gly Val Pro Gly 
        915                 920                 925             


Asn Asn Gly Leu Pro Gly Gln Pro Gly Leu Thr Ala Glu Leu Gly Ser 
    930                 935                 940                 


Leu Pro Ile Glu Gln His Leu Leu Lys Ser Ile Cys Gly Asp Cys Val 
945                 950                 955                 960 


Gln Gly Gln Arg Ala His Pro Gly Tyr Leu Val Glu Lys Gly Glu Lys 
                965                 970                 975     


Gly Asp Gln Gly Ile Pro Gly Val Pro Gly Leu Asp Asn Cys Ala Gln 
            980                 985                 990         


Cys Phe Leu Ser Leu Glu Arg Pro  Arg Ala Glu Glu Ala  Arg Gly Asp 
        995                 1000                 1005             


Asn Ser  Glu Gly Asp Pro Gly  Cys Val Gly Ser Pro  Gly Leu Pro 
    1010                 1015                 1020             


Gly Pro  Pro Gly Leu Pro Gly  Gln Arg Gly Glu Glu  Gly Pro Pro 
    1025                 1030                 1035             


Gly Met  Arg Gly Ser Pro Gly  Pro Pro Gly Pro Ile  Gly Pro Pro 
    1040                 1045                 1050             


Gly Phe  Pro Gly Ala Val Gly  Ser Pro Gly Leu Pro  Gly Leu Gln 
    1055                 1060                 1065             


Gly Glu  Arg Gly Leu Thr Gly  Leu Thr Gly Asp Lys  Gly Glu Pro 
    1070                 1075                 1080             


Gly Pro  Pro Gly Gln Pro Gly  Tyr Pro Gly Ala Thr  Gly Pro Pro 
    1085                 1090                 1095             


Gly Leu  Pro Gly Ile Lys Gly  Glu Arg Gly Tyr Thr  Gly Ser Ala 
    1100                 1105                 1110             


Gly Glu  Lys Gly Glu Pro Gly  Pro Pro Gly Ser Glu  Gly Leu Pro 
    1115                 1120                 1125             


Gly Pro  Pro Gly Pro Ala Gly  Pro Arg Gly Glu Arg  Gly Pro Gln 
    1130                 1135                 1140             


Gly Asn  Ser Gly Glu Lys Gly  Asp Gln Gly Phe Gln  Gly Gln Pro 
    1145                 1150                 1155             


Gly Phe  Pro Gly Pro Pro Gly  Pro Pro Gly Phe Pro  Gly Lys Val 
    1160                 1165                 1170             


Gly Ser  Pro Gly Pro Pro Gly  Pro Gln Ala Glu Lys  Gly Ser Glu 
    1175                 1180                 1185             


Gly Ile  Arg Gly Pro Ser Gly  Leu Pro Gly Ser Pro  Gly Pro Pro 
    1190                 1195                 1200             


Gly Pro  Pro Gly Ile Gln Gly  Pro Ala Gly Leu Asp  Gly Leu Asp 
    1205                 1210                 1215             


Gly Lys  Asp Gly Lys Pro Gly  Leu Arg Gly Asp Pro  Gly Pro Ala 
    1220                 1225                 1230             


Gly Pro  Pro Gly Leu Met Gly  Pro Pro Gly Phe Lys  Gly Lys Thr 
    1235                 1240                 1245             


Gly His  Pro Gly Leu Pro Gly  Pro Lys Gly Asp Cys  Gly Lys Pro 
    1250                 1255                 1260             


Gly Pro  Pro Gly Ser Thr Gly  Arg Pro Gly Ala Glu  Gly Glu Pro 
    1265                 1270                 1275             


Gly Ala  Met Gly Pro Gln Gly  Arg Pro Gly Pro Pro  Gly His Val 
    1280                 1285                 1290             


Gly Pro  Pro Gly Pro Pro Gly  Gln Pro Gly Pro Ala  Gly Ile Ser 
    1295                 1300                 1305             


Ala Val  Gly Leu Lys Gly Asp  Arg Gly Ala Thr Gly  Glu Arg Gly 
    1310                 1315                 1320             


Leu Ala  Gly Leu Pro Gly Gln  Pro Gly Pro Pro Gly  His Pro Gly 
    1325                 1330                 1335             


Pro Pro  Gly Glu Pro Gly Thr  Asp Gly Ala Ala Gly  Lys Glu Gly 
    1340                 1345                 1350             


Pro Pro  Gly Lys Gln Gly Phe  Tyr Gly Pro Pro Gly  Pro Lys Gly 
    1355                 1360                 1365             


Asp Pro  Gly Ala Ala Gly Gln  Lys Gly Gln Ala Gly  Glu Lys Gly 
    1370                 1375                 1380             


Arg Ala  Gly Met Pro Gly Gly  Pro Gly Lys Ser Gly  Ser Met Gly 
    1385                 1390                 1395             


Pro Val  Gly Pro Pro Gly Pro  Ala Gly Glu Arg Gly  His Pro Gly 
    1400                 1405                 1410             


Ala Pro  Gly Pro Ser Gly Ser  Pro Gly Leu Pro Gly  Val Pro Gly 
    1415                 1420                 1425             


Ser Met  Gly Asp Met Val Asn  Tyr Asp Glu Ile Lys  Arg Phe Ile 
    1430                 1435                 1440             


Arg Gln  Glu Ile Ile Lys Met  Phe Asp Glu Arg Met  Ala Tyr Tyr 
    1445                 1450                 1455             


Thr Ser  Arg Met Gln Phe Pro  Met Glu Met Ala Ala  Ala Pro Gly 
    1460                 1465                 1470             


Arg Pro  Gly Pro Pro Gly Lys  Asp Gly Ala Pro Gly  Arg Pro Gly 
    1475                 1480                 1485             


Ala Pro  Gly Ser Pro Gly Leu  Pro Gly Gln Ile Gly  Arg Glu Gly 
    1490                 1495                 1500             


Arg Gln  Gly Leu Pro Gly Val  Arg Gly Leu Pro Gly  Thr Lys Gly 
    1505                 1510                 1515             


Glu Lys  Gly Asp Ile Gly Ile  Gly Ile Ala Gly Glu  Asn Gly Leu 
    1520                 1525                 1530             


Pro Gly  Pro Pro Gly Pro Gln  Gly Pro Pro Gly Tyr  Gly Lys Met 
    1535                 1540                 1545             


Gly Ala  Thr Gly Pro Met Gly  Gln Gln Gly Ile Pro  Gly Ile Pro 
    1550                 1555                 1560             


Gly Pro  Pro Gly Pro Met Gly  Gln Pro Gly Lys Ala  Gly His Cys 
    1565                 1570                 1575             


Asn Pro  Ser Asp Cys Phe Gly  Ala Met Pro Met Glu  Gln Gln Tyr 
    1580                 1585                 1590             


Pro Pro  Met Lys Thr Met Lys  Gly Pro Phe Gly 
    1595                 1600                 


<210>  3245
<211>  966
<212>  PRT
<213>  Homo Sapiens

<400>  3245

Met Trp Val Ser Trp Ala Pro Gly Leu Trp Leu Leu Gly Leu Trp Ala 
1               5                   10                  15      


Thr Phe Gly His Gly Ala Asn Thr Gly Ala Gln Cys Pro Pro Ser Gln 
            20                  25                  30          


Gln Glu Gly Leu Lys Leu Glu His Ser Ser Ser Leu Pro Ala Asn Val 
        35                  40                  45              


Thr Gly Phe Asn Leu Ile His Arg Leu Ser Leu Met Lys Thr Ser Ala 
    50                  55                  60                  


Ile Lys Lys Ile Arg Asn Pro Lys Gly Pro Leu Ile Leu Arg Leu Gly 
65                  70                  75                  80  


Ala Ala Pro Val Thr Gln Pro Thr Arg Arg Val Phe Pro Arg Gly Leu 
                85                  90                  95      


Pro Glu Glu Phe Ala Leu Val Leu Thr Leu Leu Leu Lys Lys His Thr 
            100                 105                 110         


His Gln Lys Thr Trp Tyr Leu Phe Gln Val Thr Asp Ala Asn Gly Tyr 
        115                 120                 125             


Pro Gln Ile Ser Leu Glu Val Asn Ser Gln Glu Arg Ser Leu Glu Leu 
    130                 135                 140                 


Arg Ala Gln Gly Gln Asp Gly Asp Phe Val Ser Cys Ile Phe Pro Val 
145                 150                 155                 160 


Pro Gln Leu Phe Asp Leu Arg Trp His Lys Leu Met Leu Ser Val Ala 
                165                 170                 175     


Gly Arg Val Ala Ser Val His Val Asp Cys Ser Ser Ala Ser Ser Gln 
            180                 185                 190         


Pro Leu Gly Pro Arg Arg Pro Met Arg Pro Val Gly His Val Phe Leu 
        195                 200                 205             


Gly Leu Asp Ala Glu Gln Gly Lys Pro Val Ser Phe Asp Leu Gln Gln 
    210                 215                 220                 


Val His Ile Tyr Cys Asp Pro Glu Leu Val Leu Glu Glu Gly Cys Cys 
225                 230                 235                 240 


Glu Ile Leu Pro Ala Gly Cys Pro Pro Glu Thr Ser Lys Ala Arg Arg 
                245                 250                 255     


Asp Thr Gln Ser Asn Glu Leu Ile Glu Ile Asn Pro Gln Ser Glu Gly 
            260                 265                 270         


Lys Val Tyr Thr Arg Cys Phe Cys Leu Glu Glu Pro Gln Asn Ser Glu 
        275                 280                 285             


Val Asp Ala Gln Leu Thr Gly Arg Ile Ser Gln Lys Ala Glu Arg Gly 
    290                 295                 300                 


Ala Lys Val His Gln Glu Thr Ala Ala Asp Glu Cys Pro Pro Cys Val 
305                 310                 315                 320 


His Gly Ala Arg Asp Ser Asn Val Thr Leu Ala Pro Ser Gly Pro Lys 
                325                 330                 335     


Gly Gly Lys Gly Glu Arg Gly Leu Pro Gly Pro Pro Gly Ser Lys Gly 
            340                 345                 350         


Glu Lys Gly Ala Arg Gly Asn Asp Cys Val Arg Ile Ser Pro Asp Ala 
        355                 360                 365             


Pro Leu Gln Cys Ala Glu Gly Pro Lys Gly Glu Lys Gly Glu Ser Gly 
    370                 375                 380                 


Ala Leu Gly Pro Ser Gly Leu Pro Gly Ser Thr Gly Glu Lys Gly Gln 
385                 390                 395                 400 


Lys Gly Glu Lys Gly Asp Gly Gly Ile Lys Gly Val Pro Gly Lys Pro 
                405                 410                 415     


Gly Arg Asp Gly Arg Pro Gly Glu Ile Cys Val Ile Gly Pro Lys Gly 
            420                 425                 430         


Gln Lys Gly Asp Pro Gly Phe Val Gly Pro Glu Gly Leu Ala Gly Glu 
        435                 440                 445             


Pro Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Ile Gly Leu Pro Gly 
    450                 455                 460                 


Thr Pro Gly Asp Pro Gly Gly Pro Pro Gly Pro Lys Gly Asp Lys Gly 
465                 470                 475                 480 


Ser Ser Gly Ile Pro Gly Lys Glu Gly Pro Gly Gly Lys Pro Gly Lys 
                485                 490                 495     


Pro Gly Val Lys Gly Glu Lys Gly Asp Pro Cys Glu Val Cys Pro Thr 
            500                 505                 510         


Leu Pro Glu Gly Phe Gln Asn Phe Val Gly Leu Pro Gly Lys Pro Gly 
        515                 520                 525             


Pro Lys Gly Glu Pro Gly Asp Pro Val Pro Ala Arg Gly Asp Pro Gly 
    530                 535                 540                 


Ile Gln Gly Ile Lys Gly Glu Lys Gly Glu Pro Cys Leu Ser Cys Ser 
545                 550                 555                 560 


Ser Val Val Gly Ala Gln His Leu Val Ser Ser Thr Gly Ala Ser Gly 
                565                 570                 575     


Asp Val Gly Ser Pro Gly Phe Gly Leu Pro Gly Leu Pro Gly Arg Ala 
            580                 585                 590         


Gly Val Pro Gly Leu Lys Gly Glu Lys Gly Asn Phe Gly Glu Ala Gly 
        595                 600                 605             


Pro Ala Gly Ser Pro Gly Pro Pro Gly Pro Val Gly Pro Ala Gly Ile 
    610                 615                 620                 


Lys Gly Ala Lys Gly Glu Pro Cys Glu Pro Cys Pro Ala Leu Ser Asn 
625                 630                 635                 640 


Leu Gln Asp Gly Asp Val Arg Val Val Ala Leu Pro Gly Pro Ser Gly 
                645                 650                 655     


Glu Lys Gly Glu Pro Gly Pro Pro Gly Phe Gly Leu Pro Gly Lys Gln 
            660                 665                 670         


Gly Lys Ala Gly Glu Arg Gly Leu Lys Gly Gln Lys Gly Asp Ala Gly 
        675                 680                 685             


Asn Pro Gly Asp Pro Gly Thr Pro Gly Thr Thr Gly Arg Pro Gly Leu 
    690                 695                 700                 


Ser Gly Glu Pro Gly Val Gln Gly Pro Ala Gly Pro Lys Gly Glu Lys 
705                 710                 715                 720 


Gly Asp Gly Cys Thr Ala Cys Pro Ser Leu Gln Gly Thr Val Thr Asp 
                725                 730                 735     


Met Ala Gly Arg Pro Gly Gln Pro Gly Pro Lys Gly Glu Gln Gly Pro 
            740                 745                 750         


Glu Gly Val Gly Arg Pro Gly Lys Pro Gly Gln Pro Gly Leu Pro Gly 
        755                 760                 765             


Val Gln Gly Pro Pro Gly Leu Lys Gly Val Gln Gly Glu Pro Gly Pro 
    770                 775                 780                 


Pro Gly Arg Gly Val Gln Gly Pro Gln Gly Glu Pro Gly Ala Pro Gly 
785                 790                 795                 800 


Leu Pro Gly Ile Gln Gly Leu Pro Gly Pro Arg Gly Pro Pro Gly Pro 
                805                 810                 815     


Thr Gly Glu Lys Gly Ala Gln Gly Ser Pro Gly Val Lys Gly Ala Thr 
            820                 825                 830         


Gly Pro Val Gly Pro Pro Gly Ala Ser Val Ser Gly Pro Pro Gly Arg 
        835                 840                 845             


Asp Gly Gln Gln Gly Gln Thr Gly Leu Arg Gly Thr Pro Gly Glu Lys 
    850                 855                 860                 


Gly Pro Arg Gly Glu Lys Gly Glu Pro Gly Glu Cys Ser Cys Pro Ser 
865                 870                 875                 880 


Gln Gly Asp Leu Ile Phe Ser Gly Met Pro Gly Pro Pro Gly Ile Pro 
                885                 890                 895     


Gly Pro Pro Gly Pro Pro Gly Val Pro Gly Leu Gln Val Lys Gly Glu 
            900                 905                 910         


Lys Arg Met Arg Ser Leu Gly Gly Arg Ala His Gly Ser Gly Trp Leu 
        915                 920                 925             


Leu Pro Ala Gly Pro Gln Gly Cys Cys Ser Pro Thr Pro Lys Thr Gln 
    930                 935                 940                 


Thr Cys His Phe Ser Leu Leu Cys Leu Pro Ala Ser Gln Gly Gly Lys 
945                 950                 955                 960 


Glu Gly Pro Leu Ser Leu 
                965     


<210>  3246
<211>  687
<212>  PRT
<213>  Homo Sapiens

<400>  3246

Gly Glu Val Gly Ala Asp Gly Val Pro Gly Phe Pro Gly Leu Pro Gly 
1               5                   10                  15      


Arg Glu Gly Ile Ala Gly Pro Gln Gly Pro Lys Gly Asp Arg Gly Ser 
            20                  25                  30          


Arg Gly Glu Lys Gly Asp Pro Gly Lys Asp Gly Val Gly Gln Pro Gly 
        35                  40                  45              


Leu Pro Gly Pro Pro Gly Pro Pro Gly Pro Val Val Tyr Val Ser Glu 
    50                  55                  60                  


Gln Asp Gly Ser Val Leu Ser Val Pro Gly Pro Glu Gly Arg Pro Gly 
65                  70                  75                  80  


Phe Ala Gly Phe Pro Gly Pro Ala Gly Pro Lys Gly Asn Leu Gly Ser 
                85                  90                  95      


Lys Gly Glu Arg Gly Ser Pro Gly Pro Lys Gly Glu Lys Gly Glu Pro 
            100                 105                 110         


Gly Ser Ile Phe Ser Pro Asp Gly Gly Ala Leu Gly Pro Ala Gln Lys 
        115                 120                 125             


Gly Ala Lys Gly Glu Pro Gly Phe Arg Gly Pro Pro Gly Pro Tyr Gly 
    130                 135                 140                 


Arg Pro Gly Tyr Lys Gly Glu Ile Gly Phe Pro Gly Arg Pro Gly Arg 
145                 150                 155                 160 


Pro Gly Met Asn Gly Leu Lys Gly Glu Lys Gly Glu Pro Gly Asp Ala 
                165                 170                 175     


Ser Leu Gly Phe Gly Met Arg Gly Met Pro Gly Pro Pro Gly Pro Pro 
            180                 185                 190         


Gly Pro Pro Gly Pro Pro Gly Thr Pro Val Tyr Asp Ser Asn Val Phe 
        195                 200                 205             


Ala Glu Ser Ser Arg Pro Gly Pro Pro Gly Leu Pro Gly Asn Gln Gly 
    210                 215                 220                 


Pro Pro Gly Pro Lys Gly Ala Lys Gly Glu Val Gly Pro Pro Gly Pro 
225                 230                 235                 240 


Pro Gly Gln Phe Pro Phe Asp Phe Leu Gln Leu Glu Ala Glu Met Lys 
                245                 250                 255     


Gly Glu Lys Gly Asp Arg Gly Asp Ala Gly Gln Lys Gly Glu Arg Gly 
            260                 265                 270         


Glu Pro Gly Gly Gly Gly Phe Phe Gly Ser Ser Leu Pro Gly Pro Pro 
        275                 280                 285             


Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly Tyr Pro Gly Ile Pro Gly 
    290                 295                 300                 


Pro Lys Gly Glu Ser Ile Arg Gly Gln Pro Gly Pro Pro Gly Pro Gln 
305                 310                 315                 320 


Gly Pro Pro Gly Ile Gly Tyr Glu Gly Arg Gln Gly Pro Pro Gly Pro 
                325                 330                 335     


Pro Gly Pro Pro Gly Pro Pro Ser Phe Pro Gly Pro His Arg Gln Thr 
            340                 345                 350         


Ile Ser Val Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro 
        355                 360                 365             


Gly Thr Met Gly Ala Ser Ser Gly Gln Val Arg Leu Trp Ala Thr Arg 
    370                 375                 380                 


Gln Ala Met Leu Gly Gln Val His Glu Val Pro Glu Gly Trp Leu Ile 
385                 390                 395                 400 


Phe Val Ala Glu Gln Glu Glu Leu Tyr Val Arg Val Gln Asn Gly Phe 
                405                 410                 415     


Arg Lys Val Gln Leu Glu Ala Arg Thr Pro Leu Pro Arg Gly Thr Asp 
            420                 425                 430         


Asn Glu Val Ala Ala Leu Gln Pro Pro Val Val Gln Leu His Asp Ser 
        435                 440                 445             


Asn Pro Tyr Pro Arg Arg Glu His Pro His Pro Thr Ala Arg Pro Trp 
    450                 455                 460                 


Arg Ala Asp Asp Ile Leu Ala Ser Pro Pro Arg Leu Pro Glu Pro Gln 
465                 470                 475                 480 


Pro Tyr Pro Gly Ala Pro His His Ser Ser Tyr Val His Leu Arg Pro 
                485                 490                 495     


Ala Arg Pro Thr Ser Pro Pro Ala His Ser His Arg Asp Phe Gln Pro 
            500                 505                 510         


Val Leu His Leu Val Ala Leu Asn Ser Pro Leu Ser Gly Gly Met Arg 
        515                 520                 525             


Gly Ile Arg Gly Ala Asp Phe Gln Cys Phe Gln Gln Ala Arg Ala Val 
    530                 535                 540                 


Gly Leu Ala Gly Thr Phe Arg Ala Phe Leu Ser Ser Arg Leu Gln Asp 
545                 550                 555                 560 


Leu Tyr Ser Ile Val Arg Arg Ala Asp Arg Ala Ala Val Pro Ile Val 
                565                 570                 575     


Asn Leu Lys Asp Glu Leu Leu Phe Pro Ser Trp Glu Ala Leu Phe Ser 
            580                 585                 590         


Gly Ser Glu Gly Pro Leu Lys Pro Gly Ala Arg Ile Phe Ser Phe Asp 
        595                 600                 605             


Gly Lys Asp Val Leu Arg His Pro Thr Trp Pro Gln Lys Ser Val Trp 
    610                 615                 620                 


His Gly Ser Asp Pro Asn Gly Arg Arg Leu Thr Glu Ser Tyr Cys Glu 
625                 630                 635                 640 


Thr Trp Arg Thr Glu Ala Pro Ser Ala Thr Gly Gln Ala Ser Ser Leu 
                645                 650                 655     


Leu Gly Gly Arg Leu Leu Gly Gln Ser Ala Ala Ser Cys His His Ala 
            660                 665                 670         


Tyr Ile Val Leu Cys Ile Glu Asn Ser Phe Met Thr Ala Ser Lys 
        675                 680                 685         


<210>  3247
<211>  1339
<212>  PRT
<213>  Homo Sapiens

<400>  3247

Met Ala Pro Arg Cys Pro Trp Pro Trp Pro Arg Arg Arg Arg Leu Leu 
1               5                   10                  15      


Asp Val Leu Ala Pro Leu Val Leu Leu Leu Gly Val Arg Ala Ala Ser 
            20                  25                  30          


Ala Glu Pro Glu Arg Ile Ser Glu Glu Val Gly Leu Leu Gln Leu Leu 
        35                  40                  45              


Gly Asp Pro Pro Pro Gln Gln Val Thr Gln Thr Asp Asp Pro Asp Val 
    50                  55                  60                  


Gly Leu Ala Tyr Val Phe Gly Pro Asp Ala Asn Ser Gly Gln Val Ala 
65                  70                  75                  80  


Arg Tyr His Phe Pro Ser Leu Phe Phe Arg Asp Phe Ser Leu Leu Phe 
                85                  90                  95      


His Ile Arg Pro Ala Thr Glu Gly Pro Gly Val Leu Phe Ala Ile Thr 
            100                 105                 110         


Asp Ser Ala Gln Ala Met Val Leu Leu Gly Val Lys Leu Ser Gly Val 
        115                 120                 125             


Gln Asp Gly His Gln Asp Ile Ser Leu Leu Tyr Thr Glu Pro Gly Ala 
    130                 135                 140                 


Gly Gln Thr His Thr Ala Ala Ser Phe Arg Leu Pro Ala Phe Val Gly 
145                 150                 155                 160 


Gln Trp Thr His Leu Ala Leu Ser Val Ala Gly Gly Phe Val Ala Leu 
                165                 170                 175     


Tyr Val Asp Cys Glu Glu Phe Gln Arg Met Pro Leu Ala Arg Ser Ser 
            180                 185                 190         


Arg Gly Leu Glu Leu Glu Pro Gly Ala Gly Leu Phe Val Ala Gln Ala 
        195                 200                 205             


Gly Gly Ala Asp Pro Asp Lys Phe Gln Gly Val Ile Ala Glu Leu Lys 
    210                 215                 220                 


Val Arg Arg Asp Pro Gln Val Ser Pro Met His Cys Leu Asp Glu Glu 
225                 230                 235                 240 


Gly Asp Asp Ser Asp Gly Ala Ser Gly Asp Ser Gly Ser Gly Leu Gly 
                245                 250                 255     


Asp Ala Arg Glu Leu Leu Arg Glu Glu Thr Gly Ala Ala Leu Lys Pro 
            260                 265                 270         


Arg Leu Pro Ala Pro Pro Pro Val Thr Thr Pro Pro Leu Ala Gly Gly 
        275                 280                 285             


Ser Ser Thr Glu Asp Ser Arg Ser Glu Glu Val Glu Glu Gln Thr Thr 
    290                 295                 300                 


Val Ala Ser Leu Gly Ala Gln Thr Leu Pro Gly Ser Asp Ser Val Ser 
305                 310                 315                 320 


Thr Trp Asp Gly Ser Val Arg Thr Pro Gly Gly Arg Val Lys Glu Gly 
                325                 330                 335     


Gly Leu Lys Gly Gln Lys Gly Glu Pro Gly Val Pro Gly Pro Pro Gly 
            340                 345                 350         


Arg Ala Gly Pro Pro Gly Ser Pro Cys Leu Pro Gly Pro Pro Gly Leu 
        355                 360                 365             


Pro Cys Pro Val Ser Pro Leu Gly Pro Ala Gly Pro Ala Leu Gln Thr 
    370                 375                 380                 


Val Pro Gly Pro Gln Gly Pro Pro Gly Pro Pro Gly Arg Asp Gly Thr 
385                 390                 395                 400 


Pro Gly Arg Asp Gly Glu Pro Gly Asp Pro Gly Glu Asp Gly Lys Pro 
                405                 410                 415     


Gly Asp Thr Gly Pro Gln Gly Phe Pro Gly Thr Pro Gly Asp Val Gly 
            420                 425                 430         


Pro Lys Gly Asp Lys Gly Asp Pro Gly Val Gly Glu Arg Gly Pro Pro 
        435                 440                 445             


Gly Pro Gln Gly Pro Pro Gly Pro Pro Gly Pro Ser Phe Arg His Asp 
    450                 455                 460                 


Lys Leu Thr Phe Ile Asp Met Glu Gly Ser Gly Phe Gly Gly Asp Leu 
465                 470                 475                 480 


Glu Ala Leu Arg Gly Pro Arg Gly Phe Pro Gly Pro Pro Gly Pro Pro 
                485                 490                 495     


Gly Val Pro Gly Leu Pro Gly Glu Pro Gly Arg Phe Gly Val Asn Ser 
            500                 505                 510         


Ser Asp Val Pro Gly Pro Ala Gly Leu Pro Gly Val Pro Gly Arg Glu 
        515                 520                 525             


Gly Pro Pro Gly Phe Pro Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly 
    530                 535                 540                 


Arg Glu Gly Pro Pro Gly Arg Thr Gly Gln Lys Gly Ser Leu Gly Glu 
545                 550                 555                 560 


Ala Gly Ala Pro Gly His Lys Gly Ser Lys Gly Ala Pro Gly Pro Ala 
                565                 570                 575     


Gly Ala Arg Gly Glu Ser Gly Leu Ala Gly Ala Pro Gly Pro Ala Gly 
            580                 585                 590         


Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Gly Leu Pro 
        595                 600                 605             


Ala Gly Phe Asp Asp Met Glu Gly Ser Gly Gly Pro Phe Trp Ser Thr 
    610                 615                 620                 


Ala Arg Ser Ala Asp Gly Pro Gln Gly Pro Pro Gly Leu Pro Gly Leu 
625                 630                 635                 640 


Lys Gly Asp Pro Gly Val Pro Gly Leu Pro Gly Ala Lys Gly Glu Val 
                645                 650                 655     


Gly Ala Asp Gly Val Pro Gly Phe Pro Gly Leu Pro Gly Arg Glu Gly 
            660                 665                 670         


Ile Ala Gly Pro Gln Gly Pro Lys Gly Asp Arg Gly Ser Arg Gly Glu 
        675                 680                 685             


Lys Gly Asp Pro Gly Lys Asp Gly Val Gly Gln Pro Gly Leu Pro Gly 
    690                 695                 700                 


Pro Pro Gly Pro Pro Gly Pro Val Val Tyr Val Ser Glu Gln Asp Gly 
705                 710                 715                 720 


Ser Val Leu Ser Val Pro Gly Pro Glu Gly Arg Pro Gly Phe Ala Gly 
                725                 730                 735     


Phe Pro Gly Pro Ala Gly Pro Lys Gly Asn Leu Gly Ser Lys Gly Glu 
            740                 745                 750         


Arg Gly Ser Pro Gly Pro Lys Gly Glu Lys Gly Glu Pro Gly Ser Ile 
        755                 760                 765             


Phe Ser Pro Asp Gly Gly Ala Leu Gly Pro Ala Gln Lys Gly Ala Lys 
    770                 775                 780                 


Gly Glu Pro Gly Phe Arg Gly Pro Pro Gly Pro Tyr Gly Arg Pro Gly 
785                 790                 795                 800 


Tyr Lys Gly Glu Ile Gly Phe Pro Gly Arg Pro Gly Arg Pro Gly Met 
                805                 810                 815     


Asn Gly Leu Lys Gly Glu Lys Gly Glu Pro Gly Asp Ala Ser Leu Gly 
            820                 825                 830         


Phe Gly Met Arg Gly Met Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro 
        835                 840                 845             


Gly Pro Pro Gly Thr Pro Val Tyr Asp Ser Asn Val Phe Ala Glu Ser 
    850                 855                 860                 


Ser Arg Pro Gly Pro Pro Gly Leu Pro Gly Asn Gln Gly Pro Pro Gly 
865                 870                 875                 880 


Pro Lys Gly Ala Lys Gly Glu Val Gly Pro Pro Gly Pro Pro Gly Gln 
                885                 890                 895     


Phe Pro Phe Asp Phe Leu Gln Leu Glu Ala Glu Met Lys Gly Glu Lys 
            900                 905                 910         


Gly Asp Arg Gly Asp Ala Gly Gln Lys Gly Glu Arg Gly Glu Pro Gly 
        915                 920                 925             


Gly Gly Gly Phe Phe Gly Ser Ser Leu Pro Gly Pro Pro Gly Pro Pro 
    930                 935                 940                 


Gly Pro Pro Gly Pro Arg Gly Tyr Pro Gly Ile Pro Gly Pro Lys Gly 
945                 950                 955                 960 


Glu Ser Ile Arg Gly Gln Pro Gly Pro Pro Gly Pro Gln Gly Pro Pro 
                965                 970                 975     


Gly Ile Gly Tyr Glu Gly Arg Gln Gly Pro Pro Gly Pro Pro Gly Pro 
            980                 985                 990         


Pro Gly Pro Pro Ser Phe Pro Gly  Pro His Arg Gln Thr  Ile Ser Val 
        995                 1000                 1005             


Pro Gly  Pro Pro Gly Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Thr 
    1010                 1015                 1020             


Met Gly  Ala Ser Ser Gly Val  Arg Leu Trp Ala Thr  Arg Gln Ala 
    1025                 1030                 1035             


Met Leu  Gly Gln Val His Glu  Val Pro Glu Gly Trp  Leu Ile Phe 
    1040                 1045                 1050             


Val Ala  Glu Gln Glu Glu Leu  Tyr Val Arg Val Gln  Asn Gly Phe 
    1055                 1060                 1065             


Arg Lys  Val Gln Leu Glu Ala  Arg Thr Pro Leu Pro  Arg Gly Thr 
    1070                 1075                 1080             


Asp Asn  Glu Val Ala Ala Leu  Gln Pro Pro Val Val  Gln Leu His 
    1085                 1090                 1095             


Asp Ser  Asn Pro Tyr Pro Arg  Arg Glu His Pro His  Pro Thr Ala 
    1100                 1105                 1110             


Arg Pro  Trp Arg Ala Asp Asp  Ile Leu Ala Ser Pro  Pro Arg Leu 
    1115                 1120                 1125             


Pro Glu  Pro Gln Pro Tyr Pro  Gly Ala Pro His His  Ser Ser Tyr 
    1130                 1135                 1140             


Val His  Leu Arg Pro Ala Arg  Pro Thr Ser Pro Pro  Ala His Ser 
    1145                 1150                 1155             


His Arg  Asp Phe Gln Pro Val  Leu His Leu Val Ala  Leu Asn Ser 
    1160                 1165                 1170             


Pro Leu  Ser Gly Gly Met Arg  Gly Ile Arg Gly Ala  Asp Phe Gln 
    1175                 1180                 1185             


Cys Phe  Gln Gln Ala Arg Ala  Val Gly Leu Ala Gly  Thr Phe Arg 
    1190                 1195                 1200             


Ala Phe  Leu Ser Ser Arg Leu  Gln Asp Leu Tyr Ser  Ile Val Arg 
    1205                 1210                 1215             


Arg Ala  Asp Arg Ala Ala Val  Pro Ile Val Asn Leu  Lys Asp Glu 
    1220                 1225                 1230             


Leu Leu  Phe Pro Ser Trp Glu  Ala Leu Phe Ser Gly  Ser Glu Gly 
    1235                 1240                 1245             


Pro Leu  Lys Pro Gly Ala Arg  Ile Phe Ser Phe Asp  Gly Lys Asp 
    1250                 1255                 1260             


Val Leu  Arg His Pro Thr Trp  Pro Gln Lys Ser Val  Trp His Gly 
    1265                 1270                 1275             


Ser Asp  Pro Asn Gly Arg Arg  Leu Thr Glu Ser Tyr  Cys Glu Thr 
    1280                 1285                 1290             


Trp Arg  Thr Glu Ala Pro Ser  Ala Thr Gly Gln Ala  Ser Ser Leu 
    1295                 1300                 1305             


Leu Gly  Gly Arg Leu Leu Gly  Gln Ser Ala Ala Ser  Cys His His 
    1310                 1315                 1320             


Ala Tyr  Ile Val Leu Cys Ile  Glu Asn Ser Phe Met  Thr Ala Ser 
    1325                 1330                 1335             


Lys 
    


<210>  3248
<211>  1519
<212>  PRT
<213>  Homo Sapiens

<400>  3248

Met Ala Pro Tyr Pro Cys Gly Cys His Ile Leu Leu Leu Leu Phe Cys 
1               5                   10                  15      


Cys Leu Ala Ala Ala Arg Ala Asn Leu Leu Asn Leu Asn Trp Leu Trp 
            20                  25                  30          


Phe Asn Asn Glu Asp Thr Ser His Ala Ala Thr Thr Ile Pro Glu Pro 
        35                  40                  45              


Gln Gly Pro Leu Pro Val Gln Pro Thr Ala Asp Thr Thr Thr His Val 
    50                  55                  60                  


Thr Pro Arg Asn Gly Ser Thr Glu Pro Ala Thr Ala Pro Gly Ser Pro 
65                  70                  75                  80  


Glu Pro Pro Ser Glu Leu Leu Glu Asp Gly Gln Asp Thr Pro Thr Ser 
                85                  90                  95      


Ala Glu Ser Pro Asp Ala Pro Glu Glu Asn Ile Ala Gly Val Gly Ala 
            100                 105                 110         


Glu Ile Leu Asn Val Ala Lys Gly Ile Arg Ser Phe Val Gln Leu Trp 
        115                 120                 125             


Asn Asp Thr Val Pro Thr Glu Ser Leu Ala Arg Ala Glu Thr Leu Val 
    130                 135                 140                 


Leu Glu Thr Pro Val Gly Pro Leu Ala Leu Ala Gly Pro Ser Ser Thr 
145                 150                 155                 160 


Pro Gln Glu Asn Gly Thr Thr Leu Trp Pro Ser Arg Gly Ile Pro Ser 
                165                 170                 175     


Ser Pro Gly Ala His Thr Thr Glu Ala Gly Thr Leu Pro Ala Pro Thr 
            180                 185                 190         


Pro Ser Pro Pro Ser Leu Gly Arg Pro Trp Ala Pro Leu Thr Gly Pro 
        195                 200                 205             


Ser Val Pro Pro Pro Ser Ser Glu Arg Ile Ser Glu Glu Val Gly Leu 
    210                 215                 220                 


Leu Gln Leu Leu Gly Asp Pro Pro Pro Gln Gln Val Thr Gln Thr Asp 
225                 230                 235                 240 


Asp Pro Asp Val Gly Leu Ala Tyr Val Phe Gly Pro Asp Ala Asn Ser 
                245                 250                 255     


Gly Gln Val Ala Arg Tyr His Phe Pro Ser Leu Phe Phe Arg Asp Phe 
            260                 265                 270         


Ser Leu Leu Phe His Ile Arg Pro Ala Thr Glu Gly Pro Gly Val Leu 
        275                 280                 285             


Phe Ala Ile Thr Asp Ser Ala Gln Ala Met Val Leu Leu Gly Val Lys 
    290                 295                 300                 


Leu Ser Gly Val Gln Asp Gly His Gln Asp Ile Ser Leu Leu Tyr Thr 
305                 310                 315                 320 


Glu Pro Gly Ala Gly Gln Thr His Thr Ala Ala Ser Phe Arg Leu Pro 
                325                 330                 335     


Ala Phe Val Gly Gln Trp Thr His Leu Ala Leu Ser Val Ala Gly Gly 
            340                 345                 350         


Phe Val Ala Leu Tyr Val Asp Cys Glu Glu Phe Gln Arg Met Pro Leu 
        355                 360                 365             


Ala Arg Ser Ser Arg Gly Leu Glu Leu Glu Pro Gly Ala Gly Leu Phe 
    370                 375                 380                 


Val Ala Gln Ala Gly Gly Ala Asp Pro Asp Lys Phe Gln Gly Val Ile 
385                 390                 395                 400 


Ala Glu Leu Lys Val Arg Arg Asp Pro Gln Val Ser Pro Met His Cys 
                405                 410                 415     


Leu Asp Glu Glu Gly Asp Asp Ser Asp Gly Ala Ser Gly Asp Ser Gly 
            420                 425                 430         


Ser Gly Leu Gly Asp Ala Arg Glu Leu Leu Arg Glu Glu Thr Gly Ala 
        435                 440                 445             


Ala Leu Lys Pro Arg Leu Pro Ala Pro Pro Pro Val Thr Thr Pro Pro 
    450                 455                 460                 


Leu Ala Gly Gly Ser Ser Thr Glu Asp Ser Arg Ser Glu Glu Val Glu 
465                 470                 475                 480 


Glu Gln Thr Thr Val Ala Ser Leu Gly Ala Gln Thr Leu Pro Gly Ser 
                485                 490                 495     


Asp Ser Val Ser Thr Trp Asp Gly Ser Val Arg Thr Pro Gly Gly Arg 
            500                 505                 510         


Val Lys Glu Gly Gly Leu Lys Gly Gln Lys Gly Glu Pro Gly Val Pro 
        515                 520                 525             


Gly Pro Pro Gly Arg Ala Gly Pro Pro Gly Ser Pro Cys Leu Pro Gly 
    530                 535                 540                 


Pro Pro Gly Leu Pro Cys Pro Val Ser Pro Leu Gly Pro Ala Gly Pro 
545                 550                 555                 560 


Ala Leu Gln Thr Val Pro Gly Pro Gln Gly Pro Pro Gly Pro Pro Gly 
                565                 570                 575     


Arg Asp Gly Thr Pro Gly Arg Asp Gly Glu Pro Gly Asp Pro Gly Glu 
            580                 585                 590         


Asp Gly Lys Pro Gly Asp Thr Gly Pro Gln Gly Phe Pro Gly Thr Pro 
        595                 600                 605             


Gly Asp Val Gly Pro Lys Gly Asp Lys Gly Asp Pro Gly Val Gly Glu 
    610                 615                 620                 


Arg Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly Pro Pro Gly Pro Ser 
625                 630                 635                 640 


Phe Arg His Asp Lys Leu Thr Phe Ile Asp Met Glu Gly Ser Gly Phe 
                645                 650                 655     


Gly Gly Asp Leu Glu Ala Leu Arg Gly Pro Arg Gly Phe Pro Gly Pro 
            660                 665                 670         


Pro Gly Pro Pro Gly Val Pro Gly Leu Pro Gly Glu Pro Gly Arg Phe 
        675                 680                 685             


Gly Val Asn Ser Ser Asp Val Pro Gly Pro Ala Gly Leu Pro Gly Val 
    690                 695                 700                 


Pro Gly Arg Glu Gly Pro Pro Gly Phe Pro Gly Leu Pro Gly Pro Pro 
705                 710                 715                 720 


Gly Pro Pro Gly Arg Glu Gly Pro Pro Gly Arg Thr Gly Gln Lys Gly 
                725                 730                 735     


Ser Leu Gly Glu Ala Gly Ala Pro Gly His Lys Gly Ser Lys Gly Ala 
            740                 745                 750         


Pro Gly Pro Ala Gly Ala Arg Gly Glu Ser Gly Leu Ala Gly Ala Pro 
        755                 760                 765             


Gly Pro Ala Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
    770                 775                 780                 


Pro Gly Leu Pro Ala Gly Phe Asp Asp Met Glu Gly Ser Gly Gly Pro 
785                 790                 795                 800 


Phe Trp Ser Thr Ala Arg Ser Ala Asp Gly Pro Gln Gly Pro Pro Gly 
                805                 810                 815     


Leu Pro Gly Leu Lys Gly Asp Pro Gly Val Pro Gly Leu Pro Gly Ala 
            820                 825                 830         


Lys Gly Glu Val Gly Ala Asp Gly Val Pro Gly Phe Pro Gly Leu Pro 
        835                 840                 845             


Gly Arg Glu Gly Ile Ala Gly Pro Gln Gly Pro Lys Gly Asp Arg Gly 
    850                 855                 860                 


Ser Arg Gly Glu Lys Gly Asp Pro Gly Lys Asp Gly Val Gly Gln Pro 
865                 870                 875                 880 


Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Pro Val Val Tyr Val Ser 
                885                 890                 895     


Glu Gln Asp Gly Ser Val Leu Ser Val Pro Gly Pro Glu Gly Arg Pro 
            900                 905                 910         


Gly Phe Ala Gly Phe Pro Gly Pro Ala Gly Pro Lys Gly Asn Leu Gly 
        915                 920                 925             


Ser Lys Gly Glu Arg Gly Ser Pro Gly Pro Lys Gly Glu Lys Gly Glu 
    930                 935                 940                 


Pro Gly Ser Ile Phe Ser Pro Asp Gly Gly Ala Leu Gly Pro Ala Gln 
945                 950                 955                 960 


Lys Gly Ala Lys Gly Glu Pro Gly Phe Arg Gly Pro Pro Gly Pro Tyr 
                965                 970                 975     


Gly Arg Pro Gly Tyr Lys Gly Glu Ile Gly Phe Pro Gly Arg Pro Gly 
            980                 985                 990         


Arg Pro Gly Met Asn Gly Leu Lys  Gly Glu Lys Gly Glu  Pro Gly Asp 
        995                 1000                 1005             


Ala Ser  Leu Gly Phe Gly Met  Arg Gly Met Pro Gly  Pro Pro Gly 
    1010                 1015                 1020             


Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Thr Pro Val  Tyr Asp Ser 
    1025                 1030                 1035             


Asn Val  Phe Ala Glu Ser Ser  Arg Pro Gly Pro Pro  Gly Leu Pro 
    1040                 1045                 1050             


Gly Asn  Gln Gly Pro Pro Gly  Pro Lys Gly Ala Lys  Gly Glu Val 
    1055                 1060                 1065             


Gly Pro  Pro Gly Pro Pro Gly  Gln Phe Pro Phe Asp  Phe Leu Gln 
    1070                 1075                 1080             


Leu Glu  Ala Glu Met Lys Gly  Glu Lys Gly Asp Arg  Gly Asp Ala 
    1085                 1090                 1095             


Gly Gln  Lys Gly Glu Arg Gly  Glu Pro Gly Gly Gly  Gly Phe Phe 
    1100                 1105                 1110             


Gly Ser  Ser Leu Pro Gly Pro  Pro Gly Pro Pro Gly  Pro Pro Gly 
    1115                 1120                 1125             


Pro Arg  Gly Tyr Pro Gly Ile  Pro Gly Pro Lys Gly  Glu Ser Ile 
    1130                 1135                 1140             


Arg Gly  Gln Pro Gly Pro Pro  Gly Pro Gln Gly Pro  Pro Gly Ile 
    1145                 1150                 1155             


Gly Tyr  Glu Gly Arg Gln Gly  Pro Pro Gly Pro Pro  Gly Pro Pro 
    1160                 1165                 1170             


Gly Pro  Pro Ser Phe Pro Gly  Pro His Arg Gln Thr  Ile Ser Val 
    1175                 1180                 1185             


Pro Gly  Pro Pro Gly Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Thr 
    1190                 1195                 1200             


Met Gly  Ala Ser Ser Gly Val  Arg Leu Trp Ala Thr  Arg Gln Ala 
    1205                 1210                 1215             


Met Leu  Gly Gln Val His Glu  Val Pro Glu Gly Trp  Leu Ile Phe 
    1220                 1225                 1230             


Val Ala  Glu Gln Glu Glu Leu  Tyr Val Arg Val Gln  Asn Gly Phe 
    1235                 1240                 1245             


Arg Lys  Val Gln Leu Glu Ala  Arg Thr Pro Leu Pro  Arg Gly Thr 
    1250                 1255                 1260             


Asp Asn  Glu Val Ala Ala Leu  Gln Pro Pro Val Val  Gln Leu His 
    1265                 1270                 1275             


Asp Ser  Asn Pro Tyr Pro Arg  Arg Glu His Pro His  Pro Thr Ala 
    1280                 1285                 1290             


Arg Pro  Trp Arg Ala Asp Asp  Ile Leu Ala Ser Pro  Pro Arg Leu 
    1295                 1300                 1305             


Pro Glu  Pro Gln Pro Tyr Pro  Gly Ala Pro His His  Ser Ser Tyr 
    1310                 1315                 1320             


Val His  Leu Arg Pro Ala Arg  Pro Thr Ser Pro Pro  Ala His Ser 
    1325                 1330                 1335             


His Arg  Asp Phe Gln Pro Val  Leu His Leu Val Ala  Leu Asn Ser 
    1340                 1345                 1350             


Pro Leu  Ser Gly Gly Met Arg  Gly Ile Arg Gly Ala  Asp Phe Gln 
    1355                 1360                 1365             


Cys Phe  Gln Gln Ala Arg Ala  Val Gly Leu Ala Gly  Thr Phe Arg 
    1370                 1375                 1380             


Ala Phe  Leu Ser Ser Arg Leu  Gln Asp Leu Tyr Ser  Ile Val Arg 
    1385                 1390                 1395             


Arg Ala  Asp Arg Ala Ala Val  Pro Ile Val Asn Leu  Lys Asp Glu 
    1400                 1405                 1410             


Leu Leu  Phe Pro Ser Trp Glu  Ala Leu Phe Ser Gly  Ser Glu Gly 
    1415                 1420                 1425             


Pro Leu  Lys Pro Gly Ala Arg  Ile Phe Ser Phe Asp  Gly Lys Asp 
    1430                 1435                 1440             


Val Leu  Arg His Pro Thr Trp  Pro Gln Lys Ser Val  Trp His Gly 
    1445                 1450                 1455             


Ser Asp  Pro Asn Gly Arg Arg  Leu Thr Glu Ser Tyr  Cys Glu Thr 
    1460                 1465                 1470             


Trp Arg  Thr Glu Ala Pro Ser  Ala Thr Gly Gln Ala  Ser Ser Leu 
    1475                 1480                 1485             


Leu Gly  Gly Arg Leu Leu Gly  Gln Ser Ala Ala Ser  Cys His His 
    1490                 1495                 1500             


Ala Tyr  Ile Val Leu Cys Ile  Glu Asn Ser Phe Met  Thr Ala Ser 
    1505                 1510                 1515             


Lys 
    


<210>  3249
<211>  1754
<212>  PRT
<213>  Homo Sapiens

<400>  3249

Met Ala Pro Tyr Pro Cys Gly Cys His Ile Leu Leu Leu Leu Phe Cys 
1               5                   10                  15      


Cys Leu Ala Ala Ala Arg Ala Asn Leu Leu Asn Leu Asn Trp Leu Trp 
            20                  25                  30          


Phe Asn Asn Glu Asp Thr Ser His Ala Ala Thr Thr Ile Pro Glu Pro 
        35                  40                  45              


Gln Gly Pro Leu Pro Val Gln Pro Thr Ala Asp Thr Thr Thr His Val 
    50                  55                  60                  


Thr Pro Arg Asn Gly Ser Thr Glu Pro Ala Thr Ala Pro Gly Ser Pro 
65                  70                  75                  80  


Glu Pro Pro Ser Glu Leu Leu Glu Asp Gly Gln Asp Thr Pro Thr Ser 
                85                  90                  95      


Ala Glu Ser Pro Asp Ala Pro Glu Glu Asn Ile Ala Gly Val Gly Ala 
            100                 105                 110         


Glu Ile Leu Asn Val Ala Lys Gly Ile Arg Ser Phe Val Gln Leu Trp 
        115                 120                 125             


Asn Asp Thr Val Pro Thr Glu Ser Leu Ala Arg Ala Glu Thr Leu Val 
    130                 135                 140                 


Leu Glu Thr Pro Val Gly Pro Leu Ala Leu Ala Gly Pro Ser Ser Thr 
145                 150                 155                 160 


Pro Gln Glu Asn Gly Thr Thr Leu Trp Pro Ser Arg Gly Ile Pro Ser 
                165                 170                 175     


Ser Pro Gly Ala His Thr Thr Glu Ala Gly Thr Leu Pro Ala Pro Thr 
            180                 185                 190         


Pro Ser Pro Pro Ser Leu Gly Arg Pro Trp Ala Pro Leu Thr Gly Pro 
        195                 200                 205             


Ser Val Pro Pro Pro Ser Ser Gly Arg Ala Ser Leu Ser Ser Leu Leu 
    210                 215                 220                 


Gly Gly Ala Pro Pro Trp Gly Ser Leu Gln Asp Pro Asp Ser Gln Gly 
225                 230                 235                 240 


Leu Ser Pro Ala Ala Ala Ala Pro Ser Gln Gln Leu Gln Arg Pro Asp 
                245                 250                 255     


Val Arg Leu Arg Thr Pro Leu Leu His Pro Leu Val Met Gly Ser Leu 
            260                 265                 270         


Gly Lys His Ala Ala Pro Ser Ala Phe Ser Ser Gly Leu Pro Gly Ala 
        275                 280                 285             


Leu Ser Gln Val Ala Val Thr Thr Leu Thr Arg Asp Ser Gly Ala Trp 
    290                 295                 300                 


Val Ser His Val Ala Asn Ser Val Gly Pro Gly Leu Ala Asn Asn Ser 
305                 310                 315                 320 


Ala Leu Leu Gly Ala Asp Pro Glu Ala Pro Ala Gly Arg Cys Leu Pro 
                325                 330                 335     


Leu Pro Pro Ser Leu Pro Val Cys Gly His Leu Gly Ile Ser Arg Phe 
            340                 345                 350         


Trp Leu Pro Asn His Leu His His Glu Ser Gly Glu Gln Val Arg Ala 
        355                 360                 365             


Gly Ala Arg Ala Trp Gly Gly Leu Leu Gln Thr His Cys His Pro Phe 
    370                 375                 380                 


Leu Ala Trp Phe Phe Cys Leu Leu Leu Val Pro Pro Cys Gly Ser Val 
385                 390                 395                 400 


Pro Pro Pro Ala Pro Pro Pro Cys Cys Gln Phe Cys Glu Ala Leu Gln 
                405                 410                 415     


Asp Ala Cys Trp Ser Arg Leu Gly Gly Gly Arg Leu Pro Val Ala Cys 
            420                 425                 430         


Ala Ser Leu Pro Thr Gln Glu Asp Gly Tyr Cys Val Leu Ile Gly Pro 
        435                 440                 445             


Ala Ala Glu Arg Ile Ser Glu Glu Val Gly Leu Leu Gln Leu Leu Gly 
    450                 455                 460                 


Asp Pro Pro Pro Gln Gln Val Thr Gln Thr Asp Asp Pro Asp Val Gly 
465                 470                 475                 480 


Leu Ala Tyr Val Phe Gly Pro Asp Ala Asn Ser Gly Gln Val Ala Arg 
                485                 490                 495     


Tyr His Phe Pro Ser Leu Phe Phe Arg Asp Phe Ser Leu Leu Phe His 
            500                 505                 510         


Ile Arg Pro Ala Thr Glu Gly Pro Gly Val Leu Phe Ala Ile Thr Asp 
        515                 520                 525             


Ser Ala Gln Ala Met Val Leu Leu Gly Val Lys Leu Ser Gly Val Gln 
    530                 535                 540                 


Asp Gly His Gln Asp Ile Ser Leu Leu Tyr Thr Glu Pro Gly Ala Gly 
545                 550                 555                 560 


Gln Thr His Thr Ala Ala Ser Phe Arg Leu Pro Ala Phe Val Gly Gln 
                565                 570                 575     


Trp Thr His Leu Ala Leu Ser Val Ala Gly Gly Phe Val Ala Leu Tyr 
            580                 585                 590         


Val Asp Cys Glu Glu Phe Gln Arg Met Pro Leu Ala Arg Ser Ser Arg 
        595                 600                 605             


Gly Leu Glu Leu Glu Pro Gly Ala Gly Leu Phe Val Ala Gln Ala Gly 
    610                 615                 620                 


Gly Ala Asp Pro Asp Lys Phe Gln Gly Val Ile Ala Glu Leu Lys Val 
625                 630                 635                 640 


Arg Arg Asp Pro Gln Val Ser Pro Met His Cys Leu Asp Glu Glu Gly 
                645                 650                 655     


Asp Asp Ser Asp Gly Ala Ser Gly Asp Ser Gly Ser Gly Leu Gly Asp 
            660                 665                 670         


Ala Arg Glu Leu Leu Arg Glu Glu Thr Gly Ala Ala Leu Lys Pro Arg 
        675                 680                 685             


Leu Pro Ala Pro Pro Pro Val Thr Thr Pro Pro Leu Ala Gly Gly Ser 
    690                 695                 700                 


Ser Thr Glu Asp Ser Arg Ser Glu Glu Val Glu Glu Gln Thr Thr Val 
705                 710                 715                 720 


Ala Ser Leu Gly Ala Gln Thr Leu Pro Gly Ser Asp Ser Val Ser Thr 
                725                 730                 735     


Trp Asp Gly Ser Val Arg Thr Pro Gly Gly Arg Val Lys Glu Gly Gly 
            740                 745                 750         


Leu Lys Gly Gln Lys Gly Glu Pro Gly Val Pro Gly Pro Pro Gly Arg 
        755                 760                 765             


Ala Gly Pro Pro Gly Ser Pro Cys Leu Pro Gly Pro Pro Gly Leu Pro 
    770                 775                 780                 


Cys Pro Val Ser Pro Leu Gly Pro Ala Gly Pro Ala Leu Gln Thr Val 
785                 790                 795                 800 


Pro Gly Pro Gln Gly Pro Pro Gly Pro Pro Gly Arg Asp Gly Thr Pro 
                805                 810                 815     


Gly Arg Asp Gly Glu Pro Gly Asp Pro Gly Glu Asp Gly Lys Pro Gly 
            820                 825                 830         


Asp Thr Gly Pro Gln Gly Phe Pro Gly Thr Pro Gly Asp Val Gly Pro 
        835                 840                 845             


Lys Gly Asp Lys Gly Asp Pro Gly Val Gly Glu Arg Gly Pro Pro Gly 
    850                 855                 860                 


Pro Gln Gly Pro Pro Gly Pro Pro Gly Pro Ser Phe Arg His Asp Lys 
865                 870                 875                 880 


Leu Thr Phe Ile Asp Met Glu Gly Ser Gly Phe Gly Gly Asp Leu Glu 
                885                 890                 895     


Ala Leu Arg Gly Pro Arg Gly Phe Pro Gly Pro Pro Gly Pro Pro Gly 
            900                 905                 910         


Val Pro Gly Leu Pro Gly Glu Pro Gly Arg Phe Gly Val Asn Ser Ser 
        915                 920                 925             


Asp Val Pro Gly Pro Ala Gly Leu Pro Gly Val Pro Gly Arg Glu Gly 
    930                 935                 940                 


Pro Pro Gly Phe Pro Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Arg 
945                 950                 955                 960 


Glu Gly Pro Pro Gly Arg Thr Gly Gln Lys Gly Ser Leu Gly Glu Ala 
                965                 970                 975     


Gly Ala Pro Gly His Lys Gly Ser Lys Gly Ala Pro Gly Pro Ala Gly 
            980                 985                 990         


Ala Arg Gly Glu Ser Gly Leu Ala  Gly Ala Pro Gly Pro  Ala Gly Pro 
        995                 1000                 1005             


Pro Gly  Pro Pro Gly Pro Pro  Gly Pro Pro Gly Pro  Gly Leu Pro 
    1010                 1015                 1020             


Ala Gly  Phe Asp Asp Met Glu  Gly Ser Gly Gly Pro  Phe Trp Ser 
    1025                 1030                 1035             


Thr Ala  Arg Ser Ala Asp Gly  Pro Gln Gly Pro Pro  Gly Leu Pro 
    1040                 1045                 1050             


Gly Leu  Lys Gly Asp Pro Gly  Val Pro Gly Leu Pro  Gly Ala Lys 
    1055                 1060                 1065             


Gly Glu  Val Gly Ala Asp Gly  Val Pro Gly Phe Pro  Gly Leu Pro 
    1070                 1075                 1080             


Gly Arg  Glu Gly Ile Ala Gly  Pro Gln Gly Pro Lys  Gly Asp Arg 
    1085                 1090                 1095             


Gly Ser  Arg Gly Glu Lys Gly  Asp Pro Gly Lys Asp  Gly Val Gly 
    1100                 1105                 1110             


Gln Pro  Gly Leu Pro Gly Pro  Pro Gly Pro Pro Gly  Pro Val Val 
    1115                 1120                 1125             


Tyr Val  Ser Glu Gln Asp Gly  Ser Val Leu Ser Val  Pro Gly Pro 
    1130                 1135                 1140             


Glu Gly  Arg Pro Gly Phe Ala  Gly Phe Pro Gly Pro  Ala Gly Pro 
    1145                 1150                 1155             


Lys Gly  Asn Leu Gly Ser Lys  Gly Glu Arg Gly Ser  Pro Gly Pro 
    1160                 1165                 1170             


Lys Gly  Glu Lys Gly Glu Pro  Gly Ser Ile Phe Ser  Pro Asp Gly 
    1175                 1180                 1185             


Gly Ala  Leu Gly Pro Ala Gln  Lys Gly Ala Lys Gly  Glu Pro Gly 
    1190                 1195                 1200             


Phe Arg  Gly Pro Pro Gly Pro  Tyr Gly Arg Pro Gly  Tyr Lys Gly 
    1205                 1210                 1215             


Glu Ile  Gly Phe Pro Gly Arg  Pro Gly Arg Pro Gly  Met Asn Gly 
    1220                 1225                 1230             


Leu Lys  Gly Glu Lys Gly Glu  Pro Gly Asp Ala Ser  Leu Gly Phe 
    1235                 1240                 1245             


Gly Met  Arg Gly Met Pro Gly  Pro Pro Gly Pro Pro  Gly Pro Pro 
    1250                 1255                 1260             


Gly Pro  Pro Gly Thr Pro Val  Tyr Asp Ser Asn Val  Phe Ala Glu 
    1265                 1270                 1275             


Ser Ser  Arg Pro Gly Pro Pro  Gly Leu Pro Gly Asn  Gln Gly Pro 
    1280                 1285                 1290             


Pro Gly  Pro Lys Gly Ala Lys  Gly Glu Val Gly Pro  Pro Gly Pro 
    1295                 1300                 1305             


Pro Gly  Gln Phe Pro Phe Asp  Phe Leu Gln Leu Glu  Ala Glu Met 
    1310                 1315                 1320             


Lys Gly  Glu Lys Gly Asp Arg  Gly Asp Ala Gly Gln  Lys Gly Glu 
    1325                 1330                 1335             


Arg Gly  Glu Pro Gly Gly Gly  Gly Phe Phe Gly Ser  Ser Leu Pro 
    1340                 1345                 1350             


Gly Pro  Pro Gly Pro Pro Gly  Pro Pro Gly Pro Arg  Gly Tyr Pro 
    1355                 1360                 1365             


Gly Ile  Pro Gly Pro Lys Gly  Glu Ser Ile Arg Gly  Gln Pro Gly 
    1370                 1375                 1380             


Pro Pro  Gly Pro Gln Gly Pro  Pro Gly Ile Gly Tyr  Glu Gly Arg 
    1385                 1390                 1395             


Gln Gly  Pro Pro Gly Pro Pro  Gly Pro Pro Gly Pro  Pro Ser Phe 
    1400                 1405                 1410             


Pro Gly  Pro His Arg Gln Thr  Ile Ser Val Pro Gly  Pro Pro Gly 
    1415                 1420                 1425             


Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Thr Met Gly  Ala Ser Ser 
    1430                 1435                 1440             


Gly Val  Arg Leu Trp Ala Thr  Arg Gln Ala Met Leu  Gly Gln Val 
    1445                 1450                 1455             


His Glu  Val Pro Glu Gly Trp  Leu Ile Phe Val Ala  Glu Gln Glu 
    1460                 1465                 1470             


Glu Leu  Tyr Val Arg Val Gln  Asn Gly Phe Arg Lys  Val Gln Leu 
    1475                 1480                 1485             


Glu Ala  Arg Thr Pro Leu Pro  Arg Gly Thr Asp Asn  Glu Val Ala 
    1490                 1495                 1500             


Ala Leu  Gln Pro Pro Val Val  Gln Leu His Asp Ser  Asn Pro Tyr 
    1505                 1510                 1515             


Pro Arg  Arg Glu His Pro His  Pro Thr Ala Arg Pro  Trp Arg Ala 
    1520                 1525                 1530             


Asp Asp  Ile Leu Ala Ser Pro  Pro Arg Leu Pro Glu  Pro Gln Pro 
    1535                 1540                 1545             


Tyr Pro  Gly Ala Pro His His  Ser Ser Tyr Val His  Leu Arg Pro 
    1550                 1555                 1560             


Ala Arg  Pro Thr Ser Pro Pro  Ala His Ser His Arg  Asp Phe Gln 
    1565                 1570                 1575             


Pro Val  Leu His Leu Val Ala  Leu Asn Ser Pro Leu  Ser Gly Gly 
    1580                 1585                 1590             


Met Arg  Gly Ile Arg Gly Ala  Asp Phe Gln Cys Phe  Gln Gln Ala 
    1595                 1600                 1605             


Arg Ala  Val Gly Leu Ala Gly  Thr Phe Arg Ala Phe  Leu Ser Ser 
    1610                 1615                 1620             


Arg Leu  Gln Asp Leu Tyr Ser  Ile Val Arg Arg Ala  Asp Arg Ala 
    1625                 1630                 1635             


Ala Val  Pro Ile Val Asn Leu  Lys Asp Glu Leu Leu  Phe Pro Ser 
    1640                 1645                 1650             


Trp Glu  Ala Leu Phe Ser Gly  Ser Glu Gly Pro Leu  Lys Pro Gly 
    1655                 1660                 1665             


Ala Arg  Ile Phe Ser Phe Asp  Gly Lys Asp Val Leu  Arg His Pro 
    1670                 1675                 1680             


Thr Trp  Pro Gln Lys Ser Val  Trp His Gly Ser Asp  Pro Asn Gly 
    1685                 1690                 1695             


Arg Arg  Leu Thr Glu Ser Tyr  Cys Glu Thr Trp Arg  Thr Glu Ala 
    1700                 1705                 1710             


Pro Ser  Ala Thr Gly Gln Ala  Ser Ser Leu Leu Gly  Gly Arg Leu 
    1715                 1720                 1725             


Leu Gly  Gln Ser Ala Ala Ser  Cys His His Ala Tyr  Ile Val Leu 
    1730                 1735                 1740             


Cys Ile  Glu Asn Ser Phe Met  Thr Ala Ser Lys 
    1745                 1750                 


<210>  3250
<211>  280
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3250

Xaa Ile Ser Val Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro 
1               5                   10                  15      


Pro Gly Thr Met Gly Ala Ser Ser Gly Val Arg Leu Trp Ala Thr Arg 
            20                  25                  30          


Gln Ala Met Leu Gly Gln Val His Glu Val Pro Glu Gly Trp Leu Ile 
        35                  40                  45              


Phe Val Ala Glu Gln Glu Glu Leu Tyr Val Arg Val Gln Asn Gly Phe 
    50                  55                  60                  


Arg Lys Val Gln Asp Asn Glu Val Ala Ala Leu Gln Pro Pro Val Val 
65                  70                  75                  80  


Gln Leu His Asp Ser Asn Pro Tyr Pro Arg Arg Glu His Pro His Pro 
                85                  90                  95      


Thr Ala Arg Pro Trp Arg Ala Asp Asp Ile Leu Ala Ser Pro Pro Arg 
            100                 105                 110         


Leu Pro Glu Pro Gln Pro Tyr Pro Gly Ala Pro His His Ser Ser Tyr 
        115                 120                 125             


Val His Leu Arg Pro Ala Arg Pro Thr Ser Pro Pro Ala His Ser His 
    130                 135                 140                 


Arg Asp Phe Gln Pro Val Leu His Leu Val Ala Leu Asn Ser Pro Leu 
145                 150                 155                 160 


Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln Cys Phe Gln 
                165                 170                 175     


Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala Phe Leu Ser 
            180                 185                 190         


Ser Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala Asp Arg Ala 
        195                 200                 205             


Ala Val Pro Ile Val Asn Leu Lys Asp Glu Leu Leu Phe Pro Ser Trp 
    210                 215                 220                 


Glu Ala Leu Phe Ser Gly Ser Glu Gly Pro Leu Lys Pro Gly Ala Arg 
225                 230                 235                 240 


Ile Phe Ser Phe Asp Gly Lys Asp Val Leu Arg His Pro Thr Trp Pro 
                245                 250                 255     


Gln Lys Ser Val Trp His Gly Ser Asp Pro Asn Gly Arg Arg Leu Thr 
            260                 265                 270         


Glu Ser Tyr Cys Glu Thr Trp Arg 
        275                 280 


<210>  3251
<211>  36
<212>  PRT
<213>  Homo Sapiens

<400>  3251

Gly Pro Pro Gly Ile Gln Gly Ile His Gln Thr Leu Gly Gly Tyr Tyr 
1               5                   10                  15      


Asn Lys Asp Asn Lys Gly Asn Asp Glu His Glu Ala Gly Gly Leu Lys 
            20                  25                  30          


Gly Asp Lys Val 
        35      


<210>  3252
<211>  1142
<212>  PRT
<213>  Homo Sapiens

<400>  3252

Met Arg Leu Thr Gly Pro Trp Lys Leu Trp Leu Trp Met Ser Ile Phe 
1               5                   10                  15      


Leu Leu Pro Ala Ser Thr Ser Val Thr Val Arg Asp Lys Thr Glu Glu 
            20                  25                  30          


Ser Cys Pro Ile Leu Arg Ile Glu Gly His Gln Leu Thr Tyr Asp Asn 
        35                  40                  45              


Ile Asn Lys Leu Glu Val Ser Gly Phe Asp Leu Gly Asp Ser Phe Ser 
    50                  55                  60                  


Leu Arg Arg Ala Phe Cys Glu Ser Asp Lys Thr Cys Phe Lys Leu Gly 
65                  70                  75                  80  


Ser Ala Leu Leu Ile Arg Asp Thr Ile Lys Ile Phe Pro Lys Gly Leu 
                85                  90                  95      


Pro Glu Glu Tyr Ser Val Ala Ala Met Phe Arg Val Arg Arg Asn Ala 
            100                 105                 110         


Lys Lys Glu Arg Trp Phe Leu Trp Gln Val Leu Asn Gln Gln Asn Ile 
        115                 120                 125             


Pro Gln Ile Ser Ile Val Val Asp Gly Gly Lys Lys Val Val Glu Phe 
    130                 135                 140                 


Met Phe Gln Ala Thr Glu Gly Asp Val Leu Asn Tyr Ile Phe Arg Asn 
145                 150                 155                 160 


Arg Glu Leu Arg Pro Leu Phe Asp Arg Gln Trp His Lys Leu Gly Ile 
                165                 170                 175     


Ser Ile Gln Ser Gln Val Ile Ser Leu Tyr Met Asp Cys Asn Leu Ile 
            180                 185                 190         


Ala Arg Arg Gln Thr Asp Glu Lys Asp Thr Val Asp Phe His Gly Arg 
        195                 200                 205             


Thr Val Ile Ala Thr Arg Ala Ser Asp Gly Lys Pro Val Asp Ile Glu 
    210                 215                 220                 


Leu His Gln Leu Lys Ile Tyr Cys Ser Ala Asn Leu Ile Ala Gln Glu 
225                 230                 235                 240 


Thr Cys Cys Glu Ile Ser Asp Thr Lys Cys Pro Glu Gln Asp Gly Phe 
                245                 250                 255     


Gly Asn Ile Ala Ser Ser Trp Val Thr Ala His Ala Ser Lys Met Ser 
            260                 265                 270         


Ser Tyr Leu Pro Ala Lys Gln Glu Leu Lys Asp Gln Cys Gln Cys Ile 
        275                 280                 285             


Pro Asn Lys Gly Glu Ala Gly Leu Pro Gly Ala Pro Gly Ser Pro Gly 
    290                 295                 300                 


Gln Lys Gly His Lys Gly Glu Pro Gly Glu Asn Gly Leu His Gly Ala 
305                 310                 315                 320 


Pro Gly Phe Pro Gly Gln Lys Gly Glu Gln Gly Phe Glu Gly Ser Lys 
                325                 330                 335     


Gly Glu Thr Gly Glu Lys Gly Glu Gln Gly Glu Lys Gly Asp Pro Ala 
            340                 345                 350         


Leu Ala Gly Leu Asn Gly Glu Asn Gly Leu Lys Gly Asp Leu Gly Pro 
        355                 360                 365             


His Gly Pro Pro Gly Pro Lys Gly Glu Lys Gly Asp Thr Gly Pro Pro 
    370                 375                 380                 


Gly Pro Pro Ala Leu Pro Gly Ser Leu Gly Ile Gln Gly Pro Gln Gly 
385                 390                 395                 400 


Pro Pro Gly Lys Glu Gly Gln Arg Gly Arg Arg Gly Lys Thr Gly Pro 
                405                 410                 415     


Pro Gly Lys Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Ile Gln 
            420                 425                 430         


Gly Ile His Gln Thr Leu Gly Gly Tyr Tyr Asn Lys Asp Asn Lys Gly 
        435                 440                 445             


Asn Asp Glu His Glu Ala Gly Gly Leu Lys Gly Asp Lys Gly Glu Thr 
    450                 455                 460                 


Gly Leu Pro Gly Phe Pro Gly Ser Val Gly Pro Lys Gly Gln Lys Gly 
465                 470                 475                 480 


Glu Pro Gly Glu Pro Phe Thr Lys Gly Glu Lys Gly Asp Arg Gly Glu 
                485                 490                 495     


Pro Gly Val Ile Gly Ser Gln Gly Val Lys Gly Glu Pro Gly Asp Pro 
            500                 505                 510         


Gly Pro Pro Gly Leu Ile Gly Ser Pro Gly Leu Lys Gly Gln Gln Gly 
        515                 520                 525             


Ser Ala Gly Ser Met Gly Pro Arg Gly Pro Pro Gly Asp Val Gly Leu 
    530                 535                 540                 


Pro Gly Glu His Gly Ile Pro Gly Lys Gln Gly Ile Lys Gly Glu Lys 
545                 550                 555                 560 


Gly Asp Pro Gly Gly Ile Ile Gly Pro Pro Gly Leu Pro Gly Pro Lys 
                565                 570                 575     


Gly Glu Ala Gly Pro Pro Gly Lys Ser Leu Pro Gly Glu Pro Gly Leu 
            580                 585                 590         


Asp Gly Asn Pro Gly Ala Pro Gly Pro Arg Gly Pro Lys Gly Glu Arg 
        595                 600                 605             


Gly Leu Pro Gly Val His Gly Ser Pro Gly Asp Ile Gly Pro Gln Gly 
    610                 615                 620                 


Ile Gly Ile Pro Gly Arg Thr Gly Ala Gln Gly Pro Ala Gly Glu Pro 
625                 630                 635                 640 


Gly Ile Gln Gly Pro Arg Gly Leu Pro Gly Leu Pro Gly Thr Pro Gly 
                645                 650                 655     


Thr Pro Gly Asn Asp Gly Val Pro Gly Arg Asp Gly Lys Pro Gly Leu 
            660                 665                 670         


Pro Gly Pro Pro Gly Asp Pro Ile Ala Leu Pro Leu Leu Gly Asp Ile 
        675                 680                 685             


Gly Ala Leu Leu Lys Asn Phe Cys Gly Asn Cys Gln Ala Ser Val Pro 
    690                 695                 700                 


Gly Leu Lys Ser Asn Lys Gly Glu Glu Gly Gly Ala Gly Glu Pro Gly 
705                 710                 715                 720 


Lys Tyr Asp Ser Met Ala Arg Lys Gly Asp Ile Gly Pro Arg Gly Pro 
                725                 730                 735     


Pro Gly Ile Pro Gly Arg Glu Gly Pro Lys Gly Ser Lys Gly Glu Arg 
            740                 745                 750         


Gly Tyr Pro Gly Ile Pro Gly Glu Lys Gly Asp Glu Gly Leu Gln Gly 
        755                 760                 765             


Ile Pro Gly Ile Pro Gly Ala Pro Gly Pro Thr Gly Pro Pro Gly Leu 
    770                 775                 780                 


Met Gly Arg Thr Gly His Pro Gly Pro Thr Gly Ala Lys Gly Glu Lys 
785                 790                 795                 800 


Gly Ser Asp Gly Pro Pro Gly Lys Pro Gly Pro Pro Gly Pro Pro Gly 
                805                 810                 815     


Ile Pro Phe Asn Glu Arg Asn Gly Met Ser Ser Leu Tyr Lys Ile Lys 
            820                 825                 830         


Gly Gly Val Asn Val Pro Ser Tyr Pro Gly Pro Pro Gly Pro Pro Gly 
        835                 840                 845             


Pro Lys Gly Asp Pro Gly Pro Val Gly Glu Pro Gly Ala Met Gly Leu 
    850                 855                 860                 


Pro Gly Leu Glu Gly Phe Pro Gly Val Lys Gly Asp Arg Gly Pro Ala 
865                 870                 875                 880 


Gly Pro Pro Gly Ile Ala Gly Met Ser Gly Lys Pro Gly Ala Pro Gly 
                885                 890                 895     


Pro Pro Gly Val Pro Gly Glu Pro Gly Glu Arg Gly Pro Val Gly Asp 
            900                 905                 910         


Ile Gly Phe Pro Gly Pro Glu Gly Pro Ser Gly Lys Pro Gly Ile Asn 
        915                 920                 925             


Gly Lys Asp Gly Ile Pro Gly Ala Gln Gly Ile Met Gly Lys Pro Gly 
    930                 935                 940                 


Asp Arg Gly Pro Lys Gly Glu Arg Gly Asp Gln Gly Ile Pro Gly Asp 
945                 950                 955                 960 


Arg Gly Ser Gln Gly Glu Arg Gly Lys Pro Gly Leu Thr Gly Met Lys 
                965                 970                 975     


Gly Ala Ile Gly Pro Met Gly Pro Pro Gly Asn Lys Gly Ser Met Gly 
            980                 985                 990         


Ser Pro Gly His Gln Gly Pro Pro  Gly Ser Pro Gly Ile  Pro Gly Ile 
        995                 1000                 1005             


Pro Ala  Asp Ala Val Ser Phe  Glu Glu Ile Lys Lys  Tyr Ile Asn 
    1010                 1015                 1020             


Gln Glu  Val Leu Arg Ile Phe  Glu Glu Arg Met Ala  Val Phe Leu 
    1025                 1030                 1035             


Ser Gln  Leu Lys Leu Pro Ala  Ala Met Leu Ala Ala  Gln Ala Tyr 
    1040                 1045                 1050             


Gly Arg  Pro Gly Pro Pro Gly  Lys Asp Gly Leu Pro  Gly Pro Pro 
    1055                 1060                 1065             


Gly Asp  Pro Gly Pro Gln Gly  Tyr Arg Gly Gln Lys  Gly Glu Arg 
    1070                 1075                 1080             


Gly Glu  Pro Gly Ile Gly Leu  Pro Gly Ser Pro Gly  Leu Pro Gly 
    1085                 1090                 1095             


Thr Ser  Ala Leu Gly Leu Pro  Gly Ser Pro Gly Ala  Pro Gly Pro 
    1100                 1105                 1110             


Gln Gly  Pro Pro Gly Pro Ser  Gly Arg Cys Asn Pro  Glu Asp Cys 
    1115                 1120                 1125             


Leu Tyr  Pro Val Ser His Ala  His Gln Arg Thr Gly  Gly Asn 
    1130                 1135                 1140         


<210>  3253
<211>  60
<212>  PRT
<213>  Homo Sapiens

<400>  3253

Met Arg Leu Thr Gly Pro Trp Lys Leu Trp Leu Trp Met Ser Ile Phe 
1               5                   10                  15      


Leu Leu Pro Ala Ser Thr Ser Val Thr Val Arg Asp Lys Thr Gly Ile 
            20                  25                  30          


Gln Ala Asn Ser Leu Pro Asn His Gln Met Leu Phe Ile Ala Phe Lys 
        35                  40                  45              


Ser Leu Lys Gln Ile Leu Leu Arg Leu Lys Arg Pro 
    50                  55                  60  


<210>  3254
<211>  1464
<212>  PRT
<213>  Homo Sapiens

<400>  3254

Met Phe Ser Phe Val Asp Leu Arg Leu Leu Leu Leu Leu Ala Ala Thr 
1               5                   10                  15      


Ala Leu Leu Thr His Gly Gln Glu Glu Gly Gln Val Glu Gly Gln Asp 
            20                  25                  30          


Glu Asp Ile Pro Pro Ile Thr Cys Val Gln Asn Gly Leu Arg Tyr His 
        35                  40                  45              


Asp Arg Asp Val Trp Lys Pro Glu Pro Cys Arg Ile Cys Val Cys Asp 
    50                  55                  60                  


Asn Gly Lys Val Leu Cys Asp Asp Val Ile Cys Asp Glu Thr Lys Asn 
65                  70                  75                  80  


Cys Pro Gly Ala Glu Val Pro Glu Gly Glu Cys Cys Pro Val Cys Pro 
                85                  90                  95      


Asp Gly Ser Glu Ser Pro Thr Asp Gln Glu Thr Thr Gly Val Glu Gly 
            100                 105                 110         


Pro Lys Gly Asp Thr Gly Pro Arg Gly Pro Arg Gly Pro Ala Gly Pro 
        115                 120                 125             


Pro Gly Arg Asp Gly Ile Pro Gly Gln Pro Gly Leu Pro Gly Pro Pro 
    130                 135                 140                 


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala 
145                 150                 155                 160 


Pro Gln Leu Ser Tyr Gly Tyr Asp Glu Lys Ser Thr Gly Gly Ile Ser 
                165                 170                 175     


Val Pro Gly Pro Met Gly Pro Ser Gly Pro Arg Gly Leu Pro Gly Pro 
            180                 185                 190         


Pro Gly Ala Pro Gly Pro Gln Gly Phe Gln Gly Pro Pro Gly Glu Pro 
        195                 200                 205             


Gly Glu Pro Gly Ala Ser Gly Pro Met Gly Pro Arg Gly Pro Pro Gly 
    210                 215                 220                 


Pro Pro Gly Lys Asn Gly Asp Asp Gly Glu Ala Gly Lys Pro Gly Arg 
225                 230                 235                 240 


Pro Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly Ala Arg Gly Leu Pro 
                245                 250                 255     


Gly Thr Ala Gly Leu Pro Gly Met Lys Gly His Arg Gly Phe Ser Gly 
            260                 265                 270         


Leu Asp Gly Ala Lys Gly Asp Ala Gly Pro Ala Gly Pro Lys Gly Glu 
        275                 280                 285             


Pro Gly Ser Pro Gly Glu Asn Gly Ala Pro Gly Gln Met Gly Pro Arg 
    290                 295                 300                 


Gly Leu Pro Gly Glu Arg Gly Arg Pro Gly Ala Pro Gly Pro Ala Gly 
305                 310                 315                 320 


Ala Arg Gly Asn Asp Gly Ala Thr Gly Ala Ala Gly Pro Pro Gly Pro 
                325                 330                 335     


Thr Gly Pro Ala Gly Pro Pro Gly Phe Pro Gly Ala Val Gly Ala Lys 
            340                 345                 350         


Gly Glu Ala Gly Pro Gln Gly Pro Arg Gly Ser Glu Gly Pro Gln Gly 
        355                 360                 365             


Val Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala Ala Gly Pro 
    370                 375                 380                 


Ala Gly Asn Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Ala Asn 
385                 390                 395                 400 


Gly Ala Pro Gly Ile Ala Gly Ala Pro Gly Phe Pro Gly Ala Arg Gly 
                405                 410                 415     


Pro Ser Gly Pro Gln Gly Pro Gly Gly Pro Pro Gly Pro Lys Gly Asn 
            420                 425                 430         


Ser Gly Glu Pro Gly Ala Pro Gly Ser Lys Gly Asp Thr Gly Ala Lys 
        435                 440                 445             


Gly Glu Pro Gly Pro Val Gly Val Gln Gly Pro Pro Gly Pro Ala Gly 
    450                 455                 460                 


Glu Glu Gly Lys Arg Gly Ala Arg Gly Glu Pro Gly Pro Thr Gly Leu 
465                 470                 475                 480 


Pro Gly Pro Pro Gly Glu Arg Gly Gly Pro Gly Ser Arg Gly Phe Pro 
                485                 490                 495     


Gly Ala Asp Gly Val Ala Gly Pro Lys Gly Pro Ala Gly Glu Arg Gly 
            500                 505                 510         


Ser Pro Gly Pro Ala Gly Pro Lys Gly Ser Pro Gly Glu Ala Gly Arg 
        515                 520                 525             


Pro Gly Glu Ala Gly Leu Pro Gly Ala Lys Gly Leu Thr Gly Ser Pro 
    530                 535                 540                 


Gly Ser Pro Gly Pro Asp Gly Lys Thr Gly Pro Pro Gly Pro Ala Gly 
545                 550                 555                 560 


Gln Asp Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Ala Arg Gly Gln 
                565                 570                 575     


Ala Gly Val Met Gly Phe Pro Gly Pro Lys Gly Ala Ala Gly Glu Pro 
            580                 585                 590         


Gly Lys Ala Gly Glu Arg Gly Val Pro Gly Pro Pro Gly Ala Val Gly 
        595                 600                 605             


Pro Ala Gly Lys Asp Gly Glu Ala Gly Ala Gln Gly Pro Pro Gly Pro 
    610                 615                 620                 


Ala Gly Pro Ala Gly Glu Arg Gly Glu Gln Gly Pro Ala Gly Ser Pro 
625                 630                 635                 640 


Gly Phe Gln Gly Leu Pro Gly Pro Ala Gly Pro Pro Gly Glu Ala Gly 
                645                 650                 655     


Lys Pro Gly Glu Gln Gly Val Pro Gly Asp Leu Gly Ala Pro Gly Pro 
            660                 665                 670         


Ser Gly Ala Arg Gly Glu Arg Gly Phe Pro Gly Glu Arg Gly Val Gln 
        675                 680                 685             


Gly Pro Pro Gly Pro Ala Gly Pro Arg Gly Ala Asn Gly Ala Pro Gly 
    690                 695                 700                 


Asn Asp Gly Ala Lys Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly Ser 
705                 710                 715                 720 


Gln Gly Ala Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Ala Ala 
                725                 730                 735     


Gly Leu Pro Gly Pro Lys Gly Asp Arg Gly Asp Ala Gly Pro Lys Gly 
            740                 745                 750         


Ala Asp Gly Ser Pro Gly Lys Asp Gly Val Arg Gly Leu Thr Gly Pro 
        755                 760                 765             


Ile Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Asp Lys Gly Glu Ser 
    770                 775                 780                 


Gly Pro Ser Gly Pro Ala Gly Pro Thr Gly Ala Arg Gly Ala Pro Gly 
785                 790                 795                 800 


Asp Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Phe Ala Gly Pro 
                805                 810                 815     


Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Glu Pro Gly Asp Ala 
            820                 825                 830         


Gly Ala Lys Gly Asp Ala Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly 
        835                 840                 845             


Pro Pro Gly Pro Ile Gly Asn Val Gly Ala Pro Gly Ala Lys Gly Ala 
    850                 855                 860                 


Arg Gly Ser Ala Gly Pro Pro Gly Ala Thr Gly Phe Pro Gly Ala Ala 
865                 870                 875                 880 


Gly Arg Val Gly Pro Pro Gly Pro Ser Gly Asn Ala Gly Pro Pro Gly 
                885                 890                 895     


Pro Pro Gly Pro Ala Gly Lys Glu Gly Gly Lys Gly Pro Arg Gly Glu 
            900                 905                 910         


Thr Gly Pro Ala Gly Arg Pro Gly Glu Val Gly Pro Pro Gly Pro Pro 
        915                 920                 925             


Gly Pro Ala Gly Glu Lys Gly Ser Pro Gly Ala Asp Gly Pro Ala Gly 
    930                 935                 940                 


Ala Pro Gly Thr Pro Gly Pro Gln Gly Ile Ala Gly Gln Arg Gly Val 
945                 950                 955                 960 


Val Gly Leu Pro Gly Gln Arg Gly Glu Arg Gly Phe Pro Gly Leu Pro 
                965                 970                 975     


Gly Pro Ser Gly Glu Pro Gly Lys Gln Gly Pro Ser Gly Ala Ser Gly 
            980                 985                 990         


Glu Arg Gly Pro Pro Gly Pro Met  Gly Pro Pro Gly Leu  Ala Gly Pro 
        995                 1000                 1005             


Pro Gly  Glu Ser Gly Arg Glu  Gly Ala Pro Gly Ala  Glu Gly Ser 
    1010                 1015                 1020             


Pro Gly  Arg Asp Gly Ser Pro  Gly Ala Lys Gly Asp  Arg Gly Glu 
    1025                 1030                 1035             


Thr Gly  Pro Ala Gly Pro Pro  Gly Ala Pro Gly Ala  Pro Gly Ala 
    1040                 1045                 1050             


Pro Gly  Pro Val Gly Pro Ala  Gly Lys Ser Gly Asp  Arg Gly Glu 
    1055                 1060                 1065             


Thr Gly  Pro Ala Gly Pro Ala  Gly Pro Val Gly Pro  Val Gly Ala 
    1070                 1075                 1080             


Arg Gly  Pro Ala Gly Pro Gln  Gly Pro Arg Gly Asp  Lys Gly Glu 
    1085                 1090                 1095             


Thr Gly  Glu Gln Gly Asp Arg  Gly Ile Lys Gly His  Arg Gly Phe 
    1100                 1105                 1110             


Ser Gly  Leu Gln Gly Pro Pro  Gly Pro Pro Gly Ser  Pro Gly Glu 
    1115                 1120                 1125             


Gln Gly  Pro Ser Gly Ala Ser  Gly Pro Ala Gly Pro  Arg Gly Pro 
    1130                 1135                 1140             


Pro Gly  Ser Ala Gly Ala Pro  Gly Lys Asp Gly Leu  Asn Gly Leu 
    1145                 1150                 1155             


Pro Gly  Pro Ile Gly Pro Pro  Gly Pro Arg Gly Arg  Thr Gly Asp 
    1160                 1165                 1170             


Ala Gly  Pro Val Gly Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Pro 
    1175                 1180                 1185             


Pro Gly  Pro Pro Ser Ala Gly  Phe Asp Phe Ser Phe  Leu Pro Gln 
    1190                 1195                 1200             


Pro Pro  Gln Glu Lys Ala His  Asp Gly Gly Arg Tyr  Tyr Arg Ala 
    1205                 1210                 1215             


Asp Asp  Ala Asn Val Val Arg  Asp Arg Asp Leu Glu  Val Asp Thr 
    1220                 1225                 1230             


Thr Leu  Lys Ser Leu Ser Gln  Gln Ile Glu Asn Ile  Arg Ser Pro 
    1235                 1240                 1245             


Glu Gly  Ser Arg Lys Asn Pro  Ala Arg Thr Cys Arg  Asp Leu Lys 
    1250                 1255                 1260             


Met Cys  His Ser Asp Trp Lys  Ser Gly Glu Tyr Trp  Ile Asp Pro 
    1265                 1270                 1275             


Asn Gln  Gly Cys Asn Leu Asp  Ala Ile Lys Val Phe  Cys Asn Met 
    1280                 1285                 1290             


Glu Thr  Gly Glu Thr Cys Val  Tyr Pro Thr Gln Pro  Ser Val Ala 
    1295                 1300                 1305             


Gln Lys  Asn Trp Tyr Ile Ser  Lys Asn Pro Lys Asp  Lys Arg His 
    1310                 1315                 1320             


Val Trp  Phe Gly Glu Ser Met  Thr Asp Gly Phe Gln  Phe Glu Tyr 
    1325                 1330                 1335             


Gly Gly  Gln Gly Ser Asp Pro  Ala Asp Val Ala Ile  Gln Leu Thr 
    1340                 1345                 1350             


Phe Leu  Arg Leu Met Ser Thr  Glu Ala Ser Gln Asn  Ile Thr Tyr 
    1355                 1360                 1365             


His Cys  Lys Asn Ser Val Ala  Tyr Met Asp Gln Gln  Thr Gly Asn 
    1370                 1375                 1380             


Leu Lys  Lys Ala Leu Leu Leu  Gln Gly Ser Asn Glu  Ile Glu Ile 
    1385                 1390                 1395             


Arg Ala  Glu Gly Asn Ser Arg  Phe Thr Tyr Ser Val  Thr Val Asp 
    1400                 1405                 1410             


Gly Cys  Thr Ser His Thr Gly  Ala Trp Gly Lys Thr  Val Ile Glu 
    1415                 1420                 1425             


Tyr Lys  Thr Thr Lys Thr Ser  Arg Leu Pro Ile Ile  Asp Val Ala 
    1430                 1435                 1440             


Pro Leu  Asp Val Gly Ala Pro  Asp Gln Glu Phe Gly  Phe Asp Val 
    1445                 1450                 1455             


Gly Pro  Val Cys Phe Leu 
    1460                 


<210>  3255
<211>  154
<212>  PRT
<213>  Homo Sapiens

<400>  3255

Met Arg Ser Arg Arg Ala Phe Lys Asp Leu Arg Lys Glu Glu Arg Gly 
1               5                   10                  15      


Glu Gly Arg Glu Val Lys Asn Pro Ser Val Pro Leu Arg Pro Gly Gly 
            20                  25                  30          


Lys Val Val Lys Leu Gly Val Ala Val Thr Thr Asp Asn Ala Pro Leu 
        35                  40                  45              


Pro Pro Val Pro Val Pro Pro Ile Thr Cys Val Gln Asn Gly Leu Arg 
    50                  55                  60                  


Tyr His Asp Arg Asp Val Trp Lys Pro Glu Pro Cys Arg Ile Cys Val 
65                  70                  75                  80  


Cys Asp Asn Gly Lys Val Leu Cys Asp Asp Val Ile Cys Asp Glu Thr 
                85                  90                  95      


Lys Asn Cys Pro Gly Ala Glu Val Pro Glu Gly Glu Cys Cys Pro Val 
            100                 105                 110         


Cys Pro Asp Gly Ser Glu Ser Pro Thr Asp Gln Glu Thr Thr Gly Val 
        115                 120                 125             


Glu Gly Pro Lys Gly Asp Thr Gly Pro Arg Gly Pro Arg Gly Pro Ala 
    130                 135                 140                 


Gly Pro Pro Gly Arg Asp Gly Ile Pro Gly 
145                 150                 


<210>  3256
<211>  1364
<212>  PRT
<213>  Homo Sapiens

<400>  3256

Met Leu Ser Phe Val Asp Thr Arg Thr Leu Leu Leu Leu Ala Val Thr 
1               5                   10                  15      


Leu Cys Leu Ala Thr Cys Gln Phe Phe Glu Thr Val Arg Lys Gly Pro 
            20                  25                  30          


Ala Gly Asp Arg Gly Pro Arg Gly Glu Arg Gly Pro Pro Gly Pro Pro 
        35                  40                  45              


Gly Arg Asp Gly Glu Asp Gly Pro Thr Gly Pro Pro Gly Pro Pro Gly 
    50                  55                  60                  


Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala Ala Gln Tyr Asp 
65                  70                  75                  80  


Gly Lys Gly Val Gly Leu Gly Pro Gly Pro Met Gly Leu Met Gly Pro 
                85                  90                  95      


Arg Gly Pro Pro Gly Ala Ala Gly Ala Pro Gly Pro Gln Gly Phe Gln 
            100                 105                 110         


Gly Pro Ala Gly Glu Pro Gly Glu Pro Gly Gln Thr Gly Pro Ala Gly 
        115                 120                 125             


Ala Arg Gly Pro Ala Gly Pro Pro Gly Lys Ala Gly Glu Asp Gly His 
    130                 135                 140                 


Pro Gly Lys Pro Gly Arg Pro Gly Glu Arg Gly Val Val Gly Pro Gln 
145                 150                 155                 160 


Gly Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Pro Gly Phe Lys Gly 
                165                 170                 175     


Ile Arg Gly His Asn Gly Leu Asp Gly Leu Lys Gly Gln Pro Gly Ala 
            180                 185                 190         


Pro Gly Val Lys Gly Glu Pro Gly Ala Pro Gly Glu Asn Gly Thr Pro 
        195                 200                 205             


Gly Gln Thr Gly Ala Arg Gly Leu Pro Gly Glu Arg Gly Arg Val Gly 
    210                 215                 220                 


Ala Pro Gly Pro Ala Gly Ala Arg Gly Ser Asp Gly Ser Val Gly Pro 
225                 230                 235                 240 


Val Gly Pro Ala Gly Pro Ile Gly Ser Ala Gly Pro Pro Gly Phe Pro 
                245                 250                 255     


Gly Ala Pro Gly Pro Lys Gly Glu Ile Gly Ala Val Gly Asn Ala Gly 
            260                 265                 270         


Pro Ala Gly Pro Ala Gly Pro Arg Gly Glu Val Gly Leu Pro Gly Leu 
        275                 280                 285             


Ser Gly Pro Val Gly Pro Pro Gly Asn Pro Gly Ala Asn Gly Leu Thr 
    290                 295                 300                 


Gly Ala Lys Gly Ala Ala Gly Leu Pro Gly Val Ala Gly Ala Pro Gly 
305                 310                 315                 320 


Leu Pro Gly Pro Arg Gly Ile Pro Gly Pro Val Gly Ala Ala Gly Ala 
                325                 330                 335     


Thr Gly Ala Arg Gly Leu Val Gly Glu Pro Gly Pro Ala Gly Ser Lys 
            340                 345                 350         


Gly Glu Ser Gly Asn Lys Gly Glu Pro Gly Ser Ala Gly Pro Gln Gly 
        355                 360                 365             


Pro Pro Gly Pro Ser Gly Glu Glu Gly Lys Arg Gly Pro Asn Gly Glu 
    370                 375                 380                 


Ala Gly Ser Ala Gly Pro Pro Gly Pro Pro Gly Leu Arg Gly Ser Pro 
385                 390                 395                 400 


Gly Ser Arg Gly Leu Pro Gly Ala Asp Gly Arg Ala Gly Val Met Gly 
                405                 410                 415     


Pro Pro Gly Ser Arg Gly Ala Ser Gly Pro Ala Gly Val Arg Gly Pro 
            420                 425                 430         


Asn Gly Asp Ala Gly Arg Pro Gly Glu Pro Gly Leu Met Gly Pro Arg 
        435                 440                 445             


Gly Leu Pro Gly Ser Pro Gly Asn Ile Gly Pro Ala Gly Lys Glu Gly 
    450                 455                 460                 


Pro Val Gly Leu Pro Gly Ile Asp Gly Arg Pro Gly Pro Ile Gly Pro 
465                 470                 475                 480 


Ala Gly Ala Arg Gly Glu Pro Gly Asn Ile Gly Phe Pro Gly Pro Lys 
                485                 490                 495     


Gly Pro Thr Gly Asp Pro Gly Lys Asn Gly Asp Lys Gly His Ala Gly 
            500                 505                 510         


Leu Ala Gly Ala Arg Gly Ala Pro Gly Pro Asp Gly Asn Asn Gly Ala 
        515                 520                 525             


Gln Gly Pro Pro Gly Pro Gln Gly Val Gln Gly Gly Lys Gly Glu Gln 
    530                 535                 540                 


Gly Pro Pro Gly Pro Pro Gly Phe Gln Gly Leu Pro Gly Pro Ser Gly 
545                 550                 555                 560 


Pro Ala Gly Glu Val Gly Lys Pro Gly Glu Arg Gly Leu His Gly Glu 
                565                 570                 575     


Phe Gly Leu Pro Gly Pro Ala Gly Pro Arg Gly Glu Arg Gly Pro Pro 
            580                 585                 590         


Gly Glu Ser Gly Ala Ala Gly Pro Thr Gly Pro Ile Gly Ser Arg Gly 
        595                 600                 605             


Pro Ser Gly Pro Pro Gly Pro Asp Gly Asn Lys Gly Glu Pro Gly Val 
    610                 615                 620                 


Val Gly Ala Val Gly Thr Ala Gly Pro Ser Gly Pro Ser Gly Leu Pro 
625                 630                 635                 640 


Gly Glu Arg Gly Ala Ala Gly Ile Pro Gly Gly Lys Gly Glu Lys Gly 
                645                 650                 655     


Glu Pro Gly Leu Arg Gly Glu Ile Gly Asn Pro Gly Arg Asp Gly Ala 
            660                 665                 670         


Arg Gly Ala Pro Gly Ala Val Gly Ala Pro Gly Pro Ala Gly Ala Thr 
        675                 680                 685             


Gly Asp Arg Gly Glu Ala Gly Ala Ala Gly Pro Ala Gly Pro Ala Gly 
    690                 695                 700                 


Pro Arg Gly Ser Pro Gly Glu Arg Gly Glu Val Gly Pro Ala Gly Pro 
705                 710                 715                 720 


Asn Gly Phe Ala Gly Pro Ala Gly Ala Ala Gly Gln Pro Gly Ala Lys 
                725                 730                 735     


Gly Glu Arg Gly Ala Lys Gly Pro Lys Gly Glu Asn Gly Val Val Gly 
            740                 745                 750         


Pro Thr Gly Pro Val Gly Ala Ala Gly Pro Ala Gly Pro Asn Gly Pro 
        755                 760                 765             


Pro Gly Pro Ala Gly Ser Arg Gly Asp Gly Gly Pro Pro Gly Met Thr 
    770                 775                 780                 


Gly Phe Pro Gly Ala Ala Gly Arg Thr Gly Pro Pro Gly Pro Ser Gly 
785                 790                 795                 800 


Ile Ser Gly Pro Pro Gly Pro Pro Gly Pro Ala Gly Lys Glu Gly Leu 
                805                 810                 815     


Arg Gly Pro Arg Gly Asp Gln Gly Pro Val Gly Arg Thr Gly Glu Val 
            820                 825                 830         


Gly Ala Val Gly Pro Pro Gly Phe Ala Gly Glu Lys Gly Pro Ser Gly 
        835                 840                 845             


Glu Ala Gly Thr Ala Gly Pro Pro Gly Thr Pro Gly Pro Gln Gly Leu 
    850                 855                 860                 


Leu Gly Ala Pro Gly Ile Leu Gly Leu Pro Gly Ser Arg Gly Glu Arg 
865                 870                 875                 880 


Gly Leu Pro Gly Val Ala Gly Ala Val Gly Glu Pro Gly Pro Leu Gly 
                885                 890                 895     


Ile Ala Gly Pro Pro Gly Ala Arg Gly Pro Pro Gly Ala Val Gly Ser 
            900                 905                 910         


Pro Gly Val Asn Gly Ala Pro Gly Glu Ala Gly Arg Asp Gly Asn Pro 
        915                 920                 925             


Gly Asn Asp Gly Pro Pro Gly Arg Asp Gly Gln Pro Gly His Lys Gly 
    930                 935                 940                 


Glu Arg Gly Tyr Pro Gly Asn Ile Gly Pro Val Gly Ala Ala Gly Ala 
945                 950                 955                 960 


Pro Gly Pro His Gly Pro Val Gly Pro Ala Gly Lys His Gly Asn Arg 
                965                 970                 975     


Gly Glu Thr Gly Pro Ser Gly Pro Val Gly Pro Ala Gly Ala Val Gly 
            980                 985                 990         


Pro Arg Gly Pro Ser Gly Pro Gln  Gly Ile Arg Gly Asp  Lys Gly Glu 
        995                 1000                 1005             


Pro Gly  Glu Lys Gly Pro Arg  Gly Leu Pro Gly Leu  Lys Gly His 
    1010                 1015                 1020             


Asn Gly  Leu Gln Gly Leu Pro  Gly Ile Ala Gly His  His Gly Asp 
    1025                 1030                 1035             


Gln Gly  Ala Pro Gly Ser Val  Gly Pro Ala Gly Pro  Arg Gly Pro 
    1040                 1045                 1050             


Ala Gly  Pro Ser Gly Pro Ala  Gly Lys Asp Gly Arg  Thr Gly His 
    1055                 1060                 1065             


Pro Gly  Thr Val Gly Pro Ala  Gly Ile Arg Gly Pro  Gln Gly His 
    1070                 1075                 1080             


Gln Gly  Pro Ala Gly Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Pro 
    1085                 1090                 1095             


Pro Gly  Val Ser Gly Gly Gly  Tyr Asp Phe Gly Tyr  Asp Gly Asp 
    1100                 1105                 1110             


Phe Tyr  Arg Ala Asp Gln Pro  Arg Ser Ala Pro Ser  Leu Arg Pro 
    1115                 1120                 1125             


Lys Asp  Tyr Glu Val Asp Ala  Thr Leu Lys Ser Leu  Asn Asn Gln 
    1130                 1135                 1140             


Ile Glu  Thr Leu Leu Thr Pro  Glu Gly Ser Arg Lys  Asn Pro Ala 
    1145                 1150                 1155             


Arg Thr  Cys Arg Asp Leu Arg  Leu Ser His Pro Glu  Trp Ser Ser 
    1160                 1165                 1170             


Gly Tyr  Tyr Trp Ile Asp Pro  Asn Gln Gly Cys Thr  Met Asp Ala 
    1175                 1180                 1185             


Ile Lys  Val Tyr Cys Asp Phe  Ser Thr Gly Glu Thr  Cys Ile Arg 
    1190                 1195                 1200             


Ala Gln  Pro Glu Asn Ile Pro  Ala Lys Asn Trp Tyr  Arg Ser Ser 
    1205                 1210                 1215             


Lys Asp  Lys Lys His Val Trp  Leu Gly Glu Thr Ile  Asn Ala Gly 
    1220                 1225                 1230             


Ser Gln  Phe Glu Tyr Asn Val  Glu Gly Val Thr Ser  Lys Glu Met 
    1235                 1240                 1245             


Ala Thr  Gln Leu Ala Phe Met  Arg Leu Leu Ala Asn  Tyr Ala Ser 
    1250                 1255                 1260             


Gln Asn  Ile Thr Tyr His Cys  Lys Asn Ser Ile Ala  Tyr Met Asp 
    1265                 1270                 1275             


Glu Glu  Thr Gly Asn Leu Lys  Lys Ala Val Ile Leu  Gln Gly Ser 
    1280                 1285                 1290             


Asn Asp  Val Glu Leu Val Ala  Glu Gly Asn Ser Arg  Phe Thr Tyr 
    1295                 1300                 1305             


Thr Val  Leu Val Asp Gly Cys  Ser Lys Lys Thr Asn  Glu Trp Gly 
    1310                 1315                 1320             


Lys Thr  Ile Ile Glu Tyr Lys  Thr Asn Lys Pro Ser  Arg Leu Pro 
    1325                 1330                 1335             


Phe Leu  Asp Ile Ala Pro Leu  Asp Ile Gly Gly Ala  Asp Gln Glu 
    1340                 1345                 1350             


Phe Phe  Val Asp Ile Gly Pro  Val Cys Phe Lys 
    1355                 1360                 


<210>  3257
<211>  1366
<212>  PRT
<213>  Homo Sapiens

<400>  3257

Met Leu Ser Phe Val Asp Thr Arg Thr Leu Leu Leu Leu Ala Val Thr 
1               5                   10                  15      


Leu Cys Leu Ala Thr Cys Gln Ser Leu Gln Glu Glu Thr Val Arg Lys 
            20                  25                  30          


Gly Pro Ala Gly Asp Arg Gly Pro Arg Gly Glu Arg Gly Pro Pro Gly 
        35                  40                  45              


Pro Pro Gly Arg Asp Gly Glu Asp Gly Pro Thr Gly Pro Pro Gly Pro 
    50                  55                  60                  


Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala Ala Gln 
65                  70                  75                  80  


Tyr Asp Gly Lys Gly Val Gly Leu Gly Pro Gly Pro Met Gly Leu Met 
                85                  90                  95      


Gly Pro Arg Gly Pro Pro Gly Ala Ala Gly Ala Pro Gly Pro Gln Gly 
            100                 105                 110         


Phe Gln Gly Pro Ala Gly Glu Pro Gly Glu Pro Gly Gln Thr Gly Pro 
        115                 120                 125             


Ala Gly Ala Arg Gly Pro Ala Gly Pro Pro Gly Lys Ala Gly Glu Asp 
    130                 135                 140                 


Gly His Pro Gly Lys Pro Gly Arg Pro Gly Glu Arg Gly Val Val Gly 
145                 150                 155                 160 


Pro Gln Gly Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Pro Gly Phe 
                165                 170                 175     


Lys Gly Ile Arg Gly His Asn Gly Leu Asp Gly Leu Lys Gly Gln Pro 
            180                 185                 190         


Gly Ala Pro Gly Val Lys Gly Glu Pro Gly Ala Pro Gly Glu Asn Gly 
        195                 200                 205             


Thr Pro Gly Gln Thr Gly Ala Arg Gly Leu Pro Gly Glu Arg Gly Arg 
    210                 215                 220                 


Val Gly Ala Pro Gly Pro Ala Gly Ala Arg Gly Ser Asp Gly Ser Val 
225                 230                 235                 240 


Gly Pro Val Gly Pro Ala Gly Pro Ile Gly Ser Ala Gly Pro Pro Gly 
                245                 250                 255     


Phe Pro Gly Ala Pro Gly Pro Lys Gly Glu Ile Gly Ala Val Gly Asn 
            260                 265                 270         


Ala Gly Pro Ala Gly Pro Ala Gly Pro Arg Gly Glu Val Gly Leu Pro 
        275                 280                 285             


Gly Leu Ser Gly Pro Val Gly Pro Pro Gly Asn Pro Gly Ala Asn Gly 
    290                 295                 300                 


Leu Thr Gly Ala Lys Gly Ala Ala Gly Leu Pro Gly Val Ala Gly Ala 
305                 310                 315                 320 


Pro Gly Leu Pro Gly Pro Arg Gly Ile Pro Gly Pro Val Gly Ala Ala 
                325                 330                 335     


Gly Ala Thr Gly Ala Arg Gly Leu Val Gly Glu Pro Gly Pro Ala Gly 
            340                 345                 350         


Ser Lys Gly Glu Ser Gly Asn Lys Gly Glu Pro Gly Ser Ala Gly Pro 
        355                 360                 365             


Gln Gly Pro Pro Gly Pro Ser Gly Glu Glu Gly Lys Arg Gly Pro Asn 
    370                 375                 380                 


Gly Glu Ala Gly Ser Ala Gly Pro Pro Gly Pro Pro Gly Leu Arg Gly 
385                 390                 395                 400 


Ser Pro Gly Ser Arg Gly Leu Pro Gly Ala Asp Gly Arg Ala Gly Val 
                405                 410                 415     


Met Gly Pro Pro Gly Ser Arg Gly Ala Ser Gly Pro Ala Gly Val Arg 
            420                 425                 430         


Gly Pro Asn Gly Asp Ala Gly Arg Pro Gly Glu Pro Gly Leu Met Gly 
        435                 440                 445             


Pro Arg Gly Leu Pro Gly Ser Pro Gly Asn Ile Gly Pro Ala Gly Lys 
    450                 455                 460                 


Glu Gly Pro Val Gly Leu Pro Gly Ile Asp Gly Arg Pro Gly Pro Ile 
465                 470                 475                 480 


Gly Pro Ala Gly Ala Arg Gly Glu Pro Gly Asn Ile Gly Phe Pro Gly 
                485                 490                 495     


Pro Lys Gly Pro Thr Gly Asp Pro Gly Lys Asn Gly Asp Lys Gly His 
            500                 505                 510         


Ala Gly Leu Ala Gly Ala Arg Gly Ala Pro Gly Pro Asp Gly Asn Asn 
        515                 520                 525             


Gly Ala Gln Gly Pro Pro Gly Pro Gln Gly Val Gln Gly Gly Lys Gly 
    530                 535                 540                 


Glu Gln Gly Pro Pro Gly Pro Pro Gly Phe Gln Gly Leu Pro Gly Pro 
545                 550                 555                 560 


Ser Gly Pro Ala Gly Glu Val Gly Lys Pro Gly Glu Arg Gly Leu His 
                565                 570                 575     


Gly Glu Phe Gly Leu Pro Gly Pro Ala Gly Pro Arg Gly Glu Arg Gly 
            580                 585                 590         


Pro Pro Gly Glu Ser Gly Ala Ala Gly Pro Thr Gly Pro Ile Gly Ser 
        595                 600                 605             


Arg Gly Pro Ser Gly Pro Pro Gly Pro Asp Gly Asn Lys Gly Glu Pro 
    610                 615                 620                 


Gly Val Val Gly Ala Val Gly Thr Ala Gly Pro Ser Gly Pro Ser Gly 
625                 630                 635                 640 


Leu Pro Gly Glu Arg Gly Ala Ala Gly Ile Pro Gly Gly Lys Gly Glu 
                645                 650                 655     


Lys Gly Glu Pro Gly Leu Arg Gly Glu Ile Gly Asn Pro Gly Arg Asp 
            660                 665                 670         


Gly Ala Arg Gly Ala Pro Gly Ala Val Gly Ala Pro Gly Pro Ala Gly 
        675                 680                 685             


Ala Thr Gly Asp Arg Gly Glu Ala Gly Ala Ala Gly Pro Ala Gly Pro 
    690                 695                 700                 


Ala Gly Pro Arg Gly Ser Pro Gly Glu Arg Gly Glu Val Gly Pro Ala 
705                 710                 715                 720 


Gly Pro Asn Gly Phe Ala Gly Pro Ala Gly Ala Ala Gly Gln Pro Gly 
                725                 730                 735     


Ala Lys Gly Glu Arg Gly Ala Lys Gly Pro Lys Gly Glu Asn Gly Val 
            740                 745                 750         


Val Gly Pro Thr Gly Pro Val Gly Ala Ala Gly Pro Ala Gly Pro Asn 
        755                 760                 765             


Gly Pro Pro Gly Pro Ala Gly Ser Arg Gly Asp Gly Gly Pro Pro Gly 
    770                 775                 780                 


Met Thr Gly Phe Pro Gly Ala Ala Gly Arg Thr Gly Pro Pro Gly Pro 
785                 790                 795                 800 


Ser Gly Ile Ser Gly Pro Pro Gly Pro Pro Gly Pro Ala Gly Lys Glu 
                805                 810                 815     


Gly Leu Arg Gly Pro Arg Gly Asp Gln Gly Pro Val Gly Arg Thr Gly 
            820                 825                 830         


Glu Val Gly Ala Val Gly Pro Pro Gly Phe Ala Gly Glu Lys Gly Pro 
        835                 840                 845             


Ser Gly Glu Ala Gly Thr Ala Gly Pro Pro Gly Thr Pro Gly Pro Gln 
    850                 855                 860                 


Gly Leu Leu Gly Ala Pro Gly Ile Leu Gly Leu Pro Gly Ser Arg Gly 
865                 870                 875                 880 


Glu Arg Gly Leu Pro Gly Val Ala Gly Ala Val Gly Glu Pro Gly Pro 
                885                 890                 895     


Leu Gly Ile Ala Gly Pro Pro Gly Ala Arg Gly Pro Pro Gly Ala Val 
            900                 905                 910         


Gly Ser Pro Gly Val Asn Gly Ala Pro Gly Glu Ala Gly Arg Asp Gly 
        915                 920                 925             


Asn Pro Gly Asn Asp Gly Pro Pro Gly Arg Asp Gly Gln Pro Gly His 
    930                 935                 940                 


Lys Gly Glu Arg Gly Tyr Pro Gly Asn Ile Gly Pro Val Gly Ala Ala 
945                 950                 955                 960 


Gly Ala Pro Gly Pro His Gly Pro Val Gly Pro Ala Gly Lys His Gly 
                965                 970                 975     


Asn Arg Gly Glu Thr Gly Pro Ser Gly Pro Val Gly Pro Ala Gly Ala 
            980                 985                 990         


Val Gly Pro Arg Gly Pro Ser Gly  Pro Gln Gly Ile Arg  Gly Asp Lys 
        995                 1000                 1005             


Gly Glu  Pro Gly Glu Lys Gly  Pro Arg Gly Leu Pro  Gly Leu Lys 
    1010                 1015                 1020             


Gly His  Asn Gly Leu Gln Gly  Leu Pro Gly Ile Ala  Gly His His 
    1025                 1030                 1035             


Gly Asp  Gln Gly Ala Pro Gly  Ser Val Gly Pro Ala  Gly Pro Arg 
    1040                 1045                 1050             


Gly Pro  Ala Gly Pro Ser Gly  Pro Ala Gly Lys Asp  Gly Arg Thr 
    1055                 1060                 1065             


Gly His  Pro Gly Thr Val Gly  Pro Ala Gly Ile Arg  Gly Pro Gln 
    1070                 1075                 1080             


Gly His  Gln Gly Pro Ala Gly  Pro Pro Gly Pro Pro  Gly Pro Pro 
    1085                 1090                 1095             


Gly Pro  Pro Gly Val Ser Gly  Gly Gly Tyr Asp Phe  Gly Tyr Asp 
    1100                 1105                 1110             


Gly Asp  Phe Tyr Arg Ala Asp  Gln Pro Arg Ser Ala  Pro Ser Leu 
    1115                 1120                 1125             


Arg Pro  Lys Asp Tyr Glu Val  Asp Ala Thr Leu Lys  Ser Leu Asn 
    1130                 1135                 1140             


Asn Gln  Ile Glu Thr Leu Leu  Thr Pro Glu Gly Ser  Arg Lys Asn 
    1145                 1150                 1155             


Pro Ala  Arg Thr Cys Arg Asp  Leu Arg Leu Ser His  Pro Glu Trp 
    1160                 1165                 1170             


Ser Ser  Gly Tyr Tyr Trp Ile  Asp Pro Asn Gln Gly  Cys Thr Met 
    1175                 1180                 1185             


Asp Ala  Ile Lys Val Tyr Cys  Asp Phe Ser Thr Gly  Glu Thr Cys 
    1190                 1195                 1200             


Ile Arg  Ala Gln Pro Glu Asn  Ile Pro Ala Lys Asn  Trp Tyr Arg 
    1205                 1210                 1215             


Ser Ser  Lys Asp Lys Lys His  Val Trp Leu Gly Glu  Thr Ile Asn 
    1220                 1225                 1230             


Ala Gly  Ser Gln Phe Glu Tyr  Asn Val Glu Gly Val  Thr Ser Lys 
    1235                 1240                 1245             


Glu Met  Ala Thr Gln Leu Ala  Phe Met Arg Leu Leu  Ala Asn Tyr 
    1250                 1255                 1260             


Ala Ser  Gln Asn Ile Thr Tyr  His Cys Lys Asn Ser  Ile Ala Tyr 
    1265                 1270                 1275             


Met Asp  Glu Glu Thr Gly Asn  Leu Lys Lys Ala Val  Ile Leu Gln 
    1280                 1285                 1290             


Gly Ser  Asn Asp Val Glu Leu  Val Ala Glu Gly Asn  Ser Arg Phe 
    1295                 1300                 1305             


Thr Tyr  Thr Val Leu Val Asp  Gly Cys Ser Lys Lys  Thr Asn Glu 
    1310                 1315                 1320             


Trp Gly  Lys Thr Ile Ile Glu  Tyr Lys Thr Asn Lys  Pro Ser Arg 
    1325                 1330                 1335             


Leu Pro  Phe Leu Asp Ile Ala  Pro Leu Asp Ile Gly  Gly Ala Asp 
    1340                 1345                 1350             


Gln Glu  Phe Phe Val Asp Ile  Gly Pro Val Cys Phe  Lys 
    1355                 1360                 1365     


<210>  3258
<211>  401
<212>  PRT
<213>  Homo Sapiens

<400>  3258

Glu His Thr Ile Val Phe Leu Val Arg Leu Leu Pro Glu Thr Pro Arg 
1               5                   10                  15      


Glu Ala Phe Ala Leu Trp Gln Met Thr Ala Glu Asp Phe Gln Pro Leu 
            20                  25                  30          


Leu Gly Val Leu Leu Asp Ala Gly Lys Lys Ser Leu Thr Tyr Phe His 
        35                  40                  45              


Arg Asp Pro Arg Ala Ala Leu Gln Glu Ala Thr Phe Asp Pro Gln Glu 
    50                  55                  60                  


Val Arg Lys Ile Phe Phe Gly Ser Phe His Lys Val His Val Ala Val 
65                  70                  75                  80  


Gly Arg Ser Lys Val Arg Leu Tyr Val Asp Cys Arg Lys Val Ala Glu 
                85                  90                  95      


Arg Pro Leu Gly Glu Met Gly Ser Pro Pro Ala Ala Gly Phe Val Thr 
            100                 105                 110         


Leu Gly Arg Leu Ala Lys Ala Arg Gly Pro Arg Ser Ser Ser Ala Ala 
        115                 120                 125             


Phe Gln Leu Gln Met Leu Gln Ile Val Cys Ser Asp Thr Trp Ala Asp 
    130                 135                 140                 


Glu Asp Arg Cys Cys Glu Leu Pro Ala Ser Arg Asp Gly Glu Thr Cys 
145                 150                 155                 160 


Pro Ala Phe Val Ser Ala Cys Ser Cys Ser Ser Glu Thr Pro Gly Pro 
                165                 170                 175     


Pro Gly Pro Gln Gly Pro Pro Gly Leu Pro Gly Arg Asn Gly Thr Pro 
            180                 185                 190         


Gly Glu Gln Gly Phe Pro Gly Pro Arg Gly Glu Pro Gly Pro Pro Gly 
        195                 200                 205             


Gln Met Gly Pro Glu Gly Pro Gly Gly Gln Gln Gly Ser Pro Gly Thr 
    210                 215                 220                 


Gln Gly Arg Ala Val Gln Gly Pro Val Gly Pro Pro Gly Val Lys Gly 
225                 230                 235                 240 


Glu Lys Gly Asp His Gly Leu Pro Gly Leu Gln Gly His Pro Gly His 
                245                 250                 255     


Gln Gly Ile Pro Gly Arg Val Gly Leu Gln Gly Pro Lys Gly Met Arg 
            260                 265                 270         


Gly Leu Glu Gly Thr Ala Gly Leu Pro Gly Pro Pro Gly Pro Arg Gly 
        275                 280                 285             


Phe Gln Gly Met Ala Gly Ala Arg Gly Thr Ser Gly Glu Arg Gly Pro 
    290                 295                 300                 


Pro Gly Thr Val Gly Pro Thr Gly Leu Pro Gly Pro Lys Gly Glu Arg 
305                 310                 315                 320 


Gly Glu Lys Gly Glu Pro Gln Ser Leu Ala Thr Leu Tyr Gln Leu Val 
                325                 330                 335     


Ser Gln Ala Cys Glu Ser Ala Ile Gln Thr His Val Ser Lys Phe Asp 
            340                 345                 350         


Ser Phe His Glu Asn Thr Arg Pro Pro Met Pro Ile Leu Glu Gln Lys 
        355                 360                 365             


Leu Glu Pro Gly Thr Glu Pro Leu Gly Ser Pro Gly Thr Arg Ser Lys 
    370                 375                 380                 


Ala Leu Val Pro Gly Glu Trp Gly Arg Gly Gly Arg His Leu Glu Gly 
385                 390                 395                 400 


Arg 
    


<210>  3259
<211>  250
<212>  PRT
<213>  Homo Sapiens

<400>  3259

Glu Arg Pro Leu Gly Glu Met Gly Ser Pro Pro Ala Ala Gly Phe Val 
1               5                   10                  15      


Thr Leu Gly Arg Leu Ala Lys Ala Arg Gly Pro Arg Ser Ser Ser Ala 
            20                  25                  30          


Ala Phe Gln Leu Gln Met Leu Gln Ile Val Cys Ser Asp Thr Trp Ala 
        35                  40                  45              


Asp Glu Asp Arg Cys Cys Glu Leu Pro Ala Ser Arg Asp Gly Glu Thr 
    50                  55                  60                  


Cys Pro Ala Phe Val Ser Ala Cys Ser Cys Ser Ser Glu Thr Pro Gly 
65                  70                  75                  80  


Pro Pro Gly Pro Gln Gly Pro Pro Gly Pro Pro Gly Val Lys Gly Glu 
                85                  90                  95      


Lys Gly Asp His Gly Leu Pro Gly Leu Gln Gly His Pro Gly His Gln 
            100                 105                 110         


Gly Ile Pro Gly Arg Val Gly Leu Gln Gly Pro Lys Gly Met Arg Gly 
        115                 120                 125             


Leu Glu Gly Thr Ala Gly Leu Pro Gly Pro Pro Gly Pro Arg Gly Phe 
    130                 135                 140                 


Gln Gly Met Ala Gly Ala Arg Gly Thr Ser Gly Glu Arg Gly Pro Pro 
145                 150                 155                 160 


Gly Thr Val Gly Pro Thr Gly Leu Pro Gly Pro Lys Gly Glu Arg Gly 
                165                 170                 175     


Glu Lys Gly Glu Pro Gln Ser Leu Ala Thr Leu Tyr Gln Leu Val Ser 
            180                 185                 190         


Gln Ala Cys Glu Ser Ala Ile Gln Thr His Val Ser Lys Phe Asp Ser 
        195                 200                 205             


Phe His Glu Asn Thr Arg Pro Pro Met Pro Ile Leu Glu Gln Lys Leu 
    210                 215                 220                 


Glu Pro Gly Thr Glu Pro Leu Gly Ser Pro Gly Thr Arg Ser Lys Ala 
225                 230                 235                 240 


Leu Val Pro Gly Glu Trp Gly Arg Gly Gly 
                245                 250 


<210>  3260
<211>  1284
<212>  PRT
<213>  Homo Sapiens

<400>  3260

Met Ser Ser Gly Asp Pro Ala His Leu Gly Leu Cys Leu Trp Leu Trp 
1               5                   10                  15      


Leu Gly Ala Thr Leu Gly Arg Glu Gln Val Gln Ala Ser Gly Leu Leu 
            20                  25                  30          


Arg Leu Ala Val Leu Pro Glu Asp Arg Leu Gln Met Lys Trp Arg Glu 
        35                  40                  45              


Ser Glu Gly Ser Gly Leu Gly Tyr Leu Val Gln Val Lys Pro Met Ala 
    50                  55                  60                  


Gly Asp Ser Glu Gln Glu Val Ile Leu Thr Thr Lys Thr Pro Lys Ala 
65                  70                  75                  80  


Thr Val Gly Gly Leu Ser Pro Ser Lys Gly Tyr Thr Leu Gln Ile Phe 
                85                  90                  95      


Glu Leu Thr Gly Ser Gly Arg Phe Leu Leu Ala Arg Arg Glu Phe Val 
            100                 105                 110         


Ile Glu Asp Leu Lys Ser Ser Ser Leu Asp Arg Ser Ser Gln Arg Pro 
        115                 120                 125             


Leu Gly Ser Gly Ala Pro Glu Pro Thr Pro Ser His Thr Gly Ser Pro 
    130                 135                 140                 


Asp Pro Glu Gln Ala Ser Glu Pro Gln Val Ala Phe Thr Pro Ser Gln 
145                 150                 155                 160 


Asp Pro Arg Thr Pro Ala Gly Pro Gln Phe Arg Cys Leu Pro Pro Val 
                165                 170                 175     


Pro Ala Asp Met Val Phe Leu Val Asp Gly Ser Trp Ser Ile Gly His 
            180                 185                 190         


Ser His Phe Gln Gln Val Lys Asp Phe Leu Ala Ser Val Ile Ala Pro 
        195                 200                 205             


Phe Glu Ile Gly Pro Asp Lys Val Gln Val Gly Leu Thr Gln Tyr Ser 
    210                 215                 220                 


Gly Asp Ala Gln Thr Glu Trp Asp Leu Asn Ser Leu Ser Thr Lys Glu 
225                 230                 235                 240 


Gln Val Leu Ala Ala Val Arg Arg Leu Arg Tyr Lys Gly Gly Asn Thr 
                245                 250                 255     


Phe Thr Gly Leu Ala Leu Thr His Val Leu Gly Gln Asn Leu Gln Pro 
            260                 265                 270         


Ala Ala Gly Leu Arg Pro Glu Ala Ala Lys Val Val Ile Leu Val Thr 
        275                 280                 285             


Asp Gly Lys Ser Gln Asp Asp Val His Thr Ala Ala Arg Val Leu Lys 
    290                 295                 300                 


Asp Leu Gly Val Asn Val Phe Ala Val Gly Val Lys Asn Ala Asp Glu 
305                 310                 315                 320 


Ala Glu Leu Arg Leu Leu Ala Ser Pro Pro Arg Asp Ile Thr Val His 
                325                 330                 335     


Ser Val Leu Asp Phe Leu Gln Leu Gly Ala Leu Ala Gly Leu Leu Ser 
            340                 345                 350         


Arg Leu Ile Cys Gln Arg Leu Gln Gly Gly Ser Pro Arg Gln Gly Pro 
        355                 360                 365             


Ala Ala Ala Pro Ala Leu Asp Thr Leu Pro Ala Pro Thr Ser Leu Val 
    370                 375                 380                 


Leu Ser Gln Val Thr Ser Ser Ser Ile Arg Leu Ser Trp Thr Pro Ala 
385                 390                 395                 400 


Pro Arg His Pro Leu Lys Tyr Leu Ile Val Trp Arg Ala Ser Arg Gly 
                405                 410                 415     


Gly Thr Pro Arg Glu Val Val Val Glu Gly Pro Ala Ala Ser Thr Glu 
            420                 425                 430         


Leu His Asn Leu Ala Ser Arg Thr Glu Tyr Leu Val Ser Val Phe Pro 
        435                 440                 445             


Ile Tyr Glu Gly Gly Val Gly Glu Gly Leu Arg Gly Leu Val Thr Thr 
    450                 455                 460                 


Ala Pro Leu Pro Pro Pro Arg Ala Leu Thr Leu Ala Ala Val Thr Pro 
465                 470                 475                 480 


Arg Thr Val His Leu Thr Trp Gln Pro Ser Ala Gly Ala Thr His Tyr 
                485                 490                 495     


Leu Val Arg Cys Ser Pro Ala Ser Pro Lys Gly Glu Glu Glu Glu Arg 
            500                 505                 510         


Glu Val Gln Val Gly Arg Pro Glu Val Leu Leu Asp Gly Leu Glu Pro 
        515                 520                 525             


Gly Arg Asp Tyr Glu Val Ser Val Gln Ser Leu Arg Gly Pro Glu Gly 
    530                 535                 540                 


Ser Glu Ala Arg Gly Ile Arg Ala Arg Thr Pro Thr Leu Ala Pro Pro 
545                 550                 555                 560 


Arg His Leu Gly Phe Ser Asp Val Ser His Asp Ala Ala Arg Val Phe 
                565                 570                 575     


Trp Glu Gly Ala Pro Arg Pro Val Arg Leu Val Arg Val Thr Tyr Val 
            580                 585                 590         


Ser Ser Glu Gly Gly His Ser Gly Gln Thr Glu Ala Pro Gly Asn Ala 
        595                 600                 605             


Thr Ser Ala Thr Leu Gly Pro Leu Ser Ser Ser Thr Thr Tyr Thr Val 
    610                 615                 620                 


Arg Val Thr Cys Leu Tyr Pro Gly Gly Gly Ser Ser Thr Leu Thr Gly 
625                 630                 635                 640 


Arg Val Thr Thr Lys Lys Ala Pro Ser Pro Ser Gln Leu Ser Met Thr 
                645                 650                 655     


Glu Leu Pro Gly Asp Ala Val Gln Leu Ala Trp Val Ala Ala Ala Pro 
            660                 665                 670         


Ser Gly Val Leu Val Tyr Gln Ile Thr Trp Thr Pro Leu Gly Glu Gly 
        675                 680                 685             


Lys Ala His Glu Ile Ser Val Pro Gly Asn Leu Gly Thr Ala Val Leu 
    690                 695                 700                 


Pro Gly Leu Gly Arg His Thr Glu Tyr Asp Val Thr Ile Leu Ala Tyr 
705                 710                 715                 720 


Tyr Arg Asp Gly Ala Arg Ser Asp Pro Val Ser Leu Arg Tyr Thr Pro 
                725                 730                 735     


Ser Thr Val Ser Arg Ser Pro Pro Ser Asn Leu Ala Leu Ala Ser Glu 
            740                 745                 750         


Thr Pro Asp Ser Leu Gln Val Ser Trp Thr Pro Pro Leu Gly Arg Val 
        755                 760                 765             


Leu His Tyr Trp Leu Thr Tyr Ala Pro Ala Ser Gly Leu Gly Pro Glu 
    770                 775                 780                 


Lys Ser Val Ser Val Pro Gly Ala Arg Ser His Val Thr Leu Pro Asp 
785                 790                 795                 800 


Leu Gln Ala Ala Thr Lys Tyr Arg Val Leu Val Ser Ala Ile Tyr Ala 
                805                 810                 815     


Ala Gly Arg Ser Glu Ala Val Ser Ala Thr Gly Gln Thr Ala Cys Pro 
            820                 825                 830         


Ala Leu Arg Pro Asp Gly Ser Leu Pro Gly Phe Asp Leu Met Val Ala 
        835                 840                 845             


Phe Ser Leu Val Glu Lys Ala Tyr Ala Ser Ile Arg Gly Val Ala Met 
    850                 855                 860                 


Glu Pro Ser Ala Phe Gly Gly Thr Pro Thr Phe Thr Leu Phe Lys Asp 
865                 870                 875                 880 


Ala Gln Leu Thr Arg Arg Val Ser Asp Val Tyr Pro Ala Pro Leu Pro 
                885                 890                 895     


Pro Glu His Thr Ile Val Phe Leu Val Arg Leu Leu Pro Glu Thr Pro 
            900                 905                 910         


Arg Glu Ala Phe Ala Leu Trp Gln Met Thr Ala Glu Asp Phe Gln Pro 
        915                 920                 925             


Leu Leu Gly Val Leu Leu Asp Ala Gly Lys Lys Ser Leu Thr Tyr Phe 
    930                 935                 940                 


His Arg Asp Pro Arg Ala Ala Leu Gln Glu Ala Thr Phe Asp Pro Gln 
945                 950                 955                 960 


Glu Val Arg Lys Ile Phe Phe Gly Ser Phe His Lys Val His Val Ala 
                965                 970                 975     


Val Gly Arg Ser Lys Val Arg Leu Tyr Val Asp Cys Arg Lys Val Ala 
            980                 985                 990         


Glu Arg Pro Leu Gly Glu Met Gly  Ser Pro Pro Ala Ala  Gly Phe Val 
        995                 1000                 1005             


Thr Leu  Gly Arg Leu Ala Lys  Ala Arg Gly Pro Arg  Ser Ser Ser 
    1010                 1015                 1020             


Ala Ala  Phe Gln Leu Gln Met  Leu Gln Ile Val Cys  Ser Asp Thr 
    1025                 1030                 1035             


Trp Ala  Asp Glu Asp Arg Cys  Cys Glu Leu Pro Ala  Ser Arg Asp 
    1040                 1045                 1050             


Gly Glu  Thr Cys Pro Ala Phe  Val Ser Ala Cys Ser  Cys Ser Ser 
    1055                 1060                 1065             


Glu Thr  Pro Gly Pro Pro Gly  Pro Gln Gly Pro Pro  Gly Leu Pro 
    1070                 1075                 1080             


Gly Arg  Asn Gly Thr Pro Gly  Glu Gln Gly Phe Pro  Gly Pro Arg 
    1085                 1090                 1095             


Gly Pro  Pro Gly Val Lys Gly  Glu Lys Gly Asp His  Gly Leu Pro 
    1100                 1105                 1110             


Gly Leu  Gln Gly His Pro Gly  His Gln Gly Ile Pro  Gly Arg Val 
    1115                 1120                 1125             


Gly Leu  Gln Gly Pro Lys Gly  Met Arg Gly Leu Glu  Gly Thr Ala 
    1130                 1135                 1140             


Gly Leu  Pro Gly Pro Pro Gly  Pro Arg Gly Phe Gln  Gly Met Ala 
    1145                 1150                 1155             


Gly Ala  Arg Gly Thr Ser Gly  Glu Arg Gly Pro Pro  Gly Thr Val 
    1160                 1165                 1170             


Gly Pro  Thr Gly Leu Pro Gly  Pro Lys Gly Glu Arg  Gly Glu Lys 
    1175                 1180                 1185             


Gly Glu  Pro Gln Ser Leu Ala  Thr Leu Tyr Gln Leu  Val Ser Gln 
    1190                 1195                 1200             


Ala Ser  His Val Ser Lys Phe  Asp Ser Phe His Glu  Asn Thr Arg 
    1205                 1210                 1215             


Pro Pro  Met Pro Ile Leu Glu  Gln Lys Leu Glu Pro  Gly Thr Glu 
    1220                 1225                 1230             


Pro Leu  Gly Ser Pro Gly Thr  Arg Ser Lys Ala Leu  Val Pro Gly 
    1235                 1240                 1245             


Glu Trp  Gly Arg Gly Gly Arg  His Leu Glu Gly Arg  Gly Glu Pro 
    1250                 1255                 1260             


Gly Ala  Val Gly Gln Met Gly  Ser Pro Gly Gln Gln  Gly Ala Ser 
    1265                 1270                 1275             


Thr Gln  Gly Leu Trp Glu 
    1280                 


<210>  3261
<211>  1297
<212>  PRT
<213>  Homo Sapiens

<400>  3261

Met Ser Ser Gly Asp Pro Ala His Leu Gly Leu Cys Leu Trp Leu Trp 
1               5                   10                  15      


Leu Gly Ala Thr Leu Gly Arg Glu Gln Val Gln Ala Ser Gly Leu Leu 
            20                  25                  30          


Arg Leu Ala Val Leu Pro Glu Asp Arg Leu Gln Met Lys Trp Arg Glu 
        35                  40                  45              


Ser Glu Gly Ser Gly Leu Gly Tyr Leu Val Gln Val Lys Pro Met Ala 
    50                  55                  60                  


Gly Asp Ser Glu Gln Glu Val Ile Leu Thr Thr Lys Thr Pro Lys Ala 
65                  70                  75                  80  


Thr Val Gly Gly Leu Ser Pro Ser Lys Gly Tyr Thr Leu Gln Ile Phe 
                85                  90                  95      


Glu Leu Thr Gly Ser Gly Arg Phe Leu Leu Ala Arg Arg Glu Phe Val 
            100                 105                 110         


Ile Glu Asp Leu Lys Ser Ser Ser Leu Asp Arg Ser Ser Gln Arg Pro 
        115                 120                 125             


Leu Gly Ser Gly Ala Pro Glu Pro Thr Pro Ser His Thr Gly Ser Pro 
    130                 135                 140                 


Asp Pro Glu Gln Ala Ser Glu Pro Gln Val Ala Phe Thr Pro Ser Gln 
145                 150                 155                 160 


Asp Pro Arg Thr Pro Gly Gly Ser Glu Trp Arg Glu Thr Gly Pro Gln 
                165                 170                 175     


Phe Arg Cys Leu Pro Pro Val Pro Ala Asp Met Val Phe Leu Val Asp 
            180                 185                 190         


Gly Ser Trp Ser Ile Gly His Ser His Phe Gln Gln Val Lys Asp Phe 
        195                 200                 205             


Leu Ala Ser Val Ile Ala Pro Phe Glu Ile Gly Pro Asp Lys Val Gln 
    210                 215                 220                 


Val Gly Leu Thr Gln Tyr Ser Gly Asp Ala Gln Thr Glu Trp Asp Leu 
225                 230                 235                 240 


Asn Ser Leu Ser Thr Lys Glu Gln Val Leu Ala Ala Val Arg Arg Leu 
                245                 250                 255     


Arg Tyr Lys Gly Gly Asn Thr Phe Thr Gly Leu Ala Leu Thr His Val 
            260                 265                 270         


Leu Gly Gln Asn Leu Gln Pro Ala Ala Gly Leu Arg Pro Glu Ala Ala 
        275                 280                 285             


Lys Val Val Ile Leu Val Thr Asp Gly Lys Ser Gln Asp Asp Val His 
    290                 295                 300                 


Thr Ala Ala Arg Val Leu Lys Asp Leu Gly Val Asn Val Phe Ala Val 
305                 310                 315                 320 


Gly Val Lys Asn Ala Asp Glu Ala Glu Leu Arg Leu Leu Ala Ser Pro 
                325                 330                 335     


Pro Arg Asp Ile Thr Val His Ser Val Leu Asp Phe Leu Gln Leu Gly 
            340                 345                 350         


Ala Leu Ala Gly Leu Leu Ser Arg Leu Ile Cys Gln Arg Leu Gln Gly 
        355                 360                 365             


Gly Ser Pro Arg Gln Gly Pro Ala Ala Ala Pro Ala Leu Asp Thr Leu 
    370                 375                 380                 


Pro Ala Pro Thr Ser Leu Val Leu Ser Gln Val Thr Ser Ser Ser Ile 
385                 390                 395                 400 


Arg Leu Ser Trp Thr Pro Ala Pro Arg His Pro Leu Lys Tyr Leu Ile 
                405                 410                 415     


Val Trp Arg Ala Ser Arg Gly Gly Thr Pro Arg Glu Val Val Val Glu 
            420                 425                 430         


Gly Pro Ala Ala Ser Thr Glu Leu His Asn Leu Ala Ser Arg Thr Glu 
        435                 440                 445             


Tyr Leu Val Ser Val Phe Pro Ile Tyr Glu Gly Gly Val Gly Glu Gly 
    450                 455                 460                 


Leu Arg Gly Leu Val Thr Thr Ala Pro Leu Pro Pro Pro Arg Ala Leu 
465                 470                 475                 480 


Thr Leu Ala Ala Val Thr Pro Arg Thr Val His Leu Thr Trp Gln Pro 
                485                 490                 495     


Ser Ala Gly Ala Thr His Tyr Leu Val Arg Cys Ser Pro Ala Ser Pro 
            500                 505                 510         


Lys Gly Glu Glu Glu Glu Arg Glu Val Gln Val Gly Arg Pro Glu Val 
        515                 520                 525             


Leu Leu Asp Gly Leu Glu Pro Gly Arg Asp Tyr Glu Val Ser Val Gln 
    530                 535                 540                 


Ser Leu Arg Gly Pro Glu Gly Ser Glu Ala Arg Gly Ile Arg Ala Arg 
545                 550                 555                 560 


Thr Pro Thr Leu Ala Pro Pro Arg His Leu Gly Phe Ser Asp Val Ser 
                565                 570                 575     


His Asp Ala Ala Arg Val Phe Trp Glu Gly Ala Pro Arg Pro Val Arg 
            580                 585                 590         


Leu Val Arg Val Thr Tyr Val Ser Ser Glu Gly Gly His Ser Gly Gln 
        595                 600                 605             


Thr Glu Ala Pro Gly Asn Ala Thr Ser Ala Thr Leu Gly Pro Leu Ser 
    610                 615                 620                 


Ser Ser Thr Thr Tyr Thr Val Arg Val Thr Cys Leu Tyr Pro Gly Gly 
625                 630                 635                 640 


Gly Ser Ser Thr Leu Thr Gly Arg Val Thr Thr Lys Lys Ala Pro Ser 
                645                 650                 655     


Pro Ser Gln Leu Ser Met Thr Glu Leu Pro Gly Asp Ala Val Gln Leu 
            660                 665                 670         


Ala Trp Val Ala Ala Ala Pro Ser Gly Val Leu Val Tyr Gln Ile Thr 
        675                 680                 685             


Trp Thr Pro Leu Gly Glu Gly Lys Ala His Glu Ile Ser Val Pro Gly 
    690                 695                 700                 


Asn Leu Gly Thr Ala Val Leu Pro Gly Leu Gly Arg His Thr Glu Tyr 
705                 710                 715                 720 


Asp Val Thr Ile Leu Ala Tyr Tyr Arg Asp Gly Ala Arg Ser Asp Pro 
                725                 730                 735     


Val Ser Leu Arg Tyr Thr Pro Ser Thr Val Ser Arg Ser Pro Pro Ser 
            740                 745                 750         


Asn Leu Ala Leu Ala Ser Glu Thr Pro Asp Ser Leu Gln Val Ser Trp 
        755                 760                 765             


Thr Pro Pro Leu Gly Arg Val Leu His Tyr Trp Leu Thr Tyr Ala Pro 
    770                 775                 780                 


Ala Ser Gly Leu Gly Pro Glu Lys Ser Val Ser Val Pro Gly Ala Arg 
785                 790                 795                 800 


Ser His Val Thr Leu Pro Asp Leu Gln Ala Ala Thr Lys Tyr Arg Val 
                805                 810                 815     


Leu Val Ser Ala Ile Tyr Ala Ala Gly Arg Ser Glu Ala Val Ser Ala 
            820                 825                 830         


Thr Gly Gln Thr Ala Cys Pro Ala Leu Arg Pro Asp Gly Ser Leu Pro 
        835                 840                 845             


Gly Phe Asp Leu Met Val Ala Phe Ser Leu Val Glu Lys Ala Tyr Ala 
    850                 855                 860                 


Ser Ile Arg Gly Val Ala Met Glu Pro Ser Ala Phe Gly Gly Thr Pro 
865                 870                 875                 880 


Thr Phe Thr Leu Phe Lys Asp Ala Gln Leu Thr Arg Arg Val Ser Asp 
                885                 890                 895     


Val Tyr Pro Ala Pro Leu Pro Pro Glu His Thr Ile Val Phe Leu Val 
            900                 905                 910         


Arg Leu Leu Pro Glu Thr Pro Arg Glu Ala Phe Ala Leu Trp Gln Met 
        915                 920                 925             


Thr Ala Glu Asp Phe Gln Pro Leu Leu Gly Val Leu Leu Asp Ala Gly 
    930                 935                 940                 


Lys Lys Ser Leu Thr Tyr Phe His Arg Asp Pro Arg Ala Ala Leu Gln 
945                 950                 955                 960 


Glu Ala Thr Phe Asp Pro Gln Glu Val Arg Lys Ile Phe Phe Gly Ser 
                965                 970                 975     


Phe His Lys Val His Val Ala Val Gly Arg Ser Lys Val Arg Leu Tyr 
            980                 985                 990         


Val Asp Cys Arg Lys Val Ala Glu  Arg Pro Leu Gly Glu  Met Gly Ser 
        995                 1000                 1005             


Pro Pro  Ala Ala Gly Phe Val  Thr Leu Gly Arg Leu  Ala Lys Ala 
    1010                 1015                 1020             


Arg Gly  Pro Arg Ser Ser Ser  Ala Ala Phe Gln Leu  Gln Met Leu 
    1025                 1030                 1035             


Gln Ile  Val Cys Ser Asp Thr  Trp Ala Asp Glu Asp  Arg Cys Cys 
    1040                 1045                 1050             


Glu Leu  Pro Ala Ser Arg Asp  Gly Glu Thr Cys Pro  Ala Phe Val 
    1055                 1060                 1065             


Ser Ala  Cys Ser Cys Ser Ser  Glu Thr Pro Gly Pro  Pro Gly Pro 
    1070                 1075                 1080             


Gln Gly  Pro Pro Gly Leu Pro  Gly Arg Asn Gly Thr  Pro Gly Glu 
    1085                 1090                 1095             


Gln Gly  Phe Pro Gly Pro Arg  Gly Pro Pro Gly Val  Lys Gly Glu 
    1100                 1105                 1110             


Lys Gly  Asp His Gly Leu Pro  Gly Leu Gln Gly His  Pro Gly His 
    1115                 1120                 1125             


Gln Gly  Ile Pro Gly Arg Val  Gly Leu Gln Gly Pro  Lys Gly Met 
    1130                 1135                 1140             


Arg Gly  Leu Glu Gly Thr Ala  Gly Leu Pro Gly Pro  Pro Gly Pro 
    1145                 1150                 1155             


Arg Gly  Phe Gln Gly Met Ala  Gly Ala Arg Gly Thr  Ser Gly Glu 
    1160                 1165                 1170             


Arg Gly  Pro Pro Gly Thr Val  Gly Pro Thr Gly Leu  Pro Gly Pro 
    1175                 1180                 1185             


Lys Gly  Glu Arg Gly Glu Lys  Gly Glu Pro Gln Ser  Leu Ala Thr 
    1190                 1195                 1200             


Leu Tyr  Gln Leu Val Ser Gln  Ala Cys Glu Ser Ala  Ile Gln Thr 
    1205                 1210                 1215             


His Val  Ser Lys Phe Asp Ser  Phe His Glu Asn Thr  Arg Pro Pro 
    1220                 1225                 1230             


Met Pro  Ile Leu Glu Gln Lys  Leu Glu Pro Gly Thr  Glu Pro Leu 
    1235                 1240                 1245             


Gly Ser  Pro Gly Thr Arg Ser  Lys Ala Leu Val Pro  Gly Glu Trp 
    1250                 1255                 1260             


Gly Arg  Gly Gly Arg His Leu  Glu Gly Arg Gly Glu  Pro Gly Ala 
    1265                 1270                 1275             


Val Gly  Gln Met Gly Ser Pro  Gly Gln Gln Gly Ala  Ser Thr Gln 
    1280                 1285                 1290             


Gly Leu  Trp Glu 
    1295         


<210>  3262
<211>  79
<212>  PRT
<213>  Homo Sapiens

<400>  3262

Ala Lys Gly Asp Lys Gly Ser Pro Gly Phe Tyr Gly Lys Lys Gly Ala 
1               5                   10                  15      


Lys Gly Glu Lys Gly Asn Ala Gly Phe Pro Gly Leu Pro Gly Pro Ala 
            20                  25                  30          


Gly Glu Pro Gly Arg His Gly Lys Asp Gly Leu Met Gly Ser Pro Gly 
        35                  40                  45              


Phe Lys Gly Glu Ala Gly Ser Pro Gly Ala Pro Gly Gln Asp Gly Thr 
    50                  55                  60                  


Arg Gly Glu Pro Thr Cys Ala Tyr Glu Phe Ser His Val Lys Glu 
65                  70                  75                  


<210>  3263
<211>  136
<212>  PRT
<213>  Homo Sapiens

<400>  3263

Met Ala His Tyr Ile Thr Phe Leu Cys Met Val Leu Val Leu Leu Leu 
1               5                   10                  15      


Gln Asn Ser Val Leu Ala Glu Asp Gly Glu Val Arg Ser Ser Cys Arg 
            20                  25                  30          


Thr Ala Pro Thr Asp Leu Val Phe Ile Leu Asp Gly Ser Tyr Ser Val 
        35                  40                  45              


Gly Pro Glu Asn Phe Glu Ile Val Lys Lys Trp Leu Val Asn Ile Thr 
    50                  55                  60                  


Lys Asn Phe Asp Ile Gly Pro Lys Phe Ile Gln Val Gly Val Val Gln 
65                  70                  75                  80  


Tyr Ser Asp Tyr Pro Val Leu Glu Ile Pro Leu Gly Ser Tyr Asp Ser 
                85                  90                  95      


Gly Glu His Leu Thr Ala Ala Val Glu Ser Ile Leu Tyr Leu Gly Gly 
            100                 105                 110         


Asn Thr Lys Thr Gly Lys Ala Ile Gln Phe Ala Leu Asp Tyr Leu Phe 
        115                 120                 125             


Ala Lys Ser Ser Arg Phe Leu Thr 
    130                 135     


<210>  3264
<211>  957
<212>  PRT
<213>  Homo Sapiens

<400>  3264

Met Ala His Tyr Ile Thr Phe Leu Cys Met Val Leu Val Leu Leu Leu 
1               5                   10                  15      


Gln Asn Ser Val Leu Ala Glu Asp Gly Glu Val Arg Ser Ser Cys Arg 
            20                  25                  30          


Thr Ala Pro Thr Asp Leu Val Phe Ile Leu Asp Gly Ser Tyr Ser Val 
        35                  40                  45              


Gly Pro Glu Asn Phe Glu Ile Val Lys Lys Trp Leu Val Asn Ile Thr 
    50                  55                  60                  


Lys Asn Phe Asp Ile Gly Pro Lys Phe Ile Gln Val Gly Val Val Gln 
65                  70                  75                  80  


Tyr Ser Asp Tyr Pro Val Leu Glu Ile Pro Leu Gly Ser Tyr Asp Ser 
                85                  90                  95      


Gly Glu His Leu Thr Ala Ala Val Glu Ser Ile Leu Tyr Leu Gly Gly 
            100                 105                 110         


Asn Thr Lys Thr Gly Lys Ala Ile Gln Phe Ala Leu Asp Tyr Leu Phe 
        115                 120                 125             


Ala Lys Ser Ser Arg Phe Leu Thr Lys Ile Ala Val Val Leu Thr Asp 
    130                 135                 140                 


Gly Lys Ser Gln Asp Asp Val Lys Asp Ala Ala Gln Ala Ala Arg Asp 
145                 150                 155                 160 


Ser Lys Ile Thr Leu Phe Ala Ile Gly Val Gly Ser Glu Thr Glu Asp 
                165                 170                 175     


Ala Glu Leu Arg Ala Ile Ala Asn Lys Pro Ser Ser Thr Tyr Val Phe 
            180                 185                 190         


Tyr Val Glu Asp Tyr Ile Ala Ile Ser Lys Ile Arg Glu Val Met Lys 
        195                 200                 205             


Gln Lys Leu Cys Glu Glu Ser Val Cys Pro Thr Arg Ile Pro Val Ala 
    210                 215                 220                 


Ala Arg Asp Glu Arg Gly Phe Asp Ile Leu Leu Gly Leu Asp Val Asn 
225                 230                 235                 240 


Lys Lys Val Lys Lys Arg Ile Gln Leu Ser Pro Lys Lys Ile Lys Gly 
                245                 250                 255     


Tyr Glu Val Thr Ser Lys Val Asp Leu Ser Glu Leu Thr Ser Asn Val 
            260                 265                 270         


Phe Pro Glu Gly Leu Pro Pro Ser Tyr Val Phe Val Ser Thr Gln Arg 
        275                 280                 285             


Phe Lys Val Lys Lys Ile Trp Asp Leu Trp Arg Ile Leu Thr Ile Asp 
    290                 295                 300                 


Gly Arg Pro Gln Ile Ala Val Thr Leu Asn Gly Val Asp Lys Ile Leu 
305                 310                 315                 320 


Leu Phe Thr Thr Thr Ser Val Ile Asn Gly Ser Gln Val Val Thr Phe 
                325                 330                 335     


Ala Asn Pro Gln Val Lys Thr Leu Phe Asp Glu Gly Trp His Gln Ile 
            340                 345                 350         


Arg Leu Leu Val Thr Glu Gln Asp Val Thr Leu Tyr Ile Asp Asp Gln 
        355                 360                 365             


Gln Ile Glu Asn Lys Pro Leu His Pro Val Leu Gly Ile Leu Ile Asn 
    370                 375                 380                 


Gly Gln Thr Gln Ile Gly Lys Tyr Ser Gly Lys Glu Glu Thr Val Gln 
385                 390                 395                 400 


Phe Asp Val Gln Lys Leu Arg Ile Tyr Cys Asp Pro Glu Gln Asn Asn 
                405                 410                 415     


Arg Glu Thr Ala Cys Glu Ile Pro Gly Phe Asn Gly Glu Cys Leu Asn 
            420                 425                 430         


Gly Pro Ser Asp Val Gly Ser Thr Pro Ala Pro Cys Ile Cys Pro Pro 
        435                 440                 445             


Gly Lys Pro Gly Leu Gln Gly Pro Lys Gly Asp Pro Gly Leu Pro Gly 
    450                 455                 460                 


Asn Pro Gly Tyr Pro Gly Gln Pro Gly Gln Asp Gly Lys Pro Gly Tyr 
465                 470                 475                 480 


Gln Gly Ile Ala Gly Thr Pro Gly Val Pro Gly Ser Pro Gly Ile Gln 
                485                 490                 495     


Gly Ala Arg Gly Leu Pro Gly Tyr Lys Gly Glu Pro Gly Arg Asp Gly 
            500                 505                 510         


Asp Lys Gly Asp Arg Gly Leu Pro Gly Phe Pro Gly Leu His Gly Met 
        515                 520                 525             


Pro Gly Ser Lys Gly Glu Met Gly Ala Lys Gly Asp Lys Gly Ser Pro 
    530                 535                 540                 


Gly Phe Tyr Gly Lys Lys Gly Ala Lys Gly Glu Lys Gly Asn Ala Gly 
545                 550                 555                 560 


Phe Pro Gly Leu Pro Gly Pro Ala Gly Glu Pro Gly Arg His Gly Lys 
                565                 570                 575     


Asp Gly Leu Met Gly Ser Pro Gly Phe Lys Gly Glu Ala Gly Ser Pro 
            580                 585                 590         


Gly Ala Pro Gly Gln Asp Gly Thr Arg Gly Glu Pro Gly Ile Pro Gly 
        595                 600                 605             


Phe Pro Gly Asn Arg Gly Leu Met Gly Gln Lys Gly Glu Ile Gly Pro 
    610                 615                 620                 


Pro Gly Gln Gln Gly Lys Lys Gly Ala Pro Gly Met Pro Gly Leu Met 
625                 630                 635                 640 


Gly Ser Asn Gly Ser Pro Gly Gln Pro Gly Thr Pro Gly Ser Lys Gly 
                645                 650                 655     


Ser Lys Gly Glu Pro Gly Ile Gln Gly Met Pro Gly Ala Ser Gly Leu 
            660                 665                 670         


Lys Gly Glu Pro Gly Ala Thr Gly Ser Pro Gly Glu Pro Gly Tyr Met 
        675                 680                 685             


Gly Leu Pro Gly Ile Gln Gly Lys Lys Gly Asp Lys Gly Asn Gln Gly 
    690                 695                 700                 


Glu Lys Gly Ile Gln Gly Gln Lys Gly Glu Asn Gly Arg Gln Gly Ile 
705                 710                 715                 720 


Pro Gly Gln Gln Gly Ile Gln Gly His His Gly Ala Lys Gly Glu Arg 
                725                 730                 735     


Gly Glu Lys Gly Glu Pro Gly Val Arg Gly Ala Ile Gly Ser Lys Gly 
            740                 745                 750         


Glu Ser Gly Val Asp Gly Leu Met Gly Pro Ala Gly Pro Lys Gly Gln 
        755                 760                 765             


Pro Gly Asp Pro Gly Pro Gln Gly Pro Pro Gly Leu Asp Gly Lys Pro 
    770                 775                 780                 


Gly Arg Glu Phe Ser Glu Gln Phe Ile Arg Gln Val Cys Thr Asp Val 
785                 790                 795                 800 


Ile Arg Ala Gln Leu Pro Val Leu Leu Gln Ser Gly Arg Ile Arg Asn 
                805                 810                 815     


Cys Asp His Cys Leu Ser Gln His Gly Ser Pro Gly Ile Pro Gly Pro 
            820                 825                 830         


Pro Gly Pro Ile Gly Pro Glu Gly Pro Arg Gly Leu Pro Gly Leu Pro 
        835                 840                 845             


Gly Arg Asp Gly Val Pro Gly Leu Val Gly Val Pro Gly Arg Pro Gly 
    850                 855                 860                 


Val Arg Gly Leu Lys Gly Leu Pro Gly Arg Asn Gly Glu Lys Gly Ser 
865                 870                 875                 880 


Gln Gly Phe Gly Tyr Pro Gly Glu Gln Gly Pro Pro Gly Pro Pro Gly 
                885                 890                 895     


Pro Glu Gly Pro Pro Gly Ile Ser Lys Glu Gly Pro Pro Gly Asp Pro 
            900                 905                 910         


Gly Leu Pro Gly Lys Asp Gly Asp His Gly Lys Pro Gly Ile Gln Gly 
        915                 920                 925             


Gln Pro Gly Pro Pro Gly Ile Cys Asp Pro Ser Leu Cys Phe Ser Val 
    930                 935                 940                 


Ile Ala Arg Arg Asp Pro Phe Arg Lys Gly Pro Asn Tyr 
945                 950                 955         


<210>  3265
<211>  954
<212>  PRT
<213>  Homo Sapiens

<400>  3265

Met Ala His Tyr Ile Thr Phe Leu Cys Met Val Leu Val Leu Leu Leu 
1               5                   10                  15      


Gln Asn Ser Val Leu Ala Glu Asp Gly Glu Val Arg Ser Ser Cys Arg 
            20                  25                  30          


Thr Ala Pro Thr Asp Leu Val Phe Ile Leu Asp Gly Ser Tyr Ser Val 
        35                  40                  45              


Gly Pro Glu Asn Phe Glu Ile Val Lys Lys Trp Leu Val Asn Ile Thr 
    50                  55                  60                  


Lys Asn Phe Asp Ile Gly Pro Lys Phe Ile Gln Val Gly Val Val Gln 
65                  70                  75                  80  


Tyr Ser Asp Tyr Pro Val Leu Glu Ile Pro Leu Gly Ser Tyr Asp Ser 
                85                  90                  95      


Gly Glu His Leu Thr Ala Ala Val Glu Ser Ile Leu Tyr Leu Gly Gly 
            100                 105                 110         


Asn Thr Lys Thr Gly Lys Ala Ile Gln Phe Ala Leu Asp Tyr Leu Phe 
        115                 120                 125             


Ala Lys Ser Ser Arg Phe Leu Thr Lys Ile Ala Val Val Leu Thr Asp 
    130                 135                 140                 


Gly Lys Ser Gln Asp Asp Val Lys Asp Ala Ala Gln Ala Ala Arg Asp 
145                 150                 155                 160 


Ser Lys Ile Thr Leu Phe Ala Ile Gly Val Gly Ser Glu Thr Glu Asp 
                165                 170                 175     


Ala Glu Leu Arg Ala Ile Ala Asn Lys Pro Ser Ser Thr Tyr Val Phe 
            180                 185                 190         


Tyr Val Glu Asp Tyr Ile Ala Ile Ser Lys Ile Arg Glu Val Met Lys 
        195                 200                 205             


Gln Lys Leu Cys Glu Glu Ser Val Cys Pro Thr Arg Ile Pro Val Ala 
    210                 215                 220                 


Ala Arg Asp Glu Arg Gly Phe Asp Ile Leu Leu Gly Leu Asp Val Asn 
225                 230                 235                 240 


Lys Lys Val Lys Lys Arg Ile Gln Leu Ser Pro Lys Lys Ile Lys Gly 
                245                 250                 255     


Tyr Glu Val Thr Ser Lys Val Asp Leu Ser Glu Leu Thr Ser Asn Val 
            260                 265                 270         


Phe Pro Glu Gly Leu Pro Pro Ser Tyr Val Phe Val Ser Thr Gln Arg 
        275                 280                 285             


Phe Lys Val Lys Lys Ile Trp Asp Leu Trp Arg Ile Leu Thr Ile Asp 
    290                 295                 300                 


Gly Arg Pro Gln Ile Ala Val Thr Leu Asn Gly Val Asp Lys Ile Leu 
305                 310                 315                 320 


Leu Phe Thr Thr Thr Ser Val Ile Asn Gly Ser Gln Val Val Thr Phe 
                325                 330                 335     


Ala Asn Pro Gln Val Lys Thr Leu Phe Asp Glu Gly Trp His Gln Ile 
            340                 345                 350         


Arg Leu Leu Val Thr Glu Gln Asp Val Thr Leu Tyr Ile Asp Asp Gln 
        355                 360                 365             


Gln Ile Glu Asn Lys Pro Leu His Pro Val Leu Gly Ile Leu Ile Asn 
    370                 375                 380                 


Gly Gln Thr Gln Ile Gly Lys Tyr Ser Gly Lys Glu Glu Thr Val Gln 
385                 390                 395                 400 


Phe Asp Val Gln Lys Leu Arg Ile Tyr Cys Asp Pro Glu Gln Asn Asn 
                405                 410                 415     


Arg Glu Thr Ala Cys Glu Ile Pro Gly Phe Cys Leu Asn Gly Pro Ser 
            420                 425                 430         


Asp Val Gly Ser Thr Pro Ala Pro Cys Ile Cys Pro Pro Gly Lys Pro 
        435                 440                 445             


Gly Leu Gln Gly Pro Lys Gly Asp Pro Gly Leu Pro Gly Asn Pro Gly 
    450                 455                 460                 


Tyr Pro Gly Gln Pro Gly Gln Asp Gly Lys Pro Gly Tyr Gln Gly Ile 
465                 470                 475                 480 


Ala Gly Thr Pro Gly Val Pro Gly Ser Pro Gly Ile Gln Gly Ala Arg 
                485                 490                 495     


Gly Leu Pro Gly Tyr Lys Gly Glu Pro Gly Arg Asp Gly Asp Lys Gly 
            500                 505                 510         


Asp Arg Gly Leu Pro Gly Phe Pro Gly Leu His Gly Met Pro Gly Ser 
        515                 520                 525             


Lys Gly Glu Met Gly Ala Lys Gly Asp Lys Gly Ser Pro Gly Phe Tyr 
    530                 535                 540                 


Gly Lys Lys Gly Ala Lys Gly Glu Lys Gly Asn Ala Gly Phe Pro Gly 
545                 550                 555                 560 


Leu Pro Gly Pro Ala Gly Glu Pro Gly Arg His Gly Lys Asp Gly Leu 
                565                 570                 575     


Met Gly Ser Pro Gly Phe Lys Gly Glu Ala Gly Ser Pro Gly Ala Pro 
            580                 585                 590         


Gly Gln Asp Gly Thr Arg Gly Glu Pro Gly Ile Pro Gly Phe Pro Gly 
        595                 600                 605             


Asn Arg Gly Leu Met Gly Gln Lys Gly Glu Ile Gly Pro Pro Gly Gln 
    610                 615                 620                 


Gln Gly Lys Lys Gly Ala Pro Gly Met Pro Gly Leu Met Gly Ser Asn 
625                 630                 635                 640 


Gly Ser Pro Gly Gln Pro Gly Thr Pro Gly Ser Lys Gly Ser Lys Gly 
                645                 650                 655     


Glu Pro Gly Ile Gln Gly Met Pro Gly Ala Ser Gly Leu Lys Gly Glu 
            660                 665                 670         


Pro Gly Ala Thr Gly Ser Pro Gly Glu Pro Gly Tyr Met Gly Leu Pro 
        675                 680                 685             


Gly Ile Gln Gly Lys Lys Gly Asp Lys Gly Asn Gln Gly Glu Lys Gly 
    690                 695                 700                 


Ile Gln Gly Gln Lys Gly Glu Asn Gly Arg Gln Gly Ile Pro Gly Gln 
705                 710                 715                 720 


Gln Gly Ile Gln Gly His His Gly Ala Lys Gly Glu Arg Gly Glu Lys 
                725                 730                 735     


Gly Glu Pro Gly Val Arg Gly Ala Ile Gly Ser Lys Gly Glu Ser Gly 
            740                 745                 750         


Val Asp Gly Leu Met Gly Pro Ala Gly Pro Lys Gly Gln Pro Gly Asp 
        755                 760                 765             


Pro Gly Pro Gln Gly Pro Pro Gly Leu Asp Gly Lys Pro Gly Arg Glu 
    770                 775                 780                 


Phe Ser Glu Gln Phe Ile Arg Gln Val Cys Thr Asp Val Ile Arg Ala 
785                 790                 795                 800 


Gln Leu Pro Val Leu Leu Gln Ser Gly Arg Ile Arg Asn Cys Asp His 
                805                 810                 815     


Cys Leu Ser Gln His Gly Ser Pro Gly Ile Pro Gly Pro Pro Gly Pro 
            820                 825                 830         


Ile Gly Pro Glu Gly Pro Arg Gly Leu Pro Gly Leu Pro Gly Arg Asp 
        835                 840                 845             


Gly Val Pro Gly Leu Val Gly Val Pro Gly Arg Pro Gly Val Arg Gly 
    850                 855                 860                 


Leu Lys Gly Leu Pro Gly Arg Asn Gly Glu Lys Gly Ser Gln Gly Phe 
865                 870                 875                 880 


Gly Tyr Pro Gly Glu Gln Gly Pro Pro Gly Pro Pro Gly Pro Glu Gly 
                885                 890                 895     


Pro Pro Gly Ile Ser Lys Glu Gly Pro Pro Gly Asp Pro Gly Leu Pro 
            900                 905                 910         


Gly Lys Asp Gly Asp His Gly Lys Pro Gly Ile Gln Gly Gln Pro Gly 
        915                 920                 925             


Pro Pro Gly Ile Cys Asp Pro Ser Leu Cys Phe Ser Val Ile Ala Arg 
    930                 935                 940                 


Arg Asp Pro Phe Arg Lys Gly Pro Asn Tyr 
945                 950                 


<210>  3266
<211>  956
<212>  PRT
<213>  Homo Sapiens

<400>  3266

Met Ala His Tyr Ile Thr Phe Leu Cys Met Val Leu Val Leu Leu Leu 
1               5                   10                  15      


Gln Asn Ser Val Leu Ala Glu Asp Gly Glu Val Arg Ser Ser Cys Arg 
            20                  25                  30          


Thr Ala Pro Thr Asp Leu Val Phe Ile Leu Asp Gly Ser Tyr Ser Val 
        35                  40                  45              


Gly Pro Glu Asn Phe Glu Ile Val Lys Lys Trp Leu Val Asn Ile Thr 
    50                  55                  60                  


Lys Asn Phe Asp Ile Gly Pro Lys Phe Ile Gln Val Gly Val Val Gln 
65                  70                  75                  80  


Tyr Ser Asp Tyr Pro Val Leu Glu Ile Pro Leu Gly Ser Tyr Asp Ser 
                85                  90                  95      


Gly Glu His Leu Thr Ala Ala Val Glu Ser Ile Leu Tyr Leu Gly Gly 
            100                 105                 110         


Asn Thr Lys Thr Gly Lys Ala Ile Gln Phe Ala Leu Asp Tyr Leu Phe 
        115                 120                 125             


Ala Lys Ser Ser Arg Phe Leu Thr Lys Ile Ala Val Val Leu Thr Asp 
    130                 135                 140                 


Gly Lys Ser Gln Asp Asp Val Lys Asp Ala Ala Gln Ala Ala Arg Asp 
145                 150                 155                 160 


Ser Lys Ile Thr Leu Phe Ala Ile Gly Val Gly Ser Glu Thr Glu Asp 
                165                 170                 175     


Ala Glu Leu Arg Ala Ile Ala Asn Lys Pro Ser Ser Thr Tyr Val Phe 
            180                 185                 190         


Tyr Val Glu Asp Tyr Ile Ala Ile Ser Lys Ile Arg Glu Val Met Lys 
        195                 200                 205             


Gln Lys Leu Cys Glu Glu Ser Val Cys Pro Thr Arg Ile Pro Val Ala 
    210                 215                 220                 


Ala Arg Asp Glu Arg Gly Phe Asp Ile Leu Leu Gly Leu Asp Val Asn 
225                 230                 235                 240 


Lys Lys Val Lys Lys Arg Ile Gln Leu Ser Pro Lys Lys Ile Lys Gly 
                245                 250                 255     


Tyr Glu Val Thr Ser Lys Val Asp Leu Ser Glu Leu Thr Ser Asn Val 
            260                 265                 270         


Phe Pro Glu Gly Leu Pro Pro Ser Tyr Val Phe Val Ser Thr Gln Arg 
        275                 280                 285             


Phe Lys Val Lys Lys Ile Trp Asp Leu Trp Arg Ile Leu Thr Ile Asp 
    290                 295                 300                 


Gly Arg Pro Gln Ile Ala Val Thr Leu Asn Gly Val Asp Lys Ile Leu 
305                 310                 315                 320 


Leu Phe Thr Thr Thr Ser Val Ile Asn Gly Ser Gln Val Val Thr Phe 
                325                 330                 335     


Ala Asn Pro Gln Val Lys Thr Leu Phe Asp Glu Gly Trp His Gln Ile 
            340                 345                 350         


Arg Leu Leu Val Thr Glu Gln Asp Val Thr Leu Tyr Ile Asp Asp Gln 
        355                 360                 365             


Gln Ile Glu Asn Lys Pro Leu His Pro Val Leu Gly Ile Leu Ile Asn 
    370                 375                 380                 


Gly Gln Thr Gln Ile Gly Lys Tyr Ser Gly Lys Glu Glu Thr Val Gln 
385                 390                 395                 400 


Phe Asp Val Gln Lys Leu Arg Ile Tyr Cys Asp Pro Glu Gln Asn Asn 
                405                 410                 415     


Arg Glu Thr Ala Cys Glu Ile Pro Gly Phe Val Lys Cys Leu Asn Gly 
            420                 425                 430         


Pro Ser Asp Val Gly Ser Thr Pro Ala Pro Cys Ile Cys Pro Pro Gly 
        435                 440                 445             


Lys Pro Gly Leu Gln Gly Pro Lys Gly Asp Pro Gly Leu Pro Gly Asn 
    450                 455                 460                 


Pro Gly Tyr Pro Gly Gln Pro Gly Gln Asp Gly Lys Pro Gly Tyr Gln 
465                 470                 475                 480 


Gly Ile Ala Gly Thr Pro Gly Val Pro Gly Ser Pro Gly Ile Gln Gly 
                485                 490                 495     


Ala Arg Gly Leu Pro Gly Tyr Lys Gly Glu Pro Gly Arg Asp Gly Asp 
            500                 505                 510         


Lys Gly Asp Arg Gly Leu Pro Gly Phe Pro Gly Leu His Gly Met Pro 
        515                 520                 525             


Gly Ser Lys Gly Glu Met Gly Ala Lys Gly Asp Lys Gly Ser Pro Gly 
    530                 535                 540                 


Phe Tyr Gly Lys Lys Gly Ala Lys Gly Glu Lys Gly Asn Ala Gly Phe 
545                 550                 555                 560 


Pro Gly Leu Pro Gly Pro Ala Gly Glu Pro Gly Arg His Gly Lys Asp 
                565                 570                 575     


Gly Leu Met Gly Ser Pro Gly Phe Lys Gly Glu Ala Gly Ser Pro Gly 
            580                 585                 590         


Ala Pro Gly Gln Asp Gly Thr Arg Gly Glu Pro Gly Ile Pro Gly Phe 
        595                 600                 605             


Pro Gly Asn Arg Gly Leu Met Gly Gln Lys Gly Glu Ile Gly Pro Pro 
    610                 615                 620                 


Gly Gln Gln Gly Lys Lys Gly Ala Pro Gly Met Pro Gly Leu Met Gly 
625                 630                 635                 640 


Ser Asn Gly Ser Pro Gly Gln Pro Gly Thr Pro Gly Ser Lys Gly Ser 
                645                 650                 655     


Lys Gly Glu Pro Gly Ile Gln Gly Met Pro Gly Ala Ser Gly Leu Lys 
            660                 665                 670         


Gly Glu Pro Gly Ala Thr Gly Ser Pro Gly Glu Pro Gly Tyr Met Gly 
        675                 680                 685             


Leu Pro Gly Ile Gln Gly Lys Lys Gly Asp Lys Gly Asn Gln Gly Glu 
    690                 695                 700                 


Lys Gly Ile Gln Gly Gln Lys Gly Glu Asn Gly Arg Gln Gly Ile Pro 
705                 710                 715                 720 


Gly Gln Gln Gly Ile Gln Gly His His Gly Ala Lys Gly Glu Arg Gly 
                725                 730                 735     


Glu Lys Gly Glu Pro Gly Val Arg Gly Ala Ile Gly Ser Lys Gly Glu 
            740                 745                 750         


Ser Gly Val Asp Gly Leu Met Gly Pro Ala Gly Pro Lys Gly Gln Pro 
        755                 760                 765             


Gly Asp Pro Gly Pro Gln Gly Pro Pro Gly Leu Asp Gly Lys Pro Gly 
    770                 775                 780                 


Arg Glu Phe Ser Glu Gln Phe Ile Arg Gln Val Cys Thr Asp Val Ile 
785                 790                 795                 800 


Arg Ala Gln Leu Pro Val Leu Leu Gln Ser Gly Arg Ile Arg Asn Cys 
                805                 810                 815     


Asp His Cys Leu Ser Gln His Gly Ser Pro Gly Ile Pro Gly Pro Pro 
            820                 825                 830         


Gly Pro Ile Gly Pro Glu Gly Pro Arg Gly Leu Pro Gly Leu Pro Gly 
        835                 840                 845             


Arg Asp Gly Val Pro Gly Leu Val Gly Val Pro Gly Arg Pro Gly Val 
    850                 855                 860                 


Arg Gly Leu Lys Gly Leu Pro Gly Arg Asn Gly Glu Lys Gly Ser Gln 
865                 870                 875                 880 


Gly Phe Gly Tyr Pro Gly Glu Gln Gly Pro Pro Gly Pro Pro Gly Pro 
                885                 890                 895     


Glu Gly Pro Pro Gly Ile Ser Lys Glu Gly Pro Pro Gly Asp Pro Gly 
            900                 905                 910         


Leu Pro Gly Lys Asp Gly Asp His Gly Lys Pro Gly Ile Gln Gly Gln 
        915                 920                 925             


Pro Gly Pro Pro Gly Ile Cys Asp Pro Ser Leu Cys Phe Ser Val Ile 
    930                 935                 940                 


Ala Arg Arg Asp Pro Phe Arg Lys Gly Pro Asn Tyr 
945                 950                 955     


<210>  3267
<211>  125
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3267

Xaa Arg Glu Thr Ala Cys Glu Ile Pro Gly Phe Asn Gly Glu Cys Leu 
1               5                   10                  15      


Asn Gly Pro Ser Asp Val Gly Ser Thr Pro Ala Pro Cys Ile Cys Pro 
            20                  25                  30          


Pro Gly Lys Pro Gly Leu Gln Gly Pro Lys Gly Tyr Gln Gly Ile Ala 
        35                  40                  45              


Gly Thr Pro Gly Val Pro Gly Ser Pro Gly Ile Gln Gly Ala Arg Gly 
    50                  55                  60                  


Leu Pro Gly Tyr Lys Gly Glu Pro Gly Arg Asp Gly Asp Lys Gly Asp 
65                  70                  75                  80  


Arg Gly Leu Pro Gly Phe Pro Gly Leu His Gly Met Pro Gly Ser Lys 
                85                  90                  95      


Gly Glu Met Gly Ala Lys Gly Asp Lys Gly Ser Pro Gly Phe Tyr Gly 
            100                 105                 110         


Lys Lys Gly Ser Ile Asp His Thr Thr Lys Tyr Ser Tyr 
        115                 120                 125 


<210>  3268
<211>  65
<212>  PRT
<213>  Homo Sapiens

<400>  3268

Gly Glu Pro Gly Glu Leu Gly Glu Pro Gly Leu Pro Gly Glu Val Gly 
1               5                   10                  15      


Met Arg Gly Pro Gln Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Arg 
            20                  25                  30          


Val Gly Ala Pro Val Ser Glu Gly Thr Cys Leu Gly Arg Gly Ser Thr 
        35                  40                  45              


Pro Ser Pro Gly Ile Lys Asn Gln Val Leu Ala Ser Ser Ser Thr Cys 
    50                  55                  60                  


Ile 
65  


<210>  3269
<211>  1626
<212>  PRT
<213>  Homo Sapiens

<400>  3269

Met Ala Gly Leu Arg Gly Asn Ala Val Ala Gly Leu Leu Trp Met Leu 
1               5                   10                  15      


Leu Leu Trp Ser Gly Gly Gly Gly Cys Gln Ala Gln Arg Ala Gly Cys 
            20                  25                  30          


Lys Ser Val His Tyr Asp Leu Val Phe Leu Leu Asp Thr Ser Ser Ser 
        35                  40                  45              


Val Gly Lys Glu Asp Phe Glu Lys Val Arg Gln Trp Val Ala Asn Leu 
    50                  55                  60                  


Val Asp Thr Phe Glu Val Gly Pro Asp Arg Thr Arg Val Gly Val Val 
65                  70                  75                  80  


Arg Tyr Ser Asp Arg Pro Thr Thr Ala Phe Glu Leu Gly Leu Phe Gly 
                85                  90                  95      


Ser Gln Glu Glu Val Lys Ala Ala Ala Arg Arg Leu Ala Tyr His Gly 
            100                 105                 110         


Gly Asn Thr Asn Thr Gly Asp Ala Leu Arg Tyr Ile Thr Ala Arg Ser 
        115                 120                 125             


Phe Ser Pro His Ala Gly Gly Arg Pro Arg Asp Arg Ala Tyr Lys Gln 
    130                 135                 140                 


Val Ala Ile Leu Leu Thr Asp Gly Arg Ser Gln Asp Leu Val Leu Asp 
145                 150                 155                 160 


Ala Ala Ala Ala Ala His Arg Ala Gly Ile Arg Ile Phe Ala Val Gly 
                165                 170                 175     


Val Gly Glu Ala Leu Lys Glu Glu Leu Glu Glu Ile Ala Ser Glu Pro 
            180                 185                 190         


Lys Ser Ala His Val Phe His Val Ser Asp Phe Asn Ala Ile Asp Lys 
        195                 200                 205             


Ile Arg Gly Lys Leu Arg Arg Arg Leu Cys Glu Asn Val Leu Cys Pro 
    210                 215                 220                 


Ser Val Arg Val Glu Gly Asp Arg Phe Lys His Thr Asn Gly Gly Thr 
225                 230                 235                 240 


Lys Glu Ile Thr Gly Phe Asp Leu Met Asp Leu Phe Ser Val Lys Glu 
                245                 250                 255     


Ile Leu Gly Lys Arg Glu Asn Gly Ala Gln Ser Ser Tyr Val Arg Met 
            260                 265                 270         


Gly Ser Phe Pro Val Val Gln Ser Thr Glu Asp Val Phe Pro Gln Gly 
        275                 280                 285             


Leu Pro Asp Glu Tyr Ala Phe Val Thr Thr Phe Arg Phe Arg Lys Thr 
    290                 295                 300                 


Ser Arg Lys Glu Asp Trp Tyr Ile Trp Gln Val Ile Asp Gln Tyr Ser 
305                 310                 315                 320 


Ile Pro Gln Val Ser Ile Arg Leu Asp Gly Glu Asn Lys Ala Val Glu 
                325                 330                 335     


Tyr Asn Ala Val Gly Ala Met Lys Asp Ala Val Arg Val Val Phe Arg 
            340                 345                 350         


Gly Ser Arg Val Asn Asp Leu Phe Asp Arg Asp Trp His Lys Met Ala 
        355                 360                 365             


Leu Ser Ile Gln Ala Gln Asn Val Ser Leu His Ile Asp Cys Ala Leu 
    370                 375                 380                 


Val Gln Thr Leu Pro Ile Glu Glu Arg Glu Asn Ile Asp Ile Gln Gly 
385                 390                 395                 400 


Lys Thr Val Ile Gly Lys Arg Leu Tyr Asp Ser Val Pro Ile Asp Phe 
                405                 410                 415     


Asp Leu Gln Arg Ile Val Ile Tyr Cys Asp Ser Arg His Ala Glu Leu 
            420                 425                 430         


Glu Thr Cys Cys Asp Ile Pro Ser Gly Pro Cys Gln Val Thr Val Val 
        435                 440                 445             


Thr Glu Pro Pro Pro Pro Pro Pro Pro Gln Arg Pro Pro Thr Pro Gly 
    450                 455                 460                 


Ser Glu Gln Ile Gly Phe Leu Lys Thr Ile Asn Cys Ser Cys Pro Ala 
465                 470                 475                 480 


Gly Glu Lys Gly Glu Met Gly Val Ala Gly Pro Met Gly Leu Pro Gly 
                485                 490                 495     


Pro Lys Gly Asp Ile Gly Ala Ile Gly Pro Val Gly Ala Pro Gly Pro 
            500                 505                 510         


Lys Gly Glu Lys Gly Asp Val Gly Ile Gly Pro Phe Gly Gln Gly Glu 
        515                 520                 525             


Lys Gly Glu Lys Gly Ser Leu Gly Leu Pro Gly Pro Pro Gly Arg Asp 
    530                 535                 540                 


Gly Ser Lys Gly Met Arg Gly Glu Pro Gly Glu Leu Gly Glu Pro Gly 
545                 550                 555                 560 


Leu Pro Gly Glu Val Gly Met Arg Gly Pro Gln Gly Pro Pro Gly Leu 
                565                 570                 575     


Pro Gly Pro Pro Gly Arg Val Gly Ala Pro Gly Leu Gln Gly Glu Arg 
            580                 585                 590         


Gly Glu Lys Gly Thr Arg Gly Glu Lys Gly Glu Arg Gly Leu Asp Gly 
        595                 600                 605             


Phe Pro Gly Lys Pro Gly Asp Thr Gly Gln Gln Gly Arg Pro Gly Pro 
    610                 615                 620                 


Ser Gly Val Ala Gly Pro Gln Gly Glu Lys Gly Asp Val Gly Pro Ala 
625                 630                 635                 640 


Gly Pro Pro Gly Val Pro Gly Ser Val Val Gln Gln Glu Gly Leu Lys 
                645                 650                 655     


Gly Glu Gln Gly Ala Pro Gly Pro Arg Gly His Gln Gly Ala Pro Gly 
            660                 665                 670         


Pro Pro Gly Ala Arg Gly Pro Ile Gly Pro Glu Gly Arg Asp Gly Pro 
        675                 680                 685             


Pro Gly Leu Gln Gly Leu Arg Gly Lys Lys Gly Asp Met Gly Pro Pro 
    690                 695                 700                 


Gly Ile Pro Gly Leu Leu Gly Leu Gln Gly Pro Pro Gly Pro Pro Gly 
705                 710                 715                 720 


Val Pro Gly Pro Pro Gly Pro Gly Gly Ser Pro Gly Leu Pro Gly Glu 
                725                 730                 735     


Ile Gly Phe Pro Gly Lys Pro Gly Pro Pro Gly Pro Thr Gly Pro Pro 
            740                 745                 750         


Gly Lys Asp Gly Pro Asn Gly Pro Pro Gly Pro Pro Gly Thr Lys Gly 
        755                 760                 765             


Glu Pro Gly Glu Arg Gly Glu Asp Gly Leu Pro Gly Lys Pro Gly Leu 
    770                 775                 780                 


Arg Gly Glu Ile Gly Glu Gln Gly Leu Ala Gly Arg Pro Gly Glu Lys 
785                 790                 795                 800 


Gly Glu Ala Gly Leu Pro Gly Ala Pro Gly Phe Pro Gly Val Arg Gly 
                805                 810                 815     


Glu Lys Gly Asp Gln Gly Glu Lys Gly Glu Leu Gly Leu Pro Gly Leu 
            820                 825                 830         


Lys Gly Asp Arg Gly Glu Lys Gly Glu Ala Gly Pro Ala Gly Pro Pro 
        835                 840                 845             


Gly Leu Pro Gly Thr Thr Ser Leu Phe Thr Pro His Pro Arg Met Pro 
    850                 855                 860                 


Gly Glu Gln Gly Pro Lys Gly Glu Lys Gly Asp Pro Gly Leu Pro Gly 
865                 870                 875                 880 


Glu Pro Gly Leu Gln Gly Arg Pro Gly Glu Leu Gly Pro Gln Gly Pro 
                885                 890                 895     


Thr Gly Pro Pro Gly Ala Lys Gly Gln Glu Gly Ala His Gly Ala Pro 
            900                 905                 910         


Gly Ala Ala Gly Asn Pro Gly Ala Pro Gly His Val Gly Ala Pro Gly 
        915                 920                 925             


Pro Ser Gly Pro Pro Gly Ser Val Gly Ala Pro Gly Leu Arg Gly Thr 
    930                 935                 940                 


Pro Gly Lys Asp Gly Glu Arg Gly Glu Lys Gly Ala Ala Gly Glu Glu 
945                 950                 955                 960 


Gly Ser Pro Gly Pro Val Gly Pro Arg Gly Asp Pro Gly Ala Pro Gly 
                965                 970                 975     


Leu Pro Gly Pro Pro Gly Lys Gly Lys Asp Gly Glu Pro Gly Leu Arg 
            980                 985                 990         


Gly Ser Pro Gly Leu Pro Gly Pro  Leu Gly Thr Lys Ala  Ala Cys Gly 
        995                 1000                 1005             


Lys Val  Arg Gly Ser Glu Asn  Cys Ala Leu Gly Gly  Gln Cys Val 
    1010                 1015                 1020             


Lys Gly  Asp Arg Gly Ala Pro  Gly Ile Pro Gly Ser  Pro Gly Ser 
    1025                 1030                 1035             


Arg Gly  Asp Pro Gly Ile Gly  Val Ala Gly Pro Pro  Gly Pro Ser 
    1040                 1045                 1050             


Gly Pro  Pro Gly Asp Lys Gly  Ser Pro Gly Ser Arg  Gly Leu Pro 
    1055                 1060                 1065             


Gly Phe  Pro Gly Pro Gln Gly  Pro Ala Gly Arg Asp  Gly Ala Pro 
    1070                 1075                 1080             


Gly Asn  Pro Gly Glu Arg Gly  Pro Pro Gly Lys Pro  Gly Leu Ser 
    1085                 1090                 1095             


Ser Leu  Leu Ser Pro Gly Asp  Ile Asn Leu Leu Ala  Lys Asp Val 
    1100                 1105                 1110             


Cys Asn  Asp Cys Pro Pro Gly  Pro Pro Gly Leu Pro  Gly Leu Pro 
    1115                 1120                 1125             


Gly Phe  Lys Gly Asp Lys Gly  Val Pro Gly Lys Pro  Gly Arg Glu 
    1130                 1135                 1140             


Gly Thr  Glu Gly Lys Lys Gly  Glu Ala Gly Pro Pro  Gly Leu Pro 
    1145                 1150                 1155             


Gly Pro  Pro Gly Ile Ala Gly  Pro Gln Gly Ser Gln  Gly Glu Arg 
    1160                 1165                 1170             


Gly Ala  Asp Gly Glu Val Gly  Gln Lys Gly Asp Gln  Gly His Pro 
    1175                 1180                 1185             


Gly Val  Pro Gly Phe Met Gly  Pro Pro Gly Asn Pro  Gly Pro Pro 
    1190                 1195                 1200             


Gly Ala  Asp Gly Ile Ala Gly  Ala Ala Gly Pro Pro  Gly Ile Gln 
    1205                 1210                 1215             


Gly Ser  Pro Gly Lys Glu Gly  Pro Pro Gly Pro Gln  Gly Pro Ser 
    1220                 1225                 1230             


Gly Leu  Pro Gly Ile Pro Gly  Glu Glu Gly Lys Glu  Gly Arg Asp 
    1235                 1240                 1245             


Gly Lys  Pro Gly Pro Pro Gly  Glu Pro Gly Lys Ala  Gly Glu Pro 
    1250                 1255                 1260             


Gly Leu  Pro Gly Pro Glu Gly  Ala Arg Gly Pro Pro  Gly Phe Lys 
    1265                 1270                 1275             


Gly His  Thr Gly Asp Ser Gly  Ala Pro Gly Pro Arg  Gly Glu Ser 
    1280                 1285                 1290             


Gly Ala  Met Gly Leu Pro Gly  Gln Glu Gly Leu Pro  Gly Lys Asp 
    1295                 1300                 1305             


Gly Asp  Thr Gly Pro Thr Gly  Pro Gln Gly Pro Gln  Gly Pro Arg 
    1310                 1315                 1320             


Gly Pro  Pro Gly Lys Asn Gly  Ser Pro Gly Ser Pro  Gly Glu Pro 
    1325                 1330                 1335             


Gly Pro  Ser Gly Thr Pro Gly  Gln Lys Gly Ser Lys  Gly Glu Asn 
    1340                 1345                 1350             


Gly Ser  Pro Gly Leu Pro Gly  Phe Leu Gly Pro Arg  Gly Pro Pro 
    1355                 1360                 1365             


Gly Glu  Pro Gly Glu Lys Gly  Val Pro Gly Lys Glu  Gly Val Pro 
    1370                 1375                 1380             


Gly Lys  Pro Gly Glu Pro Gly  Phe Lys Gly Glu Arg  Gly Asp Pro 
    1385                 1390                 1395             


Gly Ile  Lys Gly Asp Lys Gly  Pro Pro Gly Gly Lys  Gly Gln Pro 
    1400                 1405                 1410             


Gly Asp  Pro Gly Ile Pro Gly  His Lys Gly His Thr  Gly Leu Met 
    1415                 1420                 1425             


Gly Pro  Gln Gly Leu Pro Gly  Glu Asn Gly Pro Val  Gly Pro Pro 
    1430                 1435                 1440             


Gly Pro  Pro Gly Gln Pro Gly  Phe Pro Gly Leu Arg  Gly Glu Ser 
    1445                 1450                 1455             


Pro Ser  Met Glu Thr Leu Arg  Arg Leu Ile Gln Glu  Glu Leu Gly 
    1460                 1465                 1470             


Lys Gln  Leu Glu Thr Arg Leu  Ala Tyr Leu Leu Ala  Gln Met Pro 
    1475                 1480                 1485             


Pro Ala  Tyr Met Lys Ser Ser  Gln Gly Arg Pro Gly  Pro Pro Gly 
    1490                 1495                 1500             


Pro Pro  Gly Lys Asp Gly Leu  Pro Gly Arg Ala Gly  Pro Met Gly 
    1505                 1510                 1515             


Glu Pro  Gly Arg Pro Gly Gln  Gly Gly Leu Glu Gly  Pro Ser Gly 
    1520                 1525                 1530             


Pro Ile  Gly Pro Lys Gly Glu  Arg Gly Ala Lys Gly  Asp Pro Gly 
    1535                 1540                 1545             


Ala Pro  Gly Val Gly Leu Arg  Gly Glu Met Gly Pro  Pro Gly Ile 
    1550                 1555                 1560             


Pro Gly  Gln Pro Gly Glu Pro  Gly Tyr Ala Lys Asp  Gly Leu Pro 
    1565                 1570                 1575             


Gly Ile  Pro Gly Pro Gln Gly  Glu Thr Gly Pro Ala  Gly His Pro 
    1580                 1585                 1590             


Gly Leu  Pro Gly Pro Pro Gly  Pro Pro Gly Gln Cys  Asp Pro Ser 
    1595                 1600                 1605             


Gln Cys  Ala Tyr Phe Ala Ser  Leu Ala Ala Arg Pro  Gly Asn Val 
    1610                 1615                 1620             


Lys Gly  Pro 
    1625     


<210>  3270
<211>  1319
<212>  PRT
<213>  Homo Sapiens

<400>  3270

Met Ala Gly Leu Arg Gly Asn Ala Val Ala Gly Leu Leu Trp Met Leu 
1               5                   10                  15      


Leu Leu Trp Ser Gly Gly Gly Gly Cys Gln Ala Gln Arg Ala Gly Cys 
            20                  25                  30          


Lys Ser Val His Tyr Asp Leu Val Phe Leu Leu Asp Thr Ser Ser Ser 
        35                  40                  45              


Val Gly Lys Glu Asp Phe Glu Lys Val Arg Gln Trp Val Ala Asn Leu 
    50                  55                  60                  


Val Asp Thr Phe Glu Val Gly Pro Asp Arg Thr Arg Val Gly Val Val 
65                  70                  75                  80  


Arg Tyr Ser Asp Arg Pro Thr Thr Ala Phe Glu Leu Gly Leu Phe Gly 
                85                  90                  95      


Ser Gln Glu Glu Val Lys Ala Ala Ala Arg Arg Leu Ala Tyr His Gly 
            100                 105                 110         


Gly Asn Thr Asn Thr Gly Asp Ala Leu Arg Tyr Ile Thr Ala Arg Ser 
        115                 120                 125             


Phe Ser Pro His Ala Gly Gly Arg Pro Arg Asp Arg Ala Tyr Lys Gln 
    130                 135                 140                 


Val Ala Ile Leu Leu Thr Asp Gly Arg Ser Gln Asp Leu Val Leu Asp 
145                 150                 155                 160 


Ala Ala Ala Ala Ala His Arg Ala Gly Ile Arg Ile Phe Ala Val Gly 
                165                 170                 175     


Val Gly Glu Ala Leu Lys Glu Glu Leu Glu Glu Ile Ala Ser Glu Pro 
            180                 185                 190         


Lys Ser Ala His Val Phe His Val Ser Asp Phe Asn Ala Ile Asp Lys 
        195                 200                 205             


Ile Arg Gly Lys Leu Arg Arg Arg Leu Cys Glu Asn Val Leu Cys Pro 
    210                 215                 220                 


Ser Val Arg Val Glu Gly Asp Arg Phe Lys His Thr Asn Gly Gly Thr 
225                 230                 235                 240 


Lys Glu Ile Thr Gly Phe Asp Leu Met Asp Leu Phe Ser Val Lys Glu 
                245                 250                 255     


Ile Leu Gly Lys Arg Glu Asn Gly Ala Gln Ser Ser Tyr Val Arg Met 
            260                 265                 270         


Gly Ser Phe Pro Val Val Gln Ser Thr Glu Asp Val Phe Pro Gln Gly 
        275                 280                 285             


Leu Pro Asp Glu Tyr Ala Phe Val Thr Thr Phe Arg Phe Arg Lys Thr 
    290                 295                 300                 


Ser Arg Lys Glu Asp Trp Tyr Ile Trp Gln Val Ile Asp Gln Tyr Ser 
305                 310                 315                 320 


Ile Pro Gln Val Ser Ile Arg Leu Asp Gly Glu Asn Lys Ala Val Glu 
                325                 330                 335     


Tyr Asn Ala Val Ala Gly Pro Gln Gly Glu Lys Gly Asp Val Gly Pro 
            340                 345                 350         


Ala Gly Pro Pro Gly Val Pro Gly Ser Val Val Gln Gln Glu Gly Leu 
        355                 360                 365             


Lys Gly Glu Gln Gly Ala Pro Gly Pro Arg Gly His Gln Gly Ala Pro 
    370                 375                 380                 


Gly Pro Pro Gly Ala Arg Gly Pro Ile Gly Pro Glu Gly Arg Asp Gly 
385                 390                 395                 400 


Pro Pro Gly Leu Gln Gly Leu Arg Gly Lys Lys Gly Asp Met Gly Pro 
                405                 410                 415     


Pro Gly Ile Pro Gly Leu Leu Gly Leu Gln Gly Pro Pro Gly Pro Pro 
            420                 425                 430         


Gly Val Pro Gly Pro Pro Gly Pro Gly Gly Ser Pro Gly Leu Pro Gly 
        435                 440                 445             


Glu Ile Gly Phe Pro Gly Lys Pro Gly Pro Pro Gly Pro Thr Gly Pro 
    450                 455                 460                 


Pro Gly Lys Asp Gly Pro Asn Gly Pro Pro Gly Pro Pro Gly Thr Lys 
465                 470                 475                 480 


Gly Glu Pro Gly Glu Arg Gly Glu Asp Gly Leu Pro Gly Lys Pro Gly 
                485                 490                 495     


Leu Arg Gly Glu Ile Gly Glu Gln Gly Leu Ala Gly Arg Pro Gly Glu 
            500                 505                 510         


Lys Gly Glu Ala Gly Leu Pro Gly Ala Pro Gly Phe Pro Gly Val Arg 
        515                 520                 525             


Gly Glu Lys Gly Asp Gln Gly Glu Lys Gly Glu Leu Gly Leu Pro Gly 
    530                 535                 540                 


Leu Lys Gly Asp Arg Gly Glu Lys Gly Glu Ala Gly Pro Ala Gly Pro 
545                 550                 555                 560 


Pro Gly Leu Pro Gly Thr Thr Ser Leu Phe Thr Pro His Pro Arg Met 
                565                 570                 575     


Pro Gly Glu Gln Gly Pro Lys Gly Glu Lys Gly Asp Pro Gly Leu Pro 
            580                 585                 590         


Gly Glu Pro Gly Leu Gln Gly Arg Pro Gly Glu Leu Gly Pro Gln Gly 
        595                 600                 605             


Pro Thr Gly Pro Pro Gly Ala Lys Gly Gln Glu Gly Ala His Gly Ala 
    610                 615                 620                 


Pro Gly Ala Ala Gly Asn Pro Gly Ala Pro Gly His Val Gly Ala Pro 
625                 630                 635                 640 


Gly Pro Ser Gly Pro Pro Gly Ser Val Gly Ala Pro Gly Leu Arg Gly 
                645                 650                 655     


Thr Pro Gly Lys Asp Gly Glu Arg Gly Glu Lys Gly Ala Ala Gly Glu 
            660                 665                 670         


Glu Gly Ser Pro Gly Pro Val Gly Pro Arg Gly Asp Pro Gly Ala Pro 
        675                 680                 685             


Gly Leu Pro Gly Pro Pro Gly Lys Gly Lys Asp Gly Glu Pro Gly Leu 
    690                 695                 700                 


Arg Gly Ser Pro Gly Leu Pro Gly Pro Leu Gly Thr Lys Gly Asp Arg 
705                 710                 715                 720 


Gly Ala Pro Gly Ile Pro Gly Ser Pro Gly Ser Arg Gly Asp Pro Gly 
                725                 730                 735     


Ile Gly Val Ala Gly Pro Pro Gly Pro Ser Gly Pro Pro Gly Asp Lys 
            740                 745                 750         


Gly Ser Pro Gly Ser Arg Gly Leu Pro Gly Phe Pro Gly Pro Gln Gly 
        755                 760                 765             


Pro Ala Gly Arg Asp Gly Ala Pro Gly Asn Pro Gly Glu Arg Gly Pro 
    770                 775                 780                 


Pro Gly Lys Pro Gly Leu Ser Ser Leu Leu Ser Pro Gly Asp Ile Asn 
785                 790                 795                 800 


Leu Leu Ala Lys Asp Val Cys Asn Asp Cys Pro Pro Gly Pro Pro Gly 
                805                 810                 815     


Leu Pro Gly Leu Pro Gly Phe Lys Gly Asp Lys Gly Val Pro Gly Lys 
            820                 825                 830         


Pro Gly Arg Glu Gly Thr Glu Gly Lys Lys Gly Glu Ala Gly Pro Pro 
        835                 840                 845             


Gly Leu Pro Gly Pro Pro Gly Ile Ala Gly Pro Gln Gly Ser Gln Gly 
    850                 855                 860                 


Glu Arg Gly Ala Asp Gly Glu Val Gly Gln Lys Gly Asp Gln Gly His 
865                 870                 875                 880 


Pro Gly Val Pro Gly Phe Met Gly Pro Pro Gly Asn Pro Gly Pro Pro 
                885                 890                 895     


Gly Ala Asp Gly Ile Ala Gly Ala Ala Gly Pro Pro Gly Ile Gln Gly 
            900                 905                 910         


Ser Pro Gly Lys Glu Gly Pro Pro Gly Pro Gln Gly Pro Ser Gly Leu 
        915                 920                 925             


Pro Gly Ile Pro Gly Glu Glu Gly Lys Glu Gly Arg Asp Gly Lys Pro 
    930                 935                 940                 


Gly Pro Pro Gly Glu Pro Gly Lys Ala Gly Glu Pro Gly Leu Pro Gly 
945                 950                 955                 960 


Pro Glu Gly Ala Arg Gly Pro Pro Gly Phe Lys Gly His Thr Gly Asp 
                965                 970                 975     


Ser Gly Ala Pro Gly Pro Arg Gly Glu Ser Gly Ala Met Gly Leu Pro 
            980                 985                 990         


Gly Gln Glu Gly Leu Pro Gly Lys  Asp Gly Asp Thr Gly  Pro Thr Gly 
        995                 1000                 1005             


Pro Gln  Gly Pro Gln Gly Pro  Arg Gly Pro Pro Gly  Lys Asn Gly 
    1010                 1015                 1020             


Ser Pro  Gly Ser Pro Gly Glu  Pro Gly Pro Ser Gly  Thr Pro Gly 
    1025                 1030                 1035             


Gln Lys  Gly Ser Lys Gly Glu  Asn Gly Ser Pro Gly  Leu Pro Gly 
    1040                 1045                 1050             


Phe Leu  Gly Pro Arg Gly Pro  Pro Gly Glu Pro Gly  Glu Lys Gly 
    1055                 1060                 1065             


Val Pro  Gly Lys Glu Gly Val  Pro Gly Lys Pro Gly  Glu Pro Gly 
    1070                 1075                 1080             


Phe Lys  Gly Glu Arg Gly Asp  Pro Gly Ile Lys Gly  Asp Lys Gly 
    1085                 1090                 1095             


Pro Pro  Gly Gly Lys Gly Gln  Pro Gly Asp Pro Gly  Ile Pro Gly 
    1100                 1105                 1110             


His Lys  Gly His Thr Gly Leu  Met Gly Pro Gln Gly  Leu Pro Gly 
    1115                 1120                 1125             


Glu Asn  Gly Pro Val Gly Pro  Pro Gly Pro Pro Gly  Gln Pro Gly 
    1130                 1135                 1140             


Phe Pro  Gly Leu Arg Gly Glu  Ser Pro Ser Met Glu  Thr Leu Arg 
    1145                 1150                 1155             


Arg Leu  Ile Gln Glu Glu Leu  Gly Lys Gln Leu Glu  Thr Arg Leu 
    1160                 1165                 1170             


Ala Tyr  Leu Leu Ala Gln Met  Pro Pro Ala Tyr Met  Lys Ser Ser 
    1175                 1180                 1185             


Gln Gly  Arg Pro Gly Pro Pro  Gly Pro Pro Gly Lys  Asp Gly Leu 
    1190                 1195                 1200             


Pro Gly  Arg Ala Gly Pro Met  Gly Glu Pro Gly Arg  Pro Gly Gln 
    1205                 1210                 1215             


Gly Gly  Leu Glu Gly Pro Ser  Gly Pro Ile Gly Pro  Lys Gly Glu 
    1220                 1225                 1230             


Arg Gly  Ala Lys Gly Asp Pro  Gly Ala Pro Gly Val  Gly Leu Arg 
    1235                 1240                 1245             


Gly Glu  Met Gly Pro Pro Gly  Ile Pro Gly Gln Pro  Gly Glu Pro 
    1250                 1255                 1260             


Gly Tyr  Ala Lys Asp Gly Leu  Pro Gly Ile Pro Gly  Pro Gln Gly 
    1265                 1270                 1275             


Glu Thr  Gly Pro Ala Gly His  Pro Gly Leu Pro Gly  Pro Pro Gly 
    1280                 1285                 1290             


Pro Pro  Gly Gln Cys Asp Pro  Ser Gln Cys Ala Tyr  Phe Ala Ser 
    1295                 1300                 1305             


Leu Ala  Ala Arg Pro Gly Asn  Val Lys Gly Pro 
    1310                 1315                 


<210>  3271
<211>  81
<212>  PRT
<213>  Homo Sapiens

<400>  3271

Met His Leu Arg Ala His Arg Thr Arg Arg Gly Lys Val Ser Pro Thr 
1               5                   10                  15      


Ala Lys Thr Lys Ser Leu Leu His Phe Ile Val Leu Cys Val Ala Gly 
            20                  25                  30          


Val Val Val His Ala Gln Glu Gln Gly Ile Asp Ile Leu His Gln Leu 
        35                  40                  45              


Gly Leu Gly Gly Lys Asp Val Arg His Ser Ser Pro Ala Thr Ala Val 
    50                  55                  60                  


Pro Ser Ala Ser Thr Pro Leu Pro Gln Gly Val His Leu Thr Glu Ser 
65                  70                  75                  80  


Gly 
    


<210>  3272
<211>  1714
<212>  PRT
<213>  Homo Sapiens

<400>  3272

Met His Leu Arg Ala His Arg Thr Arg Arg Gly Lys Val Ser Pro Thr 
1               5                   10                  15      


Ala Lys Thr Lys Ser Leu Leu His Phe Ile Val Leu Cys Val Ala Gly 
            20                  25                  30          


Val Val Val His Ala Gln Glu Gln Gly Ile Asp Ile Leu His Gln Leu 
        35                  40                  45              


Gly Leu Gly Gly Lys Asp Val Arg His Ser Ser Pro Ala Thr Ala Val 
    50                  55                  60                  


Pro Ser Ala Ser Thr Pro Leu Pro Gln Gly Val His Leu Thr Glu Ser 
65                  70                  75                  80  


Gly Val Ile Phe Lys Asn Asp Ala Tyr Ile Glu Thr Pro Phe Val Lys 
                85                  90                  95      


Ile Leu Pro Val Asn Leu Gly Gln Pro Phe Thr Ile Leu Thr Gly Leu 
            100                 105                 110         


Gln Ser His Arg Val Asn Asn Ala Phe Leu Phe Ser Ile Arg Asn Lys 
        115                 120                 125             


Asn Arg Leu Gln Leu Gly Val Gln Leu Leu Pro Lys Lys Leu Val Val 
    130                 135                 140                 


His Ile Arg Gly Lys Gln Pro Ala Val Phe Asn Tyr Ser Val His Asp 
145                 150                 155                 160 


Glu Gln Trp His Ser Phe Ala Ile Thr Ile Arg Asn Gln Ser Val Ser 
                165                 170                 175     


Met Phe Val Glu Cys Gly Lys Lys Tyr Phe Ser Thr Glu Thr Ile Pro 
            180                 185                 190         


Glu Val Gln Thr Phe Asp Ser Asn Ser Val Phe Thr Leu Gly Ser Met 
        195                 200                 205             


Asn Asn Asn Ser Ile His Phe Glu Gly Ile Val Cys Gln Leu Asp Ile 
    210                 215                 220                 


Ile Pro Ser Ala Glu Ala Ser Ala Asp Tyr Cys Arg Tyr Val Lys Gln 
225                 230                 235                 240 


Gln Cys Arg Gln Ala Asp Lys Tyr Gln Pro Glu Thr Ser Ile Pro Cys 
                245                 250                 255     


Thr Thr Leu Ile Pro Thr Lys Ile Pro Glu His Ser Pro Pro Pro Lys 
            260                 265                 270         


Leu Phe Ala Glu Lys Val Leu Ser Glu Asp Thr Phe Thr Glu Gly Lys 
        275                 280                 285             


Ser Ile Pro Asn Ile Ile Lys Asn Asp Ser Glu Thr Val Tyr Lys Arg 
    290                 295                 300                 


Gln Glu His Gln Ile Ser Arg Ser Gln Leu Ser Ser Leu Gln Ser Gly 
305                 310                 315                 320 


Asn Val Ser Ala Val Asp Leu Thr Asn His Gly Ile Gln Ala Lys Glu 
                325                 330                 335     


Met Ile Thr Glu Glu Asp Thr Gln Thr Asn Phe Ser Leu Ser Val Thr 
            340                 345                 350         


Thr His Arg Ile Ser Glu Ala Lys Met Asn Thr Lys Glu Lys Phe Ser 
        355                 360                 365             


Ser Leu Leu Asn Met Ser Asp Asn Ile Thr Gln His Asp Asp Arg Val 
    370                 375                 380                 


Thr Gly Leu Ser Leu Phe Lys Lys Met Pro Ser Ile Leu Pro Gln Ile 
385                 390                 395                 400 


Lys Gln Asp Thr Ile Thr Asn Leu Lys Lys Ala Ile Thr Ala Asn Leu 
                405                 410                 415     


His Thr Asn Glu Leu Met Glu Met Gln Pro Ile Leu Asn Thr Ser Leu 
            420                 425                 430         


His Arg Val Thr Asn Glu Pro Ser Val Asp Asn His Leu Asp Leu Arg 
        435                 440                 445             


Lys Glu Gly Glu Phe Tyr Pro Asp Ala Thr Tyr Pro Ile Glu Asn Ser 
    450                 455                 460                 


Tyr Glu Thr Glu Leu Tyr Asp Tyr Tyr Tyr Tyr Glu Asp Leu Asn Thr 
465                 470                 475                 480 


Met Leu Glu Met Glu Tyr Leu Arg Gly Pro Lys Gly Asp Thr Gly Pro 
                485                 490                 495     


Pro Gly Pro Pro Gly Pro Ala Gly Ile Pro Gly Pro Ser Gly Lys Arg 
            500                 505                 510         


Gly Pro Arg Gly Ile Pro Gly Pro His Gly Asn Pro Gly Leu Pro Gly 
        515                 520                 525             


Leu Pro Gly Pro Lys Gly Pro Lys Gly Asp Pro Gly Phe Ser Pro Gly 
    530                 535                 540                 


Gln Pro Val Pro Gly Glu Lys Gly Asp Gln Gly Leu Ser Gly Leu Met 
545                 550                 555                 560 


Gly Pro Pro Gly Met Gln Gly Asp Lys Gly Leu Lys Gly His Pro Gly 
                565                 570                 575     


Leu Pro Gly Leu Pro Gly Glu Gln Gly Ile Pro Gly Phe Ala Gly Asn 
            580                 585                 590         


Ile Gly Ser Pro Gly Tyr Pro Gly Arg Gln Gly Leu Ala Gly Pro Glu 
        595                 600                 605             


Gly Asn Pro Gly Pro Lys Gly Ala Gln Gly Phe Ile Gly Ser Pro Gly 
    610                 615                 620                 


Glu Ala Gly Gln Leu Gly Pro Glu Gly Glu Arg Gly Ile Pro Gly Ile 
625                 630                 635                 640 


Arg Gly Lys Lys Gly Phe Lys Gly Arg Gln Gly Phe Pro Gly Asp Phe 
                645                 650                 655     


Gly Asp Arg Gly Pro Ala Gly Leu Asp Gly Ser Pro Gly Leu Val Gly 
            660                 665                 670         


Gly Thr Gly Pro Pro Gly Phe Pro Gly Leu Arg Gly Ser Val Gly Pro 
        675                 680                 685             


Val Gly Pro Ile Gly Pro Ala Gly Ile Pro Gly Pro Met Gly Leu Ser 
    690                 695                 700                 


Gly Asn Lys Gly Leu Pro Gly Ile Lys Gly Asp Lys Gly Glu Gln Gly 
705                 710                 715                 720 


Thr Ala Gly Glu Leu Gly Glu Pro Gly Tyr Pro Gly Asp Lys Gly Ala 
                725                 730                 735     


Val Gly Leu Pro Gly Pro Pro Gly Met Arg Gly Lys Ser Gly Pro Ser 
            740                 745                 750         


Gly Gln Thr Gly Asp Pro Gly Leu Gln Gly Pro Ser Gly Pro Pro Gly 
        755                 760                 765             


Pro Glu Gly Phe Pro Gly Asp Ile Gly Ile Pro Gly Gln Asn Gly Pro 
    770                 775                 780                 


Glu Gly Pro Lys Gly Leu Leu Gly Asn Arg Gly Pro Pro Gly Pro Pro 
785                 790                 795                 800 


Gly Leu Lys Gly Thr Gln Gly Glu Glu Gly Pro Ile Gly Ala Phe Gly 
                805                 810                 815     


Glu Leu Gly Pro Arg Gly Lys Pro Gly Gln Lys Gly Tyr Ala Gly Glu 
            820                 825                 830         


Pro Gly Pro Glu Gly Leu Lys Gly Glu Val Gly Asp Gln Gly Asn Ile 
        835                 840                 845             


Gly Lys Ile Gly Glu Thr Gly Pro Val Gly Leu Pro Gly Glu Val Gly 
    850                 855                 860                 


Met Thr Gly Ser Ile Gly Glu Lys Gly Glu Arg Gly Ser Pro Gly Pro 
865                 870                 875                 880 


Leu Gly Pro Gln Gly Glu Lys Gly Val Met Gly Tyr Pro Gly Pro Pro 
                885                 890                 895     


Gly Val Pro Gly Pro Ile Gly Pro Leu Gly Leu Pro Gly His Val Gly 
            900                 905                 910         


Ala Arg Gly Pro Pro Gly Ser Gln Gly Pro Lys Gly Gln Arg Gly Ser 
        915                 920                 925             


Arg Gly Pro Asp Gly Leu Leu Gly Glu Gln Gly Ile Gln Gly Ala Lys 
    930                 935                 940                 


Gly Glu Lys Gly Asp Gln Gly Lys Arg Gly Pro His Gly Leu Ile Gly 
945                 950                 955                 960 


Lys Thr Gly Asn Pro Gly Glu Arg Gly Phe Gln Gly Lys Pro Gly Leu 
                965                 970                 975     


Gln Gly Leu Pro Gly Ser Thr Gly Asp Arg Gly Leu Pro Gly Glu Pro 
            980                 985                 990         


Gly Leu Arg Gly Leu Gln Gly Asp  Val Gly Pro Pro Gly  Glu Met Gly 
        995                 1000                 1005             


Met Glu  Gly Pro Pro Gly Thr  Glu Gly Glu Ser Gly  Leu Gln Gly 
    1010                 1015                 1020             


Glu Pro  Gly Ala Lys Gly Asp  Val Gly Thr Ala Gly  Ser Val Gly 
    1025                 1030                 1035             


Gly Thr  Gly Glu Pro Gly Leu  Arg Gly Glu Pro Gly  Ala Pro Gly 
    1040                 1045                 1050             


Glu Glu  Gly Leu Gln Gly Lys  Asp Gly Leu Lys Gly  Val Pro Gly 
    1055                 1060                 1065             


Gly Arg  Gly Leu Pro Gly Glu  Asp Gly Glu Lys Gly  Glu Met Gly 
    1070                 1075                 1080             


Leu Pro  Gly Ile Ile Gly Pro  Leu Gly Arg Ser Gly  Gln Thr Gly 
    1085                 1090                 1095             


Leu Pro  Gly Pro Glu Gly Ile  Val Gly Ile Pro Gly  Gln Arg Gly 
    1100                 1105                 1110             


Arg Pro  Gly Lys Lys Gly Asp  Lys Gly Gln Ile Gly  Pro Thr Gly 
    1115                 1120                 1125             


Glu Val  Gly Ser Arg Gly Pro  Pro Gly Lys Ile Gly  Lys Ser Gly 
    1130                 1135                 1140             


Pro Lys  Gly Ala Arg Gly Thr  Arg Gly Ala Val Gly  His Leu Gly 
    1145                 1150                 1155             


Leu Met  Gly Pro Asp Gly Glu  Pro Gly Ile Pro Gly  Tyr Arg Gly 
    1160                 1165                 1170             


His Gln  Gly Gln Pro Gly Pro  Ser Gly Leu Pro Gly  Pro Lys Gly 
    1175                 1180                 1185             


Glu Lys  Gly Tyr Pro Gly Glu  Asp Ser Thr Val Leu  Gly Pro Pro 
    1190                 1195                 1200             


Gly Pro  Arg Gly Glu Pro Gly  Pro Val Gly Asp Gln  Gly Glu Arg 
    1205                 1210                 1215             


Gly Glu  Pro Gly Ala Glu Gly  Tyr Lys Gly His Val  Gly Val Pro 
    1220                 1225                 1230             


Gly Leu  Arg Gly Ala Thr Gly  Gln Gln Gly Pro Pro  Gly Glu Pro 
    1235                 1240                 1245             


Gly Asp  Gln Gly Glu Gln Gly  Leu Lys Gly Glu Arg  Gly Ser Glu 
    1250                 1255                 1260             


Gly Asn  Lys Gly Lys Lys Gly  Ala Pro Gly Pro Ser  Gly Lys Pro 
    1265                 1270                 1275             


Gly Ile  Pro Gly Leu Gln Gly  Leu Leu Gly Pro Lys  Gly Ile Gln 
    1280                 1285                 1290             


Gly Tyr  His Gly Ala Asp Gly  Ile Ser Gly Asn Pro  Gly Lys Ile 
    1295                 1300                 1305             


Gly Pro  Pro Gly Lys Gln Gly  Leu Pro Gly Ile Arg  Gly Gly Pro 
    1310                 1315                 1320             


Gly Arg  Thr Gly Leu Ala Gly  Ala Pro Gly Pro Pro  Gly Val Lys 
    1325                 1330                 1335             


Gly Ser  Ser Gly Leu Pro Gly  Ser Pro Gly Ile Gln  Gly Pro Lys 
    1340                 1345                 1350             


Gly Glu  Gln Gly Leu Pro Gly  Gln Pro Gly Ile Gln  Gly Lys Arg 
    1355                 1360                 1365             


Gly His  Arg Gly Ala Gln Gly  Asp Gln Gly Pro Cys  Gly Asp Pro 
    1370                 1375                 1380             


Gly Leu  Lys Gly Gln Pro Gly  Glu Tyr Gly Val Gln  Gly Leu Thr 
    1385                 1390                 1395             


Gly Phe  Gln Gly Phe Pro Gly  Pro Lys Gly Pro Glu  Gly Asp Ala 
    1400                 1405                 1410             


Gly Ile  Val Gly Ile Ser Gly  Pro Lys Gly Pro Ile  Gly His Arg 
    1415                 1420                 1425             


Gly Asn  Thr Gly Pro Leu Gly  Arg Glu Gly Ile Ile  Gly Pro Thr 
    1430                 1435                 1440             


Gly Arg  Thr Gly Pro Arg Gly  Glu Lys Gly Phe Arg  Gly Glu Thr 
    1445                 1450                 1455             


Gly Pro  Gln Gly Pro Arg Gly  Gln Pro Gly Pro Pro  Gly Pro Pro 
    1460                 1465                 1470             


Gly Ala  Pro Gly Pro Arg Lys  Gln Met Asp Ile Asn  Ala Ala Ile 
    1475                 1480                 1485             


Gln Ala  Leu Ile Glu Ser Asn  Thr Ala Leu Gln Met  Glu Ser Tyr 
    1490                 1495                 1500             


Gln Asn  Thr Glu Val Thr Leu  Ile Asp His Ser Glu  Glu Ile Phe 
    1505                 1510                 1515             


Lys Thr  Leu Asn Tyr Leu Ser  Asn Leu Leu His Ser  Ile Lys Asn 
    1520                 1525                 1530             


Pro Leu  Gly Thr Arg Asp Asn  Pro Ala Arg Ile Cys  Lys Asp Leu 
    1535                 1540                 1545             


Leu Asn  Cys Glu Gln Lys Val  Ser Asp Gly Lys Tyr  Trp Ile Asp 
    1550                 1555                 1560             


Pro Asn  Leu Gly Cys Pro Ser  Asp Ala Ile Glu Val  Phe Cys Asn 
    1565                 1570                 1575             


Phe Ser  Ala Gly Gly Gln Thr  Cys Leu Pro Pro Val  Ser Val Thr 
    1580                 1585                 1590             


Lys Leu  Glu Phe Gly Val Gly  Lys Val Gln Met Asn  Phe Leu His 
    1595                 1600                 1605             


Leu Leu  Ser Ser Glu Ala Thr  His Ile Ile Thr Ile  His Cys Leu 
    1610                 1615                 1620             


Asn Thr  Pro Arg Trp Thr Ser  Thr Gln Thr Ser Gly  Pro Gly Leu 
    1625                 1630                 1635             


Pro Ile  Gly Phe Lys Gly Trp  Asn Gly Gln Ile Phe  Lys Val Asn 
    1640                 1645                 1650             


Thr Leu  Leu Glu Pro Lys Val  Leu Ser Asp Asp Cys  Lys Ile Gln 
    1655                 1660                 1665             


Asp Gly  Ser Trp His Lys Ala  Thr Phe Leu Phe His  Thr Gln Glu 
    1670                 1675                 1680             


Pro Asn  Gln Leu Pro Val Ile  Glu Val Gln Lys Leu  Pro His Leu 
    1685                 1690                 1695             


Lys Thr  Glu Arg Lys Tyr Tyr  Ile Asp Ser Ser Ser  Val Cys Phe 
    1700                 1705                 1710             


Leu 
    


<210>  3273
<211>  890
<212>  PRT
<213>  Homo Sapiens

<400>  3273

Met His Leu Arg Ala His Arg Thr Arg Arg Gly Lys Val Ser Pro Thr 
1               5                   10                  15      


Ala Lys Thr Lys Ser Leu Leu His Phe Ile Val Leu Cys Val Ala Gly 
            20                  25                  30          


Val Val Val His Ala Gln Glu Gln Gly Ile Asp Ile Leu His Gln Leu 
        35                  40                  45              


Gly Leu Gly Gly Lys Asp Val Arg His Ser Ser Pro Ala Thr Ala Val 
    50                  55                  60                  


Pro Ser Ala Ser Thr Pro Leu Pro Gln Gly Val His Leu Thr Glu Ser 
65                  70                  75                  80  


Gly Val Ile Phe Lys Asn Asp Ala Tyr Ile Glu Thr Pro Phe Val Lys 
                85                  90                  95      


Ile Leu Pro Val Asn Leu Gly Gln Pro Phe Thr Ile Leu Thr Gly Leu 
            100                 105                 110         


Gln Ser His Arg Val Asn Asn Ala Phe Leu Phe Ser Ile Arg Asn Lys 
        115                 120                 125             


Asn Arg Leu Gln Leu Gly Val Gln Leu Leu Pro Lys Lys Leu Val Val 
    130                 135                 140                 


His Ile Arg Gly Lys Gln Pro Ala Val Phe Asn Tyr Ser Val His Asp 
145                 150                 155                 160 


Glu Gln Trp His Ser Phe Ala Ile Thr Ile Arg Asn Gln Ser Val Ser 
                165                 170                 175     


Met Phe Val Glu Cys Gly Lys Lys Tyr Phe Ser Thr Glu Thr Ile Pro 
            180                 185                 190         


Glu Val Gln Thr Phe Asp Ser Asn Ser Val Phe Thr Leu Gly Ser Met 
        195                 200                 205             


Asn Asn Asn Ser Ile His Phe Glu Gly Ile Val Cys Gln Leu Asp Ile 
    210                 215                 220                 


Ile Pro Ser Ala Glu Ala Ser Ala Asp Tyr Cys Arg Tyr Val Lys Gln 
225                 230                 235                 240 


Gln Cys Arg Gln Ala Asp Lys Tyr Gln Pro Glu Thr Ser Ile Pro Cys 
                245                 250                 255     


Thr Thr Leu Ile Pro Thr Lys Ile Pro Glu His Ser Pro Pro Pro Lys 
            260                 265                 270         


Leu Phe Ala Glu Lys Val Leu Ser Glu Asp Thr Phe Thr Glu Gly Lys 
        275                 280                 285             


Ser Ile Pro Asn Ile Ile Lys Asn Asp Ser Glu Thr Val Tyr Lys Arg 
    290                 295                 300                 


Gln Glu His Gln Ile Ser Arg Ser Gln Leu Ser Ser Leu Gln Ser Gly 
305                 310                 315                 320 


Asn Val Ser Ala Val Asp Leu Thr Asn His Gly Ile Gln Ala Lys Glu 
                325                 330                 335     


Met Ile Thr Glu Glu Asp Thr Gln Thr Asn Phe Ser Leu Ser Val Thr 
            340                 345                 350         


Thr His Arg Ile Ser Glu Ala Lys Met Asn Thr Lys Glu Lys Phe Ser 
        355                 360                 365             


Ser Leu Leu Asn Met Ser Asp Asn Ile Thr Gln His Asp Asp Arg Val 
    370                 375                 380                 


Thr Gly Leu Ser Leu Phe Lys Lys Met Pro Ser Ile Leu Pro Gln Ile 
385                 390                 395                 400 


Lys Gln Asp Thr Ile Thr Asn Leu Lys Lys Ala Ile Thr Ala Asn Leu 
                405                 410                 415     


His Thr Asn Glu Leu Met Glu Met Gln Pro Ile Leu Asn Thr Ser Leu 
            420                 425                 430         


His Arg Val Thr Asn Glu Pro Ser Val Asp Asn His Leu Asp Leu Arg 
        435                 440                 445             


Lys Glu Gly Glu Phe Tyr Pro Asp Ala Thr Tyr Pro Ile Glu Asn Ser 
    450                 455                 460                 


Tyr Glu Thr Glu Leu Tyr Asp Tyr Tyr Tyr Tyr Glu Asp Leu Asn Thr 
465                 470                 475                 480 


Met Leu Glu Met Glu Tyr Leu Arg Gly Pro Lys Gly Asp Thr Gly Pro 
                485                 490                 495     


Pro Gly Pro Pro Gly Pro Ala Gly Ile Pro Gly Pro Ser Gly Lys Arg 
            500                 505                 510         


Gly Pro Arg Gly Ile Pro Gly Pro His Gly Asn Pro Gly Leu Pro Gly 
        515                 520                 525             


Leu Pro Gly Pro Lys Gly Pro Lys Gly Asp Pro Gly Phe Ser Pro Gly 
    530                 535                 540                 


Gln Pro Val Pro Gly Glu Lys Gly Asp Gln Gly Leu Ser Gly Leu Met 
545                 550                 555                 560 


Gly Pro Pro Gly Met Gln Gly Asp Lys Gly Leu Lys Gly His Pro Gly 
                565                 570                 575     


Leu Pro Gly Leu Pro Gly Glu Gln Gly Ile Pro Gly Phe Ala Gly Asn 
            580                 585                 590         


Ile Gly Ser Pro Gly Tyr Pro Gly Arg Gln Gly Leu Ala Gly Pro Glu 
        595                 600                 605             


Gly Asn Pro Gly Pro Lys Gly Ala Gln Gly Phe Ile Gly Ser Pro Gly 
    610                 615                 620                 


Glu Ala Gly Gln Leu Gly Pro Glu Gly Glu Arg Gly Ile Pro Gly Ile 
625                 630                 635                 640 


Arg Gly Lys Lys Gly Phe Lys Gly Arg Gln Gly Phe Pro Gly Asp Phe 
                645                 650                 655     


Gly Asp Arg Gly Pro Ala Gly Leu Asp Gly Ser Pro Gly Leu Val Gly 
            660                 665                 670         


Gly Thr Gly Pro Pro Gly Phe Pro Gly Leu Arg Gly Ser Val Gly Pro 
        675                 680                 685             


Val Gly Pro Ile Gly Pro Ala Gly Ile Pro Gly Pro Met Gly Leu Ser 
    690                 695                 700                 


Gly Asn Lys Gly Leu Pro Gly Ile Lys Gly Asp Lys Gly Glu Gln Gly 
705                 710                 715                 720 


Thr Ala Gly Glu Leu Gly Glu Pro Gly Tyr Pro Gly Asp Lys Gly Ala 
                725                 730                 735     


Val Gly Leu Pro Gly Pro Pro Gly Met Arg Gly Lys Ser Gly Pro Ser 
            740                 745                 750         


Gly Gln Thr Gly Asp Pro Gly Leu Gln Gly Pro Ser Gly Pro Pro Gly 
        755                 760                 765             


Pro Glu Gly Phe Pro Gly Asp Ile Gly Ile Pro Gly Gln Asn Gly Pro 
    770                 775                 780                 


Glu Gly Pro Lys Gly Leu Leu Gly Asn Arg Gly Pro Pro Gly Pro Pro 
785                 790                 795                 800 


Gly Leu Lys Gly Thr Gln Gly Glu Glu Gly Pro Ile Gly Ala Phe Gly 
                805                 810                 815     


Glu Leu Gly Pro Arg Gly Lys Pro Gly Gln Lys Gly Tyr Ala Gly Glu 
            820                 825                 830         


Pro Gly Pro Glu Gly Leu Lys Gly Glu Val Gly Asp Gln Gly Asn Ile 
        835                 840                 845             


Gly Lys Ile Gly Glu Thr Met Glu Ser Cys Ser Val Thr Gln Ala Gly 
    850                 855                 860                 


Ala Gln Trp His Asp Leu Gly Ser Leu His Pro Leu Pro Pro Gly Phe 
865                 870                 875                 880 


Lys Arg Phe Ser Cys Leu Ser Leu Pro Gly 
                885                 890 


<210>  3274
<211>  166
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3274

Xaa Ile Lys Asn Pro Leu Gly Thr Arg Asp Asn Pro Ala Arg Ile Cys 
1               5                   10                  15      


Lys Asp Leu Leu Asn Cys Glu Gln Lys Val Ser Asp Gly Lys Tyr Trp 
            20                  25                  30          


Ile Asp Pro Asn Leu Gly Cys Pro Ser Asp Ala Ile Glu Val Phe Cys 
        35                  40                  45              


Asn Phe Ser Ala Gly Gly Gln Thr Cys Leu Pro Pro Val Ser Val Thr 
    50                  55                  60                  


Lys Ala Phe Thr Ile Ile Thr Pro Glu Ile Glu Glu Gly Arg Ile Leu 
65                  70                  75                  80  


Pro Phe Leu Gly Asn His Glu Pro Leu Ile Lys Ser Ser Met Ile Val 
                85                  90                  95      


Leu Leu Pro Lys Tyr Pro His His His Pro His Ser Ser Gly Ser Trp 
            100                 105                 110         


His Arg Ile Ile Ile Glu Gly Lys Lys Met Gly Leu Cys Glu Leu Cys 
        115                 120                 125             


Arg Gly Asn Arg Ser Ser Gly Glu Ala Asp Ser Ser Cys Phe His Asp 
    130                 135                 140                 


Gln Ile Thr Ser Leu Ile Ser Leu Ile His Lys Leu Asn Pro Arg Lys 
145                 150                 155                 160 


Thr Arg Glu Val Leu Gly 
                165     


<210>  3275
<211>  439
<212>  PRT
<213>  Homo Sapiens

<400>  3275

Met Lys Leu Ala Leu Leu Leu Pro Trp Ala Cys Cys Cys Leu Cys Gly 
1               5                   10                  15      


Ser Ala Leu Ala Thr Gly Phe Leu Tyr Pro Phe Ser Ala Ala Ala Leu 
            20                  25                  30          


Gln Gln His Gly Tyr Pro Glu Pro Gly Ala Gly Ser Pro Gly Ser Gly 
        35                  40                  45              


Tyr Ala Ser Arg Arg His Trp Cys His His Thr Val Thr Arg Thr Val 
    50                  55                  60                  


Ser Cys Gln Val Gln Asn Gly Ser Glu Thr Val Val Gln Arg Val Tyr 
65                  70                  75                  80  


Gln Ser Cys Arg Trp Pro Gly Pro Cys Ala Asn Leu Val Arg Thr Leu 
                85                  90                  95      


Ile Arg Pro Thr Tyr Arg Val Ser Tyr Arg Thr Val Thr Val Leu Glu 
            100                 105                 110         


Trp Arg Cys Cys Pro Gly Phe Thr Gly Ser Asn Cys Asp Glu Glu Cys 
        115                 120                 125             


Met Asn Cys Thr Arg Leu Ser Asp Met Ser Glu Arg Leu Thr Thr Leu 
    130                 135                 140                 


Glu Ala Lys Val Leu Leu Leu Glu Ala Ala Glu Arg Pro Ser Ser Pro 
145                 150                 155                 160 


Asp Asn Asp Leu Pro Ala Pro Glu Ser Thr Pro Pro Thr Trp Asn Glu 
                165                 170                 175     


Asp Phe Leu Pro Asp Ala Ile Pro Leu Ala His Pro Val Pro Arg Gln 
            180                 185                 190         


Arg Arg Pro Thr Gly Pro Ala Gly Pro Pro Gly Gln Thr Gly Pro Pro 
        195                 200                 205             


Gly Pro Ala Gly Pro Pro Gly Ser Lys Gly Asp Arg Gly Gln Thr Gly 
    210                 215                 220                 


Glu Lys Gly Pro Ala Gly Pro Pro Gly Leu Leu Gly Pro Pro Gly Pro 
225                 230                 235                 240 


Arg Gly Leu Pro Gly Glu Met Gly Arg Pro Gly Pro Pro Gly Pro Pro 
                245                 250                 255     


Gly Pro Ala Gly Asn Pro Gly Pro Ser Pro Asn Ser Pro Gln Gly Ala 
            260                 265                 270         


Leu Tyr Ser Leu Gln Pro Pro Thr Asp Lys Asp Asn Gly Asp Ser Arg 
        275                 280                 285             


Leu Ala Ser Ala Ile Val Asp Thr Val Leu Ala Gly Val Pro Gly Pro 
    290                 295                 300                 


Arg Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly Pro Pro 
305                 310                 315                 320 


Gly Pro Pro Gly Thr Pro Gly Ser Gln Gly Leu Ala Gly Glu Arg Gly 
                325                 330                 335     


Thr Val Gly Pro Ser Gly Glu Pro Gly Val Lys Gly Glu Glu Gly Glu 
            340                 345                 350         


Lys Ala Ala Thr Ala Glu Gly Glu Gly Val Gln Gln Leu Arg Glu Ala 
        355                 360                 365             


Leu Lys Ile Leu Ala Glu Arg Val Leu Ile Leu Glu His Met Ile Gly 
    370                 375                 380                 


Ile His Asp Pro Leu Ala Ser Pro Glu Gly Gly Ser Gly Gln Asp Ala 
385                 390                 395                 400 


Ala Leu Arg Ala Asn Leu Lys Met Lys Arg Gly Gly Ala Gln Pro Asp 
                405                 410                 415     


Gly Val Leu Ala Ala Leu Leu Gly Pro Asp Pro Gly Gln Lys Ser Val 
            420                 425                 430         


Asp Gln Ala Ser Ser Arg Lys 
        435                 


<210>  3276
<211>  441
<212>  PRT
<213>  Homo Sapiens

<400>  3276

Met Lys Leu Ala Leu Leu Leu Pro Trp Ala Cys Cys Cys Leu Cys Gly 
1               5                   10                  15      


Ser Ala Leu Ala Thr Gly Phe Leu Tyr Pro Phe Ser Ala Ala Ala Leu 
            20                  25                  30          


Gln Gln His Gly Tyr Pro Glu Pro Gly Ala Gly Ser Pro Gly Ser Gly 
        35                  40                  45              


Tyr Ala Ser Arg Arg His Trp Cys His His Thr Val Thr Arg Thr Val 
    50                  55                  60                  


Ser Cys Gln Val Gln Asn Gly Ser Glu Thr Val Val Gln Arg Val Tyr 
65                  70                  75                  80  


Gln Ser Cys Arg Trp Pro Gly Pro Cys Ala Asn Leu Val Ser Tyr Arg 
                85                  90                  95      


Thr Leu Ile Arg Pro Thr Tyr Arg Val Ser Tyr Arg Thr Val Thr Val 
            100                 105                 110         


Leu Glu Trp Arg Cys Cys Pro Gly Phe Thr Gly Ser Asn Cys Asp Glu 
        115                 120                 125             


Glu Cys Met Asn Cys Thr Arg Leu Ser Asp Met Ser Glu Arg Leu Thr 
    130                 135                 140                 


Thr Leu Glu Ala Lys Val Leu Leu Leu Glu Ala Ala Glu Arg Pro Ser 
145                 150                 155                 160 


Ser Pro Asp Asn Asp Leu Pro Ala Pro Glu Ser Thr Pro Pro Thr Trp 
                165                 170                 175     


Asn Glu Asp Phe Leu Pro Asp Ala Ile Pro Leu Ala His Pro Val Pro 
            180                 185                 190         


Arg Gln Arg Arg Pro Thr Gly Pro Ala Gly Pro Pro Gly Gln Thr Gly 
        195                 200                 205             


Pro Pro Gly Pro Ala Gly Pro Pro Gly Ser Lys Gly Asp Arg Gly Gln 
    210                 215                 220                 


Thr Gly Glu Lys Gly Pro Ala Gly Pro Pro Gly Leu Leu Gly Pro Pro 
225                 230                 235                 240 


Gly Pro Arg Gly Leu Pro Gly Glu Met Gly Arg Pro Gly Pro Pro Gly 
                245                 250                 255     


Pro Pro Gly Pro Ala Gly Asn Pro Gly Pro Ser Pro Asn Ser Pro Gln 
            260                 265                 270         


Gly Ala Leu Tyr Ser Leu Gln Pro Pro Thr Asp Lys Asp Asn Gly Asp 
        275                 280                 285             


Ser Arg Leu Ala Ser Ala Ile Val Asp Thr Val Leu Ala Gly Val Pro 
    290                 295                 300                 


Gly Pro Arg Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly 
305                 310                 315                 320 


Pro Pro Gly Pro Pro Gly Thr Pro Gly Ser Gln Gly Leu Ala Gly Glu 
                325                 330                 335     


Arg Gly Thr Val Gly Pro Ser Gly Glu Pro Gly Val Lys Gly Glu Glu 
            340                 345                 350         


Gly Glu Lys Ala Ala Thr Ala Glu Gly Glu Gly Val Gln Gln Leu Arg 
        355                 360                 365             


Glu Ala Leu Lys Ile Leu Ala Glu Arg Val Leu Ile Leu Glu His Met 
    370                 375                 380                 


Ile Gly Ile His Asp Pro Leu Ala Ser Pro Glu Gly Gly Ser Gly Gln 
385                 390                 395                 400 


Asp Ala Ala Leu Arg Ala Asn Leu Lys Met Lys Arg Gly Gly Ala Gln 
                405                 410                 415     


Pro Asp Gly Val Leu Ala Ala Leu Leu Gly Pro Asp Pro Gly Gln Lys 
            420                 425                 430         


Ser Val Asp Gln Ala Ser Ser Arg Lys 
        435                 440     


<210>  3277
<211>  714
<212>  PRT
<213>  Homo Sapiens

<400>  3277

Leu Ser Trp Thr Lys Ala Gly Ser Pro Ala Pro Pro Gly Val Ile Pro 
1               5                   10                  15      


Phe Gln Ser Gly Phe Ile Phe Thr Gln Arg Ala Arg Leu Gln Ala Pro 
            20                  25                  30          


Thr Gly Thr Val Ile Pro Ala Ala Leu Gly Thr Glu Leu Ala Leu Val 
        35                  40                  45              


Leu Ser Leu Cys Ser His Arg Val Asn His Ala Phe Leu Phe Ala Val 
    50                  55                  60                  


Arg Ser Gln Lys Arg Lys Leu Gln Leu Gly Leu Gln Phe Leu Pro Gly 
65                  70                  75                  80  


Lys Thr Val Val His Leu Gly Ser Arg Arg Ser Val Ala Phe Asp Leu 
                85                  90                  95      


Asp Met His Asp Gly Arg Trp His His Leu Ala Leu Glu Leu Arg Gly 
            100                 105                 110         


Arg Thr Val Thr Leu Val Thr Ala Cys Gly Gln Arg Arg Val Pro Val 
        115                 120                 125             


Leu Leu Pro Phe His Arg Asp Pro Ala Leu Asp Pro Gly Gly Ser Phe 
    130                 135                 140                 


Leu Phe Gly Lys Met Asn Pro His Ala Val Gln Phe Glu Gly Ala Leu 
145                 150                 155                 160 


Cys Gln Phe Ser Ile Tyr Pro Val Thr Gln Val Ala His Asn Tyr Cys 
                165                 170                 175     


Thr His Leu Arg Lys Gln Cys Gly Gln Ala Asp Thr Tyr Gln Ser Pro 
            180                 185                 190         


Leu Gly Pro Leu Phe Ser Gln Asp Ser Gly Arg Pro Phe Thr Phe Gln 
        195                 200                 205             


Ser Asp Leu Ala Leu Leu Gly Leu Glu Asn Leu Thr Thr Ala Thr Pro 
    210                 215                 220                 


Ala Leu Gly Ser Leu Pro Ala Gly Arg Gly Pro Arg Gly Thr Val Ala 
225                 230                 235                 240 


Pro Ala Thr Pro Thr Lys Pro Gln Arg Thr Ser Pro Thr Asn Pro His 
                245                 250                 255     


Gln His Met Ala Val Gly Gly Pro Ala Gln Thr Pro Leu Leu Pro Ala 
            260                 265                 270         


Lys Leu Ser Ala Ser Asn Ala Leu Asp Pro Met Leu Pro Ala Ser Val 
        275                 280                 285             


Gly Gly Ser Thr Arg Thr Pro Arg Pro Ala Ala Ala Gln Pro Ser Gln 
    290                 295                 300                 


Lys Ile Thr Ala Thr Lys Ile Pro Lys Ser Leu Pro Thr Lys Pro Ser 
305                 310                 315                 320 


Ala Pro Ser Thr Ser Ile Val Pro Ile Lys Ser Pro His Pro Thr Gln 
                325                 330                 335     


Lys Thr Ala Pro Ser Ser Phe Thr Lys Ser Ala Leu Pro Thr Gln Lys 
            340                 345                 350         


Gln Val Pro Pro Thr Ser Arg Pro Val Pro Ala Arg Val Ser Arg Pro 
        355                 360                 365             


Ala Glu Lys Pro Ile Gln Arg Asn Pro Gly Met Pro Arg Pro Pro Pro 
    370                 375                 380                 


Pro Ser Thr Arg Pro Leu Pro Pro Thr Thr Ser Ser Ser Lys Lys Pro 
385                 390                 395                 400 


Ile Pro Thr Leu Ala Arg Thr Glu Ala Lys Ile Thr Ser His Ala Ser 
                405                 410                 415     


Lys Pro Ala Ser Ala Arg Thr Ser Thr His Lys Pro Pro Pro Phe Thr 
            420                 425                 430         


Ala Leu Ser Ser Ser Pro Ala Pro Thr Pro Gly Ser Thr Arg Ser Thr 
        435                 440                 445             


Arg Pro Pro Ala Thr Met Val Pro Pro Thr Ser Gly Thr Ser Thr Pro 
    450                 455                 460                 


Arg Thr Ala Pro Ala Val Pro Thr Pro Gly Ser Ala Pro Thr Gly Ser 
465                 470                 475                 480 


Lys Lys Pro Ile Gly Ser Glu Ala Ser Lys Lys Ala Gly Pro Lys Ser 
                485                 490                 495     


Ser Pro Arg Lys Pro Val Pro Leu Arg Pro Gly Lys Ala Ala Arg Asp 
            500                 505                 510         


Val Pro Leu Ser Asp Leu Thr Thr Arg Pro Ser Pro Arg Gln Pro Gln 
        515                 520                 525             


Pro Ser Gln Gln Thr Thr Pro Ala Leu Val Leu Ala Pro Ala Gln Phe 
    530                 535                 540                 


Leu Ser Ser Ser Pro Arg Pro Thr Ser Ser Gly Tyr Ser Ile Phe His 
545                 550                 555                 560 


Leu Ala Gly Ser Thr Pro Phe Pro Leu Leu Met Gly Pro Pro Gly Pro 
                565                 570                 575     


Lys Gly Asp Cys Gly Leu Pro Gly Pro Pro Gly Leu Pro Gly Leu Pro 
            580                 585                 590         


Gly Ile Pro Gly Ala Arg Gly Pro Arg Gly Pro Pro Gly Pro Tyr Gly 
        595                 600                 605             


Asn Pro Gly Leu Pro Gly Pro Pro Gly Ala Lys Gly Asp Met Gly Leu 
    610                 615                 620                 


Pro Gly Leu Ser Gly Asn Pro Gly Pro Pro Gly Arg Lys Gly Leu Pro 
625                 630                 635                 640 


Gly Pro Val Gly Asp Pro Gly Pro Lys Gly Ser Arg Gly Tyr Ile Gly 
                645                 650                 655     


Leu Pro Gly Leu Phe Gly Leu Pro Gly Ser Asp Gly Glu Arg Gly Leu 
            660                 665                 670         


Pro Gly Val Pro Gly Lys Arg Gly Lys Met Gly Met Pro Val Leu Leu 
        675                 680                 685             


Pro Gln Ser Ser Glu Ala Arg Gly Gly Asn Ser Met Pro Ser Glu Gly 
    690                 695                 700                 


Ala Leu Ala Gly Arg His Gly Ser His Leu 
705                 710                 


<210>  3278
<211>  1860
<212>  PRT
<213>  Homo Sapiens

<400>  3278

Met Gly Ala Gly Ser Ala Arg Gly Ala Arg Gly Thr Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Arg Gly Gly Gly Phe Leu Phe Ser Trp Ile Leu Val Ser Phe 
            20                  25                  30          


Ala Cys His Leu Ala Ser Thr Gln Gly Ala Pro Glu Asp Val Asp Ile 
        35                  40                  45              


Leu Gln Arg Leu Gly Leu Ser Trp Thr Lys Ala Gly Ser Pro Ala Pro 
    50                  55                  60                  


Pro Gly Val Ile Pro Phe Gln Ser Gly Phe Ile Phe Thr Gln Arg Ala 
65                  70                  75                  80  


Arg Leu Gln Ala Pro Thr Gly Thr Val Ile Pro Ala Ala Leu Gly Thr 
                85                  90                  95      


Glu Leu Ala Leu Val Leu Ser Leu Cys Ser His Arg Val Asn His Ala 
            100                 105                 110         


Phe Leu Phe Ala Val Arg Ser Gln Lys Arg Lys Leu Gln Leu Gly Leu 
        115                 120                 125             


Gln Phe Leu Pro Gly Lys Thr Val Val His Leu Gly Ser Arg Arg Ser 
    130                 135                 140                 


Val Ala Phe Asp Leu Asp Met His Asp Gly Arg Trp His His Leu Ala 
145                 150                 155                 160 


Leu Glu Leu Arg Gly Arg Thr Val Thr Leu Val Thr Ala Cys Gly Gln 
                165                 170                 175     


Arg Arg Val Pro Val Leu Leu Pro Phe His Arg Asp Pro Ala Leu Asp 
            180                 185                 190         


Pro Gly Gly Ser Phe Leu Phe Gly Lys Met Asn Pro His Ala Val Gln 
        195                 200                 205             


Phe Glu Gly Ala Leu Cys Gln Phe Ser Ile Tyr Pro Val Thr Gln Val 
    210                 215                 220                 


Ala His Asn Tyr Cys Thr His Leu Arg Lys Gln Cys Gly Gln Ala Asp 
225                 230                 235                 240 


Thr Tyr Gln Ser Pro Leu Gly Pro Leu Phe Ser Gln Asp Ser Gly Arg 
                245                 250                 255     


Pro Phe Thr Phe Gln Ser Asp Leu Ala Leu Leu Gly Leu Glu Asn Leu 
            260                 265                 270         


Thr Thr Ala Thr Pro Ala Leu Gly Ser Leu Pro Ala Gly Arg Gly Pro 
        275                 280                 285             


Arg Gly Thr Val Ala Pro Ala Thr Pro Thr Lys Pro Gln Arg Thr Ser 
    290                 295                 300                 


Pro Thr Asn Pro His Gln His Met Ala Val Gly Gly Pro Ala Gln Thr 
305                 310                 315                 320 


Pro Leu Leu Pro Ala Lys Leu Ser Ala Ser Asn Ala Leu Asp Pro Met 
                325                 330                 335     


Leu Pro Ala Ser Val Gly Gly Ser Thr Arg Thr Pro Arg Pro Ala Ala 
            340                 345                 350         


Ala Gln Pro Ser Gln Lys Ile Thr Ala Thr Lys Ile Pro Lys Ser Leu 
        355                 360                 365             


Pro Thr Lys Pro Ser Ala Pro Ser Thr Ser Ile Val Pro Ile Lys Ser 
    370                 375                 380                 


Pro His Pro Thr Gln Lys Thr Ala Pro Ser Ser Phe Thr Lys Ser Ala 
385                 390                 395                 400 


Leu Pro Thr Gln Lys Gln Val Pro Pro Thr Ser Arg Pro Val Pro Ala 
                405                 410                 415     


Arg Val Ser Arg Pro Ala Glu Lys Pro Ile Gln Arg Asn Pro Gly Met 
            420                 425                 430         


Pro Arg Pro Pro Pro Pro Ser Thr Arg Pro Leu Pro Pro Thr Thr Ser 
        435                 440                 445             


Ser Ser Lys Lys Pro Ile Pro Thr Leu Ala Arg Thr Glu Ala Lys Ile 
    450                 455                 460                 


Thr Ser His Ala Ser Lys Pro Ala Ser Ala Arg Thr Ser Thr His Lys 
465                 470                 475                 480 


Pro Pro Pro Phe Thr Ala Leu Ser Ser Ser Pro Ala Pro Thr Pro Gly 
                485                 490                 495     


Ser Thr Arg Ser Thr Arg Pro Pro Ala Thr Met Val Pro Pro Thr Ser 
            500                 505                 510         


Gly Thr Ser Thr Pro Arg Thr Ala Pro Ala Val Pro Thr Pro Gly Ser 
        515                 520                 525             


Ala Pro Thr Gly Ser Lys Lys Pro Ile Gly Ser Glu Ala Ser Lys Lys 
    530                 535                 540                 


Ala Gly Pro Lys Ser Ser Pro Arg Lys Pro Val Pro Leu Arg Pro Gly 
545                 550                 555                 560 


Lys Ala Ala Arg Asp Val Pro Leu Ser Asp Leu Thr Thr Arg Pro Ser 
                565                 570                 575     


Pro Arg Gln Pro Gln Pro Ser Gln Gln Thr Thr Pro Ala Leu Val Leu 
            580                 585                 590         


Ala Pro Ala Gln Phe Leu Ser Ser Ser Pro Arg Pro Thr Ser Ser Gly 
        595                 600                 605             


Tyr Ser Ile Phe His Leu Ala Gly Ser Thr Pro Phe Pro Leu Leu Met 
    610                 615                 620                 


Gly Pro Pro Gly Pro Lys Gly Asp Cys Gly Leu Pro Gly Pro Pro Gly 
625                 630                 635                 640 


Leu Pro Gly Leu Pro Gly Ile Pro Gly Ala Arg Gly Pro Arg Gly Pro 
                645                 650                 655     


Pro Gly Pro Tyr Gly Asn Pro Gly Leu Pro Gly Pro Pro Gly Ala Lys 
            660                 665                 670         


Gly Gln Lys Gly Asp Pro Gly Leu Ser Pro Gly Lys Ala His Asp Gly 
        675                 680                 685             


Ala Lys Gly Asp Met Gly Leu Pro Gly Leu Ser Gly Asn Pro Gly Pro 
    690                 695                 700                 


Pro Gly Arg Lys Gly His Lys Gly Tyr Pro Gly Pro Ala Gly His Pro 
705                 710                 715                 720 


Gly Glu Gln Gly Gln Pro Gly Pro Glu Gly Ser Pro Gly Ala Lys Gly 
                725                 730                 735     


Tyr Pro Gly Arg Gln Gly Leu Pro Gly Pro Val Gly Asp Pro Gly Pro 
            740                 745                 750         


Lys Gly Ser Arg Gly Tyr Ile Gly Leu Pro Gly Leu Phe Gly Leu Pro 
        755                 760                 765             


Gly Ser Asp Gly Glu Arg Gly Leu Pro Gly Val Pro Gly Lys Arg Gly 
    770                 775                 780                 


Lys Met Gly Met Pro Gly Phe Pro Gly Val Phe Gly Glu Arg Gly Pro 
785                 790                 795                 800 


Pro Gly Leu Asp Gly Asn Pro Gly Glu Leu Gly Leu Pro Gly Pro Pro 
                805                 810                 815     


Gly Val Pro Gly Leu Ile Gly Asp Leu Gly Val Leu Gly Pro Ile Gly 
            820                 825                 830         


Tyr Pro Gly Pro Lys Gly Met Lys Gly Leu Met Gly Ser Val Gly Glu 
        835                 840                 845             


Pro Gly Leu Lys Gly Asp Lys Gly Glu Gln Gly Val Pro Gly Val Ser 
    850                 855                 860                 


Gly Asp Pro Gly Phe Gln Gly Asp Lys Gly Ser Gln Gly Leu Pro Gly 
865                 870                 875                 880 


Phe Pro Gly Ala Arg Gly Lys Pro Gly Pro Leu Gly Lys Val Gly Asp 
                885                 890                 895     


Lys Gly Ser Ile Gly Phe Pro Gly Pro Pro Gly Pro Glu Gly Phe Pro 
            900                 905                 910         


Gly Asp Ile Gly Pro Pro Gly Asp Asn Gly Pro Glu Gly Met Lys Gly 
        915                 920                 925             


Lys Pro Gly Ala Arg Gly Leu Pro Gly Pro Arg Gly Gln Leu Gly Pro 
    930                 935                 940                 


Glu Gly Asp Glu Gly Pro Met Gly Pro Pro Gly Ala Pro Gly Leu Glu 
945                 950                 955                 960 


Gly Gln Pro Gly Arg Lys Gly Phe Pro Gly Arg Pro Gly Leu Asp Gly 
                965                 970                 975     


Val Lys Gly Glu Pro Gly Asp Pro Gly Arg Pro Gly Pro Val Gly Glu 
            980                 985                 990         


Gln Gly Phe Met Gly Phe Ile Gly  Leu Val Gly Glu Pro  Gly Ile Val 
        995                 1000                 1005             


Gly Glu  Lys Gly Asp Arg Gly  Met Met Gly Pro Pro  Gly Val Pro 
    1010                 1015                 1020             


Gly Pro  Lys Gly Ser Met Gly  His Pro Gly Met Pro  Gly Gly Met 
    1025                 1030                 1035             


Gly Thr  Pro Gly Glu Pro Gly  Pro Gln Gly Pro Pro  Gly Ser Arg 
    1040                 1045                 1050             


Gly Pro  Pro Gly Met Arg Gly  Ala Lys Gly Arg Arg  Gly Pro Arg 
    1055                 1060                 1065             


Gly Pro  Asp Gly Pro Ala Gly  Glu Gln Gly Ser Arg  Gly Leu Lys 
    1070                 1075                 1080             


Gly Pro  Pro Gly Pro Gln Gly  Arg Pro Gly Arg Pro  Gly Gln Gln 
    1085                 1090                 1095             


Gly Val  Ala Gly Glu Arg Gly  His Leu Gly Ser Arg  Gly Phe Pro 
    1100                 1105                 1110             


Gly Ile  Pro Gly Pro Ser Gly  Pro Pro Gly Thr Lys  Gly Leu Pro 
    1115                 1120                 1125             


Gly Glu  Pro Gly Pro Gln Gly  Pro Gln Gly Pro Ile  Gly Pro Pro 
    1130                 1135                 1140             


Gly Glu  Met Gly Pro Lys Gly  Pro Pro Gly Ala Val  Gly Glu Pro 
    1145                 1150                 1155             


Gly Leu  Pro Gly Glu Ala Gly  Met Lys Gly Asp Leu  Gly Pro Leu 
    1160                 1165                 1170             


Gly Thr  Pro Gly Glu Gln Gly  Leu Ile Gly Gln Arg  Gly Glu Pro 
    1175                 1180                 1185             


Gly Leu  Glu Gly Asp Ser Gly  Pro Met Gly Pro Asp  Gly Leu Lys 
    1190                 1195                 1200             


Gly Asp  Arg Gly Asp Pro Gly  Pro Asp Gly Glu His  Gly Glu Lys 
    1205                 1210                 1215             


Gly Gln  Glu Gly Leu Met Gly  Glu Asp Gly Pro Pro  Gly Pro Pro 
    1220                 1225                 1230             


Gly Val  Thr Gly Val Arg Gly  Pro Glu Gly Lys Ser  Gly Lys Gln 
    1235                 1240                 1245             


Gly Glu  Lys Gly Arg Thr Gly  Ala Lys Gly Ala Lys  Gly Tyr Gln 
    1250                 1255                 1260             


Gly Gln  Leu Gly Glu Met Gly  Val Pro Gly Asp Pro  Gly Pro Pro 
    1265                 1270                 1275             


Gly Thr  Pro Gly Pro Lys Gly  Ser Arg Gly Ser Leu  Gly Pro Thr 
    1280                 1285                 1290             


Gly Ala  Pro Gly Arg Met Gly  Ala Gln Gly Glu Pro  Gly Leu Ala 
    1295                 1300                 1305             


Gly Tyr  Asp Gly His Lys Gly  Ile Val Gly Pro Leu  Gly Pro Pro 
    1310                 1315                 1320             


Gly Pro  Lys Gly Glu Lys Gly  Glu Gln Gly Glu Asp  Gly Lys Ala 
    1325                 1330                 1335             


Glu Gly  Pro Pro Gly Pro Pro  Gly Asp Arg Gly Pro  Val Gly Asp 
    1340                 1345                 1350             


Arg Gly  Asp Arg Gly Glu Pro  Gly Asp Pro Gly Tyr  Pro Gly Gln 
    1355                 1360                 1365             


Glu Gly  Val Gln Gly Leu Arg  Gly Lys Pro Gly Gln  Gln Gly Gln 
    1370                 1375                 1380             


Pro Gly  His Pro Gly Pro Arg  Gly Trp Pro Gly Pro  Lys Gly Ser 
    1385                 1390                 1395             


Lys Gly  Ala Glu Gly Pro Lys  Gly Lys Gln Gly Lys  Ala Gly Ala 
    1400                 1405                 1410             


Pro Gly  Arg Arg Gly Val Gln  Gly Leu Gln Gly Leu  Pro Gly Pro 
    1415                 1420                 1425             


Arg Gly  Val Val Gly Arg Gln  Gly Leu Glu Gly Ile  Ala Gly Pro 
    1430                 1435                 1440             


Asp Gly  Leu Pro Gly Arg Asp  Gly Gln Ala Gly Gln  Gln Gly Glu 
    1445                 1450                 1455             


Gln Gly  Asp Asp Gly Asp Pro  Gly Pro Met Gly Pro  Ala Gly Lys 
    1460                 1465                 1470             


Arg Gly  Asn Pro Gly Val Ala  Gly Leu Pro Gly Ala  Gln Gly Pro 
    1475                 1480                 1485             


Pro Gly  Phe Lys Gly Glu Ser  Gly Leu Pro Gly Gln  Leu Gly Pro 
    1490                 1495                 1500             


Pro Gly  Lys Arg Gly Thr Glu  Gly Arg Thr Gly Leu  Pro Gly Asn 
    1505                 1510                 1515             


Gln Gly  Glu Pro Gly Ser Lys  Gly Gln Pro Gly Asp  Ser Gly Glu 
    1520                 1525                 1530             


Met Gly  Phe Pro Gly Met Ala  Gly Leu Phe Gly Pro  Lys Gly Pro 
    1535                 1540                 1545             


Pro Gly  Asp Ile Gly Phe Lys  Gly Ile Gln Gly Pro  Arg Gly Pro 
    1550                 1555                 1560             


Pro Gly  Leu Met Gly Lys Glu  Gly Ile Val Gly Pro  Leu Gly Ile 
    1565                 1570                 1575             


Leu Gly  Pro Ser Gly Leu Pro  Gly Pro Lys Gly Asp  Lys Gly Ser 
    1580                 1585                 1590             


Arg Gly  Asp Trp Gly Leu Gln  Gly Pro Arg Gly Pro  Pro Gly Pro 
    1595                 1600                 1605             


Arg Gly  Arg Pro Gly Pro Pro  Gly Pro Pro Gly Gly  Pro Ile Gln 
    1610                 1615                 1620             


Leu Gln  Gln Asp Asp Leu Gly  Ala Ala Phe Gln Thr  Trp Met Asp 
    1625                 1630                 1635             


Thr Ser  Gly Ala Leu Arg Pro  Glu Ser Tyr Ser Tyr  Pro Asp Arg 
    1640                 1645                 1650             


Leu Val  Leu Asp Gln Gly Gly  Glu Ile Phe Lys Thr  Leu His Tyr 
    1655                 1660                 1665             


Leu Ser  Asn Leu Ile Gln Ser  Ile Lys Thr Pro Leu  Gly Thr Lys 
    1670                 1675                 1680             


Glu Asn  Pro Ala Arg Val Cys  Arg Asp Leu Met Asp  Cys Glu Gln 
    1685                 1690                 1695             


Lys Met  Val Asp Gly Thr Tyr  Trp Val Asp Pro Asn  Leu Gly Cys 
    1700                 1705                 1710             


Ser Ser  Asp Thr Ile Glu Val  Ser Cys Asn Phe Thr  His Gly Gly 
    1715                 1720                 1725             


Gln Thr  Cys Leu Lys Pro Ile  Thr Ala Ser Lys Val  Glu Phe Ala 
    1730                 1735                 1740             


Ile Ser  Arg Val Gln Met Asn  Phe Leu His Leu Leu  Ser Ser Glu 
    1745                 1750                 1755             


Val Thr  Gln His Ile Thr Ile  His Cys Leu Asn Met  Thr Val Trp 
    1760                 1765                 1770             


Gln Glu  Gly Thr Gly Gln Thr  Pro Ala Lys Gln Ala  Val Arg Phe 
    1775                 1780                 1785             


Arg Ala  Trp Asn Gly Gln Ile  Phe Glu Ala Gly Gly  Gln Phe Arg 
    1790                 1795                 1800             


Pro Glu  Val Ser Met Asp Gly  Cys Lys Val Gln Asp  Gly Arg Trp 
    1805                 1810                 1815             


His Gln  Thr Leu Phe Thr Phe  Arg Thr Gln Asp Pro  Gln Gln Leu 
    1820                 1825                 1830             


Pro Ile  Ile Ser Val Asp Asn  Leu Pro Pro Ala Ser  Ser Gly Lys 
    1835                 1840                 1845             


Gln Tyr  Arg Leu Glu Val Gly  Pro Ala Cys Phe Leu  
    1850                 1855                 1860 


<210>  3279
<211>  485
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3279

Xaa Ala Ala Gln Pro Ser Gln Lys Ile Thr Ala Thr Lys Ile Pro Lys 
1               5                   10                  15      


Ser Leu Pro Thr Lys Pro Ser Ala Pro Ser Thr Ser Ile Val Pro Ile 
            20                  25                  30          


Lys Ser Pro His Pro Thr Gln Lys Thr Ala Pro Ser Ser Phe Thr Lys 
        35                  40                  45              


Ser Ala Leu Pro Thr Gln Lys Gln Val Pro Pro Thr Ser Arg Pro Val 
    50                  55                  60                  


Pro Ala Arg Val Ser Arg Pro Ala Glu Lys Pro Ile Gln Arg Asn Pro 
65                  70                  75                  80  


Gly Met Pro Arg Pro Pro Pro Pro Ser Thr Arg Pro Leu Pro Pro Thr 
                85                  90                  95      


Thr Ser Ser Ser Lys Lys Pro Ile Pro Thr Leu Ala Arg Thr Glu Ala 
            100                 105                 110         


Lys Ile Thr Ser His Ala Ser Lys Pro Ala Ser Ala Arg Thr Ser Thr 
        115                 120                 125             


His Lys Pro Pro Pro Phe Thr Ala Leu Ser Ser Ser Pro Ala Pro Thr 
    130                 135                 140                 


Pro Gly Ser Thr Arg Ser Thr Arg Pro Pro Ala Thr Met Val Pro Pro 
145                 150                 155                 160 


Thr Ser Gly Thr Ser Thr Pro Arg Thr Ala Pro Ala Val Pro Thr Pro 
                165                 170                 175     


Gly Ser Ala Pro Thr Gly Ser Lys Lys Pro Ile Gly Ser Glu Ala Ser 
            180                 185                 190         


Lys Lys Ala Gly Pro Lys Ser Ser Pro Arg Lys Pro Val Pro Leu Arg 
        195                 200                 205             


Pro Gly Lys Ala Ala Arg Asp Val Pro Leu Ser Asp Leu Thr Thr Arg 
    210                 215                 220                 


Pro Ser Pro Arg Gln Pro Gln Pro Ser Gln Gln Thr Thr Pro Ala Leu 
225                 230                 235                 240 


Val Leu Ala Pro Ala Gln Phe Leu Ser Ser Ser Pro Arg Pro Thr Ser 
                245                 250                 255     


Ser Gly Tyr Ser Ile Phe His Leu Ala Gly Ser Thr Pro Phe Pro Leu 
            260                 265                 270         


Leu Met Gly Pro Pro Gly Pro Lys Gly Asp Cys Gly Leu Pro Gly Pro 
        275                 280                 285             


Pro Gly Leu Pro Gly Leu Pro Gly Ile Pro Gly Ala Arg Gly Pro Arg 
    290                 295                 300                 


Gly Pro Pro Gly Pro Tyr Gly Asn Pro Gly Leu Pro Gly Pro Pro Gly 
305                 310                 315                 320 


Ala Lys Gly Asp Met Gly Leu Pro Gly Leu Ser Gly Asn Pro Gly Pro 
                325                 330                 335     


Pro Gly Arg Lys Gly His Lys Gly Tyr Pro Gly Pro Ala Gly His Pro 
            340                 345                 350         


Gly Glu Gln Gly Gln Pro Gly Pro Glu Gly Ser Pro Gly Ala Lys Gly 
        355                 360                 365             


Tyr Pro Gly Arg Gln Gly Leu Pro Gly Pro Val Gly Asp Pro Gly Pro 
    370                 375                 380                 


Lys Gly Ser Arg Gly Tyr Ile Gly Leu Pro Gly Leu Phe Gly Leu Pro 
385                 390                 395                 400 


Gly Ser Asp Gly Glu Arg Gly Leu Pro Gly Val Pro Gly Lys Arg Gly 
                405                 410                 415     


Lys Met Gly Met Pro Gly Phe Pro Gly Val Phe Gly Glu Arg Gly Pro 
            420                 425                 430         


Pro Gly Leu Asp Gly Asn Pro Gly Glu Leu Gly Leu Pro Gly Pro Pro 
        435                 440                 445             


Gly Val Pro Gly Leu Ile Gly Asp Leu Gly Val Leu Gly Pro Ile Gly 
    450                 455                 460                 


Tyr Pro Gly Pro Lys Gly Met Lys Gly Leu Met Gly Ser Val Gly Glu 
465                 470                 475                 480 


Pro Gly Leu Lys Gly 
                485 


<210>  3280
<211>  80
<212>  PRT
<213>  Homo Sapiens

<400>  3280

Ala Thr Thr Ser Ser Glu Ala Thr Thr Thr Pro Arg Pro Leu Leu Ser 
1               5                   10                  15      


Thr Pro Val Asp Gly Ala Glu Asp Pro Arg Cys Leu Glu Ala Leu Lys 
            20                  25                  30          


Pro Gly Asn Cys Gly Glu Tyr Val Val Arg Trp Tyr Tyr Asp Lys Gln 
        35                  40                  45              


Val Asn Ser Cys Ala Arg Phe Trp Phe Ser Gly Cys Asn Gly Ser Gly 
    50                  55                  60                  


Asn Arg Phe Asn Ser Glu Lys Glu Cys Gln Glu Thr Cys Ile Gln Gly 
65                  70                  75                  80  


<210>  3281
<211>  142
<212>  PRT
<213>  Homo Sapiens

<400>  3281

Phe Asp Ser Tyr Leu Val Gln Ile Phe Gly Ser Ser Ser Pro Gln Pro 
1               5                   10                  15      


Gly Phe Gly Met Ser Gly Glu Glu Leu Ser Glu Ser Thr Pro Glu Pro 
            20                  25                  30          


Gln Lys Glu Ile Ser Glu Ser Leu Ser Val Thr Arg Asp Gln Asp Glu 
        35                  40                  45              


Asp Asp Lys Ala Pro Glu Pro Thr Trp Ala Asp Asp Leu Pro Ala Thr 
    50                  55                  60                  


Thr Ser Ser Glu Ala Thr Thr Thr Pro Arg Pro Leu Leu Ser Thr Pro 
65                  70                  75                  80  


Val Asp Gly Ala Glu Asp Pro Arg Cys Leu Glu Ala Leu Lys Pro Gly 
                85                  90                  95      


Asn Cys Gly Glu Tyr Val Val Arg Trp Tyr Tyr Asp Lys Gln Val Asn 
            100                 105                 110         


Ser Cys Ala Arg Phe Trp Phe Ser Gly Cys Asn Gly Ser Gly Asn Arg 
        115                 120                 125             


Phe Asn Ser Glu Lys Glu Cys Gln Glu Thr Cys Ile Gln Gly 
    130                 135                 140         


<210>  3282
<211>  130
<212>  PRT
<213>  Homo Sapiens

<400>  3282

Gly Met Pro Gly Thr Ser Ile Pro Gly Pro Pro Gly Pro Lys Gly Asp 
1               5                   10                  15      


Arg Gly Gly Pro Gly Ile Pro Gly Phe Lys Gly Glu Pro Gly Leu Ser 
            20                  25                  30          


Ile Arg Gly Pro Lys Gly Val Gln Gly Pro Arg Gly Pro Val Gly Ala 
        35                  40                  45              


Pro Gly Leu Lys Gly Asp Gly Tyr Pro Gly Val Pro Gly Pro Arg Gly 
    50                  55                  60                  


Leu Pro Gly Pro Pro Gly Pro Met Gly Leu Arg Gly Val Gly Asp Thr 
65                  70                  75                  80  


Gly Ala Lys Thr Leu Asn Thr Ser His Gly Leu Glu Asp Pro Ser Cys 
                85                  90                  95      


Pro Asp Cys Ser Phe Cys His Phe Ser Leu Ala Ala Asp Ile Gln Pro 
            100                 105                 110         


Lys Trp Pro Ala Leu Leu Gln Leu Ile Pro Ala Ser Gly Thr Arg Gln 
        115                 120                 125             


Asp Gly 
    130 


<210>  3283
<211>  67
<212>  PRT
<213>  Homo Sapiens

<400>  3283

Lys Gly Asn Pro Gly Asn Ala Gln Lys Gly Glu Ala Gly Glu Arg Gly 
1               5                   10                  15      


Pro Gly Gly Ile Pro Gly Tyr Lys Gly Asp Lys Gln Tyr Ser Arg Glu 
            20                  25                  30          


Asp Arg Glu Val Glu His Asn Asn Glu Lys Tyr Val Ala Cys Leu Leu 
        35                  40                  45              


Pro Ser Pro Ala Leu Leu Gln Gln Ser Ser Leu Thr His His Gly Thr 
    50                  55                  60                  


Cys Ser His 
65          


<210>  3284
<211>  1125
<212>  PRT
<213>  Homo Sapiens

<400>  3284

Met Trp Asn Arg Tyr Phe Val Phe Tyr Leu Leu Leu Leu Ser Ala Phe 
1               5                   10                  15      


Thr Ser Gln Thr Val Ser Gly Gln Arg Lys Lys Gly Pro Lys Ser Asn 
            20                  25                  30          


Leu Leu Ala Arg Lys Ser Asp Val Gln Gly Ser Ile Cys Phe Ile Asp 
        35                  40                  45              


Ile Val Phe Ile Val Asp Ser Ser Glu Ser Ser Lys Ile Ala Leu Phe 
    50                  55                  60                  


Asp Lys Gln Lys Asp Phe Val Asp Ser Leu Ser Asp Lys Ile Phe Gln 
65                  70                  75                  80  


Leu Thr Pro Gly Arg Ser Leu Glu Tyr Asp Ile Lys Leu Ala Ala Leu 
                85                  90                  95      


Gln Phe Ser Ser Ser Val Gln Ile Asp Pro Pro Phe Ser Ser Trp Lys 
            100                 105                 110         


Asp Leu Gln Thr Phe Lys Gln Lys Val Lys Ser Met Asn Leu Ile Gly 
        115                 120                 125             


Gln Gly Thr Phe Ser Tyr Tyr Ala Ile Ser Asn Ala Thr Arg Leu Leu 
    130                 135                 140                 


Lys Arg Glu Gly Arg Lys Asp Gly Val Lys Val Val Leu Leu Met Thr 
145                 150                 155                 160 


Asp Gly Ile Asp His Pro Lys Asn Pro Asp Val Gln Ser Ile Ser Glu 
                165                 170                 175     


Asp Ala Arg Ile Ser Gly Ile Ser Phe Ile Thr Ile Ala Leu Ser Thr 
            180                 185                 190         


Val Val Asn Glu Ala Lys Leu Arg Leu Ile Ser Gly Asp Ser Ser Ser 
        195                 200                 205             


Glu Pro Thr Leu Leu Leu Ser Asp Pro Thr Leu Val Asp Lys Ile Gln 
    210                 215                 220                 


Asp Arg Leu Asp Ile Leu Phe Glu Lys Lys Cys Glu Arg Lys Ile Cys 
225                 230                 235                 240 


Glu Cys Glu Lys Gly Asp Pro Gly Asp Pro Gly Pro Pro Gly Thr His 
                245                 250                 255     


Gly Asn Pro Gly Ile Lys Gly Glu Arg Gly Pro Lys Gly Asn Pro Gly 
            260                 265                 270         


Asn Ala Gln Lys Gly Glu Ala Gly Glu Arg Gly Pro Gly Gly Ile Pro 
        275                 280                 285             


Gly Tyr Lys Gly Asp Lys Gly Glu Arg Gly Glu Cys Gly Lys Pro Gly 
    290                 295                 300                 


Ile Lys Gly Asp Lys Gly Ser Pro Gly Pro Tyr Gly Pro Lys Gly Pro 
305                 310                 315                 320 


Arg Gly Ile Gln Gly Ile Thr Gly Pro Pro Gly Asp Pro Gly Pro Lys 
                325                 330                 335     


Gly Phe Gln Gly Asn Lys Gly Glu Pro Gly Pro Pro Gly Pro Tyr Gly 
            340                 345                 350         


Ser Pro Gly Ala Pro Gly Ile Gly Gln Gln Gly Ile Lys Gly Glu Arg 
        355                 360                 365             


Gly Gln Glu Gly Arg Pro Gly Ala Pro Gly Pro Ile Gly Val Gly Glu 
    370                 375                 380                 


Pro Gly Gln Pro Gly Pro Arg Gly Pro Glu Gly Val Pro Gly Glu Arg 
385                 390                 395                 400 


Gly Leu Pro Gly Glu Gly Phe Pro Gly Pro Lys Gly Glu Lys Gly Ser 
                405                 410                 415     


Glu Gly Pro Thr Gly Pro Gln Gly Leu Gln Gly Leu Ser Ile Lys Gly 
            420                 425                 430         


Glu Lys Gly Asp Ile Gly Pro Val Gly Pro Gln Gly Pro Met Gly Ile 
        435                 440                 445             


Pro Gly Ile Gly Ser Gln Gly Glu Gln Gly Ile Gln Gly Pro Ile Gly 
    450                 455                 460                 


Pro Pro Gly Pro Gln Gly Pro Ala Gly Gln Gly Leu Pro Gly Ser Lys 
465                 470                 475                 480 


Gly Glu Val Gly Gln Met Gly Pro Thr Gly Pro Arg Gly Pro Val Gly 
                485                 490                 495     


Ile Gly Val Gln Gly Pro Lys Gly Glu Pro Gly Ser Ile Gly Leu Pro 
            500                 505                 510         


Gly Gln Pro Gly Val Pro Gly Glu Asp Gly Ala Ala Gly Lys Lys Gly 
        515                 520                 525             


Glu Ala Gly Leu Pro Gly Ala Arg Gly Pro Glu Gly Pro Pro Gly Lys 
    530                 535                 540                 


Gly Gln Pro Gly Pro Lys Gly Asp Glu Gly Lys Lys Gly Ser Lys Gly 
545                 550                 555                 560 


Asn Gln Gly Gln Arg Gly Leu Pro Gly Pro Glu Gly Pro Lys Gly Glu 
                565                 570                 575     


Pro Gly Ile Met Gly Pro Phe Gly Met Pro Gly Thr Ser Ile Pro Gly 
            580                 585                 590         


Pro Pro Gly Pro Lys Gly Asp Arg Gly Gly Pro Gly Ile Pro Gly Phe 
        595                 600                 605             


Lys Gly Glu Pro Gly Leu Ser Ile Arg Gly Pro Lys Gly Val Gln Gly 
    610                 615                 620                 


Pro Arg Gly Pro Val Gly Ala Pro Gly Leu Lys Gly Asp Gly Tyr Pro 
625                 630                 635                 640 


Gly Val Pro Gly Pro Arg Gly Leu Pro Gly Pro Pro Gly Pro Met Gly 
                645                 650                 655     


Leu Arg Gly Val Gly Asp Thr Gly Ala Lys Gly Glu Pro Gly Val Arg 
            660                 665                 670         


Gly Pro Pro Gly Pro Ser Gly Pro Arg Gly Val Gly Thr Gln Gly Pro 
        675                 680                 685             


Lys Gly Asp Thr Gly Gln Lys Gly Leu Pro Gly Pro Pro Gly Pro Pro 
    690                 695                 700                 


Gly Tyr Gly Ser Gln Gly Ile Lys Gly Glu Gln Gly Pro Gln Gly Phe 
705                 710                 715                 720 


Pro Gly Pro Lys Gly Thr Met Gly His Gly Leu Pro Gly Gln Lys Gly 
                725                 730                 735     


Glu His Gly Glu Arg Gly Asp Val Gly Lys Lys Gly Asp Lys Gly Glu 
            740                 745                 750         


Ile Gly Glu Pro Gly Ser Pro Gly Lys Gln Gly Leu Gln Gly Pro Lys 
        755                 760                 765             


Gly Asp Leu Gly Leu Thr Lys Glu Glu Ile Ile Lys Leu Ile Thr Glu 
    770                 775                 780                 


Ile Cys Gly Cys Gly Pro Lys Cys Lys Glu Thr Pro Leu Glu Leu Val 
785                 790                 795                 800 


Phe Val Ile Asp Ser Ser Glu Ser Val Gly Pro Glu Asn Phe Gln Ile 
                805                 810                 815     


Ile Lys Asn Phe Val Lys Thr Met Ala Asp Arg Val Ala Leu Asp Leu 
            820                 825                 830         


Ala Thr Ala Arg Ile Gly Ile Ile Asn Tyr Ser His Lys Val Glu Lys 
        835                 840                 845             


Val Ala Asn Leu Lys Gln Phe Ser Ser Lys Asp Asp Phe Lys Leu Ala 
    850                 855                 860                 


Val Asp Asn Met Gln Tyr Leu Gly Glu Gly Thr Tyr Thr Ala Thr Ala 
865                 870                 875                 880 


Leu Gln Ala Ala Asn Asp Met Phe Glu Asp Ala Arg Pro Gly Val Lys 
                885                 890                 895     


Lys Val Ala Leu Val Ile Thr Asp Gly Gln Thr Asp Ser Arg Asp Lys 
            900                 905                 910         


Glu Lys Leu Thr Glu Val Val Lys Asn Ala Ser Asp Thr Asn Val Glu 
        915                 920                 925             


Ile Phe Val Ile Gly Val Val Lys Lys Asn Asp Pro Asn Phe Glu Ile 
    930                 935                 940                 


Phe His Lys Glu Met Asn Leu Ile Ala Thr Asp Pro Glu His Val Tyr 
945                 950                 955                 960 


Gln Phe Asp Asp Phe Phe Thr Leu Gln Asp Thr Leu Lys Gln Lys Leu 
                965                 970                 975     


Phe Gln Lys Ile Cys Glu Asp Phe Asp Ser Tyr Leu Val Gln Ile Phe 
            980                 985                 990         


Gly Ser Ser Ser Pro Gln Pro Gly  Phe Gly Met Ser Gly  Glu Glu Leu 
        995                 1000                 1005             


Ser Glu  Ser Thr Pro Glu Pro  Gln Lys Glu Ile Ser  Glu Ser Leu 
    1010                 1015                 1020             


Ser Val  Thr Arg Asp Gln Asp  Glu Asp Asp Lys Ala  Pro Glu Pro 
    1025                 1030                 1035             


Thr Trp  Ala Asp Asp Leu Pro  Ala Thr Thr Ser Ser  Glu Ala Thr 
    1040                 1045                 1050             


Thr Thr  Pro Arg Pro Leu Leu  Ser Thr Pro Val Asp  Gly Ala Glu 
    1055                 1060                 1065             


Asp Pro  Arg Cys Leu Glu Ala  Leu Lys Pro Gly Asn  Cys Gly Glu 
    1070                 1075                 1080             


Tyr Val  Val Arg Trp Tyr Tyr  Asp Lys Gln Val Asn  Ser Cys Ala 
    1085                 1090                 1095             


Arg Phe  Trp Phe Ser Gly Cys  Asn Gly Ser Gly Asn  Arg Phe Asn 
    1100                 1105                 1110             


Ser Glu  Lys Glu Cys Gln Glu  Thr Cys Ile Gln Gly  
    1115                 1120                 1125 


<210>  3285
<211>  1487
<212>  PRT
<213>  Homo Sapiens

<400>  3285

Met Ile Arg Leu Gly Ala Pro Gln Thr Leu Val Leu Leu Thr Leu Leu 
1               5                   10                  15      


Val Ala Ala Val Leu Arg Cys Gln Gly Gln Asp Val Gln Glu Ala Gly 
            20                  25                  30          


Ser Cys Val Gln Asp Gly Gln Arg Tyr Asn Asp Lys Asp Val Trp Lys 
        35                  40                  45              


Pro Glu Pro Cys Arg Ile Cys Val Cys Asp Thr Gly Thr Val Leu Cys 
    50                  55                  60                  


Asp Asp Ile Ile Cys Glu Asp Val Lys Asp Cys Leu Ser Pro Glu Ile 
65                  70                  75                  80  


Pro Phe Gly Glu Cys Cys Pro Ile Cys Pro Thr Asp Leu Ala Thr Ala 
                85                  90                  95      


Ser Gly Gln Pro Gly Pro Lys Gly Gln Lys Gly Glu Pro Gly Asp Ile 
            100                 105                 110         


Lys Asp Ile Val Gly Pro Lys Gly Pro Pro Gly Pro Gln Gly Pro Ala 
        115                 120                 125             


Gly Glu Gln Gly Pro Arg Gly Asp Arg Gly Asp Lys Gly Glu Lys Gly 
    130                 135                 140                 


Ala Pro Gly Pro Arg Gly Arg Asp Gly Glu Pro Gly Thr Pro Gly Asn 
145                 150                 155                 160 


Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly 
                165                 170                 175     


Gly Asn Phe Ala Ala Gln Met Ala Gly Gly Phe Asp Glu Lys Ala Gly 
            180                 185                 190         


Gly Ala Gln Leu Gly Val Met Gln Gly Pro Met Gly Pro Met Gly Pro 
        195                 200                 205             


Arg Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro Gln Gly Phe Gln 
    210                 215                 220                 


Gly Asn Pro Gly Glu Pro Gly Glu Pro Gly Val Ser Gly Pro Met Gly 
225                 230                 235                 240 


Pro Arg Gly Pro Pro Gly Pro Pro Gly Lys Pro Gly Asp Asp Gly Glu 
                245                 250                 255     


Ala Gly Lys Pro Gly Lys Ala Gly Glu Arg Gly Pro Pro Gly Pro Gln 
            260                 265                 270         


Gly Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Pro Gly Val Lys Gly 
        275                 280                 285             


His Arg Gly Tyr Pro Gly Leu Asp Gly Ala Lys Gly Glu Ala Gly Ala 
    290                 295                 300                 


Pro Gly Val Lys Gly Glu Ser Gly Ser Pro Gly Glu Asn Gly Ser Pro 
305                 310                 315                 320 


Gly Pro Met Gly Pro Arg Gly Leu Pro Gly Glu Arg Gly Arg Thr Gly 
                325                 330                 335     


Pro Ala Gly Ala Ala Gly Ala Arg Gly Asn Asp Gly Gln Pro Gly Pro 
            340                 345                 350         


Ala Gly Pro Pro Gly Pro Val Gly Pro Ala Gly Gly Pro Gly Phe Pro 
        355                 360                 365             


Gly Ala Pro Gly Ala Lys Gly Glu Ala Gly Pro Thr Gly Ala Arg Gly 
    370                 375                 380                 


Pro Glu Gly Ala Gln Gly Pro Arg Gly Glu Pro Gly Thr Pro Gly Ser 
385                 390                 395                 400 


Pro Gly Pro Ala Gly Ala Ser Gly Asn Pro Gly Thr Asp Gly Ile Pro 
                405                 410                 415     


Gly Ala Lys Gly Ser Ala Gly Ala Pro Gly Ile Ala Gly Ala Pro Gly 
            420                 425                 430         


Phe Pro Gly Pro Arg Gly Pro Pro Gly Pro Gln Gly Ala Thr Gly Pro 
        435                 440                 445             


Leu Gly Pro Lys Gly Gln Thr Gly Glu Pro Gly Ile Ala Gly Phe Lys 
    450                 455                 460                 


Gly Glu Gln Gly Pro Lys Gly Glu Pro Gly Pro Ala Gly Pro Gln Gly 
465                 470                 475                 480 


Ala Pro Gly Pro Ala Gly Glu Glu Gly Lys Arg Gly Ala Arg Gly Glu 
                485                 490                 495     


Pro Gly Gly Val Gly Pro Ile Gly Pro Pro Gly Glu Arg Gly Ala Pro 
            500                 505                 510         


Gly Asn Arg Gly Phe Pro Gly Gln Asp Gly Leu Ala Gly Pro Lys Gly 
        515                 520                 525             


Ala Pro Gly Glu Arg Gly Pro Ser Gly Leu Ala Gly Pro Lys Gly Ala 
    530                 535                 540                 


Asn Gly Asp Pro Gly Arg Pro Gly Glu Pro Gly Leu Pro Gly Ala Arg 
545                 550                 555                 560 


Gly Leu Thr Gly Arg Pro Gly Asp Ala Gly Pro Gln Gly Lys Val Gly 
                565                 570                 575     


Pro Ser Gly Ala Pro Gly Glu Asp Gly Arg Pro Gly Pro Pro Gly Pro 
            580                 585                 590         


Gln Gly Ala Arg Gly Gln Pro Gly Val Met Gly Phe Pro Gly Pro Lys 
        595                 600                 605             


Gly Ala Asn Gly Glu Pro Gly Lys Ala Gly Glu Lys Gly Leu Pro Gly 
    610                 615                 620                 


Ala Pro Gly Leu Arg Gly Leu Pro Gly Lys Asp Gly Glu Thr Gly Ala 
625                 630                 635                 640 


Ala Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly Glu Arg Gly Glu Gln 
                645                 650                 655     


Gly Ala Pro Gly Pro Ser Gly Phe Gln Gly Leu Pro Gly Pro Pro Gly 
            660                 665                 670         


Pro Pro Gly Glu Gly Gly Lys Pro Gly Asp Gln Gly Val Pro Gly Glu 
        675                 680                 685             


Ala Gly Ala Pro Gly Leu Val Gly Pro Arg Gly Glu Arg Gly Phe Pro 
    690                 695                 700                 


Gly Glu Arg Gly Ser Pro Gly Ala Gln Gly Leu Gln Gly Pro Arg Gly 
705                 710                 715                 720 


Leu Pro Gly Thr Pro Gly Thr Asp Gly Pro Lys Gly Ala Ser Gly Pro 
                725                 730                 735     


Ala Gly Pro Pro Gly Ala Gln Gly Pro Pro Gly Leu Gln Gly Met Pro 
            740                 745                 750         


Gly Glu Arg Gly Ala Ala Gly Ile Ala Gly Pro Lys Gly Asp Arg Gly 
        755                 760                 765             


Asp Val Gly Glu Lys Gly Pro Glu Gly Ala Pro Gly Lys Asp Gly Gly 
    770                 775                 780                 


Arg Gly Leu Thr Gly Pro Ile Gly Pro Pro Gly Pro Ala Gly Ala Asn 
785                 790                 795                 800 


Gly Glu Lys Gly Glu Val Gly Pro Pro Gly Pro Ala Gly Ser Ala Gly 
                805                 810                 815     


Ala Arg Gly Ala Pro Gly Glu Arg Gly Glu Thr Gly Pro Pro Gly Pro 
            820                 825                 830         


Ala Gly Phe Ala Gly Pro Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys 
        835                 840                 845             


Gly Glu Gln Gly Glu Ala Gly Gln Lys Gly Asp Ala Gly Ala Pro Gly 
    850                 855                 860                 


Pro Gln Gly Pro Ser Gly Ala Pro Gly Pro Gln Gly Pro Thr Gly Val 
865                 870                 875                 880 


Thr Gly Pro Lys Gly Ala Arg Gly Ala Gln Gly Pro Pro Gly Ala Thr 
                885                 890                 895     


Gly Phe Pro Gly Ala Ala Gly Arg Val Gly Pro Pro Gly Ser Asn Gly 
            900                 905                 910         


Asn Pro Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Lys Asp Gly Pro 
        915                 920                 925             


Lys Gly Ala Arg Gly Asp Ser Gly Pro Pro Gly Arg Ala Gly Glu Pro 
    930                 935                 940                 


Gly Leu Gln Gly Pro Ala Gly Pro Pro Gly Glu Lys Gly Glu Pro Gly 
945                 950                 955                 960 


Asp Asp Gly Pro Ser Gly Ala Glu Gly Pro Pro Gly Pro Gln Gly Leu 
                965                 970                 975     


Ala Gly Gln Arg Gly Ile Val Gly Leu Pro Gly Gln Arg Gly Glu Arg 
            980                 985                 990         


Gly Phe Pro Gly Leu Pro Gly Pro  Ser Gly Glu Pro Gly  Lys Gln Gly 
        995                 1000                 1005             


Ala Pro  Gly Ala Ser Gly Asp  Arg Gly Pro Pro Gly  Pro Val Gly 
    1010                 1015                 1020             


Pro Pro  Gly Leu Thr Gly Pro  Ala Gly Glu Pro Gly  Arg Glu Gly 
    1025                 1030                 1035             


Ser Pro  Gly Ala Asp Gly Pro  Pro Gly Arg Asp Gly  Ala Ala Gly 
    1040                 1045                 1050             


Val Lys  Gly Asp Arg Gly Glu  Thr Gly Ala Val Gly  Ala Pro Gly 
    1055                 1060                 1065             


Ala Pro  Gly Pro Pro Gly Ser  Pro Gly Pro Ala Gly  Pro Thr Gly 
    1070                 1075                 1080             


Lys Gln  Gly Asp Arg Gly Glu  Ala Gly Ala Gln Gly  Pro Met Gly 
    1085                 1090                 1095             


Pro Ser  Gly Pro Ala Gly Ala  Arg Gly Ile Gln Gly  Pro Gln Gly 
    1100                 1105                 1110             


Pro Arg  Gly Asp Lys Gly Glu  Ala Gly Glu Pro Gly  Glu Arg Gly 
    1115                 1120                 1125             


Leu Lys  Gly His Arg Gly Phe  Thr Gly Leu Gln Gly  Leu Pro Gly 
    1130                 1135                 1140             


Pro Pro  Gly Pro Ser Gly Asp  Gln Gly Ala Ser Gly  Pro Ala Gly 
    1145                 1150                 1155             


Pro Ser  Gly Pro Arg Gly Pro  Pro Gly Pro Val Gly  Pro Ser Gly 
    1160                 1165                 1170             


Lys Asp  Gly Ala Asn Gly Ile  Pro Gly Pro Ile Gly  Pro Pro Gly 
    1175                 1180                 1185             


Pro Arg  Gly Arg Ser Gly Glu  Thr Gly Pro Ala Gly  Pro Pro Gly 
    1190                 1195                 1200             


Asn Pro  Gly Pro Pro Gly Pro  Pro Gly Pro Pro Gly  Pro Gly Ile 
    1205                 1210                 1215             


Asp Met  Ser Ala Phe Ala Gly  Leu Gly Pro Arg Glu  Lys Gly Pro 
    1220                 1225                 1230             


Asp Pro  Leu Gln Tyr Met Arg  Ala Asp Gln Ala Ala  Gly Gly Leu 
    1235                 1240                 1245             


Arg Gln  His Asp Ala Glu Val  Asp Ala Thr Leu Lys  Ser Leu Asn 
    1250                 1255                 1260             


Asn Gln  Ile Glu Ser Ile Arg  Ser Pro Glu Gly Ser  Arg Lys Asn 
    1265                 1270                 1275             


Pro Ala  Arg Thr Cys Arg Asp  Leu Lys Leu Cys His  Pro Glu Trp 
    1280                 1285                 1290             


Lys Ser  Gly Asp Tyr Trp Ile  Asp Pro Asn Gln Gly  Cys Thr Leu 
    1295                 1300                 1305             


Asp Ala  Met Lys Val Phe Cys  Asn Met Glu Thr Gly  Glu Thr Cys 
    1310                 1315                 1320             


Val Tyr  Pro Asn Pro Ala Asn  Val Pro Lys Lys Asn  Trp Trp Ser 
    1325                 1330                 1335             


Ser Lys  Ser Lys Glu Lys Lys  His Ile Trp Phe Gly  Glu Thr Ile 
    1340                 1345                 1350             


Asn Gly  Gly Phe His Phe Ser  Tyr Gly Asp Asp Asn  Leu Ala Pro 
    1355                 1360                 1365             


Asn Thr  Ala Asn Val Gln Met  Thr Phe Leu Arg Leu  Leu Ser Thr 
    1370                 1375                 1380             


Glu Gly  Ser Gln Asn Ile Thr  Tyr His Cys Lys Asn  Ser Ile Ala 
    1385                 1390                 1395             


Tyr Leu  Asp Glu Ala Ala Gly  Asn Leu Lys Lys Ala  Leu Leu Ile 
    1400                 1405                 1410             


Gln Gly  Ser Asn Asp Val Glu  Ile Arg Ala Glu Gly  Asn Ser Arg 
    1415                 1420                 1425             


Phe Thr  Tyr Thr Ala Leu Lys  Asp Gly Cys Thr Lys  His Thr Gly 
    1430                 1435                 1440             


Lys Trp  Gly Lys Thr Val Ile  Glu Tyr Arg Ser Gln  Lys Thr Ser 
    1445                 1450                 1455             


Arg Leu  Pro Ile Ile Asp Ile  Ala Pro Met Asp Ile  Gly Gly Pro 
    1460                 1465                 1470             


Glu Gln  Glu Phe Gly Val Asp  Ile Gly Pro Val Cys  Phe Leu 
    1475                 1480                 1485         


<210>  3286
<211>  1418
<212>  PRT
<213>  Homo Sapiens

<400>  3286

Met Ile Arg Leu Gly Ala Pro Gln Thr Leu Val Leu Leu Thr Leu Leu 
1               5                   10                  15      


Val Ala Ala Val Leu Arg Cys Gln Gly Gln Asp Val Arg Gln Pro Gly 
            20                  25                  30          


Pro Lys Gly Gln Lys Gly Glu Pro Gly Asp Ile Lys Asp Ile Val Gly 
        35                  40                  45              


Pro Lys Gly Pro Pro Gly Pro Gln Gly Pro Ala Gly Glu Gln Gly Pro 
    50                  55                  60                  


Arg Gly Asp Arg Gly Asp Lys Gly Glu Lys Gly Ala Pro Gly Pro Arg 
65                  70                  75                  80  


Gly Arg Asp Gly Glu Pro Gly Thr Pro Gly Asn Pro Gly Pro Pro Gly 
                85                  90                  95      


Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala Ala 
            100                 105                 110         


Gln Met Ala Gly Gly Phe Asp Glu Lys Ala Gly Gly Ala Gln Leu Gly 
        115                 120                 125             


Val Met Gln Gly Pro Met Gly Pro Met Gly Pro Arg Gly Pro Pro Gly 
    130                 135                 140                 


Pro Ala Gly Ala Pro Gly Pro Gln Gly Phe Gln Gly Asn Pro Gly Glu 
145                 150                 155                 160 


Pro Gly Glu Pro Gly Val Ser Gly Pro Met Gly Pro Arg Gly Pro Pro 
                165                 170                 175     


Gly Pro Pro Gly Lys Pro Gly Asp Asp Gly Glu Ala Gly Lys Pro Gly 
            180                 185                 190         


Lys Ala Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly Ala Arg Gly Phe 
        195                 200                 205             


Pro Gly Thr Pro Gly Leu Pro Gly Val Lys Gly His Arg Gly Tyr Pro 
    210                 215                 220                 


Gly Leu Asp Gly Ala Lys Gly Glu Ala Gly Ala Pro Gly Val Lys Gly 
225                 230                 235                 240 


Glu Ser Gly Ser Pro Gly Glu Asn Gly Ser Pro Gly Pro Met Gly Pro 
                245                 250                 255     


Arg Gly Leu Pro Gly Glu Arg Gly Arg Thr Gly Pro Ala Gly Ala Ala 
            260                 265                 270         


Gly Ala Arg Gly Asn Asp Gly Gln Pro Gly Pro Ala Gly Pro Pro Gly 
        275                 280                 285             


Pro Val Gly Pro Ala Gly Gly Pro Gly Phe Pro Gly Ala Pro Gly Ala 
    290                 295                 300                 


Lys Gly Glu Ala Gly Pro Thr Gly Ala Arg Gly Pro Glu Gly Ala Gln 
305                 310                 315                 320 


Gly Pro Arg Gly Glu Pro Gly Thr Pro Gly Ser Pro Gly Pro Ala Gly 
                325                 330                 335     


Ala Ser Gly Asn Pro Gly Thr Asp Gly Ile Pro Gly Ala Lys Gly Ser 
            340                 345                 350         


Ala Gly Ala Pro Gly Ile Ala Gly Ala Pro Gly Phe Pro Gly Pro Arg 
        355                 360                 365             


Gly Pro Pro Gly Pro Gln Gly Ala Thr Gly Pro Leu Gly Pro Lys Gly 
    370                 375                 380                 


Gln Thr Gly Glu Pro Gly Ile Ala Gly Phe Lys Gly Glu Gln Gly Pro 
385                 390                 395                 400 


Lys Gly Glu Pro Gly Pro Ala Gly Pro Gln Gly Ala Pro Gly Pro Ala 
                405                 410                 415     


Gly Glu Glu Gly Lys Arg Gly Ala Arg Gly Glu Pro Gly Gly Val Gly 
            420                 425                 430         


Pro Ile Gly Pro Pro Gly Glu Arg Gly Ala Pro Gly Asn Arg Gly Phe 
        435                 440                 445             


Pro Gly Gln Asp Gly Leu Ala Gly Pro Lys Gly Ala Pro Gly Glu Arg 
    450                 455                 460                 


Gly Pro Ser Gly Leu Ala Gly Pro Lys Gly Ala Asn Gly Asp Pro Gly 
465                 470                 475                 480 


Arg Pro Gly Glu Pro Gly Leu Pro Gly Ala Arg Gly Leu Thr Gly Arg 
                485                 490                 495     


Pro Gly Asp Ala Gly Pro Gln Gly Lys Val Gly Pro Ser Gly Ala Pro 
            500                 505                 510         


Gly Glu Asp Gly Arg Pro Gly Pro Pro Gly Pro Gln Gly Ala Arg Gly 
        515                 520                 525             


Gln Pro Gly Val Met Gly Phe Pro Gly Pro Lys Gly Ala Asn Gly Glu 
    530                 535                 540                 


Pro Gly Lys Ala Gly Glu Lys Gly Leu Pro Gly Ala Pro Gly Leu Arg 
545                 550                 555                 560 


Gly Leu Pro Gly Lys Asp Gly Glu Thr Gly Ala Ala Gly Pro Pro Gly 
                565                 570                 575     


Pro Ala Gly Pro Ala Gly Glu Arg Gly Glu Gln Gly Ala Pro Gly Pro 
            580                 585                 590         


Ser Gly Phe Gln Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Glu Gly 
        595                 600                 605             


Gly Lys Pro Gly Asp Gln Gly Val Pro Gly Glu Ala Gly Ala Pro Gly 
    610                 615                 620                 


Leu Val Gly Pro Arg Gly Glu Arg Gly Phe Pro Gly Glu Arg Gly Ser 
625                 630                 635                 640 


Pro Gly Ala Gln Gly Leu Gln Gly Pro Arg Gly Leu Pro Gly Thr Pro 
                645                 650                 655     


Gly Thr Asp Gly Pro Lys Gly Ala Ser Gly Pro Ala Gly Pro Pro Gly 
            660                 665                 670         


Ala Gln Gly Pro Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Ala 
        675                 680                 685             


Ala Gly Ile Ala Gly Pro Lys Gly Asp Arg Gly Asp Val Gly Glu Lys 
    690                 695                 700                 


Gly Pro Glu Gly Ala Pro Gly Lys Asp Gly Gly Arg Gly Leu Thr Gly 
705                 710                 715                 720 


Pro Ile Gly Pro Pro Gly Pro Ala Gly Ala Asn Gly Glu Lys Gly Glu 
                725                 730                 735     


Val Gly Pro Pro Gly Pro Ala Gly Ser Ala Gly Ala Arg Gly Ala Pro 
            740                 745                 750         


Gly Glu Arg Gly Glu Thr Gly Pro Pro Gly Pro Ala Gly Phe Ala Gly 
        755                 760                 765             


Pro Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Glu Gln Gly Glu 
    770                 775                 780                 


Ala Gly Gln Lys Gly Asp Ala Gly Ala Pro Gly Pro Gln Gly Pro Ser 
785                 790                 795                 800 


Gly Ala Pro Gly Pro Gln Gly Pro Thr Gly Val Thr Gly Pro Lys Gly 
                805                 810                 815     


Ala Arg Gly Ala Gln Gly Pro Pro Gly Ala Thr Gly Phe Pro Gly Ala 
            820                 825                 830         


Ala Gly Arg Val Gly Pro Pro Gly Ser Asn Gly Asn Pro Gly Pro Pro 
        835                 840                 845             


Gly Pro Pro Gly Pro Ser Gly Lys Asp Gly Pro Lys Gly Ala Arg Gly 
    850                 855                 860                 


Asp Ser Gly Pro Pro Gly Arg Ala Gly Glu Pro Gly Leu Gln Gly Pro 
865                 870                 875                 880 


Ala Gly Pro Pro Gly Glu Lys Gly Glu Pro Gly Asp Asp Gly Pro Ser 
                885                 890                 895     


Gly Ala Glu Gly Pro Pro Gly Pro Gln Gly Leu Ala Gly Gln Arg Gly 
            900                 905                 910         


Ile Val Gly Leu Pro Gly Gln Arg Gly Glu Arg Gly Phe Pro Gly Leu 
        915                 920                 925             


Pro Gly Pro Ser Gly Glu Pro Gly Lys Gln Gly Ala Pro Gly Ala Ser 
    930                 935                 940                 


Gly Asp Arg Gly Pro Pro Gly Pro Val Gly Pro Pro Gly Leu Thr Gly 
945                 950                 955                 960 


Pro Ala Gly Glu Pro Gly Arg Glu Gly Ser Pro Gly Ala Asp Gly Pro 
                965                 970                 975     


Pro Gly Arg Asp Gly Ala Ala Gly Val Lys Gly Asp Arg Gly Glu Thr 
            980                 985                 990         


Gly Ala Val Gly Ala Pro Gly Ala  Pro Gly Pro Pro Gly  Ser Pro Gly 
        995                 1000                 1005             


Pro Ala  Gly Pro Thr Gly Lys  Gln Gly Asp Arg Gly  Glu Ala Gly 
    1010                 1015                 1020             


Ala Gln  Gly Pro Met Gly Pro  Ser Gly Pro Ala Gly  Ala Arg Gly 
    1025                 1030                 1035             


Ile Gln  Gly Pro Gln Gly Pro  Arg Gly Asp Lys Gly  Glu Ala Gly 
    1040                 1045                 1050             


Glu Pro  Gly Glu Arg Gly Leu  Lys Gly His Arg Gly  Phe Thr Gly 
    1055                 1060                 1065             


Leu Gln  Gly Leu Pro Gly Pro  Pro Gly Pro Ser Gly  Asp Gln Gly 
    1070                 1075                 1080             


Ala Ser  Gly Pro Ala Gly Pro  Ser Gly Pro Arg Gly  Pro Pro Gly 
    1085                 1090                 1095             


Pro Val  Gly Pro Ser Gly Lys  Asp Gly Ala Asn Gly  Ile Pro Gly 
    1100                 1105                 1110             


Pro Ile  Gly Pro Pro Gly Pro  Arg Gly Arg Ser Gly  Glu Thr Gly 
    1115                 1120                 1125             


Pro Ala  Gly Pro Pro Gly Asn  Pro Gly Pro Pro Gly  Pro Pro Gly 
    1130                 1135                 1140             


Pro Pro  Gly Pro Gly Ile Asp  Met Ser Ala Phe Ala  Gly Leu Gly 
    1145                 1150                 1155             


Pro Arg  Glu Lys Gly Pro Asp  Pro Leu Gln Tyr Met  Arg Ala Asp 
    1160                 1165                 1170             


Gln Ala  Ala Gly Gly Leu Arg  Gln His Asp Ala Glu  Val Asp Ala 
    1175                 1180                 1185             


Thr Leu  Lys Ser Leu Asn Asn  Gln Ile Glu Ser Ile  Arg Ser Pro 
    1190                 1195                 1200             


Glu Gly  Ser Arg Lys Asn Pro  Ala Arg Thr Cys Arg  Asp Leu Lys 
    1205                 1210                 1215             


Leu Cys  His Pro Glu Trp Lys  Ser Gly Asp Tyr Trp  Ile Asp Pro 
    1220                 1225                 1230             


Asn Gln  Gly Cys Thr Leu Asp  Ala Met Lys Val Phe  Cys Asn Met 
    1235                 1240                 1245             


Glu Thr  Gly Glu Thr Cys Val  Tyr Pro Asn Pro Ala  Asn Val Pro 
    1250                 1255                 1260             


Lys Lys  Asn Trp Trp Ser Ser  Lys Ser Lys Glu Lys  Lys His Ile 
    1265                 1270                 1275             


Trp Phe  Gly Glu Thr Ile Asn  Gly Gly Phe His Phe  Ser Tyr Gly 
    1280                 1285                 1290             


Asp Asp  Asn Leu Ala Pro Asn  Thr Ala Asn Val Gln  Met Thr Phe 
    1295                 1300                 1305             


Leu Arg  Leu Leu Ser Thr Glu  Gly Ser Gln Asn Ile  Thr Tyr His 
    1310                 1315                 1320             


Cys Lys  Asn Ser Ile Ala Tyr  Leu Asp Glu Ala Ala  Gly Asn Leu 
    1325                 1330                 1335             


Lys Lys  Ala Leu Leu Ile Gln  Gly Ser Asn Asp Val  Glu Ile Arg 
    1340                 1345                 1350             


Ala Glu  Gly Asn Ser Arg Phe  Thr Tyr Thr Ala Leu  Lys Asp Gly 
    1355                 1360                 1365             


Cys Thr  Lys His Thr Gly Lys  Trp Gly Lys Thr Val  Ile Glu Tyr 
    1370                 1375                 1380             


Arg Ser  Gln Lys Thr Ser Arg  Leu Pro Ile Ile Asp  Ile Ala Pro 
    1385                 1390                 1395             


Met Asp  Ile Gly Gly Pro Glu  Gln Glu Phe Gly Val  Asp Ile Gly 
    1400                 1405                 1410             


Pro Val  Cys Phe Leu 
    1415             


<210>  3287
<211>  1466
<212>  PRT
<213>  Homo Sapiens

<400>  3287

Met Met Ser Phe Val Gln Lys Gly Ser Trp Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


His Pro Thr Ile Ile Leu Ala Gln Gln Glu Ala Val Glu Gly Gly Cys 
            20                  25                  30          


Ser His Leu Gly Gln Ser Tyr Ala Asp Arg Asp Val Trp Lys Pro Glu 
        35                  40                  45              


Pro Cys Gln Ile Cys Val Cys Asp Ser Gly Ser Val Leu Cys Asp Asp 
    50                  55                  60                  


Ile Ile Cys Asp Asp Gln Glu Leu Asp Cys Pro Asn Pro Glu Ile Pro 
65                  70                  75                  80  


Phe Gly Glu Cys Cys Ala Val Cys Pro Gln Pro Pro Thr Ala Pro Thr 
                85                  90                  95      


Arg Pro Pro Asn Gly Gln Gly Pro Gln Gly Pro Lys Gly Asp Pro Gly 
            100                 105                 110         


Pro Pro Gly Ile Pro Gly Arg Asn Gly Asp Pro Gly Ile Pro Gly Gln 
        115                 120                 125             


Pro Gly Ser Pro Gly Ser Pro Gly Pro Pro Gly Ile Cys Glu Ser Cys 
    130                 135                 140                 


Pro Thr Gly Pro Gln Asn Tyr Ser Pro Gln Tyr Asp Ser Tyr Asp Val 
145                 150                 155                 160 


Lys Ser Gly Val Ala Val Gly Gly Leu Ala Gly Tyr Pro Gly Pro Ala 
                165                 170                 175     


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Thr Ser Gly His Pro Gly 
            180                 185                 190         


Ser Pro Gly Ser Pro Gly Tyr Gln Gly Pro Pro Gly Glu Pro Gly Gln 
        195                 200                 205             


Ala Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly Ala Ile Gly Pro Ser 
    210                 215                 220                 


Gly Pro Ala Gly Lys Asp Gly Glu Ser Gly Arg Pro Gly Arg Pro Gly 
225                 230                 235                 240 


Glu Arg Gly Leu Pro Gly Pro Pro Gly Ile Lys Gly Pro Ala Gly Ile 
                245                 250                 255     


Pro Gly Phe Pro Gly Met Lys Gly His Arg Gly Phe Asp Gly Arg Asn 
            260                 265                 270         


Gly Glu Lys Gly Glu Thr Gly Ala Pro Gly Leu Lys Gly Glu Asn Gly 
        275                 280                 285             


Leu Pro Gly Glu Asn Gly Ala Pro Gly Pro Met Gly Pro Arg Gly Ala 
    290                 295                 300                 


Pro Gly Glu Arg Gly Arg Pro Gly Leu Pro Gly Ala Ala Gly Ala Arg 
305                 310                 315                 320 


Gly Asn Asp Gly Ala Arg Gly Ser Asp Gly Gln Pro Gly Pro Pro Gly 
                325                 330                 335     


Pro Pro Gly Thr Ala Gly Phe Pro Gly Ser Pro Gly Ala Lys Gly Glu 
            340                 345                 350         


Val Gly Pro Ala Gly Ser Pro Gly Ser Asn Gly Ala Pro Gly Gln Arg 
        355                 360                 365             


Gly Glu Pro Gly Pro Gln Gly His Ala Gly Ala Gln Gly Pro Pro Gly 
    370                 375                 380                 


Pro Pro Gly Ile Asn Gly Ser Pro Gly Gly Lys Gly Glu Met Gly Pro 
385                 390                 395                 400 


Ala Gly Ile Pro Gly Ala Pro Gly Leu Met Gly Ala Arg Gly Pro Pro 
                405                 410                 415     


Gly Pro Ala Gly Ala Asn Gly Ala Pro Gly Leu Arg Gly Gly Ala Gly 
            420                 425                 430         


Glu Pro Gly Lys Asn Gly Ala Lys Gly Glu Pro Gly Pro Arg Gly Glu 
        435                 440                 445             


Arg Gly Glu Ala Gly Ile Pro Gly Val Pro Gly Ala Lys Gly Glu Asp 
    450                 455                 460                 


Gly Lys Asp Gly Ser Pro Gly Glu Pro Gly Ala Asn Gly Leu Pro Gly 
465                 470                 475                 480 


Ala Ala Gly Glu Arg Gly Ala Pro Gly Phe Arg Gly Pro Ala Gly Pro 
                485                 490                 495     


Asn Gly Ile Pro Gly Glu Lys Gly Pro Ala Gly Glu Arg Gly Ala Pro 
            500                 505                 510         


Gly Pro Ala Gly Pro Arg Gly Ala Ala Gly Glu Pro Gly Arg Asp Gly 
        515                 520                 525             


Val Pro Gly Gly Pro Gly Met Arg Gly Met Pro Gly Ser Pro Gly Gly 
    530                 535                 540                 


Pro Gly Ser Asp Gly Lys Pro Gly Pro Pro Gly Ser Gln Gly Glu Ser 
545                 550                 555                 560 


Gly Arg Pro Gly Pro Pro Gly Pro Ser Gly Pro Arg Gly Gln Pro Gly 
                565                 570                 575     


Val Met Gly Phe Pro Gly Pro Lys Gly Asn Asp Gly Ala Pro Gly Lys 
            580                 585                 590         


Asn Gly Glu Arg Gly Gly Pro Gly Gly Pro Gly Pro Gln Gly Pro Pro 
        595                 600                 605             


Gly Lys Asn Gly Glu Thr Gly Pro Gln Gly Pro Pro Gly Pro Thr Gly 
    610                 615                 620                 


Pro Gly Gly Asp Lys Gly Asp Thr Gly Pro Pro Gly Pro Gln Gly Leu 
625                 630                 635                 640 


Gln Gly Leu Pro Gly Thr Gly Gly Pro Pro Gly Glu Asn Gly Lys Pro 
                645                 650                 655     


Gly Glu Pro Gly Pro Lys Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly 
            660                 665                 670         


Gly Lys Gly Asp Ala Gly Ala Pro Gly Glu Arg Gly Pro Pro Gly Leu 
        675                 680                 685             


Ala Gly Ala Pro Gly Leu Arg Gly Gly Ala Gly Pro Pro Gly Pro Glu 
    690                 695                 700                 


Gly Gly Lys Gly Ala Ala Gly Pro Pro Gly Pro Pro Gly Ala Ala Gly 
705                 710                 715                 720 


Thr Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Gly Leu Gly Ser 
                725                 730                 735     


Pro Gly Pro Lys Gly Asp Lys Gly Glu Pro Gly Gly Pro Gly Ala Asp 
            740                 745                 750         


Gly Val Pro Gly Lys Asp Gly Pro Arg Gly Pro Thr Gly Pro Ile Gly 
        755                 760                 765             


Pro Pro Gly Pro Ala Gly Gln Pro Gly Asp Lys Gly Glu Gly Gly Ala 
    770                 775                 780                 


Pro Gly Leu Pro Gly Ile Ala Gly Pro Arg Gly Ser Pro Gly Glu Arg 
785                 790                 795                 800 


Gly Glu Thr Gly Pro Pro Gly Pro Ala Gly Phe Pro Gly Ala Pro Gly 
                805                 810                 815     


Gln Asn Gly Glu Pro Gly Gly Lys Gly Glu Arg Gly Ala Pro Gly Glu 
            820                 825                 830         


Lys Gly Glu Gly Gly Pro Pro Gly Val Ala Gly Pro Pro Gly Gly Ser 
        835                 840                 845             


Gly Pro Ala Gly Pro Pro Gly Pro Gln Gly Val Lys Gly Glu Arg Gly 
    850                 855                 860                 


Ser Pro Gly Gly Pro Gly Ala Ala Gly Phe Pro Gly Ala Arg Gly Leu 
865                 870                 875                 880 


Pro Gly Pro Pro Gly Ser Asn Gly Asn Pro Gly Pro Pro Gly Pro Ser 
                885                 890                 895     


Gly Ser Pro Gly Lys Asp Gly Pro Pro Gly Pro Ala Gly Asn Thr Gly 
            900                 905                 910         


Ala Pro Gly Ser Pro Gly Val Ser Gly Pro Lys Gly Asp Ala Gly Gln 
        915                 920                 925             


Pro Gly Glu Lys Gly Ser Pro Gly Ala Gln Gly Pro Pro Gly Ala Pro 
    930                 935                 940                 


Gly Pro Leu Gly Ile Ala Gly Ile Thr Gly Ala Arg Gly Leu Ala Gly 
945                 950                 955                 960 


Pro Pro Gly Met Pro Gly Pro Arg Gly Ser Pro Gly Pro Gln Gly Val 
                965                 970                 975     


Lys Gly Glu Ser Gly Lys Pro Gly Ala Asn Gly Leu Ser Gly Glu Arg 
            980                 985                 990         


Gly Pro Pro Gly Pro Gln Gly Leu  Pro Gly Leu Ala Gly  Thr Ala Gly 
        995                 1000                 1005             


Glu Pro  Gly Arg Asp Gly Asn  Pro Gly Ser Asp Gly  Leu Pro Gly 
    1010                 1015                 1020             


Arg Asp  Gly Ser Pro Gly Gly  Lys Gly Asp Arg Gly  Glu Asn Gly 
    1025                 1030                 1035             


Ser Pro  Gly Ala Pro Gly Ala  Pro Gly His Pro Gly  Pro Pro Gly 
    1040                 1045                 1050             


Pro Val  Gly Pro Ala Gly Lys  Ser Gly Asp Arg Gly  Glu Ser Gly 
    1055                 1060                 1065             


Pro Ala  Gly Pro Ala Gly Ala  Pro Gly Pro Ala Gly  Ser Arg Gly 
    1070                 1075                 1080             


Ala Pro  Gly Pro Gln Gly Pro  Arg Gly Asp Lys Gly  Glu Thr Gly 
    1085                 1090                 1095             


Glu Arg  Gly Ala Ala Gly Ile  Lys Gly His Arg Gly  Phe Pro Gly 
    1100                 1105                 1110             


Asn Pro  Gly Ala Pro Gly Ser  Pro Gly Pro Ala Gly  Gln Gln Gly 
    1115                 1120                 1125             


Ala Ile  Gly Ser Pro Gly Pro  Ala Gly Pro Arg Gly  Pro Val Gly 
    1130                 1135                 1140             


Pro Ser  Gly Pro Pro Gly Lys  Asp Gly Thr Ser Gly  His Pro Gly 
    1145                 1150                 1155             


Pro Ile  Gly Pro Pro Gly Pro  Arg Gly Asn Arg Gly  Glu Arg Gly 
    1160                 1165                 1170             


Ser Glu  Gly Ser Pro Gly His  Pro Gly Gln Pro Gly  Pro Pro Gly 
    1175                 1180                 1185             


Pro Pro  Gly Ala Pro Gly Pro  Cys Cys Gly Gly Val  Gly Ala Ala 
    1190                 1195                 1200             


Ala Ile  Ala Gly Ile Gly Gly  Glu Lys Ala Gly Gly  Phe Ala Pro 
    1205                 1210                 1215             


Tyr Tyr  Gly Asp Glu Pro Met  Asp Phe Lys Ile Asn  Thr Asp Glu 
    1220                 1225                 1230             


Ile Met  Thr Ser Leu Lys Ser  Val Asn Gly Gln Ile  Glu Ser Leu 
    1235                 1240                 1245             


Ile Ser  Pro Asp Gly Ser Arg  Lys Asn Pro Ala Arg  Asn Cys Arg 
    1250                 1255                 1260             


Asp Leu  Lys Phe Cys His Pro  Glu Leu Lys Ser Gly  Glu Tyr Trp 
    1265                 1270                 1275             


Val Asp  Pro Asn Gln Gly Cys  Lys Leu Asp Ala Ile  Lys Val Phe 
    1280                 1285                 1290             


Cys Asn  Met Glu Thr Gly Glu  Thr Cys Ile Ser Ala  Asn Pro Leu 
    1295                 1300                 1305             


Asn Val  Pro Arg Lys His Trp  Trp Thr Asp Ser Ser  Ala Glu Lys 
    1310                 1315                 1320             


Lys His  Val Trp Phe Gly Glu  Ser Met Asp Gly Gly  Phe Gln Phe 
    1325                 1330                 1335             


Ser Tyr  Gly Asn Pro Glu Leu  Pro Glu Asp Val Leu  Asp Val His 
    1340                 1345                 1350             


Leu Ala  Phe Leu Arg Leu Leu  Ser Ser Arg Ala Ser  Gln Asn Ile 
    1355                 1360                 1365             


Thr Tyr  His Cys Lys Asn Ser  Ile Ala Tyr Met Asp  Gln Ala Ser 
    1370                 1375                 1380             


Gly Asn  Val Lys Lys Ala Leu  Lys Leu Met Gly Ser  Asn Glu Gly 
    1385                 1390                 1395             


Glu Phe  Lys Ala Glu Gly Asn  Ser Lys Phe Thr Tyr  Thr Val Leu 
    1400                 1405                 1410             


Glu Asp  Gly Cys Thr Lys His  Thr Gly Glu Trp Ser  Lys Thr Val 
    1415                 1420                 1425             


Phe Glu  Tyr Arg Thr Arg Lys  Ala Val Arg Leu Pro  Ile Val Asp 
    1430                 1435                 1440             


Ile Ala  Pro Tyr Asp Ile Gly  Gly Pro Asp Gln Glu  Phe Gly Val 
    1445                 1450                 1455             


Asp Val  Gly Pro Val Cys Phe  Leu 
    1460                 1465     


<210>  3288
<211>  1163
<212>  PRT
<213>  Homo Sapiens

<400>  3288

Met Met Ser Phe Val Gln Lys Gly Ser Trp Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


His Pro Thr Ile Ile Leu Ala Gln Gln Glu Ala Val Glu Gly Gly Cys 
            20                  25                  30          


Ser His Leu Gly Gln Ser Tyr Ala Asp Arg Asp Val Trp Lys Pro Glu 
        35                  40                  45              


Pro Cys Gln Ile Cys Val Cys Asp Ser Gly Ser Val Leu Cys Asp Asp 
    50                  55                  60                  


Ile Ile Cys Asp Asp Gln Glu Leu Asp Cys Pro Asn Pro Glu Ile Pro 
65                  70                  75                  80  


Phe Gly Glu Cys Cys Ala Val Cys Pro Gln Pro Pro Thr Ala Pro Thr 
                85                  90                  95      


Arg Pro Pro Asn Gly Gln Gly Pro Gln Gly Pro Lys Gly Asp Pro Gly 
            100                 105                 110         


Pro Pro Gly Ile Pro Gly Arg Asn Gly Asp Pro Gly Ile Pro Gly Gln 
        115                 120                 125             


Pro Gly Ser Pro Gly Ser Pro Gly Pro Pro Gly Ile Cys Glu Ser Cys 
    130                 135                 140                 


Pro Thr Gly Pro Gln Asn Tyr Ser Pro Gln Tyr Asp Ser Tyr Asp Val 
145                 150                 155                 160 


Lys Ser Gly Val Ala Val Gly Gly Leu Ala Gly Tyr Pro Gly Pro Ala 
                165                 170                 175     


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Thr Ser Gly His Pro Gly 
            180                 185                 190         


Ser Pro Gly Ser Pro Gly Tyr Gln Gly Pro Pro Gly Glu Pro Gly Gln 
        195                 200                 205             


Ala Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly Ala Ile Gly Pro Ser 
    210                 215                 220                 


Gly Pro Ala Gly Lys Asp Gly Glu Ser Gly Arg Pro Gly Arg Pro Gly 
225                 230                 235                 240 


Glu Arg Gly Leu Pro Gly Pro Pro Gly Ile Lys Gly Pro Ala Gly Ile 
                245                 250                 255     


Pro Gly Phe Pro Gly Met Lys Gly His Arg Gly Phe Asp Gly Arg Asn 
            260                 265                 270         


Gly Glu Lys Gly Glu Thr Gly Ala Pro Gly Leu Lys Gly Glu Asn Gly 
        275                 280                 285             


Leu Pro Gly Glu Asn Gly Ala Pro Gly Pro Met Gly Pro Arg Gly Ala 
    290                 295                 300                 


Pro Gly Glu Arg Gly Arg Pro Gly Leu Pro Gly Ala Ala Gly Ala Arg 
305                 310                 315                 320 


Gly Asn Asp Gly Ala Arg Gly Ser Asp Gly Gln Pro Gly Pro Pro Gly 
                325                 330                 335     


Pro Pro Gly Thr Ala Gly Phe Pro Gly Ser Pro Gly Ala Lys Gly Glu 
            340                 345                 350         


Val Gly Pro Ala Gly Ser Pro Gly Ser Asn Gly Ala Pro Gly Gln Arg 
        355                 360                 365             


Gly Glu Pro Gly Pro Gln Gly His Ala Gly Ala Gln Gly Pro Pro Gly 
    370                 375                 380                 


Pro Pro Gly Ile Asn Gly Ser Pro Gly Gly Lys Gly Glu Met Gly Pro 
385                 390                 395                 400 


Ala Gly Ile Pro Gly Ala Pro Gly Leu Met Gly Ala Arg Gly Pro Pro 
                405                 410                 415     


Gly Pro Ala Gly Ala Asn Gly Ala Pro Gly Leu Arg Gly Gly Ala Gly 
            420                 425                 430         


Glu Pro Gly Lys Asn Gly Ala Lys Gly Glu Pro Gly Pro Arg Gly Glu 
        435                 440                 445             


Arg Gly Glu Ala Gly Ile Pro Gly Val Pro Gly Ala Lys Gly Glu Asp 
    450                 455                 460                 


Gly Lys Asp Gly Ser Pro Gly Glu Pro Gly Ala Asn Gly Leu Pro Gly 
465                 470                 475                 480 


Ala Ala Gly Glu Arg Gly Ala Pro Gly Phe Arg Gly Pro Ala Gly Pro 
                485                 490                 495     


Asn Gly Ile Pro Gly Glu Lys Gly Pro Ala Gly Glu Arg Gly Ala Pro 
            500                 505                 510         


Gly Pro Ala Gly Pro Arg Gly Ala Ala Gly Glu Pro Gly Arg Asp Gly 
        515                 520                 525             


Val Pro Gly Gly Pro Gly Met Arg Gly Met Pro Gly Ser Pro Gly Gly 
    530                 535                 540                 


Pro Gly Ser Asp Gly Lys Pro Gly Pro Pro Gly Ser Gln Gly Glu Ser 
545                 550                 555                 560 


Gly Arg Pro Gly Pro Pro Gly Pro Ser Gly Pro Arg Gly Gln Pro Gly 
                565                 570                 575     


Val Met Gly Phe Pro Gly Pro Lys Gly Asn Asp Gly Ala Pro Gly Lys 
            580                 585                 590         


Asn Gly Glu Arg Gly Gly Pro Gly Gly Pro Gly Pro Gln Gly Pro Pro 
        595                 600                 605             


Gly Lys Asn Gly Glu Thr Gly Pro Gln Gly Pro Pro Gly Pro Thr Gly 
    610                 615                 620                 


Pro Gly Gly Asp Lys Gly Asp Thr Gly Pro Pro Gly Pro Gln Gly Leu 
625                 630                 635                 640 


Gln Gly Leu Pro Gly Thr Gly Gly Pro Pro Gly Glu Asn Gly Lys Pro 
                645                 650                 655     


Gly Glu Pro Gly Pro Lys Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly 
            660                 665                 670         


Gly Lys Gly Asp Ala Gly Ala Pro Gly Glu Arg Gly Pro Pro Gly Leu 
        675                 680                 685             


Ala Gly Ala Pro Gly Leu Arg Gly Gly Ala Gly Pro Pro Gly Pro Glu 
    690                 695                 700                 


Gly Gly Lys Gly Ala Ala Gly Pro Pro Gly Pro Pro Gly Ala Ala Gly 
705                 710                 715                 720 


Thr Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Gly Leu Gly Ser 
                725                 730                 735     


Pro Gly Pro Lys Gly Asp Lys Gly Glu Pro Gly Gly Pro Gly Ala Asp 
            740                 745                 750         


Gly Val Pro Gly Lys Asp Gly Pro Arg Gly Pro Thr Gly Pro Ile Gly 
        755                 760                 765             


Pro Pro Gly Pro Ala Gly Gln Pro Gly Asp Lys Gly Glu Gly Gly Ala 
    770                 775                 780                 


Pro Gly Leu Pro Gly Ile Ala Gly Pro Arg Gly Ser Pro Gly Glu Arg 
785                 790                 795                 800 


Gly Glu Thr Gly Pro Pro Gly Pro Ala Gly Phe Pro Gly Ala Pro Gly 
                805                 810                 815     


Gln Asn Gly Glu Pro Gly Gly Lys Gly Glu Arg Gly Ala Pro Gly Glu 
            820                 825                 830         


Lys Gly Glu Gly Gly Pro Pro Gly Val Ala Gly Pro Pro Gly Lys Asp 
        835                 840                 845             


Gly Thr Ser Gly His Pro Gly Pro Ile Gly Pro Pro Gly Pro Arg Gly 
    850                 855                 860                 


Asn Arg Gly Glu Arg Gly Ser Glu Gly Ser Pro Gly His Pro Gly Gln 
865                 870                 875                 880 


Pro Gly Pro Pro Gly Pro Pro Gly Ala Pro Gly Pro Cys Cys Gly Gly 
                885                 890                 895     


Val Gly Ala Ala Ala Ile Ala Gly Ile Gly Gly Glu Lys Ala Gly Gly 
            900                 905                 910         


Phe Ala Pro Tyr Tyr Gly Asp Glu Pro Met Asp Phe Lys Ile Asn Thr 
        915                 920                 925             


Asp Glu Ile Met Thr Ser Leu Lys Ser Val Asn Gly Gln Ile Glu Ser 
    930                 935                 940                 


Leu Ile Ser Pro Asp Gly Ser Arg Lys Asn Pro Ala Arg Asn Cys Arg 
945                 950                 955                 960 


Asp Leu Lys Phe Cys His Pro Glu Leu Lys Ser Gly Glu Tyr Trp Val 
                965                 970                 975     


Asp Pro Asn Gln Gly Cys Lys Leu Asp Ala Ile Lys Val Phe Cys Asn 
            980                 985                 990         


Met Glu Thr Gly Glu Thr Cys Ile  Ser Ala Asn Pro Leu  Asn Val Pro 
        995                 1000                 1005             


Arg Lys  His Trp Trp Thr Asp  Ser Ser Ala Glu Lys  Lys His Val 
    1010                 1015                 1020             


Trp Phe  Gly Glu Ser Met Asp  Gly Gly Phe Gln Phe  Ser Tyr Gly 
    1025                 1030                 1035             


Asn Pro  Glu Leu Pro Glu Asp  Val Leu Asp Val His  Leu Ala Phe 
    1040                 1045                 1050             


Leu Arg  Leu Leu Ser Ser Arg  Ala Ser Gln Asn Ile  Thr Tyr His 
    1055                 1060                 1065             


Cys Lys  Asn Ser Ile Ala Tyr  Met Asp Gln Ala Ser  Gly Asn Val 
    1070                 1075                 1080             


Lys Lys  Ala Leu Lys Leu Met  Gly Ser Asn Glu Gly  Glu Phe Lys 
    1085                 1090                 1095             


Ala Glu  Gly Asn Ser Lys Phe  Thr Tyr Thr Val Leu  Glu Asp Gly 
    1100                 1105                 1110             


Cys Thr  Lys His Thr Gly Glu  Trp Ser Lys Thr Val  Phe Glu Tyr 
    1115                 1120                 1125             


Arg Thr  Arg Lys Ala Val Arg  Leu Pro Ile Val Asp  Ile Ala Pro 
    1130                 1135                 1140             


Tyr Asp  Ile Gly Gly Pro Asp  Gln Glu Phe Gly Val  Asp Val Gly 
    1145                 1150                 1155             


Pro Val  Cys Phe Leu 
    1160             


<210>  3289
<211>  90
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3289

Xaa Arg Gly Ala Pro Gly Glu Arg Gly Arg Pro Gly Leu Pro Gly Ala 
1               5                   10                  15      


Ala Gly Ala Arg Gly Asn Asp Gly Ala Arg Gly Ser Asp Gly Gln Pro 
            20                  25                  30          


Gly Pro Pro Gly Pro Pro Gly Thr Ala Gly Phe Pro Gly Ser Pro Gly 
        35                  40                  45              


Ala Lys Gly Pro Pro Gly Ile Asn Gly Ser Pro Gly Gly Lys Gly Glu 
    50                  55                  60                  


Met Gly Pro Ala Gly Ile Pro Gly Ala Pro Gly Leu Met Gly Ala Arg 
65                  70                  75                  80  


Gly Pro Pro Gly Pro Ala Gly Ala Asn Gly 
                85                  90  


<210>  3290
<211>  1669
<212>  PRT
<213>  Homo Sapiens

<400>  3290

Met Gly Pro Arg Leu Ser Val Trp Leu Leu Leu Leu Pro Ala Ala Leu 
1               5                   10                  15      


Leu Leu His Glu Glu His Ser Arg Ala Ala Ala Lys Gly Gly Cys Ala 
            20                  25                  30          


Gly Ser Gly Cys Gly Lys Cys Asp Cys His Gly Val Lys Gly Gln Lys 
        35                  40                  45              


Gly Glu Arg Gly Leu Pro Gly Leu Gln Gly Val Ile Gly Phe Pro Gly 
    50                  55                  60                  


Met Gln Gly Pro Glu Gly Pro Gln Gly Pro Pro Gly Gln Lys Gly Asp 
65                  70                  75                  80  


Thr Gly Glu Pro Gly Leu Pro Gly Thr Lys Gly Thr Arg Gly Pro Pro 
                85                  90                  95      


Gly Ala Ser Gly Tyr Pro Gly Asn Pro Gly Leu Pro Gly Ile Pro Gly 
            100                 105                 110         


Gln Asp Gly Pro Pro Gly Pro Pro Gly Ile Pro Gly Cys Asn Gly Thr 
        115                 120                 125             


Lys Gly Glu Arg Gly Pro Leu Gly Pro Pro Gly Leu Pro Gly Phe Ala 
    130                 135                 140                 


Gly Asn Pro Gly Pro Pro Gly Leu Pro Gly Met Lys Gly Asp Pro Gly 
145                 150                 155                 160 


Glu Ile Leu Gly His Val Pro Gly Met Leu Leu Lys Gly Glu Arg Gly 
                165                 170                 175     


Phe Pro Gly Ile Pro Gly Thr Pro Gly Pro Pro Gly Leu Pro Gly Leu 
            180                 185                 190         


Gln Gly Pro Val Gly Pro Pro Gly Phe Thr Gly Pro Pro Gly Pro Pro 
        195                 200                 205             


Gly Pro Pro Gly Pro Pro Gly Glu Lys Gly Gln Met Gly Leu Ser Phe 
    210                 215                 220                 


Gln Gly Pro Lys Gly Asp Lys Gly Asp Gln Gly Val Ser Gly Pro Pro 
225                 230                 235                 240 


Gly Val Pro Gly Gln Ala Gln Val Gln Glu Lys Gly Asp Phe Ala Thr 
                245                 250                 255     


Lys Gly Glu Lys Gly Gln Lys Gly Glu Pro Gly Phe Gln Gly Met Pro 
            260                 265                 270         


Gly Val Gly Glu Lys Gly Glu Pro Gly Lys Pro Gly Pro Arg Gly Lys 
        275                 280                 285             


Pro Gly Lys Asp Gly Asp Lys Gly Glu Lys Gly Ser Pro Gly Phe Pro 
    290                 295                 300                 


Gly Glu Pro Gly Tyr Pro Gly Leu Ile Gly Arg Gln Gly Pro Gln Gly 
305                 310                 315                 320 


Glu Lys Gly Glu Ala Gly Pro Pro Gly Pro Pro Gly Ile Val Ile Gly 
                325                 330                 335     


Thr Gly Pro Leu Gly Glu Lys Gly Glu Arg Gly Tyr Pro Gly Thr Pro 
            340                 345                 350         


Gly Pro Arg Gly Glu Pro Gly Pro Lys Gly Phe Pro Gly Leu Pro Gly 
        355                 360                 365             


Gln Pro Gly Pro Pro Gly Leu Pro Val Pro Gly Gln Ala Gly Ala Pro 
    370                 375                 380                 


Gly Phe Pro Gly Glu Arg Gly Glu Lys Gly Asp Arg Gly Phe Pro Gly 
385                 390                 395                 400 


Thr Ser Leu Pro Gly Pro Ser Gly Arg Asp Gly Leu Pro Gly Pro Pro 
                405                 410                 415     


Gly Ser Pro Gly Pro Pro Gly Gln Pro Gly Tyr Thr Asn Gly Ile Val 
            420                 425                 430         


Glu Cys Gln Pro Gly Pro Pro Gly Asp Gln Gly Pro Pro Gly Ile Pro 
        435                 440                 445             


Gly Gln Pro Gly Phe Ile Gly Glu Ile Gly Glu Lys Gly Gln Lys Gly 
    450                 455                 460                 


Glu Ser Cys Leu Ile Cys Asp Ile Asp Gly Tyr Arg Gly Pro Pro Gly 
465                 470                 475                 480 


Pro Gln Gly Pro Pro Gly Glu Ile Gly Phe Pro Gly Gln Pro Gly Ala 
                485                 490                 495     


Lys Gly Asp Arg Gly Leu Pro Gly Arg Asp Gly Val Ala Gly Val Pro 
            500                 505                 510         


Gly Pro Gln Gly Thr Pro Gly Leu Ile Gly Gln Pro Gly Ala Lys Gly 
        515                 520                 525             


Glu Pro Gly Glu Phe Tyr Phe Asp Leu Arg Leu Lys Gly Asp Lys Gly 
    530                 535                 540                 


Asp Pro Gly Phe Pro Gly Gln Pro Gly Met Pro Gly Arg Ala Gly Ser 
545                 550                 555                 560 


Pro Gly Arg Asp Gly His Pro Gly Leu Pro Gly Pro Lys Gly Ser Pro 
                565                 570                 575     


Gly Ser Val Gly Leu Lys Gly Glu Arg Gly Pro Pro Gly Gly Val Gly 
            580                 585                 590         


Phe Pro Gly Ser Arg Gly Asp Thr Gly Pro Pro Gly Pro Pro Gly Tyr 
        595                 600                 605             


Gly Pro Ala Gly Pro Ile Gly Asp Lys Gly Gln Ala Gly Phe Pro Gly 
    610                 615                 620                 


Gly Pro Gly Ser Pro Gly Leu Pro Gly Pro Lys Gly Glu Pro Gly Lys 
625                 630                 635                 640 


Ile Val Pro Leu Pro Gly Pro Pro Gly Ala Glu Gly Leu Pro Gly Ser 
                645                 650                 655     


Pro Gly Phe Pro Gly Pro Gln Gly Asp Arg Gly Phe Pro Gly Thr Pro 
            660                 665                 670         


Gly Arg Pro Gly Leu Pro Gly Glu Lys Gly Ala Val Gly Gln Pro Gly 
        675                 680                 685             


Ile Gly Phe Pro Gly Pro Pro Gly Pro Lys Gly Val Asp Gly Leu Pro 
    690                 695                 700                 


Gly Asp Met Gly Pro Pro Gly Thr Pro Gly Arg Pro Gly Phe Asn Gly 
705                 710                 715                 720 


Leu Pro Gly Asn Pro Gly Val Gln Gly Gln Lys Gly Glu Pro Gly Val 
                725                 730                 735     


Gly Leu Pro Gly Leu Lys Gly Leu Pro Gly Leu Pro Gly Ile Pro Gly 
            740                 745                 750         


Thr Pro Gly Glu Lys Gly Ser Ile Gly Val Pro Gly Val Pro Gly Glu 
        755                 760                 765             


His Gly Ala Ile Gly Pro Pro Gly Leu Gln Gly Ile Arg Gly Glu Pro 
    770                 775                 780                 


Gly Pro Pro Gly Leu Pro Gly Ser Val Gly Ser Pro Gly Val Pro Gly 
785                 790                 795                 800 


Ile Gly Pro Pro Gly Ala Arg Gly Pro Pro Gly Gly Gln Gly Pro Pro 
                805                 810                 815     


Gly Leu Ser Gly Pro Pro Gly Ile Lys Gly Glu Lys Gly Phe Pro Gly 
            820                 825                 830         


Phe Pro Gly Leu Asp Met Pro Gly Pro Lys Gly Asp Lys Gly Ala Gln 
        835                 840                 845             


Gly Leu Pro Gly Ile Thr Gly Gln Ser Gly Leu Pro Gly Leu Pro Gly 
    850                 855                 860                 


Gln Gln Gly Ala Pro Gly Ile Pro Gly Phe Pro Gly Ser Lys Gly Glu 
865                 870                 875                 880 


Met Gly Val Met Gly Thr Pro Gly Gln Pro Gly Ser Pro Gly Pro Val 
                885                 890                 895     


Gly Ala Pro Gly Leu Pro Gly Glu Lys Gly Asp His Gly Phe Pro Gly 
            900                 905                 910         


Ser Ser Gly Pro Arg Gly Asp Pro Gly Leu Lys Gly Asp Lys Gly Asp 
        915                 920                 925             


Val Gly Leu Pro Gly Lys Pro Gly Ser Met Asp Lys Val Asp Met Gly 
    930                 935                 940                 


Ser Met Lys Gly Gln Lys Gly Asp Gln Gly Glu Lys Gly Gln Ile Gly 
945                 950                 955                 960 


Pro Ile Gly Glu Lys Gly Ser Arg Gly Asp Pro Gly Thr Pro Gly Val 
                965                 970                 975     


Pro Gly Lys Asp Gly Gln Ala Gly Gln Pro Gly Gln Pro Gly Pro Lys 
            980                 985                 990         


Gly Asp Pro Gly Ile Ser Gly Thr  Pro Gly Ala Pro Gly  Leu Pro Gly 
        995                 1000                 1005             


Pro Lys  Gly Ser Val Gly Gly  Met Gly Leu Pro Gly  Thr Pro Gly 
    1010                 1015                 1020             


Glu Lys  Gly Val Pro Gly Ile  Pro Gly Pro Gln Gly  Ser Pro Gly 
    1025                 1030                 1035             


Leu Pro  Gly Asp Lys Gly Ala  Lys Gly Glu Lys Gly  Gln Ala Gly 
    1040                 1045                 1050             


Pro Pro  Gly Ile Gly Ile Pro  Gly Leu Arg Gly Glu  Lys Gly Asp 
    1055                 1060                 1065             


Gln Gly  Ile Ala Gly Phe Pro  Gly Ser Pro Gly Glu  Lys Gly Glu 
    1070                 1075                 1080             


Lys Gly  Ser Ile Gly Ile Pro  Gly Met Pro Gly Ser  Pro Gly Leu 
    1085                 1090                 1095             


Lys Gly  Ser Pro Gly Ser Val  Gly Tyr Pro Gly Ser  Pro Gly Leu 
    1100                 1105                 1110             


Pro Gly  Glu Lys Gly Asp Lys  Gly Leu Pro Gly Leu  Asp Gly Ile 
    1115                 1120                 1125             


Pro Gly  Val Lys Gly Glu Ala  Gly Leu Pro Gly Thr  Pro Gly Pro 
    1130                 1135                 1140             


Thr Gly  Pro Ala Gly Gln Lys  Gly Glu Pro Gly Ser  Asp Gly Ile 
    1145                 1150                 1155             


Pro Gly  Ser Ala Gly Glu Lys  Gly Glu Pro Gly Leu  Pro Gly Arg 
    1160                 1165                 1170             


Gly Phe  Pro Gly Phe Pro Gly  Ala Lys Gly Asp Lys  Gly Ser Lys 
    1175                 1180                 1185             


Gly Glu  Val Gly Phe Pro Gly  Leu Ala Gly Ser Pro  Gly Ile Pro 
    1190                 1195                 1200             


Gly Ser  Lys Gly Glu Gln Gly  Phe Met Gly Pro Pro  Gly Pro Gln 
    1205                 1210                 1215             


Gly Gln  Pro Gly Leu Pro Gly  Ser Pro Gly His Ala  Thr Glu Gly 
    1220                 1225                 1230             


Pro Lys  Gly Asp Arg Gly Pro  Gln Gly Gln Pro Gly  Leu Pro Gly 
    1235                 1240                 1245             


Leu Pro  Gly Pro Met Gly Pro  Pro Gly Leu Pro Gly  Ile Asp Gly 
    1250                 1255                 1260             


Val Lys  Gly Asp Lys Gly Asn  Pro Gly Trp Pro Gly  Ala Pro Gly 
    1265                 1270                 1275             


Val Pro  Gly Pro Lys Gly Asp  Pro Gly Phe Gln Gly  Met Pro Gly 
    1280                 1285                 1290             


Ile Gly  Gly Ser Pro Gly Ile  Thr Gly Ser Lys Gly  Asp Met Gly 
    1295                 1300                 1305             


Pro Pro  Gly Val Pro Gly Phe  Gln Gly Pro Lys Gly  Leu Pro Gly 
    1310                 1315                 1320             


Leu Gln  Gly Ile Lys Gly Asp  Gln Gly Asp Gln Gly  Val Pro Gly 
    1325                 1330                 1335             


Ala Lys  Gly Leu Pro Gly Pro  Pro Gly Pro Pro Gly  Pro Tyr Asp 
    1340                 1345                 1350             


Ile Ile  Lys Gly Glu Pro Gly  Leu Pro Gly Pro Glu  Gly Pro Pro 
    1355                 1360                 1365             


Gly Leu  Lys Gly Leu Gln Gly  Leu Pro Gly Pro Lys  Gly Gln Gln 
    1370                 1375                 1380             


Gly Val  Thr Gly Leu Val Gly  Ile Pro Gly Pro Pro  Gly Ile Pro 
    1385                 1390                 1395             


Gly Phe  Asp Gly Ala Pro Gly  Gln Lys Gly Glu Met  Gly Pro Ala 
    1400                 1405                 1410             


Gly Pro  Thr Gly Pro Arg Gly  Phe Pro Gly Pro Pro  Gly Pro Asp 
    1415                 1420                 1425             


Gly Leu  Pro Gly Ser Met Gly  Pro Pro Gly Thr Pro  Ser Val Asp 
    1430                 1435                 1440             


His Gly  Phe Leu Val Thr Arg  His Ser Gln Thr Ile  Asp Asp Pro 
    1445                 1450                 1455             


Gln Cys  Pro Ser Gly Thr Lys  Ile Leu Tyr His Gly  Tyr Ser Leu 
    1460                 1465                 1470             


Leu Tyr  Val Gln Gly Asn Glu  Arg Ala His Gly Gln  Asp Leu Gly 
    1475                 1480                 1485             


Thr Ala  Gly Ser Cys Leu Arg  Lys Phe Ser Thr Met  Pro Phe Leu 
    1490                 1495                 1500             


Phe Cys  Asn Ile Asn Asn Val  Cys Asn Phe Ala Ser  Arg Asn Asp 
    1505                 1510                 1515             


Tyr Ser  Tyr Trp Leu Ser Thr  Pro Glu Pro Met Pro  Met Ser Met 
    1520                 1525                 1530             


Ala Pro  Ile Thr Gly Glu Asn  Ile Arg Pro Phe Ile  Ser Arg Cys 
    1535                 1540                 1545             


Ala Val  Cys Glu Ala Pro Ala  Met Val Met Ala Val  His Ser Gln 
    1550                 1555                 1560             


Thr Ile  Gln Ile Pro Pro Cys  Pro Ser Gly Trp Ser  Ser Leu Trp 
    1565                 1570                 1575             


Ile Gly  Tyr Ser Phe Val Met  His Thr Ser Ala Gly  Ala Glu Gly 
    1580                 1585                 1590             


Ser Gly  Gln Ala Leu Ala Ser  Pro Gly Ser Cys Leu  Glu Glu Phe 
    1595                 1600                 1605             


Arg Ser  Ala Pro Phe Ile Glu  Cys His Gly Arg Gly  Thr Cys Asn 
    1610                 1615                 1620             


Tyr Tyr  Ala Asn Ala Tyr Ser  Phe Trp Leu Ala Thr  Ile Glu Arg 
    1625                 1630                 1635             


Ser Glu  Met Phe Lys Lys Pro  Thr Pro Ser Thr Leu  Lys Ala Gly 
    1640                 1645                 1650             


Glu Leu  Arg Thr His Val Ser  Arg Cys Gln Val Cys  Met Arg Arg 
    1655                 1660                 1665             


Thr 
    


<210>  3291
<211>  519
<212>  PRT
<213>  Homo Sapiens

<400>  3291

Met Gly Pro Arg Leu Ser Val Trp Leu Leu Leu Leu Pro Ala Ala Leu 
1               5                   10                  15      


Leu Leu His Glu Glu His Ser Arg Ala Ala Ala Lys Gly Gly Cys Ala 
            20                  25                  30          


Gly Ser Gly Cys Gly Lys Cys Asp Cys His Gly Val Lys Gly Gln Lys 
        35                  40                  45              


Gly Glu Arg Gly Leu Pro Gly Leu Gln Gly Val Ile Gly Phe Pro Gly 
    50                  55                  60                  


Met Gln Gly Pro Glu Gly Pro Gln Gly Pro Pro Gly Gln Lys Gly Asp 
65                  70                  75                  80  


Thr Gly Glu Pro Gly Leu Pro Gly Thr Lys Gly Thr Arg Gly Pro Pro 
                85                  90                  95      


Gly Ala Ser Gly Tyr Pro Gly Asn Pro Gly Leu Pro Gly Ile Pro Gly 
            100                 105                 110         


Gln Asp Gly Pro Pro Gly Pro Pro Gly Ile Pro Gly Cys Asn Gly Thr 
        115                 120                 125             


Lys Gly Glu Arg Gly Pro Leu Gly Pro Pro Gly Leu Pro Gly Phe Ala 
    130                 135                 140                 


Gly Asn Pro Gly Pro Pro Gly Leu Pro Gly Met Lys Gly Asp Pro Gly 
145                 150                 155                 160 


Glu Ile Leu Gly His Val Pro Gly Met Leu Leu Lys Gly Glu Arg Gly 
                165                 170                 175     


Phe Pro Gly Ile Pro Gly Thr Pro Gly Pro Pro Gly Leu Pro Gly Leu 
            180                 185                 190         


Gln Gly Pro Val Gly Pro Pro Gly Phe Thr Gly Pro Pro Gly Pro Pro 
        195                 200                 205             


Gly Pro Pro Gly Pro Pro Gly Glu Lys Gly Gln Met Gly Leu Ser Phe 
    210                 215                 220                 


Gln Gly Pro Lys Gly Asp Lys Gly Asp Gln Gly Val Ser Gly Pro Pro 
225                 230                 235                 240 


Gly Val Pro Gly Gln Ala Gln Val Gln Glu Lys Gly Asp Phe Ala Thr 
                245                 250                 255     


Lys Gly Glu Lys Gly Gln Lys Gly Glu Pro Gly Phe Gln Gly Met Pro 
            260                 265                 270         


Gly Val Gly Glu Lys Gly Glu Pro Gly Lys Pro Gly Pro Arg Gly Lys 
        275                 280                 285             


Pro Gly Lys Asp Gly Asp Lys Gly Glu Lys Gly Ser Pro Gly Phe Pro 
    290                 295                 300                 


Gly Glu Pro Gly Tyr Pro Gly Leu Ile Gly Arg Gln Gly Pro Gln Gly 
305                 310                 315                 320 


Glu Lys Gly Glu Ala Gly Pro Pro Gly Pro Pro Gly Ile Val Ile Gly 
                325                 330                 335     


Thr Gly Pro Leu Gly Glu Lys Gly Glu Arg Gly Tyr Pro Gly Thr Pro 
            340                 345                 350         


Gly Pro Arg Gly Glu Pro Gly Pro Lys Gly Phe Pro Gly Leu Pro Gly 
        355                 360                 365             


Gln Pro Gly Pro Pro Gly Leu Pro Val Pro Gly Gln Ala Gly Ala Pro 
    370                 375                 380                 


Gly Phe Pro Gly Glu Arg Gly Glu Lys Gly Asp Arg Gly Phe Pro Gly 
385                 390                 395                 400 


Thr Ser Leu Pro Gly Pro Ser Gly Arg Asp Gly Leu Pro Gly Pro Pro 
                405                 410                 415     


Gly Ser Pro Gly Pro Pro Gly Gln Pro Gly Tyr Thr Asn Gly Ile Val 
            420                 425                 430         


Glu Cys Gln Pro Gly Pro Pro Gly Asp Gln Gly Pro Pro Gly Ile Pro 
        435                 440                 445             


Gly Gln Pro Gly Phe Ile Gly Glu Ile Gly Glu Lys Gly Gln Lys Gly 
    450                 455                 460                 


Glu Ser Cys Leu Ile Cys Asp Ile Asp Gly Tyr Arg Gly Pro Pro Gly 
465                 470                 475                 480 


Pro Gln Gly Pro Pro Gly Glu Ile Gly Phe Pro Gly Gln Pro Gly Ala 
                485                 490                 495     


Lys Gly Asp Arg Gly Leu Pro Gly Arg Asp Gly Val Ala Gly Val Pro 
            500                 505                 510         


Leu Leu Phe Gln Ile His Lys 
        515                 


<210>  3292
<211>  223
<212>  PRT
<213>  Homo Sapiens

<400>  3292

Met Gln Gly Pro Glu Gly Pro Gln Gly Pro Pro Gly Gln Lys Gly Asp 
1               5                   10                  15      


Thr Gly Glu Pro Gly Leu Pro Gly Thr Lys Gly Thr Arg Gly Pro Pro 
            20                  25                  30          


Gly Ala Ser Gly Tyr Pro Gly Asn Pro Gly Leu Pro Gly Ile Pro Gly 
        35                  40                  45              


Gln Asp Gly Pro Pro Gly Pro Pro Gly Ile Pro Gly Cys Asn Gly Thr 
    50                  55                  60                  


Lys Gly Glu Arg Gly Pro Leu Gly Pro Pro Gly Leu Pro Gly Phe Ala 
65                  70                  75                  80  


Gly Asn Pro Gly Pro Pro Gly Leu Pro Gly Met Lys Gly Asp Pro Gly 
                85                  90                  95      


Glu Ile Leu Gly His Val Pro Gly Met Leu Leu Lys Gly Glu Arg Gly 
            100                 105                 110         


Phe Pro Gly Ile Pro Gly Thr Pro Gly Pro Pro Gly Leu Pro Gly Leu 
        115                 120                 125             


Gln Gly Pro Val Gly Pro Pro Gly Phe Thr Gly Pro Pro Gly Pro Pro 
    130                 135                 140                 


Gly Pro Pro Gly Pro Pro Gly Glu Lys Gly Gln Met Gly Leu Ser Phe 
145                 150                 155                 160 


Gln Gly Pro Lys Gly Asp Lys Gly Asp Gln Gly Val Ser Gly Pro Pro 
                165                 170                 175     


Gly Val Pro Gly Gln Ala Gln Val Gln Glu Lys Gly Asp Phe Ala Thr 
            180                 185                 190         


Lys Gly Glu Lys Gly Gln Lys Gly Glu Pro Gly Phe Gln Gly Met Pro 
        195                 200                 205             


Gly Val Gly Glu Lys Gly Glu Pro Gly Lys Pro Gly Pro Arg Val 
    210                 215                 220             


<210>  3293
<211>  105
<212>  PRT
<213>  Homo Sapiens

<400>  3293

Met Gly Arg Asp Gln Arg Ala Val Ala Gly Pro Ala Leu Arg Arg Trp 
1               5                   10                  15      


Leu Leu Leu Gly Thr Val Thr Val Gly Phe Leu Ala Gln Ser Val Leu 
            20                  25                  30          


Ala Gly Val Lys Lys Phe Asp Val Pro Cys Gly Gly Arg Asp Cys Ser 
        35                  40                  45              


Gly Gly Cys Gln Cys Tyr Pro Glu Lys Gly Gly Arg Gly Gln Pro Gly 
    50                  55                  60                  


Pro Val Gly Pro Gln Gly Tyr Asn Gly Pro Pro Gly Leu Gln Gly Phe 
65                  70                  75                  80  


Pro Gly Leu Gln Gly Arg Lys Gly Asp Lys Gly Glu Arg Gly Ala Pro 
                85                  90                  95      


Gly Val Thr Gly Pro Lys Gly Asp Val 
            100                 105 


<210>  3294
<211>  1712
<212>  PRT
<213>  Homo Sapiens

<400>  3294

Met Gly Arg Asp Gln Arg Ala Val Ala Gly Pro Ala Leu Arg Arg Trp 
1               5                   10                  15      


Leu Leu Leu Gly Thr Val Thr Val Gly Phe Leu Ala Gln Ser Val Leu 
            20                  25                  30          


Ala Gly Val Lys Lys Phe Asp Val Pro Cys Gly Gly Arg Asp Cys Ser 
        35                  40                  45              


Gly Gly Cys Gln Cys Tyr Pro Glu Lys Gly Gly Arg Gly Gln Pro Gly 
    50                  55                  60                  


Pro Val Gly Pro Gln Gly Tyr Asn Gly Pro Pro Gly Leu Gln Gly Phe 
65                  70                  75                  80  


Pro Gly Leu Gln Gly Arg Lys Gly Asp Lys Gly Glu Arg Gly Ala Pro 
                85                  90                  95      


Gly Val Thr Gly Pro Lys Gly Asp Val Gly Ala Arg Gly Val Ser Gly 
            100                 105                 110         


Phe Pro Gly Ala Asp Gly Ile Pro Gly His Pro Gly Gln Gly Gly Pro 
        115                 120                 125             


Arg Gly Arg Pro Gly Tyr Asp Gly Cys Asn Gly Thr Gln Gly Asp Ser 
    130                 135                 140                 


Gly Pro Gln Gly Pro Pro Gly Ser Glu Gly Phe Thr Gly Pro Pro Gly 
145                 150                 155                 160 


Pro Gln Gly Pro Lys Gly Gln Lys Gly Glu Pro Tyr Ala Leu Pro Lys 
                165                 170                 175     


Glu Glu Arg Asp Arg Tyr Arg Gly Glu Pro Gly Glu Pro Gly Leu Val 
            180                 185                 190         


Gly Phe Gln Gly Pro Pro Gly Arg Pro Gly His Val Gly Gln Met Gly 
        195                 200                 205             


Pro Val Gly Ala Pro Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Pro 
    210                 215                 220                 


Lys Gly Gln Gln Gly Asn Arg Gly Leu Gly Phe Tyr Gly Val Lys Gly 
225                 230                 235                 240 


Glu Lys Gly Asp Val Gly Gln Pro Gly Pro Asn Gly Ile Pro Ser Asp 
                245                 250                 255     


Thr Leu His Pro Ile Ile Ala Pro Thr Gly Val Thr Phe His Pro Asp 
            260                 265                 270         


Gln Tyr Lys Gly Glu Lys Gly Ser Glu Gly Glu Pro Gly Ile Arg Gly 
        275                 280                 285             


Ile Ser Leu Lys Gly Glu Glu Gly Ile Met Gly Phe Pro Gly Leu Arg 
    290                 295                 300                 


Gly Tyr Pro Gly Leu Ser Gly Glu Lys Gly Ser Pro Gly Gln Lys Gly 
305                 310                 315                 320 


Ser Arg Gly Leu Asp Gly Tyr Gln Gly Pro Asp Gly Pro Arg Gly Pro 
                325                 330                 335     


Lys Gly Glu Ala Gly Asp Pro Gly Pro Pro Gly Leu Pro Ala Tyr Ser 
            340                 345                 350         


Pro His Pro Ser Leu Ala Lys Gly Ala Arg Gly Asp Pro Gly Phe Pro 
        355                 360                 365             


Gly Ala Gln Gly Glu Pro Gly Ser Gln Gly Glu Pro Gly Asp Pro Gly 
    370                 375                 380                 


Leu Pro Gly Pro Pro Gly Leu Ser Ile Gly Asp Gly Asp Gln Arg Arg 
385                 390                 395                 400 


Gly Leu Pro Gly Glu Met Gly Pro Lys Gly Phe Ile Gly Asp Pro Gly 
                405                 410                 415     


Ile Pro Ala Leu Tyr Gly Gly Pro Pro Gly Pro Asp Gly Lys Arg Gly 
            420                 425                 430         


Pro Pro Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro Asp Gly Phe 
        435                 440                 445             


Leu Phe Gly Leu Lys Gly Ala Lys Gly Arg Ala Gly Phe Pro Gly Leu 
    450                 455                 460                 


Pro Gly Ser Pro Gly Ala Arg Gly Pro Lys Gly Trp Lys Gly Asp Ala 
465                 470                 475                 480 


Gly Glu Cys Arg Cys Thr Glu Gly Asp Glu Ala Ile Lys Gly Leu Pro 
                485                 490                 495     


Gly Leu Pro Gly Pro Lys Gly Phe Ala Gly Ile Asn Gly Glu Pro Gly 
            500                 505                 510         


Arg Lys Gly Asp Arg Gly Asp Pro Gly Gln His Gly Leu Pro Gly Phe 
        515                 520                 525             


Pro Gly Leu Lys Gly Val Pro Gly Asn Ile Gly Ala Pro Gly Pro Lys 
    530                 535                 540                 


Gly Ala Lys Gly Asp Ser Arg Thr Ile Thr Thr Lys Gly Glu Arg Gly 
545                 550                 555                 560 


Gln Pro Gly Val Pro Gly Val Pro Gly Met Lys Gly Asp Asp Gly Ser 
                565                 570                 575     


Pro Gly Arg Asp Gly Leu Asp Gly Phe Pro Gly Leu Pro Gly Pro Pro 
            580                 585                 590         


Gly Asp Gly Ile Lys Gly Pro Pro Gly Asp Pro Gly Tyr Pro Gly Ile 
        595                 600                 605             


Pro Gly Thr Lys Gly Thr Pro Gly Glu Met Gly Pro Pro Gly Leu Gly 
    610                 615                 620                 


Leu Pro Gly Leu Lys Gly Gln Arg Gly Phe Pro Gly Asp Ala Gly Leu 
625                 630                 635                 640 


Pro Gly Pro Pro Gly Phe Leu Gly Pro Pro Gly Pro Ala Gly Thr Pro 
                645                 650                 655     


Gly Gln Ile Asp Cys Asp Thr Asp Val Lys Arg Ala Val Gly Gly Asp 
            660                 665                 670         


Arg Gln Glu Ala Ile Gln Pro Gly Cys Ile Gly Gly Pro Lys Gly Leu 
        675                 680                 685             


Pro Gly Leu Pro Gly Pro Pro Gly Pro Thr Gly Ala Lys Gly Leu Arg 
    690                 695                 700                 


Gly Ile Pro Gly Phe Ala Gly Ala Asp Gly Gly Pro Gly Pro Arg Gly 
705                 710                 715                 720 


Leu Pro Gly Asp Ala Gly Arg Glu Gly Phe Pro Gly Pro Pro Gly Phe 
                725                 730                 735     


Ile Gly Pro Arg Gly Ser Lys Gly Ala Val Gly Leu Pro Gly Pro Asp 
            740                 745                 750         


Gly Ser Pro Gly Pro Ile Gly Leu Pro Gly Pro Asp Gly Pro Pro Gly 
        755                 760                 765             


Glu Arg Gly Leu Pro Gly Glu Val Leu Gly Ala Gln Pro Gly Pro Arg 
    770                 775                 780                 


Gly Asp Ala Gly Val Pro Gly Gln Pro Gly Leu Lys Gly Leu Pro Gly 
785                 790                 795                 800 


Asp Arg Gly Pro Pro Gly Phe Arg Gly Ser Gln Gly Met Pro Gly Met 
                805                 810                 815     


Pro Gly Leu Lys Gly Gln Pro Gly Leu Pro Gly Pro Ser Gly Gln Pro 
            820                 825                 830         


Gly Leu Tyr Gly Pro Pro Gly Leu His Gly Phe Pro Gly Ala Pro Gly 
        835                 840                 845             


Gln Glu Gly Pro Leu Gly Leu Pro Gly Ile Pro Gly Arg Glu Gly Leu 
    850                 855                 860                 


Pro Gly Asp Arg Gly Asp Pro Gly Asp Thr Gly Ala Pro Gly Pro Val 
865                 870                 875                 880 


Gly Met Lys Gly Leu Ser Gly Asp Arg Gly Asp Ala Gly Phe Thr Gly 
                885                 890                 895     


Glu Gln Gly His Pro Gly Ser Pro Gly Phe Lys Gly Ile Asp Gly Met 
            900                 905                 910         


Pro Gly Thr Pro Gly Leu Lys Gly Asp Arg Gly Ser Pro Gly Met Asp 
        915                 920                 925             


Gly Phe Gln Gly Met Pro Gly Leu Lys Gly Arg Pro Gly Phe Pro Gly 
    930                 935                 940                 


Ser Lys Gly Glu Ala Gly Phe Phe Gly Ile Pro Gly Leu Lys Gly Leu 
945                 950                 955                 960 


Ala Gly Glu Pro Gly Phe Lys Gly Ser Arg Gly Asp Pro Gly Pro Pro 
                965                 970                 975     


Gly Pro Pro Pro Val Ile Leu Pro Gly Met Lys Asp Ile Lys Gly Glu 
            980                 985                 990         


Lys Gly Asp Glu Gly Pro Met Gly  Leu Lys Gly Tyr Leu  Gly Ala Lys 
        995                 1000                 1005             


Gly Ile  Gln Gly Met Pro Gly  Ile Pro Gly Leu Ser  Gly Ile Pro 
    1010                 1015                 1020             


Gly Leu  Pro Gly Arg Pro Gly  His Ile Lys Gly Val  Lys Gly Asp 
    1025                 1030                 1035             


Ile Gly  Val Pro Gly Ile Pro  Gly Leu Pro Gly Phe  Pro Gly Val 
    1040                 1045                 1050             


Ala Gly  Pro Pro Gly Ile Thr  Gly Phe Pro Gly Phe  Ile Gly Ser 
    1055                 1060                 1065             


Arg Gly  Asp Lys Gly Ala Pro  Gly Arg Ala Gly Leu  Tyr Gly Glu 
    1070                 1075                 1080             


Ile Gly  Ala Thr Gly Asp Phe  Gly Asp Ile Gly Asp  Thr Ile Asn 
    1085                 1090                 1095             


Leu Pro  Gly Arg Pro Gly Leu  Lys Gly Glu Arg Gly  Thr Thr Gly 
    1100                 1105                 1110             


Ile Pro  Gly Leu Lys Gly Phe  Phe Gly Glu Lys Gly  Thr Glu Gly 
    1115                 1120                 1125             


Asp Ile  Gly Phe Pro Gly Ile  Thr Gly Val Thr Gly  Val Gln Gly 
    1130                 1135                 1140             


Pro Pro  Gly Leu Lys Gly Gln  Thr Gly Phe Pro Gly  Leu Thr Gly 
    1145                 1150                 1155             


Pro Pro  Gly Ser Gln Gly Glu  Leu Gly Arg Ile Gly  Leu Pro Gly 
    1160                 1165                 1170             


Gly Lys  Gly Asp Asp Gly Trp  Pro Gly Ala Pro Gly  Leu Pro Gly 
    1175                 1180                 1185             


Phe Pro  Gly Leu Arg Gly Ile  Arg Gly Leu His Gly  Leu Pro Gly 
    1190                 1195                 1200             


Thr Lys  Gly Phe Pro Gly Ser  Pro Gly Ser Asp Ile  His Gly Asp 
    1205                 1210                 1215             


Pro Gly  Phe Pro Gly Pro Pro  Gly Glu Arg Gly Asp  Pro Gly Glu 
    1220                 1225                 1230             


Ala Asn  Thr Leu Pro Gly Pro  Val Gly Val Pro Gly  Gln Lys Gly 
    1235                 1240                 1245             


Asp Gln  Gly Ala Pro Gly Glu  Arg Gly Pro Pro Gly  Ser Pro Gly 
    1250                 1255                 1260             


Leu Gln  Gly Phe Pro Gly Ile  Thr Pro Pro Ser Asn  Ile Ser Gly 
    1265                 1270                 1275             


Ala Pro  Gly Asp Lys Gly Ala  Pro Gly Ile Phe Gly  Leu Lys Gly 
    1280                 1285                 1290             


Tyr Arg  Gly Pro Pro Gly Pro  Pro Gly Ser Ala Ala  Leu Pro Gly 
    1295                 1300                 1305             


Ser Lys  Gly Asp Thr Gly Asn  Pro Gly Ala Pro Gly  Thr Pro Gly 
    1310                 1315                 1320             


Thr Lys  Gly Trp Ala Gly Asp  Ser Gly Pro Gln Gly  Arg Pro Gly 
    1325                 1330                 1335             


Val Phe  Gly Leu Pro Gly Glu  Lys Gly Pro Arg Gly  Glu Gln Gly 
    1340                 1345                 1350             


Phe Met  Gly Asn Thr Gly Pro  Thr Gly Ala Val Gly  Asp Arg Gly 
    1355                 1360                 1365             


Pro Lys  Gly Pro Lys Gly Asp  Pro Gly Phe Pro Gly  Ala Pro Gly 
    1370                 1375                 1380             


Thr Val  Gly Ala Pro Gly Ile  Ala Gly Ile Pro Gln  Lys Ile Ala 
    1385                 1390                 1395             


Val Gln  Pro Gly Thr Val Gly  Pro Gln Gly Arg Arg  Gly Pro Pro 
    1400                 1405                 1410             


Gly Ala  Pro Gly Glu Met Gly  Pro Gln Gly Pro Pro  Gly Glu Pro 
    1415                 1420                 1425             


Gly Phe  Arg Gly Ala Pro Gly  Lys Ala Gly Pro Gln  Gly Arg Gly 
    1430                 1435                 1440             


Gly Val  Ser Ala Val Pro Gly  Phe Arg Gly Asp Glu  Gly Pro Ile 
    1445                 1450                 1455             


Gly His  Gln Gly Pro Ile Gly  Gln Glu Gly Ala Pro  Gly Arg Pro 
    1460                 1465                 1470             


Gly Ser  Pro Gly Leu Pro Gly  Met Pro Gly Arg Ser  Val Ser Ile 
    1475                 1480                 1485             


Gly Tyr  Leu Leu Val Lys His  Ser Gln Thr Asp Gln  Glu Pro Met 
    1490                 1495                 1500             


Cys Pro  Val Gly Met Asn Lys  Leu Trp Ser Gly Tyr  Ser Leu Leu 
    1505                 1510                 1515             


Tyr Phe  Glu Gly Gln Glu Lys  Ala His Asn Gln Asp  Leu Gly Leu 
    1520                 1525                 1530             


Ala Gly  Ser Cys Leu Ala Arg  Phe Ser Thr Met Pro  Phe Leu Tyr 
    1535                 1540                 1545             


Cys Asn  Pro Gly Asp Val Cys  Tyr Tyr Ala Ser Arg  Asn Asp Lys 
    1550                 1555                 1560             


Ser Tyr  Trp Leu Ser Thr Thr  Ala Pro Leu Pro Met  Met Pro Val 
    1565                 1570                 1575             


Ala Glu  Asp Glu Ile Lys Pro  Tyr Ile Ser Arg Cys  Ser Val Cys 
    1580                 1585                 1590             


Glu Ala  Pro Ala Ile Ala Ile  Ala Val His Ser Gln  Asp Val Ser 
    1595                 1600                 1605             


Ile Pro  His Cys Pro Ala Gly  Trp Arg Ser Leu Trp  Ile Gly Tyr 
    1610                 1615                 1620             


Ser Phe  Leu Met His Thr Ala  Ala Gly Asp Glu Gly  Gly Gly Gln 
    1625                 1630                 1635             


Ser Leu  Val Ser Pro Gly Ser  Cys Leu Glu Asp Phe  Arg Ala Thr 
    1640                 1645                 1650             


Pro Phe  Ile Glu Cys Asn Gly  Gly Arg Gly Thr Cys  His Tyr Tyr 
    1655                 1660                 1665             


Ala Asn  Lys Tyr Ser Phe Trp  Leu Thr Thr Ile Pro  Glu Gln Ser 
    1670                 1675                 1680             


Phe Gln  Gly Ser Pro Ser Ala  Asp Thr Leu Lys Ala  Gly Leu Ile 
    1685                 1690                 1695             


Arg Thr  His Ile Ser Arg Cys  Gln Val Cys Met Lys  Asn Leu 
    1700                 1705                 1710         


<210>  3295
<211>  42
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3295

Xaa Gly Asp Pro Gly Gln His Gly Leu Pro Gly Phe Pro Gly Leu Lys 
1               5                   10                  15      


Val Arg Ser Asn Phe Ile Met Lys Leu Ala Arg His Ser Glu Ala Ser 
            20                  25                  30          


Pro Gly Val Pro Phe Leu Pro Phe Ile Ser 
        35                  40          


<210>  3296
<211>  199
<212>  PRT
<213>  Homo Sapiens

<400>  3296

Ala Thr Trp Thr Thr Arg Gly Phe Val Phe Thr Arg His Ser Gln Thr 
1               5                   10                  15      


Thr Ala Ile Pro Ser Cys Pro Glu Gly Thr Val Pro Leu Tyr Ser Gly 
            20                  25                  30          


Phe Ser Phe Leu Phe Val Gln Gly Asn Gln Arg Ala His Gly Gln Asp 
        35                  40                  45              


Leu Gly Thr Leu Gly Ser Cys Leu Gln Arg Phe Thr Thr Met Pro Phe 
    50                  55                  60                  


Leu Phe Cys Asn Val Asn Asp Val Cys Asn Phe Ala Ser Arg Asn Asp 
65                  70                  75                  80  


Tyr Ser Tyr Trp Leu Ser Thr Pro Ala Leu Met Pro Met Asn Met Ala 
                85                  90                  95      


Pro Ile Thr Gly Arg Ala Leu Glu Pro Tyr Ile Ser Arg Cys Thr Val 
            100                 105                 110         


Cys Glu Gly Pro Ala Ile Ala Ile Ala Val His Ser Gln Thr Thr Asp 
        115                 120                 125             


Ile Pro Pro Cys Pro His Gly Trp Ile Ser Leu Trp Lys Gly Phe Ser 
    130                 135                 140                 


Phe Ile Met Lys Ala Tyr Ser Ile Asn Cys Glu Ser Trp Gly Ile Arg 
145                 150                 155                 160 


Lys Asn Asn Lys Ser Leu Ser Gly Val His Glu Glu Lys Thr Leu Lys 
                165                 170                 175     


Leu Lys Lys Thr Ala Glu Leu Leu Phe Phe Ile Leu Lys Asn Lys Val 
            180                 185                 190         


Met Thr Glu His Ala Val Ile 
        195                 


<210>  3297
<211>  156
<212>  PRT
<213>  Homo Sapiens

<400>  3297

Gly Asn Pro Gly Glu Lys Gly Asn Arg Gly Val Pro Gly Met Pro Gly 
1               5                   10                  15      


Leu Lys Gly Leu Lys Gly Leu Pro Gly Pro Ala Gly Pro Pro Gly Pro 
            20                  25                  30          


Arg Gly Asp Leu Gly Ser Thr Gly Asn Pro Gly Glu Pro Gly Leu Arg 
        35                  40                  45              


Gly Ile Pro Gly Ser Met Gly Asn Met Gly Met Pro Gly Ser Lys Gly 
    50                  55                  60                  


Lys Arg Gly Thr Leu Gly Phe Pro Gly Arg Ala Gly Arg Pro Gly Leu 
65                  70                  75                  80  


Pro Gly Ile His Gly Leu Gln Gly Asp Lys Gly Glu Pro Gly Tyr Ser 
                85                  90                  95      


Glu Gly Thr Arg Pro Gly Pro Pro Gly Pro Thr Gly Asp Pro Gly Leu 
            100                 105                 110         


Pro Gly Asp Met Gly Lys Lys Gly Glu Met Gly Gln Pro Gly Pro Pro 
        115                 120                 125             


Gly His Leu Gly Pro Ala Gly Pro Glu Gly Ala Pro Gly Ser Pro Gly 
    130                 135                 140                 


Ser Pro Gly Leu Pro Val Pro Ala Ala Pro Ser Leu 
145                 150                 155     


<210>  3298
<211>  1670
<212>  PRT
<213>  Homo Sapiens

<400>  3298

Met Ser Ala Arg Thr Ala Pro Arg Pro Gln Val Leu Leu Leu Pro Leu 
1               5                   10                  15      


Leu Leu Val Leu Leu Ala Ala Ala Pro Ala Ala Ser Lys Gly Cys Val 
            20                  25                  30          


Cys Lys Asp Lys Gly Gln Cys Phe Cys Asp Gly Ala Lys Gly Glu Lys 
        35                  40                  45              


Gly Glu Lys Gly Phe Pro Gly Pro Pro Gly Ser Pro Gly Gln Lys Gly 
    50                  55                  60                  


Phe Thr Gly Pro Glu Gly Leu Pro Gly Pro Gln Gly Pro Lys Gly Phe 
65                  70                  75                  80  


Pro Gly Leu Pro Gly Leu Thr Gly Ser Lys Gly Val Arg Gly Ile Ser 
                85                  90                  95      


Gly Leu Pro Gly Phe Ser Gly Ser Pro Gly Leu Pro Gly Thr Pro Gly 
            100                 105                 110         


Asn Thr Gly Pro Tyr Gly Leu Val Gly Val Pro Gly Cys Ser Gly Ser 
        115                 120                 125             


Lys Gly Glu Gln Gly Phe Pro Gly Leu Pro Gly Thr Leu Gly Tyr Pro 
    130                 135                 140                 


Gly Ile Pro Gly Ala Ala Gly Leu Lys Gly Gln Lys Gly Ala Pro Ala 
145                 150                 155                 160 


Lys Glu Glu Asp Ile Glu Leu Asp Ala Lys Gly Asp Pro Gly Leu Pro 
                165                 170                 175     


Gly Ala Pro Gly Pro Gln Gly Leu Pro Gly Pro Pro Gly Phe Pro Gly 
            180                 185                 190         


Pro Val Gly Pro Pro Gly Pro Pro Gly Phe Phe Gly Phe Pro Gly Ala 
        195                 200                 205             


Met Gly Pro Arg Gly Pro Lys Gly His Met Gly Glu Arg Val Ile Gly 
    210                 215                 220                 


His Lys Gly Glu Arg Gly Val Lys Gly Leu Thr Gly Pro Pro Gly Pro 
225                 230                 235                 240 


Pro Gly Thr Val Ile Val Thr Leu Thr Gly Pro Asp Asn Arg Thr Asp 
                245                 250                 255     


Leu Lys Gly Glu Lys Gly Asp Lys Gly Ala Met Gly Glu Pro Gly Pro 
            260                 265                 270         


Pro Gly Pro Ser Gly Leu Pro Gly Glu Ser Tyr Gly Ser Glu Lys Gly 
        275                 280                 285             


Ala Pro Gly Asp Pro Gly Leu Gln Gly Lys Pro Gly Lys Asp Gly Val 
    290                 295                 300                 


Pro Gly Phe Pro Gly Ser Glu Gly Val Lys Gly Asn Arg Gly Phe Pro 
305                 310                 315                 320 


Gly Leu Met Gly Glu Asp Gly Ile Lys Gly Gln Lys Gly Asp Ile Gly 
                325                 330                 335     


Pro Pro Gly Phe Arg Gly Pro Thr Glu Tyr Tyr Asp Thr Tyr Gln Glu 
            340                 345                 350         


Lys Gly Asp Glu Gly Thr Pro Gly Pro Pro Gly Pro Arg Gly Ala Arg 
        355                 360                 365             


Gly Pro Gln Gly Pro Ser Gly Pro Pro Gly Val Pro Gly Ser Pro Gly 
    370                 375                 380                 


Ser Ser Arg Pro Gly Leu Arg Gly Ala Pro Gly Trp Pro Gly Leu Lys 
385                 390                 395                 400 


Gly Ser Lys Gly Glu Arg Gly Arg Pro Gly Lys Asp Ala Met Gly Thr 
                405                 410                 415     


Pro Gly Ser Pro Gly Cys Ala Gly Ser Pro Gly Leu Pro Gly Ser Pro 
            420                 425                 430         


Gly Pro Pro Gly Pro Pro Gly Asp Ile Val Phe Arg Lys Gly Pro Pro 
        435                 440                 445             


Gly Asp His Gly Leu Pro Gly Tyr Leu Gly Ser Pro Gly Ile Pro Gly 
    450                 455                 460                 


Val Asp Gly Pro Lys Gly Glu Pro Gly Leu Leu Cys Thr Gln Cys Pro 
465                 470                 475                 480 


Tyr Ile Pro Gly Pro Pro Gly Leu Pro Gly Leu Pro Gly Leu His Gly 
                485                 490                 495     


Val Lys Gly Ile Pro Gly Arg Gln Gly Ala Ala Gly Leu Lys Gly Ser 
            500                 505                 510         


Pro Gly Ser Pro Gly Asn Thr Gly Leu Pro Gly Phe Pro Gly Phe Pro 
        515                 520                 525             


Gly Ala Gln Gly Asp Pro Gly Leu Lys Gly Glu Lys Gly Glu Thr Leu 
    530                 535                 540                 


Gln Pro Glu Gly Gln Val Gly Val Pro Gly Asp Pro Gly Leu Arg Gly 
545                 550                 555                 560 


Gln Pro Gly Arg Lys Gly Leu Asp Gly Ile Pro Gly Thr Pro Gly Val 
                565                 570                 575     


Lys Gly Leu Pro Gly Pro Lys Gly Glu Leu Ala Leu Ser Gly Glu Lys 
            580                 585                 590         


Gly Asp Gln Gly Pro Pro Gly Asp Pro Gly Ser Pro Gly Ser Pro Gly 
        595                 600                 605             


Pro Ala Gly Pro Ala Gly Pro Pro Gly Tyr Gly Pro Gln Gly Glu Pro 
    610                 615                 620                 


Gly Leu Gln Gly Thr Gln Gly Val Pro Gly Ala Pro Gly Pro Pro Gly 
625                 630                 635                 640 


Glu Ala Gly Pro Arg Gly Glu Leu Ser Val Ser Thr Pro Val Pro Gly 
                645                 650                 655     


Pro Pro Gly Pro Pro Gly Pro Pro Gly His Pro Gly Pro Gln Gly Pro 
            660                 665                 670         


Pro Gly Ile Pro Gly Ser Leu Gly Lys Cys Gly Asp Pro Gly Leu Pro 
        675                 680                 685             


Gly Pro Asp Gly Glu Pro Gly Ile Pro Gly Ile Gly Phe Pro Gly Pro 
    690                 695                 700                 


Pro Gly Pro Lys Gly Asp Gln Gly Phe Pro Gly Thr Lys Gly Ser Leu 
705                 710                 715                 720 


Gly Cys Pro Gly Lys Met Gly Glu Pro Gly Leu Pro Gly Lys Pro Gly 
                725                 730                 735     


Leu Pro Gly Ala Lys Gly Glu Pro Ala Val Ala Met Pro Gly Gly Pro 
            740                 745                 750         


Gly Thr Pro Gly Phe Pro Gly Glu Arg Gly Asn Ser Gly Glu His Gly 
        755                 760                 765             


Glu Ile Gly Leu Pro Gly Leu Pro Gly Leu Pro Gly Thr Pro Gly Asn 
    770                 775                 780                 


Glu Gly Leu Asp Gly Pro Arg Gly Asp Pro Gly Gln Pro Gly Pro Pro 
785                 790                 795                 800 


Gly Glu Gln Gly Pro Pro Gly Arg Cys Ile Glu Gly Pro Arg Gly Ala 
                805                 810                 815     


Gln Gly Leu Pro Gly Leu Asn Gly Leu Lys Gly Gln Gln Gly Arg Arg 
            820                 825                 830         


Gly Lys Thr Gly Pro Lys Gly Asp Pro Gly Ile Pro Gly Leu Asp Arg 
        835                 840                 845             


Ser Gly Phe Pro Gly Glu Thr Gly Ser Pro Gly Ile Pro Gly His Gln 
    850                 855                 860                 


Gly Glu Met Gly Pro Leu Gly Gln Arg Gly Tyr Pro Gly Asn Pro Gly 
865                 870                 875                 880 


Ile Leu Gly Pro Pro Gly Glu Asp Gly Val Ile Gly Met Met Gly Phe 
                885                 890                 895     


Pro Gly Ala Ile Gly Pro Pro Gly Pro Pro Gly Asn Pro Gly Thr Pro 
            900                 905                 910         


Gly Gln Arg Gly Ser Pro Gly Ile Pro Gly Val Lys Gly Gln Arg Gly 
        915                 920                 925             


Thr Pro Gly Ala Lys Gly Glu Gln Gly Asp Lys Gly Asn Pro Gly Pro 
    930                 935                 940                 


Ser Glu Ile Ser His Val Ile Gly Asp Lys Gly Glu Pro Gly Leu Lys 
945                 950                 955                 960 


Gly Phe Ala Gly Asn Pro Gly Glu Lys Gly Asn Arg Gly Val Pro Gly 
                965                 970                 975     


Met Pro Gly Leu Lys Gly Leu Lys Gly Leu Pro Gly Pro Ala Gly Pro 
            980                 985                 990         


Pro Gly Pro Arg Gly Asp Leu Gly  Ser Thr Gly Asn Pro  Gly Glu Pro 
        995                 1000                 1005             


Gly Leu  Arg Gly Ile Pro Gly  Ser Met Gly Asn Met  Gly Met Pro 
    1010                 1015                 1020             


Gly Ser  Lys Gly Lys Arg Gly  Thr Leu Gly Phe Pro  Gly Arg Ala 
    1025                 1030                 1035             


Gly Arg  Pro Gly Leu Pro Gly  Ile His Gly Leu Gln  Gly Asp Lys 
    1040                 1045                 1050             


Gly Glu  Pro Gly Tyr Ser Glu  Gly Thr Arg Pro Gly  Pro Pro Gly 
    1055                 1060                 1065             


Pro Thr  Gly Asp Pro Gly Leu  Pro Gly Asp Met Gly  Lys Lys Gly 
    1070                 1075                 1080             


Glu Met  Gly Gln Pro Gly Pro  Pro Gly His Leu Gly  Pro Ala Gly 
    1085                 1090                 1095             


Pro Glu  Gly Ala Pro Gly Ser  Pro Gly Ser Pro Gly  Leu Pro Gly 
    1100                 1105                 1110             


Lys Pro  Gly Pro His Gly Asp  Leu Gly Phe Lys Gly  Ile Lys Gly 
    1115                 1120                 1125             


Leu Leu  Gly Pro Pro Gly Ile  Arg Gly Pro Pro Gly  Leu Pro Gly 
    1130                 1135                 1140             


Phe Pro  Gly Ser Pro Gly Pro  Met Gly Ile Arg Gly  Asp Gln Gly 
    1145                 1150                 1155             


Arg Asp  Gly Ile Pro Gly Pro  Ala Gly Glu Lys Gly  Glu Thr Gly 
    1160                 1165                 1170             


Leu Leu  Arg Ala Pro Pro Gly  Pro Arg Gly Asn Pro  Gly Ala Gln 
    1175                 1180                 1185             


Gly Ala  Lys Gly Asp Arg Gly  Ala Pro Gly Phe Pro  Gly Leu Pro 
    1190                 1195                 1200             


Gly Arg  Lys Gly Ala Met Gly  Asp Ala Gly Pro Arg  Gly Pro Thr 
    1205                 1210                 1215             


Gly Ile  Glu Gly Phe Pro Gly  Pro Pro Gly Leu Pro  Gly Ala Ile 
    1220                 1225                 1230             


Ile Pro  Gly Gln Thr Gly Asn  Arg Gly Pro Pro Gly  Ser Arg Gly 
    1235                 1240                 1245             


Ser Pro  Gly Ala Pro Gly Pro  Pro Gly Pro Pro Gly  Ser His Val 
    1250                 1255                 1260             


Ile Gly  Ile Lys Gly Asp Lys  Gly Ser Met Gly His  Pro Gly Pro 
    1265                 1270                 1275             


Lys Gly  Pro Pro Gly Thr Ala  Gly Asp Met Gly Pro  Pro Gly Arg 
    1280                 1285                 1290             


Leu Gly  Ala Pro Gly Thr Pro  Gly Leu Pro Gly Pro  Arg Gly Asp 
    1295                 1300                 1305             


Pro Gly  Phe Gln Gly Phe Pro  Gly Val Lys Gly Glu  Lys Gly Asn 
    1310                 1315                 1320             


Pro Gly  Phe Leu Gly Ser Ile  Gly Pro Pro Gly Pro  Ile Gly Pro 
    1325                 1330                 1335             


Lys Gly  Pro Pro Gly Val Arg  Gly Asp Pro Gly Thr  Leu Lys Ile 
    1340                 1345                 1350             


Ile Ser  Leu Pro Gly Ser Pro  Gly Pro Pro Gly Thr  Pro Gly Glu 
    1355                 1360                 1365             


Pro Gly  Met Gln Gly Glu Pro  Gly Pro Pro Gly Pro  Pro Gly Asn 
    1370                 1375                 1380             


Leu Gly  Pro Cys Gly Pro Arg  Gly Lys Pro Gly Lys  Asp Gly Lys 
    1385                 1390                 1395             


Pro Gly  Thr Pro Gly Pro Ala  Gly Glu Lys Gly Asn  Lys Gly Ser 
    1400                 1405                 1410             


Lys Gly  Glu Pro Gly Pro Ala  Gly Ser Asp Gly Leu  Pro Gly Leu 
    1415                 1420                 1425             


Lys Gly  Lys Arg Gly Asp Ser  Gly Ser Pro Ala Thr  Trp Thr Thr 
    1430                 1435                 1440             


Arg Gly  Phe Val Phe Thr Arg  His Ser Gln Thr Thr  Ala Ile Pro 
    1445                 1450                 1455             


Ser Cys  Pro Glu Gly Thr Val  Pro Leu Tyr Ser Gly  Phe Ser Phe 
    1460                 1465                 1470             


Leu Phe  Val Gln Gly Asn Gln  Arg Ala His Gly Gln  Asp Leu Gly 
    1475                 1480                 1485             


Thr Leu  Gly Ser Cys Leu Gln  Arg Phe Thr Thr Met  Pro Phe Leu 
    1490                 1495                 1500             


Phe Cys  Asn Val Asn Asp Val  Cys Asn Phe Ala Ser  Arg Asn Asp 
    1505                 1510                 1515             


Tyr Ser  Tyr Trp Leu Ser Thr  Pro Ala Leu Met Pro  Met Asn Met 
    1520                 1525                 1530             


Ala Pro  Ile Thr Gly Arg Ala  Leu Glu Pro Tyr Ile  Ser Arg Cys 
    1535                 1540                 1545             


Thr Val  Cys Glu Gly Pro Ala  Ile Ala Ile Ala Val  His Ser Gln 
    1550                 1555                 1560             


Thr Thr  Asp Ile Pro Pro Cys  Pro His Gly Trp Ile  Ser Leu Trp 
    1565                 1570                 1575             


Lys Gly  Phe Ser Phe Ile Met  Phe Thr Ser Ala Gly  Ser Glu Gly 
    1580                 1585                 1590             


Thr Gly  Gln Ala Leu Ala Ser  Pro Gly Ser Cys Leu  Glu Glu Phe 
    1595                 1600                 1605             


Arg Ala  Ser Pro Phe Leu Glu  Cys His Gly Arg Gly  Thr Cys Asn 
    1610                 1615                 1620             


Tyr Tyr  Ser Asn Ser Tyr Ser  Phe Trp Leu Ala Ser  Leu Asn Pro 
    1625                 1630                 1635             


Glu Arg  Met Phe Arg Lys Pro  Ile Pro Ser Thr Val  Lys Ala Gly 
    1640                 1645                 1650             


Glu Leu  Glu Lys Ile Ile Ser  Arg Cys Gln Val Cys  Met Lys Lys 
    1655                 1660                 1665             


Arg His  
    1670 


<210>  3299
<211>  155
<212>  PRT
<213>  Homo Sapiens

<400>  3299

Val Arg Gly Asp Pro Gly Thr Leu Lys Ile Ile Ser Leu Pro Gly Ser 
1               5                   10                  15      


Pro Gly Pro Pro Gly Thr Pro Gly Glu Pro Gly Met Gln Gly Glu Pro 
            20                  25                  30          


Gly Pro Pro Gly Pro Pro Gly Asn Leu Gly Pro Cys Gly Pro Arg Gly 
        35                  40                  45              


Lys Pro Gly Lys Asp Gly Lys Pro Gly Thr Pro Gly Pro Ala Gly Glu 
    50                  55                  60                  


Lys Gly Asn Lys Gly Ser Lys Gly Glu Pro Gly Pro Ala Gly Ser Asp 
65                  70                  75                  80  


Gly Leu Pro Gly Leu Lys Gly Lys Arg Gly Asp Ser Gly Ser Pro Ala 
                85                  90                  95      


Thr Trp Thr Thr Arg Gly Phe Val Phe Thr Arg His Ser Gln Thr Thr 
            100                 105                 110         


Ala Ile Pro Ser Cys Pro Glu Gly Thr Val Pro Leu Tyr Ser Gly Phe 
        115                 120                 125             


Ser Phe Leu Phe Val Gln Gly Asn Gln Arg Ala His Gly Gln Asp Leu 
    130                 135                 140                 


Asp Ala Leu Phe Val Lys Val Leu Arg Ser Pro 
145                 150                 155 


<210>  3300
<211>  1690
<212>  PRT
<213>  Homo Sapiens

<400>  3300

Met Trp Ser Leu His Ile Val Leu Met Arg Cys Ser Phe Arg Leu Thr 
1               5                   10                  15      


Lys Ser Leu Ala Thr Gly Pro Trp Ser Leu Ile Leu Ile Leu Phe Ser 
            20                  25                  30          


Val Gln Tyr Val Tyr Gly Ser Gly Lys Lys Tyr Ile Gly Pro Cys Gly 
        35                  40                  45              


Gly Arg Asp Cys Ser Val Cys His Cys Val Pro Glu Lys Gly Ser Arg 
    50                  55                  60                  


Gly Pro Pro Gly Pro Pro Gly Pro Gln Gly Pro Ile Gly Pro Leu Gly 
65                  70                  75                  80  


Ala Pro Gly Pro Ile Gly Leu Ser Gly Glu Lys Gly Met Arg Gly Asp 
                85                  90                  95      


Arg Gly Pro Pro Gly Ala Ala Gly Asp Lys Gly Asp Lys Gly Pro Thr 
            100                 105                 110         


Gly Val Pro Gly Phe Pro Gly Leu Asp Gly Ile Pro Gly His Pro Gly 
        115                 120                 125             


Pro Pro Gly Pro Arg Gly Lys Pro Gly Met Ser Gly His Asn Gly Ser 
    130                 135                 140                 


Arg Gly Asp Pro Gly Phe Pro Gly Gly Arg Gly Ala Leu Gly Pro Gly 
145                 150                 155                 160 


Gly Pro Leu Gly His Pro Gly Glu Lys Gly Glu Lys Gly Asn Ser Val 
                165                 170                 175     


Phe Ile Leu Gly Ala Val Lys Gly Ile Gln Gly Asp Arg Gly Asp Pro 
            180                 185                 190         


Gly Leu Pro Gly Leu Pro Gly Ser Trp Gly Ala Gly Gly Pro Ala Gly 
        195                 200                 205             


Pro Thr Gly Tyr Pro Gly Glu Pro Gly Leu Val Gly Pro Pro Gly Gln 
    210                 215                 220                 


Pro Gly Arg Pro Gly Leu Lys Gly Asn Pro Gly Val Gly Val Lys Gly 
225                 230                 235                 240 


Gln Met Gly Asp Pro Gly Glu Val Gly Gln Gln Gly Ser Pro Gly Pro 
                245                 250                 255     


Thr Leu Leu Val Glu Pro Pro Asp Phe Cys Leu Tyr Lys Gly Glu Lys 
            260                 265                 270         


Gly Ile Lys Gly Ile Pro Gly Met Val Gly Leu Pro Gly Pro Pro Gly 
        275                 280                 285             


Arg Lys Gly Glu Ser Gly Ile Gly Ala Lys Gly Glu Lys Gly Ile Pro 
    290                 295                 300                 


Gly Phe Pro Gly Pro Arg Gly Asp Pro Gly Ser Tyr Gly Ser Pro Gly 
305                 310                 315                 320 


Phe Pro Gly Leu Lys Gly Glu Leu Gly Leu Val Gly Asp Pro Gly Leu 
                325                 330                 335     


Phe Gly Leu Ile Gly Pro Lys Gly Asp Pro Gly Asn Arg Gly His Pro 
            340                 345                 350         


Gly Pro Pro Gly Val Leu Val Thr Pro Pro Leu Pro Leu Lys Gly Pro 
        355                 360                 365             


Pro Gly Asp Pro Gly Phe Pro Gly Arg Tyr Gly Glu Thr Gly Asp Val 
    370                 375                 380                 


Gly Pro Pro Gly Pro Pro Gly Leu Leu Gly Arg Pro Gly Glu Ala Cys 
385                 390                 395                 400 


Ala Gly Met Ile Gly Pro Pro Gly Pro Gln Gly Phe Pro Gly Leu Pro 
                405                 410                 415     


Gly Leu Pro Gly Glu Ala Gly Ile Pro Gly Arg Pro Asp Ser Ala Pro 
            420                 425                 430         


Gly Lys Pro Gly Lys Pro Gly Ser Pro Gly Leu Pro Gly Ala Pro Gly 
        435                 440                 445             


Leu Gln Gly Leu Pro Gly Ser Ser Val Ile Tyr Cys Ser Val Gly Asn 
    450                 455                 460                 


Pro Gly Pro Gln Gly Ile Lys Gly Lys Val Gly Pro Pro Gly Gly Arg 
465                 470                 475                 480 


Gly Pro Lys Gly Glu Lys Gly Asn Glu Gly Leu Cys Ala Cys Glu Pro 
                485                 490                 495     


Gly Pro Met Gly Pro Pro Gly Pro Pro Gly Leu Pro Gly Arg Gln Gly 
            500                 505                 510         


Ser Lys Gly Asp Leu Gly Leu Pro Gly Trp Leu Gly Thr Lys Gly Asp 
        515                 520                 525             


Pro Gly Pro Pro Gly Ala Glu Gly Pro Pro Gly Leu Pro Gly Lys His 
    530                 535                 540                 


Gly Ala Ser Gly Pro Pro Gly Asn Lys Gly Ala Lys Gly Asp Met Val 
545                 550                 555                 560 


Val Ser Arg Val Lys Gly His Lys Gly Glu Arg Gly Pro Asp Gly Pro 
                565                 570                 575     


Pro Gly Phe Pro Gly Gln Pro Gly Ser His Gly Arg Asp Gly His Ala 
            580                 585                 590         


Gly Glu Lys Gly Asp Pro Gly Pro Pro Gly Asp His Glu Asp Ala Thr 
        595                 600                 605             


Pro Gly Gly Lys Gly Phe Pro Gly Pro Leu Gly Pro Pro Gly Lys Ala 
    610                 615                 620                 


Gly Pro Val Gly Pro Pro Gly Leu Gly Phe Pro Gly Pro Pro Gly Glu 
625                 630                 635                 640 


Arg Gly His Pro Gly Val Pro Gly His Pro Gly Val Arg Gly Pro Asp 
                645                 650                 655     


Gly Leu Lys Gly Gln Lys Gly Asp Thr Ile Ser Cys Asn Val Thr Tyr 
            660                 665                 670         


Pro Gly Arg His Gly Pro Pro Gly Phe Asp Gly Pro Pro Gly Pro Lys 
        675                 680                 685             


Gly Phe Pro Gly Pro Gln Gly Ala Pro Gly Leu Ser Gly Ser Asp Gly 
    690                 695                 700                 


His Lys Gly Arg Pro Gly Thr Pro Gly Thr Ala Glu Ile Pro Gly Pro 
705                 710                 715                 720 


Pro Gly Phe Arg Gly Asp Met Gly Asp Pro Gly Phe Gly Gly Glu Lys 
                725                 730                 735     


Gly Ser Ser Pro Val Gly Pro Pro Gly Pro Pro Gly Ser Pro Gly Val 
            740                 745                 750         


Asn Gly Gln Lys Gly Ile Pro Gly Asp Pro Ala Phe Gly His Leu Gly 
        755                 760                 765             


Pro Pro Gly Lys Arg Gly Leu Ser Gly Val Pro Gly Ile Lys Gly Pro 
    770                 775                 780                 


Arg Gly Asp Pro Gly Cys Pro Gly Ala Glu Gly Pro Ala Gly Ile Pro 
785                 790                 795                 800 


Gly Phe Leu Gly Leu Lys Gly Pro Lys Gly Arg Glu Gly His Ala Gly 
                805                 810                 815     


Phe Pro Gly Val Pro Gly Pro Pro Gly His Ser Cys Glu Arg Gly Ala 
            820                 825                 830         


Pro Gly Ile Pro Gly Gln Pro Gly Leu Pro Gly Tyr Pro Gly Ser Pro 
        835                 840                 845             


Gly Ala Pro Gly Gly Lys Gly Gln Pro Gly Asp Val Gly Pro Pro Gly 
    850                 855                 860                 


Pro Ala Gly Met Lys Gly Leu Pro Gly Leu Pro Gly Arg Pro Gly Ala 
865                 870                 875                 880 


His Gly Pro Pro Gly Leu Pro Gly Ile Pro Gly Pro Phe Gly Asp Asp 
                885                 890                 895     


Gly Leu Pro Gly Pro Pro Gly Pro Lys Gly Pro Arg Gly Leu Pro Gly 
            900                 905                 910         


Phe Pro Gly Phe Pro Gly Glu Arg Gly Lys Pro Gly Ala Glu Gly Cys 
        915                 920                 925             


Pro Gly Ala Lys Gly Glu Pro Gly Glu Lys Gly Met Ser Gly Leu Pro 
    930                 935                 940                 


Gly Asp Arg Gly Leu Arg Gly Ala Lys Gly Ala Ile Gly Pro Pro Gly 
945                 950                 955                 960 


Asp Glu Gly Glu Met Ala Ile Ile Ser Gln Lys Gly Thr Pro Gly Glu 
                965                 970                 975     


Pro Gly Pro Pro Gly Asp Asp Gly Phe Pro Gly Glu Arg Gly Asp Lys 
            980                 985                 990         


Gly Thr Pro Gly Met Gln Gly Arg  Arg Gly Glu Pro Gly  Arg Tyr Gly 
        995                 1000                 1005             


Pro Pro  Gly Phe His Arg Gly  Glu Pro Gly Glu Lys  Gly Gln Pro 
    1010                 1015                 1020             


Gly Pro  Pro Gly Pro Pro Gly  Pro Pro Gly Ser Thr  Gly Leu Arg 
    1025                 1030                 1035             


Gly Phe  Ile Gly Phe Pro Gly  Leu Pro Gly Asp Gln  Gly Glu Pro 
    1040                 1045                 1050             


Gly Ser  Pro Gly Pro Pro Gly  Phe Ser Gly Ile Asp  Gly Ala Arg 
    1055                 1060                 1065             


Gly Pro  Lys Gly Asn Lys Gly  Asp Pro Ala Ser His  Phe Gly Pro 
    1070                 1075                 1080             


Pro Gly  Pro Lys Gly Glu Pro  Gly Ser Pro Gly Cys  Pro Gly His 
    1085                 1090                 1095             


Phe Gly  Ala Ser Gly Glu Gln  Gly Leu Pro Gly Ile  Gln Gly Pro 
    1100                 1105                 1110             


Arg Gly  Ser Pro Gly Arg Pro  Gly Pro Pro Gly Ser  Ser Gly Pro 
    1115                 1120                 1125             


Pro Gly  Cys Pro Gly Asp His  Gly Met Pro Gly Leu  Arg Gly Gln 
    1130                 1135                 1140             


Pro Gly  Glu Met Gly Asp Pro  Gly Pro Arg Gly Leu  Gln Gly Asp 
    1145                 1150                 1155             


Pro Gly  Ile Pro Gly Pro Pro  Gly Ile Lys Gly Pro  Ser Gly Ser 
    1160                 1165                 1170             


Pro Gly  Leu Asn Gly Leu His  Gly Leu Lys Gly Gln  Lys Gly Thr 
    1175                 1180                 1185             


Lys Gly  Ala Ser Gly Leu His  Asp Val Gly Pro Pro  Gly Pro Val 
    1190                 1195                 1200             


Gly Ile  Pro Gly Leu Lys Gly  Glu Arg Gly Asp Pro  Gly Ser Pro 
    1205                 1210                 1215             


Gly Ile  Ser Pro Pro Gly Pro  Arg Gly Lys Lys Gly  Pro Pro Gly 
    1220                 1225                 1230             


Pro Pro  Gly Ser Ser Gly Pro  Pro Gly Pro Ala Gly  Ala Thr Gly 
    1235                 1240                 1245             


Arg Ala  Pro Lys Asp Ile Pro  Asp Pro Gly Pro Pro  Gly Asp Gln 
    1250                 1255                 1260             


Gly Pro  Pro Gly Pro Asp Gly  Pro Arg Gly Ala Pro  Gly Pro Pro 
    1265                 1270                 1275             


Gly Leu  Pro Gly Ser Val Asp  Leu Leu Arg Gly Glu  Pro Gly Asp 
    1280                 1285                 1290             


Cys Gly  Leu Pro Gly Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Pro 
    1295                 1300                 1305             


Pro Gly  Tyr Lys Gly Phe Pro  Gly Cys Asp Gly Lys  Asp Gly Gln 
    1310                 1315                 1320             


Lys Gly  Pro Val Gly Phe Pro  Gly Pro Gln Gly Pro  His Gly Phe 
    1325                 1330                 1335             


Pro Gly  Pro Pro Gly Glu Lys  Gly Leu Pro Gly Pro  Pro Gly Arg 
    1340                 1345                 1350             


Lys Gly  Pro Thr Gly Leu Pro  Gly Pro Arg Gly Glu  Pro Gly Pro 
    1355                 1360                 1365             


Pro Ala  Asp Val Asp Asp Cys  Pro Arg Ile Pro Gly  Leu Pro Gly 
    1370                 1375                 1380             


Ala Pro  Gly Met Arg Gly Pro  Glu Gly Ala Met Gly  Leu Pro Gly 
    1385                 1390                 1395             


Met Arg  Gly Pro Ser Gly Pro  Gly Cys Lys Gly Glu  Pro Gly Leu 
    1400                 1405                 1410             


Asp Gly  Arg Arg Gly Val Asp  Gly Val Pro Gly Ser  Pro Gly Pro 
    1415                 1420                 1425             


Pro Gly  Arg Lys Gly Asp Thr  Gly Glu Asp Gly Tyr  Pro Gly Gly 
    1430                 1435                 1440             


Pro Gly  Pro Pro Gly Pro Ile  Gly Asp Pro Gly Pro  Lys Gly Phe 
    1445                 1450                 1455             


Gly Pro  Gly Tyr Leu Gly Gly  Phe Leu Leu Val Leu  His Ser Gln 
    1460                 1465                 1470             


Thr Asp  Gln Glu Pro Thr Cys  Pro Leu Gly Met Pro  Arg Leu Trp 
    1475                 1480                 1485             


Thr Gly  Tyr Ser Leu Leu Tyr  Leu Glu Gly Gln Glu  Lys Ala His 
    1490                 1495                 1500             


Asn Gln  Asp Leu Gly Leu Ala  Gly Ser Cys Leu Pro  Val Phe Ser 
    1505                 1510                 1515             


Thr Leu  Pro Phe Ala Tyr Cys  Asn Ile His Gln Val  Cys His Tyr 
    1520                 1525                 1530             


Ala Gln  Arg Asn Asp Arg Ser  Tyr Trp Leu Ala Ser  Ala Ala Pro 
    1535                 1540                 1545             


Leu Pro  Met Met Pro Leu Ser  Glu Glu Ala Ile Arg  Pro Tyr Val 
    1550                 1555                 1560             


Ser Arg  Cys Ala Val Cys Glu  Ala Pro Ala Gln Ala  Val Ala Val 
    1565                 1570                 1575             


His Ser  Gln Asp Gln Ser Ile  Pro Pro Cys Pro Gln  Thr Trp Arg 
    1580                 1585                 1590             


Ser Leu  Trp Ile Gly Tyr Ser  Phe Leu Met His Thr  Gly Ala Gly 
    1595                 1600                 1605             


Asp Gln  Gly Gly Gly Gln Ala  Leu Met Ser Pro Gly  Ser Cys Leu 
    1610                 1615                 1620             


Glu Asp  Phe Arg Ala Ala Pro  Phe Leu Glu Cys Gln  Gly Arg Gln 
    1625                 1630                 1635             


Gly Thr  Cys His Phe Phe Ala  Asn Lys Tyr Ser Phe  Trp Leu Thr 
    1640                 1645                 1650             


Thr Val  Lys Ala Asp Leu Gln  Phe Ser Ser Ala Pro  Ala Pro Asp 
    1655                 1660                 1665             


Thr Leu  Lys Glu Ser Gln Ala  Gln Arg Gln Lys Ile  Ser Arg Cys 
    1670                 1675                 1680             


Gln Val  Cys Val Lys Tyr Ser  
    1685                 1690 


<210>  3301
<211>  296
<212>  PRT
<213>  Homo Sapiens

<400>  3301

Met Trp Ser Leu His Ile Val Leu Met Arg Cys Ser Phe Arg Leu Thr 
1               5                   10                  15      


Lys Ser Leu Ala Thr Gly Pro Trp Ser Leu Ile Leu Ile Leu Phe Ser 
            20                  25                  30          


Val Gln Tyr Val Tyr Gly Ser Gly Lys Lys Tyr Ile Gly Pro Cys Gly 
        35                  40                  45              


Gly Arg Asp Cys Ser Val Cys His Cys Val Pro Glu Lys Gly Ser Arg 
    50                  55                  60                  


Gly Pro Pro Gly Pro Pro Gly Pro Gln Gly Pro Ile Gly Pro Leu Gly 
65                  70                  75                  80  


Ala Pro Gly Pro Ile Gly Leu Ser Gly Glu Lys Gly Met Arg Gly Asp 
                85                  90                  95      


Arg Gly Pro Pro Gly Ala Ala Gly Asp Lys Gly Asp Lys Gly Pro Thr 
            100                 105                 110         


Gly Val Pro Gly Phe Pro Gly Leu Asp Gly Ile Pro Gly His Pro Gly 
        115                 120                 125             


Pro Pro Gly Pro Arg Gly Lys Pro Gly Met Ser Gly His Asn Gly Ser 
    130                 135                 140                 


Arg Gly Asp Pro Gly Phe Pro Gly Gly Arg Gly Ala Leu Gly Pro Gly 
145                 150                 155                 160 


Gly Pro Leu Gly His Pro Gly Glu Lys Gly Glu Lys Gly Asn Ser Val 
                165                 170                 175     


Phe Ile Leu Gly Ala Val Lys Gly Ile Gln Gly Asp Arg Gly Asp Pro 
            180                 185                 190         


Gly Leu Pro Gly Leu Pro Gly Ser Trp Gly Ala Gly Gly Pro Ala Gly 
        195                 200                 205             


Pro Thr Gly Tyr Pro Gly Glu Pro Gly Leu Val Gly Pro Pro Gly Gln 
    210                 215                 220                 


Pro Gly Arg Pro Gly Leu Lys Gly Asn Pro Gly Val Gly Val Lys Gly 
225                 230                 235                 240 


Gln Met Gly Asp Pro Gly Glu Val Gly Gln Gln Gly Ser Pro Gly Pro 
                245                 250                 255     


Thr Leu Leu Val Glu Pro Pro Asp Phe Cys Leu Tyr Lys Gly Glu Lys 
            260                 265                 270         


Gly Ile Lys Gly Ile Pro Gly Met Val Gly Leu Pro Gly Pro Pro Gly 
        275                 280                 285             


Arg Lys Gly Glu Ser Gly Ile Gly 
    290                 295     


<210>  3302
<211>  73
<212>  PRT
<213>  Homo Sapiens

<400>  3302

Phe Ala Ser Arg Asn Asp Tyr Ser Tyr Trp Leu Ser Thr Pro Glu Pro 
1               5                   10                  15      


Met Pro Met Ser Met Gln Pro Leu Lys Gly Gln Ser Ile Gln Pro Phe 
            20                  25                  30          


Ile Ser Arg Cys Ala Val Cys Glu Ala Pro Ala Val Val Ile Ala Val 
        35                  40                  45              


His Ser Gln Thr Ile Gln Ile Pro His Cys Pro Gln Gly Trp Asp Ser 
    50                  55                  60                  


Leu Trp Ile Gly Tyr Ser Phe Met Met 
65                  70              


<210>  3303
<211>  695
<212>  PRT
<213>  Homo Sapiens

<400>  3303

Met Gly Pro Pro Gly Pro Pro Gly Phe Pro Gly Glu Arg Gly Gln Lys 
1               5                   10                  15      


Gly Asp Glu Gly Pro Pro Gly Ile Ser Ile Pro Gly Pro Pro Gly Leu 
            20                  25                  30          


Asp Gly Gln Pro Gly Ala Pro Gly Leu Pro Gly Pro Pro Gly Pro Ala 
        35                  40                  45              


Gly Pro His Ile Pro Pro Ser Asp Glu Ile Cys Glu Pro Gly Pro Pro 
    50                  55                  60                  


Gly Pro Pro Gly Ser Pro Gly Asp Lys Gly Leu Gln Gly Glu Gln Gly 
65                  70                  75                  80  


Val Lys Gly Asp Lys Gly Asp Thr Cys Phe Asn Cys Ile Gly Thr Gly 
                85                  90                  95      


Ile Ser Gly Pro Pro Gly Gln Pro Gly Leu Pro Gly Leu Pro Gly Pro 
            100                 105                 110         


Pro Gly Ser Leu Gly Phe Pro Gly Gln Lys Gly Glu Lys Gly Gln Ala 
        115                 120                 125             


Gly Ala Thr Gly Pro Lys Gly Leu Pro Gly Ile Pro Gly Ala Pro Gly 
    130                 135                 140                 


Ala Pro Gly Phe Pro Gly Ser Lys Gly Glu Pro Gly Asp Ile Leu Thr 
145                 150                 155                 160 


Phe Pro Gly Met Lys Gly Asp Lys Gly Glu Leu Gly Ser Pro Gly Ala 
                165                 170                 175     


Pro Gly Leu Pro Gly Leu Pro Gly Thr Pro Gly Gln Asp Gly Leu Pro 
            180                 185                 190         


Gly Leu Pro Gly Pro Lys Gly Glu Pro Gly Gly Ile Thr Phe Lys Gly 
        195                 200                 205             


Glu Arg Gly Pro Pro Gly Asn Pro Gly Leu Pro Gly Leu Pro Gly Asn 
    210                 215                 220                 


Ile Gly Pro Met Gly Pro Pro Gly Phe Gly Pro Pro Gly Pro Val Gly 
225                 230                 235                 240 


Glu Lys Gly Ile Gln Gly Val Ala Gly Asn Pro Gly Gln Pro Gly Ile 
                245                 250                 255     


Pro Gly Pro Lys Gly Asp Pro Gly Gln Thr Ile Thr Gln Pro Gly Lys 
            260                 265                 270         


Pro Gly Leu Pro Gly Asn Pro Gly Arg Asp Gly Asp Val Gly Leu Pro 
        275                 280                 285             


Gly Asp Pro Gly Leu Pro Gly Gln Pro Gly Leu Pro Gly Ile Pro Gly 
    290                 295                 300                 


Ser Lys Gly Glu Pro Gly Ile Pro Gly Ile Gly Leu Pro Gly Pro Pro 
305                 310                 315                 320 


Gly Pro Lys Gly Phe Pro Gly Ile Pro Gly Pro Pro Gly Ala Pro Gly 
                325                 330                 335     


Thr Pro Gly Arg Ile Gly Leu Glu Gly Pro Pro Gly Pro Pro Gly Phe 
            340                 345                 350         


Pro Gly Pro Lys Gly Glu Pro Gly Phe Ala Leu Pro Gly Pro Pro Gly 
        355                 360                 365             


Pro Pro Gly Leu Pro Gly Phe Lys Gly Ala Leu Gly Pro Lys Gly Asp 
    370                 375                 380                 


Arg Gly Phe Pro Gly Pro Pro Gly Pro Pro Gly Arg Thr Gly Leu Asp 
385                 390                 395                 400 


Gly Leu Pro Gly Pro Lys Gly Asp Val Gly Pro Asn Gly Gln Pro Gly 
                405                 410                 415     


Pro Met Gly Pro Pro Gly Leu Pro Gly Ile Gly Val Gln Gly Pro Pro 
            420                 425                 430         


Gly Pro Pro Gly Ile Pro Gly Pro Ile Gly Gln Pro Gly Leu His Gly 
        435                 440                 445             


Ile Pro Gly Glu Lys Gly Asp Pro Gly Pro Pro Gly Leu Asp Val Pro 
    450                 455                 460                 


Gly Pro Pro Gly Glu Arg Gly Ser Pro Gly Ile Pro Gly Ala Pro Gly 
465                 470                 475                 480 


Pro Ile Gly Pro Pro Gly Ser Pro Gly Leu Pro Gly Lys Ala Gly Ala 
                485                 490                 495     


Ser Gly Phe Pro Gly Thr Lys Gly Glu Met Gly Met Met Gly Pro Pro 
            500                 505                 510         


Gly Pro Pro Gly Pro Leu Gly Ile Pro Gly Arg Ser Gly Val Pro Gly 
        515                 520                 525             


Leu Lys Gly Asp Asp Gly Leu Gln Gly Gln Pro Gly Leu Pro Gly Pro 
    530                 535                 540                 


Thr Gly Glu Lys Gly Ser Lys Gly Glu Pro Gly Leu Pro Gly Pro Pro 
545                 550                 555                 560 


Gly Pro Met Asp Pro Asn Leu Leu Gly Ser Lys Gly Glu Lys Gly Glu 
                565                 570                 575     


Pro Gly Leu Pro Gly Ile Pro Gly Val Ser Gly Pro Lys Gly Tyr Gln 
            580                 585                 590         


Gly Leu Pro Gly Asp Pro Gly Gln Pro Gly Leu Ser Gly Gln Pro Gly 
        595                 600                 605             


Leu Pro Gly Pro Pro Gly Pro Lys Gly Asn Pro Gly Leu Pro Gly Gln 
    610                 615                 620                 


Pro Gly Leu Ile Gly Pro Pro Gly Leu Lys Gly Thr Ile Gly Asp Met 
625                 630                 635                 640 


Gly Phe Pro Gly Pro Gln Gly Val Glu Gly Pro Pro Gly Pro Ser Gly 
                645                 650                 655     


Val Pro Gly Gln Pro Gly Ser Pro Gly Leu Pro Gly Gln Lys Gly Asp 
            660                 665                 670         


Lys Gly Asp Pro Gly Ile Ser Ser Ile Gly Leu Pro Gly Leu Pro Gly 
        675                 680                 685             


Pro Lys Val Ile Phe Gly Ile 
    690                 695 


<210>  3304
<211>  1691
<212>  PRT
<213>  Homo Sapiens

<400>  3304

Met Lys Leu Arg Gly Val Ser Leu Ala Ala Gly Leu Phe Leu Leu Ala 
1               5                   10                  15      


Leu Ser Leu Trp Gly Gln Pro Ala Glu Ala Ala Ala Cys Tyr Gly Cys 
            20                  25                  30          


Ser Pro Gly Ser Lys Cys Asp Cys Ser Gly Ile Lys Gly Glu Lys Gly 
        35                  40                  45              


Glu Arg Gly Phe Pro Gly Leu Glu Gly His Pro Gly Leu Pro Gly Phe 
    50                  55                  60                  


Pro Gly Pro Glu Gly Pro Pro Gly Pro Arg Gly Gln Lys Gly Asp Asp 
65                  70                  75                  80  


Gly Ile Pro Gly Pro Pro Gly Pro Lys Gly Ile Arg Gly Pro Pro Gly 
                85                  90                  95      


Leu Pro Gly Phe Pro Gly Thr Pro Gly Leu Pro Gly Met Pro Gly His 
            100                 105                 110         


Asp Gly Ala Pro Gly Pro Gln Gly Ile Pro Gly Cys Asn Gly Thr Lys 
        115                 120                 125             


Gly Glu Arg Gly Phe Pro Gly Ser Pro Gly Phe Pro Gly Leu Gln Gly 
    130                 135                 140                 


Pro Pro Gly Pro Pro Gly Ile Pro Gly Met Lys Gly Glu Pro Gly Ser 
145                 150                 155                 160 


Ile Ile Met Ser Ser Leu Pro Gly Pro Lys Gly Asn Pro Gly Tyr Pro 
                165                 170                 175     


Gly Pro Pro Gly Ile Gln Gly Leu Pro Gly Pro Thr Gly Ile Pro Gly 
            180                 185                 190         


Pro Ile Gly Pro Pro Gly Pro Pro Gly Leu Met Gly Pro Pro Gly Pro 
        195                 200                 205             


Pro Gly Leu Pro Gly Pro Lys Gly Asn Met Gly Leu Asn Phe Gln Gly 
    210                 215                 220                 


Pro Lys Gly Glu Lys Gly Glu Gln Gly Leu Gln Gly Pro Pro Gly Pro 
225                 230                 235                 240 


Pro Gly Gln Ile Ser Glu Gln Lys Arg Pro Ile Asp Val Glu Phe Gln 
                245                 250                 255     


Lys Gly Asp Gln Gly Leu Pro Gly Asp Arg Gly Pro Pro Gly Pro Pro 
            260                 265                 270         


Gly Ile Arg Gly Pro Pro Gly Pro Pro Gly Gly Glu Lys Gly Glu Lys 
        275                 280                 285             


Gly Glu Gln Gly Glu Pro Gly Lys Arg Gly Lys Pro Gly Lys Asp Gly 
    290                 295                 300                 


Glu Asn Gly Gln Pro Gly Ile Pro Gly Leu Pro Gly Asp Pro Gly Tyr 
305                 310                 315                 320 


Pro Gly Glu Pro Gly Arg Asp Gly Glu Lys Gly Gln Lys Gly Asp Thr 
                325                 330                 335     


Gly Pro Pro Gly Pro Pro Gly Leu Val Ile Pro Arg Pro Gly Thr Gly 
            340                 345                 350         


Ile Thr Ile Gly Glu Lys Gly Asn Ile Gly Leu Pro Gly Leu Pro Gly 
        355                 360                 365             


Glu Lys Gly Glu Arg Gly Phe Pro Gly Ile Gln Gly Pro Pro Gly Leu 
    370                 375                 380                 


Pro Gly Pro Pro Gly Ala Ala Val Met Gly Pro Pro Gly Pro Pro Gly 
385                 390                 395                 400 


Phe Pro Gly Glu Arg Gly Gln Lys Gly Asp Glu Gly Pro Pro Gly Ile 
                405                 410                 415     


Ser Ile Pro Gly Pro Pro Gly Leu Asp Gly Gln Pro Gly Ala Pro Gly 
            420                 425                 430         


Leu Pro Gly Pro Pro Gly Pro Ala Gly Pro His Ile Pro Pro Ser Asp 
        435                 440                 445             


Glu Ile Cys Glu Pro Gly Pro Pro Gly Pro Pro Gly Ser Pro Gly Asp 
    450                 455                 460                 


Lys Gly Leu Gln Gly Glu Gln Gly Val Lys Gly Asp Lys Gly Asp Thr 
465                 470                 475                 480 


Cys Phe Asn Cys Ile Gly Thr Gly Ile Ser Gly Pro Pro Gly Gln Pro 
                485                 490                 495     


Gly Leu Pro Gly Leu Pro Gly Pro Pro Gly Ser Leu Gly Phe Pro Gly 
            500                 505                 510         


Gln Lys Gly Glu Lys Gly Gln Ala Gly Ala Thr Gly Pro Lys Gly Leu 
        515                 520                 525             


Pro Gly Ile Pro Gly Ala Pro Gly Ala Pro Gly Phe Pro Gly Ser Lys 
    530                 535                 540                 


Gly Glu Pro Gly Asp Ile Leu Thr Phe Pro Gly Met Lys Gly Asp Lys 
545                 550                 555                 560 


Gly Glu Leu Gly Ser Pro Gly Ala Pro Gly Leu Pro Gly Leu Pro Gly 
                565                 570                 575     


Thr Pro Gly Gln Asp Gly Leu Pro Gly Leu Pro Gly Pro Lys Gly Glu 
            580                 585                 590         


Pro Gly Gly Ile Thr Phe Lys Gly Glu Arg Gly Pro Pro Gly Asn Pro 
        595                 600                 605             


Gly Leu Pro Gly Leu Pro Gly Asn Ile Gly Pro Met Gly Pro Pro Gly 
    610                 615                 620                 


Phe Gly Pro Pro Gly Pro Val Gly Glu Lys Gly Ile Gln Gly Val Ala 
625                 630                 635                 640 


Gly Asn Pro Gly Gln Pro Gly Ile Pro Gly Pro Lys Gly Asp Pro Gly 
                645                 650                 655     


Gln Thr Ile Thr Gln Pro Gly Lys Pro Gly Leu Pro Gly Asn Pro Gly 
            660                 665                 670         


Arg Asp Gly Asp Val Gly Leu Pro Gly Asp Pro Gly Leu Pro Gly Gln 
        675                 680                 685             


Pro Gly Leu Pro Gly Ile Pro Gly Ser Lys Gly Glu Pro Gly Ile Pro 
    690                 695                 700                 


Gly Ile Gly Leu Pro Gly Pro Pro Gly Pro Lys Gly Phe Pro Gly Ile 
705                 710                 715                 720 


Pro Gly Pro Pro Gly Ala Pro Gly Thr Pro Gly Arg Ile Gly Leu Glu 
                725                 730                 735     


Gly Pro Pro Gly Pro Pro Gly Phe Pro Gly Pro Lys Gly Glu Pro Gly 
            740                 745                 750         


Phe Ala Leu Pro Gly Pro Pro Gly Pro Pro Gly Leu Pro Gly Phe Lys 
        755                 760                 765             


Gly Ala Leu Gly Pro Lys Gly Asp Arg Gly Phe Pro Gly Pro Pro Gly 
    770                 775                 780                 


Pro Pro Gly Arg Thr Gly Leu Asp Gly Leu Pro Gly Pro Lys Gly Asp 
785                 790                 795                 800 


Val Gly Pro Asn Gly Gln Pro Gly Pro Met Gly Pro Pro Gly Leu Pro 
                805                 810                 815     


Gly Ile Gly Val Gln Gly Pro Pro Gly Pro Pro Gly Ile Pro Gly Pro 
            820                 825                 830         


Ile Gly Gln Pro Gly Leu His Gly Ile Pro Gly Glu Lys Gly Asp Pro 
        835                 840                 845             


Gly Pro Pro Gly Leu Asp Val Pro Gly Pro Pro Gly Glu Arg Gly Ser 
    850                 855                 860                 


Pro Gly Ile Pro Gly Ala Pro Gly Pro Ile Gly Pro Pro Gly Ser Pro 
865                 870                 875                 880 


Gly Leu Pro Gly Lys Ala Gly Ala Ser Gly Phe Pro Gly Thr Lys Gly 
                885                 890                 895     


Glu Met Gly Met Met Gly Pro Pro Gly Pro Pro Gly Pro Leu Gly Ile 
            900                 905                 910         


Pro Gly Arg Ser Gly Val Pro Gly Leu Lys Gly Asp Asp Gly Leu Gln 
        915                 920                 925             


Gly Gln Pro Gly Leu Pro Gly Pro Thr Gly Glu Lys Gly Ser Lys Gly 
    930                 935                 940                 


Glu Pro Gly Leu Pro Gly Pro Pro Gly Pro Met Asp Pro Asn Leu Leu 
945                 950                 955                 960 


Gly Ser Lys Gly Glu Lys Gly Glu Pro Gly Leu Pro Gly Ile Pro Gly 
                965                 970                 975     


Val Ser Gly Pro Lys Gly Tyr Gln Gly Leu Pro Gly Asp Pro Gly Gln 
            980                 985                 990         


Pro Gly Leu Ser Gly Gln Pro Gly  Leu Pro Gly Pro Pro  Gly Pro Lys 
        995                 1000                 1005             


Gly Asn  Pro Gly Leu Pro Gly  Gln Pro Gly Leu Ile  Gly Pro Pro 
    1010                 1015                 1020             


Gly Leu  Lys Gly Thr Ile Gly  Asp Met Gly Phe Pro  Gly Pro Gln 
    1025                 1030                 1035             


Gly Val  Glu Gly Pro Pro Gly  Pro Ser Gly Val Pro  Gly Gln Pro 
    1040                 1045                 1050             


Gly Ser  Pro Gly Leu Pro Gly  Gln Lys Gly Asp Lys  Gly Asp Pro 
    1055                 1060                 1065             


Gly Ile  Ser Ser Ile Gly Leu  Pro Gly Leu Pro Gly  Pro Lys Gly 
    1070                 1075                 1080             


Glu Pro  Gly Leu Pro Gly Tyr  Pro Gly Asn Pro Gly  Ile Lys Gly 
    1085                 1090                 1095             


Ser Val  Gly Asp Pro Gly Leu  Pro Gly Leu Pro Gly  Thr Pro Gly 
    1100                 1105                 1110             


Ala Lys  Gly Gln Pro Gly Leu  Pro Gly Phe Pro Gly  Thr Pro Gly 
    1115                 1120                 1125             


Pro Pro  Gly Pro Lys Gly Ile  Ser Gly Pro Pro Gly  Asn Pro Gly 
    1130                 1135                 1140             


Leu Pro  Gly Glu Pro Gly Pro  Val Gly Gly Gly Gly  His Pro Gly 
    1145                 1150                 1155             


Gln Pro  Gly Pro Pro Gly Glu  Lys Gly Lys Pro Gly  Gln Asp Gly 
    1160                 1165                 1170             


Ile Pro  Gly Pro Ala Gly Gln  Lys Gly Glu Pro Gly  Gln Pro Gly 
    1175                 1180                 1185             


Phe Gly  Asn Pro Gly Pro Pro  Gly Leu Pro Gly Leu  Ser Gly Gln 
    1190                 1195                 1200             


Lys Gly  Asp Gly Gly Leu Pro  Gly Ile Pro Gly Asn  Pro Gly Leu 
    1205                 1210                 1215             


Pro Gly  Pro Lys Gly Glu Pro  Gly Phe His Gly Phe  Pro Gly Val 
    1220                 1225                 1230             


Gln Gly  Pro Pro Gly Pro Pro  Gly Ser Pro Gly Pro  Ala Leu Glu 
    1235                 1240                 1245             


Gly Pro  Lys Gly Asn Pro Gly  Pro Gln Gly Pro Pro  Gly Arg Pro 
    1250                 1255                 1260             


Gly Pro  Thr Gly Phe Gln Gly  Leu Pro Gly Pro Glu  Gly Pro Pro 
    1265                 1270                 1275             


Gly Leu  Pro Gly Asn Gly Gly  Ile Lys Gly Glu Lys  Gly Asn Pro 
    1280                 1285                 1290             


Gly Gln  Pro Gly Leu Pro Gly  Leu Pro Gly Leu Lys  Gly Asp Gln 
    1295                 1300                 1305             


Gly Pro  Pro Gly Leu Gln Gly  Asn Pro Gly Arg Pro  Gly Leu Asn 
    1310                 1315                 1320             


Gly Met  Lys Gly Asp Pro Gly  Leu Pro Gly Val Pro  Gly Phe Pro 
    1325                 1330                 1335             


Gly Met  Lys Gly Pro Ser Gly  Val Pro Gly Ser Ala  Gly Pro Glu 
    1340                 1345                 1350             


Gly Glu  Pro Gly Leu Ile Gly  Pro Pro Gly Pro Pro  Gly Leu Pro 
    1355                 1360                 1365             


Gly Pro  Ser Gly Gln Ser Ile  Ile Ile Lys Gly Asp  Ala Gly Pro 
    1370                 1375                 1380             


Pro Gly  Ile Pro Gly Gln Pro  Gly Leu Lys Gly Leu  Pro Gly Pro 
    1385                 1390                 1395             


Gln Gly  Pro Gln Gly Leu Pro  Gly Pro Thr Gly Pro  Pro Gly Asp 
    1400                 1405                 1410             


Pro Gly  Arg Asn Gly Leu Pro  Gly Phe Asp Gly Ala  Gly Gly Arg 
    1415                 1420                 1425             


Lys Gly  Asp Pro Gly Leu Pro  Gly Gln Pro Gly Thr  Arg Gly Leu 
    1430                 1435                 1440             


Asp Gly  Pro Pro Gly Pro Asp  Gly Leu Gln Gly Pro  Pro Gly Pro 
    1445                 1450                 1455             


Pro Gly  Thr Ser Ser Val Ala  His Gly Phe Leu Ile  Thr Arg His 
    1460                 1465                 1470             


Ser Gln  Thr Thr Asp Ala Pro  Gln Cys Pro Gln Gly  Thr Leu Gln 
    1475                 1480                 1485             


Val Tyr  Glu Gly Phe Ser Leu  Leu Tyr Val Gln Gly  Asn Lys Arg 
    1490                 1495                 1500             


Ala His  Gly Gln Asp Leu Gly  Thr Ala Gly Ser Cys  Leu Arg Arg 
    1505                 1510                 1515             


Phe Ser  Thr Met Pro Phe Met  Phe Cys Asn Ile Asn  Asn Val Cys 
    1520                 1525                 1530             


Asn Phe  Ala Ser Arg Asn Asp  Tyr Ser Tyr Trp Leu  Ser Thr Pro 
    1535                 1540                 1545             


Glu Pro  Met Pro Met Ser Met  Gln Pro Leu Lys Gly  Gln Ser Ile 
    1550                 1555                 1560             


Gln Pro  Phe Ile Ser Arg Cys  Ala Val Cys Glu Ala  Pro Ala Val 
    1565                 1570                 1575             


Val Ile  Ala Val His Ser Gln  Thr Ile Gln Ile Pro  His Cys Pro 
    1580                 1585                 1590             


Gln Gly  Trp Asp Ser Leu Trp  Ile Gly Tyr Ser Phe  Met Met His 
    1595                 1600                 1605             


Thr Ser  Ala Gly Ala Glu Gly  Ser Gly Gln Ala Leu  Ala Ser Pro 
    1610                 1615                 1620             


Gly Ser  Cys Leu Glu Glu Phe  Arg Ser Ala Pro Phe  Ile Glu Cys 
    1625                 1630                 1635             


His Gly  Arg Gly Thr Cys Asn  Tyr Tyr Ala Asn Ser  Tyr Ser Phe 
    1640                 1645                 1650             


Trp Leu  Ala Thr Val Asp Val  Ser Asp Met Phe Ser  Lys Pro Gln 
    1655                 1660                 1665             


Ser Glu  Thr Leu Lys Ala Gly  Asp Leu Arg Thr Arg  Ile Ser Arg 
    1670                 1675                 1680             


Cys Gln  Val Cys Met Lys Arg  Thr 
    1685                 1690     


<210>  3305
<211>  1685
<212>  PRT
<213>  Homo Sapiens

<400>  3305

Met Lys Leu Arg Gly Val Ser Leu Ala Ala Gly Leu Phe Leu Leu Ala 
1               5                   10                  15      


Leu Ser Leu Trp Gly Gln Pro Ala Glu Ala Ala Ala Cys Tyr Gly Cys 
            20                  25                  30          


Ser Pro Gly Ser Lys Cys Asp Cys Ser Gly Ile Lys Gly Glu Lys Gly 
        35                  40                  45              


Glu Arg Gly Phe Pro Gly Leu Glu Gly His Pro Gly Leu Pro Gly Phe 
    50                  55                  60                  


Pro Gly Pro Glu Gly Pro Pro Gly Pro Arg Gly Gln Lys Gly Asp Asp 
65                  70                  75                  80  


Gly Ile Pro Gly Pro Pro Gly Pro Lys Gly Ile Arg Gly Pro Pro Gly 
                85                  90                  95      


Leu Pro Gly Phe Pro Gly Thr Pro Gly Leu Pro Gly Met Pro Gly His 
            100                 105                 110         


Asp Gly Ala Pro Gly Pro Gln Gly Ile Pro Gly Cys Asn Gly Thr Lys 
        115                 120                 125             


Gly Glu Arg Gly Phe Pro Gly Ser Pro Gly Phe Pro Gly Leu Gln Gly 
    130                 135                 140                 


Pro Pro Gly Pro Pro Gly Ile Pro Gly Met Lys Gly Glu Pro Gly Ser 
145                 150                 155                 160 


Ile Ile Met Ser Ser Leu Pro Gly Pro Lys Gly Asn Pro Gly Tyr Pro 
                165                 170                 175     


Gly Pro Pro Gly Ile Gln Gly Leu Pro Gly Pro Thr Gly Ile Pro Gly 
            180                 185                 190         


Pro Ile Gly Pro Pro Gly Pro Pro Gly Leu Met Gly Pro Pro Gly Pro 
        195                 200                 205             


Pro Gly Leu Pro Gly Pro Lys Gly Asn Met Gly Leu Asn Phe Gln Gly 
    210                 215                 220                 


Pro Lys Gly Glu Lys Gly Glu Gln Gly Leu Gln Gly Pro Pro Gly Pro 
225                 230                 235                 240 


Pro Gly Gln Ile Ser Glu Gln Lys Arg Pro Ile Asp Val Glu Phe Gln 
                245                 250                 255     


Lys Gly Asp Gln Gly Leu Pro Gly Asp Arg Gly Pro Pro Gly Pro Pro 
            260                 265                 270         


Gly Ile Arg Gly Pro Pro Gly Pro Pro Gly Gly Glu Lys Gly Glu Lys 
        275                 280                 285             


Gly Glu Gln Gly Glu Pro Gly Lys Arg Gly Lys Pro Gly Lys Asp Gly 
    290                 295                 300                 


Glu Asn Gly Gln Pro Gly Ile Pro Gly Leu Pro Gly Asp Pro Gly Tyr 
305                 310                 315                 320 


Pro Gly Glu Pro Gly Arg Asp Gly Glu Lys Gly Gln Lys Gly Asp Thr 
                325                 330                 335     


Gly Pro Pro Gly Pro Pro Gly Leu Val Ile Pro Arg Pro Gly Thr Gly 
            340                 345                 350         


Ile Thr Ile Gly Glu Lys Gly Asn Ile Gly Leu Pro Gly Leu Pro Gly 
        355                 360                 365             


Glu Lys Gly Glu Arg Gly Phe Pro Gly Ile Gln Gly Pro Pro Gly Leu 
    370                 375                 380                 


Pro Gly Pro Pro Gly Ala Ala Val Met Gly Pro Pro Gly Pro Pro Gly 
385                 390                 395                 400 


Phe Pro Gly Glu Arg Gly Gln Lys Gly Asp Glu Gly Pro Pro Gly Ile 
                405                 410                 415     


Ser Ile Pro Gly Pro Pro Gly Leu Asp Gly Gln Pro Gly Ala Pro Gly 
            420                 425                 430         


Leu Pro Gly Pro Pro Gly Pro Ala Gly Pro His Ile Pro Pro Ser Asp 
        435                 440                 445             


Glu Ile Cys Glu Pro Gly Pro Pro Gly Pro Pro Gly Ser Pro Gly Asp 
    450                 455                 460                 


Lys Gly Leu Gln Gly Glu Gln Gly Val Lys Gly Asp Lys Gly Asp Thr 
465                 470                 475                 480 


Cys Phe Asn Cys Ile Gly Thr Gly Ile Ser Gly Pro Pro Gly Gln Pro 
                485                 490                 495     


Gly Leu Pro Gly Leu Pro Gly Pro Pro Gly Ser Leu Gly Phe Pro Gly 
            500                 505                 510         


Gln Lys Gly Glu Lys Gly Gln Ala Gly Ala Thr Gly Pro Lys Gly Leu 
        515                 520                 525             


Pro Gly Ile Pro Gly Ala Pro Gly Ala Pro Gly Phe Pro Gly Ser Lys 
    530                 535                 540                 


Gly Glu Pro Gly Asp Ile Leu Thr Phe Pro Gly Met Lys Gly Asp Lys 
545                 550                 555                 560 


Gly Glu Leu Gly Ser Pro Gly Ala Pro Gly Leu Pro Gly Leu Pro Gly 
                565                 570                 575     


Thr Pro Gly Gln Asp Gly Leu Pro Gly Leu Pro Gly Pro Lys Gly Glu 
            580                 585                 590         


Pro Gly Gly Ile Thr Phe Lys Gly Glu Arg Gly Pro Pro Gly Asn Pro 
        595                 600                 605             


Gly Leu Pro Gly Leu Pro Gly Asn Ile Gly Pro Met Gly Pro Pro Gly 
    610                 615                 620                 


Phe Gly Pro Pro Gly Pro Val Gly Glu Lys Gly Ile Gln Gly Val Ala 
625                 630                 635                 640 


Gly Asn Pro Gly Gln Pro Gly Ile Pro Gly Pro Lys Gly Asp Pro Gly 
                645                 650                 655     


Gln Thr Ile Thr Gln Pro Gly Lys Pro Gly Leu Pro Gly Asn Pro Gly 
            660                 665                 670         


Arg Asp Gly Asp Val Gly Leu Pro Gly Asp Pro Gly Leu Pro Gly Gln 
        675                 680                 685             


Pro Gly Leu Pro Gly Ile Pro Gly Ser Lys Gly Glu Pro Gly Ile Pro 
    690                 695                 700                 


Gly Ile Gly Leu Pro Gly Pro Pro Gly Pro Lys Gly Phe Pro Gly Ile 
705                 710                 715                 720 


Pro Gly Pro Pro Gly Ala Pro Gly Thr Pro Gly Arg Ile Gly Leu Glu 
                725                 730                 735     


Gly Pro Pro Gly Pro Pro Gly Phe Pro Gly Pro Lys Gly Glu Pro Gly 
            740                 745                 750         


Phe Ala Leu Pro Gly Pro Pro Gly Pro Pro Gly Leu Pro Gly Phe Lys 
        755                 760                 765             


Gly Ala Leu Gly Pro Lys Gly Asp Arg Gly Phe Pro Gly Pro Pro Gly 
    770                 775                 780                 


Pro Pro Gly Arg Thr Gly Leu Asp Gly Leu Pro Gly Pro Lys Gly Asp 
785                 790                 795                 800 


Val Gly Pro Asn Gly Gln Pro Gly Pro Met Gly Pro Pro Gly Leu Pro 
                805                 810                 815     


Gly Ile Gly Val Gln Gly Pro Pro Gly Pro Pro Gly Ile Pro Gly Pro 
            820                 825                 830         


Ile Gly Gln Pro Gly Leu His Gly Ile Pro Gly Glu Lys Gly Asp Pro 
        835                 840                 845             


Gly Pro Pro Gly Leu Asp Val Pro Gly Pro Pro Gly Glu Arg Gly Ser 
    850                 855                 860                 


Pro Gly Ile Pro Gly Ala Pro Gly Pro Ile Gly Pro Pro Gly Ser Pro 
865                 870                 875                 880 


Gly Leu Pro Gly Lys Ala Gly Ala Ser Gly Phe Pro Gly Thr Lys Gly 
                885                 890                 895     


Glu Met Gly Met Met Gly Pro Pro Gly Pro Pro Gly Pro Leu Gly Ile 
            900                 905                 910         


Pro Gly Arg Ser Gly Val Pro Gly Leu Lys Gly Asp Asp Gly Leu Gln 
        915                 920                 925             


Gly Gln Pro Gly Leu Pro Gly Pro Thr Gly Glu Lys Gly Ser Lys Gly 
    930                 935                 940                 


Glu Pro Gly Leu Pro Gly Pro Pro Gly Pro Met Asp Pro Asn Leu Leu 
945                 950                 955                 960 


Gly Ser Lys Gly Glu Lys Gly Glu Pro Gly Leu Pro Gly Ile Pro Gly 
                965                 970                 975     


Val Ser Gly Pro Lys Gly Tyr Gln Gly Leu Pro Gly Asp Pro Gly Gln 
            980                 985                 990         


Pro Gly Leu Ser Gly Gln Pro Gly  Leu Pro Gly Pro Pro  Gly Pro Lys 
        995                 1000                 1005             


Gly Asn  Pro Gly Leu Pro Gly  Gln Pro Gly Leu Ile  Gly Pro Pro 
    1010                 1015                 1020             


Gly Leu  Lys Gly Thr Ile Gly  Asp Met Gly Phe Pro  Gly Pro Gln 
    1025                 1030                 1035             


Gly Val  Glu Gly Pro Pro Gly  Pro Ser Gly Val Pro  Gly Gln Pro 
    1040                 1045                 1050             


Gly Ser  Pro Gly Leu Pro Gly  Gln Lys Gly Asp Lys  Gly Asp Pro 
    1055                 1060                 1065             


Gly Ile  Ser Ser Ile Gly Leu  Pro Gly Leu Pro Gly  Pro Lys Gly 
    1070                 1075                 1080             


Glu Pro  Gly Leu Pro Gly Tyr  Pro Gly Asn Pro Gly  Ile Lys Gly 
    1085                 1090                 1095             


Ser Val  Gly Asp Pro Gly Leu  Pro Gly Leu Pro Gly  Thr Pro Gly 
    1100                 1105                 1110             


Ala Lys  Gly Gln Pro Gly Leu  Pro Gly Phe Pro Gly  Thr Pro Gly 
    1115                 1120                 1125             


Pro Pro  Gly Pro Lys Gly Ile  Ser Gly Pro Pro Gly  Asn Pro Gly 
    1130                 1135                 1140             


Leu Pro  Gly Glu Pro Gly Pro  Val Gly Gly Gly Gly  His Pro Gly 
    1145                 1150                 1155             


Gln Pro  Gly Pro Pro Gly Glu  Lys Gly Lys Pro Gly  Gln Asp Gly 
    1160                 1165                 1170             


Ile Pro  Gly Pro Ala Gly Gln  Lys Gly Glu Pro Gly  Gln Pro Gly 
    1175                 1180                 1185             


Phe Gly  Asn Pro Gly Pro Pro  Gly Leu Pro Gly Leu  Ser Gly Gln 
    1190                 1195                 1200             


Lys Gly  Asp Gly Gly Leu Pro  Gly Ile Pro Gly Asn  Pro Gly Leu 
    1205                 1210                 1215             


Pro Gly  Pro Lys Gly Glu Pro  Gly Phe His Gly Phe  Pro Gly Val 
    1220                 1225                 1230             


Gln Gly  Pro Pro Gly Pro Pro  Gly Ser Pro Gly Pro  Ala Leu Glu 
    1235                 1240                 1245             


Gly Pro  Lys Gly Asn Pro Gly  Pro Gln Gly Pro Pro  Gly Arg Pro 
    1250                 1255                 1260             


Gly Leu  Pro Gly Pro Glu Gly  Pro Pro Gly Leu Pro  Gly Asn Gly 
    1265                 1270                 1275             


Gly Ile  Lys Gly Glu Lys Gly  Asn Pro Gly Gln Pro  Gly Leu Pro 
    1280                 1285                 1290             


Gly Leu  Pro Gly Leu Lys Gly  Asp Gln Gly Pro Pro  Gly Leu Gln 
    1295                 1300                 1305             


Gly Asn  Pro Gly Arg Pro Gly  Leu Asn Gly Met Lys  Gly Asp Pro 
    1310                 1315                 1320             


Gly Leu  Pro Gly Val Pro Gly  Phe Pro Gly Met Lys  Gly Pro Ser 
    1325                 1330                 1335             


Gly Val  Pro Gly Ser Ala Gly  Pro Glu Gly Glu Pro  Gly Leu Ile 
    1340                 1345                 1350             


Gly Pro  Pro Gly Pro Pro Gly  Leu Pro Gly Pro Ser  Gly Gln Ser 
    1355                 1360                 1365             


Ile Ile  Ile Lys Gly Asp Ala  Gly Pro Pro Gly Ile  Pro Gly Gln 
    1370                 1375                 1380             


Pro Gly  Leu Lys Gly Leu Pro  Gly Pro Gln Gly Pro  Gln Gly Leu 
    1385                 1390                 1395             


Pro Gly  Pro Thr Gly Pro Pro  Gly Asp Pro Gly Arg  Asn Gly Leu 
    1400                 1405                 1410             


Pro Gly  Phe Asp Gly Ala Gly  Gly Arg Lys Gly Asp  Pro Gly Leu 
    1415                 1420                 1425             


Pro Gly  Gln Pro Gly Thr Arg  Gly Leu Asp Gly Pro  Pro Gly Pro 
    1430                 1435                 1440             


Asp Gly  Leu Gln Gly Pro Pro  Gly Pro Pro Gly Thr  Ser Ser Val 
    1445                 1450                 1455             


Ala His  Gly Phe Leu Ile Thr  Arg His Ser Gln Thr  Thr Asp Ala 
    1460                 1465                 1470             


Pro Gln  Cys Pro Gln Gly Thr  Leu Gln Val Tyr Glu  Gly Phe Ser 
    1475                 1480                 1485             


Leu Leu  Tyr Val Gln Gly Asn  Lys Arg Ala His Gly  Gln Asp Leu 
    1490                 1495                 1500             


Gly Thr  Ala Gly Ser Cys Leu  Arg Arg Phe Ser Thr  Met Pro Phe 
    1505                 1510                 1515             


Met Phe  Cys Asn Ile Asn Asn  Val Cys Asn Phe Ala  Ser Arg Asn 
    1520                 1525                 1530             


Asp Tyr  Ser Tyr Trp Leu Ser  Thr Pro Glu Pro Met  Pro Met Ser 
    1535                 1540                 1545             


Met Gln  Pro Leu Lys Gly Gln  Ser Ile Gln Pro Phe  Ile Ser Arg 
    1550                 1555                 1560             


Cys Ala  Val Cys Glu Ala Pro  Ala Val Val Ile Ala  Val His Ser 
    1565                 1570                 1575             


Gln Thr  Ile Gln Ile Pro His  Cys Pro Gln Gly Trp  Asp Ser Leu 
    1580                 1585                 1590             


Trp Ile  Gly Tyr Ser Phe Met  Met His Thr Ser Ala  Gly Ala Glu 
    1595                 1600                 1605             


Gly Ser  Gly Gln Ala Leu Ala  Ser Pro Gly Ser Cys  Leu Glu Glu 
    1610                 1615                 1620             


Phe Arg  Ser Ala Pro Phe Ile  Glu Cys His Gly Arg  Gly Thr Cys 
    1625                 1630                 1635             


Asn Tyr  Tyr Ala Asn Ser Tyr  Ser Phe Trp Leu Ala  Thr Val Asp 
    1640                 1645                 1650             


Val Ser  Asp Met Phe Ser Lys  Pro Gln Ser Glu Thr  Leu Lys Ala 
    1655                 1660                 1665             


Gly Asp  Leu Arg Thr Arg Ile  Ser Arg Cys Gln Val  Cys Met Lys 
    1670                 1675                 1680             


Arg Thr  
    1685 


<210>  3306
<211>  40
<212>  PRT
<213>  Homo Sapiens

<400>  3306

Met Lys Leu Arg Gly Val Ser Leu Ala Ala Gly Leu Phe Leu Leu Ala 
1               5                   10                  15      


Leu Ser Leu Trp Gly Gln Pro Ala Glu Ala Ala Glu Glu Thr Leu Phe 
            20                  25                  30          


Ala Thr Pro Val Thr Gln Ala Phe 
        35                  40  


<210>  3307
<211>  174
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3307

Xaa Asp Asp Gly Leu Gln Gly Gln Pro Gly Leu Pro Gly Pro Thr Gly 
1               5                   10                  15      


Glu Lys Gly Ser Lys Gly Glu Pro Gly Leu Pro Gly Pro Pro Gly Pro 
            20                  25                  30          


Met Asp Pro Asn Leu Leu Gly Ser Lys Gly Glu Lys Gly Glu Pro Gly 
        35                  40                  45              


Leu Pro Gly Ile Pro Gly Val Ser Gly Pro Lys Gly Tyr Gln Gly Leu 
    50                  55                  60                  


Pro Gly Asp Pro Gly Gln Pro Gly Leu Ser Gly Gln Pro Gly Leu Pro 
65                  70                  75                  80  


Gly Pro Pro Gly Pro Lys Gly Asn Pro Gly Leu Pro Gly Gln Pro Gly 
                85                  90                  95      


Leu Ile Gly Pro Pro Gly Leu Lys Gly Thr Ile Gly Asp Met Gly Phe 
            100                 105                 110         


Pro Gly Pro Gln Gly Val Glu Gly Pro Pro Gly Pro Ser Gly Val Pro 
        115                 120                 125             


Gly Gln Pro Gly Ser Pro Gly Leu Pro Gly Gln Lys Gly Asp Lys Gly 
    130                 135                 140                 


Asp Pro Gly Ile Ser Ser Ile Gly Leu Pro Gly Leu Pro Gly Pro Lys 
145                 150                 155                 160 


Met Ile Arg Arg Tyr Val Leu Gly Phe Val Ala Ser Pro Lys 
                165                 170                 


<210>  3308
<211>  115
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3308

Xaa Gly Leu Pro Gly Pro Thr Gly Pro Pro Gly Asp Pro Gly Arg Asn 
1               5                   10                  15      


Gly Leu Pro Gly Phe Asp Gly Ala Gly Gly Arg Lys Gly Asp Pro Gly 
            20                  25                  30          


Leu Pro Gly Gln Pro Gly Thr Arg Gly Leu Asp Gly Pro Pro Gly Pro 
        35                  40                  45              


Asp Gly Leu Gln Gly Pro Pro Gly Pro Pro Gly Thr Ser Ser Val Ala 
    50                  55                  60                  


His Gly Phe Leu Ile Thr Arg His Ser Gln Thr Thr Asp Ala Pro Gln 
65                  70                  75                  80  


Cys Pro Gln Gly Thr Leu Gln Val Tyr Glu Gly Phe Ser Leu Leu Tyr 
                85                  90                  95      


Val Gln Gly Asn Lys Arg Ala His Gly Gln Asp Leu Val Asn Leu Ser 
            100                 105                 110         


Gln Lys Arg 
        115 


<210>  3309
<211>  1690
<212>  PRT
<213>  Homo Sapiens

<400>  3309

Met His Pro Gly Leu Trp Leu Leu Leu Val Thr Leu Cys Leu Thr Glu 
1               5                   10                  15      


Glu Leu Ala Ala Ala Gly Glu Lys Ser Tyr Gly Lys Pro Cys Gly Gly 
            20                  25                  30          


Gln Asp Cys Ser Gly Ser Cys Gln Cys Phe Pro Glu Lys Gly Ala Arg 
        35                  40                  45              


Gly Arg Pro Gly Pro Ile Gly Ile Gln Gly Pro Thr Gly Pro Gln Gly 
    50                  55                  60                  


Phe Thr Gly Ser Thr Gly Leu Ser Gly Leu Lys Gly Glu Arg Gly Phe 
65                  70                  75                  80  


Pro Gly Leu Leu Gly Pro Tyr Gly Pro Lys Gly Asp Lys Gly Pro Met 
                85                  90                  95      


Gly Val Pro Gly Phe Leu Gly Ile Asn Gly Ile Pro Gly His Pro Gly 
            100                 105                 110         


Gln Pro Gly Pro Arg Gly Pro Pro Gly Leu Asp Gly Cys Asn Gly Thr 
        115                 120                 125             


Gln Gly Ala Val Gly Phe Pro Gly Pro Asp Gly Tyr Pro Gly Leu Leu 
    130                 135                 140                 


Gly Pro Pro Gly Leu Pro Gly Gln Lys Gly Ser Lys Gly Asp Pro Val 
145                 150                 155                 160 


Leu Ala Pro Gly Ser Phe Lys Gly Met Lys Gly Asp Pro Gly Leu Pro 
                165                 170                 175     


Gly Leu Asp Gly Ile Thr Gly Pro Gln Gly Ala Pro Gly Phe Pro Gly 
            180                 185                 190         


Ala Val Gly Pro Ala Gly Pro Pro Gly Leu Gln Gly Pro Pro Gly Pro 
        195                 200                 205             


Pro Gly Pro Leu Gly Pro Asp Gly Asn Met Gly Leu Gly Phe Gln Gly 
    210                 215                 220                 


Glu Lys Gly Val Lys Gly Asp Val Gly Leu Pro Gly Pro Ala Gly Pro 
225                 230                 235                 240 


Pro Pro Ser Thr Gly Glu Leu Glu Phe Met Gly Phe Pro Lys Gly Lys 
                245                 250                 255     


Lys Gly Ser Lys Gly Glu Pro Gly Pro Lys Gly Phe Pro Gly Ile Ser 
            260                 265                 270         


Gly Pro Pro Gly Phe Pro Gly Leu Gly Thr Thr Gly Glu Lys Gly Glu 
        275                 280                 285             


Lys Gly Glu Lys Gly Ile Pro Gly Leu Pro Gly Pro Arg Gly Pro Met 
    290                 295                 300                 


Gly Ser Glu Gly Val Gln Gly Pro Pro Gly Gln Gln Gly Lys Lys Gly 
305                 310                 315                 320 


Thr Leu Gly Phe Pro Gly Leu Asn Gly Phe Gln Gly Ile Glu Gly Gln 
                325                 330                 335     


Lys Gly Asp Ile Gly Leu Pro Gly Pro Asp Val Phe Ile Asp Ile Asp 
            340                 345                 350         


Gly Ala Val Ile Ser Gly Asn Pro Gly Asp Pro Gly Val Pro Gly Leu 
        355                 360                 365             


Pro Gly Leu Lys Gly Asp Glu Gly Ile Gln Gly Leu Arg Gly Pro Ser 
    370                 375                 380                 


Gly Val Pro Gly Leu Pro Ala Leu Ser Gly Val Pro Gly Ala Leu Gly 
385                 390                 395                 400 


Pro Gln Gly Phe Pro Gly Leu Lys Gly Asp Gln Gly Asn Pro Gly Arg 
                405                 410                 415     


Thr Thr Ile Gly Ala Ala Gly Leu Pro Gly Arg Asp Gly Leu Pro Gly 
            420                 425                 430         


Pro Pro Gly Pro Pro Gly Pro Pro Ser Pro Glu Phe Glu Thr Glu Thr 
        435                 440                 445             


Leu His Asn Lys Glu Ser Gly Phe Pro Gly Leu Arg Gly Glu Gln Gly 
    450                 455                 460                 


Pro Lys Gly Asn Leu Gly Leu Lys Gly Ile Lys Gly Asp Ser Gly Phe 
465                 470                 475                 480 


Cys Ala Cys Asp Gly Gly Val Pro Asn Thr Gly Pro Pro Gly Glu Pro 
                485                 490                 495     


Gly Pro Pro Gly Pro Trp Gly Leu Ile Gly Leu Pro Gly Leu Lys Gly 
            500                 505                 510         


Ala Arg Gly Asp Arg Gly Ser Gly Gly Ala Gln Gly Pro Ala Gly Ala 
        515                 520                 525             


Pro Gly Leu Val Gly Pro Leu Gly Pro Ser Gly Pro Lys Gly Lys Lys 
    530                 535                 540                 


Gly Glu Pro Ile Leu Ser Thr Ile Gln Gly Met Pro Gly Asp Arg Gly 
545                 550                 555                 560 


Asp Ser Gly Ser Gln Gly Phe Arg Gly Val Ile Gly Glu Pro Gly Lys 
                565                 570                 575     


Asp Gly Val Pro Gly Leu Pro Gly Leu Pro Gly Leu Pro Gly Asp Gly 
            580                 585                 590         


Gly Gln Gly Phe Pro Gly Glu Lys Gly Leu Pro Gly Leu Pro Gly Glu 
        595                 600                 605             


Lys Gly His Pro Gly Pro Pro Gly Leu Pro Gly Asn Gly Leu Pro Gly 
    610                 615                 620                 


Leu Pro Gly Pro Arg Gly Leu Pro Gly Asp Lys Gly Lys Asp Gly Leu 
625                 630                 635                 640 


Pro Gly Gln Gln Gly Leu Pro Gly Ser Lys Gly Ile Thr Leu Pro Cys 
                645                 650                 655     


Ile Ile Pro Gly Ser Tyr Gly Pro Ser Gly Phe Pro Gly Thr Pro Gly 
            660                 665                 670         


Phe Pro Gly Pro Lys Gly Ser Arg Gly Leu Pro Gly Thr Pro Gly Gln 
        675                 680                 685             


Pro Gly Ser Ser Gly Ser Lys Gly Glu Pro Gly Ser Pro Gly Leu Val 
    690                 695                 700                 


His Leu Pro Glu Leu Pro Gly Phe Pro Gly Pro Arg Gly Glu Lys Gly 
705                 710                 715                 720 


Leu Pro Gly Phe Pro Gly Leu Pro Gly Lys Asp Gly Leu Pro Gly Met 
                725                 730                 735     


Ile Gly Ser Pro Gly Leu Pro Gly Ser Lys Gly Ala Thr Gly Asp Ile 
            740                 745                 750         


Phe Gly Ala Glu Asn Gly Ala Pro Gly Glu Gln Gly Leu Gln Gly Leu 
        755                 760                 765             


Thr Gly His Lys Gly Phe Leu Gly Asp Ser Gly Leu Pro Gly Leu Lys 
    770                 775                 780                 


Gly Val His Gly Lys Pro Gly Leu Leu Gly Pro Lys Gly Glu Arg Gly 
785                 790                 795                 800 


Ser Pro Gly Thr Pro Gly Gln Val Gly Gln Pro Gly Thr Pro Gly Ser 
                805                 810                 815     


Ser Gly Pro Tyr Gly Ile Lys Gly Lys Ser Gly Leu Pro Gly Ala Pro 
            820                 825                 830         


Gly Phe Pro Gly Ile Ser Gly His Pro Gly Lys Lys Gly Thr Arg Gly 
        835                 840                 845             


Lys Lys Gly Pro Pro Gly Ser Ile Val Lys Lys Gly Leu Pro Gly Leu 
    850                 855                 860                 


Lys Gly Leu Pro Gly Asn Pro Gly Leu Val Gly Leu Lys Gly Ser Pro 
865                 870                 875                 880 


Gly Ser Pro Gly Val Ala Gly Leu Pro Ala Leu Ser Gly Pro Lys Gly 
                885                 890                 895     


Glu Lys Gly Ser Val Gly Phe Val Gly Phe Pro Gly Ile Pro Gly Leu 
            900                 905                 910         


Pro Gly Ile Pro Gly Thr Arg Gly Leu Lys Gly Ile Pro Gly Ser Thr 
        915                 920                 925             


Gly Lys Met Gly Pro Ser Gly Arg Ala Gly Thr Pro Gly Glu Lys Gly 
    930                 935                 940                 


Asp Arg Gly Asn Pro Gly Pro Val Gly Ile Pro Ser Pro Arg Arg Pro 
945                 950                 955                 960 


Met Ser Asn Leu Trp Leu Lys Gly Asp Lys Gly Ser Gln Gly Ser Ala 
                965                 970                 975     


Gly Ser Asn Gly Phe Pro Gly Pro Arg Gly Asp Lys Gly Glu Ala Gly 
            980                 985                 990         


Arg Pro Gly Pro Pro Gly Leu Pro  Gly Ala Pro Gly Leu  Pro Gly Ile 
        995                 1000                 1005             


Ile Lys  Gly Val Ser Gly Lys  Pro Gly Pro Pro Gly  Phe Met Gly 
    1010                 1015                 1020             


Ile Arg  Gly Leu Pro Gly Leu  Lys Gly Ser Ser Gly  Ile Thr Gly 
    1025                 1030                 1035             


Phe Pro  Gly Met Pro Gly Glu  Ser Gly Ser Gln Gly  Ile Arg Gly 
    1040                 1045                 1050             


Ser Pro  Gly Leu Pro Gly Ala  Ser Gly Leu Pro Gly  Leu Lys Gly 
    1055                 1060                 1065             


Asp Asn  Gly Gln Thr Val Glu  Ile Ser Gly Ser Pro  Gly Pro Lys 
    1070                 1075                 1080             


Gly Gln  Pro Gly Glu Ser Gly  Phe Lys Gly Thr Lys  Gly Arg Asp 
    1085                 1090                 1095             


Gly Leu  Ile Gly Asn Ile Gly  Phe Pro Gly Asn Lys  Gly Glu Asp 
    1100                 1105                 1110             


Gly Lys  Val Gly Val Ser Gly  Asp Val Gly Leu Pro  Gly Ala Pro 
    1115                 1120                 1125             


Gly Phe  Pro Gly Val Ala Gly  Met Arg Gly Glu Pro  Gly Leu Pro 
    1130                 1135                 1140             


Gly Ser  Ser Gly His Gln Gly  Ala Ile Gly Pro Leu  Gly Ser Pro 
    1145                 1150                 1155             


Gly Leu  Ile Gly Pro Lys Gly  Phe Pro Gly Phe Pro  Gly Leu His 
    1160                 1165                 1170             


Gly Leu  Asn Gly Leu Pro Gly  Thr Lys Gly Thr His  Gly Thr Pro 
    1175                 1180                 1185             


Gly Pro  Ser Ile Thr Gly Val  Pro Gly Pro Ala Gly  Leu Pro Gly 
    1190                 1195                 1200             


Pro Lys  Gly Glu Lys Gly Tyr  Pro Gly Ile Gly Ile  Gly Ala Pro 
    1205                 1210                 1215             


Gly Lys  Pro Gly Leu Arg Gly  Gln Lys Gly Asp Arg  Gly Phe Pro 
    1220                 1225                 1230             


Gly Leu  Gln Gly Pro Ala Gly  Leu Pro Gly Ala Pro  Gly Ile Ser 
    1235                 1240                 1245             


Leu Pro  Ser Leu Ile Ala Gly  Gln Pro Gly Asp Pro  Gly Arg Pro 
    1250                 1255                 1260             


Gly Leu  Asp Gly Glu Arg Gly  Arg Pro Gly Pro Ala  Gly Pro Pro 
    1265                 1270                 1275             


Gly Pro  Pro Gly Pro Ser Ser  Asn Gln Gly Asp Thr  Gly Asp Pro 
    1280                 1285                 1290             


Gly Phe  Pro Gly Ile Pro Gly  Pro Lys Gly Pro Lys  Gly Asp Gln 
    1295                 1300                 1305             


Gly Ile  Pro Gly Phe Ser Gly  Leu Pro Gly Glu Leu  Gly Leu Lys 
    1310                 1315                 1320             


Gly Met  Arg Gly Glu Pro Gly  Phe Met Gly Thr Pro  Gly Lys Val 
    1325                 1330                 1335             


Gly Pro  Pro Gly Asp Pro Gly  Phe Pro Gly Met Lys  Gly Lys Ala 
    1340                 1345                 1350             


Gly Pro  Arg Gly Ser Ser Gly  Leu Gln Gly Asp Pro  Gly Gln Thr 
    1355                 1360                 1365             


Pro Thr  Ala Glu Ala Val Gln  Val Pro Pro Gly Pro  Leu Gly Leu 
    1370                 1375                 1380             


Pro Gly  Ile Asp Gly Ile Pro  Gly Leu Thr Gly Asp  Pro Gly Ala 
    1385                 1390                 1395             


Gln Gly  Pro Val Gly Leu Gln  Gly Ser Lys Gly Leu  Pro Gly Ile 
    1400                 1405                 1410             


Pro Gly  Lys Asp Gly Pro Ser  Gly Leu Pro Gly Pro  Pro Gly Ala 
    1415                 1420                 1425             


Leu Gly  Asp Pro Gly Leu Pro  Gly Leu Gln Gly Pro  Pro Gly Phe 
    1430                 1435                 1440             


Glu Gly  Ala Pro Gly Gln Gln  Gly Pro Phe Gly Met  Pro Gly Met 
    1445                 1450                 1455             


Pro Gly  Gln Ser Met Arg Val  Gly Tyr Thr Leu Val  Lys His Ser 
    1460                 1465                 1470             


Gln Ser  Glu Gln Val Pro Pro  Cys Pro Ile Gly Met  Ser Gln Leu 
    1475                 1480                 1485             


Trp Val  Gly Tyr Ser Leu Leu  Phe Val Glu Gly Gln  Glu Lys Ala 
    1490                 1495                 1500             


His Asn  Gln Asp Leu Gly Phe  Ala Gly Ser Cys Leu  Pro Arg Phe 
    1505                 1510                 1515             


Ser Thr  Met Pro Phe Ile Tyr  Cys Asn Ile Asn Glu  Val Cys His 
    1520                 1525                 1530             


Tyr Ala  Arg Arg Asn Asp Lys  Ser Tyr Trp Leu Ser  Thr Thr Ala 
    1535                 1540                 1545             


Pro Ile  Pro Met Met Pro Val  Ser Gln Thr Gln Ile  Pro Gln Tyr 
    1550                 1555                 1560             


Ile Ser  Arg Cys Ser Val Cys  Glu Ala Pro Ser Gln  Ala Ile Ala 
    1565                 1570                 1575             


Val His  Ser Gln Asp Ile Thr  Ile Pro Gln Cys Pro  Leu Gly Trp 
    1580                 1585                 1590             


Arg Ser  Leu Trp Ile Gly Tyr  Ser Phe Leu Met His  Thr Ala Ala 
    1595                 1600                 1605             


Gly Ala  Glu Gly Gly Gly Gln  Ser Leu Val Ser Pro  Gly Ser Cys 
    1610                 1615                 1620             


Leu Glu  Asp Phe Arg Ala Thr  Pro Phe Ile Glu Cys  Ser Gly Ala 
    1625                 1630                 1635             


Arg Gly  Thr Cys His Tyr Phe  Ala Asn Lys Tyr Ser  Phe Trp Leu 
    1640                 1645                 1650             


Thr Thr  Val Glu Glu Arg Gln  Gln Phe Gly Glu Leu  Pro Val Ser 
    1655                 1660                 1665             


Glu Thr  Leu Lys Ala Gly Gln  Leu His Thr Arg Val  Ser Arg Cys 
    1670                 1675                 1680             


Gln Val  Cys Met Lys Ser Leu  
    1685                 1690 


<210>  3310
<211>  1707
<212>  PRT
<213>  Homo Sapiens

<400>  3310

Met His Pro Gly Leu Trp Leu Leu Leu Val Thr Leu Cys Leu Thr Glu 
1               5                   10                  15      


Glu Leu Ala Ala Ala Gly Glu Lys Ser Tyr Gly Lys Pro Cys Gly Gly 
            20                  25                  30          


Gln Asp Cys Ser Gly Ser Cys Gln Cys Phe Pro Glu Lys Gly Ala Arg 
        35                  40                  45              


Gly Arg Pro Gly Pro Ile Gly Ile Gln Gly Pro Thr Gly Pro Gln Gly 
    50                  55                  60                  


Phe Thr Gly Ser Thr Gly Leu Ser Gly Leu Lys Gly Glu Arg Gly Phe 
65                  70                  75                  80  


Pro Gly Leu Leu Gly Pro Tyr Gly Pro Lys Gly Asp Lys Gly Pro Met 
                85                  90                  95      


Gly Val Pro Gly Phe Leu Gly Ile Asn Gly Ile Pro Gly His Pro Gly 
            100                 105                 110         


Gln Pro Gly Pro Arg Gly Pro Pro Gly Leu Asp Gly Cys Asn Gly Thr 
        115                 120                 125             


Gln Gly Ala Val Gly Phe Pro Gly Pro Asp Gly Tyr Pro Gly Leu Leu 
    130                 135                 140                 


Gly Pro Pro Gly Leu Pro Gly Gln Lys Gly Ser Lys Gly Asp Pro Val 
145                 150                 155                 160 


Leu Ala Pro Gly Ser Phe Lys Gly Met Lys Gly Asp Pro Gly Leu Pro 
                165                 170                 175     


Gly Leu Asp Gly Ile Thr Gly Pro Gln Gly Ala Pro Gly Phe Pro Gly 
            180                 185                 190         


Ala Val Gly Pro Ala Gly Pro Pro Gly Leu Gln Gly Pro Pro Gly Pro 
        195                 200                 205             


Pro Gly Pro Leu Gly Pro Asp Gly Asn Met Gly Leu Gly Phe Gln Gly 
    210                 215                 220                 


Glu Lys Gly Val Lys Gly Asp Val Gly Leu Pro Gly Pro Ala Gly Pro 
225                 230                 235                 240 


Pro Pro Ser Thr Gly Glu Leu Glu Phe Met Gly Phe Pro Lys Gly Lys 
                245                 250                 255     


Lys Gly Ser Lys Gly Glu Pro Gly Pro Lys Gly Phe Pro Gly Ile Ser 
            260                 265                 270         


Gly Pro Pro Gly Phe Pro Gly Leu Gly Thr Thr Gly Glu Lys Gly Glu 
        275                 280                 285             


Lys Gly Glu Lys Gly Ile Pro Gly Leu Pro Gly Pro Arg Gly Pro Met 
    290                 295                 300                 


Gly Ser Glu Gly Val Gln Gly Pro Pro Gly Gln Gln Gly Lys Lys Gly 
305                 310                 315                 320 


Thr Leu Gly Phe Pro Gly Leu Asn Gly Phe Gln Gly Ile Glu Gly Gln 
                325                 330                 335     


Lys Gly Asp Ile Gly Leu Pro Gly Pro Asp Val Phe Ile Asp Ile Asp 
            340                 345                 350         


Gly Ala Val Ile Ser Gly Asn Pro Gly Asp Pro Gly Val Pro Gly Leu 
        355                 360                 365             


Pro Gly Leu Lys Gly Asp Glu Gly Ile Gln Gly Leu Arg Gly Pro Ser 
    370                 375                 380                 


Gly Val Pro Gly Leu Pro Ala Leu Ser Gly Val Pro Gly Ala Leu Gly 
385                 390                 395                 400 


Pro Gln Gly Phe Pro Gly Leu Lys Gly Asp Gln Gly Asn Pro Gly Arg 
                405                 410                 415     


Thr Thr Ile Gly Ala Ala Gly Leu Pro Gly Arg Asp Gly Leu Pro Gly 
            420                 425                 430         


Pro Pro Gly Pro Pro Gly Pro Pro Ser Pro Glu Phe Glu Thr Glu Thr 
        435                 440                 445             


Leu His Asn Lys Glu Ser Gly Phe Pro Gly Leu Arg Gly Glu Gln Gly 
    450                 455                 460                 


Pro Lys Gly Asn Leu Gly Leu Lys Gly Ile Lys Gly Asp Ser Gly Phe 
465                 470                 475                 480 


Cys Ala Cys Asp Gly Gly Val Pro Asn Thr Gly Pro Pro Gly Glu Pro 
                485                 490                 495     


Gly Pro Pro Gly Pro Trp Gly Leu Ile Gly Leu Pro Gly Leu Lys Gly 
            500                 505                 510         


Ala Arg Gly Asp Arg Gly Ser Gly Gly Ala Gln Gly Pro Ala Gly Ala 
        515                 520                 525             


Pro Gly Leu Val Gly Pro Leu Gly Pro Ser Gly Pro Lys Gly Lys Lys 
    530                 535                 540                 


Gly Glu Pro Ile Leu Ser Thr Ile Gln Gly Met Pro Gly Asp Arg Gly 
545                 550                 555                 560 


Asp Ser Gly Ser Gln Gly Phe Arg Gly Val Ile Gly Glu Pro Gly Lys 
                565                 570                 575     


Asp Gly Val Pro Gly Leu Pro Gly Leu Pro Gly Leu Pro Gly Asp Gly 
            580                 585                 590         


Gly Gln Gly Phe Pro Gly Glu Lys Gly Leu Pro Gly Leu Pro Gly Glu 
        595                 600                 605             


Lys Gly His Pro Gly Pro Pro Gly Leu Pro Gly Asn Gly Leu Pro Gly 
    610                 615                 620                 


Leu Pro Gly Pro Arg Gly Leu Pro Gly Asp Lys Gly Lys Asp Gly Leu 
625                 630                 635                 640 


Pro Gly Gln Gln Gly Leu Pro Gly Ser Lys Gly Asp Cys Cys Cys Arg 
                645                 650                 655     


Glu Val Gly Lys Gly Asp Leu Asp Thr Glu Arg Gly Ile Thr Leu Pro 
            660                 665                 670         


Cys Ile Ile Pro Gly Ser Tyr Gly Pro Ser Gly Phe Pro Gly Thr Pro 
        675                 680                 685             


Gly Phe Pro Gly Pro Lys Gly Ser Arg Gly Leu Pro Gly Thr Pro Gly 
    690                 695                 700                 


Gln Pro Gly Ser Ser Gly Ser Lys Gly Glu Pro Gly Ser Pro Gly Leu 
705                 710                 715                 720 


Val His Leu Pro Glu Leu Pro Gly Phe Pro Gly Pro Arg Gly Glu Lys 
                725                 730                 735     


Gly Leu Pro Gly Phe Pro Gly Leu Pro Gly Lys Asp Gly Leu Pro Gly 
            740                 745                 750         


Met Ile Gly Ser Pro Gly Leu Pro Gly Ser Lys Gly Ala Thr Gly Asp 
        755                 760                 765             


Ile Phe Gly Ala Glu Asn Gly Ala Pro Gly Glu Gln Gly Leu Gln Gly 
    770                 775                 780                 


Leu Thr Gly His Lys Gly Phe Leu Gly Asp Ser Gly Leu Pro Gly Leu 
785                 790                 795                 800 


Lys Gly Val His Gly Lys Pro Gly Leu Leu Gly Pro Lys Gly Glu Arg 
                805                 810                 815     


Gly Ser Pro Gly Thr Pro Gly Gln Val Gly Gln Pro Gly Thr Pro Gly 
            820                 825                 830         


Ser Ser Gly Pro Tyr Gly Ile Lys Gly Lys Ser Gly Leu Pro Gly Ala 
        835                 840                 845             


Pro Gly Phe Pro Gly Ile Ser Gly His Pro Gly Lys Lys Gly Thr Arg 
    850                 855                 860                 


Gly Lys Lys Gly Pro Pro Gly Ser Ile Val Lys Lys Gly Leu Pro Gly 
865                 870                 875                 880 


Leu Lys Gly Leu Pro Gly Asn Pro Gly Leu Val Gly Leu Lys Gly Ser 
                885                 890                 895     


Pro Gly Ser Pro Gly Val Ala Gly Leu Pro Ala Leu Ser Gly Pro Lys 
            900                 905                 910         


Gly Glu Lys Gly Ser Val Gly Phe Val Gly Phe Pro Gly Ile Pro Gly 
        915                 920                 925             


Leu Pro Gly Ile Pro Gly Thr Arg Gly Leu Lys Gly Ile Pro Gly Ser 
    930                 935                 940                 


Thr Gly Lys Met Gly Pro Ser Gly Arg Ala Gly Thr Pro Gly Glu Lys 
945                 950                 955                 960 


Gly Asp Arg Gly Asn Pro Gly Pro Val Gly Ile Pro Ser Pro Arg Arg 
                965                 970                 975     


Pro Met Ser Asn Leu Trp Leu Lys Gly Asp Lys Gly Ser Gln Gly Ser 
            980                 985                 990         


Ala Gly Ser Asn Gly Phe Pro Gly  Pro Arg Gly Asp Lys  Gly Glu Ala 
        995                 1000                 1005             


Gly Arg  Pro Gly Pro Pro Gly  Leu Pro Gly Ala Pro  Gly Leu Pro 
    1010                 1015                 1020             


Gly Ile  Ile Lys Gly Val Ser  Gly Lys Pro Gly Pro  Pro Gly Phe 
    1025                 1030                 1035             


Met Gly  Ile Arg Gly Leu Pro  Gly Leu Lys Gly Ser  Ser Gly Ile 
    1040                 1045                 1050             


Thr Gly  Phe Pro Gly Met Pro  Gly Glu Ser Gly Ser  Gln Gly Ile 
    1055                 1060                 1065             


Arg Gly  Ser Pro Gly Leu Pro  Gly Ala Ser Gly Leu  Pro Gly Leu 
    1070                 1075                 1080             


Lys Gly  Asp Asn Gly Gln Thr  Val Glu Ile Ser Gly  Ser Pro Gly 
    1085                 1090                 1095             


Pro Lys  Gly Gln Pro Gly Glu  Ser Gly Phe Lys Gly  Thr Lys Gly 
    1100                 1105                 1110             


Arg Asp  Gly Leu Ile Gly Asn  Ile Gly Phe Pro Gly  Asn Lys Gly 
    1115                 1120                 1125             


Glu Asp  Gly Lys Val Gly Val  Ser Gly Asp Val Gly  Leu Pro Gly 
    1130                 1135                 1140             


Ala Pro  Gly Phe Pro Gly Val  Ala Gly Met Arg Gly  Glu Pro Gly 
    1145                 1150                 1155             


Leu Pro  Gly Ser Ser Gly His  Gln Gly Ala Ile Gly  Pro Leu Gly 
    1160                 1165                 1170             


Ser Pro  Gly Leu Ile Gly Pro  Lys Gly Phe Pro Gly  Phe Pro Gly 
    1175                 1180                 1185             


Leu His  Gly Leu Asn Gly Leu  Pro Gly Thr Lys Gly  Thr His Gly 
    1190                 1195                 1200             


Thr Pro  Gly Pro Ser Ile Thr  Gly Val Pro Gly Pro  Ala Gly Leu 
    1205                 1210                 1215             


Pro Gly  Pro Lys Gly Glu Lys  Gly Tyr Pro Gly Ile  Gly Ile Gly 
    1220                 1225                 1230             


Ala Pro  Gly Lys Pro Gly Leu  Arg Gly Gln Lys Gly  Asp Arg Gly 
    1235                 1240                 1245             


Phe Pro  Gly Leu Gln Gly Pro  Ala Gly Leu Pro Gly  Ala Pro Gly 
    1250                 1255                 1260             


Ile Ser  Leu Pro Ser Leu Ile  Ala Gly Gln Pro Gly  Asp Pro Gly 
    1265                 1270                 1275             


Arg Pro  Gly Leu Asp Gly Glu  Arg Gly Arg Pro Gly  Pro Ala Gly 
    1280                 1285                 1290             


Pro Pro  Gly Pro Pro Gly Pro  Ser Ser Asn Gln Gly  Asp Thr Gly 
    1295                 1300                 1305             


Asp Pro  Gly Phe Pro Gly Ile  Pro Gly Pro Lys Gly  Pro Lys Gly 
    1310                 1315                 1320             


Asp Gln  Gly Ile Pro Gly Phe  Ser Gly Leu Pro Gly  Glu Leu Gly 
    1325                 1330                 1335             


Leu Lys  Gly Met Arg Gly Glu  Pro Gly Phe Met Gly  Thr Pro Gly 
    1340                 1345                 1350             


Lys Val  Gly Pro Pro Gly Asp  Pro Gly Phe Pro Gly  Met Lys Gly 
    1355                 1360                 1365             


Lys Ala  Gly Pro Arg Gly Ser  Ser Gly Leu Gln Gly  Asp Pro Gly 
    1370                 1375                 1380             


Gln Thr  Pro Thr Ala Glu Ala  Val Gln Val Pro Pro  Gly Pro Leu 
    1385                 1390                 1395             


Gly Leu  Pro Gly Ile Asp Gly  Ile Pro Gly Leu Thr  Gly Asp Pro 
    1400                 1405                 1410             


Gly Ala  Gln Gly Pro Val Gly  Leu Gln Gly Ser Lys  Gly Leu Pro 
    1415                 1420                 1425             


Gly Ile  Pro Gly Lys Asp Gly  Pro Ser Gly Leu Pro  Gly Pro Pro 
    1430                 1435                 1440             


Gly Ala  Leu Gly Asp Pro Gly  Leu Pro Gly Leu Gln  Gly Pro Pro 
    1445                 1450                 1455             


Gly Phe  Glu Gly Ala Pro Gly  Gln Gln Gly Pro Phe  Gly Met Pro 
    1460                 1465                 1470             


Gly Met  Pro Gly Gln Ser Met  Arg Val Gly Tyr Thr  Leu Val Lys 
    1475                 1480                 1485             


His Ser  Gln Ser Glu Gln Val  Pro Pro Cys Pro Ile  Gly Met Ser 
    1490                 1495                 1500             


Gln Leu  Trp Val Gly Tyr Ser  Leu Leu Phe Val Glu  Gly Gln Glu 
    1505                 1510                 1515             


Lys Ala  His Asn Gln Asp Leu  Gly Phe Ala Gly Ser  Cys Leu Pro 
    1520                 1525                 1530             


Arg Phe  Ser Thr Met Pro Phe  Ile Tyr Cys Asn Ile  Asn Glu Val 
    1535                 1540                 1545             


Cys His  Tyr Ala Arg Arg Asn  Asp Lys Ser Tyr Trp  Leu Ser Thr 
    1550                 1555                 1560             


Thr Ala  Pro Ile Pro Met Met  Pro Val Ser Gln Thr  Gln Ile Pro 
    1565                 1570                 1575             


Gln Tyr  Ile Ser Arg Cys Ser  Val Cys Glu Ala Pro  Ser Gln Ala 
    1580                 1585                 1590             


Ile Ala  Val His Ser Gln Asp  Ile Thr Ile Pro Gln  Cys Pro Leu 
    1595                 1600                 1605             


Gly Trp  Arg Ser Leu Trp Ile  Gly Tyr Ser Phe Leu  Met His Thr 
    1610                 1615                 1620             


Ala Ala  Gly Ala Glu Gly Gly  Gly Gln Ser Leu Val  Ser Pro Gly 
    1625                 1630                 1635             


Ser Cys  Leu Glu Asp Phe Arg  Ala Thr Pro Phe Ile  Glu Cys Ser 
    1640                 1645                 1650             


Gly Ala  Arg Gly Thr Cys His  Tyr Phe Ala Asn Lys  Tyr Ser Phe 
    1655                 1660                 1665             


Trp Leu  Thr Thr Val Glu Glu  Arg Gln Gln Phe Gly  Glu Leu Pro 
    1670                 1675                 1680             


Val Ser  Glu Thr Leu Lys Ala  Gly Gln Leu His Thr  Arg Val Ser 
    1685                 1690                 1695             


Arg Cys  Gln Val Cys Met Lys  Ser Leu 
    1700                 1705         


<210>  3311
<211>  1633
<212>  PRT
<213>  Homo Sapiens

<400>  3311

Met His Pro Gly Leu Trp Leu Leu Leu Val Thr Leu Cys Leu Thr Glu 
1               5                   10                  15      


Glu Leu Ala Ala Ala Gly Glu Lys Ser Tyr Gly Lys Pro Cys Gly Gly 
            20                  25                  30          


Gln Asp Cys Ser Gly Ser Cys Gln Cys Phe Pro Glu Lys Gly Ala Arg 
        35                  40                  45              


Gly Arg Pro Gly Pro Ile Gly Ile Gln Gly Pro Thr Gly Pro Gln Gly 
    50                  55                  60                  


Phe Thr Gly Ser Thr Gly Leu Ser Gly Leu Lys Gly Glu Arg Gly Phe 
65                  70                  75                  80  


Pro Gly Leu Leu Gly Pro Tyr Gly Pro Lys Gly Asp Lys Gly Pro Met 
                85                  90                  95      


Gly Val Pro Gly Phe Leu Gly Ile Asn Gly Ile Pro Gly His Pro Gly 
            100                 105                 110         


Gln Pro Gly Pro Arg Gly Pro Pro Gly Leu Asp Gly Cys Asn Gly Thr 
        115                 120                 125             


Gln Gly Ala Val Gly Phe Pro Gly Pro Asp Gly Tyr Pro Gly Leu Leu 
    130                 135                 140                 


Gly Pro Pro Gly Leu Pro Gly Gln Lys Gly Ser Lys Gly Asp Pro Val 
145                 150                 155                 160 


Leu Ala Pro Gly Ser Phe Lys Gly Met Lys Gly Asp Pro Gly Leu Pro 
                165                 170                 175     


Gly Leu Asp Gly Ile Thr Gly Pro Gln Gly Ala Pro Gly Phe Pro Gly 
            180                 185                 190         


Ala Val Gly Pro Ala Gly Pro Pro Gly Leu Gln Gly Pro Pro Gly Pro 
        195                 200                 205             


Pro Gly Pro Leu Gly Pro Asp Gly Asn Met Gly Leu Gly Phe Gln Gly 
    210                 215                 220                 


Glu Lys Gly Val Lys Gly Asp Val Gly Leu Pro Gly Pro Ala Gly Pro 
225                 230                 235                 240 


Pro Pro Ser Thr Gly Glu Leu Glu Phe Met Gly Phe Pro Lys Gly Lys 
                245                 250                 255     


Lys Gly Ser Lys Gly Glu Pro Gly Pro Lys Gly Phe Pro Gly Ile Ser 
            260                 265                 270         


Gly Pro Pro Gly Phe Pro Gly Leu Gly Thr Thr Gly Glu Lys Gly Glu 
        275                 280                 285             


Lys Gly Glu Lys Gly Ile Pro Gly Leu Pro Gly Pro Arg Gly Pro Met 
    290                 295                 300                 


Gly Ser Glu Gly Val Gln Gly Pro Pro Gly Gln Gln Gly Lys Lys Gly 
305                 310                 315                 320 


Thr Leu Gly Phe Pro Gly Leu Asn Gly Phe Gln Gly Ile Glu Gly Gln 
                325                 330                 335     


Lys Gly Asp Ile Gly Leu Pro Gly Pro Asp Val Phe Ile Asp Ile Asp 
            340                 345                 350         


Gly Ala Val Ile Ser Gly Asn Pro Gly Asp Pro Gly Val Pro Gly Leu 
        355                 360                 365             


Pro Gly Leu Lys Gly Asp Glu Gly Ile Gln Gly Leu Arg Gly Pro Ser 
    370                 375                 380                 


Gly Val Pro Gly Leu Pro Ala Leu Ser Gly Val Pro Gly Ala Leu Gly 
385                 390                 395                 400 


Pro Gln Gly Phe Pro Gly Leu Lys Gly Asp Gln Gly Asn Pro Gly Arg 
                405                 410                 415     


Thr Thr Ile Gly Ala Ala Gly Leu Pro Gly Arg Asp Gly Leu Pro Gly 
            420                 425                 430         


Pro Pro Gly Pro Pro Gly Pro Pro Ser Pro Glu Phe Glu Thr Glu Thr 
        435                 440                 445             


Leu His Asn Lys Glu Ser Gly Phe Pro Gly Leu Arg Gly Glu Gln Gly 
    450                 455                 460                 


Pro Lys Gly Asn Leu Gly Leu Lys Gly Ile Lys Gly Asp Ser Gly Phe 
465                 470                 475                 480 


Cys Ala Cys Asp Gly Gly Val Pro Asn Thr Gly Pro Pro Gly Glu Pro 
                485                 490                 495     


Gly Pro Pro Gly Pro Trp Gly Leu Ile Gly Leu Pro Gly Leu Lys Gly 
            500                 505                 510         


Ala Arg Gly Asp Arg Gly Ser Gly Gly Ala Gln Gly Pro Ala Gly Ala 
        515                 520                 525             


Pro Gly Leu Val Gly Pro Leu Gly Pro Ser Gly Pro Lys Gly Lys Lys 
    530                 535                 540                 


Gly Glu Pro Ile Leu Ser Thr Ile Gln Gly Met Pro Gly Asp Arg Gly 
545                 550                 555                 560 


Asp Ser Gly Ser Gln Gly Phe Arg Gly Val Ile Gly Glu Pro Gly Lys 
                565                 570                 575     


Asp Gly Val Pro Gly Leu Pro Gly Leu Pro Gly Leu Pro Gly Asp Gly 
            580                 585                 590         


Gly Gln Gly Phe Pro Gly Glu Lys Gly Leu Pro Gly Leu Pro Gly Glu 
        595                 600                 605             


Lys Gly His Pro Gly Pro Pro Gly Leu Pro Gly Asn Gly Leu Pro Gly 
    610                 615                 620                 


Leu Pro Gly Pro Arg Gly Leu Pro Gly Asp Lys Gly Lys Asp Gly Leu 
625                 630                 635                 640 


Pro Gly Gln Gln Gly Leu Pro Gly Ser Lys Gly Ile Thr Leu Pro Cys 
                645                 650                 655     


Ile Ile Pro Gly Ser Tyr Gly Pro Ser Gly Phe Pro Gly Thr Pro Gly 
            660                 665                 670         


Phe Pro Gly Pro Lys Gly Ser Arg Gly Leu Pro Gly Thr Pro Gly Gln 
        675                 680                 685             


Pro Gly Ser Ser Gly Ser Lys Gly Glu Pro Gly Ser Pro Gly Leu Val 
    690                 695                 700                 


His Leu Pro Glu Leu Pro Gly Phe Pro Gly Pro Arg Gly Glu Lys Gly 
705                 710                 715                 720 


Leu Pro Gly Phe Pro Gly Leu Pro Gly Lys Asp Gly Leu Pro Gly Met 
                725                 730                 735     


Ile Gly Ser Pro Gly Leu Pro Gly Ser Lys Gly Ala Thr Gly Asp Ile 
            740                 745                 750         


Phe Gly Ala Glu Asn Gly Ala Pro Gly Glu Gln Gly Leu Gln Gly Leu 
        755                 760                 765             


Thr Gly His Lys Gly Phe Leu Gly Asp Ser Gly Leu Pro Gly Leu Lys 
    770                 775                 780                 


Gly Val His Gly Lys Pro Gly Leu Leu Gly Pro Lys Gly Glu Arg Gly 
785                 790                 795                 800 


Ser Pro Gly Thr Pro Gly Gln Val Gly Gln Pro Gly Thr Pro Gly Ser 
                805                 810                 815     


Ser Gly Pro Tyr Gly Ile Lys Gly Lys Ser Gly Leu Pro Gly Ala Pro 
            820                 825                 830         


Gly Phe Pro Gly Ile Ser Gly His Pro Gly Lys Lys Gly Thr Arg Gly 
        835                 840                 845             


Lys Lys Gly Pro Pro Gly Ser Ile Val Lys Lys Gly Leu Pro Gly Leu 
    850                 855                 860                 


Lys Gly Leu Pro Gly Asn Pro Gly Leu Val Gly Leu Lys Gly Ser Pro 
865                 870                 875                 880 


Gly Ser Pro Gly Val Ala Gly Leu Pro Ala Leu Ser Gly Pro Lys Gly 
                885                 890                 895     


Glu Lys Gly Ser Val Gly Phe Val Gly Phe Pro Gly Ile Pro Gly Leu 
            900                 905                 910         


Pro Gly Ile Pro Gly Thr Arg Gly Leu Lys Gly Ile Pro Gly Ser Thr 
        915                 920                 925             


Gly Lys Met Gly Pro Ser Gly Arg Ala Gly Thr Pro Gly Glu Lys Gly 
    930                 935                 940                 


Asp Arg Gly Asn Pro Gly Pro Val Gly Ile Pro Ser Pro Arg Arg Pro 
945                 950                 955                 960 


Met Ser Asn Leu Trp Leu Lys Gly Asp Lys Gly Ser Gln Gly Ser Ala 
                965                 970                 975     


Gly Ser Asn Gly Phe Pro Gly Pro Arg Gly Asp Lys Gly Glu Ala Gly 
            980                 985                 990         


Arg Pro Gly Pro Pro Gly Leu Pro  Gly Ala Pro Gly Leu  Pro Gly Ile 
        995                 1000                 1005             


Ile Lys  Gly Val Ser Gly Lys  Pro Gly Pro Pro Gly  Phe Met Gly 
    1010                 1015                 1020             


Ile Arg  Gly Leu Pro Gly Leu  Lys Gly Ser Ser Gly  Ile Thr Gly 
    1025                 1030                 1035             


Phe Pro  Gly Met Pro Gly Glu  Ser Gly Ser Gln Gly  Ile Arg Gly 
    1040                 1045                 1050             


Ser Pro  Gly Leu Pro Gly Ala  Ser Gly Leu Pro Gly  Leu Lys Gly 
    1055                 1060                 1065             


Asp Asn  Gly Gln Thr Val Glu  Ile Ser Gly Ser Pro  Gly Pro Lys 
    1070                 1075                 1080             


Gly Gln  Pro Gly Glu Ser Gly  Phe Lys Gly Thr Lys  Gly Arg Asp 
    1085                 1090                 1095             


Gly Leu  Ile Gly Asn Ile Gly  Phe Pro Gly Asn Lys  Gly Glu Asp 
    1100                 1105                 1110             


Gly Lys  Val Gly Val Ser Gly  Asp Val Gly Leu Pro  Gly Ala Pro 
    1115                 1120                 1125             


Gly Phe  Pro Gly Val Ala Gly  Met Arg Gly Glu Pro  Gly Leu Pro 
    1130                 1135                 1140             


Gly Ser  Ser Gly His Gln Gly  Ala Ile Gly Pro Leu  Gly Ser Pro 
    1145                 1150                 1155             


Gly Leu  Ile Gly Pro Lys Gly  Pro Ser Ile Thr Gly  Val Pro Gly 
    1160                 1165                 1170             


Pro Ala  Gly Leu Pro Gly Pro  Lys Gly Glu Lys Gly  Tyr Pro Gly 
    1175                 1180                 1185             


Ile Gly  Ile Gly Ala Pro Gly  Lys Pro Gly Leu Arg  Gly Gln Lys 
    1190                 1195                 1200             


Gly Asp  Arg Gly Phe Pro Gly  Leu Gln Gly Pro Ala  Gly Leu Pro 
    1205                 1210                 1215             


Gly Ala  Pro Gly Ile Ser Leu  Pro Ser Leu Ile Ala  Gly Gln Pro 
    1220                 1225                 1230             


Gly Asp  Pro Gly Arg Pro Gly  Leu Asp Gly Glu Arg  Gly Arg Pro 
    1235                 1240                 1245             


Gly Pro  Ala Gly Pro Pro Gly  Pro Pro Gly Pro Ser  Ser Asn Gln 
    1250                 1255                 1260             


Gly Asp  Thr Gly Asp Pro Gly  Phe Pro Gly Ile Pro  Gly Pro Lys 
    1265                 1270                 1275             


Gly Pro  Lys Gly Asp Gln Gly  Ile Pro Gly Phe Ser  Gly Leu Pro 
    1280                 1285                 1290             


Gly Glu  Leu Gly Leu Lys Gly  Ser Ser Gly Leu Gln  Gly Asp Pro 
    1295                 1300                 1305             


Gly Gln  Thr Pro Thr Ala Glu  Ala Val Gln Val Pro  Pro Gly Pro 
    1310                 1315                 1320             


Leu Gly  Leu Pro Gly Ile Asp  Gly Ile Pro Gly Leu  Thr Gly Asp 
    1325                 1330                 1335             


Pro Gly  Ala Gln Gly Pro Val  Gly Leu Gln Gly Ser  Lys Gly Leu 
    1340                 1345                 1350             


Pro Gly  Ile Pro Gly Lys Asp  Gly Pro Ser Gly Leu  Pro Gly Pro 
    1355                 1360                 1365             


Pro Gly  Ala Leu Gly Asp Pro  Gly Leu Pro Gly Leu  Gln Gly Pro 
    1370                 1375                 1380             


Pro Gly  Phe Glu Gly Ala Pro  Gly Gln Gln Gly Pro  Phe Gly Met 
    1385                 1390                 1395             


Pro Gly  Met Pro Gly Gln Ser  Met Arg Val Gly Tyr  Thr Leu Val 
    1400                 1405                 1410             


Lys His  Ser Gln Ser Glu Gln  Val Pro Pro Cys Pro  Ile Gly Met 
    1415                 1420                 1425             


Ser Gln  Leu Trp Val Gly Tyr  Ser Leu Leu Phe Val  Glu Gly Gln 
    1430                 1435                 1440             


Glu Lys  Ala His Asn Gln Asp  Leu Gly Phe Ala Gly  Ser Cys Leu 
    1445                 1450                 1455             


Pro Arg  Phe Ser Thr Met Pro  Phe Ile Tyr Cys Asn  Ile Asn Glu 
    1460                 1465                 1470             


Val Cys  His Tyr Ala Arg Arg  Asn Asp Lys Ser Tyr  Trp Leu Ser 
    1475                 1480                 1485             


Thr Thr  Ala Pro Ile Pro Met  Met Pro Val Ser Gln  Thr Gln Ile 
    1490                 1495                 1500             


Pro Gln  Tyr Ile Ser Arg Cys  Ser Val Cys Glu Ala  Pro Ser Gln 
    1505                 1510                 1515             


Ala Ile  Ala Val His Ser Gln  Asp Ile Thr Ile Pro  Gln Cys Pro 
    1520                 1525                 1530             


Leu Gly  Trp Arg Ser Leu Trp  Ile Gly Tyr Ser Phe  Leu Met His 
    1535                 1540                 1545             


Thr Ala  Ala Gly Ala Glu Gly  Gly Gly Gln Ser Leu  Val Ser Pro 
    1550                 1555                 1560             


Gly Ser  Cys Leu Glu Asp Phe  Arg Ala Thr Pro Phe  Ile Glu Cys 
    1565                 1570                 1575             


Ser Gly  Ala Arg Gly Thr Cys  His Tyr Phe Ala Asn  Lys Tyr Ser 
    1580                 1585                 1590             


Phe Trp  Leu Thr Thr Val Glu  Glu Arg Gln Gln Phe  Gly Glu Leu 
    1595                 1600                 1605             


Pro Val  Ser Glu Thr Leu Lys  Ala Gly Gln Leu His  Thr Arg Val 
    1610                 1615                 1620             


Ser Arg  Cys Gln Val Cys Met  Lys Ser Leu 
    1625                 1630             


<210>  3312
<211>  1678
<212>  PRT
<213>  Homo Sapiens

<400>  3312

Met His Pro Gly Leu Trp Leu Leu Leu Val Thr Leu Cys Leu Thr Glu 
1               5                   10                  15      


Glu Leu Ala Ala Ala Gly Glu Lys Ser Tyr Gly Lys Pro Cys Gly Gly 
            20                  25                  30          


Gln Asp Cys Ser Gly Ser Cys Gln Cys Phe Pro Glu Lys Gly Ala Arg 
        35                  40                  45              


Gly Arg Pro Gly Pro Ile Gly Ile Gln Gly Pro Thr Gly Pro Gln Gly 
    50                  55                  60                  


Phe Thr Gly Ser Thr Gly Leu Ser Gly Leu Lys Gly Glu Arg Gly Phe 
65                  70                  75                  80  


Pro Gly Leu Leu Gly Pro Tyr Gly Pro Lys Gly Asp Lys Gly Pro Met 
                85                  90                  95      


Gly Val Pro Gly Phe Leu Gly Ile Asn Gly Ile Pro Gly His Pro Gly 
            100                 105                 110         


Gln Pro Gly Pro Arg Gly Pro Pro Gly Leu Asp Gly Cys Asn Gly Thr 
        115                 120                 125             


Gln Gly Ala Val Gly Phe Pro Gly Pro Asp Gly Tyr Pro Gly Leu Leu 
    130                 135                 140                 


Gly Pro Pro Gly Leu Pro Gly Gln Lys Gly Ser Lys Gly Asp Pro Val 
145                 150                 155                 160 


Leu Ala Pro Gly Ser Phe Lys Gly Met Lys Gly Asp Pro Gly Leu Pro 
                165                 170                 175     


Gly Leu Asp Gly Ile Thr Gly Pro Gln Gly Ala Pro Gly Phe Pro Gly 
            180                 185                 190         


Ala Val Gly Pro Ala Gly Pro Pro Gly Leu Gln Gly Pro Pro Gly Pro 
        195                 200                 205             


Pro Gly Pro Leu Gly Pro Asp Gly Asn Met Gly Leu Gly Phe Gln Gly 
    210                 215                 220                 


Glu Lys Gly Val Lys Gly Asp Val Gly Leu Pro Gly Pro Ala Gly Pro 
225                 230                 235                 240 


Pro Pro Ser Thr Gly Glu Leu Glu Phe Met Gly Phe Pro Lys Gly Lys 
                245                 250                 255     


Lys Gly Ser Lys Gly Glu Pro Gly Pro Lys Gly Phe Pro Gly Ile Ser 
            260                 265                 270         


Gly Pro Pro Gly Phe Pro Gly Leu Gly Thr Thr Gly Glu Lys Gly Glu 
        275                 280                 285             


Lys Gly Glu Lys Gly Ile Pro Gly Leu Pro Gly Pro Arg Gly Pro Met 
    290                 295                 300                 


Gly Ser Glu Gly Val Gln Gly Pro Pro Gly Gln Gln Gly Lys Lys Gly 
305                 310                 315                 320 


Thr Leu Gly Phe Pro Gly Leu Asn Gly Phe Gln Gly Ile Glu Gly Gln 
                325                 330                 335     


Lys Gly Asp Ile Gly Leu Pro Gly Pro Asp Val Phe Ile Asp Ile Asp 
            340                 345                 350         


Gly Ala Val Ile Ser Gly Asn Pro Gly Asp Pro Gly Val Pro Gly Leu 
        355                 360                 365             


Pro Gly Leu Lys Gly Asp Glu Gly Ile Gln Gly Leu Arg Gly Pro Ser 
    370                 375                 380                 


Gly Val Pro Gly Leu Pro Ala Leu Ser Gly Val Pro Gly Ala Leu Gly 
385                 390                 395                 400 


Pro Gln Gly Phe Pro Gly Leu Lys Gly Asp Gln Gly Asn Pro Gly Arg 
                405                 410                 415     


Thr Thr Ile Gly Ala Ala Gly Leu Pro Gly Arg Asp Gly Leu Pro Gly 
            420                 425                 430         


Pro Pro Gly Pro Pro Gly Pro Pro Ser Pro Glu Phe Glu Thr Glu Thr 
        435                 440                 445             


Leu His Asn Lys Glu Ser Gly Phe Pro Gly Leu Arg Gly Glu Gln Gly 
    450                 455                 460                 


Pro Lys Gly Asn Leu Gly Leu Lys Gly Ile Lys Gly Asp Ser Gly Phe 
465                 470                 475                 480 


Cys Ala Cys Asp Gly Gly Val Pro Asn Thr Gly Pro Pro Gly Glu Pro 
                485                 490                 495     


Gly Pro Pro Gly Pro Trp Gly Leu Ile Gly Leu Pro Gly Leu Lys Gly 
            500                 505                 510         


Ala Arg Gly Asp Arg Gly Ser Gly Gly Ala Gln Gly Pro Ala Gly Ala 
        515                 520                 525             


Pro Gly Leu Val Gly Pro Leu Gly Pro Ser Gly Pro Lys Gly Lys Lys 
    530                 535                 540                 


Gly Glu Pro Ile Leu Ser Thr Ile Gln Gly Met Pro Gly Asp Arg Gly 
545                 550                 555                 560 


Asp Ser Gly Ser Gln Gly Phe Arg Gly Val Ile Gly Glu Pro Gly Lys 
                565                 570                 575     


Asp Gly Val Pro Gly Leu Pro Gly Leu Pro Gly Leu Pro Gly Asp Gly 
            580                 585                 590         


Gly Gln Gly Phe Pro Gly Glu Lys Gly Leu Pro Gly Leu Pro Gly Glu 
        595                 600                 605             


Lys Gly His Pro Gly Pro Pro Gly Leu Pro Gly Asn Gly Leu Pro Gly 
    610                 615                 620                 


Leu Pro Gly Pro Arg Gly Leu Pro Gly Asp Lys Gly Lys Asp Gly Leu 
625                 630                 635                 640 


Pro Gly Gln Gln Gly Leu Pro Gly Ser Lys Gly Ile Thr Leu Pro Cys 
                645                 650                 655     


Ile Ile Pro Gly Ser Tyr Gly Pro Ser Gly Phe Pro Gly Thr Pro Gly 
            660                 665                 670         


Phe Pro Gly Pro Lys Gly Ser Arg Gly Leu Pro Gly Thr Pro Gly Gln 
        675                 680                 685             


Pro Gly Ser Ser Gly Ser Lys Gly Glu Pro Gly Ser Pro Gly Leu Val 
    690                 695                 700                 


His Leu Pro Glu Leu Pro Gly Phe Pro Gly Pro Arg Gly Glu Lys Gly 
705                 710                 715                 720 


Leu Pro Gly Phe Pro Gly Leu Pro Gly Lys Asp Gly Leu Pro Gly Met 
                725                 730                 735     


Ile Gly Ser Pro Gly Leu Pro Gly Ser Lys Gly Ala Thr Gly Asp Ile 
            740                 745                 750         


Phe Gly Ala Glu Asn Gly Ala Pro Gly Glu Gln Gly Leu Gln Gly Leu 
        755                 760                 765             


Thr Gly His Lys Gly Phe Leu Gly Asp Ser Gly Leu Pro Gly Leu Lys 
    770                 775                 780                 


Gly Val His Gly Lys Pro Gly Leu Leu Gly Pro Lys Gly Glu Arg Gly 
785                 790                 795                 800 


Ser Pro Gly Thr Pro Gly Gln Val Gly Gln Pro Gly Thr Pro Gly Ser 
                805                 810                 815     


Ser Gly Pro Tyr Gly Ile Lys Gly Lys Ser Gly Leu Pro Gly Ala Pro 
            820                 825                 830         


Gly Phe Pro Gly Ile Ser Gly His Pro Gly Lys Lys Gly Thr Arg Gly 
        835                 840                 845             


Lys Lys Gly Pro Pro Gly Ser Ile Val Lys Lys Gly Leu Pro Gly Leu 
    850                 855                 860                 


Lys Gly Leu Pro Gly Asn Pro Gly Leu Val Gly Leu Lys Gly Ser Pro 
865                 870                 875                 880 


Gly Ser Pro Gly Val Ala Gly Leu Pro Ala Leu Ser Gly Pro Lys Gly 
                885                 890                 895     


Glu Lys Gly Ser Val Gly Phe Val Gly Phe Pro Gly Ile Pro Gly Leu 
            900                 905                 910         


Pro Gly Ile Pro Gly Thr Arg Gly Leu Lys Gly Ile Pro Gly Ser Thr 
        915                 920                 925             


Gly Lys Met Gly Pro Ser Gly Arg Ala Gly Thr Pro Gly Glu Lys Gly 
    930                 935                 940                 


Asp Arg Gly Asn Pro Gly Pro Val Gly Ile Pro Ser Pro Arg Arg Pro 
945                 950                 955                 960 


Met Ser Asn Leu Trp Leu Lys Gly Asp Lys Gly Ser Gln Gly Ser Ala 
                965                 970                 975     


Gly Ser Asn Gly Phe Pro Gly Pro Arg Gly Asp Lys Gly Glu Ala Gly 
            980                 985                 990         


Arg Pro Gly Pro Pro Gly Leu Pro  Gly Ala Pro Gly Leu  Pro Gly Ile 
        995                 1000                 1005             


Ile Lys  Gly Val Ser Gly Lys  Pro Gly Pro Pro Gly  Phe Met Gly 
    1010                 1015                 1020             


Ile Arg  Gly Leu Pro Gly Leu  Lys Gly Ser Ser Gly  Ile Thr Gly 
    1025                 1030                 1035             


Phe Pro  Gly Met Pro Gly Glu  Ser Gly Ser Gln Gly  Ile Arg Gly 
    1040                 1045                 1050             


Ser Pro  Gly Leu Pro Gly Ala  Ser Gly Leu Pro Gly  Leu Lys Gly 
    1055                 1060                 1065             


Asp Asn  Gly Gln Thr Val Glu  Ile Ser Gly Ser Pro  Gly Pro Lys 
    1070                 1075                 1080             


Gly Gln  Pro Gly Glu Ser Gly  Phe Lys Gly Thr Lys  Gly Arg Asp 
    1085                 1090                 1095             


Gly Leu  Ile Gly Asn Ile Gly  Phe Pro Gly Asn Lys  Gly Glu Asp 
    1100                 1105                 1110             


Gly Lys  Val Gly Val Ser Gly  Asp Val Gly Leu Pro  Gly Ala Pro 
    1115                 1120                 1125             


Gly Phe  Pro Gly Val Ala Gly  Met Arg Gly Glu Pro  Gly Leu Pro 
    1130                 1135                 1140             


Gly Ser  Ser Gly His Gln Gly  Ala Ile Gly Pro Leu  Gly Ser Pro 
    1145                 1150                 1155             


Gly Leu  Ile Gly Pro Lys Gly  Phe Pro Gly Phe Pro  Gly Leu His 
    1160                 1165                 1170             


Gly Leu  Asn Gly Leu Pro Gly  Thr Lys Gly Thr His  Gly Thr Pro 
    1175                 1180                 1185             


Gly Pro  Ser Ile Thr Gly Val  Pro Gly Pro Ala Gly  Leu Pro Gly 
    1190                 1195                 1200             


Pro Lys  Gly Glu Lys Gly Tyr  Pro Gly Ile Gly Ile  Gly Ala Pro 
    1205                 1210                 1215             


Gly Lys  Pro Gly Leu Arg Gly  Gln Lys Gly Asp Arg  Gly Phe Pro 
    1220                 1225                 1230             


Gly Leu  Gln Gly Pro Ala Gly  Leu Pro Gly Ala Pro  Gly Ile Ser 
    1235                 1240                 1245             


Leu Pro  Ser Leu Ile Ala Gly  Gln Pro Gly Asp Pro  Gly Arg Pro 
    1250                 1255                 1260             


Gly Leu  Asp Gly Glu Arg Gly  Arg Pro Gly Pro Ala  Gly Pro Pro 
    1265                 1270                 1275             


Gly Pro  Pro Gly Pro Ser Ser  Asn Gln Gly Asp Thr  Gly Asp Pro 
    1280                 1285                 1290             


Gly Phe  Pro Gly Ile Pro Gly  Phe Ser Gly Leu Pro  Gly Glu Leu 
    1295                 1300                 1305             


Gly Leu  Lys Gly Met Arg Gly  Glu Pro Gly Phe Met  Gly Thr Pro 
    1310                 1315                 1320             


Gly Lys  Val Gly Pro Pro Gly  Asp Pro Gly Phe Pro  Gly Met Lys 
    1325                 1330                 1335             


Gly Lys  Ala Gly Pro Arg Gly  Ser Ser Gly Leu Gln  Gly Asp Pro 
    1340                 1345                 1350             


Gly Gln  Thr Pro Thr Ala Glu  Ala Val Gln Val Pro  Pro Gly Pro 
    1355                 1360                 1365             


Leu Gly  Leu Pro Gly Ile Asp  Gly Ile Pro Gly Leu  Thr Gly Asp 
    1370                 1375                 1380             


Pro Gly  Ala Gln Gly Pro Val  Gly Leu Gln Gly Ser  Lys Gly Leu 
    1385                 1390                 1395             


Pro Gly  Ile Pro Gly Lys Asp  Gly Pro Ser Gly Leu  Pro Gly Pro 
    1400                 1405                 1410             


Pro Gly  Ala Leu Gly Asp Pro  Gly Leu Pro Gly Leu  Gln Gly Pro 
    1415                 1420                 1425             


Pro Gly  Phe Glu Gly Ala Pro  Gly Gln Gln Gly Pro  Phe Gly Met 
    1430                 1435                 1440             


Pro Gly  Met Pro Gly Gln Ser  Met Arg Val Gly Tyr  Thr Leu Val 
    1445                 1450                 1455             


Lys His  Ser Gln Ser Glu Gln  Val Pro Pro Cys Pro  Ile Gly Met 
    1460                 1465                 1470             


Ser Gln  Leu Trp Val Gly Tyr  Ser Leu Leu Phe Val  Glu Gly Gln 
    1475                 1480                 1485             


Glu Lys  Ala His Asn Gln Asp  Leu Gly Phe Ala Gly  Ser Cys Leu 
    1490                 1495                 1500             


Pro Arg  Phe Ser Thr Met Pro  Phe Ile Tyr Cys Asn  Ile Asn Glu 
    1505                 1510                 1515             


Val Cys  His Tyr Ala Arg Arg  Asn Asp Lys Ser Tyr  Trp Leu Ser 
    1520                 1525                 1530             


Thr Thr  Ala Pro Ile Pro Met  Met Pro Val Ser Gln  Thr Gln Ile 
    1535                 1540                 1545             


Pro Gln  Tyr Ile Ser Arg Cys  Ser Val Cys Glu Ala  Pro Ser Gln 
    1550                 1555                 1560             


Ala Ile  Ala Val His Ser Gln  Asp Ile Thr Ile Pro  Gln Cys Pro 
    1565                 1570                 1575             


Leu Gly  Trp Arg Ser Leu Trp  Ile Gly Tyr Ser Phe  Leu Met His 
    1580                 1585                 1590             


Thr Ala  Ala Gly Ala Glu Gly  Gly Gly Gln Ser Leu  Val Ser Pro 
    1595                 1600                 1605             


Gly Ser  Cys Leu Glu Asp Phe  Arg Ala Thr Pro Phe  Ile Glu Cys 
    1610                 1615                 1620             


Ser Gly  Ala Arg Gly Thr Cys  His Tyr Phe Ala Asn  Lys Tyr Ser 
    1625                 1630                 1635             


Phe Trp  Leu Thr Thr Val Glu  Glu Arg Gln Gln Phe  Gly Glu Leu 
    1640                 1645                 1650             


Pro Val  Ser Glu Thr Leu Lys  Ala Gly Gln Leu His  Thr Arg Val 
    1655                 1660                 1665             


Ser Arg  Cys Gln Val Cys Met  Lys Ser Leu 
    1670                 1675             


<210>  3313
<211>  1666
<212>  PRT
<213>  Homo Sapiens

<400>  3313

Met His Pro Gly Leu Trp Leu Leu Leu Val Thr Leu Cys Leu Thr Glu 
1               5                   10                  15      


Glu Leu Ala Ala Ala Gly Glu Lys Ser Tyr Gly Lys Pro Cys Gly Gly 
            20                  25                  30          


Gln Asp Cys Ser Gly Ser Cys Gln Cys Phe Pro Glu Lys Gly Ala Arg 
        35                  40                  45              


Gly Arg Pro Gly Pro Ile Gly Ile Gln Gly Pro Thr Gly Pro Gln Gly 
    50                  55                  60                  


Phe Thr Gly Ser Thr Gly Leu Ser Gly Leu Lys Gly Glu Arg Gly Phe 
65                  70                  75                  80  


Pro Gly Leu Leu Gly Pro Tyr Gly Pro Lys Gly Asp Lys Gly Pro Met 
                85                  90                  95      


Gly Val Pro Gly Phe Leu Gly Ile Asn Gly Ile Pro Gly His Pro Gly 
            100                 105                 110         


Gln Pro Gly Pro Arg Gly Pro Pro Gly Leu Asp Gly Cys Asn Gly Thr 
        115                 120                 125             


Gln Gly Ala Val Gly Phe Pro Gly Pro Asp Gly Tyr Pro Gly Leu Leu 
    130                 135                 140                 


Gly Pro Pro Gly Leu Pro Gly Gln Lys Gly Ser Lys Gly Asp Pro Val 
145                 150                 155                 160 


Leu Ala Pro Gly Ser Phe Lys Gly Met Lys Gly Asp Pro Gly Leu Pro 
                165                 170                 175     


Gly Leu Asp Gly Ile Thr Gly Pro Gln Gly Ala Pro Gly Phe Pro Gly 
            180                 185                 190         


Ala Val Gly Pro Ala Gly Pro Pro Gly Leu Gln Gly Pro Pro Gly Pro 
        195                 200                 205             


Pro Gly Pro Leu Gly Pro Asp Gly Asn Met Gly Leu Gly Phe Gln Gly 
    210                 215                 220                 


Glu Lys Gly Val Lys Gly Asp Val Gly Leu Pro Gly Pro Ala Gly Pro 
225                 230                 235                 240 


Pro Pro Ser Thr Gly Glu Leu Glu Phe Met Gly Phe Pro Lys Gly Lys 
                245                 250                 255     


Lys Gly Ser Lys Gly Glu Pro Gly Pro Lys Gly Phe Pro Gly Ile Ser 
            260                 265                 270         


Gly Pro Pro Gly Phe Pro Gly Leu Gly Thr Thr Gly Glu Lys Gly Glu 
        275                 280                 285             


Lys Gly Glu Lys Gly Ile Pro Gly Leu Pro Gly Pro Arg Gly Pro Met 
    290                 295                 300                 


Gly Ser Glu Gly Val Gln Gly Pro Pro Gly Gln Gln Gly Lys Lys Gly 
305                 310                 315                 320 


Thr Leu Gly Phe Pro Gly Leu Asn Gly Phe Gln Gly Ile Glu Gly Gln 
                325                 330                 335     


Lys Gly Asp Ile Gly Leu Pro Gly Pro Asp Val Phe Ile Asp Ile Asp 
            340                 345                 350         


Gly Ala Val Ile Ser Gly Asn Pro Gly Asp Pro Gly Val Pro Gly Leu 
        355                 360                 365             


Pro Gly Leu Lys Gly Asp Glu Gly Ile Gln Gly Leu Arg Gly Pro Ser 
    370                 375                 380                 


Gly Val Pro Gly Leu Pro Ala Leu Ser Gly Val Pro Gly Ala Leu Gly 
385                 390                 395                 400 


Pro Gln Gly Phe Pro Gly Leu Lys Gly Asp Gln Gly Asn Pro Gly Arg 
                405                 410                 415     


Thr Thr Ile Gly Ala Ala Gly Leu Pro Gly Arg Asp Gly Leu Pro Gly 
            420                 425                 430         


Pro Pro Gly Pro Pro Gly Pro Pro Ser Pro Glu Phe Glu Thr Glu Thr 
        435                 440                 445             


Leu His Asn Lys Glu Ser Gly Phe Pro Gly Leu Arg Gly Glu Gln Gly 
    450                 455                 460                 


Pro Lys Gly Asn Leu Gly Leu Lys Gly Ile Lys Gly Asp Ser Gly Phe 
465                 470                 475                 480 


Cys Ala Cys Asp Gly Gly Val Pro Asn Thr Gly Pro Pro Gly Glu Pro 
                485                 490                 495     


Gly Pro Pro Gly Pro Trp Gly Leu Ile Gly Leu Pro Gly Leu Lys Gly 
            500                 505                 510         


Ala Arg Gly Asp Arg Gly Ser Gly Gly Ala Gln Gly Pro Ala Gly Ala 
        515                 520                 525             


Pro Gly Leu Val Gly Pro Leu Gly Pro Ser Gly Pro Lys Gly Lys Lys 
    530                 535                 540                 


Gly Glu Pro Ile Leu Ser Thr Ile Gln Gly Met Pro Gly Asp Arg Gly 
545                 550                 555                 560 


Asp Ser Gly Ser Gln Gly Phe Arg Gly Val Ile Gly Glu Pro Gly Lys 
                565                 570                 575     


Asp Gly Val Pro Gly Leu Pro Gly Leu Pro Gly Leu Pro Gly Asp Gly 
            580                 585                 590         


Gly Gln Gly Phe Pro Gly Glu Lys Gly Leu Pro Gly Leu Pro Gly Glu 
        595                 600                 605             


Lys Gly His Pro Gly Pro Pro Gly Leu Pro Gly Asn Gly Leu Pro Gly 
    610                 615                 620                 


Leu Pro Gly Pro Arg Gly Leu Pro Gly Asp Lys Gly Lys Asp Gly Leu 
625                 630                 635                 640 


Pro Gly Gln Gln Gly Leu Pro Gly Ser Lys Gly Ile Thr Leu Pro Cys 
                645                 650                 655     


Ile Ile Pro Gly Ser Tyr Gly Pro Ser Gly Phe Pro Gly Thr Pro Gly 
            660                 665                 670         


Phe Pro Gly Pro Lys Gly Ser Arg Gly Leu Pro Gly Thr Pro Gly Gln 
        675                 680                 685             


Pro Gly Ser Ser Gly Ser Lys Gly Glu Pro Gly Ser Pro Gly Leu Val 
    690                 695                 700                 


His Leu Pro Glu Leu Pro Gly Phe Pro Gly Pro Arg Gly Glu Lys Gly 
705                 710                 715                 720 


Leu Pro Gly Phe Pro Gly Leu Pro Gly Lys Asp Gly Leu Pro Gly Met 
                725                 730                 735     


Ile Gly Ser Pro Gly Leu Pro Gly Ser Lys Gly Ala Thr Gly Asp Ile 
            740                 745                 750         


Phe Gly Ala Glu Asn Gly Ala Pro Gly Glu Gln Gly Leu Gln Gly Leu 
        755                 760                 765             


Thr Gly His Lys Gly Phe Leu Gly Asp Ser Gly Leu Pro Gly Leu Lys 
    770                 775                 780                 


Gly Val His Gly Lys Pro Gly Leu Leu Gly Pro Lys Gly Glu Arg Gly 
785                 790                 795                 800 


Ser Pro Gly Thr Pro Gly Gln Val Gly Gln Pro Gly Thr Pro Gly Ser 
                805                 810                 815     


Ser Gly Pro Tyr Gly Ile Lys Gly Lys Ser Gly Leu Pro Gly Ala Pro 
            820                 825                 830         


Gly Phe Pro Gly Ile Ser Gly His Pro Gly Lys Lys Gly Thr Arg Gly 
        835                 840                 845             


Lys Lys Gly Pro Pro Gly Ser Ile Val Lys Lys Gly Leu Pro Gly Leu 
    850                 855                 860                 


Lys Gly Leu Pro Gly Asn Pro Gly Leu Val Gly Leu Lys Gly Ser Pro 
865                 870                 875                 880 


Gly Ser Pro Gly Val Ala Gly Leu Pro Ala Leu Ser Gly Pro Lys Gly 
                885                 890                 895     


Glu Lys Gly Ser Val Gly Phe Val Gly Phe Pro Gly Ile Pro Gly Leu 
            900                 905                 910         


Pro Gly Ile Pro Gly Thr Arg Gly Leu Lys Gly Ile Pro Gly Ser Thr 
        915                 920                 925             


Gly Lys Met Gly Pro Ser Gly Arg Ala Gly Thr Pro Gly Glu Lys Gly 
    930                 935                 940                 


Asp Arg Gly Asn Pro Gly Pro Val Gly Ile Pro Ser Pro Arg Arg Pro 
945                 950                 955                 960 


Met Ser Asn Leu Trp Leu Lys Gly Asp Lys Gly Ser Gln Gly Ser Ala 
                965                 970                 975     


Gly Ser Asn Gly Phe Pro Gly Pro Arg Gly Asp Lys Gly Glu Ala Gly 
            980                 985                 990         


Arg Pro Gly Pro Pro Gly Leu Pro  Gly Ala Pro Gly Leu  Pro Gly Ile 
        995                 1000                 1005             


Ile Lys  Gly Val Ser Gly Lys  Pro Gly Pro Pro Gly  Phe Met Gly 
    1010                 1015                 1020             


Ile Arg  Gly Leu Pro Gly Leu  Lys Gly Ser Ser Gly  Ile Thr Gly 
    1025                 1030                 1035             


Phe Pro  Gly Met Pro Gly Glu  Ser Gly Ser Gln Gly  Ile Arg Gly 
    1040                 1045                 1050             


Ser Pro  Gly Leu Pro Gly Ala  Ser Gly Leu Pro Gly  Leu Lys Gly 
    1055                 1060                 1065             


Asp Asn  Gly Gln Thr Val Glu  Ile Ser Gly Ser Pro  Gly Pro Lys 
    1070                 1075                 1080             


Gly Gln  Pro Gly Glu Ser Gly  Phe Lys Gly Thr Lys  Gly Arg Asp 
    1085                 1090                 1095             


Gly Leu  Ile Gly Asn Ile Gly  Phe Pro Gly Asn Lys  Gly Glu Asp 
    1100                 1105                 1110             


Gly Lys  Val Gly Val Ser Gly  Asp Val Gly Leu Pro  Gly Ala Pro 
    1115                 1120                 1125             


Gly Phe  Pro Gly Val Ala Gly  Met Arg Gly Glu Pro  Gly Leu Pro 
    1130                 1135                 1140             


Gly Ser  Ser Gly His Gln Gly  Ala Ile Gly Pro Leu  Gly Ser Pro 
    1145                 1150                 1155             


Gly Leu  Ile Gly Pro Lys Gly  Pro Ser Ile Thr Gly  Val Pro Gly 
    1160                 1165                 1170             


Pro Ala  Gly Leu Pro Gly Pro  Lys Gly Glu Lys Gly  Tyr Pro Gly 
    1175                 1180                 1185             


Ile Gly  Ile Gly Ala Pro Gly  Lys Pro Gly Leu Arg  Gly Gln Lys 
    1190                 1195                 1200             


Gly Asp  Arg Gly Phe Pro Gly  Leu Gln Gly Pro Ala  Gly Leu Pro 
    1205                 1210                 1215             


Gly Ala  Pro Gly Ile Ser Leu  Pro Ser Leu Ile Ala  Gly Gln Pro 
    1220                 1225                 1230             


Gly Asp  Pro Gly Arg Pro Gly  Leu Asp Gly Glu Arg  Gly Arg Pro 
    1235                 1240                 1245             


Gly Pro  Ala Gly Pro Pro Gly  Pro Pro Gly Pro Ser  Ser Asn Gln 
    1250                 1255                 1260             


Gly Asp  Thr Gly Asp Pro Gly  Phe Pro Gly Ile Pro  Gly Pro Lys 
    1265                 1270                 1275             


Gly Pro  Lys Gly Asp Gln Gly  Ile Pro Gly Phe Ser  Gly Leu Pro 
    1280                 1285                 1290             


Gly Glu  Leu Gly Leu Lys Gly  Met Arg Gly Glu Pro  Gly Phe Met 
    1295                 1300                 1305             


Gly Thr  Pro Gly Lys Val Gly  Pro Pro Gly Asp Pro  Gly Phe Pro 
    1310                 1315                 1320             


Gly Met  Lys Gly Lys Ala Gly  Pro Arg Gly Ser Ser  Gly Leu Gln 
    1325                 1330                 1335             


Gly Asp  Pro Gly Gln Thr Pro  Thr Ala Glu Ala Val  Gln Val Pro 
    1340                 1345                 1350             


Pro Gly  Pro Leu Gly Leu Pro  Gly Ile Asp Gly Ile  Pro Gly Leu 
    1355                 1360                 1365             


Thr Gly  Asp Pro Gly Ala Gln  Gly Pro Val Gly Leu  Gln Gly Ser 
    1370                 1375                 1380             


Lys Gly  Leu Pro Gly Ile Pro  Gly Lys Asp Gly Pro  Ser Gly Leu 
    1385                 1390                 1395             


Pro Gly  Pro Pro Gly Ala Leu  Gly Asp Pro Gly Leu  Pro Gly Leu 
    1400                 1405                 1410             


Gln Gly  Pro Pro Gly Phe Glu  Gly Ala Pro Gly Gln  Gln Gly Pro 
    1415                 1420                 1425             


Phe Gly  Met Pro Gly Met Pro  Gly Gln Ser Met Arg  Val Gly Tyr 
    1430                 1435                 1440             


Thr Leu  Val Lys His Ser Gln  Ser Glu Gln Val Pro  Pro Cys Pro 
    1445                 1450                 1455             


Ile Gly  Met Ser Gln Leu Trp  Val Gly Tyr Ser Leu  Leu Phe Val 
    1460                 1465                 1470             


Glu Gly  Gln Glu Lys Ala His  Asn Gln Asp Leu Gly  Phe Ala Gly 
    1475                 1480                 1485             


Ser Cys  Leu Pro Arg Phe Ser  Thr Met Pro Phe Ile  Tyr Cys Asn 
    1490                 1495                 1500             


Ile Asn  Glu Val Cys His Tyr  Ala Arg Arg Asn Asp  Lys Ser Tyr 
    1505                 1510                 1515             


Trp Leu  Ser Thr Thr Ala Pro  Ile Pro Met Met Pro  Val Ser Gln 
    1520                 1525                 1530             


Thr Gln  Ile Pro Gln Tyr Ile  Ser Arg Cys Ser Val  Cys Glu Ala 
    1535                 1540                 1545             


Pro Ser  Gln Ala Ile Ala Val  His Ser Gln Asp Ile  Thr Ile Pro 
    1550                 1555                 1560             


Gln Cys  Pro Leu Gly Trp Arg  Ser Leu Trp Ile Gly  Tyr Ser Phe 
    1565                 1570                 1575             


Leu Met  His Thr Ala Ala Gly  Ala Glu Gly Gly Gly  Gln Ser Leu 
    1580                 1585                 1590             


Val Ser  Pro Gly Ser Cys Leu  Glu Asp Phe Arg Ala  Thr Pro Phe 
    1595                 1600                 1605             


Ile Glu  Cys Ser Gly Ala Arg  Gly Thr Cys His Tyr  Phe Ala Asn 
    1610                 1615                 1620             


Lys Tyr  Ser Phe Trp Leu Thr  Thr Val Glu Glu Arg  Gln Gln Phe 
    1625                 1630                 1635             


Gly Glu  Leu Pro Val Ser Glu  Thr Leu Lys Ala Gly  Gln Leu His 
    1640                 1645                 1650             


Thr Arg  Val Ser Arg Cys Gln  Val Cys Met Lys Ser  Leu 
    1655                 1660                 1665     


<210>  3314
<211>  1691
<212>  PRT
<213>  Homo Sapiens

<400>  3314

Met Leu Ile Asn Lys Leu Trp Leu Leu Leu Val Thr Leu Cys Leu Thr 
1               5                   10                  15      


Glu Glu Leu Ala Ala Ala Gly Glu Lys Ser Tyr Gly Lys Pro Cys Gly 
            20                  25                  30          


Gly Gln Asp Cys Ser Gly Ser Cys Gln Cys Phe Pro Glu Lys Gly Ala 
        35                  40                  45              


Arg Gly Arg Pro Gly Pro Ile Gly Ile Gln Gly Pro Thr Gly Pro Gln 
    50                  55                  60                  


Gly Phe Thr Gly Ser Thr Gly Leu Ser Gly Leu Lys Gly Glu Arg Gly 
65                  70                  75                  80  


Phe Pro Gly Leu Leu Gly Pro Tyr Gly Pro Lys Gly Asp Lys Gly Pro 
                85                  90                  95      


Met Gly Val Pro Gly Phe Leu Gly Ile Asn Gly Ile Pro Gly His Pro 
            100                 105                 110         


Gly Gln Pro Gly Pro Arg Gly Pro Pro Gly Leu Asp Gly Cys Asn Gly 
        115                 120                 125             


Thr Gln Gly Ala Val Gly Phe Pro Gly Pro Asp Gly Tyr Pro Gly Leu 
    130                 135                 140                 


Leu Gly Pro Pro Gly Leu Pro Gly Gln Lys Gly Ser Lys Gly Asp Pro 
145                 150                 155                 160 


Val Leu Ala Pro Gly Ser Phe Lys Gly Met Lys Gly Asp Pro Gly Leu 
                165                 170                 175     


Pro Gly Leu Asp Gly Ile Thr Gly Pro Gln Gly Ala Pro Gly Phe Pro 
            180                 185                 190         


Gly Ala Val Gly Pro Ala Gly Pro Pro Gly Leu Gln Gly Pro Pro Gly 
        195                 200                 205             


Pro Pro Gly Pro Leu Gly Pro Asp Gly Asn Met Gly Leu Gly Phe Gln 
    210                 215                 220                 


Gly Glu Lys Gly Val Lys Gly Asp Val Gly Leu Pro Gly Pro Ala Gly 
225                 230                 235                 240 


Pro Pro Pro Ser Thr Gly Glu Leu Glu Phe Met Gly Phe Pro Lys Gly 
                245                 250                 255     


Lys Lys Gly Ser Lys Gly Glu Pro Gly Pro Lys Gly Phe Pro Gly Ile 
            260                 265                 270         


Ser Gly Pro Pro Gly Phe Pro Gly Leu Gly Thr Thr Gly Glu Lys Gly 
        275                 280                 285             


Glu Lys Gly Glu Lys Gly Ile Pro Gly Leu Pro Gly Pro Arg Gly Pro 
    290                 295                 300                 


Met Gly Ser Glu Gly Val Gln Gly Pro Pro Gly Gln Gln Gly Lys Lys 
305                 310                 315                 320 


Gly Thr Leu Gly Phe Pro Gly Leu Asn Gly Phe Gln Gly Ile Glu Gly 
                325                 330                 335     


Gln Lys Gly Asp Ile Gly Leu Pro Gly Pro Asp Val Phe Ile Asp Ile 
            340                 345                 350         


Asp Gly Ala Val Ile Ser Gly Asn Pro Gly Asp Pro Gly Val Pro Gly 
        355                 360                 365             


Leu Pro Gly Leu Lys Gly Asp Glu Gly Ile Gln Gly Leu Arg Gly Pro 
    370                 375                 380                 


Ser Gly Val Pro Gly Leu Pro Ala Leu Ser Gly Val Pro Gly Ala Leu 
385                 390                 395                 400 


Gly Pro Gln Gly Phe Pro Gly Leu Lys Gly Asp Gln Gly Asn Pro Gly 
                405                 410                 415     


Arg Thr Thr Ile Gly Ala Ala Gly Leu Pro Gly Arg Asp Gly Leu Pro 
            420                 425                 430         


Gly Pro Pro Gly Pro Pro Gly Pro Pro Ser Pro Glu Phe Glu Thr Glu 
        435                 440                 445             


Thr Leu His Asn Lys Glu Ser Gly Phe Pro Gly Leu Arg Gly Glu Gln 
    450                 455                 460                 


Gly Pro Lys Gly Asn Leu Gly Leu Lys Gly Ile Lys Gly Asp Ser Gly 
465                 470                 475                 480 


Phe Cys Ala Cys Asp Gly Gly Val Pro Asn Thr Gly Pro Pro Gly Glu 
                485                 490                 495     


Pro Gly Pro Pro Gly Pro Trp Gly Leu Ile Gly Leu Pro Gly Leu Lys 
            500                 505                 510         


Gly Ala Arg Gly Asp Arg Gly Ser Gly Gly Ala Gln Gly Pro Ala Gly 
        515                 520                 525             


Ala Pro Gly Leu Val Gly Pro Leu Gly Pro Ser Gly Pro Lys Gly Lys 
    530                 535                 540                 


Lys Gly Glu Pro Ile Leu Ser Thr Ile Gln Gly Met Pro Gly Asp Arg 
545                 550                 555                 560 


Gly Asp Ser Gly Ser Gln Gly Phe Arg Gly Val Ile Gly Glu Pro Gly 
                565                 570                 575     


Lys Asp Gly Val Pro Gly Leu Pro Gly Leu Pro Gly Leu Pro Gly Asp 
            580                 585                 590         


Gly Gly Gln Gly Phe Pro Gly Glu Lys Gly Leu Pro Gly Leu Pro Gly 
        595                 600                 605             


Glu Lys Gly His Pro Gly Pro Pro Gly Leu Pro Gly Asn Gly Leu Pro 
    610                 615                 620                 


Gly Leu Pro Gly Pro Arg Gly Leu Pro Gly Asp Lys Gly Lys Asp Gly 
625                 630                 635                 640 


Leu Pro Gly Gln Gln Gly Leu Pro Gly Ser Lys Gly Ile Thr Leu Pro 
                645                 650                 655     


Cys Ile Ile Pro Gly Ser Tyr Gly Pro Ser Gly Phe Pro Gly Thr Pro 
            660                 665                 670         


Gly Phe Pro Gly Pro Lys Gly Ser Arg Gly Leu Pro Gly Thr Pro Gly 
        675                 680                 685             


Gln Pro Gly Ser Ser Gly Ser Lys Gly Glu Pro Gly Ser Pro Gly Leu 
    690                 695                 700                 


Val His Leu Pro Glu Leu Pro Gly Phe Pro Gly Pro Arg Gly Glu Lys 
705                 710                 715                 720 


Gly Leu Pro Gly Phe Pro Gly Leu Pro Gly Lys Asp Gly Leu Pro Gly 
                725                 730                 735     


Met Ile Gly Ser Pro Gly Leu Pro Gly Ser Lys Gly Ala Thr Gly Asp 
            740                 745                 750         


Ile Phe Gly Ala Glu Asn Gly Ala Pro Gly Glu Gln Gly Leu Gln Gly 
        755                 760                 765             


Leu Thr Gly His Lys Gly Phe Leu Gly Asp Ser Gly Leu Pro Gly Leu 
    770                 775                 780                 


Lys Gly Val His Gly Lys Pro Gly Leu Leu Gly Pro Lys Gly Glu Arg 
785                 790                 795                 800 


Gly Ser Pro Gly Thr Pro Gly Gln Val Gly Gln Pro Gly Thr Pro Gly 
                805                 810                 815     


Ser Ser Gly Pro Tyr Gly Ile Lys Gly Lys Ser Gly Leu Pro Gly Ala 
            820                 825                 830         


Pro Gly Phe Pro Gly Ile Ser Gly His Pro Gly Lys Lys Gly Thr Arg 
        835                 840                 845             


Gly Lys Lys Gly Pro Pro Gly Ser Ile Val Lys Lys Gly Leu Pro Gly 
    850                 855                 860                 


Leu Lys Gly Leu Pro Gly Asn Pro Gly Leu Val Gly Leu Lys Gly Ser 
865                 870                 875                 880 


Pro Gly Ser Pro Gly Val Ala Gly Leu Pro Ala Leu Ser Gly Pro Lys 
                885                 890                 895     


Gly Glu Lys Gly Ser Val Gly Phe Val Gly Phe Pro Gly Ile Pro Gly 
            900                 905                 910         


Leu Pro Gly Ile Pro Gly Thr Arg Gly Leu Lys Gly Ile Pro Gly Ser 
        915                 920                 925             


Thr Gly Lys Met Gly Pro Ser Gly Arg Ala Gly Thr Pro Gly Glu Lys 
    930                 935                 940                 


Gly Asp Arg Gly Asn Pro Gly Pro Val Gly Ile Pro Ser Pro Arg Arg 
945                 950                 955                 960 


Pro Met Ser Asn Leu Trp Leu Lys Gly Asp Lys Gly Ser Gln Gly Ser 
                965                 970                 975     


Ala Gly Ser Asn Gly Phe Pro Gly Pro Arg Gly Asp Lys Gly Glu Ala 
            980                 985                 990         


Gly Arg Pro Gly Pro Pro Gly Leu  Pro Gly Ala Pro Gly  Leu Pro Gly 
        995                 1000                 1005             


Ile Ile  Lys Gly Val Ser Gly  Lys Pro Gly Pro Pro  Gly Phe Met 
    1010                 1015                 1020             


Gly Ile  Arg Gly Leu Pro Gly  Leu Lys Gly Ser Ser  Gly Ile Thr 
    1025                 1030                 1035             


Gly Phe  Pro Gly Met Pro Gly  Glu Ser Gly Ser Gln  Gly Ile Arg 
    1040                 1045                 1050             


Gly Ser  Pro Gly Leu Pro Gly  Ala Ser Gly Leu Pro  Gly Leu Lys 
    1055                 1060                 1065             


Gly Asp  Asn Gly Gln Thr Val  Glu Ile Ser Gly Ser  Pro Gly Pro 
    1070                 1075                 1080             


Lys Gly  Gln Pro Gly Glu Ser  Gly Phe Lys Gly Thr  Lys Gly Arg 
    1085                 1090                 1095             


Asp Gly  Leu Ile Gly Asn Ile  Gly Phe Pro Gly Asn  Lys Gly Glu 
    1100                 1105                 1110             


Asp Gly  Lys Val Gly Val Ser  Gly Asp Val Gly Leu  Pro Gly Ala 
    1115                 1120                 1125             


Pro Gly  Phe Pro Gly Val Ala  Gly Met Arg Gly Glu  Pro Gly Leu 
    1130                 1135                 1140             


Pro Gly  Ser Ser Gly His Gln  Gly Ala Ile Gly Pro  Leu Gly Ser 
    1145                 1150                 1155             


Pro Gly  Leu Ile Gly Pro Lys  Gly Phe Pro Gly Phe  Pro Gly Leu 
    1160                 1165                 1170             


His Gly  Leu Asn Gly Leu Pro  Gly Thr Lys Gly Thr  His Gly Thr 
    1175                 1180                 1185             


Pro Gly  Pro Ser Ile Thr Gly  Val Pro Gly Pro Ala  Gly Leu Pro 
    1190                 1195                 1200             


Gly Pro  Lys Gly Glu Lys Gly  Tyr Pro Gly Ile Gly  Ile Gly Ala 
    1205                 1210                 1215             


Pro Gly  Lys Pro Gly Leu Arg  Gly Gln Lys Gly Asp  Arg Gly Phe 
    1220                 1225                 1230             


Pro Gly  Leu Gln Gly Pro Ala  Gly Leu Pro Gly Ala  Pro Gly Ile 
    1235                 1240                 1245             


Ser Leu  Pro Ser Leu Ile Ala  Gly Gln Pro Gly Asp  Pro Gly Arg 
    1250                 1255                 1260             


Pro Gly  Leu Asp Gly Glu Arg  Gly Arg Pro Gly Pro  Ala Gly Pro 
    1265                 1270                 1275             


Pro Gly  Pro Pro Gly Pro Ser  Ser Asn Gln Gly Asp  Thr Gly Asp 
    1280                 1285                 1290             


Pro Gly  Phe Pro Gly Ile Pro  Gly Pro Lys Gly Pro  Lys Gly Asp 
    1295                 1300                 1305             


Gln Gly  Ile Pro Gly Phe Ser  Gly Leu Pro Gly Glu  Leu Gly Leu 
    1310                 1315                 1320             


Lys Gly  Met Arg Gly Glu Pro  Gly Phe Met Gly Thr  Pro Gly Lys 
    1325                 1330                 1335             


Val Gly  Pro Pro Gly Asp Pro  Gly Phe Pro Gly Met  Lys Gly Lys 
    1340                 1345                 1350             


Ala Gly  Pro Arg Gly Ser Ser  Gly Leu Gln Gly Asp  Pro Gly Gln 
    1355                 1360                 1365             


Thr Pro  Thr Ala Glu Ala Val  Gln Val Pro Pro Gly  Pro Leu Gly 
    1370                 1375                 1380             


Leu Pro  Gly Ile Asp Gly Ile  Pro Gly Leu Thr Gly  Asp Pro Gly 
    1385                 1390                 1395             


Ala Gln  Gly Pro Val Gly Leu  Gln Gly Ser Lys Gly  Leu Pro Gly 
    1400                 1405                 1410             


Ile Pro  Gly Lys Asp Gly Pro  Ser Gly Leu Pro Gly  Pro Pro Gly 
    1415                 1420                 1425             


Ala Leu  Gly Asp Pro Gly Leu  Pro Gly Leu Gln Gly  Pro Pro Gly 
    1430                 1435                 1440             


Phe Glu  Gly Ala Pro Gly Gln  Gln Gly Pro Phe Gly  Met Pro Gly 
    1445                 1450                 1455             


Met Pro  Gly Gln Ser Met Arg  Val Gly Tyr Thr Leu  Val Lys His 
    1460                 1465                 1470             


Ser Gln  Ser Glu Gln Val Pro  Pro Cys Pro Ile Gly  Met Ser Gln 
    1475                 1480                 1485             


Leu Trp  Val Gly Tyr Ser Leu  Leu Phe Val Glu Gly  Gln Glu Lys 
    1490                 1495                 1500             


Ala His  Asn Gln Asp Leu Gly  Phe Ala Gly Ser Cys  Leu Pro Arg 
    1505                 1510                 1515             


Phe Ser  Thr Met Pro Phe Ile  Tyr Cys Asn Ile Asn  Glu Val Cys 
    1520                 1525                 1530             


His Tyr  Ala Arg Arg Asn Asp  Lys Ser Tyr Trp Leu  Ser Thr Thr 
    1535                 1540                 1545             


Ala Pro  Ile Pro Met Met Pro  Val Ser Gln Thr Gln  Ile Pro Gln 
    1550                 1555                 1560             


Tyr Ile  Ser Arg Cys Ser Val  Cys Glu Ala Pro Ser  Gln Ala Ile 
    1565                 1570                 1575             


Ala Val  His Ser Gln Asp Ile  Thr Ile Pro Gln Cys  Pro Leu Gly 
    1580                 1585                 1590             


Trp Arg  Ser Leu Trp Ile Gly  Tyr Ser Phe Leu Met  His Thr Ala 
    1595                 1600                 1605             


Ala Gly  Ala Glu Gly Gly Gly  Gln Ser Leu Val Ser  Pro Gly Ser 
    1610                 1615                 1620             


Cys Leu  Glu Asp Phe Arg Ala  Thr Pro Phe Ile Glu  Cys Ser Gly 
    1625                 1630                 1635             


Ala Arg  Gly Thr Cys His Tyr  Phe Ala Asn Lys Tyr  Ser Phe Trp 
    1640                 1645                 1650             


Leu Thr  Thr Val Glu Glu Arg  Gln Gln Phe Gly Glu  Leu Pro Val 
    1655                 1660                 1665             


Ser Glu  Thr Leu Lys Ala Gly  Gln Leu His Thr Arg  Val Ser Arg 
    1670                 1675                 1680             


Cys Gln  Val Cys Met Lys Ser  Leu 
    1685                 1690     


<210>  3315
<211>  1838
<212>  PRT
<213>  Homo Sapiens

<400>  3315

Met Asp Val His Thr Arg Trp Lys Ala Arg Ser Ala Leu Arg Pro Gly 
1               5                   10                  15      


Ala Pro Leu Leu Pro Pro Leu Leu Leu Leu Leu Leu Trp Ala Pro Pro 
            20                  25                  30          


Pro Ser Arg Ala Ala Gln Pro Ala Asp Leu Leu Lys Val Leu Asp Phe 
        35                  40                  45              


His Asn Leu Pro Asp Gly Ile Thr Lys Thr Thr Gly Phe Cys Ala Thr 
    50                  55                  60                  


Arg Arg Ser Ser Lys Gly Pro Asp Val Ala Tyr Arg Val Thr Lys Asp 
65                  70                  75                  80  


Ala Gln Leu Ser Ala Pro Thr Lys Gln Leu Tyr Pro Ala Ser Ala Phe 
                85                  90                  95      


Pro Glu Asp Phe Ser Ile Leu Thr Thr Val Lys Ala Lys Lys Gly Ser 
            100                 105                 110         


Gln Ala Phe Leu Val Ser Ile Tyr Asn Glu Gln Gly Ile Gln Gln Ile 
        115                 120                 125             


Gly Leu Glu Leu Gly Arg Ser Pro Val Phe Leu Tyr Glu Asp His Thr 
    130                 135                 140                 


Gly Lys Pro Gly Pro Glu Asp Tyr Pro Leu Phe Arg Gly Ile Asn Leu 
145                 150                 155                 160 


Ser Asp Gly Lys Trp His Arg Ile Ala Leu Ser Val His Lys Lys Asn 
                165                 170                 175     


Val Thr Leu Ile Leu Asp Cys Lys Lys Lys Thr Thr Lys Phe Leu Asp 
            180                 185                 190         


Arg Ser Asp His Pro Met Ile Asp Ile Asn Gly Ile Ile Val Phe Gly 
        195                 200                 205             


Thr Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Ile Gln Gln Leu 
    210                 215                 220                 


Leu Phe Val Ser Asp His Arg Ala Ala Tyr Asp Tyr Cys Glu His Tyr 
225                 230                 235                 240 


Ser Pro Asp Cys Asp Thr Ala Val Pro Asp Thr Pro Gln Ser Gln Asp 
                245                 250                 255     


Pro Asn Pro Asp Glu Tyr Tyr Thr Glu Gly Asp Gly Glu Gly Glu Thr 
            260                 265                 270         


Tyr Tyr Tyr Glu Tyr Pro Tyr Tyr Glu Asp Pro Glu Asp Leu Gly Lys 
        275                 280                 285             


Glu Pro Thr Pro Ser Lys Lys Pro Val Glu Ala Ala Lys Glu Thr Thr 
    290                 295                 300                 


Glu Val Pro Glu Glu Leu Thr Pro Thr Pro Thr Glu Ala Ala Pro Met 
305                 310                 315                 320 


Pro Glu Thr Ser Glu Gly Ala Gly Lys Glu Glu Asp Val Gly Ile Gly 
                325                 330                 335     


Asp Tyr Asp Tyr Val Pro Ser Glu Asp Tyr Tyr Thr Pro Ser Pro Tyr 
            340                 345                 350         


Asp Asp Leu Thr Tyr Gly Glu Gly Glu Glu Asn Pro Asp Gln Pro Thr 
        355                 360                 365             


Asp Pro Gly Ala Gly Ala Glu Ile Pro Thr Ser Thr Ala Asp Thr Ser 
    370                 375                 380                 


Asn Ser Ser Asn Pro Ala Pro Pro Pro Gly Glu Gly Ala Asp Asp Leu 
385                 390                 395                 400 


Glu Gly Glu Phe Thr Glu Glu Thr Ile Arg Asn Leu Asp Glu Asn Tyr 
                405                 410                 415     


Tyr Asp Pro Tyr Tyr Asp Pro Thr Ser Ser Pro Ser Glu Ile Gly Pro 
            420                 425                 430         


Gly Met Pro Ala Asn Gln Asp Thr Ile Tyr Glu Gly Ile Gly Gly Pro 
        435                 440                 445             


Arg Gly Glu Lys Gly Gln Lys Gly Glu Pro Ala Ile Ile Glu Pro Gly 
    450                 455                 460                 


Met Leu Ile Glu Gly Pro Pro Gly Pro Glu Gly Pro Ala Gly Leu Pro 
465                 470                 475                 480 


Gly Pro Pro Gly Thr Met Gly Pro Thr Gly Gln Val Gly Asp Pro Gly 
                485                 490                 495     


Glu Arg Gly Pro Pro Gly Arg Pro Gly Leu Pro Gly Ala Asp Gly Leu 
            500                 505                 510         


Pro Gly Pro Pro Gly Thr Met Leu Met Leu Pro Phe Arg Phe Gly Gly 
        515                 520                 525             


Gly Gly Asp Ala Gly Ser Lys Gly Pro Met Val Ser Ala Gln Glu Ser 
    530                 535                 540                 


Gln Ala Gln Ala Ile Leu Gln Gln Ala Arg Leu Ala Leu Arg Gly Pro 
545                 550                 555                 560 


Ala Gly Pro Met Gly Leu Thr Gly Arg Pro Gly Pro Val Gly Pro Pro 
                565                 570                 575     


Gly Ser Gly Gly Leu Lys Gly Glu Pro Gly Asp Val Gly Pro Gln Gly 
            580                 585                 590         


Pro Arg Gly Val Gln Gly Pro Pro Gly Pro Ala Gly Lys Pro Gly Arg 
        595                 600                 605             


Arg Gly Arg Ala Gly Ser Asp Gly Ala Arg Gly Met Pro Gly Gln Thr 
    610                 615                 620                 


Gly Pro Lys Gly Asp Arg Gly Phe Asp Gly Leu Ala Gly Leu Pro Gly 
625                 630                 635                 640 


Glu Lys Gly His Arg Gly Asp Pro Gly Pro Ser Gly Pro Pro Gly Pro 
                645                 650                 655     


Pro Gly Asp Asp Gly Glu Arg Gly Asp Asp Gly Glu Val Gly Pro Arg 
            660                 665                 670         


Gly Leu Pro Gly Glu Pro Gly Pro Arg Gly Leu Leu Gly Pro Lys Gly 
        675                 680                 685             


Pro Pro Gly Pro Pro Gly Pro Pro Gly Val Thr Gly Met Asp Gly Gln 
    690                 695                 700                 


Pro Gly Pro Lys Gly Asn Val Gly Pro Gln Gly Glu Pro Gly Pro Pro 
705                 710                 715                 720 


Gly Gln Gln Gly Asn Pro Gly Ala Gln Gly Leu Pro Gly Pro Gln Gly 
                725                 730                 735     


Ala Ile Gly Pro Pro Gly Glu Lys Gly Pro Leu Gly Lys Pro Gly Leu 
            740                 745                 750         


Pro Gly Met Pro Gly Ala Asp Gly Pro Pro Gly His Pro Gly Lys Glu 
        755                 760                 765             


Gly Pro Pro Gly Glu Lys Gly Gly Gln Gly Pro Pro Gly Pro Gln Gly 
    770                 775                 780                 


Pro Ile Gly Tyr Pro Gly Pro Arg Gly Val Lys Gly Ala Asp Gly Ile 
785                 790                 795                 800 


Arg Gly Leu Lys Gly Thr Lys Gly Glu Lys Gly Glu Asp Gly Phe Pro 
                805                 810                 815     


Gly Phe Lys Gly Asp Met Gly Ile Lys Gly Asp Arg Gly Glu Ile Gly 
            820                 825                 830         


Pro Pro Gly Pro Arg Gly Glu Asp Gly Pro Glu Gly Pro Lys Gly Arg 
        835                 840                 845             


Gly Gly Pro Asn Gly Asp Pro Gly Pro Leu Gly Pro Pro Gly Glu Lys 
    850                 855                 860                 


Gly Lys Leu Gly Val Pro Gly Leu Pro Gly Tyr Pro Gly Arg Gln Gly 
865                 870                 875                 880 


Pro Lys Gly Ser Ile Gly Phe Pro Gly Phe Pro Gly Ala Asn Gly Glu 
                885                 890                 895     


Lys Gly Gly Arg Gly Thr Pro Gly Lys Pro Gly Pro Arg Gly Gln Arg 
            900                 905                 910         


Gly Pro Thr Gly Pro Arg Gly Glu Arg Gly Pro Arg Gly Ile Thr Gly 
        915                 920                 925             


Lys Pro Gly Pro Lys Gly Asn Ser Gly Gly Asp Gly Pro Ala Gly Pro 
    930                 935                 940                 


Pro Gly Glu Arg Gly Pro Asn Gly Pro Gln Gly Pro Thr Gly Phe Pro 
945                 950                 955                 960 


Gly Pro Lys Gly Pro Pro Gly Pro Pro Gly Lys Asp Gly Leu Pro Gly 
                965                 970                 975     


His Pro Gly Gln Arg Gly Glu Thr Gly Phe Gln Gly Lys Thr Gly Pro 
            980                 985                 990         


Pro Gly Pro Pro Gly Val Val Gly  Pro Gln Gly Pro Thr  Gly Glu Thr 
        995                 1000                 1005             


Gly Pro  Met Gly Glu Arg Gly  His Pro Gly Pro Pro  Gly Pro Pro 
    1010                 1015                 1020             


Gly Glu  Gln Gly Leu Pro Gly  Leu Ala Gly Lys Glu  Gly Thr Lys 
    1025                 1030                 1035             


Gly Asp  Pro Gly Pro Ala Gly  Leu Pro Gly Lys Asp  Gly Pro Pro 
    1040                 1045                 1050             


Gly Leu  Arg Gly Phe Pro Gly  Asp Arg Gly Leu Pro  Gly Pro Val 
    1055                 1060                 1065             


Gly Ala  Leu Gly Leu Lys Gly  Asn Glu Gly Pro Pro  Gly Pro Pro 
    1070                 1075                 1080             


Gly Pro  Ala Gly Ser Pro Gly  Glu Arg Gly Pro Ala  Gly Ala Ala 
    1085                 1090                 1095             


Gly Pro  Ile Gly Ile Pro Gly  Arg Pro Gly Pro Gln  Gly Pro Pro 
    1100                 1105                 1110             


Gly Pro  Ala Gly Glu Lys Gly  Ala Pro Gly Glu Lys  Gly Pro Gln 
    1115                 1120                 1125             


Gly Pro  Ala Gly Arg Asp Gly  Leu Gln Gly Pro Val  Gly Leu Pro 
    1130                 1135                 1140             


Gly Pro  Ala Gly Pro Val Gly  Pro Pro Gly Glu Asp  Gly Asp Lys 
    1145                 1150                 1155             


Gly Glu  Ile Gly Glu Pro Gly  Gln Lys Gly Ser Lys  Gly Asp Lys 
    1160                 1165                 1170             


Gly Glu  Gln Gly Pro Pro Gly  Pro Thr Gly Pro Gln  Gly Pro Ile 
    1175                 1180                 1185             


Gly Gln  Pro Gly Pro Ser Gly  Ala Asp Gly Glu Pro  Gly Pro Arg 
    1190                 1195                 1200             


Gly Gln  Gln Gly Leu Phe Gly  Gln Lys Gly Asp Glu  Gly Pro Arg 
    1205                 1210                 1215             


Gly Phe  Pro Gly Pro Pro Gly  Pro Val Gly Leu Gln  Gly Leu Pro 
    1220                 1225                 1230             


Gly Pro  Pro Gly Glu Lys Gly  Glu Thr Gly Asp Val  Gly Gln Met 
    1235                 1240                 1245             


Gly Pro  Pro Gly Pro Pro Gly  Pro Arg Gly Pro Ser  Gly Ala Pro 
    1250                 1255                 1260             


Gly Ala  Asp Gly Pro Gln Gly  Pro Pro Gly Gly Ile  Gly Asn Pro 
    1265                 1270                 1275             


Gly Ala  Val Gly Glu Lys Gly  Glu Pro Gly Glu Ala  Gly Glu Pro 
    1280                 1285                 1290             


Gly Leu  Pro Gly Glu Gly Gly  Pro Pro Gly Pro Lys  Gly Glu Arg 
    1295                 1300                 1305             


Gly Glu  Lys Gly Glu Ser Gly  Pro Ser Gly Ala Ala  Gly Pro Pro 
    1310                 1315                 1320             


Gly Pro  Lys Gly Pro Pro Gly  Asp Asp Gly Pro Lys  Gly Ser Pro 
    1325                 1330                 1335             


Gly Pro  Val Gly Phe Pro Gly  Asp Pro Gly Pro Pro  Gly Glu Pro 
    1340                 1345                 1350             


Gly Pro  Ala Gly Gln Asp Gly  Pro Pro Gly Asp Lys  Gly Asp Asp 
    1355                 1360                 1365             


Gly Glu  Pro Gly Gln Thr Gly  Ser Pro Gly Pro Thr  Gly Glu Pro 
    1370                 1375                 1380             


Gly Pro  Ser Gly Pro Pro Gly  Lys Arg Gly Pro Pro  Gly Pro Ala 
    1385                 1390                 1395             


Gly Pro  Glu Gly Arg Gln Gly  Glu Lys Gly Ala Lys  Gly Glu Ala 
    1400                 1405                 1410             


Gly Leu  Glu Gly Pro Pro Gly  Lys Thr Gly Pro Ile  Gly Pro Gln 
    1415                 1420                 1425             


Gly Ala  Pro Gly Lys Pro Gly  Pro Asp Gly Leu Arg  Gly Ile Pro 
    1430                 1435                 1440             


Gly Pro  Val Gly Glu Gln Gly  Leu Pro Gly Ser Pro  Gly Pro Asp 
    1445                 1450                 1455             


Gly Pro  Pro Gly Pro Met Gly  Pro Pro Gly Leu Pro  Gly Leu Lys 
    1460                 1465                 1470             


Gly Asp  Ser Gly Pro Lys Gly  Glu Lys Gly His Pro  Gly Leu Ile 
    1475                 1480                 1485             


Gly Leu  Ile Gly Pro Pro Gly  Glu Gln Gly Glu Lys  Gly Asp Arg 
    1490                 1495                 1500             


Gly Leu  Pro Gly Pro Gln Gly  Ser Ser Gly Pro Lys  Gly Glu Gln 
    1505                 1510                 1515             


Gly Ile  Thr Gly Pro Ser Gly  Pro Ile Gly Pro Pro  Gly Pro Pro 
    1520                 1525                 1530             


Gly Leu  Pro Gly Pro Pro Gly  Pro Lys Gly Ala Lys  Gly Ser Ser 
    1535                 1540                 1545             


Gly Pro  Thr Gly Pro Lys Gly  Glu Ala Gly His Pro  Gly Pro Pro 
    1550                 1555                 1560             


Gly Pro  Pro Gly Pro Pro Gly  Glu Val Ile Gln Pro  Leu Pro Ile 
    1565                 1570                 1575             


Gln Ala  Ser Arg Thr Arg Arg  Asn Ile Asp Ala Ser  Gln Leu Leu 
    1580                 1585                 1590             


Asp Asp  Gly Asn Gly Glu Asn  Tyr Val Asp Tyr Ala  Asp Gly Met 
    1595                 1600                 1605             


Glu Glu  Ile Phe Gly Ser Leu  Asn Ser Leu Lys Leu  Glu Ile Glu 
    1610                 1615                 1620             


Gln Met  Lys Arg Pro Leu Gly  Thr Gln Gln Asn Pro  Ala Arg Thr 
    1625                 1630                 1635             


Cys Lys  Asp Leu Gln Leu Cys  His Pro Asp Phe Pro  Asp Gly Glu 
    1640                 1645                 1650             


Tyr Trp  Val Asp Pro Asn Gln  Gly Cys Ser Arg Asp  Ser Phe Lys 
    1655                 1660                 1665             


Val Tyr  Cys Asn Phe Thr Ala  Gly Gly Ser Thr Cys  Val Phe Pro 
    1670                 1675                 1680             


Asp Lys  Lys Ser Glu Gly Ala  Arg Ile Thr Ser Trp  Pro Lys Glu 
    1685                 1690                 1695             


Asn Pro  Gly Ser Trp Phe Ser  Glu Phe Lys Arg Gly  Lys Leu Leu 
    1700                 1705                 1710             


Ser Tyr  Val Asp Ala Glu Gly  Asn Pro Val Gly Val  Val Gln Met 
    1715                 1720                 1725             


Thr Phe  Leu Arg Leu Leu Ser  Ala Ser Ala His Gln  Asn Val Thr 
    1730                 1735                 1740             


Tyr His  Cys Tyr Gln Ser Val  Ala Trp Gln Asp Ala  Ala Thr Gly 
    1745                 1750                 1755             


Ser Tyr  Asp Lys Ala Leu Arg  Phe Leu Gly Ser Asn  Asp Glu Glu 
    1760                 1765                 1770             


Met Ser  Tyr Asp Asn Asn Pro  Tyr Ile Arg Ala Leu  Val Asp Gly 
    1775                 1780                 1785             


Cys Ala  Thr Lys Lys Gly Tyr  Gln Lys Thr Val Leu  Glu Ile Asp 
    1790                 1795                 1800             


Thr Pro  Lys Val Glu Gln Val  Pro Ile Val Asp Ile  Met Phe Asn 
    1805                 1810                 1815             


Asp Phe  Gly Glu Ala Ser Gln  Lys Phe Gly Phe Glu  Val Gly Pro 
    1820                 1825                 1830             


Ala Cys  Phe Met Gly 
    1835             


<210>  3316
<211>  1838
<212>  PRT
<213>  Homo Sapiens

<400>  3316

Met Asp Val His Thr Arg Trp Lys Ala Arg Ser Ala Leu Arg Pro Gly 
1               5                   10                  15      


Ala Pro Leu Leu Pro Pro Leu Leu Leu Leu Leu Leu Trp Ala Pro Pro 
            20                  25                  30          


Pro Ser Arg Ala Ala Gln Pro Ala Asp Leu Leu Lys Val Leu Asp Phe 
        35                  40                  45              


His Asn Leu Pro Asp Gly Ile Thr Lys Thr Thr Gly Phe Cys Ala Thr 
    50                  55                  60                  


Arg Arg Ser Ser Lys Gly Pro Asp Val Ala Tyr Arg Val Thr Lys Asp 
65                  70                  75                  80  


Ala Gln Leu Ser Ala Pro Thr Lys Gln Leu Tyr Pro Ala Ser Ala Phe 
                85                  90                  95      


Pro Glu Asp Phe Ser Ile Leu Thr Thr Val Lys Ala Lys Lys Gly Ser 
            100                 105                 110         


Gln Ala Phe Leu Val Ser Ile Tyr Asn Glu Gln Gly Ile Gln Gln Ile 
        115                 120                 125             


Gly Leu Glu Leu Gly Arg Ser Pro Val Phe Leu Tyr Glu Asp His Thr 
    130                 135                 140                 


Gly Lys Pro Gly Pro Glu Asp Tyr Pro Leu Phe Arg Gly Ile Asn Leu 
145                 150                 155                 160 


Ser Asp Gly Lys Trp His Arg Ile Ala Leu Ser Val His Lys Lys Asn 
                165                 170                 175     


Val Thr Leu Ile Leu Asp Cys Lys Lys Lys Thr Thr Lys Phe Leu Asp 
            180                 185                 190         


Arg Ser Asp His Pro Met Ile Asp Ile Asn Gly Ile Ile Val Phe Gly 
        195                 200                 205             


Thr Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Ile Gln Gln Leu 
    210                 215                 220                 


Leu Phe Val Ser Asp His Arg Ala Ala Tyr Asp Tyr Cys Glu His Tyr 
225                 230                 235                 240 


Ser Pro Asp Cys Asp Thr Ala Val Pro Asp Thr Pro Gln Ser Gln Asp 
                245                 250                 255     


Pro Asn Pro Asp Glu Tyr Tyr Thr Glu Gly Asp Gly Glu Gly Glu Thr 
            260                 265                 270         


Tyr Tyr Tyr Glu Tyr Pro Tyr Tyr Glu Asp Pro Glu Asp Leu Gly Lys 
        275                 280                 285             


Glu Pro Thr Pro Ser Lys Lys Pro Val Glu Ala Ala Lys Glu Thr Thr 
    290                 295                 300                 


Glu Val Pro Glu Glu Leu Thr Pro Thr Pro Thr Glu Ala Ala Pro Met 
305                 310                 315                 320 


Pro Glu Thr Ser Glu Gly Ala Gly Lys Glu Glu Asp Val Gly Ile Gly 
                325                 330                 335     


Asp Tyr Asp Tyr Val Pro Ser Glu Asp Tyr Tyr Thr Pro Ser Pro Tyr 
            340                 345                 350         


Asp Asp Leu Thr Tyr Gly Glu Gly Glu Glu Asn Pro Asp Gln Pro Thr 
        355                 360                 365             


Asp Pro Gly Ala Gly Ala Glu Ile Pro Thr Ser Thr Ala Asp Thr Ser 
    370                 375                 380                 


Asn Ser Ser Asn Pro Ala Pro Pro Pro Gly Glu Gly Ala Asp Asp Leu 
385                 390                 395                 400 


Glu Gly Glu Phe Thr Glu Glu Thr Ile Arg Asn Leu Asp Glu Asn Tyr 
                405                 410                 415     


Tyr Asp Pro Tyr Tyr Asp Pro Thr Ser Ser Pro Ser Glu Ile Gly Pro 
            420                 425                 430         


Gly Met Pro Ala Asn Gln Asp Thr Ile Tyr Glu Gly Ile Gly Gly Pro 
        435                 440                 445             


Arg Gly Glu Lys Gly Gln Lys Gly Glu Pro Ala Ile Ile Glu Pro Gly 
    450                 455                 460                 


Met Leu Ile Glu Gly Pro Pro Gly Pro Glu Gly Pro Ala Gly Leu Pro 
465                 470                 475                 480 


Gly Pro Pro Gly Thr Met Gly Pro Thr Gly Gln Val Gly Asp Pro Gly 
                485                 490                 495     


Glu Arg Gly Pro Pro Gly Arg Pro Gly Leu Pro Gly Ala Asp Gly Leu 
            500                 505                 510         


Pro Gly Pro Pro Gly Thr Met Leu Met Leu Pro Phe Arg Phe Gly Gly 
        515                 520                 525             


Gly Gly Asp Ala Gly Ser Lys Gly Pro Met Val Ser Ala Gln Glu Ser 
    530                 535                 540                 


Gln Ala Gln Ala Ile Leu Gln Gln Ala Arg Leu Ala Leu Arg Gly Pro 
545                 550                 555                 560 


Ala Gly Pro Met Gly Leu Thr Gly Arg Pro Gly Pro Val Gly Pro Pro 
                565                 570                 575     


Gly Ser Gly Gly Leu Lys Gly Glu Pro Gly Asp Val Gly Pro Gln Gly 
            580                 585                 590         


Pro Arg Gly Val Gln Gly Pro Pro Gly Pro Ala Gly Lys Pro Gly Arg 
        595                 600                 605             


Arg Gly Arg Ala Gly Ser Asp Gly Ala Arg Gly Met Pro Gly Gln Thr 
    610                 615                 620                 


Gly Pro Lys Gly Asp Arg Gly Phe Asp Gly Leu Ala Gly Leu Pro Gly 
625                 630                 635                 640 


Glu Lys Gly His Arg Gly Asp Pro Gly Pro Ser Gly Pro Pro Gly Pro 
                645                 650                 655     


Pro Gly Asp Asp Gly Glu Arg Gly Asp Asp Gly Glu Val Gly Pro Arg 
            660                 665                 670         


Gly Leu Pro Gly Glu Pro Gly Pro Arg Gly Leu Leu Gly Pro Lys Gly 
        675                 680                 685             


Pro Pro Gly Pro Pro Gly Pro Pro Gly Val Thr Gly Met Asp Gly Gln 
    690                 695                 700                 


Pro Gly Pro Lys Gly Asn Val Gly Pro Gln Gly Glu Pro Gly Pro Pro 
705                 710                 715                 720 


Gly Gln Gln Gly Asn Pro Gly Ala Gln Gly Leu Pro Gly Pro Gln Gly 
                725                 730                 735     


Ala Ile Gly Pro Pro Gly Glu Lys Gly Pro Leu Gly Lys Pro Gly Leu 
            740                 745                 750         


Pro Gly Met Pro Gly Ala Asp Gly Pro Pro Gly His Pro Gly Lys Glu 
        755                 760                 765             


Gly Pro Pro Gly Glu Lys Gly Gly Gln Gly Pro Pro Gly Pro Gln Gly 
    770                 775                 780                 


Pro Ile Gly Tyr Pro Gly Pro Arg Gly Val Lys Gly Ala Asp Gly Ile 
785                 790                 795                 800 


Arg Gly Leu Lys Gly Thr Lys Gly Glu Lys Gly Glu Asp Gly Phe Pro 
                805                 810                 815     


Gly Phe Lys Gly Asp Met Gly Ile Lys Gly Asp Arg Gly Glu Ile Gly 
            820                 825                 830         


Pro Pro Gly Pro Arg Gly Glu Asp Gly Pro Glu Gly Pro Lys Gly Arg 
        835                 840                 845             


Gly Gly Pro Asn Gly Asp Pro Gly Pro Leu Gly Pro Pro Gly Glu Lys 
    850                 855                 860                 


Gly Lys Leu Gly Val Pro Gly Leu Pro Gly Tyr Pro Gly Arg Gln Gly 
865                 870                 875                 880 


Pro Lys Gly Ser Ile Gly Phe Pro Gly Phe Pro Gly Ala Asn Gly Glu 
                885                 890                 895     


Lys Gly Gly Arg Gly Thr Pro Gly Lys Pro Gly Pro Arg Gly Gln Arg 
            900                 905                 910         


Gly Pro Thr Gly Pro Arg Gly Glu Arg Gly Pro Arg Gly Ile Thr Gly 
        915                 920                 925             


Lys Pro Gly Pro Lys Gly Asn Ser Gly Gly Asp Gly Pro Ala Gly Pro 
    930                 935                 940                 


Pro Gly Glu Arg Gly Pro Asn Gly Pro Gln Gly Pro Thr Gly Phe Pro 
945                 950                 955                 960 


Gly Pro Lys Gly Pro Pro Gly Pro Pro Gly Lys Asp Gly Leu Pro Gly 
                965                 970                 975     


His Pro Gly Gln Arg Gly Glu Thr Gly Phe Gln Gly Lys Thr Gly Pro 
            980                 985                 990         


Pro Gly Pro Pro Gly Val Val Gly  Pro Gln Gly Pro Thr  Gly Glu Thr 
        995                 1000                 1005             


Gly Pro  Met Gly Glu Arg Gly  His Pro Gly Pro Pro  Gly Pro Pro 
    1010                 1015                 1020             


Gly Glu  Gln Gly Leu Pro Gly  Leu Ala Gly Lys Glu  Gly Thr Lys 
    1025                 1030                 1035             


Gly Asp  Pro Gly Pro Ala Gly  Leu Pro Gly Lys Asp  Gly Pro Pro 
    1040                 1045                 1050             


Gly Leu  Arg Gly Phe Pro Gly  Asp Arg Gly Leu Pro  Gly Pro Val 
    1055                 1060                 1065             


Gly Ala  Leu Gly Leu Lys Gly  Asn Glu Gly Pro Pro  Gly Pro Pro 
    1070                 1075                 1080             


Gly Pro  Ala Gly Ser Pro Gly  Glu Arg Gly Pro Ala  Gly Ala Ala 
    1085                 1090                 1095             


Gly Pro  Ile Gly Ile Pro Gly  Arg Pro Gly Pro Gln  Gly Pro Pro 
    1100                 1105                 1110             


Gly Pro  Ala Gly Glu Lys Gly  Ala Pro Gly Glu Lys  Gly Pro Gln 
    1115                 1120                 1125             


Gly Pro  Ala Gly Arg Asp Gly  Leu Gln Gly Pro Val  Gly Leu Pro 
    1130                 1135                 1140             


Gly Pro  Ala Gly Pro Val Gly  Pro Pro Gly Glu Asp  Gly Asp Lys 
    1145                 1150                 1155             


Gly Glu  Ile Gly Glu Pro Gly  Gln Lys Gly Ser Lys  Gly Asp Lys 
    1160                 1165                 1170             


Gly Glu  Gln Gly Pro Pro Gly  Pro Thr Gly Pro Gln  Gly Pro Ile 
    1175                 1180                 1185             


Gly Gln  Pro Gly Pro Ser Gly  Ala Asp Gly Glu Pro  Gly Pro Arg 
    1190                 1195                 1200             


Gly Gln  Gln Gly Leu Phe Gly  Gln Lys Gly Asp Glu  Gly Pro Arg 
    1205                 1210                 1215             


Gly Phe  Pro Gly Pro Pro Gly  Pro Val Gly Leu Gln  Gly Leu Pro 
    1220                 1225                 1230             


Gly Pro  Pro Gly Glu Lys Gly  Glu Thr Gly Asp Val  Gly Gln Met 
    1235                 1240                 1245             


Gly Pro  Pro Gly Pro Pro Gly  Pro Arg Gly Pro Ser  Gly Ala Pro 
    1250                 1255                 1260             


Gly Ala  Asp Gly Pro Gln Gly  Pro Pro Gly Gly Ile  Gly Asn Pro 
    1265                 1270                 1275             


Gly Ala  Val Gly Glu Lys Gly  Glu Pro Gly Glu Ala  Gly Glu Pro 
    1280                 1285                 1290             


Gly Leu  Pro Gly Glu Gly Gly  Pro Pro Gly Pro Lys  Gly Glu Arg 
    1295                 1300                 1305             


Gly Glu  Lys Gly Glu Ser Gly  Pro Ser Gly Ala Ala  Gly Pro Pro 
    1310                 1315                 1320             


Gly Pro  Lys Gly Pro Pro Gly  Asp Asp Gly Pro Lys  Gly Ser Pro 
    1325                 1330                 1335             


Gly Pro  Val Gly Phe Pro Gly  Asp Pro Gly Pro Pro  Gly Glu Pro 
    1340                 1345                 1350             


Gly Pro  Ala Gly Gln Asp Gly  Pro Pro Gly Asp Lys  Gly Asp Asp 
    1355                 1360                 1365             


Gly Glu  Pro Gly Gln Thr Gly  Ser Pro Gly Pro Thr  Gly Glu Pro 
    1370                 1375                 1380             


Gly Pro  Ser Gly Pro Pro Gly  Lys Arg Gly Pro Pro  Gly Pro Ala 
    1385                 1390                 1395             


Gly Pro  Glu Gly Arg Gln Gly  Glu Lys Gly Ala Lys  Gly Glu Ala 
    1400                 1405                 1410             


Gly Leu  Glu Gly Pro Pro Gly  Lys Thr Gly Pro Ile  Gly Pro Gln 
    1415                 1420                 1425             


Gly Ala  Pro Gly Lys Pro Gly  Pro Asp Gly Leu Arg  Gly Ile Pro 
    1430                 1435                 1440             


Gly Pro  Val Gly Glu Gln Gly  Leu Pro Gly Ser Pro  Gly Pro Asp 
    1445                 1450                 1455             


Gly Pro  Pro Gly Pro Met Gly  Pro Pro Gly Leu Pro  Gly Leu Lys 
    1460                 1465                 1470             


Gly Asp  Ser Gly Pro Lys Gly  Glu Lys Gly His Pro  Gly Leu Ile 
    1475                 1480                 1485             


Gly Leu  Ile Gly Pro Pro Gly  Glu Gln Gly Glu Lys  Gly Asp Arg 
    1490                 1495                 1500             


Gly Leu  Pro Gly Pro Gln Gly  Ser Ser Gly Pro Lys  Gly Glu Gln 
    1505                 1510                 1515             


Gly Ile  Thr Gly Pro Ser Gly  Pro Ile Gly Pro Pro  Gly Pro Pro 
    1520                 1525                 1530             


Gly Leu  Pro Gly Pro Pro Gly  Pro Lys Gly Ala Lys  Gly Ser Ser 
    1535                 1540                 1545             


Gly Pro  Thr Gly Pro Lys Gly  Glu Ala Gly His Pro  Gly Pro Pro 
    1550                 1555                 1560             


Gly Pro  Pro Gly Pro Pro Gly  Glu Val Ile Gln Pro  Leu Pro Ile 
    1565                 1570                 1575             


Gln Ala  Ser Arg Thr Arg Arg  Asn Ile Asp Ala Ser  Gln Leu Leu 
    1580                 1585                 1590             


Asp Asp  Gly Asn Gly Glu Asn  Tyr Val Asp Tyr Ala  Asp Gly Met 
    1595                 1600                 1605             


Glu Glu  Ile Phe Gly Ser Leu  Asn Ser Leu Lys Leu  Glu Ile Glu 
    1610                 1615                 1620             


Gln Met  Lys Arg Pro Leu Gly  Thr Gln Gln Asn Pro  Ala Arg Thr 
    1625                 1630                 1635             


Cys Lys  Asp Leu Gln Leu Cys  His Pro Asp Phe Pro  Asp Gly Glu 
    1640                 1645                 1650             


Tyr Trp  Val Asp Pro Asn Gln  Gly Cys Ser Arg Asp  Ser Phe Lys 
    1655                 1660                 1665             


Val Tyr  Cys Asn Phe Thr Ala  Gly Gly Ser Thr Cys  Val Phe Pro 
    1670                 1675                 1680             


Asp Lys  Lys Ser Glu Gly Ser  Lys Met Ala Arg Trp  Pro Lys Glu 
    1685                 1690                 1695             


Gln Pro  Ser Thr Trp Tyr Ser  Gln Tyr Lys Arg Gly  Ser Leu Leu 
    1700                 1705                 1710             


Ser Tyr  Val Asp Ala Glu Gly  Asn Pro Val Gly Val  Val Gln Met 
    1715                 1720                 1725             


Thr Phe  Leu Arg Leu Leu Ser  Ala Ser Ala His Gln  Asn Val Thr 
    1730                 1735                 1740             


Tyr His  Cys Tyr Gln Ser Val  Ala Trp Gln Asp Ala  Ala Thr Gly 
    1745                 1750                 1755             


Ser Tyr  Asp Lys Ala Leu Arg  Phe Leu Gly Ser Asn  Asp Glu Glu 
    1760                 1765                 1770             


Met Ser  Tyr Asp Asn Asn Pro  Tyr Ile Arg Ala Leu  Val Asp Gly 
    1775                 1780                 1785             


Cys Ala  Thr Lys Lys Gly Tyr  Gln Lys Thr Val Leu  Glu Ile Asp 
    1790                 1795                 1800             


Thr Pro  Lys Val Glu Gln Val  Pro Ile Val Asp Ile  Met Phe Asn 
    1805                 1810                 1815             


Asp Phe  Gly Glu Ala Ser Gln  Lys Phe Gly Phe Glu  Val Gly Pro 
    1820                 1825                 1830             


Ala Cys  Phe Met Gly 
    1835             


<210>  3317
<211>  210
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3317

Xaa Arg Thr Arg Arg Asn Ile Asp Ala Ser Gln Leu Leu Asp Asp Gly 
1               5                   10                  15      


Asn Gly Glu Asn Tyr Val Asp Tyr Ala Asp Gly Met Glu Glu Ile Phe 
            20                  25                  30          


Gly Ser Leu Asn Ser Leu Lys Leu Glu Ile Glu Gln Met Lys Arg Pro 
        35                  40                  45              


Leu Gly Thr Gln Gln Asn Pro Ala Arg Thr Cys Lys Asp Leu Gln Leu 
    50                  55                  60                  


Cys His Pro Asp Phe Pro Asp Gly Glu Tyr Trp Val Asp Pro Asn Gln 
65                  70                  75                  80  


Gly Cys Ser Arg Asp Ser Phe Lys Val Tyr Cys Asn Phe Thr Ala Gly 
                85                  90                  95      


Gly Ser Thr Cys Val Phe Pro Asp Lys Lys Ser Glu Gly Ser Lys Met 
            100                 105                 110         


Ala Arg Trp Pro Lys Glu Gln Pro Ser Thr Trp Tyr Ser Gln Tyr Lys 
        115                 120                 125             


Arg Gly Ser Leu Leu Ser Tyr Val Asp Ala Glu Gly Asn Pro Val Gly 
    130                 135                 140                 


Val Val Gln Met Thr Phe Leu Arg Leu Leu Ser Ala Ser Ala His Gln 
145                 150                 155                 160 


Asn Val Thr Tyr His Cys Tyr Gln Ser Val Ala Trp Gln Asp Ala Ala 
                165                 170                 175     


Thr Gly Ser Tyr Asp Lys Ala Leu Arg Phe Leu Gly Ser Asn Asp Glu 
            180                 185                 190         


Glu Met Ser Tyr Asp Asn Asn Pro Tyr Ile Arg Ala Leu Val Asp Gly 
        195                 200                 205             


Cys Ala 
    210 


<210>  3318
<211>  1499
<212>  PRT
<213>  Homo Sapiens

<400>  3318

Met Met Ala Asn Trp Ala Glu Ala Arg Pro Leu Leu Ile Leu Ile Val 
1               5                   10                  15      


Leu Leu Gly Gln Phe Val Ser Ile Lys Ala Gln Glu Glu Asp Glu Asp 
            20                  25                  30          


Glu Gly Tyr Gly Glu Glu Ile Ala Cys Thr Gln Asn Gly Gln Met Tyr 
        35                  40                  45              


Leu Asn Arg Asp Ile Trp Lys Pro Ala Pro Cys Gln Ile Cys Val Cys 
    50                  55                  60                  


Asp Asn Gly Ala Ile Leu Cys Asp Lys Ile Glu Cys Gln Asp Val Leu 
65                  70                  75                  80  


Asp Cys Ala Asp Pro Val Thr Pro Pro Gly Glu Cys Cys Pro Val Cys 
                85                  90                  95      


Ser Gln Thr Pro Gly Gly Gly Asn Thr Asn Phe Gly Arg Gly Arg Lys 
            100                 105                 110         


Gly Gln Lys Gly Glu Pro Gly Leu Val Pro Val Val Thr Gly Ile Arg 
        115                 120                 125             


Gly Arg Pro Gly Pro Ala Gly Pro Pro Gly Ser Gln Gly Pro Arg Gly 
    130                 135                 140                 


Glu Arg Gly Pro Lys Gly Arg Pro Gly Pro Arg Gly Pro Gln Gly Ile 
145                 150                 155                 160 


Asp Gly Glu Pro Gly Val Pro Gly Gln Pro Gly Ala Pro Gly Pro Pro 
                165                 170                 175     


Gly His Pro Ser His Pro Gly Pro Asp Gly Leu Ser Arg Pro Phe Ser 
            180                 185                 190         


Ala Gln Met Ala Gly Leu Asp Glu Lys Ser Gly Leu Gly Ser Gln Val 
        195                 200                 205             


Gly Leu Met Pro Gly Ser Val Gly Pro Val Gly Pro Arg Gly Pro Gln 
    210                 215                 220                 


Gly Leu Gln Gly Gln Gln Gly Gly Ala Gly Pro Thr Gly Pro Pro Gly 
225                 230                 235                 240 


Glu Pro Gly Asp Pro Gly Pro Met Gly Pro Ile Gly Ser Arg Gly Pro 
                245                 250                 255     


Glu Gly Pro Pro Gly Lys Pro Gly Glu Asp Gly Glu Pro Gly Arg Asn 
            260                 265                 270         


Gly Asn Pro Gly Glu Val Gly Phe Ala Gly Ser Pro Gly Ala Arg Gly 
        275                 280                 285             


Phe Pro Gly Ala Pro Gly Leu Pro Gly Leu Lys Gly His Arg Gly His 
    290                 295                 300                 


Lys Gly Leu Glu Gly Pro Lys Gly Glu Val Gly Ala Pro Gly Ser Lys 
305                 310                 315                 320 


Gly Glu Ala Gly Pro Thr Gly Pro Met Gly Ala Met Gly Pro Leu Gly 
                325                 330                 335     


Pro Arg Gly Met Pro Gly Glu Arg Gly Arg Leu Gly Pro Gln Gly Ala 
            340                 345                 350         


Pro Gly Gln Arg Gly Ala His Gly Met Pro Gly Lys Pro Gly Pro Met 
        355                 360                 365             


Gly Pro Leu Gly Ile Pro Gly Ser Ser Gly Phe Pro Gly Asn Pro Gly 
    370                 375                 380                 


Met Lys Gly Glu Ala Gly Pro Thr Gly Ala Arg Gly Pro Glu Gly Pro 
385                 390                 395                 400 


Gln Gly Gln Arg Gly Glu Thr Gly Pro Pro Gly Pro Val Gly Ser Pro 
                405                 410                 415     


Gly Leu Pro Gly Ala Ile Gly Thr Asp Gly Thr Pro Gly Ala Lys Gly 
            420                 425                 430         


Pro Thr Gly Ser Pro Gly Thr Ser Gly Pro Pro Gly Ser Ala Gly Pro 
        435                 440                 445             


Pro Gly Ser Pro Gly Pro Gln Gly Ser Thr Gly Pro Gln Gly Ile Arg 
    450                 455                 460                 


Gly Gln Pro Gly Asp Pro Gly Val Pro Gly Phe Lys Gly Glu Ala Gly 
465                 470                 475                 480 


Pro Lys Gly Glu Pro Gly Pro His Gly Ile Gln Gly Pro Ile Gly Pro 
                485                 490                 495     


Pro Gly Glu Glu Gly Lys Arg Gly Pro Arg Gly Asp Pro Gly Thr Val 
            500                 505                 510         


Gly Pro Pro Gly Pro Val Gly Glu Arg Gly Ala Pro Gly Asn Arg Gly 
        515                 520                 525             


Phe Pro Gly Ser Asp Gly Leu Pro Gly Pro Lys Gly Ala Gln Gly Glu 
    530                 535                 540                 


Arg Gly Pro Val Gly Ser Ser Gly Pro Lys Gly Ser Gln Gly Asp Pro 
545                 550                 555                 560 


Gly Arg Pro Gly Glu Pro Gly Leu Pro Gly Ala Arg Gly Leu Thr Gly 
                565                 570                 575     


Asn Pro Gly Val Gln Gly Pro Glu Gly Lys Leu Gly Pro Leu Gly Ala 
            580                 585                 590         


Pro Gly Glu Asp Gly Arg Pro Gly Pro Pro Gly Ser Ile Gly Ile Arg 
        595                 600                 605             


Gly Gln Pro Gly Ser Met Gly Leu Pro Gly Pro Lys Gly Ser Ser Gly 
    610                 615                 620                 


Asp Pro Gly Lys Pro Gly Glu Ala Gly Asn Ala Gly Val Pro Gly Gln 
625                 630                 635                 640 


Arg Gly Ala Pro Gly Lys Asp Gly Glu Val Gly Pro Ser Gly Pro Val 
                645                 650                 655     


Gly Pro Pro Gly Leu Ala Gly Glu Arg Gly Glu Gln Gly Pro Pro Gly 
            660                 665                 670         


Pro Thr Gly Phe Gln Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Glu 
        675                 680                 685             


Gly Gly Lys Pro Gly Asp Gln Gly Val Pro Gly Asp Pro Gly Ala Val 
    690                 695                 700                 


Gly Pro Leu Gly Pro Arg Gly Glu Arg Gly Asn Pro Gly Glu Arg Gly 
705                 710                 715                 720 


Glu Pro Gly Ile Thr Gly Leu Pro Gly Glu Lys Gly Met Ala Gly Gly 
                725                 730                 735     


His Gly Pro Asp Gly Pro Lys Gly Ser Pro Gly Pro Ser Gly Thr Pro 
            740                 745                 750         


Gly Asp Thr Gly Pro Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly 
        755                 760                 765             


Ile Ala Gly Thr Pro Gly Pro Lys Gly Asp Arg Gly Gly Ile Gly Glu 
    770                 775                 780                 


Lys Gly Ala Glu Gly Thr Ala Gly Asn Asp Gly Ala Arg Gly Leu Pro 
785                 790                 795                 800 


Gly Pro Leu Gly Pro Pro Gly Pro Ala Gly Pro Thr Gly Glu Lys Gly 
                805                 810                 815     


Glu Pro Gly Pro Arg Gly Leu Val Gly Pro Pro Gly Ser Arg Gly Asn 
            820                 825                 830         


Pro Gly Ser Arg Gly Glu Asn Gly Pro Thr Gly Ala Val Gly Phe Ala 
        835                 840                 845             


Gly Pro Gln Gly Pro Asp Gly Gln Pro Gly Val Lys Gly Glu Pro Gly 
    850                 855                 860                 


Glu Pro Gly Gln Lys Gly Asp Ala Gly Ser Pro Gly Pro Gln Gly Leu 
865                 870                 875                 880 


Ala Gly Ser Pro Gly Pro His Gly Pro Asn Gly Val Pro Gly Leu Lys 
                885                 890                 895     


Gly Gly Arg Gly Thr Gln Gly Pro Pro Gly Ala Thr Gly Phe Pro Gly 
            900                 905                 910         


Ser Ala Gly Arg Val Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro 
        915                 920                 925             


Ala Gly Pro Leu Gly Glu Pro Gly Lys Glu Gly Pro Pro Gly Leu Arg 
    930                 935                 940                 


Gly Asp Pro Gly Ser His Gly Arg Val Gly Asp Arg Gly Pro Ala Gly 
945                 950                 955                 960 


Pro Pro Gly Gly Pro Gly Asp Lys Gly Asp Pro Gly Glu Asp Gly Gln 
                965                 970                 975     


Pro Gly Pro Asp Gly Pro Pro Gly Pro Ala Gly Thr Thr Gly Gln Arg 
            980                 985                 990         


Gly Ile Val Gly Met Pro Gly Gln  Arg Gly Glu Arg Gly  Met Pro Gly 
        995                 1000                 1005             


Leu Pro  Gly Pro Ala Gly Thr  Pro Gly Lys Val Gly  Pro Thr Gly 
    1010                 1015                 1020             


Ala Thr  Gly Asp Lys Gly Pro  Pro Gly Pro Val Gly  Pro Pro Gly 
    1025                 1030                 1035             


Ser Asn  Gly Pro Val Gly Glu  Pro Gly Pro Glu Gly  Pro Ala Gly 
    1040                 1045                 1050             


Asn Asp  Gly Thr Pro Gly Arg  Asp Gly Ala Val Gly  Glu Arg Gly 
    1055                 1060                 1065             


Asp Arg  Gly Asp Pro Gly Pro  Ala Gly Leu Pro Gly  Ser Gln Gly 
    1070                 1075                 1080             


Ala Pro  Gly Thr Pro Gly Pro  Val Gly Ala Pro Gly  Asp Ala Gly 
    1085                 1090                 1095             


Gln Arg  Gly Asp Pro Gly Ser  Arg Gly Pro Ile Gly  Pro Pro Gly 
    1100                 1105                 1110             


Arg Ala  Gly Lys Arg Gly Leu  Pro Gly Pro Gln Gly  Pro Arg Gly 
    1115                 1120                 1125             


Asp Lys  Gly Asp His Gly Asp  Arg Gly Asp Arg Gly  Gln Lys Gly 
    1130                 1135                 1140             


His Arg  Gly Phe Thr Gly Leu  Gln Gly Leu Pro Gly  Pro Pro Gly 
    1145                 1150                 1155             


Pro Asn  Gly Glu Gln Gly Ser  Ala Gly Ile Pro Gly  Pro Phe Gly 
    1160                 1165                 1170             


Pro Arg  Gly Pro Pro Gly Pro  Val Gly Pro Ser Gly  Lys Glu Gly 
    1175                 1180                 1185             


Asn Pro  Gly Pro Leu Gly Pro  Ile Gly Pro Pro Gly  Val Arg Gly 
    1190                 1195                 1200             


Ser Val  Gly Glu Ala Gly Pro  Glu Gly Pro Pro Gly  Glu Pro Gly 
    1205                 1210                 1215             


Pro Pro  Gly Pro Pro Gly Pro  Pro Gly His Leu Thr  Ala Ala Leu 
    1220                 1225                 1230             


Gly Asp  Ile Met Gly His Tyr  Asp Glu Ser Met Pro  Asp Pro Leu 
    1235                 1240                 1245             


Pro Glu  Phe Thr Glu Asp Gln  Ala Ala Pro Asp Asp  Lys Asn Lys 
    1250                 1255                 1260             


Thr Asp  Pro Gly Val His Ala  Thr Leu Lys Ser Leu  Ser Ser Gln 
    1265                 1270                 1275             


Ile Glu  Thr Met Arg Ser Pro  Asp Gly Ser Lys Lys  His Pro Ala 
    1280                 1285                 1290             


Arg Thr  Cys Asp Asp Leu Lys  Leu Cys His Ser Ala  Lys Gln Ser 
    1295                 1300                 1305             


Gly Glu  Tyr Trp Ile Asp Pro  Asn Gln Gly Ser Val  Glu Asp Ala 
    1310                 1315                 1320             


Ile Lys  Val Tyr Cys Asn Met  Glu Thr Gly Glu Thr  Cys Ile Ser 
    1325                 1330                 1335             


Ala Asn  Pro Ser Ser Val Pro  Arg Lys Thr Trp Trp  Ala Ser Lys 
    1340                 1345                 1350             


Ser Pro  Asp Asn Lys Pro Val  Trp Tyr Gly Leu Asp  Met Asn Arg 
    1355                 1360                 1365             


Gly Ser  Gln Phe Ala Tyr Gly  Asp His Gln Ser Pro  Asn Thr Ala 
    1370                 1375                 1380             


Ile Thr  Gln Met Thr Phe Leu  Arg Leu Leu Ser Lys  Glu Ala Ser 
    1385                 1390                 1395             


Gln Asn  Ile Thr Tyr Ile Cys  Lys Asn Ser Val Gly  Tyr Met Asp 
    1400                 1405                 1410             


Asp Gln  Ala Lys Asn Leu Lys  Lys Ala Val Val Leu  Lys Gly Ala 
    1415                 1420                 1425             


Asn Asp  Leu Asp Ile Lys Ala  Glu Gly Asn Ile Arg  Phe Arg Tyr 
    1430                 1435                 1440             


Ile Val  Leu Gln Asp Thr Cys  Ser Lys Arg Asn Gly  Asn Val Gly 
    1445                 1450                 1455             


Lys Thr  Val Phe Glu Tyr Arg  Thr Gln Asn Val Ala  Arg Leu Pro 
    1460                 1465                 1470             


Ile Ile  Asp Leu Ala Pro Val  Asp Val Gly Gly Thr  Asp Gln Glu 
    1475                 1480                 1485             


Phe Gly  Val Glu Ile Gly Pro  Val Cys Phe Val 
    1490                 1495                 


<210>  3319
<211>  1112
<212>  PRT
<213>  Homo Sapiens

<400>  3319

Met Pro Gly Ser Val Gly Pro Val Gly Pro Arg Gly Pro Gln Gly Leu 
1               5                   10                  15      


Gln Gly Gln Gln Gly Gly Ala Gly Pro Thr Gly Pro Pro Gly Glu Pro 
            20                  25                  30          


Gly Asp Pro Gly Pro Met Gly Pro Ile Gly Ser Arg Gly Pro Glu Gly 
        35                  40                  45              


Pro Pro Gly Lys Pro Gly Glu Asp Gly Glu Pro Gly Arg Asn Gly Asn 
    50                  55                  60                  


Pro Gly Glu Val Gly Phe Ala Gly Ser Pro Gly Ala Arg Gly Phe Pro 
65                  70                  75                  80  


Gly Ala Pro Gly Leu Pro Gly Leu Lys Gly His Arg Gly His Lys Gly 
                85                  90                  95      


Leu Glu Gly Pro Lys Gly Glu Val Gly Ala Pro Gly Ser Lys Gly Glu 
            100                 105                 110         


Ala Gly Pro Thr Gly Pro Met Gly Asp Pro Gly Thr Val Gly Pro Pro 
        115                 120                 125             


Gly Pro Val Gly Glu Arg Gly Ala Pro Gly Asn Arg Gly Phe Pro Gly 
    130                 135                 140                 


Ser Asp Gly Leu Pro Gly Pro Lys Gly Ala Gln Gly Glu Arg Gly Pro 
145                 150                 155                 160 


Val Gly Ser Ser Gly Pro Lys Gly Ser Gln Gly Asp Pro Gly Arg Pro 
                165                 170                 175     


Gly Glu Pro Gly Leu Pro Gly Ala Arg Gly Leu Thr Gly Asn Pro Gly 
            180                 185                 190         


Val Gln Gly Pro Glu Gly Lys Leu Gly Pro Leu Gly Ala Pro Gly Glu 
        195                 200                 205             


Asp Gly Arg Pro Gly Pro Pro Gly Ser Ile Gly Ile Arg Gly Gln Pro 
    210                 215                 220                 


Gly Ser Met Gly Leu Pro Gly Pro Lys Gly Ser Ser Gly Asp Pro Gly 
225                 230                 235                 240 


Lys Pro Gly Glu Ala Gly Asn Ala Gly Val Pro Gly Gln Arg Gly Ala 
                245                 250                 255     


Pro Gly Lys Asp Gly Glu Val Gly Pro Ser Gly Pro Val Gly Pro Pro 
            260                 265                 270         


Gly Leu Ala Gly Glu Arg Gly Glu Gln Gly Pro Pro Gly Pro Thr Gly 
        275                 280                 285             


Phe Gln Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Glu Gly Gly Lys 
    290                 295                 300                 


Pro Gly Asp Gln Gly Val Pro Gly Asp Pro Gly Ala Val Gly Pro Leu 
305                 310                 315                 320 


Gly Pro Arg Gly Glu Arg Gly Asn Pro Gly Glu Arg Gly Glu Pro Gly 
                325                 330                 335     


Ile Thr Gly Leu Pro Gly Glu Lys Gly Met Ala Gly Gly His Gly Pro 
            340                 345                 350         


Asp Gly Pro Lys Gly Ser Pro Gly Pro Ser Gly Thr Pro Gly Asp Thr 
        355                 360                 365             


Gly Pro Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Ile Ala Gly 
    370                 375                 380                 


Thr Pro Gly Pro Lys Gly Asp Arg Gly Gly Ile Gly Glu Lys Gly Ala 
385                 390                 395                 400 


Glu Gly Thr Ala Gly Asn Asp Gly Ala Arg Gly Leu Pro Gly Pro Leu 
                405                 410                 415     


Gly Pro Pro Gly Pro Ala Gly Pro Thr Gly Glu Lys Gly Glu Pro Gly 
            420                 425                 430         


Pro Arg Gly Leu Val Gly Pro Pro Gly Ser Arg Gly Asn Pro Gly Ser 
        435                 440                 445             


Arg Gly Glu Asn Gly Pro Thr Gly Ala Val Gly Phe Ala Gly Pro Gln 
    450                 455                 460                 


Gly Pro Asp Gly Gln Pro Gly Val Lys Gly Glu Pro Gly Glu Pro Gly 
465                 470                 475                 480 


Gln Lys Gly Asp Ala Gly Ser Pro Gly Pro Gln Gly Leu Ala Gly Ser 
                485                 490                 495     


Pro Gly Pro His Gly Pro Asn Gly Val Pro Gly Leu Lys Gly Gly Arg 
            500                 505                 510         


Gly Thr Gln Gly Pro Pro Gly Ala Thr Gly Phe Pro Gly Ser Ala Gly 
        515                 520                 525             


Arg Val Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro Ala Gly Pro 
    530                 535                 540                 


Leu Gly Glu Pro Gly Lys Glu Gly Pro Pro Gly Leu Arg Gly Asp Pro 
545                 550                 555                 560 


Gly Ser His Gly Arg Val Gly Asp Arg Gly Pro Ala Gly Pro Pro Gly 
                565                 570                 575     


Gly Pro Gly Asp Lys Gly Asp Pro Gly Glu Asp Gly Gln Pro Gly Pro 
            580                 585                 590         


Asp Gly Pro Pro Gly Pro Ala Gly Thr Thr Gly Gln Arg Gly Ile Val 
        595                 600                 605             


Gly Met Pro Gly Gln Arg Gly Glu Arg Gly Met Pro Gly Leu Pro Gly 
    610                 615                 620                 


Pro Ala Gly Thr Pro Gly Lys Val Gly Pro Thr Gly Ala Thr Gly Asp 
625                 630                 635                 640 


Lys Gly Pro Pro Gly Pro Val Gly Pro Pro Gly Ser Asn Gly Pro Val 
                645                 650                 655     


Gly Glu Pro Gly Pro Glu Gly Pro Ala Gly Asn Asp Gly Thr Pro Gly 
            660                 665                 670         


Arg Asp Gly Ala Val Gly Glu Arg Gly Asp Arg Gly Asp Pro Gly Pro 
        675                 680                 685             


Ala Gly Leu Pro Gly Ser Gln Gly Ala Pro Gly Thr Pro Gly Pro Val 
    690                 695                 700                 


Gly Ala Pro Gly Asp Ala Gly Gln Arg Gly Asp Pro Gly Ser Arg Gly 
705                 710                 715                 720 


Pro Ile Gly Pro Pro Gly Arg Ala Gly Lys Arg Gly Leu Pro Gly Pro 
                725                 730                 735     


Gln Gly Pro Arg Gly Asp Lys Gly Asp His Gly Asp Arg Gly Asp Arg 
            740                 745                 750         


Gly Gln Lys Gly His Arg Gly Phe Thr Gly Leu Gln Gly Leu Pro Gly 
        755                 760                 765             


Pro Pro Gly Pro Asn Gly Glu Gln Gly Ser Ala Gly Ile Pro Gly Pro 
    770                 775                 780                 


Phe Gly Pro Arg Gly Pro Pro Gly Pro Val Gly Pro Ser Gly Lys Glu 
785                 790                 795                 800 


Gly Asn Pro Gly Pro Leu Gly Pro Ile Gly Pro Pro Gly Val Arg Gly 
                805                 810                 815     


Ser Val Gly Glu Ala Gly Pro Glu Gly Pro Pro Gly Glu Pro Gly Pro 
            820                 825                 830         


Pro Gly Pro Pro Gly Pro Pro Gly His Leu Thr Ala Ala Leu Gly Asp 
        835                 840                 845             


Ile Met Gly His Tyr Asp Glu Ser Met Pro Asp Pro Leu Pro Glu Phe 
    850                 855                 860                 


Thr Glu Asp Gln Ala Ala Pro Asp Asp Lys Asn Lys Thr Asp Pro Gly 
865                 870                 875                 880 


Val His Ala Thr Leu Lys Ser Leu Ser Ser Gln Ile Glu Thr Met Arg 
                885                 890                 895     


Ser Pro Asp Gly Ser Lys Lys His Pro Ala Arg Thr Cys Asp Asp Leu 
            900                 905                 910         


Lys Leu Cys His Ser Ala Lys Gln Ser Gly Glu Tyr Trp Ile Asp Pro 
        915                 920                 925             


Asn Gln Gly Ser Val Glu Asp Ala Ile Lys Val Tyr Cys Asn Met Glu 
    930                 935                 940                 


Thr Gly Glu Thr Cys Ile Ser Ala Asn Pro Ser Ser Val Pro Arg Lys 
945                 950                 955                 960 


Thr Trp Trp Ala Ser Lys Ser Pro Asp Asn Lys Pro Val Trp Tyr Gly 
                965                 970                 975     


Leu Asp Met Asn Arg Gly Ser Gln Phe Ala Tyr Gly Asp His Gln Ser 
            980                 985                 990         


Pro Asn Thr Ala Ile Thr Gln Met  Thr Phe Leu Arg Leu  Leu Ser Lys 
        995                 1000                 1005             


Glu Ala  Ser Gln Asn Ile Thr  Tyr Ile Cys Lys Asn  Ser Val Gly 
    1010                 1015                 1020             


Tyr Met  Asp Asp Gln Ala Lys  Asn Leu Lys Lys Ala  Val Val Leu 
    1025                 1030                 1035             


Lys Gly  Ala Asn Asp Leu Asp  Ile Lys Ala Glu Gly  Asn Ile Arg 
    1040                 1045                 1050             


Phe Arg  Tyr Ile Val Leu Gln  Asp Thr Cys Ser Lys  Arg Asn Gly 
    1055                 1060                 1065             


Asn Val  Gly Lys Thr Val Phe  Glu Tyr Arg Thr Gln  Asn Val Ala 
    1070                 1075                 1080             


Arg Leu  Pro Ile Ile Asp Leu  Ala Pro Val Asp Val  Gly Gly Thr 
    1085                 1090                 1095             


Asp Gln  Glu Phe Gly Val Glu  Ile Gly Pro Val Cys  Phe Val 
    1100                 1105                 1110         


<210>  3320
<211>  1745
<212>  PRT
<213>  Homo Sapiens

<400>  3320

Met Gly Asn Arg Arg Asp Leu Gly Gln Pro Arg Ala Gly Leu Cys Leu 
1               5                   10                  15      


Leu Leu Ala Ala Leu Gln Leu Leu Pro Gly Thr Gln Ala Asp Pro Val 
            20                  25                  30          


Asp Val Leu Lys Ala Leu Gly Val Gln Gly Gly Gln Ala Gly Val Pro 
        35                  40                  45              


Glu Gly Pro Gly Phe Cys Pro Gln Arg Thr Pro Glu Gly Asp Arg Ala 
    50                  55                  60                  


Phe Arg Ile Gly Gln Ala Ser Thr Leu Gly Ile Pro Thr Trp Glu Leu 
65                  70                  75                  80  


Phe Pro Glu Gly His Phe Pro Glu Asn Phe Ser Leu Leu Ile Thr Leu 
                85                  90                  95      


Arg Gly Gln Pro Ala Asn Gln Ser Val Leu Leu Ser Ile Tyr Asp Glu 
            100                 105                 110         


Arg Gly Ala Arg Gln Leu Gly Leu Ala Leu Gly Pro Ala Leu Gly Leu 
        115                 120                 125             


Leu Gly Asp Pro Phe Arg Pro Leu Pro Gln Gln Val Asn Leu Thr Asp 
    130                 135                 140                 


Gly Arg Trp His Arg Val Ala Val Ser Ile Asp Gly Glu Met Val Thr 
145                 150                 155                 160 


Leu Val Ala Asp Cys Glu Ala Gln Pro Pro Val Leu Gly His Gly Pro 
                165                 170                 175     


Arg Phe Ile Ser Ile Ala Gly Leu Thr Val Leu Gly Thr Gln Asp Leu 
            180                 185                 190         


Gly Glu Lys Thr Phe Glu Gly Asp Ile Gln Glu Leu Leu Ile Ser Pro 
        195                 200                 205             


Asp Pro Gln Ala Ala Phe Gln Ala Cys Glu Arg Tyr Leu Pro Asp Cys 
    210                 215                 220                 


Asp Asn Leu Ala Pro Ala Ala Thr Val Ala Pro Gln Gly Glu Pro Glu 
225                 230                 235                 240 


Thr Pro Arg Pro Arg Arg Lys Gly Lys Gly Lys Gly Arg Lys Lys Gly 
                245                 250                 255     


Arg Gly Arg Lys Gly Lys Gly Arg Lys Lys Asn Lys Glu Ile Trp Thr 
            260                 265                 270         


Ser Ser Pro Pro Pro Asp Ser Ala Glu Asn Gln Thr Ser Thr Asp Ile 
        275                 280                 285             


Pro Lys Thr Glu Thr Pro Ala Pro Asn Leu Pro Pro Thr Pro Thr Pro 
    290                 295                 300                 


Leu Val Val Thr Ser Thr Val Thr Thr Gly Leu Asn Ala Thr Ile Leu 
305                 310                 315                 320 


Glu Arg Ser Leu Asp Pro Asp Ser Gly Thr Glu Leu Gly Thr Leu Glu 
                325                 330                 335     


Thr Lys Ala Ala Arg Glu Asp Glu Glu Gly Asp Asp Ser Thr Met Gly 
            340                 345                 350         


Pro Asp Phe Arg Ala Ala Glu Tyr Pro Ser Arg Thr Gln Phe Gln Ile 
        355                 360                 365             


Phe Pro Gly Ala Gly Glu Lys Gly Ala Lys Gly Glu Pro Ala Val Ile 
    370                 375                 380                 


Glu Lys Gly Gln Gln Phe Glu Gly Pro Pro Gly Ala Pro Gly Pro Gln 
385                 390                 395                 400 


Gly Val Val Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly Phe Pro Gly 
                405                 410                 415     


Asp Pro Gly Pro Pro Gly Pro Ala Gly Leu Pro Gly Ile Pro Gly Ile 
            420                 425                 430         


Asp Gly Ile Arg Gly Pro Pro Gly Thr Val Ile Met Met Pro Phe Gln 
        435                 440                 445             


Phe Ala Gly Gly Ser Phe Lys Gly Pro Pro Val Ser Phe Gln Gln Ala 
    450                 455                 460                 


Gln Ala Gln Ala Val Leu Gln Gln Thr Gln Leu Ser Met Lys Gly Pro 
465                 470                 475                 480 


Pro Gly Pro Val Gly Leu Thr Gly Arg Pro Gly Pro Val Gly Leu Pro 
                485                 490                 495     


Gly His Pro Gly Leu Lys Gly Glu Glu Gly Ala Glu Gly Pro Gln Gly 
            500                 505                 510         


Pro Arg Gly Leu Gln Gly Pro His Gly Pro Pro Gly Arg Val Gly Lys 
        515                 520                 525             


Met Gly Arg Pro Gly Ala Asp Gly Ala Arg Gly Leu Pro Gly Asp Thr 
    530                 535                 540                 


Gly Pro Lys Gly Asp Arg Gly Phe Asp Gly Leu Pro Gly Leu Pro Gly 
545                 550                 555                 560 


Glu Lys Gly Gln Arg Gly Asp Phe Gly His Val Gly Gln Pro Gly Pro 
                565                 570                 575     


Pro Gly Glu Asp Gly Glu Arg Gly Ala Glu Gly Pro Pro Gly Pro Thr 
            580                 585                 590         


Gly Gln Ala Gly Glu Pro Gly Pro Arg Gly Leu Leu Gly Pro Arg Gly 
        595                 600                 605             


Ser Pro Gly Pro Thr Gly Arg Pro Gly Val Thr Gly Ile Asp Gly Ala 
    610                 615                 620                 


Pro Gly Ala Lys Gly Asn Val Gly Pro Pro Gly Glu Pro Gly Pro Pro 
625                 630                 635                 640 


Gly Gln Gln Gly Asn His Gly Ser Gln Gly Leu Pro Gly Pro Gln Gly 
                645                 650                 655     


Leu Ile Gly Thr Pro Gly Glu Lys Gly Pro Pro Gly Asn Pro Gly Ile 
            660                 665                 670         


Pro Gly Leu Pro Gly Ser Asp Gly Pro Leu Gly His Pro Gly His Glu 
        675                 680                 685             


Gly Pro Thr Gly Glu Lys Gly Ala Gln Gly Pro Pro Gly Ser Ala Gly 
    690                 695                 700                 


Pro Pro Gly Tyr Pro Gly Pro Arg Gly Val Lys Gly Thr Ser Gly Asn 
705                 710                 715                 720 


Arg Gly Leu Gln Gly Glu Lys Gly Glu Lys Gly Glu Asp Gly Phe Pro 
                725                 730                 735     


Gly Phe Lys Gly Asp Val Gly Leu Lys Gly Asp Gln Gly Lys Pro Gly 
            740                 745                 750         


Ala Pro Gly Pro Arg Gly Glu Asp Gly Pro Glu Gly Pro Lys Gly Gln 
        755                 760                 765             


Ala Gly Gln Ala Gly Glu Glu Gly Pro Pro Gly Ser Ala Gly Glu Lys 
    770                 775                 780                 


Gly Lys Leu Gly Val Pro Gly Leu Pro Gly Tyr Pro Gly Arg Pro Gly 
785                 790                 795                 800 


Pro Lys Gly Ser Ile Gly Phe Pro Gly Pro Leu Gly Pro Ile Gly Glu 
                805                 810                 815     


Lys Gly Lys Ser Gly Lys Thr Gly Gln Pro Gly Leu Glu Gly Glu Arg 
            820                 825                 830         


Gly Pro Pro Gly Ser Arg Gly Glu Arg Gly Gln Pro Gly Ala Thr Gly 
        835                 840                 845             


Gln Pro Gly Pro Lys Gly Asp Val Gly Gln Asp Gly Ala Pro Gly Ile 
    850                 855                 860                 


Pro Gly Glu Lys Gly Leu Pro Gly Leu Gln Gly Pro Pro Gly Phe Pro 
865                 870                 875                 880 


Gly Pro Lys Gly Pro Pro Gly His Gln Gly Lys Asp Gly Arg Pro Gly 
                885                 890                 895     


His Pro Gly Gln Arg Gly Glu Leu Gly Phe Gln Gly Gln Thr Gly Pro 
            900                 905                 910         


Pro Gly Pro Ala Gly Val Leu Gly Pro Gln Gly Lys Thr Gly Glu Val 
        915                 920                 925             


Gly Pro Leu Gly Glu Arg Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
    930                 935                 940                 


Glu Gln Gly Leu Pro Gly Leu Glu Gly Arg Glu Gly Ala Lys Gly Glu 
945                 950                 955                 960 


Leu Gly Pro Pro Gly Pro Leu Gly Lys Glu Gly Pro Ala Gly Leu Arg 
                965                 970                 975     


Gly Phe Pro Gly Pro Lys Gly Gly Pro Gly Asp Pro Gly Pro Thr Gly 
            980                 985                 990         


Leu Lys Gly Asp Lys Gly Pro Pro  Gly Pro Val Gly Ala  Asn Gly Ser 
        995                 1000                 1005             


Pro Gly  Glu Arg Gly Pro Leu  Gly Pro Ala Gly Gly  Ile Gly Leu 
    1010                 1015                 1020             


Pro Gly  Gln Ser Gly Ser Glu  Gly Pro Val Gly Pro  Ala Gly Lys 
    1025                 1030                 1035             


Lys Gly  Ser Arg Gly Glu Arg  Gly Pro Pro Gly Pro  Thr Gly Lys 
    1040                 1045                 1050             


Asp Gly  Ile Pro Gly Pro Leu  Gly Pro Leu Gly Pro  Pro Gly Ala 
    1055                 1060                 1065             


Ala Gly  Pro Ser Gly Glu Glu  Gly Asp Lys Gly Asp  Val Gly Ala 
    1070                 1075                 1080             


Pro Gly  His Lys Gly Ser Lys  Gly Asp Lys Gly Asp  Ala Gly Pro 
    1085                 1090                 1095             


Pro Gly  Gln Pro Gly Ile Arg  Gly Pro Ala Gly His  Pro Gly Pro 
    1100                 1105                 1110             


Pro Gly  Ala Asp Gly Ala Gln  Gly Arg Arg Gly Pro  Pro Gly Leu 
    1115                 1120                 1125             


Phe Gly  Gln Lys Gly Asp Asp  Gly Val Arg Gly Phe  Val Gly Val 
    1130                 1135                 1140             


Ile Gly  Pro Pro Gly Leu Gln  Gly Leu Pro Gly Pro  Pro Gly Glu 
    1145                 1150                 1155             


Lys Gly  Glu Val Gly Asp Val  Gly Ser Met Gly Pro  His Gly Ala 
    1160                 1165                 1170             


Pro Gly  Pro Arg Gly Pro Gln  Gly Pro Thr Gly Ser  Glu Gly Thr 
    1175                 1180                 1185             


Pro Gly  Leu Pro Gly Gly Val  Gly Gln Pro Gly Ala  Val Gly Glu 
    1190                 1195                 1200             


Lys Gly  Glu Arg Gly Asp Ala  Gly Asp Pro Gly Pro  Pro Gly Ala 
    1205                 1210                 1215             


Pro Gly  Ile Pro Gly Pro Lys  Gly Asp Ile Gly Glu  Lys Gly Asp 
    1220                 1225                 1230             


Ser Gly  Pro Ser Gly Ala Ala  Gly Pro Pro Gly Lys  Lys Gly Pro 
    1235                 1240                 1245             


Pro Gly  Glu Asp Gly Ala Lys  Gly Ser Val Gly Pro  Thr Gly Leu 
    1250                 1255                 1260             


Pro Gly  Asp Leu Gly Pro Pro  Gly Asp Pro Gly Val  Ser Gly Ile 
    1265                 1270                 1275             


Asp Gly  Ser Pro Gly Glu Lys  Gly Asp Pro Gly Asp  Val Gly Gly 
    1280                 1285                 1290             


Pro Gly  Pro Pro Gly Ala Ser  Gly Glu Pro Gly Ala  Pro Gly Pro 
    1295                 1300                 1305             


Pro Gly  Lys Arg Gly Pro Ser  Gly His Met Gly Arg  Glu Gly Arg 
    1310                 1315                 1320             


Glu Gly  Glu Lys Gly Ala Lys  Gly Glu Pro Gly Pro  Asp Gly Pro 
    1325                 1330                 1335             


Pro Gly  Arg Thr Gly Pro Met  Gly Ala Arg Gly Pro  Pro Gly Arg 
    1340                 1345                 1350             


Val Gly  Pro Glu Gly Leu Arg  Gly Ile Pro Gly Pro  Val Gly Glu 
    1355                 1360                 1365             


Pro Gly  Leu Leu Gly Ala Pro  Gly Gln Met Gly Pro  Pro Gly Pro 
    1370                 1375                 1380             


Leu Gly  Pro Ser Gly Leu Pro  Gly Leu Lys Gly Asp  Thr Gly Pro 
    1385                 1390                 1395             


Lys Gly  Glu Lys Gly His Ile  Gly Leu Ile Gly Leu  Ile Gly Pro 
    1400                 1405                 1410             


Pro Gly  Glu Ala Gly Glu Lys  Gly Asp Gln Gly Leu  Pro Gly Val 
    1415                 1420                 1425             


Gln Gly  Pro Pro Gly Pro Lys  Gly Asp Pro Gly Pro  Pro Gly Pro 
    1430                 1435                 1440             


Ile Gly  Ser Leu Gly His Pro  Gly Pro Pro Gly Val  Ala Gly Pro 
    1445                 1450                 1455             


Leu Gly  Gln Lys Gly Ser Lys  Gly Ser Pro Gly Ser  Met Gly Pro 
    1460                 1465                 1470             


Arg Gly  Asp Thr Gly Pro Ala  Gly Pro Pro Gly Pro  Pro Gly Ala 
    1475                 1480                 1485             


Pro Ala  Glu Leu His Gly Leu  Arg Arg Arg Arg Arg  Phe Val Pro 
    1490                 1495                 1500             


Val Pro  Leu Pro Val Val Glu  Gly Gly Leu Glu Glu  Val Leu Ala 
    1505                 1510                 1515             


Ser Leu  Thr Ser Leu Ser Leu  Glu Leu Glu Gln Leu  Arg Arg Pro 
    1520                 1525                 1530             


Pro Gly  Thr Ala Glu Arg Pro  Gly Leu Val Cys His  Glu Leu His 
    1535                 1540                 1545             


Arg Asn  His Pro His Leu Pro  Asp Gly Glu Tyr Trp  Ile Asp Pro 
    1550                 1555                 1560             


Asn Gln  Gly Cys Ala Arg Asp  Ser Phe Arg Val Phe  Cys Asn Phe 
    1565                 1570                 1575             


Thr Ala  Gly Gly Glu Thr Cys  Leu Tyr Pro Asp Lys  Lys Phe Glu 
    1580                 1585                 1590             


Ile Val  Lys Leu Ala Ser Trp  Ser Lys Glu Lys Pro  Gly Gly Trp 
    1595                 1600                 1605             


Tyr Ser  Thr Phe Arg Arg Gly  Lys Lys Phe Ser Tyr  Val Asp Ala 
    1610                 1615                 1620             


Asp Gly  Ser Pro Val Asn Val  Val Gln Leu Asn Phe  Leu Lys Leu 
    1625                 1630                 1635             


Leu Ser  Ala Thr Ala Arg Gln  Asn Phe Thr Tyr Ser  Cys Gln Asn 
    1640                 1645                 1650             


Ala Ala  Ala Trp Leu Asp Glu  Ala Thr Gly Asp Tyr  Ser His Ser 
    1655                 1660                 1665             


Ala Arg  Phe Leu Gly Thr Asn  Gly Glu Glu Leu Ser  Phe Asn Gln 
    1670                 1675                 1680             


Thr Thr  Ala Ala Thr Val Ser  Val Pro Gln Asp Gly  Cys Arg Leu 
    1685                 1690                 1695             


Arg Lys  Gly Gln Thr Lys Thr  Leu Phe Glu Phe Ser  Ser Ser Arg 
    1700                 1705                 1710             


Ala Gly  Phe Leu Pro Leu Trp  Asp Val Ala Ala Thr  Asp Phe Gly 
    1715                 1720                 1725             


Gln Thr  Asn Gln Lys Phe Gly  Phe Glu Leu Gly Pro  Val Cys Phe 
    1730                 1735                 1740             


Ser Ser  
    1745 


<210>  3321
<211>  1028
<212>  PRT
<213>  Homo Sapiens

<400>  3321

Met Arg Ala Ala Arg Ala Leu Leu Pro Leu Leu Leu Gln Ala Cys Trp 
1               5                   10                  15      


Thr Ala Ala Gln Asp Glu Pro Glu Thr Pro Arg Ala Val Ala Phe Gln 
            20                  25                  30          


Asp Cys Pro Val Asp Leu Phe Phe Val Leu Asp Thr Ser Glu Ser Val 
        35                  40                  45              


Ala Leu Arg Leu Lys Pro Tyr Gly Ala Leu Val Asp Lys Val Lys Ser 
    50                  55                  60                  


Phe Thr Lys Arg Phe Ile Asp Asn Leu Arg Asp Arg Tyr Tyr Arg Cys 
65                  70                  75                  80  


Asp Arg Asn Leu Val Trp Asn Ala Gly Ala Leu His Tyr Ser Asp Glu 
                85                  90                  95      


Val Glu Ile Ile Gln Gly Leu Thr Arg Met Pro Gly Gly Arg Asp Ala 
            100                 105                 110         


Leu Lys Ser Ser Val Asp Ala Val Lys Tyr Phe Gly Lys Gly Thr Tyr 
        115                 120                 125             


Thr Asp Cys Ala Ile Lys Lys Gly Leu Glu Gln Leu Leu Val Gly Gly 
    130                 135                 140                 


Ser His Leu Lys Glu Asn Lys Tyr Leu Ile Val Val Thr Asp Gly His 
145                 150                 155                 160 


Pro Leu Glu Gly Tyr Lys Glu Pro Cys Gly Gly Leu Glu Asp Ala Val 
                165                 170                 175     


Asn Glu Ala Lys His Leu Gly Val Lys Val Phe Ser Val Ala Ile Thr 
            180                 185                 190         


Pro Asp His Leu Glu Pro Arg Leu Ser Ile Ile Ala Thr Asp His Thr 
        195                 200                 205             


Tyr Arg Arg Asn Phe Thr Ala Ala Asp Trp Gly Gln Ser Arg Asp Ala 
    210                 215                 220                 


Glu Glu Ala Ile Ser Gln Thr Ile Asp Thr Ile Val Asp Met Ile Lys 
225                 230                 235                 240 


Asn Asn Val Glu Gln Val Cys Cys Ser Phe Glu Cys Gln Pro Ala Arg 
                245                 250                 255     


Gly Pro Pro Gly Leu Arg Gly Asp Pro Gly Phe Glu Gly Glu Arg Gly 
            260                 265                 270         


Lys Pro Gly Leu Pro Gly Glu Lys Gly Glu Ala Gly Asp Pro Gly Arg 
        275                 280                 285             


Pro Gly Asp Leu Gly Pro Val Gly Tyr Gln Gly Met Lys Gly Glu Lys 
    290                 295                 300                 


Gly Ser Arg Gly Glu Lys Gly Ser Arg Gly Pro Lys Gly Tyr Lys Gly 
305                 310                 315                 320 


Glu Lys Gly Lys Arg Gly Ile Asp Gly Val Asp Gly Val Lys Gly Glu 
                325                 330                 335     


Met Gly Tyr Pro Gly Leu Pro Gly Cys Lys Gly Ser Pro Gly Phe Asp 
            340                 345                 350         


Gly Ile Gln Gly Pro Pro Gly Pro Lys Gly Asp Pro Gly Ala Phe Gly 
        355                 360                 365             


Leu Lys Gly Glu Lys Gly Glu Pro Gly Ala Asp Gly Glu Ala Gly Arg 
    370                 375                 380                 


Pro Gly Ser Ser Gly Pro Ser Gly Asp Glu Gly Gln Pro Gly Glu Pro 
385                 390                 395                 400 


Gly Pro Pro Gly Glu Lys Gly Glu Ala Gly Asp Glu Gly Asn Pro Gly 
                405                 410                 415     


Pro Asp Gly Ala Pro Gly Glu Arg Gly Gly Pro Gly Glu Arg Gly Pro 
            420                 425                 430         


Arg Gly Thr Pro Gly Thr Arg Gly Pro Arg Gly Asp Pro Gly Glu Ala 
        435                 440                 445             


Gly Pro Gln Gly Asp Gln Gly Arg Glu Gly Pro Val Gly Val Pro Gly 
    450                 455                 460                 


Asp Pro Gly Glu Ala Gly Pro Ile Gly Pro Lys Gly Tyr Arg Gly Asp 
465                 470                 475                 480 


Glu Gly Pro Pro Gly Ser Glu Gly Ala Arg Gly Ala Pro Gly Pro Ala 
                485                 490                 495     


Gly Pro Pro Gly Asp Pro Gly Leu Met Gly Glu Arg Gly Glu Asp Gly 
            500                 505                 510         


Pro Ala Gly Asn Gly Thr Glu Gly Phe Pro Gly Phe Pro Gly Tyr Pro 
        515                 520                 525             


Gly Asn Arg Gly Ala Pro Gly Ile Asn Gly Thr Lys Gly Tyr Pro Gly 
    530                 535                 540                 


Leu Lys Gly Asp Glu Gly Glu Ala Gly Asp Pro Gly Asp Asp Asn Asn 
545                 550                 555                 560 


Asp Ile Ala Pro Arg Gly Val Lys Gly Ala Lys Gly Tyr Arg Gly Pro 
                565                 570                 575     


Glu Gly Pro Gln Gly Pro Pro Gly His Gln Gly Pro Pro Gly Pro Asp 
            580                 585                 590         


Glu Cys Glu Ile Leu Asp Ile Ile Met Lys Met Cys Ser Cys Cys Glu 
        595                 600                 605             


Cys Lys Cys Gly Pro Ile Asp Leu Leu Phe Val Leu Asp Ser Ser Glu 
    610                 615                 620                 


Ser Ile Gly Leu Gln Asn Phe Glu Ile Ala Lys Asp Phe Val Val Lys 
625                 630                 635                 640 


Val Ile Asp Arg Leu Ser Arg Asp Glu Leu Val Lys Phe Glu Pro Gly 
                645                 650                 655     


Gln Ser Tyr Ala Gly Val Val Gln Tyr Ser His Ser Gln Met Gln Glu 
            660                 665                 670         


His Val Ser Leu Arg Ser Pro Ser Ile Arg Asn Val Gln Glu Leu Lys 
        675                 680                 685             


Glu Ala Ile Lys Ser Leu Gln Trp Met Ala Gly Gly Thr Phe Thr Gly 
    690                 695                 700                 


Glu Ala Leu Gln Tyr Thr Arg Asp Gln Leu Leu Pro Pro Ser Pro Asn 
705                 710                 715                 720 


Asn Arg Ile Ala Leu Val Ile Thr Asp Gly Arg Ser Asp Thr Gln Arg 
                725                 730                 735     


Asp Thr Thr Pro Leu Asn Val Leu Cys Ser Pro Gly Ile Gln Val Val 
            740                 745                 750         


Ser Val Gly Ile Lys Asp Val Phe Asp Phe Ile Pro Gly Ser Asp Gln 
        755                 760                 765             


Leu Asn Val Ile Ser Cys Gln Gly Leu Ala Pro Ser Gln Gly Arg Pro 
    770                 775                 780                 


Gly Leu Ser Leu Val Lys Glu Asn Tyr Ala Glu Leu Leu Glu Asp Ala 
785                 790                 795                 800 


Phe Leu Lys Asn Val Thr Ala Gln Ile Cys Ile Asp Lys Lys Cys Pro 
                805                 810                 815     


Asp Tyr Thr Cys Pro Ile Thr Phe Ser Ser Pro Ala Asp Ile Thr Ile 
            820                 825                 830         


Leu Leu Asp Gly Ser Ala Ser Val Gly Ser His Asn Phe Asp Thr Thr 
        835                 840                 845             


Lys Arg Phe Ala Lys Arg Leu Ala Glu Arg Phe Leu Thr Ala Gly Arg 
    850                 855                 860                 


Thr Asp Pro Ala His Asp Val Arg Val Ala Val Val Gln Tyr Ser Gly 
865                 870                 875                 880 


Thr Gly Gln Gln Arg Pro Glu Arg Ala Ser Leu Gln Phe Leu Gln Asn 
                885                 890                 895     


Tyr Thr Ala Leu Ala Ser Ala Val Asp Ala Met Asp Phe Ile Asn Asp 
            900                 905                 910         


Ala Thr Asp Val Asn Asp Ala Leu Gly Tyr Val Thr Arg Phe Tyr Arg 
        915                 920                 925             


Glu Ala Ser Ser Gly Ala Ala Lys Lys Arg Leu Leu Leu Phe Ser Asp 
    930                 935                 940                 


Gly Asn Ser Gln Gly Ala Thr Pro Ala Ala Ile Glu Lys Ala Val Gln 
945                 950                 955                 960 


Glu Ala Gln Arg Ala Gly Ile Glu Ile Phe Val Val Val Val Gly Arg 
                965                 970                 975     


Gln Val Asn Glu Pro His Ile Arg Val Leu Val Thr Gly Lys Thr Ala 
            980                 985                 990         


Glu Tyr Asp Val Ala Tyr Gly Glu  Ser His Leu Phe Arg  Val Pro Ser 
        995                 1000                 1005             


Tyr Gln  Ala Leu Leu Arg Gly  Val Phe His Gln Thr  Val Ser Arg 
    1010                 1015                 1020             


Lys Val  Ala Leu Gly 
    1025             


<210>  3322
<211>  1026
<212>  PRT
<213>  Homo Sapiens

<400>  3322

Met Arg Ala Ala Arg Ala Leu Leu Pro Leu Leu Leu Gln Ala Cys Trp 
1               5                   10                  15      


Thr Ala Ala Gln Asp Glu Pro Glu Thr Pro Arg Ala Val Ala Phe Gln 
            20                  25                  30          


Asp Cys Pro Val Asp Leu Phe Phe Val Leu Asp Thr Ser Glu Ser Val 
        35                  40                  45              


Ala Leu Arg Leu Lys Pro Tyr Gly Ala Leu Val Asp Lys Val Lys Ser 
    50                  55                  60                  


Phe Thr Lys Arg Phe Ile Asp Asn Leu Arg Asp Arg Tyr Tyr Arg Cys 
65                  70                  75                  80  


Asp Arg Asn Leu Val Trp Asn Ala Gly Ala Leu His Tyr Ser Asp Glu 
                85                  90                  95      


Val Glu Ile Ile Gln Gly Leu Thr Arg Met Pro Gly Gly Arg Asp Ala 
            100                 105                 110         


Leu Lys Ser Ser Val Asp Ala Val Lys Tyr Phe Gly Lys Gly Thr Tyr 
        115                 120                 125             


Thr Asp Cys Ala Ile Lys Lys Gly Leu Glu Gln Leu Leu Val Gly Gly 
    130                 135                 140                 


Ser His Leu Lys Glu Asn Lys Tyr Leu Ile Val Val Thr Asp Gly His 
145                 150                 155                 160 


Pro Leu Glu Gly Tyr Lys Glu Pro Cys Gly Gly Leu Glu Asp Ala Val 
                165                 170                 175     


Asn Glu Ala Lys His Leu Gly Val Lys Val Phe Ser Val Ala Ile Thr 
            180                 185                 190         


Pro Asp His Leu Glu Pro Arg Leu Ser Ile Ile Ala Thr Asp His Thr 
        195                 200                 205             


Tyr Arg Arg Asn Phe Thr Ala Ala Asp Trp Gly Gln Ser Arg Asp Ala 
    210                 215                 220                 


Glu Glu Ala Ile Ser Gln Thr Ile Asp Thr Ile Val Asp Met Ile Lys 
225                 230                 235                 240 


Asn Asn Val Glu Gln Val Cys Cys Ser Phe Glu Cys Gln Pro Ala Arg 
                245                 250                 255     


Gly Pro Pro Gly Leu Arg Gly Asp Pro Gly Phe Glu Gly Glu Arg Gly 
            260                 265                 270         


Lys Pro Gly Leu Pro Gly Glu Lys Gly Glu Ala Gly Asp Pro Gly Arg 
        275                 280                 285             


Pro Gly Asp Leu Gly Pro Val Gly Tyr Gln Gly Met Lys Gly Glu Lys 
    290                 295                 300                 


Gly Ser Arg Gly Glu Lys Gly Ser Arg Gly Pro Lys Gly Tyr Lys Gly 
305                 310                 315                 320 


Glu Lys Gly Lys Arg Gly Ile Asp Gly Val Asp Gly Val Lys Gly Glu 
                325                 330                 335     


Met Gly Tyr Pro Gly Leu Pro Gly Cys Lys Gly Ser Pro Gly Phe Asp 
            340                 345                 350         


Gly Ile Gln Gly Pro Pro Gly Pro Lys Gly Asp Pro Gly Ala Phe Gly 
        355                 360                 365             


Leu Lys Gly Glu Lys Gly Glu Pro Gly Ala Asp Gly Glu Ala Gly Arg 
    370                 375                 380                 


Pro Gly Ser Ser Gly Pro Ser Gly Asp Glu Gly Gln Pro Gly Glu Pro 
385                 390                 395                 400 


Gly Pro Pro Gly Glu Lys Gly Glu Ala Gly Asp Glu Gly Asn Pro Gly 
                405                 410                 415     


Pro Asp Gly Ala Pro Gly Glu Arg Gly Gly Pro Gly Glu Arg Gly Pro 
            420                 425                 430         


Arg Gly Thr Pro Gly Thr Arg Gly Pro Arg Gly Asp Pro Gly Glu Ala 
        435                 440                 445             


Gly Pro Gln Gly Asp Gln Gly Arg Glu Gly Pro Val Gly Val Pro Gly 
    450                 455                 460                 


Asp Pro Gly Glu Ala Gly Pro Ile Gly Pro Lys Gly Tyr Arg Gly Asp 
465                 470                 475                 480 


Glu Gly Pro Pro Gly Ser Glu Gly Ala Arg Gly Ala Pro Gly Pro Ala 
                485                 490                 495     


Gly Pro Pro Gly Asp Pro Gly Leu Met Gly Glu Arg Gly Glu Asp Gly 
            500                 505                 510         


Pro Ala Gly Asn Gly Thr Glu Gly Phe Pro Gly Phe Pro Gly Tyr Pro 
        515                 520                 525             


Gly Asn Arg Gly Ala Pro Gly Ile Asn Gly Thr Lys Gly Tyr Pro Gly 
    530                 535                 540                 


Leu Lys Gly Asp Glu Gly Glu Ala Gly Asp Pro Gly Asp Asp Asn Asn 
545                 550                 555                 560 


Asp Ile Ala Pro Arg Gly Val Lys Gly Ala Lys Gly Tyr Arg Gly Pro 
                565                 570                 575     


Glu Gly Pro Gln Gly Pro Pro Gly His Gln Gly Pro Pro Gly Pro Asp 
            580                 585                 590         


Glu Cys Glu Ile Leu Asp Ile Ile Met Lys Met Cys Cys Glu Cys Lys 
        595                 600                 605             


Cys Gly Pro Ile Asp Leu Leu Phe Val Leu Asp Ser Ser Glu Ser Ile 
    610                 615                 620                 


Gly Leu Gln Asn Phe Glu Ile Ala Lys Asp Phe Val Val Lys Val Ile 
625                 630                 635                 640 


Asp Arg Leu Ser Arg Asp Glu Leu Val Lys Phe Glu Pro Gly Gln Ser 
                645                 650                 655     


Tyr Ala Gly Val Val Gln Tyr Ser His Ser Gln Met Gln Glu His Val 
            660                 665                 670         


Ser Leu Arg Ser Pro Ser Ile Arg Asn Val Gln Glu Leu Lys Glu Ala 
        675                 680                 685             


Ile Lys Ser Leu Gln Trp Met Ala Gly Gly Thr Phe Thr Gly Glu Ala 
    690                 695                 700                 


Leu Gln Tyr Thr Arg Asp Gln Leu Leu Pro Pro Ser Pro Asn Asn Arg 
705                 710                 715                 720 


Ile Ala Leu Val Ile Thr Asp Gly Arg Ser Asp Thr Gln Arg Asp Thr 
                725                 730                 735     


Thr Pro Leu Asn Val Leu Cys Ser Pro Gly Ile Gln Val Val Ser Val 
            740                 745                 750         


Gly Ile Lys Asp Val Phe Asp Phe Ile Pro Gly Ser Asp Gln Leu Asn 
        755                 760                 765             


Val Ile Ser Cys Gln Gly Leu Ala Pro Ser Gln Gly Arg Pro Gly Leu 
    770                 775                 780                 


Ser Leu Val Lys Glu Asn Tyr Ala Glu Leu Leu Glu Asp Ala Phe Leu 
785                 790                 795                 800 


Lys Asn Val Thr Ala Gln Ile Cys Ile Asp Lys Lys Cys Pro Asp Tyr 
                805                 810                 815     


Thr Cys Pro Ile Thr Phe Ser Ser Pro Ala Asp Ile Thr Ile Leu Leu 
            820                 825                 830         


Asp Gly Ser Ala Ser Val Gly Ser His Asn Phe Asp Thr Thr Lys Arg 
        835                 840                 845             


Phe Ala Lys Arg Leu Ala Glu Arg Phe Leu Thr Ala Gly Arg Thr Asp 
    850                 855                 860                 


Pro Ala His Asp Val Arg Val Ala Val Val Gln Tyr Ser Gly Thr Gly 
865                 870                 875                 880 


Gln Gln Arg Pro Glu Arg Ala Ser Leu Gln Phe Leu Gln Asn Tyr Thr 
                885                 890                 895     


Ala Leu Ala Ser Ala Val Asp Ala Met Asp Phe Ile Asn Asp Ala Thr 
            900                 905                 910         


Asp Val Asn Asp Ala Leu Gly Tyr Val Thr Arg Phe Tyr Arg Glu Ala 
        915                 920                 925             


Ser Ser Gly Ala Ala Lys Lys Arg Leu Leu Leu Phe Ser Asp Gly Asn 
    930                 935                 940                 


Ser Gln Gly Ala Thr Pro Ala Ala Ile Glu Lys Ala Val Gln Glu Ala 
945                 950                 955                 960 


Gln Arg Ala Gly Ile Glu Ile Phe Val Val Val Val Gly Arg Gln Val 
                965                 970                 975     


Asn Glu Pro His Ile Arg Val Leu Val Thr Gly Lys Thr Ala Glu Tyr 
            980                 985                 990         


Asp Val Ala Tyr Gly Glu Ser His  Leu Phe Arg Val Pro  Ser Tyr Gln 
        995                 1000                 1005             


Ala Leu  Leu Arg Gly Val Phe  His Gln Thr Val Ser  Arg Lys Val 
    1010                 1015                 1020             


Ala Leu  Gly 
    1025     


<210>  3323
<211>  250
<212>  PRT
<213>  Homo Sapiens

<400>  3323

Gly Asn Lys Gly Ala Lys Gly Asp Arg Gly Leu Pro Gly Pro Arg Gly 
1               5                   10                  15      


Pro Gln Gly Ala Leu Gly Glu Pro Gly Lys Gln Gly Ser Arg Gly Asp 
            20                  25                  30          


Pro Gly Asp Ala Gly Pro Arg Gly Asp Ser Gly Gln Pro Gly Pro Lys 
        35                  40                  45              


Gly Asp Pro Gly Arg Pro Gly Phe Ser Tyr Pro Gly Pro Arg Gly Ala 
    50                  55                  60                  


Pro Gly Glu Lys Gly Glu Pro Gly Pro Arg Gly Pro Glu Gly Gly Arg 
65                  70                  75                  80  


Gly Asp Phe Gly Leu Lys Gly Glu Pro Gly Arg Lys Gly Glu Lys Gly 
                85                  90                  95      


Glu Pro Ala Asp Pro Gly Pro Pro Gly Glu Pro Gly Pro Arg Gly Pro 
            100                 105                 110         


Arg Gly Val Pro Gly Pro Glu Gly Glu Pro Gly Pro Pro Gly Asp Pro 
        115                 120                 125             


Gly Leu Thr Glu Cys Asp Val Met Thr Tyr Val Arg Glu Thr Cys Gly 
    130                 135                 140                 


Cys Cys Gly Ser Glu Val Ser Pro Val Pro Pro Asp Asp Pro Ala Thr 
145                 150                 155                 160 


Pro Pro Asp Cys Glu Lys Arg Cys Gly Ala Leu Asp Val Val Phe Val 
                165                 170                 175     


Ile Asp Ser Ser Glu Ser Ile Gly Tyr Thr Asn Phe Thr Leu Glu Lys 
            180                 185                 190         


Asn Phe Val Ile Asn Val Val Asn Arg Leu Gly Ala Ile Ala Lys Asp 
        195                 200                 205             


Pro Lys Ser Glu Thr Gly Thr Arg Val Gly Val Val Gln Tyr Ser His 
    210                 215                 220                 


Glu Gly Thr Phe Glu Ala Ile Gln Leu Asp Asp Glu Arg Ile Asp Ser 
225                 230                 235                 240 


Leu Ser Ser Phe Lys Glu Ala Val Lys Asn 
                245                 250 


<210>  3324
<211>  180
<212>  PRT
<213>  Homo Sapiens

<400>  3324

Met Leu Gln Gly Thr Cys Ser Val Leu Leu Leu Trp Gly Ile Leu Gly 
1               5                   10                  15      


Ala Ile Gln Ala Gln Gln Gln Glu Val Ile Ser Pro Asp Thr Thr Glu 
            20                  25                  30          


Arg Asn Asn Asn Cys Pro Glu Lys Thr Asp Cys Pro Ile His Val Tyr 
        35                  40                  45              


Phe Val Leu Asp Thr Ser Glu Ser Val Thr Met Gln Ser Pro Thr Asp 
    50                  55                  60                  


Ile Leu Leu Phe His Met Lys Gln Phe Val Pro Gln Phe Ile Ser Gln 
65                  70                  75                  80  


Leu Gln Asn Glu Phe Tyr Leu Asp Gln Val Ala Leu Ser Trp Arg Tyr 
                85                  90                  95      


Gly Gly Leu His Phe Ser Asp Gln Val Glu Val Phe Ser Pro Pro Gly 
            100                 105                 110         


Ser Asp Arg Ala Ser Phe Ile Lys Asn Leu Gln Gly Ile Ser Ser Phe 
        115                 120                 125             


Arg Arg Gly Thr Phe Thr Asp Cys Ala Leu Ala Asn Met Thr Glu Gln 
    130                 135                 140                 


Ile Arg Gln Asp Arg Ser Lys Gly Thr Val His Phe Ala Val Val Ile 
145                 150                 155                 160 


Thr Asp Gly His Val Thr Gly Ser Pro Cys Gly Gly Ile Lys Leu Gln 
                165                 170                 175     


Ala Glu Arg Ala 
            180 


<210>  3325
<211>  1019
<212>  PRT
<213>  Homo Sapiens

<400>  3325

Met Leu Gln Gly Thr Cys Ser Val Leu Leu Leu Trp Gly Ile Leu Gly 
1               5                   10                  15      


Ala Ile Gln Ala Gln Gln Gln Glu Val Ile Ser Pro Asp Thr Thr Glu 
            20                  25                  30          


Arg Asn Asn Asn Cys Pro Glu Lys Thr Asp Cys Pro Ile His Val Tyr 
        35                  40                  45              


Phe Val Leu Asp Thr Ser Glu Ser Val Thr Met Gln Ser Pro Thr Asp 
    50                  55                  60                  


Ile Leu Leu Phe His Met Lys Gln Phe Val Pro Gln Phe Ile Ser Gln 
65                  70                  75                  80  


Leu Gln Asn Glu Phe Tyr Leu Asp Gln Val Ala Leu Ser Trp Arg Tyr 
                85                  90                  95      


Gly Gly Leu His Phe Ser Asp Gln Val Glu Val Phe Ser Pro Pro Gly 
            100                 105                 110         


Ser Asp Arg Ala Ser Phe Ile Lys Asn Leu Gln Gly Ile Ser Ser Phe 
        115                 120                 125             


Arg Arg Gly Thr Phe Thr Asp Cys Ala Leu Ala Asn Met Thr Glu Gln 
    130                 135                 140                 


Ile Arg Gln Asp Arg Ser Lys Gly Thr Val His Phe Ala Val Val Ile 
145                 150                 155                 160 


Thr Asp Gly His Val Thr Gly Ser Pro Cys Gly Gly Ile Lys Leu Gln 
                165                 170                 175     


Ala Glu Arg Ala Arg Glu Glu Gly Ile Arg Leu Phe Ala Val Ala Pro 
            180                 185                 190         


Asn Gln Asn Leu Lys Glu Gln Gly Leu Arg Asp Ile Ala Ser Thr Pro 
        195                 200                 205             


His Glu Leu Tyr Arg Asn Asp Tyr Ala Thr Met Leu Pro Asp Ser Thr 
    210                 215                 220                 


Glu Ile Asp Gln Asp Thr Ile Asn Arg Ile Ile Lys Val Met Lys His 
225                 230                 235                 240 


Glu Ala Tyr Gly Glu Cys Tyr Lys Val Ser Cys Leu Glu Ile Pro Gly 
                245                 250                 255     


Pro Ser Gly Pro Lys Gly Tyr Arg Gly Gln Lys Gly Ala Lys Gly Asn 
            260                 265                 270         


Met Gly Glu Pro Gly Glu Pro Gly Gln Lys Gly Arg Gln Gly Asp Pro 
        275                 280                 285             


Gly Ile Glu Gly Pro Ile Gly Phe Pro Gly Pro Lys Gly Val Pro Gly 
    290                 295                 300                 


Phe Lys Gly Glu Lys Gly Glu Phe Gly Ala Asp Gly Arg Lys Gly Ala 
305                 310                 315                 320 


Pro Gly Leu Ala Gly Lys Asn Gly Thr Asp Gly Gln Lys Gly Lys Leu 
                325                 330                 335     


Gly Arg Ile Gly Pro Pro Gly Cys Lys Gly Asp Pro Gly Asn Arg Gly 
            340                 345                 350         


Pro Asp Gly Tyr Pro Gly Glu Ala Gly Ser Pro Gly Glu Arg Gly Asp 
        355                 360                 365             


Gln Gly Gly Lys Gly Asp Pro Gly Arg Pro Gly Arg Arg Gly Pro Pro 
    370                 375                 380                 


Gly Glu Ile Gly Ala Lys Gly Ser Lys Gly Tyr Gln Gly Asn Ser Gly 
385                 390                 395                 400 


Ala Pro Gly Ser Pro Gly Val Lys Gly Ala Lys Gly Gly Pro Gly Pro 
                405                 410                 415     


Arg Gly Pro Lys Gly Glu Pro Gly Arg Arg Gly Asp Pro Gly Thr Lys 
            420                 425                 430         


Gly Ser Pro Gly Ser Asp Gly Pro Lys Gly Glu Lys Gly Asp Pro Gly 
        435                 440                 445             


Pro Glu Gly Pro Arg Gly Leu Ala Gly Glu Val Gly Asn Lys Gly Ala 
    450                 455                 460                 


Lys Gly Asp Arg Gly Leu Pro Gly Pro Arg Gly Pro Gln Gly Ala Leu 
465                 470                 475                 480 


Gly Glu Pro Gly Lys Gln Gly Ser Arg Gly Asp Pro Gly Asp Ala Gly 
                485                 490                 495     


Pro Arg Gly Asp Ser Gly Gln Pro Gly Pro Lys Gly Asp Pro Gly Arg 
            500                 505                 510         


Pro Gly Phe Ser Tyr Pro Gly Pro Arg Gly Ala Pro Gly Glu Lys Gly 
        515                 520                 525             


Glu Pro Gly Pro Arg Gly Pro Glu Gly Gly Arg Gly Asp Phe Gly Leu 
    530                 535                 540                 


Lys Gly Glu Pro Gly Arg Lys Gly Glu Lys Gly Glu Pro Ala Asp Pro 
545                 550                 555                 560 


Gly Pro Pro Gly Glu Pro Gly Pro Arg Gly Pro Arg Gly Val Pro Gly 
                565                 570                 575     


Pro Glu Gly Glu Pro Gly Pro Pro Gly Asp Pro Gly Leu Thr Glu Cys 
            580                 585                 590         


Asp Val Met Thr Tyr Val Arg Glu Thr Cys Gly Cys Cys Asp Cys Glu 
        595                 600                 605             


Lys Arg Cys Gly Ala Leu Asp Val Val Phe Val Ile Asp Ser Ser Glu 
    610                 615                 620                 


Ser Ile Gly Tyr Thr Asn Phe Thr Leu Glu Lys Asn Phe Val Ile Asn 
625                 630                 635                 640 


Val Val Asn Arg Leu Gly Ala Ile Ala Lys Asp Pro Lys Ser Glu Thr 
                645                 650                 655     


Gly Thr Arg Val Gly Val Val Gln Tyr Ser His Glu Gly Thr Phe Glu 
            660                 665                 670         


Ala Ile Gln Leu Asp Asp Glu Arg Ile Asp Ser Leu Ser Ser Phe Lys 
        675                 680                 685             


Glu Ala Val Lys Asn Leu Glu Trp Ile Ala Gly Gly Thr Trp Thr Pro 
    690                 695                 700                 


Ser Ala Leu Lys Phe Ala Tyr Asp Arg Leu Ile Lys Glu Ser Arg Arg 
705                 710                 715                 720 


Gln Lys Thr Arg Val Phe Ala Val Val Ile Thr Asp Gly Arg His Asp 
                725                 730                 735     


Pro Arg Asp Asp Asp Leu Asn Leu Arg Ala Leu Cys Asp Arg Asp Val 
            740                 745                 750         


Thr Val Thr Ala Ile Gly Ile Gly Asp Met Phe His Glu Lys His Glu 
        755                 760                 765             


Ser Glu Asn Leu Tyr Ser Ile Ala Cys Asp Lys Pro Gln Gln Val Arg 
    770                 775                 780                 


Asn Met Thr Leu Phe Ser Asp Leu Val Ala Glu Lys Phe Ile Asp Asp 
785                 790                 795                 800 


Met Glu Asp Val Leu Cys Pro Asp Pro Gln Ile Val Cys Pro Asp Leu 
                805                 810                 815     


Pro Cys Gln Thr Glu Leu Ser Val Ala Gln Cys Thr Gln Arg Pro Val 
            820                 825                 830         


Asp Ile Val Phe Leu Leu Asp Gly Ser Glu Arg Leu Gly Glu Gln Asn 
        835                 840                 845             


Phe His Lys Ala Arg Arg Phe Val Glu Gln Val Ala Arg Arg Leu Thr 
    850                 855                 860                 


Leu Ala Arg Arg Asp Asp Asp Pro Leu Asn Ala Arg Val Ala Leu Leu 
865                 870                 875                 880 


Gln Phe Gly Gly Pro Gly Glu Gln Gln Val Ala Phe Pro Leu Ser His 
                885                 890                 895     


Asn Leu Thr Ala Ile His Glu Ala Leu Glu Thr Thr Gln Tyr Leu Asn 
            900                 905                 910         


Ser Phe Ser His Val Gly Ala Gly Val Val His Ala Ile Asn Ala Ile 
        915                 920                 925             


Val Arg Ser Pro Arg Gly Gly Ala Arg Arg His Ala Glu Leu Ser Phe 
    930                 935                 940                 


Val Phe Leu Thr Asp Gly Val Thr Gly Asn Asp Ser Leu His Glu Ser 
945                 950                 955                 960 


Ala His Ser Met Arg Lys Gln Asn Val Val Pro Thr Val Leu Ala Leu 
                965                 970                 975     


Gly Ser Asp Val Asp Met Asp Val Leu Thr Thr Leu Ser Leu Gly Asp 
            980                 985                 990         


Arg Ala Ala Val Phe His Glu Lys  Asp Tyr Asp Ser Leu  Ala Gln Pro 
        995                 1000                 1005             


Gly Phe  Phe Asp Arg Phe Ile  Arg Trp Ile Cys 
    1010                 1015                 


<210>  3326
<211>  828
<212>  PRT
<213>  Homo Sapiens

<400>  3326

Met Leu Gln Gly Thr Cys Ser Val Leu Leu Leu Trp Gly Ile Leu Gly 
1               5                   10                  15      


Ala Ile Gln Ala Gln Gln Gln Glu Val Ile Ser Pro Asp Thr Thr Glu 
            20                  25                  30          


Arg Asn Asn Asn Cys Pro Glu Lys Thr Asp Cys Pro Ile His Val Tyr 
        35                  40                  45              


Phe Val Leu Asp Thr Ser Glu Ser Val Thr Met Gln Ser Pro Thr Asp 
    50                  55                  60                  


Ile Leu Leu Phe His Met Lys Gln Phe Val Pro Gln Phe Ile Ser Gln 
65                  70                  75                  80  


Leu Gln Asn Glu Phe Tyr Leu Asp Gln Val Ala Leu Ser Trp Arg Tyr 
                85                  90                  95      


Gly Gly Leu His Phe Ser Asp Gln Val Glu Val Phe Ser Pro Pro Gly 
            100                 105                 110         


Ser Asp Arg Ala Ser Phe Ile Lys Asn Leu Gln Gly Ile Ser Ser Phe 
        115                 120                 125             


Arg Arg Gly Thr Phe Thr Asp Cys Ala Leu Ala Asn Met Thr Glu Gln 
    130                 135                 140                 


Ile Arg Gln Asp Arg Ser Lys Gly Thr Val His Phe Ala Val Val Ile 
145                 150                 155                 160 


Thr Asp Gly His Val Thr Gly Ser Pro Cys Gly Gly Ile Lys Leu Gln 
                165                 170                 175     


Ala Glu Arg Ala Arg Glu Glu Gly Ile Arg Leu Phe Ala Val Ala Pro 
            180                 185                 190         


Asn Gln Asn Leu Lys Glu Gln Gly Leu Arg Asp Ile Ala Ser Thr Pro 
        195                 200                 205             


His Glu Leu Tyr Arg Asn Asp Tyr Ala Thr Met Leu Pro Asp Ser Thr 
    210                 215                 220                 


Glu Ile Asp Gln Asp Thr Ile Asn Arg Ile Ile Lys Val Met Lys His 
225                 230                 235                 240 


Glu Ala Tyr Gly Glu Cys Tyr Lys Val Ser Cys Leu Glu Ile Pro Gly 
                245                 250                 255     


Pro Ser Gly Pro Lys Gly Tyr Arg Gly Gln Lys Gly Ala Lys Gly Asn 
            260                 265                 270         


Met Gly Glu Pro Gly Glu Pro Gly Gln Lys Gly Arg Gln Gly Asp Pro 
        275                 280                 285             


Gly Ile Glu Gly Pro Ile Gly Phe Pro Gly Pro Lys Gly Val Pro Gly 
    290                 295                 300                 


Phe Lys Gly Glu Lys Gly Glu Phe Gly Ala Asp Gly Arg Lys Gly Ala 
305                 310                 315                 320 


Pro Gly Leu Ala Gly Lys Asn Gly Thr Asp Gly Gln Lys Gly Lys Leu 
                325                 330                 335     


Gly Arg Ile Gly Pro Pro Gly Cys Lys Gly Asp Pro Gly Asn Arg Gly 
            340                 345                 350         


Pro Asp Gly Tyr Pro Gly Glu Ala Gly Ser Pro Gly Glu Arg Gly Asp 
        355                 360                 365             


Gln Gly Gly Lys Gly Asp Pro Gly Arg Pro Gly Arg Arg Gly Pro Pro 
    370                 375                 380                 


Gly Glu Ile Gly Ala Lys Gly Ser Lys Gly Tyr Gln Gly Asn Ser Gly 
385                 390                 395                 400 


Ala Pro Gly Ser Pro Gly Val Lys Gly Ala Lys Gly Gly Pro Gly Pro 
                405                 410                 415     


Arg Gly Pro Lys Gly Glu Pro Gly Arg Arg Gly Asp Pro Gly Thr Lys 
            420                 425                 430         


Gly Ser Pro Gly Ser Asp Gly Pro Lys Gly Glu Lys Gly Asp Pro Gly 
        435                 440                 445             


Pro Glu Gly Pro Arg Gly Leu Ala Gly Glu Val Gly Asn Lys Gly Ala 
    450                 455                 460                 


Lys Gly Asp Arg Gly Leu Pro Gly Pro Arg Gly Pro Gln Gly Ala Leu 
465                 470                 475                 480 


Gly Glu Pro Gly Lys Gln Gly Ser Arg Gly Asp Pro Gly Asp Ala Gly 
                485                 490                 495     


Pro Arg Gly Asp Ser Gly Gln Pro Gly Pro Lys Gly Asp Pro Gly Arg 
            500                 505                 510         


Pro Gly Phe Ser Tyr Pro Gly Pro Arg Gly Ala Pro Gly Glu Lys Gly 
        515                 520                 525             


Glu Pro Gly Pro Arg Gly Pro Glu Gly Gly Arg Gly Asp Phe Gly Leu 
    530                 535                 540                 


Lys Gly Glu Pro Gly Arg Lys Gly Glu Lys Gly Glu Pro Ala Asp Pro 
545                 550                 555                 560 


Gly Pro Pro Gly Glu Pro Gly Pro Arg Gly Pro Arg Gly Val Pro Gly 
                565                 570                 575     


Pro Glu Gly Glu Pro Gly Pro Pro Gly Asp Pro Gly Leu Thr Glu Cys 
            580                 585                 590         


Asp Val Met Thr Tyr Val Arg Glu Thr Cys Gly Cys Cys Asp Cys Glu 
        595                 600                 605             


Lys Arg Cys Gly Ala Leu Asp Val Val Phe Val Ile Asp Ser Ser Glu 
    610                 615                 620                 


Ser Ile Gly Tyr Thr Asn Phe Thr Leu Glu Lys Asn Phe Val Ile Asn 
625                 630                 635                 640 


Val Val Asn Arg Leu Gly Ala Ile Ala Lys Asp Pro Lys Ser Glu Thr 
                645                 650                 655     


Gly Thr Arg Val Gly Val Val Gln Tyr Ser His Glu Gly Thr Phe Glu 
            660                 665                 670         


Ala Ile Gln Leu Asp Asp Glu Arg Ile Asp Ser Leu Ser Ser Phe Lys 
        675                 680                 685             


Glu Ala Val Lys Asn Leu Glu Trp Ile Ala Gly Gly Thr Trp Thr Pro 
    690                 695                 700                 


Ser Ala Leu Lys Phe Ala Tyr Asp Arg Leu Ile Lys Glu Ser Arg Arg 
705                 710                 715                 720 


Gln Lys Thr Arg Val Phe Ala Val Val Ile Thr Asp Gly Arg His Asp 
                725                 730                 735     


Pro Arg Asp Asp Asp Leu Asn Leu Arg Ala Leu Cys Asp Arg Asp Val 
            740                 745                 750         


Thr Val Thr Ala Ile Gly Ile Gly Asp Met Phe His Glu Lys His Glu 
        755                 760                 765             


Ser Glu Asn Leu Tyr Ser Ile Ala Cys Asp Lys Pro Gln Gln Val Arg 
    770                 775                 780                 


Asn Met Thr Leu Phe Ser Asp Leu Val Ala Glu Lys Phe Ile Asp Asp 
785                 790                 795                 800 


Met Glu Asp Val Leu Cys Pro Asp Pro Gln Ile Val Cys Pro Asp Leu 
                805                 810                 815     


Pro Cys Gln Thr Gly Leu Asp Gly Ala Val Leu Cys 
            820                 825             


<210>  3327
<211>  918
<212>  PRT
<213>  Homo Sapiens

<400>  3327

Met Leu Gln Gly Thr Cys Ser Val Leu Leu Leu Trp Gly Ile Leu Gly 
1               5                   10                  15      


Ala Ile Gln Ala Gln Gln Gln Glu Val Ile Ser Pro Asp Thr Thr Glu 
            20                  25                  30          


Arg Asn Asn Asn Cys Pro Glu Lys Thr Asp Cys Pro Ile His Val Tyr 
        35                  40                  45              


Phe Val Leu Asp Thr Ser Glu Ser Val Thr Met Gln Ser Pro Thr Asp 
    50                  55                  60                  


Ile Leu Leu Phe His Met Lys Gln Phe Val Pro Gln Phe Ile Ser Gln 
65                  70                  75                  80  


Leu Gln Asn Glu Phe Tyr Leu Asp Gln Val Ala Leu Ser Trp Arg Tyr 
                85                  90                  95      


Gly Gly Leu His Phe Ser Asp Gln Val Glu Val Phe Ser Pro Pro Gly 
            100                 105                 110         


Ser Asp Arg Ala Ser Phe Ile Lys Asn Leu Gln Gly Ile Ser Ser Phe 
        115                 120                 125             


Arg Arg Gly Thr Phe Thr Asp Cys Ala Leu Ala Asn Met Thr Glu Gln 
    130                 135                 140                 


Ile Arg Gln Asp Arg Ser Lys Gly Thr Val His Phe Ala Val Val Ile 
145                 150                 155                 160 


Thr Asp Gly His Val Thr Gly Ser Pro Cys Gly Gly Ile Lys Leu Gln 
                165                 170                 175     


Ala Glu Arg Ala Arg Glu Glu Gly Ile Arg Leu Phe Ala Val Ala Pro 
            180                 185                 190         


Asn Gln Asn Leu Lys Glu Gln Gly Leu Arg Asp Ile Ala Ser Thr Pro 
        195                 200                 205             


His Glu Leu Tyr Arg Asn Asp Tyr Ala Thr Met Leu Pro Asp Ser Thr 
    210                 215                 220                 


Glu Ile Asp Gln Asp Thr Ile Asn Arg Ile Ile Lys Val Met Lys His 
225                 230                 235                 240 


Glu Ala Tyr Gly Glu Cys Tyr Lys Val Ser Cys Leu Glu Ile Pro Gly 
                245                 250                 255     


Pro Ser Gly Pro Lys Gly Tyr Arg Gly Gln Lys Gly Ala Lys Gly Asn 
            260                 265                 270         


Met Gly Glu Pro Gly Glu Pro Gly Gln Lys Gly Arg Gln Gly Asp Pro 
        275                 280                 285             


Gly Ile Glu Gly Pro Ile Gly Phe Pro Gly Pro Lys Gly Val Pro Gly 
    290                 295                 300                 


Phe Lys Gly Glu Lys Gly Glu Phe Gly Ala Asp Gly Arg Lys Gly Ala 
305                 310                 315                 320 


Pro Gly Leu Ala Gly Lys Asn Gly Thr Asp Gly Gln Lys Gly Lys Leu 
                325                 330                 335     


Gly Arg Ile Gly Pro Pro Gly Cys Lys Gly Asp Pro Gly Asn Arg Gly 
            340                 345                 350         


Pro Asp Gly Tyr Pro Gly Glu Ala Gly Ser Pro Gly Glu Arg Gly Asp 
        355                 360                 365             


Gln Gly Gly Lys Gly Asp Pro Gly Arg Pro Gly Arg Arg Gly Pro Pro 
    370                 375                 380                 


Gly Glu Ile Gly Ala Lys Gly Ser Lys Gly Tyr Gln Gly Asn Ser Gly 
385                 390                 395                 400 


Ala Pro Gly Ser Pro Gly Val Lys Gly Ala Lys Gly Gly Pro Gly Pro 
                405                 410                 415     


Arg Gly Pro Lys Gly Glu Pro Gly Arg Arg Gly Asp Pro Gly Thr Lys 
            420                 425                 430         


Gly Ser Pro Gly Ser Asp Gly Pro Lys Gly Glu Lys Gly Asp Pro Gly 
        435                 440                 445             


Pro Glu Gly Pro Arg Gly Leu Ala Gly Glu Val Gly Asn Lys Gly Ala 
    450                 455                 460                 


Lys Gly Asp Arg Gly Leu Pro Gly Pro Arg Gly Pro Gln Gly Ala Leu 
465                 470                 475                 480 


Gly Glu Pro Gly Lys Gln Gly Ser Arg Gly Asp Pro Gly Asp Ala Gly 
                485                 490                 495     


Pro Arg Gly Asp Ser Gly Gln Pro Gly Pro Lys Gly Asp Pro Gly Arg 
            500                 505                 510         


Pro Gly Phe Ser Tyr Pro Gly Pro Arg Gly Ala Pro Gly Glu Lys Gly 
        515                 520                 525             


Glu Pro Gly Pro Arg Gly Pro Glu Gly Gly Arg Gly Asp Phe Gly Leu 
    530                 535                 540                 


Lys Gly Glu Pro Gly Arg Lys Gly Glu Lys Gly Glu Pro Ala Asp Pro 
545                 550                 555                 560 


Gly Pro Pro Gly Glu Pro Gly Pro Arg Gly Pro Arg Gly Val Pro Gly 
                565                 570                 575     


Pro Glu Gly Glu Pro Gly Pro Pro Gly Asp Pro Gly Leu Thr Glu Cys 
            580                 585                 590         


Asp Val Met Thr Tyr Val Arg Glu Thr Cys Gly Cys Cys Asp Cys Glu 
        595                 600                 605             


Lys Arg Cys Gly Ala Leu Asp Val Val Phe Val Ile Asp Ser Ser Glu 
    610                 615                 620                 


Ser Ile Gly Tyr Thr Asn Phe Thr Leu Glu Lys Asn Phe Val Ile Asn 
625                 630                 635                 640 


Val Val Asn Arg Leu Gly Ala Ile Ala Lys Asp Pro Lys Ser Glu Thr 
                645                 650                 655     


Gly Thr Arg Val Gly Val Val Gln Tyr Ser His Glu Gly Thr Phe Glu 
            660                 665                 670         


Ala Ile Gln Leu Asp Asp Glu Arg Ile Asp Ser Leu Ser Ser Phe Lys 
        675                 680                 685             


Glu Ala Val Lys Asn Leu Glu Trp Ile Ala Gly Gly Thr Trp Thr Pro 
    690                 695                 700                 


Ser Ala Leu Lys Phe Ala Tyr Asp Arg Leu Ile Lys Glu Ser Arg Arg 
705                 710                 715                 720 


Gln Lys Thr Arg Val Phe Ala Val Val Ile Thr Asp Gly Arg His Asp 
                725                 730                 735     


Pro Arg Asp Asp Asp Leu Asn Leu Arg Ala Leu Cys Asp Arg Asp Val 
            740                 745                 750         


Thr Val Thr Ala Ile Gly Ile Gly Asp Met Phe His Glu Lys His Glu 
        755                 760                 765             


Ser Glu Asn Leu Tyr Ser Ile Ala Cys Asp Lys Pro Gln Gln Val Arg 
    770                 775                 780                 


Asn Met Thr Leu Phe Ser Asp Leu Val Ala Glu Lys Phe Ile Asp Asp 
785                 790                 795                 800 


Met Glu Asp Val Leu Cys Pro Asp Pro Gln Ile Val Cys Pro Asp Leu 
                805                 810                 815     


Pro Cys Gln Thr Asp Ala Pro Trp Pro Gly Gly Glu Pro Pro Val Thr 
            820                 825                 830         


Phe Leu Arg Thr Glu Glu Gly Pro Asp Ala Thr Phe Pro Arg Thr Ile 
        835                 840                 845             


Pro Leu Ile Gln Gln Leu Leu Asn Ala Thr Glu Leu Thr Gln Asp Pro 
    850                 855                 860                 


Ala Ala Tyr Ser Gln Leu Val Ala Val Leu Val Tyr Thr Ala Glu Arg 
865                 870                 875                 880 


Ala Lys Phe Ala Thr Gly Val Glu Arg Gln Asp Trp Met Glu Leu Phe 
                885                 890                 895     


Ile Asp Thr Phe Lys Leu Val His Arg Asp Ile Val Gly Asp Pro Glu 
            900                 905                 910         


Thr Ala Leu Ala Leu Cys 
        915             


<210>  3328
<211>  828
<212>  PRT
<213>  Homo Sapiens

<400>  3328

Met Leu Gln Gly Thr Cys Ser Val Leu Leu Leu Trp Gly Ile Leu Gly 
1               5                   10                  15      


Ala Ile Gln Ala Gln Gln Gln Glu Val Ile Ser Pro Asp Thr Thr Glu 
            20                  25                  30          


Arg Asn Asn Asn Cys Pro Glu Lys Thr Asp Cys Pro Ile His Val Tyr 
        35                  40                  45              


Phe Val Leu Asp Thr Ser Glu Ser Val Thr Met Gln Ser Pro Thr Asp 
    50                  55                  60                  


Ile Leu Leu Phe His Met Lys Gln Phe Val Pro Gln Phe Ile Ser Gln 
65                  70                  75                  80  


Leu Gln Asn Glu Phe Tyr Leu Asp Gln Val Ala Leu Ser Trp Arg Tyr 
                85                  90                  95      


Gly Gly Leu His Phe Ser Asp Gln Val Glu Val Phe Ser Pro Pro Gly 
            100                 105                 110         


Ser Asp Arg Ala Ser Phe Ile Lys Asn Leu Gln Gly Ile Ser Ser Phe 
        115                 120                 125             


Arg Arg Gly Thr Phe Thr Asp Cys Ala Leu Ala Asn Met Thr Glu Gln 
    130                 135                 140                 


Ile Arg Gln Asp Arg Ser Lys Gly Thr Val His Phe Ala Val Val Ile 
145                 150                 155                 160 


Thr Asp Gly His Val Thr Gly Ser Pro Cys Gly Gly Ile Lys Leu Gln 
                165                 170                 175     


Ala Glu Arg Ala Arg Glu Glu Gly Ile Arg Leu Phe Ala Val Ala Pro 
            180                 185                 190         


Asn Gln Asn Leu Lys Glu Gln Gly Leu Arg Asp Ile Ala Ser Thr Pro 
        195                 200                 205             


His Glu Leu Tyr Arg Asn Asp Tyr Ala Thr Met Leu Pro Asp Ser Thr 
    210                 215                 220                 


Glu Ile Asp Gln Asp Thr Ile Asn Arg Ile Ile Lys Val Met Lys His 
225                 230                 235                 240 


Glu Ala Tyr Gly Glu Cys Tyr Lys Val Ser Cys Leu Glu Ile Pro Gly 
                245                 250                 255     


Pro Ser Gly Pro Lys Gly Tyr Arg Gly Gln Lys Gly Ala Lys Gly Asn 
            260                 265                 270         


Met Gly Glu Pro Gly Glu Pro Gly Gln Lys Gly Arg Gln Gly Asp Pro 
        275                 280                 285             


Gly Ile Glu Gly Pro Ile Gly Phe Pro Gly Pro Lys Gly Val Pro Gly 
    290                 295                 300                 


Phe Lys Gly Glu Lys Gly Glu Phe Gly Ala Asp Gly Arg Lys Gly Ala 
305                 310                 315                 320 


Pro Gly Leu Ala Gly Lys Asn Gly Thr Asp Gly Gln Lys Gly Lys Leu 
                325                 330                 335     


Gly Arg Ile Gly Pro Pro Gly Cys Lys Gly Asp Pro Gly Asn Arg Gly 
            340                 345                 350         


Pro Asp Gly Tyr Pro Gly Glu Ala Gly Ser Pro Gly Glu Arg Gly Asp 
        355                 360                 365             


Gln Gly Gly Lys Gly Asp Pro Gly Arg Pro Gly Arg Arg Gly Pro Pro 
    370                 375                 380                 


Gly Glu Ile Gly Ala Lys Gly Ser Lys Gly Tyr Gln Gly Asn Ser Gly 
385                 390                 395                 400 


Ala Pro Gly Ser Pro Gly Val Lys Gly Ala Lys Gly Gly Pro Gly Pro 
                405                 410                 415     


Arg Gly Pro Lys Gly Glu Pro Gly Arg Arg Gly Asp Pro Gly Thr Lys 
            420                 425                 430         


Gly Ser Pro Gly Ser Asp Gly Pro Lys Gly Glu Lys Gly Asp Pro Gly 
        435                 440                 445             


Pro Glu Gly Pro Arg Gly Leu Ala Gly Glu Val Gly Asn Lys Gly Ala 
    450                 455                 460                 


Lys Gly Asp Arg Gly Leu Pro Gly Pro Arg Gly Pro Gln Gly Ala Leu 
465                 470                 475                 480 


Gly Glu Pro Gly Lys Gln Gly Ser Arg Gly Asp Pro Gly Asp Ala Gly 
                485                 490                 495     


Pro Arg Gly Asp Ser Gly Gln Pro Gly Pro Lys Gly Asp Pro Gly Arg 
            500                 505                 510         


Pro Gly Phe Ser Tyr Pro Gly Pro Arg Gly Ala Pro Gly Glu Lys Gly 
        515                 520                 525             


Glu Pro Gly Pro Arg Gly Pro Glu Gly Gly Arg Gly Asp Phe Gly Leu 
    530                 535                 540                 


Lys Gly Glu Pro Gly Arg Lys Gly Glu Lys Gly Glu Pro Ala Asp Pro 
545                 550                 555                 560 


Gly Pro Pro Gly Glu Pro Gly Pro Arg Gly Pro Arg Gly Val Pro Gly 
                565                 570                 575     


Pro Glu Gly Glu Pro Gly Pro Pro Gly Asp Pro Gly Leu Thr Glu Cys 
            580                 585                 590         


Asp Val Met Thr Tyr Val Arg Glu Thr Cys Gly Cys Cys Asp Cys Glu 
        595                 600                 605             


Lys Arg Cys Gly Ala Leu Asp Val Val Phe Val Ile Asp Ser Ser Glu 
    610                 615                 620                 


Ser Ile Gly Tyr Thr Asn Phe Thr Leu Glu Lys Asn Phe Val Ile Asn 
625                 630                 635                 640 


Val Val Asn Arg Leu Gly Ala Ile Ala Lys Asp Pro Lys Ser Glu Thr 
                645                 650                 655     


Gly Thr Arg Val Gly Val Val Gln Tyr Ser His Glu Gly Thr Phe Glu 
            660                 665                 670         


Ala Ile Gln Leu Asp Asp Glu Arg Ile Asp Ser Leu Ser Ser Phe Lys 
        675                 680                 685             


Glu Ala Val Lys Asn Leu Glu Trp Ile Ala Gly Gly Thr Trp Thr Pro 
    690                 695                 700                 


Ser Ala Leu Lys Phe Ala Tyr Asp Arg Leu Ile Lys Glu Ser Arg Arg 
705                 710                 715                 720 


Gln Lys Thr Arg Val Phe Ala Val Val Ile Thr Asp Gly Arg His Asp 
                725                 730                 735     


Pro Arg Asp Asp Asp Leu Asn Leu Arg Ala Leu Cys Asp Arg Asp Val 
            740                 745                 750         


Thr Val Thr Ala Ile Gly Ile Gly Asp Met Phe His Glu Lys His Glu 
        755                 760                 765             


Ser Glu Asn Leu Tyr Ser Ile Ala Cys Asp Lys Pro Gln Gln Val Arg 
    770                 775                 780                 


Asn Met Thr Leu Phe Ser Asp Leu Val Ala Glu Lys Phe Ile Asp Asp 
785                 790                 795                 800 


Met Glu Asp Val Leu Cys Pro Asp Pro Gln Ile Val Cys Pro Asp Leu 
                805                 810                 815     


Pro Cys Gln Thr Gly Leu Asp Gly Ala Val Leu Cys 
            820                 825             


<210>  3329
<211>  2971
<212>  PRT
<213>  Homo Sapiens

<400>  3329

Met Arg Lys His Arg His Leu Pro Leu Val Ala Val Phe Cys Leu Phe 
1               5                   10                  15      


Leu Ser Gly Phe Pro Thr Thr His Ala Gln Gln Gln Gln Ala Ala Gln 
            20                  25                  30          


Asp Ser Ala Asp Ile Ile Phe Leu Ile Asp Gly Ser Asn Asn Thr Gly 
        35                  40                  45              


Ser Val Asn Phe Ala Val Ile Leu Asp Phe Leu Val Asn Leu Leu Glu 
    50                  55                  60                  


Lys Leu Pro Ile Gly Thr Gln Gln Ile Arg Val Gly Val Val Gln Phe 
65                  70                  75                  80  


Ser Asp Glu Pro Arg Thr Met Phe Ser Leu Asp Thr Tyr Ser Thr Lys 
                85                  90                  95      


Ala Gln Val Leu Gly Ala Val Lys Ala Leu Gly Phe Ala Gly Gly Glu 
            100                 105                 110         


Leu Ala Asn Ile Gly Leu Ala Leu Asp Phe Val Val Glu Asn His Phe 
        115                 120                 125             


Thr Arg Ala Gly Gly Ser Arg Val Glu Glu Gly Val Pro Gln Val Leu 
    130                 135                 140                 


Val Leu Ile Ser Ala Gly Pro Ser Ser Asp Glu Ile Arg Tyr Gly Val 
145                 150                 155                 160 


Val Ala Leu Lys Gln Ala Ser Val Phe Ser Phe Gly Leu Gly Ala Gln 
                165                 170                 175     


Ala Ala Ser Arg Ala Glu Leu Gln His Ile Ala Thr Asp Asp Asn Leu 
            180                 185                 190         


Val Phe Thr Val Pro Glu Phe Arg Ser Phe Gly Asp Leu Gln Glu Lys 
        195                 200                 205             


Leu Leu Pro Tyr Ile Val Gly Val Ala Gln Arg His Ile Val Leu Lys 
    210                 215                 220                 


Pro Pro Thr Ile Val Thr Gln Val Ile Glu Val Asn Lys Arg Asp Ile 
225                 230                 235                 240 


Val Phe Leu Val Asp Gly Ser Ser Ala Leu Gly Leu Ala Asn Phe Asn 
                245                 250                 255     


Ala Ile Arg Asp Phe Ile Ala Lys Val Ile Gln Arg Leu Glu Ile Gly 
            260                 265                 270         


Gln Asp Leu Ile Gln Val Ala Val Ala Gln Tyr Ala Asp Thr Val Arg 
        275                 280                 285             


Pro Glu Phe Tyr Phe Asn Thr His Pro Thr Lys Arg Glu Val Ile Thr 
    290                 295                 300                 


Ala Val Arg Lys Met Lys Pro Leu Asp Gly Ser Ala Leu Tyr Thr Gly 
305                 310                 315                 320 


Ser Ala Leu Asp Phe Val Arg Asn Asn Leu Phe Thr Ser Ser Ala Gly 
                325                 330                 335     


Tyr Arg Ala Ala Glu Gly Ile Pro Lys Leu Leu Val Leu Ile Thr Gly 
            340                 345                 350         


Gly Lys Ser Leu Asp Glu Ile Ser Gln Pro Ala Gln Glu Leu Lys Arg 
        355                 360                 365             


Ser Ser Ile Met Ala Phe Ala Ile Gly Asn Lys Gly Ala Asp Gln Ala 
    370                 375                 380                 


Glu Leu Glu Glu Ile Ala Phe Asp Ser Ser Leu Val Phe Ile Pro Ala 
385                 390                 395                 400 


Glu Phe Arg Ala Ala Pro Leu Gln Gly Met Leu Pro Gly Leu Leu Ala 
                405                 410                 415     


Pro Leu Arg Thr Leu Ser Gly Thr Pro Glu Val His Ser Asn Lys Arg 
            420                 425                 430         


Asp Ile Ile Phe Leu Leu Asp Gly Ser Ala Asn Val Gly Lys Thr Asn 
        435                 440                 445             


Phe Pro Tyr Val Arg Asp Phe Val Met Asn Leu Val Asn Ser Leu Asp 
    450                 455                 460                 


Ile Gly Asn Asp Asn Ile Arg Val Gly Leu Val Gln Phe Ser Asp Thr 
465                 470                 475                 480 


Pro Val Thr Glu Phe Ser Leu Asn Thr Tyr Gln Thr Lys Ser Asp Ile 
                485                 490                 495     


Leu Gly His Leu Arg Gln Leu Gln Leu Gln Gly Gly Ser Gly Leu Asn 
            500                 505                 510         


Thr Gly Ser Ala Leu Ser Tyr Val Tyr Ala Asn His Phe Thr Glu Ala 
        515                 520                 525             


Gly Gly Ser Arg Ile Arg Glu His Val Pro Gln Leu Leu Leu Leu Leu 
    530                 535                 540                 


Thr Ala Gly Gln Ser Glu Asp Ser Tyr Leu Gln Ala Ala Asn Ala Leu 
545                 550                 555                 560 


Thr Arg Ala Gly Ile Leu Thr Phe Cys Val Gly Ala Ser Gln Ala Asn 
                565                 570                 575     


Lys Ala Glu Leu Glu Gln Ile Ala Phe Asn Pro Ser Leu Val Tyr Leu 
            580                 585                 590         


Met Asp Asp Phe Ser Ser Leu Pro Ala Leu Pro Gln Gln Leu Ile Gln 
        595                 600                 605             


Pro Leu Thr Thr Tyr Val Ser Gly Gly Val Glu Glu Val Pro Leu Ala 
    610                 615                 620                 


Gln Pro Glu Ser Lys Arg Asp Ile Leu Phe Leu Phe Asp Gly Ser Ala 
625                 630                 635                 640 


Asn Leu Val Gly Gln Phe Pro Val Val Arg Asp Phe Leu Tyr Lys Ile 
                645                 650                 655     


Ile Asp Glu Leu Asn Val Lys Pro Glu Gly Thr Arg Ile Ala Val Ala 
            660                 665                 670         


Gln Tyr Ser Asp Asp Val Lys Val Glu Ser Arg Phe Asp Glu His Gln 
        675                 680                 685             


Ser Lys Pro Glu Ile Leu Asn Leu Val Lys Arg Met Lys Ile Lys Thr 
    690                 695                 700                 


Gly Lys Ala Leu Asn Leu Gly Tyr Ala Leu Asp Tyr Ala Gln Arg Tyr 
705                 710                 715                 720 


Ile Phe Val Lys Ser Ala Gly Ser Arg Ile Glu Asp Gly Val Leu Gln 
                725                 730                 735     


Phe Leu Val Leu Leu Val Ala Gly Arg Ser Ser Asp Arg Val Asp Gly 
            740                 745                 750         


Pro Ala Ser Asn Leu Lys Gln Ser Gly Val Val Pro Phe Ile Phe Gln 
        755                 760                 765             


Ala Lys Asn Ala Asp Pro Ala Glu Leu Glu Gln Ile Val Leu Ser Pro 
    770                 775                 780                 


Ala Phe Ile Leu Ala Ala Glu Ser Leu Pro Lys Ile Gly Asp Leu His 
785                 790                 795                 800 


Pro Gln Ile Val Asn Leu Leu Lys Ser Val His Asn Gly Ala Pro Ala 
                805                 810                 815     


Pro Val Ser Gly Glu Lys Asp Val Val Phe Leu Leu Asp Gly Ser Glu 
            820                 825                 830         


Gly Val Arg Ser Gly Phe Pro Leu Leu Lys Glu Phe Val Gln Arg Val 
        835                 840                 845             


Val Glu Ser Leu Asp Val Gly Gln Asp Arg Val Arg Val Ala Val Val 
    850                 855                 860                 


Gln Tyr Ser Asp Arg Thr Arg Pro Glu Phe Tyr Leu Asn Ser Tyr Met 
865                 870                 875                 880 


Asn Lys Gln Asp Val Val Asn Ala Val Arg Gln Leu Thr Leu Leu Gly 
                885                 890                 895     


Gly Pro Thr Pro Asn Thr Gly Ala Ala Leu Glu Phe Val Leu Arg Asn 
            900                 905                 910         


Ile Leu Val Ser Ser Ala Gly Ser Arg Ile Thr Glu Gly Val Pro Gln 
        915                 920                 925             


Leu Leu Ile Val Leu Thr Ala Asp Arg Ser Gly Asp Asp Val Arg Asn 
    930                 935                 940                 


Pro Ser Val Val Val Lys Arg Gly Gly Ala Val Pro Ile Gly Ile Gly 
945                 950                 955                 960 


Ile Gly Asn Ala Asp Ile Thr Glu Met Gln Thr Ile Ser Phe Ile Pro 
                965                 970                 975     


Asp Phe Ala Val Ala Ile Pro Thr Phe Arg Gln Leu Gly Thr Val Gln 
            980                 985                 990         


Gln Val Ile Ser Glu Arg Val Thr  Gln Leu Thr Arg Glu  Glu Leu Ser 
        995                 1000                 1005             


Arg Leu  Gln Pro Val Leu Gln  Pro Leu Pro Ser Pro  Gly Val Gly 
    1010                 1015                 1020             


Gly Lys  Arg Asp Val Val Phe  Leu Ile Asp Gly Ser  Gln Ser Ala 
    1025                 1030                 1035             


Gly Pro  Glu Phe Gln Tyr Val  Arg Thr Leu Ile Glu  Arg Leu Val 
    1040                 1045                 1050             


Asp Tyr  Leu Asp Val Gly Phe  Asp Thr Thr Arg Val  Ala Val Ile 
    1055                 1060                 1065             


Gln Phe  Ser Asp Asp Pro Lys  Val Glu Phe Leu Leu  Asn Ala His 
    1070                 1075                 1080             


Ser Ser  Lys Asp Glu Val Gln  Asn Ala Val Gln Arg  Leu Arg Pro 
    1085                 1090                 1095             


Lys Gly  Gly Arg Gln Ile Asn  Val Gly Asn Ala Leu  Glu Tyr Val 
    1100                 1105                 1110             


Ser Arg  Asn Ile Phe Lys Arg  Pro Leu Gly Ser Arg  Ile Glu Glu 
    1115                 1120                 1125             


Gly Val  Pro Gln Phe Leu Val  Leu Ile Ser Ser Gly  Lys Ser Asp 
    1130                 1135                 1140             


Asp Glu  Val Asp Asp Pro Ala  Val Glu Leu Lys Gln  Phe Gly Val 
    1145                 1150                 1155             


Ala Pro  Phe Thr Ile Ala Arg  Asn Ala Asp Gln Glu  Glu Leu Val 
    1160                 1165                 1170             


Lys Ile  Ser Leu Ser Pro Glu  Tyr Val Phe Ser Val  Ser Thr Phe 
    1175                 1180                 1185             


Arg Glu  Leu Pro Ser Leu Glu  Gln Lys Leu Leu Thr  Pro Ile Thr 
    1190                 1195                 1200             


Thr Leu  Thr Ser Glu Gln Ile  Gln Lys Leu Leu Ala  Ser Thr Arg 
    1205                 1210                 1215             


Tyr Pro  Pro Pro Ala Val Glu  Ser Asp Ala Ala Asp  Ile Val Phe 
    1220                 1225                 1230             


Leu Ile  Asp Ser Ser Glu Gly  Val Arg Pro Asp Gly  Phe Ala His 
    1235                 1240                 1245             


Ile Arg  Asp Phe Val Ser Arg  Ile Val Arg Arg Leu  Asn Ile Gly 
    1250                 1255                 1260             


Pro Ser  Lys Val Arg Val Gly  Val Val Gln Phe Ser  Asn Asp Val 
    1265                 1270                 1275             


Phe Pro  Glu Phe Tyr Leu Lys  Thr Tyr Arg Ser Gln  Ala Pro Val 
    1280                 1285                 1290             


Leu Asp  Ala Ile Arg Arg Leu  Arg Leu Arg Gly Gly  Ser Pro Leu 
    1295                 1300                 1305             


Asn Thr  Gly Lys Ala Leu Glu  Phe Val Ala Arg Asn  Leu Phe Val 
    1310                 1315                 1320             


Lys Ser  Ala Gly Ser Arg Ile  Glu Asp Gly Val Pro  Gln His Leu 
    1325                 1330                 1335             


Val Leu  Val Leu Gly Gly Lys  Ser Gln Asp Asp Val  Ser Arg Phe 
    1340                 1345                 1350             


Ala Gln  Val Ile Arg Ser Ser  Gly Ile Val Ser Leu  Gly Val Gly 
    1355                 1360                 1365             


Asp Arg  Asn Ile Asp Arg Thr  Glu Leu Gln Thr Ile  Thr Asn Asp 
    1370                 1375                 1380             


Pro Arg  Leu Val Phe Thr Val  Arg Glu Phe Arg Glu  Leu Pro Asn 
    1385                 1390                 1395             


Ile Glu  Glu Arg Ile Met Asn  Ser Phe Gly Pro Ser  Ala Ala Thr 
    1400                 1405                 1410             


Pro Ala  Pro Pro Gly Val Asp  Thr Pro Pro Pro Ser  Arg Pro Glu 
    1415                 1420                 1425             


Lys Lys  Lys Ala Asp Ile Val  Phe Leu Leu Asp Gly  Ser Ile Asn 
    1430                 1435                 1440             


Phe Arg  Arg Asp Ser Phe Gln  Glu Val Leu Arg Phe  Val Ser Glu 
    1445                 1450                 1455             


Ile Val  Asp Thr Val Tyr Glu  Asp Gly Asp Ser Ile  Gln Val Gly 
    1460                 1465                 1470             


Leu Val  Gln Tyr Asn Ser Asp  Pro Thr Asp Glu Phe  Phe Leu Lys 
    1475                 1480                 1485             


Asp Phe  Ser Thr Lys Arg Gln  Ile Ile Asp Ala Ile  Asn Lys Val 
    1490                 1495                 1500             


Val Tyr  Lys Gly Gly Arg His  Ala Asn Thr Lys Val  Gly Leu Glu 
    1505                 1510                 1515             


His Leu  Arg Val Asn His Phe  Val Pro Glu Ala Gly  Ser Arg Leu 
    1520                 1525                 1530             


Asp Gln  Arg Val Pro Gln Ile  Ala Phe Val Ile Thr  Gly Gly Lys 
    1535                 1540                 1545             


Ser Val  Glu Asp Ala Gln Asp  Val Ser Leu Ala Leu  Thr Gln Arg 
    1550                 1555                 1560             


Gly Val  Lys Val Phe Ala Val  Gly Val Arg Asn Ile  Asp Ser Glu 
    1565                 1570                 1575             


Glu Val  Gly Lys Ile Ala Ser  Asn Ser Ala Thr Ala  Phe Arg Val 
    1580                 1585                 1590             


Gly Asn  Val Gln Glu Leu Ser  Glu Leu Ser Glu Gln  Val Leu Glu 
    1595                 1600                 1605             


Thr Leu  His Asp Ala Met His  Glu Thr Leu Cys Pro  Gly Val Thr 
    1610                 1615                 1620             


Asp Ala  Ala Lys Ala Cys Asn  Leu Asp Val Ile Leu  Gly Phe Asp 
    1625                 1630                 1635             


Gly Ser  Arg Asp Gln Asn Val  Phe Val Ala Gln Lys  Gly Phe Glu 
    1640                 1645                 1650             


Ser Lys  Val Asp Ala Ile Leu  Asn Arg Ile Ser Gln  Met His Arg 
    1655                 1660                 1665             


Val Ser  Cys Ser Gly Gly Arg  Ser Pro Thr Val Arg  Val Ser Val 
    1670                 1675                 1680             


Val Ala  Asn Thr Pro Ser Gly  Pro Val Glu Ala Phe  Asp Phe Asp 
    1685                 1690                 1695             


Glu Tyr  Gln Pro Glu Met Leu  Glu Lys Phe Arg Asn  Met Arg Ser 
    1700                 1705                 1710             


Gln His  Pro Tyr Val Leu Thr  Glu Asp Thr Leu Lys  Val Tyr Leu 
    1715                 1720                 1725             


Asn Lys  Phe Arg Gln Ser Ser  Pro Asp Ser Val Lys  Val Val Ile 
    1730                 1735                 1740             


His Phe  Thr Asp Gly Ala Asp  Gly Asp Leu Ala Asp  Leu His Arg 
    1745                 1750                 1755             


Ala Ser  Glu Asn Leu Arg Gln  Glu Gly Val Arg Ala  Leu Ile Leu 
    1760                 1765                 1770             


Val Gly  Leu Glu Arg Val Val  Asn Leu Glu Arg Leu  Met His Leu 
    1775                 1780                 1785             


Glu Phe  Gly Arg Gly Phe Met  Tyr Asp Arg Pro Leu  Arg Leu Asn 
    1790                 1795                 1800             


Leu Leu  Asp Leu Asp Tyr Glu  Leu Ala Glu Gln Leu  Asp Asn Ile 
    1805                 1810                 1815             


Ala Glu  Lys Ala Cys Cys Gly  Val Pro Cys Lys Cys  Ser Gly Gln 
    1820                 1825                 1830             


Arg Gly  Asp Arg Gly Pro Ile  Gly Ser Ile Gly Pro  Lys Gly Ile 
    1835                 1840                 1845             


Pro Gly  Glu Asp Gly Tyr Arg  Gly Tyr Pro Gly Asp  Glu Gly Gly 
    1850                 1855                 1860             


Pro Gly  Glu Arg Gly Pro Pro  Gly Val Asn Gly Thr  Gln Gly Phe 
    1865                 1870                 1875             


Gln Gly  Cys Pro Gly Gln Arg  Gly Val Lys Gly Ser  Arg Gly Phe 
    1880                 1885                 1890             


Pro Gly  Glu Lys Gly Glu Val  Gly Glu Ile Gly Leu  Asp Gly Leu 
    1895                 1900                 1905             


Asp Gly  Glu Asp Gly Asp Lys  Gly Leu Pro Gly Ser  Ser Gly Glu 
    1910                 1915                 1920             


Lys Gly  Asn Pro Gly Arg Arg  Gly Asp Lys Gly Pro  Arg Gly Glu 
    1925                 1930                 1935             


Lys Gly  Glu Arg Gly Asp Val  Gly Ile Arg Gly Asp  Pro Gly Asn 
    1940                 1945                 1950             


Pro Gly  Gln Asp Ser Gln Glu  Arg Gly Pro Lys Gly  Glu Thr Gly 
    1955                 1960                 1965             


Asp Leu  Gly Pro Met Gly Val  Pro Gly Arg Asp Gly  Val Pro Gly 
    1970                 1975                 1980             


Gly Pro  Gly Glu Thr Gly Lys  Asn Gly Gly Phe Gly  Arg Arg Gly 
    1985                 1990                 1995             


Pro Pro  Gly Ala Lys Gly Asn  Lys Gly Gly Pro Gly  Gln Pro Gly 
    2000                 2005                 2010             


Phe Glu  Gly Glu Gln Gly Thr  Arg Gly Ala Gln Gly  Pro Ala Gly 
    2015                 2020                 2025             


Pro Ala  Gly Pro Pro Gly Leu  Ile Gly Glu Gln Gly  Ile Ser Gly 
    2030                 2035                 2040             


Pro Arg  Gly Ser Gly Gly Ala  Ala Gly Ala Pro Gly  Glu Arg Gly 
    2045                 2050                 2055             


Arg Thr  Gly Pro Leu Gly Arg  Lys Gly Glu Pro Gly  Glu Pro Gly 
    2060                 2065                 2070             


Pro Lys  Gly Gly Ile Gly Asn  Arg Gly Pro Arg Gly  Glu Thr Gly 
    2075                 2080                 2085             


Asp Asp  Gly Arg Asp Gly Val  Gly Ser Glu Gly Arg  Arg Gly Lys 
    2090                 2095                 2100             


Lys Gly  Glu Arg Gly Phe Pro  Gly Tyr Pro Gly Pro  Lys Gly Asn 
    2105                 2110                 2115             


Pro Gly  Glu Pro Gly Leu Asn  Gly Thr Thr Gly Pro  Lys Gly Ile 
    2120                 2125                 2130             


Arg Gly  Arg Arg Gly Asn Ser  Gly Pro Pro Gly Ile  Val Gly Gln 
    2135                 2140                 2145             


Lys Gly  Asp Pro Gly Tyr Pro  Gly Pro Ala Gly Pro  Lys Gly Asn 
    2150                 2155                 2160             


Arg Gly  Asp Ser Ile Asp Gln  Cys Ala Leu Ile Gln  Ser Ile Lys 
    2165                 2170                 2175             


Asp Lys  Cys Pro Cys Cys Tyr  Gly Pro Leu Glu Cys  Pro Val Phe 
    2180                 2185                 2190             


Pro Thr  Glu Leu Ala Phe Ala  Leu Asp Thr Ser Glu  Gly Val Asn 
    2195                 2200                 2205             


Gln Asp  Thr Phe Gly Arg Met  Arg Asp Val Val Leu  Ser Ile Val 
    2210                 2215                 2220             


Asn Asp  Leu Thr Ile Ala Glu  Ser Asn Cys Pro Arg  Gly Ala Arg 
    2225                 2230                 2235             


Val Ala  Val Val Thr Tyr Asn  Asn Glu Val Thr Thr  Glu Ile Arg 
    2240                 2245                 2250             


Phe Ala  Asp Ser Lys Arg Lys  Ser Val Leu Leu Asp  Lys Ile Lys 
    2255                 2260                 2265             


Asn Leu  Gln Val Ala Leu Thr  Ser Lys Gln Gln Ser  Leu Glu Thr 
    2270                 2275                 2280             


Ala Met  Ser Phe Val Ala Arg  Asn Thr Phe Lys Arg  Val Arg Asn 
    2285                 2290                 2295             


Gly Phe  Leu Met Arg Lys Val  Ala Val Phe Phe Ser  Asn Thr Pro 
    2300                 2305                 2310             


Thr Arg  Ala Ser Pro Gln Leu  Arg Glu Ala Val Leu  Lys Leu Ser 
    2315                 2320                 2325             


Asp Ala  Gly Ile Thr Pro Leu  Phe Leu Thr Arg Gln  Glu Asp Arg 
    2330                 2335                 2340             


Gln Leu  Ile Asn Ala Leu Gln  Ile Asn Asn Thr Ala  Val Gly His 
    2345                 2350                 2355             


Ala Leu  Val Leu Pro Ala Gly  Arg Asp Leu Thr Asp  Phe Leu Glu 
    2360                 2365                 2370             


Asn Val  Leu Thr Cys His Val  Cys Leu Asp Ile Cys  Asn Ile Asp 
    2375                 2380                 2385             


Pro Ser  Cys Gly Phe Gly Ser  Trp Arg Pro Ser Phe  Arg Asp Arg 
    2390                 2395                 2400             


Arg Ala  Ala Gly Ser Asp Val  Asp Ile Asp Met Ala  Phe Ile Leu 
    2405                 2410                 2415             


Asp Ser  Ala Glu Thr Thr Thr  Leu Phe Gln Phe Asn  Glu Met Lys 
    2420                 2425                 2430             


Lys Tyr  Ile Ala Tyr Leu Val  Arg Gln Leu Asp Met  Ser Pro Asp 
    2435                 2440                 2445             


Pro Lys  Ala Ser Gln His Phe  Ala Arg Val Ala Val  Val Gln His 
    2450                 2455                 2460             


Ala Pro  Ser Glu Ser Val Asp  Asn Ala Ser Met Pro  Pro Val Lys 
    2465                 2470                 2475             


Val Glu  Phe Ser Leu Thr Asp  Tyr Gly Ser Lys Glu  Lys Leu Val 
    2480                 2485                 2490             


Asp Phe  Leu Ser Arg Gly Met  Thr Gln Leu Gln Gly  Thr Arg Ala 
    2495                 2500                 2505             


Leu Gly  Ser Ala Ile Glu Tyr  Thr Ile Glu Asn Val  Phe Glu Ser 
    2510                 2515                 2520             


Ala Pro  Asn Pro Arg Asp Leu  Lys Ile Val Val Leu  Met Leu Thr 
    2525                 2530                 2535             


Gly Glu  Val Pro Glu Gln Gln  Leu Glu Glu Ala Gln  Arg Val Ile 
    2540                 2545                 2550             


Leu Gln  Ala Lys Cys Lys Gly  Tyr Phe Phe Val Val  Leu Gly Ile 
    2555                 2560                 2565             


Gly Arg  Lys Val Asn Ile Lys  Glu Val Tyr Thr Phe  Ala Ser Glu 
    2570                 2575                 2580             


Pro Asn  Asp Val Phe Phe Lys  Leu Val Asp Lys Ser  Thr Glu Leu 
    2585                 2590                 2595             


Asn Glu  Glu Pro Leu Met Arg  Phe Gly Arg Leu Leu  Pro Ser Phe 
    2600                 2605                 2610             


Val Ser  Ser Glu Asn Ala Phe  Tyr Leu Ser Pro Asp  Ile Arg Lys 
    2615                 2620                 2625             


Gln Cys  Asp Trp Phe Gln Gly  Asp Gln Pro Thr Lys  Asn Leu Val 
    2630                 2635                 2640             


Lys Phe  Gly His Lys Gln Val  Asn Val Pro Asn Asn  Val Thr Ser 
    2645                 2650                 2655             


Ser Pro  Thr Ser Asn Pro Val  Thr Thr Thr Lys Pro  Val Thr Thr 
    2660                 2665                 2670             


Thr Lys  Pro Val Thr Thr Thr  Thr Lys Pro Val Thr  Thr Thr Thr 
    2675                 2680                 2685             


Lys Pro  Val Thr Ile Ile Asn  Gln Pro Ser Val Lys  Pro Ala Ala 
    2690                 2695                 2700             


Ala Lys  Pro Ala Pro Ala Lys  Pro Val Ala Ala Lys  Pro Val Ala 
    2705                 2710                 2715             


Thr Lys  Met Ala Thr Val Arg  Pro Pro Val Ala Val  Lys Pro Ala 
    2720                 2725                 2730             


Thr Ala  Ala Lys Pro Val Ala  Ala Lys Pro Ala Ala  Val Arg Pro 
    2735                 2740                 2745             


Pro Ala  Ala Ala Ala Ala Lys  Pro Val Ala Thr Lys  Pro Glu Val 
    2750                 2755                 2760             


Pro Arg  Pro Gln Ala Ala Lys  Pro Ala Ala Thr Lys  Pro Ala Thr 
    2765                 2770                 2775             


Thr Lys  Pro Met Val Lys Met  Ser Arg Glu Val Gln  Val Phe Glu 
    2780                 2785                 2790             


Ile Thr  Glu Asn Ser Ala Lys  Leu His Trp Glu Arg  Ala Glu Pro 
    2795                 2800                 2805             


Pro Gly  Pro Tyr Phe Tyr Asp  Leu Thr Val Thr Ser  Ala His Asp 
    2810                 2815                 2820             


Gln Ser  Leu Val Leu Lys Gln  Asn Leu Thr Val Thr  Asp Arg Val 
    2825                 2830                 2835             


Ile Gly  Gly Leu Leu Ala Gly  Gln Thr Tyr His Val  Ala Val Val 
    2840                 2845                 2850             


Cys Tyr  Leu Arg Ser Gln Val  Arg Ala Thr Tyr His  Gly Ser Phe 
    2855                 2860                 2865             


Ser Thr  Lys Lys Ser Gln Pro  Pro Pro Pro Gln Pro  Ala Arg Ser 
    2870                 2875                 2880             


Ala Ser  Ser Ser Thr Ile Asn  Leu Met Val Ser Thr  Glu Pro Leu 
    2885                 2890                 2895             


Ala Leu  Thr Glu Thr Asp Ile  Cys Lys Leu Pro Lys  Asp Glu Gly 
    2900                 2905                 2910             


Thr Cys  Arg Asp Phe Ile Leu  Lys Trp Tyr Tyr Asp  Pro Asn Thr 
    2915                 2920                 2925             


Lys Ser  Cys Ala Arg Phe Trp  Tyr Gly Gly Cys Gly  Gly Asn Glu 
    2930                 2935                 2940             


Asn Lys  Phe Gly Ser Gln Lys  Glu Cys Glu Lys Val  Cys Ala Pro 
    2945                 2950                 2955             


Val Leu  Ala Lys Pro Gly Val  Ile Ser Val Met Gly  Thr 
    2960                 2965                 2970     


<210>  3330
<211>  1237
<212>  PRT
<213>  Homo Sapiens

<400>  3330

Met Arg Lys His Arg His Leu Pro Leu Val Ala Val Phe Cys Leu Phe 
1               5                   10                  15      


Leu Ser Gly Phe Pro Thr Thr His Ala Gln Gln Gln Gln Ala Ala Gln 
            20                  25                  30          


Asp Ser Ala Asp Ile Ile Phe Leu Ile Asp Gly Ser Asn Asn Thr Gly 
        35                  40                  45              


Ser Val Asn Phe Ala Val Ile Leu Asp Phe Leu Val Asn Leu Leu Glu 
    50                  55                  60                  


Lys Leu Pro Ile Gly Thr Gln Gln Ile Arg Val Gly Val Val Gln Phe 
65                  70                  75                  80  


Ser Asp Glu Pro Arg Thr Met Phe Ser Leu Asp Thr Tyr Ser Thr Lys 
                85                  90                  95      


Ala Gln Val Leu Gly Ala Val Lys Ala Leu Gly Phe Ala Gly Gly Glu 
            100                 105                 110         


Leu Ala Asn Ile Gly Leu Ala Leu Asp Phe Val Val Glu Asn His Phe 
        115                 120                 125             


Thr Arg Ala Gly Gly Ser Arg Val Glu Glu Gly Val Pro Gln Val Leu 
    130                 135                 140                 


Val Leu Ile Ser Ala Gly Pro Ser Ser Asp Glu Ile Arg Tyr Gly Val 
145                 150                 155                 160 


Val Ala Leu Lys Gln Ala Ser Val Phe Ser Phe Gly Leu Gly Ala Gln 
                165                 170                 175     


Ala Ala Ser Arg Ala Glu Leu Gln His Ile Ala Thr Asp Asp Asn Leu 
            180                 185                 190         


Val Phe Thr Val Pro Glu Phe Arg Ser Phe Gly Asp Leu Gln Glu Lys 
        195                 200                 205             


Leu Leu Pro Tyr Ile Val Gly Val Ala Gln Arg His Ile Val Leu Lys 
    210                 215                 220                 


Pro Pro Thr Ile Val Thr Gln Val Ile Glu Val Asn Lys Arg Asp Ile 
225                 230                 235                 240 


Val Phe Leu Val Asp Gly Ser Ser Ala Leu Gly Leu Ala Asn Phe Asn 
                245                 250                 255     


Ala Ile Arg Asp Phe Ile Ala Lys Val Ile Gln Arg Leu Glu Ile Gly 
            260                 265                 270         


Gln Asp Leu Ile Gln Val Ala Val Ala Gln Tyr Ala Asp Thr Val Arg 
        275                 280                 285             


Pro Glu Phe Tyr Phe Asn Thr His Pro Thr Lys Arg Glu Val Ile Thr 
    290                 295                 300                 


Ala Val Arg Lys Met Lys Pro Leu Asp Gly Ser Ala Leu Tyr Thr Gly 
305                 310                 315                 320 


Ser Ala Leu Asp Phe Val Arg Asn Asn Leu Phe Thr Ser Ser Ala Gly 
                325                 330                 335     


Tyr Arg Ala Ala Glu Gly Ile Pro Lys Leu Leu Val Leu Ile Thr Gly 
            340                 345                 350         


Gly Lys Ser Leu Asp Glu Ile Ser Gln Pro Ala Gln Glu Leu Lys Arg 
        355                 360                 365             


Ser Ser Ile Met Ala Phe Ala Ile Gly Asn Lys Gly Ala Asp Gln Ala 
    370                 375                 380                 


Glu Leu Glu Glu Ile Ala Phe Asp Ser Ser Leu Val Phe Ile Pro Ala 
385                 390                 395                 400 


Glu Phe Arg Ala Ala Pro Leu Gln Gly Met Leu Pro Gly Leu Leu Ala 
                405                 410                 415     


Pro Leu Arg Thr Leu Ser Gly Thr Pro Glu Val His Ser Asn Lys Arg 
            420                 425                 430         


Asp Ile Ile Phe Leu Leu Asp Gly Ser Ala Asn Val Gly Lys Thr Asn 
        435                 440                 445             


Phe Pro Tyr Val Arg Asp Phe Val Met Asn Leu Val Asn Ser Leu Asp 
    450                 455                 460                 


Ile Gly Asn Asp Asn Ile Arg Val Gly Leu Val Gln Phe Ser Asp Thr 
465                 470                 475                 480 


Pro Val Thr Glu Phe Ser Leu Asn Thr Tyr Gln Thr Lys Ser Asp Ile 
                485                 490                 495     


Leu Gly His Leu Arg Gln Leu Gln Leu Gln Gly Gly Ser Gly Leu Asn 
            500                 505                 510         


Thr Gly Ser Ala Leu Ser Tyr Val Tyr Ala Asn His Phe Thr Glu Ala 
        515                 520                 525             


Gly Gly Ser Arg Ile Arg Glu His Val Pro Gln Leu Leu Leu Leu Leu 
    530                 535                 540                 


Thr Ala Gly Gln Ser Glu Asp Ser Tyr Leu Gln Ala Ala Asn Ala Leu 
545                 550                 555                 560 


Thr Arg Ala Gly Ile Leu Thr Phe Cys Val Gly Ala Ser Gln Ala Asn 
                565                 570                 575     


Lys Ala Glu Leu Glu Gln Ile Ala Phe Asn Pro Ser Leu Val Tyr Leu 
            580                 585                 590         


Met Asp Asp Phe Ser Ser Leu Pro Ala Leu Pro Gln Gln Leu Ile Gln 
        595                 600                 605             


Pro Leu Thr Thr Tyr Val Ser Gly Gly Val Glu Glu Val Pro Leu Ala 
    610                 615                 620                 


Gln Pro Glu Ser Lys Arg Asp Ile Leu Phe Leu Phe Asp Gly Ser Ala 
625                 630                 635                 640 


Asn Leu Val Gly Gln Phe Pro Val Val Arg Asp Phe Leu Tyr Lys Ile 
                645                 650                 655     


Ile Asp Glu Leu Asn Val Lys Pro Glu Gly Thr Arg Ile Ala Val Ala 
            660                 665                 670         


Gln Tyr Ser Asp Asp Val Lys Val Glu Ser Arg Phe Asp Glu His Gln 
        675                 680                 685             


Ser Lys Pro Glu Ile Leu Asn Leu Val Lys Arg Met Lys Ile Lys Thr 
    690                 695                 700                 


Gly Lys Ala Leu Asn Leu Gly Tyr Ala Leu Asp Tyr Ala Gln Arg Tyr 
705                 710                 715                 720 


Ile Phe Val Lys Ser Ala Gly Ser Arg Ile Glu Asp Gly Val Leu Gln 
                725                 730                 735     


Phe Leu Val Leu Leu Val Ala Gly Arg Ser Ser Asp Arg Val Asp Gly 
            740                 745                 750         


Pro Ala Ser Asn Leu Lys Gln Ser Gly Val Val Pro Phe Ile Phe Gln 
        755                 760                 765             


Ala Lys Asn Ala Asp Pro Ala Glu Leu Glu Gln Ile Val Leu Ser Pro 
    770                 775                 780                 


Ala Phe Ile Leu Ala Ala Glu Ser Leu Pro Lys Ile Gly Asp Leu His 
785                 790                 795                 800 


Pro Gln Ile Val Asn Leu Leu Lys Ser Val His Asn Gly Ala Pro Ala 
                805                 810                 815     


Pro Val Ser Gly Glu Lys Asp Val Val Phe Leu Leu Asp Gly Ser Glu 
            820                 825                 830         


Gly Val Arg Ser Gly Phe Pro Leu Leu Lys Glu Phe Val Gln Arg Val 
        835                 840                 845             


Val Glu Ser Leu Asp Val Gly Gln Asp Arg Val Arg Val Ala Val Val 
    850                 855                 860                 


Gln Tyr Ser Asp Arg Thr Arg Pro Glu Phe Tyr Leu Asn Ser Tyr Met 
865                 870                 875                 880 


Asn Lys Gln Asp Val Val Asn Ala Val Arg Gln Leu Thr Leu Leu Gly 
                885                 890                 895     


Gly Pro Thr Pro Asn Thr Gly Ala Ala Leu Glu Phe Val Leu Arg Asn 
            900                 905                 910         


Ile Leu Val Ser Ser Ala Gly Ser Arg Ile Thr Glu Gly Val Pro Gln 
        915                 920                 925             


Leu Leu Ile Val Leu Thr Ala Asp Arg Ser Gly Asp Asp Val Arg Asn 
    930                 935                 940                 


Pro Ser Val Val Val Lys Arg Gly Gly Ala Val Pro Ile Gly Ile Gly 
945                 950                 955                 960 


Ile Gly Asn Ala Asp Ile Thr Glu Met Gln Thr Ile Ser Phe Ile Pro 
                965                 970                 975     


Asp Phe Ala Val Ala Ile Pro Thr Phe Arg Gln Leu Gly Thr Val Gln 
            980                 985                 990         


Gln Val Ile Ser Glu Arg Val Thr  Gln Leu Thr Arg Glu  Glu Leu Ser 
        995                 1000                 1005             


Arg Leu  Gln Pro Val Leu Gln  Pro Leu Pro Ser Pro  Gly Val Gly 
    1010                 1015                 1020             


Gly Lys  Arg Asp Val Val Phe  Leu Ile Asp Gly Ser  Gln Ser Ala 
    1025                 1030                 1035             


Gly Pro  Glu Phe Gln Tyr Val  Arg Thr Leu Ile Glu  Arg Leu Val 
    1040                 1045                 1050             


Asp Tyr  Leu Asp Val Gly Phe  Asp Thr Thr Arg Val  Ala Val Ile 
    1055                 1060                 1065             


Gln Phe  Ser Asp Asp Pro Lys  Val Glu Phe Leu Leu  Asn Ala His 
    1070                 1075                 1080             


Ser Ser  Lys Asp Glu Val Gln  Asn Ala Val Gln Arg  Leu Arg Pro 
    1085                 1090                 1095             


Lys Gly  Gly Arg Gln Ile Asn  Val Gly Asn Ala Leu  Glu Tyr Val 
    1100                 1105                 1110             


Ser Arg  Asn Ile Phe Lys Arg  Pro Leu Gly Ser Arg  Ile Glu Glu 
    1115                 1120                 1125             


Gly Val  Pro Gln Phe Leu Val  Leu Ile Ser Ser Gly  Lys Ser Asp 
    1130                 1135                 1140             


Asp Glu  Val Asp Asp Pro Ala  Val Glu Leu Lys Gln  Phe Gly Val 
    1145                 1150                 1155             


Ala Pro  Phe Thr Ile Ala Arg  Asn Ala Asp Gln Glu  Glu Leu Val 
    1160                 1165                 1170             


Lys Ile  Ser Leu Ser Pro Glu  Tyr Val Phe Ser Val  Ser Thr Phe 
    1175                 1180                 1185             


Arg Glu  Leu Pro Ser Leu Glu  Gln Lys Leu Leu Thr  Pro Ile Thr 
    1190                 1195                 1200             


Thr Leu  Thr Ser Glu Gln Ile  Gln Lys Leu Leu Ala  Ser Thr Arg 
    1205                 1210                 1215             


Tyr Pro  Pro Pro Gly Glu Met  Gly Ala Ser Glu Val  Leu Leu Gly 
    1220                 1225                 1230             


Ala Phe  Ser Ile 
    1235         


<210>  3331
<211>  2971
<212>  PRT
<213>  Homo Sapiens

<400>  3331

Met Arg Lys His Arg His Leu Pro Leu Val Ala Val Phe Cys Leu Phe 
1               5                   10                  15      


Leu Ser Gly Phe Pro Thr Thr His Ala Gln Gln Gln Gln Ala Ala Gln 
            20                  25                  30          


Asp Ser Ala Asp Ile Ile Phe Leu Ile Asp Gly Ser Asn Asn Thr Gly 
        35                  40                  45              


Ser Val Asn Phe Ala Val Ile Leu Asp Phe Leu Val Asn Leu Leu Glu 
    50                  55                  60                  


Lys Leu Pro Ile Gly Thr Gln Gln Ile Arg Val Gly Val Val Gln Phe 
65                  70                  75                  80  


Ser Asp Glu Pro Arg Thr Met Phe Ser Leu Asp Thr Tyr Ser Thr Lys 
                85                  90                  95      


Ala Gln Val Leu Gly Ala Val Lys Ala Leu Gly Phe Ala Gly Gly Glu 
            100                 105                 110         


Leu Ala Asn Ile Gly Leu Ala Leu Asp Phe Val Val Glu Asn His Phe 
        115                 120                 125             


Thr Arg Ala Gly Gly Ser Arg Val Glu Glu Gly Val Pro Gln Val Leu 
    130                 135                 140                 


Val Leu Ile Ser Ala Gly Pro Ser Ser Asp Glu Ile Arg Tyr Gly Val 
145                 150                 155                 160 


Val Ala Leu Lys Gln Ala Ser Val Phe Ser Phe Gly Leu Gly Ala Gln 
                165                 170                 175     


Ala Ala Ser Arg Ala Glu Leu Gln His Ile Ala Thr Asp Asp Asn Leu 
            180                 185                 190         


Val Phe Thr Val Pro Glu Phe Arg Ser Phe Gly Asp Leu Gln Glu Lys 
        195                 200                 205             


Leu Leu Pro Tyr Ile Val Gly Val Ala Gln Arg His Ile Val Leu Lys 
    210                 215                 220                 


Pro Pro Thr Ile Val Thr Gln Val Ile Glu Val Asn Lys Arg Asp Ile 
225                 230                 235                 240 


Val Phe Leu Val Asp Gly Ser Ser Ala Leu Gly Leu Ala Asn Phe Asn 
                245                 250                 255     


Ala Ile Arg Asp Phe Ile Ala Lys Val Ile Gln Arg Leu Glu Ile Gly 
            260                 265                 270         


Gln Asp Leu Ile Gln Val Ala Val Ala Gln Tyr Ala Asp Thr Val Arg 
        275                 280                 285             


Pro Glu Phe Tyr Phe Asn Thr His Pro Thr Lys Arg Glu Val Ile Thr 
    290                 295                 300                 


Ala Val Arg Lys Met Lys Pro Leu Asp Gly Ser Ala Leu Tyr Thr Gly 
305                 310                 315                 320 


Ser Ala Leu Asp Phe Val Arg Asn Asn Leu Phe Thr Ser Ser Ala Gly 
                325                 330                 335     


Tyr Arg Ala Ala Glu Gly Ile Pro Lys Leu Leu Val Leu Ile Thr Gly 
            340                 345                 350         


Gly Lys Ser Leu Asp Glu Ile Ser Gln Pro Ala Gln Glu Leu Lys Arg 
        355                 360                 365             


Ser Ser Ile Met Ala Phe Ala Ile Gly Asn Lys Gly Ala Asp Gln Ala 
    370                 375                 380                 


Glu Leu Glu Glu Ile Ala Phe Asp Ser Ser Leu Val Phe Ile Pro Ala 
385                 390                 395                 400 


Glu Phe Arg Ala Ala Pro Leu Gln Gly Met Leu Pro Gly Leu Leu Ala 
                405                 410                 415     


Pro Leu Arg Thr Leu Ser Gly Thr Pro Glu Val His Ser Asn Lys Arg 
            420                 425                 430         


Asp Ile Ile Phe Leu Leu Asp Gly Ser Ala Asn Val Gly Lys Thr Asn 
        435                 440                 445             


Phe Pro Tyr Val Arg Asp Phe Val Met Asn Leu Val Asn Ser Leu Asp 
    450                 455                 460                 


Ile Gly Asn Asp Asn Ile Arg Val Gly Leu Val Gln Phe Ser Asp Thr 
465                 470                 475                 480 


Pro Val Thr Glu Phe Ser Leu Asn Thr Tyr Gln Thr Lys Ser Asp Ile 
                485                 490                 495     


Leu Gly His Leu Arg Gln Leu Gln Leu Gln Gly Gly Ser Gly Leu Asn 
            500                 505                 510         


Thr Gly Ser Ala Leu Ser Tyr Val Tyr Ala Asn His Phe Thr Glu Ala 
        515                 520                 525             


Gly Gly Ser Arg Ile Arg Glu His Val Pro Gln Leu Leu Leu Leu Leu 
    530                 535                 540                 


Thr Ala Gly Gln Ser Glu Asp Ser Tyr Leu Gln Ala Ala Asn Ala Leu 
545                 550                 555                 560 


Thr Arg Ala Gly Ile Leu Thr Phe Cys Val Gly Ala Ser Gln Ala Asn 
                565                 570                 575     


Lys Ala Glu Leu Glu Gln Ile Ala Phe Asn Pro Ser Leu Val Tyr Leu 
            580                 585                 590         


Met Asp Asp Phe Ser Ser Leu Pro Ala Leu Pro Gln Gln Leu Ile Gln 
        595                 600                 605             


Pro Leu Thr Thr Tyr Val Ser Gly Gly Val Glu Glu Val Pro Leu Ala 
    610                 615                 620                 


Gln Pro Glu Ser Lys Arg Asp Ile Leu Phe Leu Phe Asp Gly Ser Ala 
625                 630                 635                 640 


Asn Leu Val Gly Gln Phe Pro Val Val Arg Asp Phe Leu Tyr Lys Ile 
                645                 650                 655     


Ile Asp Glu Leu Asn Val Lys Pro Glu Gly Thr Arg Ile Ala Val Ala 
            660                 665                 670         


Gln Tyr Ser Asp Asp Val Lys Val Glu Ser Arg Phe Asp Glu His Gln 
        675                 680                 685             


Ser Lys Pro Glu Ile Leu Asn Leu Val Lys Arg Met Lys Ile Lys Thr 
    690                 695                 700                 


Gly Lys Ala Leu Asn Leu Gly Tyr Ala Leu Asp Tyr Ala Gln Arg Tyr 
705                 710                 715                 720 


Ile Phe Val Lys Ser Ala Gly Ser Arg Ile Glu Asp Gly Val Leu Gln 
                725                 730                 735     


Phe Leu Val Leu Leu Val Ala Gly Arg Ser Ser Asp Arg Val Asp Gly 
            740                 745                 750         


Pro Ala Ser Asn Leu Lys Gln Ser Gly Val Val Pro Phe Ile Phe Gln 
        755                 760                 765             


Ala Lys Asn Ala Asp Pro Ala Glu Leu Glu Gln Ile Val Leu Ser Pro 
    770                 775                 780                 


Ala Phe Ile Leu Ala Ala Glu Ser Leu Pro Lys Ile Gly Asp Leu His 
785                 790                 795                 800 


Pro Gln Ile Val Asn Leu Leu Lys Ser Val His Asn Gly Ala Pro Ala 
                805                 810                 815     


Pro Val Ser Gly Glu Lys Asp Val Val Phe Leu Leu Asp Gly Ser Glu 
            820                 825                 830         


Gly Val Arg Ser Gly Phe Pro Leu Leu Lys Glu Phe Val Gln Arg Val 
        835                 840                 845             


Val Glu Ser Leu Asp Val Gly Gln Asp Arg Val Arg Val Ala Val Val 
    850                 855                 860                 


Gln Tyr Ser Asp Arg Thr Arg Pro Glu Phe Tyr Leu Asn Ser Tyr Met 
865                 870                 875                 880 


Asn Lys Gln Asp Val Val Asn Ala Val Arg Gln Leu Thr Leu Leu Gly 
                885                 890                 895     


Gly Pro Thr Pro Asn Thr Gly Ala Ala Leu Glu Phe Val Leu Arg Asn 
            900                 905                 910         


Ile Leu Val Ser Ser Ala Gly Ser Arg Ile Thr Glu Gly Val Pro Gln 
        915                 920                 925             


Leu Leu Ile Val Leu Thr Ala Asp Arg Ser Gly Asp Asp Val Arg Asn 
    930                 935                 940                 


Pro Ser Val Val Val Lys Arg Gly Gly Ala Val Pro Ile Gly Ile Gly 
945                 950                 955                 960 


Ile Gly Asn Ala Asp Ile Thr Glu Met Gln Thr Ile Ser Phe Ile Pro 
                965                 970                 975     


Asp Phe Ala Val Ala Ile Pro Thr Phe Arg Gln Leu Gly Thr Val Gln 
            980                 985                 990         


Gln Val Ile Ser Glu Arg Val Thr  Gln Leu Thr Arg Glu  Glu Leu Ser 
        995                 1000                 1005             


Arg Leu  Gln Pro Val Leu Gln  Pro Leu Pro Ser Pro  Gly Val Gly 
    1010                 1015                 1020             


Gly Lys  Arg Asp Val Val Phe  Leu Ile Asp Gly Ser  Gln Ser Ala 
    1025                 1030                 1035             


Gly Pro  Glu Phe Gln Tyr Val  Arg Thr Leu Ile Glu  Arg Leu Val 
    1040                 1045                 1050             


Asp Tyr  Leu Asp Val Gly Phe  Asp Thr Thr Arg Val  Ala Val Ile 
    1055                 1060                 1065             


Gln Phe  Ser Asp Asp Pro Lys  Val Glu Phe Leu Leu  Asn Ala His 
    1070                 1075                 1080             


Ser Ser  Lys Asp Glu Val Gln  Asn Ala Val Gln Arg  Leu Arg Pro 
    1085                 1090                 1095             


Lys Gly  Gly Arg Gln Ile Asn  Val Gly Asn Ala Leu  Glu Tyr Val 
    1100                 1105                 1110             


Ser Arg  Asn Ile Phe Lys Arg  Pro Leu Gly Ser Arg  Ile Glu Glu 
    1115                 1120                 1125             


Gly Val  Pro Gln Phe Leu Val  Leu Ile Ser Ser Gly  Lys Ser Asp 
    1130                 1135                 1140             


Asp Glu  Val Asp Asp Pro Ala  Val Glu Leu Lys Gln  Phe Gly Val 
    1145                 1150                 1155             


Ala Pro  Phe Thr Ile Ala Arg  Asn Ala Asp Gln Glu  Glu Leu Val 
    1160                 1165                 1170             


Lys Ile  Ser Leu Ser Pro Glu  Tyr Val Phe Ser Val  Ser Thr Phe 
    1175                 1180                 1185             


Arg Glu  Leu Pro Ser Leu Glu  Gln Lys Leu Leu Thr  Pro Ile Thr 
    1190                 1195                 1200             


Thr Leu  Thr Ser Glu Gln Ile  Gln Lys Leu Leu Ala  Ser Thr Arg 
    1205                 1210                 1215             


Tyr Pro  Pro Pro Ala Val Glu  Ser Asp Ala Ala Asp  Ile Val Phe 
    1220                 1225                 1230             


Leu Ile  Asp Ser Ser Glu Gly  Val Arg Pro Asp Gly  Phe Ala His 
    1235                 1240                 1245             


Ile Arg  Asp Phe Val Ser Arg  Ile Val Arg Arg Leu  Asn Ile Gly 
    1250                 1255                 1260             


Pro Ser  Lys Val Arg Val Gly  Val Val Gln Phe Ser  Asn Asp Val 
    1265                 1270                 1275             


Phe Pro  Glu Phe Tyr Leu Lys  Thr Tyr Arg Ser Gln  Ala Pro Val 
    1280                 1285                 1290             


Leu Asp  Ala Ile Arg Arg Leu  Arg Leu Arg Gly Gly  Ser Pro Leu 
    1295                 1300                 1305             


Asn Thr  Gly Lys Ala Leu Glu  Phe Val Ala Arg Asn  Leu Phe Val 
    1310                 1315                 1320             


Lys Ser  Ala Gly Ser Arg Ile  Glu Asp Gly Val Pro  Gln His Leu 
    1325                 1330                 1335             


Val Leu  Val Leu Gly Gly Lys  Ser Gln Asp Asp Val  Ser Arg Phe 
    1340                 1345                 1350             


Ala Gln  Val Ile Arg Ser Ser  Gly Ile Val Ser Leu  Gly Val Gly 
    1355                 1360                 1365             


Asp Arg  Asn Ile Asp Arg Thr  Glu Leu Gln Thr Ile  Thr Asn Asp 
    1370                 1375                 1380             


Pro Arg  Leu Val Phe Thr Val  Arg Glu Phe Arg Glu  Leu Pro Asn 
    1385                 1390                 1395             


Ile Glu  Glu Arg Ile Met Asn  Ser Phe Gly Pro Ser  Ala Ala Thr 
    1400                 1405                 1410             


Pro Ala  Pro Pro Gly Val Asp  Thr Pro Pro Pro Ser  Arg Pro Glu 
    1415                 1420                 1425             


Lys Lys  Lys Ala Asp Ile Val  Phe Leu Leu Asp Gly  Ser Ile Asn 
    1430                 1435                 1440             


Phe Arg  Arg Asp Ser Phe Gln  Glu Val Leu Arg Phe  Val Ser Glu 
    1445                 1450                 1455             


Ile Val  Asp Thr Val Tyr Glu  Asp Gly Asp Ser Ile  Gln Val Gly 
    1460                 1465                 1470             


Leu Val  Gln Tyr Asn Ser Asp  Pro Thr Asp Glu Phe  Phe Leu Lys 
    1475                 1480                 1485             


Asp Phe  Ser Thr Lys Arg Gln  Ile Ile Asp Ala Ile  Asn Lys Val 
    1490                 1495                 1500             


Val Tyr  Lys Gly Gly Arg His  Ala Asn Thr Lys Val  Gly Leu Glu 
    1505                 1510                 1515             


His Leu  Arg Val Asn His Phe  Val Pro Glu Ala Gly  Ser Arg Leu 
    1520                 1525                 1530             


Asp Gln  Arg Val Pro Gln Ile  Ala Phe Val Ile Thr  Gly Gly Lys 
    1535                 1540                 1545             


Ser Val  Glu Asp Ala Gln Asp  Val Ser Leu Ala Leu  Thr Gln Arg 
    1550                 1555                 1560             


Gly Val  Lys Val Phe Ala Val  Gly Val Arg Asn Ile  Asp Ser Glu 
    1565                 1570                 1575             


Glu Val  Gly Lys Ile Ala Ser  Asn Ser Ala Thr Ala  Phe Arg Val 
    1580                 1585                 1590             


Gly Asn  Val Gln Glu Leu Ser  Glu Leu Ser Glu Gln  Val Leu Glu 
    1595                 1600                 1605             


Thr Leu  His Asp Ala Met His  Glu Thr Leu Cys Pro  Gly Val Thr 
    1610                 1615                 1620             


Asp Ala  Ala Lys Ala Cys Asn  Leu Asp Val Ile Leu  Gly Phe Asp 
    1625                 1630                 1635             


Gly Ser  Arg Asp Gln Asn Val  Phe Val Ala Gln Lys  Gly Phe Glu 
    1640                 1645                 1650             


Ser Lys  Val Asp Ala Ile Leu  Asn Arg Ile Ser Gln  Met His Arg 
    1655                 1660                 1665             


Val Ser  Cys Ser Gly Gly Arg  Ser Pro Thr Val Arg  Val Ser Val 
    1670                 1675                 1680             


Val Ala  Asn Thr Pro Ser Gly  Pro Val Glu Ala Phe  Asp Phe Asp 
    1685                 1690                 1695             


Glu Tyr  Gln Pro Glu Met Leu  Glu Lys Phe Arg Asn  Met Arg Ser 
    1700                 1705                 1710             


Gln His  Pro Tyr Val Leu Thr  Glu Asp Thr Leu Lys  Val Tyr Leu 
    1715                 1720                 1725             


Asn Lys  Phe Arg Gln Ser Ser  Pro Asp Ser Val Lys  Val Val Ile 
    1730                 1735                 1740             


His Phe  Thr Asp Gly Ala Asp  Gly Asp Leu Ala Asp  Leu His Arg 
    1745                 1750                 1755             


Ala Ser  Glu Asn Leu Arg Gln  Glu Gly Val Arg Ala  Leu Ile Leu 
    1760                 1765                 1770             


Val Gly  Leu Glu Arg Val Val  Asn Leu Glu Arg Leu  Met His Leu 
    1775                 1780                 1785             


Glu Phe  Gly Arg Gly Phe Met  Tyr Asp Arg Pro Leu  Arg Leu Asn 
    1790                 1795                 1800             


Leu Leu  Asp Leu Asp Tyr Glu  Leu Ala Glu Gln Leu  Asp Asn Ile 
    1805                 1810                 1815             


Ala Glu  Lys Ala Cys Cys Gly  Val Pro Cys Lys Cys  Ser Gly Gln 
    1820                 1825                 1830             


Arg Gly  Asp Arg Gly Pro Ile  Gly Ser Ile Gly Pro  Lys Gly Ile 
    1835                 1840                 1845             


Pro Gly  Glu Asp Gly Tyr Arg  Gly Tyr Pro Gly Asp  Glu Gly Gly 
    1850                 1855                 1860             


Pro Gly  Glu Arg Gly Pro Pro  Gly Val Asn Gly Thr  Gln Gly Phe 
    1865                 1870                 1875             


Gln Gly  Cys Pro Gly Gln Arg  Gly Val Lys Gly Ser  Arg Gly Phe 
    1880                 1885                 1890             


Pro Gly  Glu Lys Gly Glu Val  Gly Glu Ile Gly Leu  Asp Gly Leu 
    1895                 1900                 1905             


Asp Gly  Glu Asp Gly Asp Lys  Gly Leu Pro Gly Ser  Ser Gly Glu 
    1910                 1915                 1920             


Lys Gly  Asn Pro Gly Arg Arg  Gly Asp Lys Gly Pro  Arg Gly Glu 
    1925                 1930                 1935             


Lys Gly  Glu Arg Gly Asp Val  Gly Ile Arg Gly Asp  Pro Gly Asn 
    1940                 1945                 1950             


Pro Gly  Gln Asp Ser Gln Glu  Arg Gly Pro Lys Gly  Glu Thr Gly 
    1955                 1960                 1965             


Asp Leu  Gly Pro Met Gly Val  Pro Gly Arg Asp Gly  Val Pro Gly 
    1970                 1975                 1980             


Gly Pro  Gly Glu Thr Gly Lys  Asn Gly Gly Phe Gly  Arg Arg Gly 
    1985                 1990                 1995             


Pro Pro  Gly Ala Lys Gly Asn  Lys Gly Gly Pro Gly  Gln Pro Gly 
    2000                 2005                 2010             


Phe Glu  Gly Glu Gln Gly Thr  Arg Gly Ala Gln Gly  Pro Ala Gly 
    2015                 2020                 2025             


Pro Ala  Gly Pro Pro Gly Leu  Ile Gly Glu Gln Gly  Ile Ser Gly 
    2030                 2035                 2040             


Pro Arg  Gly Ser Gly Gly Ala  Ala Gly Ala Pro Gly  Glu Arg Gly 
    2045                 2050                 2055             


Arg Thr  Gly Pro Leu Gly Arg  Lys Gly Glu Pro Gly  Glu Pro Gly 
    2060                 2065                 2070             


Pro Lys  Gly Gly Ile Gly Asn  Arg Gly Pro Arg Gly  Glu Thr Gly 
    2075                 2080                 2085             


Asp Asp  Gly Arg Asp Gly Val  Gly Ser Glu Gly Arg  Arg Gly Lys 
    2090                 2095                 2100             


Lys Gly  Glu Arg Gly Phe Pro  Gly Tyr Pro Gly Pro  Lys Gly Asn 
    2105                 2110                 2115             


Pro Gly  Glu Pro Gly Leu Asn  Gly Thr Thr Gly Pro  Lys Gly Ile 
    2120                 2125                 2130             


Arg Gly  Arg Arg Gly Asn Ser  Gly Pro Pro Gly Ile  Val Gly Gln 
    2135                 2140                 2145             


Lys Gly  Asp Pro Gly Tyr Pro  Gly Pro Ala Gly Pro  Lys Gly Asn 
    2150                 2155                 2160             


Arg Gly  Asp Ser Ile Asp Gln  Cys Ala Leu Ile Gln  Ser Ile Lys 
    2165                 2170                 2175             


Asp Lys  Cys Pro Cys Cys Tyr  Gly Pro Leu Glu Cys  Pro Val Phe 
    2180                 2185                 2190             


Pro Thr  Glu Leu Ala Phe Ala  Leu Asp Thr Ser Glu  Gly Val Asn 
    2195                 2200                 2205             


Gln Asp  Thr Phe Gly Arg Met  Arg Asp Val Val Leu  Ser Ile Val 
    2210                 2215                 2220             


Asn Asp  Leu Thr Ile Ala Glu  Ser Asn Cys Pro Arg  Gly Ala Arg 
    2225                 2230                 2235             


Val Ala  Val Val Thr Tyr Asn  Asn Glu Val Thr Thr  Glu Ile Arg 
    2240                 2245                 2250             


Phe Ala  Asp Ser Lys Arg Lys  Ser Val Leu Leu Asp  Lys Ile Lys 
    2255                 2260                 2265             


Asn Leu  Gln Val Ala Leu Thr  Ser Lys Gln Gln Ser  Leu Glu Thr 
    2270                 2275                 2280             


Ala Met  Ser Phe Val Ala Arg  Asn Thr Phe Lys Arg  Val Arg Asn 
    2285                 2290                 2295             


Gly Phe  Leu Met Arg Lys Val  Ala Val Phe Phe Ser  Asn Thr Pro 
    2300                 2305                 2310             


Thr Arg  Ala Ser Pro Gln Leu  Arg Glu Ala Val Leu  Lys Leu Ser 
    2315                 2320                 2325             


Asp Ala  Gly Ile Thr Pro Leu  Phe Leu Thr Arg Gln  Glu Asp Arg 
    2330                 2335                 2340             


Gln Leu  Ile Asn Ala Leu Gln  Ile Asn Asn Thr Ala  Val Gly His 
    2345                 2350                 2355             


Ala Leu  Val Leu Pro Ala Gly  Arg Asp Leu Thr Asp  Phe Leu Glu 
    2360                 2365                 2370             


Asn Val  Leu Thr Cys His Val  Cys Leu Asp Ile Cys  Asn Ile Asp 
    2375                 2380                 2385             


Pro Ser  Cys Gly Phe Gly Ser  Trp Arg Pro Ser Phe  Arg Asp Arg 
    2390                 2395                 2400             


Arg Ala  Ala Gly Ser Asp Val  Asp Ile Asp Met Ala  Phe Ile Leu 
    2405                 2410                 2415             


Asp Ser  Ala Glu Thr Thr Thr  Leu Phe Gln Phe Asn  Glu Met Lys 
    2420                 2425                 2430             


Lys Tyr  Ile Ala Tyr Leu Val  Arg Gln Leu Asp Met  Ser Pro Asp 
    2435                 2440                 2445             


Pro Lys  Ala Ser Gln His Phe  Ala Arg Val Ala Val  Val Gln His 
    2450                 2455                 2460             


Ala Pro  Ser Glu Ser Val Asp  Asn Ala Ser Met Pro  Pro Val Lys 
    2465                 2470                 2475             


Val Glu  Phe Ser Leu Thr Asp  Tyr Gly Ser Lys Glu  Lys Leu Val 
    2480                 2485                 2490             


Asp Phe  Leu Ser Arg Gly Met  Thr Gln Leu Gln Gly  Thr Arg Ala 
    2495                 2500                 2505             


Leu Gly  Ser Ala Ile Glu Tyr  Thr Ile Glu Asn Val  Phe Glu Ser 
    2510                 2515                 2520             


Ala Pro  Asn Pro Arg Asp Leu  Lys Ile Val Val Leu  Met Leu Thr 
    2525                 2530                 2535             


Gly Glu  Val Pro Glu Gln Gln  Leu Glu Glu Ala Gln  Arg Val Ile 
    2540                 2545                 2550             


Leu Gln  Ala Lys Cys Lys Gly  Tyr Phe Phe Val Val  Leu Gly Ile 
    2555                 2560                 2565             


Gly Arg  Lys Val Asn Ile Lys  Glu Val Tyr Thr Phe  Ala Ser Glu 
    2570                 2575                 2580             


Pro Asn  Asp Val Phe Phe Lys  Leu Val Asp Lys Ser  Thr Glu Leu 
    2585                 2590                 2595             


Asn Glu  Glu Pro Leu Met Arg  Phe Gly Arg Leu Leu  Pro Ser Phe 
    2600                 2605                 2610             


Val Ser  Ser Glu Asn Ala Phe  Tyr Leu Ser Pro Asp  Ile Arg Lys 
    2615                 2620                 2625             


Gln Cys  Asp Trp Phe Gln Gly  Asp Gln Pro Thr Lys  Asn Leu Val 
    2630                 2635                 2640             


Lys Phe  Gly His Lys Gln Val  Asn Val Pro Asn Asn  Val Thr Ser 
    2645                 2650                 2655             


Ser Pro  Thr Ser Asn Pro Val  Thr Thr Thr Lys Pro  Val Thr Thr 
    2660                 2665                 2670             


Thr Lys  Pro Val Thr Thr Thr  Thr Lys Pro Val Thr  Thr Thr Thr 
    2675                 2680                 2685             


Lys Pro  Val Thr Ile Ile Asn  Gln Pro Ser Val Lys  Pro Ala Ala 
    2690                 2695                 2700             


Ala Lys  Pro Ala Pro Ala Lys  Pro Val Ala Ala Lys  Pro Val Ala 
    2705                 2710                 2715             


Thr Lys  Met Ala Thr Val Arg  Pro Pro Val Ala Val  Lys Pro Ala 
    2720                 2725                 2730             


Thr Ala  Ala Lys Pro Val Ala  Ala Lys Pro Ala Ala  Val Arg Pro 
    2735                 2740                 2745             


Pro Ala  Ala Ala Ala Ala Lys  Pro Val Ala Thr Lys  Pro Glu Val 
    2750                 2755                 2760             


Pro Arg  Pro Gln Ala Ala Lys  Pro Ala Ala Thr Lys  Pro Ala Thr 
    2765                 2770                 2775             


Thr Lys  Pro Met Val Lys Met  Ser Arg Glu Val Gln  Val Phe Glu 
    2780                 2785                 2790             


Ile Thr  Glu Asn Ser Ala Lys  Leu His Trp Glu Arg  Ala Glu Pro 
    2795                 2800                 2805             


Pro Gly  Pro Tyr Phe Tyr Asp  Leu Thr Val Thr Ser  Ala His Asp 
    2810                 2815                 2820             


Gln Ser  Leu Val Leu Lys Gln  Asn Leu Thr Val Thr  Asp Arg Val 
    2825                 2830                 2835             


Ile Gly  Gly Leu Leu Ala Gly  Gln Thr Tyr His Val  Ala Val Val 
    2840                 2845                 2850             


Cys Tyr  Leu Arg Ser Gln Val  Arg Ala Thr Tyr His  Gly Ser Phe 
    2855                 2860                 2865             


Ser Thr  Lys Lys Ser Gln Pro  Pro Pro Pro Gln Pro  Ala Arg Ser 
    2870                 2875                 2880             


Ala Ser  Ser Ser Thr Ile Asn  Leu Met Val Ser Thr  Glu Pro Leu 
    2885                 2890                 2895             


Ala Leu  Thr Glu Thr Asp Ile  Cys Lys Leu Pro Lys  Asp Glu Gly 
    2900                 2905                 2910             


Thr Cys  Arg Asp Phe Ile Leu  Lys Trp Tyr Tyr Asp  Pro Asn Thr 
    2915                 2920                 2925             


Lys Ser  Cys Ala Arg Phe Trp  Tyr Gly Gly Cys Gly  Gly Asn Glu 
    2930                 2935                 2940             


Asn Lys  Phe Gly Ser Gln Lys  Glu Cys Glu Lys Val  Cys Ala Pro 
    2945                 2950                 2955             


Val Leu  Ala Lys Pro Gly Val  Ile Ser Val Met Gly  Thr 
    2960                 2965                 2970     


<210>  3332
<211>  3177
<212>  PRT
<213>  Homo Sapiens

<400>  3332

Met Arg Lys His Arg His Leu Pro Leu Val Ala Val Phe Cys Leu Phe 
1               5                   10                  15      


Leu Ser Gly Phe Pro Thr Thr His Ala Gln Gln Gln Gln Ala Asp Val 
            20                  25                  30          


Lys Asn Gly Ala Ala Ala Asp Ile Ile Phe Leu Val Asp Ser Ser Trp 
        35                  40                  45              


Thr Ile Gly Glu Glu His Phe Gln Leu Val Arg Glu Phe Leu Tyr Asp 
    50                  55                  60                  


Val Val Lys Ser Leu Ala Val Gly Glu Asn Asp Phe His Phe Ala Leu 
65                  70                  75                  80  


Val Gln Phe Asn Gly Asn Pro His Thr Glu Phe Leu Leu Asn Thr Tyr 
                85                  90                  95      


Arg Thr Lys Gln Glu Val Leu Ser His Ile Ser Asn Met Ser Tyr Ile 
            100                 105                 110         


Gly Gly Thr Asn Gln Thr Gly Lys Gly Leu Glu Tyr Ile Met Gln Ser 
        115                 120                 125             


His Leu Thr Lys Ala Ala Gly Ser Arg Ala Gly Asp Gly Val Pro Gln 
    130                 135                 140                 


Val Ile Val Val Leu Thr Asp Gly His Ser Lys Asp Gly Leu Ala Leu 
145                 150                 155                 160 


Pro Ser Ala Glu Leu Lys Ser Ala Asp Val Asn Val Phe Ala Ile Gly 
                165                 170                 175     


Val Glu Asp Ala Asp Glu Gly Ala Leu Lys Glu Ile Ala Ser Glu Pro 
            180                 185                 190         


Leu Asn Met His Met Phe Asn Leu Glu Asn Phe Thr Ser Leu His Asp 
        195                 200                 205             


Ile Val Gly Asn Leu Val Ser Cys Val His Ser Ser Val Ser Pro Glu 
    210                 215                 220                 


Arg Ala Gly Asp Thr Glu Thr Leu Lys Asp Ile Thr Ala Gln Asp Ser 
225                 230                 235                 240 


Ala Asp Ile Ile Phe Leu Ile Asp Gly Ser Asn Asn Thr Gly Ser Val 
                245                 250                 255     


Asn Phe Ala Val Ile Leu Asp Phe Leu Val Asn Leu Leu Glu Lys Leu 
            260                 265                 270         


Pro Ile Gly Thr Gln Gln Ile Arg Val Gly Val Val Gln Phe Ser Asp 
        275                 280                 285             


Glu Pro Arg Thr Met Phe Ser Leu Asp Thr Tyr Ser Thr Lys Ala Gln 
    290                 295                 300                 


Val Leu Gly Ala Val Lys Ala Leu Gly Phe Ala Gly Gly Glu Leu Ala 
305                 310                 315                 320 


Asn Ile Gly Leu Ala Leu Asp Phe Val Val Glu Asn His Phe Thr Arg 
                325                 330                 335     


Ala Gly Gly Ser Arg Val Glu Glu Gly Val Pro Gln Val Leu Val Leu 
            340                 345                 350         


Ile Ser Ala Gly Pro Ser Ser Asp Glu Ile Arg Tyr Gly Val Val Ala 
        355                 360                 365             


Leu Lys Gln Ala Ser Val Phe Ser Phe Gly Leu Gly Ala Gln Ala Ala 
    370                 375                 380                 


Ser Arg Ala Glu Leu Gln His Ile Ala Thr Asp Asp Asn Leu Val Phe 
385                 390                 395                 400 


Thr Val Pro Glu Phe Arg Ser Phe Gly Asp Leu Gln Glu Lys Leu Leu 
                405                 410                 415     


Pro Tyr Ile Val Gly Val Ala Gln Arg His Ile Val Leu Lys Pro Pro 
            420                 425                 430         


Thr Ile Val Thr Gln Val Ile Glu Val Asn Lys Arg Asp Ile Val Phe 
        435                 440                 445             


Leu Val Asp Gly Ser Ser Ala Leu Gly Leu Ala Asn Phe Asn Ala Ile 
    450                 455                 460                 


Arg Asp Phe Ile Ala Lys Val Ile Gln Arg Leu Glu Ile Gly Gln Asp 
465                 470                 475                 480 


Leu Ile Gln Val Ala Val Ala Gln Tyr Ala Asp Thr Val Arg Pro Glu 
                485                 490                 495     


Phe Tyr Phe Asn Thr His Pro Thr Lys Arg Glu Val Ile Thr Ala Val 
            500                 505                 510         


Arg Lys Met Lys Pro Leu Asp Gly Ser Ala Leu Tyr Thr Gly Ser Ala 
        515                 520                 525             


Leu Asp Phe Val Arg Asn Asn Leu Phe Thr Ser Ser Ala Gly Tyr Arg 
    530                 535                 540                 


Ala Ala Glu Gly Ile Pro Lys Leu Leu Val Leu Ile Thr Gly Gly Lys 
545                 550                 555                 560 


Ser Leu Asp Glu Ile Ser Gln Pro Ala Gln Glu Leu Lys Arg Ser Ser 
                565                 570                 575     


Ile Met Ala Phe Ala Ile Gly Asn Lys Gly Ala Asp Gln Ala Glu Leu 
            580                 585                 590         


Glu Glu Ile Ala Phe Asp Ser Ser Leu Val Phe Ile Pro Ala Glu Phe 
        595                 600                 605             


Arg Ala Ala Pro Leu Gln Gly Met Leu Pro Gly Leu Leu Ala Pro Leu 
    610                 615                 620                 


Arg Thr Leu Ser Gly Thr Pro Glu Val His Ser Asn Lys Arg Asp Ile 
625                 630                 635                 640 


Ile Phe Leu Leu Asp Gly Ser Ala Asn Val Gly Lys Thr Asn Phe Pro 
                645                 650                 655     


Tyr Val Arg Asp Phe Val Met Asn Leu Val Asn Ser Leu Asp Ile Gly 
            660                 665                 670         


Asn Asp Asn Ile Arg Val Gly Leu Val Gln Phe Ser Asp Thr Pro Val 
        675                 680                 685             


Thr Glu Phe Ser Leu Asn Thr Tyr Gln Thr Lys Ser Asp Ile Leu Gly 
    690                 695                 700                 


His Leu Arg Gln Leu Gln Leu Gln Gly Gly Ser Gly Leu Asn Thr Gly 
705                 710                 715                 720 


Ser Ala Leu Ser Tyr Val Tyr Ala Asn His Phe Thr Glu Ala Gly Gly 
                725                 730                 735     


Ser Arg Ile Arg Glu His Val Pro Gln Leu Leu Leu Leu Leu Thr Ala 
            740                 745                 750         


Gly Gln Ser Glu Asp Ser Tyr Leu Gln Ala Ala Asn Ala Leu Thr Arg 
        755                 760                 765             


Ala Gly Ile Leu Thr Phe Cys Val Gly Ala Ser Gln Ala Asn Lys Ala 
    770                 775                 780                 


Glu Leu Glu Gln Ile Ala Phe Asn Pro Ser Leu Val Tyr Leu Met Asp 
785                 790                 795                 800 


Asp Phe Ser Ser Leu Pro Ala Leu Pro Gln Gln Leu Ile Gln Pro Leu 
                805                 810                 815     


Thr Thr Tyr Val Ser Gly Gly Val Glu Glu Val Pro Leu Ala Gln Pro 
            820                 825                 830         


Glu Ser Lys Arg Asp Ile Leu Phe Leu Phe Asp Gly Ser Ala Asn Leu 
        835                 840                 845             


Val Gly Gln Phe Pro Val Val Arg Asp Phe Leu Tyr Lys Ile Ile Asp 
    850                 855                 860                 


Glu Leu Asn Val Lys Pro Glu Gly Thr Arg Ile Ala Val Ala Gln Tyr 
865                 870                 875                 880 


Ser Asp Asp Val Lys Val Glu Ser Arg Phe Asp Glu His Gln Ser Lys 
                885                 890                 895     


Pro Glu Ile Leu Asn Leu Val Lys Arg Met Lys Ile Lys Thr Gly Lys 
            900                 905                 910         


Ala Leu Asn Leu Gly Tyr Ala Leu Asp Tyr Ala Gln Arg Tyr Ile Phe 
        915                 920                 925             


Val Lys Ser Ala Gly Ser Arg Ile Glu Asp Gly Val Leu Gln Phe Leu 
    930                 935                 940                 


Val Leu Leu Val Ala Gly Arg Ser Ser Asp Arg Val Asp Gly Pro Ala 
945                 950                 955                 960 


Ser Asn Leu Lys Gln Ser Gly Val Val Pro Phe Ile Phe Gln Ala Lys 
                965                 970                 975     


Asn Ala Asp Pro Ala Glu Leu Glu Gln Ile Val Leu Ser Pro Ala Phe 
            980                 985                 990         


Ile Leu Ala Ala Glu Ser Leu Pro  Lys Ile Gly Asp Leu  His Pro Gln 
        995                 1000                 1005             


Ile Val  Asn Leu Leu Lys Ser  Val His Asn Gly Ala  Pro Ala Pro 
    1010                 1015                 1020             


Val Ser  Gly Glu Lys Asp Val  Val Phe Leu Leu Asp  Gly Ser Glu 
    1025                 1030                 1035             


Gly Val  Arg Ser Gly Phe Pro  Leu Leu Lys Glu Phe  Val Gln Arg 
    1040                 1045                 1050             


Val Val  Glu Ser Leu Asp Val  Gly Gln Asp Arg Val  Arg Val Ala 
    1055                 1060                 1065             


Val Val  Gln Tyr Ser Asp Arg  Thr Arg Pro Glu Phe  Tyr Leu Asn 
    1070                 1075                 1080             


Ser Tyr  Met Asn Lys Gln Asp  Val Val Asn Ala Val  Arg Gln Leu 
    1085                 1090                 1095             


Thr Leu  Leu Gly Gly Pro Thr  Pro Asn Thr Gly Ala  Ala Leu Glu 
    1100                 1105                 1110             


Phe Val  Leu Arg Asn Ile Leu  Val Ser Ser Ala Gly  Ser Arg Ile 
    1115                 1120                 1125             


Thr Glu  Gly Val Pro Gln Leu  Leu Ile Val Leu Thr  Ala Asp Arg 
    1130                 1135                 1140             


Ser Gly  Asp Asp Val Arg Asn  Pro Ser Val Val Val  Lys Arg Gly 
    1145                 1150                 1155             


Gly Ala  Val Pro Ile Gly Ile  Gly Ile Gly Asn Ala  Asp Ile Thr 
    1160                 1165                 1170             


Glu Met  Gln Thr Ile Ser Phe  Ile Pro Asp Phe Ala  Val Ala Ile 
    1175                 1180                 1185             


Pro Thr  Phe Arg Gln Leu Gly  Thr Val Gln Gln Val  Ile Ser Glu 
    1190                 1195                 1200             


Arg Val  Thr Gln Leu Thr Arg  Glu Glu Leu Ser Arg  Leu Gln Pro 
    1205                 1210                 1215             


Val Leu  Gln Pro Leu Pro Ser  Pro Gly Val Gly Gly  Lys Arg Asp 
    1220                 1225                 1230             


Val Val  Phe Leu Ile Asp Gly  Ser Gln Ser Ala Gly  Pro Glu Phe 
    1235                 1240                 1245             


Gln Tyr  Val Arg Thr Leu Ile  Glu Arg Leu Val Asp  Tyr Leu Asp 
    1250                 1255                 1260             


Val Gly  Phe Asp Thr Thr Arg  Val Ala Val Ile Gln  Phe Ser Asp 
    1265                 1270                 1275             


Asp Pro  Lys Val Glu Phe Leu  Leu Asn Ala His Ser  Ser Lys Asp 
    1280                 1285                 1290             


Glu Val  Gln Asn Ala Val Gln  Arg Leu Arg Pro Lys  Gly Gly Arg 
    1295                 1300                 1305             


Gln Ile  Asn Val Gly Asn Ala  Leu Glu Tyr Val Ser  Arg Asn Ile 
    1310                 1315                 1320             


Phe Lys  Arg Pro Leu Gly Ser  Arg Ile Glu Glu Gly  Val Pro Gln 
    1325                 1330                 1335             


Phe Leu  Val Leu Ile Ser Ser  Gly Lys Ser Asp Asp  Glu Val Asp 
    1340                 1345                 1350             


Asp Pro  Ala Val Glu Leu Lys  Gln Phe Gly Val Ala  Pro Phe Thr 
    1355                 1360                 1365             


Ile Ala  Arg Asn Ala Asp Gln  Glu Glu Leu Val Lys  Ile Ser Leu 
    1370                 1375                 1380             


Ser Pro  Glu Tyr Val Phe Ser  Val Ser Thr Phe Arg  Glu Leu Pro 
    1385                 1390                 1395             


Ser Leu  Glu Gln Lys Leu Leu  Thr Pro Ile Thr Thr  Leu Thr Ser 
    1400                 1405                 1410             


Glu Gln  Ile Gln Lys Leu Leu  Ala Ser Thr Arg Tyr  Pro Pro Pro 
    1415                 1420                 1425             


Ala Val  Glu Ser Asp Ala Ala  Asp Ile Val Phe Leu  Ile Asp Ser 
    1430                 1435                 1440             


Ser Glu  Gly Val Arg Pro Asp  Gly Phe Ala His Ile  Arg Asp Phe 
    1445                 1450                 1455             


Val Ser  Arg Ile Val Arg Arg  Leu Asn Ile Gly Pro  Ser Lys Val 
    1460                 1465                 1470             


Arg Val  Gly Val Val Gln Phe  Ser Asn Asp Val Phe  Pro Glu Phe 
    1475                 1480                 1485             


Tyr Leu  Lys Thr Tyr Arg Ser  Gln Ala Pro Val Leu  Asp Ala Ile 
    1490                 1495                 1500             


Arg Arg  Leu Arg Leu Arg Gly  Gly Ser Pro Leu Asn  Thr Gly Lys 
    1505                 1510                 1515             


Ala Leu  Glu Phe Val Ala Arg  Asn Leu Phe Val Lys  Ser Ala Gly 
    1520                 1525                 1530             


Ser Arg  Ile Glu Asp Gly Val  Pro Gln His Leu Val  Leu Val Leu 
    1535                 1540                 1545             


Gly Gly  Lys Ser Gln Asp Asp  Val Ser Arg Phe Ala  Gln Val Ile 
    1550                 1555                 1560             


Arg Ser  Ser Gly Ile Val Ser  Leu Gly Val Gly Asp  Arg Asn Ile 
    1565                 1570                 1575             


Asp Arg  Thr Glu Leu Gln Thr  Ile Thr Asn Asp Pro  Arg Leu Val 
    1580                 1585                 1590             


Phe Thr  Val Arg Glu Phe Arg  Glu Leu Pro Asn Ile  Glu Glu Arg 
    1595                 1600                 1605             


Ile Met  Asn Ser Phe Gly Pro  Ser Ala Ala Thr Pro  Ala Pro Pro 
    1610                 1615                 1620             


Gly Val  Asp Thr Pro Pro Pro  Ser Arg Pro Glu Lys  Lys Lys Ala 
    1625                 1630                 1635             


Asp Ile  Val Phe Leu Leu Asp  Gly Ser Ile Asn Phe  Arg Arg Asp 
    1640                 1645                 1650             


Ser Phe  Gln Glu Val Leu Arg  Phe Val Ser Glu Ile  Val Asp Thr 
    1655                 1660                 1665             


Val Tyr  Glu Asp Gly Asp Ser  Ile Gln Val Gly Leu  Val Gln Tyr 
    1670                 1675                 1680             


Asn Ser  Asp Pro Thr Asp Glu  Phe Phe Leu Lys Asp  Phe Ser Thr 
    1685                 1690                 1695             


Lys Arg  Gln Ile Ile Asp Ala  Ile Asn Lys Val Val  Tyr Lys Gly 
    1700                 1705                 1710             


Gly Arg  His Ala Asn Thr Lys  Val Gly Leu Glu His  Leu Arg Val 
    1715                 1720                 1725             


Asn His  Phe Val Pro Glu Ala  Gly Ser Arg Leu Asp  Gln Arg Val 
    1730                 1735                 1740             


Pro Gln  Ile Ala Phe Val Ile  Thr Gly Gly Lys Ser  Val Glu Asp 
    1745                 1750                 1755             


Ala Gln  Asp Val Ser Leu Ala  Leu Thr Gln Arg Gly  Val Lys Val 
    1760                 1765                 1770             


Phe Ala  Val Gly Val Arg Asn  Ile Asp Ser Glu Glu  Val Gly Lys 
    1775                 1780                 1785             


Ile Ala  Ser Asn Ser Ala Thr  Ala Phe Arg Val Gly  Asn Val Gln 
    1790                 1795                 1800             


Glu Leu  Ser Glu Leu Ser Glu  Gln Val Leu Glu Thr  Leu His Asp 
    1805                 1810                 1815             


Ala Met  His Glu Thr Leu Cys  Pro Gly Val Thr Asp  Ala Ala Lys 
    1820                 1825                 1830             


Ala Cys  Asn Leu Asp Val Ile  Leu Gly Phe Asp Gly  Ser Arg Asp 
    1835                 1840                 1845             


Gln Asn  Val Phe Val Ala Gln  Lys Gly Phe Glu Ser  Lys Val Asp 
    1850                 1855                 1860             


Ala Ile  Leu Asn Arg Ile Ser  Gln Met His Arg Val  Ser Cys Ser 
    1865                 1870                 1875             


Gly Gly  Arg Ser Pro Thr Val  Arg Val Ser Val Val  Ala Asn Thr 
    1880                 1885                 1890             


Pro Ser  Gly Pro Val Glu Ala  Phe Asp Phe Asp Glu  Tyr Gln Pro 
    1895                 1900                 1905             


Glu Met  Leu Glu Lys Phe Arg  Asn Met Arg Ser Gln  His Pro Tyr 
    1910                 1915                 1920             


Val Leu  Thr Glu Asp Thr Leu  Lys Val Tyr Leu Asn  Lys Phe Arg 
    1925                 1930                 1935             


Gln Ser  Ser Pro Asp Ser Val  Lys Val Val Ile His  Phe Thr Asp 
    1940                 1945                 1950             


Gly Ala  Asp Gly Asp Leu Ala  Asp Leu His Arg Ala  Ser Glu Asn 
    1955                 1960                 1965             


Leu Arg  Gln Glu Gly Val Arg  Ala Leu Ile Leu Val  Gly Leu Glu 
    1970                 1975                 1980             


Arg Val  Val Asn Leu Glu Arg  Leu Met His Leu Glu  Phe Gly Arg 
    1985                 1990                 1995             


Gly Phe  Met Tyr Asp Arg Pro  Leu Arg Leu Asn Leu  Leu Asp Leu 
    2000                 2005                 2010             


Asp Tyr  Glu Leu Ala Glu Gln  Leu Asp Asn Ile Ala  Glu Lys Ala 
    2015                 2020                 2025             


Cys Cys  Gly Val Pro Cys Lys  Cys Ser Gly Gln Arg  Gly Asp Arg 
    2030                 2035                 2040             


Gly Pro  Ile Gly Ser Ile Gly  Pro Lys Gly Ile Pro  Gly Glu Asp 
    2045                 2050                 2055             


Gly Tyr  Arg Gly Tyr Pro Gly  Asp Glu Gly Gly Pro  Gly Glu Arg 
    2060                 2065                 2070             


Gly Pro  Pro Gly Val Asn Gly  Thr Gln Gly Phe Gln  Gly Cys Pro 
    2075                 2080                 2085             


Gly Gln  Arg Gly Val Lys Gly  Ser Arg Gly Phe Pro  Gly Glu Lys 
    2090                 2095                 2100             


Gly Glu  Val Gly Glu Ile Gly  Leu Asp Gly Leu Asp  Gly Glu Asp 
    2105                 2110                 2115             


Gly Asp  Lys Gly Leu Pro Gly  Ser Ser Gly Glu Lys  Gly Asn Pro 
    2120                 2125                 2130             


Gly Arg  Arg Gly Asp Lys Gly  Pro Arg Gly Glu Lys  Gly Glu Arg 
    2135                 2140                 2145             


Gly Asp  Val Gly Ile Arg Gly  Asp Pro Gly Asn Pro  Gly Gln Asp 
    2150                 2155                 2160             


Ser Gln  Glu Arg Gly Pro Lys  Gly Glu Thr Gly Asp  Leu Gly Pro 
    2165                 2170                 2175             


Met Gly  Val Pro Gly Arg Asp  Gly Val Pro Gly Gly  Pro Gly Glu 
    2180                 2185                 2190             


Thr Gly  Lys Asn Gly Gly Phe  Gly Arg Arg Gly Pro  Pro Gly Ala 
    2195                 2200                 2205             


Lys Gly  Asn Lys Gly Gly Pro  Gly Gln Pro Gly Phe  Glu Gly Glu 
    2210                 2215                 2220             


Gln Gly  Thr Arg Gly Ala Gln  Gly Pro Ala Gly Pro  Ala Gly Pro 
    2225                 2230                 2235             


Pro Gly  Leu Ile Gly Glu Gln  Gly Ile Ser Gly Pro  Arg Gly Ser 
    2240                 2245                 2250             


Gly Gly  Ala Ala Gly Ala Pro  Gly Glu Arg Gly Arg  Thr Gly Pro 
    2255                 2260                 2265             


Leu Gly  Arg Lys Gly Glu Pro  Gly Glu Pro Gly Pro  Lys Gly Gly 
    2270                 2275                 2280             


Ile Gly  Asn Arg Gly Pro Arg  Gly Glu Thr Gly Asp  Asp Gly Arg 
    2285                 2290                 2295             


Asp Gly  Val Gly Ser Glu Gly  Arg Arg Gly Lys Lys  Gly Glu Arg 
    2300                 2305                 2310             


Gly Phe  Pro Gly Tyr Pro Gly  Pro Lys Gly Asn Pro  Gly Glu Pro 
    2315                 2320                 2325             


Gly Leu  Asn Gly Thr Thr Gly  Pro Lys Gly Ile Arg  Gly Arg Arg 
    2330                 2335                 2340             


Gly Asn  Ser Gly Pro Pro Gly  Ile Val Gly Gln Lys  Gly Asp Pro 
    2345                 2350                 2355             


Gly Tyr  Pro Gly Pro Ala Gly  Pro Lys Gly Asn Arg  Gly Asp Ser 
    2360                 2365                 2370             


Ile Asp  Gln Cys Ala Leu Ile  Gln Ser Ile Lys Asp  Lys Cys Pro 
    2375                 2380                 2385             


Cys Cys  Tyr Gly Pro Leu Glu  Cys Pro Val Phe Pro  Thr Glu Leu 
    2390                 2395                 2400             


Ala Phe  Ala Leu Asp Thr Ser  Glu Gly Val Asn Gln  Asp Thr Phe 
    2405                 2410                 2415             


Gly Arg  Met Arg Asp Val Val  Leu Ser Ile Val Asn  Asp Leu Thr 
    2420                 2425                 2430             


Ile Ala  Glu Ser Asn Cys Pro  Arg Gly Ala Arg Val  Ala Val Val 
    2435                 2440                 2445             


Thr Tyr  Asn Asn Glu Val Thr  Thr Glu Ile Arg Phe  Ala Asp Ser 
    2450                 2455                 2460             


Lys Arg  Lys Ser Val Leu Leu  Asp Lys Ile Lys Asn  Leu Gln Val 
    2465                 2470                 2475             


Ala Leu  Thr Ser Lys Gln Gln  Ser Leu Glu Thr Ala  Met Ser Phe 
    2480                 2485                 2490             


Val Ala  Arg Asn Thr Phe Lys  Arg Val Arg Asn Gly  Phe Leu Met 
    2495                 2500                 2505             


Arg Lys  Val Ala Val Phe Phe  Ser Asn Thr Pro Thr  Arg Ala Ser 
    2510                 2515                 2520             


Pro Gln  Leu Arg Glu Ala Val  Leu Lys Leu Ser Asp  Ala Gly Ile 
    2525                 2530                 2535             


Thr Pro  Leu Phe Leu Thr Arg  Gln Glu Asp Arg Gln  Leu Ile Asn 
    2540                 2545                 2550             


Ala Leu  Gln Ile Asn Asn Thr  Ala Val Gly His Ala  Leu Val Leu 
    2555                 2560                 2565             


Pro Ala  Gly Arg Asp Leu Thr  Asp Phe Leu Glu Asn  Val Leu Thr 
    2570                 2575                 2580             


Cys His  Val Cys Leu Asp Ile  Cys Asn Ile Asp Pro  Ser Cys Gly 
    2585                 2590                 2595             


Phe Gly  Ser Trp Arg Pro Ser  Phe Arg Asp Arg Arg  Ala Ala Gly 
    2600                 2605                 2610             


Ser Asp  Val Asp Ile Asp Met  Ala Phe Ile Leu Asp  Ser Ala Glu 
    2615                 2620                 2625             


Thr Thr  Thr Leu Phe Gln Phe  Asn Glu Met Lys Lys  Tyr Ile Ala 
    2630                 2635                 2640             


Tyr Leu  Val Arg Gln Leu Asp  Met Ser Pro Asp Pro  Lys Ala Ser 
    2645                 2650                 2655             


Gln His  Phe Ala Arg Val Ala  Val Val Gln His Ala  Pro Ser Glu 
    2660                 2665                 2670             


Ser Val  Asp Asn Ala Ser Met  Pro Pro Val Lys Val  Glu Phe Ser 
    2675                 2680                 2685             


Leu Thr  Asp Tyr Gly Ser Lys  Glu Lys Leu Val Asp  Phe Leu Ser 
    2690                 2695                 2700             


Arg Gly  Met Thr Gln Leu Gln  Gly Thr Arg Ala Leu  Gly Ser Ala 
    2705                 2710                 2715             


Ile Glu  Tyr Thr Ile Glu Asn  Val Phe Glu Ser Ala  Pro Asn Pro 
    2720                 2725                 2730             


Arg Asp  Leu Lys Ile Val Val  Leu Met Leu Thr Gly  Glu Val Pro 
    2735                 2740                 2745             


Glu Gln  Gln Leu Glu Glu Ala  Gln Arg Val Ile Leu  Gln Ala Lys 
    2750                 2755                 2760             


Cys Lys  Gly Tyr Phe Phe Val  Val Leu Gly Ile Gly  Arg Lys Val 
    2765                 2770                 2775             


Asn Ile  Lys Glu Val Tyr Thr  Phe Ala Ser Glu Pro  Asn Asp Val 
    2780                 2785                 2790             


Phe Phe  Lys Leu Val Asp Lys  Ser Thr Glu Leu Asn  Glu Glu Pro 
    2795                 2800                 2805             


Leu Met  Arg Phe Gly Arg Leu  Leu Pro Ser Phe Val  Ser Ser Glu 
    2810                 2815                 2820             


Asn Ala  Phe Tyr Leu Ser Pro  Asp Ile Arg Lys Gln  Cys Asp Trp 
    2825                 2830                 2835             


Phe Gln  Gly Asp Gln Pro Thr  Lys Asn Leu Val Lys  Phe Gly His 
    2840                 2845                 2850             


Lys Gln  Val Asn Val Pro Asn  Asn Val Thr Ser Ser  Pro Thr Ser 
    2855                 2860                 2865             


Asn Pro  Val Thr Thr Thr Lys  Pro Val Thr Thr Thr  Lys Pro Val 
    2870                 2875                 2880             


Thr Thr  Thr Thr Lys Pro Val  Thr Thr Thr Thr Lys  Pro Val Thr 
    2885                 2890                 2895             


Ile Ile  Asn Gln Pro Ser Val  Lys Pro Ala Ala Ala  Lys Pro Ala 
    2900                 2905                 2910             


Pro Ala  Lys Pro Val Ala Ala  Lys Pro Val Ala Thr  Lys Met Ala 
    2915                 2920                 2925             


Thr Val  Arg Pro Pro Val Ala  Val Lys Pro Ala Thr  Ala Ala Lys 
    2930                 2935                 2940             


Pro Val  Ala Ala Lys Pro Ala  Ala Val Arg Pro Pro  Ala Ala Ala 
    2945                 2950                 2955             


Ala Ala  Lys Pro Val Ala Thr  Lys Pro Glu Val Pro  Arg Pro Gln 
    2960                 2965                 2970             


Ala Ala  Lys Pro Ala Ala Thr  Lys Pro Ala Thr Thr  Lys Pro Met 
    2975                 2980                 2985             


Val Lys  Met Ser Arg Glu Val  Gln Val Phe Glu Ile  Thr Glu Asn 
    2990                 2995                 3000             


Ser Ala  Lys Leu His Trp Glu  Arg Ala Glu Pro Pro  Gly Pro Tyr 
    3005                 3010                 3015             


Phe Tyr  Asp Leu Thr Val Thr  Ser Ala His Asp Gln  Ser Leu Val 
    3020                 3025                 3030             


Leu Lys  Gln Asn Leu Thr Val  Thr Asp Arg Val Ile  Gly Gly Leu 
    3035                 3040                 3045             


Leu Ala  Gly Gln Thr Tyr His  Val Ala Val Val Cys  Tyr Leu Arg 
    3050                 3055                 3060             


Ser Gln  Val Arg Ala Thr Tyr  His Gly Ser Phe Ser  Thr Lys Lys 
    3065                 3070                 3075             


Ser Gln  Pro Pro Pro Pro Gln  Pro Ala Arg Ser Ala  Ser Ser Ser 
    3080                 3085                 3090             


Thr Ile  Asn Leu Met Val Ser  Thr Glu Pro Leu Ala  Leu Thr Glu 
    3095                 3100                 3105             


Thr Asp  Ile Cys Lys Leu Pro  Lys Asp Glu Gly Thr  Cys Arg Asp 
    3110                 3115                 3120             


Phe Ile  Leu Lys Trp Tyr Tyr  Asp Pro Asn Thr Lys  Ser Cys Ala 
    3125                 3130                 3135             


Arg Phe  Trp Tyr Gly Gly Cys  Gly Gly Asn Glu Asn  Lys Phe Gly 
    3140                 3145                 3150             


Ser Gln  Lys Glu Cys Glu Lys  Val Cys Ala Pro Val  Leu Ala Lys 
    3155                 3160                 3165             


Pro Gly  Val Ile Ser Val Met  Gly Thr 
    3170                 3175         


<210>  3333
<211>  708
<212>  PRT
<213>  Homo Sapiens

<400>  3333

Met Arg Lys His Arg His Leu Pro Leu Val Ala Val Phe Cys Leu Phe 
1               5                   10                  15      


Leu Ser Gly Phe Pro Thr Thr His Ala Gln Gln Gln Gln Ala Asp Val 
            20                  25                  30          


Lys Asn Gly Ala Ala Ala Asp Ile Ile Phe Leu Val Asp Ser Ser Trp 
        35                  40                  45              


Thr Ile Gly Glu Glu His Phe Gln Leu Val Arg Glu Phe Leu Tyr Asp 
    50                  55                  60                  


Val Val Lys Ser Leu Ala Val Gly Glu Asn Asp Phe His Phe Ala Leu 
65                  70                  75                  80  


Val Gln Phe Asn Gly Asn Pro His Thr Glu Phe Leu Leu Asn Thr Tyr 
                85                  90                  95      


Arg Thr Lys Gln Glu Val Leu Ser His Ile Ser Asn Met Ser Tyr Ile 
            100                 105                 110         


Gly Gly Thr Asn Gln Thr Gly Lys Gly Leu Glu Tyr Ile Met Gln Ser 
        115                 120                 125             


His Leu Thr Lys Ala Ala Gly Ser Arg Ala Gly Asp Gly Val Pro Gln 
    130                 135                 140                 


Val Ile Val Val Leu Thr Asp Gly His Ser Lys Asp Gly Leu Ala Leu 
145                 150                 155                 160 


Pro Ser Ala Glu Leu Lys Ser Ala Asp Val Asn Val Phe Ala Ile Gly 
                165                 170                 175     


Val Glu Asp Ala Asp Glu Gly Ala Leu Lys Glu Ile Ala Ser Glu Pro 
            180                 185                 190         


Leu Asn Met His Met Phe Asn Leu Glu Asn Phe Thr Ser Leu His Asp 
        195                 200                 205             


Ile Val Gly Asn Leu Val Ser Cys Val His Ser Ser Val Ser Pro Glu 
    210                 215                 220                 


Arg Ala Gly Asp Thr Glu Thr Leu Lys Asp Ile Thr Ala Gln Asp Ser 
225                 230                 235                 240 


Ala Asp Ile Ile Phe Leu Ile Asp Gly Ser Asn Asn Thr Gly Ser Val 
                245                 250                 255     


Asn Phe Ala Val Ile Leu Asp Phe Leu Val Asn Leu Leu Glu Lys Leu 
            260                 265                 270         


Pro Ile Gly Thr Gln Gln Ile Arg Val Gly Val Val Gln Phe Ser Asp 
        275                 280                 285             


Glu Pro Arg Thr Met Phe Ser Leu Asp Thr Tyr Ser Thr Lys Ala Gln 
    290                 295                 300                 


Val Leu Gly Ala Val Lys Ala Leu Gly Phe Ala Gly Gly Glu Leu Ala 
305                 310                 315                 320 


Asn Ile Gly Leu Ala Leu Asp Phe Val Val Glu Asn His Phe Thr Arg 
                325                 330                 335     


Ala Gly Gly Ser Arg Val Glu Glu Gly Val Pro Gln Val Leu Val Leu 
            340                 345                 350         


Ile Ser Ala Gly Pro Ser Ser Asp Glu Ile Arg Tyr Gly Val Val Ala 
        355                 360                 365             


Leu Lys Gln Ala Ser Val Phe Ser Phe Gly Leu Gly Ala Gln Ala Ala 
    370                 375                 380                 


Ser Arg Ala Glu Leu Gln His Ile Ala Thr Asp Asp Asn Leu Val Phe 
385                 390                 395                 400 


Thr Val Pro Glu Phe Arg Ser Phe Gly Asp Leu Gln Glu Lys Leu Leu 
                405                 410                 415     


Pro Tyr Ile Val Gly Val Ala Gln Arg His Ile Val Leu Lys Pro Pro 
            420                 425                 430         


Thr Ile Val Thr Gln Val Ile Glu Val Asn Lys Arg Asp Ile Val Phe 
        435                 440                 445             


Leu Val Asp Gly Ser Ser Ala Leu Gly Leu Ala Asn Phe Asn Ala Ile 
    450                 455                 460                 


Arg Asp Phe Ile Ala Lys Val Ile Gln Arg Leu Glu Ile Gly Gln Asp 
465                 470                 475                 480 


Leu Ile Gln Val Ala Val Ala Gln Tyr Ala Asp Thr Val Arg Pro Glu 
                485                 490                 495     


Phe Tyr Phe Asn Thr His Pro Thr Lys Arg Glu Val Ile Thr Ala Val 
            500                 505                 510         


Arg Lys Met Lys Pro Leu Asp Gly Ser Ala Leu Tyr Thr Gly Ser Ala 
        515                 520                 525             


Leu Asp Phe Val Arg Asn Asn Leu Phe Thr Ser Ser Ala Gly Tyr Arg 
    530                 535                 540                 


Ala Ala Glu Gly Ile Pro Lys Leu Leu Val Leu Ile Thr Gly Gly Lys 
545                 550                 555                 560 


Ser Leu Asp Glu Ile Ser Gln Pro Ala Gln Glu Leu Lys Arg Ser Ser 
                565                 570                 575     


Ile Met Ala Phe Ala Ile Gly Asn Lys Gly Ala Asp Gln Ala Glu Leu 
            580                 585                 590         


Glu Glu Ile Ala Phe Asp Ser Ser Leu Val Phe Ile Pro Ala Glu Phe 
        595                 600                 605             


Arg Ala Ala Pro Leu Gln Gly Met Leu Pro Gly Leu Leu Ala Pro Leu 
    610                 615                 620                 


Arg Thr Leu Ser Gly Thr Pro Glu Glu Ser Lys Arg Asp Ile Leu Phe 
625                 630                 635                 640 


Leu Phe Asp Gly Ser Ala Asn Leu Val Gly Gln Phe Pro Val Val Arg 
                645                 650                 655     


Asp Phe Leu Tyr Lys Ile Ile Asp Glu Leu Asn Val Lys Pro Glu Gly 
            660                 665                 670         


Thr Arg Ile Ala Val Ala Gln Tyr Ser Asp Asp Val Lys Val Glu Ser 
        675                 680                 685             


Arg Phe Asp Glu His Gln Ser Lys Pro Glu Ile Leu Asn Leu Val Lys 
    690                 695                 700                 


Arg Met Lys Ile 
705             


<210>  3334
<211>  2569
<212>  PRT
<213>  Homo Sapiens

<400>  3334

Met Arg Lys His Arg His Leu Pro Leu Val Ala Val Phe Cys Leu Phe 
1               5                   10                  15      


Leu Ser Gly Phe Pro Thr Thr His Ala Gln Gln Gln Gln Ala Val Ile 
            20                  25                  30          


Glu Val Asn Lys Arg Asp Ile Val Phe Leu Val Asp Gly Ser Ser Ala 
        35                  40                  45              


Leu Gly Leu Ala Asn Phe Asn Ala Ile Arg Asp Phe Ile Ala Lys Val 
    50                  55                  60                  


Ile Gln Arg Leu Glu Ile Gly Gln Asp Leu Ile Gln Val Ala Val Ala 
65                  70                  75                  80  


Gln Tyr Ala Asp Thr Val Arg Pro Glu Phe Tyr Phe Asn Thr His Pro 
                85                  90                  95      


Thr Lys Arg Glu Val Ile Thr Ala Val Arg Lys Met Lys Pro Leu Asp 
            100                 105                 110         


Gly Ser Ala Leu Tyr Thr Gly Ser Ala Leu Asp Phe Val Arg Asn Asn 
        115                 120                 125             


Leu Phe Thr Ser Ser Ala Gly Tyr Arg Ala Ala Glu Gly Ile Pro Lys 
    130                 135                 140                 


Leu Leu Val Leu Ile Thr Gly Gly Lys Ser Leu Asp Glu Ile Ser Gln 
145                 150                 155                 160 


Pro Ala Gln Glu Leu Lys Arg Ser Ser Ile Met Ala Phe Ala Ile Gly 
                165                 170                 175     


Asn Lys Gly Ala Asp Gln Ala Glu Leu Glu Glu Ile Ala Phe Asp Ser 
            180                 185                 190         


Ser Leu Val Phe Ile Pro Ala Glu Phe Arg Ala Ala Pro Leu Gln Gly 
        195                 200                 205             


Met Leu Pro Gly Leu Leu Ala Pro Leu Arg Thr Leu Ser Gly Thr Pro 
    210                 215                 220                 


Glu Glu Ser Lys Arg Asp Ile Leu Phe Leu Phe Asp Gly Ser Ala Asn 
225                 230                 235                 240 


Leu Val Gly Gln Phe Pro Val Val Arg Asp Phe Leu Tyr Lys Ile Ile 
                245                 250                 255     


Asp Glu Leu Asn Val Lys Pro Glu Gly Thr Arg Ile Ala Val Ala Gln 
            260                 265                 270         


Tyr Ser Asp Asp Val Lys Val Glu Ser Arg Phe Asp Glu His Gln Ser 
        275                 280                 285             


Lys Pro Glu Ile Leu Asn Leu Val Lys Arg Met Lys Ile Lys Thr Gly 
    290                 295                 300                 


Lys Ala Leu Asn Leu Gly Tyr Ala Leu Asp Tyr Ala Gln Arg Tyr Ile 
305                 310                 315                 320 


Phe Val Lys Ser Ala Gly Ser Arg Ile Glu Asp Gly Val Leu Gln Phe 
                325                 330                 335     


Leu Val Leu Leu Val Ala Gly Arg Ser Ser Asp Arg Val Asp Gly Pro 
            340                 345                 350         


Ala Ser Asn Leu Lys Gln Ser Gly Val Val Pro Phe Ile Phe Gln Ala 
        355                 360                 365             


Lys Asn Ala Asp Pro Ala Glu Leu Glu Gln Ile Val Leu Ser Pro Ala 
    370                 375                 380                 


Phe Ile Leu Ala Ala Glu Ser Leu Pro Lys Ile Gly Asp Leu His Pro 
385                 390                 395                 400 


Gln Ile Val Asn Leu Leu Lys Ser Val His Asn Gly Ala Pro Ala Pro 
                405                 410                 415     


Val Ser Gly Glu Lys Asp Val Val Phe Leu Leu Asp Gly Ser Glu Gly 
            420                 425                 430         


Val Arg Ser Gly Phe Pro Leu Leu Lys Glu Phe Val Gln Arg Val Val 
        435                 440                 445             


Glu Ser Leu Asp Val Gly Gln Asp Arg Val Arg Val Ala Val Val Gln 
    450                 455                 460                 


Tyr Ser Asp Arg Thr Arg Pro Glu Phe Tyr Leu Asn Ser Tyr Met Asn 
465                 470                 475                 480 


Lys Gln Asp Val Val Asn Ala Val Arg Gln Leu Thr Leu Leu Gly Gly 
                485                 490                 495     


Pro Thr Pro Asn Thr Gly Ala Ala Leu Glu Phe Val Leu Arg Asn Ile 
            500                 505                 510         


Leu Val Ser Ser Ala Gly Ser Arg Ile Thr Glu Gly Val Pro Gln Leu 
        515                 520                 525             


Leu Ile Val Leu Thr Ala Asp Arg Ser Gly Asp Asp Val Arg Asn Pro 
    530                 535                 540                 


Ser Val Val Val Lys Arg Gly Gly Ala Val Pro Ile Gly Ile Gly Ile 
545                 550                 555                 560 


Gly Asn Ala Asp Ile Thr Glu Met Gln Thr Ile Ser Phe Ile Pro Asp 
                565                 570                 575     


Phe Ala Val Ala Ile Pro Thr Phe Arg Gln Leu Gly Thr Val Gln Gln 
            580                 585                 590         


Val Ile Ser Glu Arg Val Thr Gln Leu Thr Arg Glu Glu Leu Ser Arg 
        595                 600                 605             


Leu Gln Pro Val Leu Gln Pro Leu Pro Ser Pro Gly Val Gly Gly Lys 
    610                 615                 620                 


Arg Asp Val Val Phe Leu Ile Asp Gly Ser Gln Ser Ala Gly Pro Glu 
625                 630                 635                 640 


Phe Gln Tyr Val Arg Thr Leu Ile Glu Arg Leu Val Asp Tyr Leu Asp 
                645                 650                 655     


Val Gly Phe Asp Thr Thr Arg Val Ala Val Ile Gln Phe Ser Asp Asp 
            660                 665                 670         


Pro Lys Val Glu Phe Leu Leu Asn Ala His Ser Ser Lys Asp Glu Val 
        675                 680                 685             


Gln Asn Ala Val Gln Arg Leu Arg Pro Lys Gly Gly Arg Gln Ile Asn 
    690                 695                 700                 


Val Gly Asn Ala Leu Glu Tyr Val Ser Arg Asn Ile Phe Lys Arg Pro 
705                 710                 715                 720 


Leu Gly Ser Arg Ile Glu Glu Gly Val Pro Gln Phe Leu Val Leu Ile 
                725                 730                 735     


Ser Ser Gly Lys Ser Asp Asp Glu Val Asp Asp Pro Ala Val Glu Leu 
            740                 745                 750         


Lys Gln Phe Gly Val Ala Pro Phe Thr Ile Ala Arg Asn Ala Asp Gln 
        755                 760                 765             


Glu Glu Leu Val Lys Ile Ser Leu Ser Pro Glu Tyr Val Phe Ser Val 
    770                 775                 780                 


Ser Thr Phe Arg Glu Leu Pro Ser Leu Glu Gln Lys Leu Leu Thr Pro 
785                 790                 795                 800 


Ile Thr Thr Leu Thr Ser Glu Gln Ile Gln Lys Leu Leu Ala Ser Thr 
                805                 810                 815     


Arg Tyr Pro Pro Pro Ala Val Glu Ser Asp Ala Ala Asp Ile Val Phe 
            820                 825                 830         


Leu Ile Asp Ser Ser Glu Gly Val Arg Pro Asp Gly Phe Ala His Ile 
        835                 840                 845             


Arg Asp Phe Val Ser Arg Ile Val Arg Arg Leu Asn Ile Gly Pro Ser 
    850                 855                 860                 


Lys Val Arg Val Gly Val Val Gln Phe Ser Asn Asp Val Phe Pro Glu 
865                 870                 875                 880 


Phe Tyr Leu Lys Thr Tyr Arg Ser Gln Ala Pro Val Leu Asp Ala Ile 
                885                 890                 895     


Arg Arg Leu Arg Leu Arg Gly Gly Ser Pro Leu Asn Thr Gly Lys Ala 
            900                 905                 910         


Leu Glu Phe Val Ala Arg Asn Leu Phe Val Lys Ser Ala Gly Ser Arg 
        915                 920                 925             


Ile Glu Asp Gly Val Pro Gln His Leu Val Leu Val Leu Gly Gly Lys 
    930                 935                 940                 


Ser Gln Asp Asp Val Ser Arg Phe Ala Gln Val Ile Arg Ser Ser Gly 
945                 950                 955                 960 


Ile Val Ser Leu Gly Val Gly Asp Arg Asn Ile Asp Arg Thr Glu Leu 
                965                 970                 975     


Gln Thr Ile Thr Asn Asp Pro Arg Leu Val Phe Thr Val Arg Glu Phe 
            980                 985                 990         


Arg Glu Leu Pro Asn Ile Glu Glu  Arg Ile Met Asn Ser  Phe Gly Pro 
        995                 1000                 1005             


Ser Ala  Ala Thr Pro Ala Pro  Pro Gly Val Asp Thr  Pro Pro Pro 
    1010                 1015                 1020             


Ser Arg  Pro Glu Lys Lys Lys  Ala Asp Ile Val Phe  Leu Leu Asp 
    1025                 1030                 1035             


Gly Ser  Ile Asn Phe Arg Arg  Asp Ser Phe Gln Glu  Val Leu Arg 
    1040                 1045                 1050             


Phe Val  Ser Glu Ile Val Asp  Thr Val Tyr Glu Asp  Gly Asp Ser 
    1055                 1060                 1065             


Ile Gln  Val Gly Leu Val Gln  Tyr Asn Ser Asp Pro  Thr Asp Glu 
    1070                 1075                 1080             


Phe Phe  Leu Lys Asp Phe Ser  Thr Lys Arg Gln Ile  Ile Asp Ala 
    1085                 1090                 1095             


Ile Asn  Lys Val Val Tyr Lys  Gly Gly Arg His Ala  Asn Thr Lys 
    1100                 1105                 1110             


Val Gly  Leu Glu His Leu Arg  Val Asn His Phe Val  Pro Glu Ala 
    1115                 1120                 1125             


Gly Ser  Arg Leu Asp Gln Arg  Val Pro Gln Ile Ala  Phe Val Ile 
    1130                 1135                 1140             


Thr Gly  Gly Lys Ser Val Glu  Asp Ala Gln Asp Val  Ser Leu Ala 
    1145                 1150                 1155             


Leu Thr  Gln Arg Gly Val Lys  Val Phe Ala Val Gly  Val Arg Asn 
    1160                 1165                 1170             


Ile Asp  Ser Glu Glu Val Gly  Lys Ile Ala Ser Asn  Ser Ala Thr 
    1175                 1180                 1185             


Ala Phe  Arg Val Gly Asn Val  Gln Glu Leu Ser Glu  Leu Ser Glu 
    1190                 1195                 1200             


Gln Val  Leu Glu Thr Leu His  Asp Ala Met His Glu  Thr Leu Cys 
    1205                 1210                 1215             


Pro Gly  Val Thr Asp Ala Ala  Lys Ala Cys Asn Leu  Asp Val Ile 
    1220                 1225                 1230             


Leu Gly  Phe Asp Gly Ser Arg  Asp Gln Asn Val Phe  Val Ala Gln 
    1235                 1240                 1245             


Lys Gly  Phe Glu Ser Lys Val  Asp Ala Ile Leu Asn  Arg Ile Ser 
    1250                 1255                 1260             


Gln Met  His Arg Val Ser Cys  Ser Gly Gly Arg Ser  Pro Thr Val 
    1265                 1270                 1275             


Arg Val  Ser Val Val Ala Asn  Thr Pro Ser Gly Pro  Val Glu Ala 
    1280                 1285                 1290             


Phe Asp  Phe Asp Glu Tyr Gln  Pro Glu Met Leu Glu  Lys Phe Arg 
    1295                 1300                 1305             


Asn Met  Arg Ser Gln His Pro  Tyr Val Leu Thr Glu  Asp Thr Leu 
    1310                 1315                 1320             


Lys Val  Tyr Leu Asn Lys Phe  Arg Gln Ser Ser Pro  Asp Ser Val 
    1325                 1330                 1335             


Lys Val  Val Ile His Phe Thr  Asp Gly Ala Asp Gly  Asp Leu Ala 
    1340                 1345                 1350             


Asp Leu  His Arg Ala Ser Glu  Asn Leu Arg Gln Glu  Gly Val Arg 
    1355                 1360                 1365             


Ala Leu  Ile Leu Val Gly Leu  Glu Arg Val Val Asn  Leu Glu Arg 
    1370                 1375                 1380             


Leu Met  His Leu Glu Phe Gly  Arg Gly Phe Met Tyr  Asp Arg Pro 
    1385                 1390                 1395             


Leu Arg  Leu Asn Leu Leu Asp  Leu Asp Tyr Glu Leu  Ala Glu Gln 
    1400                 1405                 1410             


Leu Asp  Asn Ile Ala Glu Lys  Ala Cys Cys Gly Val  Pro Cys Lys 
    1415                 1420                 1425             


Cys Ser  Gly Gln Arg Gly Asp  Arg Gly Pro Ile Gly  Ser Ile Gly 
    1430                 1435                 1440             


Pro Lys  Gly Ile Pro Gly Glu  Asp Gly Tyr Arg Gly  Tyr Pro Gly 
    1445                 1450                 1455             


Asp Glu  Gly Gly Pro Gly Glu  Arg Gly Pro Pro Gly  Val Asn Gly 
    1460                 1465                 1470             


Thr Gln  Gly Phe Gln Gly Cys  Pro Gly Gln Arg Gly  Val Lys Gly 
    1475                 1480                 1485             


Ser Arg  Gly Phe Pro Gly Glu  Lys Gly Glu Val Gly  Glu Ile Gly 
    1490                 1495                 1500             


Leu Asp  Gly Leu Asp Gly Glu  Asp Gly Asp Lys Gly  Leu Pro Gly 
    1505                 1510                 1515             


Ser Ser  Gly Glu Lys Gly Asn  Pro Gly Arg Arg Gly  Asp Lys Gly 
    1520                 1525                 1530             


Pro Arg  Gly Glu Lys Gly Glu  Arg Gly Asp Val Gly  Ile Arg Gly 
    1535                 1540                 1545             


Asp Pro  Gly Asn Pro Gly Gln  Asp Ser Gln Glu Arg  Gly Pro Lys 
    1550                 1555                 1560             


Gly Glu  Thr Gly Asp Leu Gly  Pro Met Gly Val Pro  Gly Arg Asp 
    1565                 1570                 1575             


Gly Val  Pro Gly Gly Pro Gly  Glu Thr Gly Lys Asn  Gly Gly Phe 
    1580                 1585                 1590             


Gly Arg  Arg Gly Pro Pro Gly  Ala Lys Gly Asn Lys  Gly Gly Pro 
    1595                 1600                 1605             


Gly Gln  Pro Gly Phe Glu Gly  Glu Gln Gly Thr Arg  Gly Ala Gln 
    1610                 1615                 1620             


Gly Pro  Ala Gly Pro Ala Gly  Pro Pro Gly Leu Ile  Gly Glu Gln 
    1625                 1630                 1635             


Gly Ile  Ser Gly Pro Arg Gly  Ser Gly Gly Ala Ala  Gly Ala Pro 
    1640                 1645                 1650             


Gly Glu  Arg Gly Arg Thr Gly  Pro Leu Gly Arg Lys  Gly Glu Pro 
    1655                 1660                 1665             


Gly Glu  Pro Gly Pro Lys Gly  Gly Ile Gly Asn Arg  Gly Pro Arg 
    1670                 1675                 1680             


Gly Glu  Thr Gly Asp Asp Gly  Arg Asp Gly Val Gly  Ser Glu Gly 
    1685                 1690                 1695             


Arg Arg  Gly Lys Lys Gly Glu  Arg Gly Phe Pro Gly  Tyr Pro Gly 
    1700                 1705                 1710             


Pro Lys  Gly Asn Pro Gly Glu  Pro Gly Leu Asn Gly  Thr Thr Gly 
    1715                 1720                 1725             


Pro Lys  Gly Ile Arg Gly Arg  Arg Gly Asn Ser Gly  Pro Pro Gly 
    1730                 1735                 1740             


Ile Val  Gly Gln Lys Gly Asp  Pro Gly Tyr Pro Gly  Pro Ala Gly 
    1745                 1750                 1755             


Pro Lys  Gly Asn Arg Gly Asp  Ser Ile Asp Gln Cys  Ala Leu Ile 
    1760                 1765                 1770             


Gln Ser  Ile Lys Asp Lys Cys  Pro Phe His Gly Pro  Leu Glu Cys 
    1775                 1780                 1785             


Pro Val  Phe Pro Thr Glu Leu  Ala Phe Ala Leu Asp  Thr Ser Glu 
    1790                 1795                 1800             


Gly Val  Asn Gln Asp Thr Phe  Gly Arg Met Arg Asp  Val Val Leu 
    1805                 1810                 1815             


Ser Ile  Val Asn Asp Leu Thr  Ile Ala Glu Ser Asn  Cys Pro Arg 
    1820                 1825                 1830             


Gly Ala  Arg Val Ala Val Val  Thr Tyr Asn Asn Glu  Val Thr Thr 
    1835                 1840                 1845             


Glu Ile  Arg Phe Ala Asp Ser  Lys Arg Lys Ser Val  Leu Leu Asp 
    1850                 1855                 1860             


Lys Ile  Lys Asn Leu Gln Val  Ala Leu Thr Ser Lys  Gln Gln Ser 
    1865                 1870                 1875             


Leu Glu  Thr Ala Met Ser Phe  Val Ala Arg Asn Thr  Phe Lys Arg 
    1880                 1885                 1890             


Val Arg  Asn Gly Phe Leu Met  Arg Lys Val Ala Val  Phe Phe Ser 
    1895                 1900                 1905             


Asn Thr  Pro Thr Arg Ala Ser  Pro Gln Leu Arg Glu  Ala Val Leu 
    1910                 1915                 1920             


Lys Leu  Ser Asp Ala Gly Ile  Thr Pro Leu Phe Leu  Thr Arg Gln 
    1925                 1930                 1935             


Glu Asp  Arg Gln Leu Ile Asn  Ala Leu Gln Ile Asn  Asn Thr Ala 
    1940                 1945                 1950             


Val Gly  His Ala Leu Val Leu  Pro Ala Gly Arg Asp  Leu Thr Asp 
    1955                 1960                 1965             


Phe Leu  Glu Asn Val Leu Thr  Cys His Val Cys Leu  Asp Ile Cys 
    1970                 1975                 1980             


Asn Ile  Asp Pro Ser Cys Gly  Phe Gly Ser Trp Arg  Pro Ser Phe 
    1985                 1990                 1995             


Arg Asp  Arg Arg Ala Ala Gly  Ser Asp Val Asp Ile  Asp Met Ala 
    2000                 2005                 2010             


Phe Ile  Leu Asp Ser Ala Glu  Thr Thr Thr Leu Phe  Gln Phe Asn 
    2015                 2020                 2025             


Glu Met  Lys Lys Tyr Ile Ala  Tyr Leu Val Arg Gln  Leu Asp Met 
    2030                 2035                 2040             


Ser Pro  Asp Pro Lys Ala Ser  Gln His Phe Ala Arg  Val Ala Val 
    2045                 2050                 2055             


Val Gln  His Ala Pro Ser Glu  Ser Val Asp Asn Ala  Ser Met Pro 
    2060                 2065                 2070             


Pro Val  Lys Val Glu Phe Ser  Leu Thr Asp Tyr Gly  Ser Lys Glu 
    2075                 2080                 2085             


Lys Leu  Val Asp Phe Leu Ser  Arg Gly Met Thr Gln  Leu Gln Gly 
    2090                 2095                 2100             


Thr Arg  Ala Leu Gly Ser Ala  Ile Glu Tyr Thr Ile  Glu Asn Val 
    2105                 2110                 2115             


Phe Glu  Ser Ala Pro Asn Pro  Arg Asp Leu Lys Ile  Val Val Leu 
    2120                 2125                 2130             


Met Leu  Thr Gly Glu Val Pro  Glu Gln Gln Leu Glu  Glu Ala Gln 
    2135                 2140                 2145             


Arg Val  Ile Leu Gln Ala Lys  Cys Lys Gly Tyr Phe  Phe Val Val 
    2150                 2155                 2160             


Leu Gly  Ile Gly Arg Lys Val  Asn Ile Lys Glu Val  Tyr Thr Phe 
    2165                 2170                 2175             


Ala Ser  Glu Pro Asn Asp Val  Phe Phe Lys Leu Val  Asp Lys Ser 
    2180                 2185                 2190             


Thr Glu  Leu Asn Glu Glu Pro  Leu Met Arg Phe Gly  Arg Leu Leu 
    2195                 2200                 2205             


Pro Ser  Phe Val Ser Ser Glu  Asn Ala Phe Tyr Leu  Ser Pro Asp 
    2210                 2215                 2220             


Ile Arg  Lys Gln Cys Asp Trp  Phe Gln Gly Asp Gln  Pro Thr Lys 
    2225                 2230                 2235             


Asn Leu  Val Lys Phe Gly His  Lys Gln Val Asn Val  Pro Asn Asn 
    2240                 2245                 2250             


Val Thr  Ser Ser Pro Thr Ser  Asn Pro Val Thr Thr  Thr Lys Pro 
    2255                 2260                 2265             


Val Thr  Thr Thr Lys Pro Val  Thr Thr Thr Thr Lys  Pro Val Thr 
    2270                 2275                 2280             


Thr Thr  Thr Lys Pro Val Thr  Ile Ile Asn Gln Pro  Ser Val Lys 
    2285                 2290                 2295             


Pro Ala  Ala Ala Lys Pro Ala  Pro Ala Lys Pro Val  Ala Ala Lys 
    2300                 2305                 2310             


Pro Val  Ala Thr Lys Met Ala  Thr Val Arg Pro Pro  Val Ala Val 
    2315                 2320                 2325             


Lys Pro  Ala Thr Ala Ala Lys  Pro Val Ala Ala Lys  Pro Ala Ala 
    2330                 2335                 2340             


Val Arg  Pro Pro Ala Ala Ala  Ala Ala Lys Pro Val  Ala Thr Lys 
    2345                 2350                 2355             


Pro Glu  Val Pro Arg Pro Gln  Ala Ala Lys Pro Ala  Ala Thr Lys 
    2360                 2365                 2370             


Pro Ala  Thr Thr Lys Pro Met  Val Lys Met Ser Arg  Glu Val Gln 
    2375                 2380                 2385             


Val Phe  Glu Ile Thr Glu Asn  Ser Ala Lys Leu His  Trp Glu Arg 
    2390                 2395                 2400             


Ala Glu  Pro Pro Gly Pro Tyr  Phe Tyr Asp Leu Thr  Val Thr Ser 
    2405                 2410                 2415             


Ala His  Asp Gln Ser Leu Val  Leu Lys Gln Asn Leu  Thr Val Thr 
    2420                 2425                 2430             


Asp Arg  Val Ile Gly Gly Leu  Leu Ala Gly Gln Thr  Tyr His Val 
    2435                 2440                 2445             


Ala Val  Val Cys Tyr Leu Arg  Ser Gln Val Arg Ala  Thr Tyr His 
    2450                 2455                 2460             


Gly Ser  Phe Ser Thr Lys Lys  Ser Gln Pro Pro Pro  Pro Gln Pro 
    2465                 2470                 2475             


Ala Arg  Ser Ala Ser Ser Ser  Thr Ile Asn Leu Met  Val Ser Thr 
    2480                 2485                 2490             


Glu Pro  Leu Ala Leu Thr Glu  Thr Asp Ile Cys Lys  Leu Pro Lys 
    2495                 2500                 2505             


Asp Glu  Gly Thr Cys Arg Asp  Phe Ile Leu Lys Trp  Tyr Tyr Asp 
    2510                 2515                 2520             


Pro Asn  Thr Lys Ser Cys Ala  Arg Phe Trp Tyr Gly  Gly Cys Gly 
    2525                 2530                 2535             


Gly Asn  Glu Asn Lys Phe Gly  Ser Gln Lys Glu Cys  Glu Lys Val 
    2540                 2545                 2550             


Cys Ala  Pro Val Leu Ala Lys  Pro Gly Val Ile Ser  Val Met Gly 
    2555                 2560                 2565             


Thr 
    


<210>  3335
<211>  2570
<212>  PRT
<213>  Homo Sapiens

<400>  3335

Met Arg Lys His Arg His Leu Pro Leu Val Ala Val Phe Cys Leu Phe 
1               5                   10                  15      


Leu Ser Gly Phe Pro Thr Thr His Ala Gln Gln Gln Gln Ala Val Ile 
            20                  25                  30          


Glu Val Asn Lys Arg Asp Ile Val Phe Leu Val Asp Gly Ser Ser Ala 
        35                  40                  45              


Leu Gly Leu Ala Asn Phe Asn Ala Ile Arg Asp Phe Ile Ala Lys Val 
    50                  55                  60                  


Ile Gln Arg Leu Glu Ile Gly Gln Asp Leu Ile Gln Val Ala Val Ala 
65                  70                  75                  80  


Gln Tyr Ala Asp Thr Val Arg Pro Glu Phe Tyr Phe Asn Thr His Pro 
                85                  90                  95      


Thr Lys Arg Glu Val Ile Thr Ala Val Arg Lys Met Lys Pro Leu Asp 
            100                 105                 110         


Gly Ser Ala Leu Tyr Thr Gly Ser Ala Leu Asp Phe Val Arg Asn Asn 
        115                 120                 125             


Leu Phe Thr Ser Ser Ala Gly Tyr Arg Ala Ala Glu Gly Ile Pro Lys 
    130                 135                 140                 


Leu Leu Val Leu Ile Thr Gly Gly Lys Ser Leu Asp Glu Ile Ser Gln 
145                 150                 155                 160 


Pro Ala Gln Glu Leu Lys Arg Ser Ser Ile Met Ala Phe Ala Ile Gly 
                165                 170                 175     


Asn Lys Gly Ala Asp Gln Ala Glu Leu Glu Glu Ile Ala Phe Asp Ser 
            180                 185                 190         


Ser Leu Val Phe Ile Pro Ala Glu Phe Arg Ala Ala Pro Leu Gln Gly 
        195                 200                 205             


Met Leu Pro Gly Leu Leu Ala Pro Leu Arg Thr Leu Ser Gly Thr Pro 
    210                 215                 220                 


Glu Glu Ser Lys Arg Asp Ile Leu Phe Leu Phe Asp Gly Ser Ala Asn 
225                 230                 235                 240 


Leu Val Gly Gln Phe Pro Val Val Arg Asp Phe Leu Tyr Lys Ile Ile 
                245                 250                 255     


Asp Glu Leu Asn Val Lys Pro Glu Gly Thr Arg Ile Ala Val Ala Gln 
            260                 265                 270         


Tyr Ser Asp Asp Val Lys Val Glu Ser Arg Phe Asp Glu His Gln Ser 
        275                 280                 285             


Lys Pro Glu Ile Leu Asn Leu Val Lys Arg Met Lys Ile Lys Thr Gly 
    290                 295                 300                 


Lys Ala Leu Asn Leu Gly Tyr Ala Leu Asp Tyr Ala Gln Arg Tyr Ile 
305                 310                 315                 320 


Phe Val Lys Ser Ala Gly Ser Arg Ile Glu Asp Gly Val Leu Gln Phe 
                325                 330                 335     


Leu Val Leu Leu Val Ala Gly Arg Ser Ser Asp Arg Val Asp Gly Pro 
            340                 345                 350         


Ala Ser Asn Leu Lys Gln Ser Gly Val Val Pro Phe Ile Phe Gln Ala 
        355                 360                 365             


Lys Asn Ala Asp Pro Ala Glu Leu Glu Gln Ile Val Leu Ser Pro Ala 
    370                 375                 380                 


Phe Ile Leu Ala Ala Glu Ser Leu Pro Lys Ile Gly Asp Leu His Pro 
385                 390                 395                 400 


Gln Ile Val Asn Leu Leu Lys Ser Val His Asn Gly Ala Pro Ala Pro 
                405                 410                 415     


Val Ser Gly Glu Lys Asp Val Val Phe Leu Leu Asp Gly Ser Glu Gly 
            420                 425                 430         


Val Arg Ser Gly Phe Pro Leu Leu Lys Glu Phe Val Gln Arg Val Val 
        435                 440                 445             


Glu Ser Leu Asp Val Gly Gln Asp Arg Val Arg Val Ala Val Val Gln 
    450                 455                 460                 


Tyr Ser Asp Arg Thr Arg Pro Glu Phe Tyr Leu Asn Ser Tyr Met Asn 
465                 470                 475                 480 


Lys Gln Asp Val Val Asn Ala Val Arg Gln Leu Thr Leu Leu Gly Gly 
                485                 490                 495     


Pro Thr Pro Asn Thr Gly Ala Ala Leu Glu Phe Val Leu Arg Asn Ile 
            500                 505                 510         


Leu Val Ser Ser Ala Gly Ser Arg Ile Thr Glu Gly Val Pro Gln Leu 
        515                 520                 525             


Leu Ile Val Leu Thr Ala Asp Arg Ser Gly Asp Asp Val Arg Asn Pro 
    530                 535                 540                 


Ser Val Val Val Lys Arg Gly Gly Ala Val Pro Ile Gly Ile Gly Ile 
545                 550                 555                 560 


Gly Asn Ala Asp Ile Thr Glu Met Gln Thr Ile Ser Phe Ile Pro Asp 
                565                 570                 575     


Phe Ala Val Ala Ile Pro Thr Phe Arg Gln Leu Gly Thr Val Gln Gln 
            580                 585                 590         


Val Ile Ser Glu Arg Val Thr Gln Leu Thr Arg Glu Glu Leu Ser Arg 
        595                 600                 605             


Leu Gln Pro Val Leu Gln Pro Leu Pro Ser Pro Gly Val Gly Gly Lys 
    610                 615                 620                 


Arg Asp Val Val Phe Leu Ile Asp Gly Ser Gln Ser Ala Gly Pro Glu 
625                 630                 635                 640 


Phe Gln Tyr Val Arg Thr Leu Ile Glu Arg Leu Val Asp Tyr Leu Asp 
                645                 650                 655     


Val Gly Phe Asp Thr Thr Arg Val Ala Val Ile Gln Phe Ser Asp Asp 
            660                 665                 670         


Pro Lys Val Glu Phe Leu Leu Asn Ala His Ser Ser Lys Asp Glu Val 
        675                 680                 685             


Gln Asn Ala Val Gln Arg Leu Arg Pro Lys Gly Gly Arg Gln Ile Asn 
    690                 695                 700                 


Val Gly Asn Ala Leu Glu Tyr Val Ser Arg Asn Ile Phe Lys Arg Pro 
705                 710                 715                 720 


Leu Gly Ser Arg Ile Glu Glu Gly Val Pro Gln Phe Leu Val Leu Ile 
                725                 730                 735     


Ser Ser Gly Lys Ser Asp Asp Glu Val Asp Asp Pro Ala Val Glu Leu 
            740                 745                 750         


Lys Gln Phe Gly Val Ala Pro Phe Thr Ile Ala Arg Asn Ala Asp Gln 
        755                 760                 765             


Glu Glu Leu Val Lys Ile Ser Leu Ser Pro Glu Tyr Val Phe Ser Val 
    770                 775                 780                 


Ser Thr Phe Arg Glu Leu Pro Ser Leu Glu Gln Lys Leu Leu Thr Pro 
785                 790                 795                 800 


Ile Thr Thr Leu Thr Ser Glu Gln Ile Gln Lys Leu Leu Ala Ser Thr 
                805                 810                 815     


Arg Tyr Pro Pro Pro Ala Val Glu Ser Asp Ala Ala Asp Ile Val Phe 
            820                 825                 830         


Leu Ile Asp Ser Ser Glu Gly Val Arg Pro Asp Gly Phe Ala His Ile 
        835                 840                 845             


Arg Asp Phe Val Ser Arg Ile Val Arg Arg Leu Asn Ile Gly Pro Ser 
    850                 855                 860                 


Lys Val Arg Val Gly Val Val Gln Phe Ser Asn Asp Val Phe Pro Glu 
865                 870                 875                 880 


Phe Tyr Leu Lys Thr Tyr Arg Ser Gln Ala Pro Val Leu Asp Ala Ile 
                885                 890                 895     


Arg Arg Leu Arg Leu Arg Gly Gly Ser Pro Leu Asn Thr Gly Lys Ala 
            900                 905                 910         


Leu Glu Phe Val Ala Arg Asn Leu Phe Val Lys Ser Ala Gly Ser Arg 
        915                 920                 925             


Ile Glu Asp Gly Val Pro Gln His Leu Val Leu Val Leu Gly Gly Lys 
    930                 935                 940                 


Ser Gln Asp Asp Val Ser Arg Phe Ala Gln Val Ile Arg Ser Ser Gly 
945                 950                 955                 960 


Ile Val Ser Leu Gly Val Gly Asp Arg Asn Ile Asp Arg Thr Glu Leu 
                965                 970                 975     


Gln Thr Ile Thr Asn Asp Pro Arg Leu Val Phe Thr Val Arg Glu Phe 
            980                 985                 990         


Arg Glu Leu Pro Asn Ile Glu Glu  Arg Ile Met Asn Ser  Phe Gly Pro 
        995                 1000                 1005             


Ser Ala  Ala Thr Pro Ala Pro  Pro Gly Val Asp Thr  Pro Pro Pro 
    1010                 1015                 1020             


Ser Arg  Pro Glu Lys Lys Lys  Ala Asp Ile Val Phe  Leu Leu Asp 
    1025                 1030                 1035             


Gly Ser  Ile Asn Phe Arg Arg  Asp Ser Phe Gln Glu  Val Leu Arg 
    1040                 1045                 1050             


Phe Val  Ser Glu Ile Val Asp  Thr Val Tyr Glu Asp  Gly Asp Ser 
    1055                 1060                 1065             


Ile Gln  Val Gly Leu Val Gln  Tyr Asn Ser Asp Pro  Thr Asp Glu 
    1070                 1075                 1080             


Phe Phe  Leu Lys Asp Phe Ser  Thr Lys Arg Gln Ile  Ile Asp Ala 
    1085                 1090                 1095             


Ile Asn  Lys Val Val Tyr Lys  Gly Gly Arg His Ala  Asn Thr Lys 
    1100                 1105                 1110             


Val Gly  Leu Glu His Leu Arg  Val Asn His Phe Val  Pro Glu Ala 
    1115                 1120                 1125             


Gly Ser  Arg Leu Asp Gln Arg  Val Pro Gln Ile Ala  Phe Val Ile 
    1130                 1135                 1140             


Thr Gly  Gly Lys Ser Val Glu  Asp Ala Gln Asp Val  Ser Leu Ala 
    1145                 1150                 1155             


Leu Thr  Gln Arg Gly Val Lys  Val Phe Ala Val Gly  Val Arg Asn 
    1160                 1165                 1170             


Ile Asp  Ser Glu Glu Val Gly  Lys Ile Ala Ser Asn  Ser Ala Thr 
    1175                 1180                 1185             


Ala Phe  Arg Val Gly Asn Val  Gln Glu Leu Ser Glu  Leu Ser Glu 
    1190                 1195                 1200             


Gln Val  Leu Glu Thr Leu His  Asp Ala Met His Glu  Thr Leu Cys 
    1205                 1210                 1215             


Pro Gly  Val Thr Asp Ala Ala  Lys Ala Cys Asn Leu  Asp Val Ile 
    1220                 1225                 1230             


Leu Gly  Phe Asp Gly Ser Arg  Asp Gln Asn Val Phe  Val Ala Gln 
    1235                 1240                 1245             


Lys Gly  Phe Glu Ser Lys Val  Asp Ala Ile Leu Asn  Arg Ile Ser 
    1250                 1255                 1260             


Gln Met  His Arg Val Ser Cys  Ser Gly Gly Arg Ser  Pro Thr Val 
    1265                 1270                 1275             


Arg Val  Ser Val Val Ala Asn  Thr Pro Ser Gly Pro  Val Glu Ala 
    1280                 1285                 1290             


Phe Asp  Phe Asp Glu Tyr Gln  Pro Glu Met Leu Glu  Lys Phe Arg 
    1295                 1300                 1305             


Asn Met  Arg Ser Gln His Pro  Tyr Val Leu Thr Glu  Asp Thr Leu 
    1310                 1315                 1320             


Lys Val  Tyr Leu Asn Lys Phe  Arg Gln Ser Ser Pro  Asp Ser Val 
    1325                 1330                 1335             


Lys Val  Val Ile His Phe Thr  Asp Gly Ala Asp Gly  Asp Leu Ala 
    1340                 1345                 1350             


Asp Leu  His Arg Ala Ser Glu  Asn Leu Arg Gln Glu  Gly Val Arg 
    1355                 1360                 1365             


Ala Leu  Ile Leu Val Gly Leu  Glu Arg Val Val Asn  Leu Glu Arg 
    1370                 1375                 1380             


Leu Met  His Leu Glu Phe Gly  Arg Gly Phe Met Tyr  Asp Arg Pro 
    1385                 1390                 1395             


Leu Arg  Leu Asn Leu Leu Asp  Leu Asp Tyr Glu Leu  Ala Glu Gln 
    1400                 1405                 1410             


Leu Asp  Asn Ile Ala Glu Lys  Ala Cys Cys Gly Val  Pro Cys Lys 
    1415                 1420                 1425             


Cys Ser  Gly Gln Arg Gly Asp  Arg Gly Pro Ile Gly  Ser Ile Gly 
    1430                 1435                 1440             


Pro Lys  Gly Ile Pro Gly Glu  Asp Gly Tyr Arg Gly  Tyr Pro Gly 
    1445                 1450                 1455             


Asp Glu  Gly Gly Pro Gly Glu  Arg Gly Pro Pro Gly  Val Asn Gly 
    1460                 1465                 1470             


Thr Gln  Gly Phe Gln Gly Cys  Pro Gly Gln Arg Gly  Val Lys Gly 
    1475                 1480                 1485             


Ser Arg  Gly Phe Pro Gly Glu  Lys Gly Glu Val Gly  Glu Ile Gly 
    1490                 1495                 1500             


Leu Asp  Gly Leu Asp Gly Glu  Asp Gly Asp Lys Gly  Leu Pro Gly 
    1505                 1510                 1515             


Ser Ser  Gly Glu Lys Gly Asn  Pro Gly Arg Arg Gly  Asp Lys Gly 
    1520                 1525                 1530             


Pro Arg  Gly Glu Lys Gly Glu  Arg Gly Asp Val Gly  Ile Arg Gly 
    1535                 1540                 1545             


Asp Pro  Gly Asn Pro Gly Gln  Asp Ser Gln Glu Arg  Gly Pro Lys 
    1550                 1555                 1560             


Gly Glu  Thr Gly Asp Leu Gly  Pro Met Gly Val Pro  Gly Arg Asp 
    1565                 1570                 1575             


Gly Val  Pro Gly Gly Pro Gly  Glu Thr Gly Lys Asn  Gly Gly Phe 
    1580                 1585                 1590             


Gly Arg  Arg Gly Pro Pro Gly  Ala Lys Gly Asn Lys  Gly Gly Pro 
    1595                 1600                 1605             


Gly Gln  Pro Gly Phe Glu Gly  Glu Gln Gly Thr Arg  Gly Ala Gln 
    1610                 1615                 1620             


Gly Pro  Ala Gly Pro Ala Gly  Pro Pro Gly Leu Ile  Gly Glu Gln 
    1625                 1630                 1635             


Gly Ile  Ser Gly Pro Arg Gly  Ser Gly Gly Ala Ala  Gly Ala Pro 
    1640                 1645                 1650             


Gly Glu  Arg Gly Arg Thr Gly  Pro Leu Gly Arg Lys  Gly Glu Pro 
    1655                 1660                 1665             


Gly Glu  Pro Gly Pro Lys Gly  Gly Ile Gly Asn Arg  Gly Pro Arg 
    1670                 1675                 1680             


Gly Glu  Thr Gly Asp Asp Gly  Arg Asp Gly Val Gly  Ser Glu Gly 
    1685                 1690                 1695             


Arg Arg  Gly Lys Lys Gly Glu  Arg Gly Phe Pro Gly  Tyr Pro Gly 
    1700                 1705                 1710             


Pro Lys  Gly Asn Pro Gly Glu  Pro Gly Leu Asn Gly  Thr Thr Gly 
    1715                 1720                 1725             


Pro Lys  Gly Ile Arg Gly Arg  Arg Gly Asn Ser Gly  Pro Pro Gly 
    1730                 1735                 1740             


Ile Val  Gly Gln Lys Gly Asp  Pro Gly Tyr Pro Gly  Pro Ala Gly 
    1745                 1750                 1755             


Pro Lys  Gly Asn Arg Gly Asp  Ser Ile Asp Gln Cys  Ala Leu Ile 
    1760                 1765                 1770             


Gln Ser  Ile Lys Asp Lys Cys  Pro Cys Cys Tyr Gly  Pro Leu Glu 
    1775                 1780                 1785             


Cys Pro  Val Phe Pro Thr Glu  Leu Ala Phe Ala Leu  Asp Thr Ser 
    1790                 1795                 1800             


Glu Gly  Val Asn Gln Asp Thr  Phe Gly Arg Met Arg  Asp Val Val 
    1805                 1810                 1815             


Leu Ser  Ile Val Asn Asp Leu  Thr Ile Ala Glu Ser  Asn Cys Pro 
    1820                 1825                 1830             


Arg Gly  Ala Arg Val Ala Val  Val Thr Tyr Asn Asn  Glu Val Thr 
    1835                 1840                 1845             


Thr Glu  Ile Arg Phe Ala Asp  Ser Lys Arg Lys Ser  Val Leu Leu 
    1850                 1855                 1860             


Asp Lys  Ile Lys Asn Leu Gln  Val Ala Leu Thr Ser  Lys Gln Gln 
    1865                 1870                 1875             


Ser Leu  Glu Thr Ala Met Ser  Phe Val Ala Arg Asn  Thr Phe Lys 
    1880                 1885                 1890             


Arg Val  Arg Asn Gly Phe Leu  Met Arg Lys Val Ala  Val Phe Phe 
    1895                 1900                 1905             


Ser Asn  Thr Pro Thr Arg Ala  Ser Pro Gln Leu Arg  Glu Ala Val 
    1910                 1915                 1920             


Leu Lys  Leu Ser Asp Ala Gly  Ile Thr Pro Leu Phe  Leu Thr Arg 
    1925                 1930                 1935             


Gln Glu  Asp Arg Gln Leu Ile  Asn Ala Leu Gln Ile  Asn Asn Thr 
    1940                 1945                 1950             


Ala Val  Gly His Ala Leu Val  Leu Pro Ala Gly Arg  Asp Leu Thr 
    1955                 1960                 1965             


Asp Phe  Leu Glu Asn Val Leu  Thr Cys His Val Cys  Leu Asp Ile 
    1970                 1975                 1980             


Cys Asn  Ile Asp Pro Ser Cys  Gly Phe Gly Ser Trp  Arg Pro Ser 
    1985                 1990                 1995             


Phe Arg  Asp Arg Arg Ala Ala  Gly Ser Asp Val Asp  Ile Asp Met 
    2000                 2005                 2010             


Ala Phe  Ile Leu Asp Ser Ala  Glu Thr Thr Thr Leu  Phe Gln Phe 
    2015                 2020                 2025             


Asn Glu  Met Lys Lys Tyr Ile  Ala Tyr Leu Val Arg  Gln Leu Asp 
    2030                 2035                 2040             


Met Ser  Pro Asp Pro Lys Ala  Ser Gln His Phe Ala  Arg Val Ala 
    2045                 2050                 2055             


Val Val  Gln His Ala Pro Ser  Glu Ser Val Asp Asn  Ala Ser Met 
    2060                 2065                 2070             


Pro Pro  Val Lys Val Glu Phe  Ser Leu Thr Asp Tyr  Gly Ser Lys 
    2075                 2080                 2085             


Glu Lys  Leu Val Asp Phe Leu  Ser Arg Gly Met Thr  Gln Leu Gln 
    2090                 2095                 2100             


Gly Thr  Arg Ala Leu Gly Ser  Ala Ile Glu Tyr Thr  Ile Glu Asn 
    2105                 2110                 2115             


Val Phe  Glu Ser Ala Pro Asn  Pro Arg Asp Leu Lys  Ile Val Val 
    2120                 2125                 2130             


Leu Met  Leu Thr Gly Glu Val  Pro Glu Gln Gln Leu  Glu Glu Ala 
    2135                 2140                 2145             


Gln Arg  Val Ile Leu Gln Ala  Lys Cys Lys Gly Tyr  Phe Phe Val 
    2150                 2155                 2160             


Val Leu  Gly Ile Gly Arg Lys  Val Asn Ile Lys Glu  Val Tyr Thr 
    2165                 2170                 2175             


Phe Ala  Ser Glu Pro Asn Asp  Val Phe Phe Lys Leu  Val Asp Lys 
    2180                 2185                 2190             


Ser Thr  Glu Leu Asn Glu Glu  Pro Leu Met Arg Phe  Gly Arg Leu 
    2195                 2200                 2205             


Leu Pro  Ser Phe Val Ser Ser  Glu Asn Ala Phe Tyr  Leu Ser Pro 
    2210                 2215                 2220             


Asp Ile  Arg Lys Gln Cys Asp  Trp Phe Gln Gly Asp  Gln Pro Thr 
    2225                 2230                 2235             


Lys Asn  Leu Val Lys Phe Gly  His Lys Gln Val Asn  Val Pro Asn 
    2240                 2245                 2250             


Asn Val  Thr Ser Ser Pro Thr  Ser Asn Pro Val Thr  Thr Thr Lys 
    2255                 2260                 2265             


Pro Val  Thr Thr Thr Lys Pro  Val Thr Thr Thr Thr  Lys Pro Val 
    2270                 2275                 2280             


Thr Thr  Thr Thr Lys Pro Val  Thr Ile Ile Asn Gln  Pro Ser Val 
    2285                 2290                 2295             


Lys Pro  Ala Ala Ala Lys Pro  Ala Pro Ala Lys Pro  Val Ala Ala 
    2300                 2305                 2310             


Lys Pro  Val Ala Thr Lys Met  Ala Thr Val Arg Pro  Pro Val Ala 
    2315                 2320                 2325             


Val Lys  Pro Ala Thr Ala Ala  Lys Pro Val Ala Ala  Lys Pro Ala 
    2330                 2335                 2340             


Ala Val  Arg Pro Pro Ala Ala  Ala Ala Ala Lys Pro  Val Ala Thr 
    2345                 2350                 2355             


Lys Pro  Glu Val Pro Arg Pro  Gln Ala Ala Lys Pro  Ala Ala Thr 
    2360                 2365                 2370             


Lys Pro  Ala Thr Thr Lys Pro  Met Val Lys Met Ser  Arg Glu Val 
    2375                 2380                 2385             


Gln Val  Phe Glu Ile Thr Glu  Asn Ser Ala Lys Leu  His Trp Glu 
    2390                 2395                 2400             


Arg Ala  Glu Pro Pro Gly Pro  Tyr Phe Tyr Asp Leu  Thr Val Thr 
    2405                 2410                 2415             


Ser Ala  His Asp Gln Ser Leu  Val Leu Lys Gln Asn  Leu Thr Val 
    2420                 2425                 2430             


Thr Asp  Arg Val Ile Gly Gly  Leu Leu Ala Gly Gln  Thr Tyr His 
    2435                 2440                 2445             


Val Ala  Val Val Cys Tyr Leu  Arg Ser Gln Val Arg  Ala Thr Tyr 
    2450                 2455                 2460             


His Gly  Ser Phe Ser Thr Lys  Lys Ser Gln Pro Pro  Pro Pro Gln 
    2465                 2470                 2475             


Pro Ala  Arg Ser Ala Ser Ser  Ser Thr Ile Asn Leu  Met Val Ser 
    2480                 2485                 2490             


Thr Glu  Pro Leu Ala Leu Thr  Glu Thr Asp Ile Cys  Lys Leu Pro 
    2495                 2500                 2505             


Lys Asp  Glu Gly Thr Cys Arg  Asp Phe Ile Leu Lys  Trp Tyr Tyr 
    2510                 2515                 2520             


Asp Pro  Asn Thr Lys Ser Cys  Ala Arg Phe Trp Tyr  Gly Gly Cys 
    2525                 2530                 2535             


Gly Gly  Asn Glu Asn Lys Phe  Gly Ser Gln Lys Glu  Cys Glu Lys 
    2540                 2545                 2550             


Val Cys  Ala Pro Val Leu Ala  Lys Pro Gly Val Ile  Ser Val Met 
    2555                 2560                 2565             


Gly Thr  
    2570 


<210>  3336
<211>  1036
<212>  PRT
<213>  Homo Sapiens

<400>  3336

Met Arg Lys His Arg His Leu Pro Leu Val Ala Val Phe Cys Leu Phe 
1               5                   10                  15      


Leu Ser Gly Phe Pro Thr Thr His Ala Gln Gln Gln Gln Ala Val Ile 
            20                  25                  30          


Glu Val Asn Lys Arg Asp Ile Val Phe Leu Val Asp Gly Ser Ser Ala 
        35                  40                  45              


Leu Gly Leu Ala Asn Phe Asn Ala Ile Arg Asp Phe Ile Ala Lys Val 
    50                  55                  60                  


Ile Gln Arg Leu Glu Ile Gly Gln Asp Leu Ile Gln Val Ala Val Ala 
65                  70                  75                  80  


Gln Tyr Ala Asp Thr Val Arg Pro Glu Phe Tyr Phe Asn Thr His Pro 
                85                  90                  95      


Thr Lys Arg Glu Val Ile Thr Ala Val Arg Lys Met Lys Pro Leu Asp 
            100                 105                 110         


Gly Ser Ala Leu Tyr Thr Gly Ser Ala Leu Asp Phe Val Arg Asn Asn 
        115                 120                 125             


Leu Phe Thr Ser Ser Ala Gly Tyr Arg Ala Ala Glu Gly Ile Pro Lys 
    130                 135                 140                 


Leu Leu Val Leu Ile Thr Gly Gly Lys Ser Leu Asp Glu Ile Ser Gln 
145                 150                 155                 160 


Pro Ala Gln Glu Leu Lys Arg Ser Ser Ile Met Ala Phe Ala Ile Gly 
                165                 170                 175     


Asn Lys Gly Ala Asp Gln Ala Glu Leu Glu Glu Ile Ala Phe Asp Ser 
            180                 185                 190         


Ser Leu Val Phe Ile Pro Ala Glu Phe Arg Ala Ala Pro Leu Gln Gly 
        195                 200                 205             


Met Leu Pro Gly Leu Leu Ala Pro Leu Arg Thr Leu Ser Gly Thr Pro 
    210                 215                 220                 


Glu Val His Ser Asn Lys Arg Asp Ile Ile Phe Leu Leu Asp Gly Ser 
225                 230                 235                 240 


Ala Asn Val Gly Lys Thr Asn Phe Pro Tyr Val Arg Asp Phe Val Met 
                245                 250                 255     


Asn Leu Val Asn Ser Leu Asp Ile Gly Asn Asp Asn Ile Arg Val Gly 
            260                 265                 270         


Leu Val Gln Phe Ser Asp Thr Pro Val Thr Glu Phe Ser Leu Asn Thr 
        275                 280                 285             


Tyr Gln Thr Lys Ser Asp Ile Leu Gly His Leu Arg Gln Leu Gln Leu 
    290                 295                 300                 


Gln Gly Gly Ser Gly Leu Asn Thr Gly Ser Ala Leu Ser Tyr Val Tyr 
305                 310                 315                 320 


Ala Asn His Phe Thr Glu Ala Gly Gly Ser Arg Ile Arg Glu His Val 
                325                 330                 335     


Pro Gln Leu Leu Leu Leu Leu Thr Ala Gly Gln Ser Glu Asp Ser Tyr 
            340                 345                 350         


Leu Gln Ala Ala Asn Ala Leu Thr Arg Ala Gly Ile Leu Thr Phe Cys 
        355                 360                 365             


Val Gly Ala Ser Gln Ala Asn Lys Ala Glu Leu Glu Gln Ile Ala Phe 
    370                 375                 380                 


Asn Pro Ser Leu Val Tyr Leu Met Asp Asp Phe Ser Ser Leu Pro Ala 
385                 390                 395                 400 


Leu Pro Gln Gln Leu Ile Gln Pro Leu Thr Thr Tyr Val Ser Gly Gly 
                405                 410                 415     


Val Glu Glu Val Pro Leu Ala Gln Pro Glu Ser Lys Arg Asp Ile Leu 
            420                 425                 430         


Phe Leu Phe Asp Gly Ser Ala Asn Leu Val Gly Gln Phe Pro Val Val 
        435                 440                 445             


Arg Asp Phe Leu Tyr Lys Ile Ile Asp Glu Leu Asn Val Lys Pro Glu 
    450                 455                 460                 


Gly Thr Arg Ile Ala Val Ala Gln Tyr Ser Asp Asp Val Lys Val Glu 
465                 470                 475                 480 


Ser Arg Phe Asp Glu His Gln Ser Lys Pro Glu Ile Leu Asn Leu Val 
                485                 490                 495     


Lys Arg Met Lys Ile Lys Thr Gly Lys Ala Leu Asn Leu Gly Tyr Ala 
            500                 505                 510         


Leu Asp Tyr Ala Gln Arg Tyr Ile Phe Val Lys Ser Ala Gly Ser Arg 
        515                 520                 525             


Ile Glu Asp Gly Val Leu Gln Phe Leu Val Leu Leu Val Ala Gly Arg 
    530                 535                 540                 


Ser Ser Asp Arg Val Asp Gly Pro Ala Ser Asn Leu Lys Gln Ser Gly 
545                 550                 555                 560 


Val Val Pro Phe Ile Phe Gln Ala Lys Asn Ala Asp Pro Ala Glu Leu 
                565                 570                 575     


Glu Gln Ile Val Leu Ser Pro Ala Phe Ile Leu Ala Ala Glu Ser Leu 
            580                 585                 590         


Pro Lys Ile Gly Asp Leu His Pro Gln Ile Val Asn Leu Leu Lys Ser 
        595                 600                 605             


Val His Asn Gly Ala Pro Ala Pro Val Ser Gly Glu Lys Asp Val Val 
    610                 615                 620                 


Phe Leu Leu Asp Gly Ser Glu Gly Val Arg Ser Gly Phe Pro Leu Leu 
625                 630                 635                 640 


Lys Glu Phe Val Gln Arg Val Val Glu Ser Leu Asp Val Gly Gln Asp 
                645                 650                 655     


Arg Val Arg Val Ala Val Val Gln Tyr Ser Asp Arg Thr Arg Pro Glu 
            660                 665                 670         


Phe Tyr Leu Asn Ser Tyr Met Asn Lys Gln Asp Val Val Asn Ala Val 
        675                 680                 685             


Arg Gln Leu Thr Leu Leu Gly Gly Pro Thr Pro Asn Thr Gly Ala Ala 
    690                 695                 700                 


Leu Glu Phe Val Leu Arg Asn Ile Leu Val Ser Ser Ala Gly Ser Arg 
705                 710                 715                 720 


Ile Thr Glu Gly Val Pro Gln Leu Leu Ile Val Leu Thr Ala Asp Arg 
                725                 730                 735     


Ser Gly Asp Asp Val Arg Asn Pro Ser Val Val Val Lys Arg Gly Gly 
            740                 745                 750         


Ala Val Pro Ile Gly Ile Gly Ile Gly Asn Ala Asp Ile Thr Glu Met 
        755                 760                 765             


Gln Thr Ile Ser Phe Ile Pro Asp Phe Ala Val Ala Ile Pro Thr Phe 
    770                 775                 780                 


Arg Gln Leu Gly Thr Val Gln Gln Val Ile Ser Glu Arg Val Thr Gln 
785                 790                 795                 800 


Leu Thr Arg Glu Glu Leu Ser Arg Leu Gln Pro Val Leu Gln Pro Leu 
                805                 810                 815     


Pro Ser Pro Gly Val Gly Gly Lys Arg Asp Val Val Phe Leu Ile Asp 
            820                 825                 830         


Gly Ser Gln Ser Ala Gly Pro Glu Phe Gln Tyr Val Arg Thr Leu Ile 
        835                 840                 845             


Glu Arg Leu Val Asp Tyr Leu Asp Val Gly Phe Asp Thr Thr Arg Val 
    850                 855                 860                 


Ala Val Ile Gln Phe Ser Asp Asp Pro Lys Val Glu Phe Leu Leu Asn 
865                 870                 875                 880 


Ala His Ser Ser Lys Asp Glu Val Gln Asn Ala Val Gln Arg Leu Arg 
                885                 890                 895     


Pro Lys Gly Gly Arg Gln Ile Asn Val Gly Asn Ala Leu Glu Tyr Val 
            900                 905                 910         


Ser Arg Asn Ile Phe Lys Arg Pro Leu Gly Ser Arg Ile Glu Glu Gly 
        915                 920                 925             


Val Pro Gln Phe Leu Val Leu Ile Ser Ser Gly Lys Ser Asp Asp Glu 
    930                 935                 940                 


Val Asp Asp Pro Ala Val Glu Leu Lys Gln Phe Gly Val Ala Pro Phe 
945                 950                 955                 960 


Thr Ile Ala Arg Asn Ala Asp Gln Glu Glu Leu Val Lys Ile Ser Leu 
                965                 970                 975     


Ser Pro Glu Tyr Val Phe Ser Val Ser Thr Phe Arg Glu Leu Pro Ser 
            980                 985                 990         


Leu Glu Gln Lys Leu Leu Thr Pro  Ile Thr Thr Leu Thr  Ser Glu Gln 
        995                 1000                 1005             


Ile Gln  Lys Leu Leu Ala Ser  Thr Arg Tyr Pro Pro  Pro Gly Glu 
    1010                 1015                 1020             


Met Gly  Ala Ser Glu Val Leu  Leu Gly Ala Phe Ser  Ile 
    1025                 1030                 1035     


<210>  3337
<211>  173
<212>  PRT
<213>  Homo Sapiens

<400>  3337

Pro Ile Gly Thr Gln Gln Ile Arg Val Gly Val Val Gln Phe Ser Asp 
1               5                   10                  15      


Glu Pro Arg Thr Met Phe Ser Leu Asp Thr Tyr Ser Thr Lys Ala Gln 
            20                  25                  30          


Val Leu Gly Ala Val Lys Ala Leu Gly Phe Ala Gly Gly Glu Leu Ala 
        35                  40                  45              


Asn Ile Gly Leu Ala Leu Asp Phe Val Val Glu Asn His Phe Thr Arg 
    50                  55                  60                  


Ala Gly Gly Ser Arg Val Glu Glu Gly Val Pro Gln Val Leu Val Leu 
65                  70                  75                  80  


Ile Ser Ala Gly Pro Ser Ser Asp Glu Ile Arg Tyr Gly Val Val Ala 
                85                  90                  95      


Leu Lys Gln Ala Ser Val Phe Ser Phe Gly Leu Gly Ala Gln Ala Ala 
            100                 105                 110         


Ser Arg Ala Glu Leu Gln His Ile Ala Thr Asp Asp Asn Leu Val Phe 
        115                 120                 125             


Thr Val Pro Glu Phe Arg Ser Phe Gly Asp Leu Gln Glu Lys Leu Leu 
    130                 135                 140                 


Pro Tyr Ile Val Gly Val Ala Gln Arg His Ile Val Leu Lys Pro Pro 
145                 150                 155                 160 


Thr Ile Val Thr Gln Glu Tyr Gly Leu Asn Glu Asn Trp 
                165                 170             


<210>  3338
<211>  557
<212>  PRT
<213>  Homo Sapiens

<400>  3338

Ile Gly Arg Ala Leu Leu Trp Thr Thr Glu Asn Leu Phe Pro Glu Thr 
1               5                   10                  15      


Pro Tyr Leu Arg Lys His Lys Val Ile Phe Val Val Ser Ala Gly Glu 
            20                  25                  30          


Asn Tyr Glu Arg Lys Glu Phe Val Lys Met Met Ala Leu Arg Ala Lys 
        35                  40                  45              


Cys Gln Gly Tyr Val Ile Phe Val Ile Ser Leu Gly Ser Thr Arg Lys 
    50                  55                  60                  


Asp Asp Met Glu Glu Leu Ala Ser Tyr Pro Leu Asp Gln His Leu Ile 
65                  70                  75                  80  


Gln Leu Gly Arg Ile His Lys Pro Asp Leu Asn Tyr Ile Ala Lys Phe 
                85                  90                  95      


Leu Lys Pro Phe Leu Tyr Ser Val Arg Arg Gly Phe Asn Gln Tyr Pro 
            100                 105                 110         


Pro Pro Met Leu Glu Asp Ala Cys Arg Leu Ile Asn Leu Gly Gly Glu 
        115                 120                 125             


Asn Ile Gln Asn Asp Gly Phe Gln Phe Val Thr Glu Leu Gln Glu Asp 
    130                 135                 140                 


Phe Leu Gly Gly Asn Gly Phe Ile Gly Gln Glu Leu Asn Ser Gly Arg 
145                 150                 155                 160 


Glu Ser Pro Phe Val Lys Thr Glu Asp Asn Gly Ser Asp Tyr Leu Val 
                165                 170                 175     


Tyr Leu Pro Ser Gln Met Phe Glu Pro Gln Lys Leu Met Ile Asn Tyr 
            180                 185                 190         


Glu Lys Asp Gln Lys Ser Ala Glu Ile Ala Ser Leu Thr Ser Gly His 
        195                 200                 205             


Glu Asn Tyr Gly Arg Lys Glu Glu Pro Asp His Thr Tyr Glu Pro Gly 
    210                 215                 220                 


Asp Val Ser Leu Gln Glu Tyr Tyr Met Asp Val Ala Phe Leu Ile Asp 
225                 230                 235                 240 


Ala Ser Gln Arg Val Gly Ser Asp Glu Phe Lys Glu Val Lys Ala Phe 
                245                 250                 255     


Ile Thr Ser Val Leu Asp Tyr Phe His Ile Ala Pro Thr Pro Leu Thr 
            260                 265                 270         


Ser Thr Leu Gly Asp Arg Val Ala Val Leu Ser Tyr Ser Pro Pro Gly 
        275                 280                 285             


Tyr Met Pro Asn Thr Glu Glu Cys Pro Val Tyr Leu Glu Phe Asp Leu 
    290                 295                 300                 


Val Thr Tyr Asn Ser Ile His Gln Met Lys His His Leu Gln Asp Ser 
305                 310                 315                 320 


Gln Gln Leu Asn Gly Asp Val Phe Ile Gly His Ala Leu Gln Trp Thr 
                325                 330                 335     


Ile Asp Asn Val Phe Val Gly Thr Pro Asn Leu Arg Lys Asn Lys Val 
            340                 345                 350         


Ile Phe Val Ile Ser Ala Gly Glu Thr Asn Ser Leu Asp Lys Asp Val 
        355                 360                 365             


Leu Arg Asn Val Ser Leu Arg Ala Lys Cys Gln Gly Tyr Ser Ile Phe 
    370                 375                 380                 


Val Phe Ser Phe Gly Pro Lys His Asn Asp Lys Glu Leu Glu Glu Leu 
385                 390                 395                 400 


Ala Ser His Pro Leu Asp His His Leu Val Gln Leu Gly Arg Thr His 
                405                 410                 415     


Lys Pro Asp Trp Asn Tyr Ile Ile Lys Phe Val Lys Pro Phe Val His 
            420                 425                 430         


Leu Ile Arg Arg Ala Ile Asn Lys Tyr Pro Thr Glu Asp Met Lys Ala 
        435                 440                 445             


Thr Cys Val Asn Met Thr Ser Pro Asn Pro Glu Asn Gly Gly Thr Glu 
    450                 455                 460                 


Asn Thr Val Leu Leu Leu Pro Gly Ile Tyr Glu Ile Lys Thr Glu Asn 
465                 470                 475                 480 


Gly Asp Leu Phe Asp Glu Phe Asp Ser Gln Ala Gln His Leu Leu Val 
                485                 490                 495     


Leu Gly Asn Asn His Ser Ser Gly Ser Glu Thr Ala Thr Asp Leu Met 
            500                 505                 510         


Gln Lys Leu Tyr Leu Leu Phe Ser Thr Glu Lys Leu Ala Met Lys Asp 
        515                 520                 525             


Lys Glu Lys Ala His Leu Glu Glu Ile Ser Ala Leu Val Val Asp Lys 
    530                 535                 540                 


Gln Gln Glu Lys Glu Asp Gly Glu Asp Thr Arg Ser Ser 
545                 550                 555         


<210>  3339
<211>  2611
<212>  PRT
<213>  Homo Sapiens

<400>  3339

Met Lys Ile Leu Leu Ile Ile Phe Val Leu Ile Ile Trp Thr Glu Thr 
1               5                   10                  15      


Leu Ala Asp Gln Ser Pro Gly Pro Gly Pro Val Tyr Ala Asp Val Val 
            20                  25                  30          


Phe Leu Val Asp Ser Ser Asp His Leu Gly Pro Lys Ser Phe Pro Phe 
        35                  40                  45              


Val Lys Thr Phe Ile Asn Lys Met Ile Asn Ser Leu Pro Ile Glu Ala 
    50                  55                  60                  


Asn Lys Tyr Arg Val Ala Leu Ala Gln Tyr Ser Asp Glu Phe His Ser 
65                  70                  75                  80  


Glu Phe His Leu Ser Thr Phe Lys Gly Arg Ser Pro Met Leu Asn His 
                85                  90                  95      


Leu Lys Lys Asn Phe Gln Phe Ile Gly Gly Ser Leu Gln Ile Gly Lys 
            100                 105                 110         


Ala Leu Gln Glu Ala His Arg Thr Tyr Phe Ser Ala Pro Ile Asn Gly 
        115                 120                 125             


Arg Asp Arg Lys Gln Phe Pro Pro Ile Leu Val Val Leu Ala Ser Ala 
    130                 135                 140                 


Glu Ser Glu Asp Glu Val Glu Glu Ala Ser Lys Ala Leu Gln Lys Asp 
145                 150                 155                 160 


Gly Val Lys Ile Ile Ser Val Gly Val Gln Lys Ala Ser Glu Glu Asn 
                165                 170                 175     


Leu Lys Ala Met Ala Thr Ser His Phe His Phe Asn Leu Arg Thr Ile 
            180                 185                 190         


Arg Asp Leu Ser Thr Phe Ser Gln Asn Met Thr Gln Ile Ile Lys Asp 
        195                 200                 205             


Val Thr Lys Tyr Lys Glu Gly Ala Val Asp Ala Asp Met Gln Val His 
    210                 215                 220                 


Phe Pro Ile Ser Cys Gln Lys Asp Ser Leu Ala Asp Leu Val Phe Leu 
225                 230                 235                 240 


Val Asp Glu Ser Leu Gly Thr Gly Gly Asn Leu Arg His Leu Gln Thr 
                245                 250                 255     


Phe Leu Glu Asn Ile Thr Ser Ser Met Asp Val Lys Glu Asn Cys Met 
            260                 265                 270         


Arg Leu Gly Leu Met Ser Tyr Ser Asn Ser Ala Lys Thr Ile Ser Phe 
        275                 280                 285             


Leu Lys Ser Ser Thr Thr Gln Ser Glu Phe Gln Gln Gln Ile Lys Asn 
    290                 295                 300                 


Leu Ser Ile Gln Val Gly Lys Ser Asn Thr Gly Ala Ala Ile Asp Gln 
305                 310                 315                 320 


Met Arg Arg Asp Gly Phe Ser Glu Ser Tyr Gly Ser Arg Arg Ala Gln 
                325                 330                 335     


Gly Val Pro Gln Ile Ala Val Leu Val Thr His Arg Pro Ser Asp Asp 
            340                 345                 350         


Glu Val His Asp Ala Ala Leu Asn Leu Arg Leu Glu Asp Val Asn Val 
        355                 360                 365             


Phe Ala Leu Ser Ile Gln Gly Ala Asn Asn Thr Gln Leu Glu Glu Ile 
    370                 375                 380                 


Val Ser Tyr Pro Pro Glu Gln Thr Ile Ser Thr Leu Lys Ser Tyr Ala 
385                 390                 395                 400 


Asp Leu Glu Thr Tyr Ser Thr Lys Phe Leu Lys Lys Leu Gln Asn Glu 
                405                 410                 415     


Ile Trp Ser Gln Ile Ser Thr Tyr Ala Glu Gln Arg Asn Leu Asp Lys 
            420                 425                 430         


Thr Gly Cys Val Asp Thr Lys Glu Ala Asp Ile His Phe Leu Ile Asp 
        435                 440                 445             


Gly Ser Ser Ser Ile Gln Glu Lys Gln Phe Glu Gln Ile Lys Arg Phe 
    450                 455                 460                 


Met Leu Glu Val Thr Glu Met Phe Ser Ile Gly Pro Asp Lys Val Arg 
465                 470                 475                 480 


Val Gly Val Val Gln Tyr Ser Asp Asp Thr Glu Val Glu Phe Tyr Ile 
                485                 490                 495     


Thr Asp Tyr Ser Asn Asp Ile Asp Leu Arg Lys Ala Ile Phe Asn Ile 
            500                 505                 510         


Lys Gln Leu Thr Gly Gly Thr Tyr Thr Gly Lys Ala Leu Asp Tyr Ile 
        515                 520                 525             


Leu Gln Ile Ile Lys Asn Gly Met Lys Asp Arg Met Ser Lys Val Pro 
    530                 535                 540                 


Cys Tyr Leu Ile Val Leu Thr Asp Gly Met Ser Thr Asp Arg Val Val 
545                 550                 555                 560 


Glu Pro Ala Lys Arg Leu Arg Ala Glu Gln Ile Thr Val His Ala Val 
                565                 570                 575     


Gly Ile Gly Ala Ala Asn Lys Ile Glu Leu Gln Glu Ile Ala Gly Lys 
            580                 585                 590         


Glu Glu Arg Val Ser Phe Gly Gln Asn Phe Asp Ala Leu Lys Ser Ile 
        595                 600                 605             


Lys Asn Glu Val Val Arg Glu Ile Cys Ala Glu Lys Gly Cys Glu Asp 
    610                 615                 620                 


Met Lys Ala Asp Ile Met Phe Leu Val Asp Ser Ser Trp Ser Ile Gly 
625                 630                 635                 640 


Asn Glu Asn Phe Arg Lys Met Lys Ile Phe Met Lys Asn Leu Leu Thr 
                645                 650                 655     


Lys Ile Gln Ile Gly Ala Asp Lys Thr Gln Ile Gly Val Val Gln Phe 
            660                 665                 670         


Ser Asp Lys Thr Lys Glu Glu Phe Gln Leu Asn Arg Tyr Phe Thr Gln 
        675                 680                 685             


Gln Glu Ile Ser Asp Ala Ile Asp Arg Met Ser Leu Ile Asn Glu Gly 
    690                 695                 700                 


Thr Leu Thr Gly Lys Ala Leu Asn Phe Val Gly Gln Tyr Phe Thr His 
705                 710                 715                 720 


Ser Lys Gly Ala Arg Leu Gly Ala Lys Lys Phe Leu Ile Leu Ile Thr 
                725                 730                 735     


Asp Gly Val Ala Gln Asp Asp Val Arg Asp Pro Ala Arg Ile Leu Arg 
            740                 745                 750         


Gly Lys Asp Val Thr Ile Phe Ser Val Gly Val Tyr Asn Ala Asn Arg 
        755                 760                 765             


Ser Gln Leu Glu Glu Ile Ser Gly Asp Ser Ser Leu Val Phe His Val 
    770                 775                 780                 


Glu Asn Phe Asp His Leu Lys Ala Leu Glu Arg Lys Leu Ile Phe Arg 
785                 790                 795                 800 


Val Cys Ala Leu His Asp Cys Lys Arg Ile Thr Leu Leu Asp Val Val 
                805                 810                 815     


Phe Val Leu Asp His Ser Gly Ser Ile Lys Lys Gln Tyr Gln Asp His 
            820                 825                 830         


Met Ile Asn Leu Thr Ile His Leu Val Lys Lys Ala Asp Val Gly Arg 
        835                 840                 845             


Asp Arg Val Gln Phe Gly Ala Leu Lys Tyr Ser Asp Gln Pro Asn Ile 
    850                 855                 860                 


Leu Phe Tyr Leu Asn Thr Tyr Ser Asn Arg Ser Ala Ile Ile Glu Asn 
865                 870                 875                 880 


Leu Arg Lys Arg Arg Asp Thr Gly Gly Asn Thr Tyr Thr Ala Lys Ala 
                885                 890                 895     


Leu Lys His Ala Asn Ala Leu Phe Thr Glu Glu His Gly Ser Arg Ile 
            900                 905                 910         


Lys Gln Asn Val Lys Gln Met Leu Ile Val Ile Thr Asp Gly Glu Ser 
        915                 920                 925             


His Asp His Asp Gln Leu Asn Asp Thr Ala Leu Glu Leu Arg Asn Lys 
    930                 935                 940                 


Gly Ile Thr Ile Phe Ala Val Gly Val Gly Lys Ala Asn Gln Lys Glu 
945                 950                 955                 960 


Leu Glu Gly Met Ala Gly Asn Lys Asn Asn Thr Ile Tyr Val Asp Asn 
                965                 970                 975     


Phe Asp Lys Leu Lys Asp Val Phe Thr Leu Val Gln Glu Arg Met Cys 
            980                 985                 990         


Thr Glu Ala Pro Glu Val Cys His  Leu Gln Glu Ala Asp  Val Ile Phe 
        995                 1000                 1005             


Leu Cys  Asp Gly Ser Asp Arg  Val Ser Asn Ser Asp  Phe Val Thr 
    1010                 1015                 1020             


Met Thr  Thr Phe Leu Ser Asp  Leu Ile Asp Asn Phe  Asp Ile Gln 
    1025                 1030                 1035             


Ser Gln  Arg Met Lys Ile Gly  Met Ala Gln Phe Gly  Ser Asn Tyr 
    1040                 1045                 1050             


Gln Ser  Ile Ile Glu Leu Lys  Asn Ser Leu Thr Lys  Thr Gln Trp 
    1055                 1060                 1065             


Lys Thr  Gln Ile Gln Asn Val  Ser Lys Ser Gly Gly  Phe Pro Arg 
    1070                 1075                 1080             


Ile Asp  Phe Ala Leu Lys Lys  Val Ser Asn Met Phe  Asn Leu His 
    1085                 1090                 1095             


Ala Gly  Gly Arg Arg Asn Ala  Gly Val Pro Gln Thr  Leu Val Val 
    1100                 1105                 1110             


Ile Thr  Ser Gly Asp Pro Arg  Tyr Asp Val Ala Asp  Ala Val Lys 
    1115                 1120                 1125             


Thr Leu  Lys Asp Leu Gly Ile  Cys Val Leu Val Leu  Gly Ile Gly 
    1130                 1135                 1140             


Asp Val  Tyr Lys Glu His Leu  Leu Pro Ile Thr Gly  Asn Ser Glu 
    1145                 1150                 1155             


Lys Ile  Ile Thr Phe Gln Asp  Phe Asp Lys Leu Lys  Asn Val Asp 
    1160                 1165                 1170             


Val Lys  Lys Arg Ile Ile Arg  Glu Ile Cys Gln Ser  Cys Gly Lys 
    1175                 1180                 1185             


Thr Asn  Cys Phe Met Asp Ile  Val Val Gly Phe Asp  Ile Ser Thr 
    1190                 1195                 1200             


His Val  Gln Gly Gln Pro Leu  Phe Gln Gly His Pro  Gln Leu Glu 
    1205                 1210                 1215             


Ser Tyr  Leu Pro Gly Ile Leu  Glu Asp Ile Ser Ser  Ile Lys Gly 
    1220                 1225                 1230             


Val Ser  Cys Gly Ala Gly Thr  Glu Ala Gln Val Ser  Leu Ala Phe 
    1235                 1240                 1245             


Lys Val  Asn Ser Asp Gln Gly  Phe Pro Ala Lys Phe  Gln Ile Tyr 
    1250                 1255                 1260             


Gln Lys  Ala Val Phe Asp Ser  Leu Leu Gln Val Asn  Val Ser Gly 
    1265                 1270                 1275             


Pro Thr  His Leu Asn Ala Gln  Phe Leu Arg Ser Leu  Trp Asp Thr 
    1280                 1285                 1290             


Phe Lys  Asp Lys Ser Ala Ser  Arg Gly Gln Val Leu  Leu Ile Phe 
    1295                 1300                 1305             


Ser Asp  Gly Leu Gln Ser Glu  Ser Asn Ile Met Leu  Glu Asn Gln 
    1310                 1315                 1320             


Ser Asp  Arg Leu Arg Glu Ala  Gly Leu Asp Ala Leu  Leu Val Val 
    1325                 1330                 1335             


Ser Leu  Asn Thr Thr Ala His  His Glu Phe Ser Ser  Phe Glu Phe 
    1340                 1345                 1350             


Gly Lys  Arg Phe Asp Tyr Arg  Thr His Leu Thr Ile  Gly Met Arg 
    1355                 1360                 1365             


Glu Leu  Gly Lys Lys Leu Ser  Gln Tyr Leu Gly Asn  Ile Ala Glu 
    1370                 1375                 1380             


Arg Thr  Cys Cys Cys Thr Phe  Cys Lys Cys Pro Gly  Ile Pro Gly 
    1385                 1390                 1395             


Pro His  Gly Thr Arg Gly Leu  Gln Ala Met Lys Gly  Ser Gln Gly 
    1400                 1405                 1410             


Leu Lys  Gly Ser Arg Gly His  Arg Gly Glu Asp Gly  Asn Pro Gly 
    1415                 1420                 1425             


Val Arg  Gly Asp Thr Gly Pro  Gln Gly Asp Lys Gly  Ile Ala Gly 
    1430                 1435                 1440             


Cys Pro  Gly Ala Trp Gly Gln  Lys Gly Leu Lys Gly  Phe Ser Gly 
    1445                 1450                 1455             


Pro Lys  Gly Gly His Gly Asp  Asp Gly Ile Asp Gly  Leu Asp Gly 
    1460                 1465                 1470             


Glu Glu  Gly Cys His Gly Phe  Pro Gly Ile Lys Gly  Glu Lys Gly 
    1475                 1480                 1485             


Asp Pro  Gly Ser Gln Gly Ser  Pro Gly Ser Arg Gly  Ala Pro Gly 
    1490                 1495                 1500             


Gln Tyr  Gly Glu Lys Gly Phe  Pro Gly Asp Pro Gly  Asn Pro Gly 
    1505                 1510                 1515             


Gln Asn  Asn Asn Ile Lys Gly  Gln Lys Gly Ser Lys  Gly Glu Gln 
    1520                 1525                 1530             


Gly Arg  Gln Gly Arg Ser Gly  Gln Lys Gly Val Gln  Gly Ser Pro 
    1535                 1540                 1545             


Ser Ser  Arg Gly Ser Arg Gly  Arg Glu Gly Gln Arg  Gly Leu Arg 
    1550                 1555                 1560             


Gly Val  Ser Gly Glu Pro Gly  Asn Pro Gly Pro Thr  Gly Thr Leu 
    1565                 1570                 1575             


Gly Ala  Glu Gly Leu Gln Gly  Pro Gln Gly Ser Gln  Gly Asn Pro 
    1580                 1585                 1590             


Gly Arg  Lys Gly Glu Lys Gly  Ser Gln Gly Gln Lys  Gly Pro Gln 
    1595                 1600                 1605             


Gly Ser  Pro Gly Leu Met Gly  Ala Lys Gly Ser Thr  Gly Arg Pro 
    1610                 1615                 1620             


Gly Leu  Leu Gly Lys Lys Gly  Glu Pro Gly Leu Pro  Gly Asp Leu 
    1625                 1630                 1635             


Gly Pro  Val Gly Gln Thr Gly  Gln Arg Gly Arg Gln  Gly Asp Ser 
    1640                 1645                 1650             


Gly Ile  Pro Gly Tyr Gly Gln  Met Gly Arg Lys Gly  Val Lys Gly 
    1655                 1660                 1665             


Pro Arg  Gly Phe Pro Gly Asp  Ala Gly Gln Lys Gly  Asp Ile Gly 
    1670                 1675                 1680             


Asn Pro  Gly Ile Pro Gly Gly  Pro Gly Pro Lys Gly  Phe Arg Gly 
    1685                 1690                 1695             


Leu Ala  Leu Thr Val Gly Leu  Lys Gly Glu Glu Gly  Ser Arg Gly 
    1700                 1705                 1710             


Leu Pro  Gly Pro Pro Gly Gln  Arg Gly Ile Lys Gly  Met Ala Gly 
    1715                 1720                 1725             


Gln Pro  Val Tyr Ser Gln Cys  Asp Leu Ile Arg Phe  Leu Arg Glu 
    1730                 1735                 1740             


His Ser  Leu Phe Lys Asn Ala  Tyr Pro Thr Glu Leu  Val Phe Ala 
    1745                 1750                 1755             


Leu Asp  Asn Ser Tyr Asp Val  Thr Glu Glu Ser Phe  Asn Lys Thr 
    1760                 1765                 1770             


Arg Asp  Ile Ile Thr Ser Ile  Val Asn Asp Leu Asn  Ile Arg Glu 
    1775                 1780                 1785             


Asn Asn  Cys Pro Val Gly Ala  Arg Val Ala Met Val  Ser Tyr Asn 
    1790                 1795                 1800             


Ser Gly  Thr Ser Tyr Leu Ile  Arg Trp Ser Asp Tyr  Asn Arg Lys 
    1805                 1810                 1815             


Lys Gln  Leu Leu Gln Gln Leu  Ser Gln Ile Lys Tyr  Gln Asp Thr 
    1820                 1825                 1830             


Thr Glu  Pro Arg Asp Val Gly  Asn Ala Met Arg Phe  Val Thr Arg 
    1835                 1840                 1845             


Asn Val  Phe Lys Arg Thr Tyr  Ala Gly Ala Asn Val  Arg Arg Val 
    1850                 1855                 1860             


Ala Val  Phe Phe Ser Asn Gly  Gln Thr Ala Ser Arg  Ser Ser Ile 
    1865                 1870                 1875             


Ile Thr  Ala Thr Met Glu Phe  Ser Ala Leu Asp Ile  Ser Pro Thr 
    1880                 1885                 1890             


Val Phe  Ala Phe Asp Glu Arg  Val Phe Leu Glu Ala  Phe Gly Phe 
    1895                 1900                 1905             


Asp Asn  Thr Gly Thr Phe Gln  Val Ile Pro Val Pro  Pro Asn Gly 
    1910                 1915                 1920             


Glu Asn  Gln Thr Leu Glu Arg  Leu Arg Arg Cys Ala  Leu Cys Tyr 
    1925                 1930                 1935             


Asp Lys  Cys Phe Pro Asn Ala  Cys Ile Arg Glu Ala  Phe Leu Pro 
    1940                 1945                 1950             


Glu Asp  Ser Tyr Met Asp Val  Val Phe Leu Ile Asp  Asn Ser Arg 
    1955                 1960                 1965             


Asn Ile  Ala Lys Asp Glu Phe  Lys Ala Val Lys Ala  Leu Val Ser 
    1970                 1975                 1980             


Ser Val  Ile Asp Asn Phe Asn  Ile Ala Ser Asp Pro  Leu Ile Ser 
    1985                 1990                 1995             


Asp Ser  Gly Asp Arg Ile Ala  Leu Leu Ser Tyr Ser  Pro Trp Glu 
    2000                 2005                 2010             


Ser Ser  Arg Arg Lys Met Gly  Thr Val Lys Thr Glu  Phe Asp Phe 
    2015                 2020                 2025             


Ile Thr  Tyr Asp Asn Gln Leu  Leu Met Lys Asn His  Ile Gln Thr 
    2030                 2035                 2040             


Ser Phe  Gln Gln Leu Asn Gly  Glu Ala Thr Ile Gly  Arg Ala Leu 
    2045                 2050                 2055             


Leu Trp  Thr Thr Glu Asn Leu  Phe Pro Glu Thr Pro  Tyr Leu Arg 
    2060                 2065                 2070             


Lys His  Lys Val Ile Phe Val  Val Ser Ala Gly Glu  Asn Tyr Glu 
    2075                 2080                 2085             


Arg Lys  Glu Phe Val Lys Met  Met Ala Leu Arg Ala  Lys Cys Gln 
    2090                 2095                 2100             


Gly Tyr  Val Ile Phe Val Ile  Ser Leu Gly Ser Thr  Arg Lys Asp 
    2105                 2110                 2115             


Asp Met  Glu Glu Leu Ala Ser  Tyr Pro Leu Asp Gln  His Leu Ile 
    2120                 2125                 2130             


Gln Leu  Gly Arg Ile His Lys  Pro Asp Leu Asn Tyr  Ile Ala Lys 
    2135                 2140                 2145             


Phe Leu  Lys Pro Phe Leu Tyr  Ser Val Arg Arg Gly  Phe Asn Gln 
    2150                 2155                 2160             


Tyr Pro  Pro Pro Met Leu Glu  Asp Ala Cys Arg Leu  Ile Asn Leu 
    2165                 2170                 2175             


Gly Gly  Glu Asn Ile Gln Asn  Asp Gly Phe Gln Phe  Val Thr Glu 
    2180                 2185                 2190             


Leu Gln  Glu Asp Phe Leu Gly  Gly Asn Gly Phe Ile  Gly Gln Glu 
    2195                 2200                 2205             


Leu Asn  Ser Gly Arg Glu Ser  Pro Phe Val Lys Thr  Glu Asp Asn 
    2210                 2215                 2220             


Gly Ser  Asp Tyr Leu Val Tyr  Leu Pro Ser Gln Met  Phe Glu Pro 
    2225                 2230                 2235             


Gln Lys  Leu Met Ile Asn Tyr  Glu Lys Asp Gln Lys  Ser Ala Glu 
    2240                 2245                 2250             


Ile Ala  Ser Leu Thr Ser Gly  His Glu Asn Tyr Gly  Arg Lys Glu 
    2255                 2260                 2265             


Glu Pro  Asp His Thr Tyr Glu  Pro Gly Asp Val Ser  Leu Gln Glu 
    2270                 2275                 2280             


Tyr Tyr  Met Asp Val Ala Phe  Leu Ile Asp Ala Ser  Gln Arg Val 
    2285                 2290                 2295             


Gly Ser  Asp Glu Phe Lys Glu  Val Lys Ala Phe Ile  Thr Ser Val 
    2300                 2305                 2310             


Leu Asp  Tyr Phe His Ile Ala  Pro Thr Pro Leu Thr  Ser Thr Leu 
    2315                 2320                 2325             


Gly Asp  Arg Val Ala Val Leu  Ser Tyr Ser Pro Pro  Gly Tyr Met 
    2330                 2335                 2340             


Pro Asn  Thr Glu Glu Cys Pro  Val Tyr Leu Glu Phe  Asp Leu Val 
    2345                 2350                 2355             


Thr Tyr  Asn Ser Ile His Gln  Met Lys His His Leu  Gln Asp Ser 
    2360                 2365                 2370             


Gln Gln  Leu Asn Gly Asp Val  Phe Ile Gly His Ala  Leu Gln Trp 
    2375                 2380                 2385             


Thr Ile  Asp Asn Val Phe Val  Gly Thr Pro Asn Leu  Arg Lys Asn 
    2390                 2395                 2400             


Lys Val  Ile Phe Val Ile Ser  Ala Gly Glu Thr Asn  Ser Leu Asp 
    2405                 2410                 2415             


Lys Asp  Val Leu Arg Asn Val  Ser Leu Arg Ala Lys  Cys Gln Gly 
    2420                 2425                 2430             


Tyr Ser  Ile Phe Val Phe Ser  Phe Gly Pro Lys His  Asn Asp Lys 
    2435                 2440                 2445             


Glu Leu  Glu Glu Leu Ala Ser  His Pro Leu Asp His  His Leu Val 
    2450                 2455                 2460             


Gln Leu  Gly Arg Thr His Lys  Pro Asp Trp Asn Tyr  Ile Ile Lys 
    2465                 2470                 2475             


Phe Val  Lys Pro Phe Val His  Leu Ile Arg Arg Ala  Ile Asn Lys 
    2480                 2485                 2490             


Tyr Pro  Thr Glu Asp Met Lys  Ala Thr Cys Val Asn  Met Thr Ser 
    2495                 2500                 2505             


Pro Asn  Pro Glu Asn Gly Gly  Thr Glu Asn Thr Val  Leu Leu Leu 
    2510                 2515                 2520             


Pro Gly  Ile Tyr Glu Ile Lys  Thr Glu Asn Gly Asp  Leu Phe Asp 
    2525                 2530                 2535             


Glu Phe  Asp Ser Gln Ala Gln  His Leu Leu Val Leu  Gly Asn Asn 
    2540                 2545                 2550             


His Ser  Ser Gly Ser Glu Thr  Ala Thr Asp Leu Met  Gln Lys Leu 
    2555                 2560                 2565             


Tyr Leu  Leu Phe Ser Thr Glu  Lys Leu Ala Met Lys  Asp Lys Glu 
    2570                 2575                 2580             


Lys Ala  His Leu Glu Glu Ile  Ser Ala Leu Val Val  Asp Lys Gln 
    2585                 2590                 2595             


Gln Glu  Lys Glu Asp Lys Glu  Met Glu Ala Thr Asp  Ile 
    2600                 2605                 2610     


<210>  3340
<211>  2615
<212>  PRT
<213>  Homo Sapiens

<400>  3340

Met Lys Ile Leu Leu Ile Ile Phe Val Leu Ile Ile Trp Thr Glu Thr 
1               5                   10                  15      


Leu Ala Asp Gln Ser Pro Gly Pro Gly Pro Val Tyr Ala Asp Val Val 
            20                  25                  30          


Phe Leu Val Asp Ser Ser Asp His Leu Gly Pro Lys Ser Phe Pro Phe 
        35                  40                  45              


Val Lys Thr Phe Ile Asn Lys Met Ile Asn Ser Leu Pro Ile Glu Ala 
    50                  55                  60                  


Asn Lys Tyr Arg Val Ala Leu Ala Gln Tyr Ser Asp Glu Phe His Ser 
65                  70                  75                  80  


Glu Phe His Leu Ser Thr Phe Lys Gly Arg Ser Pro Met Leu Asn His 
                85                  90                  95      


Leu Lys Lys Asn Phe Gln Phe Ile Gly Gly Ser Leu Gln Ile Gly Lys 
            100                 105                 110         


Ala Leu Gln Glu Ala His Arg Thr Tyr Phe Ser Ala Pro Ile Asn Gly 
        115                 120                 125             


Arg Asp Arg Lys Gln Phe Pro Pro Ile Leu Val Val Leu Ala Ser Ala 
    130                 135                 140                 


Glu Ser Glu Asp Glu Val Glu Glu Ala Ser Lys Ala Leu Gln Lys Asp 
145                 150                 155                 160 


Gly Val Lys Ile Ile Ser Val Gly Val Gln Lys Ala Ser Glu Glu Asn 
                165                 170                 175     


Leu Lys Ala Met Ala Thr Ser His Phe His Phe Asn Leu Arg Thr Ile 
            180                 185                 190         


Arg Asp Leu Ser Thr Phe Ser Gln Asn Met Thr Gln Ile Ile Lys Asp 
        195                 200                 205             


Val Thr Lys Tyr Lys Glu Gly Ala Val Asp Ala Asp Met Gln Val His 
    210                 215                 220                 


Phe Pro Ile Ser Cys Gln Lys Asp Ser Leu Ala Asp Leu Val Phe Leu 
225                 230                 235                 240 


Val Asp Glu Ser Leu Gly Thr Gly Gly Asn Leu Arg His Leu Gln Thr 
                245                 250                 255     


Phe Leu Glu Asn Ile Thr Ser Ser Met Asp Val Lys Glu Asn Cys Met 
            260                 265                 270         


Arg Leu Gly Leu Met Ser Tyr Ser Asn Ser Ala Lys Thr Ile Ser Phe 
        275                 280                 285             


Leu Lys Ser Ser Thr Thr Gln Ser Glu Phe Gln Gln Gln Ile Lys Asn 
    290                 295                 300                 


Leu Ser Ile Gln Val Gly Lys Ser Asn Thr Gly Ala Ala Ile Asp Gln 
305                 310                 315                 320 


Met Arg Arg Asp Gly Phe Ser Glu Ser Tyr Gly Ser Arg Arg Ala Gln 
                325                 330                 335     


Gly Val Pro Gln Ile Ala Val Leu Val Thr His Arg Pro Ser Asp Asp 
            340                 345                 350         


Glu Val His Asp Ala Ala Leu Asn Leu Arg Leu Glu Asp Val Asn Val 
        355                 360                 365             


Phe Ala Leu Ser Ile Gln Gly Ala Asn Asn Thr Gln Leu Glu Glu Ile 
    370                 375                 380                 


Val Ser Tyr Pro Pro Glu Gln Thr Ile Ser Thr Leu Lys Ser Tyr Ala 
385                 390                 395                 400 


Asp Leu Glu Thr Tyr Ser Thr Lys Phe Leu Lys Lys Leu Gln Asn Glu 
                405                 410                 415     


Ile Trp Ser Gln Ile Ser Thr Tyr Ala Glu Gln Arg Asn Leu Asp Lys 
            420                 425                 430         


Thr Gly Cys Val Asp Thr Lys Glu Ala Asp Ile His Phe Leu Ile Asp 
        435                 440                 445             


Gly Ser Ser Ser Ile Gln Glu Lys Gln Phe Glu Gln Ile Lys Arg Phe 
    450                 455                 460                 


Met Leu Glu Val Thr Glu Met Phe Ser Ile Gly Pro Asp Lys Val Arg 
465                 470                 475                 480 


Val Gly Val Val Gln Tyr Ser Asp Asp Thr Glu Val Glu Phe Tyr Ile 
                485                 490                 495     


Thr Asp Tyr Ser Asn Asp Ile Asp Leu Arg Lys Ala Ile Phe Asn Ile 
            500                 505                 510         


Lys Gln Leu Thr Gly Gly Thr Tyr Thr Gly Lys Ala Leu Asp Tyr Ile 
        515                 520                 525             


Leu Gln Ile Ile Lys Asn Gly Met Lys Asp Arg Met Ser Lys Val Pro 
    530                 535                 540                 


Cys Tyr Leu Ile Val Leu Thr Asp Gly Met Ser Thr Asp Arg Val Val 
545                 550                 555                 560 


Glu Pro Ala Lys Arg Leu Arg Ala Glu Gln Ile Thr Val His Ala Val 
                565                 570                 575     


Gly Ile Gly Ala Ala Asn Lys Ile Glu Leu Gln Glu Ile Ala Gly Lys 
            580                 585                 590         


Glu Glu Arg Val Ser Phe Gly Gln Asn Phe Asp Ala Leu Lys Ser Ile 
        595                 600                 605             


Lys Asn Glu Val Val Arg Glu Ile Cys Ala Glu Lys Gly Cys Glu Asp 
    610                 615                 620                 


Met Lys Ala Asp Ile Met Phe Leu Val Asp Ser Ser Trp Ser Ile Gly 
625                 630                 635                 640 


Asn Glu Asn Phe Arg Lys Met Lys Ile Phe Met Lys Asn Leu Leu Thr 
                645                 650                 655     


Lys Ile Gln Ile Gly Ala Asp Lys Thr Gln Ile Gly Val Val Gln Phe 
            660                 665                 670         


Ser Asp Lys Thr Lys Glu Glu Phe Gln Leu Asn Arg Tyr Phe Thr Gln 
        675                 680                 685             


Gln Glu Ile Ser Asp Ala Ile Asp Arg Met Ser Leu Ile Asn Glu Gly 
    690                 695                 700                 


Thr Leu Thr Gly Lys Ala Leu Asn Phe Val Gly Gln Tyr Phe Thr His 
705                 710                 715                 720 


Ser Lys Gly Ala Arg Leu Gly Ala Lys Lys Phe Leu Ile Leu Ile Thr 
                725                 730                 735     


Asp Gly Val Ala Gln Asp Asp Val Arg Asp Pro Ala Arg Ile Leu Arg 
            740                 745                 750         


Gly Lys Asp Val Thr Ile Phe Ser Val Gly Val Tyr Asn Ala Asn Arg 
        755                 760                 765             


Ser Gln Leu Glu Glu Ile Ser Gly Asp Ser Ser Leu Val Phe His Val 
    770                 775                 780                 


Glu Asn Phe Asp His Leu Lys Ala Leu Glu Arg Lys Leu Ile Phe Arg 
785                 790                 795                 800 


Val Cys Ala Leu His Asp Cys Lys Arg Ile Thr Leu Leu Asp Val Val 
                805                 810                 815     


Phe Val Leu Asp His Ser Gly Ser Ile Lys Lys Gln Tyr Gln Asp His 
            820                 825                 830         


Met Ile Asn Leu Thr Ile His Leu Val Lys Lys Ala Asp Val Gly Arg 
        835                 840                 845             


Asp Arg Val Gln Phe Gly Ala Leu Lys Tyr Ser Asp Gln Pro Asn Ile 
    850                 855                 860                 


Leu Phe Tyr Leu Asn Thr Tyr Ser Asn Arg Ser Ala Ile Ile Glu Asn 
865                 870                 875                 880 


Leu Arg Lys Arg Arg Asp Thr Gly Gly Asn Thr Tyr Thr Ala Lys Ala 
                885                 890                 895     


Leu Lys His Ala Asn Ala Leu Phe Thr Glu Glu His Gly Ser Arg Ile 
            900                 905                 910         


Lys Gln Asn Val Lys Gln Met Leu Ile Val Ile Thr Asp Gly Glu Ser 
        915                 920                 925             


His Asp His Asp Gln Leu Asn Asp Thr Ala Leu Glu Leu Arg Asn Lys 
    930                 935                 940                 


Gly Ile Thr Ile Phe Ala Val Gly Val Gly Lys Ala Asn Gln Lys Glu 
945                 950                 955                 960 


Leu Glu Gly Met Ala Gly Asn Lys Asn Asn Thr Ile Tyr Val Asp Asn 
                965                 970                 975     


Phe Asp Lys Leu Lys Asp Val Phe Thr Leu Val Gln Glu Arg Met Cys 
            980                 985                 990         


Thr Glu Ala Pro Glu Val Cys His  Leu Gln Glu Ala Asp  Val Ile Phe 
        995                 1000                 1005             


Leu Cys  Asp Gly Ser Asp Arg  Val Ser Asn Ser Asp  Phe Val Thr 
    1010                 1015                 1020             


Met Thr  Thr Phe Leu Ser Asp  Leu Ile Asp Asn Phe  Asp Ile Gln 
    1025                 1030                 1035             


Ser Gln  Arg Met Lys Ile Gly  Met Ala Gln Phe Gly  Ser Asn Tyr 
    1040                 1045                 1050             


Gln Ser  Ile Ile Glu Leu Lys  Asn Ser Leu Thr Lys  Thr Gln Trp 
    1055                 1060                 1065             


Lys Thr  Gln Ile Gln Asn Val  Ser Lys Ser Gly Gly  Phe Pro Arg 
    1070                 1075                 1080             


Ile Asp  Phe Ala Leu Lys Lys  Val Ser Asn Met Phe  Asn Leu His 
    1085                 1090                 1095             


Ala Gly  Gly Arg Arg Asn Ala  Gly Val Pro Gln Thr  Leu Val Val 
    1100                 1105                 1110             


Ile Thr  Ser Gly Asp Pro Arg  Tyr Asp Val Ala Asp  Ala Val Lys 
    1115                 1120                 1125             


Thr Leu  Lys Asp Leu Gly Ile  Cys Val Leu Val Leu  Gly Ile Gly 
    1130                 1135                 1140             


Asp Val  Tyr Lys Glu His Leu  Leu Pro Ile Thr Gly  Asn Ser Glu 
    1145                 1150                 1155             


Lys Ile  Ile Thr Phe Gln Asp  Phe Asp Lys Leu Lys  Asn Val Asp 
    1160                 1165                 1170             


Val Lys  Lys Arg Ile Ile Arg  Glu Ile Cys Gln Ser  Cys Gly Lys 
    1175                 1180                 1185             


Thr Asn  Cys Phe Met Asp Ile  Val Val Gly Phe Asp  Ile Ser Thr 
    1190                 1195                 1200             


His Val  Gln Gly Gln Pro Leu  Phe Gln Gly His Pro  Gln Leu Glu 
    1205                 1210                 1215             


Ser Tyr  Leu Pro Gly Ile Leu  Glu Asp Ile Ser Ser  Ile Lys Gly 
    1220                 1225                 1230             


Val Ser  Cys Gly Ala Gly Thr  Glu Ala Gln Val Ser  Leu Ala Phe 
    1235                 1240                 1245             


Lys Val  Asn Ser Asp Gln Gly  Phe Pro Ala Lys Phe  Gln Ile Tyr 
    1250                 1255                 1260             


Gln Lys  Ala Val Phe Asp Ser  Leu Leu Gln Val Asn  Val Ser Gly 
    1265                 1270                 1275             


Pro Thr  His Leu Asn Ala Gln  Phe Leu Arg Ser Leu  Trp Asp Thr 
    1280                 1285                 1290             


Phe Lys  Asp Lys Ser Ala Ser  Arg Gly Gln Val Leu  Leu Ile Phe 
    1295                 1300                 1305             


Ser Asp  Gly Leu Gln Ser Glu  Ser Asn Ile Met Leu  Glu Asn Gln 
    1310                 1315                 1320             


Ser Asp  Arg Leu Arg Glu Ala  Gly Leu Asp Ala Leu  Leu Val Val 
    1325                 1330                 1335             


Ser Leu  Asn Thr Thr Ala His  His Glu Phe Ser Ser  Phe Glu Phe 
    1340                 1345                 1350             


Gly Lys  Arg Phe Asp Tyr Arg  Thr His Leu Thr Ile  Gly Met Arg 
    1355                 1360                 1365             


Glu Leu  Gly Lys Lys Leu Ser  Gln Tyr Leu Gly Asn  Ile Ala Glu 
    1370                 1375                 1380             


Arg Thr  Cys Cys Cys Thr Phe  Cys Lys Cys Pro Gly  Ile Pro Gly 
    1385                 1390                 1395             


Pro His  Gly Thr Arg Gly Leu  Gln Ala Met Lys Gly  Ser Gln Gly 
    1400                 1405                 1410             


Leu Lys  Gly Ser Arg Gly His  Arg Gly Glu Asp Gly  Asn Pro Gly 
    1415                 1420                 1425             


Val Arg  Gly Asp Thr Gly Pro  Gln Gly Asp Lys Gly  Ile Ala Gly 
    1430                 1435                 1440             


Cys Pro  Gly Ala Trp Gly Gln  Lys Gly Leu Lys Gly  Phe Ser Gly 
    1445                 1450                 1455             


Pro Lys  Gly Gly His Gly Asp  Asp Gly Ile Asp Gly  Leu Asp Gly 
    1460                 1465                 1470             


Glu Glu  Gly Cys His Gly Phe  Pro Gly Ile Lys Gly  Glu Lys Gly 
    1475                 1480                 1485             


Asp Pro  Gly Ser Gln Gly Ser  Pro Gly Ser Arg Gly  Ala Pro Gly 
    1490                 1495                 1500             


Gln Tyr  Gly Glu Lys Gly Phe  Pro Gly Asp Pro Gly  Asn Pro Gly 
    1505                 1510                 1515             


Gln Asn  Asn Asn Ile Lys Gly  Gln Lys Gly Ser Lys  Gly Glu Gln 
    1520                 1525                 1530             


Gly Arg  Gln Gly Arg Ser Gly  Gln Lys Gly Val Gln  Gly Ser Pro 
    1535                 1540                 1545             


Ser Ser  Arg Gly Ser Arg Gly  Arg Glu Gly Gln Arg  Gly Leu Arg 
    1550                 1555                 1560             


Gly Val  Ser Gly Glu Pro Gly  Asn Pro Gly Pro Thr  Gly Thr Leu 
    1565                 1570                 1575             


Gly Ala  Glu Gly Leu Gln Gly  Pro Gln Gly Ser Gln  Gly Asn Pro 
    1580                 1585                 1590             


Gly Arg  Lys Gly Glu Lys Gly  Ser Gln Gly Gln Lys  Gly Pro Gln 
    1595                 1600                 1605             


Gly Ser  Pro Gly Leu Met Gly  Ala Lys Gly Ser Thr  Gly Arg Pro 
    1610                 1615                 1620             


Gly Leu  Leu Gly Lys Lys Gly  Glu Pro Gly Leu Pro  Gly Asp Leu 
    1625                 1630                 1635             


Gly Pro  Val Gly Gln Thr Gly  Gln Arg Gly Arg Gln  Gly Asp Ser 
    1640                 1645                 1650             


Gly Ile  Pro Gly Tyr Gly Gln  Met Gly Arg Lys Gly  Val Lys Gly 
    1655                 1660                 1665             


Pro Arg  Gly Phe Pro Gly Asp  Ala Gly Gln Lys Gly  Asp Ile Gly 
    1670                 1675                 1680             


Asn Pro  Gly Ile Pro Gly Gly  Pro Gly Pro Lys Gly  Phe Arg Gly 
    1685                 1690                 1695             


Leu Ala  Leu Thr Val Gly Leu  Lys Gly Glu Glu Gly  Ser Arg Gly 
    1700                 1705                 1710             


Leu Pro  Gly Pro Pro Gly Gln  Arg Gly Ile Lys Gly  Met Ala Gly 
    1715                 1720                 1725             


Gln Pro  Val Tyr Ser Gln Cys  Asp Leu Ile Arg Phe  Leu Arg Glu 
    1730                 1735                 1740             


His Ser  Pro Cys Trp Lys Glu  Lys Cys Pro Ala Tyr  Pro Thr Glu 
    1745                 1750                 1755             


Leu Val  Phe Ala Leu Asp Asn  Ser Tyr Asp Val Thr  Glu Glu Ser 
    1760                 1765                 1770             


Phe Asn  Lys Thr Arg Asp Ile  Ile Thr Ser Ile Val  Asn Asp Leu 
    1775                 1780                 1785             


Asn Ile  Arg Glu Asn Asn Cys  Pro Val Gly Ala Arg  Val Ala Met 
    1790                 1795                 1800             


Val Ser  Tyr Asn Ser Gly Thr  Ser Tyr Leu Ile Arg  Trp Ser Asp 
    1805                 1810                 1815             


Tyr Asn  Arg Lys Lys Gln Leu  Leu Gln Gln Leu Ser  Gln Ile Lys 
    1820                 1825                 1830             


Tyr Gln  Asp Thr Thr Glu Pro  Arg Asp Val Gly Asn  Ala Met Arg 
    1835                 1840                 1845             


Phe Val  Thr Arg Asn Val Phe  Lys Arg Thr Tyr Ala  Gly Ala Asn 
    1850                 1855                 1860             


Val Arg  Arg Val Ala Val Phe  Phe Ser Asn Gly Gln  Thr Ala Ser 
    1865                 1870                 1875             


Arg Ser  Ser Ile Ile Thr Ala  Thr Met Glu Phe Ser  Ala Leu Asp 
    1880                 1885                 1890             


Ile Ser  Pro Thr Val Phe Ala  Phe Asp Glu Arg Val  Phe Leu Glu 
    1895                 1900                 1905             


Ala Phe  Gly Phe Asp Asn Thr  Gly Thr Phe Gln Val  Ile Pro Val 
    1910                 1915                 1920             


Pro Pro  Asn Gly Glu Asn Gln  Thr Leu Glu Arg Leu  Arg Arg Cys 
    1925                 1930                 1935             


Ala Leu  Cys Tyr Asp Lys Cys  Phe Pro Asn Ala Cys  Ile Arg Glu 
    1940                 1945                 1950             


Ala Phe  Leu Pro Glu Asp Ser  Tyr Met Asp Val Val  Phe Leu Ile 
    1955                 1960                 1965             


Asp Asn  Ser Arg Asn Ile Ala  Lys Asp Glu Phe Lys  Ala Val Lys 
    1970                 1975                 1980             


Ala Leu  Val Ser Ser Val Ile  Asp Asn Phe Asn Ile  Ala Ser Asp 
    1985                 1990                 1995             


Pro Leu  Ile Ser Asp Ser Gly  Asp Arg Ile Ala Leu  Leu Ser Tyr 
    2000                 2005                 2010             


Ser Pro  Trp Glu Ser Ser Arg  Arg Lys Met Gly Thr  Val Lys Thr 
    2015                 2020                 2025             


Glu Phe  Asp Phe Ile Thr Tyr  Asp Asn Gln Leu Leu  Met Lys Asn 
    2030                 2035                 2040             


His Ile  Gln Thr Ser Phe Gln  Gln Leu Asn Gly Glu  Ala Thr Ile 
    2045                 2050                 2055             


Gly Arg  Ala Leu Leu Trp Thr  Thr Glu Asn Leu Phe  Pro Glu Thr 
    2060                 2065                 2070             


Pro Tyr  Leu Arg Lys His Lys  Val Ile Phe Val Val  Ser Ala Gly 
    2075                 2080                 2085             


Glu Asn  Tyr Glu Arg Lys Glu  Phe Val Lys Met Met  Ala Leu Arg 
    2090                 2095                 2100             


Ala Lys  Cys Gln Gly Tyr Val  Ile Phe Val Ile Ser  Leu Gly Ser 
    2105                 2110                 2115             


Thr Arg  Lys Asp Asp Met Glu  Glu Leu Ala Ser Tyr  Pro Leu Asp 
    2120                 2125                 2130             


Gln His  Leu Ile Gln Leu Gly  Arg Ile His Lys Pro  Asp Leu Asn 
    2135                 2140                 2145             


Tyr Ile  Ala Lys Phe Leu Lys  Pro Phe Leu Tyr Ser  Val Arg Arg 
    2150                 2155                 2160             


Gly Phe  Asn Gln Tyr Pro Pro  Pro Met Leu Glu Asp  Ala Cys Arg 
    2165                 2170                 2175             


Leu Ile  Asn Leu Gly Gly Glu  Asn Ile Gln Asn Asp  Gly Phe Gln 
    2180                 2185                 2190             


Phe Val  Thr Glu Leu Gln Glu  Asp Phe Leu Gly Gly  Asn Gly Phe 
    2195                 2200                 2205             


Ile Gly  Gln Glu Leu Asn Ser  Gly Arg Glu Ser Pro  Phe Val Lys 
    2210                 2215                 2220             


Thr Glu  Asp Asn Gly Ser Asp  Tyr Leu Val Tyr Leu  Pro Ser Gln 
    2225                 2230                 2235             


Met Phe  Glu Pro Gln Lys Leu  Met Ile Asn Tyr Glu  Lys Asp Gln 
    2240                 2245                 2250             


Lys Ser  Ala Glu Ile Ala Ser  Leu Thr Ser Gly His  Glu Asn Tyr 
    2255                 2260                 2265             


Gly Arg  Lys Glu Glu Pro Asp  His Thr Tyr Glu Pro  Gly Asp Val 
    2270                 2275                 2280             


Ser Leu  Gln Glu Tyr Tyr Met  Asp Val Ala Phe Leu  Ile Asp Ala 
    2285                 2290                 2295             


Ser Gln  Arg Val Gly Ser Asp  Glu Phe Lys Glu Val  Lys Ala Phe 
    2300                 2305                 2310             


Ile Thr  Ser Val Leu Asp Tyr  Phe His Ile Ala Pro  Thr Pro Leu 
    2315                 2320                 2325             


Thr Ser  Thr Leu Gly Asp Arg  Val Ala Val Leu Ser  Tyr Ser Pro 
    2330                 2335                 2340             


Pro Gly  Tyr Met Pro Asn Thr  Glu Glu Cys Pro Val  Tyr Leu Glu 
    2345                 2350                 2355             


Phe Asp  Leu Val Thr Tyr Asn  Ser Ile His Gln Met  Lys His His 
    2360                 2365                 2370             


Leu Gln  Asp Ser Gln Gln Leu  Asn Gly Asp Val Phe  Ile Gly His 
    2375                 2380                 2385             


Ala Leu  Gln Trp Thr Ile Asp  Asn Val Phe Val Gly  Thr Pro Asn 
    2390                 2395                 2400             


Leu Arg  Lys Asn Lys Val Ile  Phe Val Ile Ser Ala  Gly Glu Thr 
    2405                 2410                 2415             


Asn Ser  Leu Asp Lys Asp Val  Leu Arg Asn Val Ser  Leu Arg Ala 
    2420                 2425                 2430             


Lys Cys  Gln Gly Tyr Ser Ile  Phe Val Phe Ser Phe  Gly Pro Lys 
    2435                 2440                 2445             


His Asn  Asp Lys Glu Leu Glu  Glu Leu Ala Ser His  Pro Leu Asp 
    2450                 2455                 2460             


His His  Leu Val Gln Leu Gly  Arg Thr His Lys Pro  Asp Trp Asn 
    2465                 2470                 2475             


Tyr Ile  Ile Lys Phe Val Lys  Pro Phe Val His Leu  Ile Arg Arg 
    2480                 2485                 2490             


Ala Ile  Asn Lys Tyr Pro Thr  Glu Asp Met Lys Ala  Thr Cys Val 
    2495                 2500                 2505             


Asn Met  Thr Ser Pro Asn Pro  Glu Asn Gly Gly Thr  Glu Asn Thr 
    2510                 2515                 2520             


Val Leu  Leu Leu Pro Gly Ile  Tyr Glu Ile Lys Thr  Glu Asn Gly 
    2525                 2530                 2535             


Asp Leu  Phe Asp Glu Phe Asp  Ser Gln Ala Gln His  Leu Leu Val 
    2540                 2545                 2550             


Leu Gly  Asn Asn His Ser Ser  Gly Ser Glu Thr Ala  Thr Asp Leu 
    2555                 2560                 2565             


Met Gln  Lys Leu Tyr Leu Leu  Phe Ser Thr Glu Lys  Leu Ala Met 
    2570                 2575                 2580             


Lys Asp  Lys Glu Lys Ala His  Leu Glu Glu Ile Ser  Ala Leu Val 
    2585                 2590                 2595             


Val Asp  Lys Gln Gln Glu Lys  Glu Asp Lys Glu Met  Glu Ala Thr 
    2600                 2605                 2610             


Asp Ile  
    2615 


<210>  3341
<211>  443
<212>  PRT
<213>  Homo Sapiens

<400>  3341

Asn Gln Tyr Pro Pro Pro Met Leu Glu Asp Ala Cys Arg Leu Ile Asn 
1               5                   10                  15      


Leu Gly Gly Glu Asn Ile Gln Asn Asp Gly Phe Gln Phe Val Thr Glu 
            20                  25                  30          


Leu Gln Glu Asp Phe Leu Gly Gly Asn Gly Phe Ile Gly Gln Glu Leu 
        35                  40                  45              


Asn Ser Gly Arg Glu Ser Pro Phe Val Lys Thr Glu Asp Asn Gly Ser 
    50                  55                  60                  


Asp Tyr Leu Val Tyr Leu Pro Ser Gln Met Phe Glu Pro Gln Lys Leu 
65                  70                  75                  80  


Met Ile Asn Tyr Glu Lys Asp Gln Lys Ser Ala Glu Ile Ala Ser Leu 
                85                  90                  95      


Thr Ser Gly His Glu Asn Tyr Gly Arg Lys Glu Glu Pro Asp His Thr 
            100                 105                 110         


Tyr Glu Pro Gly Asp Val Ser Leu Gln Glu Tyr Tyr Met Asp Val Ala 
        115                 120                 125             


Phe Leu Ile Asp Ala Ser Gln Arg Val Gly Ser Asp Glu Phe Lys Glu 
    130                 135                 140                 


Val Lys Ala Phe Ile Thr Ser Val Leu Asp Tyr Phe His Ile Ala Pro 
145                 150                 155                 160 


Thr Pro Leu Thr Ser Thr Leu Gly Asp Arg Val Ala Val Leu Ser Tyr 
                165                 170                 175     


Ser Pro Pro Gly Tyr Met Pro Asn Thr Glu Glu Cys Pro Val Tyr Leu 
            180                 185                 190         


Glu Phe Asp Leu Val Thr Tyr Asn Ser Ile His Gln Met Lys His His 
        195                 200                 205             


Leu Gln Asp Ser Gln Gln Leu Asn Gly Asp Val Phe Ile Gly His Ala 
    210                 215                 220                 


Leu Gln Trp Thr Ile Asp Asn Val Phe Val Gly Thr Pro Asn Leu Arg 
225                 230                 235                 240 


Lys Asn Lys Val Ile Phe Val Ile Ser Ala Gly Glu Thr Asn Ser Leu 
                245                 250                 255     


Asp Lys Asp Val Leu Arg Asn Val Ser Leu Arg Ala Lys Cys Gln Gly 
            260                 265                 270         


Tyr Ser Ile Phe Val Phe Ser Phe Gly Pro Lys His Asn Asp Lys Glu 
        275                 280                 285             


Leu Glu Glu Leu Ala Ser His Pro Leu Asp His His Leu Val Gln Leu 
    290                 295                 300                 


Gly Arg Thr His Lys Pro Asp Trp Asn Tyr Ile Ile Lys Phe Val Lys 
305                 310                 315                 320 


Pro Phe Val His Leu Ile Arg Arg Ala Ile Asn Lys Tyr Pro Thr Glu 
                325                 330                 335     


Asp Met Lys Ala Thr Cys Val Asn Met Thr Ser Pro Asn Pro Glu Asn 
            340                 345                 350         


Gly Gly Thr Glu Asn Thr Val Leu Leu Leu Pro Gly Ile Tyr Glu Ile 
        355                 360                 365             


Lys Thr Glu Asn Gly Asp Leu Phe Asp Glu Phe Asp Ser Gln Ala Gln 
    370                 375                 380                 


His Leu Leu Val Leu Gly Asn Asn His Ser Ser Gly Ser Glu Thr Ala 
385                 390                 395                 400 


Thr Asp Leu Met Gln Lys Leu Tyr Leu Leu Phe Ser Thr Glu Lys Leu 
                405                 410                 415     


Ala Met Lys Asp Lys Glu Lys Ala His Leu Glu Glu Ile Ser Ala Leu 
            420                 425                 430         


Val Val Asp Lys Gln Gln Glu Lys Glu Asp Leu 
        435                 440             


<210>  3342
<211>  778
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3342

Xaa Glu Lys Cys Pro Ala Tyr Pro Thr Glu Leu Val Phe Ala Leu Asp 
1               5                   10                  15      


Asn Ser Tyr Asp Val Thr Glu Glu Ser Phe Asn Lys Thr Arg Asp Ile 
            20                  25                  30          


Ile Thr Ser Ile Val Asn Asp Leu Asn Ile Arg Glu Asn Asn Cys Pro 
        35                  40                  45              


Val Gly Ala Arg Val Ala Met Val Ser Tyr Asn Ser Gly Thr Ser Tyr 
    50                  55                  60                  


Leu Ile Arg Trp Ser Asp Tyr Asn Arg Lys Lys Gln Leu Leu Gln Gln 
65                  70                  75                  80  


Leu Ser Gln Ile Lys Tyr Gln Asp Thr Thr Glu Pro Arg Asp Val Gly 
                85                  90                  95      


Asn Ala Met Arg Phe Val Thr Arg Asn Val Phe Lys Arg Thr Tyr Ala 
            100                 105                 110         


Gly Ala Asn Val Arg Arg Val Ala Val Phe Phe Ser Asn Gly Gln Thr 
        115                 120                 125             


Ala Ser Arg Ser Ser Ile Ile Thr Ala Thr Met Glu Phe Ser Ala Leu 
    130                 135                 140                 


Asp Ile Ser Pro Thr Val Phe Ala Phe Asp Glu Arg Val Phe Leu Glu 
145                 150                 155                 160 


Ala Phe Gly Phe Asp Asn Thr Gly Thr Phe Gln Val Ile Pro Val Pro 
                165                 170                 175     


Pro Asn Gly Glu Asn Gln Thr Leu Glu Arg Leu Arg Arg Cys Ala Leu 
            180                 185                 190         


Cys Tyr Asp Lys Cys Phe Pro Asn Ala Cys Ile Arg Glu Ala Phe Leu 
        195                 200                 205             


Pro Glu Asp Ser Tyr Met Asp Val Val Phe Leu Ile Asp Asn Ser Arg 
    210                 215                 220                 


Asn Ile Ala Lys Asp Glu Phe Lys Ala Val Lys Ala Leu Val Ser Ser 
225                 230                 235                 240 


Val Ile Asp Asn Phe Asn Ile Ala Ser Asp Pro Leu Ile Ser Asp Ser 
                245                 250                 255     


Gly Asp Arg Ile Ala Leu Leu Ser Tyr Ser Pro Trp Glu Ser Ser Arg 
            260                 265                 270         


Arg Lys Met Gly Thr Val Lys Thr Glu Phe Asp Phe Ile Thr Tyr Asp 
        275                 280                 285             


Asn Gln Leu Leu Met Lys Asn His Ile Gln Thr Ser Phe Gln Gln Leu 
    290                 295                 300                 


Asn Gly Glu Ala Thr Ile Gly Arg Ala Leu Leu Trp Thr Thr Glu Asn 
305                 310                 315                 320 


Leu Phe Pro Glu Thr Pro Tyr Leu Arg Lys His Lys Val Ile Phe Val 
                325                 330                 335     


Val Ser Ala Gly Glu Asn Tyr Glu Arg Lys Glu Phe Val Lys Met Met 
            340                 345                 350         


Ala Leu Arg Ala Lys Cys Gln Gly Tyr Val Ile Phe Val Ile Ser Leu 
        355                 360                 365             


Gly Ser Thr Arg Lys Asp Asp Met Glu Glu Leu Ala Ser Tyr Pro Leu 
    370                 375                 380                 


Asp Gln His Leu Ile Gln Leu Gly Arg Ile His Lys Pro Asp Leu Asn 
385                 390                 395                 400 


Tyr Ile Ala Lys Phe Leu Lys Pro Phe Leu Tyr Ser Val Arg Arg Gly 
                405                 410                 415     


Phe Asn Gln Tyr Pro Pro Pro Met Leu Glu Asp Ala Cys Arg Leu Ile 
            420                 425                 430         


Asn Leu Gly Gly Glu Asn Ile Gln Asn Asp Gly Phe Gln Phe Val Thr 
        435                 440                 445             


Glu Leu Gln Glu Asp Phe Leu Gly Gly Asn Gly Phe Ile Gly Gln Glu 
    450                 455                 460                 


Leu Asn Ser Gly Arg Glu Ser Pro Phe Val Lys Thr Glu Asp Asn Gly 
465                 470                 475                 480 


Ser Asp Tyr Leu Val Tyr Leu Pro Ser Gln Met Phe Glu Pro Gln Lys 
                485                 490                 495     


Leu Met Ile Asn Tyr Glu Lys Asp Gln Lys Ser Ala Glu Ile Ala Ser 
            500                 505                 510         


Leu Thr Ser Gly His Glu Asn Tyr Gly Arg Lys Glu Glu Pro Asp His 
        515                 520                 525             


Thr Tyr Glu Pro Gly Asp Val Ser Leu Gln Glu Tyr Tyr Met Asp Val 
    530                 535                 540                 


Ala Phe Leu Ile Asp Ala Ser Gln Arg Val Gly Ser Asp Glu Phe Lys 
545                 550                 555                 560 


Glu Val Lys Ala Phe Ile Thr Ser Val Leu Asp Tyr Phe His Ile Ala 
                565                 570                 575     


Pro Thr Pro Leu Thr Ser Thr Leu Gly Asp Arg Val Ala Val Leu Ser 
            580                 585                 590         


Tyr Ser Pro Pro Gly Tyr Met Pro Asn Thr Glu Glu Cys Pro Val Tyr 
        595                 600                 605             


Leu Glu Phe Asp Leu Val Thr Tyr Asn Ser Ile His Gln Met Lys His 
    610                 615                 620                 


His Leu Gln Asp Ser Gln Gln Leu Asn Gly Asp Val Phe Ile Gly His 
625                 630                 635                 640 


Ala Leu Gln Trp Thr Ile Asp Asn Val Phe Val Gly Thr Pro Asn Leu 
                645                 650                 655     


Arg Lys Asn Lys Val Ile Phe Val Ile Ser Ala Gly Glu Thr Asn Ser 
            660                 665                 670         


Leu Asp Lys Asp Val Leu Arg Asn Val Ser Leu Arg Ala Lys Cys Gln 
        675                 680                 685             


Gly Tyr Ser Ile Phe Val Phe Ser Phe Gly Pro Lys His Asn Asp Lys 
    690                 695                 700                 


Glu Leu Glu Glu Leu Ala Ser His Pro Leu Asp His His Leu Val Gln 
705                 710                 715                 720 


Leu Gly Arg Thr His Lys Pro Asp Trp Asn Tyr Ile Ile Lys Phe Val 
                725                 730                 735     


Lys Pro Phe Val His Leu Ile Arg Arg Ala Ile Asn Lys Tyr Pro Thr 
            740                 745                 750         


Glu Asp Met Lys Ala Thr Cys Val Asn Met Thr Ser Pro Asn Pro Glu 
        755                 760                 765             


Asn Gly Gly Thr Glu Asn Thr Val Leu Trp 
    770                 775             


<210>  3343
<211>  2263
<212>  PRT
<213>  Homo Sapiens

<400>  3343

Met Met Leu Leu Ile Leu Phe Leu Val Ile Ile Cys Ser His Ile Ser 
1               5                   10                  15      


Val Asn Gln Asp Ser Gly Pro Glu Tyr Ala Asp Val Val Phe Leu Val 
            20                  25                  30          


Asp Ser Ser Asp Arg Leu Gly Ser Lys Ser Phe Pro Phe Val Lys Met 
        35                  40                  45              


Phe Ile Thr Lys Met Ile Ser Ser Leu Pro Ile Glu Ala Asp Lys Tyr 
    50                  55                  60                  


Arg Val Ala Leu Ala Gln Tyr Ser Asp Lys Leu His Ser Glu Phe His 
65                  70                  75                  80  


Leu Ser Thr Phe Lys Gly Arg Ser Pro Met Leu Asn His Leu Arg Lys 
                85                  90                  95      


Asn Phe Gly Phe Ile Gly Gly Ser Leu Gln Ile Gly Lys Ala Leu Gln 
            100                 105                 110         


Glu Ala His Arg Thr Tyr Phe Ser Ala Pro Ala Asn Gly Arg Asp Lys 
        115                 120                 125             


Lys Gln Phe Pro Pro Ile Leu Val Val Leu Ala Ser Ser Glu Ser Glu 
    130                 135                 140                 


Asp Asn Val Glu Glu Ala Ser Lys Ala Leu Arg Lys Asp Gly Val Lys 
145                 150                 155                 160 


Ile Ile Ser Val Gly Val Gln Lys Ala Ser Glu Glu Asn Leu Lys Ala 
                165                 170                 175     


Met Ala Thr Ser Gln Phe His Phe Asn Leu Arg Thr Val Arg Asp Leu 
            180                 185                 190         


Ser Met Phe Ser Gln Asn Met Thr His Ile Ile Lys Asp Val Ile Lys 
        195                 200                 205             


Tyr Lys Glu Gly Ala Val Asp Asp Ile Phe Val Glu Ala Cys Gln Gly 
    210                 215                 220                 


Pro Ser Met Ala Asp Val Val Phe Leu Leu Asp Met Ser Ile Asn Gly 
225                 230                 235                 240 


Ser Glu Glu Asn Phe Asp Tyr Leu Lys Gly Phe Leu Glu Glu Ser Val 
                245                 250                 255     


Ser Ala Leu Asp Ile Lys Glu Asn Cys Met Arg Val Gly Leu Val Ala 
            260                 265                 270         


Tyr Ser Asn Glu Thr Lys Val Ile Asn Ser Leu Ser Met Gly Ile Asn 
        275                 280                 285             


Lys Ser Glu Val Leu Gln His Ile Gln Asn Leu Ser Pro Arg Thr Gly 
    290                 295                 300                 


Lys Ala Tyr Thr Gly Ala Ala Ile Lys Lys Leu Arg Lys Glu Val Phe 
305                 310                 315                 320 


Ser Ala Arg Asn Gly Ser Arg Lys Asn Gln Gly Val Pro Gln Ile Ala 
                325                 330                 335     


Val Leu Val Thr His Arg Asp Ser Glu Asp Asn Val Thr Lys Ala Ala 
            340                 345                 350         


Val Asn Leu Arg Arg Glu Gly Val Thr Ile Phe Thr Leu Gly Ile Glu 
        355                 360                 365             


Gly Ala Ser Asp Thr Gln Leu Glu Lys Ile Ala Ser His Pro Ala Glu 
    370                 375                 380                 


Gln Tyr Val Ser Lys Leu Lys Thr Phe Ala Asp Leu Ala Ala His Asn 
385                 390                 395                 400 


Gln Thr Phe Leu Lys Lys Leu Arg Asn Gln Ile Thr His Thr Val Ser 
                405                 410                 415     


Val Phe Ser Glu Arg Thr Glu Thr Leu Lys Ser Gly Cys Val Asp Thr 
            420                 425                 430         


Glu Glu Ala Asp Ile Tyr Leu Leu Ile Asp Gly Ser Gly Ser Thr Gln 
        435                 440                 445             


Ala Thr Asp Phe His Glu Met Lys Thr Phe Leu Ser Glu Val Val Gly 
    450                 455                 460                 


Met Phe Asn Ile Ala Pro His Lys Val Arg Val Gly Ala Val Gln Tyr 
465                 470                 475                 480 


Ala Asp Ser Trp Asp Leu Glu Phe Glu Ile Asn Lys Tyr Ser Asn Lys 
                485                 490                 495     


Gln Asp Leu Gly Lys Ala Ile Glu Asn Ile Arg Gln Met Gly Gly Asn 
            500                 505                 510         


Thr Asn Thr Gly Ala Ala Leu Asn Phe Thr Leu Ser Leu Leu Gln Lys 
        515                 520                 525             


Ala Lys Lys Gln Arg Gly Asn Lys Val Pro Cys His Leu Val Val Leu 
    530                 535                 540                 


Thr Asn Gly Met Ser Lys Asp Ser Ile Leu Glu Pro Ala Asn Arg Leu 
545                 550                 555                 560 


Arg Glu Glu His Ile Arg Val Tyr Ala Ile Gly Ile Lys Glu Ala Asn 
                565                 570                 575     


Gln Thr Gln Leu Arg Glu Ile Ala Gly Glu Glu Lys Arg Val Tyr Tyr 
            580                 585                 590         


Val His Asp Phe Asp Ala Leu Lys Asp Ile Arg Asn Gln Val Val Gln 
        595                 600                 605             


Glu Ile Cys Thr Glu Glu Ala Cys Lys Glu Met Lys Ala Asp Ile Met 
    610                 615                 620                 


Phe Leu Val Asp Ser Ser Gly Ser Ile Gly Pro Glu Asn Phe Ser Lys 
625                 630                 635                 640 


Met Lys Thr Phe Met Lys Asn Leu Val Ser Lys Ser Gln Ile Gly Pro 
                645                 650                 655     


Asp Arg Val Gln Ile Gly Val Val Gln Phe Ser Asp Ile Asn Lys Glu 
            660                 665                 670         


Glu Phe Gln Leu Asn Arg Phe Met Ser Gln Ser Asp Ile Ser Asn Ala 
        675                 680                 685             


Ile Asp Gln Met Ala His Ile Gly Gln Thr Thr Leu Thr Gly Ser Ala 
    690                 695                 700                 


Leu Ser Phe Val Ser Gln Tyr Phe Ser Pro Thr Lys Gly Ala Arg Pro 
705                 710                 715                 720 


Asn Ile Arg Lys Phe Leu Ile Leu Ile Thr Asp Gly Glu Ala Gln Asp 
                725                 730                 735     


Ile Val Lys Glu Pro Ala Val Val Leu Arg Gln Glu Gly Val Ile Ile 
            740                 745                 750         


Tyr Ser Val Gly Val Phe Gly Ser Asn Val Thr Gln Leu Glu Glu Ile 
        755                 760                 765             


Ser Gly Arg Pro Glu Met Val Phe Tyr Val Glu Asn Phe Asp Ile Leu 
    770                 775                 780                 


Gln Arg Ile Glu Asp Asp Leu Val Phe Gly Ile Cys Ser Pro Arg Glu 
785                 790                 795                 800 


Glu Cys Lys Arg Ile Glu Val Leu Asp Val Val Phe Val Ile Asp Ser 
                805                 810                 815     


Ser Gly Ser Ile Asp Tyr Asp Glu Tyr Asn Ile Met Lys Asp Phe Met 
            820                 825                 830         


Ile Gly Leu Val Lys Lys Ala Asp Val Gly Lys Asn Gln Val Arg Phe 
        835                 840                 845             


Gly Ala Leu Lys Tyr Ala Asp Asp Pro Glu Val Leu Phe Tyr Leu Asp 
    850                 855                 860                 


Asp Phe Gly Thr Lys Leu Glu Val Ile Ser Val Leu Gln Asn Asp Gln 
865                 870                 875                 880 


Ala Met Gly Gly Ser Thr Tyr Thr Ala Glu Ala Leu Gly Phe Ser Asp 
                885                 890                 895     


His Met Phe Thr Glu Ala Arg Gly Ser Arg Leu Asn Lys Gly Val Pro 
            900                 905                 910         


Gln Val Leu Ile Val Ile Thr Asp Gly Glu Ser His Asp Ala Asp Lys 
        915                 920                 925             


Leu Asn Ala Thr Ala Lys Ala Leu Arg Asp Lys Gly Ile Leu Val Leu 
    930                 935                 940                 


Ala Val Gly Ile Asp Gly Ala Asn Pro Val Glu Leu Leu Ala Met Ala 
945                 950                 955                 960 


Gly Ser Ser Asp Lys Tyr Phe Phe Val Glu Thr Phe Gly Gly Leu Lys 
                965                 970                 975     


Gly Ile Phe Ser Asp Val Thr Ala Ser Val Cys Asn Ser Ser Lys Val 
            980                 985                 990         


Asp Cys Glu Ile Asp Lys Val Asp  Leu Val Phe Leu Met  Asp Gly Ser 
        995                 1000                 1005             


Thr Ser  Ile Gln Pro Asn Asp  Phe Lys Lys Met Lys  Glu Phe Leu 
    1010                 1015                 1020             


Ala Ser  Val Val Gln Asp Phe  Asp Val Ser Leu Asn  Arg Val Arg 
    1025                 1030                 1035             


Ile Gly  Ala Ala Gln Phe Ser  Asp Thr Tyr His Pro  Glu Phe Pro 
    1040                 1045                 1050             


Leu Gly  Thr Phe Ile Gly Glu  Lys Glu Ile Ser Phe  Gln Ile Glu 
    1055                 1060                 1065             


Asn Ile  Lys Gln Ile Phe Gly  Asn Thr His Ile Gly  Ala Ala Leu 
    1070                 1075                 1080             


Arg Glu  Val Glu His Tyr Phe  Arg Pro Asp Met Gly  Ser Arg Ile 
    1085                 1090                 1095             


Asn Thr  Gly Thr Pro Gln Val  Leu Leu Val Leu Thr  Asp Gly Gln 
    1100                 1105                 1110             


Ser Gln  Asp Glu Val Ala Gln  Ala Ala Glu Ala Leu  Arg His Arg 
    1115                 1120                 1125             


Gly Ile  Asp Ile Tyr Ser Val  Gly Ile Gly Asp Val  Asp Asp Gln 
    1130                 1135                 1140             


Gln Leu  Ile Gln Ile Thr Gly  Thr Ala Glu Lys Lys  Leu Thr Val 
    1145                 1150                 1155             


His Asn  Phe Asp Glu Leu Lys  Lys Val Asn Lys Arg  Ile Val Arg 
    1160                 1165                 1170             


Asn Ile  Cys Thr Thr Ala Gly  Glu Ser Asn Cys Phe  Val Asp Val 
    1175                 1180                 1185             


Val Val  Gly Phe Asp Val Ser  Thr Gln Glu Lys Gly  Gln Thr Leu 
    1190                 1195                 1200             


Leu Glu  Gly Gln Pro Trp Met  Glu Thr Tyr Leu Gln  Asp Ile Leu 
    1205                 1210                 1215             


Arg Ala  Ile Ser Ser Leu Asn  Gly Val Ser Cys Glu  Val Gly Thr 
    1220                 1225                 1230             


Glu Thr  Gln Val Ser Val Ala  Phe Gln Val Thr Asn  Ala Met Glu 
    1235                 1240                 1245             


Lys Tyr  Ser Pro Lys Phe Glu  Ile Tyr Ser Glu Asn  Ile Leu Asn 
    1250                 1255                 1260             


Ser Leu  Lys Asp Ile Thr Val  Lys Gly Pro Ser Leu  Leu Asn Ala 
    1265                 1270                 1275             


Asn Leu  Leu Asp Ser Leu Trp  Asp Thr Phe Gln Asn  Lys Ser Ala 
    1280                 1285                 1290             


Ala Arg  Gly Lys Val Val Leu  Leu Phe Ser Asp Gly  Leu Asp Asp 
    1295                 1300                 1305             


Asp Val  Glu Lys Leu Glu Gln  Lys Ser Asp Glu Leu  Arg Lys Glu 
    1310                 1315                 1320             


Gly Leu  Asn Ala Leu Ile Thr  Val Ala Leu Asp Gly  Pro Ala Asp 
    1325                 1330                 1335             


Ser Ser  Asp Leu Ala Asp Leu  Pro Tyr Ile Glu Phe  Gly Lys Gly 
    1340                 1345                 1350             


Phe Glu  Tyr Arg Thr Gln Leu  Ser Ile Gly Met Arg  Glu Leu Gly 
    1355                 1360                 1365             


Ser Arg  Leu Ser Lys Gln Leu  Val Asn Val Ala Glu  Arg Thr Cys 
    1370                 1375                 1380             


Cys Cys  Leu Phe Cys Lys Cys  Ile Gly Gly Asp Gly  Thr Met Gly 
    1385                 1390                 1395             


Asp Pro  Gly Pro Pro Gly Lys  Arg Gly Pro Pro Gly  Phe Lys Gly 
    1400                 1405                 1410             


Ser Glu  Gly Tyr Leu Gly Glu  Glu Gly Ile Ala Gly  Glu Arg Gly 
    1415                 1420                 1425             


Ala Pro  Gly Pro Val Gly Glu  Gln Gly Thr Lys Gly  Cys Tyr Gly 
    1430                 1435                 1440             


Thr Lys  Gly Pro Lys Gly Asn  Arg Gly Leu Asn Gly  Gln Glu Gly 
    1445                 1450                 1455             


Glu Val  Gly Glu Asn Gly Ile  Asp Gly Leu Asn Gly  Glu Gln Gly 
    1460                 1465                 1470             


Asp Asn  Gly Leu Pro Gly Arg  Lys Gly Glu Lys Gly  Asp Glu Gly 
    1475                 1480                 1485             


Ser Gln  Gly Ser Pro Gly Lys  Arg Gly Thr Pro Gly  Asp Arg Gly 
    1490                 1495                 1500             


Ala Lys  Gly Leu Arg Gly Asp  Pro Gly Ala Pro Gly  Val Asp Ser 
    1505                 1510                 1515             


Ser Ile  Glu Gly Pro Thr Gly  Leu Lys Gly Glu Arg  Gly Arg Gln 
    1520                 1525                 1530             


Gly Arg  Arg Gly Trp Pro Gly  Pro Pro Gly Thr Pro  Gly Ser Arg 
    1535                 1540                 1545             


Arg Lys  Thr Ala Ala His Gly  Arg Arg Gly His Thr  Gly Pro Gln 
    1550                 1555                 1560             


Gly Thr  Ala Gly Ile Pro Gly  Pro Asp Gly Leu Glu  Gly Ser Leu 
    1565                 1570                 1575             


Gly Leu  Lys Gly Pro Gln Gly  Pro Arg Gly Glu Ala  Gly Val Lys 
    1580                 1585                 1590             


Gly Glu  Lys Gly Gly Val Gly  Ser Lys Gly Pro Gln  Gly Pro Pro 
    1595                 1600                 1605             


Gly Pro  Gly Gly Glu Ala Gly  Asn Gln Gly Arg Leu  Gly Ser Gln 
    1610                 1615                 1620             


Gly Asn  Lys Gly Glu Pro Gly  Asp Leu Gly Glu Lys  Gly Ala Val 
    1625                 1630                 1635             


Gly Phe  Pro Gly Pro Arg Gly  Leu Gln Gly Asn Asp  Gly Ser Pro 
    1640                 1645                 1650             


Gly Tyr  Gly Ser Val Gly Arg  Lys Gly Ala Lys Gly  Gln Glu Gly 
    1655                 1660                 1665             


Phe Pro  Gly Glu Ser Gly Pro  Lys Gly Glu Ile Gly  Asp Pro Gly 
    1670                 1675                 1680             


Gly Pro  Gly Glu Thr Gly Leu  Lys Gly Ala Arg Gly  Lys Met Ile 
    1685                 1690                 1695             


Ser Ala  Gly Leu Pro Gly Glu  Met Gly Ser Pro Gly  Glu Pro Gly 
    1700                 1705                 1710             


Pro Pro  Gly Arg Lys Gly Val  Lys Gly Ala Lys Gly  Leu Ala Ser 
    1715                 1720                 1725             


Phe Ser  Thr Cys Glu Leu Ile  Gln Tyr Val Arg Asp  Arg Ser Pro 
    1730                 1735                 1740             


Gly Arg  His Gly Lys Pro Glu  Cys Pro Val His Pro  Thr Glu Leu 
    1745                 1750                 1755             


Val Phe  Ala Leu Asp His Ser  Arg Asp Val Thr Glu  Gln Glu Phe 
    1760                 1765                 1770             


Glu Arg  Met Lys Glu Met Met  Ala Phe Leu Val Arg  Asp Ile Lys 
    1775                 1780                 1785             


Val Arg  Glu Asn Ser Cys Pro  Val Gly Ala His Ile  Ala Ile Leu 
    1790                 1795                 1800             


Ser Tyr  Asn Ser His Ala Arg  His Leu Val Arg Phe  Ser Asp Ala 
    1805                 1810                 1815             


Tyr Lys  Lys Ser Gln Leu Leu  Arg Glu Ile Glu Thr  Ile Pro Tyr 
    1820                 1825                 1830             


Glu Arg  Ser Ser Ala Ser Arg  Glu Ile Gly Arg Ala  Met Arg Phe 
    1835                 1840                 1845             


Ile Ser  Arg Asn Val Phe Lys  Arg Thr Leu Pro Gly  Ala His Thr 
    1850                 1855                 1860             


Arg Lys  Ile Ala Thr Phe Phe  Ser Ser Gly Gln Ser  Ala Asp Ala 
    1865                 1870                 1875             


His Ser  Ile Thr Thr Ala Ala  Met Glu Phe Gly Ala  Leu Glu Ile 
    1880                 1885                 1890             


Ile Pro  Val Val Ile Thr Phe  Ser Asn Val Pro Ser  Val Arg Arg 
    1895                 1900                 1905             


Ala Phe  Ala Ile Asp Asp Thr  Gly Thr Phe Gln Val  Ile Val Val 
    1910                 1915                 1920             


Pro Ser  Gly Ala Asp Tyr Ile  Pro Ala Leu Glu Arg  Leu Gln Arg 
    1925                 1930                 1935             


Cys Thr  Phe Cys Tyr Asp Val  Cys Lys Pro Asp Ala  Ser Cys Asp 
    1940                 1945                 1950             


Gln Ala  Arg Pro Pro Pro Val  Gln Ser Tyr Met Asp  Ala Ala Phe 
    1955                 1960                 1965             


Leu Leu  Asp Ala Ser Arg Asn  Met Gly Ser Ala Glu  Phe Glu Asp 
    1970                 1975                 1980             


Ile Arg  Ala Phe Leu Gly Ala  Leu Leu Asp His Phe  Glu Ile Thr 
    1985                 1990                 1995             


Pro Glu  Pro Glu Thr Ser Val  Thr Gly Asp Arg Val  Ala Leu Leu 
    2000                 2005                 2010             


Ser His  Ala Pro Pro Asp Phe  Leu Pro Asn Thr Gln  Lys Ser Pro 
    2015                 2020                 2025             


Val Arg  Ala Glu Phe Asn Leu  Thr Thr Tyr Arg Ser  Lys Arg Leu 
    2030                 2035                 2040             


Met Lys  Arg His Val His Glu  Ser Val Lys Gln Leu  Asn Gly Asp 
    2045                 2050                 2055             


Ala Phe  Ile Gly His Ala Leu  Gln Trp Thr Leu Asp  Asn Val Phe 
    2060                 2065                 2070             


Leu Ser  Thr Pro Asn Leu Arg  Arg Asn Lys Val Ile  Phe Val Ile 
    2075                 2080                 2085             


Ser Ala  Gly Glu Thr Ser His  Leu Asp Gly Glu Ile  Leu Lys Lys 
    2090                 2095                 2100             


Glu Ser  Leu Arg Ala Lys Cys  Gln Gly Tyr Ala Leu  Phe Val Phe 
    2105                 2110                 2115             


Ser Leu  Gly Pro Ile Trp Asp  Asp Lys Glu Leu Glu  Asp Leu Ala 
    2120                 2125                 2130             


Ser His  Pro Leu Asp His His  Leu Val Gln Leu Gly  Arg Ile His 
    2135                 2140                 2145             


Lys Pro  Asp His Ser Tyr Gly  Val Lys Phe Val Lys  Ser Phe Ile 
    2150                 2155                 2160             


Asn Ser  Ile Arg Arg Ala Ile  Asn Lys Tyr Pro Pro  Ile Asn Leu 
    2165                 2170                 2175             


Lys Ile  Lys Cys Asn Arg Leu  Asn Ser Ile Asp Pro  Lys Gln Pro 
    2180                 2185                 2190             


Pro Arg  Pro Phe Arg Ser Phe  Val Pro Gly Pro Leu  Lys Ala Thr 
    2195                 2200                 2205             


Leu Lys  Glu Asp Val Leu Gln  Lys Ala Lys Phe Phe  Gln Asp Lys 
    2210                 2215                 2220             


Lys Tyr  Leu Ser Arg Val Ala  Arg Ser Gly Arg Asp  Asp Ala Ile 
    2225                 2230                 2235             


Gln Asn  Phe Met Arg Ser Thr  Ser His Thr Phe Lys  Asn Gly Arg 
    2240                 2245                 2250             


Met Ile  Glu Ser Ala Pro Lys  Gln His Asp 
    2255                 2260             


<210>  3344
<211>  298
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3344

Xaa Leu Asn Gly Val Ser Cys Glu Val Gly Thr Glu Thr Gln Val Ser 
1               5                   10                  15      


Val Ala Phe Gln Val Thr Asn Ala Met Glu Lys Tyr Ser Pro Lys Phe 
            20                  25                  30          


Glu Ile Tyr Ser Glu Asn Ile Leu Asn Ser Leu Lys Asp Ile Thr Val 
        35                  40                  45              


Lys Gly Pro Ser Leu Leu Asn Ala Asn Leu Leu Asp Ser Leu Trp Asp 
    50                  55                  60                  


Thr Phe Gln Asn Lys Ser Ala Ala Arg Gly Lys Val Val Leu Leu Phe 
65                  70                  75                  80  


Ser Asp Gly Leu Asp Asp Asp Val Glu Lys Leu Glu Gln Lys Ser Asp 
                85                  90                  95      


Glu Leu Arg Lys Glu Gly Leu Asn Ala Leu Ile Thr Val Ala Leu Asp 
            100                 105                 110         


Gly Pro Ala Asp Ser Ser Asp Leu Ala Asp Leu Pro Tyr Ile Glu Phe 
        115                 120                 125             


Gly Lys Gly Phe Glu Tyr Arg Thr Gln Leu Ser Ile Gly Met Arg Glu 
    130                 135                 140                 


Leu Gly Ser Arg Leu Ser Lys Gln Leu Val Asn Val Ala Glu Arg Thr 
145                 150                 155                 160 


Cys Cys Cys Leu Phe Cys Lys Cys Ile Gly Gly Asp Gly Thr Met Gly 
                165                 170                 175     


Asp Pro Gly Pro Pro Gly Lys Arg Gly Pro Pro Gly Phe Lys Gly Ser 
            180                 185                 190         


Glu Gly Tyr Leu Gly Glu Glu Gly Ile Ala Gly Glu Arg Gly Ala Pro 
        195                 200                 205             


Gly Pro Val Gly Glu Gln Gly Thr Lys Gly Cys Tyr Gly Thr Lys Gly 
    210                 215                 220                 


Pro Lys Gly Asn Arg Gly Leu Asn Gly Gln Glu Gly Glu Val Gly Glu 
225                 230                 235                 240 


Asn Gly Ile Asp Gly Leu Asn Gly Glu Gln Gly Asp Asn Gly Leu Pro 
                245                 250                 255     


Gly Arg Lys Gly Glu Lys Gly Asp Glu Gly Ser Gln Gly Ser Pro Gly 
            260                 265                 270         


Lys Arg Gly Thr Pro Gly Asp Arg Gly Ala Lys Gly Leu Arg Gly Asp 
        275                 280                 285             


Pro Val Ser Ala Arg Ala Ala Asn Trp Ser 
    290                 295             


<210>  3345
<211>  259
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3345

Xaa Thr Asn Ala Met Glu Lys Tyr Ser Pro Lys Phe Glu Ile Tyr Ser 
1               5                   10                  15      


Glu Asn Ile Leu Asn Ser Leu Lys Asp Ile Thr Val Lys Gly Pro Ser 
            20                  25                  30          


Leu Leu Asn Ala Asn Leu Leu Asp Ser Leu Trp Asp Thr Phe Gln Asn 
        35                  40                  45              


Lys Ser Ala Ala Arg Gly Lys Val Val Leu Leu Phe Ser Asp Gly Leu 
    50                  55                  60                  


Asp Asp Asp Val Glu Lys Leu Glu Gln Lys Ser Asp Glu Leu Arg Lys 
65                  70                  75                  80  


Glu Gly Leu Asn Ala Leu Ile Thr Val Ala Leu Asp Gly Pro Ala Asp 
                85                  90                  95      


Ser Ser Asp Leu Ala Asp Leu Pro Tyr Ile Glu Phe Gly Lys Gly Phe 
            100                 105                 110         


Glu Tyr Arg Thr Gln Leu Ser Ile Gly Met Arg Glu Leu Gly Ser Arg 
        115                 120                 125             


Leu Ser Lys Gln Leu Val Asn Val Ala Glu Arg Thr Cys Cys Cys Leu 
    130                 135                 140                 


Phe Cys Lys Cys Ile Gly Gly Asp Gly Thr Met Gly Asp Pro Gly Pro 
145                 150                 155                 160 


Pro Gly Lys Arg Leu His Val Lys Arg Val Val Asp Phe Phe Lys Lys 
                165                 170                 175     


Gln Gly Ser Glu Arg Met Glu Arg Lys Gly Pro Pro Gly Phe Lys Gly 
            180                 185                 190         


Ser Glu Gly Tyr Leu Gly Glu Glu Gly Ile Ala Gly Glu Arg Gly Ala 
        195                 200                 205             


Pro Gly Pro Val Gly Glu Gln Gly Thr Lys Gly Cys Tyr Gly Thr Lys 
    210                 215                 220                 


Gly Pro Lys Gly Asn Arg Gly Leu Asn Gly Gln Glu Gly Glu Val Gly 
225                 230                 235                 240 


Glu Asn Gly Ile Asp Gly Leu Asn Gly Glu Gln Gly Asp Asn Gly Leu 
                245                 250                 255     


Pro Gly Arg 
            


<210>  3346
<211>  173
<212>  PRT
<213>  Homo Sapiens

<400>  3346

Met Ser Ala Leu Ala Cys Gly Leu Pro Val Pro Val Pro Cys Leu Asn 
1               5                   10                  15      


Ser His Leu Ser Met Gly Gln Lys Gly Ala Pro Gly Pro Lys Gly Phe 
            20                  25                  30          


Lys Gly Asp Pro Gly Val Gly Val Pro Gly Ser Pro Gly Pro Pro Gly 
        35                  40                  45              


Pro Pro Gly Val Lys Gly Asp Leu Gly Leu Pro Gly Leu Pro Gly Ala 
    50                  55                  60                  


Pro Gly Val Val Gly Phe Pro Gly Gln Thr Gly Pro Arg Gly Glu Met 
65                  70                  75                  80  


Gly Gln Pro Gly Pro Ser Gly Glu Arg Gly Leu Ala Gly Pro Pro Gly 
                85                  90                  95      


Arg Glu Gly Ile Pro Gly Pro Leu Gly Pro Pro Gly Pro Pro Gly Ser 
            100                 105                 110         


Val Gly Pro Pro Gly Ala Ser Gly Leu Lys Gly Asp Lys Gly Asp Pro 
        115                 120                 125             


Gly Val Gly Leu Pro Gly Pro Arg Gly Glu Arg Gly Glu Pro Gly Ile 
    130                 135                 140                 


Arg Gly Glu Asp Gly Arg Pro Gly Gln Glu Gly Pro Arg Gly Leu Thr 
145                 150                 155                 160 


Gly Pro Pro Gly Ser Arg Gly Glu Arg Gly Glu Lys Gly 
                165                 170             


<210>  3347
<211>  2944
<212>  PRT
<213>  Homo Sapiens

<400>  3347

Met Thr Leu Arg Leu Leu Val Ala Ala Leu Cys Ala Gly Ile Leu Ala 
1               5                   10                  15      


Glu Ala Pro Arg Val Arg Ala Gln His Arg Glu Arg Val Thr Cys Thr 
            20                  25                  30          


Arg Leu Tyr Ala Ala Asp Ile Val Phe Leu Leu Asp Gly Ser Ser Ser 
        35                  40                  45              


Ile Gly Arg Ser Asn Phe Arg Glu Val Arg Ser Phe Leu Glu Gly Leu 
    50                  55                  60                  


Val Leu Pro Phe Ser Gly Ala Ala Ser Ala Gln Gly Val Arg Phe Ala 
65                  70                  75                  80  


Thr Val Gln Tyr Ser Asp Asp Pro Arg Thr Glu Phe Gly Leu Asp Ala 
                85                  90                  95      


Leu Gly Ser Gly Gly Asp Val Ile Arg Ala Ile Arg Glu Leu Ser Tyr 
            100                 105                 110         


Lys Gly Gly Asn Thr Arg Thr Gly Ala Ala Ile Leu His Val Ala Asp 
        115                 120                 125             


His Val Phe Leu Pro Gln Leu Ala Arg Pro Gly Val Pro Lys Val Cys 
    130                 135                 140                 


Ile Leu Ile Thr Asp Gly Lys Ser Gln Asp Leu Val Asp Thr Ala Ala 
145                 150                 155                 160 


Gln Arg Leu Lys Gly Gln Gly Val Lys Leu Phe Ala Val Gly Ile Lys 
                165                 170                 175     


Asn Ala Asp Pro Glu Glu Leu Lys Arg Val Ala Ser Gln Pro Thr Ser 
            180                 185                 190         


Asp Phe Phe Phe Phe Val Asn Asp Phe Ser Ile Leu Arg Thr Leu Leu 
        195                 200                 205             


Pro Leu Val Ser Arg Arg Val Cys Thr Thr Ala Gly Gly Val Pro Val 
    210                 215                 220                 


Thr Arg Pro Pro Asp Asp Ser Thr Ser Ala Pro Arg Asp Leu Val Leu 
225                 230                 235                 240 


Ser Glu Pro Ser Ser Gln Ser Leu Arg Val Gln Trp Thr Ala Ala Ser 
                245                 250                 255     


Gly Pro Val Thr Gly Tyr Lys Val Gln Tyr Thr Pro Leu Thr Gly Leu 
            260                 265                 270         


Gly Gln Pro Leu Pro Ser Glu Arg Gln Glu Val Asn Val Pro Ala Gly 
        275                 280                 285             


Glu Thr Ser Val Arg Leu Arg Gly Leu Arg Pro Leu Thr Glu Tyr Gln 
    290                 295                 300                 


Val Thr Val Ile Ala Leu Tyr Ala Asn Ser Ile Gly Glu Ala Val Ser 
305                 310                 315                 320 


Gly Thr Ala Arg Thr Thr Ala Leu Glu Gly Pro Glu Leu Thr Ile Gln 
                325                 330                 335     


Asn Thr Thr Ala His Ser Leu Leu Val Ala Trp Arg Ser Val Pro Gly 
            340                 345                 350         


Ala Thr Gly Tyr Arg Val Thr Trp Arg Val Leu Ser Gly Gly Pro Thr 
        355                 360                 365             


Gln Gln Gln Glu Leu Gly Pro Gly Gln Gly Ser Val Leu Leu Arg Asp 
    370                 375                 380                 


Leu Glu Pro Gly Thr Asp Tyr Glu Val Thr Val Ser Thr Leu Phe Gly 
385                 390                 395                 400 


Arg Ser Val Gly Pro Ala Thr Ser Leu Met Ala Arg Thr Asp Ala Ser 
                405                 410                 415     


Val Glu Gln Thr Leu Arg Pro Val Ile Leu Gly Pro Thr Ser Ile Leu 
            420                 425                 430         


Leu Ser Trp Asn Leu Val Pro Glu Ala Arg Gly Tyr Arg Leu Glu Trp 
        435                 440                 445             


Arg Arg Glu Thr Gly Leu Glu Pro Pro Gln Lys Val Val Leu Pro Ser 
    450                 455                 460                 


Asp Val Thr Arg Tyr Gln Leu Asp Gly Leu Gln Pro Gly Thr Glu Tyr 
465                 470                 475                 480 


Arg Leu Thr Leu Tyr Thr Leu Leu Glu Gly His Glu Val Ala Thr Pro 
                485                 490                 495     


Ala Thr Val Val Pro Thr Gly Pro Glu Leu Pro Val Ser Pro Val Thr 
            500                 505                 510         


Asp Leu Gln Ala Thr Glu Leu Pro Gly Gln Arg Val Arg Val Ser Trp 
        515                 520                 525             


Ser Pro Val Pro Gly Ala Thr Gln Tyr Arg Ile Ile Val Arg Ser Thr 
    530                 535                 540                 


Gln Gly Val Glu Arg Thr Leu Val Leu Pro Gly Ser Gln Thr Ala Phe 
545                 550                 555                 560 


Asp Leu Asp Asp Val Gln Ala Gly Leu Ser Tyr Thr Val Arg Val Ser 
                565                 570                 575     


Ala Arg Val Gly Pro Arg Glu Gly Ser Ala Ser Val Leu Thr Val Arg 
            580                 585                 590         


Arg Glu Pro Glu Thr Pro Leu Ala Val Pro Gly Leu Arg Val Val Val 
        595                 600                 605             


Ser Asp Ala Thr Arg Val Arg Val Ala Trp Gly Pro Val Pro Gly Ala 
    610                 615                 620                 


Ser Gly Phe Arg Ile Ser Trp Ser Thr Gly Ser Gly Pro Glu Ser Ser 
625                 630                 635                 640 


Gln Thr Leu Pro Pro Asp Ser Thr Ala Thr Asp Ile Thr Gly Leu Gln 
                645                 650                 655     


Pro Gly Thr Thr Tyr Gln Val Ala Val Ser Val Leu Arg Gly Arg Glu 
            660                 665                 670         


Glu Gly Pro Ala Ala Val Ile Val Ala Arg Thr Asp Pro Leu Gly Pro 
        675                 680                 685             


Val Arg Thr Val His Val Thr Gln Ala Ser Ser Ser Ser Val Thr Ile 
    690                 695                 700                 


Thr Trp Thr Arg Val Pro Gly Ala Thr Gly Tyr Arg Val Ser Trp His 
705                 710                 715                 720 


Ser Ala His Gly Pro Glu Lys Ser Gln Leu Val Ser Gly Glu Ala Thr 
                725                 730                 735     


Val Ala Glu Leu Asp Gly Leu Glu Pro Asp Thr Glu Tyr Thr Val His 
            740                 745                 750         


Val Arg Ala His Val Ala Gly Val Asp Gly Pro Pro Ala Ser Val Val 
        755                 760                 765             


Val Arg Thr Ala Pro Glu Pro Val Gly Arg Val Ser Arg Leu Gln Ile 
    770                 775                 780                 


Leu Asn Ala Ser Ser Asp Val Leu Arg Ile Thr Trp Val Gly Val Thr 
785                 790                 795                 800 


Gly Ala Thr Ala Tyr Arg Leu Ala Trp Gly Arg Ser Glu Gly Gly Pro 
                805                 810                 815     


Met Arg His Gln Ile Leu Pro Gly Asn Thr Asp Ser Ala Glu Ile Arg 
            820                 825                 830         


Gly Leu Glu Gly Gly Val Ser Tyr Ser Val Arg Val Thr Ala Leu Val 
        835                 840                 845             


Gly Asp Arg Glu Gly Thr Pro Val Ser Ile Val Val Thr Thr Pro Pro 
    850                 855                 860                 


Glu Ala Pro Pro Ala Leu Gly Thr Leu His Val Val Gln Arg Gly Glu 
865                 870                 875                 880 


His Ser Leu Arg Leu Arg Trp Glu Pro Val Pro Arg Ala Gln Gly Phe 
                885                 890                 895     


Leu Leu His Trp Gln Pro Glu Gly Gly Gln Glu Gln Ser Arg Val Leu 
            900                 905                 910         


Gly Pro Glu Leu Ser Ser Tyr His Leu Asp Gly Leu Glu Pro Ala Thr 
        915                 920                 925             


Gln Tyr Arg Val Arg Leu Ser Val Leu Gly Pro Ala Gly Glu Gly Pro 
    930                 935                 940                 


Ser Ala Glu Val Thr Ala Arg Thr Glu Ser Pro Arg Val Pro Ser Ile 
945                 950                 955                 960 


Glu Leu Arg Val Val Asp Thr Ser Ile Asp Ser Val Thr Leu Ala Trp 
                965                 970                 975     


Thr Pro Val Ser Arg Ala Ser Ser Tyr Ile Leu Ser Trp Arg Pro Leu 
            980                 985                 990         


Arg Gly Pro Gly Gln Glu Val Pro  Gly Ser Pro Gln Thr  Leu Pro Gly 
        995                 1000                 1005             


Ile Ser  Ser Ser Gln Arg Val  Thr Gly Leu Glu Pro  Gly Val Ser 
    1010                 1015                 1020             


Tyr Ile  Phe Ser Leu Thr Pro  Val Leu Asp Gly Val  Arg Gly Pro 
    1025                 1030                 1035             


Glu Ala  Ser Val Thr Gln Thr  Pro Val Cys Pro Arg  Gly Leu Ala 
    1040                 1045                 1050             


Asp Val  Val Phe Leu Pro His  Ala Thr Gln Asp Asn  Ala His Arg 
    1055                 1060                 1065             


Ala Glu  Ala Thr Arg Arg Val  Leu Glu Arg Leu Val  Leu Ala Leu 
    1070                 1075                 1080             


Gly Pro  Leu Gly Pro Gln Ala  Val Gln Val Gly Leu  Leu Ser Tyr 
    1085                 1090                 1095             


Ser His  Arg Pro Ser Pro Leu  Phe Pro Leu Asn Gly  Ser His Asp 
    1100                 1105                 1110             


Leu Gly  Ile Ile Leu Gln Arg  Ile Arg Asp Met Pro  Tyr Met Asp 
    1115                 1120                 1125             


Pro Ser  Gly Asn Asn Leu Gly  Thr Ala Val Val Thr  Ala His Arg 
    1130                 1135                 1140             


Tyr Met  Leu Ala Pro Asp Ala  Pro Gly Arg Arg Gln  His Val Pro 
    1145                 1150                 1155             


Gly Val  Met Val Leu Leu Val  Asp Glu Pro Leu Arg  Gly Asp Ile 
    1160                 1165                 1170             


Phe Ser  Pro Ile Arg Glu Ala  Gln Ala Ser Gly Leu  Asn Val Val 
    1175                 1180                 1185             


Met Leu  Gly Met Ala Gly Ala  Asp Pro Glu Gln Leu  Arg Arg Leu 
    1190                 1195                 1200             


Ala Pro  Gly Met Asp Ser Val  Gln Thr Phe Phe Ala  Val Asp Asp 
    1205                 1210                 1215             


Gly Pro  Ser Leu Asp Gln Ala  Val Ser Gly Leu Ala  Thr Ala Leu 
    1220                 1225                 1230             


Cys Gln  Ala Ser Phe Thr Thr  Gln Pro Arg Pro Glu  Pro Cys Pro 
    1235                 1240                 1245             


Val Tyr  Cys Pro Lys Gly Gln  Lys Gly Glu Pro Gly  Glu Met Gly 
    1250                 1255                 1260             


Leu Arg  Gly Gln Val Gly Pro  Pro Gly Asp Pro Gly  Leu Pro Gly 
    1265                 1270                 1275             


Arg Thr  Gly Ala Pro Gly Pro  Gln Gly Pro Pro Gly  Ser Ala Thr 
    1280                 1285                 1290             


Ala Lys  Gly Glu Arg Gly Phe  Pro Gly Ala Asp Gly  Arg Pro Gly 
    1295                 1300                 1305             


Ser Pro  Gly Arg Ala Gly Asn  Pro Gly Thr Pro Gly  Ala Pro Gly 
    1310                 1315                 1320             


Leu Lys  Gly Ser Pro Gly Leu  Pro Gly Pro Arg Gly  Asp Pro Gly 
    1325                 1330                 1335             


Glu Arg  Gly Pro Arg Gly Pro  Lys Gly Glu Pro Gly  Ala Pro Gly 
    1340                 1345                 1350             


Gln Val  Ile Gly Gly Glu Gly  Pro Gly Leu Pro Gly  Arg Lys Gly 
    1355                 1360                 1365             


Asp Pro  Gly Pro Ser Gly Pro  Pro Gly Pro Arg Gly  Pro Leu Gly 
    1370                 1375                 1380             


Asp Pro  Gly Pro Arg Gly Pro  Pro Gly Leu Pro Gly  Thr Ala Met 
    1385                 1390                 1395             


Lys Gly  Asp Lys Gly Asp Arg  Gly Glu Arg Gly Pro  Pro Gly Pro 
    1400                 1405                 1410             


Gly Glu  Gly Gly Ile Ala Pro  Gly Glu Pro Gly Leu  Pro Gly Leu 
    1415                 1420                 1425             


Pro Gly  Ser Pro Gly Pro Gln  Gly Pro Val Gly Pro  Pro Gly Lys 
    1430                 1435                 1440             


Lys Gly  Glu Lys Gly Asp Ser  Glu Asp Gly Ala Pro  Gly Leu Pro 
    1445                 1450                 1455             


Gly Gln  Pro Gly Ser Pro Gly  Glu Gln Gly Pro Arg  Gly Pro Pro 
    1460                 1465                 1470             


Gly Ala  Ile Gly Pro Lys Gly  Asp Arg Gly Phe Pro  Gly Pro Leu 
    1475                 1480                 1485             


Gly Glu  Ala Gly Glu Lys Gly  Glu Arg Gly Pro Pro  Gly Pro Ala 
    1490                 1495                 1500             


Gly Ser  Arg Gly Leu Pro Gly  Val Ala Gly Arg Pro  Gly Ala Lys 
    1505                 1510                 1515             


Gly Pro  Glu Gly Pro Pro Gly  Pro Thr Gly Arg Gln  Gly Glu Lys 
    1520                 1525                 1530             


Gly Glu  Pro Gly Arg Pro Gly  Asp Pro Ala Val Val  Gly Pro Ala 
    1535                 1540                 1545             


Val Ala  Gly Pro Lys Gly Glu  Lys Gly Asp Val Gly  Pro Ala Gly 
    1550                 1555                 1560             


Pro Arg  Gly Ala Thr Gly Val  Gln Gly Glu Arg Gly  Pro Pro Gly 
    1565                 1570                 1575             


Leu Val  Leu Pro Gly Asp Pro  Gly Pro Lys Gly Asp  Pro Gly Asp 
    1580                 1585                 1590             


Arg Gly  Pro Ile Gly Leu Thr  Gly Arg Ala Gly Pro  Pro Gly Asp 
    1595                 1600                 1605             


Ser Gly  Pro Pro Gly Glu Lys  Gly Asp Pro Gly Arg  Pro Gly Pro 
    1610                 1615                 1620             


Pro Gly  Pro Val Gly Pro Arg  Gly Arg Asp Gly Glu  Val Gly Glu 
    1625                 1630                 1635             


Lys Gly  Asp Glu Gly Pro Pro  Gly Asp Pro Gly Leu  Pro Gly Lys 
    1640                 1645                 1650             


Ala Gly  Glu Arg Gly Leu Arg  Gly Ala Pro Gly Val  Arg Gly Pro 
    1655                 1660                 1665             


Val Gly  Glu Lys Gly Asp Gln  Gly Asp Pro Gly Glu  Asp Gly Arg 
    1670                 1675                 1680             


Asn Gly  Ser Pro Gly Ser Ser  Gly Pro Lys Gly Asp  Arg Gly Glu 
    1685                 1690                 1695             


Pro Gly  Pro Pro Gly Pro Pro  Gly Arg Leu Val Asp  Thr Gly Pro 
    1700                 1705                 1710             


Gly Ala  Arg Glu Lys Gly Glu  Pro Gly Asp Arg Gly  Gln Glu Gly 
    1715                 1720                 1725             


Pro Arg  Gly Pro Lys Gly Asp  Pro Gly Leu Pro Gly  Ala Pro Gly 
    1730                 1735                 1740             


Glu Arg  Gly Ile Glu Gly Phe  Arg Gly Pro Pro Gly  Pro Gln Gly 
    1745                 1750                 1755             


Asp Pro  Gly Val Arg Gly Pro  Ala Gly Glu Lys Gly  Asp Arg Gly 
    1760                 1765                 1770             


Pro Pro  Gly Leu Asp Gly Arg  Ser Gly Leu Asp Gly  Lys Pro Gly 
    1775                 1780                 1785             


Ala Ala  Gly Pro Ser Gly Pro  Asn Gly Ala Ala Gly  Lys Ala Gly 
    1790                 1795                 1800             


Asp Pro  Gly Arg Asp Gly Leu  Pro Gly Leu Arg Gly  Glu Gln Gly 
    1805                 1810                 1815             


Leu Pro  Gly Pro Ser Gly Pro  Pro Gly Leu Pro Gly  Lys Pro Gly 
    1820                 1825                 1830             


Glu Asp  Gly Lys Pro Gly Leu  Asn Gly Lys Asn Gly  Glu Pro Gly 
    1835                 1840                 1845             


Asp Pro  Gly Glu Asp Gly Arg  Lys Gly Glu Lys Gly  Asp Ser Gly 
    1850                 1855                 1860             


Ala Ser  Gly Arg Glu Gly Arg  Asp Gly Pro Lys Gly  Glu Arg Gly 
    1865                 1870                 1875             


Ala Pro  Gly Ile Leu Gly Pro  Gln Gly Pro Pro Gly  Leu Pro Gly 
    1880                 1885                 1890             


Pro Val  Gly Pro Pro Gly Gln  Gly Phe Pro Gly Val  Pro Gly Gly 
    1895                 1900                 1905             


Thr Gly  Pro Lys Gly Asp Arg  Gly Glu Thr Gly Ser  Lys Gly Glu 
    1910                 1915                 1920             


Gln Gly  Leu Pro Gly Glu Arg  Gly Leu Arg Gly Glu  Pro Gly Ser 
    1925                 1930                 1935             


Val Pro  Asn Val Asp Arg Leu  Leu Glu Thr Ala Gly  Ile Lys Ala 
    1940                 1945                 1950             


Ser Ala  Leu Arg Glu Ile Val  Glu Thr Trp Asp Glu  Ser Ser Gly 
    1955                 1960                 1965             


Ser Phe  Leu Pro Val Pro Glu  Arg Arg Arg Gly Pro  Lys Gly Asp 
    1970                 1975                 1980             


Ser Gly  Glu Gln Gly Pro Pro  Gly Lys Glu Gly Pro  Ile Gly Phe 
    1985                 1990                 1995             


Pro Gly  Glu Arg Gly Leu Lys  Gly Asp Arg Gly Asp  Pro Gly Pro 
    2000                 2005                 2010             


Gln Gly  Pro Pro Gly Leu Ala  Leu Gly Glu Arg Gly  Pro Pro Gly 
    2015                 2020                 2025             


Pro Ser  Gly Leu Ala Gly Glu  Pro Gly Lys Pro Gly  Ile Pro Gly 
    2030                 2035                 2040             


Leu Pro  Gly Arg Ala Gly Gly  Val Gly Glu Ala Gly  Arg Pro Gly 
    2045                 2050                 2055             


Glu Arg  Gly Glu Arg Gly Glu  Lys Gly Glu Arg Gly  Glu Gln Gly 
    2060                 2065                 2070             


Arg Asp  Gly Pro Pro Gly Leu  Pro Gly Thr Pro Gly  Pro Pro Gly 
    2075                 2080                 2085             


Pro Pro  Gly Pro Lys Val Ser  Val Asp Glu Pro Gly  Pro Gly Leu 
    2090                 2095                 2100             


Ser Gly  Glu Gln Gly Pro Pro  Gly Leu Lys Gly Ala  Lys Gly Glu 
    2105                 2110                 2115             


Pro Gly  Ser Asn Gly Asp Gln  Gly Pro Lys Gly Asp  Arg Gly Val 
    2120                 2125                 2130             


Pro Gly  Ile Lys Gly Asp Arg  Gly Glu Pro Gly Pro  Arg Gly Gln 
    2135                 2140                 2145             


Asp Gly  Asn Pro Gly Leu Pro  Gly Glu Arg Gly Met  Ala Gly Pro 
    2150                 2155                 2160             


Glu Gly  Lys Pro Gly Leu Gln  Gly Pro Arg Gly Pro  Pro Gly Pro 
    2165                 2170                 2175             


Val Gly  Gly His Gly Asp Pro  Gly Pro Pro Gly Ala  Pro Gly Leu 
    2180                 2185                 2190             


Ala Gly  Pro Ala Gly Pro Gln  Gly Pro Ser Gly Leu  Lys Gly Glu 
    2195                 2200                 2205             


Pro Gly  Glu Thr Gly Pro Pro  Gly Arg Gly Leu Thr  Gly Pro Thr 
    2210                 2215                 2220             


Gly Ala  Val Gly Leu Pro Gly  Pro Pro Gly Pro Ser  Gly Leu Val 
    2225                 2230                 2235             


Gly Pro  Gln Gly Ser Pro Gly  Leu Pro Gly Gln Val  Gly Glu Thr 
    2240                 2245                 2250             


Gly Lys  Pro Gly Ala Pro Gly  Arg Asp Gly Ala Ser  Gly Lys Asp 
    2255                 2260                 2265             


Gly Asp  Arg Gly Ser Pro Gly  Val Pro Gly Ser Pro  Gly Leu Pro 
    2270                 2275                 2280             


Gly Pro  Val Gly Pro Lys Gly  Glu Pro Gly Pro Thr  Gly Ala Pro 
    2285                 2290                 2295             


Gly Gln  Ala Val Val Gly Leu  Pro Gly Ala Lys Gly  Glu Lys Gly 
    2300                 2305                 2310             


Ala Pro  Gly Gly Leu Ala Gly  Asp Leu Val Gly Glu  Pro Gly Ala 
    2315                 2320                 2325             


Lys Gly  Asp Arg Gly Leu Pro  Gly Pro Arg Gly Glu  Lys Gly Glu 
    2330                 2335                 2340             


Ala Gly  Arg Ala Gly Glu Pro  Gly Asp Pro Gly Glu  Asp Gly Gln 
    2345                 2350                 2355             


Lys Gly  Ala Pro Gly Pro Lys  Gly Phe Lys Gly Asp  Pro Gly Val 
    2360                 2365                 2370             


Gly Val  Pro Gly Ser Pro Gly  Pro Pro Gly Pro Pro  Gly Val Lys 
    2375                 2380                 2385             


Gly Asp  Leu Gly Leu Pro Gly  Leu Pro Gly Ala Pro  Gly Val Val 
    2390                 2395                 2400             


Gly Phe  Pro Gly Gln Thr Gly  Pro Arg Gly Glu Met  Gly Gln Pro 
    2405                 2410                 2415             


Gly Pro  Ser Gly Glu Arg Gly  Leu Ala Gly Pro Pro  Gly Arg Glu 
    2420                 2425                 2430             


Gly Ile  Pro Gly Pro Leu Gly  Pro Pro Gly Pro Pro  Gly Ser Val 
    2435                 2440                 2445             


Gly Pro  Pro Gly Ala Ser Gly  Leu Lys Gly Asp Lys  Gly Asp Pro 
    2450                 2455                 2460             


Gly Val  Gly Leu Pro Gly Pro  Arg Gly Glu Arg Gly  Glu Pro Gly 
    2465                 2470                 2475             


Ile Arg  Gly Glu Asp Gly Arg  Pro Gly Gln Glu Gly  Pro Arg Gly 
    2480                 2485                 2490             


Leu Thr  Gly Pro Pro Gly Ser  Arg Gly Glu Arg Gly  Glu Lys Gly 
    2495                 2500                 2505             


Asp Val  Gly Ser Ala Gly Leu  Lys Gly Asp Lys Gly  Asp Ser Ala 
    2510                 2515                 2520             


Val Ile  Leu Gly Pro Pro Gly  Pro Arg Gly Ala Lys  Gly Asp Met 
    2525                 2530                 2535             


Gly Glu  Arg Gly Pro Arg Gly  Leu Asp Gly Asp Lys  Gly Pro Arg 
    2540                 2545                 2550             


Gly Asp  Asn Gly Asp Pro Gly  Asp Lys Gly Ser Lys  Gly Glu Pro 
    2555                 2560                 2565             


Gly Asp  Lys Gly Ser Ala Gly  Leu Pro Gly Leu Arg  Gly Leu Leu 
    2570                 2575                 2580             


Gly Pro  Gln Gly Gln Pro Gly  Ala Ala Gly Ile Pro  Gly Asp Pro 
    2585                 2590                 2595             


Gly Ser  Pro Gly Lys Asp Gly  Val Pro Gly Ile Arg  Gly Glu Lys 
    2600                 2605                 2610             


Gly Asp  Val Gly Phe Met Gly  Pro Arg Gly Leu Lys  Gly Glu Arg 
    2615                 2620                 2625             


Gly Val  Lys Gly Ala Cys Gly  Leu Asp Gly Glu Lys  Gly Asp Lys 
    2630                 2635                 2640             


Gly Glu  Ala Gly Pro Pro Gly  Arg Pro Gly Leu Ala  Gly His Lys 
    2645                 2650                 2655             


Gly Glu  Met Gly Glu Pro Gly  Val Pro Gly Gln Ser  Gly Ala Pro 
    2660                 2665                 2670             


Gly Lys  Glu Gly Leu Ile Gly  Pro Lys Gly Asp Arg  Gly Phe Asp 
    2675                 2680                 2685             


Gly Gln  Pro Gly Pro Lys Gly  Asp Gln Gly Glu Lys  Gly Glu Arg 
    2690                 2695                 2700             


Gly Thr  Pro Gly Ile Gly Gly  Phe Pro Gly Pro Ser  Gly Asn Asp 
    2705                 2710                 2715             


Gly Ser  Ala Gly Pro Pro Gly  Pro Pro Gly Ser Val  Gly Pro Arg 
    2720                 2725                 2730             


Gly Pro  Glu Gly Leu Gln Gly  Gln Lys Gly Glu Arg  Gly Pro Pro 
    2735                 2740                 2745             


Gly Glu  Arg Val Val Gly Ala  Pro Gly Val Pro Gly  Ala Pro Gly 
    2750                 2755                 2760             


Glu Arg  Gly Glu Gln Gly Arg  Pro Gly Pro Ala Gly  Pro Arg Gly 
    2765                 2770                 2775             


Glu Lys  Gly Glu Ala Ala Leu  Thr Glu Asp Asp Ile  Arg Gly Phe 
    2780                 2785                 2790             


Val Arg  Gln Glu Met Ser Gln  His Cys Ala Cys Gln  Gly Gln Phe 
    2795                 2800                 2805             


Ile Ala  Ser Gly Ser Arg Pro  Leu Pro Ser Tyr Ala  Ala Asp Thr 
    2810                 2815                 2820             


Ala Gly  Ser Gln Leu His Ala  Val Pro Val Leu Arg  Val Ser His 
    2825                 2830                 2835             


Ala Glu  Glu Glu Glu Arg Val  Pro Pro Glu Asp Asp  Glu Tyr Ser 
    2840                 2845                 2850             


Glu Tyr  Ser Glu Tyr Ser Val  Glu Glu Tyr Gln Asp  Pro Glu Ala 
    2855                 2860                 2865             


Pro Trp  Asp Ser Asp Asp Pro  Cys Ser Leu Pro Leu  Asp Glu Gly 
    2870                 2875                 2880             


Ser Cys  Thr Ala Tyr Thr Leu  Arg Trp Tyr His Arg  Ala Val Thr 
    2885                 2890                 2895             


Gly Ser  Thr Glu Ala Cys His  Pro Phe Val Tyr Gly  Gly Cys Gly 
    2900                 2905                 2910             


Gly Asn  Ala Asn Arg Phe Gly  Thr Arg Glu Ala Cys  Glu Arg Arg 
    2915                 2920                 2925             


Cys Pro  Pro Arg Val Val Gln  Ser Gln Gly Thr Gly  Thr Ala Gln 
    2930                 2935                 2940             


Asp 
    


<210>  3348
<211>  114
<212>  PRT
<213>  Homo Sapiens

<400>  3348

Met Ala Val Leu Pro Gly Pro Leu Gln Leu Leu Gly Val Leu Leu Thr 
1               5                   10                  15      


Ile Ser Leu Ser Ser Ile Arg Leu Ile Gln Ala Gly Ala Tyr Tyr Gly 
            20                  25                  30          


Ile Lys Pro Leu Pro Pro Gln Ile Pro Pro Gln Met Pro Pro Gln Ile 
        35                  40                  45              


Pro Gln Tyr Gln Pro Leu Gly Gln Gln Val Pro His Met Pro Leu Ala 
    50                  55                  60                  


Lys Asp Gly Leu Ala Met Gly Lys Glu Met Pro His Leu Gln Tyr Gly 
65                  70                  75                  80  


Lys Glu Tyr Pro His Leu Pro Gln Tyr Met Lys Glu Ile Gln Pro Ala 
                85                  90                  95      


Pro Arg Met Gly Lys Glu Ala Val Pro Lys Lys Gly Lys Glu Ile Pro 
            100                 105                 110         


Leu Ala 
        


<210>  3349
<211>  202
<212>  PRT
<213>  Homo Sapiens

<400>  3349

Met Ala Val Leu Pro Gly Pro Leu Gln Leu Leu Gly Val Leu Leu Thr 
1               5                   10                  15      


Ile Ser Leu Ser Ser Ile Arg Leu Ile Gln Ala Gly Ala Tyr Tyr Gly 
            20                  25                  30          


Ile Lys Pro Leu Pro Pro Gln Ile Pro Pro Gln Met Pro Pro Gln Ile 
        35                  40                  45              


Pro Gln Tyr Gln Pro Leu Gly Gln Gln Val Pro His Met Pro Leu Ala 
    50                  55                  60                  


Lys Asp Gly Leu Ala Met Gly Lys Glu Met Pro His Leu Gln Tyr Gly 
65                  70                  75                  80  


Lys Glu Tyr Pro His Leu Pro Gln Tyr Met Lys Glu Ile Gln Pro Ala 
                85                  90                  95      


Pro Arg Met Gly Lys Glu Ala Val Pro Lys Lys Gly Lys Glu Ile Pro 
            100                 105                 110         


Leu Ala Ser Leu Arg Gly Glu Gln Gly Pro Arg Gly Glu Pro Gly Pro 
        115                 120                 125             


Arg Gly Pro Pro Gly Pro Pro Gly Leu Pro Gly His Gly Ile Pro Gly 
    130                 135                 140                 


Ile Lys Gly Lys Pro Gly Pro Gln Gly Tyr Pro Gly Val Gly Lys Pro 
145                 150                 155                 160 


Gly Met Pro Gly Met Pro Gly Lys Pro Gly Ala Met Gly Met Pro Gly 
                165                 170                 175     


Ala Lys Gly Glu Ile Gly Gln Lys Gly Glu Ile Gly Pro Met Gly Ile 
            180                 185                 190         


Pro Gly Pro Gln Gly Pro Pro Gly Pro His 
        195                 200         


<210>  3350
<211>  744
<212>  PRT
<213>  Homo Sapiens

<400>  3350

Met Ala Val Leu Pro Gly Pro Leu Gln Leu Leu Gly Val Leu Leu Thr 
1               5                   10                  15      


Ile Ser Leu Ser Ser Ile Arg Leu Ile Gln Ala Gly Ala Tyr Tyr Gly 
            20                  25                  30          


Ile Lys Pro Leu Pro Pro Gln Ile Pro Pro Gln Met Pro Pro Gln Ile 
        35                  40                  45              


Pro Gln Tyr Gln Pro Leu Gly Gln Gln Val Pro His Met Pro Leu Ala 
    50                  55                  60                  


Lys Asp Gly Leu Ala Met Gly Lys Glu Met Pro His Leu Gln Tyr Gly 
65                  70                  75                  80  


Lys Glu Tyr Pro His Leu Pro Gln Tyr Met Lys Glu Ile Gln Pro Ala 
                85                  90                  95      


Pro Arg Met Gly Lys Glu Ala Val Pro Lys Lys Gly Lys Glu Ile Pro 
            100                 105                 110         


Leu Ala Ser Leu Arg Gly Glu Gln Gly Pro Arg Gly Glu Pro Gly Pro 
        115                 120                 125             


Arg Gly Pro Pro Gly Pro Pro Gly Leu Pro Gly His Gly Ile Pro Gly 
    130                 135                 140                 


Ile Lys Gly Lys Pro Gly Pro Gln Gly Tyr Pro Gly Val Gly Lys Pro 
145                 150                 155                 160 


Gly Met Pro Gly Met Pro Gly Lys Pro Gly Ala Met Gly Met Pro Gly 
                165                 170                 175     


Ala Lys Gly Glu Ile Gly Gln Lys Gly Glu Ile Gly Pro Met Gly Ile 
            180                 185                 190         


Pro Gly Pro Gln Gly Pro Pro Gly Pro His Gly Leu Pro Gly Ile Gly 
        195                 200                 205             


Lys Pro Gly Gly Pro Gly Leu Pro Gly Gln Pro Gly Pro Lys Gly Asp 
    210                 215                 220                 


Arg Gly Pro Lys Gly Leu Pro Gly Pro Gln Gly Leu Arg Gly Pro Lys 
225                 230                 235                 240 


Gly Asp Lys Gly Phe Gly Met Pro Gly Ala Pro Gly Val Lys Gly Pro 
                245                 250                 255     


Pro Gly Met His Gly Pro Pro Gly Pro Val Gly Leu Pro Gly Val Gly 
            260                 265                 270         


Lys Pro Gly Val Thr Gly Phe Pro Gly Pro Gln Gly Pro Leu Gly Lys 
        275                 280                 285             


Pro Gly Ala Pro Gly Glu Pro Gly Pro Gln Gly Pro Ile Gly Val Pro 
    290                 295                 300                 


Gly Val Gln Gly Pro Pro Gly Ile Pro Gly Ile Gly Lys Pro Gly Gln 
305                 310                 315                 320 


Asp Gly Ile Pro Gly Gln Pro Gly Phe Pro Gly Gly Lys Gly Glu Gln 
                325                 330                 335     


Gly Leu Pro Gly Leu Pro Gly Pro Pro Gly Leu Pro Gly Ile Gly Lys 
            340                 345                 350         


Pro Gly Phe Pro Gly Pro Lys Gly Asp Arg Gly Met Gly Gly Val Pro 
        355                 360                 365             


Gly Ala Leu Gly Pro Arg Gly Glu Lys Gly Pro Ile Gly Ala Pro Gly 
    370                 375                 380                 


Ile Gly Gly Pro Pro Gly Glu Pro Gly Leu Pro Gly Ile Pro Gly Pro 
385                 390                 395                 400 


Met Gly Pro Pro Gly Ala Ile Gly Phe Pro Gly Pro Lys Gly Glu Gly 
                405                 410                 415     


Gly Ile Val Gly Pro Gln Gly Pro Pro Gly Pro Lys Gly Glu Pro Gly 
            420                 425                 430         


Leu Gln Gly Phe Pro Gly Lys Pro Gly Phe Leu Gly Glu Val Gly Pro 
        435                 440                 445             


Pro Gly Met Arg Gly Leu Pro Gly Pro Ile Gly Pro Lys Gly Glu Ala 
    450                 455                 460                 


Gly Gln Lys Gly Val Pro Gly Leu Pro Gly Val Pro Gly Leu Leu Gly 
465                 470                 475                 480 


Pro Lys Gly Glu Pro Gly Ile Pro Gly Asp Gln Gly Leu Gln Gly Pro 
                485                 490                 495     


Pro Gly Ile Pro Gly Ile Gly Gly Pro Ser Gly Pro Ile Gly Pro Pro 
            500                 505                 510         


Gly Ile Pro Gly Pro Lys Gly Glu Pro Gly Leu Pro Gly Pro Pro Gly 
        515                 520                 525             


Phe Pro Gly Ile Gly Lys Pro Gly Val Ala Gly Leu His Gly Pro Pro 
    530                 535                 540                 


Gly Lys Pro Gly Ala Leu Gly Pro Gln Gly Gln Pro Gly Leu Pro Gly 
545                 550                 555                 560 


Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Ala Val Met Pro Pro 
                565                 570                 575     


Thr Pro Pro Pro Gln Gly Glu Tyr Leu Pro Asp Met Gly Leu Gly Ile 
            580                 585                 590         


Asp Gly Val Lys Pro Pro His Ala Tyr Gly Ala Lys Lys Gly Lys Asn 
        595                 600                 605             


Gly Gly Pro Ala Tyr Glu Met Pro Ala Phe Thr Ala Glu Leu Thr Ala 
    610                 615                 620                 


Pro Phe Pro Pro Val Gly Ala Pro Val Lys Phe Asn Lys Leu Leu Tyr 
625                 630                 635                 640 


Asn Gly Arg Gln Asn Tyr Asn Pro Gln Thr Gly Ile Phe Thr Cys Glu 
                645                 650                 655     


Val Pro Gly Val Tyr Tyr Phe Ala Tyr His Val His Cys Lys Gly Gly 
            660                 665                 670         


Asn Val Trp Val Ala Leu Phe Lys Asn Asn Glu Pro Val Met Tyr Thr 
        675                 680                 685             


Tyr Asp Glu Tyr Lys Lys Gly Phe Leu Asp Gln Ala Ser Gly Ser Ala 
    690                 695                 700                 


Val Leu Leu Leu Arg Pro Gly Asp Arg Val Phe Leu Gln Met Pro Ser 
705                 710                 715                 720 


Glu Gln Ala Ala Gly Leu Tyr Ala Gly Gln Tyr Val His Ser Ser Phe 
                725                 730                 735     


Ser Gly Tyr Leu Leu Tyr Pro Met 
            740                 


<210>  3351
<211>  744
<212>  PRT
<213>  Homo Sapiens

<400>  3351

Met Ala Val Leu Pro Gly Pro Leu Gln Leu Leu Gly Val Leu Leu Thr 
1               5                   10                  15      


Ile Ser Leu Ser Ser Ile Arg Leu Ile Gln Ala Gly Ala Tyr Tyr Gly 
            20                  25                  30          


Ile Lys Pro Leu Pro Pro Gln Ile Pro Pro Gln Met Pro Pro Gln Ile 
        35                  40                  45              


Pro Gln Tyr Gln Pro Leu Gly Gln Gln Val Pro His Met Pro Leu Ala 
    50                  55                  60                  


Lys Asp Gly Leu Ala Met Gly Lys Glu Met Pro His Leu Gln Tyr Gly 
65                  70                  75                  80  


Lys Glu Tyr Pro His Leu Pro Gln Tyr Met Lys Glu Ile Gln Pro Ala 
                85                  90                  95      


Pro Arg Met Gly Lys Glu Ala Val Pro Lys Lys Gly Lys Glu Ile Pro 
            100                 105                 110         


Leu Ala Ser Leu Arg Gly Glu Gln Gly Pro Arg Gly Glu Pro Gly Pro 
        115                 120                 125             


Arg Gly Pro Pro Gly Pro Pro Gly Leu Pro Gly His Gly Ile Pro Gly 
    130                 135                 140                 


Ile Lys Gly Lys Pro Gly Pro Gln Gly Tyr Pro Gly Val Gly Lys Pro 
145                 150                 155                 160 


Gly Met Pro Gly Met Pro Gly Lys Pro Gly Ala Met Gly Met Pro Gly 
                165                 170                 175     


Ala Lys Gly Glu Ile Gly Gln Lys Gly Glu Ile Gly Pro Met Gly Ile 
            180                 185                 190         


Pro Gly Pro Gln Gly Pro Pro Gly Pro His Gly Leu Pro Gly Ile Gly 
        195                 200                 205             


Lys Pro Gly Gly Pro Gly Leu Pro Gly Gln Pro Gly Pro Lys Gly Asp 
    210                 215                 220                 


Arg Gly Pro Lys Gly Leu Pro Gly Pro Gln Gly Leu Arg Gly Pro Lys 
225                 230                 235                 240 


Gly Asp Lys Gly Phe Gly Met Pro Gly Ala Pro Gly Val Lys Gly Pro 
                245                 250                 255     


Pro Gly Met His Gly Pro Pro Gly Pro Val Gly Leu Pro Gly Val Gly 
            260                 265                 270         


Lys Pro Gly Val Thr Gly Phe Pro Gly Pro Gln Gly Pro Leu Gly Lys 
        275                 280                 285             


Pro Gly Ala Pro Gly Glu Pro Gly Pro Gln Gly Pro Ile Gly Val Pro 
    290                 295                 300                 


Gly Val Gln Gly Pro Pro Gly Ile Pro Gly Ile Gly Lys Pro Gly Gln 
305                 310                 315                 320 


Asp Gly Ile Pro Gly Gln Pro Gly Phe Pro Gly Gly Lys Gly Glu Gln 
                325                 330                 335     


Gly Leu Pro Gly Leu Pro Gly Pro Pro Gly Leu Pro Gly Ile Gly Lys 
            340                 345                 350         


Pro Gly Phe Pro Gly Pro Lys Gly Asp Arg Gly Met Gly Gly Val Pro 
        355                 360                 365             


Gly Ala Leu Gly Pro Arg Gly Glu Lys Gly Pro Ile Gly Ala Pro Gly 
    370                 375                 380                 


Ile Gly Gly Pro Pro Gly Glu Pro Gly Leu Pro Gly Ile Pro Gly Pro 
385                 390                 395                 400 


Met Gly Pro Pro Gly Ala Ile Gly Phe Pro Gly Pro Lys Gly Glu Gly 
                405                 410                 415     


Gly Ile Val Gly Pro Gln Gly Pro Pro Gly Pro Lys Gly Glu Pro Gly 
            420                 425                 430         


Leu Gln Gly Phe Pro Gly Lys Pro Gly Phe Leu Gly Glu Val Gly Pro 
        435                 440                 445             


Pro Gly Met Arg Gly Leu Pro Gly Pro Ile Gly Pro Lys Gly Glu Ala 
    450                 455                 460                 


Gly Gln Lys Gly Val Pro Gly Leu Pro Gly Val Pro Gly Leu Leu Gly 
465                 470                 475                 480 


Pro Lys Gly Glu Pro Gly Ile Pro Gly Asp Gln Gly Leu Gln Gly Pro 
                485                 490                 495     


Pro Gly Ile Pro Gly Ile Gly Gly Pro Ser Gly Pro Ile Gly Pro Pro 
            500                 505                 510         


Gly Ile Pro Gly Pro Lys Gly Glu Pro Gly Leu Pro Gly Pro Pro Gly 
        515                 520                 525             


Phe Pro Gly Ile Gly Lys Pro Gly Val Ala Gly Leu His Gly Pro Pro 
    530                 535                 540                 


Gly Lys Pro Gly Ala Leu Gly Pro Gln Gly Gln Pro Gly Leu Pro Gly 
545                 550                 555                 560 


Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Ala Val Met Pro Pro 
                565                 570                 575     


Thr Pro Pro Pro Gln Gly Glu Tyr Leu Pro Asp Met Gly Leu Gly Ile 
            580                 585                 590         


Asp Gly Val Lys Pro Pro His Ala Tyr Gly Ala Lys Lys Gly Lys Asn 
        595                 600                 605             


Gly Gly Pro Ala Tyr Glu Met Pro Ala Phe Thr Ala Glu Leu Thr Ala 
    610                 615                 620                 


Pro Phe Pro Pro Val Gly Ala Pro Val Lys Phe Asn Lys Leu Leu Tyr 
625                 630                 635                 640 


Asn Gly Arg Gln Asn Tyr Asn Pro Gln Thr Gly Ile Phe Thr Cys Glu 
                645                 650                 655     


Val Pro Gly Val Tyr Tyr Phe Ala Tyr His Val His Cys Lys Gly Gly 
            660                 665                 670         


Asn Val Trp Val Ala Leu Phe Lys Asn Asn Glu Pro Val Met Tyr Thr 
        675                 680                 685             


Tyr Asp Glu Tyr Lys Lys Gly Phe Leu Asp Gln Ala Ser Gly Ser Ala 
    690                 695                 700                 


Val Leu Leu Leu Arg Pro Gly Asp Arg Val Phe Leu Gln Met Pro Ser 
705                 710                 715                 720 


Glu Gln Ala Ala Gly Leu Tyr Ala Gly Gln Tyr Val His Ser Ser Phe 
                725                 730                 735     


Ser Gly Tyr Leu Leu Tyr Pro Met 
            740                 


<210>  3352
<211>  703
<212>  PRT
<213>  Homo Sapiens

<400>  3352

Met Leu Gly Thr Leu Thr Pro Leu Ser Ser Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Val Leu Val Leu Gly Cys Gly Pro Arg Ala Ser Ser Gly Gly Gly Ala 
            20                  25                  30          


Gly Gly Ala Ala Gly Tyr Ala Pro Val Lys Tyr Ile Gln Pro Met Gln 
        35                  40                  45              


Lys Gly Pro Val Gly Pro Pro Phe Arg Glu Gly Lys Gly Gln Tyr Leu 
    50                  55                  60                  


Glu Met Pro Leu Pro Leu Leu Pro Met Asp Leu Lys Gly Glu Pro Gly 
65                  70                  75                  80  


Pro Pro Gly Lys Pro Gly Pro Arg Gly Pro Pro Gly Pro Pro Gly Phe 
                85                  90                  95      


Pro Gly Lys Pro Gly Met Gly Lys Pro Gly Leu His Gly Gln Pro Gly 
            100                 105                 110         


Pro Ala Gly Pro Pro Gly Phe Ser Arg Met Gly Lys Ala Gly Pro Pro 
        115                 120                 125             


Gly Leu Pro Gly Lys Val Gly Pro Pro Gly Gln Pro Gly Leu Arg Gly 
    130                 135                 140                 


Glu Pro Gly Ile Arg Gly Asp Gln Gly Leu Arg Gly Pro Pro Gly Pro 
145                 150                 155                 160 


Pro Gly Leu Pro Gly Pro Ser Gly Ile Thr Ile Pro Gly Lys Pro Gly 
                165                 170                 175     


Ala Gln Gly Val Pro Gly Pro Pro Gly Phe Gln Gly Glu Pro Gly Pro 
            180                 185                 190         


Gln Gly Glu Pro Gly Pro Pro Gly Asp Arg Gly Leu Lys Gly Asp Asn 
        195                 200                 205             


Gly Val Gly Gln Pro Gly Leu Pro Gly Ala Pro Gly Gln Gly Gly Ala 
    210                 215                 220                 


Pro Gly Pro Pro Gly Leu Pro Gly Pro Ala Gly Leu Gly Lys Pro Gly 
225                 230                 235                 240 


Leu Asp Gly Leu Pro Gly Ala Pro Gly Asp Lys Gly Glu Ser Gly Pro 
                245                 250                 255     


Pro Gly Val Pro Gly Pro Arg Gly Glu Pro Gly Ala Val Gly Pro Lys 
            260                 265                 270         


Gly Pro Pro Gly Val Asp Gly Val Gly Val Pro Gly Ala Ala Gly Leu 
        275                 280                 285             


Pro Gly Pro Gln Gly Pro Ser Gly Ala Lys Gly Glu Pro Gly Thr Arg 
    290                 295                 300                 


Gly Pro Pro Gly Leu Ile Gly Pro Thr Gly Tyr Gly Met Pro Gly Leu 
305                 310                 315                 320 


Pro Gly Pro Lys Gly Asp Arg Gly Pro Ala Gly Val Pro Gly Leu Leu 
                325                 330                 335     


Gly Asp Arg Gly Glu Pro Gly Glu Asp Gly Glu Pro Gly Glu Gln Gly 
            340                 345                 350         


Pro Gln Gly Leu Gly Gly Pro Pro Gly Leu Pro Gly Ser Ala Gly Leu 
        355                 360                 365             


Pro Gly Arg Arg Gly Pro Pro Gly Pro Lys Gly Glu Ala Gly Pro Gly 
    370                 375                 380                 


Gly Pro Pro Gly Val Pro Gly Ile Arg Gly Asp Gln Gly Pro Ser Gly 
385                 390                 395                 400 


Leu Ala Gly Lys Pro Gly Val Pro Gly Glu Arg Gly Leu Pro Gly Ala 
                405                 410                 415     


His Gly Pro Pro Gly Pro Thr Gly Pro Lys Gly Glu Pro Gly Phe Thr 
            420                 425                 430         


Gly Arg Pro Gly Gly Pro Gly Val Ala Gly Ala Leu Gly Gln Lys Gly 
        435                 440                 445             


Asp Leu Gly Leu Pro Gly Gln Pro Gly Leu Arg Gly Pro Ser Gly Ile 
    450                 455                 460                 


Pro Gly Leu Gln Gly Pro Ala Gly Pro Ile Gly Pro Gln Gly Leu Pro 
465                 470                 475                 480 


Gly Leu Lys Gly Glu Pro Gly Leu Pro Gly Pro Pro Gly Glu Gly Arg 
                485                 490                 495     


Ala Gly Glu Pro Gly Thr Ala Gly Pro Thr Gly Pro Pro Gly Val Pro 
            500                 505                 510         


Gly Ser Pro Gly Ile Thr Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
        515                 520                 525             


Pro Pro Gly Ala Pro Gly Ala Phe Asp Glu Thr Gly Ile Ala Gly Leu 
    530                 535                 540                 


His Leu Pro Asn Gly Gly Val Glu Gly Ala Val Leu Gly Lys Gly Gly 
545                 550                 555                 560 


Lys Pro Gln Phe Gly Leu Gly Glu Leu Ser Ala His Ala Thr Pro Ala 
                565                 570                 575     


Phe Thr Ala Val Leu Thr Ser Pro Phe Pro Ala Ser Gly Met Pro Val 
            580                 585                 590         


Lys Phe Asp Arg Thr Leu Tyr Asn Gly His Ser Gly Tyr Asn Pro Ala 
        595                 600                 605             


Thr Gly Ile Phe Thr Cys Pro Val Gly Gly Val Tyr Tyr Phe Ala Tyr 
    610                 615                 620                 


His Val His Val Lys Gly Thr Asn Val Trp Val Ala Leu Tyr Lys Asn 
625                 630                 635                 640 


Asn Val Pro Ala Thr Tyr Thr Tyr Asp Glu Tyr Lys Lys Gly Tyr Leu 
                645                 650                 655     


Asp Gln Ala Ser Gly Gly Ala Val Leu Gln Leu Arg Pro Asn Asp Gln 
            660                 665                 670         


Val Trp Val Gln Met Pro Ser Asp Gln Ala Asn Gly Leu Tyr Ser Thr 
        675                 680                 685             


Glu Tyr Ile His Ser Ser Phe Ser Gly Phe Leu Leu Cys Pro Thr 
    690                 695                 700             


<210>  3353
<211>  703
<212>  PRT
<213>  Homo Sapiens

<400>  3353

Met Leu Gly Thr Leu Thr Pro Leu Ser Ser Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Val Leu Val Leu Gly Cys Gly Pro Arg Ala Ser Ser Gly Gly Gly Ala 
            20                  25                  30          


Gly Gly Ala Ala Gly Tyr Ala Pro Val Lys Tyr Ile Gln Pro Met Gln 
        35                  40                  45              


Lys Gly Pro Val Gly Pro Pro Phe Arg Glu Gly Lys Gly Gln Tyr Leu 
    50                  55                  60                  


Glu Met Pro Leu Pro Leu Leu Pro Met Asp Leu Lys Gly Glu Pro Gly 
65                  70                  75                  80  


Pro Pro Gly Lys Pro Gly Pro Arg Gly Pro Pro Gly Pro Pro Gly Phe 
                85                  90                  95      


Pro Gly Lys Pro Gly Met Gly Lys Pro Gly Leu His Gly Gln Pro Gly 
            100                 105                 110         


Pro Ala Gly Pro Pro Gly Phe Ser Arg Met Gly Lys Ala Gly Pro Pro 
        115                 120                 125             


Gly Leu Pro Gly Lys Val Gly Pro Pro Gly Gln Pro Gly Leu Arg Gly 
    130                 135                 140                 


Glu Pro Gly Ile Arg Gly Asp Gln Gly Leu Arg Gly Pro Pro Gly Pro 
145                 150                 155                 160 


Pro Gly Leu Pro Gly Pro Ser Gly Ile Thr Ile Pro Gly Lys Pro Gly 
                165                 170                 175     


Ala Gln Gly Val Pro Gly Pro Pro Gly Phe Gln Gly Glu Pro Gly Pro 
            180                 185                 190         


Gln Gly Glu Pro Gly Pro Pro Gly Asp Arg Gly Leu Lys Gly Asp Asn 
        195                 200                 205             


Gly Val Gly Gln Pro Gly Leu Pro Gly Ala Pro Gly Gln Gly Gly Ala 
    210                 215                 220                 


Pro Gly Pro Pro Gly Leu Pro Gly Pro Ala Gly Leu Gly Lys Pro Gly 
225                 230                 235                 240 


Leu Asp Gly Leu Pro Gly Ala Pro Gly Asp Lys Gly Glu Ser Gly Pro 
                245                 250                 255     


Pro Gly Val Pro Gly Pro Arg Gly Glu Pro Gly Ala Val Gly Pro Lys 
            260                 265                 270         


Gly Pro Pro Gly Val Asp Gly Val Gly Val Pro Gly Ala Ala Gly Leu 
        275                 280                 285             


Pro Gly Pro Gln Gly Pro Ser Gly Ala Lys Gly Glu Pro Gly Thr Arg 
    290                 295                 300                 


Gly Pro Pro Gly Leu Ile Gly Pro Thr Gly Tyr Gly Met Pro Gly Leu 
305                 310                 315                 320 


Pro Gly Pro Lys Gly Asp Arg Gly Pro Ala Gly Val Pro Gly Leu Leu 
                325                 330                 335     


Gly Asp Arg Gly Glu Pro Gly Glu Asp Gly Glu Pro Gly Glu Gln Gly 
            340                 345                 350         


Pro Gln Gly Leu Gly Gly Pro Pro Gly Leu Pro Gly Ser Ala Gly Leu 
        355                 360                 365             


Pro Gly Arg Arg Gly Pro Pro Gly Pro Lys Gly Glu Ala Gly Pro Gly 
    370                 375                 380                 


Gly Pro Pro Gly Val Pro Gly Ile Arg Gly Asp Gln Gly Pro Ser Gly 
385                 390                 395                 400 


Leu Ala Gly Lys Pro Gly Val Pro Gly Glu Arg Gly Leu Pro Gly Ala 
                405                 410                 415     


His Gly Pro Pro Gly Pro Thr Gly Pro Lys Gly Glu Pro Gly Phe Thr 
            420                 425                 430         


Gly Arg Pro Gly Gly Pro Gly Val Ala Gly Ala Leu Gly Gln Lys Gly 
        435                 440                 445             


Asp Leu Gly Leu Pro Gly Gln Pro Gly Leu Arg Gly Pro Ser Gly Ile 
    450                 455                 460                 


Pro Gly Leu Gln Gly Pro Ala Gly Pro Ile Gly Pro Gln Gly Leu Pro 
465                 470                 475                 480 


Gly Leu Lys Gly Glu Pro Gly Leu Pro Gly Pro Pro Gly Glu Gly Arg 
                485                 490                 495     


Ala Gly Glu Pro Gly Thr Ala Gly Pro Thr Gly Pro Pro Gly Val Pro 
            500                 505                 510         


Gly Ser Pro Gly Ile Thr Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
        515                 520                 525             


Pro Pro Gly Ala Pro Gly Ala Phe Asp Glu Thr Gly Ile Ala Gly Leu 
    530                 535                 540                 


His Leu Pro Asn Gly Gly Val Glu Gly Ala Val Leu Gly Lys Gly Gly 
545                 550                 555                 560 


Lys Pro Gln Phe Gly Leu Gly Glu Leu Ser Ala His Ala Thr Pro Ala 
                565                 570                 575     


Phe Thr Ala Val Leu Thr Ser Pro Phe Pro Ala Ser Gly Met Pro Val 
            580                 585                 590         


Lys Phe Asp Arg Thr Leu Tyr Asn Gly His Ser Gly Tyr Asn Pro Ala 
        595                 600                 605             


Thr Gly Ile Phe Thr Cys Pro Val Gly Gly Val Tyr Tyr Phe Ala Tyr 
    610                 615                 620                 


His Val His Val Lys Gly Thr Asn Val Trp Val Ala Leu Tyr Lys Asn 
625                 630                 635                 640 


Asn Val Pro Ala Thr Tyr Thr Tyr Asp Glu Tyr Lys Lys Gly Tyr Leu 
                645                 650                 655     


Asp Gln Ala Ser Gly Gly Ala Val Leu Gln Leu Arg Pro Asn Asp Gln 
            660                 665                 670         


Val Trp Val Gln Met Pro Ser Asp Gln Ala Asn Gly Leu Tyr Ser Thr 
        675                 680                 685             


Glu Tyr Ile His Ser Ser Phe Ser Gly Phe Leu Leu Cys Pro Thr 
    690                 695                 700             


<210>  3354
<211>  638
<212>  PRT
<213>  Homo Sapiens

<400>  3354

Met Pro Leu Pro Leu Leu Pro Met Asp Leu Lys Gly Glu Pro Gly Pro 
1               5                   10                  15      


Pro Gly Lys Pro Gly Pro Arg Gly Pro Pro Gly Pro Pro Gly Phe Pro 
            20                  25                  30          


Gly Lys Pro Gly Met Gly Lys Pro Gly Leu His Gly Gln Pro Gly Pro 
        35                  40                  45              


Ala Gly Pro Pro Gly Phe Ser Arg Met Gly Lys Ala Gly Pro Pro Gly 
    50                  55                  60                  


Leu Pro Gly Lys Val Gly Pro Pro Gly Gln Pro Gly Leu Arg Gly Glu 
65                  70                  75                  80  


Pro Gly Ile Arg Gly Asp Gln Gly Leu Arg Gly Pro Pro Gly Pro Pro 
                85                  90                  95      


Gly Leu Pro Gly Pro Ser Gly Ile Thr Ile Pro Gly Lys Pro Gly Ala 
            100                 105                 110         


Gln Gly Val Pro Gly Pro Pro Gly Phe Gln Gly Glu Pro Gly Pro Gln 
        115                 120                 125             


Gly Glu Pro Gly Pro Pro Gly Asp Arg Gly Leu Lys Gly Asp Asn Gly 
    130                 135                 140                 


Val Gly Gln Pro Gly Leu Pro Gly Ala Pro Gly Gln Gly Gly Ala Pro 
145                 150                 155                 160 


Gly Pro Pro Gly Leu Pro Gly Pro Ala Gly Leu Gly Lys Pro Gly Leu 
                165                 170                 175     


Asp Gly Leu Pro Gly Ala Pro Gly Asp Lys Gly Glu Ser Gly Pro Pro 
            180                 185                 190         


Gly Val Pro Gly Pro Arg Gly Glu Pro Gly Ala Val Gly Pro Lys Gly 
        195                 200                 205             


Pro Pro Gly Val Asp Gly Val Gly Val Pro Gly Ala Ala Gly Leu Pro 
    210                 215                 220                 


Gly Pro Gln Gly Pro Ser Gly Ala Lys Gly Glu Pro Gly Thr Arg Gly 
225                 230                 235                 240 


Pro Pro Gly Leu Ile Gly Pro Thr Gly Tyr Gly Met Pro Gly Leu Pro 
                245                 250                 255     


Gly Pro Lys Gly Asp Arg Gly Pro Ala Gly Val Pro Gly Leu Leu Gly 
            260                 265                 270         


Asp Arg Gly Glu Pro Gly Glu Asp Gly Glu Pro Gly Glu Gln Gly Pro 
        275                 280                 285             


Gln Gly Leu Gly Gly Pro Pro Gly Leu Pro Gly Ser Ala Gly Leu Pro 
    290                 295                 300                 


Gly Arg Arg Gly Pro Pro Gly Pro Lys Gly Glu Ala Gly Pro Gly Gly 
305                 310                 315                 320 


Pro Pro Gly Val Pro Gly Ile Arg Gly Asp Gln Gly Pro Ser Gly Leu 
                325                 330                 335     


Ala Gly Lys Pro Gly Val Pro Gly Glu Arg Gly Leu Pro Gly Ala His 
            340                 345                 350         


Gly Pro Pro Gly Pro Thr Gly Pro Lys Gly Glu Pro Gly Phe Thr Gly 
        355                 360                 365             


Arg Pro Gly Gly Pro Gly Val Ala Gly Ala Leu Gly Gln Lys Gly Asp 
    370                 375                 380                 


Leu Gly Leu Pro Gly Gln Pro Gly Leu Arg Gly Pro Ser Gly Ile Pro 
385                 390                 395                 400 


Gly Leu Gln Gly Pro Ala Gly Pro Ile Gly Pro Gln Gly Leu Pro Gly 
                405                 410                 415     


Leu Lys Gly Glu Pro Gly Leu Pro Gly Pro Pro Gly Glu Gly Arg Ala 
            420                 425                 430         


Gly Glu Pro Gly Thr Ala Gly Pro Thr Gly Pro Pro Gly Val Pro Gly 
        435                 440                 445             


Ser Pro Gly Ile Thr Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro 
    450                 455                 460                 


Pro Gly Ala Pro Gly Ala Phe Asp Glu Thr Gly Ile Ala Gly Leu His 
465                 470                 475                 480 


Leu Pro Asn Gly Gly Val Glu Gly Ala Val Leu Gly Lys Gly Gly Lys 
                485                 490                 495     


Pro Gln Phe Gly Leu Gly Glu Leu Ser Ala His Ala Thr Pro Ala Phe 
            500                 505                 510         


Thr Ala Val Leu Thr Ser Pro Phe Pro Ala Ser Gly Met Pro Val Lys 
        515                 520                 525             


Phe Asp Arg Thr Leu Tyr Asn Gly His Ser Gly Tyr Asn Pro Ala Thr 
    530                 535                 540                 


Gly Ile Phe Thr Cys Pro Val Gly Gly Val Tyr Tyr Phe Ala Tyr His 
545                 550                 555                 560 


Val His Val Lys Gly Thr Asn Val Trp Val Ala Leu Tyr Lys Asn Asn 
                565                 570                 575     


Val Pro Ala Thr Tyr Thr Tyr Asp Glu Tyr Lys Lys Gly Tyr Leu Asp 
            580                 585                 590         


Gln Ala Ser Gly Gly Ala Val Leu Gln Leu Arg Pro Asn Asp Gln Val 
        595                 600                 605             


Trp Val Gln Met Pro Ser Asp Gln Ala Asn Gly Leu Tyr Ser Thr Glu 
    610                 615                 620                 


Tyr Ile His Ser Ser Phe Ser Gly Phe Leu Leu Cys Pro Thr 
625                 630                 635             


<210>  3355
<211>  112
<212>  PRT
<213>  Homo Sapiens

<400>  3355

Met Ala Trp Thr Ala Arg Asp Arg Gly Ala Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Cys Leu Cys Ala Ala Gln Arg Gly Pro Pro Gly Glu Gln Gly 
            20                  25                  30          


Pro Pro Gly Pro Pro Gly Pro Pro Gly Val Pro Gly Ile Asp Gly Ile 
        35                  40                  45              


Asp Gly Asp Arg Gly Pro Lys Gly Pro Pro Gly Pro Pro Gly Pro Ala 
    50                  55                  60                  


Gly Glu Pro Gly Lys Pro Gly Ala Pro Gly Lys Pro Gly Thr Pro Gly 
65                  70                  75                  80  


Ala Asp Ala Gly Val Gln Trp His Asp Leu Gly Ser Leu Gln Pro Leu 
                85                  90                  95      


Pro Pro Gly Phe Lys Arg Phe Ser Cys Leu Ser Leu Gln Leu Pro Glu 
            100                 105                 110         


<210>  3356
<211>  678
<212>  PRT
<213>  Homo Sapiens

<400>  3356

Met Ala Trp Thr Ala Arg Asp Arg Gly Ala Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Cys Leu Cys Ala Ala Gln Arg Gly Pro Pro Gly Glu Gln Gly 
            20                  25                  30          


Pro Pro Gly Pro Pro Gly Pro Pro Gly Val Pro Gly Ile Asp Gly Ile 
        35                  40                  45              


Asp Gly Asp Arg Gly Pro Lys Gly Pro Pro Gly Pro Pro Gly Pro Ala 
    50                  55                  60                  


Gly Glu Pro Gly Lys Pro Gly Ala Pro Gly Lys Pro Gly Thr Pro Gly 
65                  70                  75                  80  


Ala Asp Gly Leu Thr Gly Pro Asp Gly Ser Pro Gly Ser Ile Gly Ser 
                85                  90                  95      


Lys Gly Gln Lys Gly Glu Pro Gly Val Pro Gly Ser Arg Gly Phe Pro 
            100                 105                 110         


Gly Arg Gly Ile Pro Gly Pro Pro Gly Pro Pro Gly Thr Ala Gly Leu 
        115                 120                 125             


Pro Gly Glu Leu Gly Arg Val Gly Pro Val Gly Asp Pro Gly Arg Arg 
    130                 135                 140                 


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly Thr Ile Gly 
145                 150                 155                 160 


Phe His Asp Gly Asp Pro Leu Cys Pro Asn Ala Cys Pro Pro Gly Arg 
                165                 170                 175     


Ser Gly Tyr Pro Gly Leu Pro Gly Met Arg Gly His Lys Gly Ala Lys 
            180                 185                 190         


Gly Glu Ile Gly Glu Pro Gly Arg Gln Gly His Lys Gly Glu Glu Gly 
        195                 200                 205             


Asp Gln Gly Glu Leu Gly Glu Val Gly Ala Gln Gly Pro Pro Gly Ala 
    210                 215                 220                 


Gln Gly Leu Arg Gly Ile Thr Gly Ile Val Gly Asp Lys Gly Glu Lys 
225                 230                 235                 240 


Gly Ala Arg Gly Leu Asp Gly Glu Pro Gly Pro Gln Gly Leu Pro Gly 
                245                 250                 255     


Ala Pro Gly Asp Gln Gly Gln Arg Gly Pro Pro Gly Glu Ala Gly Pro 
            260                 265                 270         


Lys Gly Asp Arg Gly Ala Glu Gly Ala Arg Gly Ile Pro Gly Leu Pro 
        275                 280                 285             


Gly Pro Lys Gly Asp Thr Gly Leu Pro Gly Val Asp Gly Arg Asp Gly 
    290                 295                 300                 


Ile Pro Gly Met Pro Gly Thr Lys Gly Glu Pro Gly Lys Pro Gly Pro 
305                 310                 315                 320 


Pro Gly Asp Ala Gly Leu Gln Gly Leu Pro Gly Val Pro Gly Ile Pro 
                325                 330                 335     


Gly Ala Lys Gly Val Ala Gly Glu Lys Gly Ser Thr Gly Ala Pro Gly 
            340                 345                 350         


Lys Pro Gly Gln Met Gly Asn Ser Gly Lys Pro Gly Gln Gln Gly Pro 
        355                 360                 365             


Pro Gly Glu Val Gly Pro Arg Gly Pro Gln Gly Leu Pro Gly Ser Arg 
    370                 375                 380                 


Gly Glu Leu Gly Pro Val Gly Ser Pro Gly Leu Pro Gly Lys Leu Gly 
385                 390                 395                 400 


Ser Leu Gly Ser Pro Gly Leu Pro Gly Leu Pro Gly Pro Pro Gly Leu 
                405                 410                 415     


Pro Gly Met Lys Gly Asp Arg Gly Val Val Gly Glu Pro Gly Pro Lys 
            420                 425                 430         


Gly Glu Gln Gly Ala Ser Gly Glu Glu Gly Glu Ala Gly Glu Arg Gly 
        435                 440                 445             


Glu Leu Gly Asp Ile Gly Leu Pro Gly Pro Lys Gly Ser Ala Gly Asn 
    450                 455                 460                 


Pro Gly Glu Pro Gly Leu Arg Gly Pro Glu Gly Ser Arg Gly Leu Pro 
465                 470                 475                 480 


Gly Val Glu Gly Pro Arg Gly Pro Pro Gly Pro Arg Gly Val Gln Gly 
                485                 490                 495     


Glu Gln Gly Ala Thr Gly Leu Pro Gly Val Gln Gly Pro Pro Gly Arg 
            500                 505                 510         


Ala Pro Thr Asp Gln His Ile Lys Gln Val Cys Met Arg Val Ile Gln 
        515                 520                 525             


Glu His Phe Ala Glu Met Ala Ala Ser Leu Lys Arg Pro Asp Ser Gly 
    530                 535                 540                 


Ala Thr Gly Leu Pro Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Pro 
545                 550                 555                 560 


Pro Gly Glu Asn Gly Phe Pro Gly Gln Met Gly Ile Arg Gly Leu Pro 
                565                 570                 575     


Gly Ile Lys Gly Pro Pro Gly Ala Leu Gly Leu Arg Gly Pro Lys Gly 
            580                 585                 590         


Asp Leu Gly Glu Lys Gly Glu Arg Gly Pro Pro Gly Arg Gly Pro Asn 
        595                 600                 605             


Gly Leu Pro Gly Ala Ile Gly Leu Pro Gly Asp Pro Gly Pro Ala Ser 
    610                 615                 620                 


Tyr Gly Arg Asn Gly Arg Asp Gly Glu Arg Gly Pro Pro Gly Val Ala 
625                 630                 635                 640 


Gly Ile Pro Gly Val Pro Gly Pro Pro Gly Pro Pro Gly Leu Pro Gly 
                645                 650                 655     


Phe Cys Glu Pro Ala Ser Cys Thr Met Gln Ala Gly Gln Arg Ala Phe 
            660                 665                 670         


Asn Lys Gly Pro Asp Pro 
        675             


<210>  3357
<211>  921
<212>  PRT
<213>  Homo Sapiens

<400>  3357

Met Lys Thr Cys Trp Lys Ile Pro Val Phe Phe Phe Val Cys Ser Phe 
1               5                   10                  15      


Leu Glu Pro Trp Ala Ser Ala Ala Val Lys Arg Arg Pro Arg Phe Pro 
            20                  25                  30          


Val Asn Ser Asn Ser Asn Gly Gly Asn Glu Leu Cys Pro Lys Ile Arg 
        35                  40                  45              


Ile Gly Gln Asp Asp Leu Pro Gly Phe Asp Leu Ile Ser Gln Phe Gln 
    50                  55                  60                  


Val Asp Lys Ala Ala Ser Arg Arg Ala Ile Gln Arg Val Val Gly Ser 
65                  70                  75                  80  


Ala Thr Leu Gln Val Ala Tyr Lys Leu Gly Asn Asn Val Asp Phe Arg 
                85                  90                  95      


Ile Pro Thr Arg Asn Leu Tyr Pro Ser Gly Leu Pro Glu Glu Tyr Ser 
            100                 105                 110         


Phe Leu Thr Thr Phe Arg Met Thr Gly Ser Thr Leu Lys Lys Asn Trp 
        115                 120                 125             


Asn Ile Trp Gln Ile Gln Asp Ser Ser Gly Lys Glu Gln Val Gly Ile 
    130                 135                 140                 


Lys Ile Asn Gly Gln Thr Gln Ser Val Val Phe Ser Tyr Lys Gly Leu 
145                 150                 155                 160 


Asp Gly Ser Leu Gln Thr Ala Ala Phe Ser Asn Leu Ser Ser Leu Phe 
                165                 170                 175     


Asp Ser Gln Trp His Lys Ile Met Ile Gly Val Glu Arg Ser Ser Ala 
            180                 185                 190         


Thr Leu Phe Val Asp Cys Asn Arg Ile Glu Ser Leu Pro Ile Lys Pro 
        195                 200                 205             


Arg Gly Pro Ile Asp Ile Asp Gly Phe Ala Val Leu Gly Lys Leu Ala 
    210                 215                 220                 


Asp Asn Pro Gln Val Ser Val Pro Phe Glu Leu Gln Trp Met Leu Ile 
225                 230                 235                 240 


His Cys Asp Pro Leu Arg Pro Arg Arg Glu Thr Cys His Glu Leu Pro 
                245                 250                 255     


Ala Arg Ile Thr Pro Ser Gln Thr Thr Asp Glu Arg Gly Pro Pro Gly 
            260                 265                 270         


Glu Gln Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Val Pro Gly Ile 
        275                 280                 285             


Asp Gly Ile Asp Gly Asp Arg Gly Pro Lys Gly Pro Pro Gly Pro Pro 
    290                 295                 300                 


Gly Pro Ala Gly Glu Pro Gly Lys Pro Gly Ala Pro Gly Lys Pro Gly 
305                 310                 315                 320 


Thr Pro Gly Ala Asp Gly Leu Thr Gly Pro Asp Gly Ser Pro Gly Ser 
                325                 330                 335     


Ile Gly Ser Lys Gly Gln Lys Gly Glu Pro Gly Val Pro Gly Ser Arg 
            340                 345                 350         


Gly Phe Pro Gly Arg Gly Ile Pro Gly Pro Pro Gly Pro Pro Gly Thr 
        355                 360                 365             


Ala Gly Leu Pro Gly Glu Leu Gly Arg Val Gly Pro Val Gly Asp Pro 
    370                 375                 380                 


Gly Arg Arg Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly 
385                 390                 395                 400 


Thr Ile Gly Phe His Asp Gly Asp Pro Leu Cys Pro Asn Ala Cys Pro 
                405                 410                 415     


Pro Gly Arg Ser Gly Tyr Pro Gly Leu Pro Gly Met Arg Gly His Lys 
            420                 425                 430         


Gly Ala Lys Gly Glu Ile Gly Glu Pro Gly Arg Gln Gly His Lys Gly 
        435                 440                 445             


Glu Glu Gly Asp Gln Gly Glu Leu Gly Glu Val Gly Ala Gln Gly Pro 
    450                 455                 460                 


Pro Gly Ala Gln Gly Leu Arg Gly Ile Thr Gly Ile Val Gly Asp Lys 
465                 470                 475                 480 


Gly Glu Lys Gly Ala Arg Gly Leu Asp Gly Glu Pro Gly Pro Gln Gly 
                485                 490                 495     


Leu Pro Gly Ala Pro Gly Asp Gln Gly Gln Arg Gly Pro Pro Gly Glu 
            500                 505                 510         


Ala Gly Pro Lys Gly Asp Arg Gly Ala Glu Gly Ala Arg Gly Ile Pro 
        515                 520                 525             


Gly Leu Pro Gly Pro Lys Gly Asp Thr Gly Leu Pro Gly Val Asp Gly 
    530                 535                 540                 


Arg Asp Gly Ile Pro Gly Met Pro Gly Thr Lys Gly Glu Pro Gly Lys 
545                 550                 555                 560 


Pro Gly Pro Pro Gly Asp Ala Gly Leu Gln Gly Leu Pro Gly Val Pro 
                565                 570                 575     


Gly Ile Pro Gly Ala Lys Gly Val Ala Gly Glu Lys Gly Ser Thr Gly 
            580                 585                 590         


Ala Pro Gly Lys Pro Gly Gln Met Gly Asn Ser Gly Lys Pro Gly Gln 
        595                 600                 605             


Gln Gly Pro Pro Gly Glu Val Gly Pro Arg Gly Pro Gln Gly Leu Pro 
    610                 615                 620                 


Gly Ser Arg Gly Glu Leu Gly Pro Val Gly Ser Pro Gly Leu Pro Gly 
625                 630                 635                 640 


Lys Leu Gly Ser Leu Gly Ser Pro Gly Leu Pro Gly Leu Pro Gly Pro 
                645                 650                 655     


Pro Gly Leu Pro Gly Met Lys Gly Asp Arg Gly Val Val Gly Glu Pro 
            660                 665                 670         


Gly Pro Lys Gly Glu Gln Gly Ala Ser Gly Glu Glu Gly Glu Ala Gly 
        675                 680                 685             


Glu Arg Gly Glu Leu Gly Asp Ile Gly Leu Pro Gly Pro Lys Gly Ser 
    690                 695                 700                 


Ala Gly Asn Pro Gly Glu Pro Gly Leu Arg Gly Pro Glu Gly Ser Arg 
705                 710                 715                 720 


Gly Leu Pro Gly Val Glu Gly Pro Arg Gly Pro Pro Gly Pro Arg Gly 
                725                 730                 735     


Val Gln Gly Glu Gln Gly Ala Thr Gly Leu Pro Gly Val Gln Gly Pro 
            740                 745                 750         


Pro Gly Arg Ala Pro Thr Asp Gln His Ile Lys Gln Val Cys Met Arg 
        755                 760                 765             


Val Ile Gln Glu His Phe Ala Glu Met Ala Ala Ser Leu Lys Arg Pro 
    770                 775                 780                 


Asp Ser Gly Ala Thr Gly Leu Pro Gly Arg Pro Gly Pro Pro Gly Pro 
785                 790                 795                 800 


Pro Gly Pro Pro Gly Glu Asn Gly Phe Pro Gly Gln Met Gly Ile Arg 
                805                 810                 815     


Gly Leu Pro Gly Ile Lys Gly Pro Pro Gly Ala Leu Gly Leu Arg Gly 
            820                 825                 830         


Pro Lys Gly Asp Leu Gly Glu Lys Gly Glu Arg Gly Pro Pro Gly Arg 
        835                 840                 845             


Gly Pro Asn Gly Leu Pro Gly Ala Ile Gly Leu Pro Gly Asp Pro Gly 
    850                 855                 860                 


Pro Ala Ser Tyr Gly Arg Asn Gly Arg Asp Gly Glu Arg Gly Pro Pro 
865                 870                 875                 880 


Gly Val Ala Gly Ile Pro Gly Val Pro Gly Pro Pro Gly Pro Pro Gly 
                885                 890                 895     


Leu Pro Gly Phe Cys Glu Pro Ala Ser Cys Thr Met Gln Ala Gly Gln 
            900                 905                 910         


Arg Ala Phe Asn Lys Gly Pro Asp Pro 
        915                 920     


<210>  3358
<211>  328
<212>  PRT
<213>  Homo Sapiens

<400>  3358

Met Lys Thr Cys Trp Lys Ile Pro Val Phe Phe Phe Val Cys Ser Phe 
1               5                   10                  15      


Leu Glu Pro Trp Ala Ser Ala Ala Val Lys Arg Arg Pro Arg Phe Pro 
            20                  25                  30          


Val Asn Ser Asn Ser Asn Gly Gly Asn Glu Leu Cys Pro Lys Ile Arg 
        35                  40                  45              


Ile Gly Gln Asp Asp Leu Pro Gly Phe Asp Leu Ile Ser Gln Phe Gln 
    50                  55                  60                  


Val Asp Lys Ala Ala Ser Arg Arg Ala Ile Gln Arg Val Val Gly Ser 
65                  70                  75                  80  


Ala Thr Leu Gln Val Ala Tyr Lys Leu Gly Asn Asn Val Asp Phe Arg 
                85                  90                  95      


Ile Pro Thr Arg Asn Leu Tyr Pro Ser Gly Leu Pro Glu Glu Tyr Ser 
            100                 105                 110         


Phe Leu Thr Thr Phe Arg Met Thr Gly Ser Thr Leu Lys Lys Asn Trp 
        115                 120                 125             


Asn Ile Trp Gln Ile Gln Asp Ser Ser Gly Lys Glu Gln Val Gly Ile 
    130                 135                 140                 


Lys Ile Asn Gly Gln Thr Gln Ser Val Val Phe Ser Tyr Lys Gly Leu 
145                 150                 155                 160 


Asp Gly Ser Leu Gln Thr Ala Ala Phe Ser Asn Leu Ser Ser Leu Phe 
                165                 170                 175     


Asp Ser Gln Trp His Lys Ile Met Ile Gly Val Glu Arg Ser Ser Ala 
            180                 185                 190         


Thr Leu Phe Val Asp Cys Asn Arg Ile Glu Ser Leu Pro Ile Lys Pro 
        195                 200                 205             


Arg Gly Pro Ile Asp Ile Asp Gly Phe Ala Val Leu Gly Lys Leu Ala 
    210                 215                 220                 


Asp Asn Pro Gln Val Ser Val Pro Phe Glu Leu Gln Trp Met Leu Ile 
225                 230                 235                 240 


His Cys Asp Pro Leu Arg Pro Arg Arg Glu Thr Cys His Glu Leu Pro 
                245                 250                 255     


Ala Arg Ile Thr Pro Ser Gln Thr Thr Asp Glu Arg Gly Pro Pro Gly 
            260                 265                 270         


Glu Gln Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Val Pro Gly Ile 
        275                 280                 285             


Asp Gly Ile Asp Gly Asp Arg Gly Pro Lys Gly Pro Pro Gly Pro Pro 
    290                 295                 300                 


Gly Pro Ala Gly Glu Pro Gly Lys Pro Gly Ala Pro Gly Lys Pro Gly 
305                 310                 315                 320 


Thr Pro Gly Ala Asp Thr Ser Pro 
                325             


<210>  3359
<211>  689
<212>  PRT
<213>  Homo Sapiens

<400>  3359

Met Ala Ala Ala Thr Ala Ser Pro Arg Ser Leu Leu Val Leu Leu Gln 
1               5                   10                  15      


Val Val Val Leu Ala Leu Ala Gln Ile Arg Gly Pro Pro Gly Glu Arg 
            20                  25                  30          


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Val Pro Gly Ser Asp Gly 
        35                  40                  45              


Ile Asp Gly Asp Asn Gly Pro Pro Gly Lys Ala Gly Pro Pro Gly Pro 
    50                  55                  60                  


Lys Gly Glu Pro Gly Lys Ala Gly Pro Asp Gly Pro Asp Gly Lys Pro 
65                  70                  75                  80  


Gly Ile Asp Gly Leu Thr Gly Ala Lys Gly Glu Pro Gly Pro Met Gly 
                85                  90                  95      


Ile Pro Gly Val Lys Gly Gln Pro Gly Leu Pro Gly Pro Pro Gly Leu 
            100                 105                 110         


Pro Gly Pro Gly Phe Ala Gly Pro Pro Gly Pro Pro Gly Pro Val Gly 
        115                 120                 125             


Leu Pro Gly Glu Ile Gly Ile Arg Gly Pro Lys Gly Asp Pro Gly Pro 
    130                 135                 140                 


Asp Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly Lys Pro Gly Arg Pro 
145                 150                 155                 160 


Gly Thr Ile Gln Gly Leu Glu Gly Ser Ala Asp Phe Leu Cys Pro Thr 
                165                 170                 175     


Asn Cys Pro Pro Gly Met Lys Gly Pro Pro Gly Leu Gln Gly Val Lys 
            180                 185                 190         


Gly His Ala Gly Lys Arg Gly Ile Leu Gly Asp Pro Gly His Gln Gly 
        195                 200                 205             


Lys Pro Gly Pro Lys Gly Asp Val Gly Ala Ser Gly Glu Gln Gly Ile 
    210                 215                 220                 


Pro Gly Pro Pro Gly Pro Gln Gly Ile Arg Gly Tyr Pro Gly Met Ala 
225                 230                 235                 240 


Gly Pro Lys Gly Glu Thr Gly Pro His Gly Tyr Lys Gly Met Val Gly 
                245                 250                 255     


Ala Ile Gly Ala Thr Gly Pro Pro Gly Glu Glu Gly Pro Arg Gly Pro 
            260                 265                 270         


Pro Gly Arg Ala Gly Glu Lys Gly Asp Glu Gly Ser Pro Gly Ile Arg 
        275                 280                 285             


Gly Pro Gln Gly Ile Thr Gly Pro Lys Gly Ala Thr Gly Pro Pro Gly 
    290                 295                 300                 


Ile Asn Gly Lys Asp Gly Thr Pro Gly Thr Pro Gly Met Lys Gly Ser 
305                 310                 315                 320 


Ala Gly Gln Ala Gly Gln Pro Gly Ser Pro Gly His Gln Gly Leu Ala 
                325                 330                 335     


Gly Val Pro Gly Gln Pro Gly Thr Lys Gly Gly Pro Gly Asp Gln Gly 
            340                 345                 350         


Glu Pro Gly Pro Gln Gly Leu Pro Gly Phe Ser Gly Pro Pro Gly Lys 
        355                 360                 365             


Glu Gly Glu Pro Gly Pro Arg Gly Glu Ile Gly Pro Gln Gly Ile Met 
    370                 375                 380                 


Gly Gln Lys Gly Asp Gln Gly Glu Arg Gly Pro Val Gly Gln Pro Gly 
385                 390                 395                 400 


Pro Gln Gly Arg Gln Gly Pro Lys Gly Glu Gln Gly Pro Pro Gly Ile 
                405                 410                 415     


Pro Gly Pro Gln Gly Leu Pro Gly Val Lys Gly Asp Lys Gly Ser Pro 
            420                 425                 430         


Gly Lys Thr Gly Pro Arg Gly Lys Val Gly Asp Pro Gly Val Ala Gly 
        435                 440                 445             


Leu Pro Gly Glu Lys Gly Glu Lys Gly Glu Ser Gly Glu Pro Gly Pro 
    450                 455                 460                 


Lys Gly Gln Gln Gly Val Arg Gly Glu Pro Gly Tyr Pro Gly Pro Ser 
465                 470                 475                 480 


Gly Asp Ala Gly Ala Pro Gly Val Gln Gly Tyr Pro Gly Pro Pro Gly 
                485                 490                 495     


Pro Arg Gly Leu Ala Gly Asn Arg Gly Val Pro Gly Gln Pro Gly Arg 
            500                 505                 510         


Gln Gly Val Glu Gly Arg Asp Ala Thr Asp Gln His Ile Val Asp Val 
        515                 520                 525             


Ala Leu Lys Met Leu Gln Glu Gln Leu Ala Glu Val Ala Val Ser Ala 
    530                 535                 540                 


Lys Arg Glu Ala Leu Gly Ala Val Gly Met Met Gly Pro Pro Gly Pro 
545                 550                 555                 560 


Pro Gly Pro Pro Gly Tyr Pro Gly Lys Gln Gly Pro His Gly His Pro 
                565                 570                 575     


Gly Pro Arg Gly Val Pro Gly Ile Val Gly Ala Val Gly Gln Ile Gly 
            580                 585                 590         


Asn Thr Gly Pro Lys Gly Lys Arg Gly Glu Lys Gly Asp Pro Gly Glu 
        595                 600                 605             


Val Gly Arg Gly His Pro Gly Met Pro Gly Pro Pro Gly Ile Pro Gly 
    610                 615                 620                 


Leu Pro Gly Arg Pro Gly Gln Ala Ile Asn Gly Lys Asp Gly Asp Arg 
625                 630                 635                 640 


Gly Ser Pro Gly Ala Pro Gly Glu Ala Gly Arg Pro Gly Leu Pro Gly 
                645                 650                 655     


Pro Val Gly Leu Pro Gly Phe Cys Glu Pro Ala Ala Cys Leu Gly Ala 
            660                 665                 670         


Ser Ala Tyr Ala Ser Ala Arg Leu Thr Glu Pro Gly Ser Ile Lys Gly 
        675                 680                 685             


Pro 
    


<210>  3360
<211>  83
<212>  PRT
<213>  Homo Sapiens

<400>  3360

Met Ala Ala Ala Thr Ala Ser Pro Arg Ser Leu Leu Val Leu Leu Gln 
1               5                   10                  15      


Val Val Val Leu Ala Leu Ala Gln Ile Arg Gly Pro Pro Gly Glu Arg 
            20                  25                  30          


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Val Pro Gly Ser Asp Gly 
        35                  40                  45              


Ile Asp Gly Pro Pro Gly Pro Val Gly Leu Pro Gly Glu Ile Gly Ile 
    50                  55                  60                  


Arg Gly Pro Lys Gly Asp Pro Gly Pro Asp Gly Pro Ser Gly Pro Pro 
65                  70                  75                  80  


Gly Pro Pro 
            


<210>  3361
<211>  11
<212>  PRT
<213>  Homo Sapiens

<400>  3361

Met Gly Ile Pro Gly Val Lys Gly Gln Pro Gly 
1               5                   10      


<210>  3362
<211>  143
<212>  PRT
<213>  Homo Sapiens

<400>  3362

Met Gly Ile Pro Gly Val Lys Gly Gln Pro Gly Leu Pro Gly Pro Pro 
1               5                   10                  15      


Gly Leu Pro Gly Pro Gly Phe Ala Gly Pro Pro Gly Pro Pro Gly Pro 
            20                  25                  30          


Val Gly Leu Pro Gly Glu Ile Gly Ile Arg Gly Pro Lys Gly Asp Pro 
        35                  40                  45              


Gly Pro Asp Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly Lys Pro Gly 
    50                  55                  60                  


Arg Pro Gly Thr Ile Gln Gly Leu Glu Gly Ser Ala Asp Phe Leu Cys 
65                  70                  75                  80  


Pro Thr Asn Cys Pro Pro Gly Met Lys Gly Pro Pro Gly Leu Gln Gly 
                85                  90                  95      


Val Lys Gly His Ala Gly Lys Arg Gly Ile Leu Gly Asp Pro Gly His 
            100                 105                 110         


Gln Gly Lys Pro Gly Pro Lys Gly Asp Val Gly Ala Ser Gly Glu Gln 
        115                 120                 125             


Gly Ile Pro Gly Pro Pro Gly Pro Gln Gly Ile Arg Gly Tyr Pro 
    130                 135                 140             


<210>  3363
<211>  684
<212>  PRT
<213>  Homo Sapiens

<400>  3363

Met Ala Gly Pro Arg Ala Cys Ala Pro Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Gly Glu Leu Leu Ala Ala Ala Gly Ala Gln Arg Val Gly Leu Pro Gly 
            20                  25                  30          


Pro Pro Gly Pro Pro Gly Pro Pro Gly Lys Pro Gly Gln Asp Gly Ile 
        35                  40                  45              


Asp Gly Glu Ala Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro Lys 
    50                  55                  60                  


Gly Ala Pro Gly Lys Pro Gly Lys Pro Gly Glu Ala Gly Leu Pro Gly 
65                  70                  75                  80  


Leu Pro Gly Val Asp Gly Leu Thr Gly Arg Asp Gly Pro Pro Gly Pro 
                85                  90                  95      


Lys Gly Ala Pro Gly Glu Arg Gly Ser Leu Gly Pro Pro Gly Pro Pro 
            100                 105                 110         


Gly Leu Gly Gly Lys Gly Leu Pro Gly Pro Pro Gly Glu Ala Gly Val 
        115                 120                 125             


Ser Gly Pro Pro Gly Gly Ile Gly Leu Arg Gly Pro Pro Gly Pro Ser 
    130                 135                 140                 


Gly Leu Pro Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
145                 150                 155                 160 


His Pro Gly Val Leu Pro Glu Gly Ala Thr Asp Leu Gln Cys Pro Ser 
                165                 170                 175     


Ile Cys Pro Pro Gly Pro Pro Gly Pro Pro Gly Met Pro Gly Phe Lys 
            180                 185                 190         


Gly Pro Thr Gly Tyr Lys Gly Glu Gln Gly Glu Val Gly Lys Asp Gly 
        195                 200                 205             


Glu Lys Gly Asp Pro Gly Pro Pro Gly Pro Ala Gly Leu Pro Gly Ser 
    210                 215                 220                 


Val Gly Leu Gln Gly Pro Arg Gly Leu Arg Gly Leu Pro Gly Pro Leu 
225                 230                 235                 240 


Gly Pro Pro Gly Asp Arg Gly Pro Ile Gly Phe Arg Gly Pro Pro Gly 
                245                 250                 255     


Ile Pro Gly Ala Pro Gly Lys Ala Gly Asp Arg Gly Glu Arg Gly Pro 
            260                 265                 270         


Glu Gly Phe Arg Gly Pro Lys Gly Asp Leu Gly Arg Pro Gly Pro Lys 
        275                 280                 285             


Gly Thr Pro Gly Val Ala Gly Pro Ser Gly Glu Pro Gly Met Pro Gly 
    290                 295                 300                 


Lys Asp Gly Gln Asn Gly Val Pro Gly Leu Asp Gly Gln Lys Gly Glu 
305                 310                 315                 320 


Ala Gly Arg Asn Gly Ala Pro Gly Glu Lys Gly Pro Asn Gly Leu Pro 
                325                 330                 335     


Gly Leu Pro Gly Arg Ala Gly Ser Lys Gly Glu Lys Gly Glu Arg Gly 
            340                 345                 350         


Arg Ala Gly Glu Leu Gly Glu Ala Gly Pro Ser Gly Glu Pro Gly Val 
        355                 360                 365             


Pro Gly Asp Ala Gly Met Pro Gly Glu Arg Gly Glu Ala Gly His Arg 
    370                 375                 380                 


Gly Ser Ala Gly Ala Leu Gly Pro Gln Gly Pro Pro Gly Ala Pro Gly 
385                 390                 395                 400 


Val Arg Gly Phe Gln Gly Gln Lys Gly Ser Met Gly Asp Pro Gly Leu 
                405                 410                 415     


Pro Gly Pro Gln Gly Leu Arg Gly Asp Val Gly Asp Arg Gly Pro Gly 
            420                 425                 430         


Gly Ala Ala Gly Pro Lys Gly Asp Gln Gly Ile Ala Gly Ser Asp Gly 
        435                 440                 445             


Leu Pro Gly Asp Lys Gly Glu Leu Gly Pro Ser Gly Leu Val Gly Pro 
    450                 455                 460                 


Lys Gly Glu Ser Gly Ser Arg Gly Glu Leu Gly Pro Lys Gly Thr Gln 
465                 470                 475                 480 


Gly Pro Asn Gly Thr Ser Gly Val Gln Gly Val Pro Gly Pro Pro Gly 
                485                 490                 495     


Pro Leu Gly Leu Gln Gly Val Pro Gly Val Pro Gly Ile Thr Gly Lys 
            500                 505                 510         


Pro Gly Val Pro Gly Lys Glu Ala Ser Glu Gln Arg Ile Arg Glu Leu 
        515                 520                 525             


Cys Gly Gly Met Ile Ser Glu Gln Ile Ala Gln Leu Ala Ala His Leu 
    530                 535                 540                 


Arg Lys Pro Leu Ala Pro Gly Ser Ile Gly Arg Pro Gly Pro Ala Gly 
545                 550                 555                 560 


Pro Pro Gly Pro Pro Gly Pro Pro Gly Ser Ile Gly His Pro Gly Ala 
                565                 570                 575     


Arg Gly Pro Pro Gly Tyr Arg Gly Pro Thr Gly Glu Leu Gly Asp Pro 
            580                 585                 590         


Gly Pro Arg Gly Asn Gln Gly Asp Arg Gly Asp Lys Gly Ala Ala Gly 
        595                 600                 605             


Ala Gly Leu Asp Gly Pro Glu Gly Asp Gln Gly Pro Gln Gly Pro Gln 
    610                 615                 620                 


Gly Val Pro Gly Thr Ser Lys Asp Gly Gln Asp Gly Ala Pro Gly Glu 
625                 630                 635                 640 


Pro Gly Pro Pro Gly Asp Pro Gly Leu Pro Gly Ala Ile Gly Ala Gln 
                645                 650                 655     


Gly Thr Pro Gly Ile Cys Asp Thr Ser Ala Cys Gln Gly Ala Val Leu 
            660                 665                 670         


Gly Gly Val Gly Glu Lys Ser Gly Ser Arg Ser Ser 
        675                 680                 


<210>  3364
<211>  191
<212>  PRT
<213>  Homo Sapiens

<400>  3364

Met Trp Trp Ser Ser Thr Gln Asn Ala Gly Thr Glu Gly Glu Ala Gly 
1               5                   10                  15      


Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro Lys Gly Ala Pro Gly Lys 
            20                  25                  30          


Pro Gly Lys Pro Gly Glu Ala Gly Leu Pro Gly Leu Pro Gly Val Asp 
        35                  40                  45              


Gly Leu Thr Gly Arg Asp Gly Pro Pro Gly Pro Lys Gly Ala Pro Gly 
    50                  55                  60                  


Glu Arg Gly Ser Leu Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Lys 
65                  70                  75                  80  


Gly Leu Pro Gly Pro Pro Gly Glu Ala Gly Val Ser Gly Pro Pro Gly 
                85                  90                  95      


Gly Ile Gly Leu Arg Gly Pro Pro Gly Pro Ser Gly Leu Pro Gly Leu 
            100                 105                 110         


Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly His Pro Gly Val Leu 
        115                 120                 125             


Pro Glu Gly Ala Thr Asp Leu Gln Cys Pro Ser Ile Cys Pro Pro Gly 
    130                 135                 140                 


Pro Pro Gly Pro Pro Gly Met Pro Gly Phe Lys Gly Pro Thr Gly Tyr 
145                 150                 155                 160 


Lys Gly Glu Gln Gly Glu Val Gly Lys Asp Gly Glu Lys Gly Asp Pro 
                165                 170                 175     


Gly Pro Pro Gly Pro Ala Gly Leu Pro Gly Ser Val Gly Leu Gln 
            180                 185                 190     


<210>  3365
<211>  277
<212>  PRT
<213>  Homo Sapiens

<400>  3365

Met Asn Gly Phe Ala Ser Leu Leu Arg Arg Asn Gln Phe Ile Leu Leu 
1               5                   10                  15      


Val Leu Phe Leu Leu Gln Ile Gln Ser Leu Gly Leu Asp Ile Asp Ser 
            20                  25                  30          


Arg Pro Thr Ala Glu Val Cys Ala Thr His Thr Ile Ser Pro Gly Pro 
        35                  40                  45              


Lys Gly Asp Asp Gly Glu Lys Gly Asp Pro Gly Glu Glu Gly Lys His 
    50                  55                  60                  


Gly Lys Val Gly Arg Met Gly Pro Lys Gly Ile Lys Gly Glu Leu Gly 
65                  70                  75                  80  


Asp Met Gly Asp Gln Gly Asn Ile Gly Lys Thr Gly Pro Ile Gly Lys 
                85                  90                  95      


Lys Gly Asp Lys Gly Glu Lys Gly Leu Leu Gly Ile Pro Gly Glu Lys 
            100                 105                 110         


Gly Lys Ala Gly Thr Val Cys Asp Cys Gly Arg Tyr Arg Lys Phe Val 
        115                 120                 125             


Gly Gln Leu Asp Ile Ser Ile Ala Arg Leu Lys Thr Ser Met Lys Phe 
    130                 135                 140                 


Val Lys Asn Val Ile Ala Gly Ile Arg Glu Thr Glu Glu Lys Phe Tyr 
145                 150                 155                 160 


Tyr Ile Val Gln Glu Glu Lys Asn Tyr Arg Glu Ser Leu Thr His Cys 
                165                 170                 175     


Arg Ile Arg Gly Gly Met Leu Ala Met Pro Lys Asp Glu Ala Ala Asn 
            180                 185                 190         


Thr Leu Ile Ala Asp Tyr Val Ala Lys Ser Gly Phe Phe Arg Val Phe 
        195                 200                 205             


Ile Gly Val Asn Asp Leu Glu Arg Glu Gly Gln Tyr Met Phe Thr Asp 
    210                 215                 220                 


Asn Thr Pro Leu Gln Asn Tyr Ser Asn Trp Asn Glu Gly Glu Pro Ser 
225                 230                 235                 240 


Asp Pro Tyr Gly His Glu Asp Cys Val Glu Met Leu Ser Ser Gly Arg 
                245                 250                 255     


Trp Asn Asp Thr Glu Cys His Leu Thr Met Tyr Phe Val Cys Glu Phe 
            260                 265                 270         


Ile Lys Lys Lys Lys 
        275         


<210>  3366
<211>  123
<212>  PRT
<213>  Homo Sapiens

<400>  3366

Met Lys Lys Gln Arg Gly Val Gly Val Leu Pro Ala Leu Arg Met Arg 
1               5                   10                  15      


Gly Asn Leu Ala Leu Val Gly Val Leu Ile Ser Leu Ala Phe Leu Ser 
            20                  25                  30          


Leu Leu Pro Ser Gly His Pro Gln Pro Ala Gly Asp Asp Ala Cys Ser 
        35                  40                  45              


Val Gln Ile Leu Val Pro Gly Leu Lys Gly Asp Ala Gly Glu Lys Gly 
    50                  55                  60                  


Asp Lys Gly Ala Pro Gly Arg Pro Gly Arg Val Gly Pro Thr Gly Glu 
65                  70                  75                  80  


Lys Gly Asp Met Gly Asp Lys Gly Gln Lys Gly Ser Val Gly Arg His 
                85                  90                  95      


Gly Lys Ile Gly Pro Ile Gly Ser Lys Gly Glu Lys Gly Asp Ser Gly 
            100                 105                 110         


Asp Ile Gly Pro Pro Gly Pro Asn Gly Glu Pro 
        115                 120             


<210>  3367
<211>  285
<212>  PRT
<213>  Homo Sapiens

<400>  3367

Met Lys Lys Gln Arg Gly Val Gly Val Leu Pro Ala Leu Arg Met Arg 
1               5                   10                  15      


Gly Asn Leu Ala Leu Val Gly Val Leu Ile Ser Leu Ala Phe Leu Ser 
            20                  25                  30          


Leu Leu Pro Ser Gly His Pro Gln Pro Ala Gly Asp Asp Ala Cys Ser 
        35                  40                  45              


Val Gln Ile Leu Val Pro Gly Leu Lys Gly Asp Ala Gly Glu Lys Gly 
    50                  55                  60                  


Asp Lys Gly Ala Pro Gly Arg Pro Gly Arg Val Gly Pro Thr Gly Glu 
65                  70                  75                  80  


Lys Gly Asp Met Gly Asp Lys Gly Gln Lys Gly Ser Val Gly Arg His 
                85                  90                  95      


Gly Lys Ile Gly Pro Ile Gly Ser Lys Gly Glu Lys Gly Asp Ser Gly 
            100                 105                 110         


Asp Ile Gly Pro Pro Gly Pro Asn Gly Glu Pro Gly Leu Pro Cys Glu 
        115                 120                 125             


Cys Ser Gln Leu Arg Lys Ala Ile Gly Glu Met Asp Asn Gln Val Ser 
    130                 135                 140                 


Gln Leu Thr Ser Glu Leu Lys Phe Ile Lys Asn Ala Val Ala Gly Val 
145                 150                 155                 160 


Arg Glu Thr Glu Ser Lys Ile Tyr Leu Leu Val Lys Glu Glu Lys Arg 
                165                 170                 175     


Tyr Ala Asp Ala Gln Leu Ser Cys Gln Gly Arg Gly Gly Thr Leu Ser 
            180                 185                 190         


Met Pro Lys Asp Glu Ala Ala Asn Gly Leu Met Ala Ala Tyr Leu Ala 
        195                 200                 205             


Gln Ala Gly Leu Ala Arg Val Phe Ile Gly Ile Asn Asp Leu Glu Lys 
    210                 215                 220                 


Glu Gly Ala Phe Val Tyr Ser Asp His Ser Pro Met Arg Thr Phe Asn 
225                 230                 235                 240 


Lys Trp Arg Ser Gly Glu Pro Asn Asn Ala Tyr Asp Glu Glu Asp Cys 
                245                 250                 255     


Val Glu Met Val Ala Ser Gly Gly Trp Asn Asp Val Ala Cys His Thr 
            260                 265                 270         


Thr Met Tyr Phe Met Cys Glu Phe Asp Lys Glu Asn Met 
        275                 280                 285 


<210>  3368
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  3368

Met Arg Gly Asn Leu Ala Leu Val Gly Val Leu Ile Ser Leu Ala Phe 
1               5                   10                  15      


Leu Ser Leu Leu Pro Ser Gly His Pro Gln Pro Ala Gly Asp Asp Ala 
            20                  25                  30          


Cys Ser Val Gln Ile Leu Val Pro Gly Leu Lys Gly Asp Ala Gly Glu 
        35                  40                  45              


Lys Gly Asp Lys Gly Ala Pro Gly Arg Pro Gly Arg Val Gly Pro Thr 
    50                  55                  60                  


Gly Glu Lys Gly Asp Met Gly Asp Lys Gly Gln Lys Gly Ser Val Gly 
65                  70                  75                  80  


Arg His Gly Lys Ile Gly Pro Ile Gly Ser Lys Gly Glu Lys Gly Asp 
                85                  90                  95      


Ser Gly Asp Ile Gly Pro Pro Gly Pro Asn Gly Glu Pro Ala Pro Ser 
            100                 105                 110         


Ala Pro Gln Arg 
        115     


<210>  3369
<211>  271
<212>  PRT
<213>  Homo Sapiens

<400>  3369

Met Arg Gly Asn Leu Ala Leu Val Gly Val Leu Ile Ser Leu Ala Phe 
1               5                   10                  15      


Leu Ser Leu Leu Pro Ser Gly His Pro Gln Pro Ala Gly Asp Asp Ala 
            20                  25                  30          


Cys Ser Val Gln Ile Leu Val Pro Gly Leu Lys Gly Asp Ala Gly Glu 
        35                  40                  45              


Lys Gly Asp Lys Gly Ala Pro Gly Arg Pro Gly Arg Val Gly Pro Thr 
    50                  55                  60                  


Gly Glu Lys Gly Asp Met Gly Asp Lys Gly Gln Lys Gly Ser Val Gly 
65                  70                  75                  80  


Arg His Gly Lys Ile Gly Pro Ile Gly Ser Lys Gly Glu Lys Gly Asp 
                85                  90                  95      


Ser Gly Asp Ile Gly Pro Pro Gly Pro Asn Gly Glu Pro Gly Leu Pro 
            100                 105                 110         


Cys Glu Cys Ser Gln Leu Arg Lys Ala Ile Gly Glu Met Asp Asn Gln 
        115                 120                 125             


Val Ser Gln Leu Thr Ser Glu Leu Lys Phe Ile Lys Asn Ala Val Ala 
    130                 135                 140                 


Gly Val Arg Glu Thr Glu Ser Lys Ile Tyr Leu Leu Val Lys Glu Glu 
145                 150                 155                 160 


Lys Arg Tyr Ala Asp Ala Gln Leu Ser Cys Gln Gly Arg Gly Gly Thr 
                165                 170                 175     


Leu Ser Met Pro Lys Asp Glu Ala Ala Asn Gly Leu Met Ala Ala Tyr 
            180                 185                 190         


Leu Ala Gln Ala Gly Leu Ala Arg Val Phe Ile Gly Ile Asn Asp Leu 
        195                 200                 205             


Glu Lys Glu Gly Ala Phe Val Tyr Ser Asp His Ser Pro Met Arg Thr 
    210                 215                 220                 


Phe Asn Lys Trp Arg Ser Gly Glu Pro Asn Asn Ala Tyr Asp Glu Glu 
225                 230                 235                 240 


Asp Cys Val Glu Met Val Ala Ser Gly Gly Trp Asn Asp Val Ala Cys 
                245                 250                 255     


His Thr Thr Met Tyr Phe Met Cys Glu Phe Asp Lys Glu Asn Met 
            260                 265                 270     


<210>  3370
<211>  247
<212>  PRT
<213>  Homo Sapiens

<400>  3370

Met Arg Gly Asn Leu Ala Leu Val Gly Val Leu Ile Ser Leu Ala Phe 
1               5                   10                  15      


Leu Ser Leu Leu Pro Ser Gly His Pro Gln Pro Ala Gly Asp Asp Ala 
            20                  25                  30          


Cys Ser Val Gln Ile Leu Val Pro Gly Leu Lys Gly Asp Ala Gly Glu 
        35                  40                  45              


Lys Gly Asp Lys Gly Ala Pro Gly Arg Pro Gly Arg Val Gly Pro Thr 
    50                  55                  60                  


Gly Glu Lys Gly Glu Lys Gly Asp Ser Gly Asp Ile Gly Pro Pro Gly 
65                  70                  75                  80  


Pro Asn Gly Glu Pro Gly Leu Pro Cys Glu Cys Ser Gln Leu Arg Lys 
                85                  90                  95      


Ala Ile Gly Glu Met Asp Asn Gln Val Ser Gln Leu Thr Ser Glu Leu 
            100                 105                 110         


Lys Phe Ile Lys Asn Ala Val Ala Gly Val Arg Glu Thr Glu Ser Lys 
        115                 120                 125             


Ile Tyr Leu Leu Val Lys Glu Glu Lys Arg Tyr Ala Asp Ala Gln Leu 
    130                 135                 140                 


Ser Cys Gln Gly Arg Gly Gly Thr Leu Ser Met Pro Lys Asp Glu Ala 
145                 150                 155                 160 


Ala Asn Gly Leu Met Ala Ala Tyr Leu Ala Gln Ala Gly Leu Ala Arg 
                165                 170                 175     


Val Phe Ile Gly Ile Asn Asp Leu Glu Lys Glu Gly Ala Phe Val Tyr 
            180                 185                 190         


Ser Asp His Ser Pro Met Arg Thr Phe Asn Lys Trp Arg Ser Gly Glu 
        195                 200                 205             


Pro Asn Asn Ala Tyr Asp Glu Glu Asp Cys Val Glu Met Val Ala Ser 
    210                 215                 220                 


Gly Gly Trp Asn Asp Val Ala Cys His Thr Thr Met Tyr Phe Met Cys 
225                 230                 235                 240 


Glu Phe Asp Lys Glu Asn Met 
                245         


<210>  3371
<211>  268
<212>  PRT
<213>  Homo Sapiens

<400>  3371

Met Thr Pro Ala Leu Cys Arg Ser Ser Ser Leu Ala Ser Lys Gly Met 
1               5                   10                  15      


Arg Glu Arg Arg Glu Thr Lys Ala Pro Pro Asp Gly Leu Glu Glu Ser 
            20                  25                  30          


Ala Pro Arg Glu Lys Lys Gln Ser Gln Pro Val Val Thr Ala Ser Asp 
        35                  40                  45              


Ile Ser Lys Arg Lys Cys Thr Ser Ser Phe Val Glu Met Gly Ser Gln 
    50                  55                  60                  


Gly Asp Met Gly Asp Lys Gly Gln Lys Gly Ser Val Gly Arg His Gly 
65                  70                  75                  80  


Lys Ile Gly Pro Ile Gly Ser Lys Gly Glu Lys Gly Asp Ser Gly Asp 
                85                  90                  95      


Ile Gly Pro Pro Gly Pro Asn Gly Glu Pro Gly Leu Pro Cys Glu Cys 
            100                 105                 110         


Ser Gln Leu Arg Lys Ala Ile Gly Glu Met Asp Asn Gln Val Ser Gln 
        115                 120                 125             


Leu Thr Ser Glu Leu Lys Phe Ile Lys Asn Ala Val Ala Gly Val Arg 
    130                 135                 140                 


Glu Thr Glu Ser Lys Ile Tyr Leu Leu Val Lys Glu Glu Lys Arg Tyr 
145                 150                 155                 160 


Ala Asp Ala Gln Leu Ser Cys Gln Gly Arg Gly Gly Thr Leu Ser Met 
                165                 170                 175     


Pro Lys Asp Glu Ala Ala Asn Gly Leu Met Ala Ala Tyr Leu Ala Gln 
            180                 185                 190         


Ala Gly Leu Ala Arg Val Phe Ile Gly Ile Asn Asp Leu Glu Lys Glu 
        195                 200                 205             


Gly Ala Phe Val Tyr Ser Asp His Ser Pro Met Arg Thr Phe Asn Lys 
    210                 215                 220                 


Trp Arg Ser Gly Glu Pro Asn Asn Ala Tyr Asp Glu Glu Asp Cys Val 
225                 230                 235                 240 


Glu Met Val Ala Ser Gly Gly Trp Asn Asp Val Ala Cys His Thr Thr 
                245                 250                 255     


Met Tyr Phe Met Cys Glu Phe Asp Lys Glu Asn Met 
            260                 265             


<210>  3372
<211>  245
<212>  PRT
<213>  Homo Sapiens

<400>  3372

Met Trp Trp Val Pro Pro Ser Pro Tyr Gly Cys Leu Pro Cys Ala Leu 
1               5                   10                  15      


Pro Gly Asp Ala Gly Glu Lys Gly Asp Lys Gly Ala Pro Gly Arg Pro 
            20                  25                  30          


Gly Arg Val Gly Pro Thr Gly Glu Lys Gly Asp Met Gly Asp Lys Gly 
        35                  40                  45              


Gln Lys Gly Ser Val Gly Arg His Gly Lys Ile Gly Pro Ile Gly Ser 
    50                  55                  60                  


Lys Gly Glu Lys Gly Asp Ser Gly Asp Ile Gly Pro Pro Gly Pro Asn 
65                  70                  75                  80  


Gly Glu Pro Gly Leu Pro Cys Glu Cys Ser Gln Leu Arg Lys Ala Ile 
                85                  90                  95      


Gly Glu Met Asp Asn Gln Val Ser Gln Leu Thr Ser Glu Leu Lys Phe 
            100                 105                 110         


Ile Lys Asn Ala Val Ala Gly Val Arg Glu Thr Glu Ser Lys Ile Tyr 
        115                 120                 125             


Leu Leu Val Lys Glu Glu Lys Arg Tyr Ala Asp Ala Gln Leu Ser Cys 
    130                 135                 140                 


Gln Gly Arg Gly Gly Thr Leu Ser Met Pro Lys Asp Glu Ala Ala Asn 
145                 150                 155                 160 


Gly Leu Met Ala Ala Tyr Leu Ala Gln Ala Gly Leu Ala Arg Val Phe 
                165                 170                 175     


Ile Gly Ile Asn Asp Leu Glu Lys Glu Gly Ala Phe Val Tyr Ser Asp 
            180                 185                 190         


His Ser Pro Met Arg Thr Phe Asn Lys Trp Arg Ser Gly Glu Pro Asn 
        195                 200                 205             


Asn Ala Tyr Asp Glu Glu Asp Cys Val Glu Met Val Ala Ser Gly Gly 
    210                 215                 220                 


Trp Asn Asp Val Ala Cys His Thr Thr Met Tyr Phe Met Cys Glu Phe 
225                 230                 235                 240 


Asp Lys Glu Asn Met 
                245 


<210>  3373
<211>  221
<212>  PRT
<213>  Homo Sapiens

<400>  3373

Met Trp Trp Val Pro Pro Ser Pro Tyr Gly Cys Leu Pro Cys Ala Leu 
1               5                   10                  15      


Pro Gly Asp Ala Gly Glu Lys Gly Asp Lys Gly Ala Pro Gly Arg Pro 
            20                  25                  30          


Gly Arg Val Gly Pro Thr Gly Glu Lys Gly Glu Lys Gly Asp Ser Gly 
        35                  40                  45              


Asp Ile Gly Pro Pro Gly Pro Asn Gly Glu Pro Gly Leu Pro Cys Glu 
    50                  55                  60                  


Cys Ser Gln Leu Arg Lys Ala Ile Gly Glu Met Asp Asn Gln Val Ser 
65                  70                  75                  80  


Gln Leu Thr Ser Glu Leu Lys Phe Ile Lys Asn Ala Val Ala Gly Val 
                85                  90                  95      


Arg Glu Thr Glu Ser Lys Ile Tyr Leu Leu Val Lys Glu Glu Lys Arg 
            100                 105                 110         


Tyr Ala Asp Ala Gln Leu Ser Cys Gln Gly Arg Gly Gly Thr Leu Ser 
        115                 120                 125             


Met Pro Lys Asp Glu Ala Ala Asn Gly Leu Met Ala Ala Tyr Leu Ala 
    130                 135                 140                 


Gln Ala Gly Leu Ala Arg Val Phe Ile Gly Ile Asn Asp Leu Glu Lys 
145                 150                 155                 160 


Glu Gly Ala Phe Val Tyr Ser Asp His Ser Pro Met Arg Thr Phe Asn 
                165                 170                 175     


Lys Trp Arg Ser Gly Glu Pro Asn Asn Ala Tyr Asp Glu Glu Asp Cys 
            180                 185                 190         


Val Glu Met Val Ala Ser Gly Gly Trp Asn Asp Val Ala Cys His Thr 
        195                 200                 205             


Thr Met Tyr Phe Met Cys Glu Phe Asp Lys Glu Asn Met 
    210                 215                 220     


<210>  3374
<211>  221
<212>  PRT
<213>  Homo Sapiens

<400>  3374

Met Trp Trp Val Pro Pro Ser Pro Tyr Gly Cys Leu Pro Cys Ala Leu 
1               5                   10                  15      


Pro Gly Asp Met Gly Asp Lys Gly Gln Lys Gly Ser Val Gly Arg His 
            20                  25                  30          


Gly Lys Ile Gly Pro Ile Gly Ser Lys Gly Glu Lys Gly Asp Ser Gly 
        35                  40                  45              


Asp Ile Gly Pro Pro Gly Pro Asn Gly Glu Pro Gly Leu Pro Cys Glu 
    50                  55                  60                  


Cys Ser Gln Leu Arg Lys Ala Ile Gly Glu Met Asp Asn Gln Val Ser 
65                  70                  75                  80  


Gln Leu Thr Ser Glu Leu Lys Phe Ile Lys Asn Ala Val Ala Gly Val 
                85                  90                  95      


Arg Glu Thr Glu Ser Lys Ile Tyr Leu Leu Val Lys Glu Glu Lys Arg 
            100                 105                 110         


Tyr Ala Asp Ala Gln Leu Ser Cys Gln Gly Arg Gly Gly Thr Leu Ser 
        115                 120                 125             


Met Pro Lys Asp Glu Ala Ala Asn Gly Leu Met Ala Ala Tyr Leu Ala 
    130                 135                 140                 


Gln Ala Gly Leu Ala Arg Val Phe Ile Gly Ile Asn Asp Leu Glu Lys 
145                 150                 155                 160 


Glu Gly Ala Phe Val Tyr Ser Asp His Ser Pro Met Arg Thr Phe Asn 
                165                 170                 175     


Lys Trp Arg Ser Gly Glu Pro Asn Asn Ala Tyr Asp Glu Glu Asp Cys 
            180                 185                 190         


Val Glu Met Val Ala Ser Gly Gly Trp Asn Asp Val Ala Cys His Thr 
        195                 200                 205             


Thr Met Tyr Phe Met Cys Glu Phe Asp Lys Glu Asn Met 
    210                 215                 220     


<210>  3375
<211>  197
<212>  PRT
<213>  Homo Sapiens

<400>  3375

Met Trp Trp Val Pro Pro Ser Pro Tyr Gly Cys Leu Pro Cys Ala Leu 
1               5                   10                  15      


Pro Gly Glu Lys Gly Asp Ser Gly Asp Ile Gly Pro Pro Gly Pro Asn 
            20                  25                  30          


Gly Glu Pro Gly Leu Pro Cys Glu Cys Ser Gln Leu Arg Lys Ala Ile 
        35                  40                  45              


Gly Glu Met Asp Asn Gln Val Ser Gln Leu Thr Ser Glu Leu Lys Phe 
    50                  55                  60                  


Ile Lys Asn Ala Val Ala Gly Val Arg Glu Thr Glu Ser Lys Ile Tyr 
65                  70                  75                  80  


Leu Leu Val Lys Glu Glu Lys Arg Tyr Ala Asp Ala Gln Leu Ser Cys 
                85                  90                  95      


Gln Gly Arg Gly Gly Thr Leu Ser Met Pro Lys Asp Glu Ala Ala Asn 
            100                 105                 110         


Gly Leu Met Ala Ala Tyr Leu Ala Gln Ala Gly Leu Ala Arg Val Phe 
        115                 120                 125             


Ile Gly Ile Asn Asp Leu Glu Lys Glu Gly Ala Phe Val Tyr Ser Asp 
    130                 135                 140                 


His Ser Pro Met Arg Thr Phe Asn Lys Trp Arg Ser Gly Glu Pro Asn 
145                 150                 155                 160 


Asn Ala Tyr Asp Glu Glu Asp Cys Val Glu Met Val Ala Ser Gly Gly 
                165                 170                 175     


Trp Asn Asp Val Ala Cys His Thr Thr Met Tyr Phe Met Cys Glu Phe 
            180                 185                 190         


Asp Lys Glu Asn Met 
        195         


<210>  3376
<211>  622
<212>  PRT
<213>  Homo Sapiens

<400>  3376

Met Ala Ala Ala Pro Arg Ala Gly Arg Arg Arg Gly Gln Pro Leu Leu 
1               5                   10                  15      


Ala Leu Leu Leu Leu Leu Leu Ala Pro Leu Pro Pro Gly Ala Pro Pro 
            20                  25                  30          


Gly Ala Asp Ala Tyr Phe Pro Glu Glu Arg Trp Ser Pro Glu Ser Pro 
        35                  40                  45              


Leu Gln Ala Pro Arg Val Leu Ile Ala Leu Leu Ala Arg Asn Ala Ala 
    50                  55                  60                  


His Ala Leu Pro Thr Thr Leu Gly Ala Leu Glu Arg Leu Arg His Pro 
65                  70                  75                  80  


Arg Glu Arg Thr Ala Leu Trp Val Ala Thr Asp His Asn Met Asp Asn 
                85                  90                  95      


Thr Ser Thr Val Leu Arg Glu Trp Leu Val Ala Val Lys Ser Leu Tyr 
            100                 105                 110         


His Ser Val Glu Trp Arg Pro Ala Glu Glu Pro Arg Ser Tyr Pro Asp 
        115                 120                 125             


Glu Glu Gly Pro Lys His Trp Ser Asp Ser Arg Tyr Glu His Val Met 
    130                 135                 140                 


Lys Leu Arg Gln Ala Ala Leu Lys Ser Ala Arg Asp Met Trp Ala Asp 
145                 150                 155                 160 


Tyr Ile Leu Phe Val Asp Ala Asp Asn Leu Ile Leu Asn Pro Asp Thr 
                165                 170                 175     


Leu Ser Leu Leu Ile Ala Glu Asn Lys Thr Val Val Ala Pro Met Leu 
            180                 185                 190         


Asp Ser Arg Ala Ala Tyr Ser Asn Phe Trp Cys Gly Met Thr Ser Gln 
        195                 200                 205             


Gly Tyr Tyr Lys Arg Thr Pro Ala Tyr Ile Pro Ile Arg Lys Arg Asp 
    210                 215                 220                 


Arg Arg Gly Cys Phe Ala Val Pro Met Val His Ser Thr Phe Leu Ile 
225                 230                 235                 240 


Asp Leu Arg Lys Ala Ala Ser Arg Asn Leu Ala Phe Tyr Pro Pro His 
                245                 250                 255     


Pro Asp Tyr Thr Trp Ser Phe Asp Asp Ile Ile Val Phe Ala Phe Ser 
            260                 265                 270         


Cys Lys Gln Ala Glu Val Gln Met Tyr Val Cys Asn Lys Glu Glu Tyr 
        275                 280                 285             


Gly Phe Leu Pro Val Pro Leu Arg Ala His Ser Thr Leu Gln Asp Glu 
    290                 295                 300                 


Ala Glu Ser Phe Met His Val Gln Leu Glu Val Met Val Lys His Pro 
305                 310                 315                 320 


Pro Ala Glu Pro Ser Arg Phe Ile Ser Ala Pro Thr Lys Thr Pro Asp 
                325                 330                 335     


Lys Met Gly Phe Asp Glu Val Phe Met Ile Asn Leu Arg Arg Arg Gln 
            340                 345                 350         


Asp Arg Arg Glu Arg Met Leu Arg Ala Leu Gln Ala Gln Glu Ile Glu 
        355                 360                 365             


Cys Arg Leu Val Glu Ala Val Asp Gly Lys Ala Met Asn Thr Ser Gln 
    370                 375                 380                 


Val Glu Ala Leu Gly Ile Gln Met Leu Pro Gly Tyr Arg Asp Pro Tyr 
385                 390                 395                 400 


His Gly Arg Pro Leu Thr Lys Gly Glu Leu Gly Cys Phe Leu Ser His 
                405                 410                 415     


Tyr Asn Ile Trp Lys Glu Val Val Asp Arg Gly Leu Gln Lys Ser Leu 
            420                 425                 430         


Val Phe Glu Asp Asp Leu Arg Phe Glu Ile Phe Phe Lys Arg Arg Leu 
        435                 440                 445             


Met Asn Leu Met Arg Asp Val Glu Arg Glu Gly Leu Asp Trp Asp Leu 
    450                 455                 460                 


Ile Tyr Val Gly Arg Lys Arg Met Gln Val Glu His Pro Glu Lys Ala 
465                 470                 475                 480 


Val Pro Arg Val Arg Asn Leu Val Glu Ala Asp Tyr Ser Tyr Trp Thr 
                485                 490                 495     


Leu Ala Tyr Val Ile Ser Leu Gln Gly Ala Arg Lys Leu Leu Ala Ala 
            500                 505                 510         


Glu Pro Leu Ser Lys Met Leu Pro Val Asp Glu Phe Leu Pro Val Met 
        515                 520                 525             


Phe Asp Lys His Pro Val Ser Glu Tyr Lys Ala His Phe Ser Leu Arg 
    530                 535                 540                 


Asn Leu His Ala Phe Ser Val Glu Pro Leu Leu Ile Tyr Pro Thr His 
545                 550                 555                 560 


Tyr Thr Gly Asp Asp Gly Tyr Val Ser Asp Thr Glu Thr Ser Val Val 
                565                 570                 575     


Trp Asn Asn Glu His Val Lys Thr Asp Trp Asp Arg Ala Lys Ser Gln 
            580                 585                 590         


Lys Met Arg Glu Gln Gln Ala Leu Ser Arg Glu Ala Lys Asn Ser Asp 
        595                 600                 605             


Val Leu Gln Ser Pro Leu Asp Ser Ala Ala Arg Asp Glu Leu 
    610                 615                 620         


<210>  3377
<211>  138
<212>  PRT
<213>  Homo Sapiens

<400>  3377

Met Asp Asn Thr Ser Thr Val Leu Arg Glu Trp Leu Val Ala Val Lys 
1               5                   10                  15      


Ser Leu Tyr His Ser Val Glu Trp Arg Pro Ala Glu Glu Pro Arg Ser 
            20                  25                  30          


Tyr Pro Asp Glu Glu Gly Pro Lys His Trp Ser Asp Ser Arg Tyr Glu 
        35                  40                  45              


His Val Met Lys Leu Arg Gln Ala Ala Leu Lys Ser Ala Arg Asp Met 
    50                  55                  60                  


Trp Ala Asp Tyr Ile Leu Phe Val Asp Ala Asp Asn Leu Ile Leu Asn 
65                  70                  75                  80  


Pro Asp Thr Leu Ser Leu Leu Ile Ala Glu Asn Lys Thr Val Val Ala 
                85                  90                  95      


Pro Met Leu Asp Ser Arg Ala Ala Tyr Ser Asn Phe Trp Cys Gly Met 
            100                 105                 110         


Thr Ser Gln Gly Tyr Tyr Lys Arg Thr Pro Ala Tyr Ile Pro Ile Arg 
        115                 120                 125             


Lys Arg Asp Arg Arg Gly Cys Phe Ala Val 
    130                 135             


<210>  3378
<211>  218
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3378

Xaa Lys Ala Ala Ser Arg Asn Leu Ala Phe Tyr Pro Pro His Pro Asp 
1               5                   10                  15      


Tyr Thr Trp Ser Phe Asp Asp Ile Ile Val Phe Ala Phe Ser Cys Lys 
            20                  25                  30          


Gln Ala Val Lys His Pro Pro Ala Glu Pro Ser Arg Phe Ile Ser Ala 
        35                  40                  45              


Pro Thr Lys Thr Pro Asp Lys Met Gly Phe Asp Glu Val Phe Met Ile 
    50                  55                  60                  


Asn Leu Arg Arg Arg Gln Asp Arg Arg Glu Arg Met Leu Arg Ala Leu 
65                  70                  75                  80  


Gln Ala Gln Glu Ile Glu Cys Arg Leu Val Glu Ala Val Asp Gly Lys 
                85                  90                  95      


Ala Met Asn Thr Ser Gln Val Glu Ala Leu Gly Ile Gln Met Leu Pro 
            100                 105                 110         


Gly Tyr Arg Asp Pro Tyr His Gly Arg Pro Leu Thr Lys Gly Glu Leu 
        115                 120                 125             


Gly Cys Phe Leu Ser His Tyr Asn Ile Trp Lys Glu Val Val Asp Arg 
    130                 135                 140                 


Gly Leu Gln Lys Ser Leu Val Phe Glu Asp Asp Leu Arg Phe Glu Ile 
145                 150                 155                 160 


Phe Phe Lys Arg Arg Leu Met Asn Leu Met Arg Asp Val Glu Arg Glu 
                165                 170                 175     


Gly Leu Asp Trp Asp Leu Ile Tyr Val Gly Arg Lys Arg Met Gln Val 
            180                 185                 190         


Glu His Pro Glu Lys Ala Val Pro Arg Val Arg Asn Leu Val Glu Ala 
        195                 200                 205             


Asp Tyr Ser Tyr Trp Thr Leu Ala Tyr Val 
    210                 215             


<210>  3379
<211>  626
<212>  PRT
<213>  Homo Sapiens

<400>  3379

Met Ala Ala Arg Pro Ala Ala Thr Leu Ala Trp Ser Leu Leu Leu Leu 
1               5                   10                  15      


Ser Ser Ala Leu Leu Arg Glu Gly Cys Arg Ala Arg Phe Val Ala Glu 
            20                  25                  30          


Arg Asp Ser Glu Asp Asp Gly Glu Glu Pro Val Val Phe Pro Glu Ser 
        35                  40                  45              


Pro Leu Gln Ser Pro Thr Val Leu Val Ala Val Leu Ala Arg Asn Ala 
    50                  55                  60                  


Ala His Thr Leu Pro His Phe Leu Gly Cys Leu Glu Arg Leu Asp Tyr 
65                  70                  75                  80  


Pro Lys Ser Arg Met Ala Ile Trp Ala Ala Thr Asp His Asn Val Asp 
                85                  90                  95      


Asn Thr Thr Glu Ile Phe Arg Glu Trp Leu Lys Asn Val Gln Arg Leu 
            100                 105                 110         


Tyr His Tyr Val Glu Trp Arg Pro Met Asp Glu Pro Glu Ser Tyr Pro 
        115                 120                 125             


Asp Glu Ile Gly Pro Lys His Trp Pro Thr Ser Arg Phe Ala His Val 
    130                 135                 140                 


Met Lys Leu Arg Gln Ala Ala Leu Arg Thr Ala Arg Glu Lys Trp Ser 
145                 150                 155                 160 


Asp Tyr Ile Leu Phe Ile Asp Val Asp Asn Phe Leu Thr Asn Pro Gln 
                165                 170                 175     


Thr Leu Asn Leu Leu Ile Ala Glu Asn Lys Thr Ile Val Ala Pro Met 
            180                 185                 190         


Leu Glu Ser Arg Gly Leu Tyr Ser Asn Phe Trp Cys Gly Ile Thr Pro 
        195                 200                 205             


Lys Gly Phe Tyr Lys Arg Thr Pro Asp Tyr Val Gln Ile Arg Glu Trp 
    210                 215                 220                 


Lys Arg Thr Gly Cys Phe Pro Val Pro Met Val His Ser Thr Phe Leu 
225                 230                 235                 240 


Ile Asp Leu Arg Lys Glu Ala Ser Asp Lys Leu Thr Phe Tyr Pro Pro 
                245                 250                 255     


His Gln Asp Tyr Thr Trp Thr Phe Asp Asp Ile Ile Val Phe Ala Phe 
            260                 265                 270         


Ser Ser Arg Gln Ala Gly Ile Gln Met Tyr Leu Cys Asn Arg Glu His 
        275                 280                 285             


Tyr Gly Tyr Leu Pro Ile Pro Leu Lys Pro His Gln Thr Leu Gln Glu 
    290                 295                 300                 


Asp Ile Glu Asn Leu Ile His Val Gln Ile Glu Ala Met Ile Asp Arg 
305                 310                 315                 320 


Pro Pro Met Glu Pro Ser Gln Tyr Val Ser Val Val Pro Lys Tyr Pro 
                325                 330                 335     


Asp Lys Met Gly Phe Asp Glu Ile Phe Met Ile Asn Leu Lys Arg Arg 
            340                 345                 350         


Lys Asp Arg Arg Asp Arg Met Leu Arg Thr Leu Tyr Glu Gln Glu Ile 
        355                 360                 365             


Glu Val Lys Ile Val Glu Ala Val Asp Gly Lys Ala Leu Asn Thr Ser 
    370                 375                 380                 


Gln Leu Lys Ala Leu Asn Ile Glu Met Leu Pro Gly Tyr Arg Asp Pro 
385                 390                 395                 400 


Tyr Ser Ser Arg Pro Leu Thr Arg Gly Glu Ile Gly Cys Phe Leu Ser 
                405                 410                 415     


His Tyr Ser Val Trp Lys Glu Val Ile Asp Arg Glu Leu Glu Lys Thr 
            420                 425                 430         


Leu Val Ile Glu Asp Asp Val Arg Phe Glu His Gln Phe Lys Lys Lys 
        435                 440                 445             


Leu Met Lys Leu Met Asp Asn Ile Asp Gln Ala Gln Leu Asp Trp Glu 
    450                 455                 460                 


Leu Ile Tyr Ile Gly Arg Lys Arg Met Gln Val Lys Glu Pro Glu Lys 
465                 470                 475                 480 


Ala Val Pro Asn Val Ala Asn Leu Val Glu Ala Asp Tyr Ser Tyr Trp 
                485                 490                 495     


Thr Leu Gly Tyr Val Ile Ser Leu Glu Gly Ala Gln Lys Leu Val Gly 
            500                 505                 510         


Ala Asn Pro Phe Gly Lys Met Leu Pro Val Asp Glu Phe Leu Pro Val 
        515                 520                 525             


Met Tyr Asn Lys His Pro Val Ala Glu Tyr Lys Glu Tyr Tyr Glu Ser 
    530                 535                 540                 


Arg Asp Leu Lys Ala Phe Ser Ala Glu Pro Leu Leu Ile Tyr Pro Thr 
545                 550                 555                 560 


His Tyr Thr Gly Gln Pro Gly Tyr Leu Ser Asp Thr Glu Thr Ser Thr 
                565                 570                 575     


Ile Trp Asp Asn Glu Thr Val Ala Thr Asp Trp Asp Arg Thr His Ala 
            580                 585                 590         


Trp Lys Ser Arg Lys Gln Ser Arg Ile Tyr Ser Asn Ala Lys Asn Thr 
        595                 600                 605             


Glu Ala Leu Pro Pro Pro Thr Ser Leu Asp Thr Val Pro Ser Arg Asp 
    610                 615                 620                 


Glu Leu 
625     


<210>  3380
<211>  363
<212>  PRT
<213>  Homo Sapiens

<400>  3380

Met Phe Ser Asp Cys Trp Leu Cys Pro Ser Leu Gly Ser Ser Gly Ile 
1               5                   10                  15      


Gln Met Tyr Leu Cys Asn Arg Glu His Tyr Gly Tyr Leu Pro Ile Pro 
            20                  25                  30          


Leu Lys Pro His Gln Thr Leu Gln Glu Asp Ile Glu Asn Leu Ile His 
        35                  40                  45              


Val Gln Ile Glu Ala Met Ile Asp Arg Pro Pro Met Glu Pro Ser Gln 
    50                  55                  60                  


Tyr Val Ser Val Val Pro Lys Tyr Pro Asp Lys Met Gly Phe Asp Glu 
65                  70                  75                  80  


Ile Phe Met Ile Asn Leu Lys Arg Arg Lys Asp Arg Arg Asp Arg Met 
                85                  90                  95      


Leu Arg Thr Leu Tyr Glu Gln Glu Ile Glu Val Lys Ile Val Glu Ala 
            100                 105                 110         


Val Asp Gly Lys Ala Leu Asn Thr Ser Gln Leu Lys Ala Leu Asn Ile 
        115                 120                 125             


Glu Met Leu Pro Gly Tyr Arg Asp Pro Tyr Ser Ser Arg Pro Leu Thr 
    130                 135                 140                 


Arg Gly Glu Ile Gly Cys Phe Leu Ser His Tyr Ser Val Trp Lys Glu 
145                 150                 155                 160 


Val Ile Asp Arg Glu Leu Glu Lys Thr Leu Val Ile Glu Asp Asp Val 
                165                 170                 175     


Arg Phe Glu His Gln Phe Lys Lys Lys Leu Met Lys Leu Met Asp Asn 
            180                 185                 190         


Ile Asp Gln Ala Gln Leu Asp Trp Glu Leu Ile Tyr Ile Gly Arg Lys 
        195                 200                 205             


Arg Met Gln Val Lys Glu Pro Glu Lys Ala Val Pro Asn Val Ala Asn 
    210                 215                 220                 


Leu Val Glu Ala Asp Tyr Ser Tyr Trp Thr Leu Gly Tyr Val Ile Ser 
225                 230                 235                 240 


Leu Glu Gly Ala Gln Lys Leu Val Gly Ala Asn Pro Phe Gly Lys Met 
                245                 250                 255     


Leu Pro Val Asp Glu Phe Leu Pro Val Met Tyr Asn Lys His Pro Val 
            260                 265                 270         


Ala Glu Tyr Lys Glu Tyr Tyr Glu Ser Arg Asp Leu Lys Ala Phe Ser 
        275                 280                 285             


Ala Glu Pro Leu Leu Ile Tyr Pro Thr His Tyr Thr Gly Gln Pro Gly 
    290                 295                 300                 


Tyr Leu Ser Asp Thr Glu Thr Ser Thr Ile Trp Asp Asn Glu Thr Val 
305                 310                 315                 320 


Ala Thr Asp Trp Asp Arg Thr His Ala Trp Lys Ser Arg Lys Gln Ser 
                325                 330                 335     


Arg Ile Tyr Ser Asn Ala Lys Asn Thr Glu Ala Leu Pro Pro Pro Thr 
            340                 345                 350         


Ser Leu Asp Thr Val Pro Ser Arg Asp Glu Leu 
        355                 360             


<210>  3381
<211>  234
<212>  PRT
<213>  Homo Sapiens

<400>  3381

Met Leu Pro Gly Tyr Arg Asp Pro Tyr Ser Ser Arg Pro Leu Thr Arg 
1               5                   10                  15      


Gly Glu Ile Gly Cys Phe Leu Ser His Tyr Ser Val Trp Lys Glu Val 
            20                  25                  30          


Ile Asp Arg Glu Leu Glu Lys Thr Leu Val Ile Glu Asp Asp Val Arg 
        35                  40                  45              


Phe Glu His Gln Phe Lys Lys Lys Leu Met Lys Leu Met Asp Asn Ile 
    50                  55                  60                  


Asp Gln Ala Gln Leu Asp Trp Glu Leu Ile Tyr Ile Gly Arg Lys Arg 
65                  70                  75                  80  


Met Gln Val Lys Glu Pro Glu Lys Ala Val Pro Asn Val Ala Asn Leu 
                85                  90                  95      


Val Glu Ala Asp Tyr Ser Tyr Trp Thr Leu Gly Tyr Val Ile Ser Leu 
            100                 105                 110         


Glu Gly Ala Gln Lys Leu Val Gly Ala Asn Pro Phe Gly Lys Met Leu 
        115                 120                 125             


Pro Val Asp Glu Phe Leu Pro Val Met Tyr Asn Lys His Pro Val Ala 
    130                 135                 140                 


Glu Tyr Lys Glu Tyr Tyr Glu Ser Arg Asp Leu Lys Ala Phe Ser Ala 
145                 150                 155                 160 


Glu Pro Leu Leu Ile Tyr Pro Thr His Tyr Thr Gly Gln Pro Gly Tyr 
                165                 170                 175     


Leu Ser Asp Thr Glu Thr Ser Thr Ile Trp Asp Asn Glu Thr Val Ala 
            180                 185                 190         


Thr Asp Trp Asp Arg Thr His Ala Trp Lys Ser Arg Lys Gln Ser Arg 
        195                 200                 205             


Ile Tyr Ser Asn Ala Lys Asn Thr Glu Ala Leu Pro Pro Pro Thr Ser 
    210                 215                 220                 


Leu Asp Thr Val Pro Ser Arg Asp Glu Leu 
225                 230                 


<210>  3382
<211>  194
<212>  PRT
<213>  Homo Sapiens

<400>  3382

Ile Ser Gly Leu Leu Cys Tyr Ser Ala Gly Cys Leu Ala Leu Pro Ser 
1               5                   10                  15      


Leu Asp Gln Lys Lys Arg Gly Gly His Lys Ala Cys Cys Leu Leu Thr 
            20                  25                  30          


Pro Pro Pro Pro Pro Leu Phe Pro Pro Pro Phe Phe Arg Gly Gly Arg 
        35                  40                  45              


Ser Pro Gly Pro Pro Gly Leu Pro Gly Lys Thr Gly Pro Lys Gly Glu 
    50                  55                  60                  


Lys Gly Glu Leu Gly Arg Pro Gly Arg Lys Gly Arg Pro Gly Pro Pro 
65                  70                  75                  80  


Gly Val Pro Gly Met Pro Gly Pro Ile Gly Trp Pro Gly Pro Glu Gly 
                85                  90                  95      


Pro Arg Gly Glu Lys Gly Asp Leu Gly Met Met Gly Leu Pro Gly Ser 
            100                 105                 110         


Arg Gly Pro Met Gly Ser Lys Gly Tyr Pro Gly Ser Arg Gly Glu Lys 
        115                 120                 125             


Gly Ser Arg Gly Glu Lys Gly Asp Leu Gly Pro Lys Gly Glu Lys Gly 
    130                 135                 140                 


Phe Pro Gly Phe Pro Gly Met Leu Gly Gln Lys Gly Glu Met Gly Pro 
145                 150                 155                 160 


Lys Gly Glu Pro Gly Ile Ala Gly His Arg Gly Pro Thr Gly Arg Pro 
                165                 170                 175     


Gly Lys Arg Gly Lys Gln Gly Gln Lys Gly Asp Ser Gly Val Met Gly 
            180                 185                 190         


Pro Pro 
        


<210>  3383
<211>  445
<212>  PRT
<213>  Homo Sapiens

<400>  3383

Met Thr Gly Ser Ser Phe Ser Leu Ala His Leu Leu Ile Ile Ser Gly 
1               5                   10                  15      


Leu Leu Cys Tyr Ser Ala Gly Cys Leu Ala Leu Pro Ser Leu Asp Gln 
            20                  25                  30          


Lys Lys Arg Gly Gly His Lys Ala Cys Cys Leu Leu Thr Pro Pro Pro 
        35                  40                  45              


Pro Pro Leu Phe Pro Pro Pro Phe Phe Arg Gly Gly Arg Ser Pro Leu 
    50                  55                  60                  


Leu Ser Pro Asp Met Lys Asn Leu Met Leu Glu Leu Glu Thr Ser Gln 
65                  70                  75                  80  


Ser Pro Cys Met Gln Gly Ser Leu Gly Ser Pro Gly Pro Pro Gly Pro 
                85                  90                  95      


Gln Gly Pro Pro Gly Leu Pro Gly Lys Thr Gly Pro Lys Gly Glu Lys 
            100                 105                 110         


Gly Glu Leu Gly Arg Pro Gly Arg Lys Gly Arg Pro Gly Pro Pro Gly 
        115                 120                 125             


Val Pro Gly Met Pro Gly Pro Ile Gly Trp Pro Gly Pro Glu Gly Pro 
    130                 135                 140                 


Arg Gly Glu Lys Gly Asp Leu Gly Met Met Gly Leu Pro Gly Ser Arg 
145                 150                 155                 160 


Gly Pro Met Gly Ser Lys Gly Tyr Pro Gly Ser Arg Gly Glu Lys Gly 
                165                 170                 175     


Ser Arg Gly Glu Lys Gly Asp Leu Gly Pro Lys Gly Glu Lys Gly Phe 
            180                 185                 190         


Pro Gly Phe Pro Gly Met Leu Gly Gln Lys Gly Glu Met Gly Pro Lys 
        195                 200                 205             


Gly Glu Pro Gly Ile Ala Gly His Arg Gly Pro Thr Gly Arg Pro Gly 
    210                 215                 220                 


Lys Arg Gly Lys Gln Gly Gln Lys Gly Asp Ser Gly Val Met Gly Pro 
225                 230                 235                 240 


Pro Gly Lys Pro Gly Pro Ser Gly Gln Pro Gly Arg Pro Gly Pro Pro 
                245                 250                 255     


Gly Pro Pro Pro Ala Gly Gln Leu Ile Met Gly Pro Lys Gly Glu Arg 
            260                 265                 270         


Gly Phe Pro Gly Pro Pro Gly Arg Cys Leu Cys Gly Pro Thr Met Asn 
        275                 280                 285             


Val Asn Asn Pro Ser Tyr Gly Glu Ser Val Tyr Gly Pro Ser Ser Pro 
    290                 295                 300                 


Arg Val Pro Val Ile Phe Val Val Asn Asn Gln Glu Glu Leu Glu Arg 
305                 310                 315                 320 


Leu Asn Thr Gln Asn Ala Ile Ala Phe Arg Arg Asp Gln Arg Ser Leu 
                325                 330                 335     


Tyr Phe Lys Asp Ser Leu Gly Trp Leu Pro Ile Gln Leu Thr Pro Phe 
            340                 345                 350         


Tyr Pro Val Asp Tyr Thr Ala Asp Gln His Gly Thr Cys Gly Asp Gly 
        355                 360                 365             


Leu Leu Gln Pro Gly Glu Glu Cys Asp Asp Gly Asn Ser Asp Val Gly 
    370                 375                 380                 


Asp Asp Cys Ile Arg Cys His Arg Ala Tyr Cys Gly Asp Gly His Arg 
385                 390                 395                 400 


His Glu Gly Val Glu Asp Cys Asp Gly Ser Asp Phe Gly Tyr Leu Thr 
                405                 410                 415     


Cys Glu Thr Tyr Leu Pro Gly Ser Tyr Gly Asp Leu Gln Cys Thr Gln 
            420                 425                 430         


Tyr Cys Tyr Ile Asp Ser Thr Pro Cys Arg Tyr Phe Thr 
        435                 440                 445 


<210>  3384
<211>  421
<212>  PRT
<213>  Homo Sapiens

<400>  3384

Met Val Val Leu Asn Pro Met Thr Leu Gly Ile Tyr Leu Gln Leu Phe 
1               5                   10                  15      


Phe Leu Ser Ile Val Ser Gln Pro Thr Phe Ile Asn Ser Val Leu Pro 
            20                  25                  30          


Ile Ser Ala Ala Leu Pro Ser Leu Asp Gln Lys Lys Arg Gly Gly His 
        35                  40                  45              


Lys Ala Cys Cys Leu Leu Thr Pro Pro Pro Pro Pro Leu Phe Pro Pro 
    50                  55                  60                  


Pro Phe Phe Arg Gly Gly Arg Ser Pro Gly Pro Pro Gly Leu Pro Gly 
65                  70                  75                  80  


Lys Thr Gly Pro Lys Gly Glu Lys Gly Glu Leu Gly Arg Pro Gly Arg 
                85                  90                  95      


Lys Gly Arg Pro Gly Pro Pro Gly Val Pro Gly Met Pro Gly Pro Ile 
            100                 105                 110         


Gly Trp Pro Gly Pro Glu Gly Pro Arg Gly Glu Lys Gly Asp Leu Gly 
        115                 120                 125             


Met Met Gly Leu Pro Gly Ser Arg Gly Pro Met Gly Ser Lys Gly Tyr 
    130                 135                 140                 


Pro Gly Ser Arg Gly Glu Lys Gly Ser Arg Gly Glu Lys Gly Asp Leu 
145                 150                 155                 160 


Gly Pro Lys Gly Glu Lys Gly Phe Pro Gly Phe Pro Gly Met Leu Gly 
                165                 170                 175     


Gln Lys Gly Glu Met Gly Pro Lys Gly Glu Pro Gly Ile Ala Gly His 
            180                 185                 190         


Arg Gly Pro Thr Gly Arg Pro Gly Lys Arg Gly Lys Gln Gly Gln Lys 
        195                 200                 205             


Gly Asp Ser Gly Val Met Gly Pro Pro Gly Lys Pro Gly Pro Ser Gly 
    210                 215                 220                 


Gln Pro Gly Arg Pro Gly Pro Pro Gly Pro Pro Pro Ala Gly Gln Leu 
225                 230                 235                 240 


Ile Met Gly Pro Lys Gly Glu Arg Gly Phe Pro Gly Pro Pro Gly Arg 
                245                 250                 255     


Cys Leu Cys Gly Pro Thr Met Asn Val Asn Asn Pro Ser Tyr Gly Glu 
            260                 265                 270         


Ser Val Tyr Gly Pro Ser Ser Pro Arg Val Pro Val Ile Phe Val Val 
        275                 280                 285             


Asn Asn Gln Glu Glu Leu Glu Arg Leu Asn Thr Gln Asn Ala Ile Ala 
    290                 295                 300                 


Phe Arg Arg Asp Gln Arg Ser Leu Tyr Phe Lys Asp Ser Leu Gly Trp 
305                 310                 315                 320 


Leu Pro Ile Gln Leu Thr Pro Phe Tyr Pro Val Asp Tyr Thr Ala Asp 
                325                 330                 335     


Gln His Gly Thr Cys Gly Asp Gly Leu Leu Gln Pro Gly Glu Glu Cys 
            340                 345                 350         


Asp Asp Gly Asn Ser Asp Val Gly Asp Asp Cys Ile Arg Cys His Arg 
        355                 360                 365             


Ala Tyr Cys Gly Asp Gly His Arg His Glu Gly Val Glu Asp Cys Asp 
    370                 375                 380                 


Gly Ser Asp Phe Gly Tyr Leu Thr Cys Glu Thr Tyr Leu Pro Gly Ser 
385                 390                 395                 400 


Tyr Gly Asp Leu Gln Cys Thr Gln Tyr Cys Tyr Ile Asp Ser Thr Pro 
                405                 410                 415     


Cys Arg Tyr Phe Thr 
            420     


<210>  3385
<211>  455
<212>  PRT
<213>  Homo Sapiens

<400>  3385

Met Val Val Leu Asn Pro Met Thr Leu Gly Ile Tyr Leu Gln Leu Phe 
1               5                   10                  15      


Phe Leu Ser Ile Val Ser Gln Pro Thr Phe Ile Asn Ser Val Leu Pro 
            20                  25                  30          


Ile Ser Ala Ala Leu Pro Ser Leu Asp Gln Lys Lys Arg Gly Gly His 
        35                  40                  45              


Lys Ala Cys Cys Leu Leu Thr Pro Pro Pro Pro Pro Leu Phe Pro Pro 
    50                  55                  60                  


Pro Phe Phe Arg Gly Gly Arg Ser Pro Leu Leu Ser Pro Asp Met Lys 
65                  70                  75                  80  


Asn Leu Met Leu Glu Leu Glu Thr Ser Gln Ser Pro Cys Met Gln Gly 
                85                  90                  95      


Ser Leu Gly Ser Pro Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly Leu 
            100                 105                 110         


Pro Gly Lys Thr Gly Pro Lys Gly Glu Lys Gly Glu Leu Gly Arg Pro 
        115                 120                 125             


Gly Arg Lys Gly Arg Pro Gly Pro Pro Gly Val Pro Gly Met Pro Gly 
    130                 135                 140                 


Pro Ile Gly Trp Pro Gly Pro Glu Gly Pro Arg Gly Glu Lys Gly Asp 
145                 150                 155                 160 


Leu Gly Met Met Gly Leu Pro Gly Ser Arg Gly Pro Met Gly Ser Lys 
                165                 170                 175     


Gly Tyr Pro Gly Ser Arg Gly Glu Lys Gly Ser Arg Gly Glu Lys Gly 
            180                 185                 190         


Asp Leu Gly Pro Lys Gly Glu Lys Gly Phe Pro Gly Phe Pro Gly Met 
        195                 200                 205             


Leu Gly Gln Lys Gly Glu Met Gly Pro Lys Gly Glu Pro Gly Ile Ala 
    210                 215                 220                 


Gly His Arg Gly Pro Thr Gly Arg Pro Gly Lys Arg Gly Lys Gln Gly 
225                 230                 235                 240 


Gln Lys Gly Asp Ser Gly Val Met Gly Pro Pro Gly Lys Pro Gly Pro 
                245                 250                 255     


Ser Gly Gln Pro Gly Arg Pro Gly Pro Pro Gly Pro Pro Pro Ala Gly 
            260                 265                 270         


Gln Leu Ile Met Gly Pro Lys Gly Glu Arg Gly Phe Pro Gly Pro Pro 
        275                 280                 285             


Gly Arg Cys Leu Cys Gly Pro Thr Met Asn Val Asn Asn Pro Ser Tyr 
    290                 295                 300                 


Gly Glu Ser Val Tyr Gly Pro Ser Ser Pro Arg Val Pro Val Ile Phe 
305                 310                 315                 320 


Val Val Asn Asn Gln Glu Glu Leu Glu Arg Leu Asn Thr Gln Asn Ala 
                325                 330                 335     


Ile Ala Phe Arg Arg Asp Gln Arg Ser Leu Tyr Phe Lys Asp Ser Leu 
            340                 345                 350         


Gly Trp Leu Pro Ile Gln Leu Thr Pro Phe Tyr Pro Val Asp Tyr Thr 
        355                 360                 365             


Ala Asp Gln His Gly Thr Cys Gly Asp Gly Leu Leu Gln Pro Gly Glu 
    370                 375                 380                 


Glu Cys Asp Asp Gly Asn Ser Asp Val Gly Asp Asp Cys Ile Arg Cys 
385                 390                 395                 400 


His Arg Ala Tyr Cys Gly Asp Gly His Arg His Glu Gly Val Glu Asp 
                405                 410                 415     


Cys Asp Gly Ser Asp Phe Gly Tyr Leu Thr Cys Glu Thr Tyr Leu Pro 
            420                 425                 430         


Gly Ser Tyr Gly Asp Leu Gln Cys Thr Gln Tyr Cys Tyr Ile Asp Ser 
        435                 440                 445             


Thr Pro Cys Arg Tyr Phe Thr 
    450                 455 


<210>  3386
<211>  456
<212>  PRT
<213>  Homo Sapiens

<400>  3386

Met Val Val Leu Asn Pro Met Thr Leu Gly Ile Tyr Leu Gln Leu Phe 
1               5                   10                  15      


Phe Leu Ser Ile Val Ser Gln Pro Thr Phe Ile Asn Ser Val Leu Pro 
            20                  25                  30          


Ile Ser Ala Ala Leu Pro Ser Leu Asp Gln Lys Lys Arg Gly Gly His 
        35                  40                  45              


Lys Ala Cys Cys Leu Leu Thr Pro Pro Pro Pro Pro Leu Phe Pro Pro 
    50                  55                  60                  


Pro Phe Phe Arg Gly Gly Arg Ser Pro Leu Leu Ser Pro Asp Met Lys 
65                  70                  75                  80  


Asn Leu Met Leu Glu Leu Glu Thr Ser Gln Ser Pro Cys Met Gln Gly 
                85                  90                  95      


Ser Leu Gly Ser Pro Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly Leu 
            100                 105                 110         


Pro Gly Lys Thr Gly Pro Lys Gly Glu Lys Gly Glu Leu Gly Arg Pro 
        115                 120                 125             


Gly Arg Lys Gly Arg Pro Gly Pro Pro Gly Val Pro Gly Met Pro Gly 
    130                 135                 140                 


Pro Ile Gly Trp Pro Gly Pro Glu Gly Pro Arg Gly Glu Lys Gly Asp 
145                 150                 155                 160 


Leu Gly Met Met Gly Leu Pro Gly Ser Arg Gly Pro Met Gly Ser Lys 
                165                 170                 175     


Gly Tyr Pro Gly Ser Arg Gly Glu Lys Gly Ser Arg Gly Glu Lys Gly 
            180                 185                 190         


Asp Leu Gly Pro Lys Gly Glu Lys Gly Phe Pro Gly Phe Pro Gly Met 
        195                 200                 205             


Leu Gly Gln Lys Gly Glu Met Gly Pro Lys Gly Glu Pro Gly Ile Ala 
    210                 215                 220                 


Gly His Arg Gly Pro Thr Gly Arg Pro Gly Lys Arg Gly Lys Gln Gly 
225                 230                 235                 240 


Gln Lys Gly Asp Ser Gly Val Met Gly Pro Pro Gly Lys Pro Gly Pro 
                245                 250                 255     


Ser Gly Gln Pro Gly Arg Pro Gly Pro Pro Gly Pro Pro Pro Ala Gly 
            260                 265                 270         


Gln Leu Ile Met Gly Pro Lys Gly Glu Arg Gly Phe Pro Gly Pro Pro 
        275                 280                 285             


Gly Arg Cys Leu Cys Gly Pro Thr Met Asn Val Asn Asn Pro Ser Tyr 
    290                 295                 300                 


Gly Glu Ser Val Tyr Gly Pro Ser Ser Pro Arg Val Pro Val Ile Phe 
305                 310                 315                 320 


Val Val Asn Asn Gln Glu Glu Leu Glu Arg Leu Asn Thr Gln Asn Ala 
                325                 330                 335     


Ile Ala Phe Arg Arg Asp Gln Arg Ser Leu Tyr Phe Lys Asp Ser Leu 
            340                 345                 350         


Gly Trp Leu Pro Ile Gln Leu Thr Pro Phe Tyr Pro Val Asp Tyr Thr 
        355                 360                 365             


Ala Asp Gln His Gly Thr Cys Gly Asp Gly Leu Leu Gln Pro Gly Glu 
    370                 375                 380                 


Glu Cys Asp Asp Gly Asn Ser Asp Val Gly Asp Asp Cys Ile Arg Asp 
385                 390                 395                 400 


Cys His Arg Ala Tyr Cys Gly Asp Gly His Arg His Glu Gly Val Glu 
                405                 410                 415     


Asp Cys Asp Gly Ser Asp Phe Gly Tyr Leu Thr Cys Glu Thr Tyr Leu 
            420                 425                 430         


Pro Gly Ser Tyr Gly Asp Leu Gln Cys Thr Gln Tyr Cys Tyr Ile Asp 
        435                 440                 445             


Ser Thr Pro Cys Arg Tyr Phe Thr 
    450                 455     


<210>  3387
<211>  724
<212>  PRT
<213>  Homo Sapiens

<400>  3387

Met Leu Arg Glu Leu Gln Glu Thr Asn Ala Ala Leu Gln Asp Val Arg 
1               5                   10                  15      


Glu Leu Leu Arg Gln Gln Val Arg Glu Ile Thr Phe Leu Lys Asn Thr 
            20                  25                  30          


Val Met Glu Cys Asp Ala Cys Gly Met Gln Gln Ser Val Arg Thr Gly 
        35                  40                  45              


Leu Pro Ser Val Arg Pro Leu Leu His Cys Ala Pro Gly Phe Cys Phe 
    50                  55                  60                  


Pro Gly Val Ala Cys Ile Gln Thr Glu Ser Gly Ala Arg Cys Gly Pro 
65                  70                  75                  80  


Cys Pro Ala Gly Phe Thr Gly Asn Gly Ser His Cys Thr Asp Val Asn 
                85                  90                  95      


Glu Cys Asn Ala His Pro Cys Phe Pro Arg Val Arg Cys Ile Asn Thr 
            100                 105                 110         


Ser Pro Gly Phe Arg Cys Glu Ala Cys Pro Pro Gly Tyr Ser Gly Pro 
        115                 120                 125             


Thr His Gln Gly Val Gly Leu Ala Phe Ala Lys Ala Asn Lys Gln Val 
    130                 135                 140                 


Cys Thr Asp Ile Asn Glu Cys Glu Thr Gly Gln His Asn Cys Val Pro 
145                 150                 155                 160 


Asn Ser Val Cys Ile Asn Thr Arg Gly Ser Phe Gln Cys Gly Pro Cys 
                165                 170                 175     


Gln Pro Gly Phe Val Gly Asp Gln Ala Ser Gly Cys Gln Arg Arg Ala 
            180                 185                 190         


Gln Arg Phe Cys Pro Asp Gly Ser Pro Ser Glu Cys His Glu His Ala 
        195                 200                 205             


Asp Cys Val Leu Glu Arg Asp Gly Ser Arg Ser Cys Val Cys Ala Val 
    210                 215                 220                 


Gly Trp Ala Gly Asn Gly Ile Leu Cys Gly Arg Asp Thr Asp Leu Asp 
225                 230                 235                 240 


Gly Phe Pro Asp Glu Lys Leu Arg Cys Pro Glu Arg Gln Cys Arg Lys 
                245                 250                 255     


Asp Asn Cys Val Thr Val Pro Asn Ser Gly Gln Glu Asp Val Asp Arg 
            260                 265                 270         


Asp Gly Ile Gly Asp Ala Cys Asp Pro Asp Ala Asp Gly Asp Gly Val 
        275                 280                 285             


Pro Asn Glu Lys Asp Asn Cys Pro Leu Val Arg Asn Pro Asp Gln Arg 
    290                 295                 300                 


Asn Thr Asp Glu Asp Lys Trp Gly Asp Ala Cys Asp Asn Cys Arg Ser 
305                 310                 315                 320 


Gln Lys Asn Asp Asp Gln Lys Asp Thr Asp Gln Asp Gly Arg Gly Asp 
                325                 330                 335     


Ala Cys Asp Asp Asp Ile Asp Gly Asp Arg Ile Arg Asn Gln Ala Asp 
            340                 345                 350         


Asn Cys Pro Arg Val Pro Asn Ser Asp Gln Lys Asp Ser Asp Gly Asp 
        355                 360                 365             


Gly Ile Gly Asp Ala Cys Asp Asn Cys Pro Gln Lys Ser Asn Pro Asp 
    370                 375                 380                 


Gln Ala Asp Val Asp His Asp Phe Val Gly Asp Ala Cys Asp Ser Asp 
385                 390                 395                 400 


Gln Asp Gln Asp Gly Asp Gly His Gln Asp Ser Arg Asp Asn Cys Pro 
                405                 410                 415     


Thr Val Pro Asn Ser Ala Gln Glu Asp Ser Asp His Asp Gly Gln Gly 
            420                 425                 430         


Asp Ala Cys Asp Asp Asp Asp Asp Asn Asp Gly Val Pro Asp Ser Arg 
        435                 440                 445             


Asp Asn Cys Arg Leu Val Pro Asn Pro Gly Gln Glu Asp Ala Asp Arg 
    450                 455                 460                 


Asp Gly Val Gly Asp Val Cys Gln Asp Asp Phe Asp Ala Asp Lys Val 
465                 470                 475                 480 


Val Asp Lys Ile Asp Val Cys Pro Glu Asn Ala Glu Val Thr Leu Thr 
                485                 490                 495     


Asp Phe Arg Ala Phe Gln Thr Val Val Leu Asp Pro Glu Gly Asp Ala 
            500                 505                 510         


Gln Ile Asp Pro Asn Trp Val Val Leu Asn Gln Gly Arg Glu Ile Val 
        515                 520                 525             


Gln Thr Met Asn Ser Asp Pro Gly Leu Ala Val Gly Tyr Thr Ala Phe 
    530                 535                 540                 


Asn Gly Val Asp Phe Glu Gly Thr Phe His Val Asn Thr Val Thr Asp 
545                 550                 555                 560 


Asp Asp Tyr Ala Gly Phe Ile Phe Gly Tyr Gln Asp Ser Ser Ser Phe 
                565                 570                 575     


Tyr Val Val Met Trp Lys Gln Met Glu Gln Thr Tyr Trp Gln Ala Asn 
            580                 585                 590         


Pro Phe Arg Ala Val Ala Glu Pro Gly Ile Gln Leu Lys Ala Val Lys 
        595                 600                 605             


Ser Ser Thr Gly Pro Gly Glu Gln Leu Arg Asn Ala Leu Trp His Thr 
    610                 615                 620                 


Gly Asp Thr Glu Ser Gln Val Arg Leu Leu Trp Lys Asp Pro Arg Asn 
625                 630                 635                 640 


Val Gly Trp Lys Asp Lys Lys Ser Tyr Arg Trp Phe Leu Gln His Arg 
                645                 650                 655     


Pro Gln Val Gly Tyr Ile Arg Val Arg Phe Tyr Glu Gly Pro Glu Leu 
            660                 665                 670         


Val Ala Asp Ser Asn Val Val Leu Asp Thr Thr Met Arg Gly Gly Arg 
        675                 680                 685             


Leu Gly Val Phe Cys Phe Ser Gln Glu Asn Ile Ile Trp Ala Asn Leu 
    690                 695                 700                 


Arg Tyr Arg Cys Asn Asp Thr Ile Pro Glu Asp Tyr Glu Thr His Gln 
705                 710                 715                 720 


Leu Arg Gln Ala 
                


<210>  3388
<211>  704
<212>  PRT
<213>  Homo Sapiens

<400>  3388

Met Val Pro Asp Thr Ala Cys Val Leu Leu Leu Thr Leu Ala Ala Leu 
1               5                   10                  15      


Gly Ala Ser Gly Gln Gly Gln Ser Pro Leu Gly Ser Asp Leu Gly Pro 
            20                  25                  30          


Gln Met Leu Arg Glu Leu Gln Glu Thr Asn Ala Ala Leu Gln Asp Val 
        35                  40                  45              


Arg Glu Leu Leu Arg Gln Gln Val Arg Glu Ile Thr Phe Leu Lys Asn 
    50                  55                  60                  


Thr Val Met Glu Cys Asp Ala Cys Gly Met Gln Gln Ser Val Arg Thr 
65                  70                  75                  80  


Gly Leu Pro Ser Val Arg Pro Leu Leu His Cys Ala Pro Gly Phe Cys 
                85                  90                  95      


Phe Pro Gly Val Ala Cys Ile Gln Thr Glu Ser Gly Ala Arg Cys Gly 
            100                 105                 110         


Pro Cys Pro Ala Gly Phe Thr Gly Asn Gly Ser His Cys Thr Asp Val 
        115                 120                 125             


Asn Glu Cys Glu Thr Gly Gln His Asn Cys Val Pro Asn Ser Val Cys 
    130                 135                 140                 


Ile Asn Thr Arg Gly Ser Phe Gln Cys Gly Pro Cys Gln Pro Gly Phe 
145                 150                 155                 160 


Val Gly Asp Gln Ala Ser Gly Cys Gln Arg Arg Ala Gln Arg Phe Cys 
                165                 170                 175     


Pro Asp Gly Ser Pro Ser Glu Cys His Glu His Ala Asp Cys Val Leu 
            180                 185                 190         


Glu Arg Asp Gly Ser Arg Ser Cys Val Cys Ala Val Gly Trp Ala Gly 
        195                 200                 205             


Asn Gly Ile Leu Cys Gly Arg Asp Thr Asp Leu Asp Gly Phe Pro Asp 
    210                 215                 220                 


Glu Lys Leu Arg Cys Pro Glu Arg Gln Cys Arg Lys Asp Asn Cys Val 
225                 230                 235                 240 


Thr Val Pro Asn Ser Gly Gln Glu Asp Val Asp Arg Asp Gly Ile Gly 
                245                 250                 255     


Asp Ala Cys Asp Pro Asp Ala Asp Gly Asp Gly Val Pro Asn Glu Lys 
            260                 265                 270         


Asp Asn Cys Pro Leu Val Arg Asn Pro Asp Gln Arg Asn Thr Asp Glu 
        275                 280                 285             


Asp Lys Trp Gly Asp Ala Cys Asp Asn Cys Arg Ser Gln Lys Asn Asp 
    290                 295                 300                 


Asp Gln Lys Asp Thr Asp Gln Asp Gly Arg Gly Asp Ala Cys Asp Asp 
305                 310                 315                 320 


Asp Ile Asp Gly Asp Arg Ile Arg Asn Gln Ala Asp Asn Cys Pro Arg 
                325                 330                 335     


Val Pro Asn Ser Asp Gln Lys Asp Ser Asp Gly Asp Gly Ile Gly Asp 
            340                 345                 350         


Ala Cys Asp Asn Cys Pro Gln Lys Ser Asn Pro Asp Gln Ala Asp Val 
        355                 360                 365             


Asp His Asp Phe Val Gly Asp Ala Cys Asp Ser Asp Gln Asp Gln Asp 
    370                 375                 380                 


Gly Asp Gly His Gln Asp Ser Arg Asp Asn Cys Pro Thr Val Pro Asn 
385                 390                 395                 400 


Ser Ala Gln Glu Asp Ser Asp His Asp Gly Gln Gly Asp Ala Cys Asp 
                405                 410                 415     


Asp Asp Asp Asp Asn Asp Gly Val Pro Asp Ser Arg Asp Asn Cys Arg 
            420                 425                 430         


Leu Val Pro Asn Pro Gly Gln Glu Asp Ala Asp Arg Asp Gly Val Gly 
        435                 440                 445             


Asp Val Cys Gln Asp Asp Phe Asp Ala Asp Lys Val Val Asp Lys Ile 
    450                 455                 460                 


Asp Val Cys Pro Glu Asn Ala Glu Val Thr Leu Thr Asp Phe Arg Ala 
465                 470                 475                 480 


Phe Gln Thr Val Val Leu Asp Pro Glu Gly Asp Ala Gln Ile Asp Pro 
                485                 490                 495     


Asn Trp Val Val Leu Asn Gln Gly Arg Glu Ile Val Gln Thr Met Asn 
            500                 505                 510         


Ser Asp Pro Gly Leu Ala Val Gly Tyr Thr Ala Phe Asn Gly Val Asp 
        515                 520                 525             


Phe Glu Gly Thr Phe His Val Asn Thr Val Thr Asp Asp Asp Tyr Ala 
    530                 535                 540                 


Gly Phe Ile Phe Gly Tyr Gln Asp Ser Ser Ser Phe Tyr Val Val Met 
545                 550                 555                 560 


Trp Lys Gln Met Glu Gln Thr Tyr Trp Gln Ala Asn Pro Phe Arg Ala 
                565                 570                 575     


Val Ala Glu Pro Gly Ile Gln Leu Lys Ala Val Lys Ser Ser Thr Gly 
            580                 585                 590         


Pro Gly Glu Gln Leu Arg Asn Ala Leu Trp His Thr Gly Asp Thr Glu 
        595                 600                 605             


Ser Gln Val Arg Leu Leu Trp Lys Asp Pro Arg Asn Val Gly Trp Lys 
    610                 615                 620                 


Asp Lys Lys Ser Tyr Arg Trp Phe Leu Gln His Arg Pro Gln Val Gly 
625                 630                 635                 640 


Tyr Ile Arg Val Arg Phe Tyr Glu Gly Pro Glu Leu Val Ala Asp Ser 
                645                 650                 655     


Asn Val Val Leu Asp Thr Thr Met Arg Gly Gly Arg Leu Gly Val Phe 
            660                 665                 670         


Cys Phe Ser Gln Glu Asn Ile Ile Trp Ala Asn Leu Arg Tyr Arg Cys 
        675                 680                 685             


Asn Asp Thr Ile Pro Glu Asp Tyr Glu Thr His Gln Leu Arg Gln Ala 
    690                 695                 700                 


<210>  3389
<211>  757
<212>  PRT
<213>  Homo Sapiens

<400>  3389

Met Val Pro Asp Thr Ala Cys Val Leu Leu Leu Thr Leu Ala Ala Leu 
1               5                   10                  15      


Gly Ala Ser Gly Gln Gly Gln Ser Pro Leu Gly Ser Asp Leu Gly Pro 
            20                  25                  30          


Gln Met Leu Arg Glu Leu Gln Glu Thr Asn Ala Ala Leu Gln Asp Val 
        35                  40                  45              


Arg Glu Leu Leu Arg Gln Gln Val Arg Glu Ile Thr Phe Leu Lys Asn 
    50                  55                  60                  


Thr Val Met Glu Cys Asp Ala Cys Gly Met Gln Gln Ser Val Arg Thr 
65                  70                  75                  80  


Gly Leu Pro Ser Val Arg Pro Leu Leu His Cys Ala Pro Gly Phe Cys 
                85                  90                  95      


Phe Pro Gly Val Ala Cys Ile Gln Thr Glu Ser Gly Ala Arg Cys Gly 
            100                 105                 110         


Pro Cys Pro Ala Gly Phe Thr Gly Asn Gly Ser His Cys Thr Asp Val 
        115                 120                 125             


Asn Glu Cys Asn Ala His Pro Cys Phe Pro Arg Val Arg Cys Ile Asn 
    130                 135                 140                 


Thr Ser Pro Gly Phe Arg Cys Glu Ala Cys Pro Pro Gly Tyr Ser Gly 
145                 150                 155                 160 


Pro Thr His Gln Gly Val Gly Leu Ala Phe Ala Lys Ala Asn Lys Gln 
                165                 170                 175     


Val Cys Thr Asp Ile Asn Glu Cys Glu Thr Gly Gln His Asn Cys Val 
            180                 185                 190         


Pro Asn Ser Val Cys Ile Asn Thr Arg Gly Ser Phe Gln Cys Gly Pro 
        195                 200                 205             


Cys Gln Pro Gly Phe Val Gly Asp Gln Ala Ser Gly Cys Gln Arg Arg 
    210                 215                 220                 


Ala Gln Arg Phe Cys Pro Asp Gly Ser Pro Ser Glu Cys His Glu His 
225                 230                 235                 240 


Ala Asp Cys Val Leu Glu Arg Asp Gly Ser Arg Ser Cys Val Cys Ala 
                245                 250                 255     


Val Gly Trp Ala Gly Asn Gly Ile Leu Cys Gly Arg Asp Thr Asp Leu 
            260                 265                 270         


Asp Gly Phe Pro Asp Glu Lys Leu Arg Cys Pro Glu Arg Gln Cys Arg 
        275                 280                 285             


Lys Asp Asn Cys Val Thr Val Pro Asn Ser Gly Gln Glu Asp Val Asp 
    290                 295                 300                 


Arg Asp Gly Ile Gly Asp Ala Cys Asp Pro Asp Ala Asp Gly Asp Gly 
305                 310                 315                 320 


Val Pro Asn Glu Lys Asp Asn Cys Pro Leu Val Arg Asn Pro Asp Gln 
                325                 330                 335     


Arg Asn Thr Asp Glu Asp Lys Trp Gly Asp Ala Cys Asp Asn Cys Arg 
            340                 345                 350         


Ser Gln Lys Asn Asp Asp Gln Lys Asp Thr Asp Gln Asp Gly Arg Gly 
        355                 360                 365             


Asp Ala Cys Asp Asp Asp Ile Asp Gly Asp Arg Ile Arg Asn Gln Ala 
    370                 375                 380                 


Asp Asn Cys Pro Arg Val Pro Asn Ser Asp Gln Lys Asp Ser Asp Gly 
385                 390                 395                 400 


Asp Gly Ile Gly Asp Ala Cys Asp Asn Cys Pro Gln Lys Ser Asn Pro 
                405                 410                 415     


Asp Gln Ala Asp Val Asp His Asp Phe Val Gly Asp Ala Cys Asp Ser 
            420                 425                 430         


Asp Gln Asp Gln Asp Gly Asp Gly His Gln Asp Ser Arg Asp Asn Cys 
        435                 440                 445             


Pro Thr Val Pro Asn Ser Ala Gln Glu Asp Ser Asp His Asp Gly Gln 
    450                 455                 460                 


Gly Asp Ala Cys Asp Asp Asp Asp Asp Asn Asp Gly Val Pro Asp Ser 
465                 470                 475                 480 


Arg Asp Asn Cys Arg Leu Val Pro Asn Pro Gly Gln Glu Asp Ala Asp 
                485                 490                 495     


Arg Asp Gly Val Gly Asp Val Cys Gln Asp Asp Phe Asp Ala Asp Lys 
            500                 505                 510         


Val Val Asp Lys Ile Asp Val Cys Pro Glu Asn Ala Glu Val Thr Leu 
        515                 520                 525             


Thr Asp Phe Arg Ala Phe Gln Thr Val Val Leu Asp Pro Glu Gly Asp 
    530                 535                 540                 


Ala Gln Ile Asp Pro Asn Trp Val Val Leu Asn Gln Gly Arg Glu Ile 
545                 550                 555                 560 


Val Gln Thr Met Asn Ser Asp Pro Gly Leu Ala Val Gly Tyr Thr Ala 
                565                 570                 575     


Phe Asn Gly Val Asp Phe Glu Gly Thr Phe His Val Asn Thr Val Thr 
            580                 585                 590         


Asp Asp Asp Tyr Ala Gly Phe Ile Phe Gly Tyr Gln Asp Ser Ser Ser 
        595                 600                 605             


Phe Tyr Val Val Met Trp Lys Gln Met Glu Gln Thr Tyr Trp Gln Ala 
    610                 615                 620                 


Asn Pro Phe Arg Ala Val Ala Glu Pro Gly Ile Gln Leu Lys Ala Val 
625                 630                 635                 640 


Lys Ser Ser Thr Gly Pro Gly Glu Gln Leu Arg Asn Ala Leu Trp His 
                645                 650                 655     


Thr Gly Asp Thr Glu Ser Gln Val Arg Leu Leu Trp Lys Asp Pro Arg 
            660                 665                 670         


Asn Val Gly Trp Lys Asp Lys Lys Ser Tyr Arg Trp Phe Leu Gln His 
        675                 680                 685             


Arg Pro Gln Val Gly Tyr Ile Arg Val Arg Phe Tyr Glu Gly Pro Glu 
    690                 695                 700                 


Leu Val Ala Asp Ser Asn Val Val Leu Asp Thr Thr Met Arg Gly Gly 
705                 710                 715                 720 


Arg Leu Gly Val Phe Cys Phe Ser Gln Glu Asn Ile Ile Trp Ala Asn 
                725                 730                 735     


Leu Arg Tyr Arg Cys Asn Asp Thr Ile Pro Glu Asp Tyr Glu Thr His 
            740                 745                 750         


Gln Leu Arg Gln Ala 
        755         


<210>  3390
<211>  123
<212>  PRT
<213>  Homo Sapiens

<400>  3390

Leu Gly Trp Tyr Thr Thr Gly Gly Pro Pro Asp Pro Ser Asp Ile His 
1               5                   10                  15      


Val His Lys Gln Val Cys Glu Ile Ile Glu Ser Pro Leu Phe Leu Lys 
            20                  25                  30          


Leu Asn Pro Met Thr Lys His Thr Asp Leu Pro Val Ser Val Phe Glu 
        35                  40                  45              


Ser Val Ile Asp Ile Ile Asn Gly Glu Ala Thr Met Leu Phe Ala Glu 
    50                  55                  60                  


Leu Thr Tyr Thr Leu Ala Thr Glu Glu Ala Glu Arg Ile Gly Val Asp 
65                  70                  75                  80  


His Val Ala Arg Met Thr Ala Thr Gly Ser Gly Glu Asn Ser Thr Val 
                85                  90                  95      


Ala Glu His Leu Ile Ala Gln His Ser Ala Ile Lys Met Leu His Ser 
            100                 105                 110         


Arg Val Lys Leu Ile Leu Glu Arg Gly Pro Leu 
        115                 120             


<210>  3391
<211>  326
<212>  PRT
<213>  Homo Sapiens

<400>  3391

Met Ala Ala Ala Ala Ala Ala Ala Ala Ala Thr Asn Gly Thr Gly Gly 
1               5                   10                  15      


Ser Ser Gly Met Glu Val Asp Ala Ala Val Pro Ser Val Met Ala Cys 
            20                  25                  30          


Gly Val Thr Gly Ser Val Ser Val Ala Leu His Pro Leu Val Ile Leu 
        35                  40                  45              


Asn Ile Ser Asp His Trp Ile Arg Met Arg Ser Gln Glu Gly Arg Pro 
    50                  55                  60                  


Val Gln Val Ile Gly Ala Leu Ile Gly Lys Gln Glu Gly Arg Asn Ile 
65                  70                  75                  80  


Glu Val Met Asn Ser Phe Glu Leu Leu Ser His Thr Val Glu Glu Lys 
                85                  90                  95      


Ile Ile Ile Asp Lys Glu Tyr Tyr Tyr Thr Lys Glu Glu Gln Phe Lys 
            100                 105                 110         


Gln Val Phe Lys Glu Leu Glu Phe Leu Gly Trp Tyr Thr Thr Gly Gly 
        115                 120                 125             


Pro Pro Asp Pro Ser Asp Ile His Val His Lys Gln Val Cys Glu Ile 
    130                 135                 140                 


Ile Glu Ser Pro Leu Phe Leu Lys Leu Asn Pro Met Thr Lys His Thr 
145                 150                 155                 160 


Asp Leu Pro Val Ser Val Phe Glu Ser Val Ile Asp Ile Ile Asn Gly 
                165                 170                 175     


Glu Ala Thr Met Leu Phe Ala Glu Leu Thr Tyr Thr Leu Ala Thr Glu 
            180                 185                 190         


Glu Ala Glu Arg Ile Gly Val Asp His Val Ala Arg Met Thr Ala Thr 
        195                 200                 205             


Gly Ser Gly Glu Asn Ser Thr Val Ala Glu His Leu Ile Ala Gln His 
    210                 215                 220                 


Ser Ala Ile Lys Met Leu His Ser Arg Val Lys Leu Ile Leu Glu Tyr 
225                 230                 235                 240 


Val Lys Ala Ser Glu Ala Gly Glu Val Pro Phe Asn His Glu Ile Leu 
                245                 250                 255     


Arg Glu Ala Tyr Ala Leu Cys His Cys Leu Pro Val Leu Ser Thr Asp 
            260                 265                 270         


Lys Phe Lys Thr Asp Phe Tyr Asp Gln Cys Asn Asp Val Gly Leu Met 
        275                 280                 285             


Ala Tyr Leu Gly Thr Ile Thr Lys Thr Cys Asn Thr Met Asn Gln Phe 
    290                 295                 300                 


Val Asn Lys Phe Asn Val Leu Tyr Asp Arg Gln Gly Ile Gly Arg Arg 
305                 310                 315                 320 


Met Arg Gly Leu Phe Phe 
                325     


<210>  3392
<211>  327
<212>  PRT
<213>  Homo Sapiens

<400>  3392

Met Ala Ala Ala Ala Ala Ala Ala Ala Ala Thr Asn Gly Thr Gly Gly 
1               5                   10                  15      


Ser Ser Gly Met Glu Val Asp Ala Ala Val Val Pro Ser Val Met Ala 
            20                  25                  30          


Cys Gly Val Thr Gly Ser Val Ser Val Ala Leu His Pro Leu Val Ile 
        35                  40                  45              


Leu Asn Ile Ser Asp His Trp Ile Arg Met Arg Ser Gln Glu Gly Arg 
    50                  55                  60                  


Pro Val Gln Val Ile Gly Ala Leu Ile Gly Lys Gln Glu Gly Arg Asn 
65                  70                  75                  80  


Ile Glu Val Met Asn Ser Phe Glu Leu Leu Ser His Thr Val Glu Glu 
                85                  90                  95      


Lys Ile Ile Ile Asp Lys Glu Tyr Tyr Tyr Thr Lys Glu Glu Gln Phe 
            100                 105                 110         


Lys Gln Val Phe Lys Glu Leu Glu Phe Leu Gly Trp Tyr Thr Thr Gly 
        115                 120                 125             


Gly Pro Pro Asp Pro Ser Asp Ile His Val His Lys Gln Val Cys Glu 
    130                 135                 140                 


Ile Ile Glu Ser Pro Leu Phe Leu Lys Leu Asn Pro Met Thr Lys His 
145                 150                 155                 160 


Thr Asp Leu Pro Val Ser Val Phe Glu Ser Val Ile Asp Ile Ile Asn 
                165                 170                 175     


Gly Glu Ala Thr Met Leu Phe Ala Glu Leu Thr Tyr Thr Leu Ala Thr 
            180                 185                 190         


Glu Glu Ala Glu Arg Ile Gly Val Asp His Val Ala Arg Met Thr Ala 
        195                 200                 205             


Thr Gly Ser Gly Glu Asn Ser Thr Val Ala Glu His Leu Ile Ala Gln 
    210                 215                 220                 


His Ser Ala Ile Lys Met Leu His Ser Arg Val Lys Leu Ile Leu Glu 
225                 230                 235                 240 


Tyr Val Lys Ala Ser Glu Ala Gly Glu Val Pro Phe Asn His Glu Ile 
                245                 250                 255     


Leu Arg Glu Ala Tyr Ala Leu Cys His Cys Leu Pro Val Leu Ser Thr 
            260                 265                 270         


Asp Lys Phe Lys Thr Asp Phe Tyr Asp Gln Cys Asn Asp Val Gly Leu 
        275                 280                 285             


Met Ala Tyr Leu Gly Thr Ile Thr Lys Thr Cys Asn Thr Met Asn Gln 
    290                 295                 300                 


Phe Val Asn Lys Phe Asn Val Leu Tyr Asp Arg Gln Gly Ile Gly Arg 
305                 310                 315                 320 


Arg Met Arg Gly Leu Phe Phe 
                325         


<210>  3393
<211>  42
<212>  PRT
<213>  Homo Sapiens

<400>  3393

Met Ala Cys Gly Val Thr Gly Ser Val Ser Val Ala Leu His Pro Leu 
1               5                   10                  15      


Val Ile Leu Asn Ile Ser Asp His Trp Ile Arg Met Arg Ser Gln Glu 
            20                  25                  30          


Gly Arg Pro Val Gln Val Ile Gly Ala Leu 
        35                  40          


<210>  3394
<211>  468
<212>  PRT
<213>  Homo Sapiens

<400>  3394

Met Ala Ala Arg Leu Val Ser Arg Cys Gly Ala Val Arg Ala Ala Pro 
1               5                   10                  15      


His Ser Gly Pro Leu Val Ser Trp Arg Arg Trp Ser Gly Ala Ser Thr 
            20                  25                  30          


Asp Thr Val Tyr Asp Val Val Val Ser Gly Gly Gly Leu Val Gly Ala 
        35                  40                  45              


Ala Met Ala Cys Ala Leu Gly Tyr Asp Ile His Phe His Asp Lys Lys 
    50                  55                  60                  


Ile Leu Leu Leu Glu Ala Gly Pro Lys Lys Val Leu Glu Lys Leu Ser 
65                  70                  75                  80  


Glu Thr Tyr Ser Asn Arg Val Ser Ser Ile Ser Pro Gly Ser Ala Thr 
                85                  90                  95      


Leu Leu Ser Ser Phe Gly Ala Trp Asp His Ile Cys Asn Met Arg Tyr 
            100                 105                 110         


Arg Ala Phe Arg Arg Met Gln Val Trp Asp Ala Cys Ser Glu Ala Leu 
        115                 120                 125             


Ile Met Phe Asp Lys Asp Asn Leu Asp Asp Met Gly Tyr Ile Val Glu 
    130                 135                 140                 


Asn Asp Val Ile Met His Ala Leu Thr Lys Gln Leu Glu Ala Val Ser 
145                 150                 155                 160 


Asp Arg Val Thr Val Leu Tyr Arg Ser Lys Ala Ile Arg Tyr Thr Trp 
                165                 170                 175     


Pro Cys Pro Phe Pro Met Ala Asp Ser Ser Pro Trp Val His Ile Thr 
            180                 185                 190         


Leu Gly Asp Gly Ser Thr Phe Gln Thr Lys Leu Leu Ile Gly Ala Asp 
        195                 200                 205             


Gly His Asn Ser Gly Val Arg Gln Ala Val Gly Ile Gln Asn Val Ser 
    210                 215                 220                 


Trp Asn Tyr Asp Gln Ser Ala Val Val Ala Thr Leu His Leu Ser Glu 
225                 230                 235                 240 


Ala Thr Glu Asn Asn Val Ala Trp Gln Arg Phe Leu Pro Ser Gly Pro 
                245                 250                 255     


Ile Ala Leu Leu Pro Leu Ser Asp Thr Leu Ser Ser Leu Val Trp Ser 
            260                 265                 270         


Thr Ser His Glu His Ala Ala Glu Leu Val Ser Met Asp Glu Glu Lys 
        275                 280                 285             


Phe Val Asp Ala Val Asn Ser Ala Phe Trp Ser Asp Ala Asp His Thr 
    290                 295                 300                 


Asp Phe Ile Asp Thr Ala Gly Ala Met Leu Gln Tyr Ala Val Ser Leu 
305                 310                 315                 320 


Leu Lys Pro Thr Lys Val Ser Ala Arg Gln Leu Pro Pro Ser Val Ala 
                325                 330                 335     


Arg Val Asp Ala Lys Ser Arg Val Leu Phe Pro Leu Gly Leu Gly His 
            340                 345                 350         


Ala Ala Glu Tyr Val Arg Pro Arg Val Ala Leu Ile Gly Asp Ala Ala 
        355                 360                 365             


His Arg Val His Pro Leu Ala Gly Gln Gly Val Asn Met Gly Phe Gly 
    370                 375                 380                 


Asp Ile Ser Ser Leu Ala His His Leu Ser Thr Ala Ala Phe Asn Gly 
385                 390                 395                 400 


Lys Asp Leu Gly Ser Val Ser His Leu Thr Gly Tyr Glu Thr Glu Arg 
                405                 410                 415     


Gln Arg His Asn Thr Ala Leu Leu Ala Ala Thr Asp Leu Leu Lys Arg 
            420                 425                 430         


Leu Tyr Ser Thr Ser Ala Ser Pro Leu Val Leu Leu Arg Thr Trp Gly 
        435                 440                 445             


Leu Gln Ala Thr Asn Ala Val Ser Pro Leu Lys Glu Gln Ile Met Ala 
    450                 455                 460                 


Phe Ala Ser Lys 
465             


<210>  3395
<211>  200
<212>  PRT
<213>  Homo Sapiens

<400>  3395

Met Ala Ala Arg Leu Val Ser Arg Cys Gly Ala Val Arg Ala Ala Pro 
1               5                   10                  15      


His Ser Gly Pro Leu Val Ser Trp Arg Arg Trp Ser Gly Ala Ser Thr 
            20                  25                  30          


Asp Thr Val Tyr Asp Val Val Val Ser Gly Gly Gly Leu Val Gly Ala 
        35                  40                  45              


Ala Met Ala Cys Ala Leu Gly Tyr Asp Ile His Phe His Asp Lys Lys 
    50                  55                  60                  


Ile Leu Leu Leu Glu Ala Gly Pro Lys Lys Val Leu Glu Lys Leu Ser 
65                  70                  75                  80  


Glu Thr Tyr Ser Asn Arg Val Ser Ser Ile Ser Pro Gly Ser Ala Thr 
                85                  90                  95      


Leu Leu Ser Ser Phe Gly Ala Trp Asp His Ile Cys Asn Met Arg Tyr 
            100                 105                 110         


Arg Ala Phe Arg Arg Met Gln Val Trp Asp Ala Cys Ser Glu Ala Leu 
        115                 120                 125             


Ile Met Phe Asp Lys Asp Asn Leu Asp Asp Met Gly Tyr Ile Val Glu 
    130                 135                 140                 


Asn Asp Val Ile Met His Ala Leu Thr Lys Gln Leu Glu Ala Val Ser 
145                 150                 155                 160 


Gly Thr Asp Tyr Gly Leu Cys Lys Gln Met Ser Thr Pro Leu Leu Lys 
                165                 170                 175     


Lys Asp Tyr Val Asp Glu Lys Glu His Pro Ala Gln Asp Pro Ser Tyr 
            180                 185                 190         


Ile Phe Ser Arg Ser Tyr Leu Ile 
        195                 200 


<210>  3396
<211>  111
<212>  PRT
<213>  Homo Sapiens

<400>  3396

Met Ala Ala Arg Leu Val Ser Arg Cys Gly Ala Val Arg Ala Ala Pro 
1               5                   10                  15      


His Ser Gly Pro Leu Val Ser Trp Arg Arg Trp Ser Gly Ala Ser Thr 
            20                  25                  30          


Asp Thr Val Tyr Asp Val Val Val Ser Gly Gly Gly Leu Val Gly Ala 
        35                  40                  45              


Ala Met Ala Cys Ala Leu Gly Tyr Asp Ile His Phe His Asp Lys Lys 
    50                  55                  60                  


Ile Leu Leu Leu Glu Ala Gly Pro Lys Lys Val Leu Glu Lys Leu Ser 
65                  70                  75                  80  


Glu Thr Tyr Ser Asn Arg Val Ser Ser Ile Ser Pro Gly Ser Ala Thr 
                85                  90                  95      


Leu Leu Ser Ser Val Gly Arg Leu Leu Arg Gly Pro Asp Asn Val 
            100                 105                 110     


<210>  3397
<211>  54
<212>  PRT
<213>  Homo Sapiens

<400>  3397

Met Ile Phe Thr Phe Met Thr Arg Lys Ser Cys Cys Ser Lys Gln Val 
1               5                   10                  15      


Gln Arg Lys Tyr Trp Arg Asn Cys Gln Lys Leu Thr Ala Thr Gly Ser 
            20                  25                  30          


Ala Pro Phe Pro Leu Ala Leu Gln Arg Phe Ser Val Val Leu Val Pro 
        35                  40                  45              


Gly Thr Ile Ser Ala Thr 
    50                  


<210>  3398
<211>  262
<212>  PRT
<213>  Homo Sapiens

<400>  3398

Met Ile Phe Thr Phe Met Thr Arg Lys Ser Cys Cys Ser Lys Gln Val 
1               5                   10                  15      


Gln Arg Lys Tyr Trp Arg Asn Cys Gln Lys Leu Thr Ala Thr Gly Ser 
            20                  25                  30          


Ala Pro Phe Pro Leu Ala Leu Gln Arg Phe Ser Val Val Trp Asp Ala 
        35                  40                  45              


Cys Ser Glu Ala Leu Ile Met Phe Asp Lys Asp Asn Leu Asp Asp Met 
    50                  55                  60                  


Gly Tyr Ile Val Glu Asn Asp Val Ile Met His Ala Leu Thr Lys Gln 
65                  70                  75                  80  


Leu Glu Ala Val Ser Asp Arg Val Thr Val Leu Tyr Arg Ser Lys Ala 
                85                  90                  95      


Ile Arg Tyr Thr Trp Pro Cys Pro Phe Pro Met Ala Asp Ser Ser Pro 
            100                 105                 110         


Trp Val His Ile Thr Leu Gly Asp Gly Ser Thr Phe Gln Thr Lys Leu 
        115                 120                 125             


Leu Ile Gly Ala Asp Gly His Asn Ser Gly Val Arg Gln Ala Val Gly 
    130                 135                 140                 


Ile Gln Asn Val Ser Trp Asn Tyr Asp Gln Ser Ala Val Val Ala Thr 
145                 150                 155                 160 


Leu His Leu Ser Glu Ala Thr Glu Asn Asn Val Ala Trp Gln Arg Phe 
                165                 170                 175     


Leu Pro Ser Gly Pro Ile Ala Leu Leu Pro Leu Ser Asp Thr Leu Ser 
            180                 185                 190         


Ser Leu Val Trp Ser Thr Ser His Glu His Ala Ala Glu Leu Val Ser 
        195                 200                 205             


Met Asp Glu Glu Lys Phe Val Asp Ala Val Asn Ser Ala Phe Trp Ser 
    210                 215                 220                 


Asp Ala Asp His Thr Asp Phe Ile Asp Thr Ala Gly Ala Met Leu Gln 
225                 230                 235                 240 


Tyr Ala Val Ser Leu Leu Lys Pro Thr Lys Val Ser Ala Arg Gln Leu 
                245                 250                 255     


Pro Pro Ser Val Ala Arg 
            260         


<210>  3399
<211>  393
<212>  PRT
<213>  Homo Sapiens

<400>  3399

Met Ile Phe Thr Phe Met Thr Arg Lys Ser Cys Cys Ser Lys Gln Val 
1               5                   10                  15      


Gln Arg Lys Tyr Trp Arg Asn Cys Gln Lys Leu Thr Ala Thr Gly Ser 
            20                  25                  30          


Ala Pro Phe Pro Leu Ala Leu Gln Arg Phe Ser Val Val Trp Asp Ala 
        35                  40                  45              


Cys Ser Glu Ala Leu Ile Met Phe Asp Lys Asp Asn Leu Asp Asp Met 
    50                  55                  60                  


Gly Tyr Ile Val Glu Asn Asp Val Ile Met His Ala Leu Thr Lys Gln 
65                  70                  75                  80  


Leu Glu Ala Val Ser Asp Arg Val Thr Val Leu Tyr Arg Ser Lys Ala 
                85                  90                  95      


Ile Arg Tyr Thr Trp Pro Cys Pro Phe Pro Met Ala Asp Ser Ser Pro 
            100                 105                 110         


Trp Val His Ile Thr Leu Gly Asp Gly Ser Thr Phe Gln Thr Lys Leu 
        115                 120                 125             


Leu Ile Gly Ala Asp Gly His Asn Ser Gly Val Arg Gln Ala Val Gly 
    130                 135                 140                 


Ile Gln Asn Val Ser Trp Asn Tyr Asp Gln Ser Ala Val Val Ala Thr 
145                 150                 155                 160 


Leu His Leu Ser Glu Ala Thr Glu Asn Asn Val Ala Trp Gln Arg Phe 
                165                 170                 175     


Leu Pro Ser Gly Pro Ile Ala Leu Leu Pro Leu Ser Asp Thr Leu Ser 
            180                 185                 190         


Ser Leu Val Trp Ser Thr Ser His Glu His Ala Ala Glu Leu Val Ser 
        195                 200                 205             


Met Asp Glu Glu Lys Phe Val Asp Ala Val Asn Ser Ala Phe Trp Ser 
    210                 215                 220                 


Asp Ala Asp His Thr Asp Phe Ile Asp Thr Ala Gly Ala Met Leu Gln 
225                 230                 235                 240 


Tyr Ala Val Ser Leu Leu Lys Pro Thr Lys Val Ser Ala Arg Gln Leu 
                245                 250                 255     


Pro Pro Ser Val Ala Arg Val Asp Ala Lys Ser Arg Val Leu Phe Pro 
            260                 265                 270         


Leu Gly Leu Gly His Ala Ala Glu Tyr Val Arg Pro Arg Val Ala Leu 
        275                 280                 285             


Ile Gly Asp Ala Ala His Arg Val His Pro Leu Ala Gly Gln Gly Val 
    290                 295                 300                 


Asn Met Gly Phe Gly Asp Ile Ser Ser Leu Ala His His Leu Ser Thr 
305                 310                 315                 320 


Ala Ala Phe Asn Gly Lys Asp Leu Gly Ser Val Ser His Leu Thr Gly 
                325                 330                 335     


Tyr Glu Thr Glu Arg Gln Arg His Asn Thr Ala Leu Leu Ala Ala Thr 
            340                 345                 350         


Asp Leu Leu Lys Arg Leu Tyr Ser Thr Ser Ala Ser Pro Leu Val Leu 
        355                 360                 365             


Leu Arg Thr Trp Gly Leu Gln Ala Thr Asn Ala Val Ser Pro Leu Lys 
    370                 375                 380                 


Glu Gln Ile Met Ala Phe Ala Ser Lys 
385                 390             


<210>  3400
<211>  443
<212>  PRT
<213>  Homo Sapiens

<400>  3400

Met Arg Gly Gln Gly Pro Pro Leu Ser Ser Phe Gly Val Trp Leu Ala 
1               5                   10                  15      


Ser Arg Ala Ala Ser Asp Pro Ser Arg Pro Arg Arg Gln Gly Tyr Asp 
            20                  25                  30          


Ile His Phe His Asp Lys Lys Ile Leu Leu Leu Glu Ala Gly Pro Lys 
        35                  40                  45              


Lys Val Leu Glu Lys Leu Ser Glu Thr Tyr Ser Asn Arg Val Ser Ser 
    50                  55                  60                  


Ile Ser Pro Gly Ser Ala Thr Leu Leu Ser Ser Phe Gly Ala Trp Asp 
65                  70                  75                  80  


His Ile Cys Asn Met Arg Tyr Arg Ala Phe Arg Arg Met Gln Val Trp 
                85                  90                  95      


Asp Ala Cys Ser Glu Ala Leu Ile Met Phe Asp Lys Asp Asn Leu Asp 
            100                 105                 110         


Asp Met Gly Tyr Ile Val Glu Asn Asp Val Ile Met His Ala Leu Thr 
        115                 120                 125             


Lys Gln Leu Glu Ala Val Ser Asp Arg Val Thr Val Leu Tyr Arg Ser 
    130                 135                 140                 


Lys Ala Ile Arg Tyr Thr Trp Pro Cys Pro Phe Pro Met Ala Asp Ser 
145                 150                 155                 160 


Ser Pro Trp Val His Ile Thr Leu Gly Asp Gly Ser Thr Phe Gln Thr 
                165                 170                 175     


Lys Leu Leu Ile Gly Ala Asp Gly His Asn Ser Gly Val Arg Gln Ala 
            180                 185                 190         


Val Gly Ile Gln Asn Val Ser Trp Asn Tyr Asp Gln Ser Ala Val Val 
        195                 200                 205             


Ala Thr Leu His Leu Ser Glu Ala Thr Glu Asn Asn Val Ala Trp Gln 
    210                 215                 220                 


Arg Phe Leu Pro Ser Gly Pro Ile Ala Leu Leu Pro Leu Ser Asp Thr 
225                 230                 235                 240 


Leu Ser Ser Leu Val Trp Ser Thr Ser His Glu His Ala Ala Glu Leu 
                245                 250                 255     


Val Ser Met Asp Glu Glu Lys Phe Val Asp Ala Val Asn Ser Ala Phe 
            260                 265                 270         


Trp Ser Asp Ala Asp His Thr Asp Phe Ile Asp Thr Ala Gly Ala Met 
        275                 280                 285             


Leu Gln Tyr Ala Val Ser Leu Leu Lys Pro Thr Lys Val Ser Ala Arg 
    290                 295                 300                 


Gln Leu Pro Pro Ser Val Ala Arg Val Asp Ala Lys Ser Arg Val Leu 
305                 310                 315                 320 


Phe Pro Leu Gly Leu Gly His Ala Ala Glu Tyr Val Arg Pro Arg Val 
                325                 330                 335     


Ala Leu Ile Gly Asp Ala Ala His Arg Val His Pro Leu Ala Gly Gln 
            340                 345                 350         


Gly Val Asn Met Gly Phe Gly Asp Ile Ser Ser Leu Ala His His Leu 
        355                 360                 365             


Ser Thr Ala Ala Phe Asn Gly Lys Asp Leu Gly Ser Val Ser His Leu 
    370                 375                 380                 


Thr Gly Tyr Glu Thr Glu Arg Gln Arg His Asn Thr Ala Leu Leu Ala 
385                 390                 395                 400 


Ala Thr Asp Leu Leu Lys Arg Leu Tyr Ser Thr Ser Ala Ser Pro Leu 
                405                 410                 415     


Val Leu Leu Arg Thr Trp Gly Leu Gln Ala Thr Asn Ala Val Ser Pro 
            420                 425                 430         


Leu Lys Glu Gln Ile Met Ala Phe Ala Ser Lys 
        435                 440             


<210>  3401
<211>  86
<212>  PRT
<213>  Homo Sapiens

<400>  3401

Met Arg Gly Gln Gly Pro Pro Leu Ser Ser Phe Gly Val Trp Leu Ala 
1               5                   10                  15      


Ser Arg Ala Ala Ser Asp Pro Ser Arg Pro Arg Arg Gln Gly Tyr Asp 
            20                  25                  30          


Ile His Phe His Asp Lys Lys Ile Leu Leu Leu Glu Ala Gly Pro Lys 
        35                  40                  45              


Lys Val Leu Glu Lys Leu Ser Glu Thr Tyr Ser Asn Arg Val Ser Ser 
    50                  55                  60                  


Ile Ser Pro Gly Ser Ala Thr Leu Leu Ser Ser Val Gly Arg Leu Leu 
65                  70                  75                  80  


Arg Gly Pro Asp Asn Val 
                85      


<210>  3402
<211>  105
<212>  PRT
<213>  Homo Sapiens

<400>  3402

Met Pro Leu Ser Pro Gly Leu Leu Leu Leu Leu Leu Ser Gly Ala Thr 
1               5                   10                  15      


Ala Thr Ala Ala Leu Pro Leu Glu Gly Gly Pro Thr Gly Arg Asp Ser 
            20                  25                  30          


Glu His Met Gln Glu Ala Ala Gly Ile Arg Lys Ser Ser Leu Leu Thr 
        35                  40                  45              


Phe Leu Ala Trp Trp Phe Glu Trp Thr Ser Gln Ala Ser Ala Gly Pro 
    50                  55                  60                  


Leu Ile Gly Glu Glu Ala Arg Glu Val Ala Arg Arg Gln Glu Gly Ala 
65                  70                  75                  80  


Pro Pro Gln Gln Ser Ala Arg Arg Asp Arg Met Pro Cys Arg Asn Phe 
                85                  90                  95      


Phe Trp Lys Thr Phe Ser Ser Cys Lys 
            100                 105 


<210>  3403
<211>  225
<212>  PRT
<213>  Homo Sapiens

<400>  3403

Gly Ala Gly Thr Glu Asp Ser Ala Cys Ile Pro Trp Ala Tyr Tyr Ser 
1               5                   10                  15      


Thr Val Asp Gln Val Lys Asp Leu Tyr Ser Gly Leu Ile Gly Pro Leu 
            20                  25                  30          


Ile Val Cys Arg Arg Pro Tyr Leu Lys Val Phe Asn Pro Arg Arg Lys 
        35                  40                  45              


Leu Glu Phe Ala Leu Leu Phe Leu Val Phe Asp Glu Asn Glu Ser Trp 
    50                  55                  60                  


Tyr Leu Asp Asp Asn Ile Lys Thr Tyr Ser Asp His Pro Glu Lys Val 
65                  70                  75                  80  


Asn Lys Asp Asp Glu Glu Phe Ile Glu Ser Asn Lys Met His Ala Ile 
                85                  90                  95      


Asn Gly Arg Met Phe Gly Asn Leu Gln Gly Leu Thr Met His Val Gly 
            100                 105                 110         


Asp Glu Val Asn Trp Tyr Leu Met Gly Met Gly Asn Glu Ile Asp Leu 
        115                 120                 125             


His Thr Val His Phe His Gly His Ser Phe Gln Tyr Lys His Arg Gly 
    130                 135                 140                 


Val Tyr Ser Ser Asp Val Phe Asp Ile Phe Pro Gly Thr Tyr Gln Thr 
145                 150                 155                 160 


Leu Glu Met Phe Pro Arg Thr Pro Gly Ile Trp Leu Leu His Cys His 
                165                 170                 175     


Val Thr Asp His Ile His Ala Gly Met Glu Thr Thr Tyr Thr Val Leu 
            180                 185                 190         


Gln Asn Glu Ala Ser Ser Glu Thr His Arg Arg Ile Trp Asn Val Ile 
        195                 200                 205             


Tyr Pro Ile Thr Val Ser Val Ile Ile Leu Phe Gln Ile Ser Thr Lys 
    210                 215                 220                 


Glu 
225 


<210>  3404
<211>  1065
<212>  PRT
<213>  Homo Sapiens

<400>  3404

Met Lys Ile Leu Ile Leu Gly Ile Phe Leu Phe Leu Cys Ser Thr Pro 
1               5                   10                  15      


Ala Trp Ala Lys Glu Lys His Tyr Tyr Ile Gly Ile Ile Glu Thr Thr 
            20                  25                  30          


Trp Asp Tyr Ala Ser Asp His Gly Glu Lys Lys Leu Ile Ser Val Asp 
        35                  40                  45              


Thr Glu His Ser Asn Ile Tyr Leu Gln Asn Gly Pro Asp Arg Ile Gly 
    50                  55                  60                  


Arg Leu Tyr Lys Lys Ala Leu Tyr Leu Gln Tyr Thr Asp Glu Thr Phe 
65                  70                  75                  80  


Arg Thr Thr Ile Glu Lys Pro Val Trp Leu Gly Phe Leu Gly Pro Ile 
                85                  90                  95      


Ile Lys Ala Glu Thr Gly Asp Lys Val Tyr Val His Leu Lys Asn Leu 
            100                 105                 110         


Ala Ser Arg Pro Tyr Thr Phe His Ser His Gly Ile Thr Tyr Tyr Lys 
        115                 120                 125             


Glu His Glu Gly Ala Ile Tyr Pro Asp Asn Thr Thr Asp Phe Gln Arg 
    130                 135                 140                 


Ala Asp Asp Lys Val Tyr Pro Gly Glu Gln Tyr Thr Tyr Met Leu Leu 
145                 150                 155                 160 


Ala Thr Glu Glu Gln Ser Pro Gly Glu Gly Asp Gly Asn Cys Val Thr 
                165                 170                 175     


Arg Ile Tyr His Ser His Ile Asp Ala Pro Lys Asp Ile Ala Ser Gly 
            180                 185                 190         


Leu Ile Gly Pro Leu Ile Ile Cys Lys Lys Asp Ser Leu Asp Lys Glu 
        195                 200                 205             


Lys Glu Lys His Ile Asp Arg Glu Phe Val Val Met Phe Ser Val Val 
    210                 215                 220                 


Asp Glu Asn Phe Ser Trp Tyr Leu Glu Asp Asn Ile Lys Thr Tyr Cys 
225                 230                 235                 240 


Ser Glu Pro Glu Lys Val Asp Lys Asp Asn Glu Asp Phe Gln Glu Ser 
                245                 250                 255     


Asn Arg Met Tyr Ser Val Asn Gly Tyr Thr Phe Gly Ser Leu Pro Gly 
            260                 265                 270         


Leu Ser Met Cys Ala Glu Asp Arg Val Lys Trp Tyr Leu Phe Gly Met 
        275                 280                 285             


Gly Asn Glu Val Asp Val His Ala Ala Phe Phe His Gly Gln Ala Leu 
    290                 295                 300                 


Thr Asn Lys Asn Tyr Arg Ile Asp Thr Ile Asn Leu Phe Pro Ala Thr 
305                 310                 315                 320 


Leu Phe Asp Ala Tyr Met Val Ala Gln Asn Pro Gly Glu Trp Met Leu 
                325                 330                 335     


Ser Cys Gln Asn Leu Asn His Leu Lys Ala Gly Leu Gln Ala Phe Phe 
            340                 345                 350         


Gln Val Gln Glu Cys Asn Lys Ser Ser Ser Lys Asp Asn Ile Arg Gly 
        355                 360                 365             


Lys His Val Arg His Tyr Tyr Ile Ala Ala Glu Glu Ile Ile Trp Asn 
    370                 375                 380                 


Tyr Ala Pro Ser Gly Ile Asp Ile Phe Thr Lys Glu Asn Leu Thr Ala 
385                 390                 395                 400 


Pro Gly Ser Asp Ser Ala Val Phe Phe Glu Gln Gly Thr Thr Arg Ile 
                405                 410                 415     


Gly Gly Ser Tyr Lys Lys Leu Val Tyr Arg Glu Tyr Thr Asp Ala Ser 
            420                 425                 430         


Phe Thr Asn Arg Lys Glu Arg Gly Pro Glu Glu Glu His Leu Gly Ile 
        435                 440                 445             


Leu Gly Pro Val Ile Trp Ala Glu Val Gly Asp Thr Ile Arg Val Thr 
    450                 455                 460                 


Phe His Asn Lys Gly Ala Tyr Pro Leu Ser Ile Glu Pro Ile Gly Val 
465                 470                 475                 480 


Arg Phe Asn Lys Asn Asn Glu Gly Thr Tyr Tyr Ser Pro Asn Tyr Asn 
                485                 490                 495     


Pro Gln Ser Arg Ser Val Pro Pro Ser Ala Ser His Val Ala Pro Thr 
            500                 505                 510         


Glu Thr Phe Thr Tyr Glu Trp Thr Val Pro Lys Glu Val Gly Pro Thr 
        515                 520                 525             


Asn Ala Asp Pro Val Cys Leu Ala Lys Met Tyr Tyr Ser Ala Val Glu 
    530                 535                 540                 


Pro Thr Lys Asp Ile Phe Thr Gly Leu Ile Gly Pro Met Lys Ile Cys 
545                 550                 555                 560 


Lys Lys Gly Ser Leu His Ala Asn Gly Arg Gln Lys Asp Val Asp Lys 
                565                 570                 575     


Glu Phe Tyr Leu Phe Pro Thr Val Phe Asp Glu Asn Glu Ser Leu Leu 
            580                 585                 590         


Leu Glu Asp Asn Ile Arg Met Phe Thr Thr Ala Pro Asp Gln Val Asp 
        595                 600                 605             


Lys Glu Asp Glu Asp Phe Gln Glu Ser Asn Lys Met His Ser Met Asn 
    610                 615                 620                 


Gly Phe Met Tyr Gly Asn Gln Pro Gly Leu Thr Met Cys Lys Gly Asp 
625                 630                 635                 640 


Ser Val Val Trp Tyr Leu Phe Ser Ala Gly Asn Glu Ala Asp Val His 
                645                 650                 655     


Gly Ile Tyr Phe Ser Gly Asn Thr Tyr Leu Trp Arg Gly Glu Arg Arg 
            660                 665                 670         


Asp Thr Ala Asn Leu Phe Pro Gln Thr Ser Leu Thr Leu His Met Trp 
        675                 680                 685             


Pro Asp Thr Glu Gly Thr Phe Asn Val Glu Cys Leu Thr Thr Asp His 
    690                 695                 700                 


Tyr Thr Gly Gly Met Lys Gln Lys Tyr Thr Val Asn Gln Cys Arg Arg 
705                 710                 715                 720 


Gln Ser Glu Asp Ser Thr Phe Tyr Leu Gly Glu Arg Thr Tyr Tyr Ile 
                725                 730                 735     


Ala Ala Val Glu Val Glu Trp Asp Tyr Ser Pro Gln Arg Glu Trp Glu 
            740                 745                 750         


Lys Glu Leu His His Leu Gln Glu Gln Asn Val Ser Asn Ala Phe Leu 
        755                 760                 765             


Asp Lys Gly Glu Phe Tyr Ile Gly Ser Lys Tyr Lys Lys Val Val Tyr 
    770                 775                 780                 


Arg Gln Tyr Thr Asp Ser Thr Phe Arg Val Pro Val Glu Arg Lys Ala 
785                 790                 795                 800 


Glu Glu Glu His Leu Gly Ile Leu Gly Pro Gln Leu His Ala Asp Val 
                805                 810                 815     


Gly Asp Lys Val Lys Ile Ile Phe Lys Asn Met Ala Thr Arg Pro Tyr 
            820                 825                 830         


Ser Ile His Ala His Gly Val Gln Thr Glu Ser Ser Thr Val Thr Pro 
        835                 840                 845             


Thr Leu Pro Gly Glu Thr Leu Thr Tyr Val Trp Lys Ile Pro Glu Arg 
    850                 855                 860                 


Ser Gly Ala Gly Thr Glu Asp Ser Ala Cys Ile Pro Trp Ala Tyr Tyr 
865                 870                 875                 880 


Ser Thr Val Asp Gln Val Lys Asp Leu Tyr Ser Gly Leu Ile Gly Pro 
                885                 890                 895     


Leu Ile Val Cys Arg Arg Pro Tyr Leu Lys Val Phe Asn Pro Arg Arg 
            900                 905                 910         


Lys Leu Glu Phe Ala Leu Leu Phe Leu Val Phe Asp Glu Asn Glu Ser 
        915                 920                 925             


Trp Tyr Leu Asp Asp Asn Ile Lys Thr Tyr Ser Asp His Pro Glu Lys 
    930                 935                 940                 


Val Asn Lys Asp Asp Glu Glu Phe Ile Glu Ser Asn Lys Met His Ala 
945                 950                 955                 960 


Ile Asn Gly Arg Met Phe Gly Asn Leu Gln Gly Leu Thr Met His Val 
                965                 970                 975     


Gly Asp Glu Val Asn Trp Tyr Leu Met Gly Met Gly Asn Glu Ile Asp 
            980                 985                 990         


Leu His Thr Val His Phe His Gly  His Ser Phe Gln Tyr  Lys His Arg 
        995                 1000                 1005             


Gly Val  Tyr Ser Ser Asp Val  Phe Asp Ile Phe Pro  Gly Thr Tyr 
    1010                 1015                 1020             


Gln Thr  Leu Glu Met Phe Pro  Arg Thr Pro Gly Ile  Trp Leu Leu 
    1025                 1030                 1035             


His Cys  His Val Thr Asp His  Ile His Ala Gly Met  Glu Thr Thr 
    1040                 1045                 1050             


Tyr Thr  Val Leu Gln Asn Glu  Asp Thr Lys Ser Gly  
    1055                 1060                 1065 


<210>  3405
<211>  946
<212>  PRT
<213>  Homo Sapiens

<400>  3405

Met Lys Ile Leu Ile Leu Gly Ile Phe Leu Phe Leu Cys Ser Thr Pro 
1               5                   10                  15      


Ala Trp Ala Lys Glu Lys His Tyr Tyr Ile Gly Ile Ile Glu Thr Thr 
            20                  25                  30          


Trp Asp Tyr Ala Ser Asp His Gly Glu Lys Lys Leu Ile Ser Val Asp 
        35                  40                  45              


Thr Glu His Ser Asn Ile Tyr Leu Gln Asn Gly Pro Asp Arg Ile Gly 
    50                  55                  60                  


Arg Leu Tyr Lys Lys Ala Leu Tyr Leu Gln Tyr Thr Asp Glu Thr Phe 
65                  70                  75                  80  


Arg Thr Thr Ile Glu Lys Pro Val Trp Leu Gly Phe Leu Gly Pro Ile 
                85                  90                  95      


Ile Lys Ala Glu Thr Gly Asp Lys Val Tyr Val His Leu Lys Asn Leu 
            100                 105                 110         


Ala Ser Arg Pro Tyr Thr Phe His Ser His Gly Ile Thr Tyr Tyr Lys 
        115                 120                 125             


Glu His Glu Gly Ala Ile Tyr Pro Asp Asn Thr Thr Asp Phe Gln Arg 
    130                 135                 140                 


Ala Asp Asp Lys Val Tyr Pro Gly Glu Gln Tyr Thr Tyr Met Leu Leu 
145                 150                 155                 160 


Ala Thr Glu Glu Gln Ser Pro Gly Glu Gly Asp Gly Asn Cys Val Thr 
                165                 170                 175     


Arg Ile Tyr His Ser His Ile Asp Ala Pro Lys Asp Ile Ala Ser Gly 
            180                 185                 190         


Leu Ile Gly Pro Leu Ile Ile Cys Lys Lys Asp Ser Leu Asp Lys Glu 
        195                 200                 205             


Lys Glu Lys His Ile Asp Arg Glu Phe Val Val Met Phe Ser Val Val 
    210                 215                 220                 


Asp Glu Asn Phe Ser Trp Tyr Leu Glu Asp Asn Ile Lys Thr Tyr Cys 
225                 230                 235                 240 


Ser Glu Pro Glu Lys Val Asp Lys Asp Asn Glu Asp Phe Gln Glu Ser 
                245                 250                 255     


Asn Arg Met Tyr Ser Val Asn Gly Tyr Thr Phe Gly Ser Leu Pro Gly 
            260                 265                 270         


Leu Ser Met Cys Ala Glu Asp Arg Val Lys Trp Tyr Leu Phe Gly Met 
        275                 280                 285             


Gly Asn Glu Val Asp Val His Ala Ala Phe Phe His Gly Gln Ala Leu 
    290                 295                 300                 


Thr Asn Lys Asn Tyr Arg Ile Asp Thr Ile Asn Leu Phe Pro Ala Thr 
305                 310                 315                 320 


Leu Phe Asp Ala Tyr Met Val Ala Gln Asn Pro Gly Glu Trp Met Leu 
                325                 330                 335     


Ser Cys Gln Asn Leu Asn His Leu Lys Ala Gly Leu Gln Ala Phe Phe 
            340                 345                 350         


Gln Val Gln Glu Cys Asn Lys Ser Ser Ser Lys Asp Asn Ile Arg Gly 
        355                 360                 365             


Lys His Val Arg His Tyr Tyr Ile Ala Ala Glu Glu Ile Ile Trp Asn 
    370                 375                 380                 


Tyr Ala Pro Ser Gly Ile Asp Ile Phe Thr Lys Glu Asn Leu Thr Ala 
385                 390                 395                 400 


Pro Gly Ser Asp Ser Ala Val Phe Phe Glu Gln Gly Thr Thr Arg Ile 
                405                 410                 415     


Gly Gly Ser Tyr Lys Lys Leu Val Tyr Arg Glu Tyr Thr Asp Ala Ser 
            420                 425                 430         


Phe Thr Asn Arg Lys Glu Arg Gly Pro Glu Glu Glu His Leu Gly Ile 
        435                 440                 445             


Leu Gly Pro Val Ile Trp Ala Glu Val Gly Asp Thr Ile Arg Val Thr 
    450                 455                 460                 


Phe His Asn Lys Gly Ala Tyr Pro Leu Ser Ile Glu Pro Ile Gly Val 
465                 470                 475                 480 


Arg Phe Asn Lys Asn Asn Glu Gly Thr Tyr Tyr Ser Pro Asn Tyr Asn 
                485                 490                 495     


Pro Gln Ser Arg Ser Val Pro Pro Ser Ala Ser His Val Ala Pro Thr 
            500                 505                 510         


Glu Thr Phe Thr Tyr Glu Trp Thr Val Pro Lys Glu Val Gly Pro Thr 
        515                 520                 525             


Asn Ala Asp Pro Val Cys Leu Ala Lys Met Tyr Tyr Ser Ala Val Glu 
    530                 535                 540                 


Pro Thr Lys Asp Ile Phe Thr Gly Leu Ile Gly Pro Met Lys Ile Cys 
545                 550                 555                 560 


Lys Lys Gly Ser Leu His Ala Asn Gly Arg Gln Lys Asp Val Asp Lys 
                565                 570                 575     


Glu Phe Tyr Leu Phe Pro Thr Val Phe Asp Glu Asn Glu Ser Leu Leu 
            580                 585                 590         


Leu Glu Asp Asn Ile Arg Met Phe Thr Thr Ala Pro Asp Gln Val Asp 
        595                 600                 605             


Lys Glu Asp Glu Asp Phe Gln Glu Ser Asn Lys Met His Trp Thr Phe 
    610                 615                 620                 


Asn Val Glu Cys Leu Thr Thr Asp His Tyr Thr Gly Gly Met Lys Gln 
625                 630                 635                 640 


Lys Tyr Thr Val Asn Gln Cys Arg Arg Gln Ser Glu Asp Ser Thr Phe 
                645                 650                 655     


Tyr Leu Gly Glu Arg Thr Tyr Tyr Ile Ala Ala Val Glu Val Glu Trp 
            660                 665                 670         


Asp Tyr Ser Pro Gln Arg Glu Trp Glu Lys Glu Leu His His Leu Gln 
        675                 680                 685             


Glu Gln Asn Val Ser Asn Ala Phe Leu Asp Lys Gly Glu Phe Tyr Ile 
    690                 695                 700                 


Gly Ser Lys Tyr Lys Lys Val Val Tyr Arg Gln Tyr Thr Asp Ser Thr 
705                 710                 715                 720 


Phe Arg Val Pro Val Glu Arg Lys Ala Glu Glu Glu His Leu Gly Ile 
                725                 730                 735     


Leu Gly Pro Gln Leu His Ala Asp Val Gly Asp Lys Val Lys Ile Ile 
            740                 745                 750         


Phe Lys Asn Met Ala Thr Arg Pro Tyr Ser Ile His Ala His Gly Val 
        755                 760                 765             


Gln Thr Glu Ser Ser Thr Val Thr Pro Thr Leu Pro Gly Glu Thr Leu 
    770                 775                 780                 


Thr Tyr Val Trp Lys Ile Pro Glu Arg Ser Gly Ala Gly Thr Glu Asp 
785                 790                 795                 800 


Ser Ala Cys Ile Pro Trp Ala Tyr Tyr Ser Thr Val Asp Gln Val Lys 
                805                 810                 815     


Asp Leu Tyr Ser Gly Leu Ile Gly Pro Leu Ile Val Cys Arg Arg Pro 
            820                 825                 830         


Tyr Leu Lys Val Phe Asn Pro Arg Arg Lys Leu Glu Phe Ala Leu Leu 
        835                 840                 845             


Phe Leu Val Phe Asp Glu Asn Glu Ser Trp Tyr Leu Asp Asp Asn Ile 
    850                 855                 860                 


Lys Thr Tyr Ser Asp His Pro Glu Lys Val Asn Lys Asp Asp Glu Glu 
865                 870                 875                 880 


Phe Ile Glu Ser Asn Lys Met His Ala Ile Asn Gly Arg Met Phe Gly 
                885                 890                 895     


Asn Leu Gln Gly Leu Thr Met His Val Gly Asp Glu Val Asn Trp Tyr 
            900                 905                 910         


Leu Met Gly Met Gly Asn Glu Ile Asp Leu His Thr Val His Phe His 
        915                 920                 925             


Gly His Ser Phe Gln Tyr Lys His Leu Leu Arg Leu Thr Gly Glu Tyr 
    930                 935                 940                 


Gly Met 
945     


<210>  3406
<211>  179
<212>  PRT
<213>  Homo Sapiens

<400>  3406

Met Lys Ile Leu Ile Leu Gly Ile Phe Leu Phe Leu Cys Ser Thr Pro 
1               5                   10                  15      


Ala Trp Ala Lys Glu Lys His Tyr Tyr Ile Gly Ile Ile Glu Thr Thr 
            20                  25                  30          


Trp Asp Tyr Ala Ser Asp His Gly Glu Lys Lys Leu Ile Ser Val Asp 
        35                  40                  45              


Thr Gly Phe Gln Asn Lys Trp Tyr Ser Glu Asp Val Thr Ile Ser Arg 
    50                  55                  60                  


Pro Asn Asp Gln Glu Glu Ile Thr Ala Gln Ile Leu Thr Lys Lys Leu 
65                  70                  75                  80  


Asp Asn Lys Glu His Ser Thr Leu Arg Glu His Ser Asn Ile Tyr Leu 
                85                  90                  95      


Gln Asn Gly Pro Asp Arg Ile Gly Arg Leu Tyr Lys Lys Ala Leu Tyr 
            100                 105                 110         


Leu Gln Tyr Thr Asp Glu Thr Phe Arg Thr Thr Ile Glu Lys Pro Val 
        115                 120                 125             


Trp Leu Gly Phe Leu Gly Pro Ile Ile Lys Ala Glu Thr Gly Asp Lys 
    130                 135                 140                 


Val Tyr Val His Leu Lys Asn Leu Ala Ser Arg Pro Tyr Thr Phe His 
145                 150                 155                 160 


Ser His Gly Ile Thr Tyr Tyr Lys Glu His Glu Gly Ala Ile Tyr Pro 
                165                 170                 175     


Asp Asn Thr 
            


<210>  3407
<211>  852
<212>  PRT
<213>  Homo Sapiens

<400>  3407

Val Val Met Phe Ser Val Val Asp Glu Asn Phe Ser Trp Tyr Leu Glu 
1               5                   10                  15      


Asp Asn Ile Lys Thr Tyr Cys Ser Glu Pro Glu Lys Val Asp Lys Asp 
            20                  25                  30          


Asn Glu Asp Phe Gln Glu Ser Asn Arg Met Tyr Ser Val Asn Gly Tyr 
        35                  40                  45              


Thr Phe Gly Ser Leu Pro Gly Leu Ser Met Cys Ala Glu Asp Arg Val 
    50                  55                  60                  


Lys Trp Tyr Leu Phe Gly Met Gly Asn Glu Val Asp Val His Ala Ala 
65                  70                  75                  80  


Phe Phe His Gly Gln Ala Leu Thr Asn Lys Asn Tyr Arg Ile Asp Thr 
                85                  90                  95      


Ile Asn Leu Phe Pro Ala Thr Leu Phe Asp Ala Tyr Met Val Ala Gln 
            100                 105                 110         


Asn Pro Gly Glu Trp Met Leu Ser Cys Gln Asn Leu Asn His Leu Lys 
        115                 120                 125             


Ala Gly Leu Gln Ala Phe Phe Gln Val Gln Glu Cys Asn Lys Ser Ser 
    130                 135                 140                 


Ser Lys Asp Asn Ile Arg Gly Lys His Val Arg His Tyr Tyr Ile Ala 
145                 150                 155                 160 


Ala Glu Glu Ile Ile Trp Asn Tyr Ala Pro Ser Gly Ile Asp Ile Phe 
                165                 170                 175     


Thr Lys Glu Asn Leu Thr Ala Pro Gly Ser Asp Ser Ala Val Phe Phe 
            180                 185                 190         


Glu Gln Gly Thr Thr Arg Ile Gly Gly Ser Tyr Lys Lys Leu Val Tyr 
        195                 200                 205             


Arg Glu Tyr Thr Asp Ala Ser Phe Thr Asn Arg Lys Glu Arg Gly Pro 
    210                 215                 220                 


Glu Glu Glu His Leu Gly Ile Leu Gly Pro Val Ile Trp Ala Glu Val 
225                 230                 235                 240 


Gly Asp Thr Ile Arg Val Thr Phe His Asn Lys Gly Ala Tyr Pro Leu 
                245                 250                 255     


Ser Ile Glu Pro Ile Gly Val Arg Phe Asn Lys Asn Asn Glu Gly Thr 
            260                 265                 270         


Tyr Tyr Ser Pro Asn Tyr Asn Pro Gln Ser Arg Ser Val Pro Pro Ser 
        275                 280                 285             


Ala Ser His Val Ala Pro Thr Glu Thr Phe Thr Tyr Glu Trp Thr Val 
    290                 295                 300                 


Pro Lys Glu Val Gly Pro Thr Asn Ala Asp Pro Val Cys Leu Ala Lys 
305                 310                 315                 320 


Met Tyr Tyr Ser Ala Val Glu Pro Thr Lys Asp Ile Phe Thr Gly Leu 
                325                 330                 335     


Ile Gly Pro Met Lys Ile Cys Lys Lys Gly Ser Leu His Ala Asn Gly 
            340                 345                 350         


Arg Gln Lys Asp Val Asp Lys Glu Phe Tyr Leu Phe Pro Thr Val Phe 
        355                 360                 365             


Asp Glu Asn Glu Ser Leu Leu Leu Glu Asp Asn Ile Arg Met Phe Thr 
    370                 375                 380                 


Thr Ala Pro Asp Gln Val Asp Lys Glu Asp Glu Asp Phe Gln Glu Ser 
385                 390                 395                 400 


Asn Lys Met His Ser Met Asn Gly Phe Met Tyr Gly Asn Gln Pro Gly 
                405                 410                 415     


Leu Thr Met Cys Lys Gly Asp Ser Val Val Trp Tyr Leu Phe Ser Ala 
            420                 425                 430         


Gly Asn Glu Ala Asp Val His Gly Ile Tyr Phe Ser Gly Asn Thr Tyr 
        435                 440                 445             


Leu Trp Arg Gly Glu Arg Arg Asp Thr Ala Asn Leu Phe Pro Gln Thr 
    450                 455                 460                 


Ser Leu Thr Leu His Met Trp Pro Asp Thr Glu Gly Thr Phe Asn Val 
465                 470                 475                 480 


Glu Cys Leu Thr Thr Asp His Tyr Thr Gly Gly Met Lys Gln Lys Tyr 
                485                 490                 495     


Thr Val Asn Gln Cys Arg Arg Gln Ser Glu Asp Ser Thr Phe Tyr Leu 
            500                 505                 510         


Gly Glu Arg Thr Tyr Tyr Ile Ala Ala Val Glu Val Glu Trp Asp Tyr 
        515                 520                 525             


Ser Pro Gln Arg Glu Trp Glu Lys Glu Leu His His Leu Gln Glu Gln 
    530                 535                 540                 


Asn Val Ser Asn Ala Phe Leu Asp Lys Gly Glu Phe Tyr Ile Gly Ser 
545                 550                 555                 560 


Lys Tyr Lys Lys Val Val Tyr Arg Gln Tyr Thr Asp Ser Thr Phe Arg 
                565                 570                 575     


Val Pro Val Glu Arg Lys Ala Glu Glu Glu His Leu Gly Ile Leu Gly 
            580                 585                 590         


Pro Gln Leu His Ala Asp Val Gly Asp Lys Val Lys Ile Ile Phe Lys 
        595                 600                 605             


Asn Met Ala Thr Arg Pro Tyr Ser Ile His Ala His Gly Val Gln Thr 
    610                 615                 620                 


Glu Ser Ser Thr Val Thr Pro Thr Leu Pro Gly Glu Thr Leu Thr Tyr 
625                 630                 635                 640 


Val Trp Lys Ile Pro Glu Arg Ser Gly Ala Gly Thr Glu Asp Ser Ala 
                645                 650                 655     


Cys Ile Pro Trp Ala Tyr Tyr Ser Thr Val Asp Gln Val Lys Asp Leu 
            660                 665                 670         


Tyr Ser Gly Leu Ile Gly Pro Leu Ile Val Cys Arg Arg Pro Tyr Leu 
        675                 680                 685             


Lys Val Phe Asn Pro Arg Arg Lys Leu Glu Phe Ala Leu Leu Phe Leu 
    690                 695                 700                 


Val Phe Asp Glu Asn Glu Ser Trp Tyr Leu Asp Asp Asn Ile Lys Thr 
705                 710                 715                 720 


Tyr Ser Asp His Pro Glu Lys Val Asn Lys Asp Asp Glu Glu Phe Ile 
                725                 730                 735     


Glu Ser Asn Lys Met His Ala Ile Asn Gly Arg Met Phe Gly Asn Leu 
            740                 745                 750         


Gln Gly Leu Thr Met His Val Gly Asp Glu Val Asn Trp Tyr Leu Met 
        755                 760                 765             


Gly Met Gly Asn Glu Ile Asp Leu His Thr Val His Phe His Gly His 
    770                 775                 780                 


Ser Phe Gln Tyr Lys His Arg Gly Val Tyr Ser Ser Asp Val Phe Asp 
785                 790                 795                 800 


Ile Phe Pro Gly Thr Tyr Gln Thr Leu Glu Met Phe Pro Arg Thr Pro 
                805                 810                 815     


Gly Ile Trp Leu Leu His Cys His Val Thr Asp His Ile His Ala Gly 
            820                 825                 830         


Met Glu Thr Thr Tyr Thr Val Leu Gln Asn Glu Gly Glu Tyr Pro Asp 
        835                 840                 845             


Thr Lys Ser Gly 
    850         


<210>  3408
<211>  103
<212>  PRT
<213>  Homo Sapiens

<400>  3408

Met Ile Glu Asp Val Gln Ser Leu Leu Asp Glu Glu Gln Glu Gln Met 
1               5                   10                  15      


Phe Ala Phe Arg Ser Arg Ala Arg Ser Thr Asp Thr Phe Asn Tyr Ala 
            20                  25                  30          


Thr Tyr His Thr Leu Glu Glu Ile Tyr Asp Phe Leu Asp Leu Leu Val 
        35                  40                  45              


Ala Glu Asn Pro His Leu Val Ser Lys Ile Gln Ile Gly Asn Thr Tyr 
    50                  55                  60                  


Glu Gly Arg Pro Ile Tyr Val Leu Lys Phe Ser Thr Gly Gly Ser Lys 
65                  70                  75                  80  


Arg Pro Ala Ile Trp Ile Asp Thr Gly Ile His Ser Arg Glu Trp Val 
                85                  90                  95      


Thr Gln Ala Ser Gly Val Trp 
            100             


<210>  3409
<211>  331
<212>  PRT
<213>  Homo Sapiens

<400>  3409

Met Ile Glu Asp Val Gln Ser Leu Leu Asp Glu Glu Gln Glu Gln Met 
1               5                   10                  15      


Phe Ala Phe Arg Ser Arg Ala Arg Ser Thr Asp Thr Phe Asn Tyr Ala 
            20                  25                  30          


Thr Tyr His Thr Leu Glu Glu Ile Tyr Asp Phe Leu Asp Leu Leu Val 
        35                  40                  45              


Ala Glu Asn Pro His Leu Val Ser Lys Ile Gln Ile Gly Asn Thr Tyr 
    50                  55                  60                  


Glu Gly Arg Pro Ile Tyr Val Leu Lys Phe Ser Thr Gly Gly Ser Lys 
65                  70                  75                  80  


Arg Pro Ala Ile Trp Ile Asp Thr Gly Ile His Ser Arg Glu Trp Val 
                85                  90                  95      


Thr Gln Ala Ser Gly Val Trp Phe Ala Lys Lys Ile Thr Gln Asp Tyr 
            100                 105                 110         


Gly Gln Asp Ala Ala Phe Thr Ala Ile Leu Asp Thr Leu Asp Ile Phe 
        115                 120                 125             


Leu Glu Ile Val Thr Asn Pro Asp Gly Phe Ala Phe Thr His Ser Thr 
    130                 135                 140                 


Asn Arg Met Trp Arg Lys Thr Arg Ser His Thr Ala Gly Ser Leu Cys 
145                 150                 155                 160 


Ile Gly Val Asp Pro Asn Arg Asn Trp Asp Ala Gly Phe Gly Leu Ser 
                165                 170                 175     


Gly Ala Ser Ser Asn Pro Cys Ser Glu Thr Tyr His Gly Lys Phe Ala 
            180                 185                 190         


Asn Ser Glu Val Glu Val Lys Ser Ile Val Asp Phe Val Lys Asp His 
        195                 200                 205             


Gly Asn Ile Lys Ala Phe Ile Ser Ile His Ser Tyr Ser Gln Leu Leu 
    210                 215                 220                 


Met Tyr Pro Tyr Gly Tyr Lys Thr Glu Pro Val Pro Asp Gln Asp Glu 
225                 230                 235                 240 


Leu Asp Gln Leu Ser Lys Ala Ala Val Thr Ala Leu Ala Ser Leu Tyr 
                245                 250                 255     


Gly Thr Lys Phe Asn Tyr Gly Ser Ile Ile Lys Ala Ile Tyr Gln Ala 
            260                 265                 270         


Ser Gly Ser Thr Ile Asp Trp Thr Tyr Ser Gln Gly Ile Lys Tyr Ser 
        275                 280                 285             


Phe Thr Phe Glu Leu Arg Asp Thr Gly Arg Tyr Gly Phe Leu Leu Pro 
    290                 295                 300                 


Ala Ser Gln Ile Ile Pro Thr Ala Lys Glu Thr Trp Leu Ala Leu Leu 
305                 310                 315                 320 


Thr Ile Met Glu His Thr Leu Asn His Pro Tyr 
                325                 330     


<210>  3410
<211>  269
<212>  PRT
<213>  Homo Sapiens

<400>  3410

Met Ile Glu Asp Val Gln Ser Leu Leu Asp Glu Glu Gln Glu Gln Met 
1               5                   10                  15      


Phe Ala Phe Arg Ser Arg Ala Arg Ser Thr Asp Thr Phe Asn Tyr Ala 
            20                  25                  30          


Thr Tyr His Thr Leu Glu Glu Ile Tyr Asp Phe Leu Asp Leu Leu Val 
        35                  40                  45              


Ala Glu Asn Pro His Leu Val Ser Lys Ile Gln Ile Gly Asn Thr Tyr 
    50                  55                  60                  


Glu Gly Arg Pro Ile Tyr Val Leu Lys Phe Ser Thr Gly Gly Ser Lys 
65                  70                  75                  80  


Arg Pro Ala Ile Trp Ile Asp Thr Gly Ile His Ser Arg Glu Trp Val 
                85                  90                  95      


Thr Gln Ala Ser Gly Val Trp Phe Ala Lys Lys Ile Thr Gln Asp Tyr 
            100                 105                 110         


Gly Gln Asp Ala Ala Phe Thr Ala Ile Leu Asp Thr Leu Asp Ile Phe 
        115                 120                 125             


Leu Glu Ile Val Thr Asn Pro Asp Gly Phe Ala Phe Thr His Ser Thr 
    130                 135                 140                 


Asn Arg Met Trp Arg Lys Thr Arg Ser His Thr Ala Gly Ser Leu Cys 
145                 150                 155                 160 


Ile Gly Val Asp Pro Asn Arg Asn Trp Asp Ala Gly Phe Gly Leu Ser 
                165                 170                 175     


Gly Ala Ser Ser Asn Pro Cys Ser Glu Thr Tyr His Gly Lys Phe Ala 
            180                 185                 190         


Asn Ser Glu Val Glu Val Lys Ser Ile Val Asp Phe Val Lys Asp His 
        195                 200                 205             


Gly Asn Ile Lys Ala Phe Ile Ser Ile His Ser Tyr Ser Gln Leu Leu 
    210                 215                 220                 


Met Tyr Pro Tyr Gly Tyr Lys Thr Glu Pro Val Pro Asp Gln Asp Glu 
225                 230                 235                 240 


Leu Asp Gln Leu Ser Lys Ala Ala Val Thr Ala Leu Ala Ser Leu Tyr 
                245                 250                 255     


Gly Thr Lys Phe Asn Tyr Gly Ser Ile Ile Lys Ala Ile 
            260                 265                 


<210>  3411
<211>  419
<212>  PRT
<213>  Homo Sapiens

<400>  3411

Met Arg Gly Leu Leu Val Leu Ser Val Leu Leu Gly Ala Val Phe Gly 
1               5                   10                  15      


Lys Glu Asp Phe Val Gly His Gln Val Leu Arg Ile Ser Val Ala Asp 
            20                  25                  30          


Glu Ala Gln Val Gln Lys Val Lys Glu Leu Glu Asp Leu Glu His Leu 
        35                  40                  45              


Gln Leu Asp Phe Trp Arg Gly Pro Ala His Pro Gly Ser Pro Ile Asp 
    50                  55                  60                  


Val Arg Val Pro Phe Pro Ser Ile Gln Ala Val Lys Ile Phe Leu Glu 
65                  70                  75                  80  


Ser His Gly Ile Ser Tyr Glu Thr Met Ile Glu Asp Val Gln Ser Leu 
                85                  90                  95      


Leu Asp Glu Glu Gln Glu Gln Met Phe Ala Phe Arg Ser Arg Ala Arg 
            100                 105                 110         


Ser Thr Asp Thr Phe Asn Tyr Ala Thr Tyr His Thr Leu Glu Glu Ile 
        115                 120                 125             


Tyr Asp Phe Leu Asp Leu Leu Val Ala Glu Asn Pro His Leu Val Ser 
    130                 135                 140                 


Lys Ile Gln Ile Gly Asn Thr Tyr Glu Gly Arg Pro Ile Tyr Val Leu 
145                 150                 155                 160 


Lys Phe Ser Thr Gly Gly Ser Lys Arg Pro Ala Ile Trp Ile Asp Thr 
                165                 170                 175     


Gly Ile His Ser Arg Glu Trp Val Thr Gln Ala Ser Gly Val Trp Phe 
            180                 185                 190         


Ala Lys Lys Ile Thr Gln Asp Tyr Gly Gln Asp Ala Ala Phe Thr Ala 
        195                 200                 205             


Ile Leu Asp Thr Leu Asp Ile Phe Leu Glu Ile Val Thr Asn Pro Asp 
    210                 215                 220                 


Gly Phe Ala Phe Thr His Ser Thr Asn Arg Met Trp Arg Lys Thr Arg 
225                 230                 235                 240 


Ser His Thr Ala Gly Ser Leu Cys Ile Gly Val Asp Pro Asn Arg Asn 
                245                 250                 255     


Trp Asp Ala Gly Phe Gly Leu Ser Gly Ala Ser Ser Asn Pro Cys Ser 
            260                 265                 270         


Glu Thr Tyr His Gly Lys Phe Ala Asn Ser Glu Val Glu Val Lys Ser 
        275                 280                 285             


Ile Val Asp Phe Val Lys Asp His Gly Asn Ile Lys Ala Phe Ile Ser 
    290                 295                 300                 


Ile His Ser Tyr Ser Gln Leu Leu Met Tyr Pro Tyr Gly Tyr Lys Thr 
305                 310                 315                 320 


Glu Pro Val Pro Asp Gln Asp Glu Leu Asp Gln Leu Ser Lys Ala Ala 
                325                 330                 335     


Val Thr Ala Leu Ala Ser Leu Tyr Gly Thr Lys Phe Asn Tyr Gly Ser 
            340                 345                 350         


Ile Ile Lys Ala Ile Tyr Gln Ala Ser Gly Ser Thr Ile Asp Trp Thr 
        355                 360                 365             


Tyr Ser Gln Gly Ile Lys Tyr Ser Phe Thr Phe Glu Leu Arg Asp Thr 
    370                 375                 380                 


Gly Arg Tyr Gly Phe Leu Leu Pro Ala Ser Gln Ile Ile Pro Thr Ala 
385                 390                 395                 400 


Lys Glu Thr Trp Leu Ala Leu Leu Thr Ile Met Glu His Thr Leu Asn 
                405                 410                 415     


His Pro Tyr 
            


<210>  3412
<211>  191
<212>  PRT
<213>  Homo Sapiens

<400>  3412

Ser Leu Thr Phe Pro Pro Gly Ser Ser Met Arg Gly Leu Leu Val Leu 
1               5                   10                  15      


Ser Val Leu Leu Gly Ala Val Phe Gly Lys Glu Asp Phe Val Gly His 
            20                  25                  30          


Gln Val Leu Arg Ile Ser Val Ala Asp Glu Ala Gln Val Gln Lys Ile 
        35                  40                  45              


Thr Gln Asp Tyr Gly Gln Asp Ala Ala Phe Thr Ala Ile Leu Asp Thr 
    50                  55                  60                  


Leu Asp Ile Phe Leu Glu Ile Val Thr Asn Pro Asp Gly Phe Ala Phe 
65                  70                  75                  80  


Thr His Ser Thr Asn Arg Met Trp Arg Lys Thr Arg Ser His Thr Ala 
                85                  90                  95      


Gly Ser Leu Cys Ile Gly Val Asp Pro Asn Arg Asn Trp Asp Ala Gly 
            100                 105                 110         


Phe Gly Leu Ser Gly Ala Ser Ser Asn Pro Cys Ser Glu Thr Tyr His 
        115                 120                 125             


Gly Lys Phe Ala Asn Ser Glu Val Glu Val Lys Ser Ile Val Asp Phe 
    130                 135                 140                 


Val Lys Asp His Gly Asn Ile Lys Ala Phe Ile Ser Ile His Ser Tyr 
145                 150                 155                 160 


Ser Gln Leu Leu Met Tyr Pro Tyr Gly Tyr Lys Thr Glu Pro Val Pro 
                165                 170                 175     


Asp Gln Asp Glu Leu Asp Gln Leu Ser Lys Ala Ala Val Thr Ala 
            180                 185                 190     


<210>  3413
<211>  419
<212>  PRT
<213>  Homo Sapiens

<400>  3413

Met Ala Met Arg Leu Ile Leu Phe Phe Gly Ala Leu Phe Gly His Ile 
1               5                   10                  15      


Tyr Cys Leu Glu Thr Phe Val Gly Asp Gln Val Leu Glu Ile Val Pro 
            20                  25                  30          


Ser Asn Glu Glu Gln Ile Lys Asn Leu Leu Gln Leu Glu Ala Gln Glu 
        35                  40                  45              


His Leu Gln Leu Asp Phe Trp Lys Ser Pro Thr Thr Pro Gly Glu Thr 
    50                  55                  60                  


Ala His Val Arg Val Pro Phe Val Asn Val Gln Ala Val Lys Val Phe 
65                  70                  75                  80  


Leu Glu Ser Gln Gly Ile Ala Tyr Ser Ile Met Ile Glu Asp Val Gln 
                85                  90                  95      


Val Leu Leu Asp Lys Glu Asn Glu Glu Met Leu Phe Asn Arg Arg Arg 
            100                 105                 110         


Glu Arg Ser Gly Asn Phe Asn Phe Gly Ala Tyr His Thr Leu Glu Glu 
        115                 120                 125             


Ile Ser Gln Glu Met Asp Asn Leu Val Ala Glu His Pro Gly Leu Val 
    130                 135                 140                 


Ser Lys Val Asn Ile Gly Ser Ser Phe Glu Asn Arg Pro Met Asn Val 
145                 150                 155                 160 


Leu Lys Phe Ser Thr Gly Gly Asp Lys Pro Ala Ile Trp Leu Asp Ala 
                165                 170                 175     


Gly Ile His Ala Arg Glu Trp Val Thr Gln Ala Thr Ala Leu Trp Thr 
            180                 185                 190         


Ala Asn Lys Ile Val Ser Asp Tyr Gly Lys Asp Pro Ser Ile Thr Ser 
        195                 200                 205             


Ile Leu Asp Ala Leu Asp Ile Phe Leu Leu Pro Val Thr Asn Pro Asp 
    210                 215                 220                 


Gly Tyr Val Phe Ser Gln Thr Lys Asn Arg Met Trp Arg Lys Thr Arg 
225                 230                 235                 240 


Ser Lys Val Ser Gly Ser Leu Cys Val Gly Val Asp Pro Asn Arg Asn 
                245                 250                 255     


Trp Asp Ala Gly Phe Gly Gly Pro Gly Ala Ser Ser Asn Pro Cys Ser 
            260                 265                 270         


Asp Ser Tyr His Gly Pro Ser Ala Asn Ser Glu Val Glu Val Lys Ser 
        275                 280                 285             


Ile Val Asp Phe Ile Lys Ser His Gly Lys Val Lys Ala Phe Ile Thr 
    290                 295                 300                 


Leu His Ser Tyr Ser Gln Leu Leu Met Phe Pro Tyr Gly Tyr Lys Cys 
305                 310                 315                 320 


Thr Lys Leu Asp Asp Phe Asp Glu Leu Ser Glu Val Ala Gln Lys Ala 
                325                 330                 335     


Ala Gln Ser Leu Arg Ser Leu His Gly Thr Lys Tyr Lys Val Gly Pro 
            340                 345                 350         


Ile Cys Ser Val Ile Tyr Gln Ala Ser Gly Gly Ser Ile Asp Trp Ser 
        355                 360                 365             


Tyr Asp Tyr Gly Ile Lys Tyr Ser Phe Ala Phe Glu Leu Arg Asp Thr 
    370                 375                 380                 


Gly Arg Tyr Gly Phe Leu Leu Pro Ala Arg Gln Ile Leu Pro Thr Ala 
385                 390                 395                 400 


Glu Glu Thr Trp Leu Gly Leu Lys Ala Ile Met Glu His Val Arg Asp 
                405                 410                 415     


His Pro Tyr 
            


<210>  3414
<211>  182
<212>  PRT
<213>  Homo Sapiens

<400>  3414

Met Arg Leu Ile Leu Phe Phe Gly Ala Leu Phe Gly His Ile Tyr Cys 
1               5                   10                  15      


Leu Glu Thr Phe Val Gly Asp Gln Val Leu Glu Ile Val Pro Ser Asn 
            20                  25                  30          


Glu Glu Gln Ile Lys Asn Leu Leu Gln Leu Glu Ala Gln Glu His Leu 
        35                  40                  45              


Gln Leu Asp Phe Trp Lys Ser Pro Thr Thr Pro Gly Glu Thr Ala His 
    50                  55                  60                  


Val Arg Val Pro Phe Val Asn Val Gln Ala Val Lys Val Phe Leu Glu 
65                  70                  75                  80  


Ser Gln Gly Ile Ala Tyr Ser Ile Met Ile Glu Asp Val Gln Val Leu 
                85                  90                  95      


Leu Asp Lys Glu Asn Glu Glu Met Leu Phe Asn Arg Arg Arg Glu Arg 
            100                 105                 110         


Ser Gly Asn Phe Asn Phe Gly Ala Tyr His Thr Leu Glu Glu Ile Ser 
        115                 120                 125             


Gln Glu Met Asp Asn Leu Val Ala Glu His Pro Gly Leu Val Ser Lys 
    130                 135                 140                 


Val Asn Ile Gly Ser Ser Phe Glu Asn Arg Pro Met Asn Val Leu Lys 
145                 150                 155                 160 


Lys Ser Ser Gly Arg Met Gln Lys Asp Asp Gly Gln Leu Asn Pro Lys 
                165                 170                 175     


Pro Gln Arg Gln Thr Pro 
            180         


<210>  3415
<211>  417
<212>  PRT
<213>  Homo Sapiens

<400>  3415

Met Arg Leu Ile Leu Pro Val Gly Leu Ile Ala Thr Thr Leu Ala Ile 
1               5                   10                  15      


Ala Pro Val Arg Phe Asp Arg Glu Lys Val Phe Arg Val Lys Pro Gln 
            20                  25                  30          


Asp Glu Lys Gln Ala Asp Ile Ile Lys Asp Leu Ala Lys Thr Asn Glu 
        35                  40                  45              


Leu Asp Phe Trp Tyr Pro Gly Ala Thr His His Val Ala Ala Asn Met 
    50                  55                  60                  


Met Val Asp Phe Arg Val Ser Glu Lys Glu Ser Gln Ala Ile Gln Ser 
65                  70                  75                  80  


Ala Leu Asp Gln Asn Lys Met His Tyr Glu Ile Leu Ile His Asp Leu 
                85                  90                  95      


Gln Glu Glu Ile Glu Lys Gln Phe Asp Val Lys Glu Asp Ile Pro Gly 
            100                 105                 110         


Arg His Ser Tyr Ala Lys Tyr Asn Asn Trp Glu Lys Ile Val Ala Trp 
        115                 120                 125             


Thr Glu Lys Met Met Asp Lys Tyr Pro Glu Met Val Ser Arg Ile Lys 
    130                 135                 140                 


Ile Gly Ser Thr Val Glu Asp Asn Pro Leu Tyr Val Leu Lys Ile Gly 
145                 150                 155                 160 


Glu Lys Asn Glu Arg Arg Lys Ala Ile Phe Thr Asp Cys Gly Ile His 
                165                 170                 175     


Ala Arg Glu Trp Val Ser Pro Ala Phe Cys Gln Trp Phe Val Tyr Gln 
            180                 185                 190         


Ala Thr Lys Thr Tyr Gly Arg Asn Lys Ile Met Thr Lys Leu Leu Asp 
        195                 200                 205             


Arg Met Asn Phe Tyr Ile Leu Pro Val Phe Asn Val Asp Gly Tyr Ile 
    210                 215                 220                 


Trp Ser Trp Thr Lys Asn Arg Met Trp Arg Lys Asn Arg Ser Lys Asn 
225                 230                 235                 240 


Gln Asn Ser Lys Cys Ile Gly Thr Asp Leu Asn Arg Asn Phe Asn Ala 
                245                 250                 255     


Ser Trp Asn Ser Ile Pro Asn Thr Asn Asp Pro Cys Ala Asp Asn Tyr 
            260                 265                 270         


Arg Gly Ser Ala Pro Glu Ser Glu Lys Glu Thr Lys Ala Val Thr Asn 
        275                 280                 285             


Phe Ile Arg Ser His Leu Asn Glu Ile Lys Val Tyr Ile Thr Phe His 
    290                 295                 300                 


Ser Tyr Ser Gln Met Leu Leu Phe Pro Tyr Gly Tyr Thr Ser Lys Leu 
305                 310                 315                 320 


Pro Pro Asn His Glu Asp Leu Ala Lys Val Ala Lys Ile Gly Thr Asp 
                325                 330                 335     


Val Leu Ser Thr Arg Tyr Glu Thr Arg Tyr Ile Tyr Gly Pro Ile Glu 
            340                 345                 350         


Ser Thr Ile Tyr Pro Ile Ser Gly Ser Ser Leu Asp Trp Ala Tyr Asp 
        355                 360                 365             


Leu Gly Ile Lys His Thr Phe Ala Phe Glu Leu Arg Asp Lys Gly Lys 
    370                 375                 380                 


Phe Gly Phe Leu Leu Pro Glu Ser Arg Ile Lys Pro Thr Cys Arg Glu 
385                 390                 395                 400 


Thr Met Leu Ala Val Lys Phe Ile Ala Lys Tyr Ile Leu Lys His Thr 
                405                 410                 415     


Ser 
    


<210>  3416
<211>  29
<212>  PRT
<213>  Homo Sapiens

<400>  3416

Met Gln His Asn Glu Gly Gln Glu Arg Ser Ser Asn Asn Phe Asn Tyr 
1               5                   10                  15      


Gly Ala Tyr His Ser Leu Glu Ala Ile Tyr His Glu Met 
            20                  25                  


<210>  3417
<211>  317
<212>  PRT
<213>  Homo Sapiens

<400>  3417

Met Gln His Asn Glu Gly Gln Glu Arg Ser Ser Asn Asn Phe Asn Tyr 
1               5                   10                  15      


Gly Ala Tyr His Ser Leu Glu Ala Ile Tyr His Glu Met Asp Asn Ile 
            20                  25                  30          


Ala Ala Asp Phe Pro Asp Leu Ala Arg Arg Val Lys Ile Gly His Ser 
        35                  40                  45              


Phe Glu Asn Arg Pro Met Tyr Val Leu Lys Phe Ser Thr Gly Lys Gly 
    50                  55                  60                  


Val Arg Arg Pro Ala Val Trp Leu Asn Ala Gly Ile His Ser Arg Glu 
65                  70                  75                  80  


Trp Ile Ser Gln Ala Thr Ala Ile Trp Thr Ala Arg Lys Ile Val Ser 
                85                  90                  95      


Asp Tyr Gln Arg Asp Pro Ala Ile Thr Ser Ile Leu Glu Lys Met Asp 
            100                 105                 110         


Ile Phe Leu Leu Pro Val Ala Asn Pro Asp Gly Tyr Val Tyr Thr Gln 
        115                 120                 125             


Thr Gln Asn Arg Leu Trp Arg Lys Thr Arg Ser Arg Asn Pro Gly Ser 
    130                 135                 140                 


Ser Cys Ile Gly Ala Asp Pro Asn Arg Asn Trp Asn Ala Ser Phe Ala 
145                 150                 155                 160 


Gly Lys Gly Ala Ser Asp Asn Pro Cys Ser Glu Val Tyr His Gly Pro 
                165                 170                 175     


His Ala Asn Ser Glu Val Glu Val Lys Ser Val Val Asp Phe Ile Gln 
            180                 185                 190         


Lys His Gly Asn Phe Lys Gly Phe Ile Asp Leu His Ser Tyr Ser Gln 
        195                 200                 205             


Leu Leu Met Tyr Pro Tyr Gly Tyr Ser Val Lys Lys Ala Pro Asp Ala 
    210                 215                 220                 


Glu Glu Leu Asp Lys Val Ala Arg Leu Ala Ala Lys Ala Leu Ala Ser 
225                 230                 235                 240 


Val Ser Gly Thr Glu Tyr Gln Val Gly Pro Thr Cys Thr Thr Val Tyr 
                245                 250                 255     


Pro Ala Ser Gly Ser Ser Ile Asp Trp Ala Tyr Asp Asn Gly Ile Lys 
            260                 265                 270         


Phe Ala Phe Thr Phe Glu Leu Arg Asp Thr Gly Thr Tyr Gly Phe Leu 
        275                 280                 285             


Leu Pro Ala Asn Gln Ile Ile Pro Thr Ala Glu Glu Thr Trp Leu Gly 
    290                 295                 300                 


Leu Lys Thr Ile Met Glu His Val Arg Asp Asn Leu Tyr 
305                 310                 315         


<210>  3418
<211>  421
<212>  PRT
<213>  Homo Sapiens

<400>  3418

Met Arg Trp Ile Leu Phe Ile Gly Ala Leu Ile Gly Ser Ser Ile Cys 
1               5                   10                  15      


Gly Gln Glu Lys Phe Phe Gly Asp Gln Val Leu Arg Ile Asn Val Arg 
            20                  25                  30          


Asn Gly Asp Glu Ile Ser Lys Leu Ser Gln Leu Val Asn Ser Asn Asn 
        35                  40                  45              


Leu Lys Leu Asn Phe Trp Lys Ser Pro Ser Ser Phe Asn Arg Pro Val 
    50                  55                  60                  


Asp Val Leu Val Pro Ser Val Ser Leu Gln Ala Phe Lys Ser Phe Leu 
65                  70                  75                  80  


Arg Ser Gln Gly Leu Glu Tyr Ala Val Thr Ile Glu Asp Leu Gln Ala 
                85                  90                  95      


Leu Leu Asp Asn Glu Asp Asp Glu Met Gln His Asn Glu Gly Gln Glu 
            100                 105                 110         


Arg Ser Ser Asn Asn Phe Asn Tyr Gly Ala Tyr His Ser Leu Glu Ala 
        115                 120                 125             


Ile Tyr His Glu Met Asp Asn Ile Ala Ala Asp Phe Pro Asp Leu Ala 
    130                 135                 140                 


Arg Arg Val Lys Ile Gly His Ser Phe Glu Asn Arg Pro Met Tyr Val 
145                 150                 155                 160 


Leu Lys Phe Ser Thr Gly Lys Gly Val Arg Arg Pro Ala Val Trp Leu 
                165                 170                 175     


Asn Ala Gly Ile His Ser Arg Glu Trp Ile Ser Gln Ala Thr Ala Ile 
            180                 185                 190         


Trp Thr Ala Arg Lys Ile Val Ser Asp Tyr Gln Arg Asp Pro Ala Ile 
        195                 200                 205             


Thr Ser Ile Leu Glu Lys Met Asp Ile Phe Leu Leu Pro Val Ala Asn 
    210                 215                 220                 


Pro Asp Gly Tyr Val Tyr Thr Gln Thr Gln Asn Arg Leu Trp Arg Lys 
225                 230                 235                 240 


Thr Arg Ser Arg Asn Pro Gly Ser Ser Cys Ile Gly Ala Asp Pro Asn 
                245                 250                 255     


Arg Asn Trp Asn Ala Ser Phe Ala Gly Lys Gly Ala Ser Asp Asn Pro 
            260                 265                 270         


Cys Ser Glu Val Tyr His Gly Pro His Ala Asn Ser Glu Val Glu Val 
        275                 280                 285             


Lys Ser Val Val Asp Phe Ile Gln Lys His Gly Asn Phe Lys Gly Phe 
    290                 295                 300                 


Ile Asp Leu His Ser Tyr Ser Gln Leu Leu Met Tyr Pro Tyr Gly Tyr 
305                 310                 315                 320 


Ser Val Lys Lys Ala Pro Asp Ala Glu Glu Leu Asp Lys Val Ala Arg 
                325                 330                 335     


Leu Ala Ala Lys Ala Leu Ala Ser Val Ser Gly Thr Glu Tyr Gln Val 
            340                 345                 350         


Gly Pro Thr Cys Thr Thr Val Tyr Pro Ala Ser Gly Ser Ser Ile Asp 
        355                 360                 365             


Trp Ala Tyr Asp Asn Gly Ile Lys Phe Ala Phe Thr Phe Glu Leu Arg 
    370                 375                 380                 


Asp Thr Gly Thr Tyr Gly Phe Leu Leu Pro Ala Asn Gln Ile Ile Pro 
385                 390                 395                 400 


Thr Ala Glu Glu Thr Trp Leu Gly Leu Lys Thr Ile Met Glu His Val 
                405                 410                 415     


Arg Asp Asn Leu Tyr 
            420     


<210>  3419
<211>  172
<212>  PRT
<213>  Homo Sapiens

<400>  3419

Met Arg Trp Ile Leu Phe Ile Gly Ala Leu Ile Gly Ser Ser Ile Cys 
1               5                   10                  15      


Gly Gln Glu Lys Phe Phe Gly Asp Gln Val Leu Arg Ile Asn Val Arg 
            20                  25                  30          


Asn Gly Asp Glu Ile Ser Lys Leu Ser Gln Leu Val Asn Ser Asn Asn 
        35                  40                  45              


Leu Lys Leu Asn Phe Trp Lys Ser Pro Ser Ser Phe Asn Arg Pro Val 
    50                  55                  60                  


Asp Val Leu Val Pro Ser Val Ser Leu Gln Ala Phe Lys Ser Phe Leu 
65                  70                  75                  80  


Arg Ser Gln Gly Leu Glu Tyr Ala Val Thr Ile Glu Asp Leu Gln Ala 
                85                  90                  95      


Leu Leu Asp Asn Glu Asp Asp Glu Met Gln His Asn Glu Gly Gln Glu 
            100                 105                 110         


Arg Ser Ser Asn Asn Phe Asn Tyr Gly Ala Tyr His Ser Leu Glu Ala 
        115                 120                 125             


Ile Tyr His Glu Met Asp Asn Ile Ala Ala Asp Phe Pro Asp Leu Ala 
    130                 135                 140                 


Arg Arg Val Lys Ile Gly His Ser Phe Glu Asn Arg Pro Met Tyr Val 
145                 150                 155                 160 


Leu Lys Ile Val Ser Asp Tyr Gln Arg Asp Pro Ala 
                165                 170         


<210>  3420
<211>  177
<212>  PRT
<213>  Homo Sapiens

<400>  3420

Met Arg Trp Ile Leu Phe Ile Gly Ala Leu Ile Gly Ser Ser Ile Cys 
1               5                   10                  15      


Gly Gln Glu Lys Phe Phe Gly Asp Gln Val Leu Arg Ile Asn Val Arg 
            20                  25                  30          


Asn Gly Asp Glu Ile Ser Lys Leu Ser Gln Leu Val Asn Ser Asn Asn 
        35                  40                  45              


Leu Lys Leu Asn Phe Trp Lys Ser Pro Ser Ser Phe Asn Arg Pro Val 
    50                  55                  60                  


Asp Val Leu Val Pro Ser Val Ser Leu Gln Ala Phe Lys Ser Phe Leu 
65                  70                  75                  80  


Arg Ser Gln Gly Leu Glu Tyr Ala Val Thr Ile Glu Asp Leu Gln Ile 
                85                  90                  95      


Tyr His Glu Met Asp Asn Ile Ala Ala Asp Phe Pro Asp Leu Ala Arg 
            100                 105                 110         


Arg Val Lys Ile Gly His Ser Phe Glu Asn Arg Pro Met Tyr Val Leu 
        115                 120                 125             


Lys Phe Ser Thr Gly Lys Gly Val Arg Arg Pro Ala Val Trp Leu Asn 
    130                 135                 140                 


Ala Gly Ile His Ser Arg Glu Trp Ile Ser Gln Ala Thr Ala Ile Trp 
145                 150                 155                 160 


Thr Ala Arg Lys Ile Val Ser Asp Tyr Gln Arg Asp Pro Ala Ile Thr 
                165                 170                 175     


Ser 
    


<210>  3421
<211>  388
<212>  PRT
<213>  Homo Sapiens

<400>  3421

Met Arg Trp Ile Leu Phe Ile Gly Ala Leu Ile Gly Ser Ser Ile Cys 
1               5                   10                  15      


Gly Gln Glu Lys Phe Phe Gly Asp Gln Val Leu Arg Ile Asn Val Arg 
            20                  25                  30          


Asn Gly Asp Glu Ile Ser Lys Leu Ser Gln Leu Val Asn Ser Asn Asn 
        35                  40                  45              


Leu Lys Leu Asn Phe Trp Lys Ser Pro Ser Ser Phe Asn Arg Pro Val 
    50                  55                  60                  


Asp Val Leu Val Pro Ser Val Ser Leu Gln Ala Phe Lys Ser Phe Leu 
65                  70                  75                  80  


Arg Ser Gln Gly Leu Glu Tyr Ala Val Thr Ile Glu Asp Leu Gln Ile 
                85                  90                  95      


Tyr His Glu Met Asp Asn Ile Ala Ala Asp Phe Pro Asp Leu Ala Arg 
            100                 105                 110         


Arg Val Lys Ile Gly His Ser Phe Glu Asn Arg Pro Met Tyr Val Leu 
        115                 120                 125             


Lys Phe Ser Thr Gly Lys Gly Val Arg Arg Pro Ala Val Trp Leu Asn 
    130                 135                 140                 


Ala Gly Ile His Ser Arg Glu Trp Ile Ser Gln Ala Thr Ala Ile Trp 
145                 150                 155                 160 


Thr Ala Arg Lys Ile Val Ser Asp Tyr Gln Arg Asp Pro Ala Ile Thr 
                165                 170                 175     


Ser Ile Leu Glu Lys Met Asp Ile Phe Leu Leu Pro Val Ala Asn Pro 
            180                 185                 190         


Asp Gly Tyr Val Tyr Thr Gln Thr Gln Asn Arg Leu Trp Arg Lys Thr 
        195                 200                 205             


Arg Ser Arg Asn Pro Gly Ser Ser Cys Ile Gly Ala Asp Pro Asn Arg 
    210                 215                 220                 


Asn Trp Asn Ala Ser Phe Ala Gly Lys Gly Ala Ser Asp Asn Pro Cys 
225                 230                 235                 240 


Ser Glu Val Tyr His Gly Pro His Ala Asn Ser Glu Val Glu Val Lys 
                245                 250                 255     


Ser Val Val Asp Phe Ile Gln Lys His Gly Asn Phe Lys Gly Phe Ile 
            260                 265                 270         


Asp Leu His Ser Tyr Ser Gln Leu Leu Met Tyr Pro Tyr Gly Tyr Ser 
        275                 280                 285             


Val Lys Lys Ala Pro Asp Ala Glu Glu Leu Asp Lys Val Ala Arg Leu 
    290                 295                 300                 


Ala Ala Lys Ala Leu Ala Ser Val Ser Gly Thr Glu Tyr Gln Val Gly 
305                 310                 315                 320 


Pro Thr Cys Thr Thr Val Tyr Pro Ala Ser Gly Ser Ser Ile Asp Trp 
                325                 330                 335     


Ala Tyr Asp Asn Gly Ile Lys Phe Ala Phe Thr Phe Glu Leu Arg Asp 
            340                 345                 350         


Thr Gly Thr Tyr Gly Phe Leu Leu Pro Ala Asn Gln Ile Ile Pro Thr 
        355                 360                 365             


Ala Glu Glu Thr Trp Leu Gly Leu Lys Thr Ile Met Glu His Val Arg 
    370                 375                 380                 


Asp Asn Leu Tyr 
385             


<210>  3422
<211>  92
<212>  PRT
<213>  Homo Sapiens

<400>  3422

Met Lys Cys Leu Gly Lys Arg Arg Gly Gln Ala Ala Ala Phe Leu Pro 
1               5                   10                  15      


Leu Cys Trp Leu Phe Leu Lys Ile Leu Gln Pro Gly His Ser His Leu 
            20                  25                  30          


Tyr Asn Asn Arg Tyr Ala Gly Asp Lys Val Ile Arg Phe Ile Pro Lys 
        35                  40                  45              


Thr Glu Glu Glu Ala Tyr Ala Leu Lys Lys Ile Ser Tyr Gln Leu Lys 
    50                  55                  60                  


Gly Pro His Arg Arg Ser Ser Glu Asn Thr Gly Glu Gly Lys Gln Leu 
65                  70                  75                  80  


Ala His Pro Glu Lys Pro Lys Ile Pro Leu Trp Ile 
                85                  90          


<210>  3423
<211>  92
<212>  PRT
<213>  Homo Sapiens

<400>  3423

Met Lys Cys Leu Gly Lys Arg Arg Gly Gln Ala Ala Ala Phe Leu Pro 
1               5                   10                  15      


Leu Cys Trp Leu Phe Leu Lys Ile Leu Gln Pro Gly His Ser His Leu 
            20                  25                  30          


Tyr Asn Asn Arg Tyr Ala Gly Asp Lys Val Ile Arg Phe Ile Pro Lys 
        35                  40                  45              


Thr Glu Glu Glu Ala Tyr Ala Leu Lys Lys Ile Ser Tyr Gln Leu Lys 
    50                  55                  60                  


Gly Pro His Arg Arg Ser Ser Glu Asn Thr Gly Glu Gly Lys Gln Leu 
65                  70                  75                  80  


Ala His Pro Glu Lys Pro Lys Ile Pro Leu Trp Ile 
                85                  90          


<210>  3424
<211>  437
<212>  PRT
<213>  Homo Sapiens

<400>  3424

Met Lys Cys Leu Gly Lys Arg Arg Gly Gln Ala Ala Ala Phe Leu Pro 
1               5                   10                  15      


Leu Cys Trp Leu Phe Leu Lys Ile Leu Gln Pro Gly His Ser His Leu 
            20                  25                  30          


Tyr Asn Asn Arg Tyr Ala Gly Asp Lys Val Ile Arg Phe Ile Pro Lys 
        35                  40                  45              


Thr Glu Glu Glu Ala Tyr Ala Leu Lys Lys Ile Ser Tyr Gln Leu Lys 
    50                  55                  60                  


Val Asp Leu Trp Gln Pro Ser Ser Ile Ser Tyr Val Ser Glu Gly Thr 
65                  70                  75                  80  


Val Thr Asp Val His Ile Pro Gln Asn Gly Ser Arg Ala Leu Leu Ala 
                85                  90                  95      


Phe Leu Gln Glu Ala Asn Ile Gln Tyr Lys Val Leu Ile Glu Asp Leu 
            100                 105                 110         


Gln Lys Thr Leu Glu Lys Gly Ser Ser Leu His Thr Gln Arg Asn Arg 
        115                 120                 125             


Arg Ser Leu Ser Gly Tyr Asn Tyr Glu Val Tyr His Ser Leu Glu Glu 
    130                 135                 140                 


Ile Gln Asn Trp Met His His Leu Asn Lys Thr His Ser Gly Leu Ile 
145                 150                 155                 160 


His Met Phe Ser Ile Gly Arg Ser Tyr Glu Gly Arg Ser Leu Phe Ile 
                165                 170                 175     


Leu Lys Leu Gly Arg Arg Ser Arg Leu Lys Arg Ala Val Trp Ile Asp 
            180                 185                 190         


Cys Gly Ile His Ala Arg Glu Trp Ile Gly Pro Ala Phe Cys Gln Trp 
        195                 200                 205             


Phe Val Lys Glu Ala Leu Leu Thr Tyr Lys Ser Asp Pro Ala Met Arg 
    210                 215                 220                 


Lys Met Leu Asn His Leu Tyr Phe Tyr Ile Met Pro Val Phe Asn Val 
225                 230                 235                 240 


Asp Gly Tyr His Phe Ser Trp Thr Asn Asp Arg Phe Trp Arg Lys Thr 
                245                 250                 255     


Arg Ser Arg Asn Ser Arg Phe Arg Cys Arg Gly Val Asp Ala Asn Arg 
            260                 265                 270         


Asn Trp Lys Val Lys Trp Cys Asp Glu Gly Ala Ser Met His Pro Cys 
        275                 280                 285             


Asp Asp Thr Tyr Cys Gly Pro Phe Pro Glu Ser Glu Pro Glu Val Lys 
    290                 295                 300                 


Ala Val Ala Asn Phe Leu Arg Lys His Arg Lys His Ile Arg Ala Tyr 
305                 310                 315                 320 


Leu Ser Phe His Ala Tyr Ala Gln Met Leu Leu Tyr Pro Tyr Ser Tyr 
                325                 330                 335     


Lys Tyr Ala Thr Ile Pro Asn Phe Arg Cys Val Glu Ser Ala Ala Tyr 
            340                 345                 350         


Lys Ala Val Asn Ala Leu Gln Ser Val Tyr Gly Val Arg Tyr Arg Tyr 
        355                 360                 365             


Gly Pro Ala Ser Thr Thr Leu Tyr Val Ser Ser Gly Ser Ser Met Asp 
    370                 375                 380                 


Trp Ala Tyr Lys Asn Gly Ile Pro Tyr Ala Phe Ala Phe Glu Leu Arg 
385                 390                 395                 400 


Asp Thr Gly Tyr Phe Gly Phe Leu Leu Pro Glu Met Leu Ile Lys Pro 
                405                 410                 415     


Thr Cys Thr Glu Thr Met Leu Ala Val Lys Asn Ile Thr Met His Leu 
            420                 425                 430         


Leu Lys Lys Cys Pro 
        435         


<210>  3425
<211>  175
<212>  PRT
<213>  Homo Sapiens

<400>  3425

Leu Leu Leu Asp Lys His Met Gly Met Lys Arg Tyr Glu Val Ala Gly 
1               5                   10                  15      


Arg Arg Val Leu Phe Tyr Phe Asp Glu Ile Pro Ser Arg Cys Leu Thr 
            20                  25                  30          


Cys Val Arg Phe Arg Ala Leu Arg Glu Cys Val Val Gly Arg Thr Ser 
        35                  40                  45              


Ala Leu Pro Val Ser Val Tyr Asp Tyr Tyr Glu Pro Ala Phe Glu Ala 
    50                  55                  60                  


Thr Arg Phe Tyr Asn Val Ser Thr His Ser Pro Leu Ala Arg Glu Leu 
65                  70                  75                  80  


Cys Ala Gly Pro Ala Cys Asn Glu Val Glu Arg Ala Pro Ala Arg Gly 
                85                  90                  95      


Pro Gly Trp Phe Pro Gly Glu Ser Gly Pro Ala Val Ala Pro Glu Glu 
            100                 105                 110         


Gly Ala Ala Ile Ala Arg Cys Gly Cys Asp His Asp Cys Gly Ala Gln 
        115                 120                 125             


Gly Asn Pro Val Cys Gly Ser Asp Gly Val Val Tyr Ala Ser Ala Cys 
    130                 135                 140                 


Arg Leu Arg Glu Ala Ala Cys Arg Gln Ala Ala Pro Leu Glu Pro Ala 
145                 150                 155                 160 


Pro Pro Ser Cys Cys Ala Leu Ala Gly Arg Glu Ala Glu Trp Ser 
                165                 170                 175 


<210>  3426
<211>  550
<212>  PRT
<213>  Homo Sapiens

<400>  3426

Met Ala Pro Gly Ala Leu Arg Gly Gly Cys Glu Gln Arg Ala Pro Gly 
1               5                   10                  15      


Gly Gly Ala Arg Thr Ala Ala Leu Gly Pro Trp Pro Trp Pro Ser Pro 
            20                  25                  30          


Gly Pro Ala Pro Ser Pro Gly Ala Ala Pro Pro Arg Ser Arg Lys Met 
        35                  40                  45              


Ser Gly Ala Leu Leu Trp Pro Leu Leu Pro Leu Leu Leu Leu Leu Leu 
    50                  55                  60                  


Ser Ala Arg Asp Gly Val Arg Ala Ala Gln Pro Gln Ala Pro Gly Tyr 
65                  70                  75                  80  


Leu Ile Ala Ala Pro Ser Val Phe Arg Ala Gly Val Glu Glu Val Ile 
                85                  90                  95      


Ser Val Thr Ile Phe Asn Ser Pro Arg Glu Val Thr Val Gln Ala Gln 
            100                 105                 110         


Leu Val Ala Gln Gly Glu Pro Val Val Gln Ser Gln Gly Ala Ile Leu 
        115                 120                 125             


Asp Lys Gly Thr Ile Lys Leu Lys Val Pro Thr Gly Leu Arg Gly Gln 
    130                 135                 140                 


Ala Leu Leu Lys Val Trp Gly Arg Gly Trp Gln Ala Glu Glu Gly Pro 
145                 150                 155                 160 


Leu Phe His Asn Gln Thr Ser Val Thr Val Asp Gly Arg Gly Ala Ser 
                165                 170                 175     


Val Phe Ile Gln Thr Asp Lys Pro Val Tyr Arg Pro Gln His Arg Val 
            180                 185                 190         


Leu Ile Ser Ile Phe Thr Val Ser Pro Asn Leu Arg Pro Val Asn Glu 
        195                 200                 205             


Lys Leu Glu Ala Tyr Ile Leu Asp Pro Arg Gly Ser Arg Met Ile Glu 
    210                 215                 220                 


Trp Arg His Leu Lys Pro Phe Cys Cys Gly Ile Thr Asn Met Ser Phe 
225                 230                 235                 240 


Pro Leu Ser Asp Gln Pro Val Leu Gly Glu Trp Phe Ile Phe Val Glu 
                245                 250                 255     


Met Gln Gly His Ala Tyr Asn Lys Ser Phe Glu Val Gln Lys Tyr Val 
            260                 265                 270         


Leu Pro Lys Phe Glu Leu Leu Ile Asp Pro Pro Arg Tyr Ile Gln Asp 
        275                 280                 285             


Leu Asp Ala Cys Glu Thr Gly Thr Val Arg Ala Arg Tyr Thr Phe Gly 
    290                 295                 300                 


Lys Pro Val Ala Gly Ala Leu Met Ile Asn Met Thr Val Asn Gly Val 
305                 310                 315                 320 


Gly Tyr Tyr Ser His Glu Val Gly Arg Pro Val Leu Arg Thr Thr Lys 
                325                 330                 335     


Ile Leu Gly Ser Arg Asp Phe Asp Ile Cys Val Arg Asp Met Ile Pro 
            340                 345                 350         


Ala Asp Val Pro Glu His Phe Arg Gly Arg Val Ser Ile Trp Ala Met 
        355                 360                 365             


Val Thr Ser Val Asp Gly Ser Gln Gln Val Ala Phe Asp Asp Ser Thr 
    370                 375                 380                 


Pro Val Gln Arg Gln Leu Val Asp Ile Arg Tyr Ser Lys Asp Thr Arg 
385                 390                 395                 400 


Lys Gln Phe Lys Pro Gly Leu Ala Tyr Val Gly Lys Val Glu Leu Ser 
                405                 410                 415     


Tyr Pro Asp Gly Ser Pro Ala Glu Gly Val Thr Val Gln Ile Lys Ala 
            420                 425                 430         


Glu Leu Thr Pro Lys Asp Asn Ile Tyr Thr Ser Glu Val Val Ser Gln 
        435                 440                 445             


Arg Gly Leu Val Gly Phe Glu Ile Pro Ser Ile Pro Thr Ser Ala Gln 
    450                 455                 460                 


His Val Trp Leu Glu Val Phe Gln Glu Leu Glu Asp Tyr Asp Val Ser 
465                 470                 475                 480 


Asp Ser Phe Gly Val Ser Arg Glu Asp Gly Pro Phe Trp Trp Ala Gly 
                485                 490                 495     


Leu Thr Ala Gln Arg Arg Arg Arg Ser Ser Val Phe Pro Trp Pro Trp 
            500                 505                 510         


Gly Ile Thr Lys Asp Ser Gly Phe Ala Phe Thr Val Arg Arg Gly Asn 
        515                 520                 525             


Gly Thr Gly Gly Asp Asp Arg Pro Ser Glu Pro Glu Pro Pro Ala Gly 
    530                 535                 540                 


Arg Trp Pro Leu His Arg 
545                 550 


<210>  3427
<211>  1932
<212>  PRT
<213>  Homo Sapiens

<400>  3427

Met Ala Pro Gly Ala Leu Arg Gly Gly Cys Glu Gln Arg Ala Pro Gly 
1               5                   10                  15      


Gly Gly Ala Arg Thr Ala Ala Leu Gly Pro Trp Pro Trp Pro Ser Pro 
            20                  25                  30          


Gly Pro Ala Pro Ser Pro Gly Ala Ala Pro Pro Arg Ser Arg Lys Met 
        35                  40                  45              


Ser Gly Ala Leu Leu Trp Pro Leu Leu Pro Leu Leu Leu Leu Leu Leu 
    50                  55                  60                  


Ser Ala Arg Asp Gly Val Arg Ala Ala Gln Pro Gln Ala Pro Gly Tyr 
65                  70                  75                  80  


Leu Ile Ala Ala Pro Ser Val Phe Arg Ala Gly Val Glu Glu Val Ile 
                85                  90                  95      


Ser Val Thr Ile Phe Asn Ser Pro Arg Glu Val Thr Val Gln Ala Gln 
            100                 105                 110         


Leu Val Ala Gln Gly Glu Pro Val Val Gln Ser Gln Gly Ala Ile Leu 
        115                 120                 125             


Asp Lys Gly Thr Ile Lys Leu Lys Val Pro Thr Gly Leu Arg Gly Gln 
    130                 135                 140                 


Ala Leu Leu Lys Val Trp Gly Arg Gly Trp Gln Ala Glu Glu Gly Pro 
145                 150                 155                 160 


Leu Phe His Asn Gln Thr Ser Val Thr Val Asp Gly Arg Gly Ala Ser 
                165                 170                 175     


Val Phe Ile Gln Thr Asp Lys Pro Val Tyr Arg Pro Gln His Arg Val 
            180                 185                 190         


Leu Ile Ser Ile Phe Thr Val Ser Pro Asn Leu Arg Pro Val Asn Glu 
        195                 200                 205             


Lys Leu Glu Ala Tyr Ile Leu Asp Pro Arg Gly Ser Arg Met Ile Glu 
    210                 215                 220                 


Trp Arg His Leu Lys Pro Phe Cys Cys Gly Ile Thr Asn Met Ser Phe 
225                 230                 235                 240 


Pro Leu Ser Asp Gln Pro Val Leu Gly Glu Trp Phe Ile Phe Val Glu 
                245                 250                 255     


Met Gln Gly His Ala Tyr Asn Lys Ser Phe Glu Val Gln Lys Tyr Val 
            260                 265                 270         


Leu Pro Lys Phe Glu Leu Leu Ile Asp Pro Pro Arg Tyr Ile Gln Asp 
        275                 280                 285             


Leu Asp Ala Cys Glu Thr Gly Thr Val Arg Ala Arg Tyr Thr Phe Gly 
    290                 295                 300                 


Lys Pro Val Ala Gly Ala Leu Met Ile Asn Met Thr Val Asn Gly Val 
305                 310                 315                 320 


Gly Tyr Tyr Ser His Glu Val Gly Arg Pro Val Leu Arg Thr Thr Lys 
                325                 330                 335     


Ile Leu Gly Ser Arg Asp Phe Asp Ile Cys Val Arg Asp Met Ile Pro 
            340                 345                 350         


Ala Asp Val Pro Glu His Phe Arg Gly Arg Val Ser Ile Trp Ala Met 
        355                 360                 365             


Val Thr Ser Val Asp Gly Ser Gln Gln Val Ala Phe Asp Asp Ser Thr 
    370                 375                 380                 


Pro Val Gln Arg Gln Leu Val Asp Ile Arg Tyr Ser Lys Asp Thr Arg 
385                 390                 395                 400 


Lys Gln Phe Lys Pro Gly Leu Ala Tyr Val Gly Lys Val Glu Leu Ser 
                405                 410                 415     


Tyr Pro Asp Gly Ser Pro Ala Glu Gly Val Thr Val Gln Ile Lys Ala 
            420                 425                 430         


Glu Leu Thr Pro Lys Asp Asn Ile Tyr Thr Ser Glu Val Val Ser Gln 
        435                 440                 445             


Arg Gly Leu Val Gly Phe Glu Ile Pro Ser Ile Pro Thr Ser Ala Gln 
    450                 455                 460                 


His Val Trp Leu Glu Thr Lys Val Met Ala Leu Asn Gly Lys Pro Val 
465                 470                 475                 480 


Gly Ala Gln Tyr Leu Pro Ser Tyr Leu Ser Leu Gly Ser Trp Tyr Ser 
                485                 490                 495     


Pro Ser Gln Cys Tyr Leu Gln Leu Gln Pro Pro Ser His Pro Leu Gln 
            500                 505                 510         


Val Gly Glu Glu Ala Tyr Phe Ser Val Lys Ser Thr Cys Pro Cys Asn 
        515                 520                 525             


Phe Thr Leu Tyr Tyr Glu Val Ala Ala Arg Gly Asn Ile Val Leu Ser 
    530                 535                 540                 


Gly Gln Gln Pro Ala His Thr Thr Gln Gln Arg Ser Lys Arg Ala Ala 
545                 550                 555                 560 


Pro Ala Leu Glu Lys Pro Ile Arg Leu Thr His Leu Ser Glu Thr Glu 
                565                 570                 575     


Pro Pro Pro Ala Pro Glu Ala Glu Val Asp Val Cys Val Thr Ser Leu 
            580                 585                 590         


His Leu Ala Val Thr Pro Ser Met Val Pro Leu Gly Arg Leu Leu Val 
        595                 600                 605             


Phe Tyr Val Arg Glu Asn Gly Glu Gly Val Ala Asp Ser Leu Gln Phe 
    610                 615                 620                 


Ala Val Glu Thr Phe Phe Glu Asn Gln Val Ser Val Thr Tyr Ser Ala 
625                 630                 635                 640 


Asn Glu Thr Gln Pro Gly Glu Val Val Asp Leu Arg Ile Arg Ala Ala 
                645                 650                 655     


Arg Gly Ser Cys Val Cys Val Ala Ala Val Asp Lys Ser Val Tyr Leu 
            660                 665                 670         


Leu Arg Ser Gly Phe Arg Leu Thr Pro Ala Gln Val Phe Gln Glu Leu 
        675                 680                 685             


Glu Asp Tyr Asp Val Ser Asp Ser Phe Gly Val Ser Arg Glu Asp Gly 
    690                 695                 700                 


Pro Phe Trp Trp Ala Gly Leu Thr Ala Gln Arg Arg Arg Arg Ser Ser 
705                 710                 715                 720 


Val Phe Pro Trp Pro Trp Gly Ile Thr Lys Asp Ser Gly Phe Ala Phe 
                725                 730                 735     


Thr Glu Thr Gly Leu Val Val Met Thr Asp Arg Val Ser Leu Asn His 
            740                 745                 750         


Arg Gln Asp Gly Gly Leu Tyr Thr Asp Glu Ala Val Pro Ala Phe Gln 
        755                 760                 765             


Pro His Thr Gly Ser Leu Val Ala Val Ala Pro Ser Arg His Pro Pro 
    770                 775                 780                 


Arg Thr Glu Lys Arg Lys Arg Thr Phe Phe Pro Glu Thr Trp Ile Trp 
785                 790                 795                 800 


His Cys Leu Asn Ile Ser Asp Pro Ser Gly Glu Gly Thr Leu Ser Val 
                805                 810                 815     


Lys Val Pro Asp Ser Ile Thr Ser Trp Val Gly Glu Ala Val Ala Leu 
            820                 825                 830         


Ser Thr Ser Gln Gly Leu Gly Ile Ala Glu Pro Ser Leu Leu Lys Thr 
        835                 840                 845             


Phe Lys Pro Phe Phe Val Asp Phe Met Leu Pro Ala Leu Ile Ile Arg 
    850                 855                 860                 


Gly Glu Gln Val Lys Ile Pro Leu Ser Val Tyr Asn Tyr Met Gly Thr 
865                 870                 875                 880 


Cys Ala Glu Val Tyr Met Lys Leu Ser Val Pro Lys Gly Ile Gln Phe 
                885                 890                 895     


Val Gly His Pro Gly Lys Arg His Val Thr Lys Lys Met Cys Val Ala 
            900                 905                 910         


Pro Gly Glu Ala Glu Pro Ile Trp Val Val Leu Ser Phe Ser Asp Leu 
        915                 920                 925             


Gly Leu Asn Asn Ile Thr Ala Lys Ala Leu Ala Tyr Gly Asp Thr Asn 
    930                 935                 940                 


Cys Cys Arg Asp Gly Arg Ser Ser Lys His Pro Glu Glu Asn His Ala 
945                 950                 955                 960 


Asp Arg Arg Val Pro Ile Gly Val Asp His Val Arg Arg Ser Val Met 
                965                 970                 975     


Val Glu Ala Glu Gly Val Pro Arg Ala Tyr Thr Tyr Ser Ala Phe Phe 
            980                 985                 990         


Cys Pro Ser Glu Arg Val His Ile  Ser Thr Pro Asn Lys  Tyr Glu Phe 
        995                 1000                 1005             


Gln Tyr  Val Gln Arg Pro Leu  Arg Leu Thr Arg Phe  Asp Val Ala 
    1010                 1015                 1020             


Val Arg  Ala His Asn Asp Ala  Arg Val Ala Leu Ser  Ser Gly Pro 
    1025                 1030                 1035             


Gln Asp  Thr Ala Gly Met Ile  Glu Ile Val Leu Gly  Gly His Gln 
    1040                 1045                 1050             


Asn Thr  Arg Ser Trp Ile Ser  Thr Ser Lys Met Gly  Glu Pro Val 
    1055                 1060                 1065             


Ala Ser  Ala His Thr Ala Lys  Ile Leu Ser Trp Asp  Glu Phe Arg 
    1070                 1075                 1080             


Thr Phe  Trp Ile Ser Trp Arg  Gly Gly Leu Ile Gln  Val Gly His 
    1085                 1090                 1095             


Gly Pro  Glu Pro Ser Asn Glu  Ser Val Ile Val Ala  Trp Thr Leu 
    1100                 1105                 1110             


Pro Arg  Pro Pro Glu Val Gln  Phe Ile Gly Phe Ser  Thr Gly Trp 
    1115                 1120                 1125             


Gly Ser  Met Gly Glu Phe Arg  Ile Trp Arg Lys Met  Glu Val Asp 
    1130                 1135                 1140             


Glu Ser  Tyr Ser Glu Ala Phe  Thr Leu Gly Val Pro  His Gly Ala 
    1145                 1150                 1155             


Ile Pro  Gly Ser Glu Arg Ala  Thr Ala Ser Ile Ile  Gly Asp Val 
    1160                 1165                 1170             


Met Gly  Pro Thr Leu Asn His  Leu Asn Asn Leu Leu  Arg Leu Pro 
    1175                 1180                 1185             


Phe Gly  Cys Gly Glu Gln Asn  Met Ile His Phe Ala  Pro Asn Val 
    1190                 1195                 1200             


Phe Val  Leu Lys Tyr Leu Gln  Lys Thr Gln Gln Leu  Ser Pro Glu 
    1205                 1210                 1215             


Val Glu  Arg Glu Thr Thr Asp  Tyr Leu Val Gln Gly  Tyr Gln Arg 
    1220                 1225                 1230             


Gln Leu  Thr Tyr Lys Arg Gln  Asp Gly Ser Tyr Ser  Ala Phe Gly 
    1235                 1240                 1245             


Glu Arg  Asp Ala Ser Gly Ser  Met Trp Leu Thr Ala  Phe Val Leu 
    1250                 1255                 1260             


Lys Ser  Phe Ala Gln Ala Arg  Ser Phe Ile Phe Val  Asp Pro Arg 
    1265                 1270                 1275             


Glu Leu  Ala Ala Ala Lys Ser  Trp Ile Ile Gln Gln  Gln Gln Ala 
    1280                 1285                 1290             


Asp Gly  Ser Phe Leu Ala Val  Gly Arg Val Leu Asn  Lys Asp Ile 
    1295                 1300                 1305             


Gln Gly  Gly Ile His Gly Thr  Val Pro Leu Thr Ala  Tyr Val Val 
    1310                 1315                 1320             


Val Ala  Leu Leu Glu Thr Gly  Thr Ala Ser Glu Glu  Glu Arg Gly 
    1325                 1330                 1335             


Ser Thr  Asp Lys Ala Arg His  Phe Leu Glu Ser Ala  Ala Pro Leu 
    1340                 1345                 1350             


Ala Met  Asp Pro Tyr Ser Cys  Ala Leu Thr Thr Tyr  Ala Leu Thr 
    1355                 1360                 1365             


Leu Leu  Arg Ser Pro Ala Ala  Pro Glu Ala Leu Arg  Lys Leu Arg 
    1370                 1375                 1380             


Ser Leu  Ala Ile Met Arg Asp  Gly Val Thr His Trp  Ser Leu Ser 
    1385                 1390                 1395             


Asn Ser  Trp Asp Val Asp Lys  Gly Thr Phe Leu Ser  Phe Ser Asp 
    1400                 1405                 1410             


Arg Val  Ser Gln Ser Val Val  Ser Ala Glu Val Glu  Met Thr Ala 
    1415                 1420                 1425             


Tyr Ala  Leu Leu Thr Tyr Thr  Leu Leu Gly Asp Val  Ala Ala Ala 
    1430                 1435                 1440             


Leu Pro  Val Val Lys Trp Leu  Ser Gln Gln Arg Asn  Ala Leu Gly 
    1445                 1450                 1455             


Gly Phe  Ser Ser Thr Gln Asp  Thr Cys Val Ala Leu  Gln Ala Leu 
    1460                 1465                 1470             


Ala Glu  Tyr Ala Ile Leu Ser  Tyr Ala Gly Gly Ile  Asn Leu Thr 
    1475                 1480                 1485             


Val Ser  Leu Ala Ser Thr Asn  Leu Asp Tyr Gln Glu  Thr Phe Glu 
    1490                 1495                 1500             


Leu His  Arg Thr Asn Gln Lys  Val Leu Gln Thr Ala  Ala Ile Pro 
    1505                 1510                 1515             


Ser Leu  Pro Thr Gly Leu Phe  Val Ser Ala Lys Gly  Asp Gly Cys 
    1520                 1525                 1530             


Cys Leu  Met Gln Ile Asp Val  Thr Tyr Asn Val Pro  Asp Pro Val 
    1535                 1540                 1545             


Ala Lys  Pro Ala Phe Gln Leu  Leu Val Ser Leu Gln  Glu Pro Glu 
    1550                 1555                 1560             


Ala Gln  Gly Arg Pro Pro Pro  Met Pro Ala Ser Ala  Ala Glu Gly 
    1565                 1570                 1575             


Ser Arg  Gly Asp Trp Pro Pro  Ala Asp Asp Asp Asp  Pro Ala Ala 
    1580                 1585                 1590             


Asp Gln  His His Gln Glu Tyr  Lys Val Met Leu Glu  Val Cys Thr 
    1595                 1600                 1605             


Arg Trp  Leu His Ala Gly Ser  Ser Asn Met Ala Val  Leu Glu Val 
    1610                 1615                 1620             


Pro Leu  Leu Ser Gly Phe Arg  Ala Asp Ile Glu Ser  Leu Glu Gln 
    1625                 1630                 1635             


Leu Leu  Leu Asp Lys His Met  Gly Met Lys Arg Tyr  Glu Val Ala 
    1640                 1645                 1650             


Gly Arg  Arg Val Leu Phe Tyr  Phe Asp Glu Ile Pro  Ser Arg Cys 
    1655                 1660                 1665             


Leu Thr  Cys Val Arg Phe Arg  Ala Leu Arg Glu Cys  Val Val Gly 
    1670                 1675                 1680             


Arg Thr  Ser Ala Leu Pro Val  Ser Val Tyr Asp Tyr  Tyr Glu Pro 
    1685                 1690                 1695             


Ala Phe  Glu Ala Thr Arg Phe  Tyr Asn Val Ser Thr  His Ser Pro 
    1700                 1705                 1710             


Leu Ala  Arg Glu Leu Cys Ala  Gly Pro Ala Cys Asn  Glu Val Glu 
    1715                 1720                 1725             


Arg Ala  Pro Ala Arg Gly Pro  Gly Trp Phe Pro Gly  Glu Ser Gly 
    1730                 1735                 1740             


Pro Ala  Val Ala Pro Glu Glu  Gly Ala Ala Ile Ala  Arg Cys Gly 
    1745                 1750                 1755             


Cys Asp  His Asp Cys Gly Ala  Gln Gly Asn Pro Val  Cys Gly Ser 
    1760                 1765                 1770             


Asp Gly  Val Val Tyr Ala Ser  Ala Cys Arg Leu Arg  Glu Ala Ala 
    1775                 1780                 1785             


Cys Arg  Gln Ala Ala Pro Leu  Glu Pro Ala Pro Pro  Ser Cys Cys 
    1790                 1795                 1800             


Ala Leu  Glu Gln Arg Leu Pro  Ala Ser Ser Ser Ser  Thr Tyr Gly 
    1805                 1810                 1815             


Asp Asp  Leu Ala Ser Val Ala  Pro Gly Pro Leu Gln  Gln Asp Val 
    1820                 1825                 1830             


Lys Leu  Asn Gly Ala Gly Leu  Glu Val Glu Asp Ser  Asp Pro Glu 
    1835                 1840                 1845             


Pro Glu  Gly Glu Ala Glu Asp  Arg Val Thr Ala Gly  Pro Arg Pro 
    1850                 1855                 1860             


Pro Val  Ser Ser Gly Asn Leu  Glu Ser Ser Thr Gln  Ser Ala Ser 
    1865                 1870                 1875             


Pro Phe  His Arg Trp Gly Gln  Thr Pro Ala Pro Gln  Arg His Ser 
    1880                 1885                 1890             


Gly Arg  Val Val Gly Ala His  Arg Pro Gly Leu Leu  Ser Pro Val 
    1895                 1900                 1905             


Phe Val  Tyr Ser Pro Ala Phe  Gln Ser Gly Gly Glu  Glu Gly Leu 
    1910                 1915                 1920             


Trp Met  Ser Asn Thr Cys Thr  Leu Arg 
    1925                 1930         


<210>  3428
<211>  503
<212>  PRT
<213>  Homo Sapiens

<400>  3428

Met Ser Gly Ala Leu Leu Trp Pro Leu Leu Pro Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ser Ala Arg Asp Gly Val Arg Ala Ala Gln Pro Gln Ala Pro Gly 
            20                  25                  30          


Tyr Leu Ile Ala Ala Pro Ser Val Phe Arg Ala Gly Val Glu Glu Val 
        35                  40                  45              


Ile Ser Val Thr Ile Phe Asn Ser Pro Arg Glu Val Thr Val Gln Ala 
    50                  55                  60                  


Gln Leu Val Ala Gln Gly Glu Pro Val Val Gln Ser Gln Gly Ala Ile 
65                  70                  75                  80  


Leu Asp Lys Gly Thr Ile Lys Leu Lys Val Pro Thr Gly Leu Arg Gly 
                85                  90                  95      


Gln Ala Leu Leu Lys Val Trp Gly Arg Gly Trp Gln Ala Glu Glu Gly 
            100                 105                 110         


Pro Leu Phe His Asn Gln Thr Ser Val Thr Val Asp Gly Arg Gly Ala 
        115                 120                 125             


Ser Val Phe Ile Gln Thr Asp Lys Pro Val Tyr Arg Pro Gln His Arg 
    130                 135                 140                 


Val Leu Ile Ser Ile Phe Thr Val Ser Pro Asn Leu Arg Pro Val Asn 
145                 150                 155                 160 


Glu Lys Leu Glu Ala Tyr Ile Leu Asp Pro Arg Gly Ser Arg Met Ile 
                165                 170                 175     


Glu Trp Arg His Leu Lys Pro Phe Cys Cys Gly Ile Thr Asn Met Ser 
            180                 185                 190         


Phe Pro Leu Ser Asp Gln Pro Val Leu Gly Glu Trp Phe Ile Phe Val 
        195                 200                 205             


Glu Met Gln Gly His Ala Tyr Asn Lys Ser Phe Glu Val Gln Lys Tyr 
    210                 215                 220                 


Val Leu Pro Lys Phe Glu Leu Leu Ile Asp Pro Pro Arg Tyr Ile Gln 
225                 230                 235                 240 


Asp Leu Asp Ala Cys Glu Thr Gly Thr Val Arg Ala Arg Tyr Thr Phe 
                245                 250                 255     


Gly Lys Pro Val Ala Gly Ala Leu Met Ile Asn Met Thr Val Asn Gly 
            260                 265                 270         


Val Gly Tyr Tyr Ser His Glu Val Gly Arg Pro Val Leu Arg Thr Thr 
        275                 280                 285             


Lys Ile Leu Gly Ser Arg Asp Phe Asp Ile Cys Val Arg Asp Met Ile 
    290                 295                 300                 


Pro Ala Asp Val Pro Glu His Phe Arg Gly Arg Val Ser Ile Trp Ala 
305                 310                 315                 320 


Met Val Thr Ser Val Asp Gly Ser Gln Gln Val Ala Phe Asp Asp Ser 
                325                 330                 335     


Thr Pro Val Gln Arg Gln Leu Val Asp Ile Arg Tyr Ser Lys Asp Thr 
            340                 345                 350         


Arg Lys Gln Phe Lys Pro Gly Leu Ala Tyr Val Gly Lys Val Glu Leu 
        355                 360                 365             


Ser Tyr Pro Asp Gly Ser Pro Ala Glu Gly Val Thr Val Gln Ile Lys 
    370                 375                 380                 


Ala Glu Leu Thr Pro Lys Asp Asn Ile Tyr Thr Ser Glu Val Val Ser 
385                 390                 395                 400 


Gln Arg Gly Leu Val Gly Phe Glu Ile Pro Ser Ile Pro Thr Ser Ala 
                405                 410                 415     


Gln His Val Trp Leu Glu Val Phe Gln Glu Leu Glu Asp Tyr Asp Val 
            420                 425                 430         


Ser Asp Ser Phe Gly Val Ser Arg Glu Asp Gly Pro Phe Trp Trp Ala 
        435                 440                 445             


Gly Leu Thr Ala Gln Arg Arg Arg Arg Ser Ser Val Phe Pro Trp Pro 
    450                 455                 460                 


Trp Gly Ile Thr Lys Asp Ser Gly Phe Ala Phe Thr Val Arg Arg Gly 
465                 470                 475                 480 


Asn Gly Thr Gly Gly Asp Asp Arg Pro Ser Glu Pro Glu Pro Pro Ala 
                485                 490                 495     


Gly Arg Trp Pro Leu His Arg 
            500             


<210>  3429
<211>  56
<212>  PRT
<213>  Homo Sapiens

<400>  3429

Arg Thr Gln Thr Leu Ser Leu Lys Gly Arg Arg Arg Thr Glu Arg Leu 
1               5                   10                  15      


Leu Phe Leu Thr Ala Ala Leu Leu Arg Ala Gly Arg His His Leu Ala 
            20                  25                  30          


Ala Ser Cys Pro Tyr Gln Pro Val Thr Leu Tyr Gly Gly Trp Ala Asp 
        35                  40                  45              


Leu Ser Pro Gly Asp Thr Cys Leu 
    50                  55      


<210>  3430
<211>  338
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3430

Xaa Val Ser Ala Lys Gly Asp Gly Cys Cys Leu Met Gln Ile Asp Val 
1               5                   10                  15      


Thr Tyr Asn Val Pro Asp Pro Val Ala Lys Pro Ala Phe Gln Leu Leu 
            20                  25                  30          


Val Ser Leu Gln Glu Pro Glu Ala Gln Gly Arg Pro Pro Pro Met Pro 
        35                  40                  45              


Ala Ser Ala Ala Glu Gly Ser Arg Gly Asp Trp Pro Pro Ala Asp Asp 
    50                  55                  60                  


Asp Asp Pro Ala Ala Asp Gln His His Gln Glu Tyr Lys Val Met Leu 
65                  70                  75                  80  


Glu Val Cys Thr Arg Trp Leu His Ala Gly Ser Ser Asn Met Ala Val 
                85                  90                  95      


Leu Glu Val Pro Leu Leu Ser Gly Phe Arg Ala Asp Ile Glu Ser Leu 
            100                 105                 110         


Glu Gln Leu Leu Leu Asp Lys His Met Gly Met Lys Arg Tyr Glu Val 
        115                 120                 125             


Ala Gly Arg Arg Val Leu Phe Tyr Phe Asp Glu Ile Pro Ser Arg Cys 
    130                 135                 140                 


Leu Thr Cys Val Arg Phe Arg Ala Leu Arg Glu Cys Val Val Gly Arg 
145                 150                 155                 160 


Thr Ser Ala Leu Pro Val Ser Val Tyr Asp Tyr Tyr Glu Pro Ala Phe 
                165                 170                 175     


Glu Ala Thr Arg Phe Tyr Asn Val Ser Thr His Ser Pro Leu Ala Arg 
            180                 185                 190         


Glu Leu Cys Ala Gly Pro Ala Cys Asn Glu Val Glu Arg Ala Pro Ala 
        195                 200                 205             


Arg Gly Pro Gly Trp Phe Pro Gly Glu Ser Gly Pro Ala Val Ala Pro 
    210                 215                 220                 


Glu Glu Gly Ala Ala Ile Ala Arg Cys Gly Cys Asp His Asp Cys Gly 
225                 230                 235                 240 


Ala Gln Gly Asn Pro Val Cys Gly Ser Asp Gly Val Val Tyr Ala Ser 
                245                 250                 255     


Ala Cys Arg Leu Arg Glu Ala Ala Cys Arg Gln Ala Ala Pro Leu Glu 
            260                 265                 270         


Pro Ala Pro Pro Ser Cys Cys Ala Leu Glu Gln Arg Leu Pro Ala Ser 
        275                 280                 285             


Ser Ser Ser Thr Tyr Gly Asp Asp Leu Ala Ser Val Ala Pro Gly Pro 
    290                 295                 300                 


Leu Gln Gln Asp Val Lys Leu Asn Gly Ala Gly Leu Glu Val Glu Asp 
305                 310                 315                 320 


Ser Asp Pro Glu Pro Glu Gly Glu Ala Glu Asp Ser Gln Ser Gly Phe 
                325                 330                 335     


Ser Ser 
        


<210>  3431
<211>  59
<212>  PRT
<213>  Homo Sapiens

<400>  3431

Met Leu Ala Leu Leu Val Leu Val Thr Val Ala Leu Ala Ser Ala His 
1               5                   10                  15      


His Gly Gly Glu His Phe Glu Gly Glu Lys Val Phe Arg Val Asn Val 
            20                  25                  30          


Glu Asp Glu Asn His Ile Asn Ile Ile Arg Glu Leu Ala Ser Thr Thr 
        35                  40                  45              


Gln Ile Asp Phe Trp Lys Pro Asp Ser Val Thr 
    50                  55                  


<210>  3432
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  3432

Met Leu Ala Leu Leu Val Leu Val Thr Val Ala Leu Ala Ser Ala His 
1               5                   10                  15      


His Gly Gly Glu His Phe Glu Gly Glu Lys Val Phe Arg Val Asn Val 
            20                  25                  30          


Glu Asp Glu Asn His Ile Asn Ile Ile Arg Glu Leu Ala Ser Thr Thr 
        35                  40                  45              


Gln Ile Asp Phe Trp Lys Pro Asp Ser Val Thr Gln Ile Lys Pro His 
    50                  55                  60                  


Ser Thr Val Asp Phe Arg Val Lys Ala Glu Asp Thr Val Thr Val Glu 
65                  70                  75                  80  


Asn Val Leu Lys Gln Asn Glu Leu Gln Tyr Lys Val Leu Ile Ser Asn 
                85                  90                  95      


Leu Arg Asn 
            


<210>  3433
<211>  417
<212>  PRT
<213>  Homo Sapiens

<400>  3433

Met Leu Ala Leu Leu Val Leu Val Thr Val Ala Leu Ala Ser Ala His 
1               5                   10                  15      


His Gly Gly Glu His Phe Glu Gly Glu Lys Val Phe Arg Val Asn Val 
            20                  25                  30          


Glu Asp Glu Asn His Ile Asn Ile Ile Arg Glu Leu Ala Ser Thr Thr 
        35                  40                  45              


Gln Ile Asp Phe Trp Lys Pro Asp Ser Val Thr Gln Ile Lys Pro His 
    50                  55                  60                  


Ser Thr Val Asp Phe Arg Val Lys Ala Glu Asp Thr Val Thr Val Glu 
65                  70                  75                  80  


Asn Val Leu Lys Gln Asn Glu Leu Gln Tyr Lys Val Leu Ile Ser Asn 
                85                  90                  95      


Leu Arg Asn Val Val Glu Ala Gln Phe Asp Ser Arg Val Arg Ala Thr 
            100                 105                 110         


Gly His Ser Tyr Glu Lys Tyr Asn Lys Trp Glu Thr Ile Glu Ala Trp 
        115                 120                 125             


Thr Gln Gln Val Ala Thr Glu Asn Pro Ala Leu Ile Ser Arg Ser Val 
    130                 135                 140                 


Ile Gly Thr Thr Phe Glu Gly Arg Ala Ile Tyr Leu Leu Lys Val Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Asn Lys Pro Ala Ile Phe Met Asp Cys Gly Phe His 
                165                 170                 175     


Ala Arg Glu Trp Ile Ser Pro Ala Phe Cys Gln Trp Phe Val Arg Glu 
            180                 185                 190         


Ala Val Arg Thr Tyr Gly Arg Glu Ile Gln Val Thr Glu Leu Leu Asp 
        195                 200                 205             


Lys Leu Asp Phe Tyr Val Leu Pro Val Leu Asn Ile Asp Gly Tyr Ile 
    210                 215                 220                 


Tyr Thr Trp Thr Lys Ser Arg Phe Trp Arg Lys Thr Arg Ser Thr His 
225                 230                 235                 240 


Thr Gly Ser Ser Cys Ile Gly Thr Asp Pro Asn Arg Asn Phe Asp Ala 
                245                 250                 255     


Gly Trp Cys Glu Ile Gly Ala Ser Arg Asn Pro Cys Asp Glu Thr Tyr 
            260                 265                 270         


Cys Gly Pro Ala Ala Glu Ser Glu Lys Glu Thr Lys Ala Leu Ala Asp 
        275                 280                 285             


Phe Ile Arg Asn Lys Leu Ser Ser Ile Lys Ala Tyr Leu Thr Ile His 
    290                 295                 300                 


Ser Tyr Ser Gln Met Met Ile Tyr Pro Tyr Ser Tyr Ala Tyr Lys Leu 
305                 310                 315                 320 


Gly Glu Asn Asn Ala Glu Leu Asn Ala Leu Ala Lys Ala Thr Val Lys 
                325                 330                 335     


Glu Leu Ala Ser Leu His Gly Thr Lys Tyr Thr Tyr Gly Pro Gly Ala 
            340                 345                 350         


Thr Thr Ile Tyr Pro Ala Ala Gly Gly Ser Asp Asp Trp Ala Tyr Asp 
        355                 360                 365             


Gln Gly Ile Arg Tyr Ser Phe Thr Phe Glu Leu Arg Asp Thr Gly Arg 
    370                 375                 380                 


Tyr Gly Phe Leu Leu Pro Glu Ser Gln Ile Arg Ala Thr Cys Glu Glu 
385                 390                 395                 400 


Thr Phe Leu Ala Ile Lys Tyr Val Ala Ser Tyr Val Leu Glu His Leu 
                405                 410                 415     


Tyr 
    


<210>  3434
<211>  417
<212>  PRT
<213>  Homo Sapiens

<400>  3434

Met Leu Ala Leu Leu Val Leu Val Thr Val Ala Leu Ala Ser Ala His 
1               5                   10                  15      


His Gly Gly Glu His Phe Glu Gly Glu Lys Val Phe Arg Val Asn Val 
            20                  25                  30          


Glu Asp Glu Asn His Ile Asn Ile Ile Arg Glu Leu Ala Ser Thr Thr 
        35                  40                  45              


Gln Ile Asp Phe Trp Lys Pro Asp Ser Val Thr Gln Ile Lys Pro His 
    50                  55                  60                  


Ser Thr Val Asp Phe Arg Val Lys Ala Glu Asp Thr Val Thr Val Glu 
65                  70                  75                  80  


Asn Val Leu Lys Gln Asn Glu Leu Gln Tyr Lys Val Leu Ile Ser Asn 
                85                  90                  95      


Leu Arg Asn Val Val Glu Ala Gln Phe Asp Ser Arg Val Arg Ala Thr 
            100                 105                 110         


Gly His Ser Tyr Glu Lys Tyr Asn Lys Trp Glu Thr Ile Glu Ala Trp 
        115                 120                 125             


Thr Gln Gln Val Ala Thr Glu Asn Pro Ala Leu Ile Ser Arg Ser Val 
    130                 135                 140                 


Ile Gly Thr Thr Phe Glu Gly Arg Ala Ile Tyr Leu Leu Lys Val Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Asn Lys Pro Ala Ile Phe Met Asp Cys Gly Phe His 
                165                 170                 175     


Ala Arg Glu Trp Ile Ser Pro Ala Phe Cys Gln Trp Phe Val Arg Glu 
            180                 185                 190         


Ala Val Arg Thr Tyr Gly Arg Glu Ile Gln Val Thr Glu Leu Leu Asp 
        195                 200                 205             


Lys Leu Asp Phe Tyr Val Leu Pro Val Leu Asn Ile Asp Gly Tyr Ile 
    210                 215                 220                 


Tyr Thr Trp Thr Lys Ser Arg Phe Trp Arg Lys Thr Arg Ser Thr His 
225                 230                 235                 240 


Thr Gly Ser Ser Cys Ile Gly Thr Asp Pro Asn Arg Asn Phe Asp Ala 
                245                 250                 255     


Gly Trp Cys Glu Ile Gly Ala Ser Arg Asn Pro Cys Asp Glu Thr Tyr 
            260                 265                 270         


Cys Gly Pro Ala Ala Glu Ser Glu Lys Glu Thr Lys Ala Leu Ala Asp 
        275                 280                 285             


Phe Ile Arg Asn Lys Leu Ser Ser Ile Lys Ala Tyr Leu Thr Ile His 
    290                 295                 300                 


Ser Tyr Ser Gln Met Met Ile Tyr Pro Tyr Ser Tyr Ala Tyr Lys Leu 
305                 310                 315                 320 


Gly Glu Asn Asn Ala Glu Leu Asn Ala Leu Ala Lys Ala Thr Val Lys 
                325                 330                 335     


Glu Leu Ala Ser Leu His Gly Thr Lys Tyr Thr Tyr Gly Pro Gly Ala 
            340                 345                 350         


Thr Thr Ile Tyr Pro Ala Ala Gly Gly Ser Asp Asp Trp Ala Tyr Asp 
        355                 360                 365             


Gln Gly Ile Arg Tyr Ser Phe Thr Phe Glu Leu Arg Asp Thr Gly Arg 
    370                 375                 380                 


Tyr Gly Phe Leu Leu Pro Glu Ser Gln Ile Arg Ala Thr Cys Glu Glu 
385                 390                 395                 400 


Thr Phe Leu Ala Ile Lys Tyr Val Ala Ser Tyr Val Leu Glu His Leu 
                405                 410                 415     


Tyr 
    


<210>  3435
<211>  203
<212>  PRT
<213>  Homo Sapiens

<400>  3435

Met Leu Ala Leu Leu Val Leu Val Thr Val Ala Leu Ala Ser Ala His 
1               5                   10                  15      


His Gly Gly Glu His Phe Glu Gly Glu Lys Val Phe Arg Val Asn Val 
            20                  25                  30          


Glu Asp Glu Asn His Ile Asn Ile Ile Arg Glu Leu Ala Ser Thr Thr 
        35                  40                  45              


Gln Ile Asp Phe Trp Lys Pro Asp Ser Val Thr Gln Ile Lys Pro His 
    50                  55                  60                  


Ser Thr Val Asp Phe Arg Val Lys Ala Glu Asp Thr Val Thr Val Glu 
65                  70                  75                  80  


Asn Val Leu Lys Gln Asn Glu Leu Gln Tyr Lys Val Leu Ile Ser Asn 
                85                  90                  95      


Leu Arg Asn Val Val Glu Ala Gln Phe Asp Ser Arg Val Arg Ala Thr 
            100                 105                 110         


Gly His Ser Tyr Glu Lys Tyr Asn Lys Trp Glu Thr Val Gly Lys Ala 
        115                 120                 125             


Gly Gln Asn Lys Pro Ala Ile Phe Met Asp Cys Gly Phe His Ala Arg 
    130                 135                 140                 


Glu Trp Ile Ser Pro Ala Phe Cys Gln Trp Phe Val Arg Glu Ala Val 
145                 150                 155                 160 


Arg Thr Tyr Gly Arg Glu Ile Gln Val Thr Glu Leu Leu Asp Lys Leu 
                165                 170                 175     


Asp Phe Tyr Val Leu Pro Val Leu Asn Ile Asp Gly Tyr Ile Tyr Thr 
            180                 185                 190         


Trp Thr Lys Ser Arg Phe Trp Arg Lys Thr Arg 
        195                 200             


<210>  3436
<211>  423
<212>  PRT
<213>  Homo Sapiens

<400>  3436

Met Lys Leu Cys Ser Leu Ala Val Leu Val Pro Ile Val Leu Phe Cys 
1               5                   10                  15      


Glu Gln His Val Phe Ala Phe Gln Ser Gly Gln Val Leu Ala Ala Leu 
            20                  25                  30          


Pro Arg Thr Ser Arg Gln Val Gln Val Leu Gln Asn Leu Thr Thr Thr 
        35                  40                  45              


Tyr Glu Ile Val Leu Trp Gln Pro Val Thr Ala Asp Leu Ile Val Lys 
    50                  55                  60                  


Lys Lys Gln Val His Phe Phe Val Asn Ala Ser Asp Val Asp Asn Val 
65                  70                  75                  80  


Lys Ala His Leu Asn Val Ser Gly Ile Pro Cys Ser Val Leu Leu Ala 
                85                  90                  95      


Asp Val Glu Asp Leu Ile Gln Gln Gln Ile Ser Asn Asp Thr Val Ser 
            100                 105                 110         


Pro Arg Ala Ser Ala Ser Tyr Tyr Glu Gln Tyr His Ser Leu Asn Glu 
        115                 120                 125             


Ile Tyr Ser Trp Ile Glu Phe Ile Thr Glu Arg His Pro Asp Met Leu 
    130                 135                 140                 


Thr Lys Ile His Ile Gly Ser Ser Phe Glu Lys Tyr Pro Leu Tyr Val 
145                 150                 155                 160 


Leu Lys Val Ser Gly Lys Glu Gln Ala Ala Lys Asn Ala Ile Trp Ile 
                165                 170                 175     


Asp Cys Gly Ile His Ala Arg Glu Trp Ile Ser Pro Ala Phe Cys Leu 
            180                 185                 190         


Trp Phe Ile Gly His Ile Thr Gln Phe Tyr Gly Ile Ile Gly Gln Tyr 
        195                 200                 205             


Thr Asn Leu Leu Arg Leu Val Asp Phe Tyr Val Met Pro Val Val Asn 
    210                 215                 220                 


Val Asp Gly Tyr Asp Tyr Ser Trp Lys Lys Asn Arg Met Trp Arg Lys 
225                 230                 235                 240 


Asn Arg Ser Phe Tyr Ala Asn Asn His Cys Ile Gly Thr Asp Leu Asn 
                245                 250                 255     


Arg Asn Phe Ala Ser Lys His Trp Cys Glu Glu Gly Ala Ser Ser Ser 
            260                 265                 270         


Ser Cys Ser Glu Thr Tyr Cys Gly Leu Tyr Pro Glu Ser Glu Pro Glu 
        275                 280                 285             


Val Lys Ala Val Ala Ser Phe Leu Arg Arg Asn Ile Asn Gln Ile Lys 
    290                 295                 300                 


Ala Tyr Ile Ser Met His Ser Tyr Ser Gln His Ile Val Phe Pro Tyr 
305                 310                 315                 320 


Ser Tyr Thr Arg Ser Lys Ser Lys Asp His Glu Glu Leu Ser Leu Val 
                325                 330                 335     


Ala Ser Glu Ala Val Arg Ala Ile Glu Lys Ile Ser Lys Asn Thr Arg 
            340                 345                 350         


Tyr Thr His Gly His Gly Ser Glu Thr Leu Tyr Leu Ala Pro Gly Gly 
        355                 360                 365             


Gly Asp Asp Trp Ile Tyr Asp Leu Gly Ile Lys Tyr Ser Phe Thr Ile 
    370                 375                 380                 


Glu Leu Arg Asp Thr Gly Thr Tyr Gly Phe Leu Leu Pro Glu Arg Tyr 
385                 390                 395                 400 


Ile Lys Pro Thr Cys Arg Glu Ala Phe Ala Ala Val Ser Lys Ile Ala 
                405                 410                 415     


Trp His Val Ile Arg Asn Val 
            420             


<210>  3437
<211>  423
<212>  PRT
<213>  Homo Sapiens

<400>  3437

Met Lys Leu Cys Ser Leu Ala Val Leu Val Pro Ile Val Leu Phe Cys 
1               5                   10                  15      


Glu Gln His Val Phe Ala Phe Gln Ser Gly Gln Val Leu Ala Ala Leu 
            20                  25                  30          


Pro Arg Thr Ser Arg Gln Val Gln Val Leu Gln Asn Leu Thr Thr Thr 
        35                  40                  45              


Tyr Glu Ile Val Leu Trp Gln Pro Val Thr Ala Asp Leu Ile Val Lys 
    50                  55                  60                  


Lys Lys Gln Val His Phe Phe Val Asn Ala Ser Asp Val Asp Asn Val 
65                  70                  75                  80  


Lys Ala His Leu Asn Val Ser Gly Ile Pro Cys Ser Val Leu Leu Ala 
                85                  90                  95      


Asp Val Glu Asp Leu Ile Gln Gln Gln Ile Ser Asn Asp Thr Val Ser 
            100                 105                 110         


Pro Arg Ala Ser Ala Ser Tyr Tyr Glu Gln Tyr His Ser Leu Asn Glu 
        115                 120                 125             


Ile Tyr Ser Trp Ile Glu Phe Ile Thr Glu Arg His Pro Asp Met Leu 
    130                 135                 140                 


Thr Lys Ile His Ile Gly Ser Ser Phe Glu Lys Tyr Pro Leu Tyr Val 
145                 150                 155                 160 


Leu Lys Val Ser Gly Lys Glu Gln Ala Ala Lys Asn Ala Ile Trp Ile 
                165                 170                 175     


Asp Cys Gly Ile His Ala Arg Glu Trp Ile Ser Pro Ala Phe Cys Leu 
            180                 185                 190         


Trp Phe Ile Gly His Ile Thr Gln Phe Tyr Gly Ile Ile Gly Gln Tyr 
        195                 200                 205             


Thr Asn Leu Leu Arg Leu Val Asp Phe Tyr Val Met Pro Val Val Asn 
    210                 215                 220                 


Val Asp Gly Tyr Asp Tyr Ser Trp Lys Lys Asn Arg Met Trp Arg Lys 
225                 230                 235                 240 


Asn Arg Ser Phe Tyr Ala Asn Asn His Cys Ile Gly Thr Asp Leu Asn 
                245                 250                 255     


Arg Asn Phe Ala Ser Lys His Trp Cys Glu Glu Gly Ala Ser Ser Ser 
            260                 265                 270         


Ser Cys Ser Glu Thr Tyr Cys Gly Leu Tyr Pro Glu Ser Glu Pro Glu 
        275                 280                 285             


Val Lys Ala Val Ala Ser Phe Leu Arg Arg Asn Ile Asn Gln Ile Lys 
    290                 295                 300                 


Ala Tyr Ile Ser Met His Ser Tyr Ser Gln His Ile Val Phe Pro Tyr 
305                 310                 315                 320 


Ser Tyr Thr Arg Ser Lys Ser Lys Asp His Glu Glu Leu Ser Leu Val 
                325                 330                 335     


Ala Ser Glu Ala Val Arg Ala Ile Glu Lys Ile Ser Lys Asn Thr Arg 
            340                 345                 350         


Tyr Thr His Gly His Gly Ser Glu Thr Leu Tyr Leu Ala Pro Gly Gly 
        355                 360                 365             


Gly Asp Asp Trp Ile Tyr Asp Leu Gly Ile Lys Tyr Ser Phe Thr Ile 
    370                 375                 380                 


Glu Leu Arg Asp Thr Gly Thr Tyr Gly Phe Leu Leu Pro Glu Arg Tyr 
385                 390                 395                 400 


Ile Lys Pro Thr Cys Arg Glu Ala Phe Ala Ala Val Ser Lys Ile Ala 
                405                 410                 415     


Trp His Val Ile Arg Asn Val 
            420             


<210>  3438
<211>  386
<212>  PRT
<213>  Homo Sapiens

<400>  3438

Met Lys Leu Cys Ser Leu Ala Val Leu Val Pro Ile Val Leu Phe Cys 
1               5                   10                  15      


Glu Gln His Val Phe Ala Phe Gln Ser Gly Gln Val Leu Ala Ala Leu 
            20                  25                  30          


Pro Arg Thr Ser Arg Gln Val Gln Val Leu Gln Asn Leu Thr Thr Thr 
        35                  40                  45              


Tyr Glu Ile Val Leu Trp Gln Pro Val Thr Ala Asp Leu Ile Val Lys 
    50                  55                  60                  


Lys Lys Gln Val His Phe Phe Val Asn Ala Ser Asp Val Asp Asn Val 
65                  70                  75                  80  


Lys Ala His Leu Asn Val Ser Gly Ile Pro Cys Ser Val Leu Leu Ala 
                85                  90                  95      


Asp Val Glu Asp Leu Ile Gln Gln Gln Ile Ser Asn Asp Thr Val Ser 
            100                 105                 110         


Pro Arg Ala Ser Ala Ser Tyr Tyr Glu Gln Tyr His Ser Leu Asn Glu 
        115                 120                 125             


Ile Tyr Ser Trp Ile Glu Phe Ile Thr Glu Arg His Pro Asp Met Leu 
    130                 135                 140                 


Thr Lys Ile His Ile Gly Ser Ser Phe Glu Lys Tyr Pro Leu Tyr Val 
145                 150                 155                 160 


Leu Lys Val Ser Gly Lys Glu Gln Ala Ala Lys Asn Ala Ile Trp Ile 
                165                 170                 175     


Asp Cys Gly Ile His Ala Arg Glu Trp Ile Ser Pro Ala Phe Cys Leu 
            180                 185                 190         


Trp Phe Ile Gly His Asn Arg Met Trp Arg Lys Asn Arg Ser Phe Tyr 
        195                 200                 205             


Ala Asn Asn His Cys Ile Gly Thr Asp Leu Asn Arg Asn Phe Ala Ser 
    210                 215                 220                 


Lys His Trp Cys Glu Glu Gly Ala Ser Ser Ser Ser Cys Ser Glu Thr 
225                 230                 235                 240 


Tyr Cys Gly Leu Tyr Pro Glu Ser Glu Pro Glu Val Lys Ala Val Ala 
                245                 250                 255     


Ser Phe Leu Arg Arg Asn Ile Asn Gln Ile Lys Ala Tyr Ile Ser Met 
            260                 265                 270         


His Ser Tyr Ser Gln His Ile Val Phe Pro Tyr Ser Tyr Thr Arg Ser 
        275                 280                 285             


Lys Ser Lys Asp His Glu Glu Leu Ser Leu Val Ala Ser Glu Ala Val 
    290                 295                 300                 


Arg Ala Ile Glu Lys Ile Ser Lys Asn Thr Arg Tyr Thr His Gly His 
305                 310                 315                 320 


Gly Ser Glu Thr Leu Tyr Leu Ala Pro Gly Gly Gly Asp Asp Trp Ile 
                325                 330                 335     


Tyr Asp Leu Gly Ile Lys Tyr Ser Phe Thr Ile Glu Leu Arg Asp Thr 
            340                 345                 350         


Gly Thr Tyr Gly Phe Leu Leu Pro Glu Arg Tyr Ile Lys Pro Thr Cys 
        355                 360                 365             


Arg Glu Ala Phe Ala Ala Val Ser Lys Ile Ala Trp His Val Ile Arg 
    370                 375                 380                 


Asn Val 
385     


<210>  3439
<211>  476
<212>  PRT
<213>  Homo Sapiens

<400>  3439

Met Ala Gly Arg Gly Gly Ser Ala Leu Leu Ala Leu Cys Gly Ala Leu 
1               5                   10                  15      


Ala Ala Cys Gly Trp Leu Leu Gly Ala Glu Ala Gln Glu Pro Gly Ala 
            20                  25                  30          


Pro Ala Ala Gly Met Arg Arg Arg Arg Arg Leu Gln Gln Glu Asp Gly 
        35                  40                  45              


Ile Ser Phe Glu Tyr His Arg Tyr Pro Glu Leu Arg Glu Ala Leu Val 
    50                  55                  60                  


Ser Val Trp Leu Gln Cys Thr Ala Ile Ser Arg Ile Tyr Thr Val Gly 
65                  70                  75                  80  


Arg Ser Phe Glu Gly Arg Glu Leu Leu Val Ile Glu Leu Ser Asp Asn 
                85                  90                  95      


Pro Gly Val His Glu Pro Gly Glu Pro Glu Phe Lys Tyr Ile Gly Asn 
            100                 105                 110         


Met His Gly Asn Glu Ala Val Gly Arg Glu Leu Leu Ile Phe Leu Ala 
        115                 120                 125             


Gln Tyr Leu Cys Asn Glu Tyr Gln Lys Gly Asn Glu Thr Ile Val Asn 
    130                 135                 140                 


Leu Ile His Ser Thr Arg Ile His Ile Met Pro Ser Leu Asn Pro Asp 
145                 150                 155                 160 


Gly Phe Glu Lys Ala Ala Ser Gln Pro Gly Glu Leu Lys Asp Trp Phe 
                165                 170                 175     


Val Gly Arg Ser Asn Ala Gln Gly Ile Asp Leu Asn Arg Asn Phe Pro 
            180                 185                 190         


Asp Leu Asp Arg Ile Val Tyr Val Asn Glu Lys Glu Gly Gly Pro Asn 
        195                 200                 205             


Asn His Leu Leu Lys Asn Met Lys Lys Ile Val Asp Gln Asn Thr Lys 
    210                 215                 220                 


Leu Ala Pro Glu Thr Lys Ala Val Ile His Trp Ile Met Asp Ile Pro 
225                 230                 235                 240 


Phe Val Leu Ser Ala Asn Leu His Gly Gly Asp Leu Val Ala Asn Tyr 
                245                 250                 255     


Pro Tyr Asp Glu Thr Arg Ser Gly Ser Ala His Glu Tyr Ser Ser Ser 
            260                 265                 270         


Pro Asp Asp Ala Ile Phe Gln Ser Leu Ala Arg Ala Tyr Ser Ser Phe 
        275                 280                 285             


Asn Pro Ala Met Ser Asp Pro Asn Arg Pro Pro Cys Arg Lys Asn Asp 
    290                 295                 300                 


Asp Asp Ser Ser Phe Val Asp Gly Thr Thr Asn Gly Gly Ala Trp Tyr 
305                 310                 315                 320 


Ser Val Pro Gly Gly Met Gln Asp Phe Asn Tyr Leu Ser Ser Asn Cys 
                325                 330                 335     


Phe Glu Ile Thr Val Glu Leu Ser Cys Glu Lys Phe Pro Pro Glu Glu 
            340                 345                 350         


Thr Leu Lys Thr Tyr Trp Glu Asp Asn Lys Asn Ser Leu Ile Ser Tyr 
        355                 360                 365             


Leu Glu Gln Ile His Arg Gly Val Lys Gly Phe Val Arg Asp Leu Gln 
    370                 375                 380                 


Gly Asn Pro Ile Ala Asn Ala Thr Ile Ser Val Glu Gly Ile Asp His 
385                 390                 395                 400 


Asp Val Thr Ser Ala Lys Asp Gly Asp Tyr Trp Arg Leu Leu Ile Pro 
                405                 410                 415     


Gly Asn Tyr Lys Leu Thr Ala Ser Ala Pro Gly Tyr Leu Ala Ile Thr 
            420                 425                 430         


Lys Lys Val Ala Val Pro Tyr Ser Pro Ala Ala Gly Val Asp Phe Glu 
        435                 440                 445             


Leu Glu Ser Phe Ser Glu Arg Lys Glu Glu Glu Lys Glu Glu Leu Met 
    450                 455                 460                 


Glu Trp Trp Lys Met Met Ser Glu Thr Leu Asn Phe 
465                 470                 475     


<210>  3440
<211>  139
<212>  PRT
<213>  Homo Sapiens

<400>  3440

Met His Gly Asn Glu Ala Val Gly Arg Glu Leu Leu Ile Phe Leu Ala 
1               5                   10                  15      


Gln Tyr Leu Cys Asn Glu Tyr Gln Lys Gly Asn Glu Thr Ile Val Asn 
            20                  25                  30          


Leu Ile His Ser Thr Arg Ile His Ile Met Pro Ser Leu Asn Pro Asp 
        35                  40                  45              


Gly Phe Glu Lys Ala Ala Ser Gln Pro Gly Glu Leu Lys Asp Trp Phe 
    50                  55                  60                  


Val Gly Arg Ser Asn Ala Gln Gly Ile Asp Leu Asn Arg Asn Phe Pro 
65                  70                  75                  80  


Asp Leu Asp Arg Ile Val Tyr Val Asn Glu Lys Glu Gly Gly Pro Asn 
                85                  90                  95      


Asn His Leu Leu Lys Asn Met Lys Lys Ile Val Asp Gln Asn Thr Lys 
            100                 105                 110         


Leu Ala Pro Glu Thr Lys Ala Val Ile His Trp Ile Met Asp Ile Pro 
        115                 120                 125             


Phe Val Leu Ser Ala Asn Leu His Gly Gly Asp 
    130                 135                 


<210>  3441
<211>  147
<212>  PRT
<213>  Homo Sapiens

<400>  3441

Met His Gly Asn Glu Ala Val Gly Arg Glu Leu Leu Ile Phe Leu Ala 
1               5                   10                  15      


Gln Tyr Leu Cys Asn Glu Tyr Gln Lys Gly Asn Glu Thr Ile Val Asn 
            20                  25                  30          


Leu Ile His Ser Thr Arg Ile His Ile Met Pro Ser Leu Asn Pro Asp 
        35                  40                  45              


Gly Phe Glu Lys Ala Ala Ser Gln Pro Gly Glu Leu Lys Asp Trp Phe 
    50                  55                  60                  


Val Gly Arg Ser Asn Ala Gln Gly Ile Asp Leu Asn Arg Asn Phe Pro 
65                  70                  75                  80  


Asp Leu Asp Arg Ile Val Tyr Val Asn Glu Lys Glu Gly Gly Pro Asn 
                85                  90                  95      


Asn His Leu Leu Lys Asn Met Lys Lys Ile Val Asp Gln Asn Thr Lys 
            100                 105                 110         


Leu Ala Pro Glu Thr Lys Ala Val Ile His Trp Ile Met Asp Ile Pro 
        115                 120                 125             


Phe Val Leu Ser Ala Asn Leu His Gly Gly Asp Leu Val Ala Asn Tyr 
    130                 135                 140                 


Pro Tyr Asp 
145         


<210>  3442
<211>  157
<212>  PRT
<213>  Homo Sapiens

<400>  3442

Met His Gly Asn Glu Ala Val Gly Arg Glu Leu Leu Ile Phe Leu Ala 
1               5                   10                  15      


Gln Tyr Leu Cys Asn Glu Tyr Gln Lys Gly Asn Glu Thr Ile Val Asn 
            20                  25                  30          


Leu Ile His Ser Thr Arg Ile His Ile Met Pro Ser Leu Asn Pro Asp 
        35                  40                  45              


Gly Phe Glu Lys Ala Ala Ser Gln Pro Gly Glu Leu Lys Asp Trp Phe 
    50                  55                  60                  


Val Gly Arg Ser Asn Ala Gln Gly Ile Asp Leu Asn Arg Asn Phe Pro 
65                  70                  75                  80  


Asp Leu Asp Arg Ile Val Tyr Val Asn Glu Lys Glu Gly Gly Pro Asn 
                85                  90                  95      


Asn His Leu Leu Lys Asn Met Lys Lys Ile Val Asp Gln Asn Thr Lys 
            100                 105                 110         


Leu Ala Pro Glu Thr Lys Ala Val Ile His Trp Ile Met Asp Ile Pro 
        115                 120                 125             


Phe Val Leu Ser Ala Asn Leu His Gly Gly Asp Leu Val Ala Asn Tyr 
    130                 135                 140                 


Pro Tyr Asp Glu Thr Arg Ser Gly Ser Ala His Glu Tyr 
145                 150                 155         


<210>  3443
<211>  108
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3443

Xaa Leu Gly Ala Glu Ala Gln Glu Pro Gly Ala Pro Ala Ala Gly Met 
1               5                   10                  15      


Arg Arg Arg Arg Arg Leu Gln Gln Glu Asp Gly Ile Ser Phe Glu Tyr 
            20                  25                  30          


His Arg Tyr Pro Glu Leu Arg Glu Ala Leu Val Ser Val Trp Leu Gln 
        35                  40                  45              


Cys Thr Ala Ile Ser Arg Ile Tyr Thr Val Gly Arg Ser Phe Glu Gly 
    50                  55                  60                  


Arg Glu Leu Leu Val Ile Glu Leu Ser Asp Asn Pro Gly Val His Glu 
65                  70                  75                  80  


Pro Asp Cys Lys Leu Tyr Glu Val Gly Thr Leu Ile Pro Ala Pro Ser 
                85                  90                  95      


Ser Cys Leu Ala His Ser Gly Leu Glu Tyr Thr Leu 
            100                 105             


<210>  3444
<211>  64
<212>  PRT
<213>  Homo Sapiens

<400>  3444

Met Asp Phe Pro Cys Leu Trp Leu Gly Leu Leu Leu Pro Leu Val Ala 
1               5                   10                  15      


Ala Leu Asp Phe Asn Tyr His Arg Gln Glu Gly Met Glu Ala Phe Leu 
            20                  25                  30          


Lys Thr Val Ala Gln Asn Tyr Ser Ser Val Thr His Leu His Ser Ile 
        35                  40                  45              


Gly Lys Ser Val Lys Asp Cys Trp Ala Gly Ala Ala Ala Pro Ser Asp 
    50                  55                  60                  


<210>  3445
<211>  64
<212>  PRT
<213>  Homo Sapiens

<400>  3445

Met Asp Phe Pro Cys Leu Trp Leu Gly Leu Leu Leu Pro Leu Val Ala 
1               5                   10                  15      


Ala Leu Asp Phe Asn Tyr His Arg Gln Glu Gly Met Glu Ala Phe Leu 
            20                  25                  30          


Lys Thr Val Ala Gln Asn Tyr Ser Ser Val Thr His Leu His Ser Ile 
        35                  40                  45              


Gly Lys Ser Val Lys Asp Cys Trp Ala Gly Ala Ala Ala Pro Ser Asp 
    50                  55                  60                  


<210>  3446
<211>  72
<212>  PRT
<213>  Homo Sapiens

<400>  3446

Met Asp Phe Pro Cys Leu Trp Leu Gly Leu Leu Leu Pro Leu Val Ala 
1               5                   10                  15      


Ala Leu Asp Phe Asn Tyr His Arg Gln Glu Gly Met Glu Ala Phe Leu 
            20                  25                  30          


Lys Thr Val Ala Gln Asn Tyr Ser Ser Val Thr His Leu His Ser Ile 
        35                  40                  45              


Gly Lys Ser Val Lys Glu Thr Cys Gly Phe Leu Leu Trp Gly Gly Phe 
    50                  55                  60                  


Gln Arg Asn Thr Glu Leu Gly Phe 
65                  70          


<210>  3447
<211>  136
<212>  PRT
<213>  Homo Sapiens

<400>  3447

Met Asp Phe Pro Cys Leu Trp Leu Gly Leu Leu Leu Pro Leu Val Ala 
1               5                   10                  15      


Ala Leu Asp Phe Asn Tyr His Arg Gln Glu Gly Met Glu Ala Phe Leu 
            20                  25                  30          


Lys Thr Val Ala Gln Asn Tyr Ser Ser Val Thr His Leu His Ser Ile 
        35                  40                  45              


Gly Lys Ser Val Lys Gly Arg Asn Leu Trp Val Leu Val Val Gly Arg 
    50                  55                  60                  


Phe Pro Lys Glu His Arg Ile Gly Ile Pro Glu Phe Lys Tyr Val Ala 
65                  70                  75                  80  


Asn Met His Gly Asp Glu Thr Val Gly Arg Glu Leu Leu Leu His Leu 
                85                  90                  95      


Ile Asp Tyr Leu Val Thr Ser Asp Gly Lys Asp Pro Glu Ile Thr Asn 
            100                 105                 110         


Leu Ile Asn Ser Thr Arg Ile His Ile Met Pro Ser Met Asn Pro Asp 
        115                 120                 125             


Gly Phe Glu Ala Val Lys Lys Pro 
    130                 135     


<210>  3448
<211>  249
<212>  PRT
<213>  Homo Sapiens

<400>  3448

Met Asp Phe Pro Cys Leu Trp Leu Gly Leu Leu Leu Pro Leu Val Ala 
1               5                   10                  15      


Ala Leu Asp Phe Asn Tyr His Arg Gln Glu Gly Met Glu Ala Phe Leu 
            20                  25                  30          


Lys Thr Val Ala Gln Asn Tyr Ser Ser Val Thr His Leu His Ser Ile 
        35                  40                  45              


Gly Lys Ser Val Lys Gly Arg Asn Leu Trp Val Leu Val Val Gly Arg 
    50                  55                  60                  


Phe Pro Lys Glu His Arg Ile Gly Ile Pro Glu Phe Lys Tyr Val Ala 
65                  70                  75                  80  


Asn Met His Gly Asp Glu Thr Val Gly Arg Glu Leu Leu Leu His Leu 
                85                  90                  95      


Ile Asp Tyr Leu Val Thr Ser Asp Gly Lys Asp Pro Glu Ile Thr Asn 
            100                 105                 110         


Leu Ile Asn Ser Thr Arg Ile His Ile Met Pro Ser Met Asn Pro Asp 
        115                 120                 125             


Gly Phe Glu Ala Val Lys Lys Pro Asp Cys Tyr Tyr Ser Ile Gly Arg 
    130                 135                 140                 


Glu Asn Tyr Asn Gln Tyr Asp Leu Asn Arg Asn Phe Pro Asp Ala Phe 
145                 150                 155                 160 


Glu Tyr Asn Asn Val Ser Arg Gln Pro Glu Thr Val Ala Val Met Lys 
                165                 170                 175     


Trp Leu Lys Thr Glu Thr Phe Val Leu Ser Ala Asn Leu His Gly Gly 
            180                 185                 190         


Ala Leu Val Ala Ser Tyr Pro Phe Asp Asn Gly Val Gln Ala Thr Gly 
        195                 200                 205             


Ala Leu Tyr Ser Arg Ser Leu Thr Pro Asp Asp Asp Val Phe Gln Tyr 
    210                 215                 220                 


Leu Ala His Thr Tyr Ala Ser Arg Asn Pro Asn Met Lys Lys Gly Asp 
225                 230                 235                 240 


Glu Cys Lys Asn Lys Met Asn Phe Pro 
                245                 


<210>  3449
<211>  443
<212>  PRT
<213>  Homo Sapiens

<400>  3449

Met Asp Phe Pro Cys Leu Trp Leu Gly Leu Leu Leu Pro Leu Val Ala 
1               5                   10                  15      


Ala Leu Asp Phe Asn Tyr His Arg Gln Glu Gly Met Glu Ala Phe Leu 
            20                  25                  30          


Lys Thr Val Ala Gln Asn Tyr Ser Ser Val Thr His Leu His Ser Ile 
        35                  40                  45              


Gly Lys Ser Val Lys Gly Arg Asn Leu Trp Val Leu Val Val Gly Arg 
    50                  55                  60                  


Phe Pro Lys Glu His Arg Ile Gly Ile Pro Glu Phe Lys Tyr Val Ala 
65                  70                  75                  80  


Asn Met His Gly Asp Glu Thr Val Gly Arg Glu Leu Leu Leu His Leu 
                85                  90                  95      


Ile Asp Tyr Leu Val Thr Ser Asp Gly Lys Asp Pro Glu Ile Thr Asn 
            100                 105                 110         


Leu Ile Asn Ser Thr Arg Ile His Ile Met Pro Ser Met Asn Pro Asp 
        115                 120                 125             


Gly Phe Glu Ala Val Lys Lys Pro Asp Cys Tyr Tyr Ser Ile Gly Arg 
    130                 135                 140                 


Glu Asn Tyr Asn Gln Tyr Asp Leu Asn Arg Asn Phe Pro Asp Ala Phe 
145                 150                 155                 160 


Glu Tyr Asn Asn Val Ser Arg Gln Pro Glu Thr Val Ala Val Met Lys 
                165                 170                 175     


Trp Leu Lys Thr Glu Thr Phe Val Leu Ser Ala Asn Leu His Gly Gly 
            180                 185                 190         


Ala Leu Val Ala Ser Tyr Pro Phe Asp Asn Gly Val Gln Ala Thr Gly 
        195                 200                 205             


Ala Leu Tyr Ser Arg Ser Leu Thr Pro Asp Asp Asp Val Phe Gln Tyr 
    210                 215                 220                 


Leu Ala His Thr Tyr Ala Ser Arg Asn Pro Asn Met Lys Lys Gly Asp 
225                 230                 235                 240 


Glu Cys Lys Asn Lys Met Asn Phe Pro Asn Gly Val Thr Asn Gly Tyr 
                245                 250                 255     


Ser Trp Tyr Pro Leu Gln Gly Gly Met Gln Asp Tyr Asn Tyr Ile Trp 
            260                 265                 270         


Ala Gln Cys Phe Glu Ile Thr Leu Glu Leu Ser Cys Cys Lys Tyr Pro 
        275                 280                 285             


Arg Glu Glu Lys Leu Pro Ser Phe Trp Asn Asn Asn Lys Ala Ser Leu 
    290                 295                 300                 


Ile Glu Tyr Ile Lys Gln Val His Leu Gly Val Lys Gly Gln Val Phe 
305                 310                 315                 320 


Asp Gln Asn Gly Asn Pro Leu Pro Asn Val Ile Val Glu Val Gln Asp 
                325                 330                 335     


Arg Lys His Ile Cys Pro Tyr Arg Thr Asn Lys Tyr Gly Glu Tyr Tyr 
            340                 345                 350         


Leu Leu Leu Leu Pro Gly Ser Tyr Ile Ile Asn Val Thr Val Pro Gly 
        355                 360                 365             


His Asp Pro His Ile Thr Lys Val Ile Ile Pro Glu Lys Ser Gln Asn 
    370                 375                 380                 


Phe Ser Ala Leu Lys Lys Asp Ile Leu Leu Pro Phe Gln Gly Gln Leu 
385                 390                 395                 400 


Asp Ser Ile Pro Val Ser Asn Pro Ser Cys Pro Met Ile Pro Leu Tyr 
                405                 410                 415     


Arg Asn Leu Pro Asp His Ser Ala Ala Thr Lys Pro Ser Leu Phe Leu 
            420                 425                 430         


Phe Leu Val Ser Leu Leu His Ile Phe Phe Lys 
        435                 440             


<210>  3450
<211>  443
<212>  PRT
<213>  Homo Sapiens

<400>  3450

Met Asp Phe Pro Cys Leu Trp Leu Gly Leu Leu Leu Pro Leu Val Ala 
1               5                   10                  15      


Ala Leu Asp Phe Asn Tyr His Arg Gln Glu Gly Met Glu Ala Phe Leu 
            20                  25                  30          


Lys Thr Val Ala Gln Asn Tyr Ser Ser Val Thr His Leu His Ser Ile 
        35                  40                  45              


Gly Lys Ser Val Lys Gly Arg Asn Leu Trp Val Leu Val Val Gly Arg 
    50                  55                  60                  


Phe Pro Lys Glu His Arg Ile Gly Ile Pro Glu Phe Lys Tyr Val Ala 
65                  70                  75                  80  


Asn Met His Gly Asp Glu Thr Val Gly Arg Glu Leu Leu Leu His Leu 
                85                  90                  95      


Ile Asp Tyr Leu Val Thr Ser Asp Gly Lys Asp Pro Glu Ile Thr Asn 
            100                 105                 110         


Leu Ile Asn Ser Thr Arg Ile His Ile Met Pro Ser Met Asn Pro Asp 
        115                 120                 125             


Gly Phe Glu Ala Val Lys Lys Pro Asp Cys Tyr Tyr Ser Ile Gly Arg 
    130                 135                 140                 


Glu Asn Tyr Asn Gln Tyr Asp Leu Asn Arg Asn Phe Pro Asp Ala Phe 
145                 150                 155                 160 


Glu Tyr Asn Asn Val Ser Arg Gln Pro Glu Thr Val Ala Val Met Lys 
                165                 170                 175     


Trp Leu Lys Thr Glu Thr Phe Val Leu Ser Ala Asn Leu His Gly Gly 
            180                 185                 190         


Ala Leu Val Ala Ser Tyr Pro Phe Asp Asn Gly Val Gln Ala Thr Gly 
        195                 200                 205             


Ala Leu Tyr Ser Arg Ser Leu Thr Pro Asp Asp Asp Val Phe Gln Tyr 
    210                 215                 220                 


Leu Ala His Thr Tyr Ala Ser Arg Asn Pro Asn Met Lys Lys Gly Asp 
225                 230                 235                 240 


Glu Cys Lys Asn Lys Met Asn Phe Pro Asn Gly Val Thr Asn Gly Tyr 
                245                 250                 255     


Ser Trp Tyr Pro Leu Gln Gly Gly Met Gln Asp Tyr Asn Tyr Ile Trp 
            260                 265                 270         


Ala Gln Cys Phe Glu Ile Thr Leu Glu Leu Ser Cys Cys Lys Tyr Pro 
        275                 280                 285             


Arg Glu Glu Lys Leu Pro Ser Phe Trp Asn Asn Asn Lys Ala Ser Leu 
    290                 295                 300                 


Ile Glu Tyr Ile Lys Gln Val His Leu Gly Val Lys Gly Gln Val Phe 
305                 310                 315                 320 


Asp Gln Asn Gly Asn Pro Leu Pro Asn Val Ile Val Glu Val Gln Asp 
                325                 330                 335     


Arg Lys His Ile Cys Pro Tyr Arg Thr Asn Lys Tyr Gly Glu Tyr Tyr 
            340                 345                 350         


Leu Leu Leu Leu Pro Gly Ser Tyr Ile Ile Asn Val Thr Val Pro Gly 
        355                 360                 365             


His Asp Pro His Ile Thr Lys Val Ile Ile Pro Glu Lys Ser Gln Asn 
    370                 375                 380                 


Phe Ser Ala Leu Lys Lys Asp Ile Leu Leu Pro Phe Gln Gly Gln Leu 
385                 390                 395                 400 


Asp Ser Ile Pro Val Ser Asn Pro Ser Cys Pro Met Ile Pro Leu Tyr 
                405                 410                 415     


Arg Asn Leu Pro Asp His Ser Ala Ala Thr Lys Pro Ser Leu Phe Leu 
            420                 425                 430         


Phe Leu Val Ser Leu Leu His Ile Phe Phe Lys 
        435                 440             


<210>  3451
<211>  443
<212>  PRT
<213>  Homo Sapiens

<400>  3451

Met Asp Phe Pro Cys Leu Trp Leu Gly Leu Leu Leu Pro Leu Val Ala 
1               5                   10                  15      


Ala Leu Asp Phe Asn Tyr His Arg Gln Glu Gly Met Glu Ala Phe Leu 
            20                  25                  30          


Lys Thr Val Ala Gln Asn Tyr Ser Ser Val Thr His Leu His Ser Ile 
        35                  40                  45              


Gly Lys Ser Val Lys Gly Arg Asn Leu Trp Val Leu Val Val Gly Arg 
    50                  55                  60                  


Phe Pro Lys Glu His Arg Ile Gly Ile Pro Glu Phe Lys Tyr Val Ala 
65                  70                  75                  80  


Asn Met His Gly Asp Glu Thr Val Gly Arg Glu Leu Leu Leu His Leu 
                85                  90                  95      


Ile Asp Tyr Leu Val Thr Ser Asp Gly Lys Asp Pro Glu Ile Thr Asn 
            100                 105                 110         


Leu Ile Asn Ser Thr Arg Ile His Ile Met Pro Ser Met Asn Pro Asp 
        115                 120                 125             


Gly Phe Glu Ala Val Lys Lys Pro Asp Cys Tyr Tyr Ser Ile Gly Arg 
    130                 135                 140                 


Glu Asn Tyr Asn Gln Tyr Asp Leu Asn Arg Asn Phe Pro Asp Ala Phe 
145                 150                 155                 160 


Glu Tyr Asn Asn Val Ser Arg Gln Pro Glu Thr Val Ala Val Met Lys 
                165                 170                 175     


Trp Leu Lys Thr Glu Thr Phe Val Leu Ser Ala Asn Leu His Gly Gly 
            180                 185                 190         


Ala Leu Val Ala Ser Tyr Pro Phe Asp Asn Gly Val Gln Ala Thr Gly 
        195                 200                 205             


Ala Leu Tyr Ser Arg Ser Leu Thr Pro Asp Asp Asp Val Phe Gln Tyr 
    210                 215                 220                 


Leu Ala His Thr Tyr Ala Ser Arg Asn Pro Asn Met Lys Lys Gly Asp 
225                 230                 235                 240 


Glu Cys Lys Asn Lys Met Asn Phe Pro Asn Gly Val Thr Asn Gly Tyr 
                245                 250                 255     


Ser Trp Tyr Pro Leu Gln Gly Gly Met Gln Asp Tyr Asn Tyr Ile Trp 
            260                 265                 270         


Ala Gln Cys Phe Glu Ile Thr Leu Glu Leu Ser Cys Cys Lys Tyr Pro 
        275                 280                 285             


Arg Glu Glu Lys Leu Pro Ser Phe Trp Asn Asn Asn Lys Ala Ser Leu 
    290                 295                 300                 


Ile Glu Tyr Ile Lys Gln Val His Leu Gly Val Lys Gly Gln Val Phe 
305                 310                 315                 320 


Asp Gln Asn Gly Asn Pro Leu Pro Asn Val Ile Val Glu Val Gln Asp 
                325                 330                 335     


Arg Lys His Ile Cys Pro Tyr Arg Thr Asn Lys Tyr Gly Glu Tyr Tyr 
            340                 345                 350         


Leu Leu Leu Leu Pro Gly Ser Tyr Ile Ile Asn Val Thr Val Pro Gly 
        355                 360                 365             


His Asp Pro His Ile Thr Lys Val Ile Ile Pro Glu Lys Ser Gln Asn 
    370                 375                 380                 


Phe Ser Ala Leu Lys Lys Asp Ile Leu Leu Pro Phe Gln Gly Gln Leu 
385                 390                 395                 400 


Asp Ser Ile Pro Val Ser Asn Pro Ser Cys Pro Met Ile Pro Leu Tyr 
                405                 410                 415     


Arg Asn Leu Pro Asp His Ser Ala Ala Thr Lys Pro Ser Leu Phe Leu 
            420                 425                 430         


Phe Leu Val Ser Leu Leu His Ile Phe Phe Lys 
        435                 440             


<210>  3452
<211>  35
<212>  PRT
<213>  Homo Sapiens

<400>  3452

Ser Cys Pro Met Ile Pro Leu Tyr Arg Asn Leu Pro Asp His Ser Ala 
1               5                   10                  15      


Ala Thr Lys Pro Ser Leu Phe Leu Phe Leu Val Ser Leu Leu His Ile 
            20                  25                  30          


Phe Phe Lys 
        35  


<210>  3453
<211>  198
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3453

Xaa Pro Phe Asp Asn Gly Val Gln Ala Thr Gly Ala Leu Tyr Ser Arg 
1               5                   10                  15      


Ser Leu Thr Pro Asp Asp Asp Val Phe Gln Tyr Leu Ala His Thr Tyr 
            20                  25                  30          


Ala Ser Arg Asn Pro Asn Met Lys Lys Gly Asp Glu Cys Lys Asn Lys 
        35                  40                  45              


Met Asn Phe Pro Asn Gly Val Thr Asn Gly Tyr Ser Trp Tyr Pro Leu 
    50                  55                  60                  


Gln Gly Gly Met Gln Asp Tyr Asn Tyr Ile Trp Ala Gln Cys Phe Glu 
65                  70                  75                  80  


Ile Thr Leu Glu Leu Ser Cys Cys Lys Tyr Pro Arg Glu Glu Lys Leu 
                85                  90                  95      


Pro Ser Phe Trp Asn Asn Asn Lys Ala Ser Leu Ile Glu Tyr Ile Lys 
            100                 105                 110         


Gln Val His Leu Gly Val Lys Gly Gln Val Phe Asp Gln Asn Gly Asn 
        115                 120                 125             


Pro Leu Pro Asn Val Ile Val Glu Val Gln Asp Arg Lys His Ile Cys 
    130                 135                 140                 


Pro Tyr Arg Thr Asn Lys Tyr Gly Glu Tyr Tyr Leu Leu Leu Leu Pro 
145                 150                 155                 160 


Gly Ser Tyr Ile Ile Asn Val Thr Val Pro Gly His Asp Pro His Ile 
                165                 170                 175     


Thr Lys Leu Arg Ser Phe Ala Cys Asn Arg Gly Gln Asp Glu Phe Cys 
            180                 185                 190         


Leu Thr Ser Leu Met Ser 
        195             


<210>  3454
<211>  204
<212>  PRT
<213>  Homo Sapiens

<400>  3454

Met His Ser Phe Asn Phe Val Leu Ser Ala Asn Leu His Gly Gly Ala 
1               5                   10                  15      


Val Val Ala Asn Tyr Pro Tyr Asp Lys Ser Phe Glu His Arg Val Arg 
            20                  25                  30          


Gly Val Arg Arg Thr Ala Ser Thr Pro Thr Pro Asp Asp Lys Leu Phe 
        35                  40                  45              


Gln Lys Leu Ala Lys Val Tyr Ser Tyr Ala His Gly Trp Met Phe Gln 
    50                  55                  60                  


Gly Trp Asn Cys Gly Asp Tyr Phe Pro Asp Gly Ile Thr Asn Gly Ala 
65                  70                  75                  80  


Ser Trp Tyr Ser Leu Ser Lys Gly Met Gln Asp Phe Asn Tyr Leu His 
                85                  90                  95      


Thr Asn Cys Phe Glu Ile Thr Leu Glu Leu Ser Cys Asp Lys Phe Pro 
            100                 105                 110         


Pro Glu Glu Glu Leu Gln Arg Glu Trp Leu Gly Asn Arg Glu Ala Leu 
        115                 120                 125             


Ile Gln Phe Leu Glu Gln Val His Gln Gly Ile Lys Gly Met Val Leu 
    130                 135                 140                 


Asp Glu Asn Tyr Asn Asn Leu Ala Asn Ala Val Ile Ser Val Ser Gly 
145                 150                 155                 160 


Ile Asn His Asp Val Thr Ser Gly Asp His Gly Asp Tyr Phe Arg Leu 
                165                 170                 175     


Leu Leu Pro Gly Ile Tyr Thr Val Ser Ala Thr Ala Pro Gly Tyr Asp 
            180                 185                 190         


Pro Glu Thr Val Thr Val Thr Val Gly Pro Ala Glu 
        195                 200                 


<210>  3455
<211>  458
<212>  PRT
<213>  Homo Sapiens

<400>  3455

Met Ser Asp Leu Leu Ser Val Phe Leu His Leu Leu Leu Leu Phe Lys 
1               5                   10                  15      


Leu Val Ala Pro Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val 
            20                  25                  30          


Arg Thr Leu Tyr Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val 
        35                  40                  45              


Tyr Ser Ile Gly Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu 
    50                  55                  60                  


Phe Ser Asp His Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys 
65                  70                  75                  80  


Tyr Val Gly Asn Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met 
                85                  90                  95      


Leu Gln Leu Ser Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln 
            100                 105                 110         


Arg Ile Val Gln Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser 
        115                 120                 125             


Met Asn Pro Asp Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys 
    130                 135                 140                 


Pro Gly Tyr Leu Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn 
145                 150                 155                 160 


Arg Asn Phe Pro Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr 
                165                 170                 175     


Gly Gly Pro Asn His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln 
            180                 185                 190         


Val Glu Pro Glu Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn 
        195                 200                 205             


Phe Val Leu Ser Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr 
    210                 215                 220                 


Pro Tyr Asp Lys Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr 
225                 230                 235                 240 


Ala Ser Thr Pro Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys 
                245                 250                 255     


Val Tyr Ser Tyr Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly 
            260                 265                 270         


Asp Tyr Phe Pro Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu 
        275                 280                 285             


Ser Lys Gly Met Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu 
    290                 295                 300                 


Ile Thr Leu Glu Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu 
305                 310                 315                 320 


Gln Arg Glu Trp Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu 
                325                 330                 335     


Gln Val His Gln Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn 
            340                 345                 350         


Asn Leu Ala Asn Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val 
        355                 360                 365             


Thr Ser Gly Asp His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile 
    370                 375                 380                 


Tyr Thr Val Ser Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr 
385                 390                 395                 400 


Val Thr Val Gly Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys 
                405                 410                 415     


Arg Ser Ile Pro Gln Val Ser Pro Val Arg Arg Ala Pro Ser Arg Arg 
            420                 425                 430         


His Gly Val Arg Ala Lys Val Gln Pro Gln Ala Arg Lys Lys Glu Met 
        435                 440                 445             


Glu Met Arg Gln Leu Gln Arg Gly Pro Ala 
    450                 455             


<210>  3456
<211>  545
<212>  PRT
<213>  Homo Sapiens

<400>  3456

Met Leu Pro Gly Ala Trp Leu Leu Trp Thr Ser Leu Leu Leu Leu Ala 
1               5                   10                  15      


Arg Pro Ala Gln Pro Cys Pro Met Gly Cys Asp Cys Phe Val Gln Glu 
            20                  25                  30          


Val Phe Cys Ser Asp Glu Glu Leu Ala Thr Val Pro Leu Asp Ile Pro 
        35                  40                  45              


Pro Tyr Thr Lys Asn Ile Ile Phe Val Glu Thr Ser Phe Thr Thr Leu 
    50                  55                  60                  


Glu Thr Arg Ala Phe Gly Ser Asn Pro Asn Leu Thr Lys Val Val Phe 
65                  70                  75                  80  


Leu Asn Thr Gln Leu Cys Gln Phe Arg Pro Asp Ala Phe Gly Gly Leu 
                85                  90                  95      


Pro Arg Leu Glu Asp Leu Glu Val Thr Gly Ser Ser Phe Leu Asn Leu 
            100                 105                 110         


Ser Thr Asn Ile Phe Ser Asn Leu Thr Ser Leu Gly Lys Leu Thr Leu 
        115                 120                 125             


Asn Phe Asn Met Leu Glu Ala Leu Pro Glu Gly Leu Phe Gln His Leu 
    130                 135                 140                 


Ala Ala Leu Glu Ser Leu His Leu Gln Gly Asn Gln Leu Gln Ala Leu 
145                 150                 155                 160 


Pro Arg Arg Leu Phe Gln Pro Leu Thr His Leu Lys Thr Leu Asn Leu 
                165                 170                 175     


Ala Gln Asn Leu Leu Ala Gln Leu Pro Glu Glu Leu Phe His Pro Leu 
            180                 185                 190         


Thr Ser Leu Gln Thr Leu Lys Leu Ser Asn Asn Ala Leu Ser Gly Leu 
        195                 200                 205             


Pro Gln Gly Val Phe Gly Lys Leu Gly Ser Leu Gln Glu Leu Phe Leu 
    210                 215                 220                 


Asp Ser Asn Asn Ile Ser Glu Leu Pro Pro Gln Val Phe Ser Gln Leu 
225                 230                 235                 240 


Phe Cys Leu Glu Arg Leu Trp Leu Gln Arg Asn Ala Ile Thr His Leu 
                245                 250                 255     


Pro Leu Ser Ile Phe Ala Ser Leu Gly Asn Leu Thr Phe Leu Ser Leu 
            260                 265                 270         


Gln Trp Asn Met Leu Arg Val Leu Pro Ala Gly Leu Phe Ala His Thr 
        275                 280                 285             


Pro Cys Leu Val Gly Leu Ser Leu Thr His Asn Gln Leu Glu Thr Val 
    290                 295                 300                 


Ala Glu Gly Thr Phe Ala His Leu Ser Asn Leu Arg Ser Leu Met Leu 
305                 310                 315                 320 


Ser Tyr Asn Ala Ile Thr His Leu Pro Ala Gly Ile Phe Arg Asp Leu 
                325                 330                 335     


Glu Glu Leu Val Lys Leu Tyr Leu Gly Ser Asn Asn Leu Thr Ala Leu 
            340                 345                 350         


His Pro Ala Leu Phe Gln Asn Leu Ser Lys Leu Glu Leu Leu Ser Leu 
        355                 360                 365             


Ser Lys Asn Gln Leu Thr Thr Leu Pro Glu Gly Ile Phe Asp Thr Asn 
    370                 375                 380                 


Tyr Asn Leu Phe Asn Leu Ala Leu His Gly Asn Pro Trp Gln Cys Asp 
385                 390                 395                 400 


Cys His Leu Ala Tyr Leu Phe Asn Trp Leu Gln Gln Tyr Thr Asp Arg 
                405                 410                 415     


Leu Leu Asn Ile Gln Thr Tyr Cys Ala Gly Pro Ala Tyr Leu Lys Gly 
            420                 425                 430         


Gln Val Val Pro Ala Leu Asn Glu Lys Gln Leu Val Cys Pro Val Thr 
        435                 440                 445             


Arg Asp His Leu Gly Phe Gln Val Thr Trp Pro Asp Glu Ser Lys Ala 
    450                 455                 460                 


Gly Gly Ser Trp Asp Leu Ala Val Gln Glu Arg Ala Ala Arg Ser Gln 
465                 470                 475                 480 


Cys Thr Tyr Ser Asn Pro Glu Gly Thr Val Val Leu Ala Cys Asp Gln 
                485                 490                 495     


Ala Gln Cys Arg Trp Leu Asn Val Gln Leu Ser Pro Gln Gln Gly Ser 
            500                 505                 510         


Leu Gly Leu Gln Tyr Asn Ala Ser Gln Glu Trp Asp Leu Arg Ser Ser 
        515                 520                 525             


Cys Gly Ser Leu Arg Leu Thr Val Ser Ile Glu Ala Arg Ala Ala Gly 
    530                 535                 540                 


Pro 
545 


<210>  3457
<211>  545
<212>  PRT
<213>  Homo Sapiens

<400>  3457

Met Leu Pro Gly Ala Trp Leu Leu Trp Thr Ser Leu Leu Leu Leu Ala 
1               5                   10                  15      


Arg Pro Ala Gln Pro Cys Pro Met Gly Cys Asp Cys Phe Val Gln Glu 
            20                  25                  30          


Val Phe Cys Ser Asp Glu Glu Leu Ala Thr Val Pro Leu Asp Ile Pro 
        35                  40                  45              


Pro Tyr Thr Lys Asn Ile Ile Phe Val Glu Thr Ser Phe Thr Thr Leu 
    50                  55                  60                  


Glu Thr Arg Ala Phe Gly Ser Asn Pro Asn Leu Thr Lys Val Val Phe 
65                  70                  75                  80  


Leu Asn Thr Gln Leu Cys Gln Phe Arg Pro Asp Ala Phe Gly Gly Leu 
                85                  90                  95      


Pro Arg Leu Glu Asp Leu Glu Val Thr Gly Ser Ser Phe Leu Asn Leu 
            100                 105                 110         


Ser Thr Asn Ile Phe Ser Asn Leu Thr Ser Leu Gly Lys Leu Thr Leu 
        115                 120                 125             


Asn Phe Asn Met Leu Glu Ala Leu Pro Glu Gly Leu Phe Gln His Leu 
    130                 135                 140                 


Ala Ala Leu Glu Ser Leu His Leu Gln Gly Asn Gln Leu Gln Ala Leu 
145                 150                 155                 160 


Pro Arg Arg Leu Phe Gln Pro Leu Thr His Leu Lys Thr Leu Asn Leu 
                165                 170                 175     


Ala Gln Asn Leu Leu Ala Gln Leu Pro Glu Glu Leu Phe His Pro Leu 
            180                 185                 190         


Thr Ser Leu Gln Thr Leu Lys Leu Ser Asn Asn Ala Leu Ser Gly Leu 
        195                 200                 205             


Pro Gln Gly Val Phe Gly Lys Leu Gly Ser Leu Gln Glu Leu Phe Leu 
    210                 215                 220                 


Asp Ser Asn Asn Ile Ser Glu Leu Pro Pro Gln Val Phe Ser Gln Leu 
225                 230                 235                 240 


Phe Cys Leu Glu Arg Leu Trp Leu Gln Arg Asn Ala Ile Thr His Leu 
                245                 250                 255     


Pro Leu Ser Ile Phe Ala Ser Leu Gly Asn Leu Thr Phe Leu Ser Leu 
            260                 265                 270         


Gln Trp Asn Met Leu Arg Val Leu Pro Ala Gly Leu Phe Ala His Thr 
        275                 280                 285             


Pro Cys Leu Val Gly Leu Ser Leu Thr His Asn Gln Leu Glu Thr Val 
    290                 295                 300                 


Ala Glu Gly Thr Phe Ala His Leu Ser Asn Leu Arg Ser Leu Met Leu 
305                 310                 315                 320 


Ser Tyr Asn Ala Ile Thr His Leu Pro Ala Gly Ile Phe Arg Asp Leu 
                325                 330                 335     


Glu Glu Leu Val Lys Leu Tyr Leu Gly Ser Asn Asn Leu Thr Ala Leu 
            340                 345                 350         


His Pro Ala Leu Phe Gln Asn Leu Ser Lys Leu Glu Leu Leu Ser Leu 
        355                 360                 365             


Ser Lys Asn Gln Leu Thr Thr Leu Pro Glu Gly Ile Phe Asp Thr Asn 
    370                 375                 380                 


Tyr Asn Leu Phe Asn Leu Ala Leu His Gly Asn Pro Trp Gln Cys Asp 
385                 390                 395                 400 


Cys His Leu Ala Tyr Leu Phe Asn Trp Leu Gln Gln Tyr Thr Asp Arg 
                405                 410                 415     


Leu Leu Asn Ile Gln Thr Tyr Cys Ala Gly Pro Ala Tyr Leu Lys Gly 
            420                 425                 430         


Gln Val Val Pro Ala Leu Asn Glu Lys Gln Leu Val Cys Pro Val Thr 
        435                 440                 445             


Arg Asp His Leu Gly Phe Gln Val Thr Trp Pro Asp Glu Ser Lys Ala 
    450                 455                 460                 


Gly Gly Ser Trp Asp Leu Ala Val Gln Glu Arg Ala Ala Arg Ser Gln 
465                 470                 475                 480 


Cys Thr Tyr Ser Asn Pro Glu Gly Thr Val Val Leu Ala Cys Asp Gln 
                485                 490                 495     


Ala Gln Cys Arg Trp Leu Asn Val Gln Leu Ser Pro Gln Gln Gly Ser 
            500                 505                 510         


Leu Gly Leu Gln Tyr Asn Ala Ser Gln Glu Trp Asp Leu Arg Ser Ser 
        515                 520                 525             


Cys Gly Ser Leu Arg Leu Thr Val Ser Ile Glu Ala Arg Ala Ala Gly 
    530                 535                 540                 


Pro 
545 


<210>  3458
<211>  374
<212>  PRT
<213>  Homo Sapiens

<400>  3458

Met Lys Pro Leu Leu Glu Thr Leu Tyr Leu Leu Gly Met Leu Val Pro 
1               5                   10                  15      


Gly Gly Leu Gly Tyr Asp Arg Ser Leu Ala Gln His Arg Gln Glu Ile 
            20                  25                  30          


Val Asp Lys Ser Val Ser Pro Trp Ser Leu Glu Thr Tyr Ser Tyr Asn 
        35                  40                  45              


Ile Tyr His Pro Met Gly Glu Ile Tyr Glu Trp Met Arg Glu Ile Ser 
    50                  55                  60                  


Glu Lys Tyr Lys Glu Val Val Thr Gln His Phe Leu Gly Val Thr Tyr 
65                  70                  75                  80  


Glu Thr His Pro Met Tyr Tyr Leu Lys Ile Ser Gln Pro Ser Gly Asn 
                85                  90                  95      


Pro Lys Lys Ile Ile Trp Met Asp Cys Gly Ile His Ala Arg Glu Trp 
            100                 105                 110         


Ile Ala Pro Ala Phe Cys Gln Trp Phe Val Lys Glu Ile Leu Gln Asn 
        115                 120                 125             


His Lys Asp Asn Ser Ser Ile Arg Lys Leu Leu Arg Asn Leu Asp Phe 
    130                 135                 140                 


Tyr Val Leu Pro Val Leu Asn Ile Asp Gly Tyr Ile Tyr Thr Trp Thr 
145                 150                 155                 160 


Thr Asp Arg Leu Trp Arg Lys Ser Arg Ser Pro His Asn Asn Gly Thr 
                165                 170                 175     


Cys Phe Gly Thr Asp Leu Asn Arg Asn Phe Asn Ala Ser Trp Cys Ser 
            180                 185                 190         


Ile Gly Ala Ser Arg Asn Cys Gln Asp Gln Thr Phe Cys Gly Thr Gly 
        195                 200                 205             


Pro Val Ser Glu Pro Glu Thr Lys Ala Val Ala Ser Phe Ile Glu Ser 
    210                 215                 220                 


Lys Lys Asp Asp Ile Leu Cys Phe Leu Thr Met His Ser Tyr Gly Gln 
225                 230                 235                 240 


Leu Ile Leu Thr Pro Tyr Gly Tyr Thr Lys Asn Lys Ser Ser Asn His 
                245                 250                 255     


Pro Glu Met Ile Gln Val Gly Gln Lys Ala Ala Asn Ala Leu Lys Ala 
            260                 265                 270         


Lys Tyr Gly Thr Asn Tyr Arg Val Gly Ser Ser Ala Asp Ile Leu Tyr 
        275                 280                 285             


Ala Ser Ser Gly Ser Ser Arg Asp Trp Ala Arg Asp Ile Gly Ile Pro 
    290                 295                 300                 


Phe Ser Tyr Thr Phe Glu Leu Arg Asp Ser Gly Thr Tyr Gly Phe Val 
305                 310                 315                 320 


Leu Pro Glu Ala Gln Ile Gln Pro Thr Cys Glu Glu Thr Met Glu Ala 
                325                 330                 335     


Val Leu Ser Val Leu Asp Asp Val Tyr Ala Lys His Trp His Ser Asp 
            340                 345                 350         


Ser Ala Gly Arg Val Thr Ser Ala Thr Met Leu Leu Gly Leu Leu Val 
        355                 360                 365             


Ser Cys Met Ser Leu Leu 
    370                 


<210>  3459
<211>  130
<212>  PRT
<213>  Homo Sapiens

<400>  3459

Met Lys Phe Leu Ile Phe Ala Phe Phe Gly Gly Val His Leu Leu Ser 
1               5                   10                  15      


Leu Cys Ser Gly Lys Ala Ile Cys Lys Asn Gly Ile Ser Lys Arg Thr 
            20                  25                  30          


Phe Glu Glu Ile Lys Glu Glu Ile Ala Ser Cys Gly Asp Val Ala Lys 
        35                  40                  45              


Ala Ile Ile Asn Leu Ala Val Tyr Gly Lys Ala Gln Asn Arg Ser Tyr 
    50                  55                  60                  


Glu Arg Leu Ala Leu Leu Val Asp Thr Val Gly Pro Arg Leu Ser Gly 
65                  70                  75                  80  


Ser Lys Asn Leu Glu Lys Ala Ile Gln Ile Met Tyr Gln Asn Leu Gln 
                85                  90                  95      


Gln Asp Gly Leu Glu Lys Val His Leu Glu Pro Val Arg Ile Pro His 
            100                 105                 110         


Trp Glu Arg Gly Glu Glu Ser Ala Val Met Leu Glu Pro Arg Ile His 
        115                 120                 125             


Lys Ile 
    130 


<210>  3460
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  3460

Met Lys Phe Leu Ile Phe Ala Phe Phe Gly Gly Val His Leu Leu Ser 
1               5                   10                  15      


Leu Cys Ser Gly Lys Ala Ile Cys Lys Asn Gly Ile Ser Lys Arg Thr 
            20                  25                  30          


Phe Glu Glu Ile Lys Glu Glu Ile Ala Ser Cys Gly Asp Val Ala Lys 
        35                  40                  45              


Ala Ile Ile Asn Leu Ala Val Tyr Gly Lys Ala Gln Asn Arg Ser Tyr 
    50                  55                  60                  


Glu Arg Leu Ala Leu Leu Val Asp Thr Val Gly Pro Arg Leu Ser Gly 
65                  70                  75                  80  


Ser Lys Asn Leu Glu Lys Ala Ile Gln Ile Met Tyr Gln Asn Leu Gln 
                85                  90                  95      


Gln Asp Gly Leu Glu Lys Val His Leu Glu Pro Val Arg Ile Pro His 
            100                 105                 110         


Trp Glu Arg Gly Glu Glu Ser Ala Val Met Leu Glu Pro Arg Ile His 
        115                 120                 125             


Lys Ile Ala 
    130     


<210>  3461
<211>  137
<212>  PRT
<213>  Homo Sapiens

<400>  3461

Met Lys Phe Leu Ile Phe Ala Phe Phe Gly Gly Val His Leu Leu Ser 
1               5                   10                  15      


Leu Cys Ser Gly Lys Ala Ile Cys Lys Asn Gly Ile Ser Lys Arg Thr 
            20                  25                  30          


Phe Glu Glu Ile Lys Glu Glu Ile Ala Ser Cys Gly Asp Val Ala Lys 
        35                  40                  45              


Ala Ile Ile Asn Leu Ala Val Tyr Gly Lys Ala Gln Asn Arg Ser Tyr 
    50                  55                  60                  


Glu Arg Leu Ala Leu Leu Val Asp Thr Val Gly Pro Arg Leu Ser Gly 
65                  70                  75                  80  


Ser Lys Asn Leu Glu Lys Ala Ile Gln Ile Met Tyr Gln Asn Leu Gln 
                85                  90                  95      


Gln Asp Gly Leu Glu Lys Val His Leu Glu Pro Val Arg Ile Pro His 
            100                 105                 110         


Trp Glu Arg Gly Glu Glu Ser Ala Val Met Leu Glu Pro Arg Ile His 
        115                 120                 125             


Lys Ile Ala Ile Leu Gly Leu Gly Ser 
    130                 135         


<210>  3462
<211>  186
<212>  PRT
<213>  Homo Sapiens

<400>  3462

Met Lys Phe Leu Ile Phe Ala Phe Phe Gly Gly Val His Leu Leu Ser 
1               5                   10                  15      


Leu Cys Ser Gly Lys Ala Ile Cys Lys Asn Gly Ile Ser Lys Arg Thr 
            20                  25                  30          


Phe Glu Glu Ile Lys Glu Glu Ile Ala Ser Cys Gly Asp Val Ala Lys 
        35                  40                  45              


Ala Ile Ile Asn Leu Ala Val Tyr Gly Lys Ala Gln Asn Arg Ser Tyr 
    50                  55                  60                  


Glu Arg Leu Ala Leu Leu Val Asp Thr Val Gly Pro Arg Leu Ser Gly 
65                  70                  75                  80  


Ser Lys Asn Leu Glu Lys Ala Ile Gln Ile Met Tyr Gln Asn Leu Gln 
                85                  90                  95      


Gln Asp Gly Leu Glu Lys Val His Leu Glu Pro Val Arg Ile Pro His 
            100                 105                 110         


Trp Glu Arg Gly Glu Glu Ser Ala Val Met Leu Glu Pro Arg Ile His 
        115                 120                 125             


Lys Ile Ala Ile Leu Gly Leu Gly Ser Ser Ile Gly Thr Pro Pro Glu 
    130                 135                 140                 


Gly Ile Thr Ala Glu Val Leu Val Val Thr Ser Phe Asp Glu Leu Gln 
145                 150                 155                 160 


Arg Arg Ala Ser Glu Ala Arg Gly Lys Ile Val Val Tyr Asn Gln Pro 
                165                 170                 175     


Tyr Ile Asn Tyr Ser Arg Thr Val Gln Tyr 
            180                 185     


<210>  3463
<211>  472
<212>  PRT
<213>  Homo Sapiens

<400>  3463

Met Lys Phe Leu Ile Phe Ala Phe Phe Gly Gly Val His Leu Leu Ser 
1               5                   10                  15      


Leu Cys Ser Gly Lys Ala Ile Cys Lys Asn Gly Ile Ser Lys Arg Thr 
            20                  25                  30          


Phe Glu Glu Ile Lys Glu Glu Ile Ala Ser Cys Gly Asp Val Ala Lys 
        35                  40                  45              


Ala Ile Ile Asn Leu Ala Val Tyr Gly Lys Ala Gln Asn Arg Ser Tyr 
    50                  55                  60                  


Glu Arg Leu Ala Leu Leu Val Asp Thr Val Gly Pro Arg Leu Ser Gly 
65                  70                  75                  80  


Ser Lys Asn Leu Glu Lys Ala Ile Gln Ile Met Tyr Gln Asn Leu Gln 
                85                  90                  95      


Gln Asp Gly Leu Glu Lys Val His Leu Glu Pro Val Arg Ile Pro His 
            100                 105                 110         


Trp Glu Arg Gly Glu Glu Ser Ala Val Met Leu Glu Pro Arg Ile His 
        115                 120                 125             


Lys Ile Ala Ile Leu Gly Leu Gly Ser Ser Ile Gly Thr Pro Pro Glu 
    130                 135                 140                 


Gly Ile Thr Ala Glu Val Leu Val Val Thr Ser Phe Asp Glu Leu Gln 
145                 150                 155                 160 


Arg Arg Ala Ser Glu Ala Arg Gly Lys Ile Val Val Tyr Asn Gln Pro 
                165                 170                 175     


Tyr Ile Asn Tyr Ser Arg Thr Val Gln Tyr Arg Thr Gln Gly Ala Val 
            180                 185                 190         


Glu Ala Ala Lys Val Gly Ala Leu Ala Ser Leu Ile Arg Ser Val Ala 
        195                 200                 205             


Ser Phe Ser Ile Tyr Ser Pro His Thr Gly Ile Gln Glu Tyr Gln Asp 
    210                 215                 220                 


Gly Val Pro Lys Ile Pro Thr Ala Cys Ile Thr Val Glu Asp Ala Glu 
225                 230                 235                 240 


Met Met Ser Arg Met Ala Ser His Gly Ile Lys Ile Val Ile Gln Leu 
                245                 250                 255     


Lys Met Gly Ala Lys Thr Tyr Pro Asp Thr Asp Ser Phe Asn Thr Val 
            260                 265                 270         


Ala Glu Ile Thr Gly Ser Lys Tyr Pro Glu Gln Val Val Leu Val Ser 
        275                 280                 285             


Gly His Leu Asp Ser Trp Asp Val Gly Gln Gly Ala Met Asp Asp Gly 
    290                 295                 300                 


Gly Gly Ala Phe Ile Ser Trp Glu Ala Leu Ser Leu Ile Lys Asp Leu 
305                 310                 315                 320 


Gly Leu Arg Pro Lys Arg Thr Leu Arg Leu Val Leu Trp Thr Ala Glu 
                325                 330                 335     


Glu Gln Gly Gly Val Gly Ala Phe Gln Tyr Tyr Gln Leu His Lys Val 
            340                 345                 350         


Asn Ile Ser Asn Tyr Ser Leu Val Met Glu Ser Asp Ala Gly Thr Phe 
        355                 360                 365             


Leu Pro Thr Gly Leu Gln Phe Thr Gly Ser Glu Lys Ala Arg Ala Ile 
    370                 375                 380                 


Met Glu Glu Val Met Ser Leu Leu Gln Pro Leu Asn Ile Thr Gln Val 
385                 390                 395                 400 


Leu Ser His Gly Glu Gly Thr Asp Ile Asn Phe Trp Ile Gln Ala Gly 
                405                 410                 415     


Val Pro Gly Ala Ser Leu Leu Asp Asp Leu Tyr Lys Tyr Phe Phe Phe 
            420                 425                 430         


His His Ser His Gly Asp Thr Met Thr Val Met Asp Pro Lys Gln Met 
        435                 440                 445             


Asn Val Ala Ala Ala Val Trp Ala Val Val Ser Tyr Val Val Ala Asp 
    450                 455                 460                 


Met Glu Glu Met Leu Pro Arg Ser 
465                 470         


<210>  3464
<211>  130
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3464

Xaa Phe Gln Tyr Tyr Gln Leu His Lys Val Asn Ile Ser Asn Tyr Ser 
1               5                   10                  15      


Leu Val Met Glu Ser Asp Ala Gly Thr Phe Leu Pro Thr Gly Leu Gln 
            20                  25                  30          


Phe Thr Gly Ser Glu Lys Ala Arg Ala Ile Met Glu Glu Val Met Ser 
        35                  40                  45              


Leu Leu Gln Pro Leu Asn Ile Thr Gln Val Leu Ser His Gly Glu Gly 
    50                  55                  60                  


Thr Asp Ile Asn Phe Trp Ile Gln Ala Gly Val Pro Gly Ala Ser Leu 
65                  70                  75                  80  


Leu Asp Asp Leu Tyr Lys Tyr Phe Phe Phe His His Ser His Gly Asp 
                85                  90                  95      


Thr Met Thr Val Met Asp Pro Lys Gln Met Asn Val Ala Ala Ala Val 
            100                 105                 110         


Trp Ala Val Val Ser Tyr Val Val Ala Asp Met Glu Glu Met Leu Pro 
        115                 120                 125             


Arg Ser 
    130 


<210>  3465
<211>  141
<212>  PRT
<213>  Homo Sapiens

<400>  3465

Ile Ile Gly Gly Tyr Ala Glu Phe Leu Tyr Gln Ile Gly Leu Leu Asp 
1               5                   10                  15      


Glu Lys Gln Lys Lys Tyr Phe Gln Lys Gln Cys His Glu Cys Ile Glu 
            20                  25                  30          


His Ile Arg Lys Gln Asn Trp Phe Glu Ala Phe Glu Val Leu Ile Tyr 
        35                  40                  45              


Asn Gly Gln Leu Asp Ile Ile Val Ala Ala Ala Leu Thr Glu Arg Ser 
    50                  55                  60                  


Leu Met Gly Met Asp Trp Lys Gly Ser Gln Glu Tyr Lys Lys Ala Glu 
65                  70                  75                  80  


Lys Lys Val Trp Lys Ile Phe Lys Ser Asp Ser Glu Val Ala Gly Tyr 
                85                  90                  95      


Ile Arg Gln Ala Gly Asp Phe His Gln Val Ile Ile Arg Gly Gly Gly 
            100                 105                 110         


His Ile Leu Pro Tyr Asp Gln Pro Leu Arg Ala Phe Asp Met Ile Asn 
        115                 120                 125             


Arg Phe Ile Tyr Gly Lys Gly Trp Asp Pro Tyr Val Gly 
    130                 135                 140     


<210>  3466
<211>  100
<212>  PRT
<213>  Homo Sapiens

<400>  3466

Met Phe Gly Leu Phe Val Glu His Gly Pro Tyr Val Val Thr Ser Asn 
1               5                   10                  15      


Met Thr Leu Arg Asp Arg Asp Phe Pro Trp Thr Thr Thr Leu Ser Met 
            20                  25                  30          


Leu Tyr Ile Asp Asn Pro Val Gly Thr Gly Phe Ser Phe Thr Asp Asp 
        35                  40                  45              


Thr His Gly Tyr Ala Val Asn Glu Asp Asp Val Ala Arg Asp Leu Tyr 
    50                  55                  60                  


Ser Ala Leu Ile Gln Phe Phe Gln Ile Phe Pro Glu Tyr Lys Asn Asn 
65                  70                  75                  80  


Asp Phe Tyr Val Thr Gly Glu Ser Tyr Ala Gly Lys Tyr Val Pro Ala 
                85                  90                  95      


Ile Ala His Leu 
            100 


<210>  3467
<211>  142
<212>  PRT
<213>  Homo Sapiens

<400>  3467

Met Lys Ser Tyr Ala Gly Phe Leu Thr Val Asn Lys Thr Tyr Asn Ser 
1               5                   10                  15      


Asn Leu Phe Phe Trp Phe Phe Pro Ala Gln Ile Gln Pro Glu Asp Ala 
            20                  25                  30          


Pro Val Val Leu Trp Leu Gln Gly Gly Pro Gly Gly Ser Ser Met Phe 
        35                  40                  45              


Gly Leu Phe Val Glu His Gly Pro Tyr Val Val Thr Ser Asn Met Thr 
    50                  55                  60                  


Leu Arg Asp Arg Asp Phe Pro Trp Thr Thr Thr Leu Ser Met Leu Tyr 
65                  70                  75                  80  


Ile Asp Asn Pro Val Gly Thr Gly Phe Ser Phe Thr Asp Asp Thr His 
                85                  90                  95      


Gly Tyr Ala Val Asn Glu Asp Asp Val Ala Arg Asp Leu Tyr Ser Ala 
            100                 105                 110         


Leu Ile Gln Phe Phe Gln Ile Phe Pro Glu Tyr Lys Asn Asn Asp Phe 
        115                 120                 125             


Tyr Val Thr Gly Glu Ser Tyr Ala Gly Lys Tyr Val Pro Ala 
    130                 135                 140         


<210>  3468
<211>  244
<212>  PRT
<213>  Homo Sapiens

<400>  3468

Met Lys Ser Tyr Ala Gly Phe Leu Thr Val Asn Lys Thr Tyr Asn Ser 
1               5                   10                  15      


Asn Leu Phe Phe Trp Phe Phe Pro Ala Gln Ile Gln Pro Glu Asp Ala 
            20                  25                  30          


Pro Val Val Leu Trp Leu Gln Gly Gly Pro Gly Gly Ser Ser Met Phe 
        35                  40                  45              


Gly Leu Phe Val Glu His Gly Pro Tyr Val Val Thr Ser Asn Met Thr 
    50                  55                  60                  


Leu Arg Asp Arg Asp Phe Pro Trp Thr Thr Thr Leu Ser Met Leu Tyr 
65                  70                  75                  80  


Ile Asp Asn Pro Val Gly Thr Gly Phe Ser Phe Thr Asp Asp Thr His 
                85                  90                  95      


Gly Tyr Ala Val Asn Glu Asp Asp Val Ala Arg Asp Leu Tyr Ser Ala 
            100                 105                 110         


Leu Ile Gln Phe Phe Gln Ile Phe Pro Glu Tyr Lys Asn Asn Asp Phe 
        115                 120                 125             


Tyr Val Thr Gly Glu Ser Tyr Ala Gly Lys Tyr Val Pro Ala Ile Ala 
    130                 135                 140                 


His Leu Ile His Ser Leu Asn Pro Val Arg Glu Val Lys Ile Asn Leu 
145                 150                 155                 160 


Asn Gly Ile Ala Ile Gly Asp Gly Tyr Ser Asp Pro Glu Ser Ile Ile 
                165                 170                 175     


Gly Gly Tyr Ala Glu Phe Leu Tyr Gln Ile Gly Leu Leu Asp Glu Lys 
            180                 185                 190         


Gln Lys Lys Tyr Phe Gln Lys Gln Cys His Glu Cys Ile Glu His Ile 
        195                 200                 205             


Arg Lys Gln Asn Trp Phe Glu Ala Phe Glu Ile Leu Asp Lys Leu Leu 
    210                 215                 220                 


Asp Gly Asp Leu Thr Ser Asp Pro Ser Tyr Phe Gln Asn Val Thr Gly 
225                 230                 235                 240 


Cys Ser Asn Tyr 
                


<210>  3469
<211>  6
<212>  PRT
<213>  Homo Sapiens

<400>  3469

Met Val Gly Ala Met Trp 
1               5       


<210>  3470
<211>  43
<212>  PRT
<213>  Homo Sapiens

<400>  3470

Met Val Gly Ala Met Trp Lys Val Ile Val Ser Leu Val Leu Leu Met 
1               5                   10                  15      


Pro Gly Pro Cys Asp Gly Leu Phe Arg Ser Leu Tyr Arg Ser Val Ser 
            20                  25                  30          


Met Pro Pro Lys Gly Asp Ser Gly Gln Pro Leu 
        35                  40              


<210>  3471
<211>  52
<212>  PRT
<213>  Homo Sapiens

<400>  3471

Met Val Gly Ala Met Trp Lys Val Ile Val Ser Leu Val Leu Leu Met 
1               5                   10                  15      


Pro Gly Pro Cys Asp Gly Leu Phe Arg Ser Leu Tyr Arg Ser Val Ser 
            20                  25                  30          


Met Pro Pro Lys Gly Asp Ser Gly Gln Pro Leu Phe Leu Thr Pro Tyr 
        35                  40                  45              


Ile Glu Ala Gly 
    50          


<210>  3472
<211>  476
<212>  PRT
<213>  Homo Sapiens

<400>  3472

Met Val Gly Ala Met Trp Lys Val Ile Val Ser Leu Val Leu Leu Met 
1               5                   10                  15      


Pro Gly Pro Cys Asp Gly Leu Phe Arg Ser Leu Tyr Arg Ser Val Ser 
            20                  25                  30          


Met Pro Pro Lys Gly Asp Ser Gly Gln Pro Leu Phe Leu Thr Pro Tyr 
        35                  40                  45              


Ile Glu Ala Gly Lys Ile Gln Lys Gly Arg Glu Leu Ser Leu Val Gly 
    50                  55                  60                  


Pro Phe Pro Gly Leu Asn Met Lys Ser Tyr Ala Gly Phe Leu Thr Val 
65                  70                  75                  80  


Asn Lys Thr Tyr Asn Ser Asn Leu Phe Phe Trp Phe Phe Pro Ala Gln 
                85                  90                  95      


Ile Gln Pro Glu Asp Ala Pro Val Val Leu Trp Leu Gln Gly Gly Pro 
            100                 105                 110         


Gly Gly Ser Ser Met Phe Gly Leu Phe Val Glu His Gly Pro Tyr Val 
        115                 120                 125             


Val Thr Ser Asn Met Thr Leu Arg Asp Arg Asp Phe Pro Trp Thr Thr 
    130                 135                 140                 


Thr Leu Ser Met Leu Tyr Ile Asp Asn Pro Val Gly Thr Gly Phe Ser 
145                 150                 155                 160 


Phe Thr Asp Asp Thr His Gly Tyr Ala Val Asn Glu Asp Asp Val Ala 
                165                 170                 175     


Arg Asp Leu Tyr Ser Ala Leu Ile Gln Phe Phe Gln Ile Phe Pro Glu 
            180                 185                 190         


Tyr Lys Asn Asn Asp Phe Tyr Val Thr Gly Glu Ser Tyr Ala Gly Lys 
        195                 200                 205             


Tyr Val Pro Ala Ile Ala His Leu Ile His Ser Leu Asn Pro Val Arg 
    210                 215                 220                 


Glu Val Lys Ile Asn Leu Asn Gly Ile Ala Ile Gly Asp Gly Tyr Ser 
225                 230                 235                 240 


Asp Pro Glu Ser Ile Ile Gly Gly Tyr Ala Glu Phe Leu Tyr Gln Ile 
                245                 250                 255     


Gly Leu Leu Asp Glu Lys Gln Lys Lys Tyr Phe Gln Lys Gln Cys His 
            260                 265                 270         


Glu Cys Ile Glu His Ile Arg Lys Gln Asn Trp Phe Glu Ala Phe Glu 
        275                 280                 285             


Ile Leu Asp Lys Leu Leu Asp Gly Asp Leu Thr Ser Asp Pro Ser Tyr 
    290                 295                 300                 


Phe Gln Asn Val Thr Gly Cys Ser Asn Tyr Tyr Asn Phe Leu Arg Cys 
305                 310                 315                 320 


Thr Glu Pro Glu Asp Gln Leu Tyr Tyr Val Lys Phe Leu Ser Leu Pro 
                325                 330                 335     


Glu Val Arg Gln Ala Ile His Val Gly Asn Gln Thr Phe Asn Asp Gly 
            340                 345                 350         


Thr Ile Val Glu Lys Tyr Leu Arg Glu Asp Thr Val Gln Ser Val Lys 
        355                 360                 365             


Pro Trp Leu Thr Glu Ile Met Asn Asn Tyr Lys Val Leu Ile Tyr Asn 
    370                 375                 380                 


Gly Gln Leu Asp Ile Ile Val Ala Ala Ala Leu Thr Glu Arg Ser Leu 
385                 390                 395                 400 


Met Gly Met Asp Trp Lys Gly Ser Gln Glu Tyr Lys Lys Ala Glu Lys 
                405                 410                 415     


Lys Val Trp Lys Ile Phe Lys Ser Asp Ser Glu Val Ala Gly Tyr Ile 
            420                 425                 430         


Arg Gln Ala Gly Asp Phe His Gln Val Ile Ile Arg Gly Gly Gly His 
        435                 440                 445             


Ile Leu Pro Tyr Asp Gln Pro Leu Arg Ala Phe Asp Met Ile Asn Arg 
    450                 455                 460                 


Phe Ile Tyr Gly Lys Gly Trp Asp Pro Tyr Val Gly 
465                 470                 475     


<210>  3473
<211>  476
<212>  PRT
<213>  Homo Sapiens

<400>  3473

Met Val Gly Ala Met Trp Lys Val Ile Val Ser Leu Val Leu Leu Met 
1               5                   10                  15      


Pro Gly Pro Cys Asp Gly Leu Phe Arg Ser Leu Tyr Arg Ser Val Ser 
            20                  25                  30          


Met Pro Pro Lys Gly Asp Ser Gly Gln Pro Leu Phe Leu Thr Pro Tyr 
        35                  40                  45              


Ile Glu Ala Gly Lys Ile Gln Lys Gly Arg Glu Leu Ser Leu Val Gly 
    50                  55                  60                  


Pro Phe Pro Gly Leu Asn Met Lys Ser Tyr Ala Gly Phe Leu Thr Val 
65                  70                  75                  80  


Asn Lys Thr Tyr Asn Ser Asn Leu Phe Phe Trp Phe Phe Pro Ala Gln 
                85                  90                  95      


Ile Gln Pro Glu Asp Ala Pro Val Val Leu Trp Leu Gln Gly Gly Pro 
            100                 105                 110         


Gly Gly Ser Ser Met Phe Gly Leu Phe Val Glu His Gly Pro Tyr Val 
        115                 120                 125             


Val Thr Ser Asn Met Thr Leu Arg Asp Arg Asp Phe Pro Trp Thr Thr 
    130                 135                 140                 


Thr Leu Ser Met Leu Tyr Ile Asp Asn Pro Val Gly Thr Gly Phe Ser 
145                 150                 155                 160 


Phe Thr Asp Asp Thr His Gly Tyr Ala Val Asn Glu Asp Asp Val Ala 
                165                 170                 175     


Arg Asp Leu Tyr Ser Ala Leu Ile Gln Phe Phe Gln Ile Phe Pro Glu 
            180                 185                 190         


Tyr Lys Asn Asn Asp Phe Tyr Val Thr Gly Glu Ser Tyr Ala Gly Lys 
        195                 200                 205             


Tyr Val Pro Ala Ile Ala His Leu Ile His Ser Leu Asn Pro Val Arg 
    210                 215                 220                 


Glu Val Lys Ile Asn Leu Asn Gly Ile Ala Ile Gly Asp Gly Tyr Ser 
225                 230                 235                 240 


Asp Pro Glu Ser Ile Ile Gly Gly Tyr Ala Glu Phe Leu Tyr Gln Ile 
                245                 250                 255     


Gly Leu Leu Asp Glu Lys Gln Lys Lys Tyr Phe Gln Lys Gln Cys His 
            260                 265                 270         


Glu Cys Ile Glu His Ile Arg Lys Gln Asn Trp Phe Glu Ala Phe Glu 
        275                 280                 285             


Ile Leu Asp Lys Leu Leu Asp Gly Asp Leu Thr Ser Asp Pro Ser Tyr 
    290                 295                 300                 


Phe Gln Asn Val Thr Gly Cys Ser Asn Tyr Tyr Asn Phe Leu Arg Cys 
305                 310                 315                 320 


Thr Glu Pro Glu Asp Gln Leu Tyr Tyr Val Lys Phe Leu Ser Leu Pro 
                325                 330                 335     


Glu Val Arg Gln Ala Ile His Val Gly Asn Gln Thr Phe Asn Asp Gly 
            340                 345                 350         


Thr Ile Val Glu Lys Tyr Leu Arg Glu Asp Thr Val Gln Ser Val Lys 
        355                 360                 365             


Pro Trp Leu Thr Glu Ile Met Asn Asn Tyr Lys Val Leu Ile Tyr Asn 
    370                 375                 380                 


Gly Gln Leu Asp Ile Ile Val Ala Ala Ala Leu Thr Glu Arg Ser Leu 
385                 390                 395                 400 


Met Gly Met Asp Trp Lys Gly Ser Gln Glu Tyr Lys Lys Ala Glu Lys 
                405                 410                 415     


Lys Val Trp Lys Ile Phe Lys Ser Asp Ser Glu Val Ala Gly Tyr Ile 
            420                 425                 430         


Arg Gln Ala Gly Asp Phe His Gln Val Ile Ile Arg Gly Gly Gly His 
        435                 440                 445             


Ile Leu Pro Tyr Asp Gln Pro Leu Arg Ala Phe Asp Met Ile Asn Arg 
    450                 455                 460                 


Phe Ile Tyr Gly Lys Gly Trp Asp Pro Tyr Val Gly 
465                 470                 475     


<210>  3474
<211>  476
<212>  PRT
<213>  Homo Sapiens

<400>  3474

Met Val Gly Ala Met Trp Lys Val Ile Val Ser Leu Val Leu Leu Met 
1               5                   10                  15      


Pro Gly Pro Cys Asp Gly Leu Phe Arg Ser Leu Tyr Arg Ser Val Ser 
            20                  25                  30          


Met Pro Pro Lys Gly Asp Ser Gly Gln Pro Leu Phe Leu Thr Pro Tyr 
        35                  40                  45              


Ile Glu Ala Gly Lys Ile Gln Lys Gly Arg Glu Leu Ser Leu Val Gly 
    50                  55                  60                  


Pro Phe Pro Gly Leu Asn Met Lys Ser Tyr Ala Gly Phe Leu Thr Val 
65                  70                  75                  80  


Asn Lys Thr Tyr Asn Ser Asn Leu Phe Phe Trp Phe Phe Pro Ala Gln 
                85                  90                  95      


Ile Gln Pro Glu Asp Ala Pro Val Val Leu Trp Leu Gln Gly Gly Pro 
            100                 105                 110         


Gly Gly Ser Ser Met Phe Gly Leu Phe Val Glu His Gly Pro Tyr Val 
        115                 120                 125             


Val Thr Ser Asn Met Thr Leu Arg Asp Arg Asp Phe Pro Trp Thr Thr 
    130                 135                 140                 


Thr Leu Ser Met Leu Tyr Ile Asp Asn Pro Val Gly Thr Gly Phe Ser 
145                 150                 155                 160 


Phe Thr Asp Asp Thr His Gly Tyr Ala Val Asn Glu Asp Asp Val Ala 
                165                 170                 175     


Arg Asp Leu Tyr Ser Ala Leu Ile Gln Phe Phe Gln Ile Phe Pro Glu 
            180                 185                 190         


Tyr Lys Asn Asn Asp Phe Tyr Val Thr Gly Glu Ser Tyr Ala Gly Lys 
        195                 200                 205             


Tyr Val Pro Ala Ile Ala His Leu Ile His Ser Leu Asn Pro Val Arg 
    210                 215                 220                 


Glu Val Lys Ile Asn Leu Asn Gly Ile Ala Ile Gly Asp Gly Tyr Ser 
225                 230                 235                 240 


Asp Pro Glu Ser Ile Ile Gly Gly Tyr Ala Glu Phe Leu Tyr Gln Ile 
                245                 250                 255     


Gly Leu Leu Asp Glu Lys Gln Lys Lys Tyr Phe Gln Lys Gln Cys His 
            260                 265                 270         


Glu Cys Ile Glu His Ile Arg Lys Gln Asn Trp Phe Glu Ala Phe Glu 
        275                 280                 285             


Ile Leu Asp Lys Leu Leu Asp Gly Asp Leu Thr Ser Asp Pro Ser Tyr 
    290                 295                 300                 


Phe Gln Asn Val Thr Gly Cys Ser Asn Tyr Tyr Asn Phe Leu Arg Cys 
305                 310                 315                 320 


Thr Glu Pro Glu Asp Gln Leu Tyr Tyr Val Lys Phe Leu Ser Leu Pro 
                325                 330                 335     


Glu Val Arg Gln Ala Ile His Val Gly Asn Gln Thr Phe Asn Asp Gly 
            340                 345                 350         


Thr Ile Val Glu Lys Tyr Leu Arg Glu Asp Thr Val Gln Ser Val Lys 
        355                 360                 365             


Pro Trp Leu Thr Glu Ile Met Asn Asn Tyr Lys Val Leu Ile Tyr Asn 
    370                 375                 380                 


Gly Gln Leu Asp Ile Ile Val Ala Ala Ala Leu Thr Glu Arg Ser Leu 
385                 390                 395                 400 


Met Gly Met Asp Trp Lys Gly Ser Gln Glu Tyr Lys Lys Ala Glu Lys 
                405                 410                 415     


Lys Val Trp Lys Ile Phe Lys Ser Asp Ser Glu Val Ala Gly Tyr Ile 
            420                 425                 430         


Arg Gln Ala Gly Asp Phe His Gln Val Ile Ile Arg Gly Gly Gly His 
        435                 440                 445             


Ile Leu Pro Tyr Asp Gln Pro Leu Arg Ala Phe Asp Met Ile Asn Arg 
    450                 455                 460                 


Phe Ile Tyr Gly Lys Gly Trp Asp Pro Tyr Val Gly 
465                 470                 475     


<210>  3475
<211>  180
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3475

Xaa Lys Tyr Phe Gln Lys Gln Cys His Glu Cys Ile Glu His Ile Arg 
1               5                   10                  15      


Lys Gln Asn Trp Phe Glu Ala Phe Glu Glu Pro Glu Asp Gln Leu Tyr 
            20                  25                  30          


Tyr Val Lys Phe Leu Ser Leu Pro Glu Val Arg Gln Ala Ile His Val 
        35                  40                  45              


Gly Asn Gln Thr Phe Asn Asp Gly Thr Ile Val Glu Lys Tyr Leu Arg 
    50                  55                  60                  


Glu Asp Thr Val Gln Ser Val Lys Pro Trp Leu Thr Glu Ile Met Asn 
65                  70                  75                  80  


Asn Tyr Lys Val Leu Ile Tyr Asn Gly Gln Leu Asp Ile Ile Val Ala 
                85                  90                  95      


Ala Ala Leu Thr Glu Arg Ser Leu Met Gly Met Asp Trp Lys Gly Ser 
            100                 105                 110         


Gln Glu Tyr Lys Lys Ala Glu Lys Lys Val Trp Lys Ile Phe Lys Ser 
        115                 120                 125             


Asp Ser Glu Val Ala Gly Tyr Ile Arg Gln Ala Gly Asp Phe His Gln 
    130                 135                 140                 


Val Ile Ile Arg Gly Gly Gly His Ile Leu Pro Tyr Asp Gln Pro Leu 
145                 150                 155                 160 


Arg Ala Phe Asp Met Ile Asn Arg Phe Ile Tyr Gly Lys Gly Trp Asp 
                165                 170                 175     


Pro Tyr Val Gly 
            180 


<210>  3476
<211>  734
<212>  PRT
<213>  Homo Sapiens

<400>  3476

Met Trp Gly Leu Leu Leu Ala Leu Ala Ala Phe Ala Pro Ala Val Gly 
1               5                   10                  15      


Pro Ala Leu Gly Ala Pro Arg Asn Ser Val Leu Gly Leu Ala Gln Pro 
            20                  25                  30          


Gly Thr Thr Lys Val Pro Gly Ser Thr Pro Ala Leu His Ser Ser Pro 
        35                  40                  45              


Ala Gln Pro Pro Ala Glu Thr Ala Asn Gly Thr Ser Glu Gln His Val 
    50                  55                  60                  


Arg Ile Arg Val Ile Lys Lys Lys Lys Val Ile Met Lys Lys Arg Lys 
65                  70                  75                  80  


Lys Leu Thr Leu Thr Arg Pro Thr Pro Leu Val Thr Ala Gly Pro Leu 
                85                  90                  95      


Val Thr Pro Thr Pro Ala Gly Thr Leu Asp Pro Ala Glu Lys Gln Glu 
            100                 105                 110         


Thr Gly Cys Pro Pro Leu Gly Leu Glu Ser Leu Arg Val Ser Asp Ser 
        115                 120                 125             


Arg Leu Glu Ala Ser Ser Ser Gln Ser Phe Gly Leu Gly Pro His Arg 
    130                 135                 140                 


Gly Arg Leu Asn Ile Gln Ser Gly Leu Glu Asp Gly Asp Leu Tyr Asp 
145                 150                 155                 160 


Gly Ala Trp Cys Ala Glu Glu Gln Asp Ala Asp Pro Trp Phe Gln Val 
                165                 170                 175     


Asp Ala Gly His Pro Thr Arg Phe Ser Gly Val Ile Thr Gln Gly Arg 
            180                 185                 190         


Asn Ser Val Trp Arg Tyr Asp Trp Val Thr Ser Tyr Lys Val Gln Phe 
        195                 200                 205             


Ser Asn Asp Ser Arg Thr Trp Trp Gly Ser Arg Asn His Ser Ser Gly 
    210                 215                 220                 


Met Asp Ala Val Phe Pro Ala Asn Ser Asp Pro Glu Thr Pro Val Leu 
225                 230                 235                 240 


Asn Leu Leu Pro Glu Pro Gln Val Ala Arg Phe Ile Arg Leu Leu Pro 
                245                 250                 255     


Gln Thr Trp Leu Gln Gly Gly Ala Pro Cys Leu Arg Ala Glu Ile Leu 
            260                 265                 270         


Ala Cys Pro Val Ser Asp Pro Asn Asp Leu Phe Leu Glu Ala Pro Ala 
        275                 280                 285             


Ser Gly Ser Ser Asp Pro Leu Asp Phe Gln His His Asn Tyr Lys Ala 
    290                 295                 300                 


Met Arg Lys Leu Met Lys Gln Val Gln Glu Gln Cys Pro Asn Ile Thr 
305                 310                 315                 320 


Arg Ile Tyr Ser Ile Gly Lys Ser Tyr Gln Gly Leu Lys Leu Tyr Val 
                325                 330                 335     


Met Glu Met Ser Asp Lys Pro Gly Glu His Glu Leu Gly Glu Pro Glu 
            340                 345                 350         


Val Arg Tyr Val Ala Gly Met His Gly Asn Glu Ala Leu Gly Arg Glu 
        355                 360                 365             


Leu Leu Leu Leu Leu Met Gln Phe Leu Cys His Glu Phe Leu Arg Gly 
    370                 375                 380                 


Asn Pro Arg Val Thr Arg Leu Leu Ser Glu Met Arg Ile His Leu Leu 
385                 390                 395                 400 


Pro Ser Met Asn Pro Asp Gly Tyr Glu Ile Ala Tyr His Arg Gly Ser 
                405                 410                 415     


Glu Leu Val Gly Trp Ala Glu Gly Arg Trp Asn Asn Gln Ser Ile Asp 
            420                 425                 430         


Leu Asn His Asn Phe Ala Asp Leu Asn Thr Pro Leu Trp Glu Ala Gln 
        435                 440                 445             


Asp Asp Gly Lys Val Pro His Ile Val Pro Asn His His Leu Pro Leu 
    450                 455                 460                 


Pro Thr Tyr Tyr Thr Leu Pro Asn Ala Thr Val Ala Pro Glu Thr Arg 
465                 470                 475                 480 


Ala Val Ile Lys Trp Met Lys Arg Ile Pro Phe Val Leu Ser Ala Asn 
                485                 490                 495     


Leu His Gly Gly Glu Leu Val Val Ser Tyr Pro Phe Asp Met Thr Arg 
            500                 505                 510         


Thr Pro Trp Ala Ala Arg Glu Leu Thr Pro Thr Pro Asp Asp Ala Val 
        515                 520                 525             


Phe Arg Trp Leu Ser Thr Val Tyr Ala Gly Ser Asn Leu Ala Met Gln 
    530                 535                 540                 


Asp Thr Ser Arg Arg Pro Cys His Ser Gln Asp Phe Ser Val His Gly 
545                 550                 555                 560 


Asn Ile Ile Asn Gly Ala Asp Trp His Thr Val Pro Gly Ser Met Asn 
                565                 570                 575     


Asp Phe Ser Tyr Leu His Thr Asn Cys Phe Glu Val Thr Val Glu Leu 
            580                 585                 590         


Ser Cys Asp Lys Phe Pro His Glu Asn Glu Leu Pro Gln Glu Trp Glu 
        595                 600                 605             


Asn Asn Lys Asp Ala Leu Leu Thr Tyr Leu Glu Gln Val Arg Met Gly 
    610                 615                 620                 


Ile Ala Gly Val Val Arg Asp Lys Asp Thr Glu Leu Gly Ile Ala Asp 
625                 630                 635                 640 


Ala Val Ile Ala Val Asp Gly Ile Asn His Asp Val Thr Thr Ala Trp 
                645                 650                 655     


Gly Gly Asp Tyr Trp Arg Leu Leu Thr Pro Gly Asp Tyr Met Val Thr 
            660                 665                 670         


Ala Ser Ala Glu Gly Tyr His Ser Val Thr Arg Asn Cys Arg Val Thr 
        675                 680                 685             


Phe Glu Glu Gly Pro Phe Pro Cys Asn Phe Val Leu Thr Lys Thr Pro 
    690                 695                 700                 


Lys Gln Arg Leu Arg Glu Leu Leu Ala Ala Gly Ala Lys Val Pro Pro 
705                 710                 715                 720 


Asp Leu Arg Arg Arg Leu Glu Arg Leu Arg Gly Gln Lys Asp 
                725                 730                 


<210>  3477
<211>  224
<212>  PRT
<213>  Homo Sapiens

<400>  3477

Met Glu Lys Ile Pro Phe Val Leu Gly Gly Asn Leu Gln Gly Gly Glu 
1               5                   10                  15      


Leu Val Val Ala Tyr Pro Tyr Asp Leu Val Arg Ser Pro Trp Lys Thr 
            20                  25                  30          


Gln Glu His Thr Pro Thr Pro Asp Asp His Val Phe Arg Trp Leu Ala 
        35                  40                  45              


Tyr Ser Tyr Ala Ser Thr His Arg Leu Met Thr Asp Ala Arg Arg Arg 
    50                  55                  60                  


Val Cys His Thr Glu Asp Phe Gln Lys Glu Glu Gly Thr Val Asn Gly 
65                  70                  75                  80  


Ala Ser Trp His Thr Val Ala Gly Ser Leu Asn Asp Phe Ser Tyr Leu 
                85                  90                  95      


His Thr Asn Cys Phe Glu Leu Ser Ile Tyr Val Gly Cys Asp Lys Tyr 
            100                 105                 110         


Pro His Glu Ser Gln Leu Pro Glu Glu Trp Glu Asn Asn Arg Glu Ser 
        115                 120                 125             


Leu Ile Val Phe Met Glu Gln Val His Arg Gly Ile Lys Gly Leu Val 
    130                 135                 140                 


Arg Asp Ser His Gly Lys Gly Ile Pro Asn Ala Ile Ile Ser Val Glu 
145                 150                 155                 160 


Gly Ile Asn His Asp Ile Arg Thr Gly Arg Val Ser Leu Gln Lys Leu 
                165                 170                 175     


Ser Leu Ala Cys Arg Arg Val Arg Cys Ala Phe Ala Leu Ser Ser Ser 
            180                 185                 190         


Ser Thr Met Ile Val Arg Pro Pro Gln Pro Tyr Gly Thr Val Pro His 
        195                 200                 205             


Ser Ser Pro Asp Pro Val Thr Thr Lys Ile Ser Pro Leu Arg Asn Phe 
    210                 215                 220                 


<210>  3478
<211>  756
<212>  PRT
<213>  Homo Sapiens

<400>  3478

Met Ser Arg Pro Gly Thr Ala Thr Pro Ala Leu Ala Leu Val Leu Leu 
1               5                   10                  15      


Ala Val Thr Leu Ala Gly Val Gly Ala Gln Gly Ala Ala Leu Glu Asp 
            20                  25                  30          


Pro Asp Tyr Tyr Gly Gln Glu Ile Trp Ser Arg Glu Pro Tyr Tyr Ala 
        35                  40                  45              


Arg Pro Glu Pro Glu Leu Glu Thr Phe Ser Pro Pro Leu Pro Ala Gly 
    50                  55                  60                  


Pro Gly Glu Glu Trp Glu Arg Arg Pro Gln Glu Pro Arg Pro Pro Lys 
65                  70                  75                  80  


Arg Ala Thr Lys Pro Lys Lys Ala Pro Lys Arg Glu Lys Ser Ala Pro 
                85                  90                  95      


Glu Pro Pro Pro Pro Gly Lys His Ser Asn Lys Lys Val Met Arg Thr 
            100                 105                 110         


Lys Ser Ser Glu Lys Ala Ala Asn Asp Asp His Ser Val Arg Val Ala 
        115                 120                 125             


Arg Glu Asp Val Arg Glu Ser Cys Pro Pro Leu Gly Leu Glu Thr Leu 
    130                 135                 140                 


Lys Ile Thr Asp Phe Gln Leu His Ala Ser Thr Val Lys Arg Tyr Gly 
145                 150                 155                 160 


Leu Gly Ala His Arg Gly Arg Leu Asn Ile Gln Ala Gly Ile Asn Glu 
                165                 170                 175     


Asn Asp Phe Tyr Asp Gly Ala Trp Cys Ala Gly Arg Asn Asp Leu Gln 
            180                 185                 190         


Gln Trp Ile Glu Val Asp Ala Arg Arg Leu Thr Arg Phe Thr Gly Val 
        195                 200                 205             


Ile Thr Gln Gly Arg Asn Ser Leu Trp Leu Ser Asp Trp Val Thr Ser 
    210                 215                 220                 


Tyr Lys Val Met Val Ser Asn Asp Ser His Thr Trp Val Thr Val Lys 
225                 230                 235                 240 


Asn Gly Ser Gly Asp Met Ile Phe Glu Gly Asn Ser Glu Lys Glu Ile 
                245                 250                 255     


Pro Val Leu Asn Glu Leu Pro Val Pro Met Val Ala Arg Tyr Ile Arg 
            260                 265                 270         


Ile Asn Pro Gln Ser Trp Phe Asp Asn Gly Ser Ile Cys Met Arg Met 
        275                 280                 285             


Glu Ile Leu Gly Cys Pro Leu Pro Asp Pro Asn Asn Tyr Tyr His Arg 
    290                 295                 300                 


Arg Asn Glu Met Thr Thr Thr Asp Asp Leu Asp Phe Lys His His Asn 
305                 310                 315                 320 


Tyr Lys Glu Met Arg Gln Leu Met Lys Val Val Asn Glu Met Cys Pro 
                325                 330                 335     


Asn Ile Thr Arg Ile Tyr Asn Ile Gly Lys Ser His Gln Gly Leu Lys 
            340                 345                 350         


Leu Tyr Ala Val Glu Ile Ser Asp His Pro Gly Glu His Glu Val Gly 
        355                 360                 365             


Glu Pro Glu Phe His Tyr Ile Ala Gly Ala His Gly Asn Glu Val Leu 
    370                 375                 380                 


Gly Arg Glu Leu Leu Leu Leu Leu Val Gln Phe Val Cys Gln Glu Tyr 
385                 390                 395                 400 


Leu Ala Arg Asn Ala Arg Ile Val His Leu Val Glu Glu Thr Arg Ile 
                405                 410                 415     


His Val Leu Pro Ser Leu Asn Pro Asp Gly Tyr Glu Lys Ala Tyr Glu 
            420                 425                 430         


Gly Gly Ser Glu Leu Gly Gly Trp Ser Leu Gly Arg Trp Thr His Asp 
        435                 440                 445             


Gly Ile Asp Ile Asn Asn Asn Phe Pro Asp Leu Asn Thr Leu Leu Trp 
    450                 455                 460                 


Glu Ala Glu Asp Arg Gln Asn Val Pro Arg Lys Val Pro Asn His Tyr 
465                 470                 475                 480 


Ile Ala Ile Pro Glu Trp Phe Leu Ser Glu Asn Ala Thr Val Ala Ala 
                485                 490                 495     


Glu Thr Arg Ala Val Ile Ala Trp Met Glu Lys Ile Pro Phe Val Leu 
            500                 505                 510         


Gly Gly Asn Leu Gln Gly Gly Glu Leu Val Val Ala Tyr Pro Tyr Asp 
        515                 520                 525             


Leu Val Arg Ser Pro Trp Lys Thr Gln Glu His Thr Pro Thr Pro Asp 
    530                 535                 540                 


Asp His Val Phe Arg Trp Leu Ala Tyr Ser Tyr Ala Ser Thr His Arg 
545                 550                 555                 560 


Leu Met Thr Asp Ala Arg Arg Arg Val Cys His Thr Glu Asp Phe Gln 
                565                 570                 575     


Lys Glu Glu Gly Thr Val Asn Gly Ala Ser Trp His Thr Val Ala Gly 
            580                 585                 590         


Ser Leu Asn Asp Phe Ser Tyr Leu His Thr Asn Cys Phe Glu Leu Ser 
        595                 600                 605             


Ile Tyr Val Gly Cys Asp Lys Tyr Pro His Glu Ser Gln Leu Pro Glu 
    610                 615                 620                 


Glu Trp Glu Asn Asn Arg Glu Ser Leu Ile Val Phe Met Glu Gln Val 
625                 630                 635                 640 


His Arg Gly Ile Lys Gly Leu Val Arg Asp Ser His Gly Lys Gly Ile 
                645                 650                 655     


Pro Asn Ala Ile Ile Ser Val Glu Gly Ile Asn His Asp Ile Arg Thr 
            660                 665                 670         


Ala Asn Asp Gly Asp Tyr Trp Arg Leu Leu Asn Pro Gly Glu Tyr Val 
        675                 680                 685             


Val Thr Ala Lys Ala Glu Gly Phe Thr Ala Ser Thr Lys Asn Cys Met 
    690                 695                 700                 


Val Gly Tyr Asp Met Gly Ala Thr Arg Cys Asp Phe Thr Leu Ser Lys 
705                 710                 715                 720 


Thr Asn Met Ala Arg Ile Arg Glu Ile Met Glu Lys Phe Gly Lys Gln 
                725                 730                 735     


Pro Val Ser Leu Pro Ala Arg Arg Leu Lys Leu Arg Gly Gln Lys Arg 
            740                 745                 750         


Arg Gln Arg Gly 
        755     


<210>  3479
<211>  515
<212>  PRT
<213>  Homo Sapiens

<400>  3479

Met Ala Trp Pro Tyr Phe Leu Asp Cys His Arg Tyr Phe Thr Arg Glu 
1               5                   10                  15      


Asp Glu Gly Cys Tyr Asp Pro Leu Glu Lys Leu Arg Gly Gly Leu Glu 
            20                  25                  30          


Ala Asp Glu Ala Leu Pro Ser Gly Leu Pro Pro Thr Phe Ile Arg Phe 
        35                  40                  45              


Ser His His Ser Tyr Ala Gln Met Val Arg Val Leu Arg Arg Thr Ala 
    50                  55                  60                  


Ser Arg Cys Ala His Val Ala Arg Thr Tyr Ser Ile Gly Arg Ser Phe 
65                  70                  75                  80  


Asp Gly Arg Glu Leu Leu Val Ile Glu Phe Ser Ser Arg Pro Gly Gln 
                85                  90                  95      


His Glu Leu Met Glu Pro Glu Val Lys Leu Ile Gly Asn Ile His Gly 
            100                 105                 110         


Asn Glu Val Ala Gly Arg Glu Met Leu Ile Tyr Leu Ala Gln Tyr Leu 
        115                 120                 125             


Cys Ser Glu Tyr Leu Leu Gly Asn Pro Arg Ile Gln Arg Leu Leu Asn 
    130                 135                 140                 


Thr Thr Arg Ile His Leu Leu Pro Ser Met Asn Pro Asp Gly Tyr Glu 
145                 150                 155                 160 


Val Ala Ala Ala Glu Gly Ala Gly Tyr Asn Gly Trp Thr Ser Gly Arg 
                165                 170                 175     


Gln Asn Ala Gln Asn Leu Asp Leu Asn Arg Asn Phe Pro Asp Leu Thr 
            180                 185                 190         


Ser Glu Tyr Tyr Arg Leu Ala Glu Thr Arg Gly Ala Arg Ser Asp His 
        195                 200                 205             


Ile Pro Ile Pro Gln His Tyr Trp Trp Gly Lys Val Ala Pro Glu Thr 
    210                 215                 220                 


Lys Ala Ile Met Lys Trp Met Gln Thr Ile Pro Phe Val Leu Ser Ala 
225                 230                 235                 240 


Ser Leu His Gly Gly Asp Leu Val Val Ser Tyr Pro Phe Asp Phe Ser 
                245                 250                 255     


Lys His Pro Gln Glu Glu Lys Met Phe Ser Pro Thr Pro Asp Glu Lys 
            260                 265                 270         


Met Phe Lys Leu Leu Ser Arg Ala Tyr Ala Asp Val His Pro Met Met 
        275                 280                 285             


Met Asp Arg Ser Glu Asn Arg Cys Gly Gly Asn Phe Leu Lys Arg Gly 
    290                 295                 300                 


Ser Ile Ile Asn Gly Ala Asp Trp Tyr Ser Phe Thr Gly Gly Met Ser 
305                 310                 315                 320 


Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Val Glu Leu 
                325                 330                 335     


Gly Cys Val Lys Phe Pro Pro Glu Glu Ala Leu Tyr Ile Leu Trp Gln 
            340                 345                 350         


His Asn Lys Glu Ser Leu Leu Asn Phe Val Glu Thr Val His Arg Gly 
        355                 360                 365             


Ile Lys Gly Val Val Thr Asp Lys Phe Gly Lys Pro Val Lys Asn Ala 
    370                 375                 380                 


Arg Ile Ser Val Lys Gly Ile Arg His Asp Ile Thr Thr Ala Pro Asp 
385                 390                 395                 400 


Gly Asp Tyr Trp Arg Leu Leu Pro Pro Gly Ile His Ile Val Ile Ala 
                405                 410                 415     


Gln Ala Pro Gly Tyr Ala Lys Val Ile Lys Lys Val Ile Ile Pro Ala 
            420                 425                 430         


Arg Met Lys Arg Ala Gly Arg Val Asp Phe Ile Leu Gln Pro Leu Gly 
        435                 440                 445             


Met Gly Pro Lys Asn Phe Ile His Gly Leu Arg Arg Thr Gly Pro His 
    450                 455                 460                 


Asp Pro Leu Gly Gly Ala Ser Ser Leu Gly Glu Ala Thr Glu Pro Asp 
465                 470                 475                 480 


Pro Leu Arg Ala Arg Arg Gln Pro Ser Ala Asp Gly Ser Lys Pro Trp 
                485                 490                 495     


Trp Trp Ser Tyr Phe Thr Ser Leu Ser Thr His Arg Pro Arg Trp Leu 
            500                 505                 510         


Leu Lys Tyr 
        515 


<210>  3480
<211>  641
<212>  PRT
<213>  Homo Sapiens

<400>  3480

Met Pro Pro Pro Leu Pro Leu Leu Leu Leu Thr Val Leu Val Val Ala 
1               5                   10                  15      


Ala Ala Arg Pro Gly Cys Glu Phe Glu Arg Asn Pro Ala Ala Thr Cys 
            20                  25                  30          


Val Asp Leu Gln Leu Arg Thr Cys Ser Asp Ala Ala Tyr Asn His Thr 
        35                  40                  45              


Thr Phe Pro Asn Leu Leu Gln His Arg Ser Trp Glu Val Val Glu Ala 
    50                  55                  60                  


Ser Ser Glu Tyr Ile Leu Leu Ser Val Leu His Gln Leu Leu Glu Gly 
65                  70                  75                  80  


Gln Cys Asn Pro Asp Leu Arg Leu Leu Gly Cys Ala Val Leu Ala Pro 
                85                  90                  95      


Arg Cys Glu Gly Gly Trp Val Arg Arg Pro Cys Arg His Ile Cys Glu 
            100                 105                 110         


Gly Leu Arg Glu Val Cys Gln Pro Ala Phe Asp Ala Ile Asp Met Ala 
        115                 120                 125             


Trp Pro Tyr Phe Leu Asp Cys His Arg Tyr Phe Thr Arg Glu Asp Glu 
    130                 135                 140                 


Gly Cys Tyr Asp Pro Leu Glu Lys Leu Arg Gly Gly Leu Glu Ala Asp 
145                 150                 155                 160 


Glu Ala Leu Pro Ser Gly Leu Pro Pro Thr Phe Ile Arg Phe Ser His 
                165                 170                 175     


His Ser Tyr Ala Gln Met Val Arg Val Leu Arg Arg Thr Ala Ser Arg 
            180                 185                 190         


Cys Ala His Val Ala Arg Thr Tyr Ser Ile Gly Arg Ser Phe Asp Gly 
        195                 200                 205             


Arg Glu Leu Leu Val Ile Glu Phe Ser Ser Arg Pro Gly Gln His Glu 
    210                 215                 220                 


Leu Met Glu Pro Glu Val Lys Leu Ile Gly Asn Ile His Gly Asn Glu 
225                 230                 235                 240 


Val Ala Gly Arg Glu Met Leu Ile Tyr Leu Ala Gln Tyr Leu Cys Ser 
                245                 250                 255     


Glu Tyr Leu Leu Gly Asn Pro Arg Ile Gln Arg Leu Leu Asn Thr Thr 
            260                 265                 270         


Arg Ile His Leu Leu Pro Ser Met Asn Pro Asp Gly Tyr Glu Val Ala 
        275                 280                 285             


Ala Ala Glu Gly Ala Gly Tyr Asn Gly Trp Thr Ser Gly Arg Gln Asn 
    290                 295                 300                 


Ala Gln Asn Leu Asp Leu Asn Arg Asn Phe Pro Asp Leu Thr Ser Glu 
305                 310                 315                 320 


Tyr Tyr Arg Leu Ala Glu Thr Arg Gly Ala Arg Ser Asp His Ile Pro 
                325                 330                 335     


Ile Pro Gln His Tyr Trp Trp Gly Lys Val Ala Pro Glu Thr Lys Ala 
            340                 345                 350         


Ile Met Lys Trp Met Gln Thr Ile Pro Phe Val Leu Ser Ala Ser Leu 
        355                 360                 365             


His Gly Gly Asp Leu Val Val Ser Tyr Pro Phe Asp Phe Ser Lys His 
    370                 375                 380                 


Pro Gln Glu Glu Lys Met Phe Ser Pro Thr Pro Asp Glu Lys Met Phe 
385                 390                 395                 400 


Lys Leu Leu Ser Arg Ala Tyr Ala Asp Val His Pro Met Met Met Asp 
                405                 410                 415     


Arg Ser Glu Asn Arg Cys Gly Gly Asn Phe Leu Lys Arg Gly Ser Ile 
            420                 425                 430         


Ile Asn Gly Ala Asp Trp Tyr Ser Phe Thr Gly Gly Met Ser Asp Phe 
        435                 440                 445             


Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr Val Glu Leu Gly Cys 
    450                 455                 460                 


Val Lys Phe Pro Pro Glu Glu Ala Leu Tyr Ile Leu Trp Gln His Asn 
465                 470                 475                 480 


Lys Glu Ser Leu Leu Asn Phe Val Glu Thr Val His Arg Gly Ile Lys 
                485                 490                 495     


Gly Val Val Thr Asp Lys Phe Gly Lys Pro Val Lys Asn Ala Arg Ile 
            500                 505                 510         


Ser Val Lys Gly Ile Arg His Asp Ile Thr Thr Ala Pro Asp Gly Asp 
        515                 520                 525             


Tyr Trp Arg Leu Leu Pro Pro Gly Ile His Ile Val Ile Ala Gln Ala 
    530                 535                 540                 


Pro Gly Tyr Ala Lys Val Ile Lys Lys Val Ile Ile Pro Ala Arg Met 
545                 550                 555                 560 


Lys Arg Ala Gly Arg Val Asp Phe Ile Leu Gln Pro Leu Gly Met Gly 
                565                 570                 575     


Pro Lys Asn Phe Ile His Gly Leu Arg Arg Thr Gly Pro His Asp Pro 
            580                 585                 590         


Leu Gly Gly Ala Ser Ser Leu Gly Glu Ala Thr Glu Pro Asp Pro Leu 
        595                 600                 605             


Arg Ala Arg Arg Gln Pro Ser Ala Asp Gly Ser Lys Pro Trp Trp Trp 
    610                 615                 620                 


Ser Tyr Phe Thr Ser Leu Ser Thr His Arg Pro Arg Trp Leu Leu Lys 
625                 630                 635                 640 


Tyr 
    


<210>  3481
<211>  652
<212>  PRT
<213>  Homo Sapiens

<400>  3481

Met Pro Pro Pro Leu Pro Leu Leu Leu Leu Thr Val Leu Val Val Ala 
1               5                   10                  15      


Ala Ala Arg Pro Gly Cys Glu Phe Glu Arg Asn Pro Ala Gly Glu Cys 
            20                  25                  30          


His Arg Pro Pro Ala Ala Asp Ser Ala Thr Cys Val Asp Leu Gln Leu 
        35                  40                  45              


Arg Thr Cys Ser Asp Ala Ala Tyr Asn His Thr Thr Phe Pro Asn Leu 
    50                  55                  60                  


Leu Gln His Arg Ser Trp Glu Val Val Glu Ala Ser Ser Glu Tyr Ile 
65                  70                  75                  80  


Leu Leu Ser Val Leu His Gln Leu Leu Glu Gly Gln Cys Asn Pro Asp 
                85                  90                  95      


Leu Arg Leu Leu Gly Cys Ala Val Leu Ala Pro Arg Cys Glu Gly Gly 
            100                 105                 110         


Trp Val Arg Arg Pro Cys Arg His Ile Cys Glu Gly Leu Arg Glu Val 
        115                 120                 125             


Cys Gln Pro Ala Phe Asp Ala Ile Asp Met Ala Trp Pro Tyr Phe Leu 
    130                 135                 140                 


Asp Cys His Arg Tyr Phe Thr Arg Glu Asp Glu Gly Cys Tyr Asp Pro 
145                 150                 155                 160 


Leu Glu Lys Leu Arg Gly Gly Leu Glu Ala Asp Glu Ala Leu Pro Ser 
                165                 170                 175     


Gly Leu Pro Pro Thr Phe Ile Arg Phe Ser His His Ser Tyr Ala Gln 
            180                 185                 190         


Met Val Arg Val Leu Arg Arg Thr Ala Ser Arg Cys Ala His Val Ala 
        195                 200                 205             


Arg Thr Tyr Ser Ile Gly Arg Ser Phe Asp Gly Arg Glu Leu Leu Val 
    210                 215                 220                 


Ile Glu Phe Ser Ser Arg Pro Gly Gln His Glu Leu Met Glu Pro Glu 
225                 230                 235                 240 


Val Lys Leu Ile Gly Asn Ile His Gly Asn Glu Val Ala Gly Arg Glu 
                245                 250                 255     


Met Leu Ile Tyr Leu Ala Gln Tyr Leu Cys Ser Glu Tyr Leu Leu Gly 
            260                 265                 270         


Asn Pro Arg Ile Gln Arg Leu Leu Asn Thr Thr Arg Ile His Leu Leu 
        275                 280                 285             


Pro Ser Met Asn Pro Asp Gly Tyr Glu Val Ala Ala Ala Glu Gly Ala 
    290                 295                 300                 


Gly Tyr Asn Gly Trp Thr Ser Gly Arg Gln Asn Ala Gln Asn Leu Asp 
305                 310                 315                 320 


Leu Asn Arg Asn Phe Pro Asp Leu Thr Ser Glu Tyr Tyr Arg Leu Ala 
                325                 330                 335     


Glu Thr Arg Gly Ala Arg Ser Asp His Ile Pro Ile Pro Gln His Tyr 
            340                 345                 350         


Trp Trp Gly Lys Val Ala Pro Glu Thr Lys Ala Ile Met Lys Trp Met 
        355                 360                 365             


Gln Thr Ile Pro Phe Val Leu Ser Ala Ser Leu His Gly Gly Asp Leu 
    370                 375                 380                 


Val Val Ser Tyr Pro Phe Asp Phe Ser Lys His Pro Gln Glu Glu Lys 
385                 390                 395                 400 


Met Phe Ser Pro Thr Pro Asp Glu Lys Met Phe Lys Leu Leu Ser Arg 
                405                 410                 415     


Ala Tyr Ala Asp Val His Pro Met Met Met Asp Arg Ser Glu Asn Arg 
            420                 425                 430         


Cys Gly Gly Asn Phe Leu Lys Arg Gly Ser Ile Ile Asn Gly Ala Asp 
        435                 440                 445             


Trp Tyr Ser Phe Thr Gly Gly Met Ser Asp Phe Asn Tyr Leu His Thr 
    450                 455                 460                 


Asn Cys Phe Glu Ile Thr Val Glu Leu Gly Cys Val Lys Phe Pro Pro 
465                 470                 475                 480 


Glu Glu Ala Leu Tyr Ile Leu Trp Gln His Asn Lys Glu Ser Leu Leu 
                485                 490                 495     


Asn Phe Val Glu Thr Val His Arg Gly Ile Lys Gly Val Val Thr Asp 
            500                 505                 510         


Lys Phe Gly Lys Pro Val Lys Asn Ala Arg Ile Ser Val Lys Gly Ile 
        515                 520                 525             


Arg His Asp Ile Thr Thr Ala Pro Asp Gly Asp Tyr Trp Arg Leu Leu 
    530                 535                 540                 


Pro Pro Gly Ile His Ile Val Ile Ala Gln Ala Pro Gly Tyr Ala Lys 
545                 550                 555                 560 


Val Ile Lys Lys Val Ile Ile Pro Ala Arg Met Lys Arg Ala Gly Arg 
                565                 570                 575     


Val Asp Phe Ile Leu Gln Pro Leu Gly Met Gly Pro Lys Asn Phe Ile 
            580                 585                 590         


His Gly Leu Arg Arg Thr Gly Pro His Asp Pro Leu Gly Gly Ala Ser 
        595                 600                 605             


Ser Leu Gly Glu Ala Thr Glu Pro Asp Pro Leu Arg Ala Arg Arg Gln 
    610                 615                 620                 


Pro Ser Ala Asp Gly Ser Lys Pro Trp Trp Trp Ser Tyr Phe Thr Ser 
625                 630                 635                 640 


Leu Ser Thr His Arg Pro Arg Trp Leu Leu Lys Tyr 
                645                 650         


<210>  3482
<211>  69
<212>  PRT
<213>  Homo Sapiens

<400>  3482

Met Pro Pro Pro Leu Pro Leu Leu Leu Leu Thr Val Leu Val Val Ala 
1               5                   10                  15      


Ala Ala Arg Pro Gly Cys Glu Phe Glu Arg Asn Pro Ala Gly Glu Cys 
            20                  25                  30          


His Arg Pro Pro Ala Ala Asp Ser Gly Thr Val Pro Gly Pro Pro Trp 
        35                  40                  45              


Leu Leu Phe Cys Arg Arg Ala Ala Ala Pro Thr Leu Ser Glu His Phe 
    50                  55                  60                  


Arg Gln Leu Asn Pro 
65                  


<210>  3483
<211>  388
<212>  PRT
<213>  Homo Sapiens

<400>  3483

Ile Gly Thr Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg 
1               5                   10                  15      


Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Thr Ser Ala Lys 
            20                  25                  30          


Asp Lys Cys Lys Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn 
        35                  40                  45              


Gly Met Ala His Val Ile Lys Asp Ile Gln Phe Arg Ser Gln Ile Lys 
    50                  55                  60                  


Tyr Ser Cys Pro Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Thr 
65                  70                  75                  80  


Cys Ile Ile Ser Gly Asn Thr Val Ile Trp Asp Asn Lys Thr Pro Val 
                85                  90                  95      


Cys Asp Arg Ile Ile Cys Gly Leu Pro Pro Thr Ile Ala Asn Gly Asp 
            100                 105                 110         


Phe Thr Ser Ile Ser Arg Glu Tyr Phe His Tyr Gly Ser Val Val Thr 
        115                 120                 125             


Tyr His Cys Asn Leu Gly Ser Arg Gly Lys Lys Val Phe Glu Leu Val 
    130                 135                 140                 


Gly Glu Pro Ser Ile Tyr Cys Thr Ser Lys Asp Asp Gln Val Gly Ile 
145                 150                 155                 160 


Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro 
                165                 170                 175     


Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe 
            180                 185                 190         


Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Gly Met 
        195                 200                 205             


Lys Gly Pro Ser His Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro 
    210                 215                 220                 


Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu 
225                 230                 235                 240 


His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln 
                245                 250                 255     


Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ser Thr 
            260                 265                 270         


Tyr Leu His Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Arg 
        275                 280                 285             


Cys Glu Val Lys Ser Cys Asp Asp Phe Leu Gly Gln Leu Pro Asn Gly 
    290                 295                 300                 


His Val Leu Phe Pro Leu Asn Leu Gln Leu Gly Ala Lys Val Asp Phe 
305                 310                 315                 320 


Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys 
                325                 330                 335     


Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys 
            340                 345                 350         


Glu Arg Lys Ser Cys Glu Thr Pro Pro Val Pro Val Asn Gly Met Val 
        355                 360                 365             


His Val Ile Thr Asp Ile His Val Gly Ser Arg Ile Asn Tyr Ser Cys 
    370                 375                 380                 


Thr Thr Gly Phe 
385             


<210>  3484
<211>  569
<212>  PRT
<213>  Homo Sapiens

<400>  3484

Met Ala Pro Pro Val Arg Leu Glu Arg Pro Phe Pro Ser Arg Arg Phe 
1               5                   10                  15      


Pro Gly Leu Leu Leu Ala Ala Leu Val Leu Leu Leu Ser Ser Phe Ser 
            20                  25                  30          


Asp Gln Cys Asn Val Pro Glu Trp Leu Pro Phe Ala Arg Pro Thr Asn 
        35                  40                  45              


Leu Thr Asp Asp Phe Glu Phe Pro Ile Gly Thr Tyr Leu Asn Tyr Glu 
    50                  55                  60                  


Cys Arg Pro Gly Tyr Ser Gly Arg Pro Phe Ser Ile Ile Cys Leu Lys 
65                  70                  75                  80  


Asn Ser Val Trp Thr Ser Ala Lys Asp Lys Cys Lys Arg Lys Ser Cys 
                85                  90                  95      


Arg Asn Pro Pro Asp Pro Val Asn Gly Met Ala His Val Ile Lys Asp 
            100                 105                 110         


Ile Gln Phe Arg Ser Gln Ile Lys Tyr Ser Cys Pro Lys Gly Tyr Arg 
        115                 120                 125             


Leu Ile Gly Ser Ser Ser Ala Thr Cys Ile Ile Ser Gly Asn Thr Val 
    130                 135                 140                 


Ile Trp Asp Asn Lys Thr Pro Val Cys Asp Arg Ile Ile Cys Gly Leu 
145                 150                 155                 160 


Pro Pro Thr Ile Ala Asn Gly Asp Phe Thr Ser Ile Ser Arg Glu Tyr 
                165                 170                 175     


Phe His Tyr Gly Ser Val Val Thr Tyr His Cys Asn Leu Gly Ser Arg 
            180                 185                 190         


Gly Lys Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr 
        195                 200                 205             


Ser Lys Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys 
    210                 215                 220                 


Ile Ile Pro Asn Lys Cys Thr Pro Pro Asn Val Glu Asn Gly Ile Leu 
225                 230                 235                 240 


Val Ser Asp Asn Arg Ser Leu Phe Ser Leu Asn Glu Val Val Glu Phe 
                245                 250                 255     


Arg Cys Gln Pro Gly Phe Gly Met Lys Gly Pro Ser His Val Lys Cys 
            260                 265                 270         


Gln Ala Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser Cys Ser Arg Val 
        275                 280                 285             


Cys Gln Pro Pro Pro Asp Val Leu His Ala Glu Arg Thr Gln Arg Asp 
    290                 295                 300                 


Lys Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro 
305                 310                 315                 320 


Gly Tyr Asp Leu Arg Gly Ser Thr Tyr Leu His Cys Thr Pro Gln Gly 
                325                 330                 335     


Asp Trp Ser Pro Ala Ala Pro Arg Cys Glu Val Lys Ser Cys Asp Asp 
            340                 345                 350         


Phe Leu Gly Gln Leu Pro Asn Gly His Val Leu Phe Pro Leu Asn Leu 
        355                 360                 365             


Gln Leu Gly Ala Lys Val Asp Phe Val Cys Asp Glu Gly Phe Gln Leu 
    370                 375                 380                 


Lys Gly Ser Ser Ala Ser Tyr Cys Val Leu Ala Gly Met Glu Ser Leu 
385                 390                 395                 400 


Trp Asn Ser Ser Val Pro Val Cys Glu Arg Lys Ser Cys Glu Thr Pro 
                405                 410                 415     


Pro Val Pro Val Asn Gly Met Val His Val Ile Thr Asp Ile His Val 
            420                 425                 430         


Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly 
        435                 440                 445             


His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn Thr Ala His Trp Ser 
    450                 455                 460                 


Met Lys Pro Pro Ile Cys Gln Gln Ile Phe Cys Pro Asn Pro Pro Ala 
465                 470                 475                 480 


Ile Leu Asn Gly Arg His Thr Gly Thr Pro Leu Gly Asp Ile Pro Tyr 
                485                 490                 495     


Gly Lys Glu Val Ser Tyr Thr Cys Asp Pro His Pro Asp Arg Gly Met 
            500                 505                 510         


Thr Phe Asn Leu Ile Gly Glu Ser Thr Ile Arg Arg Thr Ser Glu Pro 
        515                 520                 525             


His Gly Asn Gly Val Trp Ser Ser Pro Ala Pro Arg Cys Glu Leu Pro 
    530                 535                 540                 


Val Gly Ala Gly Ser His Asp Ala Leu Ile Val Gly Lys Phe Tyr Glu 
545                 550                 555                 560 


Val Phe Ala Glu Glu Phe Cys His Leu 
                565                 


<210>  3485
<211>  1176
<212>  PRT
<213>  Homo Sapiens

<400>  3485

Met Ala Leu Ala Arg Pro Gly Thr Pro Asp Pro Gln Ala Leu Ala Ser 
1               5                   10                  15      


Val Leu Leu Leu Leu Leu Trp Ala Pro Ala Leu Ser Leu Leu Ala Gly 
            20                  25                  30          


Thr Val Pro Ser Glu Pro Pro Ser Ala Cys Ala Ser Asp Pro Cys Ala 
        35                  40                  45              


Pro Gly Thr Glu Cys Gln Ala Thr Glu Ser Gly Gly Tyr Thr Cys Gly 
    50                  55                  60                  


Pro Met Glu Pro Arg Gly Cys Ala Thr Gln Pro Cys His His Gly Ala 
65                  70                  75                  80  


Leu Cys Val Pro Gln Gly Pro Asp Pro Thr Gly Phe Arg Cys Tyr Cys 
                85                  90                  95      


Val Pro Gly Phe Gln Gly Pro Arg Cys Glu Leu Asp Ile Asp Glu Cys 
            100                 105                 110         


Ala Ser Arg Pro Cys His His Gly Ala Thr Cys Arg Asn Leu Ala Asp 
        115                 120                 125             


Arg Tyr Glu Cys His Cys Pro Leu Gly Tyr Ala Gly Val Thr Cys Glu 
    130                 135                 140                 


Met Glu Val Asp Glu Cys Ala Ser Ala Pro Cys Leu His Gly Gly Ser 
145                 150                 155                 160 


Cys Leu Asp Gly Val Gly Ser Phe Arg Cys Val Cys Ala Pro Gly Tyr 
                165                 170                 175     


Gly Gly Thr Arg Cys Gln Leu Asp Leu Asp Glu Cys Gln Ser Gln Pro 
            180                 185                 190         


Cys Ala His Gly Gly Thr Cys His Asp Leu Val Asn Gly Phe Arg Cys 
        195                 200                 205             


Asp Cys Ala Gly Thr Gly Tyr Glu Gly Thr His Cys Glu Arg Glu Val 
    210                 215                 220                 


Leu Glu Cys Ala Ser Ala Pro Cys Glu His Asn Ala Ser Cys Leu Glu 
225                 230                 235                 240 


Gly Leu Gly Ser Phe Arg Cys Leu Cys Trp Pro Gly Tyr Ser Gly Glu 
                245                 250                 255     


Leu Cys Glu Val Asp Glu Asp Glu Cys Ala Ser Ser Pro Cys Gln His 
            260                 265                 270         


Gly Gly Arg Cys Leu Gln Arg Ser Asp Pro Ala Leu Tyr Gly Gly Val 
        275                 280                 285             


Gln Ala Ala Phe Pro Gly Ala Phe Ser Phe Arg His Ala Ala Gly Phe 
    290                 295                 300                 


Leu Cys His Cys Pro Pro Gly Phe Glu Gly Ala Asp Cys Gly Val Glu 
305                 310                 315                 320 


Val Asp Glu Cys Ala Ser Arg Pro Cys Leu Asn Gly Gly His Cys Gln 
                325                 330                 335     


Asp Leu Pro Asn Gly Phe Gln Cys His Cys Pro Asp Gly Tyr Ala Gly 
            340                 345                 350         


Pro Thr Cys Glu Glu Asp Val Asp Glu Cys Leu Ser Asp Pro Cys Leu 
        355                 360                 365             


His Gly Gly Thr Cys Ser Asp Thr Val Ala Gly Tyr Ile Cys Arg Cys 
    370                 375                 380                 


Pro Glu Thr Trp Gly Gly Arg Asp Cys Ser Val Gln Leu Thr Gly Cys 
385                 390                 395                 400 


Gln Gly His Thr Cys Pro Leu Ala Ala Thr Cys Ile Pro Ile Phe Glu 
                405                 410                 415     


Ser Gly Val His Ser Tyr Val Cys His Cys Pro Pro Gly Thr His Gly 
            420                 425                 430         


Pro Phe Cys Gly Gln Asn Thr Thr Phe Ser Val Met Ala Gly Ser Pro 
        435                 440                 445             


Ile Gln Ala Ser Val Pro Ala Gly Gly Pro Leu Gly Leu Ala Leu Arg 
    450                 455                 460                 


Phe Arg Thr Thr Leu Pro Ala Gly Thr Leu Ala Thr Arg Asn Asp Thr 
465                 470                 475                 480 


Lys Glu Ser Leu Glu Leu Ala Leu Val Ala Ala Thr Leu Gln Ala Thr 
                485                 490                 495     


Leu Trp Ser Tyr Ser Thr Thr Val Leu Val Leu Arg Leu Pro Asp Leu 
            500                 505                 510         


Ala Leu Asn Asp Gly His Trp His Gln Val Glu Val Val Leu His Leu 
        515                 520                 525             


Ala Thr Leu Glu Leu Arg Leu Trp His Glu Gly Cys Pro Ala Arg Leu 
    530                 535                 540                 


Cys Val Ala Ser Gly Pro Val Ala Leu Ala Ser Thr Ala Ser Ala Thr 
545                 550                 555                 560 


Pro Leu Pro Ala Gly Ile Ser Ser Ala Gln Leu Gly Asp Ala Thr Phe 
                565                 570                 575     


Ala Gly Cys Leu Gln Asp Val Arg Val Asp Gly His Leu Leu Leu Pro 
            580                 585                 590         


Glu Asp Leu Gly Glu Asn Val Leu Leu Gly Cys Glu Arg Arg Glu Gln 
        595                 600                 605             


Cys Arg Pro Leu Pro Cys Val His Gly Gly Ser Cys Val Asp Leu Trp 
    610                 615                 620                 


Thr His Phe Arg Cys Asp Cys Ala Arg Pro His Arg Gly Pro Thr Cys 
625                 630                 635                 640 


Ala Asp Glu Ile Pro Ala Ala Thr Phe Gly Leu Gly Gly Ala Pro Ser 
                645                 650                 655     


Ser Ala Ser Phe Leu Leu Gln Glu Leu Pro Gly Pro Asn Leu Thr Val 
            660                 665                 670         


Ser Phe Leu Leu Arg Thr Arg Glu Ser Ala Gly Leu Leu Leu Gln Phe 
        675                 680                 685             


Ala Asn Asp Ser Ala Ala Gly Leu Thr Val Phe Leu Ser Glu Gly Arg 
    690                 695                 700                 


Ile Arg Ala Glu Val Pro Gly Ser Pro Ala Val Val Leu Pro Gly Arg 
705                 710                 715                 720 


Trp Asp Asp Gly Leu Arg His Leu Val Met Leu Ser Phe Gly Pro Asp 
                725                 730                 735     


Gln Leu Gln Asp Leu Gly Gln His Val His Val Gly Gly Arg Leu Leu 
            740                 745                 750         


Ala Ala Asp Ser Gln Pro Trp Gly Gly Pro Phe Arg Gly Cys Leu Gln 
        755                 760                 765             


Asp Leu Arg Leu Asp Gly Cys His Leu Pro Phe Phe Pro Leu Pro Leu 
    770                 775                 780                 


Asp Asn Ser Ser Gln Pro Ser Glu Leu Gly Gly Arg Gln Ser Trp Asn 
785                 790                 795                 800 


Leu Thr Ala Gly Cys Val Ser Glu Asp Met Cys Ser Pro Asp Pro Cys 
                805                 810                 815     


Phe Asn Gly Gly Thr Cys Leu Val Thr Trp Asn Asp Phe His Cys Thr 
            820                 825                 830         


Cys Pro Ala Asn Phe Thr Gly Pro Thr Cys Ala Gln Gln Leu Trp Cys 
        835                 840                 845             


Pro Gly Gln Pro Cys Leu Pro Pro Ala Thr Cys Glu Glu Val Pro Asp 
    850                 855                 860                 


Gly Phe Val Cys Val Ala Glu Ala Thr Phe Arg Glu Gly Pro Pro Ala 
865                 870                 875                 880 


Ala Phe Ser Gly His Asn Ala Ser Ser Gly Arg Leu Leu Gly Gly Leu 
                885                 890                 895     


Ser Leu Ala Phe Arg Thr Arg Asp Ser Glu Ala Trp Leu Leu Arg Ala 
            900                 905                 910         


Ala Ala Gly Ala Leu Glu Gly Val Trp Leu Ala Val Arg Asn Gly Ser 
        915                 920                 925             


Leu Ala Gly Gly Val Arg Gly Gly His Gly Leu Pro Gly Ala Val Leu 
    930                 935                 940                 


Pro Ile Pro Gly Pro Arg Val Ala Asp Gly Ala Trp His Arg Val Arg 
945                 950                 955                 960 


Leu Ala Met Glu Arg Pro Ala Ala Thr Thr Ser Arg Trp Leu Leu Trp 
                965                 970                 975     


Leu Asp Gly Ala Ala Thr Pro Val Ala Leu Arg Gly Leu Ala Ser Asp 
            980                 985                 990         


Leu Gly Phe Leu Gln Gly Pro Gly  Ala Val Arg Ile Leu  Leu Ala Glu 
        995                 1000                 1005             


Asn Phe  Thr Gly Cys Leu Gly  Arg Val Ala Leu Gly  Gly Leu Pro 
    1010                 1015                 1020             


Leu Pro  Leu Ala Arg Pro Arg  Pro Gly Ala Ala Pro  Gly Ala Arg 
    1025                 1030                 1035             


Glu His  Phe Ala Ser Trp Pro  Gly Thr Pro Ala Pro  Ile Leu Gly 
    1040                 1045                 1050             


Cys Arg  Gly Ala Pro Val Cys  Ala Pro Ser Pro Cys  Leu His Asp 
    1055                 1060                 1065             


Gly Ala  Cys Arg Asp Leu Phe  Asp Ala Phe Ala Cys  Ala Cys Gly 
    1070                 1075                 1080             


Pro Gly  Trp Glu Gly Pro Arg  Cys Glu Ala His Val  Asp Pro Cys 
    1085                 1090                 1095             


His Ser  Ala Pro Cys Ala Arg  Gly Arg Cys His Thr  His Pro Asp 
    1100                 1105                 1110             


Gly Arg  Phe Glu Cys Arg Cys  Pro Pro Gly Phe Gly  Gly Pro Arg 
    1115                 1120                 1125             


Cys Arg  Trp Asp Gly Trp Ala  Gly Gly Trp Ala Ala  Asn Ala Pro 
    1130                 1135                 1140             


Trp Gly  Tyr Gly Gly Ala Glu  Lys Ser Ala Arg Ser  Val Asp Glu 
    1145                 1150                 1155             


Ser Leu  Pro Phe Pro Gly Pro  His Val Leu Ile Cys  Asp Met Arg 
    1160                 1165                 1170             


Arg Thr  Val 
    1175     


<210>  3486
<211>  1285
<212>  PRT
<213>  Homo Sapiens

<400>  3486

Met Ala Leu Ala Arg Pro Gly Thr Pro Asp Pro Gln Ala Leu Ala Ser 
1               5                   10                  15      


Val Leu Leu Leu Leu Leu Trp Ala Pro Ala Leu Ser Leu Leu Ala Gly 
            20                  25                  30          


Thr Val Pro Ser Glu Pro Pro Ser Ala Cys Ala Ser Asp Pro Cys Ala 
        35                  40                  45              


Pro Gly Thr Glu Cys Gln Ala Thr Glu Ser Gly Gly Tyr Thr Cys Gly 
    50                  55                  60                  


Pro Met Glu Pro Arg Gly Cys Ala Thr Gln Pro Cys His His Gly Ala 
65                  70                  75                  80  


Leu Cys Val Pro Gln Gly Pro Asp Pro Thr Gly Phe Arg Cys Tyr Cys 
                85                  90                  95      


Val Pro Gly Phe Gln Gly Pro Arg Cys Glu Leu Asp Ile Asp Glu Cys 
            100                 105                 110         


Ala Ser Arg Pro Cys His His Gly Ala Thr Cys Arg Asn Leu Ala Asp 
        115                 120                 125             


Arg Tyr Glu Cys His Cys Pro Leu Gly Tyr Ala Gly Val Thr Cys Glu 
    130                 135                 140                 


Met Glu Val Asp Glu Cys Ala Ser Ala Pro Cys Leu His Gly Gly Ser 
145                 150                 155                 160 


Cys Leu Asp Gly Val Gly Ser Phe Arg Cys Val Cys Ala Pro Gly Tyr 
                165                 170                 175     


Gly Gly Thr Arg Cys Gln Leu Asp Leu Asp Glu Cys Gln Ser Gln Pro 
            180                 185                 190         


Cys Ala His Gly Gly Thr Cys His Asp Leu Val Asn Gly Phe Arg Cys 
        195                 200                 205             


Asp Cys Ala Gly Thr Gly Tyr Glu Gly Thr His Cys Glu Arg Glu Val 
    210                 215                 220                 


Leu Glu Cys Ala Ser Ala Pro Cys Glu His Asn Ala Ser Cys Leu Glu 
225                 230                 235                 240 


Gly Leu Gly Ser Phe Arg Cys Leu Cys Trp Pro Gly Tyr Ser Gly Glu 
                245                 250                 255     


Leu Cys Glu Val Asp Glu Asp Glu Cys Ala Ser Ser Pro Cys Gln His 
            260                 265                 270         


Gly Gly Arg Cys Leu Gln Arg Ser Asp Pro Ala Leu Tyr Gly Gly Val 
        275                 280                 285             


Gln Ala Ala Phe Pro Gly Ala Phe Ser Phe Arg His Ala Ala Gly Phe 
    290                 295                 300                 


Leu Cys His Cys Pro Pro Gly Phe Glu Gly Ala Asp Cys Gly Val Glu 
305                 310                 315                 320 


Val Asp Glu Cys Ala Ser Arg Pro Cys Leu Asn Gly Gly His Cys Gln 
                325                 330                 335     


Asp Leu Pro Asn Gly Phe Gln Cys His Cys Pro Asp Gly Tyr Ala Gly 
            340                 345                 350         


Pro Thr Cys Glu Glu Asp Val Asp Glu Cys Leu Ser Asp Pro Cys Leu 
        355                 360                 365             


His Gly Gly Thr Cys Ser Asp Thr Val Ala Gly Tyr Ile Cys Arg Cys 
    370                 375                 380                 


Pro Glu Thr Trp Gly Gly Arg Asp Cys Ser Val Gln Leu Thr Gly Cys 
385                 390                 395                 400 


Gln Gly His Thr Cys Pro Leu Ala Ala Thr Cys Ile Pro Ile Phe Glu 
                405                 410                 415     


Ser Gly Val His Ser Tyr Val Cys His Cys Pro Pro Gly Thr His Gly 
            420                 425                 430         


Pro Phe Cys Gly Gln Asn Thr Thr Phe Ser Val Met Ala Gly Ser Pro 
        435                 440                 445             


Ile Gln Ala Ser Val Pro Ala Gly Gly Pro Leu Gly Leu Ala Leu Arg 
    450                 455                 460                 


Phe Arg Thr Thr Leu Pro Ala Gly Thr Leu Ala Thr Arg Asn Asp Thr 
465                 470                 475                 480 


Lys Glu Ser Leu Glu Leu Ala Leu Val Ala Ala Thr Leu Gln Ala Thr 
                485                 490                 495     


Leu Trp Ser Tyr Ser Thr Thr Val Leu Val Leu Arg Leu Pro Asp Leu 
            500                 505                 510         


Ala Leu Asn Asp Gly His Trp His Gln Val Glu Val Val Leu His Leu 
        515                 520                 525             


Ala Thr Leu Glu Leu Arg Leu Trp His Glu Gly Cys Pro Ala Arg Leu 
    530                 535                 540                 


Cys Val Ala Ser Gly Pro Val Ala Leu Ala Ser Thr Ala Ser Ala Thr 
545                 550                 555                 560 


Pro Leu Pro Ala Gly Ile Ser Ser Ala Gln Leu Gly Asp Ala Thr Phe 
                565                 570                 575     


Ala Gly Cys Leu Gln Asp Val Arg Val Asp Gly His Leu Leu Leu Pro 
            580                 585                 590         


Glu Asp Leu Gly Glu Asn Val Leu Leu Gly Cys Glu Arg Arg Glu Gln 
        595                 600                 605             


Cys Arg Pro Leu Pro Cys Val His Gly Gly Ser Cys Val Asp Leu Trp 
    610                 615                 620                 


Thr His Phe Arg Cys Asp Cys Ala Arg Pro His Arg Gly Pro Thr Cys 
625                 630                 635                 640 


Ala Asp Glu Ile Pro Ala Ala Thr Phe Gly Leu Gly Gly Ala Pro Ser 
                645                 650                 655     


Ser Ala Ser Phe Leu Leu Gln Glu Leu Pro Gly Pro Asn Leu Thr Val 
            660                 665                 670         


Ser Phe Leu Leu Arg Thr Arg Glu Ser Ala Gly Leu Leu Leu Gln Phe 
        675                 680                 685             


Ala Asn Asp Ser Ala Ala Gly Leu Thr Val Phe Leu Ser Glu Gly Arg 
    690                 695                 700                 


Ile Arg Ala Glu Val Pro Gly Ser Pro Ala Val Val Leu Pro Gly Arg 
705                 710                 715                 720 


Trp Asp Asp Gly Leu Arg His Leu Val Met Leu Ser Phe Gly Pro Asp 
                725                 730                 735     


Gln Leu Gln Asp Leu Gly Gln His Val His Val Gly Gly Arg Leu Leu 
            740                 745                 750         


Ala Ala Asp Ser Gln Pro Trp Gly Gly Pro Phe Arg Gly Cys Leu Gln 
        755                 760                 765             


Asp Leu Arg Leu Asp Gly Cys His Leu Pro Phe Phe Pro Leu Pro Leu 
    770                 775                 780                 


Asp Asn Ser Ser Gln Pro Ser Glu Leu Gly Gly Arg Gln Ser Trp Asn 
785                 790                 795                 800 


Leu Thr Ala Gly Cys Val Ser Glu Asp Met Cys Ser Pro Asp Pro Cys 
                805                 810                 815     


Phe Asn Gly Gly Thr Cys Leu Val Thr Trp Asn Asp Phe His Cys Thr 
            820                 825                 830         


Cys Pro Ala Asn Phe Thr Gly Pro Thr Cys Ala Gln Gln Leu Trp Cys 
        835                 840                 845             


Pro Gly Gln Pro Cys Leu Pro Pro Ala Thr Cys Glu Glu Val Pro Asp 
    850                 855                 860                 


Gly Phe Val Cys Val Ala Glu Ala Thr Phe Arg Glu Gly Pro Pro Ala 
865                 870                 875                 880 


Ala Phe Ser Gly His Asn Ala Ser Ser Gly Arg Leu Leu Gly Gly Leu 
                885                 890                 895     


Ser Leu Ala Phe Arg Thr Arg Asp Ser Glu Ala Trp Leu Leu Arg Ala 
            900                 905                 910         


Ala Ala Gly Ala Leu Glu Gly Val Trp Leu Ala Val Arg Asn Gly Ser 
        915                 920                 925             


Leu Ala Gly Gly Val Arg Gly Gly His Gly Leu Pro Gly Ala Val Leu 
    930                 935                 940                 


Pro Ile Pro Gly Pro Arg Val Ala Asp Gly Ala Trp His Arg Val Arg 
945                 950                 955                 960 


Leu Ala Met Glu Arg Pro Ala Ala Thr Thr Ser Arg Trp Leu Leu Trp 
                965                 970                 975     


Leu Asp Gly Ala Ala Thr Pro Val Ala Leu Arg Gly Leu Ala Ser Asp 
            980                 985                 990         


Leu Gly Phe Leu Gln Gly Pro Gly  Ala Val Arg Ile Leu  Leu Ala Glu 
        995                 1000                 1005             


Asn Phe  Thr Gly Cys Leu Gly  Arg Val Ala Leu Gly  Gly Leu Pro 
    1010                 1015                 1020             


Leu Pro  Leu Ala Arg Pro Arg  Pro Gly Ala Ala Pro  Gly Ala Arg 
    1025                 1030                 1035             


Glu His  Phe Ala Ser Trp Pro  Gly Thr Pro Ala Pro  Ile Leu Gly 
    1040                 1045                 1050             


Cys Arg  Gly Ala Pro Val Cys  Ala Pro Ser Pro Cys  Leu His Asp 
    1055                 1060                 1065             


Gly Ala  Cys Arg Asp Leu Phe  Asp Ala Phe Ala Cys  Ala Cys Gly 
    1070                 1075                 1080             


Pro Gly  Trp Glu Gly Pro Arg  Cys Glu Ala His Val  Asp Pro Cys 
    1085                 1090                 1095             


His Ser  Ala Pro Cys Ala Arg  Gly Arg Cys His Thr  His Pro Asp 
    1100                 1105                 1110             


Gly Arg  Phe Glu Cys Arg Cys  Pro Pro Gly Phe Gly  Gly Pro Arg 
    1115                 1120                 1125             


Cys Arg  Leu Pro Val Pro Ser  Lys Glu Cys Ser Leu  Asn Val Thr 
    1130                 1135                 1140             


Cys Leu  Asp Gly Ser Pro Cys  Glu Gly Gly Ser Pro  Ala Ala Asn 
    1145                 1150                 1155             


Cys Ser  Cys Leu Glu Gly Leu  Ala Gly Gln Arg Cys  Gln Val Pro 
    1160                 1165                 1170             


Thr Leu  Pro Cys Glu Ala Asn  Pro Cys Leu Asn Gly  Gly Thr Cys 
    1175                 1180                 1185             


Arg Ala  Ala Gly Gly Val Ser  Glu Cys Ile Cys Asn  Ala Arg Phe 
    1190                 1195                 1200             


Ser Gly  Gln Phe Cys Glu Val  Ala Lys Gly Leu Pro  Leu Pro Leu 
    1205                 1210                 1215             


Pro Phe  Pro Leu Leu Glu Val  Ala Val Pro Ala Ala  Cys Ala Cys 
    1220                 1225                 1230             


Leu Leu  Leu Leu Leu Leu Gly  Leu Leu Ser Gly Ile  Leu Ala Ala 
    1235                 1240                 1245             


Arg Lys  Arg Arg Gln Ser Glu  Gly Thr Tyr Ser Pro  Ser Gln Gln 
    1250                 1255                 1260             


Glu Val  Ala Gly Ala Arg Leu  Glu Met Asp Ser Val  Leu Lys Val 
    1265                 1270                 1275             


Pro Pro  Glu Glu Arg Leu Ile  
    1280                 1285 


<210>  3487
<211>  953
<212>  PRT
<213>  Homo Sapiens

<400>  3487

Met Ala Met Glu Pro Gly Ala Leu Trp Thr Phe Leu Gly His Leu Trp 
1               5                   10                  15      


Leu Leu Ala Gly Pro Thr Cys Glu Glu Asp Val Asp Glu Cys Leu Ser 
            20                  25                  30          


Asp Pro Cys Leu His Gly Gly Thr Cys Ser Asp Thr Val Ala Gly Tyr 
        35                  40                  45              


Ile Cys Arg Cys Pro Glu Thr Trp Gly Gly Arg Asp Cys Ser Val Gln 
    50                  55                  60                  


Leu Thr Gly Cys Gln Gly His Thr Cys Pro Leu Ala Ala Thr Cys Ile 
65                  70                  75                  80  


Pro Ile Phe Glu Ser Gly Val His Ser Tyr Val Cys His Cys Pro Pro 
                85                  90                  95      


Gly Thr His Gly Pro Phe Cys Gly Gln Asn Thr Thr Phe Ser Val Met 
            100                 105                 110         


Ala Gly Ser Pro Ile Gln Ala Ser Val Pro Ala Gly Gly Pro Leu Gly 
        115                 120                 125             


Leu Ala Leu Arg Phe Arg Thr Thr Leu Pro Ala Gly Thr Leu Ala Thr 
    130                 135                 140                 


Arg Asn Asp Thr Lys Glu Ser Leu Glu Leu Ala Leu Val Ala Ala Thr 
145                 150                 155                 160 


Leu Gln Ala Thr Leu Trp Ser Tyr Ser Thr Thr Val Leu Val Leu Arg 
                165                 170                 175     


Leu Pro Asp Leu Ala Leu Asn Asp Gly His Trp His Gln Val Glu Val 
            180                 185                 190         


Val Leu His Leu Ala Thr Leu Glu Leu Arg Leu Trp His Glu Gly Cys 
        195                 200                 205             


Pro Ala Arg Leu Cys Val Ala Ser Gly Pro Val Ala Leu Ala Ser Thr 
    210                 215                 220                 


Ala Ser Ala Thr Pro Leu Pro Ala Gly Ile Ser Ser Ala Gln Leu Gly 
225                 230                 235                 240 


Asp Ala Thr Phe Ala Gly Cys Leu Gln Asp Val Arg Val Asp Gly His 
                245                 250                 255     


Leu Leu Leu Pro Glu Asp Leu Gly Glu Asn Val Leu Leu Gly Cys Glu 
            260                 265                 270         


Arg Arg Glu Gln Cys Arg Pro Leu Pro Cys Val His Gly Gly Ser Cys 
        275                 280                 285             


Val Asp Leu Trp Thr His Phe Arg Cys Asp Cys Ala Arg Pro His Arg 
    290                 295                 300                 


Gly Pro Thr Cys Ala Asp Glu Ile Pro Ala Ala Thr Phe Gly Leu Gly 
305                 310                 315                 320 


Gly Ala Pro Ser Ser Ala Ser Phe Leu Leu Gln Glu Leu Pro Gly Pro 
                325                 330                 335     


Asn Leu Thr Val Ser Phe Leu Leu Arg Thr Arg Glu Ser Ala Gly Leu 
            340                 345                 350         


Leu Leu Gln Phe Ala Asn Asp Ser Ala Ala Gly Leu Thr Val Phe Leu 
        355                 360                 365             


Ser Glu Gly Arg Ile Arg Ala Glu Val Pro Gly Ser Pro Ala Val Val 
    370                 375                 380                 


Leu Pro Gly Arg Trp Asp Asp Gly Leu Arg His Leu Val Met Leu Ser 
385                 390                 395                 400 


Phe Gly Pro Asp Gln Leu Gln Asp Leu Gly Gln His Val His Val Gly 
                405                 410                 415     


Gly Arg Leu Leu Ala Ala Asp Ser Gln Pro Trp Gly Gly Pro Phe Arg 
            420                 425                 430         


Gly Cys Leu Gln Asp Leu Arg Leu Asp Gly Cys His Leu Pro Phe Phe 
        435                 440                 445             


Pro Leu Pro Leu Asp Asn Ser Ser Gln Pro Ser Glu Leu Gly Gly Arg 
    450                 455                 460                 


Gln Ser Trp Asn Leu Thr Ala Gly Cys Val Ser Glu Asp Met Cys Ser 
465                 470                 475                 480 


Pro Asp Pro Cys Phe Asn Gly Gly Thr Cys Leu Val Thr Trp Asn Asp 
                485                 490                 495     


Phe His Cys Thr Cys Pro Ala Asn Phe Thr Gly Pro Thr Cys Ala Gln 
            500                 505                 510         


Gln Leu Trp Cys Pro Gly Gln Pro Cys Leu Pro Pro Ala Thr Cys Glu 
        515                 520                 525             


Glu Val Pro Asp Gly Phe Val Cys Val Ala Glu Ala Thr Phe Arg Glu 
    530                 535                 540                 


Gly Pro Pro Ala Ala Phe Ser Gly His Asn Ala Ser Ser Gly Arg Leu 
545                 550                 555                 560 


Leu Gly Gly Leu Ser Leu Ala Phe Arg Thr Arg Asp Ser Glu Ala Trp 
                565                 570                 575     


Leu Leu Arg Ala Ala Ala Gly Ala Leu Glu Gly Val Trp Leu Ala Val 
            580                 585                 590         


Arg Asn Gly Ser Leu Ala Gly Gly Val Arg Gly Gly His Gly Leu Pro 
        595                 600                 605             


Gly Ala Val Leu Pro Ile Pro Gly Pro Arg Val Ala Asp Gly Ala Trp 
    610                 615                 620                 


His Arg Val Arg Leu Ala Met Glu Arg Pro Ala Ala Thr Thr Ser Arg 
625                 630                 635                 640 


Trp Leu Leu Trp Leu Asp Gly Ala Ala Thr Pro Val Ala Leu Arg Gly 
                645                 650                 655     


Leu Ala Ser Asp Leu Gly Phe Leu Gln Gly Pro Gly Ala Val Arg Ile 
            660                 665                 670         


Leu Leu Ala Glu Asn Phe Thr Gly Cys Leu Gly Arg Val Ala Leu Gly 
        675                 680                 685             


Gly Leu Pro Leu Pro Leu Ala Arg Pro Arg Pro Gly Ala Ala Pro Gly 
    690                 695                 700                 


Ala Arg Glu His Phe Ala Ser Trp Pro Gly Thr Pro Ala Pro Ile Leu 
705                 710                 715                 720 


Gly Cys Arg Gly Ala Pro Val Cys Ala Pro Ser Pro Cys Leu His Asp 
                725                 730                 735     


Gly Ala Cys Arg Asp Leu Phe Asp Ala Phe Ala Cys Ala Cys Gly Pro 
            740                 745                 750         


Gly Trp Glu Gly Pro Arg Cys Glu Ala His Val Asp Pro Cys His Ser 
        755                 760                 765             


Ala Pro Cys Ala Arg Gly Arg Cys His Thr His Pro Asp Gly Arg Phe 
    770                 775                 780                 


Glu Cys Arg Cys Pro Pro Gly Phe Gly Gly Pro Arg Cys Arg Leu Pro 
785                 790                 795                 800 


Val Pro Ser Lys Glu Cys Ser Leu Asn Val Thr Cys Leu Asp Gly Ser 
                805                 810                 815     


Pro Cys Glu Gly Gly Ser Pro Ala Ala Asn Cys Ser Cys Leu Glu Gly 
            820                 825                 830         


Leu Ala Gly Gln Arg Cys Gln Val Pro Thr Leu Pro Cys Glu Ala Asn 
        835                 840                 845             


Pro Cys Leu Asn Gly Gly Thr Cys Arg Ala Ala Gly Gly Val Ser Glu 
    850                 855                 860                 


Cys Ile Cys Asn Ala Arg Phe Ser Gly Gln Phe Cys Glu Val Ala Lys 
865                 870                 875                 880 


Gly Leu Pro Leu Pro Leu Pro Phe Pro Leu Leu Glu Val Ala Val Pro 
                885                 890                 895     


Ala Ala Cys Ala Cys Leu Leu Leu Leu Leu Leu Gly Leu Leu Ser Gly 
            900                 905                 910         


Ile Leu Ala Ala Arg Lys Arg Arg Gln Ser Glu Gly Thr Tyr Ser Pro 
        915                 920                 925             


Ser Gln Gln Glu Val Ala Gly Ala Arg Leu Glu Met Asp Ser Val Leu 
    930                 935                 940                 


Lys Val Pro Pro Glu Glu Arg Leu Ile 
945                 950             


<210>  3488
<211>  220
<212>  PRT
<213>  Homo Sapiens

<400>  3488

Met Ala Gly Leu Ser Arg Gly Ser Ala Arg Ala Leu Leu Ala Ala Leu 
1               5                   10                  15      


Leu Ala Ser Thr Leu Leu Ala Leu Leu Val Ser Pro Ala Arg Gly Arg 
            20                  25                  30          


Gly Gly Arg Asp His Gly Asp Trp Asp Glu Ala Ser Arg Leu Pro Pro 
        35                  40                  45              


Leu Pro Pro Arg Glu Asp Ala Ala Arg Val Ala Arg Phe Val Thr His 
    50                  55                  60                  


Val Ser Asp Trp Gly Ala Leu Ala Thr Ile Ser Thr Leu Glu Ala Val 
65                  70                  75                  80  


Arg Gly Arg Pro Phe Ala Asp Val Leu Ser Leu Ser Asp Gly Pro Pro 
                85                  90                  95      


Gly Ala Gly Ser Gly Val Pro Tyr Phe Tyr Leu Ser Pro Leu Gln Leu 
            100                 105                 110         


Ser Val Ser Asn Leu Gln Glu Asn Pro Tyr Ala Thr Leu Thr Met Thr 
        115                 120                 125             


Leu Ala Gln Thr Asn Phe Cys Lys Lys His Gly Phe Asp Pro Gln Ser 
    130                 135                 140                 


Pro Leu Cys Val His Ile Met Leu Ser Gly Thr Val Thr Lys Val Asn 
145                 150                 155                 160 


Glu Thr Glu Met Asp Ile Ala Lys His Ser Leu Phe Ile Arg His Pro 
                165                 170                 175     


Glu Met Lys Thr Trp Pro Ser Ser His Asn Trp Phe Phe Ala Lys Leu 
            180                 185                 190         


Asn Ile Thr Asn Ile Trp Val Leu Asp Tyr Phe Gly Gly Pro Lys Ile 
        195                 200                 205             


Val Thr Pro Glu Glu Tyr Tyr Asn Val Thr Val Gln 
    210                 215                 220 


<210>  3489
<211>  290
<212>  PRT
<213>  Homo Sapiens

<400>  3489

Met Ser Val Arg Arg Gly Arg Arg Pro Ala Arg Pro Gly Thr Arg Leu 
1               5                   10                  15      


Ser Trp Leu Leu Cys Cys Ser Ala Leu Leu Ser Pro Ala Ala Gly Tyr 
            20                  25                  30          


Val Ile Val Ser Ser Val Ser Trp Ala Val Thr Asn Glu Val Asp Glu 
        35                  40                  45              


Glu Leu Asp Ser Ala Ser Thr Glu Glu Ala Met Pro Ala Leu Leu Glu 
    50                  55                  60                  


Asp Ser Gly Ser Ile Trp Gln Gln Ser Phe Pro Ala Ser Ala His Lys 
65                  70                  75                  80  


Glu Asp Ala His Leu Arg Pro Arg Ala Gly Ala Ala Arg Ala Arg Pro 
                85                  90                  95      


Pro Pro Ala Pro Pro Gly Met Phe Ser Tyr Arg Arg Glu Gly Gly Gln 
            100                 105                 110         


Thr Ala Ser Ala Pro Pro Gly Pro Arg Leu Arg Ala Ala Thr Ala Arg 
        115                 120                 125             


Ser Leu Ala His Ala Ser Val Trp Gly Cys Leu Ala Thr Val Ser Thr 
    130                 135                 140                 


His Lys Lys Ile Gln Gly Leu Pro Phe Gly Asn Cys Leu Pro Val Ser 
145                 150                 155                 160 


Asp Gly Pro Phe Asn Asn Ser Thr Gly Ile Pro Phe Phe Tyr Met Thr 
                165                 170                 175     


Ala Lys Asp Pro Val Val Ala Asp Leu Met Lys Asn Pro Met Ala Ser 
            180                 185                 190         


Leu Met Leu Pro Glu Ser Glu Gly Glu Phe Cys Arg Lys Asn Ile Val 
        195                 200                 205             


Asp Pro Glu Asp Pro Arg Cys Val Gln Leu Thr Leu Thr Gly Gln Met 
    210                 215                 220                 


Ile Ala Val Ser Pro Glu Glu Val Glu Phe Ala Lys Gln Ala Met Phe 
225                 230                 235                 240 


Ser Arg His Pro Gly Met Arg Lys Trp Pro Arg Gln Tyr Glu Trp Phe 
                245                 250                 255     


Phe Met Lys Met Arg Ile Glu His Ile Trp Leu Gln Lys Trp Tyr Gly 
            260                 265                 270         


Gly Ala Ser Ser Ile Ser Arg Glu Glu Tyr Phe Lys Ala Val Pro Arg 
        275                 280                 285             


Lys Ala 
    290 


<210>  3490
<211>  422
<212>  PRT
<213>  Homo Sapiens

<400>  3490

Met Ala Pro Trp Pro Pro Lys Gly Leu Val Pro Ala Met Leu Trp Gly 
1               5                   10                  15      


Leu Ser Leu Phe Leu Asn Leu Pro Gly Pro Ile Trp Leu Gln Pro Ser 
            20                  25                  30          


Pro Pro Pro Gln Ser Ser Pro Pro Pro Gln Pro His Pro Cys His Thr 
        35                  40                  45              


Cys Arg Gly Leu Val Asp Ser Phe Asn Lys Gly Leu Glu Arg Thr Ile 
    50                  55                  60                  


Arg Asp Asn Phe Gly Gly Gly Asn Thr Ala Trp Glu Glu Glu Asn Leu 
65                  70                  75                  80  


Ser Lys Tyr Lys Asp Ser Glu Thr Arg Leu Val Glu Val Leu Glu Gly 
                85                  90                  95      


Val Cys Ser Lys Ser Asp Phe Glu Cys His Arg Leu Leu Glu Leu Ser 
            100                 105                 110         


Glu Glu Leu Val Glu Ser Trp Trp Phe His Lys Gln Gln Glu Ala Pro 
        115                 120                 125             


Asp Leu Phe Gln Trp Leu Cys Ser Asp Ser Leu Lys Leu Cys Cys Pro 
    130                 135                 140                 


Ala Gly Thr Phe Gly Pro Ser Cys Leu Pro Cys Pro Gly Gly Thr Glu 
145                 150                 155                 160 


Arg Pro Cys Gly Gly Tyr Gly Gln Cys Glu Gly Glu Gly Thr Arg Gly 
                165                 170                 175     


Gly Ser Gly His Cys Asp Cys Gln Ala Gly Tyr Gly Gly Glu Ala Cys 
            180                 185                 190         


Gly Gln Cys Gly Leu Gly Tyr Phe Glu Ala Glu Arg Asn Ala Ser His 
        195                 200                 205             


Leu Val Cys Ser Ala Cys Phe Gly Pro Cys Ala Arg Cys Ser Gly Pro 
    210                 215                 220                 


Glu Glu Ser Asn Cys Leu Gln Cys Lys Lys Gly Trp Ala Leu His His 
225                 230                 235                 240 


Leu Lys Cys Val Asp Ile Asp Glu Cys Gly Thr Glu Gly Ala Asn Cys 
                245                 250                 255     


Gly Ala Asp Gln Phe Cys Val Asn Thr Glu Gly Ser Tyr Glu Cys Arg 
            260                 265                 270         


Asp Cys Ala Lys Ala Cys Leu Gly Cys Met Gly Ala Gly Pro Gly Arg 
        275                 280                 285             


Cys Lys Lys Cys Ser Pro Gly Tyr Gln Gln Val Gly Ser Lys Cys Leu 
    290                 295                 300                 


Asp Val Asp Glu Cys Glu Thr Glu Val Cys Pro Gly Glu Asn Lys Gln 
305                 310                 315                 320 


Cys Glu Asn Thr Glu Gly Gly Tyr Arg Cys Ile Cys Ala Glu Gly Tyr 
                325                 330                 335     


Lys Gln Met Glu Gly Ile Cys Val Lys Glu Gln Ile Pro Gly Ala Phe 
            340                 345                 350         


Pro Ile Leu Thr Asp Leu Thr Pro Glu Thr Thr Arg Arg Trp Lys Leu 
        355                 360                 365             


Gly Ser His Pro His Ser Thr Tyr Val Lys Met Lys Met Gln Arg Asp 
    370                 375                 380                 


Glu Ala Thr Phe Pro Gly Leu Tyr Gly Lys Gln Val Ala Lys Leu Gly 
385                 390                 395                 400 


Ser Gln Ser Arg Gln Ser Asp Arg Gly Thr Arg Leu Ile His Ser Gln 
                405                 410                 415     


Gln Ala Ser Ser Gln Arg 
            420         


<210>  3491
<211>  420
<212>  PRT
<213>  Homo Sapiens

<400>  3491

Met Ala Pro Trp Pro Pro Lys Gly Leu Val Pro Ala Met Leu Trp Gly 
1               5                   10                  15      


Leu Ser Leu Phe Leu Asn Leu Pro Gly Pro Ile Trp Leu Gln Pro Ser 
            20                  25                  30          


Pro Pro Pro Gln Ser Ser Pro Pro Pro Gln Pro His Pro Cys His Thr 
        35                  40                  45              


Cys Arg Gly Leu Val Asp Ser Phe Asn Lys Gly Leu Glu Arg Thr Ile 
    50                  55                  60                  


Arg Asp Asn Phe Gly Gly Gly Asn Thr Ala Trp Glu Glu Glu Asn Leu 
65                  70                  75                  80  


Ser Lys Tyr Lys Asp Ser Glu Thr Arg Leu Val Glu Val Leu Glu Gly 
                85                  90                  95      


Val Cys Ser Lys Ser Asp Phe Glu Cys His Arg Leu Leu Glu Leu Ser 
            100                 105                 110         


Glu Glu Leu Val Glu Ser Trp Trp Phe His Lys Gln Gln Glu Ala Pro 
        115                 120                 125             


Asp Leu Phe Gln Trp Leu Cys Ser Asp Ser Leu Lys Leu Cys Cys Pro 
    130                 135                 140                 


Ala Gly Thr Phe Gly Pro Ser Cys Leu Pro Cys Pro Gly Gly Thr Glu 
145                 150                 155                 160 


Arg Pro Cys Gly Gly Tyr Gly Gln Cys Glu Gly Glu Gly Thr Arg Gly 
                165                 170                 175     


Gly Ser Gly His Cys Asp Cys Gln Ala Gly Tyr Gly Gly Glu Ala Cys 
            180                 185                 190         


Gly Gln Cys Gly Leu Gly Tyr Phe Glu Ala Glu Arg Asn Ala Ser His 
        195                 200                 205             


Leu Val Cys Ser Ala Cys Phe Gly Pro Cys Ala Arg Cys Ser Gly Pro 
    210                 215                 220                 


Glu Glu Ser Asn Cys Leu Gln Cys Lys Lys Gly Trp Ala Leu His His 
225                 230                 235                 240 


Leu Lys Cys Val Asp Ile Asp Glu Cys Gly Thr Glu Gly Ala Asn Cys 
                245                 250                 255     


Gly Ala Asp Gln Phe Cys Val Asn Thr Glu Gly Ser Tyr Glu Cys Arg 
            260                 265                 270         


Asp Cys Ala Lys Ala Cys Leu Gly Cys Met Gly Ala Gly Pro Gly Arg 
        275                 280                 285             


Cys Lys Lys Cys Ser Pro Gly Tyr Gln Gln Val Gly Ser Lys Cys Leu 
    290                 295                 300                 


Asp Val Asp Glu Cys Glu Thr Glu Val Cys Pro Gly Glu Asn Lys Gln 
305                 310                 315                 320 


Cys Glu Asn Thr Glu Gly Gly Tyr Arg Cys Ile Cys Ala Glu Gly Tyr 
                325                 330                 335     


Lys Gln Met Glu Gly Ile Cys Val Lys Glu Gln Ile Pro Glu Ser Ala 
            340                 345                 350         


Gly Phe Phe Ser Glu Met Thr Glu Asp Glu Leu Val Val Leu Gln Gln 
        355                 360                 365             


Met Phe Phe Gly Ile Ile Ile Cys Ala Leu Ala Thr Leu Ala Ala Lys 
    370                 375                 380                 


Gly Asp Leu Val Phe Thr Ala Ile Phe Ile Gly Ala Val Ala Ala Met 
385                 390                 395                 400 


Thr Gly Tyr Trp Leu Ser Glu Arg Ser Asp Arg Val Leu Glu Gly Phe 
                405                 410                 415     


Ile Lys Gly Arg 
            420 


<210>  3492
<211>  420
<212>  PRT
<213>  Homo Sapiens

<400>  3492

Met Ala Pro Trp Pro Pro Lys Gly Leu Val Pro Ala Met Leu Trp Gly 
1               5                   10                  15      


Leu Ser Leu Phe Leu Asn Leu Pro Gly Pro Ile Trp Leu Gln Pro Ser 
            20                  25                  30          


Pro Pro Pro Gln Ser Ser Pro Pro Pro Gln Pro His Pro Cys His Thr 
        35                  40                  45              


Cys Arg Gly Leu Val Asp Ser Phe Asn Lys Gly Leu Glu Arg Thr Ile 
    50                  55                  60                  


Arg Asp Asn Phe Gly Gly Gly Asn Thr Ala Trp Glu Glu Glu Asn Leu 
65                  70                  75                  80  


Ser Lys Tyr Lys Asp Ser Glu Thr Arg Leu Val Glu Val Leu Glu Gly 
                85                  90                  95      


Val Cys Ser Lys Ser Asp Phe Glu Cys His Arg Leu Leu Glu Leu Ser 
            100                 105                 110         


Glu Glu Leu Val Glu Ser Trp Trp Phe His Lys Gln Gln Glu Ala Pro 
        115                 120                 125             


Asp Leu Phe Gln Trp Leu Cys Ser Asp Ser Leu Lys Leu Cys Cys Pro 
    130                 135                 140                 


Ala Gly Thr Phe Gly Pro Ser Cys Leu Pro Cys Pro Gly Gly Thr Glu 
145                 150                 155                 160 


Arg Pro Cys Gly Gly Tyr Gly Gln Cys Glu Gly Glu Gly Thr Arg Gly 
                165                 170                 175     


Gly Ser Gly His Cys Asp Cys Gln Ala Gly Tyr Gly Gly Glu Ala Cys 
            180                 185                 190         


Gly Gln Cys Gly Leu Gly Tyr Phe Glu Ala Glu Arg Asn Ala Ser His 
        195                 200                 205             


Leu Val Cys Ser Ala Cys Phe Gly Pro Cys Ala Arg Cys Ser Gly Pro 
    210                 215                 220                 


Glu Glu Ser Asn Cys Leu Gln Cys Lys Lys Gly Trp Ala Leu His His 
225                 230                 235                 240 


Leu Lys Cys Val Asp Ile Asp Glu Cys Gly Thr Glu Gly Ala Asn Cys 
                245                 250                 255     


Gly Ala Asp Gln Phe Cys Val Asn Thr Glu Gly Ser Tyr Glu Cys Arg 
            260                 265                 270         


Asp Cys Ala Lys Ala Cys Leu Gly Cys Met Gly Ala Gly Pro Gly Arg 
        275                 280                 285             


Cys Lys Lys Cys Ser Pro Gly Tyr Gln Gln Val Gly Ser Lys Cys Leu 
    290                 295                 300                 


Asp Val Asp Glu Cys Glu Thr Glu Val Cys Pro Gly Glu Asn Lys Gln 
305                 310                 315                 320 


Cys Glu Asn Thr Glu Gly Gly Tyr Arg Cys Ile Cys Ala Glu Gly Tyr 
                325                 330                 335     


Lys Gln Met Glu Gly Ile Cys Val Lys Glu Gln Ile Pro Glu Ser Ala 
            340                 345                 350         


Gly Phe Phe Ser Glu Met Thr Glu Asp Glu Leu Val Val Leu Gln Gln 
        355                 360                 365             


Met Phe Phe Gly Ile Ile Ile Cys Ala Leu Ala Thr Leu Ala Ala Lys 
    370                 375                 380                 


Gly Asp Leu Val Phe Thr Ala Ile Phe Ile Gly Ala Val Ala Ala Met 
385                 390                 395                 400 


Thr Gly Tyr Trp Leu Ser Glu Arg Ser Asp Arg Val Leu Glu Gly Phe 
                405                 410                 415     


Ile Lys Gly Arg 
            420 


<210>  3493
<211>  420
<212>  PRT
<213>  Homo Sapiens

<400>  3493

Met Ala Pro Trp Pro Pro Lys Gly Leu Val Pro Ala Met Leu Trp Gly 
1               5                   10                  15      


Leu Ser Leu Phe Leu Asn Leu Pro Gly Pro Ile Trp Leu Gln Pro Ser 
            20                  25                  30          


Pro Pro Pro Gln Ser Ser Pro Pro Pro Gln Pro His Pro Cys His Thr 
        35                  40                  45              


Cys Arg Gly Leu Val Asp Ser Phe Asn Lys Gly Leu Glu Arg Thr Ile 
    50                  55                  60                  


Arg Asp Asn Phe Gly Gly Gly Asn Thr Ala Trp Glu Glu Glu Asn Leu 
65                  70                  75                  80  


Ser Lys Tyr Lys Asp Ser Glu Thr Arg Leu Val Glu Val Leu Glu Gly 
                85                  90                  95      


Val Cys Ser Lys Ser Asp Phe Glu Cys His Arg Leu Leu Glu Leu Ser 
            100                 105                 110         


Glu Glu Leu Val Glu Ser Trp Trp Phe His Lys Gln Gln Glu Ala Pro 
        115                 120                 125             


Asp Leu Phe Gln Trp Leu Cys Ser Asp Ser Leu Lys Leu Cys Cys Pro 
    130                 135                 140                 


Ala Gly Thr Phe Gly Pro Ser Cys Leu Pro Cys Pro Gly Gly Thr Glu 
145                 150                 155                 160 


Arg Pro Cys Gly Gly Tyr Gly Gln Cys Glu Gly Glu Gly Thr Arg Gly 
                165                 170                 175     


Gly Ser Gly His Cys Asp Cys Gln Ala Gly Tyr Gly Gly Glu Ala Cys 
            180                 185                 190         


Gly Gln Cys Gly Leu Gly Tyr Phe Glu Ala Glu Arg Asn Ala Ser His 
        195                 200                 205             


Leu Val Cys Ser Ala Cys Phe Gly Pro Cys Ala Arg Cys Ser Gly Pro 
    210                 215                 220                 


Glu Glu Ser Asn Cys Leu Gln Cys Lys Lys Gly Trp Ala Leu His His 
225                 230                 235                 240 


Leu Lys Cys Val Asp Ile Asp Glu Cys Gly Thr Glu Gly Ala Asn Cys 
                245                 250                 255     


Gly Ala Asp Gln Phe Cys Val Asn Thr Glu Gly Ser Tyr Glu Cys Arg 
            260                 265                 270         


Asp Cys Ala Lys Ala Cys Leu Gly Cys Met Gly Ala Gly Pro Gly Arg 
        275                 280                 285             


Cys Lys Lys Cys Ser Pro Gly Tyr Gln Gln Val Gly Ser Lys Cys Leu 
    290                 295                 300                 


Asp Val Asp Glu Cys Glu Thr Glu Val Cys Pro Gly Glu Asn Lys Gln 
305                 310                 315                 320 


Cys Glu Asn Thr Glu Gly Gly Tyr Arg Cys Ile Cys Ala Glu Gly Tyr 
                325                 330                 335     


Lys Gln Met Glu Gly Ile Cys Val Lys Glu Gln Ile Pro Glu Ser Ala 
            340                 345                 350         


Gly Phe Phe Ser Glu Met Thr Glu Asp Glu Leu Val Val Leu Gln Gln 
        355                 360                 365             


Met Phe Phe Gly Ile Ile Ile Cys Ala Leu Ala Thr Leu Ala Ala Lys 
    370                 375                 380                 


Gly Asp Leu Val Phe Thr Ala Ile Phe Ile Gly Ala Val Ala Ala Met 
385                 390                 395                 400 


Thr Gly Tyr Trp Leu Ser Glu Arg Ser Asp Arg Val Leu Glu Gly Phe 
                405                 410                 415     


Ile Lys Gly Arg 
            420 


<210>  3494
<211>  101
<212>  PRT
<213>  Homo Sapiens

<400>  3494

Met Ala Pro Trp Pro Pro Lys Gly Leu Val Pro Ala Met Leu Trp Gly 
1               5                   10                  15      


Leu Ser Leu Phe Leu Asn Leu Pro Gly Pro Ile Trp Leu Gln Pro Ser 
            20                  25                  30          


Pro Pro Pro Gln Ser Ser Pro Pro Pro Gln Pro His Pro Cys His Thr 
        35                  40                  45              


Cys Arg Gly Leu Val Asp Ser Phe Asn Lys Gly Leu Glu Arg Thr Ile 
    50                  55                  60                  


Arg Asp Asn Phe Gly Gly Gly Asn Thr Ala Trp Glu Glu Glu Asn Leu 
65                  70                  75                  80  


Ser Lys Tyr Lys Asp Ser Leu Ser Trp Gly Asn Arg Glu Ala Leu Arg 
                85                  90                  95      


Trp Leu Arg Ala Val 
            100     


<210>  3495
<211>  100
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3495

Xaa Pro Ala His Leu Ser Ala Asp Ile Asp Glu Cys Gly Thr Glu Gly 
1               5                   10                  15      


Ala Asn Cys Gly Ala Asp Gln Phe Cys Val Asn Thr Glu Gly Ser Tyr 
            20                  25                  30          


Glu Cys Arg Asp Cys Ala Lys Ala Cys Leu Gly Cys Met Gly Ala Gly 
        35                  40                  45              


Pro Gly Arg Cys Lys Lys Cys Ser Pro Gly Tyr Gln Gln Met Trp Met 
    50                  55                  60                  


Ser Val Arg Gln Arg Cys Val Arg Glu Arg Thr Ser Ser Val Lys Thr 
65                  70                  75                  80  


Pro Arg Ala Val Ile Ala Ala Ser Val Pro Arg Ala Thr Ser Arg Trp 
                85                  90                  95      


Lys Ala Ser Val 
            100 


<210>  3496
<211>  229
<212>  PRT
<213>  Homo Sapiens

<400>  3496

Met Arg Leu Pro Arg Arg Ala Ala Leu Gly Leu Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Leu Pro Pro Ala Pro Glu Ala Ala Lys Lys Pro Thr Pro Cys His 
            20                  25                  30          


Arg Cys Arg Gly Leu Val Asp Lys Phe Asn Gln Gly Met Val Asp Thr 
        35                  40                  45              


Ala Lys Lys Asn Phe Gly Gly Gly Asn Thr Ala Trp Glu Glu Lys Thr 
    50                  55                  60                  


Leu Ser Lys Tyr Glu Ser Ser Glu Ile Arg Leu Leu Glu Ile Leu Glu 
65                  70                  75                  80  


Gly Leu Cys Glu Ser Ser Asp Phe Glu Cys Asn Gln Met Leu Glu Ala 
                85                  90                  95      


Gln Glu Glu His Leu Glu Ala Trp Trp Leu Gln Leu Lys Ser Glu Tyr 
            100                 105                 110         


Pro Asp Leu Phe Glu Trp Phe Cys Val Lys Thr Leu Lys Val Cys Cys 
        115                 120                 125             


Ser Pro Gly Thr Tyr Gly Pro Asp Cys Leu Ala Cys Gln Gly Gly Ser 
    130                 135                 140                 


Gln Arg Pro Cys Ser Gly Asn Gly His Cys Ser Gly Asp Gly Ser Arg 
145                 150                 155                 160 


Gln Gly Asp Gly Ser Cys Arg Cys His Met Gly Tyr Gln Gly Pro Leu 
                165                 170                 175     


Cys Thr Asp Cys Met Asp Gly Tyr Phe Ser Ser Leu Arg Asn Glu Thr 
            180                 185                 190         


His Ser Ile Cys Thr Ala Cys Asp Glu Ser Cys Lys Thr Cys Ser Gly 
        195                 200                 205             


Leu Thr Asn Arg Asp Cys Gly Glu Cys Glu Val Gly Trp Val Leu Asp 
    210                 215                 220                 


Glu Gly Ala Cys Val 
225                 


<210>  3497
<211>  353
<212>  PRT
<213>  Homo Sapiens

<400>  3497

Met Arg Leu Pro Arg Arg Ala Ala Leu Gly Leu Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Leu Pro Pro Ala Pro Glu Ala Ala Lys Lys Pro Thr Pro Cys His 
            20                  25                  30          


Arg Cys Arg Gly Leu Val Asp Lys Phe Asn Gln Gly Met Val Asp Thr 
        35                  40                  45              


Ala Lys Lys Asn Phe Gly Gly Gly Asn Thr Ala Trp Glu Glu Lys Thr 
    50                  55                  60                  


Leu Ser Lys Tyr Glu Ser Ser Glu Ile Arg Leu Leu Glu Ile Leu Glu 
65                  70                  75                  80  


Gly Leu Cys Glu Ser Ser Asp Phe Glu Cys Asn Gln Met Leu Glu Ala 
                85                  90                  95      


Gln Glu Glu His Leu Glu Ala Trp Trp Leu Gln Leu Lys Ser Glu Tyr 
            100                 105                 110         


Pro Asp Leu Phe Glu Trp Phe Cys Val Lys Thr Leu Lys Val Cys Cys 
        115                 120                 125             


Ser Pro Gly Thr Tyr Gly Pro Asp Cys Leu Ala Cys Gln Gly Gly Ser 
    130                 135                 140                 


Gln Arg Pro Cys Ser Gly Asn Gly His Cys Ser Gly Asp Gly Ser Arg 
145                 150                 155                 160 


Gln Gly Asp Gly Ser Cys Arg Cys His Met Gly Tyr Gln Gly Pro Leu 
                165                 170                 175     


Cys Thr Asp Cys Met Asp Gly Tyr Phe Ser Ser Leu Arg Asn Glu Thr 
            180                 185                 190         


His Ser Ile Cys Thr Ala Cys Asp Glu Ser Cys Lys Thr Cys Ser Gly 
        195                 200                 205             


Leu Thr Asn Arg Asp Cys Gly Glu Cys Glu Val Gly Trp Val Leu Asp 
    210                 215                 220                 


Glu Gly Ala Cys Val Asp Val Asp Glu Cys Ala Ala Glu Pro Pro Pro 
225                 230                 235                 240 


Cys Ser Ala Ala Gln Phe Cys Lys Asn Ala Asn Gly Ser Tyr Thr Cys 
                245                 250                 255     


Glu Glu Cys Asp Ser Ser Cys Val Gly Cys Thr Gly Glu Gly Pro Gly 
            260                 265                 270         


Asn Cys Lys Glu Cys Ile Ser Gly Tyr Ala Arg Glu His Gly Gln Cys 
        275                 280                 285             


Ala Asp Val Asp Glu Cys Ser Leu Ala Glu Lys Thr Cys Val Arg Lys 
    290                 295                 300                 


Asn Glu Asn Cys Tyr Asn Thr Pro Gly Ser Tyr Val Cys Val Cys Pro 
305                 310                 315                 320 


Asp Gly Phe Glu Glu Thr Glu Asp Ala Cys Val Pro Pro Ala Glu Ala 
                325                 330                 335     


Glu Ala Thr Glu Gly Glu Ser Pro Thr Gln Leu Pro Ser Arg Glu Asp 
            340                 345                 350         


Leu 
    


<210>  3498
<211>  321
<212>  PRT
<213>  Homo Sapiens

<400>  3498

Met Arg Leu Pro Arg Arg Ala Ala Leu Gly Leu Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Leu Pro Pro Ala Pro Glu Ala Ala Lys Lys Pro Thr Pro Cys His 
            20                  25                  30          


Arg Cys Arg Gly Leu Val Asp Lys Phe Asn Gln Gly Met Val Asp Thr 
        35                  40                  45              


Ala Lys Lys Asn Phe Gly Gly Gly Asn Thr Ala Trp Glu Glu Lys Thr 
    50                  55                  60                  


Leu Ser Lys Tyr Glu Ser Ser Glu Ile Arg Leu Leu Glu Ile Leu Glu 
65                  70                  75                  80  


Gly Leu Cys Glu Ser Ser Asp Phe Glu Cys Asn Gln Met Leu Glu Ala 
                85                  90                  95      


Gln Glu Glu His Leu Glu Ala Trp Trp Leu Gln Leu Lys Ser Glu Tyr 
            100                 105                 110         


Pro Asp Leu Phe Glu Trp Phe Cys Val Lys Thr Leu Lys Val Cys Cys 
        115                 120                 125             


Ser Pro Gly Thr Tyr Gly Pro Asp Cys Leu Ala Cys Gln Gly Gly Ser 
    130                 135                 140                 


Gln Arg Pro Cys Ser Gly Asn Gly His Cys Ser Gly Asp Gly Ser Arg 
145                 150                 155                 160 


Gln Gly Asp Gly Ser Cys Arg Cys His Met Gly Tyr Gln Gly Pro Leu 
                165                 170                 175     


Cys Thr Asp Cys Met Asp Gly Tyr Phe Ser Ser Leu Arg Asn Glu Thr 
            180                 185                 190         


His Ser Ile Cys Thr Ala Cys Asp Glu Ser Cys Lys Thr Cys Ser Gly 
        195                 200                 205             


Leu Thr Asn Arg Asp Cys Gly Glu Cys Glu Val Gly Trp Val Leu Asp 
    210                 215                 220                 


Glu Gly Ala Cys Val Asp Val Asp Glu Cys Ala Ala Glu Pro Pro Pro 
225                 230                 235                 240 


Cys Ser Ala Ala Gln Phe Cys Lys Asn Ala Asn Gly Ser Tyr Thr Cys 
                245                 250                 255     


Glu Asp Val Asp Glu Cys Ser Leu Ala Glu Lys Thr Cys Val Arg Lys 
            260                 265                 270         


Asn Glu Asn Cys Tyr Asn Thr Pro Gly Ser Tyr Val Cys Val Cys Pro 
        275                 280                 285             


Asp Gly Phe Glu Glu Thr Glu Asp Ala Cys Val Pro Pro Ala Glu Ala 
    290                 295                 300                 


Glu Ala Thr Glu Gly Glu Ser Pro Thr Gln Leu Pro Ser Arg Glu Asp 
305                 310                 315                 320 


Leu 
    


<210>  3499
<211>  325
<212>  PRT
<213>  Homo Sapiens

<400>  3499

Met Arg Leu Pro Arg Arg Ala Ala Leu Gly Leu Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Leu Pro Pro Ala Pro Glu Ala Ala Lys Lys Pro Thr Pro Cys His 
            20                  25                  30          


Arg Cys Arg Gly Leu Val Asp Lys Phe Asn Gln Gly Met Val Asp Thr 
        35                  40                  45              


Ala Lys Lys Asn Phe Gly Gly Gly Asn Thr Ala Trp Glu Glu Lys Thr 
    50                  55                  60                  


Leu Ser Lys Tyr Glu Ser Ser Glu Ile Arg Leu Leu Glu Ile Leu Glu 
65                  70                  75                  80  


Gly Leu Cys Glu Ser Ser Asp Phe Glu Cys Asn Gln Met Leu Glu Ala 
                85                  90                  95      


Gln Glu Glu His Leu Glu Ala Trp Trp Leu Gln Leu Lys Ser Glu Tyr 
            100                 105                 110         


Pro Asp Leu Phe Glu Trp Phe Cys Val Lys Thr Leu Lys Val Cys Cys 
        115                 120                 125             


Ser Pro Gly Thr Tyr Gly Pro Asp Cys Leu Ala Cys Gln Gly Gly Ser 
    130                 135                 140                 


Gln Arg Pro Cys Ser Gly Asn Gly His Cys Ser Gly Asp Gly Ser Arg 
145                 150                 155                 160 


Gln Gly Asp Gly Ser Cys Arg Cys His Met Gly Tyr Gln Gly Pro Leu 
                165                 170                 175     


Cys Thr Asp Cys Met Asp Gly Tyr Phe Ser Ser Leu Arg Asn Glu Thr 
            180                 185                 190         


His Ser Ile Cys Thr Ala Cys Asp Glu Ser Cys Lys Thr Cys Ser Gly 
        195                 200                 205             


Leu Thr Asn Arg Asp Cys Gly Glu Cys Glu Val Gly Trp Val Leu Asp 
    210                 215                 220                 


Glu Gly Ala Cys Val Glu Cys Asp Ser Ser Cys Val Gly Cys Thr Gly 
225                 230                 235                 240 


Glu Gly Pro Gly Asn Cys Lys Glu Cys Ile Ser Gly Tyr Ala Arg Glu 
                245                 250                 255     


His Gly Gln Cys Ala Asp Val Asp Glu Cys Ser Leu Ala Glu Lys Thr 
            260                 265                 270         


Cys Val Arg Lys Asn Glu Asn Cys Tyr Asn Thr Pro Gly Ser Tyr Val 
        275                 280                 285             


Cys Val Cys Pro Asp Gly Phe Glu Glu Thr Glu Asp Ala Cys Val Pro 
    290                 295                 300                 


Pro Ala Glu Ala Glu Ala Thr Glu Gly Glu Ser Pro Thr Gln Leu Pro 
305                 310                 315                 320 


Ser Arg Glu Asp Leu 
                325 


<210>  3500
<211>  402
<212>  PRT
<213>  Homo Sapiens

<400>  3500

Met Arg Leu Pro Arg Arg Ala Ala Leu Gly Leu Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Leu Pro Pro Ala Pro Glu Ala Ala Lys Lys Pro Thr Pro Cys His 
            20                  25                  30          


Arg Cys Arg Gly Leu Val Asp Lys Phe Asn Gln Gly Met Val Asp Thr 
        35                  40                  45              


Ala Lys Lys Asn Phe Gly Gly Gly Asn Thr Ala Trp Glu Glu Lys Thr 
    50                  55                  60                  


Leu Ser Lys Tyr Glu Ser Ser Glu Ile Arg Leu Leu Glu Ile Leu Glu 
65                  70                  75                  80  


Gly Leu Cys Glu Ser Ser Asp Phe Glu Cys Asn Gln Met Leu Glu Ala 
                85                  90                  95      


Gln Glu Glu His Leu Glu Ala Trp Trp Leu Gln Leu Lys Ser Glu Tyr 
            100                 105                 110         


Pro Asp Leu Phe Glu Trp Phe Cys Val Lys Thr Leu Lys Val Cys Cys 
        115                 120                 125             


Ser Pro Gly Thr Tyr Gly Pro Asp Cys Leu Ala Cys Gln Gly Gly Ser 
    130                 135                 140                 


Gln Arg Pro Cys Ser Gly Asn Gly His Cys Ser Gly Asp Gly Ser Arg 
145                 150                 155                 160 


Gln Gly Asp Gly Ser Cys Arg Cys His Met Gly Tyr Gln Gly Pro Leu 
                165                 170                 175     


Cys Thr Asp Cys Met Asp Gly Tyr Phe Ser Ser Leu Arg Asn Glu Thr 
            180                 185                 190         


His Ser Ile Cys Thr Val Arg Thr Gly Leu Ser Asp Ser Tyr Pro Pro 
        195                 200                 205             


Cys Cys Leu Ser Leu Gly Cys Trp Arg Gly Val Gly His Ala Trp Ile 
    210                 215                 220                 


Arg Gly Arg Asn Thr His Thr Gln Pro Gly Tyr Ser Ser Arg Val Trp 
225                 230                 235                 240 


Ile Ala Ala Phe Ser Pro Ala Cys Asp Glu Ser Cys Lys Thr Cys Ser 
                245                 250                 255     


Gly Leu Thr Asn Arg Asp Cys Gly Glu Cys Glu Val Gly Trp Val Leu 
            260                 265                 270         


Asp Glu Gly Ala Cys Val Asp Val Asp Glu Cys Ala Ala Glu Pro Pro 
        275                 280                 285             


Pro Cys Ser Ala Ala Gln Phe Cys Lys Asn Ala Asn Gly Ser Tyr Thr 
    290                 295                 300                 


Cys Glu Glu Cys Asp Ser Ser Cys Val Gly Cys Thr Gly Glu Gly Pro 
305                 310                 315                 320 


Gly Asn Cys Lys Glu Cys Ile Ser Gly Tyr Ala Arg Glu His Gly Gln 
                325                 330                 335     


Cys Ala Asp Val Asp Glu Cys Ser Leu Ala Glu Lys Thr Cys Val Arg 
            340                 345                 350         


Lys Asn Glu Asn Cys Tyr Asn Thr Pro Gly Ser Tyr Val Cys Val Cys 
        355                 360                 365             


Pro Asp Gly Phe Glu Glu Thr Glu Asp Ala Cys Val Pro Pro Ala Glu 
    370                 375                 380                 


Ala Glu Ala Thr Glu Gly Glu Ser Pro Thr Gln Leu Pro Ser Arg Glu 
385                 390                 395                 400 


Asp Leu 
        


<210>  3501
<211>  196
<212>  PRT
<213>  Homo Sapiens

<400>  3501

Met Arg Leu Pro Leu Leu Val Ser Ala Gly Val Leu Leu Val Ala Leu 
1               5                   10                  15      


Leu Pro Cys Pro Pro Cys Arg Ala Leu Leu Ser Arg Gly Pro Val Pro 
            20                  25                  30          


Gly Ala Arg Gln Ala Pro Gln His Pro Gln Pro Leu Asp Phe Phe Gln 
        35                  40                  45              


Pro Pro Pro Gln Ser Glu Gln Pro Gln Gln Pro Gln Ala Arg Pro Val 
    50                  55                  60                  


Leu Leu Arg Met Gly Glu Glu Tyr Phe Leu Arg Leu Gly Asn Leu Asn 
65                  70                  75                  80  


Lys Ser Pro Ala Ala Pro Leu Ser Pro Ala Ser Ser Leu Leu Ala Gly 
                85                  90                  95      


Gly Ser Gly Ser Arg Pro Ser Pro Glu Gln Ala Thr Ala Asn Phe Phe 
            100                 105                 110         


Arg Val Leu Leu Gln Gln Leu Leu Leu Pro Arg Arg Ser Leu Asp Ser 
        115                 120                 125             


Pro Ala Ala Leu Ala Glu Arg Gly Ala Arg Asn Ala Leu Gly Gly His 
    130                 135                 140                 


Gln Glu Ala Pro Glu Arg Glu Arg Arg Ser Glu Glu Pro Pro Ile Ser 
145                 150                 155                 160 


Leu Asp Leu Thr Phe His Leu Leu Arg Glu Val Leu Glu Met Ala Arg 
                165                 170                 175     


Ala Glu Gln Leu Ala Gln Gln Ala His Ser Asn Arg Lys Leu Met Glu 
            180                 185                 190         


Ile Ile Gly Lys 
        195     


<210>  3502
<211>  322
<212>  PRT
<213>  Homo Sapiens

<400>  3502

Met Ser Pro Asn Phe Lys Leu Gln Cys His Phe Ile Leu Ile Phe Leu 
1               5                   10                  15      


Thr Ala Leu Arg Gly Glu Ser Arg Tyr Leu Glu Leu Arg Glu Ala Ala 
            20                  25                  30          


Asp Tyr Asp Pro Phe Leu Leu Phe Ser Ala Asn Leu Lys Arg Glu Leu 
        35                  40                  45              


Ala Gly Glu Gln Pro Tyr Arg Arg Ala Leu Arg Cys Leu Asp Met Leu 
    50                  55                  60                  


Ser Leu Gln Gly Gln Phe Thr Phe Thr Ala Asp Arg Pro Gln Leu His 
65                  70                  75                  80  


Cys Ala Ala Phe Phe Ile Ser Glu Pro Glu Glu Phe Ile Thr Ile His 
                85                  90                  95      


Tyr Asp Gln Val Ser Ile Asp Cys Gln Gly Gly Asp Phe Leu Lys Val 
            100                 105                 110         


Phe Asp Gly Trp Ile Leu Lys Gly Glu Lys Phe Pro Ser Ser Gln Asp 
        115                 120                 125             


His Pro Leu Pro Ser Ala Glu Arg Tyr Ile Asp Phe Cys Glu Ser Gly 
    130                 135                 140                 


Leu Ser Arg Arg Ser Ile Arg Ser Ser Gln Asn Val Ala Met Ile Phe 
145                 150                 155                 160 


Phe Arg Val His Glu Pro Gly Asn Gly Phe Thr Leu Thr Ile Lys Thr 
                165                 170                 175     


Asp Pro Asn Leu Phe Pro Cys Asn Val Ile Ser Gln Thr Pro Asn Gly 
            180                 185                 190         


Lys Phe Thr Leu Val Val Pro His Gln His Arg Asn Cys Ser Phe Ser 
        195                 200                 205             


Ile Ile Tyr Pro Val Val Ile Lys Ile Ser Asp Leu Thr Leu Gly His 
    210                 215                 220                 


Val Asn Gly Leu Gln Leu Lys Lys Ser Ser Ala Gly Cys Glu Gly Ile 
225                 230                 235                 240 


Gly Asp Phe Val Glu Leu Leu Gly Gly Thr Gly Leu Asp Pro Ser Lys 
                245                 250                 255     


Met Thr Pro Leu Ala Asp Leu Cys Tyr Pro Phe His Gly Pro Ala Gln 
            260                 265                 270         


Met Lys Val Gly Cys Asp Asn Thr Val Val Arg Met Val Ser Ser Gly 
        275                 280                 285             


Lys His Val Asn Arg Val Thr Phe Glu Tyr Arg Gln Leu Glu Pro Tyr 
    290                 295                 300                 


Glu Leu Glu Asn Pro Asn Gly Asn Ser Ile Gly Glu Phe Cys Leu Ser 
305                 310                 315                 320 


Gly Leu 
        


<210>  3503
<211>  238
<212>  PRT
<213>  Homo Sapiens

<400>  3503

Met Ser Pro Asn Phe Lys Leu Gln Cys His Phe Ile Leu Ile Phe Leu 
1               5                   10                  15      


Thr Ala Leu Arg Gly Glu Ser Arg Tyr Leu Glu Leu Arg Glu Ala Ala 
            20                  25                  30          


Asp Tyr Asp Pro Phe Leu Leu Phe Ser Ala Asn Leu Lys Arg Glu Leu 
        35                  40                  45              


Ala Gly Glu Gln Pro Tyr Arg Arg Ala Leu Arg Cys Leu Asp Met Leu 
    50                  55                  60                  


Ser Leu Gln Gly Gln Phe Thr Phe Thr Ala Asp Arg Pro Gln Leu His 
65                  70                  75                  80  


Cys Ala Ala Phe Phe Ile Ser Glu Pro Glu Glu Phe Ile Thr Ile His 
                85                  90                  95      


Tyr Asp Gln Val Ser Ile Asp Cys Gln Gly Gly Asp Phe Leu Lys Val 
            100                 105                 110         


Phe Asp Gly Trp Ile Leu Lys Gly Glu Lys Phe Pro Ser Ser Gln Asp 
        115                 120                 125             


His Pro Leu Pro Ser Ala Glu Arg Tyr Ile Asp Phe Cys Glu Ser Gly 
    130                 135                 140                 


Leu Ser Arg Arg Ser Ile Arg Ser Ser Gln Asn Val Ala Met Ile Phe 
145                 150                 155                 160 


Phe Arg Val His Glu Pro Gly Asn Gly Phe Thr Leu Thr Ile Lys Thr 
                165                 170                 175     


Asp Pro Asn Leu Phe Pro Cys Asn Val Ile Ser Gln Thr Pro Asn Gly 
            180                 185                 190         


Lys Phe Thr Leu Val Val Pro His Gln His Arg Asn Cys Ser Phe Ser 
        195                 200                 205             


Ile Ile Tyr Pro Val Val Ile Lys Ile Ser Asp Leu Thr Leu Gly His 
    210                 215                 220                 


Val Asn Gly Leu Gln Leu Lys Val Ser Cys Leu Leu Val Ser 
225                 230                 235             


<210>  3504
<211>  375
<212>  PRT
<213>  Homo Sapiens

<400>  3504

Met Gly Gly His Pro Gln Leu Arg Leu Val Lys Ala Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Asn Pro Val Ser Ala Ser Leu Gln Asp Gln His Cys Glu Ser 
            20                  25                  30          


Leu Ser Leu Ala Ser Asn Ile Ser Asp Asn Gly Tyr Arg Glu Cys Leu 
        35                  40                  45              


Ala Asn Gly Ser Trp Ala Ala Arg Val Asn Tyr Ser Glu Cys Gln Glu 
    50                  55                  60                  


Ile Leu Asn Glu Glu Lys Lys Ser Lys Val His Tyr His Val Ala Val 
65                  70                  75                  80  


Ile Ile Asn Tyr Leu Gly His Cys Ile Ser Leu Val Ala Leu Leu Val 
                85                  90                  95      


Ala Phe Val Leu Phe Leu Arg Leu Arg Ser Ile Arg Cys Leu Arg Asn 
            100                 105                 110         


Ile Ile His Trp Asn Leu Ile Ser Ala Phe Ile Leu Arg Asn Ala Thr 
        115                 120                 125             


Trp Phe Val Val Gln Leu Thr Met Ser Pro Glu Val His Gln Ser Asn 
    130                 135                 140                 


Val Gly Trp Cys Arg Leu Val Thr Ala Ala Tyr Asn Tyr Phe His Val 
145                 150                 155                 160 


Thr Asn Phe Phe Trp Met Phe Gly Glu Gly Cys Tyr Leu His Thr Ala 
                165                 170                 175     


Ile Val Leu Thr Tyr Ser Thr Asp Arg Leu Arg Lys Trp Met Phe Ile 
            180                 185                 190         


Cys Ile Gly Trp Gly Val Pro Phe Pro Ile Ile Val Ala Trp Ala Ile 
        195                 200                 205             


Gly Lys Leu Tyr Tyr Asp Asn Glu Lys Cys Trp Phe Gly Lys Arg Pro 
    210                 215                 220                 


Gly Val Tyr Thr Asp Tyr Ile Tyr Gln Gly Pro Met Ile Leu Val Leu 
225                 230                 235                 240 


Leu Ile Asn Phe Ile Phe Leu Phe Asn Ile Val Arg Ile Leu Met Thr 
                245                 250                 255     


Lys Leu Arg Ala Ser Thr Thr Ser Glu Thr Ile Gln Tyr Arg Lys Ala 
            260                 265                 270         


Val Lys Ala Thr Leu Val Leu Leu Pro Leu Leu Gly Ile Thr Tyr Met 
        275                 280                 285             


Leu Phe Phe Val Asn Pro Gly Glu Asp Glu Val Ser Arg Val Val Phe 
    290                 295                 300                 


Ile Tyr Phe Asn Ser Phe Leu Glu Ser Phe Gln Gly Phe Phe Val Ser 
305                 310                 315                 320 


Val Phe Tyr Cys Phe Leu Asn Ser Glu Val Arg Ser Ala Ile Arg Lys 
                325                 330                 335     


Arg Trp His Arg Trp Gln Asp Lys His Ser Ile Arg Ala Arg Val Ala 
            340                 345                 350         


Arg Ala Met Ser Ile Pro Thr Ser Pro Thr Arg Val Ser Phe His Ser 
        355                 360                 365             


Ile Lys Gln Ser Thr Ala Val 
    370                 375 


<210>  3505
<211>  154
<212>  PRT
<213>  Homo Sapiens

<400>  3505

Met Gly Gly His Pro Gln Leu Arg Leu Val Lys Ala Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Asn Pro Val Ser Ala Ser Leu Gln Asp Gln His Cys Glu Ser 
            20                  25                  30          


Leu Ser Leu Ala Ser Asn Ile Ser Glu Lys Lys Gln Gly Ala Leu Pro 
        35                  40                  45              


Cys Arg Ser His His Gln Leu Pro Gly Pro Leu Tyr Leu Pro Gly Gly 
    50                  55                  60                  


Pro Pro Gly Gly Leu Cys Pro Leu Ser Ala Ala Gln Glu His Pro Val 
65                  70                  75                  80  


Pro Ala Lys His His Pro Leu Glu Pro His Leu Arg Leu His Pro Ala 
                85                  90                  95      


Gln Arg His Leu Val Arg Gly Pro Ala Asn His Glu Pro Arg Gly Pro 
            100                 105                 110         


Pro Glu Gln Arg Gly Leu Val Gln Val Gly Asp Ser Arg Leu Gln Leu 
        115                 120                 125             


Leu Pro Cys Asp Gln Leu Leu Leu Asp Val Arg Arg Gly Leu Leu Pro 
    130                 135                 140                 


Ala His Ser His Arg Ala His Leu Leu His 
145                 150                 


<210>  3506
<211>  430
<212>  PRT
<213>  Homo Sapiens

<400>  3506

Met Gly Gly His Pro Gln Leu Arg Leu Val Lys Ala Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Asn Pro Val Ser Ala Ser Leu Gln Asp Gln His Cys Glu Ser 
            20                  25                  30          


Leu Ser Leu Ala Ser Asn Ile Ser Gly Leu Gln Cys Asn Ala Ser Val 
        35                  40                  45              


Asp Leu Ile Gly Thr Cys Trp Pro Arg Ser Pro Ala Gly Gln Leu Val 
    50                  55                  60                  


Val Arg Pro Cys Pro Ala Phe Phe Tyr Gly Val Arg Tyr Asn Thr Thr 
65                  70                  75                  80  


Asn Asn Gly Tyr Arg Glu Cys Leu Ala Asn Gly Ser Trp Ala Ala Arg 
                85                  90                  95      


Val Asn Tyr Ser Glu Cys Gln Glu Ile Leu Asn Glu Glu Lys Lys Ser 
            100                 105                 110         


Lys Val His Tyr His Val Ala Val Ile Ile Asn Tyr Leu Gly His Cys 
        115                 120                 125             


Ile Ser Leu Val Ala Leu Leu Val Ala Phe Val Leu Phe Leu Arg Leu 
    130                 135                 140                 


Arg Pro Gly Cys Thr His Trp Gly Asp Gln Ala Asp Gly Ala Leu Glu 
145                 150                 155                 160 


Val Gly Ala Pro Trp Ser Gly Ala Pro Phe Gln Val Arg Arg Ser Ile 
                165                 170                 175     


Arg Cys Leu Arg Asn Ile Ile His Trp Asn Leu Ile Ser Ala Phe Ile 
            180                 185                 190         


Leu Arg Asn Ala Thr Trp Phe Val Val Gln Leu Thr Met Ser Pro Glu 
        195                 200                 205             


Val His Gln Ser Asn Val Gly Trp Cys Arg Leu Val Thr Ala Ala Tyr 
    210                 215                 220                 


Asn Tyr Phe His Val Thr Asn Phe Phe Trp Met Phe Gly Glu Gly Cys 
225                 230                 235                 240 


Tyr Leu His Thr Ala Ile Val Leu Thr Tyr Ser Thr Asp Arg Leu Arg 
                245                 250                 255     


Lys Trp Met Phe Ile Cys Ile Gly Trp Gly Val Pro Phe Pro Ile Ile 
            260                 265                 270         


Val Ala Trp Ala Ile Gly Lys Leu Tyr Tyr Asp Asn Glu Lys Cys Trp 
        275                 280                 285             


Phe Gly Lys Arg Pro Gly Val Tyr Thr Asp Tyr Ile Tyr Gln Gly Pro 
    290                 295                 300                 


Met Ile Leu Val Leu Leu Ile Asn Phe Ile Phe Leu Phe Asn Ile Val 
305                 310                 315                 320 


Arg Ile Leu Met Thr Lys Leu Arg Ala Ser Thr Thr Ser Glu Thr Ile 
                325                 330                 335     


Gln Tyr Arg Lys Ala Val Lys Ala Thr Leu Val Leu Leu Pro Leu Leu 
            340                 345                 350         


Gly Ile Thr Tyr Met Leu Phe Phe Val Asn Pro Gly Glu Asp Glu Val 
        355                 360                 365             


Ser Arg Val Val Phe Ile Tyr Phe Asn Ser Phe Leu Glu Ser Phe Gln 
    370                 375                 380                 


Val Arg Ser Ala Ile Arg Lys Arg Trp His Arg Trp Gln Asp Lys His 
385                 390                 395                 400 


Ser Ile Arg Ala Arg Val Ala Arg Ala Met Ser Ile Pro Thr Ser Pro 
                405                 410                 415     


Thr Arg Val Ser Phe His Ser Ile Lys Gln Ser Thr Ala Val 
            420                 425                 430 


<210>  3507
<211>  444
<212>  PRT
<213>  Homo Sapiens

<400>  3507

Met Gly Gly His Pro Gln Leu Arg Leu Val Lys Ala Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Asn Pro Val Ser Ala Ser Leu Gln Asp Gln His Cys Glu Ser 
            20                  25                  30          


Leu Ser Leu Ala Ser Asn Ile Ser Gly Leu Gln Cys Asn Ala Ser Val 
        35                  40                  45              


Asp Leu Ile Gly Thr Cys Trp Pro Arg Ser Pro Ala Gly Gln Leu Val 
    50                  55                  60                  


Val Arg Pro Cys Pro Ala Phe Phe Tyr Gly Val Arg Tyr Asn Thr Thr 
65                  70                  75                  80  


Asn Asn Gly Tyr Arg Glu Cys Leu Ala Asn Gly Ser Trp Ala Ala Arg 
                85                  90                  95      


Val Asn Tyr Ser Glu Cys Gln Glu Ile Leu Asn Glu Glu Lys Lys Ser 
            100                 105                 110         


Lys Val His Tyr His Val Ala Val Ile Ile Asn Tyr Leu Gly His Cys 
        115                 120                 125             


Ile Ser Leu Val Ala Leu Leu Val Ala Phe Val Leu Phe Leu Arg Leu 
    130                 135                 140                 


Arg Pro Gly Cys Thr His Trp Gly Asp Gln Ala Asp Gly Ala Leu Glu 
145                 150                 155                 160 


Val Gly Ala Pro Trp Ser Gly Ala Pro Phe Gln Val Arg Arg Ser Ile 
                165                 170                 175     


Arg Cys Leu Arg Asn Ile Ile His Trp Asn Leu Ile Ser Ala Phe Ile 
            180                 185                 190         


Leu Arg Asn Ala Thr Trp Phe Val Val Gln Leu Thr Met Ser Pro Glu 
        195                 200                 205             


Val His Gln Ser Asn Val Gly Trp Cys Arg Leu Val Thr Ala Ala Tyr 
    210                 215                 220                 


Asn Tyr Phe His Val Thr Asn Phe Phe Trp Met Phe Gly Glu Gly Cys 
225                 230                 235                 240 


Tyr Leu His Thr Ala Ile Val Leu Thr Tyr Ser Thr Asp Arg Leu Arg 
                245                 250                 255     


Lys Trp Met Phe Ile Cys Ile Gly Trp Gly Val Pro Phe Pro Ile Ile 
            260                 265                 270         


Val Ala Trp Ala Ile Gly Lys Leu Tyr Tyr Asp Asn Glu Lys Cys Trp 
        275                 280                 285             


Phe Gly Lys Arg Pro Gly Val Tyr Thr Asp Tyr Ile Tyr Gln Gly Pro 
    290                 295                 300                 


Met Ile Leu Val Leu Leu Ile Asn Phe Ile Phe Leu Phe Asn Ile Val 
305                 310                 315                 320 


Arg Ile Leu Met Thr Lys Leu Arg Ala Ser Thr Thr Ser Glu Thr Ile 
                325                 330                 335     


Gln Tyr Arg Lys Ala Val Lys Ala Thr Leu Val Leu Leu Pro Leu Leu 
            340                 345                 350         


Gly Ile Thr Tyr Met Leu Phe Phe Val Asn Pro Gly Glu Asp Glu Val 
        355                 360                 365             


Ser Arg Val Val Phe Ile Tyr Phe Asn Ser Phe Leu Glu Ser Phe Gln 
    370                 375                 380                 


Gly Phe Phe Val Ser Val Phe Tyr Cys Phe Leu Asn Ser Glu Val Arg 
385                 390                 395                 400 


Ser Ala Ile Arg Lys Arg Trp His Arg Trp Gln Asp Lys His Ser Ile 
                405                 410                 415     


Arg Ala Arg Val Ala Arg Ala Met Ser Ile Pro Thr Ser Pro Thr Arg 
            420                 425                 430         


Val Ser Phe His Ser Ile Lys Gln Ser Thr Ala Val 
        435                 440                 


<210>  3508
<211>  415
<212>  PRT
<213>  Homo Sapiens

<400>  3508

Met Gly Gly His Pro Gln Leu Arg Leu Val Lys Ala Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Asn Pro Val Ser Ala Ser Leu Gln Asp Gln His Cys Glu Ser 
            20                  25                  30          


Leu Ser Leu Ala Ser Asn Ile Ser Gly Leu Gln Cys Asn Ala Ser Val 
        35                  40                  45              


Asp Leu Ile Gly Thr Cys Trp Pro Arg Ser Pro Ala Gly Gln Leu Val 
    50                  55                  60                  


Val Arg Pro Cys Pro Ala Phe Phe Tyr Gly Val Arg Tyr Asn Thr Thr 
65                  70                  75                  80  


Asn Asn Gly Tyr Arg Glu Cys Leu Ala Asn Gly Ser Trp Ala Ala Arg 
                85                  90                  95      


Val Asn Tyr Ser Glu Cys Gln Glu Ile Leu Asn Glu Glu Lys Lys Ser 
            100                 105                 110         


Lys Val His Tyr His Val Ala Val Ile Ile Asn Tyr Leu Gly His Cys 
        115                 120                 125             


Ile Ser Leu Val Ala Leu Leu Val Ala Phe Val Leu Phe Leu Arg Leu 
    130                 135                 140                 


Arg Ser Ile Arg Cys Leu Arg Asn Ile Ile His Trp Asn Leu Ile Ser 
145                 150                 155                 160 


Ala Phe Ile Leu Arg Asn Ala Thr Trp Phe Val Val Gln Leu Thr Met 
                165                 170                 175     


Ser Pro Glu Val His Gln Ser Asn Val Gly Trp Cys Arg Leu Val Thr 
            180                 185                 190         


Ala Ala Tyr Asn Tyr Phe His Val Thr Asn Phe Phe Trp Met Phe Gly 
        195                 200                 205             


Glu Gly Cys Tyr Leu His Thr Ala Ile Val Leu Thr Tyr Ser Thr Asp 
    210                 215                 220                 


Arg Leu Arg Lys Trp Met Phe Ile Cys Ile Gly Trp Gly Val Pro Phe 
225                 230                 235                 240 


Pro Ile Ile Val Ala Trp Ala Ile Gly Lys Leu Tyr Tyr Asp Asn Glu 
                245                 250                 255     


Lys Cys Trp Phe Gly Lys Arg Pro Gly Val Tyr Thr Asp Tyr Ile Tyr 
            260                 265                 270         


Gln Gly Pro Met Ile Leu Val Leu Leu Ile Asn Phe Ile Phe Leu Phe 
        275                 280                 285             


Asn Ile Val Arg Ile Leu Met Thr Lys Leu Arg Ala Ser Thr Thr Ser 
    290                 295                 300                 


Glu Thr Ile Gln Tyr Arg Lys Ala Val Lys Ala Thr Leu Val Leu Leu 
305                 310                 315                 320 


Pro Leu Leu Gly Ile Thr Tyr Met Leu Phe Phe Val Asn Pro Gly Glu 
                325                 330                 335     


Asp Glu Val Ser Arg Val Val Phe Ile Tyr Phe Asn Ser Phe Leu Glu 
            340                 345                 350         


Ser Phe Gln Gly Phe Phe Val Ser Val Phe Tyr Cys Phe Leu Asn Ser 
        355                 360                 365             


Glu Val Arg Ser Ala Ile Arg Lys Arg Trp His Arg Trp Gln Asp Lys 
    370                 375                 380                 


His Ser Ile Arg Ala Arg Val Ala Arg Ala Met Ser Ile Pro Thr Ser 
385                 390                 395                 400 


Pro Thr Arg Val Ser Phe His Ser Ile Lys Gln Ser Thr Ala Val 
                405                 410                 415 


<210>  3509
<211>  401
<212>  PRT
<213>  Homo Sapiens

<400>  3509

Met Gly Gly His Pro Gln Leu Arg Leu Val Lys Ala Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Asn Pro Val Ser Ala Ser Leu Gln Asp Gln His Cys Glu Ser 
            20                  25                  30          


Leu Ser Leu Ala Ser Asn Ile Ser Gly Leu Gln Cys Asn Ala Ser Val 
        35                  40                  45              


Asp Leu Ile Gly Thr Cys Trp Pro Arg Ser Pro Ala Gly Gln Leu Val 
    50                  55                  60                  


Val Arg Pro Cys Pro Ala Phe Phe Tyr Gly Val Arg Tyr Asn Thr Thr 
65                  70                  75                  80  


Asn Asn Gly Tyr Arg Glu Cys Leu Ala Asn Gly Ser Trp Ala Ala Arg 
                85                  90                  95      


Val Asn Tyr Ser Glu Cys Gln Glu Ile Leu Asn Glu Glu Lys Lys Ser 
            100                 105                 110         


Lys Val His Tyr His Val Ala Val Ile Ile Asn Tyr Leu Gly His Cys 
        115                 120                 125             


Ile Ser Leu Val Ala Leu Leu Val Ala Phe Val Leu Phe Leu Arg Leu 
    130                 135                 140                 


Arg Ser Ile Arg Cys Leu Arg Asn Ile Ile His Trp Asn Leu Ile Ser 
145                 150                 155                 160 


Ala Phe Ile Leu Arg Asn Ala Thr Trp Phe Val Val Gln Leu Thr Met 
                165                 170                 175     


Ser Pro Glu Val His Gln Ser Asn Val Gly Trp Cys Arg Leu Val Thr 
            180                 185                 190         


Ala Ala Tyr Asn Tyr Phe His Val Thr Asn Phe Phe Trp Met Phe Gly 
        195                 200                 205             


Glu Gly Cys Tyr Leu His Thr Ala Ile Val Leu Thr Tyr Ser Thr Asp 
    210                 215                 220                 


Arg Leu Arg Lys Trp Met Phe Ile Cys Ile Gly Trp Gly Val Pro Phe 
225                 230                 235                 240 


Pro Ile Ile Val Ala Trp Ala Ile Gly Lys Leu Tyr Tyr Asp Asn Glu 
                245                 250                 255     


Lys Cys Trp Phe Gly Lys Arg Pro Gly Val Tyr Thr Asp Tyr Ile Tyr 
            260                 265                 270         


Gln Gly Pro Met Ile Leu Val Leu Leu Ile Asn Phe Ile Phe Leu Phe 
        275                 280                 285             


Asn Ile Val Arg Ile Leu Met Thr Lys Leu Arg Ala Ser Thr Thr Ser 
    290                 295                 300                 


Glu Thr Ile Gln Tyr Arg Lys Ala Val Lys Ala Thr Leu Val Leu Leu 
305                 310                 315                 320 


Pro Leu Leu Gly Ile Thr Tyr Met Leu Phe Phe Val Asn Pro Gly Glu 
                325                 330                 335     


Asp Glu Val Ser Arg Val Val Phe Ile Tyr Phe Asn Ser Phe Leu Glu 
            340                 345                 350         


Ser Phe Gln Val Arg Ser Ala Ile Arg Lys Arg Trp His Arg Trp Gln 
        355                 360                 365             


Asp Lys His Ser Ile Arg Ala Arg Val Ala Arg Ala Met Ser Ile Pro 
    370                 375                 380                 


Thr Ser Pro Thr Arg Val Ser Phe His Ser Ile Lys Gln Ser Thr Ala 
385                 390                 395                 400 


Val 
    


<210>  3510
<211>  145
<212>  PRT
<213>  Homo Sapiens

<400>  3510

Met Gly Gly His Pro Gln Leu Arg Leu Val Lys Ala Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Asn Pro Val Ser Ala Ser Leu Gln Asp Gln His Cys Glu Ser 
            20                  25                  30          


Leu Ser Leu Ala Ser Asn Ile Ser Gly Leu Gln Cys Asn Ala Ser Val 
        35                  40                  45              


Asp Leu Ile Gly Thr Cys Trp Pro Arg Ser Pro Ala Gly Gln Leu Val 
    50                  55                  60                  


Val Arg Pro Cys Pro Ala Phe Phe Tyr Gly Val Arg Tyr Asn Thr Thr 
65                  70                  75                  80  


Asn Asn Gly Tyr Arg Glu Cys Leu Ala Asn Gly Ser Trp Ala Ala Arg 
                85                  90                  95      


Val Asn Tyr Ser Glu Cys Gln Glu Ile Leu Asn Glu Glu Lys Lys Ser 
            100                 105                 110         


Lys Val His Tyr His Val Ala Val Ile Ile Asn Tyr Leu Gly His Cys 
        115                 120                 125             


Ile Ser Leu Val Ala Leu Leu Val Ala Phe Val Leu Phe Leu Arg Leu 
    130                 135                 140                 


Ser 
145 


<210>  3511
<211>  314
<212>  PRT
<213>  Homo Sapiens

<400>  3511

Met Val Ser Ala Thr Ile Pro Gln Lys Lys Ser Lys Val His Tyr His 
1               5                   10                  15      


Val Ala Val Ile Ile Asn Tyr Leu Gly His Cys Ile Ser Leu Val Ala 
            20                  25                  30          


Leu Leu Val Ala Phe Val Leu Phe Leu Arg Leu Arg Ser Ile Arg Cys 
        35                  40                  45              


Leu Arg Asn Ile Ile His Trp Asn Leu Ile Ser Ala Phe Ile Leu Arg 
    50                  55                  60                  


Asn Ala Thr Trp Phe Val Val Gln Leu Thr Met Ser Pro Glu Val His 
65                  70                  75                  80  


Gln Ser Asn Val Gly Trp Cys Arg Leu Val Thr Ala Ala Tyr Asn Tyr 
                85                  90                  95      


Phe His Val Thr Asn Phe Phe Trp Met Phe Gly Glu Gly Cys Tyr Leu 
            100                 105                 110         


His Thr Ala Ile Val Leu Thr Tyr Ser Thr Asp Arg Leu Arg Lys Trp 
        115                 120                 125             


Met Phe Ile Cys Ile Gly Trp Gly Val Pro Phe Pro Ile Ile Val Ala 
    130                 135                 140                 


Trp Ala Ile Gly Lys Leu Tyr Tyr Asp Asn Glu Lys Cys Trp Phe Gly 
145                 150                 155                 160 


Lys Arg Pro Gly Val Tyr Thr Asp Tyr Ile Tyr Gln Gly Pro Met Ile 
                165                 170                 175     


Leu Val Leu Leu Ile Asn Phe Ile Phe Leu Phe Asn Ile Val Arg Ile 
            180                 185                 190         


Leu Met Thr Lys Leu Arg Ala Ser Thr Thr Ser Glu Thr Ile Gln Tyr 
        195                 200                 205             


Arg Lys Ala Val Lys Ala Thr Leu Val Leu Leu Pro Leu Leu Gly Ile 
    210                 215                 220                 


Thr Tyr Met Leu Phe Phe Val Asn Pro Gly Glu Asp Glu Val Ser Arg 
225                 230                 235                 240 


Val Val Phe Ile Tyr Phe Asn Ser Phe Leu Glu Ser Phe Gln Gly Phe 
                245                 250                 255     


Phe Val Ser Val Phe Tyr Cys Phe Leu Asn Ser Glu Val Arg Ser Ala 
            260                 265                 270         


Ile Arg Lys Arg Trp His Arg Trp Gln Asp Lys His Ser Ile Arg Ala 
        275                 280                 285             


Arg Val Ala Arg Ala Met Ser Ile Pro Thr Ser Pro Thr Arg Val Ser 
    290                 295                 300                 


Phe His Ser Ile Lys Gln Ser Thr Ala Val 
305                 310                 


<210>  3512
<211>  52
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3512

Xaa Cys Trp Phe Gly Lys Arg Pro Gly Val Tyr Thr Asp Tyr Ile Tyr 
1               5                   10                  15      


Gln Gly Pro Met Ile Leu Val Leu Leu Glu Gly Cys Glu Ser His Ser 
            20                  25                  30          


Gly Ala Ala Ala Pro Pro Gly His His Leu His Ala Val Leu Arg Gln 
        35                  40                  45              


Ser Arg Gly Gly 
    50          


<210>  3513
<211>  75
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3513

Xaa Cys Trp Phe Gly Lys Arg Pro Gly Val Tyr Thr Asp Tyr Ile Tyr 
1               5                   10                  15      


Gln Gly Pro Met Ile Leu Val Leu Leu Ile Asn Phe Ile Phe Leu Phe 
            20                  25                  30          


Asn Ile Val Arg Ile Leu Met Thr Lys Leu Arg Ala Ser Thr Thr Ser 
        35                  40                  45              


Glu Thr Ile Gln Tyr Arg Ala Ser Leu Cys Leu Cys Ser Thr Val Ser 
    50                  55                  60                  


Ser Ile Val Arg Ser Val Leu Pro Ser Gly Arg 
65                  70                  75  


<210>  3514
<211>  93
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3514

Xaa Ser Leu Ala Ser Asn Ile Ser Gly Leu Gln Cys Asn Ala Ser Val 
1               5                   10                  15      


Asp Leu Ile Gly Thr Cys Trp Pro Arg Ser Pro Ala Gly Gln Leu Val 
            20                  25                  30          


Val Arg Pro Cys Pro Ala Phe Phe Tyr Gly Val Arg Tyr Asn Thr Thr 
        35                  40                  45              


Asn Asn Gly Tyr Arg Glu Cys Leu Ala Asn Gly Ser Trp Ala Ala Arg 
    50                  55                  60                  


Val Asn Tyr Ser Glu Cys Gln Glu Ile Leu Asn Glu Glu Glu Pro Gly 
65                  70                  75                  80  


Pro Gln Ala Gln Pro Gly Arg Ala His Arg Gly Gly Thr 
                85                  90              


<210>  3515
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  3515

Tyr Gly Val Arg Tyr Asn Thr Thr Asn Asn Gly Tyr Arg Glu Cys Leu 
1               5                   10                  15      


Ala Asn Gly Ser Trp Ala Ala Arg Val Asn Tyr Ser Glu Cys Gln Glu 
            20                  25                  30          


Ile Leu Asn Glu Glu Lys Lys Ser Lys Val His Tyr His Val Ala Val 
        35                  40                  45              


Ile Ile Asn Tyr Leu Gly His Cys Ile Ser Leu Val Ala Leu Leu Val 
    50                  55                  60                  


Ala Phe Val Leu Phe Leu Arg Leu Arg Ser Ile Arg Cys Leu Arg Asn 
65                  70                  75                  80  


Ile Ile His Trp Asn Leu Ile Ser Ala Phe Ile Leu Arg Asn Ala Thr 
                85                  90                  95      


Trp Phe Val Val Gln Leu Thr Met Ser Pro Glu Val His Gln Ser Asn 
            100                 105                 110         


Val Val Cys Pro Ser Pro Ser Leu Trp Pro Gly Pro Leu Gly Ser Cys 
        115                 120                 125             


Thr Thr Thr Met Arg Ser Ala Gly Leu Ala Lys Gly Leu Gly Cys Thr 
    130                 135                 140                 


Pro Thr Thr Ser Thr Arg Ala Pro 
145                 150         


<210>  3516
<211>  411
<212>  PRT
<213>  Homo Sapiens

<400>  3516

Met Asp Ala Ala Leu Leu His Ser Leu Leu Glu Ala Asn Cys Ser Leu 
1               5                   10                  15      


Ala Leu Ala Glu Glu Leu Leu Leu Asp Gly Trp Gly Pro Pro Leu Asp 
            20                  25                  30          


Pro Glu Gly Pro Tyr Ser Tyr Cys Asn Thr Thr Leu Asp Gln Ile Gly 
        35                  40                  45              


Thr Cys Trp Pro Arg Ser Ala Ala Gly Ala Leu Val Glu Arg Pro Cys 
    50                  55                  60                  


Pro Glu Tyr Phe Asn Gly Val Lys Tyr Asn Thr Thr Arg Asn Ala Tyr 
65                  70                  75                  80  


Arg Glu Cys Leu Glu Asn Gly Thr Trp Ala Ser Lys Ile Asn Tyr Ser 
                85                  90                  95      


Gln Cys Glu Pro Ile Leu Asp Asp Lys Gln Arg Lys Tyr Asp Leu His 
            100                 105                 110         


Tyr Arg Ile Ala Leu Val Val Asn Tyr Leu Gly His Cys Val Ser Val 
        115                 120                 125             


Ala Ala Leu Val Ala Ala Phe Leu Leu Phe Leu Ala Leu Arg Ser Ile 
    130                 135                 140                 


Arg Cys Leu Arg Asn Val Ile His Trp Asn Leu Ile Thr Thr Phe Ile 
145                 150                 155                 160 


Leu Arg Asn Val Met Trp Phe Leu Leu Gln Leu Val Asp His Glu Val 
                165                 170                 175     


His Glu Ser Asn Glu Val Trp Cys Arg Cys Ile Thr Thr Ile Phe Asn 
            180                 185                 190         


Tyr Phe Val Val Thr Asn Phe Phe Trp Met Phe Val Glu Gly Cys Tyr 
        195                 200                 205             


Leu His Thr Ala Ile Val Met Thr Tyr Ser Thr Glu Arg Leu Arg Lys 
    210                 215                 220                 


Cys Leu Phe Leu Phe Ile Gly Trp Cys Ile Pro Phe Pro Ile Ile Val 
225                 230                 235                 240 


Ala Trp Ala Ile Gly Lys Leu Tyr Tyr Glu Asn Glu Gln Cys Trp Phe 
                245                 250                 255     


Gly Lys Glu Pro Gly Asp Leu Val Asp Tyr Ile Tyr Gln Gly Pro Ile 
            260                 265                 270         


Ile Leu Val Leu Leu Ile Asn Phe Val Phe Leu Phe Asn Ile Val Arg 
        275                 280                 285             


Ile Leu Met Thr Lys Leu Arg Ala Ser Thr Thr Ser Glu Thr Ile Gln 
    290                 295                 300                 


Tyr Arg Lys Ala Val Lys Ala Thr Leu Val Leu Leu Pro Leu Leu Gly 
305                 310                 315                 320 


Ile Thr Tyr Met Leu Phe Phe Val Asn Pro Gly Glu Asp Asp Leu Ser 
                325                 330                 335     


Gln Ile Met Phe Ile Tyr Phe Asn Ser Phe Leu Gln Ser Phe Gln Gly 
            340                 345                 350         


Phe Phe Val Ser Val Phe Tyr Cys Phe Phe Asn Gly Glu Val Arg Ser 
        355                 360                 365             


Ala Val Arg Lys Arg Trp His Arg Trp Gln Asp His His Ser Leu Arg 
    370                 375                 380                 


Val Pro Met Ala Arg Ala Met Ser Ile Pro Thr Ser Pro Thr Arg Ile 
385                 390                 395                 400 


Ser Phe His Ser Ile Lys Gln Thr Ala Ala Val 
                405                 410     


<210>  3517
<211>  387
<212>  PRT
<213>  Homo Sapiens

<400>  3517

Met Asp Ala Ala Leu Leu His Ser Leu Leu Glu Ala Asn Cys Ser Leu 
1               5                   10                  15      


Ala Leu Ala Glu Glu Leu Leu Leu Asp Gly Trp Gly Pro Pro Leu Asp 
            20                  25                  30          


Pro Glu Gly Pro Tyr Ser Tyr Cys Asn Thr Thr Leu Asp Gln Ile Gly 
        35                  40                  45              


Thr Cys Trp Pro Arg Ser Ala Ala Gly Ala Leu Val Glu Arg Pro Cys 
    50                  55                  60                  


Pro Glu Tyr Phe Asn Gly Val Lys Tyr Asn Thr Thr Arg Asn Ala Tyr 
65                  70                  75                  80  


Arg Glu Cys Leu Glu Asn Gly Thr Trp Ala Ser Lys Ile Asn Tyr Ser 
                85                  90                  95      


Gln Cys Glu Pro Ile Leu Asp Asp Lys Gln Arg Lys Tyr Asp Leu His 
            100                 105                 110         


Tyr Arg Ile Ala Leu Val Val Asn Tyr Leu Gly His Cys Val Ser Val 
        115                 120                 125             


Ala Ala Leu Val Ala Ala Phe Leu Leu Phe Leu Ala Leu Arg Ser Ile 
    130                 135                 140                 


Arg Cys Leu Arg Asn Val Ile His Trp Asn Leu Ile Thr Thr Phe Ile 
145                 150                 155                 160 


Leu Arg Asn Val Met Trp Phe Leu Leu Gln Leu Val Asp His Glu Val 
                165                 170                 175     


His Glu Ser Asn Glu Val Trp Cys Arg Cys Ile Thr Thr Ile Phe Asn 
            180                 185                 190         


Tyr Phe Val Val Thr Asn Phe Phe Trp Met Phe Val Glu Gly Cys Tyr 
        195                 200                 205             


Leu His Thr Ala Ile Val Met Thr Tyr Ser Thr Glu Arg Leu Arg Lys 
    210                 215                 220                 


Cys Leu Phe Leu Phe Ile Gly Trp Cys Ile Pro Phe Pro Ile Ile Val 
225                 230                 235                 240 


Ala Trp Ala Ile Gly Lys Leu Tyr Tyr Glu Asn Glu Gln Cys Trp Phe 
                245                 250                 255     


Gly Lys Glu Pro Gly Asp Leu Val Asp Tyr Ile Tyr Gln Gly Pro Ile 
            260                 265                 270         


Ile Leu Val Leu Leu Ile Asn Phe Val Phe Leu Phe Asn Ile Val Arg 
        275                 280                 285             


Ile Leu Met Thr Lys Leu Arg Ala Ser Thr Thr Ser Glu Thr Ile Gln 
    290                 295                 300                 


Tyr Arg Lys Ala Val Lys Ala Thr Leu Val Leu Leu Pro Leu Leu Gly 
305                 310                 315                 320 


Ile Thr Tyr Met Leu Phe Phe Val Asn Pro Gly Glu Asp Asp Leu Ser 
                325                 330                 335     


Gln Ile Met Phe Ile Tyr Phe Asn Ser Phe Leu Gln Ser Phe Gln Gly 
            340                 345                 350         


Phe Phe Val Ser Val Phe Tyr Cys Phe Phe Asn Gly Glu Ser Trp Val 
        355                 360                 365             


Ser Lys Glu Ala Gln Ala Ala Gly Pro His Gly Arg Glu Lys Pro Glu 
    370                 375                 380                 


Gln Arg Trp 
385         


<210>  3518
<211>  397
<212>  PRT
<213>  Homo Sapiens

<400>  3518

Met Gly Arg Glu Pro Trp Pro Glu Asp Arg Asp Leu Gly Phe Pro Gln 
1               5                   10                  15      


Leu Phe Cys Gln Gly Pro Tyr Ser Tyr Cys Asn Thr Thr Leu Asp Gln 
            20                  25                  30          


Ile Gly Thr Cys Trp Pro Arg Ser Ala Ala Gly Ala Leu Val Glu Arg 
        35                  40                  45              


Pro Cys Pro Glu Tyr Phe Asn Gly Val Lys Tyr Asn Thr Thr Arg Asn 
    50                  55                  60                  


Ala Tyr Arg Glu Cys Leu Glu Asn Gly Thr Trp Ala Ser Lys Ile Asn 
65                  70                  75                  80  


Tyr Ser Gln Cys Glu Pro Ile Leu Asp Asp Lys Gln Arg Lys Tyr Asp 
                85                  90                  95      


Leu His Tyr Arg Ile Ala Leu Val Val Asn Tyr Leu Gly His Cys Val 
            100                 105                 110         


Ser Val Ala Ala Leu Val Ala Ala Phe Leu Leu Phe Leu Ala Leu Arg 
        115                 120                 125             


Ser Ile Arg Cys Leu Arg Asn Val Ile His Trp Asn Leu Ile Thr Thr 
    130                 135                 140                 


Phe Ile Leu Arg Asn Val Met Trp Phe Leu Leu Gln Leu Val Asp His 
145                 150                 155                 160 


Glu Val His Glu Ser Asn Glu Val Trp Cys Arg Cys Ile Thr Thr Ile 
                165                 170                 175     


Phe Asn Tyr Phe Val Val Thr Asn Phe Phe Trp Met Phe Val Glu Gly 
            180                 185                 190         


Cys Tyr Leu His Thr Ala Ile Val Met Thr Tyr Ser Thr Glu Arg Leu 
        195                 200                 205             


Arg Lys Cys Leu Phe Leu Phe Ile Gly Trp Cys Ile Pro Phe Pro Ile 
    210                 215                 220                 


Ile Val Ala Trp Ala Ile Gly Lys Leu Tyr Tyr Glu Asn Glu Gln Cys 
225                 230                 235                 240 


Trp Phe Gly Lys Glu Pro Gly Asp Leu Val Asp Tyr Ile Tyr Gln Gly 
                245                 250                 255     


Pro Ile Ile Leu Val Leu Leu Ile Asn Phe Val Phe Leu Phe Asn Ile 
            260                 265                 270         


Val Arg Ile Leu Met Thr Lys Leu Arg Ala Ser Thr Thr Ser Glu Thr 
        275                 280                 285             


Ile Gln Tyr Arg Lys Ala Val Lys Ala Thr Leu Val Leu Leu Pro Leu 
    290                 295                 300                 


Leu Gly Ile Thr Tyr Met Leu Phe Phe Val Asn Pro Gly Glu Asp Asp 
305                 310                 315                 320 


Leu Ser Gln Ile Met Phe Ile Tyr Phe Asn Ser Phe Leu Gln Ser Phe 
                325                 330                 335     


Gln Gly Phe Phe Val Ser Val Phe Tyr Cys Phe Phe Asn Gly Glu Val 
            340                 345                 350         


Arg Ser Ala Val Arg Lys Arg Trp His Arg Trp Gln Asp His His Ser 
        355                 360                 365             


Leu Arg Val Pro Met Ala Arg Ala Met Ser Ile Pro Thr Ser Pro Thr 
    370                 375                 380                 


Arg Ile Ser Phe His Ser Ile Lys Gln Thr Ala Ala Val 
385                 390                 395         


<210>  3519
<211>  438
<212>  PRT
<213>  Homo Sapiens

<400>  3519

Met Arg Gly Pro Ser Gly Pro Pro Gly Leu Leu Tyr Val Pro His Leu 
1               5                   10                  15      


Leu Leu Cys Leu Leu Cys Leu Leu Pro Pro Pro Leu Gln Tyr Ala Ala 
            20                  25                  30          


Gly Gln Ser Gln Met Pro Lys Asp Gln Pro Leu Trp Ala Leu Leu Glu 
        35                  40                  45              


Gln Tyr Cys His Thr Ile Met Thr Leu Thr Asn Leu Ser Gly Pro Tyr 
    50                  55                  60                  


Ser Tyr Cys Asn Thr Thr Leu Asp Gln Ile Gly Thr Cys Trp Pro Arg 
65                  70                  75                  80  


Ser Ala Ala Gly Ala Leu Val Glu Arg Pro Cys Pro Glu Tyr Phe Asn 
                85                  90                  95      


Gly Val Lys Tyr Asn Thr Thr Arg Asn Ala Tyr Arg Glu Cys Leu Glu 
            100                 105                 110         


Asn Gly Thr Trp Ala Ser Lys Ile Asn Tyr Ser Gln Cys Glu Pro Ile 
        115                 120                 125             


Leu Asp Asp Lys Gln Arg Lys Tyr Asp Leu His Tyr Arg Ile Ala Leu 
    130                 135                 140                 


Val Val Asn Tyr Leu Gly His Cys Val Ser Val Ala Ala Leu Val Ala 
145                 150                 155                 160 


Ala Phe Leu Leu Phe Leu Ala Leu Arg Ser Ile Arg Cys Leu Arg Asn 
                165                 170                 175     


Val Ile His Trp Asn Leu Ile Thr Thr Phe Ile Leu Arg Asn Val Met 
            180                 185                 190         


Trp Phe Leu Leu Gln Leu Val Asp His Glu Val His Glu Ser Asn Glu 
        195                 200                 205             


Val Trp Cys Arg Cys Ile Thr Thr Ile Phe Asn Tyr Phe Val Val Thr 
    210                 215                 220                 


Asn Phe Phe Trp Met Phe Val Glu Gly Cys Tyr Leu His Thr Ala Ile 
225                 230                 235                 240 


Val Met Thr Tyr Ser Thr Glu Arg Leu Arg Lys Cys Leu Phe Leu Phe 
                245                 250                 255     


Ile Gly Trp Cys Ile Pro Phe Pro Ile Ile Val Ala Trp Ala Ile Gly 
            260                 265                 270         


Lys Leu Tyr Tyr Glu Asn Glu Gln Cys Trp Phe Gly Lys Glu Pro Gly 
        275                 280                 285             


Asp Leu Val Asp Tyr Ile Tyr Gln Gly Pro Ile Ile Leu Val Leu Leu 
    290                 295                 300                 


Ile Asn Phe Val Phe Leu Phe Asn Ile Val Arg Ile Leu Met Thr Lys 
305                 310                 315                 320 


Leu Arg Ala Ser Thr Thr Ser Glu Thr Ile Gln Tyr Arg Lys Ala Val 
                325                 330                 335     


Lys Ala Thr Leu Val Leu Leu Pro Leu Leu Gly Ile Thr Tyr Met Leu 
            340                 345                 350         


Phe Phe Val Asn Pro Gly Glu Asp Asp Leu Ser Gln Ile Met Phe Ile 
        355                 360                 365             


Tyr Phe Asn Ser Phe Leu Gln Ser Phe Gln Gly Phe Phe Val Ser Val 
    370                 375                 380                 


Phe Tyr Cys Phe Phe Asn Gly Glu Val Arg Ser Ala Val Arg Lys Arg 
385                 390                 395                 400 


Trp His Arg Trp Gln Asp His His Ser Leu Arg Val Pro Met Ala Arg 
                405                 410                 415     


Ala Met Ser Ile Pro Thr Ser Pro Thr Arg Ile Ser Phe His Ser Ile 
            420                 425                 430         


Lys Gln Thr Ala Ala Val 
        435             


<210>  3520
<211>  64
<212>  PRT
<213>  Homo Sapiens

<400>  3520

Met Arg Gly Pro Ser Gly Pro Pro Gly Leu Leu Tyr Val Pro His Leu 
1               5                   10                  15      


Leu Leu Cys Leu Leu Cys Leu Leu Pro Pro Pro Leu Gln Tyr Ala Ala 
            20                  25                  30          


Gly Gln Ser Gln Met Pro Lys Asp Gln Pro Leu Trp Ala Leu Leu Glu 
        35                  40                  45              


Gln Tyr Cys His Thr Ile Met Thr Leu Thr Asn Leu Ser Gly Trp Ser 
    50                  55                  60                  


<210>  3521
<211>  64
<212>  PRT
<213>  Homo Sapiens

<400>  3521

Met Arg Gly Pro Ser Gly Pro Pro Gly Leu Leu Tyr Val Pro His Leu 
1               5                   10                  15      


Leu Leu Cys Leu Leu Cys Leu Leu Pro Pro Pro Leu Gln Tyr Ala Ala 
            20                  25                  30          


Gly Gln Ser Gln Met Pro Lys Asp Gln Pro Leu Trp Ala Leu Leu Glu 
        35                  40                  45              


Gln Tyr Cys His Thr Ile Met Thr Leu Thr Asn Leu Ser Gly Trp Ser 
    50                  55                  60                  


<210>  3522
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  3522

Met Arg Gly Pro Ser Gly Pro Pro Gly Leu Leu Tyr Val Pro His Leu 
1               5                   10                  15      


Leu Leu Cys Leu Leu Cys Leu Leu Pro Pro Pro Leu Gln Tyr Ala Ala 
            20                  25                  30          


Gly Gln Ser Gln Met Pro Lys Asp Gln Pro Leu Trp Ala Leu Leu Glu 
        35                  40                  45              


Gln Tyr Cys His Thr Ile Met Thr Leu Thr Asn Leu Ser Val Thr Pro 
    50                  55                  60                  


Gly Ala His Ser His Ser Leu Ser Ala Arg Gly Cys Gly Thr Arg Trp 
65                  70                  75                  80  


Thr Arg His Cys Ser Thr Ala Cys Trp Arg Pro Thr Ala Ala Trp Arg 
                85                  90                  95      


Trp Leu Lys 
            


<210>  3523
<211>  178
<212>  PRT
<213>  Homo Sapiens

<400>  3523

Met Glu Ile Lys His Leu Leu Phe Leu Val Ala Ala Ala Cys Leu Leu 
1               5                   10                  15      


Pro Met Leu Ser Met Lys Lys Lys Ser Ala Arg Asp Gln Phe Asn Lys 
            20                  25                  30          


Leu Val Thr Asp Leu Pro Asn Val Gln Glu Glu Ile Val Asn Ile His 
        35                  40                  45              


Asn Ala Leu Arg Arg Arg Val Val Pro Pro Ala Ser Asn Met Leu Lys 
    50                  55                  60                  


Met Ser Trp Ser Glu Glu Ala Ala Gln Asn Ala Arg Ile Phe Ser Lys 
65                  70                  75                  80  


Tyr Cys Asp Met Thr Glu Ser Asn Pro Leu Glu Arg Arg Leu Pro Asn 
                85                  90                  95      


Thr Phe Cys Gly Glu Asn Met His Met Thr Ser Tyr Pro Val Ser Trp 
            100                 105                 110         


Ser Ser Val Ile Gly Val Trp Tyr Ser Glu Ser Thr Ser Phe Lys His 
        115                 120                 125             


Gly Glu Trp Thr Thr Thr Asp Asp Asp Ile Thr Thr Asp His Tyr Thr 
    130                 135                 140                 


Gln Ile Val Trp Ala Thr Ser Tyr Leu Ile Gly Cys Ala Ile Ala Ser 
145                 150                 155                 160 


Cys Arg Gln Gln Gly Ser Pro Arg Tyr Leu Tyr Val Cys His Tyr Cys 
                165                 170                 175     


His Asp 
        


<210>  3524
<211>  178
<212>  PRT
<213>  Homo Sapiens

<400>  3524

Met Glu Ile Lys His Leu Leu Phe Leu Val Ala Ala Ala Cys Leu Leu 
1               5                   10                  15      


Pro Met Leu Ser Met Lys Lys Lys Ser Ala Arg Asp Gln Phe Asn Lys 
            20                  25                  30          


Leu Val Thr Asp Leu Pro Asn Val Gln Glu Glu Ile Val Asn Ile His 
        35                  40                  45              


Asn Ala Leu Arg Arg Arg Val Val Pro Pro Ala Ser Asn Met Leu Lys 
    50                  55                  60                  


Met Ser Trp Ser Glu Glu Ala Ala Gln Asn Ala Arg Ile Phe Ser Lys 
65                  70                  75                  80  


Tyr Cys Asp Met Thr Glu Ser Asn Pro Leu Glu Arg Arg Leu Pro Asn 
                85                  90                  95      


Thr Phe Cys Gly Glu Asn Met His Met Thr Ser Tyr Pro Val Ser Trp 
            100                 105                 110         


Ser Ser Val Ile Gly Val Trp Tyr Ser Glu Ser Thr Ser Phe Lys His 
        115                 120                 125             


Gly Glu Trp Thr Thr Thr Asp Asp Asp Ile Thr Thr Asp His Tyr Thr 
    130                 135                 140                 


Gln Ile Val Trp Ala Thr Ser Tyr Leu Ile Gly Cys Ala Ile Ala Ser 
145                 150                 155                 160 


Cys Arg Gln Gln Gly Ser Pro Arg Tyr Leu Tyr Val Cys His Tyr Cys 
                165                 170                 175     


His Asp 
        


<210>  3525
<211>  249
<212>  PRT
<213>  Homo Sapiens

<400>  3525

Met Glu Ile Lys His Leu Leu Phe Leu Val Ala Ala Ala Cys Leu Leu 
1               5                   10                  15      


Pro Met Leu Ser Met Lys Lys Lys Ser Ala Arg Asp Gln Phe Asn Lys 
            20                  25                  30          


Leu Val Thr Asp Leu Pro Asn Val Gln Glu Glu Ile Val Asn Ile His 
        35                  40                  45              


Asn Ala Leu Arg Arg Arg Val Val Pro Pro Ala Ser Asn Met Leu Lys 
    50                  55                  60                  


Met Ser Trp Ser Glu Glu Ala Ala Gln Asn Ala Arg Ile Phe Ser Lys 
65                  70                  75                  80  


Tyr Cys Asp Met Thr Glu Ser Asn Pro Leu Glu Arg Arg Leu Pro Asn 
                85                  90                  95      


Thr Phe Cys Gly Glu Asn Met His Met Thr Ser Tyr Pro Val Ser Trp 
            100                 105                 110         


Ser Ser Val Ile Gly Val Trp Tyr Ser Glu Ser Thr Ser Phe Lys His 
        115                 120                 125             


Gly Glu Trp Thr Thr Thr Asp Asp Asp Ile Thr Thr Asp His Tyr Thr 
    130                 135                 140                 


Gln Ile Val Trp Ala Thr Ser Tyr Leu Ile Gly Cys Ala Ile Ala Ser 
145                 150                 155                 160 


Cys Arg Gln Gln Gly Ser Pro Arg Tyr Leu Tyr Val Cys His Tyr Cys 
                165                 170                 175     


His Glu Gly Asn Asp Pro Glu Thr Lys Asn Glu Pro Tyr Lys Thr Gly 
            180                 185                 190         


Val Pro Cys Glu Ala Cys Pro Ser Asn Cys Glu Asp Lys Leu Cys Thr 
        195                 200                 205             


Asn Pro Cys Ile Tyr Tyr Asp Glu Tyr Phe Asp Cys Asp Ile Gln Val 
    210                 215                 220                 


His Tyr Leu Gly Cys Asn His Ser Thr Thr Ile Leu Phe Cys Lys Ala 
225                 230                 235                 240 


Thr Cys Leu Cys Asp Thr Glu Ile Lys 
                245                 


<210>  3526
<211>  249
<212>  PRT
<213>  Homo Sapiens

<400>  3526

Met Glu Ile Lys His Leu Leu Phe Leu Val Ala Ala Ala Cys Leu Leu 
1               5                   10                  15      


Pro Met Leu Ser Met Lys Lys Lys Ser Ala Arg Asp Gln Phe Asn Lys 
            20                  25                  30          


Leu Val Thr Asp Leu Pro Asn Val Gln Glu Glu Ile Val Asn Ile His 
        35                  40                  45              


Asn Ala Leu Arg Arg Arg Val Val Pro Pro Ala Ser Asn Met Leu Lys 
    50                  55                  60                  


Met Ser Trp Ser Glu Glu Ala Ala Gln Asn Ala Arg Ile Phe Ser Lys 
65                  70                  75                  80  


Tyr Cys Asp Met Thr Glu Ser Asn Pro Leu Glu Arg Arg Leu Pro Asn 
                85                  90                  95      


Thr Phe Cys Gly Glu Asn Met His Met Thr Ser Tyr Pro Val Ser Trp 
            100                 105                 110         


Ser Ser Val Ile Gly Val Trp Tyr Ser Glu Ser Thr Ser Phe Lys His 
        115                 120                 125             


Gly Glu Trp Thr Thr Thr Asp Asp Asp Ile Thr Thr Asp His Tyr Thr 
    130                 135                 140                 


Gln Ile Val Trp Ala Thr Ser Tyr Leu Ile Gly Cys Ala Ile Ala Ser 
145                 150                 155                 160 


Cys Arg Gln Gln Gly Ser Pro Arg Tyr Leu Tyr Val Cys His Tyr Cys 
                165                 170                 175     


His Glu Gly Asn Asp Pro Glu Thr Lys Asn Glu Pro Tyr Lys Thr Gly 
            180                 185                 190         


Val Pro Cys Glu Ala Cys Pro Ser Asn Cys Glu Asp Lys Leu Cys Thr 
        195                 200                 205             


Asn Pro Cys Ile Tyr Tyr Asp Glu Tyr Phe Asp Cys Asp Ile Gln Val 
    210                 215                 220                 


His Tyr Leu Gly Cys Asn His Ser Thr Thr Ile Leu Phe Cys Lys Ala 
225                 230                 235                 240 


Thr Cys Leu Cys Asp Thr Glu Ile Lys 
                245                 


<210>  3527
<211>  243
<212>  PRT
<213>  Homo Sapiens

<400>  3527

Met Ala Leu Leu Pro Val Leu Phe Leu Val Thr Val Leu Leu Pro Ser 
1               5                   10                  15      


Leu Pro Ala Glu Gly Lys Asp Pro Ala Phe Thr Ala Leu Leu Thr Thr 
            20                  25                  30          


Gln Leu Gln Val Gln Arg Glu Ile Val Asn Lys His Asn Glu Leu Arg 
        35                  40                  45              


Lys Ala Val Ser Pro Pro Ala Ser Asn Met Leu Lys Met Glu Trp Ser 
    50                  55                  60                  


Arg Glu Val Thr Thr Asn Ala Gln Arg Trp Ala Asn Lys Cys Thr Leu 
65                  70                  75                  80  


Gln His Ser Asp Pro Glu Asp Arg Lys Thr Ser Thr Arg Cys Gly Glu 
                85                  90                  95      


Asn Leu Tyr Met Ser Ser Asp Pro Thr Ser Trp Ser Ser Ala Ile Gln 
            100                 105                 110         


Ser Trp Tyr Asp Glu Ile Leu Asp Phe Val Tyr Gly Val Gly Pro Lys 
        115                 120                 125             


Ser Pro Asn Ala Val Val Gly His Tyr Thr Gln Leu Val Trp Tyr Ser 
    130                 135                 140                 


Thr Tyr Gln Val Gly Cys Gly Ile Ala Tyr Cys Pro Asn Gln Asp Ser 
145                 150                 155                 160 


Leu Lys Tyr Tyr Tyr Val Cys Gln Tyr Cys Pro Ala Gly Asn Asn Met 
                165                 170                 175     


Asn Arg Lys Asn Thr Pro Tyr Gln Gln Gly Thr Pro Cys Ala Gly Cys 
            180                 185                 190         


Pro Asp Asp Cys Asp Lys Gly Leu Cys Thr Asn Ser Cys Gln Tyr Gln 
        195                 200                 205             


Asp Leu Leu Ser Asn Cys Asp Ser Leu Lys Asn Thr Ala Gly Cys Glu 
    210                 215                 220                 


His Glu Leu Leu Lys Glu Lys Cys Lys Ala Thr Cys Leu Cys Glu Asn 
225                 230                 235                 240 


Lys Ile Tyr 
            


<210>  3528
<211>  243
<212>  PRT
<213>  Homo Sapiens

<400>  3528

Met Ala Leu Leu Pro Val Leu Phe Leu Val Thr Val Leu Leu Pro Ser 
1               5                   10                  15      


Leu Pro Ala Glu Gly Lys Asp Pro Ala Phe Thr Ala Leu Leu Thr Thr 
            20                  25                  30          


Gln Leu Gln Val Gln Arg Glu Ile Val Asn Lys His Asn Glu Leu Arg 
        35                  40                  45              


Lys Ala Val Ser Pro Pro Ala Ser Asn Met Leu Lys Met Glu Trp Ser 
    50                  55                  60                  


Arg Glu Val Thr Thr Asn Ala Gln Arg Trp Ala Asn Lys Cys Thr Leu 
65                  70                  75                  80  


Gln His Ser Asp Pro Glu Asp Arg Lys Thr Ser Thr Arg Cys Gly Glu 
                85                  90                  95      


Asn Leu Tyr Met Ser Ser Asp Pro Thr Ser Trp Ser Ser Ala Ile Gln 
            100                 105                 110         


Ser Trp Tyr Asp Glu Ile Leu Asp Phe Val Tyr Gly Val Gly Pro Lys 
        115                 120                 125             


Ser Pro Asn Ala Val Val Gly His Tyr Thr Gln Leu Val Trp Tyr Ser 
    130                 135                 140                 


Thr Tyr Gln Val Gly Cys Gly Ile Ala Tyr Cys Pro Asn Gln Asp Ser 
145                 150                 155                 160 


Leu Lys Tyr Tyr Tyr Val Cys Gln Tyr Cys Pro Ala Gly Asn Asn Met 
                165                 170                 175     


Asn Arg Lys Asn Thr Pro Tyr Gln Gln Gly Thr Pro Cys Ala Gly Cys 
            180                 185                 190         


Pro Asp Asp Cys Asp Lys Gly Leu Cys Thr Asn Ser Cys Gln Tyr Gln 
        195                 200                 205             


Asp Leu Leu Ser Asn Cys Asp Ser Leu Lys Asn Thr Ala Gly Cys Glu 
    210                 215                 220                 


His Glu Leu Leu Lys Glu Lys Cys Lys Ala Thr Cys Leu Cys Glu Asn 
225                 230                 235                 240 


Lys Ile Tyr 
            


<210>  3529
<211>  278
<212>  PRT
<213>  Homo Sapiens

<400>  3529

Met Ala Leu Leu Pro Val Leu Phe Leu Val Thr Val Leu Leu Pro Ser 
1               5                   10                  15      


Leu Pro Ala Glu Gly Lys Asp Pro Ala Phe Thr Ala Leu Leu Thr Thr 
            20                  25                  30          


Gln Leu Gln Val Gln Arg Glu Ile Val Asn Lys His Asn Glu Leu Arg 
        35                  40                  45              


Lys Ala Val Ser Pro Pro Ala Ser Asn Met Leu Lys Met Glu Trp Ser 
    50                  55                  60                  


Arg Glu Val Thr Thr Asn Ala Gln Arg Trp Ala Asn Lys Cys Thr Leu 
65                  70                  75                  80  


Gln His Ser Asp Pro Glu Asp Arg Lys Thr Ser Thr Arg Cys Gly Glu 
                85                  90                  95      


Asn Leu Tyr Met Ser Ser Asp Pro Thr Ser Trp Ser Ser Ala Ile Gln 
            100                 105                 110         


Ser Trp Tyr Asp Glu Ile Leu Asp Phe Val Tyr Gly Val Gly Pro Lys 
        115                 120                 125             


Ser Pro Asn Ala Val Val Gly His Tyr Thr Gln Leu Val Trp Tyr Ser 
    130                 135                 140                 


Thr Tyr Gln Val Gly Cys Gly Ile Ala Tyr Cys Pro Asn Gln Asp Ser 
145                 150                 155                 160 


Leu Lys Tyr Tyr Tyr Val Cys Gln Tyr Cys Pro Ala Met Lys Thr Tyr 
                165                 170                 175     


Leu Asn Lys Arg Glu Gly Ile Asn Val Trp Lys Cys Phe Leu Arg Leu 
            180                 185                 190         


Arg His Phe Gln Leu Leu Arg Gly Glu Gln Leu Leu Thr Phe Ser Gly 
        195                 200                 205             


Asn Asn Met Asn Arg Lys Asn Thr Pro Tyr Gln Gln Gly Thr Pro Cys 
    210                 215                 220                 


Ala Gly Cys Pro Asp Asp Cys Asp Lys Gly Leu Cys Thr Asn Ser Cys 
225                 230                 235                 240 


Gln Tyr Gln Asp Leu Leu Ser Asn Cys Asp Ser Leu Lys Asn Thr Ala 
                245                 250                 255     


Gly Cys Glu His Glu Leu Leu Lys Glu Lys Cys Lys Ala Thr Cys Leu 
            260                 265                 270         


Cys Glu Asn Lys Ile Tyr 
        275             


<210>  3530
<211>  276
<212>  PRT
<213>  Homo Sapiens

<400>  3530

Met Lys Gln Ile Leu His Pro Ala Leu Glu Thr Thr Ala Cys Thr Asn 
1               5                   10                  15      


His Phe Asn Ala Asp Pro Cys Ser Thr Gly Phe Val Phe Pro Ala Met 
            20                  25                  30          


Thr Leu Phe Pro Val Leu Leu Phe Leu Val Ala Gly Leu Leu Pro Ser 
        35                  40                  45              


Phe Pro Ala Asn Glu Asp Lys Asp Pro Ala Phe Thr Ala Leu Leu Thr 
    50                  55                  60                  


Thr Gln Thr Gln Val Gln Arg Glu Ile Val Asn Lys His Asn Glu Leu 
65                  70                  75                  80  


Arg Arg Ala Val Ser Pro Pro Ala Arg Asn Met Leu Lys Met Glu Trp 
                85                  90                  95      


Asn Lys Glu Ala Ala Ala Asn Ala Gln Lys Trp Ala Asn Gln Cys Asn 
            100                 105                 110         


Tyr Arg His Ser Asn Pro Lys Asp Arg Met Thr Ser Leu Lys Cys Gly 
        115                 120                 125             


Glu Asn Leu Tyr Met Ser Ser Ala Ser Ser Ser Trp Ser Gln Ala Ile 
    130                 135                 140                 


Gln Ser Trp Phe Asp Glu Tyr Asn Asp Phe Asp Phe Gly Val Gly Pro 
145                 150                 155                 160 


Lys Thr Pro Asn Ala Val Val Gly His Tyr Thr Gln Val Val Trp Tyr 
                165                 170                 175     


Ser Ser Tyr Leu Val Gly Cys Gly Asn Ala Tyr Cys Pro Asn Gln Lys 
            180                 185                 190         


Val Leu Lys Tyr Tyr Tyr Val Cys Gln Tyr Cys Pro Ala Gly Asn Trp 
        195                 200                 205             


Ala Asn Arg Leu Tyr Val Pro Tyr Glu Gln Gly Ala Pro Cys Ala Ser 
    210                 215                 220                 


Cys Pro Asp Asn Cys Asp Asp Gly Leu Cys Thr Asn Gly Cys Lys Tyr 
225                 230                 235                 240 


Glu Asp Leu Tyr Ser Asn Cys Lys Ser Leu Lys Leu Thr Leu Thr Cys 
                245                 250                 255     


Lys His Gln Leu Val Arg Asp Ser Cys Lys Ala Ser Cys Asn Cys Ser 
            260                 265                 270         


Asn Ser Ile Tyr 
        275     


<210>  3531
<211>  258
<212>  PRT
<213>  Homo Sapiens

<400>  3531

Met Lys Gln Ile Leu His Pro Ala Leu Glu Thr Thr Ala Met Thr Leu 
1               5                   10                  15      


Phe Pro Val Leu Leu Phe Leu Val Ala Gly Leu Leu Pro Ser Phe Pro 
            20                  25                  30          


Ala Asn Glu Asp Lys Asp Pro Ala Phe Thr Ala Leu Leu Thr Thr Gln 
        35                  40                  45              


Thr Gln Val Gln Arg Glu Ile Val Asn Lys His Asn Glu Leu Arg Arg 
    50                  55                  60                  


Ala Val Ser Pro Pro Ala Arg Asn Met Leu Lys Met Glu Trp Asn Lys 
65                  70                  75                  80  


Glu Ala Ala Ala Asn Ala Gln Lys Trp Ala Asn Gln Cys Asn Tyr Arg 
                85                  90                  95      


His Ser Asn Pro Lys Asp Arg Met Thr Ser Leu Lys Cys Gly Glu Asn 
            100                 105                 110         


Leu Tyr Met Ser Ser Ala Ser Ser Ser Trp Ser Gln Ala Ile Gln Ser 
        115                 120                 125             


Trp Phe Asp Glu Tyr Asn Asp Phe Asp Phe Gly Val Gly Pro Lys Thr 
    130                 135                 140                 


Pro Asn Ala Val Val Gly His Tyr Thr Gln Val Val Trp Tyr Ser Ser 
145                 150                 155                 160 


Tyr Leu Val Gly Cys Gly Asn Ala Tyr Cys Pro Asn Gln Lys Val Leu 
                165                 170                 175     


Lys Tyr Tyr Tyr Val Cys Gln Tyr Cys Pro Ala Gly Asn Trp Ala Asn 
            180                 185                 190         


Arg Leu Tyr Val Pro Tyr Glu Gln Gly Ala Pro Cys Ala Ser Cys Pro 
        195                 200                 205             


Asp Asn Cys Asp Asp Gly Leu Cys Thr Asn Gly Cys Lys Tyr Glu Asp 
    210                 215                 220                 


Leu Tyr Ser Asn Cys Lys Ser Leu Lys Leu Thr Leu Thr Cys Lys His 
225                 230                 235                 240 


Gln Leu Val Arg Asp Ser Cys Lys Ala Ser Cys Asn Cys Ser Asn Ser 
                245                 250                 255     


Ile Tyr 
        


<210>  3532
<211>  191
<212>  PRT
<213>  Homo Sapiens

<400>  3532

Met Lys Gln Ile Leu His Pro Ala Leu Glu Thr Thr Asp Pro Cys Ser 
1               5                   10                  15      


Thr Gly Phe Val Phe Pro Ala Met Thr Leu Phe Pro Val Leu Leu Phe 
            20                  25                  30          


Leu Val Ala Gly Leu Leu Pro Ser Phe Pro Ala Asn Glu Asp Lys Asp 
        35                  40                  45              


Pro Ala Phe Thr Ala Leu Leu Thr Thr Gln Thr Gln Val Gln Arg Glu 
    50                  55                  60                  


Ile Val Asn Lys His Asn Glu Leu Arg Arg Ala Val Ser Pro Pro Ala 
65                  70                  75                  80  


Arg Asn Met Leu Lys Met Glu Trp Asn Lys Glu Ala Ala Ala Asn Ala 
                85                  90                  95      


Gln Lys Trp Ala Asn Gln Cys Asn Tyr Arg His Ser Asn Pro Lys Asp 
            100                 105                 110         


Arg Met Thr Ser Leu Lys Cys Gly Glu Asn Leu Tyr Met Ser Ser Ala 
        115                 120                 125             


Ser Ser Ser Trp Ser Gln Ala Ile Gln Ser Trp Phe Asp Glu Tyr Asn 
    130                 135                 140                 


Asp Phe Asp Phe Gly Val Gly Pro Lys Thr Pro Asn Ala Val Val Gly 
145                 150                 155                 160 


His Tyr Thr Gln Val Val Trp Tyr Ser Ser Tyr Leu Val Gly Cys Gly 
                165                 170                 175     


Asn Ala Tyr Cys Pro Asn Gln Lys Val Leu Lys Tyr Tyr Tyr Val 
            180                 185                 190     


<210>  3533
<211>  268
<212>  PRT
<213>  Homo Sapiens

<400>  3533

Met Lys Gln Ile Leu His Pro Ala Leu Glu Thr Thr Asp Pro Cys Ser 
1               5                   10                  15      


Thr Gly Phe Val Phe Pro Ala Met Thr Leu Phe Pro Val Leu Leu Phe 
            20                  25                  30          


Leu Val Ala Gly Leu Leu Pro Ser Phe Pro Ala Asn Glu Asp Lys Asp 
        35                  40                  45              


Pro Ala Phe Thr Ala Leu Leu Thr Thr Gln Thr Gln Val Gln Arg Glu 
    50                  55                  60                  


Ile Val Asn Lys His Asn Glu Leu Arg Arg Ala Val Ser Pro Pro Ala 
65                  70                  75                  80  


Arg Asn Met Leu Lys Met Glu Trp Asn Lys Glu Ala Ala Ala Asn Ala 
                85                  90                  95      


Gln Lys Trp Ala Asn Gln Cys Asn Tyr Arg His Ser Asn Pro Lys Asp 
            100                 105                 110         


Arg Met Thr Ser Leu Lys Cys Gly Glu Asn Leu Tyr Met Ser Ser Ala 
        115                 120                 125             


Ser Ser Ser Trp Ser Gln Ala Ile Gln Ser Trp Phe Asp Glu Tyr Asn 
    130                 135                 140                 


Asp Phe Asp Phe Gly Val Gly Pro Lys Thr Pro Asn Ala Val Val Gly 
145                 150                 155                 160 


His Tyr Thr Gln Val Val Trp Tyr Ser Ser Tyr Leu Val Gly Cys Gly 
                165                 170                 175     


Asn Ala Tyr Cys Pro Asn Gln Lys Val Leu Lys Tyr Tyr Tyr Val Cys 
            180                 185                 190         


Gln Tyr Cys Pro Ala Gly Asn Trp Ala Asn Arg Leu Tyr Val Pro Tyr 
        195                 200                 205             


Glu Gln Gly Ala Pro Cys Ala Ser Cys Pro Asp Asn Cys Asp Asp Gly 
    210                 215                 220                 


Leu Cys Thr Asn Gly Cys Lys Tyr Glu Asp Leu Tyr Ser Asn Cys Lys 
225                 230                 235                 240 


Ser Leu Lys Leu Thr Leu Thr Cys Lys His Gln Leu Val Arg Asp Ser 
                245                 250                 255     


Cys Lys Ala Ser Cys Asn Cys Ser Asn Ser Ile Tyr 
            260                 265             


<210>  3534
<211>  112
<212>  PRT
<213>  Homo Sapiens

<400>  3534

Met Cys Thr His Tyr Thr Gln Ile Val Trp Ala Thr Thr Asn Lys Ile 
1               5                   10                  15      


Gly Cys Ala Val Asn Thr Cys Arg Lys Met Thr Val Trp Gly Glu Val 
            20                  25                  30          


Trp Glu Asn Ala Val Tyr Phe Val Cys Asn Tyr Ser Pro Lys Gly Asn 
        35                  40                  45              


Trp Ile Gly Glu Ala Pro Tyr Lys Asn Gly Arg Pro Cys Ser Glu Cys 
    50                  55                  60                  


Pro Pro Ser Tyr Gly Gly Ser Cys Arg Asn Asn Leu Cys Tyr Arg Glu 
65                  70                  75                  80  


Glu Thr Tyr Thr Pro Lys Pro Glu Thr Asp Glu Met Asn Glu Val Glu 
                85                  90                  95      


Thr Ala Pro Ile Pro Glu Glu Asn His Val Trp Leu Gln Pro Arg Val 
            100                 105                 110         


<210>  3535
<211>  210
<212>  PRT
<213>  Homo Sapiens

<400>  3535

Met Cys Thr His Tyr Thr Gln Ile Val Trp Ala Thr Thr Asn Lys Ile 
1               5                   10                  15      


Gly Cys Ala Val Asn Thr Cys Arg Lys Met Thr Val Trp Gly Glu Val 
            20                  25                  30          


Trp Glu Asn Ala Val Tyr Phe Val Cys Asn Tyr Ser Pro Lys Gly Asn 
        35                  40                  45              


Trp Ile Gly Glu Ala Pro Tyr Lys Asn Gly Arg Pro Cys Ser Glu Cys 
    50                  55                  60                  


Pro Pro Ser Tyr Gly Gly Ser Cys Arg Asn Asn Leu Cys Tyr Arg Glu 
65                  70                  75                  80  


Glu Thr Tyr Thr Pro Lys Pro Glu Thr Asp Glu Met Asn Glu Val Glu 
                85                  90                  95      


Thr Ala Pro Ile Pro Glu Glu Asn His Val Trp Leu Gln Pro Arg Val 
            100                 105                 110         


Met Arg Pro Thr Lys Pro Lys Lys Thr Ser Ala Val Asn Tyr Met Thr 
        115                 120                 125             


Gln Val Val Arg Cys Asp Thr Lys Met Lys Asp Arg Cys Lys Gly Ser 
    130                 135                 140                 


Thr Cys Asn Arg Tyr Gln Cys Pro Ala Gly Cys Leu Asn His Lys Ala 
145                 150                 155                 160 


Lys Ile Phe Gly Thr Leu Phe Tyr Glu Ser Ser Ser Ser Ile Cys Arg 
                165                 170                 175     


Ala Ala Ile His Tyr Gly Ile Leu Asp Asp Lys Gly Gly Leu Val Asp 
            180                 185                 190         


Ile Thr Arg Asn Gly Lys Val Pro Phe Phe Val Lys Ser Glu Arg His 
        195                 200                 205             


Gly Val 
    210 


<210>  3536
<211>  19
<212>  PRT
<213>  Homo Sapiens

<400>  3536

Met Ser Cys Val Leu Gly Gly Val Ile Pro Leu Gly Leu Leu Phe Leu 
1               5                   10                  15      


Val Cys Gly 
            


<210>  3537
<211>  120
<212>  PRT
<213>  Homo Sapiens

<400>  3537

Met Ser Cys Val Leu Gly Gly Val Ile Pro Leu Gly Leu Leu Phe Leu 
1               5                   10                  15      


Val Cys Gly Ser Gln Gly Tyr Leu Leu Pro Asn Val Thr Leu Leu Glu 
            20                  25                  30          


Glu Leu Leu Ser Lys Tyr Gln His Asn Glu Ser His Ser Arg Val Arg 
        35                  40                  45              


Arg Ala Ile Pro Arg Glu Asp Lys Glu Glu Ile Leu Met Leu His Asn 
    50                  55                  60                  


Lys Leu Arg Gly Gln Val Gln Pro Gln Ala Ser Asn Met Glu Tyr Met 
65                  70                  75                  80  


Thr Trp Asp Asp Glu Leu Glu Lys Ser Ala Ala Ala Trp Ala Ser Gln 
                85                  90                  95      


Cys Ile Trp Glu His Gly Pro Thr Ser Leu Leu Val Ser Ile Gly Gln 
            100                 105                 110         


Asn Leu Gly Ala His Trp Gly Arg 
        115                 120 


<210>  3538
<211>  497
<212>  PRT
<213>  Homo Sapiens

<400>  3538

Met Ser Cys Val Leu Gly Gly Val Ile Pro Leu Gly Leu Leu Phe Leu 
1               5                   10                  15      


Val Cys Gly Ser Gln Gly Tyr Leu Leu Pro Asn Val Thr Leu Leu Glu 
            20                  25                  30          


Glu Leu Leu Ser Lys Tyr Gln His Asn Glu Ser His Ser Arg Val Arg 
        35                  40                  45              


Arg Ala Ile Pro Arg Glu Asp Lys Glu Glu Ile Leu Met Leu His Asn 
    50                  55                  60                  


Lys Leu Arg Gly Gln Val Gln Pro Gln Ala Ser Asn Met Glu Tyr Met 
65                  70                  75                  80  


Thr Trp Asp Asp Glu Leu Glu Lys Ser Ala Ala Ala Trp Ala Ser Gln 
                85                  90                  95      


Cys Ile Trp Glu His Gly Pro Thr Ser Leu Leu Val Ser Ile Gly Gln 
            100                 105                 110         


Asn Leu Gly Ala His Trp Gly Arg Tyr Arg Ser Pro Gly Phe His Val 
        115                 120                 125             


Gln Ser Trp Tyr Asp Glu Val Lys Asp Tyr Thr Tyr Pro Tyr Pro Ser 
    130                 135                 140                 


Glu Cys Asn Pro Trp Cys Pro Glu Arg Cys Ser Gly Pro Met Cys Thr 
145                 150                 155                 160 


His Tyr Thr Gln Ile Val Trp Ala Thr Thr Asn Lys Ile Gly Cys Ala 
                165                 170                 175     


Val Asn Thr Cys Arg Lys Met Thr Val Trp Gly Glu Val Trp Glu Asn 
            180                 185                 190         


Ala Val Tyr Phe Val Cys Asn Tyr Ser Pro Lys Gly Asn Trp Ile Gly 
        195                 200                 205             


Glu Ala Pro Tyr Lys Asn Gly Arg Pro Cys Ser Glu Cys Pro Pro Ser 
    210                 215                 220                 


Tyr Gly Gly Ser Cys Arg Asn Asn Leu Cys Tyr Arg Glu Glu Thr Tyr 
225                 230                 235                 240 


Thr Pro Lys Pro Glu Thr Asp Glu Met Asn Glu Val Glu Thr Ala Pro 
                245                 250                 255     


Ile Pro Glu Glu Asn His Val Trp Leu Gln Pro Arg Val Met Arg Pro 
            260                 265                 270         


Thr Lys Pro Lys Lys Thr Ser Ala Val Asn Tyr Met Thr Gln Val Val 
        275                 280                 285             


Arg Cys Asp Thr Lys Met Lys Asp Arg Cys Lys Gly Ser Thr Cys Asn 
    290                 295                 300                 


Arg Tyr Gln Cys Pro Ala Gly Cys Leu Asn His Lys Ala Lys Ile Phe 
305                 310                 315                 320 


Gly Thr Leu Phe Tyr Glu Ser Ser Ser Ser Ile Cys Arg Ala Ala Ile 
                325                 330                 335     


His Tyr Gly Ile Leu Asp Asp Lys Gly Gly Leu Val Asp Ile Thr Arg 
            340                 345                 350         


Asn Gly Lys Val Pro Phe Phe Val Lys Ser Glu Arg His Gly Val Gln 
        355                 360                 365             


Ser Leu Ser Lys Tyr Lys Pro Ser Ser Ser Phe Met Val Ser Lys Val 
    370                 375                 380                 


Lys Val Gln Asp Leu Asp Cys Tyr Thr Thr Val Ala Gln Leu Cys Pro 
385                 390                 395                 400 


Phe Glu Lys Pro Ala Thr His Cys Pro Arg Ile His Cys Pro Ala His 
                405                 410                 415     


Cys Lys Asp Glu Pro Ser Tyr Trp Ala Pro Val Phe Gly Thr Asn Ile 
            420                 425                 430         


Tyr Ala Asp Thr Ser Ser Ile Cys Lys Thr Ala Val His Ala Gly Val 
        435                 440                 445             


Ile Ser Asn Glu Ser Gly Gly Asp Val Asp Val Met Pro Val Asp Lys 
    450                 455                 460                 


Lys Lys Thr Tyr Val Gly Ser Leu Arg Asn Gly Val Gln Ser Glu Ser 
465                 470                 475                 480 


Leu Gly Thr Pro Arg Asp Gly Lys Ala Phe Arg Ile Phe Ala Val Arg 
                485                 490                 495     


Gln 
    


<210>  3539
<211>  449
<212>  PRT
<213>  Homo Sapiens

<400>  3539

Met Ser Cys Val Leu Gly Gly Val Ile Pro Leu Gly Leu Leu Phe Leu 
1               5                   10                  15      


Val Cys Gly Ser Gln Gly Tyr Leu Leu Pro Asn Val Thr Leu Leu Glu 
            20                  25                  30          


Glu Leu Leu Ser Lys Tyr Gln His Asn Glu Ser His Ser Arg Val Arg 
        35                  40                  45              


Arg Ala Ile Pro Arg Glu Asp Lys Glu Glu Ile Leu Met Leu His Asn 
    50                  55                  60                  


Lys Leu Arg Gly Gln Val Gln Pro Gln Ala Ser Asn Met Glu Tyr Met 
65                  70                  75                  80  


Thr Trp Asp Asp Glu Leu Glu Lys Ser Ala Ala Ala Trp Ala Ser Gln 
                85                  90                  95      


Cys Ile Trp Glu His Gly Pro Thr Ser Leu Leu Val Ser Ile Gly Gln 
            100                 105                 110         


Asn Leu Gly Ala His Trp Gly Arg Tyr Arg Ser Pro Gly Phe His Val 
        115                 120                 125             


Gln Ser Trp Tyr Asp Glu Val Lys Asp Tyr Thr Tyr Pro Tyr Pro Ser 
    130                 135                 140                 


Glu Cys Asn Pro Trp Cys Pro Glu Arg Cys Ser Gly Pro Met Cys Thr 
145                 150                 155                 160 


His Tyr Thr Gln Ile Val Trp Ala Thr Thr Asn Lys Ile Gly Cys Ala 
                165                 170                 175     


Val Asn Thr Cys Arg Lys Met Thr Val Trp Gly Glu Val Trp Glu Asn 
            180                 185                 190         


Ala Val Tyr Phe Val Cys Asn Tyr Ser Pro Lys Gly Asn Trp Ile Gly 
        195                 200                 205             


Glu Ala Pro Tyr Lys Asn Gly Arg Pro Cys Ser Glu Cys Pro Pro Ser 
    210                 215                 220                 


Tyr Gly Gly Ser Cys Arg Asn Asn Leu Cys Tyr Arg Glu Glu Thr Tyr 
225                 230                 235                 240 


Thr Pro Lys Pro Glu Thr Asp Glu Met Asn Glu Val Glu Thr Ala Pro 
                245                 250                 255     


Ile Pro Glu Glu Asn His Val Trp Leu Gln Pro Arg Val Met Arg Pro 
            260                 265                 270         


Thr Lys Pro Lys Lys Thr Ser Ala Val Asn Tyr Met Thr Gln Val Val 
        275                 280                 285             


Arg Cys Asp Thr Lys Met Lys Asp Arg Cys Lys Gly Ser Thr Cys Asn 
    290                 295                 300                 


Arg Tyr Gln Cys Pro Ala Gly Cys Leu Asn His Lys Ala Lys Ile Phe 
305                 310                 315                 320 


Gly Thr Leu Phe Tyr Glu Ser Ser Ser Ser Ile Cys Arg Ala Ala Ile 
                325                 330                 335     


His Tyr Gly Ile Leu Asp Asp Lys Gly Gly Leu Val Asp Ile Thr Arg 
            340                 345                 350         


Asn Gly Lys Val Pro Phe Phe Val Lys Ser Glu Arg His Gly Val Gln 
        355                 360                 365             


Ser Leu Ser Lys Tyr Lys Pro Ser Ser Ser Phe Met Val Ser Lys Val 
    370                 375                 380                 


Lys Val Gln Asp Leu Asp Cys Tyr Thr Thr Val Ala Gln Leu Cys Pro 
385                 390                 395                 400 


Phe Glu Lys Pro Ala Thr His Cys Pro Arg Ile His Cys Pro Ala His 
                405                 410                 415     


Cys Lys Asp Glu Pro Ser Tyr Trp Ala Pro Val Phe Gly Thr Asn Ile 
            420                 425                 430         


Tyr Ala Asp Val Ser Arg Met His Phe Gln Gln Leu Ser Arg Lys Ala 
        435                 440                 445             


Cys 
    


<210>  3540
<211>  496
<212>  PRT
<213>  Homo Sapiens

<400>  3540

Met Ser Cys Val Leu Gly Gly Val Ile Pro Leu Gly Leu Leu Phe Leu 
1               5                   10                  15      


Val Cys Gly Ser Gln Gly Tyr Leu Leu Pro Asn Val Thr Leu Leu Glu 
            20                  25                  30          


Glu Leu Leu Ser Lys Tyr Gln His Asn Glu Ser His Ser Arg Val Arg 
        35                  40                  45              


Arg Ala Ile Pro Arg Glu Asp Lys Glu Glu Ile Leu Met Leu His Asn 
    50                  55                  60                  


Lys Leu Arg Gly Gln Val Gln Pro Gln Ala Ser Asn Met Glu Tyr Met 
65                  70                  75                  80  


Thr Trp Asp Asp Glu Leu Glu Lys Ser Ala Ala Ala Trp Ala Ser Gln 
                85                  90                  95      


Cys Ile Trp Glu His Gly Pro Thr Ser Leu Leu Val Ser Ile Gly Gln 
            100                 105                 110         


Asn Leu Gly Ala His Trp Gly Arg Tyr Arg Ser Pro Gly Phe His Val 
        115                 120                 125             


Gln Ser Trp Tyr Asp Glu Val Lys Asp Tyr Thr Tyr Pro Tyr Pro Ser 
    130                 135                 140                 


Glu Cys Asn Pro Trp Cys Pro Glu Arg Cys Ser Gly Pro Met Cys Thr 
145                 150                 155                 160 


His Tyr Thr Gln Ile Val Trp Ala Thr Thr Asn Lys Ile Gly Cys Ala 
                165                 170                 175     


Val Asn Thr Cys Arg Lys Met Thr Val Trp Gly Glu Val Trp Glu Asn 
            180                 185                 190         


Ala Val Tyr Phe Val Cys Asn Tyr Ser Pro Lys Gly Asn Trp Ile Gly 
        195                 200                 205             


Glu Ala Pro Tyr Lys Asn Gly Arg Pro Cys Ser Glu Cys Pro Pro Ser 
    210                 215                 220                 


Tyr Gly Gly Ser Cys Arg Asn Asn Leu Cys Tyr Arg Glu Thr Tyr Thr 
225                 230                 235                 240 


Pro Lys Pro Glu Thr Asp Glu Met Asn Glu Val Glu Thr Ala Pro Ile 
                245                 250                 255     


Pro Glu Glu Asn His Val Trp Leu Gln Pro Arg Val Met Arg Pro Thr 
            260                 265                 270         


Lys Pro Lys Lys Thr Ser Ala Val Asn Tyr Met Thr Gln Val Val Arg 
        275                 280                 285             


Cys Asp Thr Lys Met Lys Asp Arg Cys Lys Gly Ser Thr Cys Asn Arg 
    290                 295                 300                 


Tyr Gln Cys Pro Ala Gly Cys Leu Asn His Lys Ala Lys Ile Phe Gly 
305                 310                 315                 320 


Thr Leu Phe Tyr Glu Ser Ser Ser Ser Ile Cys Arg Ala Ala Ile His 
                325                 330                 335     


Tyr Gly Ile Leu Asp Asp Lys Gly Gly Leu Val Asp Ile Thr Arg Asn 
            340                 345                 350         


Gly Lys Val Pro Phe Phe Val Lys Ser Glu Arg His Gly Val Gln Ser 
        355                 360                 365             


Leu Ser Lys Tyr Lys Pro Ser Ser Ser Phe Met Val Ser Lys Val Lys 
    370                 375                 380                 


Val Gln Asp Leu Asp Cys Tyr Thr Thr Val Ala Gln Leu Cys Pro Phe 
385                 390                 395                 400 


Glu Lys Pro Ala Thr His Cys Pro Arg Ile His Cys Pro Ala His Cys 
                405                 410                 415     


Lys Asp Glu Pro Ser Tyr Trp Ala Pro Val Phe Gly Thr Asn Ile Tyr 
            420                 425                 430         


Ala Asp Thr Ser Ser Ile Cys Lys Thr Ala Val His Ala Gly Val Ile 
        435                 440                 445             


Ser Asn Glu Ser Gly Gly Asp Val Asp Val Met Pro Val Asp Lys Lys 
    450                 455                 460                 


Lys Thr Tyr Val Gly Ser Leu Arg Asn Gly Val Gln Ser Glu Ser Leu 
465                 470                 475                 480 


Gly Thr Pro Arg Asp Gly Lys Ala Phe Arg Ile Phe Ala Val Arg Gln 
                485                 490                 495     


<210>  3541
<211>  43
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3541

Xaa Lys Thr Ala Val His Ala Gly Val Ile Ser Asn Glu Ser Gly Gly 
1               5                   10                  15      


Asp Val Asp Val Met Pro Val Asp Lys Lys Lys Thr Tyr Val Gly Ser 
            20                  25                  30          


Leu Arg Asn Gly Val Gln Ser Glu Arg Asn Met 
        35                  40              


<210>  3542
<211>  422
<212>  PRT
<213>  Homo Sapiens

<400>  3542

Met Pro Ala Gly Arg Arg Gly Pro Ala Ala Gln Ser Ala Arg Arg Pro 
1               5                   10                  15      


Pro Pro Leu Leu Pro Leu Leu Leu Leu Leu Cys Val Leu Gly Ala Pro 
            20                  25                  30          


Arg Ala Gly Ser Gly Ala His Thr Ala Val Ile Ser Pro Gln Asp Pro 
        35                  40                  45              


Thr Leu Leu Ile Gly Ser Ser Leu Leu Ala Thr Cys Ser Val His Gly 
    50                  55                  60                  


Asp Pro Pro Gly Ala Thr Ala Glu Gly Leu Tyr Trp Thr Leu Asn Gly 
65                  70                  75                  80  


Arg Arg Leu Pro Pro Glu Leu Ser Arg Val Leu Asn Ala Ser Thr Leu 
                85                  90                  95      


Ala Leu Ala Leu Ala Asn Leu Asn Gly Ser Arg Gln Arg Ser Gly Asp 
            100                 105                 110         


Asn Leu Val Cys His Ala Arg Asp Gly Ser Ile Leu Ala Gly Ser Cys 
        115                 120                 125             


Leu Tyr Val Gly Leu Pro Pro Glu Lys Pro Val Asn Ile Ser Cys Trp 
    130                 135                 140                 


Ser Lys Asn Met Lys Asp Leu Thr Cys Arg Trp Thr Pro Gly Ala His 
145                 150                 155                 160 


Gly Glu Thr Phe Leu His Thr Asn Tyr Ser Leu Lys Tyr Lys Leu Arg 
                165                 170                 175     


Trp Tyr Gly Gln Asp Asn Thr Cys Glu Glu Tyr His Thr Val Gly Pro 
            180                 185                 190         


His Ser Cys His Ile Pro Lys Asp Leu Ala Leu Phe Thr Pro Tyr Glu 
        195                 200                 205             


Ile Trp Val Glu Ala Thr Asn Arg Leu Gly Ser Ala Arg Ser Asp Val 
    210                 215                 220                 


Leu Thr Leu Asp Ile Leu Asp Val Val Thr Thr Asp Pro Pro Pro Asp 
225                 230                 235                 240 


Val His Val Ser Arg Val Gly Gly Leu Glu Asp Gln Leu Ser Val Arg 
                245                 250                 255     


Trp Val Ser Pro Pro Ala Leu Lys Asp Phe Leu Phe Gln Ala Lys Tyr 
            260                 265                 270         


Gln Ile Arg Tyr Arg Val Glu Asp Ser Val Asp Trp Lys Val Val Asp 
        275                 280                 285             


Asp Val Ser Asn Gln Thr Ser Cys Arg Leu Ala Gly Leu Lys Pro Gly 
    290                 295                 300                 


Thr Val Tyr Phe Val Gln Val Arg Cys Asn Pro Phe Gly Ile Tyr Gly 
305                 310                 315                 320 


Ser Lys Lys Ala Gly Ile Trp Ser Glu Trp Ser His Pro Thr Ala Ala 
                325                 330                 335     


Ser Thr Pro Arg Ser Glu Arg Pro Gly Pro Gly Gly Gly Ala Cys Glu 
            340                 345                 350         


Pro Arg Gly Gly Glu Pro Ser Ser Gly Pro Val Arg Arg Glu Leu Lys 
        355                 360                 365             


Gln Phe Leu Gly Trp Leu Lys Lys His Ala Tyr Cys Ser Asn Leu Ser 
    370                 375                 380                 


Phe Arg Leu Tyr Asp Gln Trp Arg Ala Trp Met Gln Lys Ser His Lys 
385                 390                 395                 400 


Thr Arg Asn Gln Asp Glu Gly Ile Leu Pro Ser Gly Arg Arg Gly Thr 
                405                 410                 415     


Ala Arg Gly Pro Ala Arg 
            420         


<210>  3543
<211>  173
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3543

Xaa Gln Asp Asn Thr Cys Glu Glu Tyr His Thr Val Gly Pro His Ser 
1               5                   10                  15      


Cys His Ile Pro Lys Asp Leu Ala Leu Phe Thr Pro Tyr Glu Ile Trp 
            20                  25                  30          


Val Glu Ala Thr Asn Arg Leu Gly Ser Ala Arg Ser Asp Val Leu Thr 
        35                  40                  45              


Leu Asp Ile Leu Asp Val Val Thr Thr Asp Pro Pro Pro Asp Val His 
    50                  55                  60                  


Val Ser Arg Val Gly Gly Leu Glu Asp Gln Leu Ser Val Arg Trp Val 
65                  70                  75                  80  


Ser Pro Pro Ala Leu Lys Asp Phe Leu Phe Gln Ala Lys Tyr Gln Ile 
                85                  90                  95      


Arg Tyr Arg Val Glu Asp Ser Val Asp Trp Lys Val Val Asp Asp Val 
            100                 105                 110         


Ser Asn Gln Thr Ser Cys Arg Leu Ala Gly Leu Lys Pro Gly Thr Val 
        115                 120                 125             


Tyr Phe Val Gln Val Arg Cys Asn Pro Phe Gly Ile Tyr Gly Ser Lys 
    130                 135                 140                 


Lys Ala Gly Ile Trp Lys Arg Pro Gly Pro Gly Gly Gly Ala Cys Glu 
145                 150                 155                 160 


Pro Arg Gly Gly Glu Pro Ser Ser Gly Pro Val Arg Arg 
                165                 170             


<210>  3544
<211>  102
<212>  PRT
<213>  Homo Sapiens

<400>  3544

Met Glu Lys Leu Leu Cys Phe Leu Val Leu Thr Ser Leu Ser His Ala 
1               5                   10                  15      


Phe Gly Gln Thr Asp Met Ser Arg Lys Ala Phe Val Phe Pro Lys Glu 
            20                  25                  30          


Ser Asp Thr Ser Tyr Val Ser Leu Lys Ala Pro Leu Thr Lys Pro Leu 
        35                  40                  45              


Lys Ala Phe Thr Val Cys Leu His Phe Tyr Thr Glu Leu Ser Ser Thr 
    50                  55                  60                  


His Glu Ile Asn Thr Ile Tyr Leu Gly Gly Pro Phe Ser Pro Asn Val 
65                  70                  75                  80  


Leu Asn Trp Arg Ala Leu Lys Tyr Glu Val Gln Gly Glu Val Phe Thr 
                85                  90                  95      


Lys Pro Gln Leu Trp Pro 
            100         


<210>  3545
<211>  102
<212>  PRT
<213>  Homo Sapiens

<400>  3545

Met Glu Lys Leu Leu Cys Phe Leu Val Leu Thr Ser Leu Ser His Ala 
1               5                   10                  15      


Phe Gly Gln Thr Asp Met Ser Arg Lys Ala Phe Val Phe Pro Lys Glu 
            20                  25                  30          


Ser Asp Thr Ser Tyr Val Ser Leu Lys Ala Pro Leu Thr Lys Pro Leu 
        35                  40                  45              


Lys Ala Phe Thr Val Cys Leu His Phe Tyr Thr Glu Leu Ser Ser Thr 
    50                  55                  60                  


His Glu Ile Asn Thr Ile Tyr Leu Gly Gly Pro Phe Ser Pro Asn Val 
65                  70                  75                  80  


Leu Asn Trp Arg Ala Leu Lys Tyr Glu Val Gln Gly Glu Val Phe Thr 
                85                  90                  95      


Lys Pro Gln Leu Trp Pro 
            100         


<210>  3546
<211>  91
<212>  PRT
<213>  Homo Sapiens

<400>  3546

Met Glu Lys Leu Leu Cys Phe Leu Val Leu Thr Ser Leu Ser His Ala 
1               5                   10                  15      


Phe Gly Gln Thr Asp Met Ser Arg Lys Ala Phe Val Phe Pro Lys Glu 
            20                  25                  30          


Ser Asp Thr Ser Tyr Val Ser Leu Lys Ala Pro Leu Thr Lys Pro Leu 
        35                  40                  45              


Lys Ala Phe Thr Val Cys Leu His Phe Tyr Thr Glu Leu Ser Ser Thr 
    50                  55                  60                  


Arg Gly Pro Asn Val Leu Asn Trp Arg Ala Leu Lys Tyr Glu Val Gln 
65                  70                  75                  80  


Gly Glu Val Phe Thr Lys Pro Gln Leu Trp Pro 
                85                  90      


<210>  3547
<211>  224
<212>  PRT
<213>  Homo Sapiens

<400>  3547

Met Glu Lys Leu Leu Cys Phe Leu Val Leu Thr Ser Leu Ser His Ala 
1               5                   10                  15      


Phe Gly Gln Thr Asp Met Ser Arg Lys Ala Phe Val Phe Pro Lys Glu 
            20                  25                  30          


Ser Asp Thr Ser Tyr Val Ser Leu Lys Ala Pro Leu Thr Lys Pro Leu 
        35                  40                  45              


Lys Ala Phe Thr Val Cys Leu His Phe Tyr Thr Glu Leu Ser Ser Thr 
    50                  55                  60                  


Arg Gly Tyr Ser Ile Phe Ser Tyr Ala Thr Lys Arg Gln Asp Asn Glu 
65                  70                  75                  80  


Ile Leu Ile Phe Trp Ser Lys Asp Ile Gly Tyr Ser Phe Thr Val Gly 
                85                  90                  95      


Gly Ser Glu Ile Leu Phe Glu Val Pro Glu Val Thr Val Ala Pro Val 
            100                 105                 110         


His Ile Cys Thr Ser Trp Glu Ser Ala Ser Gly Ile Val Glu Phe Trp 
        115                 120                 125             


Val Asp Gly Lys Pro Arg Val Arg Lys Ser Leu Lys Lys Gly Tyr Thr 
    130                 135                 140                 


Val Gly Ala Glu Ala Ser Ile Ile Leu Gly Gln Glu Gln Asp Ser Phe 
145                 150                 155                 160 


Gly Gly Asn Phe Glu Gly Ser Gln Ser Leu Val Gly Asp Ile Gly Asn 
                165                 170                 175     


Val Asn Met Trp Asp Phe Val Leu Ser Pro Asp Glu Ile Asn Thr Ile 
            180                 185                 190         


Tyr Leu Gly Gly Pro Phe Ser Pro Asn Val Leu Asn Trp Arg Ala Leu 
        195                 200                 205             


Lys Tyr Glu Val Gln Gly Glu Val Phe Thr Lys Pro Gln Leu Trp Pro 
    210                 215                 220                 


<210>  3548
<211>  46
<212>  PRT
<213>  Homo Sapiens

<400>  3548

Met Trp Asp Phe Val Leu Ser Pro Asp Glu Ile Asn Thr Ile Tyr Leu 
1               5                   10                  15      


Gly Gly Pro Phe Ser Pro Asn Val Leu Asn Trp Arg Ala Leu Lys Tyr 
            20                  25                  30          


Glu Val Gln Gly Glu Val Phe Thr Lys Pro Gln Leu Trp Pro 
        35                  40                  45      


<210>  3549
<211>  645
<212>  PRT
<213>  Homo Sapiens

<400>  3549

Met Ala Pro Ser Ala Asp Pro Gly Met Ser Arg Met Leu Pro Phe Leu 
1               5                   10                  15      


Leu Leu Leu Trp Phe Leu Pro Ile Thr Glu Gly Ser Gln Arg Ala Glu 
            20                  25                  30          


Pro Met Phe Thr Ala Val Thr Asn Ser Val Leu Pro Pro Asp Tyr Asp 
        35                  40                  45              


Ser Asn Pro Thr Gln Leu Asn Tyr Gly Val Ala Val Thr Asp Val Asp 
    50                  55                  60                  


His Asp Gly Asp Phe Glu Ile Val Val Ala Gly Tyr Asn Gly Pro Asn 
65                  70                  75                  80  


Leu Val Leu Lys Tyr Asp Arg Ala Gln Lys Arg Leu Val Asn Ile Ala 
                85                  90                  95      


Val Asp Glu Arg Ser Ser Pro Tyr Tyr Ala Leu Arg Asp Arg Gln Gly 
            100                 105                 110         


Asn Ala Ile Gly Val Thr Ala Cys Asp Ile Asp Gly Asp Gly Arg Glu 
        115                 120                 125             


Glu Ile Tyr Phe Leu Asn Thr Asn Asn Ala Phe Ser Gly Val Ala Thr 
    130                 135                 140                 


Tyr Thr Asp Lys Leu Phe Lys Phe Arg Asn Asn Arg Trp Glu Asp Ile 
145                 150                 155                 160 


Leu Ser Asp Glu Val Asn Val Ala Arg Gly Val Ala Ser Leu Phe Ala 
                165                 170                 175     


Gly Arg Ser Val Ala Cys Val Asp Arg Lys Gly Ser Gly Arg Tyr Ser 
            180                 185                 190         


Ile Tyr Ile Ala Asn Tyr Ala Tyr Gly Asn Val Gly Pro Asp Ala Leu 
        195                 200                 205             


Ile Glu Met Asp Pro Glu Ala Ser Asp Leu Ser Arg Gly Ile Leu Ala 
    210                 215                 220                 


Leu Arg Asp Val Ala Ala Glu Ala Gly Val Ser Lys Tyr Thr Gly Gly 
225                 230                 235                 240 


Arg Gly Val Ser Val Gly Pro Ile Leu Ser Ser Ser Ala Ser Asp Ile 
                245                 250                 255     


Phe Cys Asp Asn Glu Asn Gly Pro Asn Phe Leu Phe His Asn Arg Gly 
            260                 265                 270         


Asp Gly Thr Phe Val Asp Ala Ala Ala Ser Ala Gly Val Asp Asp Pro 
        275                 280                 285             


His Gln His Gly Arg Gly Val Ala Leu Ala Asp Phe Asn Arg Asp Gly 
    290                 295                 300                 


Lys Val Asp Ile Val Tyr Gly Asn Trp Asn Gly Pro His Arg Leu Tyr 
305                 310                 315                 320 


Leu Gln Met Ser Thr His Gly Lys Val Arg Phe Arg Asp Ile Ala Ser 
                325                 330                 335     


Pro Lys Phe Ser Met Pro Ser Pro Val Arg Thr Val Ile Thr Ala Asp 
            340                 345                 350         


Phe Asp Asn Asp Gln Glu Leu Glu Ile Phe Phe Asn Asn Ile Ala Tyr 
        355                 360                 365             


Arg Ser Ser Ser Ala Asn Arg Leu Phe Arg Val Ile Arg Arg Glu His 
    370                 375                 380                 


Gly Asp Pro Leu Ile Glu Glu Leu Asn Pro Gly Asp Ala Leu Glu Pro 
385                 390                 395                 400 


Glu Gly Arg Gly Thr Gly Gly Val Val Thr Asp Phe Asp Gly Asp Gly 
                405                 410                 415     


Met Leu Asp Leu Ile Leu Ser His Gly Glu Ser Met Ala Gln Pro Leu 
            420                 425                 430         


Ser Val Phe Arg Gly Asn Gln Gly Phe Asn Asn Asn Trp Leu Arg Val 
        435                 440                 445             


Val Pro Arg Thr Arg Phe Gly Ala Phe Ala Arg Gly Ala Lys Val Val 
    450                 455                 460                 


Leu Tyr Thr Lys Lys Ser Gly Ala His Leu Arg Ile Ile Asp Gly Gly 
465                 470                 475                 480 


Ser Gly Tyr Leu Cys Glu Met Glu Pro Val Ala His Phe Gly Leu Gly 
                485                 490                 495     


Lys Asp Glu Ala Ser Ser Val Glu Val Thr Trp Pro Asp Gly Lys Met 
            500                 505                 510         


Val Ser Arg Asn Val Ala Ser Gly Glu Met Asn Ser Val Leu Glu Ile 
        515                 520                 525             


Leu Tyr Pro Arg Asp Glu Asp Thr Leu Gln Asp Pro Ala Pro Leu Glu 
    530                 535                 540                 


Cys Gly Gln Gly Phe Ser Gln Gln Glu Asn Gly His Cys Met Asp Thr 
545                 550                 555                 560 


Asn Glu Cys Ile Gln Phe Pro Phe Val Cys Pro Arg Asp Lys Pro Val 
                565                 570                 575     


Cys Val Asn Thr Tyr Gly Ser Tyr Arg Cys Arg Thr Asn Lys Lys Cys 
            580                 585                 590         


Ser Arg Gly Tyr Glu Pro Asn Glu Asp Gly Thr Ala Cys Val Ala Gln 
        595                 600                 605             


Val Ala Phe Leu Gly Gly Tyr Ser Ser Ala Ala Ser Arg Ile Ser Glu 
    610                 615                 620                 


Pro Leu Ser Arg Ala Ser Tyr Leu Ser Leu Gly Leu Gly Leu Cys Leu 
625                 630                 635                 640 


Gln Leu Tyr Ala Leu 
                645 


<210>  3550
<211>  661
<212>  PRT
<213>  Homo Sapiens

<400>  3550

Met Ala Pro Ser Ala Asp Pro Gly Met Ser Arg Met Leu Pro Phe Leu 
1               5                   10                  15      


Leu Leu Leu Trp Phe Leu Pro Ile Thr Glu Gly Ser Gln Arg Ala Glu 
            20                  25                  30          


Pro Met Phe Thr Ala Val Thr Asn Ser Val Leu Pro Pro Asp Tyr Asp 
        35                  40                  45              


Ser Asn Pro Thr Gln Leu Asn Tyr Gly Val Ala Val Thr Asp Val Asp 
    50                  55                  60                  


His Asp Gly Asp Phe Glu Ile Val Val Ala Gly Tyr Asn Gly Pro Asn 
65                  70                  75                  80  


Leu Val Leu Lys Tyr Asp Arg Ala Gln Lys Arg Leu Val Asn Ile Ala 
                85                  90                  95      


Val Asp Glu Arg Ser Ser Pro Tyr Tyr Ala Leu Arg Asp Arg Gln Gly 
            100                 105                 110         


Asn Ala Ile Gly Val Thr Ala Cys Asp Ile Asp Gly Asp Gly Arg Glu 
        115                 120                 125             


Glu Ile Tyr Phe Leu Asn Thr Asn Asn Ala Phe Ser Gly Val Ala Thr 
    130                 135                 140                 


Tyr Thr Asp Lys Leu Phe Lys Phe Arg Asn Asn Arg Trp Glu Asp Ile 
145                 150                 155                 160 


Leu Ser Asp Glu Val Asn Val Ala Arg Gly Val Ala Ser Leu Phe Ala 
                165                 170                 175     


Gly Arg Ser Val Ala Cys Val Asp Arg Lys Gly Ser Gly Arg Tyr Ser 
            180                 185                 190         


Ile Tyr Ile Ala Asn Tyr Ala Tyr Gly Asn Val Gly Pro Asp Ala Leu 
        195                 200                 205             


Ile Glu Met Asp Pro Glu Ala Ser Asp Leu Ser Arg Gly Ile Leu Ala 
    210                 215                 220                 


Leu Arg Asp Val Ala Ala Glu Ala Gly Val Ser Lys Tyr Thr Gly Gly 
225                 230                 235                 240 


Arg Gly Val Ser Val Gly Pro Ile Leu Ser Ser Ser Ala Ser Asp Ile 
                245                 250                 255     


Phe Cys Asp Asn Glu Asn Gly Pro Asn Phe Leu Phe His Asn Arg Gly 
            260                 265                 270         


Asp Gly Thr Phe Val Asp Ala Ala Ala Ser Ala Gly Val Asp Asp Pro 
        275                 280                 285             


His Gln His Gly Arg Gly Val Ala Leu Ala Asp Phe Asn Arg Asp Gly 
    290                 295                 300                 


Lys Val Asp Ile Val Tyr Gly Asn Trp Asn Gly Pro His Arg Leu Tyr 
305                 310                 315                 320 


Leu Gln Met Ser Thr His Gly Lys Val Arg Phe Arg Asp Ile Ala Ser 
                325                 330                 335     


Pro Lys Phe Ser Met Pro Ser Pro Val Arg Thr Val Ile Thr Ala Asp 
            340                 345                 350         


Phe Asp Asn Asp Gln Glu Leu Glu Ile Phe Phe Asn Asn Ile Ala Tyr 
        355                 360                 365             


Arg Ser Ser Ser Ala Asn Arg Leu Phe Arg Val Ile Arg Arg Glu His 
    370                 375                 380                 


Gly Asp Pro Leu Ile Glu Glu Leu Asn Pro Gly Asp Ala Leu Glu Pro 
385                 390                 395                 400 


Glu Gly Arg Gly Thr Gly Gly Val Val Thr Asp Phe Asp Gly Asp Gly 
                405                 410                 415     


Met Leu Asp Leu Ile Leu Ser His Gly Glu Ser Met Ala Gln Pro Leu 
            420                 425                 430         


Ser Val Phe Arg Gly Asn Gln Gly Phe Asn Asn Asn Trp Leu Arg Val 
        435                 440                 445             


Val Pro Arg Thr Arg Phe Gly Ala Phe Ala Arg Gly Ala Lys Val Val 
    450                 455                 460                 


Leu Tyr Thr Lys Lys Ser Gly Ala His Leu Arg Ile Ile Asp Gly Gly 
465                 470                 475                 480 


Ser Gly Tyr Leu Cys Glu Met Glu Pro Val Ala His Phe Gly Leu Gly 
                485                 490                 495     


Lys Asp Glu Ala Ser Ser Val Glu Val Thr Trp Pro Asp Gly Lys Met 
            500                 505                 510         


Val Ser Arg Asn Val Ala Ser Gly Glu Met Asn Ser Val Leu Glu Ile 
        515                 520                 525             


Leu Tyr Pro Arg Asp Glu Asp Thr Leu Gln Asp Pro Ala Pro Leu Glu 
    530                 535                 540                 


Cys Gly Gln Gly Phe Ser Gln Gln Glu Asn Gly His Cys Met Asp Thr 
545                 550                 555                 560 


Asn Glu Cys Ile Gln Phe Pro Phe Val Cys Pro Arg Asp Lys Pro Val 
                565                 570                 575     


Cys Val Asn Thr Tyr Gly Ser Tyr Arg Cys Arg Thr Asn Lys Lys Cys 
            580                 585                 590         


Ser Arg Gly Tyr Glu Pro Asn Glu Asp Gly Thr Ala Cys Val Gly Thr 
        595                 600                 605             


Leu Gly Gln Ser Pro Gly Pro Arg Pro Thr Thr Pro Thr Ala Ala Ala 
    610                 615                 620                 


Ala Thr Ala Ala Ala Ala Ala Ala Ala Gly Ala Ala Thr Ala Ala Pro 
625                 630                 635                 640 


Val Leu Val Asp Gly Asp Leu Asn Leu Gly Ser Val Val Lys Glu Ser 
                645                 650                 655     


Cys Glu Pro Ser Cys 
            660     


<210>  3551
<211>  637
<212>  PRT
<213>  Homo Sapiens

<400>  3551

Met Ser Arg Met Leu Pro Phe Leu Leu Leu Leu Trp Phe Leu Pro Ile 
1               5                   10                  15      


Thr Glu Gly Ser Gln Arg Ala Glu Pro Met Phe Thr Ala Val Thr Asn 
            20                  25                  30          


Ser Val Leu Pro Pro Asp Tyr Asp Ser Asn Pro Thr Gln Leu Asn Tyr 
        35                  40                  45              


Gly Val Ala Val Thr Asp Val Asp His Asp Gly Asp Phe Glu Ile Val 
    50                  55                  60                  


Val Ala Gly Tyr Asn Gly Pro Asn Leu Val Leu Lys Tyr Asp Arg Ala 
65                  70                  75                  80  


Gln Lys Arg Leu Val Asn Ile Ala Val Asp Glu Arg Ser Ser Pro Tyr 
                85                  90                  95      


Tyr Ala Leu Arg Asp Arg Gln Gly Asn Ala Ile Gly Val Thr Ala Cys 
            100                 105                 110         


Asp Ile Asp Gly Asp Gly Arg Glu Glu Ile Tyr Phe Leu Asn Thr Asn 
        115                 120                 125             


Asn Ala Phe Ser Gly Val Ala Thr Tyr Thr Asp Lys Leu Phe Lys Phe 
    130                 135                 140                 


Arg Asn Asn Arg Trp Glu Asp Ile Leu Ser Asp Glu Val Asn Val Ala 
145                 150                 155                 160 


Arg Gly Val Ala Ser Leu Phe Ala Gly Arg Ser Val Ala Cys Val Asp 
                165                 170                 175     


Arg Lys Gly Ser Gly Arg Tyr Ser Ile Tyr Ile Ala Asn Tyr Ala Tyr 
            180                 185                 190         


Gly Asn Val Gly Pro Asp Ala Leu Ile Glu Met Asp Pro Glu Ala Ser 
        195                 200                 205             


Asp Leu Ser Arg Gly Ile Leu Ala Leu Arg Asp Val Ala Ala Glu Ala 
    210                 215                 220                 


Gly Val Ser Lys Tyr Thr Gly Gly Arg Gly Val Ser Val Gly Pro Ile 
225                 230                 235                 240 


Leu Ser Ser Ser Ala Ser Asp Ile Phe Cys Asp Asn Glu Asn Gly Pro 
                245                 250                 255     


Asn Phe Leu Phe His Asn Arg Gly Asp Gly Thr Phe Val Asp Ala Ala 
            260                 265                 270         


Ala Ser Ala Gly Val Asp Asp Pro His Gln His Gly Arg Gly Val Ala 
        275                 280                 285             


Leu Ala Asp Phe Asn Arg Asp Gly Lys Val Asp Ile Val Tyr Gly Asn 
    290                 295                 300                 


Trp Asn Gly Pro His Arg Leu Tyr Leu Gln Met Ser Thr His Gly Lys 
305                 310                 315                 320 


Val Arg Phe Arg Asp Ile Ala Ser Pro Lys Phe Ser Met Pro Ser Pro 
                325                 330                 335     


Val Arg Thr Val Ile Thr Ala Asp Phe Asp Asn Asp Gln Glu Leu Glu 
            340                 345                 350         


Ile Phe Phe Asn Asn Ile Ala Tyr Arg Ser Ser Ser Ala Asn Arg Leu 
        355                 360                 365             


Phe Arg Val Ile Arg Arg Glu His Gly Asp Pro Leu Ile Glu Glu Leu 
    370                 375                 380                 


Asn Pro Gly Asp Ala Leu Glu Pro Glu Gly Arg Gly Thr Gly Gly Val 
385                 390                 395                 400 


Val Thr Asp Phe Asp Gly Asp Gly Met Leu Asp Leu Ile Leu Ser His 
                405                 410                 415     


Gly Glu Ser Met Ala Gln Pro Leu Ser Val Phe Arg Gly Asn Gln Gly 
            420                 425                 430         


Phe Asn Asn Asn Trp Leu Arg Val Val Pro Arg Thr Arg Phe Gly Ala 
        435                 440                 445             


Phe Ala Arg Gly Ala Lys Val Val Leu Tyr Thr Lys Lys Ser Gly Ala 
    450                 455                 460                 


His Leu Arg Ile Ile Asp Gly Gly Ser Gly Tyr Leu Cys Glu Met Glu 
465                 470                 475                 480 


Pro Val Ala His Phe Gly Leu Gly Lys Asp Glu Ala Ser Ser Val Glu 
                485                 490                 495     


Val Thr Trp Pro Asp Gly Lys Met Val Ser Arg Asn Val Ala Ser Gly 
            500                 505                 510         


Glu Met Asn Ser Val Leu Glu Ile Leu Tyr Pro Arg Asp Glu Asp Thr 
        515                 520                 525             


Leu Gln Asp Pro Ala Pro Leu Glu Cys Gly Gln Gly Phe Ser Gln Gln 
    530                 535                 540                 


Glu Asn Gly His Cys Met Asp Thr Asn Glu Cys Ile Gln Phe Pro Phe 
545                 550                 555                 560 


Val Cys Pro Arg Asp Lys Pro Val Cys Val Asn Thr Tyr Gly Ser Tyr 
                565                 570                 575     


Arg Cys Arg Thr Asn Lys Lys Cys Ser Arg Gly Tyr Glu Pro Asn Glu 
            580                 585                 590         


Asp Gly Thr Ala Cys Val Ala Gln Val Ala Phe Leu Gly Gly Tyr Ser 
        595                 600                 605             


Ser Ala Ala Ser Arg Ile Ser Glu Pro Leu Ser Arg Ala Ser Tyr Leu 
    610                 615                 620                 


Ser Leu Gly Leu Gly Leu Cys Leu Gln Leu Tyr Ala Leu 
625                 630                 635         


<210>  3552
<211>  79
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3552

Xaa Asp Glu Asp Thr Leu Gln Asp Pro Ala Pro Leu Glu Thr Pro Met 
1               5                   10                  15      


Asn Ala Ser Ser Ser His Ser Cys Ala Leu Glu Thr Ser Pro Tyr Val 
            20                  25                  30          


Ser Thr Pro Met Glu Ala Thr Gly Ala Gly Pro Thr Arg Ser Ala Val 
        35                  40                  45              


Gly Ala Thr Ser Pro Thr Arg Met Ala Gln Pro Ala Trp Lys Glu Pro 
    50                  55                  60                  


Cys Tyr Leu Val Ser Ala Ile Ser Leu Glu Asn Arg Met Leu Leu 
65                  70                  75                  


<210>  3553
<211>  524
<212>  PRT
<213>  Homo Sapiens

<400>  3553

Tyr Ala Leu Arg Asp Arg Gln Gly Asn Ala Ile Gly Val Thr Ala Cys 
1               5                   10                  15      


Asp Ile Asp Gly Asp Gly Arg Glu Glu Ile Tyr Phe Leu Asn Thr Asn 
            20                  25                  30          


Asn Ala Phe Ser Gly Val Ala Thr Tyr Thr Asp Lys Leu Phe Lys Phe 
        35                  40                  45              


Arg Asn Asn Arg Trp Glu Asp Ile Leu Ser Asp Glu Val Asn Val Ala 
    50                  55                  60                  


Arg Gly Val Ala Ser Leu Phe Ala Gly Arg Ser Val Ala Cys Val Asp 
65                  70                  75                  80  


Arg Lys Gly Ser Gly Arg Tyr Ser Ile Tyr Ile Ala Asn Tyr Ala Tyr 
                85                  90                  95      


Gly Asn Val Gly Pro Asp Ala Leu Ile Glu Met Asp Pro Glu Ala Ser 
            100                 105                 110         


Asp Leu Ser Arg Gly Ile Leu Ala Leu Arg Asp Val Ala Ala Glu Ala 
        115                 120                 125             


Gly Val Ser Lys Tyr Thr Gly Gly Arg Gly Val Ser Val Gly Pro Ile 
    130                 135                 140                 


Leu Ser Ser Ser Ala Ser Asp Ile Phe Cys Asp Asn Glu Asn Gly Pro 
145                 150                 155                 160 


Asn Phe Leu Phe His Asn Arg Gly Asp Gly Thr Phe Val Asp Ala Ala 
                165                 170                 175     


Ala Ser Ala Gly Val Asp Asp Pro His Gln His Gly Arg Gly Val Ala 
            180                 185                 190         


Leu Ala Asp Phe Asn Arg Asp Gly Lys Val Asp Ile Val Tyr Gly Asn 
        195                 200                 205             


Trp Asn Gly Pro His Arg Leu Tyr Leu Gln Met Ser Thr His Gly Lys 
    210                 215                 220                 


Val Arg Phe Arg Asp Ile Ala Ser Pro Lys Phe Ser Met Pro Ser Pro 
225                 230                 235                 240 


Val Arg Thr Val Ile Thr Ala Asp Phe Asp Asn Asp Gln Glu Leu Glu 
                245                 250                 255     


Ile Phe Phe Asn Asn Ile Ala Tyr Arg Ser Ser Ser Ala Asn Arg Leu 
            260                 265                 270         


Phe Arg Val Ile Arg Arg Glu His Gly Asp Pro Leu Ile Glu Glu Leu 
        275                 280                 285             


Asn Pro Gly Asp Ala Leu Glu Pro Glu Gly Arg Gly Thr Gly Gly Val 
    290                 295                 300                 


Val Thr Asp Phe Asp Gly Asp Gly Met Leu Asp Leu Ile Leu Ser His 
305                 310                 315                 320 


Gly Glu Ser Met Ala Gln Pro Leu Ser Val Phe Arg Gly Asn Gln Gly 
                325                 330                 335     


Phe Asn Asn Asn Trp Leu Arg Val Val Pro Arg Thr Arg Phe Gly Ala 
            340                 345                 350         


Phe Ala Arg Gly Ala Lys Val Val Leu Tyr Thr Lys Lys Ser Gly Ala 
        355                 360                 365             


His Leu Arg Ile Ile Asp Gly Gly Ser Gly Tyr Leu Cys Glu Met Glu 
    370                 375                 380                 


Pro Val Ala His Phe Gly Leu Gly Lys Asp Glu Ala Ser Ser Val Glu 
385                 390                 395                 400 


Val Thr Trp Pro Asp Gly Lys Met Val Ser Arg Asn Val Ala Ser Gly 
                405                 410                 415     


Glu Met Asn Ser Val Leu Glu Ile Leu Tyr Pro Arg Asp Glu Asp Thr 
            420                 425                 430         


Leu Gln Asp Pro Ala Pro Leu Glu Thr Pro Met Asn Ala Ser Ser Ser 
        435                 440                 445             


His Ser Cys Ala Leu Glu Thr Ser Pro Tyr Val Ser Thr Pro Met Glu 
    450                 455                 460                 


Ala Thr Gly Ala Gly Pro Thr Arg Ser Ala Val Gly Ala Thr Ser Pro 
465                 470                 475                 480 


Thr Arg Met Ala Gln Pro Ala Trp Gly Leu Ser Ala Ser His Arg Ala 
                485                 490                 495     


Pro Ala Pro Pro Pro Pro Pro Leu Leu Leu Pro Leu Pro Leu Leu Leu 
            500                 505                 510         


Pro Leu Leu Glu Leu Pro Leu Leu His Arg Ser Ser 
        515                 520                 


<210>  3554
<211>  401
<212>  PRT
<213>  Homo Sapiens

<400>  3554

Met Glu Pro Gly Arg Arg Gly Ala Ala Ala Leu Leu Ala Leu Leu Cys 
1               5                   10                  15      


Val Ala Cys Ala Leu Arg Ala Gly Arg Ala Gln Tyr Glu Arg Tyr Ser 
            20                  25                  30          


Phe Arg Ser Phe Pro Arg Asp Glu Leu Met Pro Leu Glu Ser Ala Tyr 
        35                  40                  45              


Arg His Ala Leu Asp Lys Tyr Ser Gly Glu His Trp Ala Glu Ser Val 
    50                  55                  60                  


Gly Tyr Leu Glu Ile Ser Leu Arg Leu His Arg Leu Leu Arg Asp Ser 
65                  70                  75                  80  


Glu Ala Phe Cys His Arg Asn Cys Ser Ala Ala Pro Gln Pro Glu Pro 
                85                  90                  95      


Ala Ala Gly Leu Ala Ser Tyr Pro Glu Leu Arg Leu Phe Gly Gly Leu 
            100                 105                 110         


Leu Arg Arg Ala His Cys Leu Lys Arg Cys Lys Gln Gly Leu Pro Ala 
        115                 120                 125             


Phe Arg Gln Ser Gln Pro Ser Arg Glu Val Leu Ala Asp Phe Gln Arg 
    130                 135                 140                 


Arg Glu Pro Tyr Lys Phe Leu Gln Phe Ala Tyr Phe Lys Ala Asn Asn 
145                 150                 155                 160 


Leu Pro Lys Ala Ile Ala Ala Ala His Thr Phe Leu Leu Lys His Pro 
                165                 170                 175     


Asp Asp Glu Met Met Lys Arg Asn Met Ala Tyr Tyr Lys Ser Leu Pro 
            180                 185                 190         


Gly Ala Glu Asp Tyr Ile Lys Asp Leu Glu Thr Lys Ser Tyr Glu Ser 
        195                 200                 205             


Leu Phe Ile Arg Ala Val Arg Ala Tyr Asn Gly Glu Asn Trp Arg Thr 
    210                 215                 220                 


Ser Ile Thr Asp Met Glu Leu Ala Leu Pro Asp Phe Phe Lys Ala Phe 
225                 230                 235                 240 


Tyr Glu Cys Leu Ala Ala Cys Glu Gly Ser Arg Glu Ile Lys Asp Phe 
                245                 250                 255     


Lys Asp Phe Tyr Leu Ser Ile Ala Asp His Tyr Val Glu Val Leu Glu 
            260                 265                 270         


Cys Lys Ile Gln Cys Glu Glu Asn Leu Thr Pro Val Ile Gly Gly Tyr 
        275                 280                 285             


Pro Val Glu Lys Phe Val Ala Thr Met Tyr His Tyr Leu Gln Phe Ala 
    290                 295                 300                 


Tyr Tyr Lys Leu Asn Asp Leu Lys Asn Ala Ala Pro Cys Ala Val Ser 
305                 310                 315                 320 


Tyr Leu Leu Phe Asp Gln Asn Asp Lys Val Met Gln Gln Asn Leu Val 
                325                 330                 335     


Tyr Tyr Gln Tyr His Arg Asp Thr Trp Gly Leu Ser Asp Glu His Phe 
            340                 345                 350         


Gln Pro Arg Pro Glu Ala Val Gln Phe Phe Asn Val Thr Thr Leu Gln 
        355                 360                 365             


Lys Glu Leu Tyr Asp Phe Ala Lys Glu Asn Ile Met Asp Asp Asp Glu 
    370                 375                 380                 


Gly Glu Val Val Glu Tyr Val Asp Asp Leu Leu Glu Leu Glu Glu Thr 
385                 390                 395                 400 


Ser 
    


<210>  3555
<211>  358
<212>  PRT
<213>  Homo Sapiens

<400>  3555

Met Glu Pro Gly Arg Arg Gly Ala Ala Ala Leu Leu Ala Leu Leu Cys 
1               5                   10                  15      


Val Ala Cys Ala Leu Arg Ala Gly Arg Ala Gln Tyr Glu Arg Tyr Ser 
            20                  25                  30          


Phe Arg Ser Phe Pro Arg Asp Glu Leu Met Pro Leu Glu Ser Ala Tyr 
        35                  40                  45              


Arg His Ala Leu Asp Lys Tyr Ser Gly Glu His Trp Ala Glu Ser Val 
    50                  55                  60                  


Gly Tyr Leu Glu Ile Ser Leu Arg Leu His Arg Leu Leu Arg Asp Ser 
65                  70                  75                  80  


Glu Ala Phe Cys His Arg Asn Cys Ser Ala Ala Pro Gln Pro Glu Pro 
                85                  90                  95      


Ala Ala Gly Leu Ala Ser Tyr Pro Glu Leu Arg Leu Phe Gly Gly Leu 
            100                 105                 110         


Leu Arg Arg Ala His Cys Leu Lys Arg Cys Lys Gln Gly Leu Pro Ala 
        115                 120                 125             


Phe Arg Gln Ser Gln Pro Ser Arg Glu Val Leu Ala Asp Phe Gln Arg 
    130                 135                 140                 


Arg Glu Pro Tyr Lys Phe Leu Gln Phe Ala Tyr Phe Lys Ala Asn Asn 
145                 150                 155                 160 


Leu Pro Lys Ala Ile Ala Ala Ala His Thr Phe Leu Leu Lys His Pro 
                165                 170                 175     


Asp Asp Glu Met Met Lys Arg Asn Met Ala Tyr Tyr Lys Ser Leu Pro 
            180                 185                 190         


Gly Ala Glu Asp Tyr Ile Lys Asp Leu Glu Thr Lys Ser Tyr Glu Ser 
        195                 200                 205             


Leu Phe Ile Arg Ala Val Arg Ala Tyr Asn Gly Glu Asn Trp Arg Thr 
    210                 215                 220                 


Ser Ile Thr Asp Met Glu Leu Ala Leu Pro Asp Phe Phe Lys Ala Phe 
225                 230                 235                 240 


Tyr Glu Cys Leu Ala Ala Cys Glu Gly Ser Arg Glu Ile Lys Asp Phe 
                245                 250                 255     


Lys Asp Phe Tyr Leu Ser Ile Ala Val Asn Asp Leu Lys Asn Ala Ala 
            260                 265                 270         


Pro Cys Ala Val Ser Tyr Leu Leu Phe Asp Gln Asn Asp Lys Val Met 
        275                 280                 285             


Gln Gln Asn Leu Val Tyr Tyr Gln Tyr His Arg Asp Thr Trp Gly Leu 
    290                 295                 300                 


Ser Asp Glu His Phe Gln Pro Arg Pro Glu Ala Val Gln Phe Phe Asn 
305                 310                 315                 320 


Val Thr Thr Leu Gln Lys Glu Leu Tyr Asp Phe Ala Lys Glu Asn Ile 
                325                 330                 335     


Met Asp Asp Asp Glu Gly Glu Val Val Glu Tyr Val Asp Asp Leu Leu 
            340                 345                 350         


Glu Leu Glu Glu Thr Ser 
        355             


<210>  3556
<211>  593
<212>  PRT
<213>  Homo Sapiens

<400>  3556

Met Ala Ala Thr Val Ala Thr Ala Ala Ala Val Ala Pro Ala Pro Ala 
1               5                   10                  15      


Pro Gly Thr Asp Ser Ala Ser Ser Val His Trp Phe Arg Lys Gly Leu 
            20                  25                  30          


Arg Leu His Asp Asn Pro Ala Leu Leu Ala Ala Val Arg Gly Ala Arg 
        35                  40                  45              


Cys Val Arg Cys Val Tyr Ile Leu Asp Pro Trp Phe Ala Ala Ser Ser 
    50                  55                  60                  


Ser Val Gly Ile Asn Arg Trp Arg Phe Leu Leu Gln Ser Leu Glu Asp 
65                  70                  75                  80  


Leu Asp Thr Ser Leu Arg Lys Leu Asn Ser Arg Leu Phe Val Val Arg 
                85                  90                  95      


Gly Gln Pro Ala Asp Val Phe Pro Arg Leu Phe Lys Glu Trp Gly Val 
            100                 105                 110         


Thr Arg Leu Thr Phe Glu Tyr Asp Ser Glu Pro Phe Gly Lys Glu Arg 
        115                 120                 125             


Asp Ala Ala Ile Met Lys Met Ala Lys Glu Ala Gly Val Glu Val Val 
    130                 135                 140                 


Thr Glu Asn Ser His Thr Leu Tyr Asp Leu Asp Arg Ile Ile Glu Leu 
145                 150                 155                 160 


Asn Gly Gln Lys Pro Pro Leu Thr Tyr Lys Arg Phe Gln Ala Ile Ile 
                165                 170                 175     


Ser Arg Met Glu Leu Pro Lys Lys Pro Val Gly Leu Val Thr Ser Gln 
            180                 185                 190         


Gln Met Glu Ser Cys Arg Ala Glu Ile Gln Glu Asn His Asp Glu Thr 
        195                 200                 205             


Tyr Gly Val Pro Ser Leu Glu Glu Leu Gly Phe Pro Thr Glu Gly Leu 
    210                 215                 220                 


Gly Pro Ala Val Trp Gln Gly Gly Glu Thr Glu Ala Leu Ala Arg Leu 
225                 230                 235                 240 


Asp Lys His Leu Glu Arg Lys Ala Trp Val Ala Asn Tyr Glu Arg Pro 
                245                 250                 255     


Arg Met Asn Ala Asn Ser Leu Leu Ala Ser Pro Thr Gly Leu Ser Pro 
            260                 265                 270         


Tyr Leu Arg Phe Gly Cys Leu Ser Cys Arg Leu Phe Tyr Tyr Arg Leu 
        275                 280                 285             


Trp Asp Leu Tyr Lys Lys Val Lys Arg Asn Ser Thr Pro Pro Leu Ser 
    290                 295                 300                 


Leu Phe Gly Gln Leu Leu Trp Arg Glu Phe Phe Tyr Thr Ala Ala Thr 
305                 310                 315                 320 


Asn Asn Pro Arg Phe Asp Arg Met Glu Gly Asn Pro Ile Cys Ile Gln 
                325                 330                 335     


Ile Pro Trp Asp Arg Asn Pro Glu Ala Leu Ala Lys Trp Ala Glu Gly 
            340                 345                 350         


Lys Thr Gly Phe Pro Trp Ile Asp Ala Ile Met Thr Gln Leu Arg Gln 
        355                 360                 365             


Glu Gly Trp Ile His His Leu Ala Arg His Ala Val Ala Cys Phe Leu 
    370                 375                 380                 


Thr Arg Gly Asp Leu Trp Val Ser Trp Glu Ser Gly Val Arg Val Phe 
385                 390                 395                 400 


Asp Glu Leu Leu Leu Asp Ala Asp Phe Ser Val Asn Ala Gly Ser Trp 
                405                 410                 415     


Met Trp Leu Ser Cys Ser Ala Phe Phe Gln Gln Phe Phe His Cys Tyr 
            420                 425                 430         


Cys Pro Val Gly Phe Gly Arg Arg Thr Asp Pro Ser Gly Asp Tyr Ile 
        435                 440                 445             


Arg Arg Tyr Leu Pro Lys Leu Lys Ala Phe Pro Ser Arg Tyr Ile Tyr 
    450                 455                 460                 


Glu Pro Trp Asn Ala Pro Glu Ser Ile Gln Lys Ala Ala Lys Cys Ile 
465                 470                 475                 480 


Ile Gly Val Asp Tyr Pro Arg Pro Ile Val Asn His Ala Glu Thr Ser 
                485                 490                 495     


Arg Leu Asn Ile Glu Arg Met Lys Gln Ile Tyr Gln Gln Leu Ser Arg 
            500                 505                 510         


Tyr Arg Gly Leu Cys Leu Leu Ala Ser Val Pro Ser Cys Val Glu Asp 
        515                 520                 525             


Leu Ser His Pro Val Ala Glu Pro Ser Ser Ser Gln Ala Gly Ser Met 
    530                 535                 540                 


Ser Ser Ala Gly Pro Arg Pro Leu Pro Ser Gly Pro Ala Ser Pro Lys 
545                 550                 555                 560 


Arg Lys Leu Glu Ala Ala Glu Glu Pro Pro Gly Glu Glu Leu Ser Lys 
                565                 570                 575     


Arg Ala Arg Val Ala Glu Leu Pro Thr Pro Glu Leu Pro Ser Lys Asp 
            580                 585                 590         


Ala 
    


<210>  3557
<211>  614
<212>  PRT
<213>  Homo Sapiens

<400>  3557

Met Gly Gly Val His Val Ala Tyr Arg Gly Gly Ala Gly Val Ala Gly 
1               5                   10                  15      


Ala Val Trp Thr Val Met Ala Ala Thr Val Ala Thr Ala Ala Ala Val 
            20                  25                  30          


Ala Pro Ala Pro Ala Pro Gly Thr Asp Ser Ala Ser Ser Val His Trp 
        35                  40                  45              


Phe Arg Lys Gly Leu Arg Leu His Asp Asn Pro Ala Leu Leu Ala Ala 
    50                  55                  60                  


Val Arg Gly Ala Arg Cys Val Arg Cys Val Tyr Ile Leu Asp Pro Trp 
65                  70                  75                  80  


Phe Ala Ala Ser Ser Ser Val Gly Ile Asn Arg Trp Arg Phe Leu Leu 
                85                  90                  95      


Gln Ser Leu Glu Asp Leu Asp Thr Ser Leu Arg Lys Leu Asn Ser Arg 
            100                 105                 110         


Leu Phe Val Val Arg Gly Gln Pro Ala Asp Val Phe Pro Arg Leu Phe 
        115                 120                 125             


Lys Glu Trp Gly Val Thr Arg Leu Thr Phe Glu Tyr Asp Ser Glu Pro 
    130                 135                 140                 


Phe Gly Lys Glu Arg Asp Ala Ala Ile Met Lys Met Ala Lys Glu Ala 
145                 150                 155                 160 


Gly Val Glu Val Val Thr Glu Asn Ser His Thr Leu Tyr Asp Leu Asp 
                165                 170                 175     


Arg Ile Ile Glu Leu Asn Gly Gln Lys Pro Pro Leu Thr Tyr Lys Arg 
            180                 185                 190         


Phe Gln Ala Ile Ile Ser Arg Met Glu Leu Pro Lys Lys Pro Val Gly 
        195                 200                 205             


Leu Val Thr Ser Gln Gln Met Glu Ser Cys Arg Ala Glu Ile Gln Glu 
    210                 215                 220                 


Asn His Asp Glu Thr Tyr Gly Val Pro Ser Leu Glu Glu Leu Gly Phe 
225                 230                 235                 240 


Pro Thr Glu Gly Leu Gly Pro Ala Val Trp Gln Gly Gly Glu Thr Glu 
                245                 250                 255     


Ala Leu Ala Arg Leu Asp Lys His Leu Glu Arg Lys Ala Trp Val Ala 
            260                 265                 270         


Asn Tyr Glu Arg Pro Arg Met Asn Ala Asn Ser Leu Leu Ala Ser Pro 
        275                 280                 285             


Thr Gly Leu Ser Pro Tyr Leu Arg Phe Gly Cys Leu Ser Cys Arg Leu 
    290                 295                 300                 


Phe Tyr Tyr Arg Leu Trp Asp Leu Tyr Lys Lys Val Lys Arg Asn Ser 
305                 310                 315                 320 


Thr Pro Pro Leu Ser Leu Phe Gly Gln Leu Leu Trp Arg Glu Phe Phe 
                325                 330                 335     


Tyr Thr Ala Ala Thr Asn Asn Pro Arg Phe Asp Arg Met Glu Gly Asn 
            340                 345                 350         


Pro Ile Cys Ile Gln Ile Pro Trp Asp Arg Asn Pro Glu Ala Leu Ala 
        355                 360                 365             


Lys Trp Ala Glu Gly Lys Thr Gly Phe Pro Trp Ile Asp Ala Ile Met 
    370                 375                 380                 


Thr Gln Leu Arg Gln Glu Gly Trp Ile His His Leu Ala Arg His Ala 
385                 390                 395                 400 


Val Ala Cys Phe Leu Thr Arg Gly Asp Leu Trp Val Ser Trp Glu Ser 
                405                 410                 415     


Gly Val Arg Val Phe Asp Glu Leu Leu Leu Asp Ala Asp Phe Ser Val 
            420                 425                 430         


Asn Ala Gly Ser Trp Met Trp Leu Ser Cys Ser Ala Phe Phe Gln Gln 
        435                 440                 445             


Phe Phe His Cys Tyr Cys Pro Val Gly Phe Gly Arg Arg Thr Asp Pro 
    450                 455                 460                 


Ser Gly Asp Tyr Ile Arg Arg Tyr Leu Pro Lys Leu Lys Ala Phe Pro 
465                 470                 475                 480 


Ser Arg Tyr Ile Tyr Glu Pro Trp Asn Ala Pro Glu Ser Ile Gln Lys 
                485                 490                 495     


Ala Ala Lys Cys Ile Ile Gly Val Asp Tyr Pro Arg Pro Ile Val Asn 
            500                 505                 510         


His Ala Glu Thr Ser Arg Leu Asn Ile Glu Arg Met Lys Gln Ile Tyr 
        515                 520                 525             


Gln Gln Leu Ser Arg Tyr Arg Gly Leu Cys Leu Leu Ala Ser Val Pro 
    530                 535                 540                 


Ser Cys Val Glu Asp Leu Ser His Pro Val Ala Glu Pro Ser Ser Ser 
545                 550                 555                 560 


Gln Ala Gly Ser Met Ser Ser Ala Gly Pro Arg Pro Leu Pro Ser Gly 
                565                 570                 575     


Pro Ala Ser Pro Lys Arg Lys Leu Glu Ala Ala Glu Glu Pro Pro Gly 
            580                 585                 590         


Glu Glu Leu Ser Lys Arg Ala Arg Val Ala Glu Leu Pro Thr Pro Glu 
        595                 600                 605             


Leu Pro Ser Lys Asp Ala 
    610                 


<210>  3558
<211>  614
<212>  PRT
<213>  Homo Sapiens

<400>  3558

Met Gly Gly Val His Val Ala Tyr Arg Gly Gly Ala Gly Val Ala Gly 
1               5                   10                  15      


Ala Val Trp Thr Val Met Ala Ala Thr Val Ala Thr Ala Ala Ala Val 
            20                  25                  30          


Ala Pro Ala Pro Ala Pro Gly Thr Asp Ser Ala Ser Ser Val His Trp 
        35                  40                  45              


Phe Arg Lys Gly Leu Arg Leu His Asp Asn Pro Ala Leu Leu Ala Ala 
    50                  55                  60                  


Val Arg Gly Ala Arg Cys Val Arg Cys Val Tyr Ile Leu Asp Pro Trp 
65                  70                  75                  80  


Phe Ala Ala Ser Ser Ser Val Gly Ile Asn Arg Trp Arg Phe Leu Leu 
                85                  90                  95      


Gln Ser Leu Glu Asp Leu Asp Thr Ser Leu Arg Lys Leu Asn Ser Arg 
            100                 105                 110         


Leu Phe Val Val Arg Gly Gln Pro Ala Asp Val Phe Pro Arg Leu Phe 
        115                 120                 125             


Lys Glu Trp Gly Val Thr Arg Leu Thr Phe Glu Tyr Asp Ser Glu Pro 
    130                 135                 140                 


Phe Gly Lys Glu Arg Asp Ala Ala Ile Met Lys Met Ala Lys Glu Ala 
145                 150                 155                 160 


Gly Val Glu Val Val Thr Glu Asn Ser His Thr Leu Tyr Asp Leu Asp 
                165                 170                 175     


Arg Ile Ile Glu Leu Asn Gly Gln Lys Pro Pro Leu Thr Tyr Lys Arg 
            180                 185                 190         


Phe Gln Ala Ile Ile Ser Arg Met Glu Leu Pro Lys Lys Pro Val Gly 
        195                 200                 205             


Leu Val Thr Ser Gln Gln Met Glu Ser Cys Arg Ala Glu Ile Gln Glu 
    210                 215                 220                 


Asn His Asp Glu Thr Tyr Gly Val Pro Ser Leu Glu Glu Leu Gly Phe 
225                 230                 235                 240 


Pro Thr Glu Gly Leu Gly Pro Ala Val Trp Gln Gly Gly Glu Thr Glu 
                245                 250                 255     


Ala Leu Ala Arg Leu Asp Lys His Leu Glu Arg Lys Ala Trp Val Ala 
            260                 265                 270         


Asn Tyr Glu Arg Pro Arg Met Asn Ala Asn Ser Leu Leu Ala Ser Pro 
        275                 280                 285             


Thr Gly Leu Ser Pro Tyr Leu Arg Phe Gly Cys Leu Ser Cys Arg Leu 
    290                 295                 300                 


Phe Tyr Tyr Arg Leu Trp Asp Leu Tyr Lys Lys Val Lys Arg Asn Ser 
305                 310                 315                 320 


Thr Pro Pro Leu Ser Leu Phe Gly Gln Leu Leu Trp Arg Glu Phe Phe 
                325                 330                 335     


Tyr Thr Ala Ala Thr Asn Asn Pro Arg Phe Asp Arg Met Glu Gly Asn 
            340                 345                 350         


Pro Ile Cys Ile Gln Ile Pro Trp Asp Arg Asn Pro Glu Ala Leu Ala 
        355                 360                 365             


Lys Trp Ala Glu Gly Lys Thr Gly Phe Pro Trp Ile Asp Ala Ile Met 
    370                 375                 380                 


Thr Gln Leu Arg Gln Glu Gly Trp Ile His His Leu Ala Arg His Ala 
385                 390                 395                 400 


Val Ala Cys Phe Leu Thr Arg Gly Asp Leu Trp Val Ser Trp Glu Ser 
                405                 410                 415     


Gly Val Arg Val Phe Asp Glu Leu Leu Leu Asp Ala Asp Phe Ser Val 
            420                 425                 430         


Asn Ala Gly Ser Trp Met Trp Leu Ser Cys Ser Ala Phe Phe Gln Gln 
        435                 440                 445             


Phe Phe His Cys Tyr Cys Pro Val Gly Phe Gly Arg Arg Thr Asp Pro 
    450                 455                 460                 


Ser Gly Asp Tyr Ile Arg Arg Tyr Leu Pro Lys Leu Lys Ala Phe Pro 
465                 470                 475                 480 


Ser Arg Tyr Ile Tyr Glu Pro Trp Asn Ala Pro Glu Ser Ile Gln Lys 
                485                 490                 495     


Ala Ala Lys Cys Ile Ile Gly Val Asp Tyr Pro Arg Pro Ile Val Asn 
            500                 505                 510         


His Ala Glu Thr Ser Arg Leu Asn Ile Glu Arg Met Lys Gln Ile Tyr 
        515                 520                 525             


Gln Gln Leu Ser Arg Tyr Arg Gly Leu Cys Leu Leu Ala Ser Val Pro 
    530                 535                 540                 


Ser Cys Val Glu Asp Leu Ser His Pro Val Ala Glu Pro Ser Ser Ser 
545                 550                 555                 560 


Gln Ala Gly Ser Met Ser Ser Ala Gly Pro Arg Pro Leu Pro Ser Gly 
                565                 570                 575     


Pro Ala Ser Pro Lys Arg Lys Leu Glu Ala Ala Glu Glu Pro Pro Gly 
            580                 585                 590         


Glu Glu Leu Ser Lys Arg Ala Arg Val Ala Glu Leu Pro Thr Pro Glu 
        595                 600                 605             


Leu Pro Ser Lys Asp Ala 
    610                 


<210>  3559
<211>  532
<212>  PRT
<213>  Homo Sapiens

<400>  3559

Met Pro Ala Pro Pro Gly Arg Thr His Thr Trp Phe Leu Leu Gln Ser 
1               5                   10                  15      


Leu Glu Asp Leu Asp Thr Ser Leu Arg Lys Leu Asn Ser Arg Leu Phe 
            20                  25                  30          


Val Val Arg Gly Gln Pro Ala Asp Val Phe Pro Arg Leu Phe Lys Glu 
        35                  40                  45              


Trp Gly Val Thr Arg Leu Thr Phe Glu Tyr Asp Ser Glu Pro Phe Gly 
    50                  55                  60                  


Lys Glu Arg Asp Ala Ala Ile Met Lys Met Ala Lys Glu Ala Gly Val 
65                  70                  75                  80  


Glu Val Val Thr Glu Asn Ser His Thr Leu Tyr Asp Leu Asp Arg Ile 
                85                  90                  95      


Ile Glu Leu Asn Gly Gln Lys Pro Pro Leu Thr Tyr Lys Arg Phe Gln 
            100                 105                 110         


Ala Ile Ile Ser Arg Met Glu Leu Pro Lys Lys Pro Val Gly Leu Val 
        115                 120                 125             


Thr Ser Gln Gln Met Glu Ser Cys Arg Ala Glu Ile Gln Glu Asn His 
    130                 135                 140                 


Asp Glu Thr Tyr Gly Val Pro Ser Leu Glu Glu Leu Gly Phe Pro Thr 
145                 150                 155                 160 


Glu Gly Leu Gly Pro Ala Val Trp Gln Gly Gly Glu Thr Glu Ala Leu 
                165                 170                 175     


Ala Arg Leu Asp Lys His Leu Glu Arg Lys Ala Trp Val Ala Asn Tyr 
            180                 185                 190         


Glu Arg Pro Arg Met Asn Ala Asn Ser Leu Leu Ala Ser Pro Thr Gly 
        195                 200                 205             


Leu Ser Pro Tyr Leu Arg Phe Gly Cys Leu Ser Cys Arg Leu Phe Tyr 
    210                 215                 220                 


Tyr Arg Leu Trp Asp Leu Tyr Lys Lys Val Lys Arg Asn Ser Thr Pro 
225                 230                 235                 240 


Pro Leu Ser Leu Phe Gly Gln Leu Leu Trp Arg Glu Phe Phe Tyr Thr 
                245                 250                 255     


Ala Ala Thr Asn Asn Pro Arg Phe Asp Arg Met Glu Gly Asn Pro Ile 
            260                 265                 270         


Cys Ile Gln Ile Pro Trp Asp Arg Asn Pro Glu Ala Leu Ala Lys Trp 
        275                 280                 285             


Ala Glu Gly Lys Thr Gly Phe Pro Trp Ile Asp Ala Ile Met Thr Gln 
    290                 295                 300                 


Leu Arg Gln Glu Gly Trp Ile His His Leu Ala Arg His Ala Val Ala 
305                 310                 315                 320 


Cys Phe Leu Thr Arg Gly Asp Leu Trp Val Ser Trp Glu Ser Gly Val 
                325                 330                 335     


Arg Val Phe Asp Glu Leu Leu Leu Asp Ala Asp Phe Ser Val Asn Ala 
            340                 345                 350         


Gly Ser Trp Met Trp Leu Ser Cys Ser Ala Phe Phe Gln Gln Phe Phe 
        355                 360                 365             


His Cys Tyr Cys Pro Val Gly Phe Gly Arg Arg Thr Asp Pro Ser Gly 
    370                 375                 380                 


Asp Tyr Ile Arg Arg Tyr Leu Pro Lys Leu Lys Ala Phe Pro Ser Arg 
385                 390                 395                 400 


Tyr Ile Tyr Glu Pro Trp Asn Ala Pro Glu Ser Ile Gln Lys Ala Ala 
                405                 410                 415     


Lys Cys Ile Ile Gly Val Asp Tyr Pro Arg Pro Ile Val Asn His Ala 
            420                 425                 430         


Glu Thr Ser Arg Leu Asn Ile Glu Arg Met Lys Gln Ile Tyr Gln Gln 
        435                 440                 445             


Leu Ser Arg Tyr Arg Gly Leu Cys Leu Leu Ala Ser Val Pro Ser Cys 
    450                 455                 460                 


Val Glu Asp Leu Ser His Pro Val Ala Glu Pro Ser Ser Ser Gln Ala 
465                 470                 475                 480 


Gly Ser Met Ser Ser Ala Gly Pro Arg Pro Leu Pro Ser Gly Pro Ala 
                485                 490                 495     


Ser Pro Lys Arg Lys Leu Glu Ala Ala Glu Glu Pro Pro Gly Glu Glu 
            500                 505                 510         


Leu Ser Lys Arg Ala Arg Val Ala Glu Leu Pro Thr Pro Glu Leu Pro 
        515                 520                 525             


Ser Lys Asp Ala 
    530         


<210>  3560
<211>  142
<212>  PRT
<213>  Homo Sapiens

<400>  3560

Ile Gln Lys Gly Thr Ser Val Ser Gln Lys Val Cys Glu Trp Lys Glu 
1               5                   10                  15      


Pro Glu Glu Leu Lys Gln Leu Leu Asp Leu Glu Leu Arg Ser Gln Gly 
            20                  25                  30          


Glu Ser Gln Lys Gln Ile Leu Glu Arg Cys Arg Ala Val Ile Arg Tyr 
        35                  40                  45              


Ser Val Lys Thr Gly His Pro Arg Phe Phe Asn Gln Leu Phe Ser Gly 
    50                  55                  60                  


Leu Asp Pro His Ala Leu Ala Gly Arg Ile Ile Thr Glu Ser Leu Asn 
65                  70                  75                  80  


Thr Ser Gln Tyr Thr Tyr Glu Ile Ala Pro Val Phe Val Leu Met Glu 
                85                  90                  95      


Glu Glu Val Leu Arg Lys Leu Arg Ala Leu Val Gly Trp Ser Ser Gly 
            100                 105                 110         


Asp Gly Ile Phe Cys Pro Val Ser Leu Leu His Pro Glu Gly Ser Cys 
        115                 120                 125             


Val Ser Gly Thr Trp His Arg Gln Cys Pro Ser Gly Gln Gly 
    130                 135                 140         


<210>  3561
<211>  135
<212>  PRT
<213>  Homo Sapiens

<400>  3561

Met Ala Asp Ser Glu Ala Leu Pro Ser Leu Ala Gly Asp Pro Val Ala 
1               5                   10                  15      


Val Glu Ala Leu Leu Arg Ala Val Phe Gly Val Val Val Asp Glu Ala 
            20                  25                  30          


Ile Gln Lys Gly Thr Ser Val Ser Gln Lys Cys His Tyr Ser Ile Gln 
        35                  40                  45              


Lys Gly Ala Ala Phe Leu Gly Leu Gly Thr Asp Ser Val Arg Val Val 
    50                  55                  60                  


Lys Ala Asp Glu Arg Gly Lys Met Val Pro Glu Asp Leu Glu Arg Gln 
65                  70                  75                  80  


Ile Gly Met Ala Glu Ala Glu Gly Ala Val Pro Phe Leu Val Ser Ala 
                85                  90                  95      


Thr Ser Gly Thr Thr Val Leu Gly Ala Phe Asp Pro Leu Glu Ala Ile 
            100                 105                 110         


Ala Asp Val Cys Gln Arg His Gly Leu Trp Leu His Val Asp Ala Ala 
        115                 120                 125             


Trp Gly Gly Ser Val Leu Leu 
    130                 135 


<210>  3562
<211>  346
<212>  PRT
<213>  Homo Sapiens

<400>  3562

Met Ala Asp Ser Glu Ala Leu Pro Ser Leu Ala Gly Asp Pro Val Ala 
1               5                   10                  15      


Val Glu Ala Leu Leu Arg Ala Val Phe Gly Val Val Val Asp Glu Ala 
            20                  25                  30          


Ile Gln Lys Gly Thr Ser Val Ser Gln Lys Cys His Tyr Ser Ile Gln 
        35                  40                  45              


Lys Gly Ala Ala Phe Leu Gly Leu Gly Thr Asp Ser Val Arg Val Val 
    50                  55                  60                  


Lys Ala Asp Glu Arg Gly Lys Met Val Pro Glu Asp Leu Glu Arg Gln 
65                  70                  75                  80  


Ile Gly Met Ala Glu Ala Glu Gly Ala Val Pro Phe Leu Val Ser Ala 
                85                  90                  95      


Thr Ser Gly Thr Thr Val Leu Gly Ala Phe Asp Pro Leu Glu Ala Ile 
            100                 105                 110         


Ala Asp Val Cys Gln Arg His Gly Leu Trp Leu His Val Asp Ala Ala 
        115                 120                 125             


Trp Gly Gly Ser Val Leu Leu Ser Gln Thr His Arg His Leu Leu Asp 
    130                 135                 140                 


Gly Ile Gln Arg Ala Asp Ser Val Ala Trp Asn Pro His Lys Leu Leu 
145                 150                 155                 160 


Ala Ala Gly Leu Gln Cys Ser Ala Leu Leu Leu Gln Asp Thr Ser Asn 
                165                 170                 175     


Leu Leu Lys Arg Cys His Gly Ser Gln Ala Ser Tyr Leu Phe Gln Gln 
            180                 185                 190         


Asp Lys Phe Tyr Asp Val Ala Leu Asp Thr Gly Asp Lys Val Val Gln 
        195                 200                 205             


Cys Gly Arg Arg Val Asp Cys Leu Lys Leu Trp Leu Met Trp Lys Ala 
    210                 215                 220                 


Gln Gly Asp Gln Gly Leu Glu Arg Arg Ile Asp Gln Ala Phe Val Leu 
225                 230                 235                 240 


Ala Arg Tyr Leu Val Glu Glu Met Lys Lys Arg Glu Gly Phe Glu Leu 
                245                 250                 255     


Val Met Glu Pro Glu Phe Val Asn Val Cys Phe Trp Phe Val Pro Pro 
            260                 265                 270         


Ser Leu Arg Gly Lys Gln Glu Ser Pro Asp Tyr His Glu Arg Leu Ser 
        275                 280                 285             


Lys Val Ala Pro Val Leu Lys Glu Arg Met Val Lys Glu Gly Ser Met 
    290                 295                 300                 


Met Ile Gly Tyr Gln Pro His Gly Thr Arg Gly Asn Phe Phe Arg Val 
305                 310                 315                 320 


Val Val Ala Asn Ser Ala Leu Thr Cys Ala Asp Met Asp Phe Leu Leu 
                325                 330                 335     


Asn Glu Leu Glu Arg Leu Gly Gln Asp Leu 
            340                 345     


<210>  3563
<211>  129
<212>  PRT
<213>  Homo Sapiens

<400>  3563

Met Ala Asp Ser Glu Ala Leu Pro Ser Leu Ala Gly Asp Pro Val Ala 
1               5                   10                  15      


Val Glu Ala Leu Leu Arg Ala Val Phe Gly Val Val Val Asp Glu Ala 
            20                  25                  30          


Ile Gln Lys Gly Thr Ser Val Ser Gln Lys Val Cys Glu Trp Lys Glu 
        35                  40                  45              


Pro Glu Glu Leu Lys Gln Leu Leu Asp Leu Glu Leu Arg Ser Gln Gly 
    50                  55                  60                  


Glu Ser Gln Lys Gln Ile Leu Glu Arg Cys Arg Ala Val Ile Arg Tyr 
65                  70                  75                  80  


Ser Val Lys Thr Gly His Pro Arg Phe Phe Asn Gln Leu Phe Ser Gly 
                85                  90                  95      


Leu Asp Pro His Ala Leu Ala Gly Arg Ile Ile Thr Glu Ser Leu Asn 
            100                 105                 110         


Thr Ser Gln Tyr Thr Tyr Glu Ile Ala Pro Val Phe Val Leu Met Glu 
        115                 120                 125             


Glu 
    


<210>  3564
<211>  146
<212>  PRT
<213>  Homo Sapiens

<400>  3564

Met Ala Asp Ser Glu Ala Leu Pro Ser Leu Ala Gly Asp Pro Val Ala 
1               5                   10                  15      


Val Glu Ala Leu Leu Arg Ala Val Phe Gly Val Val Val Asp Glu Ala 
            20                  25                  30          


Ile Gln Lys Gly Thr Ser Val Ser Gln Lys Val Cys Glu Trp Lys Glu 
        35                  40                  45              


Pro Glu Glu Leu Lys Gln Leu Leu Asp Leu Glu Leu Arg Ser Gln Gly 
    50                  55                  60                  


Glu Ser Gln Lys Gln Ile Leu Glu Arg Cys Arg Ala Val Ile Arg Tyr 
65                  70                  75                  80  


Ser Val Lys Thr Gly His Pro Arg Phe Phe Asn Gln Leu Phe Ser Gly 
                85                  90                  95      


Leu Asp Pro His Ala Leu Ala Gly Arg Ile Ile Thr Glu Ser Leu Asn 
            100                 105                 110         


Thr Ser Gln Tyr Thr Tyr Glu Ile Ala Pro Val Phe Val Leu Met Glu 
        115                 120                 125             


Glu Glu Val Leu Arg Lys Leu Arg Ala Leu Val Gly Trp Ser Ser Gly 
    130                 135                 140                 


Asp Gly 
145     


<210>  3565
<211>  163
<212>  PRT
<213>  Homo Sapiens

<400>  3565

Met Ala Asp Ser Glu Ala Leu Pro Ser Leu Ala Gly Asp Pro Val Ala 
1               5                   10                  15      


Val Glu Ala Leu Leu Arg Ala Val Phe Gly Val Val Val Asp Glu Ala 
            20                  25                  30          


Ile Gln Lys Gly Thr Ser Val Ser Gln Lys Val Cys Glu Trp Lys Glu 
        35                  40                  45              


Pro Glu Glu Leu Lys Gln Leu Leu Asp Leu Glu Leu Arg Ser Gln Gly 
    50                  55                  60                  


Glu Ser Gln Lys Gln Ile Leu Glu Arg Cys Arg Ala Val Ile Arg Tyr 
65                  70                  75                  80  


Ser Val Lys Thr Gly His Pro Arg Phe Phe Asn Gln Leu Phe Ser Gly 
                85                  90                  95      


Leu Asp Pro His Ala Leu Ala Gly Arg Ile Ile Thr Glu Ser Leu Asn 
            100                 105                 110         


Thr Ser Gln Tyr Thr Tyr Glu Ile Ala Pro Val Phe Val Leu Met Glu 
        115                 120                 125             


Glu Glu Val Leu Arg Lys Leu Arg Ala Leu Val Gly Trp Ser Ser Gly 
    130                 135                 140                 


Asp Gly Ile Phe Cys Pro Gly Gly Ser Ile Ser Asn Met Tyr Ala Val 
145                 150                 155                 160 


Asn Leu Ala 
            


<210>  3566
<211>  493
<212>  PRT
<213>  Homo Sapiens

<400>  3566

Met Ala Asp Ser Glu Ala Leu Pro Ser Leu Ala Gly Asp Pro Val Ala 
1               5                   10                  15      


Val Glu Ala Leu Leu Arg Ala Val Phe Gly Val Val Val Asp Glu Ala 
            20                  25                  30          


Ile Gln Lys Gly Thr Ser Val Ser Gln Lys Val Cys Glu Trp Lys Glu 
        35                  40                  45              


Pro Glu Glu Leu Lys Gln Leu Leu Asp Leu Glu Leu Arg Ser Gln Gly 
    50                  55                  60                  


Glu Ser Gln Lys Gln Ile Leu Glu Arg Cys Arg Ala Val Ile Arg Tyr 
65                  70                  75                  80  


Ser Val Lys Thr Gly His Pro Arg Phe Phe Asn Gln Leu Phe Ser Gly 
                85                  90                  95      


Leu Asp Pro His Ala Leu Ala Gly Arg Ile Ile Thr Glu Ser Leu Asn 
            100                 105                 110         


Thr Ser Gln Tyr Thr Tyr Glu Ile Ala Pro Val Phe Val Leu Met Glu 
        115                 120                 125             


Glu Glu Val Leu Arg Lys Leu Arg Ala Leu Val Gly Trp Ser Ser Gly 
    130                 135                 140                 


Asp Gly Ile Phe Cys Pro Gly Gly Ser Ile Ser Asn Met Tyr Ala Val 
145                 150                 155                 160 


Asn Leu Ala Arg Tyr Gln Arg Tyr Pro Asp Cys Lys Gln Arg Gly Leu 
                165                 170                 175     


Arg Thr Leu Pro Pro Leu Ala Leu Phe Thr Ser Lys Glu Cys His Tyr 
            180                 185                 190         


Ser Ile Gln Lys Gly Ala Ala Phe Leu Gly Leu Gly Thr Asp Ser Val 
        195                 200                 205             


Arg Val Val Lys Ala Asp Glu Arg Gly Lys Met Val Pro Glu Asp Leu 
    210                 215                 220                 


Glu Arg Gln Ile Gly Met Ala Glu Ala Glu Gly Ala Val Pro Phe Leu 
225                 230                 235                 240 


Val Ser Ala Thr Ser Gly Thr Thr Val Leu Gly Ala Phe Asp Pro Leu 
                245                 250                 255     


Glu Ala Ile Ala Asp Val Cys Gln Arg His Gly Leu Trp Leu His Val 
            260                 265                 270         


Asp Ala Ala Trp Gly Gly Ser Val Leu Leu Ser Gln Thr His Arg His 
        275                 280                 285             


Leu Leu Asp Gly Ile Gln Arg Ala Asp Ser Val Ala Trp Asn Pro His 
    290                 295                 300                 


Lys Leu Leu Ala Ala Gly Leu Gln Cys Ser Ala Leu Leu Leu Gln Asp 
305                 310                 315                 320 


Thr Ser Asn Leu Leu Lys Arg Cys His Gly Ser Gln Ala Ser Tyr Leu 
                325                 330                 335     


Phe Gln Gln Asp Lys Phe Tyr Asp Val Ala Leu Asp Thr Gly Asp Lys 
            340                 345                 350         


Val Val Gln Cys Gly Arg Arg Val Asp Cys Leu Lys Leu Trp Leu Met 
        355                 360                 365             


Trp Lys Ala Gln Gly Asp Gln Gly Leu Glu Arg Arg Ile Asp Gln Ala 
    370                 375                 380                 


Phe Val Leu Ala Arg Tyr Leu Val Glu Glu Met Lys Lys Arg Glu Gly 
385                 390                 395                 400 


Phe Glu Leu Val Met Glu Pro Glu Phe Val Asn Val Cys Phe Trp Phe 
                405                 410                 415     


Val Pro Pro Ser Leu Arg Gly Lys Gln Glu Ser Pro Asp Tyr His Glu 
            420                 425                 430         


Arg Leu Ser Lys Val Ala Pro Val Leu Lys Glu Arg Met Val Lys Glu 
        435                 440                 445             


Gly Ser Met Met Ile Gly Tyr Gln Pro His Gly Thr Arg Gly Asn Phe 
    450                 455                 460                 


Phe Arg Val Val Val Ala Asn Ser Ala Leu Thr Cys Ala Asp Met Asp 
465                 470                 475                 480 


Phe Leu Leu Asn Glu Leu Glu Arg Leu Gly Gln Asp Leu 
                485                 490             


<210>  3567
<211>  493
<212>  PRT
<213>  Homo Sapiens

<400>  3567

Met Ala Asp Ser Glu Ala Leu Pro Ser Leu Ala Gly Asp Pro Val Ala 
1               5                   10                  15      


Val Glu Ala Leu Leu Arg Ala Val Phe Gly Val Val Val Asp Glu Ala 
            20                  25                  30          


Ile Gln Lys Gly Thr Ser Val Ser Gln Lys Val Cys Glu Trp Lys Glu 
        35                  40                  45              


Pro Glu Glu Leu Lys Gln Leu Leu Asp Leu Glu Leu Arg Ser Gln Gly 
    50                  55                  60                  


Glu Ser Gln Lys Gln Ile Leu Glu Arg Cys Arg Ala Val Ile Arg Tyr 
65                  70                  75                  80  


Ser Val Lys Thr Gly His Pro Arg Phe Phe Asn Gln Leu Phe Ser Gly 
                85                  90                  95      


Leu Asp Pro His Ala Leu Ala Gly Arg Ile Ile Thr Glu Ser Leu Asn 
            100                 105                 110         


Thr Ser Gln Tyr Thr Tyr Glu Ile Ala Pro Val Phe Val Leu Met Glu 
        115                 120                 125             


Glu Glu Val Leu Arg Lys Leu Arg Ala Leu Val Gly Trp Ser Ser Gly 
    130                 135                 140                 


Asp Gly Ile Phe Cys Pro Gly Gly Ser Ile Ser Asn Met Tyr Ala Val 
145                 150                 155                 160 


Asn Leu Ala Arg Tyr Gln Arg Tyr Pro Asp Cys Lys Gln Arg Gly Leu 
                165                 170                 175     


Arg Thr Leu Pro Pro Leu Ala Leu Phe Thr Ser Lys Glu Cys His Tyr 
            180                 185                 190         


Ser Ile Gln Lys Gly Ala Ala Phe Leu Gly Leu Gly Thr Asp Ser Val 
        195                 200                 205             


Arg Val Val Lys Ala Asp Glu Arg Gly Lys Met Val Pro Glu Asp Leu 
    210                 215                 220                 


Glu Arg Gln Ile Gly Met Ala Glu Ala Glu Gly Ala Val Pro Phe Leu 
225                 230                 235                 240 


Val Ser Ala Thr Ser Gly Thr Thr Val Leu Gly Ala Phe Asp Pro Leu 
                245                 250                 255     


Glu Ala Ile Ala Asp Val Cys Gln Arg His Gly Leu Trp Leu His Val 
            260                 265                 270         


Asp Ala Ala Trp Gly Gly Ser Val Leu Leu Ser Gln Thr His Arg His 
        275                 280                 285             


Leu Leu Asp Gly Ile Gln Arg Ala Asp Ser Val Ala Trp Asn Pro His 
    290                 295                 300                 


Lys Leu Leu Ala Ala Gly Leu Gln Cys Ser Ala Leu Leu Leu Gln Asp 
305                 310                 315                 320 


Thr Ser Asn Leu Leu Lys Arg Cys His Gly Ser Gln Ala Ser Tyr Leu 
                325                 330                 335     


Phe Gln Gln Asp Lys Phe Tyr Asp Val Ala Leu Asp Thr Gly Asp Lys 
            340                 345                 350         


Val Val Gln Cys Gly Arg Arg Val Asp Cys Leu Lys Leu Trp Leu Met 
        355                 360                 365             


Trp Lys Ala Gln Gly Asp Gln Gly Leu Glu Arg Arg Ile Asp Gln Ala 
    370                 375                 380                 


Phe Val Leu Ala Arg Tyr Leu Val Glu Glu Met Lys Lys Arg Glu Gly 
385                 390                 395                 400 


Phe Glu Leu Val Met Glu Pro Glu Phe Val Asn Val Cys Phe Trp Phe 
                405                 410                 415     


Val Pro Pro Ser Leu Arg Gly Lys Gln Glu Ser Pro Asp Tyr His Glu 
            420                 425                 430         


Arg Leu Ser Lys Val Ala Pro Val Leu Lys Glu Arg Met Val Lys Glu 
        435                 440                 445             


Gly Ser Met Met Ile Gly Tyr Gln Pro His Gly Thr Arg Gly Asn Phe 
    450                 455                 460                 


Phe Arg Val Val Val Ala Asn Ser Ala Leu Thr Cys Ala Asp Met Asp 
465                 470                 475                 480 


Phe Leu Leu Asn Glu Leu Glu Arg Leu Gly Gln Asp Leu 
                485                 490             


<210>  3568
<211>  267
<212>  PRT
<213>  Homo Sapiens

<400>  3568

Met Ala Asp Ser Glu Ala Leu Pro Ser Leu Ala Gly Asp Pro Val Ala 
1               5                   10                  15      


Val Glu Ala Leu Leu Arg Ala Val Phe Gly Val Val Val Asp Glu Ala 
            20                  25                  30          


Ile Gln Lys Gly Thr Ser Val Ser Gln Lys Val Cys Glu Trp Lys Glu 
        35                  40                  45              


Pro Glu Glu Leu Lys Gln Leu Leu Asp Leu Glu Leu Arg Ser Gln Gly 
    50                  55                  60                  


Glu Ser Gln Lys Gln Ile Leu Glu Arg Cys Arg Ala Val Ile Arg Tyr 
65                  70                  75                  80  


Ser Val Lys Thr Gly His Pro Arg Phe Phe Asn Gln Leu Phe Ser Gly 
                85                  90                  95      


Leu Asp Pro His Ala Leu Ala Gly Arg Ile Ile Thr Glu Ser Leu Asn 
            100                 105                 110         


Thr Ser Gln Tyr Thr Tyr Glu Ile Ala Pro Val Phe Val Leu Met Glu 
        115                 120                 125             


Glu Glu Val Leu Arg Lys Leu Arg Ala Leu Val Gly Trp Ser Ser Gly 
    130                 135                 140                 


Asp Gly Ile Phe Cys Pro Gly Gly Ser Ile Ser Asn Met Tyr Ala Val 
145                 150                 155                 160 


Asn Leu Ala Arg Tyr Gln Arg Tyr Pro Asp Cys Lys Gln Arg Gly Leu 
                165                 170                 175     


Arg Thr Leu Pro Pro Leu Ala Leu Phe Thr Ser Lys Glu Val Gly Lys 
            180                 185                 190         


Arg His Arg Pro Asn Pro Gly Leu Leu Ile Leu Ile Ser Ser His Val 
        195                 200                 205             


Thr Thr Pro Ser Arg Arg Glu Leu Arg Phe Trp Asp Leu Ala Pro Thr 
    210                 215                 220                 


Val Ser Glu Trp Ser Arg Leu Met Arg Glu Gly Lys Trp Ser Pro Arg 
225                 230                 235                 240 


Ile Trp Arg Gly Arg Leu Val Trp Pro Arg Leu Arg Val Leu Cys Arg 
                245                 250                 255     


Ser Trp Ser Val Pro Pro Leu Ala Pro Leu Cys 
            260                 265         


<210>  3569
<211>  267
<212>  PRT
<213>  Homo Sapiens

<400>  3569

Met Ala Asp Ser Glu Ala Leu Pro Ser Leu Ala Gly Asp Pro Val Ala 
1               5                   10                  15      


Val Glu Ala Leu Leu Arg Ala Val Phe Gly Val Val Val Asp Glu Ala 
            20                  25                  30          


Ile Gln Lys Gly Thr Ser Val Ser Gln Lys Val Cys Glu Trp Lys Glu 
        35                  40                  45              


Pro Glu Glu Leu Lys Gln Leu Leu Asp Leu Glu Leu Arg Ser Gln Gly 
    50                  55                  60                  


Glu Ser Gln Lys Gln Ile Leu Glu Arg Cys Arg Ala Val Ile Arg Tyr 
65                  70                  75                  80  


Ser Val Lys Thr Gly His Pro Arg Phe Phe Asn Gln Leu Phe Ser Gly 
                85                  90                  95      


Leu Asp Pro His Ala Leu Ala Gly Arg Ile Ile Thr Glu Ser Leu Asn 
            100                 105                 110         


Thr Ser Gln Tyr Thr Tyr Glu Ile Ala Pro Val Phe Val Leu Met Glu 
        115                 120                 125             


Glu Glu Val Leu Arg Lys Leu Arg Ala Leu Val Gly Trp Ser Ser Gly 
    130                 135                 140                 


Asp Gly Ile Phe Cys Pro Gly Gly Ser Ile Ser Asn Met Tyr Ala Val 
145                 150                 155                 160 


Asn Leu Ala Arg Tyr Gln Arg Tyr Pro Asp Cys Lys Gln Arg Gly Leu 
                165                 170                 175     


Arg Thr Leu Pro Pro Leu Ala Leu Phe Thr Ser Lys Glu Val Gly Lys 
            180                 185                 190         


Arg His Arg Pro Asn Pro Gly Leu Leu Ile Leu Ile Ser Ser His Val 
        195                 200                 205             


Thr Thr Pro Ser Arg Arg Glu Leu Arg Phe Trp Asp Leu Ala Pro Thr 
    210                 215                 220                 


Val Ser Glu Trp Ser Arg Leu Met Arg Glu Gly Lys Trp Ser Pro Arg 
225                 230                 235                 240 


Ile Trp Arg Gly Arg Leu Val Trp Pro Arg Leu Arg Val Leu Cys Arg 
                245                 250                 255     


Ser Trp Ser Val Pro Pro Leu Ala Pro Leu Cys 
            260                 265         


<210>  3570
<211>  45
<212>  PRT
<213>  Homo Sapiens

<400>  3570

Met Ala Asp Ser Glu Ala Leu Pro Ser Leu Ala Gly Asp Pro Val Ala 
1               5                   10                  15      


Val Glu Ala Leu Leu Arg Ala Val Phe Gly Val Val Val Asp Glu Ala 
            20                  25                  30          


Ile Gln Lys Gly Thr Ser Val Ser Gln Lys Val His Ile 
        35                  40                  45  


<210>  3571
<211>  520
<212>  PRT
<213>  Homo Sapiens

<400>  3571

Met Ser Ile Pro Leu Lys Ser Ser Phe Leu Leu Ser Tyr Leu Cys Thr 
1               5                   10                  15      


Leu Pro Pro Ala Leu Leu Ser Arg Glu Ile Leu Met Ala Asp Ser Glu 
            20                  25                  30          


Ala Leu Pro Ser Leu Ala Gly Asp Pro Val Ala Val Glu Ala Leu Leu 
        35                  40                  45              


Arg Ala Val Phe Gly Val Val Val Asp Glu Ala Ile Gln Lys Gly Thr 
    50                  55                  60                  


Ser Val Ser Gln Lys Val Cys Glu Trp Lys Glu Pro Glu Glu Leu Lys 
65                  70                  75                  80  


Gln Leu Leu Asp Leu Glu Leu Arg Ser Gln Gly Glu Ser Gln Lys Gln 
                85                  90                  95      


Ile Leu Glu Arg Cys Arg Ala Val Ile Arg Tyr Ser Val Lys Thr Gly 
            100                 105                 110         


His Pro Arg Phe Phe Asn Gln Leu Phe Ser Gly Leu Asp Pro His Ala 
        115                 120                 125             


Leu Ala Gly Arg Ile Ile Thr Glu Ser Leu Asn Thr Ser Gln Tyr Thr 
    130                 135                 140                 


Tyr Glu Ile Ala Pro Val Phe Val Leu Met Glu Glu Glu Val Leu Arg 
145                 150                 155                 160 


Lys Leu Arg Ala Leu Val Gly Trp Ser Ser Gly Asp Gly Ile Phe Cys 
                165                 170                 175     


Pro Gly Gly Ser Ile Ser Asn Met Tyr Ala Val Asn Leu Ala Arg Tyr 
            180                 185                 190         


Gln Arg Tyr Pro Asp Cys Lys Gln Arg Gly Leu Arg Thr Leu Pro Pro 
        195                 200                 205             


Leu Ala Leu Phe Thr Ser Lys Glu Cys His Tyr Ser Ile Gln Lys Gly 
    210                 215                 220                 


Ala Ala Phe Leu Gly Leu Gly Thr Asp Ser Val Arg Val Val Lys Ala 
225                 230                 235                 240 


Asp Glu Arg Gly Lys Met Val Pro Glu Asp Leu Glu Arg Gln Ile Gly 
                245                 250                 255     


Met Ala Glu Ala Glu Gly Ala Val Pro Phe Leu Val Ser Ala Thr Ser 
            260                 265                 270         


Gly Thr Thr Val Leu Gly Ala Phe Asp Pro Leu Glu Ala Ile Ala Asp 
        275                 280                 285             


Val Cys Gln Arg His Gly Leu Trp Leu His Val Asp Ala Ala Trp Gly 
    290                 295                 300                 


Gly Ser Val Leu Leu Ser Gln Thr His Arg His Leu Leu Asp Gly Ile 
305                 310                 315                 320 


Gln Arg Ala Asp Ser Val Ala Trp Asn Pro His Lys Leu Leu Ala Ala 
                325                 330                 335     


Gly Leu Gln Cys Ser Ala Leu Leu Leu Gln Asp Thr Ser Asn Leu Leu 
            340                 345                 350         


Lys Arg Cys His Gly Ser Gln Ala Ser Tyr Leu Phe Gln Gln Asp Lys 
        355                 360                 365             


Phe Tyr Asp Val Ala Leu Asp Thr Gly Asp Lys Val Val Gln Cys Gly 
    370                 375                 380                 


Arg Arg Val Asp Cys Leu Lys Leu Trp Leu Met Trp Lys Ala Gln Gly 
385                 390                 395                 400 


Asp Gln Gly Leu Glu Arg Arg Ile Asp Gln Ala Phe Val Leu Ala Arg 
                405                 410                 415     


Tyr Leu Val Glu Glu Met Lys Lys Arg Glu Gly Phe Glu Leu Val Met 
            420                 425                 430         


Glu Pro Glu Phe Val Asn Val Cys Phe Trp Phe Val Pro Pro Ser Leu 
        435                 440                 445             


Arg Gly Lys Gln Glu Ser Pro Asp Tyr His Glu Arg Leu Ser Lys Val 
    450                 455                 460                 


Ala Pro Val Leu Lys Glu Arg Met Val Lys Glu Gly Ser Met Met Ile 
465                 470                 475                 480 


Gly Tyr Gln Pro His Gly Thr Arg Gly Asn Phe Phe Arg Val Val Val 
                485                 490                 495     


Ala Asn Ser Ala Leu Thr Cys Ala Asp Met Asp Phe Leu Leu Asn Glu 
            500                 505                 510         


Leu Glu Arg Leu Gly Gln Asp Leu 
        515                 520 


<210>  3572
<211>  519
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3572

Xaa Leu Gly Asp Ala Arg Arg Gly Ala Ala Gly Tyr Leu Cys Thr Leu 
1               5                   10                  15      


Pro Pro Ala Leu Leu Ser Arg Glu Ile Leu Met Ala Asp Ser Glu Ala 
            20                  25                  30          


Leu Pro Ser Leu Ala Gly Asp Pro Val Ala Val Glu Ala Leu Leu Arg 
        35                  40                  45              


Ala Val Phe Gly Val Val Val Asp Glu Ala Ile Gln Lys Gly Thr Ser 
    50                  55                  60                  


Val Ser Gln Lys Val Cys Glu Trp Lys Glu Pro Glu Glu Leu Lys Gln 
65                  70                  75                  80  


Leu Leu Asp Leu Glu Leu Arg Ser Gln Gly Glu Ser Gln Lys Gln Ile 
                85                  90                  95      


Leu Glu Arg Cys Arg Ala Val Ile Arg Tyr Ser Val Lys Thr Gly His 
            100                 105                 110         


Pro Arg Phe Phe Asn Gln Leu Phe Ser Gly Leu Asp Pro His Ala Leu 
        115                 120                 125             


Ala Gly Arg Ile Ile Thr Glu Ser Leu Asn Thr Ser Gln Tyr Thr Tyr 
    130                 135                 140                 


Glu Ile Ala Pro Val Phe Val Leu Met Glu Glu Glu Val Leu Arg Lys 
145                 150                 155                 160 


Leu Arg Ala Leu Val Gly Trp Ser Ser Gly Asp Gly Ile Phe Cys Pro 
                165                 170                 175     


Gly Gly Ser Ile Ser Asn Met Tyr Ala Val Asn Leu Ala Arg Tyr Gln 
            180                 185                 190         


Arg Tyr Pro Asp Cys Lys Gln Arg Gly Leu Arg Thr Leu Pro Pro Leu 
        195                 200                 205             


Ala Leu Phe Thr Ser Lys Glu Cys His Tyr Ser Ile Gln Lys Gly Ala 
    210                 215                 220                 


Ala Phe Leu Gly Leu Gly Thr Asp Ser Val Arg Val Val Lys Ala Asp 
225                 230                 235                 240 


Glu Arg Gly Lys Met Val Pro Glu Asp Leu Glu Arg Gln Ile Gly Met 
                245                 250                 255     


Ala Glu Ala Glu Gly Ala Val Pro Phe Leu Val Ser Ala Thr Ser Gly 
            260                 265                 270         


Thr Thr Val Leu Gly Ala Phe Asp Pro Leu Glu Ala Ile Ala Asp Val 
        275                 280                 285             


Cys Gln Arg His Gly Leu Trp Leu His Val Asp Ala Ala Trp Gly Gly 
    290                 295                 300                 


Ser Val Leu Leu Ser Gln Thr His Arg His Leu Leu Asp Gly Ile Gln 
305                 310                 315                 320 


Arg Ala Asp Ser Val Ala Trp Asn Pro His Lys Leu Leu Ala Ala Gly 
                325                 330                 335     


Leu Gln Cys Ser Ala Leu Leu Leu Gln Asp Thr Ser Asn Leu Leu Lys 
            340                 345                 350         


Arg Cys His Gly Ser Gln Ala Ser Tyr Leu Phe Gln Gln Asp Lys Phe 
        355                 360                 365             


Tyr Asp Val Ala Leu Asp Thr Gly Asp Lys Val Val Gln Cys Gly Arg 
    370                 375                 380                 


Arg Val Asp Cys Leu Lys Leu Trp Leu Met Trp Lys Ala Gln Gly Asp 
385                 390                 395                 400 


Gln Gly Leu Glu Arg Arg Ile Asp Gln Ala Phe Val Leu Ala Arg Tyr 
                405                 410                 415     


Leu Val Glu Glu Met Lys Lys Arg Glu Gly Phe Glu Leu Val Met Glu 
            420                 425                 430         


Pro Glu Phe Val Asn Val Cys Phe Trp Phe Val Pro Pro Ser Leu Arg 
        435                 440                 445             


Gly Lys Gln Glu Ser Pro Asp Tyr His Glu Arg Leu Ser Lys Val Ala 
    450                 455                 460                 


Pro Val Leu Lys Glu Arg Met Val Lys Glu Gly Ser Met Met Ile Gly 
465                 470                 475                 480 


Tyr Gln Pro His Gly Thr Arg Gly Asn Phe Phe Arg Val Val Val Ala 
                485                 490                 495     


Asn Ser Ala Leu Thr Cys Ala Asp Met Asp Phe Leu Leu Asn Glu Leu 
            500                 505                 510         


Glu Arg Leu Gly Gln Asp Leu 
        515                 


<210>  3573
<211>  150
<212>  PRT
<213>  Homo Sapiens

<400>  3573

Met Gly Trp Gly Arg Leu Gln Arg Ile Ser Leu Pro Ser Gln Cys Leu 
1               5                   10                  15      


Ser Leu Leu Ser Thr Trp Leu Gly Ser Leu Leu Leu Leu Val Cys Leu 
            20                  25                  30          


Leu Ala Ser Arg Ser Ile Thr Glu Glu Val Ser Glu Tyr Cys Ser His 
        35                  40                  45              


Met Ile Gly Ser Gly His Leu Gln Ser Leu Gln Arg Leu Ile Asp Ser 
    50                  55                  60                  


Gln Met Glu Thr Ser Cys Gln Ile Thr Phe Glu Phe Val Asp Gln Glu 
65                  70                  75                  80  


Gln Leu Lys Asp Pro Val Cys Tyr Leu Lys Lys Ala Phe Leu Leu Val 
                85                  90                  95      


Gln Asp Ile Met Glu Asp Thr Met Arg Phe Arg Asp Asn Thr Pro Asn 
            100                 105                 110         


Ala Ile Ala Ile Val Gln Leu Gln Glu Leu Ser Leu Arg Leu Lys Ser 
        115                 120                 125             


Cys Phe Thr Lys Asp Tyr Glu Glu His Asp Lys Ala Cys Val Arg Thr 
    130                 135                 140                 


Phe Tyr Glu Thr Pro Leu 
145                 150 


<210>  3574
<211>  113
<212>  PRT
<213>  Homo Sapiens

<400>  3574

Met Ile Gly Ser Gly His Leu Gln Ser Leu Gln Arg Leu Ile Asp Ser 
1               5                   10                  15      


Gln Met Glu Thr Ser Cys Gln Ile Thr Phe Glu Phe Val Asp Gln Glu 
            20                  25                  30          


Gln Leu Lys Asp Pro Val Cys Tyr Leu Lys Lys Ala Phe Leu Leu Val 
        35                  40                  45              


Gln Asp Ile Met Glu Asp Thr Met Arg Phe Arg Asp Asn Thr Pro Asn 
    50                  55                  60                  


Ala Ile Ala Ile Val Gln Leu Gln Glu Leu Ser Leu Arg Leu Lys Ser 
65                  70                  75                  80  


Cys Phe Thr Lys Asp Tyr Glu Glu His Asp Lys Ala Cys Val Arg Thr 
                85                  90                  95      


Phe Tyr Glu Thr Pro Leu Gln Leu Leu Glu Lys Val Lys Asn Val Phe 
            100                 105                 110         


Asn 
    


<210>  3575
<211>  285
<212>  PRT
<213>  Homo Sapiens

<400>  3575

Met Thr Ala Pro Gly Ala Ala Gly Arg Cys Pro Pro Thr Ile Asp Ser 
1               5                   10                  15      


Gln Met Glu Thr Ser Cys Gln Ile Thr Phe Glu Phe Val Asp Gln Glu 
            20                  25                  30          


Gln Leu Lys Asp Pro Val Cys Tyr Leu Lys Lys Ala Phe Leu Leu Val 
        35                  40                  45              


Gln Asp Ile Met Glu Asp Thr Met Arg Phe Arg Asp Asn Thr Pro Asn 
    50                  55                  60                  


Ala Ile Ala Ile Val Gln Leu Gln Glu Leu Ser Leu Arg Leu Lys Ser 
65                  70                  75                  80  


Cys Phe Thr Lys Asp Tyr Glu Glu His Asp Lys Ala Cys Val Arg Thr 
                85                  90                  95      


Phe Tyr Glu Thr Pro Leu Gln Leu Leu Glu Lys Val Lys Asn Val Phe 
            100                 105                 110         


Asn Glu Thr Lys Asn Leu Leu Asp Lys Asp Trp Asn Ile Phe Ser Lys 
        115                 120                 125             


Asn Cys Asn Asn Ser Phe Ala Glu Cys Ser Ser Gln Asp Val Val Thr 
    130                 135                 140                 


Lys Pro Asp Cys Asn Cys Leu Tyr Pro Lys Ala Ile Pro Ser Ser Asp 
145                 150                 155                 160 


Pro Ala Ser Val Ser Pro His Gln Pro Leu Ala Pro Ser Met Ala Pro 
                165                 170                 175     


Val Ala Gly Leu Thr Trp Glu Asp Ser Glu Gly Thr Glu Gly Ser Ser 
            180                 185                 190         


Leu Leu Pro Gly Glu Gln Pro Leu His Thr Val Asp Pro Gly Ser Ala 
        195                 200                 205             


Lys Gln Arg Pro Pro Arg Ser Thr Cys Gln Ser Phe Glu Pro Pro Glu 
    210                 215                 220                 


Thr Pro Val Val Lys Asp Ser Thr Ile Gly Gly Ser Pro Gln Pro Arg 
225                 230                 235                 240 


Pro Ser Val Gly Ala Phe Asn Pro Gly Met Glu Asp Ile Leu Asp Ser 
                245                 250                 255     


Ala Met Gly Thr Asn Trp Val Pro Glu Glu Ala Ser Gly Glu Ala Ser 
            260                 265                 270         


Glu Ile Pro Val Pro Gln Gly Thr Glu Leu Ser Pro Ser 
        275                 280                 285 


<210>  3576
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  3576

Met Thr Ala Pro Gly Ala Ala Gly Arg Cys Pro Pro Thr Thr Trp Leu 
1               5                   10                  15      


Gly Ser Leu Leu Leu Leu Val Cys Leu Leu Ala Ser Arg Ser Ile Thr 
            20                  25                  30          


Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
        35                  40                  45              


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 
    50                  55                  60                  


Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
65                  70                  75                  80  


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr 
                85                  90                  95      


Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln Leu 
            100                 105                 110         


Gln Glu Leu Ser Leu Arg Leu 
        115                 


<210>  3577
<211>  554
<212>  PRT
<213>  Homo Sapiens

<400>  3577

Met Thr Ala Pro Gly Ala Ala Gly Arg Cys Pro Pro Thr Thr Trp Leu 
1               5                   10                  15      


Gly Ser Leu Leu Leu Leu Val Cys Leu Leu Ala Ser Arg Ser Ile Thr 
            20                  25                  30          


Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
        35                  40                  45              


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 
    50                  55                  60                  


Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
65                  70                  75                  80  


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr 
                85                  90                  95      


Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln Leu 
            100                 105                 110         


Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr Glu 
        115                 120                 125             


Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu Gln 
    130                 135                 140                 


Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 
145                 150                 155                 160 


Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 
                165                 170                 175     


Glu Cys Ser Ser Gln Asp Val Val Thr Lys Pro Asp Cys Asn Cys Leu 
            180                 185                 190         


Tyr Pro Lys Ala Ile Pro Ser Ser Asp Pro Ala Ser Val Ser Pro His 
        195                 200                 205             


Gln Pro Leu Ala Pro Ser Met Ala Pro Val Ala Gly Leu Thr Trp Glu 
    210                 215                 220                 


Asp Ser Glu Gly Thr Glu Gly Ser Ser Leu Leu Pro Gly Glu Gln Pro 
225                 230                 235                 240 


Leu His Thr Val Asp Pro Gly Ser Ala Lys Gln Arg Pro Pro Arg Ser 
                245                 250                 255     


Thr Cys Gln Ser Phe Glu Pro Pro Glu Thr Pro Val Val Lys Asp Ser 
            260                 265                 270         


Thr Ile Gly Gly Ser Pro Gln Pro Arg Pro Ser Val Gly Ala Phe Asn 
        275                 280                 285             


Pro Gly Met Glu Asp Ile Leu Asp Ser Ala Met Gly Thr Asn Trp Val 
    290                 295                 300                 


Pro Glu Glu Ala Ser Gly Glu Ala Ser Glu Ile Pro Val Pro Gln Gly 
305                 310                 315                 320 


Thr Glu Leu Ser Pro Ser Arg Pro Gly Gly Gly Ser Met Gln Thr Glu 
                325                 330                 335     


Pro Ala Arg Pro Ser Asn Phe Leu Ser Ala Ser Ser Pro Leu Pro Ala 
            340                 345                 350         


Ser Ala Lys Gly Gln Gln Pro Ala Asp Val Thr Gly Thr Ala Leu Pro 
        355                 360                 365             


Arg Val Gly Pro Val Arg Pro Thr Gly Gln Asp Trp Asn His Thr Pro 
    370                 375                 380                 


Gln Lys Thr Asp His Pro Ser Ala Leu Leu Arg Asp Pro Pro Glu Pro 
385                 390                 395                 400 


Gly Ser Pro Arg Ile Ser Ser Leu Arg Pro Gln Gly Leu Ser Asn Pro 
                405                 410                 415     


Ser Thr Leu Ser Ala Gln Pro Gln Leu Ser Arg Ser His Ser Ser Gly 
            420                 425                 430         


Ser Val Leu Pro Leu Gly Glu Leu Glu Gly Arg Arg Ser Thr Arg Asp 
        435                 440                 445             


Arg Arg Ser Pro Ala Glu Pro Glu Gly Gly Pro Ala Ser Glu Gly Ala 
    450                 455                 460                 


Ala Arg Pro Leu Pro Arg Phe Asn Ser Val Pro Leu Thr Asp Thr Gly 
465                 470                 475                 480 


His Glu Arg Gln Ser Glu Gly Ser Phe Ser Pro Gln Leu Gln Glu Ser 
                485                 490                 495     


Val Phe His Leu Leu Val Pro Ser Val Ile Leu Val Leu Leu Ala Val 
            500                 505                 510         


Gly Gly Leu Leu Phe Tyr Arg Trp Arg Arg Arg Ser His Gln Glu Pro 
        515                 520                 525             


Gln Arg Ala Asp Ser Pro Leu Glu Gln Pro Glu Gly Ser Pro Leu Thr 
    530                 535                 540                 


Gln Asp Asp Arg Gln Val Glu Leu Pro Val 
545                 550                 


<210>  3578
<211>  554
<212>  PRT
<213>  Homo Sapiens

<400>  3578

Met Thr Ala Pro Gly Ala Ala Gly Arg Cys Pro Pro Thr Thr Trp Leu 
1               5                   10                  15      


Gly Ser Leu Leu Leu Leu Val Cys Leu Leu Ala Ser Arg Ser Ile Thr 
            20                  25                  30          


Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
        35                  40                  45              


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 
    50                  55                  60                  


Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
65                  70                  75                  80  


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr 
                85                  90                  95      


Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln Leu 
            100                 105                 110         


Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr Glu 
        115                 120                 125             


Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu Gln 
    130                 135                 140                 


Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 
145                 150                 155                 160 


Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 
                165                 170                 175     


Glu Cys Ser Ser Gln Asp Val Val Thr Lys Pro Asp Cys Asn Cys Leu 
            180                 185                 190         


Tyr Pro Lys Ala Ile Pro Ser Ser Asp Pro Ala Ser Val Ser Pro His 
        195                 200                 205             


Gln Pro Leu Ala Pro Ser Met Ala Pro Val Ala Gly Leu Thr Trp Glu 
    210                 215                 220                 


Asp Ser Glu Gly Thr Glu Gly Ser Ser Leu Leu Pro Gly Glu Gln Pro 
225                 230                 235                 240 


Leu His Thr Val Asp Pro Gly Ser Ala Lys Gln Arg Pro Pro Arg Ser 
                245                 250                 255     


Thr Cys Gln Ser Phe Glu Pro Pro Glu Thr Pro Val Val Lys Asp Ser 
            260                 265                 270         


Thr Ile Gly Gly Ser Pro Gln Pro Arg Pro Ser Val Gly Ala Phe Asn 
        275                 280                 285             


Pro Gly Met Glu Asp Ile Leu Asp Ser Ala Met Gly Thr Asn Trp Val 
    290                 295                 300                 


Pro Glu Glu Ala Ser Gly Glu Ala Ser Glu Ile Pro Val Pro Gln Gly 
305                 310                 315                 320 


Thr Glu Leu Ser Pro Ser Arg Pro Gly Gly Gly Ser Met Gln Thr Glu 
                325                 330                 335     


Pro Ala Arg Pro Ser Asn Phe Leu Ser Ala Ser Ser Pro Leu Pro Ala 
            340                 345                 350         


Ser Ala Lys Gly Gln Gln Pro Ala Asp Val Thr Gly Thr Ala Leu Pro 
        355                 360                 365             


Arg Val Gly Pro Val Arg Pro Thr Gly Gln Asp Trp Asn His Thr Pro 
    370                 375                 380                 


Gln Lys Thr Asp His Pro Ser Ala Leu Leu Arg Asp Pro Pro Glu Pro 
385                 390                 395                 400 


Gly Ser Pro Arg Ile Ser Ser Leu Arg Pro Gln Gly Leu Ser Asn Pro 
                405                 410                 415     


Ser Thr Leu Ser Ala Gln Pro Gln Leu Ser Arg Ser His Ser Ser Gly 
            420                 425                 430         


Ser Val Leu Pro Leu Gly Glu Leu Glu Gly Arg Arg Ser Thr Arg Asp 
        435                 440                 445             


Arg Arg Ser Pro Ala Glu Pro Glu Gly Gly Pro Ala Ser Glu Gly Ala 
    450                 455                 460                 


Ala Arg Pro Leu Pro Arg Phe Asn Ser Val Pro Leu Thr Asp Thr Gly 
465                 470                 475                 480 


His Glu Arg Gln Ser Glu Gly Ser Phe Ser Pro Gln Leu Gln Glu Ser 
                485                 490                 495     


Val Phe His Leu Leu Val Pro Ser Val Ile Leu Val Leu Leu Ala Val 
            500                 505                 510         


Gly Gly Leu Leu Phe Tyr Arg Trp Arg Arg Arg Ser His Gln Glu Pro 
        515                 520                 525             


Gln Arg Ala Asp Ser Pro Leu Glu Gln Pro Glu Gly Ser Pro Leu Thr 
    530                 535                 540                 


Gln Asp Asp Arg Gln Val Glu Leu Pro Val 
545                 550                 


<210>  3579
<211>  438
<212>  PRT
<213>  Homo Sapiens

<400>  3579

Met Thr Ala Pro Gly Ala Ala Gly Arg Cys Pro Pro Thr Thr Trp Leu 
1               5                   10                  15      


Gly Ser Leu Leu Leu Leu Val Cys Leu Leu Ala Ser Arg Ser Ile Thr 
            20                  25                  30          


Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
        35                  40                  45              


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 
    50                  55                  60                  


Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
65                  70                  75                  80  


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr 
                85                  90                  95      


Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln Leu 
            100                 105                 110         


Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr Glu 
        115                 120                 125             


Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu Gln 
    130                 135                 140                 


Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 
145                 150                 155                 160 


Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 
                165                 170                 175     


Glu Cys Ser Ser Gln Asp Val Val Thr Lys Pro Asp Cys Asn Cys Leu 
            180                 185                 190         


Tyr Pro Lys Ala Ile Pro Ser Ser Asp Pro Ala Ser Val Ser Pro His 
        195                 200                 205             


Gln Pro Leu Ala Pro Ser Met Ala Pro Val Ala Gly Leu Thr Trp Glu 
    210                 215                 220                 


Asp Ser Glu Gly Thr Glu Gly Ser Ser Leu Leu Pro Gly Glu Gln Pro 
225                 230                 235                 240 


Leu His Thr Val Asp Pro Gly Ser Ala Lys Gln Arg Pro Pro Arg Ser 
                245                 250                 255     


Thr Cys Gln Ser Phe Glu Pro Pro Glu Thr Pro Val Val Lys Asp Ser 
            260                 265                 270         


Thr Ile Gly Gly Ser Pro Gln Pro Arg Pro Ser Val Gly Ala Phe Asn 
        275                 280                 285             


Pro Gly Met Glu Asp Ile Leu Asp Ser Ala Met Gly Thr Asn Trp Val 
    290                 295                 300                 


Pro Glu Glu Ala Ser Gly Glu Ala Ser Glu Ile Pro Val Pro Gln Gly 
305                 310                 315                 320 


Thr Glu Leu Ser Pro Ser Arg Pro Gly Gly Gly Ser Met Gln Thr Glu 
                325                 330                 335     


Pro Ala Arg Pro Ser Asn Phe Leu Ser Ala Ser Ser Pro Leu Pro Ala 
            340                 345                 350         


Ser Ala Lys Gly Gln Gln Pro Ala Asp Val Thr Gly His Glu Arg Gln 
        355                 360                 365             


Ser Glu Gly Ser Phe Ser Pro Gln Leu Gln Glu Ser Val Phe His Leu 
    370                 375                 380                 


Leu Val Pro Ser Val Ile Leu Val Leu Leu Ala Val Gly Gly Leu Leu 
385                 390                 395                 400 


Phe Tyr Arg Trp Arg Arg Arg Ser His Gln Glu Pro Gln Arg Ala Asp 
                405                 410                 415     


Ser Pro Leu Glu Gln Pro Glu Gly Ser Pro Leu Thr Gln Asp Asp Arg 
            420                 425                 430         


Gln Val Glu Leu Pro Val 
        435             


<210>  3580
<211>  256
<212>  PRT
<213>  Homo Sapiens

<400>  3580

Met Thr Ala Pro Gly Ala Ala Gly Arg Cys Pro Pro Thr Thr Trp Leu 
1               5                   10                  15      


Gly Ser Leu Leu Leu Leu Val Cys Leu Leu Ala Ser Arg Ser Ile Thr 
            20                  25                  30          


Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
        35                  40                  45              


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 
    50                  55                  60                  


Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
65                  70                  75                  80  


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr 
                85                  90                  95      


Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln Leu 
            100                 105                 110         


Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr Glu 
        115                 120                 125             


Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu Gln 
    130                 135                 140                 


Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 
145                 150                 155                 160 


Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 
                165                 170                 175     


Glu Cys Ser Ser Gln Gly His Glu Arg Gln Ser Glu Gly Ser Phe Ser 
            180                 185                 190         


Pro Gln Leu Gln Glu Ser Val Phe His Leu Leu Val Pro Ser Val Ile 
        195                 200                 205             


Leu Val Leu Leu Ala Val Gly Gly Leu Leu Phe Tyr Arg Trp Arg Arg 
    210                 215                 220                 


Arg Ser His Gln Glu Pro Gln Arg Ala Asp Ser Pro Leu Glu Gln Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Leu Thr Gln Asp Asp Arg Gln Val Glu Leu Pro Val 
                245                 250                 255     


<210>  3581
<211>  64
<212>  PRT
<213>  Homo Sapiens

<400>  3581

Ala Gly Ser Pro Trp Ala Leu Gly Gln Arg Pro Phe Gly Ala Gln Gly 
1               5                   10                  15      


Leu Lys Gly Pro Val Cys Val Ala Ala Thr Ala His Ala Asp Glu Lys 
            20                  25                  30          


Glu Ala Leu Met Ser Glu Leu Lys Ile Met Ser His Leu Gly Gln His 
        35                  40                  45              


Glu Asn Ile Val Asn Leu Leu Gly Ala Cys Thr His Gly Gly Ile Ser 
    50                  55                  60                  


<210>  3582
<211>  972
<212>  PRT
<213>  Homo Sapiens

<400>  3582

Met Gly Pro Gly Val Leu Leu Leu Leu Leu Val Ala Thr Ala Trp His 
1               5                   10                  15      


Gly Gln Gly Ile Pro Val Ile Glu Pro Ser Val Pro Glu Leu Val Val 
            20                  25                  30          


Lys Pro Gly Ala Thr Val Thr Leu Arg Cys Val Gly Asn Gly Ser Val 
        35                  40                  45              


Glu Trp Asp Gly Pro Pro Ser Pro His Trp Thr Leu Tyr Ser Asp Gly 
    50                  55                  60                  


Ser Ser Ser Ile Leu Ser Thr Asn Asn Ala Thr Phe Gln Asn Thr Gly 
65                  70                  75                  80  


Thr Tyr Arg Cys Thr Glu Pro Gly Asp Pro Leu Gly Gly Ser Ala Ala 
                85                  90                  95      


Ile His Leu Tyr Val Lys Asp Pro Ala Arg Pro Trp Asn Val Leu Ala 
            100                 105                 110         


Gln Glu Val Val Val Phe Glu Asp Gln Asp Ala Leu Leu Pro Cys Leu 
        115                 120                 125             


Leu Thr Asp Pro Val Leu Glu Ala Gly Val Ser Leu Val Arg Val Arg 
    130                 135                 140                 


Gly Arg Pro Leu Met Arg His Thr Asn Tyr Ser Phe Ser Pro Trp His 
145                 150                 155                 160 


Gly Phe Thr Ile His Arg Ala Lys Phe Ile Gln Ser Gln Asp Tyr Gln 
                165                 170                 175     


Cys Ser Ala Leu Met Gly Gly Arg Lys Val Met Ser Ile Ser Ile Arg 
            180                 185                 190         


Leu Lys Val Gln Lys Val Ile Pro Gly Pro Pro Ala Leu Thr Leu Val 
        195                 200                 205             


Pro Ala Glu Leu Val Arg Ile Arg Gly Glu Ala Ala Gln Ile Val Cys 
    210                 215                 220                 


Ser Ala Ser Ser Val Asp Val Asn Phe Asp Val Phe Leu Gln His Asn 
225                 230                 235                 240 


Asn Thr Lys Leu Ala Ile Pro Gln Gln Ser Asp Phe His Asn Asn Arg 
                245                 250                 255     


Tyr Gln Lys Val Leu Thr Leu Asn Leu Asp Gln Val Asp Phe Gln His 
            260                 265                 270         


Ala Gly Asn Tyr Ser Cys Val Ala Ser Asn Val Gln Gly Lys His Ser 
        275                 280                 285             


Thr Ser Met Phe Phe Arg Val Val Glu Ser Ala Tyr Leu Asn Leu Ser 
    290                 295                 300                 


Ser Glu Gln Asn Leu Ile Gln Glu Val Thr Val Gly Glu Gly Leu Asn 
305                 310                 315                 320 


Leu Lys Val Met Val Glu Ala Tyr Pro Gly Leu Gln Gly Phe Asn Trp 
                325                 330                 335     


Thr Tyr Leu Gly Pro Phe Ser Asp His Gln Pro Glu Pro Lys Leu Ala 
            340                 345                 350         


Asn Ala Thr Thr Lys Asp Thr Tyr Arg His Thr Phe Thr Leu Ser Leu 
        355                 360                 365             


Pro Arg Leu Lys Pro Ser Glu Ala Gly Arg Tyr Ser Phe Leu Ala Arg 
    370                 375                 380                 


Asn Pro Gly Gly Trp Arg Ala Leu Thr Phe Glu Leu Thr Leu Arg Tyr 
385                 390                 395                 400 


Pro Pro Glu Val Ser Val Ile Trp Thr Phe Ile Asn Gly Ser Gly Thr 
                405                 410                 415     


Leu Leu Cys Ala Ala Ser Gly Tyr Pro Gln Pro Asn Val Thr Trp Leu 
            420                 425                 430         


Gln Cys Ser Gly His Thr Asp Arg Cys Asp Glu Ala Gln Val Leu Gln 
        435                 440                 445             


Val Trp Asp Asp Pro Tyr Pro Glu Val Leu Ser Gln Glu Pro Phe His 
    450                 455                 460                 


Lys Val Thr Val Gln Ser Leu Leu Thr Val Glu Thr Leu Glu His Asn 
465                 470                 475                 480 


Gln Thr Tyr Glu Cys Arg Ala His Asn Ser Val Gly Ser Gly Ser Trp 
                485                 490                 495     


Ala Phe Ile Pro Ile Ser Ala Gly Ala His Thr His Pro Pro Asp Glu 
            500                 505                 510         


Phe Leu Phe Thr Pro Val Val Val Ala Cys Met Ser Ile Met Ala Leu 
        515                 520                 525             


Leu Leu Leu Leu Leu Leu Leu Leu Leu Tyr Lys Tyr Lys Gln Lys Pro 
    530                 535                 540                 


Lys Tyr Gln Val Arg Trp Lys Ile Ile Glu Ser Tyr Glu Gly Asn Ser 
545                 550                 555                 560 


Tyr Thr Phe Ile Asp Pro Thr Gln Leu Pro Tyr Asn Glu Lys Trp Glu 
                565                 570                 575     


Phe Pro Arg Asn Asn Leu Gln Phe Gly Lys Thr Leu Gly Ala Gly Ala 
            580                 585                 590         


Phe Gly Lys Val Val Glu Ala Thr Ala Phe Gly Leu Gly Lys Glu Asp 
        595                 600                 605             


Ala Val Leu Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala His Ala 
    610                 615                 620                 


Asp Glu Lys Glu Ala Leu Met Ser Glu Leu Lys Ile Met Ser His Leu 
625                 630                 635                 640 


Gly Gln His Glu Asn Ile Val Asn Leu Leu Gly Ala Cys Thr His Gly 
                645                 650                 655     


Gly Pro Val Leu Val Ile Thr Glu Tyr Cys Cys Tyr Gly Asp Leu Leu 
            660                 665                 670         


Asn Phe Leu Arg Arg Lys Ala Glu Ala Met Leu Gly Pro Ser Leu Ser 
        675                 680                 685             


Pro Gly Gln Asp Pro Glu Gly Gly Val Asp Tyr Lys Asn Ile His Leu 
    690                 695                 700                 


Glu Lys Lys Tyr Val Arg Arg Asp Ser Gly Phe Ser Ser Gln Gly Val 
705                 710                 715                 720 


Asp Thr Tyr Val Glu Met Arg Pro Val Ser Thr Ser Ser Asn Asp Ser 
                725                 730                 735     


Phe Ser Glu Gln Asp Leu Asp Lys Glu Asp Gly Arg Pro Leu Glu Leu 
            740                 745                 750         


Arg Asp Leu Leu His Phe Ser Ser Gln Val Ala Gln Gly Met Ala Phe 
        755                 760                 765             


Leu Ala Ser Lys Asn Cys Ile His Arg Asp Val Ala Ala Arg Asn Val 
    770                 775                 780                 


Leu Leu Thr Asn Gly His Val Ala Lys Ile Gly Asp Phe Gly Leu Ala 
785                 790                 795                 800 


Arg Asp Ile Met Asn Asp Ser Asn Tyr Ile Val Lys Gly Asn Ala Arg 
                805                 810                 815     


Leu Pro Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asp Cys Val Tyr 
            820                 825                 830         


Thr Val Gln Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu Ile 
        835                 840                 845             


Phe Ser Leu Gly Leu Asn Pro Tyr Pro Gly Ile Leu Val Asn Ser Lys 
    850                 855                 860                 


Phe Tyr Lys Leu Val Lys Asp Gly Tyr Gln Met Ala Gln Pro Ala Phe 
865                 870                 875                 880 


Ala Pro Lys Asn Ile Tyr Ser Ile Met Gln Ala Cys Trp Ala Leu Glu 
                885                 890                 895     


Pro Thr His Arg Pro Thr Phe Gln Gln Ile Cys Ser Phe Leu Gln Glu 
            900                 905                 910         


Gln Ala Gln Glu Asp Arg Arg Glu Arg Asp Tyr Thr Asn Leu Pro Ser 
        915                 920                 925             


Ser Ser Arg Ser Gly Gly Ser Gly Ser Ser Ser Ser Glu Leu Glu Glu 
    930                 935                 940                 


Glu Ser Ser Ser Glu His Leu Thr Cys Cys Glu Gln Gly Asp Ile Ala 
945                 950                 955                 960 


Gln Pro Leu Leu Gln Pro Asn Asn Tyr Gln Phe Cys 
                965                 970         


<210>  3583
<211>  671
<212>  PRT
<213>  Homo Sapiens

<400>  3583

Met Gly Pro Gly Val Leu Leu Leu Leu Leu Val Ala Thr Ala Trp His 
1               5                   10                  15      


Gly Gln Gly Ile Pro Val Ile Glu Pro Ser Val Pro Glu Leu Val Val 
            20                  25                  30          


Lys Pro Gly Ala Thr Val Thr Leu Arg Cys Val Gly Asn Gly Ser Val 
        35                  40                  45              


Glu Trp Asp Gly Pro Pro Ser Pro His Trp Thr Leu Tyr Ser Asp Gly 
    50                  55                  60                  


Ser Ser Ser Ile Leu Ser Thr Asn Asn Ala Thr Phe Gln Asn Thr Gly 
65                  70                  75                  80  


Thr Tyr Arg Cys Thr Glu Pro Gly Asp Pro Leu Gly Gly Ser Ala Ala 
                85                  90                  95      


Ile His Leu Tyr Val Lys Asp Pro Ala Arg Pro Trp Asn Val Leu Ala 
            100                 105                 110         


Gln Glu Val Val Val Phe Glu Asp Gln Asp Ala Leu Leu Pro Cys Leu 
        115                 120                 125             


Leu Thr Asp Pro Val Leu Glu Ala Gly Val Ser Leu Val Arg Val Arg 
    130                 135                 140                 


Gly Arg Pro Leu Met Arg His Thr Asn Tyr Ser Phe Ser Pro Trp His 
145                 150                 155                 160 


Gly Phe Thr Ile His Arg Ala Lys Phe Ile Gln Ser Gln Asp Tyr Gln 
                165                 170                 175     


Cys Ser Ala Leu Met Gly Gly Arg Lys Val Met Ser Ile Ser Ile Arg 
            180                 185                 190         


Leu Lys Val Gln Lys Val Ile Pro Gly Pro Pro Ala Leu Thr Leu Val 
        195                 200                 205             


Pro Ala Glu Leu Val Arg Ile Arg Gly Glu Ala Ala Gln Ile Val Cys 
    210                 215                 220                 


Ser Ala Ser Ser Val Asp Val Asn Phe Asp Val Phe Leu Gln His Asn 
225                 230                 235                 240 


Asn Thr Lys Leu Ala Ile Pro Gln Gln Ser Asp Phe His Asn Asn Arg 
                245                 250                 255     


Tyr Gln Lys Val Leu Thr Leu Asn Leu Asp Gln Val Asp Phe Gln His 
            260                 265                 270         


Ala Gly Asn Tyr Ser Cys Val Ala Ser Asn Val Gln Gly Lys His Ser 
        275                 280                 285             


Thr Ser Met Phe Phe Arg Val Val Glu Ser Ala Tyr Leu Asn Leu Ser 
    290                 295                 300                 


Ser Glu Gln Asn Leu Ile Gln Glu Val Thr Val Gly Glu Gly Leu Asn 
305                 310                 315                 320 


Leu Lys Val Met Val Glu Ala Tyr Pro Gly Leu Gln Gly Phe Asn Trp 
                325                 330                 335     


Thr Tyr Leu Gly Pro Phe Ser Asp His Gln Pro Glu Pro Lys Leu Ala 
            340                 345                 350         


Asn Ala Thr Thr Lys Asp Thr Tyr Arg His Thr Phe Thr Leu Ser Leu 
        355                 360                 365             


Pro Arg Leu Lys Pro Ser Glu Ala Gly Arg Tyr Ser Phe Leu Ala Arg 
    370                 375                 380                 


Asn Pro Gly Gly Trp Arg Ala Leu Thr Phe Glu Leu Thr Leu Arg Tyr 
385                 390                 395                 400 


Pro Pro Glu Val Ser Val Ile Trp Thr Phe Ile Asn Gly Ser Gly Thr 
                405                 410                 415     


Leu Leu Cys Ala Ala Ser Gly Tyr Pro Gln Pro Asn Val Thr Trp Leu 
            420                 425                 430         


Gln Cys Ser Gly His Thr Asp Arg Cys Asp Glu Ala Gln Val Leu Gln 
        435                 440                 445             


Val Trp Asp Asp Pro Tyr Pro Glu Val Leu Ser Gln Glu Pro Phe His 
    450                 455                 460                 


Lys Val Thr Val Gln Ser Leu Leu Thr Val Glu Thr Leu Glu His Asn 
465                 470                 475                 480 


Gln Thr Tyr Glu Cys Arg Ala His Asn Ser Val Gly Ser Gly Ser Trp 
                485                 490                 495     


Ala Phe Ile Pro Ile Ser Ala Gly Ala His Thr His Pro Pro Asp Glu 
            500                 505                 510         


Phe Leu Phe Thr Pro Val Val Val Ala Cys Met Ser Ile Met Ala Leu 
        515                 520                 525             


Leu Leu Leu Leu Leu Leu Leu Leu Leu Tyr Lys Tyr Lys Gln Lys Pro 
    530                 535                 540                 


Lys Tyr Gln Val Arg Trp Lys Ile Ile Glu Ser Tyr Glu Gly Asn Ser 
545                 550                 555                 560 


Tyr Thr Phe Ile Asp Pro Thr Gln Leu Pro Tyr Asn Glu Lys Trp Glu 
                565                 570                 575     


Phe Pro Arg Asn Asn Leu Gln Phe Gly Lys Thr Leu Gly Ala Gly Ala 
            580                 585                 590         


Phe Gly Lys Val Val Glu Ala Thr Ala Phe Gly Leu Gly Lys Glu Asp 
        595                 600                 605             


Ala Val Leu Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala His Ala 
    610                 615                 620                 


Asp Glu Lys Glu Ala Leu Met Ser Glu Leu Lys Ile Met Ser His Leu 
625                 630                 635                 640 


Gly Gln His Glu Asn Ile Val Asn Leu Leu Gly Ala Cys Thr His Gly 
                645                 650                 655     


Gly Thr Val Ala Ser Pro Ala Arg Val Trp Thr Pro Met Trp Arg 
            660                 665                 670     


<210>  3584
<211>  306
<212>  PRT
<213>  Homo Sapiens

<400>  3584

Met Gly Pro Gly Val Leu Leu Leu Leu Leu Val Ala Thr Ala Trp His 
1               5                   10                  15      


Gly Gln Gly Ile Pro Val Ile Glu Pro Ser Val Pro Glu Leu Val Val 
            20                  25                  30          


Lys Pro Gly Ala Thr Val Thr Leu Arg Cys Val Gly Asn Gly Ser Val 
        35                  40                  45              


Glu Trp Asp Gly Pro Pro Ser Pro His Trp Thr Leu Tyr Ser Asp Gly 
    50                  55                  60                  


Ser Ser Ser Ile Leu Ser Thr Asn Asn Ala Thr Phe Gln Asn Thr Gly 
65                  70                  75                  80  


Thr Tyr Arg Cys Thr Glu Pro Gly Asp Pro Leu Gly Gly Ser Ala Ala 
                85                  90                  95      


Ile His Leu Tyr Val Lys Asp Pro Ala Arg Pro Trp Asn Val Leu Ala 
            100                 105                 110         


Gln Glu Val Val Val Phe Glu Asp Gln Asp Ala Leu Leu Pro Cys Leu 
        115                 120                 125             


Leu Thr Asp Pro Val Leu Glu Ala Gly Val Ser Leu Val Arg Val Arg 
    130                 135                 140                 


Gly Arg Pro Leu Met Arg His Thr Asn Tyr Ser Phe Ser Pro Trp His 
145                 150                 155                 160 


Gly Phe Thr Ile His Arg Ala Lys Phe Ile Gln Ser Gln Asp Tyr Gln 
                165                 170                 175     


Cys Ser Ala Leu Met Gly Gly Arg Lys Val Met Ser Ile Ser Ile Arg 
            180                 185                 190         


Leu Lys Val Gln Lys Val Ile Pro Gly Pro Pro Ala Leu Thr Leu Val 
        195                 200                 205             


Pro Ala Glu Leu Val Arg Ile Arg Gly Glu Ala Ala Gln Ile Val Cys 
    210                 215                 220                 


Ser Ala Ser Ser Val Asp Val Asn Phe Asp Val Phe Leu Gln His Asn 
225                 230                 235                 240 


Asn Thr Lys Leu Ala Ile Pro Gln Gln Ser Asp Phe His Asn Asn Arg 
                245                 250                 255     


Tyr Gln Lys Val Leu Thr Leu Asn Leu Asp Gln Val Asp Phe Gln His 
            260                 265                 270         


Ala Gly Asn Tyr Ser Cys Val Ala Ser Asn Val Gln Gly Lys His Ser 
        275                 280                 285             


Thr Ser Met Phe Phe Arg Val Val Gly Thr Pro Ser Pro Ser Leu Cys 
    290                 295                 300                 


Pro Ala 
305     


<210>  3585
<211>  49
<212>  PRT
<213>  Homo Sapiens

<400>  3585

Met Arg His Thr Asn Tyr Ser Phe Ser Pro Trp His Gly Phe Thr Ile 
1               5                   10                  15      


His Arg Ala Lys Phe Ile Gln Ser Gln Asp Tyr Gln Cys Ser Ala Leu 
            20                  25                  30          


Met Gly Gly Arg Lys Val Met Ser Ile Ser Ile Arg Leu Lys Val Gln 
        35                  40                  45              


Lys 
    


<210>  3586
<211>  144
<212>  PRT
<213>  Homo Sapiens

<400>  3586

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 


<210>  3587
<211>  238
<212>  PRT
<213>  Homo Sapiens

<400>  3587

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Thr Val Ala Pro 
            20                  25                  30          


Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Thr Met Asn Leu Ser 
        35                  40                  45              


Trp Asp Cys Gln Glu Asn Thr Thr Phe Ser Lys Cys Phe Leu Thr Asp 
    50                  55                  60                  


Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser 
65                  70                  75                  80  


Cys Thr Phe Arg Glu Ile Cys Leu His Glu Gly Val Thr Phe Glu Val 
                85                  90                  95      


His Val Asn Thr Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro 
            100                 105                 110         


Asn Ser Gly Arg Glu Gly Thr Ala Ala Gln Asn Phe Ser Cys Phe Ile 
        115                 120                 125             


Tyr Asn Ala Asp Leu Met Asn Cys Thr Trp Ala Arg Gly Pro Thr Ala 
    130                 135                 140                 


Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg 
145                 150                 155                 160 


Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Thr His Val 
                165                 170                 175     


Gly Cys His Leu Asp Asn Leu Ser Gly Leu Thr Ser Arg Asn Tyr Phe 
            180                 185                 190         


Leu Val Asn Gly Thr Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser 
        195                 200                 205             


Leu Leu Asp Thr Lys Lys Ile Glu Arg Phe Asn Pro Pro Ser Asn Val 
    210                 215                 220                 


Thr Val Arg Cys Asn Thr Thr His Cys Leu Val Arg Trp Lys 
225                 230                 235             


<210>  3588
<211>  377
<212>  PRT
<213>  Homo Sapiens

<400>  3588

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Thr Val Ala Pro 
            20                  25                  30          


Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Thr Met Asn Leu Ser 
        35                  40                  45              


Trp Asp Cys Gln Glu Asn Thr Thr Phe Ser Lys Cys Phe Leu Thr Asp 
    50                  55                  60                  


Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser 
65                  70                  75                  80  


Cys Thr Phe Arg Glu Ile Cys Leu His Glu Gly Val Thr Phe Glu Val 
                85                  90                  95      


His Val Asn Thr Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro 
            100                 105                 110         


Asn Ser Gly Arg Glu Gly Thr Ala Ala Gln Asn Phe Ser Cys Phe Ile 
        115                 120                 125             


Tyr Asn Ala Asp Leu Met Asn Cys Thr Trp Ala Arg Gly Pro Thr Ala 
    130                 135                 140                 


Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg 
145                 150                 155                 160 


Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Thr His Val 
                165                 170                 175     


Gly Cys His Leu Asp Asn Leu Ser Gly Leu Thr Ser Arg Asn Tyr Phe 
            180                 185                 190         


Leu Val Asn Gly Thr Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser 
        195                 200                 205             


Leu Leu Asp Thr Lys Lys Ile Glu Arg Phe Asn Pro Pro Ser Asn Val 
    210                 215                 220                 


Thr Val Arg Cys Asn Thr Thr His Cys Leu Val Arg Trp Lys Gln Pro 
225                 230                 235                 240 


Arg Thr Tyr Gln Lys Leu Ser Tyr Leu Asp Phe Gln Tyr Gln Leu Asp 
                245                 250                 255     


Val His Arg Lys Asn Thr Gln Pro Gly Thr Glu Asn Leu Leu Ile Asn 
            260                 265                 270         


Val Ser Gly Asp Leu Glu Asn Arg Tyr Asn Phe Pro Ser Ser Glu Pro 
        275                 280                 285             


Arg Ala Lys His Ser Val Lys Ile Arg Ala Ala Asp Val Arg Ile Leu 
    290                 295                 300                 


Asn Trp Ser Ser Trp Ser Glu Ala Ile Glu Phe Asp His Leu Gly Gly 
305                 310                 315                 320 


Ile His Pro Arg Gly Arg Glu Arg Leu Pro Arg Arg Gly Leu Asp Arg 
                325                 330                 335     


Glu Gly Asn Tyr Leu Arg Pro Arg Gly Cys Arg Asn Gly Met Asp Ile 
            340                 345                 350         


Ser Ala Ser Ala Thr Arg Gly Asn Cys Phe Leu Asp Asp Ala Val Asn 
        355                 360                 365             


Leu Tyr Ile Ile Phe Tyr Val Phe Ile 
    370                 375         


<210>  3589
<211>  410
<212>  PRT
<213>  Homo Sapiens

<400>  3589

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Thr Val Ala Pro 
            20                  25                  30          


Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Thr Met Asn Leu Ser 
        35                  40                  45              


Trp Asp Cys Gln Glu Asn Thr Thr Phe Ser Lys Cys Phe Leu Thr Asp 
    50                  55                  60                  


Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser 
65                  70                  75                  80  


Cys Thr Phe Arg Glu Ile Cys Leu His Glu Gly Val Thr Phe Glu Val 
                85                  90                  95      


His Val Asn Thr Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro 
            100                 105                 110         


Asn Ser Gly Arg Glu Gly Thr Ala Ala Gln Asn Phe Ser Cys Phe Ile 
        115                 120                 125             


Tyr Asn Ala Asp Leu Met Asn Cys Thr Trp Ala Arg Gly Pro Thr Ala 
    130                 135                 140                 


Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg 
145                 150                 155                 160 


Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Thr His Val 
                165                 170                 175     


Gly Cys His Leu Asp Asn Leu Ser Gly Leu Thr Ser Arg Asn Tyr Phe 
            180                 185                 190         


Leu Val Asn Gly Thr Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser 
        195                 200                 205             


Leu Leu Asp Thr Lys Lys Ile Glu Arg Phe Asn Pro Pro Ser Asn Val 
    210                 215                 220                 


Thr Val Arg Cys Asn Thr Thr His Cys Leu Val Arg Trp Lys Gln Pro 
225                 230                 235                 240 


Arg Thr Tyr Gln Lys Leu Ser Tyr Leu Asp Phe Gln Tyr Gln Leu Asp 
                245                 250                 255     


Val His Arg Lys Asn Thr Gln Pro Gly Thr Glu Asn Leu Leu Ile Asn 
            260                 265                 270         


Val Ser Gly Asp Leu Glu Asn Arg Tyr Asn Phe Pro Ser Ser Glu Pro 
        275                 280                 285             


Arg Ala Lys His Ser Val Lys Ile Arg Ala Ala Asp Val Arg Ile Leu 
    290                 295                 300                 


Asn Trp Ser Ser Trp Ser Glu Ala Ile Glu Phe Gly Ser Asp Asp Gly 
305                 310                 315                 320 


Asn Leu Gly Ser Val Tyr Ile Tyr Val Leu Leu Ile Val Gly Thr Leu 
                325                 330                 335     


Val Cys Gly Ile Val Leu Gly Phe Leu Phe Lys Arg Phe Leu Arg Ile 
            340                 345                 350         


Gln Arg Leu Phe Pro Pro Val Pro Gln Ile Lys Asp Lys Leu Asn Asp 
        355                 360                 365             


Asn His Glu Val Glu Asp Glu Met Gly Pro Gln Arg His His Arg Cys 
    370                 375                 380                 


Gly Trp Asn Leu Tyr Pro Thr Pro Gly Pro Ser Pro Gly Ser Gly Ser 
385                 390                 395                 400 


Ser Pro Arg Leu Gly Ser Glu Ser Ser Leu 
                405                 410 


<210>  3590
<211>  333
<212>  PRT
<213>  Homo Sapiens

<400>  3590

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Thr Val Ala Pro 
            20                  25                  30          


Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Thr Met Asn Leu Ser 
        35                  40                  45              


Trp Asp Cys Gln Glu Asn Thr Thr Phe Ser Lys Cys Phe Leu Thr Asp 
    50                  55                  60                  


Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser 
65                  70                  75                  80  


Cys Thr Phe Arg Glu Ile Cys Leu His Glu Gly Val Thr Phe Glu Val 
                85                  90                  95      


His Val Asn Thr Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro 
            100                 105                 110         


Asn Ser Gly Arg Glu Gly Thr Ala Ala Gln Asn Phe Ser Cys Phe Ile 
        115                 120                 125             


Tyr Asn Ala Asp Leu Met Asn Cys Thr Trp Ala Arg Gly Pro Thr Ala 
    130                 135                 140                 


Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg 
145                 150                 155                 160 


Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Thr His Val 
                165                 170                 175     


Gly Cys His Leu Asp Asn Leu Ser Gly Leu Thr Ser Arg Asn Tyr Phe 
            180                 185                 190         


Leu Val Asn Gly Thr Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser 
        195                 200                 205             


Leu Leu Asp Thr Lys Lys Ile Glu Arg Phe Asn Pro Pro Ser Asn Val 
    210                 215                 220                 


Thr Val Arg Cys Asn Thr Thr His Cys Leu Val Arg Trp Lys Gln Pro 
225                 230                 235                 240 


Arg Thr Tyr Gln Lys Leu Ser Tyr Leu Asp Phe Gln Tyr Gln Leu Asp 
                245                 250                 255     


Val His Arg Lys Asn Thr Gln Pro Gly Thr Glu Asn Leu Leu Ile Asn 
            260                 265                 270         


Val Ser Gly Asp Leu Glu Asn Arg Tyr Asn Phe Pro Ser Ser Glu Pro 
        275                 280                 285             


Arg Ala Lys His Ser Val Lys Ile Arg Ala Ala Asp Val Arg Ile Leu 
    290                 295                 300                 


Asn Trp Ser Ser Trp Ser Glu Ala Ile Glu Phe Gly Ser Leu Gly Tyr 
305                 310                 315                 320 


Ser Gly Cys Ser Arg Gln Phe His Arg Ser Lys Thr Asn 
                325                 330             


<210>  3591
<211>  400
<212>  PRT
<213>  Homo Sapiens

<400>  3591

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Thr Val Ala Pro 
            20                  25                  30          


Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Thr Met Asn Leu Ser 
        35                  40                  45              


Trp Asp Cys Gln Glu Asn Thr Thr Phe Ser Lys Cys Phe Leu Thr Asp 
    50                  55                  60                  


Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser 
65                  70                  75                  80  


Cys Thr Phe Arg Glu Ile Cys Leu His Glu Gly Val Thr Phe Glu Val 
                85                  90                  95      


His Val Asn Thr Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro 
            100                 105                 110         


Asn Ser Gly Arg Glu Gly Thr Ala Ala Gln Asn Phe Ser Cys Phe Ile 
        115                 120                 125             


Tyr Asn Ala Asp Leu Met Asn Cys Thr Trp Ala Arg Gly Pro Thr Ala 
    130                 135                 140                 


Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg 
145                 150                 155                 160 


Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Thr His Val 
                165                 170                 175     


Gly Cys His Leu Asp Asn Leu Ser Gly Leu Thr Ser Arg Asn Tyr Phe 
            180                 185                 190         


Leu Val Asn Gly Thr Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser 
        195                 200                 205             


Leu Leu Asp Thr Lys Lys Ile Glu Arg Phe Asn Pro Pro Ser Asn Val 
    210                 215                 220                 


Thr Val Arg Cys Asn Thr Thr His Cys Leu Val Arg Trp Lys Gln Pro 
225                 230                 235                 240 


Arg Thr Tyr Gln Lys Leu Ser Tyr Leu Asp Phe Gln Tyr Gln Leu Asp 
                245                 250                 255     


Val His Arg Lys Asn Thr Gln Pro Gly Thr Glu Asn Leu Leu Ile Asn 
            260                 265                 270         


Val Ser Gly Asp Leu Glu Asn Arg Tyr Asn Phe Pro Ser Ser Glu Pro 
        275                 280                 285             


Arg Ala Lys His Ser Val Lys Ile Arg Ala Ala Asp Val Arg Ile Leu 
    290                 295                 300                 


Asn Trp Ser Ser Trp Ser Glu Ala Ile Glu Phe Gly Ser Asp Asp Gly 
305                 310                 315                 320 


Asn Leu Gly Ser Val Tyr Ile Tyr Val Leu Leu Ile Val Gly Thr Leu 
                325                 330                 335     


Val Cys Gly Ile Val Leu Gly Phe Leu Phe Lys Arg Phe Leu Arg Ile 
            340                 345                 350         


Gln Arg Leu Phe Pro Pro Val Pro Gln Ile Lys Asp Lys Leu Asn Asp 
        355                 360                 365             


Asn His Glu Val Glu Asp Glu Ile Ile Trp Glu Glu Phe Thr Pro Glu 
    370                 375                 380                 


Glu Gly Lys Gly Tyr Arg Glu Glu Val Leu Thr Val Lys Glu Ile Thr 
385                 390                 395                 400 


<210>  3592
<211>  400
<212>  PRT
<213>  Homo Sapiens

<400>  3592

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Thr Val Ala Pro 
            20                  25                  30          


Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Thr Met Asn Leu Ser 
        35                  40                  45              


Trp Asp Cys Gln Glu Asn Thr Thr Phe Ser Lys Cys Phe Leu Thr Asp 
    50                  55                  60                  


Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser 
65                  70                  75                  80  


Cys Thr Phe Arg Glu Ile Cys Leu His Glu Gly Val Thr Phe Glu Val 
                85                  90                  95      


His Val Asn Thr Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro 
            100                 105                 110         


Asn Ser Gly Arg Glu Gly Thr Ala Ala Gln Asn Phe Ser Cys Phe Ile 
        115                 120                 125             


Tyr Asn Ala Asp Leu Met Asn Cys Thr Trp Ala Arg Gly Pro Thr Ala 
    130                 135                 140                 


Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg 
145                 150                 155                 160 


Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Thr His Val 
                165                 170                 175     


Gly Cys His Leu Asp Asn Leu Ser Gly Leu Thr Ser Arg Asn Tyr Phe 
            180                 185                 190         


Leu Val Asn Gly Thr Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser 
        195                 200                 205             


Leu Leu Asp Thr Lys Lys Ile Glu Arg Phe Asn Pro Pro Ser Asn Val 
    210                 215                 220                 


Thr Val Arg Cys Asn Thr Thr His Cys Leu Val Arg Trp Lys Gln Pro 
225                 230                 235                 240 


Arg Thr Tyr Gln Lys Leu Ser Tyr Leu Asp Phe Gln Tyr Gln Leu Asp 
                245                 250                 255     


Val His Arg Lys Asn Thr Gln Pro Gly Thr Glu Asn Leu Leu Ile Asn 
            260                 265                 270         


Val Ser Gly Asp Leu Glu Asn Arg Tyr Asn Phe Pro Ser Ser Glu Pro 
        275                 280                 285             


Arg Ala Lys His Ser Val Lys Ile Arg Ala Ala Asp Val Arg Ile Leu 
    290                 295                 300                 


Asn Trp Ser Ser Trp Ser Glu Ala Ile Glu Phe Gly Ser Asp Asp Gly 
305                 310                 315                 320 


Asn Leu Gly Ser Val Tyr Ile Tyr Val Leu Leu Ile Val Gly Thr Leu 
                325                 330                 335     


Val Cys Gly Ile Val Leu Gly Phe Leu Phe Lys Arg Phe Leu Arg Ile 
            340                 345                 350         


Gln Arg Leu Phe Pro Pro Val Pro Gln Ile Lys Asp Lys Leu Asn Asp 
        355                 360                 365             


Asn His Glu Val Glu Asp Glu Ile Ile Trp Glu Glu Phe Thr Pro Glu 
    370                 375                 380                 


Glu Gly Lys Gly Tyr Arg Glu Glu Val Leu Thr Val Lys Glu Ile Thr 
385                 390                 395                 400 


<210>  3593
<211>  434
<212>  PRT
<213>  Homo Sapiens

<400>  3593

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Thr Val Ala Pro 
            20                  25                  30          


Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Thr Met Asn Leu Ser 
        35                  40                  45              


Trp Asp Cys Gln Glu Asn Thr Thr Phe Ser Lys Cys Phe Leu Thr Asp 
    50                  55                  60                  


Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser 
65                  70                  75                  80  


Cys Thr Phe Arg Glu Ile Cys Leu His Glu Gly Val Thr Phe Glu Val 
                85                  90                  95      


His Val Asn Thr Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro 
            100                 105                 110         


Asn Ser Gly Arg Glu Gly Thr Ala Ala Gln Asn Phe Ser Cys Phe Ile 
        115                 120                 125             


Tyr Asn Ala Asp Leu Met Asn Cys Thr Trp Ala Arg Gly Pro Thr Ala 
    130                 135                 140                 


Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg 
145                 150                 155                 160 


Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Thr His Val 
                165                 170                 175     


Gly Cys His Leu Asp Asn Leu Ser Gly Leu Thr Ser Arg Asn Tyr Phe 
            180                 185                 190         


Leu Val Asn Gly Thr Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser 
        195                 200                 205             


Leu Leu Asp Thr Lys Lys Ile Glu Arg Phe Asn Pro Pro Ser Asn Val 
    210                 215                 220                 


Thr Val Arg Cys Asn Thr Thr His Cys Leu Val Arg Trp Lys Gln Pro 
225                 230                 235                 240 


Arg Thr Tyr Gln Lys Leu Ser Tyr Leu Asp Phe Gln Tyr Gln Leu Asp 
                245                 250                 255     


Val His Arg Lys Asn Thr Gln Pro Gly Thr Glu Asn Leu Leu Ile Asn 
            260                 265                 270         


Val Ser Gly Asp Leu Glu Asn Arg Tyr Asn Phe Pro Ser Ser Glu Pro 
        275                 280                 285             


Arg Ala Lys His Ser Val Lys Ile Arg Ala Ala Asp Val Arg Ile Leu 
    290                 295                 300                 


Asn Trp Ser Ser Trp Ser Glu Ala Ile Glu Phe Gly Ser His Ser Val 
305                 310                 315                 320 


Thr Gln Ala Gly Val Gln Trp His Asn Leu Gly Ser Leu Gln Pro Pro 
                325                 330                 335     


Ser Pro Arg Leu Lys Arg Phe Ser Cys Leu Arg Leu Pro Gly Ser Asp 
            340                 345                 350         


Asp Gly Asn Leu Gly Ser Val Tyr Ile Tyr Val Leu Leu Ile Val Gly 
        355                 360                 365             


Thr Leu Val Cys Gly Ile Val Leu Gly Phe Leu Phe Lys Arg Phe Leu 
    370                 375                 380                 


Arg Ile Gln Arg Leu Phe Pro Pro Val Pro Gln Ile Lys Asp Lys Leu 
385                 390                 395                 400 


Asn Asp Asn His Glu Val Glu Asp Glu Ile Ile Trp Glu Glu Phe Thr 
                405                 410                 415     


Pro Glu Glu Gly Lys Gly Tyr Arg Glu Glu Val Leu Thr Val Lys Glu 
            420                 425                 430         


Ile Thr 
        


<210>  3594
<211>  285
<212>  PRT
<213>  Homo Sapiens

<400>  3594

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Thr Val Ala Pro 
            20                  25                  30          


Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Thr Met Asn Leu Ser 
        35                  40                  45              


Trp Asp Cys Gln Glu Asn Thr Thr Phe Ser Lys Cys Phe Leu Thr Asp 
    50                  55                  60                  


Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser 
65                  70                  75                  80  


Cys Thr Phe Arg Glu Ile Cys Leu His Glu Gly Val Thr Phe Glu Val 
                85                  90                  95      


His Val Asn Thr Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro 
            100                 105                 110         


Asn Ser Gly Arg Glu Gly Thr Ala Ala Gln Asn Phe Ser Cys Phe Ile 
        115                 120                 125             


Tyr Asn Ala Asp Leu Met Asn Cys Thr Trp Ala Arg Gly Pro Thr Ala 
    130                 135                 140                 


Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg 
145                 150                 155                 160 


Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Thr His Val 
                165                 170                 175     


Gly Cys His Leu Asp Asn Leu Ser Gly Leu Thr Ser Arg Asn Tyr Phe 
            180                 185                 190         


Leu Val Asn Gly Thr Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser 
        195                 200                 205             


Leu Leu Asp Thr Lys Lys Ile Glu Arg Phe Asn Pro Pro Ser Asn Val 
    210                 215                 220                 


Thr Val Arg Cys Asn Thr Thr His Cys Leu Val Arg Trp Lys Gln Pro 
225                 230                 235                 240 


Arg Thr Tyr Gln Lys Leu Ser Tyr Leu Asp Phe Gln Tyr Gln Leu Asp 
                245                 250                 255     


Val His Arg Lys Asn Thr Gln Pro Gly Thr Glu Asn Leu Leu Val Leu 
            260                 265                 270         


Thr Thr Gly Thr Ser Ala Leu Cys Thr Phe Met Cys Ser 
        275                 280                 285 


<210>  3595
<211>  400
<212>  PRT
<213>  Homo Sapiens

<400>  3595

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Thr Val Ala Pro 
            20                  25                  30          


Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Thr Met Asn Leu Ser 
        35                  40                  45              


Trp Asp Cys Gln Glu Asn Thr Thr Phe Ser Lys Cys Phe Leu Thr Asp 
    50                  55                  60                  


Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser 
65                  70                  75                  80  


Cys Thr Phe Arg Glu Ile Cys Leu His Glu Gly Val Thr Phe Glu Val 
                85                  90                  95      


His Val Asn Thr Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro 
            100                 105                 110         


Asn Ser Gly Arg Glu Gly Thr Ala Ala Gln Asn Phe Ser Cys Phe Ile 
        115                 120                 125             


Tyr Asn Ala Asp Leu Met Asn Cys Thr Trp Ala Arg Gly Pro Thr Ala 
    130                 135                 140                 


Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg 
145                 150                 155                 160 


Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Thr His Val 
                165                 170                 175     


Gly Cys His Leu Asp Asn Leu Ser Gly Leu Thr Ser Arg Asn Tyr Phe 
            180                 185                 190         


Leu Val Asn Gly Thr Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser 
        195                 200                 205             


Leu Leu Asp Thr Lys Lys Ile Glu Arg Phe Asn Pro Pro Ser Asn Val 
    210                 215                 220                 


Thr Val Arg Cys Asn Thr Thr His Cys Leu Val Arg Trp Lys Gln Pro 
225                 230                 235                 240 


Arg Thr Tyr Gln Lys Leu Ser Tyr Leu Asp Phe Gln Tyr Gln Leu Asp 
                245                 250                 255     


Val His Arg Lys Asn Thr Gln Pro Gly Thr Glu Asn Leu Leu Ile Asn 
            260                 265                 270         


Val Ser Gly Asp Leu Glu Asn Arg Tyr Asn Phe Pro Ser Ser Glu Pro 
        275                 280                 285             


Arg Ala Lys His Ser Val Lys Ile Arg Ala Ala Asp Val Arg Ile Leu 
    290                 295                 300                 


Asn Trp Ser Ser Trp Ser Glu Ala Ile Glu Phe Gly Ser Asp Asp Gly 
305                 310                 315                 320 


Asn Leu Gly Ser Val Tyr Ile Tyr Val Leu Leu Ile Val Gly Thr Leu 
                325                 330                 335     


Val Cys Gly Ile Val Leu Gly Phe Leu Phe Lys Arg Phe Leu Arg Ile 
            340                 345                 350         


Gln Arg Leu Phe Pro Pro Val Pro Gln Ile Lys Asp Lys Leu Asn Asp 
        355                 360                 365             


Asn His Glu Val Glu Asp Glu Ile Ile Trp Glu Glu Phe Thr Pro Glu 
    370                 375                 380                 


Glu Gly Lys Gly Tyr Arg Glu Glu Val Leu Thr Val Lys Glu Ile Thr 
385                 390                 395                 400 


<210>  3596
<211>  233
<212>  PRT
<213>  Homo Sapiens

<400>  3596

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Thr Val Ala Pro 
            20                  25                  30          


Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Thr Met Asn Leu Ser 
        35                  40                  45              


Trp Asp Cys Gln Glu Asn Thr Thr Phe Ser Lys Cys Phe Leu Thr Asp 
    50                  55                  60                  


Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser 
65                  70                  75                  80  


Cys Thr Phe Arg Glu Ile Cys Leu His Glu Gly Val Thr Phe Glu Val 
                85                  90                  95      


His Val Asn Thr Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro 
            100                 105                 110         


Asn Ser Gly Arg Glu Gly Thr Ala Ala Gln Asn Phe Ser Cys Phe Ile 
        115                 120                 125             


Tyr Asn Ala Asp Leu Met Asn Cys Thr Trp Ala Arg Gly Pro Thr Ala 
    130                 135                 140                 


Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg 
145                 150                 155                 160 


Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Thr His Val 
                165                 170                 175     


Gly Cys His Leu Asp Asn Leu Ser Gly Leu Thr Ser Arg Asn Tyr Phe 
            180                 185                 190         


Leu Val Asn Gly Thr Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser 
        195                 200                 205             


Leu Leu Asp Thr Lys Lys Ile Gly Ser Leu Gly Tyr Ser Gly Cys Ser 
    210                 215                 220                 


Arg Gln Phe His Arg Ser Lys Thr Asn 
225                 230             


<210>  3597
<211>  90
<212>  PRT
<213>  Homo Sapiens

<400>  3597

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Thr Val Ala Pro 
            20                  25                  30          


Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Thr Met Asn Leu Ser 
        35                  40                  45              


Trp Asp Cys Gln Glu Asn Thr Thr Phe Ser Lys Cys Phe Leu Thr Asp 
    50                  55                  60                  


Lys Lys Asn Arg Val Val Glu Pro Arg Met Glu Phe Pro Ser Cys Cys 
65                  70                  75                  80  


Pro Asp Arg Thr Ile Ala His Gln Pro Ala 
                85                  90  


<210>  3598
<211>  267
<212>  PRT
<213>  Homo Sapiens

<400>  3598

Met Asn Cys Thr Trp Ala Arg Gly Pro Thr Ala Pro Arg Asp Val Gln 
1               5                   10                  15      


Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg Arg Glu Ile Arg Cys 
            20                  25                  30          


Pro Tyr Tyr Ile Gln Asp Ser Gly Thr His Val Gly Cys His Leu Asp 
        35                  40                  45              


Asn Leu Ser Gly Leu Thr Ser Arg Asn Tyr Phe Leu Val Asn Gly Thr 
    50                  55                  60                  


Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser Leu Leu Asp Thr Lys 
65                  70                  75                  80  


Lys Ile Glu Arg Phe Asn Pro Pro Ser Asn Val Thr Val Arg Cys Asn 
                85                  90                  95      


Thr Thr His Cys Leu Val Arg Trp Lys Gln Pro Arg Thr Tyr Gln Lys 
            100                 105                 110         


Leu Ser Tyr Leu Asp Phe Gln Tyr Gln Leu Asp Val His Arg Lys Asn 
        115                 120                 125             


Thr Gln Pro Gly Thr Glu Asn Leu Leu Ile Asn Val Ser Gly Asp Leu 
    130                 135                 140                 


Glu Asn Arg Tyr Asn Phe Pro Ser Ser Glu Pro Arg Ala Lys His Ser 
145                 150                 155                 160 


Val Lys Ile Arg Ala Ala Asp Val Arg Ile Leu Asn Trp Ser Ser Trp 
                165                 170                 175     


Ser Glu Ala Ile Glu Phe Gly Ser Asp Asp Gly Asn Leu Gly Ser Val 
            180                 185                 190         


Tyr Ile Tyr Val Leu Leu Ile Val Gly Thr Leu Val Cys Gly Ile Val 
        195                 200                 205             


Leu Gly Phe Leu Phe Lys Arg Phe Leu Arg Ile Gln Arg Leu Phe Pro 
    210                 215                 220                 


Pro Val Pro Gln Ile Lys Asp Lys Leu Asn Asp Asn His Glu Val Glu 
225                 230                 235                 240 


Asp Glu Ile Ile Trp Glu Glu Phe Thr Pro Glu Glu Gly Lys Gly Tyr 
                245                 250                 255     


Arg Glu Glu Val Leu Thr Val Lys Glu Ile Thr 
            260                 265         


<210>  3599
<211>  155
<212>  PRT
<213>  Homo Sapiens

<400>  3599

Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr Pro 
            20                  25                  30          


Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 
        35                  40                  45              


Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 
    50                  55                  60                  


Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln 
65                  70                  75                  80  


Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr 
                85                  90                  95      


Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp 
            100                 105                 110         


Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro Thr Gln 
        115                 120                 125             


Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly 
    130                 135                 140                 


Val Leu Val Ala Ser His Leu Gln Ser Phe Leu 
145                 150                 155 


<210>  3600
<211>  204
<212>  PRT
<213>  Homo Sapiens

<400>  3600

Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr Pro 
            20                  25                  30          


Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 
        35                  40                  45              


Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 
    50                  55                  60                  


Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu 
65                  70                  75                  80  


Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser 
                85                  90                  95      


Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu 
            100                 105                 110         


Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu 
        115                 120                 125             


Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala 
    130                 135                 140                 


Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu 
145                 150                 155                 160 


Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg 
                165                 170                 175     


Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu 
            180                 185                 190         


Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
        195                 200                 


<210>  3601
<211>  171
<212>  PRT
<213>  Homo Sapiens

<400>  3601

Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr Pro 
            20                  25                  30          


Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 
        35                  40                  45              


Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 
    50                  55                  60                  


Leu Val Ser Glu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe 
65                  70                  75                  80  


Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu 
                85                  90                  95      


Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr 
            100                 105                 110         


Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln 
        115                 120                 125             


Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg 
    130                 135                 140                 


Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val 
145                 150                 155                 160 


Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
                165                 170     


<210>  3602
<211>  207
<212>  PRT
<213>  Homo Sapiens

<400>  3602

Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr Pro 
            20                  25                  30          


Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 
        35                  40                  45              


Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 
    50                  55                  60                  


Leu Val Ser Glu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 
65                  70                  75                  80  


Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 
                85                  90                  95      


Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 
            100                 105                 110         


Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 
        115                 120                 125             


Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 
    130                 135                 140                 


Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 
145                 150                 155                 160 


Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 
                165                 170                 175     


Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 
            180                 185                 190         


Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
        195                 200                 205         


<210>  3603
<211>  57
<212>  PRT
<213>  Homo Sapiens

<400>  3603

Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Val Cys His 
1               5                   10                  15      


Leu Gln Ala Val Pro Pro Arg Gly Ala Gly Ala Ala Arg Thr Leu Ser 
            20                  25                  30          


Gly His Pro Leu Gly Ser Pro Glu Gln Leu Pro Gln Pro Gly Pro Ala 
        35                  40                  45              


Ala Gly Arg Leu Leu Glu Pro Thr Pro 
    50                  55          


<210>  3604
<211>  164
<212>  PRT
<213>  Homo Sapiens

<400>  3604

Met Ser Pro Glu Pro Ala Leu Ser Pro Ala Leu Gln Leu Leu Leu Trp 
1               5                   10                  15      


His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr Pro Leu Gly Pro Ala 
            20                  25                  30          


Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu Glu Gln Val Arg 
        35                  40                  45              


Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Ala Gly Cys 
    50                  55                  60                  


Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln 
65                  70                  75                  80  


Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu 
                85                  90                  95      


Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu 
            100                 105                 110         


Glu Leu Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro 
        115                 120                 125             


Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala 
    130                 135                 140                 


Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His 
145                 150                 155                 160 


Leu Ala Gln Pro 
                


<210>  3605
<211>  200
<212>  PRT
<213>  Homo Sapiens

<400>  3605

Met Ser Pro Glu Pro Ala Leu Ser Pro Ala Leu Gln Leu Leu Leu Trp 
1               5                   10                  15      


His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr Pro Leu Gly Pro Ala 
            20                  25                  30          


Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu Glu Gln Val Arg 
        35                  40                  45              


Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr 
    50                  55                  60                  


Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu 
65                  70                  75                  80  


Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln 
                85                  90                  95      


Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln 
            100                 105                 110         


Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr 
        115                 120                 125             


Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp 
    130                 135                 140                 


Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro Thr Gln 
145                 150                 155                 160 


Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly 
                165                 170                 175     


Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg 
            180                 185                 190         


Val Leu Arg His Leu Ala Gln Pro 
        195                 200 


<210>  3606
<211>  14
<212>  PRT
<213>  Homo Sapiens

<400>  3606

Met Met Met Val Arg Arg Gly Leu Leu Ala Trp Ile Ser Arg 
1               5                   10                  


<210>  3607
<211>  53
<212>  PRT
<213>  Homo Sapiens

<400>  3607

Met Met Met Val Arg Arg Gly Leu Leu Ala Trp Ile Ser Arg Val Val 
1               5                   10                  15      


Val Leu Leu Val Leu Leu Cys Cys Ala Ile Ser Val Leu Tyr Met Leu 
            20                  25                  30          


Ala Cys Thr Pro Lys Gly Asp Glu Glu Gln Leu Ala Leu Pro Arg Ala 
        35                  40                  45              


Asn Ser Pro Thr Gly 
    50              


<210>  3608
<211>  96
<212>  PRT
<213>  Homo Sapiens

<400>  3608

Met Met Met Val Arg Arg Gly Leu Leu Ala Trp Ile Ser Arg Val Val 
1               5                   10                  15      


Val Leu Leu Val Leu Leu Cys Cys Ala Ile Ser Val Leu Tyr Met Leu 
            20                  25                  30          


Ala Cys Thr Pro Lys Gly Asp Glu Glu Gln Leu Ala Leu Pro Arg Ala 
        35                  40                  45              


Asn Ser Pro Thr Gly Lys Glu Gly Tyr Gln Ala Val Leu Gln Glu Trp 
    50                  55                  60                  


Glu Glu Gln His Arg Asn Tyr Val Ser Ser Leu Lys Arg Gln Ile Ala 
65                  70                  75                  80  


Gln Leu Lys Glu Glu Leu Gln Glu Arg Ser Glu Gln Leu Arg Asn Gly 
                85                  90                  95      


<210>  3609
<211>  104
<212>  PRT
<213>  Homo Sapiens

<400>  3609

Met Met Met Val Arg Arg Gly Leu Leu Ala Trp Ile Ser Arg Val Val 
1               5                   10                  15      


Val Leu Leu Val Leu Leu Cys Cys Ala Ile Ser Val Leu Tyr Met Leu 
            20                  25                  30          


Ala Cys Thr Pro Lys Gly Asp Glu Glu Gln Leu Ala Leu Pro Arg Ala 
        35                  40                  45              


Asn Ser Pro Thr Gly Lys Glu Gly Tyr Gln Ala Val Leu Gln Glu Trp 
    50                  55                  60                  


Glu Glu Gln His Arg Asn Tyr Val Ser Ser Leu Lys Arg Gln Ile Ala 
65                  70                  75                  80  


Gln Leu Lys Glu Glu Leu Gln Glu Arg Ser Glu Gln Leu Arg Asn Gly 
                85                  90                  95      


Gln Tyr Gln Ala Ser Asp Ala Ala 
            100                 


<210>  3610
<211>  532
<212>  PRT
<213>  Homo Sapiens

<400>  3610

Met Met Met Val Arg Arg Gly Leu Leu Ala Trp Ile Ser Arg Val Val 
1               5                   10                  15      


Val Leu Leu Val Leu Leu Cys Cys Ala Ile Ser Val Leu Tyr Met Leu 
            20                  25                  30          


Ala Cys Thr Pro Lys Gly Asp Glu Glu Gln Leu Ala Leu Pro Arg Ala 
        35                  40                  45              


Asn Ser Pro Thr Gly Lys Glu Gly Tyr Gln Ala Val Leu Gln Glu Trp 
    50                  55                  60                  


Glu Glu Gln His Arg Asn Tyr Val Ser Ser Leu Lys Arg Gln Ile Ala 
65                  70                  75                  80  


Gln Leu Lys Glu Glu Leu Gln Glu Arg Ser Glu Gln Leu Arg Asn Gly 
                85                  90                  95      


Gln Tyr Gln Ala Ser Asp Ala Ala Gly Leu Gly Leu Asp Arg Ser Pro 
            100                 105                 110         


Pro Glu Lys Thr Gln Ala Asp Leu Leu Ala Phe Leu His Ser Gln Val 
        115                 120                 125             


Asp Lys Ala Glu Val Asn Ala Gly Val Lys Leu Ala Thr Glu Tyr Ala 
    130                 135                 140                 


Ala Val Pro Phe Asp Ser Phe Thr Leu Gln Lys Val Tyr Gln Leu Glu 
145                 150                 155                 160 


Thr Gly Leu Thr Arg His Pro Glu Glu Lys Pro Val Arg Lys Asp Lys 
                165                 170                 175     


Arg Asp Glu Leu Val Glu Ala Ile Glu Ser Ala Leu Glu Thr Leu Asn 
            180                 185                 190         


Ser Pro Ala Glu Asn Ser Pro Asn His Arg Pro Tyr Thr Ala Ser Asp 
        195                 200                 205             


Phe Ile Glu Gly Ile Tyr Arg Thr Glu Arg Asp Lys Gly Thr Leu Tyr 
    210                 215                 220                 


Glu Leu Thr Phe Lys Gly Asp His Lys His Glu Phe Lys Arg Leu Ile 
225                 230                 235                 240 


Leu Phe Arg Pro Phe Gly Pro Ile Met Lys Val Lys Asn Glu Lys Leu 
                245                 250                 255     


Asn Met Ala Asn Thr Leu Ile Asn Val Ile Val Pro Leu Ala Lys Arg 
            260                 265                 270         


Val Asp Lys Phe Arg Gln Phe Met Gln Asn Phe Arg Glu Met Cys Ile 
        275                 280                 285             


Glu Gln Asp Gly Arg Val His Leu Thr Val Val Tyr Phe Gly Lys Glu 
    290                 295                 300                 


Glu Ile Asn Glu Val Lys Gly Ile Leu Glu Asn Thr Ser Lys Ala Ala 
305                 310                 315                 320 


Asn Phe Arg Asn Phe Thr Phe Ile Gln Leu Asn Gly Glu Phe Ser Arg 
                325                 330                 335     


Gly Lys Gly Leu Asp Val Gly Ala Arg Phe Trp Lys Gly Ser Asn Val 
            340                 345                 350         


Leu Leu Phe Phe Cys Asp Val Asp Ile Tyr Phe Thr Ser Glu Phe Leu 
        355                 360                 365             


Asn Thr Cys Arg Leu Asn Thr Gln Pro Gly Lys Lys Val Phe Tyr Pro 
    370                 375                 380                 


Val Leu Phe Ser Gln Tyr Asn Pro Gly Ile Ile Tyr Gly His His Asp 
385                 390                 395                 400 


Ala Val Pro Pro Leu Glu Gln Gln Leu Val Ile Lys Lys Glu Thr Gly 
                405                 410                 415     


Phe Trp Arg Asp Phe Gly Phe Gly Met Thr Cys Gln Tyr Arg Ser Asp 
            420                 425                 430         


Phe Ile Asn Ile Gly Gly Phe Asp Leu Asp Ile Lys Gly Trp Gly Gly 
        435                 440                 445             


Glu Asp Val His Leu Tyr Arg Lys Tyr Leu His Ser Asn Leu Ile Val 
    450                 455                 460                 


Val Arg Thr Pro Val Arg Gly Leu Phe His Leu Trp His Glu Lys Arg 
465                 470                 475                 480 


Cys Met Asp Glu Leu Thr Pro Glu Gln Tyr Lys Met Cys Met Gln Ser 
                485                 490                 495     


Lys Ala Met Asn Glu Ala Ser His Gly Gln Leu Gly Met Leu Val Phe 
            500                 505                 510         


Arg His Glu Ile Glu Ala His Leu Arg Lys Gln Lys Gln Lys Thr Ser 
        515                 520                 525             


Ser Lys Lys Thr 
    530         


<210>  3611
<211>  297
<212>  PRT
<213>  Homo Sapiens

<400>  3611

Met Met Met Val Arg Arg Gly Leu Leu Ala Trp Ile Ser Arg Val Val 
1               5                   10                  15      


Val Leu Leu Val Leu Leu Cys Cys Ala Ile Ser Val Leu Tyr Met Leu 
            20                  25                  30          


Ala Cys Thr Pro Lys Gly Asp Glu Glu Gln Leu Ala Leu Pro Arg Ala 
        35                  40                  45              


Asn Ser Pro Thr Gly Lys Glu Gly Tyr Gln Ala Val Leu Gln Glu Trp 
    50                  55                  60                  


Glu Glu Gln His Arg Asn Tyr Val Ser Ser Leu Lys Arg Gln Ile Ala 
65                  70                  75                  80  


Gln Leu Lys Glu Glu Leu Gln Glu Arg Ser Glu Gln Leu Arg Asn Gly 
                85                  90                  95      


Gln Tyr Gln Ala Ser Asp Ala Ala Gly Leu Gly Leu Asp Arg Ser Pro 
            100                 105                 110         


Pro Glu Lys Thr Gln Ala Asp Leu Leu Ala Phe Leu His Ser Gln Val 
        115                 120                 125             


Asp Lys Ala Glu Val Asn Ala Gly Val Lys Leu Ala Thr Glu Tyr Ala 
    130                 135                 140                 


Ala Val Pro Phe Asp Ser Phe Thr Leu Gln Lys Val Tyr Gln Leu Glu 
145                 150                 155                 160 


Thr Gly Leu Thr Arg His Pro Glu Glu Lys Pro Val Arg Lys Asp Lys 
                165                 170                 175     


Arg Asp Glu Leu Val Glu Ala Ile Glu Ser Ala Leu Glu Thr Leu Asn 
            180                 185                 190         


Ser Pro Ala Glu Asn Ser Pro Asn His Arg Pro Tyr Thr Ala Ser Asp 
        195                 200                 205             


Phe Ile Glu Gly Ile Tyr Arg Thr Glu Arg Asp Lys Gly Thr Leu Tyr 
    210                 215                 220                 


Glu Leu Thr Phe Lys Gly Asp His Lys His Glu Phe Lys Arg Leu Ile 
225                 230                 235                 240 


Leu Phe Arg Pro Phe Gly Pro Ile Met Lys Val Lys Asn Glu Lys Leu 
                245                 250                 255     


Asn Met Ala Asn Thr Leu Ile Asn Val Ile Val Pro Leu Ala Lys Arg 
            260                 265                 270         


Val Asp Lys Phe Arg Gln Phe Met Gln Asn Phe Arg Pro Ala Asp Glu 
        275                 280                 285             


Val Phe Arg Cys Val Pro Leu Ser Pro 
    290                 295         


<210>  3612
<211>  297
<212>  PRT
<213>  Homo Sapiens

<400>  3612

Met Met Met Val Arg Arg Gly Leu Leu Ala Trp Ile Ser Arg Val Val 
1               5                   10                  15      


Val Leu Leu Val Leu Leu Cys Cys Ala Ile Ser Val Leu Tyr Met Leu 
            20                  25                  30          


Ala Cys Thr Pro Lys Gly Asp Glu Glu Gln Leu Ala Leu Pro Arg Ala 
        35                  40                  45              


Asn Ser Pro Thr Gly Lys Glu Gly Tyr Gln Ala Val Leu Gln Glu Trp 
    50                  55                  60                  


Glu Glu Gln His Arg Asn Tyr Val Ser Ser Leu Lys Arg Gln Ile Ala 
65                  70                  75                  80  


Gln Leu Lys Glu Glu Leu Gln Glu Arg Ser Glu Gln Leu Arg Asn Gly 
                85                  90                  95      


Gln Tyr Gln Ala Ser Asp Ala Ala Gly Leu Gly Leu Asp Arg Ser Pro 
            100                 105                 110         


Pro Glu Lys Thr Gln Ala Asp Leu Leu Ala Phe Leu His Ser Gln Val 
        115                 120                 125             


Asp Lys Ala Glu Val Asn Ala Gly Val Lys Leu Ala Thr Glu Tyr Ala 
    130                 135                 140                 


Ala Val Pro Phe Asp Ser Phe Thr Leu Gln Lys Val Tyr Gln Leu Glu 
145                 150                 155                 160 


Thr Gly Leu Thr Arg His Pro Glu Glu Lys Pro Val Arg Lys Asp Lys 
                165                 170                 175     


Arg Asp Glu Leu Val Glu Ala Ile Glu Ser Ala Leu Glu Thr Leu Asn 
            180                 185                 190         


Ser Pro Ala Glu Asn Ser Pro Asn His Arg Pro Tyr Thr Ala Ser Asp 
        195                 200                 205             


Phe Ile Glu Gly Ile Tyr Arg Thr Glu Arg Asp Lys Gly Thr Leu Tyr 
    210                 215                 220                 


Glu Leu Thr Phe Lys Gly Asp His Lys His Glu Phe Lys Arg Leu Ile 
225                 230                 235                 240 


Leu Phe Arg Pro Phe Gly Pro Ile Met Lys Val Lys Asn Glu Lys Leu 
                245                 250                 255     


Asn Met Ala Asn Thr Leu Ile Asn Val Ile Val Pro Leu Ala Lys Arg 
            260                 265                 270         


Val Asp Lys Phe Arg Gln Phe Met Gln Asn Phe Arg Pro Ala Asp Glu 
        275                 280                 285             


Val Phe Arg Cys Val Pro Leu Ser Pro 
    290                 295         


<210>  3613
<211>  532
<212>  PRT
<213>  Homo Sapiens

<400>  3613

Met Met Met Val Arg Arg Gly Leu Leu Ala Trp Ile Ser Arg Val Val 
1               5                   10                  15      


Val Leu Leu Val Leu Leu Cys Cys Ala Ile Ser Val Leu Tyr Met Leu 
            20                  25                  30          


Ala Cys Thr Pro Lys Gly Asp Glu Glu Gln Leu Ala Leu Pro Arg Ala 
        35                  40                  45              


Asn Ser Pro Thr Gly Lys Glu Gly Tyr Gln Ala Val Leu Gln Glu Trp 
    50                  55                  60                  


Glu Glu Gln His Arg Asn Tyr Val Ser Ser Leu Lys Arg Gln Ile Ala 
65                  70                  75                  80  


Gln Leu Lys Glu Glu Leu Gln Glu Arg Ser Glu Gln Leu Arg Asn Gly 
                85                  90                  95      


Gln Tyr Gln Ala Ser Asp Ala Ala Gly Leu Gly Leu Asp Arg Ser Pro 
            100                 105                 110         


Pro Glu Lys Thr Gln Ala Asp Leu Leu Ala Phe Leu His Ser Gln Val 
        115                 120                 125             


Asp Lys Ala Glu Val Asn Ala Gly Val Lys Leu Ala Thr Glu Tyr Ala 
    130                 135                 140                 


Ala Val Pro Phe Asp Ser Phe Thr Leu Gln Lys Val Tyr Gln Leu Glu 
145                 150                 155                 160 


Thr Gly Leu Thr Arg His Pro Glu Glu Lys Pro Val Arg Lys Asp Lys 
                165                 170                 175     


Arg Asp Glu Leu Val Glu Ala Ile Glu Ser Ala Leu Glu Thr Leu Asn 
            180                 185                 190         


Ser Pro Ala Glu Asn Ser Pro Asn His Arg Pro Tyr Thr Ala Ser Asp 
        195                 200                 205             


Phe Ile Glu Gly Ile Tyr Arg Thr Glu Arg Asp Lys Gly Thr Leu Tyr 
    210                 215                 220                 


Glu Leu Thr Phe Lys Gly Asp His Lys His Glu Phe Lys Arg Leu Ile 
225                 230                 235                 240 


Leu Phe Arg Pro Phe Gly Pro Ile Met Lys Val Lys Asn Glu Lys Leu 
                245                 250                 255     


Asn Met Ala Asn Thr Leu Ile Asn Val Ile Val Pro Leu Ala Lys Arg 
            260                 265                 270         


Val Asp Lys Phe Arg Gln Phe Met Gln Asn Phe Arg Glu Met Cys Ile 
        275                 280                 285             


Glu Gln Asp Gly Arg Val His Leu Thr Val Val Tyr Phe Gly Lys Glu 
    290                 295                 300                 


Glu Ile Asn Glu Val Lys Gly Ile Leu Glu Asn Thr Ser Lys Ala Ala 
305                 310                 315                 320 


Asn Phe Arg Asn Phe Thr Phe Ile Gln Leu Asn Gly Glu Phe Ser Arg 
                325                 330                 335     


Gly Lys Gly Leu Asp Val Gly Ala Arg Phe Trp Lys Gly Ser Asn Val 
            340                 345                 350         


Leu Leu Phe Phe Cys Asp Val Asp Ile Tyr Phe Thr Ser Glu Phe Leu 
        355                 360                 365             


Asn Thr Cys Arg Leu Asn Thr Gln Pro Gly Lys Lys Val Phe Tyr Pro 
    370                 375                 380                 


Val Leu Phe Ser Gln Tyr Asn Pro Gly Ile Ile Tyr Gly His His Asp 
385                 390                 395                 400 


Ala Val Pro Pro Leu Glu Gln Gln Leu Val Ile Lys Lys Glu Thr Gly 
                405                 410                 415     


Phe Trp Arg Asp Phe Gly Phe Gly Met Thr Cys Gln Tyr Arg Ser Asp 
            420                 425                 430         


Phe Ile Asn Ile Gly Gly Phe Asp Leu Asp Ile Lys Gly Trp Gly Gly 
        435                 440                 445             


Glu Asp Val His Leu Tyr Arg Lys Tyr Leu His Ser Asn Leu Ile Val 
    450                 455                 460                 


Val Arg Thr Pro Val Arg Gly Leu Phe His Leu Trp His Glu Lys Arg 
465                 470                 475                 480 


Cys Met Asp Glu Leu Thr Pro Glu Gln Tyr Lys Met Cys Met Gln Ser 
                485                 490                 495     


Lys Ala Met Asn Glu Ala Ser His Gly Gln Leu Gly Met Leu Val Phe 
            500                 505                 510         


Arg His Glu Ile Glu Ala His Leu Arg Lys Gln Lys Gln Lys Thr Ser 
        515                 520                 525             


Ser Lys Lys Thr 
    530         


<210>  3614
<211>  532
<212>  PRT
<213>  Homo Sapiens

<400>  3614

Met Met Met Val Arg Arg Gly Leu Leu Ala Trp Ile Ser Arg Val Val 
1               5                   10                  15      


Val Leu Leu Val Leu Leu Cys Cys Ala Ile Ser Val Leu Tyr Met Leu 
            20                  25                  30          


Ala Cys Thr Pro Lys Gly Asp Glu Glu Gln Leu Ala Leu Pro Arg Ala 
        35                  40                  45              


Asn Ser Pro Thr Gly Lys Glu Gly Tyr Gln Ala Val Leu Gln Glu Trp 
    50                  55                  60                  


Glu Glu Gln His Arg Asn Tyr Val Ser Ser Leu Lys Arg Gln Ile Ala 
65                  70                  75                  80  


Gln Leu Lys Glu Glu Leu Gln Glu Arg Ser Glu Gln Leu Arg Asn Gly 
                85                  90                  95      


Gln Tyr Gln Ala Ser Asp Ala Ala Gly Leu Gly Leu Asp Arg Ser Pro 
            100                 105                 110         


Pro Glu Lys Thr Gln Ala Asp Leu Leu Ala Phe Leu His Ser Gln Val 
        115                 120                 125             


Asp Lys Ala Glu Val Asn Ala Gly Val Lys Leu Ala Thr Glu Tyr Ala 
    130                 135                 140                 


Ala Val Pro Phe Asp Ser Phe Thr Leu Gln Lys Val Tyr Gln Leu Glu 
145                 150                 155                 160 


Thr Gly Leu Thr Arg His Pro Glu Glu Lys Pro Val Arg Lys Asp Lys 
                165                 170                 175     


Arg Asp Glu Leu Val Glu Ala Ile Glu Ser Ala Leu Glu Thr Leu Asn 
            180                 185                 190         


Ser Pro Ala Glu Asn Ser Pro Asn His Arg Pro Tyr Thr Ala Ser Asp 
        195                 200                 205             


Phe Ile Glu Gly Ile Tyr Arg Thr Glu Arg Asp Lys Gly Thr Leu Tyr 
    210                 215                 220                 


Glu Leu Thr Phe Lys Gly Asp His Lys His Glu Phe Lys Arg Leu Ile 
225                 230                 235                 240 


Leu Phe Arg Pro Phe Gly Pro Ile Met Lys Val Lys Asn Glu Lys Leu 
                245                 250                 255     


Asn Met Ala Asn Thr Leu Ile Asn Val Ile Val Pro Leu Ala Lys Arg 
            260                 265                 270         


Val Asp Lys Phe Arg Gln Phe Met Gln Asn Phe Arg Glu Met Cys Ile 
        275                 280                 285             


Glu Gln Asp Gly Arg Val His Leu Thr Val Val Tyr Phe Gly Lys Glu 
    290                 295                 300                 


Glu Ile Asn Glu Val Lys Gly Ile Leu Glu Asn Thr Ser Lys Ala Ala 
305                 310                 315                 320 


Asn Phe Arg Asn Phe Thr Phe Ile Gln Leu Asn Gly Glu Phe Ser Arg 
                325                 330                 335     


Gly Lys Gly Leu Asp Val Gly Ala Arg Phe Trp Lys Gly Ser Asn Val 
            340                 345                 350         


Leu Leu Phe Phe Cys Asp Val Asp Ile Tyr Phe Thr Ser Glu Phe Leu 
        355                 360                 365             


Asn Thr Cys Arg Leu Asn Thr Gln Pro Gly Lys Lys Val Phe Tyr Pro 
    370                 375                 380                 


Val Leu Phe Ser Gln Tyr Asn Pro Gly Ile Ile Tyr Gly His His Asp 
385                 390                 395                 400 


Ala Val Pro Pro Leu Glu Gln Gln Leu Val Ile Lys Lys Glu Thr Gly 
                405                 410                 415     


Phe Trp Arg Asp Phe Gly Phe Gly Met Thr Cys Gln Tyr Arg Ser Asp 
            420                 425                 430         


Phe Ile Asn Ile Gly Gly Phe Asp Leu Asp Ile Lys Gly Trp Gly Gly 
        435                 440                 445             


Glu Asp Val His Leu Tyr Arg Lys Tyr Leu His Ser Asn Leu Ile Val 
    450                 455                 460                 


Val Arg Thr Pro Val Arg Gly Leu Phe His Leu Trp His Glu Lys Arg 
465                 470                 475                 480 


Cys Met Asp Glu Leu Thr Pro Glu Gln Tyr Lys Met Cys Met Gln Ser 
                485                 490                 495     


Lys Ala Met Asn Glu Ala Ser His Gly Gln Leu Gly Met Leu Val Phe 
            500                 505                 510         


Arg His Glu Ile Glu Ala His Leu Arg Lys Gln Lys Gln Lys Thr Ser 
        515                 520                 525             


Ser Lys Lys Thr 
    530         


<210>  3615
<211>  217
<212>  PRT
<213>  Homo Sapiens

<400>  3615

Met Ala Pro Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Ala Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala Val Gln Thr Val Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp His Ala Met Leu Gln Ala His Arg Ala His Gln 
        35                  40                  45              


Leu Ala Ile Asp Thr Tyr Gln Glu Phe Glu Glu Thr Tyr Ile Pro Lys 
    50                  55                  60                  


Asp Gln Lys Tyr Ser Phe Leu His Asp Ser Gln Thr Ser Phe Cys Phe 
65                  70                  75                  80  


Ser Asp Ser Ile Pro Thr Pro Ser Asn Met Glu Glu Thr Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Glu Ser Trp 
            100                 105                 110         


Leu Glu Pro Val Arg Phe Leu Arg Ser Met Phe Ala Asn Asn Leu Val 
        115                 120                 125             


Tyr Asp Thr Ser Asp Ser Asp Asp Tyr His Leu Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Arg Arg 
145                 150                 155                 160 


Thr Gly Gln Ile Leu Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser 
                165                 170                 175     


His Asn His Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe 
            180                 185                 190         


Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Met Val Gln Cys 
        195                 200                 205             


Arg Ser Val Glu Gly Ser Cys Gly Phe 
    210                 215         


<210>  3616
<211>  256
<212>  PRT
<213>  Homo Sapiens

<400>  3616

Met Ala Pro Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Ala Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala Val Gln Thr Val Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp His Ala Met Leu Gln Ala His Arg Ala His Gln 
        35                  40                  45              


Leu Ala Ile Asp Thr Tyr Gln Glu Phe Glu Glu Thr Tyr Ile Pro Lys 
    50                  55                  60                  


Asp Gln Lys Tyr Ser Phe Leu His Asp Ser Gln Thr Ser Phe Cys Phe 
65                  70                  75                  80  


Ser Asp Ser Ile Pro Thr Pro Ser Asn Met Glu Glu Thr Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Glu Ser Trp 
            100                 105                 110         


Leu Glu Pro Val Arg Phe Leu Arg Ser Met Phe Ala Asn Asn Leu Val 
        115                 120                 125             


Tyr Asp Thr Ser Asp Ser Asp Asp Tyr His Leu Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Thr Leu Met Gly Val Arg Val Ala Pro Gly Val Thr 
145                 150                 155                 160 


Asn Pro Gly Thr Pro Leu Ala Ser Arg Ala Gly Gly Glu Lys Tyr Cys 
                165                 170                 175     


Cys Pro Leu Phe Ser Ser Lys Ala Leu Thr Gln Glu Asn Ser Pro Tyr 
            180                 185                 190         


Ser Ser Phe Arg Leu Val Asn Pro Pro Gly Leu Ser Leu His Pro Glu 
        195                 200                 205             


Gly Glu Gly Gly Lys Trp Ile Asn Glu Arg Gly Arg Glu Gln Cys Pro 
    210                 215                 220                 


Ser Ala Trp Pro Leu Leu Leu Phe Leu His Phe Ala Glu Ala Gly Arg 
225                 230                 235                 240 


Arg Gln Pro Pro Asp Trp Ala Asp Pro Gln Ala Asp Leu Gln Gln Val 
                245                 250                 255     


<210>  3617
<211>  122
<212>  PRT
<213>  Homo Sapiens

<400>  3617

Met Ala Pro Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Ala Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala Val Gln Thr Val Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp His Ala Met Leu Gln Ala His Arg Ala His Gln 
        35                  40                  45              


Leu Ala Ile Asp Thr Tyr Gln Glu Phe Arg Leu Glu Asp Gly Ser Arg 
    50                  55                  60                  


Arg Thr Gly Gln Ile Leu Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn 
65                  70                  75                  80  


Ser His Asn His Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys 
                85                  90                  95      


Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Met Val Gln 
            100                 105                 110         


Cys Arg Ser Val Glu Gly Ser Cys Gly Phe 
        115                 120         


<210>  3618
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  3618

Met Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser 
1               5                   10                  15      


Leu Leu Leu Ile Glu Ser Trp Leu Glu Pro Val Arg Phe Leu Arg Ser 
            20                  25                  30          


Met Phe Ala Asn Asn Leu Val Tyr Asp Thr Ser Asp Ser Asp Asp Tyr 
        35                  40                  45              


His Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg 
    50                  55                  60                  


Leu Glu Asp Gly Ser Arg Arg Thr Gly Gln Ile Leu Lys Gln Thr Tyr 
65                  70                  75                  80  


Ser Lys Phe Asp Thr Asn Ser His Asn His Asp Ala Leu Leu Lys Asn 
                85                  90                  95      


Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr 
            100                 105                 110         


Phe Leu Arg Met Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe 
        115                 120                 125             


<210>  3619
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  3619

Met Ala Ala Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Ala Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Ala Asp Ser Ile Pro Thr Pro Ser Asn 
            20                  25                  30          


Met Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser 
        35                  40                  45              


Leu Leu Leu Ile Glu Ser Trp Leu Glu Pro Val Arg Phe Leu Arg Ser 
    50                  55                  60                  


Met Phe Ala Asn Asn Leu Val Tyr Asp Thr Ser Asp Ser Asp Asp Tyr 
65                  70                  75                  80  


His Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg 
                85                  90                  95      


Leu Glu Asp Gly Ser Arg Arg Thr Gly Gln Ile Leu Lys Gln Thr Tyr 
            100                 105                 110         


Ser Lys Phe Asp Thr Asn Ser His Asn His Asp Ala Leu Leu Lys Asn 
        115                 120                 125             


Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr 
    130                 135                 140                 


Phe Leu Arg Met Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe 
145                 150                 155                 160 


<210>  3620
<211>  217
<212>  PRT
<213>  Homo Sapiens

<400>  3620

Met Ala Ala Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Ala Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala Val Gln Thr Val Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp His Ala Met Leu Gln Ala His Arg Ala His Gln 
        35                  40                  45              


Leu Ala Ile Asp Thr Tyr Gln Glu Phe Glu Glu Thr Tyr Ile Pro Lys 
    50                  55                  60                  


Asp Gln Lys Tyr Ser Phe Leu His Asp Ser Gln Thr Ser Phe Cys Phe 
65                  70                  75                  80  


Ser Asp Ser Ile Pro Thr Pro Ser Asn Met Glu Glu Thr Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Glu Ser Trp 
            100                 105                 110         


Leu Glu Pro Val Arg Phe Leu Arg Ser Met Phe Ala Asn Asn Leu Val 
        115                 120                 125             


Tyr Asp Thr Ser Asp Ser Asp Asp Tyr His Leu Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Arg Arg 
145                 150                 155                 160 


Thr Gly Gln Ile Leu Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser 
                165                 170                 175     


His Asn His Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe 
            180                 185                 190         


Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Met Val Gln Cys 
        195                 200                 205             


Arg Ser Val Glu Gly Ser Cys Gly Phe 
    210                 215         


<210>  3621
<211>  167
<212>  PRT
<213>  Homo Sapiens

<400>  3621

Met Ala Ala Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Ala Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala Val Gln Thr Val Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp His Ala Met Leu Gln Ala His Arg Ala His Gln 
        35                  40                  45              


Leu Ala Ile Asp Thr Tyr Gln Glu Phe Glu Glu Thr Tyr Ile Pro Lys 
    50                  55                  60                  


Asp Gln Lys Tyr Ser Phe Leu His Asp Ser Gln Thr Ser Phe Cys Phe 
65                  70                  75                  80  


Ser Asp Ser Ile Pro Thr Pro Ser Asn Met Glu Glu Thr Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Glu Ser Trp 
            100                 105                 110         


Leu Glu Pro Val Arg Phe Leu Arg Ser Met Phe Ala Asn Asn Leu Val 
        115                 120                 125             


Tyr Asp Thr Ser Asp Ser Asp Asp Tyr His Leu Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Thr Leu Met Gly Val Arg Val Ala Pro Gly Val Ala 
145                 150                 155                 160 


Asn Pro Gly Thr Pro Leu Ala 
                165         


<210>  3622
<211>  122
<212>  PRT
<213>  Homo Sapiens

<400>  3622

Met Ala Ala Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Ala Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala Val Gln Thr Val Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp His Ala Met Leu Gln Ala His Arg Ala His Gln 
        35                  40                  45              


Leu Ala Ile Asp Thr Tyr Gln Glu Phe Arg Leu Glu Asp Gly Ser Arg 
    50                  55                  60                  


Arg Thr Gly Gln Ile Leu Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn 
65                  70                  75                  80  


Ser His Asn His Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys 
                85                  90                  95      


Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Met Val Gln 
            100                 105                 110         


Cys Arg Ser Val Glu Gly Ser Cys Gly Phe 
        115                 120         


<210>  3623
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  3623

Met Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser 
1               5                   10                  15      


Leu Leu Leu Ile Glu Ser Trp Leu Glu Pro Val Arg Phe Leu Arg Ser 
            20                  25                  30          


Met Phe Ala Asn Asn Leu Val Tyr Asp Thr Ser Asp Ser Asp Asp Tyr 
        35                  40                  45              


His Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg 
    50                  55                  60                  


Leu Glu Asp Gly Ser Arg Arg Thr Gly Gln Ile Leu Lys Gln Thr Tyr 
65                  70                  75                  80  


Ser Lys Phe Asp Thr Asn Ser His Asn His Asp Ala Leu Leu Lys Asn 
                85                  90                  95      


Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr 
            100                 105                 110         


Phe Leu Arg Met Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe 
        115                 120                 125             


<210>  3624
<211>  139
<212>  PRT
<213>  Homo Sapiens

<400>  3624

Met Ala Ala Asp Ser Ile Pro Thr Ser Ser Asn Met Glu Glu Thr Gln 
1               5                   10                  15      


Gln Lys Ser Asn Leu Glu Leu Leu His Ile Ser Leu Leu Leu Ile Glu 
            20                  25                  30          


Ser Arg Leu Glu Pro Val Arg Phe Leu Arg Ser Thr Phe Thr Asn Asn 
        35                  40                  45              


Leu Val Tyr Asp Thr Ser Asp Ser Asp Asp Tyr His Leu Leu Lys Asp 
    50                  55                  60                  


Leu Glu Glu Gly Ile Gln Met Leu Met Gly Arg Leu Glu Asp Gly Ser 
65                  70                  75                  80  


His Leu Thr Gly Gln Thr Leu Lys Gln Thr Tyr Ser Lys Phe Asp Thr 
                85                  90                  95      


Asn Ser His Asn His Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu His 
            100                 105                 110         


Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Met Val 
        115                 120                 125             


Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe 
    130                 135                 


<210>  3625
<211>  178
<212>  PRT
<213>  Homo Sapiens

<400>  3625

Met Ala Ala Asp Ser Ile Pro Thr Ser Ser Asn Met Glu Glu Thr Gln 
1               5                   10                  15      


Gln Lys Ser Asn Leu Glu Leu Leu His Ile Ser Leu Leu Leu Ile Glu 
            20                  25                  30          


Ser Arg Leu Glu Pro Val Arg Phe Leu Arg Ser Thr Phe Thr Asn Asn 
        35                  40                  45              


Leu Val Tyr Asp Thr Ser Asp Ser Asp Asp Tyr His Leu Leu Lys Asp 
    50                  55                  60                  


Leu Glu Glu Gly Ile Gln Met Leu Met Gly Val Arg Val Ala Pro Gly 
65                  70                  75                  80  


Val Pro Asn Pro Gly Ser Pro Leu Ala Ser Arg Ala Gly Gly Glu Lys 
                85                  90                  95      


His Cys Cys Pro Leu Phe Ser Ser Gln Ala Leu Thr Gln Glu Asn Ser 
            100                 105                 110         


Pro Tyr Ser Ser Phe Pro Leu Val Asn Pro Pro Gly Leu Ser Leu His 
        115                 120                 125             


Pro Glu Gly Glu Gly Gly Lys Trp Ile Asn Glu Arg Gly Arg Glu Gln 
    130                 135                 140                 


Cys Pro Ser Ala Trp Ser Leu Leu Leu Leu Leu His Phe Ala Glu Ala 
145                 150                 155                 160 


Gly Arg Arg Gln Pro Pro Asp Trp Ala Asp Pro Gln Ala Asp Leu Gln 
                165                 170                 175     


Gln Val 
        


<210>  3626
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  3626

Met Ala Ala Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Ala Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Ala Asp Ser Ile Pro Thr Ser Ser Asn 
            20                  25                  30          


Met Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu His Ile Ser 
        35                  40                  45              


Leu Leu Leu Ile Glu Ser Arg Leu Glu Pro Val Arg Phe Leu Arg Ser 
    50                  55                  60                  


Thr Phe Thr Asn Asn Leu Val Tyr Asp Thr Ser Asp Ser Asp Asp Tyr 
65                  70                  75                  80  


His Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Met Leu Met Gly Arg 
                85                  90                  95      


Leu Glu Asp Gly Ser His Leu Thr Gly Gln Thr Leu Lys Gln Thr Tyr 
            100                 105                 110         


Ser Lys Phe Asp Thr Asn Ser His Asn His Asp Ala Leu Leu Lys Asn 
        115                 120                 125             


Tyr Gly Leu Leu His Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr 
    130                 135                 140                 


Phe Leu Arg Met Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe 
145                 150                 155                 160 


<210>  3627
<211>  222
<212>  PRT
<213>  Homo Sapiens

<400>  3627

Met Ala Ala Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Ala Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala Val Gln Thr Val Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Lys Glu Ala Met Leu Gln Ala His Arg Ala His Gln 
        35                  40                  45              


Leu Ala Ile Asp Thr Tyr Gln Glu Phe Ile Ser Ser Trp Gly Met Glu 
    50                  55                  60                  


Ala Tyr Ile Thr Lys Glu Gln Lys Tyr Ser Phe Leu His Asp Ser Gln 
65                  70                  75                  80  


Thr Ser Phe Cys Phe Ser Asp Ser Ile Pro Thr Ser Ser Asn Met Glu 
                85                  90                  95      


Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu His Ile Ser Leu Leu 
            100                 105                 110         


Leu Ile Glu Ser Arg Leu Glu Pro Val Arg Phe Leu Arg Ser Thr Phe 
        115                 120                 125             


Thr Asn Asn Leu Val Tyr Asp Thr Ser Asp Ser Asp Asp Tyr His Leu 
    130                 135                 140                 


Leu Lys Asp Leu Glu Glu Gly Ile Gln Met Leu Met Gly Arg Leu Glu 
145                 150                 155                 160 


Asp Gly Ser His Leu Thr Gly Gln Thr Leu Lys Gln Thr Tyr Ser Lys 
                165                 170                 175     


Phe Asp Thr Asn Ser His Asn His Asp Ala Leu Leu Lys Asn Tyr Gly 
            180                 185                 190         


Leu Leu His Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu 
        195                 200                 205             


Arg Met Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe 
    210                 215                 220         


<210>  3628
<211>  217
<212>  PRT
<213>  Homo Sapiens

<400>  3628

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Ala Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala Val Gln Thr Val Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Lys Glu Ala Met Leu Gln Ala His Arg Ala His Gln 
        35                  40                  45              


Leu Ala Ile Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Thr Lys 
    50                  55                  60                  


Glu Gln Lys Tyr Ser Phe Leu His Asp Ser Gln Thr Ser Phe Cys Phe 
65                  70                  75                  80  


Ser Asp Ser Ile Pro Thr Ser Ser Asn Met Glu Glu Thr Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu His Ile Ser Leu Leu Leu Ile Glu Ser Arg 
            100                 105                 110         


Leu Glu Pro Val Arg Phe Leu Arg Ser Thr Phe Thr Asn Asn Leu Val 
        115                 120                 125             


Tyr Asp Thr Ser Asp Ser Asp Asp Tyr His Leu Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Met Leu Met Gly Arg Leu Glu Asp Gly Ser His Leu 
145                 150                 155                 160 


Thr Gly Gln Thr Leu Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser 
                165                 170                 175     


His Asn His Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu His Cys Phe 
            180                 185                 190         


Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Met Val Gln Cys 
        195                 200                 205             


Arg Ser Val Glu Gly Ser Cys Gly Phe 
    210                 215         


<210>  3629
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  3629

Met Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu His Ile Ser 
1               5                   10                  15      


Leu Leu Leu Ile Glu Ser Arg Leu Glu Pro Val Arg Phe Leu Arg Ser 
            20                  25                  30          


Thr Phe Thr Asn Asn Leu Val Tyr Asp Thr Ser Asp Ser Asp Asp Tyr 
        35                  40                  45              


His Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Met Leu Met Gly Arg 
    50                  55                  60                  


Leu Glu Asp Gly Ser His Leu Thr Gly Gln Thr Leu Lys Gln Thr Tyr 
65                  70                  75                  80  


Ser Lys Phe Asp Thr Asn Ser His Asn His Asp Ala Leu Leu Lys Asn 
                85                  90                  95      


Tyr Gly Leu Leu His Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr 
            100                 105                 110         


Phe Leu Arg Met Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe 
        115                 120                 125             


<210>  3630
<211>  167
<212>  PRT
<213>  Homo Sapiens

<400>  3630

Met Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu His Ile Ser 
1               5                   10                  15      


Leu Leu Leu Ile Glu Ser Arg Leu Glu Pro Val Arg Phe Leu Arg Ser 
            20                  25                  30          


Thr Phe Thr Asn Asn Leu Val Tyr Asp Thr Ser Asp Ser Asp Asp Tyr 
        35                  40                  45              


His Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Met Leu Met Gly Val 
    50                  55                  60                  


Arg Val Ala Pro Gly Val Pro Asn Pro Gly Ser Pro Leu Ala Ser Arg 
65                  70                  75                  80  


Ala Gly Gly Glu Lys His Cys Cys Pro Leu Phe Ser Ser Gln Ala Leu 
                85                  90                  95      


Thr Gln Glu Asn Ser Pro Tyr Ser Ser Phe Pro Leu Val Asn Pro Pro 
            100                 105                 110         


Gly Leu Ser Leu His Pro Glu Gly Glu Gly Gly Lys Trp Ile Asn Glu 
        115                 120                 125             


Arg Gly Arg Glu Gln Cys Pro Ser Ala Trp Ser Leu Leu Leu Leu Leu 
    130                 135                 140                 


His Phe Ala Glu Ala Gly Arg Arg Gln Pro Pro Asp Trp Ala Asp Pro 
145                 150                 155                 160 


Gln Ala Asp Leu Gln Gln Val 
                165         


<210>  3631
<211>  76
<212>  PRT
<213>  Homo Sapiens

<400>  3631

Lys Met Glu Ser Ser Ile Ser Ser Ser Ser Glu Glu Gln Ile Arg Arg 
1               5                   10                  15      


Met Asn Glu Asn Ser His Val Gln Val Pro Phe Gln Gln Leu Asn Gln 
            20                  25                  30          


Leu Ala Ala Tyr Pro Tyr Ala Val Trp Tyr Tyr Pro Gln Ile Met Gln 
        35                  40                  45              


Tyr Val Pro Phe Pro Pro Phe Ser Asp Ile Ser Asn Pro Thr Ala His 
    50                  55                  60                  


Glu Asn Tyr Glu Lys Asn Asn Val Met Leu Gln Trp 
65                  70                  75      


<210>  3632
<211>  185
<212>  PRT
<213>  Homo Sapiens

<400>  3632

Met Arg Leu Leu Ile Leu Thr Cys Leu Val Ala Val Ala Leu Ala Arg 
1               5                   10                  15      


Pro Lys Leu Pro Leu Arg Tyr Pro Glu Arg Leu Gln Asn Pro Ser Glu 
            20                  25                  30          


Ser Ser Glu Pro Ile Pro Leu Glu Ser Arg Glu Glu Tyr Met Asn Gly 
        35                  40                  45              


Met Asn Arg Gln Arg Asn Ile Leu Arg Glu Lys Gln Thr Asp Glu Ile 
    50                  55                  60                  


Lys Asp Thr Arg Asn Glu Ser Thr Gln Asn Cys Val Val Ala Glu Pro 
65                  70                  75                  80  


Glu Lys Met Glu Ser Ser Ile Ser Ser Ser Ser Glu Glu Met Ser Leu 
                85                  90                  95      


Ser Lys Cys Ala Glu Gln Phe Cys Arg Leu Asn Glu Tyr Asn Gln Leu 
            100                 105                 110         


Gln Leu Gln Ala Ala His Ala Gln Glu Gln Ile Arg Arg Met Asn Glu 
        115                 120                 125             


Asn Ser His Val Gln Val Pro Phe Gln Gln Leu Asn Gln Leu Ala Ala 
    130                 135                 140                 


Tyr Pro Tyr Ala Val Trp Tyr Tyr Pro Gln Ile Met Gln Tyr Val Pro 
145                 150                 155                 160 


Phe Pro Pro Phe Ser Asp Ile Ser Asn Pro Thr Ala His Glu Asn Tyr 
                165                 170                 175     


Glu Lys Asn Asn Val Met Leu Gln Trp 
            180                 185 


<210>  3633
<211>  177
<212>  PRT
<213>  Homo Sapiens

<400>  3633

Met Arg Leu Leu Ile Leu Thr Cys Leu Val Ala Val Ala Leu Ala Arg 
1               5                   10                  15      


Pro Lys Leu Pro Leu Arg Tyr Pro Glu Arg Leu Gln Asn Pro Ser Glu 
            20                  25                  30          


Ser Ser Glu Pro Ile Pro Leu Glu Ser Arg Glu Glu Tyr Met Asn Gly 
        35                  40                  45              


Met Asn Arg Gln Arg Asn Ile Leu Arg Glu Lys Gln Thr Asp Glu Ile 
    50                  55                  60                  


Lys Asp Thr Arg Asn Glu Ser Thr Gln Asn Cys Val Val Ala Glu Pro 
65                  70                  75                  80  


Glu Lys Met Glu Ser Ser Ile Ser Ser Ser Ser Glu Glu Gln Phe Cys 
                85                  90                  95      


Arg Leu Asn Glu Tyr Asn Gln Leu Gln Leu Gln Ala Ala His Ala Gln 
            100                 105                 110         


Glu Gln Ile Arg Arg Met Asn Glu Asn Ser His Val Gln Val Pro Phe 
        115                 120                 125             


Gln Gln Leu Asn Gln Leu Ala Ala Tyr Pro Tyr Ala Val Trp Tyr Tyr 
    130                 135                 140                 


Pro Gln Ile Met Gln Tyr Val Pro Phe Pro Pro Phe Ser Asp Ile Ser 
145                 150                 155                 160 


Asn Pro Thr Ala His Glu Asn Tyr Glu Lys Asn Asn Val Met Leu Gln 
                165                 170                 175     


Trp 
    


<210>  3634
<211>  169
<212>  PRT
<213>  Homo Sapiens

<400>  3634

Met Arg Leu Leu Ile Leu Thr Cys Leu Val Ala Val Ala Leu Ala Arg 
1               5                   10                  15      


Pro Lys Leu Pro Leu Arg Tyr Pro Glu Arg Leu Gln Asn Pro Ser Glu 
            20                  25                  30          


Ser Ser Glu Pro Ile Pro Leu Glu Ser Arg Glu Glu Tyr Met Asn Gly 
        35                  40                  45              


Met Asn Arg Gln Arg Asn Ile Leu Arg Glu Lys Gln Thr Asp Glu Ile 
    50                  55                  60                  


Lys Asn Cys Val Val Ala Glu Pro Glu Lys Met Glu Ser Ser Ile Ser 
65                  70                  75                  80  


Ser Ser Ser Glu Glu Gln Phe Cys Arg Leu Asn Glu Tyr Asn Gln Leu 
                85                  90                  95      


Gln Leu Gln Ala Ala His Ala Gln Glu Gln Ile Arg Arg Met Asn Glu 
            100                 105                 110         


Asn Ser His Val Gln Val Pro Phe Gln Gln Leu Asn Gln Leu Ala Ala 
        115                 120                 125             


Tyr Pro Tyr Ala Val Trp Tyr Tyr Pro Gln Ile Met Gln Tyr Val Pro 
    130                 135                 140                 


Phe Pro Pro Phe Ser Asp Ile Ser Asn Pro Thr Ala His Glu Asn Tyr 
145                 150                 155                 160 


Glu Lys Asn Asn Val Met Leu Gln Trp 
                165                 


<210>  3635
<211>  176
<212>  PRT
<213>  Homo Sapiens

<400>  3635

Met Arg Leu Leu Ile Leu Thr Cys Leu Val Ala Val Ala Leu Ala Arg 
1               5                   10                  15      


Pro Lys Leu Pro Leu Arg Tyr Pro Glu Arg Leu Gln Asn Pro Ser Glu 
            20                  25                  30          


Ser Ser Glu Pro Ile Pro Leu Glu Ser Arg Glu Glu Tyr Met Asn Gly 
        35                  40                  45              


Met Asn Arg Arg Asn Ile Leu Arg Glu Lys Gln Thr Asp Glu Ile Lys 
    50                  55                  60                  


Asp Thr Arg Asn Glu Ser Thr Gln Asn Cys Val Val Ala Glu Pro Glu 
65                  70                  75                  80  


Lys Met Glu Ser Ser Ile Ser Ser Ser Ser Glu Glu Gln Phe Cys Arg 
                85                  90                  95      


Leu Asn Glu Tyr Asn Gln Leu Gln Leu Gln Ala Ala His Ala Gln Glu 
            100                 105                 110         


Gln Ile Arg Arg Met Asn Glu Asn Ser His Val Gln Val Pro Phe Gln 
        115                 120                 125             


Gln Leu Asn Gln Leu Ala Ala Tyr Pro Tyr Ala Val Trp Tyr Tyr Pro 
    130                 135                 140                 


Gln Ile Met Gln Tyr Val Pro Phe Pro Pro Phe Ser Asp Ile Ser Asn 
145                 150                 155                 160 


Pro Thr Ala His Glu Asn Tyr Glu Lys Asn Asn Val Met Leu Gln Trp 
                165                 170                 175     


<210>  3636
<211>  55
<212>  PRT
<213>  Homo Sapiens

<400>  3636

Gln Arg Asn Ile Leu Arg Glu Lys Gln Thr Asp Glu Ile Lys Asn Cys 
1               5                   10                  15      


Val Val Ala Glu Pro Glu Lys Met Glu Ser Ser Ile Ser Ser Ser Ser 
            20                  25                  30          


Glu Glu Met Ser Leu Ser Lys Cys Ala Glu Gln Phe Cys Arg Leu Asn 
        35                  40                  45              


Glu Tyr Asn Gln Leu Gln Leu 
    50                  55  


<210>  3637
<211>  226
<212>  PRT
<213>  Homo Sapiens

<400>  3637

Met Lys Val Leu Ile Leu Ala Cys Leu Val Ala Leu Ala Leu Ala Arg 
1               5                   10                  15      


Glu Thr Ile Glu Ser Leu Ser Ser Ser Glu Glu Ser Ile Thr Glu Tyr 
            20                  25                  30          


Lys Gln Lys Val Glu Lys Val Lys His Glu Asp Gln Gln Gln Gly Glu 
        35                  40                  45              


Asp Glu His Gln Asp Lys Ile Tyr Pro Ser Phe Gln Pro Gln Pro Leu 
    50                  55                  60                  


Ile Tyr Pro Phe Val Glu Pro Ile Pro Tyr Gly Phe Leu Pro Gln Asn 
65                  70                  75                  80  


Ile Leu Pro Leu Ala Gln Pro Ala Val Val Leu Pro Val Pro Gln Pro 
                85                  90                  95      


Glu Ile Met Glu Val Pro Lys Ala Lys Asp Thr Val Tyr Thr Lys Gly 
            100                 105                 110         


Arg Val Met Pro Val Leu Lys Ser Pro Thr Ile Pro Phe Phe Asp Pro 
        115                 120                 125             


Gln Ile Pro Lys Leu Thr Asp Leu Glu Asn Leu His Leu Pro Leu Pro 
    130                 135                 140                 


Leu Leu Gln Pro Leu Met Gln Gln Val Pro Gln Pro Ile Pro Gln Thr 
145                 150                 155                 160 


Leu Ala Leu Pro Pro Gln Pro Leu Trp Ser Val Pro Gln Pro Lys Val 
                165                 170                 175     


Leu Pro Ile Pro Gln Gln Val Val Pro Tyr Pro Gln Arg Ala Val Pro 
            180                 185                 190         


Val Gln Ala Leu Leu Leu Asn Gln Glu Leu Leu Leu Asn Pro Thr His 
        195                 200                 205             


Gln Ile Tyr Pro Val Thr Gln Pro Leu Ala Pro Val His Asn Pro Ile 
    210                 215                 220                 


Ser Val 
225     


<210>  3638
<211>  182
<212>  PRT
<213>  Homo Sapiens

<400>  3638

Met Lys Ser Phe Leu Leu Val Val Asn Ala Leu Ala Leu Thr Leu Pro 
1               5                   10                  15      


Phe Leu Ala Val Glu Val Gln Asn Gln Lys Gln Pro Ala Cys His Glu 
            20                  25                  30          


Asn Asp Glu Arg Pro Phe Tyr Gln Lys Thr Ala Pro Tyr Val Pro Met 
        35                  40                  45              


Tyr Tyr Val Pro Asn Ser Tyr Pro Tyr Tyr Gly Thr Asn Leu Tyr Gln 
    50                  55                  60                  


Arg Arg Pro Ala Ile Ala Ile Asn Asn Pro Tyr Val Pro Arg Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asn Pro Ala Val Val Arg Pro His Ala Gln Ile Pro Gln Arg 
                85                  90                  95      


Gln Tyr Leu Pro Asn Ser His Pro Pro Thr Val Val Arg Arg Pro Asn 
            100                 105                 110         


Leu His Pro Ser Phe Ile Ala Ile Pro Pro Lys Lys Ile Gln Asp Lys 
        115                 120                 125             


Ile Ile Ile Pro Thr Ile Asn Thr Ile Ala Thr Val Glu Pro Thr Pro 
    130                 135                 140                 


Ala Pro Ala Thr Glu Pro Thr Val Asp Ser Val Val Thr Pro Glu Ala 
145                 150                 155                 160 


Phe Ser Glu Ser Ile Ile Thr Ser Thr Pro Glu Thr Thr Thr Val Ala 
                165                 170                 175     


Val Thr Pro Pro Thr Ala 
            180         


<210>  3639
<211>  141
<212>  PRT
<213>  Homo Sapiens

<400>  3639

Met Ala Gln Tyr Leu Ser Thr Leu Leu Leu Leu Leu Ala Thr Leu Ala 
1               5                   10                  15      


Val Ala Leu Ala Trp Ser Pro Lys Glu Glu Asp Arg Ile Ile Pro Gly 
            20                  25                  30          


Gly Ile Tyr Asn Ala Asp Leu Asn Asp Glu Trp Val Gln Arg Ala Leu 
        35                  40                  45              


His Phe Ala Ile Ser Glu Tyr Asn Lys Ala Thr Lys Asp Asp Tyr Tyr 
    50                  55                  60                  


Arg Arg Pro Leu Arg Val Leu Arg Ala Arg Gln Gln Thr Val Gly Gly 
65                  70                  75                  80  


Val Asn Tyr Phe Phe Asp Val Glu Val Gly Arg Thr Ile Cys Thr Lys 
                85                  90                  95      


Ser Gln Pro Asn Leu Asp Thr Cys Ala Phe His Glu Gln Pro Glu Leu 
            100                 105                 110         


Gln Lys Lys Gln Leu Cys Ser Phe Glu Ile Tyr Glu Val Pro Trp Glu 
        115                 120                 125             


Asn Arg Arg Ser Leu Val Lys Ser Arg Cys Gln Glu Ser 
    130                 135                 140     


<210>  3640
<211>  141
<212>  PRT
<213>  Homo Sapiens

<400>  3640

Met Ala Gln Tyr Leu Ser Thr Leu Leu Leu Leu Leu Ala Thr Leu Ala 
1               5                   10                  15      


Val Ala Leu Ala Trp Ser Pro Lys Glu Glu Asp Arg Ile Ile Pro Gly 
            20                  25                  30          


Gly Ile Tyr Asn Ala Asp Leu Asn Asp Glu Trp Val Gln Arg Ala Leu 
        35                  40                  45              


His Phe Ala Ile Ser Glu Tyr Asn Lys Ala Thr Lys Asp Asp Tyr Tyr 
    50                  55                  60                  


Arg Arg Pro Leu Arg Val Leu Arg Ala Arg Gln Gln Thr Val Gly Gly 
65                  70                  75                  80  


Val Asn Tyr Phe Phe Asp Val Glu Val Gly Arg Thr Ile Cys Thr Lys 
                85                  90                  95      


Ser Gln Pro Asn Leu Asp Thr Cys Ala Phe His Glu Gln Pro Glu Leu 
            100                 105                 110         


Gln Lys Lys Gln Leu Cys Ser Phe Glu Ile Tyr Glu Val Pro Trp Glu 
        115                 120                 125             


Asn Arg Arg Ser Leu Val Lys Ser Arg Cys Gln Glu Ser 
    130                 135                 140     


<210>  3641
<211>  103
<212>  PRT
<213>  Homo Sapiens

<400>  3641

Met Met Ala Glu Pro Trp Gln Ala Leu Gln Leu Leu Leu Ala Ile Leu 
1               5                   10                  15      


Leu Thr Leu Met Ala Leu Pro Tyr Gln Ala Arg Lys Lys Thr Phe Leu 
            20                  25                  30          


Ser Val His Glu Val Met Ala Val Glu Asn Tyr Ala Lys Asp Ser Leu 
        35                  40                  45              


Gln Trp Ile Thr Asp Gln Tyr Asn Lys Glu Ser Asp Asp Lys Tyr His 
    50                  55                  60                  


Phe Arg Ile Phe Arg Val Leu Lys Val Gln Arg Gln Gln Val Asn Cys 
65                  70                  75                  80  


Phe Phe Ser Val Phe Ala Val Pro Trp Phe Glu Gln Tyr Lys Ile Leu 
                85                  90                  95      


Asn Lys Ser Cys Ser Ser Asp 
            100             


<210>  3642
<211>  138
<212>  PRT
<213>  Homo Sapiens

<400>  3642

Met Met Ala Glu Pro Trp Gln Ala Leu Gln Leu Leu Leu Ala Ile Leu 
1               5                   10                  15      


Leu Thr Leu Met Ala Leu Pro Tyr Gln Ala Arg Lys Lys Thr Phe Leu 
            20                  25                  30          


Ser Val His Glu Val Met Ala Val Glu Asn Tyr Ala Lys Asp Ser Leu 
        35                  40                  45              


Gln Trp Ile Thr Asp Gln Tyr Asn Lys Glu Ser Asp Asp Lys Tyr His 
    50                  55                  60                  


Phe Arg Ile Phe Arg Val Leu Lys Val Gln Arg Gln Val Thr Asp His 
65                  70                  75                  80  


Leu Glu Tyr His Leu Asn Val Glu Met Gln Trp Thr Thr Cys Gln Lys 
                85                  90                  95      


Pro Glu Thr Thr Asn Cys Val Pro Gln Glu Arg Glu Leu His Lys Gln 
            100                 105                 110         


Val Asn Cys Phe Phe Ser Val Phe Ala Val Pro Trp Phe Glu Gln Tyr 
        115                 120                 125             


Lys Ile Leu Asn Lys Ser Cys Ser Ser Asp 
    130                 135             


<210>  3643
<211>  141
<212>  PRT
<213>  Homo Sapiens

<400>  3643

Met Ala Trp Pro Leu Cys Thr Leu Leu Leu Leu Leu Ala Thr Gln Ala 
1               5                   10                  15      


Val Ala Leu Ala Trp Ser Pro Gln Glu Glu Asp Arg Ile Ile Glu Gly 
            20                  25                  30          


Gly Ile Tyr Asp Ala Asp Leu Asn Asp Glu Arg Val Gln Arg Ala Leu 
        35                  40                  45              


His Phe Val Ile Ser Glu Tyr Asn Lys Ala Thr Glu Asp Glu Tyr Tyr 
    50                  55                  60                  


Arg Arg Leu Leu Arg Val Leu Arg Ala Arg Glu Gln Ile Val Gly Gly 
65                  70                  75                  80  


Val Asn Tyr Phe Phe Asp Ile Glu Val Gly Arg Thr Ile Cys Thr Lys 
                85                  90                  95      


Ser Gln Pro Asn Leu Asp Thr Cys Ala Phe His Glu Gln Pro Glu Leu 
            100                 105                 110         


Gln Lys Lys Gln Leu Cys Ser Phe Gln Ile Tyr Glu Val Pro Trp Glu 
        115                 120                 125             


Asp Arg Met Ser Leu Val Asn Ser Arg Cys Gln Glu Ala 
    130                 135                 140     


<210>  3644
<211>  146
<212>  PRT
<213>  Homo Sapiens

<400>  3644

Met Ala Gly Pro Leu Arg Ala Pro Leu Leu Leu Leu Ala Ile Leu Ala 
1               5                   10                  15      


Val Ala Leu Ala Val Ser Pro Ala Ala Gly Ser Ser Pro Gly Lys Pro 
            20                  25                  30          


Pro Arg Leu Val Gly Gly Pro Met Asp Ala Ser Val Glu Glu Glu Gly 
        35                  40                  45              


Val Arg Arg Ala Leu Asp Phe Ala Val Gly Glu Tyr Asn Lys Ala Ser 
    50                  55                  60                  


Asn Asp Met Tyr His Ser Arg Ala Leu Gln Val Val Arg Ala Arg Lys 
65                  70                  75                  80  


Gln Ile Val Ala Gly Val Asn Tyr Phe Leu Asp Val Glu Leu Gly Arg 
                85                  90                  95      


Thr Thr Cys Thr Lys Thr Gln Pro Asn Leu Asp Asn Cys Pro Phe His 
            100                 105                 110         


Asp Gln Pro His Leu Lys Arg Lys Ala Phe Cys Ser Phe Gln Ile Tyr 
        115                 120                 125             


Ala Val Pro Trp Gln Gly Thr Met Thr Leu Ser Lys Ser Thr Cys Gln 
    130                 135                 140                 


Asp Ala 
145     


<210>  3645
<211>  146
<212>  PRT
<213>  Homo Sapiens

<400>  3645

Met Ala Gly Pro Leu Arg Ala Pro Leu Leu Leu Leu Ala Ile Leu Ala 
1               5                   10                  15      


Val Ala Leu Ala Val Ser Pro Ala Ala Gly Ser Ser Pro Gly Lys Pro 
            20                  25                  30          


Pro Arg Leu Val Gly Gly Pro Met Asp Ala Ser Val Glu Glu Glu Gly 
        35                  40                  45              


Val Arg Arg Ala Leu Asp Phe Ala Val Gly Glu Tyr Asn Lys Ala Ser 
    50                  55                  60                  


Asn Asp Met Tyr His Ser Arg Ala Leu Gln Val Val Arg Ala Arg Lys 
65                  70                  75                  80  


Gln Ile Val Ala Gly Val Asn Tyr Phe Leu Asp Val Glu Leu Gly Arg 
                85                  90                  95      


Thr Thr Cys Thr Lys Thr Gln Pro Asn Leu Asp Asn Cys Pro Phe His 
            100                 105                 110         


Asp Gln Pro His Leu Lys Arg Lys Ala Phe Cys Ser Phe Gln Ile Tyr 
        115                 120                 125             


Ala Val Pro Trp Gln Gly Thr Met Thr Leu Ser Lys Ser Thr Cys Gln 
    130                 135                 140                 


Asp Ala 
145     


<210>  3646
<211>  146
<212>  PRT
<213>  Homo Sapiens

<400>  3646

Met Ala Gly Pro Leu Arg Ala Pro Leu Leu Leu Leu Ala Ile Leu Ala 
1               5                   10                  15      


Val Ala Leu Ala Val Ser Pro Ala Ala Gly Ser Ser Pro Gly Lys Pro 
            20                  25                  30          


Pro Arg Leu Val Gly Gly Pro Met Asp Ala Ser Val Glu Glu Glu Gly 
        35                  40                  45              


Val Arg Arg Ala Leu Asp Phe Ala Val Gly Glu Tyr Asn Lys Ala Ser 
    50                  55                  60                  


Asn Asp Met Tyr His Ser Arg Ala Leu Gln Val Val Arg Ala Arg Lys 
65                  70                  75                  80  


Gln Ile Val Ala Gly Val Asn Tyr Phe Leu Asp Val Glu Leu Gly Arg 
                85                  90                  95      


Thr Thr Cys Thr Lys Thr Gln Pro Asn Leu Asp Asn Cys Pro Phe His 
            100                 105                 110         


Asp Gln Pro His Leu Lys Arg Lys Ala Phe Cys Ser Phe Gln Ile Tyr 
        115                 120                 125             


Ala Val Pro Trp Gln Gly Thr Met Thr Leu Ser Lys Ser Thr Cys Gln 
    130                 135                 140                 


Asp Ala 
145     


<210>  3647
<211>  141
<212>  PRT
<213>  Homo Sapiens

<400>  3647

Met Ala Arg Pro Leu Cys Thr Leu Leu Leu Leu Met Ala Thr Leu Ala 
1               5                   10                  15      


Gly Ala Leu Ala Ser Ser Ser Lys Glu Glu Asn Arg Ile Ile Pro Gly 
            20                  25                  30          


Gly Ile Tyr Asp Ala Asp Leu Asn Asp Glu Trp Val Gln Arg Ala Leu 
        35                  40                  45              


His Phe Ala Ile Ser Glu Tyr Asn Lys Ala Thr Glu Asp Glu Tyr Tyr 
    50                  55                  60                  


Arg Arg Pro Leu Gln Val Leu Arg Ala Arg Glu Gln Thr Phe Gly Gly 
65                  70                  75                  80  


Val Asn Tyr Phe Phe Asp Val Glu Val Gly Arg Thr Ile Cys Thr Lys 
                85                  90                  95      


Ser Gln Pro Asn Leu Asp Thr Cys Ala Phe His Glu Gln Pro Glu Leu 
            100                 105                 110         


Gln Lys Lys Gln Leu Cys Ser Phe Glu Ile Tyr Glu Val Pro Trp Glu 
        115                 120                 125             


Asp Arg Met Ser Leu Val Asn Ser Arg Cys Gln Glu Ala 
    130                 135                 140     


<210>  3648
<211>  142
<212>  PRT
<213>  Homo Sapiens

<400>  3648

Met Met Trp Pro Met His Thr Pro Leu Leu Leu Leu Thr Ala Leu Met 
1               5                   10                  15      


Val Ala Val Ala Gly Ser Ala Ser Ala Gln Ser Arg Thr Leu Ala Gly 
            20                  25                  30          


Gly Ile His Ala Thr Asp Leu Asn Asp Lys Ser Val Gln Cys Ala Leu 
        35                  40                  45              


Asp Phe Ala Ile Ser Glu Tyr Asn Lys Val Ile Asn Lys Asp Glu Tyr 
    50                  55                  60                  


Tyr Ser Arg Pro Leu Gln Val Met Ala Ala Tyr Gln Gln Ile Val Gly 
65                  70                  75                  80  


Gly Val Asn Tyr Tyr Phe Asn Val Lys Phe Gly Arg Thr Thr Cys Thr 
                85                  90                  95      


Lys Ser Gln Pro Asn Leu Asp Asn Cys Pro Phe Asn Asp Gln Pro Lys 
            100                 105                 110         


Leu Lys Glu Glu Glu Phe Cys Ser Phe Gln Ile Asn Glu Val Pro Trp 
        115                 120                 125             


Glu Asp Lys Ile Ser Ile Leu Asn Tyr Lys Cys Arg Lys Val 
    130                 135                 140         


<210>  3649
<211>  149
<212>  PRT
<213>  Homo Sapiens

<400>  3649

Met Ala Arg Ser Asn Leu Pro Leu Ala Leu Gly Leu Ala Leu Val Ala 
1               5                   10                  15      


Phe Cys Leu Leu Ala Leu Pro Arg Asp Ala Arg Ala Arg Pro Gln Glu 
            20                  25                  30          


Arg Met Val Gly Glu Leu Arg Asp Leu Ser Pro Asp Asp Pro Gln Val 
        35                  40                  45              


Gln Lys Ala Ala Gln Ala Ala Val Ala Ser Tyr Asn Met Gly Ser Asn 
    50                  55                  60                  


Ser Ile Tyr Tyr Phe Arg Asp Thr His Ile Ile Lys Ala Gln Ser Gln 
65                  70                  75                  80  


Leu Val Ala Gly Ile Lys Tyr Phe Leu Thr Met Glu Met Gly Ser Thr 
                85                  90                  95      


Asp Cys Arg Lys Thr Arg Val Thr Gly Asp His Val Asp Leu Thr Thr 
            100                 105                 110         


Cys Pro Leu Ala Ala Gly Ala Gln Gln Glu Lys Leu Arg Cys Asp Phe 
        115                 120                 125             


Glu Val Leu Val Val Pro Trp Gln Asn Ser Ser Gln Leu Leu Lys His 
    130                 135                 140                 


Asn Cys Val Gln Met 
145                 


<210>  3650
<211>  145
<212>  PRT
<213>  Homo Sapiens

<400>  3650

Met Arg Ala Ala Gly Thr Leu Leu Ala Phe Cys Cys Leu Val Leu Ser 
1               5                   10                  15      


Thr Thr Gly Gly Pro Ser Pro Asp Thr Cys Ser Gln Asp Leu Asn Ser 
            20                  25                  30          


Arg Val Lys Pro Gly Phe Pro Lys Thr Ile Lys Thr Asn Asp Pro Gly 
        35                  40                  45              


Val Leu Gln Ala Ala Arg Tyr Ser Val Glu Lys Phe Asn Asn Cys Thr 
    50                  55                  60                  


Asn Asp Met Phe Leu Phe Lys Glu Ser Arg Ile Thr Arg Ala Leu Val 
65                  70                  75                  80  


Gln Ile Val Lys Gly Leu Lys Tyr Met Leu Glu Val Glu Ile Gly Arg 
                85                  90                  95      


Thr Thr Cys Lys Lys Asn Gln His Leu Arg Leu Asp Asp Cys Asp Phe 
            100                 105                 110         


Gln Thr Asn His Thr Leu Lys Gln Thr Leu Ser Cys Tyr Ser Glu Val 
        115                 120                 125             


Trp Val Val Pro Trp Leu Gln His Phe Glu Val Pro Val Leu Arg Cys 
    130                 135                 140                 


His 
145 


<210>  3651
<211>  134
<212>  PRT
<213>  Homo Sapiens

<400>  3651

Met Pro Arg Cys Arg Trp Leu Ser Leu Ile Leu Leu Thr Ile Pro Leu 
1               5                   10                  15      


Ala Leu Val Ala Arg Lys Asp Pro Lys Lys Asn Glu Thr Gly Val Leu 
            20                  25                  30          


Arg Lys Leu Lys Pro Val Asn Ala Ser Asn Ala Asn Val Lys Gln Cys 
        35                  40                  45              


Leu Trp Phe Ala Met Gln Glu Tyr Asn Lys Glu Ser Glu Asp Lys Tyr 
    50                  55                  60                  


Val Phe Leu Val Val Lys Thr Leu Gln Ala Gln Leu Gln Val Thr Asn 
65                  70                  75                  80  


Leu Leu Glu Tyr Leu Ile Asp Val Glu Ile Ala Arg Ser Asp Cys Arg 
                85                  90                  95      


Lys Pro Leu Ser Thr Asn Glu Ile Cys Ala Ile Gln Glu Asn Ser Lys 
            100                 105                 110         


Leu Lys Arg Lys Leu Ser Cys Ser Phe Leu Val Gly Ala Leu Pro Trp 
        115                 120                 125             


Asn Gly Glu Phe Thr Val 
    130                 


<210>  3652
<211>  142
<212>  PRT
<213>  Homo Sapiens

<400>  3652

Met Pro Arg Cys Arg Trp Leu Ser Leu Ile Leu Leu Thr Ile Pro Leu 
1               5                   10                  15      


Ala Leu Val Ala Arg Lys Asp Pro Lys Lys Asn Glu Thr Gly Val Leu 
            20                  25                  30          


Arg Lys Leu Lys Pro Val Asn Ala Ser Asn Ala Asn Val Lys Gln Cys 
        35                  40                  45              


Leu Trp Phe Ala Met Gln Glu Tyr Asn Lys Glu Ser Glu Asp Lys Tyr 
    50                  55                  60                  


Val Phe Leu Val Val Lys Thr Leu Gln Ala Gln Leu Gln Val Thr Asn 
65                  70                  75                  80  


Leu Leu Glu Tyr Leu Ile Asp Val Glu Ile Ala Arg Ser Asp Cys Arg 
                85                  90                  95      


Lys Pro Leu Ser Thr Asn Glu Ile Cys Ala Ile Gln Glu Asn Ser Lys 
            100                 105                 110         


Leu Lys Arg Lys Leu Ser Cys Ser Phe Leu Val Gly Ala Leu Pro Trp 
        115                 120                 125             


Asn Gly Glu Phe Thr Val Met Glu Lys Lys Cys Glu Asp Ala 
    130                 135                 140         


<210>  3653
<211>  159
<212>  PRT
<213>  Homo Sapiens

<400>  3653

Met Ser Ser Pro Gln Arg Arg Lys Ala Met Pro Trp Ala Leu Ser Leu 
1               5                   10                  15      


Leu Leu Met Gly Phe Gln Leu Leu Val Thr Tyr Ala Trp Cys Ser Glu 
            20                  25                  30          


Glu Glu Met Gly Gly Asn Asn Lys Ile Val Gln Asp Pro Met Phe Leu 
        35                  40                  45              


Ala Thr Val Glu Phe Ala Leu Asn Thr Phe Asn Val Gln Ser Lys Glu 
    50                  55                  60                  


Glu His Ala Tyr Arg Leu Leu Arg Val Leu Ser Ser Trp Arg Glu Asp 
65                  70                  75                  80  


Ser Met Asp Arg Lys Trp Arg Gly Lys Met Val Phe Ser Met Asn Leu 
                85                  90                  95      


Gln Leu Arg Gln Thr Val Cys Arg Lys Phe Glu Asp Asp Ile Asp Asn 
            100                 105                 110         


Cys Pro Phe Gln Glu Ser Leu Glu Leu Asn Asn Val Arg Gln Gly Ile 
        115                 120                 125             


Ser Phe Pro Gln Val His Ser Cys Gly Cys Cys Met Gly Cys Gly Val 
    130                 135                 140                 


Gly Thr Gly Ala Ala Asp Lys Ala Ile Pro Arg Asp Lys Gly Lys 
145                 150                 155                 


<210>  3654
<211>  147
<212>  PRT
<213>  Homo Sapiens

<400>  3654

Met Leu Gly Leu Pro Trp Lys Gly Gly Leu Ser Trp Ala Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Gly Ser Gln Ile Leu Leu Ile Tyr Ala Trp His Phe His 
            20                  25                  30          


Glu Gln Arg Asp Cys Asp Glu His Asn Val Met Ala Arg Tyr Leu Pro 
        35                  40                  45              


Ala Thr Val Glu Phe Ala Val His Thr Phe Asn Gln Gln Ser Lys Asp 
    50                  55                  60                  


Tyr Tyr Ala Tyr Arg Leu Gly His Ile Leu Asn Ser Trp Lys Glu Gln 
65                  70                  75                  80  


Val Glu Ser Lys Thr Val Phe Ser Met Glu Leu Leu Leu Gly Arg Thr 
                85                  90                  95      


Arg Cys Gly Lys Phe Glu Asp Asp Ile Asp Asn Cys His Phe Gln Glu 
            100                 105                 110         


Ser Thr Glu Leu Asn Asn Thr Phe Thr Cys Phe Phe Thr Ile Ser Thr 
        115                 120                 125             


Arg Pro Trp Met Thr Gln Phe Ser Leu Leu Asn Lys Thr Cys Leu Glu 
    130                 135                 140                 


Gly Phe His 
145         


<210>  3655
<211>  145
<212>  PRT
<213>  Homo Sapiens

<400>  3655

Met Gly Ile Gly Cys Trp Arg Asn Pro Leu Leu Leu Leu Ile Ala Leu 
1               5                   10                  15      


Val Leu Ser Ala Lys Leu Gly His Phe Gln Arg Trp Glu Gly Phe Gln 
            20                  25                  30          


Gln Lys Leu Met Ser Lys Lys Asn Met Asn Ser Thr Leu Asn Phe Phe 
        35                  40                  45              


Ile Gln Ser Tyr Asn Asn Ala Ser Asn Asp Thr Tyr Leu Tyr Arg Val 
    50                  55                  60                  


Gln Arg Leu Ile Arg Ser Gln Met Gln Leu Thr Thr Gly Val Glu Tyr 
65                  70                  75                  80  


Ile Val Thr Val Lys Ile Gly Trp Thr Lys Cys Lys Arg Asn Asp Thr 
                85                  90                  95      


Ser Asn Ser Ser Cys Pro Leu Gln Ser Lys Lys Leu Arg Lys Ser Leu 
            100                 105                 110         


Ile Cys Glu Ser Leu Ile Tyr Thr Met Pro Trp Ile Asn Tyr Phe Gln 
        115                 120                 125             


Leu Trp Asn Asn Ser Cys Leu Glu Ala Glu His Val Gly Arg Asn Leu 
    130                 135                 140                 


Arg 
145 


<210>  3656
<211>  145
<212>  PRT
<213>  Homo Sapiens

<400>  3656

Met Gly Ile Gly Cys Trp Arg Asn Pro Leu Leu Leu Leu Ile Ala Leu 
1               5                   10                  15      


Val Leu Ser Ala Lys Leu Gly His Phe Gln Arg Trp Glu Gly Phe Gln 
            20                  25                  30          


Gln Lys Leu Met Ser Lys Lys Asn Met Asn Ser Thr Leu Asn Phe Phe 
        35                  40                  45              


Ile Gln Ser Tyr Asn Asn Ala Ser Asn Asp Thr Tyr Leu Tyr Arg Val 
    50                  55                  60                  


Gln Arg Leu Ile Arg Ser Gln Met Gln Leu Thr Thr Gly Val Glu Tyr 
65                  70                  75                  80  


Ile Val Thr Val Lys Ile Gly Trp Thr Lys Cys Lys Arg Asn Asp Thr 
                85                  90                  95      


Ser Asn Ser Ser Cys Pro Leu Gln Ser Lys Lys Leu Arg Lys Ser Leu 
            100                 105                 110         


Ile Cys Glu Ser Leu Ile Tyr Thr Met Pro Trp Ile Asn Tyr Phe Gln 
        115                 120                 125             


Leu Trp Asn Asn Ser Cys Leu Glu Ala Glu His Val Gly Arg Asn Leu 
    130                 135                 140                 


Arg 
145 


<210>  3657
<211>  37
<212>  PRT
<213>  Homo Sapiens

<400>  3657

Met Asn Ser Thr Leu Asn Phe Phe Ile Gln Ser Tyr Asn Asn Ala Ser 
1               5                   10                  15      


Asn Asp Thr Tyr Leu Tyr Arg Val Gln Arg Leu Ile Arg Ser Gln Met 
            20                  25                  30          


Gln Gln Val His Cys 
        35          


<210>  3658
<211>  242
<212>  PRT
<213>  Homo Sapiens

<400>  3658

Met Leu Arg Leu Leu Arg Leu Ala Leu Ala Phe Tyr Gly Arg Thr Ala 
1               5                   10                  15      


Asp Pro Ala Glu Arg Gln Gly Pro Gln Gln Gln Gly Leu Pro Gln Gly 
            20                  25                  30          


Asp Thr Gln Leu Thr Thr Val Gln Gly Val Val Thr Ser Phe Cys Gly 
        35                  40                  45              


Asp Tyr Gly Met Ile Asp Glu Ser Ile Tyr Phe Ser Ser Asp Val Val 
    50                  55                  60                  


Thr Gly Asn Val Pro Leu Lys Val Gly Gln Lys Val Asn Val Val Val 
65                  70                  75                  80  


Glu Glu Asp Lys Pro His Tyr Gly Leu Arg Ala Ile Lys Val Asp Val 
                85                  90                  95      


Val Pro Arg His Leu Tyr Gly Ala Gly Pro Ser Asp Ser Gly Thr Arg 
            100                 105                 110         


Val Leu Ile Gly Cys Val Thr Ser Ile Asn Glu Asp Asn Ile Tyr Ile 
        115                 120                 125             


Ser Asn Ser Ile Tyr Phe Ser Ile Ala Ile Val Ser Glu Asp Phe Val 
    130                 135                 140                 


Pro Tyr Lys Gly Asp Leu Leu Glu Val Glu Tyr Ser Thr Glu Pro Gly 
145                 150                 155                 160 


Ile Ser Asn Ile Lys Ala Thr Ser Val Lys Pro Ile Arg Cys Ile His 
                165                 170                 175     


Thr Glu Glu Val Cys Ile Thr Ser Val His Gly Arg Asn Gly Val Ile 
            180                 185                 190         


Asp Tyr Thr Ile Phe Phe Thr Leu Asp Ser Val Lys Leu Pro Asp Gly 
        195                 200                 205             


Tyr Val Pro Gln Val Asp Asp Ile Val Asn Val Val Met Val Glu Ser 
    210                 215                 220                 


Ile Gln Phe Cys Phe Ile Trp Arg Ala Ile Ser Ile Thr Pro Val His 
225                 230                 235                 240 


Lys Ser 
        


<210>  3659
<211>  264
<212>  PRT
<213>  Homo Sapiens

<400>  3659

Met Leu Arg Leu Leu Arg Leu Ala Leu Ala Phe Tyr Gly Arg Thr Ala 
1               5                   10                  15      


Asp Pro Ala Glu Arg Gln Gly Pro Gln Gln Gln Gly Leu Pro Gln Gly 
            20                  25                  30          


Asp Thr Gln Leu Thr Thr Val Gln Gly Val Val Thr Ser Phe Cys Gly 
        35                  40                  45              


Asp Tyr Gly Met Ile Asp Glu Ser Ile Tyr Phe Ser Ser Asp Val Val 
    50                  55                  60                  


Thr Gly Asn Val Pro Leu Lys Val Gly Gln Lys Val Asn Val Val Val 
65                  70                  75                  80  


Glu Glu Asp Lys Pro His Tyr Gly Leu Arg Ala Ile Lys Val Asp Val 
                85                  90                  95      


Val Pro Arg His Leu Tyr Gly Ala Gly Pro Ser Asp Ser Gly Thr Arg 
            100                 105                 110         


Val Leu Ile Gly Cys Val Thr Ser Ile Asn Glu Asp Asn Ile Tyr Ile 
        115                 120                 125             


Ser Asn Ser Ile Tyr Phe Ser Ile Ala Ile Val Ser Glu Asp Phe Val 
    130                 135                 140                 


Pro Tyr Lys Gly Asp Leu Leu Glu Val Glu Tyr Ser Thr Glu Pro Gly 
145                 150                 155                 160 


Ile Ser Asn Ile Lys Ala Thr Ser Val Lys Pro Ile Arg Cys Ile His 
                165                 170                 175     


Thr Glu Glu Val Cys Ile Thr Ser Val His Gly Arg Asn Gly Val Ile 
            180                 185                 190         


Asp Tyr Thr Ile Phe Phe Thr Leu Asp Ser Val Lys Leu Pro Asp Gly 
        195                 200                 205             


Tyr Val Pro Gln Val Asp Asp Ile Val Asn Val Val Met Val Glu Ser 
    210                 215                 220                 


Ile Gln Phe Cys Phe Ile Trp Arg Ala Ile Ser Ile Thr Pro Val His 
225                 230                 235                 240 


Lys Ser Ser Ser Gly Phe Gln Asp Asp Gly Gly Leu Gly Arg Pro Lys 
                245                 250                 255     


Arg Glu Arg Arg Ser Gln Ser Ile 
            260                 


<210>  3660
<211>  385
<212>  PRT
<213>  Homo Sapiens

<400>  3660

Met Ser Arg Pro Gln Leu Arg Arg Trp Arg Leu Val Ser Ser Pro Pro 
1               5                   10                  15      


Ser Gly Val Pro Gly Leu Ala Leu Leu Ala Leu Leu Ala Leu Leu Ala 
            20                  25                  30          


Leu Arg Leu Ala Ala Gly Thr Asp Cys Pro Cys Pro Glu Pro Glu Leu 
        35                  40                  45              


Cys Arg Pro Ile Arg His His Pro Asp Phe Glu Val Phe Val Phe Asp 
    50                  55                  60                  


Val Gly Gln Lys Thr Trp Lys Ser Tyr Asp Trp Ser Gln Ile Thr Thr 
65                  70                  75                  80  


Val Ala Thr Phe Gly Lys Tyr Asp Ser Glu Leu Met Cys Tyr Ala His 
                85                  90                  95      


Ser Lys Gly Ala Arg Val Val Leu Lys Gly Asp Val Ser Leu Lys Asp 
            100                 105                 110         


Ile Ile Asp Pro Ala Phe Arg Ala Ser Trp Ile Ala Gln Lys Leu Asn 
        115                 120                 125             


Leu Ala Lys Thr Gln Tyr Met Asp Gly Ile Asn Ile Asp Ile Glu Gln 
    130                 135                 140                 


Glu Val Asn Cys Leu Ser Pro Glu Tyr Asp Ala Leu Thr Ala Leu Val 
145                 150                 155                 160 


Lys Glu Thr Thr Asp Ser Phe His Arg Glu Ile Glu Gly Ser Gln Val 
                165                 170                 175     


Thr Phe Asp Val Ala Trp Ser Pro Lys Asn Ile Asp Arg Arg Cys Tyr 
            180                 185                 190         


Asn Tyr Thr Gly Ile Ala Asp Ala Cys Asp Phe Leu Phe Val Met Ser 
        195                 200                 205             


Tyr Asp Glu Gln Ser Gln Ile Trp Ser Glu Cys Ile Ala Ala Ala Asn 
    210                 215                 220                 


Ala Pro Tyr Asn Gln Thr Leu Thr Gly Tyr Asn Asp Tyr Ile Lys Met 
225                 230                 235                 240 


Ser Ile Asn Pro Lys Lys Leu Val Met Gly Val Pro Trp Tyr Gly Tyr 
                245                 250                 255     


Asp Tyr Thr Cys Leu Asn Leu Ser Glu Asp His Val Cys Thr Ile Ala 
            260                 265                 270         


Lys Val Pro Phe Arg Gly Ala Pro Cys Ser Asp Ala Ala Gly Arg Gln 
        275                 280                 285             


Val Pro Tyr Lys Thr Ile Met Lys Gln Ile Asn Ser Ser Ile Ser Gly 
    290                 295                 300                 


Asn Leu Trp Asp Lys Asp Gln Arg Ala Pro Tyr Tyr Asn Tyr Lys Asp 
305                 310                 315                 320 


Pro Ala Gly His Phe His Gln Val Trp Tyr Asp Asn Pro Gln Ser Ile 
                325                 330                 335     


Ser Leu Lys Ala Thr Tyr Ile Gln Asn Tyr Arg Leu Arg Gly Ile Gly 
            340                 345                 350         


Met Trp Asn Ala Asn Cys Leu Asp Tyr Ser Gly Asp Ala Val Ala Lys 
        355                 360                 365             


Gln Gln Thr Glu Glu Met Trp Glu Val Leu Lys Pro Lys Leu Leu Gln 
    370                 375                 380                 


Arg 
385 


<210>  3661
<211>  77
<212>  PRT
<213>  Homo Sapiens

<400>  3661

Met Ser Arg Pro Gln Leu Arg Arg Trp Arg Leu Val Ser Ser Pro Pro 
1               5                   10                  15      


Ser Gly Val Pro Gly Leu Ala Leu Leu Ala Leu Leu Ala Leu Leu Ala 
            20                  25                  30          


Leu Arg Leu Ala Ala Gly Thr Asp Cys Pro Cys Pro Glu Pro Glu Leu 
        35                  40                  45              


Cys Arg Pro Ile Arg His His Pro Asp Phe Glu Val Ser Ala Phe Leu 
    50                  55                  60                  


Cys Ser Ser Arg Ser Gly Leu Gln Gly Thr Lys Arg Ser 
65                  70                  75          


<210>  3662
<211>  77
<212>  PRT
<213>  Homo Sapiens

<400>  3662

Met Ser Arg Pro Gln Leu Arg Arg Trp Arg Leu Val Ser Ser Pro Pro 
1               5                   10                  15      


Ser Gly Val Pro Gly Leu Ala Leu Leu Ala Leu Leu Ala Leu Leu Ala 
            20                  25                  30          


Leu Arg Leu Ala Ala Gly Thr Asp Cys Pro Cys Pro Glu Pro Glu Leu 
        35                  40                  45              


Cys Arg Pro Ile Arg His His Pro Asp Phe Glu Val Ser Ala Phe Leu 
    50                  55                  60                  


Cys Ser Ser Arg Ser Gly Leu Gln Gly Thr Lys Arg Ser 
65                  70                  75          


<210>  3663
<211>  349
<212>  PRT
<213>  Homo Sapiens

<400>  3663

Met Thr Ala Ala Ser Met Gly Pro Val Arg Val Ala Phe Val Val Leu 
1               5                   10                  15      


Leu Ala Leu Cys Ser Arg Pro Ala Val Gly Gln Asn Cys Ser Gly Pro 
            20                  25                  30          


Cys Arg Cys Pro Asp Glu Pro Ala Pro Arg Cys Pro Ala Gly Val Ser 
        35                  40                  45              


Leu Val Leu Asp Gly Cys Gly Cys Cys Arg Val Cys Ala Lys Gln Leu 
    50                  55                  60                  


Gly Glu Leu Cys Thr Glu Arg Asp Pro Cys Asp Pro His Lys Gly Leu 
65                  70                  75                  80  


Phe Cys His Phe Gly Ser Pro Ala Asn Arg Lys Ile Gly Val Cys Thr 
                85                  90                  95      


Ala Lys Asp Gly Ala Pro Cys Ile Phe Gly Gly Thr Val Tyr Arg Ser 
            100                 105                 110         


Gly Glu Ser Phe Gln Ser Ser Cys Lys Tyr Gln Cys Thr Cys Leu Asp 
        115                 120                 125             


Gly Ala Val Gly Cys Met Pro Leu Cys Ser Met Asp Val Arg Leu Pro 
    130                 135                 140                 


Ser Pro Asp Cys Pro Phe Pro Arg Arg Val Lys Leu Pro Gly Lys Cys 
145                 150                 155                 160 


Cys Glu Glu Trp Val Cys Asp Glu Pro Lys Asp Gln Thr Val Val Gly 
                165                 170                 175     


Pro Ala Leu Ala Ala Tyr Arg Leu Glu Asp Thr Phe Gly Pro Asp Pro 
            180                 185                 190         


Thr Met Ile Arg Ala Asn Cys Leu Val Gln Thr Thr Glu Trp Ser Ala 
        195                 200                 205             


Cys Ser Lys Thr Cys Gly Met Gly Ile Ser Thr Arg Val Thr Asn Asp 
    210                 215                 220                 


Asn Ala Ser Cys Arg Leu Glu Lys Gln Ser Arg Leu Cys Met Val Arg 
225                 230                 235                 240 


Pro Cys Glu Ala Asp Leu Glu Glu Asn Ile Lys Lys Gly Lys Lys Cys 
                245                 250                 255     


Ile Arg Thr Pro Lys Ile Ser Lys Pro Ile Lys Phe Glu Leu Ser Gly 
            260                 265                 270         


Cys Thr Ser Met Lys Thr Tyr Arg Ala Lys Phe Cys Gly Val Cys Thr 
        275                 280                 285             


Asp Gly Arg Cys Cys Thr Pro His Arg Thr Thr Thr Leu Pro Val Glu 
    290                 295                 300                 


Phe Lys Cys Pro Asp Gly Glu Val Met Lys Lys Asn Met Met Phe Ile 
305                 310                 315                 320 


Lys Thr Cys Ala Cys His Tyr Asn Cys Pro Gly Asp Asn Asp Ile Phe 
                325                 330                 335     


Glu Ser Leu Tyr Tyr Arg Lys Met Tyr Gly Asp Met Ala 
            340                 345                 


<210>  3664
<211>  243
<212>  PRT
<213>  Homo Sapiens

<400>  3664

Met Arg Pro Gln Gly Pro Ala Ala Ser Pro Gln Arg Leu Arg Gly Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Leu Pro Ala Pro Ser Ser Ala Ser Glu 
            20                  25                  30          


Ile Pro Lys Gly Lys Gln Lys Ala Gln Leu Arg Gln Arg Glu Val Val 
        35                  40                  45              


Asp Leu Tyr Asn Gly Met Cys Leu Gln Gly Pro Ala Gly Val Pro Gly 
    50                  55                  60                  


Arg Asp Gly Ser Pro Gly Ala Asn Gly Ile Pro Gly Thr Pro Gly Ile 
65                  70                  75                  80  


Pro Gly Arg Asp Gly Phe Lys Gly Glu Lys Gly Glu Cys Leu Arg Glu 
                85                  90                  95      


Ser Phe Glu Glu Ser Trp Thr Pro Asn Tyr Lys Gln Cys Ser Trp Ser 
            100                 105                 110         


Ser Leu Asn Tyr Gly Ile Asp Leu Gly Lys Ile Ala Glu Cys Thr Phe 
        115                 120                 125             


Thr Lys Met Arg Ser Asn Ser Ala Leu Arg Val Leu Phe Ser Gly Ser 
    130                 135                 140                 


Leu Arg Leu Lys Cys Arg Asn Ala Cys Cys Gln Arg Trp Tyr Phe Thr 
145                 150                 155                 160 


Phe Asn Gly Ala Glu Cys Ser Gly Pro Leu Pro Ile Glu Ala Ile Ile 
                165                 170                 175     


Tyr Leu Asp Gln Gly Ser Pro Glu Met Asn Ser Thr Ile Asn Ile His 
            180                 185                 190         


Arg Thr Ser Ser Val Glu Gly Leu Cys Glu Gly Ile Gly Ala Gly Leu 
        195                 200                 205             


Val Asp Val Ala Ile Trp Val Gly Thr Cys Ser Asp Tyr Pro Lys Gly 
    210                 215                 220                 


Asp Ala Ser Thr Gly Trp Asn Ser Val Ser Arg Ile Ile Ile Glu Glu 
225                 230                 235                 240 


Leu Pro Lys 
            


<210>  3665
<211>  147
<212>  PRT
<213>  Homo Sapiens

<400>  3665

Met Arg Pro Gln Gly Pro Ala Ala Ser Pro Gln Arg Leu Arg Gly Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Leu Pro Ala Pro Ser Ser Ala Ser Glu 
            20                  25                  30          


Ile Pro Lys Gly Lys Gln Lys Ala Gln Leu Arg Gln Arg Glu Val Val 
        35                  40                  45              


Asp Leu Tyr Asn Gly Met Cys Leu Gln Gly Pro Ala Gly Val Pro Gly 
    50                  55                  60                  


Arg Asp Gly Ser Pro Gly Ala Asn Gly Ile Pro Gly Thr Pro Gly Ile 
65                  70                  75                  80  


Pro Gly Arg Asp Gly Phe Lys Gly Glu Lys Gly Glu Cys Leu Arg Glu 
                85                  90                  95      


Ser Phe Glu Glu Ser Trp Thr Pro Asn Tyr Lys Gln Cys Ser Trp Ser 
            100                 105                 110         


Ser Leu Asn Tyr Gly Ile Asp Leu Gly Lys Ile Ala Val Ser Leu Asn 
        115                 120                 125             


Tyr Phe Lys Ile Glu Ala Arg Phe Lys Gly Phe His Ile Leu Val Leu 
    130                 135                 140                 


Ile Phe Arg 
145         


<210>  3666
<211>  113
<212>  PRT
<213>  Homo Sapiens

<400>  3666

Met Arg Ser Asn Ser Ala Leu Arg Val Leu Phe Ser Gly Ser Leu Arg 
1               5                   10                  15      


Leu Lys Cys Arg Asn Ala Cys Cys Gln Arg Trp Tyr Phe Thr Phe Asn 
            20                  25                  30          


Gly Ala Glu Cys Ser Gly Pro Leu Pro Ile Glu Ala Ile Ile Tyr Leu 
        35                  40                  45              


Asp Gln Gly Ser Pro Glu Met Asn Ser Thr Ile Asn Ile His Arg Thr 
    50                  55                  60                  


Ser Ser Val Glu Gly Leu Cys Glu Gly Ile Gly Ala Gly Leu Val Asp 
65                  70                  75                  80  


Val Ala Ile Trp Val Gly Thr Cys Ser Asp Tyr Pro Lys Gly Asp Ala 
                85                  90                  95      


Ser Thr Gly Trp Asn Ser Val Ser Arg Ile Ile Ile Glu Glu Leu Pro 
            100                 105                 110         


Lys 
    


<210>  3667
<211>  229
<212>  PRT
<213>  Homo Sapiens

<400>  3667

Met Trp Pro Pro Gly Arg Ser Ile Thr Val Lys Leu Arg Glu Lys Thr 
1               5                   10                  15      


Val Ser Arg Lys Leu Glu Met Asn Gly Pro Ser Ala Phe Gln Gly Leu 
            20                  25                  30          


Ile Cys Gly Lys Tyr Asn Gly Met Cys Leu Gln Gly Pro Ala Gly Val 
        35                  40                  45              


Pro Gly Arg Asp Gly Ser Pro Gly Ala Asn Gly Ile Pro Gly Thr Pro 
    50                  55                  60                  


Gly Ile Pro Gly Arg Asp Gly Phe Lys Gly Glu Lys Gly Glu Cys Leu 
65                  70                  75                  80  


Arg Glu Ser Phe Glu Glu Ser Trp Thr Pro Asn Tyr Lys Gln Cys Ser 
                85                  90                  95      


Trp Ser Ser Leu Asn Tyr Gly Ile Asp Leu Gly Lys Ile Ala Glu Cys 
            100                 105                 110         


Thr Phe Thr Lys Met Arg Ser Asn Ser Ala Leu Arg Val Leu Phe Ser 
        115                 120                 125             


Gly Ser Leu Arg Leu Lys Cys Arg Asn Ala Cys Cys Gln Arg Trp Tyr 
    130                 135                 140                 


Phe Thr Phe Asn Gly Ala Glu Cys Ser Gly Pro Leu Pro Ile Glu Ala 
145                 150                 155                 160 


Ile Ile Tyr Leu Asp Gln Gly Ser Pro Glu Met Asn Ser Thr Ile Asn 
                165                 170                 175     


Ile His Arg Thr Ser Ser Val Glu Gly Leu Cys Glu Gly Ile Gly Ala 
            180                 185                 190         


Gly Leu Val Asp Val Ala Ile Trp Val Gly Thr Cys Ser Asp Tyr Pro 
        195                 200                 205             


Lys Gly Asp Ala Ser Thr Gly Trp Asn Ser Val Ser Arg Ile Ile Ile 
    210                 215                 220                 


Glu Glu Leu Pro Lys 
225                 


<210>  3668
<211>  174
<212>  PRT
<213>  Homo Sapiens

<400>  3668

Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
    50                  55                  60                  


Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
65                  70                  75                  80  


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
                85                  90                  95      


Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Ala Lys Glu Lys Lys Pro Ser Tyr 
145                 150                 155                 160 


Asn Arg Gly Leu Cys Glu Asn Ala Pro Asn Arg Ala Arg Met 
                165                 170                 


<210>  3669
<211>  223
<212>  PRT
<213>  Homo Sapiens

<400>  3669

Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
    50                  55                  60                  


Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
65                  70                  75                  80  


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
                85                  90                  95      


Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
145                 150                 155                 160 


Asp Phe Leu Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe 
                165                 170                 175     


Tyr Ser Phe Leu Leu Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys 
            180                 185                 190         


Arg Ser Pro Leu Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu 
        195                 200                 205             


Pro Glu Cys Glu Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
    210                 215                 220             


<210>  3670
<211>  79
<212>  PRT
<213>  Homo Sapiens

<400>  3670

Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Ser Lys Glu Lys Lys Pro Ser 
    50                  55                  60                  


Tyr Asn Arg Gly Leu Cys Glu Asn Ala Pro Asn Arg Ala Arg Met 
65                  70                  75                  


<210>  3671
<211>  137
<212>  PRT
<213>  Homo Sapiens

<400>  3671

Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile 
1               5                   10                  15      


Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val 
            20                  25                  30          


Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys 
        35                  40                  45              


Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser 
    50                  55                  60                  


Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln 
65                  70                  75                  80  


Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu 
                85                  90                  95      


Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr Gln Ile 
            100                 105                 110         


Tyr Val Ile Ala Lys Glu Lys Lys Pro Ser Tyr Asn Arg Gly Leu Cys 
        115                 120                 125             


Glu Asn Ala Pro Asn Arg Ala Arg Met 
    130                 135         


<210>  3672
<211>  53
<212>  PRT
<213>  Homo Sapiens

<400>  3672

Met Ile Arg Asn Trp Leu Thr Ile Phe Ile Leu Phe Pro Leu Lys Leu 
1               5                   10                  15      


Val Glu Lys Cys Glu Ser Ser Val Ser Leu Thr Val Pro Pro Val Val 
            20                  25                  30          


Lys Leu Glu Asn Gly Ser Ser Thr Asn Val Ser Leu Thr Leu Arg Leu 
        35                  40                  45              


Trp Cys Leu Leu Glu 
    50              


<210>  3673
<211>  75
<212>  PRT
<213>  Homo Sapiens

<400>  3673

Met Ile Arg Asn Trp Leu Thr Ile Phe Ile Leu Phe Pro Leu Lys Leu 
1               5                   10                  15      


Val Glu Lys Cys Glu Ser Ser Val Ser Leu Thr Val Pro Pro Val Val 
            20                  25                  30          


Lys Leu Glu Asn Gly Ser Ser Thr Asn Val Ser Leu Thr Leu Arg Pro 
        35                  40                  45              


Pro Leu Asn Ala Thr Leu Val Ile Thr Phe Glu Ile Thr Phe Arg Ser 
    50                  55                  60                  


Lys Asn Ile Thr Ile Leu Glu Leu Pro Asp Glu 
65                  70                  75  


<210>  3674
<211>  122
<212>  PRT
<213>  Homo Sapiens

<400>  3674

Met Ile Arg Asn Trp Leu Thr Ile Phe Ile Leu Phe Pro Leu Lys Leu 
1               5                   10                  15      


Val Glu Lys Cys Glu Ser Ser Val Ser Leu Thr Val Pro Pro Val Val 
            20                  25                  30          


Lys Leu Glu Asn Gly Ser Ser Thr Asn Val Ser Leu Thr Leu Arg Pro 
        35                  40                  45              


Pro Leu Asn Ala Thr Leu Val Ile Thr Phe Glu Ile Thr Phe Arg Ser 
    50                  55                  60                  


Lys Asn Ile Thr Ile Leu Glu Leu Pro Asp Glu Leu Val Glu Ala Gly 
65                  70                  75                  80  


Gly Glu Glu Cys Arg Asp Glu Ile Ser Ser His Glu Ala His Gln Asp 
                85                  90                  95      


Gly Leu Gln Ile Ser Ser Glu Pro Pro Arg Lys Gln Thr Gly Val Lys 
            100                 105                 110         


His Asp Gln Ser Pro Ala Cys Gly Asn Leu 
        115                 120         


<210>  3675
<211>  163
<212>  PRT
<213>  Homo Sapiens

<400>  3675

Met Ile Arg Asn Trp Leu Thr Ile Phe Ile Leu Phe Pro Leu Lys Leu 
1               5                   10                  15      


Val Glu Lys Cys Glu Ser Ser Val Ser Leu Thr Val Pro Pro Val Val 
            20                  25                  30          


Lys Leu Glu Asn Gly Ser Ser Thr Asn Val Ser Leu Thr Leu Arg Pro 
        35                  40                  45              


Pro Leu Asn Ala Thr Leu Val Ile Thr Phe Glu Ile Thr Phe Arg Ser 
    50                  55                  60                  


Lys Asn Ile Thr Ile Leu Glu Leu Pro Asp Glu Val Val Val Pro Pro 
65                  70                  75                  80  


Gly Val Thr Asn Ser Ser Phe Gln Val Thr Ser Gln Asn Val Gly Gln 
                85                  90                  95      


Leu Thr Val Tyr Leu His Gly Asn His Ser Asn Gln Thr Gly Pro Arg 
            100                 105                 110         


Ile Arg Phe Leu Val Ile Arg Ser Ser Ala Ile Ser Ile Ile Asn Gln 
        115                 120                 125             


Val Ile Gly Trp Ile Tyr Phe Val Ala Trp Ser Ile Ser Phe Tyr Pro 
    130                 135                 140                 


Gln Val Ile Met Asn Trp Arg Arg Lys Ser Val Ile Gly Leu Ser Phe 
145                 150                 155                 160 


Asp Phe Val 
            


<210>  3676
<211>  367
<212>  PRT
<213>  Homo Sapiens

<400>  3676

Met Ile Arg Asn Trp Leu Thr Ile Phe Ile Leu Phe Pro Leu Lys Leu 
1               5                   10                  15      


Val Glu Lys Cys Glu Ser Ser Val Ser Leu Thr Val Pro Pro Val Val 
            20                  25                  30          


Lys Leu Glu Asn Gly Ser Ser Thr Asn Val Ser Leu Thr Leu Arg Pro 
        35                  40                  45              


Pro Leu Asn Ala Thr Leu Val Ile Thr Phe Glu Ile Thr Phe Arg Ser 
    50                  55                  60                  


Lys Asn Ile Thr Ile Leu Glu Leu Pro Asp Glu Val Val Val Pro Pro 
65                  70                  75                  80  


Gly Val Thr Asn Ser Ser Phe Gln Val Thr Ser Gln Asn Val Gly Gln 
                85                  90                  95      


Leu Thr Val Tyr Leu His Gly Asn His Ser Asn Gln Thr Gly Pro Arg 
            100                 105                 110         


Ile Arg Phe Leu Val Ile Arg Ser Ser Ala Ile Ser Ile Ile Asn Gln 
        115                 120                 125             


Val Ile Gly Trp Ile Tyr Phe Val Ala Trp Ser Ile Ser Phe Tyr Pro 
    130                 135                 140                 


Gln Val Ile Met Asn Trp Arg Arg Lys Ser Val Ile Gly Leu Ser Phe 
145                 150                 155                 160 


Asp Phe Val Ala Leu Asn Leu Thr Gly Phe Val Ala Tyr Ser Val Phe 
                165                 170                 175     


Asn Ile Gly Leu Leu Trp Val Pro Tyr Ile Lys Glu Gln Phe Leu Leu 
            180                 185                 190         


Lys Tyr Pro Asn Gly Val Asn Pro Val Asn Ser Asn Asp Val Phe Phe 
        195                 200                 205             


Ser Leu His Ala Val Val Leu Thr Leu Ile Ile Ile Val Gln Cys Cys 
    210                 215                 220                 


Leu Tyr Glu Arg Gly Gly Gln Arg Val Ser Trp Pro Ala Ile Gly Phe 
225                 230                 235                 240 


Leu Val Leu Ala Trp Leu Phe Ala Phe Val Thr Met Ile Val Ala Ala 
                245                 250                 255     


Val Gly Val Thr Thr Trp Leu Gln Phe Leu Phe Cys Phe Ser Tyr Ile 
            260                 265                 270         


Lys Leu Ala Val Thr Leu Val Lys Tyr Phe Pro Gln Ala Tyr Met Asn 
        275                 280                 285             


Phe Tyr Tyr Lys Ser Thr Glu Gly Trp Ser Ile Gly Asn Val Leu Leu 
    290                 295                 300                 


Asp Phe Thr Gly Gly Ser Phe Ser Leu Leu Gln Met Phe Leu Gln Ser 
305                 310                 315                 320 


Tyr Asn Asn Asp Gln Trp Thr Leu Ile Phe Gly Asp Pro Thr Lys Phe 
                325                 330                 335     


Gly Leu Gly Val Phe Ser Ile Val Phe Asp Val Val Phe Phe Ile Gln 
            340                 345                 350         


His Phe Cys Leu Tyr Arg Lys Arg Pro Gly Tyr Asp Gln Leu Asn 
        355                 360                 365         


<210>  3677
<211>  400
<212>  PRT
<213>  Homo Sapiens

<400>  3677

Met Ile Arg Asn Trp Leu Thr Ile Phe Ile Leu Phe Pro Leu Lys Leu 
1               5                   10                  15      


Val Glu Lys Cys Glu Ser Ser Val Ser Leu Thr Val Pro Pro Val Val 
            20                  25                  30          


Lys Leu Glu Asn Gly Ser Ser Thr Asn Val Ser Leu Thr Leu Arg Pro 
        35                  40                  45              


Pro Leu Asn Ala Thr Leu Val Ile Thr Phe Glu Ile Thr Phe Arg Ser 
    50                  55                  60                  


Lys Asn Ile Thr Ile Leu Glu Leu Pro Asp Glu Val Val Val Pro Pro 
65                  70                  75                  80  


Gly Val Thr Asn Ser Ser Phe Gln Val Thr Ser Gln Asn Val Gly Gln 
                85                  90                  95      


Leu Thr Val Tyr Leu His Gly Asn His Ser Asn Gln Thr Gly Pro Arg 
            100                 105                 110         


Ile Arg Phe Leu Val Ile Arg Ser Ser Ala Ile Ser Ile Ile Asn Gln 
        115                 120                 125             


Val Ile Gly Trp Ile Tyr Phe Val Ala Trp Ser Ile Ser Phe Tyr Pro 
    130                 135                 140                 


Gln Val Ile Met Asn Trp Arg Arg Lys Ser Val Ile Gly Leu Ser Phe 
145                 150                 155                 160 


Asp Phe Val Ala Leu Asn Leu Thr Gly Phe Val Ala Tyr Ser Val Phe 
                165                 170                 175     


Asn Ile Gly Leu Leu Trp Val Pro Tyr Ile Lys Glu Gln Phe Leu Leu 
            180                 185                 190         


Lys Tyr Pro Asn Gly Val Asn Pro Val Asn Ser Asn Asp Val Phe Phe 
        195                 200                 205             


Ser Leu His Ala Val Val Leu Thr Leu Ile Ile Ile Val Gln Cys Cys 
    210                 215                 220                 


Leu Tyr Glu Arg Gly Gly Gln Arg Val Ser Trp Pro Ala Ile Gly Phe 
225                 230                 235                 240 


Leu Val Leu Ala Trp Leu Phe Ala Phe Val Thr Met Ile Val Ala Ala 
                245                 250                 255     


Val Gly Val Thr Thr Trp Leu Gln Phe Leu Phe Cys Phe Ser Tyr Ile 
            260                 265                 270         


Lys Leu Ala Val Thr Leu Val Lys Tyr Phe Pro Gln Ala Tyr Met Asn 
        275                 280                 285             


Phe Tyr Tyr Lys Ser Thr Glu Gly Trp Ser Ile Gly Asn Val Leu Leu 
    290                 295                 300                 


Asp Phe Thr Gly Gly Ser Phe Ser Leu Leu Gln Met Phe Leu Gln Ser 
305                 310                 315                 320 


Tyr Asn Asn Asp Gln Trp Thr Leu Ile Phe Gly Asp Pro Thr Lys Phe 
                325                 330                 335     


Gly Leu Gly Val Phe Ser Ile Val Phe Asp Val Val Phe Phe Ile Gln 
            340                 345                 350         


His Phe Cys Leu Tyr Arg Lys Arg Pro Gly Leu Gln Ala Ala Arg Thr 
        355                 360                 365             


Gly Ser Gly Ser Arg Leu Arg Gln Asp Trp Ala Pro Ser Leu Gln Pro 
    370                 375                 380                 


Lys Ala Leu Pro Gln Thr Thr Ser Val Ser Ala Ser Ser Leu Lys Gly 
385                 390                 395                 400 


<210>  3678
<211>  20
<212>  PRT
<213>  Homo Sapiens

<400>  3678

Met Asn Trp Arg Arg Lys Ser Val Ile Gly Leu Ser Phe Asp Phe Val 
1               5                   10                  15      


Ala Leu Asn Leu 
            20  


<210>  3679
<211>  28
<212>  PRT
<213>  Homo Sapiens

<400>  3679

Met Asn Trp Arg Arg Lys Ser Val Ile Gly Leu Ser Phe Asp Phe Val 
1               5                   10                  15      


Ala Leu Asn Leu Thr Gly Phe Val Ala Tyr Ser Val 
            20                  25              


<210>  3680
<211>  263
<212>  PRT
<213>  Homo Sapiens

<400>  3680

Met Ala Ser Leu Trp Leu Leu Ser Cys Phe Ser Leu Val Gly Ala Ala 
1               5                   10                  15      


Phe Gly Cys Gly Val Pro Ala Ile His Pro Val Leu Ser Gly Leu Ser 
            20                  25                  30          


Arg Ile Val Asn Gly Glu Asp Ala Val Pro Gly Ser Trp Pro Trp Gln 
        35                  40                  45              


Val Ser Leu Gln Asp Lys Thr Gly Phe His Phe Cys Gly Gly Ser Leu 
    50                  55                  60                  


Ile Ser Glu Asp Trp Val Val Thr Ala Ala His Cys Gly Val Arg Thr 
65                  70                  75                  80  


Ser Asp Val Val Val Ala Gly Glu Phe Asp Gln Gly Ser Asp Glu Glu 
                85                  90                  95      


Asn Ile Gln Val Leu Lys Ile Ala Lys Val Phe Lys Asn Pro Lys Phe 
            100                 105                 110         


Ser Ile Leu Thr Val Asn Asn Asp Ile Thr Leu Leu Lys Leu Ala Thr 
        115                 120                 125             


Pro Ala Arg Phe Ser Gln Thr Val Ser Ala Val Cys Leu Pro Ser Ala 
    130                 135                 140                 


Asp Asp Asp Phe Pro Ala Gly Thr Leu Cys Ala Thr Thr Gly Trp Gly 
145                 150                 155                 160 


Lys Thr Lys Tyr Asn Ala Asn Lys Thr Pro Asp Lys Leu Gln Gln Ala 
                165                 170                 175     


Ala Leu Pro Leu Leu Ser Asn Ala Glu Cys Lys Lys Ser Trp Gly Arg 
            180                 185                 190         


Arg Ile Thr Asp Val Met Ile Cys Ala Gly Ala Ser Gly Val Ser Ser 
        195                 200                 205             


Cys Met Gly Asp Ser Gly Gly Pro Leu Val Cys Gln Lys Asp Gly Ala 
    210                 215                 220                 


Trp Thr Leu Val Gly Ile Val Ser Trp Gly Ser Asp Thr Cys Ser Thr 
225                 230                 235                 240 


Ser Ser Pro Gly Val Tyr Ala Arg Val Thr Lys Leu Ile Pro Trp Val 
                245                 250                 255     


Gln Lys Ile Leu Ala Ala Asn 
            260             


<210>  3681
<211>  182
<212>  PRT
<213>  Homo Sapiens

<400>  3681

Met Cys Gln Gly Gly Pro Glu Leu Ala Ser Val Asp Trp Gly Arg Thr 
1               5                   10                  15      


Gly Arg Ala Ala Arg Arg Gln Val Arg Pro Arg Trp Val Trp Gly Leu 
            20                  25                  30          


Ser Pro Tyr Ser Pro His Ser Pro Pro Gly Cys Gly Val Pro Ala Ile 
        35                  40                  45              


His Pro Val Leu Ser Gly Leu Ser Arg Ile Val Asn Gly Glu Asp Ala 
    50                  55                  60                  


Val Pro Gly Ser Trp Pro Trp Gln Val Ser Leu Gln Asp Lys Thr Gly 
65                  70                  75                  80  


Phe His Phe Cys Gly Gly Ser Leu Ile Ser Glu Asp Trp Val Val Thr 
                85                  90                  95      


Ala Ala His Cys Gly Val Arg Thr Ser Asp Val Val Val Ala Gly Glu 
            100                 105                 110         


Phe Asp Gln Gly Ser Asp Glu Glu Asn Ile Gln Val Leu Lys Ile Ala 
        115                 120                 125             


Lys Val Phe Lys Asn Pro Lys Phe Ser Ile Leu Thr Val Asn Asn Asp 
    130                 135                 140                 


Ile Thr Leu Leu Lys Leu Ala Thr Pro Ala Arg Phe Ser Gln Thr Val 
145                 150                 155                 160 


Ser Ala Val Cys Leu Pro Ser Ala Asp Asp Asp Phe Pro Ala Gly Thr 
                165                 170                 175     


Leu Cys Ala Thr Thr Gly 
            180         


<210>  3682
<211>  16
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3682

Xaa Val Thr Lys Leu Ile Pro Trp Val Gln Lys Ile Leu Ala Ala Asn 
1               5                   10                  15      


<210>  3683
<211>  114
<212>  PRT
<213>  Homo Sapiens

<400>  3683

Asp Lys Thr Gly Phe His Phe Cys Gly Gly Ser Leu Ile Ser Glu Asp 
1               5                   10                  15      


Trp Val Val Thr Ala Ala His Cys Gly Val Arg Thr Ser Asp Val Val 
            20                  25                  30          


Val Ala Gly Glu Phe Asp Gln Gly Ser Asp Glu Glu Asn Ile Gln Val 
        35                  40                  45              


Leu Lys Ile Ala Lys Val Phe Lys Asn Pro Lys Phe Ser Ile Leu Thr 
    50                  55                  60                  


Val Asn Asn Asp Ile Thr Leu Leu Lys Leu Ala Thr Pro Ala Arg Phe 
65                  70                  75                  80  


Ser Gln Thr Val Ser Ala Val Cys Leu Pro Ser Ala Asp Asp Asp Phe 
                85                  90                  95      


Pro Ala Gly Thr Leu Cys Ala Thr Thr Gly Trp Gly Lys Thr Lys Tyr 
            100                 105                 110         


Asn Gly 
        


<210>  3684
<211>  168
<212>  PRT
<213>  Homo Sapiens

<400>  3684

Glu Phe Asp Gln Gly Ser Asp Glu Glu Asn Ile Gln Val Leu Lys Ile 
1               5                   10                  15      


Ala Lys Val Phe Lys Asn Pro Lys Phe Ser Ile Leu Thr Val Asn Asn 
            20                  25                  30          


Asp Ile Thr Leu Leu Lys Leu Ala Thr Pro Ala Arg Phe Ser Gln Thr 
        35                  40                  45              


Val Ser Ala Val Cys Leu Pro Ser Ala Asp Asp Asp Phe Pro Ala Gly 
    50                  55                  60                  


Thr Leu Cys Ala Thr Thr Gly Trp Gly Lys Thr Lys Tyr Asn Ala Asn 
65                  70                  75                  80  


Lys Thr Pro Asp Lys Leu Gln Gln Ala Ala Leu Pro Leu Leu Ser Asn 
                85                  90                  95      


Ala Glu Cys Lys Lys Ser Trp Gly Arg Arg Ile Thr Asp Val Met Ile 
            100                 105                 110         


Cys Ala Gly Gly Asp Ser Gly Gly Pro Leu Val Cys Gln Lys Asp Gly 
        115                 120                 125             


Ala Trp Thr Leu Val Gly Ile Val Ser Trp Gly Ser Arg Thr Cys Ser 
    130                 135                 140                 


Thr Thr Thr Pro Ala Val Tyr Ala Arg Val Ala Lys Leu Ile Pro Trp 
145                 150                 155                 160 


Val Gln Lys Ile Leu Ala Ala Asn 
                165             


<210>  3685
<211>  263
<212>  PRT
<213>  Homo Sapiens

<400>  3685

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly Cys Gly Val Pro Ala Ile His Pro Val Leu Ser Gly Leu Ser 
            20                  25                  30          


Arg Ile Val Asn Gly Glu Asp Ala Val Pro Gly Ser Trp Pro Trp Gln 
        35                  40                  45              


Val Ser Leu Gln Asp Lys Thr Gly Phe His Phe Cys Gly Gly Ser Leu 
    50                  55                  60                  


Ile Ser Glu Asp Trp Val Val Thr Ala Ala His Cys Gly Val Arg Thr 
65                  70                  75                  80  


Ser Asp Val Val Val Ala Gly Glu Phe Asp Gln Gly Ser Asp Glu Glu 
                85                  90                  95      


Asn Ile Gln Val Leu Lys Ile Ala Lys Val Phe Lys Asn Pro Lys Phe 
            100                 105                 110         


Ser Ile Leu Thr Val Asn Asn Asp Ile Thr Leu Leu Lys Leu Ala Thr 
        115                 120                 125             


Pro Ala Arg Phe Ser Gln Thr Val Ser Ala Val Cys Leu Pro Ser Ala 
    130                 135                 140                 


Asp Asp Asp Phe Pro Ala Gly Thr Leu Cys Ala Thr Thr Gly Trp Gly 
145                 150                 155                 160 


Lys Thr Lys Tyr Asn Ala Asn Lys Thr Pro Asp Lys Leu Gln Gln Ala 
                165                 170                 175     


Ala Leu Pro Leu Leu Ser Asn Ala Glu Cys Lys Lys Ser Trp Gly Arg 
            180                 185                 190         


Arg Ile Thr Asp Val Met Ile Cys Ala Gly Ala Ser Gly Val Ser Ser 
        195                 200                 205             


Cys Met Gly Asp Ser Gly Gly Pro Leu Val Cys Gln Lys Asp Gly Ala 
    210                 215                 220                 


Trp Thr Leu Val Gly Ile Val Ser Trp Gly Ser Arg Thr Cys Ser Thr 
225                 230                 235                 240 


Thr Thr Pro Ala Val Tyr Ala Arg Val Ala Lys Leu Ile Pro Trp Val 
                245                 250                 255     


Gln Lys Ile Leu Ala Ala Asn 
            260             


<210>  3686
<211>  137
<212>  PRT
<213>  Homo Sapiens

<400>  3686

Val Ala Gly Glu Phe Asp Gln Gly Ser Asp Glu Glu Asn Ile Gln Val 
1               5                   10                  15      


Leu Lys Ile Ala Lys Val Phe Lys Asn Pro Lys Phe Ser Ile Leu Thr 
            20                  25                  30          


Val Asn Asn Asp Ile Thr Leu Leu Lys Leu Ala Thr Pro Ala Arg Phe 
        35                  40                  45              


Ser Gln Thr Val Ser Ala Val Cys Leu Pro Ser Ala Asp Asp Asp Phe 
    50                  55                  60                  


Pro Ala Gly Thr Leu Cys Ala Thr Thr Gly Trp Gly Lys Thr Lys Tyr 
65                  70                  75                  80  


Asn Ala Asn Lys Thr Pro Asp Lys Leu Gln Gln Ala Ala Leu Pro Leu 
                85                  90                  95      


Leu Ser Asn Ala Glu Cys Lys Lys Ser Trp Gly Arg Arg Ile Thr Asp 
            100                 105                 110         


Val Met Ile Cys Ala Gly Ala Ser Gly Val Ser Ser Cys Met Val Arg 
        115                 120                 125             


Leu Ala Leu Pro Arg Pro Trp Pro Gly 
    130                 135         


<210>  3687
<211>  268
<212>  PRT
<213>  Homo Sapiens

<400>  3687

Met Leu Gly Ile Thr Val Leu Ala Ala Leu Leu Ala Cys Ala Ser Ser 
1               5                   10                  15      


Cys Gly Val Pro Ser Phe Pro Pro Asn Leu Ser Ala Arg Val Val Gly 
            20                  25                  30          


Gly Glu Asp Ala Arg Pro His Ser Trp Pro Trp Gln Ile Ser Leu Gln 
        35                  40                  45              


Tyr Leu Lys Asn Asp Thr Trp Arg His Thr Cys Gly Gly Thr Leu Ile 
    50                  55                  60                  


Ala Ser Asn Phe Val Leu Thr Ala Ala His Cys Ile Ser Asn Thr Arg 
65                  70                  75                  80  


Thr Tyr Arg Val Ala Val Gly Lys Asn Asn Leu Glu Val Glu Asp Glu 
                85                  90                  95      


Glu Gly Ser Leu Phe Val Gly Val Asp Thr Ile His Val His Lys Arg 
            100                 105                 110         


Trp Asn Ala Leu Leu Leu Arg Asn Asp Ile Ala Leu Ile Lys Leu Ala 
        115                 120                 125             


Glu His Val Glu Leu Ser Asp Thr Ile Gln Val Ala Cys Leu Pro Glu 
    130                 135                 140                 


Lys Asp Ser Leu Leu Pro Lys Asp Tyr Pro Cys Tyr Val Thr Gly Trp 
145                 150                 155                 160 


Gly Arg Leu Trp Thr Asn Gly Pro Ile Ala Asp Lys Leu Gln Gln Gly 
                165                 170                 175     


Leu Gln Pro Val Val Asp His Ala Thr Cys Ser Arg Ile Asp Trp Trp 
            180                 185                 190         


Gly Phe Arg Val Lys Lys Thr Met Val Cys Ala Gly Gly Asp Gly Val 
        195                 200                 205             


Ile Ser Ala Cys Asn Gly Asp Ser Gly Gly Pro Leu Asn Cys Gln Leu 
    210                 215                 220                 


Glu Asn Gly Ser Trp Glu Val Phe Gly Ile Val Ser Phe Gly Ser Arg 
225                 230                 235                 240 


Arg Gly Cys Asn Thr Arg Lys Lys Pro Val Val Tyr Thr Arg Val Ser 
                245                 250                 255     


Ala Tyr Ile Asp Trp Ile Asn Glu Lys Met Gln Leu 
            260                 265             


<210>  3688
<211>  69
<212>  PRT
<213>  Homo Sapiens

<400>  3688

Met Leu Gly Ile Thr Val Leu Ala Ala Leu Leu Ala Cys Ala Thr Pro 
1               5                   10                  15      


Gly Pro Thr Val Trp Pro Trp Glu Arg Thr Thr Trp Arg Trp Lys Thr 
            20                  25                  30          


Lys Lys Asp Pro Cys Leu Trp Val Trp Thr Pro Ser Thr Ser Thr Arg 
        35                  40                  45              


Asp Gly Met Pro Ser Cys Cys Ala Met Ile Leu Pro Ser Ser Ser Leu 
    50                  55                  60                  


Gln Ser Met Trp Ser 
65                  


<210>  3689
<211>  190
<212>  PRT
<213>  Homo Sapiens

<400>  3689

Met Leu Leu Leu Ser Leu Thr Leu Ser Leu Val Leu Leu Gly Ser Ser 
1               5                   10                  15      


Trp Gly Cys Gly Ile Pro Ala Ile Lys Pro Ala Leu Ser Phe Ser Gln 
            20                  25                  30          


Arg Ile Val Asn Gly Glu Asn Ala Val Leu Gly Ser Trp Pro Trp Gln 
        35                  40                  45              


Val Ser Leu Gln Asp Ser Ser Gly Phe His Phe Cys Gly Gly Ser Leu 
    50                  55                  60                  


Ile Ser Gln Ser Trp Val Val Thr Ala Ala His Cys Asn Val Ser Pro 
65                  70                  75                  80  


Gly Arg His Phe Val Val Leu Gly Glu Tyr Asp Arg Ser Ser Asn Ala 
                85                  90                  95      


Glu Pro Leu Gln Val Leu Ser Val Ser Arg Ala Ile Thr His Pro Ser 
            100                 105                 110         


Trp Asn Ser Thr Thr Met Asn Asn Asp Val Thr Leu Leu Lys Leu Ala 
        115                 120                 125             


Ser Pro Ala Gln Tyr Thr Thr Arg Ile Ser Pro Val Cys Leu Ala Ser 
    130                 135                 140                 


Ser Asn Glu Ala Leu Leu Ser Ala Arg Arg Glu Thr His Gly Cys Leu 
145                 150                 155                 160 


Leu Val Leu Ser Pro Gly Ala Pro Lys Thr Ala Met Cys Ala His Leu 
                165                 170                 175     


Leu Cys Ile Leu Glu Leu Ala Ser Ser Ala Pro Gly Ser Thr 
            180                 185                 190 


<210>  3690
<211>  264
<212>  PRT
<213>  Homo Sapiens

<400>  3690

Met Leu Leu Leu Ser Leu Thr Leu Ser Leu Val Leu Leu Gly Ser Ser 
1               5                   10                  15      


Trp Gly Cys Gly Ile Pro Ala Ile Lys Pro Ala Leu Ser Phe Ser Gln 
            20                  25                  30          


Arg Ile Val Asn Gly Glu Asn Ala Val Leu Gly Ser Trp Pro Trp Gln 
        35                  40                  45              


Val Ser Leu Gln Asp Ser Ser Gly Phe His Phe Cys Gly Gly Ser Leu 
    50                  55                  60                  


Ile Ser Gln Ser Trp Val Val Thr Ala Ala His Cys Asn Val Ser Pro 
65                  70                  75                  80  


Gly Arg His Phe Val Val Leu Gly Glu Tyr Asp Arg Ser Ser Asn Ala 
                85                  90                  95      


Glu Pro Leu Gln Val Leu Ser Val Ser Arg Ala Ile Thr His Pro Ser 
            100                 105                 110         


Trp Asn Ser Thr Thr Met Asn Asn Asp Val Thr Leu Leu Lys Leu Ala 
        115                 120                 125             


Ser Pro Ala Gln Tyr Thr Thr Arg Ile Ser Pro Val Cys Leu Ala Ser 
    130                 135                 140                 


Ser Asn Glu Ala Leu Thr Glu Gly Leu Thr Cys Val Thr Thr Gly Trp 
145                 150                 155                 160 


Gly Arg Leu Ser Gly Val Gly Asn Val Thr Pro Ala His Leu Gln Gln 
                165                 170                 175     


Val Ala Leu Pro Leu Val Thr Val Asn Gln Cys Arg Gln Tyr Trp Gly 
            180                 185                 190         


Ser Ser Ile Thr Asp Ser Met Ile Cys Ala Gly Gly Ala Gly Ala Ser 
        195                 200                 205             


Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Gln Lys Gly Asn 
    210                 215                 220                 


Thr Trp Val Leu Ile Gly Ile Val Ser Trp Gly Thr Lys Asn Cys Asn 
225                 230                 235                 240 


Val Arg Ala Pro Ala Val Tyr Thr Arg Val Ser Lys Phe Ser Thr Trp 
                245                 250                 255     


Ile Asn Gln Val Ile Ala Tyr Asn 
            260                 


<210>  3691
<211>  190
<212>  PRT
<213>  Homo Sapiens

<400>  3691

Met Leu Leu Leu Ser Leu Thr Leu Ser Leu Val Leu Leu Gly Ser Ser 
1               5                   10                  15      


Trp Gly Gln Gln Arg Leu Pro Leu Leu Arg Trp Phe Ser His Gln Pro 
            20                  25                  30          


Val Leu Gly Gly His Cys Cys Pro Leu Gln Cys Gln Val Leu Ser Val 
        35                  40                  45              


Ser Arg Val Ser Ala Trp Ala Ala Asp Thr Glu Glu Lys Trp Ala Val 
    50                  55                  60                  


Gln Ala Ile Thr His Pro Ser Trp Asn Ser Thr Thr Met Asn Asn Asp 
65                  70                  75                  80  


Val Thr Leu Leu Lys Leu Ala Ser Pro Ala Gln Tyr Thr Thr Arg Ile 
                85                  90                  95      


Ser Pro Val Cys Leu Ala Ser Ser Asn Glu Ala Leu Thr Glu Gly Leu 
            100                 105                 110         


Thr Cys Val Thr Thr Gly Trp Gly Arg Leu Ser Gly Val Gly Asn Val 
        115                 120                 125             


Thr Pro Ala His Leu Gln Gln Val Ala Leu Pro Leu Val Thr Val Asn 
    130                 135                 140                 


Gln Cys Arg Gln Tyr Trp Gly Ser Ser Ile Thr Asp Ser Met Ile Cys 
145                 150                 155                 160 


Ala Gly Gly Ala Gly Ala Ser Ser Cys Gln Gly Asp Ser Gly Gly Pro 
                165                 170                 175     


Leu Val Cys Gln Lys Gly Asn Thr Trp Val Leu Ile Gly Ile 
            180                 185                 190 


<210>  3692
<211>  110
<212>  PRT
<213>  Homo Sapiens

<400>  3692

Met Ile Arg Ala Ala Pro Pro Pro Leu Phe Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Val Ser Trp Ala Ser Arg Gly Glu Ala Ala Pro Asp Gln 
            20                  25                  30          


Asp Glu Ile Gln Arg Leu Pro Gly Leu Ala Lys Gln Pro Ser Phe Arg 
        35                  40                  45              


Gln Tyr Ser Gly Tyr Leu Lys Gly Ser Gly Ser Lys His Leu His Tyr 
    50                  55                  60                  


Trp Phe Val Glu Ser Gln Lys Asp Pro Glu Asn Ser Pro Val Val Leu 
65                  70                  75                  80  


Trp Leu Asn Gly Gly Pro Gly Cys Ser Ser Leu Asp Gly Leu Leu Thr 
                85                  90                  95      


Glu His Gly Pro Phe Leu Val Gln Pro Asp Gly Val Thr Leu 
            100                 105                 110 


<210>  3693
<211>  480
<212>  PRT
<213>  Homo Sapiens

<400>  3693

Met Ile Arg Ala Ala Pro Pro Pro Leu Phe Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Val Ser Trp Ala Ser Arg Gly Glu Ala Ala Pro Asp Gln 
            20                  25                  30          


Asp Glu Ile Gln Arg Leu Pro Gly Leu Ala Lys Gln Pro Ser Phe Arg 
        35                  40                  45              


Gln Tyr Ser Gly Tyr Leu Lys Gly Ser Gly Ser Lys His Leu His Tyr 
    50                  55                  60                  


Trp Phe Val Glu Ser Gln Lys Asp Pro Glu Asn Ser Pro Val Val Leu 
65                  70                  75                  80  


Trp Leu Asn Gly Gly Pro Gly Cys Ser Ser Leu Asp Gly Leu Leu Thr 
                85                  90                  95      


Glu His Gly Pro Phe Leu Val Gln Pro Asp Gly Val Thr Leu Glu Tyr 
            100                 105                 110         


Asn Pro Tyr Ser Trp Asn Leu Ile Ala Asn Val Leu Tyr Leu Glu Ser 
        115                 120                 125             


Pro Ala Gly Val Gly Phe Ser Tyr Ser Asp Asp Lys Phe Tyr Ala Thr 
    130                 135                 140                 


Asn Asp Thr Glu Val Ala Gln Ser Asn Phe Glu Ala Leu Gln Asp Phe 
145                 150                 155                 160 


Phe Arg Leu Phe Pro Glu Tyr Lys Asn Asn Lys Leu Phe Leu Thr Gly 
                165                 170                 175     


Glu Ser Tyr Ala Gly Ile Tyr Ile Pro Thr Leu Ala Val Leu Val Met 
            180                 185                 190         


Gln Asp Pro Ser Met Asn Leu Gln Gly Leu Ala Val Gly Asn Gly Leu 
        195                 200                 205             


Ser Ser Tyr Glu Gln Asn Asp Asn Ser Leu Val Tyr Phe Ala Tyr Tyr 
    210                 215                 220                 


His Gly Leu Leu Gly Asn Arg Leu Trp Ser Ser Leu Gln Thr His Cys 
225                 230                 235                 240 


Cys Ser Gln Asn Lys Cys Asn Phe Tyr Asp Asn Lys Asp Leu Glu Cys 
                245                 250                 255     


Val Thr Asn Leu Gln Glu Val Ala Arg Ile Val Gly Asn Ser Gly Leu 
            260                 265                 270         


Asn Ile Tyr Asn Leu Tyr Ala Pro Cys Ala Gly Gly Val Pro Ser His 
        275                 280                 285             


Phe Arg Tyr Glu Lys Asp Thr Val Val Val Gln Asp Leu Gly Asn Ile 
    290                 295                 300                 


Phe Thr Arg Leu Pro Leu Lys Arg Met Trp His Gln Ala Leu Leu Arg 
305                 310                 315                 320 


Ser Gly Asp Lys Val Arg Met Asp Pro Pro Cys Thr Asn Thr Thr Ala 
                325                 330                 335     


Ala Ser Thr Tyr Leu Asn Asn Pro Tyr Val Arg Lys Ala Leu Asn Ile 
            340                 345                 350         


Pro Glu Gln Leu Pro Gln Trp Asp Met Cys Asn Phe Leu Val Asn Leu 
        355                 360                 365             


Gln Tyr Arg Arg Leu Tyr Arg Ser Met Asn Ser Gln Tyr Leu Lys Leu 
    370                 375                 380                 


Leu Ser Ser Gln Lys Tyr Gln Ile Leu Leu Tyr Asn Gly Asp Val Asp 
385                 390                 395                 400 


Met Ala Cys Asn Phe Met Gly Asp Glu Trp Phe Val Asp Ser Leu Asn 
                405                 410                 415     


Gln Lys Met Glu Val Gln Arg Arg Pro Trp Leu Val Lys Tyr Gly Asp 
            420                 425                 430         


Ser Gly Glu Gln Ile Ala Gly Phe Val Lys Glu Phe Ser His Ile Ala 
        435                 440                 445             


Phe Leu Thr Ile Lys Gly Ala Gly His Met Val Pro Thr Asp Lys Pro 
    450                 455                 460                 


Leu Ala Ala Phe Thr Met Phe Ser Arg Phe Leu Asn Lys Gln Pro Tyr 
465                 470                 475                 480 


<210>  3694
<211>  480
<212>  PRT
<213>  Homo Sapiens

<400>  3694

Met Ile Arg Ala Ala Pro Pro Pro Leu Phe Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Val Ser Trp Ala Ser Arg Gly Glu Ala Ala Pro Asp Gln 
            20                  25                  30          


Asp Glu Ile Gln Arg Leu Pro Gly Leu Ala Lys Gln Pro Ser Phe Arg 
        35                  40                  45              


Gln Tyr Ser Gly Tyr Leu Lys Gly Ser Gly Ser Lys His Leu His Tyr 
    50                  55                  60                  


Trp Phe Val Glu Ser Gln Lys Asp Pro Glu Asn Ser Pro Val Val Leu 
65                  70                  75                  80  


Trp Leu Asn Gly Gly Pro Gly Cys Ser Ser Leu Asp Gly Leu Leu Thr 
                85                  90                  95      


Glu His Gly Pro Phe Leu Val Gln Pro Asp Gly Val Thr Leu Glu Tyr 
            100                 105                 110         


Asn Pro Tyr Ser Trp Asn Leu Ile Ala Asn Val Leu Tyr Leu Glu Ser 
        115                 120                 125             


Pro Ala Gly Val Gly Phe Ser Tyr Ser Asp Asp Lys Phe Tyr Ala Thr 
    130                 135                 140                 


Asn Asp Thr Glu Val Ala Gln Ser Asn Phe Glu Ala Leu Gln Asp Phe 
145                 150                 155                 160 


Phe Arg Leu Phe Pro Glu Tyr Lys Asn Asn Lys Leu Phe Leu Thr Gly 
                165                 170                 175     


Glu Ser Tyr Ala Gly Ile Tyr Ile Pro Thr Leu Ala Val Leu Val Met 
            180                 185                 190         


Gln Asp Pro Ser Met Asn Leu Gln Gly Leu Ala Val Gly Asn Gly Leu 
        195                 200                 205             


Ser Ser Tyr Glu Gln Asn Asp Asn Ser Leu Val Tyr Phe Ala Tyr Tyr 
    210                 215                 220                 


His Gly Leu Leu Gly Asn Arg Leu Trp Ser Ser Leu Gln Thr His Cys 
225                 230                 235                 240 


Cys Ser Gln Asn Lys Cys Asn Phe Tyr Asp Asn Lys Asp Leu Glu Cys 
                245                 250                 255     


Val Thr Asn Leu Gln Glu Val Ala Arg Ile Val Gly Asn Ser Gly Leu 
            260                 265                 270         


Asn Ile Tyr Asn Leu Tyr Ala Pro Cys Ala Gly Gly Val Pro Ser His 
        275                 280                 285             


Phe Arg Tyr Glu Lys Asp Thr Val Val Val Gln Asp Leu Gly Asn Ile 
    290                 295                 300                 


Phe Thr Arg Leu Pro Leu Lys Arg Met Trp His Gln Ala Leu Leu Arg 
305                 310                 315                 320 


Ser Gly Asp Lys Val Arg Met Asp Pro Pro Cys Thr Asn Thr Thr Ala 
                325                 330                 335     


Ala Ser Thr Tyr Leu Asn Asn Pro Tyr Val Arg Lys Ala Leu Asn Ile 
            340                 345                 350         


Pro Glu Gln Leu Pro Gln Trp Asp Met Cys Asn Phe Leu Val Asn Leu 
        355                 360                 365             


Gln Tyr Arg Arg Leu Tyr Arg Ser Met Asn Ser Gln Tyr Leu Lys Leu 
    370                 375                 380                 


Leu Ser Ser Gln Lys Tyr Gln Ile Leu Leu Tyr Asn Gly Asp Val Asp 
385                 390                 395                 400 


Met Ala Cys Asn Phe Met Gly Asp Glu Trp Phe Val Asp Ser Leu Asn 
                405                 410                 415     


Gln Lys Met Glu Val Gln Arg Arg Pro Trp Leu Val Lys Tyr Gly Asp 
            420                 425                 430         


Ser Gly Glu Gln Ile Ala Gly Phe Val Lys Glu Phe Ser His Ile Ala 
        435                 440                 445             


Phe Leu Thr Ile Lys Gly Ala Gly His Met Val Pro Thr Asp Lys Pro 
    450                 455                 460                 


Leu Ala Ala Phe Thr Met Phe Ser Arg Phe Leu Asn Lys Gln Pro Tyr 
465                 470                 475                 480 


<210>  3695
<211>  480
<212>  PRT
<213>  Homo Sapiens

<400>  3695

Met Ile Arg Ala Ala Pro Pro Pro Leu Phe Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Val Ser Trp Ala Ser Arg Gly Glu Ala Ala Pro Asp Gln 
            20                  25                  30          


Asp Glu Ile Gln Arg Leu Pro Gly Leu Ala Lys Gln Pro Ser Phe Arg 
        35                  40                  45              


Gln Tyr Ser Gly Tyr Leu Lys Gly Ser Gly Ser Lys His Leu His Tyr 
    50                  55                  60                  


Trp Phe Val Glu Ser Gln Lys Asp Pro Glu Asn Ser Pro Val Val Leu 
65                  70                  75                  80  


Trp Leu Asn Gly Gly Pro Gly Cys Ser Ser Leu Asp Gly Leu Leu Thr 
                85                  90                  95      


Glu His Gly Pro Phe Leu Val Gln Pro Asp Gly Val Thr Leu Glu Tyr 
            100                 105                 110         


Asn Pro Tyr Ser Trp Asn Leu Ile Ala Asn Val Leu Tyr Leu Glu Ser 
        115                 120                 125             


Pro Ala Gly Val Gly Phe Ser Tyr Ser Asp Asp Lys Phe Tyr Ala Thr 
    130                 135                 140                 


Asn Asp Thr Glu Val Ala Gln Ser Asn Phe Glu Ala Leu Gln Asp Phe 
145                 150                 155                 160 


Phe Arg Leu Phe Pro Glu Tyr Lys Asn Asn Lys Leu Phe Leu Thr Gly 
                165                 170                 175     


Glu Ser Tyr Ala Gly Ile Tyr Ile Pro Thr Leu Ala Val Leu Val Met 
            180                 185                 190         


Gln Asp Pro Ser Met Asn Leu Gln Gly Leu Ala Val Gly Asn Gly Leu 
        195                 200                 205             


Ser Ser Tyr Glu Gln Asn Asp Asn Ser Leu Val Tyr Phe Ala Tyr Tyr 
    210                 215                 220                 


His Gly Leu Leu Gly Asn Arg Leu Trp Ser Ser Leu Gln Thr His Cys 
225                 230                 235                 240 


Cys Ser Gln Asn Lys Cys Asn Phe Tyr Asp Asn Lys Asp Leu Glu Cys 
                245                 250                 255     


Val Thr Asn Leu Gln Glu Val Ala Arg Ile Val Gly Asn Ser Gly Leu 
            260                 265                 270         


Asn Ile Tyr Asn Leu Tyr Ala Pro Cys Ala Gly Gly Val Pro Ser His 
        275                 280                 285             


Phe Arg Tyr Glu Lys Asp Thr Val Val Val Gln Asp Leu Gly Asn Ile 
    290                 295                 300                 


Phe Thr Arg Leu Pro Leu Lys Arg Met Trp His Gln Ala Leu Leu Arg 
305                 310                 315                 320 


Ser Gly Asp Lys Val Arg Met Asp Pro Pro Cys Thr Asn Thr Thr Ala 
                325                 330                 335     


Ala Ser Thr Tyr Leu Asn Asn Pro Tyr Val Arg Lys Ala Leu Asn Ile 
            340                 345                 350         


Pro Glu Gln Leu Pro Gln Trp Asp Met Cys Asn Phe Leu Val Asn Leu 
        355                 360                 365             


Gln Tyr Arg Arg Leu Tyr Arg Ser Met Asn Ser Gln Tyr Leu Lys Leu 
    370                 375                 380                 


Leu Ser Ser Gln Lys Tyr Gln Ile Leu Leu Tyr Asn Gly Asp Val Asp 
385                 390                 395                 400 


Met Ala Cys Asn Phe Met Gly Asp Glu Trp Phe Val Asp Ser Leu Asn 
                405                 410                 415     


Gln Lys Met Glu Val Gln Arg Arg Pro Trp Leu Val Lys Tyr Gly Asp 
            420                 425                 430         


Ser Gly Glu Gln Ile Ala Gly Phe Val Lys Glu Phe Ser His Ile Ala 
        435                 440                 445             


Phe Leu Thr Ile Lys Gly Ala Gly His Met Val Pro Thr Asp Lys Pro 
    450                 455                 460                 


Leu Ala Ala Phe Thr Met Phe Ser Arg Phe Leu Asn Lys Gln Pro Tyr 
465                 470                 475                 480 


<210>  3696
<211>  82
<212>  PRT
<213>  Homo Sapiens

<400>  3696

Met Thr Ser Ser Pro Arg Ala Pro Pro Gly Glu Gln Gly Arg Gly Gly 
1               5                   10                  15      


Ala Glu Met Ile Arg Ala Ala Pro Pro Pro Leu Phe Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Leu Val Ser Trp Ala Ser Arg Gly Glu Ala Ala Pro 
        35                  40                  45              


Asp Gln Asp Glu Ile Gln Arg Leu Pro Gly Leu Ala Lys Gln Pro Ser 
    50                  55                  60                  


Phe Arg Gln Tyr Ser Gly Tyr Leu Lys Gly Ser Gly Ser Lys His Leu 
65                  70                  75                  80  


His Tyr 
        


<210>  3697
<211>  481
<212>  PRT
<213>  Homo Sapiens

<400>  3697

Met Thr Ser Ser Pro Arg Ala Pro Pro Gly Glu Gln Gly Arg Gly Gly 
1               5                   10                  15      


Ala Glu Met Ile Arg Ala Ala Pro Pro Pro Leu Phe Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Leu Val Ser Trp Ala Ser Arg Gly Glu Ala Ala Pro 
        35                  40                  45              


Asp Gln Asp Glu Ile Gln Arg Leu Pro Gly Leu Ala Lys Gln Pro Ser 
    50                  55                  60                  


Phe Arg Gln Tyr Ser Gly Tyr Leu Lys Gly Ser Gly Ser Lys His Leu 
65                  70                  75                  80  


His Tyr Trp Phe Val Glu Ser Gln Lys Asp Pro Glu Asn Ser Pro Val 
                85                  90                  95      


Val Leu Trp Leu Asn Gly Gly Pro Gly Cys Ser Ser Leu Asp Gly Leu 
            100                 105                 110         


Leu Thr Glu His Gly Pro Phe Leu Ile Ala Asn Val Leu Tyr Leu Glu 
        115                 120                 125             


Ser Pro Ala Gly Val Gly Phe Ser Tyr Ser Asp Asp Lys Phe Tyr Ala 
    130                 135                 140                 


Thr Asn Asp Thr Glu Val Ala Gln Ser Asn Phe Glu Ala Leu Gln Asp 
145                 150                 155                 160 


Phe Phe Arg Leu Phe Pro Glu Tyr Lys Asn Asn Lys Leu Phe Leu Thr 
                165                 170                 175     


Gly Glu Ser Tyr Ala Gly Ile Tyr Ile Pro Thr Leu Ala Val Leu Val 
            180                 185                 190         


Met Gln Asp Pro Ser Met Asn Leu Gln Gly Leu Ala Val Gly Asn Gly 
        195                 200                 205             


Leu Ser Ser Tyr Glu Gln Asn Asp Asn Ser Leu Val Tyr Phe Ala Tyr 
    210                 215                 220                 


Tyr His Gly Leu Leu Gly Asn Arg Leu Trp Ser Ser Leu Gln Thr His 
225                 230                 235                 240 


Cys Cys Ser Gln Asn Lys Cys Asn Phe Tyr Asp Asn Lys Asp Leu Glu 
                245                 250                 255     


Cys Val Thr Asn Leu Gln Glu Val Ala Arg Ile Val Gly Asn Ser Gly 
            260                 265                 270         


Leu Asn Ile Tyr Asn Leu Tyr Ala Pro Cys Ala Gly Gly Val Pro Ser 
        275                 280                 285             


His Phe Arg Tyr Glu Lys Asp Thr Val Val Val Gln Asp Leu Gly Asn 
    290                 295                 300                 


Ile Phe Thr Arg Leu Pro Leu Lys Arg Met Trp His Gln Ala Leu Leu 
305                 310                 315                 320 


Arg Ser Gly Asp Lys Val Arg Met Asp Pro Pro Cys Thr Asn Thr Thr 
                325                 330                 335     


Ala Ala Ser Thr Tyr Leu Asn Asn Pro Tyr Val Arg Lys Ala Leu Asn 
            340                 345                 350         


Ile Pro Glu Gln Leu Pro Gln Trp Asp Met Cys Asn Phe Leu Val Asn 
        355                 360                 365             


Leu Gln Tyr Arg Arg Leu Tyr Arg Ser Met Asn Ser Gln Tyr Leu Lys 
    370                 375                 380                 


Leu Leu Ser Ser Gln Lys Tyr Gln Ile Leu Leu Tyr Asn Gly Asp Val 
385                 390                 395                 400 


Asp Met Ala Cys Asn Phe Met Gly Asp Glu Trp Phe Val Asp Ser Leu 
                405                 410                 415     


Asn Gln Lys Met Glu Val Gln Arg Arg Pro Trp Leu Val Lys Tyr Gly 
            420                 425                 430         


Asp Ser Gly Glu Gln Ile Ala Gly Phe Val Lys Glu Phe Ser His Ile 
        435                 440                 445             


Ala Phe Leu Thr Ile Lys Gly Ala Gly His Met Val Pro Thr Asp Lys 
    450                 455                 460                 


Pro Leu Ala Ala Phe Thr Met Phe Ser Arg Phe Leu Asn Lys Gln Pro 
465                 470                 475                 480 


Tyr 
    


<210>  3698
<211>  498
<212>  PRT
<213>  Homo Sapiens

<400>  3698

Met Thr Ser Ser Pro Arg Ala Pro Pro Gly Glu Gln Gly Arg Gly Gly 
1               5                   10                  15      


Ala Glu Met Ile Arg Ala Ala Pro Pro Pro Leu Phe Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Leu Val Ser Trp Ala Ser Arg Gly Glu Ala Ala Pro 
        35                  40                  45              


Asp Gln Asp Glu Ile Gln Arg Leu Pro Gly Leu Ala Lys Gln Pro Ser 
    50                  55                  60                  


Phe Arg Gln Tyr Ser Gly Tyr Leu Lys Gly Ser Gly Ser Lys His Leu 
65                  70                  75                  80  


His Tyr Trp Phe Val Glu Ser Gln Lys Asp Pro Glu Asn Ser Pro Val 
                85                  90                  95      


Val Leu Trp Leu Asn Gly Gly Pro Gly Cys Ser Ser Leu Asp Gly Leu 
            100                 105                 110         


Leu Thr Glu His Gly Pro Phe Leu Val Gln Pro Asp Gly Val Thr Leu 
        115                 120                 125             


Glu Tyr Asn Pro Tyr Ser Trp Asn Leu Ile Ala Asn Val Leu Tyr Leu 
    130                 135                 140                 


Glu Ser Pro Ala Gly Val Gly Phe Ser Tyr Ser Asp Asp Lys Phe Tyr 
145                 150                 155                 160 


Ala Thr Asn Asp Thr Glu Val Ala Gln Ser Asn Phe Glu Ala Leu Gln 
                165                 170                 175     


Asp Phe Phe Arg Leu Phe Pro Glu Tyr Lys Asn Asn Lys Leu Phe Leu 
            180                 185                 190         


Thr Gly Glu Ser Tyr Ala Gly Ile Tyr Ile Pro Thr Leu Ala Val Leu 
        195                 200                 205             


Val Met Gln Asp Pro Ser Met Asn Leu Gln Gly Leu Ala Val Gly Asn 
    210                 215                 220                 


Gly Leu Ser Ser Tyr Glu Gln Asn Asp Asn Ser Leu Val Tyr Phe Ala 
225                 230                 235                 240 


Tyr Tyr His Gly Leu Leu Gly Asn Arg Leu Trp Ser Ser Leu Gln Thr 
                245                 250                 255     


His Cys Cys Ser Gln Asn Lys Cys Asn Phe Tyr Asp Asn Lys Asp Leu 
            260                 265                 270         


Glu Cys Val Thr Asn Leu Gln Glu Val Ala Arg Ile Val Gly Asn Ser 
        275                 280                 285             


Gly Leu Asn Ile Tyr Asn Leu Tyr Ala Pro Cys Ala Gly Gly Val Pro 
    290                 295                 300                 


Ser His Phe Arg Tyr Glu Lys Asp Thr Val Val Val Gln Asp Leu Gly 
305                 310                 315                 320 


Asn Ile Phe Thr Arg Leu Pro Leu Lys Arg Met Trp His Gln Ala Leu 
                325                 330                 335     


Leu Arg Ser Gly Asp Lys Val Arg Met Asp Pro Pro Cys Thr Asn Thr 
            340                 345                 350         


Thr Ala Ala Ser Thr Tyr Leu Asn Asn Pro Tyr Val Arg Lys Ala Leu 
        355                 360                 365             


Asn Ile Pro Glu Gln Leu Pro Gln Trp Asp Met Cys Asn Phe Leu Val 
    370                 375                 380                 


Asn Leu Gln Tyr Arg Arg Leu Tyr Arg Ser Met Asn Ser Gln Tyr Leu 
385                 390                 395                 400 


Lys Leu Leu Ser Ser Gln Lys Tyr Gln Ile Leu Leu Tyr Asn Gly Asp 
                405                 410                 415     


Val Asp Met Ala Cys Asn Phe Met Gly Asp Glu Trp Phe Val Asp Ser 
            420                 425                 430         


Leu Asn Gln Lys Met Glu Val Gln Arg Arg Pro Trp Leu Val Lys Tyr 
        435                 440                 445             


Gly Asp Ser Gly Glu Gln Ile Ala Gly Phe Val Lys Glu Phe Ser His 
    450                 455                 460                 


Ile Ala Phe Leu Thr Ile Lys Gly Ala Gly His Met Val Pro Thr Asp 
465                 470                 475                 480 


Lys Pro Leu Ala Ala Phe Thr Met Phe Ser Arg Phe Leu Asn Lys Gln 
                485                 490                 495     


Pro Tyr 
        


<210>  3699
<211>  231
<212>  PRT
<213>  Homo Sapiens

<400>  3699

Met Thr Ser Ser Pro Arg Ala Pro Pro Gly Glu Gln Gly Arg Gly Gly 
1               5                   10                  15      


Ala Glu Met Ile Arg Ala Ala Pro Pro Pro Leu Phe Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Leu Val Ser Trp Ala Ser Arg Gly Glu Ala Ala Pro 
        35                  40                  45              


Asp Gln Asp Glu Ile Gln Arg Leu Pro Gly Leu Ala Lys Gln Pro Ser 
    50                  55                  60                  


Phe Arg Gln Tyr Ser Gly Tyr Leu Lys Gly Ser Gly Ser Lys His Leu 
65                  70                  75                  80  


His Tyr Trp Phe Val Glu Ser Gln Lys Asp Pro Glu Asn Ser Pro Val 
                85                  90                  95      


Val Leu Trp Leu Asn Gly Gly Pro Gly Cys Ser Ser Leu Asp Gly Leu 
            100                 105                 110         


Leu Thr Glu His Gly Pro Phe Leu Val Gln Pro Asp Gly Val Thr Leu 
        115                 120                 125             


Glu Tyr Asn Pro Tyr Ser Trp Asn Leu Ile Ala Asn Val Leu Tyr Leu 
    130                 135                 140                 


Glu Ser Pro Ala Gly Val Gly Phe Ser Tyr Ser Asp Asp Lys Phe Tyr 
145                 150                 155                 160 


Ala Thr Asn Asp Thr Glu Val Ala Gln Ser Asn Phe Glu Ala Leu Gln 
                165                 170                 175     


Asp Phe Phe Arg Leu Phe Pro Glu Tyr Lys Asn Asn Lys Leu Phe Leu 
            180                 185                 190         


Thr Gly Glu Ser Tyr Ala Gly Ile Tyr Ile Pro Thr Leu Ala Val Leu 
        195                 200                 205             


Val Met Gln Asp Pro Ser Met Asn Leu Gln Val Gln Gly Ala Gly Cys 
    210                 215                 220                 


Gly Gln Trp Thr Leu Leu Leu 
225                 230     


<210>  3700
<211>  202
<212>  PRT
<213>  Homo Sapiens

<400>  3700

Gln Asp Phe Phe Arg Leu Phe Pro Glu Tyr Lys Asn Asn Lys Leu Phe 
1               5                   10                  15      


Leu Thr Gly Glu Ser Tyr Ala Gly Ile Tyr Ile Pro Thr Leu Ala Val 
            20                  25                  30          


Leu Val Met Gln Asp Pro Ser Met Asn Leu Gln Gly Leu Ala Val Gly 
        35                  40                  45              


Asn Gly Leu Ser Ser Tyr Glu Gln Asn Asp Asn Ser Leu Val Tyr Phe 
    50                  55                  60                  


Ala Tyr Tyr His Gly Leu Leu Gly Asn Arg Leu Trp Ser Ser Leu Gln 
65                  70                  75                  80  


Thr His Cys Cys Ser Gln Asn Lys Cys Asn Phe Tyr Asp Asn Lys Asp 
                85                  90                  95      


Leu Glu Cys Val Thr Asn Leu Gln Glu Val Ala Arg Ile Val Gly Asn 
            100                 105                 110         


Ser Gly Leu Asn Ile Tyr Asn Leu Tyr Ala Pro Cys Ala Gly Gly Val 
        115                 120                 125             


Pro Ser His Phe Arg Thr Leu Leu Trp Ser Arg Ile Trp Ala Thr Ser 
    130                 135                 140                 


Ser Leu Ala Cys His Ser Ser Gly Cys Gly Ile Arg His Cys Cys Ala 
145                 150                 155                 160 


Gln Gly Ile Lys Cys Ala Trp Thr Pro Pro Ala Pro Thr Gln Gln Leu 
                165                 170                 175     


Leu Pro Pro Thr Ser Thr Thr Arg Thr Cys Gly Arg Pro Ser Thr Ser 
            180                 185                 190         


Arg Ser Ser Cys His Asn Gly Thr Cys Ala 
        195                 200         


<210>  3701
<211>  21
<212>  PRT
<213>  Homo Sapiens

<400>  3701

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro 
            20      


<210>  3702
<211>  32
<212>  PRT
<213>  Homo Sapiens

<400>  3702

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


<210>  3703
<211>  55
<212>  PRT
<213>  Homo Sapiens

<400>  3703

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu 
    50                  55  


<210>  3704
<211>  68
<212>  PRT
<213>  Homo Sapiens

<400>  3704

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro 
65              


<210>  3705
<211>  70
<212>  PRT
<213>  Homo Sapiens

<400>  3705

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln 
65                  70  


<210>  3706
<211>  70
<212>  PRT
<213>  Homo Sapiens

<400>  3706

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln 
65                  70  


<210>  3707
<211>  92
<212>  PRT
<213>  Homo Sapiens

<400>  3707

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln 
                85                  90          


<210>  3708
<211>  98
<212>  PRT
<213>  Homo Sapiens

<400>  3708

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile 
                85                  90                  95      


Lys Glu 
        


<210>  3709
<211>  101
<212>  PRT
<213>  Homo Sapiens

<400>  3709

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp 
            100     


<210>  3710
<211>  136
<212>  PRT
<213>  Homo Sapiens

<400>  3710

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
            100                 105                 110         


Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala His 
        115                 120                 125             


Val Ser Val Glu Val Ser Ala Glu 
    130                 135     


<210>  3711
<211>  143
<212>  PRT
<213>  Homo Sapiens

<400>  3711

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
            100                 105                 110         


Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala His 
        115                 120                 125             


Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly 
    130                 135                 140             


<210>  3712
<211>  143
<212>  PRT
<213>  Homo Sapiens

<400>  3712

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
            100                 105                 110         


Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala His 
        115                 120                 125             


Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly 
    130                 135                 140             


<210>  3713
<211>  149
<212>  PRT
<213>  Homo Sapiens

<400>  3713

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
            100                 105                 110         


Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala His 
        115                 120                 125             


Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly Ser 
    130                 135                 140                 


Met Cys Gly Asp Gly 
145                 


<210>  3714
<211>  165
<212>  PRT
<213>  Homo Sapiens

<400>  3714

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
            100                 105                 110         


Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala His 
        115                 120                 125             


Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly Ser 
    130                 135                 140                 


Met Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp Asn 
145                 150                 155                 160 


Phe Trp Thr Arg Lys 
                165 


<210>  3715
<211>  170
<212>  PRT
<213>  Homo Sapiens

<400>  3715

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
            100                 105                 110         


Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala His 
        115                 120                 125             


Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly Ser 
    130                 135                 140                 


Met Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp Asn 
145                 150                 155                 160 


Phe Trp Thr Arg Lys Gly Leu Val Ser Gly 
                165                 170 


<210>  3716
<211>  175
<212>  PRT
<213>  Homo Sapiens

<400>  3716

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
            100                 105                 110         


Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala His 
        115                 120                 125             


Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly Ser 
    130                 135                 140                 


Met Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp Asn 
145                 150                 155                 160 


Phe Trp Thr Arg Lys Gly Leu Val Ser Gly Gly Leu Tyr Glu Ser 
                165                 170                 175 


<210>  3717
<211>  339
<212>  PRT
<213>  Homo Sapiens

<400>  3717

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
            100                 105                 110         


Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala His 
        115                 120                 125             


Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly Ser 
    130                 135                 140                 


Met Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp Asn 
145                 150                 155                 160 


Phe Trp Thr Arg Lys Gly Leu Val Ser Gly Gly Leu Tyr Glu Ser His 
                165                 170                 175     


Val Gly Cys Arg Pro Tyr Ser Ile Pro Pro Cys Glu His His Val Asn 
            180                 185                 190         


Gly Ser Arg Pro Pro Cys Thr Gly Glu Gly Asp Thr Pro Lys Cys Ser 
        195                 200                 205             


Lys Ile Cys Glu Pro Gly Tyr Ser Pro Thr Tyr Lys Gln Asp Lys His 
    210                 215                 220                 


Tyr Gly Tyr Asn Ser Tyr Ser Val Ser Asn Ser Glu Lys Asp Ile Met 
225                 230                 235                 240 


Ala Glu Ile Tyr Lys Asn Gly Pro Val Glu Gly Ala Phe Ser Val Tyr 
                245                 250                 255     


Ser Asp Phe Leu Leu Tyr Lys Ser Gly Val Tyr Gln His Val Thr Gly 
            260                 265                 270         


Glu Met Met Gly Gly His Ala Ile Arg Ile Leu Gly Trp Gly Val Glu 
        275                 280                 285             


Asn Gly Thr Pro Tyr Trp Leu Val Ala Asn Ser Trp Asn Thr Asp Trp 
    290                 295                 300                 


Gly Asp Asn Gly Phe Phe Lys Ile Leu Arg Gly Gln Asp His Cys Gly 
305                 310                 315                 320 


Ile Glu Ser Glu Val Val Ala Gly Ile Pro Arg Thr Asp Gln Tyr Trp 
                325                 330                 335     


Glu Lys Ile 
            


<210>  3718
<211>  339
<212>  PRT
<213>  Homo Sapiens

<400>  3718

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
            100                 105                 110         


Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala His 
        115                 120                 125             


Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly Ser 
    130                 135                 140                 


Met Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp Asn 
145                 150                 155                 160 


Phe Trp Thr Arg Lys Gly Leu Val Ser Gly Gly Leu Tyr Glu Ser His 
                165                 170                 175     


Val Gly Cys Arg Pro Tyr Ser Ile Pro Pro Cys Glu His His Val Asn 
            180                 185                 190         


Gly Ser Arg Pro Pro Cys Thr Gly Glu Gly Asp Thr Pro Lys Cys Ser 
        195                 200                 205             


Lys Ile Cys Glu Pro Gly Tyr Ser Pro Thr Tyr Lys Gln Asp Lys His 
    210                 215                 220                 


Tyr Gly Tyr Asn Ser Tyr Ser Val Ser Asn Ser Glu Lys Asp Ile Met 
225                 230                 235                 240 


Ala Glu Ile Tyr Lys Asn Gly Pro Val Glu Gly Ala Phe Ser Val Tyr 
                245                 250                 255     


Ser Asp Phe Leu Leu Tyr Lys Ser Gly Val Tyr Gln His Val Thr Gly 
            260                 265                 270         


Glu Met Met Gly Gly His Ala Ile Arg Ile Leu Gly Trp Gly Val Glu 
        275                 280                 285             


Asn Gly Thr Pro Tyr Trp Leu Val Ala Asn Ser Trp Asn Thr Asp Trp 
    290                 295                 300                 


Gly Asp Asn Gly Phe Phe Lys Ile Leu Arg Gly Gln Asp His Cys Gly 
305                 310                 315                 320 


Ile Glu Ser Glu Val Val Ala Gly Ile Pro Arg Thr Asp Gln Tyr Trp 
                325                 330                 335     


Glu Lys Ile 
            


<210>  3719
<211>  339
<212>  PRT
<213>  Homo Sapiens

<400>  3719

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
            100                 105                 110         


Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala His 
        115                 120                 125             


Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly Ser 
    130                 135                 140                 


Met Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp Asn 
145                 150                 155                 160 


Phe Trp Thr Arg Lys Gly Leu Val Ser Gly Gly Leu Tyr Glu Ser His 
                165                 170                 175     


Val Gly Cys Arg Pro Tyr Ser Ile Pro Pro Cys Glu His His Val Asn 
            180                 185                 190         


Gly Ser Arg Pro Pro Cys Thr Gly Glu Gly Asp Thr Pro Lys Cys Ser 
        195                 200                 205             


Lys Ile Cys Glu Pro Gly Tyr Ser Pro Thr Tyr Lys Gln Asp Lys His 
    210                 215                 220                 


Tyr Gly Tyr Asn Ser Tyr Ser Val Ser Asn Ser Glu Lys Asp Ile Met 
225                 230                 235                 240 


Ala Glu Ile Tyr Lys Asn Gly Pro Val Glu Gly Ala Phe Ser Val Tyr 
                245                 250                 255     


Ser Asp Phe Leu Leu Tyr Lys Ser Gly Val Tyr Gln His Val Thr Gly 
            260                 265                 270         


Glu Met Met Gly Gly His Ala Ile Arg Ile Leu Gly Trp Gly Val Glu 
        275                 280                 285             


Asn Gly Thr Pro Tyr Trp Leu Val Ala Asn Ser Trp Asn Thr Asp Trp 
    290                 295                 300                 


Gly Asp Asn Gly Phe Phe Lys Ile Leu Arg Gly Gln Asp His Cys Gly 
305                 310                 315                 320 


Ile Glu Ser Glu Val Val Ala Gly Ile Pro Arg Thr Asp Gln Tyr Trp 
                325                 330                 335     


Glu Lys Ile 
            


<210>  3720
<211>  339
<212>  PRT
<213>  Homo Sapiens

<400>  3720

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
            100                 105                 110         


Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala His 
        115                 120                 125             


Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly Ser 
    130                 135                 140                 


Met Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp Asn 
145                 150                 155                 160 


Phe Trp Thr Arg Lys Gly Leu Val Ser Gly Gly Leu Tyr Glu Ser His 
                165                 170                 175     


Val Gly Cys Arg Pro Tyr Ser Ile Pro Pro Cys Glu His His Val Asn 
            180                 185                 190         


Gly Ser Arg Pro Pro Cys Thr Gly Glu Gly Asp Thr Pro Lys Cys Ser 
        195                 200                 205             


Lys Ile Cys Glu Pro Gly Tyr Ser Pro Thr Tyr Lys Gln Asp Lys His 
    210                 215                 220                 


Tyr Gly Tyr Asn Ser Tyr Ser Val Ser Asn Ser Glu Lys Asp Ile Met 
225                 230                 235                 240 


Ala Glu Ile Tyr Lys Asn Gly Pro Val Glu Gly Ala Phe Ser Val Tyr 
                245                 250                 255     


Ser Asp Phe Leu Leu Tyr Lys Ser Gly Val Tyr Gln His Val Thr Gly 
            260                 265                 270         


Glu Met Met Gly Gly His Ala Ile Arg Ile Leu Gly Trp Gly Val Glu 
        275                 280                 285             


Asn Gly Thr Pro Tyr Trp Leu Val Ala Asn Ser Trp Asn Thr Asp Trp 
    290                 295                 300                 


Gly Asp Asn Gly Phe Phe Lys Ile Leu Arg Gly Gln Asp His Cys Gly 
305                 310                 315                 320 


Ile Glu Ser Glu Val Val Ala Gly Ile Pro Arg Thr Asp Gln Tyr Trp 
                325                 330                 335     


Glu Lys Ile 
            


<210>  3721
<211>  339
<212>  PRT
<213>  Homo Sapiens

<400>  3721

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
            100                 105                 110         


Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala His 
        115                 120                 125             


Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly Ser 
    130                 135                 140                 


Met Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp Asn 
145                 150                 155                 160 


Phe Trp Thr Arg Lys Gly Leu Val Ser Gly Gly Leu Tyr Glu Ser His 
                165                 170                 175     


Val Gly Cys Arg Pro Tyr Ser Ile Pro Pro Cys Glu His His Val Asn 
            180                 185                 190         


Gly Ser Arg Pro Pro Cys Thr Gly Glu Gly Asp Thr Pro Lys Cys Ser 
        195                 200                 205             


Lys Ile Cys Glu Pro Gly Tyr Ser Pro Thr Tyr Lys Gln Asp Lys His 
    210                 215                 220                 


Tyr Gly Tyr Asn Ser Tyr Ser Val Ser Asn Ser Glu Lys Asp Ile Met 
225                 230                 235                 240 


Ala Glu Ile Tyr Lys Asn Gly Pro Val Glu Gly Ala Phe Ser Val Tyr 
                245                 250                 255     


Ser Asp Phe Leu Leu Tyr Lys Ser Gly Val Tyr Gln His Val Thr Gly 
            260                 265                 270         


Glu Met Met Gly Gly His Ala Ile Arg Ile Leu Gly Trp Gly Val Glu 
        275                 280                 285             


Asn Gly Thr Pro Tyr Trp Leu Val Ala Asn Ser Trp Asn Thr Asp Trp 
    290                 295                 300                 


Gly Asp Asn Gly Phe Phe Lys Ile Leu Arg Gly Gln Asp His Cys Gly 
305                 310                 315                 320 


Ile Glu Ser Glu Val Val Ala Gly Ile Pro Arg Thr Asp Gln Tyr Trp 
                325                 330                 335     


Glu Lys Ile 
            


<210>  3722
<211>  339
<212>  PRT
<213>  Homo Sapiens

<400>  3722

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
            100                 105                 110         


Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala His 
        115                 120                 125             


Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly Ser 
    130                 135                 140                 


Met Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp Asn 
145                 150                 155                 160 


Phe Trp Thr Arg Lys Gly Leu Val Ser Gly Gly Leu Tyr Glu Ser His 
                165                 170                 175     


Val Gly Cys Arg Pro Tyr Ser Ile Pro Pro Cys Glu His His Val Asn 
            180                 185                 190         


Gly Ser Arg Pro Pro Cys Thr Gly Glu Gly Asp Thr Pro Lys Cys Ser 
        195                 200                 205             


Lys Ile Cys Glu Pro Gly Tyr Ser Pro Thr Tyr Lys Gln Asp Lys His 
    210                 215                 220                 


Tyr Gly Tyr Asn Ser Tyr Ser Val Ser Asn Ser Glu Lys Asp Ile Met 
225                 230                 235                 240 


Ala Glu Ile Tyr Lys Asn Gly Pro Val Glu Gly Ala Phe Ser Val Tyr 
                245                 250                 255     


Ser Asp Phe Leu Leu Tyr Lys Ser Gly Val Tyr Gln His Val Thr Gly 
            260                 265                 270         


Glu Met Met Gly Gly His Ala Ile Arg Ile Leu Gly Trp Gly Val Glu 
        275                 280                 285             


Asn Gly Thr Pro Tyr Trp Leu Val Ala Asn Ser Trp Asn Thr Asp Trp 
    290                 295                 300                 


Gly Asp Asn Gly Phe Phe Lys Ile Leu Arg Gly Gln Asp His Cys Gly 
305                 310                 315                 320 


Ile Glu Ser Glu Val Val Ala Gly Ile Pro Arg Thr Asp Gln Tyr Trp 
                325                 330                 335     


Glu Lys Ile 
            


<210>  3723
<211>  339
<212>  PRT
<213>  Homo Sapiens

<400>  3723

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
            100                 105                 110         


Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala His 
        115                 120                 125             


Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly Ser 
    130                 135                 140                 


Met Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp Asn 
145                 150                 155                 160 


Phe Trp Thr Arg Lys Gly Leu Val Ser Gly Gly Leu Tyr Glu Ser His 
                165                 170                 175     


Val Gly Cys Arg Pro Tyr Ser Ile Pro Pro Cys Glu His His Val Asn 
            180                 185                 190         


Gly Ser Arg Pro Pro Cys Thr Gly Glu Gly Asp Thr Pro Lys Cys Ser 
        195                 200                 205             


Lys Ile Cys Glu Pro Gly Tyr Ser Pro Thr Tyr Lys Gln Asp Lys His 
    210                 215                 220                 


Tyr Gly Tyr Asn Ser Tyr Ser Val Ser Asn Ser Glu Lys Asp Ile Met 
225                 230                 235                 240 


Ala Glu Ile Tyr Lys Asn Gly Pro Val Glu Gly Ala Phe Ser Val Tyr 
                245                 250                 255     


Ser Asp Phe Leu Leu Tyr Lys Ser Gly Val Tyr Gln His Val Thr Gly 
            260                 265                 270         


Glu Met Met Gly Gly His Ala Ile Arg Ile Leu Gly Trp Gly Val Glu 
        275                 280                 285             


Asn Gly Thr Pro Tyr Trp Leu Val Ala Asn Ser Trp Asn Thr Asp Trp 
    290                 295                 300                 


Gly Asp Asn Gly Phe Phe Lys Ile Leu Arg Gly Gln Asp His Cys Gly 
305                 310                 315                 320 


Ile Glu Ser Glu Val Val Ala Gly Ile Pro Arg Thr Asp Gln Tyr Trp 
                325                 330                 335     


Glu Lys Ile 
            


<210>  3724
<211>  110
<212>  PRT
<213>  Homo Sapiens

<400>  3724

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Leu 
            100                 105                 110 


<210>  3725
<211>  76
<212>  PRT
<213>  Homo Sapiens

<400>  3725

Ser Gly Val Tyr Gln His Val Thr Gly Glu Met Met Gly Gly His Ala 
1               5                   10                  15      


Ile Arg Ile Leu Gly Trp Gly Val Glu Asn Gly Thr Pro Tyr Trp Leu 
            20                  25                  30          


Val Ala Asn Ser Trp Asn Thr Asp Trp Gly Asp Asn Gly Phe Phe Lys 
        35                  40                  45              


Ile Leu Arg Gly Gln Asp His Cys Gly Ile Glu Ser Glu Val Val Ala 
    50                  55                  60                  


Gly Ile Pro Arg Thr Asp Gln Tyr Trp Glu Lys Ile 
65                  70                  75      


<210>  3726
<211>  141
<212>  PRT
<213>  Homo Sapiens

<400>  3726

Met Gly Ala Gly Pro Ser Leu Leu Leu Ala Ala Leu Leu Leu Leu Leu 
1               5                   10                  15      


Ser Gly Asp Gly Ala Val Arg Cys Asp Thr Pro Ala Asn Cys Thr Tyr 
            20                  25                  30          


Leu Asp Leu Leu Gly Thr Trp Val Phe Gln Val Gly Ser Ser Gly Ser 
        35                  40                  45              


Gln Arg Asp Val Asn Cys Ser Val Met Gly Pro Gln Glu Lys Lys Val 
    50                  55                  60                  


Val Val Tyr Leu Gln Lys Leu Asp Thr Ala Tyr Asp Asp Leu Gly Asn 
65                  70                  75                  80  


Ser Gly His Phe Thr Ile Ile Tyr Asn Gln Gly Phe Glu Ile Val Leu 
                85                  90                  95      


Asn Asp Tyr Lys Trp Phe Ala Phe Phe Lys Asp Val Thr Asp Phe Ile 
            100                 105                 110         


Ser His Leu Phe Met Gln Leu Gly Thr Val Gly Ile Tyr Asp Leu Pro 
        115                 120                 125             


His Leu Arg Asn Lys Leu Ala Met Asn Arg Arg Trp Gly 
    130                 135                 140     


<210>  3727
<211>  137
<212>  PRT
<213>  Homo Sapiens

<400>  3727

Met Gly Ala Gly Pro Ser Leu Leu Leu Ala Ala Leu Leu Leu Leu Leu 
1               5                   10                  15      


Ser Gly Asp Gly Ala Val Arg Cys Asp Thr Pro Ala Asn Cys Thr Tyr 
            20                  25                  30          


Leu Asp Leu Leu Gly Thr Trp Val Phe Gln Val Gly Ser Ser Gly Ser 
        35                  40                  45              


Gln Arg Asp Val Asn Cys Ser Val Met Gly Pro Gln Glu Lys Lys Val 
    50                  55                  60                  


Val Val Tyr Leu Gln Lys Leu Asp Thr Ala Tyr Asp Asp Leu Gly Asn 
65                  70                  75                  80  


Ser Gly His Phe Thr Ile Ile Tyr Asn Gln Gly Phe Glu Ile Val Leu 
                85                  90                  95      


Asn Asp Tyr Lys Trp Phe Ala Phe Phe Lys Asp Val Thr Asp Phe Ile 
            100                 105                 110         


Ser His Leu Phe Met Gln Leu Gly Thr Val Gly Ile Tyr Asp Leu Pro 
        115                 120                 125             


His Leu Arg Asn Lys Leu Val Ile Lys 
    130                 135         


<210>  3728
<211>  463
<212>  PRT
<213>  Homo Sapiens

<400>  3728

Met Gly Ala Gly Pro Ser Leu Leu Leu Ala Ala Leu Leu Leu Leu Leu 
1               5                   10                  15      


Ser Gly Asp Gly Ala Val Arg Cys Asp Thr Pro Ala Asn Cys Thr Tyr 
            20                  25                  30          


Leu Asp Leu Leu Gly Thr Trp Val Phe Gln Val Gly Ser Ser Gly Ser 
        35                  40                  45              


Gln Arg Asp Val Asn Cys Ser Val Met Gly Pro Gln Glu Lys Lys Val 
    50                  55                  60                  


Val Val Tyr Leu Gln Lys Leu Asp Thr Ala Tyr Asp Asp Leu Gly Asn 
65                  70                  75                  80  


Ser Gly His Phe Thr Ile Ile Tyr Asn Gln Gly Phe Glu Ile Val Leu 
                85                  90                  95      


Asn Asp Tyr Lys Trp Phe Ala Phe Phe Lys Tyr Lys Glu Glu Gly Ser 
            100                 105                 110         


Lys Val Thr Thr Tyr Cys Asn Glu Thr Met Thr Gly Trp Val His Asp 
        115                 120                 125             


Val Leu Gly Arg Asn Trp Ala Cys Phe Thr Gly Lys Lys Val Gly Thr 
    130                 135                 140                 


Ala Ser Glu Asn Val Tyr Val Asn Ile Ala His Leu Lys Asn Ser Gln 
145                 150                 155                 160 


Glu Lys Tyr Ser Asn Arg Leu Tyr Lys Tyr Asp His Asn Phe Val Lys 
                165                 170                 175     


Ala Ile Asn Ala Ile Gln Lys Ser Trp Thr Ala Thr Thr Tyr Met Glu 
            180                 185                 190         


Tyr Glu Thr Leu Thr Leu Gly Asp Met Ile Arg Arg Ser Gly Gly His 
        195                 200                 205             


Ser Arg Lys Ile Pro Arg Pro Lys Pro Ala Pro Leu Thr Ala Glu Ile 
    210                 215                 220                 


Gln Gln Lys Ile Leu His Leu Pro Thr Ser Trp Asp Trp Arg Asn Val 
225                 230                 235                 240 


His Gly Ile Asn Phe Val Ser Pro Val Arg Asn Gln Ala Ser Cys Gly 
                245                 250                 255     


Ser Cys Tyr Ser Phe Ala Ser Met Gly Met Leu Glu Ala Arg Ile Arg 
            260                 265                 270         


Ile Leu Thr Asn Asn Ser Gln Thr Pro Ile Leu Ser Pro Gln Glu Val 
        275                 280                 285             


Val Ser Cys Ser Gln Tyr Ala Gln Gly Cys Glu Gly Gly Phe Pro Tyr 
    290                 295                 300                 


Leu Ile Ala Gly Lys Tyr Ala Gln Asp Phe Gly Leu Val Glu Glu Ala 
305                 310                 315                 320 


Cys Phe Pro Tyr Thr Gly Thr Asp Ser Pro Cys Lys Met Lys Glu Asp 
                325                 330                 335     


Cys Phe Arg Tyr Tyr Ser Ser Glu Tyr His Tyr Val Gly Gly Phe Tyr 
            340                 345                 350         


Gly Gly Cys Asn Glu Ala Leu Met Lys Leu Glu Leu Val His His Gly 
        355                 360                 365             


Pro Met Ala Val Ala Phe Glu Val Tyr Asp Asp Phe Leu His Tyr Lys 
    370                 375                 380                 


Lys Gly Ile Tyr His His Thr Gly Leu Arg Asp Pro Phe Asn Pro Phe 
385                 390                 395                 400 


Glu Leu Thr Asn His Ala Val Leu Leu Val Gly Tyr Gly Thr Asp Ser 
                405                 410                 415     


Ala Ser Gly Met Asp Tyr Trp Ile Val Lys Asn Ser Trp Gly Thr Gly 
            420                 425                 430         


Trp Gly Glu Asn Gly Tyr Phe Arg Ile Arg Arg Gly Thr Asp Glu Cys 
        435                 440                 445             


Ala Ile Glu Ser Ile Ala Val Ala Ala Thr Pro Ile Pro Lys Leu 
    450                 455                 460             


<210>  3729
<211>  36
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3729

Xaa Asp Val Thr Asp Phe Ile Ser His Leu Phe Met Gln Leu Gly Thr 
1               5                   10                  15      


Val Gly Ile Tyr Asp Leu Pro His Leu Arg Asn Lys Leu Ala Met Asn 
            20                  25                  30          


Arg Arg Trp Gly 
        35      


<210>  3730
<211>  245
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3730

Xaa Val Val Asp Ser Pro Leu Ala Arg Ser Ala Arg Leu Pro Gly Pro 
1               5                   10                  15      


Gln Glu Lys Lys Val Val Val Tyr Leu Gln Lys Leu Asp Thr Ala Tyr 
            20                  25                  30          


Asp Asp Leu Gly Asn Ser Gly His Phe Thr Ile Ile Tyr Asn Gln Gly 
        35                  40                  45              


Phe Glu Ile Val Leu Asn Asp Tyr Lys Trp Phe Ala Phe Phe Lys Tyr 
    50                  55                  60                  


Lys Glu Glu Gly Ser Lys Val Thr Thr Tyr Cys Asn Glu Thr Met Thr 
65                  70                  75                  80  


Gly Trp Val His Asp Val Leu Gly Arg Asn Trp Ala Cys Phe Thr Gly 
                85                  90                  95      


Lys Lys Val Gly Thr Ala Ser Glu Asn Val Tyr Val Asn Ile Ala His 
            100                 105                 110         


Leu Lys Asn Ser Gln Glu Lys Tyr Ser Asn Arg Leu Tyr Lys Tyr Asp 
        115                 120                 125             


His Asn Phe Val Lys Ala Ile Asn Ala Ile Gln Lys Ser Trp Thr Ala 
    130                 135                 140                 


Thr Thr Tyr Met Glu Tyr Glu Thr Leu Thr Leu Gly Asp Met Ile Arg 
145                 150                 155                 160 


Arg Ser Gly Gly His Ser Arg Lys Ile Pro Arg Pro Lys Pro Ala Pro 
                165                 170                 175     


Leu Thr Ala Glu Ile Gln Gln Lys Ile Leu His Leu Pro Thr Ser Trp 
            180                 185                 190         


Asp Trp Arg Asn Val His Gly Ile Asn Phe Val Ser Pro Val Arg Asn 
        195                 200                 205             


Gln Ala Ser Cys Gly Ser Cys Tyr Ser Phe Ala Ser Met Gly Met Leu 
    210                 215                 220                 


Glu Ala Arg Ile Arg Ile Leu Thr Asn Asn Ser Gln Thr Pro Ile Leu 
225                 230                 235                 240 


Ser Pro Gln Glu Val 
                245 


<210>  3731
<211>  299
<212>  PRT
<213>  Homo Sapiens

<400>  3731

Met Pro Arg Pro Val Val Asp Arg Ile Pro Leu His Lys Phe Thr Ser 
1               5                   10                  15      


Ile Arg Arg Thr Met Ser Glu Val Gly Gly Ser Val Glu Asp Leu Ile 
            20                  25                  30          


Ala Lys Gly Pro Val Ser Lys Tyr Ser Gln Ala Val Pro Ala Val Thr 
        35                  40                  45              


Glu Gly Pro Ile Pro Glu Val Leu Lys Asn Tyr Met Asp Ala Gln Tyr 
    50                  55                  60                  


Tyr Gly Glu Ile Gly Ile Gly Thr Pro Pro Gln Cys Phe Thr Val Val 
65                  70                  75                  80  


Phe Asp Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Ile His Cys Lys 
                85                  90                  95      


Leu Leu Asp Ile Ala Cys Trp Ile His His Lys Tyr Asn Ser Asp Lys 
            100                 105                 110         


Ser Ser Thr Tyr Val Lys Asn Gly Thr Ser Phe Asp Ile His Tyr Gly 
        115                 120                 125             


Ser Gly Ser Leu Ser Gly Tyr Leu Ser Gln Asp Thr Val Ser Val Pro 
    130                 135                 140                 


Cys Gln Ser Ala Ser Ser Ala Ser Ala Leu Gly Gly Val Lys Val Glu 
145                 150                 155                 160 


Arg Gln Val Phe Gly Glu Ala Thr Lys Gln Pro Gly Ile Thr Phe Ile 
                165                 170                 175     


Ala Ala Lys Phe Asp Gly Ile Leu Gly Met Ala Tyr Pro Arg Ile Ser 
            180                 185                 190         


Val Asn Asn Val Leu Pro Val Phe Asp Asn Leu Met Gln Gln Lys Leu 
        195                 200                 205             


Val Asp Gln Asn Ile Phe Ser Phe Tyr Leu Ser Arg Asp Pro Asp Ala 
    210                 215                 220                 


Gln Pro Gly Gly Glu Leu Met Leu Gly Gly Thr Asp Ser Lys Tyr Tyr 
225                 230                 235                 240 


Lys Gly Ser Leu Ser Tyr Leu Asn Val Thr Arg Lys Ala Tyr Trp Gln 
                245                 250                 255     


Val His Leu Asp Gln Val Glu Val Ala Ser Gly Leu Thr Leu Cys Lys 
            260                 265                 270         


Glu Gly Cys Glu Ala Ile Val Asp Thr Gly Thr Ser Leu Met Val Gly 
        275                 280                 285             


Pro Val Asp Glu Val Arg Glu Leu Gln Lys Ala 
    290                 295                 


<210>  3732
<211>  405
<212>  PRT
<213>  Homo Sapiens

<400>  3732

Met Gln Pro Ser Ser Leu Leu Pro Leu Ala Leu Cys Leu Leu Ala Ala 
1               5                   10                  15      


Pro Ala Ser Ala Leu Val Arg Ile Pro Leu His Lys Phe Thr Ser Ile 
            20                  25                  30          


Arg Arg Thr Met Ser Glu Val Gly Gly Ser Val Glu Asp Leu Ile Ala 
        35                  40                  45              


Lys Gly Pro Val Ser Lys Tyr Ser Gln Ala Val Pro Ala Val Thr Glu 
    50                  55                  60                  


Gly Pro Ile Pro Glu Ala Gln Tyr Tyr Gly Glu Ile Gly Ile Gly Thr 
65                  70                  75                  80  


Pro Pro Gln Cys Phe Thr Val Val Phe Asp Thr Gly Ser Ser Asn Leu 
                85                  90                  95      


Trp Val Pro Ser Ile His Cys Lys Leu Leu Asp Ile Ala Cys Trp Ile 
            100                 105                 110         


His His Lys Tyr Asn Ser Asp Lys Ser Ser Thr Tyr Val Lys Asn Gly 
        115                 120                 125             


Thr Ser Phe Asp Ile His Tyr Gly Ser Gly Ser Leu Ser Gly Tyr Leu 
    130                 135                 140                 


Ser Gln Asp Thr Val Ser Val Pro Cys Gln Ser Ala Ser Ser Ala Ser 
145                 150                 155                 160 


Ala Leu Gly Gly Val Lys Val Glu Arg Gln Val Phe Gly Glu Ala Thr 
                165                 170                 175     


Lys Gln Pro Gly Ile Thr Phe Ile Ala Ala Lys Phe Asp Gly Ile Leu 
            180                 185                 190         


Gly Met Ala Tyr Pro Arg Ile Ser Val Asn Asn Val Leu Pro Val Phe 
        195                 200                 205             


Asp Asn Leu Met Gln Gln Lys Leu Val Asp Gln Asn Ile Phe Ser Phe 
    210                 215                 220                 


Tyr Leu Ser Arg Asp Pro Asp Ala Gln Pro Gly Gly Glu Leu Met Leu 
225                 230                 235                 240 


Gly Gly Thr Asp Ser Lys Tyr Tyr Lys Gly Ser Leu Ser Tyr Leu Asn 
                245                 250                 255     


Val Thr Arg Lys Ala Tyr Trp Gln Val His Leu Asp Gln Val Glu Val 
            260                 265                 270         


Ala Ser Gly Leu Thr Leu Cys Lys Glu Gly Cys Glu Ala Ile Val Asp 
        275                 280                 285             


Thr Gly Thr Ser Leu Met Val Gly Pro Val Asp Glu Val Arg Glu Leu 
    290                 295                 300                 


Gln Lys Ala Ile Gly Ala Val Pro Leu Ile Gln Gly Glu Tyr Met Ile 
305                 310                 315                 320 


Pro Cys Glu Lys Val Ser Thr Leu Pro Ala Ile Thr Leu Lys Leu Gly 
                325                 330                 335     


Gly Lys Gly Tyr Lys Leu Ser Pro Glu Asp Tyr Thr Leu Lys Val Ser 
            340                 345                 350         


Gln Ala Gly Lys Thr Leu Cys Leu Ser Gly Phe Met Gly Met Asp Ile 
        355                 360                 365             


Pro Pro Pro Ser Gly Pro Leu Trp Ile Leu Gly Asp Val Phe Ile Gly 
    370                 375                 380                 


Arg Tyr Tyr Thr Val Phe Asp Arg Asp Asn Asn Arg Val Gly Phe Ala 
385                 390                 395                 400 


Glu Ala Ala Arg Leu 
                405 


<210>  3733
<211>  412
<212>  PRT
<213>  Homo Sapiens

<400>  3733

Met Gln Pro Ser Ser Leu Leu Pro Leu Ala Leu Cys Leu Leu Ala Ala 
1               5                   10                  15      


Pro Ala Ser Ala Leu Val Arg Ile Pro Leu His Lys Phe Thr Ser Ile 
            20                  25                  30          


Arg Arg Thr Met Ser Glu Val Gly Gly Ser Val Glu Asp Leu Ile Ala 
        35                  40                  45              


Lys Gly Pro Val Ser Lys Tyr Ser Gln Ala Val Pro Ala Val Thr Glu 
    50                  55                  60                  


Gly Pro Ile Pro Glu Val Leu Lys Asn Tyr Met Asp Ala Gln Tyr Tyr 
65                  70                  75                  80  


Gly Glu Ile Gly Ile Gly Thr Pro Pro Gln Cys Phe Thr Val Val Phe 
                85                  90                  95      


Asp Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Ile His Cys Lys Leu 
            100                 105                 110         


Leu Asp Ile Ala Cys Trp Ile His His Lys Tyr Asn Ser Asp Lys Ser 
        115                 120                 125             


Ser Thr Tyr Val Lys Asn Gly Thr Ser Phe Asp Ile His Tyr Gly Ser 
    130                 135                 140                 


Gly Ser Leu Ser Gly Tyr Leu Ser Gln Asp Thr Val Ser Val Pro Cys 
145                 150                 155                 160 


Gln Ser Ala Ser Ser Ala Ser Ala Leu Gly Gly Val Lys Val Glu Arg 
                165                 170                 175     


Gln Val Phe Gly Glu Ala Thr Lys Gln Pro Gly Ile Thr Phe Ile Ala 
            180                 185                 190         


Ala Lys Phe Asp Gly Ile Leu Gly Met Ala Tyr Pro Arg Ile Ser Val 
        195                 200                 205             


Asn Asn Val Leu Pro Val Phe Asp Asn Leu Met Gln Gln Lys Leu Val 
    210                 215                 220                 


Asp Gln Asn Ile Phe Ser Phe Tyr Leu Ser Arg Asp Pro Asp Ala Gln 
225                 230                 235                 240 


Pro Gly Gly Glu Leu Met Leu Gly Gly Thr Asp Ser Lys Tyr Tyr Lys 
                245                 250                 255     


Gly Ser Leu Ser Tyr Leu Asn Val Thr Arg Lys Ala Tyr Trp Gln Val 
            260                 265                 270         


His Leu Asp Gln Val Glu Val Ala Ser Gly Leu Thr Leu Cys Lys Glu 
        275                 280                 285             


Gly Cys Glu Ala Ile Val Asp Thr Gly Thr Ser Leu Met Val Gly Pro 
    290                 295                 300                 


Val Asp Glu Val Arg Glu Leu Gln Lys Ala Ile Gly Ala Val Pro Leu 
305                 310                 315                 320 


Ile Gln Gly Glu Tyr Met Ile Pro Cys Glu Lys Val Ser Thr Leu Pro 
                325                 330                 335     


Ala Ile Thr Leu Lys Leu Gly Gly Lys Gly Tyr Lys Leu Ser Pro Glu 
            340                 345                 350         


Asp Tyr Thr Leu Lys Val Ser Gln Ala Gly Lys Thr Leu Cys Leu Ser 
        355                 360                 365             


Gly Phe Met Gly Met Asp Ile Pro Pro Pro Ser Gly Pro Leu Trp Ile 
    370                 375                 380                 


Leu Gly Asp Val Phe Ile Gly Arg Tyr Tyr Thr Val Phe Asp Arg Asp 
385                 390                 395                 400 


Asn Asn Arg Val Gly Phe Ala Glu Ala Ala Arg Leu 
                405                 410         


<210>  3734
<211>  276
<212>  PRT
<213>  Homo Sapiens

<400>  3734

Met Gln Pro Ser Ser Leu Leu Pro Leu Ala Leu Cys Leu Leu Ala Ala 
1               5                   10                  15      


Pro Ala Ser Ala Leu Val Arg Ile Pro Leu His Lys Phe Thr Ser Ile 
            20                  25                  30          


Arg Arg Thr Met Ser Glu Val Gly Gly Ser Val Glu Asp Leu Ile Ala 
        35                  40                  45              


Lys Gly Pro Val Ser Lys Tyr Ser Gln Ala Val Pro Ala Val Thr Glu 
    50                  55                  60                  


Gly Pro Ile Pro Glu Val Leu Lys Asn Tyr Met Asp Ala Gln Tyr Tyr 
65                  70                  75                  80  


Gly Glu Ile Gly Ile Gly Thr Pro Pro Gln Cys Phe Thr Val Val Phe 
                85                  90                  95      


Asp Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Ile His Cys Lys Leu 
            100                 105                 110         


Leu Asp Ile Ala Cys Trp Ile His His Lys Tyr Asn Ser Asp Lys Ser 
        115                 120                 125             


Ser Thr Tyr Val Lys Asn Gly Thr Ser Phe Asp Ile His Tyr Gly Ser 
    130                 135                 140                 


Gly Ser Leu Ser Gly Tyr Leu Ser Gln Asp Thr Val Ser Val Pro Cys 
145                 150                 155                 160 


Gln Ser Ala Ser Ser Ala Ser Ala Leu Gly Gly Val Lys Val Glu Arg 
                165                 170                 175     


Gln Val Phe Gly Glu Ala Thr Lys Gln Pro Gly Ile Thr Phe Ile Ala 
            180                 185                 190         


Ala Lys Phe Asp Gly Ile Leu Gly Met Ala Tyr Pro Arg Ile Ser Val 
        195                 200                 205             


Asn Asn Val Leu Pro Val Phe Asp Asn Leu Met Gln Gln Lys Leu Val 
    210                 215                 220                 


Asp Gln Asn Ile Phe Ser Phe Tyr Leu Ser Arg Asp Pro Asp Ala Gln 
225                 230                 235                 240 


Pro Gly Gly Glu Leu Met Leu Gly Gly Thr Asp Ser Lys Tyr Tyr Lys 
                245                 250                 255     


Gly Ser Leu Ser Tyr Leu Asn Val Thr Arg Lys Ala Tyr Trp Gln Val 
            260                 265                 270         


His Leu Asp Gln 
        275     


<210>  3735
<211>  406
<212>  PRT
<213>  Homo Sapiens

<400>  3735

Met Gln Pro Ser Ser Leu Leu Pro Leu Ala Leu Cys Leu Leu Ala Ala 
1               5                   10                  15      


Pro Ala Ser Ala Leu Val Arg Ile Pro Leu His Lys Phe Thr Ser Ile 
            20                  25                  30          


Arg Arg Thr Met Ser Glu Val Gly Gly Ser Val Glu Asp Leu Ile Ala 
        35                  40                  45              


Lys Gly Pro Val Ser Lys Tyr Ser Gln Ala Val Pro Ala Val Thr Glu 
    50                  55                  60                  


Gly Pro Ile Pro Glu Val Leu Lys Asn Tyr Met Asp Ala Gln Tyr Tyr 
65                  70                  75                  80  


Gly Glu Ile Gly Ile Gly Thr Pro Pro Gln Cys Phe Thr Val Val Phe 
                85                  90                  95      


Asp Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Ile His Cys Lys Leu 
            100                 105                 110         


Leu Asp Ile Ala Cys Trp Ile His His Lys Tyr Asn Ser Asp Lys Ser 
        115                 120                 125             


Ser Thr Tyr Val Lys Asn Gly Thr Ser Phe Asp Ile His Tyr Gly Ser 
    130                 135                 140                 


Gly Ser Leu Ser Gly Tyr Leu Ser Gln Asp Thr Val Ser Val Pro Cys 
145                 150                 155                 160 


Gln Ser Ala Ser Ser Ala Ser Ala Leu Gly Gly Val Lys Val Glu Arg 
                165                 170                 175     


Gln Val Phe Gly Glu Ala Thr Lys Gln Pro Gly Ile Thr Phe Ile Ala 
            180                 185                 190         


Ala Lys Phe Asp Gly Ile Leu Gly Met Ala Tyr Pro Arg Ile Ser Val 
        195                 200                 205             


Asn Asn Val Leu Pro Val Phe Asp Asn Leu Met Gln Gln Lys Leu Val 
    210                 215                 220                 


Asp Gln Asn Ile Phe Ser Phe Tyr Leu Ser Arg Asp Pro Asp Ala Gln 
225                 230                 235                 240 


Pro Gly Gly Glu Leu Met Leu Gly Gly Thr Asp Ser Lys Tyr Tyr Lys 
                245                 250                 255     


Gly Ser Leu Ser Tyr Leu Asn Val Thr Arg Lys Ala Tyr Trp Val Glu 
            260                 265                 270         


Val Ala Ser Gly Leu Thr Leu Cys Lys Glu Gly Cys Glu Ala Ile Val 
        275                 280                 285             


Asp Thr Gly Thr Ser Leu Met Val Gly Pro Val Asp Glu Val Arg Glu 
    290                 295                 300                 


Leu Gln Lys Ala Ile Gly Ala Val Pro Leu Ile Gln Gly Glu Tyr Met 
305                 310                 315                 320 


Ile Pro Cys Glu Lys Val Ser Thr Leu Pro Ala Ile Thr Leu Lys Leu 
                325                 330                 335     


Gly Gly Lys Gly Tyr Lys Leu Ser Pro Glu Asp Tyr Thr Leu Lys Val 
            340                 345                 350         


Ser Gln Ala Gly Lys Thr Leu Cys Leu Ser Gly Phe Met Gly Met Asp 
        355                 360                 365             


Ile Pro Pro Pro Ser Gly Pro Leu Trp Ile Leu Gly Asp Val Phe Ile 
    370                 375                 380                 


Gly Arg Tyr Tyr Thr Val Phe Asp Arg Asp Asn Asn Arg Val Gly Phe 
385                 390                 395                 400 


Ala Glu Ala Ala Arg Leu 
                405     


<210>  3736
<211>  405
<212>  PRT
<213>  Homo Sapiens

<400>  3736

Met Gln Pro Ser Ser Leu Leu Pro Leu Ala Leu Cys Leu Leu Ala Ala 
1               5                   10                  15      


Pro Ala Ser Ala Leu Val Arg Ile Pro Leu His Lys Phe Thr Ser Ile 
            20                  25                  30          


Arg Arg Thr Met Ser Glu Val Gly Gly Ser Val Glu Asp Leu Ile Ala 
        35                  40                  45              


Lys Gly Pro Val Ser Lys Tyr Ser Gln Ala Val Pro Ala Val Thr Glu 
    50                  55                  60                  


Gly Pro Ile Pro Glu Val Leu Lys Asn Tyr Met Asp Ala Gln Tyr Tyr 
65                  70                  75                  80  


Gly Glu Ile Gly Ile Gly Thr Pro Pro Gln Cys Phe Thr Val Val Phe 
                85                  90                  95      


Asp Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Ile His Cys Lys Leu 
            100                 105                 110         


Leu Asp Ile Ala Cys Trp Ile His His Lys Tyr Asn Ser Asp Lys Ser 
        115                 120                 125             


Ser Thr Tyr Val Lys Asn Gly Thr Ser Phe Asp Ile His Tyr Gly Ser 
    130                 135                 140                 


Gly Ser Leu Ser Gly Tyr Leu Ser Gln Asp Thr Val Ser Val Pro Cys 
145                 150                 155                 160 


Gln Ser Ala Ser Ser Ala Ser Ala Leu Gly Gly Val Lys Val Glu Arg 
                165                 170                 175     


Gln Val Phe Gly Glu Ala Thr Lys Gln Pro Gly Ile Thr Phe Ile Ala 
            180                 185                 190         


Ala Lys Phe Asp Gly Ile Leu Gly Met Ala Tyr Pro Arg Ile Ser Val 
        195                 200                 205             


Asn Asn Val Leu Pro Val Phe Asp Asn Leu Met Gln Gln Lys Leu Val 
    210                 215                 220                 


Asp Gln Asn Ile Phe Ser Phe Tyr Leu Ser Arg Asp Pro Asp Ala Gln 
225                 230                 235                 240 


Pro Gly Gly Glu Leu Met Leu Gly Gly Thr Asp Ser Lys Tyr Tyr Lys 
                245                 250                 255     


Gly Ser Leu Ser Tyr Leu Asn Val Thr Arg Lys Ala Tyr Trp Gln Val 
            260                 265                 270         


His Leu Asp Gln Val Glu Val Ala Ser Gly Leu Thr Leu Cys Lys Glu 
        275                 280                 285             


Gly Cys Glu Ala Ile Val Asp Thr Gly Thr Ser Leu Met Val Gly Pro 
    290                 295                 300                 


Val Asp Glu Val Arg Glu Leu Gln Lys Ala Ile Gly Ala Val Pro Leu 
305                 310                 315                 320 


Ile Gln Gly Glu Val Ser Thr Leu Pro Ala Ile Thr Leu Lys Leu Gly 
                325                 330                 335     


Gly Lys Gly Tyr Lys Leu Ser Pro Glu Asp Tyr Thr Leu Lys Val Ser 
            340                 345                 350         


Gln Ala Gly Lys Thr Leu Cys Leu Ser Gly Phe Met Gly Met Asp Ile 
        355                 360                 365             


Pro Pro Pro Ser Gly Pro Leu Trp Ile Leu Gly Asp Val Phe Ile Gly 
    370                 375                 380                 


Arg Tyr Tyr Thr Val Phe Asp Arg Asp Asn Asn Arg Val Gly Phe Ala 
385                 390                 395                 400 


Glu Ala Ala Arg Leu 
                405 


<210>  3737
<211>  409
<212>  PRT
<213>  Homo Sapiens

<400>  3737

Met Gln Pro Ser Ser Leu Leu Pro Leu Ala Leu Cys Leu Leu Ala Ala 
1               5                   10                  15      


Pro Ala Ser Ala Leu Val Arg Ile Pro Leu His Lys Phe Thr Ser Ile 
            20                  25                  30          


Arg Arg Thr Met Ser Glu Val Gly Gly Ser Val Glu Asp Leu Ile Ala 
        35                  40                  45              


Lys Gly Pro Val Ser Lys Tyr Ser Gln Ala Val Pro Ala Val Thr Glu 
    50                  55                  60                  


Gly Pro Ile Pro Glu Val Leu Lys Asn Tyr Met Asp Ala Gln Tyr Tyr 
65                  70                  75                  80  


Gly Glu Ile Gly Ile Gly Thr Pro Pro Gln Cys Phe Thr Val Val Phe 
                85                  90                  95      


Asp Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Ile His Cys Lys Leu 
            100                 105                 110         


Leu Asp Ile Ala Cys Trp Ile His His Lys Tyr Asn Ser Asp Lys Ser 
        115                 120                 125             


Ser Thr Tyr Val Lys Asn Gly Thr Ser Phe Asp Ile His Tyr Gly Ser 
    130                 135                 140                 


Gly Ser Leu Ser Gly Tyr Leu Ser Gln Asp Thr Val Ser Val Pro Cys 
145                 150                 155                 160 


Gln Ser Ala Ser Ser Ala Ser Ala Leu Gly Gly Val Lys Val Glu Arg 
                165                 170                 175     


Gln Val Phe Gly Glu Ala Thr Lys Gln Pro Gly Ile Thr Phe Ile Ala 
            180                 185                 190         


Ala Lys Phe Asp Gly Ile Leu Gly Met Ala Tyr Pro Arg Ile Ser Val 
        195                 200                 205             


Asn Asn Val Leu Pro Val Phe Asp Asn Leu Met Gln Gln Lys Leu Val 
    210                 215                 220                 


Asp Gln Asn Ile Phe Ser Phe Tyr Leu Ser Arg Asp Pro Asp Ala Gln 
225                 230                 235                 240 


Pro Gly Gly Glu Leu Met Leu Gly Gly Thr Asp Ser Lys Tyr Tyr Lys 
                245                 250                 255     


Gly Ser Leu Ser Tyr Leu Asn Val Thr Arg Lys Ala Tyr Trp Gln Val 
            260                 265                 270         


His Leu Asp Gln Val Glu Val Ala Ser Gly Leu Thr Leu Cys Lys Glu 
        275                 280                 285             


Gly Cys Glu Ala Ile Val Asp Thr Gly Thr Ser Leu Met Val Gly Pro 
    290                 295                 300                 


Val Asp Glu Val Arg Glu Leu Gln Lys Ala Ile Gly Ala Val Pro Leu 
305                 310                 315                 320 


Ile Gln Gly Glu Tyr Met Ile Pro Cys Glu Lys Val Ser Thr Leu Pro 
                325                 330                 335     


Ala Ile Thr Leu Lys Leu Gly Gly Lys Gly Tyr Lys Leu Ser Pro Glu 
            340                 345                 350         


Asp Tyr Thr Leu Lys Ala Gly Lys Thr Leu Cys Leu Ser Gly Phe Met 
        355                 360                 365             


Gly Met Asp Ile Pro Pro Pro Ser Gly Pro Leu Trp Ile Leu Gly Asp 
    370                 375                 380                 


Val Phe Ile Gly Arg Tyr Tyr Thr Val Phe Asp Arg Asp Asn Asn Arg 
385                 390                 395                 400 


Val Gly Phe Ala Glu Ala Ala Arg Leu 
                405                 


<210>  3738
<211>  410
<212>  PRT
<213>  Homo Sapiens

<400>  3738

Met Gln Pro Ser Ser Leu Leu Pro Leu Ala Leu Cys Leu Leu Ala Ala 
1               5                   10                  15      


Pro Ala Ser Ala Leu Val Arg Ile Pro Leu His Lys Phe Thr Ser Ile 
            20                  25                  30          


Arg Arg Thr Met Ser Glu Val Gly Gly Ser Val Glu Asp Leu Ile Ala 
        35                  40                  45              


Lys Gly Pro Val Ser Lys Tyr Ser Gln Ala Val Pro Ala Val Thr Glu 
    50                  55                  60                  


Gly Pro Ile Pro Glu Val Leu Lys Asn Tyr Met Asp Tyr Tyr Gly Glu 
65                  70                  75                  80  


Ile Gly Ile Gly Thr Pro Pro Gln Cys Phe Thr Val Val Phe Asp Thr 
                85                  90                  95      


Gly Ser Ser Asn Leu Trp Val Pro Ser Ile His Cys Lys Leu Leu Asp 
            100                 105                 110         


Ile Ala Cys Trp Ile His His Lys Tyr Asn Ser Asp Lys Ser Ser Thr 
        115                 120                 125             


Tyr Val Lys Asn Gly Thr Ser Phe Asp Ile His Tyr Gly Ser Gly Ser 
    130                 135                 140                 


Leu Ser Gly Tyr Leu Ser Gln Asp Thr Val Ser Val Pro Cys Gln Ser 
145                 150                 155                 160 


Ala Ser Ser Ala Ser Ala Leu Gly Gly Val Lys Val Glu Arg Gln Val 
                165                 170                 175     


Phe Gly Glu Ala Thr Lys Gln Pro Gly Ile Thr Phe Ile Ala Ala Lys 
            180                 185                 190         


Phe Asp Gly Ile Leu Gly Met Ala Tyr Pro Arg Ile Ser Val Asn Asn 
        195                 200                 205             


Val Leu Pro Val Phe Asp Asn Leu Met Gln Gln Lys Leu Val Asp Gln 
    210                 215                 220                 


Asn Ile Phe Ser Phe Tyr Leu Ser Arg Asp Pro Asp Ala Gln Pro Gly 
225                 230                 235                 240 


Gly Glu Leu Met Leu Gly Gly Thr Asp Ser Lys Tyr Tyr Lys Gly Ser 
                245                 250                 255     


Leu Ser Tyr Leu Asn Val Thr Arg Lys Ala Tyr Trp Gln Val His Leu 
            260                 265                 270         


Asp Gln Val Glu Val Ala Ser Gly Leu Thr Leu Cys Lys Glu Gly Cys 
        275                 280                 285             


Glu Ala Ile Val Asp Thr Gly Thr Ser Leu Met Val Gly Pro Val Asp 
    290                 295                 300                 


Glu Val Arg Glu Leu Gln Lys Ala Ile Gly Ala Val Pro Leu Ile Gln 
305                 310                 315                 320 


Gly Glu Tyr Met Ile Pro Cys Glu Lys Val Ser Thr Leu Pro Ala Ile 
                325                 330                 335     


Thr Leu Lys Leu Gly Gly Lys Gly Tyr Lys Leu Ser Pro Glu Asp Tyr 
            340                 345                 350         


Thr Leu Lys Val Ser Gln Ala Gly Lys Thr Leu Cys Leu Ser Gly Phe 
        355                 360                 365             


Met Gly Met Asp Ile Pro Pro Pro Ser Gly Pro Leu Trp Ile Leu Gly 
    370                 375                 380                 


Asp Val Phe Ile Gly Arg Tyr Tyr Thr Val Phe Asp Arg Asp Asn Asn 
385                 390                 395                 400 


Arg Val Gly Phe Ala Glu Ala Ala Arg Leu 
                405                 410 


<210>  3739
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  3739

Met Ser Glu Val Gly Gly Ser Val Glu Asp Leu Ile Ala Lys Gly Pro 
1               5                   10                  15      


Val Ser Lys Tyr Ser Gln Ala Val Pro Ala Val Thr Glu Gly Pro Ile 
            20                  25                  30          


Pro Glu Val Leu Lys Asn Tyr Met Asp Ala Gln Tyr Tyr Gly Glu Ile 
        35                  40                  45              


Gly Ile Gly Thr Pro Pro Gln Cys Phe Thr Val Val Phe Asp Thr Gly 
    50                  55                  60                  


Ser Ser Asn Leu Trp Val Pro Ser Ile His Cys Lys Leu Leu Asp Ile 
65                  70                  75                  80  


Ala Cys Trp Ile His His Lys Tyr Asn Ser Asp Lys Ser Ser 
                85                  90                  


<210>  3740
<211>  199
<212>  PRT
<213>  Homo Sapiens

<400>  3740

Met Ser Glu Val Gly Gly Ser Val Glu Asp Leu Ile Ala Lys Gly Pro 
1               5                   10                  15      


Val Ser Lys Tyr Ser Gln Ala Val Pro Ala Val Thr Glu Gly Pro Ile 
            20                  25                  30          


Pro Glu Val Leu Lys Asn Tyr Met Asp Ala Gln Tyr Tyr Gly Glu Ile 
        35                  40                  45              


Gly Ile Gly Thr Pro Pro Gln Cys Phe Thr Val Val Phe Asp Thr Gly 
    50                  55                  60                  


Ser Ser Asn Leu Trp Val Pro Ser Ile His Cys Lys Leu Leu Asp Ile 
65                  70                  75                  80  


Ala Cys Trp Ile His His Lys Tyr Asn Ser Asp Lys Ser Ser Thr Tyr 
                85                  90                  95      


Val Lys Asn Gly Thr Ser Phe Asp Ile His Tyr Gly Ser Gly Ser Leu 
            100                 105                 110         


Ser Gly Tyr Leu Ser Gln Asp Thr Val Ser Val Pro Cys Gln Ser Ala 
        115                 120                 125             


Ser Ser Ala Ser Ala Leu Gly Gly Val Lys Val Glu Arg Gln Val Phe 
    130                 135                 140                 


Gly Glu Ala Thr Lys Gln Pro Gly Ile Thr Phe Ile Ala Ala Lys Phe 
145                 150                 155                 160 


Asp Gly Ile Leu Gly Met Ala Tyr Pro Arg Ile Ser Val Asn Asn Val 
                165                 170                 175     


Leu Pro Val Phe Asp Asn Leu Met Gln Gln Lys Leu Val Asp Gln Asn 
            180                 185                 190         


Ile Phe Ser Phe Tyr Leu Ser 
        195                 


<210>  3741
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  3741

Asn Val Thr Arg Lys Ala Tyr Trp Gln Val His Leu Asp Gln Ser Pro 
1               5                   10                  15      


Glu Gly Arg Arg Val Gln Pro Ser Gln Gly Arg Gly Ser Gln Gly Gly 
            20                  25                  30          


Ala Leu Gly Pro Gln Gly Thr Leu Gln Ser Arg Gln Gly Leu His Ala 
        35                  40                  45              


Leu Thr Pro Arg Arg Val Glu Val Ala Ser Gly Leu Thr Leu Cys Lys 
    50                  55                  60                  


Glu Gly Cys Glu Ala Ile Val Asp Thr Gly Thr Ser Leu Met Val Gly 
65                  70                  75                  80  


Pro Val Asp Glu Val Arg Glu Leu Gln Lys Ala Ile Gly Ala Val Pro 
                85                  90                  95      


Leu Ile Gln Gly Glu Tyr Met Ile Pro Cys Glu Lys Val Ser Thr Leu 
            100                 105                 110         


Pro Ala Ile Thr Leu Lys Leu Gly Gly Lys Gly Tyr Lys Leu Ser Pro 
        115                 120                 125             


Glu Asp Tyr Thr Leu Lys Val Ser Gln Ala Gly Lys Thr Leu Cys Leu 
    130                 135                 140                 


Ser Gly Phe Met Gly Met Asp Ile Pro Pro Pro Ser Gly Pro Leu Trp 
145                 150                 155                 160 


Ile Leu Gly Asp Val Phe Ile Gly Arg Tyr Tyr Thr Val Phe Asp Arg 
                165                 170                 175     


Asp Asn Asn Arg Val Gly Phe Ala Glu Ala Ala Arg Leu 
            180                 185                 


<210>  3742
<211>  396
<212>  PRT
<213>  Homo Sapiens

<400>  3742

Met Lys Thr Leu Leu Leu Leu Leu Leu Val Leu Leu Glu Leu Gly Glu 
1               5                   10                  15      


Ala Gln Gly Ser Leu His Arg Val Pro Leu Arg Arg His Pro Ser Leu 
            20                  25                  30          


Lys Lys Lys Leu Arg Ala Arg Ser Gln Leu Ser Glu Phe Trp Lys Ser 
        35                  40                  45              


His Asn Leu Asp Met Ile Gln Phe Thr Glu Ser Cys Ser Met Asp Gln 
    50                  55                  60                  


Ser Ala Lys Glu Pro Leu Ile Asn Tyr Leu Asp Met Glu Tyr Phe Gly 
65                  70                  75                  80  


Thr Ile Ser Ile Gly Ser Pro Pro Gln Asn Phe Thr Val Ile Phe Asp 
                85                  90                  95      


Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Val Tyr Cys Thr Ser Pro 
            100                 105                 110         


Ala Cys Lys Thr His Ser Arg Phe Gln Pro Ser Gln Ser Ser Thr Tyr 
        115                 120                 125             


Ser Gln Pro Gly Gln Ser Phe Ser Ile Gln Tyr Gly Thr Gly Ser Leu 
    130                 135                 140                 


Ser Gly Ile Ile Gly Ala Asp Gln Val Ser Val Glu Gly Leu Thr Val 
145                 150                 155                 160 


Val Gly Gln Gln Phe Gly Glu Ser Val Thr Glu Pro Gly Gln Thr Phe 
                165                 170                 175     


Val Asp Ala Glu Phe Asp Gly Ile Leu Gly Leu Gly Tyr Pro Ser Leu 
            180                 185                 190         


Ala Val Gly Gly Val Thr Pro Val Phe Asp Asn Met Met Ala Gln Asn 
        195                 200                 205             


Leu Val Asp Leu Pro Met Phe Ser Val Tyr Met Ser Ser Asn Pro Glu 
    210                 215                 220                 


Gly Gly Ala Gly Ser Glu Leu Ile Phe Gly Gly Tyr Asp His Ser His 
225                 230                 235                 240 


Phe Ser Gly Ser Leu Asn Trp Val Pro Val Thr Lys Gln Ala Tyr Trp 
                245                 250                 255     


Gln Ile Ala Leu Asp Asn Ile Gln Val Gly Gly Thr Val Met Phe Cys 
            260                 265                 270         


Ser Glu Gly Cys Gln Ala Ile Val Asp Thr Gly Thr Ser Leu Ile Thr 
        275                 280                 285             


Gly Pro Ser Asp Lys Ile Lys Gln Leu Gln Asn Ala Ile Gly Ala Ala 
    290                 295                 300                 


Pro Val Asp Gly Glu Tyr Ala Val Glu Cys Ala Asn Leu Asn Val Met 
305                 310                 315                 320 


Pro Asp Val Thr Phe Thr Ile Asn Gly Val Pro Tyr Thr Leu Ser Pro 
                325                 330                 335     


Thr Ala Tyr Thr Leu Leu Asp Phe Val Asp Gly Met Gln Phe Cys Ser 
            340                 345                 350         


Ser Gly Phe Gln Gly Leu Asp Ile His Pro Pro Ala Gly Pro Leu Trp 
        355                 360                 365             


Ile Leu Gly Asp Val Phe Ile Arg Gln Phe Tyr Ser Val Phe Asp Arg 
    370                 375                 380                 


Gly Asn Asn Arg Val Gly Leu Ala Pro Ala Val Pro 
385                 390                 395     


<210>  3743
<211>  363
<212>  PRT
<213>  Homo Sapiens

<400>  3743

Met Lys Thr Leu Leu Leu Leu Leu Leu Val Leu Leu Glu Leu Gly Glu 
1               5                   10                  15      


Ala Gln Gly Ser Leu His Arg Val Pro Leu Arg Arg His Pro Ser Leu 
            20                  25                  30          


Lys Lys Lys Leu Arg Ala Arg Ser Gln Leu Ser Glu Phe Trp Lys Ser 
        35                  40                  45              


His Asn Leu Asp Met Ile Gln Phe Thr Glu Ser Cys Ser Met Asp Gln 
    50                  55                  60                  


Ser Ala Lys Glu Pro Leu Ile Asn Tyr Leu Asp Met Glu Tyr Phe Gly 
65                  70                  75                  80  


Thr Ile Ser Ile Gly Ser Pro Pro Gln Asn Phe Thr Val Ile Phe Asp 
                85                  90                  95      


Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Val Tyr Cys Thr Ser Pro 
            100                 105                 110         


Ala Cys Lys Thr His Ser Arg Phe Gln Pro Ser Gln Ser Ser Thr Tyr 
        115                 120                 125             


Ser Gln Pro Gly Gln Ser Phe Ser Ile Gln Tyr Gly Thr Gly Ser Leu 
    130                 135                 140                 


Ser Gly Ile Ile Gly Ala Asp Gln Val Ser Val Glu Gly Leu Thr Val 
145                 150                 155                 160 


Val Gly Gln Gln Phe Gly Glu Ser Val Thr Glu Pro Gly Gln Thr Phe 
                165                 170                 175     


Val Asp Ala Glu Phe Asp Gly Ile Leu Gly Leu Gly Tyr Pro Ser Leu 
            180                 185                 190         


Ala Val Gly Gly Val Thr Pro Val Phe Asp Asn Met Met Ala Gln Asn 
        195                 200                 205             


Leu Val Asp Leu Pro Met Phe Ser Val Tyr Met Ser Ser Asn Pro Glu 
    210                 215                 220                 


Gly Gly Ala Gly Ser Glu Leu Ile Phe Gly Gly Tyr Asp His Ser His 
225                 230                 235                 240 


Phe Ser Gly Ser Leu Asn Trp Val Pro Val Thr Lys Gln Ala Tyr Trp 
                245                 250                 255     


Gln Ile Ala Leu Asp Asn Met Leu Trp Ser Val Pro Thr Leu Thr Ser 
            260                 265                 270         


Cys Arg Met Ser Pro Ser Pro Leu Thr Glu Ser Pro Ile Pro Ser Ala 
        275                 280                 285             


Gln Leu Pro Thr Pro Tyr Trp Thr Ser Trp Met Glu Cys Ser Ser Ala 
    290                 295                 300                 


Ala Val Ala Phe Lys Asp Leu Thr Ser Thr Leu Gln Leu Gly Pro Ser 
305                 310                 315                 320 


Gly Ser Trp Gly Met Ser Ser Phe Asp Ser Phe Thr Gln Ser Leu Thr 
                325                 330                 335     


Val Gly Ile Thr Val Trp Asp Trp Pro Gln Gln Ser Pro Lys Glu Gly 
            340                 345                 350         


Pro Cys Val Cys Ala Cys Leu Ser Asp Arg Pro 
        355                 360             


<210>  3744
<211>  484
<212>  PRT
<213>  Homo Sapiens

<400>  3744

Met Ala Pro Trp Leu Gln Leu Leu Ser Leu Leu Gly Leu Leu Pro Gly 
1               5                   10                  15      


Ala Val Ala Ala Pro Ala Gln Pro Arg Ala Ala Ser Phe Gln Ala Trp 
            20                  25                  30          


Gly Pro Pro Ser Pro Glu Leu Leu Ala Pro Thr Arg Phe Ala Leu Glu 
        35                  40                  45              


Met Phe Asn Arg Gly Arg Ala Ala Gly Thr Arg Ala Val Leu Gly Leu 
    50                  55                  60                  


Val Arg Gly Arg Val Arg Arg Ala Gly Gln Gly Ser Leu Tyr Ser Leu 
65                  70                  75                  80  


Glu Ala Thr Leu Glu Glu Pro Pro Cys Asn Asp Pro Met Val Cys Arg 
                85                  90                  95      


Leu Pro Val Ser Lys Lys Thr Leu Leu Cys Ser Phe Gln Val Leu Asp 
            100                 105                 110         


Glu Leu Gly Arg His Val Leu Leu Arg Lys Asp Cys Gly Pro Val Asp 
        115                 120                 125             


Thr Lys Val Pro Gly Ala Gly Glu Pro Lys Ser Ala Phe Thr Gln Gly 
    130                 135                 140                 


Ser Ala Met Ile Ser Ser Leu Ser Gln Asn His Pro Asp Asn Arg Asn 
145                 150                 155                 160 


Glu Thr Phe Ser Ser Val Ile Ser Leu Leu Asn Glu Asp Pro Leu Ser 
                165                 170                 175     


Gln Asp Leu Pro Val Lys Met Ala Ser Ile Phe Lys Asn Phe Val Ile 
            180                 185                 190         


Thr Tyr Asn Arg Thr Tyr Glu Ser Lys Glu Glu Ala Arg Trp Arg Leu 
        195                 200                 205             


Ser Val Phe Val Asn Asn Met Val Arg Ala Gln Lys Ile Gln Ala Leu 
    210                 215                 220                 


Asp Arg Gly Thr Ala Gln Tyr Gly Val Thr Lys Phe Ser Asp Leu Thr 
225                 230                 235                 240 


Glu Glu Glu Phe Arg Thr Ile Tyr Leu Asn Thr Leu Leu Arg Lys Glu 
                245                 250                 255     


Pro Gly Asn Lys Met Lys Gln Ala Lys Ser Val Gly Asp Leu Ala Pro 
            260                 265                 270         


Pro Glu Trp Asp Trp Arg Ser Lys Gly Ala Val Thr Lys Val Lys Asp 
        275                 280                 285             


Gln Gly Met Cys Gly Ser Cys Trp Ala Phe Ser Val Thr Gly Asn Val 
    290                 295                 300                 


Glu Gly Gln Trp Phe Leu Asn Gln Gly Thr Leu Leu Ser Leu Ser Glu 
305                 310                 315                 320 


Gln Glu Leu Leu Asp Cys Asp Lys Met Asp Lys Ala Cys Met Gly Gly 
                325                 330                 335     


Leu Pro Ser Asn Ala Tyr Ser Ala Ile Lys Asn Leu Gly Gly Leu Glu 
            340                 345                 350         


Thr Glu Asp Asp Tyr Ser Tyr Gln Gly His Met Gln Ser Cys Asn Phe 
        355                 360                 365             


Ser Ala Glu Lys Ala Lys Val Tyr Ile Asn Asp Ser Val Glu Leu Ser 
    370                 375                 380                 


Gln Asn Glu Gln Lys Leu Ala Ala Trp Leu Ala Lys Arg Gly Pro Ile 
385                 390                 395                 400 


Ser Val Ala Ile Asn Ala Phe Gly Met Gln Phe Tyr Arg His Gly Ile 
                405                 410                 415     


Ser Arg Pro Leu Arg Pro Leu Cys Ser Pro Trp Leu Ile Asp His Ala 
            420                 425                 430         


Val Leu Leu Val Gly Tyr Gly Asn Arg Ser Asp Val Pro Phe Trp Ala 
        435                 440                 445             


Ile Lys Asn Ser Trp Gly Thr Asp Trp Gly Glu Lys Gly Tyr Tyr Tyr 
    450                 455                 460                 


Leu His Arg Gly Ser Gly Ala Cys Gly Val Asn Thr Met Ala Ser Ser 
465                 470                 475                 480 


Ala Val Val Asp 
                


<210>  3745
<211>  120
<212>  PRT
<213>  Homo Sapiens

<400>  3745

Met Val Cys Arg Leu Pro Val Ser Lys Lys Thr Leu Leu Cys Ser Phe 
1               5                   10                  15      


Gln Val Leu Asp Glu Leu Gly Arg His Val Leu Leu Arg Lys Asp Cys 
            20                  25                  30          


Gly Pro Val Asp Thr Lys Val Pro Gly Ala Gly Glu Pro Lys Ser Ala 
        35                  40                  45              


Phe Thr Gln Gly Ser Ala Met Ile Ser Ser Leu Ser Gln Asn His Pro 
    50                  55                  60                  


Asp Asn Arg Asn Glu Thr Phe Ser Ser Val Ile Ser Leu Leu Asn Glu 
65                  70                  75                  80  


Asp Pro Leu Ser Gln Asp Leu Pro Val Lys Met Ala Ser Ile Phe Lys 
                85                  90                  95      


Asn Phe Val Ile Thr Tyr Asn Arg Thr Tyr Glu Ser Lys Glu Glu Ala 
            100                 105                 110         


Arg Trp Arg Leu Ser Val Phe Val 
        115                 120 


<210>  3746
<211>  283
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3746

Xaa Gln Asn His Pro Asp Asn Arg Asn Glu Thr Phe Ser Ser Val Ile 
1               5                   10                  15      


Ser Leu Leu Asn Glu Asp Pro Leu Ser Gln Asp Leu Pro Val Lys Met 
            20                  25                  30          


Ala Ser Ile Phe Lys Asn Phe Val Ile Thr Tyr Asn Arg Thr Tyr Glu 
        35                  40                  45              


Ser Lys Glu Ala Arg Trp Arg Leu Ser Val Phe Val Asn Asn Met Val 
    50                  55                  60                  


Arg Ala Gln Lys Ile Gln Ala Leu Asp Arg Gly Thr Ala Gln Tyr Gly 
65                  70                  75                  80  


Val Thr Lys Phe Ser Asp Leu Thr Glu Glu Glu Phe Arg Thr Ile Tyr 
                85                  90                  95      


Leu Asn Thr Leu Leu Arg Lys Glu Pro Gly Asn Lys Met Lys Gln Ala 
            100                 105                 110         


Lys Ser Val Gly Asp Leu Ala Pro Pro Glu Trp Asp Trp Arg Ser Lys 
        115                 120                 125             


Gly Ala Val Thr Lys Val Lys Asp Gln Gly Met Cys Gly Ser Cys Trp 
    130                 135                 140                 


Ala Phe Ser Val Thr Gly Asn Val Glu Gly Gln Trp Phe Leu Asn Gln 
145                 150                 155                 160 


Gly Thr Leu Leu Ser Leu Ser Glu Gln Glu Leu Leu Asp Cys Asp Lys 
                165                 170                 175     


Met Asp Lys Ala Cys Met Gly Gly Leu Pro Ser Asn Ala Tyr Ser Ala 
            180                 185                 190         


Ile Lys Asn Leu Gly Gly Leu Glu Thr Glu Asp Asp Tyr Ser Tyr Gln 
        195                 200                 205             


Gly His Met Gln Ser Cys Asn Phe Ser Ala Glu Lys Ala Lys Val Tyr 
    210                 215                 220                 


Ile Asn Asp Ser Val Glu Leu Ser Gln Asn Glu Gln Lys Leu Ala Ala 
225                 230                 235                 240 


Trp Leu Ala Lys Arg Gly Pro Ile Ser Val Ala Ile Asn Ala Phe Gly 
                245                 250                 255     


Met Gln Phe Tyr Arg His Gly Ile Ser Arg Pro Leu Arg Pro Leu Cys 
            260                 265                 270         


Ser Pro Trp Leu Ile Asp His Ala Val Leu Leu 
        275                 280             


<210>  3747
<211>  82
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3747

Xaa Arg Thr Ile Tyr Leu Asn Thr Leu Leu Arg Lys Glu Pro Gly Asn 
1               5                   10                  15      


Lys Met Lys Gln Ala Lys Ser Val Gly Asp Leu Ala Pro Pro Glu Trp 
            20                  25                  30          


Asp Trp Arg Ser Lys Gly Ala Val Thr Lys Val Lys Asp Gln Gly Met 
        35                  40                  45              


Cys Gly Ser Cys Trp Ala Phe Ser Val Thr Gly Asn Val Glu Gly Gln 
    50                  55                  60                  


Trp Phe Leu Asn Gln Gly Thr Leu Leu Ser Leu Ser Glu Gln Ala Leu 
65                  70                  75                  80  


Gly Leu 
        


<210>  3748
<211>  255
<212>  PRT
<213>  Homo Sapiens

<400>  3748

Met Gln Pro Leu Leu Leu Leu Leu Ala Phe Leu Leu Pro Thr Gly Ala 
1               5                   10                  15      


Glu Ala Gly Glu Ile Ile Gly Gly Arg Glu Ser Arg Pro His Ser Arg 
            20                  25                  30          


Pro Tyr Met Ala Tyr Leu Gln Ile Gln Ser Pro Ala Gly Gln Ser Arg 
        35                  40                  45              


Cys Gly Gly Phe Leu Val Arg Glu Asp Phe Val Leu Thr Ala Ala His 
    50                  55                  60                  


Cys Trp Gly Ser Asn Ile Asn Val Thr Leu Gly Ala His Asn Ile Gln 
65                  70                  75                  80  


Arg Arg Glu Asn Thr Gln Gln His Ile Thr Ala Arg Arg Ala Ile Arg 
                85                  90                  95      


His Pro Gln Tyr Asn Gln Arg Thr Ile Gln Asn Asp Ile Met Leu Leu 
            100                 105                 110         


Gln Leu Ser Arg Arg Val Arg Arg Asn Arg Asn Val Asn Pro Val Ala 
        115                 120                 125             


Leu Pro Arg Ala Gln Glu Gly Leu Arg Pro Gly Thr Leu Cys Thr Val 
    130                 135                 140                 


Ala Gly Trp Gly Arg Val Ser Met Arg Arg Gly Thr Asp Thr Leu Arg 
145                 150                 155                 160 


Glu Val Gln Leu Arg Val Gln Arg Asp Arg Gln Cys Leu Arg Ile Phe 
                165                 170                 175     


Gly Ser Tyr Asp Pro Arg Arg Gln Ile Cys Val Gly Asp Arg Arg Glu 
            180                 185                 190         


Arg Lys Ala Ala Phe Lys Gly Asp Ser Gly Gly Pro Leu Leu Cys Asn 
        195                 200                 205             


Asn Val Ala His Gly Ile Val Ser Tyr Gly Lys Ser Ser Gly Val Pro 
    210                 215                 220                 


Pro Glu Val Phe Thr Arg Val Ser Ser Phe Leu Pro Trp Ile Arg Thr 
225                 230                 235                 240 


Thr Met Arg Ser Phe Lys Leu Leu Asp Gln Met Glu Thr Pro Leu 
                245                 250                 255 


<210>  3749
<211>  134
<212>  PRT
<213>  Homo Sapiens

<400>  3749

Met Ala Leu Asn Gln Phe Ser Asp Met Ser Phe Ala Glu Ile Lys His 
1               5                   10                  15      


Lys Tyr Leu Trp Ser Glu Pro Gln Asn Cys Ser Ala Thr Lys Ser Asn 
            20                  25                  30          


Tyr Leu Arg Gly Thr Gly Pro Tyr Pro Pro Ser Val Asp Trp Arg Lys 
        35                  40                  45              


Lys Gly Asn Phe Val Ser Pro Val Lys Asn Gln Gly Ala Cys Gly Ser 
    50                  55                  60                  


Cys Trp Thr Phe Ser Thr Thr Gly Ala Leu Glu Ser Ala Ile Ala Ile 
65                  70                  75                  80  


Ala Thr Gly Lys Met Leu Ser Leu Ala Glu Gln Gln Leu Val Asp Cys 
                85                  90                  95      


Ala Gln Asp Phe Asn Asn His Gly Cys Gln Gly Gly Leu Pro Ser Gln 
            100                 105                 110         


Ala Phe Glu Tyr Ile Leu Tyr Asn Lys Gly Ile Met Gly Glu Asp Thr 
        115                 120                 125             


Tyr Pro Tyr Gln Gly Lys 
    130                 


<210>  3750
<211>  323
<212>  PRT
<213>  Homo Sapiens

<400>  3750

Met Trp Ala Thr Leu Pro Leu Leu Cys Ala Ala Glu Leu Cys Val Asn 
1               5                   10                  15      


Ser Leu Glu Lys Phe His Phe Lys Ser Trp Met Ser Lys His Arg Lys 
            20                  25                  30          


Thr Tyr Ser Thr Glu Glu Tyr His His Arg Leu Gln Thr Phe Ala Ser 
        35                  40                  45              


Asn Trp Arg Lys Ile Asn Ala His Asn Asn Gly Asn His Thr Phe Lys 
    50                  55                  60                  


Met Ala Leu Asn Gln Phe Ser Asp Met Ser Phe Ala Glu Ile Lys His 
65                  70                  75                  80  


Lys Tyr Leu Trp Ser Glu Pro Gln Asn Cys Ser Ala Thr Lys Ser Asn 
                85                  90                  95      


Tyr Leu Arg Gly Thr Gly Pro Tyr Pro Pro Ser Val Asp Trp Arg Lys 
            100                 105                 110         


Lys Gly Asn Phe Val Ser Pro Val Lys Asn Gln Gly Ala Cys Gly Ser 
        115                 120                 125             


Cys Trp Thr Phe Ser Thr Thr Gly Ala Leu Glu Ser Ala Ile Ala Ile 
    130                 135                 140                 


Ala Thr Gly Lys Met Leu Ser Leu Ala Glu Gln Gln Leu Val Asp Cys 
145                 150                 155                 160 


Ala Gln Asp Phe Asn Asn His Gly Cys Gln Gly Gly Leu Pro Ser Gln 
                165                 170                 175     


Ala Phe Glu Tyr Ile Leu Tyr Asn Lys Gly Ile Met Gly Glu Asp Thr 
            180                 185                 190         


Tyr Pro Tyr Gln Gly Lys Asp Gly Tyr Cys Lys Phe Gln Pro Gly Lys 
        195                 200                 205             


Ala Ile Gly Phe Val Lys Asp Val Ala Asn Ile Thr Ile Tyr Asp Glu 
    210                 215                 220                 


Glu Ala Met Val Glu Ala Val Ala Leu Tyr Asn Pro Val Ser Phe Ala 
225                 230                 235                 240 


Phe Glu Val Thr Gln Asp Phe Met Met Tyr Arg Thr Gly Ile Tyr Ser 
                245                 250                 255     


Ser Thr Ser Cys His Lys Thr Pro Asp Lys Val Asn His Ala Val Leu 
            260                 265                 270         


Ala Val Gly Tyr Gly Glu Lys Asn Gly Ile Pro Tyr Trp Ile Val Lys 
        275                 280                 285             


Asn Ser Trp Gly Pro Gln Trp Gly Met Asn Gly Tyr Phe Leu Ile Glu 
    290                 295                 300                 


Arg Gly Lys Asn Met Cys Gly Leu Ala Ala Cys Ala Ser Tyr Pro Ile 
305                 310                 315                 320 


Pro Leu Val 
            


<210>  3751
<211>  335
<212>  PRT
<213>  Homo Sapiens

<400>  3751

Met Trp Ala Thr Leu Pro Leu Leu Cys Ala Gly Ala Trp Leu Leu Gly 
1               5                   10                  15      


Val Pro Val Cys Gly Ala Ala Glu Leu Cys Val Asn Ser Leu Glu Lys 
            20                  25                  30          


Phe His Phe Lys Ser Trp Met Ser Lys His Arg Lys Thr Tyr Ser Thr 
        35                  40                  45              


Glu Glu Tyr His His Arg Leu Gln Thr Phe Ala Ser Asn Trp Arg Lys 
    50                  55                  60                  


Ile Asn Ala His Asn Asn Gly Asn His Thr Phe Lys Met Ala Leu Asn 
65                  70                  75                  80  


Gln Phe Ser Asp Met Ser Phe Ala Glu Ile Lys His Lys Tyr Leu Trp 
                85                  90                  95      


Ser Glu Pro Gln Asn Cys Ser Ala Thr Lys Ser Asn Tyr Leu Arg Gly 
            100                 105                 110         


Thr Gly Pro Tyr Pro Pro Ser Val Asp Trp Arg Lys Lys Gly Asn Phe 
        115                 120                 125             


Val Ser Pro Val Lys Asn Gln Gly Ala Cys Gly Ser Cys Trp Thr Phe 
    130                 135                 140                 


Ser Thr Thr Gly Ala Leu Glu Ser Ala Ile Ala Ile Ala Thr Gly Lys 
145                 150                 155                 160 


Met Leu Ser Leu Ala Glu Gln Gln Leu Val Asp Cys Ala Gln Asp Phe 
                165                 170                 175     


Asn Asn His Gly Cys Gln Gly Gly Leu Pro Ser Gln Ala Phe Glu Tyr 
            180                 185                 190         


Ile Leu Tyr Asn Lys Gly Ile Met Gly Glu Asp Thr Tyr Pro Tyr Gln 
        195                 200                 205             


Gly Lys Asp Gly Tyr Cys Lys Phe Gln Pro Gly Lys Ala Ile Gly Phe 
    210                 215                 220                 


Val Lys Asp Val Ala Asn Ile Thr Ile Tyr Asp Glu Glu Ala Met Val 
225                 230                 235                 240 


Glu Ala Val Ala Leu Tyr Asn Pro Val Ser Phe Ala Phe Glu Val Thr 
                245                 250                 255     


Gln Asp Phe Met Met Tyr Arg Thr Gly Ile Tyr Ser Ser Thr Ser Cys 
            260                 265                 270         


His Lys Thr Pro Asp Lys Val Asn His Ala Val Leu Ala Val Gly Tyr 
        275                 280                 285             


Gly Glu Lys Asn Gly Ile Pro Tyr Trp Ile Val Lys Asn Ser Trp Gly 
    290                 295                 300                 


Pro Gln Trp Gly Met Asn Gly Tyr Phe Leu Ile Glu Arg Gly Lys Asn 
305                 310                 315                 320 


Met Cys Gly Leu Ala Ala Cys Ala Ser Tyr Pro Ile Pro Leu Val 
                325                 330                 335 


<210>  3752
<211>  62
<212>  PRT
<213>  Homo Sapiens

<400>  3752

Met Trp Ala Thr Leu Pro Leu Leu Cys Ala Gly Ala Trp Leu Leu Gly 
1               5                   10                  15      


Val Pro Val Cys Gly Ala Ala Glu Leu Cys Val Asn Ser Leu Glu Lys 
            20                  25                  30          


Phe His Phe Lys Ser Trp Met Ser Lys Lys Thr Lys Ala His Cys Val 
        35                  40                  45              


Leu Val Ala Glu Ser Val Gly Glu His Gln Cys Met Cys Phe 
    50                  55                  60          


<210>  3753
<211>  41
<212>  PRT
<213>  Homo Sapiens

<400>  3753

Met Trp Ala Thr Leu Pro Leu Leu Cys Ala Gly Ala Trp Leu Leu Gly 
1               5                   10                  15      


Val Pro Val Cys Gly Ala Ala Glu Leu Cys Val Asn Ser Leu Gly Thr 
            20                  25                  30          


Gln Arg Ala Arg Arg Pro Arg Gly Cys 
        35                  40      


<210>  3754
<211>  118
<212>  PRT
<213>  Homo Sapiens

<400>  3754

Met Trp Ala Thr Leu Pro Leu Leu Cys Ala Gly Ala Trp Leu Leu Gly 
1               5                   10                  15      


Val Pro Val Cys Gly Ala Ala Glu Leu Cys Val Asn Ser Leu Val Ala 
            20                  25                  30          


Gly Leu Ser Pro Pro Leu Gly Pro Trp Ser Leu Arg Ser Pro Ser Gln 
        35                  40                  45              


Pro Glu Arg Cys Cys Pro Trp Arg Asn Ser Ser Trp Trp Thr Ala Pro 
    50                  55                  60                  


Arg Thr Ser Ile Ile Thr Ala Ala Lys Gly Val Ser Pro Ala Arg Leu 
65                  70                  75                  80  


Ser Ser Ile Ser Cys Thr Thr Arg Gly Ser Trp Val Lys Thr Pro Thr 
                85                  90                  95      


Pro Thr Arg Ala Arg Met Val Ile Ala Ser Ser Asn Leu Glu Arg Pro 
            100                 105                 110         


Ser Ala Leu Ser Arg Met 
        115             


<210>  3755
<211>  258
<212>  PRT
<213>  Homo Sapiens

<400>  3755

Met His Lys Glu Asn Glu Glu Ile Tyr Asn Val Ser Glu Asn Arg Lys 
1               5                   10                  15      


His Cys Pro Ile Phe Pro Cys Pro Leu Leu Thr Arg Ser Gly Lys Val 
            20                  25                  30          


Pro Glu Phe Arg His Glu Arg Glu Glu Arg Leu Glu Glu Met Ile Arg 
        35                  40                  45              


Arg Gln Asn Leu Asp Gly Asn Leu Ser Phe Val Met Trp Gly Leu Lys 
    50                  55                  60                  


Val Leu Leu Leu Pro Val Val Ser Phe Ala Leu Tyr Pro Glu Glu Ile 
65                  70                  75                  80  


Leu Asp Thr His Trp Glu Leu Trp Lys Lys Thr His Arg Lys Gln Tyr 
                85                  90                  95      


Asn Asn Lys Val Asp Glu Ile Ser Arg Arg Leu Ile Trp Glu Lys Asn 
            100                 105                 110         


Leu Lys Tyr Ile Ser Ile His Asn Leu Glu Ala Ser Leu Gly Val His 
        115                 120                 125             


Thr Tyr Glu Leu Ala Met Asn His Leu Gly Asp Met Thr Ser Glu Glu 
    130                 135                 140                 


Val Val Gln Lys Met Thr Gly Leu Lys Val Pro Leu Ser His Ser Arg 
145                 150                 155                 160 


Ser Asn Asp Thr Leu Tyr Ile Pro Glu Trp Glu Gly Arg Ala Pro Asp 
                165                 170                 175     


Ser Val Asp Tyr Arg Lys Lys Gly Tyr Val Thr Pro Val Lys Asn Gln 
            180                 185                 190         


Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ser Val Gly Ala Leu Glu 
        195                 200                 205             


Gly Gln Leu Lys Lys Lys Thr Gly Lys Leu Leu Asn Leu Ser Pro Gln 
    210                 215                 220                 


Asn Leu Val Asp Cys Val Ser Glu Asn Asp Gly Cys Gly Gly Gly Tyr 
225                 230                 235                 240 


Met Thr Asn Ala Phe Gln Tyr Val Gln Lys Asn Arg Gly Ile Asp Ser 
                245                 250                 255     


Glu Asp 
        


<210>  3756
<211>  329
<212>  PRT
<213>  Homo Sapiens

<400>  3756

Met Trp Gly Leu Lys Val Leu Leu Leu Pro Val Val Ser Phe Ala Leu 
1               5                   10                  15      


Tyr Pro Glu Glu Ile Leu Asp Thr His Trp Glu Leu Trp Lys Lys Thr 
            20                  25                  30          


His Arg Lys Gln Tyr Asn Asn Lys Val Asp Glu Ile Ser Arg Arg Leu 
        35                  40                  45              


Ile Trp Glu Lys Asn Leu Lys Tyr Ile Ser Ile His Asn Leu Glu Ala 
    50                  55                  60                  


Ser Leu Gly Val His Thr Tyr Glu Leu Ala Met Asn His Leu Gly Asp 
65                  70                  75                  80  


Met Thr Ser Glu Glu Val Val Gln Lys Met Thr Gly Leu Lys Val Pro 
                85                  90                  95      


Leu Ser His Ser Arg Ser Asn Asp Thr Leu Tyr Ile Pro Glu Trp Glu 
            100                 105                 110         


Gly Arg Ala Pro Asp Ser Val Asp Tyr Arg Lys Lys Gly Tyr Val Thr 
        115                 120                 125             


Pro Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ser 
    130                 135                 140                 


Val Gly Ala Leu Glu Gly Gln Leu Lys Lys Lys Thr Gly Lys Leu Leu 
145                 150                 155                 160 


Asn Leu Ser Pro Gln Asn Leu Val Asp Cys Val Ser Glu Asn Asp Gly 
                165                 170                 175     


Cys Gly Gly Gly Tyr Met Thr Asn Ala Phe Gln Tyr Val Gln Lys Asn 
            180                 185                 190         


Arg Gly Ile Asp Ser Glu Asp Ala Tyr Pro Tyr Val Gly Gln Glu Glu 
        195                 200                 205             


Ser Cys Met Tyr Asn Pro Thr Gly Lys Ala Ala Lys Cys Arg Gly Tyr 
    210                 215                 220                 


Arg Glu Ile Pro Glu Gly Asn Glu Lys Ala Leu Lys Arg Ala Val Ala 
225                 230                 235                 240 


Arg Val Gly Pro Val Ser Val Ala Ile Asp Ala Ser Leu Thr Ser Phe 
                245                 250                 255     


Gln Phe Tyr Ser Lys Gly Val Tyr Tyr Asp Glu Ser Cys Asn Ser Asp 
            260                 265                 270         


Asn Leu Asn His Ala Val Leu Ala Val Gly Tyr Gly Ile Gln Lys Gly 
        275                 280                 285             


Asn Lys His Trp Ile Ile Lys Asn Ser Trp Gly Glu Asn Trp Gly Asn 
    290                 295                 300                 


Lys Gly Tyr Ile Leu Met Ala Arg Asn Lys Asn Asn Ala Cys Gly Ile 
305                 310                 315                 320 


Ala Asn Leu Ala Ser Phe Pro Lys Met 
                325                 


<210>  3757
<211>  333
<212>  PRT
<213>  Homo Sapiens

<400>  3757

Met Asn Pro Thr Leu Ile Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser 
1               5                   10                  15      


Ala Thr Leu Thr Phe Asp His Ser Leu Glu Ala Gln Trp Thr Lys Trp 
            20                  25                  30          


Lys Ala Met His Asn Arg Leu Tyr Gly Met Asn Glu Glu Gly Trp Arg 
        35                  40                  45              


Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gln 
    50                  55                  60                  


Glu Tyr Arg Glu Gly Lys His Ser Phe Thr Met Ala Met Asn Ala Phe 
65                  70                  75                  80  


Gly Asp Met Thr Ser Glu Glu Phe Arg Gln Val Met Asn Gly Phe Gln 
                85                  90                  95      


Asn Arg Lys Pro Arg Lys Gly Lys Val Phe Gln Glu Pro Leu Phe Tyr 
            100                 105                 110         


Glu Ala Pro Arg Ser Val Asp Trp Arg Glu Lys Gly Tyr Val Thr Pro 
        115                 120                 125             


Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr 
    130                 135                 140                 


Gly Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Arg Leu Ile Ser 
145                 150                 155                 160 


Leu Ser Glu Gln Asn Leu Val Asp Cys Ser Gly Pro Gln Gly Asn Glu 
                165                 170                 175     


Gly Cys Asn Gly Gly Leu Met Asp Tyr Ala Phe Gln Tyr Val Gln Asp 
            180                 185                 190         


Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala Thr Glu 
        195                 200                 205             


Glu Ser Cys Lys Tyr Asn Pro Lys Tyr Ser Val Ala Asn Asp Thr Gly 
    210                 215                 220                 


Phe Val Asp Ile Pro Lys Gln Glu Lys Ala Leu Met Lys Ala Val Ala 
225                 230                 235                 240 


Thr Val Gly Pro Ile Ser Val Ala Ile Asp Ala Gly His Glu Ser Phe 
                245                 250                 255     


Leu Phe Tyr Lys Glu Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser Glu 
            260                 265                 270         


Asp Met Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Ser Thr 
        275                 280                 285             


Glu Ser Asp Asn Asn Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly Glu 
    290                 295                 300                 


Glu Trp Gly Met Gly Gly Tyr Val Lys Met Ala Lys Asp Arg Arg Asn 
305                 310                 315                 320 


His Cys Gly Ile Ala Ser Ala Ala Ser Tyr Pro Thr Val 
                325                 330             


<210>  3758
<211>  333
<212>  PRT
<213>  Homo Sapiens

<400>  3758

Met Asn Pro Thr Leu Ile Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser 
1               5                   10                  15      


Ala Thr Leu Thr Phe Asp His Ser Leu Glu Ala Gln Trp Thr Lys Trp 
            20                  25                  30          


Lys Ala Met His Asn Arg Leu Tyr Gly Met Asn Glu Glu Gly Trp Arg 
        35                  40                  45              


Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gln 
    50                  55                  60                  


Glu Tyr Arg Glu Gly Lys His Ser Phe Thr Met Ala Met Asn Ala Phe 
65                  70                  75                  80  


Gly Asp Met Thr Ser Glu Glu Phe Arg Gln Val Met Asn Gly Phe Gln 
                85                  90                  95      


Asn Arg Lys Pro Arg Lys Gly Lys Val Phe Gln Glu Pro Leu Phe Tyr 
            100                 105                 110         


Glu Ala Pro Arg Ser Val Asp Trp Arg Glu Lys Gly Tyr Val Thr Pro 
        115                 120                 125             


Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr 
    130                 135                 140                 


Gly Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Arg Leu Ile Ser 
145                 150                 155                 160 


Leu Ser Glu Gln Asn Leu Val Asp Cys Ser Gly Pro Gln Gly Asn Glu 
                165                 170                 175     


Gly Cys Asn Gly Gly Leu Met Asp Tyr Ala Phe Gln Tyr Val Gln Asp 
            180                 185                 190         


Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala Thr Glu 
        195                 200                 205             


Glu Ser Cys Lys Tyr Asn Pro Lys Tyr Ser Val Ala Asn Asp Thr Gly 
    210                 215                 220                 


Phe Val Asp Ile Pro Lys Gln Glu Lys Ala Leu Met Lys Ala Val Ala 
225                 230                 235                 240 


Thr Val Gly Pro Ile Ser Val Ala Ile Asp Ala Gly His Glu Ser Phe 
                245                 250                 255     


Leu Phe Tyr Lys Glu Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser Glu 
            260                 265                 270         


Asp Met Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Ser Thr 
        275                 280                 285             


Glu Ser Asp Asn Asn Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly Glu 
    290                 295                 300                 


Glu Trp Gly Met Gly Gly Tyr Val Lys Met Ala Lys Asp Arg Arg Asn 
305                 310                 315                 320 


His Cys Gly Ile Ala Ser Ala Ala Ser Tyr Pro Thr Val 
                325                 330             


<210>  3759
<211>  225
<212>  PRT
<213>  Homo Sapiens

<400>  3759

Met Asn Pro Thr Leu Ile Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser 
1               5                   10                  15      


Ala Thr Leu Thr Phe Asp His Ser Leu Glu Ala Gln Trp Thr Lys Trp 
            20                  25                  30          


Lys Ala Met His Asn Arg Leu Tyr Gly Met Asn Glu Glu Gly Trp Arg 
        35                  40                  45              


Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gln 
    50                  55                  60                  


Glu Tyr Arg Glu Gly Lys His Ser Phe Thr Met Ala Met Asn Ala Phe 
65                  70                  75                  80  


Gly Asp Met Thr Ser Glu Glu Phe Arg Gln Val Met Asn Gly Phe Gln 
                85                  90                  95      


Asn Arg Lys Pro Arg Lys Gly Lys Val Phe Gln Glu Pro Leu Phe Tyr 
            100                 105                 110         


Glu Ala Pro Arg Ser Val Asp Trp Arg Glu Lys Gly Tyr Val Thr Pro 
        115                 120                 125             


Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr 
    130                 135                 140                 


Gly Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Arg Leu Ile Ser 
145                 150                 155                 160 


Leu Ser Glu Gln Asn Leu Val Asp Cys Ser Gly Pro Gln Gly Asn Glu 
                165                 170                 175     


Gly Cys Asn Gly Gly Leu Met Asp Tyr Ala Phe Gln Tyr Val Gln Asp 
            180                 185                 190         


Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala Thr Val 
        195                 200                 205             


Ser Gly Ala Pro Cys His His Ser Ser Ser Ala Phe Gly Arg Trp Thr 
    210                 215                 220                 


Leu 
225 


<210>  3760
<211>  321
<212>  PRT
<213>  Homo Sapiens

<400>  3760

Met Asp Val Arg Ala Leu Pro Trp Leu Pro Trp Leu Leu Trp Leu Leu 
1               5                   10                  15      


Cys Arg Gly Gly Gly Asp Ala Asp Ser Arg Ala Pro Phe Thr Pro Thr 
            20                  25                  30          


Trp Pro Arg Ser Arg Glu Arg Glu Ala Ala Ala Phe Arg Glu Ser Leu 
        35                  40                  45              


Asn Arg His Arg Tyr Leu Asn Ser Leu Phe Pro Ser Glu Asn Ser Thr 
    50                  55                  60                  


Ala Phe Tyr Gly Ile Asn Gln Phe Ser Tyr Leu Phe Pro Glu Glu Phe 
65                  70                  75                  80  


Lys Ala Ile Tyr Leu Arg Ser Lys Pro Ser Lys Phe Pro Arg Tyr Ser 
                85                  90                  95      


Ala Glu Val His Met Ser Ile Pro Asn Val Ser Leu Pro Leu Arg Phe 
            100                 105                 110         


Asp Trp Arg Asp Lys Gln Val Val Thr Gln Val Arg Asn Gln Gln Met 
        115                 120                 125             


Cys Gly Gly Cys Trp Ala Phe Ser Val Val Gly Ala Val Glu Ser Ala 
    130                 135                 140                 


Tyr Ala Ile Lys Gly Lys Pro Leu Glu Asp Leu Ser Val Gln Gln Val 
145                 150                 155                 160 


Ile Asp Cys Ser Tyr Asn Asn Tyr Gly Cys Asn Gly Gly Ser Thr Leu 
                165                 170                 175     


Asn Ala Leu Asn Trp Leu Asn Lys Met Gln Val Lys Leu Val Lys Asp 
            180                 185                 190         


Ser Glu Tyr Pro Phe Lys Ala Gln Asn Gly Leu Cys His Tyr Phe Ser 
        195                 200                 205             


Gly Ser His Ser Gly Phe Ser Ile Lys Gly Tyr Ser Ala Tyr Asp Phe 
    210                 215                 220                 


Ser Asp Gln Glu Asp Glu Met Ala Lys Ala Leu Leu Thr Phe Gly Pro 
225                 230                 235                 240 


Leu Val Val Ile Val Asp Ala Val Ser Trp Gln Asp Tyr Leu Gly Gly 
                245                 250                 255     


Ile Ile Gln His His Cys Ser Ser Gly Glu Ala Asn His Ala Val Leu 
            260                 265                 270         


Ile Thr Gly Phe Asp Lys Thr Gly Ser Thr Pro Tyr Trp Ile Val Arg 
        275                 280                 285             


Asn Ser Trp Gly Ser Ser Trp Gly Val Asp Gly Tyr Ala His Val Lys 
    290                 295                 300                 


Met Gly Ser Asn Val Cys Gly Ile Ala Asp Ser Val Ser Ser Ile Phe 
305                 310                 315                 320 


Val 
    


<210>  3761
<211>  117
<212>  PRT
<213>  Homo Sapiens

<400>  3761

Ile Ile Asp Asn Lys Gly Ile Asp Ser Asp Ala Ser Tyr Pro Tyr Lys 
1               5                   10                  15      


Ala Met Asp Gln Lys Cys Gln Tyr Asp Ser Lys Tyr Arg Ala Ala Thr 
            20                  25                  30          


Cys Ser Lys Tyr Thr Glu Leu Pro Tyr Gly Arg Glu Asp Val Leu Lys 
        35                  40                  45              


Glu Ala Val Ala Asn Lys Gly Pro Val Ser Val Gly Val Asp Ala Arg 
    50                  55                  60                  


His Pro Ser Phe Phe Leu Tyr Arg Ser Asp Gly Val Leu Leu Cys Cys 
65                  70                  75                  80  


Gln Ala Gly Val Arg Trp His Asp Leu Ser Ser Leu Gln Pro Leu Pro 
                85                  90                  95      


Pro Gly Phe Lys Gln Phe Ser Cys Leu Ser Leu Leu Ser Ser Trp Asp 
            100                 105                 110         


Tyr Arg Cys Leu Leu 
        115         


<210>  3762
<211>  281
<212>  PRT
<213>  Homo Sapiens

<400>  3762

Met Lys Arg Leu Val Cys Val Leu Leu Val Cys Ser Ser Ala Val Ala 
1               5                   10                  15      


Gln Leu His Lys Asp Pro Thr Leu Asp His His Trp His Leu Trp Lys 
            20                  25                  30          


Lys Thr Tyr Gly Lys Gln Tyr Lys Glu Lys Asn Glu Glu Ala Val Arg 
        35                  40                  45              


Arg Leu Ile Trp Glu Lys Asn Leu Lys Phe Val Met Leu His Asn Leu 
    50                  55                  60                  


Glu His Ser Met Gly Met His Ser Tyr Asp Leu Gly Met Asn His Leu 
65                  70                  75                  80  


Gly Asp Met Gly Ser Cys Gly Ala Cys Trp Ala Phe Ser Ala Val Gly 
                85                  90                  95      


Ala Leu Glu Ala Gln Leu Lys Leu Lys Thr Gly Lys Leu Val Ser Leu 
            100                 105                 110         


Ser Ala Gln Asn Leu Val Asp Cys Ser Thr Glu Lys Tyr Gly Asn Lys 
        115                 120                 125             


Gly Cys Asn Gly Gly Phe Met Thr Thr Ala Phe Gln Tyr Ile Ile Asp 
    130                 135                 140                 


Asn Lys Gly Ile Asp Ser Asp Ala Ser Tyr Pro Tyr Lys Ala Met Asp 
145                 150                 155                 160 


Gln Lys Cys Gln Tyr Asp Ser Lys Tyr Arg Ala Ala Thr Cys Ser Lys 
                165                 170                 175     


Tyr Thr Glu Leu Pro Tyr Gly Arg Glu Asp Val Leu Lys Glu Ala Val 
            180                 185                 190         


Ala Asn Lys Gly Pro Val Ser Val Gly Val Asp Ala Arg His Pro Ser 
        195                 200                 205             


Phe Phe Leu Tyr Arg Ser Gly Val Tyr Tyr Glu Pro Ser Cys Thr Gln 
    210                 215                 220                 


Asn Val Asn His Gly Val Leu Val Val Gly Tyr Gly Asp Leu Asn Gly 
225                 230                 235                 240 


Lys Glu Tyr Trp Leu Val Lys Asn Ser Trp Gly His Asn Phe Gly Glu 
                245                 250                 255     


Glu Gly Tyr Ile Arg Met Ala Arg Asn Lys Gly Asn His Cys Gly Ile 
            260                 265                 270         


Ala Ser Phe Pro Ser Tyr Pro Glu Ile 
        275                 280     


<210>  3763
<211>  331
<212>  PRT
<213>  Homo Sapiens

<400>  3763

Met Lys Arg Leu Val Cys Val Leu Leu Val Cys Ser Ser Ala Val Ala 
1               5                   10                  15      


Gln Leu His Lys Asp Pro Thr Leu Asp His His Trp His Leu Trp Lys 
            20                  25                  30          


Lys Thr Tyr Gly Lys Gln Tyr Lys Glu Lys Asn Glu Glu Ala Val Arg 
        35                  40                  45              


Arg Leu Ile Trp Glu Lys Asn Leu Lys Phe Val Met Leu His Asn Leu 
    50                  55                  60                  


Glu His Ser Met Gly Met His Ser Tyr Asp Leu Gly Met Asn His Leu 
65                  70                  75                  80  


Gly Asp Met Thr Ser Glu Glu Val Met Ser Leu Met Ser Ser Leu Arg 
                85                  90                  95      


Val Pro Ser Gln Trp Gln Arg Asn Ile Thr Tyr Lys Ser Asn Pro Asn 
            100                 105                 110         


Arg Ile Leu Pro Asp Ser Val Asp Trp Arg Glu Lys Gly Cys Val Thr 
        115                 120                 125             


Glu Val Lys Tyr Gln Gly Ser Cys Gly Ala Cys Trp Ala Phe Ser Ala 
    130                 135                 140                 


Val Gly Ala Leu Glu Ala Gln Leu Lys Leu Lys Thr Gly Lys Leu Val 
145                 150                 155                 160 


Ser Leu Ser Ala Gln Asn Leu Val Asp Cys Ser Thr Glu Lys Tyr Gly 
                165                 170                 175     


Asn Lys Gly Cys Asn Gly Gly Phe Met Thr Thr Ala Phe Gln Tyr Ile 
            180                 185                 190         


Ile Asp Asn Lys Gly Ile Asp Ser Asp Ala Ser Tyr Pro Tyr Lys Ala 
        195                 200                 205             


Met Asp Gln Lys Cys Gln Tyr Asp Ser Lys Tyr Arg Ala Ala Thr Cys 
    210                 215                 220                 


Ser Lys Tyr Thr Glu Leu Pro Tyr Gly Arg Glu Asp Val Leu Lys Glu 
225                 230                 235                 240 


Ala Val Ala Asn Lys Gly Pro Val Ser Val Gly Val Asp Ala Arg His 
                245                 250                 255     


Pro Ser Phe Phe Leu Tyr Arg Ser Gly Val Tyr Tyr Glu Pro Ser Cys 
            260                 265                 270         


Thr Gln Asn Val Asn His Gly Val Leu Val Val Gly Tyr Gly Asp Leu 
        275                 280                 285             


Asn Gly Lys Glu Tyr Trp Leu Val Lys Asn Ser Trp Gly His Asn Phe 
    290                 295                 300                 


Gly Glu Glu Gly Tyr Ile Arg Met Ala Arg Asn Lys Gly Asn His Cys 
305                 310                 315                 320 


Gly Ile Ala Ser Phe Pro Ser Tyr Pro Glu Ile 
                325                 330     


<210>  3764
<211>  96
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3764

Xaa Val Leu Lys Glu Ala Val Ala Asn Lys Gly Pro Val Ser Val Gly 
1               5                   10                  15      


Val Asp Ala Arg His Pro Ser Phe Phe Leu Tyr Arg Ser Gly Val Tyr 
            20                  25                  30          


Tyr Glu Pro Ser Cys Thr Gln Asn Val Asn His Gly Val Leu Val Val 
        35                  40                  45              


Gly Tyr Gly Asp Leu Asn Gly Lys Glu Tyr Trp Leu Val Lys Asn Ser 
    50                  55                  60                  


Trp Gly His Asn Phe Gly Glu Glu Gly Tyr Ile Arg Met Ala Arg Asn 
65                  70                  75                  80  


Lys Gly Asn His Cys Gly Ile Ala Ser Phe Pro Ser Tyr Pro Glu Ile 
                85                  90                  95      


<210>  3765
<211>  5
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3765

Xaa Tyr Pro Glu Ile 
1               5   


<210>  3766
<211>  334
<212>  PRT
<213>  Homo Sapiens

<400>  3766

Met Asn Leu Ser Leu Val Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser 
1               5                   10                  15      


Ala Val Pro Lys Phe Asp Gln Asn Leu Asp Thr Lys Trp Tyr Gln Trp 
            20                  25                  30          


Lys Ala Thr His Arg Arg Leu Tyr Gly Ala Asn Glu Glu Gly Trp Arg 
        35                  40                  45              


Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gly 
    50                  55                  60                  


Glu Tyr Ser Gln Gly Lys His Gly Phe Thr Met Ala Met Asn Ala Phe 
65                  70                  75                  80  


Gly Asp Met Thr Asn Glu Glu Phe Arg Gln Met Met Gly Cys Phe Arg 
                85                  90                  95      


Asn Gln Lys Phe Arg Lys Gly Lys Val Phe Arg Glu Pro Leu Phe Leu 
            100                 105                 110         


Asp Leu Pro Lys Ser Val Asp Trp Arg Lys Lys Gly Tyr Val Thr Pro 
        115                 120                 125             


Val Lys Asn Gln Lys Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr 
    130                 135                 140                 


Gly Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Lys Leu Val Ser 
145                 150                 155                 160 


Leu Ser Glu Gln Asn Leu Val Asp Cys Ser Arg Pro Gln Gly Asn Gln 
                165                 170                 175     


Gly Cys Asn Gly Gly Phe Met Ala Arg Ala Phe Gln Tyr Val Lys Glu 
            180                 185                 190         


Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Val Ala Val Asp 
        195                 200                 205             


Glu Ile Cys Lys Tyr Arg Pro Glu Asn Ser Val Ala Asn Asp Thr Gly 
    210                 215                 220                 


Phe Thr Val Val Ala Pro Gly Lys Glu Lys Ala Leu Met Lys Ala Val 
225                 230                 235                 240 


Ala Thr Val Gly Pro Ile Ser Val Ala Met Asp Ala Gly His Ser Ser 
                245                 250                 255     


Phe Gln Phe Tyr Lys Ser Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser 
            260                 265                 270         


Lys Asn Leu Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Gly 
        275                 280                 285             


Ala Asn Ser Asn Asn Ser Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly 
    290                 295                 300                 


Pro Glu Trp Gly Ser Asn Gly Tyr Val Lys Ile Ala Lys Asp Lys Asn 
305                 310                 315                 320 


Asn His Cys Gly Ile Ala Thr Ala Ala Ser Tyr Pro Asn Val 
                325                 330                 


<210>  3767
<211>  334
<212>  PRT
<213>  Homo Sapiens

<400>  3767

Met Asn Leu Ser Leu Val Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser 
1               5                   10                  15      


Ala Val Pro Lys Phe Asp Gln Asn Leu Asp Thr Lys Trp Tyr Gln Trp 
            20                  25                  30          


Lys Ala Thr His Arg Arg Leu Tyr Gly Ala Asn Glu Glu Gly Trp Arg 
        35                  40                  45              


Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gly 
    50                  55                  60                  


Glu Tyr Ser Gln Gly Lys His Gly Phe Thr Met Ala Met Asn Ala Phe 
65                  70                  75                  80  


Gly Asp Met Thr Asn Glu Glu Phe Arg Gln Met Met Gly Cys Phe Arg 
                85                  90                  95      


Asn Gln Lys Phe Arg Lys Gly Lys Val Phe Arg Glu Pro Leu Phe Leu 
            100                 105                 110         


Asp Leu Pro Lys Ser Val Asp Trp Arg Lys Lys Gly Tyr Val Thr Pro 
        115                 120                 125             


Val Lys Asn Gln Lys Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr 
    130                 135                 140                 


Gly Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Lys Leu Val Ser 
145                 150                 155                 160 


Leu Ser Glu Gln Asn Leu Val Asp Cys Ser Arg Pro Gln Gly Asn Gln 
                165                 170                 175     


Gly Cys Asn Gly Gly Phe Met Ala Arg Ala Phe Gln Tyr Val Lys Glu 
            180                 185                 190         


Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Val Ala Val Asp 
        195                 200                 205             


Glu Ile Cys Lys Tyr Arg Pro Glu Asn Ser Val Ala Asn Asp Thr Gly 
    210                 215                 220                 


Phe Thr Val Val Ala Pro Gly Lys Glu Lys Ala Leu Met Lys Ala Val 
225                 230                 235                 240 


Ala Thr Val Gly Pro Ile Ser Val Ala Met Asp Ala Gly His Ser Ser 
                245                 250                 255     


Phe Gln Phe Tyr Lys Ser Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser 
            260                 265                 270         


Lys Asn Leu Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Gly 
        275                 280                 285             


Ala Asn Ser Asn Asn Ser Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly 
    290                 295                 300                 


Pro Glu Trp Gly Ser Asn Gly Tyr Val Lys Ile Ala Lys Asp Lys Asn 
305                 310                 315                 320 


Asn His Cys Gly Ile Ala Thr Ala Ala Ser Tyr Pro Asn Val 
                325                 330                 


<210>  3768
<211>  211
<212>  PRT
<213>  Homo Sapiens

<400>  3768

Ala Leu Thr Ala His Pro Ser Cys Leu Leu Ala Leu Leu Val Ala Gly 
1               5                   10                  15      


Leu Ala Gln Gly Ile Arg Gly Pro Leu Arg Ala Gln Asp Leu Gly Pro 
            20                  25                  30          


Gln Pro Leu Glu Leu Lys Glu Ala Phe Lys Leu Phe Gln Ile Gln Phe 
        35                  40                  45              


Asn Arg Ser Tyr Leu Ser Pro Glu Glu His Ala His Arg Leu Asp Ile 
    50                  55                  60                  


Phe Ala His Asn Leu Ala Gln Ala Gln Arg Leu Gln Glu Glu Asp Leu 
65                  70                  75                  80  


Gly Thr Ala Glu Phe Gly Val Thr Pro Phe Ser Asp Leu Thr Glu Glu 
                85                  90                  95      


Glu Phe Gly Gln Leu Tyr Gly Tyr Arg Arg Ala Ala Gly Gly Val Pro 
            100                 105                 110         


Ser Met Gly Arg Glu Ile Arg Ser Glu Glu Pro Glu Glu Ser Val Pro 
        115                 120                 125             


Phe Ser Cys Asp Trp Arg Lys Val Ala Ser Ala Ile Ser Pro Ile Lys 
    130                 135                 140                 


Asp Gln Lys Asn Cys Asn Cys Cys Trp Ala Met Ala Ala Ala Gly Asn 
145                 150                 155                 160 


Ile Glu Thr Leu Trp Arg Ile Ser Phe Trp Asp Phe Val Asp Val Ser 
                165                 170                 175     


Val Gln Gly Gly Leu Ala Ser Glu Lys Asp Tyr Pro Phe Gln Gly Lys 
            180                 185                 190         


Val Arg Ala His Arg Cys His Pro Lys Lys Tyr Gln Lys Val Ala Trp 
        195                 200                 205             


Ile Gln Asp 
    210     


<210>  3769
<211>  376
<212>  PRT
<213>  Homo Sapiens

<400>  3769

Met Ala Leu Thr Ala His Pro Ser Cys Leu Leu Ala Leu Leu Val Ala 
1               5                   10                  15      


Gly Leu Ala Gln Gly Ile Arg Gly Pro Leu Arg Ala Gln Asp Leu Gly 
            20                  25                  30          


Pro Gln Pro Leu Glu Leu Lys Glu Ala Phe Lys Leu Phe Gln Ile Gln 
        35                  40                  45              


Phe Asn Arg Ser Tyr Leu Ser Pro Glu Glu His Ala His Arg Leu Asp 
    50                  55                  60                  


Ile Phe Ala His Asn Leu Ala Gln Ala Gln Arg Leu Gln Glu Glu Asp 
65                  70                  75                  80  


Leu Gly Thr Ala Glu Phe Gly Val Thr Pro Phe Ser Asp Leu Thr Glu 
                85                  90                  95      


Glu Glu Phe Gly Gln Leu Tyr Gly Tyr Arg Arg Ala Ala Gly Gly Val 
            100                 105                 110         


Pro Ser Met Gly Arg Glu Ile Arg Ser Glu Glu Pro Glu Glu Ser Val 
        115                 120                 125             


Pro Phe Ser Cys Asp Trp Arg Lys Val Ala Ser Ala Ile Ser Pro Ile 
    130                 135                 140                 


Lys Asp Gln Lys Asn Cys Asn Cys Cys Trp Ala Met Ala Ala Ala Gly 
145                 150                 155                 160 


Asn Ile Glu Thr Leu Trp Arg Ile Ser Phe Trp Asp Phe Val Asp Val 
                165                 170                 175     


Ser Val Gln Glu Leu Leu Asp Cys Gly Arg Cys Gly Asp Gly Cys His 
            180                 185                 190         


Gly Gly Phe Val Trp Asp Ala Phe Ile Thr Val Leu Asn Asn Ser Gly 
        195                 200                 205             


Leu Ala Ser Glu Lys Asp Tyr Pro Phe Gln Gly Lys Val Arg Ala His 
    210                 215                 220                 


Arg Cys His Pro Lys Lys Tyr Gln Lys Val Ala Trp Ile Gln Asp Phe 
225                 230                 235                 240 


Ile Met Leu Gln Asn Asn Glu His Arg Ile Ala Gln Tyr Leu Ala Thr 
                245                 250                 255     


Tyr Gly Pro Ile Thr Val Thr Ile Asn Met Lys Pro Leu Gln Leu Tyr 
            260                 265                 270         


Arg Lys Gly Val Ile Lys Ala Thr Pro Thr Thr Cys Asp Pro Gln Leu 
        275                 280                 285             


Val Asp His Ser Val Leu Leu Val Gly Phe Gly Ser Val Lys Ser Glu 
    290                 295                 300                 


Glu Gly Ile Trp Ala Glu Thr Val Ser Ser Gln Ser Gln Pro Gln Pro 
305                 310                 315                 320 


Pro His Pro Thr Pro Tyr Trp Ile Leu Lys Asn Ser Trp Gly Ala Gln 
                325                 330                 335     


Trp Gly Glu Lys Gly Tyr Phe Arg Leu His Arg Gly Ser Asn Thr Cys 
            340                 345                 350         


Gly Ile Thr Lys Phe Pro Leu Thr Ala Arg Val Gln Lys Pro Asp Met 
        355                 360                 365             


Lys Pro Arg Val Ser Cys Pro Pro 
    370                 375     


<210>  3770
<211>  364
<212>  PRT
<213>  Homo Sapiens

<400>  3770

Met Ala Leu Thr Ala His Pro Ser Cys Leu Leu Ala Leu Leu Val Ala 
1               5                   10                  15      


Gly Leu Ala Gln Gly Ile Arg Gly Pro Leu Arg Ala Gln Asp Leu Gly 
            20                  25                  30          


Pro Gln Pro Leu Glu Leu Lys Glu Ala Phe Lys Leu Phe Gln Ile Gln 
        35                  40                  45              


Phe Asn Arg Ser Tyr Leu Ser Pro Glu Glu His Ala His Arg Leu Asp 
    50                  55                  60                  


Ile Phe Ala His Asn Leu Ala Gln Ala Gln Arg Leu Gln Glu Glu Asp 
65                  70                  75                  80  


Leu Gly Thr Ala Glu Phe Gly Val Thr Pro Phe Ser Asp Leu Thr Glu 
                85                  90                  95      


Glu Glu Phe Gly Gln Leu Tyr Gly Tyr Arg Arg Ala Ala Gly Gly Val 
            100                 105                 110         


Pro Ser Met Gly Arg Glu Ile Arg Ser Glu Glu Pro Glu Glu Ser Val 
        115                 120                 125             


Pro Phe Ser Cys Asp Trp Arg Lys Val Ala Ser Ala Ile Ser Pro Ile 
    130                 135                 140                 


Lys Asp Gln Lys Asn Cys Asn Cys Cys Trp Ala Met Ala Ala Ala Gly 
145                 150                 155                 160 


Asn Ile Glu Thr Leu Trp Arg Ile Ser Phe Trp Asp Phe Val Asp Val 
                165                 170                 175     


Ser Val Gln Glu Leu Leu Asp Cys Gly Arg Cys Gly Asp Gly Cys His 
            180                 185                 190         


Gly Gly Phe Val Trp Asp Ala Phe Ile Thr Val Leu Asn Asn Ser Gly 
        195                 200                 205             


Leu Ala Ser Glu Lys Asp Tyr Pro Phe Gln Gly Lys Val Arg Ala His 
    210                 215                 220                 


Arg Cys His Pro Lys Lys Tyr Gln Lys Val Ala Trp Ile Gln Asp Phe 
225                 230                 235                 240 


Ile Met Leu Gln Asn Asn Glu His Arg Ile Ala Gln Tyr Leu Ala Thr 
                245                 250                 255     


Tyr Gly Pro Ile Thr Val Thr Ile Asn Met Lys Pro Leu Gln Leu Tyr 
            260                 265                 270         


Arg Lys Gly Val Ile Lys Ala Thr Pro Thr Thr Cys Asp Pro Gln Leu 
        275                 280                 285             


Val Asp His Ser Val Leu Leu Val Gly Phe Gly Ser Val Lys Ser Glu 
    290                 295                 300                 


Glu Gly Ile Trp Ala Glu Thr Val Ser Ser Gln Ser Gln Pro Gln Pro 
305                 310                 315                 320 


Pro His Pro Thr Pro Tyr Trp Ile Leu Lys Asn Ser Trp Gly Ala Gln 
                325                 330                 335     


Trp Gly Glu Lys Val Ser Val Ile Tyr Trp Gly Arg Gly Gln Gly Arg 
            340                 345                 350         


Thr Gly Leu Phe Pro Pro Ser Arg Pro Tyr Val Pro 
        355                 360                 


<210>  3771
<211>  303
<212>  PRT
<213>  Homo Sapiens

<400>  3771

Met Ala Arg Arg Gly Pro Gly Trp Arg Pro Leu Leu Leu Leu Val Leu 
1               5                   10                  15      


Leu Ala Gly Ala Ala Gln Gly Gly Leu Tyr Phe Arg Arg Gly Gln Thr 
            20                  25                  30          


Cys Tyr Arg Pro Leu Arg Gly Asp Gly Leu Ala Pro Leu Gly Arg Ser 
        35                  40                  45              


Thr Tyr Pro Arg Pro His Glu Tyr Leu Ser Pro Ala Asp Leu Pro Lys 
    50                  55                  60                  


Ser Trp Asp Trp Arg Asn Val Asp Gly Val Asn Tyr Ala Ser Ile Thr 
65                  70                  75                  80  


Arg Asn Gln His Ile Pro Gln Tyr Cys Gly Ser Cys Trp Ala His Ala 
                85                  90                  95      


Ser Thr Ser Ala Met Ala Asp Arg Ile Asn Ile Lys Arg Lys Gly Ala 
            100                 105                 110         


Trp Pro Ser Thr Leu Leu Ser Val Gln Asn Val Ile Asp Cys Gly Asn 
        115                 120                 125             


Ala Gly Ser Cys Glu Gly Gly Asn Asp Leu Ser Val Trp Asp Tyr Ala 
    130                 135                 140                 


His Gln His Gly Ile Pro Asp Glu Thr Cys Asn Asn Tyr Gln Ala Lys 
145                 150                 155                 160 


Asp Gln Glu Cys Asp Lys Phe Asn Gln Cys Gly Thr Cys Asn Glu Phe 
                165                 170                 175     


Lys Glu Cys His Ala Ile Arg Asn Tyr Thr Leu Trp Arg Val Gly Asp 
            180                 185                 190         


Tyr Gly Ser Leu Ser Gly Arg Glu Lys Met Met Ala Glu Ile Tyr Ala 
        195                 200                 205             


Asn Gly Pro Ile Ser Cys Gly Ile Met Ala Thr Glu Arg Leu Ala Asn 
    210                 215                 220                 


Tyr Thr Gly Gly Ile Tyr Ala Glu Tyr Gln Asp Thr Thr Tyr Ile Asn 
225                 230                 235                 240 


His Val Val Ser Val Ala Gly Trp Gly Ile Ser Asp Gly Thr Glu Tyr 
                245                 250                 255     


Trp Ile Val Arg Asn Ser Trp Gly Glu Pro Trp Gly Glu Arg Gly Trp 
            260                 265                 270         


Leu Arg Ile Val Thr Ser Thr Tyr Lys Asp Gly Lys Gly Ala Arg Tyr 
        275                 280                 285             


Asn Leu Ala Ile Glu Glu His Cys Thr Phe Gly Asp Pro Ile Val 
    290                 295                 300             


<210>  3772
<211>  3623
<212>  PRT
<213>  Homo Sapiens

<400>  3772

Met Met Asn Met Ser Leu Pro Phe Leu Trp Ser Leu Leu Thr Leu Leu 
1               5                   10                  15      


Ile Phe Ala Glu Val Asn Gly Glu Ala Gly Glu Leu Glu Leu Gln Arg 
            20                  25                  30          


Gln Lys Arg Ser Ile Asn Leu Gln Gln Pro Arg Met Ala Thr Glu Arg 
        35                  40                  45              


Gly Asn Leu Val Phe Leu Thr Gly Ser Ala Gln Asn Ile Glu Phe Arg 
    50                  55                  60                  


Thr Gly Ser Leu Gly Lys Ile Lys Leu Asn Asp Glu Asp Leu Ser Glu 
65                  70                  75                  80  


Cys Leu His Gln Ile Gln Lys Asn Lys Glu Asp Ile Ile Glu Leu Lys 
                85                  90                  95      


Gly Ser Ala Ile Gly Leu Pro Gln Asn Ile Ser Ser Gln Ile Tyr Gln 
            100                 105                 110         


Leu Asn Ser Lys Leu Val Asp Leu Glu Arg Lys Phe Gln Gly Leu Gln 
        115                 120                 125             


Gln Thr Val Asp Lys Lys Val Cys Ser Ser Asn Pro Cys Gln Asn Gly 
    130                 135                 140                 


Gly Thr Cys Leu Asn Leu His Asp Ser Phe Phe Cys Ile Cys Pro Pro 
145                 150                 155                 160 


Gln Trp Lys Gly Pro Leu Cys Ser Ala Asp Val Asn Glu Cys Glu Ile 
                165                 170                 175     


Tyr Ser Gly Thr Pro Leu Ser Cys Gln Asn Gly Gly Thr Cys Val Asn 
            180                 185                 190         


Thr Met Gly Ser Tyr Ser Cys His Cys Pro Pro Glu Thr Tyr Gly Pro 
        195                 200                 205             


Gln Cys Ala Ser Lys Tyr Asp Asp Cys Glu Gly Gly Ser Val Ala Arg 
    210                 215                 220                 


Cys Val His Gly Ile Cys Glu Asp Leu Met Arg Glu Gln Ala Gly Glu 
225                 230                 235                 240 


Pro Lys Tyr Ser Cys Val Cys Asp Ala Gly Trp Met Phe Ser Pro Asn 
                245                 250                 255     


Ser Pro Ala Cys Thr Leu Asp Arg Asp Glu Cys Ser Phe Gln Pro Gly 
            260                 265                 270         


Pro Cys Ser Thr Leu Val Gln Cys Phe Asn Thr Gln Gly Ser Phe Tyr 
        275                 280                 285             


Cys Gly Ala Cys Pro Thr Gly Trp Gln Gly Asn Gly Tyr Ile Cys Glu 
    290                 295                 300                 


Asp Ile Asn Glu Cys Glu Ile Asn Asn Gly Gly Cys Ser Val Ala Pro 
305                 310                 315                 320 


Pro Val Glu Cys Val Asn Thr Pro Gly Ser Ser His Cys Gln Ala Cys 
                325                 330                 335     


Pro Pro Gly Tyr Gln Gly Asp Gly Arg Val Cys Thr Leu Thr Asp Ile 
            340                 345                 350         


Cys Ser Val Ser Asn Gly Gly Cys His Pro Asp Ala Ser Cys Ser Ser 
        355                 360                 365             


Thr Leu Gly Ser Leu Pro Leu Cys Thr Cys Leu Pro Gly Tyr Thr Gly 
    370                 375                 380                 


Asn Gly Tyr Gly Pro Asn Gly Cys Val Gln Leu Ser Asn Ile Cys Leu 
385                 390                 395                 400 


Ser His Pro Cys Leu Asn Gly Gln Cys Ile Asp Thr Val Ser Gly Tyr 
                405                 410                 415     


Phe Cys Lys Cys Asp Ser Gly Trp Thr Gly Val Asn Cys Thr Glu Asn 
            420                 425                 430         


Ile Asn Glu Cys Leu Ser Asn Pro Cys Leu Asn Gly Gly Thr Cys Val 
        435                 440                 445             


Asp Gly Val Asp Ser Phe Ser Cys Glu Cys Thr Arg Leu Trp Thr Gly 
    450                 455                 460                 


Ala Leu Cys Gln Val Pro Gln Gln Val Cys Gly Glu Ser Leu Ser Gly 
465                 470                 475                 480 


Ile Asn Gly Ser Phe Ser Tyr Arg Ser Pro Asp Val Gly Tyr Val His 
                485                 490                 495     


Asp Val Asn Cys Phe Trp Val Ile Lys Thr Glu Met Gly Lys Val Leu 
            500                 505                 510         


Arg Ile Thr Phe Thr Phe Phe Arg Leu Glu Ser Met Asp Asn Cys Pro 
        515                 520                 525             


His Glu Phe Leu Gln Val Tyr Asp Gly Asp Ser Ser Ser Ala Phe Gln 
    530                 535                 540                 


Leu Gly Arg Phe Cys Gly Ser Ser Leu Pro His Glu Leu Leu Ser Ser 
545                 550                 555                 560 


Asp Asn Ala Leu Tyr Phe His Leu Tyr Ser Glu His Leu Arg Asn Gly 
                565                 570                 575     


Arg Gly Phe Thr Val Arg Trp Glu Thr Gln Gln Pro Glu Cys Gly Gly 
            580                 585                 590         


Ile Leu Thr Gly Pro Tyr Gly Ser Ile Lys Ser Pro Gly Tyr Pro Gly 
        595                 600                 605             


Asn Tyr Pro Pro Gly Arg Asp Cys Val Trp Ile Val Val Thr Ser Pro 
    610                 615                 620                 


Asp Leu Leu Val Thr Phe Thr Phe Gly Thr Leu Ser Leu Glu His His 
625                 630                 635                 640 


Asp Asp Cys Asn Lys Asp Tyr Leu Glu Ile Arg Asp Gly Pro Leu Tyr 
                645                 650                 655     


Gln Asp Pro Leu Leu Gly Lys Phe Cys Thr Thr Phe Ser Val Pro Pro 
            660                 665                 670         


Leu Gln Thr Thr Gly Pro Phe Ala Arg Ile His Phe His Ser Asp Ser 
        675                 680                 685             


Gln Ile Ser Asp Gln Gly Phe His Ile Thr Tyr Leu Thr Ser Pro Ser 
    690                 695                 700                 


Asp Leu Arg Cys Gly Gly Asn Tyr Thr Asp Pro Glu Gly Glu Leu Phe 
705                 710                 715                 720 


Leu Pro Glu Leu Ser Gly Pro Phe Thr His Thr Arg Gln Cys Val Tyr 
                725                 730                 735     


Met Met Lys Gln Pro Gln Gly Glu Gln Ile Gln Ile Asn Phe Thr His 
            740                 745                 750         


Val Glu Leu Gln Cys Gln Ser Asp Ser Ser Gln Asn Tyr Ile Glu Val 
        755                 760                 765             


Arg Asp Gly Glu Thr Leu Leu Gly Lys Val Cys Gly Asn Gly Thr Ile 
    770                 775                 780                 


Ser His Ile Lys Ser Ile Thr Asn Ser Val Trp Ile Arg Phe Lys Ile 
785                 790                 795                 800 


Asp Ala Ser Val Glu Lys Ala Ser Phe Arg Ala Val Tyr Gln Val Ala 
                805                 810                 815     


Cys Gly Asp Glu Leu Thr Gly Glu Gly Val Ile Arg Ser Pro Phe Phe 
            820                 825                 830         


Pro Asn Val Tyr Pro Gly Glu Arg Thr Cys Arg Trp Thr Ile His Gln 
        835                 840                 845             


Pro Gln Ser Gln Val Ile Leu Leu Asn Phe Thr Val Phe Glu Ile Gly 
    850                 855                 860                 


Ser Ser Ala His Cys Glu Thr Asp Tyr Val Glu Ile Gly Ser Ser Ser 
865                 870                 875                 880 


Ile Leu Gly Ser Pro Glu Asn Lys Lys Tyr Cys Gly Thr Asp Ile Pro 
                885                 890                 895     


Ser Phe Ile Thr Ser Val Tyr Asn Phe Leu Tyr Val Thr Phe Val Lys 
            900                 905                 910         


Ser Ser Ser Thr Glu Asn His Gly Phe Met Ala Lys Phe Ser Ala Glu 
        915                 920                 925             


Asp Leu Ala Cys Gly Glu Ile Leu Thr Glu Ser Thr Gly Thr Ile Gln 
    930                 935                 940                 


Ser Pro Gly His Pro Asn Val Tyr Pro His Gly Ile Asn Cys Thr Trp 
945                 950                 955                 960 


His Ile Leu Val Gln Pro Asn His Leu Ile His Leu Met Phe Glu Thr 
                965                 970                 975     


Phe His Leu Glu Phe His Tyr Asn Cys Thr Asn Asp Tyr Leu Glu Val 
            980                 985                 990         


Tyr Asp Thr Asp Ser Glu Thr Ser  Leu Gly Arg Tyr Cys  Gly Lys Ser 
        995                 1000                 1005             


Ile Pro  Pro Ser Leu Thr Ser  Ser Gly Asn Ser Leu  Met Leu Val 
    1010                 1015                 1020             


Phe Val  Thr Asp Ser Asp Leu  Ala Tyr Glu Gly Phe  Leu Ile Asn 
    1025                 1030                 1035             


Tyr Glu  Ala Ile Ser Ala Ala  Thr Ala Cys Leu Gln  Asp Tyr Thr 
    1040                 1045                 1050             


Asp Asp  Leu Gly Thr Phe Thr  Ser Pro Asn Phe Pro  Asn Asn Tyr 
    1055                 1060                 1065             


Pro Asn  Asn Trp Glu Cys Ile  Tyr Arg Ile Thr Val  Arg Thr Gly 
    1070                 1075                 1080             


Gln Leu  Ile Ala Val His Phe  Thr Asn Phe Ser Leu  Glu Glu Ala 
    1085                 1090                 1095             


Ile Gly  Asn Tyr Tyr Thr Asp  Phe Leu Glu Ile Arg  Asp Gly Gly 
    1100                 1105                 1110             


Tyr Glu  Lys Ser Pro Leu Leu  Gly Ile Phe Tyr Gly  Ser Asn Leu 
    1115                 1120                 1125             


Pro Pro  Thr Ile Ile Ser His  Ser Asn Lys Leu Trp  Leu Lys Phe 
    1130                 1135                 1140             


Lys Ser  Asp Gln Ile Asp Thr  Arg Ser Gly Phe Ser  Ala Tyr Trp 
    1145                 1150                 1155             


Asp Gly  Ser Ser Thr Gly Cys  Gly Gly Asn Leu Thr  Thr Ser Ser 
    1160                 1165                 1170             


Gly Thr  Phe Ile Ser Pro Asn  Tyr Pro Met Pro Tyr  Tyr His Ser 
    1175                 1180                 1185             


Ser Glu  Cys Tyr Trp Trp Leu  Lys Ser Ser His Gly  Ser Ala Phe 
    1190                 1195                 1200             


Glu Leu  Glu Phe Lys Asp Phe  His Leu Glu His His  Pro Asn Cys 
    1205                 1210                 1215             


Thr Leu  Asp Tyr Leu Ala Val  Tyr Asp Gly Pro Ser  Ser Asn Ser 
    1220                 1225                 1230             


His Leu  Leu Thr Gln Leu Cys  Gly Asp Glu Lys Pro  Pro Leu Ile 
    1235                 1240                 1245             


Arg Ser  Ser Gly Asp Ser Met  Phe Ile Lys Leu Arg  Thr Asp Glu 
    1250                 1255                 1260             


Gly Gln  Gln Gly Arg Gly Phe  Lys Ala Glu Tyr Arg  Gln Thr Cys 
    1265                 1270                 1275             


Glu Asn  Val Val Ile Val Asn  Gln Thr Tyr Gly Ile  Leu Glu Ser 
    1280                 1285                 1290             


Ile Gly  Tyr Pro Asn Pro Tyr  Ser Glu Asn Gln His  Cys Asn Trp 
    1295                 1300                 1305             


Thr Ile  Arg Ala Thr Thr Gly  Asn Thr Val Asn Tyr  Thr Phe Leu 
    1310                 1315                 1320             


Ala Phe  Asp Leu Glu His His  Ile Asn Cys Ser Thr  Asp Tyr Leu 
    1325                 1330                 1335             


Glu Leu  Tyr Asp Gly Pro Arg  Gln Met Gly Arg Tyr  Cys Gly Val 
    1340                 1345                 1350             


Asp Leu  Pro Pro Pro Gly Ser  Thr Thr Ser Ser Lys  Leu Gln Val 
    1355                 1360                 1365             


Leu Leu  Leu Thr Asp Gly Val  Gly Arg Arg Glu Lys  Gly Phe Gln 
    1370                 1375                 1380             


Met Gln  Trp Phe Val Tyr Gly  Cys Gly Gly Glu Leu  Ser Gly Ala 
    1385                 1390                 1395             


Thr Gly  Ser Phe Ser Ser Pro  Gly Phe Pro Asn Arg  Tyr Pro Pro 
    1400                 1405                 1410             


Asn Lys  Glu Cys Ile Trp Tyr  Ile Arg Thr Asp Pro  Gly Ser Ser 
    1415                 1420                 1425             


Ile Gln  Leu Thr Ile His Asp  Phe Asp Val Glu Tyr  His Ser Arg 
    1430                 1435                 1440             


Cys Asn  Phe Asp Val Leu Glu  Ile Tyr Gly Gly Pro  Asp Phe His 
    1445                 1450                 1455             


Ser Pro  Arg Ile Ala Gln Leu  Cys Thr Gln Arg Ser  Pro Glu Asn 
    1460                 1465                 1470             


Pro Met  Gln Val Ser Ser Thr  Gly Asn Glu Leu Ala  Ile Arg Phe 
    1475                 1480                 1485             


Lys Thr  Asp Leu Ser Ile Asn  Gly Arg Gly Phe Asn  Ala Ser Trp 
    1490                 1495                 1500             


Gln Ala  Val Thr Gly Gly Cys  Gly Gly Ile Phe Gln  Ala Pro Ser 
    1505                 1510                 1515             


Gly Glu  Ile His Ser Pro Asn  Tyr Pro Ser Pro Tyr  Arg Ser Asn 
    1520                 1525                 1530             


Thr Asp  Cys Ser Trp Val Ile  Arg Val Asp Arg Asn  His Arg Val 
    1535                 1540                 1545             


Leu Leu  Asn Phe Thr Asp Phe  Asp Leu Glu Pro Gln  Asp Ser Cys 
    1550                 1555                 1560             


Ile Met  Ala Tyr Asp Gly Leu  Ser Ser Thr Met Ser  Arg Leu Ala 
    1565                 1570                 1575             


Arg Thr  Cys Gly Arg Glu Gln  Leu Ala Asn Pro Ile  Val Ser Ser 
    1580                 1585                 1590             


Gly Asn  Ser Leu Phe Leu Arg  Phe Gln Ser Gly Pro  Ser Arg Gln 
    1595                 1600                 1605             


Asn Arg  Gly Phe Arg Ala Gln  Phe Arg Gln Ala Cys  Gly Gly His 
    1610                 1615                 1620             


Ile Leu  Thr Ser Ser Phe Asp  Thr Val Ser Ser Pro  Arg Phe Pro 
    1625                 1630                 1635             


Ala Asn  Tyr Pro Asn Asn Gln  Asn Cys Ser Trp Ile  Ile Gln Ala 
    1640                 1645                 1650             


Gln Pro  Pro Leu Asn His Ile  Thr Leu Ser Phe Thr  His Phe Glu 
    1655                 1660                 1665             


Leu Glu  Arg Ser Thr Thr Cys  Ala Arg Asp Phe Val  Glu Ile Leu 
    1670                 1675                 1680             


Asp Gly  Gly His Glu Asp Ala  Pro Leu Arg Gly Arg  Tyr Cys Gly 
    1685                 1690                 1695             


Thr Asp  Met Pro His Pro Ile  Thr Ser Phe Ser Ser  Ala Leu Thr 
    1700                 1705                 1710             


Leu Arg  Phe Val Ser Asp Ser  Ser Ile Ser Ala Gly  Gly Phe His 
    1715                 1720                 1725             


Thr Thr  Val Thr Ala Ser Val  Ser Ala Cys Gly Gly  Thr Phe Tyr 
    1730                 1735                 1740             


Met Ala  Glu Gly Ile Phe Asn  Ser Pro Gly Tyr Pro  Asp Ile Tyr 
    1745                 1750                 1755             


Pro Pro  Asn Val Glu Cys Val  Trp Asn Ile Val Ser  Ser Pro Gly 
    1760                 1765                 1770             


Asn Arg  Leu Gln Leu Ser Phe  Ile Ser Phe Gln Leu  Glu Asp Ser 
    1775                 1780                 1785             


Gln Asp  Cys Ser Arg Asp Phe  Val Glu Ile Arg Glu  Gly Asn Ala 
    1790                 1795                 1800             


Thr Gly  His Leu Val Gly Arg  Tyr Cys Gly Asn Ser  Phe Pro Leu 
    1805                 1810                 1815             


Asn Tyr  Ser Ser Ile Val Gly  His Thr Leu Trp Val  Arg Phe Ile 
    1820                 1825                 1830             


Ser Asp  Gly Ser Gly Ser Gly  Thr Gly Phe Gln Ala  Thr Phe Met 
    1835                 1840                 1845             


Lys Ile  Phe Gly Asn Asp Asn  Ile Val Gly Thr His  Gly Lys Val 
    1850                 1855                 1860             


Ala Ser  Pro Phe Trp Pro Glu  Asn Tyr Pro His Asn  Ser Asn Tyr 
    1865                 1870                 1875             


Gln Trp  Thr Val Asn Val Asn  Ala Ser His Val Val  His Gly Arg 
    1880                 1885                 1890             


Ile Leu  Glu Met Asp Ile Glu  Glu Ile Gln Asn Cys  Tyr Tyr Asp 
    1895                 1900                 1905             


Lys Leu  Arg Ile Tyr Asp Gly  Pro Ser Ile His Ala  Arg Leu Ile 
    1910                 1915                 1920             


Gly Ala  Tyr Cys Gly Thr Gln  Thr Glu Ser Phe Ser  Ser Thr Gly 
    1925                 1930                 1935             


Asn Ser  Leu Thr Phe His Phe  Tyr Ser Asp Ser Ser  Ile Ser Gly 
    1940                 1945                 1950             


Lys Gly  Phe Leu Leu Glu Trp  Phe Ala Val Asp Ala  Pro Asp Gly 
    1955                 1960                 1965             


Val Leu  Pro Thr Ile Ala Pro  Gly Ala Cys Gly Gly  Phe Leu Arg 
    1970                 1975                 1980             


Thr Gly  Asp Ala Pro Val Phe  Leu Phe Ser Pro Gly  Trp Pro Asp 
    1985                 1990                 1995             


Ser Tyr  Ser Asn Arg Val Asp  Cys Thr Trp Leu Ile  Gln Ala Pro 
    2000                 2005                 2010             


Asp Ser  Thr Val Glu Leu Asn  Ile Leu Ser Leu Asp  Ile Glu Ser 
    2015                 2020                 2025             


His Arg  Thr Cys Ala Tyr Asp  Ser Leu Val Ile Arg  Asp Gly Asp 
    2030                 2035                 2040             


Asn Asn  Leu Ala Gln Gln Leu  Ala Val Leu Cys Gly  Arg Glu Ile 
    2045                 2050                 2055             


Pro Gly  Pro Ile Arg Ser Thr  Gly Glu Tyr Met Phe  Ile Arg Phe 
    2060                 2065                 2070             


Thr Ser  Asp Ser Ser Val Thr  Arg Ala Gly Phe Asn  Ala Ser Phe 
    2075                 2080                 2085             


His Lys  Ser Cys Gly Gly Tyr  Leu His Ala Asp Arg  Gly Ile Ile 
    2090                 2095                 2100             


Thr Ser  Pro Lys Tyr Pro Glu  Thr Tyr Pro Ser Asn  Leu Asn Cys 
    2105                 2110                 2115             


Ser Trp  His Val Leu Val Gln  Ser Gly Leu Thr Ile  Ala Val His 
    2120                 2125                 2130             


Phe Glu  Gln Pro Phe Gln Ile  Pro Asn Gly Asp Ser  Ser Cys Asn 
    2135                 2140                 2145             


Gln Gly  Asp Tyr Leu Val Leu  Arg Asn Gly Pro Asp  Ile Cys Ser 
    2150                 2155                 2160             


Pro Pro  Leu Gly Pro Pro Gly  Gly Asn Gly His Phe  Cys Gly Ser 
    2165                 2170                 2175             


His Ala  Ser Ser Thr Leu Phe  Thr Ser Asp Asn Gln  Met Phe Val 
    2180                 2185                 2190             


Gln Phe  Ile Ser Asp His Ser  Asn Glu Gly Gln Gly  Phe Lys Ile 
    2195                 2200                 2205             


Lys Tyr  Glu Ala Lys Ser Leu  Ala Cys Gly Gly Asn  Val Tyr Ile 
    2210                 2215                 2220             


His Asp  Ala Asp Ser Ala Gly  Tyr Val Thr Ser Pro  Asn His Pro 
    2225                 2230                 2235             


His Asn  Tyr Pro Pro His Ala  Asp Cys Ile Trp Ile  Leu Ala Ala 
    2240                 2245                 2250             


Pro Pro  Glu Thr Arg Ile Gln  Leu Gln Phe Glu Asp  Arg Phe Asp 
    2255                 2260                 2265             


Ile Glu  Val Thr Pro Asn Cys  Thr Ser Asn Tyr Leu  Glu Leu Arg 
    2270                 2275                 2280             


Asp Gly  Val Asp Ser Asp Ala  Pro Ile Leu Ser Lys  Phe Cys Gly 
    2285                 2290                 2295             


Thr Ser  Leu Pro Ser Ser Gln  Trp Ser Ser Gly Glu  Val Met Tyr 
    2300                 2305                 2310             


Leu Arg  Phe Arg Ser Asp Asn  Ser Pro Thr His Val  Gly Phe Lys 
    2315                 2320                 2325             


Ala Lys  Tyr Ser Ile Ala Gln  Cys Gly Gly Arg Val  Pro Gly Gln 
    2330                 2335                 2340             


Ser Gly  Val Val Glu Ser Ile  Gly His Pro Thr Leu  Pro Tyr Arg 
    2345                 2350                 2355             


Asp Asn  Leu Phe Cys Glu Trp  His Leu Gln Gly Leu  Ser Gly His 
    2360                 2365                 2370             


Tyr Leu  Thr Ile Ser Phe Glu  Asp Phe Asn Leu Gln  Asn Ser Ser 
    2375                 2380                 2385             


Gly Cys  Glu Lys Asp Phe Val  Glu Ile Trp Asp Asn  His Thr Ser 
    2390                 2395                 2400             


Gly Asn  Ile Leu Gly Arg Tyr  Cys Gly Asn Thr Ile  Pro Asp Ser 
    2405                 2410                 2415             


Ile Asp  Thr Ser Ser Asn Thr  Ala Val Val Arg Phe  Val Thr Asp 
    2420                 2425                 2430             


Gly Ser  Val Thr Ala Ser Gly  Phe Arg Leu Arg Phe  Glu Ser Ser 
    2435                 2440                 2445             


Met Glu  Glu Cys Gly Gly Asp  Leu Gln Gly Ser Ile  Gly Thr Phe 
    2450                 2455                 2460             


Thr Ser  Pro Asn Tyr Pro Asn  Pro Asn Pro His Gly  Arg Ile Cys 
    2465                 2470                 2475             


Glu Trp  Arg Ile Thr Ala Pro  Glu Gly Arg Arg Ile  Thr Leu Met 
    2480                 2485                 2490             


Phe Asn  Asn Leu Arg Leu Ala  Thr His Pro Ser Cys  Asn Asn Glu 
    2495                 2500                 2505             


His Val  Ile Val Phe Asn Gly  Ile Arg Ser Asn Ser  Pro Gln Leu 
    2510                 2515                 2520             


Glu Lys  Leu Cys Ser Ser Val  Asn Val Ser Asn Glu  Ile Lys Ser 
    2525                 2530                 2535             


Ser Gly  Asn Thr Met Lys Val  Ile Phe Phe Thr Asp  Gly Ser Arg 
    2540                 2545                 2550             


Pro Tyr  Gly Gly Phe Thr Ala  Ser Tyr Thr Ser Ser  Glu Asp Ala 
    2555                 2560                 2565             


Val Cys  Gly Gly Ser Leu Pro  Asn Thr Pro Glu Gly  Asn Phe Thr 
    2570                 2575                 2580             


Ser Pro  Gly Tyr Asp Gly Val  Arg Asn Tyr Ser Arg  Asn Leu Asn 
    2585                 2590                 2595             


Cys Glu  Trp Thr Leu Ser Asn  Pro Asn Gln Gly Asn  Ser Ser Ile 
    2600                 2605                 2610             


Ser Ile  His Phe Glu Asp Phe  Tyr Leu Glu Ser His  Gln Asp Cys 
    2615                 2620                 2625             


Gln Phe  Asp Val Leu Glu Phe  Arg Val Gly Asp Ala  Asp Gly Pro 
    2630                 2635                 2640             


Leu Met  Trp Arg Leu Cys Gly  Pro Ser Lys Pro Thr  Leu Pro Leu 
    2645                 2650                 2655             


Val Ile  Pro Tyr Ser Gln Val  Trp Ile His Phe Val  Thr Asn Glu 
    2660                 2665                 2670             


Arg Val  Glu His Ile Gly Phe  His Ala Lys Tyr Ser  Phe Thr Asp 
    2675                 2680                 2685             


Cys Gly  Gly Ile Gln Ile Gly  Asp Ser Gly Val Ile  Thr Ser Pro 
    2690                 2695                 2700             


Asn Tyr  Pro Asn Ala Tyr Asp  Ser Leu Thr His Cys  Ser Ser Leu 
    2705                 2710                 2715             


Leu Glu  Ala Pro Gln Gly His  Thr Ile Thr Leu Thr  Phe Ser Asp 
    2720                 2725                 2730             


Phe Asp  Ile Glu Pro His Thr  Thr Cys Ala Trp Asp  Ser Val Thr 
    2735                 2740                 2745             


Val Arg  Asn Gly Gly Ser Pro  Glu Ser Pro Ile Ile  Gly Gln Tyr 
    2750                 2755                 2760             


Cys Gly  Asn Ser Asn Pro Arg  Thr Ile Gln Ser Gly  Ser Asn Gln 
    2765                 2770                 2775             


Leu Val  Val Thr Phe Asn Ser  Asp His Ser Leu Gln  Gly Gly Gly 
    2780                 2785                 2790             


Phe Tyr  Ala Thr Trp Asn Thr  Gln Thr Leu Gly Cys  Gly Gly Ile 
    2795                 2800                 2805             


Phe His  Ser Asp Asn Gly Thr  Ile Arg Ser Pro His  Trp Pro Gln 
    2810                 2815                 2820             


Asn Phe  Pro Glu Asn Ser Arg  Cys Ser Trp Thr Ala  Ile Thr His 
    2825                 2830                 2835             


Lys Ser  Lys His Leu Glu Ile  Ser Phe Asp Asn Asn  Phe Leu Ile 
    2840                 2845                 2850             


Pro Ser  Gly Asp Gly Gln Cys  Gln Asn Ser Phe Val  Lys Val Trp 
    2855                 2860                 2865             


Ala Gly  Thr Glu Glu Val Asp  Lys Ala Leu Leu Ala  Thr Gly Cys 
    2870                 2875                 2880             


Gly Asn  Val Ala Pro Gly Pro  Val Ile Thr Pro Ser  Asn Thr Phe 
    2885                 2890                 2895             


Thr Ala  Val Phe Gln Ser Gln  Glu Ala Pro Ala Gln  Gly Phe Ser 
    2900                 2905                 2910             


Ala Ser  Phe Val Ser Arg Cys  Gly Ser Asn Phe Thr  Gly Pro Ser 
    2915                 2920                 2925             


Gly Tyr  Ile Ile Ser Pro Asn  Tyr Pro Lys Gln Tyr  Asp Asn Asn 
    2930                 2935                 2940             


Met Asn  Cys Thr Tyr Val Ile  Glu Ala Asn Pro Leu  Ser Val Val 
    2945                 2950                 2955             


Leu Leu  Thr Phe Val Ser Phe  His Leu Glu Ala Arg  Ser Ala Val 
    2960                 2965                 2970             


Thr Gly  Ser Cys Val Asn Asp  Gly Val His Ile Ile  Arg Gly Tyr 
    2975                 2980                 2985             


Ser Val  Met Ser Thr Pro Phe  Ala Thr Val Cys Gly  Asp Glu Met 
    2990                 2995                 3000             


Pro Ala  Pro Leu Thr Ile Ala  Gly Pro Val Leu Leu  Asn Phe Tyr 
    3005                 3010                 3015             


Ser Asn  Glu Gln Ile Thr Asp  Phe Gly Phe Lys Phe  Ser Tyr Arg 
    3020                 3025                 3030             


Ile Ile  Ser Cys Gly Gly Val  Phe Asn Phe Ser Ser  Gly Ile Ile 
    3035                 3040                 3045             


Thr Ser  Pro Ala Tyr Ser Tyr  Ala Asp Tyr Pro Asn  Asp Met His 
    3050                 3055                 3060             


Cys Leu  Tyr Thr Ile Thr Val  Ser Asp Asp Lys Val  Ile Glu Leu 
    3065                 3070                 3075             


Lys Phe  Ser Asp Phe Asp Val  Val Pro Ser Thr Ser  Cys Ser His 
    3080                 3085                 3090             


Asp Tyr  Leu Ala Ile Tyr Asp  Gly Ala Asn Thr Ser  Asp Pro Leu 
    3095                 3100                 3105             


Leu Gly  Lys Phe Cys Gly Ser  Lys Arg Pro Pro Asn  Val Lys Ser 
    3110                 3115                 3120             


Ser Asn  Asn Ser Met Leu Leu  Val Phe Lys Thr Asp  Ser Phe Gln 
    3125                 3130                 3135             


Thr Ala  Lys Gly Trp Lys Met  Ser Phe Arg Gln Thr  Leu Gly Pro 
    3140                 3145                 3150             


Gln Gln  Gly Cys Gly Gly Tyr  Leu Thr Gly Ser Asn  Asn Thr Phe 
    3155                 3160                 3165             


Ala Ser  Pro Asp Ser Asp Ser  Asn Gly Met Tyr Asp  Lys Asn Leu 
    3170                 3175                 3180             


Asn Cys  Val Trp Ile Ile Ile  Ala Pro Val Asn Lys  Val Ile His 
    3185                 3190                 3195             


Leu Thr  Phe Asn Thr Phe Ala  Leu Glu Ala Ala Ser  Thr Arg Gln 
    3200                 3205                 3210             


Arg Cys  Leu Tyr Asp Tyr Val  Lys Leu Tyr Asp Gly  Asp Ser Glu 
    3215                 3220                 3225             


Asn Ala  Asn Leu Ala Gly Thr  Phe Cys Gly Ser Thr  Val Pro Ala 
    3230                 3235                 3240             


Pro Phe  Ile Ser Ser Gly Asn  Phe Leu Thr Val Gln  Phe Ile Ser 
    3245                 3250                 3255             


Asp Leu  Thr Leu Glu Arg Glu  Gly Phe Asn Ala Thr  Tyr Thr Ile 
    3260                 3265                 3270             


Met Asp  Met Pro Cys Gly Gly  Thr Tyr Asn Ala Thr  Trp Thr Pro 
    3275                 3280                 3285             


Gln Asn  Ile Ser Ser Pro Asn  Ser Ser Asp Pro Asp  Val Pro Phe 
    3290                 3295                 3300             


Ser Ile  Cys Thr Trp Val Ile  Asp Ser Pro Pro His  Gln Gln Val 
    3305                 3310                 3315             


Lys Ile  Thr Val Trp Ala Leu  Gln Leu Thr Ser Gln  Asp Cys Thr 
    3320                 3325                 3330             


Gln Asn  Tyr Leu Gln Leu Gln  Asp Ser Pro Gln Gly  His Gly Asn 
    3335                 3340                 3345             


Ser Arg  Phe Gln Phe Cys Gly  Arg Asn Ala Ser Ala  Val Pro Val 
    3350                 3355                 3360             


Phe Tyr  Ser Ser Met Ser Thr  Ala Met Val Ile Phe  Lys Ser Gly 
    3365                 3370                 3375             


Val Val  Asn Arg Asn Ser Arg  Met Ser Phe Thr Tyr  Gln Ile Ala 
    3380                 3385                 3390             


Asp Cys  Asn Arg Asp Tyr His  Lys Ala Phe Gly Asn  Leu Arg Ser 
    3395                 3400                 3405             


Pro Gly  Trp Pro Asp Asn Tyr  Asp Asn Asp Lys Asp  Cys Thr Val 
    3410                 3415                 3420             


Thr Leu  Thr Ala Pro Gln Asn  His Thr Ile Ser Leu  Phe Phe His 
    3425                 3430                 3435             


Ser Leu  Gly Ile Glu Asn Ser  Val Glu Cys Arg Asn  Asp Phe Leu 
    3440                 3445                 3450             


Glu Val  Arg Asn Gly Ser Asn  Ser Asn Ser Pro Leu  Leu Gly Lys 
    3455                 3460                 3465             


Tyr Cys  Gly Thr Leu Leu Pro  Asn Pro Val Phe Ser  Gln Asn Asn 
    3470                 3475                 3480             


Glu Leu  Tyr Leu Arg Phe Lys  Ser Asp Ser Val Thr  Ser Asp Arg 
    3485                 3490                 3495             


Gly Tyr  Glu Ile Ile Trp Thr  Ser Ser Pro Ser Gly  Cys Gly Gly 
    3500                 3505                 3510             


Thr Leu  Tyr Gly Asp Arg Gly  Ser Phe Thr Ser Pro  Gly Tyr Pro 
    3515                 3520                 3525             


Gly Thr  Tyr Pro Asn Asn Thr  Tyr Cys Glu Trp Val  Leu Val Ala 
    3530                 3535                 3540             


Pro Ala  Gly Arg Leu Val Thr  Ile Asn Phe Tyr Phe  Ile Ser Ile 
    3545                 3550                 3555             


Asp Asp  Pro Gly Asp Cys Val  Gln Asn Tyr Leu Thr  Leu Tyr Asp 
    3560                 3565                 3570             


Gly Pro  Asn Ala Ser Ser Pro  Ser Ser Gly Pro Tyr  Cys Gly Gly 
    3575                 3580                 3585             


Asp Thr  Ser Ile Ala Pro Phe  Val Ala Ser Ser Asn  Gln Val Phe 
    3590                 3595                 3600             


Ile Lys  Phe His Ala Asp Tyr  Ala Arg Arg Pro Ser  Ala Phe Arg 
    3605                 3610                 3615             


Leu Thr  Trp Asp Ser 
    3620             


<210>  3773
<211>  170
<212>  PRT
<213>  Homo Sapiens

<400>  3773

Met Met Asn Met Ser Leu Pro Phe Leu Trp Ser Leu Leu Thr Leu Leu 
1               5                   10                  15      


Ile Phe Ala Glu Val Asn Gly Glu Ala Gly Glu Leu Glu Leu Gln Arg 
            20                  25                  30          


Gln Lys Arg Ser Ile Asn Leu Gln Gln Pro Arg Met Ala Thr Glu Arg 
        35                  40                  45              


Gly Asn Leu Val Phe Leu Thr Gly Ser Ala Gln Asn Ile Glu Phe Arg 
    50                  55                  60                  


Thr Gly Ser Leu Gly Lys Ile Lys Leu Asn Asp Glu Asp Leu Ser Glu 
65                  70                  75                  80  


Cys Leu His Gln Ile Gln Lys Asn Lys Glu Asp Ile Ile Glu Leu Lys 
                85                  90                  95      


Gly Ser Ala Ile Gly Leu Pro Gln Asn Ile Ser Ser Gln Ile Tyr Gln 
            100                 105                 110         


Leu Asn Ser Lys Leu Val Asp Leu Glu Arg Lys Phe Gln Gly Leu Gln 
        115                 120                 125             


Gln Thr Val Asp Lys Lys Val Cys Ser Ser Asn Pro Cys Gln Asn Gly 
    130                 135                 140                 


Gly Thr Cys Leu Asn Leu His Asp Ser Phe Phe Cys Ile Cys Pro Pro 
145                 150                 155                 160 


Gln Trp Lys Val Ser His Leu Leu Phe Gly 
                165                 170 


<210>  3774
<211>  105
<212>  PRT
<213>  Homo Sapiens

<400>  3774

Asn Ser Lys Leu Val Asp Leu Glu Arg Lys Phe Gln Gly Leu Gln Gln 
1               5                   10                  15      


Thr Val Asp Lys Lys Val Cys Ser Ser Asn Pro Cys Gln Asn Gly Gly 
            20                  25                  30          


Thr Cys Leu Asn Leu His Asp Ser Phe Phe Cys Ile Cys Pro Pro Gln 
        35                  40                  45              


Trp Lys Gly Pro Leu Cys Ser Ala Asp Val Asn Glu Cys Glu Ile Tyr 
    50                  55                  60                  


Ser Gly Thr Pro Leu Ser Cys Gln Asn Gly Gly Thr Cys Val Asn Thr 
65                  70                  75                  80  


Met Gly Ser Tyr Arg Asn Pro Cys Ser Asn Ile Pro Lys Glu Pro Glu 
                85                  90                  95      


Glu Gly Ser Arg Asp Trp His Arg Glu 
            100                 105 


<210>  3775
<211>  88
<212>  PRT
<213>  Homo Sapiens

<400>  3775

Ser Thr Gly Asn Glu Leu Ala Ile Arg Phe Lys Thr Asp Leu Ser Ile 
1               5                   10                  15      


Asn Gly Arg Gly Phe Asn Ala Ser Trp Gln Ala Val Thr Gly Gly Cys 
            20                  25                  30          


Gly Gly Ile Phe Gln Ala Pro Ser Gly Glu Ile His Ser Pro Asn Tyr 
        35                  40                  45              


Pro Ser Pro Tyr Arg Ser Asn Thr Asp Cys Ser Trp Val Ile Arg Val 
    50                  55                  60                  


Asp Arg Asn His Arg Val Leu Leu Asn Phe Thr Asp Phe Asp Leu Glu 
65                  70                  75                  80  


Pro Gln Asp Ser Cys Ile Met Val 
                85              


<210>  3776
<211>  198
<212>  PRT
<213>  Homo Sapiens

<400>  3776

Met Ile Gly Ser Gly Leu Ala Gly Ser Gly Gly Ala Gly Gly Pro Ser 
1               5                   10                  15      


Ser Thr Val Thr Trp Cys Ala Leu Phe Ser Asn His Val Ala Ala Thr 
            20                  25                  30          


Gln Ala Ser Leu Leu Leu Ser Phe Val Trp Met Pro Ala Leu Leu Pro 
        35                  40                  45              


Val Ala Ser Arg Leu Leu Leu Leu Pro Arg Val Leu Leu Thr Met Ala 
    50                  55                  60                  


Ser Gly Ser Pro Pro Thr Gln Pro Ser Pro Ala Ser Asp Ser Gly Ser 
65                  70                  75                  80  


Gly Tyr Val Pro Gly Ser Val Ser Ala Ala Phe Val Thr Cys Pro Asn 
                85                  90                  95      


Glu Lys Val Ala Lys Glu Ile Ala Arg Ala Val Val Glu Lys Arg Leu 
            100                 105                 110         


Ala Ala Cys Val Asn Leu Ile Pro Gln Ile Thr Ser Ile Tyr Glu Trp 
        115                 120                 125             


Lys Gly Lys Ile Glu Glu Asp Ser Glu Val Leu Met Met Ile Lys Thr 
    130                 135                 140                 


Gln Ser Ser Leu Val Pro Ala Leu Thr Asp Phe Val Arg Ser Val His 
145                 150                 155                 160 


Pro Tyr Glu Val Ala Glu Val Ile Ala Leu Pro Val Glu Gln Gly Asn 
                165                 170                 175     


Phe Pro Tyr Leu Gln Trp Val Arg Gln Val Thr Glu Ser Val Ser Asp 
            180                 185                 190         


Ser Ile Thr Val Leu Pro 
        195             


<210>  3777
<211>  135
<212>  PRT
<213>  Homo Sapiens

<400>  3777

Met Pro Ala Leu Leu Pro Val Ala Ser Arg Leu Leu Leu Leu Pro Arg 
1               5                   10                  15      


Val Leu Leu Thr Met Ala Ser Gly Ser Pro Pro Thr Gln Pro Ser Pro 
            20                  25                  30          


Ala Ser Asp Ser Gly Ser Gly Tyr Val Pro Gly Ser Val Ser Ala Ala 
        35                  40                  45              


Phe Val Thr Cys Pro Asn Glu Lys Val Ala Lys Glu Ile Ala Arg Ala 
    50                  55                  60                  


Val Val Glu Lys Arg Leu Ala Ala Cys Val Asn Leu Ile Pro Gln Ile 
65                  70                  75                  80  


Thr Ser Ile Tyr Glu Trp Lys Gly Lys Ile Glu Glu Asp Ser Glu Val 
                85                  90                  95      


Leu Met Met Ile Lys Thr Gln Ser Ser Leu Val Pro Ala Leu Thr Asp 
            100                 105                 110         


Phe Val Arg Ser Val His Pro Tyr Glu Val Ala Glu Ser Cys His Asp 
        115                 120                 125             


Glu Pro Cys Ser Cys Ser Ser 
    130                 135 


<210>  3778
<211>  156
<212>  PRT
<213>  Homo Sapiens

<400>  3778

Met Pro Ala Leu Leu Pro Val Ala Ser Arg Leu Leu Leu Leu Pro Arg 
1               5                   10                  15      


Val Leu Leu Thr Met Ala Ser Gly Ser Pro Pro Thr Gln Pro Ser Pro 
            20                  25                  30          


Ala Ser Asp Ser Gly Ser Gly Tyr Val Pro Gly Ser Val Ser Ala Ala 
        35                  40                  45              


Phe Val Thr Cys Pro Asn Glu Lys Val Ala Lys Glu Ile Ala Arg Ala 
    50                  55                  60                  


Val Val Glu Lys Arg Leu Ala Ala Cys Val Asn Leu Ile Pro Gln Ile 
65                  70                  75                  80  


Thr Ser Ile Tyr Glu Trp Lys Gly Lys Ile Glu Glu Asp Ser Glu Val 
                85                  90                  95      


Leu Met Met Ile Lys Thr Gln Ser Ser Leu Val Pro Ala Leu Thr Asp 
            100                 105                 110         


Phe Val Arg Ser Val His Pro Tyr Glu Val Ala Glu Val Ile Ala Leu 
        115                 120                 125             


Pro Val Glu Gln Gly Asn Phe Pro Tyr Leu Gln Trp Val Arg Gln Val 
    130                 135                 140                 


Thr Glu Ser Val Ser Asp Ser Ile Thr Val Leu Pro 
145                 150                 155     


<210>  3779
<211>  156
<212>  PRT
<213>  Homo Sapiens

<400>  3779

Met Pro Ala Leu Leu Pro Val Ala Ser Arg Leu Leu Leu Leu Pro Arg 
1               5                   10                  15      


Val Leu Leu Thr Met Ala Ser Gly Ser Pro Pro Thr Gln Pro Ser Pro 
            20                  25                  30          


Ala Ser Asp Ser Gly Ser Gly Tyr Val Pro Gly Ser Val Ser Ala Ala 
        35                  40                  45              


Phe Val Thr Cys Pro Asn Glu Lys Val Ala Lys Glu Ile Ala Arg Ala 
    50                  55                  60                  


Val Val Glu Lys Arg Leu Ala Ala Cys Val Asn Leu Ile Pro Gln Ile 
65                  70                  75                  80  


Thr Ser Ile Tyr Glu Trp Lys Gly Lys Ile Glu Glu Asp Ser Glu Val 
                85                  90                  95      


Leu Met Met Ile Lys Thr Gln Ser Ser Leu Val Pro Ala Leu Thr Asp 
            100                 105                 110         


Phe Val Arg Ser Val His Pro Tyr Glu Val Ala Glu Val Ile Ala Leu 
        115                 120                 125             


Pro Val Glu Gln Gly Asn Phe Pro Tyr Leu Gln Trp Val Arg Gln Val 
    130                 135                 140                 


Thr Glu Ser Val Ser Asp Ser Ile Thr Val Leu Pro 
145                 150                 155     


<210>  3780
<211>  156
<212>  PRT
<213>  Homo Sapiens

<400>  3780

Met Pro Ala Leu Leu Pro Val Ala Ser Arg Leu Leu Leu Leu Pro Arg 
1               5                   10                  15      


Val Leu Leu Thr Met Ala Ser Gly Ser Pro Pro Thr Gln Pro Ser Pro 
            20                  25                  30          


Ala Ser Asp Ser Gly Ser Gly Tyr Val Pro Gly Ser Val Ser Ala Ala 
        35                  40                  45              


Phe Val Thr Cys Pro Asn Glu Lys Val Ala Lys Glu Ile Ala Arg Ala 
    50                  55                  60                  


Val Val Glu Lys Arg Leu Ala Ala Cys Val Asn Leu Ile Pro Gln Ile 
65                  70                  75                  80  


Thr Ser Ile Tyr Glu Trp Lys Gly Lys Ile Glu Glu Asp Ser Glu Val 
                85                  90                  95      


Leu Met Met Ile Lys Thr Gln Ser Ser Leu Val Pro Ala Leu Thr Asp 
            100                 105                 110         


Phe Val Arg Ser Val His Pro Tyr Glu Val Ala Glu Val Ile Ala Leu 
        115                 120                 125             


Pro Val Glu Gln Gly Asn Phe Pro Tyr Leu Gln Trp Val Arg Gln Val 
    130                 135                 140                 


Thr Glu Ser Val Ser Asp Ser Ile Thr Val Leu Pro 
145                 150                 155     


<210>  3781
<211>  156
<212>  PRT
<213>  Homo Sapiens

<400>  3781

Met Pro Ala Leu Leu Pro Val Ala Ser Arg Leu Leu Leu Leu Pro Arg 
1               5                   10                  15      


Val Leu Leu Thr Met Ala Ser Gly Ser Pro Pro Thr Gln Pro Ser Pro 
            20                  25                  30          


Ala Ser Asp Ser Gly Ser Gly Tyr Val Pro Gly Ser Val Ser Ala Ala 
        35                  40                  45              


Phe Val Thr Cys Pro Asn Glu Lys Val Ala Lys Glu Ile Ala Arg Ala 
    50                  55                  60                  


Val Val Glu Lys Arg Leu Ala Ala Cys Val Asn Leu Ile Pro Gln Ile 
65                  70                  75                  80  


Thr Ser Ile Tyr Glu Trp Lys Gly Lys Ile Glu Glu Asp Ser Glu Val 
                85                  90                  95      


Leu Met Met Ile Lys Thr Gln Ser Ser Leu Val Pro Ala Leu Thr Asp 
            100                 105                 110         


Phe Val Arg Ser Val His Pro Tyr Glu Val Ala Glu Val Ile Ala Leu 
        115                 120                 125             


Pro Val Glu Gln Gly Asn Phe Pro Tyr Leu Gln Trp Val Arg Gln Val 
    130                 135                 140                 


Thr Glu Ser Val Ser Asp Ser Ile Thr Val Leu Pro 
145                 150                 155     


<210>  3782
<211>  155
<212>  PRT
<213>  Homo Sapiens

<400>  3782

Met Ser Gly Gly Arg Ala Pro Ala Val Leu Leu Gly Gly Val Ala Ser 
1               5                   10                  15      


Leu Leu Leu Ser Phe Val Trp Met Pro Ala Leu Leu Pro Val Ala Ser 
            20                  25                  30          


Arg Leu Leu Leu Leu Pro Arg Val Leu Leu Thr Met Ala Ser Gly Ser 
        35                  40                  45              


Pro Pro Thr Gln Pro Ser Pro Ala Ser Asp Ser Gly Ser Gly Tyr Val 
    50                  55                  60                  


Pro Gly Ser Val Ser Ala Ala Phe Val Thr Cys Pro Asn Glu Lys Val 
65                  70                  75                  80  


Ala Lys Glu Ile Ala Arg Ala Val Val Glu Lys Arg Leu Ala Ala Cys 
                85                  90                  95      


Val Asn Leu Ile Pro Gln Ile Thr Ser Ile Tyr Glu Trp Lys Gly Lys 
            100                 105                 110         


Ile Glu Glu Asp Ser Glu Val Leu Met Phe Cys Ala Pro Leu Arg Ser 
        115                 120                 125             


Gly Arg Gly Asn Cys Ile Ala Cys Gly Thr Gly Glu Leu Ser Val Pro 
    130                 135                 140                 


Ala Val Gly Ala Pro Gly His Arg Val Ser Phe 
145                 150                 155 


<210>  3783
<211>  179
<212>  PRT
<213>  Homo Sapiens

<400>  3783

Met Ser Gly Gly Arg Ala Pro Ala Val Leu Leu Gly Gly Val Ala Ser 
1               5                   10                  15      


Leu Leu Leu Ser Phe Val Trp Met Pro Ala Leu Leu Pro Val Ala Ser 
            20                  25                  30          


Arg Leu Leu Leu Leu Pro Arg Val Leu Leu Thr Met Ala Ser Gly Ser 
        35                  40                  45              


Pro Pro Thr Gln Pro Ser Pro Ala Ser Asp Ser Gly Ser Gly Tyr Val 
    50                  55                  60                  


Pro Gly Ser Val Ser Ala Ala Phe Val Thr Cys Pro Asn Glu Lys Val 
65                  70                  75                  80  


Ala Lys Glu Ile Ala Arg Ala Val Val Glu Lys Arg Leu Ala Ala Cys 
                85                  90                  95      


Val Asn Leu Ile Pro Gln Ile Thr Ser Ile Tyr Glu Trp Lys Gly Lys 
            100                 105                 110         


Ile Glu Glu Asp Ser Glu Val Leu Met Met Ile Lys Thr Gln Ser Ser 
        115                 120                 125             


Leu Val Pro Ala Leu Thr Asp Phe Val Arg Ser Val His Pro Tyr Glu 
    130                 135                 140                 


Val Ala Glu Val Ile Ala Leu Pro Val Glu Gln Gly Asn Phe Pro Tyr 
145                 150                 155                 160 


Leu Gln Trp Val Arg Gln Val Thr Glu Ser Val Ser Asp Ser Ile Thr 
                165                 170                 175     


Val Leu Pro 
            


<210>  3784
<211>  42
<212>  PRT
<213>  Homo Sapiens

<400>  3784

Met Ser Gly Gly Arg Ala Pro Ala Val Leu Leu Gly Gly Val Val Ser 
1               5                   10                  15      


Asp Arg Pro Arg Pro Ala Pro Ser Gly Pro Arg Ser Leu Asp Arg Tyr 
            20                  25                  30          


Pro His Pro Lys Ser Gln Arg Leu Ala Pro 
        35                  40          


<210>  3785
<211>  111
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3785

Xaa Ser Ser Thr Val Thr Trp Cys Ala Leu Phe Ser Asn His Val Ala 
1               5                   10                  15      


Ala Thr Gln Ala Ser Leu Leu Leu Ser Phe Val Trp Met Pro Ala Leu 
            20                  25                  30          


Leu Pro Val Ala Ser Arg Leu Leu Leu Leu Pro Arg Val Leu Leu Thr 
        35                  40                  45              


Met Ala Ser Gly Ser Pro Pro Thr Gln Pro Ser Pro Ala Ser Asp Ser 
    50                  55                  60                  


Gly Ser Gly Tyr Val Pro Gly Ser Val Ser Ala Ala Phe Val Thr Cys 
65                  70                  75                  80  


Pro Asn Glu Lys Val Ala Lys Glu Ile Ala Arg Ala Val Val Glu Lys 
                85                  90                  95      


Arg Leu Ala Ala Cys Val Asn Leu Ile Pro Gln Ile Thr Ser Met 
            100                 105                 110     


<210>  3786
<211>  55
<212>  PRT
<213>  Homo Sapiens

<400>  3786

Met Ala Pro Ile Ser Leu Ser Trp Leu Leu Arg Leu Ala Thr Phe Cys 
1               5                   10                  15      


His Leu Thr Val Leu Leu Ala Ala Trp Arg Arg Asp Ser Thr Gly Cys 
            20                  25                  30          


Ser Val Pro Thr Arg Arg Ser Asn Gly Ser Arg Thr Arg Cys Ser Ile 
        35                  40                  45              


Trp Thr Ala Arg Leu Leu Pro 
    50                  55  


<210>  3787
<211>  397
<212>  PRT
<213>  Homo Sapiens

<400>  3787

Met Ala Pro Ile Ser Leu Ser Trp Leu Leu Arg Leu Ala Thr Phe Cys 
1               5                   10                  15      


His Leu Thr Val Leu Leu Ala Gly Gln His His Gly Val Thr Lys Cys 
            20                  25                  30          


Asn Ile Thr Cys Ser Lys Met Thr Ser Lys Ile Pro Val Ala Leu Leu 
        35                  40                  45              


Ile His Tyr Gln Gln Asn Gln Ala Ser Cys Gly Lys Arg Ala Ile Ile 
    50                  55                  60                  


Leu Glu Thr Arg Gln His Arg Leu Phe Cys Ala Asp Pro Lys Glu Gln 
65                  70                  75                  80  


Trp Val Lys Asp Ala Met Gln His Leu Asp Arg Gln Ala Ala Ala Leu 
                85                  90                  95      


Thr Arg Asn Gly Gly Thr Phe Glu Lys Gln Ile Gly Glu Val Lys Pro 
            100                 105                 110         


Arg Thr Thr Pro Ala Ala Gly Gly Met Asp Glu Ser Val Val Leu Glu 
        115                 120                 125             


Pro Glu Ala Thr Gly Glu Ser Ser Ser Leu Glu Pro Thr Pro Ser Ser 
    130                 135                 140                 


Gln Glu Ala Gln Arg Ala Leu Gly Thr Ser Pro Glu Leu Pro Thr Gly 
145                 150                 155                 160 


Val Thr Gly Ser Ser Gly Thr Arg Leu Pro Pro Thr Pro Lys Ala Gln 
                165                 170                 175     


Asp Gly Gly Pro Val Gly Thr Glu Leu Phe Arg Val Pro Pro Val Ser 
            180                 185                 190         


Thr Ala Ala Thr Trp Gln Ser Ser Ala Pro His Gln Pro Gly Pro Ser 
        195                 200                 205             


Leu Trp Ala Glu Ala Lys Thr Ser Glu Ala Pro Ser Thr Gln Asp Pro 
    210                 215                 220                 


Ser Thr Gln Ala Ser Thr Ala Ser Ser Pro Ala Pro Glu Glu Asn Ala 
225                 230                 235                 240 


Pro Ser Glu Gly Gln Arg Val Trp Gly Gln Gly Gln Ser Pro Arg Pro 
                245                 250                 255     


Glu Asn Ser Leu Glu Arg Glu Glu Met Gly Pro Val Pro Ala His Thr 
            260                 265                 270         


Asp Ala Phe Gln Asp Trp Gly Pro Gly Ser Met Ala His Val Ser Val 
        275                 280                 285             


Val Pro Val Ser Ser Glu Gly Thr Pro Ser Arg Glu Pro Val Ala Ser 
    290                 295                 300                 


Gly Ser Trp Thr Pro Lys Ala Glu Glu Pro Ile His Ala Thr Met Asp 
305                 310                 315                 320 


Pro Gln Arg Leu Gly Val Leu Ile Thr Pro Val Pro Asp Ala Gln Ala 
                325                 330                 335     


Ala Thr Arg Arg Gln Ala Val Gly Leu Leu Ala Phe Leu Gly Leu Leu 
            340                 345                 350         


Phe Cys Leu Gly Val Ala Met Phe Thr Tyr Gln Ser Leu Gln Gly Cys 
        355                 360                 365             


Pro Arg Lys Met Ala Gly Glu Met Ala Glu Gly Leu Arg Tyr Ile Pro 
    370                 375                 380                 


Arg Ser Cys Gly Ser Asn Ser Tyr Val Leu Val Pro Val 
385                 390                 395         


<210>  3788
<211>  403
<212>  PRT
<213>  Homo Sapiens

<400>  3788

Met Ala Pro Ile Ser Leu Ser Trp Leu Leu Arg Leu Ala Thr Phe Cys 
1               5                   10                  15      


His Leu Thr Val Leu Leu Ala Gly Thr Ser Leu Asn Ser Gly Gln His 
            20                  25                  30          


His Gly Val Thr Lys Cys Asn Ile Thr Cys Ser Lys Met Thr Ser Lys 
        35                  40                  45              


Ile Pro Val Ala Leu Leu Ile His Tyr Gln Gln Asn Gln Ala Ser Cys 
    50                  55                  60                  


Gly Lys Arg Ala Ile Ile Leu Glu Thr Arg Gln His Arg Leu Phe Cys 
65                  70                  75                  80  


Ala Asp Pro Lys Glu Gln Trp Val Lys Asp Ala Met Gln His Leu Asp 
                85                  90                  95      


Arg Gln Ala Ala Ala Leu Thr Arg Asn Gly Gly Thr Phe Glu Lys Gln 
            100                 105                 110         


Ile Gly Glu Val Lys Pro Arg Thr Thr Pro Ala Ala Gly Gly Met Asp 
        115                 120                 125             


Glu Ser Val Val Leu Glu Pro Glu Ala Thr Gly Glu Ser Ser Ser Leu 
    130                 135                 140                 


Glu Pro Thr Pro Ser Ser Gln Glu Ala Gln Arg Ala Leu Gly Thr Ser 
145                 150                 155                 160 


Pro Glu Leu Pro Thr Gly Val Thr Gly Ser Ser Gly Thr Arg Leu Pro 
                165                 170                 175     


Pro Thr Pro Lys Ala Gln Asp Gly Gly Pro Val Gly Thr Glu Leu Phe 
            180                 185                 190         


Arg Val Pro Pro Val Ser Thr Ala Ala Thr Trp Gln Ser Ser Ala Pro 
        195                 200                 205             


His Gln Pro Gly Pro Ser Leu Trp Ala Glu Ala Lys Thr Ser Glu Ala 
    210                 215                 220                 


Pro Ser Thr Gln Asp Pro Ser Thr Gln Ala Ser Thr Ala Ser Ser Pro 
225                 230                 235                 240 


Ala Pro Glu Glu Asn Ala Pro Ser Glu Gly Gln Arg Val Trp Gly Gln 
                245                 250                 255     


Gly Gln Ser Pro Arg Pro Glu Asn Ser Leu Glu Arg Glu Glu Met Gly 
            260                 265                 270         


Pro Val Pro Ala His Thr Asp Ala Phe Gln Asp Trp Gly Pro Gly Ser 
        275                 280                 285             


Met Ala His Val Ser Val Val Pro Val Ser Ser Glu Gly Thr Pro Ser 
    290                 295                 300                 


Arg Glu Pro Val Ala Ser Gly Ser Trp Thr Pro Lys Ala Glu Glu Pro 
305                 310                 315                 320 


Ile His Ala Thr Met Asp Pro Gln Arg Leu Gly Val Leu Ile Thr Pro 
                325                 330                 335     


Val Pro Asp Ala Gln Ala Ala Thr Arg Arg Gln Ala Val Gly Leu Leu 
            340                 345                 350         


Ala Phe Leu Gly Leu Leu Phe Cys Leu Gly Val Ala Met Phe Thr Tyr 
        355                 360                 365             


Gln Ser Leu Gln Gly Cys Pro Arg Lys Met Ala Gly Glu Met Ala Glu 
    370                 375                 380                 


Gly Leu Arg Tyr Ile Pro Arg Ser Cys Gly Ser Asn Ser Tyr Val Leu 
385                 390                 395                 400 


Val Pro Val 
            


<210>  3789
<211>  359
<212>  PRT
<213>  Homo Sapiens

<400>  3789

Met Thr Ser Lys Ile Pro Val Ala Leu Leu Ile His Tyr Gln Gln Asn 
1               5                   10                  15      


Gln Ala Ser Cys Gly Lys Arg Ala Ile Ile Leu Glu Thr Arg Gln His 
            20                  25                  30          


Arg Leu Phe Cys Ala Asp Pro Lys Glu Gln Trp Val Lys Asp Ala Met 
        35                  40                  45              


Gln His Leu Asp Arg Gln Ala Ala Ala Leu Thr Arg Asn Gly Gly Thr 
    50                  55                  60                  


Phe Glu Lys Gln Ile Gly Glu Val Lys Pro Arg Thr Thr Pro Ala Ala 
65                  70                  75                  80  


Gly Gly Met Asp Glu Ser Val Val Leu Glu Pro Glu Ala Thr Gly Glu 
                85                  90                  95      


Ser Ser Ser Leu Glu Pro Thr Pro Ser Ser Gln Glu Ala Gln Arg Ala 
            100                 105                 110         


Leu Gly Thr Ser Pro Glu Leu Pro Thr Gly Val Thr Gly Ser Ser Gly 
        115                 120                 125             


Thr Arg Leu Pro Pro Thr Pro Lys Ala Gln Asp Gly Gly Pro Val Gly 
    130                 135                 140                 


Thr Glu Leu Phe Arg Val Pro Pro Val Ser Thr Ala Ala Thr Trp Gln 
145                 150                 155                 160 


Ser Ser Ala Pro His Gln Pro Gly Pro Ser Leu Trp Ala Glu Ala Lys 
                165                 170                 175     


Thr Ser Glu Ala Pro Ser Thr Gln Asp Pro Ser Thr Gln Ala Ser Thr 
            180                 185                 190         


Ala Ser Ser Pro Ala Pro Glu Glu Asn Ala Pro Ser Glu Gly Gln Arg 
        195                 200                 205             


Val Trp Gly Gln Gly Gln Ser Pro Arg Pro Glu Asn Ser Leu Glu Arg 
    210                 215                 220                 


Glu Glu Met Gly Pro Val Pro Ala His Thr Asp Ala Phe Gln Asp Trp 
225                 230                 235                 240 


Gly Pro Gly Ser Met Ala His Val Ser Val Val Pro Val Ser Ser Glu 
                245                 250                 255     


Gly Thr Pro Ser Arg Glu Pro Val Ala Ser Gly Ser Trp Thr Pro Lys 
            260                 265                 270         


Ala Glu Glu Pro Ile His Ala Thr Met Asp Pro Gln Arg Leu Gly Val 
        275                 280                 285             


Leu Ile Thr Pro Val Pro Asp Ala Gln Ala Ala Thr Arg Arg Gln Ala 
    290                 295                 300                 


Val Gly Leu Leu Ala Phe Leu Gly Leu Leu Phe Cys Leu Gly Val Ala 
305                 310                 315                 320 


Met Phe Thr Tyr Gln Ser Leu Gln Gly Cys Pro Arg Lys Met Ala Gly 
                325                 330                 335     


Glu Met Ala Glu Gly Leu Arg Tyr Ile Pro Arg Ser Cys Gly Ser Asn 
            340                 345                 350         


Ser Tyr Val Leu Val Pro Val 
        355                 


<210>  3790
<211>  89
<212>  PRT
<213>  Homo Sapiens

<400>  3790

Met Ala Leu Leu Leu Cys Phe Val Leu Leu Cys Gly Val Val Asp Phe 
1               5                   10                  15      


Ala Arg Ser Leu Ser Ile Thr Thr Pro Glu Glu Met Ile Glu Lys Ala 
            20                  25                  30          


Lys Gly Glu Thr Ala Tyr Leu Pro Cys Lys Phe Thr Leu Ser Pro Glu 
        35                  40                  45              


Asp Gln Gly Pro Leu Asp Ile Glu Trp Leu Ile Ser Pro Ala Asp Asn 
    50                  55                  60                  


Gln Lys Val Asp Gln Val Gly Arg Cys Ala Thr Ser Lys Glu Pro Tyr 
65                  70                  75                  80  


Val His Cys Gln Lys Leu His Arg Gln 
                85                  


<210>  3791
<211>  200
<212>  PRT
<213>  Homo Sapiens

<400>  3791

Met Ala Leu Leu Leu Cys Phe Val Leu Leu Cys Gly Val Val Asp Phe 
1               5                   10                  15      


Ala Arg Ser Leu Ser Ile Thr Thr Pro Glu Glu Met Ile Glu Lys Ala 
            20                  25                  30          


Lys Gly Glu Thr Ala Tyr Leu Pro Cys Lys Phe Thr Leu Ser Pro Glu 
        35                  40                  45              


Asp Gln Gly Pro Leu Asp Ile Glu Trp Leu Ile Ser Pro Ala Asp Asn 
    50                  55                  60                  


Gln Lys Val Asp Gln Val Ile Ile Leu Tyr Ser Gly Asp Lys Ile Tyr 
65                  70                  75                  80  


Asp Asp Tyr Tyr Pro Asp Leu Lys Gly Arg Val His Phe Thr Ser Asn 
                85                  90                  95      


Asp Leu Lys Ser Gly Asp Ala Ser Ile Asn Val Thr Asn Leu Gln Leu 
            100                 105                 110         


Ser Asp Ile Gly Thr Tyr Gln Cys Lys Val Lys Lys Ala Pro Gly Val 
        115                 120                 125             


Ala Asn Lys Lys Ile His Leu Val Val Leu Gly Lys Met Cys His Leu 
    130                 135                 140                 


Gln Arg Ala Val Arg Pro Leu Pro Glu Ala Thr Ser Ala Val Ile Ile 
145                 150                 155                 160 


His Pro Trp Gly Pro Cys Leu Leu Pro Thr Trp Lys Asp Ile Pro Arg 
                165                 170                 175     


Leu Ser Ile Thr Lys Tyr Gln Val Lys Thr Leu Asn Ala Leu Leu Arg 
            180                 185                 190         


Val Arg Leu Ser His Leu Leu Arg 
        195                 200 


<210>  3792
<211>  365
<212>  PRT
<213>  Homo Sapiens

<400>  3792

Met Ala Leu Leu Leu Cys Phe Val Leu Leu Cys Gly Val Val Asp Phe 
1               5                   10                  15      


Ala Arg Ser Leu Ser Ile Thr Thr Pro Glu Glu Met Ile Glu Lys Ala 
            20                  25                  30          


Lys Gly Glu Thr Ala Tyr Leu Pro Cys Lys Phe Thr Leu Ser Pro Glu 
        35                  40                  45              


Asp Gln Gly Pro Leu Asp Ile Glu Trp Leu Ile Ser Pro Ala Asp Asn 
    50                  55                  60                  


Gln Lys Val Asp Gln Val Ile Ile Leu Tyr Ser Gly Asp Lys Ile Tyr 
65                  70                  75                  80  


Asp Asp Tyr Tyr Pro Asp Leu Lys Gly Arg Val His Phe Thr Ser Asn 
                85                  90                  95      


Asp Leu Lys Ser Gly Asp Ala Ser Ile Asn Val Thr Asn Leu Gln Leu 
            100                 105                 110         


Ser Asp Ile Gly Thr Tyr Gln Cys Lys Val Lys Lys Ala Pro Gly Val 
        115                 120                 125             


Ala Asn Lys Lys Ile His Leu Val Val Leu Val Lys Pro Ser Gly Ala 
    130                 135                 140                 


Arg Cys Tyr Val Asp Gly Ser Glu Glu Ile Gly Ser Asp Phe Lys Ile 
145                 150                 155                 160 


Lys Cys Glu Pro Lys Glu Gly Ser Leu Pro Leu Gln Tyr Glu Trp Gln 
                165                 170                 175     


Lys Leu Ser Asp Ser Gln Lys Met Pro Thr Ser Trp Leu Ala Glu Met 
            180                 185                 190         


Thr Ser Ser Val Ile Ser Val Lys Asn Ala Ser Ser Glu Tyr Ser Gly 
        195                 200                 205             


Thr Tyr Ser Cys Thr Val Arg Asn Arg Val Gly Ser Asp Gln Cys Leu 
    210                 215                 220                 


Leu Arg Leu Asn Val Val Pro Pro Ser Asn Lys Ala Gly Leu Ile Ala 
225                 230                 235                 240 


Gly Ala Ile Ile Gly Thr Leu Leu Ala Leu Ala Leu Ile Gly Leu Ile 
                245                 250                 255     


Ile Phe Cys Cys Arg Lys Lys Arg Arg Glu Glu Lys Tyr Glu Lys Glu 
            260                 265                 270         


Val His His Asp Ile Arg Glu Asp Val Pro Pro Pro Lys Ser Arg Thr 
        275                 280                 285             


Ser Thr Ala Arg Ser Tyr Ile Gly Ser Asn His Ser Ser Leu Gly Ser 
    290                 295                 300                 


Met Ser Pro Ser Asn Met Glu Gly Tyr Ser Lys Thr Gln Tyr Asn Gln 
305                 310                 315                 320 


Val Pro Ser Glu Asp Phe Glu Arg Thr Pro Gln Ser Pro Thr Leu Pro 
                325                 330                 335     


Pro Ala Lys Val Ala Ala Pro Asn Leu Ser Arg Met Gly Ala Ile Pro 
            340                 345                 350         


Val Met Ile Pro Ala Gln Ser Lys Asp Gly Ser Ile Val 
        355                 360                 365 


<210>  3793
<211>  352
<212>  PRT
<213>  Homo Sapiens

<400>  3793

Met Ala Leu Leu Leu Cys Phe Val Leu Leu Cys Gly Val Val Asp Phe 
1               5                   10                  15      


Ala Arg Ser Leu Ser Ile Thr Thr Pro Glu Glu Met Ile Glu Lys Ala 
            20                  25                  30          


Lys Gly Glu Thr Ala Tyr Leu Pro Cys Lys Phe Thr Leu Ser Pro Glu 
        35                  40                  45              


Asp Gln Gly Pro Leu Asp Ile Glu Trp Leu Ile Ser Pro Ala Asp Asn 
    50                  55                  60                  


Gln Lys Val Asp Gln Val Ile Ile Leu Tyr Ser Gly Asp Lys Ile Tyr 
65                  70                  75                  80  


Asp Asp Tyr Tyr Pro Asp Leu Lys Gly Arg Val His Phe Thr Ser Asn 
                85                  90                  95      


Asp Leu Lys Ser Gly Asp Ala Ser Ile Asn Val Thr Asn Leu Gln Leu 
            100                 105                 110         


Ser Asp Ile Gly Thr Tyr Gln Cys Lys Val Lys Lys Ala Pro Gly Val 
        115                 120                 125             


Ala Asn Lys Lys Ile His Leu Val Val Leu Val Lys Pro Ser Gly Ala 
    130                 135                 140                 


Arg Cys Tyr Val Asp Gly Ser Glu Glu Ile Gly Ser Asp Phe Lys Ile 
145                 150                 155                 160 


Lys Cys Glu Pro Lys Glu Gly Ser Leu Pro Leu Gln Tyr Glu Trp Gln 
                165                 170                 175     


Lys Leu Ser Asp Ser Gln Lys Met Pro Thr Ser Trp Leu Ala Glu Met 
            180                 185                 190         


Thr Ser Ser Val Ile Ser Val Lys Asn Ala Ser Ser Glu Tyr Ser Gly 
        195                 200                 205             


Thr Tyr Ser Cys Thr Val Arg Asn Arg Val Gly Ser Asp Gln Cys Leu 
    210                 215                 220                 


Leu Arg Leu Asn Val Val Pro Pro Ser Asn Lys Ala Gly Leu Ile Ala 
225                 230                 235                 240 


Gly Ala Ile Ile Gly Thr Leu Leu Ala Leu Ala Leu Ile Gly Leu Ile 
                245                 250                 255     


Ile Phe Cys Cys Arg Lys Lys Arg Arg Glu Glu Lys Tyr Glu Lys Glu 
            260                 265                 270         


Val His His Asp Ile Arg Glu Asp Val Pro Pro Pro Lys Ser Arg Thr 
        275                 280                 285             


Ser Thr Ala Arg Ser Tyr Ile Gly Ser Asn His Ser Ser Leu Gly Ser 
    290                 295                 300                 


Met Ser Pro Ser Asn Met Glu Gly Tyr Ser Lys Thr Gln Tyr Asn Gln 
305                 310                 315                 320 


Val Pro Ser Glu Asp Phe Glu Arg Thr Pro Gln Ser Pro Thr Leu Pro 
                325                 330                 335     


Pro Ala Lys Phe Lys Tyr Pro Tyr Lys Thr Asp Gly Ile Thr Val Val 
            340                 345                 350         


<210>  3794
<211>  252
<212>  PRT
<213>  Homo Sapiens

<400>  3794

Met Ala Leu Leu Leu Cys Phe Val Leu Leu Cys Gly Val Val Asp Phe 
1               5                   10                  15      


Ala Arg Ser Leu Ser Ile Thr Thr Pro Glu Glu Met Ile Glu Lys Ala 
            20                  25                  30          


Lys Gly Glu Thr Ala Tyr Leu Pro Cys Lys Phe Thr Leu Ser Pro Glu 
        35                  40                  45              


Asp Gln Gly Pro Leu Asp Ile Glu Trp Leu Ile Ser Pro Ala Asp Asn 
    50                  55                  60                  


Gln Lys Val Asp Gln Val Ile Ile Leu Tyr Ser Gly Asp Lys Ile Tyr 
65                  70                  75                  80  


Asp Asp Tyr Tyr Pro Asp Leu Lys Gly Arg Val His Phe Thr Ser Asn 
                85                  90                  95      


Asp Leu Lys Ser Gly Asp Ala Ser Ile Asn Val Thr Asn Leu Gln Leu 
            100                 105                 110         


Ser Asp Ile Gly Thr Tyr Gln Cys Lys Val Lys Lys Ala Pro Gly Val 
        115                 120                 125             


Ala Asn Lys Lys Ile His Leu Val Val Leu Val Lys Pro Ser Gly Ala 
    130                 135                 140                 


Arg Cys Tyr Val Asp Gly Ser Glu Glu Ile Gly Ser Asp Phe Lys Ile 
145                 150                 155                 160 


Lys Cys Glu Pro Lys Glu Gly Ser Leu Pro Leu Gln Tyr Glu Trp Gln 
                165                 170                 175     


Lys Leu Ser Asp Ser Gln Lys Met Pro Thr Ser Trp Leu Ala Gly Lys 
            180                 185                 190         


Met Cys His Leu Gln Arg Ala Val Arg Pro Leu Pro Glu Ala Thr Ser 
        195                 200                 205             


Ala Val Ile Ile His Pro Trp Gly Pro Cys Leu Leu Pro Thr Trp Lys 
    210                 215                 220                 


Asp Ile Pro Arg Leu Ser Ile Thr Lys Tyr Gln Val Lys Thr Leu Asn 
225                 230                 235                 240 


Ala Leu Leu Arg Val Arg Leu Ser His Leu Leu Arg 
                245                 250         


<210>  3795
<211>  107
<212>  PRT
<213>  Homo Sapiens

<400>  3795

Met Ala Arg Ala Ala Leu Ser Ala Ala Pro Ser Asn Pro Arg Leu Leu 
1               5                   10                  15      


Arg Val Ala Leu Leu Leu Leu Leu Leu Val Ala Ala Gly Arg Arg Ala 
            20                  25                  30          


Ala Gly Ala Ser Val Ala Thr Glu Leu Arg Cys Gln Cys Leu Gln Thr 
        35                  40                  45              


Leu Gln Gly Ile His Pro Lys Asn Ile Gln Ser Val Asn Val Lys Ser 
    50                  55                  60                  


Pro Gly Pro His Cys Ala Gln Thr Glu Val Ile Ala Thr Leu Lys Asn 
65                  70                  75                  80  


Gly Arg Lys Ala Cys Leu Asn Pro Ala Ser Pro Ile Val Lys Lys Ile 
                85                  90                  95      


Ile Glu Lys Met Leu Asn Ser Asp Lys Ser Asn 
            100                 105         


<210>  3796
<211>  98
<212>  PRT
<213>  Homo Sapiens

<400>  3796

Met Asn Gln Thr Ala Ile Leu Ile Cys Cys Leu Ile Phe Leu Thr Leu 
1               5                   10                  15      


Ser Gly Ile Gln Gly Val Pro Leu Ser Arg Thr Val Arg Cys Thr Cys 
            20                  25                  30          


Ile Ser Ile Ser Asn Gln Pro Val Asn Pro Arg Ser Leu Glu Lys Leu 
        35                  40                  45              


Glu Ile Ile Pro Ala Ser Gln Phe Cys Pro Arg Val Glu Ile Ile Ala 
    50                  55                  60                  


Thr Met Lys Lys Lys Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser Lys 
65                  70                  75                  80  


Ala Ile Lys Asn Leu Leu Lys Ala Val Ser Lys Glu Arg Ser Lys Arg 
                85                  90                  95      


Ser Pro 
        


<210>  3797
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  3797

Met Ser Val Lys Gly Met Ala Ile Ala Leu Ala Val Ile Leu Cys Ala 
1               5                   10                  15      


Thr Val Val Gln Gly Phe Pro Met Phe Lys Arg Gly Arg Cys Leu Cys 
            20                  25                  30          


Ile Gly Pro Gly Val Lys Ala Val Lys Val Ala Asp Ile Glu Lys Ala 
        35                  40                  45              


Ser Ile Met Tyr Pro Ser Asn Asn Cys Asp Lys Ile Glu Val Ile Ile 
    50                  55                  60                  


Thr Leu Lys Glu Asn Lys Gly Gln Arg Cys Leu Asn Pro Lys Ser Lys 
65                  70                  75                  80  


Gln Ala Arg Leu Ile Ile Lys Lys Val Glu Arg Lys Asn Phe 
                85                  90                  


<210>  3798
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  3798

Met Ser Val Lys Gly Met Ala Ile Ala Leu Ala Val Ile Leu Cys Ala 
1               5                   10                  15      


Thr Val Val Gln Gly Phe Pro Met Phe Lys Arg Gly Arg Cys Leu Cys 
            20                  25                  30          


Ile Gly Pro Gly Val Lys Ala Val Lys Val Ala Asp Ile Glu Lys Ala 
        35                  40                  45              


Ser Ile Met Tyr Pro Ser Asn Asn Cys Asp Lys Ile Glu Val Ile Ile 
    50                  55                  60                  


Thr Leu Lys Glu Asn Lys Gly Gln Arg Cys Leu Asn Pro Lys Ser Lys 
65                  70                  75                  80  


Gln Ala Arg Leu Ile Ile Lys Lys Val Glu Arg Lys Asn Phe 
                85                  90                  


<210>  3799
<211>  89
<212>  PRT
<213>  Homo Sapiens

<400>  3799

Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Thr Ala Leu 
1               5                   10                  15      


Cys Leu Ser Asp Gly Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys 
            20                  25                  30          


Arg Phe Phe Glu Ser His Val Ala Arg Ala Asn Val Lys His Leu Lys 
        35                  40                  45              


Ile Leu Asn Thr Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys 
    50                  55                  60                  


Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln 
65                  70                  75                  80  


Glu Tyr Leu Glu Lys Ala Leu Asn Lys 
                85                  


<210>  3800
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  3800

Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Thr Ala Leu 
1               5                   10                  15      


Cys Leu Ser Asp Gly Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys 
            20                  25                  30          


Arg Phe Phe Glu Ser His Val Ala Arg Ala Asn Val Lys His Leu Lys 
        35                  40                  45              


Ile Leu Asn Thr Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys 
    50                  55                  60                  


Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln 
65                  70                  75                  80  


Glu Tyr Leu Glu Lys Ala Leu Asn Lys Gly Arg Arg Glu Glu Lys Val 
                85                  90                  95      


Gly Lys Lys Glu Lys Ile Gly Lys Lys Lys Arg Gln Lys Lys Arg Lys 
            100                 105                 110         


Ala Ala Gln Lys Arg Lys Asn 
        115                 


<210>  3801
<211>  93
<212>  PRT
<213>  Homo Sapiens

<400>  3801

Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Thr Ala Leu 
1               5                   10                  15      


Cys Leu Ser Asp Gly Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys 
            20                  25                  30          


Arg Phe Phe Glu Ser His Val Ala Arg Ala Asn Val Lys His Leu Lys 
        35                  40                  45              


Ile Leu Asn Thr Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys 
    50                  55                  60                  


Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln 
65                  70                  75                  80  


Glu Tyr Leu Glu Lys Ala Leu Asn Lys Arg Phe Lys Met 
                85                  90              


<210>  3802
<211>  140
<212>  PRT
<213>  Homo Sapiens

<400>  3802

Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Thr Ala Leu 
1               5                   10                  15      


Cys Leu Ser Asp Gly Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys 
            20                  25                  30          


Arg Phe Phe Glu Ser His Val Ala Arg Ala Asn Val Lys His Leu Lys 
        35                  40                  45              


Ile Leu Asn Thr Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys 
    50                  55                  60                  


Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln 
65                  70                  75                  80  


Glu Tyr Leu Glu Lys Ala Leu Asn Asn Leu Ile Ser Ala Ala Pro Ala 
                85                  90                  95      


Gly Lys Arg Val Ile Ala Gly Ala Arg Ala Leu His Pro Ser Pro Pro 
            100                 105                 110         


Arg Ala Cys Pro Thr Ala Arg Ala Leu Cys Glu Ile Arg Leu Trp Pro 
        115                 120                 125             


Pro Pro Glu Trp Ser Trp Pro Ser Pro Gly Asp Val 
    130                 135                 140 


<210>  3803
<211>  103
<212>  PRT
<213>  Homo Sapiens

<400>  3803

Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Thr Ala Leu 
1               5                   10                  15      


Cys Leu Ser Asp Gly Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys 
            20                  25                  30          


Arg Phe Phe Glu Ser His Tyr Cys Thr Cys Leu Ile Arg Val Ser Phe 
        35                  40                  45              


His Gly Ala Thr Pro Leu Thr Gln Gly Ser Trp Val Leu Tyr Ser Leu 
    50                  55                  60                  


Ser Cys Ala Gly Gly Glu Thr Gly Leu Arg Glu Pro Gly Pro Met Val 
65                  70                  75                  80  


Ser Pro Arg Val Glu Ser His Gln Glu Gly Arg Leu Gly Val Pro Gly 
                85                  90                  95      


Pro Val Asn Leu Gly Lys Ala 
            100             


<210>  3804
<211>  103
<212>  PRT
<213>  Homo Sapiens

<400>  3804

Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Thr Ala Leu 
1               5                   10                  15      


Cys Leu Ser Asp Gly Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys 
            20                  25                  30          


Arg Phe Phe Glu Ser His Tyr Cys Thr Cys Leu Ile Arg Val Ser Phe 
        35                  40                  45              


His Gly Ala Thr Pro Leu Thr Gln Gly Ser Trp Val Leu Tyr Ser Leu 
    50                  55                  60                  


Ser Cys Ala Gly Gly Glu Thr Gly Leu Arg Glu Pro Gly Pro Met Val 
65                  70                  75                  80  


Ser Pro Arg Val Glu Ser His Gln Glu Gly Arg Leu Gly Val Pro Gly 
                85                  90                  95      


Pro Val Asn Leu Gly Lys Ala 
            100             


<210>  3805
<211>  109
<212>  PRT
<213>  Homo Sapiens

<400>  3805

Met Lys Phe Ile Ser Thr Ser Leu Leu Leu Met Leu Leu Val Ser Ser 
1               5                   10                  15      


Leu Ser Pro Val Gln Gly Val Leu Glu Val Tyr Tyr Thr Ser Leu Arg 
            20                  25                  30          


Cys Arg Cys Val Gln Glu Ser Ser Val Phe Ile Pro Arg Arg Phe Ile 
        35                  40                  45              


Asp Arg Ile Gln Ile Leu Pro Arg Gly Asn Gly Cys Pro Arg Lys Glu 
    50                  55                  60                  


Ile Ile Val Trp Lys Lys Asn Lys Ser Ile Val Cys Val Asp Pro Gln 
65                  70                  75                  80  


Ala Glu Trp Ile Gln Arg Met Met Glu Val Leu Arg Lys Arg Ser Ser 
                85                  90                  95      


Ser Thr Leu Pro Val Pro Val Phe Lys Arg Lys Ile Pro 
            100                 105                 


<210>  3806
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  3806

Met Arg Leu Leu Ala Ala Ala Leu Leu Leu Leu Leu Leu Ala Leu Tyr 
1               5                   10                  15      


Thr Ala Arg Val Asp Gly Ser Lys Cys Lys Cys Ser Arg Lys Gly Pro 
            20                  25                  30          


Lys Ile Arg Tyr Ser Asp Val Lys Lys Leu Glu Met Lys Pro Lys Tyr 
        35                  40                  45              


Pro His Cys Glu Glu Lys Met Val Ile Ile Thr Thr Lys Ser Val Ser 
    50                  55                  60                  


Arg Tyr Arg Gly Gln Glu His Cys Leu His Pro Lys Leu Gln Ser Thr 
65                  70                  75                  80  


Lys Arg Phe Ile Lys Trp Tyr Asn Ala Trp Asn Glu Lys Arg Arg Val 
                85                  90                  95      


Tyr Glu Glu 
            


<210>  3807
<211>  111
<212>  PRT
<213>  Homo Sapiens

<400>  3807

Met Ser Leu Leu Pro Arg Arg Ala Pro Pro Val Ser Met Arg Leu Leu 
1               5                   10                  15      


Ala Ala Ala Leu Leu Leu Leu Leu Leu Ala Leu Tyr Thr Ala Arg Val 
            20                  25                  30          


Asp Gly Ser Lys Cys Lys Cys Ser Arg Lys Gly Pro Lys Ile Arg Tyr 
        35                  40                  45              


Ser Asp Val Lys Lys Leu Glu Met Lys Pro Lys Tyr Pro His Cys Glu 
    50                  55                  60                  


Glu Lys Met Val Ile Ile Thr Thr Lys Ser Val Ser Arg Tyr Arg Gly 
65                  70                  75                  80  


Gln Glu His Cys Leu His Pro Lys Leu Gln Ser Thr Lys Arg Phe Ile 
                85                  90                  95      


Lys Trp Tyr Asn Ala Trp Asn Glu Lys Arg Arg Val Tyr Glu Glu 
            100                 105                 110     


<210>  3808
<211>  62
<212>  PRT
<213>  Homo Sapiens

<400>  3808

Met Lys Val Leu Ile Ser Ser Leu Leu Leu Leu Leu Pro Leu Met Leu 
1               5                   10                  15      


Met Ser Met Val Ser Ser Ser Leu Asn Pro Gly Val Ala Arg Gly His 
            20                  25                  30          


Arg Asp Arg Gly Gln Ala Ser Arg Arg Trp Leu Gln Glu Gly Gly Gln 
        35                  40                  45              


Glu Cys Glu Cys Lys Ala Met Leu Leu Phe Gln Ile Gly Ser 
    50                  55                  60          


<210>  3809
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  3809

Met Lys Val Leu Ile Ser Ser Leu Leu Leu Leu Leu Pro Leu Met Leu 
1               5                   10                  15      


Met Ser Met Val Ser Ser Ser Leu Asn Pro Gly Val Ala Arg Gly His 
            20                  25                  30          


Arg Asp Arg Gly Gln Ala Ser Arg Arg Trp Leu Gln Glu Gly Gly Gln 
        35                  40                  45              


Glu Cys Glu Cys Lys Asp Trp Phe Leu Arg Ala Pro Arg Arg Lys Phe 
    50                  55                  60                  


Met Thr Val Ser Gly Leu Pro Lys Lys Gln Cys Pro Cys Asp His Phe 
65                  70                  75                  80  


Lys Gly Asn Val Lys Lys Thr Arg His Gln Arg His His Arg Lys Pro 
                85                  90                  95      


Asn Lys His Ser Arg Ala Cys Gln Gln Phe Leu Lys Gln Cys Gln Leu 
            100                 105                 110         


Arg Ser Phe Ala Leu Pro Leu 
        115                 


<210>  3810
<211>  107
<212>  PRT
<213>  Homo Sapiens

<400>  3810

Met Ala Arg Ala Thr Leu Ser Ala Ala Pro Ser Asn Pro Arg Leu Leu 
1               5                   10                  15      


Arg Val Ala Leu Leu Leu Leu Leu Leu Val Ala Ala Ser Arg Arg Ala 
            20                  25                  30          


Ala Gly Ala Pro Leu Ala Thr Glu Leu Arg Cys Gln Cys Leu Gln Thr 
        35                  40                  45              


Leu Gln Gly Ile His Leu Lys Asn Ile Gln Ser Val Lys Val Lys Ser 
    50                  55                  60                  


Pro Gly Pro His Cys Ala Gln Thr Glu Val Ile Ala Thr Leu Lys Asn 
65                  70                  75                  80  


Gly Gln Lys Ala Cys Leu Asn Pro Ala Ser Pro Met Val Lys Lys Ile 
                85                  90                  95      


Ile Glu Lys Met Leu Lys Asn Gly Lys Ser Asn 
            100                 105         


<210>  3811
<211>  107
<212>  PRT
<213>  Homo Sapiens

<400>  3811

Met Ala His Ala Thr Leu Ser Ala Ala Pro Ser Asn Pro Arg Leu Leu 
1               5                   10                  15      


Arg Val Ala Leu Leu Leu Leu Leu Leu Val Ala Ala Ser Arg Arg Ala 
            20                  25                  30          


Ala Gly Ala Ser Val Val Thr Glu Leu Arg Cys Gln Cys Leu Gln Thr 
        35                  40                  45              


Leu Gln Gly Ile His Leu Lys Asn Ile Gln Ser Val Asn Val Arg Ser 
    50                  55                  60                  


Pro Gly Pro His Cys Ala Gln Thr Glu Val Ile Ala Thr Leu Lys Asn 
65                  70                  75                  80  


Gly Lys Lys Ala Cys Leu Asn Pro Ala Ser Pro Met Val Gln Lys Ile 
                85                  90                  95      


Ile Glu Lys Ile Leu Asn Lys Gly Ser Thr Asn 
            100                 105         


<210>  3812
<211>  114
<212>  PRT
<213>  Homo Sapiens

<400>  3812

Met Ser Leu Leu Ser Ser Arg Ala Ala Arg Val Pro Gly Pro Ser Ser 
1               5                   10                  15      


Ser Leu Cys Ala Leu Leu Val Leu Leu Leu Leu Leu Thr Gln Pro Gly 
            20                  25                  30          


Pro Ile Ala Ser Ala Gly Pro Ala Ala Ala Val Leu Arg Glu Leu Arg 
        35                  40                  45              


Cys Val Cys Leu Gln Thr Thr Gln Gly Val His Pro Lys Met Ile Ser 
    50                  55                  60                  


Asn Leu Gln Val Phe Ala Ile Gly Pro Gln Cys Ser Lys Val Glu Val 
65                  70                  75                  80  


Val Ala Ser Leu Lys Asn Gly Lys Glu Ile Cys Leu Asp Pro Glu Ala 
                85                  90                  95      


Pro Phe Leu Lys Lys Val Ile Gln Lys Ile Leu Asp Gly Gly Asn Lys 
            100                 105                 110         


Glu Asn 
        


<210>  3813
<211>  113
<212>  PRT
<213>  Homo Sapiens

<400>  3813

Met Ser Leu Pro Ser Ser Arg Ala Ala Arg Val Pro Gly Pro Ser Gly 
1               5                   10                  15      


Ser Leu Cys Ala Leu Leu Ala Leu Leu Leu Leu Leu Thr Pro Pro Gly 
            20                  25                  30          


Pro Leu Ala Ser Ala Gly Pro Val Ser Ala Val Leu Thr Glu Leu Arg 
        35                  40                  45              


Cys Thr Cys Leu Arg Val Thr Leu Arg Val Asn Pro Lys Thr Ile Gly 
    50                  55                  60                  


Lys Leu Gln Val Phe Pro Ala Gly Pro Gln Cys Ser Lys Val Glu Val 
65                  70                  75                  80  


Val Ala Ser Leu Lys Asn Gly Lys Gln Val Cys Leu Asp Pro Glu Ala 
                85                  90                  95      


Pro Phe Leu Lys Lys Val Ile Gln Lys Ile Leu Asp Arg Tyr Leu Ser 
            100                 105                 110         


Leu 
    


<210>  3814
<211>  114
<212>  PRT
<213>  Homo Sapiens

<400>  3814

Met Ser Leu Pro Ser Ser Arg Ala Ala Arg Val Pro Gly Pro Ser Gly 
1               5                   10                  15      


Ser Leu Cys Ala Leu Leu Ala Leu Leu Leu Leu Leu Thr Pro Pro Gly 
            20                  25                  30          


Pro Leu Ala Ser Ala Gly Pro Val Ser Ala Val Leu Thr Glu Leu Arg 
        35                  40                  45              


Cys Thr Cys Leu Arg Val Thr Leu Arg Val Asn Pro Lys Thr Ile Gly 
    50                  55                  60                  


Lys Leu Gln Val Phe Pro Ala Gly Pro Gln Cys Ser Lys Val Glu Val 
65                  70                  75                  80  


Val Ala Ser Leu Lys Asn Gly Lys Gln Val Cys Leu Asp Pro Glu Ala 
                85                  90                  95      


Pro Phe Leu Lys Lys Val Ile Gln Lys Ile Leu Asp Ser Gly Asn Lys 
            100                 105                 110         


Lys Asn 
        


<210>  3815
<211>  95
<212>  PRT
<213>  Homo Sapiens

<400>  3815

Met Thr Ser Lys Leu Ala Val Ala Leu Leu Ala Ala Phe Leu Ile Ser 
1               5                   10                  15      


Ala Ala Leu Cys Glu Gly Ala Val Leu Pro Arg Ser Ala Lys Glu Leu 
            20                  25                  30          


Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys Pro Phe His Pro Lys Phe 
        35                  40                  45              


Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys Ala Asn Thr 
    50                  55                  60                  


Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu Asp Pro 
65                  70                  75                  80  


Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys Phe Leu Lys Arg 
                85                  90                  95  


<210>  3816
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  3816

Met Thr Ser Lys Leu Ala Val Ala Leu Leu Ala Ala Phe Leu Ile Ser 
1               5                   10                  15      


Ala Ala Leu Cys Glu Gly Ala Val Leu Pro Arg Ser Ala Lys Glu Leu 
            20                  25                  30          


Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys Pro Phe His Pro Lys Phe 
        35                  40                  45              


Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys Ala Asn Thr 
    50                  55                  60                  


Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu Asp Pro 
65                  70                  75                  80  


Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys Phe Leu Lys Arg Ala 
                85                  90                  95      


Glu Asn Ser 
            


<210>  3817
<211>  125
<212>  PRT
<213>  Homo Sapiens

<400>  3817

Met Lys Lys Ser Gly Val Leu Phe Leu Leu Gly Ile Ile Leu Leu Val 
1               5                   10                  15      


Leu Ile Gly Val Gln Gly Thr Pro Val Val Arg Lys Gly Arg Cys Ser 
            20                  25                  30          


Cys Ile Ser Thr Asn Gln Gly Thr Ile His Leu Gln Ser Leu Lys Asp 
        35                  40                  45              


Leu Lys Gln Phe Ala Pro Ser Pro Ser Cys Glu Lys Ile Glu Ile Ile 
    50                  55                  60                  


Ala Thr Leu Lys Asn Gly Val Gln Thr Cys Leu Asn Pro Asp Ser Ala 
65                  70                  75                  80  


Asp Val Lys Glu Leu Ile Lys Lys Trp Glu Lys Gln Val Ser Gln Lys 
                85                  90                  95      


Lys Lys Gln Lys Asn Gly Lys Lys His Gln Lys Lys Lys Val Leu Lys 
            100                 105                 110         


Val Arg Lys Ser Gln Arg Ser Arg Gln Lys Lys Thr Thr 
        115                 120                 125 


<210>  3818
<211>  182
<212>  PRT
<213>  Homo Sapiens

<400>  3818

Met Glu Pro Gln Leu Gly Pro Glu Ala Ala Ala Leu Arg Pro Gly Trp 
1               5                   10                  15      


Leu Ala Leu Leu Leu Trp Val Ser Ala Leu Ser Cys Ser Phe Ser Leu 
            20                  25                  30          


Pro Ala Ser Ser Leu Ser Ser Leu Val Pro Gln Val Arg Thr Ser Tyr 
        35                  40                  45              


Asn Phe Gly Arg Thr Phe Leu Gly Leu Asp Lys Cys Asn Ala Cys Ile 
    50                  55                  60                  


Gly Thr Ser Ile Cys Lys Lys Phe Phe Lys Glu Glu Ile Arg Ser Asp 
65                  70                  75                  80  


Asn Trp Leu Ala Ser His Leu Gly Leu Pro Pro Asp Ser Leu Leu Ser 
                85                  90                  95      


Tyr Pro Ala Asn Tyr Ser Asp Asp Ser Lys Ile Trp Arg Pro Val Glu 
            100                 105                 110         


Ile Phe Arg Leu Val Ser Lys Tyr Gln Asn Glu Ile Ser Asp Arg Arg 
        115                 120                 125             


Ile Cys Ala Ser Ala Ser Ala Pro Lys Thr Cys Ser Ile Glu Arg Val 
    130                 135                 140                 


Leu Arg Lys Thr Glu Arg Phe Gln Lys Trp Leu Gln Ala Lys Arg Leu 
145                 150                 155                 160 


Thr Pro Asp Leu Val Gln Asp Cys His Gln Gly Gln Arg Glu Leu Lys 
                165                 170                 175     


Phe Leu Cys Met Leu Arg 
            180         


<210>  3819
<211>  433
<212>  PRT
<213>  Homo Sapiens

<400>  3819

Met Glu Pro Gln Leu Gly Pro Glu Ala Ala Ala Leu Arg Pro Gly Trp 
1               5                   10                  15      


Leu Ala Leu Leu Leu Trp Val Ser Ala Leu Ser Cys Ser Phe Ser Leu 
            20                  25                  30          


Pro Ala Ser Ser Leu Ser Ser Leu Val Pro Gln Val Arg Thr Ser Tyr 
        35                  40                  45              


Asn Phe Gly Arg Thr Phe Leu Gly Leu Asp Lys Cys Asn Ala Cys Ile 
    50                  55                  60                  


Gly Thr Ser Ile Cys Lys Lys Phe Phe Lys Glu Glu Ile Arg Ser Asp 
65                  70                  75                  80  


Asn Trp Leu Ala Ser His Leu Gly Leu Pro Pro Asp Ser Leu Leu Ser 
                85                  90                  95      


Tyr Pro Ala Asn Tyr Ser Asp Asp Ser Lys Ile Trp Arg Pro Val Glu 
            100                 105                 110         


Ile Phe Arg Leu Val Ser Lys Tyr Gln Asn Glu Ile Ser Asp Arg Arg 
        115                 120                 125             


Ile Cys Ala Ser Ala Ser Ala Pro Lys Thr Cys Ser Ile Glu Arg Val 
    130                 135                 140                 


Leu Arg Lys Thr Glu Arg Phe Gln Lys Trp Leu Gln Ala Lys Arg Leu 
145                 150                 155                 160 


Thr Pro Asp Leu Val Gln Gly Leu Ala Ser Pro Leu Leu Arg Cys Pro 
                165                 170                 175     


Ser Gln Arg Leu Leu Asp Arg Val Val Arg Arg Tyr Ala Glu Val Ala 
            180                 185                 190         


Asp Ala Gly Ser Ile Phe Met Asp His Phe Thr Asp Arg Asp Lys Leu 
        195                 200                 205             


Arg Leu Leu Tyr Thr Leu Ala Val Asn Ser His Pro Ile Leu Leu Gln 
    210                 215                 220                 


Ile Phe Pro Gly Ala Glu Gly Trp Pro Leu Pro Lys Tyr Leu Gly Ser 
225                 230                 235                 240 


Cys Gly Arg Phe Leu Val Ser Thr Ser Thr Arg Pro Leu Gln Glu Phe 
                245                 250                 255     


Tyr Asp Ala Pro Pro Asp Gln Ala Ala Asp Leu Ala Tyr Gln Leu Leu 
            260                 265                 270         


Gly Val Leu Glu Ser Leu Arg Ser Asn Asp Leu Asn Tyr Phe Phe Tyr 
        275                 280                 285             


Phe Thr His Ile Asp Ala Gly Met Phe Gly Val Phe Asn Asn Gly His 
    290                 295                 300                 


Leu Phe Ile Arg Asp Ala Ser Ala Val Gly Val Ile Asp Lys Gln Glu 
305                 310                 315                 320 


Gly Ser Gln Glu Ala Asn Arg Ala Gly Glu Asn Lys Asp Ile Phe Ser 
                325                 330                 335     


Cys Leu Val Ser Gly Cys Gln Ala Gln Leu Pro Ser Cys Glu Ser Ile 
            340                 345                 350         


Ser Glu Lys Gln Ser Leu Val Leu Val Cys Gln Lys Leu Leu Pro Arg 
        355                 360                 365             


Leu Leu Gln Gly Arg Phe Pro Ser Pro Val Gln Asp Asp Ile Asp Ser 
    370                 375                 380                 


Ile Leu Val Gln Cys Gly Asp Ser Ile Arg Pro Asp Pro Glu Val Leu 
385                 390                 395                 400 


Gly Ala Ala Ser Gln Leu Lys Asp Ile Leu Arg Pro Leu Arg Thr Cys 
                405                 410                 415     


Asp Ser Arg Phe Ala Tyr Arg Tyr Pro Asp Cys Lys Tyr Asn Asp Lys 
            420                 425                 430         


Phe 
    


<210>  3820
<211>  264
<212>  PRT
<213>  Homo Sapiens

<400>  3820

Met Leu Arg Cys Gly Gly Arg Gly Leu Leu Leu Gly Leu Ala Val Ala 
1               5                   10                  15      


Ala Ala Ala Val Met Ala Ala Arg Leu Met Gly Trp Trp Gly Pro Arg 
            20                  25                  30          


Ala Gly Phe Arg Leu Phe Ile Pro Glu Glu Leu Ser Arg Tyr Arg Gly 
        35                  40                  45              


Gly Pro Gly Asp Pro Gly Leu Tyr Leu Ala Leu Leu Gly Arg Val Tyr 
    50                  55                  60                  


Asp Val Ser Ser Gly Arg Arg His Tyr Glu Pro Gly Ser His Tyr Ser 
65                  70                  75                  80  


Gly Phe Ala Gly Arg Asp Ala Ser Arg Ala Phe Val Thr Gly Asp Cys 
                85                  90                  95      


Ser Glu Ala Gly Leu Val Asp Asp Val Ser Asp Leu Ser Ala Ala Glu 
            100                 105                 110         


Met Leu Thr Leu His Asn Trp Leu Ser Phe Tyr Glu Lys Asn Tyr Val 
        115                 120                 125             


Cys Val Gly Arg Val Thr Gly Arg Phe Tyr Gly Glu Asp Gly Leu Pro 
    130                 135                 140                 


Thr Pro Ala Leu Thr Gln Val Glu Ala Ala Ile Thr Arg Gly Leu Glu 
145                 150                 155                 160 


Ala Asn Lys Leu Gln Leu Gln Glu Lys Gln Thr Phe Pro Pro Cys Asn 
                165                 170                 175     


Ala Glu Trp Ser Ser Ala Arg Gly Ser Arg Leu Trp Cys Ser Gln Lys 
            180                 185                 190         


Ser Gly Gly Val Ser Arg Asp Trp Ile Gly Val Pro Arg Lys Leu Tyr 
        195                 200                 205             


Lys Pro Gly Ala Lys Glu Pro Arg Cys Val Cys Val Arg Thr Thr Gly 
    210                 215                 220                 


Pro Pro Ser Gly Gln Met Pro Asp Asn Pro Pro His Arg Asn Arg Gly 
225                 230                 235                 240 


Asp Leu Asp His Pro Asn Leu Ala Glu Tyr Thr Gly Cys Pro Pro Leu 
                245                 250                 255     


Ala Ile Thr Cys Ser Phe Pro Leu 
            260                 


<210>  3821
<211>  106
<212>  PRT
<213>  Homo Sapiens

<400>  3821

Met Leu Thr Leu His Asn Trp Leu Ser Phe Tyr Glu Lys Asn Tyr Val 
1               5                   10                  15      


Cys Val Gly Arg Val Thr Gly Arg Phe Tyr Gly Glu Asp Gly Leu Pro 
            20                  25                  30          


Thr Pro Ala Leu Thr Gln Val Glu Ala Ala Ile Thr Arg Gly Leu Glu 
        35                  40                  45              


Ala Asn Lys Leu Gln Leu Gln Glu Lys Gln Thr Phe Pro Pro Cys Asn 
    50                  55                  60                  


Ala Glu Trp Ser Ser Ala Arg Gly Ser Arg Leu Trp Cys Ser Gln Lys 
65                  70                  75                  80  


Arg Gly Phe Asn Ser Ser Leu Ala Leu Ala Ser Gly Ser Leu Lys His 
                85                  90                  95      


Ala Cys His Arg Leu Ile Leu Gln Phe Leu 
            100                 105     


<210>  3822
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  3822

Met Leu Thr Leu His Asn Trp Leu Ser Phe Tyr Glu Lys Asn Tyr Val 
1               5                   10                  15      


Cys Val Gly Arg Val Thr Gly Arg Phe Tyr Gly Glu Asp Gly Leu Pro 
            20                  25                  30          


Thr Pro Ala Leu Thr Gln Val Glu Ala Ala Ile Thr Arg Gly Leu Glu 
        35                  40                  45              


Ala Asn Lys Leu Gln Leu Gln Glu Lys Gln Thr Phe Pro Pro Cys Asn 
    50                  55                  60                  


Ala Glu Trp Ser Ser Ala Arg Gly Ser Arg Leu Trp Cys Ser Gln Lys 
65                  70                  75                  80  


Ser Gly Gly Val Ser Arg Asp Trp Ile Gly Val Pro Arg Lys Leu Tyr 
                85                  90                  95      


Lys Pro Gly Ala Lys Glu Pro Arg Cys Val Cys Val Arg Thr Thr Gly 
            100                 105                 110         


Pro Pro Ser Gly Gln Met Pro Asp Asn Pro Pro His Arg Asn Arg Gly 
        115                 120                 125             


Asp Leu Asp His Pro Asn Leu Ala Glu Tyr Thr Gly Cys Pro Pro Leu 
    130                 135                 140                 


Ala Ile Thr Cys Ser Phe Pro Leu 
145                 150         


<210>  3823
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  3823

Met Leu Thr Leu His Asn Trp Leu Ser Phe Tyr Glu Lys Asn Tyr Val 
1               5                   10                  15      


Cys Val Gly Arg Val Thr Gly Arg Phe Tyr Gly Glu Asp Gly Leu Pro 
            20                  25                  30          


Thr Pro Ala Leu Thr Gln Val Glu Ala Ala Ile Thr Arg Gly Leu Glu 
        35                  40                  45              


Ala Asn Lys Leu Gln Leu Gln Glu Lys Gln Thr Phe Pro Pro Cys Asn 
    50                  55                  60                  


Ala Glu Trp Ser Ser Ala Arg Gly Ser Arg Leu Trp Cys Ser Gln Lys 
65                  70                  75                  80  


Ser Gly Gly Val Ser Arg Asp Trp Ile Gly Val Pro Arg Lys Leu Tyr 
                85                  90                  95      


Lys Pro Gly Ala Lys Glu Pro Arg Cys Val Cys Val Arg Thr Thr Gly 
            100                 105                 110         


Pro Pro Ser Gly Gln Met Pro Asp Asn Pro Pro His Arg Asn Arg Gly 
        115                 120                 125             


Asp Leu Asp His Pro Asn Leu Ala Glu Tyr Thr Gly Cys Pro Pro Leu 
    130                 135                 140                 


Ala Ile Thr Cys Ser Phe Pro Leu 
145                 150         


<210>  3824
<211>  42
<212>  PRT
<213>  Homo Sapiens

<400>  3824

Met Ala Pro Lys Pro Gly Ala Glu Trp Ser Thr Ala Leu Ser His Leu 
1               5                   10                  15      


Val Leu Gly Val Val Ser Leu His Ala Ala Val Ser Thr Ala Glu Ala 
            20                  25                  30          


Ser Arg Gly Ala Ala Ala Gly Phe Leu Leu 
        35                  40          


<210>  3825
<211>  362
<212>  PRT
<213>  Homo Sapiens

<400>  3825

Met Ala Pro Lys Pro Gly Ala Glu Trp Ser Thr Ala Leu Ser His Leu 
1               5                   10                  15      


Val Leu Gly Val Val Ser Leu His Ala Ala Val Ser Thr Ala Glu Ala 
            20                  25                  30          


Ser Arg Gly Ala Ala Ala Gly Phe Leu Leu Gln Val Leu Ala Ala Thr 
        35                  40                  45              


Thr Thr Leu Ala Pro Gly Leu Ser Thr His Glu Asp Cys Leu Ala Gly 
    50                  55                  60                  


Ala Trp Val Ala Thr Val Ile Gly Leu Pro Leu Leu Ala Phe Asp Phe 
65                  70                  75                  80  


His Trp Cys Thr Asn Gly His Leu Met Cys Ala Gly Cys Phe Ile His 
                85                  90                  95      


Leu Leu Ala Asp Ala Arg Leu Lys Glu Glu Gln Ala Thr Cys Pro Asn 
            100                 105                 110         


Cys Arg Cys Glu Ile Ser Lys Ser Leu Cys Cys Arg Asn Leu Ala Val 
        115                 120                 125             


Glu Lys Ala Val Ser Glu Leu Pro Ser Glu Cys Gly Phe Cys Leu Arg 
    130                 135                 140                 


Gln Phe Pro Arg Ser Leu Leu Glu Arg His Gln Lys Glu Glu Cys Gln 
145                 150                 155                 160 


Asp Arg Val Thr Gln Cys Lys Tyr Lys Arg Ile Gly Cys Pro Trp His 
                165                 170                 175     


Gly Pro Phe His Glu Leu Thr Val His Glu Ala Ala Cys Ala His Pro 
            180                 185                 190         


Thr Lys Thr Gly Ser Glu Leu Met Glu Ile Leu Asp Gly Met Asp Gln 
        195                 200                 205             


Ser His Arg Lys Glu Met Gln Leu Tyr Asn Ser Ile Phe Ser Leu Leu 
    210                 215                 220                 


Ser Phe Glu Lys Ile Gly Tyr Thr Glu Val Gln Phe Arg Pro Tyr Arg 
225                 230                 235                 240 


Thr Asp Asp Phe Ile Thr Arg Leu Tyr Tyr Glu Thr Pro Arg Phe Thr 
                245                 250                 255     


Val Leu Asn Gln Thr Trp Val Leu Lys Ala Arg Val Asn Asp Ser Glu 
            260                 265                 270         


Arg Asn Pro Asn Leu Ser Cys Lys Arg Thr Leu Ser Phe Gln Leu Leu 
        275                 280                 285             


Leu Lys Ser Lys Val Thr Ala Pro Leu Glu Cys Ser Phe Leu Leu Leu 
    290                 295                 300                 


Lys Gly Pro Tyr Asp Asp Val Arg Ile Ser Pro Val Ile Tyr His Phe 
305                 310                 315                 320 


Val Phe Thr Asn Glu Ser Asn Glu Thr Asp Tyr Val Pro Leu Pro Ile 
                325                 330                 335     


Ile Asp Ser Val Glu Cys Asn Lys Leu Leu Ala Ala Lys Asn Ile Asn 
            340                 345                 350         


Leu Arg Leu Phe Leu Phe Gln Ile Gln Lys 
        355                 360         


<210>  3826
<211>  144
<212>  PRT
<213>  Homo Sapiens

<400>  3826

Met Ala Pro Lys Pro Gly Ala Glu Trp Ser Thr Ala Leu Ser His Leu 
1               5                   10                  15      


Val Leu Gly Val Val Ser Leu His Ala Ala Val Ser Thr Ala Glu Ala 
            20                  25                  30          


Ser Arg Gly Ala Ala Ala Gly Phe Leu Leu Gln Val Leu Ala Ala Thr 
        35                  40                  45              


Thr Thr Leu Ala Pro Gly Leu Ser Thr His Glu Asp Cys Leu Ala Gly 
    50                  55                  60                  


Ala Trp Val Ala Thr Val Ile Gly Leu Pro Leu Leu Ala Phe Asp Phe 
65                  70                  75                  80  


His Trp Val Asn Gly Asp Arg Ser Ser Ala Asn Leu Leu Leu Gly Gly 
                85                  90                  95      


Gly Met Val Leu Ala Val Ala Gly Gly His Leu Gly Pro Glu Gly Arg 
            100                 105                 110         


Ser Val Ala Gly Gln Ala Met Leu Leu Val Val Ala Val Thr Ile Leu 
        115                 120                 125             


Ile Val Ala Val Phe Thr Ala Asn Thr Tyr Gly Met Trp Gly Gly Ala 
    130                 135                 140                 


<210>  3827
<211>  192
<212>  PRT
<213>  Homo Sapiens

<400>  3827

Met Ala Pro Lys Pro Gly Ala Glu Trp Ser Thr Ala Leu Ser His Leu 
1               5                   10                  15      


Val Leu Gly Val Val Ser Leu His Ala Ala Val Ser Thr Ala Glu Ala 
            20                  25                  30          


Ser Arg Gly Ala Ala Ala Gly Phe Leu Leu Gln Val Leu Ala Ala Thr 
        35                  40                  45              


Thr Thr Leu Ala Pro Gly Leu Ser Thr His Glu Asp Cys Leu Ala Gly 
    50                  55                  60                  


Ala Trp Val Ala Thr Val Ile Gly Leu Pro Leu Leu Ala Phe Asp Phe 
65                  70                  75                  80  


His Trp Val Asn Gly Asp Arg Ser Ser Ala Asn Leu Leu Leu Gly Gly 
                85                  90                  95      


Gly Met Val Leu Ala Val Ala Gly Gly His Leu Gly Pro Glu Gly Arg 
            100                 105                 110         


Ser Val Ala Gly Gln Ala Met Leu Leu Val Val Ala Val Thr Ile Leu 
        115                 120                 125             


Ile Val Ala Val Phe Thr Ala Asn Thr Tyr Gly Met Trp Gly Gly Ala 
    130                 135                 140                 


Met Leu Gly Val Ala Gly Leu Leu Ser Arg Leu Glu Glu Asp Arg Leu 
145                 150                 155                 160 


Leu Leu Leu Pro Lys Glu Asp Val Cys Arg Trp Ala Leu Ala Val Gly 
                165                 170                 175     


Ser Trp Ala Tyr Cys Arg Ala Leu His Thr Gln Arg Leu Gln Trp Glu 
            180                 185                 190         


<210>  3828
<211>  192
<212>  PRT
<213>  Homo Sapiens

<400>  3828

Met Ala Pro Lys Pro Gly Ala Glu Trp Ser Thr Ala Leu Ser His Leu 
1               5                   10                  15      


Val Leu Gly Val Val Ser Leu His Ala Ala Val Ser Thr Ala Glu Ala 
            20                  25                  30          


Ser Arg Gly Ala Ala Ala Gly Phe Leu Leu Gln Val Leu Ala Ala Thr 
        35                  40                  45              


Thr Thr Leu Ala Pro Gly Leu Ser Thr His Glu Asp Cys Leu Ala Gly 
    50                  55                  60                  


Ala Trp Val Ala Thr Val Ile Gly Leu Pro Leu Leu Ala Phe Asp Phe 
65                  70                  75                  80  


His Trp Val Asn Gly Asp Arg Ser Ser Ala Asn Leu Leu Leu Gly Gly 
                85                  90                  95      


Gly Met Val Leu Ala Val Ala Gly Gly His Leu Gly Pro Glu Gly Arg 
            100                 105                 110         


Ser Val Ala Gly Gln Ala Met Leu Leu Val Val Ala Val Thr Ile Leu 
        115                 120                 125             


Ile Val Ala Val Phe Thr Ala Asn Thr Tyr Gly Met Trp Gly Gly Ala 
    130                 135                 140                 


Met Leu Gly Val Ala Gly Leu Leu Ser Arg Leu Glu Glu Asp Arg Leu 
145                 150                 155                 160 


Leu Leu Leu Pro Lys Glu Asp Val Cys Arg Trp Ala Leu Ala Val Gly 
                165                 170                 175     


Ser Trp Ala Tyr Cys Arg Ala Leu His Thr Gln Arg Leu Gln Trp Glu 
            180                 185                 190         


<210>  3829
<211>  192
<212>  PRT
<213>  Homo Sapiens

<400>  3829

Met Ala Pro Lys Pro Gly Ala Glu Trp Ser Thr Ala Leu Ser His Leu 
1               5                   10                  15      


Val Leu Gly Val Val Ser Leu His Ala Ala Val Ser Thr Ala Glu Ala 
            20                  25                  30          


Ser Arg Gly Ala Ala Ala Gly Phe Leu Leu Gln Val Leu Ala Ala Thr 
        35                  40                  45              


Thr Thr Leu Ala Pro Gly Leu Ser Thr His Glu Asp Cys Leu Ala Gly 
    50                  55                  60                  


Ala Trp Val Ala Thr Val Ile Gly Leu Pro Leu Leu Ala Phe Asp Phe 
65                  70                  75                  80  


His Trp Val Asn Gly Asp Arg Ser Ser Ala Asn Leu Leu Leu Gly Gly 
                85                  90                  95      


Gly Met Val Leu Ala Val Ala Gly Gly His Leu Gly Pro Glu Gly Arg 
            100                 105                 110         


Ser Val Ala Gly Gln Ala Met Leu Leu Val Val Ala Val Thr Ile Leu 
        115                 120                 125             


Ile Val Ala Val Phe Thr Ala Asn Thr Tyr Gly Met Trp Gly Gly Ala 
    130                 135                 140                 


Met Leu Gly Val Ala Gly Leu Leu Ser Arg Leu Glu Glu Asp Arg Leu 
145                 150                 155                 160 


Leu Leu Leu Pro Lys Glu Asp Val Cys Arg Trp Ala Leu Ala Val Gly 
                165                 170                 175     


Ser Trp Ala Tyr Cys Arg Ala Leu His Thr Gln Arg Leu Gln Trp Glu 
            180                 185                 190         


<210>  3830
<211>  246
<212>  PRT
<213>  Homo Sapiens

<400>  3830

Met Ala Pro Lys Pro Gly Ala Glu Trp Ser Thr Ala Leu Ser His Leu 
1               5                   10                  15      


Val Leu Gly Val Val Ser Leu His Ala Ala Val Ser Thr Ala Glu Cys 
            20                  25                  30          


Thr Asn Gly His Leu Met Cys Ala Gly Cys Phe Ile His Leu Leu Ala 
        35                  40                  45              


Asp Ala Arg Leu Lys Glu Glu Gln Ala Thr Cys Pro Asn Cys Arg Cys 
    50                  55                  60                  


Glu Ile Ser Lys Ser Leu Cys Cys Arg Asn Leu Ala Val Glu Lys Ala 
65                  70                  75                  80  


Val Ser Glu Leu Pro Ser Glu Cys Gly Phe Cys Leu Arg Gln Phe Pro 
                85                  90                  95      


Arg Ser Leu Leu Glu Arg His Gln Lys Glu Glu Cys Gln Asp Arg Val 
            100                 105                 110         


Thr Gln Cys Lys Tyr Lys Arg Ile Gly Cys Pro Trp His Gly Pro Phe 
        115                 120                 125             


His Glu Leu Thr Val His Glu Ala Ala Cys Ala His Pro Thr Lys Thr 
    130                 135                 140                 


Gly Ser Glu Leu Met Glu Ile Leu Asp Gly Met Asp Gln Ser His Arg 
145                 150                 155                 160 


Lys Glu Met Gln Leu Tyr Asn Ser Ile Phe Ser Leu Leu Ser Phe Glu 
                165                 170                 175     


Lys Ile Gly Tyr Thr Glu Val Gln Phe Arg Pro Tyr Arg Thr Asp Asp 
            180                 185                 190         


Phe Ile Thr Arg Leu Tyr Tyr Glu Thr Pro Arg Phe Thr Val Leu Asn 
        195                 200                 205             


Gln Thr Trp Val Leu Lys Ala Arg Val Asn Asp Ser Glu Arg Asn Pro 
    210                 215                 220                 


Asn Leu Ser Cys Lys Arg Thr Leu Ser Phe Gln Leu Leu Leu Lys Ser 
225                 230                 235                 240 


Lys Val Thr Ala Pro Leu 
                245     


<210>  3831
<211>  404
<212>  PRT
<213>  Homo Sapiens

<400>  3831

Met Ser Gly Ala Glu Glu Ala Gly Gly Gly Gly Pro Ala Ala Gly Pro 
1               5                   10                  15      


Ala Gly Ser Val Pro Ala Gly Val Gly Val Gly Val Gly Ala Gly Pro 
            20                  25                  30          


Gly Ala Ala Ala Gly Gln Ala Ala Ala Ala Ala Leu Gly Glu Ala Ala 
        35                  40                  45              


Gly Pro Gly Leu Pro Asp Glu Ala Gly Leu Ala Gly Ala Arg Gln Leu 
    50                  55                  60                  


Gln Leu Gln Glu Ala Ala Gly Asp Pro Asp Ala Pro Pro Lys Lys Arg 
65                  70                  75                  80  


Leu Arg Ala Ala Glu Ala Ala Glu Ala Ala Ala Ala Ala Ala Ala Ala 
                85                  90                  95      


Gly Ser Gly Lys Leu Glu Glu Arg Leu Tyr Ser Val Leu Cys Cys Thr 
            100                 105                 110         


Val Cys Leu Asp Leu Pro Lys Ala Ser Val Tyr Gln Cys Thr Asn Gly 
        115                 120                 125             


His Leu Met Cys Ala Gly Cys Phe Ile His Leu Leu Ala Asp Ala Arg 
    130                 135                 140                 


Leu Lys Glu Glu Gln Ala Thr Cys Pro Asn Cys Arg Cys Glu Ile Ser 
145                 150                 155                 160 


Lys Ser Leu Cys Cys Arg Asn Leu Ala Val Glu Lys Ala Val Ser Glu 
                165                 170                 175     


Leu Pro Ser Glu Cys Gly Phe Cys Leu Arg Gln Phe Pro Arg Ser Leu 
            180                 185                 190         


Leu Glu Arg His Gln Lys Glu Glu Cys Gln Asp Arg Val Thr Gln Cys 
        195                 200                 205             


Lys Tyr Lys Arg Ile Gly Cys Pro Trp His Gly Pro Phe His Glu Leu 
    210                 215                 220                 


Thr Val His Glu Ala Ala Cys Ala His Pro Thr Lys Thr Gly Ser Glu 
225                 230                 235                 240 


Leu Met Glu Ile Leu Asp Gly Met Asp Gln Ser His Arg Lys Glu Met 
                245                 250                 255     


Gln Leu Tyr Asn Ser Ile Phe Ser Leu Leu Ser Phe Glu Lys Ile Gly 
            260                 265                 270         


Tyr Thr Glu Val Gln Phe Arg Pro Tyr Arg Thr Asp Asp Phe Ile Thr 
        275                 280                 285             


Arg Leu Tyr Tyr Glu Thr Pro Arg Phe Thr Val Leu Asn Gln Thr Trp 
    290                 295                 300                 


Val Leu Lys Ala Arg Val Asn Asp Ser Glu Arg Asn Pro Asn Leu Ser 
305                 310                 315                 320 


Cys Lys Arg Thr Leu Ser Phe Gln Leu Leu Leu Lys Ser Lys Val Thr 
                325                 330                 335     


Ala Pro Leu Glu Cys Ser Phe Leu Leu Leu Lys Gly Pro Tyr Asp Asp 
            340                 345                 350         


Val Arg Ile Ser Pro Val Ile Tyr His Phe Val Phe Thr Asn Glu Ser 
        355                 360                 365             


Asn Glu Thr Asp Tyr Val Pro Leu Pro Ile Ile Asp Ser Val Glu Cys 
    370                 375                 380                 


Asn Lys Leu Leu Ala Ala Lys Asn Ile Asn Leu Arg Leu Phe Leu Phe 
385                 390                 395                 400 


Gln Ile Gln Lys 
                


<210>  3832
<211>  479
<212>  PRT
<213>  Homo Sapiens

<400>  3832

Met Trp Glu Leu Val Ala Leu Leu Leu Leu Thr Leu Ala Tyr Leu Phe 
1               5                   10                  15      


Trp Pro Lys Arg Arg Cys Pro Gly Ala Lys Tyr Pro Lys Ser Leu Leu 
            20                  25                  30          


Ser Leu Pro Leu Val Gly Ser Leu Pro Phe Leu Pro Arg His Gly His 
        35                  40                  45              


Met His Asn Asn Phe Phe Lys Leu Gln Lys Lys Tyr Gly Pro Ile Tyr 
    50                  55                  60                  


Ser Val Arg Met Gly Thr Lys Thr Thr Val Ile Val Gly His His Gln 
65                  70                  75                  80  


Leu Ala Lys Glu Val Leu Ile Lys Lys Gly Lys Asp Phe Ser Gly Arg 
                85                  90                  95      


Pro Gln Met Ala Thr Leu Asp Ile Ala Ser Asn Asn Arg Lys Gly Ile 
            100                 105                 110         


Ala Phe Ala Asp Ser Gly Ala His Trp Gln Leu His Arg Arg Leu Ala 
        115                 120                 125             


Met Ala Thr Phe Ala Leu Phe Lys Asp Gly Asp Gln Lys Leu Glu Lys 
    130                 135                 140                 


Ile Ile Cys Gln Glu Ile Ser Thr Leu Cys Asp Met Leu Ala Thr His 
145                 150                 155                 160 


Asn Gly Gln Ser Ile Asp Ile Ser Phe Pro Val Phe Val Ala Val Thr 
                165                 170                 175     


Asn Val Ile Ser Leu Ile Cys Phe Asn Thr Ser Tyr Lys Asn Gly Asp 
            180                 185                 190         


Pro Glu Leu Asn Val Ile Gln Asn Tyr Asn Glu Gly Ile Ile Asp Asn 
        195                 200                 205             


Leu Ser Lys Asp Ser Leu Val Asp Leu Val Pro Trp Leu Lys Glu Lys 
    210                 215                 220                 


Phe Arg Ser Asp Ser Ile Thr Asn Met Leu Asp Thr Leu Met Gln Ala 
225                 230                 235                 240 


Lys Met Asn Ser Asp Asn Gly Asn Ala Gly Pro Asp Gln Asp Ser Glu 
                245                 250                 255     


Leu Leu Ser Asp Asn His Ile Leu Thr Thr Ile Gly Asp Ile Phe Gly 
            260                 265                 270         


Ala Gly Val Glu Thr Thr Thr Ser Val Val Lys Trp Thr Leu Ala Phe 
        275                 280                 285             


Leu Leu His Asn Pro Gln Val Lys Lys Lys Leu Tyr Glu Glu Ile Asp 
    290                 295                 300                 


Gln Asn Val Gly Phe Ser Arg Thr Pro Thr Ile Ser Asp Arg Asn Arg 
305                 310                 315                 320 


Leu Leu Leu Leu Glu Ala Thr Ile Arg Glu Val Leu Arg Leu Arg Pro 
                325                 330                 335     


Val Ala Pro Met Leu Ile Pro His Lys Ala Asn Val Asp Ser Ser Ile 
            340                 345                 350         


Gly Glu Phe Ala Val Asp Lys Gly Thr Glu Val Ile Ile Asn Leu Trp 
        355                 360                 365             


Ala Leu His His Asn Glu Lys Glu Trp His Gln Pro Asp Gln Phe Met 
    370                 375                 380                 


Pro Glu Arg Phe Leu Asn Pro Ala Gly Thr Gln Leu Ile Ser Pro Ser 
385                 390                 395                 400 


Val Ser Tyr Leu Pro Phe Gly Ala Gly Pro Arg Ser Cys Ile Gly Glu 
                405                 410                 415     


Ile Leu Ala Arg Gln Glu Leu Phe Leu Ile Met Ala Trp Leu Leu Gln 
            420                 425                 430         


Arg Phe Asp Leu Glu Val Pro Asp Asp Gly Gln Leu Pro Ser Leu Glu 
        435                 440                 445             


Gly Ile Pro Lys Val Val Phe Leu Ile Asp Ser Phe Lys Val Lys Ile 
    450                 455                 460                 


Lys Val Arg Gln Ala Trp Arg Glu Ala Gln Ala Glu Gly Ser Thr 
465                 470                 475                 


<210>  3833
<211>  508
<212>  PRT
<213>  Homo Sapiens

<400>  3833

Met Trp Glu Leu Val Ala Leu Leu Leu Leu Thr Leu Ala Tyr Leu Phe 
1               5                   10                  15      


Trp Pro Lys Arg Arg Cys Pro Gly Ala Lys Tyr Pro Lys Ser Leu Leu 
            20                  25                  30          


Ser Leu Pro Leu Val Gly Ser Leu Pro Phe Leu Pro Arg His Gly His 
        35                  40                  45              


Met His Asn Asn Phe Phe Lys Leu Gln Lys Lys Tyr Gly Pro Ile Tyr 
    50                  55                  60                  


Ser Val Arg Met Gly Thr Lys Thr Thr Val Ile Val Gly His His Gln 
65                  70                  75                  80  


Leu Ala Lys Glu Val Leu Ile Lys Lys Gly Lys Asp Phe Ser Gly Arg 
                85                  90                  95      


Pro Gln Met Ala Thr Leu Asp Ile Ala Ser Asn Asn Arg Lys Gly Ile 
            100                 105                 110         


Ala Phe Ala Asp Ser Gly Ala His Trp Gln Leu His Arg Arg Leu Ala 
        115                 120                 125             


Met Ala Thr Phe Ala Leu Phe Lys Asp Gly Asp Gln Lys Leu Glu Lys 
    130                 135                 140                 


Ile Ile Cys Gln Glu Ile Ser Thr Leu Cys Asp Met Leu Ala Thr His 
145                 150                 155                 160 


Asn Gly Gln Ser Ile Asp Ile Ser Phe Pro Val Phe Val Ala Val Thr 
                165                 170                 175     


Asn Val Ile Ser Leu Ile Cys Phe Asn Thr Ser Tyr Lys Asn Gly Asp 
            180                 185                 190         


Pro Glu Leu Asn Val Ile Gln Asn Tyr Asn Glu Gly Ile Ile Asp Asn 
        195                 200                 205             


Leu Ser Lys Asp Ser Leu Val Asp Leu Val Pro Trp Leu Lys Ile Phe 
    210                 215                 220                 


Pro Asn Lys Thr Leu Glu Lys Leu Lys Ser His Val Lys Ile Arg Asn 
225                 230                 235                 240 


Asp Leu Leu Asn Lys Ile Leu Glu Asn Tyr Lys Glu Lys Phe Arg Ser 
                245                 250                 255     


Asp Ser Ile Thr Asn Met Leu Asp Thr Leu Met Gln Ala Lys Met Asn 
            260                 265                 270         


Ser Asp Asn Gly Asn Ala Gly Pro Asp Gln Asp Ser Glu Leu Leu Ser 
        275                 280                 285             


Asp Asn His Ile Leu Thr Thr Ile Gly Asp Ile Phe Gly Ala Gly Val 
    290                 295                 300                 


Glu Thr Thr Thr Ser Val Val Lys Trp Thr Leu Ala Phe Leu Leu His 
305                 310                 315                 320 


Asn Pro Gln Val Lys Lys Lys Leu Tyr Glu Glu Ile Asp Gln Asn Val 
                325                 330                 335     


Gly Phe Ser Arg Thr Pro Thr Ile Ser Asp Arg Asn Arg Leu Leu Leu 
            340                 345                 350         


Leu Glu Ala Thr Ile Arg Glu Val Leu Arg Leu Arg Pro Val Ala Pro 
        355                 360                 365             


Met Leu Ile Pro His Lys Ala Asn Val Asp Ser Ser Ile Gly Glu Phe 
    370                 375                 380                 


Ala Val Asp Lys Gly Thr Glu Val Ile Ile Asn Leu Trp Ala Leu His 
385                 390                 395                 400 


His Asn Glu Lys Glu Trp His Gln Pro Asp Gln Phe Met Pro Glu Arg 
                405                 410                 415     


Phe Leu Asn Pro Ala Gly Thr Gln Leu Ile Ser Pro Ser Val Ser Tyr 
            420                 425                 430         


Leu Pro Phe Gly Ala Gly Pro Arg Ser Cys Ile Gly Glu Ile Leu Ala 
        435                 440                 445             


Arg Gln Glu Leu Phe Leu Ile Met Ala Trp Leu Leu Gln Arg Phe Asp 
    450                 455                 460                 


Leu Glu Val Pro Asp Asp Gly Gln Leu Pro Ser Leu Glu Gly Ile Pro 
465                 470                 475                 480 


Lys Val Val Phe Leu Ile Asp Ser Phe Lys Val Lys Ile Lys Val Arg 
                485                 490                 495     


Gln Ala Trp Arg Glu Ala Gln Ala Glu Gly Ser Thr 
            500                 505             


<210>  3834
<211>  509
<212>  PRT
<213>  Homo Sapiens

<400>  3834

Met Trp Glu Leu Val Ala Leu Leu Leu Leu Thr Leu Ala Tyr Leu Phe 
1               5                   10                  15      


Trp Pro Lys Arg Arg Cys Pro Gly Ala Lys Tyr Pro Lys Ser Leu Leu 
            20                  25                  30          


Ser Leu Pro Leu Val Gly Ser Leu Pro Phe Leu Pro Arg His Gly His 
        35                  40                  45              


Met His Asn Asn Phe Phe Lys Leu Gln Lys Lys Tyr Gly Pro Ile Tyr 
    50                  55                  60                  


Ser Val Arg Met Gly Thr Lys Thr Thr Val Ile Val Gly His His Gln 
65                  70                  75                  80  


Leu Ala Lys Glu Val Leu Ile Lys Lys Gly Lys Asp Phe Ser Gly Arg 
                85                  90                  95      


Pro Gln Met Ala Thr Leu Asp Ile Ala Ser Asn Asn Arg Lys Gly Ile 
            100                 105                 110         


Ala Phe Ala Asp Ser Gly Ala His Trp Gln Leu His Arg Arg Leu Ala 
        115                 120                 125             


Met Ala Thr Phe Ala Leu Phe Lys Asp Gly Asp Gln Lys Leu Glu Lys 
    130                 135                 140                 


Ile Ile Cys Gln Glu Ile Ser Thr Leu Cys Asp Met Leu Ala Thr His 
145                 150                 155                 160 


Asn Gly Gln Ser Ile Asp Ile Ser Phe Pro Val Phe Val Ala Val Thr 
                165                 170                 175     


Asn Val Ile Ser Leu Ile Cys Phe Asn Thr Ser Tyr Lys Asn Gly Asp 
            180                 185                 190         


Pro Glu Leu Asn Val Ile Gln Asn Tyr Asn Glu Gly Ile Ile Asp Asn 
        195                 200                 205             


Leu Ser Lys Asp Ser Leu Val Asp Leu Val Pro Trp Leu Lys Ile Phe 
    210                 215                 220                 


Pro Asn Lys Thr Leu Glu Lys Leu Lys Ser His Val Lys Ile Arg Asn 
225                 230                 235                 240 


Asp Leu Leu Asn Lys Ile Leu Glu Asn Tyr Lys Glu Lys Phe Arg Ser 
                245                 250                 255     


Asp Ser Ile Thr Asn Met Leu Asp Thr Leu Met Gln Ala Lys Met Asn 
            260                 265                 270         


Ser Asp Asn Gly Asn Ala Gly Pro Asp Gln Asp Ser Glu Leu Leu Ser 
        275                 280                 285             


Asp Asn His Ile Leu Thr Thr Ile Gly Asp Ile Phe Gly Ala Gly Val 
    290                 295                 300                 


Glu Thr Thr Thr Ser Val Val Lys Trp Thr Leu Ala Phe Leu Leu His 
305                 310                 315                 320 


Asn Pro Gln Val Lys Lys Lys Leu Tyr Glu Glu Ile Asp Gln Asn Val 
                325                 330                 335     


Gly Phe Ser Arg Thr Pro Thr Ile Ser Asp Arg Asn Arg Leu Leu Leu 
            340                 345                 350         


Leu Glu Ala Thr Ile Arg Glu Val Leu Arg Leu Arg Pro Val Ala Pro 
        355                 360                 365             


Met Leu Ile Pro His Lys Ala Asn Val Asp Ser Ser Ser Ile Gly Glu 
    370                 375                 380                 


Phe Ala Val Asp Lys Gly Thr Glu Val Ile Ile Asn Leu Trp Ala Leu 
385                 390                 395                 400 


His His Asn Glu Lys Glu Trp His Gln Pro Asp Gln Phe Met Pro Glu 
                405                 410                 415     


Arg Phe Leu Asn Pro Ala Gly Thr Gln Leu Ile Ser Pro Ser Val Ser 
            420                 425                 430         


Tyr Leu Pro Phe Gly Ala Gly Pro Arg Ser Cys Ile Gly Glu Ile Leu 
        435                 440                 445             


Ala Arg Gln Glu Leu Phe Leu Ile Met Ala Trp Leu Leu Gln Arg Phe 
    450                 455                 460                 


Asp Leu Glu Val Pro Asp Asp Gly Gln Leu Pro Ser Leu Glu Gly Ile 
465                 470                 475                 480 


Pro Lys Val Val Phe Leu Ile Asp Ser Phe Lys Val Lys Ile Lys Val 
                485                 490                 495     


Arg Gln Ala Trp Arg Glu Ala Gln Ala Glu Gly Ser Thr 
            500                 505                 


<210>  3835
<211>  407
<212>  PRT
<213>  Homo Sapiens

<400>  3835

Met Trp Glu Leu Val Ala Leu Leu Leu Leu Thr Leu Ala Tyr Leu Phe 
1               5                   10                  15      


Trp Pro Lys Arg Arg Cys Pro Gly Ala Lys Tyr Pro Lys Ser Leu Leu 
            20                  25                  30          


Ser Leu Pro Leu Val Gly Ser Leu Pro Phe Leu Pro Arg His Gly His 
        35                  40                  45              


Met His Asn Asn Phe Phe Lys Leu Gln Lys Lys Tyr Gly Pro Ile Tyr 
    50                  55                  60                  


Ser Val Arg Met Gly Thr Lys Thr Thr Val Ile Val Gly His His Gln 
65                  70                  75                  80  


Leu Ala Lys Glu Val Leu Ile Lys Lys Gly Lys Asp Phe Ser Gly Arg 
                85                  90                  95      


Pro Gln Met Ala Thr Leu Asp Ile Ala Ser Asn Asn Arg Lys Gly Ile 
            100                 105                 110         


Ala Phe Ala Asp Ser Gly Ala His Trp Gln Leu His Arg Arg Leu Ala 
        115                 120                 125             


Met Ala Thr Phe Ala Leu Phe Lys Asp Gly Asp Gln Lys Leu Glu Lys 
    130                 135                 140                 


Ile Ile Cys Gln Glu Ile Ser Thr Leu Cys Asp Met Leu Ala Thr His 
145                 150                 155                 160 


Asn Gly Gln Ser Ile Asp Ile Ser Phe Pro Val Phe Val Ala Val Thr 
                165                 170                 175     


Asn Val Ile Ser Leu Ile Cys Phe Asn Thr Ser Tyr Lys Asn Gly Asp 
            180                 185                 190         


Pro Glu Leu Asn Val Ile Gln Asn Tyr Asn Glu Gly Ile Ile Asp Asn 
        195                 200                 205             


Leu Ser Lys Asp Ser Leu Val Asp Leu Val Pro Trp Leu Lys Val Lys 
    210                 215                 220                 


Lys Lys Leu Tyr Glu Glu Ile Asp Gln Asn Val Gly Phe Ser Arg Thr 
225                 230                 235                 240 


Pro Thr Ile Ser Asp Arg Asn Arg Leu Leu Leu Leu Glu Ala Thr Ile 
                245                 250                 255     


Arg Glu Val Leu Arg Leu Arg Pro Val Ala Pro Met Leu Ile Pro His 
            260                 265                 270         


Lys Ala Asn Val Asp Ser Ser Ile Gly Glu Phe Ala Val Asp Lys Gly 
        275                 280                 285             


Thr Glu Val Ile Ile Asn Leu Trp Ala Leu His His Asn Glu Lys Glu 
    290                 295                 300                 


Trp His Gln Pro Asp Gln Phe Met Pro Glu Arg Phe Leu Asn Pro Ala 
305                 310                 315                 320 


Gly Thr Gln Leu Ile Ser Pro Ser Val Ser Tyr Leu Pro Phe Gly Ala 
                325                 330                 335     


Gly Pro Arg Ser Cys Ile Gly Glu Ile Leu Ala Arg Gln Glu Leu Phe 
            340                 345                 350         


Leu Ile Met Ala Trp Leu Leu Gln Arg Phe Asp Leu Glu Val Pro Asp 
        355                 360                 365             


Asp Gly Gln Leu Pro Ser Leu Glu Gly Ile Pro Lys Val Val Phe Leu 
    370                 375                 380                 


Ile Asp Ser Phe Lys Val Lys Ile Lys Val Arg Gln Ala Trp Arg Glu 
385                 390                 395                 400 


Ala Gln Ala Glu Gly Ser Thr 
                405         


<210>  3836
<211>  356
<212>  PRT
<213>  Homo Sapiens

<400>  3836

Met Trp Glu Leu Val Ala Leu Leu Leu Leu Thr Leu Ala Tyr Leu Phe 
1               5                   10                  15      


Trp Pro Lys Arg Arg Cys Pro Gly Ala Lys Tyr Pro Lys Ser Leu Leu 
            20                  25                  30          


Ser Leu Pro Leu Val Gly Ser Leu Pro Phe Leu Pro Arg His Gly His 
        35                  40                  45              


Met His Asn Asn Phe Phe Lys Leu Gln Lys Lys Tyr Gly Pro Ile Tyr 
    50                  55                  60                  


Ser Val Arg Met Gly Thr Lys Thr Thr Val Ile Val Gly His His Gln 
65                  70                  75                  80  


Leu Ala Lys Glu Val Leu Ile Lys Lys Gly Lys Asp Phe Ser Gly Arg 
                85                  90                  95      


Pro Gln Met Glu Lys Phe Arg Ser Asp Ser Ile Thr Asn Met Leu Asp 
            100                 105                 110         


Thr Leu Met Gln Ala Lys Met Asn Ser Asp Asn Gly Asn Ala Gly Pro 
        115                 120                 125             


Asp Gln Asp Ser Glu Leu Leu Ser Asp Asn His Ile Leu Thr Thr Ile 
    130                 135                 140                 


Gly Asp Ile Phe Gly Ala Gly Val Glu Thr Thr Thr Ser Val Val Lys 
145                 150                 155                 160 


Trp Thr Leu Ala Phe Leu Leu His Asn Pro Gln Val Lys Lys Lys Leu 
                165                 170                 175     


Tyr Glu Glu Ile Asp Gln Asn Val Gly Phe Ser Arg Thr Pro Thr Ile 
            180                 185                 190         


Ser Asp Arg Asn Arg Leu Leu Leu Leu Glu Ala Thr Ile Arg Glu Val 
        195                 200                 205             


Leu Arg Leu Arg Pro Val Ala Pro Met Leu Ile Pro His Lys Ala Asn 
    210                 215                 220                 


Val Asp Ser Ser Ile Gly Glu Phe Ala Val Asp Lys Gly Thr Glu Val 
225                 230                 235                 240 


Ile Ile Asn Leu Trp Ala Leu His His Asn Glu Lys Glu Trp His Gln 
                245                 250                 255     


Pro Asp Gln Phe Met Pro Glu Arg Phe Leu Asn Pro Ala Gly Thr Gln 
            260                 265                 270         


Leu Ile Ser Pro Ser Val Ser Tyr Leu Pro Phe Gly Ala Gly Pro Arg 
        275                 280                 285             


Ser Cys Ile Gly Glu Ile Leu Ala Arg Gln Glu Leu Phe Leu Ile Met 
    290                 295                 300                 


Ala Trp Leu Leu Gln Arg Phe Asp Leu Glu Val Pro Asp Asp Gly Gln 
305                 310                 315                 320 


Leu Pro Ser Leu Glu Gly Ile Pro Lys Val Val Phe Leu Ile Asp Ser 
                325                 330                 335     


Phe Lys Val Lys Ile Lys Val Arg Gln Ala Trp Arg Glu Ala Gln Ala 
            340                 345                 350         


Glu Gly Ser Thr 
        355     


<210>  3837
<211>  192
<212>  PRT
<213>  Homo Sapiens

<400>  3837

Met Ile Phe Ser Leu Ala Ser Cys Ile Ile Thr Ala Lys Leu Cys Thr 
1               5                   10                  15      


Trp Ala Ile Cys Phe Leu Thr Thr Ser Glu Glu Val Gln Lys Lys Leu 
            20                  25                  30          


Tyr Glu Glu Ile Asn Gln Val Phe Gly Asn Gly Pro Val Thr Pro Glu 
        35                  40                  45              


Lys Ile Glu Gln Leu Arg Tyr Cys Gln His Val Leu Cys Glu Thr Val 
    50                  55                  60                  


Arg Thr Ala Lys Leu Thr Pro Val Ser Ala Gln Leu Gln Asp Ile Glu 
65                  70                  75                  80  


Gly Lys Ile Asp Arg Phe Ile Ile Pro Arg Glu Thr Leu Val Leu Tyr 
                85                  90                  95      


Ala Leu Gly Val Val Leu Gln Asp Pro Asn Thr Trp Pro Ser Pro His 
            100                 105                 110         


Lys Phe Asp Pro Asp Arg Phe Asp Asp Glu Leu Val Met Lys Thr Phe 
        115                 120                 125             


Ser Ser Leu Gly Phe Ser Gly Thr Gln Glu Cys Pro Glu Leu Arg Phe 
    130                 135                 140                 


Ala Tyr Met Val Thr Thr Val Leu Leu Ser Val Leu Val Lys Arg Leu 
145                 150                 155                 160 


His Leu Leu Ser Val Glu Gly Gln Val Ile Glu Thr Lys Tyr Glu Leu 
                165                 170                 175     


Val Thr Ser Ser Arg Glu Glu Ala Trp Ile Thr Val Ser Lys Arg Tyr 
            180                 185                 190         


<210>  3838
<211>  258
<212>  PRT
<213>  Homo Sapiens

<400>  3838

Met Leu Asp Phe Ala Ile Phe Ala Val Thr Phe Leu Leu Ala Leu Val 
1               5                   10                  15      


Gly Ala Val Leu Tyr Leu Tyr Pro Ala Ser Arg Gln Ala Ala Gly Ile 
            20                  25                  30          


Pro Gly Ile Thr Pro Thr Glu Glu Lys Asp Gly Asn Leu Pro Asp Ile 
        35                  40                  45              


Val Asn Ser Gly Ser Leu His Glu Phe Leu Val Asn Leu His Glu Arg 
    50                  55                  60                  


Tyr Gly Pro Val Val Ser Phe Trp Phe Gly Arg Arg Leu Val Val Ser 
65                  70                  75                  80  


Leu Gly Thr Val Asp Val Leu Lys Gln His Ile Asn Pro Asn Lys Thr 
                85                  90                  95      


Ser Asp Pro Phe Glu Thr Met Leu Lys Ser Leu Leu Arg Tyr Gln Ser 
            100                 105                 110         


Gly Gly Gly Ser Val Ser Glu Asn His Met Arg Lys Lys Leu Tyr Glu 
        115                 120                 125             


Asn Gly Val Thr Asp Ser Leu Lys Ser Asn Phe Ala Leu Leu Leu Lys 
    130                 135                 140                 


Leu Ser Glu Glu Leu Leu Asp Lys Trp Leu Ser Tyr Pro Glu Thr Gln 
145                 150                 155                 160 


His Val Pro Leu Ser Gln His Met Leu Gly Phe Ala Met Lys Ser Val 
                165                 170                 175     


Thr Gln Met Val Met Gly Ser Thr Phe Glu Asp Asp Gln Glu Val Ile 
            180                 185                 190         


Arg Phe Gln Lys Asn His Gly Thr Ile Leu Glu Asp Ser Met Ile Phe 
        195                 200                 205             


Ser Leu Ala Ser Cys Ile Ile Thr Ala Lys Leu Cys Thr Trp Ala Ile 
    210                 215                 220                 


Cys Phe Leu Thr Thr Ser Glu Glu Val Gln Lys Lys Leu Tyr Glu Glu 
225                 230                 235                 240 


Ile Asn Gln Val Phe Gly Asn Gly Pro Val Thr Pro Glu Lys Ile Glu 
                245                 250                 255     


Gln Leu 
        


<210>  3839
<211>  470
<212>  PRT
<213>  Homo Sapiens

<400>  3839

Met Leu Asp Phe Ala Ile Phe Ala Val Thr Phe Leu Leu Ala Leu Val 
1               5                   10                  15      


Gly Ala Val Leu Tyr Leu Tyr Pro Ala Ser Arg Gln Ala Ala Gly Ile 
            20                  25                  30          


Pro Gly Ile Thr Pro Thr Glu Glu Lys Asp Gly Asn Leu Pro Asp Ile 
        35                  40                  45              


Val Asn Ser Gly Ser Leu His Glu Phe Leu Val Asn Leu His Glu Arg 
    50                  55                  60                  


Tyr Gly Pro Val Val Ser Phe Trp Phe Gly Arg Arg Leu Val Val Ser 
65                  70                  75                  80  


Leu Gly Thr Val Asp Val Leu Lys Gln His Ile Asn Pro Asn Lys Thr 
                85                  90                  95      


Ser Asp Pro Phe Glu Thr Met Leu Lys Ser Leu Leu Arg Tyr Gln Ser 
            100                 105                 110         


Gly Gly Gly Ser Val Ser Glu Asn His Met Arg Lys Lys Leu Tyr Glu 
        115                 120                 125             


Asn Gly Val Thr Asp Ser Leu Lys Ser Asn Phe Ala Leu Leu Leu Lys 
    130                 135                 140                 


Leu Ser Glu Glu Leu Leu Asp Lys Trp Leu Ser Tyr Pro Glu Thr Gln 
145                 150                 155                 160 


His Val Pro Leu Ser Gln His Met Leu Gly Phe Ala Met Lys Ser Val 
                165                 170                 175     


Thr Gln Met Val Met Gly Ser Thr Phe Glu Asp Asp Gln Glu Val Ile 
            180                 185                 190         


Arg Phe Gln Lys Asn His Gly Thr Leu Cys Ile Phe Thr Tyr Phe Gln 
        195                 200                 205             


Val Trp Ser Glu Ile Gly Lys Gly Phe Leu Asp Gly Ser Leu Asp Lys 
    210                 215                 220                 


Asn Met Thr Arg Lys Lys Gln Tyr Glu Asp Ala Leu Met Gln Leu Glu 
225                 230                 235                 240 


Ser Val Leu Arg Asn Ile Ile Lys Glu Arg Lys Gly Arg Asn Phe Ser 
                245                 250                 255     


Gln His Ile Phe Ile Asp Ser Leu Val Gln Gly Asn Leu Asn Asp Gln 
            260                 265                 270         


Gln Ile Leu Glu Asp Ser Met Ile Phe Ser Leu Ala Ser Cys Ile Ile 
        275                 280                 285             


Thr Ala Lys Leu Cys Thr Trp Ala Ile Cys Phe Leu Thr Thr Ser Glu 
    290                 295                 300                 


Glu Val Gln Lys Lys Leu Tyr Glu Glu Ile Asn Gln Val Phe Gly Asn 
305                 310                 315                 320 


Gly Pro Val Thr Pro Glu Lys Ile Glu Gln Leu Arg Tyr Cys Gln His 
                325                 330                 335     


Val Leu Cys Glu Thr Val Arg Thr Ala Lys Leu Thr Pro Val Ser Ala 
            340                 345                 350         


Gln Leu Gln Asp Ile Glu Gly Lys Ile Asp Arg Phe Ile Ile Pro Arg 
        355                 360                 365             


Glu Thr Leu Val Leu Tyr Ala Leu Gly Val Val Leu Gln Asp Pro Asn 
    370                 375                 380                 


Thr Trp Pro Ser Pro His Lys Phe Asp Pro Asp Arg Phe Asp Asp Glu 
385                 390                 395                 400 


Leu Val Met Lys Thr Phe Ser Ser Leu Gly Phe Ser Gly Thr Gln Glu 
                405                 410                 415     


Cys Pro Glu Leu Arg Phe Ala Tyr Met Val Thr Thr Val Leu Leu Ser 
            420                 425                 430         


Val Leu Val Lys Arg Leu His Leu Leu Ser Val Glu Gly Gln Val Ile 
        435                 440                 445             


Glu Thr Lys Tyr Glu Leu Val Thr Ser Ser Arg Glu Glu Ala Trp Ile 
    450                 455                 460                 


Thr Val Ser Lys Arg Tyr 
465                 470 


<210>  3840
<211>  208
<212>  PRT
<213>  Homo Sapiens

<400>  3840

Met Leu Asp Phe Ala Ile Phe Ala Val Thr Phe Leu Leu Ala Leu Val 
1               5                   10                  15      


Gly Ala Val Leu Tyr Leu Tyr Pro Ala Ser Arg Gln Ala Ala Gly Ile 
            20                  25                  30          


Pro Gly Ile Thr Pro Thr Glu Glu Lys Asp Gly Asn Leu Pro Asp Ile 
        35                  40                  45              


Val Asn Ser Gly Ser Leu His Glu Phe Leu Val Asn Leu His Glu Arg 
    50                  55                  60                  


Tyr Gly Pro Val Val Ser Phe Trp Phe Gly Arg Arg Leu Val Val Ser 
65                  70                  75                  80  


Leu Gly Thr Val Asp Val Leu Lys Gln His Ile Asn Pro Asn Lys Thr 
                85                  90                  95      


Ser Asp Pro Phe Glu Thr Met Leu Lys Ser Leu Leu Arg Tyr Gln Ser 
            100                 105                 110         


Gly Gly Gly Ser Val Ser Glu Asn His Met Arg Lys Lys Leu Tyr Glu 
        115                 120                 125             


Asn Gly Val Thr Asp Ser Leu Lys Ser Asn Phe Ala Leu Leu Leu Lys 
    130                 135                 140                 


Leu Ser Glu Glu Leu Leu Asp Lys Trp Leu Ser Tyr Pro Glu Thr Gln 
145                 150                 155                 160 


His Val Pro Leu Ser Gln His Met Leu Gly Phe Ala Met Lys Ser Val 
                165                 170                 175     


Thr Gln Met Val Met Gly Ser Thr Phe Glu Asp Asp Gln Glu Val Ile 
            180                 185                 190         


Arg Phe Gln Lys Asn His Gly Thr Pro Ser Cys Asn Trp Ser Leu Phe 
        195                 200                 205             


<210>  3841
<211>  462
<212>  PRT
<213>  Homo Sapiens

<400>  3841

Met Leu Asp Phe Ala Ile Phe Ala Val Thr Phe Leu Leu Ala Leu Val 
1               5                   10                  15      


Gly Ala Val Leu Tyr Leu Tyr Pro Ala Ser Arg Gln Ala Ala Gly Ile 
            20                  25                  30          


Pro Gly Ile Thr Pro Thr Glu Glu Lys Asp Gly Asn Leu Pro Asp Ile 
        35                  40                  45              


Val Asn Ser Gly Ser Leu His Glu Phe Leu Val Asn Leu His Glu Arg 
    50                  55                  60                  


Tyr Gly Pro Val Val Ser Phe Trp Phe Gly Arg Arg Leu Val Val Ser 
65                  70                  75                  80  


Leu Gly Thr Val Asp Val Leu Lys Gln His Ile Asn Pro Asn Lys Thr 
                85                  90                  95      


Ser Asp Pro Phe Glu Thr Met Leu Lys Ser Leu Leu Arg Tyr Gln Ser 
            100                 105                 110         


Gly Gly Gly Ser Val Ser Glu Asn His Met Arg Lys Lys Leu Tyr Glu 
        115                 120                 125             


Asn Gly Val Thr Asp Ser Leu Lys Ser Asn Phe Ala Leu Leu Leu Lys 
    130                 135                 140                 


Leu Ser Glu Glu Leu Leu Asp Lys Trp Leu Ser Tyr Pro Glu Thr Gln 
145                 150                 155                 160 


His Val Pro Leu Ser Gln His Met Leu Gly Phe Ala Met Lys Ser Val 
                165                 170                 175     


Thr Gln Met Val Met Gly Ser Thr Phe Glu Asp Asp Gln Glu Val Ile 
            180                 185                 190         


Arg Phe Gln Lys Asn His Gly Thr Val Trp Ser Glu Ile Gly Lys Gly 
        195                 200                 205             


Phe Leu Asp Gly Ser Leu Asp Lys Asn Met Thr Arg Lys Lys Gln Tyr 
    210                 215                 220                 


Glu Asp Ala Leu Met Gln Leu Glu Ser Val Leu Arg Asn Ile Ile Lys 
225                 230                 235                 240 


Glu Arg Lys Gly Arg Asn Phe Ser Gln His Ile Phe Ile Asp Ser Leu 
                245                 250                 255     


Val Gln Gly Asn Leu Asn Asp Gln Gln Ile Leu Glu Asp Ser Met Ile 
            260                 265                 270         


Phe Ser Leu Ala Ser Cys Ile Ile Thr Ala Lys Leu Cys Thr Trp Ala 
        275                 280                 285             


Ile Cys Phe Leu Thr Thr Ser Glu Glu Val Gln Lys Lys Leu Tyr Glu 
    290                 295                 300                 


Glu Ile Asn Gln Val Phe Gly Asn Gly Pro Val Thr Pro Glu Lys Ile 
305                 310                 315                 320 


Glu Gln Leu Arg Tyr Cys Gln His Val Leu Cys Glu Thr Val Arg Thr 
                325                 330                 335     


Ala Lys Leu Thr Pro Val Ser Ala Gln Leu Gln Asp Ile Glu Gly Lys 
            340                 345                 350         


Ile Asp Arg Phe Ile Ile Pro Arg Glu Thr Leu Val Leu Tyr Ala Leu 
        355                 360                 365             


Gly Val Val Leu Gln Asp Pro Asn Thr Trp Pro Ser Pro His Lys Phe 
    370                 375                 380                 


Asp Pro Asp Arg Phe Asp Asp Glu Leu Val Met Lys Thr Phe Ser Ser 
385                 390                 395                 400 


Leu Gly Phe Ser Gly Thr Gln Glu Cys Pro Glu Leu Arg Phe Ala Tyr 
                405                 410                 415     


Met Val Thr Thr Val Leu Leu Ser Val Leu Val Lys Arg Leu His Leu 
            420                 425                 430         


Leu Ser Val Glu Gly Gln Val Ile Glu Thr Lys Tyr Glu Leu Val Thr 
        435                 440                 445             


Ser Ser Arg Glu Glu Ala Trp Ile Thr Val Ser Lys Arg Tyr 
    450                 455                 460         


<210>  3842
<211>  44
<212>  PRT
<213>  Homo Sapiens

<400>  3842

Met Leu Asp Phe Ala Ile Phe Ala Val Thr Phe Leu Leu Ala Leu Val 
1               5                   10                  15      


Gly Ala Val Leu Tyr Leu Tyr Pro Ala Ser Arg Gln Ala Ala Gly Ile 
            20                  25                  30          


Pro Gly Ile Thr Pro Thr Glu Glu Asn Gly Pro Phe 
        35                  40                  


<210>  3843
<211>  44
<212>  PRT
<213>  Homo Sapiens

<400>  3843

Met Leu Asp Phe Ala Ile Phe Ala Val Thr Phe Leu Leu Ala Leu Val 
1               5                   10                  15      


Gly Ala Val Leu Tyr Leu Tyr Pro Ala Ser Arg Gln Ala Ala Gly Ile 
            20                  25                  30          


Pro Gly Ile Thr Pro Thr Glu Glu Asn Gly Pro Phe 
        35                  40                  


<210>  3844
<211>  78
<212>  PRT
<213>  Homo Sapiens

<400>  3844

Met Leu Leu Leu Gly Leu Leu Leu Leu Leu Pro Leu Leu Ala Gly Ala 
1               5                   10                  15      


Arg Leu Leu Trp Asn Trp Trp Lys Leu Arg Ser Leu His Leu Pro Pro 
            20                  25                  30          


Leu Ala Pro Gly Phe Leu His Leu Leu Gln Pro Asp Leu Pro Ile Tyr 
        35                  40                  45              


Leu Leu Gly Leu Thr Gln Lys Phe Gly Pro Ile Tyr Arg Leu His Leu 
    50                  55                  60                  


Gly Leu Gln Ala Pro Thr Ser Ser Cys Arg Gln Ala Gly Val 
65                  70                  75              


<210>  3845
<211>  465
<212>  PRT
<213>  Homo Sapiens

<400>  3845

Met Leu Leu Leu Gly Leu Leu Leu Leu Leu Pro Leu Leu Ala Gly Ala 
1               5                   10                  15      


Arg Leu Leu Trp Asn Trp Trp Lys Leu Arg Ser Leu His Leu Pro Pro 
            20                  25                  30          


Leu Ala Pro Gly Phe Leu His Leu Leu Gln Pro Asp Leu Pro Ile Tyr 
        35                  40                  45              


Leu Leu Gly Leu Thr Gln Lys Phe Gly Pro Ile Tyr Arg Leu His Leu 
    50                  55                  60                  


Gly Leu Gln Asp Lys Leu Val Ser Arg Asn Tyr Pro Asp Leu Ser Leu 
65                  70                  75                  80  


Gly Asp Tyr Ser Leu Leu Trp Lys Ala His Lys Lys Leu Thr Arg Ser 
                85                  90                  95      


Ala Leu Leu Leu Gly Ile Arg Asp Ser Met Glu Pro Val Val Glu Gln 
            100                 105                 110         


Leu Thr Gln Glu Phe Cys Glu Arg Met Arg Ala Gln Pro Gly Thr Pro 
        115                 120                 125             


Val Ala Ile Glu Glu Glu Phe Ser Leu Leu Thr Cys Ser Ile Ile Cys 
    130                 135                 140                 


Tyr Leu Thr Phe Gly Asp Lys Ile Lys Asp Asp Asn Leu Met Pro Ala 
145                 150                 155                 160 


Tyr Tyr Lys Cys Ile Gln Glu Val Leu Lys Thr Trp Ser His Trp Ser 
                165                 170                 175     


Ile Gln Ile Val Asp Val Ile Pro Phe Leu Arg Phe Phe Pro Asn Pro 
            180                 185                 190         


Gly Leu Arg Arg Leu Lys Gln Ala Ile Glu Lys Arg Asp His Ile Val 
        195                 200                 205             


Glu Met Gln Leu Arg Gln His Lys Glu Ser Leu Val Ala Gly Gln Trp 
    210                 215                 220                 


Arg Asp Met Met Asp Tyr Met Leu Gln Gly Val Ala Gln Pro Ser Met 
225                 230                 235                 240 


Glu Glu Gly Ser Gly Gln Leu Leu Glu Gly His Val His Met Ala Ala 
                245                 250                 255     


Val Asp Leu Leu Ile Gly Gly Thr Glu Thr Thr Ala Asn Thr Leu Ser 
            260                 265                 270         


Trp Ala Val Val Phe Leu Leu His His Pro Glu Ile Gln Gln Arg Leu 
        275                 280                 285             


Gln Glu Glu Leu Asp His Glu Leu Gly Pro Gly Ala Ser Ser Ser Arg 
    290                 295                 300                 


Val Pro Tyr Lys Asp Arg Ala Arg Leu Pro Leu Leu Asn Ala Thr Ile 
305                 310                 315                 320 


Ala Glu Val Leu Arg Leu Arg Pro Val Val Pro Leu Ala Leu Pro His 
                325                 330                 335     


Arg Thr Thr Arg Pro Ser Ser Ile Ser Gly Tyr Asp Ile Pro Glu Gly 
            340                 345                 350         


Thr Val Ile Ile Pro Asn Leu Gln Gly Ala His Leu Asp Glu Thr Val 
        355                 360                 365             


Trp Glu Arg Pro His Glu Phe Trp Pro Asp Arg Phe Leu Glu Pro Gly 
    370                 375                 380                 


Lys Asn Ser Arg Ala Leu Ala Phe Gly Cys Gly Ala Arg Val Cys Leu 
385                 390                 395                 400 


Gly Glu Pro Leu Ala Arg Leu Glu Leu Phe Val Val Leu Thr Arg Leu 
                405                 410                 415     


Leu Gln Ala Phe Thr Leu Leu Pro Ser Gly Asp Ala Leu Pro Ser Leu 
            420                 425                 430         


Gln Pro Leu Pro His Cys Ser Val Ile Leu Lys Met Gln Pro Phe Gln 
        435                 440                 445             


Val Arg Leu Gln Pro Arg Gly Met Gly Ala His Ser Pro Gly Gln Ser 
    450                 455                 460                 


Gln 
465 


<210>  3846
<211>  186
<212>  PRT
<213>  Homo Sapiens

<400>  3846

Met Leu Leu Leu Gly Leu Leu Leu Leu Leu Pro Leu Leu Ala Gly Ala 
1               5                   10                  15      


Arg Leu Leu Trp Asn Trp Trp Lys Leu Arg Ser Leu His Leu Pro Pro 
            20                  25                  30          


Leu Ala Pro Gly Phe Leu His Leu Leu Gln Pro Asp Leu Pro Ile Tyr 
        35                  40                  45              


Leu Leu Gly Leu Thr Gln Lys Phe Gly Pro Ile Tyr Arg Leu His Leu 
    50                  55                  60                  


Gly Leu Gln Asp Val Val Val Leu Asn Ser Lys Arg Thr Ile Glu Glu 
65                  70                  75                  80  


Ala Met Val Lys Lys Trp Ala Asp Phe Ala Gly Arg Pro Glu Pro Leu 
                85                  90                  95      


Thr Phe Pro Thr Leu Gln Pro Pro Pro Pro Pro Ala Asp Lys Leu Val 
            100                 105                 110         


Ser Arg Asn Tyr Pro Asp Leu Ser Leu Gly Asp Tyr Ser Leu Leu Trp 
        115                 120                 125             


Lys Ala His Lys Lys Leu Thr Arg Ser Ala Leu Leu Leu Gly Ile Arg 
    130                 135                 140                 


Asp Ser Met Glu Pro Val Val Glu Gln Leu Thr Gln Glu Phe Cys Glu 
145                 150                 155                 160 


Arg Met Arg Ala Gln Pro Gly Thr Pro Val Ala Ile Glu Glu Glu Phe 
                165                 170                 175     


Ser Leu Leu Thr Cys Ser Ile Ile Cys Tyr 
            180                 185     


<210>  3847
<211>  108
<212>  PRT
<213>  Homo Sapiens

<400>  3847

Met Leu Leu Leu Gly Leu Leu Leu Leu Leu Pro Leu Leu Ala Gly Ala 
1               5                   10                  15      


Arg Leu Leu Trp Asn Trp Trp Lys Leu Arg Ser Leu His Leu Pro Pro 
            20                  25                  30          


Leu Ala Pro Gly Phe Leu His Leu Leu Gln Pro Asp Leu Pro Ile Tyr 
        35                  40                  45              


Leu Leu Gly Leu Thr Gln Lys Phe Gly Pro Ile Tyr Arg Leu His Leu 
    50                  55                  60                  


Gly Leu Gln Asp Val Val Val Leu Asn Ser Lys Arg Thr Ile Glu Glu 
65                  70                  75                  80  


Ala Met Val Lys Lys Trp Ala Asp Phe Ala Gly Arg Pro Glu Pro Leu 
                85                  90                  95      


Thr Ser Pro Thr Ser Ser Cys Arg Gln Ala Gly Val 
            100                 105             


<210>  3848
<211>  495
<212>  PRT
<213>  Homo Sapiens

<400>  3848

Met Leu Leu Leu Gly Leu Leu Leu Leu Leu Pro Leu Leu Ala Gly Ala 
1               5                   10                  15      


Arg Leu Leu Trp Asn Trp Trp Lys Leu Arg Ser Leu His Leu Pro Pro 
            20                  25                  30          


Leu Ala Pro Gly Phe Leu His Leu Leu Gln Pro Asp Leu Pro Ile Tyr 
        35                  40                  45              


Leu Leu Gly Leu Thr Gln Lys Phe Gly Pro Ile Tyr Arg Leu His Leu 
    50                  55                  60                  


Gly Leu Gln Asp Val Val Val Leu Asn Ser Lys Arg Thr Ile Glu Glu 
65                  70                  75                  80  


Ala Met Val Lys Lys Trp Ala Asp Phe Ala Gly Arg Pro Glu Pro Leu 
                85                  90                  95      


Thr Tyr Lys Leu Val Ser Arg Asn Tyr Pro Asp Leu Ser Leu Gly Asp 
            100                 105                 110         


Tyr Ser Leu Leu Trp Lys Ala His Lys Lys Leu Thr Arg Ser Ala Leu 
        115                 120                 125             


Leu Leu Gly Ile Arg Asp Ser Met Glu Pro Val Val Glu Gln Leu Thr 
    130                 135                 140                 


Gln Glu Phe Cys Glu Arg Met Arg Ala Gln Pro Gly Thr Pro Val Ala 
145                 150                 155                 160 


Ile Glu Glu Glu Phe Ser Leu Leu Thr Cys Ser Ile Ile Cys Tyr Leu 
                165                 170                 175     


Thr Phe Gly Asp Lys Ile Lys Asp Asp Asn Leu Met Pro Ala Tyr Tyr 
            180                 185                 190         


Lys Cys Ile Gln Glu Val Leu Lys Thr Trp Ser His Trp Ser Ile Gln 
        195                 200                 205             


Ile Val Asp Val Ile Pro Phe Leu Arg Phe Phe Pro Asn Pro Gly Leu 
    210                 215                 220                 


Arg Arg Leu Lys Gln Ala Ile Glu Lys Arg Asp His Ile Val Glu Met 
225                 230                 235                 240 


Gln Leu Arg Gln His Lys Glu Ser Leu Val Ala Gly Gln Trp Arg Asp 
                245                 250                 255     


Met Met Asp Tyr Met Leu Gln Gly Val Ala Gln Pro Ser Met Glu Glu 
            260                 265                 270         


Gly Ser Gly Gln Leu Leu Glu Gly His Val His Met Ala Ala Val Asp 
        275                 280                 285             


Leu Leu Ile Gly Gly Thr Glu Thr Thr Ala Asn Thr Leu Ser Trp Ala 
    290                 295                 300                 


Val Val Phe Leu Leu His His Pro Glu Ile Gln Gln Arg Leu Gln Glu 
305                 310                 315                 320 


Glu Leu Asp His Glu Leu Gly Pro Gly Ala Ser Ser Ser Arg Val Pro 
                325                 330                 335     


Tyr Lys Asp Arg Ala Arg Leu Pro Leu Leu Asn Ala Thr Ile Ala Glu 
            340                 345                 350         


Val Leu Arg Leu Arg Pro Val Val Pro Leu Ala Leu Pro His Arg Thr 
        355                 360                 365             


Thr Arg Pro Ser Ser Ile Ser Gly Tyr Asp Ile Pro Glu Gly Thr Val 
    370                 375                 380                 


Ile Ile Pro Asn Leu Gln Gly Ala His Leu Asp Glu Thr Val Trp Glu 
385                 390                 395                 400 


Arg Pro His Glu Phe Trp Pro Asp Arg Phe Leu Glu Pro Gly Lys Asn 
                405                 410                 415     


Ser Arg Ala Leu Ala Phe Gly Cys Gly Ala Arg Val Cys Leu Gly Glu 
            420                 425                 430         


Pro Leu Ala Arg Leu Glu Leu Phe Val Val Leu Thr Arg Leu Leu Gln 
        435                 440                 445             


Ala Phe Thr Leu Leu Pro Ser Gly Asp Ala Leu Pro Ser Leu Gln Pro 
    450                 455                 460                 


Leu Pro His Cys Ser Val Ile Leu Lys Met Gln Pro Phe Gln Val Arg 
465                 470                 475                 480 


Leu Gln Pro Arg Gly Met Gly Ala His Ser Pro Gly Gln Ser Gln 
                485                 490                 495 


<210>  3849
<211>  495
<212>  PRT
<213>  Homo Sapiens

<400>  3849

Met Leu Leu Leu Gly Leu Leu Leu Leu Leu Pro Leu Leu Ala Gly Ala 
1               5                   10                  15      


Arg Leu Leu Trp Asn Trp Trp Lys Leu Arg Ser Leu His Leu Pro Pro 
            20                  25                  30          


Leu Ala Pro Gly Phe Leu His Leu Leu Gln Pro Asp Leu Pro Ile Tyr 
        35                  40                  45              


Leu Leu Gly Leu Thr Gln Lys Phe Gly Pro Ile Tyr Arg Leu His Leu 
    50                  55                  60                  


Gly Leu Gln Asp Val Val Val Leu Asn Ser Lys Arg Thr Ile Glu Glu 
65                  70                  75                  80  


Ala Met Val Lys Lys Trp Ala Asp Phe Ala Gly Arg Pro Glu Pro Leu 
                85                  90                  95      


Thr Tyr Lys Leu Val Ser Arg Asn Tyr Pro Asp Leu Ser Leu Gly Asp 
            100                 105                 110         


Tyr Ser Leu Leu Trp Lys Ala His Lys Lys Leu Thr Arg Ser Ala Leu 
        115                 120                 125             


Leu Leu Gly Ile Arg Asp Ser Met Glu Pro Val Val Glu Gln Leu Thr 
    130                 135                 140                 


Gln Glu Phe Cys Glu Arg Met Arg Ala Gln Pro Gly Thr Pro Val Ala 
145                 150                 155                 160 


Ile Glu Glu Glu Phe Ser Leu Leu Thr Cys Ser Ile Ile Cys Tyr Leu 
                165                 170                 175     


Thr Phe Gly Asp Lys Ile Lys Asp Asp Asn Leu Met Pro Ala Tyr Tyr 
            180                 185                 190         


Lys Cys Ile Gln Glu Val Leu Lys Thr Trp Ser His Trp Ser Ile Gln 
        195                 200                 205             


Ile Val Asp Val Ile Pro Phe Leu Arg Phe Phe Pro Asn Pro Gly Leu 
    210                 215                 220                 


Arg Arg Leu Lys Gln Ala Ile Glu Lys Arg Asp His Ile Val Glu Met 
225                 230                 235                 240 


Gln Leu Arg Gln His Lys Glu Ser Leu Val Ala Gly Gln Trp Arg Asp 
                245                 250                 255     


Met Met Asp Tyr Met Leu Gln Gly Val Ala Gln Pro Ser Met Glu Glu 
            260                 265                 270         


Gly Ser Gly Gln Leu Leu Glu Gly His Val His Met Ala Ala Val Asp 
        275                 280                 285             


Leu Leu Ile Gly Gly Thr Glu Thr Thr Ala Asn Thr Leu Ser Trp Ala 
    290                 295                 300                 


Val Val Phe Leu Leu His His Pro Glu Ile Gln Gln Arg Leu Gln Glu 
305                 310                 315                 320 


Glu Leu Asp His Glu Leu Gly Pro Gly Ala Ser Ser Ser Arg Val Pro 
                325                 330                 335     


Tyr Lys Asp Arg Ala Arg Leu Pro Leu Leu Asn Ala Thr Ile Ala Glu 
            340                 345                 350         


Val Leu Arg Leu Arg Pro Val Val Pro Leu Ala Leu Pro His Arg Thr 
        355                 360                 365             


Thr Arg Pro Ser Ser Ile Ser Gly Tyr Asp Ile Pro Glu Gly Thr Val 
    370                 375                 380                 


Ile Ile Pro Asn Leu Gln Gly Ala His Leu Asp Glu Thr Val Trp Glu 
385                 390                 395                 400 


Arg Pro His Glu Phe Trp Pro Asp Arg Phe Leu Glu Pro Gly Lys Asn 
                405                 410                 415     


Ser Arg Ala Leu Ala Phe Gly Cys Gly Ala Arg Val Cys Leu Gly Glu 
            420                 425                 430         


Pro Leu Ala Arg Leu Glu Leu Phe Val Val Leu Thr Arg Leu Leu Gln 
        435                 440                 445             


Ala Phe Thr Leu Leu Pro Ser Gly Asp Ala Leu Pro Ser Leu Gln Pro 
    450                 455                 460                 


Leu Pro His Cys Ser Val Ile Leu Lys Met Gln Pro Phe Gln Val Arg 
465                 470                 475                 480 


Leu Gln Pro Arg Gly Met Gly Ala His Ser Pro Gly Gln Ser Gln 
                485                 490                 495 


<210>  3850
<211>  495
<212>  PRT
<213>  Homo Sapiens

<400>  3850

Met Leu Leu Leu Gly Leu Leu Leu Leu Leu Pro Leu Leu Ala Gly Ala 
1               5                   10                  15      


Arg Leu Leu Trp Asn Trp Trp Lys Leu Arg Ser Leu His Leu Pro Pro 
            20                  25                  30          


Leu Ala Pro Gly Phe Leu His Leu Leu Gln Pro Asp Leu Pro Ile Tyr 
        35                  40                  45              


Leu Leu Gly Leu Thr Gln Lys Phe Gly Pro Ile Tyr Arg Leu His Leu 
    50                  55                  60                  


Gly Leu Gln Asp Val Val Val Leu Asn Ser Lys Arg Thr Ile Glu Glu 
65                  70                  75                  80  


Ala Met Val Lys Lys Trp Ala Asp Phe Ala Gly Arg Pro Glu Pro Leu 
                85                  90                  95      


Thr Tyr Lys Leu Val Ser Arg Asn Tyr Pro Asp Leu Ser Leu Gly Asp 
            100                 105                 110         


Tyr Ser Leu Leu Trp Lys Ala His Lys Lys Leu Thr Arg Ser Ala Leu 
        115                 120                 125             


Leu Leu Gly Ile Arg Asp Ser Met Glu Pro Val Val Glu Gln Leu Thr 
    130                 135                 140                 


Gln Glu Phe Cys Glu Arg Met Arg Ala Gln Pro Gly Thr Pro Val Ala 
145                 150                 155                 160 


Ile Glu Glu Glu Phe Ser Leu Leu Thr Cys Ser Ile Ile Cys Tyr Leu 
                165                 170                 175     


Thr Phe Gly Asp Lys Ile Lys Asp Asp Asn Leu Met Pro Ala Tyr Tyr 
            180                 185                 190         


Lys Cys Ile Gln Glu Val Leu Lys Thr Trp Ser His Trp Ser Ile Gln 
        195                 200                 205             


Ile Val Asp Val Ile Pro Phe Leu Arg Phe Phe Pro Asn Pro Gly Leu 
    210                 215                 220                 


Arg Arg Leu Lys Gln Ala Ile Glu Lys Arg Asp His Ile Val Glu Met 
225                 230                 235                 240 


Gln Leu Arg Gln His Lys Glu Ser Leu Val Ala Gly Gln Trp Arg Asp 
                245                 250                 255     


Met Met Asp Tyr Met Leu Gln Gly Val Ala Gln Pro Ser Met Glu Glu 
            260                 265                 270         


Gly Ser Gly Gln Leu Leu Glu Gly His Val His Met Ala Ala Val Asp 
        275                 280                 285             


Leu Leu Ile Gly Gly Thr Glu Thr Thr Ala Asn Thr Leu Ser Trp Ala 
    290                 295                 300                 


Val Val Phe Leu Leu His His Pro Glu Ile Gln Gln Arg Leu Gln Glu 
305                 310                 315                 320 


Glu Leu Asp His Glu Leu Gly Pro Gly Ala Ser Ser Ser Arg Val Pro 
                325                 330                 335     


Tyr Lys Asp Arg Ala Arg Leu Pro Leu Leu Asn Ala Thr Ile Ala Glu 
            340                 345                 350         


Val Leu Arg Leu Arg Pro Val Val Pro Leu Ala Leu Pro His Arg Thr 
        355                 360                 365             


Thr Arg Pro Ser Ser Ile Ser Gly Tyr Asp Ile Pro Glu Gly Thr Val 
    370                 375                 380                 


Ile Ile Pro Asn Leu Gln Gly Ala His Leu Asp Glu Thr Val Trp Glu 
385                 390                 395                 400 


Arg Pro His Glu Phe Trp Pro Asp Arg Phe Leu Glu Pro Gly Lys Asn 
                405                 410                 415     


Ser Arg Ala Leu Ala Phe Gly Cys Gly Ala Arg Val Cys Leu Gly Glu 
            420                 425                 430         


Pro Leu Ala Arg Leu Glu Leu Phe Val Val Leu Thr Arg Leu Leu Gln 
        435                 440                 445             


Ala Phe Thr Leu Leu Pro Ser Gly Asp Ala Leu Pro Ser Leu Gln Pro 
    450                 455                 460                 


Leu Pro His Cys Ser Val Ile Leu Lys Met Gln Pro Phe Gln Val Arg 
465                 470                 475                 480 


Leu Gln Pro Arg Gly Met Gly Ala His Ser Pro Gly Gln Ser Gln 
                485                 490                 495 


<210>  3851
<211>  190
<212>  PRT
<213>  Homo Sapiens

<400>  3851

Met Leu Leu Leu Gly Leu Leu Leu Leu Leu Pro Leu Leu Ala Gly Ala 
1               5                   10                  15      


Arg Leu Leu Trp Asn Trp Trp Lys Leu Arg Ser Leu His Leu Pro Pro 
            20                  25                  30          


Leu Ala Pro Gly Phe Leu His Leu Leu Gln Pro Asp Leu Pro Ile Tyr 
        35                  40                  45              


Leu Leu Gly Leu Thr Gln Lys Phe Gly Pro Ile Tyr Arg Leu His Leu 
    50                  55                  60                  


Gly Leu Gln Asp Val Val Val Leu Asn Ser Lys Arg Thr Ile Glu Glu 
65                  70                  75                  80  


Ala Met Val Lys Lys Trp Ala Asp Phe Ala Gly Arg Pro Glu Pro Leu 
                85                  90                  95      


Thr Tyr Lys Leu Val Ser Arg Asn Tyr Pro Asp Leu Ser Leu Gly Asp 
            100                 105                 110         


Tyr Ser Leu Leu Trp Lys Ala His Lys Lys Leu Thr Arg Ser Ala Leu 
        115                 120                 125             


Leu Leu Gly Ile Arg Asp Ser Met Glu Pro Val Val Glu Gln Leu Thr 
    130                 135                 140                 


Gln Glu Phe Cys Glu Arg Met Arg Ala Gln Pro Gly Thr Pro Val Ala 
145                 150                 155                 160 


Ile Glu Glu Glu Phe Ser Leu Leu Thr Cys Ser Ile Ile Cys Tyr Leu 
                165                 170                 175     


Thr Phe Gly Asp Lys Ile Lys Glu Val Leu Lys Thr Trp Ser 
            180                 185                 190 


<210>  3852
<211>  321
<212>  PRT
<213>  Homo Sapiens

<400>  3852

Met Ala Ile Arg Val Leu Leu Gly Phe Ser Ile Pro Glu Glu Asp Leu 
1               5                   10                  15      


Gly His Leu Phe Glu Val Tyr Gln Gln Phe Val Asp Asn Val Phe Ser 
            20                  25                  30          


Leu Pro Val Asp Leu Pro Phe Ser Gly Tyr Arg Arg Gly Ile Gln Ala 
        35                  40                  45              


Arg Gln Ile Leu Gln Lys Gly Leu Glu Lys Ala Ile Arg Glu Lys Leu 
    50                  55                  60                  


Gln Cys Thr Gln Gly Lys Asp Tyr Leu Asp Ala Leu Asp Leu Leu Ile 
65                  70                  75                  80  


Glu Ser Ser Lys Glu His Gly Lys Glu Met Thr Met Gln Glu Leu Lys 
                85                  90                  95      


Asp Gly Thr Leu Glu Leu Ile Phe Ala Ala Tyr Ala Thr Thr Ala Ser 
            100                 105                 110         


Ala Ser Thr Ser Leu Ile Met Gln Leu Leu Lys His Pro Thr Val Leu 
        115                 120                 125             


Glu Lys Leu Arg Asp Glu Leu Arg Ala His Gly Ile Leu His Ser Gly 
    130                 135                 140                 


Gly Cys Pro Cys Glu Gly Thr Leu Arg Leu Asp Thr Leu Ser Gly Leu 
145                 150                 155                 160 


Arg Tyr Leu Asp Cys Val Ile Lys Glu Val Met Arg Leu Phe Thr Pro 
                165                 170                 175     


Ile Ser Gly Gly Tyr Arg Thr Val Leu Gln Thr Phe Glu Leu Asp Gly 
            180                 185                 190         


Phe Gln Ile Pro Lys Gly Trp Ser Val Met Tyr Ser Ile Arg Asp Thr 
        195                 200                 205             


His Asp Thr Ala Pro Val Phe Lys Asp Val Asn Val Phe Asp Pro Asp 
    210                 215                 220                 


Arg Phe Ser Gln Ala Arg Ser Glu Asp Lys Asp Gly Arg Phe His Tyr 
225                 230                 235                 240 


Leu Pro Phe Gly Gly Gly Val Arg Thr Cys Leu Gly Lys His Leu Ala 
                245                 250                 255     


Lys Leu Phe Leu Lys Val Leu Ala Val Glu Leu Ala Ser Thr Ser Arg 
            260                 265                 270         


Phe Glu Leu Ala Thr Arg Thr Phe Pro Arg Ile Thr Leu Val Pro Val 
        275                 280                 285             


Leu His Pro Val Asp Gly Leu Ser Val Lys Phe Phe Gly Leu Asp Ser 
    290                 295                 300                 


Asn Gln Asn Glu Ile Leu Pro Glu Thr Glu Ala Met Leu Ser Ala Thr 
305                 310                 315                 320 


Val 
    


<210>  3853
<211>  172
<212>  PRT
<213>  Homo Sapiens

<400>  3853

Met Lys Asn Lys Thr Cys Val Leu Val Cys Val Ser Val Phe Gly Gly 
1               5                   10                  15      


Glu Arg Gly Gln Val Thr Val Pro Arg Val Gly Val Arg Arg Pro Ser 
            20                  25                  30          


Leu Ala Gly Pro Leu Gln Lys Cys Thr Leu Arg Glu Thr Arg Val Trp 
        35                  40                  45              


Leu Pro Gln Gly Ser Gly Phe Gln Ser Ser Arg Arg Glu Lys Tyr Gly 
    50                  55                  60                  


Asn Val Phe Lys Thr His Leu Leu Gly Arg Pro Leu Ile Arg Val Thr 
65                  70                  75                  80  


Gly Ala Glu Asn Val Arg Lys Ile Leu Met Gly Glu His His Leu Val 
                85                  90                  95      


Ser Thr Glu Trp Pro Arg Ser Thr Arg Met Leu Leu Gly Pro Asn Thr 
            100                 105                 110         


Val Ser Asn Ser Ile Gly Asp Ile His Arg Asn Lys Arg Lys Val Phe 
        115                 120                 125             


Ser Lys Ile Phe Ser His Glu Ala Leu Glu Ser Tyr Leu Pro Lys Ile 
    130                 135                 140                 


Gln Leu Val Ile Gln Asp Thr Leu Arg Ala Trp Ser Ser His Pro Glu 
145                 150                 155                 160 


Ala Ile Asn Val Tyr Gln Glu Ala Gln Lys Leu Thr 
                165                 170         


<210>  3854
<211>  512
<212>  PRT
<213>  Homo Sapiens

<400>  3854

Met Leu Phe Glu Gly Leu Asp Leu Val Ser Ala Leu Ala Thr Leu Ala 
1               5                   10                  15      


Ala Cys Leu Val Ser Val Thr Leu Leu Leu Ala Val Ser Gln Gln Leu 
            20                  25                  30          


Trp Gln Leu Arg Trp Ala Ala Thr Arg Asp Lys Ser Cys Lys Leu Pro 
        35                  40                  45              


Ile Pro Lys Gly Ser Met Gly Phe Pro Leu Ile Gly Glu Thr Gly His 
    50                  55                  60                  


Trp Leu Leu Gln Gly Ser Gly Phe Gln Ser Ser Arg Arg Glu Lys Tyr 
65                  70                  75                  80  


Gly Asn Val Phe Lys Thr His Leu Leu Gly Arg Pro Leu Ile Arg Val 
                85                  90                  95      


Thr Gly Ala Glu Asn Val Arg Lys Ile Leu Met Gly Glu His His Leu 
            100                 105                 110         


Val Ser Thr Glu Trp Pro Arg Ser Thr Arg Met Leu Leu Gly Pro Asn 
        115                 120                 125             


Thr Val Ser Asn Ser Ile Gly Asp Ile His Arg Asn Lys Arg Lys Val 
    130                 135                 140                 


Phe Ser Lys Ile Phe Ser His Glu Ala Leu Glu Ser Tyr Leu Pro Lys 
145                 150                 155                 160 


Ile Gln Leu Val Ile Gln Asp Thr Leu Arg Ala Trp Ser Ser His Pro 
                165                 170                 175     


Glu Ala Ile Asn Val Tyr Gln Glu Ala Gln Lys Leu Thr Phe Arg Met 
            180                 185                 190         


Ala Ile Arg Val Leu Leu Gly Phe Ser Ile Pro Glu Glu Asp Leu Gly 
        195                 200                 205             


His Leu Phe Glu Val Tyr Gln Gln Phe Val Asp Asn Val Phe Ser Leu 
    210                 215                 220                 


Pro Val Asp Leu Pro Phe Ser Gly Tyr Arg Arg Gly Ile Gln Ala Arg 
225                 230                 235                 240 


Gln Ile Leu Gln Lys Gly Leu Glu Lys Ala Ile Arg Glu Lys Leu Gln 
                245                 250                 255     


Cys Thr Gln Gly Lys Asp Tyr Leu Asp Ala Leu Asp Leu Leu Ile Glu 
            260                 265                 270         


Ser Ser Lys Glu His Gly Lys Glu Met Thr Met Gln Glu Leu Lys Asp 
        275                 280                 285             


Gly Thr Leu Glu Leu Ile Phe Ala Ala Tyr Ala Thr Thr Ala Ser Ala 
    290                 295                 300                 


Ser Thr Ser Leu Ile Met Gln Leu Leu Lys His Pro Thr Val Leu Glu 
305                 310                 315                 320 


Lys Leu Arg Asp Glu Leu Arg Ala His Gly Ile Leu His Ser Gly Gly 
                325                 330                 335     


Cys Pro Cys Glu Gly Thr Leu Arg Leu Asp Thr Leu Ser Gly Leu Arg 
            340                 345                 350         


Tyr Leu Asp Cys Val Ile Lys Glu Val Met Arg Leu Phe Thr Pro Ile 
        355                 360                 365             


Ser Gly Gly Tyr Arg Thr Val Leu Gln Thr Phe Glu Leu Asp Gly Phe 
    370                 375                 380                 


Gln Ile Pro Lys Gly Trp Ser Val Met Tyr Ser Ile Arg Asp Thr His 
385                 390                 395                 400 


Asp Thr Ala Pro Val Phe Lys Asp Val Asn Val Phe Asp Pro Asp Arg 
                405                 410                 415     


Phe Ser Gln Ala Arg Ser Glu Asp Lys Asp Gly Arg Phe His Tyr Leu 
            420                 425                 430         


Pro Phe Gly Gly Gly Val Arg Thr Cys Leu Gly Lys His Leu Ala Lys 
        435                 440                 445             


Leu Phe Leu Lys Val Leu Ala Val Glu Leu Ala Ser Thr Ser Arg Phe 
    450                 455                 460                 


Glu Leu Ala Thr Arg Thr Phe Pro Arg Ile Thr Leu Val Pro Val Leu 
465                 470                 475                 480 


His Pro Val Asp Gly Leu Ser Val Lys Phe Phe Gly Leu Asp Ser Asn 
                485                 490                 495     


Gln Asn Glu Ile Leu Pro Glu Thr Glu Ala Met Leu Ser Ala Thr Val 
            500                 505                 510         


<210>  3855
<211>  182
<212>  PRT
<213>  Homo Sapiens

<400>  3855

Met Leu Phe Glu Gly Leu Asp Leu Val Ser Ala Leu Ala Thr Leu Ala 
1               5                   10                  15      


Ala Cys Leu Val Ser Val Thr Leu Leu Leu Ala Val Ser Gln Gln Leu 
            20                  25                  30          


Trp Gln Leu Arg Trp Ala Ala Thr Arg Asp Lys Ser Cys Lys Leu Pro 
        35                  40                  45              


Ile Pro Lys Gly Ser Met Gly Phe Pro Leu Ile Gly Glu Thr Gly His 
    50                  55                  60                  


Trp Leu Leu Gln Val Phe Ser Lys Ile Phe Ser His Glu Ala Leu Glu 
65                  70                  75                  80  


Ser Tyr Leu Pro Lys Ile Gln Leu Val Ile Gln Asp Thr Leu Arg Ala 
                85                  90                  95      


Trp Ser Ser His Pro Glu Ala Ile Asn Val Tyr Gln Glu Ala Gln Lys 
            100                 105                 110         


Leu Thr Phe Arg Met Ala Ile Arg Val Leu Leu Gly Phe Ser Ile Pro 
        115                 120                 125             


Glu Glu Asp Leu Gly His Leu Phe Glu Val Tyr Gln Gln Phe Val Asp 
    130                 135                 140                 


Asn Val Phe Ser Leu Pro Val Asp Leu Pro Phe Ser Gly Tyr Arg Arg 
145                 150                 155                 160 


Gly Ile Gln Ala Arg Gln Ile Leu Gln Lys Gly Leu Glu Lys Ala Ile 
                165                 170                 175     


Arg Glu Lys Leu Gln Cys 
            180         


<210>  3856
<211>  437
<212>  PRT
<213>  Homo Sapiens

<400>  3856

Met Leu Phe Glu Gly Leu Asp Leu Val Ser Ala Leu Ala Thr Leu Ala 
1               5                   10                  15      


Ala Cys Leu Val Ser Val Thr Leu Leu Leu Ala Val Ser Gln Gln Leu 
            20                  25                  30          


Trp Gln Leu Arg Trp Ala Ala Thr Arg Asp Lys Ser Cys Lys Leu Pro 
        35                  40                  45              


Ile Pro Lys Gly Ser Met Gly Phe Pro Leu Ile Gly Glu Thr Gly His 
    50                  55                  60                  


Trp Leu Leu Gln Val Phe Ser Lys Ile Phe Ser His Glu Ala Leu Glu 
65                  70                  75                  80  


Ser Tyr Leu Pro Lys Ile Gln Leu Val Ile Gln Asp Thr Leu Arg Ala 
                85                  90                  95      


Trp Ser Ser His Pro Glu Ala Ile Asn Val Tyr Gln Glu Ala Gln Lys 
            100                 105                 110         


Leu Thr Phe Arg Met Ala Ile Arg Val Leu Leu Gly Phe Ser Ile Pro 
        115                 120                 125             


Glu Glu Asp Leu Gly His Leu Phe Glu Val Tyr Gln Gln Phe Val Asp 
    130                 135                 140                 


Asn Val Phe Ser Leu Pro Val Asp Leu Pro Phe Ser Gly Tyr Arg Arg 
145                 150                 155                 160 


Gly Ile Gln Ala Arg Gln Ile Leu Gln Lys Gly Leu Glu Lys Ala Ile 
                165                 170                 175     


Arg Glu Lys Leu Gln Cys Thr Gln Gly Lys Asp Tyr Leu Asp Ala Leu 
            180                 185                 190         


Asp Leu Leu Ile Glu Ser Ser Lys Glu His Gly Lys Glu Met Thr Met 
        195                 200                 205             


Gln Glu Leu Lys Asp Gly Thr Leu Glu Leu Ile Phe Ala Ala Tyr Ala 
    210                 215                 220                 


Thr Thr Ala Ser Ala Ser Thr Ser Leu Ile Met Gln Leu Leu Lys His 
225                 230                 235                 240 


Pro Thr Val Leu Glu Lys Leu Arg Asp Glu Leu Arg Ala His Gly Ile 
                245                 250                 255     


Leu His Ser Gly Gly Cys Pro Cys Glu Gly Thr Leu Arg Leu Asp Thr 
            260                 265                 270         


Leu Ser Gly Leu Arg Tyr Leu Asp Cys Val Ile Lys Glu Val Met Arg 
        275                 280                 285             


Leu Phe Thr Pro Ile Ser Gly Gly Tyr Arg Thr Val Leu Gln Thr Phe 
    290                 295                 300                 


Glu Leu Asp Gly Phe Gln Ile Pro Lys Gly Trp Ser Val Met Tyr Ser 
305                 310                 315                 320 


Ile Arg Asp Thr His Asp Thr Ala Pro Val Phe Lys Asp Val Asn Val 
                325                 330                 335     


Phe Asp Pro Asp Arg Phe Ser Gln Ala Arg Ser Glu Asp Lys Asp Gly 
            340                 345                 350         


Arg Phe His Tyr Leu Pro Phe Gly Gly Gly Val Arg Thr Cys Leu Gly 
        355                 360                 365             


Lys His Leu Ala Lys Leu Phe Leu Lys Val Leu Ala Val Glu Leu Ala 
    370                 375                 380                 


Ser Thr Ser Arg Phe Glu Leu Ala Thr Arg Thr Phe Pro Arg Ile Thr 
385                 390                 395                 400 


Leu Val Pro Val Leu His Pro Val Asp Gly Leu Ser Val Lys Phe Phe 
                405                 410                 415     


Gly Leu Asp Ser Asn Gln Asn Glu Ile Leu Pro Glu Thr Glu Ala Met 
            420                 425                 430         


Leu Ser Ala Thr Val 
        435         


<210>  3857
<211>  494
<212>  PRT
<213>  Homo Sapiens

<400>  3857

Met Leu Ala Ser Gly Met Leu Leu Val Ala Leu Leu Val Cys Leu Thr 
1               5                   10                  15      


Val Met Val Leu Met Ser Val Trp Gln Gln Arg Lys Ser Lys Gly Lys 
            20                  25                  30          


Leu Pro Pro Gly Pro Thr Pro Leu Pro Phe Ile Gly Asn Tyr Leu Gln 
        35                  40                  45              


Leu Asn Thr Glu Gln Met Tyr Asn Ser Leu Met Lys Ile Ser Glu Arg 
    50                  55                  60                  


Tyr Gly Pro Val Phe Thr Ile His Leu Gly Pro Arg Arg Val Val Val 
65                  70                  75                  80  


Leu Cys Gly His Asp Ala Val Arg Glu Ala Leu Val Asp Gln Ala Glu 
                85                  90                  95      


Glu Phe Ser Gly Arg Gly Glu Gln Ala Thr Phe Asp Trp Val Phe Lys 
            100                 105                 110         


Gly Tyr Gly Val Val Phe Ser Asn Gly Glu Arg Ala Lys Gln Leu Arg 
        115                 120                 125             


Arg Phe Ser Ile Ala Thr Leu Arg Asp Phe Gly Val Gly Lys Arg Gly 
    130                 135                 140                 


Ile Glu Glu Arg Ile Gln Glu Glu Ala Gly Phe Leu Ile Asp Ala Leu 
145                 150                 155                 160 


Arg Gly Thr Gly Gly Ala Asn Ile Asp Pro Thr Phe Phe Leu Ser Arg 
                165                 170                 175     


Thr Val Ser Asn Val Ile Ser Ser Ile Val Phe Gly Asp Arg Phe Asp 
            180                 185                 190         


Tyr Lys Asp Lys Glu Phe Leu Ser Leu Leu Arg Met Met Leu Gly Ile 
        195                 200                 205             


Phe Gln Phe Thr Ser Thr Ser Thr Gly Gln Leu Tyr Glu Met Phe Ser 
    210                 215                 220                 


Ser Val Met Lys His Leu Pro Gly Pro Gln Gln Gln Ala Phe Gln Leu 
225                 230                 235                 240 


Leu Gln Gly Leu Glu Asp Phe Ile Ala Lys Lys Val Glu His Asn Gln 
                245                 250                 255     


Arg Thr Leu Asp Pro Asn Ser Pro Arg Asp Phe Ile Asp Ser Phe Leu 
            260                 265                 270         


Ile Arg Met Gln Glu Glu Glu Lys Asn Pro Asn Thr Glu Phe Tyr Leu 
        275                 280                 285             


Lys Asn Leu Val Met Thr Thr Leu Asn Leu Phe Ile Gly Gly Thr Glu 
    290                 295                 300                 


Thr Val Ser Thr Thr Leu Arg Tyr Gly Phe Leu Leu Leu Met Lys His 
305                 310                 315                 320 


Pro Glu Val Glu Ala Lys Val His Glu Glu Ile Asp Arg Val Ile Gly 
                325                 330                 335     


Lys Asn Arg Gln Pro Lys Phe Glu Asp Arg Ala Lys Met Pro Tyr Met 
            340                 345                 350         


Glu Ala Val Ile His Glu Ile Gln Arg Phe Gly Asp Val Ile Pro Met 
        355                 360                 365             


Ser Leu Ala Arg Arg Val Lys Lys Asp Thr Lys Phe Arg Asp Phe Phe 
    370                 375                 380                 


Leu Pro Lys Gly Thr Glu Val Tyr Pro Met Leu Gly Ser Val Leu Arg 
385                 390                 395                 400 


Asp Pro Ser Phe Phe Ser Asn Pro Gln Asp Phe Asn Pro Gln His Phe 
                405                 410                 415     


Leu Asn Glu Lys Gly Gln Phe Lys Lys Ser Asp Ala Phe Val Pro Phe 
            420                 425                 430         


Ser Ile Gly Lys Arg Asn Cys Phe Gly Glu Gly Leu Ala Arg Met Glu 
        435                 440                 445             


Leu Phe Leu Phe Phe Thr Thr Val Met Gln Asn Phe Arg Leu Lys Ser 
    450                 455                 460                 


Ser Gln Ser Pro Lys Asp Ile Asp Val Ser Pro Lys His Val Gly Phe 
465                 470                 475                 480 


Ala Thr Ile Pro Arg Asn Tyr Thr Met Ser Phe Leu Pro Arg 
                485                 490                 


<210>  3858
<211>  65
<212>  PRT
<213>  Homo Sapiens

<400>  3858

Met Leu Ala Ser Gly Met Leu Leu Val Ala Leu Leu Val Cys Leu Thr 
1               5                   10                  15      


Val Met Val Leu Met Ser Val Trp Gln Gln Arg Lys Ser Lys Gly Lys 
            20                  25                  30          


Leu Pro Pro Gly Pro Thr Pro Leu Pro Phe Ile Gly Asn Tyr Leu Gln 
        35                  40                  45              


Leu Asn Thr Glu Gln Met Tyr Asn Ser Leu Met Lys Val Ser Gln Asp 
    50                  55                  60                  


Gln 
65  


<210>  3859
<211>  80
<212>  PRT
<213>  Homo Sapiens

<400>  3859

Met Leu Ala Ser Gly Leu Leu Leu Val Ala Leu Leu Ala Cys Leu Thr 
1               5                   10                  15      


Val Met Val Leu Met Ser Val Trp Gln Gln Arg Lys Ser Arg Gly Lys 
            20                  25                  30          


Leu Pro Pro Gly Pro Thr Pro Leu Pro Phe Ile Gly Asn Tyr Leu Gln 
        35                  40                  45              


Leu Asn Thr Glu His Ile Cys Asp Ser Ile Met Lys Ala Trp Arg Ser 
    50                  55                  60                  


Ala Thr Gly Ser Ala Pro Ser Ser Ser Cys Ala Leu Pro Ser Pro Pro 
65                  70                  75                  80  


<210>  3860
<211>  494
<212>  PRT
<213>  Homo Sapiens

<400>  3860

Met Leu Ala Ser Gly Leu Leu Leu Val Ala Leu Leu Ala Cys Leu Thr 
1               5                   10                  15      


Val Met Val Leu Met Ser Val Trp Gln Gln Arg Lys Ser Arg Gly Lys 
            20                  25                  30          


Leu Pro Pro Gly Pro Thr Pro Leu Pro Phe Ile Gly Asn Tyr Leu Gln 
        35                  40                  45              


Leu Asn Thr Glu His Ile Cys Asp Ser Ile Met Lys Phe Ser Glu Cys 
    50                  55                  60                  


Tyr Gly Pro Val Phe Thr Ile His Leu Gly Pro Arg Arg Val Val Val 
65                  70                  75                  80  


Leu Cys Gly His Asp Ala Val Arg Glu Ala Leu Val Asp Gln Ala Glu 
                85                  90                  95      


Glu Phe Ser Gly Arg Gly Glu Gln Ala Thr Phe Asp Trp Val Phe Lys 
            100                 105                 110         


Gly Tyr Gly Val Ala Phe Ser Asn Gly Glu Arg Ala Lys Gln Leu Leu 
        115                 120                 125             


Arg Phe Ala Ile Ala Thr Leu Arg Asp Phe Gly Val Gly Lys Arg Gly 
    130                 135                 140                 


Ile Glu Glu Arg Ile Gln Glu Glu Ser Gly Phe Leu Ile Glu Ala Ile 
145                 150                 155                 160 


Arg Ser Thr His Gly Ala Asn Ile Asp Pro Thr Phe Phe Leu Ser Arg 
                165                 170                 175     


Thr Val Ser Asn Val Ile Ser Ser Ile Val Phe Gly Asp Arg Phe Asp 
            180                 185                 190         


Tyr Glu Asp Lys Glu Phe Leu Ser Leu Leu Ser Met Met Leu Gly Ile 
        195                 200                 205             


Phe Gln Phe Thr Ser Thr Ser Thr Gly Gln Leu Tyr Glu Met Phe Ser 
    210                 215                 220                 


Ser Val Met Lys His Leu Pro Gly Pro Gln Gln Gln Ala Phe Lys Leu 
225                 230                 235                 240 


Leu Gln Gly Leu Glu Asp Phe Ile Ala Lys Lys Val Glu His Asn Gln 
                245                 250                 255     


Arg Thr Leu Asp Pro Asn Ser Pro Gln Asp Phe Ile Asp Ser Phe Leu 
            260                 265                 270         


Ile His Met Gln Glu Glu Glu Lys Asn Pro Asn Thr Glu Phe Tyr Leu 
        275                 280                 285             


Lys Asn Leu Met Met Ser Thr Leu Asn Leu Phe Ile Ala Gly Thr Glu 
    290                 295                 300                 


Thr Val Ser Thr Thr Leu Arg Tyr Gly Phe Leu Leu Leu Met Lys His 
305                 310                 315                 320 


Pro Glu Val Glu Ala Lys Val His Glu Glu Ile Asp Arg Val Ile Gly 
                325                 330                 335     


Lys Asn Arg Gln Pro Lys Phe Glu Asp Arg Thr Lys Met Pro Tyr Met 
            340                 345                 350         


Glu Ala Val Ile His Glu Ile Gln Arg Phe Gly Asp Val Ile Pro Met 
        355                 360                 365             


Ser Leu Ala Arg Arg Val Lys Lys Asp Thr Lys Phe Arg Asp Phe Phe 
    370                 375                 380                 


Leu Pro Lys Gly Thr Glu Val Phe Pro Met Leu Gly Ser Val Leu Arg 
385                 390                 395                 400 


Asp Pro Ser Phe Phe Ser Asn Pro Gln Asp Phe Asn Pro Gln His Phe 
                405                 410                 415     


Leu Asp Asp Lys Gly Gln Phe Lys Lys Ser Asp Ala Phe Val Pro Phe 
            420                 425                 430         


Ser Ile Gly Lys Arg Asn Cys Phe Gly Glu Gly Leu Ala Arg Met Glu 
        435                 440                 445             


Leu Phe Leu Phe Phe Thr Thr Val Met Gln Asn Phe Arg Leu Lys Ser 
    450                 455                 460                 


Ser Gln Ser Pro Lys Asp Ile Asp Val Ser Pro Lys His Val Val Phe 
465                 470                 475                 480 


Ala Thr Ile Pro Arg Asn Tyr Thr Met Ser Phe Leu Pro Arg 
                485                 490                 


<210>  3861
<211>  443
<212>  PRT
<213>  Homo Sapiens

<400>  3861

Met Leu Ala Ser Gly Leu Leu Leu Val Ala Leu Leu Ala Cys Leu Thr 
1               5                   10                  15      


Val Met Val Leu Met Ser Val Trp Gln Gln Arg Lys Ser Arg Gly Lys 
            20                  25                  30          


Leu Pro Pro Gly Pro Thr Pro Leu Pro Phe Ile Gly Asn Tyr Leu Gln 
        35                  40                  45              


Leu Asn Thr Glu His Ile Cys Asp Ser Ile Met Lys Val Ser Gln Gly 
    50                  55                  60                  


Val Ala Phe Ser Asn Gly Glu Arg Ala Lys Gln Leu Leu Arg Phe Ala 
65                  70                  75                  80  


Ile Ala Thr Leu Arg Asp Phe Gly Val Gly Lys Arg Gly Ile Glu Glu 
                85                  90                  95      


Arg Ile Gln Glu Glu Ser Gly Phe Leu Ile Glu Ala Ile Arg Ser Thr 
            100                 105                 110         


His Gly Ala Asn Ile Asp Pro Thr Phe Phe Leu Ser Arg Thr Val Ser 
        115                 120                 125             


Asn Val Ile Ser Ser Ile Val Phe Gly Asp Arg Phe Asp Tyr Glu Asp 
    130                 135                 140                 


Lys Glu Phe Leu Ser Leu Leu Ser Met Met Leu Gly Ile Phe Gln Phe 
145                 150                 155                 160 


Thr Ser Thr Ser Thr Gly Gln Leu Tyr Glu Met Phe Ser Ser Val Met 
                165                 170                 175     


Lys His Leu Pro Gly Pro Gln Gln Gln Ala Phe Lys Leu Leu Gln Gly 
            180                 185                 190         


Leu Glu Asp Phe Ile Ala Lys Lys Val Glu His Asn Gln Arg Thr Leu 
        195                 200                 205             


Asp Pro Asn Ser Pro Gln Asp Phe Ile Asp Ser Phe Leu Ile His Met 
    210                 215                 220                 


Gln Glu Glu Glu Lys Asn Pro Asn Thr Glu Phe Tyr Leu Lys Asn Leu 
225                 230                 235                 240 


Met Met Ser Thr Leu Asn Leu Phe Ile Ala Gly Thr Glu Thr Val Ser 
                245                 250                 255     


Thr Thr Leu Arg Tyr Gly Phe Leu Leu Leu Met Lys His Pro Glu Val 
            260                 265                 270         


Glu Ala Lys Val His Glu Glu Ile Asp Arg Val Ile Gly Lys Asn Arg 
        275                 280                 285             


Gln Pro Lys Phe Glu Asp Arg Thr Lys Met Pro Tyr Met Glu Ala Val 
    290                 295                 300                 


Ile His Glu Ile Gln Arg Phe Gly Asp Val Ile Pro Met Ser Leu Ala 
305                 310                 315                 320 


Arg Arg Val Lys Lys Asp Thr Lys Phe Arg Asp Phe Phe Leu Pro Lys 
                325                 330                 335     


Gly Thr Glu Val Phe Pro Met Leu Gly Ser Val Leu Arg Asp Pro Ser 
            340                 345                 350         


Phe Phe Ser Asn Pro Gln Asp Phe Asn Pro Gln His Phe Leu Asp Asp 
        355                 360                 365             


Lys Gly Gln Phe Lys Lys Ser Asp Ala Phe Val Pro Phe Ser Ile Gly 
    370                 375                 380                 


Lys Arg Asn Cys Phe Gly Glu Gly Leu Ala Arg Met Glu Leu Phe Leu 
385                 390                 395                 400 


Phe Phe Thr Thr Val Met Gln Asn Phe Arg Leu Lys Ser Ser Gln Ser 
                405                 410                 415     


Pro Lys Asp Ile Asp Val Ser Pro Lys His Val Val Phe Ala Thr Ile 
            420                 425                 430         


Pro Arg Asn Tyr Thr Met Ser Phe Leu Pro Arg 
        435                 440             


<210>  3862
<211>  491
<212>  PRT
<213>  Homo Sapiens

<400>  3862

Met Glu Leu Ser Val Leu Leu Phe Leu Ala Leu Leu Thr Gly Leu Leu 
1               5                   10                  15      


Leu Leu Leu Val Gln Arg His Pro Asn Thr His Asp Arg Leu Pro Pro 
            20                  25                  30          


Gly Pro Arg Pro Leu Pro Leu Leu Gly Asn Leu Leu Gln Met Asp Arg 
        35                  40                  45              


Arg Gly Leu Leu Lys Ser Phe Leu Arg Phe Arg Glu Lys Tyr Gly Asp 
    50                  55                  60                  


Val Phe Thr Val His Leu Gly Pro Arg Pro Val Val Met Leu Cys Gly 
65                  70                  75                  80  


Val Glu Ala Ile Arg Glu Ala Leu Val Asp Lys Ala Glu Ala Phe Ser 
                85                  90                  95      


Gly Arg Gly Lys Ile Ala Met Val Asp Pro Phe Phe Arg Gly Tyr Gly 
            100                 105                 110         


Val Ile Phe Ala Asn Gly Asn Arg Trp Lys Val Leu Arg Arg Phe Ser 
        115                 120                 125             


Val Thr Thr Met Arg Asp Phe Gly Met Gly Lys Arg Ser Val Glu Glu 
    130                 135                 140                 


Arg Ile Gln Glu Glu Ala Gln Cys Leu Ile Glu Glu Leu Arg Lys Ser 
145                 150                 155                 160 


Lys Gly Ala Leu Met Asp Pro Thr Phe Leu Phe Gln Ser Ile Thr Ala 
                165                 170                 175     


Asn Ile Ile Cys Ser Ile Val Phe Gly Lys Arg Phe His Tyr Gln Asp 
            180                 185                 190         


Gln Glu Phe Leu Lys Met Leu Asn Leu Phe Tyr Gln Thr Phe Ser Leu 
        195                 200                 205             


Ile Ser Ser Val Phe Gly Gln Leu Phe Glu Leu Phe Ser Gly Phe Leu 
    210                 215                 220                 


Lys Tyr Phe Pro Gly Ala His Arg Gln Val Tyr Lys Asn Leu Gln Glu 
225                 230                 235                 240 


Ile Asn Ala Tyr Ile Gly His Ser Val Glu Lys His Arg Glu Thr Leu 
                245                 250                 255     


Asp Pro Ser Ala Pro Lys Asp Leu Ile Asp Thr Tyr Leu Leu His Met 
            260                 265                 270         


Glu Lys Glu Lys Ser Asn Ala His Ser Glu Phe Ser His Gln Asn Leu 
        275                 280                 285             


Asn Leu Asn Thr Leu Ser Leu Phe Phe Ala Gly Thr Glu Thr Thr Ser 
    290                 295                 300                 


Thr Thr Leu Arg Tyr Gly Phe Leu Leu Met Leu Lys Tyr Pro His Val 
305                 310                 315                 320 


Ala Glu Arg Val Tyr Arg Glu Ile Glu Gln Val Ile Gly Pro His Arg 
                325                 330                 335     


Pro Pro Glu Leu His Asp Arg Ala Lys Met Pro Tyr Thr Glu Ala Val 
            340                 345                 350         


Ile Tyr Glu Ile Gln Arg Phe Ser Asp Leu Leu Pro Met Gly Val Pro 
        355                 360                 365             


His Ile Val Thr Gln His Thr Ser Phe Arg Gly Tyr Ile Ile Pro Lys 
    370                 375                 380                 


Asp Thr Glu Val Phe Leu Ile Leu Ser Thr Ala Leu His Asp Pro His 
385                 390                 395                 400 


Tyr Phe Glu Lys Pro Asp Ala Phe Asn Pro Asp His Phe Leu Asp Ala 
                405                 410                 415     


Asn Gly Ala Leu Lys Lys Thr Glu Ala Phe Ile Pro Phe Ser Leu Gly 
            420                 425                 430         


Lys Arg Ile Cys Leu Gly Glu Gly Ile Ala Arg Ala Glu Leu Phe Leu 
        435                 440                 445             


Phe Phe Thr Thr Ile Leu Gln Asn Phe Ser Met Ala Ser Pro Val Ala 
    450                 455                 460                 


Pro Glu Asp Ile Asp Leu Thr Pro Gln Glu Cys Gly Val Gly Lys Ile 
465                 470                 475                 480 


Pro Pro Thr Tyr Gln Ile Arg Phe Leu Pro Arg 
                485                 490     


<210>  3863
<211>  491
<212>  PRT
<213>  Homo Sapiens

<400>  3863

Met Glu Leu Ser Val Leu Leu Phe Leu Ala Leu Leu Thr Gly Leu Leu 
1               5                   10                  15      


Leu Leu Leu Val Gln Arg His Pro Asn Thr His Asp Arg Leu Pro Pro 
            20                  25                  30          


Gly Pro Arg Pro Leu Pro Leu Leu Gly Asn Leu Leu Gln Met Asp Arg 
        35                  40                  45              


Arg Gly Leu Leu Lys Ser Phe Leu Arg Phe Arg Glu Lys Tyr Gly Asp 
    50                  55                  60                  


Val Phe Thr Val His Leu Gly Pro Arg Pro Val Val Met Leu Cys Gly 
65                  70                  75                  80  


Val Glu Ala Ile Arg Glu Ala Leu Val Asp Lys Ala Glu Ala Phe Ser 
                85                  90                  95      


Gly Arg Gly Lys Ile Ala Met Val Asp Pro Phe Phe Arg Gly Tyr Gly 
            100                 105                 110         


Val Ile Phe Ala Asn Gly Asn Arg Trp Lys Val Leu Arg Arg Phe Ser 
        115                 120                 125             


Val Thr Thr Met Arg Asp Phe Gly Met Gly Lys Arg Ser Val Glu Glu 
    130                 135                 140                 


Arg Ile Gln Glu Glu Ala Gln Cys Leu Ile Glu Glu Leu Arg Lys Ser 
145                 150                 155                 160 


Lys Gly Ala Leu Met Asp Pro Thr Phe Leu Phe Gln Ser Ile Thr Ala 
                165                 170                 175     


Asn Ile Ile Cys Ser Ile Val Phe Gly Lys Arg Phe His Tyr Gln Asp 
            180                 185                 190         


Gln Glu Phe Leu Lys Met Leu Asn Leu Phe Tyr Gln Thr Phe Ser Leu 
        195                 200                 205             


Ile Ser Ser Val Phe Gly Gln Leu Phe Glu Leu Phe Ser Gly Phe Leu 
    210                 215                 220                 


Lys Tyr Phe Pro Gly Ala His Arg Gln Val Tyr Lys Asn Leu Gln Glu 
225                 230                 235                 240 


Ile Asn Ala Tyr Ile Gly His Ser Val Glu Lys His Arg Glu Thr Leu 
                245                 250                 255     


Asp Pro Ser Ala Pro Lys Asp Leu Ile Asp Thr Tyr Leu Leu His Met 
            260                 265                 270         


Glu Lys Glu Lys Ser Asn Ala His Ser Glu Phe Ser His Gln Asn Leu 
        275                 280                 285             


Asn Leu Asn Thr Leu Ser Leu Phe Phe Ala Gly Thr Glu Thr Thr Ser 
    290                 295                 300                 


Thr Thr Leu Arg Tyr Gly Phe Leu Leu Met Leu Lys Tyr Pro His Val 
305                 310                 315                 320 


Ala Glu Arg Val Tyr Arg Glu Ile Glu Gln Val Ile Gly Pro His Arg 
                325                 330                 335     


Pro Pro Glu Leu His Asp Arg Ala Lys Met Pro Tyr Thr Glu Ala Val 
            340                 345                 350         


Ile Tyr Glu Ile Gln Arg Phe Ser Asp Leu Leu Pro Met Gly Val Pro 
        355                 360                 365             


His Ile Val Thr Gln His Thr Ser Phe Arg Gly Tyr Ile Ile Pro Lys 
    370                 375                 380                 


Asp Thr Glu Val Phe Leu Ile Leu Ser Thr Ala Leu His Asp Pro His 
385                 390                 395                 400 


Tyr Phe Glu Lys Pro Asp Ala Phe Asn Pro Asp His Phe Leu Asp Ala 
                405                 410                 415     


Asn Gly Ala Leu Lys Lys Thr Glu Ala Phe Ile Pro Phe Ser Leu Gly 
            420                 425                 430         


Lys Arg Ile Cys Leu Gly Glu Gly Ile Ala Arg Ala Glu Leu Phe Leu 
        435                 440                 445             


Phe Phe Thr Thr Ile Leu Gln Asn Phe Ser Met Ala Ser Pro Val Ala 
    450                 455                 460                 


Pro Glu Asp Ile Asp Leu Thr Pro Gln Glu Cys Gly Val Gly Lys Ile 
465                 470                 475                 480 


Pro Pro Thr Tyr Gln Ile Arg Phe Leu Pro Arg 
                485                 490     


<210>  3864
<211>  255
<212>  PRT
<213>  Homo Sapiens

<400>  3864

Met Leu Cys Gly Val Glu Ala Ile Arg Glu Ala Leu Val Asp Lys Ala 
1               5                   10                  15      


Glu Ala Phe Ser Gly Arg Gly Lys Ile Ala Met Val Asp Pro Phe Phe 
            20                  25                  30          


Arg Gly Tyr Gly Val Ile Phe Ala Asn Gly Asn Arg Trp Lys Val Leu 
        35                  40                  45              


Arg Arg Phe Ser Val Thr Thr Met Arg Asp Phe Gly Met Gly Lys Arg 
    50                  55                  60                  


Ser Val Glu Glu Arg Ile Gln Glu Glu Ala Gln Cys Leu Ile Glu Glu 
65                  70                  75                  80  


Leu Arg Lys Ser Lys Glu Arg Val Tyr Arg Glu Ile Glu Gln Val Ile 
                85                  90                  95      


Gly Pro His Arg Pro Pro Glu Leu His Asp Arg Ala Lys Met Pro Tyr 
            100                 105                 110         


Thr Glu Ala Val Ile Tyr Glu Ile Gln Arg Phe Ser Asp Leu Leu Pro 
        115                 120                 125             


Met Gly Val Pro His Ile Val Thr Gln His Thr Ser Phe Arg Gly Tyr 
    130                 135                 140                 


Ile Ile Pro Lys Asp Thr Glu Val Phe Leu Ile Leu Ser Thr Ala Leu 
145                 150                 155                 160 


His Asp Pro His Tyr Phe Glu Lys Pro Asp Ala Phe Asn Pro Asp His 
                165                 170                 175     


Phe Leu Asp Ala Asn Gly Ala Leu Lys Lys Thr Glu Ala Phe Ile Pro 
            180                 185                 190         


Phe Ser Leu Gly Lys Arg Ile Cys Leu Gly Glu Gly Ile Ala Arg Ala 
        195                 200                 205             


Glu Leu Phe Leu Phe Phe Thr Thr Ile Leu Gln Asn Phe Ser Met Ala 
    210                 215                 220                 


Ser Pro Val Ala Pro Glu Asp Ile Asp Leu Thr Pro Gln Glu Cys Gly 
225                 230                 235                 240 


Val Gly Lys Ile Pro Pro Thr Tyr Gln Ile Arg Phe Leu Pro Arg 
                245                 250                 255 


<210>  3865
<211>  194
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3865

Xaa Pro Arg Pro Leu Pro Leu Leu Gly Asn Leu Leu Gln Met Asp Arg 
1               5                   10                  15      


Arg Gly Leu Leu Lys Ser Phe Leu Arg Phe Arg Glu Lys Tyr Gly Asp 
            20                  25                  30          


Val Phe Thr Val His Leu Gly Pro Arg Pro Val Val Met Leu Cys Gly 
        35                  40                  45              


Val Glu Ala Ile Arg Glu Ala Leu Val Asp Lys Ala Glu Ala Phe Ser 
    50                  55                  60                  


Gly Arg Gly Lys Ile Ala Met Val Asp Pro Phe Phe Arg Gly Tyr Gly 
65                  70                  75                  80  


Val Ile Phe Ala Asn Gly Asn Arg Trp Lys Val Leu Arg Arg Phe Ser 
                85                  90                  95      


Val Thr Thr Met Arg Asp Phe Gly Met Gly Lys Arg Ser Val Glu Glu 
            100                 105                 110         


Arg Ile Gln Glu Glu Ala Gln Cys Leu Ile Glu Glu Leu Arg Lys Ser 
        115                 120                 125             


Lys Gly Ala Leu Met Asp Pro Thr Phe Leu Phe Gln Ser Ile Thr Ala 
    130                 135                 140                 


Asn Ile Ile Cys Ser Ile Val Phe Gly Lys Arg Phe His Tyr Gln Asp 
145                 150                 155                 160 


Gln Glu Phe Leu Lys Met Leu Asn Leu Phe Tyr Gln Thr Phe Ser Leu 
                165                 170                 175     


Ile Ser Ser Val Phe Gly Gln Thr Glu Ser Arg Cys Phe Ile Pro Ala 
            180                 185                 190         


Gly Val 
        


<210>  3866
<211>  431
<212>  PRT
<213>  Homo Sapiens

<400>  3866

Met Asp Pro Ala Val Ala Leu Val Leu Cys Leu Ser Cys Leu Phe Leu 
1               5                   10                  15      


Leu Ser Leu Trp Arg Gln Ser Ser Gly Arg Gly Arg Leu Pro Ser Gly 
            20                  25                  30          


Pro Thr Pro Leu Pro Ile Ile Gly Asn Ile Leu Gln Leu Asp Val Lys 
        35                  40                  45              


Asp Met Ser Lys Ser Leu Thr Asn Phe Ser Lys Val Tyr Gly Pro Val 
    50                  55                  60                  


Phe Thr Val Tyr Phe Gly Leu Lys Pro Ile Val Val Leu His Gly Tyr 
65                  70                  75                  80  


Glu Ala Val Lys Glu Ala Leu Ile Asp His Gly Glu Glu Phe Ser Gly 
                85                  90                  95      


Arg Gly Ser Phe Pro Val Ala Glu Lys Val Asn Lys Gly Leu Gly Ile 
            100                 105                 110         


Leu Phe Ser Asn Gly Lys Arg Trp Lys Glu Ile Arg Arg Phe Cys Leu 
        115                 120                 125             


Met Thr Leu Arg Asn Phe Gly Met Gly Lys Arg Ser Ile Glu Asp Arg 
    130                 135                 140                 


Val Gln Glu Glu Ala Arg Cys Leu Val Glu Glu Leu Arg Lys Thr Asn 
145                 150                 155                 160 


Ala Ser Pro Cys Asp Pro Thr Phe Ile Leu Gly Cys Ala Pro Cys Asn 
                165                 170                 175     


Val Ile Cys Ser Val Ile Phe His Asp Arg Phe Asp Tyr Lys Asp Gln 
            180                 185                 190         


Arg Phe Leu Asn Leu Met Glu Lys Phe Asn Glu Asn Leu Arg Ile Leu 
        195                 200                 205             


Ser Ser Pro Trp Ile Gln Glu Lys His Asn Gln Gln Ser Glu Phe Thr 
    210                 215                 220                 


Val Glu Ser Leu Ile Ala Thr Val Thr Asp Met Phe Gly Ala Gly Thr 
225                 230                 235                 240 


Glu Thr Thr Ser Thr Thr Leu Arg Tyr Gly Leu Leu Leu Leu Leu Lys 
                245                 250                 255     


Tyr Pro Glu Val Thr Ala Lys Val Gln Glu Glu Ile Glu Cys Val Val 
            260                 265                 270         


Gly Arg Asn Arg Ser Pro Cys Met Gln Asp Arg Ser His Met Pro Tyr 
        275                 280                 285             


Thr Asp Ala Val Val His Glu Ile Gln Arg Tyr Ile Asp Leu Leu Pro 
    290                 295                 300                 


Thr Asn Leu Pro His Ala Val Thr Cys Asp Val Lys Phe Lys Asn Tyr 
305                 310                 315                 320 


Leu Ile Pro Lys Gly Thr Thr Ile Ile Thr Ser Leu Thr Ser Val Leu 
                325                 330                 335     


His Asn Asp Lys Glu Phe Pro Asn Pro Glu Met Phe Asp Pro Gly His 
            340                 345                 350         


Phe Leu Asp Lys Ser Gly Asn Phe Lys Lys Ser Asp Tyr Phe Met Pro 
        355                 360                 365             


Phe Ser Ala Gly Lys Arg Met Cys Met Gly Glu Gly Leu Ala Arg Met 
    370                 375                 380                 


Glu Leu Phe Leu Phe Leu Thr Thr Ile Leu Gln Asn Phe Asn Leu Lys 
385                 390                 395                 400 


Ser Gln Val Asp Pro Lys Asp Ile Asp Ile Thr Pro Ile Ala Asn Ala 
                405                 410                 415     


Phe Gly Arg Val Pro Pro Leu Tyr Gln Leu Cys Phe Ile Pro Val 
            420                 425                 430     


<210>  3867
<211>  490
<212>  PRT
<213>  Homo Sapiens

<400>  3867

Met Asp Pro Ala Val Ala Leu Val Leu Cys Leu Ser Cys Leu Phe Leu 
1               5                   10                  15      


Leu Ser Leu Trp Arg Gln Ser Ser Gly Arg Gly Arg Leu Pro Ser Gly 
            20                  25                  30          


Pro Thr Pro Leu Pro Ile Ile Gly Asn Ile Leu Gln Leu Asp Val Lys 
        35                  40                  45              


Asp Met Ser Lys Ser Leu Thr Asn Phe Ser Lys Val Tyr Gly Pro Val 
    50                  55                  60                  


Phe Thr Val Tyr Phe Gly Leu Lys Pro Ile Val Val Leu His Gly Tyr 
65                  70                  75                  80  


Glu Ala Val Lys Glu Ala Leu Ile Asp His Gly Glu Glu Phe Ser Gly 
                85                  90                  95      


Arg Gly Ser Phe Pro Val Ala Glu Lys Val Asn Lys Gly Leu Gly Ile 
            100                 105                 110         


Leu Phe Ser Asn Gly Lys Arg Trp Lys Glu Ile Arg Arg Phe Cys Leu 
        115                 120                 125             


Met Thr Leu Arg Asn Phe Gly Met Gly Lys Arg Ser Ile Glu Asp Arg 
    130                 135                 140                 


Val Gln Glu Glu Ala Arg Cys Leu Val Glu Glu Leu Arg Lys Thr Asn 
145                 150                 155                 160 


Ala Ser Pro Cys Asp Pro Thr Phe Ile Leu Gly Cys Ala Pro Cys Asn 
                165                 170                 175     


Val Ile Cys Ser Val Ile Phe His Asp Arg Phe Asp Tyr Lys Asp Gln 
            180                 185                 190         


Arg Phe Leu Asn Leu Met Glu Lys Phe Asn Glu Asn Leu Arg Ile Leu 
        195                 200                 205             


Ser Ser Pro Trp Ile Gln Val Cys Asn Asn Phe Pro Ala Leu Ile Asp 
    210                 215                 220                 


Tyr Leu Pro Gly Ser His Asn Lys Ile Ala Glu Asn Phe Ala Tyr Ile 
225                 230                 235                 240 


Lys Ser Tyr Val Leu Glu Arg Ile Lys Glu His Gln Glu Ser Leu Asp 
                245                 250                 255     


Met Asn Ser Ala Arg Asp Phe Ile Asp Cys Phe Leu Ile Lys Met Glu 
            260                 265                 270         


Gln Glu Lys His Asn Gln Gln Ser Glu Phe Thr Val Glu Ser Leu Ile 
        275                 280                 285             


Ala Thr Val Thr Asp Met Phe Gly Ala Gly Thr Glu Thr Thr Ser Thr 
    290                 295                 300                 


Thr Leu Arg Tyr Gly Leu Leu Leu Leu Leu Lys Tyr Pro Glu Val Thr 
305                 310                 315                 320 


Ala Lys Val Gln Glu Glu Ile Glu Cys Val Val Gly Arg Asn Arg Ser 
                325                 330                 335     


Pro Cys Met Gln Asp Arg Ser His Met Pro Tyr Thr Asp Ala Val Val 
            340                 345                 350         


His Glu Ile Gln Arg Tyr Ile Asp Leu Leu Pro Thr Asn Leu Pro His 
        355                 360                 365             


Ala Val Thr Cys Asp Val Lys Phe Lys Asn Tyr Leu Ile Pro Lys Gly 
    370                 375                 380                 


Thr Thr Ile Ile Thr Ser Leu Thr Ser Val Leu His Asn Asp Lys Glu 
385                 390                 395                 400 


Phe Pro Asn Pro Glu Met Phe Asp Pro Gly His Phe Leu Asp Lys Ser 
                405                 410                 415     


Gly Asn Phe Lys Lys Ser Asp Tyr Phe Met Pro Phe Ser Ala Gly Lys 
            420                 425                 430         


Arg Met Cys Met Gly Glu Gly Leu Ala Arg Met Glu Leu Phe Leu Phe 
        435                 440                 445             


Leu Thr Thr Ile Leu Gln Asn Phe Asn Leu Lys Ser Gln Val Asp Pro 
    450                 455                 460                 


Lys Asp Ile Asp Ile Thr Pro Ile Ala Asn Ala Phe Gly Arg Val Pro 
465                 470                 475                 480 


Pro Leu Tyr Gln Leu Cys Phe Ile Pro Val 
                485                 490 


<210>  3868
<211>  490
<212>  PRT
<213>  Homo Sapiens

<400>  3868

Met Asp Pro Phe Val Val Leu Val Leu Cys Leu Ser Cys Leu Leu Leu 
1               5                   10                  15      


Leu Ser Ile Trp Arg Gln Ser Ser Gly Arg Gly Lys Leu Pro Pro Gly 
            20                  25                  30          


Pro Thr Pro Leu Pro Val Ile Gly Asn Ile Leu Gln Ile Asp Ile Lys 
        35                  40                  45              


Asp Val Ser Lys Ser Leu Thr Asn Leu Ser Lys Ile Tyr Gly Pro Val 
    50                  55                  60                  


Phe Thr Leu Tyr Phe Gly Leu Glu Arg Met Val Val Leu His Gly Tyr 
65                  70                  75                  80  


Glu Val Val Lys Glu Ala Leu Ile Asp Leu Gly Glu Glu Phe Ser Gly 
                85                  90                  95      


Arg Gly His Phe Pro Leu Ala Glu Arg Ala Asn Arg Gly Phe Gly Ile 
            100                 105                 110         


Val Phe Ser Asn Gly Lys Arg Trp Lys Glu Ile Arg Arg Phe Ser Leu 
        115                 120                 125             


Met Thr Leu Arg Asn Phe Gly Met Gly Lys Arg Ser Ile Glu Asp Arg 
    130                 135                 140                 


Val Gln Glu Glu Ala Arg Cys Leu Val Glu Glu Leu Arg Lys Thr Lys 
145                 150                 155                 160 


Ala Ser Pro Cys Asp Pro Thr Phe Ile Leu Gly Cys Ala Pro Cys Asn 
                165                 170                 175     


Val Ile Cys Ser Ile Ile Phe Gln Lys Arg Phe Asp Tyr Lys Asp Gln 
            180                 185                 190         


Gln Phe Leu Asn Leu Met Glu Lys Leu Asn Glu Asn Ile Arg Ile Val 
        195                 200                 205             


Ser Thr Pro Trp Ile Gln Ile Cys Asn Asn Phe Pro Thr Ile Ile Asp 
    210                 215                 220                 


Tyr Phe Pro Gly Thr His Asn Lys Leu Leu Lys Asn Leu Ala Phe Met 
225                 230                 235                 240 


Glu Ser Asp Ile Leu Glu Lys Val Lys Glu His Gln Glu Ser Met Asp 
                245                 250                 255     


Ile Asn Asn Pro Arg Asp Phe Ile Asp Cys Phe Leu Ile Lys Met Glu 
            260                 265                 270         


Lys Glu Lys Gln Asn Gln Gln Ser Glu Phe Thr Ile Glu Asn Leu Val 
        275                 280                 285             


Ile Thr Ala Ala Asp Leu Leu Gly Ala Gly Thr Glu Thr Thr Ser Thr 
    290                 295                 300                 


Thr Leu Arg Tyr Ala Leu Leu Leu Leu Leu Lys His Pro Glu Val Thr 
305                 310                 315                 320 


Ala Lys Val Gln Glu Glu Ile Glu Arg Val Ile Gly Arg Asn Arg Ser 
                325                 330                 335     


Pro Cys Met Gln Asp Arg Gly His Met Pro Tyr Thr Asp Ala Val Val 
            340                 345                 350         


His Glu Val Gln Arg Tyr Ile Asp Leu Ile Pro Thr Ser Leu Pro His 
        355                 360                 365             


Ala Val Thr Cys Asp Val Lys Phe Arg Asn Tyr Leu Ile Pro Lys Gly 
    370                 375                 380                 


Thr Thr Ile Leu Thr Ser Leu Thr Ser Val Leu His Asp Asn Lys Glu 
385                 390                 395                 400 


Phe Pro Asn Pro Glu Met Phe Asp Pro Arg His Phe Leu Asp Glu Gly 
                405                 410                 415     


Gly Asn Phe Lys Lys Ser Asn Tyr Phe Met Pro Phe Ser Ala Gly Lys 
            420                 425                 430         


Arg Ile Cys Val Gly Glu Gly Leu Ala Arg Met Glu Leu Phe Leu Phe 
        435                 440                 445             


Leu Thr Phe Ile Leu Gln Asn Phe Asn Leu Lys Ser Leu Ile Asp Pro 
    450                 455                 460                 


Lys Asp Leu Asp Thr Thr Pro Val Val Asn Gly Phe Ala Ser Val Pro 
465                 470                 475                 480 


Pro Phe Tyr Gln Leu Cys Phe Ile Pro Val 
                485                 490 


<210>  3869
<211>  162
<212>  PRT
<213>  Homo Sapiens

<400>  3869

Met Asp Pro Phe Val Val Leu Val Leu Cys Leu Ser Cys Leu Leu Leu 
1               5                   10                  15      


Leu Ser Ile Trp Arg Gln Ser Ser Gly Arg Gly Lys Leu Pro Pro Gly 
            20                  25                  30          


Pro Thr Pro Leu Pro Val Ile Gly Asn Ile Leu Gln Ile Asp Ile Lys 
        35                  40                  45              


Asp Val Ser Lys Ser Leu Thr Asn Leu Ser Lys Ile Tyr Gly Pro Val 
    50                  55                  60                  


Phe Thr Leu Tyr Phe Gly Leu Glu Arg Met Val Val Leu His Gly Tyr 
65                  70                  75                  80  


Glu Val Val Lys Glu Ala Leu Ile Asp Leu Gly Glu Glu Phe Ser Gly 
                85                  90                  95      


Arg Gly His Phe Pro Leu Ala Glu Arg Ala Asn Arg Gly Phe Gly Ile 
            100                 105                 110         


Val Phe Ser Asn Gly Lys Arg Trp Lys Glu Ile Arg Arg Phe Ser Leu 
        115                 120                 125             


Met Thr Leu Arg Asn Phe Gly Met Gly Lys Arg Ser Ile Glu Asp Arg 
    130                 135                 140                 


Val Gln Glu Glu Ala Arg Cys Leu Val Glu Glu Leu Arg Lys Thr Lys 
145                 150                 155                 160 


Gly Gly 
        


<210>  3870
<211>  307
<212>  PRT
<213>  Homo Sapiens

<400>  3870

Met Ala Ala Lys Cys Cys Ser Thr Phe Phe Leu Gly Cys Glu Phe Ser 
1               5                   10                  15      


Gln Phe Leu Pro Leu Phe Leu Leu Gly Ile Ile Ser Ser Asn Gly Lys 
            20                  25                  30          


Arg Trp Lys Glu Ile Arg Arg Phe Ser Leu Thr Thr Leu Arg Asn Phe 
        35                  40                  45              


Gly Met Gly Lys Arg Ser Ile Glu Asp Arg Val Gln Glu Glu Ala His 
    50                  55                  60                  


Cys Leu Val Glu Glu Leu Arg Lys Thr Lys Ala Ser Pro Cys Asp Pro 
65                  70                  75                  80  


Thr Phe Ile Leu Gly Cys Ala Pro Cys Asn Val Ile Cys Ser Val Val 
                85                  90                  95      


Phe Gln Lys Arg Phe Asp Tyr Lys Asp Gln Asn Phe Leu Thr Leu Met 
            100                 105                 110         


Lys Arg Phe Asn Glu Asn Phe Arg Ile Leu Asn Ser Pro Trp Ile Gln 
        115                 120                 125             


Val Cys Asn Asn Phe Pro Leu Leu Ile Asp Cys Phe Pro Gly Thr His 
    130                 135                 140                 


Asn Lys Val Leu Lys Asn Val Ala Leu Thr Arg Ser Tyr Ile Arg Glu 
145                 150                 155                 160 


Lys Val Lys Glu His Gln Ala Ser Leu Asp Val Asn Asn Pro Arg Asp 
                165                 170                 175     


Phe Ile Asp Cys Phe Leu Ile Lys Met Glu Gln Glu Lys Asp Asn Gln 
            180                 185                 190         


Lys Ser Glu Phe Asn Ile Glu Asn Leu Val Gly Thr Val Ala Asp Leu 
        195                 200                 205             


Phe Val Ala Gly Thr Glu Thr Thr Ser Thr Thr Leu Arg Tyr Gly Leu 
    210                 215                 220                 


Leu Leu Leu Leu Lys His Pro Glu Val Thr Ala Lys Val Gln Glu Glu 
225                 230                 235                 240 


Ile Asp His Val Ile Gly Arg His Arg Ser Pro Cys Met Gln Asp Arg 
                245                 250                 255     


Ser His Met Pro Tyr Thr Asp Ala Val Val His Glu Ile Gln Arg Tyr 
            260                 265                 270         


Ser Asp Leu Val Pro Thr Gly Val Pro His Ala Val Thr Thr Asp Thr 
        275                 280                 285             


Lys Phe Arg Asn Tyr Leu Ile Pro Lys Ser Phe Asp Asn Lys Ile Met 
    290                 295                 300                 


Leu Ala Ala 
305         


<210>  3871
<211>  490
<212>  PRT
<213>  Homo Sapiens

<400>  3871

Met Glu Pro Phe Val Val Leu Val Leu Cys Leu Ser Phe Met Leu Leu 
1               5                   10                  15      


Phe Ser Leu Trp Arg Gln Ser Cys Arg Arg Arg Lys Leu Pro Pro Gly 
            20                  25                  30          


Pro Thr Pro Leu Pro Ile Ile Gly Asn Met Leu Gln Ile Asp Val Lys 
        35                  40                  45              


Asp Ile Cys Lys Ser Phe Thr Asn Phe Ser Lys Val Tyr Gly Pro Val 
    50                  55                  60                  


Phe Thr Val Tyr Phe Gly Met Asn Pro Ile Val Val Phe His Gly Tyr 
65                  70                  75                  80  


Glu Ala Val Lys Glu Ala Leu Ile Asp Asn Gly Glu Glu Phe Ser Gly 
                85                  90                  95      


Arg Gly Asn Ser Pro Ile Ser Gln Arg Ile Thr Lys Gly Leu Gly Ile 
            100                 105                 110         


Ile Ser Ser Asn Gly Lys Arg Trp Lys Glu Ile Arg Arg Phe Ser Leu 
        115                 120                 125             


Thr Thr Leu Arg Asn Phe Gly Met Gly Lys Arg Ser Ile Glu Asp Arg 
    130                 135                 140                 


Val Gln Glu Glu Ala His Cys Leu Val Glu Glu Leu Arg Lys Thr Lys 
145                 150                 155                 160 


Ala Ser Pro Cys Asp Pro Thr Phe Ile Leu Gly Cys Ala Pro Cys Asn 
                165                 170                 175     


Val Ile Cys Ser Val Val Phe Gln Lys Arg Phe Asp Tyr Lys Asp Gln 
            180                 185                 190         


Asn Phe Leu Thr Leu Met Lys Arg Phe Asn Glu Asn Phe Arg Ile Leu 
        195                 200                 205             


Asn Ser Pro Trp Ile Gln Val Cys Asn Asn Phe Pro Leu Leu Ile Asp 
    210                 215                 220                 


Cys Phe Pro Gly Thr His Asn Lys Val Leu Lys Asn Val Ala Leu Thr 
225                 230                 235                 240 


Arg Ser Tyr Ile Arg Glu Lys Val Lys Glu His Gln Ala Ser Leu Asp 
                245                 250                 255     


Val Asn Asn Pro Arg Asp Phe Ile Asp Cys Phe Leu Ile Lys Met Glu 
            260                 265                 270         


Gln Glu Lys Asp Asn Gln Lys Ser Glu Phe Asn Ile Glu Asn Leu Val 
        275                 280                 285             


Gly Thr Val Ala Asp Leu Phe Val Ala Gly Thr Glu Thr Thr Ser Thr 
    290                 295                 300                 


Thr Leu Arg Tyr Gly Leu Leu Leu Leu Leu Lys His Pro Glu Val Thr 
305                 310                 315                 320 


Ala Lys Val Gln Glu Glu Ile Asp His Val Ile Gly Arg His Arg Ser 
                325                 330                 335     


Pro Cys Met Gln Asp Arg Ser His Met Pro Tyr Thr Asp Ala Val Val 
            340                 345                 350         


His Glu Ile Gln Arg Tyr Ser Asp Leu Val Pro Thr Gly Val Pro His 
        355                 360                 365             


Ala Val Thr Thr Asp Thr Lys Phe Arg Asn Tyr Leu Ile Pro Lys Gly 
    370                 375                 380                 


Thr Thr Ile Met Ala Leu Leu Thr Ser Val Leu His Asp Asp Lys Glu 
385                 390                 395                 400 


Phe Pro Asn Pro Asn Ile Phe Asp Pro Gly His Phe Leu Asp Lys Asn 
                405                 410                 415     


Gly Asn Phe Lys Lys Ser Asp Tyr Phe Met Pro Phe Ser Ala Gly Lys 
            420                 425                 430         


Arg Ile Cys Ala Gly Glu Gly Leu Ala Arg Met Glu Leu Phe Leu Phe 
        435                 440                 445             


Leu Thr Thr Ile Leu Gln Asn Phe Asn Leu Lys Ser Val Asp Asp Leu 
    450                 455                 460                 


Lys Asn Leu Asn Thr Thr Ala Val Thr Lys Gly Ile Val Ser Leu Pro 
465                 470                 475                 480 


Pro Ser Tyr Gln Ile Cys Phe Ile Pro Val 
                485                 490 


<210>  3872
<211>  393
<212>  PRT
<213>  Homo Sapiens

<400>  3872

Met Glu Pro Phe Val Val Leu Val Leu Cys Leu Ser Phe Met Leu Leu 
1               5                   10                  15      


Phe Ser Leu Trp Arg Gln Ser Cys Arg Arg Arg Lys Leu Pro Pro Gly 
            20                  25                  30          


Pro Thr Pro Leu Pro Ile Ile Gly Asn Met Leu Gln Ile Asp Val Lys 
        35                  40                  45              


Asp Ile Cys Lys Ser Phe Thr Asn Phe Ser Lys Val Tyr Gly Pro Val 
    50                  55                  60                  


Phe Thr Val Tyr Phe Gly Met Asn Pro Ile Val Val Phe His Gly Tyr 
65                  70                  75                  80  


Glu Ala Val Lys Glu Ala Leu Ile Asp Asn Gly Glu Glu Phe Ser Gly 
                85                  90                  95      


Arg Gly Asn Ser Pro Ile Ser Gln Arg Ile Thr Lys Gly Leu Gly Ile 
            100                 105                 110         


Ile Ser Ser Asn Gly Lys Arg Trp Lys Glu Ile Arg Arg Phe Ser Leu 
        115                 120                 125             


Thr Thr Leu Arg Asn Phe Gly Met Gly Lys Arg Ser Ile Glu Asp Arg 
    130                 135                 140                 


Val Gln Glu Glu Ala His Cys Leu Val Glu Glu Leu Arg Lys Thr Lys 
145                 150                 155                 160 


Ala Ser Pro Cys Asp Pro Thr Phe Ile Leu Gly Cys Ala Pro Cys Asn 
                165                 170                 175     


Val Ile Cys Ser Val Val Phe Gln Lys Arg Phe Asp Tyr Lys Asp Gln 
            180                 185                 190         


Asn Phe Leu Thr Leu Met Lys Arg Phe Asn Glu Asn Phe Arg Ile Leu 
        195                 200                 205             


Asn Ser Pro Trp Ile Gln Val Cys Asn Asn Phe Pro Leu Leu Ile Asp 
    210                 215                 220                 


Cys Phe Pro Gly Thr His Asn Lys Val Leu Lys Asn Val Ala Leu Thr 
225                 230                 235                 240 


Arg Ser Tyr Ile Arg Glu Lys Val Lys Glu His Gln Ala Ser Leu Asp 
                245                 250                 255     


Val Asn Asn Pro Arg Asp Phe Ile Asp Cys Phe Leu Ile Lys Met Glu 
            260                 265                 270         


Gln Glu Lys Asp Asn Gln Lys Ser Glu Phe Asn Ile Glu Asn Leu Val 
        275                 280                 285             


Gly Thr Val Ala Asp Leu Phe Val Ala Gly Thr Glu Thr Thr Ser Thr 
    290                 295                 300                 


Thr Leu Arg Tyr Gly Leu Leu Leu Leu Leu Lys His Pro Glu Val Thr 
305                 310                 315                 320 


Ala Lys Val Gln Glu Glu Ile Asp His Val Ile Gly Arg His Arg Ser 
                325                 330                 335     


Pro Cys Met Gln Asp Arg Ser His Met Pro Tyr Thr Asp Ala Val Val 
            340                 345                 350         


His Glu Ile Gln Arg Tyr Ser Asp Leu Val Pro Thr Gly Val Pro His 
        355                 360                 365             


Ala Val Thr Thr Asp Thr Lys Phe Arg Asn Tyr Leu Ile Pro Lys Ser 
    370                 375                 380                 


Phe Asp Asn Lys Ile Met Leu Ala Ala 
385                 390             


<210>  3873
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  3873

Met Glu Pro Phe Val Val Leu Val Leu Cys Leu Ser Phe Met Leu Leu 
1               5                   10                  15      


Phe Ser Leu Trp Arg Gln Ser Cys Arg Arg Arg Lys Leu Pro Pro Gly 
            20                  25                  30          


Pro Thr Pro Leu Pro Ile Ile Gly Asn Met Leu Gln Ile Asp Val Lys 
        35                  40                  45              


Asp Ile Cys Lys Ser Phe Thr Asn Val Ser Leu Pro Tyr Val Pro Pro 
    50                  55                  60                  


Ala Asn Cys Lys Gly Asn His Phe Gln Gln Trp Lys Glu Met Glu Gly 
65                  70                  75                  80  


Asp Pro Ala Phe Leu Pro His Asn Leu Ala Glu Phe Trp Asp Gly Glu 
                85                  90                  95      


Glu Glu His 
            


<210>  3874
<211>  83
<212>  PRT
<213>  Homo Sapiens

<400>  3874

Met Glu Pro Phe Val Val Leu Val Leu Cys Leu Ser Phe Met Leu Leu 
1               5                   10                  15      


Phe Ser Leu Trp Arg Gln Ser Cys Arg Arg Arg Lys Leu Pro Pro Gly 
            20                  25                  30          


Pro Thr Pro Leu Pro Ile Ile Gly Asn Met Leu Gln Ile Asp Val Lys 
        35                  40                  45              


Asp Ile Cys Lys Ser Phe Thr Asn Val Ser Leu Pro Tyr Val Pro Pro 
    50                  55                  60                  


Ala Asn Cys Lys Gly Ser Gln Lys Ser Met Val Leu Cys Ser Pro Cys 
65                  70                  75                  80  


Ile Leu Ala 
            


<210>  3875
<211>  388
<212>  PRT
<213>  Homo Sapiens

<400>  3875

Met Phe Leu Gln Pro Ile Ala Lys Gly Ile Ile Ser Ser Asn Gly Lys 
1               5                   10                  15      


Arg Trp Lys Glu Ile Arg Arg Phe Ser Leu Thr Thr Leu Arg Asn Phe 
            20                  25                  30          


Gly Met Gly Lys Arg Ser Ile Glu Asp Arg Val Gln Glu Glu Ala His 
        35                  40                  45              


Cys Leu Val Glu Glu Leu Arg Lys Thr Lys Ala Ser Pro Cys Asp Pro 
    50                  55                  60                  


Thr Phe Ile Leu Gly Cys Ala Pro Cys Asn Val Ile Cys Ser Val Val 
65                  70                  75                  80  


Phe Gln Lys Arg Phe Asp Tyr Lys Asp Gln Asn Phe Leu Thr Leu Met 
                85                  90                  95      


Lys Arg Phe Asn Glu Asn Phe Arg Ile Leu Asn Ser Pro Trp Ile Gln 
            100                 105                 110         


Val Cys Asn Asn Phe Pro Leu Leu Ile Asp Cys Phe Pro Gly Thr His 
        115                 120                 125             


Asn Lys Val Leu Lys Asn Val Ala Leu Thr Arg Ser Tyr Ile Arg Glu 
    130                 135                 140                 


Lys Val Lys Glu His Gln Ala Ser Leu Asp Val Asn Asn Pro Arg Asp 
145                 150                 155                 160 


Phe Ile Asp Cys Phe Leu Ile Lys Met Glu Gln Glu Lys Asp Asn Gln 
                165                 170                 175     


Lys Ser Glu Phe Asn Ile Glu Asn Leu Val Gly Thr Val Ala Asp Leu 
            180                 185                 190         


Phe Val Ala Gly Thr Glu Thr Thr Ser Thr Thr Leu Arg Tyr Gly Leu 
        195                 200                 205             


Leu Leu Leu Leu Lys His Pro Glu Val Thr Ala Lys Val Gln Glu Glu 
    210                 215                 220                 


Ile Asp His Val Ile Gly Arg His Arg Ser Pro Cys Met Gln Asp Arg 
225                 230                 235                 240 


Ser His Met Pro Tyr Thr Asp Ala Val Val His Glu Ile Gln Arg Tyr 
                245                 250                 255     


Ser Asp Leu Val Pro Thr Gly Val Pro His Ala Val Thr Thr Asp Thr 
            260                 265                 270         


Lys Phe Arg Asn Tyr Leu Ile Pro Lys Gly Thr Thr Ile Met Ala Leu 
        275                 280                 285             


Leu Thr Ser Val Leu His Asp Asp Lys Glu Phe Pro Asn Pro Asn Ile 
    290                 295                 300                 


Phe Asp Pro Gly His Phe Leu Asp Lys Asn Gly Asn Phe Lys Lys Ser 
305                 310                 315                 320 


Asp Tyr Phe Met Pro Phe Ser Ala Gly Lys Arg Ile Cys Ala Gly Glu 
                325                 330                 335     


Gly Leu Ala Arg Met Glu Leu Phe Leu Phe Leu Thr Thr Ile Leu Gln 
            340                 345                 350         


Asn Phe Asn Leu Lys Ser Val Asp Asp Leu Lys Asn Leu Asn Thr Thr 
        355                 360                 365             


Ala Val Thr Lys Gly Ile Val Ser Leu Pro Pro Ser Tyr Gln Ile Cys 
    370                 375                 380                 


Phe Ile Pro Val 
385             


<210>  3876
<211>  420
<212>  PRT
<213>  Homo Sapiens

<400>  3876

Met Asn Pro Ile Val Val Phe His Gly Tyr Glu Ala Val Lys Glu Ala 
1               5                   10                  15      


Leu Ile Asp Asn Gly Glu Glu Phe Ser Gly Arg Gly Asn Ser Pro Ile 
            20                  25                  30          


Ser Gln Arg Ile Thr Lys Gly Leu Gly Ile Ile Ser Ser Asn Gly Lys 
        35                  40                  45              


Arg Trp Lys Glu Ile Arg Arg Phe Ser Leu Thr Thr Leu Arg Asn Phe 
    50                  55                  60                  


Gly Met Gly Lys Arg Ser Ile Glu Asp Arg Val Gln Glu Glu Ala His 
65                  70                  75                  80  


Cys Leu Val Glu Glu Leu Arg Lys Thr Lys Ala Ser Pro Cys Asp Pro 
                85                  90                  95      


Thr Phe Ile Leu Gly Cys Ala Pro Cys Asn Val Ile Cys Ser Val Val 
            100                 105                 110         


Phe Gln Lys Arg Phe Asp Tyr Lys Asp Gln Asn Phe Leu Thr Leu Met 
        115                 120                 125             


Lys Arg Phe Asn Glu Asn Phe Arg Ile Leu Asn Ser Pro Trp Ile Gln 
    130                 135                 140                 


Val Cys Asn Asn Phe Pro Leu Leu Ile Asp Cys Phe Pro Gly Thr His 
145                 150                 155                 160 


Asn Lys Val Leu Lys Asn Val Ala Leu Thr Arg Ser Tyr Ile Arg Glu 
                165                 170                 175     


Lys Val Lys Glu His Gln Ala Ser Leu Asp Val Asn Asn Pro Arg Asp 
            180                 185                 190         


Phe Ile Asp Cys Phe Leu Ile Lys Met Glu Gln Glu Lys Asp Asn Gln 
        195                 200                 205             


Lys Ser Glu Phe Asn Ile Glu Asn Leu Val Gly Thr Val Ala Asp Leu 
    210                 215                 220                 


Phe Val Ala Gly Thr Glu Thr Thr Ser Thr Thr Leu Arg Tyr Gly Leu 
225                 230                 235                 240 


Leu Leu Leu Leu Lys His Pro Glu Val Thr Ala Lys Val Gln Glu Glu 
                245                 250                 255     


Ile Asp His Val Ile Gly Arg His Arg Ser Pro Cys Met Gln Asp Arg 
            260                 265                 270         


Ser His Met Pro Tyr Thr Asp Ala Val Val His Glu Ile Gln Arg Tyr 
        275                 280                 285             


Ser Asp Leu Val Pro Thr Gly Val Pro His Ala Val Thr Thr Asp Thr 
    290                 295                 300                 


Lys Phe Arg Asn Tyr Leu Ile Pro Lys Gly Thr Thr Ile Met Ala Leu 
305                 310                 315                 320 


Leu Thr Ser Val Leu His Asp Asp Lys Glu Phe Pro Asn Pro Asn Ile 
                325                 330                 335     


Phe Asp Pro Gly His Phe Leu Asp Lys Asn Gly Asn Phe Lys Lys Ser 
            340                 345                 350         


Asp Tyr Phe Met Pro Phe Ser Ala Gly Lys Arg Ile Cys Ala Gly Glu 
        355                 360                 365             


Gly Leu Ala Arg Met Glu Leu Phe Leu Phe Leu Thr Thr Ile Leu Gln 
    370                 375                 380                 


Asn Phe Asn Leu Lys Ser Val Asp Asp Leu Lys Asn Leu Asn Thr Thr 
385                 390                 395                 400 


Ala Val Thr Lys Gly Ile Val Ser Leu Pro Pro Ser Tyr Gln Ile Cys 
                405                 410                 415     


Phe Ile Pro Val 
            420 


<210>  3877
<211>  420
<212>  PRT
<213>  Homo Sapiens

<400>  3877

Met Asn Pro Ile Val Val Phe His Gly Tyr Glu Ala Val Lys Glu Ala 
1               5                   10                  15      


Leu Ile Asp Asn Gly Glu Glu Phe Ser Gly Arg Gly Asn Ser Pro Ile 
            20                  25                  30          


Ser Gln Arg Ile Thr Lys Gly Leu Gly Ile Ile Ser Ser Asn Gly Lys 
        35                  40                  45              


Arg Trp Lys Glu Ile Arg Arg Phe Ser Leu Thr Thr Leu Arg Asn Phe 
    50                  55                  60                  


Gly Met Gly Lys Arg Ser Ile Glu Asp Arg Val Gln Glu Glu Ala His 
65                  70                  75                  80  


Cys Leu Val Glu Glu Leu Arg Lys Thr Lys Ala Ser Pro Cys Asp Pro 
                85                  90                  95      


Thr Phe Ile Leu Gly Cys Ala Pro Cys Asn Val Ile Cys Ser Val Val 
            100                 105                 110         


Phe Gln Lys Arg Phe Asp Tyr Lys Asp Gln Asn Phe Leu Thr Leu Met 
        115                 120                 125             


Lys Arg Phe Asn Glu Asn Phe Arg Ile Leu Asn Ser Pro Trp Ile Gln 
    130                 135                 140                 


Val Cys Asn Asn Phe Pro Leu Leu Ile Asp Cys Phe Pro Gly Thr His 
145                 150                 155                 160 


Asn Lys Val Leu Lys Asn Val Ala Leu Thr Arg Ser Tyr Ile Arg Glu 
                165                 170                 175     


Lys Val Lys Glu His Gln Ala Ser Leu Asp Val Asn Asn Pro Arg Asp 
            180                 185                 190         


Phe Ile Asp Cys Phe Leu Ile Lys Met Glu Gln Glu Lys Asp Asn Gln 
        195                 200                 205             


Lys Ser Glu Phe Asn Ile Glu Asn Leu Val Gly Thr Val Ala Asp Leu 
    210                 215                 220                 


Phe Val Ala Gly Thr Glu Thr Thr Ser Thr Thr Leu Arg Tyr Gly Leu 
225                 230                 235                 240 


Leu Leu Leu Leu Lys His Pro Glu Val Thr Ala Lys Val Gln Glu Glu 
                245                 250                 255     


Ile Asp His Val Ile Gly Arg His Arg Ser Pro Cys Met Gln Asp Arg 
            260                 265                 270         


Ser His Met Pro Tyr Thr Asp Ala Val Val His Glu Ile Gln Arg Tyr 
        275                 280                 285             


Ser Asp Leu Val Pro Thr Gly Val Pro His Ala Val Thr Thr Asp Thr 
    290                 295                 300                 


Lys Phe Arg Asn Tyr Leu Ile Pro Lys Gly Thr Thr Ile Met Ala Leu 
305                 310                 315                 320 


Leu Thr Ser Val Leu His Asp Asp Lys Glu Phe Pro Asn Pro Asn Ile 
                325                 330                 335     


Phe Asp Pro Gly His Phe Leu Asp Lys Asn Gly Asn Phe Lys Lys Ser 
            340                 345                 350         


Asp Tyr Phe Met Pro Phe Ser Ala Gly Lys Arg Ile Cys Ala Gly Glu 
        355                 360                 365             


Gly Leu Ala Arg Met Glu Leu Phe Leu Phe Leu Thr Thr Ile Leu Gln 
    370                 375                 380                 


Asn Phe Asn Leu Lys Ser Val Asp Asp Leu Lys Asn Leu Asn Thr Thr 
385                 390                 395                 400 


Ala Val Thr Lys Gly Ile Val Ser Leu Pro Pro Ser Tyr Gln Ile Cys 
                405                 410                 415     


Phe Ile Pro Val 
            420 


<210>  3878
<211>  490
<212>  PRT
<213>  Homo Sapiens

<400>  3878

Met Asp Ser Leu Val Val Leu Val Leu Cys Leu Ser Cys Leu Leu Leu 
1               5                   10                  15      


Leu Ser Leu Trp Arg Gln Ser Ser Gly Arg Gly Lys Leu Pro Pro Gly 
            20                  25                  30          


Pro Thr Pro Leu Pro Val Ile Gly Asn Ile Leu Gln Ile Gly Ile Lys 
        35                  40                  45              


Asp Ile Ser Lys Ser Leu Thr Asn Leu Ser Lys Val Tyr Gly Pro Val 
    50                  55                  60                  


Phe Thr Leu Tyr Phe Gly Leu Lys Pro Ile Val Val Leu His Gly Tyr 
65                  70                  75                  80  


Glu Ala Val Lys Glu Ala Leu Ile Asp Leu Gly Glu Glu Phe Ser Gly 
                85                  90                  95      


Arg Gly Ile Phe Pro Leu Ala Glu Arg Ala Asn Arg Gly Phe Gly Ile 
            100                 105                 110         


Val Phe Ser Asn Gly Lys Lys Trp Lys Glu Ile Arg Arg Phe Ser Leu 
        115                 120                 125             


Met Thr Leu Arg Asn Phe Gly Met Gly Lys Arg Ser Ile Glu Asp Arg 
    130                 135                 140                 


Val Gln Glu Glu Ala Arg Cys Leu Val Glu Glu Leu Arg Lys Thr Lys 
145                 150                 155                 160 


Ala Ser Pro Cys Asp Pro Thr Phe Ile Leu Gly Cys Ala Pro Cys Asn 
                165                 170                 175     


Val Ile Cys Ser Ile Ile Phe His Lys Arg Phe Asp Tyr Lys Asp Gln 
            180                 185                 190         


Gln Phe Leu Asn Leu Met Glu Lys Leu Asn Glu Asn Ile Lys Ile Leu 
        195                 200                 205             


Ser Ser Pro Trp Ile Gln Ile Cys Asn Asn Phe Ser Pro Ile Ile Asp 
    210                 215                 220                 


Tyr Phe Pro Gly Thr His Asn Lys Leu Leu Lys Asn Val Ala Phe Met 
225                 230                 235                 240 


Lys Ser Tyr Ile Leu Glu Lys Val Lys Glu His Gln Glu Ser Met Asp 
                245                 250                 255     


Met Asn Asn Pro Gln Asp Phe Ile Asp Cys Phe Leu Met Lys Met Glu 
            260                 265                 270         


Lys Glu Lys His Asn Gln Pro Ser Glu Phe Thr Ile Glu Ser Leu Glu 
        275                 280                 285             


Asn Thr Ala Val Asp Leu Phe Gly Ala Gly Thr Glu Thr Thr Ser Thr 
    290                 295                 300                 


Thr Leu Arg Tyr Ala Leu Leu Leu Leu Leu Lys His Pro Glu Val Thr 
305                 310                 315                 320 


Ala Lys Val Gln Glu Glu Ile Glu Arg Val Ile Gly Arg Asn Arg Ser 
                325                 330                 335     


Pro Cys Met Gln Asp Arg Ser His Met Pro Tyr Thr Asp Ala Val Val 
            340                 345                 350         


His Glu Val Gln Arg Tyr Ile Asp Leu Leu Pro Thr Ser Leu Pro His 
        355                 360                 365             


Ala Val Thr Cys Asp Ile Lys Phe Arg Asn Tyr Leu Ile Pro Lys Gly 
    370                 375                 380                 


Thr Thr Ile Leu Ile Ser Leu Thr Ser Val Leu His Asp Asn Lys Glu 
385                 390                 395                 400 


Phe Pro Asn Pro Glu Met Phe Asp Pro His His Phe Leu Asp Glu Gly 
                405                 410                 415     


Gly Asn Phe Lys Lys Ser Lys Tyr Phe Met Pro Phe Ser Ala Gly Lys 
            420                 425                 430         


Arg Ile Cys Val Gly Glu Ala Leu Ala Gly Met Glu Leu Phe Leu Phe 
        435                 440                 445             


Leu Thr Ser Ile Leu Gln Asn Phe Asn Leu Lys Ser Leu Val Asp Pro 
    450                 455                 460                 


Lys Asn Leu Asp Thr Thr Pro Val Val Asn Gly Phe Ala Ser Val Pro 
465                 470                 475                 480 


Pro Phe Tyr Gln Leu Cys Phe Ile Pro Val 
                485                 490 


<210>  3879
<211>  282
<212>  PRT
<213>  Homo Sapiens

<400>  3879

Met Asp Ser Leu Val Val Leu Val Leu Cys Leu Ser Cys Leu Leu Leu 
1               5                   10                  15      


Leu Ser Leu Trp Arg Gln Ser Ser Gly Arg Gly Lys Leu Pro Pro Gly 
            20                  25                  30          


Pro Thr Pro Leu Pro Val Ile Gly Asn Ile Leu Gln Ile Gly Ile Lys 
        35                  40                  45              


Asp Ile Ser Lys Ser Leu Thr Asn Leu Ser Lys Val Tyr Gly Pro Val 
    50                  55                  60                  


Phe Thr Leu Tyr Phe Gly Leu Lys Pro Ile Val Val Leu His Gly Tyr 
65                  70                  75                  80  


Glu Ala Val Lys Glu Ala Leu Ile Asp Leu Gly Glu Glu Phe Ser Gly 
                85                  90                  95      


Arg Gly Ile Phe Pro Leu Ala Glu Arg Ala Asn Arg Gly Phe Gly Ile 
            100                 105                 110         


Val Phe Ser Asn Gly Lys Lys Trp Lys Glu Ile Arg Arg Phe Ser Leu 
        115                 120                 125             


Met Thr Leu Arg Asn Phe Gly Met Gly Lys Arg Ser Ile Glu Asp Arg 
    130                 135                 140                 


Val Gln Glu Glu Ala Arg Cys Leu Val Glu Glu Leu Arg Lys Thr Lys 
145                 150                 155                 160 


Ala Ser Pro Cys Asp Pro Thr Phe Ile Leu Gly Cys Ala Pro Cys Asn 
                165                 170                 175     


Val Ile Cys Ser Ile Ile Phe His Lys Arg Phe Asp Tyr Lys Asp Gln 
            180                 185                 190         


Gln Phe Leu Asn Leu Met Glu Lys Leu Asn Glu Asn Ile Lys Ile Leu 
        195                 200                 205             


Ser Ser Pro Trp Ile Gln Ile Cys Asn Asn Phe Ser Pro Ile Ile Asp 
    210                 215                 220                 


Tyr Phe Pro Gly Thr His Asn Lys Leu Leu Lys Asn Val Ala Phe Met 
225                 230                 235                 240 


Lys Ser Tyr Ile Leu Glu Lys Val Lys Glu His Gln Glu Ser Met Asp 
                245                 250                 255     


Met Asn Asn Pro Gln Asp Phe Ile Asp Cys Phe Leu Met Lys Met Glu 
            260                 265                 270         


Lys Leu Lys Ser Arg Lys Arg Leu Asn Val 
        275                 280         


<210>  3880
<211>  162
<212>  PRT
<213>  Homo Sapiens

<400>  3880

Met Asp Ser Leu Val Val Leu Val Leu Cys Leu Ser Cys Leu Leu Leu 
1               5                   10                  15      


Leu Ser Leu Trp Arg Gln Ser Ser Gly Arg Gly Lys Leu Pro Pro Gly 
            20                  25                  30          


Pro Thr Pro Leu Pro Val Ile Gly Asn Ile Leu Gln Ile Gly Ile Lys 
        35                  40                  45              


Asp Ile Ser Lys Ser Leu Thr Asn Leu Ser Lys Val Tyr Gly Pro Val 
    50                  55                  60                  


Phe Thr Leu Tyr Phe Gly Leu Lys Pro Ile Val Val Leu His Gly Tyr 
65                  70                  75                  80  


Glu Ala Val Lys Glu Ala Leu Ile Asp Leu Gly Glu Glu Phe Ser Gly 
                85                  90                  95      


Arg Gly Ile Phe Pro Leu Ala Glu Arg Ala Asn Arg Gly Phe Gly Ile 
            100                 105                 110         


Val Phe Ser Asn Gly Lys Lys Trp Lys Glu Ile Arg Arg Phe Ser Leu 
        115                 120                 125             


Met Thr Leu Arg Asn Phe Gly Met Gly Lys Arg Ser Ile Glu Asp Arg 
    130                 135                 140                 


Val Gln Glu Glu Ala Arg Cys Leu Val Glu Glu Leu Arg Lys Thr Lys 
145                 150                 155                 160 


Gly Gly 
        


<210>  3881
<211>  86
<212>  PRT
<213>  Homo Sapiens

<400>  3881

Met Ser Ala Leu Gly Val Thr Val Ala Leu Leu Val Trp Ala Ala Phe 
1               5                   10                  15      


Leu Leu Leu Val Ser Met Trp Arg Gln Val His Ser Ser Trp Asn Leu 
            20                  25                  30          


Pro Pro Gly Pro Phe Pro Leu Pro Ile Ile Gly Asn Leu Phe Gln Leu 
        35                  40                  45              


Glu Leu Lys Asn Ile Pro Lys Ser Phe Thr Arg Leu Ala Gln Arg Phe 
    50                  55                  60                  


Gly Pro Val Phe Thr Leu Tyr Val Gly Ser Gln Arg Met Val Val Met 
65                  70                  75                  80  


His Gly Tyr Lys Ala Val 
                85      


<210>  3882
<211>  493
<212>  PRT
<213>  Homo Sapiens

<400>  3882

Met Ser Ala Leu Gly Val Thr Val Ala Leu Leu Val Trp Ala Ala Phe 
1               5                   10                  15      


Leu Leu Leu Val Ser Met Trp Arg Gln Val His Ser Ser Trp Asn Leu 
            20                  25                  30          


Pro Pro Gly Pro Phe Pro Leu Pro Ile Ile Gly Asn Leu Phe Gln Leu 
        35                  40                  45              


Glu Leu Lys Asn Ile Pro Lys Ser Phe Thr Arg Leu Ala Gln Arg Phe 
    50                  55                  60                  


Gly Pro Val Phe Thr Leu Tyr Val Gly Ser Gln Arg Met Val Val Met 
65                  70                  75                  80  


His Gly Tyr Lys Ala Val Lys Glu Ala Leu Leu Asp Tyr Lys Asp Glu 
                85                  90                  95      


Phe Ser Gly Arg Gly Asp Leu Pro Ala Phe His Ala His Arg Asp Arg 
            100                 105                 110         


Gly Ile Ile Phe Asn Asn Gly Pro Thr Trp Lys Asp Ile Arg Arg Phe 
        115                 120                 125             


Ser Leu Thr Thr Leu Arg Asn Tyr Gly Met Gly Lys Gln Gly Asn Glu 
    130                 135                 140                 


Ser Arg Ile Gln Arg Glu Ala His Phe Leu Leu Glu Ala Leu Arg Lys 
145                 150                 155                 160 


Thr Gln Gly Gln Pro Phe Asp Pro Thr Phe Leu Ile Gly Cys Ala Pro 
                165                 170                 175     


Cys Asn Val Ile Ala Asp Ile Leu Phe Arg Lys His Phe Asp Tyr Asn 
            180                 185                 190         


Asp Glu Lys Phe Leu Arg Leu Met Tyr Leu Phe Asn Glu Asn Phe His 
        195                 200                 205             


Leu Leu Ser Thr Pro Trp Leu Gln Leu Tyr Asn Asn Phe Pro Ser Phe 
    210                 215                 220                 


Leu His Tyr Leu Pro Gly Ser His Arg Lys Val Ile Lys Asn Val Ala 
225                 230                 235                 240 


Glu Val Lys Glu Tyr Val Ser Glu Arg Val Lys Glu His His Gln Ser 
                245                 250                 255     


Leu Asp Pro Asn Cys Pro Arg Asp Leu Thr Asp Cys Leu Leu Val Glu 
            260                 265                 270         


Met Glu Lys Glu Lys His Ser Ala Glu Arg Leu Tyr Thr Met Asp Gly 
        275                 280                 285             


Ile Thr Val Thr Val Ala Asp Leu Phe Phe Ala Gly Thr Glu Thr Thr 
    290                 295                 300                 


Ser Thr Thr Leu Arg Tyr Gly Leu Leu Ile Leu Met Lys Tyr Pro Glu 
305                 310                 315                 320 


Ile Glu Glu Lys Leu His Glu Glu Ile Asp Arg Val Ile Gly Pro Ser 
                325                 330                 335     


Arg Ile Pro Ala Ile Lys Asp Arg Gln Glu Met Pro Tyr Met Asp Ala 
            340                 345                 350         


Val Val His Glu Ile Gln Arg Phe Ile Thr Leu Val Pro Ser Asn Leu 
        355                 360                 365             


Pro His Glu Ala Thr Arg Asp Thr Ile Phe Arg Gly Tyr Leu Ile Pro 
    370                 375                 380                 


Lys Gly Thr Val Val Val Pro Thr Leu Asp Ser Val Leu Tyr Asp Asn 
385                 390                 395                 400 


Gln Glu Phe Pro Asp Pro Glu Lys Phe Lys Pro Glu His Phe Leu Asn 
                405                 410                 415     


Glu Asn Gly Lys Phe Lys Tyr Ser Asp Tyr Phe Lys Pro Phe Ser Thr 
            420                 425                 430         


Gly Lys Arg Val Cys Ala Gly Glu Gly Leu Ala Arg Met Glu Leu Phe 
        435                 440                 445             


Leu Leu Leu Cys Ala Ile Leu Gln His Phe Asn Leu Lys Pro Leu Val 
    450                 455                 460                 


Asp Pro Lys Asp Ile Asp Leu Ser Pro Ile His Ile Gly Phe Gly Cys 
465                 470                 475                 480 


Ile Pro Pro Arg Tyr Lys Leu Cys Val Ile Pro Arg Ser 
                485                 490             


<210>  3883
<211>  493
<212>  PRT
<213>  Homo Sapiens

<400>  3883

Met Ser Ala Leu Gly Val Thr Val Ala Leu Leu Val Trp Ala Ala Phe 
1               5                   10                  15      


Leu Leu Leu Val Ser Met Trp Arg Gln Val His Ser Ser Trp Asn Leu 
            20                  25                  30          


Pro Pro Gly Pro Phe Pro Leu Pro Ile Ile Gly Asn Leu Phe Gln Leu 
        35                  40                  45              


Glu Leu Lys Asn Ile Pro Lys Ser Phe Thr Arg Leu Ala Gln Arg Phe 
    50                  55                  60                  


Gly Pro Val Phe Thr Leu Tyr Val Gly Ser Gln Arg Met Val Val Met 
65                  70                  75                  80  


His Gly Tyr Lys Ala Val Lys Glu Ala Leu Leu Asp Tyr Lys Asp Glu 
                85                  90                  95      


Phe Ser Gly Arg Gly Asp Leu Pro Ala Phe His Ala His Arg Asp Arg 
            100                 105                 110         


Gly Ile Ile Phe Asn Asn Gly Pro Thr Trp Lys Asp Ile Arg Arg Phe 
        115                 120                 125             


Ser Leu Thr Thr Leu Arg Asn Tyr Gly Met Gly Lys Gln Gly Asn Glu 
    130                 135                 140                 


Ser Arg Ile Gln Arg Glu Ala His Phe Leu Leu Glu Ala Leu Arg Lys 
145                 150                 155                 160 


Thr Gln Gly Gln Pro Phe Asp Pro Thr Phe Leu Ile Gly Cys Ala Pro 
                165                 170                 175     


Cys Asn Val Ile Ala Asp Ile Leu Phe Arg Lys His Phe Asp Tyr Asn 
            180                 185                 190         


Asp Glu Lys Phe Leu Arg Leu Met Tyr Leu Phe Asn Glu Asn Phe His 
        195                 200                 205             


Leu Leu Ser Thr Pro Trp Leu Gln Leu Tyr Asn Asn Phe Pro Ser Phe 
    210                 215                 220                 


Leu His Tyr Leu Pro Gly Ser His Arg Lys Val Ile Lys Asn Val Ala 
225                 230                 235                 240 


Glu Val Lys Glu Tyr Val Ser Glu Arg Val Lys Glu His His Gln Ser 
                245                 250                 255     


Leu Asp Pro Asn Cys Pro Arg Asp Leu Thr Asp Cys Leu Leu Val Glu 
            260                 265                 270         


Met Glu Lys Glu Lys His Ser Ala Glu Arg Leu Tyr Thr Met Asp Gly 
        275                 280                 285             


Ile Thr Val Thr Val Ala Asp Leu Phe Phe Ala Gly Thr Glu Thr Thr 
    290                 295                 300                 


Ser Thr Thr Leu Arg Tyr Gly Leu Leu Ile Leu Met Lys Tyr Pro Glu 
305                 310                 315                 320 


Ile Glu Glu Lys Leu His Glu Glu Ile Asp Arg Val Ile Gly Pro Ser 
                325                 330                 335     


Arg Ile Pro Ala Ile Lys Asp Arg Gln Glu Met Pro Tyr Met Asp Ala 
            340                 345                 350         


Val Val His Glu Ile Gln Arg Phe Ile Thr Leu Val Pro Ser Asn Leu 
        355                 360                 365             


Pro His Glu Ala Thr Arg Asp Thr Ile Phe Arg Gly Tyr Leu Ile Pro 
    370                 375                 380                 


Lys Gly Thr Val Val Val Pro Thr Leu Asp Ser Val Leu Tyr Asp Asn 
385                 390                 395                 400 


Gln Glu Phe Pro Asp Pro Glu Lys Phe Lys Pro Glu His Phe Leu Asn 
                405                 410                 415     


Glu Asn Gly Lys Phe Lys Tyr Ser Asp Tyr Phe Lys Pro Phe Ser Thr 
            420                 425                 430         


Gly Lys Arg Val Cys Ala Gly Glu Gly Leu Ala Arg Met Glu Leu Phe 
        435                 440                 445             


Leu Leu Leu Cys Ala Ile Leu Gln His Phe Asn Leu Lys Pro Leu Val 
    450                 455                 460                 


Asp Pro Lys Asp Ile Asp Leu Ser Pro Ile His Ile Gly Phe Gly Cys 
465                 470                 475                 480 


Ile Pro Pro Arg Tyr Lys Leu Cys Val Ile Pro Arg Ser 
                485                 490             


<210>  3884
<211>  356
<212>  PRT
<213>  Homo Sapiens

<400>  3884

Arg Pro Phe Pro Ala Ser His His Arg Glu Pro Leu Pro Val Gly Ile 
1               5                   10                  15      


Glu Glu Tyr Ser Gln Val Leu His Pro Gly Ile Ile Phe Asn Asn Gly 
            20                  25                  30          


Pro Thr Trp Lys Asp Ile Arg Arg Phe Ser Leu Thr Thr Leu Arg Asn 
        35                  40                  45              


Tyr Gly Met Gly Lys Gln Gly Asn Glu Ser Arg Ile Gln Arg Glu Ala 
    50                  55                  60                  


His Phe Leu Leu Glu Ala Leu Arg Lys Thr Gln Gly Gln Pro Phe Asp 
65                  70                  75                  80  


Pro Thr Phe Leu Ile Gly Cys Ala Pro Cys Asn Val Ile Ala Asp Ile 
                85                  90                  95      


Leu Phe Arg Lys His Phe Asp Tyr Asn Asp Glu Lys Phe Leu Arg Leu 
            100                 105                 110         


Met Tyr Leu Phe Asn Glu Asn Phe His Leu Leu Ser Thr Pro Trp Leu 
        115                 120                 125             


Gln Leu Tyr Asn Asn Phe Pro Ser Phe Leu His Tyr Leu Pro Gly Ser 
    130                 135                 140                 


His Arg Lys Val Ile Lys Asn Val Ala Glu Val Lys Glu Tyr Val Ser 
145                 150                 155                 160 


Glu Arg Val Lys Glu His His Gln Ser Leu Asp Pro Asn Cys Pro Arg 
                165                 170                 175     


Asp Leu Thr Asp Cys Leu Leu Val Glu Met Glu Lys Glu Lys His Ser 
            180                 185                 190         


Ala Glu Arg Leu Tyr Thr Met Asp Gly Ile Thr Val Thr Val Ala Asp 
        195                 200                 205             


Leu Phe Phe Ala Gly Thr Glu Thr Thr Ser Thr Thr Leu Arg Tyr Gly 
    210                 215                 220                 


Leu Leu Ile Leu Met Lys Tyr Pro Glu Ile Glu Glu Lys Leu His Glu 
225                 230                 235                 240 


Glu Ile Asp Arg Val Ile Gly Pro Ser Arg Ile Pro Ala Ile Lys Asp 
                245                 250                 255     


Arg Gln Glu Met Pro Tyr Met Asp Ala Val Val His Glu Ile Gln Arg 
            260                 265                 270         


Phe Ile Thr Leu Val Pro Ser Asn Leu Pro His Glu Ala Thr Arg Asp 
        275                 280                 285             


Thr Ile Phe Arg Gly Tyr Leu Ile Pro Lys Gly Thr Val Val Val Pro 
    290                 295                 300                 


Thr Leu Asp Ser Val Leu Tyr Asp Asn Gln Glu Phe Pro Asp Pro Glu 
305                 310                 315                 320 


Lys Phe Lys Pro Glu His Phe Leu Asn Glu Asn Gly Lys Phe Lys Tyr 
                325                 330                 335     


Ser Asp Tyr Phe Lys Pro Phe Ser Thr Gly Lys Arg Val Cys Ala Gly 
            340                 345                 350         


Glu Gly Leu Ala 
        355     


<210>  3885
<211>  306
<212>  PRT
<213>  Homo Sapiens

<400>  3885

Arg Pro Phe Pro Ala Ser His His Arg Glu Pro Leu Pro Val Gly Ile 
1               5                   10                  15      


Glu Glu Tyr Ser Gln Val Leu His Pro Gly Gln Pro Phe Asp Pro Thr 
            20                  25                  30          


Phe Leu Ile Gly Cys Ala Pro Cys Asn Val Ile Ala Asp Ile Leu Phe 
        35                  40                  45              


Arg Lys His Phe Asp Tyr Asn Asp Glu Lys Phe Leu Arg Leu Met Tyr 
    50                  55                  60                  


Leu Phe Asn Glu Asn Phe His Leu Leu Ser Thr Pro Trp Leu Gln Leu 
65                  70                  75                  80  


Tyr Asn Asn Phe Pro Ser Phe Leu His Tyr Leu Pro Gly Ser His Arg 
                85                  90                  95      


Lys Val Ile Lys Asn Val Ala Glu Val Lys Glu Tyr Val Ser Glu Arg 
            100                 105                 110         


Val Lys Glu His His Gln Ser Leu Asp Pro Asn Cys Pro Arg Asp Leu 
        115                 120                 125             


Thr Asp Cys Leu Leu Val Glu Met Glu Lys Glu Lys His Ser Ala Glu 
    130                 135                 140                 


Arg Leu Tyr Thr Met Asp Gly Ile Thr Val Thr Val Ala Asp Leu Phe 
145                 150                 155                 160 


Phe Ala Gly Thr Glu Thr Thr Ser Thr Thr Leu Arg Tyr Gly Leu Leu 
                165                 170                 175     


Ile Leu Met Lys Tyr Pro Glu Ile Glu Glu Lys Leu His Glu Glu Ile 
            180                 185                 190         


Asp Arg Val Ile Gly Pro Ser Arg Ile Pro Ala Ile Lys Asp Arg Gln 
        195                 200                 205             


Glu Met Pro Tyr Met Asp Ala Val Val His Glu Ile Gln Arg Phe Ile 
    210                 215                 220                 


Thr Leu Val Pro Ser Asn Leu Pro His Glu Ala Thr Arg Asp Thr Ile 
225                 230                 235                 240 


Phe Arg Gly Tyr Leu Ile Pro Lys Gly Thr Val Val Val Pro Thr Leu 
                245                 250                 255     


Asp Ser Val Leu Tyr Asp Asn Gln Glu Phe Pro Asp Pro Glu Lys Phe 
            260                 265                 270         


Lys Pro Glu His Phe Leu Asn Glu Asn Gly Lys Phe Lys Tyr Ser Asp 
        275                 280                 285             


Tyr Phe Lys Pro Phe Ser Thr Gly Lys Arg Val Cys Ala Gly Glu Gly 
    290                 295                 300                 


Leu Ala 
305     


<210>  3886
<211>  43
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3886

Xaa Gly Pro Phe Pro Leu Pro Ile Ile Gly Asn Leu Phe Gln Leu Glu 
1               5                   10                  15      


Leu Lys Asn Ile Pro Lys Ser Phe Thr Arg Glu Ser Phe Leu Ile Met 
            20                  25                  30          


Asp Leu Pro Gly Arg Thr Ser Gly Gly Phe Pro 
        35                  40              


<210>  3887
<211>  172
<212>  PRT
<213>  Homo Sapiens

<400>  3887

Ala Arg Val Gln Glu Glu Ile Asp Leu Val Val Gly Arg Ala Arg Leu 
1               5                   10                  15      


Pro Ala Leu Lys Asp Arg Ala Ala Met Pro Tyr Thr Asp Ala Val Ile 
            20                  25                  30          


His Glu Val Gln Arg Phe Ala Asp Ile Ile Pro Met Asn Leu Pro His 
        35                  40                  45              


Arg Val Thr Arg Asp Thr Ala Phe Arg Gly Phe Leu Ile Pro Lys Gly 
    50                  55                  60                  


Thr Asp Val Ile Thr Leu Leu Asn Thr Val His Tyr Asp Pro Ser Gln 
65                  70                  75                  80  


Phe Leu Thr Pro Gln Glu Phe Asn Pro Glu His Phe Leu Asp Ala Asn 
                85                  90                  95      


Gln Ser Phe Lys Lys Ser Pro Ala Phe Met Pro Phe Ser Ala Gly Glu 
            100                 105                 110         


Gly Arg Asn Gln Ser Leu Ser Gly Pro Ile Ser Thr Tyr Ile Pro His 
        115                 120                 125             


Pro Asn Ser Thr Cys Gln Ile Leu Ser Leu Leu Pro Ser Thr His Ser 
    130                 135                 140                 


Gln Leu Trp Met His Arg Asp Ile His Ser Ser Ser Gln Leu Cys Ser 
145                 150                 155                 160 


Tyr Arg Gln Val Val Thr Lys Ile Leu Val Lys Gln 
                165                 170         


<210>  3888
<211>  491
<212>  PRT
<213>  Homo Sapiens

<400>  3888

Met Asp Ser Ile Ser Thr Ala Ile Leu Leu Leu Leu Leu Ala Leu Val 
1               5                   10                  15      


Cys Leu Leu Leu Thr Leu Ser Ser Arg Asp Lys Gly Lys Leu Pro Pro 
            20                  25                  30          


Gly Pro Arg Pro Leu Ser Ile Leu Gly Asn Leu Leu Leu Leu Cys Ser 
        35                  40                  45              


Gln Asp Met Leu Thr Ser Leu Thr Lys Leu Ser Lys Glu Tyr Gly Ser 
    50                  55                  60                  


Met Tyr Thr Val His Leu Gly Pro Arg Arg Val Val Val Leu Ser Gly 
65                  70                  75                  80  


Tyr Gln Ala Val Lys Glu Ala Leu Val Asp Gln Gly Glu Glu Phe Ser 
                85                  90                  95      


Gly Arg Gly Asp Tyr Pro Ala Phe Phe Asn Phe Thr Lys Gly Asn Gly 
            100                 105                 110         


Ile Ala Phe Ser Ser Gly Asp Arg Trp Lys Val Leu Arg Gln Phe Ser 
        115                 120                 125             


Ile Gln Ile Leu Arg Asn Phe Gly Met Gly Lys Arg Ser Ile Glu Glu 
    130                 135                 140                 


Arg Ile Leu Glu Glu Gly Ser Phe Leu Leu Ala Glu Leu Arg Lys Thr 
145                 150                 155                 160 


Glu Gly Glu Pro Phe Asp Pro Thr Phe Val Leu Ser Arg Ser Val Ser 
                165                 170                 175     


Asn Ile Ile Cys Ser Val Leu Phe Gly Ser Arg Phe Asp Tyr Asp Asp 
            180                 185                 190         


Glu Arg Leu Leu Thr Ile Ile Arg Leu Ile Asn Asp Asn Phe Gln Ile 
        195                 200                 205             


Met Ser Ser Pro Trp Gly Glu Leu Tyr Asp Ile Phe Pro Ser Leu Leu 
    210                 215                 220                 


Asp Trp Val Pro Gly Pro His Gln Arg Ile Phe Gln Asn Phe Lys Cys 
225                 230                 235                 240 


Leu Arg Asp Leu Ile Ala His Ser Val His Asp His Gln Ala Ser Leu 
                245                 250                 255     


Asp Pro Arg Ser Pro Arg Asp Phe Ile Gln Cys Phe Leu Thr Lys Met 
            260                 265                 270         


Ala Glu Glu Lys Glu Asp Pro Leu Ser His Phe His Met Asp Thr Leu 
        275                 280                 285             


Leu Met Thr Thr His Asn Leu Leu Phe Gly Gly Thr Lys Thr Val Ser 
    290                 295                 300                 


Thr Thr Leu His His Ala Phe Leu Ala Leu Met Lys Tyr Pro Lys Val 
305                 310                 315                 320 


Gln Ala Arg Val Gln Glu Glu Ile Asp Leu Val Val Gly Arg Ala Arg 
                325                 330                 335     


Leu Pro Ala Leu Lys Asp Arg Ala Ala Met Pro Tyr Thr Asp Ala Val 
            340                 345                 350         


Ile His Glu Val Gln Arg Phe Ala Asp Ile Ile Pro Met Asn Leu Pro 
        355                 360                 365             


His Arg Val Thr Arg Asp Thr Ala Phe Arg Gly Phe Leu Ile Pro Lys 
    370                 375                 380                 


Gly Thr Asp Val Ile Thr Leu Leu Asn Thr Val His Tyr Asp Pro Ser 
385                 390                 395                 400 


Gln Phe Leu Thr Pro Gln Glu Phe Asn Pro Glu His Phe Leu Asp Ala 
                405                 410                 415     


Asn Gln Ser Phe Lys Lys Ser Pro Ala Phe Met Pro Phe Ser Ala Gly 
            420                 425                 430         


Arg Arg Leu Cys Leu Gly Glu Ser Leu Ala Arg Met Glu Leu Phe Leu 
        435                 440                 445             


Tyr Leu Thr Ala Ile Leu Gln Ser Phe Ser Leu Gln Pro Leu Gly Ala 
    450                 455                 460                 


Pro Glu Asp Ile Asp Leu Thr Pro Leu Ser Ser Gly Leu Gly Asn Leu 
465                 470                 475                 480 


Pro Arg Pro Phe Gln Leu Cys Leu Arg Pro Arg 
                485                 490     


<210>  3889
<211>  320
<212>  PRT
<213>  Homo Sapiens

<400>  3889

Met Asp Ser Ile Ser Thr Ala Ile Leu Leu Leu Leu Leu Ala Leu Val 
1               5                   10                  15      


Cys Leu Leu Leu Thr Leu Ser Ser Arg Asp Lys Gly Lys Leu Pro Pro 
            20                  25                  30          


Gly Pro Arg Pro Leu Ser Ile Leu Gly Asn Leu Leu Leu Leu Cys Ser 
        35                  40                  45              


Gln Asp Met Leu Thr Ser Leu Thr Lys Leu Ser Lys Glu Tyr Gly Ser 
    50                  55                  60                  


Met Tyr Thr Val His Leu Gly Pro Arg Arg Val Val Val Leu Ser Gly 
65                  70                  75                  80  


Tyr Gln Ala Val Lys Glu Ala Leu Val Asp Gln Gly Glu Glu Phe Ser 
                85                  90                  95      


Gly Arg Gly Asp Tyr Pro Ala Phe Phe Asn Phe Thr Lys Gly Asn Gly 
            100                 105                 110         


Ile Ala Phe Ser Ser Gly Asp Arg Trp Lys Val Leu Arg Gln Phe Ser 
        115                 120                 125             


Ile Gln Ile Leu Arg Asn Phe Gly Met Gly Lys Arg Ser Ile Glu Glu 
    130                 135                 140                 


Arg Ile Leu Glu Glu Gly Ser Phe Leu Leu Ala Glu Leu Arg Lys Thr 
145                 150                 155                 160 


Glu Gly Glu Pro Phe Asp Pro Thr Phe Val Leu Ser Arg Ser Val Ser 
                165                 170                 175     


Asn Ile Ile Cys Ser Val Leu Phe Gly Ser Arg Phe Asp Tyr Asp Asp 
            180                 185                 190         


Glu Arg Leu Leu Thr Ile Ile Arg Leu Ile Asn Asp Asn Phe Gln Ile 
        195                 200                 205             


Met Ser Ser Pro Trp Gly Glu Leu Tyr Asp Ile Phe Pro Ser Leu Leu 
    210                 215                 220                 


Asp Trp Val Pro Gly Pro His Gln Arg Ile Phe Gln Asn Phe Lys Cys 
225                 230                 235                 240 


Leu Arg Asp Leu Ile Ala His Ser Val His Asp His Gln Ala Ser Leu 
                245                 250                 255     


Asp Pro Arg Ser Pro Arg Asp Phe Ile Gln Cys Phe Leu Thr Lys Met 
            260                 265                 270         


Ala Glu Glu Lys Glu Asp Pro Leu Ser His Phe His Met Asp Thr Leu 
        275                 280                 285             


Leu Met Thr Thr His Asn Leu Leu Phe Gly Gly Thr Lys Thr Pro Ala 
    290                 295                 300                 


Cys Arg Arg Arg Ser Thr Ser Trp Trp Asp Ala Arg Gly Cys Arg Arg 
305                 310                 315                 320 


<210>  3890
<211>  81
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3890

Xaa Pro His Arg Val Thr Arg Asp Thr Ala Phe Arg Gly Phe Leu Ile 
1               5                   10                  15      


Pro Lys Gly Thr Asp Val Ile Thr Leu Leu Asn Thr Val His Tyr Asp 
            20                  25                  30          


Pro Ser Gln Phe Leu Thr Pro Gln Glu Phe Asn Pro Glu His Phe Leu 
        35                  40                  45              


Asp Ala Asn Gln Ser Phe Lys Lys Ser Pro Ala Phe Met Pro Phe Ser 
    50                  55                  60                  


Ala Ala Leu Asp Ala Gln Arg His Ser Phe Leu Leu Ser Thr Leu Leu 
65                  70                  75                  80  


Leu 
    


<210>  3891
<211>  502
<212>  PRT
<213>  Homo Sapiens

<400>  3891

Met Leu Ala Ala Met Gly Ser Leu Ala Ala Ala Leu Trp Ala Val Val 
1               5                   10                  15      


His Pro Arg Thr Leu Leu Leu Gly Thr Val Ala Phe Leu Leu Ala Ala 
            20                  25                  30          


Asp Phe Leu Lys Arg Arg Arg Pro Lys Asn Tyr Pro Pro Gly Pro Trp 
        35                  40                  45              


Arg Leu Pro Phe Leu Gly Asn Phe Phe Leu Val Asp Phe Glu Gln Ser 
    50                  55                  60                  


His Leu Glu Val Gln Leu Phe Val Lys Lys Tyr Gly Asn Leu Phe Ser 
65                  70                  75                  80  


Leu Glu Leu Gly Asp Ile Ser Ala Val Leu Ile Thr Gly Leu Pro Leu 
                85                  90                  95      


Ile Lys Glu Ala Leu Ile His Met Asp Gln Asn Phe Gly Asn Arg Pro 
            100                 105                 110         


Val Thr Pro Met Arg Glu His Ile Phe Lys Lys Asn Gly Leu Ile Met 
        115                 120                 125             


Ser Ser Gly Gln Ala Trp Lys Glu Gln Arg Arg Phe Thr Leu Thr Ala 
    130                 135                 140                 


Leu Arg Asn Phe Gly Leu Gly Lys Lys Ser Leu Glu Glu Arg Ile Gln 
145                 150                 155                 160 


Glu Glu Ala Gln His Leu Thr Glu Ala Ile Lys Glu Glu Asn Gly Gln 
                165                 170                 175     


Pro Phe Asp Pro His Phe Lys Ile Asn Asn Ala Val Ser Asn Ile Ile 
            180                 185                 190         


Cys Ser Ile Thr Phe Gly Glu Arg Phe Glu Tyr Gln Asp Ser Trp Phe 
        195                 200                 205             


Gln Gln Leu Leu Lys Leu Leu Asp Glu Val Thr Tyr Leu Glu Ala Ser 
    210                 215                 220                 


Lys Thr Cys Gln Leu Tyr Asn Val Phe Pro Trp Ile Met Lys Phe Leu 
225                 230                 235                 240 


Pro Gly Pro His Gln Thr Leu Phe Ser Asn Trp Lys Lys Leu Lys Leu 
                245                 250                 255     


Phe Val Ser His Met Ile Asp Lys His Arg Lys Asp Trp Asn Pro Ala 
            260                 265                 270         


Glu Thr Arg Asp Phe Ile Asp Ala Tyr Leu Lys Glu Met Ser Lys His 
        275                 280                 285             


Thr Gly Asn Pro Thr Ser Ser Phe His Glu Glu Asn Leu Ile Cys Ser 
    290                 295                 300                 


Thr Leu Asp Leu Phe Phe Ala Gly Thr Glu Thr Thr Ser Thr Thr Leu 
305                 310                 315                 320 


Arg Trp Ala Leu Leu Tyr Met Ala Leu Tyr Pro Glu Ile Gln Glu Lys 
                325                 330                 335     


Val Gln Ala Glu Ile Asp Arg Val Ile Gly Gln Gly Gln Gln Pro Ser 
            340                 345                 350         


Thr Ala Ala Arg Glu Ser Met Pro Tyr Thr Asn Ala Val Ile His Glu 
        355                 360                 365             


Val Gln Arg Met Gly Asn Ile Ile Pro Leu Asn Val Pro Arg Glu Val 
    370                 375                 380                 


Thr Val Asp Thr Thr Leu Ala Gly Tyr His Leu Pro Lys Gly Thr Met 
385                 390                 395                 400 


Ile Leu Thr Asn Leu Thr Ala Leu His Arg Asp Pro Thr Glu Trp Ala 
                405                 410                 415     


Thr Pro Asp Thr Phe Asn Pro Asp His Phe Leu Glu Asn Gly Gln Phe 
            420                 425                 430         


Lys Lys Arg Glu Ala Phe Met Pro Phe Ser Ile Gly Lys Arg Ala Cys 
        435                 440                 445             


Leu Gly Glu Gln Leu Ala Arg Thr Glu Leu Phe Ile Phe Phe Thr Ser 
    450                 455                 460                 


Leu Met Gln Lys Phe Thr Phe Arg Pro Pro Asn Asn Glu Lys Leu Ser 
465                 470                 475                 480 


Leu Lys Phe Arg Met Gly Ile Thr Ile Ser Pro Val Ser His Arg Leu 
                485                 490                 495     


Cys Ala Val Pro Gln Val 
            500         


<210>  3892
<211>  268
<212>  PRT
<213>  Homo Sapiens

<400>  3892

Met Pro Cys Ser Ser Lys Arg Asn Phe Cys Arg Gln Thr Met Pro Ser 
1               5                   10                  15      


Phe Ile His Glu Asp Asp Lys Asn Gly Arg Leu Ile Glu Lys Ala Ser 
            20                  25                  30          


Val Asn Arg Lys Pro Gln Leu Pro Gln His Phe Val Asp Ala Tyr Leu 
        35                  40                  45              


Asp Glu Met Asp Gln Gly Lys Asn Asp Pro Ser Ser Thr Phe Ser Lys 
    50                  55                  60                  


Glu Asn Leu Ile Phe Ser Val Gly Glu Leu Ile Ile Ala Gly Thr Glu 
65                  70                  75                  80  


Thr Thr Thr Asn Val Leu Arg Trp Ala Ile Leu Phe Met Ala Leu Tyr 
                85                  90                  95      


Pro Asn Ile Gln Gly Gln Val Gln Lys Glu Ile Asp Leu Ile Met Gly 
            100                 105                 110         


Pro Asn Gly Lys Pro Ser Trp Asp Asp Lys Cys Lys Met Pro Tyr Thr 
        115                 120                 125             


Glu Ala Val Leu His Glu Val Leu Arg Phe Cys Asn Ile Val Pro Leu 
    130                 135                 140                 


Gly Ile Phe His Ala Thr Ser Glu Asp Ala Val Val Arg Gly Tyr Ser 
145                 150                 155                 160 


Ile Pro Lys Gly Thr Thr Val Ile Thr Asn Leu Tyr Ser Val His Phe 
                165                 170                 175     


Asp Glu Lys Tyr Trp Arg Asp Pro Glu Val Phe His Pro Glu Arg Phe 
            180                 185                 190         


Leu Asp Ser Ser Gly Tyr Phe Ala Lys Lys Glu Ala Leu Val Pro Phe 
        195                 200                 205             


Ser Leu Gly Arg Arg His Cys Leu Gly Glu His Leu Ala Arg Met Glu 
    210                 215                 220                 


Met Phe Leu Phe Phe Thr Ala Leu Leu Gln Arg Phe His Leu His Phe 
225                 230                 235                 240 


Pro His Glu Leu Val Pro Asp Leu Lys Pro Arg Leu Gly Met Thr Leu 
                245                 250                 255     


Gln Pro Gln Pro Tyr Leu Ile Cys Ala Glu Arg Arg 
            260                 265             


<210>  3893
<211>  37
<212>  PRT
<213>  Homo Sapiens

<400>  3893

Met Pro Cys Ser Ser Lys Arg Asn Phe Cys Arg Gln Thr Met Pro Ser 
1               5                   10                  15      


Phe Ile His Glu Asp Asp Lys Asn Gly Arg Leu Thr Gln Phe Gln Ile 
            20                  25                  30          


Trp Pro Arg Met Gly 
        35          


<210>  3894
<211>  37
<212>  PRT
<213>  Homo Sapiens

<400>  3894

Met Pro Cys Ser Ser Lys Arg Asn Phe Cys Arg Gln Thr Met Pro Ser 
1               5                   10                  15      


Phe Ile His Glu Asp Asp Lys Asn Gly Arg Leu Thr Gln Phe Gln Ile 
            20                  25                  30          


Trp Pro Arg Met Gly 
        35          


<210>  3895
<211>  37
<212>  PRT
<213>  Homo Sapiens

<400>  3895

Met Pro Cys Ser Ser Lys Arg Asn Phe Cys Arg Gln Thr Met Pro Ser 
1               5                   10                  15      


Phe Ile His Glu Asp Asp Lys Asn Gly Arg Leu Thr Gln Phe Gln Ile 
            20                  25                  30          


Trp Pro Arg Met Gly 
        35          


<210>  3896
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  3896

Met Trp Lys Leu Trp Arg Ala Glu Glu Gly Ala Ala Ala Leu Gly Gly 
1               5                   10                  15      


Ala Leu Phe Leu Leu Leu Phe Ala Leu Gly Val Arg Gln Leu Leu Lys 
            20                  25                  30          


Gln Arg Arg Pro Met Gly Phe Pro Pro Gly Pro Pro Gly Leu Pro Phe 
        35                  40                  45              


Ile Gly Asn Ile Tyr Ser Leu Ala Ala Ser Ser Glu Leu Pro His Val 
    50                  55                  60                  


Tyr Met Arg Lys Gln Ser Gln Val Tyr Gly Glu Ile Phe Ser Leu Asp 
65                  70                  75                  80  


Leu Gly Gly Ile Ser Thr Val Val Leu Asn Gly Tyr Asp Val Val Lys 
                85                  90                  95      


Glu Cys Leu Val His Gln Ser Glu Ile Phe Ala Asp Arg Pro Cys Leu 
            100                 105                 110         


Pro Leu Phe Met Lys Met Thr Lys Met Gly Gly Leu Leu Asn Ser Arg 
        115                 120                 125             


Tyr Gly Arg Gly Trp Val Asp His Arg Arg Leu Ala Val Asn Ser Phe 
    130                 135                 140                 


Arg Tyr Phe Gly Tyr Gly Gln Lys Ser Phe Glu Ser Lys Ile Leu Glu 
145                 150                 155                 160 


Glu Thr Lys Phe Phe Asn Asp Ala Ile Glu Thr Tyr Lys Gly Arg Pro 
                165                 170                 175     


Phe Asp Phe Lys Gln Leu Ile Thr Asn Ala Val Ser Asn Ile Thr Asn 
            180                 185                 190         


Leu Ile Ile Phe Gly Glu Arg Phe Thr Tyr Glu Asp Thr Asp Phe Gln 
        195                 200                 205             


His Met Ile Glu Leu Phe Ser Glu Asn Val Glu Leu Ala Ala Ser Ala 
    210                 215                 220                 


Ser Val Phe Leu Tyr Asn Ala Phe Pro Trp Ile Gly Ile Leu Pro Phe 
225                 230                 235                 240 


Gly Lys His Gln Gln Leu Phe Arg Asn Ala Ala Val Val Tyr Asp Phe 
                245                 250                 255     


Leu Ser Arg Leu Ile Glu Lys Ala Ser Val Asn Arg Lys Pro Gln Leu 
            260                 265                 270         


Pro Gln His Phe Val Asp Ala Tyr Leu Asp Glu Met Asp Gln Gly Lys 
        275                 280                 285             


Asn Asp Pro Ser Ser Thr Phe Ser Lys Glu Asn Leu Ile Phe Ser Val 
    290                 295                 300                 


Gly Glu Leu Ile Ile Ala Gly Thr Glu Thr Thr Thr Asn Val Leu Arg 
305                 310                 315                 320 


Trp Ala Ile Leu Phe Met Ala Leu Tyr Pro Asn Ile Gln Gly Gln Val 
                325                 330                 335     


Gln Lys Glu Ile Asp Leu Ile Met Gly Pro Asn Gly Lys Pro Ser Trp 
            340                 345                 350         


Asp Asp Lys Cys Lys Met Pro Tyr Thr Glu Ala Val Leu His Glu Val 
        355                 360                 365             


Leu Arg Phe Cys Asn Ile Val Pro Leu Gly Ile Phe His Ala Thr Ser 
    370                 375                 380                 


Glu Asp Ala Val Val Arg Gly Tyr Ser Ile Pro Lys Gly Thr Thr Val 
385                 390                 395                 400 


Ile Thr Asn Leu Tyr Ser Val His Phe Asp Glu Lys Tyr Trp Arg Asp 
                405                 410                 415     


Pro Glu Val Phe His Pro Glu Arg Phe Leu Asp Ser Ser Gly Tyr Phe 
            420                 425                 430         


Ala Lys Lys Glu Ala Leu Val Pro Phe Ser Leu Gly Arg Arg His Cys 
        435                 440                 445             


Leu Gly Glu His Leu Ala Arg Met Glu Met Phe Leu Phe Phe Thr Ala 
    450                 455                 460                 


Leu Leu Gln Arg Phe His Leu His Phe Pro His Glu Leu Val Pro Asp 
465                 470                 475                 480 


Leu Lys Pro Arg Leu Gly Met Thr Leu Gln Pro Gln Pro Tyr Leu Ile 
                485                 490                 495     


Cys Ala Glu Arg Arg 
            500     


<210>  3897
<211>  32
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3897

Xaa Gln Ser Glu Ile Phe Ala Asp Arg Pro Cys Leu Pro Leu Phe Met 
1               5                   10                  15      


Lys Met Thr Lys Met Gly Val Leu Glu Arg Pro Arg Ser Val Pro Ser 
            20                  25                  30          


<210>  3898
<211>  73
<212>  PRT
<213>  Homo Sapiens

<400>  3898

Ala Val Cys Trp Asp Asp Asp Gly Gln His His Gly Arg Leu Tyr Pro 
1               5                   10                  15      


Pro Ala Pro Asp Glu Ile Pro Ser Cys Pro Lys Ala Arg Arg Ser Ser 
            20                  25                  30          


Pro Ser Leu Ala Pro Ser Cys Met Thr Pro Thr Ser Ser Ser Thr Gln 
        35                  40                  45              


Lys Ser Ser Thr Gln Thr Val Ser Trp Met Gln Met Asp Gly Ser Gly 
    50                  55                  60                  


Ser Met Arg Arg Ser Cys Pro Ser Pro 
65                  70              


<210>  3899
<211>  175
<212>  PRT
<213>  Homo Sapiens

<400>  3899

Met Glu Ala Thr Gly Thr Trp Ala Leu Leu Leu Ala Leu Ala Leu Leu 
1               5                   10                  15      


Leu Leu Leu Thr Leu Ala Leu Ser Gly Thr Arg Ala Arg Gly His Leu 
            20                  25                  30          


Pro Pro Gly Pro Thr Pro Leu Pro Leu Leu Gly Asn Leu Leu Gln Leu 
        35                  40                  45              


Arg Pro Gly Ala Leu Tyr Ser Gly Leu Met Arg Glu Glu Gln Asn Pro 
    50                  55                  60                  


Gly Thr Glu Phe Thr Asn Lys Asn Met Leu Met Thr Val Ile Tyr Leu 
65                  70                  75                  80  


Leu Phe Ala Gly Thr Met Thr Val Ser Thr Thr Val Gly Tyr Thr Leu 
                85                  90                  95      


Leu Leu Leu Met Lys Tyr Pro His Val Gln Lys Trp Val Arg Glu Glu 
            100                 105                 110         


Leu Asn Arg Glu Leu Gly Ala Gly Gln Ala Pro Ser Leu Gly Asp Arg 
        115                 120                 125             


Thr Arg Leu Pro Tyr Thr Asp Ala Val Leu His Glu Ala Gln Arg Leu 
    130                 135                 140                 


Leu Ala Leu Val Pro Met Gly Ile Pro Arg Thr Leu Met Arg Thr Thr 
145                 150                 155                 160 


Arg Phe Arg Gly Tyr Thr Leu Pro Gln Gly Thr Glu Val Phe Pro 
                165                 170                 175 


<210>  3900
<211>  165
<212>  PRT
<213>  Homo Sapiens

<400>  3900

Met Glu Ala Thr Gly Thr Trp Ala Leu Leu Leu Ala Leu Ala Leu Leu 
1               5                   10                  15      


Leu Leu Leu Thr Leu Ala Leu Ser Gly Thr Arg Ala Arg Gly His Leu 
            20                  25                  30          


Pro Pro Gly Pro Thr Pro Leu Pro Leu Leu Gly Asn Leu Leu Gln Leu 
        35                  40                  45              


Arg Pro Gly Ala Leu Tyr Ser Gly Leu Met Arg Leu Ser Lys Lys Tyr 
    50                  55                  60                  


Gly Pro Val Phe Thr Ile Tyr Leu Gly Pro Trp Arg Pro Val Val Val 
65                  70                  75                  80  


Leu Val Gly Gln Glu Ala Val Arg Glu Ala Leu Gly Gly Gln Ala Glu 
                85                  90                  95      


Glu Phe Ser Gly Arg Gly Thr Val Ala Met Leu Glu Gly Thr Phe Asp 
            100                 105                 110         


Gly His Gly Gly Thr Lys Pro Arg His Arg Ile His Gln Gln Glu His 
        115                 120                 125             


Ala Asp Asp Ser His Leu Phe Ala Val Cys Trp Asp Asp Asp Gly Gln 
    130                 135                 140                 


His His Gly Arg Leu Tyr Pro Pro Ala Pro Asp Glu Ile Pro Ser Cys 
145                 150                 155                 160 


Pro Lys Val Gly Thr 
                165 


<210>  3901
<211>  187
<212>  PRT
<213>  Homo Sapiens

<400>  3901

Met Glu Ala Thr Gly Thr Trp Ala Leu Leu Leu Ala Leu Ala Leu Leu 
1               5                   10                  15      


Leu Leu Leu Thr Leu Ala Leu Ser Gly Thr Arg Ala Arg Gly His Leu 
            20                  25                  30          


Pro Pro Gly Pro Thr Pro Leu Pro Leu Leu Gly Asn Leu Leu Gln Leu 
        35                  40                  45              


Arg Pro Gly Ala Leu Tyr Ser Gly Leu Met Arg Leu Ser Lys Lys Tyr 
    50                  55                  60                  


Gly Pro Val Phe Thr Ile Tyr Leu Gly Pro Trp Arg Pro Val Val Val 
65                  70                  75                  80  


Leu Val Gly Gln Glu Ala Val Arg Glu Ala Leu Gly Gly Gln Ala Glu 
                85                  90                  95      


Glu Phe Ser Gly Arg Gly Thr Val Ala Met Leu Glu Gly Thr Phe Asp 
            100                 105                 110         


Gly His Gly Val Phe Phe Ser Asn Gly Glu Arg Trp Arg Gln Leu Arg 
        115                 120                 125             


Lys Phe Thr Met Leu Ala Leu Arg Asp Leu Gly Met Gly Lys Arg Glu 
    130                 135                 140                 


Gly Glu Glu Leu Ile Gln Ala Glu Ala Arg Cys Leu Val Glu Thr Phe 
145                 150                 155                 160 


Gln Gly Thr Glu Gly Gly Thr Lys Pro Arg His Arg Ile His Gln Gln 
                165                 170                 175     


Glu His Ala Asp Asp Ser His Leu Phe Ala Val 
            180                 185         


<210>  3902
<211>  504
<212>  PRT
<213>  Homo Sapiens

<400>  3902

Met Glu Ala Thr Gly Thr Trp Ala Leu Leu Leu Ala Leu Ala Leu Leu 
1               5                   10                  15      


Leu Leu Leu Thr Leu Ala Leu Ser Gly Thr Arg Ala Arg Gly His Leu 
            20                  25                  30          


Pro Pro Gly Pro Thr Pro Leu Pro Leu Leu Gly Asn Leu Leu Gln Leu 
        35                  40                  45              


Arg Pro Gly Ala Leu Tyr Ser Gly Leu Met Arg Leu Ser Lys Lys Tyr 
    50                  55                  60                  


Gly Pro Val Phe Thr Ile Tyr Leu Gly Pro Trp Arg Pro Val Val Val 
65                  70                  75                  80  


Leu Val Gly Gln Glu Ala Val Arg Glu Ala Leu Gly Gly Gln Ala Glu 
                85                  90                  95      


Glu Phe Ser Gly Arg Gly Thr Val Ala Met Leu Glu Gly Thr Phe Asp 
            100                 105                 110         


Gly His Gly Val Phe Phe Ser Asn Gly Glu Arg Trp Arg Gln Leu Arg 
        115                 120                 125             


Lys Phe Thr Met Leu Ala Leu Arg Asp Leu Gly Met Gly Lys Arg Glu 
    130                 135                 140                 


Gly Glu Glu Leu Ile Gln Ala Glu Ala Arg Cys Leu Val Glu Thr Phe 
145                 150                 155                 160 


Gln Gly Thr Glu Gly Arg Pro Phe Asp Pro Ser Leu Leu Leu Ala Gln 
                165                 170                 175     


Ala Thr Ser Asn Val Val Cys Ser Leu Leu Phe Gly Leu Arg Phe Ser 
            180                 185                 190         


Tyr Glu Asp Lys Glu Phe Gln Ala Val Val Arg Ala Ala Gly Gly Thr 
        195                 200                 205             


Leu Leu Gly Val Ser Ser Gln Gly Gly Gln Thr Tyr Glu Met Phe Ser 
    210                 215                 220                 


Trp Phe Leu Arg Pro Leu Pro Gly Pro His Lys Gln Leu Leu His His 
225                 230                 235                 240 


Val Ser Thr Leu Ala Ala Phe Thr Val Arg Gln Val Gln Gln His Gln 
                245                 250                 255     


Gly Asn Leu Asp Ala Ser Gly Pro Ala Arg Asp Leu Val Asp Ala Phe 
            260                 265                 270         


Leu Leu Lys Met Ala Gln Glu Glu Gln Asn Pro Gly Thr Glu Phe Thr 
        275                 280                 285             


Asn Lys Asn Met Leu Met Thr Val Ile Tyr Leu Leu Phe Ala Gly Thr 
    290                 295                 300                 


Met Thr Val Ser Thr Thr Val Gly Tyr Thr Leu Leu Leu Leu Met Lys 
305                 310                 315                 320 


Tyr Pro His Val Gln Lys Trp Val Arg Glu Glu Leu Asn Arg Glu Leu 
                325                 330                 335     


Gly Ala Gly Gln Ala Pro Ser Leu Gly Asp Arg Thr Arg Leu Pro Tyr 
            340                 345                 350         


Thr Asp Ala Val Leu His Glu Ala Gln Arg Leu Leu Ala Leu Val Pro 
        355                 360                 365             


Met Gly Ile Pro Arg Thr Leu Met Arg Thr Thr Arg Phe Arg Gly Tyr 
    370                 375                 380                 


Thr Leu Pro Gln Gly Thr Glu Val Phe Pro Leu Leu Gly Ser Ile Leu 
385                 390                 395                 400 


His Asp Pro Asn Ile Phe Lys His Pro Glu Glu Phe Asn Pro Asp Arg 
                405                 410                 415     


Phe Leu Asp Ala Asp Gly Arg Phe Arg Lys His Glu Ala Phe Leu Pro 
            420                 425                 430         


Phe Ser Leu Gly Lys Arg Val Cys Leu Gly Glu Gly Leu Ala Lys Ala 
        435                 440                 445             


Glu Leu Phe Leu Phe Phe Thr Thr Ile Leu Gln Ala Phe Ser Leu Glu 
    450                 455                 460                 


Ser Pro Cys Pro Pro Asp Thr Leu Ser Leu Lys Pro Thr Val Ser Gly 
465                 470                 475                 480 


Leu Phe Asn Ile Pro Pro Ala Phe Gln Leu Gln Val Arg Pro Thr Asp 
                485                 490                 495     


Leu His Ser Thr Thr Gln Thr Arg 
            500                 


<210>  3903
<211>  60
<212>  PRT
<213>  Homo Sapiens

<400>  3903

Met Leu Glu Gly Thr Phe Asp Gly His Gly Gly Thr Lys Pro Arg His 
1               5                   10                  15      


Arg Ile His Gln Gln Glu His Ala Asp Asp Ser His Leu Phe Ala Val 
            20                  25                  30          


Cys Trp Asp Asp Asp Gly Gln His His Gly Arg Leu Tyr Pro Pro Ala 
        35                  40                  45              


Pro Asp Glu Ile Pro Ser Cys Pro Lys Val Gly Thr 
    50                  55                  60  


<210>  3904
<211>  288
<212>  PRT
<213>  Homo Sapiens

<400>  3904

Leu Gln Leu His Arg Pro Val Leu Arg Lys Ile Glu Glu Val Arg Ala 
1               5                   10                  15      


Ile Leu Arg Thr Leu Leu Glu Ala Arg Arg Pro His Val Cys Pro Gly 
            20                  25                  30          


Asp Pro Val Cys Ser Tyr Val Asp Ala Leu Ile Gln Gln Gly Gln Gly 
        35                  40                  45              


Asp Asp Pro Glu Gly Leu Phe Ala Glu Ala Asn Ala Val Ala Cys Thr 
    50                  55                  60                  


Leu Asp Met Val Met Ala Gly Thr Glu Thr Thr Ser Ala Thr Leu Gln 
65                  70                  75                  80  


Trp Ala Ala Leu Leu Met Gly Arg His Pro Asp Val Gln Gly Arg Val 
                85                  90                  95      


Gln Glu Glu Leu Asp Arg Val Leu Gly Pro Gly Arg Thr Pro Arg Leu 
            100                 105                 110         


Glu Asp Gln Gln Ala Leu Pro Tyr Thr Ser Ala Val Leu His Glu Val 
        115                 120                 125             


Gln Arg Phe Ile Thr Leu Leu Pro His Val Pro Arg Cys Thr Ala Ala 
    130                 135                 140                 


Asp Thr Gln Leu Gly Gly Phe Leu Leu Pro Lys Gly Thr Pro Val Ile 
145                 150                 155                 160 


Pro Leu Leu Thr Ser Val Leu Leu Asp Glu Thr Gln Trp Gln Thr Pro 
                165                 170                 175     


Gly Gln Phe Asn Pro Gly His Phe Leu Asp Ala Asn Gly His Phe Val 
            180                 185                 190         


Lys Arg Glu Ala Phe Leu Pro Phe Ser Ala Gly Ser Glu Gly Gly Cys 
        195                 200                 205             


Gly Gly Cys Ser Cys Ala Pro Leu Gly Arg Ser Pro Pro Leu Pro Ser 
    210                 215                 220                 


Arg Ser Arg Pro Gly Ala Ala His Ser Val Pro Gly His Pro Pro Gln 
225                 230                 235                 240 


Ala Ala Ala Ser Val Leu Gly Ser Ala Trp Pro Gly Pro Ser Ser Ser 
                245                 250                 255     


Cys Cys Leu Pro Ala Ser Cys Arg Gly Thr Ala Cys Cys Pro Arg Leu 
            260                 265                 270         


Ala Ser Val Arg Pro Pro Trp Thr Pro Arg Pro Pro Gly Leu Leu Pro 
        275                 280                 285             


<210>  3905
<211>  490
<212>  PRT
<213>  Homo Sapiens

<400>  3905

Met Ala Leu Leu Leu Leu Leu Phe Leu Gly Leu Leu Gly Leu Trp Gly 
1               5                   10                  15      


Leu Leu Cys Ala Cys Ala Gln Asp Pro Ser Pro Ala Ala Arg Trp Pro 
            20                  25                  30          


Pro Gly Pro Arg Pro Leu Pro Leu Val Gly Asn Leu His Leu Leu Arg 
        35                  40                  45              


Leu Ser Gln Gln Asp Arg Ser Leu Met Glu Leu Ser Glu Arg Tyr Gly 
    50                  55                  60                  


Pro Val Phe Thr Val His Leu Gly Arg Gln Lys Thr Val Val Leu Thr 
65                  70                  75                  80  


Gly Phe Glu Ala Val Lys Glu Ala Leu Ala Gly Pro Gly Gln Glu Leu 
                85                  90                  95      


Ala Asp Arg Pro Pro Ile Ala Ile Phe Gln Leu Ile Gln Arg Gly Gly 
            100                 105                 110         


Gly Ile Phe Phe Ser Ser Gly Ala Arg Trp Arg Ala Ala Arg Gln Phe 
        115                 120                 125             


Thr Val Arg Ala Leu His Ser Leu Gly Val Gly Arg Glu Pro Val Ala 
    130                 135                 140                 


Asp Lys Ile Leu Gln Glu Leu Lys Cys Leu Ser Gly Gln Leu Asp Gly 
145                 150                 155                 160 


Tyr Arg Gly Arg Pro Phe Pro Leu Ala Leu Leu Gly Trp Ala Pro Ser 
                165                 170                 175     


Asn Ile Thr Phe Ala Leu Leu Phe Gly Arg Arg Phe Asp Tyr Arg Asp 
            180                 185                 190         


Pro Val Phe Val Ser Leu Leu Gly Leu Ile Asp Glu Val Met Val Leu 
        195                 200                 205             


Leu Gly Ser Pro Gly Leu Gln Leu Phe Asn Val Tyr Pro Trp Leu Gly 
    210                 215                 220                 


Ala Leu Leu Gln Leu His Arg Pro Val Leu Arg Lys Ile Glu Glu Val 
225                 230                 235                 240 


Arg Ala Ile Leu Arg Thr Leu Leu Glu Ala Arg Arg Pro His Val Cys 
                245                 250                 255     


Pro Gly Asp Pro Val Cys Ser Tyr Val Asp Ala Leu Ile Gln Gln Gly 
            260                 265                 270         


Gln Gly Asp Asp Pro Glu Gly Leu Phe Ala Glu Ala Asn Ala Val Ala 
        275                 280                 285             


Cys Thr Leu Asp Met Val Met Ala Gly Thr Glu Thr Thr Ser Ala Thr 
    290                 295                 300                 


Leu Gln Trp Ala Ala Leu Leu Met Gly Arg His Pro Asp Val Gln Gly 
305                 310                 315                 320 


Arg Val Gln Glu Glu Leu Asp Arg Val Leu Gly Pro Gly Arg Thr Pro 
                325                 330                 335     


Arg Leu Glu Asp Gln Gln Ala Leu Pro Tyr Thr Ser Ala Val Leu His 
            340                 345                 350         


Glu Val Gln Arg Phe Ile Thr Leu Leu Pro His Val Pro Arg Cys Thr 
        355                 360                 365             


Ala Ala Asp Thr Gln Leu Gly Gly Phe Leu Leu Pro Lys Gly Thr Pro 
    370                 375                 380                 


Val Ile Pro Leu Leu Thr Ser Val Leu Leu Asp Glu Thr Gln Trp Gln 
385                 390                 395                 400 


Thr Pro Gly Gln Phe Asn Pro Gly His Phe Leu Asp Ala Asn Gly His 
                405                 410                 415     


Phe Val Lys Arg Glu Ala Phe Leu Pro Phe Ser Ala Gly Arg Arg Val 
            420                 425                 430         


Cys Val Gly Glu Arg Leu Ala Arg Thr Glu Leu Phe Leu Leu Phe Ala 
        435                 440                 445             


Gly Leu Leu Gln Arg Tyr Arg Leu Leu Pro Pro Pro Gly Val Ser Pro 
    450                 455                 460                 


Ala Ser Leu Asp Thr Thr Pro Ala Arg Ala Phe Thr Met Arg Pro Arg 
465                 470                 475                 480 


Ala Gln Ala Leu Cys Ala Val Pro Arg Pro 
                485                 490 


<210>  3906
<211>  408
<212>  PRT
<213>  Homo Sapiens

<400>  3906

Met Glu Leu Ser Glu Arg Tyr Gly Pro Val Phe Thr Val His Leu Gly 
1               5                   10                  15      


Arg Gln Lys Thr Val Val Leu Thr Gly Phe Glu Ala Val Lys Glu Ala 
            20                  25                  30          


Leu Ala Gly Pro Gly Gln Glu Leu Ala Asp Arg Pro Pro Ile Ala Ile 
        35                  40                  45              


Phe Gln Leu Ile Gln Arg Gly Gly Gly Ile Phe Phe Ser Ser Gly Ala 
    50                  55                  60                  


Arg Trp Arg Ala Ala Arg Gln Phe Thr Val Arg Ala Leu His Ser Leu 
65                  70                  75                  80  


Gly Val Gly Arg Glu Pro Val Ala Asp Lys Ile Leu Gln Glu Leu Lys 
                85                  90                  95      


Cys Leu Ser Gly Gln Leu Asp Gly Tyr Arg Gly Arg Pro Phe Pro Leu 
            100                 105                 110         


Ala Leu Leu Gly Trp Ala Pro Ser Asn Ile Thr Phe Ala Leu Leu Phe 
        115                 120                 125             


Gly Arg Arg Phe Asp Tyr Arg Asp Pro Val Phe Val Ser Leu Leu Gly 
    130                 135                 140                 


Leu Ile Asp Glu Val Met Val Leu Leu Gly Ser Pro Gly Leu Gln Leu 
145                 150                 155                 160 


Phe Asn Val Tyr Pro Trp Leu Gly Ala Leu Leu Gln Leu His Arg Pro 
                165                 170                 175     


Val Leu Arg Lys Ile Glu Glu Val Arg Ala Ile Leu Arg Thr Leu Leu 
            180                 185                 190         


Glu Ala Arg Arg Pro His Val Cys Pro Gly Asp Pro Val Cys Ser Tyr 
        195                 200                 205             


Val Asp Ala Leu Ile Gln Gln Gly Gln Gly Asp Asp Pro Glu Gly Leu 
    210                 215                 220                 


Phe Ala Glu Ala Asn Ala Val Ala Cys Thr Leu Asp Met Val Met Ala 
225                 230                 235                 240 


Gly Thr Glu Thr Thr Ser Ala Thr Leu Gln Trp Ala Ala Leu Leu Met 
                245                 250                 255     


Gly Arg His Pro Asp Val Gln Gly Arg Val Gln Glu Glu Leu Asp Arg 
            260                 265                 270         


Val Leu Gly Pro Gly Arg Thr Pro Arg Leu Glu Asp Gln Gln Ala Leu 
        275                 280                 285             


Pro Tyr Thr Ser Ala Val Leu His Glu Val Gln Arg Phe Ile Thr Leu 
    290                 295                 300                 


Leu Pro His Val Pro Arg Cys Thr Ala Ala Asp Thr Gln Leu Gly Gly 
305                 310                 315                 320 


Phe Leu Leu Pro Lys Gly Thr Pro Val Ile Pro Leu Leu Thr Ser Val 
                325                 330                 335     


Leu Leu Asp Glu Thr Gln Trp Gln Thr Pro Gly Gln Phe Asn Pro Gly 
            340                 345                 350         


His Phe Leu Asp Ala Asn Gly His Phe Val Lys Arg Glu Ala Phe Leu 
        355                 360                 365             


Pro Phe Ser Ala Gly Gln Gln Pro Ser Gly Pro Gly Trp Gly Gly Thr 
    370                 375                 380                 


Ser Arg Ala Pro Gly Val Gly Arg Pro Gln Leu Arg Leu Pro Pro Leu 
385                 390                 395                 400 


His Pro Pro Pro Asp Leu Arg Phe 
                405             


<210>  3907
<211>  96
<212>  PRT
<213>  Homo Sapiens

<400>  3907

Met Ser Pro Gly Leu Leu Leu Leu Gly Ser Ala Val Leu Leu Ala Phe 
1               5                   10                  15      


Gly Leu Cys Cys Thr Phe Val His Arg Ala Arg Ser Arg Tyr Glu His 
            20                  25                  30          


Ile Pro Gly Pro Pro Arg Pro Ser Phe Leu Leu Gly His Leu Pro Cys 
        35                  40                  45              


Phe Trp Lys Lys Asp Glu Val Gly Gly Arg Val Leu Gln Asp Val Phe 
    50                  55                  60                  


Leu Asp Trp Ala Lys Lys Tyr Gly Pro Val Val Arg Val Asn Val Phe 
65                  70                  75                  80  


His Lys Thr Ser Val Ile Val Thr Ser Pro Glu Ser Val Lys Phe His 
                85                  90                  95      


<210>  3908
<211>  500
<212>  PRT
<213>  Homo Sapiens

<400>  3908

Met Ser Pro Gly Leu Leu Leu Leu Gly Ser Ala Val Leu Leu Ala Phe 
1               5                   10                  15      


Gly Leu Cys Cys Thr Phe Val His Arg Ala Arg Ser Arg Tyr Glu His 
            20                  25                  30          


Ile Pro Gly Pro Pro Arg Pro Ser Phe Leu Leu Gly His Leu Pro Cys 
        35                  40                  45              


Phe Trp Lys Lys Asp Glu Val Gly Gly Arg Val Leu Gln Asp Val Phe 
    50                  55                  60                  


Leu Asp Trp Ala Lys Lys Tyr Gly Pro Val Val Arg Val Asn Val Phe 
65                  70                  75                  80  


His Lys Thr Ser Val Ile Val Thr Ser Pro Glu Ser Val Lys Lys Phe 
                85                  90                  95      


Leu Met Ser Thr Lys Tyr Asn Lys Asp Ser Lys Met Tyr Arg Ala Leu 
            100                 105                 110         


Gln Thr Val Phe Gly Glu Arg Leu Phe Gly Gln Gly Leu Val Ser Glu 
        115                 120                 125             


Cys Asn Tyr Glu Arg Trp His Lys Gln Arg Arg Val Ile Asp Leu Ala 
    130                 135                 140                 


Phe Ser Arg Ser Ser Leu Val Ser Leu Met Glu Thr Phe Asn Glu Lys 
145                 150                 155                 160 


Ala Glu Gln Leu Val Glu Ile Leu Glu Ala Lys Ala Asp Gly Gln Thr 
                165                 170                 175     


Pro Val Ser Met Gln Asp Met Leu Thr Tyr Thr Ala Met Asp Ile Leu 
            180                 185                 190         


Ala Lys Ala Ala Phe Gly Met Glu Thr Ser Met Leu Leu Gly Ala Gln 
        195                 200                 205             


Lys Pro Leu Ser Gln Ala Val Lys Leu Met Leu Glu Gly Ile Thr Ala 
    210                 215                 220                 


Ser Arg Asn Thr Leu Ala Lys Phe Leu Pro Gly Lys Arg Lys Gln Leu 
225                 230                 235                 240 


Arg Glu Val Arg Glu Ser Ile Arg Phe Leu Arg Gln Val Gly Arg Asp 
                245                 250                 255     


Trp Val Gln Arg Arg Arg Glu Ala Leu Lys Arg Gly Glu Glu Val Pro 
            260                 265                 270         


Ala Asp Ile Leu Thr Gln Ile Leu Lys Ala Glu Glu Gly Ala Gln Asp 
        275                 280                 285             


Asp Glu Gly Leu Leu Asp Asn Phe Val Thr Phe Phe Ile Ala Gly His 
    290                 295                 300                 


Glu Thr Ser Ala Asn His Leu Ala Phe Thr Val Met Glu Leu Ser Arg 
305                 310                 315                 320 


Gln Pro Glu Ile Val Ala Arg Leu Gln Ala Glu Val Asp Glu Val Ile 
                325                 330                 335     


Gly Ser Lys Arg Tyr Leu Asp Phe Glu Asp Leu Gly Arg Leu Gln Tyr 
            340                 345                 350         


Leu Ser Gln Val Leu Lys Glu Ser Leu Arg Leu Tyr Pro Pro Ala Trp 
        355                 360                 365             


Gly Thr Phe Arg Leu Leu Glu Glu Glu Thr Leu Ile Asp Gly Val Arg 
    370                 375                 380                 


Val Pro Gly Asn Thr Pro Leu Leu Phe Ser Thr Tyr Val Met Gly Arg 
385                 390                 395                 400 


Met Asp Thr Tyr Phe Glu Asp Pro Leu Thr Phe Asn Pro Asp Arg Phe 
                405                 410                 415     


Gly Pro Gly Ala Pro Lys Pro Arg Phe Thr Tyr Phe Pro Phe Ser Leu 
            420                 425                 430         


Gly His Arg Ser Cys Ile Gly Gln Gln Phe Ala Gln Met Glu Val Lys 
        435                 440                 445             


Val Val Met Ala Lys Leu Leu Gln Arg Leu Glu Phe Arg Leu Val Pro 
    450                 455                 460                 


Gly Gln Arg Phe Gly Leu Gln Glu Gln Ala Thr Leu Lys Pro Leu Asp 
465                 470                 475                 480 


Pro Val Leu Cys Thr Leu Arg Pro Arg Gly Trp Gln Pro Ala Pro Pro 
                485                 490                 495     


Pro Pro Pro Cys 
            500 


<210>  3909
<211>  403
<212>  PRT
<213>  Homo Sapiens

<400>  3909

Met Ser Thr Lys Tyr Asn Lys Asp Ser Lys Met Tyr Arg Ala Leu Gln 
1               5                   10                  15      


Thr Val Phe Gly Glu Arg Leu Phe Gly Gln Gly Leu Val Ser Glu Cys 
            20                  25                  30          


Asn Tyr Glu Arg Trp His Lys Gln Arg Arg Val Ile Asp Leu Ala Phe 
        35                  40                  45              


Ser Arg Ser Ser Leu Val Ser Leu Met Glu Thr Phe Asn Glu Lys Ala 
    50                  55                  60                  


Glu Gln Leu Val Glu Ile Leu Glu Ala Lys Ala Asp Gly Gln Thr Pro 
65                  70                  75                  80  


Val Ser Met Gln Asp Met Leu Thr Tyr Thr Ala Met Asp Ile Leu Ala 
                85                  90                  95      


Lys Ala Ala Phe Gly Met Glu Thr Ser Met Leu Leu Gly Ala Gln Lys 
            100                 105                 110         


Pro Leu Ser Gln Ala Val Lys Leu Met Leu Glu Gly Ile Thr Ala Ser 
        115                 120                 125             


Arg Asn Thr Leu Ala Lys Phe Leu Pro Gly Lys Arg Lys Gln Leu Arg 
    130                 135                 140                 


Glu Val Arg Glu Ser Ile Arg Phe Leu Arg Gln Val Gly Arg Asp Trp 
145                 150                 155                 160 


Val Gln Arg Arg Arg Glu Ala Leu Lys Arg Gly Glu Glu Val Pro Ala 
                165                 170                 175     


Asp Ile Leu Thr Gln Ile Leu Lys Ala Glu Glu Gly Ala Gln Asp Asp 
            180                 185                 190         


Glu Gly Leu Leu Asp Asn Phe Val Thr Phe Phe Ile Ala Gly His Glu 
        195                 200                 205             


Thr Ser Ala Asn His Leu Ala Phe Thr Val Met Glu Leu Ser Arg Gln 
    210                 215                 220                 


Pro Glu Ile Val Ala Arg Leu Gln Ala Glu Val Asp Glu Val Ile Gly 
225                 230                 235                 240 


Ser Lys Arg Tyr Leu Asp Phe Glu Asp Leu Gly Arg Leu Gln Tyr Leu 
                245                 250                 255     


Ser Gln Val Leu Lys Glu Ser Leu Arg Leu Tyr Pro Pro Ala Trp Gly 
            260                 265                 270         


Thr Phe Arg Leu Leu Glu Glu Glu Thr Leu Ile Asp Gly Val Arg Val 
        275                 280                 285             


Pro Gly Asn Thr Pro Leu Leu Phe Ser Thr Tyr Val Met Gly Arg Met 
    290                 295                 300                 


Asp Thr Tyr Phe Glu Asp Pro Leu Thr Phe Asn Pro Asp Arg Phe Gly 
305                 310                 315                 320 


Pro Gly Ala Pro Lys Pro Arg Phe Thr Tyr Phe Pro Phe Ser Leu Gly 
                325                 330                 335     


His Arg Ser Cys Ile Gly Gln Gln Phe Ala Gln Met Glu Val Lys Val 
            340                 345                 350         


Val Met Ala Lys Leu Leu Gln Arg Leu Glu Phe Arg Leu Val Pro Gly 
        355                 360                 365             


Gln Arg Phe Gly Leu Gln Glu Gln Ala Thr Leu Lys Pro Leu Asp Pro 
    370                 375                 380                 


Val Leu Cys Thr Leu Arg Pro Arg Gly Trp Gln Pro Ala Pro Pro Pro 
385                 390                 395                 400 


Pro Pro Cys 
            


<210>  3910
<211>  164
<212>  PRT
<213>  Homo Sapiens

<400>  3910

Arg Phe Leu Arg Gln Val Gly Arg Asp Trp Val Gln Arg Arg Arg Glu 
1               5                   10                  15      


Ala Leu Lys Arg Gly Glu Glu Val Pro Ala Asp Ile Leu Thr Gln Ile 
            20                  25                  30          


Leu Lys Ala Glu Glu Gly Ala Gln Asp Asp Glu Gly Leu Leu Asp Asn 
        35                  40                  45              


Phe Val Thr Phe Phe Ile Ala Gly His Glu Thr Ser Ala Asn His Leu 
    50                  55                  60                  


Ala Phe Thr Val Met Glu Leu Ser Arg Gln Pro Glu Ile Val Ala Arg 
65                  70                  75                  80  


Leu Gln Ala Glu Val Asp Glu Val Ile Gly Ser Lys Arg Tyr Leu Asp 
                85                  90                  95      


Phe Glu Asp Leu Gly Arg Leu Gln Tyr Leu Ser Gln Val Leu Lys Glu 
            100                 105                 110         


Ser Leu Arg Leu Tyr Pro Pro Ala Trp Gly Thr Phe Arg Leu Leu Glu 
        115                 120                 125             


Glu Glu Thr Leu Ile Asp Gly Val Arg Val Pro Gly Asn Thr Pro Leu 
    130                 135                 140                 


Leu Glu Gln Cys Ala Ser Gln Leu Leu Gly His Leu Pro Arg Ser Glu 
145                 150                 155                 160 


Arg Ala Gly Leu 
                


<210>  3911
<211>  51
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3911

Xaa Pro Ala Arg Glu Glu Glu Ala Ala Pro Gly Gly Pro Gly Glu His 
1               5                   10                  15      


Ser Leu Pro Ala Pro Gly Gly Gln Gly Leu Gly Pro Ala Pro Pro Gly 
            20                  25                  30          


Ser Pro Glu Glu Gly Arg Gly Gly Ser Cys Arg His Pro His Thr Asp 
        35                  40                  45              


Ser Glu Ser 
    50      


<210>  3912
<211>  199
<212>  PRT
<213>  Homo Sapiens

<400>  3912

Met Phe Glu Gly His Asp Thr Thr Ala Ser Gly Leu Ser Trp Val Leu 
1               5                   10                  15      


Tyr His Leu Ala Lys His Pro Glu Tyr Gln Glu Gln Cys Arg Gln Glu 
            20                  25                  30          


Val Gln Glu Leu Leu Lys Asp Arg Glu Pro Ile Glu Ile Glu Trp Asp 
        35                  40                  45              


Asp Leu Ala Gln Leu Pro Phe Leu Thr Met Cys Ile Lys Glu Ser Leu 
    50                  55                  60                  


Arg Leu His Pro Pro Val Pro Val Ile Ser Arg Cys Cys Thr Gln Asp 
65                  70                  75                  80  


Phe Val Leu Pro Asp Gly Arg Val Ile Pro Lys Gly Ile Val Cys Leu 
                85                  90                  95      


Ile Asn Ile Ile Gly Ile His Tyr Asn Pro Thr Val Trp Pro Asp Pro 
            100                 105                 110         


Glu Val Tyr Asp Pro Phe Arg Phe Asp Gln Glu Asn Ile Lys Glu Arg 
        115                 120                 125             


Ser Pro Leu Ala Phe Ile Pro Phe Ser Ala Gly Pro Arg Asn Cys Ile 
    130                 135                 140                 


Gly Gln Ala Phe Ala Met Ala Glu Met Lys Val Val Leu Ala Leu Thr 
145                 150                 155                 160 


Leu Leu His Phe Arg Ile Leu Pro Thr His Thr Glu Pro Arg Arg Lys 
                165                 170                 175     


Pro Glu Leu Ile Leu Arg Ala Glu Gly Gly Leu Trp Leu Arg Val Glu 
            180                 185                 190         


Pro Leu Gly Ala Asn Ser Gln 
        195                 


<210>  3913
<211>  524
<212>  PRT
<213>  Homo Sapiens

<400>  3913

Met Pro Gln Leu Ser Leu Ser Trp Leu Gly Leu Gly Pro Val Ala Ala 
1               5                   10                  15      


Ser Pro Trp Leu Leu Leu Leu Leu Val Gly Gly Ser Trp Leu Leu Ala 
            20                  25                  30          


Arg Val Leu Ala Trp Thr Tyr Thr Phe Tyr Asp Asn Cys Arg Arg Leu 
        35                  40                  45              


Gln Cys Phe Pro Gln Pro Pro Lys Gln Asn Trp Phe Trp Gly His Gln 
    50                  55                  60                  


Gly Leu Val Thr Pro Thr Glu Glu Gly Met Lys Thr Leu Thr Gln Leu 
65                  70                  75                  80  


Val Thr Thr Tyr Pro Gln Gly Phe Lys Leu Trp Leu Gly Pro Thr Phe 
                85                  90                  95      


Pro Leu Leu Ile Leu Cys His Pro Asp Ile Ile Arg Pro Ile Thr Ser 
            100                 105                 110         


Ala Ser Ala Ala Val Ala Pro Lys Asp Met Ile Phe Tyr Gly Phe Leu 
        115                 120                 125             


Lys Pro Trp Leu Gly Asp Gly Leu Leu Leu Ser Gly Gly Asp Lys Trp 
    130                 135                 140                 


Ser Arg His Arg Arg Met Leu Thr Pro Ala Phe His Phe Asn Ile Leu 
145                 150                 155                 160 


Lys Pro Tyr Met Lys Ile Phe Asn Lys Ser Val Asn Ile Met His Asp 
                165                 170                 175     


Lys Trp Gln Arg Leu Ala Ser Glu Gly Ser Ala Arg Leu Asp Met Phe 
            180                 185                 190         


Glu His Ile Ser Leu Met Thr Leu Asp Ser Leu Gln Lys Cys Val Phe 
        195                 200                 205             


Ser Phe Glu Ser Asn Cys Gln Glu Lys Pro Ser Glu Tyr Ile Ala Ala 
    210                 215                 220                 


Ile Leu Glu Leu Ser Ala Phe Val Glu Lys Arg Asn Gln Gln Ile Leu 
225                 230                 235                 240 


Leu His Thr Asp Phe Leu Tyr Tyr Leu Thr Pro Asp Gly Gln Arg Phe 
                245                 250                 255     


Arg Arg Ala Cys His Leu Val His Asp Phe Thr Asp Ala Val Ile Gln 
            260                 265                 270         


Glu Arg Arg Cys Thr Leu Pro Thr Gln Gly Ile Asp Asp Phe Leu Lys 
        275                 280                 285             


Asn Lys Ala Lys Ser Lys Thr Leu Asp Phe Ile Asp Val Leu Leu Leu 
    290                 295                 300                 


Ser Lys Asp Glu Asp Gly Lys Glu Leu Ser Asp Glu Asp Ile Arg Ala 
305                 310                 315                 320 


Glu Ala Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ser Gly 
                325                 330                 335     


Leu Ser Trp Val Leu Tyr His Leu Ala Lys His Pro Glu Tyr Gln Glu 
            340                 345                 350         


Gln Cys Arg Gln Glu Val Gln Glu Leu Leu Lys Asp Arg Glu Pro Ile 
        355                 360                 365             


Glu Ile Glu Trp Asp Asp Leu Ala Gln Leu Pro Phe Leu Thr Met Cys 
    370                 375                 380                 


Ile Lys Glu Ser Leu Arg Leu His Pro Pro Val Pro Val Ile Ser Arg 
385                 390                 395                 400 


Cys Cys Thr Gln Asp Phe Val Leu Pro Asp Gly Arg Val Ile Pro Lys 
                405                 410                 415     


Gly Ile Val Cys Leu Ile Asn Ile Ile Gly Ile His Tyr Asn Pro Thr 
            420                 425                 430         


Val Trp Pro Asp Pro Glu Val Tyr Asp Pro Phe Arg Phe Asp Gln Glu 
        435                 440                 445             


Asn Ile Lys Glu Arg Ser Pro Leu Ala Phe Ile Pro Phe Ser Ala Gly 
    450                 455                 460                 


Pro Arg Asn Cys Ile Gly Gln Ala Phe Ala Met Ala Glu Met Lys Val 
465                 470                 475                 480 


Val Leu Ala Leu Thr Leu Leu His Phe Arg Ile Leu Pro Thr His Thr 
                485                 490                 495     


Glu Pro Arg Arg Lys Pro Glu Leu Ile Leu Arg Ala Glu Gly Gly Leu 
            500                 505                 510         


Trp Leu Arg Val Glu Pro Leu Gly Ala Asn Ser Gln 
        515                 520                 


<210>  3914
<211>  454
<212>  PRT
<213>  Homo Sapiens

<400>  3914

Met Pro Gln Leu Ser Leu Ser Trp Leu Gly Leu Gly Pro Val Ala Ala 
1               5                   10                  15      


Ser Pro Trp Leu Leu Leu Leu Leu Val Gly Gly Ser Trp Leu Leu Ala 
            20                  25                  30          


Arg Val Leu Ala Trp Thr Tyr Thr Phe Tyr Asp Asn Cys Arg Arg Leu 
        35                  40                  45              


Gln Cys Phe Pro Gln Pro Pro Lys Gln Asn Trp Phe Trp Gly His Gln 
    50                  55                  60                  


Gly Leu Val Thr Pro Thr Glu Glu Gly Met Lys Thr Leu Thr Gln Leu 
65                  70                  75                  80  


Val Thr Thr Tyr Pro Gln Gly Phe Lys Leu Trp Leu Gly Pro Thr Phe 
                85                  90                  95      


Pro Leu Leu Ile Leu Cys His Pro Asp Ile Ile Arg Pro Ile Thr Ser 
            100                 105                 110         


Ala Ser Ala Ala Val Ala Pro Lys Asp Met Ile Phe Tyr Gly Phe Leu 
        115                 120                 125             


Lys Pro Trp Leu Gly Asp Gly Leu Leu Leu Ser Gly Gly Asp Lys Trp 
    130                 135                 140                 


Ser Arg His Arg Arg Met Leu Thr Pro Ala Phe His Phe Asn Ile Leu 
145                 150                 155                 160 


Lys Pro Tyr Met Lys Ile Phe Asn Lys Ser Val Asn Ile Met His Asp 
                165                 170                 175     


Lys Trp Gln Arg Leu Ala Ser Glu Gly Ser Ala Arg Leu Asp Met Phe 
            180                 185                 190         


Glu His Ile Ser Leu Met Thr Leu Asp Ser Leu Gln Lys Cys Val Phe 
        195                 200                 205             


Ser Phe Glu Ser Asn Cys Gln Glu Lys Pro Ser Glu Tyr Ile Ala Ala 
    210                 215                 220                 


Ile Leu Glu Leu Ser Ala Phe Val Glu Lys Arg Asn Gln Gln Ile Leu 
225                 230                 235                 240 


Leu His Thr Asp Phe Leu Tyr Tyr Leu Thr Pro Asp Gly Gln Arg Phe 
                245                 250                 255     


Arg Arg Ala Cys His Leu Val His Asp Phe Thr Asp Ala Val Ile Gln 
            260                 265                 270         


Glu Arg Arg Cys Thr Leu Pro Thr Gln Gly Ile Asp Asp Phe Leu Lys 
        275                 280                 285             


Asn Lys Ala Lys Ser Lys Thr Leu Asp Phe Ile Asp Val Leu Leu Leu 
    290                 295                 300                 


Ser Lys Asp Glu Asp Gly Lys Glu Leu Ser Asp Glu Asp Ile Arg Ala 
305                 310                 315                 320 


Glu Ala Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ser Gly 
                325                 330                 335     


Leu Ser Trp Val Leu Tyr His Leu Ala Lys His Pro Glu Tyr Gln Glu 
            340                 345                 350         


Gln Cys Arg Gln Glu Val Gln Glu Leu Leu Lys Asp Arg Glu Pro Ile 
        355                 360                 365             


Glu Ile Glu Trp Asp Asp Leu Ala Gln Leu Pro Phe Leu Thr Met Cys 
    370                 375                 380                 


Ile Lys Glu Ser Leu Arg Leu His Pro Pro Val Pro Val Ile Ser Arg 
385                 390                 395                 400 


Cys Cys Thr Gln Asp Phe Val Leu Pro Asp Gly Arg Val Ile Pro Lys 
                405                 410                 415     


Gly Leu Arg Pro Leu Pro Phe Arg Pro Arg Glu His Gln Gly Glu Val 
            420                 425                 430         


Thr Ser Gly Phe Tyr Ser Leu Leu Gly Arg Ala Gln Lys Leu His Arg 
        435                 440                 445             


Ala Gly Val Arg His Gly 
    450                 


<210>  3915
<211>  524
<212>  PRT
<213>  Homo Sapiens

<400>  3915

Met Pro Gln Leu Ser Leu Ser Trp Leu Gly Leu Gly Pro Val Ala Ala 
1               5                   10                  15      


Ser Pro Trp Leu Leu Leu Leu Leu Val Gly Gly Ser Trp Leu Leu Ala 
            20                  25                  30          


Arg Val Leu Ala Trp Thr Tyr Thr Phe Tyr Asp Asn Cys Arg Arg Leu 
        35                  40                  45              


Gln Cys Phe Pro Gln Pro Pro Lys Gln Asn Trp Phe Trp Gly His Gln 
    50                  55                  60                  


Gly Leu Val Thr Pro Thr Glu Glu Gly Met Lys Thr Leu Thr Gln Leu 
65                  70                  75                  80  


Val Thr Thr Tyr Pro Gln Gly Phe Lys Leu Trp Leu Gly Pro Thr Phe 
                85                  90                  95      


Pro Leu Leu Ile Leu Cys His Pro Asp Ile Ile Arg Pro Ile Thr Ser 
            100                 105                 110         


Ala Ser Ala Ala Val Ala Pro Lys Asp Met Ile Phe Tyr Gly Phe Leu 
        115                 120                 125             


Lys Pro Trp Leu Gly Asp Gly Leu Leu Leu Ser Gly Gly Asp Lys Trp 
    130                 135                 140                 


Ser Arg His Arg Arg Met Leu Thr Pro Ala Phe His Phe Asn Ile Leu 
145                 150                 155                 160 


Lys Pro Tyr Met Lys Ile Phe Asn Lys Ser Val Asn Ile Met His Asp 
                165                 170                 175     


Lys Trp Gln Arg Leu Ala Ser Glu Gly Ser Ala Arg Leu Asp Met Phe 
            180                 185                 190         


Glu His Ile Ser Leu Met Thr Leu Asp Ser Leu Gln Lys Cys Val Phe 
        195                 200                 205             


Ser Phe Glu Ser Asn Cys Gln Glu Lys Pro Ser Glu Tyr Ile Ala Ala 
    210                 215                 220                 


Ile Leu Glu Leu Ser Ala Phe Val Glu Lys Arg Asn Gln Gln Ile Leu 
225                 230                 235                 240 


Leu His Thr Asp Phe Leu Tyr Tyr Leu Thr Pro Asp Gly Gln Arg Phe 
                245                 250                 255     


Arg Arg Ala Cys His Leu Val His Asp Phe Thr Asp Ala Val Ile Gln 
            260                 265                 270         


Glu Arg Arg Cys Thr Leu Pro Thr Gln Gly Ile Asp Asp Phe Leu Lys 
        275                 280                 285             


Asn Lys Ala Lys Ser Lys Thr Leu Asp Phe Ile Asp Val Leu Leu Leu 
    290                 295                 300                 


Ser Lys Asp Glu Asp Gly Lys Glu Leu Ser Asp Glu Asp Ile Arg Ala 
305                 310                 315                 320 


Glu Ala Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ser Gly 
                325                 330                 335     


Leu Ser Trp Val Leu Tyr His Leu Ala Lys His Pro Glu Tyr Gln Glu 
            340                 345                 350         


Gln Cys Arg Gln Glu Val Gln Glu Leu Leu Lys Asp Arg Glu Pro Ile 
        355                 360                 365             


Glu Ile Glu Trp Asp Asp Leu Ala Gln Leu Pro Phe Leu Thr Met Cys 
    370                 375                 380                 


Ile Lys Glu Ser Leu Arg Leu His Pro Pro Val Pro Val Ile Ser Arg 
385                 390                 395                 400 


Cys Cys Thr Gln Asp Phe Val Leu Pro Asp Gly Arg Val Ile Pro Lys 
                405                 410                 415     


Gly Ile Val Cys Leu Ile Asn Ile Ile Gly Ile His Tyr Asn Pro Thr 
            420                 425                 430         


Val Trp Pro Asp Pro Glu Val Tyr Asp Pro Phe Arg Phe Asp Gln Glu 
        435                 440                 445             


Asn Ile Lys Glu Arg Ser Pro Leu Ala Phe Ile Pro Phe Ser Ala Gly 
    450                 455                 460                 


Pro Arg Asn Cys Ile Gly Gln Ala Phe Ala Met Ala Glu Met Lys Val 
465                 470                 475                 480 


Val Leu Ala Leu Thr Leu Leu His Phe Arg Ile Leu Pro Thr His Thr 
                485                 490                 495     


Glu Pro Arg Arg Lys Pro Glu Leu Ile Leu Arg Ala Glu Gly Gly Leu 
            500                 505                 510         


Trp Leu Arg Val Glu Pro Leu Gly Ala Asn Ser Gln 
        515                 520                 


<210>  3916
<211>  454
<212>  PRT
<213>  Homo Sapiens

<400>  3916

Met Pro Gln Leu Ser Leu Ser Trp Leu Gly Leu Gly Pro Val Ala Ala 
1               5                   10                  15      


Ser Pro Trp Leu Leu Leu Leu Leu Val Gly Gly Ser Trp Leu Leu Ala 
            20                  25                  30          


Arg Val Leu Ala Trp Thr Tyr Thr Phe Tyr Asp Asn Cys Arg Arg Leu 
        35                  40                  45              


Gln Cys Phe Pro Gln Pro Pro Lys Gln Asn Trp Phe Trp Gly His Gln 
    50                  55                  60                  


Gly Leu Val Thr Pro Thr Glu Glu Gly Met Lys Thr Leu Thr Gln Leu 
65                  70                  75                  80  


Val Thr Thr Tyr Pro Gln Gly Phe Lys Leu Trp Leu Gly Pro Thr Phe 
                85                  90                  95      


Pro Leu Leu Ile Leu Cys His Pro Asp Ile Ile Arg Pro Ile Thr Ser 
            100                 105                 110         


Ala Ser Ala Ala Val Ala Pro Lys Asp Met Ile Phe Tyr Gly Phe Leu 
        115                 120                 125             


Lys Pro Trp Leu Gly Asp Gly Leu Leu Leu Ser Gly Gly Asp Lys Trp 
    130                 135                 140                 


Ser Arg His Arg Arg Met Leu Thr Pro Ala Phe His Phe Asn Ile Leu 
145                 150                 155                 160 


Lys Pro Tyr Met Lys Ile Phe Asn Lys Ser Val Asn Ile Met His Asp 
                165                 170                 175     


Lys Trp Gln Arg Leu Ala Ser Glu Gly Ser Ala Arg Leu Asp Met Phe 
            180                 185                 190         


Glu His Ile Ser Leu Met Thr Leu Asp Ser Leu Gln Lys Cys Val Phe 
        195                 200                 205             


Ser Phe Glu Ser Asn Cys Gln Glu Lys Pro Ser Glu Tyr Ile Ala Ala 
    210                 215                 220                 


Ile Leu Glu Leu Ser Ala Phe Val Glu Lys Arg Asn Gln Gln Ile Leu 
225                 230                 235                 240 


Leu His Thr Asp Phe Leu Tyr Tyr Leu Thr Pro Asp Gly Gln Arg Phe 
                245                 250                 255     


Arg Arg Ala Cys His Leu Val His Asp Phe Thr Asp Ala Val Ile Gln 
            260                 265                 270         


Glu Arg Arg Cys Thr Leu Pro Thr Gln Gly Ile Asp Asp Phe Leu Lys 
        275                 280                 285             


Asn Lys Ala Lys Ser Lys Thr Leu Asp Phe Ile Asp Val Leu Leu Leu 
    290                 295                 300                 


Ser Lys Asp Glu Asp Gly Lys Glu Leu Ser Asp Glu Asp Ile Arg Ala 
305                 310                 315                 320 


Glu Ala Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ser Gly 
                325                 330                 335     


Leu Ser Trp Val Leu Tyr His Leu Ala Lys His Pro Glu Tyr Gln Glu 
            340                 345                 350         


Gln Cys Arg Gln Glu Val Gln Glu Leu Leu Lys Asp Arg Glu Pro Ile 
        355                 360                 365             


Glu Ile Glu Trp Asp Asp Leu Ala Gln Leu Pro Phe Leu Thr Met Cys 
    370                 375                 380                 


Ile Lys Glu Ser Leu Arg Leu His Pro Pro Val Pro Val Ile Ser Arg 
385                 390                 395                 400 


Cys Cys Thr Gln Asp Phe Val Leu Pro Asp Gly Arg Val Ile Pro Lys 
                405                 410                 415     


Gly Leu Arg Pro Leu Pro Phe Arg Pro Arg Glu His Gln Gly Glu Val 
            420                 425                 430         


Thr Ser Gly Phe Tyr Ser Leu Leu Gly Arg Ala Gln Lys Leu His Arg 
        435                 440                 445             


Ala Gly Val Arg His Gly 
    450                 


<210>  3917
<211>  520
<212>  PRT
<213>  Homo Sapiens

<400>  3917

Met Ser Gln Leu Ser Leu Ser Trp Leu Gly Leu Trp Pro Val Ala Ala 
1               5                   10                  15      


Ser Pro Trp Leu Leu Leu Leu Leu Val Gly Ala Ser Trp Leu Leu Ala 
            20                  25                  30          


His Val Leu Ala Trp Thr Tyr Ala Phe Tyr Asp Asn Cys Arg Arg Leu 
        35                  40                  45              


Arg Cys Phe Pro Gln Pro Pro Arg Arg Asn Trp Phe Trp Gly His Gln 
    50                  55                  60                  


Gly Met Ile His Ser Ser Glu Glu Gly Leu Leu Tyr Thr Gln Ser Leu 
65                  70                  75                  80  


Ala Cys Thr Phe Gly Asp Met Gly Cys Trp Trp Val Gly Pro Trp Gln 
                85                  90                  95      


Ala Val Ile His Ile Phe Leu Pro Thr Cys Ile Lys Pro Val Leu Phe 
            100                 105                 110         


Ala Pro Ala Ala Ile Ala Pro Lys Asp Lys Phe Phe Tyr Ser Phe Leu 
        115                 120                 125             


Glu Pro Trp Leu Gly Asp Gly Leu Leu Leu Ser Ala Gly Asp Lys Trp 
    130                 135                 140                 


Ser Arg His Arg Arg Met Leu Thr Pro Ala Phe His Phe Asn Ile Leu 
145                 150                 155                 160 


Lys Pro Tyr Met Lys Ile Phe Asn Glu Ser Val Asn Ile Met His Ala 
                165                 170                 175     


Lys Trp Gln Leu Leu Ala Ser Glu Gly Ser Ala Cys Leu Asp Met Phe 
            180                 185                 190         


Glu His Ile Ser Leu Met Thr Leu Asp Ser Leu Gln Lys Cys Val Phe 
        195                 200                 205             


Ser Phe Asp Ser His Cys Gln Glu Lys Pro Ser Glu Tyr Ile Ala Ala 
    210                 215                 220                 


Ile Leu Glu Leu Ser Ala Leu Val Ser Lys Arg His His Glu Ile Leu 
225                 230                 235                 240 


Leu His Ile Asp Phe Leu Tyr Tyr Leu Thr Pro Asp Gly Gln Arg Phe 
                245                 250                 255     


Arg Arg Ala Cys Arg Leu Val His Asp Phe Thr Asp Ala Val Ile Gln 
            260                 265                 270         


Glu Arg Arg Arg Thr Leu Pro Ser Gln Gly Val Asp Asp Phe Leu Gln 
        275                 280                 285             


Ala Lys Ala Lys Ser Lys Thr Leu Asp Phe Ile Asp Val Leu Leu Leu 
    290                 295                 300                 


Ser Lys Asp Glu Asp Gly Lys Lys Leu Ser Asp Glu Asp Ile Arg Ala 
305                 310                 315                 320 


Glu Ala Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ser Gly 
                325                 330                 335     


Leu Ser Trp Val Leu Tyr His Leu Ala Lys His Pro Glu Tyr Gln Glu 
            340                 345                 350         


Arg Cys Arg Gln Glu Val Gln Glu Leu Leu Lys Asp Arg Glu Pro Lys 
        355                 360                 365             


Glu Ile Glu Trp Asp Asp Leu Ala His Leu Pro Phe Leu Thr Met Cys 
    370                 375                 380                 


Met Lys Glu Ser Leu Arg Leu His Pro Pro Val Pro Val Ile Ser Arg 
385                 390                 395                 400 


His Val Thr Gln Asp Ile Val Leu Pro Asp Gly Arg Val Ile Pro Lys 
                405                 410                 415     


Gly Ile Ile Cys Leu Ile Ser Val Phe Gly Thr His His Asn Pro Ala 
            420                 425                 430         


Val Trp Pro Asp Pro Glu Val Tyr Asp Pro Phe Arg Phe Asp Pro Glu 
        435                 440                 445             


Asn Ile Lys Glu Arg Ser Pro Leu Ala Phe Ile Pro Phe Ser Ala Gly 
    450                 455                 460                 


Pro Arg Asn Cys Ile Gly Gln Thr Phe Ala Met Ala Glu Met Lys Val 
465                 470                 475                 480 


Val Leu Ala Leu Thr Leu Leu Arg Phe Arg Val Leu Pro Asp His Thr 
                485                 490                 495     


Glu Pro Arg Arg Lys Pro Glu Leu Val Leu Arg Ala Glu Gly Gly Leu 
            500                 505                 510         


Trp Leu Arg Val Glu Pro Leu Ser 
        515                 520 


<210>  3918
<211>  89
<212>  PRT
<213>  Homo Sapiens

<400>  3918

Met Ser Gln Leu Ser Leu Ser Trp Leu Gly Leu Trp Pro Val Ala Ala 
1               5                   10                  15      


Ser Pro Trp Leu Leu Leu Leu Leu Val Gly Ala Ser Trp Leu Leu Ala 
            20                  25                  30          


His Val Leu Ala Trp Thr Tyr Ala Phe Tyr Asp Asn Cys Arg Arg Leu 
        35                  40                  45              


Arg Cys Phe Pro Gln Pro Pro Arg Arg Asn Trp Phe Trp Gly His Gln 
    50                  55                  60                  


Gly Met Leu Pro Leu His Gln Arg Thr Ser Ser Ser Thr Ala Ser Trp 
65                  70                  75                  80  


Ser Pro Gly Trp Gly Met Gly Ser Cys 
                85                  


<210>  3919
<211>  154
<212>  PRT
<213>  Homo Sapiens

<400>  3919

Met Ser Gln Leu Ser Leu Ser Trp Leu Gly Leu Trp Pro Val Ala Ala 
1               5                   10                  15      


Ser Pro Trp Leu Leu Leu Leu Leu Val Gly Ala Ser Trp Leu Leu Ala 
            20                  25                  30          


His Val Leu Ala Trp Thr Tyr Ala Phe Tyr Asp Asn Cys Arg Arg Leu 
        35                  40                  45              


Arg Cys Phe Pro Gln Pro Pro Arg Arg Asn Trp Phe Trp Gly His Gln 
    50                  55                  60                  


Gly Met Val Asn Pro Thr Glu Glu Gly Met Arg Val Leu Thr Gln Leu 
65                  70                  75                  80  


Val Ala Thr Tyr Pro Gln Gly Phe Lys Val Trp Met Gly Pro Ile Ser 
                85                  90                  95      


Pro Leu Leu Ser Leu Cys His Pro Asp Ile Ile Arg Ser Val Ile Asn 
            100                 105                 110         


Ala Ser Ala Ala Ile Ala Pro Lys Asp Lys Phe Phe Tyr Ser Phe Leu 
        115                 120                 125             


Glu Pro Trp Leu Gly Asp Gly Leu Leu Leu Ser Ala Gly Asp Lys Trp 
    130                 135                 140                 


Ser Arg His Arg Arg Met Leu Thr Pro Ala 
145                 150                 


<210>  3920
<211>  520
<212>  PRT
<213>  Homo Sapiens

<400>  3920

Met Ser Gln Leu Ser Leu Ser Trp Leu Gly Leu Trp Pro Val Ala Ala 
1               5                   10                  15      


Ser Pro Trp Leu Leu Leu Leu Leu Val Gly Ala Ser Trp Leu Leu Ala 
            20                  25                  30          


His Val Leu Ala Trp Thr Tyr Ala Phe Tyr Asp Asn Cys Arg Arg Leu 
        35                  40                  45              


Arg Cys Phe Pro Gln Pro Pro Arg Arg Asn Trp Phe Trp Gly His Gln 
    50                  55                  60                  


Gly Met Val Asn Pro Thr Glu Glu Gly Met Arg Val Leu Thr Gln Leu 
65                  70                  75                  80  


Val Ala Thr Tyr Pro Gln Gly Phe Lys Val Trp Met Gly Pro Ile Ser 
                85                  90                  95      


Pro Leu Leu Ser Leu Cys His Pro Asp Ile Ile Arg Ser Val Ile Asn 
            100                 105                 110         


Ala Ser Ala Ala Ile Ala Pro Lys Asp Lys Phe Phe Tyr Ser Phe Leu 
        115                 120                 125             


Glu Pro Trp Leu Gly Asp Gly Leu Leu Leu Ser Ala Gly Asp Lys Trp 
    130                 135                 140                 


Ser Arg His Arg Arg Met Leu Thr Pro Ala Phe His Phe Asn Ile Leu 
145                 150                 155                 160 


Lys Pro Tyr Met Lys Ile Phe Asn Glu Ser Val Asn Ile Met His Ala 
                165                 170                 175     


Lys Trp Gln Leu Leu Ala Ser Glu Gly Ser Ala Cys Leu Asp Met Phe 
            180                 185                 190         


Glu His Ile Ser Leu Met Thr Leu Asp Ser Leu Gln Lys Cys Val Phe 
        195                 200                 205             


Ser Phe Asp Ser His Cys Gln Glu Lys Pro Ser Glu Tyr Ile Ala Ala 
    210                 215                 220                 


Ile Leu Glu Leu Ser Ala Leu Val Ser Lys Arg His His Glu Ile Leu 
225                 230                 235                 240 


Leu His Ile Asp Phe Leu Tyr Tyr Leu Thr Pro Asp Gly Gln Arg Phe 
                245                 250                 255     


Arg Arg Ala Cys Arg Leu Val His Asp Phe Thr Asp Ala Val Ile Gln 
            260                 265                 270         


Glu Arg Arg Arg Thr Leu Pro Ser Gln Gly Val Asp Asp Phe Leu Gln 
        275                 280                 285             


Ala Lys Ala Lys Ser Lys Thr Leu Asp Phe Ile Asp Val Leu Leu Leu 
    290                 295                 300                 


Ser Lys Asp Glu Asp Gly Lys Lys Leu Ser Asp Glu Asp Ile Arg Ala 
305                 310                 315                 320 


Glu Ala Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ser Gly 
                325                 330                 335     


Leu Ser Trp Val Leu Tyr His Leu Ala Lys His Pro Glu Tyr Gln Glu 
            340                 345                 350         


Arg Cys Arg Gln Glu Val Gln Glu Leu Leu Lys Asp Arg Glu Pro Lys 
        355                 360                 365             


Glu Ile Glu Trp Asp Asp Leu Ala His Leu Pro Phe Leu Thr Met Cys 
    370                 375                 380                 


Met Lys Glu Ser Leu Arg Leu His Pro Pro Val Pro Val Ile Ser Arg 
385                 390                 395                 400 


His Val Thr Gln Asp Ile Val Leu Pro Asp Gly Arg Val Ile Pro Lys 
                405                 410                 415     


Gly Ile Ile Cys Leu Ile Ser Val Phe Gly Thr His His Asn Pro Ala 
            420                 425                 430         


Val Trp Pro Asp Pro Glu Val Tyr Asp Pro Phe Arg Phe Asp Pro Glu 
        435                 440                 445             


Asn Ile Lys Glu Arg Ser Pro Leu Ala Phe Ile Pro Phe Ser Ala Gly 
    450                 455                 460                 


Pro Arg Asn Cys Ile Gly Gln Thr Phe Ala Met Ala Glu Met Lys Val 
465                 470                 475                 480 


Val Leu Ala Leu Thr Leu Leu Arg Phe Arg Val Leu Pro Asp His Thr 
                485                 490                 495     


Glu Pro Arg Arg Lys Pro Glu Leu Val Leu Arg Ala Glu Gly Gly Leu 
            500                 505                 510         


Trp Leu Arg Val Glu Pro Leu Ser 
        515                 520 


<210>  3921
<211>  74
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3921

Xaa Trp Val Leu Tyr His Leu Ala Lys His Pro Glu Tyr Gln Glu Arg 
1               5                   10                  15      


Cys Arg Gln Glu Val Gln Glu Leu Leu Lys Asp Arg Glu Pro Lys Glu 
            20                  25                  30          


Ile Glu Trp Ser Thr Thr Pro Phe Ala Leu Thr Gln Arg Thr Ser Arg 
        35                  40                  45              


Arg Gly His Leu Trp Leu Leu Phe Pro Ser Arg Gln Gly Pro Gly Thr 
    50                  55                  60                  


Ala Ser Gly Arg Arg Ser Arg Trp Arg Arg 
65                  70                  


<210>  3922
<211>  381
<212>  PRT
<213>  Homo Sapiens

<400>  3922

Met Ser Ser Arg Ile Ala Arg Ala Leu Ala Leu Val Val Thr Leu Leu 
1               5                   10                  15      


His Leu Thr Arg Leu Ala Leu Ser Thr Cys Pro Ala Ala Cys His Cys 
            20                  25                  30          


Pro Leu Glu Ala Pro Lys Cys Ala Pro Gly Val Gly Leu Val Arg Asp 
        35                  40                  45              


Gly Cys Gly Cys Cys Lys Val Cys Ala Lys Gln Leu Asn Glu Asp Cys 
    50                  55                  60                  


Ser Lys Thr Gln Pro Cys Asp His Thr Lys Gly Leu Glu Cys Asn Phe 
65                  70                  75                  80  


Gly Ala Ser Ser Thr Ala Leu Lys Gly Ile Cys Arg Ala Gln Ser Glu 
                85                  90                  95      


Gly Arg Pro Cys Glu Tyr Asn Ser Arg Ile Tyr Gln Asn Gly Glu Ser 
            100                 105                 110         


Phe Gln Pro Asn Cys Lys His Gln Cys Thr Cys Ile Asp Gly Ala Val 
        115                 120                 125             


Gly Cys Ile Pro Leu Cys Pro Gln Glu Leu Ser Leu Pro Asn Leu Gly 
    130                 135                 140                 


Cys Pro Asn Pro Arg Leu Val Lys Val Thr Gly Gln Cys Cys Glu Glu 
145                 150                 155                 160 


Trp Val Cys Asp Glu Asp Ser Ile Lys Asp Pro Met Glu Asp Gln Asp 
                165                 170                 175     


Gly Leu Leu Gly Lys Glu Leu Gly Phe Asp Ala Ser Glu Val Glu Leu 
            180                 185                 190         


Thr Arg Asn Asn Glu Leu Ile Ala Val Gly Lys Gly Ser Ser Leu Lys 
        195                 200                 205             


Arg Leu Pro Val Phe Gly Met Glu Pro Arg Ile Leu Tyr Asn Pro Leu 
    210                 215                 220                 


Gln Gly Gln Lys Cys Ile Val Gln Thr Thr Ser Trp Ser Gln Cys Ser 
225                 230                 235                 240 


Lys Thr Cys Gly Thr Gly Ile Ser Thr Arg Val Thr Asn Asp Asn Pro 
                245                 250                 255     


Glu Cys Arg Leu Val Lys Glu Thr Arg Ile Cys Glu Val Arg Pro Cys 
            260                 265                 270         


Gly Gln Pro Val Tyr Ser Ser Leu Lys Lys Gly Lys Lys Cys Ser Lys 
        275                 280                 285             


Thr Lys Lys Ser Pro Glu Pro Val Arg Phe Thr Tyr Ala Gly Cys Leu 
    290                 295                 300                 


Ser Val Lys Lys Tyr Arg Pro Lys Tyr Cys Gly Ser Cys Val Asp Gly 
305                 310                 315                 320 


Arg Cys Cys Thr Pro Gln Leu Thr Arg Thr Val Lys Met Arg Phe Arg 
                325                 330                 335     


Cys Glu Asp Gly Glu Thr Phe Ser Lys Asn Val Met Met Ile Gln Ser 
            340                 345                 350         


Cys Lys Cys Asn Tyr Asn Cys Pro His Ala Asn Glu Ala Ala Phe Pro 
        355                 360                 365             


Phe Tyr Arg Leu Phe Asn Asp Ile His Lys Phe Arg Asp 
    370                 375                 380     


<210>  3923
<211>  136
<212>  PRT
<213>  Homo Sapiens

<400>  3923

Met Arg Thr Pro Gly Pro Leu Pro Val Leu Leu Leu Leu Leu Ala Gly 
1               5                   10                  15      


Ala Pro Ala Ala Arg Pro Thr Pro Pro Thr Cys Tyr Ser Arg Met Arg 
            20                  25                  30          


Ala Leu Ser Gln Glu Ile Thr Arg Asp Phe Asn Leu Leu Gln Val Ser 
        35                  40                  45              


Glu Pro Ser Glu Pro Cys Val Arg Tyr Leu Pro Arg Leu Tyr Leu Asp 
    50                  55                  60                  


Ile His Asn Tyr Cys Val Leu Asp Lys Leu Arg Asp Phe Val Ala Ser 
65                  70                  75                  80  


Pro Pro Cys Trp Lys Val Ala Gln Val Asp Ser Leu Lys Asp Lys Ala 
                85                  90                  95      


Arg Lys Leu Tyr Thr Ile Met Asn Ser Phe Cys Arg Arg Asp Leu Val 
            100                 105                 110         


Phe Leu Leu Asp Asp Cys Asn Ala Leu Glu Tyr Pro Ile Pro Val Thr 
        115                 120                 125             


Thr Val Leu Pro Asp Arg Gln Arg 
    130                 135     


<210>  3924
<211>  76
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3924

Xaa Pro Gly Pro Leu Pro Val Leu Leu Leu Leu Leu Ala Gly Ala Pro 
1               5                   10                  15      


Ala Ala Arg Pro Thr Pro Pro Thr Cys Tyr Ser Arg Met Arg Ala Leu 
            20                  25                  30          


Ser Gln Glu Ile Thr Arg Asp Phe Asn Leu Leu Gln Val Ser Glu Pro 
        35                  40                  45              


Ser Asp Leu Val Phe Leu Leu Asp Asp Cys Asn Ala Leu Glu Tyr Pro 
    50                  55                  60                  


Ile Pro Val Thr Thr Val Leu Pro Asp Arg Gln Arg 
65                  70                  75      


<210>  3925
<211>  92
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3925

Xaa Thr Pro Gly Pro Leu Pro Val Leu Leu Leu Leu Leu Ala Gly Ala 
1               5                   10                  15      


Pro Ala Ala Arg Pro Thr Pro Pro Thr Cys Tyr Ser Arg Met Arg Ala 
            20                  25                  30          


Leu Ser Gln Glu Ile Thr Arg Asp Phe Asn Leu Leu Gln Val Ser Glu 
        35                  40                  45              


Pro Ser Glu Pro Cys Val Arg Tyr Leu Pro Arg Leu Tyr Leu Asp Ile 
    50                  55                  60                  


His Asp Leu Val Phe Leu Leu Asp Asp Cys Asn Ala Leu Glu Tyr Pro 
65                  70                  75                  80  


Ile Pro Val Thr Thr Val Leu Pro Asp Arg Gln Arg 
                85                  90          


<210>  3926
<211>  78
<212>  PRT
<213>  Homo Sapiens

<400>  3926

Gly Asn Thr Gly Met Val Gly Gly Ser Val Pro Val Phe Asp Glu Ile 
1               5                   10                  15      


Ile Leu Ser Thr Ala Arg Met Asn Arg Val Leu Ser Phe His Ser Val 
            20                  25                  30          


Ser Glu Ser Pro Phe Tyr Val Leu Ile Glu Thr Ser Gly Ser Asn Ala 
        35                  40                  45              


Gly His Asp Ala Glu Lys Leu Gly His Phe Leu Glu His Ala Leu Gly 
    50                  55                  60                  


Ser Gly Leu Val Thr Asp Gly Thr Met Ala Thr Asp Gln Arg 
65                  70                  75              


<210>  3927
<211>  243
<212>  PRT
<213>  Homo Sapiens

<400>  3927

Met Leu Pro Arg Arg Pro Leu Ala Trp Pro Ala Trp Leu Leu Arg Gly 
1               5                   10                  15      


Ala Pro Gly Ala Ala Gly Ser Trp Gly Arg Pro Val Gly Pro Leu Ala 
            20                  25                  30          


Arg Arg Gly Cys Cys Ser Ala Pro Gly Thr Pro Glu Val Pro Leu Thr 
        35                  40                  45              


Arg Glu Arg Tyr Pro Val Arg Arg Leu Pro Phe Ser Thr Val Ser Lys 
    50                  55                  60                  


Gln Asp Leu Ala Ala Phe Glu Arg Ile Val Pro Gly Gly Val Val Thr 
65                  70                  75                  80  


Asp Pro Glu Ala Leu Gln Ala Pro Asn Val Asp Trp Leu Arg Thr Leu 
                85                  90                  95      


Arg Gly Cys Ser Lys Val Leu Leu Arg Pro Arg Thr Ser Glu Glu Val 
            100                 105                 110         


Ser His Ile Leu Arg His Cys His Glu Arg Asn Leu Ala Val Asn Pro 
        115                 120                 125             


Gln Gly Gly Asn Thr Gly Met Val Gly Gly Ser Val Pro Val Phe Asp 
    130                 135                 140                 


Glu Ile Ile Leu Ser Thr Ala Arg Met Asn Arg Val Leu Ser Phe His 
145                 150                 155                 160 


Ser Val Ser Gly Gly Leu Arg Pro Gly Gly Ala Glu Pro Val Cys Gly 
                165                 170                 175     


Gly Thr Gly Leu His His Ala Ala Gly Leu Arg Ser Gln Gly Gln Leu 
            180                 185                 190         


Pro His Arg Gly Lys Arg Gly Asn Gln Arg Trp Arg Pro Ala Val Ser 
        195                 200                 205             


Ser Ile Trp Leu Thr Ala Trp Asp Cys Pro Gly Pro Gly Ser Gly Ala 
    210                 215                 220                 


Gly Arg Arg His Cys Pro Gly Leu Pro Asp Leu Pro Glu Glu Gly Gln 
225                 230                 235                 240 


His Gly Leu 
            


<210>  3928
<211>  521
<212>  PRT
<213>  Homo Sapiens

<400>  3928

Met Leu Pro Arg Arg Pro Leu Ala Trp Pro Ala Trp Leu Leu Arg Gly 
1               5                   10                  15      


Ala Pro Gly Ala Ala Gly Ser Trp Gly Arg Pro Val Gly Pro Leu Ala 
            20                  25                  30          


Arg Arg Gly Cys Cys Ser Ala Pro Gly Thr Pro Glu Val Pro Leu Thr 
        35                  40                  45              


Arg Glu Arg Tyr Pro Val Arg Arg Leu Pro Phe Ser Thr Val Ser Lys 
    50                  55                  60                  


Gln Asp Leu Ala Ala Phe Glu Arg Ile Val Pro Gly Gly Val Val Thr 
65                  70                  75                  80  


Asp Pro Glu Ala Leu Gln Ala Pro Asn Val Asp Trp Leu Arg Thr Leu 
                85                  90                  95      


Arg Gly Cys Ser Lys Val Leu Leu Arg Pro Arg Thr Ser Glu Glu Val 
            100                 105                 110         


Ser His Ile Leu Arg His Cys His Glu Arg Asn Leu Ala Val Asn Pro 
        115                 120                 125             


Gln Gly Gly Asn Thr Gly Met Val Gly Gly Ser Val Pro Val Phe Asp 
    130                 135                 140                 


Glu Ile Ile Leu Ser Thr Ala Arg Met Asn Arg Val Leu Ser Phe His 
145                 150                 155                 160 


Ser Val Ser Gly Ile Leu Val Cys Gln Ala Gly Cys Val Leu Glu Glu 
                165                 170                 175     


Leu Ser Arg Tyr Val Glu Glu Arg Asp Phe Ile Met Pro Leu Asp Leu 
            180                 185                 190         


Gly Ala Lys Gly Ser Cys His Ile Gly Gly Asn Val Ala Thr Asn Ala 
        195                 200                 205             


Gly Gly Leu Arg Phe Leu Arg Tyr Gly Ser Leu His Gly Thr Val Leu 
    210                 215                 220                 


Gly Leu Glu Val Val Leu Ala Asp Gly Thr Val Leu Asp Cys Leu Thr 
225                 230                 235                 240 


Ser Leu Arg Lys Asp Asn Thr Gly Tyr Asp Leu Lys Gln Leu Phe Ile 
                245                 250                 255     


Gly Ser Glu Gly Thr Leu Gly Ile Ile Thr Thr Val Ser Ile Leu Cys 
            260                 265                 270         


Pro Pro Lys Pro Arg Ala Val Asn Val Ala Phe Leu Gly Cys Pro Gly 
        275                 280                 285             


Phe Ala Glu Val Leu Gln Thr Phe Ser Thr Cys Lys Gly Met Leu Gly 
    290                 295                 300                 


Glu Ile Leu Ser Ala Phe Glu Phe Met Asp Ala Val Cys Met Gln Leu 
305                 310                 315                 320 


Val Gly Arg His Leu His Leu Ala Ser Pro Val Gln Glu Ser Pro Phe 
                325                 330                 335     


Tyr Val Leu Ile Glu Thr Ser Gly Ser Asn Ala Gly His Asp Ala Glu 
            340                 345                 350         


Lys Leu Gly His Phe Leu Glu His Ala Leu Gly Ser Gly Leu Val Thr 
        355                 360                 365             


Asp Gly Thr Met Ala Thr Asp Gln Arg Lys Val Lys Met Leu Trp Ala 
    370                 375                 380                 


Leu Arg Glu Arg Ile Thr Glu Ala Leu Ser Arg Asp Gly Tyr Val Tyr 
385                 390                 395                 400 


Lys Tyr Asp Leu Ser Leu Pro Val Glu Arg Leu Tyr Asp Ile Val Thr 
                405                 410                 415     


Asp Leu Arg Ala Arg Leu Gly Pro His Ala Lys His Val Val Gly Tyr 
            420                 425                 430         


Gly His Leu Gly Asp Gly Asn Leu His Leu Asn Val Thr Ala Glu Ala 
        435                 440                 445             


Phe Ser Pro Ser Leu Leu Ala Ala Leu Glu Pro His Val Tyr Glu Trp 
    450                 455                 460                 


Thr Ala Gly Gln Gln Gly Ser Val Ser Ala Glu His Gly Val Gly Phe 
465                 470                 475                 480 


Arg Lys Arg Asp Val Leu Gly Tyr Ser Lys Pro Pro Gly Ala Leu Gln 
                485                 490                 495     


Leu Met Gln Gln Leu Lys Ala Leu Leu Asp Pro Lys Gly Ile Leu Asn 
            500                 505                 510         


Pro Tyr Lys Thr Leu Pro Ser Gln Ala 
        515                 520     


<210>  3929
<211>  320
<212>  PRT
<213>  Homo Sapiens

<400>  3929

Met Leu Pro Arg Arg Pro Leu Ala Trp Pro Ala Trp Leu Leu Arg Gly 
1               5                   10                  15      


Ala Pro Gly Ala Ala Gly Ser Trp Gly Arg Pro Val Gly Pro Leu Ala 
            20                  25                  30          


Arg Arg Gly Cys Cys Ser Ala Pro Gly Thr Pro Glu Val Pro Leu Thr 
        35                  40                  45              


Arg Glu Arg Tyr Pro Val Arg Arg Leu Pro Phe Ser Thr Val Ser Lys 
    50                  55                  60                  


Gln Asp Leu Ala Ala Phe Glu Arg Ile Val Pro Gly Gly Val Val Thr 
65                  70                  75                  80  


Asp Pro Glu Ala Leu Gln Ala Pro Asn Val Asp Trp Leu Arg Thr Leu 
                85                  90                  95      


Arg Gly Cys Ser Lys Val Leu Leu Arg Pro Arg Thr Ser Glu Glu Val 
            100                 105                 110         


Ser His Ile Leu Arg His Cys His Glu Arg Asn Leu Ala Val Asn Pro 
        115                 120                 125             


Gln Gly Gly Asn Thr Gly Met Val Gly Gly Ser Val Pro Val Phe Asp 
    130                 135                 140                 


Glu Ile Ile Leu Ser Thr Ala Arg Met Asn Arg Val Leu Ser Phe His 
145                 150                 155                 160 


Ser Val Ser Gly Ile Leu Val Cys Gln Ala Gly Cys Val Leu Glu Glu 
                165                 170                 175     


Leu Ser Arg Tyr Val Glu Glu Arg Asp Phe Ile Met Pro Leu Asp Leu 
            180                 185                 190         


Gly Ala Lys Gly Ser Cys His Ile Gly Gly Asn Val Ala Thr Asn Ala 
        195                 200                 205             


Gly Gly Leu Arg Phe Leu Arg Tyr Gly Ser Leu His Gly Thr Val Leu 
    210                 215                 220                 


Gly Leu Glu Val Val Leu Ala Asp Gly Thr Val Leu Asp Cys Leu Thr 
225                 230                 235                 240 


Ser Leu Arg Lys Asp Asn Thr Gly Tyr Asp Leu Lys Gln Leu Phe Ile 
                245                 250                 255     


Gly Ser Glu Gly Thr Leu Gly Ile Ile Thr Thr Val Ser Ile Leu Cys 
            260                 265                 270         


Pro Pro Lys Pro Arg Ala Val Asn Val Ala Phe Leu Asp Ala Val Gly 
        275                 280                 285             


Pro Glu Gly Lys Asp His Arg Gly Ala Glu Pro Gly Trp Leu Arg Val 
    290                 295                 300                 


Gln Val Arg Pro Leu Pro Pro Cys Gly Ala Ala Leu Arg His Arg Asp 
305                 310                 315                 320 


<210>  3930
<211>  387
<212>  PRT
<213>  Homo Sapiens

<400>  3930

Met Val Gly Gly Ser Val Pro Val Phe Asp Glu Ile Ile Leu Ser Thr 
1               5                   10                  15      


Ala Arg Met Asn Arg Val Leu Ser Phe His Ser Val Ser Gly Ile Leu 
            20                  25                  30          


Val Cys Gln Ala Gly Cys Val Leu Glu Glu Leu Ser Arg Tyr Val Glu 
        35                  40                  45              


Glu Arg Asp Phe Ile Met Pro Leu Asp Leu Gly Ala Lys Gly Ser Cys 
    50                  55                  60                  


His Ile Gly Gly Asn Val Ala Thr Asn Ala Gly Gly Leu Arg Phe Leu 
65                  70                  75                  80  


Arg Tyr Gly Ser Leu His Gly Thr Val Leu Gly Leu Glu Val Val Leu 
                85                  90                  95      


Ala Asp Gly Thr Val Leu Asp Cys Leu Thr Ser Leu Arg Lys Asp Asn 
            100                 105                 110         


Thr Gly Tyr Asp Leu Lys Gln Leu Phe Ile Gly Ser Glu Gly Thr Leu 
        115                 120                 125             


Gly Ile Ile Thr Thr Val Ser Ile Leu Cys Pro Pro Lys Pro Arg Ala 
    130                 135                 140                 


Val Asn Val Ala Phe Leu Gly Cys Pro Gly Phe Ala Glu Val Leu Gln 
145                 150                 155                 160 


Thr Phe Ser Thr Cys Lys Gly Met Leu Gly Glu Ile Leu Ser Ala Phe 
                165                 170                 175     


Glu Phe Met Asp Ala Val Cys Met Gln Leu Val Gly Arg His Leu His 
            180                 185                 190         


Leu Ala Ser Pro Val Gln Glu Ser Pro Phe Tyr Val Leu Ile Glu Thr 
        195                 200                 205             


Ser Gly Ser Asn Ala Gly His Asp Ala Glu Lys Leu Gly His Phe Leu 
    210                 215                 220                 


Glu His Ala Leu Gly Ser Gly Leu Val Thr Asp Gly Thr Met Ala Thr 
225                 230                 235                 240 


Asp Gln Arg Lys Val Lys Met Leu Trp Ala Leu Arg Glu Arg Ile Thr 
                245                 250                 255     


Glu Ala Leu Ser Arg Asp Gly Tyr Val Tyr Lys Tyr Asp Leu Ser Leu 
            260                 265                 270         


Pro Val Glu Arg Leu Tyr Asp Ile Val Thr Asp Leu Arg Ala Arg Leu 
        275                 280                 285             


Gly Pro His Ala Lys His Val Val Gly Tyr Gly His Leu Gly Asp Gly 
    290                 295                 300                 


Asn Leu His Leu Asn Val Thr Ala Glu Ala Phe Ser Pro Ser Leu Leu 
305                 310                 315                 320 


Ala Ala Leu Glu Pro His Val Tyr Glu Trp Thr Ala Gly Gln Gln Gly 
                325                 330                 335     


Ser Val Ser Ala Glu His Gly Val Gly Phe Arg Lys Arg Asp Val Leu 
            340                 345                 350         


Gly Tyr Ser Lys Pro Pro Gly Ala Leu Gln Leu Met Gln Gln Leu Lys 
        355                 360                 365             


Ala Leu Leu Asp Pro Lys Gly Ile Leu Asn Pro Tyr Lys Thr Leu Pro 
    370                 375                 380                 


Ser Gln Ala 
385         


<210>  3931
<211>  90
<212>  PRT
<213>  Homo Sapiens

<400>  3931

Arg His Cys His Glu Arg Asn Leu Ala Val Asn Pro Gln Gly Gly Asn 
1               5                   10                  15      


Thr Gly Met Val Gly Gly Ser Val Pro Val Phe Asp Glu Ile Ile Leu 
            20                  25                  30          


Ser Thr Ala Arg Met Asn Arg Val Leu Ser Phe His Ser Val Ser Gly 
        35                  40                  45              


Cys Pro Gly Phe Ala Glu Val Leu Gln Thr Phe Ser Thr Cys Lys Gly 
    50                  55                  60                  


Met Leu Gly Glu Ile Leu Ser Ala Phe Glu Phe Met Asp Ala Val Cys 
65                  70                  75                  80  


Met Gln Leu Val Gly Arg His Leu His Leu 
                85                  90  


<210>  3932
<211>  152
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3932

Xaa His Ser Val Ser Gly Ile Leu Val Cys Gln Ala Gly Cys Val Leu 
1               5                   10                  15      


Glu Glu Leu Ser Arg Tyr Val Glu Glu Arg Asp Phe Ile Met Pro Leu 
            20                  25                  30          


Asp Leu Gly Ala Lys Gly Ser Cys His Ile Gly Gly Asn Val Ala Thr 
        35                  40                  45              


Asn Ala Gly Gly Leu Arg Phe Leu Arg Tyr Gly Ser Leu His Gly Thr 
    50                  55                  60                  


Val Leu Gly Leu Glu Val Val Leu Ala Asp Gly Thr Val Leu Asp Cys 
65                  70                  75                  80  


Leu Thr Ser Leu Arg Lys Asp Asn Thr Gly Tyr Asp Leu Lys Gln Leu 
                85                  90                  95      


Phe Ile Gly Ser Glu Gly Thr Leu Gly Ile Ile Thr Thr Val Ser Ile 
            100                 105                 110         


Leu Cys Pro Pro Lys Pro Arg Ala Val Asn Val Ala Phe Leu Gly Phe 
        115                 120                 125             


Leu Cys Ser Ala Leu Ile Pro Leu Gln Leu Gln Ser Pro Val Cys Arg 
    130                 135                 140                 


Pro Pro Val Val Leu Gly Ala Arg 
145                 150         


<210>  3933
<211>  318
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3933

Xaa Ser His Ala Asn His Arg Pro Ile Cys Leu Ser Pro Arg Ile Trp 
1               5                   10                  15      


Pro Gly Ser Ala Ser Ala Thr Ser Thr Val Cys Ser Ser Ser Glu Ser 
            20                  25                  30          


Phe Leu Pro Arg Gly Pro Pro Ala Val Ser Leu Leu Leu His Gly Pro 
        35                  40                  45              


Pro Thr Val Ser Phe Pro Pro Pro Trp Pro Thr His His Val Leu Pro 
    50                  55                  60                  


Ser Pro Val Ala His Pro Pro Cys Pro Cys Leu Pro Pro Asp Met Pro 
65                  70                  75                  80  


Leu Glu Leu Pro Gly Pro Cys Cys Cys Pro His Cys Leu Cys Asp Ser 
                85                  90                  95      


Ala Pro Pro Ser Leu Pro Cys Pro Thr Leu Val Gln Gly Ala Ser Arg 
            100                 105                 110         


Pro Ile Leu Ile Leu Arg Ala Phe Pro Gly Pro Cys His Ser Val Pro 
        115                 120                 125             


Cys His Asp Leu Lys Leu Gln Val Gly Ala Ser Pro Phe Arg His Gly 
    130                 135                 140                 


Cys Pro Pro Ser Val Arg Cys Pro Ser Arg Leu Ile Ala Gly Val Pro 
145                 150                 155                 160 


Gly Cys Ser Val Leu Ser Trp Ser Leu Gly His Ser Leu Ser Gly Ile 
                165                 170                 175     


Asp Ser Arg Met Leu Trp Ala Leu Arg Glu Arg Ile Thr Glu Ala Leu 
            180                 185                 190         


Ser Arg Asp Gly Tyr Val Tyr Lys Tyr Asp Leu Ser Leu Pro Val Glu 
        195                 200                 205             


Arg Leu Tyr Asp Ile Val Thr Asp Leu Arg Ala Arg Leu Gly Pro His 
    210                 215                 220                 


Ala Lys His Val Val Gly Tyr Gly His Leu Gly Asp Gly Asn Leu His 
225                 230                 235                 240 


Leu Asn Val Thr Ala Glu Ala Phe Ser Pro Ser Leu Leu Ala Ala Leu 
                245                 250                 255     


Glu Pro His Val Tyr Glu Trp Thr Ala Gly Gln Gln Gly Ser Val Ser 
            260                 265                 270         


Ala Glu His Gly Val Gly Phe Arg Lys Arg Asp Val Leu Gly Tyr Ser 
        275                 280                 285             


Lys Pro Pro Gly Ala Leu Gln Leu Met Gln Gln Leu Lys Ala Leu Leu 
    290                 295                 300                 


Asp Pro Lys Gly Ile Leu Asn Pro Tyr Lys Thr Leu Pro Ser 
305                 310                 315             


<210>  3934
<211>  189
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3934

Xaa Ser Val Phe Cys Ser Asp Pro Thr Pro Thr Ala Val Thr Cys Val 
1               5                   10                  15      


Pro Pro Ala Cys Gly Pro Gly Ser Pro Arg Pro Ala Arg Leu Pro His 
            20                  25                  30          


Pro Ala Leu Arg Thr Pro Gly Cys Pro Gly Phe Ala Glu Val Leu Gln 
        35                  40                  45              


Thr Phe Ser Thr Cys Lys Gly Met Leu Gly Glu Ile Leu Ser Ala Phe 
    50                  55                  60                  


Glu Phe Met Asp Ala Val Cys Met Gln Leu Val Gly Arg His Leu His 
65                  70                  75                  80  


Leu Ala Ser Pro Val Gln Glu Ser Pro Phe Tyr Val Leu Ile Glu Thr 
                85                  90                  95      


Ser Gly Ser Asn Ala Gly His Asp Ala Glu Lys Leu Gly His Phe Leu 
            100                 105                 110         


Glu His Ala Leu Gly Ser Gly Leu Val Thr Asp Gly Thr Met Ala Thr 
        115                 120                 125             


Asp Gln Arg Lys Val Lys Met Leu Trp Ala Leu Arg Glu Arg Ile Thr 
    130                 135                 140                 


Glu Ala Leu Ser Arg Asp Gly Tyr Val Tyr Lys Tyr Asp Leu Ser Leu 
145                 150                 155                 160 


Pro Val Glu Arg Leu Tyr Asp Ile Val Thr Asp Leu Arg Ala Arg Leu 
                165                 170                 175     


Gly Pro His Ala Lys His Val Val Gly Tyr Gly His Leu 
            180                 185                 


<210>  3935
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  3935

Met Arg Met Ser Val Gly Leu Ser Leu 
1               5                   


<210>  3936
<211>  15
<212>  PRT
<213>  Homo Sapiens

<400>  3936

Met Arg Met Ser Val Gly Leu Ser Leu Leu Leu Pro Leu Ser Gly 
1               5                   10                  15  


<210>  3937
<211>  41
<212>  PRT
<213>  Homo Sapiens

<400>  3937

Met Arg Met Ser Val Gly Leu Ser Leu Leu Leu Pro Leu Ser Gly Arg 
1               5                   10                  15      


Thr Phe Leu Leu Leu Leu Ser Val Val Met Ala Gln Ser His Trp Pro 
            20                  25                  30          


Ser Glu Pro Ser Glu Ala Val Arg Asp 
        35                  40      


<210>  3938
<211>  52
<212>  PRT
<213>  Homo Sapiens

<400>  3938

Met Arg Met Ser Val Gly Leu Ser Leu Leu Leu Pro Leu Ser Gly Arg 
1               5                   10                  15      


Thr Phe Leu Leu Leu Leu Ser Val Val Met Ala Gln Ser His Trp Pro 
            20                  25                  30          


Ser Glu Pro Ser Glu Ala Val Arg Asp Trp Glu Asn Gln Leu Glu Ala 
        35                  40                  45              


Ser Met His Ser 
    50          


<210>  3939
<211>  86
<212>  PRT
<213>  Homo Sapiens

<400>  3939

Met Arg Met Ser Val Gly Leu Ser Leu Leu Leu Pro Leu Ser Gly Arg 
1               5                   10                  15      


Thr Phe Leu Leu Leu Leu Ser Val Val Met Ala Gln Ser His Trp Pro 
            20                  25                  30          


Ser Glu Pro Ser Glu Ala Val Arg Asp Trp Glu Asn Gln Leu Glu Ala 
        35                  40                  45              


Ser Met His Ser Val Leu Ser Asp Leu His Glu Ala Val Pro Thr Val 
    50                  55                  60                  


Val Gly Ile Pro Asp Gly Thr Ala Val Val Gly Arg Ser Phe Arg Val 
65                  70                  75                  80  


Thr Ile Pro Thr Asp Leu 
                85      


<210>  3940
<211>  88
<212>  PRT
<213>  Homo Sapiens

<400>  3940

Met Arg Met Ser Val Gly Leu Ser Leu Leu Leu Pro Leu Ser Gly Arg 
1               5                   10                  15      


Thr Phe Leu Leu Leu Leu Ser Val Val Met Ala Gln Ser His Trp Pro 
            20                  25                  30          


Ser Glu Pro Ser Glu Ala Val Arg Asp Trp Glu Asn Gln Leu Glu Ala 
        35                  40                  45              


Ser Met His Ser Val Leu Ser Asp Leu His Glu Ala Val Pro Thr Val 
    50                  55                  60                  


Val Gly Ile Pro Asp Gly Thr Ala Val Val Gly Arg Ser Phe Arg Val 
65                  70                  75                  80  


Thr Ile Pro Thr Asp Leu Ile Ala 
                85              


<210>  3941
<211>  96
<212>  PRT
<213>  Homo Sapiens

<400>  3941

Met Arg Met Ser Val Gly Leu Ser Leu Leu Leu Pro Leu Ser Gly Arg 
1               5                   10                  15      


Thr Phe Leu Leu Leu Leu Ser Val Val Met Ala Gln Ser His Trp Pro 
            20                  25                  30          


Ser Glu Pro Ser Glu Ala Val Arg Asp Trp Glu Asn Gln Leu Glu Ala 
        35                  40                  45              


Ser Met His Ser Val Leu Ser Asp Leu His Glu Ala Val Pro Thr Val 
    50                  55                  60                  


Val Gly Ile Pro Asp Gly Thr Ala Val Val Gly Arg Ser Phe Arg Val 
65                  70                  75                  80  


Thr Ile Pro Thr Asp Leu Ile Ala Ser Ser Gly Asp Ile Ile Lys Val 
                85                  90                  95      


<210>  3942
<211>  106
<212>  PRT
<213>  Homo Sapiens

<400>  3942

Met Arg Met Ser Val Gly Leu Ser Leu Leu Leu Pro Leu Ser Gly Arg 
1               5                   10                  15      


Thr Phe Leu Leu Leu Leu Ser Val Val Met Ala Gln Ser His Trp Pro 
            20                  25                  30          


Ser Glu Pro Ser Glu Ala Val Arg Asp Trp Glu Asn Gln Leu Glu Ala 
        35                  40                  45              


Ser Met His Ser Val Leu Ser Asp Leu His Glu Ala Val Pro Thr Val 
    50                  55                  60                  


Val Gly Ile Pro Asp Gly Thr Ala Val Val Gly Arg Ser Phe Arg Val 
65                  70                  75                  80  


Thr Ile Pro Thr Asp Leu Ile Ala Ser Ser Gly Asp Ile Ile Lys Val 
                85                  90                  95      


Ser Ala Ala Gly Lys Glu Ala Leu Pro Ser 
            100                 105     


<210>  3943
<211>  117
<212>  PRT
<213>  Homo Sapiens

<400>  3943

Met Arg Met Ser Val Gly Leu Ser Leu Leu Leu Pro Leu Ser Gly Arg 
1               5                   10                  15      


Thr Phe Leu Leu Leu Leu Ser Val Val Met Ala Gln Ser His Trp Pro 
            20                  25                  30          


Ser Glu Pro Ser Glu Ala Val Arg Asp Trp Glu Asn Gln Leu Glu Ala 
        35                  40                  45              


Ser Met His Ser Val Leu Ser Asp Leu His Glu Ala Val Pro Thr Val 
    50                  55                  60                  


Val Gly Ile Pro Asp Gly Thr Ala Val Val Gly Arg Ser Phe Arg Val 
65                  70                  75                  80  


Thr Ile Pro Thr Asp Leu Ile Ala Ser Ser Gly Asp Ile Ile Lys Val 
                85                  90                  95      


Ser Ala Ala Gly Lys Glu Ala Leu Pro Ser Trp Leu His Trp Asp Ser 
            100                 105                 110         


Gln Ser His Thr Leu 
        115         


<210>  3944
<211>  895
<212>  PRT
<213>  Homo Sapiens

<400>  3944

Met Arg Met Ser Val Gly Leu Ser Leu Leu Leu Pro Leu Ser Gly Arg 
1               5                   10                  15      


Thr Phe Leu Leu Leu Leu Ser Val Val Met Ala Gln Ser His Trp Pro 
            20                  25                  30          


Ser Glu Pro Ser Glu Ala Val Arg Asp Trp Glu Asn Gln Leu Glu Ala 
        35                  40                  45              


Ser Met His Ser Val Leu Ser Asp Leu His Glu Ala Val Pro Thr Val 
    50                  55                  60                  


Val Gly Ile Pro Asp Gly Thr Ala Val Val Gly Arg Ser Phe Arg Val 
65                  70                  75                  80  


Thr Ile Pro Thr Asp Leu Ile Ala Ser Ser Gly Asp Ile Ile Lys Val 
                85                  90                  95      


Ser Ala Ala Gly Lys Glu Ala Leu Pro Ser Trp Leu His Trp Asp Ser 
            100                 105                 110         


Gln Ser His Thr Leu Glu Gly Leu Pro Leu Asp Thr Asp Lys Gly Val 
        115                 120                 125             


His Tyr Ile Ser Val Ser Ala Thr Arg Leu Gly Ala Asn Gly Ser His 
    130                 135                 140                 


Ile Pro Gln Thr Ser Ser Val Phe Ser Ile Glu Val Tyr Pro Glu Asp 
145                 150                 155                 160 


His Ser Glu Leu Gln Ser Val Arg Thr Ala Ser Pro Asp Pro Gly Glu 
                165                 170                 175     


Val Val Ser Ser Ala Cys Ala Ala Asp Glu Pro Val Thr Val Leu Thr 
            180                 185                 190         


Val Ile Leu Asp Ala Asp Leu Thr Lys Met Thr Pro Lys Gln Arg Ile 
        195                 200                 205             


Asp Leu Leu His Arg Met Arg Ser Phe Ser Glu Val Glu Leu His Asn 
    210                 215                 220                 


Met Lys Leu Val Pro Val Val Asn Asn Arg Leu Phe Asp Met Ser Ala 
225                 230                 235                 240 


Phe Met Ala Gly Pro Gly Asn Ala Lys Lys Val Val Glu Asn Gly Ala 
                245                 250                 255     


Leu Leu Ser Trp Lys Leu Gly Cys Ser Leu Asn Gln Asn Ser Val Pro 
            260                 265                 270         


Asp Ile His Gly Val Glu Ala Pro Ala Arg Glu Gly Ala Met Ser Ala 
        275                 280                 285             


Gln Leu Gly Tyr Pro Val Val Gly Trp His Ile Ala Asn Lys Lys Pro 
    290                 295                 300                 


Pro Leu Pro Lys Arg Val Arg Arg Gln Ile His Ala Thr Pro Thr Pro 
305                 310                 315                 320 


Val Thr Ala Ile Gly Pro Pro Thr Thr Ala Ile Gln Glu Pro Pro Ser 
                325                 330                 335     


Arg Ile Val Pro Thr Pro Thr Ser Pro Ala Ile Ala Pro Pro Thr Glu 
            340                 345                 350         


Thr Met Ala Pro Pro Val Arg Asp Pro Val Pro Gly Lys Pro Thr Val 
        355                 360                 365             


Thr Ile Arg Thr Arg Gly Ala Ile Ile Gln Thr Pro Thr Leu Gly Pro 
    370                 375                 380                 


Ile Gln Pro Thr Arg Val Ser Glu Ala Gly Thr Thr Val Pro Gly Gln 
385                 390                 395                 400 


Ile Arg Pro Thr Met Thr Ile Pro Gly Tyr Val Glu Pro Thr Ala Val 
                405                 410                 415     


Ala Thr Pro Pro Thr Thr Thr Thr Lys Lys Pro Arg Val Ser Thr Pro 
            420                 425                 430         


Lys Pro Ala Thr Pro Ser Thr Asp Ser Thr Thr Thr Thr Thr Arg Arg 
        435                 440                 445             


Pro Thr Lys Lys Pro Arg Thr Pro Arg Pro Val Pro Arg Val Thr Thr 
    450                 455                 460                 


Lys Val Ser Ile Thr Arg Leu Glu Thr Ala Ser Pro Pro Thr Arg Ile 
465                 470                 475                 480 


Arg Thr Thr Thr Ser Gly Val Pro Arg Gly Gly Glu Pro Asn Gln Arg 
                485                 490                 495     


Pro Glu Leu Lys Asn His Ile Asp Arg Val Asp Ala Trp Val Gly Thr 
            500                 505                 510         


Tyr Phe Glu Val Lys Ile Pro Ser Asp Thr Phe Tyr Asp His Glu Asp 
        515                 520                 525             


Thr Thr Thr Asp Lys Leu Lys Leu Thr Leu Lys Leu Arg Glu Gln Gln 
    530                 535                 540                 


Leu Val Gly Glu Lys Ser Trp Val Gln Phe Asn Ser Asn Ser Gln Leu 
545                 550                 555                 560 


Met Tyr Gly Leu Pro Asp Ser Ser His Val Gly Lys His Glu Tyr Phe 
                565                 570                 575     


Met His Ala Thr Asp Lys Gly Gly Leu Ser Ala Val Asp Ala Phe Glu 
            580                 585                 590         


Ile His Val His Arg Arg Pro Gln Gly Asp Arg Ala Pro Ala Arg Phe 
        595                 600                 605             


Lys Ala Lys Phe Val Gly Asp Pro Ala Leu Val Leu Asn Asp Ile His 
    610                 615                 620                 


Lys Lys Ile Ala Leu Val Lys Lys Leu Ala Phe Ala Phe Gly Asp Arg 
625                 630                 635                 640 


Asn Cys Ser Thr Ile Thr Leu Gln Asn Ile Thr Arg Gly Ser Ile Val 
                645                 650                 655     


Val Glu Trp Thr Asn Asn Thr Leu Pro Leu Glu Pro Cys Pro Lys Glu 
            660                 665                 670         


Gln Ile Ala Gly Leu Ser Arg Arg Ile Ala Glu Asp Asp Gly Lys Pro 
        675                 680                 685             


Arg Pro Ala Phe Ser Asn Ala Leu Glu Pro Asp Phe Lys Ala Thr Ser 
    690                 695                 700                 


Ile Thr Val Thr Gly Ser Gly Ser Cys Arg His Leu Gln Phe Ile Pro 
705                 710                 715                 720 


Val Val Pro Pro Arg Arg Val Pro Ser Glu Ala Pro Pro Thr Glu Val 
                725                 730                 735     


Pro Asp Arg Asp Pro Glu Lys Ser Ser Glu Asp Asp Val Tyr Leu His 
            740                 745                 750         


Thr Val Ile Pro Ala Val Val Val Ala Ala Ile Leu Leu Ile Ala Gly 
        755                 760                 765             


Ile Ile Ala Met Ile Cys Tyr Arg Lys Lys Arg Lys Gly Lys Leu Thr 
    770                 775                 780                 


Leu Glu Asp Gln Ala Thr Phe Ile Lys Lys Gly Val Pro Ile Ile Phe 
785                 790                 795                 800 


Ala Asp Glu Leu Asp Asp Ser Lys Pro Pro Pro Ser Ser Ser Met Pro 
                805                 810                 815     


Leu Ile Leu Gln Glu Glu Lys Ala Pro Leu Pro Pro Pro Glu Tyr Pro 
            820                 825                 830         


Asn Gln Ser Val Pro Glu Thr Thr Pro Leu Asn Gln Asp Thr Met Gly 
        835                 840                 845             


Glu Tyr Thr Pro Leu Arg Asp Glu Asp Pro Asn Ala Pro Pro Tyr Gln 
    850                 855                 860                 


Pro Pro Pro Pro Phe Thr Ala Pro Met Glu Gly Lys Gly Ser Arg Pro 
865                 870                 875                 880 


Lys Asn Met Thr Pro Tyr Arg Ser Pro Pro Pro Tyr Val Pro Pro 
                885                 890                 895 


<210>  3945
<211>  895
<212>  PRT
<213>  Homo Sapiens

<400>  3945

Met Arg Met Ser Val Gly Leu Ser Leu Leu Leu Pro Leu Ser Gly Arg 
1               5                   10                  15      


Thr Phe Leu Leu Leu Leu Ser Val Val Met Ala Gln Ser His Trp Pro 
            20                  25                  30          


Ser Glu Pro Ser Glu Ala Val Arg Asp Trp Glu Asn Gln Leu Glu Ala 
        35                  40                  45              


Ser Met His Ser Val Leu Ser Asp Leu His Glu Ala Val Pro Thr Val 
    50                  55                  60                  


Val Gly Ile Pro Asp Gly Thr Ala Val Val Gly Arg Ser Phe Arg Val 
65                  70                  75                  80  


Thr Ile Pro Thr Asp Leu Ile Ala Ser Ser Gly Asp Ile Ile Lys Val 
                85                  90                  95      


Ser Ala Ala Gly Lys Glu Ala Leu Pro Ser Trp Leu His Trp Asp Ser 
            100                 105                 110         


Gln Ser His Thr Leu Glu Gly Leu Pro Leu Asp Thr Asp Lys Gly Val 
        115                 120                 125             


His Tyr Ile Ser Val Ser Ala Thr Arg Leu Gly Ala Asn Gly Ser His 
    130                 135                 140                 


Ile Pro Gln Thr Ser Ser Val Phe Ser Ile Glu Val Tyr Pro Glu Asp 
145                 150                 155                 160 


His Ser Glu Leu Gln Ser Val Arg Thr Ala Ser Pro Asp Pro Gly Glu 
                165                 170                 175     


Val Val Ser Ser Ala Cys Ala Ala Asp Glu Pro Val Thr Val Leu Thr 
            180                 185                 190         


Val Ile Leu Asp Ala Asp Leu Thr Lys Met Thr Pro Lys Gln Arg Ile 
        195                 200                 205             


Asp Leu Leu His Arg Met Arg Ser Phe Ser Glu Val Glu Leu His Asn 
    210                 215                 220                 


Met Lys Leu Val Pro Val Val Asn Asn Arg Leu Phe Asp Met Ser Ala 
225                 230                 235                 240 


Phe Met Ala Gly Pro Gly Asn Ala Lys Lys Val Val Glu Asn Gly Ala 
                245                 250                 255     


Leu Leu Ser Trp Lys Leu Gly Cys Ser Leu Asn Gln Asn Ser Val Pro 
            260                 265                 270         


Asp Ile His Gly Val Glu Ala Pro Ala Arg Glu Gly Ala Met Ser Ala 
        275                 280                 285             


Gln Leu Gly Tyr Pro Val Val Gly Trp His Ile Ala Asn Lys Lys Pro 
    290                 295                 300                 


Pro Leu Pro Lys Arg Val Arg Arg Gln Ile His Ala Thr Pro Thr Pro 
305                 310                 315                 320 


Val Thr Ala Ile Gly Pro Pro Thr Thr Ala Ile Gln Glu Pro Pro Ser 
                325                 330                 335     


Arg Ile Val Pro Thr Pro Thr Ser Pro Ala Ile Ala Pro Pro Thr Glu 
            340                 345                 350         


Thr Met Ala Pro Pro Val Arg Asp Pro Val Pro Gly Lys Pro Thr Val 
        355                 360                 365             


Thr Ile Arg Thr Arg Gly Ala Ile Ile Gln Thr Pro Thr Leu Gly Pro 
    370                 375                 380                 


Ile Gln Pro Thr Arg Val Ser Glu Ala Gly Thr Thr Val Pro Gly Gln 
385                 390                 395                 400 


Ile Arg Pro Thr Met Thr Ile Pro Gly Tyr Val Glu Pro Thr Ala Val 
                405                 410                 415     


Ala Thr Pro Pro Thr Thr Thr Thr Lys Lys Pro Arg Val Ser Thr Pro 
            420                 425                 430         


Lys Pro Ala Thr Pro Ser Thr Asp Ser Thr Thr Thr Thr Thr Arg Arg 
        435                 440                 445             


Pro Thr Lys Lys Pro Arg Thr Pro Arg Pro Val Pro Arg Val Thr Thr 
    450                 455                 460                 


Lys Val Ser Ile Thr Arg Leu Glu Thr Ala Ser Pro Pro Thr Arg Ile 
465                 470                 475                 480 


Arg Thr Thr Thr Ser Gly Val Pro Arg Gly Gly Glu Pro Asn Gln Arg 
                485                 490                 495     


Pro Glu Leu Lys Asn His Ile Asp Arg Val Asp Ala Trp Val Gly Thr 
            500                 505                 510         


Tyr Phe Glu Val Lys Ile Pro Ser Asp Thr Phe Tyr Asp His Glu Asp 
        515                 520                 525             


Thr Thr Thr Asp Lys Leu Lys Leu Thr Leu Lys Leu Arg Glu Gln Gln 
    530                 535                 540                 


Leu Val Gly Glu Lys Ser Trp Val Gln Phe Asn Ser Asn Ser Gln Leu 
545                 550                 555                 560 


Met Tyr Gly Leu Pro Asp Ser Ser His Val Gly Lys His Glu Tyr Phe 
                565                 570                 575     


Met His Ala Thr Asp Lys Gly Gly Leu Ser Ala Val Asp Ala Phe Glu 
            580                 585                 590         


Ile His Val His Arg Arg Pro Gln Gly Asp Arg Ala Pro Ala Arg Phe 
        595                 600                 605             


Lys Ala Lys Phe Val Gly Asp Pro Ala Leu Val Leu Asn Asp Ile His 
    610                 615                 620                 


Lys Lys Ile Ala Leu Val Lys Lys Leu Ala Phe Ala Phe Gly Asp Arg 
625                 630                 635                 640 


Asn Cys Ser Thr Ile Thr Leu Gln Asn Ile Thr Arg Gly Ser Ile Val 
                645                 650                 655     


Val Glu Trp Thr Asn Asn Thr Leu Pro Leu Glu Pro Cys Pro Lys Glu 
            660                 665                 670         


Gln Ile Ala Gly Leu Ser Arg Arg Ile Ala Glu Asp Asp Gly Lys Pro 
        675                 680                 685             


Arg Pro Ala Phe Ser Asn Ala Leu Glu Pro Asp Phe Lys Ala Thr Ser 
    690                 695                 700                 


Ile Thr Val Thr Gly Ser Gly Ser Cys Arg His Leu Gln Phe Ile Pro 
705                 710                 715                 720 


Val Val Pro Pro Arg Arg Val Pro Ser Glu Ala Pro Pro Thr Glu Val 
                725                 730                 735     


Pro Asp Arg Asp Pro Glu Lys Ser Ser Glu Asp Asp Val Tyr Leu His 
            740                 745                 750         


Thr Val Ile Pro Ala Val Val Val Ala Ala Ile Leu Leu Ile Ala Gly 
        755                 760                 765             


Ile Ile Ala Met Ile Cys Tyr Arg Lys Lys Arg Lys Gly Lys Leu Thr 
    770                 775                 780                 


Leu Glu Asp Gln Ala Thr Phe Ile Lys Lys Gly Val Pro Ile Ile Phe 
785                 790                 795                 800 


Ala Asp Glu Leu Asp Asp Ser Lys Pro Pro Pro Ser Ser Ser Met Pro 
                805                 810                 815     


Leu Ile Leu Gln Glu Glu Lys Ala Pro Leu Pro Pro Pro Glu Tyr Pro 
            820                 825                 830         


Asn Gln Ser Val Pro Glu Thr Thr Pro Leu Asn Gln Asp Thr Met Gly 
        835                 840                 845             


Glu Tyr Thr Pro Leu Arg Asp Glu Asp Pro Asn Ala Pro Pro Tyr Gln 
    850                 855                 860                 


Pro Pro Pro Pro Phe Thr Ala Pro Met Glu Gly Lys Gly Ser Arg Pro 
865                 870                 875                 880 


Lys Asn Met Thr Pro Tyr Arg Ser Pro Pro Pro Tyr Val Pro Pro 
                885                 890                 895 


<210>  3946
<211>  895
<212>  PRT
<213>  Homo Sapiens

<400>  3946

Met Arg Met Ser Val Gly Leu Ser Leu Leu Leu Pro Leu Ser Gly Arg 
1               5                   10                  15      


Thr Phe Leu Leu Leu Leu Ser Val Val Met Ala Gln Ser His Trp Pro 
            20                  25                  30          


Ser Glu Pro Ser Glu Ala Val Arg Asp Trp Glu Asn Gln Leu Glu Ala 
        35                  40                  45              


Ser Met His Ser Val Leu Ser Asp Leu His Glu Ala Val Pro Thr Val 
    50                  55                  60                  


Val Gly Ile Pro Asp Gly Thr Ala Val Val Gly Arg Ser Phe Arg Val 
65                  70                  75                  80  


Thr Ile Pro Thr Asp Leu Ile Ala Ser Ser Gly Asp Ile Ile Lys Val 
                85                  90                  95      


Ser Ala Ala Gly Lys Glu Ala Leu Pro Ser Trp Leu His Trp Asp Ser 
            100                 105                 110         


Gln Ser His Thr Leu Glu Gly Leu Pro Leu Asp Thr Asp Lys Gly Val 
        115                 120                 125             


His Tyr Ile Ser Val Ser Ala Thr Arg Leu Gly Ala Asn Gly Ser His 
    130                 135                 140                 


Ile Pro Gln Thr Ser Ser Val Phe Ser Ile Glu Val Tyr Pro Glu Asp 
145                 150                 155                 160 


His Ser Glu Leu Gln Ser Val Arg Thr Ala Ser Pro Asp Pro Gly Glu 
                165                 170                 175     


Val Val Ser Ser Ala Cys Ala Ala Asp Glu Pro Val Thr Val Leu Thr 
            180                 185                 190         


Val Ile Leu Asp Ala Asp Leu Thr Lys Met Thr Pro Lys Gln Arg Ile 
        195                 200                 205             


Asp Leu Leu His Arg Met Arg Ser Phe Ser Glu Val Glu Leu His Asn 
    210                 215                 220                 


Met Lys Leu Val Pro Val Val Asn Asn Arg Leu Phe Asp Met Ser Ala 
225                 230                 235                 240 


Phe Met Ala Gly Pro Gly Asn Ala Lys Lys Val Val Glu Asn Gly Ala 
                245                 250                 255     


Leu Leu Ser Trp Lys Leu Gly Cys Ser Leu Asn Gln Asn Ser Val Pro 
            260                 265                 270         


Asp Ile His Gly Val Glu Ala Pro Ala Arg Glu Gly Ala Met Ser Ala 
        275                 280                 285             


Gln Leu Gly Tyr Pro Val Val Gly Trp His Ile Ala Asn Lys Lys Pro 
    290                 295                 300                 


Pro Leu Pro Lys Arg Val Arg Arg Gln Ile His Ala Thr Pro Thr Pro 
305                 310                 315                 320 


Val Thr Ala Ile Gly Pro Pro Thr Thr Ala Ile Gln Glu Pro Pro Ser 
                325                 330                 335     


Arg Ile Val Pro Thr Pro Thr Ser Pro Ala Ile Ala Pro Pro Thr Glu 
            340                 345                 350         


Thr Met Ala Pro Pro Val Arg Asp Pro Val Pro Gly Lys Pro Thr Val 
        355                 360                 365             


Thr Ile Arg Thr Arg Gly Ala Ile Ile Gln Thr Pro Thr Leu Gly Pro 
    370                 375                 380                 


Ile Gln Pro Thr Arg Val Ser Glu Ala Gly Thr Thr Val Pro Gly Gln 
385                 390                 395                 400 


Ile Arg Pro Thr Met Thr Ile Pro Gly Tyr Val Glu Pro Thr Ala Val 
                405                 410                 415     


Ala Thr Pro Pro Thr Thr Thr Thr Lys Lys Pro Arg Val Ser Thr Pro 
            420                 425                 430         


Lys Pro Ala Thr Pro Ser Thr Asp Ser Thr Thr Thr Thr Thr Arg Arg 
        435                 440                 445             


Pro Thr Lys Lys Pro Arg Thr Pro Arg Pro Val Pro Arg Val Thr Thr 
    450                 455                 460                 


Lys Val Ser Ile Thr Arg Leu Glu Thr Ala Ser Pro Pro Thr Arg Ile 
465                 470                 475                 480 


Arg Thr Thr Thr Ser Gly Val Pro Arg Gly Gly Glu Pro Asn Gln Arg 
                485                 490                 495     


Pro Glu Leu Lys Asn His Ile Asp Arg Val Asp Ala Trp Val Gly Thr 
            500                 505                 510         


Tyr Phe Glu Val Lys Ile Pro Ser Asp Thr Phe Tyr Asp His Glu Asp 
        515                 520                 525             


Thr Thr Thr Asp Lys Leu Lys Leu Thr Leu Lys Leu Arg Glu Gln Gln 
    530                 535                 540                 


Leu Val Gly Glu Lys Ser Trp Val Gln Phe Asn Ser Asn Ser Gln Leu 
545                 550                 555                 560 


Met Tyr Gly Leu Pro Asp Ser Ser His Val Gly Lys His Glu Tyr Phe 
                565                 570                 575     


Met His Ala Thr Asp Lys Gly Gly Leu Ser Ala Val Asp Ala Phe Glu 
            580                 585                 590         


Ile His Val His Arg Arg Pro Gln Gly Asp Arg Ala Pro Ala Arg Phe 
        595                 600                 605             


Lys Ala Lys Phe Val Gly Asp Pro Ala Leu Val Leu Asn Asp Ile His 
    610                 615                 620                 


Lys Lys Ile Ala Leu Val Lys Lys Leu Ala Phe Ala Phe Gly Asp Arg 
625                 630                 635                 640 


Asn Cys Ser Thr Ile Thr Leu Gln Asn Ile Thr Arg Gly Ser Ile Val 
                645                 650                 655     


Val Glu Trp Thr Asn Asn Thr Leu Pro Leu Glu Pro Cys Pro Lys Glu 
            660                 665                 670         


Gln Ile Ala Gly Leu Ser Arg Arg Ile Ala Glu Asp Asp Gly Lys Pro 
        675                 680                 685             


Arg Pro Ala Phe Ser Asn Ala Leu Glu Pro Asp Phe Lys Ala Thr Ser 
    690                 695                 700                 


Ile Thr Val Thr Gly Ser Gly Ser Cys Arg His Leu Gln Phe Ile Pro 
705                 710                 715                 720 


Val Val Pro Pro Arg Arg Val Pro Ser Glu Ala Pro Pro Thr Glu Val 
                725                 730                 735     


Pro Asp Arg Asp Pro Glu Lys Ser Ser Glu Asp Asp Val Tyr Leu His 
            740                 745                 750         


Thr Val Ile Pro Ala Val Val Val Ala Ala Ile Leu Leu Ile Ala Gly 
        755                 760                 765             


Ile Ile Ala Met Ile Cys Tyr Arg Lys Lys Arg Lys Gly Lys Leu Thr 
    770                 775                 780                 


Leu Glu Asp Gln Ala Thr Phe Ile Lys Lys Gly Val Pro Ile Ile Phe 
785                 790                 795                 800 


Ala Asp Glu Leu Asp Asp Ser Lys Pro Pro Pro Ser Ser Ser Met Pro 
                805                 810                 815     


Leu Ile Leu Gln Glu Glu Lys Ala Pro Leu Pro Pro Pro Glu Tyr Pro 
            820                 825                 830         


Asn Gln Ser Val Pro Glu Thr Thr Pro Leu Asn Gln Asp Thr Met Gly 
        835                 840                 845             


Glu Tyr Thr Pro Leu Arg Asp Glu Asp Pro Asn Ala Pro Pro Tyr Gln 
    850                 855                 860                 


Pro Pro Pro Pro Phe Thr Ala Pro Met Glu Gly Lys Gly Ser Arg Pro 
865                 870                 875                 880 


Lys Asn Met Thr Pro Tyr Arg Ser Pro Pro Pro Tyr Val Pro Pro 
                885                 890                 895 


<210>  3947
<211>  895
<212>  PRT
<213>  Homo Sapiens

<400>  3947

Met Arg Met Ser Val Gly Leu Ser Leu Leu Leu Pro Leu Ser Gly Arg 
1               5                   10                  15      


Thr Phe Leu Leu Leu Leu Ser Val Val Met Ala Gln Ser His Trp Pro 
            20                  25                  30          


Ser Glu Pro Ser Glu Ala Val Arg Asp Trp Glu Asn Gln Leu Glu Ala 
        35                  40                  45              


Ser Met His Ser Val Leu Ser Asp Leu His Glu Ala Val Pro Thr Val 
    50                  55                  60                  


Val Gly Ile Pro Asp Gly Thr Ala Val Val Gly Arg Ser Phe Arg Val 
65                  70                  75                  80  


Thr Ile Pro Thr Asp Leu Ile Ala Ser Ser Gly Asp Ile Ile Lys Val 
                85                  90                  95      


Ser Ala Ala Gly Lys Glu Ala Leu Pro Ser Trp Leu His Trp Asp Ser 
            100                 105                 110         


Gln Ser His Thr Leu Glu Gly Leu Pro Leu Asp Thr Asp Lys Gly Val 
        115                 120                 125             


His Tyr Ile Ser Val Ser Ala Thr Arg Leu Gly Ala Asn Gly Ser His 
    130                 135                 140                 


Ile Pro Gln Thr Ser Ser Val Phe Ser Ile Glu Val Tyr Pro Glu Asp 
145                 150                 155                 160 


His Ser Glu Leu Gln Ser Val Arg Thr Ala Ser Pro Asp Pro Gly Glu 
                165                 170                 175     


Val Val Ser Ser Ala Cys Ala Ala Asp Glu Pro Val Thr Val Leu Thr 
            180                 185                 190         


Val Ile Leu Asp Ala Asp Leu Thr Lys Met Thr Pro Lys Gln Arg Ile 
        195                 200                 205             


Asp Leu Leu His Arg Met Arg Ser Phe Ser Glu Val Glu Leu His Asn 
    210                 215                 220                 


Met Lys Leu Val Pro Val Val Asn Asn Arg Leu Phe Asp Met Ser Ala 
225                 230                 235                 240 


Phe Met Ala Gly Pro Gly Asn Ala Lys Lys Val Val Glu Asn Gly Ala 
                245                 250                 255     


Leu Leu Ser Trp Lys Leu Gly Cys Ser Leu Asn Gln Asn Ser Val Pro 
            260                 265                 270         


Asp Ile His Gly Val Glu Ala Pro Ala Arg Glu Gly Ala Met Ser Ala 
        275                 280                 285             


Gln Leu Gly Tyr Pro Val Val Gly Trp His Ile Ala Asn Lys Lys Pro 
    290                 295                 300                 


Pro Leu Pro Lys Arg Val Arg Arg Gln Ile His Ala Thr Pro Thr Pro 
305                 310                 315                 320 


Val Thr Ala Ile Gly Pro Pro Thr Thr Ala Ile Gln Glu Pro Pro Ser 
                325                 330                 335     


Arg Ile Val Pro Thr Pro Thr Ser Pro Ala Ile Ala Pro Pro Thr Glu 
            340                 345                 350         


Thr Met Ala Pro Pro Val Arg Asp Pro Val Pro Gly Lys Pro Thr Val 
        355                 360                 365             


Thr Ile Arg Thr Arg Gly Ala Ile Ile Gln Thr Pro Thr Leu Gly Pro 
    370                 375                 380                 


Ile Gln Pro Thr Arg Val Ser Glu Ala Gly Thr Thr Val Pro Gly Gln 
385                 390                 395                 400 


Ile Arg Pro Thr Met Thr Ile Pro Gly Tyr Val Glu Pro Thr Ala Val 
                405                 410                 415     


Ala Thr Pro Pro Thr Thr Thr Thr Lys Lys Pro Arg Val Ser Thr Pro 
            420                 425                 430         


Lys Pro Ala Thr Pro Ser Thr Asp Ser Thr Thr Thr Thr Thr Arg Arg 
        435                 440                 445             


Pro Thr Lys Lys Pro Arg Thr Pro Arg Pro Val Pro Arg Val Thr Thr 
    450                 455                 460                 


Lys Val Ser Ile Thr Arg Leu Glu Thr Ala Ser Pro Pro Thr Arg Ile 
465                 470                 475                 480 


Arg Thr Thr Thr Ser Gly Val Pro Arg Gly Gly Glu Pro Asn Gln Arg 
                485                 490                 495     


Pro Glu Leu Lys Asn His Ile Asp Arg Val Asp Ala Trp Val Gly Thr 
            500                 505                 510         


Tyr Phe Glu Val Lys Ile Pro Ser Asp Thr Phe Tyr Asp His Glu Asp 
        515                 520                 525             


Thr Thr Thr Asp Lys Leu Lys Leu Thr Leu Lys Leu Arg Glu Gln Gln 
    530                 535                 540                 


Leu Val Gly Glu Lys Ser Trp Val Gln Phe Asn Ser Asn Ser Gln Leu 
545                 550                 555                 560 


Met Tyr Gly Leu Pro Asp Ser Ser His Val Gly Lys His Glu Tyr Phe 
                565                 570                 575     


Met His Ala Thr Asp Lys Gly Gly Leu Ser Ala Val Asp Ala Phe Glu 
            580                 585                 590         


Ile His Val His Arg Arg Pro Gln Gly Asp Arg Ala Pro Ala Arg Phe 
        595                 600                 605             


Lys Ala Lys Phe Val Gly Asp Pro Ala Leu Val Leu Asn Asp Ile His 
    610                 615                 620                 


Lys Lys Ile Ala Leu Val Lys Lys Leu Ala Phe Ala Phe Gly Asp Arg 
625                 630                 635                 640 


Asn Cys Ser Thr Ile Thr Leu Gln Asn Ile Thr Arg Gly Ser Ile Val 
                645                 650                 655     


Val Glu Trp Thr Asn Asn Thr Leu Pro Leu Glu Pro Cys Pro Lys Glu 
            660                 665                 670         


Gln Ile Ala Gly Leu Ser Arg Arg Ile Ala Glu Asp Asp Gly Lys Pro 
        675                 680                 685             


Arg Pro Ala Phe Ser Asn Ala Leu Glu Pro Asp Phe Lys Ala Thr Ser 
    690                 695                 700                 


Ile Thr Val Thr Gly Ser Gly Ser Cys Arg His Leu Gln Phe Ile Pro 
705                 710                 715                 720 


Val Val Pro Pro Arg Arg Val Pro Ser Glu Ala Pro Pro Thr Glu Val 
                725                 730                 735     


Pro Asp Arg Asp Pro Glu Lys Ser Ser Glu Asp Asp Val Tyr Leu His 
            740                 745                 750         


Thr Val Ile Pro Ala Val Val Val Ala Ala Ile Leu Leu Ile Ala Gly 
        755                 760                 765             


Ile Ile Ala Met Ile Cys Tyr Arg Lys Lys Arg Lys Gly Lys Leu Thr 
    770                 775                 780                 


Leu Glu Asp Gln Ala Thr Phe Ile Lys Lys Gly Val Pro Ile Ile Phe 
785                 790                 795                 800 


Ala Asp Glu Leu Asp Asp Ser Lys Pro Pro Pro Ser Ser Ser Met Pro 
                805                 810                 815     


Leu Ile Leu Gln Glu Glu Lys Ala Pro Leu Pro Pro Pro Glu Tyr Pro 
            820                 825                 830         


Asn Gln Ser Val Pro Glu Thr Thr Pro Leu Asn Gln Asp Thr Met Gly 
        835                 840                 845             


Glu Tyr Thr Pro Leu Arg Asp Glu Asp Pro Asn Ala Pro Pro Tyr Gln 
    850                 855                 860                 


Pro Pro Pro Pro Phe Thr Ala Pro Met Glu Gly Lys Gly Ser Arg Pro 
865                 870                 875                 880 


Lys Asn Met Thr Pro Tyr Arg Ser Pro Pro Pro Tyr Val Pro Pro 
                885                 890                 895 


<210>  3948
<211>  895
<212>  PRT
<213>  Homo Sapiens

<400>  3948

Met Arg Met Ser Val Gly Leu Ser Leu Leu Leu Pro Leu Ser Gly Arg 
1               5                   10                  15      


Thr Phe Leu Leu Leu Leu Ser Val Val Met Ala Gln Ser His Trp Pro 
            20                  25                  30          


Ser Glu Pro Ser Glu Ala Val Arg Asp Trp Glu Asn Gln Leu Glu Ala 
        35                  40                  45              


Ser Met His Ser Val Leu Ser Asp Leu His Glu Ala Val Pro Thr Val 
    50                  55                  60                  


Val Gly Ile Pro Asp Gly Thr Ala Val Val Gly Arg Ser Phe Arg Val 
65                  70                  75                  80  


Thr Ile Pro Thr Asp Leu Ile Ala Ser Ser Gly Asp Ile Ile Lys Val 
                85                  90                  95      


Ser Ala Ala Gly Lys Glu Ala Leu Pro Ser Trp Leu His Trp Asp Ser 
            100                 105                 110         


Gln Ser His Thr Leu Glu Gly Leu Pro Leu Asp Thr Asp Lys Gly Val 
        115                 120                 125             


His Tyr Ile Ser Val Ser Ala Thr Arg Leu Gly Ala Asn Gly Ser His 
    130                 135                 140                 


Ile Pro Gln Thr Ser Ser Val Phe Ser Ile Glu Val Tyr Pro Glu Asp 
145                 150                 155                 160 


His Ser Glu Leu Gln Ser Val Arg Thr Ala Ser Pro Asp Pro Gly Glu 
                165                 170                 175     


Val Val Ser Ser Ala Cys Ala Ala Asp Glu Pro Val Thr Val Leu Thr 
            180                 185                 190         


Val Ile Leu Asp Ala Asp Leu Thr Lys Met Thr Pro Lys Gln Arg Ile 
        195                 200                 205             


Asp Leu Leu His Arg Met Arg Ser Phe Ser Glu Val Glu Leu His Asn 
    210                 215                 220                 


Met Lys Leu Val Pro Val Val Asn Asn Arg Leu Phe Asp Met Ser Ala 
225                 230                 235                 240 


Phe Met Ala Gly Pro Gly Asn Ala Lys Lys Val Val Glu Asn Gly Ala 
                245                 250                 255     


Leu Leu Ser Trp Lys Leu Gly Cys Ser Leu Asn Gln Asn Ser Val Pro 
            260                 265                 270         


Asp Ile His Gly Val Glu Ala Pro Ala Arg Glu Gly Ala Met Ser Ala 
        275                 280                 285             


Gln Leu Gly Tyr Pro Val Val Gly Trp His Ile Ala Asn Lys Lys Pro 
    290                 295                 300                 


Pro Leu Pro Lys Arg Val Arg Arg Gln Ile His Ala Thr Pro Thr Pro 
305                 310                 315                 320 


Val Thr Ala Ile Gly Pro Pro Thr Thr Ala Ile Gln Glu Pro Pro Ser 
                325                 330                 335     


Arg Ile Val Pro Thr Pro Thr Ser Pro Ala Ile Ala Pro Pro Thr Glu 
            340                 345                 350         


Thr Met Ala Pro Pro Val Arg Asp Pro Val Pro Gly Lys Pro Thr Val 
        355                 360                 365             


Thr Ile Arg Thr Arg Gly Ala Ile Ile Gln Thr Pro Thr Leu Gly Pro 
    370                 375                 380                 


Ile Gln Pro Thr Arg Val Ser Glu Ala Gly Thr Thr Val Pro Gly Gln 
385                 390                 395                 400 


Ile Arg Pro Thr Met Thr Ile Pro Gly Tyr Val Glu Pro Thr Ala Val 
                405                 410                 415     


Ala Thr Pro Pro Thr Thr Thr Thr Lys Lys Pro Arg Val Ser Thr Pro 
            420                 425                 430         


Lys Pro Ala Thr Pro Ser Thr Asp Ser Thr Thr Thr Thr Thr Arg Arg 
        435                 440                 445             


Pro Thr Lys Lys Pro Arg Thr Pro Arg Pro Val Pro Arg Val Thr Thr 
    450                 455                 460                 


Lys Val Ser Ile Thr Arg Leu Glu Thr Ala Ser Pro Pro Thr Arg Ile 
465                 470                 475                 480 


Arg Thr Thr Thr Ser Gly Val Pro Arg Gly Gly Glu Pro Asn Gln Arg 
                485                 490                 495     


Pro Glu Leu Lys Asn His Ile Asp Arg Val Asp Ala Trp Val Gly Thr 
            500                 505                 510         


Tyr Phe Glu Val Lys Ile Pro Ser Asp Thr Phe Tyr Asp His Glu Asp 
        515                 520                 525             


Thr Thr Thr Asp Lys Leu Lys Leu Thr Leu Lys Leu Arg Glu Gln Gln 
    530                 535                 540                 


Leu Val Gly Glu Lys Ser Trp Val Gln Phe Asn Ser Asn Ser Gln Leu 
545                 550                 555                 560 


Met Tyr Gly Leu Pro Asp Ser Ser His Val Gly Lys His Glu Tyr Phe 
                565                 570                 575     


Met His Ala Thr Asp Lys Gly Gly Leu Ser Ala Val Asp Ala Phe Glu 
            580                 585                 590         


Ile His Val His Arg Arg Pro Gln Gly Asp Arg Ala Pro Ala Arg Phe 
        595                 600                 605             


Lys Ala Lys Phe Val Gly Asp Pro Ala Leu Val Leu Asn Asp Ile His 
    610                 615                 620                 


Lys Lys Ile Ala Leu Val Lys Lys Leu Ala Phe Ala Phe Gly Asp Arg 
625                 630                 635                 640 


Asn Cys Ser Thr Ile Thr Leu Gln Asn Ile Thr Arg Gly Ser Ile Val 
                645                 650                 655     


Val Glu Trp Thr Asn Asn Thr Leu Pro Leu Glu Pro Cys Pro Lys Glu 
            660                 665                 670         


Gln Ile Ala Gly Leu Ser Arg Arg Ile Ala Glu Asp Asp Gly Lys Pro 
        675                 680                 685             


Arg Pro Ala Phe Ser Asn Ala Leu Glu Pro Asp Phe Lys Ala Thr Ser 
    690                 695                 700                 


Ile Thr Val Thr Gly Ser Gly Ser Cys Arg His Leu Gln Phe Ile Pro 
705                 710                 715                 720 


Val Val Pro Pro Arg Arg Val Pro Ser Glu Ala Pro Pro Thr Glu Val 
                725                 730                 735     


Pro Asp Arg Asp Pro Glu Lys Ser Ser Glu Asp Asp Val Tyr Leu His 
            740                 745                 750         


Thr Val Ile Pro Ala Val Val Val Ala Ala Ile Leu Leu Ile Ala Gly 
        755                 760                 765             


Ile Ile Ala Met Ile Cys Tyr Arg Lys Lys Arg Lys Gly Lys Leu Thr 
    770                 775                 780                 


Leu Glu Asp Gln Ala Thr Phe Ile Lys Lys Gly Val Pro Ile Ile Phe 
785                 790                 795                 800 


Ala Asp Glu Leu Asp Asp Ser Lys Pro Pro Pro Ser Ser Ser Met Pro 
                805                 810                 815     


Leu Ile Leu Gln Glu Glu Lys Ala Pro Leu Pro Pro Pro Glu Tyr Pro 
            820                 825                 830         


Asn Gln Ser Val Pro Glu Thr Thr Pro Leu Asn Gln Asp Thr Met Gly 
        835                 840                 845             


Glu Tyr Thr Pro Leu Arg Asp Glu Asp Pro Asn Ala Pro Pro Tyr Gln 
    850                 855                 860                 


Pro Pro Pro Pro Phe Thr Ala Pro Met Glu Gly Lys Gly Ser Arg Pro 
865                 870                 875                 880 


Lys Asn Met Thr Pro Tyr Arg Ser Pro Pro Pro Tyr Val Pro Pro 
                885                 890                 895 


<210>  3949
<211>  895
<212>  PRT
<213>  Homo Sapiens

<400>  3949

Met Arg Met Ser Val Gly Leu Ser Leu Leu Leu Pro Leu Ser Gly Arg 
1               5                   10                  15      


Thr Phe Leu Leu Leu Leu Ser Val Val Met Ala Gln Ser His Trp Pro 
            20                  25                  30          


Ser Glu Pro Ser Glu Ala Val Arg Asp Trp Glu Asn Gln Leu Glu Ala 
        35                  40                  45              


Ser Met His Ser Val Leu Ser Asp Leu His Glu Ala Val Pro Thr Val 
    50                  55                  60                  


Val Gly Ile Pro Asp Gly Thr Ala Val Val Gly Arg Ser Phe Arg Val 
65                  70                  75                  80  


Thr Ile Pro Thr Asp Leu Ile Ala Ser Ser Gly Asp Ile Ile Lys Val 
                85                  90                  95      


Ser Ala Ala Gly Lys Glu Ala Leu Pro Ser Trp Leu His Trp Asp Ser 
            100                 105                 110         


Gln Ser His Thr Leu Glu Gly Leu Pro Leu Asp Thr Asp Lys Gly Val 
        115                 120                 125             


His Tyr Ile Ser Val Ser Ala Thr Arg Leu Gly Ala Asn Gly Ser His 
    130                 135                 140                 


Ile Pro Gln Thr Ser Ser Val Phe Ser Ile Glu Val Tyr Pro Glu Asp 
145                 150                 155                 160 


His Ser Glu Leu Gln Ser Val Arg Thr Ala Ser Pro Asp Pro Gly Glu 
                165                 170                 175     


Val Val Ser Ser Ala Cys Ala Ala Asp Glu Pro Val Thr Val Leu Thr 
            180                 185                 190         


Val Ile Leu Asp Ala Asp Leu Thr Lys Met Thr Pro Lys Gln Arg Ile 
        195                 200                 205             


Asp Leu Leu His Arg Met Arg Ser Phe Ser Glu Val Glu Leu His Asn 
    210                 215                 220                 


Met Lys Leu Val Pro Val Val Asn Asn Arg Leu Phe Asp Met Ser Ala 
225                 230                 235                 240 


Phe Met Ala Gly Pro Gly Asn Ala Lys Lys Val Val Glu Asn Gly Ala 
                245                 250                 255     


Leu Leu Ser Trp Lys Leu Gly Cys Ser Leu Asn Gln Asn Ser Val Pro 
            260                 265                 270         


Asp Ile His Gly Val Glu Ala Pro Ala Arg Glu Gly Ala Met Ser Ala 
        275                 280                 285             


Gln Leu Gly Tyr Pro Val Val Gly Trp His Ile Ala Asn Lys Lys Pro 
    290                 295                 300                 


Pro Leu Pro Lys Arg Val Arg Arg Gln Ile His Ala Thr Pro Thr Pro 
305                 310                 315                 320 


Val Thr Ala Ile Gly Pro Pro Thr Thr Ala Ile Gln Glu Pro Pro Ser 
                325                 330                 335     


Arg Ile Val Pro Thr Pro Thr Ser Pro Ala Ile Ala Pro Pro Thr Glu 
            340                 345                 350         


Thr Met Ala Pro Pro Val Arg Asp Pro Val Pro Gly Lys Pro Thr Val 
        355                 360                 365             


Thr Ile Arg Thr Arg Gly Ala Ile Ile Gln Thr Pro Thr Leu Gly Pro 
    370                 375                 380                 


Ile Gln Pro Thr Arg Val Ser Glu Ala Gly Thr Thr Val Pro Gly Gln 
385                 390                 395                 400 


Ile Arg Pro Thr Met Thr Ile Pro Gly Tyr Val Glu Pro Thr Ala Val 
                405                 410                 415     


Ala Thr Pro Pro Thr Thr Thr Thr Lys Lys Pro Arg Val Ser Thr Pro 
            420                 425                 430         


Lys Pro Ala Thr Pro Ser Thr Asp Ser Thr Thr Thr Thr Thr Arg Arg 
        435                 440                 445             


Pro Thr Lys Lys Pro Arg Thr Pro Arg Pro Val Pro Arg Val Thr Thr 
    450                 455                 460                 


Lys Val Ser Ile Thr Arg Leu Glu Thr Ala Ser Pro Pro Thr Arg Ile 
465                 470                 475                 480 


Arg Thr Thr Thr Ser Gly Val Pro Arg Gly Gly Glu Pro Asn Gln Arg 
                485                 490                 495     


Pro Glu Leu Lys Asn His Ile Asp Arg Val Asp Ala Trp Val Gly Thr 
            500                 505                 510         


Tyr Phe Glu Val Lys Ile Pro Ser Asp Thr Phe Tyr Asp His Glu Asp 
        515                 520                 525             


Thr Thr Thr Asp Lys Leu Lys Leu Thr Leu Lys Leu Arg Glu Gln Gln 
    530                 535                 540                 


Leu Val Gly Glu Lys Ser Trp Val Gln Phe Asn Ser Asn Ser Gln Leu 
545                 550                 555                 560 


Met Tyr Gly Leu Pro Asp Ser Ser His Val Gly Lys His Glu Tyr Phe 
                565                 570                 575     


Met His Ala Thr Asp Lys Gly Gly Leu Ser Ala Val Asp Ala Phe Glu 
            580                 585                 590         


Ile His Val His Arg Arg Pro Gln Gly Asp Arg Ala Pro Ala Arg Phe 
        595                 600                 605             


Lys Ala Lys Phe Val Gly Asp Pro Ala Leu Val Leu Asn Asp Ile His 
    610                 615                 620                 


Lys Lys Ile Ala Leu Val Lys Lys Leu Ala Phe Ala Phe Gly Asp Arg 
625                 630                 635                 640 


Asn Cys Ser Thr Ile Thr Leu Gln Asn Ile Thr Arg Gly Ser Ile Val 
                645                 650                 655     


Val Glu Trp Thr Asn Asn Thr Leu Pro Leu Glu Pro Cys Pro Lys Glu 
            660                 665                 670         


Gln Ile Ala Gly Leu Ser Arg Arg Ile Ala Glu Asp Asp Gly Lys Pro 
        675                 680                 685             


Arg Pro Ala Phe Ser Asn Ala Leu Glu Pro Asp Phe Lys Ala Thr Ser 
    690                 695                 700                 


Ile Thr Val Thr Gly Ser Gly Ser Cys Arg His Leu Gln Phe Ile Pro 
705                 710                 715                 720 


Val Val Pro Pro Arg Arg Val Pro Ser Glu Ala Pro Pro Thr Glu Val 
                725                 730                 735     


Pro Asp Arg Asp Pro Glu Lys Ser Ser Glu Asp Asp Val Tyr Leu His 
            740                 745                 750         


Thr Val Ile Pro Ala Val Val Val Ala Ala Ile Leu Leu Ile Ala Gly 
        755                 760                 765             


Ile Ile Ala Met Ile Cys Tyr Arg Lys Lys Arg Lys Gly Lys Leu Thr 
    770                 775                 780                 


Leu Glu Asp Gln Ala Thr Phe Ile Lys Lys Gly Val Pro Ile Ile Phe 
785                 790                 795                 800 


Ala Asp Glu Leu Asp Asp Ser Lys Pro Pro Pro Ser Ser Ser Met Pro 
                805                 810                 815     


Leu Ile Leu Gln Glu Glu Lys Ala Pro Leu Pro Pro Pro Glu Tyr Pro 
            820                 825                 830         


Asn Gln Ser Val Pro Glu Thr Thr Pro Leu Asn Gln Asp Thr Met Gly 
        835                 840                 845             


Glu Tyr Thr Pro Leu Arg Asp Glu Asp Pro Asn Ala Pro Pro Tyr Gln 
    850                 855                 860                 


Pro Pro Pro Pro Phe Thr Ala Pro Met Glu Gly Lys Gly Ser Arg Pro 
865                 870                 875                 880 


Lys Asn Met Thr Pro Tyr Arg Ser Pro Pro Pro Tyr Val Pro Pro 
                885                 890                 895 


<210>  3950
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  3950

Met Leu Leu Gly Gln Leu Ser Thr Leu Leu Cys Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Pro Thr Gly Ser Gly Arg Pro Glu Pro Gln Ser Pro Arg Pro Gln 
            20                  25                  30          


Ser Trp Ala Ala Ala Asn Gln Thr Trp Ala Leu Gly Pro Gly Ala Leu 
        35                  40                  45              


Pro Pro Leu Val Pro Ala Ser Ala Leu Gly Ser Trp Lys Ala Phe Leu 
    50                  55                  60                  


Gly Leu Gln Lys Ala Arg Gln Leu Gly Met Gly Arg Leu Gln Arg Gly 
65                  70                  75                  80  


Gln Asp Glu Val Ala Ala Val Thr Leu Pro Leu Asn Pro Gln Glu Val 
                85                  90                  95      


Ile Gln Gly Met Cys Lys Ala Val Pro Phe Val Gln Val Phe Ser Arg 
            100                 105                 110         


Pro Gly Cys Ser Ala Ile Arg Leu Arg Asn His Leu Cys Phe Gly His 
        115                 120                 125             


Cys Ser Ser Leu Tyr Ile Pro Gly Ser Asp Pro Thr Pro Leu Val Leu 
    130                 135                 140                 


Cys Asn Ser Cys Met Pro Ala Arg Lys Arg Trp Ala Pro Val Val Leu 
145                 150                 155                 160 


Trp Cys Leu Thr Gly Ser Ser Ala Ser Arg Arg Arg Val Lys Ile Ser 
                165                 170                 175     


Thr Met Leu Ile Glu Gly Cys His Cys Ser Pro Lys Ala 
            180                 185                 


<210>  3951
<211>  163
<212>  PRT
<213>  Homo Sapiens

<400>  3951

Met Pro Leu Thr Arg Gln Gln Gly Arg Leu Leu Val Thr Leu Ser Pro 
1               5                   10                  15      


Val Arg Thr Asp Arg Gln Ala Asp Arg Arg Thr Asp Lys Gln Met Leu 
            20                  25                  30          


Leu Gly Gln Leu Ser Thr Leu Leu Cys Leu Leu Ser Gly Ala Leu Pro 
        35                  40                  45              


Thr Gly Ser Gly Arg Pro Glu Pro Gln Ser Pro Arg Pro Gln Ser Trp 
    50                  55                  60                  


Ala Ala Ala Asn Gln Thr Trp Ala Leu Gly Pro Gly Ala Leu Pro Pro 
65                  70                  75                  80  


Leu Val Pro Ala Ser Ala Leu Gly Ser Trp Lys Ala Phe Leu Gly Leu 
                85                  90                  95      


Gln Lys Ala Arg Gln Leu Gly Met Gly Arg Leu Gln Arg Gly Gln Asp 
            100                 105                 110         


Glu Val Ala Ala Val Thr Leu Pro Leu Asn Pro Gln Glu Val Ile Gln 
        115                 120                 125             


Gly Met Cys Lys Ala Val Pro Phe Val Gln Thr Arg Glu Ser Arg Tyr 
    130                 135                 140                 


Val Ala Gln Ala Ser Leu Glu Leu Leu Ala Ser Ser Asn Pro Pro Thr 
145                 150                 155                 160 


Ser Ala Ser 
            


<210>  3952
<211>  167
<212>  PRT
<213>  Homo Sapiens

<400>  3952

Met Phe Pro Asp Tyr Gly Tyr Gly Trp Phe His Thr Ser Leu Ile Leu 
1               5                   10                  15      


Glu Gly Lys Asn Tyr Leu Gln Trp Leu Thr Glu Arg Leu Thr Glu Arg 
            20                  25                  30          


Gly Val Lys Phe Phe Gln Arg Lys Val Glu Ser Phe Glu Glu Val Ala 
        35                  40                  45              


Arg Glu Gly Ala Asp Val Ile Val Asn Cys Thr Gly Val Trp Ala Gly 
    50                  55                  60                  


Ala Leu Gln Arg Asp Pro Leu Leu Gln Pro Gly Arg Gly Gln Ile Met 
65                  70                  75                  80  


Lys Val Asp Ala Pro Trp Met Lys His Phe Ile Leu Thr His Asp Pro 
                85                  90                  95      


Glu Arg Gly Ile Tyr Asn Ser Pro Tyr Ile Ile Pro Gly Thr Gln Thr 
            100                 105                 110         


Val Thr Leu Gly Gly Ile Phe Gln Leu Gly Asn Trp Ser Glu Leu Asn 
        115                 120                 125             


Asn Ile Gln Asp His Asn Thr Ile Trp Glu Gly Cys Cys Arg Leu Glu 
    130                 135                 140                 


Pro Thr Leu Lys Asn Ala Arg Ile Ile Gly Glu Arg Thr Gly Phe Arg 
145                 150                 155                 160 


Pro Val Arg Pro Gln Ile Arg 
                165         


<210>  3953
<211>  197
<212>  PRT
<213>  Homo Sapiens

<400>  3953

Met Arg Val Val Val Ile Gly Ala Gly Val Ile Gly Leu Ser Thr Ala 
1               5                   10                  15      


Leu Cys Ile His Glu Arg Tyr His Ser Val Leu Gln Pro Leu Asp Ile 
            20                  25                  30          


Lys Val Tyr Ala Asp Arg Phe Thr Pro Leu Thr Thr Thr Asp Val Ala 
        35                  40                  45              


Ala Gly Leu Trp Gln Pro Tyr Leu Ser Asp Pro Asn Asn Pro Gln Glu 
    50                  55                  60                  


Ala Asp Trp Ser Gln Gln Thr Phe Asp Tyr Leu Leu Ser His Val His 
65                  70                  75                  80  


Ser Pro Asn Ala Glu Asn Leu Gly Leu Phe Leu Ile Ser Gly Tyr Asn 
                85                  90                  95      


Leu Phe His Glu Ala Ile Pro Asp Pro Ser Trp Lys Asp Thr Val Leu 
            100                 105                 110         


Gly Phe Arg Lys Leu Thr Pro Arg Glu Leu Asp Met Phe Pro Asp Tyr 
        115                 120                 125             


Gly Tyr Gly Trp Phe His Thr Ser Leu Ile Leu Glu Gly Lys Asn Tyr 
    130                 135                 140                 


Leu Gln Trp Leu Thr Glu Arg Leu Thr Glu Arg Gly Val Lys Phe Phe 
145                 150                 155                 160 


Gln Arg Lys Val Glu Ser Phe Glu Glu Val Ala Arg Glu Gly Ala Asp 
                165                 170                 175     


Val Ile Val Asn Cys Thr Gly Val Trp Ala Gly Ala Leu Gln Arg Asp 
            180                 185                 190         


Pro Leu Leu Gln Pro 
        195         


<210>  3954
<211>  347
<212>  PRT
<213>  Homo Sapiens

<400>  3954

Met Arg Val Val Val Ile Gly Ala Gly Val Ile Gly Leu Ser Thr Ala 
1               5                   10                  15      


Leu Cys Ile His Glu Arg Tyr His Ser Val Leu Gln Pro Leu Asp Ile 
            20                  25                  30          


Lys Val Tyr Ala Asp Arg Phe Thr Pro Leu Thr Thr Thr Asp Val Ala 
        35                  40                  45              


Ala Gly Leu Trp Gln Pro Tyr Leu Ser Asp Pro Asn Asn Pro Gln Glu 
    50                  55                  60                  


Ala Asp Trp Ser Gln Gln Thr Phe Asp Tyr Leu Leu Ser His Val His 
65                  70                  75                  80  


Ser Pro Asn Ala Glu Asn Leu Gly Leu Phe Leu Ile Ser Gly Tyr Asn 
                85                  90                  95      


Leu Phe His Glu Ala Ile Pro Asp Pro Ser Trp Lys Asp Thr Val Leu 
            100                 105                 110         


Gly Phe Arg Lys Leu Thr Pro Arg Glu Leu Asp Met Phe Pro Asp Tyr 
        115                 120                 125             


Gly Tyr Gly Trp Phe His Thr Ser Leu Ile Leu Glu Gly Lys Asn Tyr 
    130                 135                 140                 


Leu Gln Trp Leu Thr Glu Arg Leu Thr Glu Arg Gly Val Lys Phe Phe 
145                 150                 155                 160 


Gln Arg Lys Val Glu Ser Phe Glu Glu Val Ala Arg Glu Gly Ala Asp 
                165                 170                 175     


Val Ile Val Asn Cys Thr Gly Val Trp Ala Gly Ala Leu Gln Arg Asp 
            180                 185                 190         


Pro Leu Leu Gln Pro Gly Arg Gly Gln Ile Met Lys Val Asp Ala Pro 
        195                 200                 205             


Trp Met Lys His Phe Ile Leu Thr His Asp Pro Glu Arg Gly Ile Tyr 
    210                 215                 220                 


Asn Ser Pro Tyr Ile Ile Pro Gly Thr Gln Thr Val Thr Leu Gly Gly 
225                 230                 235                 240 


Ile Phe Gln Leu Gly Asn Trp Ser Glu Leu Asn Asn Ile Gln Asp His 
                245                 250                 255     


Asn Thr Ile Trp Glu Gly Cys Cys Arg Leu Glu Pro Thr Leu Lys Asn 
            260                 265                 270         


Ala Arg Ile Ile Gly Glu Arg Thr Gly Phe Arg Pro Val Arg Pro Gln 
        275                 280                 285             


Ile Arg Leu Glu Arg Glu Gln Leu Arg Thr Gly Pro Ser Asn Thr Glu 
    290                 295                 300                 


Val Ile His Asn Tyr Gly His Gly Gly Tyr Gly Leu Thr Ile His Trp 
305                 310                 315                 320 


Gly Cys Ala Leu Glu Ala Ala Lys Leu Phe Gly Arg Ile Leu Glu Glu 
                325                 330                 335     


Lys Lys Leu Ser Arg Met Pro Pro Ser His Leu 
            340                 345         


<210>  3955
<211>  123
<212>  PRT
<213>  Homo Sapiens

<400>  3955

Met Arg Val Val Val Ile Gly Ala Gly Val Ile Gly Leu Ser Thr Ala 
1               5                   10                  15      


Leu Cys Ile His Glu Arg Tyr His Ser Val Leu Gln Pro Leu Asp Ile 
            20                  25                  30          


Lys Val Tyr Ala Asp Arg Phe Thr Pro Leu Thr Thr Thr Asp Val Ala 
        35                  40                  45              


Ala Gly Leu Trp Gln Pro Tyr Leu Ser Asp Pro Asn Asn Pro Gln Glu 
    50                  55                  60                  


Ala Asp Trp Ser Gln Gln Thr Phe Asp Tyr Leu Leu Ser His Val His 
65                  70                  75                  80  


Ser Pro Asn Ala Glu Asn Leu Gly Leu Phe Leu Ile Ser Gly Tyr Asn 
                85                  90                  95      


Leu Phe His Glu Ala Ile Pro Leu Trp Leu Val Pro His Lys Pro Asn 
            100                 105                 110         


Ser Gly Gly Lys Glu Leu Ser Thr Val Ala Asp 
        115                 120             


<210>  3956
<211>  281
<212>  PRT
<213>  Homo Sapiens

<400>  3956

Met Arg Val Val Val Ile Gly Ala Gly Val Ile Gly Leu Ser Thr Ala 
1               5                   10                  15      


Leu Cys Ile His Glu Arg Tyr His Ser Val Leu Gln Pro Leu Asp Ile 
            20                  25                  30          


Lys Val Tyr Ala Asp Arg Phe Thr Pro Leu Thr Thr Thr Asp Val Ala 
        35                  40                  45              


Ala Gly Leu Trp Gln Pro Tyr Leu Ser Asp Pro Asn Asn Pro Gln Glu 
    50                  55                  60                  


Ala Asp Trp Ser Gln Gln Thr Phe Asp Tyr Leu Leu Ser His Val His 
65                  70                  75                  80  


Ser Pro Asn Ala Glu Asn Leu Gly Leu Phe Leu Ile Ser Gly Tyr Asn 
                85                  90                  95      


Leu Phe His Glu Ala Ile Pro Val Ala Arg Glu Gly Ala Asp Val Ile 
            100                 105                 110         


Val Asn Cys Thr Gly Val Trp Ala Gly Ala Leu Gln Arg Asp Pro Leu 
        115                 120                 125             


Leu Gln Pro Gly Arg Gly Gln Ile Met Lys Val Asp Ala Pro Trp Met 
    130                 135                 140                 


Lys His Phe Ile Leu Thr His Asp Pro Glu Arg Gly Ile Tyr Asn Ser 
145                 150                 155                 160 


Pro Tyr Ile Ile Pro Gly Thr Gln Thr Val Thr Leu Gly Gly Ile Phe 
                165                 170                 175     


Gln Leu Gly Asn Trp Ser Glu Leu Asn Asn Ile Gln Asp His Asn Thr 
            180                 185                 190         


Ile Trp Glu Gly Cys Cys Arg Leu Glu Pro Thr Leu Lys Asn Ala Arg 
        195                 200                 205             


Ile Ile Gly Glu Arg Thr Gly Phe Arg Pro Val Arg Pro Gln Ile Arg 
    210                 215                 220                 


Leu Glu Arg Glu Gln Leu Arg Thr Gly Pro Ser Asn Thr Glu Val Ile 
225                 230                 235                 240 


His Asn Tyr Gly His Gly Gly Tyr Gly Leu Thr Ile His Trp Gly Cys 
                245                 250                 255     


Ala Leu Glu Ala Ala Lys Leu Phe Gly Arg Ile Leu Glu Glu Lys Lys 
            260                 265                 270         


Leu Ser Arg Met Pro Pro Ser His Leu 
        275                 280     


<210>  3957
<211>  78
<212>  PRT
<213>  Homo Sapiens

<400>  3957

Met Arg Val Val Val Ile Gly Ala Gly Val Ile Gly Leu Ser Thr Ala 
1               5                   10                  15      


Leu Cys Ile His Glu Arg Tyr His Ser Val Leu Gln Pro Leu Asp Ile 
            20                  25                  30          


Lys Val Tyr Ala Asp Arg Phe Thr Pro Leu Thr Thr Thr Asp Val Ala 
        35                  40                  45              


Ala Gly Leu Trp Gln Pro Tyr Leu Ser Asp Pro Asn Asn Pro Gln Glu 
    50                  55                  60                  


Ala Thr Leu Pro Gly Arg Thr Gln Phe Trp Asp Phe Gly Ser 
65                  70                  75              


<210>  3958
<211>  73
<212>  PRT
<213>  Homo Sapiens

<400>  3958

Met Asn Ser Lys Gly Gln Tyr Pro Thr Gln Pro Thr Tyr Pro Val Gln 
1               5                   10                  15      


Pro Pro Gly Asn Pro Val Tyr Pro Gln Thr Leu His Leu Pro Gln Ala 
            20                  25                  30          


Pro Pro Tyr Thr Asp Ala Pro Pro Ala Tyr Ser Glu Gly Leu Pro Gln 
        35                  40                  45              


Ser Pro Pro Cys Gln Pro His Phe Leu Glu Pro Leu Cys Ile Phe Pro 
    50                  55                  60                  


Trp Pro Ser Leu Trp Leu Leu Gly Leu 
65                  70              


<210>  3959
<211>  207
<212>  PRT
<213>  Homo Sapiens

<400>  3959

Met Asn Ser Lys Gly Gln Tyr Pro Thr Gln Pro Thr Tyr Pro Val Gln 
1               5                   10                  15      


Pro Pro Gly Asn Pro Val Tyr Pro Gln Thr Leu His Leu Pro Gln Ala 
            20                  25                  30          


Pro Pro Tyr Thr Asp Ala Pro Pro Ala Tyr Ser Glu Leu Tyr Arg Pro 
        35                  40                  45              


Ser Phe Val His Pro Gly Ala Ala Thr Val Pro Thr Met Ser Ala Ala 
    50                  55                  60                  


Phe Pro Gly Ala Ser Leu Tyr Leu Pro Met Ala Gln Ser Val Ala Val 
65                  70                  75                  80  


Gly Pro Leu Gly Ser Thr Ile Pro Met Ala Tyr Tyr Pro Val Gly Pro 
                85                  90                  95      


Ile Tyr Pro Pro Ala Ser Thr Ser Trp Met Pro Ser Gln Cys Cys Ser 
            100                 105                 110         


Ala Cys Ser His Ala Gly Ser Gln Arg Pro Arg Asn Ser Ala Glu Gly 
        115                 120                 125             


Glu Leu Leu His Gly Trp Phe Arg Trp Trp Leu His His Leu Val Arg 
    130                 135                 140                 


Asn Gln Gly His Leu Cys Ala Gly Lys Asp Ile Thr Tyr Leu Gln His 
145                 150                 155                 160 


Phe Ser Gln Cys Asn Cys Phe Ser His Ile Asn Leu Lys Leu Gln Phe 
                165                 170                 175     


Arg His Met Leu Leu Gly Cys Leu Ser Gly Ala Gln Thr Phe Arg His 
            180                 185                 190         


Phe Ser Asn Leu Ile Arg Asn His Val Met Val Ala Val Pro Pro 
        195                 200                 205         


<210>  3960
<211>  168
<212>  PRT
<213>  Homo Sapiens

<400>  3960

Met Asn Ser Lys Gly Gln Tyr Pro Thr Gln Pro Thr Tyr Pro Val Gln 
1               5                   10                  15      


Pro Pro Gly Asn Pro Val Tyr Pro Gln Thr Leu His Leu Pro Gln Ala 
            20                  25                  30          


Pro Pro Tyr Thr Asp Ala Pro Pro Ala Tyr Ser Glu Leu Tyr Arg Pro 
        35                  40                  45              


Ser Phe Val His Pro Gly Ala Ala Thr Val Pro Thr Met Ser Ala Ala 
    50                  55                  60                  


Phe Pro Gly Ala Ser Leu Tyr Leu Pro Met Ala Gln Ser Val Ala Val 
65                  70                  75                  80  


Gly Pro Leu Gly Ser Thr Ile Pro Met Ala Tyr Tyr Pro Val Gly Pro 
                85                  90                  95      


Ile Tyr Pro Pro Gly Ser Thr Val Leu Val Glu Gly Gly Tyr Asp Ala 
            100                 105                 110         


Gly Ala Arg Phe Gly Ala Gly Ala Thr Ala Gly Asn Ile Pro Pro Pro 
        115                 120                 125             


Pro Pro Gly Cys Pro Pro Asn Ala Ala Gln Leu Ala Val Met Gln Gly 
    130                 135                 140                 


Ala Asn Val Leu Val Thr Gln Arg Lys Gly Asn Phe Phe Met Gly Gly 
145                 150                 155                 160 


Ser Asp Gly Gly Tyr Thr Ile Trp 
                165             


<210>  3961
<211>  134
<212>  PRT
<213>  Homo Sapiens

<400>  3961

Met Asn Ser Lys Gly Gln Tyr Pro Thr Gln Pro Thr Tyr Pro Val Gln 
1               5                   10                  15      


Pro Pro Gly Asn Pro Val Tyr Pro Gln Thr Leu His Leu Pro Gln Ala 
            20                  25                  30          


Pro Pro Tyr Thr Asp Ala Pro Pro Ala Tyr Ser Glu Leu Tyr Arg Pro 
        35                  40                  45              


Ser Phe Val His Pro Gly Ala Ala Thr Val Pro Thr Met Ser Ala Ala 
    50                  55                  60                  


Phe Pro Gly Ala Ser Leu Tyr Leu Pro Met Ala Gln Ser Val Ala Val 
65                  70                  75                  80  


Gly Pro Leu Gly Ser Thr Ile Pro Met Ala Tyr Tyr Pro Val Gly Pro 
                85                  90                  95      


Ile Tyr Pro Pro Gly Ser Thr Val Leu Val Glu Gly Gly Tyr Asp Ala 
            100                 105                 110         


Gly Ala Arg Phe Gly Ala Gly Ala Thr Ala Gly Asn Ile Pro Val Cys 
        115                 120                 125             


Val Leu Lys Leu Gly Arg 
    130                 


<210>  3962
<211>  153
<212>  PRT
<213>  Homo Sapiens

<400>  3962

Met Asn Ser Lys Gly Gln Tyr Pro Thr Gln Pro Thr Tyr Pro Val Gln 
1               5                   10                  15      


Pro Pro Gly Asn Pro Val Tyr Pro Gln Thr Leu His Leu Pro Gln Ala 
            20                  25                  30          


Pro Pro Tyr Thr Asp Ala Pro Pro Ala Tyr Ser Glu Leu Tyr Arg Pro 
        35                  40                  45              


Ser Phe Val His Pro Gly Ala Ala Thr Val Pro Thr Met Ser Ala Ala 
    50                  55                  60                  


Phe Pro Gly Ala Ser Leu Tyr Leu Pro Met Ala Gln Ser Val Ala Val 
65                  70                  75                  80  


Gly Pro Leu Gly Ser Thr Ile Pro Met Ala Tyr Tyr Pro Val Gly Pro 
                85                  90                  95      


Ile Tyr Pro Pro Gly Ser Thr Val Leu Val Glu Gly Gly Tyr Asp Ala 
            100                 105                 110         


Gly Ala Arg Phe Gly Ala Gly Ala Thr Ala Gly Asn Ile Pro Val Lys 
        115                 120                 125             


Glu Asp Gln Asp His Asp Arg Glu Gln Gly Glu Glu Asp Asn Gly Asp 
    130                 135                 140                 


Asn Asn Leu Glu Arg Arg Gly Lys Met 
145                 150             


<210>  3963
<211>  146
<212>  PRT
<213>  Homo Sapiens

<400>  3963

Met Asn Ser Lys Gly Gln Tyr Pro Thr Gln Pro Thr Tyr Pro Val Gln 
1               5                   10                  15      


Pro Pro Gly Asn Pro Val Tyr Pro Gln Thr Leu His Leu Pro Gln Ala 
            20                  25                  30          


Pro Pro Tyr Thr Asp Ala Pro Pro Ala Tyr Ser Glu Leu Tyr Arg Pro 
        35                  40                  45              


Ser Phe Val His Pro Gly Ala Ala Thr Val Pro Thr Met Ser Ala Ala 
    50                  55                  60                  


Ile Pro Met Ala Tyr Tyr Pro Val Gly Pro Ile Tyr Pro Pro Gly Ser 
65                  70                  75                  80  


Thr Val Leu Val Glu Gly Gly Tyr Asp Ala Gly Ala Arg Phe Gly Ala 
                85                  90                  95      


Gly Ala Thr Ala Gly Asn Ile Pro Pro Pro Pro Pro Gly Cys Pro Pro 
            100                 105                 110         


Asn Ala Ala Gln Leu Ala Val Met Gln Gly Ala Asn Val Leu Val Thr 
        115                 120                 125             


Gln Arg Lys Gly Asn Phe Phe Met Gly Gly Ser Asp Gly Gly Tyr Thr 
    130                 135                 140                 


Ile Trp 
145     


<210>  3964
<211>  86
<212>  PRT
<213>  Homo Sapiens

<400>  3964

Met Asn Ser Lys Gly Gln Tyr Pro Thr Gln Pro Thr Tyr Pro Val Gln 
1               5                   10                  15      


Pro Pro Gly Asn Pro Val Tyr Pro Gln Thr Leu His Leu Pro Gln Ala 
            20                  25                  30          


Pro Pro Tyr Thr Asp Ala Pro Pro Ala Tyr Ser Glu Pro Pro Pro Pro 
        35                  40                  45              


Gly Cys Pro Pro Asn Ala Ala Gln Leu Ala Val Met Gln Gly Ala Asn 
    50                  55                  60                  


Val Leu Val Thr Gln Arg Lys Gly Asn Phe Phe Met Gly Gly Ser Asp 
65                  70                  75                  80  


Gly Gly Tyr Thr Ile Trp 
                85      


<210>  3965
<211>  136
<212>  PRT
<213>  Homo Sapiens

<400>  3965

Met Asn Ser Lys Gly Gln Tyr Pro Thr Gln Pro Thr Tyr Pro Val Gln 
1               5                   10                  15      


Pro Pro Gly Asn Pro Val Tyr Pro Gln Thr Leu His Leu Pro Gln Ala 
            20                  25                  30          


Pro Pro Tyr Thr Asp Ala Pro Pro Ala Tyr Ser Glu Ser Val Ala Val 
        35                  40                  45              


Gly Pro Leu Gly Ser Thr Ile Pro Met Ala Tyr Tyr Pro Val Gly Pro 
    50                  55                  60                  


Ile Tyr Pro Pro Gly Ser Thr Val Leu Val Glu Gly Gly Tyr Asp Ala 
65                  70                  75                  80  


Gly Ala Arg Phe Gly Ala Gly Ala Thr Ala Gly Asn Ile Pro Pro Pro 
                85                  90                  95      


Pro Pro Gly Cys Pro Pro Asn Ala Ala Gln Leu Ala Val Met Gln Gly 
            100                 105                 110         


Ala Asn Val Leu Val Thr Gln Arg Lys Gly Asn Phe Phe Met Gly Gly 
        115                 120                 125             


Ser Asp Gly Gly Tyr Thr Ile Trp 
    130                 135     


<210>  3966
<211>  108
<212>  PRT
<213>  Homo Sapiens

<400>  3966

Met Ser Ala Ala Phe Pro Gly Ala Ser Leu Tyr Leu Pro Met Ala Gln 
1               5                   10                  15      


Ser Val Ala Val Gly Pro Leu Gly Ser Thr Ile Pro Met Ala Tyr Tyr 
            20                  25                  30          


Pro Val Gly Pro Ile Tyr Pro Pro Gly Ser Thr Val Leu Val Glu Gly 
        35                  40                  45              


Gly Tyr Asp Ala Gly Ala Arg Phe Gly Ala Gly Ala Thr Ala Gly Asn 
    50                  55                  60                  


Ile Pro Pro Pro Pro Pro Gly Cys Pro Pro Asn Ala Ala Gln Leu Ala 
65                  70                  75                  80  


Val Met Gln Gly Ala Asn Val Leu Val Thr Gln Arg Lys Gly Asn Phe 
                85                  90                  95      


Phe Met Gly Gly Ser Asp Gly Gly Tyr Thr Ile Trp 
            100                 105             


<210>  3967
<211>  617
<212>  PRT
<213>  Homo Sapiens

<400>  3967

Met Pro Ala Leu Ser Arg Trp Ala Ser Leu Pro Gly Pro Ser Met Arg 
1               5                   10                  15      


Glu Ala Ala Phe Met Tyr Ser Thr Ala Val Ala Ile Phe Leu Val Ile 
            20                  25                  30          


Leu Val Ala Ala Leu Gln Gly Ser Ala Pro Arg Glu Ser Pro Leu Pro 
        35                  40                  45              


Tyr His Ile Pro Leu Asp Pro Glu Gly Ser Leu Glu Leu Ser Trp Asn 
    50                  55                  60                  


Val Ser Tyr Thr Gln Glu Ala Ile His Phe Gln Leu Leu Val Arg Arg 
65                  70                  75                  80  


Leu Lys Ala Gly Val Leu Phe Gly Met Ser Asp Arg Gly Glu Leu Glu 
                85                  90                  95      


Asn Ala Asp Leu Val Val Leu Trp Thr Asp Gly Asp Thr Ala Tyr Phe 
            100                 105                 110         


Ala Asp Ala Trp Ser Asp Gln Lys Gly Gln Ile His Leu Asp Pro Gln 
        115                 120                 125             


Gln Asp Tyr Gln Leu Leu Gln Val Gln Arg Thr Pro Glu Gly Leu Thr 
    130                 135                 140                 


Leu Leu Phe Lys Arg Pro Phe Gly Thr Cys Asp Pro Lys Asp Tyr Leu 
145                 150                 155                 160 


Ile Glu Asp Gly Thr Val His Leu Val Tyr Gly Ile Leu Glu Glu Pro 
                165                 170                 175     


Phe Arg Ser Leu Glu Ala Ile Asn Gly Ser Gly Leu Gln Met Gly Leu 
            180                 185                 190         


Gln Arg Val Gln Leu Leu Lys Pro Asn Ile Pro Glu Pro Glu Leu Pro 
        195                 200                 205             


Ser Asp Ala Cys Thr Met Glu Val Gln Ala Pro Asn Ile Gln Ile Pro 
    210                 215                 220                 


Ser Gln Glu Thr Thr Tyr Trp Cys Tyr Ile Lys Glu Leu Pro Lys Gly 
225                 230                 235                 240 


Phe Ser Arg His His Ile Ile Lys Tyr Glu Pro Ile Val Thr Lys Gly 
                245                 250                 255     


Asn Glu Ala Leu Val His His Met Glu Val Phe Gln Cys Ala Pro Glu 
            260                 265                 270         


Met Asp Ser Val Pro His Phe Ser Gly Pro Cys Asp Ser Lys Met Lys 
        275                 280                 285             


Pro Asp Arg Leu Asn Tyr Cys Arg His Val Leu Ala Ala Trp Ala Leu 
    290                 295                 300                 


Gly Ala Lys Ala Phe Tyr Tyr Pro Glu Glu Ala Gly Leu Ala Phe Gly 
305                 310                 315                 320 


Gly Pro Gly Ser Ser Arg Tyr Leu Arg Leu Glu Val His Tyr His Asn 
                325                 330                 335     


Pro Leu Val Ile Glu Gly Arg Asn Asp Ser Ser Gly Ile Arg Leu Tyr 
            340                 345                 350         


Tyr Thr Ala Lys Leu Arg Arg Phe Asn Ala Gly Ile Met Glu Leu Gly 
        355                 360                 365             


Leu Val Tyr Thr Pro Val Met Ala Ile Pro Pro Arg Glu Thr Ala Phe 
    370                 375                 380                 


Ile Leu Thr Gly Tyr Cys Thr Asp Lys Cys Thr Gln Leu Ala Leu Pro 
385                 390                 395                 400 


Pro Ser Gly Ile His Ile Phe Ala Ser Gln Leu His Thr His Leu Thr 
                405                 410                 415     


Gly Arg Lys Val Val Thr Val Leu Val Arg Asp Gly Arg Glu Trp Glu 
            420                 425                 430         


Ile Val Asn Gln Asp Asn His Tyr Ser Pro His Phe Gln Glu Ile Arg 
        435                 440                 445             


Met Leu Lys Lys Val Val Ser Val His Pro Gly Asp Val Leu Ile Thr 
    450                 455                 460                 


Ser Cys Thr Tyr Asn Thr Glu Asp Arg Glu Leu Ala Thr Val Gly Gly 
465                 470                 475                 480 


Phe Gly Ile Leu Glu Glu Met Cys Val Asn Tyr Val His Tyr Tyr Pro 
                485                 490                 495     


Gln Thr Gln Leu Glu Leu Cys Lys Ser Ala Val Asp Ala Gly Phe Leu 
            500                 505                 510         


Gln Lys Tyr Phe His Leu Ile Asn Arg Phe Asn Asn Glu Asp Val Cys 
        515                 520                 525             


Thr Cys Pro Gln Ala Ser Val Ser Gln Gln Phe Thr Ser Val Pro Trp 
    530                 535                 540                 


Asn Ser Phe Asn Arg Asp Val Leu Lys Ala Leu Tyr Ser Phe Ala Pro 
545                 550                 555                 560 


Ile Ser Met His Cys Asn Lys Ser Ser Ala Val Arg Phe Gln Gly Glu 
                565                 570                 575     


Trp Asn Leu Gln Pro Leu Pro Lys Val Ile Ser Thr Leu Glu Glu Pro 
            580                 585                 590         


Thr Pro Gln Cys Pro Thr Ser Gln Gly Arg Ser Pro Ala Gly Pro Thr 
        595                 600                 605             


Val Val Ser Ile Gly Gly Gly Lys Gly 
    610                 615         


<210>  3968
<211>  244
<212>  PRT
<213>  Homo Sapiens

<400>  3968

Met Arg Glu Ala Ala Phe Met Tyr Ser Thr Ala Val Ala Ile Phe Leu 
1               5                   10                  15      


Val Ile Leu Val Ala Ala Leu Gln Gly Ser Ala Pro Arg Glu Ser Pro 
            20                  25                  30          


Leu Pro Tyr His Ile Pro Leu Asp Pro Glu Gly Ser Leu Glu Leu Ser 
        35                  40                  45              


Trp Asn Val Ser Tyr Thr Gln Glu Ala Ile His Phe Gln Leu Leu Val 
    50                  55                  60                  


Arg Arg Leu Lys Ala Gly Val Leu Phe Gly Met Ser Asp Arg Gly Glu 
65                  70                  75                  80  


Leu Glu Asn Ala Asp Leu Val Val Leu Trp Thr Asp Gly Asp Thr Ala 
                85                  90                  95      


Tyr Phe Ala Asp Gly Thr Val His Leu Val Tyr Gly Ile Leu Glu Glu 
            100                 105                 110         


Pro Phe Arg Ser Leu Glu Ala Ile Asn Gly Ser Gly Leu Gln Met Gly 
        115                 120                 125             


Leu Gln Arg Val Gln Leu Leu Lys Pro Asn Ile Pro Glu Pro Glu Leu 
    130                 135                 140                 


Pro Ser Asp Ala Cys Thr Met Glu Val Gln Ala Pro Asn Ile Gln Ile 
145                 150                 155                 160 


Pro Ser Gln Glu Thr Thr Tyr Trp Cys Tyr Ile Lys Glu Leu Pro Lys 
                165                 170                 175     


Gly Phe Ser Arg His His Ile Ile Lys Tyr Glu Pro Ile Val Thr Lys 
            180                 185                 190         


Gly Asn Glu Ala Leu Val His His Met Glu Val Phe Gln Cys Ala Pro 
        195                 200                 205             


Glu Met Asp Ser Val Pro His Phe Ser Gly Pro Cys Asp Ser Lys Met 
    210                 215                 220                 


Lys Pro Asp Arg Leu Asn Tyr Cys Arg His Val Leu Ala Ala Trp Ala 
225                 230                 235                 240 


Leu Gly Ala Lys 
                


<210>  3969
<211>  27
<212>  PRT
<213>  Homo Sapiens

<400>  3969

Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Thr Glu Lys Ser Pro Thr Asp 
            20                  25          


<210>  3970
<211>  50
<212>  PRT
<213>  Homo Sapiens

<400>  3970

Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Thr Glu Lys Ser Pro Thr Asp Trp Ala Leu Phe Thr 
            20                  25                  30          


Tyr Glu Gly Asn Ser Asn Asp Ile Arg Cys Cys Ser Cys Cys Arg Gly 
        35                  40                  45              


Pro Met 
    50  


<210>  3971
<211>  87
<212>  PRT
<213>  Homo Sapiens

<400>  3971

Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Thr Glu Lys Ser Pro Thr Asp Trp Ala Leu Phe Thr 
            20                  25                  30          


Tyr Glu Gly Asn Ser Asn Asp Ile Arg Val Ala Gly Thr Gly Asp Arg 
        35                  40                  45              


Arg Gly Arg Glu Arg Cys Ala Glu Gly Ser Leu Cys Gln Pro Arg Gln 
    50                  55                  60                  


His His Gly Gln Leu Pro Glu Gly Gly Pro Cys Asp His Gln Arg Thr 
65                  70                  75                  80  


Gly Arg Gly Gly Cys Gly Ala 
                85          


<210>  3972
<211>  406
<212>  PRT
<213>  Homo Sapiens

<400>  3972

Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Thr Glu Lys Ser Pro Thr Asp Trp Ala Leu Phe Thr 
            20                  25                  30          


Tyr Glu Gly Asn Ser Asn Asp Ile Arg Val Ala Gly Thr Gly Glu Gly 
        35                  40                  45              


Gly Leu Glu Glu Met Val Glu Glu Leu Asn Ser Gly Lys Val Met Tyr 
    50                  55                  60                  


Ala Phe Cys Arg Val Lys Asp Pro Asn Ser Gly Leu Pro Lys Phe Val 
65                  70                  75                  80  


Leu Ile Asn Trp Gly Ala His Val Thr Ile Asn Ala Arg Ala Glu Glu 
                85                  90                  95      


Asp Val Glu Pro Glu Cys Ile Met Glu Lys Val Ala Lys Ala Ser Gly 
            100                 105                 110         


Ala Asn Tyr Ser Phe His Lys Glu Ser Gly Arg Phe Gln Asp Val Gly 
        115                 120                 125             


Pro Gln Ala Pro Val Gly Ser Val Tyr Gln Lys Thr Asn Ala Val Ser 
    130                 135                 140                 


Glu Ile Lys Arg Val Gly Lys Asp Ser Phe Trp Ala Lys Ala Glu Lys 
145                 150                 155                 160 


Glu Glu Glu Asn Arg Arg Leu Glu Glu Lys Arg Arg Ala Glu Glu Ala 
                165                 170                 175     


Gln Arg Gln Leu Glu Gln Glu Arg Arg Glu Arg Glu Leu Arg Glu Ala 
            180                 185                 190         


Ala Arg Arg Glu Gln Arg Tyr Gln Glu Gln Gly Gly Glu Ala Ser Pro 
        195                 200                 205             


Gln Ser Arg Thr Trp Glu Gln Gln Gln Glu Val Val Ser Arg Asn Arg 
    210                 215                 220                 


Asn Glu Gln Glu Ser Ala Val His Pro Arg Glu Ile Phe Lys Gln Lys 
225                 230                 235                 240 


Glu Arg Ala Met Ser Thr Thr Ser Ile Ser Ser Pro Gln Pro Gly Lys 
                245                 250                 255     


Leu Arg Ser Pro Phe Leu Gln Lys Gln Leu Thr Gln Pro Glu Thr His 
            260                 265                 270         


Phe Gly Arg Glu Pro Ala Ala Ala Ile Ser Arg Pro Arg Ala Asp Leu 
        275                 280                 285             


Pro Ala Glu Glu Pro Ala Pro Ser Thr Pro Pro Cys Leu Val Gln Ala 
    290                 295                 300                 


Glu Glu Glu Ala Val Tyr Glu Glu Pro Pro Glu Gln Glu Thr Phe Tyr 
305                 310                 315                 320 


Glu Gln Pro Pro Leu Val Gln Gln Gln Gly Ala Gly Ser Glu His Ile 
                325                 330                 335     


Asp His His Ile Gln Gly Gln Gly Leu Ser Gly Gln Gly Leu Cys Ala 
            340                 345                 350         


Arg Ala Leu Tyr Asp Tyr Gln Ala Ala Asp Asp Thr Glu Ile Ser Phe 
        355                 360                 365             


Asp Pro Glu Asn Leu Ile Thr Gly Ile Glu Val Ile Asp Glu Gly Trp 
    370                 375                 380                 


Trp Arg Gly Tyr Gly Pro Asp Gly His Phe Gly Met Phe Pro Ala Asn 
385                 390                 395                 400 


Tyr Val Glu Leu Ile Glu 
                405     


<210>  3973
<211>  430
<212>  PRT
<213>  Homo Sapiens

<400>  3973

Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Thr Glu Lys Ser Pro Thr Asp Trp Ala Leu Phe Thr 
            20                  25                  30          


Tyr Glu Gly Asn Ser Asn Asp Ile Arg Val Ala Gly Thr Gly Glu Gly 
        35                  40                  45              


Gly Leu Glu Glu Met Val Glu Glu Leu Asn Ser Gly Lys Val Met Tyr 
    50                  55                  60                  


Ala Phe Cys Arg Val Lys Asp Pro Asn Ser Gly Leu Pro Lys Phe Val 
65                  70                  75                  80  


Leu Ile Asn Trp Thr Gly Glu Gly Val Asn Asp Val Arg Lys Gly Ala 
                85                  90                  95      


Cys Ala Ser His Val Ser Thr Met Ala Ser Phe Leu Lys Gly Ala His 
            100                 105                 110         


Val Thr Ile Asn Ala Arg Ala Glu Glu Asp Val Glu Pro Glu Cys Ile 
        115                 120                 125             


Met Glu Lys Val Ala Lys Ala Ser Gly Ala Asn Tyr Ser Phe His Lys 
    130                 135                 140                 


Glu Ser Gly Arg Phe Gln Asp Val Gly Pro Gln Ala Pro Val Gly Ser 
145                 150                 155                 160 


Val Tyr Gln Lys Thr Asn Ala Val Ser Glu Ile Lys Arg Val Gly Lys 
                165                 170                 175     


Asp Ser Phe Trp Ala Lys Ala Glu Lys Glu Glu Glu Asn Arg Arg Leu 
            180                 185                 190         


Glu Glu Lys Arg Arg Ala Glu Glu Ala Gln Arg Gln Leu Glu Gln Glu 
        195                 200                 205             


Arg Arg Glu Arg Glu Leu Arg Glu Ala Ala Arg Arg Glu Gln Arg Tyr 
    210                 215                 220                 


Gln Glu Gln Gly Gly Glu Ala Ser Pro Gln Arg Thr Trp Glu Gln Gln 
225                 230                 235                 240 


Gln Glu Val Val Ser Arg Asn Arg Asn Glu Gln Glu Ser Ala Val His 
                245                 250                 255     


Pro Arg Glu Ile Phe Lys Gln Lys Glu Arg Ala Met Ser Thr Thr Ser 
            260                 265                 270         


Ile Ser Ser Pro Gln Pro Gly Lys Leu Arg Ser Pro Phe Leu Gln Lys 
        275                 280                 285             


Gln Leu Thr Gln Pro Glu Thr His Phe Gly Arg Glu Pro Ala Ala Ala 
    290                 295                 300                 


Ile Ser Arg Pro Arg Ala Asp Leu Pro Ala Glu Glu Pro Ala Pro Ser 
305                 310                 315                 320 


Thr Pro Pro Cys Leu Val Gln Ala Glu Glu Glu Ala Val Tyr Glu Glu 
                325                 330                 335     


Pro Pro Glu Gln Glu Thr Phe Tyr Glu Gln Pro Pro Leu Val Gln Gln 
            340                 345                 350         


Gln Gly Ala Gly Ser Glu His Ile Asp His His Ile Gln Gly Gln Gly 
        355                 360                 365             


Leu Ser Gly Gln Gly Leu Cys Ala Arg Ala Leu Tyr Asp Tyr Gln Ala 
    370                 375                 380                 


Ala Asp Asp Thr Glu Ile Ser Phe Asp Pro Glu Asn Leu Ile Thr Gly 
385                 390                 395                 400 


Ile Glu Val Ile Asp Glu Gly Trp Trp Arg Gly Tyr Gly Pro Asp Gly 
                405                 410                 415     


His Phe Gly Met Phe Pro Ala Asn Tyr Val Glu Leu Ile Glu 
            420                 425                 430 


<210>  3974
<211>  431
<212>  PRT
<213>  Homo Sapiens

<400>  3974

Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Thr Glu Lys Ser Pro Thr Asp Trp Ala Leu Phe Thr 
            20                  25                  30          


Tyr Glu Gly Asn Ser Asn Asp Ile Arg Val Ala Gly Thr Gly Glu Gly 
        35                  40                  45              


Gly Leu Glu Glu Met Val Glu Glu Leu Asn Ser Gly Lys Val Met Tyr 
    50                  55                  60                  


Ala Phe Cys Arg Val Lys Asp Pro Asn Ser Gly Leu Pro Lys Phe Val 
65                  70                  75                  80  


Leu Ile Asn Trp Thr Gly Glu Gly Val Asn Asp Val Arg Lys Gly Ala 
                85                  90                  95      


Cys Ala Ser His Val Ser Thr Met Ala Ser Phe Leu Lys Gly Ala His 
            100                 105                 110         


Val Thr Ile Asn Ala Arg Ala Glu Glu Asp Val Glu Pro Glu Cys Ile 
        115                 120                 125             


Met Glu Lys Val Ala Lys Ala Ser Gly Ala Asn Tyr Ser Phe His Lys 
    130                 135                 140                 


Glu Ser Gly Arg Phe Gln Asp Val Gly Pro Gln Ala Pro Val Gly Ser 
145                 150                 155                 160 


Val Tyr Gln Lys Thr Asn Ala Val Ser Glu Ile Lys Arg Val Gly Lys 
                165                 170                 175     


Asp Ser Phe Trp Ala Lys Ala Glu Lys Glu Glu Glu Asn Arg Arg Leu 
            180                 185                 190         


Glu Glu Lys Arg Arg Ala Glu Glu Ala Gln Arg Gln Leu Glu Gln Glu 
        195                 200                 205             


Arg Arg Glu Arg Glu Leu Arg Glu Ala Ala Arg Arg Glu Gln Arg Tyr 
    210                 215                 220                 


Gln Glu Gln Gly Gly Glu Ala Ser Pro Gln Ser Arg Thr Trp Glu Gln 
225                 230                 235                 240 


Gln Gln Glu Val Val Ser Arg Asn Arg Asn Glu Gln Glu Ser Ala Val 
                245                 250                 255     


His Pro Arg Glu Ile Phe Lys Gln Lys Glu Arg Ala Met Ser Thr Thr 
            260                 265                 270         


Ser Ile Ser Ser Pro Gln Pro Gly Lys Leu Arg Ser Pro Phe Leu Gln 
        275                 280                 285             


Lys Gln Leu Thr Gln Pro Glu Thr His Phe Gly Arg Glu Pro Ala Ala 
    290                 295                 300                 


Ala Ile Ser Arg Pro Arg Ala Asp Leu Pro Ala Glu Glu Pro Ala Pro 
305                 310                 315                 320 


Ser Thr Pro Pro Cys Leu Val Gln Ala Glu Glu Glu Ala Val Tyr Glu 
                325                 330                 335     


Glu Pro Pro Glu Gln Glu Thr Phe Tyr Glu Gln Pro Pro Leu Val Gln 
            340                 345                 350         


Gln Gln Gly Ala Gly Ser Glu His Ile Asp His His Ile Gln Gly Gln 
        355                 360                 365             


Gly Leu Ser Gly Gln Gly Leu Cys Ala Arg Ala Leu Tyr Asp Tyr Gln 
    370                 375                 380                 


Ala Ala Asp Asp Thr Glu Ile Ser Phe Asp Pro Glu Asn Leu Ile Thr 
385                 390                 395                 400 


Gly Ile Glu Val Ile Asp Glu Gly Trp Trp Arg Gly Tyr Gly Pro Asp 
                405                 410                 415     


Gly His Phe Gly Met Phe Pro Ala Asn Tyr Val Glu Leu Ile Glu 
            420                 425                 430     


<210>  3975
<211>  439
<212>  PRT
<213>  Homo Sapiens

<400>  3975

Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Thr Glu Lys Ser Pro Thr Asp Trp Ala Leu Phe Thr 
            20                  25                  30          


Tyr Glu Gly Asn Ser Asn Asp Ile Arg Val Ala Gly Thr Gly Glu Gly 
        35                  40                  45              


Gly Leu Glu Glu Met Val Glu Glu Leu Asn Ser Gly Lys Val Met Tyr 
    50                  55                  60                  


Ala Phe Cys Arg Val Lys Asp Pro Asn Ser Gly Leu Pro Lys Phe Val 
65                  70                  75                  80  


Leu Ile Asn Trp Thr Gly Glu Gly Val Asn Asp Val Arg Lys Gly Ala 
                85                  90                  95      


Cys Ala Ser His Val Ser Thr Met Ala Ser Phe Leu Lys Gly Ala His 
            100                 105                 110         


Val Thr Ile Asn Ala Arg Ala Glu Glu Asp Val Glu Pro Glu Cys Ile 
        115                 120                 125             


Met Glu Lys Val Ala Lys Ala Ser Gly Ala Asn Tyr Ser Phe His Lys 
    130                 135                 140                 


Glu Ser Gly Arg Phe Gln Asp Val Gly Pro Gln Ala Pro Val Gly Ser 
145                 150                 155                 160 


Val Tyr Gln Lys Thr Asn Ala Val Ser Glu Ile Lys Arg Val Gly Lys 
                165                 170                 175     


Asp Ser Phe Trp Ala Lys Ala Glu Lys Glu Glu Glu Asn Arg Arg Leu 
            180                 185                 190         


Glu Glu Lys Arg Arg Ala Glu Glu Ala Gln Arg Gln Leu Glu Gln Glu 
        195                 200                 205             


Arg Arg Glu Arg Glu Leu Arg Glu Ala Ala Arg Arg Glu Gln Arg Tyr 
    210                 215                 220                 


Gln Glu Gln Gly Gly Glu Ala Ser Pro Gln Ser Arg Thr Trp Glu Gln 
225                 230                 235                 240 


Gln Gln Glu Val Val Ser Arg Asn Arg Asn Glu Gln Gly Ser Thr Cys 
                245                 250                 255     


Ala Ser Leu Gln Glu Ser Ala Val His Pro Arg Glu Ile Phe Lys Gln 
            260                 265                 270         


Lys Glu Arg Ala Met Ser Thr Thr Ser Ile Ser Ser Pro Gln Pro Gly 
        275                 280                 285             


Lys Leu Arg Ser Pro Phe Leu Gln Lys Gln Leu Thr Gln Pro Glu Thr 
    290                 295                 300                 


His Phe Gly Arg Glu Pro Ala Ala Ala Ile Ser Arg Pro Arg Ala Asp 
305                 310                 315                 320 


Leu Pro Ala Glu Glu Pro Ala Pro Ser Thr Pro Pro Cys Leu Val Gln 
                325                 330                 335     


Ala Glu Glu Glu Ala Val Tyr Glu Glu Pro Pro Glu Gln Glu Thr Phe 
            340                 345                 350         


Tyr Glu Gln Pro Pro Leu Val Gln Gln Gln Gly Ala Gly Ser Glu His 
        355                 360                 365             


Ile Asp His His Ile Gln Gly Gln Gly Leu Ser Gly Gln Gly Leu Cys 
    370                 375                 380                 


Ala Arg Ala Leu Tyr Asp Tyr Gln Ala Ala Asp Asp Thr Glu Ile Ser 
385                 390                 395                 400 


Phe Asp Pro Glu Asn Leu Ile Thr Gly Ile Glu Val Ile Asp Glu Gly 
                405                 410                 415     


Trp Trp Arg Gly Tyr Gly Pro Asp Gly His Phe Gly Met Phe Pro Ala 
            420                 425                 430         


Asn Tyr Val Glu Leu Ile Glu 
        435                 


<210>  3976
<211>  382
<212>  PRT
<213>  Homo Sapiens

<400>  3976

Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Thr Glu Lys Ser Pro Thr Asp Trp Ala Leu Phe Thr 
            20                  25                  30          


Tyr Glu Gly Asn Ser Asn Asp Ile Arg Val Ala Gly Thr Gly Glu Gly 
        35                  40                  45              


Gly Leu Glu Glu Met Val Glu Glu Leu Asn Ser Gly Lys Val Met Tyr 
    50                  55                  60                  


Ala Phe Cys Arg Val Lys Asp Pro Asn Ser Gly Leu Pro Lys Phe Val 
65                  70                  75                  80  


Leu Ile Asn Trp Thr Gly Glu Gly Val Asn Asp Val Arg Lys Gly Ala 
                85                  90                  95      


Cys Ala Ser His Val Ser Thr Met Ala Ser Phe Leu Lys Gly Ser Val 
            100                 105                 110         


Tyr Gln Lys Thr Asn Ala Val Ser Glu Ile Lys Arg Val Gly Lys Asp 
        115                 120                 125             


Ser Phe Trp Ala Lys Ala Glu Lys Glu Glu Glu Asn Arg Arg Leu Glu 
    130                 135                 140                 


Glu Lys Arg Arg Ala Glu Glu Ala Gln Arg Gln Leu Glu Gln Glu Arg 
145                 150                 155                 160 


Arg Glu Arg Glu Leu Arg Glu Ala Ala Arg Arg Glu Gln Arg Tyr Gln 
                165                 170                 175     


Glu Gln Gly Gly Glu Ala Ser Pro Gln Ser Arg Thr Trp Glu Gln Gln 
            180                 185                 190         


Gln Glu Val Val Ser Arg Asn Arg Asn Glu Gln Glu Ser Ala Val His 
        195                 200                 205             


Pro Arg Glu Ile Phe Lys Gln Lys Glu Arg Ala Met Ser Thr Thr Ser 
    210                 215                 220                 


Ile Ser Ser Pro Gln Pro Gly Lys Leu Arg Ser Pro Phe Leu Gln Lys 
225                 230                 235                 240 


Gln Leu Thr Gln Pro Glu Thr His Phe Gly Arg Glu Pro Ala Ala Ala 
                245                 250                 255     


Ile Ser Arg Pro Arg Ala Asp Leu Pro Ala Glu Glu Pro Ala Pro Ser 
            260                 265                 270         


Thr Pro Pro Cys Leu Val Gln Ala Glu Glu Glu Ala Val Tyr Glu Glu 
        275                 280                 285             


Pro Pro Glu Gln Glu Thr Phe Tyr Glu Gln Pro Pro Leu Val Gln Gln 
    290                 295                 300                 


Gln Gly Ala Gly Ser Glu His Ile Asp His His Ile Gln Gly Gln Gly 
305                 310                 315                 320 


Leu Ser Gly Gln Gly Leu Cys Ala Arg Ala Leu Tyr Asp Tyr Gln Ala 
                325                 330                 335     


Ala Asp Asp Thr Glu Ile Ser Phe Asp Pro Glu Asn Leu Ile Thr Gly 
            340                 345                 350         


Ile Glu Val Ile Asp Glu Gly Trp Trp Arg Gly Tyr Gly Pro Asp Gly 
        355                 360                 365             


His Phe Gly Met Phe Pro Ala Asn Tyr Val Glu Leu Ile Glu 
    370                 375                 380         


<210>  3977
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  3977

Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Thr Glu Lys Ser Pro Thr Asp Trp Ala Leu Phe Thr 
            20                  25                  30          


Tyr Glu Gly Asn Ser Asn Asp Ile Arg Val Ala Gly Thr Gly Glu Gly 
        35                  40                  45              


Gly Leu Glu Glu Met Val Glu Glu Leu Asn Ser Gly Lys Val Met Tyr 
    50                  55                  60                  


Ala Phe Cys Arg Val Lys Asp Pro Asn Ser Gly Leu Pro Lys Phe Val 
65                  70                  75                  80  


Leu Ile Asn Trp Thr Gly Glu Gly Val Asn Asp Val Arg Lys Gly Ala 
                85                  90                  95      


Cys Ala Ser His Val Ser Thr Met Ala Ser Phe Leu Lys Val Arg Pro 
            100                 105                 110         


Gly Gly Pro Cys Asp His Gln Arg Thr Gly Arg Gly Gly Cys Gly Ala 
        115                 120                 125             


<210>  3978
<211>  62
<212>  PRT
<213>  Homo Sapiens

<400>  3978

Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Thr Glu Lys Ser Pro Thr Asp Trp Ala Leu Phe Thr 
            20                  25                  30          


Tyr Glu Gly Asn Ser Asn Asp Ile Arg Val Ala Gly Thr Gly Gly Gly 
        35                  40                  45              


Pro Cys Asp His Gln Arg Thr Gly Arg Gly Gly Cys Gly Ala 
    50                  55                  60          


<210>  3979
<211>  31
<212>  PRT
<213>  Homo Sapiens

<400>  3979

Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Thr Glu Lys Ser Pro Thr Asp Trp Gly Pro Met 
            20                  25                  30      


<210>  3980
<211>  40
<212>  PRT
<213>  Homo Sapiens

<400>  3980

Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Thr Glu Lys Ser Pro Thr Asp Trp Trp Ala Ala Arg 
            20                  25                  30          


Arg Ala Arg Gly Ser Leu Tyr Leu 
        35                  40  


<210>  3981
<211>  48
<212>  PRT
<213>  Homo Sapiens

<400>  3981

Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Thr Glu Lys Ser Pro Thr Asp Trp Trp Ala Ala Arg 
            20                  25                  30          


Arg Ala Arg Val Gly Pro Gly Ala Ala Ser Gly Gly Ser Leu Tyr Leu 
        35                  40                  45              


<210>  3982
<211>  48
<212>  PRT
<213>  Homo Sapiens

<400>  3982

Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Thr Glu Lys Ser Pro Thr Asp Trp Trp Ala Ala Arg 
            20                  25                  30          


Arg Ala Arg Val Gly Pro Gly Ala Ala Ser Gly Gly Ser Leu Tyr Leu 
        35                  40                  45              


<210>  3983
<211>  327
<212>  PRT
<213>  Homo Sapiens

<400>  3983

Met Ala Ser Phe Leu Lys Gly Ala His Val Thr Ile Asn Ala Arg Ala 
1               5                   10                  15      


Glu Glu Asp Val Glu Pro Glu Cys Ile Met Glu Lys Val Ala Lys Ala 
            20                  25                  30          


Ser Gly Ala Asn Tyr Ser Phe His Lys Glu Ser Gly Arg Phe Gln Asp 
        35                  40                  45              


Val Gly Pro Gln Ala Pro Val Gly Ser Val Tyr Gln Lys Thr Asn Ala 
    50                  55                  60                  


Val Ser Glu Ile Lys Arg Val Gly Lys Asp Ser Phe Trp Ala Lys Ala 
65                  70                  75                  80  


Glu Lys Glu Glu Glu Asn Arg Arg Leu Glu Glu Lys Arg Arg Ala Glu 
                85                  90                  95      


Glu Ala Gln Arg Gln Leu Glu Gln Glu Arg Arg Glu Arg Glu Leu Arg 
            100                 105                 110         


Glu Ala Ala Arg Arg Glu Gln Arg Tyr Gln Glu Gln Gly Gly Glu Ala 
        115                 120                 125             


Ser Pro Gln Arg Thr Trp Glu Gln Gln Gln Glu Val Val Ser Arg Asn 
    130                 135                 140                 


Arg Asn Glu Gln Glu Ser Ala Val His Pro Arg Glu Ile Phe Lys Gln 
145                 150                 155                 160 


Lys Glu Arg Ala Met Ser Thr Thr Ser Ile Ser Ser Pro Gln Pro Gly 
                165                 170                 175     


Lys Leu Arg Ser Pro Phe Leu Gln Lys Gln Leu Thr Gln Pro Glu Thr 
            180                 185                 190         


His Phe Gly Arg Glu Pro Ala Ala Ala Ile Ser Arg Pro Arg Ala Asp 
        195                 200                 205             


Leu Pro Ala Glu Glu Pro Ala Pro Ser Thr Pro Pro Cys Leu Val Gln 
    210                 215                 220                 


Ala Glu Glu Glu Ala Val Tyr Glu Glu Pro Pro Glu Gln Glu Thr Phe 
225                 230                 235                 240 


Tyr Glu Gln Pro Pro Leu Val Gln Gln Gln Gly Ala Gly Ser Glu His 
                245                 250                 255     


Ile Asp His His Ile Gln Gly Gln Gly Leu Ser Gly Gln Gly Leu Cys 
            260                 265                 270         


Ala Arg Ala Leu Tyr Asp Tyr Gln Ala Ala Asp Asp Thr Glu Ile Ser 
        275                 280                 285             


Phe Asp Pro Glu Asn Leu Ile Thr Gly Ile Glu Val Ile Asp Glu Gly 
    290                 295                 300                 


Trp Trp Arg Gly Tyr Gly Pro Asp Gly His Phe Gly Met Phe Pro Ala 
305                 310                 315                 320 


Asn Tyr Val Glu Leu Ile Glu 
                325         


<210>  3984
<211>  336
<212>  PRT
<213>  Homo Sapiens

<400>  3984

Met Lys Ala Thr Ala Met Thr Ser Ala Trp Leu Ala Gln Gly Gly Ala 
1               5                   10                  15      


His Val Thr Ile Asn Ala Arg Ala Glu Glu Asp Val Glu Pro Glu Cys 
            20                  25                  30          


Ile Met Glu Lys Val Ala Lys Ala Ser Gly Ala Asn Tyr Ser Phe His 
        35                  40                  45              


Lys Glu Ser Gly Arg Phe Gln Asp Val Gly Pro Gln Ala Pro Val Gly 
    50                  55                  60                  


Ser Val Tyr Gln Lys Thr Asn Ala Val Ser Glu Ile Lys Arg Val Gly 
65                  70                  75                  80  


Lys Asp Ser Phe Trp Ala Lys Ala Glu Lys Glu Glu Glu Asn Arg Arg 
                85                  90                  95      


Leu Glu Glu Lys Arg Arg Ala Glu Glu Ala Gln Arg Gln Leu Glu Gln 
            100                 105                 110         


Glu Arg Arg Glu Arg Glu Leu Arg Glu Ala Ala Arg Arg Glu Gln Arg 
        115                 120                 125             


Tyr Gln Glu Gln Gly Gly Glu Ala Ser Pro Gln Ser Arg Thr Trp Glu 
    130                 135                 140                 


Gln Gln Gln Glu Val Val Ser Arg Asn Arg Asn Glu Gln Glu Ser Ala 
145                 150                 155                 160 


Val His Pro Arg Glu Ile Phe Lys Gln Lys Glu Arg Ala Met Ser Thr 
                165                 170                 175     


Thr Ser Ile Ser Ser Pro Gln Pro Gly Lys Leu Arg Ser Pro Phe Leu 
            180                 185                 190         


Gln Lys Gln Leu Thr Gln Pro Glu Thr His Phe Gly Arg Glu Pro Ala 
        195                 200                 205             


Ala Ala Ile Ser Arg Pro Arg Ala Asp Leu Pro Ala Glu Glu Pro Ala 
    210                 215                 220                 


Pro Ser Thr Pro Pro Cys Leu Val Gln Ala Glu Glu Glu Ala Val Tyr 
225                 230                 235                 240 


Glu Glu Pro Pro Glu Gln Glu Thr Phe Tyr Glu Gln Pro Pro Leu Val 
                245                 250                 255     


Gln Gln Gln Gly Ala Gly Ser Glu His Ile Asp His His Ile Gln Gly 
            260                 265                 270         


Gln Gly Leu Ser Gly Gln Gly Leu Cys Ala Arg Ala Leu Tyr Asp Tyr 
        275                 280                 285             


Gln Ala Ala Asp Asp Thr Glu Ile Ser Phe Asp Pro Glu Asn Leu Ile 
    290                 295                 300                 


Thr Gly Ile Glu Val Ile Asp Glu Gly Trp Trp Arg Gly Tyr Gly Pro 
305                 310                 315                 320 


Asp Gly His Phe Gly Met Phe Pro Ala Asn Tyr Val Glu Leu Ile Glu 
                325                 330                 335     


<210>  3985
<211>  359
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3985

Xaa Ala Thr Ala Met Thr Ser Ala Trp Leu Ala Gln Gly Thr Gly Glu 
1               5                   10                  15      


Gly Val Asn Asp Val Arg Lys Gly Ala Cys Ala Ser His Val Ser Thr 
            20                  25                  30          


Met Ala Ser Phe Leu Lys Gly Ala His Val Thr Ile Asn Ala Arg Ala 
        35                  40                  45              


Glu Glu Asp Val Glu Pro Glu Cys Ile Met Glu Lys Val Ala Lys Ala 
    50                  55                  60                  


Ser Gly Ala Asn Tyr Ser Phe His Lys Glu Ser Gly Arg Phe Gln Asp 
65                  70                  75                  80  


Val Gly Pro Gln Ala Pro Val Gly Ser Val Tyr Gln Lys Thr Asn Ala 
                85                  90                  95      


Val Ser Glu Ile Lys Arg Val Gly Lys Asp Ser Phe Trp Ala Lys Ala 
            100                 105                 110         


Glu Lys Glu Glu Glu Asn Arg Arg Leu Glu Glu Lys Arg Arg Ala Glu 
        115                 120                 125             


Glu Ala Gln Arg Gln Leu Glu Gln Glu Arg Arg Glu Arg Glu Leu Arg 
    130                 135                 140                 


Glu Ala Ala Arg Arg Glu Gln Arg Tyr Gln Glu Gln Gly Gly Glu Ala 
145                 150                 155                 160 


Ser Pro Gln Arg Thr Trp Glu Gln Gln Gln Glu Val Val Ser Arg Asn 
                165                 170                 175     


Arg Asn Glu Gln Glu Ser Ala Val His Pro Arg Glu Ile Phe Lys Gln 
            180                 185                 190         


Lys Glu Arg Ala Met Ser Thr Thr Ser Ile Ser Ser Pro Gln Pro Gly 
        195                 200                 205             


Lys Leu Arg Ser Pro Phe Leu Gln Lys Gln Leu Thr Gln Pro Glu Thr 
    210                 215                 220                 


His Phe Gly Arg Glu Pro Ala Ala Ala Ile Ser Arg Pro Arg Ala Asp 
225                 230                 235                 240 


Leu Pro Ala Glu Glu Pro Ala Pro Ser Thr Pro Pro Cys Leu Val Gln 
                245                 250                 255     


Ala Glu Glu Glu Ala Val Tyr Glu Glu Pro Pro Glu Gln Glu Thr Phe 
            260                 265                 270         


Tyr Glu Gln Pro Pro Leu Val Gln Gln Gln Gly Ala Gly Ser Glu His 
        275                 280                 285             


Ile Asp His His Ile Gln Gly Gln Gly Leu Ser Gly Gln Gly Leu Cys 
    290                 295                 300                 


Ala Arg Ala Leu Tyr Asp Tyr Gln Ala Ala Asp Asp Thr Glu Ile Ser 
305                 310                 315                 320 


Phe Asp Pro Glu Asn Leu Ile Thr Gly Ile Glu Val Ile Asp Glu Gly 
                325                 330                 335     


Trp Trp Arg Gly Tyr Gly Pro Asp Gly His Phe Gly Met Phe Pro Ala 
            340                 345                 350         


Asn Tyr Val Glu Leu Ile Glu 
        355                 


<210>  3986
<211>  138
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3986

Xaa Lys Gln Lys Glu Arg Ala Met Ser Thr Thr Ser Ile Ser Ser Pro 
1               5                   10                  15      


Gln Pro Asp Leu Pro Ala Glu Glu Pro Ala Pro Ser Thr Pro Pro Cys 
            20                  25                  30          


Leu Val Gln Ala Glu Glu Glu Ala Val Tyr Glu Glu Pro Pro Glu Gln 
        35                  40                  45              


Glu Thr Phe Tyr Glu Gln Pro Pro Leu Val Gln Gln Gln Gly Ala Gly 
    50                  55                  60                  


Ser Glu His Ile Asp His His Ile Gln Gly Gln Gly Leu Ser Gly Gln 
65                  70                  75                  80  


Gly Leu Cys Ala Arg Ala Leu Tyr Asp Tyr Gln Ala Ala Asp Asp Thr 
                85                  90                  95      


Glu Ile Ser Phe Asp Pro Glu Asn Leu Ile Thr Gly Ile Glu Val Ile 
            100                 105                 110         


Asp Glu Gly Trp Trp Arg Gly Tyr Gly Pro Asp Gly His Phe Gly Met 
        115                 120                 125             


Phe Pro Ala Asn Tyr Val Glu Leu Ile Glu 
    130                 135             


<210>  3987
<211>  77
<212>  PRT
<213>  Homo Sapiens

<400>  3987

Met Arg Phe Met Thr Leu Leu Phe Leu Thr Ala Leu Ala Gly Ala Leu 
1               5                   10                  15      


Val Cys Ala Tyr Asp Pro Glu Ala Ala Ser Ala Pro Gly Ser Gly Asn 
            20                  25                  30          


His Lys Gln Met Asp Cys Leu Gln Leu Gln Lys Pro Pro Ser Glu Thr 
        35                  40                  45              


Ala Lys Phe Leu Ser Ser Ser Thr Asn Leu Pro Arg Arg Glu Lys Leu 
    50                  55                  60                  


Val Pro Ser Ala Lys Pro Pro His Thr Arg Gly Leu Val 
65                  70                  75          


<210>  3988
<211>  110
<212>  PRT
<213>  Homo Sapiens

<400>  3988

Met Arg Phe Met Thr Leu Leu Phe Leu Thr Ala Leu Ala Gly Ala Leu 
1               5                   10                  15      


Val Cys Ala Tyr Asp Pro Glu Ala Ala Ser Ala Pro Gly Ser Gly Asn 
            20                  25                  30          


Pro Cys His Glu Ala Ser Ala Ala Gln Lys Glu Asn Ala Gly Glu Asp 
        35                  40                  45              


Pro Gly Leu Ala Arg Gln Ala Pro Lys Pro Arg Lys Gln Arg Ser Ser 
    50                  55                  60                  


Leu Leu Glu Lys Gly Leu Asp Gly Ala Lys Lys Ala Val Gly Gly Leu 
65                  70                  75                  80  


Gly Lys Leu Gly Lys Asp Ala Val Glu Asp Leu Glu Ser Val Gly Lys 
                85                  90                  95      


Gly Ala Val His Asp Val Lys Asp Val Leu Asp Ser Val Leu 
            100                 105                 110 


<210>  3989
<211>  121
<212>  PRT
<213>  Homo Sapiens

<400>  3989

Met Arg Phe Met Thr Leu Leu Phe Leu Thr Ala Leu Ala Gly Ala Leu 
1               5                   10                  15      


Val Cys Ala Tyr Asp Pro Glu Ala Ala Ser Ala Pro Gly Ser Gly Asn 
            20                  25                  30          


Pro Cys His Glu Ala Ser Ala Ala Gln Lys Glu Asn Ala Gly Glu Asp 
        35                  40                  45              


Pro Gly Leu Ala Arg Gln Ala Pro Lys Pro Arg Lys Gln Arg Ser Ser 
    50                  55                  60                  


Leu Leu Glu Lys Gly Leu Asp Gly Ala Lys Lys Ala Val Gly Gly Leu 
65                  70                  75                  80  


Gly Lys Leu Gly Lys Asp Ala Val Glu Asp Leu Glu Ser Val Gly Lys 
                85                  90                  95      


Gly Gly Glu Glu Arg Leu Val Phe Gly Ala Pro Val Asn Leu Thr Ser 
            100                 105                 110         


Ile Pro Leu Thr Ser Val Ser Arg Pro 
        115                 120     


<210>  3990
<211>  100
<212>  PRT
<213>  Homo Sapiens

<400>  3990

Met Lys Ala Thr Ile Ile Leu Leu Leu Leu Ala Gln Val Ser Trp Ala 
1               5                   10                  15      


Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
            20                  25                  30          


Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro 
        35                  40                  45              


Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val 
    50                  55                  60                  


Val Gln Cys Ser Asp Leu Glu Lys Phe Gly Leu Glu Ile Pro Arg Ala 
65                  70                  75                  80  


Leu His Leu Glu Asp Lys Ser Pro Glu Arg Leu Lys Leu Ser Gly Trp 
                85                  90                  95      


Ala Lys Gly Glu 
            100 


<210>  3991
<211>  98
<212>  PRT
<213>  Homo Sapiens

<400>  3991

Met Lys Ala Thr Ile Ile Leu Leu Leu Leu Ala Gln Val Ser Trp Ala 
1               5                   10                  15      


Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
            20                  25                  30          


Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro 
        35                  40                  45              


Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val 
    50                  55                  60                  


Val Gln Cys Ser Asp Leu Glu Lys Lys Tyr Cys Asn Asn Leu Ser Ser 
65                  70                  75                  80  


Tyr Asn Leu Tyr Thr Thr Asn Cys Leu Ile Leu Cys Arg Leu Phe Thr 
                85                  90                  95      


His His 
        


<210>  3992
<211>  98
<212>  PRT
<213>  Homo Sapiens

<400>  3992

Met Lys Ala Thr Ile Ile Leu Leu Leu Leu Ala Gln Val Ser Trp Ala 
1               5                   10                  15      


Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
            20                  25                  30          


Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro 
        35                  40                  45              


Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val 
    50                  55                  60                  


Val Gln Cys Ser Asp Leu Glu Lys Lys Tyr Cys Asn Asn Leu Ser Ser 
65                  70                  75                  80  


Tyr Asn Leu Tyr Thr Thr Asn Cys Leu Ile Leu Cys Arg Leu Phe Thr 
                85                  90                  95      


His His 
        


<210>  3993
<211>  250
<212>  PRT
<213>  Homo Sapiens

<400>  3993

Met Lys Ala Thr Ile Ile Leu Leu Leu Leu Ala Gln Val Ser Trp Ala 
1               5                   10                  15      


Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
            20                  25                  30          


Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro 
        35                  40                  45              


Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val 
    50                  55                  60                  


Val Gln Cys Ser Asp Leu Glu Leu Gly Thr Asn Pro Leu Lys Ser Ser 
65                  70                  75                  80  


Gly Ile Glu Asn Gly Ala Phe Gln Gly Met Lys Lys Leu Ser Tyr Ile 
                85                  90                  95      


Arg Ile Ala Asp Thr Asn Ile Thr Ser Ile Pro Gln Gly Leu Pro Pro 
            100                 105                 110         


Ser Leu Thr Glu Leu His Leu Asp Gly Asn Lys Ile Ser Arg Val Asp 
        115                 120                 125             


Ala Ala Ser Leu Lys Gly Leu Asn Asn Leu Ala Lys Leu Gly Leu Ser 
    130                 135                 140                 


Phe Asn Ser Ile Ser Ala Val Asp Asn Gly Ser Leu Ala Asn Thr Pro 
145                 150                 155                 160 


His Leu Arg Glu Leu His Leu Asp Asn Asn Lys Leu Thr Arg Val Pro 
                165                 170                 175     


Gly Gly Leu Ala Glu His Lys Tyr Ile Gln Val Val Tyr Leu His Asn 
            180                 185                 190         


Asn Asn Ile Ser Val Val Gly Ser Ser Asp Phe Cys Pro Pro Gly His 
        195                 200                 205             


Asn Thr Lys Lys Ala Ser Tyr Ser Gly Val Ser Leu Phe Ser Asn Pro 
    210                 215                 220                 


Val Gln Tyr Trp Glu Ile Gln Pro Ser Thr Phe Arg Cys Val Tyr Val 
225                 230                 235                 240 


Arg Ser Ala Ile Gln Leu Gly Asn Tyr Lys 
                245                 250 


<210>  3994
<211>  75
<212>  PRT
<213>  Homo Sapiens

<400>  3994

Met Lys Ala Thr Ile Ile Leu Leu Leu Leu Ala Gln Val Ser Trp Ala 
1               5                   10                  15      


Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
            20                  25                  30          


Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro 
        35                  40                  45              


Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val 
    50                  55                  60                  


Val Gln Cys Ser Asp Leu Gly Cys Leu Pro Ser 
65                  70                  75  


<210>  3995
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  3995

Met Lys Ala Thr Ile Ile Leu Leu Leu Leu Ala Gln Val Ser Trp Ala 
1               5                   10                  15      


Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
            20                  25                  30          


Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro 
        35                  40                  45              


Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val 
    50                  55                  60                  


Val Gln Cys Ser Asp Leu Gly Leu Asp Lys Val Pro Lys Asp Leu Pro 
65                  70                  75                  80  


Pro Asp Thr Thr Leu Leu Asp Leu Gln Asn Asn Lys Ile Thr Glu Ile 
                85                  90                  95      


Lys Asp Gly Asp Phe Lys Asn Leu Lys Asn Leu His Ala Leu Ile Leu 
            100                 105                 110         


Val Asn Asn Lys Ile Ser Lys 
        115                 


<210>  3996
<211>  174
<212>  PRT
<213>  Homo Sapiens

<400>  3996

Met Lys Ala Thr Ile Ile Leu Leu Leu Leu Ala Gln Val Ser Trp Ala 
1               5                   10                  15      


Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
            20                  25                  30          


Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro 
        35                  40                  45              


Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val 
    50                  55                  60                  


Val Gln Cys Ser Asp Leu Gly Leu Asp Lys Val Pro Lys Asp Leu Pro 
65                  70                  75                  80  


Pro Asp Thr Thr Leu Leu Asp Leu Gln Asn Asn Lys Ile Thr Glu Ile 
                85                  90                  95      


Lys Asp Gly Asp Phe Lys Asn Leu Lys Asn Leu His Ala Leu Ile Leu 
            100                 105                 110         


Val Asn Asn Lys Ile Ser Lys Val Ser Pro Gly Ala Phe Thr Pro Leu 
        115                 120                 125             


Val Lys Leu Glu Arg Leu Tyr Leu Ser Lys Asn Gln Leu Lys Glu Leu 
    130                 135                 140                 


Pro Glu Lys Met Pro Lys Thr Leu Gln Glu Leu Arg Ala His Glu Asn 
145                 150                 155                 160 


Glu Ile Thr Lys Val Arg Lys Val Thr Phe Asn Gly Leu Asn 
                165                 170                 


<210>  3997
<211>  178
<212>  PRT
<213>  Homo Sapiens

<400>  3997

Met Lys Ala Thr Ile Ile Leu Leu Leu Leu Ala Gln Val Ser Trp Ala 
1               5                   10                  15      


Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
            20                  25                  30          


Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro 
        35                  40                  45              


Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val 
    50                  55                  60                  


Val Gln Cys Ser Asp Leu Gly Leu Asp Lys Val Pro Lys Asp Leu Pro 
65                  70                  75                  80  


Pro Asp Thr Thr Leu Leu Asp Leu Gln Asn Asn Lys Ile Thr Glu Ile 
                85                  90                  95      


Lys Asp Gly Asp Phe Lys Asn Leu Lys Asn Leu His Ala Leu Ile Leu 
            100                 105                 110         


Val Asn Asn Lys Ile Ser Lys Val Ser Pro Gly Ala Phe Thr Pro Leu 
        115                 120                 125             


Val Lys Leu Glu Arg Leu Tyr Leu Ser Lys Asn Gln Leu Lys Glu Leu 
    130                 135                 140                 


Pro Glu Lys Met Pro Lys Thr Leu Gln Glu Leu Arg Ala His Glu Asn 
145                 150                 155                 160 


Glu Ile Thr Lys Val Arg Lys Val Thr Phe Asn Gly Leu Asn Gln Met 
                165                 170                 175     


Ile Val 
        


<210>  3998
<211>  179
<212>  PRT
<213>  Homo Sapiens

<400>  3998

Met Lys Ala Thr Ile Ile Leu Leu Leu Leu Ala Gln Val Ser Trp Ala 
1               5                   10                  15      


Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
            20                  25                  30          


Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro 
        35                  40                  45              


Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val 
    50                  55                  60                  


Val Gln Cys Ser Asp Leu Gly Leu Asp Lys Val Pro Lys Asp Leu Pro 
65                  70                  75                  80  


Pro Asp Thr Thr Leu Leu Asp Leu Gln Asn Asn Lys Ile Thr Glu Ile 
                85                  90                  95      


Lys Asp Gly Asp Phe Lys Asn Leu Lys Asn Leu His Ala Leu Ile Leu 
            100                 105                 110         


Val Asn Asn Lys Ile Ser Lys Val Ser Pro Gly Ala Phe Thr Pro Leu 
        115                 120                 125             


Val Lys Leu Glu Arg Leu Tyr Leu Ser Lys Asn Gln Leu Lys Glu Leu 
    130                 135                 140                 


Pro Glu Lys Met Pro Lys Thr Leu Gln Glu Leu Arg Ala His Glu Asn 
145                 150                 155                 160 


Glu Ile Thr Lys Val Arg Lys Val Thr Phe Asn Gly Leu Asn Gln Met 
                165                 170                 175     


Ile Val Ile 
            


<210>  3999
<211>  359
<212>  PRT
<213>  Homo Sapiens

<400>  3999

Met Lys Ala Thr Ile Ile Leu Leu Leu Leu Ala Gln Val Ser Trp Ala 
1               5                   10                  15      


Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
            20                  25                  30          


Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro 
        35                  40                  45              


Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val 
    50                  55                  60                  


Val Gln Cys Ser Asp Leu Gly Leu Asp Lys Val Pro Lys Asp Leu Pro 
65                  70                  75                  80  


Pro Asp Thr Thr Leu Leu Asp Leu Gln Asn Asn Lys Ile Thr Glu Ile 
                85                  90                  95      


Lys Asp Gly Asp Phe Lys Asn Leu Lys Asn Leu His Ala Leu Ile Leu 
            100                 105                 110         


Val Asn Asn Lys Ile Ser Lys Val Ser Pro Gly Ala Phe Thr Pro Leu 
        115                 120                 125             


Val Lys Leu Glu Arg Leu Tyr Leu Ser Lys Asn Gln Leu Lys Glu Leu 
    130                 135                 140                 


Pro Glu Lys Met Pro Lys Thr Leu Gln Glu Leu Arg Ala His Glu Asn 
145                 150                 155                 160 


Glu Ile Thr Lys Val Arg Lys Val Thr Phe Asn Gly Leu Asn Gln Met 
                165                 170                 175     


Ile Val Ile Glu Leu Gly Thr Asn Pro Leu Lys Ser Ser Gly Ile Glu 
            180                 185                 190         


Asn Gly Ala Phe Gln Gly Met Lys Lys Leu Ser Tyr Ile Arg Ile Ala 
        195                 200                 205             


Asp Thr Asn Ile Thr Ser Ile Pro Gln Gly Leu Pro Pro Ser Leu Thr 
    210                 215                 220                 


Glu Leu His Leu Asp Gly Asn Lys Ile Ser Arg Val Asp Ala Ala Ser 
225                 230                 235                 240 


Leu Lys Gly Leu Asn Asn Leu Ala Lys Leu Gly Leu Ser Phe Asn Ser 
                245                 250                 255     


Ile Ser Ala Val Asp Asn Gly Ser Leu Ala Asn Thr Pro His Leu Arg 
            260                 265                 270         


Glu Leu His Leu Asp Asn Asn Lys Leu Thr Arg Val Pro Gly Gly Leu 
        275                 280                 285             


Ala Glu His Lys Tyr Ile Gln Val Val Tyr Leu His Asn Asn Asn Ile 
    290                 295                 300                 


Ser Val Val Gly Ser Ser Asp Phe Cys Pro Pro Gly His Asn Thr Lys 
305                 310                 315                 320 


Lys Ala Ser Tyr Ser Gly Val Ser Leu Phe Ser Asn Pro Val Gln Tyr 
                325                 330                 335     


Trp Glu Ile Gln Pro Ser Thr Phe Arg Cys Val Tyr Val Arg Ser Ala 
            340                 345                 350         


Ile Gln Leu Gly Asn Tyr Lys 
        355                 


<210>  4000
<211>  359
<212>  PRT
<213>  Homo Sapiens

<400>  4000

Met Lys Ala Thr Ile Ile Leu Leu Leu Leu Ala Gln Val Ser Trp Ala 
1               5                   10                  15      


Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
            20                  25                  30          


Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro 
        35                  40                  45              


Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val 
    50                  55                  60                  


Val Gln Cys Ser Asp Leu Gly Leu Asp Lys Val Pro Lys Asp Leu Pro 
65                  70                  75                  80  


Pro Asp Thr Thr Leu Leu Asp Leu Gln Asn Asn Lys Ile Thr Glu Ile 
                85                  90                  95      


Lys Asp Gly Asp Phe Lys Asn Leu Lys Asn Leu His Ala Leu Ile Leu 
            100                 105                 110         


Val Asn Asn Lys Ile Ser Lys Val Ser Pro Gly Ala Phe Thr Pro Leu 
        115                 120                 125             


Val Lys Leu Glu Arg Leu Tyr Leu Ser Lys Asn Gln Leu Lys Glu Leu 
    130                 135                 140                 


Pro Glu Lys Met Pro Lys Thr Leu Gln Glu Leu Arg Ala His Glu Asn 
145                 150                 155                 160 


Glu Ile Thr Lys Val Arg Lys Val Thr Phe Asn Gly Leu Asn Gln Met 
                165                 170                 175     


Ile Val Ile Glu Leu Gly Thr Asn Pro Leu Lys Ser Ser Gly Ile Glu 
            180                 185                 190         


Asn Gly Ala Phe Gln Gly Met Lys Lys Leu Ser Tyr Ile Arg Ile Ala 
        195                 200                 205             


Asp Thr Asn Ile Thr Ser Ile Pro Gln Gly Leu Pro Pro Ser Leu Thr 
    210                 215                 220                 


Glu Leu His Leu Asp Gly Asn Lys Ile Ser Arg Val Asp Ala Ala Ser 
225                 230                 235                 240 


Leu Lys Gly Leu Asn Asn Leu Ala Lys Leu Gly Leu Ser Phe Asn Ser 
                245                 250                 255     


Ile Ser Ala Val Asp Asn Gly Ser Leu Ala Asn Thr Pro His Leu Arg 
            260                 265                 270         


Glu Leu His Leu Asp Asn Asn Lys Leu Thr Arg Val Pro Gly Gly Leu 
        275                 280                 285             


Ala Glu His Lys Tyr Ile Gln Val Val Tyr Leu His Asn Asn Asn Ile 
    290                 295                 300                 


Ser Val Val Gly Ser Ser Asp Phe Cys Pro Pro Gly His Asn Thr Lys 
305                 310                 315                 320 


Lys Ala Ser Tyr Ser Gly Val Ser Leu Phe Ser Asn Pro Val Gln Tyr 
                325                 330                 335     


Trp Glu Ile Gln Pro Ser Thr Phe Arg Cys Val Tyr Val Arg Ser Ala 
            340                 345                 350         


Ile Gln Leu Gly Asn Tyr Lys 
        355                 


<210>  4001
<211>  359
<212>  PRT
<213>  Homo Sapiens

<400>  4001

Met Lys Ala Thr Ile Ile Leu Leu Leu Leu Ala Gln Val Ser Trp Ala 
1               5                   10                  15      


Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
            20                  25                  30          


Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro 
        35                  40                  45              


Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val 
    50                  55                  60                  


Val Gln Cys Ser Asp Leu Gly Leu Asp Lys Val Pro Lys Asp Leu Pro 
65                  70                  75                  80  


Pro Asp Thr Thr Leu Leu Asp Leu Gln Asn Asn Lys Ile Thr Glu Ile 
                85                  90                  95      


Lys Asp Gly Asp Phe Lys Asn Leu Lys Asn Leu His Ala Leu Ile Leu 
            100                 105                 110         


Val Asn Asn Lys Ile Ser Lys Val Ser Pro Gly Ala Phe Thr Pro Leu 
        115                 120                 125             


Val Lys Leu Glu Arg Leu Tyr Leu Ser Lys Asn Gln Leu Lys Glu Leu 
    130                 135                 140                 


Pro Glu Lys Met Pro Lys Thr Leu Gln Glu Leu Arg Ala His Glu Asn 
145                 150                 155                 160 


Glu Ile Thr Lys Val Arg Lys Val Thr Phe Asn Gly Leu Asn Gln Met 
                165                 170                 175     


Ile Val Ile Glu Leu Gly Thr Asn Pro Leu Lys Ser Ser Gly Ile Glu 
            180                 185                 190         


Asn Gly Ala Phe Gln Gly Met Lys Lys Leu Ser Tyr Ile Arg Ile Ala 
        195                 200                 205             


Asp Thr Asn Ile Thr Ser Ile Pro Gln Gly Leu Pro Pro Ser Leu Thr 
    210                 215                 220                 


Glu Leu His Leu Asp Gly Asn Lys Ile Ser Arg Val Asp Ala Ala Ser 
225                 230                 235                 240 


Leu Lys Gly Leu Asn Asn Leu Ala Lys Leu Gly Leu Ser Phe Asn Ser 
                245                 250                 255     


Ile Ser Ala Val Asp Asn Gly Ser Leu Ala Asn Thr Pro His Leu Arg 
            260                 265                 270         


Glu Leu His Leu Asp Asn Asn Lys Leu Thr Arg Val Pro Gly Gly Leu 
        275                 280                 285             


Ala Glu His Lys Tyr Ile Gln Val Val Tyr Leu His Asn Asn Asn Ile 
    290                 295                 300                 


Ser Val Val Gly Ser Ser Asp Phe Cys Pro Pro Gly His Asn Thr Lys 
305                 310                 315                 320 


Lys Ala Ser Tyr Ser Gly Val Ser Leu Phe Ser Asn Pro Val Gln Tyr 
                325                 330                 335     


Trp Glu Ile Gln Pro Ser Thr Phe Arg Cys Val Tyr Val Arg Ser Ala 
            340                 345                 350         


Ile Gln Leu Gly Asn Tyr Lys 
        355                 


<210>  4002
<211>  172
<212>  PRT
<213>  Homo Sapiens

<400>  4002

Met Lys Ala Thr Ile Ile Leu Leu Leu Leu Ala Gln Val Ser Trp Ala 
1               5                   10                  15      


Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
            20                  25                  30          


Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro 
        35                  40                  45              


Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val 
    50                  55                  60                  


Val Gln Cys Ser Asp Leu Gly Leu Asp Lys Val Pro Lys Asp Leu Pro 
65                  70                  75                  80  


Pro Asp Thr Thr Leu Leu Asp Leu Gln Asn Asn Lys Ile Thr Glu Ile 
                85                  90                  95      


Lys Asp Gly Asp Phe Lys Asn Leu Lys Asn Leu His Val Val Tyr Leu 
            100                 105                 110         


His Asn Asn Asn Ile Ser Val Val Gly Ser Ser Asp Phe Cys Pro Pro 
        115                 120                 125             


Gly His Asn Thr Lys Lys Ala Ser Tyr Ser Gly Val Ser Leu Phe Ser 
    130                 135                 140                 


Asn Pro Val Gln Tyr Trp Glu Ile Gln Pro Ser Thr Phe Arg Cys Val 
145                 150                 155                 160 


Tyr Val Arg Ser Ala Ile Gln Leu Gly Asn Tyr Lys 
                165                 170         


<210>  4003
<211>  177
<212>  PRT
<213>  Homo Sapiens

<400>  4003

Met Lys Ala Thr Ile Ile Leu Leu Leu Leu Ala Gln Val Ser Trp Ala 
1               5                   10                  15      


Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
            20                  25                  30          


Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro 
        35                  40                  45              


Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val 
    50                  55                  60                  


Val Gln Cys Ser Asp Leu Gly Leu Pro Pro Ser Leu Thr Glu Leu His 
65                  70                  75                  80  


Leu Asp Gly Asn Lys Ile Ser Arg Val Asp Ala Ala Ser Leu Lys Gly 
                85                  90                  95      


Leu Asn Asn Leu Ala Lys Leu Gly Leu Ser Phe Asn Ser Ile Ser Ala 
            100                 105                 110         


Val Asp Asn Gly Ser Leu Ala Asn Thr Pro His Leu Arg Glu Leu His 
        115                 120                 125             


Leu Asp Asn Asn Lys Leu Thr Arg Val Pro Gly Gly Leu Ala Glu His 
    130                 135                 140                 


Lys Tyr Ile Gln Val Val Tyr Leu His Asn Asn Asn Ile Ser Val Val 
145                 150                 155                 160 


Gly Ser Ser Asp Phe Cys Pro Pro Gly His Asn Thr Lys Lys Ala Ser 
                165                 170                 175     


Tyr 
    


<210>  4004
<211>  212
<212>  PRT
<213>  Homo Sapiens

<400>  4004

Met Lys Ala Thr Ile Ile Leu Leu Leu Leu Ala Gln Val Ser Trp Ala 
1               5                   10                  15      


Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
            20                  25                  30          


Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro 
        35                  40                  45              


Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val 
    50                  55                  60                  


Val Gln Cys Ser Asp Leu Gly Leu Pro Pro Ser Leu Thr Glu Leu His 
65                  70                  75                  80  


Leu Asp Gly Asn Lys Ile Ser Arg Val Asp Ala Ala Ser Leu Lys Gly 
                85                  90                  95      


Leu Asn Asn Leu Ala Lys Leu Gly Leu Ser Phe Asn Ser Ile Ser Ala 
            100                 105                 110         


Val Asp Asn Gly Ser Leu Ala Asn Thr Pro His Leu Arg Glu Leu His 
        115                 120                 125             


Leu Asp Asn Asn Lys Leu Thr Arg Val Pro Gly Gly Leu Ala Glu His 
    130                 135                 140                 


Lys Tyr Ile Gln Val Val Tyr Leu His Asn Asn Asn Ile Ser Val Val 
145                 150                 155                 160 


Gly Ser Ser Asp Phe Cys Pro Pro Gly His Asn Thr Lys Lys Ala Ser 
                165                 170                 175     


Tyr Ser Gly Val Ser Leu Phe Ser Asn Pro Val Gln Tyr Trp Glu Ile 
            180                 185                 190         


Gln Pro Ser Thr Phe Arg Cys Val Tyr Val Arg Ser Ala Ile Gln Leu 
        195                 200                 205             


Gly Asn Tyr Lys 
    210         


<210>  4005
<211>  212
<212>  PRT
<213>  Homo Sapiens

<400>  4005

Met Lys Ala Thr Ile Ile Leu Leu Leu Leu Ala Gln Val Ser Trp Ala 
1               5                   10                  15      


Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
            20                  25                  30          


Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro 
        35                  40                  45              


Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val 
    50                  55                  60                  


Val Gln Cys Ser Asp Leu Gly Leu Pro Pro Ser Leu Thr Glu Leu His 
65                  70                  75                  80  


Leu Asp Gly Asn Lys Ile Ser Arg Val Asp Ala Ala Ser Leu Lys Gly 
                85                  90                  95      


Leu Asn Asn Leu Ala Lys Leu Gly Leu Ser Phe Asn Ser Ile Ser Ala 
            100                 105                 110         


Val Asp Asn Gly Ser Leu Ala Asn Thr Pro His Leu Arg Glu Leu His 
        115                 120                 125             


Leu Asp Asn Asn Lys Leu Thr Arg Val Pro Gly Gly Leu Ala Glu His 
    130                 135                 140                 


Lys Tyr Ile Gln Val Val Tyr Leu His Asn Asn Asn Ile Ser Val Val 
145                 150                 155                 160 


Gly Ser Ser Asp Phe Cys Pro Pro Gly His Asn Thr Lys Lys Ala Ser 
                165                 170                 175     


Tyr Ser Gly Val Ser Leu Phe Ser Asn Pro Val Gln Tyr Trp Glu Ile 
            180                 185                 190         


Gln Pro Ser Thr Phe Arg Cys Val Tyr Val Arg Ser Ala Ile Gln Leu 
        195                 200                 205             


Gly Asn Tyr Lys 
    210         


<210>  4006
<211>  88
<212>  PRT
<213>  Homo Sapiens

<400>  4006

Met Lys Ala Thr Ile Ile Leu Leu Leu Leu Ala Gln Val Ser Trp Ala 
1               5                   10                  15      


Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
            20                  25                  30          


Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro 
        35                  40                  45              


Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val 
    50                  55                  60                  


Val Gln Cys Ser Asp Leu Val Glu Thr Gly Phe His Arg Val Ser Gln 
65                  70                  75                  80  


Asp Gly Leu Asp Leu Leu Ile Ser 
                85              


<210>  4007
<211>  52
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4007

Xaa Asp Phe Cys Pro Pro Gly His Asn Thr Lys Lys Ala Ser Tyr Ser 
1               5                   10                  15      


Gly Val Ser Leu Phe Ser Asn Pro Val Gln Tyr Trp Glu Ile Gln Pro 
            20                  25                  30          


Ser Thr Phe Arg Cys Val Tyr Val Arg Ser Ala Ile Gln Leu Gly Asn 
        35                  40                  45              


Tyr Lys Lys Lys 
    50          


<210>  4008
<211>  95
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4008

Xaa Lys Ile Ser Arg Val Asp Ala Ala Ser Leu Lys Gly Leu Asn Asn 
1               5                   10                  15      


Leu Ala Lys Leu Gly Leu Ser Phe Asn Ser Ile Ser Ala Val Asp Asn 
            20                  25                  30          


Gly Ser Leu Ala Asn Thr Pro His Leu Arg Glu Leu His Leu Asp Asn 
        35                  40                  45              


Asn Lys Leu Thr Arg Val Pro Gly Gly Leu Ala Glu His Lys Tyr Ile 
    50                  55                  60                  


Gln Val Met Gln Ser His Cys Leu Cys Glu Glu Tyr Pro Lys Ser Lys 
65                  70                  75                  80  


Thr Pro Thr Leu Leu Met Gly Cys Trp Glu Ala Gly Ser Ser Ser 
                85                  90                  95  


<210>  4009
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  4009

Met Asn Arg Arg Arg Lys Phe Leu Leu Ala Ser Val Leu Ala Leu Gln 
1               5                   10                  15      


Asn Ser Ser Phe Ile Tyr Pro Ser Cys Gln Lys Cys Phe Ser Arg Ile 
            20                  25                  30          


Ile Leu Val Ser Lys Arg Ile Leu Lys Thr Asn Leu Asp Lys Val Gln 
        35                  40                  45              


Met Pro Val Thr Ser Tyr Ser Asn Ala Leu Thr Thr Lys Glu Lys Pro 
    50                  55                  60                  


Lys His 
65      


<210>  4010
<211>  75
<212>  PRT
<213>  Homo Sapiens

<400>  4010

Met Asn Arg Arg Arg Lys Phe Leu Leu Ala Ser Val Leu Ala Leu Gln 
1               5                   10                  15      


Asn Ser Ser Phe Ile Tyr Pro Ser Cys Gln Lys Cys Phe Ser Arg Ile 
            20                  25                  30          


Ile Leu Val Ser Lys Arg Ser Asn Cys Pro Lys Cys Gly Ser Thr Gly 
        35                  40                  45              


Glu Ser Gly Asn Ala Asn Tyr Arg Tyr Lys Leu Ser Leu Lys Val Ala 
    50                  55                  60                  


Glu Ser Asn Lys Leu Phe Val Ile Thr Val Phe 
65                  70                  75  


<210>  4011
<211>  76
<212>  PRT
<213>  Homo Sapiens

<400>  4011

Met Asn Arg Arg Arg Lys Phe Leu Leu Ala Ser Val Leu Ala Leu Gln 
1               5                   10                  15      


Asn Ser Ser Phe Ile Tyr Pro Ser Cys Gln Lys Cys Phe Ser Arg Ile 
            20                  25                  30          


Ile Leu Val Ser Lys Arg Ser Asn Cys Pro Lys Cys Gly Ser Thr Gly 
        35                  40                  45              


Glu Ser Gly Asn Ala Asn Tyr Arg Tyr Lys Leu Ser Leu Lys Val Ala 
    50                  55                  60                  


Glu Ser Asn Lys Leu Phe Val Ile Thr Val Phe Gly 
65                  70                  75      


<210>  4012
<211>  120
<212>  PRT
<213>  Homo Sapiens

<400>  4012

Met Asn Arg Arg Arg Lys Phe Leu Leu Ala Ser Val Leu Ala Leu Gln 
1               5                   10                  15      


Asn Ser Ser Phe Ile Tyr Pro Ser Cys Gln Lys Cys Phe Ser Arg Ile 
            20                  25                  30          


Ile Leu Val Ser Lys Arg Ser Asn Cys Pro Lys Cys Gly Ser Thr Gly 
        35                  40                  45              


Glu Ser Gly Asn Ala Asn Tyr Arg Tyr Lys Leu Ser Leu Lys Val Ala 
    50                  55                  60                  


Glu Ser Asn Lys Leu Phe Val Ile Thr Val Phe Gly Ser Cys Leu Asp 
65                  70                  75                  80  


Thr Phe Phe Gly Leu Thr Ala Thr Gly Leu His Arg Ile Leu Lys Thr 
                85                  90                  95      


Asn Leu Asp Lys Val Gln Met Pro Val Thr Ser Tyr Ser Asn Ala Leu 
            100                 105                 110         


Thr Thr Lys Glu Lys Pro Lys His 
        115                 120 


<210>  4013
<211>  120
<212>  PRT
<213>  Homo Sapiens

<400>  4013

Met Asn Arg Arg Arg Lys Phe Leu Leu Ala Ser Val Leu Ala Leu Gln 
1               5                   10                  15      


Asn Ser Ser Phe Ile Tyr Pro Ser Cys Gln Lys Cys Phe Ser Arg Ile 
            20                  25                  30          


Ile Leu Val Ser Lys Arg Ser Asn Cys Pro Lys Cys Gly Ser Thr Gly 
        35                  40                  45              


Glu Ser Gly Asn Ala Asn Tyr Arg Tyr Lys Leu Ser Leu Lys Val Ala 
    50                  55                  60                  


Glu Ser Asn Lys Leu Phe Val Ile Thr Val Phe Gly Ser Cys Leu Asp 
65                  70                  75                  80  


Thr Phe Phe Gly Leu Thr Ala Thr Gly Leu His Arg Ile Leu Lys Thr 
                85                  90                  95      


Asn Leu Asp Lys Val Gln Met Pro Val Thr Ser Tyr Ser Asn Ala Leu 
            100                 105                 110         


Thr Thr Lys Glu Lys Pro Lys His 
        115                 120 


<210>  4014
<211>  123
<212>  PRT
<213>  Homo Sapiens

<400>  4014

Met Asn Arg Arg Arg Lys Phe Leu Leu Ala Ser Val Leu Ala Leu Gln 
1               5                   10                  15      


Asn Ser Ser Phe Ile Tyr Pro Ser Cys Gln Lys Cys Phe Ser Arg Ile 
            20                  25                  30          


Ile Leu Val Ser Lys Arg Ser Asn Cys Pro Lys Cys Gly Ser Thr Gly 
        35                  40                  45              


Glu Ser Gly Asn Ala Asn Tyr Arg Tyr Lys Leu Ser Leu Lys Val Ala 
    50                  55                  60                  


Glu Ser Asn Lys Leu Phe Val Ile Thr Val Phe Gly Ser Cys Leu Asp 
65                  70                  75                  80  


Thr Phe Phe Gly Leu Thr Ala Thr Gly Leu His Arg Tyr Ile Gln Asp 
                85                  90                  95      


Pro Asn Lys Ile Pro Glu Thr Leu Asp Asn Asp Thr Thr Gln Asn Leu 
            100                 105                 110         


Leu Thr Lys Ala Val Glu Thr Cys Phe Val Gly 
        115                 120             


<210>  4015
<211>  178
<212>  PRT
<213>  Homo Sapiens

<400>  4015

Met Asn Arg Arg Arg Lys Phe Leu Leu Ala Ser Val Leu Ala Leu Gln 
1               5                   10                  15      


Asn Ser Ser Phe Ile Tyr Pro Ser Cys Gln Lys Cys Phe Ser Arg Ile 
            20                  25                  30          


Ile Leu Val Ser Lys Arg Ser Asn Cys Pro Lys Cys Gly Ser Thr Gly 
        35                  40                  45              


Glu Ser Gly Asn Ala Asn Tyr Arg Tyr Lys Leu Ser Leu Lys Val Ala 
    50                  55                  60                  


Glu Ser Asn Lys Leu Phe Val Ile Thr Val Phe Gly Ser Cys Leu Asp 
65                  70                  75                  80  


Thr Phe Phe Gly Leu Thr Ala Thr Gly Leu His Arg Tyr Ile Gln Asp 
                85                  90                  95      


Pro Asn Lys Ile Pro Glu Thr Leu Asp Asn Asp Thr Thr Gln Asn Leu 
            100                 105                 110         


Leu Thr Lys Ala Val Glu Thr Cys Phe Val Gly Gln Ser Phe Ile Phe 
        115                 120                 125             


Gly Val Thr Asn Phe Glu Asn Gln Pro Gly Gln Gly Ser Asp Ala Ser 
    130                 135                 140                 


Asn Phe Leu Gln Gln Cys Ser Asp His Lys Arg Lys Ala Lys Ala Leu 
145                 150                 155                 160 


Val Ala Cys Gln Ile Val Leu Pro Asp Pro Ala Thr Gln Asp Ala Lys 
                165                 170                 175     


Thr Lys 
        


<210>  4016
<211>  998
<212>  PRT
<213>  Homo Sapiens

<400>  4016

Met Asn Arg Arg Arg Lys Phe Leu Leu Ala Ser Val Leu Ala Leu Gln 
1               5                   10                  15      


Asn Ser Ser Phe Ile Tyr Pro Ser Cys Gln Lys Cys Phe Ser Arg Ile 
            20                  25                  30          


Ile Leu Val Ser Lys Arg Ser Asn Cys Pro Lys Cys Gly Ser Thr Gly 
        35                  40                  45              


Glu Ser Gly Asn Ala Asn Tyr Arg Tyr Lys Leu Ser Leu Lys Val Ala 
    50                  55                  60                  


Glu Ser Asn Lys Leu Phe Val Ile Thr Val Phe Gly Ser Cys Leu Asp 
65                  70                  75                  80  


Thr Phe Phe Gly Leu Thr Ala Thr Gly Leu His Arg Tyr Ile Gln Asp 
                85                  90                  95      


Pro Asn Lys Ile Pro Glu Thr Leu Asp Asn Asp Thr Thr Gln Asn Leu 
            100                 105                 110         


Leu Thr Lys Ala Val Glu Thr Cys Phe Val Gly Gln Ser Phe Ile Phe 
        115                 120                 125             


Gly Val Thr Asn Phe Glu Asn Gln Pro Gly Gln Gly Ser Asp Ala Ser 
    130                 135                 140                 


Asn Phe Leu Gln Gln Cys Ser Asp His Lys Arg Lys Ala Lys Ala Leu 
145                 150                 155                 160 


Val Ala Cys Gln Ile Val Leu Pro Asp Pro Gly Ile Ala Gly Phe Thr 
                165                 170                 175     


Val Ile Asp Tyr Phe His Gln Leu Leu Gln Thr Phe Asn Phe Arg Lys 
            180                 185                 190         


Leu Gln Cys Asp Ser Gln Ala Pro Asn Asn His Leu Leu Ala Leu Asp 
        195                 200                 205             


His Ser Asn Ser Asp Leu Ser Ser Ile Tyr Thr Ser Asp Ser Thr Ser 
    210                 215                 220                 


Asp Phe Phe Lys Ser Cys Ser Lys Asp Thr Phe Ser Lys Phe Trp Gln 
225                 230                 235                 240 


Pro Ser Leu Glu Phe Thr Cys Ile Val Ser Gln Leu Thr Asp Asn Asp 
                245                 250                 255     


Asp Phe Ser Ala Ser Glu Gln Ser Lys Ala Phe Gly Thr Leu Gln Gln 
            260                 265                 270         


Asn Arg Lys Ser Ile Ser Ile Ala Glu Ala Thr Gly Ser Ser Ser Cys 
        275                 280                 285             


His Asp Pro Ile Gln Asp Ser Trp Ser Leu Val Ser Tyr Met Asp Lys 
    290                 295                 300                 


Lys Ser Thr Ala Glu Lys Leu Gly Lys Glu Leu Gly Leu Gln Ala Lys 
305                 310                 315                 320 


Glu Leu Ser Ala Val His Ser Ser His His Glu Ile Gly Val Asn Asp 
                325                 330                 335     


Ser Asn Leu Phe Ser Leu Glu Met Arg Glu Pro Leu Glu Ser Ser Asn 
            340                 345                 350         


Thr Lys Ser Phe His Ser Ala Val Glu Ile Lys Asn Arg Ser Gln His 
        355                 360                 365             


Glu Leu Pro Cys Phe Gln His His Gly Ile Asp Thr Pro Thr Ser Leu 
    370                 375                 380                 


Gln Lys Arg Ser Ala Cys Cys Pro Pro Ser Leu Leu Arg Leu Glu Glu 
385                 390                 395                 400 


Thr Ala Ser Ser Ser Gln Asp Gly Asp Pro Gln Ile Trp Asp Asp Leu 
                405                 410                 415     


Pro Phe Ser Glu Ser Leu Asn Lys Phe Leu Ala Val Leu Glu Ser Glu 
            420                 425                 430         


Ile Ala Val Thr Gln Ala Asp Val Ser Ser Arg Lys His His Val Asp 
        435                 440                 445             


Asn Asp Ile Asp Lys Phe His Ala Asp His Ser Arg Leu Ser Val Thr 
    450                 455                 460                 


Pro Gln Arg Thr Thr Gly Ala Leu His Thr Pro Pro Ile Ala Leu Arg 
465                 470                 475                 480 


Ser Ser Gln Val Ile Val Lys Ala Asn Cys Ser Lys Asp Asp Phe Leu 
                485                 490                 495     


Phe Asn Cys Lys Gly Asn Leu Ser Pro Ser Val Glu Lys Glu Ser Gln 
            500                 505                 510         


Pro Asp Asn Lys Val Glu Ala Val Ser Val Asn His Asn Gly Arg Asp 
        515                 520                 525             


Met Ser Glu Tyr Phe Leu Pro Asn Pro Tyr Leu Ser Ala Leu Ser Ser 
    530                 535                 540                 


Ser Ser Lys Asp Leu Glu Thr Ile Val Thr Leu Lys Lys Thr Ile Arg 
545                 550                 555                 560 


Ile Ser Pro His Arg Glu Ser Asp His Ser Ser Leu Asn Asn Lys Tyr 
                565                 570                 575     


Leu Asn Gly Cys Gly Glu Ile Ser Val Ser Glu Met Asn Glu Lys Leu 
            580                 585                 590         


Thr Thr Leu Cys Tyr Arg Lys Tyr Asn Asp Val Ser Asp Leu Cys Lys 
        595                 600                 605             


Leu Glu Asn Lys Gln Tyr Cys Arg Trp Ser Lys Asn Gln Asp Asp Ser 
    610                 615                 620                 


Phe Thr Ile Cys Arg Lys Leu Thr Tyr Pro Leu Glu Thr Leu Cys Asn 
625                 630                 635                 640 


Ser Pro Asn Arg Ser Thr Asn Thr Leu Lys Glu Met Pro Trp Gly His 
                645                 650                 655     


Ile Asn Asn Asn Val Thr Gln Ser Tyr Ser Ile Gly Tyr Glu Gly Ser 
            660                 665                 670         


Tyr Asp Ala Ser Ala Asp Leu Phe Asp Asp Ile Ala Lys Glu Met Asp 
        675                 680                 685             


Ile Ala Thr Glu Ile Thr Lys Lys Ser Gln Asp Ile Leu Leu Lys Trp 
    690                 695                 700                 


Gly Thr Ser Leu Ala Glu Ser His Pro Ser Glu Ser Asp Phe Ser Leu 
705                 710                 715                 720 


Arg Ser Leu Ser Glu Asp Phe Ile Gln Pro Ser Gln Lys Leu Ser Leu 
                725                 730                 735     


Gln Ser Leu Ser Asp Ser Arg His Ser Arg Thr Cys Ser Pro Thr Pro 
            740                 745                 750         


His Phe Gln Ser Asp Ser Glu Tyr Asn Phe Glu Asn Ser Gln Asp Phe 
        755                 760                 765             


Val Pro Cys Ser Gln Ser Thr Pro Ile Ser Gly Phe His Gln Thr Arg 
    770                 775                 780                 


Ile His Gly Ile Asn Arg Ala Phe Lys Lys Pro Val Phe Tyr Ser Asp 
785                 790                 795                 800 


Leu Asp Gly Asn Tyr Glu Lys Ile Arg Ile Phe Pro Glu Asn Asp Lys 
                805                 810                 815     


Gln Gln Ala Ser Pro Ser Cys Pro Lys Asn Ile Lys Thr Pro Ser Gln 
            820                 825                 830         


Lys Ile Arg Ser Pro Ile Val Ser Gly Val Ser Gln Pro Asp Val Phe 
        835                 840                 845             


Asn His Tyr Pro Phe Ala Glu Cys His Glu Thr Asp Ser Asp Glu Trp 
    850                 855                 860                 


Val Pro Pro Thr Thr Gln Lys Ile Phe Pro Ser Asp Met Leu Gly Phe 
865                 870                 875                 880 


Gln Gly Ile Gly Leu Gly Lys Cys Leu Ala Ala Tyr His Phe Pro Asp 
                885                 890                 895     


Gln Gln Glu Leu Pro Arg Lys Lys Leu Lys His Ile Arg Gln Gly Thr 
            900                 905                 910         


Asn Lys Gly Leu Ile Lys Lys Lys Leu Lys Asn Met Leu Ala Ala Val 
        915                 920                 925             


Val Thr Lys Lys Lys Thr His Lys Tyr Asn Cys Lys Ser Ser Gly Trp 
    930                 935                 940                 


Ile Ser Lys Cys Pro Asp Ile Gln Val Leu Ala Ala Pro Gln Leu His 
945                 950                 955                 960 


Pro Ile Leu Gly Pro Asp Ser Cys Ser Glu Val Lys Cys Cys Leu Pro 
                965                 970                 975     


Phe Ser Glu Lys Gly Pro Pro Ser Val Cys Glu Thr Arg Ser Ala Trp 
            980                 985                 990         


Ser Pro Glu Leu Phe Ser 
        995             


<210>  4017
<211>  998
<212>  PRT
<213>  Homo Sapiens

<400>  4017

Met Asn Arg Arg Arg Lys Phe Leu Leu Ala Ser Val Leu Ala Leu Gln 
1               5                   10                  15      


Asn Ser Ser Phe Ile Tyr Pro Ser Cys Gln Lys Cys Phe Ser Arg Ile 
            20                  25                  30          


Ile Leu Val Ser Lys Arg Ser Asn Cys Pro Lys Cys Gly Ser Thr Gly 
        35                  40                  45              


Glu Ser Gly Asn Ala Asn Tyr Arg Tyr Lys Leu Ser Leu Lys Val Ala 
    50                  55                  60                  


Glu Ser Asn Lys Leu Phe Val Ile Thr Val Phe Gly Ser Cys Leu Asp 
65                  70                  75                  80  


Thr Phe Phe Gly Leu Thr Ala Thr Gly Leu His Arg Tyr Ile Gln Asp 
                85                  90                  95      


Pro Asn Lys Ile Pro Glu Thr Leu Asp Asn Asp Thr Thr Gln Asn Leu 
            100                 105                 110         


Leu Thr Lys Ala Val Glu Thr Cys Phe Val Gly Gln Ser Phe Ile Phe 
        115                 120                 125             


Gly Val Thr Asn Phe Glu Asn Gln Pro Gly Gln Gly Ser Asp Ala Ser 
    130                 135                 140                 


Asn Phe Leu Gln Gln Cys Ser Asp His Lys Arg Lys Ala Lys Ala Leu 
145                 150                 155                 160 


Val Ala Cys Gln Ile Val Leu Pro Asp Pro Gly Ile Ala Gly Phe Thr 
                165                 170                 175     


Val Ile Asp Tyr Phe His Gln Leu Leu Gln Thr Phe Asn Phe Arg Lys 
            180                 185                 190         


Leu Gln Cys Asp Ser Gln Ala Pro Asn Asn His Leu Leu Ala Leu Asp 
        195                 200                 205             


His Ser Asn Ser Asp Leu Ser Ser Ile Tyr Thr Ser Asp Ser Thr Ser 
    210                 215                 220                 


Asp Phe Phe Lys Ser Cys Ser Lys Asp Thr Phe Ser Lys Phe Trp Gln 
225                 230                 235                 240 


Pro Ser Leu Glu Phe Thr Cys Ile Val Ser Gln Leu Thr Asp Asn Asp 
                245                 250                 255     


Asp Phe Ser Ala Ser Glu Gln Ser Lys Ala Phe Gly Thr Leu Gln Gln 
            260                 265                 270         


Asn Arg Lys Ser Ile Ser Ile Ala Glu Ala Thr Gly Ser Ser Ser Cys 
        275                 280                 285             


His Asp Pro Ile Gln Asp Ser Trp Ser Leu Val Ser Tyr Met Asp Lys 
    290                 295                 300                 


Lys Ser Thr Ala Glu Lys Leu Gly Lys Glu Leu Gly Leu Gln Ala Lys 
305                 310                 315                 320 


Glu Leu Ser Ala Val His Ser Ser His His Glu Ile Gly Val Asn Asp 
                325                 330                 335     


Ser Asn Leu Phe Ser Leu Glu Met Arg Glu Pro Leu Glu Ser Ser Asn 
            340                 345                 350         


Thr Lys Ser Phe His Ser Ala Val Glu Ile Lys Asn Arg Ser Gln His 
        355                 360                 365             


Glu Leu Pro Cys Phe Gln His His Gly Ile Asp Thr Pro Thr Ser Leu 
    370                 375                 380                 


Gln Lys Arg Ser Ala Cys Cys Pro Pro Ser Leu Leu Arg Leu Glu Glu 
385                 390                 395                 400 


Thr Ala Ser Ser Ser Gln Asp Gly Asp Pro Gln Ile Trp Asp Asp Leu 
                405                 410                 415     


Pro Phe Ser Glu Ser Leu Asn Lys Phe Leu Ala Val Leu Glu Ser Glu 
            420                 425                 430         


Ile Ala Val Thr Gln Ala Asp Val Ser Ser Arg Lys His His Val Asp 
        435                 440                 445             


Asn Asp Ile Asp Lys Phe His Ala Asp His Ser Arg Leu Ser Val Thr 
    450                 455                 460                 


Pro Gln Arg Thr Thr Gly Ala Leu His Thr Pro Pro Ile Ala Leu Arg 
465                 470                 475                 480 


Ser Ser Gln Val Ile Val Lys Ala Asn Cys Ser Lys Asp Asp Phe Leu 
                485                 490                 495     


Phe Asn Cys Lys Gly Asn Leu Ser Pro Ser Val Glu Lys Glu Ser Gln 
            500                 505                 510         


Pro Asp Asn Lys Val Glu Ala Val Ser Val Asn His Asn Gly Arg Asp 
        515                 520                 525             


Met Ser Glu Tyr Phe Leu Pro Asn Pro Tyr Leu Ser Ala Leu Ser Ser 
    530                 535                 540                 


Ser Ser Lys Asp Leu Glu Thr Ile Val Thr Leu Lys Lys Thr Ile Arg 
545                 550                 555                 560 


Ile Ser Pro His Arg Glu Ser Asp His Ser Ser Leu Asn Asn Lys Tyr 
                565                 570                 575     


Leu Asn Gly Cys Gly Glu Ile Ser Val Ser Glu Met Asn Glu Lys Leu 
            580                 585                 590         


Thr Thr Leu Cys Tyr Arg Lys Tyr Asn Asp Val Ser Asp Leu Cys Lys 
        595                 600                 605             


Leu Glu Asn Lys Gln Tyr Cys Arg Trp Ser Lys Asn Gln Asp Asp Ser 
    610                 615                 620                 


Phe Thr Ile Cys Arg Lys Leu Thr Tyr Pro Leu Glu Thr Leu Cys Asn 
625                 630                 635                 640 


Ser Pro Asn Arg Ser Thr Asn Thr Leu Lys Glu Met Pro Trp Gly His 
                645                 650                 655     


Ile Asn Asn Asn Val Thr Gln Ser Tyr Ser Ile Gly Tyr Glu Gly Ser 
            660                 665                 670         


Tyr Asp Ala Ser Ala Asp Leu Phe Asp Asp Ile Ala Lys Glu Met Asp 
        675                 680                 685             


Ile Ala Thr Glu Ile Thr Lys Lys Ser Gln Asp Ile Leu Leu Lys Trp 
    690                 695                 700                 


Gly Thr Ser Leu Ala Glu Ser His Pro Ser Glu Ser Asp Phe Ser Leu 
705                 710                 715                 720 


Arg Ser Leu Ser Glu Asp Phe Ile Gln Pro Ser Gln Lys Leu Ser Leu 
                725                 730                 735     


Gln Ser Leu Ser Asp Ser Arg His Ser Arg Thr Cys Ser Pro Thr Pro 
            740                 745                 750         


His Phe Gln Ser Asp Ser Glu Tyr Asn Phe Glu Asn Ser Gln Asp Phe 
        755                 760                 765             


Val Pro Cys Ser Gln Ser Thr Pro Ile Ser Gly Phe His Gln Thr Arg 
    770                 775                 780                 


Ile His Gly Ile Asn Arg Ala Phe Lys Lys Pro Val Phe Tyr Ser Asp 
785                 790                 795                 800 


Leu Asp Gly Asn Tyr Glu Lys Ile Arg Ile Phe Pro Glu Asn Asp Lys 
                805                 810                 815     


Gln Gln Ala Ser Pro Ser Cys Pro Lys Asn Ile Lys Thr Pro Ser Gln 
            820                 825                 830         


Lys Ile Arg Ser Pro Ile Val Ser Gly Val Ser Gln Pro Asp Val Phe 
        835                 840                 845             


Asn His Tyr Pro Phe Ala Glu Cys His Glu Thr Asp Ser Asp Glu Trp 
    850                 855                 860                 


Val Pro Pro Thr Thr Gln Lys Ile Phe Pro Ser Asp Met Leu Gly Phe 
865                 870                 875                 880 


Gln Gly Ile Gly Leu Gly Lys Cys Leu Ala Ala Tyr His Phe Pro Asp 
                885                 890                 895     


Gln Gln Glu Leu Pro Arg Lys Lys Leu Lys His Ile Arg Gln Gly Thr 
            900                 905                 910         


Asn Lys Gly Leu Ile Lys Lys Lys Leu Lys Asn Met Leu Ala Ala Val 
        915                 920                 925             


Val Thr Lys Lys Lys Thr His Lys Tyr Asn Cys Lys Ser Ser Gly Trp 
    930                 935                 940                 


Ile Ser Lys Cys Pro Asp Ile Gln Val Leu Ala Ala Pro Gln Leu His 
945                 950                 955                 960 


Pro Ile Leu Gly Pro Asp Ser Cys Ser Glu Val Lys Cys Cys Leu Pro 
                965                 970                 975     


Phe Ser Glu Lys Gly Pro Pro Ser Val Cys Glu Thr Arg Ser Ala Trp 
            980                 985                 990         


Ser Pro Glu Leu Phe Ser 
        995             


<210>  4018
<211>  225
<212>  PRT
<213>  Homo Sapiens

<400>  4018

Met Tyr Gln Met Ser Thr Leu Lys Ser Asn Lys Val Ile Phe Gln Leu 
1               5                   10                  15      


Lys Lys Asn Asn Phe His Gln Phe Arg Phe Phe Lys Arg Phe Ile Trp 
            20                  25                  30          


Ser Phe Ala Leu Val Ala Gln Ala Glu Val Pro Trp Cys Asn Leu Gly 
        35                  40                  45              


Ser Leu Gln Pro Pro His Pro Arg Pro Arg Cys Glu His Met Asn Arg 
    50                  55                  60                  


Arg Arg Lys Phe Leu Leu Ala Ser Val Leu Ala Leu Gln Asn Ser Ser 
65                  70                  75                  80  


Phe Ile Tyr Pro Ser Cys Gln Lys Cys Phe Ser Arg Ile Ile Leu Val 
                85                  90                  95      


Ser Lys Arg Ser Asn Cys Pro Lys Cys Gly Ser Thr Gly Glu Ser Gly 
            100                 105                 110         


Asn Ala Asn Tyr Arg Tyr Lys Leu Ser Leu Lys Val Ala Glu Ser Asn 
        115                 120                 125             


Lys Leu Phe Val Ile Thr Val Phe Gly Ser Cys Leu Asp Thr Phe Phe 
    130                 135                 140                 


Gly Leu Thr Ala Thr Gly Leu His Arg Tyr Ile Gln Asp Pro Asn Lys 
145                 150                 155                 160 


Ile Pro Glu Thr Leu Asp Asn Asp Thr Thr Gln Asn Leu Leu Thr Lys 
                165                 170                 175     


Ala Val Glu Thr Cys Phe Val Gly Gln Ser Phe Ile Phe Gly Val Thr 
            180                 185                 190         


Asn Phe Glu Asn Gln Pro Gly Gln Gly Ser Asp Ala Ser Asn Phe Leu 
        195                 200                 205             


Gln Gln Cys Ser Asp His Lys Arg Lys Ala Lys Ala Leu Val Ala Cys 
    210                 215                 220                 


Gln 
225 


<210>  4019
<211>  439
<212>  PRT
<213>  Homo Sapiens

<400>  4019

Met Glu Pro Ser Thr Ala Ala Arg Ala Trp Ala Leu Phe Trp Leu Leu 
1               5                   10                  15      


Leu Pro Leu Leu Gly Ala Val Cys Ala Ser Gly Pro Arg Thr Leu Val 
            20                  25                  30          


Leu Leu Asp Asn Leu Asn Val Arg Glu Thr His Ser Leu Phe Phe Arg 
        35                  40                  45              


Ser Leu Lys Asp Arg Gly Phe Glu Leu Thr Phe Lys Thr Ala Asp Asp 
    50                  55                  60                  


Pro Ser Leu Ser Leu Ile Lys Tyr Gly Glu Phe Leu Tyr Asp Asn Leu 
65                  70                  75                  80  


Ile Ile Phe Ser Pro Ser Val Glu Asp Phe Gly Gly Asn Ile Asn Val 
                85                  90                  95      


Glu Thr Ile Ser Ala Phe Ile Asp Gly Gly Gly Ser Val Leu Val Ala 
            100                 105                 110         


Ala Ser Ser Asp Ile Gly Asp Pro Leu Arg Glu Leu Gly Ser Glu Cys 
        115                 120                 125             


Gly Ile Glu Phe Asp Glu Glu Lys Thr Ala Val Ile Asp His His Asn 
    130                 135                 140                 


Tyr Asp Ile Ser Asp Leu Gly Gln His Thr Leu Ile Val Ala Asp Thr 
145                 150                 155                 160 


Glu Asn Leu Leu Lys Ala Pro Thr Ile Val Gly Lys Ser Ser Leu Asn 
                165                 170                 175     


Pro Ile Leu Phe Arg Gly Val Gly Met Val Ala Asp Pro Asp Asn Pro 
            180                 185                 190         


Leu Val Leu Asp Ile Leu Thr Gly Ser Ser Thr Ser Tyr Ser Phe Phe 
        195                 200                 205             


Pro Asp Lys Pro Ile Thr Gln Tyr Pro His Ala Val Gly Lys Asn Thr 
    210                 215                 220                 


Leu Leu Ile Ala Gly Leu Gln Ala Arg Asn Asn Ala Arg Val Ile Phe 
225                 230                 235                 240 


Ser Gly Ser Leu Asp Phe Phe Ser Asp Ser Phe Phe Asn Ser Ala Val 
                245                 250                 255     


Gln Lys Ala Ala Pro Gly Ser Gln Arg Tyr Ser Gln Thr Gly Asn Tyr 
            260                 265                 270         


Glu Leu Ala Val Ala Leu Ser Arg Trp Val Phe Lys Glu Glu Gly Val 
        275                 280                 285             


Leu Arg Val Gly Pro Val Ser His His Arg Val Gly Glu Thr Ala Pro 
    290                 295                 300                 


Pro Asn Ala Tyr Thr Val Thr Asp Leu Val Glu Tyr Ser Ile Val Ile 
305                 310                 315                 320 


Gln Gln Leu Ser Asn Gly Lys Trp Val Pro Phe Asp Gly Asp Asp Ile 
                325                 330                 335     


Gln Leu Glu Phe Val Arg Ile Asp Pro Phe Val Arg Thr Phe Leu Lys 
            340                 345                 350         


Lys Lys Gly Gly Lys Tyr Ser Val Gln Phe Lys Leu Pro Asp Val Tyr 
        355                 360                 365             


Gly Val Phe Gln Phe Lys Val Asp Tyr Asn Arg Leu Gly Tyr Thr His 
    370                 375                 380                 


Leu Tyr Ser Ser Thr Gln Val Ser Val Arg Pro Leu Gln His Thr Gln 
385                 390                 395                 400 


Tyr Glu Arg Phe Ile Pro Ser Ala Tyr Pro Tyr Tyr Ala Ser Ala Phe 
                405                 410                 415     


Ser Met Met Leu Gly Leu Phe Ile Phe Ser Ile Val Phe Leu His Met 
            420                 425                 430         


Lys Glu Lys Glu Lys Ser Asp 
        435                 


<210>  4020
<211>  155
<212>  PRT
<213>  Homo Sapiens

<400>  4020

Met Glu Pro Ser Thr Ala Ala Arg Ala Trp Ala Leu Phe Trp Leu Leu 
1               5                   10                  15      


Leu Pro Leu Leu Gly Ala Val Cys Ala Ser Gly Pro Arg Thr Leu Val 
            20                  25                  30          


Leu Leu Asp Asn Leu Asn Val Arg Glu Thr His Ser Leu Phe Phe Arg 
        35                  40                  45              


Ser Leu Lys Asp Arg Gly Phe Glu Leu Thr Phe Lys Thr Ala Asp Asp 
    50                  55                  60                  


Pro Ser Leu Ser Leu Ile Lys Tyr Gly Glu Phe Leu Tyr Asp Asn Leu 
65                  70                  75                  80  


Ile Ile Phe Ser Pro Ser Val Glu Gly Asp Pro Leu Arg Glu Leu Gly 
                85                  90                  95      


Ser Glu Cys Gly Ile Glu Phe Asp Glu Glu Lys Thr Ala Val Ile Asp 
            100                 105                 110         


His His Asn Tyr Asp Ile Ser Asp Leu Gly Gln His Thr Leu Ile Val 
        115                 120                 125             


Ala Asp Thr Glu Asn Leu Leu Lys Ala Pro Thr Ile Val Gly Lys Ser 
    130                 135                 140                 


Ser Leu Asn Pro Ile Leu Phe Arg Gly Val Gly 
145                 150                 155 


<210>  4021
<211>  456
<212>  PRT
<213>  Homo Sapiens

<400>  4021

Met Gly Tyr Phe Arg Cys Ala Arg Ala Gly Ser Phe Gly Arg Arg Arg 
1               5                   10                  15      


Lys Met Glu Pro Ser Thr Ala Ala Arg Ala Trp Ala Leu Phe Trp Leu 
            20                  25                  30          


Leu Leu Pro Leu Leu Gly Ala Val Cys Ala Ser Gly Pro Arg Thr Leu 
        35                  40                  45              


Val Leu Leu Asp Asn Leu Asn Val Arg Glu Thr His Ser Leu Phe Phe 
    50                  55                  60                  


Arg Ser Leu Lys Asp Arg Gly Phe Glu Leu Thr Phe Lys Thr Ala Asp 
65                  70                  75                  80  


Asp Pro Ser Leu Ser Leu Ile Lys Tyr Gly Glu Phe Leu Tyr Asp Asn 
                85                  90                  95      


Leu Ile Ile Phe Ser Pro Ser Val Glu Asp Phe Gly Gly Asn Ile Asn 
            100                 105                 110         


Val Glu Thr Ile Ser Ala Phe Ile Asp Gly Gly Gly Ser Val Leu Val 
        115                 120                 125             


Ala Ala Ser Ser Asp Ile Gly Asp Pro Leu Arg Glu Leu Gly Ser Glu 
    130                 135                 140                 


Cys Gly Ile Glu Phe Asp Glu Glu Lys Thr Ala Val Ile Asp His His 
145                 150                 155                 160 


Asn Tyr Asp Ile Ser Asp Leu Gly Gln His Thr Leu Ile Val Ala Asp 
                165                 170                 175     


Thr Glu Asn Leu Leu Lys Ala Pro Thr Ile Val Gly Lys Ser Ser Leu 
            180                 185                 190         


Asn Pro Ile Leu Phe Arg Gly Val Gly Met Val Ala Asp Pro Asp Asn 
        195                 200                 205             


Pro Leu Val Leu Asp Ile Leu Thr Gly Ser Ser Thr Ser Tyr Ser Phe 
    210                 215                 220                 


Phe Pro Asp Lys Pro Ile Thr Gln Tyr Pro His Ala Val Gly Lys Asn 
225                 230                 235                 240 


Thr Leu Leu Ile Ala Gly Leu Gln Ala Arg Asn Asn Ala Arg Val Ile 
                245                 250                 255     


Phe Ser Gly Ser Leu Asp Phe Phe Ser Asp Ser Phe Phe Asn Ser Ala 
            260                 265                 270         


Val Gln Lys Ala Ala Pro Gly Ser Gln Arg Tyr Ser Gln Thr Gly Asn 
        275                 280                 285             


Tyr Glu Leu Ala Val Ala Leu Ser Arg Trp Val Phe Lys Glu Glu Gly 
    290                 295                 300                 


Val Leu Arg Val Gly Pro Val Ser His His Arg Val Gly Glu Thr Ala 
305                 310                 315                 320 


Pro Pro Asn Ala Tyr Thr Val Thr Asp Leu Val Glu Tyr Ser Ile Val 
                325                 330                 335     


Ile Gln Gln Leu Ser Asn Gly Lys Trp Val Pro Phe Asp Gly Asp Asp 
            340                 345                 350         


Ile Gln Leu Glu Phe Val Arg Ile Asp Pro Phe Val Arg Thr Phe Leu 
        355                 360                 365             


Lys Lys Lys Gly Gly Lys Tyr Ser Val Gln Phe Lys Leu Pro Asp Val 
    370                 375                 380                 


Tyr Gly Val Phe Gln Phe Lys Val Asp Tyr Asn Arg Leu Gly Tyr Thr 
385                 390                 395                 400 


His Leu Tyr Ser Ser Thr Gln Val Ser Val Arg Pro Leu Gln His Thr 
                405                 410                 415     


Gln Tyr Glu Arg Phe Ile Pro Ser Ala Tyr Pro Tyr Tyr Ala Ser Ala 
            420                 425                 430         


Phe Ser Met Met Leu Gly Leu Phe Ile Phe Ser Ile Val Phe Leu His 
        435                 440                 445             


Met Lys Glu Lys Glu Lys Ser Asp 
    450                 455     


<210>  4022
<211>  456
<212>  PRT
<213>  Homo Sapiens

<400>  4022

Met Gly Tyr Phe Arg Cys Ala Arg Ala Gly Ser Phe Gly Arg Arg Arg 
1               5                   10                  15      


Lys Met Glu Pro Ser Thr Ala Ala Arg Ala Trp Ala Leu Phe Trp Leu 
            20                  25                  30          


Leu Leu Pro Leu Leu Gly Ala Val Cys Ala Ser Gly Pro Arg Thr Leu 
        35                  40                  45              


Val Leu Leu Asp Asn Leu Asn Val Arg Glu Thr His Ser Leu Phe Phe 
    50                  55                  60                  


Arg Ser Leu Lys Asp Arg Gly Phe Glu Leu Thr Phe Lys Thr Ala Asp 
65                  70                  75                  80  


Asp Pro Ser Leu Ser Leu Ile Lys Tyr Gly Glu Phe Leu Tyr Asp Asn 
                85                  90                  95      


Leu Ile Ile Phe Ser Pro Ser Val Glu Asp Phe Gly Gly Asn Ile Asn 
            100                 105                 110         


Val Glu Thr Ile Ser Ala Phe Ile Asp Gly Gly Gly Ser Val Leu Val 
        115                 120                 125             


Ala Ala Ser Ser Asp Ile Gly Asp Pro Leu Arg Glu Leu Gly Ser Glu 
    130                 135                 140                 


Cys Gly Ile Glu Phe Asp Glu Glu Lys Thr Ala Val Ile Asp His His 
145                 150                 155                 160 


Asn Tyr Asp Ile Ser Asp Leu Gly Gln His Thr Leu Ile Val Ala Asp 
                165                 170                 175     


Thr Glu Asn Leu Leu Lys Ala Pro Thr Ile Val Gly Lys Ser Ser Leu 
            180                 185                 190         


Asn Pro Ile Leu Phe Arg Gly Val Gly Met Val Ala Asp Pro Asp Asn 
        195                 200                 205             


Pro Leu Val Leu Asp Ile Leu Thr Gly Ser Ser Thr Ser Tyr Ser Phe 
    210                 215                 220                 


Phe Pro Asp Lys Pro Ile Thr Gln Tyr Pro His Ala Val Gly Lys Asn 
225                 230                 235                 240 


Thr Leu Leu Ile Ala Gly Leu Gln Ala Arg Asn Asn Ala Arg Val Ile 
                245                 250                 255     


Phe Ser Gly Ser Leu Asp Phe Phe Ser Asp Ser Phe Phe Asn Ser Ala 
            260                 265                 270         


Val Gln Lys Ala Ala Pro Gly Ser Gln Arg Tyr Ser Gln Thr Gly Asn 
        275                 280                 285             


Tyr Glu Leu Ala Val Ala Leu Ser Arg Trp Val Phe Lys Glu Glu Gly 
    290                 295                 300                 


Val Leu Arg Val Gly Pro Val Ser His His Arg Val Gly Glu Thr Ala 
305                 310                 315                 320 


Pro Pro Asn Ala Tyr Thr Val Thr Asp Leu Val Glu Tyr Ser Ile Val 
                325                 330                 335     


Ile Gln Gln Leu Ser Asn Gly Lys Trp Val Pro Phe Asp Gly Asp Asp 
            340                 345                 350         


Ile Gln Leu Glu Phe Val Arg Ile Asp Pro Phe Val Arg Thr Phe Leu 
        355                 360                 365             


Lys Lys Lys Gly Gly Lys Tyr Ser Val Gln Phe Lys Leu Pro Asp Val 
    370                 375                 380                 


Tyr Gly Val Phe Gln Phe Lys Val Asp Tyr Asn Arg Leu Gly Tyr Thr 
385                 390                 395                 400 


His Leu Tyr Ser Ser Thr Gln Val Ser Val Arg Pro Leu Gln His Thr 
                405                 410                 415     


Gln Tyr Glu Arg Phe Ile Pro Ser Ala Tyr Pro Tyr Tyr Ala Ser Ala 
            420                 425                 430         


Phe Ser Met Met Leu Gly Leu Phe Ile Phe Ser Ile Val Phe Leu His 
        435                 440                 445             


Met Lys Glu Lys Glu Lys Ser Asp 
    450                 455     


<210>  4023
<211>  41
<212>  PRT
<213>  Homo Sapiens

<400>  4023

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr 
        35                  40      


<210>  4024
<211>  51
<212>  PRT
<213>  Homo Sapiens

<400>  4024

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser 
    50      


<210>  4025
<211>  51
<212>  PRT
<213>  Homo Sapiens

<400>  4025

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser 
    50      


<210>  4026
<211>  55
<212>  PRT
<213>  Homo Sapiens

<400>  4026

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp 
    50                  55  


<210>  4027
<211>  58
<212>  PRT
<213>  Homo Sapiens

<400>  4027

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala 
    50                  55              


<210>  4028
<211>  70
<212>  PRT
<213>  Homo Sapiens

<400>  4028

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp 
65                  70  


<210>  4029
<211>  73
<212>  PRT
<213>  Homo Sapiens

<400>  4029

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp 
65                  70              


<210>  4030
<211>  78
<212>  PRT
<213>  Homo Sapiens

<400>  4030

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser 
65                  70                  75              


<210>  4031
<211>  85
<212>  PRT
<213>  Homo Sapiens

<400>  4031

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu 
                85  


<210>  4032
<211>  101
<212>  PRT
<213>  Homo Sapiens

<400>  4032

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly 
            100     


<210>  4033
<211>  112
<212>  PRT
<213>  Homo Sapiens

<400>  4033

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


<210>  4034
<211>  115
<212>  PRT
<213>  Homo Sapiens

<400>  4034

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser 
        115 


<210>  4035
<211>  122
<212>  PRT
<213>  Homo Sapiens

<400>  4035

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr 
        115                 120         


<210>  4036
<211>  127
<212>  PRT
<213>  Homo Sapiens

<400>  4036

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg 
        115                 120                 125         


<210>  4037
<211>  132
<212>  PRT
<213>  Homo Sapiens

<400>  4037

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg 
        115                 120                 125             


Trp Met Gly Trp 
    130         


<210>  4038
<211>  138
<212>  PRT
<213>  Homo Sapiens

<400>  4038

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg 
        115                 120                 125             


Trp Met Gly Trp Lys Asp Arg Trp Gly Gln 
    130                 135             


<210>  4039
<211>  138
<212>  PRT
<213>  Homo Sapiens

<400>  4039

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg 
        115                 120                 125             


Trp Met Gly Trp Lys Asp Arg Trp Gly Gln 
    130                 135             


<210>  4040
<211>  143
<212>  PRT
<213>  Homo Sapiens

<400>  4040

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg 
        115                 120                 125             


Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly 
    130                 135                 140             


<210>  4041
<211>  147
<212>  PRT
<213>  Homo Sapiens

<400>  4041

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg 
        115                 120                 125             


Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn 
    130                 135                 140                 


Glu Asp Pro 
145         


<210>  4042
<211>  153
<212>  PRT
<213>  Homo Sapiens

<400>  4042

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg 
        115                 120                 125             


Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn 
    130                 135                 140                 


Glu Asp Pro Glu Gly Val Val Leu Lys 
145                 150             


<210>  4043
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  4043

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg 
        115                 120                 125             


Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn 
    130                 135                 140                 


Glu Asp Pro Glu Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met Val 
145                 150                 155                 160 


<210>  4044
<211>  170
<212>  PRT
<213>  Homo Sapiens

<400>  4044

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg 
        115                 120                 125             


Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn 
    130                 135                 140                 


Glu Asp Pro Glu Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met Val 
145                 150                 155                 160 


Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala 
                165                 170 


<210>  4045
<211>  243
<212>  PRT
<213>  Homo Sapiens

<400>  4045

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg 
        115                 120                 125             


Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn 
    130                 135                 140                 


Glu Asp Pro Glu Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met Val 
145                 150                 155                 160 


Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Val Met Ser Val 
                165                 170                 175     


Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Cys Ser Met 
            180                 185                 190         


Gly Val Trp Ala Ser Trp Gln Met Val Trp Trp Gly Trp Met Thr Leu 
        195                 200                 205             


Gly Arg Val Arg Ser Cys Gly Ser Gly Gln Ala Met Thr Met Trp Asp 
    210                 215                 220                 


Gly Ala Thr Thr Ala Ser Pro Val Ala Met Trp Arg Trp Ser Leu Ser 
225                 230                 235                 240 


Leu Thr Gly 
            


<210>  4046
<211>  243
<212>  PRT
<213>  Homo Sapiens

<400>  4046

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg 
        115                 120                 125             


Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn 
    130                 135                 140                 


Glu Asp Pro Glu Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met Val 
145                 150                 155                 160 


Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Val Met Ser Val 
                165                 170                 175     


Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Cys Ser Met 
            180                 185                 190         


Gly Val Trp Ala Ser Trp Gln Met Val Trp Trp Gly Trp Met Thr Leu 
        195                 200                 205             


Gly Arg Val Arg Ser Cys Gly Ser Gly Gln Ala Met Thr Met Trp Asp 
    210                 215                 220                 


Gly Ala Thr Thr Ala Ser Pro Val Ala Met Trp Arg Trp Ser Leu Ser 
225                 230                 235                 240 


Leu Thr Gly 
            


<210>  4047
<211>  209
<212>  PRT
<213>  Homo Sapiens

<400>  4047

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg 
        115                 120                 125             


Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn 
    130                 135                 140                 


Glu Asp Pro Glu Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met Val 
145                 150                 155                 160 


Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Val Met Ser Val 
                165                 170                 175     


Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Gly Leu Leu 
            180                 185                 190         


Ser Tyr Thr Ala Pro Val Gly Gln Thr Met Tyr Leu Ser Glu Ala Val 
        195                 200                 205             


Tyr 
    


<210>  4048
<211>  913
<212>  PRT
<213>  Homo Sapiens

<400>  4048

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg 
        115                 120                 125             


Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn 
    130                 135                 140                 


Glu Asp Pro Glu Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met Val 
145                 150                 155                 160 


Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Val Met Ser Val 
                165                 170                 175     


Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Gly Leu Leu 
            180                 185                 190         


Ser Tyr Thr Ala Pro Val Gly Gln Thr Met Tyr Leu Ser Glu Ala Val 
        195                 200                 205             


Tyr Leu Asn Asp Ser Thr Tyr Asp Gly His Thr Val Gly Gly Leu Gln 
    210                 215                 220                 


Tyr Gly Gly Leu Gly Gln Leu Ala Asp Gly Val Val Gly Leu Asp Asp 
225                 230                 235                 240 


Phe Arg Lys Ser Gln Glu Leu Arg Val Trp Pro Gly Tyr Asp Tyr Val 
                245                 250                 255     


Gly Trp Ser Asn His Ser Phe Ser Ser Gly Tyr Val Glu Met Glu Phe 
            260                 265                 270         


Glu Phe Asp Arg Leu Arg Ala Phe Gln Ala Met Gln Val His Cys Asn 
        275                 280                 285             


Asn Met His Thr Leu Gly Ala Arg Leu Pro Gly Gly Val Glu Cys Arg 
    290                 295                 300                 


Phe Arg Arg Gly Pro Ala Met Ala Trp Glu Gly Glu Pro Met Arg His 
305                 310                 315                 320 


Asn Leu Gly Gly Asn Leu Gly Asp Pro Arg Ala Arg Ala Val Ser Val 
                325                 330                 335     


Pro Leu Gly Gly Arg Val Ala Arg Phe Leu Gln Cys Arg Phe Leu Phe 
            340                 345                 350         


Ala Gly Pro Trp Leu Leu Phe Ser Glu Ile Ser Phe Ile Ser Asp Val 
        355                 360                 365             


Val Asn Asn Ser Ser Pro Ala Leu Gly Gly Thr Phe Pro Pro Ala Pro 
    370                 375                 380                 


Trp Trp Pro Pro Gly Pro Pro Pro Thr Asn Phe Ser Ser Leu Glu Leu 
385                 390                 395                 400 


Glu Pro Arg Gly Gln Gln Pro Val Ala Lys Ala Glu Gly Ser Pro Thr 
                405                 410                 415     


Ala Ile Leu Ile Gly Cys Leu Val Ala Ile Ile Leu Leu Leu Leu Leu 
            420                 425                 430         


Ile Ile Ala Leu Met Leu Trp Arg Leu His Trp Arg Arg Leu Leu Ser 
        435                 440                 445             


Lys Ala Glu Arg Arg Val Leu Glu Glu Glu Leu Thr Val His Leu Ser 
    450                 455                 460                 


Val Pro Gly Asp Thr Ile Leu Ile Asn Asn Arg Pro Gly Pro Arg Glu 
465                 470                 475                 480 


Pro Pro Pro Tyr Gln Glu Pro Arg Pro Arg Gly Asn Pro Pro His Ser 
                485                 490                 495     


Ala Pro Cys Val Pro Asn Gly Ser Ala Leu Leu Leu Ser Asn Pro Ala 
            500                 505                 510         


Tyr Arg Leu Leu Leu Ala Thr Tyr Ala Arg Pro Pro Arg Gly Pro Gly 
        515                 520                 525             


Pro Pro Thr Pro Ala Trp Ala Lys Pro Thr Asn Thr Gln Ala Tyr Ser 
    530                 535                 540                 


Gly Asp Tyr Met Glu Pro Glu Lys Pro Gly Ala Pro Leu Leu Pro Pro 
545                 550                 555                 560 


Pro Pro Gln Asn Ser Val Pro His Tyr Ala Glu Ala Asp Ile Val Thr 
                565                 570                 575     


Leu Gln Gly Val Thr Gly Gly Asn Thr Tyr Ala Val Pro Ala Leu Pro 
            580                 585                 590         


Pro Gly Ala Val Gly Asp Gly Pro Pro Arg Val Asp Phe Pro Arg Ser 
        595                 600                 605             


Arg Leu Arg Phe Lys Glu Lys Leu Gly Glu Gly Gln Phe Gly Glu Val 
    610                 615                 620                 


His Leu Cys Glu Val Asp Ser Pro Gln Asp Leu Val Ser Leu Asp Phe 
625                 630                 635                 640 


Pro Leu Asn Val Arg Lys Gly His Pro Leu Leu Val Ala Val Lys Ile 
                645                 650                 655     


Leu Arg Pro Asp Ala Thr Lys Asn Ala Arg Asn Asp Phe Leu Lys Glu 
            660                 665                 670         


Val Lys Ile Met Ser Arg Leu Lys Asp Pro Asn Ile Ile Arg Leu Leu 
        675                 680                 685             


Gly Val Cys Val Gln Asp Asp Pro Leu Cys Met Ile Thr Asp Tyr Met 
    690                 695                 700                 


Glu Asn Gly Asp Leu Asn Gln Phe Leu Ser Ala His Gln Leu Glu Asp 
705                 710                 715                 720 


Lys Ala Ala Glu Gly Ala Pro Gly Asp Gly Gln Ala Ala Gln Gly Pro 
                725                 730                 735     


Thr Ile Ser Tyr Pro Met Leu Leu His Val Ala Ala Gln Ile Ala Ser 
            740                 745                 750         


Gly Met Arg Tyr Leu Ala Thr Leu Asn Phe Val His Arg Asp Leu Ala 
        755                 760                 765             


Thr Arg Asn Cys Leu Val Gly Glu Asn Phe Thr Ile Lys Ile Ala Asp 
    770                 775                 780                 


Phe Gly Met Ser Arg Asn Leu Tyr Ala Gly Asp Tyr Tyr Arg Val Gln 
785                 790                 795                 800 


Gly Arg Ala Val Leu Pro Ile Arg Trp Met Ala Trp Glu Cys Ile Leu 
                805                 810                 815     


Met Gly Lys Phe Thr Thr Ala Ser Asp Val Trp Ala Phe Gly Val Thr 
            820                 825                 830         


Leu Trp Glu Val Leu Met Leu Cys Arg Ala Gln Pro Phe Gly Gln Leu 
        835                 840                 845             


Thr Asp Glu Gln Val Ile Glu Asn Ala Gly Glu Phe Phe Arg Asp Gln 
    850                 855                 860                 


Gly Arg Gln Val Tyr Leu Ser Arg Pro Pro Ala Cys Pro Gln Gly Leu 
865                 870                 875                 880 


Tyr Glu Leu Met Leu Arg Cys Trp Ser Arg Glu Ser Glu Gln Arg Pro 
                885                 890                 895     


Pro Phe Ser Gln Leu His Arg Phe Leu Ala Glu Asp Ala Leu Asn Thr 
            900                 905                 910         


Val 
    


<210>  4049
<211>  876
<212>  PRT
<213>  Homo Sapiens

<400>  4049

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg 
        115                 120                 125             


Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn 
    130                 135                 140                 


Glu Asp Pro Glu Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met Val 
145                 150                 155                 160 


Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Val Met Ser Val 
                165                 170                 175     


Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Gly Leu Leu 
            180                 185                 190         


Ser Tyr Thr Ala Pro Val Gly Gln Thr Met Tyr Leu Ser Glu Ala Val 
        195                 200                 205             


Tyr Leu Asn Asp Ser Thr Tyr Asp Gly His Thr Val Gly Gly Leu Gln 
    210                 215                 220                 


Tyr Gly Gly Leu Gly Gln Leu Ala Asp Gly Val Val Gly Leu Asp Asp 
225                 230                 235                 240 


Phe Arg Lys Ser Gln Glu Leu Arg Val Trp Pro Gly Tyr Asp Tyr Val 
                245                 250                 255     


Gly Trp Ser Asn His Ser Phe Ser Ser Gly Tyr Val Glu Met Glu Phe 
            260                 265                 270         


Glu Phe Asp Arg Leu Arg Ala Phe Gln Ala Met Gln Val His Cys Asn 
        275                 280                 285             


Asn Met His Thr Leu Gly Ala Arg Leu Pro Gly Gly Val Glu Cys Arg 
    290                 295                 300                 


Phe Arg Arg Gly Pro Ala Met Ala Trp Glu Gly Glu Pro Met Arg His 
305                 310                 315                 320 


Asn Leu Gly Gly Asn Leu Gly Asp Pro Arg Ala Arg Ala Val Ser Val 
                325                 330                 335     


Pro Leu Gly Gly Arg Val Ala Arg Phe Leu Gln Cys Arg Phe Leu Phe 
            340                 345                 350         


Ala Gly Pro Trp Leu Leu Phe Ser Glu Ile Ser Phe Ile Ser Asp Val 
        355                 360                 365             


Val Asn Asn Ser Ser Pro Ala Leu Gly Gly Thr Phe Pro Pro Ala Pro 
    370                 375                 380                 


Trp Trp Pro Pro Gly Pro Pro Pro Thr Asn Phe Ser Ser Leu Glu Leu 
385                 390                 395                 400 


Glu Pro Arg Gly Gln Gln Pro Val Ala Lys Ala Glu Gly Ser Pro Thr 
                405                 410                 415     


Ala Ile Leu Ile Gly Cys Leu Val Ala Ile Ile Leu Leu Leu Leu Leu 
            420                 425                 430         


Ile Ile Ala Leu Met Leu Trp Arg Leu His Trp Arg Arg Leu Leu Ser 
        435                 440                 445             


Lys Ala Glu Arg Arg Val Leu Glu Glu Glu Leu Thr Val His Leu Ser 
    450                 455                 460                 


Val Pro Gly Asp Thr Ile Leu Ile Asn Asn Arg Pro Gly Pro Arg Glu 
465                 470                 475                 480 


Pro Pro Pro Tyr Gln Glu Pro Arg Pro Arg Gly Asn Pro Pro His Ser 
                485                 490                 495     


Ala Pro Cys Val Pro Asn Gly Ser Ala Tyr Ser Gly Asp Tyr Met Glu 
            500                 505                 510         


Pro Glu Lys Pro Gly Ala Pro Leu Leu Pro Pro Pro Pro Gln Asn Ser 
        515                 520                 525             


Val Pro His Tyr Ala Glu Ala Asp Ile Val Thr Leu Gln Gly Val Thr 
    530                 535                 540                 


Gly Gly Asn Thr Tyr Ala Val Pro Ala Leu Pro Pro Gly Ala Val Gly 
545                 550                 555                 560 


Asp Gly Pro Pro Arg Val Asp Phe Pro Arg Ser Arg Leu Arg Phe Lys 
                565                 570                 575     


Glu Lys Leu Gly Glu Gly Gln Phe Gly Glu Val His Leu Cys Glu Val 
            580                 585                 590         


Asp Ser Pro Gln Asp Leu Val Ser Leu Asp Phe Pro Leu Asn Val Arg 
        595                 600                 605             


Lys Gly His Pro Leu Leu Val Ala Val Lys Ile Leu Arg Pro Asp Ala 
    610                 615                 620                 


Thr Lys Asn Ala Arg Asn Asp Phe Leu Lys Glu Val Lys Ile Met Ser 
625                 630                 635                 640 


Arg Leu Lys Asp Pro Asn Ile Ile Arg Leu Leu Gly Val Cys Val Gln 
                645                 650                 655     


Asp Asp Pro Leu Cys Met Ile Thr Asp Tyr Met Glu Asn Gly Asp Leu 
            660                 665                 670         


Asn Gln Phe Leu Ser Ala His Gln Leu Glu Asp Lys Ala Ala Glu Gly 
        675                 680                 685             


Ala Pro Gly Asp Gly Gln Ala Ala Gln Gly Pro Thr Ile Ser Tyr Pro 
    690                 695                 700                 


Met Leu Leu His Val Ala Ala Gln Ile Ala Ser Gly Met Arg Tyr Leu 
705                 710                 715                 720 


Ala Thr Leu Asn Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu 
                725                 730                 735     


Val Gly Glu Asn Phe Thr Ile Lys Ile Ala Asp Phe Gly Met Ser Arg 
            740                 745                 750         


Asn Leu Tyr Ala Gly Asp Tyr Tyr Arg Val Gln Gly Arg Ala Val Leu 
        755                 760                 765             


Pro Ile Arg Trp Met Ala Trp Glu Cys Ile Leu Met Gly Lys Phe Thr 
    770                 775                 780                 


Thr Ala Ser Asp Val Trp Ala Phe Gly Val Thr Leu Trp Glu Val Leu 
785                 790                 795                 800 


Met Leu Cys Arg Ala Gln Pro Phe Gly Gln Leu Thr Asp Glu Gln Val 
                805                 810                 815     


Ile Glu Asn Ala Gly Glu Phe Phe Arg Asp Gln Gly Arg Gln Val Tyr 
            820                 825                 830         


Leu Ser Arg Pro Pro Ala Cys Pro Gln Gly Leu Tyr Glu Leu Met Leu 
        835                 840                 845             


Arg Cys Trp Ser Arg Glu Ser Glu Gln Arg Pro Pro Phe Ser Gln Leu 
    850                 855                 860                 


His Arg Phe Leu Ala Glu Asp Ala Leu Asn Thr Val 
865                 870                 875     


<210>  4050
<211>  876
<212>  PRT
<213>  Homo Sapiens

<400>  4050

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg 
        115                 120                 125             


Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn 
    130                 135                 140                 


Glu Asp Pro Glu Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met Val 
145                 150                 155                 160 


Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Val Met Ser Val 
                165                 170                 175     


Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Gly Leu Leu 
            180                 185                 190         


Ser Tyr Thr Ala Pro Val Gly Gln Thr Met Tyr Leu Ser Glu Ala Val 
        195                 200                 205             


Tyr Leu Asn Asp Ser Thr Tyr Asp Gly His Thr Val Gly Gly Leu Gln 
    210                 215                 220                 


Tyr Gly Gly Leu Gly Gln Leu Ala Asp Gly Val Val Gly Leu Asp Asp 
225                 230                 235                 240 


Phe Arg Lys Ser Gln Glu Leu Arg Val Trp Pro Gly Tyr Asp Tyr Val 
                245                 250                 255     


Gly Trp Ser Asn His Ser Phe Ser Ser Gly Tyr Val Glu Met Glu Phe 
            260                 265                 270         


Glu Phe Asp Arg Leu Arg Ala Phe Gln Ala Met Gln Val His Cys Asn 
        275                 280                 285             


Asn Met His Thr Leu Gly Ala Arg Leu Pro Gly Gly Val Glu Cys Arg 
    290                 295                 300                 


Phe Arg Arg Gly Pro Ala Met Ala Trp Glu Gly Glu Pro Met Arg His 
305                 310                 315                 320 


Asn Leu Gly Gly Asn Leu Gly Asp Pro Arg Ala Arg Ala Val Ser Val 
                325                 330                 335     


Pro Leu Gly Gly Arg Val Ala Arg Phe Leu Gln Cys Arg Phe Leu Phe 
            340                 345                 350         


Ala Gly Pro Trp Leu Leu Phe Ser Glu Ile Ser Phe Ile Ser Asp Val 
        355                 360                 365             


Val Asn Asn Ser Ser Pro Ala Leu Gly Gly Thr Phe Pro Pro Ala Pro 
    370                 375                 380                 


Trp Trp Pro Pro Gly Pro Pro Pro Thr Asn Phe Ser Ser Leu Glu Leu 
385                 390                 395                 400 


Glu Pro Arg Gly Gln Gln Pro Val Ala Lys Ala Glu Gly Ser Pro Thr 
                405                 410                 415     


Ala Ile Leu Ile Gly Cys Leu Val Ala Ile Ile Leu Leu Leu Leu Leu 
            420                 425                 430         


Ile Ile Ala Leu Met Leu Trp Arg Leu His Trp Arg Arg Leu Leu Ser 
        435                 440                 445             


Lys Ala Glu Arg Arg Val Leu Glu Glu Glu Leu Thr Val His Leu Ser 
    450                 455                 460                 


Val Pro Gly Asp Thr Ile Leu Ile Asn Asn Arg Pro Gly Pro Arg Glu 
465                 470                 475                 480 


Pro Pro Pro Tyr Gln Glu Pro Arg Pro Arg Gly Asn Pro Pro His Ser 
                485                 490                 495     


Ala Pro Cys Val Pro Asn Gly Ser Ala Tyr Ser Gly Asp Tyr Met Glu 
            500                 505                 510         


Pro Glu Lys Pro Gly Ala Pro Leu Leu Pro Pro Pro Pro Gln Asn Ser 
        515                 520                 525             


Val Pro His Tyr Ala Glu Ala Asp Ile Val Thr Leu Gln Gly Val Thr 
    530                 535                 540                 


Gly Gly Asn Thr Tyr Ala Val Pro Ala Leu Pro Pro Gly Ala Val Gly 
545                 550                 555                 560 


Asp Gly Pro Pro Arg Val Asp Phe Pro Arg Ser Arg Leu Arg Phe Lys 
                565                 570                 575     


Glu Lys Leu Gly Glu Gly Gln Phe Gly Glu Val His Leu Cys Glu Val 
            580                 585                 590         


Asp Ser Pro Gln Asp Leu Val Ser Leu Asp Phe Pro Leu Asn Val Arg 
        595                 600                 605             


Lys Gly His Pro Leu Leu Val Ala Val Lys Ile Leu Arg Pro Asp Ala 
    610                 615                 620                 


Thr Lys Asn Ala Arg Asn Asp Phe Leu Lys Glu Val Lys Ile Met Ser 
625                 630                 635                 640 


Arg Leu Lys Asp Pro Asn Ile Ile Arg Leu Leu Gly Val Cys Val Gln 
                645                 650                 655     


Asp Asp Pro Leu Cys Met Ile Thr Asp Tyr Met Glu Asn Gly Asp Leu 
            660                 665                 670         


Asn Gln Phe Leu Ser Ala His Gln Leu Glu Asp Lys Ala Ala Glu Gly 
        675                 680                 685             


Ala Pro Gly Asp Gly Gln Ala Ala Gln Gly Pro Thr Ile Ser Tyr Pro 
    690                 695                 700                 


Met Leu Leu His Val Ala Ala Gln Ile Ala Ser Gly Met Arg Tyr Leu 
705                 710                 715                 720 


Ala Thr Leu Asn Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu 
                725                 730                 735     


Val Gly Glu Asn Phe Thr Ile Lys Ile Ala Asp Phe Gly Met Ser Arg 
            740                 745                 750         


Asn Leu Tyr Ala Gly Asp Tyr Tyr Arg Val Gln Gly Arg Ala Val Leu 
        755                 760                 765             


Pro Ile Arg Trp Met Ala Trp Glu Cys Ile Leu Met Gly Lys Phe Thr 
    770                 775                 780                 


Thr Ala Ser Asp Val Trp Ala Phe Gly Val Thr Leu Trp Glu Val Leu 
785                 790                 795                 800 


Met Leu Cys Arg Ala Gln Pro Phe Gly Gln Leu Thr Asp Glu Gln Val 
                805                 810                 815     


Ile Glu Asn Ala Gly Glu Phe Phe Arg Asp Gln Gly Arg Gln Val Tyr 
            820                 825                 830         


Leu Ser Arg Pro Pro Ala Cys Pro Gln Gly Leu Tyr Glu Leu Met Leu 
        835                 840                 845             


Arg Cys Trp Ser Arg Glu Ser Glu Gln Arg Pro Pro Phe Ser Gln Leu 
    850                 855                 860                 


His Arg Phe Leu Ala Glu Asp Ala Leu Asn Thr Val 
865                 870                 875     


<210>  4051
<211>  913
<212>  PRT
<213>  Homo Sapiens

<400>  4051

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg 
        115                 120                 125             


Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn 
    130                 135                 140                 


Glu Asp Pro Glu Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met Val 
145                 150                 155                 160 


Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Val Met Ser Val 
                165                 170                 175     


Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Gly Leu Leu 
            180                 185                 190         


Ser Tyr Thr Ala Pro Val Gly Gln Thr Met Tyr Leu Ser Glu Ala Val 
        195                 200                 205             


Tyr Leu Asn Asp Ser Thr Tyr Asp Gly His Thr Val Gly Gly Leu Gln 
    210                 215                 220                 


Tyr Gly Gly Leu Gly Gln Leu Ala Asp Gly Val Val Gly Leu Asp Asp 
225                 230                 235                 240 


Phe Arg Lys Ser Gln Glu Leu Arg Val Trp Pro Gly Tyr Asp Tyr Val 
                245                 250                 255     


Gly Trp Ser Asn His Ser Phe Ser Ser Gly Tyr Val Glu Met Glu Phe 
            260                 265                 270         


Glu Phe Asp Arg Leu Arg Ala Phe Gln Ala Met Gln Val His Cys Asn 
        275                 280                 285             


Asn Met His Thr Leu Gly Ala Arg Leu Pro Gly Gly Val Glu Cys Arg 
    290                 295                 300                 


Phe Arg Arg Gly Pro Ala Met Ala Trp Glu Gly Glu Pro Met Arg His 
305                 310                 315                 320 


Asn Leu Gly Gly Asn Leu Gly Asp Pro Arg Ala Arg Ala Val Ser Val 
                325                 330                 335     


Pro Leu Gly Gly Arg Val Ala Arg Phe Leu Gln Cys Arg Phe Leu Phe 
            340                 345                 350         


Ala Gly Pro Trp Leu Leu Phe Ser Glu Ile Ser Phe Ile Ser Asp Val 
        355                 360                 365             


Val Asn Asn Ser Ser Pro Ala Leu Gly Gly Thr Phe Pro Pro Ala Pro 
    370                 375                 380                 


Trp Trp Pro Pro Gly Pro Pro Pro Thr Asn Phe Ser Ser Leu Glu Leu 
385                 390                 395                 400 


Glu Pro Arg Gly Gln Gln Pro Val Ala Lys Ala Glu Gly Ser Pro Thr 
                405                 410                 415     


Ala Ile Leu Ile Gly Cys Leu Val Ala Ile Ile Leu Leu Leu Leu Leu 
            420                 425                 430         


Ile Ile Ala Leu Met Leu Trp Arg Leu His Trp Arg Arg Leu Leu Ser 
        435                 440                 445             


Lys Ala Glu Arg Arg Val Leu Glu Glu Glu Leu Thr Val His Leu Ser 
    450                 455                 460                 


Val Pro Gly Asp Thr Ile Leu Ile Asn Asn Arg Pro Gly Pro Arg Glu 
465                 470                 475                 480 


Pro Pro Pro Tyr Gln Glu Pro Arg Pro Arg Gly Asn Pro Pro His Ser 
                485                 490                 495     


Ala Pro Cys Val Pro Asn Gly Ser Ala Leu Leu Leu Ser Asn Pro Ala 
            500                 505                 510         


Tyr Arg Leu Leu Leu Ala Thr Tyr Ala Arg Pro Pro Arg Gly Pro Gly 
        515                 520                 525             


Pro Pro Thr Pro Ala Trp Ala Lys Pro Thr Asn Thr Gln Ala Tyr Ser 
    530                 535                 540                 


Gly Asp Tyr Met Glu Pro Glu Lys Pro Gly Ala Pro Leu Leu Pro Pro 
545                 550                 555                 560 


Pro Pro Gln Asn Ser Val Pro His Tyr Ala Glu Ala Asp Ile Val Thr 
                565                 570                 575     


Leu Gln Gly Val Thr Gly Gly Asn Thr Tyr Ala Val Pro Ala Leu Pro 
            580                 585                 590         


Pro Gly Ala Val Gly Asp Gly Pro Pro Arg Val Asp Phe Pro Arg Ser 
        595                 600                 605             


Arg Leu Arg Phe Lys Glu Lys Leu Gly Glu Gly Gln Phe Gly Glu Val 
    610                 615                 620                 


His Leu Cys Glu Val Asp Ser Pro Gln Asp Leu Val Ser Leu Asp Phe 
625                 630                 635                 640 


Pro Leu Asn Val Arg Lys Gly His Pro Leu Leu Val Ala Val Lys Ile 
                645                 650                 655     


Leu Arg Pro Asp Ala Thr Lys Asn Ala Arg Asn Asp Phe Leu Lys Glu 
            660                 665                 670         


Val Lys Ile Met Ser Arg Leu Lys Asp Pro Asn Ile Ile Arg Leu Leu 
        675                 680                 685             


Gly Val Cys Val Gln Asp Asp Pro Leu Cys Met Ile Thr Asp Tyr Met 
    690                 695                 700                 


Glu Asn Gly Asp Leu Asn Gln Phe Leu Ser Ala His Gln Leu Glu Asp 
705                 710                 715                 720 


Lys Ala Ala Glu Gly Ala Pro Gly Asp Gly Gln Ala Ala Gln Gly Pro 
                725                 730                 735     


Thr Ile Ser Tyr Pro Met Leu Leu His Val Ala Ala Gln Ile Ala Ser 
            740                 745                 750         


Gly Met Arg Tyr Leu Ala Thr Leu Asn Phe Val His Arg Asp Leu Ala 
        755                 760                 765             


Thr Arg Asn Cys Leu Val Gly Glu Asn Phe Thr Ile Lys Ile Ala Asp 
    770                 775                 780                 


Phe Gly Met Ser Arg Asn Leu Tyr Ala Gly Asp Tyr Tyr Arg Val Gln 
785                 790                 795                 800 


Gly Arg Ala Val Leu Pro Ile Arg Trp Met Ala Trp Glu Cys Ile Leu 
                805                 810                 815     


Met Gly Lys Phe Thr Thr Ala Ser Asp Val Trp Ala Phe Gly Val Thr 
            820                 825                 830         


Leu Trp Glu Val Leu Met Leu Cys Arg Ala Gln Pro Phe Gly Gln Leu 
        835                 840                 845             


Thr Asp Glu Gln Val Ile Glu Asn Ala Gly Glu Phe Phe Arg Asp Gln 
    850                 855                 860                 


Gly Arg Gln Val Tyr Leu Ser Arg Pro Pro Ala Cys Pro Gln Gly Leu 
865                 870                 875                 880 


Tyr Glu Leu Met Leu Arg Cys Trp Ser Arg Glu Ser Glu Gln Arg Pro 
                885                 890                 895     


Pro Phe Ser Gln Leu His Arg Phe Leu Ala Glu Asp Ala Leu Asn Thr 
            900                 905                 910         


Val 
    


<210>  4052
<211>  267
<212>  PRT
<213>  Homo Sapiens

<400>  4052

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg 
        115                 120                 125             


Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn 
    130                 135                 140                 


Glu Asp Pro Glu Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met Val 
145                 150                 155                 160 


Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Val Met Ser Val 
                165                 170                 175     


Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Gly Leu Leu 
            180                 185                 190         


Ser Tyr Thr Ala Pro Val Gly Gln Thr Met Tyr Leu Ser Glu Ala Val 
        195                 200                 205             


Tyr Leu Asn Asp Ser Thr Tyr Asp Gly His Thr Val Gly Gly Leu Gln 
    210                 215                 220                 


Tyr Gly Gly Leu Gly Gln Leu Ala Asp Gly Val Val Gly Leu Asp Asp 
225                 230                 235                 240 


Phe Arg Lys Ser Gln Glu Leu Arg Val Trp Pro Gly Tyr Asp Tyr Val 
                245                 250                 255     


Gly Trp Ser Asn His Ser Phe Ser Ser Gly Tyr 
            260                 265         


<210>  4053
<211>  876
<212>  PRT
<213>  Homo Sapiens

<400>  4053

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg 
        115                 120                 125             


Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn 
    130                 135                 140                 


Glu Asp Pro Glu Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met Val 
145                 150                 155                 160 


Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Val Met Ser Val 
                165                 170                 175     


Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Gly Leu Leu 
            180                 185                 190         


Ser Tyr Thr Ala Pro Val Gly Gln Thr Met Tyr Leu Ser Glu Ala Val 
        195                 200                 205             


Tyr Leu Asn Asp Ser Thr Tyr Asp Gly His Thr Val Gly Gly Leu Gln 
    210                 215                 220                 


Tyr Gly Gly Leu Gly Gln Leu Ala Asp Gly Val Val Gly Leu Asp Asp 
225                 230                 235                 240 


Phe Arg Lys Ser Gln Glu Leu Arg Val Trp Pro Gly Tyr Asp Tyr Val 
                245                 250                 255     


Gly Trp Ser Asn His Ser Phe Ser Ser Gly Tyr Val Glu Met Glu Phe 
            260                 265                 270         


Glu Phe Asp Arg Leu Arg Ala Phe Gln Ala Met Gln Val His Cys Asn 
        275                 280                 285             


Asn Met His Thr Leu Gly Ala Arg Leu Pro Gly Gly Val Glu Cys Arg 
    290                 295                 300                 


Phe Arg Arg Gly Pro Ala Met Ala Trp Glu Gly Glu Pro Met Arg His 
305                 310                 315                 320 


Asn Leu Gly Gly Asn Leu Gly Asp Pro Arg Ala Arg Ala Val Ser Val 
                325                 330                 335     


Pro Leu Gly Gly Arg Val Ala Arg Phe Leu Gln Cys Arg Phe Leu Phe 
            340                 345                 350         


Ala Gly Pro Trp Leu Leu Phe Ser Glu Ile Ser Phe Ile Ser Asp Val 
        355                 360                 365             


Val Asn Asn Ser Ser Pro Ala Leu Gly Gly Thr Phe Pro Pro Ala Pro 
    370                 375                 380                 


Trp Trp Pro Pro Gly Pro Pro Pro Thr Asn Phe Ser Ser Leu Glu Leu 
385                 390                 395                 400 


Glu Pro Arg Gly Gln Gln Pro Val Ala Lys Ala Glu Gly Ser Pro Thr 
                405                 410                 415     


Ala Ile Leu Ile Gly Cys Leu Val Ala Ile Ile Leu Leu Leu Leu Leu 
            420                 425                 430         


Ile Ile Ala Leu Met Leu Trp Arg Leu His Trp Arg Arg Leu Leu Ser 
        435                 440                 445             


Lys Ala Glu Arg Arg Val Leu Glu Glu Glu Leu Thr Val His Leu Ser 
    450                 455                 460                 


Val Pro Gly Asp Thr Ile Leu Ile Asn Asn Arg Pro Gly Pro Arg Glu 
465                 470                 475                 480 


Pro Pro Pro Tyr Gln Glu Pro Arg Pro Arg Gly Asn Pro Pro His Ser 
                485                 490                 495     


Ala Pro Cys Val Pro Asn Gly Ser Ala Tyr Ser Gly Asp Tyr Met Glu 
            500                 505                 510         


Pro Glu Lys Pro Gly Ala Pro Leu Leu Pro Pro Pro Pro Gln Asn Ser 
        515                 520                 525             


Val Pro His Tyr Ala Glu Ala Asp Ile Val Thr Leu Gln Gly Val Thr 
    530                 535                 540                 


Gly Gly Asn Thr Tyr Ala Val Pro Ala Leu Pro Pro Gly Ala Val Gly 
545                 550                 555                 560 


Asp Gly Pro Pro Arg Val Asp Phe Pro Arg Ser Arg Leu Arg Phe Lys 
                565                 570                 575     


Glu Lys Leu Gly Glu Gly Gln Phe Gly Glu Val His Leu Cys Glu Val 
            580                 585                 590         


Asp Ser Pro Gln Asp Leu Val Ser Leu Asp Phe Pro Leu Asn Val Arg 
        595                 600                 605             


Lys Gly His Pro Leu Leu Val Ala Val Lys Ile Leu Arg Pro Asp Ala 
    610                 615                 620                 


Thr Lys Asn Ala Arg Asn Asp Phe Leu Lys Glu Val Lys Ile Met Ser 
625                 630                 635                 640 


Arg Leu Lys Asp Pro Asn Ile Ile Arg Leu Leu Gly Val Cys Val Gln 
                645                 650                 655     


Asp Asp Pro Leu Cys Met Ile Thr Asp Tyr Met Glu Asn Gly Asp Leu 
            660                 665                 670         


Asn Gln Phe Leu Ser Ala His Gln Leu Glu Asp Lys Ala Ala Glu Gly 
        675                 680                 685             


Ala Pro Gly Asp Gly Gln Ala Ala Gln Gly Pro Thr Ile Ser Tyr Pro 
    690                 695                 700                 


Met Leu Leu His Val Ala Ala Gln Ile Ala Ser Gly Met Arg Tyr Leu 
705                 710                 715                 720 


Ala Thr Leu Asn Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu 
                725                 730                 735     


Val Gly Glu Asn Phe Thr Ile Lys Ile Ala Asp Phe Gly Met Ser Arg 
            740                 745                 750         


Asn Leu Tyr Ala Gly Asp Tyr Tyr Arg Val Gln Gly Arg Ala Val Leu 
        755                 760                 765             


Pro Ile Arg Trp Met Ala Trp Glu Cys Ile Leu Met Gly Lys Phe Thr 
    770                 775                 780                 


Thr Ala Ser Asp Val Trp Ala Phe Gly Val Thr Leu Trp Glu Val Leu 
785                 790                 795                 800 


Met Leu Cys Arg Ala Gln Pro Phe Gly Gln Leu Thr Asp Glu Gln Val 
                805                 810                 815     


Ile Glu Asn Ala Gly Glu Phe Phe Arg Asp Gln Gly Arg Gln Val Tyr 
            820                 825                 830         


Leu Ser Arg Pro Pro Ala Cys Pro Gln Gly Leu Tyr Glu Leu Met Leu 
        835                 840                 845             


Arg Cys Trp Ser Arg Glu Ser Glu Gln Arg Pro Pro Phe Ser Gln Leu 
    850                 855                 860                 


His Arg Phe Leu Ala Glu Asp Ala Leu Asn Thr Val 
865                 870                 875     


<210>  4054
<211>  767
<212>  PRT
<213>  Homo Sapiens

<400>  4054

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg 
        115                 120                 125             


Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn 
    130                 135                 140                 


Glu Asp Pro Glu Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met Val 
145                 150                 155                 160 


Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Val Met Ser Val 
                165                 170                 175     


Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Gly Leu Leu 
            180                 185                 190         


Ser Tyr Thr Ala Pro Val Gly Gln Thr Met Tyr Leu Ser Glu Ala Val 
        195                 200                 205             


Tyr Leu Asn Asp Ser Thr Tyr Asp Gly His Thr Val Gly Gly Leu Gln 
    210                 215                 220                 


Tyr Gly Gly Leu Gly Gln Leu Ala Asp Gly Val Val Gly Leu Asp Asp 
225                 230                 235                 240 


Phe Arg Lys Ser Gln Glu Leu Arg Val Trp Pro Gly Tyr Asp Tyr Val 
                245                 250                 255     


Gly Trp Ser Asn His Ser Phe Ser Ser Gly Tyr Val Glu Met Glu Phe 
            260                 265                 270         


Glu Phe Asp Arg Leu Arg Ala Phe Gln Ala Met Gln Val His Cys Asn 
        275                 280                 285             


Asn Met His Thr Leu Gly Ala Arg Leu Pro Gly Gly Val Glu Cys Arg 
    290                 295                 300                 


Phe Arg Arg Gly Pro Ala Met Ala Trp Glu Gly Glu Pro Met Arg His 
305                 310                 315                 320 


Asn Leu Gly Gly Asn Leu Gly Asp Pro Arg Ala Arg Ala Val Ser Val 
                325                 330                 335     


Pro Leu Gly Gly Arg Val Ala Arg Phe Leu Gln Cys Arg Phe Leu Phe 
            340                 345                 350         


Ala Gly Pro Trp Leu Leu Phe Ser Glu Ile Ser Phe Ile Ser Asp Val 
        355                 360                 365             


Val Asn Asn Ser Ser Pro Ala Leu Gly Gly Thr Phe Pro Pro Ala Pro 
    370                 375                 380                 


Trp Trp Pro Pro Gly Pro Pro Pro Thr Asn Phe Ser Ser Leu Glu Leu 
385                 390                 395                 400 


Glu Pro Arg Gly Gln Gln Pro Val Ala Lys Ala Glu Gly Ser Pro Thr 
                405                 410                 415     


Ala Ile Leu Ile Gly Cys Leu Val Ala Ile Ile Leu Leu Leu Leu Leu 
            420                 425                 430         


Ile Ile Ala Leu Met Leu Trp Arg Leu His Trp Arg Arg Leu Leu Ser 
        435                 440                 445             


Lys Val Leu Glu Ser His Pro Arg Thr Arg Ser Pro Gly Leu Val Gly 
    450                 455                 460                 


Ile Arg Pro Thr Pro Leu Pro Val Ser Pro Met Ala Leu Val His Leu 
465                 470                 475                 480 


Cys Glu Val Asp Ser Pro Gln Asp Leu Val Ser Leu Asp Phe Pro Leu 
                485                 490                 495     


Asn Val Arg Lys Gly His Pro Leu Leu Val Ala Val Lys Ile Leu Arg 
            500                 505                 510         


Pro Asp Ala Thr Lys Asn Ala Arg Asn Asp Phe Leu Lys Glu Val Lys 
        515                 520                 525             


Ile Met Ser Arg Leu Lys Asp Pro Asn Ile Ile Arg Leu Leu Gly Val 
    530                 535                 540                 


Cys Val Gln Asp Asp Pro Leu Cys Met Ile Thr Asp Tyr Met Glu Asn 
545                 550                 555                 560 


Gly Asp Leu Asn Gln Phe Leu Ser Ala His Gln Leu Glu Asp Lys Ala 
                565                 570                 575     


Ala Glu Gly Ala Pro Gly Asp Gly Gln Ala Ala Gln Gly Pro Thr Ile 
            580                 585                 590         


Ser Tyr Pro Met Leu Leu His Val Ala Ala Gln Ile Ala Ser Gly Met 
        595                 600                 605             


Arg Tyr Leu Ala Thr Leu Asn Phe Val His Arg Asp Leu Ala Thr Arg 
    610                 615                 620                 


Asn Cys Leu Val Gly Glu Asn Phe Thr Ile Lys Ile Ala Asp Phe Gly 
625                 630                 635                 640 


Met Ser Arg Asn Leu Tyr Ala Gly Asp Tyr Tyr Arg Val Gln Gly Arg 
                645                 650                 655     


Ala Val Leu Pro Ile Arg Trp Met Ala Trp Glu Cys Ile Leu Met Gly 
            660                 665                 670         


Lys Phe Thr Thr Ala Ser Asp Val Trp Ala Phe Gly Val Thr Leu Trp 
        675                 680                 685             


Glu Val Leu Met Leu Cys Arg Ala Gln Pro Phe Gly Gln Leu Thr Asp 
    690                 695                 700                 


Glu Gln Val Ile Glu Asn Ala Gly Glu Phe Phe Arg Asp Gln Gly Arg 
705                 710                 715                 720 


Gln Val Tyr Leu Ser Arg Pro Pro Ala Cys Pro Gln Gly Leu Tyr Glu 
                725                 730                 735     


Leu Met Leu Arg Cys Trp Ser Arg Glu Ser Glu Gln Arg Pro Pro Phe 
            740                 745                 750         


Ser Gln Leu His Arg Phe Leu Ala Glu Asp Ala Leu Asn Thr Val 
        755                 760                 765         


<210>  4055
<211>  876
<212>  PRT
<213>  Homo Sapiens

<400>  4055

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg 
        115                 120                 125             


Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn 
    130                 135                 140                 


Glu Asp Pro Glu Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met Val 
145                 150                 155                 160 


Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Val Met Ser Val 
                165                 170                 175     


Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Gly Leu Leu 
            180                 185                 190         


Ser Tyr Thr Ala Pro Val Gly Gln Thr Met Tyr Leu Ser Glu Ala Val 
        195                 200                 205             


Tyr Leu Asn Asp Ser Thr Tyr Asp Gly His Thr Val Gly Gly Leu Gln 
    210                 215                 220                 


Tyr Gly Gly Leu Gly Gln Leu Ala Asp Gly Val Val Gly Leu Asp Asp 
225                 230                 235                 240 


Phe Arg Lys Ser Gln Glu Leu Arg Val Trp Pro Gly Tyr Asp Tyr Val 
                245                 250                 255     


Gly Trp Ser Asn His Ser Phe Ser Ser Gly Tyr Val Glu Met Glu Phe 
            260                 265                 270         


Glu Phe Asp Arg Leu Arg Ala Phe Gln Ala Met Gln Val His Cys Asn 
        275                 280                 285             


Asn Met His Thr Leu Gly Ala Arg Leu Pro Gly Gly Val Glu Cys Arg 
    290                 295                 300                 


Phe Arg Arg Gly Pro Ala Met Ala Trp Glu Gly Glu Pro Met Arg His 
305                 310                 315                 320 


Asn Leu Gly Gly Asn Leu Gly Asp Pro Arg Ala Arg Ala Val Ser Val 
                325                 330                 335     


Pro Leu Gly Gly Arg Val Ala Arg Phe Leu Gln Cys Arg Phe Leu Phe 
            340                 345                 350         


Ala Gly Pro Trp Leu Leu Phe Ser Glu Ile Ser Phe Ile Ser Asp Val 
        355                 360                 365             


Val Asn Asn Ser Ser Pro Ala Leu Gly Gly Thr Phe Pro Pro Ala Pro 
    370                 375                 380                 


Trp Trp Pro Pro Gly Pro Pro Pro Thr Asn Phe Ser Ser Leu Glu Leu 
385                 390                 395                 400 


Glu Pro Arg Gly Gln Gln Pro Val Ala Lys Ala Glu Gly Ser Pro Thr 
                405                 410                 415     


Ala Ile Leu Ile Gly Cys Leu Val Ala Ile Ile Leu Leu Leu Leu Leu 
            420                 425                 430         


Ile Ile Ala Leu Met Leu Trp Arg Leu His Trp Arg Arg Leu Leu Ser 
        435                 440                 445             


Lys Ala Glu Arg Arg Val Leu Glu Glu Glu Leu Thr Val His Leu Ser 
    450                 455                 460                 


Val Pro Gly Asp Thr Ile Leu Ile Asn Asn Arg Pro Gly Pro Arg Glu 
465                 470                 475                 480 


Pro Pro Pro Tyr Gln Glu Pro Arg Pro Arg Gly Asn Pro Pro His Ser 
                485                 490                 495     


Ala Pro Cys Val Pro Asn Gly Ser Ala Tyr Ser Gly Asp Tyr Met Glu 
            500                 505                 510         


Pro Glu Lys Pro Gly Ala Pro Leu Leu Pro Pro Pro Pro Gln Asn Ser 
        515                 520                 525             


Val Pro His Tyr Ala Glu Ala Asp Ile Val Thr Leu Gln Gly Val Thr 
    530                 535                 540                 


Gly Gly Asn Thr Tyr Ala Val Pro Ala Leu Pro Pro Gly Ala Val Gly 
545                 550                 555                 560 


Asp Gly Pro Pro Arg Val Asp Phe Pro Arg Ser Arg Leu Arg Phe Lys 
                565                 570                 575     


Glu Lys Leu Gly Glu Gly Gln Phe Gly Glu Val His Leu Cys Glu Val 
            580                 585                 590         


Asp Ser Pro Gln Asp Leu Val Ser Leu Asp Phe Pro Leu Asn Val Arg 
        595                 600                 605             


Lys Gly His Pro Leu Leu Val Ala Val Lys Ile Leu Arg Pro Asp Ala 
    610                 615                 620                 


Thr Lys Asn Ala Arg Asn Asp Phe Leu Lys Glu Val Lys Ile Met Ser 
625                 630                 635                 640 


Arg Leu Lys Asp Pro Asn Ile Ile Arg Leu Leu Gly Val Cys Val Gln 
                645                 650                 655     


Asp Asp Pro Leu Cys Met Ile Thr Asp Tyr Met Glu Asn Gly Asp Leu 
            660                 665                 670         


Asn Gln Phe Leu Ser Ala His Gln Leu Glu Asp Lys Ala Ala Glu Gly 
        675                 680                 685             


Ala Pro Gly Asp Gly Gln Ala Ala Gln Gly Pro Thr Ile Ser Tyr Pro 
    690                 695                 700                 


Met Leu Leu His Val Ala Ala Gln Ile Ala Ser Gly Met Arg Tyr Leu 
705                 710                 715                 720 


Ala Thr Leu Asn Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu 
                725                 730                 735     


Val Gly Glu Asn Phe Thr Ile Lys Ile Ala Asp Phe Gly Met Ser Arg 
            740                 745                 750         


Asn Leu Tyr Ala Gly Asp Tyr Tyr Arg Val Gln Gly Arg Ala Val Leu 
        755                 760                 765             


Pro Ile Arg Trp Met Ala Trp Glu Cys Ile Leu Met Gly Lys Phe Thr 
    770                 775                 780                 


Thr Ala Ser Asp Val Trp Ala Phe Gly Val Thr Leu Trp Glu Val Leu 
785                 790                 795                 800 


Met Leu Cys Arg Ala Gln Pro Phe Gly Gln Leu Thr Asp Glu Gln Val 
                805                 810                 815     


Ile Glu Asn Ala Gly Glu Phe Phe Arg Asp Gln Gly Arg Gln Val Tyr 
            820                 825                 830         


Leu Ser Arg Pro Pro Ala Cys Pro Gln Gly Leu Tyr Glu Leu Met Leu 
        835                 840                 845             


Arg Cys Trp Ser Arg Glu Ser Glu Gln Arg Pro Pro Phe Ser Gln Leu 
    850                 855                 860                 


His Arg Phe Leu Ala Glu Asp Ala Leu Asn Thr Val 
865                 870                 875     


<210>  4056
<211>  876
<212>  PRT
<213>  Homo Sapiens

<400>  4056

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg 
        115                 120                 125             


Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn 
    130                 135                 140                 


Glu Asp Pro Glu Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met Val 
145                 150                 155                 160 


Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Val Met Ser Val 
                165                 170                 175     


Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Gly Leu Leu 
            180                 185                 190         


Ser Tyr Thr Ala Pro Val Gly Gln Thr Met Tyr Leu Ser Glu Ala Val 
        195                 200                 205             


Tyr Leu Asn Asp Ser Thr Tyr Asp Gly His Thr Val Gly Gly Leu Gln 
    210                 215                 220                 


Tyr Gly Gly Leu Gly Gln Leu Ala Asp Gly Val Val Gly Leu Asp Asp 
225                 230                 235                 240 


Phe Arg Lys Ser Gln Glu Leu Arg Val Trp Pro Gly Tyr Asp Tyr Val 
                245                 250                 255     


Gly Trp Ser Asn His Ser Phe Ser Ser Gly Tyr Val Glu Met Glu Phe 
            260                 265                 270         


Glu Phe Asp Arg Leu Arg Ala Phe Gln Ala Met Gln Val His Cys Asn 
        275                 280                 285             


Asn Met His Thr Leu Gly Ala Arg Leu Pro Gly Gly Val Glu Cys Arg 
    290                 295                 300                 


Phe Arg Arg Gly Pro Ala Met Ala Trp Glu Gly Glu Pro Met Arg His 
305                 310                 315                 320 


Asn Leu Gly Gly Asn Leu Gly Asp Pro Arg Ala Arg Ala Val Ser Val 
                325                 330                 335     


Pro Leu Gly Gly Arg Val Ala Arg Phe Leu Gln Cys Arg Phe Leu Phe 
            340                 345                 350         


Ala Gly Pro Trp Leu Leu Phe Ser Glu Ile Ser Phe Ile Ser Asp Val 
        355                 360                 365             


Val Asn Asn Ser Ser Pro Ala Leu Gly Gly Thr Phe Pro Pro Ala Pro 
    370                 375                 380                 


Trp Trp Pro Pro Gly Pro Pro Pro Thr Asn Phe Ser Ser Leu Glu Leu 
385                 390                 395                 400 


Glu Pro Arg Gly Gln Gln Pro Val Ala Lys Ala Glu Gly Ser Pro Thr 
                405                 410                 415     


Ala Ile Leu Ile Gly Cys Leu Val Ala Ile Ile Leu Leu Leu Leu Leu 
            420                 425                 430         


Ile Ile Ala Leu Met Leu Trp Arg Leu His Trp Arg Arg Leu Leu Ser 
        435                 440                 445             


Lys Ala Glu Arg Arg Val Leu Glu Glu Glu Leu Thr Val His Leu Ser 
    450                 455                 460                 


Val Pro Gly Asp Thr Ile Leu Ile Asn Asn Arg Pro Gly Pro Arg Glu 
465                 470                 475                 480 


Pro Pro Pro Tyr Gln Glu Pro Arg Pro Arg Gly Asn Pro Pro His Ser 
                485                 490                 495     


Ala Pro Cys Val Pro Asn Gly Ser Ala Tyr Ser Gly Asp Tyr Met Glu 
            500                 505                 510         


Pro Glu Lys Pro Gly Ala Pro Leu Leu Pro Pro Pro Pro Gln Asn Ser 
        515                 520                 525             


Val Pro His Tyr Ala Glu Ala Asp Ile Val Thr Leu Gln Gly Val Thr 
    530                 535                 540                 


Gly Gly Asn Thr Tyr Ala Val Pro Ala Leu Pro Pro Gly Ala Val Gly 
545                 550                 555                 560 


Asp Gly Pro Pro Arg Val Asp Phe Pro Arg Ser Arg Leu Arg Phe Lys 
                565                 570                 575     


Glu Lys Leu Gly Glu Gly Gln Phe Gly Glu Val His Leu Cys Glu Val 
            580                 585                 590         


Asp Ser Pro Gln Asp Leu Val Ser Leu Asp Phe Pro Leu Asn Val Arg 
        595                 600                 605             


Lys Gly His Pro Leu Leu Val Ala Val Lys Ile Leu Arg Pro Asp Ala 
    610                 615                 620                 


Thr Lys Asn Ala Arg Asn Asp Phe Leu Lys Glu Val Lys Ile Met Ser 
625                 630                 635                 640 


Arg Leu Lys Asp Pro Asn Ile Ile Arg Leu Leu Gly Val Cys Val Gln 
                645                 650                 655     


Asp Asp Pro Leu Cys Met Ile Thr Asp Tyr Met Glu Asn Gly Asp Leu 
            660                 665                 670         


Asn Gln Phe Leu Ser Ala His Gln Leu Glu Asp Lys Ala Ala Glu Gly 
        675                 680                 685             


Ala Pro Gly Asp Gly Gln Ala Ala Gln Gly Pro Thr Ile Ser Tyr Pro 
    690                 695                 700                 


Met Leu Leu His Val Ala Ala Gln Ile Ala Ser Gly Met Arg Tyr Leu 
705                 710                 715                 720 


Ala Thr Leu Asn Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu 
                725                 730                 735     


Val Gly Glu Asn Phe Thr Ile Lys Ile Ala Asp Phe Gly Met Ser Arg 
            740                 745                 750         


Asn Leu Tyr Ala Gly Asp Tyr Tyr Arg Val Gln Gly Arg Ala Val Leu 
        755                 760                 765             


Pro Ile Arg Trp Met Ala Trp Glu Cys Ile Leu Met Gly Lys Phe Thr 
    770                 775                 780                 


Thr Ala Ser Asp Val Trp Ala Phe Gly Val Thr Leu Trp Glu Val Leu 
785                 790                 795                 800 


Met Leu Cys Arg Ala Gln Pro Phe Gly Gln Leu Thr Asp Glu Gln Val 
                805                 810                 815     


Ile Glu Asn Ala Gly Glu Phe Phe Arg Asp Gln Gly Arg Gln Val Tyr 
            820                 825                 830         


Leu Ser Arg Pro Pro Ala Cys Pro Gln Gly Leu Tyr Glu Leu Met Leu 
        835                 840                 845             


Arg Cys Trp Ser Arg Glu Ser Glu Gln Arg Pro Pro Phe Ser Gln Leu 
    850                 855                 860                 


His Arg Phe Leu Ala Glu Asp Ala Leu Asn Thr Val 
865                 870                 875     


<210>  4057
<211>  919
<212>  PRT
<213>  Homo Sapiens

<400>  4057

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg 
        115                 120                 125             


Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn 
    130                 135                 140                 


Glu Asp Pro Glu Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met Val 
145                 150                 155                 160 


Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Val Met Ser Val 
                165                 170                 175     


Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Gly Leu Leu 
            180                 185                 190         


Ser Tyr Thr Ala Pro Val Gly Gln Thr Met Tyr Leu Ser Glu Ala Val 
        195                 200                 205             


Tyr Leu Asn Asp Ser Thr Tyr Asp Gly His Thr Val Gly Gly Leu Gln 
    210                 215                 220                 


Tyr Gly Gly Leu Gly Gln Leu Ala Asp Gly Val Val Gly Leu Asp Asp 
225                 230                 235                 240 


Phe Arg Lys Ser Gln Glu Leu Arg Val Trp Pro Gly Tyr Asp Tyr Val 
                245                 250                 255     


Gly Trp Ser Asn His Ser Phe Ser Ser Gly Tyr Val Glu Met Glu Phe 
            260                 265                 270         


Glu Phe Asp Arg Leu Arg Ala Phe Gln Ala Met Gln Val His Cys Asn 
        275                 280                 285             


Asn Met His Thr Leu Gly Ala Arg Leu Pro Gly Gly Val Glu Cys Arg 
    290                 295                 300                 


Phe Arg Arg Gly Pro Ala Met Ala Trp Glu Gly Glu Pro Met Arg His 
305                 310                 315                 320 


Asn Leu Gly Gly Asn Leu Gly Asp Pro Arg Ala Arg Ala Val Ser Val 
                325                 330                 335     


Pro Leu Gly Gly Arg Val Ala Arg Phe Leu Gln Cys Arg Phe Leu Phe 
            340                 345                 350         


Ala Gly Pro Trp Leu Leu Phe Ser Glu Ile Ser Phe Ile Ser Asp Val 
        355                 360                 365             


Val Asn Asn Ser Ser Pro Ala Leu Gly Gly Thr Phe Pro Pro Ala Pro 
    370                 375                 380                 


Trp Trp Pro Pro Gly Pro Pro Pro Thr Asn Phe Ser Ser Leu Glu Leu 
385                 390                 395                 400 


Glu Pro Arg Gly Gln Gln Pro Val Ala Lys Ala Glu Gly Ser Pro Thr 
                405                 410                 415     


Ala Ile Leu Ile Gly Cys Leu Val Ala Ile Ile Leu Leu Leu Leu Leu 
            420                 425                 430         


Ile Ile Ala Leu Met Leu Trp Arg Leu His Trp Arg Arg Leu Leu Ser 
        435                 440                 445             


Lys Ala Glu Arg Arg Val Leu Glu Glu Glu Leu Thr Val His Leu Ser 
    450                 455                 460                 


Val Pro Gly Asp Thr Ile Leu Ile Asn Asn Arg Pro Gly Pro Arg Glu 
465                 470                 475                 480 


Pro Pro Pro Tyr Gln Glu Pro Arg Pro Arg Gly Asn Pro Pro His Ser 
                485                 490                 495     


Ala Pro Cys Val Pro Asn Gly Ser Ala Leu Leu Leu Ser Asn Pro Ala 
            500                 505                 510         


Tyr Arg Leu Leu Leu Ala Thr Tyr Ala Arg Pro Pro Arg Gly Pro Gly 
        515                 520                 525             


Pro Pro Thr Pro Ala Trp Ala Lys Pro Thr Asn Thr Gln Ala Tyr Ser 
    530                 535                 540                 


Gly Asp Tyr Met Glu Pro Glu Lys Pro Gly Ala Pro Leu Leu Pro Pro 
545                 550                 555                 560 


Pro Pro Gln Asn Ser Val Pro His Tyr Ala Glu Ala Asp Ile Val Thr 
                565                 570                 575     


Leu Gln Gly Val Thr Gly Gly Asn Thr Tyr Ala Val Pro Ala Leu Pro 
            580                 585                 590         


Pro Gly Ala Val Gly Asp Gly Pro Pro Arg Val Asp Phe Pro Arg Ser 
        595                 600                 605             


Arg Leu Arg Phe Lys Glu Lys Leu Gly Glu Gly Gln Phe Gly Glu Val 
    610                 615                 620                 


His Leu Cys Glu Val Asp Ser Pro Gln Asp Leu Val Ser Leu Asp Phe 
625                 630                 635                 640 


Pro Leu Asn Val Arg Lys Gly His Pro Leu Leu Val Ala Val Lys Ile 
                645                 650                 655     


Leu Arg Pro Asp Ala Thr Lys Asn Ala Ser Phe Ser Leu Phe Ser Arg 
            660                 665                 670         


Asn Asp Phe Leu Lys Glu Val Lys Ile Met Ser Arg Leu Lys Asp Pro 
        675                 680                 685             


Asn Ile Ile Arg Leu Leu Gly Val Cys Val Gln Asp Asp Pro Leu Cys 
    690                 695                 700                 


Met Ile Thr Asp Tyr Met Glu Asn Gly Asp Leu Asn Gln Phe Leu Ser 
705                 710                 715                 720 


Ala His Gln Leu Glu Asp Lys Ala Ala Glu Gly Ala Pro Gly Asp Gly 
                725                 730                 735     


Gln Ala Ala Gln Gly Pro Thr Ile Ser Tyr Pro Met Leu Leu His Val 
            740                 745                 750         


Ala Ala Gln Ile Ala Ser Gly Met Arg Tyr Leu Ala Thr Leu Asn Phe 
        755                 760                 765             


Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Glu Asn Phe 
    770                 775                 780                 


Thr Ile Lys Ile Ala Asp Phe Gly Met Ser Arg Asn Leu Tyr Ala Gly 
785                 790                 795                 800 


Asp Tyr Tyr Arg Val Gln Gly Arg Ala Val Leu Pro Ile Arg Trp Met 
                805                 810                 815     


Ala Trp Glu Cys Ile Leu Met Gly Lys Phe Thr Thr Ala Ser Asp Val 
            820                 825                 830         


Trp Ala Phe Gly Val Thr Leu Trp Glu Val Leu Met Leu Cys Arg Ala 
        835                 840                 845             


Gln Pro Phe Gly Gln Leu Thr Asp Glu Gln Val Ile Glu Asn Ala Gly 
    850                 855                 860                 


Glu Phe Phe Arg Asp Gln Gly Arg Gln Val Tyr Leu Ser Arg Pro Pro 
865                 870                 875                 880 


Ala Cys Pro Gln Gly Leu Tyr Glu Leu Met Leu Arg Cys Trp Ser Arg 
                885                 890                 895     


Glu Ser Glu Gln Arg Pro Pro Phe Ser Gln Leu His Arg Phe Leu Ala 
            900                 905                 910         


Glu Asp Ala Leu Asn Thr Val 
        915                 


<210>  4058
<211>  286
<212>  PRT
<213>  Homo Sapiens

<400>  4058

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg 
        115                 120                 125             


Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn 
    130                 135                 140                 


Glu Asp Pro Glu Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met Val 
145                 150                 155                 160 


Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Val Met Ser Val 
                165                 170                 175     


Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Gly Leu Leu 
            180                 185                 190         


Ser Tyr Thr Ala Pro Val Gly Gln Thr Met Tyr Leu Ser Glu Ala Val 
        195                 200                 205             


Tyr Leu Asn Asp Ser Thr Tyr Asp Gly His Thr Val Gly Gly Leu Gln 
    210                 215                 220                 


Tyr Gly Gly Leu Gly Gln Leu Ala Asp Gly Val Val Gly Leu Asp Asp 
225                 230                 235                 240 


Phe Arg Lys Ser Gln Glu Leu Arg Val Trp Pro Gly Tyr Asp Tyr Val 
                245                 250                 255     


Gly Trp Ser Asn His Ser Phe Ser Ser Gly Tyr Val Glu Met Glu Phe 
            260                 265                 270         


Glu Phe Asp Arg Leu Arg Ala Phe Gln Ala Met Gln Val His 
        275                 280                 285     


<210>  4059
<211>  913
<212>  PRT
<213>  Homo Sapiens

<400>  4059

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg 
        115                 120                 125             


Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn 
    130                 135                 140                 


Glu Asp Pro Glu Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met Val 
145                 150                 155                 160 


Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Val Met Ser Val 
                165                 170                 175     


Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Gly Leu Leu 
            180                 185                 190         


Ser Tyr Thr Ala Pro Val Gly Gln Thr Met Tyr Leu Ser Glu Ala Val 
        195                 200                 205             


Tyr Leu Asn Asp Ser Thr Tyr Asp Gly His Thr Val Gly Gly Leu Gln 
    210                 215                 220                 


Tyr Gly Gly Leu Gly Gln Leu Ala Asp Gly Val Val Gly Leu Asp Asp 
225                 230                 235                 240 


Phe Arg Lys Ser Gln Glu Leu Arg Val Trp Pro Gly Tyr Asp Tyr Val 
                245                 250                 255     


Gly Trp Ser Asn His Ser Phe Ser Ser Gly Tyr Val Glu Met Glu Phe 
            260                 265                 270         


Glu Phe Asp Arg Leu Arg Ala Phe Gln Ala Met Gln Val His Cys Asn 
        275                 280                 285             


Asn Met His Thr Leu Gly Ala Arg Leu Pro Gly Gly Val Glu Cys Arg 
    290                 295                 300                 


Phe Arg Arg Gly Pro Ala Met Ala Trp Glu Gly Glu Pro Met Arg His 
305                 310                 315                 320 


Asn Leu Gly Gly Asn Leu Gly Asp Pro Arg Ala Arg Ala Val Ser Val 
                325                 330                 335     


Pro Leu Gly Gly Arg Val Ala Arg Phe Leu Gln Cys Arg Phe Leu Phe 
            340                 345                 350         


Ala Gly Pro Trp Leu Leu Phe Ser Glu Ile Ser Phe Ile Ser Asp Val 
        355                 360                 365             


Val Asn Asn Ser Ser Pro Ala Leu Gly Gly Thr Phe Pro Pro Ala Pro 
    370                 375                 380                 


Trp Trp Pro Pro Gly Pro Pro Pro Thr Asn Phe Ser Ser Leu Glu Leu 
385                 390                 395                 400 


Glu Pro Arg Gly Gln Gln Pro Val Ala Lys Ala Glu Gly Ser Pro Thr 
                405                 410                 415     


Ala Ile Leu Ile Gly Cys Leu Val Ala Ile Ile Leu Leu Leu Leu Leu 
            420                 425                 430         


Ile Ile Ala Leu Met Leu Trp Arg Leu His Trp Arg Arg Leu Leu Ser 
        435                 440                 445             


Lys Ala Glu Arg Arg Val Leu Glu Glu Glu Leu Thr Val His Leu Ser 
    450                 455                 460                 


Val Pro Gly Asp Thr Ile Leu Ile Asn Asn Arg Pro Gly Pro Arg Glu 
465                 470                 475                 480 


Pro Pro Pro Tyr Gln Glu Pro Arg Pro Arg Gly Asn Pro Pro His Ser 
                485                 490                 495     


Ala Pro Cys Val Pro Asn Gly Ser Ala Leu Leu Leu Ser Asn Pro Ala 
            500                 505                 510         


Tyr Arg Leu Leu Leu Ala Thr Tyr Ala Arg Pro Pro Arg Gly Pro Gly 
        515                 520                 525             


Pro Pro Thr Pro Ala Trp Ala Lys Pro Thr Asn Thr Gln Ala Tyr Ser 
    530                 535                 540                 


Gly Asp Tyr Met Glu Pro Glu Lys Pro Gly Ala Pro Leu Leu Pro Pro 
545                 550                 555                 560 


Pro Pro Gln Asn Ser Val Pro His Tyr Ala Glu Ala Asp Ile Val Thr 
                565                 570                 575     


Leu Gln Gly Val Thr Gly Gly Asn Thr Tyr Ala Val Pro Ala Leu Pro 
            580                 585                 590         


Pro Gly Ala Val Gly Asp Gly Pro Pro Arg Val Asp Phe Pro Arg Ser 
        595                 600                 605             


Arg Leu Arg Phe Lys Glu Lys Leu Gly Glu Gly Gln Phe Gly Glu Val 
    610                 615                 620                 


His Leu Cys Glu Val Asp Ser Pro Gln Asp Leu Val Ser Leu Asp Phe 
625                 630                 635                 640 


Pro Leu Asn Val Arg Lys Gly His Pro Leu Leu Val Ala Val Lys Ile 
                645                 650                 655     


Leu Arg Pro Asp Ala Thr Lys Asn Ala Arg Asn Asp Phe Leu Lys Glu 
            660                 665                 670         


Val Lys Ile Met Ser Arg Leu Lys Asp Pro Asn Ile Ile Arg Leu Leu 
        675                 680                 685             


Gly Val Cys Val Gln Asp Asp Pro Leu Cys Met Ile Thr Asp Tyr Met 
    690                 695                 700                 


Glu Asn Gly Asp Leu Asn Gln Phe Leu Ser Ala His Gln Leu Glu Asp 
705                 710                 715                 720 


Lys Ala Ala Glu Gly Ala Pro Gly Asp Gly Gln Ala Ala Gln Gly Pro 
                725                 730                 735     


Thr Ile Ser Tyr Pro Met Leu Leu His Val Ala Ala Gln Ile Ala Ser 
            740                 745                 750         


Gly Met Arg Tyr Leu Ala Thr Leu Asn Phe Val His Arg Asp Leu Ala 
        755                 760                 765             


Thr Arg Asn Cys Leu Val Gly Glu Asn Phe Thr Ile Lys Ile Ala Asp 
    770                 775                 780                 


Phe Gly Met Ser Arg Asn Leu Tyr Ala Gly Asp Tyr Tyr Arg Val Gln 
785                 790                 795                 800 


Gly Arg Ala Val Leu Pro Ile Arg Trp Met Ala Trp Glu Cys Ile Leu 
                805                 810                 815     


Met Gly Lys Phe Thr Thr Ala Ser Asp Val Trp Ala Phe Gly Val Thr 
            820                 825                 830         


Leu Trp Glu Val Leu Met Leu Cys Arg Ala Gln Pro Phe Gly Gln Leu 
        835                 840                 845             


Thr Asp Glu Gln Val Ile Glu Asn Ala Gly Glu Phe Phe Arg Asp Gln 
    850                 855                 860                 


Gly Arg Gln Val Tyr Leu Ser Arg Pro Pro Ala Cys Pro Gln Gly Leu 
865                 870                 875                 880 


Tyr Glu Leu Met Leu Arg Cys Trp Ser Arg Glu Ser Glu Gln Arg Pro 
                885                 890                 895     


Pro Phe Ser Gln Leu His Arg Phe Leu Ala Glu Asp Ala Leu Asn Thr 
            900                 905                 910         


Val 
    


<210>  4060
<211>  35
<212>  PRT
<213>  Homo Sapiens

<400>  4060

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Gly Pro Asp His 
            20                  25                  30          


Pro Arg Gln 
        35  


<210>  4061
<211>  35
<212>  PRT
<213>  Homo Sapiens

<400>  4061

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Gly Pro Asp His 
            20                  25                  30          


Pro Arg Gln 
        35  


<210>  4062
<211>  196
<212>  PRT
<213>  Homo Sapiens

<400>  4062

Met Pro His Leu Ala Ser Leu Phe Thr Ala Ser Ser Arg Cys Cys Pro 
1               5                   10                  15      


His Pro Leu Arg Pro Glu Gly Ser Gly Ala Met Gly Pro Glu Ala Leu 
            20                  25                  30          


Ser Ser Leu Leu Leu Leu Leu Leu Val Ala Ser Gly Asp Ala Asp Met 
        35                  40                  45              


Lys Gly His Phe Asp Pro Ala Lys Cys Arg Tyr Ala Leu Gly Met Gln 
    50                  55                  60                  


Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser Ala Ser Ser Ser Trp Ser 
65                  70                  75                  80  


Asp Ser Thr Ala Ala Arg His Ser Arg Leu Glu Ser Ser Asp Gly Asp 
                85                  90                  95      


Gly Ala Trp Cys Pro Ala Gly Ser Val Phe Pro Lys Glu Glu Glu Tyr 
            100                 105                 110         


Leu Gln Val Asp Leu Gln Arg Leu His Leu Val Ala Leu Val Gly Thr 
        115                 120                 125             


Gln Gly Arg His Ala Gly Gly Leu Gly Lys Glu Phe Ser Arg Ser Tyr 
    130                 135                 140                 


Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg Trp Met Gly Trp Lys Asp 
145                 150                 155                 160 


Arg Trp Gly Gln Glu Val Ile Ser Gly Asn Glu Asp Pro Glu Gly Val 
                165                 170                 175     


Val Leu Lys Asp Leu Gly Pro Pro Met Val Ala Arg Leu Val Arg Phe 
            180                 185                 190         


Tyr Pro Arg Ala 
        195     


<210>  4063
<211>  894
<212>  PRT
<213>  Homo Sapiens

<400>  4063

Met Ser Leu Pro Arg Cys Cys Pro His Pro Leu Arg Pro Glu Gly Ser 
1               5                   10                  15      


Gly Ala Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu 
            20                  25                  30          


Val Ala Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys 
        35                  40                  45              


Cys Arg Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp 
    50                  55                  60                  


Ile Ser Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser 
65                  70                  75                  80  


Arg Leu Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser 
                85                  90                  95      


Val Phe Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu 
            100                 105                 110         


His Leu Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu 
        115                 120                 125             


Gly Lys Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly 
    130                 135                 140                 


Arg Arg Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser 
145                 150                 155                 160 


Gly Asn Glu Asp Pro Glu Gly Val Val Leu Lys Asp Leu Gly Pro Pro 
                165                 170                 175     


Met Val Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Val Met 
            180                 185                 190         


Ser Val Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Gly 
        195                 200                 205             


Leu Leu Ser Tyr Thr Ala Pro Val Gly Gln Thr Met Tyr Leu Ser Glu 
    210                 215                 220                 


Ala Val Tyr Leu Asn Asp Ser Thr Tyr Asp Gly His Thr Val Gly Gly 
225                 230                 235                 240 


Leu Gln Tyr Gly Gly Leu Gly Gln Leu Ala Asp Gly Val Val Gly Leu 
                245                 250                 255     


Asp Asp Phe Arg Lys Ser Gln Glu Leu Arg Val Trp Pro Gly Tyr Asp 
            260                 265                 270         


Tyr Val Gly Trp Ser Asn His Ser Phe Ser Ser Gly Tyr Val Glu Met 
        275                 280                 285             


Glu Phe Glu Phe Asp Arg Leu Arg Ala Phe Gln Ala Met Gln Val His 
    290                 295                 300                 


Cys Asn Asn Met His Thr Leu Gly Ala Arg Leu Pro Gly Gly Val Glu 
305                 310                 315                 320 


Cys Arg Phe Arg Arg Gly Pro Ala Met Ala Trp Glu Gly Glu Pro Met 
                325                 330                 335     


Arg His Asn Leu Gly Gly Asn Leu Gly Asp Pro Arg Ala Arg Ala Val 
            340                 345                 350         


Ser Val Pro Leu Gly Gly Arg Val Ala Arg Phe Leu Gln Cys Arg Phe 
        355                 360                 365             


Leu Phe Ala Gly Pro Trp Leu Leu Phe Ser Glu Ile Ser Phe Ile Ser 
    370                 375                 380                 


Asp Val Val Asn Asn Ser Ser Pro Ala Leu Gly Gly Thr Phe Pro Pro 
385                 390                 395                 400 


Ala Pro Trp Trp Pro Pro Gly Pro Pro Pro Thr Asn Phe Ser Ser Leu 
                405                 410                 415     


Glu Leu Glu Pro Arg Gly Gln Gln Pro Val Ala Lys Ala Glu Gly Ser 
            420                 425                 430         


Pro Thr Ala Ile Leu Ile Gly Cys Leu Val Ala Ile Ile Leu Leu Leu 
        435                 440                 445             


Leu Leu Ile Ile Ala Leu Met Leu Trp Arg Leu His Trp Arg Arg Leu 
    450                 455                 460                 


Leu Ser Lys Ala Glu Arg Arg Val Leu Glu Glu Glu Leu Thr Val His 
465                 470                 475                 480 


Leu Ser Val Pro Gly Asp Thr Ile Leu Ile Asn Asn Arg Pro Gly Pro 
                485                 490                 495     


Arg Glu Pro Pro Pro Tyr Gln Glu Pro Arg Pro Arg Gly Asn Pro Pro 
            500                 505                 510         


His Ser Ala Pro Cys Val Pro Asn Gly Ser Ala Tyr Ser Gly Asp Tyr 
        515                 520                 525             


Met Glu Pro Glu Lys Pro Gly Ala Pro Leu Leu Pro Pro Pro Pro Gln 
    530                 535                 540                 


Asn Ser Val Pro His Tyr Ala Glu Ala Asp Ile Val Thr Leu Gln Gly 
545                 550                 555                 560 


Val Thr Gly Gly Asn Thr Tyr Ala Val Pro Ala Leu Pro Pro Gly Ala 
                565                 570                 575     


Val Gly Asp Gly Pro Pro Arg Val Asp Phe Pro Arg Ser Arg Leu Arg 
            580                 585                 590         


Phe Lys Glu Lys Leu Gly Glu Gly Gln Phe Gly Glu Val His Leu Cys 
        595                 600                 605             


Glu Val Asp Ser Pro Gln Asp Leu Val Ser Leu Asp Phe Pro Leu Asn 
    610                 615                 620                 


Val Arg Lys Gly His Pro Leu Leu Val Ala Val Lys Ile Leu Arg Pro 
625                 630                 635                 640 


Asp Ala Thr Lys Asn Ala Arg Asn Asp Phe Leu Lys Glu Val Lys Ile 
                645                 650                 655     


Met Ser Arg Leu Lys Asp Pro Asn Ile Ile Arg Leu Leu Gly Val Cys 
            660                 665                 670         


Val Gln Asp Asp Pro Leu Cys Met Ile Thr Asp Tyr Met Glu Asn Gly 
        675                 680                 685             


Asp Leu Asn Gln Phe Leu Ser Ala His Gln Leu Glu Asp Lys Ala Ala 
    690                 695                 700                 


Glu Gly Ala Pro Gly Asp Gly Gln Ala Ala Gln Gly Pro Thr Ile Ser 
705                 710                 715                 720 


Tyr Pro Met Leu Leu His Val Ala Ala Gln Ile Ala Ser Gly Met Arg 
                725                 730                 735     


Tyr Leu Ala Thr Leu Asn Phe Val His Arg Asp Leu Ala Thr Arg Asn 
            740                 745                 750         


Cys Leu Val Gly Glu Asn Phe Thr Ile Lys Ile Ala Asp Phe Gly Met 
        755                 760                 765             


Ser Arg Asn Leu Tyr Ala Gly Asp Tyr Tyr Arg Val Gln Gly Arg Ala 
    770                 775                 780                 


Val Leu Pro Ile Arg Trp Met Ala Trp Glu Cys Ile Leu Met Gly Lys 
785                 790                 795                 800 


Phe Thr Thr Ala Ser Asp Val Trp Ala Phe Gly Val Thr Leu Trp Glu 
                805                 810                 815     


Val Leu Met Leu Cys Arg Ala Gln Pro Phe Gly Gln Leu Thr Asp Glu 
            820                 825                 830         


Gln Val Ile Glu Asn Ala Gly Glu Phe Phe Arg Asp Gln Gly Arg Gln 
        835                 840                 845             


Val Tyr Leu Ser Arg Pro Pro Ala Cys Pro Gln Gly Leu Tyr Glu Leu 
    850                 855                 860                 


Met Leu Arg Cys Trp Ser Arg Glu Ser Glu Gln Arg Pro Pro Phe Ser 
865                 870                 875                 880 


Gln Leu His Arg Phe Leu Ala Glu Asp Ala Leu Asn Thr Val 
                885                 890                 


<210>  4064
<211>  69
<212>  PRT
<213>  Homo Sapiens

<400>  4064

Met Val Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Val Met 
1               5                   10                  15      


Ser Val Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Gly 
            20                  25                  30          


Leu Leu Ser Tyr Thr Ala Pro Val Gly Gln Thr Met Tyr Leu Ser Glu 
        35                  40                  45              


Ala Val Tyr Leu Asn Asp Ser Thr Tyr Asp Gly His Thr Val Gly Gly 
    50                  55                  60                  


Leu Gln Tyr Gly Gly 
65                  


<210>  4065
<211>  493
<212>  PRT
<213>  Homo Sapiens

<400>  4065

Ser Glu Ala Val Tyr Leu Asn Asp Ser Thr Tyr Asp Gly His Thr Val 
1               5                   10                  15      


Gly Gly Leu Gln Tyr Gly Gly Leu Gly Gln Leu Ala Asp Gly Val Val 
            20                  25                  30          


Gly Leu Asp Asp Phe Arg Lys Ser Gln Glu Leu Arg Val Trp Pro Gly 
        35                  40                  45              


Tyr Asp Tyr Val Gly Trp Ser Asn His Ser Phe Ser Ser Gly Tyr Val 
    50                  55                  60                  


Glu Met Glu Phe Glu Phe Asp Arg Leu Arg Ala Phe Gln Ala Met Gln 
65                  70                  75                  80  


Val His Cys Asn Asn Met His Thr Leu Gly Ala Arg Leu Pro Gly Gly 
                85                  90                  95      


Val Glu Cys Arg Phe Arg Arg Gly Pro Ala Met Ala Trp Glu Gly Glu 
            100                 105                 110         


Pro Met Arg His Asn Leu Gly Gly Asn Leu Gly Asp Pro Arg Ala Arg 
        115                 120                 125             


Ala Val Ser Val Pro Leu Gly Gly Arg Val Ala Arg Phe Leu Gln Cys 
    130                 135                 140                 


Arg Phe Leu Phe Ala Gly Pro Trp Leu Leu Phe Ser Glu Ile Ser Phe 
145                 150                 155                 160 


Ile Ser Asp Val Val Asn Asn Ser Ser Pro Ala Leu Gly Gly Thr Phe 
                165                 170                 175     


Pro Pro Ala Pro Trp Trp Pro Pro Gly Pro Pro Pro Thr Asn Phe Ser 
            180                 185                 190         


Ser Leu Glu Leu Glu Pro Arg Gly Gln Gln Pro Val Ala Lys Ala Glu 
        195                 200                 205             


Gly Ser Pro Thr Ala Ile Leu Ile Gly Cys Leu Val Ala Ile Ile Leu 
    210                 215                 220                 


Leu Leu Leu Leu Ile Ile Ala Leu Met Leu Trp Arg Leu His Trp Arg 
225                 230                 235                 240 


Arg Leu Leu Ser Lys Val Leu Glu Ser His Pro Arg Thr Arg Ser Pro 
                245                 250                 255     


Gly Leu Val Gly Ile Arg Pro Thr Pro Leu Pro Val Ser Pro Met Ala 
            260                 265                 270         


Leu Arg Cys Cys Ser Pro Ile Gln Pro Thr Ala Ser Phe Trp Pro Leu 
        275                 280                 285             


Thr Pro Val Pro Leu Glu Ala Arg Ala Pro Pro His Pro Pro Gly Pro 
    290                 295                 300                 


Asn Pro Pro Thr Pro Arg Gly Val Thr Gly Gly Asn Thr Tyr Ala Val 
305                 310                 315                 320 


Pro Ala Leu Pro Pro Gly Ala Val Gly Asp Gly Pro Pro Arg Val Asp 
                325                 330                 335     


Phe Pro Arg Ser Arg Leu Arg Phe Lys Glu Lys Leu Gly Glu Gly Gln 
            340                 345                 350         


Phe Gly Glu Val His Leu Cys Glu Val Asp Ser Pro Gln Asp Leu Val 
        355                 360                 365             


Ser Leu Asp Phe Pro Leu Asn Val Arg Lys Gly His Pro Leu Leu Val 
    370                 375                 380                 


Ala Val Lys Ile Leu Arg Pro Asp Ala Thr Lys Asn Ala Arg Asn Asp 
385                 390                 395                 400 


Phe Leu Lys Glu Val Lys Ile Met Ser Arg Leu Lys Asp Pro Asn Ile 
                405                 410                 415     


Ile Arg Leu Leu Gly Val Cys Val Gln Asp Asp Pro Leu Cys Met Ile 
            420                 425                 430         


Thr Asp Tyr Met Glu Asn Gly Asp Leu Asn Gln Phe Leu Ser Ala His 
        435                 440                 445             


Gln Leu Glu Asp Lys Ala Ala Glu Gly Ala Pro Gly Asp Gly Gln Ala 
    450                 455                 460                 


Ala Gln Gly Pro Thr Ile Ser Tyr Pro Met Leu Leu His Val Ala Ala 
465                 470                 475                 480 


Gln Ile Ala Ser Gly Met Arg Tyr Leu Ala Thr Leu Asn 
                485                 490             


<210>  4066
<211>  172
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4066

Xaa Asn Asn Arg Pro Gly Pro Arg Glu Pro Pro Pro Tyr Gln Glu Pro 
1               5                   10                  15      


Arg Pro Arg Gly Asn Pro Pro His Ser Ala Pro Cys Val Pro Asn Gly 
            20                  25                  30          


Ser Ala Tyr Ser Gly Asp Tyr Met Glu Pro Glu Lys Pro Gly Ala Pro 
        35                  40                  45              


Leu Leu Pro Pro Pro Pro Gln Asn Ser Val Pro His Tyr Ala Glu Ala 
    50                  55                  60                  


Asp Ile Val Thr Leu Gln Gly Val Thr Gly Gly Asn Thr Tyr Ala Val 
65                  70                  75                  80  


Pro Ala Leu Pro Pro Gly Ala Val Gly Asp Gly Pro Pro Arg Val Asp 
                85                  90                  95      


Phe Pro Arg Ser Arg Leu Arg Phe Lys Glu Lys Leu Gly Glu Gly Gln 
            100                 105                 110         


Phe Gly Glu Val His Leu Cys Glu Val Asp Ser Pro Gln Asp Leu Val 
        115                 120                 125             


Ser Leu Asp Phe Pro Leu Asn Val Arg Lys Gly His Pro Leu Leu Val 
    130                 135                 140                 


Ala Val Lys Ile Leu Arg Pro Asp Ala Thr Lys Asn Ala Ser Phe Ser 
145                 150                 155                 160 


Leu Phe Ser Arg Asn Asp Phe Leu Lys Glu Val Lys 
                165                 170         


<210>  4067
<211>  277
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4067

Xaa Arg Lys Gly His Pro Leu Leu Val Ala Val Lys Ile Leu Arg Pro 
1               5                   10                  15      


Asp Ala Thr Lys Asn Ala Arg Asn Asp Phe Leu Lys Glu Val Lys Ile 
            20                  25                  30          


Met Ser Arg Leu Lys Asp Pro Asn Ile Ile Arg Leu Leu Gly Val Cys 
        35                  40                  45              


Val Gln Asp Asp Pro Leu Cys Met Ile Thr Asp Tyr Met Glu Asn Gly 
    50                  55                  60                  


Asp Leu Asn Gln Phe Leu Ser Ala His Gln Leu Glu Asp Lys Ala Ala 
65                  70                  75                  80  


Glu Gly Ala Pro Gly Asp Gly Gln Ala Ala Gln Gly Pro Thr Ile Ser 
                85                  90                  95      


Tyr Pro Met Leu Leu His Val Ala Ala Gln Ile Ala Ser Gly Met Arg 
            100                 105                 110         


Tyr Leu Ala Thr Leu Asn Phe Val His Arg Asp Leu Ala Thr Arg Asn 
        115                 120                 125             


Cys Leu Val Gly Glu Asn Phe Thr Ile Lys Ile Ala Asp Phe Gly Met 
    130                 135                 140                 


Ser Arg Asn Leu Tyr Ala Gly Asp Tyr Tyr Arg Val Gln Gly Arg Ala 
145                 150                 155                 160 


Val Leu Pro Ile Arg Trp Met Ala Trp Glu Cys Ile Leu Met Gly Lys 
                165                 170                 175     


Phe Thr Thr Ala Ser Asp Val Trp Ala Phe Gly Val Thr Leu Trp Glu 
            180                 185                 190         


Val Leu Met Leu Cys Arg Ala Gln Pro Phe Gly Gln Leu Thr Asp Glu 
        195                 200                 205             


Gln Val Ile Glu Asn Ala Gly Glu Phe Phe Arg Asp Gln Gly Arg Gln 
    210                 215                 220                 


Val Arg Val Glu Glu Arg Glu Asp Gly Ser Glu Ala Gly Asp Arg Arg 
225                 230                 235                 240 


Gly Arg Val Val Ile Leu Glu Thr Lys Glu Tyr Leu Phe Pro Asp Ser 
                245                 250                 255     


His Pro His Cys His Asn Ala Gly Val Pro Val Pro Ala Ala Cys Leu 
            260                 265                 270         


Pro Ala Gly Pro Ile 
        275         


<210>  4068
<211>  196
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4068

Xaa Ser Leu Leu Leu Leu Leu Leu Val Ala Ser Gly Asp Ala Asp Met 
1               5                   10                  15      


Lys Gly His Phe Asp Pro Ala Lys Cys Arg Tyr Ala Leu Gly Met Gln 
            20                  25                  30          


Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser Ala Ser Ser Ser Trp Leu 
        35                  40                  45              


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
    50                  55                  60                  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
65                  70                  75                  80  


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
                85                  90                  95      


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg 
            100                 105                 110         


Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn 
        115                 120                 125             


Glu Asp Pro Glu Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met Val 
    130                 135                 140                 


Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Val Met Ser Val 
145                 150                 155                 160 


Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Gly Leu Leu 
                165                 170                 175     


Ser Tyr Thr Ala Pro Val Gly Gln Thr Met Tyr Leu Ser Glu Ala Val 
            180                 185                 190         


Tyr Leu Asn Asp 
        195     


<210>  4069
<211>  166
<212>  PRT
<213>  Homo Sapiens

<400>  4069

Leu Lys Val Asp Asp Ser Asn Thr Arg Ile Leu Ile Gly Cys Leu Val 
1               5                   10                  15      


Ala Ile Ile Phe Ile Leu Leu Ala Ile Ile Val Ile Ile Leu Trp Arg 
            20                  25                  30          


Gln Phe Trp Gln Lys Met Leu Glu Lys Ala Ser Arg Arg Met Leu Asp 
        35                  40                  45              


Asp Glu Met Thr Val Ser Leu Ser Leu Pro Ser Asp Ser Ser Met Phe 
    50                  55                  60                  


Asn Asn Asn Arg Ser Ser Ser Pro Ser Glu Gln Gly Ser Asn Ser Thr 
65                  70                  75                  80  


Tyr Asp Arg Ile Phe Pro Leu Arg Pro Asp Tyr Gln Glu Pro Ser Arg 
                85                  90                  95      


Leu Ile Arg Lys Leu Pro Glu Phe Ala Pro Gly Glu Glu Glu Ser Gly 
            100                 105                 110         


Glu Asp Asp Val Val Gly Arg Val Ser Arg Glu Lys Pro Gln Gln Ala 
        115                 120                 125             


Ser Gly Arg Tyr Asp Thr Pro Ala Pro Ser Ser Leu His Leu Phe Leu 
    130                 135                 140                 


Val Ser Ala Asn Leu Leu Arg Ser Pro His Ser Leu Ser Arg Phe Gly 
145                 150                 155                 160 


Leu Pro Leu Leu Leu Ala 
                165     


<210>  4070
<211>  130
<212>  PRT
<213>  Homo Sapiens

<400>  4070

Met Ile Leu Ile Pro Arg Met Leu Leu Val Leu Phe Leu Leu Leu Pro 
1               5                   10                  15      


Ile Leu Ser Ser Ala Lys Ala Gln Val Asn Pro Ala Ile Cys Arg Tyr 
            20                  25                  30          


Pro Leu Gly Met Ser Gly Gly Gln Ile Pro Asp Glu Asp Ile Thr Ala 
        35                  40                  45              


Ser Ser Gln Trp Ser Glu Ser Thr Ala Ala Lys Tyr Gly Arg Leu Asp 
    50                  55                  60                  


Ser Glu Glu Gly Asp Gly Ala Trp Cys Pro Glu Ile Pro Val Glu Pro 
65                  70                  75                  80  


Asp Asp Leu Lys Glu Phe Leu Gln Ile Asp Leu His Thr Leu His Phe 
                85                  90                  95      


Ile Thr Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly His Gly Ile 
            100                 105                 110         


Glu Phe Ala Pro Met Tyr Lys Ile Asn Tyr Ser Arg Asp Gly Thr Arg 
        115                 120                 125             


Trp Ile 
    130 


<210>  4071
<211>  148
<212>  PRT
<213>  Homo Sapiens

<400>  4071

Met Ile Leu Ile Pro Arg Met Leu Leu Val Leu Phe Leu Leu Leu Pro 
1               5                   10                  15      


Ile Leu Ser Ser Ala Lys Ala Gln Val Asn Pro Ala Ile Cys Arg Tyr 
            20                  25                  30          


Pro Leu Gly Met Ser Gly Gly Gln Ile Pro Asp Glu Asp Ile Thr Ala 
        35                  40                  45              


Ser Ser Gln Trp Ser Glu Ser Thr Ala Ala Lys Tyr Gly Arg Leu Asp 
    50                  55                  60                  


Ser Glu Glu Gly Asp Gly Ala Trp Cys Pro Glu Ile Pro Val Glu Pro 
65                  70                  75                  80  


Asp Asp Leu Lys Glu Phe Leu Gln Ile Asp Leu His Thr Leu His Phe 
                85                  90                  95      


Ile Thr Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly His Gly Ile 
            100                 105                 110         


Glu Phe Ala Pro Met Tyr Lys Ile Asn Tyr Ser Arg Asp Gly Thr Arg 
        115                 120                 125             


Trp Ile Ser Trp Arg Asn Arg His Gly Lys Gln Val Leu Asp Gly Asn 
    130                 135                 140                 


Ser Asn Pro Tyr 
145             


<210>  4072
<211>  855
<212>  PRT
<213>  Homo Sapiens

<400>  4072

Met Ile Leu Ile Pro Arg Met Leu Leu Val Leu Phe Leu Leu Leu Pro 
1               5                   10                  15      


Ile Leu Ser Ser Ala Lys Ala Gln Val Asn Pro Ala Ile Cys Arg Tyr 
            20                  25                  30          


Pro Leu Gly Met Ser Gly Gly Gln Ile Pro Asp Glu Asp Ile Thr Ala 
        35                  40                  45              


Ser Ser Gln Trp Ser Glu Ser Thr Ala Ala Lys Tyr Gly Arg Leu Asp 
    50                  55                  60                  


Ser Glu Glu Gly Asp Gly Ala Trp Cys Pro Glu Ile Pro Val Glu Pro 
65                  70                  75                  80  


Asp Asp Leu Lys Glu Phe Leu Gln Ile Asp Leu His Thr Leu His Phe 
                85                  90                  95      


Ile Thr Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly His Gly Ile 
            100                 105                 110         


Glu Phe Ala Pro Met Tyr Lys Ile Asn Tyr Ser Arg Asp Gly Thr Arg 
        115                 120                 125             


Trp Ile Ser Trp Arg Asn Arg His Gly Lys Gln Val Leu Asp Gly Asn 
    130                 135                 140                 


Ser Asn Pro Tyr Asp Ile Phe Leu Lys Asp Leu Glu Pro Pro Ile Val 
145                 150                 155                 160 


Ala Arg Phe Val Arg Phe Ile Pro Val Thr Asp His Ser Met Asn Val 
                165                 170                 175     


Cys Met Arg Val Glu Leu Tyr Gly Cys Val Trp Leu Asp Gly Leu Val 
            180                 185                 190         


Ser Tyr Asn Ala Pro Ala Gly Gln Gln Phe Val Leu Pro Gly Gly Ser 
        195                 200                 205             


Ile Ile Tyr Leu Asn Asp Ser Val Tyr Asp Gly Ala Val Gly Tyr Ser 
    210                 215                 220                 


Met Thr Glu Gly Leu Gly Gln Leu Thr Asp Gly Val Ser Gly Leu Asp 
225                 230                 235                 240 


Asp Phe Thr Gln Thr His Glu Tyr His Val Trp Pro Gly Tyr Asp Tyr 
                245                 250                 255     


Val Gly Trp Arg Asn Glu Ser Ala Thr Asn Gly Tyr Ile Glu Ile Met 
            260                 265                 270         


Phe Glu Phe Asp Arg Ile Arg Asn Phe Thr Thr Met Lys Val His Cys 
        275                 280                 285             


Asn Asn Met Phe Ala Lys Gly Val Lys Ile Phe Lys Glu Val Gln Cys 
    290                 295                 300                 


Tyr Phe Arg Ser Glu Ala Ser Glu Trp Glu Pro Asn Ala Ile Ser Phe 
305                 310                 315                 320 


Pro Leu Val Leu Asp Asp Val Asn Pro Ser Ala Arg Phe Val Thr Val 
                325                 330                 335     


Pro Leu His His Arg Met Ala Ser Ala Ile Lys Cys Gln Tyr His Phe 
            340                 345                 350         


Ala Asp Thr Trp Met Met Phe Ser Glu Ile Thr Phe Gln Ser Asp Ala 
        355                 360                 365             


Ala Met Tyr Asn Asn Ser Glu Ala Leu Pro Thr Ser Pro Met Ala Pro 
    370                 375                 380                 


Thr Thr Tyr Asp Pro Met Leu Lys Val Asp Asp Ser Asn Thr Arg Ile 
385                 390                 395                 400 


Leu Ile Gly Cys Leu Val Ala Ile Ile Phe Ile Leu Leu Ala Ile Ile 
                405                 410                 415     


Val Ile Ile Leu Trp Arg Gln Phe Trp Gln Lys Met Leu Glu Lys Ala 
            420                 425                 430         


Ser Arg Arg Met Leu Asp Asp Glu Met Thr Val Ser Leu Ser Leu Pro 
        435                 440                 445             


Ser Asp Ser Ser Met Phe Asn Asn Asn Arg Ser Ser Ser Pro Ser Glu 
    450                 455                 460                 


Gln Gly Ser Asn Ser Thr Tyr Asp Arg Ile Phe Pro Leu Arg Pro Asp 
465                 470                 475                 480 


Tyr Gln Glu Pro Ser Arg Leu Ile Arg Lys Leu Pro Glu Phe Ala Pro 
                485                 490                 495     


Gly Glu Glu Glu Ser Gly Cys Ser Gly Val Val Lys Pro Val Gln Pro 
            500                 505                 510         


Ser Gly Pro Glu Gly Val Pro His Tyr Ala Glu Ala Asp Ile Val Asn 
        515                 520                 525             


Leu Gln Gly Val Thr Gly Gly Asn Thr Tyr Ser Val Pro Ala Val Thr 
    530                 535                 540                 


Met Asp Leu Leu Ser Gly Lys Asp Val Ala Val Glu Glu Phe Pro Arg 
545                 550                 555                 560 


Lys Leu Leu Thr Phe Lys Glu Lys Leu Gly Glu Gly Gln Phe Gly Glu 
                565                 570                 575     


Val His Leu Cys Glu Val Glu Gly Met Glu Lys Phe Lys Asp Lys Asp 
            580                 585                 590         


Phe Ala Leu Asp Val Ser Ala Asn Gln Pro Val Leu Val Ala Val Lys 
        595                 600                 605             


Met Leu Arg Ala Asp Ala Asn Lys Asn Ala Arg Asn Asp Phe Leu Lys 
    610                 615                 620                 


Glu Ile Lys Ile Met Ser Arg Leu Lys Asp Pro Asn Ile Ile His Leu 
625                 630                 635                 640 


Leu Ala Val Cys Ile Thr Asp Asp Pro Leu Cys Met Ile Thr Glu Tyr 
                645                 650                 655     


Met Glu Asn Gly Asp Leu Asn Gln Phe Leu Ser Arg His Glu Pro Pro 
            660                 665                 670         


Asn Ser Ser Ser Ser Asp Val Arg Thr Val Ser Tyr Thr Asn Leu Lys 
        675                 680                 685             


Phe Met Ala Thr Gln Ile Ala Ser Gly Met Lys Tyr Leu Ser Ser Leu 
    690                 695                 700                 


Asn Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Lys 
705                 710                 715                 720 


Asn Tyr Thr Ile Lys Ile Ala Asp Phe Gly Met Ser Arg Asn Leu Tyr 
                725                 730                 735     


Ser Gly Asp Tyr Tyr Arg Ile Gln Gly Arg Ala Val Leu Pro Ile Arg 
            740                 745                 750         


Trp Met Ser Trp Glu Ser Ile Leu Leu Gly Lys Phe Thr Thr Ala Ser 
        755                 760                 765             


Asp Val Trp Ala Phe Gly Val Thr Leu Trp Glu Thr Phe Thr Phe Cys 
    770                 775                 780                 


Gln Glu Gln Pro Tyr Ser Gln Leu Ser Asp Glu Gln Val Ile Glu Asn 
785                 790                 795                 800 


Thr Gly Glu Phe Phe Arg Asp Gln Gly Arg Gln Thr Tyr Leu Pro Gln 
                805                 810                 815     


Pro Ala Ile Cys Pro Asp Ser Val Tyr Lys Leu Met Leu Ser Cys Trp 
            820                 825                 830         


Arg Arg Asp Thr Lys Asn Arg Pro Ser Phe Gln Glu Ile His Leu Leu 
        835                 840                 845             


Leu Leu Gln Gln Gly Asp Glu 
    850                 855 


<210>  4073
<211>  855
<212>  PRT
<213>  Homo Sapiens

<400>  4073

Met Ile Leu Ile Pro Arg Met Leu Leu Val Leu Phe Leu Leu Leu Pro 
1               5                   10                  15      


Ile Leu Ser Ser Ala Lys Ala Gln Val Asn Pro Ala Ile Cys Arg Tyr 
            20                  25                  30          


Pro Leu Gly Met Ser Gly Gly Gln Ile Pro Asp Glu Asp Ile Thr Ala 
        35                  40                  45              


Ser Ser Gln Trp Ser Glu Ser Thr Ala Ala Lys Tyr Gly Arg Leu Asp 
    50                  55                  60                  


Ser Glu Glu Gly Asp Gly Ala Trp Cys Pro Glu Ile Pro Val Glu Pro 
65                  70                  75                  80  


Asp Asp Leu Lys Glu Phe Leu Gln Ile Asp Leu His Thr Leu His Phe 
                85                  90                  95      


Ile Thr Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly His Gly Ile 
            100                 105                 110         


Glu Phe Ala Pro Met Tyr Lys Ile Asn Tyr Ser Arg Asp Gly Thr Arg 
        115                 120                 125             


Trp Ile Ser Trp Arg Asn Arg His Gly Lys Gln Val Leu Asp Gly Asn 
    130                 135                 140                 


Ser Asn Pro Tyr Asp Ile Phe Leu Lys Asp Leu Glu Pro Pro Ile Val 
145                 150                 155                 160 


Ala Arg Phe Val Arg Phe Ile Pro Val Thr Asp His Ser Met Asn Val 
                165                 170                 175     


Cys Met Arg Val Glu Leu Tyr Gly Cys Val Trp Leu Asp Gly Leu Val 
            180                 185                 190         


Ser Tyr Asn Ala Pro Ala Gly Gln Gln Phe Val Leu Pro Gly Gly Ser 
        195                 200                 205             


Ile Ile Tyr Leu Asn Asp Ser Val Tyr Asp Gly Ala Val Gly Tyr Ser 
    210                 215                 220                 


Met Thr Glu Gly Leu Gly Gln Leu Thr Asp Gly Val Ser Gly Leu Asp 
225                 230                 235                 240 


Asp Phe Thr Gln Thr His Glu Tyr His Val Trp Pro Gly Tyr Asp Tyr 
                245                 250                 255     


Val Gly Trp Arg Asn Glu Ser Ala Thr Asn Gly Tyr Ile Glu Ile Met 
            260                 265                 270         


Phe Glu Phe Asp Arg Ile Arg Asn Phe Thr Thr Met Lys Val His Cys 
        275                 280                 285             


Asn Asn Met Phe Ala Lys Gly Val Lys Ile Phe Lys Glu Val Gln Cys 
    290                 295                 300                 


Tyr Phe Arg Ser Glu Ala Ser Glu Trp Glu Pro Asn Ala Ile Ser Phe 
305                 310                 315                 320 


Pro Leu Val Leu Asp Asp Val Asn Pro Ser Ala Arg Phe Val Thr Val 
                325                 330                 335     


Pro Leu His His Arg Met Ala Ser Ala Ile Lys Cys Gln Tyr His Phe 
            340                 345                 350         


Ala Asp Thr Trp Met Met Phe Ser Glu Ile Thr Phe Gln Ser Asp Ala 
        355                 360                 365             


Ala Met Tyr Asn Asn Ser Glu Ala Leu Pro Thr Ser Pro Met Ala Pro 
    370                 375                 380                 


Thr Thr Tyr Asp Pro Met Leu Lys Val Asp Asp Ser Asn Thr Arg Ile 
385                 390                 395                 400 


Leu Ile Gly Cys Leu Val Ala Ile Ile Phe Ile Leu Leu Ala Ile Ile 
                405                 410                 415     


Val Ile Ile Leu Trp Arg Gln Phe Trp Gln Lys Met Leu Glu Lys Ala 
            420                 425                 430         


Ser Arg Arg Met Leu Asp Asp Glu Met Thr Val Ser Leu Ser Leu Pro 
        435                 440                 445             


Ser Asp Ser Ser Met Phe Asn Asn Asn Arg Ser Ser Ser Pro Ser Glu 
    450                 455                 460                 


Gln Gly Ser Asn Ser Thr Tyr Asp Arg Ile Phe Pro Leu Arg Pro Asp 
465                 470                 475                 480 


Tyr Gln Glu Pro Ser Arg Leu Ile Arg Lys Leu Pro Glu Phe Ala Pro 
                485                 490                 495     


Gly Glu Glu Glu Ser Gly Cys Ser Gly Val Val Lys Pro Val Gln Pro 
            500                 505                 510         


Ser Gly Pro Glu Gly Val Pro His Tyr Ala Glu Ala Asp Ile Val Asn 
        515                 520                 525             


Leu Gln Gly Val Thr Gly Gly Asn Thr Tyr Ser Val Pro Ala Val Thr 
    530                 535                 540                 


Met Asp Leu Leu Ser Gly Lys Asp Val Ala Val Glu Glu Phe Pro Arg 
545                 550                 555                 560 


Lys Leu Leu Thr Phe Lys Glu Lys Leu Gly Glu Gly Gln Phe Gly Glu 
                565                 570                 575     


Val His Leu Cys Glu Val Glu Gly Met Glu Lys Phe Lys Asp Lys Asp 
            580                 585                 590         


Phe Ala Leu Asp Val Ser Ala Asn Gln Pro Val Leu Val Ala Val Lys 
        595                 600                 605             


Met Leu Arg Ala Asp Ala Asn Lys Asn Ala Arg Asn Asp Phe Leu Lys 
    610                 615                 620                 


Glu Ile Lys Ile Met Ser Arg Leu Lys Asp Pro Asn Ile Ile His Leu 
625                 630                 635                 640 


Leu Ala Val Cys Ile Thr Asp Asp Pro Leu Cys Met Ile Thr Glu Tyr 
                645                 650                 655     


Met Glu Asn Gly Asp Leu Asn Gln Phe Leu Ser Arg His Glu Pro Pro 
            660                 665                 670         


Asn Ser Ser Ser Ser Asp Val Arg Thr Val Ser Tyr Thr Asn Leu Lys 
        675                 680                 685             


Phe Met Ala Thr Gln Ile Ala Ser Gly Met Lys Tyr Leu Ser Ser Leu 
    690                 695                 700                 


Asn Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Lys 
705                 710                 715                 720 


Asn Tyr Thr Ile Lys Ile Ala Asp Phe Gly Met Ser Arg Asn Leu Tyr 
                725                 730                 735     


Ser Gly Asp Tyr Tyr Arg Ile Gln Gly Arg Ala Val Leu Pro Ile Arg 
            740                 745                 750         


Trp Met Ser Trp Glu Ser Ile Leu Leu Gly Lys Phe Thr Thr Ala Ser 
        755                 760                 765             


Asp Val Trp Ala Phe Gly Val Thr Leu Trp Glu Thr Phe Thr Phe Cys 
    770                 775                 780                 


Gln Glu Gln Pro Tyr Ser Gln Leu Ser Asp Glu Gln Val Ile Glu Asn 
785                 790                 795                 800 


Thr Gly Glu Phe Phe Arg Asp Gln Gly Arg Gln Thr Tyr Leu Pro Gln 
                805                 810                 815     


Pro Ala Ile Cys Pro Asp Ser Val Tyr Lys Leu Met Leu Ser Cys Trp 
            820                 825                 830         


Arg Arg Asp Thr Lys Asn Arg Pro Ser Phe Gln Glu Ile His Leu Leu 
        835                 840                 845             


Leu Leu Gln Gln Gly Asp Glu 
    850                 855 


<210>  4074
<211>  171
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4074

Xaa Ile Phe Ile Leu Leu Ala Ile Ile Val Ile Ile Leu Trp Arg Gln 
1               5                   10                  15      


Phe Trp Gln Lys Met Leu Glu Lys Ala Ser Arg Arg Met Leu Asp Asp 
            20                  25                  30          


Glu Met Thr Val Ser Leu Ser Leu Pro Ser Asp Ser Ser Met Phe Asn 
        35                  40                  45              


Asn Asn Arg Ser Ser Ser Pro Ser Glu Gln Gly Ser Asn Ser Thr Tyr 
    50                  55                  60                  


Asp Arg Ile Phe Pro Leu Arg Pro Asp Tyr Gln Glu Pro Ser Arg Leu 
65                  70                  75                  80  


Ile Arg Lys Leu Pro Glu Phe Ala Pro Gly Glu Glu Glu Ser Gly Cys 
                85                  90                  95      


Ser Gly Val Val Lys Pro Val Gln Pro Ser Gly Pro Glu Gly Val Pro 
            100                 105                 110         


His Tyr Ala Glu Ala Asp Ile Val Asn Leu Gln Gly Val Thr Gly Gly 
        115                 120                 125             


Asn Thr Tyr Ser Val Pro Ala Val Thr Met Asp Leu Leu Ser Gly Lys 
    130                 135                 140                 


Asp Val Ala Val Glu Glu Phe Pro Arg Lys Leu Leu Thr Phe Lys Glu 
145                 150                 155                 160 


Lys Leu Gly Glu Gly Gln Phe Gly Glu Val Ser 
                165                 170     


<210>  4075
<211>  166
<212>  PRT
<213>  Homo Sapiens

<400>  4075

Met Pro Phe Leu Glu Leu Asp Thr Asn Leu Pro Ala Asn Arg Val Pro 
1               5                   10                  15      


Ala Gly Leu Glu Lys Arg Leu Cys Ala Ala Ala Ala Ser Ile Leu Gly 
            20                  25                  30          


Lys Pro Ala Asp Arg Val Asn Val Thr Val Arg Pro Gly Leu Ala Met 
        35                  40                  45              


Ala Leu Ser Gly Ser Thr Glu Pro Cys Ala Gln Leu Ser Ile Ser Ser 
    50                  55                  60                  


Ile Gly Val Val Gly Thr Ala Glu Asp Asn Arg Ser His Ser Ala His 
65                  70                  75                  80  


Phe Phe Glu Phe Leu Thr Lys Glu Leu Ala Leu Gly Gln Asp Arg Phe 
                85                  90                  95      


Gln Val Lys Phe Thr Gly Asp Ser Gln Ser Ser Glu Arg Pro Leu Ala 
            100                 105                 110         


Trp Met Ser Arg His Leu Leu Ser Gly Ser Cys Ile Ala Gly Gly Pro 
        115                 120                 125             


Gln Thr Asn Leu Glu Met Asn His Leu Gln Leu Ala Thr Ser Ser Ser 
    130                 135                 140                 


Val Asn Thr Gly Glu Lys Thr Ser Leu Pro His Lys Lys Arg Leu Gln 
145                 150                 155                 160 


Pro Lys Pro Gly Val Leu 
                165     


<210>  4076
<211>  118
<212>  PRT
<213>  Homo Sapiens

<400>  4076

Met Pro Phe Leu Glu Leu Asp Thr Asn Leu Pro Ala Asn Arg Val Pro 
1               5                   10                  15      


Ala Gly Leu Glu Lys Arg Leu Cys Ala Ala Ala Ala Ser Ile Leu Gly 
            20                  25                  30          


Lys Pro Ala Asp Arg Val Asn Val Thr Val Arg Pro Gly Leu Ala Met 
        35                  40                  45              


Ala Leu Ser Gly Ser Thr Glu Pro Cys Ala Gln Leu Ser Ile Ser Ser 
    50                  55                  60                  


Ile Gly Val Val Gly Thr Ala Glu Asp Asn Arg Ser His Ser Ala His 
65                  70                  75                  80  


Phe Phe Glu Phe Leu Thr Lys Glu Leu Ala Leu Gly Gln Asp Arg Ile 
                85                  90                  95      


Leu Ile Arg Phe Phe Pro Leu Glu Ser Trp Gln Ile Gly Lys Ile Gly 
            100                 105                 110         


Thr Val Met Thr Phe Leu 
        115             


<210>  4077
<211>  118
<212>  PRT
<213>  Homo Sapiens

<400>  4077

Met Pro Phe Leu Glu Leu Asp Thr Asn Leu Pro Ala Asn Arg Val Pro 
1               5                   10                  15      


Ala Gly Leu Glu Lys Arg Leu Cys Ala Ala Ala Ala Ser Ile Leu Gly 
            20                  25                  30          


Lys Pro Ala Asp Arg Val Asn Val Thr Val Arg Pro Gly Leu Ala Met 
        35                  40                  45              


Ala Leu Ser Gly Ser Thr Glu Pro Cys Ala Gln Leu Ser Ile Ser Ser 
    50                  55                  60                  


Ile Gly Val Val Gly Thr Ala Glu Asp Asn Arg Ser His Ser Ala His 
65                  70                  75                  80  


Phe Phe Glu Phe Leu Thr Lys Glu Leu Ala Leu Gly Gln Asp Arg Ile 
                85                  90                  95      


Leu Ile Arg Phe Phe Pro Leu Glu Ser Trp Gln Ile Gly Lys Ile Gly 
            100                 105                 110         


Thr Val Met Thr Phe Leu 
        115             


<210>  4078
<211>  107
<212>  PRT
<213>  Homo Sapiens

<400>  4078

Met Pro Phe Leu Glu Leu Asp Thr Asn Leu Pro Ala Asn Arg Val Pro 
1               5                   10                  15      


Ala Gly Leu Glu Lys Arg Leu Cys Ala Ala Ala Ala Ser Ile Leu Gly 
            20                  25                  30          


Lys Pro Ala Asp Arg Val Asn Val Thr Val Arg Pro Gly Leu Ala Met 
        35                  40                  45              


Ala Leu Ser Gly Ser Thr Glu Pro Cys Ala Gln Leu Ser Ile Ser Ser 
    50                  55                  60                  


Ile Gly Val Val Gly Thr Ala Glu Asp Asn Arg Ser His Ser Ala His 
65                  70                  75                  80  


Phe Phe Glu Phe Leu Thr Lys Glu Leu Ala Leu Gly Gln Asp Arg Gln 
                85                  90                  95      


Val Pro Gly Glu Val His Gly Arg Leu Thr Glu 
            100                 105         


<210>  4079
<211>  132
<212>  PRT
<213>  Homo Sapiens

<400>  4079

Met Gln Leu Phe Leu Leu Ala Val Ser Val Pro Leu Pro Ala Met Pro 
1               5                   10                  15      


Phe Leu Glu Leu Asp Thr Asn Leu Pro Ala Asn Arg Val Pro Ala Gly 
            20                  25                  30          


Leu Glu Lys Arg Leu Cys Ala Ala Ala Ala Ser Ile Leu Gly Lys Pro 
        35                  40                  45              


Ala Asp Arg Val Asn Val Thr Val Arg Pro Gly Leu Ala Met Ala Leu 
    50                  55                  60                  


Ser Gly Ser Thr Glu Pro Cys Ala Gln Leu Ser Ile Ser Ser Ile Gly 
65                  70                  75                  80  


Val Val Gly Thr Ala Glu Asp Asn Arg Ser His Ser Ala His Phe Phe 
                85                  90                  95      


Glu Phe Leu Thr Lys Glu Leu Ala Leu Gly Gln Asp Arg Ile Leu Ile 
            100                 105                 110         


Arg Phe Phe Pro Leu Glu Ser Trp Gln Ile Gly Lys Ile Gly Thr Val 
        115                 120                 125             


Met Thr Phe Leu 
    130         


<210>  4080
<211>  50
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4080

Xaa Lys Asp Leu Pro Pro Pro Gln Glu Ala Ser Ala Thr Gln Thr Trp 
1               5                   10                  15      


Arg Ser Val Thr Glu Leu Lys Phe Pro Leu Gly Ile Leu Ile Arg Phe 
            20                  25                  30          


Phe Pro Leu Glu Ser Trp Gln Ile Gly Lys Ile Gly Thr Val Met Thr 
        35                  40                  45              


Phe Leu 
    50  


<210>  4081
<211>  729
<212>  PRT
<213>  Homo Sapiens

<400>  4081

Leu Pro Thr Gly Phe Val Ala Pro Ile Leu Cys Val Leu Leu Pro Ser 
1               5                   10                  15      


Pro Thr Arg Glu Ala Ala Thr Val Ala Ser Ala Thr Gly Asp Ser Ala 
            20                  25                  30          


Ser Glu Arg Glu Ser Ala Ala Pro Ala Ala Ala Pro Thr Ala Glu Ala 
        35                  40                  45              


Pro Pro Pro Ser Val Val Thr Arg Pro Glu Pro Gln Ala Leu Pro Ser 
    50                  55                  60                  


Pro Ala Ile Arg Ala Pro Leu Pro Asp Leu Tyr Pro Phe Gly Thr Met 
65                  70                  75                  80  


Arg Gly Gly Gly Phe Gly Asp Arg Asp Arg Asp Arg Asp Arg Gly Gly 
                85                  90                  95      


Phe Gly Ala Arg Gly Gly Gly Gly Leu Pro Pro Lys Lys Phe Gly Asn 
            100                 105                 110         


Pro Gly Glu Arg Leu Arg Lys Lys Lys Trp Asp Leu Ser Glu Leu Pro 
        115                 120                 125             


Lys Phe Glu Lys Asn Phe Tyr Val Glu His Pro Glu Val Ala Arg Leu 
    130                 135                 140                 


Thr Pro Tyr Glu Val Asp Glu Leu Arg Arg Lys Lys Glu Ile Thr Val 
145                 150                 155                 160 


Arg Gly Gly Asp Val Cys Pro Lys Pro Val Phe Ala Phe His His Ala 
                165                 170                 175     


Asn Phe Pro Gln Tyr Val Met Asp Val Leu Met Asp Gln His Phe Thr 
            180                 185                 190         


Glu Pro Thr Pro Ile Gln Cys Gln Gly Phe Pro Leu Ala Leu Ser Gly 
        195                 200                 205             


Arg Asp Met Val Gly Ile Ala Gln Thr Gly Ser Gly Lys Thr Leu Ala 
    210                 215                 220                 


Tyr Leu Leu Pro Ala Ile Val His Ile Asn His Gln Pro Tyr Leu Glu 
225                 230                 235                 240 


Arg Gly Asp Gly Pro Ile Cys Leu Val Leu Ala Pro Thr Arg Glu Leu 
                245                 250                 255     


Ala Gln Gln Val Gln Gln Val Ala Asp Asp Tyr Gly Lys Cys Ser Arg 
            260                 265                 270         


Leu Lys Ser Thr Cys Ile Tyr Gly Gly Ala Pro Lys Gly Pro Gln Ile 
        275                 280                 285             


Arg Asp Leu Glu Arg Gly Val Glu Ile Cys Ile Ala Thr Pro Gly Arg 
    290                 295                 300                 


Leu Ile Asp Phe Leu Glu Ser Gly Lys Thr Asn Leu Arg Arg Cys Thr 
305                 310                 315                 320 


Tyr Leu Val Leu Asp Glu Ala Asp Arg Met Leu Asp Met Gly Phe Glu 
                325                 330                 335     


Pro Gln Ile Arg Lys Ile Val Asp Gln Ile Arg Pro Asp Arg Gln Thr 
            340                 345                 350         


Leu Met Trp Ser Ala Thr Trp Pro Lys Glu Val Arg Gln Leu Ala Glu 
        355                 360                 365             


Asp Phe Leu Arg Asp Tyr Thr Gln Ile Asn Val Gly Asn Leu Glu Leu 
    370                 375                 380                 


Ser Ala Asn His Asn Ile Leu Gln Ile Val Asp Val Cys Met Glu Ser 
385                 390                 395                 400 


Glu Lys Asp His Lys Leu Ile Gln Leu Met Glu Glu Ile Met Ala Glu 
                405                 410                 415     


Lys Glu Asn Lys Thr Ile Ile Phe Val Glu Thr Lys Arg Arg Cys Asp 
            420                 425                 430         


Asp Leu Thr Arg Arg Met Arg Arg Asp Gly Trp Pro Ala Met Cys Ile 
        435                 440                 445             


His Gly Asp Lys Ser Gln Pro Glu Arg Asp Trp Val Leu Asn Glu Phe 
    450                 455                 460                 


Arg Ser Gly Lys Ala Pro Ile Leu Ile Ala Thr Asp Val Ala Ser Arg 
465                 470                 475                 480 


Gly Leu Asp Val Glu Asp Val Lys Phe Val Ile Asn Tyr Asp Tyr Pro 
                485                 490                 495     


Asn Ser Ser Glu Asp Tyr Val His Arg Ile Gly Arg Thr Ala Arg Ser 
            500                 505                 510         


Thr Asn Lys Gly Thr Ala Tyr Thr Phe Phe Thr Pro Gly Asn Leu Lys 
        515                 520                 525             


Gln Ala Arg Glu Leu Ile Lys Val Leu Glu Glu Ala Asn Gln Ala Ile 
    530                 535                 540                 


Asn Pro Lys Leu Met Gln Leu Val Asp His Arg Gly Gly Gly Gly Gly 
545                 550                 555                 560 


Gly Gly Gly Arg Ser Arg Tyr Arg Thr Thr Ser Ser Ala Asn Asn Pro 
                565                 570                 575     


Asn Leu Met Tyr Gln Asp Glu Cys Asp Arg Arg Leu Arg Gly Val Lys 
            580                 585                 590         


Asp Gly Gly Arg Arg Asp Ser Ala Ser Tyr Arg Asp Arg Ser Glu Thr 
        595                 600                 605             


Asp Arg Ala Gly Tyr Ala Asn Gly Ser Gly Tyr Gly Ser Pro Asn Ser 
    610                 615                 620                 


Ala Phe Gly Ala Gln Ala Gly Gln Tyr Thr Tyr Gly Gln Gly Thr Tyr 
625                 630                 635                 640 


Gly Ala Ala Ala Tyr Gly Thr Ser Ser Tyr Thr Ala Gln Glu Tyr Gly 
                645                 650                 655     


Ala Gly Thr Tyr Gly Ala Ser Ser Thr Thr Ser Thr Gly Arg Ser Ser 
            660                 665                 670         


Gln Ser Ser Ser Gln Gln Phe Ser Gly Ile Gly Arg Ser Gly Gln Gln 
        675                 680                 685             


Pro Gln Pro Leu Met Ser Gln Gln Phe Ala Gln Pro Pro Gly Ala Thr 
    690                 695                 700                 


Asn Met Ile Gly Tyr Met Gly Gln Thr Ala Tyr Gln Tyr Pro Pro Pro 
705                 710                 715                 720 


Pro Pro Pro Pro Pro Pro Ser Arg Lys 
                725                 


<210>  4082
<211>  731
<212>  PRT
<213>  Homo Sapiens

<400>  4082

Leu Pro Thr Gly Phe Val Ala Pro Ile Leu Cys Val Leu Leu Pro Ser 
1               5                   10                  15      


Pro Thr Arg Glu Ala Ala Thr Val Ala Ser Ala Thr Gly Asp Ser Ala 
            20                  25                  30          


Ser Glu Arg Glu Ser Ala Ala Pro Ala Ala Ala Pro Thr Ala Glu Ala 
        35                  40                  45              


Pro Pro Pro Ser Val Val Thr Arg Pro Glu Pro Gln Ala Leu Pro Ser 
    50                  55                  60                  


Pro Ala Ile Arg Ala Pro Leu Pro Asp Leu Tyr Pro Phe Gly Thr Met 
65                  70                  75                  80  


Arg Gly Gly Gly Phe Gly Asp Arg Asp Arg Asp Arg Asp Arg Gly Gly 
                85                  90                  95      


Phe Gly Ala Arg Gly Gly Gly Gly Leu Pro Pro Lys Lys Phe Gly Asn 
            100                 105                 110         


Pro Gly Glu Arg Leu Arg Lys Lys Lys Trp Asp Leu Ser Glu Leu Pro 
        115                 120                 125             


Lys Phe Glu Lys Asn Phe Tyr Val Glu His Pro Glu Val Ala Arg Leu 
    130                 135                 140                 


Thr Pro Tyr Glu Val Asp Glu Leu Arg Arg Lys Lys Glu Ile Thr Val 
145                 150                 155                 160 


Arg Gly Gly Asp Val Cys Pro Lys Pro Val Phe Ala Phe His His Ala 
                165                 170                 175     


Asn Phe Pro Gln Tyr Val Met Asp Val Leu Met Asp Gln His Phe Thr 
            180                 185                 190         


Glu Pro Thr Pro Ile Gln Cys Gln Gly Phe Pro Leu Ala Leu Ser Gly 
        195                 200                 205             


Arg Asp Met Val Gly Ile Ala Gln Thr Gly Ser Gly Lys Thr Leu Ala 
    210                 215                 220                 


Tyr Leu Leu Pro Ala Ile Val His Ile Asn His Gln Pro Tyr Leu Glu 
225                 230                 235                 240 


Arg Gly Asp Gly Pro Ile Cys Leu Val Leu Ala Pro Thr Arg Glu Leu 
                245                 250                 255     


Ala Gln Gln Val Gln Gln Val Ala Asp Asp Tyr Gly Lys Cys Ser Arg 
            260                 265                 270         


Leu Lys Ser Thr Cys Ile Tyr Gly Gly Ala Pro Lys Gly Pro Gln Ile 
        275                 280                 285             


Arg Asp Leu Glu Arg Gly Val Glu Ile Cys Ile Ala Thr Pro Gly Arg 
    290                 295                 300                 


Leu Ile Asp Phe Leu Glu Ser Gly Lys Thr Asn Leu Arg Arg Cys Thr 
305                 310                 315                 320 


Tyr Leu Val Leu Asp Glu Ala Asp Arg Met Leu Asp Met Gly Phe Glu 
                325                 330                 335     


Pro Gln Ile Arg Lys Ile Val Asp Gln Ile Arg Pro Asp Arg Gln Thr 
            340                 345                 350         


Leu Met Trp Ser Ala Thr Trp Pro Lys Glu Val Arg Gln Leu Ala Glu 
        355                 360                 365             


Asp Phe Leu Arg Asp Tyr Thr Gln Ile Asn Val Gly Asn Leu Glu Leu 
    370                 375                 380                 


Ser Ala Asn His Asn Ile Leu Gln Ile Val Asp Val Cys Met Glu Ser 
385                 390                 395                 400 


Glu Lys Asp His Lys Leu Ile Gln Leu Met Glu Glu Ile Met Ala Glu 
                405                 410                 415     


Lys Glu Asn Lys Thr Ile Ile Phe Val Glu Thr Lys Arg Arg Cys Asp 
            420                 425                 430         


Asp Leu Thr Arg Arg Met Arg Arg Asp Gly Trp Pro Ala Met Cys Ile 
        435                 440                 445             


His Gly Asp Lys Ser Gln Pro Glu Arg Asp Trp Val Leu Asn Glu Phe 
    450                 455                 460                 


Arg Ser Gly Lys Ala Pro Ile Leu Ile Ala Thr Asp Val Ala Ser Arg 
465                 470                 475                 480 


Gly Leu Asp Val Glu Asp Val Lys Phe Val Ile Asn Tyr Asp Tyr Pro 
                485                 490                 495     


Asn Ser Ser Glu Asp Tyr Val His Arg Ile Gly Arg Thr Ala Arg Ser 
            500                 505                 510         


Thr Asn Lys Gly Thr Ala Tyr Thr Phe Phe Thr Pro Gly Asn Leu Lys 
        515                 520                 525             


Gln Ala Arg Glu Leu Ile Lys Val Leu Glu Glu Ala Asn Gln Ala Ile 
    530                 535                 540                 


Asn Pro Lys Leu Met Gln Leu Val Asp His Arg Gly Gly Gly Gly Gly 
545                 550                 555                 560 


Gly Gly Lys Gly Gly Arg Ser Arg Tyr Arg Thr Thr Ser Ser Ala Asn 
                565                 570                 575     


Asn Pro Asn Leu Met Tyr Gln Asp Glu Cys Asp Arg Arg Leu Arg Gly 
            580                 585                 590         


Val Lys Asp Gly Gly Arg Arg Asp Ser Ala Ser Tyr Arg Asp Arg Ser 
        595                 600                 605             


Glu Thr Asp Arg Ala Gly Tyr Ala Asn Gly Ser Gly Tyr Gly Ser Pro 
    610                 615                 620                 


Asn Ser Ala Phe Gly Ala Gln Ala Gly Gln Tyr Thr Tyr Gly Gln Gly 
625                 630                 635                 640 


Thr Tyr Gly Ala Ala Ala Tyr Gly Thr Ser Ser Tyr Thr Ala Gln Glu 
                645                 650                 655     


Tyr Gly Ala Gly Thr Tyr Gly Ala Ser Ser Thr Thr Ser Thr Gly Arg 
            660                 665                 670         


Ser Ser Gln Ser Ser Ser Gln Gln Phe Ser Gly Ile Gly Arg Ser Gly 
        675                 680                 685             


Gln Gln Pro Gln Pro Leu Met Ser Gln Gln Phe Ala Gln Pro Pro Gly 
    690                 695                 700                 


Ala Thr Asn Met Ile Gly Tyr Met Gly Gln Thr Ala Tyr Gln Tyr Pro 
705                 710                 715                 720 


Pro Pro Pro Pro Pro Pro Pro Pro Ser Arg Lys 
                725                 730     


<210>  4083
<211>  729
<212>  PRT
<213>  Homo Sapiens

<400>  4083

Leu Pro Thr Gly Phe Val Ala Pro Ile Leu Cys Val Leu Leu Pro Ser 
1               5                   10                  15      


Pro Thr Arg Glu Ala Ala Thr Val Ala Ser Ala Thr Gly Asp Ser Ala 
            20                  25                  30          


Ser Glu Arg Glu Ser Ala Ala Pro Ala Ala Ala Pro Thr Ala Glu Ala 
        35                  40                  45              


Pro Pro Pro Ser Val Val Thr Arg Pro Glu Pro Gln Ala Leu Pro Ser 
    50                  55                  60                  


Pro Ala Ile Arg Ala Pro Leu Pro Asp Leu Tyr Pro Phe Gly Thr Met 
65                  70                  75                  80  


Arg Gly Gly Gly Phe Gly Asp Arg Asp Arg Asp Arg Asp Arg Gly Gly 
                85                  90                  95      


Phe Gly Ala Arg Gly Gly Gly Gly Leu Pro Pro Lys Lys Phe Gly Asn 
            100                 105                 110         


Pro Gly Glu Arg Leu Arg Lys Lys Lys Trp Asp Leu Ser Glu Leu Pro 
        115                 120                 125             


Lys Phe Glu Lys Asn Phe Tyr Val Glu His Pro Glu Val Ala Arg Leu 
    130                 135                 140                 


Thr Pro Tyr Glu Val Asp Glu Leu Arg Arg Lys Lys Glu Ile Thr Val 
145                 150                 155                 160 


Arg Gly Gly Asp Val Cys Pro Lys Pro Val Phe Ala Phe His His Ala 
                165                 170                 175     


Asn Phe Pro Gln Tyr Val Met Asp Val Leu Met Asp Gln His Phe Thr 
            180                 185                 190         


Glu Pro Thr Pro Ile Gln Cys Gln Gly Phe Pro Leu Ala Leu Ser Gly 
        195                 200                 205             


Arg Asp Met Val Gly Ile Ala Gln Thr Gly Ser Gly Lys Thr Leu Ala 
    210                 215                 220                 


Tyr Leu Leu Pro Ala Ile Val His Ile Asn His Gln Pro Tyr Leu Glu 
225                 230                 235                 240 


Arg Gly Asp Gly Pro Ile Cys Leu Val Leu Ala Pro Thr Arg Glu Leu 
                245                 250                 255     


Ala Gln Gln Val Gln Gln Val Ala Asp Asp Tyr Gly Lys Cys Ser Arg 
            260                 265                 270         


Leu Lys Ser Thr Cys Ile Tyr Gly Gly Ala Pro Lys Gly Pro Gln Ile 
        275                 280                 285             


Arg Asp Leu Glu Arg Gly Val Glu Ile Cys Ile Ala Thr Pro Gly Arg 
    290                 295                 300                 


Leu Ile Asp Phe Leu Glu Ser Gly Lys Thr Asn Leu Arg Arg Cys Thr 
305                 310                 315                 320 


Tyr Leu Val Leu Asp Glu Ala Asp Arg Met Leu Asp Met Gly Phe Glu 
                325                 330                 335     


Pro Gln Ile Arg Lys Ile Val Asp Gln Ile Arg Pro Asp Arg Gln Thr 
            340                 345                 350         


Leu Met Trp Ser Ala Thr Trp Pro Lys Glu Val Arg Gln Leu Ala Glu 
        355                 360                 365             


Asp Phe Leu Arg Asp Tyr Thr Gln Ile Asn Val Gly Asn Leu Glu Leu 
    370                 375                 380                 


Ser Ala Asn His Asn Ile Leu Gln Ile Val Asp Val Cys Met Glu Ser 
385                 390                 395                 400 


Glu Lys Asp His Lys Leu Ile Gln Leu Met Glu Glu Ile Met Ala Glu 
                405                 410                 415     


Lys Glu Asn Lys Thr Ile Ile Phe Val Glu Thr Lys Arg Arg Cys Asp 
            420                 425                 430         


Asp Leu Thr Arg Arg Met Arg Arg Asp Gly Trp Pro Ala Met Cys Ile 
        435                 440                 445             


His Gly Asp Lys Ser Gln Pro Glu Arg Asp Trp Val Leu Asn Glu Phe 
    450                 455                 460                 


Arg Ser Gly Lys Ala Pro Ile Leu Ile Ala Thr Asp Val Ala Ser Arg 
465                 470                 475                 480 


Gly Leu Asp Val Glu Asp Val Lys Phe Val Ile Asn Tyr Asp Tyr Pro 
                485                 490                 495     


Asn Ser Ser Glu Asp Tyr Val His Arg Ile Gly Arg Thr Ala Arg Ser 
            500                 505                 510         


Thr Asn Lys Gly Thr Ala Tyr Thr Phe Phe Thr Pro Gly Asn Leu Lys 
        515                 520                 525             


Gln Ala Arg Glu Leu Ile Lys Val Leu Glu Glu Ala Asn Gln Ala Ile 
    530                 535                 540                 


Asn Pro Lys Leu Met Gln Leu Val Asp His Arg Gly Gly Gly Gly Gly 
545                 550                 555                 560 


Gly Gly Gly Arg Ser Arg Tyr Arg Thr Thr Ser Ser Ala Asn Asn Pro 
                565                 570                 575     


Asn Leu Met Tyr Gln Asp Glu Cys Asp Arg Arg Leu Arg Gly Val Lys 
            580                 585                 590         


Asp Gly Gly Arg Arg Asp Ser Ala Ser Tyr Arg Asp Arg Ser Glu Thr 
        595                 600                 605             


Asp Arg Ala Gly Tyr Ala Asn Gly Ser Gly Tyr Gly Ser Pro Asn Ser 
    610                 615                 620                 


Ala Phe Gly Ala Gln Ala Gly Gln Tyr Thr Tyr Gly Gln Gly Thr Tyr 
625                 630                 635                 640 


Gly Ala Ala Ala Tyr Gly Thr Ser Ser Tyr Thr Ala Gln Glu Tyr Gly 
                645                 650                 655     


Ala Gly Thr Tyr Gly Ala Ser Ser Thr Thr Ser Thr Gly Arg Ser Ser 
            660                 665                 670         


Gln Ser Ser Ser Gln Gln Phe Ser Gly Ile Gly Arg Ser Gly Gln Gln 
        675                 680                 685             


Pro Gln Pro Leu Met Ser Gln Gln Phe Ala Gln Pro Pro Gly Ala Thr 
    690                 695                 700                 


Asn Met Ile Gly Tyr Met Gly Gln Thr Ala Tyr Gln Tyr Pro Pro Pro 
705                 710                 715                 720 


Pro Pro Pro Pro Pro Pro Ser Arg Lys 
                725                 


<210>  4084
<211>  731
<212>  PRT
<213>  Homo Sapiens

<400>  4084

Leu Pro Thr Gly Phe Val Ala Pro Ile Leu Cys Val Leu Leu Pro Ser 
1               5                   10                  15      


Pro Thr Arg Glu Ala Ala Thr Val Ala Ser Ala Thr Gly Asp Ser Ala 
            20                  25                  30          


Ser Glu Arg Glu Ser Ala Ala Pro Ala Ala Ala Pro Thr Ala Glu Ala 
        35                  40                  45              


Pro Pro Pro Ser Val Val Thr Arg Pro Glu Pro Gln Ala Leu Pro Ser 
    50                  55                  60                  


Pro Ala Ile Arg Ala Pro Leu Pro Asp Leu Tyr Pro Phe Gly Thr Met 
65                  70                  75                  80  


Arg Gly Gly Gly Phe Gly Asp Arg Asp Arg Asp Arg Asp Arg Gly Gly 
                85                  90                  95      


Phe Gly Ala Arg Gly Gly Gly Gly Leu Pro Pro Lys Lys Phe Gly Asn 
            100                 105                 110         


Pro Gly Glu Arg Leu Arg Lys Lys Lys Trp Asp Leu Ser Glu Leu Pro 
        115                 120                 125             


Lys Phe Glu Lys Asn Phe Tyr Val Glu His Pro Glu Val Ala Arg Leu 
    130                 135                 140                 


Thr Pro Tyr Glu Val Asp Glu Leu Arg Arg Lys Lys Glu Ile Thr Val 
145                 150                 155                 160 


Arg Gly Gly Asp Val Cys Pro Lys Pro Val Phe Ala Phe His His Ala 
                165                 170                 175     


Asn Phe Pro Gln Tyr Val Met Asp Val Leu Met Asp Gln His Phe Thr 
            180                 185                 190         


Glu Pro Thr Pro Ile Gln Cys Gln Gly Phe Pro Leu Ala Leu Ser Gly 
        195                 200                 205             


Arg Asp Met Val Gly Ile Ala Gln Thr Gly Ser Gly Lys Thr Leu Ala 
    210                 215                 220                 


Tyr Leu Leu Pro Ala Ile Val His Ile Asn His Gln Pro Tyr Leu Glu 
225                 230                 235                 240 


Arg Gly Asp Gly Pro Ile Cys Leu Val Leu Ala Pro Thr Arg Glu Leu 
                245                 250                 255     


Ala Gln Gln Val Gln Gln Val Ala Asp Asp Tyr Gly Lys Cys Ser Arg 
            260                 265                 270         


Leu Lys Ser Thr Cys Ile Tyr Gly Gly Ala Pro Lys Gly Pro Gln Ile 
        275                 280                 285             


Arg Asp Leu Glu Arg Gly Val Glu Ile Cys Ile Ala Thr Pro Gly Arg 
    290                 295                 300                 


Leu Ile Asp Phe Leu Glu Ser Gly Lys Thr Asn Leu Arg Arg Cys Thr 
305                 310                 315                 320 


Tyr Leu Val Leu Asp Glu Ala Asp Arg Met Leu Asp Met Gly Phe Glu 
                325                 330                 335     


Pro Gln Ile Arg Lys Ile Val Asp Gln Ile Arg Pro Asp Arg Gln Thr 
            340                 345                 350         


Leu Met Trp Ser Ala Thr Trp Pro Lys Glu Val Arg Gln Leu Ala Glu 
        355                 360                 365             


Asp Phe Leu Arg Asp Tyr Thr Gln Ile Asn Val Gly Asn Leu Glu Leu 
    370                 375                 380                 


Ser Ala Asn His Asn Ile Leu Gln Ile Val Asp Val Cys Met Glu Ser 
385                 390                 395                 400 


Glu Lys Asp His Lys Leu Ile Gln Leu Met Glu Glu Ile Met Ala Glu 
                405                 410                 415     


Lys Glu Asn Lys Thr Ile Ile Phe Val Glu Thr Lys Arg Arg Cys Asp 
            420                 425                 430         


Asp Leu Thr Arg Arg Met Arg Arg Asp Gly Trp Pro Ala Met Cys Ile 
        435                 440                 445             


His Gly Asp Lys Ser Gln Pro Glu Arg Asp Trp Val Leu Asn Glu Phe 
    450                 455                 460                 


Arg Ser Gly Lys Ala Pro Ile Leu Ile Ala Thr Asp Val Ala Ser Arg 
465                 470                 475                 480 


Gly Leu Asp Val Glu Asp Val Lys Phe Val Ile Asn Tyr Asp Tyr Pro 
                485                 490                 495     


Asn Ser Ser Glu Asp Tyr Val His Arg Ile Gly Arg Thr Ala Arg Ser 
            500                 505                 510         


Thr Asn Lys Gly Thr Ala Tyr Thr Phe Phe Thr Pro Gly Asn Leu Lys 
        515                 520                 525             


Gln Ala Arg Glu Leu Ile Lys Val Leu Glu Glu Ala Asn Gln Ala Ile 
    530                 535                 540                 


Asn Pro Lys Leu Met Gln Leu Val Asp His Arg Gly Gly Gly Gly Gly 
545                 550                 555                 560 


Gly Gly Lys Gly Gly Arg Ser Arg Tyr Arg Thr Thr Ser Ser Ala Asn 
                565                 570                 575     


Asn Pro Asn Leu Met Tyr Gln Asp Glu Cys Asp Arg Arg Leu Arg Gly 
            580                 585                 590         


Val Lys Asp Gly Gly Arg Arg Asp Ser Ala Ser Tyr Arg Asp Arg Ser 
        595                 600                 605             


Glu Thr Asp Arg Ala Gly Tyr Ala Asn Gly Ser Gly Tyr Gly Ser Pro 
    610                 615                 620                 


Asn Ser Ala Phe Gly Ala Gln Ala Gly Gln Tyr Thr Tyr Gly Gln Gly 
625                 630                 635                 640 


Thr Tyr Gly Ala Ala Ala Tyr Gly Thr Ser Ser Tyr Thr Ala Gln Glu 
                645                 650                 655     


Tyr Gly Ala Gly Thr Tyr Gly Ala Ser Ser Thr Thr Ser Thr Gly Arg 
            660                 665                 670         


Ser Ser Gln Ser Ser Ser Gln Gln Phe Ser Gly Ile Gly Arg Ser Gly 
        675                 680                 685             


Gln Gln Pro Gln Pro Leu Met Ser Gln Gln Phe Ala Gln Pro Pro Gly 
    690                 695                 700                 


Ala Thr Asn Met Ile Gly Tyr Met Gly Gln Thr Ala Tyr Gln Tyr Pro 
705                 710                 715                 720 


Pro Pro Pro Pro Pro Pro Pro Pro Ser Arg Lys 
                725                 730     


<210>  4085
<211>  56
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4085

Xaa Trp Pro Ala Met Cys Ile His Gly Asp Lys Ser Gln Pro Glu Arg 
1               5                   10                  15      


Asp Trp Val Leu Asn Glu Phe Arg Ser Gly Lys Ala Pro Ile Leu Ile 
            20                  25                  30          


Ala Thr Asp Val Ala Ser Arg Gly Leu Gly Ser Pro Ala Leu Gly Asn 
        35                  40                  45              


Gln Met Gly Leu Gln Arg Ser Ile 
    50                  55      


<210>  4086
<211>  138
<212>  PRT
<213>  Homo Sapiens

<400>  4086

Met Ala Ala Ala Phe Glu Ala Ser Gly Ala Leu Ala Ala Val Ala Thr 
1               5                   10                  15      


Ala Met Pro Ala Glu His Val Ala Val Gln Val Pro Ala Pro Glu Pro 
            20                  25                  30          


Thr Pro Gly Pro Val Arg Ile Leu Arg Thr Ala Gln Asp Leu Ser Ser 
        35                  40                  45              


Pro Arg Thr Arg Thr Gly Asp Val Leu Leu Ala Glu Pro Ala Asp Phe 
    50                  55                  60                  


Glu Ser Leu Leu Leu Ser Arg Pro Val Leu Glu Gly Leu Arg Ala Ala 
65                  70                  75                  80  


Gly Phe Glu Arg Pro Ser Pro Val Gln Leu Lys Ala Ile Pro Leu Gly 
                85                  90                  95      


Arg Cys Gly Leu Asp Leu Ile Val Gln Ala Lys Ser Gly Thr Gly Lys 
            100                 105                 110         


Thr Cys Val Phe Ser Thr Ile Ala Leu Asp Ser Leu Val Leu Glu Asn 
        115                 120                 125             


Leu Ser Thr Gln Ala Glu Leu Ser Asn Ser 
    130                 135             


<210>  4087
<211>  824
<212>  PRT
<213>  Homo Sapiens

<400>  4087

Met Ala Ala Ala Phe Glu Ala Ser Gly Ala Leu Ala Ala Val Ala Thr 
1               5                   10                  15      


Ala Met Pro Ala Glu His Val Ala Val Gln Val Pro Ala Pro Glu Pro 
            20                  25                  30          


Thr Pro Gly Pro Val Arg Ile Leu Arg Thr Ala Gln Asp Leu Ser Ser 
        35                  40                  45              


Pro Arg Thr Arg Thr Gly Asp Val Leu Leu Ala Glu Pro Ala Asp Phe 
    50                  55                  60                  


Glu Ser Leu Leu Leu Ser Arg Pro Val Leu Glu Gly Leu Arg Ala Ala 
65                  70                  75                  80  


Gly Phe Glu Arg Pro Ser Pro Val Gln Leu Lys Ala Ile Pro Leu Gly 
                85                  90                  95      


Arg Cys Gly Leu Asp Leu Ile Val Gln Ala Lys Ser Gly Thr Gly Lys 
            100                 105                 110         


Thr Cys Val Phe Ser Thr Ile Ala Leu Asp Ser Leu Val Leu Glu Asn 
        115                 120                 125             


Leu Ser Thr Gln Ile Leu Ile Leu Ala Pro Thr Arg Glu Ile Ala Val 
    130                 135                 140                 


Gln Ile His Ser Val Ile Thr Ala Ile Gly Ile Lys Met Glu Gly Leu 
145                 150                 155                 160 


Glu Cys His Val Phe Ile Gly Gly Thr Pro Leu Ser Gln Asp Lys Thr 
                165                 170                 175     


Arg Leu Lys Lys Cys His Ile Ala Val Gly Ser Pro Gly Arg Ile Lys 
            180                 185                 190         


Gln Leu Ile Glu Leu Asp Tyr Leu Asn Pro Gly Ser Ile Arg Leu Phe 
        195                 200                 205             


Ile Leu Asp Glu Ala Asp Lys Leu Leu Glu Glu Gly Ser Phe Gln Glu 
    210                 215                 220                 


Gln Ile Asn Trp Ile Tyr Ser Ser Leu Pro Ala Ser Lys Gln Met Leu 
225                 230                 235                 240 


Ala Val Ser Ala Thr Tyr Pro Glu Phe Leu Ala Asn Ala Leu Thr Lys 
                245                 250                 255     


Tyr Met Arg Asp Pro Thr Phe Val Arg Leu Asn Ser Ser Asp Pro Ser 
            260                 265                 270         


Leu Ile Gly Leu Lys Gln Tyr Tyr Lys Val Val Asn Ser Tyr Pro Leu 
        275                 280                 285             


Ala His Lys Val Phe Glu Glu Lys Thr Gln His Leu Gln Glu Leu Phe 
    290                 295                 300                 


Ser Arg Ile Pro Phe Asn Gln Ala Leu Val Phe Ser Asn Leu His Ser 
305                 310                 315                 320 


Arg Ala Gln His Leu Ala Asp Ile Leu Ser Ser Lys Gly Phe Pro Ala 
                325                 330                 335     


Glu Cys Ile Ser Gly Asn Met Asn Gln Asn Gln Arg Leu Asp Ala Met 
            340                 345                 350         


Ala Lys Leu Lys His Phe His Cys Arg Val Leu Ile Ser Thr Asp Leu 
        355                 360                 365             


Thr Ser Arg Gly Ile Asp Ala Glu Lys Val Asn Leu Val Val Asn Leu 
    370                 375                 380                 


Asp Val Pro Leu Asp Trp Glu Thr Tyr Met His Arg Ile Gly Arg Ala 
385                 390                 395                 400 


Gly Arg Phe Gly Thr Leu Gly Leu Thr Val Thr Tyr Cys Cys Arg Gly 
                405                 410                 415     


Glu Glu Glu Asn Met Met Met Arg Ile Ala Gln Lys Cys Asn Ile Asn 
            420                 425                 430         


Leu Leu Pro Leu Pro Asp Pro Ile Pro Ser Gly Leu Met Glu Glu Cys 
        435                 440                 445             


Val Asp Trp Asp Val Glu Val Lys Ala Ala Val His Thr Tyr Gly Ile 
    450                 455                 460                 


Ala Ser Val Pro Asn Gln Pro Leu Lys Lys Gln Ile Gln Lys Ile Glu 
465                 470                 475                 480 


Arg Thr Leu Gln Ile Gln Lys Ala His Gly Asp His Met Ala Ser Ser 
                485                 490                 495     


Arg Asn Asn Ser Val Ser Gly Leu Ser Val Lys Ser Lys Asn Asn Thr 
            500                 505                 510         


Lys Gln Lys Leu Pro Val Lys Ser His Ser Glu Cys Gly Ile Ile Glu 
        515                 520                 525             


Lys Ala Thr Ser Pro Lys Glu Leu Gly Cys Asp Arg Gln Ser Glu Glu 
    530                 535                 540                 


Gln Met Lys Asn Ser Val Gln Thr Pro Val Glu Asn Ser Thr Asn Ser 
545                 550                 555                 560 


Gln His Gln Val Lys Glu Ala Leu Pro Val Ser Leu Pro Gln Ile Pro 
                565                 570                 575     


Cys Leu Ser Ser Phe Lys Ile His Gln Pro Tyr Thr Leu Thr Phe Ala 
            580                 585                 590         


Glu Leu Val Glu Asp Tyr Glu His Tyr Ile Lys Glu Gly Leu Glu Lys 
        595                 600                 605             


Pro Val Glu Ile Ile Arg His Tyr Thr Gly Pro Gly Asp Gln Thr Val 
    610                 615                 620                 


Asn Pro Gln Asn Gly Phe Val Arg Asn Lys Val Ile Glu Gln Arg Val 
625                 630                 635                 640 


Pro Val Leu Ala Ser Ser Ser Gln Ser Gly Asp Ser Glu Ser Asp Ser 
                645                 650                 655     


Asp Ser Tyr Ser Ser Arg Thr Ser Ser Gln Ser Lys Gly Asn Lys Ser 
            660                 665                 670         


Tyr Leu Glu Gly Ser Ser Asp Asn Gln Leu Lys Asp Ser Glu Ser Thr 
        675                 680                 685             


Pro Val Asp Asp Arg Ile Ser Leu Glu Gln Pro Pro Asn Gly Ser Asp 
    690                 695                 700                 


Thr Pro Asn Pro Glu Lys Tyr Gln Glu Ser Pro Gly Ile Gln Met Lys 
705                 710                 715                 720 


Thr Arg Leu Lys Glu Gly Ala Ser Gln Arg Ala Lys Gln Ser Arg Arg 
                725                 730                 735     


Asn Leu Pro Arg Arg Ser Ser Phe Arg Leu Gln Thr Glu Ala Gln Glu 
            740                 745                 750         


Asp Asp Trp Tyr Asp Cys His Arg Glu Ile Arg Leu Ser Phe Ser Asp 
        755                 760                 765             


Thr Tyr Gln Asp Tyr Glu Glu Tyr Trp Arg Ala Tyr Tyr Arg Ala Trp 
    770                 775                 780                 


Gln Glu Tyr Tyr Ala Ala Ala Ser His Ser Tyr Tyr Trp Asn Ala Gln 
785                 790                 795                 800 


Arg His Pro Ser Trp Met Ala Ala Tyr His Met Asn Thr Ile Tyr Leu 
                805                 810                 815     


Gln Glu Met Met His Ser Asn Gln 
            820                 


<210>  4088
<211>  432
<212>  PRT
<213>  Homo Sapiens

<400>  4088

Met Ile Tyr Tyr Leu Thr Phe Ser Leu Leu Leu Gly Thr Leu Gly Leu 
1               5                   10                  15      


Thr Val Thr Tyr Cys Cys Arg Gly Glu Glu Glu Asn Met Met Met Arg 
            20                  25                  30          


Ile Ala Gln Lys Cys Asn Ile Asn Leu Leu Pro Leu Pro Asp Pro Ile 
        35                  40                  45              


Pro Ser Gly Leu Met Glu Glu Cys Val Asp Trp Asp Val Glu Val Lys 
    50                  55                  60                  


Ala Ala Val His Thr Tyr Gly Ile Ala Ser Val Pro Asn Gln Pro Leu 
65                  70                  75                  80  


Lys Lys Gln Ile Gln Lys Ile Glu Arg Thr Leu Gln Ile Gln Lys Ala 
                85                  90                  95      


His Gly Asp His Met Ala Ser Ser Arg Asn Asn Ser Val Ser Gly Leu 
            100                 105                 110         


Ser Val Lys Ser Lys Asn Asn Thr Lys Gln Lys Leu Pro Val Lys Ser 
        115                 120                 125             


His Ser Glu Cys Gly Ile Ile Glu Lys Ala Thr Ser Pro Lys Glu Leu 
    130                 135                 140                 


Gly Cys Asp Arg Gln Ser Glu Glu Gln Met Lys Asn Ser Val Gln Thr 
145                 150                 155                 160 


Pro Val Glu Asn Ser Thr Asn Ser Gln His Gln Val Lys Glu Ala Leu 
                165                 170                 175     


Pro Val Ser Leu Pro Gln Ile Pro Cys Leu Ser Ser Phe Lys Ile His 
            180                 185                 190         


Gln Pro Tyr Thr Leu Thr Phe Ala Glu Leu Val Glu Asp Tyr Glu His 
        195                 200                 205             


Tyr Ile Lys Glu Gly Leu Glu Lys Pro Val Glu Ile Ile Arg His Tyr 
    210                 215                 220                 


Thr Gly Pro Gly Asp Gln Thr Val Asn Pro Gln Asn Gly Phe Val Arg 
225                 230                 235                 240 


Asn Lys Val Ile Glu Gln Arg Val Pro Val Leu Ala Ser Ser Ser Gln 
                245                 250                 255     


Ser Gly Asp Ser Glu Ser Asp Ser Asp Ser Tyr Ser Ser Arg Thr Ser 
            260                 265                 270         


Ser Gln Ser Lys Gly Asn Lys Ser Tyr Leu Glu Gly Ser Ser Asp Asn 
        275                 280                 285             


Gln Leu Lys Asp Ser Glu Ser Thr Pro Val Asp Asp Arg Ile Ser Leu 
    290                 295                 300                 


Glu Gln Pro Pro Asn Gly Ser Asp Thr Pro Asn Pro Glu Lys Tyr Gln 
305                 310                 315                 320 


Glu Ser Pro Gly Ile Gln Met Lys Thr Arg Leu Lys Glu Gly Ala Ser 
                325                 330                 335     


Gln Arg Ala Lys Gln Ser Arg Arg Asn Leu Pro Arg Arg Ser Ser Phe 
            340                 345                 350         


Arg Leu Gln Thr Glu Ala Gln Glu Asp Asp Trp Tyr Asp Cys His Arg 
        355                 360                 365             


Glu Ile Arg Leu Ser Phe Ser Asp Thr Tyr Gln Asp Tyr Glu Glu Tyr 
    370                 375                 380                 


Trp Arg Ala Tyr Tyr Arg Ala Trp Gln Glu Tyr Tyr Ala Ala Ala Ser 
385                 390                 395                 400 


His Ser Tyr Tyr Trp Asn Ala Gln Arg His Pro Ser Trp Met Ala Ala 
                405                 410                 415     


Tyr His Met Asn Thr Ile Tyr Leu Gln Glu Met Met His Ser Asn Gln 
            420                 425                 430         


<210>  4089
<211>  191
<212>  PRT
<213>  Homo Sapiens

<400>  4089

Ala Ser Val Arg Ser Gly Ala Ser Asp Ala Gly Gly Glu Met Arg Glu 
1               5                   10                  15      


Gly Phe Gly Arg Gly Pro Gln Arg Glu Thr Pro Ser Pro Pro Pro Arg 
            20                  25                  30          


Glu Phe Ser Asn Leu Ser Gln Pro Arg Lys Asn Leu Trp Gly Ile Lys 
        35                  40                  45              


Ser Thr Ala Val Arg Asn Ile Asp Gly Ser Ile Asn Asn Ile Asn Glu 
    50                  55                  60                  


Asp Asp Glu Glu Asp Val Val Asp Leu Ala Ala Asn Ser Leu Leu Asn 
65                  70                  75                  80  


Lys Leu Ile His Gln Ser Leu Val Glu Ser Ser His Arg Val Glu Val 
                85                  90                  95      


Leu Gln Lys Asp Pro Ser Ser Pro Leu Tyr Ser Val Lys Thr Phe Glu 
            100                 105                 110         


Glu Leu Arg Leu Lys Glu Glu Leu Leu Lys Gly Ile Tyr Ala Met Gly 
        115                 120                 125             


Phe Asn Arg Pro Ser Lys Ile Gln Glu Met Ala Leu Pro Met Met Leu 
    130                 135                 140                 


Ala His Pro Pro Gln Asn Leu Ile Ala Gln Ser Gln Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Thr Ala Ala Phe Val Leu Ala Met Leu Ser Arg Val Asn Ala Leu 
                165                 170                 175     


Glu Leu Phe Pro Gln Cys Leu Cys Leu Ala Pro Thr Tyr Glu Leu 
            180                 185                 190     


<210>  4090
<211>  468
<212>  PRT
<213>  Homo Sapiens

<400>  4090

Ile Ala Ala Met Ala Ser Leu Leu Trp Gly Gly Asp Ala Gly Ala Ala 
1               5                   10                  15      


Glu Ser Glu Arg Leu Asn Ser His Phe Ser Asn Leu Ser Gln Pro Arg 
            20                  25                  30          


Lys Asn Leu Trp Gly Ile Lys Ser Thr Ala Val Arg Asn Ile Asp Gly 
        35                  40                  45              


Ser Ile Asn Asn Ile Asn Glu Asp Asp Glu Glu Asp Val Val Asp Leu 
    50                  55                  60                  


Ala Ala Asn Ser Leu Leu Asn Lys Leu Ile His Gln Ser Leu Val Glu 
65                  70                  75                  80  


Ser Ser His Arg Val Glu Val Leu Gln Lys Asp Pro Ser Ser Pro Leu 
                85                  90                  95      


Tyr Ser Val Lys Thr Phe Glu Glu Leu Arg Leu Lys Glu Glu Leu Leu 
            100                 105                 110         


Lys Gly Ile Tyr Ala Met Gly Phe Asn Arg Pro Ser Lys Ile Gln Glu 
        115                 120                 125             


Met Ala Leu Pro Met Met Leu Ala His Pro Pro Gln Asn Leu Ile Ala 
    130                 135                 140                 


Gln Ser Gln Ser Gly Thr Gly Lys Thr Ala Ala Phe Val Leu Ala Met 
145                 150                 155                 160 


Leu Ser Arg Val Asn Ala Leu Glu Leu Phe Pro Gln Cys Leu Cys Leu 
                165                 170                 175     


Ala Pro Thr Tyr Glu Leu Ala Leu Gln Thr Gly Arg Val Val Glu Gln 
            180                 185                 190         


Met Gly Lys Phe Cys Val Asp Val Gln Val Met Tyr Ala Ile Arg Gly 
        195                 200                 205             


Asn Arg Ile Pro Arg Gly Thr Asp Ile Thr Lys Gln Ile Ile Ile Gly 
    210                 215                 220                 


Thr Pro Gly Thr Val Leu Asp Trp Cys Phe Lys Leu Lys Leu Ile Asp 
225                 230                 235                 240 


Leu Thr Lys Ile Arg Val Phe Val Leu Asp Glu Ala Asp Val Met Ile 
                245                 250                 255     


Asp Thr Gln Gly Phe Ser Asp His Ser Ile Arg Ile Gln Arg Ala Leu 
            260                 265                 270         


Pro Ser Glu Cys Gln Met Leu Leu Phe Ser Ala Thr Phe Glu Asp Ser 
        275                 280                 285             


Val Trp His Phe Ala Glu Arg Ile Ile Pro Asp Pro Asn Val Ile Lys 
    290                 295                 300                 


Leu Arg Lys Glu Glu Leu Thr Leu Asn Asn Ile Arg Gln Tyr Tyr Val 
305                 310                 315                 320 


Leu Cys Glu His Arg Lys Asp Lys Tyr Gln Ala Leu Cys Asn Ile Tyr 
                325                 330                 335     


Gly Ser Ile Thr Ile Gly Gln Ala Ile Ile Phe Cys Gln Thr Arg Arg 
            340                 345                 350         


Asn Ala Lys Trp Leu Thr Val Glu Met Ile Gln Asp Gly His Gln Val 
        355                 360                 365             


Ser Leu Leu Ser Gly Glu Leu Thr Val Glu Gln Arg Ala Ser Ile Ile 
    370                 375                 380                 


Gln Arg Phe Arg Asp Gly Lys Glu Lys Val Leu Ile Thr Thr Asn Val 
385                 390                 395                 400 


Cys Ala Arg Gly Ile Asp Val Lys Gln Val Thr Ile Val Val Asn Phe 
                405                 410                 415     


Asp Leu Pro Val Lys Gln Gly Glu Glu Pro Asp Tyr Glu Thr Tyr Leu 
            420                 425                 430         


His Arg Ile Gly Arg Thr Gly Arg Phe Gly Lys Lys Gly Leu Ala Phe 
        435                 440                 445             


Asn Met Ile Glu Val Asp Glu Leu Pro Ser Leu Met Lys Ile Gln Asp 
    450                 455                 460                 


His Phe Ser Lys 
465             


<210>  4091
<211>  483
<212>  PRT
<213>  Homo Sapiens

<400>  4091

Met Ala Ser Leu Leu Trp Gly Gly Asp Ala Gly Ala Ala Glu Ser Glu 
1               5                   10                  15      


Arg Leu Asn Ser His Phe Ser Asn Leu Ser Gln Pro Arg Lys Asn Leu 
            20                  25                  30          


Trp Gly Ile Lys Ser Thr Ala Val Arg Asn Ile Asp Gly Ser Ile Asn 
        35                  40                  45              


Asn Ile Asn Glu Asp Asp Glu Glu Asp Val Val Asp Leu Ala Ala Asn 
    50                  55                  60                  


Ser Leu Leu Asn Lys Leu Ile His Gln Ser Leu Val Glu Ser Ser His 
65                  70                  75                  80  


Arg Val Glu Val Leu Gln Lys Asp Pro Ser Ser Pro Leu Tyr Ser Val 
                85                  90                  95      


Lys Thr Phe Glu Glu Leu Arg Leu Lys Glu Glu Leu Leu Lys Gly Ile 
            100                 105                 110         


Tyr Ala Met Gly Phe Asn Arg Pro Ser Lys Ile Gln Glu Met Ala Leu 
        115                 120                 125             


Pro Met Met Leu Ala His Pro Pro Gln Asn Leu Ile Ala Gln Ser Gln 
    130                 135                 140                 


Ser Gly Thr Gly Lys Thr Ala Ala Phe Val Leu Ala Met Leu Ser Arg 
145                 150                 155                 160 


Val Asn Ala Leu Glu Leu Phe Pro Gln Cys Leu Cys Leu Ala Pro Thr 
                165                 170                 175     


Tyr Glu Leu Ala Leu Gln Thr Gly Arg Val Val Glu Gln Met Gly Lys 
            180                 185                 190         


Phe Cys Val Asp Val Gln Val Met Tyr Ala Ile Arg Gly Asn Arg Ile 
        195                 200                 205             


Pro Arg Gly Thr Asp Ile Thr Lys Gln Ile Ile Ile Gly Thr Pro Gly 
    210                 215                 220                 


Thr Val Leu Asp Trp Cys Phe Lys Leu Lys Leu Ile Asp Leu Thr Lys 
225                 230                 235                 240 


Ile Arg Val Phe Val Leu Asp Glu Ala Asp Val Met Ile Asp Thr Gln 
                245                 250                 255     


Gly Phe Ser Asp His Ser Ile Arg Ile Gln Arg Ala Leu Pro Ser Glu 
            260                 265                 270         


Cys Gln Met Leu Leu Phe Ser Ala Thr Phe Glu Asp Ser Val Trp His 
        275                 280                 285             


Phe Ala Glu Arg Ile Ile Pro Asp Pro Asn Val Ile Lys Leu Arg Lys 
    290                 295                 300                 


Glu Glu Leu Thr Leu Asn Asn Ile Arg Gln Tyr Tyr Val Leu Cys Glu 
305                 310                 315                 320 


His Arg Lys Asp Lys Tyr Gln Ala Leu Cys Asn Ile Tyr Gly Ser Ile 
                325                 330                 335     


Thr Ile Gly Gln Ala Ile Ile Phe Cys Gln Thr Arg Arg Asn Ala Lys 
            340                 345                 350         


Trp Leu Thr Val Glu Met Ile Gln Asp Gly His Gln Val Ser Leu Leu 
        355                 360                 365             


Ser Gly Glu Leu Thr Val Glu Gln Arg Ala Ser Ile Ile Gln Arg Phe 
    370                 375                 380                 


Arg Asp Gly Lys Glu Lys Val Leu Ile Thr Thr Asn Val Cys Ala Arg 
385                 390                 395                 400 


Gly Ile Asp Val Lys Gln Val Thr Ile Val Val Asn Phe Asp Leu Pro 
                405                 410                 415     


Val Lys Gln Gly Glu Glu Pro Asp Tyr Glu Thr Tyr Leu His Arg Ile 
            420                 425                 430         


Gly Arg Thr Gly Arg Phe Gly Lys Lys Gly Leu Ala Phe Asn Met Ile 
        435                 440                 445             


Glu Val Asp Glu Leu Pro Ser Leu Met Lys Ile Gln Asp His Phe Asn 
    450                 455                 460                 


Ser Ser Ile Lys Gln Leu Asn Ala Glu Asp Met Asp Glu Ile Glu Lys 
465                 470                 475                 480 


Ile Asp Tyr 
            


<210>  4092
<211>  369
<212>  PRT
<213>  Homo Sapiens

<400>  4092

Met Gly Phe Asn Arg Pro Ser Lys Ile Gln Glu Met Ala Leu Pro Met 
1               5                   10                  15      


Met Leu Ala His Pro Pro Gln Asn Leu Ile Ala Gln Ser Gln Ser Gly 
            20                  25                  30          


Thr Gly Lys Thr Ala Ala Phe Val Leu Ala Met Leu Ser Arg Val Asn 
        35                  40                  45              


Ala Leu Glu Leu Phe Pro Gln Cys Leu Cys Leu Ala Pro Thr Tyr Glu 
    50                  55                  60                  


Leu Ala Leu Gln Thr Gly Arg Val Val Glu Gln Met Gly Lys Phe Cys 
65                  70                  75                  80  


Val Asp Val Gln Val Met Tyr Ala Ile Arg Gly Asn Arg Ile Pro Arg 
                85                  90                  95      


Gly Thr Asp Ile Thr Lys Gln Ile Ile Ile Gly Thr Pro Gly Thr Val 
            100                 105                 110         


Leu Asp Trp Cys Phe Lys Leu Lys Leu Ile Asp Leu Thr Lys Ile Arg 
        115                 120                 125             


Val Phe Val Leu Asp Glu Ala Asp Val Met Ile Asp Thr Gln Gly Phe 
    130                 135                 140                 


Ser Asp His Ser Ile Arg Ile Gln Arg Ala Leu Pro Ser Glu Cys Gln 
145                 150                 155                 160 


Met Leu Leu Phe Ser Ala Thr Phe Glu Asp Ser Val Trp His Phe Ala 
                165                 170                 175     


Glu Arg Ile Ile Pro Asp Pro Asn Val Ile Lys Leu Arg Lys Glu Glu 
            180                 185                 190         


Leu Thr Leu Asn Asn Ile Arg Gln Tyr Tyr Val Leu Cys Glu His Arg 
        195                 200                 205             


Lys Asp Lys Tyr Gln Ala Leu Cys Asn Ile Tyr Gly Ser Ile Thr Ile 
    210                 215                 220                 


Gly Gln Ala Ile Ile Phe Cys Gln Thr Arg Arg Asn Ala Lys Trp Leu 
225                 230                 235                 240 


Thr Val Glu Met Ile Gln Asp Gly His Gln Val Ser Leu Leu Ser Gly 
                245                 250                 255     


Glu Leu Thr Val Glu Gln Arg Ala Ser Ile Ile Gln Arg Phe Arg Asp 
            260                 265                 270         


Gly Lys Glu Lys Val Leu Ile Thr Thr Asn Val Cys Ala Arg Gly Ile 
        275                 280                 285             


Asp Val Lys Gln Val Thr Ile Val Val Asn Phe Asp Leu Pro Val Lys 
    290                 295                 300                 


Gln Gly Glu Glu Pro Asp Tyr Glu Thr Tyr Leu His Arg Ile Gly Arg 
305                 310                 315                 320 


Thr Gly Arg Phe Gly Lys Lys Gly Leu Ala Phe Asn Met Ile Glu Val 
                325                 330                 335     


Asp Glu Leu Pro Ser Leu Met Lys Ile Gln Asp His Phe Asn Ser Ser 
            340                 345                 350         


Ile Lys Gln Leu Asn Ala Glu Asp Met Asp Glu Ile Glu Lys Ile Asp 
        355                 360                 365             


Tyr 
    


<210>  4093
<211>  197
<212>  PRT
<213>  Homo Sapiens

<400>  4093

Met Gly Phe Asn Arg Pro Ser Lys Ile Gln Glu Met Ala Leu Pro Met 
1               5                   10                  15      


Met Leu Ala His Pro Pro Gln Asn Leu Ile Ala Gln Ser Gln Ser Gly 
            20                  25                  30          


Thr Gly Lys Thr Ala Ala Phe Val Leu Ala Met Leu Ser Arg Val Asn 
        35                  40                  45              


Ala Leu Glu Leu Phe Pro Gln Cys Leu Cys Leu Ala Pro Thr Tyr Glu 
    50                  55                  60                  


Leu Ala Leu Gln Thr Gly Arg Val Val Glu Gln Met Gly Lys Phe Cys 
65                  70                  75                  80  


Val Asp Val Gln Val Met Tyr Ala Ile Arg Gly Asn Arg Ile Pro Arg 
                85                  90                  95      


Gly Thr Asp Ile Thr Lys Gln Ile Ile Ile Gly Thr Pro Gly Thr Val 
            100                 105                 110         


Leu Asp Trp Cys Phe Lys Leu Lys Leu Ile Asp Leu Thr Lys Ile Arg 
        115                 120                 125             


Val Phe Val Leu Asp Glu Ala Asp Val Met Ile Asp Thr Gln Gly Phe 
    130                 135                 140                 


Ser Asp His Ser Ile Arg Ile Gln Arg Ile Ile Trp Leu Leu Val Ala 
145                 150                 155                 160 


Lys Glu Thr Thr Asp Asn Phe Gln Leu Pro Ser Leu Thr Leu Glu Leu 
                165                 170                 175     


Tyr Arg Asp Ile Met Glu Thr Pro His Ser Phe Leu Leu Leu Ser Gln 
            180                 185                 190         


Gly Thr Trp Arg Ile 
        195         


<210>  4094
<211>  67
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4094

Xaa Gly Ile Asp Val Lys Gln Val Thr Ile Val Val Asn Phe Asp Leu 
1               5                   10                  15      


Pro Val Lys Gln Gly Glu Glu Pro Asp Tyr Glu Thr Tyr Leu His Arg 
            20                  25                  30          


Ile Gly Arg Thr Gly Arg Phe Gly Lys Lys Gly Leu Ala Phe Asn Met 
        35                  40                  45              


Ile Glu Val Asp Glu Leu Pro Ser Leu Met Lys Ile Gln Asp His Phe 
    50                  55                  60                  


Arg Lys Ser 
65          


<210>  4095
<211>  407
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4095

Xaa Leu Val Asp Leu Ala Ala Asn Ser Leu Leu Asn Lys Leu Ile His 
1               5                   10                  15      


Gln Ser Leu Val Glu Ser Ser His Arg Val Glu Val Leu Gln Lys Asp 
            20                  25                  30          


Pro Ser Ser Pro Leu Tyr Ser Val Lys Thr Phe Glu Glu Leu Arg Leu 
        35                  40                  45              


Lys Glu Glu Leu Leu Lys Gly Ile Tyr Ala Met Gly Phe Asn Arg Pro 
    50                  55                  60                  


Ser Lys Ile Gln Glu Met Ala Leu Pro Met Met Leu Ala His Pro Pro 
65                  70                  75                  80  


Gln Asn Leu Ile Ala Gln Ser Gln Ser Gly Thr Gly Lys Thr Ala Ala 
                85                  90                  95      


Phe Val Leu Ala Met Leu Ser Arg Val Asn Ala Leu Glu Leu Phe Pro 
            100                 105                 110         


Gln Cys Leu Cys Leu Ala Pro Thr Tyr Glu Leu Ala Leu Gln Thr Gly 
        115                 120                 125             


Arg Val Val Glu Gln Met Gly Lys Phe Cys Val Asp Val Gln Val Met 
    130                 135                 140                 


Tyr Ala Ile Arg Gly Asn Arg Asn Trp Cys Phe Lys Leu Lys Leu Ile 
145                 150                 155                 160 


Asp Leu Thr Lys Ile Arg Val Phe Val Leu Asp Glu Ala Asp Val Met 
                165                 170                 175     


Ile Asp Thr Gln Gly Phe Ser Asp His Ser Ile Arg Ile Gln Arg Ala 
            180                 185                 190         


Leu Pro Ser Glu Cys Gln Met Leu Leu Phe Ser Ala Thr Phe Glu Asp 
        195                 200                 205             


Ser Val Trp His Phe Ala Glu Arg Ile Ile Pro Asp Pro Asn Val Ile 
    210                 215                 220                 


Lys Leu Arg Lys Glu Glu Leu Thr Leu Asn Asn Ile Arg Gln Tyr Tyr 
225                 230                 235                 240 


Val Leu Cys Glu His Arg Lys Asp Lys Tyr Gln Ala Leu Cys Asn Ile 
                245                 250                 255     


Tyr Gly Ser Ile Thr Ile Gly Gln Ala Ile Ile Phe Cys Gln Thr Arg 
            260                 265                 270         


Arg Asn Ala Lys Trp Leu Thr Val Glu Met Ile Gln Asp Gly His Gln 
        275                 280                 285             


Val Ser Leu Leu Ser Gly Glu Leu Thr Val Glu Gln Arg Ala Ser Ile 
    290                 295                 300                 


Ile Gln Arg Phe Arg Asp Gly Lys Glu Lys Val Leu Ile Thr Thr Asn 
305                 310                 315                 320 


Val Cys Ala Arg Gly Ile Asp Val Lys Gln Val Thr Ile Val Val Asn 
                325                 330                 335     


Phe Asp Leu Pro Val Lys Gln Gly Glu Glu Pro Asp Tyr Glu Thr Tyr 
            340                 345                 350         


Leu His Arg Ile Gly Arg Thr Gly Arg Phe Gly Lys Lys Gly Leu Ala 
        355                 360                 365             


Phe Asn Met Ile Glu Val Asp Glu Leu Pro Ser Leu Met Lys Ile Gln 
    370                 375                 380                 


Asp His Phe Asn Ser Ser Ile Lys Gln Leu Asn Ala Glu Asp Met Asp 
385                 390                 395                 400 


Glu Ile Glu Lys Ile Asp Tyr 
                405         


<210>  4096
<211>  540
<212>  PRT
<213>  Homo Sapiens

<400>  4096

Met Ala Leu Thr Arg Pro Val Arg Leu Phe Ser Leu Val Thr Arg Leu 
1               5                   10                  15      


Leu Leu Ala Pro Arg Arg Gly Leu Thr Val Arg Ser Pro Asp Glu Pro 
            20                  25                  30          


Leu Pro Val Val Arg Ile Pro Val Ala Leu Gln Arg Gln Leu Glu Gln 
        35                  40                  45              


Arg Gln Ser Arg Arg Arg Asn Leu Pro Arg Pro Val Leu Val Arg Pro 
    50                  55                  60                  


Gly Pro Leu Leu Val Ser Ala Arg Arg Pro Glu Leu Asn Gln Pro Ala 
65                  70                  75                  80  


Arg Leu Thr Leu Gly Arg Trp Glu Arg Ala Pro Leu Ala Ser Gln Gly 
                85                  90                  95      


Trp Lys Ser Arg Arg Ala Arg Arg Asp His Phe Ser Ile Glu Arg Ala 
            100                 105                 110         


Gln Gln Glu Ala Pro Ala Val Arg Lys Leu Ser Ser Lys Gly Ser Phe 
        115                 120                 125             


Ala Asp Leu Gly Leu Glu Pro Arg Val Leu His Ala Leu Gln Glu Ala 
    130                 135                 140                 


Ala Pro Glu Val Val Gln Pro Thr Thr Val Gln Ser Ser Thr Ile Pro 
145                 150                 155                 160 


Ser Leu Leu Arg Gly Arg His Val Val Cys Ala Ala Glu Thr Gly Ser 
                165                 170                 175     


Gly Lys Thr Leu Ser Tyr Leu Leu Pro Leu Leu Gln Arg Leu Leu Gly 
            180                 185                 190         


Gln Pro Ser Leu Asp Ser Leu Pro Ile Pro Ala Pro Arg Gly Leu Val 
        195                 200                 205             


Leu Val Pro Ser Arg Glu Leu Ala Gln Gln Val Arg Ala Val Ala Gln 
    210                 215                 220                 


Pro Leu Gly Arg Ser Leu Gly Leu Leu Val Arg Asp Leu Glu Gly Gly 
225                 230                 235                 240 


His Gly Met Arg Arg Ile Arg Leu Gln Leu Ser Arg Gln Pro Ser Ala 
                245                 250                 255     


Asp Val Leu Val Ala Thr Pro Gly Ala Leu Trp Lys Ala Leu Lys Ser 
            260                 265                 270         


Arg Leu Ile Ser Leu Glu Gln Leu Ser Phe Leu Val Leu Asp Glu Ala 
        275                 280                 285             


Asp Thr Leu Leu Asp Glu Ser Phe Leu Glu Leu Val Asp Tyr Ile Leu 
    290                 295                 300                 


Glu Lys Ser His Ile Ala Glu Gly Pro Ala Asp Leu Glu Asp Pro Phe 
305                 310                 315                 320 


Asn Pro Lys Ala Gln Leu Val Leu Val Gly Ala Thr Phe Pro Glu Gly 
                325                 330                 335     


Val Gly Gln Leu Leu Asn Lys Val Ala Ser Pro Asp Ala Val Thr Thr 
            340                 345                 350         


Ile Thr Ser Ser Lys Leu His Cys Ile Met Pro His Val Lys Gln Thr 
        355                 360                 365             


Phe Leu Arg Leu Lys Gly Ala Asp Lys Val Ala Glu Leu Val His Ile 
    370                 375                 380                 


Leu Lys His Arg Asp Arg Ala Glu Arg Thr Gly Pro Ser Gly Thr Val 
385                 390                 395                 400 


Leu Val Phe Cys Asn Ser Ser Ser Thr Val Asn Trp Leu Gly Tyr Ile 
                405                 410                 415     


Leu Asp Asp His Lys Ile Gln His Leu Arg Leu Gln Gly Gln Met Pro 
            420                 425                 430         


Ala Leu Met Arg Val Gly Ile Phe Gln Ser Phe Gln Lys Ser Ser Arg 
        435                 440                 445             


Asp Ile Leu Leu Cys Thr Asp Ile Ala Ser Arg Gly Leu Asp Ser Thr 
    450                 455                 460                 


Gly Val Glu Leu Val Val Asn Tyr Asp Phe Pro Pro Thr Leu Gln Asp 
465                 470                 475                 480 


Tyr Ile His Arg Ala Gly Arg Val Gly Arg Val Gly Ser Glu Val Pro 
                485                 490                 495     


Gly Thr Val Ile Ser Phe Val Thr His Pro Trp Asp Val Ser Leu Val 
            500                 505                 510         


Gln Lys Ile Glu Leu Ala Ala Arg Arg Arg Arg Ser Leu Pro Gly Leu 
        515                 520                 525             


Ala Ser Ser Val Lys Glu Pro Leu Pro Gln Ala Thr 
    530                 535                 540 


<210>  4097
<211>  565
<212>  PRT
<213>  Homo Sapiens

<400>  4097

Met Glu Asp Ser Asp Ser Ala Ala Lys Gln Leu Gly Leu Ala Glu Ala 
1               5                   10                  15      


Ala Ala Val Ala Ala Ala Ala Ala Val Ala Ala Ala Ala Ala Ala Ala 
            20                  25                  30          


Ala Gly Gly Glu Ala Glu Glu Pro Val Leu Ser Arg Asp Glu Asp Ser 
        35                  40                  45              


Glu Glu Asp Ala Asp Ser Glu Ala Glu Arg Glu Thr Pro Arg Val Thr 
    50                  55                  60                  


Ala Val Ala Val Met Ala Ala Glu Pro Gly His Met Asp Met Gly Ala 
65                  70                  75                  80  


Glu Ala Leu Pro Gly Pro Asp Glu Ala Ala Ala Ala Ala Ala Phe Ala 
                85                  90                  95      


Glu Val Thr Thr Val Thr Val Ala Asn Val Gly Ala Ala Ala Asp Asn 
            100                 105                 110         


Val Phe Thr Thr Ser Val Ala Asn Ala Ala Ser Ile Ser Gly His Val 
        115                 120                 125             


Leu Ser Gly Arg Thr Ala Leu Gln Ile Gly Asp Ser Leu Asn Thr Glu 
    130                 135                 140                 


Lys Ala Thr Leu Ile Val Val His Thr Asp Gly Ser Ile Val Glu Thr 
145                 150                 155                 160 


Thr Gly Leu Lys Gly Pro Ala Ala Pro Leu Thr Pro Gly Pro Gln Ser 
                165                 170                 175     


Pro Pro Thr Pro Leu Ala Pro Gly Gln Glu Lys Gly Gly Thr Lys Tyr 
            180                 185                 190         


Asn Trp Asp Pro Ser Val Tyr Asp Ser Glu Leu Pro Val Arg Cys Arg 
        195                 200                 205             


Asn Ile Ser Gly Thr Leu Tyr Lys Asn Arg Leu Gly Ser Gly Gly Arg 
    210                 215                 220                 


Gly Arg Cys Ile Lys Gln Gly Glu Asn Trp Tyr Ser Pro Thr Glu Phe 
225                 230                 235                 240 


Glu Ala Met Ala Gly Arg Ala Ser Ser Lys Asp Trp Lys Arg Ser Ile 
                245                 250                 255     


Arg Tyr Ala Gly Arg Pro Leu Gln Cys Leu Ile Gln Asp Gly Ile Leu 
            260                 265                 270         


Asn Pro His Ala Ala Ser Cys Thr Cys Ala Ala Cys Cys Asp Asp Met 
        275                 280                 285             


Thr Leu Ser Gly Pro Val Arg Leu Phe Val Pro Tyr Lys Arg Arg Lys 
    290                 295                 300                 


Lys Glu Asn Glu Leu Pro Thr Thr Pro Val Lys Lys Asp Ser Pro Lys 
305                 310                 315                 320 


Asn Ile Thr Leu Leu Pro Ala Thr Ala Ala Thr Thr Phe Thr Val Thr 
                325                 330                 335     


Pro Ser Gly Gln Ile Thr Thr Ser Gly Ala Leu Thr Phe Asp Arg Ala 
            340                 345                 350         


Ser Thr Val Glu Ala Thr Ala Val Ile Ser Glu Ser Pro Ala Gln Gly 
        355                 360                 365             


Asp Val Phe Ala Gly Ala Thr Val Gln Glu Ala Ser Val Gln Pro Pro 
    370                 375                 380                 


Cys Arg Ala Ser His Pro Glu Pro His Tyr Pro Gly Tyr Gln Asp Ser 
385                 390                 395                 400 


Cys Gln Ile Ala Pro Phe Pro Glu Ala Ala Leu Pro Thr Ser His Pro 
                405                 410                 415     


Lys Ile Val Leu Thr Ser Leu Pro Ala Leu Ala Val Pro Pro Pro Thr 
            420                 425                 430         


Pro Thr Lys Ala Ala Pro Pro Ala Leu Val Asn Gly Leu Glu Leu Ser 
        435                 440                 445             


Glu Pro Arg Ser Trp Leu Tyr Leu Glu Glu Met Val Asn Ser Leu Leu 
    450                 455                 460                 


Asn Thr Ala Gln Gln Leu Lys Thr Leu Phe Glu Gln Ala Lys His Ala 
465                 470                 475                 480 


Ser Thr Tyr Arg Glu Ala Ala Thr Asn Gln Ala Lys Ile His Ala Asp 
                485                 490                 495     


Ala Glu Arg Lys Glu Gln Ser Cys Val Asn Cys Gly Arg Glu Ala Met 
            500                 505                 510         


Ser Glu Cys Thr Gly Cys His Lys Val Asn Tyr Cys Ser Thr Phe Cys 
        515                 520                 525             


Gln Arg Lys Asp Trp Lys Asp His Gln His Ile Cys Gly Gln Ser Ala 
    530                 535                 540                 


Ala Val Thr Val Gln Ala Asp Glu Val His Val Ala Glu Ser Val Met 
545                 550                 555                 560 


Glu Lys Val Thr Val 
                565 


<210>  4098
<211>  349
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4098

Xaa Leu Tyr Lys Asn Arg Leu Gly Ser Gly Gly Arg Gly Arg Cys Ile 
1               5                   10                  15      


Lys Gln Gly Glu Asn Trp Tyr Ser Pro Thr Glu Phe Glu Ala Met Ala 
            20                  25                  30          


Gly Arg Ala Ser Ser Lys Asp Trp Lys Arg Ser Ile Arg Tyr Ala Gly 
        35                  40                  45              


Arg Pro Leu Gln Cys Leu Ile Gln Asp Gly Ile Leu Asn Pro His Ala 
    50                  55                  60                  


Ala Ser Cys Thr Cys Ala Ala Cys Cys Asp Asp Met Thr Leu Ser Gly 
65                  70                  75                  80  


Pro Val Arg Leu Phe Val Pro Tyr Lys Arg Arg Lys Lys Glu Asn Glu 
                85                  90                  95      


Leu Pro Thr Thr Pro Val Lys Lys Asp Ser Pro Lys Asn Ile Thr Leu 
            100                 105                 110         


Leu Pro Ala Thr Ala Ala Thr Thr Phe Thr Val Thr Pro Ser Gly Gln 
        115                 120                 125             


Ile Thr Thr Ser Gly Ala Leu Thr Phe Asp Arg Ala Ser Thr Val Glu 
    130                 135                 140                 


Ala Thr Ala Val Ile Ser Glu Ser Pro Ala Gln Gly Asp Val Phe Ala 
145                 150                 155                 160 


Gly Ala Thr Val Gln Glu Ala Ser Val Gln Pro Pro Cys Arg Ala Ser 
                165                 170                 175     


His Pro Glu Pro His Tyr Pro Gly Tyr Gln Asp Ser Cys Gln Ile Ala 
            180                 185                 190         


Pro Phe Pro Glu Ala Ala Leu Pro Thr Ser His Pro Lys Ile Val Leu 
        195                 200                 205             


Thr Ser Leu Pro Ala Leu Ala Val Pro Pro Pro Thr Pro Thr Lys Ala 
    210                 215                 220                 


Ala Pro Pro Ala Leu Val Asn Gly Leu Glu Leu Ser Glu Pro Arg Ser 
225                 230                 235                 240 


Trp Leu Tyr Leu Glu Glu Met Val Asn Ser Leu Leu Asn Thr Ala Gln 
                245                 250                 255     


Gln Leu Lys Thr Leu Phe Glu Gln Ala Lys His Ala Ser Thr Tyr Arg 
            260                 265                 270         


Glu Ala Ala Thr Asn Gln Ala Lys Ile His Ala Asp Ala Glu Arg Lys 
        275                 280                 285             


Glu Gln Ser Cys Val Asn Cys Gly Arg Glu Ala Met Ser Glu Cys Thr 
    290                 295                 300                 


Gly Cys His Lys Val Asn Tyr Cys Ser Thr Phe Cys Gln Arg Lys Arg 
305                 310                 315                 320 


Trp Ser Leu Thr Met Leu Thr Ser Leu Val Ser Ile Ser Trp Leu Arg 
                325                 330                 335     


Ala Ile Leu Pro Cys Gln Pro Pro Lys Val Leu Gly Leu 
            340                 345                 


<210>  4099
<211>  86
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4099

Xaa Pro Val Leu Ser Arg Asp Glu Asp Ser Glu Glu Asp Ala Asp Ser 
1               5                   10                  15      


Glu Ala Glu Arg Glu Thr Pro Arg Val Thr Ala Val Ala Val Met Ala 
            20                  25                  30          


Ala Glu Pro Gly His Met Asp Met Gly Ala Glu Ala Leu Pro Gly Pro 
        35                  40                  45              


Asp Glu Ala Ala Ala Ala Ala Ala Phe Ala Gly Lys Cys Ala Arg Arg 
    50                  55                  60                  


Pro Leu Ala Ser Ser Gly Ser Arg Ala Pro Thr Pro Arg Ala Cys Pro 
65                  70                  75                  80  


Ala Gln Leu Ser Gln Arg 
                85      


<210>  4100
<211>  136
<212>  PRT
<213>  Homo Sapiens

<400>  4100

Met Ala Ile Leu Ser Leu Arg Ala Pro Gly Pro Trp Gln Ala Met Gln 
1               5                   10                  15      


Ala His Leu Asn Pro Phe Asn Lys Gln Ser Gly Pro Arg Gln His Glu 
            20                  25                  30          


Gln Gly Pro Gly Glu Glu Val Pro Asp Val Thr Pro Glu Glu Ala Leu 
        35                  40                  45              


Pro Glu Leu Pro Pro Gly Glu Pro Glu Phe Arg Cys Pro Glu Arg Val 
    50                  55                  60                  


Met Asp Leu Gly Leu Ser Glu Asp His Phe Ser Arg Pro Val Gly Leu 
65                  70                  75                  80  


Phe Leu Ala Ser Asp Val Gln Gln Leu Arg Gln Ala Ile Glu Glu Cys 
                85                  90                  95      


Lys Gln Val Ile Leu Glu Leu Pro Glu Gln Ser Glu Lys Gln Lys Asp 
            100                 105                 110         


Ala Val Val Arg Leu Ile His Leu Arg Leu Lys Leu Gln Glu Leu Lys 
        115                 120                 125             


Asp Pro Asn Glu Asp Glu Pro Asn 
    130                 135     


<210>  4101
<211>  512
<212>  PRT
<213>  Homo Sapiens

<400>  4101

Met Ala Ile Leu Ser Leu Arg Ala Pro Gly Pro Trp Gln Ala Met Gln 
1               5                   10                  15      


Val Trp Ala Asp Arg Thr Leu Leu Thr Pro His Thr Gly Val Thr Ser 
            20                  25                  30          


Gln Val Leu Gly Val Ala Ala Ala Val Met Thr Pro Leu Pro Gly Gly 
        35                  40                  45              


His Ala Ala Gly Arg Thr Arg Glu Ala Arg Trp Asp Ala Met Glu Tyr 
    50                  55                  60                  


Asp Glu Lys Leu Ala Arg Phe Arg Gln Ala His Leu Asn Pro Phe Asn 
65                  70                  75                  80  


Lys Gln Ser Gly Pro Arg Gln His Glu Gln Gly Pro Gly Glu Glu Val 
                85                  90                  95      


Pro Asp Val Thr Pro Glu Glu Ala Leu Pro Glu Leu Pro Pro Gly Glu 
            100                 105                 110         


Pro Glu Phe Arg Cys Pro Glu Arg Val Met Asp Leu Gly Leu Ser Glu 
        115                 120                 125             


Asp His Phe Ser Arg Pro Val Gly Leu Phe Leu Ala Ser Asp Val Gln 
    130                 135                 140                 


Gln Leu Arg Gln Ala Ile Glu Glu Cys Lys Gln Val Ile Leu Glu Leu 
145                 150                 155                 160 


Pro Glu Gln Ser Glu Lys Gln Lys Asp Ala Val Val Arg Leu Ile His 
                165                 170                 175     


Leu Arg Leu Lys Leu Gln Glu Leu Lys Asp Pro Asn Glu Asp Glu Pro 
            180                 185                 190         


Asn Ile Arg Val Leu Leu Glu His Arg Phe Tyr Lys Glu Lys Ser Lys 
        195                 200                 205             


Ser Val Lys Gln Thr Cys Asp Lys Cys Asn Thr Ile Ile Trp Gly Leu 
    210                 215                 220                 


Ile Gln Thr Trp Tyr Thr Cys Thr Gly Cys Tyr Tyr Arg Cys His Ser 
225                 230                 235                 240 


Lys Cys Leu Asn Leu Ile Ser Lys Pro Cys Val Ser Ser Lys Val Ser 
                245                 250                 255     


His Gln Ala Glu Tyr Glu Leu Asn Ile Cys Pro Glu Thr Gly Leu Asp 
            260                 265                 270         


Ser Gln Asp Tyr Arg Cys Ala Glu Cys Arg Ala Pro Ile Ser Leu Arg 
        275                 280                 285             


Gly Val Pro Ser Glu Ala Arg Gln Cys Asp Tyr Thr Gly Gln Tyr Tyr 
    290                 295                 300                 


Cys Ser His Cys His Trp Asn Asp Leu Ala Val Ile Pro Ala Arg Val 
305                 310                 315                 320 


Val His Asn Trp Asp Phe Glu Pro Arg Lys Val Ser Arg Cys Ser Met 
                325                 330                 335     


Arg Tyr Leu Ala Leu Met Val Ser Arg Pro Val Leu Arg Leu Arg Glu 
            340                 345                 350         


Ile Asn Pro Leu Leu Phe Ser Tyr Val Glu Glu Leu Val Glu Ile Arg 
        355                 360                 365             


Lys Leu Arg Gln Asp Ile Leu Leu Met Lys Pro Tyr Phe Ile Thr Cys 
    370                 375                 380                 


Arg Glu Ala Met Glu Ala Arg Leu Leu Leu Gln Leu Gln Asp Arg Gln 
385                 390                 395                 400 


His Phe Val Glu Asn Asp Glu Met Tyr Ser Val Gln Asp Leu Leu Asp 
                405                 410                 415     


Val His Ala Gly Arg Leu Gly Cys Ser Leu Thr Glu Ile His Thr Leu 
            420                 425                 430         


Phe Ala Lys His Ile Lys Leu Asp Cys Glu Arg Cys Gln Ala Lys Gly 
        435                 440                 445             


Phe Val Cys Glu Leu Cys Arg Glu Gly Asp Val Leu Phe Pro Phe Asp 
    450                 455                 460                 


Ser His Thr Ser Val Cys Ala Asp Cys Ser Ala Val Phe His Arg Asp 
465                 470                 475                 480 


Cys Tyr Tyr Asp Asn Ser Thr Thr Cys Pro Lys Cys Ala Arg Leu Ser 
                485                 490                 495     


Leu Arg Lys Gln Ser Leu Phe Gln Glu Pro Gly Pro Asp Val Glu Ala 
            500                 505                 510         


<210>  4102
<211>  125
<212>  PRT
<213>  Homo Sapiens

<400>  4102

Met Asp Leu Gly Leu Ser Glu Asp His Phe Ser Arg Pro Val Gly Leu 
1               5                   10                  15      


Phe Leu Ala Ser Asp Val Gln Gln Leu Arg Gln Ala Ile Glu Glu Cys 
            20                  25                  30          


Lys Gln Val Ile Leu Glu Leu Pro Glu Gln Ser Glu Lys Gln Lys Asp 
        35                  40                  45              


Ala Val Val Arg Leu Ile His Leu Arg Leu Lys Leu Gln Glu Leu Lys 
    50                  55                  60                  


Asp Pro Asn Glu Asp Glu Pro Asn Ile Arg Val Leu Leu Glu His Arg 
65                  70                  75                  80  


Phe Tyr Lys Glu Lys Ser Lys Ser Val Lys Gln Thr Cys Asp Lys Cys 
                85                  90                  95      


Asn Thr Ile Ile Trp Gly Leu Ile Gln Thr Trp Tyr Thr Cys Thr Gly 
            100                 105                 110         


Cys Tyr Tyr Arg Cys His Ser Lys Cys Leu Asn Leu Ile 
        115                 120                 125 


<210>  4103
<211>  391
<212>  PRT
<213>  Homo Sapiens

<400>  4103

Met Asp Leu Gly Leu Ser Glu Asp His Phe Ser Arg Pro Val Gly Leu 
1               5                   10                  15      


Phe Leu Ala Ser Asp Val Gln Gln Leu Arg Gln Ala Ile Glu Glu Cys 
            20                  25                  30          


Lys Gln Val Ile Leu Glu Leu Pro Glu Gln Ser Glu Lys Gln Lys Asp 
        35                  40                  45              


Ala Val Val Arg Leu Ile His Leu Arg Leu Lys Leu Gln Glu Leu Lys 
    50                  55                  60                  


Asp Pro Asn Glu Asp Glu Pro Asn Ile Arg Val Leu Leu Glu His Arg 
65                  70                  75                  80  


Phe Tyr Lys Glu Lys Ser Lys Ser Val Lys Gln Thr Cys Asp Lys Cys 
                85                  90                  95      


Asn Thr Ile Ile Trp Gly Leu Ile Gln Thr Trp Tyr Thr Cys Thr Gly 
            100                 105                 110         


Cys Tyr Tyr Arg Cys His Ser Lys Cys Leu Asn Leu Ile Ser Lys Pro 
        115                 120                 125             


Cys Val Ser Ser Lys Val Ser His Gln Ala Glu Tyr Glu Leu Asn Ile 
    130                 135                 140                 


Cys Pro Glu Thr Gly Leu Asp Ser Gln Asp Tyr Arg Cys Ala Glu Cys 
145                 150                 155                 160 


Arg Ala Pro Ile Ser Leu Arg Gly Val Pro Ser Glu Ala Arg Gln Cys 
                165                 170                 175     


Asp Tyr Thr Gly Gln Tyr Tyr Cys Ser His Cys His Trp Asn Asp Leu 
            180                 185                 190         


Ala Val Ile Pro Ala Arg Val Val His Asn Trp Asp Phe Glu Pro Arg 
        195                 200                 205             


Lys Val Ser Arg Cys Ser Met Arg Tyr Leu Ala Leu Met Val Ser Arg 
    210                 215                 220                 


Pro Val Leu Arg Leu Arg Glu Ile Asn Pro Leu Leu Phe Ser Tyr Val 
225                 230                 235                 240 


Glu Glu Leu Val Glu Ile Arg Lys Leu Arg Gln Asp Ile Leu Leu Met 
                245                 250                 255     


Lys Pro Tyr Phe Ile Thr Cys Arg Glu Ala Met Glu Ala Arg Leu Leu 
            260                 265                 270         


Leu Gln Leu Gln Asp Arg Gln His Phe Val Glu Asn Asp Glu Met Tyr 
        275                 280                 285             


Ser Val Gln Asp Leu Leu Asp Val His Ala Gly Arg Leu Gly Cys Ser 
    290                 295                 300                 


Leu Thr Glu Ile His Thr Leu Phe Ala Lys His Ile Lys Leu Asp Cys 
305                 310                 315                 320 


Glu Arg Cys Gln Ala Lys Gly Phe Val Cys Glu Leu Cys Arg Glu Gly 
                325                 330                 335     


Asp Val Leu Phe Pro Phe Asp Ser His Thr Ser Val Cys Ala Asp Cys 
            340                 345                 350         


Ser Ala Val Phe His Arg Asp Cys Tyr Tyr Asp Asn Ser Thr Thr Cys 
        355                 360                 365             


Pro Lys Cys Ala Arg Leu Ser Leu Arg Lys Gln Ser Leu Phe Gln Glu 
    370                 375                 380                 


Pro Gly Pro Asp Val Glu Ala 
385                 390     


<210>  4104
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  4104

Met Glu Tyr Asp Glu Lys Leu Ala Arg Phe Arg Gln Ala His Leu Asn 
1               5                   10                  15      


Pro Phe Asn Lys Gln Ser Gly Pro Arg Gln His Glu Gln Gly Pro Gly 
            20                  25                  30          


Glu Glu Val Pro Asp Val Thr Pro Glu Glu Ala Leu Pro Glu Leu Pro 
        35                  40                  45              


Pro Gly Glu Pro Glu Phe Arg Cys Pro Glu Arg Val Met Asp Leu Gly 
    50                  55                  60                  


Leu Ser 
65      


<210>  4105
<211>  107
<212>  PRT
<213>  Homo Sapiens

<400>  4105

Met Glu Tyr Asp Glu Lys Leu Ala Arg Phe Arg Gln Ala His Leu Asn 
1               5                   10                  15      


Pro Phe Asn Lys Gln Ser Gly Pro Arg Gln His Glu Gln Gly Pro Gly 
            20                  25                  30          


Glu Glu Val Pro Asp Val Thr Pro Glu Glu Ala Leu Pro Glu Leu Pro 
        35                  40                  45              


Pro Gly Glu Pro Glu Phe Arg Cys Pro Glu Arg Val Met Asp Leu Gly 
    50                  55                  60                  


Leu Ser Glu Asp His Phe Ser Arg Pro Val Asp Gly Pro Leu Thr Ala 
65                  70                  75                  80  


Pro Ala Pro Asn Leu Gly Arg Val Cys Ser Trp Pro Leu Thr Ser Ser 
                85                  90                  95      


Ser Cys Gly Arg Arg Ser Arg Ser Ala Ser Arg 
            100                 105         


<210>  4106
<211>  106
<212>  PRT
<213>  Homo Sapiens

<400>  4106

Met Glu Tyr Asp Glu Lys Leu Ala Arg Phe Arg Gln Ala His Leu Asn 
1               5                   10                  15      


Pro Phe Asn Lys Gln Ser Gly Pro Arg Gln His Glu Gln Gly Pro Gly 
            20                  25                  30          


Glu Glu Val Pro Asp Val Thr Pro Glu Glu Ala Leu Pro Glu Leu Pro 
        35                  40                  45              


Pro Gly Glu Pro Glu Phe Arg Cys Pro Glu Arg Val Met Asp Leu Gly 
    50                  55                  60                  


Leu Ser Glu Asp His Phe Ser Arg Pro Val Gly Leu Phe Leu Ala Ser 
65                  70                  75                  80  


Asp Val Gln Gln Leu Arg Gln Ala Ile Glu Glu Cys Lys Gln Val Ile 
                85                  90                  95      


Leu Glu Leu Pro Glu Gln Ser Glu Lys Gln 
            100                 105     


<210>  4107
<211>  134
<212>  PRT
<213>  Homo Sapiens

<400>  4107

Met Glu Tyr Asp Glu Lys Leu Ala Arg Phe Arg Gln Ala His Leu Asn 
1               5                   10                  15      


Pro Phe Asn Lys Gln Ser Gly Pro Arg Gln His Glu Gln Gly Pro Gly 
            20                  25                  30          


Glu Glu Val Pro Asp Val Thr Pro Glu Glu Ala Leu Pro Glu Leu Pro 
        35                  40                  45              


Pro Gly Glu Pro Glu Phe Arg Cys Pro Glu Arg Val Met Asp Leu Gly 
    50                  55                  60                  


Leu Ser Glu Asp His Phe Ser Arg Pro Val Gly Leu Phe Leu Ala Ser 
65                  70                  75                  80  


Asp Val Gln Gln Leu Arg Gln Ala Ile Glu Glu Cys Lys Gln Val Ile 
                85                  90                  95      


Leu Glu Leu Pro Glu Gln Ser Glu Lys Gln Lys Asp Ala Val Val Arg 
            100                 105                 110         


Leu Ile His Leu Arg Leu Lys Leu Gln Glu Leu Lys Asp Pro Asn Glu 
        115                 120                 125             


Asp Glu Pro Asn Ile Arg 
    130                 


<210>  4108
<211>  150
<212>  PRT
<213>  Homo Sapiens

<400>  4108

Met Glu Tyr Asp Glu Lys Leu Ala Arg Phe Arg Gln Ala His Leu Asn 
1               5                   10                  15      


Pro Phe Asn Lys Gln Ser Gly Pro Arg Gln His Glu Gln Gly Pro Gly 
            20                  25                  30          


Glu Glu Val Pro Asp Val Thr Pro Glu Glu Ala Leu Pro Glu Leu Pro 
        35                  40                  45              


Pro Gly Glu Pro Glu Phe Arg Cys Pro Glu Arg Val Met Asp Leu Gly 
    50                  55                  60                  


Leu Ser Glu Asp His Phe Ser Arg Pro Val Gly Leu Phe Leu Ala Ser 
65                  70                  75                  80  


Asp Val Gln Gln Leu Arg Gln Ala Ile Glu Glu Cys Lys Gln Val Ile 
                85                  90                  95      


Leu Glu Leu Pro Glu Gln Ser Glu Lys Gln Lys Asp Ala Val Val Arg 
            100                 105                 110         


Leu Ile His Leu Arg Leu Lys Leu Gln Glu Leu Lys Asp Pro Asn Glu 
        115                 120                 125             


Asp Glu Pro Asn Ile Arg Val Leu Leu Glu His Arg Phe Tyr Lys Glu 
    130                 135                 140                 


Lys Ser Lys Ser Val Lys 
145                 150 


<210>  4109
<211>  451
<212>  PRT
<213>  Homo Sapiens

<400>  4109

Met Glu Tyr Asp Glu Lys Leu Ala Arg Phe Arg Gln Ala His Leu Asn 
1               5                   10                  15      


Pro Phe Asn Lys Gln Ser Gly Pro Arg Gln His Glu Gln Gly Pro Gly 
            20                  25                  30          


Glu Glu Val Pro Asp Val Thr Pro Glu Glu Ala Leu Pro Glu Leu Pro 
        35                  40                  45              


Pro Gly Glu Pro Glu Phe Arg Cys Pro Glu Arg Val Met Asp Leu Gly 
    50                  55                  60                  


Leu Ser Glu Asp His Phe Ser Arg Pro Val Gly Leu Phe Leu Ala Ser 
65                  70                  75                  80  


Asp Val Gln Gln Leu Arg Gln Ala Ile Glu Glu Cys Lys Gln Val Ile 
                85                  90                  95      


Leu Glu Leu Pro Glu Gln Ser Glu Lys Gln Lys Asp Ala Val Val Arg 
            100                 105                 110         


Leu Ile His Leu Arg Leu Lys Leu Gln Glu Leu Lys Asp Pro Asn Glu 
        115                 120                 125             


Asp Glu Pro Asn Ile Arg Val Leu Leu Glu His Arg Phe Tyr Lys Glu 
    130                 135                 140                 


Lys Ser Lys Ser Val Lys Gln Thr Cys Asp Lys Cys Asn Thr Ile Ile 
145                 150                 155                 160 


Trp Gly Leu Ile Gln Thr Trp Tyr Thr Cys Thr Gly Cys Tyr Tyr Arg 
                165                 170                 175     


Cys His Ser Lys Cys Leu Asn Leu Ile Ser Lys Pro Cys Val Ser Ser 
            180                 185                 190         


Lys Val Ser His Gln Ala Glu Tyr Glu Leu Asn Ile Cys Pro Glu Thr 
        195                 200                 205             


Gly Leu Asp Ser Gln Asp Tyr Arg Cys Ala Glu Cys Arg Ala Pro Ile 
    210                 215                 220                 


Ser Leu Arg Gly Val Pro Ser Glu Ala Arg Gln Cys Asp Tyr Thr Gly 
225                 230                 235                 240 


Gln Tyr Tyr Cys Ser His Cys His Trp Asn Asp Leu Ala Val Ile Pro 
                245                 250                 255     


Ala Arg Val Val His Asn Trp Asp Phe Glu Pro Arg Lys Val Ser Arg 
            260                 265                 270         


Cys Ser Met Arg Tyr Leu Ala Leu Met Val Ser Arg Pro Val Leu Arg 
        275                 280                 285             


Leu Arg Glu Ile Asn Pro Leu Leu Phe Ser Tyr Val Glu Glu Leu Val 
    290                 295                 300                 


Glu Ile Arg Lys Leu Arg Gln Asp Ile Leu Leu Met Lys Pro Tyr Phe 
305                 310                 315                 320 


Ile Thr Cys Arg Glu Ala Met Glu Ala Arg Leu Leu Leu Gln Leu Gln 
                325                 330                 335     


Asp Arg Gln His Phe Val Glu Asn Asp Glu Met Tyr Ser Val Gln Asp 
            340                 345                 350         


Leu Leu Asp Val His Ala Gly Arg Leu Gly Cys Ser Leu Thr Glu Ile 
        355                 360                 365             


His Thr Leu Phe Ala Lys His Ile Lys Leu Asp Cys Glu Arg Cys Gln 
    370                 375                 380                 


Ala Lys Gly Phe Val Cys Glu Leu Cys Arg Glu Gly Asp Val Leu Phe 
385                 390                 395                 400 


Pro Phe Asp Ser His Thr Ser Val Cys Ala Asp Cys Ser Ala Val Phe 
                405                 410                 415     


His Arg Asp Cys Tyr Tyr Asp Asn Ser Thr Thr Cys Pro Lys Cys Ala 
            420                 425                 430         


Arg Leu Ser Leu Arg Lys Gln Ser Leu Phe Gln Glu Pro Gly Pro Asp 
        435                 440                 445             


Val Glu Ala 
    450     


<210>  4110
<211>  451
<212>  PRT
<213>  Homo Sapiens

<400>  4110

Met Glu Tyr Asp Glu Lys Leu Ala Arg Phe Arg Gln Ala His Leu Asn 
1               5                   10                  15      


Pro Phe Asn Lys Gln Ser Gly Pro Arg Gln His Glu Gln Gly Pro Gly 
            20                  25                  30          


Glu Glu Val Pro Asp Val Thr Pro Glu Glu Ala Leu Pro Glu Leu Pro 
        35                  40                  45              


Pro Gly Glu Pro Glu Phe Arg Cys Pro Glu Arg Val Met Asp Leu Gly 
    50                  55                  60                  


Leu Ser Glu Asp His Phe Ser Arg Pro Val Gly Leu Phe Leu Ala Ser 
65                  70                  75                  80  


Asp Val Gln Gln Leu Arg Gln Ala Ile Glu Glu Cys Lys Gln Val Ile 
                85                  90                  95      


Leu Glu Leu Pro Glu Gln Ser Glu Lys Gln Lys Asp Ala Val Val Arg 
            100                 105                 110         


Leu Ile His Leu Arg Leu Lys Leu Gln Glu Leu Lys Asp Pro Asn Glu 
        115                 120                 125             


Asp Glu Pro Asn Ile Arg Val Leu Leu Glu His Arg Phe Tyr Lys Glu 
    130                 135                 140                 


Lys Ser Lys Ser Val Lys Gln Thr Cys Asp Lys Cys Asn Thr Ile Ile 
145                 150                 155                 160 


Trp Gly Leu Ile Gln Thr Trp Tyr Thr Cys Thr Gly Cys Tyr Tyr Arg 
                165                 170                 175     


Cys His Ser Lys Cys Leu Asn Leu Ile Ser Lys Pro Cys Val Ser Ser 
            180                 185                 190         


Lys Val Ser His Gln Ala Glu Tyr Glu Leu Asn Ile Cys Pro Glu Thr 
        195                 200                 205             


Gly Leu Asp Ser Gln Asp Tyr Arg Cys Ala Glu Cys Arg Ala Pro Ile 
    210                 215                 220                 


Ser Leu Arg Gly Val Pro Ser Glu Ala Arg Gln Cys Asp Tyr Thr Gly 
225                 230                 235                 240 


Gln Tyr Tyr Cys Ser His Cys His Trp Asn Asp Leu Ala Val Ile Pro 
                245                 250                 255     


Ala Arg Val Val His Asn Trp Asp Phe Glu Pro Arg Lys Val Ser Arg 
            260                 265                 270         


Cys Ser Met Arg Tyr Leu Ala Leu Met Val Ser Arg Pro Val Leu Arg 
        275                 280                 285             


Leu Arg Glu Ile Asn Pro Leu Leu Phe Ser Tyr Val Glu Glu Leu Val 
    290                 295                 300                 


Glu Ile Arg Lys Leu Arg Gln Asp Ile Leu Leu Met Lys Pro Tyr Phe 
305                 310                 315                 320 


Ile Thr Cys Arg Glu Ala Met Glu Ala Arg Leu Leu Leu Gln Leu Gln 
                325                 330                 335     


Asp Arg Gln His Phe Val Glu Asn Asp Glu Met Tyr Ser Val Gln Asp 
            340                 345                 350         


Leu Leu Asp Val His Ala Gly Arg Leu Gly Cys Ser Leu Thr Glu Ile 
        355                 360                 365             


His Thr Leu Phe Ala Lys His Ile Lys Leu Asp Cys Glu Arg Cys Gln 
    370                 375                 380                 


Ala Lys Gly Phe Val Cys Glu Leu Cys Arg Glu Gly Asp Val Leu Phe 
385                 390                 395                 400 


Pro Phe Asp Ser His Thr Ser Val Cys Ala Asp Cys Ser Ala Val Phe 
                405                 410                 415     


His Arg Asp Cys Tyr Tyr Asp Asn Ser Thr Thr Cys Pro Lys Cys Ala 
            420                 425                 430         


Arg Leu Ser Leu Arg Lys Gln Ser Leu Phe Gln Glu Pro Gly Pro Asp 
        435                 440                 445             


Val Glu Ala 
    450     


<210>  4111
<211>  434
<212>  PRT
<213>  Homo Sapiens

<400>  4111

Met Glu Tyr Asp Glu Lys Leu Ala Arg Phe Arg Gln Ala His Leu Asn 
1               5                   10                  15      


Pro Phe Asn Lys Gln Ser Gly Pro Arg Gln His Glu Gln Gly Pro Gly 
            20                  25                  30          


Glu Glu Val Pro Asp Val Thr Pro Glu Glu Ala Leu Pro Glu Leu Pro 
        35                  40                  45              


Pro Gly Glu Pro Glu Phe Arg Cys Pro Glu Arg Val Met Asp Leu Gly 
    50                  55                  60                  


Leu Ser Glu Asp His Phe Ser Arg Pro Val Gly Leu Phe Leu Ala Ser 
65                  70                  75                  80  


Asp Val Gln Gln Leu Arg Gln Ala Ile Glu Glu Cys Lys Gln Val Ile 
                85                  90                  95      


Leu Glu Leu Pro Glu Gln Ser Glu Lys Gln Lys Asp Ala Val Val Arg 
            100                 105                 110         


Leu Ile His Leu Arg Leu Lys Leu Gln Glu Leu Lys Asp Pro Asn Glu 
        115                 120                 125             


Asp Glu Pro Asn Ile Arg Val Leu Leu Glu His Arg Phe Tyr Lys Glu 
    130                 135                 140                 


Lys Ser Lys Ser Val Lys Gln Thr Cys Asp Lys Cys Asn Thr Ile Ile 
145                 150                 155                 160 


Trp Gly Leu Ile Gln Thr Trp Tyr Thr Cys Thr Gly Cys Tyr Tyr Arg 
                165                 170                 175     


Cys His Ser Lys Cys Leu Asn Leu Ile Ser Lys Pro Cys Val Ser Ser 
            180                 185                 190         


Lys Val Ser His Gln Ala Glu Tyr Glu Leu Asn Ile Cys Pro Glu Thr 
        195                 200                 205             


Gly Leu Asp Ser Gln Asp Tyr Arg Cys Ala Glu Cys Arg Ala Pro Ile 
    210                 215                 220                 


Ser Leu Arg Gly Val Pro Ser Glu Ala Arg Gln Cys Asp Tyr Thr Gly 
225                 230                 235                 240 


Gln Tyr Tyr Cys Ser His Cys His Trp Asn Asp Leu Ala Val Ile Pro 
                245                 250                 255     


Ala Arg Val Val His Asn Trp Asp Phe Glu Pro Arg Lys Val Ser Arg 
            260                 265                 270         


Cys Ser Met Arg Tyr Leu Ala Leu Met Val Ser Arg Pro Val Leu Arg 
        275                 280                 285             


Leu Arg Glu Ile Asn Pro Leu Leu Phe Ser Tyr Val Glu Glu Leu Val 
    290                 295                 300                 


Glu Ile Arg Lys Leu Arg Gln Asp Ile Leu Leu Met Lys Pro Tyr Phe 
305                 310                 315                 320 


Ile Thr Cys Arg Glu Ala Met Glu Ala Arg Leu Leu Leu Gln Asp Leu 
                325                 330                 335     


Leu Asp Val His Ala Gly Arg Leu Gly Cys Ser Leu Thr Glu Ile His 
            340                 345                 350         


Thr Leu Phe Ala Lys His Ile Lys Leu Asp Cys Glu Arg Cys Gln Ala 
        355                 360                 365             


Lys Gly Phe Val Cys Glu Leu Cys Arg Glu Gly Asp Val Leu Phe Pro 
    370                 375                 380                 


Phe Asp Ser His Thr Ser Val Cys Ala Asp Cys Ser Ala Val Phe His 
385                 390                 395                 400 


Arg Asp Cys Tyr Tyr Asp Asn Ser Thr Thr Cys Pro Lys Cys Ala Arg 
                405                 410                 415     


Leu Ser Leu Arg Lys Gln Ser Leu Phe Gln Glu Pro Gly Pro Asp Val 
            420                 425                 430         


Glu Ala 
        


<210>  4112
<211>  451
<212>  PRT
<213>  Homo Sapiens

<400>  4112

Met Glu Tyr Asp Glu Lys Leu Ala Arg Phe Arg Gln Ala His Leu Asn 
1               5                   10                  15      


Pro Phe Asn Lys Gln Ser Gly Pro Arg Gln His Glu Gln Gly Pro Gly 
            20                  25                  30          


Glu Glu Val Pro Asp Val Thr Pro Glu Glu Ala Leu Pro Glu Leu Pro 
        35                  40                  45              


Pro Gly Glu Pro Glu Phe Arg Cys Pro Glu Arg Val Met Asp Leu Gly 
    50                  55                  60                  


Leu Ser Glu Asp His Phe Ser Arg Pro Val Gly Leu Phe Leu Ala Ser 
65                  70                  75                  80  


Asp Val Gln Gln Leu Arg Gln Ala Ile Glu Glu Cys Lys Gln Val Ile 
                85                  90                  95      


Leu Glu Leu Pro Glu Gln Ser Glu Lys Gln Lys Asp Ala Val Val Arg 
            100                 105                 110         


Leu Ile His Leu Arg Leu Lys Leu Gln Glu Leu Lys Asp Pro Asn Glu 
        115                 120                 125             


Asp Glu Pro Asn Ile Arg Val Leu Leu Glu His Arg Phe Tyr Lys Glu 
    130                 135                 140                 


Lys Ser Lys Ser Val Lys Gln Thr Cys Asp Lys Cys Asn Thr Ile Ile 
145                 150                 155                 160 


Trp Gly Leu Ile Gln Thr Trp Tyr Thr Cys Thr Gly Cys Tyr Tyr Arg 
                165                 170                 175     


Cys His Ser Lys Cys Leu Asn Leu Ile Ser Lys Pro Cys Val Ser Ser 
            180                 185                 190         


Lys Val Ser His Gln Ala Glu Tyr Glu Leu Asn Ile Cys Pro Glu Thr 
        195                 200                 205             


Gly Leu Asp Ser Gln Asp Tyr Arg Cys Ala Glu Cys Arg Ala Pro Ile 
    210                 215                 220                 


Ser Leu Arg Gly Val Pro Ser Glu Ala Arg Gln Cys Asp Tyr Thr Gly 
225                 230                 235                 240 


Gln Tyr Tyr Cys Ser His Cys His Trp Asn Asp Leu Ala Val Ile Pro 
                245                 250                 255     


Ala Arg Val Val His Asn Trp Asp Phe Glu Pro Arg Lys Val Ser Arg 
            260                 265                 270         


Cys Ser Met Arg Tyr Leu Ala Leu Met Val Ser Arg Pro Val Leu Arg 
        275                 280                 285             


Leu Arg Glu Ile Asn Pro Leu Leu Phe Ser Tyr Val Glu Glu Leu Val 
    290                 295                 300                 


Glu Ile Arg Lys Leu Arg Gln Asp Ile Leu Leu Met Lys Pro Tyr Phe 
305                 310                 315                 320 


Ile Thr Cys Arg Glu Ala Met Glu Ala Arg Leu Leu Leu Gln Leu Gln 
                325                 330                 335     


Asp Arg Gln His Phe Val Glu Asn Asp Glu Met Tyr Ser Val Gln Asp 
            340                 345                 350         


Leu Leu Asp Val His Ala Gly Arg Leu Gly Cys Ser Leu Thr Glu Ile 
        355                 360                 365             


His Thr Leu Phe Ala Lys His Ile Lys Leu Asp Cys Glu Arg Cys Gln 
    370                 375                 380                 


Ala Lys Gly Phe Val Cys Glu Leu Cys Arg Glu Gly Asp Val Leu Phe 
385                 390                 395                 400 


Pro Phe Asp Ser His Thr Ser Val Cys Ala Asp Cys Ser Ala Val Phe 
                405                 410                 415     


His Arg Asp Cys Tyr Tyr Asp Asn Ser Thr Thr Cys Pro Lys Cys Ala 
            420                 425                 430         


Arg Leu Ser Leu Arg Lys Gln Ser Leu Phe Gln Glu Pro Gly Pro Asp 
        435                 440                 445             


Val Glu Ala 
    450     


<210>  4113
<211>  197
<212>  PRT
<213>  Homo Sapiens

<400>  4113

Met Glu Tyr Asp Glu Lys Leu Ala Arg Phe Arg Gln Ala His Leu Asn 
1               5                   10                  15      


Pro Phe Asn Lys Gln Ser Gly Pro Arg Gln His Glu Gln Gly Pro Gly 
            20                  25                  30          


Glu Glu Val Pro Asp Val Thr Pro Glu Glu Ala Leu Pro Glu Leu Pro 
        35                  40                  45              


Pro Gly Glu Pro Glu Phe Arg Cys Pro Glu Arg Val Met Asp Leu Gly 
    50                  55                  60                  


Leu Ser Glu Asp His Phe Ser Arg Pro Val Gly Leu Phe Leu Ala Ser 
65                  70                  75                  80  


Asp Val Gln Gln Leu Arg Gln Ala Ile Glu Glu Cys Lys Gln Val Ile 
                85                  90                  95      


Leu Glu Leu Pro Glu Gln Ser Glu Lys Gln Lys Asp Ala Val Val Arg 
            100                 105                 110         


Leu Ile His Leu Arg Leu Lys Leu Gln Glu Leu Lys Asp Pro Asn Glu 
        115                 120                 125             


Asp Glu Pro Asn Ile Arg Val Leu Leu Glu His Arg Phe Tyr Lys Glu 
    130                 135                 140                 


Lys Ser Lys Ser Val Lys Gln Thr Cys Asp Lys Cys Asn Thr Ile Ile 
145                 150                 155                 160 


Trp Gly Leu Ile Gln Thr Trp Tyr Thr Cys Thr Gly Gly Pro Arg Pro 
                165                 170                 175     


Arg Arg Gly Val Arg Asn Glu Arg Asp Gln Ser Ser Cys Leu Arg Trp 
            180                 185                 190         


Ala His Ile Gln Met 
        195         


<210>  4114
<211>  197
<212>  PRT
<213>  Homo Sapiens

<400>  4114

Met Glu Tyr Asp Glu Lys Leu Ala Arg Phe Arg Gln Ala His Leu Asn 
1               5                   10                  15      


Pro Phe Asn Lys Gln Ser Gly Pro Arg Gln His Glu Gln Gly Pro Gly 
            20                  25                  30          


Glu Glu Val Pro Asp Val Thr Pro Glu Glu Ala Leu Pro Glu Leu Pro 
        35                  40                  45              


Pro Gly Glu Pro Glu Phe Arg Cys Pro Glu Arg Val Met Asp Leu Gly 
    50                  55                  60                  


Leu Ser Glu Asp His Phe Ser Arg Pro Val Gly Leu Phe Leu Ala Ser 
65                  70                  75                  80  


Asp Val Gln Gln Leu Arg Gln Ala Ile Glu Glu Cys Lys Gln Val Ile 
                85                  90                  95      


Leu Glu Leu Pro Glu Gln Ser Glu Lys Gln Lys Asp Ala Val Val Arg 
            100                 105                 110         


Leu Ile His Leu Arg Leu Lys Leu Gln Glu Leu Lys Asp Pro Asn Glu 
        115                 120                 125             


Asp Glu Pro Asn Ile Arg Val Leu Leu Glu His Arg Phe Tyr Lys Glu 
    130                 135                 140                 


Lys Ser Lys Ser Val Lys Gln Thr Cys Asp Lys Cys Asn Thr Ile Ile 
145                 150                 155                 160 


Trp Gly Leu Ile Gln Thr Trp Tyr Thr Cys Thr Gly Gly Pro Arg Pro 
                165                 170                 175     


Arg Arg Gly Val Arg Asn Glu Arg Asp Gln Ser Ser Cys Leu Arg Trp 
            180                 185                 190         


Ala His Ile Gln Met 
        195         


<210>  4115
<211>  176
<212>  PRT
<213>  Homo Sapiens

<400>  4115

Met Glu Tyr Asp Glu Lys Leu Ala Arg Phe Arg Gln Ala His Leu Asn 
1               5                   10                  15      


Pro Phe Asn Lys Gln Ser Gly Pro Arg Gln His Glu Gln Gly Pro Gly 
            20                  25                  30          


Glu Glu Val Pro Asp Val Thr Pro Glu Glu Ala Leu Pro Glu Leu Pro 
        35                  40                  45              


Pro Gly Glu Pro Glu Phe Arg Cys Pro Glu Arg Val Met Asp Leu Gly 
    50                  55                  60                  


Leu Ser Glu Asp His Phe Ser Arg Pro Val Gly Leu Phe Leu Ala Ser 
65                  70                  75                  80  


Asp Val Gln Gln Leu Arg Gln Ala Ile Glu Glu Cys Lys Gln Val Ile 
                85                  90                  95      


Leu Glu Leu Pro Glu Gln Ser Glu Lys Gln Lys Asp Ala Val Val Arg 
            100                 105                 110         


Leu Ile His Leu Arg Leu Lys Leu Gln Glu Leu Lys Arg Cys Gln Ala 
        115                 120                 125             


Lys Gly Phe Val Cys Glu Leu Cys Arg Glu Gly Asp Val Leu Phe Pro 
    130                 135                 140                 


Phe Asp Ser His Thr Ser Val Cys Ala Asp Cys Ser Ala Val Phe His 
145                 150                 155                 160 


Arg Asp Cys Tyr Tyr Asp Asn Ser Thr Thr Cys Pro Lys Cys Ala Arg 
                165                 170                 175     


<210>  4116
<211>  441
<212>  PRT
<213>  Homo Sapiens

<400>  4116

Met Glu Tyr Asp Glu Lys Leu Ala Arg Phe Arg Gln Ala His Leu Asn 
1               5                   10                  15      


Pro Phe Asn Lys Gln Ser Gly Pro Arg Gln His Glu Gln Gly Pro Gly 
            20                  25                  30          


Glu Glu Val Pro Asp Val Thr Pro Glu Glu Ala Leu Pro Glu Leu Pro 
        35                  40                  45              


Pro Gly Glu Pro Glu Phe Arg Cys Pro Glu Arg Val Met Asp Leu Gly 
    50                  55                  60                  


Leu Ser Glu Asp His Phe Ser Arg Pro Val Leu Arg Gln Ala Ile Glu 
65                  70                  75                  80  


Glu Cys Lys Gln Val Ile Leu Glu Leu Pro Glu Gln Ser Glu Lys Gln 
                85                  90                  95      


Lys Asp Ala Val Val Arg Leu Ile His Leu Arg Leu Lys Leu Gln Glu 
            100                 105                 110         


Leu Lys Asp Pro Asn Glu Asp Glu Pro Asn Ile Arg Val Leu Leu Glu 
        115                 120                 125             


His Arg Phe Tyr Lys Glu Lys Ser Lys Ser Val Lys Gln Thr Cys Asp 
    130                 135                 140                 


Lys Cys Asn Thr Ile Ile Trp Gly Leu Ile Gln Thr Trp Tyr Thr Cys 
145                 150                 155                 160 


Thr Gly Cys Tyr Tyr Arg Cys His Ser Lys Cys Leu Asn Leu Ile Ser 
                165                 170                 175     


Lys Pro Cys Val Ser Ser Lys Val Ser His Gln Ala Glu Tyr Glu Leu 
            180                 185                 190         


Asn Ile Cys Pro Glu Thr Gly Leu Asp Ser Gln Asp Tyr Arg Cys Ala 
        195                 200                 205             


Glu Cys Arg Ala Pro Ile Ser Leu Arg Gly Val Pro Ser Glu Ala Arg 
    210                 215                 220                 


Gln Cys Asp Tyr Thr Gly Gln Tyr Tyr Cys Ser His Cys His Trp Asn 
225                 230                 235                 240 


Asp Leu Ala Val Ile Pro Ala Arg Val Val His Asn Trp Asp Phe Glu 
                245                 250                 255     


Pro Arg Lys Val Ser Arg Cys Ser Met Arg Tyr Leu Ala Leu Met Val 
            260                 265                 270         


Ser Arg Pro Val Leu Arg Leu Arg Glu Ile Asn Pro Leu Leu Phe Ser 
        275                 280                 285             


Tyr Val Glu Glu Leu Val Glu Ile Arg Lys Leu Arg Gln Asp Ile Leu 
    290                 295                 300                 


Leu Met Lys Pro Tyr Phe Ile Thr Cys Arg Glu Ala Met Glu Ala Arg 
305                 310                 315                 320 


Leu Leu Leu Gln Leu Gln Asp Arg Gln His Phe Val Glu Asn Asp Glu 
                325                 330                 335     


Met Tyr Ser Val Gln Asp Leu Leu Asp Val His Ala Gly Arg Leu Gly 
            340                 345                 350         


Cys Ser Leu Thr Glu Ile His Thr Leu Phe Ala Lys His Ile Lys Leu 
        355                 360                 365             


Asp Cys Glu Arg Cys Gln Ala Lys Gly Phe Val Cys Glu Leu Cys Arg 
    370                 375                 380                 


Glu Gly Asp Val Leu Phe Pro Phe Asp Ser His Thr Ser Val Cys Ala 
385                 390                 395                 400 


Asp Cys Ser Ala Val Phe His Arg Asp Cys Tyr Tyr Asp Asn Ser Thr 
                405                 410                 415     


Thr Cys Pro Lys Cys Ala Arg Leu Ser Leu Arg Lys Gln Ser Leu Phe 
            420                 425                 430         


Gln Glu Pro Gly Pro Asp Val Glu Ala 
        435                 440     


<210>  4117
<211>  127
<212>  PRT
<213>  Homo Sapiens

<400>  4117

Met Glu Tyr Asp Glu Lys Leu Ala Arg Phe Arg Gln Ala His Leu Asn 
1               5                   10                  15      


Pro Phe Asn Lys Gln Ser Gly Pro Arg Gln His Glu Gln Gly Pro Gly 
            20                  25                  30          


Glu Glu Val Pro Asp Val Thr Pro Glu Glu Ala Leu Pro Glu Leu Pro 
        35                  40                  45              


Pro Gly Glu Pro Glu Phe Arg Cys Pro Glu Arg Val Met Asp Leu Gly 
    50                  55                  60                  


Leu Ser Glu Asp His Phe Ser Arg Pro Val Gln Leu Arg Gln Ala Ile 
65                  70                  75                  80  


Glu Glu Cys Lys Gln Val Ile Leu Glu Leu Pro Glu Gln Ser Glu Lys 
                85                  90                  95      


Gln Lys Asp Ala Val Val Arg Leu Ile His Leu Arg Leu Lys Leu Gln 
            100                 105                 110         


Glu Leu Lys Asp Pro Asn Glu Asp Glu Pro Asn Ile Arg Val Leu 
        115                 120                 125         


<210>  4118
<211>  177
<212>  PRT
<213>  Homo Sapiens

<400>  4118

Met Arg Gly Gly Gly Gln Ala His Leu Asn Pro Phe Asn Lys Gln Ser 
1               5                   10                  15      


Gly Pro Arg Gln His Glu Gln Gly Pro Gly Glu Glu Val Pro Asp Val 
            20                  25                  30          


Thr Pro Glu Glu Ala Leu Pro Glu Leu Pro Pro Gly Glu Pro Glu Phe 
        35                  40                  45              


Arg Cys Pro Glu Arg Val Met Asp Leu Gly Leu Ser Glu Asp His Phe 
    50                  55                  60                  


Ser Arg Pro Val Gly Leu Phe Leu Ala Ser Asp Val Gln Gln Leu Arg 
65                  70                  75                  80  


Gln Ala Ile Glu Glu Cys Lys Gln Val Ile Leu Glu Leu Pro Glu Gln 
                85                  90                  95      


Ser Glu Lys Gln Lys Asp Ala Val Val Arg Leu Ile His Leu Arg Leu 
            100                 105                 110         


Lys Leu Gln Glu Leu Lys Asp Pro Asn Glu Asp Glu Pro Asn Ile Arg 
        115                 120                 125             


Val Leu Leu Glu His Arg Phe Tyr Lys Glu Lys Ser Lys Ser Val Lys 
    130                 135                 140                 


Gln Thr Cys Asp Lys Cys Asn Thr Ile Ile Trp Gly Leu Ile Gln Thr 
145                 150                 155                 160 


Trp Tyr Thr Cys Thr Gly Cys Tyr Tyr Arg Cys His Ser Lys Cys Leu 
                165                 170                 175     


Asn 
    


<210>  4119
<211>  186
<212>  PRT
<213>  Homo Sapiens

<400>  4119

Met Arg Gly Gly Gly Gln Val Leu Gly Val Ala Ala Ala Val Met Thr 
1               5                   10                  15      


Pro Leu Pro Gly Gly His Ala Ala Gly Arg Thr Arg Glu Ala Arg Trp 
            20                  25                  30          


Asp Ala Met Glu Tyr Asp Glu Lys Leu Ala Arg Phe Arg Gln Ala His 
        35                  40                  45              


Leu Asn Pro Phe Asn Lys Gln Ser Gly Pro Arg Gln His Glu Gln Gly 
    50                  55                  60                  


Pro Gly Glu Glu Val Pro Asp Val Thr Pro Glu Glu Ala Leu Pro Glu 
65                  70                  75                  80  


Leu Pro Pro Gly Glu Pro Glu Phe Arg Cys Pro Glu Arg Val Met Asp 
                85                  90                  95      


Leu Gly Leu Ser Glu Asp His Phe Ser Arg Pro Val Gly Leu Phe Leu 
            100                 105                 110         


Ala Ser Asp Val Gln Gln Leu Arg Gln Ala Ile Glu Glu Cys Lys Gln 
        115                 120                 125             


Val Ile Leu Glu Leu Pro Glu Gln Ser Glu Lys Gln Lys Asp Ala Val 
    130                 135                 140                 


Val Arg Leu Ile His Leu Arg Leu Lys Leu Gln Glu Leu Lys Asp Pro 
145                 150                 155                 160 


Asn Glu Asp Glu Pro Asn Ile Arg Val Leu Leu Glu His Arg Phe Tyr 
                165                 170                 175     


Lys Glu Lys Ser Lys Ser Val Lys Gln Thr 
            180                 185     


<210>  4120
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  4120

Met Arg Thr Leu Ala Ile Leu Ala Ala Ile Leu Leu Val Ala Leu Gln 
1               5                   10                  15      


Ala Gln Ala Glu Pro Leu Gln Ala Arg Ala Asp Glu Val Ala Ala Ala 
            20                  25                  30          


Pro Glu Gln Ile Ala Ala Asp Ile Pro Glu Val Val Val Ser Leu Ala 
        35                  40                  45              


Trp Asp Glu Ser Leu Ala Pro Lys His Pro Gly Ser Arg Lys Asn Met 
    50                  55                  60                  


Ala Cys Tyr Cys Arg Ile Pro Ala Cys Ile Ala Gly Glu Arg Arg Tyr 
65                  70                  75                  80  


Gly Thr Cys Ile Tyr Gln Gly Arg Leu Trp Ala Phe Cys Cys 
                85                  90                  


<210>  4121
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  4121

Met Arg Thr Leu Ala Ile Leu Ala Ala Ile Leu Leu Val Ala Leu Gln 
1               5                   10                  15      


Ala Gln Ala Glu Pro Leu Gln Ala Arg Ala Asp Glu Val Ala Ala Ala 
            20                  25                  30          


Pro Glu Gln Ile Ala Ala Asp Ile Pro Glu Val Val Val Ser Leu Ala 
        35                  40                  45              


Trp Asp Glu Ser Leu Ala Pro Lys His Pro Gly Ser Arg Lys Asn Met 
    50                  55                  60                  


Ala Cys Tyr Cys Arg Ile Pro Ala Cys Ile Ala Gly Glu Arg Arg Tyr 
65                  70                  75                  80  


Gly Thr Cys Ile Tyr Gln Gly Arg Leu Trp Ala Phe Cys Cys 
                85                  90                  


<210>  4122
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  4122

Met Arg Thr Leu Ala Ile Leu Ala Ala Ile Leu Leu Val Ala Leu Gln 
1               5                   10                  15      


Ala Gln Ala Glu Pro Leu Gln Ala Arg Ala Asp Glu Val Ala Ala Ala 
            20                  25                  30          


Pro Glu Gln Ile Ala Ala Asp Ile Pro Glu Val Val Val Ser Leu Ala 
        35                  40                  45              


Trp Asp Glu Ser Leu Ala Pro Lys His Pro Gly Ser Arg Lys Asn Met 
    50                  55                  60                  


Ala Cys Tyr Cys Arg Ile Pro Ala Cys Ile Ala Gly Glu Arg Arg Tyr 
65                  70                  75                  80  


Gly Thr Cys Ile Tyr Gln Gly Arg Leu Trp Ala Phe Cys Cys 
                85                  90                  


<210>  4123
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  4123

Met Arg Thr Leu Ala Ile Leu Ala Ala Ile Leu Leu Val Ala Leu Gln 
1               5                   10                  15      


Ala Gln Ala Glu Pro Leu Gln Ala Arg Ala Asp Glu Val Ala Ala Ala 
            20                  25                  30          


Pro Glu Gln Ile Ala Ala Asp Ile Pro Glu Val Val Val Ser Leu Ala 
        35                  40                  45              


Trp Asp Glu Ser Leu Ala Pro Lys His Pro Gly Ser Arg Lys Asn Met 
    50                  55                  60                  


Asp Cys Tyr Cys Arg Ile Pro Ala Cys Ile Ala Gly Glu Arg Arg Tyr 
65                  70                  75                  80  


Gly Thr Cys Ile Tyr Gln Gly Arg Leu Trp Ala Phe Cys Cys 
                85                  90                  


<210>  4124
<211>  97
<212>  PRT
<213>  Homo Sapiens

<400>  4124

Met Arg Ile Ile Ala Leu Leu Ala Ala Ile Leu Leu Val Ala Leu Gln 
1               5                   10                  15      


Val Arg Ala Gly Pro Leu Gln Ala Arg Gly Asp Glu Ala Pro Gly Gln 
            20                  25                  30          


Glu Gln Arg Gly Pro Glu Asp Gln Asp Ile Ser Ile Ser Phe Ala Trp 
        35                  40                  45              


Asp Lys Ser Ser Ala Leu Gln Val Ser Gly Ser Thr Arg Gly Met Val 
    50                  55                  60                  


Cys Ser Cys Arg Leu Val Phe Cys Arg Arg Thr Glu Leu Arg Val Gly 
65                  70                  75                  80  


Asn Cys Leu Ile Gly Gly Val Ser Phe Thr Tyr Cys Cys Thr Arg Val 
                85                  90                  95      


Asp 
    


<210>  4125
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  4125

Met Arg Thr Ile Ala Ile Leu Ala Ala Ile Leu Leu Val Ala Leu Gln 
1               5                   10                  15      


Ala Gln Ala Glu Ser Leu Gln Glu Arg Ala Asp Glu Ala Thr Thr Gln 
            20                  25                  30          


Lys Gln Ser Gly Glu Asp Asn Gln Asp Leu Ala Ile Ser Phe Ala Gly 
        35                  40                  45              


Asn Gly Leu Ser Ala Leu Arg Thr Ser Gly Ser Gln Ala Arg Ala Thr 
    50                  55                  60                  


Cys Tyr Cys Arg Thr Gly Arg Cys Ala Thr Arg Glu Ser Leu Ser Gly 
65                  70                  75                  80  


Val Cys Glu Ile Ser Gly Arg Leu Tyr Arg Leu Cys Cys Arg 
                85                  90                  


<210>  4126
<211>  100
<212>  PRT
<213>  Homo Sapiens

<400>  4126

Met Arg Thr Leu Thr Ile Leu Thr Ala Val Leu Leu Val Ala Leu Gln 
1               5                   10                  15      


Ala Lys Ala Glu Pro Leu Gln Ala Glu Asp Asp Pro Leu Gln Ala Lys 
            20                  25                  30          


Ala Tyr Glu Ala Asp Ala Gln Glu Gln Arg Gly Ala Asn Asp Gln Asp 
        35                  40                  45              


Phe Ala Val Ser Phe Ala Glu Asp Ala Ser Ser Ser Leu Arg Ala Leu 
    50                  55                  60                  


Gly Ser Thr Arg Ala Phe Thr Cys His Cys Arg Arg Ser Cys Tyr Ser 
65                  70                  75                  80  


Thr Glu Tyr Ser Tyr Gly Thr Cys Thr Val Met Gly Ile Asn His Arg 
                85                  90                  95      


Phe Cys Cys Leu 
            100 


<210>  4127
<211>  68
<212>  PRT
<213>  Homo Sapiens

<400>  4127

Met Arg Thr Ser Tyr Leu Leu Leu Phe Thr Leu Cys Leu Leu Leu Ser 
1               5                   10                  15      


Glu Met Ala Ser Gly Gly Asn Phe Leu Thr Gly Leu Gly His Arg Ser 
            20                  25                  30          


Asp His Tyr Asn Cys Val Ser Ser Gly Gly Gln Cys Leu Tyr Ser Ala 
        35                  40                  45              


Cys Pro Ile Phe Thr Lys Ile Gln Gly Thr Cys Tyr Arg Gly Lys Ala 
    50                  55                  60                  


Lys Cys Cys Lys 
65              


<210>  4128
<211>  67
<212>  PRT
<213>  Homo Sapiens

<400>  4128

Met Arg Ile His Tyr Leu Leu Phe Ala Leu Leu Phe Leu Phe Leu Val 
1               5                   10                  15      


Pro Val Pro Gly His Gly Gly Ile Ile Asn Thr Leu Gln Lys Tyr Tyr 
            20                  25                  30          


Cys Arg Val Arg Gly Gly Arg Cys Ala Val Leu Ser Cys Leu Pro Lys 
        35                  40                  45              


Glu Glu Gln Ile Gly Lys Cys Ser Thr Arg Gly Arg Lys Cys Cys Arg 
    50                  55                  60                  


Arg Lys Lys 
65          


<210>  4129
<211>  67
<212>  PRT
<213>  Homo Sapiens

<400>  4129

Met Arg Ile His Tyr Leu Leu Phe Ala Leu Leu Phe Leu Phe Leu Val 
1               5                   10                  15      


Pro Val Pro Gly His Gly Gly Ile Ile Asn Thr Leu Gln Lys Tyr Tyr 
            20                  25                  30          


Cys Arg Val Arg Gly Gly Arg Cys Ala Val Leu Ser Cys Leu Pro Lys 
        35                  40                  45              


Glu Glu Gln Ile Gly Lys Cys Ser Thr Arg Gly Arg Lys Cys Cys Arg 
    50                  55                  60                  


Arg Lys Lys 
65          


<210>  4130
<211>  72
<212>  PRT
<213>  Homo Sapiens

<400>  4130

Met Gln Arg Leu Val Leu Leu Leu Ala Ile Ser Leu Leu Leu Tyr Gln 
1               5                   10                  15      


Asp Leu Pro Val Arg Ser Glu Phe Glu Leu Asp Arg Ile Cys Gly Tyr 
            20                  25                  30          


Gly Thr Ala Arg Cys Arg Lys Lys Cys Arg Ser Gln Glu Tyr Arg Ile 
        35                  40                  45              


Gly Arg Cys Pro Asn Thr Tyr Ala Cys Cys Leu Arg Lys Trp Asp Glu 
    50                  55                  60                  


Ser Leu Leu Asn Arg Thr Lys Pro 
65                  70          


<210>  4131
<211>  72
<212>  PRT
<213>  Homo Sapiens

<400>  4131

Met Gln Arg Leu Val Leu Leu Leu Ala Ile Ser Leu Leu Leu Tyr Gln 
1               5                   10                  15      


Asp Leu Pro Val Arg Ser Glu Phe Glu Leu Asp Arg Ile Cys Gly Tyr 
            20                  25                  30          


Gly Thr Ala Arg Cys Arg Lys Lys Cys Arg Ser Gln Glu Tyr Arg Ile 
        35                  40                  45              


Gly Arg Cys Pro Asn Thr Tyr Ala Cys Cys Leu Arg Lys Trp Asp Glu 
    50                  55                  60                  


Ser Leu Leu Asn Arg Thr Lys Pro 
65                  70          


<210>  4132
<211>  78
<212>  PRT
<213>  Homo Sapiens

<400>  4132

Met Ala Leu Ile Arg Lys Thr Phe Tyr Phe Leu Phe Ala Met Phe Phe 
1               5                   10                  15      


Ile Leu Val Gln Leu Pro Ser Gly Cys Gln Ala Gly Leu Asp Phe Ser 
            20                  25                  30          


Gln Pro Phe Pro Ser Gly Glu Phe Ala Val Cys Glu Ser Cys Lys Leu 
        35                  40                  45              


Gly Arg Gly Lys Cys Arg Lys Glu Cys Leu Glu Asn Glu Lys Pro Asp 
    50                  55                  60                  


Gly Asn Cys Arg Leu Asn Phe Leu Cys Cys Arg Gln Arg Ile 
65                  70                  75              


<210>  4133
<211>  78
<212>  PRT
<213>  Homo Sapiens

<400>  4133

Met Ala Leu Ile Arg Lys Thr Phe Tyr Phe Leu Phe Ala Met Phe Phe 
1               5                   10                  15      


Ile Leu Val Gln Leu Pro Ser Gly Cys Gln Ala Gly Leu Asp Phe Ser 
            20                  25                  30          


Gln Pro Phe Pro Ser Gly Glu Phe Ala Val Cys Glu Ser Cys Lys Leu 
        35                  40                  45              


Gly Arg Gly Lys Cys Arg Lys Glu Cys Leu Glu Asn Glu Lys Pro Asp 
    50                  55                  60                  


Gly Asn Cys Arg Leu Asn Phe Leu Cys Cys Arg Gln Arg Ile 
65                  70                  75              


<210>  4134
<211>  65
<212>  PRT
<213>  Homo Sapiens

<400>  4134

Met Arg Thr Phe Leu Phe Leu Phe Ala Val Leu Phe Phe Leu Thr Pro 
1               5                   10                  15      


Ala Lys Asn Ala Phe Phe Asp Glu Lys Cys Asn Lys Leu Lys Gly Thr 
            20                  25                  30          


Cys Lys Asn Asn Cys Gly Lys Asn Glu Glu Leu Ile Ala Leu Cys Gln 
        35                  40                  45              


Lys Ser Leu Lys Cys Cys Arg Thr Ile Gln Pro Cys Gly Ser Ile Ile 
    50                  55                  60                  


Asp 
65  


<210>  4135
<211>  65
<212>  PRT
<213>  Homo Sapiens

<400>  4135

Met Arg Thr Phe Leu Phe Leu Phe Ala Val Leu Phe Phe Leu Thr Pro 
1               5                   10                  15      


Ala Lys Asn Ala Phe Phe Asp Glu Lys Cys Asn Lys Leu Lys Gly Thr 
            20                  25                  30          


Cys Lys Asn Asn Cys Gly Lys Asn Glu Glu Leu Ile Ala Leu Cys Gln 
        35                  40                  45              


Lys Ser Leu Lys Cys Cys Arg Thr Ile Gln Pro Cys Gly Ser Ile Ile 
    50                  55                  60                  


Asp 
65  


<210>  4136
<211>  70
<212>  PRT
<213>  Homo Sapiens

<400>  4136

Met Pro Gly Ala Met Lys Ile Phe Val Phe Ile Leu Ala Ala Leu Ile 
1               5                   10                  15      


Leu Leu Ala Gln Ile Phe Gln Ala Arg Thr Ala Ile His Arg Ala Leu 
            20                  25                  30          


Ile Ser Lys Arg Met Glu Gly His Cys Glu Ala Glu Cys Leu Thr Phe 
        35                  40                  45              


Glu Val Lys Ile Gly Gly Cys Arg Ala Glu Leu Ala Pro Phe Cys Cys 
    50                  55                  60                  


Lys Asn Arg Lys Lys His 
65                  70  


<210>  4137
<211>  70
<212>  PRT
<213>  Homo Sapiens

<400>  4137

Met Pro Gly Ala Met Lys Ile Phe Val Phe Ile Leu Ala Ala Leu Ile 
1               5                   10                  15      


Leu Leu Ala Gln Ile Phe Gln Ala Arg Thr Ala Ile His Arg Ala Leu 
            20                  25                  30          


Ile Ser Lys Arg Met Glu Gly His Cys Glu Ala Glu Cys Leu Thr Phe 
        35                  40                  45              


Glu Val Lys Ile Gly Gly Cys Arg Ala Glu Leu Ala Pro Phe Cys Cys 
    50                  55                  60                  


Lys Asn Arg Lys Lys His 
65                  70  


<210>  4138
<211>  73
<212>  PRT
<213>  Homo Sapiens

<400>  4138

Met Arg Ile Ala Val Leu Leu Phe Ala Ile Phe Phe Phe Met Ser Gln 
1               5                   10                  15      


Val Leu Pro Ala Arg Gly Lys Phe Lys Glu Ile Cys Glu Arg Pro Asn 
            20                  25                  30          


Gly Ser Cys Arg Asp Phe Cys Leu Glu Thr Glu Ile His Val Gly Arg 
        35                  40                  45              


Cys Leu Asn Ser Gln Pro Cys Cys Leu Pro Leu Gly His Gln Pro Arg 
    50                  55                  60                  


Ile Glu Ser Thr Thr Pro Lys Lys Asp 
65                  70              


<210>  4139
<211>  67
<212>  PRT
<213>  Homo Sapiens

<400>  4139

Met Lys Ile Gln Leu Phe Phe Phe Ile Leu His Phe Trp Val Thr Ile 
1               5                   10                  15      


Leu Pro Ala Lys Lys Lys Tyr Pro Glu Tyr Gly Ser Leu Asp Leu Arg 
            20                  25                  30          


Arg Glu Cys Arg Ile Gly Asn Gly Gln Cys Lys Asn Gln Cys His Glu 
        35                  40                  45              


Asn Glu Ile Arg Ile Ala Tyr Cys Ile Arg Pro Gly Thr His Cys Cys 
    50                  55                  60                  


Leu Gln Gln 
65          


<210>  4140
<211>  62
<212>  PRT
<213>  Homo Sapiens

<400>  4140

Met Lys Ile Gln Leu Phe Phe Phe Ile Leu His Phe Trp Val Thr Ile 
1               5                   10                  15      


Leu Pro Ala Arg Ser Asn Phe Glu Pro Lys Tyr Arg Phe Glu Arg Cys 
            20                  25                  30          


Glu Lys Val Arg Gly Ile Cys Lys Thr Phe Cys Asp Asp Val Glu Tyr 
        35                  40                  45              


Asp Tyr Gly Tyr Cys Ile Lys Trp Arg Ser Gln Cys Cys Val 
    50                  55                  60          


<210>  4141
<211>  82
<212>  PRT
<213>  Homo Sapiens

<400>  4141

Met Lys Ile Leu Cys Ile Phe Leu Thr Phe Val Phe Thr Val Ser Cys 
1               5                   10                  15      


Gly Pro Ser Val Pro Gln Lys Lys Thr Arg Glu Val Ala Glu Arg Lys 
            20                  25                  30          


Arg Glu Cys Gln Leu Val Arg Gly Ala Cys Lys Pro Glu Cys Asn Ser 
        35                  40                  45              


Trp Glu Tyr Val Tyr Tyr Tyr Cys Asn Val Asn Pro Cys Cys Ala Val 
    50                  55                  60                  


Trp Glu Tyr Gln Lys Pro Ile Ile Asn Lys Ile Thr Ser Lys Leu His 
65                  70                  75                  80  


Gln Lys 
        


<210>  4142
<211>  69
<212>  PRT
<213>  Homo Sapiens

<400>  4142

Met Arg Ile Phe Tyr Tyr Leu His Phe Leu Cys Tyr Val Thr Phe Ile 
1               5                   10                  15      


Leu Pro Ala Thr Cys Thr Leu Val Asn Ala Asp Arg Cys Thr Lys Arg 
            20                  25                  30          


Tyr Gly Arg Cys Lys Arg Asp Cys Leu Glu Ser Glu Lys Gln Ile Asp 
        35                  40                  45              


Ile Cys Ser Leu Pro Arg Lys Ile Cys Cys Thr Glu Lys Leu Tyr Glu 
    50                  55                  60                  


Glu Asp Asp Met Phe 
65                  


<210>  4143
<211>  88
<212>  PRT
<213>  Homo Sapiens

<400>  4143

Met Leu Pro Asp His Phe Ser Pro Leu Ser Gly Asp Ile Lys Leu Ser 
1               5                   10                  15      


Val Leu Ala Leu Val Val Leu Val Val Leu Ala Gln Thr Ala Pro Asp 
            20                  25                  30          


Gly Trp Ile Arg Arg Cys Tyr Tyr Gly Thr Gly Arg Cys Arg Lys Ser 
        35                  40                  45              


Cys Lys Glu Ile Glu Arg Lys Lys Glu Lys Cys Gly Glu Lys His Ile 
    50                  55                  60                  


Cys Cys Val Pro Lys Glu Lys Asp Lys Leu Ser His Ile His Asp Gln 
65                  70                  75                  80  


Lys Glu Thr Ser Glu Leu Tyr Ile 
                85              


<210>  4144
<211>  102
<212>  PRT
<213>  Homo Sapiens

<400>  4144

Met Ser Val Met Lys Pro Cys Leu Met Thr Ile Ala Ile Leu Met Ile 
1               5                   10                  15      


Leu Ala Gln Lys Thr Pro Gly Gly Leu Phe Arg Ser His Asn Gly Lys 
            20                  25                  30          


Ser Arg Glu Pro Trp Asn Pro Cys Glu Leu Tyr Gln Gly Met Cys Arg 
        35                  40                  45              


Asn Ala Cys Arg Glu Tyr Glu Ile Gln Tyr Leu Thr Cys Pro Asn Asp 
    50                  55                  60                  


Gln Lys Cys Cys Leu Lys Leu Ser Val Lys Ile Thr Ser Ser Lys Asn 
65                  70                  75                  80  


Val Lys Glu Asp Tyr Asp Ser Asn Ser Asn Leu Ser Val Thr Asn Ser 
                85                  90                  95      


Ser Ser Tyr Ser His Ile 
            100         


<210>  4145
<211>  123
<212>  PRT
<213>  Homo Sapiens

<400>  4145

Met Lys Leu Leu Leu Leu Ala Leu Pro Met Leu Val Leu Leu Pro Gln 
1               5                   10                  15      


Val Ile Pro Ala Tyr Ser Gly Glu Lys Lys Cys Trp Asn Arg Ser Gly 
            20                  25                  30          


His Cys Arg Lys Gln Cys Lys Asp Gly Glu Ala Val Lys Asp Thr Cys 
        35                  40                  45              


Lys Asn Leu Arg Ala Cys Cys Ile Pro Ser Asn Glu Asp His Arg Arg 
    50                  55                  60                  


Val Pro Ala Thr Ser Pro Thr Pro Leu Ser Asp Ser Thr Pro Gly Ile 
65                  70                  75                  80  


Ile Asp Asp Ile Leu Thr Val Arg Phe Thr Thr Asp Tyr Phe Glu Val 
                85                  90                  95      


Ser Ser Lys Lys Asp Met Val Glu Glu Ser Glu Ala Gly Arg Gly Thr 
            100                 105                 110         


Glu Thr Ser Leu Pro Asn Val His His Ser Ser 
        115                 120             


<210>  4146
<211>  43
<212>  PRT
<213>  Homo Sapiens

<400>  4146

Met Lys Leu Leu Tyr Leu Phe Leu Ala Ile Leu Leu Ala Ile Glu Glu 
1               5                   10                  15      


Pro Val Ile Ser Ala Leu Val Arg Thr Val Gly Cys Cys Leu Asp Thr 
            20                  25                  30          


Ala Arg Gln Thr Pro His Pro Ser Met His Gly 
        35                  40              


<210>  4147
<211>  84
<212>  PRT
<213>  Homo Sapiens

<400>  4147

Met Lys Leu Leu Tyr Leu Phe Leu Ala Ile Leu Leu Ala Ile Glu Glu 
1               5                   10                  15      


Pro Val Ile Ser Gly Lys Arg His Ile Leu Arg Cys Met Gly Asn Ser 
            20                  25                  30          


Gly Ile Cys Arg Ala Ser Cys Lys Lys Asn Glu Gln Pro Tyr Leu Tyr 
        35                  40                  45              


Cys Arg Asn Cys Gln Ser Cys Cys Leu Gln Ser Tyr Met Arg Ile Ser 
    50                  55                  60                  


Ile Ser Gly Lys Glu Glu Asn Thr Asp Trp Ser Tyr Glu Lys Gln Trp 
65                  70                  75                  80  


Pro Arg Leu Pro 
                


<210>  4148
<211>  88
<212>  PRT
<213>  Homo Sapiens

<400>  4148

Met Lys Leu Leu Tyr Leu Phe Leu Ala Ile Leu Leu Ala Ile Glu Glu 
1               5                   10                  15      


Pro Val Ile Ser Val Glu Cys Trp Met Asp Gly His Cys Arg Leu Leu 
            20                  25                  30          


Cys Lys Asp Gly Glu Asp Ser Ile Ile Arg Cys Arg Asn Arg Lys Arg 
        35                  40                  45              


Cys Cys Val Pro Ser Arg Tyr Leu Thr Ile Gln Pro Val Thr Ile His 
    50                  55                  60                  


Gly Ile Leu Gly Trp Thr Thr Pro Gln Met Ser Thr Thr Ala Pro Lys 
65                  70                  75                  80  


Met Lys Thr Asn Ile Thr Asn Arg 
                85              


<210>  4149
<211>  76
<212>  PRT
<213>  Homo Sapiens

<400>  4149

Met Lys Leu Leu Leu Leu Leu Leu Thr Val Thr Leu Leu Leu Ala Gln 
1               5                   10                  15      


Val Thr Pro Val Met Lys Cys Trp Gly Lys Ser Gly Arg Cys Arg Thr 
            20                  25                  30          


Thr Cys Lys Glu Ser Glu Val Tyr Tyr Ile Leu Cys Lys Thr Glu Ala 
        35                  40                  45              


Lys Cys Cys Val Asp Pro Lys Tyr Val Pro Val Lys Pro Lys Leu Thr 
    50                  55                  60                  


Asp Thr Asn Thr Ser Leu Glu Ser Thr Ser Ala Val 
65                  70                  75      


<210>  4150
<211>  67
<212>  PRT
<213>  Homo Sapiens

<400>  4150

Met Lys Leu Leu Leu Leu Thr Leu Thr Val Leu Leu Leu Leu Ser Gln 
1               5                   10                  15      


Leu Thr Pro Gly Gly Thr Gln Arg Cys Trp Asn Leu Tyr Gly Lys Cys 
            20                  25                  30          


Arg Tyr Arg Cys Ser Lys Lys Glu Arg Val Tyr Val Tyr Cys Ile Asn 
        35                  40                  45              


Asn Lys Met Cys Cys Val Lys Pro Lys Tyr Gln Pro Lys Glu Arg Trp 
    50                  55                  60                  


Trp Pro Phe 
65          


<210>  4151
<211>  71
<212>  PRT
<213>  Homo Sapiens

<400>  4151

Met Thr Gln Leu Leu Leu Phe Leu Val Ala Leu Leu Val Leu Gly His 
1               5                   10                  15      


Val Pro Ser Gly Arg Ser Glu Phe Lys Arg Cys Trp Lys Gly Gln Gly 
            20                  25                  30          


Ala Cys Gln Thr Tyr Cys Thr Arg Gln Glu Thr Tyr Met His Leu Cys 
        35                  40                  45              


Pro Asp Ala Ser Leu Cys Cys Leu Ser Tyr Ala Leu Lys Pro Pro Pro 
    50                  55                  60                  


Val Pro Lys His Glu Tyr Glu 
65                  70      


<210>  4152
<211>  156
<212>  PRT
<213>  Homo Sapiens

<400>  4152

Met Asn Ile Leu Met Leu Thr Phe Ile Ile Cys Gly Leu Leu Thr Arg 
1               5                   10                  15      


Val Thr Lys Gly Ser Phe Glu Pro Gln Lys Cys Trp Lys Asn Asn Val 
            20                  25                  30          


Gly His Cys Arg Arg Arg Cys Leu Asp Thr Glu Arg Tyr Ile Leu Leu 
        35                  40                  45              


Cys Arg Asn Lys Leu Ser Cys Cys Ile Ser Ile Ile Ser His Glu Tyr 
    50                  55                  60                  


Thr Arg Arg Pro Ala Phe Pro Val Ile His Leu Glu Asp Ile Thr Leu 
65                  70                  75                  80  


Asp Tyr Ser Asp Val Asp Ser Phe Thr Gly Ser Pro Val Ser Met Leu 
                85                  90                  95      


Asn Asp Leu Ile Thr Phe Asp Thr Thr Lys Phe Gly Glu Thr Met Thr 
            100                 105                 110         


Pro Glu Thr Asn Thr Pro Glu Thr Thr Met Pro Pro Ser Glu Ala Thr 
        115                 120                 125             


Thr Pro Glu Thr Thr Met Pro Pro Ser Glu Thr Ala Thr Ser Glu Thr 
    130                 135                 140                 


Met Pro Pro Pro Ser Gln Thr Ala Leu Thr His Asn 
145                 150                 155     


<210>  4153
<211>  111
<212>  PRT
<213>  Homo Sapiens

<400>  4153

Met Lys Ser Leu Leu Phe Thr Leu Ala Val Phe Met Leu Leu Ala Gln 
1               5                   10                  15      


Leu Val Ser Gly Asn Trp Tyr Val Lys Lys Cys Leu Asn Asp Val Gly 
            20                  25                  30          


Ile Cys Lys Lys Lys Cys Lys Pro Glu Glu Met His Val Lys Asn Gly 
        35                  40                  45              


Trp Ala Met Cys Gly Lys Gln Arg Asp Cys Cys Val Pro Ala Asp Arg 
    50                  55                  60                  


Arg Ala Asn Tyr Pro Val Phe Cys Val Gln Thr Lys Thr Thr Arg Ile 
65                  70                  75                  80  


Ser Thr Val Thr Ala Thr Thr Ala Thr Thr Thr Leu Met Met Thr Thr 
                85                  90                  95      


Ala Ser Met Ser Ser Met Ala Pro Thr Pro Val Ser Pro Thr Gly 
            100                 105                 110     


<210>  4154
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  4154

Met Gly Leu Phe Met Ile Ile Ala Ile Leu Leu Phe Gln Lys Pro Thr 
1               5                   10                  15      


Val Thr Glu Gln Leu Lys Lys Cys Trp Asn Asn Tyr Val Gln Gly His 
            20                  25                  30          


Cys Arg Lys Ile Cys Arg Val Asn Glu Val Pro Glu Ala Leu Cys Glu 
        35                  40                  45              


Asn Gly Arg Tyr Cys Cys Leu Asn Ile Lys Glu Leu Glu Ala Cys Lys 
    50                  55                  60                  


Lys Ile Thr Lys Pro Pro Arg Pro Lys Pro Ala Thr Leu Ala Leu Thr 
65                  70                  75                  80  


Leu Gln Asp Tyr Val Thr Ile Ile Glu Asn Phe Pro Ser Leu Lys Thr 
                85                  90                  95      


Gln Ser Thr 
            


<210>  4155
<211>  93
<212>  PRT
<213>  Homo Sapiens

<400>  4155

Met Lys Leu Phe Leu Val Leu Ile Ile Leu Leu Phe Glu Val Leu Thr 
1               5                   10                  15      


Asp Gly Ala Arg Leu Lys Lys Cys Phe Asn Lys Val Thr Gly Tyr Cys 
            20                  25                  30          


Arg Lys Lys Cys Lys Val Gly Glu Arg Tyr Glu Ile Gly Cys Leu Ser 
        35                  40                  45              


Gly Lys Leu Cys Cys Ala Asn Asp Glu Glu Glu Lys Lys His Val Ser 
    50                  55                  60                  


Phe Lys Lys Pro His Gln His Ser Gly Glu Lys Leu Ser Val Leu Gln 
65                  70                  75                  80  


Asp Tyr Ile Ile Leu Pro Thr Ile Thr Ile Phe Thr Val 
                85                  90              


<210>  4156
<211>  183
<212>  PRT
<213>  Homo Sapiens

<400>  4156

Met Lys Leu Leu Phe Pro Ile Phe Ala Ser Leu Met Leu Gln Tyr Gln 
1               5                   10                  15      


Val Asn Thr Glu Phe Ile Gly Leu Arg Arg Cys Leu Met Gly Leu Gly 
            20                  25                  30          


Arg Cys Arg Asp His Cys Asn Val Asp Glu Lys Glu Ile Gln Lys Cys 
        35                  40                  45              


Lys Met Lys Lys Cys Cys Val Gly Pro Lys Val Val Lys Leu Ile Lys 
    50                  55                  60                  


Asn Tyr Leu Gln Tyr Gly Thr Pro Asn Val Leu Asn Glu Asp Val Gln 
65                  70                  75                  80  


Glu Met Leu Lys Pro Ala Lys Asn Ser Ser Ala Val Ile Gln Arg Lys 
                85                  90                  95      


His Ile Leu Ser Val Leu Pro Gln Ile Lys Ser Thr Ser Phe Phe Ala 
            100                 105                 110         


Asn Thr Asn Phe Val Ile Ile Pro Asn Ala Thr Pro Met Asn Ser Ala 
        115                 120                 125             


Thr Ile Ser Thr Met Thr Pro Gly Gln Ile Thr Tyr Thr Ala Thr Ser 
    130                 135                 140                 


Thr Lys Ser Asn Thr Lys Glu Ser Arg Asp Ser Ala Thr Ala Ser Pro 
145                 150                 155                 160 


Pro Pro Ala Pro Pro Pro Pro Asn Ile Leu Pro Thr Pro Ser Leu Glu 
                165                 170                 175     


Leu Glu Glu Ala Glu Glu Gln 
            180             


<210>  4157
<211>  79
<212>  PRT
<213>  Homo Sapiens

<400>  4157

Met Lys Leu His Ser Leu Ile Ser Val Leu Leu Leu Phe Val Thr Leu 
1               5                   10                  15      


Ile Pro Lys Gly Lys Thr Gly Val Ile Pro Gly Gln Lys Gln Cys Ile 
            20                  25                  30          


Ala Leu Lys Gly Val Cys Arg Asp Lys Leu Cys Ser Thr Leu Asp Asp 
        35                  40                  45              


Thr Ile Gly Ile Cys Asn Glu Gly Lys Lys Cys Cys Arg Arg Trp Trp 
    50                  55                  60                  


Ile Leu Glu Pro Tyr Pro Thr Pro Val Pro Lys Gly Lys Ser Pro 
65                  70                  75                  


<210>  4158
<211>  79
<212>  PRT
<213>  Homo Sapiens

<400>  4158

Met Lys Leu His Ser Leu Ile Ser Val Leu Leu Leu Phe Val Thr Leu 
1               5                   10                  15      


Ile Pro Lys Gly Lys Thr Gly Val Ile Pro Gly Gln Lys Gln Cys Ile 
            20                  25                  30          


Ala Leu Lys Gly Val Cys Arg Asp Lys Leu Cys Ser Thr Leu Asp Asp 
        35                  40                  45              


Thr Ile Gly Ile Cys Asn Glu Gly Lys Lys Cys Cys Arg Arg Trp Trp 
    50                  55                  60                  


Ile Leu Glu Pro Tyr Pro Thr Pro Val Pro Lys Gly Lys Ser Pro 
65                  70                  75                  


<210>  4159
<211>  70
<212>  PRT
<213>  Homo Sapiens

<400>  4159

Met Arg Val Leu Phe Phe Val Phe Gly Val Leu Ser Leu Met Phe Thr 
1               5                   10                  15      


Val Pro Pro Ala Arg Ser Phe Ile Ser Asn Asp Glu Cys Pro Ser Glu 
            20                  25                  30          


Tyr Tyr His Cys Arg Leu Lys Cys Asn Ala Asp Glu His Ala Ile Arg 
        35                  40                  45              


Tyr Cys Ala Asp Phe Ser Ile Cys Cys Lys Leu Lys Ile Ile Glu Ile 
    50                  55                  60                  


Asp Gly Gln Lys Lys Trp 
65                  70  


<210>  4160
<211>  70
<212>  PRT
<213>  Homo Sapiens

<400>  4160

Met Arg Val Leu Phe Phe Val Phe Gly Val Leu Ser Leu Met Ser Thr 
1               5                   10                  15      


Val Pro Pro Thr Arg Ser Phe Thr Ser Asn Asp Glu Cys Pro Ser Glu 
            20                  25                  30          


Tyr Tyr His Cys Arg Leu Lys Cys Asn Ala Asp Glu His Ala Ile Arg 
        35                  40                  45              


Tyr Cys Ala Asp Phe Ser Ile Cys Cys Lys Leu Lys Ile Ile Gln Ile 
    50                  55                  60                  


Asp Gly Gln Lys Lys Trp 
65                  70  


<210>  4161
<211>  95
<212>  PRT
<213>  Homo Sapiens

<400>  4161

Met Lys Phe Leu Leu Leu Val Leu Ala Ala Leu Gly Phe Leu Thr Gln 
1               5                   10                  15      


Val Ile Pro Ala Ser Ala Gly Gly Ser Lys Cys Val Ser Asn Thr Pro 
            20                  25                  30          


Gly Tyr Cys Arg Thr Cys Cys His Trp Gly Glu Thr Ala Leu Phe Met 
        35                  40                  45              


Cys Asn Ala Ser Arg Lys Cys Cys Ile Ser Tyr Ser Phe Leu Pro Lys 
    50                  55                  60                  


Pro Asp Leu Pro Gln Leu Ile Gly Asn His Trp Gln Ser Arg Arg Arg 
65                  70                  75                  80  


Asn Thr Gln Arg Lys Asp Lys Lys Gln Gln Thr Thr Val Thr Ser 
                85                  90                  95  


<210>  4162
<211>  61
<212>  PRT
<213>  Homo Sapiens

<400>  4162

Met Lys Ile His Val Phe Leu Phe Val Leu Phe Phe Phe Leu Val Pro 
1               5                   10                  15      


Ile Ala Thr Arg Val Lys Cys Ala Val Lys Asp Thr Tyr Ser Cys Phe 
            20                  25                  30          


Ile Met Arg Gly Lys Cys Arg His Glu Cys His Asp Phe Glu Lys Pro 
        35                  40                  45              


Ile Gly Phe Cys Thr Lys Leu Asn Ala Asn Cys Tyr Met 
    50                  55                  60      


<210>  4163
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  4163

Met Lys Pro Leu Leu Val Val Phe Val Phe Leu Phe Leu Trp Asp Pro 
1               5                   10                  15      


Val Leu Ala Gly Ile Asn Ser Leu Ser Ser Glu Met His Lys Lys Cys 
            20                  25                  30          


Tyr Lys Asn Gly Ile Cys Arg Leu Glu Cys Tyr Glu Ser Glu Met Leu 
        35                  40                  45              


Val Ala Tyr Cys Met Phe Gln Leu Glu Cys Cys Val Lys Gly Asn Pro 
    50                  55                  60                  


Ala Pro 
65      


<210>  4164
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  4164

Met Lys Pro Leu Leu Val Val Phe Val Phe Leu Phe Leu Trp Asp Pro 
1               5                   10                  15      


Val Leu Ala Gly Ile Asn Ser Leu Ser Ser Glu Met His Lys Lys Cys 
            20                  25                  30          


Tyr Lys Asn Gly Ile Cys Arg Leu Glu Cys Tyr Glu Ser Glu Met Leu 
        35                  40                  45              


Val Ala Tyr Cys Met Phe Gln Leu Glu Cys Cys Val Lys Gly Asn Pro 
    50                  55                  60                  


Ala Pro 
65      


<210>  4165
<211>  77
<212>  PRT
<213>  Homo Sapiens

<400>  4165

Met Ala Thr Arg Ser Val Leu Leu Ala Leu Val Val Leu Asn Leu Leu 
1               5                   10                  15      


Phe Tyr Val Pro Pro Gly Arg Ser Gly Pro Asn Val Tyr Ile Gln Lys 
            20                  25                  30          


Ile Phe Ala Ser Cys Trp Arg Leu Gln Gly Thr Cys Arg Pro Lys Cys 
        35                  40                  45              


Leu Lys Asn Glu Gln Tyr Arg Ile Leu Cys Asp Thr Ile His Leu Cys 
    50                  55                  60                  


Cys Val Asn Pro Lys Tyr Leu Pro Ile Leu Thr Gly Lys 
65                  70                  75          


<210>  4166
<211>  78
<212>  PRT
<213>  Homo Sapiens

<400>  4166

Met Asn Leu Cys Leu Ser Ala Leu Leu Phe Phe Leu Val Ile Leu Leu 
1               5                   10                  15      


Pro Ser Gly Lys Gly Met Phe Gly Asn Asp Gly Val Lys Val Arg Thr 
            20                  25                  30          


Cys Thr Ser Gln Lys Ala Val Cys Phe Phe Gly Cys Pro Pro Gly Tyr 
        35                  40                  45              


Arg Trp Ile Ala Phe Cys His Asn Ile Leu Ser Cys Cys Lys Asn Met 
    50                  55                  60                  


Thr Arg Phe Gln Pro Pro Gln Ala Lys Asp Pro Trp Val His 
65                  70                  75              


<210>  4167
<211>  64
<212>  PRT
<213>  Homo Sapiens

<400>  4167

Met Arg Val Leu Tyr Leu Leu Phe Ser Phe Leu Phe Ile Phe Leu Met 
1               5                   10                  15      


Pro Leu Pro Gly Val Phe Gly Gly Ile Gly Asp Pro Val Thr Cys Leu 
            20                  25                  30          


Lys Ser Gly Ala Ile Cys His Pro Val Phe Cys Pro Arg Arg Tyr Lys 
        35                  40                  45              


Gln Ile Gly Thr Cys Gly Leu Pro Gly Thr Lys Cys Cys Lys Lys Pro 
    50                  55                  60                  


<210>  4168
<211>  64
<212>  PRT
<213>  Homo Sapiens

<400>  4168

Met Arg Val Leu Tyr Leu Leu Phe Ser Phe Leu Phe Ile Phe Leu Met 
1               5                   10                  15      


Pro Leu Pro Gly Val Phe Gly Gly Ile Gly Asp Pro Val Thr Cys Leu 
            20                  25                  30          


Lys Ser Gly Ala Ile Cys His Pro Val Phe Cys Pro Arg Arg Tyr Lys 
        35                  40                  45              


Gln Ile Gly Thr Cys Gly Leu Pro Gly Thr Lys Cys Cys Lys Lys Pro 
    50                  55                  60                  


<210>  4169
<211>  84
<212>  PRT
<213>  Homo Sapiens

<400>  4169

Met Arg Ser Arg Leu Leu Leu Ser Val Ala His Leu Pro Thr Ile Arg 
1               5                   10                  15      


Glu Thr Thr Glu Glu Met Leu Leu Gly Gly Pro Gly Gln Glu Pro Pro 
            20                  25                  30          


Pro Ser Pro Ser Leu Asp Asp Tyr Val Arg Ser Ile Ser Arg Leu Ala 
        35                  40                  45              


Gln Pro Thr Ser Val Leu Asp Lys Ala Thr Ala Gln Gly Gln Pro Arg 
    50                  55                  60                  


Pro Pro His Arg Pro Ala Gln Ala Cys Arg Lys Gly Arg Pro Ala Val 
65                  70                  75                  80  


Ser Leu Arg Asp 
                


<210>  4170
<211>  212
<212>  PRT
<213>  Homo Sapiens

<400>  4170

Met Arg Ser Arg Leu Leu Leu Ser Val Ala His Leu Pro Thr Ile Arg 
1               5                   10                  15      


Glu Thr Thr Glu Glu Met Leu Leu Gly Gly Pro Gly Gln Glu Pro Pro 
            20                  25                  30          


Pro Ser Pro Ser Leu Asp Asp Tyr Val Arg Ser Ile Ser Arg Leu Ala 
        35                  40                  45              


Gln Pro Thr Ser Val Leu Asp Lys Ala Thr Ala Gln Gly Gln Pro Arg 
    50                  55                  60                  


Pro Pro His Arg Pro Ala Gln Ala Cys Arg Lys Gly Arg Pro Ala Val 
65                  70                  75                  80  


Ser Leu Arg Asp Ile Thr Ala Arg Phe Ser Gly Gln Gln Pro Thr Leu 
                85                  90                  95      


Pro Met Ala Asp Thr Val Asp Pro Leu Asp Trp Leu Phe Gly Glu Ser 
            100                 105                 110         


Gln Glu Lys Gln Pro Ser Gln Arg Asp Leu Pro Arg Arg Thr Gly Pro 
        115                 120                 125             


Ser Ala Gly Leu Trp Gly Pro His Arg Gln Met Asp Ser Ser Lys Pro 
    130                 135                 140                 


Met Gly Ala Pro Arg Gly Arg Leu Cys Glu Ala Arg Met Pro Gly His 
145                 150                 155                 160 


Ser Leu Ala Arg Pro Pro Gln Asp Gly Gln Gln Ser Ser Asp Leu Arg 
                165                 170                 175     


Ser Trp Thr Phe Gly Gln Ser Ala Gln Ala Met Ala Ser Arg His Arg 
            180                 185                 190         


Pro Arg Pro Ser Ser Val Leu Arg Thr Leu Tyr Ser His Leu Pro Val 
        195                 200                 205             


Ile His Glu Leu 
    210         


<210>  4171
<211>  326
<212>  PRT
<213>  Homo Sapiens

<400>  4171

Met Ser Glu Asn Asp Asn Val Phe Cys Ala Gln Leu Gln Cys Phe His 
1               5                   10                  15      


Phe Pro Thr Leu Arg His His Asp Leu His Ser Trp His Ala Glu Ser 
            20                  25                  30          


Cys Tyr Glu Lys Ser Ser Phe Leu Cys Lys Arg Ser Gln Thr Cys Val 
        35                  40                  45              


Asp Ile Lys Asp Asn Val Val Asp Glu Gly Phe Tyr Phe Thr Pro Lys 
    50                  55                  60                  


Gly Asp Asp Pro Cys Leu Ser Cys Thr Cys His Gly Gly Glu Pro Glu 
65                  70                  75                  80  


Met Cys Val Ala Ala Leu Cys Glu Arg Pro Gln Gly Cys Gln Gln Tyr 
                85                  90                  95      


Arg Lys Asp Pro Lys Glu Cys Cys Lys Phe Met Cys Leu Asp Pro Asp 
            100                 105                 110         


Gly Asn Ser Leu Phe Asp Ser Met Ala Ser Gly Met Arg Leu Val Val 
        115                 120                 125             


Ser Cys Ile Ser Ser Phe Leu Ile Leu Ser Leu Leu Leu Phe Met Val 
    130                 135                 140                 


His Arg Leu Arg Gln Arg Arg Arg Glu Arg Ile Glu Ser Leu Ile Gly 
145                 150                 155                 160 


Ala Asn Leu His His Phe Asn Leu Gly Arg Arg Ile Pro Gly Phe Asp 
                165                 170                 175     


Tyr Gly Pro Asp Gly Phe Gly Thr Gly Leu Thr Pro Leu His Leu Ser 
            180                 185                 190         


Asp Asp Gly Glu Gly Gly Thr Phe His Phe His Asp Pro Pro Pro Pro 
        195                 200                 205             


Tyr Thr Ala Tyr Lys Tyr Pro Asp Ile Gly Gln Pro Asp Asp Pro Pro 
    210                 215                 220                 


Pro Pro Tyr Glu Ala Ser Ile His Pro Asp Ser Val Phe Tyr Asp Pro 
225                 230                 235                 240 


Ala Asp Asp Asp Ala Phe Glu Pro Val Glu Val Ser Leu Pro Ala Pro 
                245                 250                 255     


Gly Asp Gly Gly Ser Glu Gly Ala Leu Leu Arg Arg Leu Glu Gln Pro 
            260                 265                 270         


Leu Pro Thr Ala Gly Ala Ser Leu Ala Asp Leu Glu Asp Ser Ala Asp 
        275                 280                 285             


Ser Ser Ser Ala Leu Leu Val Pro Pro Asp Pro Ala Gln Ser Gly Ser 
    290                 295                 300                 


Thr Pro Ala Ala Glu Ala Leu Pro Gly Gly Gly Arg His Ser Arg Ser 
305                 310                 315                 320 


Ser Leu Asn Thr Val Val 
                325     


<210>  4172
<211>  550
<212>  PRT
<213>  Homo Sapiens

<400>  4172

Met Val Pro Lys Ala Asp Ser Gly Ala Phe Leu Leu Leu Phe Leu Leu 
1               5                   10                  15      


Val Leu Thr Val Thr Glu Pro Leu Arg Pro Glu Leu Arg Cys Asn Pro 
            20                  25                  30          


Gly Gln Phe Ala Cys Arg Ser Gly Thr Ile Gln Cys Ile Pro Leu Pro 
        35                  40                  45              


Trp Gln Cys Asp Gly Trp Ala Thr Cys Glu Asp Glu Ser Asp Glu Ala 
    50                  55                  60                  


Asn Cys Pro Glu Val Thr Gly Glu Val Arg Pro His His Gly Lys Glu 
65                  70                  75                  80  


Ala Val Asp Pro Arg Gln Gly Arg Ala Arg Gly Gly Asp Pro Ser His 
                85                  90                  95      


Phe His Ala Val Asn Val Ala Gln Pro Val Arg Phe Ser Ser Phe Leu 
            100                 105                 110         


Gly Lys Cys Pro Thr Gly Trp His His Tyr Glu Gly Thr Ala Ser Cys 
        115                 120                 125             


Tyr Arg Val Tyr Leu Ser Gly Glu Asn Tyr Trp Asp Ala Ala Gln Thr 
    130                 135                 140                 


Cys Gln Arg Leu Asn Gly Ser Leu Ala Thr Phe Ser Thr Asp Gln Glu 
145                 150                 155                 160 


Leu Arg Phe Val Leu Ala Gln Glu Trp Asp Gln Pro Glu Arg Ser Phe 
                165                 170                 175     


Gly Trp Lys Asp Gln Arg Lys Leu Trp Val Gly Tyr Gln Tyr Val Ile 
            180                 185                 190         


Thr Gly Arg Asn Arg Ser Leu Glu Gly Arg Trp Glu Val Ala Phe Lys 
        195                 200                 205             


Gly Ser Ser Glu Val Phe Leu Pro Pro Asp Pro Ile Phe Ala Ser Ala 
    210                 215                 220                 


Met Ser Glu Asn Asp Asn Val Phe Cys Ala Gln Leu Gln Cys Phe His 
225                 230                 235                 240 


Phe Pro Thr Leu Arg His His Asp Leu His Ser Trp His Ala Glu Ser 
                245                 250                 255     


Cys Tyr Glu Lys Ser Ser Phe Leu Cys Lys Arg Ser Gln Thr Cys Val 
            260                 265                 270         


Asp Ile Lys Asp Asn Val Val Asp Glu Gly Phe Tyr Phe Thr Pro Lys 
        275                 280                 285             


Gly Asp Asp Pro Cys Leu Ser Cys Thr Cys His Gly Gly Glu Pro Glu 
    290                 295                 300                 


Met Cys Val Ala Ala Leu Cys Glu Arg Pro Gln Gly Cys Gln Gln Tyr 
305                 310                 315                 320 


Arg Lys Asp Pro Lys Glu Cys Cys Lys Phe Met Cys Leu Asp Pro Asp 
                325                 330                 335     


Gly Asn Ser Leu Phe Asp Ser Met Ala Ser Gly Met Arg Leu Val Val 
            340                 345                 350         


Ser Cys Ile Ser Ser Phe Leu Ile Leu Ser Leu Leu Leu Phe Met Val 
        355                 360                 365             


His Arg Leu Arg Gln Arg Arg Arg Glu Arg Ile Glu Ser Leu Ile Gly 
    370                 375                 380                 


Ala Asn Leu His His Phe Asn Leu Gly Arg Arg Ile Pro Gly Phe Asp 
385                 390                 395                 400 


Tyr Gly Pro Asp Gly Phe Gly Thr Gly Leu Thr Pro Leu His Leu Ser 
                405                 410                 415     


Asp Asp Gly Glu Gly Gly Thr Phe His Phe His Asp Pro Pro Pro Pro 
            420                 425                 430         


Tyr Thr Ala Tyr Lys Tyr Pro Asp Ile Gly Gln Pro Asp Asp Pro Pro 
        435                 440                 445             


Pro Pro Tyr Glu Ala Ser Ile His Pro Asp Ser Val Phe Tyr Asp Pro 
    450                 455                 460                 


Ala Asp Asp Asp Ala Phe Glu Pro Val Glu Val Ser Leu Pro Ala Pro 
465                 470                 475                 480 


Gly Asp Gly Gly Ser Glu Gly Ala Leu Leu Arg Arg Leu Glu Gln Pro 
                485                 490                 495     


Leu Pro Thr Ala Gly Ala Ser Leu Ala Asp Leu Glu Asp Ser Ala Asp 
            500                 505                 510         


Ser Ser Ser Ala Leu Leu Val Pro Pro Asp Pro Ala Gln Ser Gly Ser 
        515                 520                 525             


Thr Pro Ala Ala Glu Ala Leu Pro Gly Gly Gly Arg His Ser Arg Ser 
    530                 535                 540                 


Ser Leu Asn Thr Val Val 
545                 550 


<210>  4173
<211>  550
<212>  PRT
<213>  Homo Sapiens

<400>  4173

Met Val Pro Lys Ala Asp Ser Gly Ala Phe Leu Leu Leu Phe Leu Leu 
1               5                   10                  15      


Val Leu Thr Val Thr Glu Pro Leu Arg Pro Glu Leu Arg Cys Asn Pro 
            20                  25                  30          


Gly Gln Phe Ala Cys Arg Ser Gly Thr Ile Gln Cys Ile Pro Leu Pro 
        35                  40                  45              


Trp Gln Cys Asp Gly Trp Ala Thr Cys Glu Asp Glu Ser Asp Glu Ala 
    50                  55                  60                  


Asn Cys Pro Glu Val Thr Gly Glu Val Arg Pro His His Gly Lys Glu 
65                  70                  75                  80  


Ala Val Asp Pro Arg Gln Gly Arg Ala Arg Gly Gly Asp Pro Ser His 
                85                  90                  95      


Phe His Ala Val Asn Val Ala Gln Pro Val Arg Phe Ser Ser Asn Leu 
            100                 105                 110         


Arg Lys Cys Pro Thr Gly Trp His His Tyr Glu Gly Thr Ala Ser Cys 
        115                 120                 125             


Tyr Arg Val Tyr Leu Ser Gly Glu Asn Tyr Trp Asp Ala Ala Gln Thr 
    130                 135                 140                 


Cys Gln Arg Leu Asn Gly Ser Leu Ala Thr Phe Ser Thr Asp Gln Glu 
145                 150                 155                 160 


Leu Arg Phe Val Leu Ala Gln Glu Trp Asp Gln Pro Glu Arg Ser Phe 
                165                 170                 175     


Gly Trp Lys Asp Gln Arg Lys Leu Trp Val Gly Tyr Gln Tyr Val Ile 
            180                 185                 190         


Thr Gly Arg Asn Arg Ser Leu Glu Gly Arg Trp Glu Val Ala Phe Lys 
        195                 200                 205             


Gly Ser Ser Glu Val Phe Leu Pro Pro Asp Pro Ile Phe Ala Ser Ala 
    210                 215                 220                 


Met Ser Glu Asn Asp Asn Val Phe Cys Ala Gln Leu Gln Cys Phe His 
225                 230                 235                 240 


Phe Pro Thr Leu Arg His His Asp Leu His Ser Trp His Ala Glu Ser 
                245                 250                 255     


Cys Tyr Glu Lys Ser Ser Phe Leu Cys Lys Arg Ser Gln Thr Cys Val 
            260                 265                 270         


Asp Ile Lys Asp Asn Val Val Asp Glu Gly Phe Tyr Phe Thr Pro Lys 
        275                 280                 285             


Gly Asp Asp Pro Cys Leu Ser Cys Thr Cys His Gly Gly Glu Pro Glu 
    290                 295                 300                 


Met Cys Val Ala Ala Leu Cys Glu Arg Pro Gln Gly Cys Gln Gln Tyr 
305                 310                 315                 320 


Arg Lys Asp Pro Lys Glu Cys Cys Lys Phe Met Cys Leu Asp Pro Asp 
                325                 330                 335     


Gly Asn Ser Leu Phe Asp Ser Met Ala Ser Gly Met Arg Leu Val Val 
            340                 345                 350         


Ser Cys Ile Ser Ser Phe Leu Ile Leu Ser Leu Leu Leu Phe Met Val 
        355                 360                 365             


His Arg Leu Arg Gln Arg Arg Arg Glu Arg Ile Glu Ser Leu Ile Gly 
    370                 375                 380                 


Ala Asn Leu His His Phe Asn Leu Gly Arg Arg Ile Pro Gly Phe Asp 
385                 390                 395                 400 


Tyr Gly Pro Asp Gly Phe Gly Thr Gly Leu Thr Pro Leu His Leu Ser 
                405                 410                 415     


Asp Asp Gly Glu Gly Gly Thr Phe His Phe His Asp Pro Pro Pro Pro 
            420                 425                 430         


Tyr Thr Ala Tyr Lys Tyr Pro Asp Ile Gly Gln Pro Asp Asp Pro Pro 
        435                 440                 445             


Pro Pro Tyr Glu Ala Ser Ile His Pro Asp Ser Val Phe Tyr Asp Pro 
    450                 455                 460                 


Ala Asp Asp Asp Ala Phe Glu Pro Val Glu Val Ser Leu Pro Ala Pro 
465                 470                 475                 480 


Gly Asp Gly Gly Ser Glu Gly Ala Leu Leu Arg Arg Leu Glu Gln Pro 
                485                 490                 495     


Leu Pro Thr Ala Gly Ala Ser Leu Ala Asp Leu Glu Asp Ser Ala Asp 
            500                 505                 510         


Ser Ser Ser Ala Leu Leu Val Pro Pro Asp Pro Ala Gln Ser Gly Ser 
        515                 520                 525             


Thr Pro Ala Ala Glu Ala Leu Pro Gly Gly Gly Arg His Ser Arg Ser 
    530                 535                 540                 


Ser Leu Asn Thr Val Val 
545                 550 


<210>  4174
<211>  509
<212>  PRT
<213>  Homo Sapiens

<400>  4174

Met Val Pro Lys Ala Asp Ser Gly Ala Phe Leu Leu Leu Phe Leu Leu 
1               5                   10                  15      


Val Leu Thr Val Thr Glu Pro Leu Arg Pro Glu Val Thr Gly Glu Val 
            20                  25                  30          


Arg Pro His His Gly Lys Glu Ala Val Asp Pro Arg Gln Gly Arg Ala 
        35                  40                  45              


Arg Gly Gly Asp Pro Ser His Phe His Ala Val Asn Val Ala Gln Pro 
    50                  55                  60                  


Val Arg Phe Ser Ser Phe Leu Gly Lys Cys Pro Thr Gly Trp His His 
65                  70                  75                  80  


Tyr Glu Gly Thr Ala Ser Cys Tyr Arg Val Tyr Leu Ser Gly Glu Asn 
                85                  90                  95      


Tyr Trp Asp Ala Ala Gln Thr Cys Gln Arg Leu Asn Gly Ser Leu Ala 
            100                 105                 110         


Thr Phe Ser Thr Asp Gln Glu Leu Arg Phe Val Leu Ala Gln Glu Trp 
        115                 120                 125             


Asp Gln Pro Glu Arg Ser Phe Gly Trp Lys Asp Gln Arg Lys Leu Trp 
    130                 135                 140                 


Val Gly Tyr Gln Tyr Val Ile Thr Gly Arg Asn Arg Ser Leu Glu Gly 
145                 150                 155                 160 


Arg Trp Glu Val Ala Phe Lys Gly Ser Ser Glu Val Phe Leu Pro Pro 
                165                 170                 175     


Asp Pro Ile Phe Ala Ser Ala Met Ser Glu Asn Asp Asn Val Phe Cys 
            180                 185                 190         


Ala Gln Leu Gln Cys Phe His Phe Pro Thr Leu Arg His His Asp Leu 
        195                 200                 205             


His Ser Trp His Ala Glu Ser Cys Tyr Glu Lys Ser Ser Phe Leu Cys 
    210                 215                 220                 


Lys Arg Ser Gln Thr Cys Val Asp Ile Lys Asp Asn Val Val Asp Glu 
225                 230                 235                 240 


Gly Phe Tyr Phe Thr Pro Lys Gly Asp Asp Pro Cys Leu Ser Cys Thr 
                245                 250                 255     


Cys His Gly Gly Glu Pro Glu Met Cys Val Ala Ala Leu Cys Glu Arg 
            260                 265                 270         


Pro Gln Gly Cys Gln Gln Tyr Arg Lys Asp Pro Lys Glu Cys Cys Lys 
        275                 280                 285             


Phe Met Cys Leu Asp Pro Asp Gly Asn Ser Leu Phe Asp Ser Met Ala 
    290                 295                 300                 


Ser Gly Met Arg Leu Val Val Ser Cys Ile Ser Ser Phe Leu Ile Leu 
305                 310                 315                 320 


Ser Leu Leu Leu Phe Met Val His Arg Leu Arg Gln Arg Arg Arg Glu 
                325                 330                 335     


Arg Ile Glu Ser Leu Ile Gly Ala Asn Leu His His Phe Asn Leu Gly 
            340                 345                 350         


Arg Arg Ile Pro Gly Phe Asp Tyr Gly Pro Asp Gly Phe Gly Thr Gly 
        355                 360                 365             


Leu Thr Pro Leu His Leu Ser Asp Asp Gly Glu Gly Gly Thr Phe His 
    370                 375                 380                 


Phe His Asp Pro Pro Pro Pro Tyr Thr Ala Tyr Lys Tyr Pro Asp Ile 
385                 390                 395                 400 


Gly Gln Pro Asp Asp Pro Pro Pro Pro Tyr Glu Ala Ser Ile His Pro 
                405                 410                 415     


Asp Ser Val Phe Tyr Asp Pro Ala Asp Asp Asp Ala Phe Glu Pro Val 
            420                 425                 430         


Glu Val Ser Leu Pro Ala Pro Gly Asp Gly Gly Ser Glu Gly Ala Leu 
        435                 440                 445             


Leu Arg Arg Leu Glu Gln Pro Leu Pro Thr Ala Gly Ala Ser Leu Ala 
    450                 455                 460                 


Asp Leu Glu Asp Ser Ala Asp Ser Ser Ser Ala Leu Leu Val Pro Pro 
465                 470                 475                 480 


Asp Pro Ala Gln Ser Gly Ser Thr Pro Ala Ala Glu Ala Leu Pro Gly 
                485                 490                 495     


Gly Gly Arg His Ser Arg Ser Ser Leu Asn Thr Val Val 
            500                 505                 


<210>  4175
<211>  396
<212>  PRT
<213>  Homo Sapiens

<400>  4175

Met Ala Leu Leu Thr Asn Leu Leu Pro Leu Cys Cys Leu Ala Leu Leu 
1               5                   10                  15      


Ala Leu Pro Ala Gln Ser Cys Gly Pro Gly Arg Gly Pro Val Gly Arg 
            20                  25                  30          


Arg Arg Tyr Ala Arg Lys Gln Leu Val Pro Leu Leu Tyr Lys Gln Phe 
        35                  40                  45              


Val Pro Gly Val Pro Glu Arg Thr Leu Gly Ala Ser Gly Pro Ala Glu 
    50                  55                  60                  


Gly Arg Val Ala Arg Gly Ser Glu Arg Phe Arg Asp Leu Val Pro Asn 
65                  70                  75                  80  


Tyr Asn Pro Asp Ile Ile Phe Lys Asp Glu Glu Asn Ser Gly Ala Asp 
                85                  90                  95      


Arg Leu Met Thr Glu Arg Cys Lys Glu Arg Val Asn Ala Leu Ala Ile 
            100                 105                 110         


Ala Val Met Asn Met Trp Pro Gly Val Arg Leu Arg Val Thr Glu Gly 
        115                 120                 125             


Trp Asp Glu Asp Gly His His Ala Gln Asp Ser Leu His Tyr Glu Gly 
    130                 135                 140                 


Arg Ala Leu Asp Ile Thr Thr Ser Asp Arg Asp Arg Asn Lys Tyr Gly 
145                 150                 155                 160 


Leu Leu Ala Arg Leu Ala Val Glu Ala Gly Phe Asp Trp Val Tyr Tyr 
                165                 170                 175     


Glu Ser Arg Asn His Val His Val Ser Val Lys Ala Asp Asn Ser Leu 
            180                 185                 190         


Ala Val Arg Ala Gly Gly Cys Phe Pro Gly Asn Ala Thr Val Arg Leu 
        195                 200                 205             


Trp Ser Gly Glu Arg Lys Gly Leu Arg Glu Leu His Arg Gly Asp Trp 
    210                 215                 220                 


Val Leu Ala Ala Asp Ala Ser Gly Arg Val Val Pro Thr Pro Val Leu 
225                 230                 235                 240 


Leu Phe Leu Asp Arg Asp Leu Gln Arg Arg Ala Ser Phe Val Ala Val 
                245                 250                 255     


Glu Thr Glu Trp Pro Pro Arg Lys Leu Leu Leu Thr Pro Trp His Leu 
            260                 265                 270         


Val Phe Ala Ala Arg Gly Pro Ala Pro Ala Pro Gly Asp Phe Ala Pro 
        275                 280                 285             


Val Phe Ala Arg Arg Leu Arg Ala Gly Asp Ser Val Leu Ala Pro Gly 
    290                 295                 300                 


Gly Asp Ala Leu Arg Pro Ala Arg Val Ala Arg Val Ala Arg Glu Glu 
305                 310                 315                 320 


Ala Val Gly Val Phe Ala Pro Leu Thr Ala His Gly Thr Leu Leu Val 
                325                 330                 335     


Asn Asp Val Leu Ala Ser Cys Tyr Ala Val Leu Glu Ser His Gln Trp 
            340                 345                 350         


Ala His Arg Ala Phe Ala Pro Leu Arg Leu Leu His Ala Leu Gly Ala 
        355                 360                 365             


Leu Leu Pro Gly Gly Ala Val Gln Pro Thr Gly Met His Trp Tyr Ser 
    370                 375                 380                 


Arg Leu Leu Tyr Arg Leu Ala Glu Glu Leu Leu Gly 
385                 390                 395     


<210>  4176
<211>  155
<212>  PRT
<213>  Homo Sapiens

<400>  4176

Met His Lys Ala Gly Leu Leu Gly Leu Cys Ala Arg Ala Trp Asn Ser 
1               5                   10                  15      


Val Arg Met Ala Ser Ser Gly Met Thr Arg Arg Asp Pro Leu Ala Asn 
            20                  25                  30          


Lys Val Ala Leu Val Thr Ala Ser Thr Asp Gly Ile Gly Phe Ala Ile 
        35                  40                  45              


Ala Arg Arg Leu Ala Gln Asp Gly Ala His Val Val Val Ser Ser Arg 
    50                  55                  60                  


Lys Gln Gln Asn Val Asp Gln Ala Val Ala Thr Leu Gln Gly Glu Gly 
65                  70                  75                  80  


Leu Ser Val Thr Gly Thr Val Cys His Val Gly Lys Ala Glu Asp Arg 
                85                  90                  95      


Glu Arg Leu Val Ala Thr Ala Val Lys Leu His Gly Gly Ile Asp Ile 
            100                 105                 110         


Leu Val Ser Asn Ala Ala Val Asn Pro Phe Phe Gly Ser Ile Met Asp 
        115                 120                 125             


Val Thr Glu Glu Val Trp Asp Lys Leu Trp Met Asp Lys Glu Lys Glu 
    130                 135                 140                 


Glu Ser Met Lys Glu Thr Leu Arg Ile Arg Arg 
145                 150                 155 


<210>  4177
<211>  192
<212>  PRT
<213>  Homo Sapiens

<400>  4177

Met His Lys Ala Gly Leu Leu Gly Leu Cys Ala Arg Ala Trp Asn Ser 
1               5                   10                  15      


Val Arg Met Ala Ser Ser Gly Met Thr Arg Arg Asp Pro Leu Ala Asn 
            20                  25                  30          


Lys Val Ala Leu Val Thr Ala Ser Thr Asp Gly Ile Gly Phe Ala Ile 
        35                  40                  45              


Ala Arg Arg Leu Ala Gln Asp Gly Ala His Val Val Val Ser Ser Arg 
    50                  55                  60                  


Lys Gln Gln Asn Val Asp Gln Ala Val Ala Thr Leu Gln Gly Glu Gly 
65                  70                  75                  80  


Leu Ser Val Thr Gly Thr Val Cys His Val Gly Lys Ala Glu Asp Arg 
                85                  90                  95      


Glu Arg Leu Val Ala Thr Ala Val Lys Leu His Gly Gly Ile Asp Ile 
            100                 105                 110         


Leu Val Ser Asn Ala Ala Val Asn Pro Phe Phe Gly Ser Ile Met Asp 
        115                 120                 125             


Val Thr Glu Glu Val Trp Asp Lys Leu Trp Met Asp Lys Glu Lys Glu 
    130                 135                 140                 


Glu Ser Met Lys Glu Thr Leu Arg Ile Arg Arg Leu Gly Glu Pro Glu 
145                 150                 155                 160 


Asp Cys Ala Gly Ile Val Ser Phe Leu Cys Ser Glu Asp Ala Ser Tyr 
                165                 170                 175     


Ile Thr Gly Glu Thr Val Val Val Gly Gly Gly Thr Pro Ser Arg Leu 
            180                 185                 190         


<210>  4178
<211>  188
<212>  PRT
<213>  Homo Sapiens

<400>  4178

Met His Lys Ala Gly Leu Leu Gly Leu Cys Ala Arg Ala Trp Asn Ser 
1               5                   10                  15      


Val Arg Met Ala Ser Ser Gly Met Thr Arg Arg Asp Pro Leu Ala Asn 
            20                  25                  30          


Lys Val Ala Leu Val Thr Ala Ser Thr Asp Gly Ile Gly Phe Ala Ile 
        35                  40                  45              


Ala Arg Arg Leu Ala Gln Asp Gly Ala His Val Val Val Ser Ser Arg 
    50                  55                  60                  


Lys Gln Gln Asn Val Asp Gln Ala Val Ala Thr Leu Gln Gly Glu Gly 
65                  70                  75                  80  


Leu Ser Val Thr Gly Thr Val Cys His Val Gly Lys Ala Glu Asp Arg 
                85                  90                  95      


Glu Arg Leu Val Ala Thr Ala Val Lys Leu His Gly Gly Ile Asp Ile 
            100                 105                 110         


Leu Val Ser Asn Ala Ala Val Asn Pro Phe Phe Gly Ser Ile Met Asp 
        115                 120                 125             


Val Thr Glu Glu Val Trp Asp Lys Arg Arg Leu Ser Gly Asp Arg Val 
    130                 135                 140                 


Phe His Ser Ser Leu Gln Ser Ile Ser Ser Leu Asp Gly Gln Gly Lys 
145                 150                 155                 160 


Arg Gly Lys His Glu Arg Asn Pro Ala Asp Lys Lys Val Arg Arg Ala 
                165                 170                 175     


Arg Gly Leu Cys Trp His Arg Val Phe Pro Val Leu 
            180                 185             


<210>  4179
<211>  278
<212>  PRT
<213>  Homo Sapiens

<400>  4179

Met His Lys Ala Gly Leu Leu Gly Leu Cys Ala Arg Ala Trp Asn Ser 
1               5                   10                  15      


Val Arg Met Ala Ser Ser Gly Met Thr Arg Arg Asp Pro Leu Ala Asn 
            20                  25                  30          


Lys Val Ala Leu Val Thr Ala Ser Thr Asp Gly Ile Gly Phe Ala Ile 
        35                  40                  45              


Ala Arg Arg Leu Ala Gln Asp Gly Ala His Val Val Val Ser Ser Arg 
    50                  55                  60                  


Lys Gln Gln Asn Val Asp Gln Ala Val Ala Thr Leu Gln Gly Glu Gly 
65                  70                  75                  80  


Leu Ser Val Thr Gly Thr Val Cys His Val Gly Lys Ala Glu Asp Arg 
                85                  90                  95      


Glu Arg Leu Val Ala Thr Ala Val Lys Leu His Gly Gly Ile Asp Ile 
            100                 105                 110         


Leu Val Ser Asn Ala Ala Val Asn Pro Phe Phe Gly Ser Ile Met Asp 
        115                 120                 125             


Val Thr Glu Glu Val Trp Asp Lys Thr Leu Asp Ile Asn Val Lys Ala 
    130                 135                 140                 


Pro Ala Leu Met Thr Lys Ala Val Val Pro Glu Met Glu Lys Arg Gly 
145                 150                 155                 160 


Gly Gly Ser Val Val Ile Val Ser Ser Ile Ala Ala Phe Ser Pro Ser 
                165                 170                 175     


Pro Gly Phe Ser Pro Tyr Asn Val Ser Lys Thr Ala Leu Leu Gly Leu 
            180                 185                 190         


Thr Lys Thr Leu Ala Ile Glu Leu Ala Pro Arg Asn Ile Arg Val Asn 
        195                 200                 205             


Cys Leu Ala Pro Gly Leu Ile Lys Thr Ser Phe Ser Arg Met Leu Trp 
    210                 215                 220                 


Met Asp Lys Glu Lys Glu Glu Ser Met Lys Glu Thr Leu Arg Ile Arg 
225                 230                 235                 240 


Arg Leu Gly Glu Pro Glu Asp Cys Ala Gly Ile Val Ser Phe Leu Cys 
                245                 250                 255     


Ser Glu Asp Ala Ser Tyr Ile Thr Gly Glu Thr Val Val Val Gly Gly 
            260                 265                 270         


Gly Thr Pro Ser Arg Leu 
        275             


<210>  4180
<211>  158
<212>  PRT
<213>  Homo Sapiens

<400>  4180

Met His Lys Ala Gly Leu Leu Gly Leu Cys Ala Arg Ala Trp Asn Ser 
1               5                   10                  15      


Val Arg Met Ala Ser Ser Gly Met Thr Arg Arg Asp Pro Leu Ala Asn 
            20                  25                  30          


Lys Val Ala Leu Val Thr Ala Ser Thr Asp Gly Ile Gly Phe Ala Ile 
        35                  40                  45              


Ala Arg Arg Leu Ala Gln Asp Gly Ala His Val Val Val Ser Ser Arg 
    50                  55                  60                  


Lys Gln Gln Asn Val Asp Gln Ala Val Ala Thr Leu Gln Gly Glu Gly 
65                  70                  75                  80  


Leu Ser Val Thr Gly Thr Val Cys His Val Gly Lys Ala Glu Asp Arg 
                85                  90                  95      


Glu Arg Leu Val Ala Thr Leu Trp Met Asp Lys Glu Lys Glu Glu Ser 
            100                 105                 110         


Met Lys Glu Thr Leu Arg Ile Arg Arg Leu Gly Glu Pro Glu Asp Cys 
        115                 120                 125             


Ala Gly Ile Val Ser Phe Leu Cys Ser Glu Asp Ala Ser Tyr Ile Thr 
    130                 135                 140                 


Gly Glu Thr Val Val Val Gly Gly Gly Thr Pro Ser Arg Leu 
145                 150                 155             


<210>  4181
<211>  244
<212>  PRT
<213>  Homo Sapiens

<400>  4181

Met His Lys Ala Gly Leu Leu Gly Leu Cys Ala Arg Ala Trp Asn Ser 
1               5                   10                  15      


Val Arg Met Ala Ser Ser Gly Met Thr Arg Arg Asp Pro Leu Ala Asn 
            20                  25                  30          


Lys Val Ala Leu Val Thr Ala Ser Thr Asp Gly Ile Gly Phe Ala Ile 
        35                  40                  45              


Ala Arg Arg Leu Ala Gln Asp Gly Ala His Val Val Val Ser Ser Arg 
    50                  55                  60                  


Lys Gln Gln Asn Val Asp Gln Ala Val Ala Thr Leu Gln Gly Glu Gly 
65                  70                  75                  80  


Leu Ser Val Thr Gly Thr Val Cys His Val Gly Lys Ala Glu Asp Arg 
                85                  90                  95      


Glu Arg Leu Val Ala Thr Thr Leu Asp Ile Asn Val Lys Ala Pro Ala 
            100                 105                 110         


Leu Met Thr Lys Ala Val Val Pro Glu Met Glu Lys Arg Gly Gly Gly 
        115                 120                 125             


Ser Val Val Ile Val Ser Ser Ile Ala Ala Phe Ser Pro Ser Pro Gly 
    130                 135                 140                 


Phe Ser Pro Tyr Asn Val Ser Lys Thr Ala Leu Leu Gly Leu Thr Lys 
145                 150                 155                 160 


Thr Leu Ala Ile Glu Leu Ala Pro Arg Asn Ile Arg Val Asn Cys Leu 
                165                 170                 175     


Ala Pro Gly Leu Ile Lys Thr Ser Phe Ser Arg Met Leu Trp Met Asp 
            180                 185                 190         


Lys Glu Lys Glu Glu Ser Met Lys Glu Thr Leu Arg Ile Arg Arg Leu 
        195                 200                 205             


Gly Glu Pro Glu Asp Cys Ala Gly Ile Val Ser Phe Leu Cys Ser Glu 
    210                 215                 220                 


Asp Ala Ser Tyr Ile Thr Gly Glu Thr Val Val Val Gly Gly Gly Thr 
225                 230                 235                 240 


Pro Ser Arg Leu 
                


<210>  4182
<211>  199
<212>  PRT
<213>  Homo Sapiens

<400>  4182

Met His Lys Ala Gly Leu Leu Gly Leu Cys Ala Arg Ala Trp Asn Ser 
1               5                   10                  15      


Val Arg Met Ala Ser Ser Gly Met Thr Arg Arg Asp Pro Leu Ala Asn 
            20                  25                  30          


Lys Val Ala Leu Val Thr Ala Ser Thr Asp Gly Ile Gly Phe Ala Ile 
        35                  40                  45              


Ala Arg Arg Leu Ala Gln Asp Gly Ala His Val Val Val Ser Ser Arg 
    50                  55                  60                  


Lys Gln Gln Asn Val Asp Gln Ala Val Ala Thr Leu Gln Gly Glu Gly 
65                  70                  75                  80  


Leu Ser Val Thr Gly Thr Val Cys His Val Gly Lys Ala Glu Asp Arg 
                85                  90                  95      


Glu Arg Leu Val Ala Thr Thr Leu Asp Ile Asn Val Lys Ala Pro Ala 
            100                 105                 110         


Leu Met Thr Lys Ala Val Val Pro Glu Met Glu Lys Arg Gly Gly Gly 
        115                 120                 125             


Ser Val Val Ile Val Ser Ser Ile Ala Ala Phe Ser Pro Ser Pro Leu 
    130                 135                 140                 


Trp Met Asp Lys Glu Lys Glu Glu Ser Met Lys Glu Thr Leu Arg Ile 
145                 150                 155                 160 


Arg Arg Leu Gly Glu Pro Glu Asp Cys Ala Gly Ile Val Ser Phe Leu 
                165                 170                 175     


Cys Ser Glu Asp Ala Ser Tyr Ile Thr Gly Glu Thr Val Val Val Gly 
            180                 185                 190         


Gly Gly Thr Pro Ser Arg Leu 
        195                 


<210>  4183
<211>  61
<212>  PRT
<213>  Homo Sapiens

<400>  4183

Arg Asn Ile Arg Val Asn Cys Leu Ala Pro Gly Leu Ile Lys Thr Ser 
1               5                   10                  15      


Phe Ser Arg Met Leu Trp Met Asp Lys Glu Lys Glu Glu Ser Met Lys 
            20                  25                  30          


Glu Thr Leu Arg Ile Arg Arg Pro Arg Ile His Lys His Tyr His Tyr 
        35                  40                  45              


Ser Asp Leu Ser Lys Lys Ser Ala Ser Leu Ser Lys Gly 
    50                  55                  60      


<210>  4184
<211>  90
<212>  PRT
<213>  Homo Sapiens

<400>  4184

Met Ala Val Lys Leu His Gly Gly Ile Asp Ile Leu Val Ser Asn Ala 
1               5                   10                  15      


Ala Val Asn Pro Phe Phe Gly Ser Leu Met Asp Val Thr Glu Glu Val 
            20                  25                  30          


Trp Asp Lys Gly Phe Ser Pro Tyr Asn Val Ser Lys Thr Ala Leu Leu 
        35                  40                  45              


Gly Leu Asn Asn Thr Leu Ala Ile Glu Leu Ala Pro Arg Asn Ile Arg 
    50                  55                  60                  


Val Asn Cys Leu His Leu Asp Leu Ser Arg Leu Ala Ser Ala Gly Cys 
65                  70                  75                  80  


Ser Gly Trp Thr Arg Lys Lys Arg Lys Ala 
                85                  90  


<210>  4185
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  4185

Met Ala Val Lys Leu His Gly Gly Ile Asp Ile Leu Val Ser Asn Ala 
1               5                   10                  15      


Ala Val Asn Pro Phe Phe Gly Ser Leu Met Asp Val Thr Glu Glu Val 
            20                  25                  30          


Trp Asp Lys Thr Leu Asp Ile Asn Val Lys Ala Pro Ala Leu Met Thr 
        35                  40                  45              


Lys Ala Val Val Pro Glu Met Glu Lys Arg Gly Gly Gly Ser Val Val 
    50                  55                  60                  


Ile Val Ser Ser Ile Ala Ala Phe Ser Pro Ser Pro Gly Phe Ser Pro 
65                  70                  75                  80  


Tyr Asn Val Ser Lys Thr Ala Leu Leu Gly Leu Asn Asn Thr Leu Ala 
                85                  90                  95      


Ile Glu Leu Ala Pro Arg Asn Ile Arg Val Asn Cys Leu His Leu Asp 
            100                 105                 110         


Leu Ser Arg Leu Ala Ser Ala Gly Cys Ser Gly Trp Thr Arg Lys Lys 
        115                 120                 125             


Arg Lys Ala 
    130     


<210>  4186
<211>  49
<212>  PRT
<213>  Homo Sapiens

<400>  4186

Met Asp Val Thr Glu Glu Val Trp Asp Lys Thr Leu Asp Ile Asn Val 
1               5                   10                  15      


Lys Ala Pro Ala Leu Met Thr Lys Ala Val Val Pro Glu Met Glu Lys 
            20                  25                  30          


Arg Gly Gly Gly Ser Val Val Ile Val Ser Ser Ile Ala Ala Phe Ser 
        35                  40                  45              


Pro 
    


<210>  4187
<211>  215
<212>  PRT
<213>  Homo Sapiens

<400>  4187

Met Pro Phe Pro Cys Leu Ser Leu Pro Ser Ser Trp Asp Tyr Arg Ile 
1               5                   10                  15      


Gly Phe Ala Ile Ala Arg Arg Leu Ala Gln Asp Arg Ala His Val Val 
            20                  25                  30          


Val Ser Ser Arg Lys Gln Gln Asn Val Asp Gln Ala Val Ala Thr Leu 
        35                  40                  45              


Gln Gly Glu Gly Leu Ser Val Thr Gly Thr Val Cys His Val Gly Lys 
    50                  55                  60                  


Ala Glu Asp Arg Glu Arg Leu Val Ala Met Thr Leu Asp Ile Asn Val 
65                  70                  75                  80  


Lys Ala Pro Ala Leu Met Thr Lys Ala Val Val Pro Glu Met Glu Lys 
                85                  90                  95      


Arg Gly Gly Gly Ser Val Val Ile Val Ser Ser Ile Ala Ala Phe Ser 
            100                 105                 110         


Pro Ser Pro Gly Phe Ser Pro Tyr Asn Val Ser Lys Thr Ala Leu Leu 
        115                 120                 125             


Gly Leu Asn Asn Thr Leu Ala Ile Glu Leu Ala Pro Arg Asn Ile Arg 
    130                 135                 140                 


Val Asn Cys Leu Pro Gly Leu Ile Lys Thr Ser Phe Ser Arg Met Leu 
145                 150                 155                 160 


Trp Met Asp Lys Glu Lys Glu Glu Ser Met Lys Glu Thr Leu Arg Ile 
                165                 170                 175     


Arg Arg Leu Gly Glu Pro Glu Asp Cys Ala Gly Ile Val Ser Phe Leu 
            180                 185                 190         


Cys Ser Glu Asp Ala Ser Tyr Ile Thr Gly Glu Thr Val Val Val Gly 
        195                 200                 205             


Gly Gly Thr Pro Ser Arg Leu 
    210                 215 


<210>  4188
<211>  192
<212>  PRT
<213>  Homo Sapiens

<400>  4188

Met Gln Met Ala Arg Leu Leu Gly Leu Cys Ala Trp Ala Arg Lys Ser 
1               5                   10                  15      


Val Arg Met Ala Ser Ser Arg Met Thr Arg Arg Asp Pro Leu Thr Asn 
            20                  25                  30          


Lys Val Ala Leu Val Thr Ala Ser Thr Asp Gly Ile Gly Phe Ala Ile 
        35                  40                  45              


Ala Arg Arg Leu Ala Gln Asp Arg Ala His Val Val Val Ser Ser Arg 
    50                  55                  60                  


Lys Gln Gln Asn Val Asp Gln Ala Val Ala Thr Leu Gln Gly Glu Gly 
65                  70                  75                  80  


Leu Ser Val Thr Gly Thr Val Cys His Val Gly Lys Ala Glu Asp Arg 
                85                  90                  95      


Glu Arg Leu Val Ala Met Ala Val Lys Leu His Gly Gly Ile Asp Ile 
            100                 105                 110         


Leu Val Ser Asn Ala Ala Val Asn Pro Phe Phe Gly Ser Leu Met Asp 
        115                 120                 125             


Val Thr Glu Glu Val Trp Asp Lys Leu Trp Met Asp Lys Glu Lys Glu 
    130                 135                 140                 


Glu Ser Met Lys Glu Thr Leu Arg Ile Arg Arg Leu Gly Glu Pro Glu 
145                 150                 155                 160 


Asp Cys Ala Gly Ile Val Ser Phe Leu Cys Ser Glu Asp Ala Ser Tyr 
                165                 170                 175     


Ile Thr Gly Glu Thr Val Val Val Gly Gly Gly Thr Pro Ser Arg Leu 
            180                 185                 190         


<210>  4189
<211>  232
<212>  PRT
<213>  Homo Sapiens

<400>  4189

Met Gln Met Ala Arg Leu Leu Gly Leu Cys Ala Trp Ala Arg Lys Ser 
1               5                   10                  15      


Val Arg Met Ala Ser Ser Arg Met Thr Arg Arg Asp Pro Leu Thr Asn 
            20                  25                  30          


Lys Val Ala Leu Val Thr Ala Ser Thr Asp Gly Ile Gly Phe Ala Ile 
        35                  40                  45              


Ala Arg Arg Leu Ala Gln Asp Arg Ala His Val Val Val Ser Ser Arg 
    50                  55                  60                  


Lys Gln Gln Asn Val Asp Gln Ala Val Ala Thr Leu Gln Gly Glu Gly 
65                  70                  75                  80  


Leu Ser Val Thr Gly Thr Val Cys His Val Gly Lys Ala Glu Asp Arg 
                85                  90                  95      


Glu Arg Leu Val Ala Met Ala Val Lys Leu His Gly Gly Ile Asp Ile 
            100                 105                 110         


Leu Val Ser Asn Ala Ala Val Asn Pro Phe Phe Gly Ser Leu Met Asp 
        115                 120                 125             


Val Thr Glu Glu Val Trp Asp Lys Thr Leu Asp Ile Asn Val Lys Ala 
    130                 135                 140                 


Pro Ala Leu Met Thr Lys Ala Val Val Pro Glu Met Glu Lys Arg Gly 
145                 150                 155                 160 


Gly Gly Ser Val Val Ile Val Ser Ser Ile Ala Ala Phe Ser Pro Ser 
                165                 170                 175     


Pro Gly Phe Ser Pro Tyr Asn Val Ser Lys Thr Ala Leu Leu Gly Leu 
            180                 185                 190         


Asn Asn Thr Leu Ala Ile Glu Leu Ala Pro Arg Asn Ile Arg Val Asn 
        195                 200                 205             


Cys Leu His Leu Asp Leu Ser Arg Leu Ala Ser Ala Gly Cys Ser Gly 
    210                 215                 220                 


Trp Thr Arg Lys Lys Arg Lys Ala 
225                 230         


<210>  4190
<211>  242
<212>  PRT
<213>  Homo Sapiens

<400>  4190

Met Gln Met Ala Arg Leu Leu Gly Leu Cys Ala Trp Ala Arg Lys Ser 
1               5                   10                  15      


Val Arg Met Ala Ser Ser Arg Met Thr Arg Arg Asp Pro Leu Thr Asn 
            20                  25                  30          


Lys Val Ala Leu Val Thr Ala Ser Thr Asp Gly Ile Gly Phe Ala Ile 
        35                  40                  45              


Ala Arg Arg Leu Ala Gln Asp Arg Ala His Val Val Val Ser Ser Arg 
    50                  55                  60                  


Lys Gln Gln Asn Val Asp Gln Ala Val Ala Thr Leu Gln Gly Glu Gly 
65                  70                  75                  80  


Leu Ser Val Thr Gly Thr Val Cys His Val Gly Lys Ala Glu Asp Arg 
                85                  90                  95      


Glu Arg Leu Val Ala Met Ala Val Lys Leu His Gly Gly Ile Asp Ile 
            100                 105                 110         


Leu Val Ser Asn Ala Ala Val Asn Pro Phe Phe Gly Ser Leu Met Asp 
        115                 120                 125             


Val Thr Glu Glu Val Trp Asp Lys Thr Leu Asp Ile Asn Val Lys Ala 
    130                 135                 140                 


Pro Ala Leu Met Thr Lys Ala Val Val Pro Glu Met Glu Lys Arg Gly 
145                 150                 155                 160 


Gly Gly Ser Val Val Ile Val Ser Ser Ile Ala Ala Phe Ser Pro Ser 
                165                 170                 175     


Pro Gly Phe Ser Pro Tyr Asn Val Ser Lys Thr Ala Leu Leu Gly Leu 
            180                 185                 190         


Asn Asn Thr Leu Ala Ile Glu Leu Ala Pro Arg Asn Ile Arg Val Asn 
        195                 200                 205             


Cys Leu His Leu Asp Leu Ser Arg Leu Ala Ser Ala Gly Trp Leu Gly 
    210                 215                 220                 


Glu Pro Glu Asp Cys Ala Gly Ile Val Ser Phe Leu Cys Ser Glu Asp 
225                 230                 235                 240 


Ala Ser 
        


<210>  4191
<211>  157
<212>  PRT
<213>  Homo Sapiens

<400>  4191

Met Gln Met Ala Arg Leu Leu Gly Leu Cys Ala Trp Ala Arg Lys Ser 
1               5                   10                  15      


Val Arg Met Ala Ser Ser Arg Met Thr Arg Arg Asp Pro Leu Thr Asn 
            20                  25                  30          


Lys Val Ala Leu Val Thr Ala Ser Thr Asp Gly Ile Gly Phe Ala Ile 
        35                  40                  45              


Ala Arg Arg Leu Ala Gln Asp Arg Ala His Val Val Val Ser Ser Arg 
    50                  55                  60                  


Lys Gln Gln Asn Val Asp Gln Ala Val Ala Thr Leu Gln Gly Glu Gly 
65                  70                  75                  80  


Leu Ser Val Thr Gly Thr Val Cys His Val Gly Lys Ala Glu Asp Arg 
                85                  90                  95      


Glu Arg Leu Val Ala Met Gly Phe Ser Pro Tyr Asn Val Ser Lys Thr 
            100                 105                 110         


Ala Leu Leu Gly Leu Asn Asn Thr Leu Ala Ile Glu Leu Ala Pro Arg 
        115                 120                 125             


Asn Ile Arg Val Asn Cys Leu His Leu Asp Leu Ser Arg Leu Ala Ser 
    130                 135                 140                 


Ala Gly Cys Ser Gly Trp Thr Arg Lys Lys Arg Lys Ala 
145                 150                 155         


<210>  4192
<211>  157
<212>  PRT
<213>  Homo Sapiens

<400>  4192

Met Gln Met Ala Arg Leu Leu Gly Leu Cys Ala Trp Ala Arg Lys Ser 
1               5                   10                  15      


Val Arg Met Ala Ser Ser Arg Met Thr Arg Arg Asp Pro Leu Thr Asn 
            20                  25                  30          


Lys Val Ala Leu Val Thr Ala Ser Thr Asp Gly Ile Gly Phe Ala Ile 
        35                  40                  45              


Ala Arg Arg Leu Ala Gln Asp Arg Ala His Val Val Val Ser Ser Arg 
    50                  55                  60                  


Lys Gln Gln Asn Val Asp Gln Ala Val Ala Thr Leu Gln Gly Glu Gly 
65                  70                  75                  80  


Leu Ser Val Thr Gly Thr Val Cys His Val Gly Lys Ala Glu Asp Arg 
                85                  90                  95      


Glu Arg Leu Val Ala Met Gly Phe Ser Pro Tyr Asn Val Ser Lys Thr 
            100                 105                 110         


Ala Leu Leu Gly Leu Asn Asn Thr Leu Ala Ile Glu Leu Ala Pro Arg 
        115                 120                 125             


Asn Ile Arg Val Asn Cys Leu His Leu Asp Leu Ser Arg Leu Ala Ser 
    130                 135                 140                 


Ala Gly Cys Ser Gly Trp Thr Arg Lys Lys Arg Lys Ala 
145                 150                 155         


<210>  4193
<211>  109
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4193

Xaa Ser Leu Met Asp Val Thr Glu Glu Val Trp Asp Lys Thr Leu Asp 
1               5                   10                  15      


Ile Asn Val Lys Ala Pro Ala Leu Met Thr Lys Ala Val Val Pro Glu 
            20                  25                  30          


Met Glu Lys Arg Gly Gly Gly Ser Val Val Ile Val Ser Ser Ile Ala 
        35                  40                  45              


Ala Phe Ser Pro Ser Pro Gly Phe Ser Pro Tyr Asn Val Ser Lys Thr 
    50                  55                  60                  


Ala Leu Leu Gly Leu Asn Asn Thr Leu Ala Ile Glu Leu Ala Pro Arg 
65                  70                  75                  80  


Asn Ile Arg Val Asn Cys Leu His Leu Asp Leu Ser Arg Leu Ala Ser 
                85                  90                  95      


Ala Gly Cys Ser Gly Trp Thr Arg Lys Lys Arg Lys Ala 
            100                 105                 


<210>  4194
<211>  61
<212>  PRT
<213>  Homo Sapiens

<400>  4194

Met Asn Trp Glu Leu Leu Leu Trp Leu Leu Val Leu Cys Ala Leu Leu 
1               5                   10                  15      


Leu Leu Leu Val Gln Leu Leu Arg Phe Leu Arg Ala Asp Gly Asp Leu 
            20                  25                  30          


Thr Leu Leu Trp Ala Glu Trp Gln Gly Arg Arg Pro Glu Trp Glu Leu 
        35                  40                  45              


Thr Asp Met Val Val Trp Val Thr Gly Ala Ser Ser Gly 
    50                  55                  60      


<210>  4195
<211>  339
<212>  PRT
<213>  Homo Sapiens

<400>  4195

Met Asn Trp Glu Leu Leu Leu Trp Leu Leu Val Leu Cys Ala Leu Leu 
1               5                   10                  15      


Leu Leu Leu Val Gln Leu Leu Arg Phe Leu Arg Ala Asp Gly Asp Leu 
            20                  25                  30          


Thr Leu Leu Trp Ala Glu Trp Gln Gly Arg Arg Pro Glu Trp Glu Leu 
        35                  40                  45              


Thr Asp Met Val Val Trp Val Thr Gly Ala Ser Ser Gly Ile Gly Glu 
    50                  55                  60                  


Glu Leu Ala Tyr Gln Leu Ser Lys Leu Gly Val Ser Leu Val Leu Ser 
65                  70                  75                  80  


Ala Arg Arg Val His Glu Leu Glu Arg Val Lys Arg Arg Cys Leu Glu 
                85                  90                  95      


Asn Gly Asn Leu Lys Glu Lys Asp Ile Leu Val Leu Pro Leu Asp Leu 
            100                 105                 110         


Thr Asp Thr Gly Ser His Glu Ala Ala Thr Lys Ala Val Leu Gln Glu 
        115                 120                 125             


Phe Gly Arg Ile Asp Ile Leu Val Asn Asn Gly Gly Met Ser Gln Arg 
    130                 135                 140                 


Ser Leu Cys Met Asp Thr Ser Leu Asp Val Tyr Arg Lys Leu Ile Glu 
145                 150                 155                 160 


Leu Asn Tyr Leu Gly Thr Val Ser Leu Thr Lys Cys Val Leu Pro His 
                165                 170                 175     


Met Ile Glu Arg Lys Gln Gly Lys Ile Val Thr Val Asn Ser Ile Leu 
            180                 185                 190         


Gly Ile Ile Ser Val Pro Leu Ser Ile Gly Tyr Cys Ala Ser Lys His 
        195                 200                 205             


Ala Leu Arg Gly Phe Phe Asn Gly Leu Arg Thr Glu Leu Ala Thr Tyr 
    210                 215                 220                 


Pro Gly Ile Ile Val Ser Asn Ile Cys Pro Gly Pro Val Gln Ser Asn 
225                 230                 235                 240 


Ile Val Glu Asn Ser Leu Ala Gly Glu Val Thr Lys Thr Ile Gly Asn 
                245                 250                 255     


Asn Gly Asp Gln Ser His Lys Met Thr Thr Ser Arg Cys Val Arg Leu 
            260                 265                 270         


Met Leu Ile Ser Met Ala Asn Asp Leu Lys Glu Val Trp Ile Ser Glu 
        275                 280                 285             


Gln Pro Phe Leu Leu Val Thr Tyr Leu Trp Gln Tyr Met Pro Thr Trp 
    290                 295                 300                 


Ala Trp Trp Ile Thr Asn Lys Met Gly Lys Lys Arg Ile Glu Asn Phe 
305                 310                 315                 320 


Lys Ser Gly Val Asp Ala Asp Ser Ser Tyr Phe Lys Ile Phe Lys Thr 
                325                 330                 335     


Lys His Asp 
            


<210>  4196
<211>  339
<212>  PRT
<213>  Homo Sapiens

<400>  4196

Met Asn Trp Glu Leu Leu Leu Trp Leu Leu Val Leu Cys Ala Leu Leu 
1               5                   10                  15      


Leu Leu Leu Val Gln Leu Leu Arg Phe Leu Arg Ala Asp Gly Asp Leu 
            20                  25                  30          


Thr Leu Leu Trp Ala Glu Trp Gln Gly Arg Arg Pro Glu Trp Glu Leu 
        35                  40                  45              


Thr Asp Met Val Val Trp Val Thr Gly Ala Ser Ser Gly Ile Gly Glu 
    50                  55                  60                  


Glu Leu Ala Tyr Gln Leu Ser Lys Leu Gly Val Ser Leu Val Leu Ser 
65                  70                  75                  80  


Ala Arg Arg Val His Glu Leu Glu Arg Val Lys Arg Arg Cys Leu Glu 
                85                  90                  95      


Asn Gly Asn Leu Lys Glu Lys Asp Ile Leu Val Leu Pro Leu Asp Leu 
            100                 105                 110         


Thr Asp Thr Gly Ser His Glu Ala Ala Thr Lys Ala Val Leu Gln Glu 
        115                 120                 125             


Phe Gly Arg Ile Asp Ile Leu Val Asn Asn Gly Gly Met Ser Gln Arg 
    130                 135                 140                 


Ser Leu Cys Met Asp Thr Ser Leu Asp Val Tyr Arg Lys Leu Ile Glu 
145                 150                 155                 160 


Leu Asn Tyr Leu Gly Thr Val Ser Leu Thr Lys Cys Val Leu Pro His 
                165                 170                 175     


Met Ile Glu Arg Lys Gln Gly Lys Ile Val Thr Val Asn Ser Ile Leu 
            180                 185                 190         


Gly Ile Ile Ser Val Pro Leu Ser Ile Gly Tyr Cys Ala Ser Lys His 
        195                 200                 205             


Ala Leu Arg Gly Phe Phe Asn Gly Leu Arg Thr Glu Leu Ala Thr Tyr 
    210                 215                 220                 


Pro Gly Ile Ile Val Ser Asn Ile Cys Pro Gly Pro Val Gln Ser Asn 
225                 230                 235                 240 


Ile Val Glu Asn Ser Leu Ala Gly Glu Val Thr Lys Thr Ile Gly Asn 
                245                 250                 255     


Asn Gly Asp Gln Ser His Lys Met Thr Thr Ser Arg Cys Val Arg Leu 
            260                 265                 270         


Met Leu Ile Ser Met Ala Asn Asp Leu Lys Glu Val Trp Ile Ser Glu 
        275                 280                 285             


Gln Pro Phe Leu Leu Val Thr Tyr Leu Trp Gln Tyr Met Pro Thr Trp 
    290                 295                 300                 


Ala Trp Trp Ile Thr Asn Lys Met Gly Lys Lys Arg Ile Glu Asn Phe 
305                 310                 315                 320 


Lys Ser Gly Val Asp Ala Asp Ser Ser Tyr Phe Lys Ile Phe Lys Thr 
                325                 330                 335     


Lys His Asp 
            


<210>  4197
<211>  376
<212>  PRT
<213>  Homo Sapiens

<400>  4197

Met Asn Trp Glu Leu Leu Leu Trp Leu Leu Val Leu Cys Ala Leu Leu 
1               5                   10                  15      


Leu Leu Leu Val Gln Leu Leu Arg Phe Leu Arg Ala Asp Gly Asp Leu 
            20                  25                  30          


Thr Leu Leu Trp Ala Glu Trp Gln Gly Arg Arg Pro Glu Trp Glu Leu 
        35                  40                  45              


Thr Asp Met Val Val Trp Val Thr Gly Ala Ser Ser Gly Ile Gly Glu 
    50                  55                  60                  


Glu Leu Ala Tyr Gln Leu Ser Lys Leu Gly Val Ser Leu Val Leu Ser 
65                  70                  75                  80  


Ala Arg Arg Val His Glu Leu Glu Arg Val Lys Arg Arg Cys Leu Glu 
                85                  90                  95      


Asn Gly Asn Leu Lys Glu Lys Asp Ile Leu Val Leu Pro Leu Asp Leu 
            100                 105                 110         


Thr Asp Thr Gly Ser His Glu Ala Ala Thr Lys Ala Val Leu Gln Glu 
        115                 120                 125             


Phe Gly Arg Ile Asp Ile Leu Val Asn Asn Gly Gly Met Ser Gln Arg 
    130                 135                 140                 


Ser Leu Cys Met Asp Thr Ser Leu Asp Val Tyr Arg Lys Leu Ile Glu 
145                 150                 155                 160 


Leu Asn Tyr Leu Gly Thr Val Ser Leu Thr Lys Cys Val Leu Pro His 
                165                 170                 175     


Met Ile Glu Arg Lys Gln Gly Lys Ile Val Thr Val Asn Ser Ile Leu 
            180                 185                 190         


Gly Ile Ile Ser Val Pro Leu Ser Ile Gly Tyr Cys Ala Ser Lys His 
        195                 200                 205             


Ala Leu Arg Gly Phe Phe Asn Gly Leu Arg Thr Glu Leu Ala Thr Tyr 
    210                 215                 220                 


Pro Gly Ile Ile Val Ser Asn Ile Cys Pro Gly Pro Val Gln Ser Asn 
225                 230                 235                 240 


Ile Val Glu Asn Ser Leu Ala Gly Glu Val Thr Lys Thr Ile Gly Asn 
                245                 250                 255     


Asn Gly Asp Gln Ser His Lys Met Thr Thr Ser Arg Cys Val Arg Leu 
            260                 265                 270         


Met Leu Ile Ser Met Ala Asn Asp Leu Lys Glu Val Trp Ile Ser Glu 
        275                 280                 285             


Gln Pro Phe Leu Leu Val Thr Tyr Leu Trp Gln Tyr Met Pro Thr Trp 
    290                 295                 300                 


Ala Trp Trp Ile Thr Thr Arg Trp Gly Arg Lys Gly Leu Arg Thr Leu 
305                 310                 315                 320 


Arg Val Val Trp Met Gln Thr Leu Leu Ile Leu Lys Ser Leu Arg Gln 
                325                 330                 335     


Asn Met Thr Glu Lys Ser Thr Cys Thr Phe Gln Ala Thr Gly Gly Arg 
            340                 345                 350         


Asn Gly Lys His Glu Asn Ser Asn Leu Leu Met Leu Leu Asn Asn Gln 
        355                 360                 365             


Arg Leu Ile Cys Asp Phe Thr Phe 
    370                 375     


<210>  4198
<211>  289
<212>  PRT
<213>  Homo Sapiens

<400>  4198

Met Val Val Trp Val Thr Gly Ala Ser Ser Gly Ile Gly Glu Glu Leu 
1               5                   10                  15      


Ala Tyr Gln Leu Ser Lys Leu Gly Val Ser Leu Val Leu Ser Ala Arg 
            20                  25                  30          


Arg Val His Glu Leu Glu Arg Val Lys Arg Arg Cys Leu Glu Asn Gly 
        35                  40                  45              


Asn Leu Lys Glu Lys Asp Ile Leu Val Leu Pro Leu Asp Leu Thr Asp 
    50                  55                  60                  


Thr Gly Ser His Glu Ala Ala Thr Lys Ala Val Leu Gln Glu Phe Gly 
65                  70                  75                  80  


Arg Ile Asp Ile Leu Val Asn Asn Gly Gly Met Ser Gln Arg Ser Leu 
                85                  90                  95      


Cys Met Asp Thr Ser Leu Asp Val Tyr Arg Lys Leu Ile Glu Leu Asn 
            100                 105                 110         


Tyr Leu Gly Thr Val Ser Leu Thr Lys Cys Val Leu Pro His Met Ile 
        115                 120                 125             


Glu Arg Lys Gln Gly Lys Ile Val Thr Val Asn Ser Ile Leu Gly Ile 
    130                 135                 140                 


Ile Ser Val Pro Leu Ser Ile Gly Tyr Cys Ala Ser Lys His Ala Leu 
145                 150                 155                 160 


Arg Gly Phe Phe Asn Gly Leu Arg Thr Glu Leu Ala Thr Tyr Pro Gly 
                165                 170                 175     


Ile Ile Val Ser Asn Ile Cys Pro Gly Pro Val Gln Ser Asn Ile Val 
            180                 185                 190         


Glu Asn Ser Leu Ala Gly Glu Val Thr Lys Thr Ile Gly Asn Asn Gly 
        195                 200                 205             


Asp Gln Ser His Lys Met Thr Thr Ser Arg Cys Val Arg Leu Met Leu 
    210                 215                 220                 


Ile Ser Met Ala Asn Asp Leu Lys Glu Val Trp Ile Ser Glu Gln Pro 
225                 230                 235                 240 


Phe Leu Leu Val Thr Tyr Leu Trp Gln Tyr Met Pro Thr Trp Ala Trp 
                245                 250                 255     


Trp Ile Thr Asn Lys Met Gly Lys Lys Arg Ile Glu Asn Phe Lys Ser 
            260                 265                 270         


Gly Val Asp Ala Asp Ser Ser Tyr Phe Lys Ile Phe Lys Thr Lys His 
        275                 280                 285             


Asp 
    


<210>  4199
<211>  212
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4199

Xaa Ile Leu Val Asn Asn Gly Gly Met Ser Gln Arg Ser Leu Cys Met 
1               5                   10                  15      


Asp Thr Ser Leu Asp Val Tyr Arg Lys Leu Ile Glu Leu Asn Tyr Leu 
            20                  25                  30          


Gly Thr Val Ser Leu Thr Lys Cys Val Leu Pro His Met Ile Glu Arg 
        35                  40                  45              


Lys Gln Gly Lys Ile Val Thr Val Asn Ser Ile Leu Gly Ile Ile Ser 
    50                  55                  60                  


Val Pro Leu Ser Ile Gly Tyr Cys Ala Ser Lys His Ala Leu Arg Gly 
65                  70                  75                  80  


Phe Phe Asn Gly Leu Arg Thr Glu Leu Ala Thr Tyr Pro Gly Ile Ile 
                85                  90                  95      


Val Ser Asn Ile Cys Pro Gly Pro Val Gln Ser Asn Ile Val Glu Asn 
            100                 105                 110         


Ser Leu Ala Gly Glu Val Thr Lys Thr Ile Gly Asn Asn Gly Asp Gln 
        115                 120                 125             


Ser His Lys Met Thr Thr Ser Arg Cys Val Arg Leu Met Leu Ile Ser 
    130                 135                 140                 


Met Ala Asn Asp Leu Lys Glu Val Trp Ile Ser Glu Gln Pro Phe Leu 
145                 150                 155                 160 


Met Gln Thr Leu Leu Ile Leu Lys Ser Leu Arg Gln Asn Met Thr Glu 
                165                 170                 175     


Lys Ser Thr Cys Thr Phe Gln Ala Thr Gly Gly Arg Asn Gly Lys His 
            180                 185                 190         


Glu Asn Ser Asn Leu Leu Met Leu Leu Asn Asn Gln Arg Leu Ile Cys 
        195                 200                 205             


Asp Phe Thr Phe 
    210         


<210>  4200
<211>  399
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4200

Xaa Leu Trp Leu Leu Val Leu Cys Ala Leu Leu Leu Leu Leu Val Gln 
1               5                   10                  15      


Leu Leu Arg Phe Leu Arg Ala Asp Gly Asp Leu Thr Leu Leu Trp Ala 
            20                  25                  30          


Glu Trp Gln Gly Arg Arg Pro Glu Trp Glu Leu Thr Asp Met Val Val 
        35                  40                  45              


Trp Val Thr Gly Ala Ser Ser Gly Ile Gly Glu Glu Leu Ala Tyr Gln 
    50                  55                  60                  


Leu Ser Lys Leu Gly Val Ser Leu Val Leu Ser Ala Arg Arg Val His 
65                  70                  75                  80  


Glu Leu Glu Arg Val Lys Arg Arg Cys Leu Glu Asn Gly Asn Leu Lys 
                85                  90                  95      


Glu Lys Asp Ile Leu Val Leu Pro Leu Asp Leu Thr Asp Thr Gly Ser 
            100                 105                 110         


His Glu Ala Ala Thr Lys Ala Val Leu Gln Glu Phe Gly Arg Ile Asp 
        115                 120                 125             


Ile Leu Val Asn Asn Gly Gly Met Ser Gln Arg Ser Leu Cys Met Asp 
    130                 135                 140                 


Thr Ser Leu Asp Val Tyr Arg Lys Leu Ile Glu Leu Asn Tyr Leu Gly 
145                 150                 155                 160 


Thr Val Ser Leu Thr Lys Cys Val Leu Pro His Met Ile Glu Arg Lys 
                165                 170                 175     


Gln Gly Lys Ile Val Thr Val Asn Ser Ile Leu Gly Ile Ile Ser Val 
            180                 185                 190         


Pro Leu Ser Ile Gly Tyr Cys Ala Ser Lys His Ala Leu Arg Gly Phe 
        195                 200                 205             


Phe Asn Gly Leu Arg Thr Glu Leu Ala Thr Tyr Pro Gly Ile Ile Val 
    210                 215                 220                 


Ser Asn Ile Cys Pro Gly Pro Val Gln Ser Asn Ile Val Glu Asn Ser 
225                 230                 235                 240 


Leu Ala Gly Glu Val Thr Lys Thr Ile Gly Asn Asn Gly Asp Gln Ser 
                245                 250                 255     


His Lys Met Thr Thr Ser Arg Cys Val Arg Leu Met Leu Ile Ser Met 
            260                 265                 270         


Ala Asn Asp Leu Lys Glu Val Trp Ile Ser Glu Gln Pro Phe Leu Leu 
        275                 280                 285             


Val Thr Tyr Leu Trp Gln Tyr Met Pro Thr Trp Ala Trp Trp Ile Thr 
    290                 295                 300                 


Asn Lys Met Gly Lys Lys Arg Ile Glu Asn Phe Lys Ser Gly Val Val 
305                 310                 315                 320 


Arg Pro Ile Ser Lys Phe Leu Asn Ser Met Tyr Gln Ser Cys Arg Lys 
                325                 330                 335     


Val Gln Asn Phe Pro Val Phe Lys Lys Leu Ser Gly Trp Val Gln Trp 
            340                 345                 350         


Leu Met Ser Val Ile Pro Ala Leu Trp Glu Ala Lys Ala Asp His Leu 
        355                 360                 365             


Arg Pro Gly Val Gln Asp Gln Pro Gly Gln His Ser Glu Thr Pro Ser 
    370                 375                 380                 


Leu Leu Lys Ile Gln Lys Val Ala Gly His Gly Gly Ala Cys Leu 
385                 390                 395                 


<210>  4201
<211>  160
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4201

Xaa Asn Trp Glu Leu Leu Leu Trp Leu Leu Val Leu Cys Ala Leu Leu 
1               5                   10                  15      


Leu Leu Leu Val Gln Leu Leu Arg Phe Leu Arg Ala Asp Gly Asp Leu 
            20                  25                  30          


Thr Leu Leu Trp Ala Glu Trp Gln Gly Arg Arg Pro Glu Trp Glu Leu 
        35                  40                  45              


Thr Asp Met Val Val Trp Val Thr Gly Ala Ser Ser Gly Ile Gly Glu 
    50                  55                  60                  


Glu Leu Ala Tyr Gln Leu Ser Lys Leu Gly Val Ser Leu Val Leu Ser 
65                  70                  75                  80  


Ala Arg Arg Val His Glu Leu Glu Arg Val Lys Arg Arg Cys Leu Glu 
                85                  90                  95      


Asn Gly Asn Leu Lys Glu Lys Asp Ile Leu Val Leu Pro Leu Asp Leu 
            100                 105                 110         


Thr Asp Thr Gly Ser His Glu Ala Ala Thr Lys Ala Val Leu Gln Glu 
        115                 120                 125             


Phe Gly Arg Gly Phe Phe Asn Gly Leu Arg Thr Glu Leu Ala Thr Tyr 
    130                 135                 140                 


Pro Gly Ile Ile Val Ser Asn Ile Cys Pro Gly Pro Val Gln Ser Asn 
145                 150                 155                 160 


<210>  4202
<211>  312
<212>  PRT
<213>  Homo Sapiens

<400>  4202

Met Gly Val Met Ala Met Leu Met Leu Pro Leu Leu Leu Leu Gly Ile 
1               5                   10                  15      


Ser Gly Leu Leu Phe Ile Tyr Gln Glu Val Ser Arg Leu Trp Ser Lys 
            20                  25                  30          


Ser Ala Val Gln Asn Lys Val Val Val Ile Thr Asp Ala Ile Ser Gly 
        35                  40                  45              


Leu Gly Lys Glu Cys Ala Arg Val Phe His Thr Gly Gly Ala Arg Leu 
    50                  55                  60                  


Val Leu Cys Gly Lys Asn Trp Glu Arg Leu Glu Asn Leu Tyr Asp Ala 
65                  70                  75                  80  


Leu Ile Ser Val Ala Asp Pro Ser Lys Gln Thr Phe Thr Pro Lys Leu 
                85                  90                  95      


Val Leu Leu Asp Leu Ser Asp Ile Ser Cys Val Pro Asp Val Ala Lys 
            100                 105                 110         


Glu Val Leu Asp Cys Tyr Gly Cys Val Asp Ile Leu Ile Asn Asn Ala 
        115                 120                 125             


Ser Val Lys Val Lys Gly Pro Ala His Lys Ile Ser Leu Glu Leu Asp 
    130                 135                 140                 


Lys Lys Ile Met Asp Ala Asn Tyr Phe Gly Pro Ile Thr Leu Thr Lys 
145                 150                 155                 160 


Ala Leu Leu Pro Asn Met Ile Ser Arg Arg Thr Gly Gln Ile Val Leu 
                165                 170                 175     


Val Asn Asn Ile Gln Gly Lys Phe Gly Ile Pro Phe Arg Thr Thr Tyr 
            180                 185                 190         


Ala Ala Ser Lys His Ala Ala Leu Gly Phe Phe Asp Cys Leu Arg Ala 
        195                 200                 205             


Glu Val Glu Glu Tyr Asp Val Val Ile Ser Thr Val Ser Pro Thr Phe 
    210                 215                 220                 


Ile Arg Ser Tyr His Val Tyr Pro Glu Gln Gly Asn Trp Glu Ala Ser 
225                 230                 235                 240 


Ile Trp Lys Phe Phe Phe Arg Lys Leu Thr Tyr Gly Val His Pro Val 
                245                 250                 255     


Glu Val Ala Glu Glu Val Met Arg Thr Val Arg Arg Lys Lys Gln Glu 
            260                 265                 270         


Val Phe Met Ala Asn Pro Ile Pro Lys Ala Ala Val Tyr Val Arg Thr 
        275                 280                 285             


Phe Phe Pro Glu Phe Phe Phe Ala Val Val Ala Cys Gly Val Lys Glu 
    290                 295                 300                 


Lys Leu Asn Val Pro Glu Glu Gly 
305                 310         


<210>  4203
<211>  311
<212>  PRT
<213>  Homo Sapiens

<400>  4203

Met Gly Val Met Ala Met Leu Met Leu Pro Leu Leu Leu Leu Gly Ile 
1               5                   10                  15      


Ser Gly Leu Leu Phe Ile Tyr Gln Glu Val Ser Arg Leu Trp Ser Lys 
            20                  25                  30          


Ser Ala Val Gln Asn Lys Val Val Val Ile Thr Asp Ala Ile Ser Gly 
        35                  40                  45              


Leu Gly Lys Glu Cys Ala Arg Val Phe His Thr Gly Gly Ala Arg Leu 
    50                  55                  60                  


Val Leu Cys Gly Lys Asn Trp Glu Arg Leu Glu Asn Leu Tyr Asp Ala 
65                  70                  75                  80  


Leu Ile Ser Val Ala Asp Pro Ser Lys Thr Phe Thr Pro Lys Leu Val 
                85                  90                  95      


Leu Leu Asp Leu Ser Asp Ile Ser Cys Val Pro Asp Val Ala Lys Glu 
            100                 105                 110         


Val Leu Asp Cys Tyr Gly Cys Val Asp Ile Leu Ile Asn Asn Ala Ser 
        115                 120                 125             


Val Lys Val Lys Gly Pro Ala His Lys Ile Ser Leu Glu Leu Asp Lys 
    130                 135                 140                 


Lys Ile Met Asp Ala Asn Tyr Phe Gly Pro Ile Thr Leu Thr Lys Ala 
145                 150                 155                 160 


Leu Leu Pro Asn Met Ile Ser Arg Arg Thr Gly Gln Ile Val Leu Val 
                165                 170                 175     


Asn Asn Ile Gln Gly Lys Phe Gly Ile Pro Phe Arg Thr Thr Tyr Ala 
            180                 185                 190         


Ala Ser Lys His Ala Ala Leu Gly Phe Phe Asp Cys Leu Arg Ala Glu 
        195                 200                 205             


Val Glu Glu Tyr Asp Val Val Ile Ser Thr Val Ser Pro Thr Phe Ile 
    210                 215                 220                 


Arg Ser Tyr His Val Tyr Pro Glu Gln Gly Asn Trp Glu Ala Ser Ile 
225                 230                 235                 240 


Trp Lys Phe Phe Phe Arg Lys Leu Thr Tyr Gly Val His Pro Val Glu 
                245                 250                 255     


Val Ala Glu Glu Val Met Arg Thr Val Arg Arg Lys Lys Gln Glu Val 
            260                 265                 270         


Phe Met Ala Asn Pro Ile Pro Lys Ala Ala Val Tyr Val Arg Thr Phe 
        275                 280                 285             


Phe Pro Glu Phe Phe Phe Ala Val Val Ala Cys Gly Val Lys Glu Lys 
    290                 295                 300                 


Leu Asn Val Pro Glu Glu Gly 
305                 310     


<210>  4204
<211>  132
<212>  PRT
<213>  Homo Sapiens

<400>  4204

Ser Val Lys Val Lys Gly Pro Ala His Lys Ile Ser Leu Glu Leu Asp 
1               5                   10                  15      


Lys Lys Ile Met Asp Ala Asn Tyr Phe Gly Pro Ile Thr Leu Thr Lys 
            20                  25                  30          


Ala Leu Leu Pro Asn Met Ile Ser Arg Arg Thr Gly Gln Ile Val Leu 
        35                  40                  45              


Val Asn Asn Ile Gln Gly Lys Phe Gly Ile Pro Phe Arg Thr Thr Phe 
    50                  55                  60                  


Phe Phe Arg Lys Leu Thr Tyr Gly Val His Pro Val Glu Val Ala Glu 
65                  70                  75                  80  


Glu Val Met Arg Thr Val Arg Arg Lys Lys Gln Glu Val Phe Met Ala 
                85                  90                  95      


Asn Pro Ile Pro Lys Ala Ala Val Tyr Val Arg Thr Phe Phe Pro Glu 
            100                 105                 110         


Phe Phe Phe Ala Val Val Ala Cys Gly Val Lys Glu Lys Leu Asn Val 
        115                 120                 125             


Pro Glu Glu Gly 
    130         


<210>  4205
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  4205

Met Leu Phe Trp Val Leu Gly Leu Leu Ile Leu Cys Gly Phe Leu Trp 
1               5                   10                  15      


Thr Arg Lys Gly Lys Leu Lys Ile Glu Asp Ile Thr Asp Lys Tyr Ile 
            20                  25                  30          


Phe Ile Thr Gly Cys Asp Ser Gly Phe Gly Asn Leu Ala Ala Arg Thr 
        35                  40                  45              


Phe Asp Lys Lys Gly Phe His Val Ile Ala Ala Cys Leu Thr Glu Ser 
    50                  55                  60                  


Gly Ser 
65      


<210>  4206
<211>  319
<212>  PRT
<213>  Homo Sapiens

<400>  4206

Met Leu Phe Trp Val Leu Gly Leu Leu Ile Leu Cys Gly Phe Leu Trp 
1               5                   10                  15      


Thr Arg Lys Gly Lys Leu Lys Ile Glu Asp Ile Thr Asp Lys Tyr Ile 
            20                  25                  30          


Phe Ile Thr Gly Cys Asp Ser Gly Phe Gly Asn Leu Ala Ala Arg Thr 
        35                  40                  45              


Phe Asp Lys Lys Gly Phe His Val Ile Ala Ala Cys Leu Thr Glu Ser 
    50                  55                  60                  


Gly Ser Thr Ala Leu Lys Ala Glu Thr Ser Glu Arg Leu Arg Thr Val 
65                  70                  75                  80  


Leu Leu Asp Val Thr Asp Pro Glu Asn Val Lys Arg Thr Ala Gln Trp 
                85                  90                  95      


Val Lys Asn Gln Val Gly Glu Lys Gly Leu Trp Gly Leu Ile Asn Asn 
            100                 105                 110         


Ala Gly Val Pro Gly Val Leu Ala Pro Thr Asp Trp Leu Thr Leu Glu 
        115                 120                 125             


Asp Tyr Arg Glu Pro Ile Glu Val Asn Leu Phe Gly Leu Ile Ser Val 
    130                 135                 140                 


Thr Leu Asn Met Leu Pro Leu Val Lys Lys Ala Gln Gly Arg Val Ile 
145                 150                 155                 160 


Asn Val Ser Ser Val Gly Gly Arg Leu Ala Ile Val Gly Gly Gly Tyr 
                165                 170                 175     


Thr Pro Ser Lys Tyr Ala Val Glu Gly Phe Asn Asp Ser Leu Arg Arg 
            180                 185                 190         


Asp Met Lys Ala Phe Gly Val His Val Ser Cys Ile Glu Pro Gly Leu 
        195                 200                 205             


Phe Lys Thr Asn Leu Ala Asp Pro Val Lys Val Ile Glu Lys Lys Leu 
    210                 215                 220                 


Ala Ile Trp Glu Gln Leu Ser Pro Asp Ile Lys Gln Gln Tyr Gly Glu 
225                 230                 235                 240 


Gly Tyr Ile Glu Lys Ser Leu Asp Lys Leu Lys Gly Asn Lys Ser Tyr 
                245                 250                 255     


Val Asn Met Asp Leu Ser Pro Val Val Glu Cys Met Asp His Ala Leu 
            260                 265                 270         


Thr Ser Leu Phe Pro Lys Thr His Tyr Ala Ala Gly Lys Asp Ala Lys 
        275                 280                 285             


Ile Phe Trp Ile Pro Leu Ser His Met Pro Ala Ala Leu Gln Asp Phe 
    290                 295                 300                 


Leu Leu Leu Lys Gln Lys Ala Glu Leu Ala Asn Pro Lys Ala Val 
305                 310                 315                 


<210>  4207
<211>  319
<212>  PRT
<213>  Homo Sapiens

<400>  4207

Met Leu Phe Trp Val Leu Gly Leu Leu Ile Leu Cys Gly Phe Leu Trp 
1               5                   10                  15      


Thr Arg Lys Gly Lys Leu Lys Ile Glu Asp Ile Thr Asp Lys Tyr Ile 
            20                  25                  30          


Phe Ile Thr Gly Cys Asp Ser Gly Phe Gly Asn Leu Ala Ala Arg Thr 
        35                  40                  45              


Phe Asp Lys Lys Gly Phe His Val Ile Ala Ala Cys Leu Thr Glu Ser 
    50                  55                  60                  


Gly Ser Thr Ala Leu Lys Ala Glu Thr Ser Glu Arg Leu Arg Thr Val 
65                  70                  75                  80  


Leu Leu Asp Val Thr Asp Pro Glu Asn Val Lys Arg Thr Ala Gln Trp 
                85                  90                  95      


Val Lys Asn Gln Val Gly Glu Lys Gly Leu Trp Gly Leu Ile Asn Asn 
            100                 105                 110         


Ala Gly Val Pro Gly Val Leu Ala Pro Thr Asp Trp Leu Thr Leu Glu 
        115                 120                 125             


Asp Tyr Arg Glu Pro Ile Glu Val Asn Leu Phe Gly Leu Ile Ser Val 
    130                 135                 140                 


Thr Leu Asn Met Leu Pro Leu Val Lys Lys Ala Gln Gly Arg Val Ile 
145                 150                 155                 160 


Asn Val Ser Ser Val Gly Gly Arg Leu Ala Ile Val Gly Gly Gly Tyr 
                165                 170                 175     


Thr Pro Ser Lys Tyr Ala Val Glu Gly Phe Asn Asp Ser Leu Arg Arg 
            180                 185                 190         


Asp Met Lys Ala Phe Gly Val His Val Ser Cys Ile Glu Pro Gly Leu 
        195                 200                 205             


Phe Lys Thr Asn Leu Ala Asp Pro Val Lys Val Ile Glu Lys Lys Leu 
    210                 215                 220                 


Ala Ile Trp Glu Gln Leu Ser Pro Asp Ile Lys Gln Gln Tyr Gly Glu 
225                 230                 235                 240 


Gly Tyr Ile Glu Lys Ser Leu Asp Lys Leu Lys Gly Asn Lys Ser Tyr 
                245                 250                 255     


Val Asn Met Asp Leu Ser Pro Val Val Glu Cys Met Asp His Ala Leu 
            260                 265                 270         


Thr Ser Leu Phe Pro Lys Thr His Tyr Ala Ala Gly Lys Asp Ala Lys 
        275                 280                 285             


Ile Phe Trp Ile Pro Leu Ser His Met Pro Ala Ala Leu Gln Asp Phe 
    290                 295                 300                 


Leu Leu Leu Lys Gln Lys Ala Glu Leu Ala Asn Pro Lys Ala Val 
305                 310                 315                 


<210>  4208
<211>  319
<212>  PRT
<213>  Homo Sapiens

<400>  4208

Met Leu Phe Trp Val Leu Gly Leu Leu Ile Leu Cys Gly Phe Leu Trp 
1               5                   10                  15      


Thr Arg Lys Gly Lys Leu Lys Ile Glu Asp Ile Thr Asp Lys Tyr Ile 
            20                  25                  30          


Phe Ile Thr Gly Cys Asp Ser Gly Phe Gly Asn Leu Ala Ala Arg Thr 
        35                  40                  45              


Phe Asp Lys Lys Gly Phe His Val Ile Ala Ala Cys Leu Thr Glu Ser 
    50                  55                  60                  


Gly Ser Thr Ala Leu Lys Ala Glu Thr Ser Glu Arg Leu Arg Thr Val 
65                  70                  75                  80  


Leu Leu Asp Val Thr Asp Pro Glu Asn Val Lys Arg Thr Ala Gln Trp 
                85                  90                  95      


Val Lys Asn Gln Val Gly Glu Lys Gly Leu Trp Gly Leu Ile Asn Asn 
            100                 105                 110         


Ala Gly Val Pro Gly Val Leu Ala Pro Thr Asp Trp Leu Thr Leu Glu 
        115                 120                 125             


Asp Tyr Arg Glu Pro Ile Glu Val Asn Leu Phe Gly Leu Ile Ser Val 
    130                 135                 140                 


Thr Leu Asn Met Leu Pro Leu Val Lys Lys Ala Gln Gly Arg Val Ile 
145                 150                 155                 160 


Asn Val Ser Ser Val Gly Gly Arg Leu Ala Ile Val Gly Gly Gly Tyr 
                165                 170                 175     


Thr Pro Ser Lys Tyr Ala Val Glu Gly Phe Asn Asp Ser Leu Arg Arg 
            180                 185                 190         


Asp Met Lys Ala Phe Gly Val His Val Ser Cys Ile Glu Pro Gly Leu 
        195                 200                 205             


Phe Lys Thr Asn Leu Ala Asp Pro Val Lys Val Ile Glu Lys Lys Leu 
    210                 215                 220                 


Ala Ile Trp Glu Gln Leu Ser Pro Asp Ile Lys Gln Gln Tyr Gly Glu 
225                 230                 235                 240 


Gly Tyr Ile Glu Lys Ser Leu Asp Lys Leu Lys Gly Asn Lys Ser Tyr 
                245                 250                 255     


Val Asn Met Asp Leu Ser Pro Val Val Glu Cys Met Asp His Ala Leu 
            260                 265                 270         


Thr Ser Leu Phe Pro Lys Thr His Tyr Ala Ala Gly Lys Asp Ala Lys 
        275                 280                 285             


Ile Phe Trp Ile Pro Leu Ser His Met Pro Ala Ala Leu Gln Asp Phe 
    290                 295                 300                 


Leu Leu Leu Lys Gln Lys Ala Glu Leu Ala Asn Pro Lys Ala Val 
305                 310                 315                 


<210>  4209
<211>  319
<212>  PRT
<213>  Homo Sapiens

<400>  4209

Met Leu Phe Trp Val Leu Gly Leu Leu Ile Leu Cys Gly Phe Leu Trp 
1               5                   10                  15      


Thr Arg Lys Gly Lys Leu Lys Ile Glu Asp Ile Thr Asp Lys Tyr Ile 
            20                  25                  30          


Phe Ile Thr Gly Cys Asp Ser Gly Phe Gly Asn Leu Ala Ala Arg Thr 
        35                  40                  45              


Phe Asp Lys Lys Gly Phe His Val Ile Ala Ala Cys Leu Thr Glu Ser 
    50                  55                  60                  


Gly Ser Thr Ala Leu Lys Ala Glu Thr Ser Glu Arg Leu Arg Thr Val 
65                  70                  75                  80  


Leu Leu Asp Val Thr Asp Pro Glu Asn Val Lys Arg Thr Ala Gln Trp 
                85                  90                  95      


Val Lys Asn Gln Val Gly Glu Lys Gly Leu Trp Gly Leu Ile Asn Asn 
            100                 105                 110         


Ala Gly Val Pro Gly Val Leu Ala Pro Thr Asp Trp Leu Thr Leu Glu 
        115                 120                 125             


Asp Tyr Arg Glu Pro Ile Glu Val Asn Leu Phe Gly Leu Ile Ser Val 
    130                 135                 140                 


Thr Leu Asn Met Leu Pro Leu Val Lys Lys Ala Gln Gly Arg Val Ile 
145                 150                 155                 160 


Asn Val Ser Ser Val Gly Gly Arg Leu Ala Ile Val Gly Gly Gly Tyr 
                165                 170                 175     


Thr Pro Ser Lys Tyr Ala Val Glu Gly Phe Asn Asp Ser Leu Arg Arg 
            180                 185                 190         


Asp Met Lys Ala Phe Gly Val His Val Ser Cys Ile Glu Pro Gly Leu 
        195                 200                 205             


Phe Lys Thr Asn Leu Ala Asp Pro Val Lys Val Ile Glu Lys Lys Leu 
    210                 215                 220                 


Ala Ile Trp Glu Gln Leu Ser Pro Asp Ile Lys Gln Gln Tyr Gly Glu 
225                 230                 235                 240 


Gly Tyr Ile Glu Lys Ser Leu Asp Lys Leu Lys Gly Asn Lys Ser Tyr 
                245                 250                 255     


Val Asn Met Asp Leu Ser Pro Val Val Glu Cys Met Asp His Ala Leu 
            260                 265                 270         


Thr Ser Leu Phe Pro Lys Thr His Tyr Ala Ala Gly Lys Asp Ala Lys 
        275                 280                 285             


Ile Phe Trp Ile Pro Leu Ser His Met Pro Ala Ala Leu Gln Asp Phe 
    290                 295                 300                 


Leu Leu Leu Lys Gln Lys Ala Glu Leu Ala Asn Pro Lys Ala Val 
305                 310                 315                 


<210>  4210
<211>  319
<212>  PRT
<213>  Homo Sapiens

<400>  4210

Met Leu Phe Trp Val Leu Gly Leu Leu Ile Leu Cys Gly Phe Leu Trp 
1               5                   10                  15      


Thr Arg Lys Gly Lys Leu Lys Ile Glu Asp Ile Thr Asp Lys Tyr Ile 
            20                  25                  30          


Phe Ile Thr Gly Cys Asp Ser Gly Phe Gly Asn Leu Ala Ala Arg Thr 
        35                  40                  45              


Phe Asp Lys Lys Gly Phe His Val Ile Ala Ala Cys Leu Thr Glu Ser 
    50                  55                  60                  


Gly Ser Thr Ala Leu Lys Ala Glu Thr Ser Glu Arg Leu Arg Thr Val 
65                  70                  75                  80  


Leu Leu Asp Val Thr Asp Pro Glu Asn Val Lys Arg Thr Ala Gln Trp 
                85                  90                  95      


Val Lys Asn Gln Val Gly Glu Lys Gly Leu Trp Gly Leu Ile Asn Asn 
            100                 105                 110         


Ala Gly Val Pro Gly Val Leu Ala Pro Thr Asp Trp Leu Thr Leu Glu 
        115                 120                 125             


Asp Tyr Arg Glu Pro Ile Glu Val Asn Leu Phe Gly Leu Ile Ser Val 
    130                 135                 140                 


Thr Leu Asn Met Leu Pro Leu Val Lys Lys Ala Gln Gly Arg Val Ile 
145                 150                 155                 160 


Asn Val Ser Ser Val Gly Gly Arg Leu Ala Ile Val Gly Gly Gly Tyr 
                165                 170                 175     


Thr Pro Ser Lys Tyr Ala Val Glu Gly Phe Asn Asp Ser Leu Arg Arg 
            180                 185                 190         


Asp Met Lys Ala Phe Gly Val His Val Ser Cys Ile Glu Pro Gly Leu 
        195                 200                 205             


Phe Lys Thr Asn Leu Ala Asp Pro Val Lys Val Ile Glu Lys Lys Leu 
    210                 215                 220                 


Ala Ile Trp Glu Gln Leu Ser Pro Asp Ile Lys Gln Gln Tyr Gly Glu 
225                 230                 235                 240 


Gly Tyr Ile Glu Lys Ser Leu Asp Lys Leu Lys Gly Asn Lys Ser Tyr 
                245                 250                 255     


Val Asn Met Asp Leu Ser Pro Val Val Glu Cys Met Asp His Ala Leu 
            260                 265                 270         


Thr Ser Leu Phe Pro Lys Thr His Tyr Ala Ala Gly Lys Asp Ala Lys 
        275                 280                 285             


Ile Phe Trp Ile Pro Leu Ser His Met Pro Ala Ala Leu Gln Asp Phe 
    290                 295                 300                 


Leu Leu Leu Lys Gln Lys Ala Glu Leu Ala Asn Pro Lys Ala Val 
305                 310                 315                 


<210>  4211
<211>  172
<212>  PRT
<213>  Homo Sapiens

<400>  4211

Met Leu Pro Leu Val Lys Lys Ala Gln Gly Arg Val Ile Asn Val Ser 
1               5                   10                  15      


Ser Val Gly Gly Arg Leu Ala Ile Val Gly Gly Gly Tyr Thr Pro Ser 
            20                  25                  30          


Lys Tyr Ala Val Glu Gly Phe Asn Asp Ser Leu Arg Arg Asp Met Lys 
        35                  40                  45              


Ala Phe Gly Val His Val Ser Cys Ile Glu Pro Gly Leu Phe Lys Thr 
    50                  55                  60                  


Asn Leu Ala Asp Pro Val Lys Val Ile Glu Lys Lys Leu Ala Ile Trp 
65                  70                  75                  80  


Glu Gln Leu Ser Pro Asp Ile Lys Gln Gln Tyr Gly Glu Gly Tyr Ile 
                85                  90                  95      


Glu Lys Ser Leu Asp Lys Leu Lys Gly Asn Lys Ser Tyr Val Asn Met 
            100                 105                 110         


Asp Leu Ser Pro Val Val Glu Cys Met Asp His Ala Leu Thr Ser Leu 
        115                 120                 125             


Phe Pro Lys Thr His Tyr Ala Ala Gly Lys Asp Ala Lys Ile Phe Trp 
    130                 135                 140                 


Ile Pro Leu Ser His Met Pro Ala Ala Leu Gln Asp Phe Leu Leu Leu 
145                 150                 155                 160 


Lys Gln Lys Ala Glu Leu Ala Asn Pro Lys Ala Val 
                165                 170         


<210>  4212
<211>  379
<212>  PRT
<213>  Homo Sapiens

<400>  4212

Met Pro Glu Gly Arg Ser His Cys Ala Cys Ser Ile Thr Ser Leu Thr 
1               5                   10                  15      


Leu Leu Val Ser Leu Thr Arg Val Thr Leu Asp Ile Leu Gln Lys Leu 
            20                  25                  30          


Asp Pro Pro Gln Pro Ala His Trp Arg His His Leu Leu Val Leu Tyr 
        35                  40                  45              


Lys Lys Gly Val Tyr Leu Ser His Thr Gly Gly Lys Met Leu Phe Trp 
    50                  55                  60                  


Val Leu Gly Leu Leu Ile Leu Cys Gly Phe Leu Trp Thr Arg Lys Gly 
65                  70                  75                  80  


Lys Leu Lys Ile Glu Asp Ile Thr Asp Lys Tyr Ile Phe Ile Thr Gly 
                85                  90                  95      


Cys Asp Ser Gly Phe Gly Asn Leu Ala Ala Arg Thr Phe Asp Lys Lys 
            100                 105                 110         


Gly Phe His Val Ile Ala Ala Cys Leu Thr Glu Ser Gly Ser Thr Ala 
        115                 120                 125             


Leu Lys Ala Glu Thr Ser Glu Arg Leu Arg Thr Val Leu Leu Asp Val 
    130                 135                 140                 


Thr Asp Pro Glu Asn Val Lys Arg Thr Ala Gln Trp Val Lys Asn Gln 
145                 150                 155                 160 


Val Gly Glu Lys Gly Leu Trp Gly Leu Ile Asn Asn Ala Gly Val Pro 
                165                 170                 175     


Gly Val Leu Ala Pro Thr Asp Trp Leu Thr Leu Glu Asp Tyr Arg Glu 
            180                 185                 190         


Pro Ile Glu Val Asn Leu Phe Gly Leu Ile Ser Val Thr Leu Asn Met 
        195                 200                 205             


Leu Pro Leu Val Lys Lys Ala Gln Gly Arg Val Ile Asn Val Ser Ser 
    210                 215                 220                 


Val Gly Gly Arg Leu Ala Ile Val Gly Gly Gly Tyr Thr Pro Ser Lys 
225                 230                 235                 240 


Tyr Ala Val Glu Gly Phe Asn Asp Ser Leu Arg Arg Asp Met Lys Ala 
                245                 250                 255     


Phe Gly Val His Val Ser Cys Ile Glu Pro Gly Leu Phe Lys Thr Asn 
            260                 265                 270         


Leu Ala Asp Pro Val Lys Val Ile Glu Lys Lys Leu Ala Ile Trp Glu 
        275                 280                 285             


Gln Leu Ser Pro Asp Ile Lys Gln Gln Tyr Gly Glu Gly Tyr Ile Glu 
    290                 295                 300                 


Lys Ser Leu Asp Lys Leu Lys Gly Asn Lys Ser Tyr Val Asn Met Asp 
305                 310                 315                 320 


Leu Ser Pro Val Val Glu Cys Met Asp His Ala Leu Thr Ser Leu Phe 
                325                 330                 335     


Pro Lys Thr His Tyr Ala Ala Gly Lys Asp Ala Lys Ile Phe Trp Ile 
            340                 345                 350         


Pro Leu Ser His Met Pro Ala Ala Leu Gln Asp Phe Leu Leu Leu Lys 
        355                 360                 365             


Gln Lys Ala Glu Leu Ala Asn Pro Lys Ala Val 
    370                 375                 


<210>  4213
<211>  122
<212>  PRT
<213>  Homo Sapiens

<400>  4213

Met His Val Ile Ile Ala Gly Asn Asn Asp Ser Lys Ala Lys Gln Val 
1               5                   10                  15      


Val Ser Lys Ile Lys Glu Glu Thr Leu Asn Asp Lys Val Glu Phe Leu 
            20                  25                  30          


Tyr Cys Asp Leu Ala Ser Met Thr Ser Ile Arg Gln Phe Val Gln Lys 
        35                  40                  45              


Phe Lys Met Lys Lys Ile Pro Leu His Val Leu Ile Asn Asn Ala Gly 
    50                  55                  60                  


Val Met Met Val Pro Gln Arg Lys Thr Arg Asp Gly Phe Glu Glu His 
65                  70                  75                  80  


Phe Gly Leu Asn Tyr Leu Gly His Phe Leu Leu Thr Asn Leu Leu Leu 
                85                  90                  95      


Asp Thr Leu Lys Glu Ser Gly Ser Pro Gly His Ser Ala Arg Val Val 
            100                 105                 110         


Thr Val Ser Ser Ala Thr His Tyr Val Ala 
        115                 120         


<210>  4214
<211>  63
<212>  PRT
<213>  Homo Sapiens

<400>  4214

Met Pro Val Phe Pro Pro Arg Pro Asp Arg Val Ala Ile Val Thr Gly 
1               5                   10                  15      


Gly Thr Asp Gly Ile Gly Tyr Ser Thr Ala Lys His Leu Ala Arg Leu 
            20                  25                  30          


Gly Met His Val Ile Ile Ala Gly Asn Asn Asp Ser Lys Ala Lys Gln 
        35                  40                  45              


Val Val Ser Lys Ile Lys Glu Glu Thr Leu Asn Asp Lys Glu Thr 
    50                  55                  60              


<210>  4215
<211>  330
<212>  PRT
<213>  Homo Sapiens

<400>  4215

Met Ser Pro Leu Ser Ala Ala Arg Ala Ala Leu Arg Val Tyr Ala Val 
1               5                   10                  15      


Gly Ala Ala Val Ile Leu Ala Gln Leu Leu Arg Arg Cys Arg Gly Gly 
            20                  25                  30          


Phe Leu Glu Pro Val Phe Pro Pro Arg Pro Asp Arg Val Ala Ile Val 
        35                  40                  45              


Thr Gly Gly Thr Asp Gly Ile Gly Tyr Ser Thr Ala Lys His Leu Ala 
    50                  55                  60                  


Arg Leu Gly Met His Val Ile Ile Ala Gly Asn Asn Asp Ser Lys Ala 
65                  70                  75                  80  


Lys Gln Val Val Ser Lys Ile Lys Glu Glu Thr Leu Asn Asp Lys Val 
                85                  90                  95      


Glu Phe Leu Tyr Cys Asp Leu Ala Ser Met Thr Ser Ile Arg Gln Phe 
            100                 105                 110         


Val Gln Lys Phe Lys Met Lys Lys Ile Pro Leu His Val Leu Ile Asn 
        115                 120                 125             


Asn Ala Gly Val Met Met Val Pro Gln Arg Lys Thr Arg Asp Gly Phe 
    130                 135                 140                 


Glu Glu His Phe Gly Leu Asn Tyr Leu Gly His Phe Leu Leu Thr Asn 
145                 150                 155                 160 


Leu Leu Leu Asp Thr Leu Lys Glu Ser Gly Ser Pro Gly His Ser Ala 
                165                 170                 175     


Arg Val Val Thr Val Ser Ser Ala Thr His Tyr Val Ala Glu Leu Asn 
            180                 185                 190         


Met Asp Asp Leu Gln Ser Ser Ala Cys Tyr Ser Pro His Ala Ala Tyr 
        195                 200                 205             


Ala Gln Ser Lys Leu Ala Leu Val Leu Phe Thr Tyr His Leu Gln Arg 
    210                 215                 220                 


Leu Leu Ala Ala Glu Gly Ser His Val Thr Ala Asn Val Val Asp Pro 
225                 230                 235                 240 


Gly Val Val Asn Thr Asp Val Tyr Lys His Val Phe Trp Ala Thr Arg 
                245                 250                 255     


Leu Ala Lys Lys Leu Leu Gly Trp Leu Leu Phe Lys Thr Pro Asp Glu 
            260                 265                 270         


Gly Ala Trp Thr Ser Ile Tyr Ala Ala Val Thr Pro Glu Leu Glu Gly 
        275                 280                 285             


Val Gly Gly His Tyr Leu Tyr Asn Glu Lys Glu Thr Lys Ser Leu His 
    290                 295                 300                 


Val Thr Tyr Asn Gln Lys Leu Gln Gln Gln Leu Trp Ser Lys Ser Cys 
305                 310                 315                 320 


Glu Met Thr Gly Val Leu Asp Val Thr Leu 
                325                 330 


<210>  4216
<211>  232
<212>  PRT
<213>  Homo Sapiens

<400>  4216

Met Ser Pro Leu Ser Ala Ala Arg Ala Ala Leu Arg Val Tyr Ala Val 
1               5                   10                  15      


Gly Ala Ala Val Ile Leu Ala Gln Leu Leu Arg Arg Cys Arg Gly Gly 
            20                  25                  30          


Phe Leu Glu Pro Val Phe Pro Pro Arg Pro Asp Arg Val Ala Ile Val 
        35                  40                  45              


Thr Gly Gly Thr Asp Gly Ile Gly Tyr Ser Thr Ala Lys His Leu Ala 
    50                  55                  60                  


Arg Leu Gly Met His Val Ile Ile Val Glu Phe Leu Tyr Cys Asp Leu 
65                  70                  75                  80  


Ala Ser Met Thr Ser Ile Arg Gln Phe Val Gln Lys Phe Lys Met Lys 
                85                  90                  95      


Lys Ile Pro Leu His Val Leu Ile Asn Asn Ala Gly Val Met Met Val 
            100                 105                 110         


Pro Gln Arg Lys Thr Arg Asp Gly Phe Glu Glu His Phe Gly Leu Asn 
        115                 120                 125             


Tyr Leu Gly His Phe Leu Leu Thr Asn Leu Leu Leu Asp Thr Leu Lys 
    130                 135                 140                 


Glu Ser Gly Ser Pro Gly His Ser Ala Arg Val Val Thr Val Ser Ser 
145                 150                 155                 160 


Ala Thr His Tyr Val Ala Glu Leu Asn Met Asp Asp Leu Gln Ser Ser 
                165                 170                 175     


Ala Cys Tyr Ser Pro His Ala Ala Tyr Ala Gln Ser Lys Leu Ala Leu 
            180                 185                 190         


Val Leu Phe Thr Tyr His Leu Gln Arg Leu Leu Ala Ala Glu Gly Ser 
        195                 200                 205             


His Val Thr Ala Asn Val Val Asp Pro Gly Val Val Asn Thr Asp Val 
    210                 215                 220                 


Tyr Lys His Val Phe Trp Ala Thr 
225                 230         


<210>  4217
<211>  154
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4217

Xaa Pro Ala Arg Pro Gly Pro Thr Leu Pro Ser Pro Arg Val Trp Pro 
1               5                   10                  15      


Pro Arg Leu Ser Arg Val Gly Leu Gln Pro Ser Ser Pro Arg Ala Ala 
            20                  25                  30          


Ala Pro Pro Arg Thr Leu Thr Pro Pro Gly His Gly Arg Gly Pro Gly 
        35                  40                  45              


Gly Ser His Ala Pro Arg Pro Arg His Gln Ala Ala Leu Pro Ala Ala 
    50                  55                  60                  


Cys Gly Arg Pro Val Thr Ala Arg Pro Arg Gln Ala Pro Glu Gly Arg 
65                  70                  75                  80  


Ser Gly Arg Pro Arg Asp Leu Asp Pro Tyr Pro Pro Gln Val Phe Pro 
                85                  90                  95      


Pro Arg Pro Asp Arg Val Ala Ile Val Thr Gly Gly Thr Asp Gly Ile 
            100                 105                 110         


Gly Tyr Ser Thr Ala Lys His Leu Ala Arg Leu Gly Met His Val Ile 
        115                 120                 125             


Ile Ala Gly Asn Asn Asp Ser Lys Ala Lys Gln Val Val Ser Lys Ile 
    130                 135                 140                 


Lys Glu Glu Thr Leu Asn Asp Lys Glu Thr 
145                 150                 


<210>  4218
<211>  1369
<212>  PRT
<213>  Homo Sapiens

<400>  4218

Met Gly Gly Lys Asn Lys Lys His Lys Ala Pro Ala Ala Ala Val Val 
1               5                   10                  15      


Arg Ala Ala Val Ser Ala Ser Arg Ala Lys Ser Ala Glu Ala Gly Ile 
            20                  25                  30          


Ala Gly Glu Ala Gln Ser Lys Lys Pro Val Ser Arg Pro Ala Thr Ala 
        35                  40                  45              


Ala Ala Ala Ala Ala Gly Ser Arg Glu Pro Arg Val Lys Gln Gly Pro 
    50                  55                  60                  


Lys Ile Tyr Ser Phe Asn Ser Thr Asn Asp Ser Ser Gly Pro Ala Asn 
65                  70                  75                  80  


Leu Asp Lys Ser Ile Leu Lys Val Val Ile Asn Asn Lys Leu Glu Gln 
                85                  90                  95      


Arg Ile Ile Gly Val Ile Asn Glu His Lys Lys Gln Asn Asn Asp Lys 
            100                 105                 110         


Gly Met Ile Ser Gly Arg Leu Thr Ala Lys Lys Leu Gln Asp Leu Tyr 
        115                 120                 125             


Met Ala Leu Gln Ala Phe Ser Phe Lys Thr Lys Asp Ile Glu Asp Ala 
    130                 135                 140                 


Met Thr Asn Thr Leu Leu Tyr Gly Gly Asp Leu His Ser Ala Leu Asp 
145                 150                 155                 160 


Trp Leu Cys Leu Asn Leu Ser Asp Asp Ala Leu Pro Glu Gly Phe Ser 
                165                 170                 175     


Gln Glu Phe Glu Glu Gln Gln Pro Lys Ser Arg Pro Lys Phe Gln Ser 
            180                 185                 190         


Pro Gln Ile Gln Ala Thr Ile Ser Pro Pro Leu Gln Pro Lys Thr Lys 
        195                 200                 205             


Thr Tyr Glu Glu Asp Pro Lys Ser Lys Pro Lys Lys Glu Glu Lys Asn 
    210                 215                 220                 


Met Glu Val Asn Met Lys Glu Trp Ile Leu Arg Tyr Ala Glu Gln Gln 
225                 230                 235                 240 


Asn Glu Glu Glu Lys Asn Glu Asn Ser Lys Ser Leu Glu Glu Glu Glu 
                245                 250                 255     


Lys Phe Asp Pro Asn Glu Arg Tyr Leu His Leu Ala Ala Lys Leu Leu 
            260                 265                 270         


Asp Ala Lys Glu Gln Ala Ala Thr Phe Lys Leu Glu Lys Asn Lys Gln 
        275                 280                 285             


Gly Gln Lys Glu Ala Gln Glu Lys Ile Arg Lys Phe Gln Arg Glu Met 
    290                 295                 300                 


Glu Thr Leu Glu Asp His Pro Val Phe Asn Pro Ala Met Lys Ile Ser 
305                 310                 315                 320 


His Gln Gln Asn Glu Arg Lys Lys Pro Pro Val Ala Thr Glu Gly Glu 
                325                 330                 335     


Ser Ala Leu Asn Phe Asn Leu Phe Glu Lys Ser Ala Ala Ala Thr Glu 
            340                 345                 350         


Glu Glu Lys Asp Lys Lys Lys Glu Pro His Asp Val Arg Asn Phe Asp 
        355                 360                 365             


Tyr Thr Ala Arg Ser Trp Thr Gly Lys Ser Pro Lys Gln Phe Leu Ile 
    370                 375                 380                 


Asp Trp Val Arg Lys Asn Leu Pro Lys Ser Pro Asn Pro Ser Phe Glu 
385                 390                 395                 400 


Lys Val Pro Val Gly Arg Tyr Trp Lys Cys Arg Val Arg Val Ile Lys 
                405                 410                 415     


Ser Glu Asp Asp Val Leu Val Val Cys Pro Thr Ile Leu Thr Glu Asp 
            420                 425                 430         


Gly Met Gln Ala Gln His Leu Gly Ala Thr Leu Ala Leu Tyr Arg Leu 
        435                 440                 445             


Val Lys Gly Gln Ser Val His Gln Leu Leu Pro Pro Thr Tyr Arg Asp 
    450                 455                 460                 


Val Trp Leu Glu Trp Ser Asp Ala Glu Lys Lys Arg Glu Glu Leu Asn 
465                 470                 475                 480 


Lys Met Glu Thr Asn Lys Pro Arg Asp Leu Phe Ile Ala Lys Leu Leu 
                485                 490                 495     


Asn Lys Leu Lys Gln Gln Gln Gln Gln Gln Gln Gln His Ser Glu Asn 
            500                 505                 510         


Lys Arg Glu Asn Ser Glu Asp Pro Glu Glu Ser Trp Glu Asn Leu Val 
        515                 520                 525             


Ser Asp Glu Asp Phe Ser Ala Leu Ser Leu Glu Ser Ala Asn Val Glu 
    530                 535                 540                 


Asp Leu Glu Pro Val Arg Asn Leu Phe Arg Lys Leu Gln Ser Thr Pro 
545                 550                 555                 560 


Lys Tyr Gln Lys Leu Leu Lys Glu Arg Gln Gln Leu Pro Val Phe Lys 
                565                 570                 575     


His Arg Asp Ser Ile Val Glu Thr Leu Lys Arg His Arg Val Val Val 
            580                 585                 590         


Val Ala Gly Glu Thr Gly Ser Gly Lys Ser Thr Gln Val Pro His Phe 
        595                 600                 605             


Leu Leu Glu Asp Leu Leu Leu Asn Glu Trp Glu Ala Ser Lys Cys Asn 
    610                 615                 620                 


Ile Val Cys Thr Gln Pro Arg Arg Ile Ser Ala Val Ser Leu Ala Asn 
625                 630                 635                 640 


Arg Val Cys Asp Glu Leu Gly Cys Glu Asn Gly Pro Gly Gly Arg Asn 
                645                 650                 655     


Ser Leu Cys Gly Tyr Gln Ile Arg Met Glu Ser Arg Ala Cys Glu Ser 
            660                 665                 670         


Thr Arg Leu Leu Tyr Cys Thr Thr Gly Val Leu Leu Arg Lys Leu Gln 
        675                 680                 685             


Glu Asp Gly Leu Leu Ser Asn Val Ser His Val Ile Val Asp Glu Val 
    690                 695                 700                 


His Glu Arg Ser Val Gln Ser Asp Phe Leu Leu Ile Ile Leu Lys Glu 
705                 710                 715                 720 


Ile Leu Gln Lys Arg Ser Asp Leu His Leu Ile Leu Met Ser Ala Thr 
                725                 730                 735     


Val Asp Ser Glu Lys Phe Ser Thr Tyr Phe Thr His Cys Pro Ile Leu 
            740                 745                 750         


Arg Ile Ser Gly Arg Ser Tyr Pro Val Glu Val Phe His Leu Glu Asp 
        755                 760                 765             


Ile Ile Glu Glu Thr Gly Phe Val Leu Glu Lys Asp Ser Glu Tyr Cys 
    770                 775                 780                 


Gln Lys Phe Leu Glu Glu Glu Glu Glu Val Thr Ile Asn Val Thr Ser 
785                 790                 795                 800 


Lys Ala Gly Gly Ile Lys Lys Tyr Gln Glu Tyr Ile Pro Val Gln Thr 
                805                 810                 815     


Gly Ala His Ala Asp Leu Asn Pro Phe Tyr Gln Lys Tyr Ser Ser Arg 
            820                 825                 830         


Thr Gln His Ala Ile Leu Tyr Met Asn Pro His Lys Ile Asn Leu Asp 
        835                 840                 845             


Leu Ile Leu Glu Leu Leu Ala Tyr Leu Asp Lys Ser Pro Gln Phe Arg 
    850                 855                 860                 


Asn Ile Glu Gly Ala Val Leu Ile Phe Leu Pro Gly Leu Ala His Ile 
865                 870                 875                 880 


Gln Gln Leu Tyr Asp Leu Leu Ser Asn Asp Arg Arg Phe Tyr Ser Glu 
                885                 890                 895     


Arg Tyr Lys Val Ile Ala Leu His Ser Ile Leu Ser Thr Gln Asp Gln 
            900                 905                 910         


Ala Ala Ala Phe Thr Leu Pro Pro Pro Gly Val Arg Lys Ile Val Leu 
        915                 920                 925             


Ala Thr Asn Ile Ala Glu Thr Gly Ile Thr Ile Pro Asp Val Val Phe 
    930                 935                 940                 


Val Ile Asp Thr Gly Arg Thr Lys Glu Asn Lys Tyr His Glu Ser Ser 
945                 950                 955                 960 


Gln Met Ser Ser Leu Val Glu Thr Phe Val Ser Lys Ala Ser Ala Leu 
                965                 970                 975     


Gln Arg Gln Gly Arg Ala Gly Arg Val Arg Asp Gly Phe Cys Phe Arg 
            980                 985                 990         


Met Tyr Thr Arg Glu Arg Phe Glu  Gly Phe Met Asp Tyr  Ser Val Pro 
        995                 1000                 1005             


Glu Ile  Leu Arg Val Pro Leu  Glu Glu Leu Cys Leu  His Ile Met 
    1010                 1015                 1020             


Lys Cys  Asn Leu Gly Ser Pro  Glu Asp Phe Leu Ser  Lys Ala Leu 
    1025                 1030                 1035             


Asp Pro  Pro Gln Leu Gln Val  Ile Ser Asn Ala Met  Asn Leu Leu 
    1040                 1045                 1050             


Arg Lys  Ile Gly Ala Cys Glu  Leu Asn Glu Pro Lys  Leu Thr Pro 
    1055                 1060                 1065             


Leu Gly  Gln His Leu Ala Ala  Leu Pro Val Asn Val  Lys Ile Gly 
    1070                 1075                 1080             


Lys Met  Leu Ile Phe Gly Ala  Ile Phe Gly Cys Leu  Asp Pro Val 
    1085                 1090                 1095             


Ala Thr  Leu Ala Ala Val Met  Thr Glu Lys Ser Pro  Phe Thr Thr 
    1100                 1105                 1110             


Pro Ile  Gly Arg Lys Asp Glu  Ala Asp Leu Ala Lys  Ser Ala Leu 
    1115                 1120                 1125             


Ala Met  Ala Asp Ser Asp His  Leu Thr Ile Tyr Asn  Ala Tyr Leu 
    1130                 1135                 1140             


Gly Trp  Lys Lys Ala Arg Gln  Glu Gly Gly Tyr Arg  Ser Glu Ile 
    1145                 1150                 1155             


Thr Tyr  Cys Arg Arg Asn Phe  Leu Asn Arg Thr Ser  Leu Leu Thr 
    1160                 1165                 1170             


Leu Glu  Asp Val Lys Gln Glu  Leu Ile Lys Leu Val  Lys Ala Ala 
    1175                 1180                 1185             


Gly Phe  Ser Ser Ser Thr Thr  Ser Thr Ser Trp Glu  Gly Asn Arg 
    1190                 1195                 1200             


Ala Ser  Gln Thr Leu Ser Phe  Gln Glu Ile Ala Leu  Leu Lys Ala 
    1205                 1210                 1215             


Val Leu  Val Ala Gly Leu Tyr  Asp Asn Val Gly Lys  Ile Ile Tyr 
    1220                 1225                 1230             


Thr Lys  Ser Val Asp Val Thr  Glu Lys Leu Ala Cys  Ile Val Glu 
    1235                 1240                 1245             


Thr Ala  Gln Gly Lys Ala Gln  Val His Pro Ser Ser  Val Asn Arg 
    1250                 1255                 1260             


Asp Leu  Gln Thr His Gly Trp  Leu Leu Tyr Gln Glu  Lys Ile Arg 
    1265                 1270                 1275             


Tyr Ala  Arg Val Tyr Leu Arg  Glu Thr Thr Leu Ile  Thr Pro Phe 
    1280                 1285                 1290             


Pro Val  Leu Leu Phe Gly Gly  Asp Ile Glu Val Gln  His Arg Glu 
    1295                 1300                 1305             


Arg Leu  Leu Ser Ile Asp Gly  Trp Ile Tyr Phe Gln  Ala Pro Val 
    1310                 1315                 1320             


Lys Ile  Ala Val Ile Phe Lys  Gln Leu Arg Val Leu  Ile Asp Ser 
    1325                 1330                 1335             


Val Leu  Arg Lys Lys Leu Glu  Asn Pro Lys Met Ser  Leu Glu Asn 
    1340                 1345                 1350             


Asp Lys  Ile Leu Gln Ile Ile  Thr Glu Leu Ile Lys  Thr Glu Asn 
    1355                 1360                 1365             


Asn 
    


<210>  4219
<211>  1370
<212>  PRT
<213>  Homo Sapiens

<400>  4219

Met Gly Gly Lys Asn Lys Lys His Lys Ala Pro Ala Ala Ala Val Val 
1               5                   10                  15      


Arg Ala Ala Val Ser Ala Ser Arg Ala Lys Ser Ala Glu Ala Gly Ile 
            20                  25                  30          


Ala Gly Glu Ala Gln Ser Lys Lys Pro Val Ser Arg Pro Ala Thr Ala 
        35                  40                  45              


Ala Ala Ala Ala Ala Gly Ser Arg Glu Pro Arg Val Lys Gln Gly Pro 
    50                  55                  60                  


Lys Ile Tyr Ser Phe Asn Ser Thr Asn Asp Ser Ser Gly Pro Ala Asn 
65                  70                  75                  80  


Leu Asp Lys Ser Ile Leu Lys Val Val Ile Asn Asn Lys Leu Glu Gln 
                85                  90                  95      


Arg Ile Ile Gly Val Ile Asn Glu His Lys Lys Gln Asn Asn Asp Lys 
            100                 105                 110         


Gly Met Ile Ser Gly Arg Leu Thr Ala Lys Lys Leu Gln Asp Leu Tyr 
        115                 120                 125             


Met Ala Leu Gln Ala Phe Ser Phe Lys Thr Lys Asp Ile Glu Asp Ala 
    130                 135                 140                 


Met Thr Asn Thr Leu Leu Tyr Gly Gly Asp Leu His Ser Ala Leu Asp 
145                 150                 155                 160 


Trp Leu Cys Leu Asn Leu Ser Asp Asp Ala Leu Pro Glu Gly Phe Ser 
                165                 170                 175     


Gln Glu Phe Glu Glu Gln Gln Pro Lys Ser Arg Pro Lys Phe Gln Ser 
            180                 185                 190         


Pro Gln Ile Gln Ala Thr Ile Ser Pro Pro Leu Gln Pro Lys Thr Lys 
        195                 200                 205             


Thr Tyr Glu Glu Asp Pro Lys Ser Lys Pro Lys Lys Glu Glu Lys Asn 
    210                 215                 220                 


Met Glu Val Asn Met Lys Glu Trp Ile Leu Arg Tyr Ala Glu Gln Gln 
225                 230                 235                 240 


Asn Glu Glu Glu Lys Asn Glu Asn Ser Lys Ser Leu Glu Glu Glu Glu 
                245                 250                 255     


Lys Phe Asp Pro Asn Glu Arg Tyr Leu His Leu Ala Ala Lys Leu Leu 
            260                 265                 270         


Asp Ala Lys Glu Gln Ala Ala Thr Phe Lys Leu Glu Lys Asn Lys Gln 
        275                 280                 285             


Gly Gln Lys Glu Ala Gln Glu Lys Ile Arg Lys Phe Gln Arg Glu Met 
    290                 295                 300                 


Glu Thr Leu Glu Asp His Pro Val Phe Asn Pro Ala Met Lys Ile Ser 
305                 310                 315                 320 


His Gln Gln Asn Glu Arg Lys Lys Pro Pro Val Ala Thr Glu Gly Glu 
                325                 330                 335     


Ser Ala Leu Asn Phe Asn Leu Phe Glu Lys Ser Ala Ala Ala Thr Glu 
            340                 345                 350         


Glu Glu Lys Gly Lys Lys Lys Glu Pro His Asp Val Arg Asn Phe Asp 
        355                 360                 365             


Tyr Thr Ala Arg Ser Trp Thr Gly Lys Ser Pro Lys Gln Phe Leu Ile 
    370                 375                 380                 


Asp Trp Val Arg Lys Asn Leu Pro Lys Ser Pro Asn Pro Ser Phe Glu 
385                 390                 395                 400 


Lys Val Pro Val Gly Arg Tyr Trp Lys Cys Arg Val Arg Val Ile Lys 
                405                 410                 415     


Ser Glu Asp Asp Val Leu Val Val Cys Pro Thr Ile Leu Thr Glu Asp 
            420                 425                 430         


Gly Met Gln Ala Gln His Leu Gly Ala Thr Leu Ala Leu Tyr Arg Leu 
        435                 440                 445             


Val Lys Gly Gln Ser Val His Gln Leu Leu Pro Pro Thr Tyr Arg Asp 
    450                 455                 460                 


Val Trp Leu Glu Trp Ser Asp Ala Glu Lys Lys Arg Glu Glu Leu Asn 
465                 470                 475                 480 


Lys Met Glu Thr Asn Lys Pro Arg Asp Leu Phe Ile Ala Lys Leu Leu 
                485                 490                 495     


Asn Lys Leu Lys Gln Gln Gln Gln Gln Gln Gln Gln His Ser Glu Asn 
            500                 505                 510         


Lys Arg Glu Asn Ser Glu Asp Pro Glu Glu Ser Trp Glu Asn Leu Val 
        515                 520                 525             


Ser Asp Glu Asp Phe Ser Ala Leu Ser Leu Glu Ser Ala Asn Val Glu 
    530                 535                 540                 


Asp Leu Glu Pro Val Arg Asn Leu Phe Arg Lys Leu Gln Ser Thr Pro 
545                 550                 555                 560 


Lys Tyr Gln Lys Leu Leu Lys Glu Arg Gln Gln Leu Pro Val Phe Lys 
                565                 570                 575     


His Arg Asp Ser Ile Val Glu Thr Leu Lys Arg His Arg Val Val Val 
            580                 585                 590         


Val Ala Gly Glu Thr Gly Ser Gly Lys Ser Thr Gln Val Pro His Phe 
        595                 600                 605             


Leu Leu Glu Asp Leu Leu Leu Asn Glu Trp Glu Ala Ser Lys Cys Asn 
    610                 615                 620                 


Ile Val Cys Thr Gln Pro Arg Arg Ile Ser Ala Val Ser Leu Ala Asn 
625                 630                 635                 640 


Arg Val Cys Asp Glu Leu Gly Cys Glu Asn Gly Pro Gly Gly Arg Asn 
                645                 650                 655     


Ser Leu Cys Gly Tyr Gln Ile Arg Met Glu Ser Arg Ala Cys Glu Ser 
            660                 665                 670         


Thr Arg Leu Leu Tyr Cys Thr Thr Gly Val Leu Leu Arg Lys Leu Gln 
        675                 680                 685             


Glu Asp Gly Leu Leu Ser Asn Val Ser His Val Ile Val Asp Glu Val 
    690                 695                 700                 


His Glu Arg Ser Val Gln Ser Asp Phe Leu Leu Ile Ile Leu Lys Glu 
705                 710                 715                 720 


Ile Leu Gln Lys Arg Ser Asp Leu His Leu Ile Leu Met Ser Ala Thr 
                725                 730                 735     


Val Asp Ser Glu Lys Phe Ser Thr Tyr Phe Thr His Cys Pro Ile Leu 
            740                 745                 750         


Arg Ile Ser Gly Arg Ser Tyr Pro Val Glu Val Phe His Leu Glu Asp 
        755                 760                 765             


Ile Ile Glu Glu Thr Gly Phe Val Leu Glu Lys Asp Ser Glu Tyr Cys 
    770                 775                 780                 


Gln Lys Phe Leu Glu Glu Glu Glu Glu Val Thr Ile Asn Val Thr Ser 
785                 790                 795                 800 


Lys Ala Gly Gly Ile Lys Lys Tyr Gln Glu Tyr Ile Pro Val Gln Thr 
                805                 810                 815     


Gly Ala His Ala Asp Leu Asn Pro Phe Tyr Gln Lys Tyr Ser Ser Arg 
            820                 825                 830         


Thr Gln His Ala Ile Leu Tyr Met Asn Pro His Lys Ile Asn Leu Asp 
        835                 840                 845             


Leu Ile Leu Glu Leu Leu Ala Tyr Leu Asp Lys Ser Pro Gln Phe Arg 
    850                 855                 860                 


Asn Ile Glu Gly Ala Val Leu Ile Phe Leu Pro Gly Leu Ala His Ile 
865                 870                 875                 880 


Gln Gln Leu Tyr Asp Leu Leu Ser Asn Asp Arg Arg Phe Tyr Ser Glu 
                885                 890                 895     


Arg Tyr Lys Val Ile Ala Leu His Ser Ile Leu Ser Thr Gln Asp Gln 
            900                 905                 910         


Ala Ala Ala Phe Thr Leu Pro Pro Pro Gly Val Arg Lys Ile Val Leu 
        915                 920                 925             


Ala Thr Asn Ile Ala Glu Thr Gly Ile Thr Ile Pro Asp Val Val Phe 
    930                 935                 940                 


Val Ile Asp Thr Gly Arg Thr Lys Glu Asn Lys Tyr His Glu Ser Ser 
945                 950                 955                 960 


Gln Met Ser Ser Leu Val Glu Thr Phe Val Ser Lys Ala Ser Ala Leu 
                965                 970                 975     


Gln Arg Gln Gly Arg Ala Gly Arg Val Arg Asp Gly Phe Cys Phe Arg 
            980                 985                 990         


Met Tyr Thr Arg Glu Arg Phe Glu  Gly Phe Met Asp Tyr  Ser Val Pro 
        995                 1000                 1005             


Glu Ile  Leu Arg Val Pro Leu  Glu Glu Leu Cys Leu  His Ile Met 
    1010                 1015                 1020             


Lys Cys  Asn Leu Gly Ser Pro  Glu Asp Phe Leu Ser  Lys Ala Leu 
    1025                 1030                 1035             


Asp Pro  Pro Gln Leu Gln Val  Ile Ser Asn Ala Met  Asn Leu Leu 
    1040                 1045                 1050             


Arg Lys  Ile Gly Ala Cys Glu  Leu Asn Glu Pro Lys  Leu Thr Pro 
    1055                 1060                 1065             


Leu Gly  Gln His Leu Ala Ala  Leu Pro Val Asn Val  Lys Ile Gly 
    1070                 1075                 1080             


Lys Met  Leu Ile Phe Gly Ala  Ile Phe Gly Cys Leu  Asp Pro Val 
    1085                 1090                 1095             


Ala Thr  Leu Ala Ala Val Met  Thr Glu Lys Ser Pro  Phe Thr Thr 
    1100                 1105                 1110             


Pro Ile  Gly Arg Lys Asp Glu  Ala Asp Leu Ala Lys  Ser Ala Leu 
    1115                 1120                 1125             


Ala Met  Ala Asp Ser Asp His  Leu Thr Ile Tyr Asn  Ala Tyr Leu 
    1130                 1135                 1140             


Gly Trp  Lys Lys Ala Arg Gln  Glu Gly Gly Tyr Arg  Ser Glu Ile 
    1145                 1150                 1155             


Thr Tyr  Cys Arg Arg Asn Phe  Leu Asn Arg Thr Ser  Leu Leu Thr 
    1160                 1165                 1170             


Leu Glu  Asp Val Lys Gln Glu  Leu Ile Lys Leu Val  Lys Ala Ala 
    1175                 1180                 1185             


Gly Phe  Ser Ser Ser Thr Thr  Ser Thr Ser Trp Glu  Gly Asn Arg 
    1190                 1195                 1200             


Ala Ser  Gln Thr Leu Ser Phe  Gln Glu Ile Ala Leu  Leu Lys Ala 
    1205                 1210                 1215             


Val Leu  Val Ala Gly Leu Tyr  Asp Asn Val Gly Lys  Ile Ile Tyr 
    1220                 1225                 1230             


Thr Lys  Ser Val Asp Val Thr  Glu Lys Leu Ala Cys  Ile Val Glu 
    1235                 1240                 1245             


Thr Ala  Gln Gly Lys Ala Gln  Val His Pro Ser Ser  Val Asn Arg 
    1250                 1255                 1260             


Asp Leu  Gln Thr His Gly Trp  Leu Leu Tyr Gln Glu  Lys Ile Arg 
    1265                 1270                 1275             


Tyr Ala  Arg Val Tyr Leu Arg  Glu Thr Thr Leu Ile  Thr Pro Phe 
    1280                 1285                 1290             


Pro Val  Leu Leu Phe Gly Gly  Asp Ile Glu Val Gln  His Arg Glu 
    1295                 1300                 1305             


Arg Leu  Leu Ser Ile Asp Gly  Trp Ile Tyr Phe Gln  Ala Pro Val 
    1310                 1315                 1320             


Lys Ile  Ala Val Ile Phe Lys  Gln Leu Arg Val Leu  Ile Asp Ser 
    1325                 1330                 1335             


Val Leu  Arg Lys Lys Leu Glu  Asn Pro Lys Met Ser  Leu Glu Asn 
    1340                 1345                 1350             


Asp Lys  Ile Leu Gln Ile Ile  Thr Glu Leu Ile Lys  Thr Glu Asn 
    1355                 1360                 1365             


Asn Asn  
    1370 


<210>  4220
<211>  160
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4220

Xaa Arg Pro Arg Trp Ser Gly Pro Pro Cys Leu Leu Pro Glu Pro Asn 
1               5                   10                  15      


Leu Pro Arg Leu Glu Leu Pro Gly Arg Pro Lys Ala Arg Ser Gln Cys 
            20                  25                  30          


Pro Gly Arg Pro Pro Leu Pro Leu Pro Leu Pro Ala Pro Gly Ser Pro 
        35                  40                  45              


Val Ser Ser Lys Val Val Ile Asn Asn Lys Leu Glu Gln Arg Ile Ile 
    50                  55                  60                  


Gly Val Ile Asn Glu His Lys Lys Gln Asn Asn Asp Lys Gly Met Ile 
65                  70                  75                  80  


Ser Gly Arg Leu Thr Ala Lys Lys Leu Gln Asp Leu Tyr Met Ala Leu 
                85                  90                  95      


Gln Ala Phe Ser Phe Lys Thr Lys Asp Ile Glu Asp Ala Met Thr Asn 
            100                 105                 110         


Thr Leu Leu Tyr Gly Gly Asp Leu His Ser Ala Leu Asp Trp Leu Cys 
        115                 120                 125             


Leu Asn Leu Ser Asp Asp Ala Leu Pro Glu Gly Phe Ser Gln Glu Phe 
    130                 135                 140                 


Glu Glu Gln Gln Pro Lys Ser Arg Pro Lys Phe Gln Ser Pro Gln Ile 
145                 150                 155                 160 


<210>  4221
<211>  1222
<212>  PRT
<213>  Homo Sapiens

<400>  4221

Met Ala Ala Ala Arg Arg Leu Met Ala Leu Ala Ala Gly Ile Ser Pro 
1               5                   10                  15      


Arg Leu Gln Pro Leu Gly Pro Arg Ala Ala Gly Arg Gln Gly Arg Ser 
            20                  25                  30          


Arg Gly Phe Ser Ser Ser Cys Ala His Pro Asp His Thr Lys Glu Ala 
        35                  40                  45              


Ala Glu Ala Glu Ser Gly Met Ala Pro Gly Gly Pro Gly Glu Gly Asp 
    50                  55                  60                  


Gly Ser Leu Val Asn Ala Ser Arg Asp Leu Leu Lys Glu Phe Pro Gln 
65                  70                  75                  80  


Pro Lys Asn Leu Leu Asn Ser Val Ile Gly Arg Ala Leu Gly Ile Ser 
                85                  90                  95      


His Ala Lys Asp Lys Leu Val Tyr Val His Thr Asn Gly Pro Lys Lys 
            100                 105                 110         


Lys Lys Val Thr Leu His Ile Lys Trp Pro Lys Ser Val Glu Val Glu 
        115                 120                 125             


Gly Tyr Gly Ser Lys Lys Ile Asp Ala Glu Arg Gln Ala Ala Ala Ala 
    130                 135                 140                 


Ala Cys Gln Leu Phe Lys Gly Trp Gly Leu Leu Gly Pro Arg Asn Glu 
145                 150                 155                 160 


Leu Phe Asp Ala Ala Lys Tyr Arg Val Leu Ala Asp Arg Phe Gly Ser 
                165                 170                 175     


Pro Ala Asp Ser Trp Trp Arg Pro Glu Pro Thr Met Pro Pro Thr Ser 
            180                 185                 190         


Trp Arg Gln Leu Asn Pro Glu Ser Ile Arg Pro Gly Gly Pro Gly Gly 
        195                 200                 205             


Leu Ser Arg Ser Leu Gly Arg Glu Glu Glu Glu Asp Glu Glu Glu Glu 
    210                 215                 220                 


Leu Glu Glu Gly Thr Ile Asp Val Thr Asp Phe Leu Ser Met Thr Gln 
225                 230                 235                 240 


Gln Asp Ser His Ala Pro Leu Arg Asp Ser Arg Gly Ser Ser Phe Glu 
                245                 250                 255     


Met Thr Asp Asp Asp Ser Ala Ile Arg Ala Leu Thr Gln Phe Pro Leu 
            260                 265                 270         


Pro Lys Asn Leu Leu Ala Lys Val Ile Gln Ile Ala Thr Ser Ser Ser 
        275                 280                 285             


Thr Ala Lys Asn Leu Met Gln Phe His Thr Val Gly Thr Lys Thr Lys 
    290                 295                 300                 


Leu Ser Thr Leu Thr Leu Leu Trp Pro Cys Pro Met Thr Phe Val Ala 
305                 310                 315                 320 


Lys Gly Arg Arg Lys Ala Glu Ala Glu Asn Lys Ala Ala Ala Leu Ala 
                325                 330                 335     


Cys Lys Lys Leu Lys Ser Leu Gly Leu Val Asp Arg Asn Asn Glu Pro 
            340                 345                 350         


Leu Thr His Ala Met Tyr Asn Leu Ala Ser Leu Arg Glu Leu Gly Glu 
        355                 360                 365             


Thr Gln Arg Arg Pro Cys Thr Ile Gln Val Pro Glu Pro Ile Leu Arg 
    370                 375                 380                 


Lys Ile Glu Thr Phe Leu Asn His Tyr Pro Val Glu Ser Ser Trp Ile 
385                 390                 395                 400 


Ala Pro Glu Leu Arg Leu Gln Ser Asp Asp Ile Leu Pro Leu Gly Lys 
                405                 410                 415     


Asp Ser Gly Pro Leu Ser Asp Pro Ile Thr Gly Lys Pro Tyr Val Pro 
            420                 425                 430         


Leu Leu Glu Ala Glu Glu Val Arg Leu Ser Gln Ser Leu Leu Glu Leu 
        435                 440                 445             


Trp Arg Arg Arg Gly Pro Val Trp Gln Glu Ala Pro Gln Leu Pro Val 
    450                 455                 460                 


Asp Pro His Arg Asp Thr Ile Leu Asn Ala Ile Glu Gln His Pro Val 
465                 470                 475                 480 


Val Val Ile Ser Gly Asp Thr Gly Cys Gly Lys Thr Thr Arg Ile Pro 
                485                 490                 495     


Gln Leu Leu Leu Glu Arg Tyr Val Thr Glu Gly Arg Gly Ala Arg Cys 
            500                 505                 510         


Asn Val Ile Ile Thr Gln Pro Arg Arg Ile Ser Ala Val Ser Val Ala 
        515                 520                 525             


Gln Arg Val Ser His Glu Leu Gly Pro Ser Leu Arg Arg Asn Val Gly 
    530                 535                 540                 


Phe Gln Val Arg Leu Glu Ser Lys Pro Pro Ser Arg Gly Gly Ala Leu 
545                 550                 555                 560 


Leu Phe Cys Thr Val Gly Ile Leu Leu Arg Lys Leu Gln Ser Asn Pro 
                565                 570                 575     


Ser Leu Glu Gly Val Ser His Val Ile Val Asp Glu Val His Glu Arg 
            580                 585                 590         


Asp Val Asn Thr Asp Phe Leu Leu Ile Leu Leu Lys Gly Leu Gln Arg 
        595                 600                 605             


Leu Asn Pro Ala Leu Arg Leu Val Leu Met Ser Ala Thr Gly Asp Asn 
    610                 615                 620                 


Glu Arg Phe Ser Arg Tyr Phe Gly Gly Cys Pro Val Ile Lys Val Pro 
625                 630                 635                 640 


Gly Phe Met Tyr Pro Val Lys Glu His Tyr Leu Glu Asp Ile Leu Ala 
                645                 650                 655     


Lys Leu Gly Lys His Gln Tyr Leu His Arg His Arg His His Glu Ser 
            660                 665                 670         


Glu Asp Glu Cys Ala Leu Asp Leu Asp Leu Val Thr Asp Leu Val Leu 
        675                 680                 685             


His Ile Asp Ala Arg Gly Glu Pro Gly Gly Ile Leu Cys Phe Leu Pro 
    690                 695                 700                 


Gly Trp Gln Glu Ile Lys Gly Val Gln Gln Arg Leu Gln Glu Ala Leu 
705                 710                 715                 720 


Gly Met His Glu Ser Lys Tyr Leu Ile Leu Pro Val His Ser Asn Ile 
                725                 730                 735     


Pro Met Met Asp Gln Lys Ala Ile Phe Gln Gln Pro Pro Val Gly Val 
            740                 745                 750         


Arg Lys Ile Val Leu Ala Thr Asn Ile Ala Glu Thr Ser Ile Thr Ile 
        755                 760                 765             


Asn Asp Ile Val His Val Val Asp Ser Gly Leu His Lys Glu Glu Arg 
    770                 775                 780                 


Tyr Asp Leu Lys Thr Lys Val Ser Cys Leu Glu Thr Val Trp Val Ser 
785                 790                 795                 800 


Arg Ala Asn Val Ile Gln Arg Arg Gly Arg Ala Gly Arg Cys Gln Ser 
                805                 810                 815     


Gly Phe Ala Tyr His Leu Phe Pro Arg Ser Arg Leu Glu Lys Met Val 
            820                 825                 830         


Pro Phe Gln Val Pro Glu Ile Leu Arg Thr Pro Leu Glu Asn Leu Val 
        835                 840                 845             


Leu Gln Ala Lys Ile His Met Pro Glu Lys Thr Ala Val Glu Phe Leu 
    850                 855                 860                 


Ser Lys Ala Val Asp Ser Pro Asn Ile Lys Ala Val Asp Glu Ala Val 
865                 870                 875                 880 


Ile Leu Leu Gln Glu Ile Gly Val Leu Asp Gln Arg Glu Tyr Leu Thr 
                885                 890                 895     


Thr Leu Gly Gln Arg Leu Ala His Ile Ser Thr Asp Pro Arg Leu Ala 
            900                 905                 910         


Lys Ala Ile Val Leu Ala Ala Ile Phe Arg Cys Leu His Pro Leu Leu 
        915                 920                 925             


Val Val Val Ser Cys Leu Thr Arg Asp Pro Phe Ser Ser Ser Leu Gln 
    930                 935                 940                 


Asn Arg Ala Glu Val Asp Lys Val Lys Ala Leu Leu Ser His Asp Ser 
945                 950                 955                 960 


Gly Ser Asp His Leu Ala Phe Val Arg Ala Val Ala Gly Trp Glu Glu 
                965                 970                 975     


Val Leu Arg Trp Gln Asp Arg Ser Ser Arg Glu Asn Tyr Leu Glu Glu 
            980                 985                 990         


Asn Leu Leu Tyr Ala Pro Ser Leu  Arg Phe Ile His Gly  Leu Ile Lys 
        995                 1000                 1005             


Gln Phe  Ser Glu Asn Ile Tyr  Glu Ala Phe Leu Val  Gly Lys Pro 
    1010                 1015                 1020             


Ser Asp  Cys Thr Leu Ala Ser  Ala Gln Cys Asn Glu  Tyr Ser Glu 
    1025                 1030                 1035             


Glu Glu  Glu Leu Val Lys Gly  Val Leu Met Ala Gly  Leu Tyr Pro 
    1040                 1045                 1050             


Asn Leu  Ile Gln Val Arg Gln  Gly Lys Val Thr Arg  Gln Gly Lys 
    1055                 1060                 1065             


Phe Lys  Pro Asn Ser Val Thr  Tyr Arg Thr Lys Ser  Gly Asn Ile 
    1070                 1075                 1080             


Leu Leu  His Lys Ser Thr Ile  Asn Arg Glu Ala Thr  Arg Leu Arg 
    1085                 1090                 1095             


Ser Arg  Trp Leu Thr Tyr Phe  Met Ala Val Lys Ser  Asn Gly Ser 
    1100                 1105                 1110             


Val Phe  Val Arg Asp Ser Ser  Gln Val His Pro Leu  Ala Val Leu 
    1115                 1120                 1125             


Leu Leu  Thr Asp Gly Asp Val  His Ile Arg Asp Asp  Gly Arg Arg 
    1130                 1135                 1140             


Ala Thr  Ile Ser Leu Ser Asp  Ser Asp Leu Leu Arg  Leu Glu Gly 
    1145                 1150                 1155             


Asp Ser  Arg Thr Val Arg Leu  Leu Lys Glu Leu Arg  Arg Ala Leu 
    1160                 1165                 1170             


Gly Arg  Met Val Glu Arg Ser  Leu Arg Ser Glu Leu  Ala Ala Leu 
    1175                 1180                 1185             


Pro Pro  Ser Val Gln Glu Glu  His Gly Gln Leu Leu  Ala Leu Leu 
    1190                 1195                 1200             


Ala Glu  Leu Leu Arg Gly Pro  Cys Gly Ser Phe Asp  Val Arg Lys 
    1205                 1210                 1215             


Thr Ala  Asp Asp 
    1220         


<210>  4222
<211>  1155
<212>  PRT
<213>  Homo Sapiens

<400>  4222

Met Ala Ala Ser Arg Asp Leu Leu Lys Glu Phe Pro Gln Pro Lys Asn 
1               5                   10                  15      


Leu Leu Asn Ser Val Ile Gly Arg Ala Leu Gly Ile Ser His Ala Lys 
            20                  25                  30          


Asp Lys Leu Val Tyr Val His Thr Asn Gly Pro Lys Lys Lys Lys Val 
        35                  40                  45              


Thr Leu His Ile Lys Trp Pro Lys Ser Val Glu Val Glu Gly Tyr Gly 
    50                  55                  60                  


Ser Lys Lys Ile Asp Ala Glu Arg Gln Ala Ala Ala Ala Ala Cys Gln 
65                  70                  75                  80  


Leu Phe Lys Gly Trp Gly Leu Leu Gly Pro Arg Asn Glu Leu Phe Asp 
                85                  90                  95      


Ala Ala Lys Tyr Arg Val Leu Ala Asp Arg Phe Gly Ser Pro Ala Asp 
            100                 105                 110         


Ser Trp Trp Arg Pro Glu Pro Thr Met Pro Pro Thr Ser Trp Arg Gln 
        115                 120                 125             


Leu Asn Pro Glu Ser Ile Arg Pro Gly Gly Pro Gly Gly Leu Ser Arg 
    130                 135                 140                 


Ser Leu Gly Arg Glu Glu Glu Glu Asp Glu Glu Glu Glu Leu Glu Glu 
145                 150                 155                 160 


Gly Thr Ile Asp Val Thr Asp Phe Leu Ser Met Thr Gln Gln Asp Ser 
                165                 170                 175     


His Ala Pro Leu Arg Asp Ser Arg Gly Ser Ser Phe Glu Met Thr Asp 
            180                 185                 190         


Asp Asp Ser Ala Ile Arg Ala Leu Thr Gln Phe Pro Leu Pro Lys Asn 
        195                 200                 205             


Leu Leu Ala Lys Val Ile Gln Ile Ala Thr Ser Ser Ser Thr Ala Lys 
    210                 215                 220                 


Asn Leu Met Gln Phe His Thr Val Gly Thr Lys Thr Lys Leu Ser Thr 
225                 230                 235                 240 


Leu Thr Leu Leu Trp Pro Cys Pro Met Thr Phe Val Ala Lys Gly Arg 
                245                 250                 255     


Arg Lys Ala Glu Ala Glu Asn Lys Ala Ala Ala Leu Ala Cys Lys Lys 
            260                 265                 270         


Leu Lys Ser Leu Gly Leu Val Asp Arg Asn Asn Glu Pro Leu Thr His 
        275                 280                 285             


Ala Met Tyr Asn Leu Ala Ser Leu Arg Glu Leu Gly Glu Thr Gln Arg 
    290                 295                 300                 


Arg Pro Cys Thr Ile Gln Val Pro Glu Pro Ile Leu Arg Lys Ile Glu 
305                 310                 315                 320 


Thr Phe Leu Asn His Tyr Pro Val Glu Ser Ser Trp Ile Ala Pro Glu 
                325                 330                 335     


Leu Arg Leu Gln Ser Asp Asp Ile Leu Pro Leu Gly Lys Asp Ser Gly 
            340                 345                 350         


Pro Leu Ser Asp Pro Ile Thr Gly Lys Pro Tyr Val Pro Leu Leu Glu 
        355                 360                 365             


Ala Glu Glu Val Arg Leu Ser Gln Ser Leu Leu Glu Leu Trp Arg Arg 
    370                 375                 380                 


Arg Gly Pro Val Trp Gln Glu Ala Pro Gln Leu Pro Val Asp Pro His 
385                 390                 395                 400 


Arg Asp Thr Ile Leu Asn Ala Ile Glu Gln His Pro Val Val Val Ile 
                405                 410                 415     


Ser Gly Asp Thr Gly Cys Gly Lys Thr Thr Arg Ile Pro Gln Leu Leu 
            420                 425                 430         


Leu Glu Arg Tyr Val Thr Glu Gly Arg Gly Ala Arg Cys Asn Val Ile 
        435                 440                 445             


Ile Thr Gln Pro Arg Arg Ile Ser Ala Val Ser Val Ala Gln Arg Val 
    450                 455                 460                 


Ser His Glu Leu Gly Pro Ser Leu Arg Arg Asn Val Gly Phe Gln Val 
465                 470                 475                 480 


Arg Leu Glu Ser Lys Pro Pro Ser Arg Gly Gly Ala Leu Leu Phe Cys 
                485                 490                 495     


Thr Val Gly Ile Leu Leu Arg Lys Leu Gln Ser Asn Pro Ser Leu Glu 
            500                 505                 510         


Gly Val Ser His Val Ile Val Asp Glu Val His Glu Arg Asp Val Asn 
        515                 520                 525             


Thr Asp Phe Leu Leu Ile Leu Leu Lys Gly Leu Gln Arg Leu Asn Pro 
    530                 535                 540                 


Ala Leu Arg Leu Val Leu Met Ser Ala Thr Gly Asp Asn Glu Arg Phe 
545                 550                 555                 560 


Ser Arg Tyr Phe Gly Gly Cys Pro Val Ile Lys Val Pro Gly Phe Met 
                565                 570                 575     


Tyr Pro Val Lys Glu His Tyr Leu Glu Asp Ile Leu Ala Lys Leu Gly 
            580                 585                 590         


Lys His Gln Tyr Leu His Arg His Arg His His Glu Ser Glu Asp Glu 
        595                 600                 605             


Cys Ala Leu Asp Leu Asp Leu Val Thr Asp Leu Val Leu His Ile Asp 
    610                 615                 620                 


Ala Arg Gly Glu Pro Gly Gly Ile Leu Cys Phe Leu Pro Gly Trp Gln 
625                 630                 635                 640 


Glu Ile Lys Gly Val Gln Gln Arg Leu Gln Glu Ala Leu Gly Met His 
                645                 650                 655     


Glu Ser Lys Tyr Leu Ile Leu Pro Val His Ser Asn Ile Pro Met Met 
            660                 665                 670         


Asp Gln Lys Ala Ile Phe Gln Gln Pro Pro Val Gly Val Arg Lys Ile 
        675                 680                 685             


Val Leu Ala Thr Asn Ile Ala Glu Thr Ser Ile Thr Ile Asn Asp Ile 
    690                 695                 700                 


Val His Val Val Asp Ser Gly Leu His Lys Glu Glu Arg Tyr Asp Leu 
705                 710                 715                 720 


Lys Thr Lys Val Ser Cys Leu Glu Thr Val Trp Val Ser Arg Ala Asn 
                725                 730                 735     


Val Ile Gln Arg Arg Gly Arg Ala Gly Arg Cys Gln Ser Gly Phe Ala 
            740                 745                 750         


Tyr His Leu Phe Pro Arg Ser Arg Leu Glu Lys Met Val Pro Phe Gln 
        755                 760                 765             


Val Pro Glu Ile Leu Arg Thr Pro Leu Glu Asn Leu Val Leu Gln Ala 
    770                 775                 780                 


Lys Ile His Met Pro Glu Lys Thr Ala Val Glu Phe Leu Ser Lys Ala 
785                 790                 795                 800 


Val Asp Ser Pro Asn Ile Lys Ala Val Asp Glu Ala Val Ile Leu Leu 
                805                 810                 815     


Gln Glu Ile Gly Val Leu Asp Gln Arg Glu Tyr Leu Thr Thr Leu Gly 
            820                 825                 830         


Gln Arg Leu Ala His Ile Ser Thr Asp Pro Arg Leu Ala Lys Ala Ile 
        835                 840                 845             


Val Leu Ala Ala Ile Phe Arg Cys Leu His Pro Leu Leu Val Val Val 
    850                 855                 860                 


Ser Cys Leu Thr Arg Asp Pro Phe Ser Ser Ser Leu Gln Asn Arg Ala 
865                 870                 875                 880 


Glu Val Asp Lys Val Lys Ala Leu Leu Ser His Asp Ser Gly Ser Asp 
                885                 890                 895     


His Leu Ala Phe Val Arg Ala Val Ala Gly Trp Glu Glu Val Leu Arg 
            900                 905                 910         


Trp Gln Asp Arg Ser Ser Arg Glu Asn Tyr Leu Glu Glu Asn Leu Leu 
        915                 920                 925             


Tyr Ala Pro Ser Leu Arg Phe Ile His Gly Leu Ile Lys Gln Phe Ser 
    930                 935                 940                 


Glu Asn Ile Tyr Glu Ala Phe Leu Val Gly Lys Pro Ser Asp Cys Thr 
945                 950                 955                 960 


Leu Ala Ser Ala Gln Cys Asn Glu Tyr Ser Glu Glu Glu Glu Leu Val 
                965                 970                 975     


Lys Gly Val Leu Met Ala Gly Leu Tyr Pro Asn Leu Ile Gln Val Arg 
            980                 985                 990         


Gln Gly Lys Val Thr Arg Gln Gly  Lys Phe Lys Pro Asn  Ser Val Thr 
        995                 1000                 1005             


Tyr Arg  Thr Lys Ser Gly Asn  Ile Leu Leu His Lys  Ser Thr Ile 
    1010                 1015                 1020             


Asn Arg  Glu Ala Thr Arg Leu  Arg Ser Arg Trp Leu  Thr Tyr Phe 
    1025                 1030                 1035             


Met Ala  Val Lys Ser Asn Gly  Ser Val Phe Val Arg  Asp Ser Ser 
    1040                 1045                 1050             


Gln Val  His Pro Leu Ala Val  Leu Leu Leu Thr Asp  Gly Asp Val 
    1055                 1060                 1065             


His Ile  Arg Asp Asp Gly Arg  Arg Ala Thr Ile Ser  Leu Ser Asp 
    1070                 1075                 1080             


Ser Asp  Leu Leu Arg Leu Glu  Gly Asp Ser Arg Thr  Val Arg Leu 
    1085                 1090                 1095             


Leu Lys  Glu Leu Arg Arg Ala  Leu Gly Arg Met Val  Glu Arg Ser 
    1100                 1105                 1110             


Leu Arg  Ser Glu Leu Ala Ala  Leu Pro Pro Ser Val  Gln Glu Glu 
    1115                 1120                 1125             


His Gly  Gln Leu Leu Ala Leu  Leu Ala Glu Leu Leu  Arg Gly Pro 
    1130                 1135                 1140             


Cys Gly  Ser Phe Asp Val Arg  Lys Thr Ala Asp Asp  
    1145                 1150                 1155 


<210>  4223
<211>  1166
<212>  PRT
<213>  Homo Sapiens

<400>  4223

Met Cys Val Asn Pro Thr Pro Gly Gly Thr Ile Ser Arg Ala Ser Arg 
1               5                   10                  15      


Asp Leu Leu Lys Glu Phe Pro Gln Pro Lys Asn Leu Leu Asn Ser Val 
            20                  25                  30          


Ile Gly Arg Ala Leu Gly Ile Ser His Ala Lys Asp Lys Leu Val Tyr 
        35                  40                  45              


Val His Thr Asn Gly Pro Lys Lys Lys Lys Val Thr Leu His Ile Lys 
    50                  55                  60                  


Trp Pro Lys Ser Val Glu Val Glu Gly Tyr Gly Ser Lys Lys Ile Asp 
65                  70                  75                  80  


Ala Glu Arg Gln Ala Ala Ala Ala Ala Cys Gln Leu Phe Lys Gly Trp 
                85                  90                  95      


Gly Leu Leu Gly Pro Arg Asn Glu Leu Phe Asp Ala Ala Lys Tyr Arg 
            100                 105                 110         


Val Leu Ala Asp Arg Phe Gly Ser Pro Ala Asp Ser Trp Trp Arg Pro 
        115                 120                 125             


Glu Pro Thr Met Pro Pro Thr Ser Trp Arg Gln Leu Asn Pro Glu Ser 
    130                 135                 140                 


Ile Arg Pro Gly Gly Pro Gly Gly Leu Ser Arg Ser Leu Gly Arg Glu 
145                 150                 155                 160 


Glu Glu Glu Asp Glu Glu Glu Glu Leu Glu Glu Gly Thr Ile Asp Val 
                165                 170                 175     


Thr Asp Phe Leu Ser Met Thr Gln Gln Asp Ser His Ala Pro Leu Arg 
            180                 185                 190         


Asp Ser Arg Gly Ser Ser Phe Glu Met Thr Asp Asp Asp Ser Ala Ile 
        195                 200                 205             


Arg Ala Leu Thr Gln Phe Pro Leu Pro Lys Asn Leu Leu Ala Lys Val 
    210                 215                 220                 


Ile Gln Ile Ala Thr Ser Ser Ser Thr Ala Lys Asn Leu Met Gln Phe 
225                 230                 235                 240 


His Thr Val Gly Thr Lys Thr Lys Leu Ser Thr Leu Thr Leu Leu Trp 
                245                 250                 255     


Pro Cys Pro Met Thr Phe Val Ala Lys Gly Arg Arg Lys Ala Glu Ala 
            260                 265                 270         


Glu Asn Lys Ala Ala Ala Leu Ala Cys Lys Lys Leu Lys Ser Leu Gly 
        275                 280                 285             


Leu Val Asp Arg Asn Asn Glu Pro Leu Thr His Ala Met Tyr Asn Leu 
    290                 295                 300                 


Ala Ser Leu Arg Glu Leu Gly Glu Thr Gln Arg Arg Pro Cys Thr Ile 
305                 310                 315                 320 


Gln Val Pro Glu Pro Ile Leu Arg Lys Ile Glu Thr Phe Leu Asn His 
                325                 330                 335     


Tyr Pro Val Glu Ser Ser Trp Ile Ala Pro Glu Leu Arg Leu Gln Ser 
            340                 345                 350         


Asp Asp Ile Leu Pro Leu Gly Lys Asp Ser Gly Pro Leu Ser Asp Pro 
        355                 360                 365             


Ile Thr Gly Lys Pro Tyr Val Pro Leu Leu Glu Ala Glu Glu Val Arg 
    370                 375                 380                 


Leu Ser Gln Ser Leu Leu Glu Leu Trp Arg Arg Arg Gly Pro Val Trp 
385                 390                 395                 400 


Gln Glu Ala Pro Gln Leu Pro Val Asp Pro His Arg Asp Thr Ile Leu 
                405                 410                 415     


Asn Ala Ile Glu Gln His Pro Val Val Val Ile Ser Gly Asp Thr Gly 
            420                 425                 430         


Cys Gly Lys Thr Thr Arg Ile Pro Gln Leu Leu Leu Glu Arg Tyr Val 
        435                 440                 445             


Thr Glu Gly Arg Gly Ala Arg Cys Asn Val Ile Ile Thr Gln Pro Arg 
    450                 455                 460                 


Arg Ile Ser Ala Val Ser Val Ala Gln Arg Val Ser His Glu Leu Gly 
465                 470                 475                 480 


Pro Ser Leu Arg Arg Asn Val Gly Phe Gln Val Arg Leu Glu Ser Lys 
                485                 490                 495     


Pro Pro Ser Arg Gly Gly Ala Leu Leu Phe Cys Thr Val Gly Ile Leu 
            500                 505                 510         


Leu Arg Lys Leu Gln Ser Asn Pro Ser Leu Glu Gly Val Ser His Val 
        515                 520                 525             


Ile Val Asp Glu Val His Glu Arg Asp Val Asn Thr Asp Phe Leu Leu 
    530                 535                 540                 


Ile Leu Leu Lys Gly Leu Gln Arg Leu Asn Pro Ala Leu Arg Leu Val 
545                 550                 555                 560 


Leu Met Ser Ala Thr Gly Asp Asn Glu Arg Phe Ser Arg Tyr Phe Gly 
                565                 570                 575     


Gly Cys Pro Val Ile Lys Val Pro Gly Phe Met Tyr Pro Val Lys Glu 
            580                 585                 590         


His Tyr Leu Glu Asp Ile Leu Ala Lys Leu Gly Lys His Gln Tyr Leu 
        595                 600                 605             


His Arg His Arg His His Glu Ser Glu Asp Glu Cys Ala Leu Asp Leu 
    610                 615                 620                 


Asp Leu Val Thr Asp Leu Val Leu His Ile Asp Ala Arg Gly Glu Pro 
625                 630                 635                 640 


Gly Gly Ile Leu Cys Phe Leu Pro Gly Trp Gln Glu Ile Lys Gly Val 
                645                 650                 655     


Gln Gln Arg Leu Gln Glu Ala Leu Gly Met His Glu Ser Lys Tyr Leu 
            660                 665                 670         


Ile Leu Pro Val His Ser Asn Ile Pro Met Met Asp Gln Lys Ala Ile 
        675                 680                 685             


Phe Gln Gln Pro Pro Val Gly Val Arg Lys Ile Val Leu Ala Thr Asn 
    690                 695                 700                 


Ile Ala Glu Thr Ser Ile Thr Ile Asn Asp Ile Val His Val Val Asp 
705                 710                 715                 720 


Ser Gly Leu His Lys Glu Glu Arg Tyr Asp Leu Lys Thr Lys Val Ser 
                725                 730                 735     


Cys Leu Glu Thr Val Trp Val Ser Arg Ala Asn Val Ile Gln Arg Arg 
            740                 745                 750         


Gly Arg Ala Gly Arg Cys Gln Ser Gly Phe Ala Tyr His Leu Phe Pro 
        755                 760                 765             


Arg Ser Arg Leu Glu Lys Met Val Pro Phe Gln Val Pro Glu Ile Leu 
    770                 775                 780                 


Arg Thr Pro Leu Glu Asn Leu Val Leu Gln Ala Lys Ile His Met Pro 
785                 790                 795                 800 


Glu Lys Thr Ala Val Glu Phe Leu Ser Lys Ala Val Asp Ser Pro Asn 
                805                 810                 815     


Ile Lys Ala Val Asp Glu Ala Val Ile Leu Leu Gln Glu Ile Gly Val 
            820                 825                 830         


Leu Asp Gln Arg Glu Tyr Leu Thr Thr Leu Gly Gln Arg Leu Ala His 
        835                 840                 845             


Ile Ser Thr Asp Pro Arg Leu Ala Lys Ala Ile Val Leu Ala Ala Ile 
    850                 855                 860                 


Phe Arg Cys Leu His Pro Leu Leu Val Val Val Ser Cys Leu Thr Arg 
865                 870                 875                 880 


Asp Pro Phe Ser Ser Ser Leu Gln Asn Arg Ala Glu Val Asp Lys Val 
                885                 890                 895     


Lys Ala Leu Leu Ser His Asp Ser Gly Ser Asp His Leu Ala Phe Val 
            900                 905                 910         


Arg Ala Val Ala Gly Trp Glu Glu Val Leu Arg Trp Gln Asp Arg Ser 
        915                 920                 925             


Ser Arg Glu Asn Tyr Leu Glu Glu Asn Leu Leu Tyr Ala Pro Ser Leu 
    930                 935                 940                 


Arg Phe Ile His Gly Leu Ile Lys Gln Phe Ser Glu Asn Ile Tyr Glu 
945                 950                 955                 960 


Ala Phe Leu Val Gly Lys Pro Ser Asp Cys Thr Leu Ala Ser Ala Gln 
                965                 970                 975     


Cys Asn Glu Tyr Ser Glu Glu Glu Glu Leu Val Lys Gly Val Leu Met 
            980                 985                 990         


Ala Gly Leu Tyr Pro Asn Leu Ile  Gln Val Arg Gln Gly  Lys Val Thr 
        995                 1000                 1005             


Arg Gln  Gly Lys Phe Lys Pro  Asn Ser Val Thr Tyr  Arg Thr Lys 
    1010                 1015                 1020             


Ser Gly  Asn Ile Leu Leu His  Lys Ser Thr Ile Asn  Arg Glu Ala 
    1025                 1030                 1035             


Thr Arg  Leu Arg Ser Arg Trp  Leu Thr Tyr Phe Met  Ala Val Lys 
    1040                 1045                 1050             


Ser Asn  Gly Ser Val Phe Val  Arg Asp Ser Ser Gln  Val His Pro 
    1055                 1060                 1065             


Leu Ala  Val Leu Leu Leu Thr  Asp Gly Asp Val His  Ile Arg Asp 
    1070                 1075                 1080             


Asp Gly  Arg Arg Ala Thr Ile  Ser Leu Ser Asp Ser  Asp Leu Leu 
    1085                 1090                 1095             


Arg Leu  Glu Gly Asp Ser Arg  Thr Val Arg Leu Leu  Lys Glu Leu 
    1100                 1105                 1110             


Arg Arg  Ala Leu Gly Arg Met  Val Glu Arg Ser Leu  Arg Ser Glu 
    1115                 1120                 1125             


Leu Ala  Ala Leu Pro Pro Ser  Val Gln Glu Glu His  Gly Gln Leu 
    1130                 1135                 1140             


Leu Ala  Leu Leu Ala Glu Leu  Leu Arg Gly Pro Cys  Gly Ser Phe 
    1145                 1150                 1155             


Asp Val  Arg Lys Thr Ala Asp  Asp 
    1160                 1165     


<210>  4224
<211>  1194
<212>  PRT
<213>  Homo Sapiens

<400>  4224

Met Phe Ser Leu Asp Ser Phe Arg Lys Asp Arg Ala Gln His Arg Gln 
1               5                   10                  15      


Arg Gln Cys Lys Leu Pro Pro Pro Arg Leu Pro Pro Met Cys Val Asn 
            20                  25                  30          


Pro Thr Pro Gly Gly Thr Ile Ser Arg Ala Ser Arg Asp Leu Leu Lys 
        35                  40                  45              


Glu Phe Pro Gln Pro Lys Asn Leu Leu Asn Ser Val Ile Gly Arg Ala 
    50                  55                  60                  


Leu Gly Ile Ser His Ala Lys Asp Lys Leu Val Tyr Val His Thr Asn 
65                  70                  75                  80  


Gly Pro Lys Lys Lys Lys Val Thr Leu His Ile Lys Trp Pro Lys Ser 
                85                  90                  95      


Val Glu Val Glu Gly Tyr Gly Ser Lys Lys Ile Asp Ala Glu Arg Gln 
            100                 105                 110         


Ala Ala Ala Ala Ala Cys Gln Leu Phe Lys Gly Trp Gly Leu Leu Gly 
        115                 120                 125             


Pro Arg Asn Glu Leu Phe Asp Ala Ala Lys Tyr Arg Val Leu Ala Asp 
    130                 135                 140                 


Arg Phe Gly Ser Pro Ala Asp Ser Trp Trp Arg Pro Glu Pro Thr Met 
145                 150                 155                 160 


Pro Pro Thr Ser Trp Arg Gln Leu Asn Pro Glu Ser Ile Arg Pro Gly 
                165                 170                 175     


Gly Pro Gly Gly Leu Ser Arg Ser Leu Gly Arg Glu Glu Glu Glu Asp 
            180                 185                 190         


Glu Glu Glu Glu Leu Glu Glu Gly Thr Ile Asp Val Thr Asp Phe Leu 
        195                 200                 205             


Ser Met Thr Gln Gln Asp Ser His Ala Pro Leu Arg Asp Ser Arg Gly 
    210                 215                 220                 


Ser Ser Phe Glu Met Thr Asp Asp Asp Ser Ala Ile Arg Ala Leu Thr 
225                 230                 235                 240 


Gln Phe Pro Leu Pro Lys Asn Leu Leu Ala Lys Val Ile Gln Ile Ala 
                245                 250                 255     


Thr Ser Ser Ser Thr Ala Lys Asn Leu Met Gln Phe His Thr Val Gly 
            260                 265                 270         


Thr Lys Thr Lys Leu Ser Thr Leu Thr Leu Leu Trp Pro Cys Pro Met 
        275                 280                 285             


Thr Phe Val Ala Lys Gly Arg Arg Lys Ala Glu Ala Glu Asn Lys Ala 
    290                 295                 300                 


Ala Ala Leu Ala Cys Lys Lys Leu Lys Ser Leu Gly Leu Val Asp Arg 
305                 310                 315                 320 


Asn Asn Glu Pro Leu Thr His Ala Met Tyr Asn Leu Ala Ser Leu Arg 
                325                 330                 335     


Glu Leu Gly Glu Thr Gln Arg Arg Pro Cys Thr Ile Gln Val Pro Glu 
            340                 345                 350         


Pro Ile Leu Arg Lys Ile Glu Thr Phe Leu Asn His Tyr Pro Val Glu 
        355                 360                 365             


Ser Ser Trp Ile Ala Pro Glu Leu Arg Leu Gln Ser Asp Asp Ile Leu 
    370                 375                 380                 


Pro Leu Gly Lys Asp Ser Gly Pro Leu Ser Asp Pro Ile Thr Gly Lys 
385                 390                 395                 400 


Pro Tyr Val Pro Leu Leu Glu Ala Glu Glu Val Arg Leu Ser Gln Ser 
                405                 410                 415     


Leu Leu Glu Leu Trp Arg Arg Arg Gly Pro Val Trp Gln Glu Ala Pro 
            420                 425                 430         


Gln Leu Pro Val Asp Pro His Arg Asp Thr Ile Leu Asn Ala Ile Glu 
        435                 440                 445             


Gln His Pro Val Val Val Ile Ser Gly Asp Thr Gly Cys Gly Lys Thr 
    450                 455                 460                 


Thr Arg Ile Pro Gln Leu Leu Leu Glu Arg Tyr Val Thr Glu Gly Arg 
465                 470                 475                 480 


Gly Ala Arg Cys Asn Val Ile Ile Thr Gln Pro Arg Arg Ile Ser Ala 
                485                 490                 495     


Val Ser Val Ala Gln Arg Val Ser His Glu Leu Gly Pro Ser Leu Arg 
            500                 505                 510         


Arg Asn Val Gly Phe Gln Val Arg Leu Glu Ser Lys Pro Pro Ser Arg 
        515                 520                 525             


Gly Gly Ala Leu Leu Phe Cys Thr Val Gly Ile Leu Leu Arg Lys Leu 
    530                 535                 540                 


Gln Ser Asn Pro Ser Leu Glu Gly Val Ser His Val Ile Val Asp Glu 
545                 550                 555                 560 


Val His Glu Arg Asp Val Asn Thr Asp Phe Leu Leu Ile Leu Leu Lys 
                565                 570                 575     


Gly Leu Gln Arg Leu Asn Pro Ala Leu Arg Leu Val Leu Met Ser Ala 
            580                 585                 590         


Thr Gly Asp Asn Glu Arg Phe Ser Arg Tyr Phe Gly Gly Cys Pro Val 
        595                 600                 605             


Ile Lys Val Pro Gly Phe Met Tyr Pro Val Lys Glu His Tyr Leu Glu 
    610                 615                 620                 


Asp Ile Leu Ala Lys Leu Gly Lys His Gln Tyr Leu His Arg His Arg 
625                 630                 635                 640 


His His Glu Ser Glu Asp Glu Cys Ala Leu Asp Leu Asp Leu Val Thr 
                645                 650                 655     


Asp Leu Val Leu His Ile Asp Ala Arg Gly Glu Pro Gly Gly Ile Leu 
            660                 665                 670         


Cys Phe Leu Pro Gly Trp Gln Glu Ile Lys Gly Val Gln Gln Arg Leu 
        675                 680                 685             


Gln Glu Ala Leu Gly Met His Glu Ser Lys Tyr Leu Ile Leu Pro Val 
    690                 695                 700                 


His Ser Asn Ile Pro Met Met Asp Gln Lys Ala Ile Phe Gln Gln Pro 
705                 710                 715                 720 


Pro Val Gly Val Arg Lys Ile Val Leu Ala Thr Asn Ile Ala Glu Thr 
                725                 730                 735     


Ser Ile Thr Ile Asn Asp Ile Val His Val Val Asp Ser Gly Leu His 
            740                 745                 750         


Lys Glu Glu Arg Tyr Asp Leu Lys Thr Lys Val Ser Cys Leu Glu Thr 
        755                 760                 765             


Val Trp Val Ser Arg Ala Asn Val Ile Gln Arg Arg Gly Arg Ala Gly 
    770                 775                 780                 


Arg Cys Gln Ser Gly Phe Ala Tyr His Leu Phe Pro Arg Ser Arg Leu 
785                 790                 795                 800 


Glu Lys Met Val Pro Phe Gln Val Pro Glu Ile Leu Arg Thr Pro Leu 
                805                 810                 815     


Glu Asn Leu Val Leu Gln Ala Lys Ile His Met Pro Glu Lys Thr Ala 
            820                 825                 830         


Val Glu Phe Leu Ser Lys Ala Val Asp Ser Pro Asn Ile Lys Ala Val 
        835                 840                 845             


Asp Glu Ala Val Ile Leu Leu Gln Glu Ile Gly Val Leu Asp Gln Arg 
    850                 855                 860                 


Glu Tyr Leu Thr Thr Leu Gly Gln Arg Leu Ala His Ile Ser Thr Asp 
865                 870                 875                 880 


Pro Arg Leu Ala Lys Ala Ile Val Leu Ala Ala Ile Phe Arg Cys Leu 
                885                 890                 895     


His Pro Leu Leu Val Val Val Ser Cys Leu Thr Arg Asp Pro Phe Ser 
            900                 905                 910         


Ser Ser Leu Gln Asn Arg Ala Glu Val Asp Lys Val Lys Ala Leu Leu 
        915                 920                 925             


Ser His Asp Ser Gly Ser Asp His Leu Ala Phe Val Arg Ala Val Ala 
    930                 935                 940                 


Gly Trp Glu Glu Val Leu Arg Trp Gln Asp Arg Ser Ser Arg Glu Asn 
945                 950                 955                 960 


Tyr Leu Glu Glu Asn Leu Leu Tyr Ala Pro Ser Leu Arg Phe Ile His 
                965                 970                 975     


Gly Leu Ile Lys Gln Phe Ser Glu Asn Ile Tyr Glu Ala Phe Leu Val 
            980                 985                 990         


Gly Lys Pro Ser Asp Cys Thr Leu  Ala Ser Ala Gln Cys  Asn Glu Tyr 
        995                 1000                 1005             


Ser Glu  Glu Glu Glu Leu Val  Lys Gly Val Leu Met  Ala Gly Leu 
    1010                 1015                 1020             


Tyr Pro  Asn Leu Ile Gln Val  Arg Gln Gly Lys Val  Thr Arg Gln 
    1025                 1030                 1035             


Gly Lys  Phe Lys Pro Asn Ser  Val Thr Tyr Arg Thr  Lys Ser Gly 
    1040                 1045                 1050             


Asn Ile  Leu Leu His Lys Ser  Thr Ile Asn Arg Glu  Ala Thr Arg 
    1055                 1060                 1065             


Leu Arg  Ser Arg Trp Leu Thr  Tyr Phe Met Ala Val  Lys Ser Asn 
    1070                 1075                 1080             


Gly Ser  Val Phe Val Arg Asp  Ser Ser Gln Val His  Pro Leu Ala 
    1085                 1090                 1095             


Val Leu  Leu Leu Thr Asp Gly  Asp Val His Ile Arg  Asp Asp Gly 
    1100                 1105                 1110             


Arg Arg  Ala Thr Ile Ser Leu  Ser Asp Ser Asp Leu  Leu Arg Leu 
    1115                 1120                 1125             


Glu Gly  Asp Ser Arg Thr Val  Arg Leu Leu Lys Glu  Leu Arg Arg 
    1130                 1135                 1140             


Ala Leu  Gly Arg Met Val Glu  Arg Ser Leu Arg Ser  Glu Leu Ala 
    1145                 1150                 1155             


Ala Leu  Pro Pro Ser Val Gln  Glu Glu His Gly Gln  Leu Leu Ala 
    1160                 1165                 1170             


Leu Leu  Ala Glu Leu Leu Arg  Gly Pro Cys Gly Ser  Phe Asp Val 
    1175                 1180                 1185             


Arg Lys  Thr Ala Asp Asp 
    1190                 


<210>  4225
<211>  1194
<212>  PRT
<213>  Homo Sapiens

<400>  4225

Met Phe Ser Leu Asp Ser Phe Arg Lys Asp Arg Ala Gln His Arg Gln 
1               5                   10                  15      


Arg Gln Cys Lys Leu Pro Pro Pro Arg Leu Pro Pro Met Cys Val Asn 
            20                  25                  30          


Pro Thr Pro Gly Gly Thr Ile Ser Arg Ala Ser Arg Asp Leu Leu Lys 
        35                  40                  45              


Glu Phe Pro Gln Pro Lys Asn Leu Leu Asn Ser Val Ile Gly Arg Ala 
    50                  55                  60                  


Leu Gly Ile Ser His Ala Lys Asp Lys Leu Val Tyr Val His Thr Asn 
65                  70                  75                  80  


Gly Pro Lys Lys Lys Lys Val Thr Leu His Ile Lys Trp Pro Lys Ser 
                85                  90                  95      


Val Glu Val Glu Gly Tyr Gly Ser Lys Lys Ile Asp Ala Glu Arg Gln 
            100                 105                 110         


Ala Ala Ala Ala Ala Cys Gln Leu Phe Lys Gly Trp Gly Leu Leu Gly 
        115                 120                 125             


Pro Arg Asn Glu Leu Phe Asp Ala Ala Lys Tyr Arg Val Leu Ala Asp 
    130                 135                 140                 


Arg Phe Gly Ser Pro Ala Asp Ser Trp Trp Arg Pro Glu Pro Thr Met 
145                 150                 155                 160 


Pro Pro Thr Ser Trp Arg Gln Leu Asn Pro Glu Ser Ile Arg Pro Gly 
                165                 170                 175     


Gly Pro Gly Gly Leu Ser Arg Ser Leu Gly Arg Glu Glu Glu Glu Asp 
            180                 185                 190         


Glu Glu Glu Glu Leu Glu Glu Gly Thr Ile Asp Val Thr Asp Phe Leu 
        195                 200                 205             


Ser Met Thr Gln Gln Asp Ser His Ala Pro Leu Arg Asp Ser Arg Gly 
    210                 215                 220                 


Ser Ser Phe Glu Met Thr Asp Asp Asp Ser Ala Ile Arg Ala Leu Thr 
225                 230                 235                 240 


Gln Phe Pro Leu Pro Lys Asn Leu Leu Ala Lys Val Ile Gln Ile Ala 
                245                 250                 255     


Thr Ser Ser Ser Thr Ala Lys Asn Leu Met Gln Phe His Thr Val Gly 
            260                 265                 270         


Thr Lys Thr Lys Leu Ser Thr Leu Thr Leu Leu Trp Pro Cys Pro Met 
        275                 280                 285             


Thr Phe Val Ala Lys Gly Arg Arg Lys Ala Glu Ala Glu Asn Lys Ala 
    290                 295                 300                 


Ala Ala Leu Ala Cys Lys Lys Leu Lys Ser Leu Gly Leu Val Asp Arg 
305                 310                 315                 320 


Asn Asn Glu Pro Leu Thr His Ala Met Tyr Asn Leu Ala Ser Leu Arg 
                325                 330                 335     


Glu Leu Gly Glu Thr Gln Arg Arg Pro Cys Thr Ile Gln Val Pro Glu 
            340                 345                 350         


Pro Ile Leu Arg Lys Ile Glu Thr Phe Leu Asn His Tyr Pro Val Glu 
        355                 360                 365             


Ser Ser Trp Ile Ala Pro Glu Leu Arg Leu Gln Ser Asp Asp Ile Leu 
    370                 375                 380                 


Pro Leu Gly Lys Asp Ser Gly Pro Leu Ser Asp Pro Ile Thr Gly Lys 
385                 390                 395                 400 


Pro Tyr Val Pro Leu Leu Glu Ala Glu Glu Val Arg Leu Ser Gln Ser 
                405                 410                 415     


Leu Leu Glu Leu Trp Arg Arg Arg Gly Pro Val Trp Gln Glu Ala Pro 
            420                 425                 430         


Gln Leu Pro Val Asp Pro His Arg Asp Thr Ile Leu Asn Ala Ile Glu 
        435                 440                 445             


Gln His Pro Val Val Val Ile Ser Gly Asp Thr Gly Cys Gly Lys Thr 
    450                 455                 460                 


Thr Arg Ile Pro Gln Leu Leu Leu Glu Arg Tyr Val Thr Glu Gly Arg 
465                 470                 475                 480 


Gly Ala Arg Cys Asn Val Ile Ile Thr Gln Pro Arg Arg Ile Ser Ala 
                485                 490                 495     


Val Ser Val Ala Gln Arg Val Ser His Glu Leu Gly Pro Ser Leu Arg 
            500                 505                 510         


Arg Asn Val Gly Phe Gln Val Arg Leu Glu Ser Lys Pro Pro Ser Arg 
        515                 520                 525             


Gly Gly Ala Leu Leu Phe Cys Thr Val Gly Ile Leu Leu Arg Lys Leu 
    530                 535                 540                 


Gln Ser Asn Pro Ser Leu Glu Gly Val Ser His Val Ile Val Asp Glu 
545                 550                 555                 560 


Val His Glu Arg Asp Val Asn Thr Asp Phe Leu Leu Ile Leu Leu Lys 
                565                 570                 575     


Gly Leu Gln Arg Leu Asn Pro Ala Leu Arg Leu Val Leu Met Ser Ala 
            580                 585                 590         


Thr Gly Asp Asn Glu Arg Phe Ser Arg Tyr Phe Gly Gly Cys Pro Val 
        595                 600                 605             


Ile Lys Val Pro Gly Phe Met Tyr Pro Val Lys Glu His Tyr Leu Glu 
    610                 615                 620                 


Asp Ile Leu Ala Lys Leu Gly Lys His Gln Tyr Leu His Arg His Arg 
625                 630                 635                 640 


His His Glu Ser Glu Asp Glu Cys Ala Leu Asp Leu Asp Leu Val Thr 
                645                 650                 655     


Asp Leu Val Leu His Ile Asp Ala Arg Gly Glu Pro Gly Gly Ile Leu 
            660                 665                 670         


Cys Phe Leu Pro Gly Trp Gln Glu Ile Lys Gly Val Gln Gln Arg Leu 
        675                 680                 685             


Gln Glu Ala Leu Gly Met His Glu Ser Lys Tyr Leu Ile Leu Pro Val 
    690                 695                 700                 


His Ser Asn Ile Pro Met Met Asp Gln Lys Ala Ile Phe Gln Gln Pro 
705                 710                 715                 720 


Pro Val Gly Val Arg Lys Ile Val Leu Ala Thr Asn Ile Ala Glu Thr 
                725                 730                 735     


Ser Ile Thr Ile Asn Asp Ile Val His Val Val Asp Ser Gly Leu His 
            740                 745                 750         


Lys Glu Glu Arg Tyr Asp Leu Lys Thr Lys Val Ser Cys Leu Glu Thr 
        755                 760                 765             


Val Trp Val Ser Arg Ala Asn Val Ile Gln Arg Arg Gly Arg Ala Gly 
    770                 775                 780                 


Arg Cys Gln Ser Gly Phe Ala Tyr His Leu Phe Pro Arg Ser Arg Leu 
785                 790                 795                 800 


Glu Lys Met Val Pro Phe Gln Val Pro Glu Ile Leu Arg Thr Pro Leu 
                805                 810                 815     


Glu Asn Leu Val Leu Gln Ala Lys Ile His Met Pro Glu Lys Thr Ala 
            820                 825                 830         


Val Glu Phe Leu Ser Lys Ala Val Asp Ser Pro Asn Ile Lys Ala Val 
        835                 840                 845             


Asp Glu Ala Val Ile Leu Leu Gln Glu Ile Gly Val Leu Asp Gln Arg 
    850                 855                 860                 


Glu Tyr Leu Thr Thr Leu Gly Gln Arg Leu Ala His Ile Ser Thr Asp 
865                 870                 875                 880 


Pro Arg Leu Ala Lys Ala Ile Val Leu Ala Ala Ile Phe Arg Cys Leu 
                885                 890                 895     


His Pro Leu Leu Val Val Val Ser Cys Leu Thr Arg Asp Pro Phe Ser 
            900                 905                 910         


Ser Ser Leu Gln Asn Arg Ala Glu Val Asp Lys Val Lys Ala Leu Leu 
        915                 920                 925             


Ser His Asp Ser Gly Ser Asp His Leu Ala Phe Val Arg Ala Val Ala 
    930                 935                 940                 


Gly Trp Glu Glu Val Leu Arg Trp Gln Asp Arg Ser Ser Arg Glu Asn 
945                 950                 955                 960 


Tyr Leu Glu Glu Asn Leu Leu Tyr Ala Pro Ser Leu Arg Phe Ile His 
                965                 970                 975     


Gly Leu Ile Lys Gln Phe Ser Glu Asn Ile Tyr Glu Ala Phe Leu Val 
            980                 985                 990         


Gly Lys Pro Ser Asp Cys Thr Leu  Ala Ser Ala Gln Cys  Asn Glu Tyr 
        995                 1000                 1005             


Ser Glu  Glu Glu Glu Leu Val  Lys Gly Val Leu Met  Ala Gly Leu 
    1010                 1015                 1020             


Tyr Pro  Asn Leu Ile Gln Val  Arg Gln Gly Lys Val  Thr Arg Gln 
    1025                 1030                 1035             


Gly Lys  Phe Lys Pro Asn Ser  Val Thr Tyr Arg Thr  Lys Ser Gly 
    1040                 1045                 1050             


Asn Ile  Leu Leu His Lys Ser  Thr Ile Asn Arg Glu  Ala Thr Arg 
    1055                 1060                 1065             


Leu Arg  Ser Arg Trp Leu Thr  Tyr Phe Met Ala Val  Lys Ser Asn 
    1070                 1075                 1080             


Gly Ser  Val Phe Val Arg Asp  Ser Ser Gln Val His  Pro Leu Ala 
    1085                 1090                 1095             


Val Leu  Leu Leu Thr Asp Gly  Asp Val His Ile Arg  Asp Asp Gly 
    1100                 1105                 1110             


Arg Arg  Ala Thr Ile Ser Leu  Ser Asp Ser Asp Leu  Leu Arg Leu 
    1115                 1120                 1125             


Glu Gly  Asp Ser Arg Thr Val  Arg Leu Leu Lys Glu  Leu Arg Arg 
    1130                 1135                 1140             


Ala Leu  Gly Arg Met Val Glu  Arg Ser Leu Arg Ser  Glu Leu Ala 
    1145                 1150                 1155             


Ala Leu  Pro Pro Ser Val Gln  Glu Glu His Gly Gln  Leu Leu Ala 
    1160                 1165                 1170             


Leu Leu  Ala Glu Leu Leu Arg  Gly Pro Cys Gly Ser  Phe Asp Val 
    1175                 1180                 1185             


Arg Lys  Thr Ala Asp Asp 
    1190                 


<210>  4226
<211>  42
<212>  PRT
<213>  Homo Sapiens

<400>  4226

Met Phe Ser Leu Asp Ser Phe Arg Lys Asp Arg Ala Gln His Arg Gln 
1               5                   10                  15      


Arg Gln Cys Lys Leu Pro Pro Pro Arg Leu Pro Pro Met Cys Val Asn 
            20                  25                  30          


Pro Thr Pro Gly Gly Thr Ile Ser Arg Gly 
        35                  40          


<210>  4227
<211>  42
<212>  PRT
<213>  Homo Sapiens

<400>  4227

Met Phe Ser Leu Asp Ser Phe Arg Lys Asp Arg Ala Gln His Arg Gln 
1               5                   10                  15      


Arg Gln Cys Lys Leu Pro Pro Pro Arg Leu Pro Pro Met Cys Val Asn 
            20                  25                  30          


Pro Thr Pro Gly Gly Thr Ile Ser Arg Gly 
        35                  40          


<210>  4228
<211>  42
<212>  PRT
<213>  Homo Sapiens

<400>  4228

Met Phe Ser Leu Asp Ser Phe Arg Lys Asp Arg Ala Gln His Arg Gln 
1               5                   10                  15      


Arg Gln Cys Lys Leu Pro Pro Pro Arg Leu Pro Pro Met Cys Val Asn 
            20                  25                  30          


Pro Thr Pro Gly Gly Thr Ile Ser Arg Gly 
        35                  40          


<210>  4229
<211>  138
<212>  PRT
<213>  Homo Sapiens

<400>  4229

Lys Ala Lys Phe His Gln Thr Glu Gly Asp His Leu Thr Leu Leu Ala 
1               5                   10                  15      


Val Tyr Asn Ser Trp Lys Asn Asn Lys Phe Ser Asn Pro Trp Cys Tyr 
            20                  25                  30          


Glu Asn Phe Ile Gln Ala Arg Ser Leu Arg Arg Ala Gln Asp Ile Arg 
        35                  40                  45              


Lys Gln Met Leu Gly Ile Met Asp Arg His Lys Leu Asp Val Val Ser 
    50                  55                  60                  


Cys Gly Lys Ser Thr Val Arg Val Gln Lys Ala Ile Cys Ser Gly Phe 
65                  70                  75                  80  


Phe Arg Asn Ala Ala Lys Lys Asp Pro Gln Glu Gly Tyr Arg Thr Leu 
                85                  90                  95      


Ile Asp Gln Gln Val Val Tyr Ile His Pro Ser Ser Ala Leu Phe Asn 
            100                 105                 110         


Arg Gln Pro Glu Trp Asp Leu Tyr Ser Arg Phe Ser Glu Trp Lys Ser 
        115                 120                 125             


Gly Thr Asn Cys Ser Ser Leu Ser Gly Thr 
    130                 135             


<210>  4230
<211>  1220
<212>  PRT
<213>  Homo Sapiens

<400>  4230

Met Ala Val Ala Val Ala Met Ala Gly Ala Leu Ile Gly Ser Glu Pro 
1               5                   10                  15      


Gly Pro Ala Glu Glu Leu Ala Lys Leu Glu Tyr Leu Ser Leu Val Ser 
            20                  25                  30          


Lys Val Cys Thr Glu Leu Asp Asn His Leu Gly Ile Asn Asp Lys Asp 
        35                  40                  45              


Leu Ala Glu Phe Val Ile Ser Leu Ala Glu Lys Asn Thr Thr Phe Asp 
    50                  55                  60                  


Thr Phe Lys Ala Ser Leu Val Lys Asn Gly Ala Glu Phe Thr Asp Ser 
65                  70                  75                  80  


Leu Ile Ser Asn Leu Leu Arg Leu Ile Gln Thr Met Arg Pro Pro Ala 
                85                  90                  95      


Lys Pro Ser Thr Ser Lys Asp Pro Val Val Lys Pro Lys Thr Glu Lys 
            100                 105                 110         


Glu Lys Leu Lys Glu Leu Phe Pro Val Leu Cys Gln Pro Asp Asn Pro 
        115                 120                 125             


Ser Val Arg Thr Met Leu Asp Glu Asp Asp Val Lys Val Ala Val Asp 
    130                 135                 140                 


Val Leu Lys Glu Leu Glu Ala Leu Met Pro Ser Ala Ala Gly Gln Glu 
145                 150                 155                 160 


Lys Gln Arg Asp Ala Glu His Arg Asp Arg Thr Lys Lys Lys Lys Arg 
                165                 170                 175     


Ser Arg Ser Arg Asp Arg Asn Arg Asp Arg Asp Arg Asp Arg Glu Arg 
            180                 185                 190         


Asn Arg Asp Arg Asp His Lys Arg Arg His Arg Ser Arg Ser Arg Ser 
        195                 200                 205             


Arg Ser Arg Thr Arg Glu Arg Asn Lys Val Lys Ser Arg Tyr Arg Ser 
    210                 215                 220                 


Arg Ser Arg Ser Gln Ser Pro Pro Lys Asp Arg Lys Asp Arg Asp Lys 
225                 230                 235                 240 


Tyr Gly Glu Arg Asn Leu Asp Arg Trp Arg Asp Lys His Val Asp Arg 
                245                 250                 255     


Pro Pro Pro Glu Glu Pro Thr Ile Gly Asp Ile Tyr Asn Gly Lys Val 
            260                 265                 270         


Thr Ser Ile Met Gln Phe Gly Cys Phe Val Gln Leu Glu Gly Leu Arg 
        275                 280                 285             


Lys Arg Trp Glu Gly Leu Val His Ile Ser Glu Leu Arg Arg Glu Gly 
    290                 295                 300                 


Arg Val Ala Asn Val Ala Asp Val Val Ser Lys Gly Gln Arg Val Lys 
305                 310                 315                 320 


Val Lys Val Leu Ser Phe Thr Gly Thr Lys Thr Ser Leu Ser Met Lys 
                325                 330                 335     


Asp Val Asp Gln Glu Thr Gly Glu Asp Leu Asn Pro Asn Arg Arg Arg 
            340                 345                 350         


Asn Leu Val Gly Glu Thr Asn Glu Glu Thr Ser Met Arg Asn Pro Asp 
        355                 360                 365             


Arg Pro Thr His Leu Ser Leu Val Ser Ala Pro Glu Val Glu Asp Asp 
    370                 375                 380                 


Ser Leu Glu Arg Lys Arg Leu Thr Arg Ile Ser Asp Pro Glu Lys Trp 
385                 390                 395                 400 


Glu Ile Lys Gln Met Ile Ala Ala Asn Val Leu Ser Lys Glu Glu Phe 
                405                 410                 415     


Pro Asp Phe Asp Glu Glu Thr Gly Ile Leu Pro Lys Val Asp Asp Glu 
            420                 425                 430         


Glu Asp Glu Asp Leu Glu Ile Glu Leu Val Glu Glu Glu Pro Pro Phe 
        435                 440                 445             


Leu Arg Gly His Thr Lys Gln Ser Met Asp Met Ser Pro Ile Lys Ile 
    450                 455                 460                 


Val Lys Asn Pro Asp Gly Ser Leu Ser Gln Ala Ala Met Met Gln Ser 
465                 470                 475                 480 


Ala Leu Ala Lys Glu Arg Arg Glu Leu Lys Gln Ala Gln Arg Glu Ala 
                485                 490                 495     


Glu Met Asp Ser Ile Pro Met Gly Leu Asn Lys His Trp Val Asp Pro 
            500                 505                 510         


Leu Pro Asp Ala Glu Gly Arg Gln Ile Ala Ala Asn Met Arg Gly Ile 
        515                 520                 525             


Gly Met Met Pro Asn Asp Ile Pro Glu Trp Lys Lys His Ala Phe Gly 
    530                 535                 540                 


Gly Asn Lys Ala Ser Tyr Gly Lys Lys Thr Gln Met Ser Ile Leu Glu 
545                 550                 555                 560 


Gln Arg Glu Ser Leu Pro Ile Tyr Lys Leu Lys Glu Gln Leu Val Gln 
                565                 570                 575     


Ala Val His Asp Asn Gln Ile Leu Ile Val Ile Gly Glu Thr Gly Ser 
            580                 585                 590         


Gly Lys Thr Thr Gln Ile Thr Gln Tyr Leu Ala Glu Ala Gly Tyr Thr 
        595                 600                 605             


Ser Arg Gly Lys Ile Gly Cys Thr Gln Pro Arg Arg Val Ala Ala Met 
    610                 615                 620                 


Ser Val Ala Lys Arg Val Ser Glu Glu Phe Gly Cys Cys Leu Gly Gln 
625                 630                 635                 640 


Glu Val Gly Tyr Thr Ile Arg Phe Glu Asp Cys Thr Ser Pro Glu Thr 
                645                 650                 655     


Val Ile Lys Tyr Met Thr Asp Gly Met Leu Leu Arg Glu Cys Leu Ile 
            660                 665                 670         


Asp Pro Asp Leu Thr Gln Tyr Ala Ile Ile Met Leu Asp Glu Ala His 
        675                 680                 685             


Glu Arg Thr Ile His Thr Asp Val Leu Phe Gly Leu Leu Lys Lys Thr 
    690                 695                 700                 


Val Gln Lys Arg Gln Asp Met Lys Leu Ile Val Thr Ser Ala Thr Leu 
705                 710                 715                 720 


Asp Ala Val Lys Phe Ser Gln Tyr Phe Tyr Glu Ala Pro Ile Phe Thr 
                725                 730                 735     


Ile Pro Gly Arg Thr Tyr Pro Val Glu Ile Leu Tyr Thr Lys Glu Pro 
            740                 745                 750         


Glu Thr Asp Tyr Leu Asp Ala Ser Leu Ile Thr Val Met Gln Ile His 
        755                 760                 765             


Leu Thr Glu Pro Pro Gly Asp Ile Leu Val Phe Leu Thr Gly Gln Glu 
    770                 775                 780                 


Glu Ile Asp Thr Ala Cys Glu Ile Leu Tyr Glu Arg Met Lys Ser Leu 
785                 790                 795                 800 


Gly Pro Asp Val Pro Glu Leu Ile Ile Leu Pro Val Tyr Ser Ala Leu 
                805                 810                 815     


Pro Ser Glu Met Gln Thr Arg Ile Phe Asp Pro Ala Pro Pro Gly Ser 
            820                 825                 830         


Arg Lys Val Val Ile Ala Thr Asn Ile Ala Glu Thr Ser Leu Thr Ile 
        835                 840                 845             


Asp Gly Ile Tyr Tyr Val Val Asp Pro Gly Phe Val Lys Gln Lys Val 
    850                 855                 860                 


Tyr Asn Ser Lys Thr Gly Ile Asp Gln Leu Val Val Thr Pro Ile Ser 
865                 870                 875                 880 


Gln Ala Gln Ala Lys Gln Arg Ala Gly Arg Ala Gly Arg Thr Gly Pro 
                885                 890                 895     


Gly Lys Cys Tyr Arg Leu Tyr Thr Glu Arg Ala Tyr Arg Asp Glu Met 
            900                 905                 910         


Leu Thr Thr Asn Val Pro Glu Ile Gln Arg Thr Asn Leu Ala Ser Thr 
        915                 920                 925             


Val Leu Ser Leu Lys Ala Met Gly Ile Asn Asp Leu Leu Ser Phe Asp 
    930                 935                 940                 


Phe Met Asp Ala Pro Pro Met Glu Thr Leu Ile Thr Ala Met Glu Gln 
945                 950                 955                 960 


Leu Tyr Thr Leu Gly Ala Leu Asp Asp Glu Gly Leu Leu Thr Arg Leu 
                965                 970                 975     


Gly Arg Arg Met Ala Glu Phe Pro Leu Glu Pro Met Leu Cys Lys Met 
            980                 985                 990         


Leu Ile Met Ser Val His Leu Gly  Cys Ser Glu Glu Met  Leu Thr Ile 
        995                 1000                 1005             


Val Ser  Met Leu Ser Val Gln  Asn Val Phe Tyr Arg  Pro Lys Asp 
    1010                 1015                 1020             


Lys Gln  Ala Leu Ala Asp Gln  Lys Lys Ala Lys Phe  His Gln Thr 
    1025                 1030                 1035             


Glu Gly  Asp His Leu Thr Leu  Leu Ala Val Tyr Asn  Ser Trp Lys 
    1040                 1045                 1050             


Asn Asn  Lys Phe Ser Asn Pro  Trp Cys Tyr Glu Asn  Phe Ile Gln 
    1055                 1060                 1065             


Ala Arg  Ser Leu Arg Arg Ala  Gln Asp Ile Arg Lys  Gln Met Leu 
    1070                 1075                 1080             


Gly Ile  Met Asp Arg His Lys  Leu Asp Val Val Ser  Cys Gly Lys 
    1085                 1090                 1095             


Ser Thr  Val Arg Val Gln Lys  Ala Ile Cys Ser Gly  Phe Phe Arg 
    1100                 1105                 1110             


Asn Ala  Ala Lys Lys Asp Pro  Gln Glu Gly Tyr Arg  Thr Leu Ile 
    1115                 1120                 1125             


Asp Gln  Gln Val Val Tyr Ile  His Pro Ser Ser Ala  Leu Phe Asn 
    1130                 1135                 1140             


Arg Gln  Pro Glu Trp Val Val  Tyr His Glu Leu Val  Leu Thr Thr 
    1145                 1150                 1155             


Lys Glu  Tyr Met Arg Glu Val  Thr Thr Ile Asp Pro  Arg Trp Leu 
    1160                 1165                 1170             


Val Glu  Phe Ala Pro Ala Phe  Phe Lys Val Ser Asp  Pro Thr Lys 
    1175                 1180                 1185             


Leu Ser  Lys Gln Lys Lys Gln  Gln Arg Leu Glu Pro  Leu Tyr Asn 
    1190                 1195                 1200             


Arg Tyr  Glu Glu Pro Asn Ala  Trp Arg Ile Ser Arg  Ala Phe Arg 
    1205                 1210                 1215             


Arg Arg  
    1220 


<210>  4231
<211>  1181
<212>  PRT
<213>  Homo Sapiens

<400>  4231

Met Ala Val Ala Val Ala Met Ala Gly Ala Leu Ile Gly Ser Glu Pro 
1               5                   10                  15      


Gly Pro Ala Glu Glu Leu Ala Lys Leu Glu Tyr Leu Ser Leu Val Ser 
            20                  25                  30          


Lys Val Cys Thr Glu Leu Asp Asn His Leu Gly Ile Asn Asp Lys Asp 
        35                  40                  45              


Leu Ala Glu Phe Val Ile Ser Leu Ala Glu Lys Asn Thr Thr Phe Asp 
    50                  55                  60                  


Thr Phe Lys Ala Ser Leu Val Lys Asn Gly Ala Glu Phe Thr Asp Ser 
65                  70                  75                  80  


Leu Ile Ser Asn Leu Leu Arg Leu Ile Gln Thr Met Arg Pro Pro Ala 
                85                  90                  95      


Lys Pro Ser Thr Ser Lys Asp Pro Val Val Lys Pro Lys Thr Glu Lys 
            100                 105                 110         


Glu Lys Leu Lys Glu Leu Phe Pro Val Leu Cys Gln Pro Asp Asn Pro 
        115                 120                 125             


Ser Val Arg Thr Met Leu Asp Glu Asp Asp Val Lys Val Ala Val Asp 
    130                 135                 140                 


Val Leu Lys Glu Leu Glu Ala Leu Met Pro Ser Ala Ala Gly Gln Glu 
145                 150                 155                 160 


Lys Gln Arg Asp Ala Glu His Arg Asp Arg Thr Lys Lys Lys Lys Arg 
                165                 170                 175     


Ser Arg Ser Arg Asp Arg Asn Arg Asp Arg Asp Arg Asp Arg Glu Arg 
            180                 185                 190         


Asn Arg Asp Arg Asp His Lys Arg Arg His Arg Ser Arg Ser Arg Ser 
        195                 200                 205             


Arg Ser Arg Thr Arg Glu Arg Asn Lys Val Lys Ser Arg Tyr Arg Ser 
    210                 215                 220                 


Arg Ser Arg Ser Gln Ser Pro Pro Lys Asp Arg Lys Asp Arg Asp Lys 
225                 230                 235                 240 


Tyr Gly Glu Arg Asn Leu Asp Arg Trp Arg Asp Lys His Val Asp Arg 
                245                 250                 255     


Pro Pro Pro Glu Glu Pro Thr Ile Gly Asp Ile Tyr Asn Gly Lys Val 
            260                 265                 270         


Thr Ser Ile Met Gln Phe Gly Cys Phe Val Gln Leu Glu Gly Leu Arg 
        275                 280                 285             


Lys Arg Trp Glu Gly Leu Val His Ile Ser Glu Leu Arg Arg Glu Gly 
    290                 295                 300                 


Arg Val Ala Asn Val Ala Asp Val Val Ser Lys Gly Gln Arg Val Lys 
305                 310                 315                 320 


Val Lys Val Leu Ser Phe Thr Gly Thr Lys Thr Ser Leu Ser Met Lys 
                325                 330                 335     


Asp Val Asp Gln Glu Thr Gly Glu Asp Leu Asn Pro Asn Arg Arg Arg 
            340                 345                 350         


Asn Leu Val Gly Glu Thr Asn Glu Glu Thr Ser Met Arg Asn Pro Asp 
        355                 360                 365             


Arg Pro Thr His Leu Ser Leu Val Ser Ala Pro Glu Val Glu Asp Asp 
    370                 375                 380                 


Ser Leu Glu Arg Lys Arg Leu Thr Arg Ile Ser Asp Pro Glu Lys Trp 
385                 390                 395                 400 


Glu Ile Lys Gln Met Ile Ala Ala Asn Val Leu Ser Lys Glu Glu Phe 
                405                 410                 415     


Pro Asp Phe Asp Glu Glu Thr Gly Ile Leu Pro Lys Val Asp Asp Glu 
            420                 425                 430         


Glu Asp Glu Asp Leu Glu Ile Glu Leu Val Glu Glu Glu Pro Pro Phe 
        435                 440                 445             


Leu Arg Gly His Thr Lys Gln Ser Met Asp Met Ser Pro Ile Lys Ile 
    450                 455                 460                 


Val Lys Asn Pro Asp Gly Ser Leu Ser Gln Ala Ala Met Met Gln Ser 
465                 470                 475                 480 


Ala Leu Ala Lys Glu Arg Arg Glu Leu Lys Gln Ala Gln Arg Glu Ala 
                485                 490                 495     


Glu Met Asp Ser Ile Pro Met Gly Leu Asn Lys His Trp Val Asp Pro 
            500                 505                 510         


Leu Pro Asp Ala Glu Gly Arg Gln Ile Ala Ala Asn Met Arg Gly Ile 
        515                 520                 525             


Gly Met Met Pro Asn Asp Ile Pro Glu Trp Lys Lys His Ala Phe Gly 
    530                 535                 540                 


Gly Asn Lys Ala Ser Tyr Gly Lys Lys Thr Gln Met Ser Ile Leu Glu 
545                 550                 555                 560 


Gln Arg Glu Ser Leu Pro Ile Tyr Lys Leu Lys Glu Gln Leu Val Gln 
                565                 570                 575     


Ala Val His Asp Asn Gln Ile Leu Ile Val Ile Gly Glu Thr Gly Ser 
            580                 585                 590         


Gly Lys Thr Thr Gln Ile Thr Gln Tyr Leu Ala Glu Ala Gly Tyr Thr 
        595                 600                 605             


Ser Arg Gly Lys Ile Gly Cys Thr Gln Pro Arg Arg Val Ala Ala Met 
    610                 615                 620                 


Ser Val Ala Lys Arg Val Ser Glu Glu Phe Gly Cys Cys Leu Gly Gln 
625                 630                 635                 640 


Glu Val Gly Tyr Thr Ile Arg Phe Glu Asp Cys Thr Ser Pro Glu Thr 
                645                 650                 655     


Val Ile Lys Tyr Met Thr Asp Gly Met Leu Leu Arg Glu Cys Leu Ile 
            660                 665                 670         


Asp Pro Asp Leu Thr Gln Tyr Ala Ile Ile Met Leu Asp Glu Ala His 
        675                 680                 685             


Glu Arg Thr Ile His Thr Asp Val Leu Phe Gly Leu Leu Lys Lys Thr 
    690                 695                 700                 


Val Gln Lys Arg Gln Asp Met Lys Leu Ile Val Thr Ser Ala Thr Leu 
705                 710                 715                 720 


Asp Ala Val Lys Phe Ser Gln Tyr Phe Tyr Glu Ala Pro Ile Phe Thr 
                725                 730                 735     


Ile Pro Gly Arg Thr Tyr Pro Val Glu Ile Leu Tyr Thr Lys Glu Pro 
            740                 745                 750         


Glu Thr Asp Tyr Leu Asp Ala Ser Leu Ile Thr Val Met Gln Ile His 
        755                 760                 765             


Leu Thr Glu Pro Pro Gly Asp Ile Leu Val Phe Leu Thr Gly Gln Glu 
    770                 775                 780                 


Glu Ile Asp Thr Ala Cys Glu Ile Leu Tyr Glu Arg Met Lys Ser Leu 
785                 790                 795                 800 


Gly Pro Asp Val Pro Glu Leu Ile Ile Leu Pro Val Tyr Ser Ala Leu 
                805                 810                 815     


Pro Ser Glu Met Gln Thr Arg Ile Phe Asp Pro Ala Pro Pro Gly Ser 
            820                 825                 830         


Arg Lys Val Val Ile Ala Thr Asn Ile Ala Glu Thr Ser Leu Thr Ile 
        835                 840                 845             


Asp Gly Ile Tyr Tyr Val Val Asp Pro Gly Phe Val Lys Gln Lys Val 
    850                 855                 860                 


Tyr Asn Ser Lys Thr Gly Ile Asp Gln Leu Val Val Thr Pro Ile Ser 
865                 870                 875                 880 


Gln Ala Gln Ala Lys Gln Arg Ala Gly Arg Ala Gly Arg Thr Gly Pro 
                885                 890                 895     


Gly Lys Cys Tyr Arg Leu Tyr Thr Glu Arg Ala Tyr Arg Asp Glu Met 
            900                 905                 910         


Leu Thr Thr Asn Val Pro Glu Ile Gln Arg Thr Asn Leu Ala Ser Thr 
        915                 920                 925             


Val Leu Ser Leu Lys Ala Met Gly Ile Asn Asp Leu Leu Ser Phe Asp 
    930                 935                 940                 


Phe Met Asp Ala Pro Pro Met Glu Thr Leu Ile Thr Ala Met Glu Gln 
945                 950                 955                 960 


Leu Tyr Thr Leu Gly Ala Leu Asp Asp Glu Gly Leu Leu Thr Arg Leu 
                965                 970                 975     


Gly Arg Arg Met Ala Glu Phe Pro Leu Glu Pro Met Leu Cys Lys Met 
            980                 985                 990         


Leu Ile Met Ser Val His Leu Gly  Cys Ser Glu Glu Met  Leu Thr Ile 
        995                 1000                 1005             


Val Ser  Met Leu Ser Val Gln  Asn Val Phe Tyr Arg  Pro Lys Asp 
    1010                 1015                 1020             


Lys Gln  Ala Leu Ala Asp Gln  Lys Lys Ala Lys Phe  His Gln Thr 
    1025                 1030                 1035             


Glu Gly  Asp His Leu Thr Leu  Leu Ala Val Tyr Asn  Ser Trp Lys 
    1040                 1045                 1050             


Asn Asn  Lys Phe Ser Asn Pro  Trp Cys Tyr Glu Asn  Phe Ile Gln 
    1055                 1060                 1065             


Ala Arg  Ser Leu Arg Arg Ala  Gln Asp Ile Arg Lys  Gln Met Leu 
    1070                 1075                 1080             


Gly Ile  Met Asp Arg His Lys  Leu Asp Val Val Ser  Cys Gly Lys 
    1085                 1090                 1095             


Ser Thr  Val Arg Val Gln Lys  Ala Ile Cys Ser Gly  Phe Phe Arg 
    1100                 1105                 1110             


Asn Ala  Ala Lys Lys Asp Pro  Gln Glu Gly Tyr Arg  Thr Leu Ile 
    1115                 1120                 1125             


Asp Gln  Gln Val Val Tyr Ile  His Pro Ser Ser Ala  Leu Phe Asn 
    1130                 1135                 1140             


Arg Gln  Pro Glu Cys Pro Lys  His Phe Leu Pro Val  Val Ala Val 
    1145                 1150                 1155             


Ala Val  Ser Leu Glu Gln Cys  Leu Ser Lys Phe Glu  Asp Leu Asn 
    1160                 1165                 1170             


Lys Glu  Leu Gly Leu Val Thr  Cys 
    1175                 1180     


<210>  4232
<211>  53
<212>  PRT
<213>  Homo Sapiens

<400>  4232

Met Ala Val Ala Val Ala Met Ala Gly Ala Leu Ile Gly Ser Glu Pro 
1               5                   10                  15      


Gly Pro Ala Glu Glu Leu Ala Lys Leu Glu Tyr Leu Ser Leu Val Ser 
            20                  25                  30          


Lys Val Cys Thr Glu Leu Asp Asn His Leu Gly Ile Asn Asp Lys Asp 
        35                  40                  45              


Leu Gly Phe Ser Tyr 
    50              


<210>  4233
<211>  33
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4233

Xaa Tyr Arg Thr Leu Ile Asp Gln Gln Val Val Tyr Ile His Pro Ser 
1               5                   10                  15      


Ser Ala Leu Phe Asn Arg Gln Pro Glu Trp Thr Val Pro Met Gly His 
            20                  25                  30          


Val 
    


<210>  4234
<211>  6
<212>  PRT
<213>  Homo Sapiens

<400>  4234

Met Gly Ile Leu Ser Val 
1               5       


<210>  4235
<211>  6
<212>  PRT
<213>  Homo Sapiens

<400>  4235

Met Gly Ile Leu Ser Val 
1               5       


<210>  4236
<211>  56
<212>  PRT
<213>  Homo Sapiens

<400>  4236

Met Gly Ile Leu Ser Val Asp Leu Leu Ile Thr Leu Gln Ile Leu Pro 
1               5                   10                  15      


Pro Ser Ala Asn Trp Trp Lys Ser Ser Pro Gln Trp Leu Thr Ser Cys 
            20                  25                  30          


Trp Ser Thr Leu Met Arg Leu Ile His Gln Met Ala Gly Arg Tyr Arg 
        35                  40                  45              


Gly Thr Pro Leu Cys Leu Leu Arg 
    50                  55      


<210>  4237
<211>  55
<212>  PRT
<213>  Homo Sapiens

<400>  4237

Met Gly Ile Leu Ser Val Asp Leu Leu Ile Thr Leu Gln Ile Leu Pro 
1               5                   10                  15      


Val Phe Phe Ser Asn Cys Leu Phe Leu Ala Leu Tyr Asp Ser Val Ile 
            20                  25                  30          


Leu Leu Lys His Val Val Leu Leu Leu Ser Arg Ser Lys Ser Thr Arg 
        35                  40                  45              


Gly Glu Trp Arg Arg Met Leu 
    50                  55  


<210>  4238
<211>  145
<212>  PRT
<213>  Homo Sapiens

<400>  4238

Met Gly Ile Leu Ser Val Asp Leu Leu Ile Thr Leu Gln Ile Leu Pro 
1               5                   10                  15      


Val Phe Phe Ser Asn Cys Leu Phe Leu Ala Leu Tyr Asp Ser Val Ile 
            20                  25                  30          


Leu Leu Lys His Val Val Leu Leu Leu Ser Arg Ser Lys Ser Thr Arg 
        35                  40                  45              


Gly Glu Trp Arg Arg Met Leu Thr Ser Glu Gly Leu Arg Cys Val Trp 
    50                  55                  60                  


Lys Ser Phe Leu Leu Asp Ala Tyr Lys Gln Leu Asn Cys Pro Pro Ser 
65                  70                  75                  80  


Gly Phe Ser Lys Asp Gly His Ile Leu Leu Val Tyr Glu Ala Tyr Lys 
                85                  90                  95      


Ser Arg Leu Leu Val Tyr Ser His Leu Asp Leu Trp Met Thr Asp Ser 
            100                 105                 110         


Val Val Leu Thr Leu Asn Phe Pro Arg Gln Ile Ser Leu Cys Phe Gly 
        115                 120                 125             


Lys Asn Ser Ala Ala Glu Leu Tyr Ile Val Ser Lys Lys Glu Lys Val 
    130                 135                 140                 


Pro 
145 


<210>  4239
<211>  306
<212>  PRT
<213>  Homo Sapiens

<400>  4239

Met Gly Ile Leu Ser Val Asp Leu Leu Ile Thr Leu Gln Ile Leu Pro 
1               5                   10                  15      


Val Phe Phe Ser Asn Cys Leu Phe Leu Ala Leu Tyr Asp Ser Val Ile 
            20                  25                  30          


Leu Leu Lys His Val Val Leu Leu Leu Ser Arg Ser Lys Ser Thr Arg 
        35                  40                  45              


Gly Glu Trp Arg Arg Met Leu Thr Ser Glu Gly Leu Arg Cys Val Trp 
    50                  55                  60                  


Lys Ser Phe Leu Leu Asp Ala Tyr Lys Gln Leu Asn Cys Pro Pro Ser 
65                  70                  75                  80  


Gly Phe Ser Lys Asp Gly His Ile Leu Leu Val Tyr Glu Ala Tyr Lys 
                85                  90                  95      


Ser Arg Leu Leu Val Tyr Ser His Leu Asp Leu Trp Met Val Lys Leu 
            100                 105                 110         


Gly Glu Asp Ala Pro Asn Ser Ser Val Val His Val Ser Ser Thr Glu 
        115                 120                 125             


Gly Gly Asp Asn Ser Gly Asn Gly Thr Gln Glu Lys Ile Ala Glu Gly 
    130                 135                 140                 


Ala Thr Cys His Leu Leu Asp Phe Ala Ser Pro Glu Arg Pro Leu Val 
145                 150                 155                 160 


Val Asn Phe Gly Ser Ala Thr Pro Pro Phe Thr Ser Gln Leu Pro Ala 
                165                 170                 175     


Phe Arg Lys Leu Val Glu Glu Phe Ser Ser Val Ala Asp Phe Leu Leu 
            180                 185                 190         


Val Tyr Ile Asp Glu Ala His Pro Ser Asp Gly Trp Ala Ile Pro Gly 
        195                 200                 205             


Asp Ser Ser Leu Ser Phe Glu Val Lys Lys His Gln Asn Gln Glu Asp 
    210                 215                 220                 


Arg Cys Ala Ala Ala Gln Gln Leu Leu Glu Arg Phe Ser Leu Pro Pro 
225                 230                 235                 240 


Gln Cys Arg Val Val Ala Asp Arg Met Asp Asn Asn Ala Asn Ile Ala 
                245                 250                 255     


Tyr Gly Val Ala Phe Glu Arg Val Cys Ile Val Gln Arg Gln Lys Ile 
            260                 265                 270         


Ala Tyr Leu Gly Gly Lys Gly Pro Phe Ser Tyr Asn Leu Gln Glu Val 
        275                 280                 285             


Arg His Trp Leu Glu Lys Asn Phe Ser Lys Arg Lys Lys Thr Arg Leu 
    290                 295                 300                 


Ala Gly 
305     


<210>  4240
<211>  271
<212>  PRT
<213>  Homo Sapiens

<400>  4240

Met Gly Ile Leu Ser Val Asp Leu Leu Ile Thr Leu Gln Ile Leu Pro 
1               5                   10                  15      


Val Phe Phe Ser Asn Cys Leu Phe Leu Ala Leu Tyr Asp Ser Val Ile 
            20                  25                  30          


Leu Leu Lys His Val Val Leu Leu Leu Ser Arg Ser Lys Ser Thr Arg 
        35                  40                  45              


Gly Glu Trp Arg Arg Met Leu Thr Ser Glu Gly Leu Arg Cys Val Trp 
    50                  55                  60                  


Lys Ser Phe Leu Leu Asp Ala Tyr Lys Gln Val Lys Leu Gly Glu Asp 
65                  70                  75                  80  


Ala Pro Asn Ser Ser Val Val His Val Ser Ser Thr Glu Gly Gly Asp 
                85                  90                  95      


Asn Ser Gly Asn Gly Thr Gln Glu Lys Ile Ala Glu Gly Ala Thr Cys 
            100                 105                 110         


His Leu Leu Asp Phe Ala Ser Pro Glu Arg Pro Leu Val Val Asn Phe 
        115                 120                 125             


Gly Ser Ala Thr Pro Pro Phe Thr Ser Gln Leu Pro Ala Phe Arg Lys 
    130                 135                 140                 


Leu Val Glu Glu Phe Ser Ser Val Ala Asp Phe Leu Leu Val Tyr Ile 
145                 150                 155                 160 


Asp Glu Ala His Pro Ser Asp Gly Trp Ala Ile Pro Gly Asp Ser Ser 
                165                 170                 175     


Leu Ser Phe Glu Val Lys Lys His Gln Asn Gln Glu Asp Arg Cys Ala 
            180                 185                 190         


Ala Ala Gln Gln Leu Leu Glu Arg Phe Ser Leu Pro Pro Gln Cys Arg 
        195                 200                 205             


Val Val Ala Asp Arg Met Asp Asn Asn Ala Asn Ile Ala Tyr Gly Val 
    210                 215                 220                 


Ala Phe Glu Arg Val Cys Ile Val Gln Arg Gln Lys Ile Ala Tyr Leu 
225                 230                 235                 240 


Gly Gly Lys Gly Pro Phe Ser Tyr Asn Leu Gln Glu Val Arg His Trp 
                245                 250                 255     


Leu Glu Lys Asn Phe Ser Lys Arg Lys Lys Thr Arg Leu Ala Gly 
            260                 265                 270     


<210>  4241
<211>  271
<212>  PRT
<213>  Homo Sapiens

<400>  4241

Met Gly Ile Leu Ser Val Asp Leu Leu Ile Thr Leu Gln Ile Leu Pro 
1               5                   10                  15      


Val Phe Phe Ser Asn Cys Leu Phe Leu Ala Leu Tyr Asp Ser Val Ile 
            20                  25                  30          


Leu Leu Lys His Val Val Leu Leu Leu Ser Arg Ser Lys Ser Thr Arg 
        35                  40                  45              


Gly Glu Trp Arg Arg Met Leu Thr Ser Glu Gly Leu Arg Cys Val Trp 
    50                  55                  60                  


Lys Ser Phe Leu Leu Asp Ala Tyr Lys Gln Val Lys Leu Gly Glu Asp 
65                  70                  75                  80  


Ala Pro Asn Ser Ser Val Val His Val Ser Ser Thr Glu Gly Gly Asp 
                85                  90                  95      


Asn Ser Gly Asn Gly Thr Gln Glu Lys Ile Ala Glu Gly Ala Thr Cys 
            100                 105                 110         


His Leu Leu Asp Phe Ala Ser Pro Glu Arg Pro Leu Val Val Asn Phe 
        115                 120                 125             


Gly Ser Ala Thr Pro Pro Phe Thr Ser Gln Leu Pro Ala Phe Arg Lys 
    130                 135                 140                 


Leu Val Glu Glu Phe Ser Ser Val Ala Asp Phe Leu Leu Val Tyr Ile 
145                 150                 155                 160 


Asp Glu Ala His Pro Ser Asp Gly Trp Ala Ile Pro Gly Asp Ser Ser 
                165                 170                 175     


Leu Ser Phe Glu Val Lys Lys His Gln Asn Gln Glu Asp Arg Cys Ala 
            180                 185                 190         


Ala Ala Gln Gln Leu Leu Glu Arg Phe Ser Leu Pro Pro Gln Cys Arg 
        195                 200                 205             


Val Val Ala Asp Arg Met Asp Asn Asn Ala Asn Ile Ala Tyr Gly Val 
    210                 215                 220                 


Ala Phe Glu Arg Val Cys Ile Val Gln Arg Gln Lys Ile Ala Tyr Leu 
225                 230                 235                 240 


Gly Gly Lys Gly Pro Phe Ser Tyr Asn Leu Gln Glu Val Arg His Trp 
                245                 250                 255     


Leu Glu Lys Asn Phe Ser Lys Arg Lys Lys Thr Arg Leu Ala Gly 
            260                 265                 270     


<210>  4242
<211>  37
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4242

Xaa Met Leu Thr Ser Glu Gly Leu Arg Cys Val Trp Lys Ser Phe Leu 
1               5                   10                  15      


Leu Asp Ala Tyr Lys Gln Leu Asn Cys Pro Pro Ser Gly Phe Ser Lys 
            20                  25                  30          


Asp Gly His Ile Leu 
        35          


<210>  4243
<211>  58
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4243

Xaa Met Leu Thr Ser Glu Gly Leu Arg Cys Val Trp Lys Ser Phe Leu 
1               5                   10                  15      


Leu Asp Ala Tyr Lys Gln Thr Asp Ser Val Val Leu Thr Leu Asn Phe 
            20                  25                  30          


Pro Arg Gln Ile Ser Leu Cys Phe Gly Lys Asn Ser Ala Ala Glu Leu 
        35                  40                  45              


Tyr Ile Val Ser Lys Lys Glu Lys Val Pro 
    50                  55              


<210>  4244
<211>  77
<212>  PRT
<213>  Homo Sapiens

<400>  4244

Met Glu Glu Ala Lys Lys Met Ile Ser Gly Leu Gln Ala Leu Leu Leu 
1               5                   10                  15      


Asn Gly Ser Leu Pro Glu Asp Glu Gln Glu Arg Pro Leu Ala Leu Cys 
            20                  25                  30          


Glu Pro Gly Val Asn Pro Glu Glu Gln Leu Ile Ile Ile Gln Ser Arg 
        35                  40                  45              


Leu Asp Gln Ser Met Glu Glu Asn Gln Asp Leu Lys Lys Glu Leu Leu 
    50                  55                  60                  


Lys Cys Lys Gln Glu Ala Arg Asn Leu Gln Gly Ile Lys 
65                  70                  75          


<210>  4245
<211>  472
<212>  PRT
<213>  Homo Sapiens

<400>  4245

Met Gly Gly Thr Gln Val Lys Cys Leu Thr Ser Pro Ser Pro Ile His 
1               5                   10                  15      


Ser Ala Lys Ser Glu Ser Ile Ile Thr Gln Ser Glu Glu Lys Ala Asp 
            20                  25                  30          


Phe Val Ile Ile Pro Ala Glu Gly Ile Glu Asn Arg Thr Glu Gly Thr 
        35                  40                  45              


Asp Ser Pro Leu Ser Arg Asp Trp Arg Pro Gly Ser Pro Gly Thr Tyr 
    50                  55                  60                  


Leu Glu Thr Ser Trp Glu Glu Gln Leu Leu Glu Gln Gln Glu Tyr Leu 
65                  70                  75                  80  


Glu Lys Glu Met Glu Glu Ala Lys Lys Met Ile Ser Gly Leu Gln Ala 
                85                  90                  95      


Leu Leu Leu Asn Gly Ser Leu Pro Glu Asp Glu Gln Glu Arg Pro Leu 
            100                 105                 110         


Ala Leu Cys Glu Pro Gly Val Asn Pro Glu Glu Gln Leu Ile Ile Ile 
        115                 120                 125             


Gln Ser Arg Leu Asp Gln Ser Met Glu Glu Asn Gln Asp Leu Lys Lys 
    130                 135                 140                 


Glu Leu Leu Lys Cys Lys Gln Glu Ala Arg Asn Leu Gln Gly Ile Lys 
145                 150                 155                 160 


Asp Ala Leu Gln Gln Arg Leu Thr Gln Gln Asp Thr Ser Val Leu Gln 
                165                 170                 175     


Leu Lys Gln Glu Leu Leu Arg Ala Asn Met Asp Lys Asp Glu Leu His 
            180                 185                 190         


Asn Gln Asn Val Asp Leu Gln Arg Lys Leu Asp Glu Arg Asn Arg Leu 
        195                 200                 205             


Leu Gly Glu Tyr Lys Lys Glu Leu Gly Gln Lys Asp Arg Leu Leu Gln 
    210                 215                 220                 


Gln His Gln Ala Lys Leu Glu Glu Ala Leu Arg Lys Leu Ser Asp Val 
225                 230                 235                 240 


Ser Tyr His Gln Val Asp Leu Glu Arg Glu Leu Glu His Lys Asp Val 
                245                 250                 255     


Leu Leu Ala His Cys Met Lys Arg Glu Ala Asp Glu Ala Thr Asn Tyr 
            260                 265                 270         


Asn Ser His Asn Ser Gln Ser Asn Gly Phe Leu Leu Pro Thr Ala Gly 
        275                 280                 285             


Lys Gly Ala Thr Ser Val Ser Asn Arg Gly Thr Ser Asp Leu Gln Leu 
    290                 295                 300                 


Val Arg Asp Ala Leu Arg Ser Leu Arg Asn Ser Phe Ser Gly His Asp 
305                 310                 315                 320 


Pro Gln His His Thr Ile Asp Ser Leu Glu Gln Gly Ile Ser Ser Leu 
                325                 330                 335     


Met Glu Arg Leu His Val Met Glu Thr Gln Lys Lys Gln Glu Arg Lys 
            340                 345                 350         


Val Arg Val Lys Ser Pro Arg Thr Gln Val Gly Ser Glu Tyr Arg Glu 
        355                 360                 365             


Ser Trp Pro Pro Asn Ser Lys Leu Pro His Ser Gln Ser Ser Pro Thr 
    370                 375                 380                 


Val Ser Ser Thr Cys Thr Lys Val Leu Tyr Phe Thr Asp Arg Ser Leu 
385                 390                 395                 400 


Thr Pro Phe Met Val Asn Ile Pro Lys Arg Leu Glu Glu Val Thr Leu 
                405                 410                 415     


Lys Asp Phe Lys Ala Ala Ile Asp Arg Glu Gly Asn His Arg Tyr His 
            420                 425                 430         


Phe Lys Ala Leu Asp Pro Glu Phe Gly Thr Val Lys Glu Glu Ile Phe 
        435                 440                 445             


His Asp Asp Asp Ala Ile Pro Gly Trp Glu Gly Lys Ile Val Ala Trp 
    450                 455                 460                 


Val Glu Glu Asp His Gly Glu Asn 
465                 470         


<210>  4246
<211>  218
<212>  PRT
<213>  Homo Sapiens

<400>  4246

Met Gly Thr Gln Val Val Met Arg Phe Asn Asn Ser Leu Leu Pro Thr 
1               5                   10                  15      


Glu Pro Ser Gln Gln Leu Gln Ala Tyr Val Ala Trp Val Asn Ala Gln 
            20                  25                  30          


Leu Lys Lys Arg Pro Ala Val Lys Pro Val Gln Asp Leu Arg Gln Asp 
        35                  40                  45              


Leu Arg Asp Gly Val Ile Leu Ala Tyr Leu Ile Glu Ile Val Ala Gly 
    50                  55                  60                  


Glu Lys Leu Ser Gly Val Gln Leu Ser Pro Gly Asn Gln Gln Glu Met 
65                  70                  75                  80  


Lys Asn Asn Val Glu Lys Val Leu Gln Phe Val Ala Ser Lys Lys Ile 
                85                  90                  95      


Arg Met His Gln Thr Ser Ala Lys Asp Ile Val Asp Gly Asn Leu Lys 
            100                 105                 110         


Ser Ile Met Arg Leu Val Leu Ala Leu Ala Ala His Phe Lys Pro Gly 
        115                 120                 125             


Ser Ser Arg Thr Val Asn Gln Gly Arg Asp Ser Arg Ala Pro Leu Gln 
    130                 135                 140                 


Ser His Arg Pro His Cys Ala Thr Ala Val Ala Gln Gly Ala Ala Ala 
145                 150                 155                 160 


Ala Leu Ala Asp Val Cys His Asp Met Ser Arg Ser Gly Arg Asp Val 
                165                 170                 175     


Phe Arg Tyr Arg Gln Arg Asn Ser Ser Met Asp Glu Glu Ile Glu Asn 
            180                 185                 190         


Pro Tyr Trp Ser Val Arg Ala Leu Val Gln Gln Tyr Glu Gly Gln Gln 
        195                 200                 205             


Arg Ser Pro Ser Glu Ser Ser Cys Ser Arg 
    210                 215             


<210>  4247
<211>  683
<212>  PRT
<213>  Homo Sapiens

<400>  4247

Met Leu Ala Cys Leu Thr Arg Gly Asn Leu Leu Asp Val Leu Gln Glu 
1               5                   10                  15      


Gly Phe Asn Glu Gln Gln Leu Gln Ala Tyr Val Ala Trp Val Asn Ala 
            20                  25                  30          


Gln Leu Lys Lys Arg Pro Ala Val Lys Pro Val Gln Asp Leu Arg Gln 
        35                  40                  45              


Asp Leu Arg Asp Gly Val Ile Leu Ala Tyr Leu Ile Glu Ile Val Ala 
    50                  55                  60                  


Gly Glu Lys Leu Ser Gly Val Gln Leu Ser Pro Gly Asn Gln Gln Glu 
65                  70                  75                  80  


Met Lys Asn Asn Val Glu Lys Val Leu Gln Phe Val Ala Ser Lys Lys 
                85                  90                  95      


Ile Arg Met His Gln Thr Ser Ala Lys Asp Ile Val Asp Gly Asn Leu 
            100                 105                 110         


Lys Ser Ile Met Arg Leu Val Leu Ala Leu Ala Ala His Phe Lys Pro 
        115                 120                 125             


Gly Ser Ser Arg Thr Val Asn Gln Gly Arg Asp Ser Arg Ala Pro Leu 
    130                 135                 140                 


Gln Ser His Arg Pro His Cys Ala Thr Ala Val Ala Gln Gly Ala Ala 
145                 150                 155                 160 


Ala Ala Leu Ala Asp Val Cys His Asp Met Ser Arg Ser Gly Arg Asp 
                165                 170                 175     


Val Phe Arg Tyr Arg Gln Arg Asn Ser Ser Met Asp Glu Glu Ile Glu 
            180                 185                 190         


Asn Pro Tyr Trp Ser Val Arg Ala Leu Val Gln Gln Tyr Glu Gly Gln 
        195                 200                 205             


Gln Arg Ser Pro Ser Glu Ser Ser Cys Ser Ser Leu Thr Ser Pro Ser 
    210                 215                 220                 


Pro Ile His Ser Ala Lys Ser Glu Ser Ile Ile Thr Gln Ser Glu Glu 
225                 230                 235                 240 


Lys Ala Asp Phe Val Ile Ile Pro Ala Glu Gly Ile Glu Asn Arg Thr 
                245                 250                 255     


Glu Gly Thr Asp Ser Pro Leu Ser Arg Asp Trp Arg Pro Gly Ser Pro 
            260                 265                 270         


Gly Thr Tyr Leu Glu Thr Ser Trp Glu Glu Gln Leu Leu Glu Gln Gln 
        275                 280                 285             


Glu Tyr Leu Glu Lys Glu Met Glu Glu Ala Lys Lys Met Ile Ser Gly 
    290                 295                 300                 


Leu Gln Ala Leu Leu Leu Asn Gly Ser Leu Pro Glu Asp Glu Gln Glu 
305                 310                 315                 320 


Arg Pro Leu Ala Leu Cys Glu Pro Gly Val Asn Pro Glu Glu Gln Leu 
                325                 330                 335     


Ile Ile Ile Gln Ser Arg Leu Asp Gln Ser Met Glu Glu Asn Gln Asp 
            340                 345                 350         


Leu Lys Lys Glu Leu Leu Lys Cys Lys Gln Glu Ala Arg Asn Leu Gln 
        355                 360                 365             


Gly Ile Lys Asp Ala Leu Gln Gln Arg Leu Thr Gln Gln Asp Thr Ser 
    370                 375                 380                 


Val Leu Gln Leu Lys Gln Glu Leu Leu Arg Ala Asn Met Asp Lys Asp 
385                 390                 395                 400 


Glu Leu His Asn Gln Asn Val Asp Leu Gln Arg Lys Leu Asp Glu Arg 
                405                 410                 415     


Asn Arg Leu Leu Gly Glu Tyr Lys Lys Glu Leu Gly Gln Lys Asp Arg 
            420                 425                 430         


Leu Leu Gln Gln His Gln Ala Lys Leu Glu Glu Ala Leu Arg Lys Leu 
        435                 440                 445             


Ser Asp Val Ser Tyr His Gln Val Asp Leu Glu Arg Glu Leu Glu His 
    450                 455                 460                 


Lys Asp Val Leu Leu Ala His Cys Met Lys Arg Glu Ala Asp Glu Ala 
465                 470                 475                 480 


Thr Asn Tyr Asn Ser His Asn Ser Gln Ser Asn Gly Phe Leu Leu Pro 
                485                 490                 495     


Thr Ala Gly Lys Gly Ala Thr Ser Val Ser Asn Arg Gly Thr Ser Asp 
            500                 505                 510         


Leu Gln Leu Val Arg Asp Ala Leu Arg Ser Leu Arg Asn Ser Phe Ser 
        515                 520                 525             


Gly His Asp Pro Gln His His Thr Ile Asp Ser Leu Glu Gln Gly Ile 
    530                 535                 540                 


Ser Ser Leu Met Glu Arg Leu His Val Met Glu Thr Gln Lys Lys Gln 
545                 550                 555                 560 


Glu Arg Lys Val Arg Val Lys Ser Pro Arg Thr Gln Val Gly Ser Glu 
                565                 570                 575     


Tyr Arg Glu Ser Trp Pro Pro Asn Ser Lys Leu Pro His Ser Gln Ser 
            580                 585                 590         


Ser Pro Thr Val Ser Ser Thr Cys Thr Lys Val Leu Tyr Phe Thr Asp 
        595                 600                 605             


Arg Ser Leu Thr Pro Phe Met Val Asn Ile Pro Lys Arg Leu Glu Glu 
    610                 615                 620                 


Val Thr Leu Lys Asp Phe Lys Ala Ala Ile Asp Arg Glu Gly Asn His 
625                 630                 635                 640 


Arg Tyr His Phe Lys Ala Leu Asp Pro Glu Phe Gly Thr Val Lys Glu 
                645                 650                 655     


Glu Ile Phe His Asp Asp Asp Ala Ile Pro Gly Trp Glu Gly Lys Ile 
            660                 665                 670         


Val Ala Trp Val Glu Glu Asp His Gly Glu Asn 
        675                 680             


<210>  4248
<211>  266
<212>  PRT
<213>  Homo Sapiens

<400>  4248

Met Met Ala Leu Gly Ala Ala Gly Ala Thr Arg Val Phe Val Ala Met 
1               5                   10                  15      


Val Ala Ala Ala Leu Gly Gly His Pro Leu Leu Gly Val Ser Ala Thr 
            20                  25                  30          


Leu Asn Ser Val Leu Asn Ser Asn Ala Ile Lys Asn Leu Pro Pro Pro 
        35                  40                  45              


Leu Gly Gly Ala Ala Gly His Pro Gly Ser Ala Val Ser Ala Ala Pro 
    50                  55                  60                  


Gly Ile Leu Tyr Pro Gly Gly Asn Lys Tyr Gln Thr Ile Asp Asn Tyr 
65                  70                  75                  80  


Gln Pro Tyr Pro Cys Ala Glu Asp Glu Glu Cys Gly Thr Asp Glu Tyr 
                85                  90                  95      


Cys Ala Ser Pro Thr Arg Gly Gly Asp Ala Gly Val Gln Ile Cys Leu 
            100                 105                 110         


Ala Cys Arg Lys Arg Arg Lys Arg Cys Met Arg His Ala Met Cys Cys 
        115                 120                 125             


Pro Gly Asn Tyr Cys Lys Asn Gly Ile Cys Val Ser Ser Asp Gln Asn 
    130                 135                 140                 


His Phe Arg Gly Glu Ile Glu Glu Thr Ile Thr Glu Ser Phe Gly Asn 
145                 150                 155                 160 


Asp His Ser Thr Leu Asp Gly Tyr Ser Arg Arg Thr Thr Leu Ser Ser 
                165                 170                 175     


Lys Met Tyr His Thr Lys Gly Gln Glu Gly Ser Val Cys Leu Arg Ser 
            180                 185                 190         


Ser Asp Cys Ala Ser Gly Leu Cys Cys Ala Arg His Phe Trp Ser Lys 
        195                 200                 205             


Ile Cys Lys Pro Val Leu Lys Glu Gly Gln Val Cys Thr Lys His Arg 
    210                 215                 220                 


Arg Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Tyr Cys Gly 
225                 230                 235                 240 


Glu Gly Leu Ser Cys Arg Ile Gln Lys Asp His His Gln Ala Ser Asn 
                245                 250                 255     


Ser Ser Arg Leu His Thr Cys Gln Arg His 
            260                 265     


<210>  4249
<211>  259
<212>  PRT
<213>  Homo Sapiens

<400>  4249

Met Ala Ala Leu Met Arg Ser Lys Asp Ser Ser Cys Cys Leu Leu Leu 
1               5                   10                  15      


Leu Ala Ala Val Leu Met Val Glu Ser Ser Gln Ile Gly Ser Ser Arg 
            20                  25                  30          


Ala Lys Leu Asn Ser Ile Lys Ser Ser Leu Gly Gly Glu Thr Pro Gly 
        35                  40                  45              


Gln Ala Ala Asn Arg Ser Ala Gly Met Tyr Gln Gly Leu Ala Phe Gly 
    50                  55                  60                  


Gly Ser Lys Lys Gly Lys Asn Leu Gly Gln Ala Tyr Pro Cys Ser Ser 
65                  70                  75                  80  


Asp Lys Glu Cys Glu Val Gly Arg Tyr Cys His Ser Pro His Gln Gly 
                85                  90                  95      


Ser Ser Ala Cys Met Val Cys Arg Arg Lys Lys Lys Arg Cys His Arg 
            100                 105                 110         


Asp Gly Met Cys Cys Pro Ser Thr Arg Cys Asn Asn Gly Ile Cys Ile 
        115                 120                 125             


Pro Val Thr Glu Ser Ile Leu Thr Pro His Ile Pro Ala Leu Asp Gly 
    130                 135                 140                 


Thr Arg His Arg Asp Arg Asn His Gly His Tyr Ser Asn His Asp Leu 
145                 150                 155                 160 


Gly Trp Gln Asn Leu Gly Arg Pro His Thr Lys Met Ser His Ile Lys 
                165                 170                 175     


Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys Ile Glu Gly 
            180                 185                 190         


Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys Pro Val Leu 
        195                 200                 205             


His Gln Gly Glu Val Cys Thr Lys Gln Arg Lys Lys Gly Ser His Gly 
    210                 215                 220                 


Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu Ser Cys Lys 
225                 230                 235                 240 


Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu His Val Cys 
                245                 250                 255     


Gln Lys Ile 
            


<210>  4250
<211>  213
<212>  PRT
<213>  Homo Sapiens

<400>  4250

Met Thr Leu Arg Ile Asp Tyr Cys Gln Gly Leu Leu Val Gly Val Ser 
1               5                   10                  15      


Ser Ser Gly Leu Asn Ile Ile Gln Ile Gln Cys Gln Ala Tyr Pro Cys 
            20                  25                  30          


Ser Ser Asp Lys Glu Cys Glu Val Gly Arg Tyr Cys His Ser Pro His 
        35                  40                  45              


Gln Gly Ser Ser Ala Cys Met Val Cys Arg Arg Lys Lys Lys Arg Cys 
    50                  55                  60                  


His Arg Asp Gly Met Cys Cys Pro Ser Thr Arg Cys Asn Asn Gly Ile 
65                  70                  75                  80  


Cys Ile Pro Val Thr Glu Ser Ile Leu Thr Pro His Ile Pro Ala Leu 
                85                  90                  95      


Asp Gly Thr Arg His Arg Asp Arg Asn His Gly His Tyr Ser Asn His 
            100                 105                 110         


Asp Leu Gly Trp Gln Asn Leu Gly Arg Pro His Thr Lys Met Ser His 
        115                 120                 125             


Ile Lys Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys Ile 
    130                 135                 140                 


Glu Gly Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys Pro 
145                 150                 155                 160 


Val Leu His Gln Gly Glu Val Cys Thr Lys Gln Arg Lys Lys Gly Ser 
                165                 170                 175     


His Gly Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu Ser 
            180                 185                 190         


Cys Lys Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu His 
        195                 200                 205             


Val Cys Gln Lys Ile 
    210             


<210>  4251
<211>  159
<212>  PRT
<213>  Homo Sapiens

<400>  4251

Met Val Cys Arg Arg Lys Lys Lys Arg Cys His Arg Asp Gly Met Cys 
1               5                   10                  15      


Cys Pro Ser Thr Arg Cys Asn Asn Gly Ile Cys Ile Pro Val Thr Glu 
            20                  25                  30          


Ser Ile Leu Thr Pro His Ile Pro Ala Leu Asp Gly Thr Arg His Arg 
        35                  40                  45              


Asp Arg Asn His Gly His Tyr Ser Asn His Asp Leu Gly Trp Gln Asn 
    50                  55                  60                  


Leu Gly Arg Pro His Thr Lys Met Ser His Ile Lys Gly His Glu Gly 
65                  70                  75                  80  


Asp Pro Cys Leu Arg Ser Ser Asp Cys Ile Glu Gly Phe Cys Cys Ala 
                85                  90                  95      


Arg His Phe Trp Thr Lys Ile Cys Lys Pro Val Leu His Gln Gly Glu 
            100                 105                 110         


Val Cys Thr Lys Gln Arg Lys Lys Gly Ser His Gly Leu Glu Ile Phe 
        115                 120                 125             


Gln Arg Cys Asp Cys Ala Lys Gly Leu Ser Cys Lys Val Trp Lys Asp 
    130                 135                 140                 


Ala Thr Tyr Ser Ser Lys Ala Arg Leu His Val Cys Gln Lys Ile 
145                 150                 155                 


<210>  4252
<211>  132
<212>  PRT
<213>  Homo Sapiens

<400>  4252

Met Gln Arg Leu Gly Ala Thr Leu Leu Cys Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Val Pro Thr Ala Pro Ala Pro Ala Pro Thr Ala Thr Ser Ala Pro Val 
            20                  25                  30          


Lys Pro Gly Pro Ala Leu Ser Tyr Pro Gln Glu Glu Ala Thr Leu Asn 
        35                  40                  45              


Glu Met Phe Arg Glu Val Glu Glu Leu Met Glu Asp Thr Gln His Lys 
    50                  55                  60                  


Leu Arg Ser Ala Val Glu Glu Met Glu Ala Glu Glu Ala Ala Ala Lys 
65                  70                  75                  80  


Ala Ser Ser Glu Val Asn Leu Ala Asn Leu Pro Pro Ser Tyr His Asn 
                85                  90                  95      


Glu Thr Asn Thr Asp Thr Lys Val Gly Asn Asn Thr Ile His Val His 
            100                 105                 110         


Arg Glu Ile His Lys Glu Cys Ile Ile Asp Glu Asp Cys Gly Pro Ser 
        115                 120                 125             


Met Tyr Cys Gln 
    130         


<210>  4253
<211>  183
<212>  PRT
<213>  Homo Sapiens

<400>  4253

Met Gln Arg Leu Gly Ala Thr Leu Leu Cys Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Val Pro Thr Ala Pro Ala Pro Ala Pro Thr Ala Thr Ser Ala Pro Val 
            20                  25                  30          


Lys Pro Gly Pro Ala Leu Ser Tyr Pro Gln Glu Glu Ala Thr Leu Asn 
        35                  40                  45              


Glu Met Phe Arg Glu Val Glu Glu Leu Met Glu Asp Thr Gln His Lys 
    50                  55                  60                  


Leu Arg Ser Ala Val Glu Glu Met Glu Ala Glu Glu Ala Ala Ala Lys 
65                  70                  75                  80  


Ala Ser Ser Glu Val Asn Leu Ala Asn Leu Pro Pro Ser Tyr His Asn 
                85                  90                  95      


Glu Thr Asn Thr Asp Thr Lys Val Gly Asn Asn Thr Ile His Val His 
            100                 105                 110         


Arg Glu Ile His Lys Glu Cys Ile Ile Asp Glu Asp Cys Gly Pro Ser 
        115                 120                 125             


Met Tyr Cys Gln Phe Ala Ser Phe Gln Tyr Thr Cys Gln Pro Cys Arg 
    130                 135                 140                 


Gly Gln Arg Met Leu Cys Thr Arg Asp Ser Glu Cys Cys Gly Asp Gln 
145                 150                 155                 160 


Leu Cys Val Trp Gly His Cys Thr Lys Met Ala Thr Arg Gly Ser Asn 
                165                 170                 175     


Gly Thr Ile Cys Asp Asn Gln 
            180             


<210>  4254
<211>  235
<212>  PRT
<213>  Homo Sapiens

<400>  4254

Met Gln Arg Leu Gly Ala Thr Leu Leu Cys Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Val Pro Thr Ala Pro Ala Pro Ala Pro Thr Ala Thr Ser Ala Pro Val 
            20                  25                  30          


Lys Pro Gly Pro Ala Leu Ser Tyr Pro Gln Glu Glu Ala Thr Leu Asn 
        35                  40                  45              


Glu Met Phe Arg Glu Val Glu Glu Leu Met Glu Asp Thr Gln His Lys 
    50                  55                  60                  


Leu Arg Ser Ala Val Glu Glu Met Glu Ala Glu Glu Ala Ala Ala Lys 
65                  70                  75                  80  


Ala Ser Ser Glu Val Asn Leu Ala Asn Leu Pro Pro Ser Tyr His Asn 
                85                  90                  95      


Glu Thr Asn Thr Asp Thr Lys Val Gly Asn Asn Thr Ile His Val His 
            100                 105                 110         


Arg Glu Ile His Lys Ile Thr Asn Asn Gln Thr Gly Gln Met Val Phe 
        115                 120                 125             


Ser Glu Thr Val Ile Thr Ser Val Gly Asp Glu Glu Gly Arg Arg Ser 
    130                 135                 140                 


His Glu Cys Ile Ile Asp Glu Asp Cys Gly Pro Ser Met Tyr Cys Gln 
145                 150                 155                 160 


Phe Ala Ser Phe Gln Tyr Thr Cys Gln Pro Cys Arg Gly Gln Arg Met 
                165                 170                 175     


Leu Cys Thr Arg Asp Ser Glu Cys Cys Gly Asp Gln Leu Cys Val Trp 
            180                 185                 190         


Gly His Cys Thr Lys Met Ala Thr Arg Gly Ser Asn Gly Thr Ile Cys 
        195                 200                 205             


Asp Asn Gln Arg Asp Cys Gln Pro Gly Leu Cys Cys Ala Phe Gln Arg 
    210                 215                 220                 


Gly Leu Leu Phe Pro Val Cys Thr Pro Leu Pro 
225                 230                 235 


<210>  4255
<211>  350
<212>  PRT
<213>  Homo Sapiens

<400>  4255

Met Gln Arg Leu Gly Ala Thr Leu Leu Cys Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Val Pro Thr Ala Pro Ala Pro Ala Pro Thr Ala Thr Ser Ala Pro Val 
            20                  25                  30          


Lys Pro Gly Pro Ala Leu Ser Tyr Pro Gln Glu Glu Ala Thr Leu Asn 
        35                  40                  45              


Glu Met Phe Arg Glu Val Glu Glu Leu Met Glu Asp Thr Gln His Lys 
    50                  55                  60                  


Leu Arg Ser Ala Val Glu Glu Met Glu Ala Glu Glu Ala Ala Ala Lys 
65                  70                  75                  80  


Ala Ser Ser Glu Val Asn Leu Ala Asn Leu Pro Pro Ser Tyr His Asn 
                85                  90                  95      


Glu Thr Asn Thr Asp Thr Lys Val Gly Asn Asn Thr Ile His Val His 
            100                 105                 110         


Arg Glu Ile His Lys Ile Thr Asn Asn Gln Thr Gly Gln Met Val Phe 
        115                 120                 125             


Ser Glu Thr Val Ile Thr Ser Val Gly Asp Glu Glu Gly Arg Arg Ser 
    130                 135                 140                 


His Glu Cys Ile Ile Asp Glu Asp Cys Gly Pro Ser Met Tyr Cys Gln 
145                 150                 155                 160 


Phe Ala Ser Phe Gln Tyr Thr Cys Gln Pro Cys Arg Gly Gln Arg Met 
                165                 170                 175     


Leu Cys Thr Arg Asp Ser Glu Cys Cys Gly Asp Gln Leu Cys Val Trp 
            180                 185                 190         


Gly His Cys Thr Lys Met Ala Thr Arg Gly Ser Asn Gly Thr Ile Cys 
        195                 200                 205             


Asp Asn Gln Arg Asp Cys Gln Pro Gly Leu Cys Cys Ala Phe Gln Arg 
    210                 215                 220                 


Gly Leu Leu Phe Pro Val Cys Thr Pro Leu Pro Val Glu Gly Glu Leu 
225                 230                 235                 240 


Cys His Asp Pro Ala Ser Arg Leu Leu Asp Leu Ile Thr Trp Glu Leu 
                245                 250                 255     


Glu Pro Asp Gly Ala Leu Asp Arg Cys Pro Cys Ala Ser Gly Leu Leu 
            260                 265                 270         


Cys Gln Pro His Ser His Ser Leu Val Tyr Val Cys Lys Pro Thr Phe 
        275                 280                 285             


Val Gly Ser Arg Asp Gln Asp Gly Glu Ile Leu Leu Pro Arg Glu Val 
    290                 295                 300                 


Pro Asp Glu Tyr Glu Val Gly Ser Phe Met Glu Glu Val Arg Gln Glu 
305                 310                 315                 320 


Leu Glu Asp Leu Glu Arg Ser Leu Thr Glu Glu Met Ala Leu Arg Glu 
                325                 330                 335     


Pro Ala Ala Ala Ala Ala Ala Leu Leu Gly Gly Glu Glu Ile 
            340                 345                 350 


<210>  4256
<211>  350
<212>  PRT
<213>  Homo Sapiens

<400>  4256

Met Gln Arg Leu Gly Ala Thr Leu Leu Cys Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Val Pro Thr Ala Pro Ala Pro Ala Pro Thr Ala Thr Ser Ala Pro Val 
            20                  25                  30          


Lys Pro Gly Pro Ala Leu Ser Tyr Pro Gln Glu Glu Ala Thr Leu Asn 
        35                  40                  45              


Glu Met Phe Arg Glu Val Glu Glu Leu Met Glu Asp Thr Gln His Lys 
    50                  55                  60                  


Leu Arg Ser Ala Val Glu Glu Met Glu Ala Glu Glu Ala Ala Ala Lys 
65                  70                  75                  80  


Ala Ser Ser Glu Val Asn Leu Ala Asn Leu Pro Pro Ser Tyr His Asn 
                85                  90                  95      


Glu Thr Asn Thr Asp Thr Lys Val Gly Asn Asn Thr Ile His Val His 
            100                 105                 110         


Arg Glu Ile His Lys Ile Thr Asn Asn Gln Thr Gly Gln Met Val Phe 
        115                 120                 125             


Ser Glu Thr Val Ile Thr Ser Val Gly Asp Glu Glu Gly Arg Arg Ser 
    130                 135                 140                 


His Glu Cys Ile Ile Asp Glu Asp Cys Gly Pro Ser Met Tyr Cys Gln 
145                 150                 155                 160 


Phe Ala Ser Phe Gln Tyr Thr Cys Gln Pro Cys Arg Gly Gln Arg Met 
                165                 170                 175     


Leu Cys Thr Arg Asp Ser Glu Cys Cys Gly Asp Gln Leu Cys Val Trp 
            180                 185                 190         


Gly His Cys Thr Lys Met Ala Thr Arg Gly Ser Asn Gly Thr Ile Cys 
        195                 200                 205             


Asp Asn Gln Arg Asp Cys Gln Pro Gly Leu Cys Cys Ala Phe Gln Arg 
    210                 215                 220                 


Gly Leu Leu Phe Pro Val Cys Thr Pro Leu Pro Val Glu Gly Glu Leu 
225                 230                 235                 240 


Cys His Asp Pro Ala Ser Arg Leu Leu Asp Leu Ile Thr Trp Glu Leu 
                245                 250                 255     


Glu Pro Asp Gly Ala Leu Asp Arg Cys Pro Cys Ala Ser Gly Leu Leu 
            260                 265                 270         


Cys Gln Pro His Ser His Ser Leu Val Tyr Val Cys Lys Pro Thr Phe 
        275                 280                 285             


Val Gly Ser Arg Asp Gln Asp Gly Glu Ile Leu Leu Pro Arg Glu Val 
    290                 295                 300                 


Pro Asp Glu Tyr Glu Val Gly Ser Phe Met Glu Glu Val Arg Gln Glu 
305                 310                 315                 320 


Leu Glu Asp Leu Glu Arg Ser Leu Thr Glu Glu Met Ala Leu Arg Glu 
                325                 330                 335     


Pro Ala Ala Ala Ala Ala Ala Leu Leu Gly Gly Glu Glu Ile 
            340                 345                 350 


<210>  4257
<211>  364
<212>  PRT
<213>  Homo Sapiens

<400>  4257

Met Gln Arg Leu Gly Ala Thr Leu Leu Cys Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Val Pro Thr Ala Pro Ala Pro Ala Pro Thr Ala Thr Ser Ala Pro Val 
            20                  25                  30          


Lys Pro Gly Pro Ala Leu Ser Tyr Pro Gln Glu Glu Ala Thr Leu Asn 
        35                  40                  45              


Glu Met Phe Arg Glu Val Glu Glu Leu Met Glu Asp Thr Gln His Lys 
    50                  55                  60                  


Leu Arg Ser Ala Val Glu Glu Met Glu Ala Glu Glu Ala Ala Ala Lys 
65                  70                  75                  80  


Ala Ser Ser Glu Val Asn Leu Ala Asn Leu Pro Pro Ser Tyr His Asn 
                85                  90                  95      


Glu Thr Asn Thr Asp Thr Lys Val Gly Asn Asn Thr Ile His Val His 
            100                 105                 110         


Arg Glu Ile His Lys Ile Thr Asn Asn Gln Thr Gly Gln Met Val Phe 
        115                 120                 125             


Ser Glu Thr Val Ile Thr Ser Val Gly Asp Glu Glu Gly Arg Arg Ser 
    130                 135                 140                 


His Glu Cys Ile Ile Asp Glu Asp Cys Gly Pro Ser Met Tyr Cys Gln 
145                 150                 155                 160 


Phe Ala Ser Phe Gln Tyr Thr Cys Gln Pro Cys Arg Gly Gln Arg Met 
                165                 170                 175     


Leu Cys Thr Arg Asp Ser Glu Cys Cys Gly Asp Gln Leu Cys Val Trp 
            180                 185                 190         


Gly His Cys Thr Lys Met Ala Thr Arg Gly Ser Asn Gly Thr Ile Cys 
        195                 200                 205             


Asp Asn Gln Arg Asp Cys Gln Pro Gly Leu Cys Cys Ala Phe Gln Arg 
    210                 215                 220                 


Gly Leu Leu Phe Pro Val Cys Thr Pro Leu Pro Val Glu Gly Glu Leu 
225                 230                 235                 240 


Cys His Asp Pro Ala Ser Arg Leu Leu Asp Leu Ile Thr Trp Glu Leu 
                245                 250                 255     


Glu Pro Asp Gly Ala Leu Asp Arg Cys Pro Cys Ala Ser Gly Leu Leu 
            260                 265                 270         


Cys Gln Pro His Arg Leu Pro Arg Leu Glu Pro Gly Phe Val Pro Ser 
        275                 280                 285             


Leu Pro Ser His Ser Leu Val Tyr Val Cys Lys Pro Thr Phe Val Gly 
    290                 295                 300                 


Ser Arg Asp Gln Asp Gly Glu Ile Leu Leu Pro Arg Glu Val Pro Asp 
305                 310                 315                 320 


Glu Tyr Glu Val Gly Ser Phe Met Glu Glu Val Arg Gln Glu Leu Glu 
                325                 330                 335     


Asp Leu Glu Arg Ser Leu Thr Glu Glu Met Ala Leu Arg Glu Pro Ala 
            340                 345                 350         


Ala Ala Ala Ala Ala Leu Leu Gly Gly Glu Glu Ile 
        355                 360                 


<210>  4258
<211>  224
<212>  PRT
<213>  Homo Sapiens

<400>  4258

Met Val Ala Ala Val Leu Leu Gly Leu Ser Trp Leu Cys Ser Pro Leu 
1               5                   10                  15      


Gly Ala Leu Val Leu Asp Phe Asn Asn Ile Arg Ser Ser Ala Asp Leu 
            20                  25                  30          


His Gly Ala Arg Lys Gly Ser Gln Cys Leu Ser Asp Thr Asp Cys Asn 
        35                  40                  45              


Thr Arg Lys Phe Cys Leu Gln Pro Arg Asp Glu Lys Pro Phe Cys Ala 
    50                  55                  60                  


Thr Cys Arg Gly Leu Arg Arg Arg Cys Gln Arg Asp Ala Met Cys Cys 
65                  70                  75                  80  


Pro Gly Thr Leu Cys Val Asn Asp Val Cys Thr Thr Met Glu Asp Ala 
                85                  90                  95      


Thr Pro Ile Leu Glu Arg Gln Leu Asp Glu Gln Asp Gly Thr His Ala 
            100                 105                 110         


Glu Gly Thr Thr Gly His Pro Val Gln Glu Asn Gln Pro Lys Arg Lys 
        115                 120                 125             


Pro Ser Ile Lys Lys Ser Gln Gly Arg Lys Gly Gln Glu Gly Glu Ser 
    130                 135                 140                 


Cys Leu Arg Thr Phe Asp Cys Gly Pro Gly Leu Cys Cys Ala Arg His 
145                 150                 155                 160 


Phe Trp Thr Lys Ile Cys Lys Pro Val Leu Leu Glu Gly Gln Val Cys 
                165                 170                 175     


Ser Arg Arg Gly His Lys Asp Thr Ala Gln Ala Pro Glu Ile Phe Gln 
            180                 185                 190         


Arg Cys Asp Cys Gly Pro Gly Leu Leu Cys Arg Ser Gln Leu Thr Ser 
        195                 200                 205             


Asn Arg Gln His Ala Arg Leu Arg Val Cys Gln Lys Ile Glu Lys Leu 
    210                 215                 220                 


<210>  4259
<211>  125
<212>  PRT
<213>  Homo Sapiens

<400>  4259

Met Asp Phe Arg Gly Leu Pro Gly Asn Tyr His Lys Glu Glu Asn Gln 
1               5                   10                  15      


Glu His Gln Leu Gly Asn Asn Thr Leu Ser Ser His Leu Gln Ile Asp 
            20                  25                  30          


Lys Met Thr Asp Asn Lys Thr Gly Glu Val Leu Ile Ser Glu Asn Val 
        35                  40                  45              


Val Ala Ser Ile Gln Pro Ala Glu Gly Ser Phe Glu Gly Asp Leu Lys 
    50                  55                  60                  


Val Pro Arg Met Glu Glu Lys Glu Ala Leu Val Pro Ile Gln Lys Ala 
65                  70                  75                  80  


Thr Asp Ser Phe His Thr Glu Leu His Pro Arg Val Ala Phe Trp Ile 
                85                  90                  95      


Ile Lys Leu Pro Arg Arg Arg Ser His Gln Asp Ala Leu Glu Gly Gly 
            100                 105                 110         


His Trp Leu Ser Glu Lys Arg His Arg Leu Gln Ala Ile 
        115                 120                 125 


<210>  4260
<211>  146
<212>  PRT
<213>  Homo Sapiens

<400>  4260

Met Asp Phe Arg Gly Leu Pro Gly Asn Tyr His Lys Glu Glu Asn Gln 
1               5                   10                  15      


Glu His Gln Leu Gly Asn Asn Thr Leu Ser Ser His Leu Gln Ile Asp 
            20                  25                  30          


Lys Met Thr Asp Asn Lys Thr Gly Glu Val Leu Ile Ser Glu Asn Val 
        35                  40                  45              


Val Ala Ser Ile Gln Pro Ala Glu Gly Ser Phe Glu Gly Asp Leu Lys 
    50                  55                  60                  


Val Pro Arg Met Glu Glu Lys Glu Ala Leu Val Pro Ile Gln Lys Ala 
65                  70                  75                  80  


Thr Asp Ser Phe His Thr Glu Leu His Pro Arg Val Ala Phe Trp Ile 
                85                  90                  95      


Ile Lys Leu Pro Arg Arg Arg Ser His Gln Asp Ala Leu Glu Gly Gly 
            100                 105                 110         


His Trp Leu Ser Glu Lys Arg His Arg Leu Gln Ala Ile Arg Asp Gly 
        115                 120                 125             


Leu Arg Lys Gly Thr His Lys Asp Val Leu Glu Glu Gly Thr Glu Ser 
    130                 135                 140                 


Ser Ser 
145     


<210>  4261
<211>  100
<212>  PRT
<213>  Homo Sapiens

<400>  4261

Met Glu Glu Lys Glu Ala Leu Val Pro Ile Gln Lys Ala Thr Asp Ser 
1               5                   10                  15      


Phe His Thr Glu Leu His Pro Arg Val Ala Phe Trp Ile Ile Lys Leu 
            20                  25                  30          


Pro Arg Arg Arg Ser His Gln Asp Ala Leu Glu Gly Gly His Trp Leu 
        35                  40                  45              


Ser Glu Lys Arg His Arg Leu Gln Ala Ile Arg Asp Gly Leu Arg Lys 
    50                  55                  60                  


Gly Thr His Lys Asp Val Leu Glu Glu Gly Thr Glu Ser Ser Ser His 
65                  70                  75                  80  


Ser Arg Leu Ser Pro Arg Lys Thr His Leu Leu Tyr Ile Leu Arg Pro 
                85                  90                  95      


Ser Arg Gln Leu 
            100 


<210>  4262
<211>  242
<212>  PRT
<213>  Homo Sapiens

<400>  4262

Met Gly Glu Ala Ser Pro Pro Ala Pro Ala Arg Arg His Leu Leu Val 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ser Thr Leu Val Ile Pro Ser Ala Ala Ala Pro 
            20                  25                  30          


Ile His Asp Ala Asp Ala Gln Glu Ser Ser Leu Gly Leu Thr Gly Leu 
        35                  40                  45              


Gln Ser Leu Leu Gln Gly Phe Ser Arg Leu Phe Leu Lys Gly Asn Leu 
    50                  55                  60                  


Leu Arg Gly Ile Asp Ser Leu Phe Ser Ala Pro Met Asp Phe Arg Gly 
65                  70                  75                  80  


Leu Pro Gly Asn Tyr His Lys Glu Glu Asn Gln Glu His Gln Leu Gly 
                85                  90                  95      


Asn Asn Thr Leu Ser Ser His Leu Gln Ile Asp Lys Met Thr Asp Asn 
            100                 105                 110         


Lys Thr Gly Glu Val Leu Ile Ser Glu Asn Val Val Ala Ser Ile Gln 
        115                 120                 125             


Pro Ala Glu Gly Ser Phe Glu Gly Asp Leu Lys Val Pro Arg Met Glu 
    130                 135                 140                 


Glu Lys Glu Ala Leu Val Pro Ile Gln Lys Ala Thr Asp Ser Phe His 
145                 150                 155                 160 


Thr Glu Leu His Pro Arg Val Ala Phe Trp Ile Ile Lys Leu Pro Arg 
                165                 170                 175     


Arg Arg Ser His Gln Asp Ala Leu Glu Gly Gly His Trp Leu Ser Glu 
            180                 185                 190         


Lys Arg His Arg Leu Gln Ala Ile Arg Asp Gly Leu Arg Lys Gly Thr 
        195                 200                 205             


His Lys Asp Val Leu Glu Glu Gly Thr Glu Ser Ser Ser His Ser Arg 
    210                 215                 220                 


Leu Ser Pro Arg Lys Thr His Leu Leu Tyr Ile Leu Arg Pro Ser Arg 
225                 230                 235                 240 


Gln Leu 
        


<210>  4263
<211>  199
<212>  PRT
<213>  Homo Sapiens

<400>  4263

Met Gly Glu Ala Ser Pro Pro Ala Pro Ala Arg Arg His Leu Leu Val 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ser Thr Leu Val Ile Pro Ser Ala Ala Ala Pro 
            20                  25                  30          


Ile His Asp Ala Asp Ala Gln Glu Ser Ser Leu Gly Leu Thr Gly Leu 
        35                  40                  45              


Gln Ser Leu Leu Gln Gly Phe Ser Arg Leu Phe Leu Lys Gly Asn Leu 
    50                  55                  60                  


Leu Arg Gly Ile Asp Ser Leu Phe Ser Ala Pro Met Asp Phe Arg Gly 
65                  70                  75                  80  


Leu Pro Gly Asn Tyr His Lys Glu Glu Asn Gln Glu His Gln Leu Gly 
                85                  90                  95      


Asn Asn Thr Leu Ser Ser His Leu Gln Ile Asp Lys Val Pro Arg Met 
            100                 105                 110         


Glu Glu Lys Glu Ala Leu Val Pro Ile Gln Lys Ala Thr Asp Ser Phe 
        115                 120                 125             


His Thr Glu Leu His Pro Arg Val Ala Phe Trp Ile Ile Lys Leu Pro 
    130                 135                 140                 


Arg Arg Arg Ser His Gln Asp Ala Leu Glu Gly Gly His Trp Leu Ser 
145                 150                 155                 160 


Glu Lys Arg His Arg Leu Gln Ala Ile Arg Asp Gly Leu Arg Lys Gly 
                165                 170                 175     


Thr His Lys Asp Val Leu Glu Glu Gly Thr Glu Ser Ser Ser His Ser 
            180                 185                 190         


Arg Leu Ser Pro Arg Lys Thr 
        195                 


<210>  4264
<211>  137
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4264

Xaa Ala Ala Ala Pro Ile His Asp Ala Asp Ala Gln Glu Ser Ser Leu 
1               5                   10                  15      


Gly Leu Thr Gly Leu Gln Ser Leu Leu Gln Gly Phe Ser Arg Leu Phe 
            20                  25                  30          


Leu Lys Val Pro Arg Met Glu Glu Lys Glu Ala Leu Val Pro Ile Gln 
        35                  40                  45              


Lys Ala Thr Asp Ser Phe His Thr Glu Leu His Pro Arg Val Ala Phe 
    50                  55                  60                  


Trp Ile Ile Lys Leu Pro Arg Arg Arg Ser His Gln Asp Ala Leu Glu 
65                  70                  75                  80  


Gly Gly His Trp Leu Ser Glu Lys Arg His Arg Leu Gln Ala Ile Arg 
                85                  90                  95      


Asp Gly Leu Arg Lys Gly Thr His Lys Asp Val Leu Glu Glu Gly Thr 
            100                 105                 110         


Glu Ser Ser Ser His Ser Arg Leu Ser Pro Arg Lys Thr His Leu Leu 
        115                 120                 125             


Tyr Ile Leu Arg Pro Ser Arg Gln Leu 
    130                 135         


<210>  4265
<211>  724
<212>  PRT
<213>  Homo Sapiens

<400>  4265

Met Asp Cys Leu Cys Ile Val Thr Thr Lys Lys Tyr Arg Tyr Gln Asp 
1               5                   10                  15      


Glu Asp Thr Pro Pro Leu Glu His Ser Pro Ala His Leu Pro Asn Gln 
            20                  25                  30          


Ala Asn Ser Pro Pro Val Ile Val Asn Thr Asp Thr Leu Glu Ala Pro 
        35                  40                  45              


Gly Tyr Glu Leu Gln Val Asn Gly Thr Glu Gly Glu Met Glu Tyr Glu 
    50                  55                  60                  


Glu Ile Thr Leu Glu Arg Gly Asn Ser Gly Leu Gly Phe Ser Ile Ala 
65                  70                  75                  80  


Gly Gly Thr Asp Asn Pro His Ile Gly Asp Asp Pro Ser Ile Phe Ile 
                85                  90                  95      


Thr Lys Ile Ile Pro Gly Gly Ala Ala Ala Gln Asp Gly Arg Leu Arg 
            100                 105                 110         


Val Asn Asp Ser Ile Leu Phe Val Asn Glu Val Asp Val Arg Glu Val 
        115                 120                 125             


Thr His Ser Ala Ala Val Glu Ala Leu Lys Glu Ala Gly Ser Ile Val 
    130                 135                 140                 


Arg Leu Tyr Val Met Arg Arg Lys Pro Pro Ala Glu Lys Val Met Glu 
145                 150                 155                 160 


Ile Lys Leu Ile Lys Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala Gly 
                165                 170                 175     


Gly Val Gly Asn Gln His Ile Pro Gly Asp Asn Ser Ile Tyr Val Thr 
            180                 185                 190         


Lys Ile Ile Glu Gly Gly Ala Ala His Lys Asp Gly Arg Leu Gln Ile 
        195                 200                 205             


Gly Asp Lys Ile Leu Ala Val Asn Ser Val Gly Leu Glu Asp Val Met 
    210                 215                 220                 


His Glu Asp Ala Val Ala Ala Leu Lys Asn Thr Tyr Asp Val Val Tyr 
225                 230                 235                 240 


Leu Lys Val Ala Lys Pro Ser Asn Ala Tyr Leu Ser Asp Ser Tyr Ala 
                245                 250                 255     


Pro Pro Asp Ile Thr Thr Ser Tyr Ser Gln His Leu Asp Asn Glu Ile 
            260                 265                 270         


Ser His Ser Ser Tyr Leu Gly Thr Asp Tyr Pro Thr Ala Met Thr Pro 
        275                 280                 285             


Thr Ser Pro Arg Arg Tyr Ser Pro Val Ala Lys Asp Leu Leu Gly Glu 
    290                 295                 300                 


Glu Asp Ile Pro Arg Glu Pro Arg Arg Ile Val Ile His Arg Gly Ser 
305                 310                 315                 320 


Thr Gly Leu Gly Phe Asn Ile Val Gly Gly Glu Asp Gly Glu Gly Ile 
                325                 330                 335     


Phe Ile Ser Phe Ile Leu Ala Gly Gly Pro Ala Asp Leu Ser Gly Glu 
            340                 345                 350         


Leu Arg Lys Gly Asp Gln Ile Leu Ser Val Asn Gly Val Asp Leu Arg 
        355                 360                 365             


Asn Ala Ser His Glu Gln Ala Ala Ile Ala Leu Lys Asn Ala Gly Gln 
    370                 375                 380                 


Thr Val Thr Ile Ile Ala Gln Tyr Lys Pro Glu Glu Tyr Ser Arg Phe 
385                 390                 395                 400 


Glu Ala Lys Ile His Asp Leu Arg Glu Gln Leu Met Asn Ser Ser Leu 
                405                 410                 415     


Gly Ser Gly Thr Ala Ser Leu Arg Ser Asn Pro Lys Arg Gly Phe Tyr 
            420                 425                 430         


Ile Arg Ala Leu Phe Asp Tyr Asp Lys Thr Lys Asp Cys Gly Phe Leu 
        435                 440                 445             


Ser Gln Ala Leu Ser Phe Arg Phe Gly Asp Val Leu His Val Ile Asp 
    450                 455                 460                 


Ala Ser Asp Glu Glu Trp Trp Gln Ala Arg Arg Val His Ser Asp Ser 
465                 470                 475                 480 


Glu Thr Asp Asp Ile Gly Phe Ile Pro Ser Lys Arg Arg Val Glu Arg 
                485                 490                 495     


Arg Glu Trp Ser Arg Leu Lys Ala Lys Asp Trp Gly Ser Ser Ser Gly 
            500                 505                 510         


Ser Gln Gly Arg Glu Asp Ser Val Leu Ser Tyr Glu Thr Val Thr Gln 
        515                 520                 525             


Met Glu Val His Tyr Ala Arg Pro Ile Ile Ile Leu Gly Pro Thr Lys 
    530                 535                 540                 


Asp Arg Ala Asn Asp Asp Leu Leu Ser Glu Phe Pro Asp Lys Phe Gly 
545                 550                 555                 560 


Ser Cys Val Pro His Thr Thr Arg Pro Lys Arg Glu Tyr Glu Ile Asp 
                565                 570                 575     


Gly Arg Asp Tyr His Phe Val Ser Ser Arg Glu Lys Met Glu Lys Asp 
            580                 585                 590         


Ile Gln Ala His Lys Phe Ile Glu Ala Gly Gln Tyr Asn Ser His Leu 
        595                 600                 605             


Tyr Gly Thr Ser Val Gln Ser Val Arg Glu Val Ala Glu Gln Gly Lys 
    610                 615                 620                 


His Cys Ile Leu Asp Val Ser Ala Asn Ala Val Arg Arg Leu Gln Ala 
625                 630                 635                 640 


Ala His Leu His Pro Ile Ala Ile Phe Ile Arg Pro Arg Ser Leu Glu 
                645                 650                 655     


Asn Val Leu Glu Ile Asn Lys Arg Ile Thr Glu Glu Gln Ala Arg Lys 
            660                 665                 670         


Ala Phe Asp Arg Ala Thr Lys Leu Glu Gln Glu Phe Thr Glu Cys Phe 
        675                 680                 685             


Ser Ala Ile Val Glu Gly Asp Ser Phe Glu Glu Ile Tyr His Lys Val 
    690                 695                 700                 


Lys Arg Val Ile Glu Asp Leu Ser Gly Pro Tyr Ile Trp Val Pro Ala 
705                 710                 715                 720 


Arg Glu Arg Leu 
                


<210>  4266
<211>  721
<212>  PRT
<213>  Homo Sapiens

<400>  4266

Met Asp Cys Leu Cys Ile Val Thr Thr Lys Lys Tyr Arg Tyr Gln Asp 
1               5                   10                  15      


Glu Asp Thr Pro Pro Leu Glu His Ser Pro Ala His Leu Pro Asn Gln 
            20                  25                  30          


Ala Asn Ser Pro Pro Val Ile Val Asn Thr Asp Thr Leu Glu Ala Pro 
        35                  40                  45              


Gly Tyr Val Asn Gly Thr Glu Gly Glu Met Glu Tyr Glu Glu Ile Thr 
    50                  55                  60                  


Leu Glu Arg Gly Asn Ser Gly Leu Gly Phe Ser Ile Ala Gly Gly Thr 
65                  70                  75                  80  


Asp Asn Pro His Ile Gly Asp Asp Pro Ser Ile Phe Ile Thr Lys Ile 
                85                  90                  95      


Ile Pro Gly Gly Ala Ala Ala Gln Asp Gly Arg Leu Arg Val Asn Asp 
            100                 105                 110         


Ser Ile Leu Phe Val Asn Glu Val Asp Val Arg Glu Val Thr His Ser 
        115                 120                 125             


Ala Ala Val Glu Ala Leu Lys Glu Ala Gly Ser Ile Val Arg Leu Tyr 
    130                 135                 140                 


Val Met Arg Arg Lys Pro Pro Ala Glu Lys Val Met Glu Ile Lys Leu 
145                 150                 155                 160 


Ile Lys Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala Gly Gly Val Gly 
                165                 170                 175     


Asn Gln His Ile Pro Gly Asp Asn Ser Ile Tyr Val Thr Lys Ile Ile 
            180                 185                 190         


Glu Gly Gly Ala Ala His Lys Asp Gly Arg Leu Gln Ile Gly Asp Lys 
        195                 200                 205             


Ile Leu Ala Val Asn Ser Val Gly Leu Glu Asp Val Met His Glu Asp 
    210                 215                 220                 


Ala Val Ala Ala Leu Lys Asn Thr Tyr Asp Val Val Tyr Leu Lys Val 
225                 230                 235                 240 


Ala Lys Pro Ser Asn Ala Tyr Leu Ser Asp Ser Tyr Ala Pro Pro Asp 
                245                 250                 255     


Ile Thr Thr Ser Tyr Ser Gln His Leu Asp Asn Glu Ile Ser His Ser 
            260                 265                 270         


Ser Tyr Leu Gly Thr Asp Tyr Pro Thr Ala Met Thr Pro Thr Ser Pro 
        275                 280                 285             


Arg Arg Tyr Ser Pro Val Ala Lys Asp Leu Leu Gly Glu Glu Asp Ile 
    290                 295                 300                 


Pro Arg Glu Pro Arg Arg Ile Val Ile His Arg Gly Ser Thr Gly Leu 
305                 310                 315                 320 


Gly Phe Asn Ile Val Gly Gly Glu Asp Gly Glu Gly Ile Phe Ile Ser 
                325                 330                 335     


Phe Ile Leu Ala Gly Gly Pro Ala Asp Leu Ser Gly Glu Leu Arg Lys 
            340                 345                 350         


Gly Asp Gln Ile Leu Ser Val Asn Gly Val Asp Leu Arg Asn Ala Ser 
        355                 360                 365             


His Glu Gln Ala Ala Ile Ala Leu Lys Asn Ala Gly Gln Thr Val Thr 
    370                 375                 380                 


Ile Ile Ala Gln Tyr Lys Pro Glu Glu Tyr Ser Arg Phe Glu Ala Lys 
385                 390                 395                 400 


Ile His Asp Leu Arg Glu Gln Leu Met Asn Ser Ser Leu Gly Ser Gly 
                405                 410                 415     


Thr Ala Ser Leu Arg Ser Asn Pro Lys Arg Gly Phe Tyr Ile Arg Ala 
            420                 425                 430         


Leu Phe Asp Tyr Asp Lys Thr Lys Asp Cys Gly Phe Leu Ser Gln Ala 
        435                 440                 445             


Leu Ser Phe Arg Phe Gly Asp Val Leu His Val Ile Asp Ala Ser Asp 
    450                 455                 460                 


Glu Glu Trp Trp Gln Ala Arg Arg Val His Ser Asp Ser Glu Thr Asp 
465                 470                 475                 480 


Asp Ile Gly Phe Ile Pro Ser Lys Arg Arg Val Glu Arg Arg Glu Trp 
                485                 490                 495     


Ser Arg Leu Lys Ala Lys Asp Trp Gly Ser Ser Ser Gly Ser Gln Gly 
            500                 505                 510         


Arg Glu Asp Ser Val Leu Ser Tyr Glu Thr Val Thr Gln Met Glu Val 
        515                 520                 525             


His Tyr Ala Arg Pro Ile Ile Ile Leu Gly Pro Thr Lys Asp Arg Ala 
    530                 535                 540                 


Asn Asp Asp Leu Leu Ser Glu Phe Pro Asp Lys Phe Gly Ser Cys Val 
545                 550                 555                 560 


Pro His Thr Thr Arg Pro Lys Arg Glu Tyr Glu Ile Asp Gly Arg Asp 
                565                 570                 575     


Tyr His Phe Val Ser Ser Arg Glu Lys Met Glu Lys Asp Ile Gln Ala 
            580                 585                 590         


His Lys Phe Ile Glu Ala Gly Gln Tyr Asn Ser His Leu Tyr Gly Thr 
        595                 600                 605             


Ser Val Gln Ser Val Arg Glu Val Ala Glu Gln Gly Lys His Cys Ile 
    610                 615                 620                 


Leu Asp Val Ser Ala Asn Ala Val Arg Arg Leu Gln Ala Ala His Leu 
625                 630                 635                 640 


His Pro Ile Ala Ile Phe Ile Arg Pro Arg Ser Leu Glu Asn Val Leu 
                645                 650                 655     


Glu Ile Asn Lys Arg Ile Thr Glu Glu Gln Ala Arg Lys Ala Phe Asp 
            660                 665                 670         


Arg Ala Thr Lys Leu Glu Gln Glu Phe Thr Glu Cys Phe Ser Ala Ile 
        675                 680                 685             


Val Glu Gly Asp Ser Phe Glu Glu Ile Tyr His Lys Val Lys Arg Val 
    690                 695                 700                 


Ile Glu Asp Leu Ser Gly Pro Tyr Ile Trp Val Pro Ala Arg Glu Arg 
705                 710                 715                 720 


Leu 
    


<210>  4267
<211>  296
<212>  PRT
<213>  Homo Sapiens

<400>  4267

Met Asp Cys Leu Cys Ile Val Thr Thr Lys Lys Tyr Arg Tyr Gln Asp 
1               5                   10                  15      


Glu Asp Thr Pro Pro Leu Glu His Ser Pro Ala His Leu Pro Asn Gln 
            20                  25                  30          


Ala Asn Ser Pro Pro Val Ile Val Asn Thr Asp Thr Leu Glu Ala Pro 
        35                  40                  45              


Gly Tyr Val Asn Gly Thr Glu Gly Glu Met Glu Tyr Glu Glu Ile Thr 
    50                  55                  60                  


Leu Glu Arg Gly Asn Ser Gly Leu Gly Phe Ser Ile Ala Gly Gly Thr 
65                  70                  75                  80  


Asp Asn Pro His Ile Gly Asp Asp Pro Ser Ile Phe Ile Thr Lys Ile 
                85                  90                  95      


Ile Pro Gly Gly Ala Ala Ala Gln Asp Gly Arg Leu Arg Val Asn Asp 
            100                 105                 110         


Ser Ile Leu Phe Val Asn Glu Val Asp Val Arg Glu Val Thr His Ser 
        115                 120                 125             


Ala Ala Val Glu Ala Leu Lys Glu Ala Gly Ser Ile Val Arg Leu Tyr 
    130                 135                 140                 


Val Met Arg Arg Lys Pro Pro Ala Glu Lys Val Met Glu Ile Lys Leu 
145                 150                 155                 160 


Ile Lys Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala Gly Gly Val Gly 
                165                 170                 175     


Asn Gln His Ile Pro Gly Asp Asn Ser Ile Tyr Val Thr Lys Ile Ile 
            180                 185                 190         


Glu Gly Gly Ala Ala His Lys Asp Gly Arg Leu Gln Ile Gly Asp Lys 
        195                 200                 205             


Ile Leu Ala Val Asn Ser Val Gly Leu Glu Asp Val Met His Glu Asp 
    210                 215                 220                 


Ala Val Ala Ala Leu Lys Asn Thr Tyr Asp Val Val Tyr Leu Lys Val 
225                 230                 235                 240 


Ala Lys Pro Ser Asn Ala Tyr Leu Ser Asp Ser Tyr Ala Pro Pro Asp 
                245                 250                 255     


Ile Thr Thr Cys Glu Ser Pro Ser Asn Thr Lys Val Pro His Asp Pro 
            260                 265                 270         


Ser Arg Leu Thr His Asp Met Gln Ser His Asp Ile Pro Val Ala Val 
        275                 280                 285             


Pro Leu Gln Ile Phe Pro Met Lys 
    290                 295     


<210>  4268
<211>  234
<212>  PRT
<213>  Homo Sapiens

<400>  4268

Met Asp Cys Leu Cys Ile Val Thr Thr Lys Lys Tyr Arg Tyr Gln Asp 
1               5                   10                  15      


Glu Asp Thr Pro Pro Leu Glu His Ser Pro Ala His Leu Pro Asn Gln 
            20                  25                  30          


Val Asn Ala Pro Glu Leu Val His Val Ala Glu Arg Asn Leu Ser His 
        35                  40                  45              


Leu Glu Ala Gly His Gly Val Val Gly His Ala His Leu Ser Pro Phe 
    50                  55                  60                  


Lys Ala Asn Ser Pro Pro Val Ile Val Asn Thr Asp Thr Leu Glu Ala 
65                  70                  75                  80  


Pro Gly Tyr Val Asn Gly Thr Glu Gly Glu Met Glu Tyr Glu Glu Ile 
                85                  90                  95      


Thr Leu Glu Arg Gly Asn Ser Gly Leu Gly Phe Ser Ile Ala Gly Gly 
            100                 105                 110         


Thr Asp Asn Pro His Ile Gly Asp Asp Pro Ser Ile Phe Ile Thr Lys 
        115                 120                 125             


Ile Ile Pro Gly Gly Ala Ala Ala Gln Asp Gly Arg Leu Arg Val Asn 
    130                 135                 140                 


Asp Ser Ile Leu Phe Val Asn Glu Val Asp Val Arg Glu Val Thr His 
145                 150                 155                 160 


Ser Ala Ala Val Glu Ala Leu Lys Glu Ala Gly Ser Ile Val Arg Leu 
                165                 170                 175     


Tyr Val Met Arg Arg Lys Pro Pro Ala Glu Lys Val Met Glu Ile Lys 
            180                 185                 190         


Leu Ile Lys Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala Gly Gly Val 
        195                 200                 205             


Gly Asn Gln His Ile Pro Gly Asp Asn Ser Ile Tyr Val Thr Lys Ile 
    210                 215                 220                 


Ile Glu Gly Gly Ala Ala His Lys Asp Gly 
225                 230                 


<210>  4269
<211>  91
<212>  PRT
<213>  Homo Sapiens

<400>  4269

Met Glu Tyr Glu Glu Ile Thr Leu Glu Arg Gly Asn Ser Gly Leu Gly 
1               5                   10                  15      


Phe Ser Ile Ala Gly Gly Thr Asp Asn Pro His Ile Gly Asp Asp Pro 
            20                  25                  30          


Ser Ile Phe Ile Thr Lys Ile Ile Pro Gly Gly Ala Ala Ala Gln Asp 
        35                  40                  45              


Gly Arg Leu Arg Val Asn Asp Ser Ile Leu Phe Val Asn Glu Val Asp 
    50                  55                  60                  


Val Arg Glu Val Thr His Ser Ala Ala Val Glu Ala Leu Lys Glu Ala 
65                  70                  75                  80  


Gly Ser Ile Val Arg Leu Tyr Val Met Arg Arg 
                85                  90      


<210>  4270
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  4270

Met Glu Tyr Glu Glu Ile Thr Leu Glu Arg Gly Asn Ser Gly Leu Gly 
1               5                   10                  15      


Phe Ser Ile Ala Gly Gly Thr Asp Asn Pro His Ile Gly Asp Asp Pro 
            20                  25                  30          


Ser Ile Phe Ile Thr Lys Ile Ile Pro Gly Gly Ala Ala Ala Gln Asp 
        35                  40                  45              


Gly Arg Leu Arg Val Asn Asp Ser Ile Leu Phe Val Asn Glu Val Asp 
    50                  55                  60                  


Val Arg Glu Val Thr His Ser Ala Ala Val Glu Ala Leu Lys Glu Ala 
65                  70                  75                  80  


Gly Ser Ile Val Arg Leu Tyr Val Met Arg Arg Lys Pro Pro Ala Glu 
                85                  90                  95      


Lys Val Met Glu Ile Lys Leu Ile Lys Gly Pro Lys Gly Leu Gly Phe 
            100                 105                 110         


Ser Ile Ala Gly 
        115     


<210>  4271
<211>  281
<212>  PRT
<213>  Homo Sapiens

<400>  4271

Met Pro Ile Asn Gly Val Asn Leu Ala Trp Lys Tyr Arg Tyr Gln Asp 
1               5                   10                  15      


Glu Asp Thr Pro Pro Leu Glu His Ser Pro Ala His Leu Pro Asn Gln 
            20                  25                  30          


Val Asn Ala Pro Glu Leu Val His Val Ala Glu Arg Asn Leu Ser His 
        35                  40                  45              


Leu Glu Ala Gly His Gly Val Val Gly His Ala His Leu Ser Pro Phe 
    50                  55                  60                  


Lys Ala Asn Ser Pro Pro Val Ile Val Asn Thr Asp Thr Leu Glu Ala 
65                  70                  75                  80  


Pro Gly Tyr Glu Leu Gln Val Asn Gly Thr Glu Gly Glu Met Glu Tyr 
                85                  90                  95      


Glu Glu Ile Thr Leu Glu Arg Gly Asn Ser Gly Leu Gly Phe Ser Ile 
            100                 105                 110         


Ala Gly Gly Thr Asp Asn Pro His Ile Gly Asp Asp Pro Ser Ile Phe 
        115                 120                 125             


Ile Thr Lys Ile Ile Pro Gly Gly Ala Ala Ala Gln Asp Gly Arg Leu 
    130                 135                 140                 


Arg Val Asn Asp Ser Ile Leu Phe Val Asn Glu Val Asp Val Arg Glu 
145                 150                 155                 160 


Val Thr His Ser Ala Ala Val Glu Ala Leu Lys Glu Ala Gly Ser Ile 
                165                 170                 175     


Val Arg Leu Tyr Val Met Arg Arg Lys Pro Pro Ala Glu Lys Val Met 
            180                 185                 190         


Glu Ile Lys Leu Ile Lys Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala 
        195                 200                 205             


Gly Gly Val Gly Asn Gln His Ile Pro Gly Asp Asn Ser Ile Tyr Val 
    210                 215                 220                 


Thr Lys Ile Ile Glu Gly Gly Ala Ala His Lys Asp Gly Arg Leu Gln 
225                 230                 235                 240 


Ile Gly Asp Lys Ile Leu Ala Val Asn Ser Val Gly Leu Glu Asp Val 
                245                 250                 255     


Met His Glu Asp Ala Val Ala Ala Leu Lys Asn Thr Tyr Asp Val Val 
            260                 265                 270         


Tyr Leu Lys Val Ala Lys Pro Ser Asn 
        275                 280     


<210>  4272
<211>  767
<212>  PRT
<213>  Homo Sapiens

<400>  4272

Met Ser Gln Arg Pro Arg Ala Pro Arg Ser Ala Leu Trp Leu Leu Ala 
1               5                   10                  15      


Pro Pro Leu Leu Arg Trp Ala Pro Pro Leu Leu Thr Val Leu His Ser 
            20                  25                  30          


Asp Leu Phe Gln Ala Leu Leu Asp Ile Leu Asp Tyr Tyr Glu Ala Ser 
        35                  40                  45              


Leu Ser Glu Ser Gln Lys Tyr Arg Tyr Gln Asp Glu Asp Thr Pro Pro 
    50                  55                  60                  


Leu Glu His Ser Pro Ala His Leu Pro Asn Gln Ala Asn Ser Pro Pro 
65                  70                  75                  80  


Val Ile Val Asn Thr Asp Thr Leu Glu Ala Pro Gly Tyr Glu Leu Gln 
                85                  90                  95      


Val Asn Gly Thr Glu Gly Glu Met Glu Tyr Glu Glu Ile Thr Leu Glu 
            100                 105                 110         


Arg Gly Asn Ser Gly Leu Gly Phe Ser Ile Ala Gly Gly Thr Asp Asn 
        115                 120                 125             


Pro His Ile Gly Asp Asp Pro Ser Ile Phe Ile Thr Lys Ile Ile Pro 
    130                 135                 140                 


Gly Gly Ala Ala Ala Gln Asp Gly Arg Leu Arg Val Asn Asp Ser Ile 
145                 150                 155                 160 


Leu Phe Val Asn Glu Val Asp Val Arg Glu Val Thr His Ser Ala Ala 
                165                 170                 175     


Val Glu Ala Leu Lys Glu Ala Gly Ser Ile Val Arg Leu Tyr Val Met 
            180                 185                 190         


Arg Arg Lys Pro Pro Ala Glu Lys Val Met Glu Ile Lys Leu Ile Lys 
        195                 200                 205             


Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala Gly Gly Val Gly Asn Gln 
    210                 215                 220                 


His Ile Pro Gly Asp Asn Ser Ile Tyr Val Thr Lys Ile Ile Glu Gly 
225                 230                 235                 240 


Gly Ala Ala His Lys Asp Gly Arg Leu Gln Ile Gly Asp Lys Ile Leu 
                245                 250                 255     


Ala Val Asn Ser Val Gly Leu Glu Asp Val Met His Glu Asp Ala Val 
            260                 265                 270         


Ala Ala Leu Lys Asn Thr Tyr Asp Val Val Tyr Leu Lys Val Ala Lys 
        275                 280                 285             


Pro Ser Asn Ala Tyr Leu Ser Asp Ser Tyr Ala Pro Pro Asp Ile Thr 
    290                 295                 300                 


Thr Ser Tyr Ser Gln His Leu Asp Asn Glu Ile Ser His Ser Ser Tyr 
305                 310                 315                 320 


Leu Gly Thr Asp Tyr Pro Thr Ala Met Thr Pro Thr Ser Pro Arg Arg 
                325                 330                 335     


Tyr Ser Pro Val Ala Lys Asp Leu Leu Gly Glu Glu Asp Ile Pro Arg 
            340                 345                 350         


Glu Pro Arg Arg Ile Val Ile His Arg Gly Ser Thr Gly Leu Gly Phe 
        355                 360                 365             


Asn Ile Val Gly Gly Glu Asp Gly Glu Gly Ile Phe Ile Ser Phe Ile 
    370                 375                 380                 


Leu Ala Gly Gly Pro Ala Asp Leu Ser Gly Glu Leu Arg Lys Gly Asp 
385                 390                 395                 400 


Gln Ile Leu Ser Val Asn Gly Val Asp Leu Arg Asn Ala Ser His Glu 
                405                 410                 415     


Gln Ala Ala Ile Ala Leu Lys Asn Ala Gly Gln Thr Val Thr Ile Ile 
            420                 425                 430         


Ala Gln Tyr Lys Pro Glu Glu Tyr Ser Arg Phe Glu Ala Lys Ile His 
        435                 440                 445             


Asp Leu Arg Glu Gln Leu Met Asn Ser Ser Leu Gly Ser Gly Thr Ala 
    450                 455                 460                 


Ser Leu Arg Ser Asn Pro Lys Arg Gly Phe Tyr Ile Arg Ala Leu Phe 
465                 470                 475                 480 


Asp Tyr Asp Lys Thr Lys Asp Cys Gly Phe Leu Ser Gln Ala Leu Ser 
                485                 490                 495     


Phe Arg Phe Gly Asp Val Leu His Val Ile Asp Ala Ser Asp Glu Glu 
            500                 505                 510         


Trp Trp Gln Ala Arg Arg Val His Ser Asp Ser Glu Thr Asp Asp Ile 
        515                 520                 525             


Gly Phe Ile Pro Ser Lys Arg Arg Val Glu Arg Arg Glu Trp Ser Arg 
    530                 535                 540                 


Leu Lys Ala Lys Asp Trp Gly Ser Ser Ser Gly Ser Gln Gly Arg Glu 
545                 550                 555                 560 


Asp Ser Val Leu Ser Tyr Glu Thr Val Thr Gln Met Glu Val His Tyr 
                565                 570                 575     


Ala Arg Pro Ile Ile Ile Leu Gly Pro Thr Lys Asp Arg Ala Asn Asp 
            580                 585                 590         


Asp Leu Leu Ser Glu Phe Pro Asp Lys Phe Gly Ser Cys Val Pro His 
        595                 600                 605             


Thr Thr Arg Pro Lys Arg Glu Tyr Glu Ile Asp Gly Arg Asp Tyr His 
    610                 615                 620                 


Phe Val Ser Ser Arg Glu Lys Met Glu Lys Asp Ile Gln Ala His Lys 
625                 630                 635                 640 


Phe Ile Glu Ala Gly Gln Tyr Asn Ser His Leu Tyr Gly Thr Ser Val 
                645                 650                 655     


Gln Ser Val Arg Glu Val Ala Glu Gln Gly Lys His Cys Ile Leu Asp 
            660                 665                 670         


Val Ser Ala Asn Ala Val Arg Arg Leu Gln Ala Ala His Leu His Pro 
        675                 680                 685             


Ile Ala Ile Phe Ile Arg Pro Arg Ser Leu Glu Asn Val Leu Glu Ile 
    690                 695                 700                 


Asn Lys Arg Ile Thr Glu Glu Gln Ala Arg Lys Ala Phe Asp Arg Ala 
705                 710                 715                 720 


Thr Lys Leu Glu Gln Glu Phe Thr Glu Cys Phe Ser Ala Ile Val Glu 
                725                 730                 735     


Gly Asp Ser Phe Glu Glu Ile Tyr His Lys Val Lys Arg Val Ile Glu 
            740                 745                 750         


Asp Leu Ser Gly Pro Tyr Ile Trp Val Pro Ala Arg Glu Arg Leu 
        755                 760                 765         


<210>  4273
<211>  85
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4273

Xaa Gly Pro Thr Lys Asp Arg Ala Asn Asp Asp Leu Leu Ser Glu Phe 
1               5                   10                  15      


Pro Asp Lys Phe Gly Ser Cys Val Pro His Thr Thr Arg Pro Lys Arg 
            20                  25                  30          


Glu Tyr Glu Ile Asp Gly Arg Asp Tyr His Phe Val Ser Ser Arg Glu 
        35                  40                  45              


Lys Met Glu Lys Asp Ile Gln Ala His Lys Phe Ile Glu Ala Gly Gln 
    50                  55                  60                  


Tyr Asn Ser His Leu Tyr Gly Thr Ser Val Gln Ser Val Arg Glu Val 
65                  70                  75                  80  


Ala Glu Gln Arg Asp 
                85  


<210>  4274
<211>  97
<212>  PRT
<213>  Homo Sapiens

<400>  4274

Met Thr Ala Thr Glu Ala Leu Leu Arg Val Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Phe Gly His Ser Thr Tyr Gly Ala Glu Cys Phe Pro Ala Cys Asn Pro 
            20                  25                  30          


Gln Asn Gly Phe Cys Glu Asp Asp Asn Val Cys Arg Cys Gln Pro Gly 
        35                  40                  45              


Trp Gln Gly Pro Leu Cys Asp Gln Cys Val Thr Ser Pro Gly Cys Leu 
    50                  55                  60                  


His Gly Leu Cys Gly Glu Pro Gly Gln Cys Ile Cys Thr Asp Gly Trp 
65                  70                  75                  80  


Asp Gly Glu Leu Cys Asp Arg Asp Val Arg Ala Cys Ser Ser Ala Pro 
                85                  90                  95      


Cys 
    


<210>  4275
<211>  310
<212>  PRT
<213>  Homo Sapiens

<400>  4275

Met Thr Ala Thr Glu Ala Leu Leu Arg Val Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Phe Gly His Ser Thr Tyr Gly Ala Glu Cys Phe Pro Ala Cys Asn Pro 
            20                  25                  30          


Gln Asn Gly Phe Cys Glu Asp Asp Asn Val Cys Arg Cys Gln Pro Gly 
        35                  40                  45              


Trp Gln Gly Pro Leu Cys Asp Gln Cys Val Thr Ser Pro Gly Cys Leu 
    50                  55                  60                  


His Gly Leu Cys Gly Glu Pro Gly Gln Cys Ile Cys Thr Asp Gly Trp 
65                  70                  75                  80  


Asp Gly Glu Leu Cys Asp Arg Asp Val Arg Ala Cys Ser Ser Ala Pro 
                85                  90                  95      


Cys Ala Asn Asn Arg Thr Cys Val Ser Leu Asp Asp Gly Leu Tyr Glu 
            100                 105                 110         


Cys Ser Cys Ala Pro Gly Tyr Ser Gly Lys Asp Cys Gln Lys Lys Asp 
        115                 120                 125             


Gly Pro Cys Val Ile Asn Gly Ser Pro Cys Gln His Gly Gly Thr Cys 
    130                 135                 140                 


Val Asp Asp Glu Gly Arg Ala Ser His Ala Ser Cys Leu Cys Pro Pro 
145                 150                 155                 160 


Gly Phe Ser Gly Asn Phe Cys Glu Ile Val Ala Asn Ser Cys Thr Pro 
                165                 170                 175     


Asn Pro Cys Glu Asn Asp Gly Val Cys Thr Asp Ile Gly Gly Asp Phe 
            180                 185                 190         


Arg Cys Arg Cys Pro Ala Gly Phe Ile Asp Lys Thr Cys Ser Arg Pro 
        195                 200                 205             


Val Thr Asn Cys Ala Ser Ser Pro Cys Gln Asn Gly Gly Thr Cys Leu 
    210                 215                 220                 


Gln His Thr Gln Gly Gln Ala Ile Cys Phe Thr Ile Leu Gly Val Leu 
225                 230                 235                 240 


Thr Ser Leu Val Val Leu Gly Thr Val Gly Ile Val Phe Leu Asn Lys 
                245                 250                 255     


Cys Glu Thr Trp Val Ser Asn Leu Arg Tyr Asn His Met Leu Arg Lys 
            260                 265                 270         


Lys Lys Asn Leu Leu Leu Gln Tyr Asn Ser Gly Glu Asp Leu Ala Val 
        275                 280                 285             


Asn Ile Ile Phe Pro Glu Lys Ile Asp Met Thr Thr Phe Ser Lys Glu 
    290                 295                 300                 


Ala Gly Asp Glu Glu Ile 
305                 310 


<210>  4276
<211>  383
<212>  PRT
<213>  Homo Sapiens

<400>  4276

Met Thr Ala Thr Glu Ala Leu Leu Arg Val Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Phe Gly His Ser Thr Tyr Gly Ala Glu Cys Phe Pro Ala Cys Asn Pro 
            20                  25                  30          


Gln Asn Gly Phe Cys Glu Asp Asp Asn Val Cys Arg Cys Gln Pro Gly 
        35                  40                  45              


Trp Gln Gly Pro Leu Cys Asp Gln Cys Val Thr Ser Pro Gly Cys Leu 
    50                  55                  60                  


His Gly Leu Cys Gly Glu Pro Gly Gln Cys Ile Cys Thr Asp Gly Trp 
65                  70                  75                  80  


Asp Gly Glu Leu Cys Asp Arg Asp Val Arg Ala Cys Ser Ser Ala Pro 
                85                  90                  95      


Cys Ala Asn Asn Arg Thr Cys Val Ser Leu Asp Asp Gly Leu Tyr Glu 
            100                 105                 110         


Cys Ser Cys Ala Pro Gly Tyr Ser Gly Lys Asp Cys Gln Lys Lys Asp 
        115                 120                 125             


Gly Pro Cys Val Ile Asn Gly Ser Pro Cys Gln His Gly Gly Thr Cys 
    130                 135                 140                 


Val Asp Asp Glu Gly Arg Ala Ser His Ala Ser Cys Leu Cys Pro Pro 
145                 150                 155                 160 


Gly Phe Ser Gly Asn Phe Cys Glu Ile Val Ala Asn Ser Cys Thr Pro 
                165                 170                 175     


Asn Pro Cys Glu Asn Asp Gly Val Cys Thr Asp Ile Gly Gly Asp Phe 
            180                 185                 190         


Arg Cys Arg Cys Pro Ala Gly Phe Ile Asp Lys Thr Cys Ser Arg Pro 
        195                 200                 205             


Val Thr Asn Cys Ala Ser Ser Pro Cys Gln Asn Gly Gly Thr Cys Leu 
    210                 215                 220                 


Gln His Thr Gln Val Ser Tyr Glu Cys Leu Cys Lys Pro Glu Phe Thr 
225                 230                 235                 240 


Gly Leu Thr Cys Val Lys Lys Arg Ala Leu Ser Pro Gln Gln Val Thr 
                245                 250                 255     


Arg Leu Pro Ser Gly Tyr Gly Leu Ala Tyr Arg Leu Thr Pro Gly Val 
            260                 265                 270         


His Glu Leu Pro Val Gln Gln Pro Glu His Arg Ile Leu Lys Val Ser 
        275                 280                 285             


Met Lys Glu Leu Asn Lys Lys Thr Pro Leu Leu Thr Glu Gly Gln Ala 
    290                 295                 300                 


Ile Cys Phe Thr Ile Leu Gly Val Leu Thr Ser Leu Val Val Leu Gly 
305                 310                 315                 320 


Thr Val Gly Ile Val Phe Leu Asn Lys Cys Glu Thr Trp Val Ser Asn 
                325                 330                 335     


Leu Arg Tyr Asn His Met Leu Arg Lys Lys Lys Asn Leu Leu Leu Gln 
            340                 345                 350         


Tyr Asn Ser Gly Glu Asp Leu Ala Val Asn Ile Ile Phe Pro Glu Lys 
        355                 360                 365             


Ile Asp Met Thr Thr Phe Ser Lys Glu Ala Gly Asp Glu Glu Ile 
    370                 375                 380             


<210>  4277
<211>  136
<212>  PRT
<213>  Homo Sapiens

<400>  4277

Met Thr Ala Thr Glu Ala Leu Leu Arg Val Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Phe Gly His Ser Thr Tyr Gly Ala Glu Cys Phe Pro Ala Cys Asn Pro 
            20                  25                  30          


Gln Asn Gly Phe Cys Glu Asp Asp Asn Val Cys Arg Cys Gln Pro Gly 
        35                  40                  45              


Trp Gln Gly Pro Leu Cys Asp Gln Cys Val Thr Ser Pro Gly Cys Leu 
    50                  55                  60                  


His Gly Leu Cys Gly Glu Pro Gly Gln Cys Ile Cys Thr Asp Gly Trp 
65                  70                  75                  80  


Asp Gly Glu Leu Cys Asp Arg Gly Trp His Ser Pro Leu Phe Thr Ser 
                85                  90                  95      


Ala Leu Arg Pro Tyr Leu Pro Ala Leu Ala Pro Thr Thr Ser Ser Gln 
            100                 105                 110         


Ser Pro Val Ala Gly Val Pro His Phe Leu Ile Pro Ala His Ser Val 
        115                 120                 125             


Pro Cys Ile Leu Lys Ile Cys Leu 
    130                 135     


<210>  4278
<211>  54
<212>  PRT
<213>  Homo Sapiens

<400>  4278

Met Gly Ser Arg Cys Ala Leu Ala Leu Ala Val Leu Ser Ala Leu Leu 
1               5                   10                  15      


Cys Gln Val Trp Ser Ser Gly Val Phe Glu Leu Lys Leu Gln Glu Phe 
            20                  25                  30          


Val Asn Lys Lys Gly Leu Leu Gly Asn Arg Asn Cys Cys Arg Gly Gly 
        35                  40                  45              


Ala Gly Pro Pro Pro Cys 
    50                  


<210>  4279
<211>  723
<212>  PRT
<213>  Homo Sapiens

<400>  4279

Met Gly Ser Arg Cys Ala Leu Ala Leu Ala Val Leu Ser Ala Leu Leu 
1               5                   10                  15      


Cys Gln Val Trp Ser Ser Gly Val Phe Glu Leu Lys Leu Gln Glu Phe 
            20                  25                  30          


Val Asn Lys Lys Gly Leu Leu Gly Asn Arg Asn Cys Cys Arg Gly Gly 
        35                  40                  45              


Ala Gly Pro Pro Pro Cys Ala Cys Arg Thr Phe Phe Arg Val Cys Leu 
    50                  55                  60                  


Lys His Tyr Gln Ala Ser Val Ser Pro Glu Pro Pro Cys Thr Tyr Gly 
65                  70                  75                  80  


Ser Ala Val Thr Pro Val Leu Gly Val Asp Ser Phe Ser Leu Pro Asp 
                85                  90                  95      


Gly Gly Gly Ala Asp Ser Ala Phe Ser Asn Pro Ile Arg Phe Pro Phe 
            100                 105                 110         


Gly Phe Thr Trp Pro Gly Thr Phe Ser Leu Ile Ile Glu Ala Leu His 
        115                 120                 125             


Thr Asp Ser Pro Asp Asp Leu Ala Thr Glu Asn Pro Glu Arg Leu Ile 
    130                 135                 140                 


Ser Arg Leu Ala Thr Gln Arg His Leu Thr Val Gly Glu Glu Trp Ser 
145                 150                 155                 160 


Gln Asp Leu His Ser Ser Gly Arg Thr Asp Leu Lys Tyr Ser Tyr Arg 
                165                 170                 175     


Phe Val Cys Asp Glu His Tyr Tyr Gly Glu Gly Cys Ser Val Phe Cys 
            180                 185                 190         


Arg Pro Arg Asp Asp Ala Phe Gly His Phe Thr Cys Gly Glu Arg Gly 
        195                 200                 205             


Glu Lys Val Cys Asn Pro Gly Trp Lys Gly Pro Tyr Cys Thr Glu Pro 
    210                 215                 220                 


Ile Cys Leu Pro Gly Cys Asp Glu Gln His Gly Phe Cys Asp Lys Pro 
225                 230                 235                 240 


Gly Glu Cys Lys Cys Arg Val Gly Trp Gln Gly Arg Tyr Cys Asp Glu 
                245                 250                 255     


Cys Ile Arg Tyr Pro Gly Cys Leu His Gly Thr Cys Gln Gln Pro Trp 
            260                 265                 270         


Gln Cys Asn Cys Gln Glu Gly Trp Gly Gly Leu Phe Cys Asn Gln Asp 
        275                 280                 285             


Leu Asn Tyr Cys Thr His His Lys Pro Cys Lys Asn Gly Ala Thr Cys 
    290                 295                 300                 


Thr Asn Thr Gly Gln Gly Ser Tyr Thr Cys Ser Cys Arg Pro Gly Tyr 
305                 310                 315                 320 


Thr Gly Ala Thr Cys Glu Leu Gly Ile Asp Glu Cys Asp Pro Ser Pro 
                325                 330                 335     


Cys Lys Asn Gly Gly Ser Cys Thr Asp Leu Glu Asn Ser Tyr Ser Cys 
            340                 345                 350         


Thr Cys Pro Pro Gly Phe Tyr Gly Lys Ile Cys Glu Leu Ser Ala Met 
        355                 360                 365             


Thr Cys Ala Asp Gly Pro Cys Phe Asn Gly Gly Arg Cys Ser Asp Ser 
    370                 375                 380                 


Pro Asp Gly Gly Tyr Ser Cys Arg Cys Pro Val Gly Tyr Ser Gly Phe 
385                 390                 395                 400 


Asn Cys Glu Lys Lys Ile Asp Tyr Cys Ser Ser Ser Pro Cys Ser Asn 
                405                 410                 415     


Gly Ala Lys Cys Val Asp Leu Gly Asp Ala Tyr Leu Cys Arg Cys Gln 
            420                 425                 430         


Ala Gly Phe Ser Gly Arg His Cys Asp Asp Asn Val Asp Asp Cys Ala 
        435                 440                 445             


Ser Ser Pro Cys Ala Asn Gly Gly Thr Cys Arg Asp Gly Val Asn Asp 
    450                 455                 460                 


Phe Ser Cys Thr Cys Pro Pro Gly Tyr Thr Gly Arg Asn Cys Ser Ala 
465                 470                 475                 480 


Pro Val Ser Arg Cys Glu His Ala Pro Cys His Asn Gly Ala Thr Cys 
                485                 490                 495     


His Glu Arg Gly His Arg Tyr Val Cys Glu Cys Ala Arg Gly Tyr Gly 
            500                 505                 510         


Gly Pro Asn Cys Gln Phe Leu Leu Pro Glu Leu Pro Pro Gly Pro Ala 
        515                 520                 525             


Val Val Asp Leu Thr Glu Lys Leu Glu Gly Gln Gly Gly Pro Phe Pro 
    530                 535                 540                 


Trp Val Ala Val Cys Ala Gly Val Ile Leu Val Leu Met Leu Leu Leu 
545                 550                 555                 560 


Gly Cys Ala Ala Val Val Val Cys Val Arg Leu Arg Leu Gln Lys His 
                565                 570                 575     


Arg Pro Pro Ala Asp Pro Cys Arg Gly Glu Thr Glu Thr Met Asn Asn 
            580                 585                 590         


Leu Ala Asn Cys Gln Arg Glu Lys Asp Ile Ser Val Ser Ile Ile Gly 
        595                 600                 605             


Ala Thr Gln Ile Lys Asn Thr Asn Lys Lys Ala Asp Phe His Gly Asp 
    610                 615                 620                 


His Ser Ala Asp Lys Asn Gly Phe Lys Ala Arg Tyr Pro Ala Val Asp 
625                 630                 635                 640 


Tyr Asn Leu Val Gln Asp Leu Lys Gly Asp Asp Thr Ala Val Arg Asp 
                645                 650                 655     


Ala His Ser Lys Arg Asp Thr Lys Cys Gln Pro Gln Gly Ser Ser Gly 
            660                 665                 670         


Glu Glu Lys Gly Thr Pro Thr Thr Leu Arg Gly Gly Glu Ala Ser Glu 
        675                 680                 685             


Arg Lys Arg Pro Asp Ser Gly Cys Ser Thr Ser Lys Asp Thr Lys Tyr 
    690                 695                 700                 


Gln Ser Val Tyr Val Ile Ser Glu Glu Lys Asp Glu Cys Val Ile Ala 
705                 710                 715                 720 


Thr Glu Val 
            


<210>  4280
<211>  220
<212>  PRT
<213>  Homo Sapiens

<400>  4280

Met Val Ser Pro Arg Met Ser Gly Leu Leu Ser Gln Thr Val Ile Leu 
1               5                   10                  15      


Ala Leu Ile Phe Leu Pro Gln Thr Arg Pro Ala Gly Val Phe Glu Leu 
            20                  25                  30          


Gln Ile His Ser Phe Gly Pro Gly Pro Gly Pro Gly Ala Pro Arg Ser 
        35                  40                  45              


Pro Cys Ser Ala Arg Leu Pro Cys Arg Leu Phe Phe Arg Val Cys Leu 
    50                  55                  60                  


Lys Pro Gly Leu Ser Glu Glu Ala Ala Glu Ser Pro Cys Ala Leu Gly 
65                  70                  75                  80  


Ala Ala Leu Ser Ala Arg Gly Pro Val Tyr Thr Glu Gln Pro Gly Ala 
                85                  90                  95      


Pro Ala Pro Asp Leu Pro Leu Pro Asp Gly Leu Leu Gln Val Pro Phe 
            100                 105                 110         


Arg Asp Ala Trp Pro Gly Thr Phe Ser Phe Ile Ile Glu Thr Trp Arg 
        115                 120                 125             


Glu Glu Leu Gly Asp Gln Ile Gly Gly Gly Leu Cys Leu Asp Leu Gly 
    130                 135                 140                 


His Ala Leu Arg Cys Arg Cys Arg Ala Gly Phe Ala Gly Pro Arg Cys 
145                 150                 155                 160 


Glu His Asp Leu Asp Asp Cys Ala Gly Arg Ala Cys Ala Asn Gly Gly 
                165                 170                 175     


Thr Cys Val Glu Gly Gly Gly Ala His Arg Cys Ser Cys Ala Leu Gly 
            180                 185                 190         


Phe Gly Gly Arg Asp Cys Arg Glu Arg Ala Asp Pro Cys Ala Ala Arg 
        195                 200                 205             


Pro Cys Ala His Gly Gly Arg Cys Tyr Ala His Phe 
    210                 215                 220 


<210>  4281
<211>  618
<212>  PRT
<213>  Homo Sapiens

<400>  4281

Met Val Ser Pro Arg Met Ser Gly Leu Leu Ser Gln Thr Val Ile Leu 
1               5                   10                  15      


Ala Leu Ile Phe Leu Pro Gln Thr Arg Pro Ala Gly Val Phe Glu Leu 
            20                  25                  30          


Gln Ile His Ser Phe Gly Pro Gly Pro Gly Pro Gly Ala Pro Arg Ser 
        35                  40                  45              


Pro Cys Ser Ala Arg Leu Pro Cys Arg Leu Phe Phe Arg Val Cys Leu 
    50                  55                  60                  


Lys Pro Gly Leu Ser Glu Glu Ala Ala Glu Ser Pro Cys Ala Leu Gly 
65                  70                  75                  80  


Ala Ala Leu Ser Ala Arg Gly Pro Val Tyr Thr Glu Gln Pro Gly Ala 
                85                  90                  95      


Pro Ala Pro Asp Leu Pro Leu Pro Asp Gly Leu Leu Gln Val Pro Phe 
            100                 105                 110         


Arg Asp Ala Trp Pro Gly Thr Phe Ser Phe Ile Ile Glu Thr Trp Arg 
        115                 120                 125             


Glu Glu Leu Gly Asp Gln Ile Gly Gly Pro Ala Trp Ser Leu Leu Ala 
    130                 135                 140                 


Arg Val Ala Gly Arg Arg Arg Leu Ala Ala Gly Gly Pro Trp Ala Arg 
145                 150                 155                 160 


Asp Ile Gln Arg Ala Gly Ala Trp Glu Leu Arg Phe Ser Tyr Arg Ala 
                165                 170                 175     


Arg Cys Glu Pro Pro Ala Val Gly Thr Ala Cys Thr Arg Leu Cys Arg 
            180                 185                 190         


Pro Arg Ser Ala Pro Ser Arg Cys Gly Pro Gly Leu Arg Pro Cys Ala 
        195                 200                 205             


Pro Leu Glu Asp Glu Cys Glu Ala Pro Leu Val Cys Arg Ala Gly Cys 
    210                 215                 220                 


Ser Pro Glu His Gly Phe Cys Glu Gln Pro Gly Glu Cys Arg Cys Leu 
225                 230                 235                 240 


Glu Gly Trp Thr Gly Pro Leu Cys Thr Val Pro Val Ser Thr Ser Ser 
                245                 250                 255     


Cys Leu Ser Pro Arg Gly Pro Ser Ser Ala Thr Thr Gly Cys Leu Val 
            260                 265                 270         


Pro Gly Pro Gly Pro Cys Asp Gly Asn Pro Cys Ala Asn Gly Gly Ser 
        275                 280                 285             


Cys Ser Glu Thr Pro Arg Ser Phe Glu Cys Thr Cys Pro Arg Gly Phe 
    290                 295                 300                 


Tyr Gly Leu Arg Cys Glu Val Ser Gly Val Thr Cys Ala Asp Gly Pro 
305                 310                 315                 320 


Cys Phe Asn Gly Gly Leu Cys Val Gly Gly Ala Asp Pro Asp Ser Ala 
                325                 330                 335     


Tyr Ile Cys His Cys Pro Pro Gly Phe Gln Gly Ser Asn Cys Glu Lys 
            340                 345                 350         


Arg Val Asp Arg Cys Ser Leu Gln Pro Cys Arg Asn Gly Gly Leu Cys 
        355                 360                 365             


Leu Asp Leu Gly His Ala Leu Arg Cys Arg Cys Arg Ala Gly Phe Ala 
    370                 375                 380                 


Gly Pro Arg Cys Glu His Asp Leu Asp Asp Cys Ala Gly Arg Ala Cys 
385                 390                 395                 400 


Ala Asn Gly Gly Thr Cys Val Glu Gly Gly Gly Ala His Arg Cys Ser 
                405                 410                 415     


Cys Ala Leu Gly Phe Gly Gly Arg Asp Cys Arg Glu Arg Ala Asp Pro 
            420                 425                 430         


Cys Ala Ala Arg Pro Cys Ala His Gly Gly Arg Cys Tyr Ala His Phe 
        435                 440                 445             


Ser Gly Leu Val Cys Ala Cys Ala Pro Gly Tyr Met Gly Ala Arg Cys 
    450                 455                 460                 


Glu Phe Pro Val His Pro Asp Gly Ala Ser Ala Leu Pro Ala Ala Pro 
465                 470                 475                 480 


Pro Gly Leu Arg Pro Gly Asp Pro Gln Arg Tyr Leu Leu Pro Pro Ala 
                485                 490                 495     


Leu Gly Leu Leu Val Ala Ala Gly Val Ala Gly Ala Ala Leu Leu Leu 
            500                 505                 510         


Val His Val Arg Arg Arg Gly His Ser Gln Asp Ala Gly Ser Arg Leu 
        515                 520                 525             


Leu Ala Gly Thr Pro Glu Pro Ser Val His Ala Leu Pro Asp Ala Leu 
    530                 535                 540                 


Asn Asn Leu Arg Thr Gln Glu Gly Ser Gly Asp Gly Pro Ser Ser Ser 
545                 550                 555                 560 


Val Asp Trp Asn Arg Pro Glu Asp Val Asp Pro Gln Gly Ile Tyr Val 
                565                 570                 575     


Ile Ser Ala Pro Ser Ile Tyr Ala Arg Glu Val Ala Thr Pro Leu Phe 
            580                 585                 590         


Pro Pro Leu His Thr Gly Arg Ala Gly Gln Arg Gln His Leu Leu Phe 
        595                 600                 605             


Pro Tyr Pro Ser Ser Ile Leu Ser Val Lys 
    610                 615             


<210>  4282
<211>  587
<212>  PRT
<213>  Homo Sapiens

<400>  4282

Met Val Ser Pro Arg Met Ser Gly Leu Leu Ser Gln Thr Val Ile Leu 
1               5                   10                  15      


Ala Leu Ile Phe Leu Pro Gln Thr Arg Pro Ala Gly Val Phe Glu Leu 
            20                  25                  30          


Gln Ile His Ser Phe Gly Pro Gly Pro Gly Pro Gly Ala Pro Arg Ser 
        35                  40                  45              


Pro Cys Ser Ala Arg Leu Pro Cys Arg Leu Phe Phe Arg Val Cys Leu 
    50                  55                  60                  


Lys Pro Gly Leu Ser Glu Glu Ala Ala Glu Ser Pro Cys Ala Leu Gly 
65                  70                  75                  80  


Ala Ala Leu Ser Ala Arg Gly Pro Val Tyr Thr Glu Gln Pro Gly Ala 
                85                  90                  95      


Pro Ala Pro Asp Leu Pro Leu Pro Asp Gly Leu Leu Gln Val Pro Phe 
            100                 105                 110         


Arg Asp Ala Trp Pro Gly Thr Phe Ser Phe Ile Ile Glu Thr Trp Arg 
        115                 120                 125             


Glu Glu Leu Gly Asp Gln Ile Gly Gly Pro Ala Trp Ser Leu Leu Ala 
    130                 135                 140                 


Arg Val Ala Gly Arg Arg Arg Leu Ala Ala Gly Gly Pro Trp Ala Arg 
145                 150                 155                 160 


Asp Ile Gln Arg Ala Gly Ala Trp Glu Leu Arg Phe Ser Tyr Arg Ala 
                165                 170                 175     


Arg Cys Glu Pro Pro Ala Val Gly Thr Ala Cys Thr Arg Leu Cys Arg 
            180                 185                 190         


Pro Arg Ser Ala Pro Ser Arg Cys Gly Pro Gly Leu Arg Pro Cys Ala 
        195                 200                 205             


Pro Leu Glu Asp Glu Cys Glu Ala Pro Leu Val Cys Arg Ala Gly Cys 
    210                 215                 220                 


Ser Pro Glu His Gly Phe Cys Glu Gln Pro Gly Glu Cys Arg Cys Leu 
225                 230                 235                 240 


Glu Gly Trp Thr Gly Pro Leu Cys Thr Val Pro Val Ser Thr Ser Ser 
                245                 250                 255     


Cys Leu Ser Pro Arg Gly Pro Ser Ser Ala Thr Thr Gly Cys Leu Val 
            260                 265                 270         


Pro Gly Pro Gly Pro Cys Asp Gly Asn Pro Cys Ala Asn Gly Gly Ser 
        275                 280                 285             


Cys Ser Glu Thr Pro Arg Ser Phe Glu Cys Thr Cys Pro Arg Gly Phe 
    290                 295                 300                 


Tyr Gly Leu Arg Cys Glu Val Ser Gly Val Thr Cys Ala Asp Gly Pro 
305                 310                 315                 320 


Cys Phe Asn Gly Gly Leu Cys Val Gly Gly Ala Asp Pro Asp Ser Ala 
                325                 330                 335     


Tyr Ile Cys His Cys Pro Pro Gly Phe Gln Gly Ser Asn Cys Glu Lys 
            340                 345                 350         


Arg Val Asp Arg Cys Ser Leu Gln Pro Cys Arg Asn Gly Gly Leu Cys 
        355                 360                 365             


Leu Asp Leu Gly His Ala Leu Arg Cys Arg Cys Arg Ala Gly Phe Ala 
    370                 375                 380                 


Gly Pro Arg Cys Glu His Asp Leu Asp Asp Cys Ala Gly Arg Ala Cys 
385                 390                 395                 400 


Ala Asn Gly Gly Thr Cys Val Glu Gly Gly Gly Ala His Arg Cys Ser 
                405                 410                 415     


Cys Ala Leu Gly Phe Gly Gly Arg Asp Cys Arg Glu Arg Ala Asp Pro 
            420                 425                 430         


Cys Ala Ala Arg Pro Cys Ala His Gly Gly Arg Cys Tyr Ala His Phe 
        435                 440                 445             


Ser Gly Leu Val Cys Ala Cys Ala Pro Gly Tyr Met Gly Ala Arg Cys 
    450                 455                 460                 


Glu Phe Pro Val His Pro Asp Gly Ala Ser Ala Leu Pro Ala Ala Pro 
465                 470                 475                 480 


Pro Gly Leu Arg Pro Gly Asp Pro Gln Arg Tyr Leu Leu Pro Pro Ala 
                485                 490                 495     


Leu Gly Leu Leu Val Ala Ala Gly Val Ala Gly Ala Ala Leu Leu Leu 
            500                 505                 510         


Val His Val Arg Arg Arg Gly His Ser Gln Asp Ala Gly Ser Arg Leu 
        515                 520                 525             


Leu Ala Gly Thr Pro Glu Pro Ser Val His Ala Leu Pro Asp Ala Leu 
    530                 535                 540                 


Asn Asn Leu Arg Thr Gln Glu Gly Ser Gly Asp Gly Pro Ser Ser Ser 
545                 550                 555                 560 


Val Asp Trp Asn Arg Pro Glu Asp Val Asp Pro Gln Gly Ile Tyr Val 
                565                 570                 575     


Ile Ser Ala Pro Ser Ile Tyr Ala Arg Glu Ala 
            580                 585         


<210>  4283
<211>  1785
<212>  PRT
<213>  Homo Sapiens

<400>  4283

Met Gly Ile Ser Thr Val Ile Leu Glu Met Cys Leu Leu Trp Gly Gln 
1               5                   10                  15      


Val Leu Ser Thr Gly Gly Trp Ile Pro Arg Thr Thr Asp Tyr Ala Ser 
            20                  25                  30          


Leu Ile Pro Ser Glu Val Pro Leu Asp Pro Thr Val Ala Glu Gly Ser 
        35                  40                  45              


Pro Phe Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
    50                  55                  60                  


Pro Ile Ser Leu Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
65                  70                  75                  80  


Leu Ile Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
                85                  90                  95      


Asp Ser Gly Leu Ala Leu Arg Leu Val Asn Gly Asp Gly Arg Cys Gln 
            100                 105                 110         


Gly Arg Val Glu Ile Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp 
        115                 120                 125             


Asp Ser Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly 
    130                 135                 140                 


Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Trp Phe Gly Gln Gly 
145                 150                 155                 160 


Ser Gly Pro Ile Ala Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser 
                165                 170                 175     


Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly 
            180                 185                 190         


His Gly Glu Asp Ala Gly Val Ile Cys Ser Ala Ala Gln Pro Gln Ser 
        195                 200                 205             


Thr Leu Arg Pro Glu Ser Trp Pro Val Arg Ile Ser Pro Pro Val Pro 
    210                 215                 220                 


Thr Glu Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly 
225                 230                 235                 240 


Asp Arg Cys Arg Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp Gly 
                245                 250                 255     


Thr Val Cys Asp Asp Tyr Trp Asp Thr Asn Asp Ala Asn Val Val Cys 
            260                 265                 270         


Arg Gln Leu Gly Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Gln 
        275                 280                 285             


Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser 
    290                 295                 300                 


Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Thr 
305                 310                 315                 320 


His Asn Cys Gly His Ser Glu Asp Ala Gly Val Ile Cys Ser Ala Pro 
                325                 330                 335     


Gln Ser Arg Pro Thr Pro Ser Pro Asp Thr Trp Pro Thr Ser His Ala 
            340                 345                 350         


Ser Thr Ala Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly 
        355                 360                 365             


Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp 
    370                 375                 380                 


Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Ser Asp Ala Asn Val Val 
385                 390                 395                 400 


Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly Asn Ala 
                405                 410                 415     


Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys 
            420                 425                 430         


Ser Gly Tyr Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu 
        435                 440                 445             


Ser His Asn Cys Gln His Ser Glu Asp Ala Gly Val Ile Cys Ser Ala 
    450                 455                 460                 


Ala His Ser Trp Ser Thr Pro Ser Pro Asp Thr Leu Pro Thr Ile Thr 
465                 470                 475                 480 


Leu Pro Ala Ser Thr Val Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu 
                485                 490                 495     


Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Gln 
            500                 505                 510         


Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Asn Asp Ala 
        515                 520                 525             


Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Met Ser Ala Pro 
    530                 535                 540                 


Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp 
545                 550                 555                 560 


Val Arg Cys Ser Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His Asn 
                565                 570                 575     


Gly Trp Leu Ser His Asn Cys Gly His Ser Glu Asp Ala Gly Val Ile 
            580                 585                 590         


Cys Ser Ala Ser Gln Ser Arg Pro Thr Pro Ser Pro Asp Thr Trp Pro 
        595                 600                 605             


Thr Ser His Ala Ser Thr Ala Gly Ser Glu Ser Ser Leu Ala Leu Arg 
    610                 615                 620                 


Leu Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr 
625                 630                 635                 640 


Arg Gly Ser Trp Gly Thr Val Cys Asp Asp Tyr Trp Asp Thr Asn Asp 
                645                 650                 655     


Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Met Ser Ala 
            660                 665                 670         


Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp 
        675                 680                 685             


Asp Val Arg Cys Ser Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His 
    690                 695                 700                 


Asn Gly Trp Leu Ser His Asn Cys Gly His His Glu Asp Ala Gly Val 
705                 710                 715                 720 


Ile Cys Ser Ala Ser Gln Ser Gln Pro Thr Pro Ser Pro Asp Thr Trp 
                725                 730                 735     


Pro Thr Ser His Ala Ser Thr Ala Gly Ser Glu Ser Ser Leu Ala Leu 
            740                 745                 750         


Arg Leu Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu 
        755                 760                 765             


Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp Asp Tyr Trp Asp Thr Asn 
    770                 775                 780                 


Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser 
785                 790                 795                 800 


Ala Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu 
                805                 810                 815     


Asp Asp Val Arg Cys Ser Gly His Glu Ser Tyr Leu Trp Ser Cys Pro 
            820                 825                 830         


His Asn Gly Trp Leu Ser His Asn Cys Gly His His Glu Asp Ala Gly 
        835                 840                 845             


Val Ile Cys Ser Ala Ser Gln Ser Gln Pro Thr Pro Ser Pro Asp Thr 
    850                 855                 860                 


Trp Pro Thr Ser Arg Ala Ser Thr Ala Gly Ser Glu Ser Thr Leu Ala 
865                 870                 875                 880 


Leu Arg Leu Val Asn Gly Gly Asp Arg Cys Arg Gly Arg Val Glu Val 
                885                 890                 895     


Leu Tyr Gln Gly Ser Trp Gly Thr Val Cys Asp Asp Tyr Trp Asp Thr 
            900                 905                 910         


Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Met 
        915                 920                 925             


Ser Ala Pro Gly Asn Ala Gln Phe Gly Gln Gly Ser Gly Pro Ile Val 
    930                 935                 940                 


Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser Tyr Leu Trp Ser Cys 
945                 950                 955                 960 


Pro His Asn Gly Trp Leu Ser His Asn Cys Gly His His Glu Asp Ala 
                965                 970                 975     


Gly Val Ile Cys Ser Ala Ala Gln Ser Gln Ser Thr Pro Arg Pro Asp 
            980                 985                 990         


Thr Trp Leu Thr Thr Asn Leu Pro  Ala Leu Thr Val Gly  Ser Glu Ser 
        995                 1000                 1005             


Ser Leu  Ala Leu Arg Leu Val  Asn Gly Gly Asp Arg  Cys Arg Gly 
    1010                 1015                 1020             


Arg Val  Glu Val Leu Tyr Arg  Gly Ser Trp Gly Thr  Val Cys Asp 
    1025                 1030                 1035             


Asp Ser  Trp Asp Thr Asn Asp  Ala Asn Val Val Cys  Arg Gln Leu 
    1040                 1045                 1050             


Gly Cys  Gly Trp Ala Met Ser  Ala Pro Gly Asn Ala  Arg Phe Gly 
    1055                 1060                 1065             


Gln Gly  Ser Gly Pro Ile Val  Leu Asp Asp Val Arg  Cys Ser Gly 
    1070                 1075                 1080             


Asn Glu  Ser Tyr Leu Trp Ser  Cys Pro His Lys Gly  Trp Leu Thr 
    1085                 1090                 1095             


His Asn  Cys Gly His His Glu  Asp Ala Gly Val Ile  Cys Ser Ala 
    1100                 1105                 1110             


Thr Gln  Ile Asn Ser Thr Thr  Thr Asp Trp Trp His  Pro Thr Thr 
    1115                 1120                 1125             


Thr Thr  Thr Ala Arg Pro Ser  Ser Asn Cys Gly Gly  Phe Leu Phe 
    1130                 1135                 1140             


Tyr Ala  Ser Gly Thr Phe Ser  Ser Pro Ser Tyr Pro  Ala Tyr Tyr 
    1145                 1150                 1155             


Pro Asn  Asn Ala Lys Cys Val  Trp Glu Ile Glu Val  Asn Ser Gly 
    1160                 1165                 1170             


Tyr Arg  Ile Asn Leu Gly Phe  Ser Asn Leu Lys Leu  Glu Ala His 
    1175                 1180                 1185             


His Asn  Cys Ser Phe Asp Tyr  Val Glu Ile Phe Asp  Gly Ser Leu 
    1190                 1195                 1200             


Asn Ser  Ser Leu Leu Leu Gly  Lys Ile Cys Asn Asp  Thr Arg Gln 
    1205                 1210                 1215             


Ile Phe  Thr Ser Ser Tyr Asn  Arg Met Thr Ile His  Phe Arg Ser 
    1220                 1225                 1230             


Asp Ile  Ser Phe Gln Asn Thr  Gly Phe Leu Ala Trp  Tyr Asn Ser 
    1235                 1240                 1245             


Phe Pro  Ser Asp Ala Thr Leu  Arg Leu Val Asn Leu  Asn Ser Ser 
    1250                 1255                 1260             


Tyr Gly  Leu Cys Ala Gly Arg  Val Glu Ile Tyr His  Gly Gly Thr 
    1265                 1270                 1275             


Trp Gly  Thr Val Cys Asp Asp  Ser Trp Thr Ile Gln  Glu Ala Glu 
    1280                 1285                 1290             


Val Val  Cys Arg Gln Leu Gly  Cys Gly Arg Ala Val  Ser Ala Leu 
    1295                 1300                 1305             


Gly Asn  Ala Tyr Phe Gly Ser  Gly Ser Gly Pro Ile  Thr Leu Asp 
    1310                 1315                 1320             


Asp Val  Glu Cys Ser Gly Thr  Glu Ser Thr Leu Trp  Gln Cys Arg 
    1325                 1330                 1335             


Asn Arg  Gly Trp Phe Ser His  Asn Cys Asn His Arg  Glu Asp Ala 
    1340                 1345                 1350             


Gly Val  Ile Cys Ser Gly Asn  His Leu Ser Thr Pro  Ala Pro Phe 
    1355                 1360                 1365             


Leu Asn  Ile Thr Arg Pro Asn  Thr Asp Tyr Ser Cys  Gly Gly Phe 
    1370                 1375                 1380             


Leu Ser  Gln Pro Ser Gly Asp  Phe Ser Ser Pro Phe  Tyr Pro Gly 
    1385                 1390                 1395             


Asn Tyr  Pro Asn Asn Ala Lys  Cys Val Trp Asp Ile  Glu Val Gln 
    1400                 1405                 1410             


Asn Asn  Tyr Arg Val Thr Val  Ile Phe Arg Asp Val  Gln Leu Glu 
    1415                 1420                 1425             


Gly Gly  Cys Asn Tyr Asp Tyr  Ile Glu Val Phe Asp  Gly Pro Tyr 
    1430                 1435                 1440             


Arg Ser  Ser Pro Leu Ile Ala  Arg Val Cys Asp Gly  Ala Arg Gly 
    1445                 1450                 1455             


Ser Phe  Thr Ser Ser Ser Asn  Phe Met Ser Ile Arg  Phe Ile Ser 
    1460                 1465                 1470             


Asp His  Ser Ile Thr Arg Arg  Gly Phe Arg Ala Glu  Tyr Tyr Ser 
    1475                 1480                 1485             


Ser Pro  Ser Asn Asp Ser Thr  Asn Leu Leu Cys Leu  Pro Asn His 
    1490                 1495                 1500             


Met Gln  Ala Ser Val Ser Arg  Ser Tyr Leu Gln Ser  Leu Gly Phe 
    1505                 1510                 1515             


Ser Ala  Ser Asp Leu Val Ile  Ser Thr Trp Asn Gly  Tyr Tyr Glu 
    1520                 1525                 1530             


Cys Arg  Pro Gln Ile Thr Pro  Asn Leu Val Ile Phe  Thr Ile Pro 
    1535                 1540                 1545             


Tyr Ser  Gly Cys Gly Thr Phe  Lys Gln Ala Asp Asn  Asp Thr Ile 
    1550                 1555                 1560             


Asp Tyr  Ser Asn Phe Leu Thr  Ala Ala Val Ser Gly  Gly Ile Ile 
    1565                 1570                 1575             


Lys Arg  Arg Thr Asp Leu Arg  Ile His Val Ser Cys  Arg Met Leu 
    1580                 1585                 1590             


Gln Asn  Thr Trp Val Asp Thr  Met Tyr Ile Ala Asn  Asp Thr Ile 
    1595                 1600                 1605             


His Val  Ala Asn Asn Thr Ile  Gln Val Glu Glu Val  Gln Tyr Gly 
    1610                 1615                 1620             


Asn Phe  Asp Val Asn Ile Ser  Phe Tyr Thr Ser Ser  Ser Phe Leu 
    1625                 1630                 1635             


Tyr Pro  Val Thr Ser Arg Pro  Tyr Tyr Val Asp Leu  Asn Gln Asp 
    1640                 1645                 1650             


Leu Tyr  Val Gln Ala Glu Ile  Leu His Ser Asp Ala  Val Leu Thr 
    1655                 1660                 1665             


Leu Phe  Val Asp Thr Cys Val  Ala Ser Pro Tyr Ser  Asn Asp Phe 
    1670                 1675                 1680             


Thr Ser  Leu Thr Tyr Asp Leu  Ile Arg Ser Gly Cys  Val Arg Asp 
    1685                 1690                 1695             


Asp Thr  Tyr Gly Pro Tyr Ser  Ser Pro Ser Leu Arg  Ile Ala Arg 
    1700                 1705                 1710             


Phe Arg  Phe Arg Ala Phe His  Phe Leu Asn Arg Phe  Pro Ser Val 
    1715                 1720                 1725             


Tyr Leu  Arg Cys Lys Met Val  Val Cys Arg Ala Tyr  Asp Pro Ser 
    1730                 1735                 1740             


Ser Arg  Cys Tyr Arg Gly Cys  Val Leu Arg Ser Lys  Arg Asp Val 
    1745                 1750                 1755             


Gly Ser  Tyr Gln Glu Lys Val  Asp Val Val Leu Gly  Pro Ile Gln 
    1760                 1765                 1770             


Leu Gln  Thr Pro Pro Arg Arg  Glu Glu Glu Pro Arg  
    1775                 1780                 1785 


<210>  4284
<211>  2413
<212>  PRT
<213>  Homo Sapiens

<400>  4284

Met Gly Ile Ser Thr Val Ile Leu Glu Met Cys Leu Leu Trp Gly Gln 
1               5                   10                  15      


Val Leu Ser Thr Gly Gly Trp Ile Pro Arg Thr Thr Asp Tyr Ala Ser 
            20                  25                  30          


Leu Ile Pro Ser Glu Val Pro Leu Asp Pro Thr Val Ala Glu Gly Ser 
        35                  40                  45              


Pro Phe Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
    50                  55                  60                  


Pro Ile Ser Leu Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
65                  70                  75                  80  


Leu Ile Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
                85                  90                  95      


Asp Ser Gly Leu Ala Leu Arg Leu Val Asn Gly Asp Gly Arg Cys Gln 
            100                 105                 110         


Gly Arg Val Glu Ile Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp 
        115                 120                 125             


Asp Ser Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly 
    130                 135                 140                 


Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Trp Phe Gly Gln Gly 
145                 150                 155                 160 


Ser Gly Pro Ile Ala Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser 
                165                 170                 175     


Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly 
            180                 185                 190         


His Gly Glu Asp Ala Gly Val Ile Cys Ser Ala Ala Gln Pro Gln Ser 
        195                 200                 205             


Thr Leu Arg Pro Glu Ser Trp Pro Val Arg Ile Ser Pro Pro Val Pro 
    210                 215                 220                 


Thr Glu Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly 
225                 230                 235                 240 


Asp Arg Cys Arg Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp Gly 
                245                 250                 255     


Thr Val Cys Asp Asp Tyr Trp Asp Thr Asn Asp Ala Asn Val Val Cys 
            260                 265                 270         


Arg Gln Leu Gly Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Gln 
        275                 280                 285             


Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser 
    290                 295                 300                 


Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Thr 
305                 310                 315                 320 


His Asn Cys Gly His Ser Glu Asp Ala Gly Val Ile Cys Ser Ala Pro 
                325                 330                 335     


Gln Ser Arg Pro Thr Pro Ser Pro Asp Thr Trp Pro Thr Ser His Ala 
            340                 345                 350         


Ser Thr Ala Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly 
        355                 360                 365             


Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp 
    370                 375                 380                 


Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Ser Asp Ala Asn Val Val 
385                 390                 395                 400 


Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly Asn Ala 
                405                 410                 415     


Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys 
            420                 425                 430         


Ser Gly Tyr Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu 
        435                 440                 445             


Ser His Asn Cys Gln His Ser Glu Asp Ala Gly Val Ile Cys Ser Ala 
    450                 455                 460                 


Ala His Ser Trp Ser Thr Pro Ser Pro Asp Thr Leu Pro Thr Ile Thr 
465                 470                 475                 480 


Leu Pro Ala Ser Thr Val Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu 
                485                 490                 495     


Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg 
            500                 505                 510         


Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Asn Asp Ala 
        515                 520                 525             


Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Met Leu Ala Pro 
    530                 535                 540                 


Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp 
545                 550                 555                 560 


Val Arg Cys Ser Gly Asn Glu Ser Tyr Leu Trp Ser Cys Pro His Asn 
                565                 570                 575     


Gly Trp Leu Ser His Asn Cys Gly His Ser Glu Asp Ala Gly Val Ile 
            580                 585                 590         


Cys Ser Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly 
        595                 600                 605             


Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp Gly 
    610                 615                 620                 


Thr Val Cys Asp Asp Ser Trp Asp Thr Asn Asp Ala Asn Val Val Cys 
625                 630                 635                 640 


Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly Asn Ala Arg 
                645                 650                 655     


Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser 
            660                 665                 670         


Gly His Glu Ser Tyr Leu Trp Ser Cys Pro Asn Asn Gly Trp Leu Ser 
        675                 680                 685             


His Asn Cys Gly His His Glu Asp Ala Gly Val Ile Cys Ser Ala Ala 
    690                 695                 700                 


Gln Ser Arg Ser Thr Pro Arg Pro Asp Thr Leu Ser Thr Ile Thr Leu 
705                 710                 715                 720 


Pro Pro Ser Thr Val Gly Ser Glu Ser Ser Leu Thr Leu Arg Leu Val 
                725                 730                 735     


Asn Gly Ser Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly 
            740                 745                 750         


Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Asn Asp Ala Asn 
        755                 760                 765             


Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly 
    770                 775                 780                 


Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val 
785                 790                 795                 800 


Arg Cys Ser Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly 
                805                 810                 815     


Trp Leu Ser His Asn Cys Gly His His Glu Asp Ala Gly Val Ile Cys 
            820                 825                 830         


Ser Val Ser Gln Ser Arg Pro Thr Pro Ser Pro Asp Thr Trp Pro Thr 
        835                 840                 845             


Ser His Ala Ser Thr Ala Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu 
    850                 855                 860                 


Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg 
865                 870                 875                 880 


Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Ser Asp Ala 
                885                 890                 895     


Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro 
            900                 905                 910         


Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp 
        915                 920                 925             


Val Arg Cys Ser Gly Tyr Glu Ser Tyr Leu Trp Ser Cys Pro His Asn 
    930                 935                 940                 


Gly Trp Leu Ser His Asn Cys Gln His Ser Glu Asp Ala Gly Val Ile 
945                 950                 955                 960 


Cys Ser Ala Ala His Ser Trp Ser Thr Pro Ser Pro Asp Thr Leu Pro 
                965                 970                 975     


Thr Ile Thr Leu Pro Ala Ser Thr Val Gly Ser Glu Ser Ser Leu Ala 
            980                 985                 990         


Leu Arg Leu Val Asn Gly Gly Asp  Arg Cys Gln Gly Arg  Val Glu Val 
        995                 1000                 1005             


Leu Tyr  Gln Gly Ser Trp Gly  Thr Val Cys Asp Asp  Ser Trp Asp 
    1010                 1015                 1020             


Thr Asn  Asp Ala Asn Val Val  Cys Arg Gln Leu Gly  Cys Gly Trp 
    1025                 1030                 1035             


Ala Met  Ser Ala Pro Gly Asn  Ala Arg Phe Gly Gln  Gly Ser Gly 
    1040                 1045                 1050             


Pro Ile  Val Leu Asp Asp Val  Arg Cys Ser Gly His  Glu Ser Tyr 
    1055                 1060                 1065             


Leu Trp  Ser Cys Pro His Asn  Gly Trp Leu Ser His  Asn Cys Gly 
    1070                 1075                 1080             


His Ser  Glu Asp Ala Gly Val  Ile Cys Ser Ala Ser  Gln Ser Arg 
    1085                 1090                 1095             


Pro Thr  Pro Ser Pro Asp Thr  Trp Pro Thr Ser His  Ala Ser Thr 
    1100                 1105                 1110             


Ala Gly  Ser Glu Ser Ser Leu  Ala Leu Arg Leu Val  Asn Gly Gly 
    1115                 1120                 1125             


Asp Arg  Cys Gln Gly Arg Val  Glu Val Leu Tyr Arg  Gly Ser Trp 
    1130                 1135                 1140             


Gly Thr  Val Cys Asp Asp Tyr  Trp Asp Thr Asn Asp  Ala Asn Val 
    1145                 1150                 1155             


Val Cys  Arg Gln Leu Gly Cys  Gly Trp Ala Met Ser  Ala Pro Gly 
    1160                 1165                 1170             


Asn Ala  Arg Phe Gly Gln Gly  Ser Gly Pro Ile Val  Leu Asp Asp 
    1175                 1180                 1185             


Val Arg  Cys Ser Gly His Glu  Ser Tyr Leu Trp Ser  Cys Pro His 
    1190                 1195                 1200             


Asn Gly  Trp Leu Ser His Asn  Cys Gly His His Glu  Asp Ala Gly 
    1205                 1210                 1215             


Val Ile  Cys Ser Ala Ser Gln  Ser Gln Pro Thr Pro  Ser Pro Asp 
    1220                 1225                 1230             


Thr Trp  Pro Thr Ser His Ala  Ser Thr Ala Gly Ser  Glu Ser Ser 
    1235                 1240                 1245             


Leu Ala  Leu Arg Leu Val Asn  Gly Gly Asp Arg Cys  Gln Gly Arg 
    1250                 1255                 1260             


Val Glu  Val Leu Tyr Arg Gly  Ser Trp Gly Thr Val  Cys Asp Asp 
    1265                 1270                 1275             


Tyr Trp  Asp Thr Asn Asp Ala  Asn Val Val Cys Arg  Gln Leu Gly 
    1280                 1285                 1290             


Cys Gly  Trp Ala Thr Ser Ala  Pro Gly Asn Ala Arg  Phe Gly Gln 
    1295                 1300                 1305             


Gly Ser  Gly Pro Ile Val Leu  Asp Asp Val Arg Cys  Ser Gly His 
    1310                 1315                 1320             


Glu Ser  Tyr Leu Trp Ser Cys  Pro His Asn Gly Trp  Leu Ser His 
    1325                 1330                 1335             


Asn Cys  Gly His His Glu Asp  Ala Gly Val Ile Cys  Ser Ala Ser 
    1340                 1345                 1350             


Gln Ser  Gln Pro Thr Pro Ser  Pro Asp Thr Trp Pro  Thr Ser His 
    1355                 1360                 1365             


Ala Ser  Thr Ala Gly Ser Glu  Ser Ser Leu Ala Leu  Arg Leu Val 
    1370                 1375                 1380             


Asn Gly  Gly Asp Arg Cys Gln  Gly Arg Val Glu Val  Leu Tyr Arg 
    1385                 1390                 1395             


Gly Ser  Trp Gly Thr Val Cys  Asp Asp Tyr Trp Asp  Thr Asn Asp 
    1400                 1405                 1410             


Ala Asn  Val Val Cys Arg Gln  Leu Gly Cys Gly Trp  Ala Thr Ser 
    1415                 1420                 1425             


Ala Pro  Gly Asn Ala Arg Phe  Gly Gln Gly Ser Gly  Pro Ile Val 
    1430                 1435                 1440             


Leu Asp  Asp Val Arg Cys Ser  Gly His Glu Ser Tyr  Leu Trp Ser 
    1445                 1450                 1455             


Cys Pro  His Asn Gly Trp Leu  Ser His Asn Cys Gly  His His Glu 
    1460                 1465                 1470             


Asp Ala  Gly Val Ile Cys Ser  Ala Ser Gln Ser Gln  Pro Thr Pro 
    1475                 1480                 1485             


Ser Pro  Asp Thr Trp Pro Thr  Ser Arg Ala Ser Thr  Ala Gly Ser 
    1490                 1495                 1500             


Glu Ser  Thr Leu Ala Leu Arg  Leu Val Asn Gly Gly  Asp Arg Cys 
    1505                 1510                 1515             


Arg Gly  Arg Val Glu Val Leu  Tyr Gln Gly Ser Trp  Gly Thr Val 
    1520                 1525                 1530             


Cys Asp  Asp Tyr Trp Asp Thr  Asn Asp Ala Asn Val  Val Cys Arg 
    1535                 1540                 1545             


Gln Leu  Gly Cys Gly Trp Ala  Met Ser Ala Pro Gly  Asn Ala Gln 
    1550                 1555                 1560             


Phe Gly  Gln Gly Ser Gly Pro  Ile Val Leu Asp Asp  Val Arg Cys 
    1565                 1570                 1575             


Ser Gly  His Glu Ser Tyr Leu  Trp Ser Cys Pro His  Asn Gly Trp 
    1580                 1585                 1590             


Leu Ser  His Asn Cys Gly His  His Glu Asp Ala Gly  Val Ile Cys 
    1595                 1600                 1605             


Ser Ala  Ala Gln Ser Gln Ser  Thr Pro Arg Pro Asp  Thr Trp Leu 
    1610                 1615                 1620             


Thr Thr  Asn Leu Pro Ala Leu  Thr Val Gly Ser Glu  Ser Ser Leu 
    1625                 1630                 1635             


Ala Leu  Arg Leu Val Asn Gly  Gly Asp Arg Cys Arg  Gly Arg Val 
    1640                 1645                 1650             


Glu Val  Leu Tyr Arg Gly Ser  Trp Gly Thr Val Cys  Asp Asp Ser 
    1655                 1660                 1665             


Trp Asp  Thr Asn Asp Ala Asn  Val Val Cys Arg Gln  Leu Gly Cys 
    1670                 1675                 1680             


Gly Trp  Ala Met Ser Ala Pro  Gly Asn Ala Arg Phe  Gly Gln Gly 
    1685                 1690                 1695             


Ser Gly  Pro Ile Val Leu Asp  Asp Val Arg Cys Ser  Gly Asn Glu 
    1700                 1705                 1710             


Ser Tyr  Leu Trp Ser Cys Pro  His Lys Gly Trp Leu  Thr His Asn 
    1715                 1720                 1725             


Cys Gly  His His Glu Asp Ala  Gly Val Ile Cys Ser  Ala Thr Gln 
    1730                 1735                 1740             


Ile Asn  Ser Thr Thr Thr Asp  Trp Trp His Pro Thr  Thr Thr Thr 
    1745                 1750                 1755             


Thr Ala  Arg Pro Ser Ser Asn  Cys Gly Gly Phe Leu  Phe Tyr Ala 
    1760                 1765                 1770             


Ser Gly  Thr Phe Ser Ser Pro  Ser Tyr Pro Ala Tyr  Tyr Pro Asn 
    1775                 1780                 1785             


Asn Ala  Lys Cys Val Trp Glu  Ile Glu Val Asn Ser  Gly Tyr Arg 
    1790                 1795                 1800             


Ile Asn  Leu Gly Phe Ser Asn  Leu Lys Leu Glu Ala  His His Asn 
    1805                 1810                 1815             


Cys Ser  Phe Asp Tyr Val Glu  Ile Phe Asp Gly Ser  Leu Asn Ser 
    1820                 1825                 1830             


Ser Leu  Leu Leu Gly Lys Ile  Cys Asn Asp Thr Arg  Gln Ile Phe 
    1835                 1840                 1845             


Thr Ser  Ser Tyr Asn Arg Met  Thr Ile His Phe Arg  Ser Asp Ile 
    1850                 1855                 1860             


Ser Phe  Gln Asn Thr Gly Phe  Leu Ala Trp Tyr Asn  Ser Phe Pro 
    1865                 1870                 1875             


Ser Asp  Ala Thr Leu Arg Leu  Val Asn Leu Asn Ser  Ser Tyr Gly 
    1880                 1885                 1890             


Leu Cys  Ala Gly Arg Val Glu  Ile Tyr His Gly Gly  Thr Trp Gly 
    1895                 1900                 1905             


Thr Val  Cys Asp Asp Ser Trp  Thr Ile Gln Glu Ala  Glu Val Val 
    1910                 1915                 1920             


Cys Arg  Gln Leu Gly Cys Gly  Arg Ala Val Ser Ala  Leu Gly Asn 
    1925                 1930                 1935             


Ala Tyr  Phe Gly Ser Gly Ser  Gly Pro Ile Thr Leu  Asp Asp Val 
    1940                 1945                 1950             


Glu Cys  Ser Gly Thr Glu Ser  Thr Leu Trp Gln Cys  Arg Asn Arg 
    1955                 1960                 1965             


Gly Trp  Phe Ser His Asn Cys  Asn His Arg Glu Asp  Ala Gly Val 
    1970                 1975                 1980             


Ile Cys  Ser Gly Asn His Leu  Ser Thr Pro Ala Pro  Phe Leu Asn 
    1985                 1990                 1995             


Ile Thr  Arg Pro Asn Thr Asp  Tyr Ser Cys Gly Gly  Phe Leu Ser 
    2000                 2005                 2010             


Gln Pro  Ser Gly Asp Phe Ser  Ser Pro Phe Tyr Pro  Gly Asn Tyr 
    2015                 2020                 2025             


Pro Asn  Asn Ala Lys Cys Val  Trp Asp Ile Glu Val  Gln Asn Asn 
    2030                 2035                 2040             


Tyr Arg  Val Thr Val Ile Phe  Arg Asp Val Gln Leu  Glu Gly Gly 
    2045                 2050                 2055             


Cys Asn  Tyr Asp Tyr Ile Glu  Val Phe Asp Gly Pro  Tyr Arg Ser 
    2060                 2065                 2070             


Ser Pro  Leu Ile Ala Arg Val  Cys Asp Gly Ala Arg  Gly Ser Phe 
    2075                 2080                 2085             


Thr Ser  Ser Ser Asn Phe Met  Ser Ile Arg Phe Ile  Ser Asp His 
    2090                 2095                 2100             


Ser Ile  Thr Arg Arg Gly Phe  Arg Ala Glu Tyr Tyr  Ser Ser Pro 
    2105                 2110                 2115             


Ser Asn  Asp Ser Thr Asn Leu  Leu Cys Leu Pro Asn  His Met Gln 
    2120                 2125                 2130             


Ala Ser  Val Ser Arg Ser Tyr  Leu Gln Ser Leu Gly  Phe Ser Ala 
    2135                 2140                 2145             


Ser Asp  Leu Val Ile Ser Thr  Trp Asn Gly Tyr Tyr  Glu Cys Arg 
    2150                 2155                 2160             


Pro Gln  Ile Thr Pro Asn Leu  Val Ile Phe Thr Ile  Pro Tyr Ser 
    2165                 2170                 2175             


Gly Cys  Gly Thr Phe Lys Gln  Ala Asp Asn Asp Thr  Ile Asp Tyr 
    2180                 2185                 2190             


Ser Asn  Phe Leu Thr Ala Ala  Val Ser Gly Gly Ile  Ile Lys Arg 
    2195                 2200                 2205             


Arg Thr  Asp Leu Arg Ile His  Val Ser Cys Arg Met  Leu Gln Asn 
    2210                 2215                 2220             


Thr Trp  Val Asp Thr Met Tyr  Ile Ala Asn Asp Thr  Ile His Val 
    2225                 2230                 2235             


Ala Asn  Asn Thr Ile Gln Val  Glu Glu Val Gln Tyr  Gly Asn Phe 
    2240                 2245                 2250             


Asp Val  Asn Ile Ser Phe Tyr  Thr Ser Ser Ser Phe  Leu Tyr Pro 
    2255                 2260                 2265             


Val Thr  Ser Arg Pro Tyr Tyr  Val Asp Leu Asn Gln  Asp Leu Tyr 
    2270                 2275                 2280             


Val Gln  Ala Glu Ile Leu His  Ser Asp Ala Val Leu  Thr Leu Phe 
    2285                 2290                 2295             


Val Asp  Thr Cys Val Ala Ser  Pro Tyr Ser Asn Asp  Phe Thr Ser 
    2300                 2305                 2310             


Leu Thr  Tyr Asp Leu Ile Arg  Ser Gly Cys Val Arg  Asp Asp Thr 
    2315                 2320                 2325             


Tyr Gly  Pro Tyr Ser Ser Pro  Ser Leu Arg Ile Ala  Arg Phe Arg 
    2330                 2335                 2340             


Phe Arg  Ala Phe His Phe Leu  Asn Arg Phe Pro Ser  Val Tyr Leu 
    2345                 2350                 2355             


Arg Cys  Lys Met Val Val Cys  Arg Ala Tyr Asp Pro  Ser Ser Arg 
    2360                 2365                 2370             


Cys Tyr  Arg Gly Cys Val Leu  Arg Ser Lys Arg Asp  Val Gly Ser 
    2375                 2380                 2385             


Tyr Gln  Glu Lys Val Asp Val  Val Leu Gly Pro Ile  Gln Leu Gln 
    2390                 2395                 2400             


Thr Pro  Pro Arg Arg Glu Glu  Glu Pro Arg 
    2405                 2410             


<210>  4285
<211>  2403
<212>  PRT
<213>  Homo Sapiens

<400>  4285

Met Gly Ile Ser Thr Val Ile Leu Glu Met Cys Leu Leu Trp Gly Gln 
1               5                   10                  15      


Val Leu Ser Thr Gly Gly Trp Ile Pro Arg Thr Thr Asp Tyr Ala Ser 
            20                  25                  30          


Leu Ile Pro Ser Glu Val Pro Leu Asp Pro Thr Val Ala Glu Gly Ser 
        35                  40                  45              


Pro Phe Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
    50                  55                  60                  


Pro Ile Ser Leu Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
65                  70                  75                  80  


Leu Ile Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
                85                  90                  95      


Asp Ser Gly Leu Ala Leu Arg Leu Val Asn Gly Asp Gly Arg Cys Gln 
            100                 105                 110         


Gly Arg Val Glu Ile Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp 
        115                 120                 125             


Asp Ser Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly 
    130                 135                 140                 


Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Trp Phe Gly Gln Gly 
145                 150                 155                 160 


Ser Gly Pro Ile Ala Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser 
                165                 170                 175     


Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly 
            180                 185                 190         


His Gly Glu Asp Ala Gly Val Ile Cys Ser Ala Ala Gln Pro Gln Ser 
        195                 200                 205             


Thr Leu Arg Pro Glu Ser Trp Pro Val Arg Ile Ser Pro Pro Val Pro 
    210                 215                 220                 


Thr Glu Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly 
225                 230                 235                 240 


Asp Arg Cys Arg Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp Gly 
                245                 250                 255     


Thr Val Cys Asp Asp Tyr Trp Asp Thr Asn Asp Ala Asn Val Val Cys 
            260                 265                 270         


Arg Gln Leu Gly Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Gln 
        275                 280                 285             


Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser 
    290                 295                 300                 


Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Thr 
305                 310                 315                 320 


His Asn Cys Gly His Ser Glu Asp Ala Gly Val Ile Cys Ser Ala Pro 
                325                 330                 335     


Gln Ser Arg Pro Thr Pro Ser Pro Asp Thr Trp Pro Thr Ser His Ala 
            340                 345                 350         


Ser Thr Ala Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly 
        355                 360                 365             


Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp 
    370                 375                 380                 


Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Ser Asp Ala Asn Val Val 
385                 390                 395                 400 


Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly Asn Ala 
                405                 410                 415     


Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys 
            420                 425                 430         


Ser Gly Tyr Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu 
        435                 440                 445             


Ser His Asn Cys Gln His Ser Glu Asp Ala Gly Val Ile Cys Ser Asp 
    450                 455                 460                 


Thr Leu Pro Thr Ile Thr Leu Pro Ala Ser Thr Val Gly Ser Glu Ser 
465                 470                 475                 480 


Ser Leu Ala Leu Arg Leu Val Asn Gly Gly Asp Arg Cys Gln Gly Arg 
                485                 490                 495     


Val Glu Val Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp Asp Ser 
            500                 505                 510         


Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly 
        515                 520                 525             


Trp Ala Met Leu Ala Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly 
    530                 535                 540                 


Pro Ile Val Leu Asp Asp Val Arg Cys Ser Gly Asn Glu Ser Tyr Leu 
545                 550                 555                 560 


Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly His Ser 
                565                 570                 575     


Glu Asp Ala Gly Val Ile Cys Ser Gly Pro Glu Ser Ser Leu Ala Leu 
            580                 585                 590         


Arg Leu Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu 
        595                 600                 605             


Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Asn 
    610                 615                 620                 


Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser 
625                 630                 635                 640 


Ala Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu 
                645                 650                 655     


Asp Asp Val Arg Cys Ser Gly His Glu Ser Tyr Leu Trp Ser Cys Pro 
            660                 665                 670         


Asn Asn Gly Trp Leu Ser His Asn Cys Gly His His Glu Asp Ala Gly 
        675                 680                 685             


Val Ile Cys Ser Ala Ala Gln Ser Arg Ser Thr Pro Arg Pro Asp Thr 
    690                 695                 700                 


Leu Ser Thr Ile Thr Leu Pro Pro Ser Thr Val Gly Ser Glu Ser Ser 
705                 710                 715                 720 


Leu Thr Leu Arg Leu Val Asn Gly Ser Asp Arg Cys Gln Gly Arg Val 
                725                 730                 735     


Glu Val Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp 
            740                 745                 750         


Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp 
        755                 760                 765             


Ala Thr Ser Ala Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro 
    770                 775                 780                 


Ile Val Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser Tyr Leu Trp 
785                 790                 795                 800 


Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly His His Glu 
                805                 810                 815     


Asp Ala Gly Val Ile Cys Ser Val Ser Gln Ser Arg Pro Thr Pro Ser 
            820                 825                 830         


Pro Asp Thr Trp Pro Thr Ser His Ala Ser Thr Ala Gly Pro Glu Ser 
        835                 840                 845             


Ser Leu Ala Leu Arg Leu Val Asn Gly Gly Asp Arg Cys Gln Gly Arg 
    850                 855                 860                 


Val Glu Val Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp Asp Ser 
865                 870                 875                 880 


Trp Asp Thr Ser Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly 
                885                 890                 895     


Trp Ala Thr Ser Ala Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly 
            900                 905                 910         


Pro Ile Val Leu Asp Asp Val Arg Cys Ser Gly Tyr Glu Ser Tyr Leu 
        915                 920                 925             


Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gln His Ser 
    930                 935                 940                 


Glu Asp Ala Gly Val Ile Cys Ser Ala Ala His Ser Trp Ser Thr Pro 
945                 950                 955                 960 


Ser Pro Asp Thr Leu Pro Thr Ile Thr Leu Pro Ala Ser Thr Val Gly 
                965                 970                 975     


Ser Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly Asp Arg Cys 
            980                 985                 990         


Gln Gly Arg Val Glu Val Leu Tyr  Gln Gly Ser Trp Gly  Thr Val Cys 
        995                 1000                 1005             


Asp Asp  Ser Trp Asp Thr Asn  Asp Ala Asn Val Val  Cys Arg Gln 
    1010                 1015                 1020             


Leu Gly  Cys Gly Trp Ala Met  Ser Ala Pro Gly Asn  Ala Arg Phe 
    1025                 1030                 1035             


Gly Gln  Gly Ser Gly Pro Ile  Val Leu Asp Asp Val  Arg Cys Ser 
    1040                 1045                 1050             


Gly His  Glu Ser Tyr Leu Trp  Ser Cys Pro His Asn  Gly Trp Leu 
    1055                 1060                 1065             


Ser His  Asn Cys Gly His Ser  Glu Asp Ala Gly Val  Ile Cys Ser 
    1070                 1075                 1080             


Ala Ser  Gln Ser Arg Pro Thr  Pro Ser Pro Asp Thr  Trp Pro Thr 
    1085                 1090                 1095             


Ser His  Ala Ser Thr Ala Gly  Ser Glu Ser Ser Leu  Ala Leu Arg 
    1100                 1105                 1110             


Leu Val  Asn Gly Gly Asp Arg  Cys Gln Gly Arg Val  Glu Val Leu 
    1115                 1120                 1125             


Tyr Arg  Gly Ser Trp Gly Thr  Val Cys Asp Asp Tyr  Trp Asp Thr 
    1130                 1135                 1140             


Asn Asp  Ala Asn Val Val Cys  Arg Gln Leu Gly Cys  Gly Trp Ala 
    1145                 1150                 1155             


Met Ser  Ala Pro Gly Asn Ala  Arg Phe Gly Gln Gly  Ser Gly Pro 
    1160                 1165                 1170             


Ile Val  Leu Asp Asp Val Arg  Cys Ser Gly His Glu  Ser Tyr Leu 
    1175                 1180                 1185             


Trp Ser  Cys Pro His Asn Gly  Trp Leu Ser His Asn  Cys Gly His 
    1190                 1195                 1200             


His Glu  Asp Ala Gly Val Ile  Cys Ser Ala Ser Gln  Ser Gln Pro 
    1205                 1210                 1215             


Thr Pro  Ser Pro Asp Thr Trp  Pro Thr Ser His Ala  Ser Thr Ala 
    1220                 1225                 1230             


Gly Ser  Glu Ser Ser Leu Ala  Leu Arg Leu Val Asn  Gly Gly Asp 
    1235                 1240                 1245             


Arg Cys  Gln Gly Arg Val Glu  Val Leu Tyr Arg Gly  Ser Trp Gly 
    1250                 1255                 1260             


Thr Val  Cys Asp Asp Tyr Trp  Asp Thr Asn Asp Ala  Asn Val Val 
    1265                 1270                 1275             


Cys Arg  Gln Leu Gly Cys Gly  Trp Ala Thr Ser Ala  Pro Gly Asn 
    1280                 1285                 1290             


Ala Arg  Phe Gly Gln Gly Ser  Gly Pro Ile Val Leu  Asp Asp Val 
    1295                 1300                 1305             


Arg Cys  Ser Gly His Glu Ser  Tyr Leu Trp Ser Cys  Pro His Asn 
    1310                 1315                 1320             


Gly Trp  Leu Ser His Asn Cys  Gly His His Glu Asp  Ala Gly Val 
    1325                 1330                 1335             


Ile Cys  Ser Ala Ser Gln Ser  Gln Pro Thr Pro Ser  Pro Asp Thr 
    1340                 1345                 1350             


Trp Pro  Thr Ser His Ala Ser  Thr Ala Gly Ser Glu  Ser Ser Leu 
    1355                 1360                 1365             


Ala Leu  Arg Leu Val Asn Gly  Gly Asp Arg Cys Gln  Gly Arg Val 
    1370                 1375                 1380             


Glu Val  Leu Tyr Arg Gly Ser  Trp Gly Thr Val Cys  Asp Asp Tyr 
    1385                 1390                 1395             


Trp Asp  Thr Asn Asp Ala Asn  Val Val Cys Arg Gln  Leu Gly Cys 
    1400                 1405                 1410             


Gly Trp  Ala Thr Ser Ala Pro  Gly Asn Ala Arg Phe  Gly Gln Gly 
    1415                 1420                 1425             


Ser Gly  Pro Ile Val Leu Asp  Asp Val Arg Cys Ser  Gly His Glu 
    1430                 1435                 1440             


Ser Tyr  Leu Trp Ser Cys Pro  His Asn Gly Trp Leu  Ser His Asn 
    1445                 1450                 1455             


Cys Gly  His His Glu Asp Ala  Gly Val Ile Cys Ser  Ala Ser Gln 
    1460                 1465                 1470             


Ser Gln  Pro Thr Pro Ser Pro  Asp Thr Trp Pro Thr  Ser Arg Ala 
    1475                 1480                 1485             


Ser Thr  Ala Gly Ser Glu Ser  Thr Leu Ala Leu Arg  Leu Val Asn 
    1490                 1495                 1500             


Gly Gly  Asp Arg Cys Arg Gly  Arg Val Glu Val Leu  Tyr Gln Gly 
    1505                 1510                 1515             


Ser Trp  Gly Thr Val Cys Asp  Asp Tyr Trp Asp Thr  Asn Asp Ala 
    1520                 1525                 1530             


Asn Val  Val Cys Arg Gln Leu  Gly Cys Gly Trp Ala  Met Ser Ala 
    1535                 1540                 1545             


Pro Gly  Asn Ala Gln Phe Gly  Gln Gly Ser Gly Pro  Ile Val Leu 
    1550                 1555                 1560             


Asp Asp  Val Arg Cys Ser Gly  His Glu Ser Tyr Leu  Trp Ser Cys 
    1565                 1570                 1575             


Pro His  Asn Gly Trp Leu Ser  His Asn Cys Gly His  His Glu Asp 
    1580                 1585                 1590             


Ala Gly  Val Ile Cys Ser Ala  Ala Gln Ser Gln Ser  Thr Pro Arg 
    1595                 1600                 1605             


Pro Asp  Thr Trp Leu Thr Thr  Asn Leu Pro Ala Leu  Thr Val Gly 
    1610                 1615                 1620             


Ser Glu  Ser Ser Leu Ala Leu  Arg Leu Val Asn Gly  Gly Asp Arg 
    1625                 1630                 1635             


Cys Arg  Gly Arg Val Glu Val  Leu Tyr Arg Gly Ser  Trp Gly Thr 
    1640                 1645                 1650             


Val Cys  Asp Asp Ser Trp Asp  Thr Asn Asp Ala Asn  Val Val Cys 
    1655                 1660                 1665             


Arg Gln  Leu Gly Cys Gly Trp  Ala Met Ser Ala Pro  Gly Asn Ala 
    1670                 1675                 1680             


Arg Phe  Gly Gln Gly Ser Gly  Pro Ile Val Leu Asp  Asp Val Arg 
    1685                 1690                 1695             


Cys Ser  Gly Asn Glu Ser Tyr  Leu Trp Ser Cys Pro  His Lys Gly 
    1700                 1705                 1710             


Trp Leu  Thr His Asn Cys Gly  His His Glu Asp Ala  Gly Val Ile 
    1715                 1720                 1725             


Cys Ser  Ala Thr Gln Ile Asn  Ser Thr Thr Thr Asp  Trp Trp His 
    1730                 1735                 1740             


Pro Thr  Thr Thr Thr Thr Ala  Arg Pro Ser Ser Asn  Cys Gly Gly 
    1745                 1750                 1755             


Phe Leu  Phe Tyr Ala Ser Gly  Thr Phe Ser Ser Pro  Ser Tyr Pro 
    1760                 1765                 1770             


Ala Tyr  Tyr Pro Asn Asn Ala  Lys Cys Val Trp Glu  Ile Glu Val 
    1775                 1780                 1785             


Asn Ser  Gly Tyr Arg Ile Asn  Leu Gly Phe Ser Asn  Leu Lys Leu 
    1790                 1795                 1800             


Glu Ala  His His Asn Cys Ser  Phe Asp Tyr Val Glu  Ile Phe Asp 
    1805                 1810                 1815             


Gly Ser  Leu Asn Ser Ser Leu  Leu Leu Gly Lys Ile  Cys Asn Asp 
    1820                 1825                 1830             


Thr Arg  Gln Ile Phe Thr Ser  Ser Tyr Asn Arg Met  Thr Ile His 
    1835                 1840                 1845             


Phe Arg  Ser Asp Ile Ser Phe  Gln Asn Thr Gly Phe  Leu Ala Trp 
    1850                 1855                 1860             


Tyr Asn  Ser Phe Pro Ser Asp  Ala Thr Leu Arg Leu  Val Asn Leu 
    1865                 1870                 1875             


Asn Ser  Ser Tyr Gly Leu Cys  Ala Gly Arg Val Glu  Ile Tyr His 
    1880                 1885                 1890             


Gly Gly  Thr Trp Gly Thr Val  Cys Asp Asp Ser Trp  Thr Ile Gln 
    1895                 1900                 1905             


Glu Ala  Glu Val Val Cys Arg  Gln Leu Gly Cys Gly  Arg Ala Val 
    1910                 1915                 1920             


Ser Ala  Leu Gly Asn Ala Tyr  Phe Gly Ser Gly Ser  Gly Pro Ile 
    1925                 1930                 1935             


Thr Leu  Asp Asp Val Glu Cys  Ser Gly Thr Glu Ser  Thr Leu Trp 
    1940                 1945                 1950             


Gln Cys  Arg Asn Arg Gly Trp  Phe Ser His Asn Cys  Asn His Arg 
    1955                 1960                 1965             


Glu Asp  Ala Gly Val Ile Cys  Ser Gly Asn His Leu  Ser Thr Pro 
    1970                 1975                 1980             


Ala Pro  Phe Leu Asn Ile Thr  Arg Pro Asn Thr Asp  Tyr Ser Cys 
    1985                 1990                 1995             


Gly Gly  Phe Leu Ser Gln Pro  Ser Gly Asp Phe Ser  Ser Pro Phe 
    2000                 2005                 2010             


Tyr Pro  Gly Asn Tyr Pro Asn  Asn Ala Lys Cys Val  Trp Asp Ile 
    2015                 2020                 2025             


Glu Val  Gln Asn Asn Tyr Arg  Val Thr Val Ile Phe  Arg Asp Val 
    2030                 2035                 2040             


Gln Leu  Glu Gly Gly Cys Asn  Tyr Asp Tyr Ile Glu  Val Phe Asp 
    2045                 2050                 2055             


Gly Pro  Tyr Arg Ser Ser Pro  Leu Ile Ala Arg Val  Cys Asp Gly 
    2060                 2065                 2070             


Ala Arg  Gly Ser Phe Thr Ser  Ser Ser Asn Phe Met  Ser Ile Arg 
    2075                 2080                 2085             


Phe Ile  Ser Asp His Ser Ile  Thr Arg Arg Gly Phe  Arg Ala Glu 
    2090                 2095                 2100             


Tyr Tyr  Ser Ser Pro Ser Asn  Asp Ser Thr Asn Leu  Leu Cys Leu 
    2105                 2110                 2115             


Pro Asn  His Met Gln Ala Ser  Val Ser Arg Ser Tyr  Leu Gln Ser 
    2120                 2125                 2130             


Leu Gly  Phe Ser Ala Ser Asp  Leu Val Ile Ser Thr  Trp Asn Gly 
    2135                 2140                 2145             


Tyr Tyr  Glu Cys Arg Pro Gln  Ile Thr Pro Asn Leu  Val Ile Phe 
    2150                 2155                 2160             


Thr Ile  Pro Tyr Ser Gly Cys  Gly Thr Phe Lys Gln  Ala Asp Asn 
    2165                 2170                 2175             


Asp Thr  Ile Asp Tyr Ser Asn  Phe Leu Thr Ala Ala  Val Ser Gly 
    2180                 2185                 2190             


Gly Ile  Ile Lys Arg Arg Thr  Asp Leu Arg Ile His  Val Ser Cys 
    2195                 2200                 2205             


Arg Met  Leu Gln Asn Thr Trp  Val Asp Thr Met Tyr  Ile Ala Asn 
    2210                 2215                 2220             


Asp Thr  Ile His Val Ala Asn  Asn Thr Ile Gln Val  Glu Glu Val 
    2225                 2230                 2235             


Gln Tyr  Gly Asn Phe Asp Val  Asn Ile Ser Phe Tyr  Thr Ser Ser 
    2240                 2245                 2250             


Ser Phe  Leu Tyr Pro Val Thr  Ser Arg Pro Tyr Tyr  Val Asp Leu 
    2255                 2260                 2265             


Asn Gln  Asp Leu Tyr Val Gln  Ala Glu Ile Leu His  Ser Asp Ala 
    2270                 2275                 2280             


Val Leu  Thr Leu Phe Val Asp  Thr Cys Val Ala Ser  Pro Tyr Ser 
    2285                 2290                 2295             


Asn Asp  Phe Thr Ser Leu Thr  Tyr Asp Leu Ile Arg  Ser Gly Cys 
    2300                 2305                 2310             


Val Arg  Asp Asp Thr Tyr Gly  Pro Tyr Ser Ser Pro  Ser Leu Arg 
    2315                 2320                 2325             


Ile Ala  Arg Phe Arg Phe Arg  Ala Phe His Phe Leu  Asn Arg Phe 
    2330                 2335                 2340             


Pro Ser  Val Tyr Leu Arg Cys  Lys Met Val Val Cys  Arg Ala Tyr 
    2345                 2350                 2355             


Asp Pro  Ser Ser Arg Cys Tyr  Arg Gly Cys Val Leu  Arg Ser Lys 
    2360                 2365                 2370             


Arg Asp  Val Gly Ser Tyr Gln  Glu Lys Val Asp Val  Val Leu Gly 
    2375                 2380                 2385             


Pro Ile  Gln Leu Gln Thr Pro  Pro Arg Arg Glu Glu  Glu Pro Arg 
    2390                 2395                 2400             


<210>  4286
<211>  2542
<212>  PRT
<213>  Homo Sapiens

<400>  4286

Met Gly Ile Ser Thr Val Ile Leu Glu Met Cys Leu Leu Trp Gly Gln 
1               5                   10                  15      


Val Leu Ser Thr Gly Gly Trp Ile Pro Arg Thr Thr Asp Tyr Ala Ser 
            20                  25                  30          


Leu Ile Pro Ser Glu Val Pro Leu Asp Pro Thr Val Ala Glu Gly Ser 
        35                  40                  45              


Pro Phe Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
    50                  55                  60                  


Pro Ile Ser Leu Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
65                  70                  75                  80  


Leu Ile Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
                85                  90                  95      


Asp Ser Gly Leu Ala Leu Arg Leu Val Asn Gly Asp Gly Arg Cys Gln 
            100                 105                 110         


Gly Arg Val Glu Ile Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp 
        115                 120                 125             


Asp Ser Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly 
    130                 135                 140                 


Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Trp Phe Gly Gln Gly 
145                 150                 155                 160 


Ser Gly Pro Ile Ala Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser 
                165                 170                 175     


Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly 
            180                 185                 190         


His Gly Glu Asp Ala Gly Val Ile Cys Ser Ala Ala Gln Pro Gln Ser 
        195                 200                 205             


Thr Leu Arg Pro Glu Ser Trp Pro Val Arg Ile Ser Pro Pro Val Pro 
    210                 215                 220                 


Thr Glu Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly 
225                 230                 235                 240 


Asp Arg Cys Arg Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp Gly 
                245                 250                 255     


Thr Val Cys Asp Asp Tyr Trp Asp Thr Asn Asp Ala Asn Val Val Cys 
            260                 265                 270         


Arg Gln Leu Gly Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Gln 
        275                 280                 285             


Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser 
    290                 295                 300                 


Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Thr 
305                 310                 315                 320 


His Asn Cys Gly His Ser Glu Asp Ala Gly Val Ile Cys Ser Ala Pro 
                325                 330                 335     


Gln Ser Arg Pro Thr Pro Ser Pro Asp Thr Trp Pro Thr Ser His Ala 
            340                 345                 350         


Ser Thr Ala Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly 
        355                 360                 365             


Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp 
    370                 375                 380                 


Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Ser Asp Ala Asn Val Val 
385                 390                 395                 400 


Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly Asn Ala 
                405                 410                 415     


Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys 
            420                 425                 430         


Ser Gly Tyr Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu 
        435                 440                 445             


Ser His Asn Cys Gln His Ser Glu Asp Ala Gly Val Ile Cys Ser Ala 
    450                 455                 460                 


Ala His Ser Trp Ser Thr Pro Ser Pro Asp Thr Leu Pro Thr Ile Thr 
465                 470                 475                 480 


Leu Pro Ala Ser Thr Val Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu 
                485                 490                 495     


Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg 
            500                 505                 510         


Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Asn Asp Ala 
        515                 520                 525             


Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Met Leu Ala Pro 
    530                 535                 540                 


Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp 
545                 550                 555                 560 


Val Arg Cys Ser Gly Asn Glu Ser Tyr Leu Trp Ser Cys Pro His Asn 
                565                 570                 575     


Gly Trp Leu Ser His Asn Cys Gly His Ser Glu Asp Ala Gly Val Ile 
            580                 585                 590         


Cys Ser Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly 
        595                 600                 605             


Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp Gly 
    610                 615                 620                 


Thr Val Cys Asp Asp Ser Trp Asp Thr Asn Asp Ala Asn Val Val Cys 
625                 630                 635                 640 


Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly Asn Ala Arg 
                645                 650                 655     


Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser 
            660                 665                 670         


Gly His Glu Ser Tyr Leu Trp Ser Cys Pro Asn Asn Gly Trp Leu Ser 
        675                 680                 685             


His Asn Cys Gly His His Glu Asp Ala Gly Val Ile Cys Ser Ala Ala 
    690                 695                 700                 


Gln Ser Arg Ser Thr Pro Arg Pro Asp Thr Leu Ser Thr Ile Thr Leu 
705                 710                 715                 720 


Pro Pro Ser Thr Val Gly Ser Glu Ser Ser Leu Thr Leu Arg Leu Val 
                725                 730                 735     


Asn Gly Ser Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly 
            740                 745                 750         


Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Asn Asp Ala Asn 
        755                 760                 765             


Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly 
    770                 775                 780                 


Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val 
785                 790                 795                 800 


Arg Cys Ser Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly 
                805                 810                 815     


Trp Leu Ser His Asn Cys Gly His His Glu Asp Ala Gly Val Ile Cys 
            820                 825                 830         


Ser Val Ser Gln Ser Arg Pro Thr Pro Ser Pro Asp Thr Trp Pro Thr 
        835                 840                 845             


Ser His Ala Ser Thr Ala Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu 
    850                 855                 860                 


Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg 
865                 870                 875                 880 


Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Ser Asp Ala 
                885                 890                 895     


Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro 
            900                 905                 910         


Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp 
        915                 920                 925             


Val Arg Cys Ser Gly Tyr Glu Ser Tyr Leu Trp Ser Cys Pro His Asn 
    930                 935                 940                 


Gly Trp Leu Ser His Asn Cys Gln His Ser Glu Asp Ala Gly Val Ile 
945                 950                 955                 960 


Cys Ser Ala Ala His Ser Trp Ser Thr Pro Ser Pro Asp Thr Leu Pro 
                965                 970                 975     


Thr Ile Thr Leu Pro Ala Ser Thr Val Gly Ser Glu Ser Ser Leu Ala 
            980                 985                 990         


Leu Arg Leu Val Asn Gly Gly Asp  Arg Cys Gln Gly Arg  Val Glu Val 
        995                 1000                 1005             


Leu Tyr  Gln Gly Ser Trp Gly  Thr Val Cys Asp Asp  Ser Trp Asp 
    1010                 1015                 1020             


Thr Asn  Asp Ala Asn Val Val  Cys Arg Gln Leu Gly  Cys Gly Trp 
    1025                 1030                 1035             


Ala Met  Ser Ala Pro Gly Asn  Ala Arg Phe Gly Gln  Gly Ser Gly 
    1040                 1045                 1050             


Pro Ile  Val Leu Asp Asp Val  Arg Cys Ser Gly His  Glu Ser Tyr 
    1055                 1060                 1065             


Leu Trp  Ser Cys Pro His Asn  Gly Trp Leu Ser His  Asn Cys Gly 
    1070                 1075                 1080             


His Ser  Glu Asp Ala Gly Val  Ile Cys Ser Ala Ser  Gln Ser Arg 
    1085                 1090                 1095             


Pro Thr  Pro Ser Pro Asp Thr  Trp Pro Thr Ser His  Ala Ser Thr 
    1100                 1105                 1110             


Ala Gly  Ser Glu Ser Ser Leu  Ala Leu Arg Leu Val  Asn Gly Gly 
    1115                 1120                 1125             


Asp Arg  Cys Gln Gly Arg Val  Glu Val Leu Tyr Arg  Gly Ser Trp 
    1130                 1135                 1140             


Gly Thr  Val Cys Asp Asp Tyr  Trp Asp Thr Asn Asp  Ala Asn Val 
    1145                 1150                 1155             


Val Cys  Arg Gln Leu Gly Cys  Gly Trp Ala Met Ser  Ala Pro Gly 
    1160                 1165                 1170             


Asn Ala  Arg Phe Gly Gln Gly  Ser Gly Pro Ile Val  Leu Asp Asp 
    1175                 1180                 1185             


Val Arg  Cys Ser Gly His Glu  Ser Tyr Leu Trp Ser  Cys Pro His 
    1190                 1195                 1200             


Asn Gly  Trp Leu Ser His Asn  Cys Gly His His Glu  Asp Ala Gly 
    1205                 1210                 1215             


Val Ile  Cys Ser Ala Ser Gln  Ser Gln Pro Thr Pro  Ser Pro Asp 
    1220                 1225                 1230             


Thr Trp  Pro Thr Ser His Ala  Ser Thr Ala Gly Ser  Glu Ser Ser 
    1235                 1240                 1245             


Leu Ala  Leu Arg Leu Val Asn  Gly Gly Asp Arg Cys  Gln Gly Arg 
    1250                 1255                 1260             


Val Glu  Val Leu Tyr Arg Gly  Ser Trp Gly Thr Val  Cys Asp Asp 
    1265                 1270                 1275             


Tyr Trp  Asp Thr Asn Asp Ala  Asn Val Val Cys Arg  Gln Leu Gly 
    1280                 1285                 1290             


Cys Gly  Trp Ala Thr Ser Ala  Pro Gly Asn Ala Arg  Phe Gly Gln 
    1295                 1300                 1305             


Gly Ser  Gly Pro Ile Val Leu  Asp Asp Val Arg Cys  Ser Gly His 
    1310                 1315                 1320             


Glu Ser  Tyr Leu Trp Ser Cys  Pro His Asn Gly Trp  Leu Ser His 
    1325                 1330                 1335             


Asn Cys  Gly His His Glu Asp  Ala Gly Val Ile Cys  Ser Ala Ser 
    1340                 1345                 1350             


Gln Ser  Gln Pro Thr Pro Ser  Pro Asp Thr Trp Pro  Thr Ser His 
    1355                 1360                 1365             


Ala Ser  Thr Ala Gly Ser Glu  Ser Ser Leu Ala Leu  Arg Leu Val 
    1370                 1375                 1380             


Asn Gly  Gly Asp Arg Cys Gln  Gly Arg Val Glu Val  Leu Tyr Arg 
    1385                 1390                 1395             


Gly Ser  Trp Gly Thr Val Cys  Asp Asp Tyr Trp Asp  Thr Asn Asp 
    1400                 1405                 1410             


Ala Asn  Val Val Cys Arg Gln  Leu Gly Cys Gly Trp  Ala Thr Ser 
    1415                 1420                 1425             


Ala Pro  Gly Asn Ala Arg Phe  Gly Gln Gly Ser Gly  Pro Ile Val 
    1430                 1435                 1440             


Leu Asp  Asp Val Arg Cys Ser  Gly His Glu Ser Tyr  Leu Trp Ser 
    1445                 1450                 1455             


Cys Pro  His Asn Gly Trp Leu  Ser His Asn Cys Gly  His His Glu 
    1460                 1465                 1470             


Asp Ala  Gly Val Ile Cys Ser  Ala Ser Gln Ser Gln  Pro Thr Pro 
    1475                 1480                 1485             


Ser Pro  Asp Thr Trp Pro Thr  Ser His Ala Ser Thr  Ala Gly Ser 
    1490                 1495                 1500             


Glu Ser  Ser Leu Ala Leu Arg  Leu Val Asn Gly Gly  Asp Arg Cys 
    1505                 1510                 1515             


Gln Gly  Arg Val Glu Val Leu  Tyr Arg Gly Ser Trp  Gly Thr Val 
    1520                 1525                 1530             


Cys Asp  Asp Tyr Trp Asp Thr  Asn Asp Ala Asn Val  Val Cys Arg 
    1535                 1540                 1545             


Gln Leu  Gly Cys Gly Trp Ala  Thr Ser Ala Pro Gly  Asn Ala Arg 
    1550                 1555                 1560             


Phe Gly  Gln Gly Ser Gly Pro  Ile Val Leu Asp Asp  Val Arg Cys 
    1565                 1570                 1575             


Ser Gly  His Glu Ser Tyr Leu  Trp Ser Cys Pro His  Asn Gly Trp 
    1580                 1585                 1590             


Leu Ser  His Asn Cys Gly His  His Glu Asp Ala Gly  Val Ile Cys 
    1595                 1600                 1605             


Ser Ala  Ser Gln Ser Gln Pro  Thr Pro Ser Pro Asp  Thr Trp Pro 
    1610                 1615                 1620             


Thr Ser  Arg Ala Ser Thr Ala  Gly Ser Glu Ser Thr  Leu Ala Leu 
    1625                 1630                 1635             


Arg Leu  Val Asn Gly Gly Asp  Arg Cys Arg Gly Arg  Val Glu Val 
    1640                 1645                 1650             


Leu Tyr  Gln Gly Ser Trp Gly  Thr Val Cys Asp Asp  Tyr Trp Asp 
    1655                 1660                 1665             


Thr Asn  Asp Ala Asn Val Val  Cys Arg Gln Leu Gly  Cys Gly Trp 
    1670                 1675                 1680             


Ala Met  Ser Ala Pro Gly Asn  Ala Gln Phe Gly Gln  Gly Ser Gly 
    1685                 1690                 1695             


Pro Ile  Val Leu Asp Asp Val  Arg Cys Ser Gly His  Glu Ser Tyr 
    1700                 1705                 1710             


Leu Trp  Ser Cys Pro His Asn  Gly Trp Leu Ser His  Asn Cys Gly 
    1715                 1720                 1725             


His His  Glu Asp Ala Gly Val  Ile Cys Ser Ala Ala  Gln Ser Gln 
    1730                 1735                 1740             


Ser Thr  Pro Arg Pro Asp Thr  Trp Leu Thr Thr Asn  Leu Pro Ala 
    1745                 1750                 1755             


Leu Thr  Val Gly Ser Glu Ser  Ser Leu Ala Leu Arg  Leu Val Asn 
    1760                 1765                 1770             


Gly Gly  Asp Arg Cys Arg Gly  Arg Val Glu Val Leu  Tyr Arg Gly 
    1775                 1780                 1785             


Ser Trp  Gly Thr Val Cys Asp  Asp Ser Trp Asp Thr  Asn Asp Ala 
    1790                 1795                 1800             


Asn Val  Val Cys Arg Gln Leu  Gly Cys Gly Trp Ala  Met Ser Ala 
    1805                 1810                 1815             


Pro Gly  Asn Ala Arg Phe Gly  Gln Gly Ser Gly Pro  Ile Val Leu 
    1820                 1825                 1830             


Asp Asp  Val Arg Cys Ser Gly  Asn Glu Ser Tyr Leu  Trp Ser Cys 
    1835                 1840                 1845             


Pro His  Lys Gly Trp Leu Thr  His Asn Cys Gly His  His Glu Asp 
    1850                 1855                 1860             


Ala Gly  Val Ile Cys Ser Ala  Thr Gln Ile Asn Ser  Thr Thr Thr 
    1865                 1870                 1875             


Asp Trp  Trp His Pro Thr Thr  Thr Thr Thr Ala Arg  Pro Ser Ser 
    1880                 1885                 1890             


Asn Cys  Gly Gly Phe Leu Phe  Tyr Ala Ser Gly Thr  Phe Ser Ser 
    1895                 1900                 1905             


Pro Ser  Tyr Pro Ala Tyr Tyr  Pro Asn Asn Ala Lys  Cys Val Trp 
    1910                 1915                 1920             


Glu Ile  Glu Val Asn Ser Gly  Tyr Arg Ile Asn Leu  Gly Phe Ser 
    1925                 1930                 1935             


Asn Leu  Lys Leu Glu Ala His  His Asn Cys Ser Phe  Asp Tyr Val 
    1940                 1945                 1950             


Glu Ile  Phe Asp Gly Ser Leu  Asn Ser Ser Leu Leu  Leu Gly Lys 
    1955                 1960                 1965             


Ile Cys  Asn Asp Thr Arg Gln  Ile Phe Thr Ser Ser  Tyr Asn Arg 
    1970                 1975                 1980             


Met Thr  Ile His Phe Arg Ser  Asp Ile Ser Phe Gln  Asn Thr Gly 
    1985                 1990                 1995             


Phe Leu  Ala Trp Tyr Asn Ser  Phe Pro Ser Asp Ala  Thr Leu Arg 
    2000                 2005                 2010             


Leu Val  Asn Leu Asn Ser Ser  Tyr Gly Leu Cys Ala  Gly Arg Val 
    2015                 2020                 2025             


Glu Ile  Tyr His Gly Gly Thr  Trp Gly Thr Val Cys  Asp Asp Ser 
    2030                 2035                 2040             


Trp Thr  Ile Gln Glu Ala Glu  Val Val Cys Arg Gln  Leu Gly Cys 
    2045                 2050                 2055             


Gly Arg  Ala Val Ser Ala Leu  Gly Asn Ala Tyr Phe  Gly Ser Gly 
    2060                 2065                 2070             


Ser Gly  Pro Ile Thr Leu Asp  Asp Val Glu Cys Ser  Gly Thr Glu 
    2075                 2080                 2085             


Ser Thr  Leu Trp Gln Cys Arg  Asn Arg Gly Trp Phe  Ser His Asn 
    2090                 2095                 2100             


Cys Asn  His Arg Glu Asp Ala  Gly Val Ile Cys Ser  Gly Asn His 
    2105                 2110                 2115             


Leu Ser  Thr Pro Ala Pro Phe  Leu Asn Ile Thr Arg  Pro Asn Thr 
    2120                 2125                 2130             


Asp Tyr  Ser Cys Gly Gly Phe  Leu Ser Gln Pro Ser  Gly Asp Phe 
    2135                 2140                 2145             


Ser Ser  Pro Phe Tyr Pro Gly  Asn Tyr Pro Asn Asn  Ala Lys Cys 
    2150                 2155                 2160             


Val Trp  Asp Ile Glu Val Gln  Asn Asn Tyr Arg Val  Thr Val Ile 
    2165                 2170                 2175             


Phe Arg  Asp Val Gln Leu Glu  Gly Gly Cys Asn Tyr  Asp Tyr Ile 
    2180                 2185                 2190             


Glu Val  Phe Asp Gly Pro Tyr  Arg Ser Ser Pro Leu  Ile Ala Arg 
    2195                 2200                 2205             


Val Cys  Asp Gly Ala Arg Gly  Ser Phe Thr Ser Ser  Ser Asn Phe 
    2210                 2215                 2220             


Met Ser  Ile Arg Phe Ile Ser  Asp His Ser Ile Thr  Arg Arg Gly 
    2225                 2230                 2235             


Phe Arg  Ala Glu Tyr Tyr Ser  Ser Pro Ser Asn Asp  Ser Thr Asn 
    2240                 2245                 2250             


Leu Leu  Cys Leu Pro Asn His  Met Gln Ala Ser Val  Ser Arg Ser 
    2255                 2260                 2265             


Tyr Leu  Gln Ser Leu Gly Phe  Ser Ala Ser Asp Leu  Val Ile Ser 
    2270                 2275                 2280             


Thr Trp  Asn Gly Tyr Tyr Glu  Cys Arg Pro Gln Ile  Thr Pro Asn 
    2285                 2290                 2295             


Leu Val  Ile Phe Thr Ile Pro  Tyr Ser Gly Cys Gly  Thr Phe Lys 
    2300                 2305                 2310             


Gln Ala  Asp Asn Asp Thr Ile  Asp Tyr Ser Asn Phe  Leu Thr Ala 
    2315                 2320                 2325             


Ala Val  Ser Gly Gly Ile Ile  Lys Arg Arg Thr Asp  Leu Arg Ile 
    2330                 2335                 2340             


His Val  Ser Cys Arg Met Leu  Gln Asn Thr Trp Val  Asp Thr Met 
    2345                 2350                 2355             


Tyr Ile  Ala Asn Asp Thr Ile  His Val Ala Asn Asn  Thr Ile Gln 
    2360                 2365                 2370             


Val Glu  Glu Val Gln Tyr Gly  Asn Phe Asp Val Asn  Ile Ser Phe 
    2375                 2380                 2385             


Tyr Thr  Ser Ser Ser Phe Leu  Tyr Pro Val Thr Ser  Arg Pro Tyr 
    2390                 2395                 2400             


Tyr Val  Asp Leu Asn Gln Asp  Leu Tyr Val Gln Ala  Glu Ile Leu 
    2405                 2410                 2415             


His Ser  Asp Ala Val Leu Thr  Leu Phe Val Asp Thr  Cys Val Ala 
    2420                 2425                 2430             


Ser Pro  Tyr Ser Asn Asp Phe  Thr Ser Leu Thr Tyr  Asp Leu Ile 
    2435                 2440                 2445             


Arg Ser  Gly Cys Val Arg Asp  Asp Thr Tyr Gly Pro  Tyr Ser Ser 
    2450                 2455                 2460             


Pro Ser  Leu Arg Ile Ala Arg  Phe Arg Phe Arg Ala  Phe His Phe 
    2465                 2470                 2475             


Leu Asn  Arg Phe Pro Ser Val  Tyr Leu Arg Cys Lys  Met Val Val 
    2480                 2485                 2490             


Cys Arg  Ala Tyr Asp Pro Ser  Ser Arg Cys Tyr Arg  Gly Cys Val 
    2495                 2500                 2505             


Leu Arg  Ser Lys Arg Asp Val  Gly Ser Tyr Gln Glu  Lys Val Asp 
    2510                 2515                 2520             


Val Val  Leu Gly Pro Ile Gln  Leu Gln Thr Pro Pro  Arg Arg Glu 
    2525                 2530                 2535             


Glu Glu  Pro Arg 
    2540         


<210>  4287
<211>  1785
<212>  PRT
<213>  Homo Sapiens

<400>  4287

Met Gly Ile Ser Thr Val Ile Leu Glu Met Cys Leu Leu Trp Gly Gln 
1               5                   10                  15      


Val Leu Ser Thr Gly Gly Trp Ile Pro Arg Thr Thr Asp Tyr Ala Ser 
            20                  25                  30          


Leu Ile Pro Ser Glu Val Pro Leu Asp Pro Thr Val Ala Glu Gly Ser 
        35                  40                  45              


Pro Phe Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
    50                  55                  60                  


Pro Ile Ser Leu Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
65                  70                  75                  80  


Leu Ile Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
                85                  90                  95      


Asp Ser Gly Leu Ala Leu Arg Leu Val Asn Gly Asp Gly Arg Cys Gln 
            100                 105                 110         


Gly Arg Val Glu Ile Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp 
        115                 120                 125             


Asp Ser Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly 
    130                 135                 140                 


Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Trp Phe Gly Gln Gly 
145                 150                 155                 160 


Ser Gly Pro Ile Ala Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser 
                165                 170                 175     


Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly 
            180                 185                 190         


His Gly Glu Asp Ala Gly Val Ile Cys Ser Ala Ala Gln Pro Gln Ser 
        195                 200                 205             


Thr Leu Arg Pro Glu Ser Trp Pro Val Arg Ile Ser Pro Pro Val Pro 
    210                 215                 220                 


Thr Glu Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly 
225                 230                 235                 240 


Asp Arg Cys Arg Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp Gly 
                245                 250                 255     


Thr Val Cys Asp Asp Tyr Trp Asp Thr Asn Asp Ala Asn Val Val Cys 
            260                 265                 270         


Arg Gln Leu Gly Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Gln 
        275                 280                 285             


Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser 
    290                 295                 300                 


Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Thr 
305                 310                 315                 320 


His Asn Cys Gly His Ser Glu Asp Ala Gly Val Ile Cys Ser Ala Pro 
                325                 330                 335     


Gln Ser Arg Pro Thr Pro Ser Pro Asp Thr Trp Pro Thr Ser His Ala 
            340                 345                 350         


Ser Thr Ala Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly 
        355                 360                 365             


Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp 
    370                 375                 380                 


Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Ser Asp Ala Asn Val Val 
385                 390                 395                 400 


Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly Asn Ala 
                405                 410                 415     


Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys 
            420                 425                 430         


Ser Gly Tyr Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu 
        435                 440                 445             


Ser His Asn Cys Gln His Ser Glu Asp Ala Gly Val Ile Cys Ser Ala 
    450                 455                 460                 


Ala His Ser Trp Ser Thr Pro Ser Pro Asp Thr Leu Pro Thr Ile Thr 
465                 470                 475                 480 


Leu Pro Ala Ser Thr Val Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu 
                485                 490                 495     


Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Gln 
            500                 505                 510         


Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Asn Asp Ala 
        515                 520                 525             


Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Met Ser Ala Pro 
    530                 535                 540                 


Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp 
545                 550                 555                 560 


Val Arg Cys Ser Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His Asn 
                565                 570                 575     


Gly Trp Leu Ser His Asn Cys Gly His Ser Glu Asp Ala Gly Val Ile 
            580                 585                 590         


Cys Ser Ala Ser Gln Ser Arg Pro Thr Pro Ser Pro Asp Thr Trp Pro 
        595                 600                 605             


Thr Ser His Ala Ser Thr Ala Gly Ser Glu Ser Ser Leu Ala Leu Arg 
    610                 615                 620                 


Leu Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr 
625                 630                 635                 640 


Arg Gly Ser Trp Gly Thr Val Cys Asp Asp Tyr Trp Asp Thr Asn Asp 
                645                 650                 655     


Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Met Ser Ala 
            660                 665                 670         


Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp 
        675                 680                 685             


Asp Val Arg Cys Ser Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His 
    690                 695                 700                 


Asn Gly Trp Leu Ser His Asn Cys Gly His His Glu Asp Ala Gly Val 
705                 710                 715                 720 


Ile Cys Ser Ala Ser Gln Ser Gln Pro Thr Pro Ser Pro Asp Thr Trp 
                725                 730                 735     


Pro Thr Ser His Ala Ser Thr Ala Gly Ser Glu Ser Ser Leu Ala Leu 
            740                 745                 750         


Arg Leu Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu 
        755                 760                 765             


Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp Asp Tyr Trp Asp Thr Asn 
    770                 775                 780                 


Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser 
785                 790                 795                 800 


Ala Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu 
                805                 810                 815     


Asp Asp Val Arg Cys Ser Gly His Glu Ser Tyr Leu Trp Ser Cys Pro 
            820                 825                 830         


His Asn Gly Trp Leu Ser His Asn Cys Gly His His Glu Asp Ala Gly 
        835                 840                 845             


Val Ile Cys Ser Ala Ser Gln Ser Gln Pro Thr Pro Ser Pro Asp Thr 
    850                 855                 860                 


Trp Pro Thr Ser Arg Ala Ser Thr Ala Gly Ser Glu Ser Thr Leu Ala 
865                 870                 875                 880 


Leu Arg Leu Val Asn Gly Gly Asp Arg Cys Arg Gly Arg Val Glu Val 
                885                 890                 895     


Leu Tyr Gln Gly Ser Trp Gly Thr Val Cys Asp Asp Tyr Trp Asp Thr 
            900                 905                 910         


Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Met 
        915                 920                 925             


Ser Ala Pro Gly Asn Ala Gln Phe Gly Gln Gly Ser Gly Pro Ile Val 
    930                 935                 940                 


Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser Tyr Leu Trp Ser Cys 
945                 950                 955                 960 


Pro His Asn Gly Trp Leu Ser His Asn Cys Gly His His Glu Asp Ala 
                965                 970                 975     


Gly Val Ile Cys Ser Ala Ala Gln Ser Gln Ser Thr Pro Arg Pro Asp 
            980                 985                 990         


Thr Trp Leu Thr Thr Asn Leu Pro  Ala Leu Thr Val Gly  Ser Glu Ser 
        995                 1000                 1005             


Ser Leu  Ala Leu Arg Leu Val  Asn Gly Gly Asp Arg  Cys Arg Gly 
    1010                 1015                 1020             


Arg Val  Glu Val Leu Tyr Arg  Gly Ser Trp Gly Thr  Val Cys Asp 
    1025                 1030                 1035             


Asp Ser  Trp Asp Thr Asn Asp  Ala Asn Val Val Cys  Arg Gln Leu 
    1040                 1045                 1050             


Gly Cys  Gly Trp Ala Met Ser  Ala Pro Gly Asn Ala  Arg Phe Gly 
    1055                 1060                 1065             


Gln Gly  Ser Gly Pro Ile Val  Leu Asp Asp Val Arg  Cys Ser Gly 
    1070                 1075                 1080             


Asn Glu  Ser Tyr Leu Trp Ser  Cys Pro His Lys Gly  Trp Leu Thr 
    1085                 1090                 1095             


His Asn  Cys Gly His His Glu  Asp Ala Gly Val Ile  Cys Ser Ala 
    1100                 1105                 1110             


Thr Gln  Ile Asn Ser Thr Thr  Thr Asp Trp Trp His  Pro Thr Thr 
    1115                 1120                 1125             


Thr Thr  Thr Ala Arg Pro Ser  Ser Asn Cys Gly Gly  Phe Leu Phe 
    1130                 1135                 1140             


Tyr Ala  Ser Gly Thr Phe Ser  Ser Pro Ser Tyr Pro  Ala Tyr Tyr 
    1145                 1150                 1155             


Pro Asn  Asn Ala Lys Cys Val  Trp Glu Ile Glu Val  Asn Ser Gly 
    1160                 1165                 1170             


Tyr Arg  Ile Asn Leu Gly Phe  Ser Asn Leu Lys Leu  Glu Ala His 
    1175                 1180                 1185             


His Asn  Cys Ser Phe Asp Tyr  Val Glu Ile Phe Asp  Gly Ser Leu 
    1190                 1195                 1200             


Asn Ser  Ser Leu Leu Leu Gly  Lys Ile Cys Asn Asp  Thr Arg Gln 
    1205                 1210                 1215             


Ile Phe  Thr Ser Ser Tyr Asn  Arg Met Thr Ile His  Phe Arg Ser 
    1220                 1225                 1230             


Asp Ile  Ser Phe Gln Asn Thr  Gly Phe Leu Ala Trp  Tyr Asn Ser 
    1235                 1240                 1245             


Phe Pro  Ser Asp Ala Thr Leu  Arg Leu Val Asn Leu  Asn Ser Ser 
    1250                 1255                 1260             


Tyr Gly  Leu Cys Ala Gly Arg  Val Glu Ile Tyr His  Gly Gly Thr 
    1265                 1270                 1275             


Trp Gly  Thr Val Cys Asp Asp  Ser Trp Thr Ile Gln  Glu Ala Glu 
    1280                 1285                 1290             


Val Val  Cys Arg Gln Leu Gly  Cys Gly Arg Ala Val  Ser Ala Leu 
    1295                 1300                 1305             


Gly Asn  Ala Tyr Phe Gly Ser  Gly Ser Gly Pro Ile  Thr Leu Asp 
    1310                 1315                 1320             


Asp Val  Glu Cys Ser Gly Thr  Glu Ser Thr Leu Trp  Gln Cys Arg 
    1325                 1330                 1335             


Asn Arg  Gly Trp Phe Ser His  Asn Cys Asn His Arg  Glu Asp Ala 
    1340                 1345                 1350             


Gly Val  Ile Cys Ser Gly Asn  His Leu Ser Thr Pro  Ala Pro Phe 
    1355                 1360                 1365             


Leu Asn  Ile Thr Arg Pro Asn  Thr Asp Tyr Ser Cys  Gly Gly Phe 
    1370                 1375                 1380             


Leu Ser  Gln Pro Ser Gly Asp  Phe Ser Ser Pro Phe  Tyr Pro Gly 
    1385                 1390                 1395             


Asn Tyr  Pro Asn Asn Ala Lys  Cys Val Trp Asp Ile  Glu Val Gln 
    1400                 1405                 1410             


Asn Asn  Tyr Arg Val Thr Val  Ile Phe Arg Asp Val  Gln Leu Glu 
    1415                 1420                 1425             


Gly Gly  Cys Asn Tyr Asp Tyr  Ile Glu Val Phe Asp  Gly Pro Tyr 
    1430                 1435                 1440             


Arg Ser  Ser Pro Leu Ile Ala  Arg Val Cys Asp Gly  Ala Arg Gly 
    1445                 1450                 1455             


Ser Phe  Thr Ser Ser Ser Asn  Phe Met Ser Ile Arg  Phe Ile Ser 
    1460                 1465                 1470             


Asp His  Ser Ile Thr Arg Arg  Gly Phe Arg Ala Glu  Tyr Tyr Ser 
    1475                 1480                 1485             


Ser Pro  Ser Asn Asp Ser Thr  Asn Leu Leu Cys Leu  Pro Asn His 
    1490                 1495                 1500             


Met Gln  Ala Ser Val Ser Arg  Ser Tyr Leu Gln Ser  Leu Gly Phe 
    1505                 1510                 1515             


Ser Ala  Ser Asp Leu Val Ile  Ser Thr Trp Asn Gly  Tyr Tyr Glu 
    1520                 1525                 1530             


Cys Arg  Pro Gln Ile Thr Pro  Asn Leu Val Ile Phe  Thr Ile Pro 
    1535                 1540                 1545             


Tyr Ser  Gly Cys Gly Thr Phe  Lys Gln Ala Asp Asn  Asp Thr Ile 
    1550                 1555                 1560             


Asp Tyr  Ser Asn Phe Leu Thr  Ala Ala Val Ser Gly  Gly Ile Ile 
    1565                 1570                 1575             


Lys Arg  Arg Thr Asp Leu Arg  Ile His Val Ser Cys  Arg Met Leu 
    1580                 1585                 1590             


Gln Asn  Thr Trp Val Asp Thr  Met Tyr Ile Ala Asn  Asp Thr Ile 
    1595                 1600                 1605             


His Val  Ala Asn Asn Thr Ile  Gln Val Glu Glu Val  Gln Tyr Gly 
    1610                 1615                 1620             


Asn Phe  Asp Val Asn Ile Ser  Phe Tyr Thr Ser Ser  Ser Phe Leu 
    1625                 1630                 1635             


Tyr Pro  Val Thr Ser Arg Pro  Tyr Tyr Val Asp Leu  Asn Gln Asp 
    1640                 1645                 1650             


Leu Tyr  Val Gln Ala Glu Ile  Leu His Ser Asp Ala  Val Leu Thr 
    1655                 1660                 1665             


Leu Phe  Val Asp Thr Cys Val  Ala Ser Pro Tyr Ser  Asn Asp Phe 
    1670                 1675                 1680             


Thr Ser  Leu Thr Tyr Asp Leu  Ile Arg Ser Gly Cys  Val Arg Asp 
    1685                 1690                 1695             


Asp Thr  Tyr Gly Pro Tyr Ser  Ser Pro Ser Leu Arg  Ile Ala Arg 
    1700                 1705                 1710             


Phe Arg  Phe Arg Ala Phe His  Phe Leu Asn Arg Phe  Pro Ser Val 
    1715                 1720                 1725             


Tyr Leu  Arg Cys Lys Met Val  Val Cys Arg Ala Tyr  Asp Pro Ser 
    1730                 1735                 1740             


Ser Arg  Cys Tyr Arg Gly Cys  Val Leu Arg Ser Lys  Arg Asp Val 
    1745                 1750                 1755             


Gly Ser  Tyr Gln Glu Lys Val  Asp Val Val Leu Gly  Pro Ile Gln 
    1760                 1765                 1770             


Leu Gln  Thr Pro Pro Arg Arg  Glu Glu Glu Pro Arg  
    1775                 1780                 1785 


<210>  4288
<211>  2403
<212>  PRT
<213>  Homo Sapiens

<400>  4288

Met Gly Ile Ser Thr Val Ile Leu Glu Met Cys Leu Leu Trp Gly Gln 
1               5                   10                  15      


Val Leu Ser Thr Gly Gly Trp Ile Pro Arg Thr Thr Asp Tyr Ala Ser 
            20                  25                  30          


Leu Ile Pro Ser Glu Val Pro Leu Asp Pro Thr Val Ala Glu Gly Ser 
        35                  40                  45              


Pro Phe Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
    50                  55                  60                  


Pro Ile Ser Leu Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
65                  70                  75                  80  


Leu Ile Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
                85                  90                  95      


Asp Ser Gly Leu Ala Leu Arg Leu Val Asn Gly Asp Gly Arg Cys Gln 
            100                 105                 110         


Gly Arg Val Glu Ile Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp 
        115                 120                 125             


Asp Ser Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly 
    130                 135                 140                 


Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Trp Phe Gly Gln Gly 
145                 150                 155                 160 


Ser Gly Pro Ile Ala Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser 
                165                 170                 175     


Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly 
            180                 185                 190         


His Gly Glu Asp Ala Gly Val Ile Cys Ser Ala Ala Gln Pro Gln Ser 
        195                 200                 205             


Thr Leu Arg Pro Glu Ser Trp Pro Val Arg Ile Ser Pro Pro Val Pro 
    210                 215                 220                 


Thr Glu Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly 
225                 230                 235                 240 


Asp Arg Cys Arg Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp Gly 
                245                 250                 255     


Thr Val Cys Asp Asp Tyr Trp Asp Thr Asn Asp Ala Asn Val Val Cys 
            260                 265                 270         


Arg Gln Leu Gly Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Gln 
        275                 280                 285             


Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser 
    290                 295                 300                 


Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Thr 
305                 310                 315                 320 


His Asn Cys Gly His Ser Glu Asp Ala Gly Val Ile Cys Ser Ala Pro 
                325                 330                 335     


Gln Ser Arg Pro Thr Pro Ser Pro Asp Thr Trp Pro Thr Ser His Ala 
            340                 345                 350         


Ser Thr Ala Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly 
        355                 360                 365             


Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp 
    370                 375                 380                 


Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Ser Asp Ala Asn Val Val 
385                 390                 395                 400 


Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly Asn Ala 
                405                 410                 415     


Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys 
            420                 425                 430         


Ser Gly Tyr Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu 
        435                 440                 445             


Ser His Asn Cys Gln His Ser Glu Asp Ala Gly Val Ile Cys Ser Asp 
    450                 455                 460                 


Thr Leu Pro Thr Ile Thr Leu Pro Ala Ser Thr Val Gly Ser Glu Ser 
465                 470                 475                 480 


Ser Leu Ala Leu Arg Leu Val Asn Gly Gly Asp Arg Cys Gln Gly Arg 
                485                 490                 495     


Val Glu Val Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp Asp Ser 
            500                 505                 510         


Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly 
        515                 520                 525             


Trp Ala Met Leu Ala Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly 
    530                 535                 540                 


Pro Ile Val Leu Asp Asp Val Arg Cys Ser Gly Asn Glu Ser Tyr Leu 
545                 550                 555                 560 


Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly His Ser 
                565                 570                 575     


Glu Asp Ala Gly Val Ile Cys Ser Gly Pro Glu Ser Ser Leu Ala Leu 
            580                 585                 590         


Arg Leu Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu 
        595                 600                 605             


Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Asn 
    610                 615                 620                 


Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser 
625                 630                 635                 640 


Ala Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu 
                645                 650                 655     


Asp Asp Val Arg Cys Ser Gly His Glu Ser Tyr Leu Trp Ser Cys Pro 
            660                 665                 670         


Asn Asn Gly Trp Leu Ser His Asn Cys Gly His His Glu Asp Ala Gly 
        675                 680                 685             


Val Ile Cys Ser Ala Ala Gln Ser Arg Ser Thr Pro Arg Pro Asp Thr 
    690                 695                 700                 


Leu Ser Thr Ile Thr Leu Pro Pro Ser Thr Val Gly Ser Glu Ser Ser 
705                 710                 715                 720 


Leu Thr Leu Arg Leu Val Asn Gly Ser Asp Arg Cys Gln Gly Arg Val 
                725                 730                 735     


Glu Val Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp 
            740                 745                 750         


Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp 
        755                 760                 765             


Ala Thr Ser Ala Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro 
    770                 775                 780                 


Ile Val Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser Tyr Leu Trp 
785                 790                 795                 800 


Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly His His Glu 
                805                 810                 815     


Asp Ala Gly Val Ile Cys Ser Val Ser Gln Ser Arg Pro Thr Pro Ser 
            820                 825                 830         


Pro Asp Thr Trp Pro Thr Ser His Ala Ser Thr Ala Gly Pro Glu Ser 
        835                 840                 845             


Ser Leu Ala Leu Arg Leu Val Asn Gly Gly Asp Arg Cys Gln Gly Arg 
    850                 855                 860                 


Val Glu Val Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp Asp Ser 
865                 870                 875                 880 


Trp Asp Thr Ser Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly 
                885                 890                 895     


Trp Ala Thr Ser Ala Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly 
            900                 905                 910         


Pro Ile Val Leu Asp Asp Val Arg Cys Ser Gly Tyr Glu Ser Tyr Leu 
        915                 920                 925             


Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gln His Ser 
    930                 935                 940                 


Glu Asp Ala Gly Val Ile Cys Ser Ala Ala His Ser Trp Ser Thr Pro 
945                 950                 955                 960 


Ser Pro Asp Thr Leu Pro Thr Ile Thr Leu Pro Ala Ser Thr Val Gly 
                965                 970                 975     


Ser Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly Asp Arg Cys 
            980                 985                 990         


Gln Gly Arg Val Glu Val Leu Tyr  Gln Gly Ser Trp Gly  Thr Val Cys 
        995                 1000                 1005             


Asp Asp  Ser Trp Asp Thr Asn  Asp Ala Asn Val Val  Cys Arg Gln 
    1010                 1015                 1020             


Leu Gly  Cys Gly Trp Ala Met  Ser Ala Pro Gly Asn  Ala Arg Phe 
    1025                 1030                 1035             


Gly Gln  Gly Ser Gly Pro Ile  Val Leu Asp Asp Val  Arg Cys Ser 
    1040                 1045                 1050             


Gly His  Glu Ser Tyr Leu Trp  Ser Cys Pro His Asn  Gly Trp Leu 
    1055                 1060                 1065             


Ser His  Asn Cys Gly His Ser  Glu Asp Ala Gly Val  Ile Cys Ser 
    1070                 1075                 1080             


Ala Ser  Gln Ser Arg Pro Thr  Pro Ser Pro Asp Thr  Trp Pro Thr 
    1085                 1090                 1095             


Ser His  Ala Ser Thr Ala Gly  Ser Glu Ser Ser Leu  Ala Leu Arg 
    1100                 1105                 1110             


Leu Val  Asn Gly Gly Asp Arg  Cys Gln Gly Arg Val  Glu Val Leu 
    1115                 1120                 1125             


Tyr Arg  Gly Ser Trp Gly Thr  Val Cys Asp Asp Tyr  Trp Asp Thr 
    1130                 1135                 1140             


Asn Asp  Ala Asn Val Val Cys  Arg Gln Leu Gly Cys  Gly Trp Ala 
    1145                 1150                 1155             


Met Ser  Ala Pro Gly Asn Ala  Arg Phe Gly Gln Gly  Ser Gly Pro 
    1160                 1165                 1170             


Ile Val  Leu Asp Asp Val Arg  Cys Ser Gly His Glu  Ser Tyr Leu 
    1175                 1180                 1185             


Trp Ser  Cys Pro His Asn Gly  Trp Leu Ser His Asn  Cys Gly His 
    1190                 1195                 1200             


His Glu  Asp Ala Gly Val Ile  Cys Ser Ala Ser Gln  Ser Gln Pro 
    1205                 1210                 1215             


Thr Pro  Ser Pro Asp Thr Trp  Pro Thr Ser His Ala  Ser Thr Ala 
    1220                 1225                 1230             


Gly Ser  Glu Ser Ser Leu Ala  Leu Arg Leu Val Asn  Gly Gly Asp 
    1235                 1240                 1245             


Arg Cys  Gln Gly Arg Val Glu  Val Leu Tyr Arg Gly  Ser Trp Gly 
    1250                 1255                 1260             


Thr Val  Cys Asp Asp Tyr Trp  Asp Thr Asn Asp Ala  Asn Val Val 
    1265                 1270                 1275             


Cys Arg  Gln Leu Gly Cys Gly  Trp Ala Thr Ser Ala  Pro Gly Asn 
    1280                 1285                 1290             


Ala Arg  Phe Gly Gln Gly Ser  Gly Pro Ile Val Leu  Asp Asp Val 
    1295                 1300                 1305             


Arg Cys  Ser Gly His Glu Ser  Tyr Leu Trp Ser Cys  Pro His Asn 
    1310                 1315                 1320             


Gly Trp  Leu Ser His Asn Cys  Gly His His Glu Asp  Ala Gly Val 
    1325                 1330                 1335             


Ile Cys  Ser Ala Ser Gln Ser  Gln Pro Thr Pro Ser  Pro Asp Thr 
    1340                 1345                 1350             


Trp Pro  Thr Ser His Ala Ser  Thr Ala Gly Ser Glu  Ser Ser Leu 
    1355                 1360                 1365             


Ala Leu  Arg Leu Val Asn Gly  Gly Asp Arg Cys Gln  Gly Arg Val 
    1370                 1375                 1380             


Glu Val  Leu Tyr Arg Gly Ser  Trp Gly Thr Val Cys  Asp Asp Tyr 
    1385                 1390                 1395             


Trp Asp  Thr Asn Asp Ala Asn  Val Val Cys Arg Gln  Leu Gly Cys 
    1400                 1405                 1410             


Gly Trp  Ala Thr Ser Ala Pro  Gly Asn Ala Arg Phe  Gly Gln Gly 
    1415                 1420                 1425             


Ser Gly  Pro Ile Val Leu Asp  Asp Val Arg Cys Ser  Gly His Glu 
    1430                 1435                 1440             


Ser Tyr  Leu Trp Ser Cys Pro  His Asn Gly Trp Leu  Ser His Asn 
    1445                 1450                 1455             


Cys Gly  His His Glu Asp Ala  Gly Val Ile Cys Ser  Ala Ser Gln 
    1460                 1465                 1470             


Ser Gln  Pro Thr Pro Ser Pro  Asp Thr Trp Pro Thr  Ser Arg Ala 
    1475                 1480                 1485             


Ser Thr  Ala Gly Ser Glu Ser  Thr Leu Ala Leu Arg  Leu Val Asn 
    1490                 1495                 1500             


Gly Gly  Asp Arg Cys Arg Gly  Arg Val Glu Val Leu  Tyr Gln Gly 
    1505                 1510                 1515             


Ser Trp  Gly Thr Val Cys Asp  Asp Tyr Trp Asp Thr  Asn Asp Ala 
    1520                 1525                 1530             


Asn Val  Val Cys Arg Gln Leu  Gly Cys Gly Trp Ala  Met Ser Ala 
    1535                 1540                 1545             


Pro Gly  Asn Ala Gln Phe Gly  Gln Gly Ser Gly Pro  Ile Val Leu 
    1550                 1555                 1560             


Asp Asp  Val Arg Cys Ser Gly  His Glu Ser Tyr Leu  Trp Ser Cys 
    1565                 1570                 1575             


Pro His  Asn Gly Trp Leu Ser  His Asn Cys Gly His  His Glu Asp 
    1580                 1585                 1590             


Ala Gly  Val Ile Cys Ser Ala  Ala Gln Ser Gln Ser  Thr Pro Arg 
    1595                 1600                 1605             


Pro Asp  Thr Trp Leu Thr Thr  Asn Leu Pro Ala Leu  Thr Val Gly 
    1610                 1615                 1620             


Ser Glu  Ser Ser Leu Ala Leu  Arg Leu Val Asn Gly  Gly Asp Arg 
    1625                 1630                 1635             


Cys Arg  Gly Arg Val Glu Val  Leu Tyr Arg Gly Ser  Trp Gly Thr 
    1640                 1645                 1650             


Val Cys  Asp Asp Ser Trp Asp  Thr Asn Asp Ala Asn  Val Val Cys 
    1655                 1660                 1665             


Arg Gln  Leu Gly Cys Gly Trp  Ala Met Ser Ala Pro  Gly Asn Ala 
    1670                 1675                 1680             


Arg Phe  Gly Gln Gly Ser Gly  Pro Ile Val Leu Asp  Asp Val Arg 
    1685                 1690                 1695             


Cys Ser  Gly Asn Glu Ser Tyr  Leu Trp Ser Cys Pro  His Lys Gly 
    1700                 1705                 1710             


Trp Leu  Thr His Asn Cys Gly  His His Glu Asp Ala  Gly Val Ile 
    1715                 1720                 1725             


Cys Ser  Ala Thr Gln Ile Asn  Ser Thr Thr Thr Asp  Trp Trp His 
    1730                 1735                 1740             


Pro Thr  Thr Thr Thr Thr Ala  Arg Pro Ser Ser Asn  Cys Gly Gly 
    1745                 1750                 1755             


Phe Leu  Phe Tyr Ala Ser Gly  Thr Phe Ser Ser Pro  Ser Tyr Pro 
    1760                 1765                 1770             


Ala Tyr  Tyr Pro Asn Asn Ala  Lys Cys Val Trp Glu  Ile Glu Val 
    1775                 1780                 1785             


Asn Ser  Gly Tyr Arg Ile Asn  Leu Gly Phe Ser Asn  Leu Lys Leu 
    1790                 1795                 1800             


Glu Ala  His His Asn Cys Ser  Phe Asp Tyr Val Glu  Ile Phe Asp 
    1805                 1810                 1815             


Gly Ser  Leu Asn Ser Ser Leu  Leu Leu Gly Lys Ile  Cys Asn Asp 
    1820                 1825                 1830             


Thr Arg  Gln Ile Phe Thr Ser  Ser Tyr Asn Arg Met  Thr Ile His 
    1835                 1840                 1845             


Phe Arg  Ser Asp Ile Ser Phe  Gln Asn Thr Gly Phe  Leu Ala Trp 
    1850                 1855                 1860             


Tyr Asn  Ser Phe Pro Ser Asp  Ala Thr Leu Arg Leu  Val Asn Leu 
    1865                 1870                 1875             


Asn Ser  Ser Tyr Gly Leu Cys  Ala Gly Arg Val Glu  Ile Tyr His 
    1880                 1885                 1890             


Gly Gly  Thr Trp Gly Thr Val  Cys Asp Asp Ser Trp  Thr Ile Gln 
    1895                 1900                 1905             


Glu Ala  Glu Val Val Cys Arg  Gln Leu Gly Cys Gly  Arg Ala Val 
    1910                 1915                 1920             


Ser Ala  Leu Gly Asn Ala Tyr  Phe Gly Ser Gly Ser  Gly Pro Ile 
    1925                 1930                 1935             


Thr Leu  Asp Asp Val Glu Cys  Ser Gly Thr Glu Ser  Thr Leu Trp 
    1940                 1945                 1950             


Gln Cys  Arg Asn Arg Gly Trp  Phe Ser His Asn Cys  Asn His Arg 
    1955                 1960                 1965             


Glu Asp  Ala Gly Val Ile Cys  Ser Gly Asn His Leu  Ser Thr Pro 
    1970                 1975                 1980             


Ala Pro  Phe Leu Asn Ile Thr  Arg Pro Asn Thr Asp  Tyr Ser Cys 
    1985                 1990                 1995             


Gly Gly  Phe Leu Ser Gln Pro  Ser Gly Asp Phe Ser  Ser Pro Phe 
    2000                 2005                 2010             


Tyr Pro  Gly Asn Tyr Pro Asn  Asn Ala Lys Cys Val  Trp Asp Ile 
    2015                 2020                 2025             


Glu Val  Gln Asn Asn Tyr Arg  Val Thr Val Ile Phe  Arg Asp Val 
    2030                 2035                 2040             


Gln Leu  Glu Gly Gly Cys Asn  Tyr Asp Tyr Ile Glu  Val Phe Asp 
    2045                 2050                 2055             


Gly Pro  Tyr Arg Ser Ser Pro  Leu Ile Ala Arg Val  Cys Asp Gly 
    2060                 2065                 2070             


Ala Arg  Gly Ser Phe Thr Ser  Ser Ser Asn Phe Met  Ser Ile Arg 
    2075                 2080                 2085             


Phe Ile  Ser Asp His Ser Ile  Thr Arg Arg Gly Phe  Arg Ala Glu 
    2090                 2095                 2100             


Tyr Tyr  Ser Ser Pro Ser Asn  Asp Ser Thr Asn Leu  Leu Cys Leu 
    2105                 2110                 2115             


Pro Asn  His Met Gln Ala Ser  Val Ser Arg Ser Tyr  Leu Gln Ser 
    2120                 2125                 2130             


Leu Gly  Phe Ser Ala Ser Asp  Leu Val Ile Ser Thr  Trp Asn Gly 
    2135                 2140                 2145             


Tyr Tyr  Glu Cys Arg Pro Gln  Ile Thr Pro Asn Leu  Val Ile Phe 
    2150                 2155                 2160             


Thr Ile  Pro Tyr Ser Gly Cys  Gly Thr Phe Lys Gln  Ala Asp Asn 
    2165                 2170                 2175             


Asp Thr  Ile Asp Tyr Ser Asn  Phe Leu Thr Ala Ala  Val Ser Gly 
    2180                 2185                 2190             


Gly Ile  Ile Lys Arg Arg Thr  Asp Leu Arg Ile His  Val Ser Cys 
    2195                 2200                 2205             


Arg Met  Leu Gln Asn Thr Trp  Val Asp Thr Met Tyr  Ile Ala Asn 
    2210                 2215                 2220             


Asp Thr  Ile His Val Ala Asn  Asn Thr Ile Gln Val  Glu Glu Val 
    2225                 2230                 2235             


Gln Tyr  Gly Asn Phe Asp Val  Asn Ile Ser Phe Tyr  Thr Ser Ser 
    2240                 2245                 2250             


Ser Phe  Leu Tyr Pro Val Thr  Ser Arg Pro Tyr Tyr  Val Asp Leu 
    2255                 2260                 2265             


Asn Gln  Asp Leu Tyr Val Gln  Ala Glu Ile Leu His  Ser Asp Ala 
    2270                 2275                 2280             


Val Leu  Thr Leu Phe Val Asp  Thr Cys Val Ala Ser  Pro Tyr Ser 
    2285                 2290                 2295             


Asn Asp  Phe Thr Ser Leu Thr  Tyr Asp Leu Ile Arg  Ser Gly Cys 
    2300                 2305                 2310             


Val Arg  Asp Asp Thr Tyr Gly  Pro Tyr Ser Ser Pro  Ser Leu Arg 
    2315                 2320                 2325             


Ile Ala  Arg Phe Arg Phe Arg  Ala Phe His Phe Leu  Asn Arg Phe 
    2330                 2335                 2340             


Pro Ser  Val Tyr Leu Arg Cys  Lys Met Val Val Cys  Arg Ala Tyr 
    2345                 2350                 2355             


Asp Pro  Ser Ser Arg Cys Tyr  Arg Gly Cys Val Leu  Arg Ser Lys 
    2360                 2365                 2370             


Arg Asp  Val Gly Ser Tyr Gln  Glu Lys Val Asp Val  Val Leu Gly 
    2375                 2380                 2385             


Pro Ile  Gln Leu Gln Thr Pro  Pro Arg Arg Glu Glu  Glu Pro Arg 
    2390                 2395                 2400             


<210>  4289
<211>  2413
<212>  PRT
<213>  Homo Sapiens

<400>  4289

Met Gly Ile Ser Thr Val Ile Leu Glu Met Cys Leu Leu Trp Gly Gln 
1               5                   10                  15      


Val Leu Ser Thr Gly Gly Trp Ile Pro Arg Thr Thr Asp Tyr Ala Ser 
            20                  25                  30          


Leu Ile Pro Ser Glu Val Pro Leu Asp Pro Thr Val Ala Glu Gly Ser 
        35                  40                  45              


Pro Phe Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
    50                  55                  60                  


Pro Ile Ser Leu Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
65                  70                  75                  80  


Leu Ile Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
                85                  90                  95      


Asp Ser Gly Leu Ala Leu Arg Leu Val Asn Gly Asp Gly Arg Cys Gln 
            100                 105                 110         


Gly Arg Val Glu Ile Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp 
        115                 120                 125             


Asp Ser Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly 
    130                 135                 140                 


Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Trp Phe Gly Gln Gly 
145                 150                 155                 160 


Ser Gly Pro Ile Ala Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser 
                165                 170                 175     


Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly 
            180                 185                 190         


His Gly Glu Asp Ala Gly Val Ile Cys Ser Ala Ala Gln Pro Gln Ser 
        195                 200                 205             


Thr Leu Arg Pro Glu Ser Trp Pro Val Arg Ile Ser Pro Pro Val Pro 
    210                 215                 220                 


Thr Glu Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly 
225                 230                 235                 240 


Asp Arg Cys Arg Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp Gly 
                245                 250                 255     


Thr Val Cys Asp Asp Tyr Trp Asp Thr Asn Asp Ala Asn Val Val Cys 
            260                 265                 270         


Arg Gln Leu Gly Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Gln 
        275                 280                 285             


Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser 
    290                 295                 300                 


Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Thr 
305                 310                 315                 320 


His Asn Cys Gly His Ser Glu Asp Ala Gly Val Ile Cys Ser Ala Pro 
                325                 330                 335     


Gln Ser Arg Pro Thr Pro Ser Pro Asp Thr Trp Pro Thr Ser His Ala 
            340                 345                 350         


Ser Thr Ala Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly 
        355                 360                 365             


Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp 
    370                 375                 380                 


Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Ser Asp Ala Asn Val Val 
385                 390                 395                 400 


Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly Asn Ala 
                405                 410                 415     


Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys 
            420                 425                 430         


Ser Gly Tyr Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu 
        435                 440                 445             


Ser His Asn Cys Gln His Ser Glu Asp Ala Gly Val Ile Cys Ser Ala 
    450                 455                 460                 


Ala His Ser Trp Ser Thr Pro Ser Pro Asp Thr Leu Pro Thr Ile Thr 
465                 470                 475                 480 


Leu Pro Ala Ser Thr Val Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu 
                485                 490                 495     


Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg 
            500                 505                 510         


Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Asn Asp Ala 
        515                 520                 525             


Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Met Leu Ala Pro 
    530                 535                 540                 


Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp 
545                 550                 555                 560 


Val Arg Cys Ser Gly Asn Glu Ser Tyr Leu Trp Ser Cys Pro His Asn 
                565                 570                 575     


Gly Trp Leu Ser His Asn Cys Gly His Ser Glu Asp Ala Gly Val Ile 
            580                 585                 590         


Cys Ser Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly 
        595                 600                 605             


Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp Gly 
    610                 615                 620                 


Thr Val Cys Asp Asp Ser Trp Asp Thr Asn Asp Ala Asn Val Val Cys 
625                 630                 635                 640 


Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly Asn Ala Arg 
                645                 650                 655     


Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser 
            660                 665                 670         


Gly His Glu Ser Tyr Leu Trp Ser Cys Pro Asn Asn Gly Trp Leu Ser 
        675                 680                 685             


His Asn Cys Gly His His Glu Asp Ala Gly Val Ile Cys Ser Ala Ala 
    690                 695                 700                 


Gln Ser Arg Ser Thr Pro Arg Pro Asp Thr Leu Ser Thr Ile Thr Leu 
705                 710                 715                 720 


Pro Pro Ser Thr Val Gly Ser Glu Ser Ser Leu Thr Leu Arg Leu Val 
                725                 730                 735     


Asn Gly Ser Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly 
            740                 745                 750         


Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Asn Asp Ala Asn 
        755                 760                 765             


Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly 
    770                 775                 780                 


Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val 
785                 790                 795                 800 


Arg Cys Ser Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly 
                805                 810                 815     


Trp Leu Ser His Asn Cys Gly His His Glu Asp Ala Gly Val Ile Cys 
            820                 825                 830         


Ser Val Ser Gln Ser Arg Pro Thr Pro Ser Pro Asp Thr Trp Pro Thr 
        835                 840                 845             


Ser His Ala Ser Thr Ala Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu 
    850                 855                 860                 


Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg 
865                 870                 875                 880 


Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Ser Asp Ala 
                885                 890                 895     


Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro 
            900                 905                 910         


Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp 
        915                 920                 925             


Val Arg Cys Ser Gly Tyr Glu Ser Tyr Leu Trp Ser Cys Pro His Asn 
    930                 935                 940                 


Gly Trp Leu Ser His Asn Cys Gln His Ser Glu Asp Ala Gly Val Ile 
945                 950                 955                 960 


Cys Ser Ala Ala His Ser Trp Ser Thr Pro Ser Pro Asp Thr Leu Pro 
                965                 970                 975     


Thr Ile Thr Leu Pro Ala Ser Thr Val Gly Ser Glu Ser Ser Leu Ala 
            980                 985                 990         


Leu Arg Leu Val Asn Gly Gly Asp  Arg Cys Gln Gly Arg  Val Glu Val 
        995                 1000                 1005             


Leu Tyr  Gln Gly Ser Trp Gly  Thr Val Cys Asp Asp  Ser Trp Asp 
    1010                 1015                 1020             


Thr Asn  Asp Ala Asn Val Val  Cys Arg Gln Leu Gly  Cys Gly Trp 
    1025                 1030                 1035             


Ala Met  Ser Ala Pro Gly Asn  Ala Arg Phe Gly Gln  Gly Ser Gly 
    1040                 1045                 1050             


Pro Ile  Val Leu Asp Asp Val  Arg Cys Ser Gly His  Glu Ser Tyr 
    1055                 1060                 1065             


Leu Trp  Ser Cys Pro His Asn  Gly Trp Leu Ser His  Asn Cys Gly 
    1070                 1075                 1080             


His Ser  Glu Asp Ala Gly Val  Ile Cys Ser Ala Ser  Gln Ser Arg 
    1085                 1090                 1095             


Pro Thr  Pro Ser Pro Asp Thr  Trp Pro Thr Ser His  Ala Ser Thr 
    1100                 1105                 1110             


Ala Gly  Ser Glu Ser Ser Leu  Ala Leu Arg Leu Val  Asn Gly Gly 
    1115                 1120                 1125             


Asp Arg  Cys Gln Gly Arg Val  Glu Val Leu Tyr Arg  Gly Ser Trp 
    1130                 1135                 1140             


Gly Thr  Val Cys Asp Asp Tyr  Trp Asp Thr Asn Asp  Ala Asn Val 
    1145                 1150                 1155             


Val Cys  Arg Gln Leu Gly Cys  Gly Trp Ala Met Ser  Ala Pro Gly 
    1160                 1165                 1170             


Asn Ala  Arg Phe Gly Gln Gly  Ser Gly Pro Ile Val  Leu Asp Asp 
    1175                 1180                 1185             


Val Arg  Cys Ser Gly His Glu  Ser Tyr Leu Trp Ser  Cys Pro His 
    1190                 1195                 1200             


Asn Gly  Trp Leu Ser His Asn  Cys Gly His His Glu  Asp Ala Gly 
    1205                 1210                 1215             


Val Ile  Cys Ser Ala Ser Gln  Ser Gln Pro Thr Pro  Ser Pro Asp 
    1220                 1225                 1230             


Thr Trp  Pro Thr Ser His Ala  Ser Thr Ala Gly Ser  Glu Ser Ser 
    1235                 1240                 1245             


Leu Ala  Leu Arg Leu Val Asn  Gly Gly Asp Arg Cys  Gln Gly Arg 
    1250                 1255                 1260             


Val Glu  Val Leu Tyr Arg Gly  Ser Trp Gly Thr Val  Cys Asp Asp 
    1265                 1270                 1275             


Tyr Trp  Asp Thr Asn Asp Ala  Asn Val Val Cys Arg  Gln Leu Gly 
    1280                 1285                 1290             


Cys Gly  Trp Ala Thr Ser Ala  Pro Gly Asn Ala Arg  Phe Gly Gln 
    1295                 1300                 1305             


Gly Ser  Gly Pro Ile Val Leu  Asp Asp Val Arg Cys  Ser Gly His 
    1310                 1315                 1320             


Glu Ser  Tyr Leu Trp Ser Cys  Pro His Asn Gly Trp  Leu Ser His 
    1325                 1330                 1335             


Asn Cys  Gly His His Glu Asp  Ala Gly Val Ile Cys  Ser Ala Ser 
    1340                 1345                 1350             


Gln Ser  Gln Pro Thr Pro Ser  Pro Asp Thr Trp Pro  Thr Ser His 
    1355                 1360                 1365             


Ala Ser  Thr Ala Gly Ser Glu  Ser Ser Leu Ala Leu  Arg Leu Val 
    1370                 1375                 1380             


Asn Gly  Gly Asp Arg Cys Gln  Gly Arg Val Glu Val  Leu Tyr Arg 
    1385                 1390                 1395             


Gly Ser  Trp Gly Thr Val Cys  Asp Asp Tyr Trp Asp  Thr Asn Asp 
    1400                 1405                 1410             


Ala Asn  Val Val Cys Arg Gln  Leu Gly Cys Gly Trp  Ala Thr Ser 
    1415                 1420                 1425             


Ala Pro  Gly Asn Ala Arg Phe  Gly Gln Gly Ser Gly  Pro Ile Val 
    1430                 1435                 1440             


Leu Asp  Asp Val Arg Cys Ser  Gly His Glu Ser Tyr  Leu Trp Ser 
    1445                 1450                 1455             


Cys Pro  His Asn Gly Trp Leu  Ser His Asn Cys Gly  His His Glu 
    1460                 1465                 1470             


Asp Ala  Gly Val Ile Cys Ser  Ala Ser Gln Ser Gln  Pro Thr Pro 
    1475                 1480                 1485             


Ser Pro  Asp Thr Trp Pro Thr  Ser Arg Ala Ser Thr  Ala Gly Ser 
    1490                 1495                 1500             


Glu Ser  Thr Leu Ala Leu Arg  Leu Val Asn Gly Gly  Asp Arg Cys 
    1505                 1510                 1515             


Arg Gly  Arg Val Glu Val Leu  Tyr Gln Gly Ser Trp  Gly Thr Val 
    1520                 1525                 1530             


Cys Asp  Asp Tyr Trp Asp Thr  Asn Asp Ala Asn Val  Val Cys Arg 
    1535                 1540                 1545             


Gln Leu  Gly Cys Gly Trp Ala  Met Ser Ala Pro Gly  Asn Ala Gln 
    1550                 1555                 1560             


Phe Gly  Gln Gly Ser Gly Pro  Ile Val Leu Asp Asp  Val Arg Cys 
    1565                 1570                 1575             


Ser Gly  His Glu Ser Tyr Leu  Trp Ser Cys Pro His  Asn Gly Trp 
    1580                 1585                 1590             


Leu Ser  His Asn Cys Gly His  His Glu Asp Ala Gly  Val Ile Cys 
    1595                 1600                 1605             


Ser Ala  Ala Gln Ser Gln Ser  Thr Pro Arg Pro Asp  Thr Trp Leu 
    1610                 1615                 1620             


Thr Thr  Asn Leu Pro Ala Leu  Thr Val Gly Ser Glu  Ser Ser Leu 
    1625                 1630                 1635             


Ala Leu  Arg Leu Val Asn Gly  Gly Asp Arg Cys Arg  Gly Arg Val 
    1640                 1645                 1650             


Glu Val  Leu Tyr Arg Gly Ser  Trp Gly Thr Val Cys  Asp Asp Ser 
    1655                 1660                 1665             


Trp Asp  Thr Asn Asp Ala Asn  Val Val Cys Arg Gln  Leu Gly Cys 
    1670                 1675                 1680             


Gly Trp  Ala Met Ser Ala Pro  Gly Asn Ala Arg Phe  Gly Gln Gly 
    1685                 1690                 1695             


Ser Gly  Pro Ile Val Leu Asp  Asp Val Arg Cys Ser  Gly Asn Glu 
    1700                 1705                 1710             


Ser Tyr  Leu Trp Ser Cys Pro  His Lys Gly Trp Leu  Thr His Asn 
    1715                 1720                 1725             


Cys Gly  His His Glu Asp Ala  Gly Val Ile Cys Ser  Ala Thr Gln 
    1730                 1735                 1740             


Ile Asn  Ser Thr Thr Thr Asp  Trp Trp His Pro Thr  Thr Thr Thr 
    1745                 1750                 1755             


Thr Ala  Arg Pro Ser Ser Asn  Cys Gly Gly Phe Leu  Phe Tyr Ala 
    1760                 1765                 1770             


Ser Gly  Thr Phe Ser Ser Pro  Ser Tyr Pro Ala Tyr  Tyr Pro Asn 
    1775                 1780                 1785             


Asn Ala  Lys Cys Val Trp Glu  Ile Glu Val Asn Ser  Gly Tyr Arg 
    1790                 1795                 1800             


Ile Asn  Leu Gly Phe Ser Asn  Leu Lys Leu Glu Ala  His His Asn 
    1805                 1810                 1815             


Cys Ser  Phe Asp Tyr Val Glu  Ile Phe Asp Gly Ser  Leu Asn Ser 
    1820                 1825                 1830             


Ser Leu  Leu Leu Gly Lys Ile  Cys Asn Asp Thr Arg  Gln Ile Phe 
    1835                 1840                 1845             


Thr Ser  Ser Tyr Asn Arg Met  Thr Ile His Phe Arg  Ser Asp Ile 
    1850                 1855                 1860             


Ser Phe  Gln Asn Thr Gly Phe  Leu Ala Trp Tyr Asn  Ser Phe Pro 
    1865                 1870                 1875             


Ser Asp  Ala Thr Leu Arg Leu  Val Asn Leu Asn Ser  Ser Tyr Gly 
    1880                 1885                 1890             


Leu Cys  Ala Gly Arg Val Glu  Ile Tyr His Gly Gly  Thr Trp Gly 
    1895                 1900                 1905             


Thr Val  Cys Asp Asp Ser Trp  Thr Ile Gln Glu Ala  Glu Val Val 
    1910                 1915                 1920             


Cys Arg  Gln Leu Gly Cys Gly  Arg Ala Val Ser Ala  Leu Gly Asn 
    1925                 1930                 1935             


Ala Tyr  Phe Gly Ser Gly Ser  Gly Pro Ile Thr Leu  Asp Asp Val 
    1940                 1945                 1950             


Glu Cys  Ser Gly Thr Glu Ser  Thr Leu Trp Gln Cys  Arg Asn Arg 
    1955                 1960                 1965             


Gly Trp  Phe Ser His Asn Cys  Asn His Arg Glu Asp  Ala Gly Val 
    1970                 1975                 1980             


Ile Cys  Ser Gly Asn His Leu  Ser Thr Pro Ala Pro  Phe Leu Asn 
    1985                 1990                 1995             


Ile Thr  Arg Pro Asn Thr Asp  Tyr Ser Cys Gly Gly  Phe Leu Ser 
    2000                 2005                 2010             


Gln Pro  Ser Gly Asp Phe Ser  Ser Pro Phe Tyr Pro  Gly Asn Tyr 
    2015                 2020                 2025             


Pro Asn  Asn Ala Lys Cys Val  Trp Asp Ile Glu Val  Gln Asn Asn 
    2030                 2035                 2040             


Tyr Arg  Val Thr Val Ile Phe  Arg Asp Val Gln Leu  Glu Gly Gly 
    2045                 2050                 2055             


Cys Asn  Tyr Asp Tyr Ile Glu  Val Phe Asp Gly Pro  Tyr Arg Ser 
    2060                 2065                 2070             


Ser Pro  Leu Ile Ala Arg Val  Cys Asp Gly Ala Arg  Gly Ser Phe 
    2075                 2080                 2085             


Thr Ser  Ser Ser Asn Phe Met  Ser Ile Arg Phe Ile  Ser Asp His 
    2090                 2095                 2100             


Ser Ile  Thr Arg Arg Gly Phe  Arg Ala Glu Tyr Tyr  Ser Ser Pro 
    2105                 2110                 2115             


Ser Asn  Asp Ser Thr Asn Leu  Leu Cys Leu Pro Asn  His Met Gln 
    2120                 2125                 2130             


Ala Ser  Val Ser Arg Ser Tyr  Leu Gln Ser Leu Gly  Phe Ser Ala 
    2135                 2140                 2145             


Ser Asp  Leu Val Ile Ser Thr  Trp Asn Gly Tyr Tyr  Glu Cys Arg 
    2150                 2155                 2160             


Pro Gln  Ile Thr Pro Asn Leu  Val Ile Phe Thr Ile  Pro Tyr Ser 
    2165                 2170                 2175             


Gly Cys  Gly Thr Phe Lys Gln  Ala Asp Asn Asp Thr  Ile Asp Tyr 
    2180                 2185                 2190             


Ser Asn  Phe Leu Thr Ala Ala  Val Ser Gly Gly Ile  Ile Lys Arg 
    2195                 2200                 2205             


Arg Thr  Asp Leu Arg Ile His  Val Ser Cys Arg Met  Leu Gln Asn 
    2210                 2215                 2220             


Thr Trp  Val Asp Thr Met Tyr  Ile Ala Asn Asp Thr  Ile His Val 
    2225                 2230                 2235             


Ala Asn  Asn Thr Ile Gln Val  Glu Glu Val Gln Tyr  Gly Asn Phe 
    2240                 2245                 2250             


Asp Val  Asn Ile Ser Phe Tyr  Thr Ser Ser Ser Phe  Leu Tyr Pro 
    2255                 2260                 2265             


Val Thr  Ser Arg Pro Tyr Tyr  Val Asp Leu Asn Gln  Asp Leu Tyr 
    2270                 2275                 2280             


Val Gln  Ala Glu Ile Leu His  Ser Asp Ala Val Leu  Thr Leu Phe 
    2285                 2290                 2295             


Val Asp  Thr Cys Val Ala Ser  Pro Tyr Ser Asn Asp  Phe Thr Ser 
    2300                 2305                 2310             


Leu Thr  Tyr Asp Leu Ile Arg  Ser Gly Cys Val Arg  Asp Asp Thr 
    2315                 2320                 2325             


Tyr Gly  Pro Tyr Ser Ser Pro  Ser Leu Arg Ile Ala  Arg Phe Arg 
    2330                 2335                 2340             


Phe Arg  Ala Phe His Phe Leu  Asn Arg Phe Pro Ser  Val Tyr Leu 
    2345                 2350                 2355             


Arg Cys  Lys Met Val Val Cys  Arg Ala Tyr Asp Pro  Ser Ser Arg 
    2360                 2365                 2370             


Cys Tyr  Arg Gly Cys Val Leu  Arg Ser Lys Arg Asp  Val Gly Ser 
    2375                 2380                 2385             


Tyr Gln  Glu Lys Val Asp Val  Val Leu Gly Pro Ile  Gln Leu Gln 
    2390                 2395                 2400             


Thr Pro  Pro Arg Arg Glu Glu  Glu Pro Arg 
    2405                 2410             


<210>  4290
<211>  33
<212>  PRT
<213>  Homo Sapiens

<400>  4290

Met Phe Asn Phe Asp Thr Phe Trp Lys Asn Phe Lys Ser Lys Leu Gly 
1               5                   10                  15      


Phe Ile Asn Trp Asp Ala Ile Asn Lys Asp Gln Arg Ser Ser Arg Ile 
            20                  25                  30          


Pro 
    


<210>  4291
<211>  33
<212>  PRT
<213>  Homo Sapiens

<400>  4291

Met Phe Asn Phe Asp Thr Phe Trp Lys Asn Phe Lys Ser Lys Leu Gly 
1               5                   10                  15      


Phe Ile Asn Trp Asp Ala Ile Asn Lys Asp Gln Arg Ser Ser Arg Ile 
            20                  25                  30          


Pro 
    


<210>  4292
<211>  95
<212>  PRT
<213>  Homo Sapiens

<400>  4292

Met Phe Asn Phe Asp Thr Phe Trp Lys Asn Phe Lys Ser Lys Leu Gly 
1               5                   10                  15      


Phe Ile Asn Trp Asp Ala Ile Asn Lys Asn Gln Val Pro Pro Pro Ser 
            20                  25                  30          


Thr Arg Ala Leu Leu Tyr Phe Ser Arg Leu Trp Glu Asp Phe Lys Gln 
        35                  40                  45              


Asn Thr Pro Phe Leu Asn Trp Lys Ala Ile Ile Glu Gly Ala Asp Ala 
    50                  55                  60                  


Ser Ser Leu Gln Lys Arg Ala Gly Arg Asp Asp Gln Asn Tyr Asn Tyr 
65                  70                  75                  80  


Asn Gln His Ala Tyr Pro Thr Ala Tyr Gly Gly Lys Tyr Ser Val 
                85                  90                  95  


<210>  4293
<211>  123
<212>  PRT
<213>  Homo Sapiens

<400>  4293

Met Phe Asn Phe Asp Thr Phe Trp Lys Asn Phe Lys Ser Lys Leu Gly 
1               5                   10                  15      


Phe Ile Asn Trp Asp Ala Ile Asn Lys Asn Gln Val Pro Pro Pro Ser 
            20                  25                  30          


Thr Arg Ala Leu Leu Tyr Phe Ser Arg Leu Trp Glu Asp Phe Lys Gln 
        35                  40                  45              


Asn Thr Pro Phe Leu Asn Trp Lys Ala Ile Ile Glu Gly Ala Asp Ala 
    50                  55                  60                  


Ser Ser Leu Gln Lys Arg Ala Gly Arg Asp Asp Gln Asn Tyr Asn Tyr 
65                  70                  75                  80  


Asn Gln His Ala Tyr Pro Thr Ala Tyr Gly Gly Lys Tyr Ser Val Lys 
                85                  90                  95      


Thr Pro Ala Lys Gly Gly Val Ser Pro Ser Ser Ser Ala Ser Arg Val 
            100                 105                 110         


Gln Pro Gly Leu Leu Gln Trp Val Lys Phe Trp 
        115                 120             


<210>  4294
<211>  123
<212>  PRT
<213>  Homo Sapiens

<400>  4294

Met Phe Asn Phe Asp Thr Phe Trp Lys Asn Phe Lys Ser Lys Leu Gly 
1               5                   10                  15      


Phe Ile Asn Trp Asp Ala Ile Asn Lys Asn Gln Val Pro Pro Pro Ser 
            20                  25                  30          


Thr Arg Ala Leu Leu Tyr Phe Ser Arg Leu Trp Glu Asp Phe Lys Gln 
        35                  40                  45              


Asn Thr Pro Phe Leu Asn Trp Lys Ala Ile Ile Glu Gly Ala Asp Ala 
    50                  55                  60                  


Ser Ser Leu Gln Lys Arg Ala Gly Arg Asp Asp Gln Asn Tyr Asn Tyr 
65                  70                  75                  80  


Asn Gln His Ala Tyr Pro Thr Ala Tyr Gly Gly Lys Tyr Ser Val Lys 
                85                  90                  95      


Thr Pro Ala Lys Gly Gly Val Ser Pro Ser Ser Ser Ala Ser Arg Val 
            100                 105                 110         


Gln Pro Gly Leu Leu Gln Trp Val Lys Phe Trp 
        115                 120             


<210>  4295
<211>  476
<212>  PRT
<213>  Homo Sapiens

<400>  4295

Met Lys Phe Gln Gly Pro Leu Ala Cys Leu Leu Leu Ala Leu Cys Leu 
1               5                   10                  15      


Gly Ser Gly Glu Ala Gly Pro Leu Gln Ser Gly Glu Glu Ser Thr Gly 
            20                  25                  30          


Thr Asn Ile Gly Glu Ala Leu Gly His Gly Leu Gly Asp Ala Leu Ser 
        35                  40                  45              


Glu Gly Val Gly Lys Ala Ile Gly Lys Glu Ala Gly Gly Ala Ala Gly 
    50                  55                  60                  


Ser Lys Val Ser Glu Ala Leu Gly Gln Gly Thr Arg Glu Ala Val Gly 
65                  70                  75                  80  


Thr Gly Val Arg Gln Val Pro Gly Phe Gly Val Ala Asp Ala Leu Gly 
                85                  90                  95      


Asn Arg Val Gly Glu Ala Ala His Ala Leu Gly Asn Thr Gly His Glu 
            100                 105                 110         


Ile Gly Arg Gln Ala Glu Asp Val Ile Arg His Gly Ala Asp Ala Val 
        115                 120                 125             


Arg Gly Ser Trp Gln Gly Val Pro Gly His Asn Gly Ala Trp Glu Thr 
    130                 135                 140                 


Ser Gly Gly His Gly Ile Phe Gly Ser Gln Gly Gly Leu Gly Gly Gln 
145                 150                 155                 160 


Gly Gln Gly Asn Pro Gly Gly Leu Gly Thr Pro Trp Val His Gly Tyr 
                165                 170                 175     


Pro Gly Asn Ser Ala Gly Ser Phe Gly Met Asn Pro Gln Gly Ala Pro 
            180                 185                 190         


Trp Gly Gln Gly Gly Asn Gly Gly Pro Pro Asn Phe Gly Thr Asn Thr 
        195                 200                 205             


Gln Gly Ala Val Ala Gln Pro Gly Tyr Gly Ser Val Arg Ala Ser Asn 
    210                 215                 220                 


Gln Asn Glu Gly Cys Thr Asn Pro Pro Pro Ser Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Ser Ser Asn Ser Gly Gly Gly Ser Gly Ser Gln Ser Gly Ser Ser Gly 
                245                 250                 255     


Ser Gly Ser Asn Gly Asp Asn Asn Asn Gly Ser Ser Ser Gly Gly Ser 
            260                 265                 270         


Ser Ser Gly Ser Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly 
        275                 280                 285             


Ser Ser Gly Asn Ser Gly Gly Ser Arg Gly Asp Ser Gly Ser Glu Ser 
    290                 295                 300                 


Ser Trp Gly Ser Ser Thr Gly Ser Ser Ser Gly Asn His Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Gly Asn Gly His Lys Pro Gly Cys Glu Lys Pro Gly Asn Glu 
                325                 330                 335     


Ala Arg Gly Ser Gly Glu Ser Gly Ile Gln Asn Ser Glu Thr Ser Pro 
            340                 345                 350         


Gly Met Phe Asn Phe Asp Thr Phe Trp Lys Asn Phe Lys Ser Lys Leu 
        355                 360                 365             


Gly Phe Ile Asn Trp Asp Ala Ile Asn Lys Asn Gln Val Pro Pro Pro 
    370                 375                 380                 


Ser Thr Arg Ala Leu Leu Tyr Phe Ser Arg Leu Trp Glu Asp Phe Lys 
385                 390                 395                 400 


Gln Asn Thr Pro Phe Leu Asn Trp Lys Ala Ile Ile Glu Gly Ala Asp 
                405                 410                 415     


Ala Ser Ser Leu Gln Lys Arg Ala Gly Arg Asp Asp Gln Asn Tyr Asn 
            420                 425                 430         


Tyr Asn Gln His Ala Tyr Pro Thr Ala Tyr Gly Gly Lys Tyr Ser Val 
        435                 440                 445             


Lys Thr Pro Ala Lys Gly Gly Val Ser Pro Ser Ser Ser Ala Ser Arg 
    450                 455                 460                 


Val Gln Pro Gly Leu Leu Gln Trp Val Lys Phe Trp 
465                 470                 475     


<210>  4296
<211>  386
<212>  PRT
<213>  Homo Sapiens

<400>  4296

Met Lys Phe Gln Gly Pro Leu Ala Cys Leu Leu Leu Ala Leu Cys Leu 
1               5                   10                  15      


Gly Ser Gly Glu Ala Gly Pro Leu Gln Ser Gly Glu Glu Ser Thr Gly 
            20                  25                  30          


Thr Asn Ile Gly Glu Ala Leu Gly His Gly Leu Gly Asp Ala Leu Ser 
        35                  40                  45              


Glu Gly Val Gly Lys Ala Ile Gly Lys Glu Ala Gly Gly Ala Ala Gly 
    50                  55                  60                  


Ser Lys Val Ser Glu Ala Leu Gly Gln Gly Thr Arg Glu Ala Val Gly 
65                  70                  75                  80  


Thr Gly Val Arg Gln Val Pro Gly Phe Gly Val Ala Asp Ala Leu Gly 
                85                  90                  95      


Asn Arg Val Gly Glu Ala Ala His Ala Leu Gly Asn Thr Gly His Glu 
            100                 105                 110         


Ile Gly Arg Gln Ala Glu Asp Val Ile Arg His Gly Ala Asp Ala Val 
        115                 120                 125             


Arg Gly Ser Trp Gln Gly Val Pro Gly His Asn Gly Ala Trp Glu Thr 
    130                 135                 140                 


Ser Gly Gly His Gly Ile Phe Gly Ser Gln Gly Gly Leu Gly Gly Gln 
145                 150                 155                 160 


Gly Gln Gly Asn Pro Gly Gly Leu Gly Thr Pro Trp Val His Gly Tyr 
                165                 170                 175     


Pro Gly Asn Ser Ala Gly Ser Phe Gly Met Asn Pro Gln Gly Ala Pro 
            180                 185                 190         


Trp Gly Gln Gly Gly Asn Gly Gly Pro Pro Asn Phe Gly Thr Asn Thr 
        195                 200                 205             


Gln Gly Ala Val Ala Gln Pro Gly Tyr Gly Ser Val Arg Ala Ser Asn 
    210                 215                 220                 


Gln Asn Glu Gly Cys Thr Asn Pro Pro Pro Ser Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Ser Ser Asn Ser Gly Gly Gly Ser Gly Ser Gln Ser Gly Ser Ser Gly 
                245                 250                 255     


Ser Gly Ser Asn Gly Asp Asn Asn Asn Gly Ser Ser Ser Gly Gly Ser 
            260                 265                 270         


Ser Ser Gly Ser Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly 
        275                 280                 285             


Ser Ser Gly Asn Ser Gly Gly Ser Arg Gly Asp Ser Gly Ser Glu Ser 
    290                 295                 300                 


Ser Trp Gly Ser Ser Thr Gly Ser Ser Ser Gly Asn His Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Gly Asn Gly His Lys Pro Gly Cys Glu Lys Pro Gly Asn Glu 
                325                 330                 335     


Ala Arg Gly Ser Gly Glu Ser Gly Ile Gln Asn Ser Glu Thr Ser Pro 
            340                 345                 350         


Gly Met Phe Asn Phe Asp Thr Phe Trp Lys Asn Phe Lys Ser Lys Leu 
        355                 360                 365             


Gly Phe Ile Asn Trp Asp Ala Ile Asn Lys Asp Gln Arg Ser Ser Arg 
    370                 375                 380                 


Ile Pro 
385     


<210>  4297
<211>  436
<212>  PRT
<213>  Homo Sapiens

<400>  4297

Met Lys Phe Gln Gly Pro Leu Ala Cys Leu Leu Leu Ala Leu Cys Leu 
1               5                   10                  15      


Gly Ser Gly Glu Ala Gly Pro Leu Gln Ser Gly Glu Glu Ser Thr Gly 
            20                  25                  30          


Thr Asn Ile Gly Glu Ala Leu Gly His Gly Leu Gly Asp Ala Leu Ser 
        35                  40                  45              


Glu Gly Val Gly Lys Ala Ile Gly Lys Glu Ala Gly Gly Ala Ala Gly 
    50                  55                  60                  


Ser Lys Val Ser Glu Ala Leu Gly Gln Gly Thr Arg Glu Ala Val Gly 
65                  70                  75                  80  


Thr Gly Val Arg Gln Val Pro Gly Phe Gly Val Ala Asp Ala Leu Gly 
                85                  90                  95      


Asn Arg Val Gly Glu Ala Ala His Ala Leu Gly Asn Thr Gly His Glu 
            100                 105                 110         


Ile Gly Arg Gln Ala Glu Asp Val Ile Arg His Gly Ala Asp Ala Val 
        115                 120                 125             


Arg Gly Ser Trp Gln Gly Val Pro Gly His Asn Gly Ala Trp Glu Thr 
    130                 135                 140                 


Ser Gly Gly His Gly Ile Phe Gly Ser Gln Gly Gly Leu Gly Gly Gln 
145                 150                 155                 160 


Gly Gln Gly Asn Pro Gly Gly Leu Gly Thr Pro Trp Val His Gly Tyr 
                165                 170                 175     


Pro Gly Asn Ser Ala Gly Ser Phe Gly Met Asn Pro Gln Gly Ala Pro 
            180                 185                 190         


Trp Gly Gln Gly Gly Asn Gly Gly Pro Pro Asn Phe Gly Thr Asn Thr 
        195                 200                 205             


Gln Gly Ala Val Ala Gln Pro Gly Tyr Gly Ser Val Arg Ala Ser Asn 
    210                 215                 220                 


Gln Asn Glu Gly Cys Thr Asn Pro Pro Pro Ser Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Ser Ser Asn Ser Gly Gly Gly Ser Gly Ser Gln Ser Gly Ser Ser Gly 
                245                 250                 255     


Ser Gly Ser Asn Gly Asp Asn Asn Asn Gly Ser Ser Ser Gly Gly Ser 
            260                 265                 270         


Ser Ser Gly Ser Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly 
        275                 280                 285             


Ser Ser Gly Asn Ser Gly Gly Ser Arg Gly Asp Ser Gly Ser Glu Ser 
    290                 295                 300                 


Ser Trp Gly Ser Ser Thr Gly Ser Ser Ser Gly Asn His Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Gly Asn Gly His Lys Pro Gly Cys Glu Lys Pro Gly Asn Glu 
                325                 330                 335     


Ala Arg Gly Ser Gly Glu Ser Gly Ile Gln Gly Phe Arg Gly Gln Gly 
            340                 345                 350         


Val Ser Ser Asn Met Arg Glu Ile Ser Lys Glu Gly Asn Arg Leu Leu 
        355                 360                 365             


Gly Gly Ser Gly Asp Asn Tyr Arg Gly Gln Gly Ser Ser Trp Gly Ser 
    370                 375                 380                 


Gly Gly Gly Asp Ala Val Gly Gly Val Asn Thr Val Asn Ser Glu Thr 
385                 390                 395                 400 


Ser Pro Gly Met Phe Asn Phe Asp Thr Phe Trp Lys Asn Phe Lys Ser 
                405                 410                 415     


Lys Leu Gly Phe Ile Asn Trp Asp Ala Ile Asn Lys Asp Gln Arg Ser 
            420                 425                 430         


Ser Arg Ile Pro 
        435     


<210>  4298
<211>  398
<212>  PRT
<213>  Homo Sapiens

<400>  4298

Met Lys Phe Gln Gly Pro Leu Ala Cys Leu Leu Leu Ala Leu Cys Leu 
1               5                   10                  15      


Gly Ser Gly Glu Ala Gly Pro Leu Gln Ser Gly Glu Glu Ser Thr Gly 
            20                  25                  30          


Thr Asn Ile Gly Glu Ala Leu Gly His Gly Leu Gly Asp Ala Leu Ser 
        35                  40                  45              


Glu Gly Val Gly Lys Ala Ile Gly Lys Glu Ala Gly Gly Ala Ala Gly 
    50                  55                  60                  


Ser Lys Val Ser Glu Ala Leu Gly Gln Gly Thr Arg Glu Ala Val Gly 
65                  70                  75                  80  


Thr Gly Val Arg Gln Val Pro Gly Phe Gly Val Ala Asp Ala Leu Gly 
                85                  90                  95      


Asn Arg Val Gly Glu Ala Ala His Ala Leu Gly Asn Thr Gly His Glu 
            100                 105                 110         


Ile Gly Arg Gln Ala Glu Asp Val Ile Arg His Gly Ala Asp Ala Val 
        115                 120                 125             


Arg Gly Ser Trp Gln Gly Val Pro Gly His Asn Gly Ala Trp Glu Thr 
    130                 135                 140                 


Ser Gly Gly His Gly Ile Phe Gly Ser Gln Gly Gly Leu Gly Gly Gln 
145                 150                 155                 160 


Gly Gln Gly Asn Pro Gly Gly Leu Gly Thr Pro Trp Val His Gly Tyr 
                165                 170                 175     


Pro Gly Asn Ser Ala Gly Ser Phe Gly Met Asn Pro Gln Gly Ala Pro 
            180                 185                 190         


Trp Gly Gln Gly Gly Asn Gly Gly Pro Pro Asn Phe Gly Thr Asn Thr 
        195                 200                 205             


Gln Gly Ala Val Ala Gln Pro Gly Tyr Gly Ser Val Arg Ala Ser Asn 
    210                 215                 220                 


Gln Asn Glu Gly Cys Thr Asn Pro Pro Pro Ser Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Ser Ser Asn Ser Gly Gly Gly Ser Gly Ser Gln Ser Gly Ser Ser Gly 
                245                 250                 255     


Ser Gly Ser Asn Gly Asp Asn Asn Asn Gly Ser Ser Ser Gly Gly Ser 
            260                 265                 270         


Ser Ser Gly Ser Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly 
        275                 280                 285             


Ser Ser Gly Asn Ser Gly Gly Ser Arg Gly Asp Ser Gly Ser Glu Ser 
    290                 295                 300                 


Ser Trp Gly Ser Ser Thr Gly Ser Ser Ser Gly Asn His Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Gly Asn Gly His Lys Pro Gly Cys Glu Lys Pro Gly Asn Glu 
                325                 330                 335     


Ala Arg Gly Ser Gly Glu Ser Gly Ile Gln Gly Phe Arg Gly Gln Gly 
            340                 345                 350         


Val Ser Ser Asn Met Arg Asn Ser Glu Thr Ser Pro Gly Met Phe Asn 
        355                 360                 365             


Phe Asp Thr Phe Trp Lys Asn Phe Lys Ser Lys Leu Gly Phe Ile Asn 
    370                 375                 380                 


Trp Asp Ala Ile Asn Lys Asp Gln Arg Ser Ser Arg Ile Pro 
385                 390                 395             


<210>  4299
<211>  369
<212>  PRT
<213>  Homo Sapiens

<400>  4299

Met Lys Phe Gln Gly Pro Leu Ala Cys Leu Leu Leu Ala Leu Cys Leu 
1               5                   10                  15      


Gly Ser Gly Glu Ala Gly Pro Leu Gln Ser Gly Glu Glu Ser Thr Gly 
            20                  25                  30          


Thr Asn Ile Gly Glu Ala Leu Gly His Gly Leu Gly Asp Ala Leu Ser 
        35                  40                  45              


Glu Gly Val Gly Lys Ala Ile Gly Lys Glu Ala Gly Gly Ala Ala Gly 
    50                  55                  60                  


Ser Lys Val Ser Glu Ala Leu Gly Gln Gly Thr Arg Glu Ala Val Gly 
65                  70                  75                  80  


Thr Gly Val Arg Gln Val Pro Gly Phe Gly Val Ala Asp Ala Leu Gly 
                85                  90                  95      


Asn Arg Val Gly Glu Ala Ala His Ala Leu Gly Asn Thr Gly His Glu 
            100                 105                 110         


Ile Gly Arg Gln Ala Glu Asp Val Ile Arg His Gly Ala Asp Ala Val 
        115                 120                 125             


Arg Gly Ser Trp Gln Gly Val Pro Gly His Asn Gly Ala Trp Glu Thr 
    130                 135                 140                 


Ser Gly Gly His Gly Ile Phe Gly Ser Gln Gly Gly Leu Gly Gly Gln 
145                 150                 155                 160 


Gly Gln Gly Asn Pro Gly Gly Leu Gly Thr Pro Trp Val His Gly Tyr 
                165                 170                 175     


Pro Gly Asn Ser Ala Gly Ser Phe Gly Met Asn Pro Gln Gly Ala Pro 
            180                 185                 190         


Trp Gly Gln Gly Gly Asn Gly Gly Pro Pro Asn Phe Gly Thr Asn Thr 
        195                 200                 205             


Gln Gly Ala Val Ala Gln Pro Gly Tyr Gly Ser Val Arg Ala Ser Asn 
    210                 215                 220                 


Gln Asn Glu Gly Cys Thr Asn Pro Pro Pro Ser Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Ser Ser Asn Ser Gly Gly Gly Ser Gly Ser Gln Ser Gly Ser Ser Gly 
                245                 250                 255     


Ser Gly Ser Asn Gly Asp Asn Asn Asn Gly Ser Ser Ser Gly Gly Ser 
            260                 265                 270         


Ser Ser Gly Ser Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly 
        275                 280                 285             


Ser Ser Gly Asn Ser Gly Gly Ser Arg Gly Asp Ser Gly Ser Glu Ser 
    290                 295                 300                 


Ser Trp Gly Ser Ser Thr Gly Ser Ser Ser Gly Asn His Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Gly Asn Gly His Lys Pro Gly Asn Ser Glu Thr Ser Pro Gly 
                325                 330                 335     


Met Phe Asn Phe Asp Thr Phe Trp Lys Asn Phe Lys Ser Lys Leu Gly 
            340                 345                 350         


Phe Ile Asn Trp Asp Ala Ile Asn Lys Asp Gln Arg Ser Ser Arg Ile 
        355                 360                 365             


Pro 
    


<210>  4300
<211>  449
<212>  PRT
<213>  Homo Sapiens

<400>  4300

Met Lys Phe Gln Gly Pro Leu Ala Cys Leu Leu Leu Ala Leu Cys Leu 
1               5                   10                  15      


Gly Ser Gly Glu Ala Gly Pro Leu Gln Ser Gly Glu Glu Ser Thr Gly 
            20                  25                  30          


Thr Asn Ile Gly Glu Ala Leu Gly His Gly Leu Gly Asp Ala Leu Ser 
        35                  40                  45              


Glu Gly Val Gly Lys Ala Ile Gly Lys Glu Ala Gly Gly Ala Ala Gly 
    50                  55                  60                  


Ser Lys Val Ser Glu Ala Leu Gly Gln Gly Thr Arg Glu Ala Val Gly 
65                  70                  75                  80  


Thr Gly Val Arg Gln Val Pro Gly Phe Gly Val Ala Asp Ala Leu Gly 
                85                  90                  95      


Asn Arg Val Gly Glu Ala Ala His Ala Leu Gly Asn Thr Gly His Glu 
            100                 105                 110         


Ile Gly Arg Gln Ala Glu Asp Val Ile Arg His Gly Ala Asp Ala Val 
        115                 120                 125             


Arg Gly Ser Trp Gln Gly Val Pro Gly His Asn Gly Ala Trp Glu Thr 
    130                 135                 140                 


Ser Gly Gly His Gly Ile Phe Gly Ser Gln Gly Gly Leu Gly Gly Gln 
145                 150                 155                 160 


Gly Gln Gly Asn Pro Gly Gly Leu Gly Thr Pro Trp Val His Gly Tyr 
                165                 170                 175     


Pro Gly Asn Ser Ala Gly Ser Phe Gly Met Asn Pro Gln Gly Ala Pro 
            180                 185                 190         


Trp Gly Gln Gly Gly Asn Gly Gly Pro Pro Asn Phe Gly Thr Asn Thr 
        195                 200                 205             


Gln Gly Ala Val Ala Gln Pro Gly Tyr Gly Ser Val Arg Ala Ser Asn 
    210                 215                 220                 


Gln Asn Glu Gly Cys Thr Asn Pro Pro Pro Ser Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Ser Ser Asn Ser Gly Gly Ser Ser Thr Gly Ser Ser Ser Gly Asn His 
                245                 250                 255     


Gly Gly Ser Gly Gly Gly Asn Gly His Lys Pro Gly Cys Glu Lys Pro 
            260                 265                 270         


Gly Asn Glu Ala Arg Gly Ser Gly Glu Ser Gly Ile Gln Gly Gln Gly 
        275                 280                 285             


Ser Ser Trp Gly Ser Gly Gly Gly Asp Ala Val Gly Gly Val Asn Thr 
    290                 295                 300                 


Val Asn Ser Glu Thr Ser Pro Gly Met Phe Asn Phe Asp Thr Phe Trp 
305                 310                 315                 320 


Lys Asn Phe Lys Ser Lys Leu Gly Phe Ile Asn Trp Asp Ala Ile Asn 
                325                 330                 335     


Lys Asn Gln Val Pro Pro Pro Ser Thr Arg Ala Leu Leu Tyr Phe Ser 
            340                 345                 350         


Arg Leu Trp Glu Asp Phe Lys Gln Asn Thr Pro Phe Leu Asn Trp Lys 
        355                 360                 365             


Ala Ile Ile Glu Gly Ala Asp Ala Ser Ser Leu Gln Lys Arg Ala Gly 
    370                 375                 380                 


Arg Asp Asp Gln Pro Gly Ala Gly Trp Gln Glu Val Ala Ala Val Thr 
385                 390                 395                 400 


Ser Lys Asn Tyr Asn Tyr Asn Gln His Ala Tyr Pro Thr Ala Tyr Gly 
                405                 410                 415     


Gly Lys Tyr Ser Val Lys Thr Pro Ala Lys Gly Gly Val Ser Pro Ser 
            420                 425                 430         


Ser Ser Ala Ser Arg Val Gln Pro Gly Leu Leu Gln Trp Val Lys Phe 
        435                 440                 445             


Trp 
    


<210>  4301
<211>  465
<212>  PRT
<213>  Homo Sapiens

<400>  4301

Met Lys Phe Gln Gly Pro Leu Ala Cys Leu Leu Leu Ala Leu Cys Leu 
1               5                   10                  15      


Gly Ser Gly Glu Ala Gly Pro Leu Gln Ser Gly Glu Glu Ser Thr Gly 
            20                  25                  30          


Thr Asn Ile Gly Glu Ala Leu Gly His Gly Leu Gly Asp Ala Leu Ser 
        35                  40                  45              


Glu Gly Val Gly Lys Ala Ile Gly Lys Glu Ala Gly Gly Ala Ala Gly 
    50                  55                  60                  


Ser Lys Val Ser Glu Ala Leu Gly Gln Gly Thr Arg Glu Ala Val Gly 
65                  70                  75                  80  


Thr Gly Val Arg Gln Val Pro Gly Phe Gly Val Ala Asp Ala Leu Gly 
                85                  90                  95      


Asn Arg Val Gly Glu Ala Ala His Ala Leu Gly Asn Thr Gly His Glu 
            100                 105                 110         


Ile Gly Arg Gln Ala Glu Asp Val Ile Arg His Gly Ala Asp Ala Val 
        115                 120                 125             


Arg Gly Ser Trp Gln Gly Val Pro Gly His Asn Gly Ala Trp Glu Thr 
    130                 135                 140                 


Ser Gly Gly His Gly Ile Phe Gly Ser Gln Gly Gly Leu Gly Gly Gln 
145                 150                 155                 160 


Gly Gln Gly Asn Pro Gly Gly Leu Gly Thr Pro Trp Val His Gly Tyr 
                165                 170                 175     


Pro Gly Asn Ser Ala Gly Ser Phe Gly Met Asn Pro Gln Gly Ala Pro 
            180                 185                 190         


Trp Gly Gln Gly Gly Asn Gly Gly Pro Pro Asn Phe Gly Thr Asn Thr 
        195                 200                 205             


Gln Gly Ala Val Ala Gln Pro Gly Tyr Gly Ser Val Arg Ala Ser Asn 
    210                 215                 220                 


Gln Asn Glu Gly Cys Thr Asn Pro Pro Pro Ser Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Ser Ser Asn Ser Gly Gly Ser Ser Thr Gly Ser Ser Ser Gly Asn His 
                245                 250                 255     


Gly Gly Ser Gly Gly Gly Asn Gly His Lys Pro Gly Cys Glu Lys Pro 
            260                 265                 270         


Gly Asn Glu Ala Arg Gly Ser Gly Glu Ser Gly Ile Gln Gly Phe Arg 
        275                 280                 285             


Gly Gln Gly Val Ser Ser Asn Met Arg Glu Ile Ser Lys Glu Gly Asn 
    290                 295                 300                 


Arg Leu Leu Gly Gly Ser Gly Asp Asn Tyr Arg Gly Gln Gly Ser Ser 
305                 310                 315                 320 


Trp Gly Ser Gly Gly Gly Asp Ala Val Gly Gly Val Asn Thr Val Asn 
                325                 330                 335     


Ser Glu Thr Ser Pro Gly Met Phe Asn Phe Asp Thr Phe Trp Lys Asn 
            340                 345                 350         


Phe Lys Ser Lys Leu Gly Phe Ile Asn Trp Asp Ala Ile Asn Lys Asn 
        355                 360                 365             


Gln Val Pro Pro Pro Ser Thr Arg Ala Leu Leu Tyr Phe Ser Arg Leu 
    370                 375                 380                 


Trp Glu Asp Phe Lys Gln Asn Thr Pro Phe Leu Asn Trp Lys Ala Ile 
385                 390                 395                 400 


Ile Glu Gly Ala Asp Ala Ser Ser Leu Gln Lys Arg Ala Gly Arg Asp 
                405                 410                 415     


Asp Gln Asn Tyr Asn Tyr Asn Gln His Ala Tyr Pro Thr Ala Tyr Gly 
            420                 425                 430         


Gly Lys Tyr Ser Val Lys Thr Pro Ala Lys Gly Gly Val Ser Pro Ser 
        435                 440                 445             


Ser Ser Ala Ser Arg Val Gln Pro Gly Leu Leu Gln Trp Val Lys Phe 
    450                 455                 460                 


Trp 
465 


<210>  4302
<211>  36
<212>  PRT
<213>  Homo Sapiens

<400>  4302

Met Leu Gly Ile Thr Ser Cys Ser Asp Gln Gln Ala Lys Glu Gly Glu 
1               5                   10                  15      


Gly Ile Gln His Arg Leu Leu Leu Arg Gln Pro Arg Trp Glu Arg Arg 
            20                  25                  30          


Arg Lys Trp Thr 
        35      


<210>  4303
<211>  36
<212>  PRT
<213>  Homo Sapiens

<400>  4303

Met Leu Gly Ile Thr Ser Cys Ser Asp Gln Gln Ala Lys Glu Gly Glu 
1               5                   10                  15      


Gly Ile Gln His Arg Leu Leu Leu Arg Gln Pro Arg Trp Glu Arg Arg 
            20                  25                  30          


Arg Lys Trp Thr 
        35      


<210>  4304
<211>  36
<212>  PRT
<213>  Homo Sapiens

<400>  4304

Met Leu Gly Ile Thr Ser Cys Ser Asp Gln Gln Ala Lys Glu Gly Glu 
1               5                   10                  15      


Gly Ile Gln His Arg Leu Leu Leu Arg Gln Pro Arg Trp Glu Arg Arg 
            20                  25                  30          


Arg Lys Trp Thr 
        35      


<210>  4305
<211>  36
<212>  PRT
<213>  Homo Sapiens

<400>  4305

Met Leu Gly Ile Thr Ser Cys Ser Asp Gln Gln Ala Lys Glu Gly Glu 
1               5                   10                  15      


Gly Ile Gln His Arg Leu Leu Leu Arg Gln Pro Arg Trp Glu Arg Arg 
            20                  25                  30          


Arg Lys Trp Thr 
        35      


<210>  4306
<211>  36
<212>  PRT
<213>  Homo Sapiens

<400>  4306

Met Leu Gly Ile Thr Ser Cys Ser Asp Gln Gln Ala Lys Glu Gly Glu 
1               5                   10                  15      


Gly Ile Gln His Arg Leu Leu Leu Arg Gln Pro Arg Trp Glu Arg Arg 
            20                  25                  30          


Arg Lys Trp Thr 
        35      


<210>  4307
<211>  36
<212>  PRT
<213>  Homo Sapiens

<400>  4307

Met Leu Gly Ile Thr Ser Cys Ser Asp Gln Gln Ala Lys Glu Gly Glu 
1               5                   10                  15      


Gly Ile Gln His Arg Leu Leu Leu Arg Gln Pro Arg Trp Glu Arg Arg 
            20                  25                  30          


Arg Lys Trp Thr 
        35      


<210>  4308
<211>  36
<212>  PRT
<213>  Homo Sapiens

<400>  4308

Met Leu Gly Ile Thr Ser Cys Ser Asp Gln Gln Ala Lys Glu Gly Glu 
1               5                   10                  15      


Gly Ile Gln His Arg Leu Leu Leu Arg Gln Pro Arg Trp Glu Arg Arg 
            20                  25                  30          


Arg Lys Trp Thr 
        35      


<210>  4309
<211>  36
<212>  PRT
<213>  Homo Sapiens

<400>  4309

Met Leu Gly Ile Thr Ser Cys Ser Asp Gln Gln Ala Lys Glu Gly Glu 
1               5                   10                  15      


Gly Ile Gln His Arg Leu Leu Leu Arg Gln Pro Arg Trp Glu Arg Arg 
            20                  25                  30          


Arg Lys Trp Thr 
        35      


<210>  4310
<211>  36
<212>  PRT
<213>  Homo Sapiens

<400>  4310

Met Leu Gly Ile Thr Ser Cys Ser Asp Gln Gln Ala Lys Glu Gly Glu 
1               5                   10                  15      


Gly Ile Gln His Arg Leu Leu Leu Arg Gln Pro Arg Trp Glu Arg Arg 
            20                  25                  30          


Arg Lys Trp Thr 
        35      


<210>  4311
<211>  36
<212>  PRT
<213>  Homo Sapiens

<400>  4311

Met Leu Gly Ile Thr Ser Cys Ser Asp Gln Gln Ala Lys Glu Gly Glu 
1               5                   10                  15      


Gly Ile Gln His Arg Leu Leu Leu Arg Gln Pro Arg Trp Glu Arg Arg 
            20                  25                  30          


Arg Lys Trp Thr 
        35      


<210>  4312
<211>  36
<212>  PRT
<213>  Homo Sapiens

<400>  4312

Met Leu Gly Ile Thr Ser Cys Ser Asp Gln Gln Ala Lys Glu Gly Glu 
1               5                   10                  15      


Gly Ile Gln His Arg Leu Leu Leu Arg Gln Pro Arg Trp Glu Arg Arg 
            20                  25                  30          


Arg Lys Trp Thr 
        35      


<210>  4313
<211>  36
<212>  PRT
<213>  Homo Sapiens

<400>  4313

Met Leu Gly Ile Thr Ser Cys Ser Asp Gln Gln Ala Lys Glu Gly Glu 
1               5                   10                  15      


Gly Ile Gln His Arg Leu Leu Leu Arg Gln Pro Arg Trp Glu Arg Arg 
            20                  25                  30          


Arg Lys Trp Thr 
        35      


<210>  4314
<211>  36
<212>  PRT
<213>  Homo Sapiens

<400>  4314

Met Leu Gly Ile Thr Ser Cys Ser Asp Gln Gln Ala Lys Glu Gly Glu 
1               5                   10                  15      


Gly Ile Gln His Arg Leu Leu Leu Arg Gln Pro Arg Trp Glu Arg Arg 
            20                  25                  30          


Arg Lys Trp Thr 
        35      


<210>  4315
<211>  36
<212>  PRT
<213>  Homo Sapiens

<400>  4315

Met Leu Gly Ile Thr Ser Cys Ser Asp Gln Gln Ala Lys Glu Gly Glu 
1               5                   10                  15      


Gly Ile Gln His Arg Leu Leu Leu Arg Gln Pro Arg Trp Glu Arg Arg 
            20                  25                  30          


Arg Lys Trp Thr 
        35      


<210>  4316
<211>  36
<212>  PRT
<213>  Homo Sapiens

<400>  4316

Met Leu Gly Ile Thr Ser Cys Ser Asp Gln Gln Ala Lys Glu Gly Glu 
1               5                   10                  15      


Gly Ile Gln His Arg Leu Leu Leu Arg Gln Pro Arg Trp Glu Arg Arg 
            20                  25                  30          


Arg Lys Trp Thr 
        35      


<210>  4317
<211>  36
<212>  PRT
<213>  Homo Sapiens

<400>  4317

Met Leu Gly Ile Thr Ser Cys Ser Asp Gln Gln Ala Lys Glu Gly Glu 
1               5                   10                  15      


Gly Ile Gln His Arg Leu Leu Leu Arg Gln Pro Arg Trp Glu Arg Arg 
            20                  25                  30          


Arg Lys Trp Thr 
        35      


<210>  4318
<211>  36
<212>  PRT
<213>  Homo Sapiens

<400>  4318

Met Leu Gly Ile Thr Ser Cys Ser Asp Gln Gln Ala Lys Glu Gly Glu 
1               5                   10                  15      


Gly Ile Gln His Arg Leu Leu Leu Arg Gln Pro Arg Trp Glu Arg Arg 
            20                  25                  30          


Arg Lys Trp Thr 
        35      


<210>  4319
<211>  253
<212>  PRT
<213>  Homo Sapiens

<400>  4319

Met Leu Gly Ile Thr Ser Cys Ser Asp Gln Gln Ala Lys Glu Gly Glu 
1               5                   10                  15      


Gly Leu Glu Gly Ser Ser Thr Gly Ser Ser Ser Gly Asn His Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Asn Gly His Lys Pro Gly Cys Glu Lys Pro Gly Asn 
        35                  40                  45              


Glu Ala Arg Gly Ser Gly Glu Ser Gly Ile Gln Gly Phe Arg Gly Gln 
    50                  55                  60                  


Gly Val Ser Ser Asn Met Arg Glu Ile Ser Lys Glu Gly Asn Arg Leu 
65                  70                  75                  80  


Leu Gly Gly Ser Gly Asp Asn Tyr Arg Gly Gln Gly Ser Ser Trp Gly 
                85                  90                  95      


Ser Gly Gly Gly Asp Ala Val Gly Gly Val Asn Thr Val Asn Ser Glu 
            100                 105                 110         


Thr Ser Pro Gly Met Phe Asn Phe Asp Thr Phe Trp Lys Asn Phe Lys 
        115                 120                 125             


Ser Lys Leu Gly Phe Ile Asn Trp Asp Ala Ile Asn Lys Asn Gln Val 
    130                 135                 140                 


Pro Pro Pro Ser Thr Arg Ala Leu Leu Tyr Phe Ser Arg Leu Trp Glu 
145                 150                 155                 160 


Asp Phe Lys Gln Asn Thr Pro Phe Leu Asn Trp Lys Ala Ile Ile Glu 
                165                 170                 175     


Gly Ala Asp Ala Ser Ser Leu Gln Lys Arg Ala Gly Arg Asp Asp Gln 
            180                 185                 190         


Pro Gly Ala Gly Trp Gln Glu Val Ala Ala Val Thr Ser Lys Asn Tyr 
        195                 200                 205             


Asn Tyr Asn Gln His Ala Tyr Pro Thr Ala Tyr Gly Gly Lys Tyr Ser 
    210                 215                 220                 


Val Lys Thr Pro Ala Lys Gly Gly Val Ser Pro Ser Ser Ser Ala Ser 
225                 230                 235                 240 


Arg Val Gln Pro Gly Leu Leu Gln Trp Val Lys Phe Trp 
                245                 250             


<210>  4320
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  4320

Met Leu Gly Ile Thr Ser Cys Ser Asp Gln Gln Ala Lys Glu Gly Glu 
1               5                   10                  15      


Gly Leu Glu Gly Ser Ser Thr Gly Ser Ser Ser Gly Asn His Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Asn Gly His Lys Pro Gly Cys Glu Lys Pro Gly Asn 
        35                  40                  45              


Glu Ala Arg Gly Ser Gly Glu Ser Gly Ile Gln Gly Phe Arg Gly Gln 
    50                  55                  60                  


Gly Val Ser Ser Asn Met Arg Gly Gln Gly Ser Ser Trp Gly Ser Gly 
65                  70                  75                  80  


Gly Gly Asp Ala Val Gly Gly Val Asn Thr Val Asn Ser Glu Thr Ser 
                85                  90                  95      


Pro Gly Met Phe Asn Phe Asp Thr Phe Trp Lys Asn Phe Lys Ser Lys 
            100                 105                 110         


Leu Gly Phe Ile Asn Trp Asp Ala Ile Asn Lys Asp Gln Arg Ser Ser 
        115                 120                 125             


Arg Ile Pro 
    130     


<210>  4321
<211>  201
<212>  PRT
<213>  Homo Sapiens

<400>  4321

Met Leu Gly Ile Thr Ser Cys Ser Asp Gln Gln Ala Lys Glu Gly Glu 
1               5                   10                  15      


Gly Leu Glu Gly Ser Ser Thr Gly Ser Ser Ser Gly Asn His Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Asn Gly His Lys Pro Gly Cys Glu Lys Pro Gly Asn 
        35                  40                  45              


Glu Ala Arg Gly Ser Gly Glu Ser Gly Ile Gln Gly Phe Arg Gly Gln 
    50                  55                  60                  


Gly Val Ser Ser Asn Met Arg Asn Ser Glu Thr Ser Pro Gly Met Phe 
65                  70                  75                  80  


Asn Phe Asp Thr Phe Trp Lys Asn Phe Lys Ser Lys Leu Gly Phe Ile 
                85                  90                  95      


Asn Trp Asp Ala Ile Asn Lys Asn Gln Val Pro Pro Pro Ser Thr Arg 
            100                 105                 110         


Ala Leu Leu Tyr Phe Ser Arg Leu Trp Glu Asp Phe Lys Gln Asn Thr 
        115                 120                 125             


Pro Phe Leu Asn Trp Lys Ala Ile Ile Glu Gly Ala Asp Ala Ser Ser 
    130                 135                 140                 


Leu Gln Lys Arg Ala Gly Arg Asp Asp Gln Asn Tyr Asn Tyr Asn Gln 
145                 150                 155                 160 


His Ala Tyr Pro Thr Ala Tyr Gly Gly Lys Tyr Ser Val Lys Thr Pro 
                165                 170                 175     


Ala Lys Gly Gly Val Ser Pro Ser Ser Ser Ala Ser Arg Val Gln Pro 
            180                 185                 190         


Gly Leu Leu Gln Trp Val Lys Phe Trp 
        195                 200     


<210>  4322
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  4322

Met Leu Gly Ile Thr Ser Cys Ser Asp Gln Gln Ala Lys Glu Gly Glu 
1               5                   10                  15      


Gly Leu Glu Gly Ser Ser Thr Gly Ser Ser Ser Gly Asn His Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Asn Gly His Lys Pro Gly Cys Glu Lys Pro Gly Asn 
        35                  40                  45              


Glu Ala Arg Gly Ser Gly Glu Ser Gly Ile Gln Gly Gln Gly Ser Ser 
    50                  55                  60                  


Trp Gly Ser Gly Gly Gly Asp Ala Val Gly Gly Val Asn Thr Val Asn 
65                  70                  75                  80  


Ser Glu Thr Ser Pro Gly Met Phe Asn Phe Asp Thr Phe Trp Lys Asn 
                85                  90                  95      


Phe Lys Ser Lys Leu Gly Phe Ile Asn Trp Asp Ala Ile Asn Lys Asp 
            100                 105                 110         


Gln Arg Ser Ser 
        115     


<210>  4323
<211>  184
<212>  PRT
<213>  Homo Sapiens

<400>  4323

Met Leu Gly Ile Thr Ser Cys Ser Asp Gln Gln Ala Lys Glu Gly Glu 
1               5                   10                  15      


Gly Leu Glu Gly Ser Ser Thr Gly Ser Ser Ser Gly Asn His Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Asn Gly His Lys Pro Gly Cys Glu Lys Pro Gly Asn 
        35                  40                  45              


Glu Ala Arg Gly Ser Gly Glu Ser Gly Ile Gln Asn Ser Glu Thr Ser 
    50                  55                  60                  


Pro Gly Met Phe Asn Phe Asp Thr Phe Trp Lys Asn Phe Lys Ser Lys 
65                  70                  75                  80  


Leu Gly Phe Ile Asn Trp Asp Ala Ile Asn Lys Asp Phe Lys Gln Asn 
                85                  90                  95      


Thr Pro Phe Leu Asn Trp Lys Ala Ile Ile Glu Gly Ala Asp Ala Ser 
            100                 105                 110         


Ser Leu Gln Lys Arg Ala Gly Arg Asp Asp Gln Pro Gly Ala Gly Trp 
        115                 120                 125             


Gln Glu Val Ala Ala Val Thr Ser Lys Asn Tyr Asn Tyr Asn Gln His 
    130                 135                 140                 


Ala Tyr Pro Thr Ala Tyr Gly Gly Lys Tyr Ser Val Lys Thr Pro Ala 
145                 150                 155                 160 


Lys Gly Gly Val Ser Pro Ser Ser Ser Ala Ser Arg Val Gln Pro Gly 
                165                 170                 175     


Leu Leu Gln Trp Val Lys Phe Trp 
            180                 


<210>  4324
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  4324

Met Leu Gly Ile Thr Ser Cys Ser Asp Gln Gln Ala Lys Glu Gly Glu 
1               5                   10                  15      


Gly Leu Glu Gly Ser Ser Thr Gly Ser Ser Ser Gly Asn His Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Asn Gly His Lys Pro Gly Cys Glu Lys Pro Gly Asn 
        35                  40                  45              


Glu Ala Arg Gly Ser Gly Glu Ser Gly Ile Gln Asn Ser Glu Thr Ser 
    50                  55                  60                  


Pro Gly Met Phe Asn Phe Asp Thr Phe Trp Lys Asn Phe Lys Ser Lys 
65                  70                  75                  80  


Leu Gly Phe Ile Asn Trp Asp Ala Ile Asn Lys Asp Gln Arg Ser Ser 
                85                  90                  95      


Arg Ile Pro 
            


<210>  4325
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  4325

Met Leu Gly Ile Thr Ser Cys Ser Asp Gln Gln Ala Lys Glu Gly Glu 
1               5                   10                  15      


Gly Leu Glu Gly Ser Ser Thr Gly Ser Ser Ser Gly Asn His Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Asn Gly His Lys Pro Gly Cys Glu Lys Pro Gly Asn 
        35                  40                  45              


Glu Ala Arg Gly Ser Gly Glu Ser Gly Ile Gln Asn Ser Glu Thr Ser 
    50                  55                  60                  


Pro Gly Met Phe Asn Phe Asp Thr Phe Trp Lys Asn Phe Lys Ser Lys 
65                  70                  75                  80  


Leu Gly Phe Ile Asn Trp Asp Ala Ile Asn Lys Asn Gln Val Pro Pro 
                85                  90                  95      


Pro Ser Thr Arg Ala Leu Leu Tyr Phe Ser Arg Leu Trp Glu Asp Phe 
            100                 105                 110         


Lys Gln Asn Thr Pro Phe Leu Asn Trp Lys Ala Ile Ile Glu Gly Ala 
        115                 120                 125             


Asp Ala Ser Ser Leu Gln Lys Arg Ala Gly Arg Asp Asp Gln Asn Tyr 
    130                 135                 140                 


Asn Tyr Asn Gln His Ala Tyr Pro Thr Ala Tyr Gly Gly Lys Tyr Ser 
145                 150                 155                 160 


Val Lys Thr Pro Ala Lys Gly Gly Val Ser Pro Ser Ser Ser Ala Ser 
                165                 170                 175     


Arg Val Gln Pro Gly Leu Leu Gln Trp Val Lys Phe Trp 
            180                 185                 


<210>  4326
<211>  203
<212>  PRT
<213>  Homo Sapiens

<400>  4326

Met Leu Gly Ile Thr Ser Cys Ser Asp Gln Gln Ala Lys Glu Gly Glu 
1               5                   10                  15      


Gly Leu Glu Gly Ser Ser Thr Gly Ser Ser Ser Gly Asn His Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Asn Gly His Lys Pro Gly Cys Glu Lys Pro Gly Asn 
        35                  40                  45              


Glu Ala Arg Gly Ser Gly Glu Ser Gly Ile Gln Asn Ser Glu Thr Ser 
    50                  55                  60                  


Pro Gly Met Phe Asn Phe Asp Thr Phe Trp Lys Asn Phe Lys Ser Lys 
65                  70                  75                  80  


Leu Gly Phe Ile Asn Trp Asp Ala Ile Asn Lys Asn Gln Val Pro Pro 
                85                  90                  95      


Pro Ser Thr Arg Ala Leu Leu Tyr Phe Ser Arg Leu Trp Glu Asp Phe 
            100                 105                 110         


Lys Gln Asn Thr Pro Phe Leu Asn Trp Lys Ala Ile Ile Glu Gly Ala 
        115                 120                 125             


Asp Ala Ser Ser Leu Gln Lys Arg Ala Gly Arg Asp Asp Gln Pro Gly 
    130                 135                 140                 


Ala Gly Trp Gln Glu Val Ala Ala Val Thr Ser Lys Asn Tyr Asn Tyr 
145                 150                 155                 160 


Asn Gln His Ala Tyr Pro Thr Ala Tyr Gly Gly Lys Tyr Ser Val Lys 
                165                 170                 175     


Thr Pro Ala Lys Gly Gly Val Ser Pro Ser Ser Ser Ala Ser Arg Val 
            180                 185                 190         


Gln Pro Gly Leu Leu Gln Trp Val Lys Phe Trp 
        195                 200             


<210>  4327
<211>  203
<212>  PRT
<213>  Homo Sapiens

<400>  4327

Met Leu Gly Ile Thr Ser Cys Ser Asp Gln Gln Ala Lys Glu Gly Glu 
1               5                   10                  15      


Gly Leu Glu Gly Ser Ser Thr Gly Ser Ser Ser Gly Asn His Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Asn Gly His Lys Pro Gly Cys Glu Lys Pro Gly Asn 
        35                  40                  45              


Glu Ala Arg Gly Ser Gly Glu Ser Gly Ile Gln Asn Ser Glu Thr Ser 
    50                  55                  60                  


Pro Gly Met Phe Asn Phe Asp Thr Phe Trp Lys Asn Phe Lys Ser Lys 
65                  70                  75                  80  


Leu Gly Phe Ile Asn Trp Asp Ala Ile Asn Lys Asn Gln Val Pro Pro 
                85                  90                  95      


Pro Ser Thr Arg Ala Leu Leu Tyr Phe Ser Arg Leu Trp Glu Asp Phe 
            100                 105                 110         


Lys Gln Asn Thr Pro Phe Leu Asn Trp Lys Ala Ile Ile Glu Gly Ala 
        115                 120                 125             


Asp Ala Ser Ser Leu Gln Lys Arg Ala Gly Arg Asp Asp Gln Pro Gly 
    130                 135                 140                 


Ala Gly Trp Gln Glu Val Ala Ala Val Thr Ser Lys Asn Tyr Asn Tyr 
145                 150                 155                 160 


Asn Gln His Ala Tyr Pro Thr Ala Tyr Gly Gly Lys Tyr Ser Val Lys 
                165                 170                 175     


Thr Pro Ala Lys Gly Gly Val Ser Pro Ser Ser Ser Ala Ser Arg Val 
            180                 185                 190         


Gln Pro Gly Leu Leu Gln Trp Val Lys Phe Trp 
        195                 200             


<210>  4328
<211>  82
<212>  PRT
<213>  Homo Sapiens

<400>  4328

Met Leu Gly Ile Thr Ser Cys Ser Asp Gln Gln Ala Lys Glu Gly Glu 
1               5                   10                  15      


Gly Leu Glu Gly Ser Ser Thr Gly Ser Ser Ser Gly Asn His Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Asn Gly His Lys Pro Gly Asn Ser Glu Thr Ser Pro 
        35                  40                  45              


Gly Met Phe Asn Phe Asp Thr Phe Trp Lys Asn Phe Lys Ser Lys Leu 
    50                  55                  60                  


Gly Phe Ile Asn Trp Asp Ala Ile Asn Lys Asp Gln Arg Ser Ser Arg 
65                  70                  75                  80  


Ile Pro 
        


<210>  4329
<211>  172
<212>  PRT
<213>  Homo Sapiens

<400>  4329

Met Leu Gly Ile Thr Ser Cys Ser Asp Gln Gln Ala Lys Glu Gly Glu 
1               5                   10                  15      


Gly Leu Glu Gly Ser Ser Thr Gly Ser Ser Ser Gly Asn His Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Asn Gly His Lys Pro Gly Asn Ser Glu Thr Ser Pro 
        35                  40                  45              


Gly Met Phe Asn Phe Asp Thr Phe Trp Lys Asn Phe Lys Ser Lys Leu 
    50                  55                  60                  


Gly Phe Ile Asn Trp Asp Ala Ile Asn Lys Asn Gln Val Pro Pro Pro 
65                  70                  75                  80  


Ser Thr Arg Ala Leu Leu Tyr Phe Ser Arg Leu Trp Glu Asp Phe Lys 
                85                  90                  95      


Gln Asn Thr Pro Phe Leu Asn Trp Lys Ala Ile Ile Glu Gly Ala Asp 
            100                 105                 110         


Ala Ser Ser Leu Gln Lys Arg Ala Gly Arg Asp Asp Gln Asn Tyr Asn 
        115                 120                 125             


Tyr Asn Gln His Ala Tyr Pro Thr Ala Tyr Gly Gly Lys Tyr Ser Val 
    130                 135                 140                 


Lys Thr Pro Ala Lys Gly Gly Val Ser Pro Ser Ser Ser Ala Ser Arg 
145                 150                 155                 160 


Val Gln Pro Gly Leu Leu Gln Trp Val Lys Phe Trp 
                165                 170         


<210>  4330
<211>  90
<212>  PRT
<213>  Homo Sapiens

<400>  4330

Met Asn Met Lys Pro Ala Thr Ala Ser Ala Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Ala Trp Thr Gln Gly Ser His Gly Trp Gly Ala Asp Ala Ser 
            20                  25                  30          


Ser Leu Gln Lys Arg Ala Gly Arg Asp Asp Gln Asn Tyr Asn Tyr Asn 
        35                  40                  45              


Gln His Ala Tyr Pro Thr Ala Tyr Gly Gly Lys Tyr Ser Val Lys Thr 
    50                  55                  60                  


Pro Ala Lys Gly Gly Val Ser Pro Ser Ser Ser Ala Ser Arg Val Gln 
65                  70                  75                  80  


Pro Gly Leu Leu Gln Trp Val Lys Phe Trp 
                85                  90  


<210>  4331
<211>  36
<212>  PRT
<213>  Homo Sapiens

<400>  4331

Ser Gly Asn His Gly Gly Ser Gly Gly Gly Asn Gly His Lys Pro Gly 
1               5                   10                  15      


Ile Ser Arg Leu Trp Leu Thr Lys Trp Val Leu Leu Ser Ser His Ile 
            20                  25                  30          


Ser Leu Val Pro 
        35      


<210>  4332
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  4332

Ser Ser Thr Gly Ser Ser Ser Gly Asn His Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Asn Gly His Lys Pro Gly Asn Ser Glu Thr Ser Pro Gly Met Phe Asn 
            20                  25                  30          


Phe Asp Thr Phe Trp Lys Asn Phe Lys Ser Lys Leu Gly Phe Ile Asn 
        35                  40                  45              


Trp Asp Ala Ile Asn Lys Asn Gln Val Pro Pro Pro Ser Thr Arg Ala 
    50                  55                  60                  


Leu Leu Tyr Phe Ser Arg Leu Trp Glu Asp Phe Lys Gln Asn Thr Pro 
65                  70                  75                  80  


Phe Leu Asn Trp Lys Ala Ile Ile Glu Gly Ala Asp Ala Ser Ser Leu 
                85                  90                  95      


Gln Lys Arg Ala Gly Arg Asp Asp Gln Asn Tyr Asn Tyr Asn Gln His 
            100                 105                 110         


Ala Tyr Pro Thr Ala Tyr Gly Gly Lys Tyr Ser Val Lys Thr Pro Ala 
        115                 120                 125             


Lys Gly Gly Val Ser Pro Ser Ser Ser Ala Ser Arg Val Gln Pro Gly 
    130                 135                 140                 


Leu Leu Gln Trp Val Lys Phe Trp 
145                 150         


<210>  4333
<211>  74
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4333

Xaa Ala Leu Leu Leu Leu Leu Leu Gly Leu Ala Trp Thr Gln Gly Ser 
1               5                   10                  15      


His Gly Trp Gly Ala Asp Ala Ser Ser Leu Gln Lys Arg Ala Gly Arg 
            20                  25                  30          


Asp Asp Gln Asn Tyr Asn Tyr Asn Gln His Ala Tyr Pro Thr Ala Tyr 
        35                  40                  45              


Gly Gly Lys Tyr Ser Val Lys Thr Pro Ala Lys Ala Ser Arg Val Gln 
    50                  55                  60                  


Pro Gly Leu Leu Gln Trp Val Lys Phe Trp 
65                  70                  


<210>  4334
<211>  201
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4334

Xaa Gly Gly Gly Asn Gly His Lys Pro Gly Cys Glu Lys Pro Gly Asn 
1               5                   10                  15      


Glu Ala Arg Gly Ser Gly Glu Ser Gly Ile Gln Gly Phe Arg Gly Gln 
            20                  25                  30          


Gly Val Ser Ser Asn Met Arg Glu Ile Ser Lys Glu Gly Asn Arg Leu 
        35                  40                  45              


Leu Gly Gly Ser Gly Asp Asn Tyr Arg Asn Ser Glu Thr Ser Pro Gly 
    50                  55                  60                  


Met Phe Asn Phe Asp Thr Phe Trp Lys Asn Phe Lys Ser Lys Leu Gly 
65                  70                  75                  80  


Phe Ile Asn Trp Asp Ala Ile Asn Lys Asn Gln Val Pro Pro Pro Ser 
                85                  90                  95      


Thr Arg Ala Leu Leu Tyr Phe Ser Arg Leu Trp Glu Asp Phe Lys Gln 
            100                 105                 110         


Asn Thr Pro Phe Leu Asn Trp Lys Ala Ile Ile Glu Gly Ala Asp Ala 
        115                 120                 125             


Ser Ser Leu Gln Lys Arg Ala Gly Arg Asp Asp Gln Pro Gly Ala Gly 
    130                 135                 140                 


Trp Gln Glu Val Ala Ala Val Thr Ser Lys Asn Tyr Asn Tyr Asn Gln 
145                 150                 155                 160 


His Ala Tyr Pro Thr Ala Tyr Gly Gly Lys Tyr Ser Val Lys Thr Pro 
                165                 170                 175     


Ala Lys Gly Gly Val Ser Pro Ser Ser Ser Ala Ser Arg Val Gln Pro 
            180                 185                 190         


Gly Leu Leu Gln Trp Val Lys Phe Trp 
        195                 200     


<210>  4335
<211>  109
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4335

Xaa Pro Ala Thr Ala Ser Ala Leu Leu Leu Leu Leu Leu Gly Leu Ala 
1               5                   10                  15      


Trp Thr Gln Gly Ser His Gly Trp Val Gly Thr Ala Gly Cys Thr Gly 
            20                  25                  30          


Cys Gly Arg Val Ile Thr Ala Glu Thr Cys Arg Gln Arg Arg Ser Glu 
        35                  40                  45              


Leu Gln Leu Gln Pro Ala Cys Val Ser His Cys Leu Trp Trp Glu Val 
    50                  55                  60                  


Leu Ser Gln Asp Pro Cys Lys Gly Gly Ser Leu Thr Phe Phe Leu Gly 
65                  70                  75                  80  


Phe Pro Gly Ala Thr Trp Pro Ala Ala Val Gly Glu Val Leu Val Gly 
                85                  90                  95      


Asn Phe Leu Gln Pro Pro Pro Arg Pro Arg Lys Ala Leu 
            100                 105                 


<210>  4336
<211>  96
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4336

Xaa Pro Pro Pro Ser Thr Arg Ala Leu Leu Tyr Phe Ser Arg Leu Trp 
1               5                   10                  15      


Glu Asp Phe Lys Gln Asn Thr Pro Phe Leu Asn Trp Lys Ala Ile Ile 
            20                  25                  30          


Glu Gly Ala Asp Ala Ser Ser Leu Gln Lys Arg Ala Gly Arg Asp Asp 
        35                  40                  45              


Gln Asn Tyr Asn Tyr Asn Gln His Ala Tyr Pro Thr Ala Tyr Gly Gly 
    50                  55                  60                  


Lys Tyr Ser Val Lys Thr Pro Ala Lys Gly Gly Val Ser Pro Ser Ser 
65                  70                  75                  80  


Ser Ala Ser Arg Val Gln Pro Gly Leu Leu Gln Trp Val Lys Phe Trp 
                85                  90                  95      


<210>  4337
<211>  497
<212>  PRT
<213>  Homo Sapiens

<400>  4337

Met Lys Ile Ser Ile Leu Leu Met Phe Leu Trp Gly Leu Ser Cys Ala 
1               5                   10                  15      


Leu Pro Val Thr Arg Tyr Gln Asn Asn Glu Ser Glu Asp Ser Glu Glu 
            20                  25                  30          


Trp Lys Gly His Leu Ala Gln Ala Pro Thr Pro Pro Leu Ala Asn Glu 
        35                  40                  45              


Asp Pro Ser Asp Ser Thr Gln Ser Glu Glu Gly Leu Gly Ser Asp Asp 
    50                  55                  60                  


His Gln Tyr Ile Tyr Arg Leu Ala Gly Gly Phe Ser Arg Ser Thr Gly 
65                  70                  75                  80  


Lys Gly Gly Asp Asp Lys Asp Asp Asp Glu Asp Asp Ser Gly Asp Asp 
                85                  90                  95      


Thr Phe Gly Asp Asp Asp Ser Gly Pro Gly Pro Lys Asp Arg Gln Glu 
            100                 105                 110         


Gly Gly Asn Ser Arg Leu Gly Ser Asp Glu Asp Ser Asp Asp Thr Ile 
        115                 120                 125             


Gln Ala Ser Glu Glu Ser Ala Pro Gln Gly Gln Asp Ser Ala Gln Asp 
    130                 135                 140                 


Thr Thr Ser Glu Ser Arg Glu Leu Asp Asn Glu Asp Arg Val Asp Ser 
145                 150                 155                 160 


Lys Pro Glu Gly Gly Asp Ser Thr Gln Glu Ser Glu Ser Glu Glu His 
                165                 170                 175     


Trp Val Gly Gly Gly Ser Asp Gly Glu Ser Ser His Gly Asp Gly Ser 
            180                 185                 190         


Glu Leu Asp Asp Glu Gly Met Gln Ser Asp Asp Pro Glu Ser Ile Arg 
        195                 200                 205             


Ser Glu Arg Gly Asn Ser Arg Met Asn Ser Ala Gly Met Lys Ser Lys 
    210                 215                 220                 


Glu Ser Gly Glu Asn Ser Glu Gln Ala Asn Thr Gln Asp Ser Gly Gly 
225                 230                 235                 240 


Ser Gln Leu Leu Glu His Pro Ser Arg Lys Ile Phe Arg Lys Ser Arg 
                245                 250                 255     


Ile Ser Glu Glu Asp Asp Arg Ser Glu Leu Asp Asp Asn Asn Thr Met 
            260                 265                 270         


Glu Glu Val Lys Ser Asp Ser Thr Glu Asn Ser Asn Ser Arg Asp Thr 
        275                 280                 285             


Gly Leu Ser Gln Pro Arg Arg Asp Ser Lys Gly Asp Ser Gln Glu Asp 
    290                 295                 300                 


Ser Lys Glu Asn Leu Ser Gln Glu Glu Ser Gln Asn Val Asp Gly Pro 
305                 310                 315                 320 


Ser Ser Glu Ser Ser Gln Glu Ala Asn Leu Ser Ser Gln Glu Asn Ser 
                325                 330                 335     


Ser Glu Ser Gln Glu Glu Val Val Ser Glu Ser Arg Gly Asp Asn Pro 
            340                 345                 350         


Asp Pro Thr Thr Ser Tyr Val Glu Asp Gln Glu Asp Ser Asp Ser Ser 
        355                 360                 365             


Glu Glu Asp Ser Ser His Thr Leu Ser His Ser Lys Ser Glu Ser Arg 
    370                 375                 380                 


Glu Glu Gln Ala Asp Ser Glu Ser Ser Glu Ser Leu Asn Phe Ser Glu 
385                 390                 395                 400 


Glu Ser Pro Glu Ser Pro Glu Asp Glu Asn Ser Ser Ser Gln Glu Gly 
                405                 410                 415     


Leu Gln Ser His Ser Ser Ser Ala Glu Ser Gln Ser Glu Glu Ser His 
            420                 425                 430         


Ser Glu Glu Asp Asp Ser Asp Ser Gln Asp Ser Ser Arg Ser Lys Glu 
        435                 440                 445             


Asp Ser Asn Ser Thr Glu Ser Lys Ser Ser Ser Glu Glu Asp Gly Gln 
    450                 455                 460                 


Leu Lys Asn Ile Glu Ile Glu Ser Arg Lys Leu Thr Val Asp Ala Tyr 
465                 470                 475                 480 


His Asn Lys Pro Ile Gly Asp Gln Asp Asp Asn Asp Cys Gln Asp Gly 
                485                 490                 495     


Tyr 
    


<210>  4338
<211>  513
<212>  PRT
<213>  Homo Sapiens

<400>  4338

Met Lys Ile Ser Ile Leu Leu Met Phe Leu Trp Gly Leu Ser Cys Ala 
1               5                   10                  15      


Leu Pro Val Thr Arg Tyr Gln Asn Asn Glu Ser Glu Asp Ser Glu Glu 
            20                  25                  30          


Trp Lys Gly His Leu Ala Gln Ala Pro Thr Pro Pro Leu Glu Ser Ser 
        35                  40                  45              


Glu Ser Ser Glu Gly Ser Lys Val Ser Ser Glu Glu Gln Ala Asn Glu 
    50                  55                  60                  


Asp Pro Ser Asp Ser Thr Gln Ser Glu Glu Gly Leu Gly Ser Asp Asp 
65                  70                  75                  80  


His Gln Tyr Ile Tyr Arg Leu Ala Gly Gly Phe Ser Arg Ser Thr Gly 
                85                  90                  95      


Lys Gly Gly Asp Asp Lys Asp Asp Asp Glu Asp Asp Ser Gly Asp Asp 
            100                 105                 110         


Thr Phe Gly Asp Asp Asp Ser Gly Pro Gly Pro Lys Asp Arg Gln Glu 
        115                 120                 125             


Gly Gly Asn Ser Arg Leu Gly Ser Asp Glu Asp Ser Asp Asp Thr Ile 
    130                 135                 140                 


Gln Ala Ser Glu Glu Ser Ala Pro Gln Gly Gln Asp Ser Ala Gln Asp 
145                 150                 155                 160 


Thr Thr Ser Glu Ser Arg Glu Leu Asp Asn Glu Asp Arg Val Asp Ser 
                165                 170                 175     


Lys Pro Glu Gly Gly Asp Ser Thr Gln Glu Ser Glu Ser Glu Glu His 
            180                 185                 190         


Trp Val Gly Gly Gly Ser Asp Gly Glu Ser Ser His Gly Asp Gly Ser 
        195                 200                 205             


Glu Leu Asp Asp Glu Gly Met Gln Ser Asp Asp Pro Glu Ser Ile Arg 
    210                 215                 220                 


Ser Glu Arg Gly Asn Ser Arg Met Asn Ser Ala Gly Met Lys Ser Lys 
225                 230                 235                 240 


Glu Ser Gly Glu Asn Ser Glu Gln Ala Asn Thr Gln Asp Ser Gly Gly 
                245                 250                 255     


Ser Gln Leu Leu Glu His Pro Ser Arg Lys Ile Phe Arg Lys Ser Arg 
            260                 265                 270         


Ile Ser Glu Glu Asp Asp Arg Ser Glu Leu Asp Asp Asn Asn Thr Met 
        275                 280                 285             


Glu Glu Val Lys Ser Asp Ser Thr Glu Asn Ser Asn Ser Arg Asp Thr 
    290                 295                 300                 


Gly Leu Ser Gln Pro Arg Arg Asp Ser Lys Gly Asp Ser Gln Glu Asp 
305                 310                 315                 320 


Ser Lys Glu Asn Leu Ser Gln Glu Glu Ser Gln Asn Val Asp Gly Pro 
                325                 330                 335     


Ser Ser Glu Ser Ser Gln Glu Ala Asn Leu Ser Ser Gln Glu Asn Ser 
            340                 345                 350         


Ser Glu Ser Gln Glu Glu Val Val Ser Glu Ser Arg Gly Asp Asn Pro 
        355                 360                 365             


Asp Pro Thr Thr Ser Tyr Val Glu Asp Gln Glu Asp Ser Asp Ser Ser 
    370                 375                 380                 


Glu Glu Asp Ser Ser His Thr Leu Ser His Ser Lys Ser Glu Ser Arg 
385                 390                 395                 400 


Glu Glu Gln Ala Asp Ser Glu Ser Ser Glu Ser Leu Asn Phe Ser Glu 
                405                 410                 415     


Glu Ser Pro Glu Ser Pro Glu Asp Glu Asn Ser Ser Ser Gln Glu Gly 
            420                 425                 430         


Leu Gln Ser His Ser Ser Ser Ala Glu Ser Gln Ser Glu Glu Ser His 
        435                 440                 445             


Ser Glu Glu Asp Asp Ser Asp Ser Gln Asp Ser Ser Arg Ser Lys Glu 
    450                 455                 460                 


Asp Ser Asn Ser Thr Glu Ser Lys Ser Ser Ser Glu Glu Asp Gly Gln 
465                 470                 475                 480 


Leu Lys Asn Ile Glu Ile Glu Ser Arg Lys Leu Thr Val Asp Ala Tyr 
                485                 490                 495     


His Asn Lys Pro Ile Gly Asp Gln Asp Asp Asn Asp Cys Gln Asp Gly 
            500                 505                 510         


Tyr 
    


<210>  4339
<211>  542
<212>  PRT
<213>  Homo Sapiens

<400>  4339

Met Glu Leu Arg Ser Glu Leu Pro Ser Val Pro Gly Ala Ala Thr Ala 
1               5                   10                  15      


Ala Ala Ala Thr Ala Thr Gly Pro Pro Val Ala Ser Val Ala Ser Val 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Ala Ser Leu Pro Val Ser Val Ala Gly 
        35                  40                  45              


Gly Leu Leu Arg Gly Pro Pro Leu Leu Leu Arg Ala Ala Glu Lys Tyr 
    50                  55                  60                  


Pro Arg Thr Pro Lys Cys Ala Arg Cys Arg Asn His Gly Val Val Ser 
65                  70                  75                  80  


Ala Leu Lys Gly His Lys Arg Tyr Cys Arg Trp Lys Asp Cys Leu Cys 
                85                  90                  95      


Ala Lys Cys Thr Leu Ile Ala Glu Arg Gln Arg Val Met Ala Ala Gln 
            100                 105                 110         


Val Ala Leu Arg Arg Gln Gln Ala Gln Glu Glu Asn Glu Ala Arg Glu 
        115                 120                 125             


Leu Gln Leu Leu Tyr Gly Thr Ala Glu Gly Leu Ala Leu Ala Ala Ala 
    130                 135                 140                 


Asn Gly Ile Ile Pro Pro Arg Pro Ala Tyr Glu Val Phe Gly Ser Val 
145                 150                 155                 160 


Cys Ala Ala Asp Gly Gly Gly Pro Gly Ala Gly Ala Pro Ala Gly Thr 
                165                 170                 175     


Gly Gly Gly Ala Ala Gly Ala Gly Gly Ser Glu Ala Lys Leu Gln Lys 
            180                 185                 190         


Phe Asp Leu Phe Pro Lys Thr Leu Leu Gln Ala Gly Arg Pro Gly Ser 
        195                 200                 205             


Pro Leu Pro Pro Pro Val Lys Pro Leu Ser Pro Asp Gly Ala Asp Ser 
    210                 215                 220                 


Gly Pro Gly Thr Ser Ser Pro Glu Val Arg Pro Gly Ser Gly Ser Glu 
225                 230                 235                 240 


Asn Gly Asp Gly Glu Ser Phe Ser Gly Ser Pro Leu Ala Arg Ala Ser 
                245                 250                 255     


Lys Glu Ala Gly Gly Ser Cys Pro Gly Ser Ala Gly Pro Gly Gly Gly 
            260                 265                 270         


Gly Glu Glu Asp Ser Pro Gly Ser Ala Ser Pro Leu Gly Ser Glu Ser 
        275                 280                 285             


Gly Ser Glu Ala Asp Lys Glu Glu Gly Glu Ala Ala Pro Ala Pro Gly 
    290                 295                 300                 


Leu Gly Gly Gly Ser Gly Pro Arg Gln Arg Thr Pro Leu Asp Ile Leu 
305                 310                 315                 320 


Thr Arg Val Phe Pro Gly His Arg Arg Gly Val Leu Glu Leu Val Leu 
                325                 330                 335     


Gln Gly Cys Gly Gly Asp Val Val Gln Ala Ile Glu Gln Val Leu Asn 
            340                 345                 350         


His His Arg Gly Gly Leu Ala Ala Gly Leu Gly Pro Ala Ala Pro Pro 
        355                 360                 365             


Asp Lys Ala Ala Val Gly Ala Ala Ala Ala Ala Asp Asp Ala Trp Pro 
    370                 375                 380                 


Ser Arg Val Asp Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Gly Pro 
385                 390                 395                 400 


Gly Leu Pro Ala Pro Leu Gln Ala Gly Pro Ala Ala Pro Pro His His 
                405                 410                 415     


Arg Pro Leu Leu Ala Gly Ala Met Ala Pro Gly Ala Leu Gly Ser Leu 
            420                 425                 430         


Ser Ser Arg Ser Ala Phe Ser Pro Leu Gln Pro Asn Ala Ser His Phe 
        435                 440                 445             


Gly Ala Asp Ala Gly Ala Tyr Pro Leu Gly Ala Pro Leu Gly Leu Ser 
    450                 455                 460                 


Pro Leu Arg Leu Ala Tyr Ser Ala Ala Ala Ala His Ser Arg Gly Leu 
465                 470                 475                 480 


Ala Phe Met Ala Pro Tyr Ser Thr Ala Gly Leu Val Pro Thr Leu Gly 
                485                 490                 495     


Phe Arg Pro Pro Met Asp Tyr Ala Phe Ser Asp Leu Met Arg Asp Arg 
            500                 505                 510         


Ser Ala Ala Ala Ala Ala Ala Val His Lys Glu Pro Thr Tyr Gly Gly 
        515                 520                 525             


Gly Leu Tyr Gly Pro Met Val Asn Gly Ala Pro Glu Lys Gln 
    530                 535                 540         


<210>  4340
<211>  542
<212>  PRT
<213>  Homo Sapiens

<400>  4340

Met Glu Leu Arg Ser Glu Leu Pro Ser Val Pro Gly Ala Ala Thr Ala 
1               5                   10                  15      


Ala Ala Ala Thr Ala Thr Gly Pro Pro Val Ala Ser Val Ala Ser Val 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Ala Ser Leu Pro Val Ser Val Ala Gly 
        35                  40                  45              


Gly Leu Leu Arg Gly Pro Pro Leu Leu Leu Arg Ala Ala Glu Lys Tyr 
    50                  55                  60                  


Pro Arg Thr Pro Lys Cys Ala Arg Cys Arg Asn His Gly Val Val Ser 
65                  70                  75                  80  


Ala Leu Lys Gly His Lys Arg Tyr Cys Arg Trp Lys Asp Cys Leu Cys 
                85                  90                  95      


Ala Lys Cys Thr Leu Ile Ala Glu Arg Gln Arg Val Met Ala Ala Gln 
            100                 105                 110         


Val Ala Leu Arg Arg Gln Gln Ala Gln Glu Glu Asn Glu Ala Arg Glu 
        115                 120                 125             


Leu Gln Leu Leu Tyr Gly Thr Ala Glu Gly Leu Ala Leu Ala Ala Ala 
    130                 135                 140                 


Asn Gly Ile Ile Pro Pro Arg Pro Ala Tyr Glu Val Phe Gly Ser Val 
145                 150                 155                 160 


Cys Ala Ala Asp Gly Gly Gly Pro Gly Ala Gly Ala Pro Ala Gly Thr 
                165                 170                 175     


Gly Gly Gly Ala Ala Gly Ala Gly Gly Ser Glu Ala Lys Leu Gln Lys 
            180                 185                 190         


Phe Asp Leu Phe Pro Lys Thr Leu Leu Gln Ala Gly Arg Pro Gly Ser 
        195                 200                 205             


Pro Leu Pro Pro Pro Val Lys Pro Leu Ser Pro Asp Gly Ala Asp Ser 
    210                 215                 220                 


Gly Pro Gly Thr Ser Ser Pro Glu Val Arg Pro Gly Ser Gly Ser Glu 
225                 230                 235                 240 


Asn Gly Asp Gly Glu Ser Phe Ser Gly Ser Pro Leu Ala Arg Ala Ser 
                245                 250                 255     


Lys Glu Ala Gly Gly Ser Cys Pro Gly Ser Ala Gly Pro Gly Gly Gly 
            260                 265                 270         


Gly Glu Glu Asp Ser Pro Gly Ser Ala Ser Pro Leu Gly Ser Glu Ser 
        275                 280                 285             


Gly Ser Glu Ala Asp Lys Glu Glu Gly Glu Ala Ala Pro Ala Pro Gly 
    290                 295                 300                 


Leu Gly Gly Gly Ser Gly Pro Arg Gln Arg Thr Pro Leu Asp Ile Leu 
305                 310                 315                 320 


Thr Arg Val Phe Pro Gly His Arg Arg Gly Val Leu Glu Leu Val Leu 
                325                 330                 335     


Gln Gly Cys Gly Gly Asp Val Val Gln Ala Ile Glu Gln Val Leu Asn 
            340                 345                 350         


His His Arg Gly Gly Leu Ala Ala Gly Leu Gly Pro Ala Ala Pro Pro 
        355                 360                 365             


Asp Lys Ala Ala Val Gly Ala Ala Ala Ala Ala Asp Asp Ala Trp Pro 
    370                 375                 380                 


Ser Arg Val Asp Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Gly Pro 
385                 390                 395                 400 


Gly Leu Pro Ala Pro Leu Gln Ala Gly Pro Ala Ala Pro Pro His His 
                405                 410                 415     


Arg Pro Leu Leu Ala Gly Ala Met Ala Pro Gly Ala Leu Gly Ser Leu 
            420                 425                 430         


Ser Ser Arg Ser Ala Phe Ser Pro Leu Gln Pro Asn Ala Ser His Phe 
        435                 440                 445             


Gly Ala Asp Ala Gly Ala Tyr Pro Leu Gly Ala Pro Leu Gly Leu Ser 
    450                 455                 460                 


Pro Leu Arg Leu Ala Tyr Ser Ala Ala Ala Ala His Ser Arg Gly Leu 
465                 470                 475                 480 


Ala Phe Met Ala Pro Tyr Ser Thr Ala Gly Leu Val Pro Thr Leu Gly 
                485                 490                 495     


Phe Arg Pro Pro Met Asp Tyr Ala Phe Ser Asp Leu Met Arg Asp Arg 
            500                 505                 510         


Ser Ala Ala Ala Ala Ala Ala Val His Lys Glu Pro Thr Tyr Gly Gly 
        515                 520                 525             


Gly Leu Tyr Gly Pro Met Val Asn Gly Ala Pro Glu Lys Gln 
    530                 535                 540         


<210>  4341
<211>  855
<212>  PRT
<213>  Homo Sapiens

<400>  4341

Met Ala Ala Leu Gly Val Ala Glu Ala Val Ala Ala Pro His Pro Ala 
1               5                   10                  15      


Glu Gly Ala Glu Thr Ala Glu Ala Val Glu Leu Ser Arg Ala Leu Ser 
            20                  25                  30          


Arg Leu Leu Pro Gly Leu Glu Ala Asp Ser Lys Pro Gly Arg Arg Arg 
        35                  40                  45              


Ala Leu Glu Ala Leu Arg Arg Ala Leu Glu Glu Pro Gly Pro Ala Ala 
    50                  55                  60                  


Asp Pro Thr Ala Phe Gln Gly Pro Trp Ala Arg Leu Leu Leu Pro Arg 
65                  70                  75                  80  


Leu Leu Arg Cys Leu Ser Asp Pro Ala Glu Gly Cys Arg Ala Leu Ala 
                85                  90                  95      


Val His Leu Leu Asp Leu Gly Leu Arg Arg Ala Ala Arg Pro Arg Asp 
            100                 105                 110         


Ala Leu Pro Arg Leu Leu Pro Ala Leu Ala Ala Arg Leu Ala Gly Pro 
        115                 120                 125             


Val Pro Ala Arg Arg Pro Pro Glu Ala Cys Glu Glu Leu Arg Leu Ala 
    130                 135                 140                 


Leu Val Gln Leu Leu Gly Leu Ala Val Asp Leu Cys Gly Ala Ala Leu 
145                 150                 155                 160 


Ala Pro His Leu Asp Asp Ala Leu Arg Ala Leu Arg Cys Ser Leu Leu 
                165                 170                 175     


Asp Pro Phe Ala Ala Val Arg Arg Glu Ser Cys Ser Cys Ala Ala Ala 
            180                 185                 190         


Leu Ala Gln Ala Thr Pro Asp His Phe His Met Gln Ser Glu Ser Leu 
        195                 200                 205             


Ile Gly Pro Leu Met Gln Thr Ile Ser His Gln His Trp Lys Val Arg 
    210                 215                 220                 


Val Ala Ala Ile Glu Ala Thr Gly Ala Val Ile His Phe Gly Asn Gly 
225                 230                 235                 240 


Lys Ser Val Asp Asp Val Leu Ser His Phe Ala Gln Arg Leu Phe Asp 
                245                 250                 255     


Asp Val Pro Gln Val Arg Arg Ala Val Ala Ser Val Val Gly Gly Trp 
            260                 265                 270         


Leu Leu Cys Leu Arg Asp Arg Tyr Ser Phe Phe His Lys Leu Ile Pro 
        275                 280                 285             


Leu Leu Leu Ser Ser Leu Asn Asp Glu Val Pro Glu Val Arg Gln Leu 
    290                 295                 300                 


Ala Ala Ser Leu Trp Glu Asp Val Gly Leu Gln Trp Gln Lys Glu Asn 
305                 310                 315                 320 


Glu Glu Asp Leu Lys Asp Lys Leu Asp Phe Ala Pro Pro Thr Pro Pro 
                325                 330                 335     


His Tyr Pro Pro His Glu Arg Arg Pro Val Leu Gly Cys Arg Glu Leu 
            340                 345                 350         


Val Phe Arg Asn Leu Ser Lys Ile Leu Pro Ala Leu Cys His Asp Ile 
        355                 360                 365             


Thr Asp Trp Val Val Gly Thr Arg Val Lys Ser Ala Gln Leu Leu Pro 
    370                 375                 380                 


Val Leu Leu Leu His Ala Glu Asp His Ala Thr Gln His Leu Glu Val 
385                 390                 395                 400 


Val Leu Arg Thr Leu Phe Gln Ala Cys Thr Asp Glu Glu Ala Ala Val 
                405                 410                 415     


Val Gln Ser Cys Thr Arg Ser Ala Glu Leu Val Gly Thr Phe Val Ser 
            420                 425                 430         


Pro Glu Val Phe Leu Lys Leu Ile Leu Ser Thr Leu Lys Lys Thr Pro 
        435                 440                 445             


Ser Ala Ser Gly Leu Leu Val Leu Ala Ser Ala Met Arg Gly Cys Pro 
    450                 455                 460                 


Arg Glu Ala Leu Gln Pro His Leu Ala Ala Ile Ala Thr Glu Leu Ala 
465                 470                 475                 480 


Gln Ala His Ile Cys Gln Ala Ser Glu Asn Asp Leu Tyr Leu Glu Arg 
                485                 490                 495     


Leu Leu Leu Cys Val Gln Ala Leu Val Ser Val Cys His Glu Asp Cys 
            500                 505                 510         


Gly Val Ala Ser Leu Gln Leu Leu Asp Val Leu Leu Thr Ile Val Ala 
        515                 520                 525             


Leu Ala Gly Ala Thr Gly Leu Arg Asp Lys Ala Gln Glu Thr Met Asp 
    530                 535                 540                 


Ser Leu Ala Met Val Glu Gly Val Ser Ser Cys Gln Asp Leu Tyr Arg 
545                 550                 555                 560 


Lys His Ile Gly Pro Leu Leu Glu Arg Val Thr Ala Ser His Leu Asp 
                565                 570                 575     


Trp Thr Ala His Ser Pro Glu Leu Leu Gln Phe Ser Val Ile Val Ala 
            580                 585                 590         


Gln Ser Gly Pro Ala Leu Gly Glu Ala Leu Pro His Val Val Pro Thr 
        595                 600                 605             


Leu Arg Ala Cys Leu Gln Pro Ser Gln Asp Pro Gln Met Arg Leu Lys 
    610                 615                 620                 


Leu Phe Ser Ile Leu Ser Thr Val Leu Leu Arg Ala Thr Asp Thr Ile 
625                 630                 635                 640 


Asn Ser Gln Gly Gln Phe Pro Ser Tyr Leu Glu Thr Val Thr Lys Asp 
                645                 650                 655     


Ile Leu Ala Pro Asn Leu Gln Trp His Ala Gly Arg Thr Ala Ala Ala 
            660                 665                 670         


Ile Arg Thr Ala Ala Val Ser Cys Leu Trp Ala Leu Thr Ser Ser Glu 
        675                 680                 685             


Val Leu Ser Ala Glu Gln Ile Arg Asp Val Gln Glu Thr Leu Met Pro 
    690                 695                 700                 


Gln Val Leu Thr Thr Leu Glu Glu Asp Ser Lys Met Thr Arg Leu Ile 
705                 710                 715                 720 


Ser Cys Arg Ile Ile Asn Thr Phe Leu Lys Thr Ser Gly Gly Met Thr 
                725                 730                 735     


Asp Pro Glu Lys Leu Ile Arg Ile Tyr Pro Glu Leu Leu Lys Arg Leu 
            740                 745                 750         


Asp Asp Val Ser Asn Asp Val Arg Met Ala Ala Ala Ser Thr Leu Val 
        755                 760                 765             


Thr Trp Leu Gln Cys Val Lys Gly Ala Asn Ala Lys Ser Tyr Tyr Gln 
    770                 775                 780                 


Ser Ser Val Gln Tyr Leu Tyr Arg Glu Leu Leu Val His Leu Asp Asp 
785                 790                 795                 800 


Pro Glu Arg Ala Ile Gln Asp Ala Ile Leu Glu Val Leu Lys Glu Gly 
                805                 810                 815     


Ser Gly Leu Phe Pro Asp Leu Leu Val Arg Glu Thr Glu Ala Val Ile 
            820                 825                 830         


His Lys His Arg Ser Ala Thr Tyr Cys Glu Gln Leu Leu Gln His Val 
        835                 840                 845             


Gln Ala Val Pro Ala Thr Gln 
    850                 855 


<210>  4342
<211>  280
<212>  PRT
<213>  Homo Sapiens

<400>  4342

Met Thr Gly Gly Ala Arg Glu Lys Ala His Ile Ala Arg Ser Pro Ala 
1               5                   10                  15      


Thr Ala Gln Gly Pro Ala Leu Gly Glu Ala Leu Pro His Val Val Pro 
            20                  25                  30          


Thr Leu Arg Ala Cys Leu Gln Pro Ser Gln Asp Pro Gln Met Arg Leu 
        35                  40                  45              


Lys Leu Phe Ser Ile Leu Ser Thr Val Leu Leu Arg Ala Thr Asp Thr 
    50                  55                  60                  


Ile Asn Ser Gln Gly Gln Phe Pro Ser Tyr Leu Glu Thr Val Thr Lys 
65                  70                  75                  80  


Asp Ile Leu Ala Pro Asn Leu Gln Trp His Ala Gly Arg Thr Ala Ala 
                85                  90                  95      


Ala Ile Arg Thr Ala Ala Val Ser Cys Leu Trp Ala Leu Thr Ser Ser 
            100                 105                 110         


Glu Val Leu Ser Ala Glu Gln Ile Arg Asp Val Gln Glu Thr Leu Met 
        115                 120                 125             


Pro Gln Val Leu Thr Thr Leu Glu Glu Asp Ser Lys Met Thr Arg Leu 
    130                 135                 140                 


Ile Ser Cys Arg Ile Ile Asn Thr Phe Leu Lys Thr Ser Gly Gly Met 
145                 150                 155                 160 


Thr Asp Pro Glu Lys Leu Ile Arg Ile Tyr Pro Glu Leu Leu Lys Arg 
                165                 170                 175     


Leu Asp Asp Val Ser Asn Asp Val Arg Met Ala Ala Ala Ser Thr Leu 
            180                 185                 190         


Val Thr Trp Leu Gln Cys Val Lys Gly Ala Asn Ala Lys Ser Tyr Tyr 
        195                 200                 205             


Gln Ser Ser Val Gln Tyr Leu Tyr Arg Glu Leu Leu Val His Leu Asp 
    210                 215                 220                 


Asp Pro Glu Arg Ala Ile Gln Asp Ala Ile Leu Glu Val Leu Lys Glu 
225                 230                 235                 240 


Gly Ser Gly Leu Phe Pro Asp Leu Leu Val Arg Glu Thr Glu Ala Val 
                245                 250                 255     


Ile His Lys His Arg Ser Ala Thr Tyr Cys Glu Gln Leu Leu Gln His 
            260                 265                 270         


Val Gln Ala Val Pro Ala Thr Gln 
        275                 280 


<210>  4343
<211>  196
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4343

Xaa Leu Cys Ala Arg Cys Ala Ala Pro Cys Ser Thr Pro Ser Pro Pro 
1               5                   10                  15      


Cys Ala Ala Arg Ala Ala Ala Ala Pro Pro Pro Trp Arg Arg Pro Arg 
            20                  25                  30          


Pro Val Arg Arg Ala Val Ala Ser Val Val Gly Gly Trp Leu Leu Cys 
        35                  40                  45              


Leu Arg Asp Arg Tyr Ser Phe Phe His Lys Leu Ile Pro Leu Leu Leu 
    50                  55                  60                  


Ser Ser Leu Asn Asp Glu Val Pro Glu Val Arg Gln Leu Ala Ala Ser 
65                  70                  75                  80  


Leu Trp Glu Asp Val Gly Leu Gln Trp Gln Lys Glu Asn Glu Glu Asp 
                85                  90                  95      


Leu Lys Asp Lys Leu Asp Phe Ala Pro Pro Thr Pro Pro His Tyr Pro 
            100                 105                 110         


Pro His Glu Arg Arg Pro Val Leu Gly Cys Arg Glu Leu Val Phe Arg 
        115                 120                 125             


Asn Leu Ser Lys Ile Leu Pro Ala Leu Cys His Asp Ile Thr Asp Trp 
    130                 135                 140                 


Val Val Gly Thr Arg Val Lys Ser Ala Gln Leu Leu Pro Val Leu Leu 
145                 150                 155                 160 


Leu His Ala Glu Asp His Ala Thr Gln His Leu Glu Val Val Leu Arg 
                165                 170                 175     


Thr Leu Phe Gln Ala Cys Thr Asp Glu Glu Ala Ala Val Val Gln Ser 
            180                 185                 190         


Cys Thr Arg Ser 
        195     


<210>  4344
<211>  657
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4344

Xaa Ser Pro Pro Cys Ala Ala Arg Ala Ala Ala Ala Pro Pro Pro Trp 
1               5                   10                  15      


Arg Arg Pro Arg Pro His Trp Lys Val Arg Val Ala Ala Ile Glu Ala 
            20                  25                  30          


Thr Gly Ala Val Ile His Phe Gly Asn Gly Lys Ser Val Asp Asp Val 
        35                  40                  45              


Leu Ser His Phe Ala Gln Arg Leu Phe Asp Asp Val Pro Gln Val Arg 
    50                  55                  60                  


Arg Ala Val Ala Ser Val Val Gly Gly Trp Leu Leu Cys Leu Arg Asp 
65                  70                  75                  80  


Arg Tyr Ser Phe Phe His Lys Leu Ile Pro Leu Leu Leu Ser Ser Leu 
                85                  90                  95      


Asn Asp Glu Val Pro Glu Val Arg Gln Leu Ala Ala Ser Leu Trp Glu 
            100                 105                 110         


Asp Val Gly Leu Gln Trp Gln Lys Glu Asn Glu Glu Asp Leu Lys Asp 
        115                 120                 125             


Lys Leu Asp Phe Ala Pro Pro Thr Pro Pro His Tyr Pro Pro His Glu 
    130                 135                 140                 


Arg Arg Pro Val Leu Gly Cys Arg Glu Leu Val Phe Arg Asn Leu Ser 
145                 150                 155                 160 


Lys Ile Leu Pro Ala Leu Cys His Asp Ile Thr Asp Trp Val Val Gly 
                165                 170                 175     


Thr Arg Val Lys Ser Ala Gln Leu Leu Pro Val Leu Leu Leu His Ala 
            180                 185                 190         


Glu Asp His Ala Thr Gln His Leu Glu Val Val Leu Arg Thr Leu Phe 
        195                 200                 205             


Gln Ala Cys Thr Asp Glu Glu Ala Ala Val Val Gln Ser Cys Thr Arg 
    210                 215                 220                 


Ser Ala Glu Leu Val Gly Thr Phe Val Ser Pro Glu Val Phe Leu Lys 
225                 230                 235                 240 


Leu Ile Leu Ser Thr Leu Lys Lys Thr Pro Ser Ala Ser Gly Leu Leu 
                245                 250                 255     


Val Leu Ala Ser Ala Met Arg Gly Cys Pro Arg Glu Ala Leu Gln Pro 
            260                 265                 270         


His Leu Ala Ala Ile Ala Thr Glu Leu Ala Gln Ala His Ile Cys Gln 
        275                 280                 285             


Ala Ser Glu Asn Asp Leu Tyr Leu Glu Arg Leu Leu Leu Cys Val Gln 
    290                 295                 300                 


Ala Leu Val Ser Val Cys His Glu Asp Cys Gly Val Ala Ser Leu Gln 
305                 310                 315                 320 


Leu Leu Asp Val Leu Leu Thr Ile Val Ala Leu Ala Gly Ala Thr Gly 
                325                 330                 335     


Leu Arg Asp Lys Ala Gln Glu Thr Met Asp Ser Leu Ala Met Val Glu 
            340                 345                 350         


Gly Val Ser Ser Cys Gln Asp Leu Tyr Arg Lys His Ile Gly Pro Leu 
        355                 360                 365             


Leu Glu Arg Val Thr Ala Ser His Leu Asp Trp Thr Ala His Ser Pro 
    370                 375                 380                 


Glu Leu Leu Gln Phe Ser Val Ile Val Ala Gln Ser Gly Pro Ala Leu 
385                 390                 395                 400 


Gly Glu Ala Leu Pro His Val Val Pro Thr Leu Arg Ala Cys Leu Gln 
                405                 410                 415     


Pro Ser Gln Asp Pro Gln Met Arg Leu Lys Leu Phe Ser Ile Leu Ser 
            420                 425                 430         


Thr Val Leu Leu Arg Ala Thr Asp Thr Ile Asn Ser Gln Gly Gln Phe 
        435                 440                 445             


Pro Ser Tyr Leu Glu Thr Val Thr Lys Asp Ile Leu Ala Pro Asn Leu 
    450                 455                 460                 


Gln Trp His Ala Gly Arg Thr Ala Ala Ala Ile Arg Thr Ala Ala Val 
465                 470                 475                 480 


Ser Cys Leu Trp Ala Leu Thr Ser Ser Glu Val Leu Ser Ala Glu Gln 
                485                 490                 495     


Ile Arg Asp Val Gln Glu Thr Leu Met Pro Gln Val Leu Thr Thr Leu 
            500                 505                 510         


Glu Glu Asp Ser Lys Met Thr Arg Leu Ile Ser Cys Arg Ile Ile Asn 
        515                 520                 525             


Thr Phe Leu Lys Thr Ser Gly Gly Met Thr Asp Pro Glu Lys Leu Ile 
    530                 535                 540                 


Arg Ile Tyr Pro Glu Leu Leu Lys Arg Leu Asp Asp Val Ser Asn Asp 
545                 550                 555                 560 


Val Arg Met Ala Ala Ala Ser Thr Leu Val Thr Trp Leu Gln Cys Val 
                565                 570                 575     


Lys Gly Ala Asn Ala Lys Ser Tyr Tyr Gln Ser Ser Val Gln Tyr Leu 
            580                 585                 590         


Tyr Arg Glu Leu Leu Val His Leu Asp Asp Pro Glu Arg Ala Ile Gln 
        595                 600                 605             


Asp Ala Ile Leu Glu Val Leu Lys Glu Gly Ser Gly Leu Phe Pro Asp 
    610                 615                 620                 


Leu Leu Val Arg Glu Thr Glu Ala Val Ile His Lys His Arg Ser Ala 
625                 630                 635                 640 


Thr Tyr Cys Glu Gln Leu Leu Gln His Val Gln Ala Val Pro Ala Thr 
                645                 650                 655     


Gln 
    


<210>  4345
<211>  68
<212>  PRT
<213>  Homo Sapiens

<400>  4345

Ala Glu Gly Glu Gly Leu Val Leu Pro Lys Lys Ile Arg Val Arg Ser 
1               5                   10                  15      


Ala Val Glu Gln Trp Leu Val Asn Val Glu Lys Ser Met Phe Asp Val 
            20                  25                  30          


Leu Lys Lys Phe Leu Ser Gln Gly Ile Glu Asp Trp Asn Cys Gln Met 
        35                  40                  45              


Phe Ser Gln Trp Val Leu Ser His Pro Gly Gln Val Val Leu Thr Val 
    50                  55                  60                  


Thr Phe Ala Ile 
65              


<210>  4346
<211>  130
<212>  PRT
<213>  Homo Sapiens

<400>  4346

Asp Tyr Leu Glu Val Lys Arg Leu Ile Phe Pro Arg Phe Tyr Phe Leu 
1               5                   10                  15      


Ser Asn Ala Glu Leu Leu Asp Ile Leu Ala Asp Ser Arg Asn Pro Glu 
            20                  25                  30          


Ser Val Gln Pro His Leu Val Lys Cys Phe Glu Asn Ile Lys Gln Leu 
        35                  40                  45              


Leu Ile Trp Lys Gln Asp Ile Gly Pro Pro Ala Val Lys Met Leu Ile 
    50                  55                  60                  


Ser Ala Glu Gly Glu Gly Leu Val Leu Pro Lys Tyr Asp Lys Cys Tyr 
65                  70                  75                  80  


Lys Leu Phe Arg Phe Cys Thr Thr Ser Leu Phe Lys Ile Ser Ala Leu 
                85                  90                  95      


Lys Phe Leu Ile Tyr Tyr Lys Ser Ala Leu Ser Lys Leu Phe Leu Gln 
            100                 105                 110         


Arg Leu Tyr Pro Tyr Val Asn Ile Leu Leu Pro Phe His Ile Pro Tyr 
        115                 120                 125             


Asn Thr 
    130 


<210>  4347
<211>  430
<212>  PRT
<213>  Homo Sapiens

<400>  4347

Met Glu Thr Phe Ile Pro Ile Asp Leu Thr Thr Glu Asn Gln Glu Met 
1               5                   10                  15      


Asp Lys Glu Glu Thr Lys Thr Lys Pro Arg Leu Leu Arg Tyr Glu Glu 
            20                  25                  30          


Lys Lys Tyr Glu Asp Val Lys Pro Leu Glu Thr Gln Pro Ala Glu Ile 
        35                  40                  45              


Ala Glu Lys Glu Thr Leu Glu Tyr Lys Thr Val Arg Thr Phe Ser Glu 
    50                  55                  60                  


Ser Leu Lys Ser Glu Lys Thr Glu Asp Tyr Leu Arg Glu Ser Ile Ile 
65                  70                  75                  80  


Gln Gln His Met Val Ser Pro Glu Pro Ala Ser Leu Lys Glu Lys Gly 
                85                  90                  95      


Lys Ser Arg Arg Lys Lys Asp Gln Thr His Ala Cys Pro Asn Val Arg 
            100                 105                 110         


Lys Ala Arg Pro Val Ser Tyr Asp Arg Thr Glu Pro Lys Asp Asp Asp 
        115                 120                 125             


Val Ile Arg Asn Ile Ile Arg Leu Arg Glu Lys Leu Gly Trp Gln Thr 
    130                 135                 140                 


Ile Leu Pro Gln His Ser Leu Lys Tyr Gly Ser Ser Lys Ile Ala Ile 
145                 150                 155                 160 


Gln Lys Ile Thr Leu Lys Lys Pro Leu Glu Asp Asp Gly Glu Phe Val 
                165                 170                 175     


Tyr Cys Leu Pro Arg Lys Ser Pro Lys Ser Leu Tyr Asn Pro Tyr Asp 
            180                 185                 190         


Leu Gln Val Ile Asn Ile Val Gly Ser Val Lys Glu Val Glu Leu Ile 
        195                 200                 205             


Pro Thr Leu Glu Trp Leu Ser Glu Arg Arg His Tyr Tyr Leu Leu Arg 
    210                 215                 220                 


Gln Phe Lys Ile Phe Ser Asp Phe Arg Met Asn Lys Ala Phe Val Thr 
225                 230                 235                 240 


Trp Lys Leu Asn Val Lys Arg Ile Lys Thr Glu Lys Ser Arg Ser Phe 
                245                 250                 255     


Leu Tyr His His Leu Phe Leu Ala Asp Asp Leu Phe Gln Thr Cys Leu 
            260                 265                 270         


Val Tyr Ile Arg Gly Leu Cys Glu Asp Ala Ile Asn Leu Lys Asn Tyr 
        275                 280                 285             


Asn Asp His Glu Asn Asn Leu Ser Ala Ile Cys Leu Val Lys Leu Asp 
    290                 295                 300                 


Ser Ser Arg Thr Tyr Ser Leu Asp Glu Phe Cys Glu Glu Gln Leu Gln 
305                 310                 315                 320 


Gln Ala Thr Gln Ala Leu Lys Gln Leu Glu Asp Ile Arg Asn Lys Ala 
                325                 330                 335     


Ile Ser Glu Met Lys Ser Thr Phe Leu Lys Val Ala Glu Lys Asn Glu 
            340                 345                 350         


Ile Lys Glu Tyr Phe Glu Ser Lys Leu Ser Glu Asp Asp Thr Thr His 
        355                 360                 365             


Phe Lys Leu Pro Lys Tyr Arg Arg Leu Leu Glu Thr Phe Phe Lys Phe 
    370                 375                 380                 


Val Met Leu Val Asp Tyr Ile Phe Gln Glu Leu Ile Arg Gln Leu Met 
385                 390                 395                 400 


Asn Thr Ala Val Thr Leu Leu Leu Glu Leu Phe Asn Gly Ser Ala Gly 
                405                 410                 415     


Met Pro Phe Ser Val Glu Lys Lys Asn Glu Asn Leu Ile Arg 
            420                 425                 430 


<210>  4348
<211>  228
<212>  PRT
<213>  Homo Sapiens

<400>  4348

Met Glu Thr Phe Ile Pro Ile Asp Leu Thr Thr Glu Asn Gln Glu Met 
1               5                   10                  15      


Asp Lys Glu Glu Thr Lys Thr Lys Pro Arg Leu Leu Arg Tyr Glu Glu 
            20                  25                  30          


Lys Lys Tyr Glu Asp Val Lys Pro Leu Glu Thr Gln Pro Ala Glu Ile 
        35                  40                  45              


Ala Glu Lys Glu Thr Leu Glu Tyr Lys Thr Val Arg Thr Phe Ser Glu 
    50                  55                  60                  


Ser Leu Lys Ser Glu Lys Thr Glu Asp Tyr Leu Arg Glu Ser Ile Ile 
65                  70                  75                  80  


Gln Gln His Met Val Ser Pro Glu Pro Ala Ser Leu Lys Glu Lys Gly 
                85                  90                  95      


Lys Ser Arg Arg Lys Lys Asp Gln Thr His Ala Cys Pro Asn Val Arg 
            100                 105                 110         


Lys Ala Arg Pro Val Ser Tyr Asp Arg Thr Glu Pro Lys Asp Asp Asp 
        115                 120                 125             


Val Ile Arg Asn Ile Ile Arg Leu Arg Glu Lys Leu Gly Trp Gln Thr 
    130                 135                 140                 


Ile Leu Pro Gln His Ser Leu Lys Tyr Gly Ser Ser Lys Ile Ala Ile 
145                 150                 155                 160 


Gln Lys Ile Thr Leu Lys Lys Pro Leu Glu Asp Asp Gly Glu Phe Val 
                165                 170                 175     


Tyr Cys Leu Pro Arg Lys Ser Pro Lys Ser Leu Tyr Asn Pro Tyr Asp 
            180                 185                 190         


Leu Gln Val Val Ser Ala His Thr Ala Lys His Cys Lys Glu Phe Trp 
        195                 200                 205             


Val Ile Thr Ala Ser Phe Ile Ser Lys Arg Tyr Leu Val Ile Cys Gly 
    210                 215                 220                 


Ala Val Tyr Ile 
225             


<210>  4349
<211>  228
<212>  PRT
<213>  Homo Sapiens

<400>  4349

Met Glu Thr Phe Ile Pro Ile Asp Leu Thr Thr Glu Asn Gln Glu Met 
1               5                   10                  15      


Asp Lys Glu Glu Thr Lys Thr Lys Pro Arg Leu Leu Arg Tyr Glu Glu 
            20                  25                  30          


Lys Lys Tyr Glu Asp Val Lys Pro Leu Glu Thr Gln Pro Ala Glu Ile 
        35                  40                  45              


Ala Glu Lys Glu Thr Leu Glu Tyr Lys Thr Val Arg Thr Phe Ser Glu 
    50                  55                  60                  


Ser Leu Lys Ser Glu Lys Thr Glu Asp Tyr Leu Arg Glu Ser Ile Ile 
65                  70                  75                  80  


Gln Gln His Met Val Ser Pro Glu Pro Ala Ser Leu Lys Glu Lys Gly 
                85                  90                  95      


Lys Ser Arg Arg Lys Lys Asp Gln Thr His Ala Cys Pro Asn Val Arg 
            100                 105                 110         


Lys Ala Arg Pro Val Ser Tyr Asp Arg Thr Glu Pro Lys Asp Asp Asp 
        115                 120                 125             


Val Ile Arg Asn Ile Ile Arg Leu Arg Glu Lys Leu Gly Trp Gln Thr 
    130                 135                 140                 


Ile Leu Pro Gln His Ser Leu Lys Tyr Gly Ser Ser Lys Ile Ala Ile 
145                 150                 155                 160 


Gln Lys Ile Thr Leu Lys Lys Pro Leu Glu Asp Asp Gly Glu Phe Val 
                165                 170                 175     


Tyr Cys Leu Pro Arg Lys Ser Pro Lys Ser Leu Tyr Asn Pro Tyr Asp 
            180                 185                 190         


Leu Gln Val Val Ser Ala His Thr Ala Lys His Cys Lys Glu Phe Trp 
        195                 200                 205             


Val Ile Thr Ala Ser Phe Ile Ser Lys Arg Tyr Leu Val Ile Cys Gly 
    210                 215                 220                 


Ala Val Tyr Ile 
225             


<210>  4350
<211>  4515
<212>  PRT
<213>  Homo Sapiens

<400>  4350

Met Glu Thr Phe Ile Pro Ile Asp Leu Thr Thr Glu Asn Gln Glu Met 
1               5                   10                  15      


Asp Lys Glu Glu Thr Lys Thr Lys Pro Arg Leu Leu Arg Tyr Glu Glu 
            20                  25                  30          


Lys Lys Tyr Glu Asp Val Lys Pro Leu Glu Thr Gln Pro Ala Glu Ile 
        35                  40                  45              


Ala Glu Lys Glu Thr Leu Glu Tyr Lys Thr Val Arg Thr Phe Ser Glu 
    50                  55                  60                  


Ser Leu Lys Ser Glu Lys Thr Glu Asp Tyr Leu Arg Glu Ser Ile Ile 
65                  70                  75                  80  


Gln Gln His Met Val Ser Pro Glu Pro Ala Ser Leu Lys Glu Lys Gly 
                85                  90                  95      


Lys Ser Arg Arg Lys Lys Asp Gln Thr His Ala Cys Pro Asn Val Arg 
            100                 105                 110         


Lys Ala Arg Pro Val Ser Tyr Asp Arg Thr Glu Pro Lys Asp Asp Asp 
        115                 120                 125             


Val Ile Arg Asn Ile Ile Arg Leu Arg Glu Lys Leu Gly Trp Gln Thr 
    130                 135                 140                 


Ile Leu Pro Gln His Ser Leu Lys Tyr Gly Ser Ser Lys Ile Ala Ile 
145                 150                 155                 160 


Gln Lys Ile Thr Leu Lys Lys Pro Leu Glu Asp Asp Gly Glu Phe Val 
                165                 170                 175     


Tyr Cys Leu Pro Arg Lys Ser Pro Lys Ser Leu Tyr Asn Pro Tyr Asp 
            180                 185                 190         


Leu Gln Val Val Ser Ala His Thr Ala Lys His Cys Lys Glu Phe Trp 
        195                 200                 205             


Val Ile Thr Ala Ser Phe Ile Ser Lys Val Ile Asn Ile Val Gly Ser 
    210                 215                 220                 


Val Lys Glu Val Glu Leu Ile Pro Thr Leu Glu Trp Leu Ser Glu Arg 
225                 230                 235                 240 


Arg His Tyr Tyr Leu Leu Arg Gln Phe Lys Ile Phe Ser Asp Phe Arg 
                245                 250                 255     


Met Asn Lys Ala Phe Val Thr Trp Lys Leu Asn Val Lys Arg Ile Lys 
            260                 265                 270         


Thr Glu Lys Ser Arg Ser Phe Leu Tyr His His Leu Phe Leu Ala Asp 
        275                 280                 285             


Asp Leu Phe Gln Thr Cys Leu Val Tyr Ile Arg Gly Leu Cys Glu Asp 
    290                 295                 300                 


Ala Ile Asn Leu Lys Asn Tyr Asn Asp His Glu Asn Asn Leu Ser Ala 
305                 310                 315                 320 


Ile Cys Leu Val Lys Leu Asp Ser Ser Arg Thr Tyr Ser Leu Asp Glu 
                325                 330                 335     


Phe Cys Glu Glu Gln Leu Gln Gln Ala Thr Gln Ala Leu Lys Gln Leu 
            340                 345                 350         


Glu Asp Ile Arg Asn Lys Ala Ile Ser Glu Met Lys Ser Thr Phe Leu 
        355                 360                 365             


Lys Val Ala Glu Lys Asn Glu Ile Lys Glu Tyr Phe Glu Ser Lys Leu 
    370                 375                 380                 


Ser Glu Asp Asp Thr Thr His Phe Lys Leu Pro Lys Tyr Arg Arg Leu 
385                 390                 395                 400 


Leu Glu Thr Phe Phe Lys Phe Val Met Leu Val Asp Tyr Ile Phe Gln 
                405                 410                 415     


Glu Leu Ile Arg Gln Leu Met Asn Thr Ala Val Thr Leu Leu Leu Glu 
            420                 425                 430         


Leu Phe Asn Gly Ser Ala Gly Met Pro Phe Ser Val Glu Lys Lys Asn 
        435                 440                 445             


Glu Asn Leu Ile Arg Thr Phe Lys Asp Asn Ser Phe Pro Thr Gly Lys 
    450                 455                 460                 


Thr Thr Asn Asp Cys Glu Glu Leu Val Asp Asn Ser Lys Leu His Ala 
465                 470                 475                 480 


Ile Ser Val Gln Lys Ser Glu Val Lys Thr Asp Thr Asp Ile Asn Glu 
                485                 490                 495     


Ile Leu Asn Ser Val Glu Val Gly Lys Asp Leu Arg Lys Thr Tyr Ala 
            500                 505                 510         


Pro Ile Phe Glu Val Asn Leu Cys Leu Arg Ile Pro Ala Glu Ser Asp 
        515                 520                 525             


Ser Ser Glu Asn Ser Lys Glu Asn Phe His Glu Ser Asp Gln Cys Pro 
    530                 535                 540                 


Glu Glu Cys Val Met Phe Glu Asp Glu Met Ser Glu Asn Lys Asp Asn 
545                 550                 555                 560 


Cys Val Lys Lys His Ser Ser Glu Glu Leu Leu Pro Lys Ala Lys Lys 
                565                 570                 575     


Ser Lys Glu Ile Ser Tyr Asn Leu Glu Asp Ile Ile Ser Asp Thr Glu 
            580                 585                 590         


Ile Glu Thr Glu Phe Glu Asn Lys Tyr Met Tyr Tyr Glu Phe Pro Glu 
        595                 600                 605             


Phe Pro Thr Asn Leu Phe Ile Asp Pro Asn Arg Leu Glu Phe Ser Val 
    610                 615                 620                 


Lys Ile Gln Asn Met Leu Thr Asn Met Glu Lys Cys Ile Thr Thr Ile 
625                 630                 635                 640 


Thr Pro Leu Cys Gln Asp Pro Gln Leu Ser Ile Phe Ile Asp Leu Val 
                645                 650                 655     


Ser Ile Met Asp Leu Pro Asn Lys Thr Gly Ser Ile Ile His Tyr Lys 
            660                 665                 670         


Glu Gln Thr Arg Trp Pro Asp Cys His Ile Leu Phe Glu Thr Asp Pro 
        675                 680                 685             


Ala Tyr Gln Asn Ile Ile Val Asn Leu Leu Thr Ile Ile Gly Asn Ser 
    690                 695                 700                 


Met Gly Leu Val Asn Ala Tyr Ser His Lys Phe Ile Lys Tyr Cys Thr 
705                 710                 715                 720 


Met Thr Glu Lys Ala Lys Ile Met Ser Met Lys Ile Ser Ser Met Gly 
                725                 730                 735     


Glu Leu Thr Ser Lys Glu Phe Glu Ala Ile Leu Asn Arg Phe Arg Asn 
            740                 745                 750         


Tyr Phe Arg His Ile Val Asn Met Ala Ile Glu Lys Arg Ile Gly Ile 
        755                 760                 765             


Phe Asn Val Val Ser Leu Asp Tyr Gln Ser Glu Cys Leu Leu Tyr Ile 
    770                 775                 780                 


Asp Asn Val Ile His Met Ser His Thr Leu Ile Gln Ser Val Ile Glu 
785                 790                 795                 800 


Lys Lys Asn Lys Asn Leu Leu Glu Val Val Glu Ser Ser Leu Gln Gln 
                805                 810                 815     


Leu Glu Cys Asp Pro Thr Glu Ile Glu Glu Phe Leu Glu His Phe Ile 
            820                 825                 830         


Phe Leu Asn Ala Ile Ser Ser Lys Ile Ser Lys Leu Glu Lys Glu Phe 
        835                 840                 845             


Leu Thr Met Ser Gln Leu Tyr Ser Val Ala Lys His His Gln Ile His 
    850                 855                 860                 


Ile Ser Glu Glu Gln Ile Ala Ile Phe Gln Val Leu Leu Leu Lys Phe 
865                 870                 875                 880 


Ser Gln Leu Lys Ser Ser Met Lys Leu Ser Lys Ile Asn Lys Asp Thr 
                885                 890                 895     


Ala Ile Thr Lys Phe Arg Asp Asn Leu Glu Ala Cys Ile Ser Gly Leu 
            900                 905                 910         


His Val Asp Val Gly Asn Leu Lys Ala Lys Ile Arg Thr Pro Leu Leu 
        915                 920                 925             


Leu Cys Ala Gly Thr Gln Val Ser Thr Ala Met Glu Met Ile Gln Thr 
    930                 935                 940                 


Leu Ser Gly Glu Ala Ala Ser Leu Thr Asn Lys Ala Lys Ala Tyr Ser 
945                 950                 955                 960 


His Tyr Gln Asp Cys Phe Ser Asp Ser Gln Ser His Met His Ser Val 
                965                 970                 975     


Asn Val Glu Glu Ile Thr Gln Ile Val Leu Ser Glu Ile Ser Asp Ile 
            980                 985                 990         


Glu Gly Asp Leu Thr Leu Arg Lys  Lys Leu Trp Glu Ala  Gln Glu Glu 
        995                 1000                 1005             


Trp Lys  Arg Ala Ser Trp Glu  Trp Arg Asn Ser Ser  Leu Gln Ser 
    1010                 1015                 1020             


Ile Asp  Val Glu Ser Val Gln  Arg Asn Val Ser Lys  Leu Met His 
    1025                 1030                 1035             


Ile Ile  Ser Val Leu Glu Lys  Gly Leu Pro Lys Ser  Asp Met Val 
    1040                 1045                 1050             


Thr His  Leu Lys Gln Val Val  Thr Glu Phe Lys Gln  Glu Leu Pro 
    1055                 1060                 1065             


Ile Ile  Ile Ala Leu Gly Asn  Pro Cys Leu Lys Pro  Arg His Trp 
    1070                 1075                 1080             


Glu Ala  Leu Gln Glu Ile Ile  Gly Lys Ser Val Pro  Leu Asp Lys 
    1085                 1090                 1095             


Asn Cys  Lys Val Glu Asn Leu  Leu Ala Leu Lys Met  Phe Gln Tyr 
    1100                 1105                 1110             


Glu Asn  Glu Ile Asn Asp Met  Ser Thr Ser Ala Thr  Asn Glu Ala 
    1115                 1120                 1125             


Ala Leu  Glu Lys Met Leu Phe  Lys Ile Ile Asp Phe  Trp Asn Thr 
    1130                 1135                 1140             


Thr Pro  Leu Pro Leu Ile Leu  His His Thr Glu Ile  Tyr Ser Ile 
    1145                 1150                 1155             


Phe Ile  Ile Pro Ser Ile Asp  Asp Ile Ser Ala Gln  Leu Glu Glu 
    1160                 1165                 1170             


Ser Gln  Val Ile Leu Ala Thr  Ile Lys Gly Ser Pro  His Ile Gly 
    1175                 1180                 1185             


Pro Ile  Lys Asp Leu Val Asn  Glu Trp Asp Gln Asn  Leu Thr Leu 
    1190                 1195                 1200             


Phe Ser  Tyr Thr Leu Glu Glu  Trp Met Asn Cys Gln  Arg Asn Trp 
    1205                 1210                 1215             


Leu Tyr  Leu Glu Pro Val Phe  His Ser Ser Glu Ile  Arg Arg Gln 
    1220                 1225                 1230             


Leu Pro  Ala Glu Thr Glu Leu  Phe Ser Gln Val Ile  Ser Met Trp 
    1235                 1240                 1245             


Lys Lys  Ile Met Ser Lys Ile  Gln Asn Lys Gln Asn  Ala Leu Gln 
    1250                 1255                 1260             


Ile Thr  Thr Ser Ala Gly Val  Leu Glu Ile Leu Gln  Asn Cys Asn 
    1265                 1270                 1275             


Ile His  Leu Glu His Ile Lys  Lys Ser Leu Glu Asp  Tyr Leu Glu 
    1280                 1285                 1290             


Val Lys  Arg Leu Ile Phe Pro  Arg Phe Tyr Phe Leu  Ser Asn Ala 
    1295                 1300                 1305             


Glu Leu  Leu Asp Ile Leu Ala  Asp Ser Arg Asn Pro  Glu Ser Val 
    1310                 1315                 1320             


Gln Pro  His Leu Val Lys Cys  Phe Glu Asn Ile Lys  Gln Leu Leu 
    1325                 1330                 1335             


Ile Trp  Lys Gln Asp Ile Gly  Pro Pro Ala Val Lys  Met Leu Ile 
    1340                 1345                 1350             


Ser Ala  Glu Gly Glu Gly Leu  Val Leu Pro Lys Lys  Ile Arg Val 
    1355                 1360                 1365             


Arg Ser  Ala Val Glu Gln Trp  Leu Val Asn Val Glu  Lys Ser Met 
    1370                 1375                 1380             


Phe Asp  Val Leu Lys Lys Glu  Arg Tyr Ile Tyr Asn  Ile Ile Leu 
    1385                 1390                 1395             


Leu Phe  Gln Ser Gln Ile Met  Phe Tyr Asn Asp Cys  Val Lys Ser 
    1400                 1405                 1410             


Phe Val  Ser Ser Tyr Ser Arg  Glu Lys Leu Glu Lys  Val His Ala 
    1415                 1420                 1425             


Gly Leu  Met Cys His Leu Glu  Glu Val Ala Asp Leu  Val Val Leu 
    1430                 1435                 1440             


Asp Thr  Ser Asn Ser Arg Thr  Lys Ala Ile Leu Gly  Ala Leu Leu 
    1445                 1450                 1455             


Ile Leu  Tyr Val His Cys Arg  Asp Ile Val Ile Asn  Leu Leu Leu 
    1460                 1465                 1470             


Lys Asn  Ile Phe Asn Ala Glu  Asp Phe Glu Trp Thr  Arg His Leu 
    1475                 1480                 1485             


Gln Tyr  Lys Trp Asn Glu Lys  Gln Lys Leu Cys Tyr  Val Ser Gln 
    1490                 1495                 1500             


Gly Asn  Ala Ser Phe Thr Tyr  Gly Tyr Glu Tyr Leu  Gly Cys Thr 
    1505                 1510                 1515             


Ser Arg  Leu Val Ile Thr Pro  Leu Thr Asp Arg Cys  Trp Leu Thr 
    1520                 1525                 1530             


Leu Met  Glu Ala Leu His Leu  Asn Leu Gly Gly Cys  Pro Ala Gly 
    1535                 1540                 1545             


Pro Ala  Gly Thr Gly Lys Thr  Glu Thr Val Lys Asp  Leu Ala Lys 
    1550                 1555                 1560             


Ser Leu  Gly Lys His Cys Val  Val Phe Asn Cys Phe  Glu Asp Leu 
    1565                 1570                 1575             


Asp Tyr  Lys Ile Val Arg Lys  Phe Phe Phe Gly Leu  Val Gln Ser 
    1580                 1585                 1590             


Gly Ala  Trp Ser Cys Phe Asp  Glu Phe Asn Leu Ile  Asp Leu Glu 
    1595                 1600                 1605             


Val Leu  Ser Val Ile Ala Ser  Gln Ile Leu Thr Ile  Lys Ala Ala 
    1610                 1615                 1620             


Lys Asp  Asn Tyr Ser Ala Arg  Phe Val Leu Glu Gly  Lys Glu Ile 
    1625                 1630                 1635             


Arg Ile  Asn Met Ser Cys Ala  Val Phe Ile Thr Met  Asn Pro Arg 
    1640                 1645                 1650             


Tyr Gly  Gly Gly Val Glu Leu  Pro Asp Asn Leu Lys  Ser Leu Phe 
    1655                 1660                 1665             


Arg Pro  Val Ala Met Met Val  Pro His Tyr Gln Met  Ile Ala Glu 
    1670                 1675                 1680             


Ile Ile  Leu Phe Ser Phe Gly  Phe Lys Ser Ala Asn  Ser Leu Ser 
    1685                 1690                 1695             


Gly Lys  Leu Thr Asn Leu Tyr  Glu Leu Ala Arg Lys  Gln Leu Ser 
    1700                 1705                 1710             


Gln Gln  Asp His Tyr Asn Phe  Gly Leu Arg Ser Leu  Lys Ile Val 
    1715                 1720                 1725             


Leu Ile  Met Ala Gly Thr Lys  Lys Arg Glu Phe Lys  Cys Leu Ser 
    1730                 1735                 1740             


Glu Ala  Asp Glu Thr Leu Ile  Val Ile Glu Ala Ile  Arg Glu Ala 
    1745                 1750                 1755             


Ser Leu  Pro Lys Cys Pro Pro  Glu Asp Val Pro Leu  Phe Glu Asn 
    1760                 1765                 1770             


Ile Ile  Gly Asp Ile Phe Pro  Glu Val Thr Val Leu  Lys Val Asn 
    1775                 1780                 1785             


Gln Leu  Ala Leu Glu Lys Val  Ile Tyr Thr Ala Thr  Gln Gln Leu 
    1790                 1795                 1800             


Gly Leu  Gln Asn Trp Ser Ser  Gln Lys Glu Lys Ile  Ile Gln Phe 
    1805                 1810                 1815             


Tyr Asn  Gln Leu Gln Val Cys  Val Gly Val Met Leu  Val Gly Pro 
    1820                 1825                 1830             


Thr Gly  Gly Gly Lys Thr Thr  Val Arg Arg Ile Leu  Glu Lys Ala 
    1835                 1840                 1845             


Leu Thr  Leu Leu Pro Ile Ala  Asp Phe Leu Ser Val  Ala Glu Arg 
    1850                 1855                 1860             


Lys Ser  Ala Ser Lys Ile Ser  Glu Arg Lys Gly Lys  Val Asp Ile 
    1865                 1870                 1875             


Cys Val  Leu Asn Pro Lys Cys  Val Thr Leu Ser Glu  Leu Tyr Gly 
    1880                 1885                 1890             


Gln Leu  Asp Pro Asn Thr Met  Glu Trp Thr Asp Gly  Leu Leu Ser 
    1895                 1900                 1905             


Ala Thr  Ile Arg Ser Tyr Val  Tyr Phe Asn Thr Pro  Lys Asn Thr 
    1910                 1915                 1920             


Lys Lys  Asp Ile Asp Leu Arg  Leu Lys Ser Arg Ile  Ser Asp Leu 
    1925                 1930                 1935             


Ser Asn  Val Phe Lys Leu Asp  Ser Ser Asp Thr Thr  Glu Thr Asp 
    1940                 1945                 1950             


Asp Asn  Ile Phe Glu Glu Ile  Glu Lys Val Val Lys  Ile Pro Glu 
    1955                 1960                 1965             


Asn His  Asn Phe Asp Trp Gln  Trp Ile Ile Leu Asp  Gly Pro Val 
    1970                 1975                 1980             


Asp Thr  Phe Trp Val Glu Asn  Leu Asn Ser Val Leu  Asp Asp Thr 
    1985                 1990                 1995             


Arg Thr  Leu Cys Leu Ala Asn  Ser Glu Arg Ile Ala  Leu Thr Asn 
    2000                 2005                 2010             


Lys Ile  Arg Val Ile Phe Glu  Val Asp Asn Leu Ser  Gln Ala Ser 
    2015                 2020                 2025             


Pro Ala  Thr Val Ser Arg Cys  Ala Met Val Tyr Met  Asp Pro Val 
    2030                 2035                 2040             


Asp Leu  Gly Trp Glu Pro Tyr  Val Lys Ser Trp Leu  Leu Lys Thr 
    2045                 2050                 2055             


Ser Lys  Ile Ile Ser Gln Ser  Gly Val Asp Cys Leu  Glu Phe Met 
    2060                 2065                 2070             


Ile Lys  Asn Ser Val Thr Asp  Gly Leu Gln Phe Ile  Arg Asn Arg 
    2075                 2080                 2085             


Gln Lys  Phe Gln Pro Tyr Pro  Met Glu Asp Ile Thr  Val Val Ile 
    2090                 2095                 2100             


Thr Leu  Cys Arg Ile Leu Asp  Ala Phe Phe Asp Phe  Met Gly Lys 
    2105                 2110                 2115             


Asn Gly  Gly Phe Glu Gln Ser  Asp Asp Leu Asn Asp  Thr Ser Ser 
    2120                 2125                 2130             


Lys Glu  Ala Asn Ser Gln Arg  Glu Ser Val Thr Phe  Lys Asp Ile 
    2135                 2140                 2145             


Glu Lys  Arg Asp Glu Asn Thr  Trp Tyr Pro Glu Lys  Asn Pro Asp 
    2150                 2155                 2160             


Lys Leu  Thr Lys Ile Ile Gln  Lys Leu Phe Val Phe  Ala Phe Thr 
    2165                 2170                 2175             


Trp Ala  Phe Gly Gly Ala Leu  Asn Arg Glu Asp Glu  His Arg Glu 
    2180                 2185                 2190             


Asn Ile  Pro Phe Cys Pro Ser  Leu Glu Pro Asp Ser  Leu Ala Lys 
    2195                 2200                 2205             


Val Thr  Tyr Asp Phe Asp Lys  Leu Val His Glu Leu  Phe Gly Asn 
    2210                 2215                 2220             


Ser Ser  Gln Val Gly Trp Lys  His Trp Gly Gln Ser  Gln Gly Arg 
    2225                 2230                 2235             


Arg Arg  Lys Gly Asn Cys Ile  Asn Leu Pro Thr Gly  Glu Cys Ser 
    2240                 2245                 2250             


Ile Phe  Gly Tyr Phe Val Asp  Ile Glu Gln Cys Glu  Phe Ile Pro 
    2255                 2260                 2265             


Trp Ser  Asp Leu Val Pro Asn  Asp Gln Thr Leu Ile  Gln Arg Gly 
    2270                 2275                 2280             


Thr Ser  Leu Leu Thr Asn Leu  Gln Arg Ser Gly Gly  Asn Phe Leu 
    2285                 2290                 2295             


Lys Ile  Thr Glu Cys Gly Glu  Cys Ile Asn Tyr Thr  Ala Thr Arg 
    2300                 2305                 2310             


Asp Thr  Thr Cys Leu Ser Phe  Leu Met Ser Leu Leu  Leu Lys Asn 
    2315                 2320                 2325             


Ser Cys  Pro Val Leu Leu Thr  Gly Glu Ser Gly Val  Gly Lys Thr 
    2330                 2335                 2340             


Ala Ala  Ile Asn Gln Met Leu  Glu Lys Leu Glu Gly  Pro Gly Ala 
    2345                 2350                 2355             


Phe Asp  Ile Lys His Gly Ser  Ile Leu Gly Asp Thr  Leu Leu Tyr 
    2360                 2365                 2370             


Ser Glu  Ile Lys Lys Ser Ser  Ser Leu Lys Gln Asn  Ile Thr Ile 
    2375                 2380                 2385             


Leu Ile  Pro Glu Thr His Lys  Thr Ala Thr Gly Ser  Ser Asp Asn 
    2390                 2395                 2400             


Pro Thr  Lys Lys Pro Glu Val  Arg Thr Asn Lys Lys  Leu Leu Lys 
    2405                 2410                 2415             


Asn Asn  Asp His Lys Gly Val  Val Val Ser Thr Ile  Asn Phe Ser 
    2420                 2425                 2430             


Thr Asn  Val Thr Ala Ala Lys  Thr Lys Glu Met Ile  Leu Lys Lys 
    2435                 2440                 2445             


Leu Ile  Arg Arg Thr Lys Asp  Thr Leu Gly Ala Pro  Lys Asn Asn 
    2450                 2455                 2460             


Arg Ile  Leu Ile Phe Ile Asp  Asp Met Asn Met Pro  Val Ser Asp 
    2465                 2470                 2475             


Met Tyr  Gly Ala Gln Pro Pro  Leu Glu Leu Ile Arg  Gln Leu Leu 
    2480                 2485                 2490             


Asp Leu  Gly Gly Val Tyr Asp  Thr Glu Lys Asn Thr  Trp Lys Asn 
    2495                 2500                 2505             


Ile Gln  Asp Leu Ser Ile Val  Ala Ala Cys Val Pro  Val Val Asn 
    2510                 2515                 2520             


Asp Ile  Ser Pro Arg Leu Leu  Lys His Phe Ser Met  Leu Val Leu 
    2525                 2530                 2535             


Pro His  Pro Ser Gln Asp Ile  Leu Cys Thr Ile Phe  Gln Ala His 
    2540                 2545                 2550             


Leu Gly  Ile Tyr Phe Ser Ile  Asn Asn Phe Thr Pro  Glu Val Gln 
    2555                 2560                 2565             


Lys Ser  Lys Asp Gln Ile Ile  Ser Cys Ser Leu Ala  Ile Tyr His 
    2570                 2575                 2580             


Gln Val  Arg Gln Asn Met Leu  Pro Thr Pro Thr Lys  Cys His Tyr 
    2585                 2590                 2595             


Met Phe  Asn Leu Arg Asp Met  Phe Lys Leu Leu Leu  Gly Leu Leu 
    2600                 2605                 2610             


Gln Ala  Asp Arg Thr Val Val  Asn Ser Lys Glu Met  Ala Ala Leu 
    2615                 2620                 2625             


Leu Phe  Val His Glu Ala Thr  Arg Val Phe His Asp  Arg Leu Ile 
    2630                 2635                 2640             


Asp Phe  Thr Asp Lys Ser Leu  Phe Tyr Arg Leu Leu  Ser Arg Glu 
    2645                 2650                 2655             


Leu Glu  Asn Cys Phe Gln Ile  Gly Ile Asp Gly Cys  Gly Lys Lys 
    2660                 2665                 2670             


Thr Cys  Ala Thr Leu Ala Cys  Tyr Leu Thr Asp Asn  Lys Leu Tyr 
    2675                 2680                 2685             


Arg Val  Pro Ile Ser His Lys  Cys Ala Tyr Ile Glu  Phe Lys Glu 
    2690                 2695                 2700             


Val Phe  Lys Lys Val Phe Ile  His Ala Gly Leu Lys  Gly Lys Pro 
    2705                 2710                 2715             


Thr Val  Leu Met Val Pro Asn  Leu Asn Ile Glu Gln  Asp Ser Phe 
    2720                 2725                 2730             


Leu Glu  Asp Leu Asn Tyr Ile  Ile Ser Ser Gly Arg  Ile Pro Asp 
    2735                 2740                 2745             


Leu Phe  Glu Asn Val Glu Leu  Asp Ser Ile Ala Met  Lys Ile Arg 
    2750                 2755                 2760             


Tyr Leu  Thr Glu Gln Ser Gly  His Met Asp Asn Arg  Gln Ser Leu 
    2765                 2770                 2775             


Leu Ser  Phe Phe Gln Lys Arg  Ile Tyr Lys Asn Leu  His Ile Phe 
    2780                 2785                 2790             


Val Ile  Met Ser Pro Glu Gly  Pro Ser Phe Arg Gln  Asn Cys Arg 
    2795                 2800                 2805             


Val Tyr  Pro Ser Met Ile Ser  Ser Cys Thr Ile Asp  Trp Tyr Glu 
    2810                 2815                 2820             


Arg Trp  Pro Glu Glu Ala Leu  Leu Ile Val Ala Asn  Ser Phe Leu 
    2825                 2830                 2835             


Lys Glu  Lys Val Asn Phe Glu  Asn Arg Glu Asn Leu  Lys Glu Lys 
    2840                 2845                 2850             


Leu Ala  Pro Thr Cys Val Gln  Ile His Lys Ser Met  Lys Asp Leu 
    2855                 2860                 2865             


Asn Arg  Lys Tyr Phe Glu Glu  Thr Gly Arg Phe Tyr  Tyr Thr Thr 
    2870                 2875                 2880             


Pro Asn  Ser Tyr Leu Gln Phe  Met Glu Thr Phe Ala  His Ile Leu 
    2885                 2890                 2895             


Arg Ala  Arg Glu Glu Glu Met  Gln Thr Lys Arg Asp  Arg Phe His 
    2900                 2905                 2910             


Met Gly  Leu Ser Thr Ile Leu  Glu Ala Thr Thr Leu  Val Thr Glu 
    2915                 2920                 2925             


Met Gln  Glu Glu Leu Leu Ile  Leu Gly Pro Gln Val  Glu Gln Lys 
    2930                 2935                 2940             


Thr Lys  Glu Thr Glu Thr Leu  Met Glu Lys Leu Arg  Lys Asp Ser 
    2945                 2950                 2955             


Gln Val  Val Glu Lys Val Gln  Met Leu Val Lys Gln  Asp Glu Glu 
    2960                 2965                 2970             


Ile Val  Ala Glu Glu Val Arg  Ile Val Glu Asp Tyr  Ala Gln Lys 
    2975                 2980                 2985             


Thr Ala  Asn Glu Leu Lys Ser  Val Leu Pro Ala Phe  Asp Lys Ala 
    2990                 2995                 3000             


Ile Val  Ala Leu Asn Ala Leu  Asp Lys Ala Asp Val  Ala Glu Leu 
    3005                 3010                 3015             


Arg Val  Tyr Thr Arg Pro Pro  Phe Leu Val Leu Thr  Val Met Asn 
    3020                 3025                 3030             


Ala Val  Cys Ile Leu Leu Gln  Lys Lys Pro Asn Trp  Ala Thr Ala 
    3035                 3040                 3045             


Lys Leu  Leu Leu Ser Glu Thr  Gly Phe Leu Lys Lys  Leu Ile Asn 
    3050                 3055                 3060             


Leu Asp  Lys Asp Ser Ile Pro  Asp Lys Val Phe Val  Lys Leu Lys 
    3065                 3070                 3075             


Lys Ile  Val Thr Leu Pro Asp  Phe Asn Pro His Lys  Ile Ser Leu 
    3080                 3085                 3090             


Val Ser  Val Ala Cys Cys Ser  Leu Cys Gln Trp Val  Ile Ala Leu 
    3095                 3100                 3105             


Asn Asn  Tyr His Glu Val Gln  Lys Val Val Gly Pro  Lys Gln Ile 
    3110                 3115                 3120             


Gln Val  Ala Glu Ala Gln Asn  Val Leu Lys Ile Ala  Arg Gln Arg 
    3125                 3130                 3135             


Leu Ala  Glu Lys Gln Arg Gly  Leu Gln Leu Val Glu  Glu His Leu 
    3140                 3145                 3150             


Leu Phe  Leu Gln Ala Ala Tyr  Lys Asp Thr Val Ala  Glu Lys Gln 
    3155                 3160                 3165             


Leu Leu  Ala Asn Arg Lys Thr  Met Ala Ser Arg Arg  Phe Gln Cys 
    3170                 3175                 3180             


Ala Ser  Val Leu Leu Thr Val  Leu Glu Asp Glu Lys  Thr Arg Trp 
    3185                 3190                 3195             


Gln Glu  Thr Ile Asn Gln Ile  Asp Asn Lys Leu Glu  Gly Ile Leu 
    3200                 3205                 3210             


Gly Asp  Ile Leu Leu Ser Ala  Ala Cys Ile Val Tyr  Ser Gly Ile 
    3215                 3220                 3225             


Leu Thr  Pro Glu Phe Arg Gln  Leu Ile Val Asn Lys  Trp Glu Thr 
    3230                 3235                 3240             


Phe Cys  Ile Glu Asn Gly Ile  Ser Leu Ser Ser Lys  Phe Ser Leu 
    3245                 3250                 3255             


Ile Lys  Val Met Ala Gln Lys  Tyr Glu Ile Ser Arg  Trp His Asn 
    3260                 3265                 3270             


Gln Gly  Leu Pro His Gly Gln  Tyr Ser Val Glu Asn  Ala Ile Leu 
    3275                 3280                 3285             


Ile Lys  Asn Gly Gln Gln Trp  Pro Leu Leu Ile Asp  Pro His Arg 
    3290                 3295                 3300             


Gln Ala  His Lys Trp Ile Arg  Gln Met Glu Gly Ser  Arg Leu Gln 
    3305                 3310                 3315             


Lys Leu  Ser Ile Glu Asp Ser  Asn Tyr Thr Lys Lys  Ile Glu Asn 
    3320                 3325                 3330             


Ala Met  Lys Thr Gly Gly Ser  Val Leu Leu Gln Asn  Leu Leu Glu 
    3335                 3340                 3345             


Thr Leu  Ala Pro Gly Leu Lys  Ala Ile Leu Lys Lys  Asp Ile Tyr 
    3350                 3355                 3360             


Gln Lys  Lys Gly His Tyr Phe  Ile Arg Val Gly Asp  Ala Glu Phe 
    3365                 3370                 3375             


Glu Tyr  Asn Ser Asn Phe Arg  Leu Tyr Leu Ser Thr  Glu Ile Asp 
    3380                 3385                 3390             


Asn Pro  His Phe Leu Pro Ser  Val Tyr Asn Phe Val  Thr Met Ile 
    3395                 3400                 3405             


Asn Phe  Thr Val Thr Phe Gln  Gly Leu Gln Asp Gln  Leu Leu Ser 
    3410                 3415                 3420             


Thr Val  Val Thr His Glu Val  Pro His Leu Glu Asp  Gln Arg Ser 
    3425                 3430                 3435             


Lys Leu  Leu Glu Ser Ile Ser  Leu Asp Ala Ile Thr  Leu Glu Glu 
    3440                 3445                 3450             


Leu Glu  Glu Lys Thr Leu Asn  Leu Leu Gln Lys Ala  Leu Gly Ser 
    3455                 3460                 3465             


Ile Leu  Asp Asp Asp Lys Ile  Val Asp Thr Leu Arg  Lys Ser Lys 
    3470                 3475                 3480             


Met Thr  Ser Asn Glu Ile Ser  Lys Arg Ile Glu Ala  Thr Lys Lys 
    3485                 3490                 3495             


Ala Glu  Ser Glu Ile Gln Ala  Ile Arg Lys Asn Tyr  Leu Pro Ile 
    3500                 3505                 3510             


Ala Thr  Arg Gly Ala Leu Leu  Tyr Phe Leu Val Ala  Asp Leu Thr 
    3515                 3520                 3525             


Gln Ile  Asn Tyr Met Tyr Gln  Phe Ser Leu Asp Trp  Phe His Gln 
    3530                 3535                 3540             


Val Phe  Val Ser Ser Val Val  Ser Lys Ser Lys Glu  Gln Glu His 
    3545                 3550                 3555             


Ser Phe  Lys Arg Glu Lys Val  Ser Pro Lys Glu Val  His Glu Phe 
    3560                 3565                 3570             


Ile Ser  Ile Ser Lys Glu Pro  Asn Leu Glu Asn Glu  Lys Asn Leu 
    3575                 3580                 3585             


Leu Asp  Lys His Ile Lys Ser  Ala Ile Asp Met Leu  Thr Lys Ser 
    3590                 3595                 3600             


Ile Phe  Lys Val Val Ser Ser  Ala Leu Phe Asn Glu  Asp Lys Leu 
    3605                 3610                 3615             


Cys Phe  Ser Phe Arg Leu Cys  Thr Val Ile Met Gln  Asn Asn Ala 
    3620                 3625                 3630             


Asn Gly  Asn Leu Ile Gln Asp  Asp Ile Gly Phe Leu  Pro Glu Glu 
    3635                 3640                 3645             


Glu Trp  Asn Ile Phe Leu Tyr  Ser Gly Ile Leu Ile  Asn Ile Lys 
    3650                 3655                 3660             


Ser Ala  Leu Ser Gln Ser Arg  Leu Thr Ser Thr Phe  Glu Ile Gly 
    3665                 3670                 3675             


Glu Ser  Gln His Leu Gln Trp  Leu Ser Asp Ser Arg  Trp Arg Gln 
    3680                 3685                 3690             


Cys Gln  Tyr Val Ser Thr His  Leu Glu Pro Phe Ser  Leu Leu Cys 
    3695                 3700                 3705             


Lys Ser  Leu Leu Ser Asn Val  Ser Gln Trp Asp Thr  Phe Lys Asn 
    3710                 3715                 3720             


Ser Lys  Ala Val Tyr Ser Leu  Ile Ser Thr Pro Phe  Ser Ser Glu 
    3725                 3730                 3735             


Asn Ala  Ser Leu Glu Glu Asn  Thr Lys Pro Pro Glu  Glu Thr Glu 
    3740                 3745                 3750             


Leu Leu  Asn Glu Asn Lys Glu  Thr Cys Asn Pro Ile  Asn Phe Pro 
    3755                 3760                 3765             


Trp Glu  Lys Leu Thr Ser Phe  Gln Arg Leu Ile Leu  Val Lys Val 
    3770                 3775                 3780             


Leu Arg  Pro Glu Ser Leu Asn  Asn Ser Val Arg Lys  Phe Ile Thr 
    3785                 3790                 3795             


Glu Lys  Met Gly Asn Lys Tyr  Leu Gln Arg Thr Gly  Val Asn Leu 
    3800                 3805                 3810             


Lys Asp  Ala Tyr Lys Gly Ser  Asn Ala Arg Thr Pro  Leu Ile Leu 
    3815                 3820                 3825             


Ile Gln  Thr His Gly Ile Asp  Leu Thr Asn Ile Leu  Leu Arg Phe 
    3830                 3835                 3840             


Ala Gln  Glu Leu Lys Gly Thr  Thr His His Val Thr  Ile Ile Ser 
    3845                 3850                 3855             


Leu Gly  Arg Asp Gln Ala Ala  Lys Ala Glu Asp Leu  Ile Leu Lys 
    3860                 3865                 3870             


Ala Leu  Thr Lys Thr Gln Gln  Trp Val Phe Leu Gln  Asn Cys His 
    3875                 3880                 3885             


Leu Ala  Thr Ser Phe Met Pro  Arg Leu Cys Thr Ile  Val Glu Ser 
    3890                 3895                 3900             


Phe Asn  Ser Pro Asn Val Thr  Ile Asp Pro Glu Phe  Arg Leu Trp 
    3905                 3910                 3915             


Leu Ser  Ser Lys Ser Tyr Ser  Ser Phe Pro Ile Pro  Val Leu Lys 
    3920                 3925                 3930             


Lys Gly  Leu Lys Ile Ala Val  Glu Ser Pro Gln Gly  Leu Lys Ser 
    3935                 3940                 3945             


Asn Leu  Leu Gln Thr Phe Gly  Cys Thr Gly Ser Gly  Glu Val Thr 
    3950                 3955                 3960             


Glu Glu  Ile Phe Glu Asn Pro  Asp Cys Gly Gln Trp  Trp Lys Lys 
    3965                 3970                 3975             


Leu Leu  Phe Ser Leu Cys Phe  Phe Asn Ala Val Ile  Asn Glu Arg 
    3980                 3985                 3990             


Lys Asn  Tyr Gly Ile Leu Gly  Trp Asn Ile Ala Tyr  Lys Phe Asn 
    3995                 4000                 4005             


Ser Ser  Asp Leu Gly Val Ala  Ile Lys Val Leu Glu  Asn Ser Leu 
    4010                 4015                 4020             


Arg Gly  Gln Pro Ser Ile Ser  Trp Gln Ala Leu Arg  Tyr Leu Ile 
    4025                 4030                 4035             


Gly Glu  Val Ile Tyr Gly Gly  Arg Val Ile Asp Asn  Trp Asp Lys 
    4040                 4045                 4050             


Arg Cys  Leu Lys Thr Leu Leu  Tyr Lys Phe Cys Asn  Pro Glu Val 
    4055                 4060                 4065             


Leu Lys  Asp Asp Phe Ser Phe  Ser Arg Ser Ala Ser  Ile Lys Asp 
    4070                 4075                 4080             


Tyr Ile  His Ile Ile Gln Ser  Leu Pro Asp Asp Asp  Leu Pro Glu 
    4085                 4090                 4095             


Val Leu  Gly Ile His Pro Glu  Ala Ile Arg Ser Cys  Trp Glu Thr 
    4100                 4105                 4110             


Gln Gly  Glu Lys Phe Ile Glu  Asn Leu Ile Ala Met  Gln Pro Lys 
    4115                 4120                 4125             


Thr Thr  Thr Ala Asn Leu Met  Ile Arg Pro Glu Gln  Ser Lys Asp 
    4130                 4135                 4140             


Glu Leu  Val Met Glu Ile Leu  Ser Asp Leu Leu Lys  Arg Leu Pro 
    4145                 4150                 4155             


Leu Thr  Val Glu Lys Glu Glu  Ile Ala Val Gly Thr  Pro Ser Thr 
    4160                 4165                 4170             


Leu Lys  Ser Met Met Ser Ser  Ser Ile Trp Glu Ser  Leu Ser Lys 
    4175                 4180                 4185             


Asn Leu  Lys Asp His Asp Pro  Leu Ile His Cys Val  Leu Leu Thr 
    4190                 4195                 4200             


Phe Leu  Lys Gln Glu Ile Lys  Arg Phe Asp Lys Leu  Leu Phe Val 
    4205                 4210                 4215             


Ile His  Lys Ser Leu Lys Asp  Leu Gln Leu Ala Ile  Lys Gly Glu 
    4220                 4225                 4230             


Ile Ile  Leu Thr Gln Glu Leu  Glu Glu Ile Phe Asn  Ser Phe Leu 
    4235                 4240                 4245             


Asn Met  Arg Val Pro Thr Leu  Trp Gln Lys His Ala  Tyr Arg Ser 
    4250                 4255                 4260             


Cys Lys  Pro Leu Ser Ser Trp  Ile Asp Asp Leu Ile  Gln Arg Leu 
    4265                 4270                 4275             


Asn Phe  Phe Asn Thr Trp Ala  Lys Val Ala Tyr Thr  Ala Ile Gln 
    4280                 4285                 4290             


Arg Arg  Tyr Met Arg Phe Val  Thr Val Trp Lys Gln  Ser Ile Pro 
    4295                 4300                 4305             


Ser Thr  Ser Gln Lys Cys Lys  His Pro Glu Asp Ser  Glu Asn Asn 
    4310                 4315                 4320             


Phe Phe  Glu Gly Phe Pro Ser  Arg Tyr Trp Leu Pro  Ala Phe Phe 
    4325                 4330                 4335             


Phe Pro  Gln Ala Phe Leu Ala  Ala Val Leu Gln Asp  Tyr Gly Arg 
    4340                 4345                 4350             


Ser Arg  Gly Ile Ala Val Asp  Ala Leu Thr Phe Thr  His His Val 
    4355                 4360                 4365             


Ile Ser  Asn Thr Thr Asp Lys  Asp Glu Lys Phe Ser  Val Phe Met 
    4370                 4375                 4380             


Pro Lys  Lys Leu Asn Ile Val  Arg Arg Ala Phe Lys  Gly Ser Ala 
    4385                 4390                 4395             


Ser Ser  His Thr Gly Val Tyr  Ile Phe Gly Leu Phe  Ile Glu Gly 
    4400                 4405                 4410             


Ala Arg  Trp Asn Arg Glu Gln  Lys Ile Leu Glu Asp  Ser Leu Pro 
    4415                 4420                 4425             


Leu Glu  Met Cys Cys Asp Phe  Pro Asp Ile Tyr Phe  Leu Pro Thr 
    4430                 4435                 4440             


Lys Ile  Ser Thr Lys Thr Pro  Asn Ala Ser Asn Gln  Thr Asp Ser 
    4445                 4450                 4455             


Glu Leu  Tyr Ala Phe Glu Cys  Pro Val Tyr Gln Thr  Pro Glu Arg 
    4460                 4465                 4470             


Ser Arg  Ile Leu Ala Thr Thr  Gly Leu Pro Thr Asn  Phe Leu Thr 
    4475                 4480                 4485             


Ser Val  Tyr Leu Ser Thr Lys  Lys Pro Pro Ser His  Trp Ile Thr 
    4490                 4495                 4500             


Met Arg  Val Ala Leu Leu Cys  Glu Lys Asn Glu Lys  
    4505                 4510                 4515 


<210>  4351
<211>  453
<212>  PRT
<213>  Homo Sapiens

<400>  4351

Met Glu Thr Phe Ile Pro Ile Asp Leu Thr Thr Glu Asn Gln Glu Met 
1               5                   10                  15      


Asp Lys Glu Glu Thr Lys Thr Lys Pro Arg Leu Leu Arg Tyr Glu Glu 
            20                  25                  30          


Lys Lys Tyr Glu Asp Val Lys Pro Leu Glu Thr Gln Pro Ala Glu Ile 
        35                  40                  45              


Ala Glu Lys Glu Thr Leu Glu Tyr Lys Thr Val Arg Thr Phe Ser Glu 
    50                  55                  60                  


Ser Leu Lys Ser Glu Lys Thr Glu Asp Tyr Leu Arg Glu Ser Ile Ile 
65                  70                  75                  80  


Gln Gln His Met Val Ser Pro Glu Pro Ala Ser Leu Lys Glu Lys Gly 
                85                  90                  95      


Lys Ser Arg Arg Lys Lys Asp Gln Thr His Ala Cys Pro Asn Val Arg 
            100                 105                 110         


Lys Ala Arg Pro Val Ser Tyr Asp Arg Thr Glu Pro Lys Asp Asp Asp 
        115                 120                 125             


Val Ile Arg Asn Ile Ile Arg Leu Arg Glu Lys Leu Gly Trp Gln Thr 
    130                 135                 140                 


Ile Leu Pro Gln His Ser Leu Lys Tyr Gly Ser Ser Lys Ile Ala Ile 
145                 150                 155                 160 


Gln Lys Ile Thr Leu Lys Lys Pro Leu Glu Asp Asp Gly Glu Phe Val 
                165                 170                 175     


Tyr Cys Leu Pro Arg Lys Ser Pro Lys Ser Leu Tyr Asn Pro Tyr Asp 
            180                 185                 190         


Leu Gln Val Val Ser Ala His Thr Ala Lys His Cys Lys Glu Phe Trp 
        195                 200                 205             


Val Ile Thr Ala Ser Phe Ile Ser Lys Val Ile Asn Ile Val Gly Ser 
    210                 215                 220                 


Val Lys Glu Val Glu Leu Ile Pro Thr Leu Glu Trp Leu Ser Glu Arg 
225                 230                 235                 240 


Arg His Tyr Tyr Leu Leu Arg Gln Phe Lys Ile Phe Ser Asp Phe Arg 
                245                 250                 255     


Met Asn Lys Ala Phe Val Thr Trp Lys Leu Asn Val Lys Arg Ile Lys 
            260                 265                 270         


Thr Glu Lys Ser Arg Ser Phe Leu Tyr His His Leu Phe Leu Ala Asp 
        275                 280                 285             


Asp Leu Phe Gln Thr Cys Leu Val Tyr Ile Arg Gly Leu Cys Glu Asp 
    290                 295                 300                 


Ala Ile Asn Leu Lys Asn Tyr Asn Asp His Glu Asn Asn Leu Ser Ala 
305                 310                 315                 320 


Ile Cys Leu Val Lys Leu Asp Ser Ser Arg Thr Tyr Ser Leu Asp Glu 
                325                 330                 335     


Phe Cys Glu Glu Gln Leu Gln Gln Ala Thr Gln Ala Leu Lys Gln Leu 
            340                 345                 350         


Glu Asp Ile Arg Asn Lys Ala Ile Ser Glu Met Lys Ser Thr Phe Leu 
        355                 360                 365             


Lys Val Ala Glu Lys Asn Glu Ile Lys Glu Tyr Phe Glu Ser Lys Leu 
    370                 375                 380                 


Ser Glu Asp Asp Thr Thr His Phe Lys Leu Pro Lys Tyr Arg Arg Leu 
385                 390                 395                 400 


Leu Glu Thr Phe Phe Lys Phe Val Met Leu Val Asp Tyr Ile Phe Gln 
                405                 410                 415     


Glu Leu Ile Arg Gln Leu Met Asn Thr Ala Val Thr Leu Leu Leu Glu 
            420                 425                 430         


Leu Phe Asn Gly Ser Ala Gly Met Pro Phe Ser Val Glu Lys Lys Asn 
        435                 440                 445             


Glu Asn Leu Ile Arg 
    450             


<210>  4352
<211>  4515
<212>  PRT
<213>  Homo Sapiens

<400>  4352

Met Glu Thr Phe Ile Pro Ile Asp Leu Thr Thr Glu Asn Gln Glu Met 
1               5                   10                  15      


Asp Lys Glu Glu Thr Lys Thr Lys Pro Arg Leu Leu Arg Tyr Glu Glu 
            20                  25                  30          


Lys Lys Tyr Glu Asp Val Lys Pro Leu Glu Thr Gln Pro Ala Glu Ile 
        35                  40                  45              


Ala Glu Lys Glu Thr Leu Glu Tyr Lys Thr Val Arg Thr Phe Ser Glu 
    50                  55                  60                  


Ser Leu Lys Ser Glu Lys Thr Glu Asp Tyr Leu Arg Glu Ser Ile Ile 
65                  70                  75                  80  


Gln Gln His Met Val Ser Pro Glu Pro Ala Ser Leu Lys Glu Lys Gly 
                85                  90                  95      


Lys Ser Arg Arg Lys Lys Asp Gln Thr His Ala Cys Pro Asn Val Arg 
            100                 105                 110         


Lys Ala Arg Pro Val Ser Tyr Asp Arg Thr Glu Pro Lys Asp Asp Asp 
        115                 120                 125             


Val Ile Arg Asn Ile Ile Arg Leu Arg Glu Lys Leu Gly Trp Gln Thr 
    130                 135                 140                 


Ile Leu Pro Gln His Ser Leu Lys Tyr Gly Ser Ser Lys Ile Ala Ile 
145                 150                 155                 160 


Gln Lys Ile Thr Leu Lys Lys Pro Leu Glu Asp Asp Gly Glu Phe Val 
                165                 170                 175     


Tyr Cys Leu Pro Arg Lys Ser Pro Lys Ser Leu Tyr Asn Pro Tyr Asp 
            180                 185                 190         


Leu Gln Val Val Ser Ala His Thr Ala Lys His Cys Lys Glu Phe Trp 
        195                 200                 205             


Val Ile Thr Ala Ser Phe Ile Ser Lys Val Ile Asn Ile Val Gly Ser 
    210                 215                 220                 


Val Lys Glu Val Glu Leu Ile Pro Thr Leu Glu Trp Leu Ser Glu Arg 
225                 230                 235                 240 


Arg His Tyr Tyr Leu Leu Arg Gln Phe Lys Ile Phe Ser Asp Phe Arg 
                245                 250                 255     


Met Asn Lys Ala Phe Val Thr Trp Lys Leu Asn Val Lys Arg Ile Lys 
            260                 265                 270         


Thr Glu Lys Ser Arg Ser Phe Leu Tyr His His Leu Phe Leu Ala Asp 
        275                 280                 285             


Asp Leu Phe Gln Thr Cys Leu Val Tyr Ile Arg Gly Leu Cys Glu Asp 
    290                 295                 300                 


Ala Ile Asn Leu Lys Asn Tyr Asn Asp His Glu Asn Asn Leu Ser Ala 
305                 310                 315                 320 


Ile Cys Leu Val Lys Leu Asp Ser Ser Arg Thr Tyr Ser Leu Asp Glu 
                325                 330                 335     


Phe Cys Glu Glu Gln Leu Gln Gln Ala Thr Gln Ala Leu Lys Gln Leu 
            340                 345                 350         


Glu Asp Ile Arg Asn Lys Ala Ile Ser Glu Met Lys Ser Thr Phe Leu 
        355                 360                 365             


Lys Val Ala Glu Lys Asn Glu Ile Lys Glu Tyr Phe Glu Ser Lys Leu 
    370                 375                 380                 


Ser Glu Asp Asp Thr Thr His Phe Lys Leu Pro Lys Tyr Arg Arg Leu 
385                 390                 395                 400 


Leu Glu Thr Phe Phe Lys Phe Val Met Leu Val Asp Tyr Ile Phe Gln 
                405                 410                 415     


Glu Leu Ile Arg Gln Leu Met Asn Thr Ala Val Thr Leu Leu Leu Glu 
            420                 425                 430         


Leu Phe Asn Gly Ser Ala Gly Met Pro Phe Ser Val Glu Lys Lys Asn 
        435                 440                 445             


Glu Asn Leu Ile Arg Thr Phe Lys Asp Asn Ser Phe Pro Thr Gly Lys 
    450                 455                 460                 


Thr Thr Asn Asp Cys Glu Glu Leu Val Asp Asn Ser Lys Leu His Ala 
465                 470                 475                 480 


Ile Ser Val Gln Lys Ser Glu Val Lys Thr Asp Thr Asp Ile Asn Glu 
                485                 490                 495     


Ile Leu Asn Ser Val Glu Val Gly Lys Asp Leu Arg Lys Thr Tyr Ala 
            500                 505                 510         


Pro Ile Phe Glu Val Asn Leu Cys Leu Arg Ile Pro Ala Glu Ser Asp 
        515                 520                 525             


Ser Ser Glu Asn Ser Lys Glu Asn Phe His Glu Ser Asp Gln Cys Pro 
    530                 535                 540                 


Glu Glu Cys Val Met Phe Glu Asp Glu Met Ser Glu Asn Lys Asp Asn 
545                 550                 555                 560 


Cys Val Lys Lys His Ser Ser Glu Glu Leu Leu Pro Lys Ala Lys Lys 
                565                 570                 575     


Ser Lys Glu Ile Ser Tyr Asn Leu Glu Asp Ile Ile Ser Asp Thr Glu 
            580                 585                 590         


Ile Glu Thr Glu Phe Glu Asn Lys Tyr Met Tyr Tyr Glu Phe Pro Glu 
        595                 600                 605             


Phe Pro Thr Asn Leu Phe Ile Asp Pro Asn Arg Leu Glu Phe Ser Val 
    610                 615                 620                 


Lys Ile Gln Asn Met Leu Thr Asn Met Glu Lys Cys Ile Thr Thr Ile 
625                 630                 635                 640 


Thr Pro Leu Cys Gln Asp Pro Gln Leu Ser Ile Phe Ile Asp Leu Val 
                645                 650                 655     


Ser Ile Met Asp Leu Pro Asn Lys Thr Gly Ser Ile Ile His Tyr Lys 
            660                 665                 670         


Glu Gln Thr Arg Trp Pro Asp Cys His Ile Leu Phe Glu Thr Asp Pro 
        675                 680                 685             


Ala Tyr Gln Asn Ile Ile Val Asn Leu Leu Thr Ile Ile Gly Asn Ser 
    690                 695                 700                 


Met Gly Leu Val Asn Ala Tyr Ser His Lys Phe Ile Lys Tyr Cys Thr 
705                 710                 715                 720 


Met Thr Glu Lys Ala Lys Ile Met Ser Met Lys Ile Ser Ser Met Gly 
                725                 730                 735     


Glu Leu Thr Ser Lys Glu Phe Glu Ala Ile Leu Asn Arg Phe Arg Asn 
            740                 745                 750         


Tyr Phe Arg His Ile Val Asn Met Ala Ile Glu Lys Arg Ile Gly Ile 
        755                 760                 765             


Phe Asn Val Val Ser Leu Asp Tyr Gln Ser Glu Cys Leu Leu Tyr Ile 
    770                 775                 780                 


Asp Asn Val Ile His Met Ser His Thr Leu Ile Gln Ser Val Ile Glu 
785                 790                 795                 800 


Lys Lys Asn Lys Asn Leu Leu Glu Val Val Glu Ser Ser Leu Gln Gln 
                805                 810                 815     


Leu Glu Cys Asp Pro Thr Glu Ile Glu Glu Phe Leu Glu His Phe Ile 
            820                 825                 830         


Phe Leu Asn Ala Ile Ser Ser Lys Ile Ser Lys Leu Glu Lys Glu Phe 
        835                 840                 845             


Leu Thr Met Ser Gln Leu Tyr Ser Val Ala Lys His His Gln Ile His 
    850                 855                 860                 


Ile Ser Glu Glu Gln Ile Ala Ile Phe Gln Val Leu Leu Leu Lys Phe 
865                 870                 875                 880 


Ser Gln Leu Lys Ser Ser Met Lys Leu Ser Lys Ile Asn Lys Asp Thr 
                885                 890                 895     


Ala Ile Thr Lys Phe Arg Asp Asn Leu Glu Ala Cys Ile Ser Gly Leu 
            900                 905                 910         


His Val Asp Val Gly Asn Leu Lys Ala Lys Ile Arg Thr Pro Leu Leu 
        915                 920                 925             


Leu Cys Ala Gly Thr Gln Val Ser Thr Ala Met Glu Met Ile Gln Thr 
    930                 935                 940                 


Leu Ser Gly Glu Ala Ala Ser Leu Thr Asn Lys Ala Lys Ala Tyr Ser 
945                 950                 955                 960 


His Tyr Gln Asp Cys Phe Ser Asp Ser Gln Ser His Met His Ser Val 
                965                 970                 975     


Asn Val Glu Glu Ile Thr Gln Ile Val Leu Ser Glu Ile Ser Asp Ile 
            980                 985                 990         


Glu Gly Asp Leu Thr Leu Arg Lys  Lys Leu Trp Glu Ala  Gln Glu Glu 
        995                 1000                 1005             


Trp Lys  Arg Ala Ser Trp Glu  Trp Arg Asn Ser Ser  Leu Gln Ser 
    1010                 1015                 1020             


Ile Asp  Val Glu Ser Val Gln  Arg Asn Val Ser Lys  Leu Met His 
    1025                 1030                 1035             


Ile Ile  Ser Val Leu Glu Lys  Gly Leu Pro Lys Ser  Asp Met Val 
    1040                 1045                 1050             


Thr His  Leu Lys Gln Val Val  Thr Glu Phe Lys Gln  Glu Leu Pro 
    1055                 1060                 1065             


Ile Ile  Ile Ala Leu Gly Asn  Pro Cys Leu Lys Pro  Arg His Trp 
    1070                 1075                 1080             


Glu Ala  Leu Gln Glu Ile Ile  Gly Lys Ser Val Pro  Leu Asp Lys 
    1085                 1090                 1095             


Asn Cys  Lys Val Glu Asn Leu  Leu Ala Leu Lys Met  Phe Gln Tyr 
    1100                 1105                 1110             


Glu Asn  Glu Ile Asn Asp Met  Ser Thr Ser Ala Thr  Asn Glu Ala 
    1115                 1120                 1125             


Ala Leu  Glu Lys Met Leu Phe  Lys Ile Ile Asp Phe  Trp Asn Thr 
    1130                 1135                 1140             


Thr Pro  Leu Pro Leu Ile Leu  His His Thr Glu Ile  Tyr Ser Ile 
    1145                 1150                 1155             


Phe Ile  Ile Pro Ser Ile Asp  Asp Ile Ser Ala Gln  Leu Glu Glu 
    1160                 1165                 1170             


Ser Gln  Val Ile Leu Ala Thr  Ile Lys Gly Ser Pro  His Ile Gly 
    1175                 1180                 1185             


Pro Ile  Lys Asp Leu Val Asn  Glu Trp Asp Gln Asn  Leu Thr Leu 
    1190                 1195                 1200             


Phe Ser  Tyr Thr Leu Glu Glu  Trp Met Asn Cys Gln  Arg Asn Trp 
    1205                 1210                 1215             


Leu Tyr  Leu Glu Pro Val Phe  His Ser Ser Glu Ile  Arg Arg Gln 
    1220                 1225                 1230             


Leu Pro  Ala Glu Thr Glu Leu  Phe Ser Gln Val Ile  Ser Met Trp 
    1235                 1240                 1245             


Lys Lys  Ile Met Ser Lys Ile  Gln Asn Lys Gln Asn  Ala Leu Gln 
    1250                 1255                 1260             


Ile Thr  Thr Ser Ala Gly Val  Leu Glu Ile Leu Gln  Asn Cys Asn 
    1265                 1270                 1275             


Ile His  Leu Glu His Ile Lys  Lys Ser Leu Glu Asp  Tyr Leu Glu 
    1280                 1285                 1290             


Val Lys  Arg Leu Ile Phe Pro  Arg Phe Tyr Phe Leu  Ser Asn Ala 
    1295                 1300                 1305             


Glu Leu  Leu Asp Ile Leu Ala  Asp Ser Arg Asn Pro  Glu Ser Val 
    1310                 1315                 1320             


Gln Pro  His Leu Val Lys Cys  Phe Glu Asn Ile Lys  Gln Leu Leu 
    1325                 1330                 1335             


Ile Trp  Lys Gln Asp Ile Gly  Pro Pro Ala Val Lys  Met Leu Ile 
    1340                 1345                 1350             


Ser Ala  Glu Gly Glu Gly Leu  Val Leu Pro Lys Lys  Ile Arg Val 
    1355                 1360                 1365             


Arg Ser  Ala Val Glu Gln Trp  Leu Val Asn Val Glu  Lys Ser Met 
    1370                 1375                 1380             


Phe Asp  Val Leu Lys Lys Glu  Arg Tyr Ile Tyr Asn  Ile Ile Leu 
    1385                 1390                 1395             


Leu Phe  Gln Ser Gln Ile Met  Phe Tyr Asn Asp Cys  Val Lys Ser 
    1400                 1405                 1410             


Phe Val  Ser Ser Tyr Ser Arg  Glu Lys Leu Glu Lys  Val His Ala 
    1415                 1420                 1425             


Gly Leu  Met Cys His Leu Glu  Glu Val Ala Asp Leu  Val Val Leu 
    1430                 1435                 1440             


Asp Thr  Ser Asn Ser Arg Thr  Lys Ala Ile Leu Gly  Ala Leu Leu 
    1445                 1450                 1455             


Ile Leu  Tyr Val His Cys Arg  Asp Ile Val Ile Asn  Leu Leu Leu 
    1460                 1465                 1470             


Lys Asn  Ile Phe Asn Ala Glu  Asp Phe Glu Trp Thr  Arg His Leu 
    1475                 1480                 1485             


Gln Tyr  Lys Trp Asn Glu Lys  Gln Lys Leu Cys Tyr  Val Ser Gln 
    1490                 1495                 1500             


Gly Asn  Ala Ser Phe Thr Tyr  Gly Tyr Glu Tyr Leu  Gly Cys Thr 
    1505                 1510                 1515             


Ser Arg  Leu Val Ile Thr Pro  Leu Thr Asp Arg Cys  Trp Leu Thr 
    1520                 1525                 1530             


Leu Met  Glu Ala Leu His Leu  Asn Leu Gly Gly Cys  Pro Ala Gly 
    1535                 1540                 1545             


Pro Ala  Gly Thr Gly Lys Thr  Glu Thr Val Lys Asp  Leu Ala Lys 
    1550                 1555                 1560             


Ser Leu  Gly Lys His Cys Val  Val Phe Asn Cys Phe  Glu Asp Leu 
    1565                 1570                 1575             


Asp Tyr  Lys Ile Val Arg Lys  Phe Phe Phe Gly Leu  Val Gln Ser 
    1580                 1585                 1590             


Gly Ala  Trp Ser Cys Phe Asp  Glu Phe Asn Leu Ile  Asp Leu Glu 
    1595                 1600                 1605             


Val Leu  Ser Val Ile Ala Ser  Gln Ile Leu Thr Ile  Lys Ala Ala 
    1610                 1615                 1620             


Lys Asp  Asn Tyr Ser Ala Arg  Phe Val Leu Glu Gly  Lys Glu Ile 
    1625                 1630                 1635             


Arg Ile  Asn Met Ser Cys Ala  Val Phe Ile Thr Met  Asn Pro Arg 
    1640                 1645                 1650             


Tyr Gly  Gly Gly Val Glu Leu  Pro Asp Asn Leu Lys  Ser Leu Phe 
    1655                 1660                 1665             


Arg Pro  Val Ala Met Met Val  Pro His Tyr Gln Met  Ile Ala Glu 
    1670                 1675                 1680             


Ile Ile  Leu Phe Ser Phe Gly  Phe Lys Ser Ala Asn  Ser Leu Ser 
    1685                 1690                 1695             


Gly Lys  Leu Thr Asn Leu Tyr  Glu Leu Ala Arg Lys  Gln Leu Ser 
    1700                 1705                 1710             


Gln Gln  Asp His Tyr Asn Phe  Gly Leu Arg Ser Leu  Lys Ile Val 
    1715                 1720                 1725             


Leu Ile  Met Ala Gly Thr Lys  Lys Arg Glu Phe Lys  Cys Leu Ser 
    1730                 1735                 1740             


Glu Ala  Asp Glu Thr Leu Ile  Val Ile Glu Ala Ile  Arg Glu Ala 
    1745                 1750                 1755             


Ser Leu  Pro Lys Cys Pro Pro  Glu Asp Val Pro Leu  Phe Glu Asn 
    1760                 1765                 1770             


Ile Ile  Gly Asp Ile Phe Pro  Glu Val Thr Val Leu  Lys Val Asn 
    1775                 1780                 1785             


Gln Leu  Ala Leu Glu Lys Val  Ile Tyr Thr Ala Thr  Gln Gln Leu 
    1790                 1795                 1800             


Gly Leu  Gln Asn Trp Ser Ser  Gln Lys Glu Lys Ile  Ile Gln Phe 
    1805                 1810                 1815             


Tyr Asn  Gln Leu Gln Val Cys  Val Gly Val Met Leu  Val Gly Pro 
    1820                 1825                 1830             


Thr Gly  Gly Gly Lys Thr Thr  Val Arg Arg Ile Leu  Glu Lys Ala 
    1835                 1840                 1845             


Leu Thr  Leu Leu Pro Ile Ala  Asp Phe Leu Ser Val  Ala Glu Arg 
    1850                 1855                 1860             


Lys Ser  Ala Ser Lys Ile Ser  Glu Arg Lys Gly Lys  Val Asp Ile 
    1865                 1870                 1875             


Cys Val  Leu Asn Pro Lys Cys  Val Thr Leu Ser Glu  Leu Tyr Gly 
    1880                 1885                 1890             


Gln Leu  Asp Pro Asn Thr Met  Glu Trp Thr Asp Gly  Leu Leu Ser 
    1895                 1900                 1905             


Ala Thr  Ile Arg Ser Tyr Val  Tyr Phe Asn Thr Pro  Lys Asn Thr 
    1910                 1915                 1920             


Lys Lys  Asp Ile Asp Leu Arg  Leu Lys Ser Arg Ile  Ser Asp Leu 
    1925                 1930                 1935             


Ser Asn  Val Phe Lys Leu Asp  Ser Ser Asp Thr Thr  Glu Thr Asp 
    1940                 1945                 1950             


Asp Asn  Ile Phe Glu Glu Ile  Glu Lys Val Val Lys  Ile Pro Glu 
    1955                 1960                 1965             


Asn His  Asn Phe Asp Trp Gln  Trp Ile Ile Leu Asp  Gly Pro Val 
    1970                 1975                 1980             


Asp Thr  Phe Trp Val Glu Asn  Leu Asn Ser Val Leu  Asp Asp Thr 
    1985                 1990                 1995             


Arg Thr  Leu Cys Leu Ala Asn  Ser Glu Arg Ile Ala  Leu Thr Asn 
    2000                 2005                 2010             


Lys Ile  Arg Val Ile Phe Glu  Val Asp Asn Leu Ser  Gln Ala Ser 
    2015                 2020                 2025             


Pro Ala  Thr Val Ser Arg Cys  Ala Met Val Tyr Met  Asp Pro Val 
    2030                 2035                 2040             


Asp Leu  Gly Trp Glu Pro Tyr  Val Lys Ser Trp Leu  Leu Lys Thr 
    2045                 2050                 2055             


Ser Lys  Ile Ile Ser Gln Ser  Gly Val Asp Cys Leu  Glu Phe Met 
    2060                 2065                 2070             


Ile Lys  Asn Ser Val Thr Asp  Gly Leu Gln Phe Ile  Arg Asn Arg 
    2075                 2080                 2085             


Gln Lys  Phe Gln Pro Tyr Pro  Met Glu Asp Ile Thr  Val Val Ile 
    2090                 2095                 2100             


Thr Leu  Cys Arg Ile Leu Asp  Ala Phe Phe Asp Phe  Met Gly Lys 
    2105                 2110                 2115             


Asn Gly  Gly Phe Glu Gln Ser  Asp Asp Leu Asn Asp  Thr Ser Ser 
    2120                 2125                 2130             


Lys Glu  Ala Asn Ser Gln Arg  Glu Ser Val Thr Phe  Lys Asp Ile 
    2135                 2140                 2145             


Glu Lys  Arg Asp Glu Asn Thr  Trp Tyr Pro Glu Lys  Asn Pro Asp 
    2150                 2155                 2160             


Lys Leu  Thr Lys Ile Ile Gln  Lys Leu Phe Val Phe  Ala Phe Thr 
    2165                 2170                 2175             


Trp Ala  Phe Gly Gly Ala Leu  Asn Arg Glu Asp Glu  His Arg Glu 
    2180                 2185                 2190             


Asn Ile  Pro Phe Cys Pro Ser  Leu Glu Pro Asp Ser  Leu Ala Lys 
    2195                 2200                 2205             


Val Thr  Tyr Asp Phe Asp Lys  Leu Val His Glu Leu  Phe Gly Asn 
    2210                 2215                 2220             


Ser Ser  Gln Val Gly Trp Lys  His Trp Gly Gln Ser  Gln Gly Arg 
    2225                 2230                 2235             


Arg Arg  Lys Gly Asn Cys Ile  Asn Leu Pro Thr Gly  Glu Cys Ser 
    2240                 2245                 2250             


Ile Phe  Gly Tyr Phe Val Asp  Ile Glu Gln Cys Glu  Phe Ile Pro 
    2255                 2260                 2265             


Trp Ser  Asp Leu Val Pro Asn  Asp Gln Thr Leu Ile  Gln Arg Gly 
    2270                 2275                 2280             


Thr Ser  Leu Leu Thr Asn Leu  Gln Arg Ser Gly Gly  Asn Phe Leu 
    2285                 2290                 2295             


Lys Ile  Thr Glu Cys Gly Glu  Cys Ile Asn Tyr Thr  Ala Thr Arg 
    2300                 2305                 2310             


Asp Thr  Thr Cys Leu Ser Phe  Leu Met Ser Leu Leu  Leu Lys Asn 
    2315                 2320                 2325             


Ser Cys  Pro Val Leu Leu Thr  Gly Glu Ser Gly Val  Gly Lys Thr 
    2330                 2335                 2340             


Ala Ala  Ile Asn Gln Met Leu  Glu Lys Leu Glu Gly  Pro Gly Ala 
    2345                 2350                 2355             


Phe Asp  Ile Lys His Gly Ser  Ile Leu Gly Asp Thr  Leu Leu Tyr 
    2360                 2365                 2370             


Ser Glu  Ile Lys Lys Ser Ser  Ser Leu Lys Gln Asn  Ile Thr Ile 
    2375                 2380                 2385             


Leu Ile  Pro Glu Thr His Lys  Thr Ala Thr Gly Ser  Ser Asp Asn 
    2390                 2395                 2400             


Pro Thr  Lys Lys Pro Glu Val  Arg Thr Asn Lys Lys  Leu Leu Lys 
    2405                 2410                 2415             


Asn Asn  Asp His Lys Gly Val  Val Val Ser Thr Ile  Asn Phe Ser 
    2420                 2425                 2430             


Thr Asn  Val Thr Ala Ala Lys  Thr Lys Glu Met Ile  Leu Lys Lys 
    2435                 2440                 2445             


Leu Ile  Arg Arg Thr Lys Asp  Thr Leu Gly Ala Pro  Lys Asn Asn 
    2450                 2455                 2460             


Arg Ile  Leu Ile Phe Ile Asp  Asp Met Asn Met Pro  Val Ser Asp 
    2465                 2470                 2475             


Met Tyr  Gly Ala Gln Pro Pro  Leu Glu Leu Ile Arg  Gln Leu Leu 
    2480                 2485                 2490             


Asp Leu  Gly Gly Val Tyr Asp  Thr Glu Lys Asn Thr  Trp Lys Asn 
    2495                 2500                 2505             


Ile Gln  Asp Leu Ser Ile Val  Ala Ala Cys Val Pro  Val Val Asn 
    2510                 2515                 2520             


Asp Ile  Ser Pro Arg Leu Leu  Lys His Phe Ser Met  Leu Val Leu 
    2525                 2530                 2535             


Pro His  Pro Ser Gln Asp Ile  Leu Cys Thr Ile Phe  Gln Ala His 
    2540                 2545                 2550             


Leu Gly  Ile Tyr Phe Ser Ile  Asn Asn Phe Thr Pro  Glu Val Gln 
    2555                 2560                 2565             


Lys Ser  Lys Asp Gln Ile Ile  Ser Cys Ser Leu Ala  Ile Tyr His 
    2570                 2575                 2580             


Gln Val  Arg Gln Asn Met Leu  Pro Thr Pro Thr Lys  Cys His Tyr 
    2585                 2590                 2595             


Met Phe  Asn Leu Arg Asp Met  Phe Lys Leu Leu Leu  Gly Leu Leu 
    2600                 2605                 2610             


Gln Ala  Asp Arg Thr Val Val  Asn Ser Lys Glu Met  Ala Ala Leu 
    2615                 2620                 2625             


Leu Phe  Val His Glu Ala Thr  Arg Val Phe His Asp  Arg Leu Ile 
    2630                 2635                 2640             


Asp Phe  Thr Asp Lys Ser Leu  Phe Tyr Arg Leu Leu  Ser Arg Glu 
    2645                 2650                 2655             


Leu Glu  Asn Cys Phe Gln Ile  Gly Ile Asp Gly Cys  Gly Lys Lys 
    2660                 2665                 2670             


Thr Cys  Ala Thr Leu Ala Cys  Tyr Leu Thr Asp Asn  Lys Leu Tyr 
    2675                 2680                 2685             


Arg Val  Pro Ile Ser His Lys  Cys Ala Tyr Ile Glu  Phe Lys Glu 
    2690                 2695                 2700             


Val Phe  Lys Lys Val Phe Ile  His Ala Gly Leu Lys  Gly Lys Pro 
    2705                 2710                 2715             


Thr Val  Leu Met Val Pro Asn  Leu Asn Ile Glu Gln  Asp Ser Phe 
    2720                 2725                 2730             


Leu Glu  Asp Leu Asn Tyr Ile  Ile Ser Ser Gly Arg  Ile Pro Asp 
    2735                 2740                 2745             


Leu Phe  Glu Asn Val Glu Leu  Asp Ser Ile Ala Met  Lys Ile Arg 
    2750                 2755                 2760             


Tyr Leu  Thr Glu Gln Ser Gly  His Met Asp Asn Arg  Gln Ser Leu 
    2765                 2770                 2775             


Leu Ser  Phe Phe Gln Lys Arg  Ile Tyr Lys Asn Leu  His Ile Phe 
    2780                 2785                 2790             


Val Ile  Met Ser Pro Glu Gly  Pro Ser Phe Arg Gln  Asn Cys Arg 
    2795                 2800                 2805             


Val Tyr  Pro Ser Met Ile Ser  Ser Cys Thr Ile Asp  Trp Tyr Glu 
    2810                 2815                 2820             


Arg Trp  Pro Glu Glu Ala Leu  Leu Ile Val Ala Asn  Ser Phe Leu 
    2825                 2830                 2835             


Lys Glu  Lys Val Asn Phe Glu  Asn Arg Glu Asn Leu  Lys Glu Lys 
    2840                 2845                 2850             


Leu Ala  Pro Thr Cys Val Gln  Ile His Lys Ser Met  Lys Asp Leu 
    2855                 2860                 2865             


Asn Arg  Lys Tyr Phe Glu Glu  Thr Gly Arg Phe Tyr  Tyr Thr Thr 
    2870                 2875                 2880             


Pro Asn  Ser Tyr Leu Gln Phe  Met Glu Thr Phe Ala  His Ile Leu 
    2885                 2890                 2895             


Arg Ala  Arg Glu Glu Glu Met  Gln Thr Lys Arg Asp  Arg Phe His 
    2900                 2905                 2910             


Met Gly  Leu Ser Thr Ile Leu  Glu Ala Thr Thr Leu  Val Thr Glu 
    2915                 2920                 2925             


Met Gln  Glu Glu Leu Leu Ile  Leu Gly Pro Gln Val  Glu Gln Lys 
    2930                 2935                 2940             


Thr Lys  Glu Thr Glu Thr Leu  Met Glu Lys Leu Arg  Lys Asp Ser 
    2945                 2950                 2955             


Gln Val  Val Glu Lys Val Gln  Met Leu Val Lys Gln  Asp Glu Glu 
    2960                 2965                 2970             


Ile Val  Ala Glu Glu Val Arg  Ile Val Glu Asp Tyr  Ala Gln Lys 
    2975                 2980                 2985             


Thr Ala  Asn Glu Leu Lys Ser  Val Leu Pro Ala Phe  Asp Lys Ala 
    2990                 2995                 3000             


Ile Val  Ala Leu Asn Ala Leu  Asp Lys Ala Asp Val  Ala Glu Leu 
    3005                 3010                 3015             


Arg Val  Tyr Thr Arg Pro Pro  Phe Leu Val Leu Thr  Val Met Asn 
    3020                 3025                 3030             


Ala Val  Cys Ile Leu Leu Gln  Lys Lys Pro Asn Trp  Ala Thr Ala 
    3035                 3040                 3045             


Lys Leu  Leu Leu Ser Glu Thr  Gly Phe Leu Lys Lys  Leu Ile Asn 
    3050                 3055                 3060             


Leu Asp  Lys Asp Ser Ile Pro  Asp Lys Val Phe Val  Lys Leu Lys 
    3065                 3070                 3075             


Lys Ile  Val Thr Leu Pro Asp  Phe Asn Pro His Lys  Ile Ser Leu 
    3080                 3085                 3090             


Val Ser  Val Ala Cys Cys Ser  Leu Cys Gln Trp Val  Ile Ala Leu 
    3095                 3100                 3105             


Asn Asn  Tyr His Glu Val Gln  Lys Val Val Gly Pro  Lys Gln Ile 
    3110                 3115                 3120             


Gln Val  Ala Glu Ala Gln Asn  Val Leu Lys Ile Ala  Arg Gln Arg 
    3125                 3130                 3135             


Leu Ala  Glu Lys Gln Arg Gly  Leu Gln Leu Val Glu  Glu His Leu 
    3140                 3145                 3150             


Leu Phe  Leu Gln Ala Ala Tyr  Lys Asp Thr Val Ala  Glu Lys Gln 
    3155                 3160                 3165             


Leu Leu  Ala Asn Arg Lys Thr  Met Ala Ser Arg Arg  Phe Gln Cys 
    3170                 3175                 3180             


Ala Ser  Val Leu Leu Thr Val  Leu Glu Asp Glu Lys  Thr Arg Trp 
    3185                 3190                 3195             


Gln Glu  Thr Ile Asn Gln Ile  Asp Asn Lys Leu Glu  Gly Ile Leu 
    3200                 3205                 3210             


Gly Asp  Ile Leu Leu Ser Ala  Ala Cys Ile Val Tyr  Ser Gly Ile 
    3215                 3220                 3225             


Leu Thr  Pro Glu Phe Arg Gln  Leu Ile Val Asn Lys  Trp Glu Thr 
    3230                 3235                 3240             


Phe Cys  Ile Glu Asn Gly Ile  Ser Leu Ser Ser Lys  Phe Ser Leu 
    3245                 3250                 3255             


Ile Lys  Val Met Ala Gln Lys  Tyr Glu Ile Ser Arg  Trp His Asn 
    3260                 3265                 3270             


Gln Gly  Leu Pro His Gly Gln  Tyr Ser Val Glu Asn  Ala Ile Leu 
    3275                 3280                 3285             


Ile Lys  Asn Gly Gln Gln Trp  Pro Leu Leu Ile Asp  Pro His Arg 
    3290                 3295                 3300             


Gln Ala  His Lys Trp Ile Arg  Gln Met Glu Gly Ser  Arg Leu Gln 
    3305                 3310                 3315             


Lys Leu  Ser Ile Glu Asp Ser  Asn Tyr Thr Lys Lys  Ile Glu Asn 
    3320                 3325                 3330             


Ala Met  Lys Thr Gly Gly Ser  Val Leu Leu Gln Asn  Leu Leu Glu 
    3335                 3340                 3345             


Thr Leu  Ala Pro Gly Leu Lys  Ala Ile Leu Lys Lys  Asp Ile Tyr 
    3350                 3355                 3360             


Gln Lys  Lys Gly His Tyr Phe  Ile Arg Val Gly Asp  Ala Glu Phe 
    3365                 3370                 3375             


Glu Tyr  Asn Ser Asn Phe Arg  Leu Tyr Leu Ser Thr  Glu Ile Asp 
    3380                 3385                 3390             


Asn Pro  His Phe Leu Pro Ser  Val Tyr Asn Phe Val  Thr Met Ile 
    3395                 3400                 3405             


Asn Phe  Thr Val Thr Phe Gln  Gly Leu Gln Asp Gln  Leu Leu Ser 
    3410                 3415                 3420             


Thr Val  Val Thr His Glu Val  Pro His Leu Glu Asp  Gln Arg Ser 
    3425                 3430                 3435             


Lys Leu  Leu Glu Ser Ile Ser  Leu Asp Ala Ile Thr  Leu Glu Glu 
    3440                 3445                 3450             


Leu Glu  Glu Lys Thr Leu Asn  Leu Leu Gln Lys Ala  Leu Gly Ser 
    3455                 3460                 3465             


Ile Leu  Asp Asp Asp Lys Ile  Val Asp Thr Leu Arg  Lys Ser Lys 
    3470                 3475                 3480             


Met Thr  Ser Asn Glu Ile Ser  Lys Arg Ile Glu Ala  Thr Lys Lys 
    3485                 3490                 3495             


Ala Glu  Ser Glu Ile Gln Ala  Ile Arg Lys Asn Tyr  Leu Pro Ile 
    3500                 3505                 3510             


Ala Thr  Arg Gly Ala Leu Leu  Tyr Phe Leu Val Ala  Asp Leu Thr 
    3515                 3520                 3525             


Gln Ile  Asn Tyr Met Tyr Gln  Phe Ser Leu Asp Trp  Phe His Gln 
    3530                 3535                 3540             


Val Phe  Val Ser Ser Val Val  Ser Lys Ser Lys Glu  Gln Glu His 
    3545                 3550                 3555             


Ser Phe  Lys Arg Glu Lys Val  Ser Pro Lys Glu Val  His Glu Phe 
    3560                 3565                 3570             


Ile Ser  Ile Ser Lys Glu Pro  Asn Leu Glu Asn Glu  Lys Asn Leu 
    3575                 3580                 3585             


Leu Asp  Lys His Ile Lys Ser  Ala Ile Asp Met Leu  Thr Lys Ser 
    3590                 3595                 3600             


Ile Phe  Lys Val Val Ser Ser  Ala Leu Phe Asn Glu  Asp Lys Leu 
    3605                 3610                 3615             


Cys Phe  Ser Phe Arg Leu Cys  Thr Val Ile Met Gln  Asn Asn Ala 
    3620                 3625                 3630             


Asn Gly  Asn Leu Ile Gln Asp  Asp Ile Gly Phe Leu  Pro Glu Glu 
    3635                 3640                 3645             


Glu Trp  Asn Ile Phe Leu Tyr  Ser Gly Ile Leu Ile  Asn Ile Lys 
    3650                 3655                 3660             


Ser Ala  Leu Ser Gln Ser Arg  Leu Thr Ser Thr Phe  Glu Ile Gly 
    3665                 3670                 3675             


Glu Ser  Gln His Leu Gln Trp  Leu Ser Asp Ser Arg  Trp Arg Gln 
    3680                 3685                 3690             


Cys Gln  Tyr Val Ser Thr His  Leu Glu Pro Phe Ser  Leu Leu Cys 
    3695                 3700                 3705             


Lys Ser  Leu Leu Ser Asn Val  Ser Gln Trp Asp Thr  Phe Lys Asn 
    3710                 3715                 3720             


Ser Lys  Ala Val Tyr Ser Leu  Ile Ser Thr Pro Phe  Ser Ser Glu 
    3725                 3730                 3735             


Asn Ala  Ser Leu Glu Glu Asn  Thr Lys Pro Pro Glu  Glu Thr Glu 
    3740                 3745                 3750             


Leu Leu  Asn Glu Asn Lys Glu  Thr Cys Asn Pro Ile  Asn Phe Pro 
    3755                 3760                 3765             


Trp Glu  Lys Leu Thr Ser Phe  Gln Arg Leu Ile Leu  Val Lys Val 
    3770                 3775                 3780             


Leu Arg  Pro Glu Ser Leu Asn  Asn Ser Val Arg Lys  Phe Ile Thr 
    3785                 3790                 3795             


Glu Lys  Met Gly Asn Lys Tyr  Leu Gln Arg Thr Gly  Val Asn Leu 
    3800                 3805                 3810             


Lys Asp  Ala Tyr Lys Gly Ser  Asn Ala Arg Thr Pro  Leu Ile Leu 
    3815                 3820                 3825             


Ile Gln  Thr His Gly Ile Asp  Leu Thr Asn Ile Leu  Leu Arg Phe 
    3830                 3835                 3840             


Ala Gln  Glu Leu Lys Gly Thr  Thr His His Val Thr  Ile Ile Ser 
    3845                 3850                 3855             


Leu Gly  Arg Asp Gln Ala Ala  Lys Ala Glu Asp Leu  Ile Leu Lys 
    3860                 3865                 3870             


Ala Leu  Thr Lys Thr Gln Gln  Trp Val Phe Leu Gln  Asn Cys His 
    3875                 3880                 3885             


Leu Ala  Thr Ser Phe Met Pro  Arg Leu Cys Thr Ile  Val Glu Ser 
    3890                 3895                 3900             


Phe Asn  Ser Pro Asn Val Thr  Ile Asp Pro Glu Phe  Arg Leu Trp 
    3905                 3910                 3915             


Leu Ser  Ser Lys Ser Tyr Ser  Ser Phe Pro Ile Pro  Val Leu Lys 
    3920                 3925                 3930             


Lys Gly  Leu Lys Ile Ala Val  Glu Ser Pro Gln Gly  Leu Lys Ser 
    3935                 3940                 3945             


Asn Leu  Leu Gln Thr Phe Gly  Cys Thr Gly Ser Gly  Glu Val Thr 
    3950                 3955                 3960             


Glu Glu  Ile Phe Glu Asn Pro  Asp Cys Gly Gln Trp  Trp Lys Lys 
    3965                 3970                 3975             


Leu Leu  Phe Ser Leu Cys Phe  Phe Asn Ala Val Ile  Asn Glu Arg 
    3980                 3985                 3990             


Lys Asn  Tyr Gly Ile Leu Gly  Trp Asn Ile Ala Tyr  Lys Phe Asn 
    3995                 4000                 4005             


Ser Ser  Asp Leu Gly Val Ala  Ile Lys Val Leu Glu  Asn Ser Leu 
    4010                 4015                 4020             


Arg Gly  Gln Pro Ser Ile Ser  Trp Gln Ala Leu Arg  Tyr Leu Ile 
    4025                 4030                 4035             


Gly Glu  Val Ile Tyr Gly Gly  Arg Val Ile Asp Asn  Trp Asp Lys 
    4040                 4045                 4050             


Arg Cys  Leu Lys Thr Leu Leu  Tyr Lys Phe Cys Asn  Pro Glu Val 
    4055                 4060                 4065             


Leu Lys  Asp Asp Phe Ser Phe  Ser Arg Ser Ala Ser  Ile Lys Asp 
    4070                 4075                 4080             


Tyr Ile  His Ile Ile Gln Ser  Leu Pro Asp Asp Asp  Leu Pro Glu 
    4085                 4090                 4095             


Val Leu  Gly Ile His Pro Glu  Ala Ile Arg Ser Cys  Trp Glu Thr 
    4100                 4105                 4110             


Gln Gly  Glu Lys Phe Ile Glu  Asn Leu Ile Ala Met  Gln Pro Lys 
    4115                 4120                 4125             


Thr Thr  Thr Ala Asn Leu Met  Ile Arg Pro Glu Gln  Ser Lys Asp 
    4130                 4135                 4140             


Glu Leu  Val Met Glu Ile Leu  Ser Asp Leu Leu Lys  Arg Leu Pro 
    4145                 4150                 4155             


Leu Thr  Val Glu Lys Glu Glu  Ile Ala Val Gly Thr  Pro Ser Thr 
    4160                 4165                 4170             


Leu Lys  Ser Met Met Ser Ser  Ser Ile Trp Glu Ser  Leu Ser Lys 
    4175                 4180                 4185             


Asn Leu  Lys Asp His Asp Pro  Leu Ile His Cys Val  Leu Leu Thr 
    4190                 4195                 4200             


Phe Leu  Lys Gln Glu Ile Lys  Arg Phe Asp Lys Leu  Leu Phe Val 
    4205                 4210                 4215             


Ile His  Lys Ser Leu Lys Asp  Leu Gln Leu Ala Ile  Lys Gly Glu 
    4220                 4225                 4230             


Ile Ile  Leu Thr Gln Glu Leu  Glu Glu Ile Phe Asn  Ser Phe Leu 
    4235                 4240                 4245             


Asn Met  Arg Val Pro Thr Leu  Trp Gln Lys His Ala  Tyr Arg Ser 
    4250                 4255                 4260             


Cys Lys  Pro Leu Ser Ser Trp  Ile Asp Asp Leu Ile  Gln Arg Leu 
    4265                 4270                 4275             


Asn Phe  Phe Asn Thr Trp Ala  Lys Val Ala Tyr Thr  Ala Ile Gln 
    4280                 4285                 4290             


Arg Arg  Tyr Met Arg Phe Val  Thr Val Trp Lys Gln  Ser Ile Pro 
    4295                 4300                 4305             


Ser Thr  Ser Gln Lys Cys Lys  His Pro Glu Asp Ser  Glu Asn Asn 
    4310                 4315                 4320             


Phe Phe  Glu Gly Phe Pro Ser  Arg Tyr Trp Leu Pro  Ala Phe Phe 
    4325                 4330                 4335             


Phe Pro  Gln Ala Phe Leu Ala  Ala Val Leu Gln Asp  Tyr Gly Arg 
    4340                 4345                 4350             


Ser Arg  Gly Ile Ala Val Asp  Ala Leu Thr Phe Thr  His His Val 
    4355                 4360                 4365             


Ile Ser  Asn Thr Thr Asp Lys  Asp Glu Lys Phe Ser  Val Phe Met 
    4370                 4375                 4380             


Pro Lys  Lys Leu Asn Ile Val  Arg Arg Ala Phe Lys  Gly Ser Ala 
    4385                 4390                 4395             


Ser Ser  His Thr Gly Val Tyr  Ile Phe Gly Leu Phe  Ile Glu Gly 
    4400                 4405                 4410             


Ala Arg  Trp Asn Arg Glu Gln  Lys Ile Leu Glu Asp  Ser Leu Pro 
    4415                 4420                 4425             


Leu Glu  Met Cys Cys Asp Phe  Pro Asp Ile Tyr Phe  Leu Pro Thr 
    4430                 4435                 4440             


Lys Ile  Ser Thr Lys Thr Pro  Asn Ala Ser Asn Gln  Thr Asp Ser 
    4445                 4450                 4455             


Glu Leu  Tyr Ala Phe Glu Cys  Pro Val Tyr Gln Thr  Pro Glu Arg 
    4460                 4465                 4470             


Ser Arg  Ile Leu Ala Thr Thr  Gly Leu Pro Thr Asn  Phe Leu Thr 
    4475                 4480                 4485             


Ser Val  Tyr Leu Ser Thr Lys  Lys Pro Pro Ser His  Trp Ile Thr 
    4490                 4495                 4500             


Met Arg  Val Ala Leu Leu Cys  Glu Lys Asn Glu Lys  
    4505                 4510                 4515 


<210>  4353
<211>  3507
<212>  PRT
<213>  Homo Sapiens

<400>  4353

Met Gly Arg Arg Ser Gln Trp Ile Trp Ala Met Arg Cys Gln Met Leu 
1               5                   10                  15      


Val Pro Val Leu Ser Leu His Ile Gly Leu Ala Arg Ala Leu Gly Cys 
            20                  25                  30          


Gly Cys Ile Ala Ser Lys Ile Glu Cys Leu Ile Arg Cys Asn Ala Pro 
        35                  40                  45              


Phe Pro Leu Leu Asp Ala Val Gly Ser Val Ala Ser Gln Glu Leu Gln 
    50                  55                  60                  


Ser Leu Thr Gly Thr Val Gly Val Thr Ser Gly Ala Ala Ala Tyr Pro 
65                  70                  75                  80  


Arg Trp Asn Leu Ala Arg Ala Arg Ala Pro Pro His Leu Pro Gly Thr 
                85                  90                  95      


Gln Asp Pro Leu Arg Arg Val Arg Asp Pro Thr Pro Ile Val Ala Ser 
            100                 105                 110         


Ser Pro Gly Arg Arg Arg Gly Ser Trp Ser Gly Gly Tyr Gly Gln Glu 
        115                 120                 125             


Ala Ser Glu Pro Gly Val Val Gly Leu Cys Cys Ala Val Leu Pro Ile 
    130                 135                 140                 


His Pro Ser Leu Ala Leu Ala Gly Val Gly Gly Pro Asp Leu Arg Arg 
145                 150                 155                 160 


Phe Gln Glu Gly Pro Gln Arg Pro Ser Asp His Gly Ala Ala Glu Lys 
                165                 170                 175     


His Met Glu Thr Phe Ile Pro Ile Asp Leu Thr Thr Glu Asn Gln Glu 
            180                 185                 190         


Met Asp Lys Glu Glu Thr Lys Thr Lys Pro Arg Leu Leu Arg Tyr Glu 
        195                 200                 205             


Glu Lys Lys Tyr Glu Asp Val Lys Pro Leu Glu Thr Gln Pro Ala Glu 
    210                 215                 220                 


Ile Ala Glu Lys Glu Thr Leu Glu Tyr Lys Thr Val Arg Thr Phe Ser 
225                 230                 235                 240 


Glu Ser Leu Lys Ser Glu Lys Thr Glu Glu Pro Lys Asp Asp Asp Val 
                245                 250                 255     


Ile Arg Asn Ile Ile Arg Leu Arg Glu Lys Leu Gly Trp Gln Thr Ile 
            260                 265                 270         


Leu Pro Gln His Ser Leu Lys Tyr Gly Ser Ser Lys Ile Ala Ile Gln 
        275                 280                 285             


Lys Ile Thr Leu Lys Lys Pro Leu Glu Asp Asp Gly Glu Phe Val Tyr 
    290                 295                 300                 


Cys Leu Pro Arg Lys Ser Pro Lys Ser Leu Tyr Asn Pro Tyr Asp Leu 
305                 310                 315                 320 


Gln Val Val Ser Ala His Thr Ala Lys His Cys Lys Glu Phe Trp Val 
                325                 330                 335     


Ile Thr Ala Ser Phe Ile Ser Lys Leu Asp Ser Ser Arg Thr Tyr Ser 
            340                 345                 350         


Leu Asp Glu Phe Cys Glu Glu Gln Leu Gln Gln Ala Thr Gln Ala Leu 
        355                 360                 365             


Lys Gln Leu Glu Asp Ile Arg Asn Lys Ala Ile Ser Glu Met Lys Ser 
    370                 375                 380                 


Thr Phe Leu Lys Val Ala Glu Lys Asn Glu Ile Lys Glu Tyr Phe Glu 
385                 390                 395                 400 


Ser Lys Leu Ser Glu Asp Asp Thr Thr His Phe Lys Leu Pro Lys Tyr 
                405                 410                 415     


Arg Arg Leu Leu Glu Thr Phe Phe Lys Phe Val Met Leu Val Asp Tyr 
            420                 425                 430         


Ile Phe Gln Glu Leu Ile Arg Gln Leu Met Asn Thr Ala Val Thr Leu 
        435                 440                 445             


Leu Leu Glu Leu Phe Asn Gly Ser Ala Gly Met Pro Phe Ser Val Glu 
    450                 455                 460                 


Lys Lys Asn Glu Asn Leu Ile Arg Thr Phe Lys Asp Asn Ser Phe Pro 
465                 470                 475                 480 


Thr Gly Lys Thr Thr Asn Asp Cys Glu Glu Leu Val Asp Asn Ser Lys 
                485                 490                 495     


Leu His Ala Ile Ser Val Gln Lys Ser Glu Val Lys Thr Asp Thr Asp 
            500                 505                 510         


Ile Asn Glu Ile Leu Asn Ser Val Glu Val Gly Lys Asp Leu Arg Lys 
        515                 520                 525             


Thr Tyr Ala Pro Ile Phe Glu Val Asn Leu Cys Leu Arg Ile Pro Ala 
    530                 535                 540                 


Glu Ser Asp Ser Ser Glu Asn Ser Lys Glu Asn Phe His Glu Ser Asp 
545                 550                 555                 560 


Gln Cys Pro Glu Glu Cys Val Met Phe Glu Asp Glu Met Ser Glu Asn 
                565                 570                 575     


Lys Asp Asn Cys Val Lys Lys His Ser Ser Glu Glu Leu Leu Pro Lys 
            580                 585                 590         


Ala Lys Lys Ser Lys Glu Ile Ser Tyr Asn Leu Glu Asp Ile Ile Ser 
        595                 600                 605             


Ala Thr Ile Thr Pro Leu Cys Gln Asp Pro Gln Leu Ser Ile Phe Ile 
    610                 615                 620                 


Asp Leu Val Ser Ile Met Asp Leu Pro Asn Lys Thr Gly Ser Ile Ile 
625                 630                 635                 640 


His Tyr Lys Glu Gln Thr Arg Trp Pro Asp Cys His Ile Leu Phe Glu 
                645                 650                 655     


Thr Asp Pro Ala Tyr Gln Asn Ile Ile Val Asn Leu Leu Thr Ile Ile 
            660                 665                 670         


Gly Asn Ser Met Gly Leu Val Asn Ala Tyr Ser His Lys Phe Ile Lys 
        675                 680                 685             


Tyr Cys Thr Met Thr Glu Lys Ala Lys Ile Met Ser Met Lys Ile Ser 
    690                 695                 700                 


Ser Met Gly Glu Leu Thr Ser Lys Glu Phe Glu Ala Ile Leu Asn Arg 
705                 710                 715                 720 


Phe Arg Asn Tyr Phe Arg His Ile Val Asn Met Ala Ile Glu Lys Arg 
                725                 730                 735     


Ile Gly Ile Phe Asn Val Val Val Glu Ser Ser Leu Gln Gln Leu Glu 
            740                 745                 750         


Cys Asp Pro Thr Glu Ile Glu Glu Phe Leu Glu His Phe Ile Phe Leu 
        755                 760                 765             


Asn Ala Ile Ser Ser Lys Ile Ser Lys Leu Glu Lys Glu Phe Leu Thr 
    770                 775                 780                 


Met Ser Gln Leu Tyr Ser Val Ala Lys His His Gln Ile His Ile Ser 
785                 790                 795                 800 


Glu Glu Gln Ile Ala Ile Phe Gln Val Leu Leu Leu Lys Phe Ser Gln 
                805                 810                 815     


Leu Lys Ser Ser Met Lys Leu Ser Lys Ile Asn Lys Asp Thr Ala Ile 
            820                 825                 830         


Thr Lys Phe Arg Asp Asn Leu Glu Ala Cys Ile Ser Gly Leu His Val 
        835                 840                 845             


Asp Val Gly Asn Leu Lys Ala Lys Ile Arg Thr Pro Leu Leu Leu Cys 
    850                 855                 860                 


Ala Gly Thr Gln Val Ser Thr Ala Met Glu Met Ile Gln Thr Leu Ser 
865                 870                 875                 880 


Gly Glu Ala Ala Ser Leu Thr Asn Lys Ala Lys Ala Tyr Ser His Tyr 
                885                 890                 895     


Gln Asp Cys Phe Ser Asp Ser Gln Ser His Met His Ser Val Asn Val 
            900                 905                 910         


Glu Glu Ile Thr Gln Ile Val Leu Ser Glu Ile Ser Asp Ile Glu Gly 
        915                 920                 925             


Asp Leu Thr Leu Arg Lys Lys Leu Trp Glu Ala Gln Glu Glu Trp Lys 
    930                 935                 940                 


Arg Ala Ser Trp Glu Trp Arg Asn Ser Ser Leu Gln Ser Ile Asp Val 
945                 950                 955                 960 


Glu Ser Val Gln Arg Asn Val Ser Lys Leu Met His Ile Ile Ser Val 
                965                 970                 975     


Leu Glu Lys Glu Ile Tyr Ser Ile Phe Ile Ile Pro Ser Ile Asp Asp 
            980                 985                 990         


Ile Ser Ala Gln Leu Glu Glu Ser  Gln Val Ile Leu Ala  Thr Ile Lys 
        995                 1000                 1005             


Gly Ser  Pro His Ile Gly Pro  Ile Lys Ser Gln Ile  Met Phe Tyr 
    1010                 1015                 1020             


Asn Asp  Cys Val Lys Ser Phe  Val Ser Ser Tyr Ser  Arg Glu Lys 
    1025                 1030                 1035             


Leu Glu  Lys Val His Ala Gly  Leu Met Cys His Leu  Glu Glu Val 
    1040                 1045                 1050             


Ala Asp  Leu Val Val Leu Asp  Thr Ser Asn Ser Arg  Thr Lys Ala 
    1055                 1060                 1065             


Ile Leu  Gly Ala Leu Leu Ile  Leu Tyr Val His Cys  Arg Asp Ile 
    1070                 1075                 1080             


Val Ile  Asn Leu Leu Leu Lys  Asn Ile Phe Asn Ala  Glu Asp Phe 
    1085                 1090                 1095             


Glu Trp  Thr Arg His Leu Gln  Tyr Lys Trp Asn Glu  Lys Gln Lys 
    1100                 1105                 1110             


Leu Cys  Tyr Val Ser Gln Gly  Asn Ala Ser Phe Thr  Tyr Gly Tyr 
    1115                 1120                 1125             


Glu Tyr  Leu Gly Cys Thr Ser  Arg Leu Val Ile Thr  Pro Leu Thr 
    1130                 1135                 1140             


Asp Arg  Cys Trp Leu Thr Leu  Met Glu Ala Leu His  Leu Asn Leu 
    1145                 1150                 1155             


Gly Gly  Cys Pro Ala Gly Pro  Ala Gly Thr Gly Lys  Thr Glu Thr 
    1160                 1165                 1170             


Val Lys  Asp Leu Ala Lys Cys  Ala Leu Phe Ala Phe  Lys Cys Asn 
    1175                 1180                 1185             


Thr Ala  Leu Ile Lys Leu Pro  Asn Ser Leu Ile Val  Leu Thr Cys 
    1190                 1195                 1200             


Phe Gly  Leu Glu Lys Thr Val  Leu Val Met Asn Thr  Val Met Ser 
    1205                 1210                 1215             


Phe Arg  Phe Val Leu Glu Gly  Lys Glu Ile Arg Ile  Asn Met Ser 
    1220                 1225                 1230             


Cys Ala  Val Phe Ile Thr Met  Asn Pro Arg Tyr Gly  Gly Gly Val 
    1235                 1240                 1245             


Glu Leu  Pro Asp Asn Leu Lys  Ser Leu Phe Arg Pro  Val Ala Met 
    1250                 1255                 1260             


Met Val  Pro His Tyr Gln Met  Ile Ala Glu Ile Ile  Leu Phe Ser 
    1265                 1270                 1275             


Phe Gly  Phe Lys Ser Ala Asn  Ser Leu Ser Gly Lys  Leu Thr Asn 
    1280                 1285                 1290             


Leu Tyr  Glu Leu Ala Arg Lys  Gln Leu Ser Gln Gln  Asp His Tyr 
    1295                 1300                 1305             


Asn Phe  Gly Leu Arg Ser Leu  Lys Ile Val Leu Ile  Met Ala Gly 
    1310                 1315                 1320             


Thr Lys  Lys Arg Glu Phe Lys  Cys Asp Thr Ser Asp  Ser Leu Ser 
    1325                 1330                 1335             


Glu Ala  Asp Glu Thr Leu Ile  Val Ile Glu Ala Ile  Arg Glu Ala 
    1340                 1345                 1350             


Ser Leu  Pro Lys Cys Pro Pro  Glu Asp Val Pro Leu  Phe Glu Asn 
    1355                 1360                 1365             


Ile Ile  Gly Asp Ile Phe Pro  Glu Val Thr Val Leu  Lys Val Asn 
    1370                 1375                 1380             


Gln Leu  Ala Leu Glu Lys Val  Ile Tyr Thr Ala Thr  Gln Gln Leu 
    1385                 1390                 1395             


Gly Leu  Gln Asn Trp Ser Ser  Gln Lys Glu Lys Ile  Ile Gln Phe 
    1400                 1405                 1410             


Tyr Asn  Gln Leu Gln Val Cys  Val Gly Val Met Leu  Val Gly Pro 
    1415                 1420                 1425             


Thr Gly  Gly Gly Lys Thr Thr  Val Arg Arg Ile Leu  Glu Lys Ala 
    1430                 1435                 1440             


Leu Thr  Leu Leu Pro Ile Ala  Asp Phe Leu Ser Val  Ala Glu Arg 
    1445                 1450                 1455             


Lys Ser  Ala Ser Lys Ile Ser  Glu Arg Lys Gly Lys  Val Asp Ile 
    1460                 1465                 1470             


Cys Val  Leu Asn Pro Lys Cys  Val Thr Leu Ser Glu  Leu Tyr Gly 
    1475                 1480                 1485             


Gln Leu  Asp Pro Asn Thr Met  Glu Trp Thr Asp Gly  Leu Leu Ser 
    1490                 1495                 1500             


Ala Thr  Ile Arg Ser Tyr Val  Tyr Phe Asn Thr Pro  Lys Asn Thr 
    1505                 1510                 1515             


Lys Lys  Asp Ile Asp Leu Arg  Leu Lys Ser Arg Ile  Ser Asp Leu 
    1520                 1525                 1530             


Ser Asn  Val Phe Lys Leu Asp  Ser Ser Asp Thr Thr  Glu Thr Asp 
    1535                 1540                 1545             


Asp Asn  Ile Phe Glu Glu Ile  Glu Lys Val Val Lys  Ile Pro Glu 
    1550                 1555                 1560             


Asn His  Asn Phe Asp Trp Gln  Trp Ile Ile Leu Asp  Gly Pro Val 
    1565                 1570                 1575             


Asp Thr  Phe Trp Val Glu Asn  Leu Asn Ser Val Leu  Asp Asp Thr 
    1580                 1585                 1590             


Arg Thr  Leu Cys Leu Ala Asn  Ser Glu Arg Ile Ala  Leu Thr Asn 
    1595                 1600                 1605             


Lys Ile  Arg Val Ile Phe Glu  Val Asp Asn Leu Ser  Gln Ala Ser 
    1610                 1615                 1620             


Pro Ala  Thr Val Ser Arg Cys  Ala Met Val Tyr Met  Asp Pro Val 
    1625                 1630                 1635             


Asp Leu  Gly Trp Glu Pro Tyr  Val Lys Ser Trp Leu  Leu Lys Thr 
    1640                 1645                 1650             


Ser Lys  Ile Ile Ser Gln Ser  Gly Val Asp Cys Leu  Glu Phe Met 
    1655                 1660                 1665             


Ile Lys  Asn Ser Val Thr Asp  Gly Leu Gln Phe Ile  Arg Asn Arg 
    1670                 1675                 1680             


Gln Lys  Phe Gln Pro Tyr Pro  Met Glu Asp Ile Thr  Val Val Ile 
    1685                 1690                 1695             


Thr Leu  Cys Arg Ile Leu Asp  Ala Phe Phe Asp Phe  Met Gly Lys 
    1700                 1705                 1710             


Asn Gly  Gly Phe Glu Gln Ser  Asp Asp Leu Asn Asp  Thr Ser Ser 
    1715                 1720                 1725             


Lys Glu  Ala Asn Ser Gln Arg  Glu Ser Val Thr Phe  Lys Asp Ile 
    1730                 1735                 1740             


Glu Lys  Arg Asp Glu Asn Thr  Trp Tyr Pro Glu Lys  Asn Pro Asp 
    1745                 1750                 1755             


Lys Leu  Thr Lys Ile Ile Gln  Lys Leu Phe Val Phe  Ala Phe Thr 
    1760                 1765                 1770             


Trp Ala  Phe Gly Gly Ala Leu  Asn Arg Glu Asp Glu  His Arg Glu 
    1775                 1780                 1785             


Asn Ile  Pro Phe Cys Pro Ser  Leu Glu Pro Asp Ser  Leu Ala Lys 
    1790                 1795                 1800             


Val Thr  Tyr Asp Phe Asp Lys  Leu Val His Glu Leu  Phe Gly Asn 
    1805                 1810                 1815             


Ser Ser  Gln Val Gly Ile Asn  Leu Pro Thr Gly Glu  Cys Ser Ile 
    1820                 1825                 1830             


Phe Gly  Tyr Phe Val Asp Ile  Glu Gln Cys Glu Phe  Ile Pro Trp 
    1835                 1840                 1845             


Ser Asp  Leu Val Pro Asn Asp  Gln Thr Leu Ile Gln  Arg Asp Asn 
    1850                 1855                 1860             


Pro Thr  Lys Lys Pro Glu Val  Arg Thr Asn Lys Lys  Leu Leu Lys 
    1865                 1870                 1875             


Asn Asn  Asp His Lys Gly Val  Val Val Ser Thr Ile  Asn Phe Ser 
    1880                 1885                 1890             


Thr Asn  Val Thr Ala Ala Lys  Thr Lys Glu Met Ile  Leu Lys Lys 
    1895                 1900                 1905             


Leu Ile  Arg Arg Thr Lys Asp  Thr Leu Gly Ala Pro  Lys Asn Asn 
    1910                 1915                 1920             


Arg Ile  Leu Ile Phe Ile Asp  Asp Met Asn Met Pro  Val Ser Asp 
    1925                 1930                 1935             


Met Tyr  Gly Ala Gln Pro Pro  Leu Glu Leu Ile Arg  Gln Leu Leu 
    1940                 1945                 1950             


Asp Leu  Gly Gly Val Tyr Asp  Thr Glu Lys Asn Thr  Trp Lys Asn 
    1955                 1960                 1965             


Ile Gln  Asp Leu Ser Ile Val  Ala Ala Cys Val Pro  Val Val Asn 
    1970                 1975                 1980             


Asp Ile  Ser Pro Arg Leu Leu  Lys His Phe Ser Met  Leu Val Leu 
    1985                 1990                 1995             


Pro His  Pro Ser Gln Asp Ile  Leu Cys Thr Ile Phe  Gln Ile Gly 
    2000                 2005                 2010             


Ile Asp  Gly Cys Gly Lys Lys  Thr Cys Ala Thr Leu  Ala Cys Tyr 
    2015                 2020                 2025             


Leu Thr  Asp Asn Lys Leu Tyr  Arg Val Pro Ile Ser  His Lys Cys 
    2030                 2035                 2040             


Ala Tyr  Ile Glu Phe Lys Glu  Val Phe Lys Lys Val  Phe Ile His 
    2045                 2050                 2055             


Ala Gly  Leu Lys Gly Lys Pro  Thr Val Leu Met Val  Pro Asn Leu 
    2060                 2065                 2070             


Asn Ile  Glu Gln Asp Ser Phe  Leu Glu Asp Leu Asn  Tyr Ile Ile 
    2075                 2080                 2085             


Ser Ser  Gly Arg Ile Pro Asp  Leu Phe Glu Asn Val  Glu Leu Asp 
    2090                 2095                 2100             


Ser Ile  Ala Met Lys Ile Arg  Tyr Leu Thr Glu Gln  Ser Gly His 
    2105                 2110                 2115             


Met Asp  Asn Arg Gln Ser Leu  Leu Ser Phe Phe Gln  Lys Arg Ile 
    2120                 2125                 2130             


Tyr Lys  Asn Leu His Ile Phe  Val Ile Met Ser Pro  Glu Gly Pro 
    2135                 2140                 2145             


Ser Phe  Arg Gln Asn Cys Arg  Val Tyr Pro Ser Met  Ile Ser Ser 
    2150                 2155                 2160             


Cys Thr  Ile Asp Trp Tyr Glu  Arg Trp Pro Glu Glu  Ala Leu Leu 
    2165                 2170                 2175             


Ile Val  Ala Asn Ser Phe Leu  Lys Glu Lys Val Asn  Phe Glu Asn 
    2180                 2185                 2190             


Arg Glu  Asn Leu Lys Glu Lys  Leu Ala Pro Thr Cys  Val Gln Ile 
    2195                 2200                 2205             


His Lys  Ser Met Lys Asp Leu  Asn Arg Lys Tyr Phe  Glu Glu Thr 
    2210                 2215                 2220             


Gly Arg  Phe Tyr Tyr Thr Thr  Pro Asn Ser Tyr Leu  Gln Phe Met 
    2225                 2230                 2235             


Glu Thr  Phe Ala His Ile Leu  Arg Ala Arg Glu Glu  Glu Met Gln 
    2240                 2245                 2250             


Thr Lys  Arg Asp Arg Phe His  Met Gly Leu Ser Thr  Ile Leu Glu 
    2255                 2260                 2265             


Ala Thr  Thr Leu Val Thr Glu  Met Gln Glu Glu Leu  Leu Ile Leu 
    2270                 2275                 2280             


Gly Pro  Gln Val Glu Gln Lys  Thr Lys Glu Thr Glu  Thr Leu Met 
    2285                 2290                 2295             


Glu Lys  Leu Arg Lys Asp Ser  Gln Val Val Glu Lys  Val Gln Met 
    2300                 2305                 2310             


Leu Val  Lys Gln Asp Glu Glu  Ile Val Ala Glu Glu  Val Arg Ile 
    2315                 2320                 2325             


Val Glu  Asp Tyr Ala Gln Lys  Thr Ala Asn Glu Leu  Lys Ser Val 
    2330                 2335                 2340             


Leu Pro  Ala Phe Asp Lys Ala  Ile Val Ala Leu Asn  Ala Leu Asp 
    2345                 2350                 2355             


Lys Ala  Asp Val Ala Glu Leu  Arg Val Tyr Thr Arg  Pro Pro Phe 
    2360                 2365                 2370             


Leu Val  Leu Thr Val Met Asn  Ala Val Cys Ile Leu  Leu Gln Lys 
    2375                 2380                 2385             


Lys Pro  Asn Trp Ala Thr Ala  Lys Leu Leu Leu Ser  Glu Thr Gly 
    2390                 2395                 2400             


Phe Leu  Lys Lys Leu Ile Asn  Leu Asp Lys Asp Ser  Ile Pro Asp 
    2405                 2410                 2415             


Lys Val  Phe Val Lys Leu Lys  Lys Ile Val Thr Leu  Pro Asp Phe 
    2420                 2425                 2430             


Asn Pro  His Lys Ile Ser Leu  Val Ser Val Ala Cys  Cys Ser Leu 
    2435                 2440                 2445             


Cys Gln  Trp Val Ile Ala Leu  Asn Asn Tyr His Glu  Val Gln Lys 
    2450                 2455                 2460             


Val Val  Gly Pro Lys Gln Ile  Gln Val Ala Glu Ala  Gln Asn Val 
    2465                 2470                 2475             


Leu Lys  Ile Ala Arg Gln Arg  Leu Ala Glu Lys Gln  Arg Gly Leu 
    2480                 2485                 2490             


Gln Leu  Ile Ser Arg Trp His  Asn Gln Gly Leu Pro  His Gly Gln 
    2495                 2500                 2505             


Tyr Ser  Val Glu Asn Ala Ile  Leu Ile Lys Asn Gly  Gln Gln Trp 
    2510                 2515                 2520             


Pro Leu  Leu Ile Asp Pro His  Arg Gln Ala His Lys  Trp Ile Arg 
    2525                 2530                 2535             


Gln Met  Glu Gly Ser Arg Leu  Gln Lys Leu Ser Ile  Glu Asp Ser 
    2540                 2545                 2550             


Asn Tyr  Thr Lys Lys Ile Glu  Asn Ala Met Lys Thr  Gly Gly Ser 
    2555                 2560                 2565             


Val Leu  Leu Gln Ser Cys Gln  Ala Ser Thr Trp Arg  Lys Lys Leu 
    2570                 2575                 2580             


Tyr Leu  Ser Thr Glu Ile Asp  Asn Pro His Phe Leu  Pro Ser Val 
    2585                 2590                 2595             


Tyr Asn  Phe Val Thr Met Ile  Asn Phe Thr Val Thr  Phe Gln Gly 
    2600                 2605                 2610             


Leu Gln  Asp Gln Leu Leu Ser  Thr Val Val Thr His  Glu Val Pro 
    2615                 2620                 2625             


His Leu  Glu Asp Gln Arg Ser  Lys Leu Leu Glu Ser  Ile Ser Leu 
    2630                 2635                 2640             


Asp Ala  Ile Thr Leu Glu Glu  Leu Glu Glu Lys Thr  Leu Asn Leu 
    2645                 2650                 2655             


Leu Gln  Lys Ala Leu Gly Ser  Ile Leu Asp Asp Asp  Lys Ile Val 
    2660                 2665                 2670             


Asp Thr  Leu Arg Lys Ser Lys  Met Thr Ser Asn Glu  Ile Ser Lys 
    2675                 2680                 2685             


Arg Ile  Glu Ala Thr Lys Lys  Ala Glu Ser Glu Ile  Gln Ala Ile 
    2690                 2695                 2700             


Arg Lys  Asn Tyr Leu Pro Ile  Ala Thr Arg Gly Ala  Leu Leu Tyr 
    2705                 2710                 2715             


Phe Leu  Val Ala Asp Leu Thr  Gln Ile Asn Tyr Met  Tyr Gln Phe 
    2720                 2725                 2730             


Ser Leu  Asp Trp Phe His Gln  Val Phe Val Ser Ser  Val Val Ser 
    2735                 2740                 2745             


Lys Ser  Lys Glu Gln Glu His  Ser Phe Lys Arg Glu  Lys Val Ser 
    2750                 2755                 2760             


Pro Lys  Glu Val His Glu Phe  Ile Ser Ile Ser Lys  Glu Pro Asn 
    2765                 2770                 2775             


Leu Glu  Asn Glu Lys Asn Leu  Leu Asp Lys His Ile  Lys Ser Ala 
    2780                 2785                 2790             


Ile Asp  Met Leu Thr Lys Ser  Ile Phe Lys Val Val  Ser Ser Ala 
    2795                 2800                 2805             


Leu Phe  Asn Glu Asp Lys Leu  Cys Phe Ser Phe Arg  Leu Cys Thr 
    2810                 2815                 2820             


Val Ile  Met Gln Asn Asn Ala  Asn Gly Asn Leu Ile  Gln Asp Asp 
    2825                 2830                 2835             


Ile Gly  Phe Leu Pro Glu Glu  Glu Trp Asn Ile Phe  Leu Tyr Ser 
    2840                 2845                 2850             


Gly Ile  Leu Ile Asn Ile Lys  Ser Ala Leu Ser Gln  Ser Arg Leu 
    2855                 2860                 2865             


Thr Ser  Thr Phe Glu Ile Gly  Glu Ser Gln His Leu  Gln Trp Leu 
    2870                 2875                 2880             


Ser Asp  Ser Arg Trp Arg Gln  Cys Gln Tyr Val Ser  Thr His Leu 
    2885                 2890                 2895             


Glu Pro  Phe Ser Leu Leu Cys  Lys Ser Leu Leu Ser  Asn Val Ser 
    2900                 2905                 2910             


Gln Trp  Asp Thr Phe Lys Asn  Ser Lys Ala Val Tyr  Ser Leu Ile 
    2915                 2920                 2925             


Ser Thr  Pro Phe Ser Ser Glu  Asn Ala Ser Leu Glu  Glu Asn Thr 
    2930                 2935                 2940             


Lys Pro  Pro Glu Glu Lys His  Thr Phe Cys Leu Leu  Leu Arg Ala 
    2945                 2950                 2955             


Ile Asn  His Thr Gly Thr Asp  Leu Gly Pro Val Gly  Arg Gly Gln 
    2960                 2965                 2970             


Trp Leu  Thr Ser Thr Ala Cys  Asp Arg His Thr Asp  Val Cys Ser 
    2975                 2980                 2985             


Phe Ser  Phe Ala Leu Asn Asp  Gly Val Pro Asp Val  Glu His Val 
    2990                 2995                 3000             


Gln Asp  Ile Phe Tyr Gly His  Cys Val Asp Lys Tyr  His Val Lys 
    3005                 3010                 3015             


Val Leu  Arg Pro Glu Ser Leu  Asn Asn Ser Val Arg  Lys Phe Ile 
    3020                 3025                 3030             


Thr Glu  Lys Met Gly Asn Lys  Tyr Leu Gln Arg Thr  Gly Val Asn 
    3035                 3040                 3045             


Leu Lys  Asp Ala Tyr Lys Gly  Ser Asn Ala Arg Thr  Pro Leu Ile 
    3050                 3055                 3060             


Leu Ile  Gln Thr His Gly Ser  Ala Ser Ile Lys Asp  Tyr Ile His 
    3065                 3070                 3075             


Ile Ile  Gln Ser Leu Pro Asp  Asp Asp Leu Pro Glu  Val Leu Gly 
    3080                 3085                 3090             


Ile His  Pro Glu Ala Ile Arg  Ser Cys Trp Glu Thr  Gln Gly Glu 
    3095                 3100                 3105             


Lys Phe  Ile Glu Asn Leu Ile  Ala Met Gln Pro Lys  Thr Thr Thr 
    3110                 3115                 3120             


Ala Asn  Leu Met Ile Arg Pro  Glu Gln Ser Lys Asp  Glu Leu Val 
    3125                 3130                 3135             


Met Glu  Ile Leu Ser Asp Leu  Leu Lys Arg Leu Pro  Leu Thr Val 
    3140                 3145                 3150             


Glu Lys  Glu Glu Ile Ala Val  Gly Thr Pro Ser Thr  Leu Lys Ser 
    3155                 3160                 3165             


Met Met  Ser Ser Ser Ile Trp  Glu Ser Leu Ser Lys  Asn Leu Lys 
    3170                 3175                 3180             


Asp His  Asp Pro Leu Ile His  Cys Val Leu Leu Thr  Phe Leu Lys 
    3185                 3190                 3195             


Gln Glu  Ile Lys Arg Phe Asp  Lys Leu Leu Phe Val  Ile His Lys 
    3200                 3205                 3210             


Ser Leu  Lys Asp Leu Gln Leu  Ala Ile Lys Gly Glu  Ile Ile Leu 
    3215                 3220                 3225             


Thr Gln  Glu Leu Glu Glu Ile  Phe Asn Ser Phe Leu  Asn Met Arg 
    3230                 3235                 3240             


Val Pro  Thr Leu Trp Gln Lys  His Ala Tyr Arg Ser  Cys Lys Pro 
    3245                 3250                 3255             


Leu Ser  Ser Trp Ile Asp Asp  Leu Ile Gln Arg Leu  Asn Phe Phe 
    3260                 3265                 3270             


Asn Thr  Trp Ala Lys Val Ala  Tyr Thr Ala Ile Gln  Arg Arg Tyr 
    3275                 3280                 3285             


Met Arg  Phe Val Thr Val Trp  Lys Gln Ser Ile Pro  Ser Thr Ser 
    3290                 3295                 3300             


Gln Lys  Cys Lys His Pro Glu  Asp Ser Glu Asn Asn  Phe Phe Glu 
    3305                 3310                 3315             


Gly Phe  Pro Ser Arg Tyr Trp  Leu Pro Ala Phe Phe  Phe Pro Gln 
    3320                 3325                 3330             


Ala Phe  Leu Ala Ala Val Leu  Gln Asp Tyr Gly Arg  Ser Arg Gly 
    3335                 3340                 3345             


Ile Ala  Val Asp Ala Leu Thr  Phe Thr His His Val  Ile Ser Asn 
    3350                 3355                 3360             


Thr Thr  Asp Lys Asp Glu Lys  Phe Ser Val Phe Met  Pro Lys Lys 
    3365                 3370                 3375             


Leu Asn  Ile Val Arg Arg Ala  Phe Lys Gly Ser Ala  Ser Ser His 
    3380                 3385                 3390             


Thr Gly  Val Tyr Ile Phe Gly  Leu Phe Ile Glu Gly  Ala Arg Trp 
    3395                 3400                 3405             


Asn Arg  Glu Gln Lys Ile Leu  Glu Asp Ser Leu Pro  Leu Glu Met 
    3410                 3415                 3420             


Cys Cys  Asp Phe Pro Asp Ile  Tyr Phe Leu Pro Thr  Lys Ile Ser 
    3425                 3430                 3435             


Thr Lys  Thr Pro Asn Ala Ser  Asn Gln Thr Asp Ser  Glu Leu Tyr 
    3440                 3445                 3450             


Ala Phe  Glu Cys Pro Val Tyr  Gln Thr Pro Glu Arg  Ser Arg Ile 
    3455                 3460                 3465             


Leu Ala  Thr Thr Gly Leu Pro  Thr Asn Phe Leu Thr  Ser Val Tyr 
    3470                 3475                 3480             


Leu Ser  Thr Lys Lys Pro Pro  Ser His Trp Ile Thr  Met Arg Val 
    3485                 3490                 3495             


Ala Leu  Leu Cys Glu Lys Asn  Glu Lys 
    3500                 3505         


<210>  4354
<211>  1481
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4354

Xaa Glu Leu Phe Gly Asn Ser Ser Gln Val Gly Ile Asn Leu Pro Thr 
1               5                   10                  15      


Gly Glu Cys Ser Ile Phe Gly Tyr Phe Val Asp Ile Glu Gln Cys Glu 
            20                  25                  30          


Phe Ile Pro Trp Ser Asp Leu Val Pro Asn Asp Gln Thr Leu Ile Gln 
        35                  40                  45              


Arg Gly Thr Ser Leu Leu Thr Asn Leu Gln Arg Ser Gly Gly Asn Phe 
    50                  55                  60                  


Leu Lys Ile Thr Glu Cys Gly Glu Cys Ile Asn Tyr Thr Ala Thr Arg 
65                  70                  75                  80  


Asp Thr Thr Cys Leu Ser Phe Leu Met Ser Leu Leu Leu Lys Asn Ser 
                85                  90                  95      


Cys Pro Val Leu Leu Thr Gly Glu Ser Gly Val Gly Lys Thr Ala Ala 
            100                 105                 110         


Ile Asn Gln Met Leu Glu Lys Leu Glu Gly Pro Gly Ala Phe Asp Ile 
        115                 120                 125             


Lys His Gly Ser Ile Leu Gly Asp Thr Leu Leu Tyr Ser Glu Ile Lys 
    130                 135                 140                 


Lys Ser Ser Ser Leu Lys Gln Asn Ile Thr Ile Leu Ile Pro Glu Thr 
145                 150                 155                 160 


His Lys Thr Ala Thr Gly Ser Ser Asp Asn Pro Thr Lys Lys Pro Glu 
                165                 170                 175     


Val Arg Thr Asn Lys Lys Leu Leu Lys Asn Asn Asp His Lys Gly Val 
            180                 185                 190         


Val Val Ser Thr Ile Asn Phe Ser Thr Asn Val Thr Ala Ala Lys Thr 
        195                 200                 205             


Lys Glu Met Ile Leu Lys Lys Leu Ile Arg Arg Thr Lys Asp Thr Leu 
    210                 215                 220                 


Gly Ala Pro Lys Asn Asn Arg Ile Leu Ile Phe Ile Asp Asp Met Asn 
225                 230                 235                 240 


Met Pro Val Ser Asp Met Tyr Gly Ala Gln Pro Pro Leu Glu Leu Ile 
                245                 250                 255     


Arg Gln Leu Leu Asp Leu Gly Gly Val Tyr Asp Thr Glu Lys Asn Thr 
            260                 265                 270         


Trp Lys Asn Ile Gln Asp Leu Ser Ile Val Ala Ala Cys Val Pro Val 
        275                 280                 285             


Val Asn Asp Ile Ser Pro Arg Leu Leu Lys His Phe Ser Met Leu Val 
    290                 295                 300                 


Leu Pro His Pro Ser Gln Asp Ile Leu Cys Thr Ile Phe Gln Leu Leu 
305                 310                 315                 320 


Leu Gly Leu Leu Gln Ala Asp Arg Thr Val Val Asn Ser Lys Glu Met 
                325                 330                 335     


Ala Ala Leu Leu Phe Val His Glu Ala Thr Arg Val Phe His Asp Arg 
            340                 345                 350         


Leu Ile Asp Phe Thr Asp Lys Ser Leu Phe Tyr Arg Leu Leu Ser Arg 
        355                 360                 365             


Glu Leu Glu Asn Cys Phe Gln Ile Gln Trp Thr Gln Glu Asn Leu Met 
    370                 375                 380                 


Asn His Ser Thr Val Phe Leu Asp Phe Leu Asp Ile Asn Lys Thr His 
385                 390                 395                 400 


Arg Lys Lys Ile Tyr Gln Asn Thr Ser Asp Tyr Asn Lys Leu Ala Ser 
                405                 410                 415     


Val Leu Asp Glu Phe Gln Met Lys Leu Gly Ser Ile Ser Leu Glu Leu 
            420                 425                 430         


Ser His Ser Met Val Phe Phe Lys Glu Ala Ile Glu His Ile Ile Arg 
        435                 440                 445             


Ala Thr Arg Val Leu Arg Gln Pro Gly Ser His Met Leu Leu Ile Gly 
    450                 455                 460                 


Ile Asp Gly Cys Gly Lys Lys Thr Cys Ala Thr Leu Ala Cys Tyr Leu 
465                 470                 475                 480 


Thr Asp Asn Lys Leu Tyr Arg Val Pro Ile Ser His Lys Cys Ala Tyr 
                485                 490                 495     


Ile Glu Phe Lys Glu Val Phe Lys Lys Val Phe Ile His Ala Gly Leu 
            500                 505                 510         


Lys Gly Lys Pro Thr Val Leu Met Val Pro Asn Leu Asn Ile Glu Gln 
        515                 520                 525             


Asp Ser Phe Leu Glu Asp Leu Asn Tyr Ile Ile Ser Ser Gly Arg Ile 
    530                 535                 540                 


Pro Asp Leu Phe Glu Asn Val Glu Leu Asp Ser Ile Ala Met Lys Ile 
545                 550                 555                 560 


Arg Tyr Leu Thr Glu Gln Ser Gly His Met Asp Asn Arg Gln Ser Leu 
                565                 570                 575     


Leu Ser Phe Phe Gln Lys Arg Ile Tyr Lys Asn Leu His Ile Phe Val 
            580                 585                 590         


Ile Met Ser Pro Glu Gly Pro Ser Phe Arg Gln Asn Cys Arg Val Tyr 
        595                 600                 605             


Pro Ser Met Ile Ser Ser Cys Thr Ile Asp Trp Tyr Glu Arg Trp Pro 
    610                 615                 620                 


Glu Glu Ala Leu Leu Ile Val Ala Asn Ser Phe Leu Lys Glu Lys Val 
625                 630                 635                 640 


Asn Phe Glu Asn Arg Glu Asn Leu Lys Glu Lys Leu Ala Pro Thr Cys 
                645                 650                 655     


Val Gln Ile His Lys Ser Met Lys Asp Leu Asn Arg Lys Tyr Phe Glu 
            660                 665                 670         


Glu Thr Gly Arg Phe Tyr Tyr Thr Thr Pro Asn Ser Tyr Leu Gln Phe 
        675                 680                 685             


Met Glu Thr Phe Ala His Ile Leu Arg Ala Arg Glu Glu Glu Met Gln 
    690                 695                 700                 


Thr Lys Arg Asp Arg Phe His Met Gly Leu Ser Thr Ile Leu Glu Ala 
705                 710                 715                 720 


Thr Thr Leu Val Thr Glu Met Gln Glu Glu Leu Leu Ile Leu Gly Pro 
                725                 730                 735     


Gln Val Glu Gln Lys Thr Lys Glu Thr Glu Thr Leu Met Glu Lys Leu 
            740                 745                 750         


Arg Lys Asp Ser Gln Val Val Glu Lys Val Gln Met Leu Val Lys Gln 
        755                 760                 765             


Asp Glu Glu Ile Val Ala Glu Glu Val Arg Ile Val Glu Asp Tyr Ala 
    770                 775                 780                 


Gln Lys Thr Ala Asn Glu Leu Lys Ser Val Leu Pro Ala Phe Asp Lys 
785                 790                 795                 800 


Ala Ile Val Ala Leu Asn Ala Leu Asp Lys Ala Asp Val Ala Glu Leu 
                805                 810                 815     


Arg Val Tyr Thr Arg Pro Pro Phe Leu Val Leu Thr Val Met Asn Ala 
            820                 825                 830         


Val Cys Ile Leu Leu Gln Lys Lys Pro Asn Trp Ala Thr Ala Lys Leu 
        835                 840                 845             


Leu Leu Ser Glu Thr Gly Phe Leu Lys Lys Leu Ile Asn Leu Asp Lys 
    850                 855                 860                 


Asp Ser Ile Pro Asp Lys Val Phe Val Lys Leu Lys Lys Ile Val Thr 
865                 870                 875                 880 


Leu Pro Asp Phe Asn Pro His Lys Ile Ser Leu Val Ser Val Ala Cys 
                885                 890                 895     


Cys Ser Leu Cys Gln Trp Val Ile Ala Leu Asn Asn Tyr His Glu Val 
            900                 905                 910         


Gln Lys Val Val Gly Pro Lys Gln Ile Gln Val Ala Glu Ala Gln Asn 
        915                 920                 925             


Val Leu Lys Ile Ala Arg Gln Arg Leu Ala Glu Lys Gln Arg Gly Leu 
    930                 935                 940                 


Gln Leu Val Glu Glu His Leu Leu Phe Leu Gln Ala Ala Tyr Lys Asp 
945                 950                 955                 960 


Thr Val Ala Glu Lys Gln Leu Leu Ala Asn Arg Lys Thr Met Ala Ser 
                965                 970                 975     


Arg Arg Phe Gln Cys Ala Ser Val Leu Leu Thr Val Leu Glu Asp Glu 
            980                 985                 990         


Lys Ile Ser Arg Trp His Asn Gln  Gly Leu Pro His Gly  Gln Tyr Ser 
        995                 1000                 1005             


Val Glu  Asn Ala Ile Leu Ile  Lys Asn Gly Gln Gln  Trp Pro Leu 
    1010                 1015                 1020             


Leu Ile  Asp Pro His Arg Gln  Ala His Lys Trp Ile  Arg Gln Met 
    1025                 1030                 1035             


Glu Gly  Ser Arg Leu Gln Lys  Leu Ser Ile Glu Asp  Ser Asn Tyr 
    1040                 1045                 1050             


Thr Lys  Lys Ile Glu Asn Ala  Met Lys Thr Gly Gly  Ser Val Leu 
    1055                 1060                 1065             


Leu Gln  Asn Leu Leu Glu Thr  Leu Ala Pro Gly Leu  Lys Ala Ile 
    1070                 1075                 1080             


Leu Lys  Lys Asp Ile Tyr Gln  Lys Lys Gly His Tyr  Phe Ile Arg 
    1085                 1090                 1095             


Val Gly  Asp Ala Glu Phe Glu  Tyr Asn Ser Asn Phe  Arg Leu Tyr 
    1100                 1105                 1110             


Leu Ser  Thr Glu Ile Asp Asn  Pro His Phe Leu Pro  Ser Val Tyr 
    1115                 1120                 1125             


Asn Phe  Val Thr Met Ile Asn  Phe Thr Val Thr Phe  Gln Gly Leu 
    1130                 1135                 1140             


Gln Asp  Gln Leu Leu Ser Thr  Val Val Thr His Glu  Val Pro His 
    1145                 1150                 1155             


Leu Glu  Asp Gln Arg Ser Lys  Leu Leu Glu Ser Ile  Ser Leu Asp 
    1160                 1165                 1170             


Ala Ile  Thr Leu Glu Glu Leu  Glu Glu Lys Thr Leu  Asn Leu Leu 
    1175                 1180                 1185             


Gln Lys  Ala Leu Gly Ser Ile  Leu Asp Asp Asp Lys  Ile Val Asp 
    1190                 1195                 1200             


Thr Leu  Arg Lys Ser Lys Met  Thr Ser Asn Glu Ile  Ser Lys Arg 
    1205                 1210                 1215             


Ile Glu  Ala Thr Lys Lys Ala  Glu Ser Glu Ile Gln  Ala Ile Arg 
    1220                 1225                 1230             


Lys Asn  Tyr Leu Pro Ile Ala  Thr Arg Gly Ala Leu  Leu Tyr Phe 
    1235                 1240                 1245             


Leu Val  Ala Asp Leu Thr Gln  Ile Asn Tyr Met Tyr  Gln Phe Ser 
    1250                 1255                 1260             


Leu Asp  Trp Phe His Gln Val  Phe Val Ser Ser Val  Val Ser Lys 
    1265                 1270                 1275             


Ser Lys  Glu Gln Glu His Ser  Phe Lys Arg Glu Lys  Val Ser Pro 
    1280                 1285                 1290             


Lys Glu  Val His Glu Phe Ile  Ser Ile Ser Lys Glu  Pro Asn Leu 
    1295                 1300                 1305             


Glu Asn  Glu Lys Asn Leu Leu  Asp Lys His Ile Lys  Ser Ala Ile 
    1310                 1315                 1320             


Asp Met  Leu Thr Lys Ser Ile  Phe Lys Val Val Ser  Ser Ala Leu 
    1325                 1330                 1335             


Phe Asn  Glu Asp Lys Leu Cys  Phe Ser Phe Arg Leu  Cys Thr Val 
    1340                 1345                 1350             


Ile Met  Gln Asn Asn Ala Asn  Gly Asn Leu Ile Gln  Asp Asp Ile 
    1355                 1360                 1365             


Gly Phe  Leu Pro Glu Glu Glu  Trp Asn Ile Phe Leu  Tyr Ser Gly 
    1370                 1375                 1380             


Ile Leu  Ile Asn Ile Lys Ser  Ala Leu Ser Gln Ser  Arg Leu Thr 
    1385                 1390                 1395             


Ser Thr  Phe Glu Ile Gly Glu  Ser Gln His Leu Gln  Trp Leu Ser 
    1400                 1405                 1410             


Asp Ser  Arg Trp Arg Gln Cys  Gln Tyr Val Ser Thr  His Leu Glu 
    1415                 1420                 1425             


Pro Phe  Ser Leu Leu Cys Lys  Ser Leu Leu Ser Asn  Val Ser Gln 
    1430                 1435                 1440             


Trp Asp  Thr Phe Lys Asn Ser  Lys Ala Val Tyr Ser  Leu Ile Ser 
    1445                 1450                 1455             


Thr Pro  Phe Ser Ser Glu Asn  Ala Ser Leu Glu Glu  Asn Thr Lys 
    1460                 1465                 1470             


Pro Pro  Glu Glu Ser Lys Ser  Ser 
    1475                 1480     


<210>  4355
<211>  1477
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4355

Xaa Glu Leu Phe Gly Asn Ser Ser Gln Val Gly Ile Asn Leu Pro Thr 
1               5                   10                  15      


Gly Glu Cys Ser Ile Phe Gly Tyr Phe Val Asp Ile Glu Gln Cys Glu 
            20                  25                  30          


Phe Ile Pro Trp Ser Asp Leu Val Pro Asn Asp Gln Thr Leu Ile Gln 
        35                  40                  45              


Arg Gly Thr Ser Leu Leu Thr Asn Leu Gln Arg Ser Gly Gly Asn Phe 
    50                  55                  60                  


Leu Lys Ile Thr Glu Cys Gly Glu Cys Ile Asn Tyr Thr Ala Thr Arg 
65                  70                  75                  80  


Asp Thr Thr Cys Leu Ser Phe Leu Met Ser Leu Leu Leu Lys Asn Ser 
                85                  90                  95      


Cys Pro Val Leu Leu Thr Gly Glu Ser Gly Val Gly Lys Thr Ala Ala 
            100                 105                 110         


Ile Asn Gln Met Leu Glu Lys Leu Glu Gly Pro Gly Ala Phe Asp Ile 
        115                 120                 125             


Lys His Gly Ser Ile Leu Gly Asp Thr Leu Leu Tyr Ser Glu Ile Lys 
    130                 135                 140                 


Lys Ser Ser Ser Leu Lys Gln Asn Ile Thr Ile Leu Ile Pro Glu Thr 
145                 150                 155                 160 


His Lys Thr Ala Thr Gly Ser Ser Asp Asn Pro Thr Lys Lys Pro Glu 
                165                 170                 175     


Val Arg Thr Asn Lys Lys Leu Leu Lys Asn Asn Asp His Lys Gly Val 
            180                 185                 190         


Val Val Ser Thr Ile Asn Phe Ser Thr Asn Val Thr Ala Ala Lys Thr 
        195                 200                 205             


Lys Glu Met Ile Leu Lys Lys Leu Ile Arg Arg Thr Lys Asp Thr Leu 
    210                 215                 220                 


Gly Ala Pro Lys Asn Asn Arg Ile Leu Ile Phe Ile Asp Asp Met Asn 
225                 230                 235                 240 


Met Pro Val Ser Asp Met Tyr Gly Ala Gln Pro Pro Leu Glu Leu Ile 
                245                 250                 255     


Arg Gln Leu Leu Asp Leu Gly Gly Val Tyr Asp Thr Glu Lys Asn Thr 
            260                 265                 270         


Trp Lys Asn Ile Gln Asp Leu Ser Ile Val Ala Ala Cys Val Pro Val 
        275                 280                 285             


Val Asn Asp Ile Ser Pro Arg Leu Leu Lys His Phe Ser Met Leu Val 
    290                 295                 300                 


Leu Pro His Pro Ser Gln Asp Ile Leu Cys Thr Ile Phe Gln Leu Leu 
305                 310                 315                 320 


Leu Gly Leu Leu Gln Ala Asp Arg Thr Val Val Asn Ser Lys Glu Met 
                325                 330                 335     


Ala Ala Leu Leu Phe Val His Glu Ala Thr Arg Val Phe His Asp Arg 
            340                 345                 350         


Leu Ile Asp Phe Thr Asp Lys Ser Leu Phe Tyr Arg Leu Leu Ser Arg 
        355                 360                 365             


Glu Leu Glu Asn Cys Phe Gln Ile Gln Trp Thr Gln Glu Asn Leu Met 
    370                 375                 380                 


Asn His Ser Thr Val Phe Leu Asp Phe Leu Asp Ile Asn Lys Thr His 
385                 390                 395                 400 


Arg Lys Lys Ile Tyr Gln Asn Thr Ser Asp Tyr Asn Lys Leu Ala Ser 
                405                 410                 415     


Val Leu Asp Glu Phe Gln Met Lys Leu Gly Ser Ile Ser Leu Glu Leu 
            420                 425                 430         


Ser His Ser Met Val Phe Phe Lys Glu Ala Ile Glu His Ile Ile Arg 
        435                 440                 445             


Ala Thr Arg Val Leu Arg Gln Pro Gly Ser His Met Leu Leu Ile Gly 
    450                 455                 460                 


Ile Asp Gly Cys Gly Lys Lys Thr Cys Ala Thr Leu Ala Cys Tyr Leu 
465                 470                 475                 480 


Thr Asp Asn Lys Leu Tyr Arg Val Pro Ile Ser His Lys Cys Ala Tyr 
                485                 490                 495     


Ile Glu Phe Lys Glu Val Phe Lys Lys Val Phe Ile His Ala Gly Leu 
            500                 505                 510         


Lys Gly Lys Pro Thr Val Leu Met Val Pro Asn Leu Asn Ile Glu Gln 
        515                 520                 525             


Asp Ser Phe Leu Glu Asp Leu Asn Tyr Ile Ile Ser Ser Gly Arg Ile 
    530                 535                 540                 


Pro Asp Leu Phe Glu Asn Val Glu Leu Asp Ser Ile Ala Met Lys Ile 
545                 550                 555                 560 


Arg Tyr Leu Thr Glu Gln Ser Gly His Met Asp Asn Arg Gln Ser Leu 
                565                 570                 575     


Leu Ser Phe Phe Gln Lys Arg Ile Tyr Lys Asn Leu His Ile Phe Val 
            580                 585                 590         


Ile Met Ser Pro Glu Gly Pro Ser Phe Arg Gln Asn Cys Arg Val Tyr 
        595                 600                 605             


Pro Ser Met Ile Ser Ser Cys Thr Ile Asp Trp Tyr Glu Arg Trp Pro 
    610                 615                 620                 


Glu Glu Ala Leu Leu Ile Val Ala Asn Ser Phe Leu Lys Glu Lys Val 
625                 630                 635                 640 


Asn Phe Glu Asn Arg Glu Asn Leu Lys Glu Lys Leu Ala Pro Thr Cys 
                645                 650                 655     


Val Gln Ile His Lys Ser Met Lys Asp Leu Asn Arg Lys Tyr Phe Glu 
            660                 665                 670         


Glu Thr Gly Arg Phe Tyr Tyr Thr Thr Pro Asn Ser Tyr Leu Gln Phe 
        675                 680                 685             


Met Glu Thr Phe Ala His Ile Leu Arg Ala Arg Glu Glu Glu Met Gln 
    690                 695                 700                 


Thr Lys Arg Asp Arg Phe His Met Gly Leu Ser Thr Ile Leu Glu Ala 
705                 710                 715                 720 


Thr Thr Leu Val Thr Glu Met Gln Glu Glu Leu Leu Ile Leu Gly Pro 
                725                 730                 735     


Gln Val Glu Gln Lys Thr Lys Glu Thr Glu Thr Leu Met Glu Lys Leu 
            740                 745                 750         


Arg Lys Asp Ser Gln Val Val Glu Lys Val Gln Met Leu Val Lys Gln 
        755                 760                 765             


Asp Glu Glu Ile Val Ala Glu Glu Val Arg Ile Val Glu Asp Tyr Ala 
    770                 775                 780                 


Gln Lys Thr Ala Asn Glu Leu Lys Ser Val Leu Pro Ala Phe Asp Lys 
785                 790                 795                 800 


Ala Ile Val Ala Leu Asn Ala Leu Asp Lys Ala Asp Val Ala Glu Leu 
                805                 810                 815     


Arg Val Tyr Thr Arg Pro Pro Phe Leu Val Leu Thr Val Met Asn Ala 
            820                 825                 830         


Val Cys Ile Leu Leu Gln Lys Lys Pro Asn Trp Ala Thr Ala Lys Leu 
        835                 840                 845             


Leu Leu Ser Glu Thr Gly Phe Leu Lys Lys Leu Ile Asn Leu Asp Lys 
    850                 855                 860                 


Asp Ser Ile Pro Asp Lys Val Phe Val Lys Leu Lys Lys Ile Val Thr 
865                 870                 875                 880 


Leu Pro Asp Phe Asn Pro His Lys Ile Ser Leu Val Ser Val Ala Cys 
                885                 890                 895     


Cys Ser Leu Cys Gln Trp Val Ile Ala Leu Asn Asn Tyr His Glu Val 
            900                 905                 910         


Gln Lys Val Val Gly Pro Lys Gln Ile Gln Val Ala Glu Ala Gln Asn 
        915                 920                 925             


Val Leu Lys Ile Ala Arg Gln Arg Leu Ala Glu Lys Gln Arg Gly Leu 
    930                 935                 940                 


Gln Leu Val Glu Glu His Leu Leu Phe Leu Gln Ala Ala Tyr Lys Asp 
945                 950                 955                 960 


Thr Val Ala Glu Lys Gln Leu Leu Ala Asn Arg Lys Thr Met Ala Ser 
                965                 970                 975     


Arg Arg Phe Gln Cys Ala Ser Val Leu Leu Thr Val Leu Glu Asp Glu 
            980                 985                 990         


Lys Ile Ser Arg Trp His Asn Gln  Gly Leu Pro His Gly  Gln Tyr Ser 
        995                 1000                 1005             


Val Glu  Asn Ala Ile Leu Ile  Lys Asn Gly Gln Gln  Trp Pro Leu 
    1010                 1015                 1020             


Leu Ile  Asp Pro His Arg Gln  Ala His Lys Trp Ile  Arg Gln Met 
    1025                 1030                 1035             


Glu Gly  Ser Arg Leu Gln Lys  Leu Ser Ile Glu Asp  Ser Asn Tyr 
    1040                 1045                 1050             


Thr Lys  Lys Ile Glu Asn Ala  Met Lys Thr Gly Gly  Ser Val Leu 
    1055                 1060                 1065             


Leu Gln  Asn Leu Leu Glu Thr  Leu Ala Pro Gly Leu  Lys Ala Ile 
    1070                 1075                 1080             


Leu Lys  Lys Asp Ile Tyr Gln  Lys Lys Gly His Tyr  Phe Ile Arg 
    1085                 1090                 1095             


Val Gly  Asp Ala Glu Phe Glu  Tyr Asn Ser Asn Phe  Arg Leu Tyr 
    1100                 1105                 1110             


Leu Ser  Thr Glu Ile Asp Asn  Pro His Phe Leu Pro  Ser Val Tyr 
    1115                 1120                 1125             


Asn Phe  Val Thr Met Ile Asn  Phe Thr Val Thr Phe  Gln Gly Leu 
    1130                 1135                 1140             


Gln Asp  Gln Leu Leu Ser Thr  Val Val Thr His Glu  Val Pro His 
    1145                 1150                 1155             


Leu Glu  Asp Gln Arg Ser Lys  Leu Leu Glu Ser Ile  Ser Leu Asp 
    1160                 1165                 1170             


Ala Ile  Thr Leu Glu Glu Leu  Glu Glu Lys Thr Leu  Asn Leu Leu 
    1175                 1180                 1185             


Gln Lys  Ala Leu Gly Ser Ile  Leu Asp Asp Asp Lys  Ile Val Asp 
    1190                 1195                 1200             


Thr Leu  Arg Lys Ser Lys Met  Thr Ser Asn Glu Ile  Ser Lys Arg 
    1205                 1210                 1215             


Ile Glu  Ala Thr Lys Lys Ala  Glu Ser Glu Ile Gln  Ala Ile Arg 
    1220                 1225                 1230             


Lys Asn  Tyr Leu Pro Ile Ala  Thr Arg Gly Ala Leu  Leu Tyr Phe 
    1235                 1240                 1245             


Leu Val  Ala Asp Leu Thr Gln  Ile Asn Tyr Met Tyr  Gln Phe Ser 
    1250                 1255                 1260             


Leu Asp  Trp Phe His Gln Val  Phe Val Ser Ser Val  Val Ser Lys 
    1265                 1270                 1275             


Ser Lys  Glu Gln Glu His Ser  Phe Lys Arg Glu Lys  Val Ser Pro 
    1280                 1285                 1290             


Lys Glu  Val His Glu Phe Ile  Ser Ile Ser Lys Glu  Pro Asn Leu 
    1295                 1300                 1305             


Glu Asn  Glu Lys Asn Leu Leu  Asp Lys His Ile Lys  Ser Ala Ile 
    1310                 1315                 1320             


Asp Met  Leu Thr Lys Ser Ile  Phe Lys Val Val Ser  Ser Ala Leu 
    1325                 1330                 1335             


Phe Asn  Glu Asp Lys Leu Cys  Phe Ser Phe Arg Leu  Cys Thr Val 
    1340                 1345                 1350             


Ile Met  Gln Asn Asn Ala Asn  Gly Asn Leu Ile Gln  Asp Asp Ile 
    1355                 1360                 1365             


Gly Phe  Leu Pro Glu Glu Glu  Trp Asn Ile Phe Leu  Tyr Ser Gly 
    1370                 1375                 1380             


Ile Leu  Ile Asn Ile Lys Ser  Ala Leu Ser Gln Ser  Arg Leu Thr 
    1385                 1390                 1395             


Ser Thr  Phe Glu Ile Gly Glu  Ser Gln His Leu Gln  Trp Leu Ser 
    1400                 1405                 1410             


Asp Ser  Arg Trp Arg Gln Cys  Gln Tyr Val Ser Thr  His Leu Glu 
    1415                 1420                 1425             


Pro Phe  Ser Leu Leu Cys Lys  Ser Leu Leu Ser Asn  Val Ser Gln 
    1430                 1435                 1440             


Trp Asp  Thr Phe Lys Asn Ser  Lys Ala Val Tyr Ser  Leu Ile Ser 
    1445                 1450                 1455             


Thr Pro  Phe Ser Ser Glu Asn  Ala Ser Leu Glu Glu  Asn Thr Lys 
    1460                 1465                 1470             


Pro Pro  Glu Glu 
    1475         


<210>  4356
<211>  126
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4356

Xaa Leu Glu Tyr Lys Thr Val Arg Thr Phe Ser Glu Ser Leu Lys Ser 
1               5                   10                  15      


Glu Lys Thr Glu Glu Pro Lys Asp Asp Asp Val Ile Arg Asn Ile Ile 
            20                  25                  30          


Arg Leu Arg Glu Lys Leu Gly Trp Gln Thr Ile Leu Pro Gln His Ser 
        35                  40                  45              


Leu Lys Tyr Gly Ser Ser Lys Ile Ala Ile Gln Lys Ile Thr Leu Lys 
    50                  55                  60                  


Lys Pro Leu Glu Asp Asp Gly Glu Phe Val Tyr Cys Leu Pro Arg Lys 
65                  70                  75                  80  


Ser Pro Lys Ser Leu Tyr Asn Pro Tyr Asp Leu Gln Val Val Ser Ala 
                85                  90                  95      


His Thr Ala Lys His Cys Lys Glu Phe Trp Val Ile Thr Ala Ser Phe 
            100                 105                 110         


Ile Ser Lys Arg Tyr Leu Val Ile Cys Gly Ala Val Tyr Ile 
        115                 120                 125     


<210>  4357
<211>  204
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4357

Xaa Met Leu Ile Ser Ala Glu Gly Glu Gly Leu Val Leu Pro Lys Lys 
1               5                   10                  15      


Ile Arg Val Arg Ser Ala Val Glu Gln Trp Leu Val Asn Val Glu Lys 
            20                  25                  30          


Ser Met Phe Asp Val Leu Lys Lys Phe Leu Ser Gln Gly Ile Glu Asp 
        35                  40                  45              


Trp Asn Cys Gln Met Phe Ser Gln Trp Val Leu Ser His Pro Gly Gln 
    50                  55                  60                  


Val Val Leu Thr Val Ser Gln Ile Met Phe Tyr Asn Asp Cys Val Lys 
65                  70                  75                  80  


Ser Phe Val Ser Ser Tyr Ser Arg Glu Lys Leu Glu Lys Val His Ala 
                85                  90                  95      


Gly Leu Met Cys His Leu Glu Glu Val Ala Asp Leu Val Val Leu Asp 
            100                 105                 110         


Thr Ser Asn Ser Arg Thr Lys Ala Ile Leu Gly Ala Leu Leu Ile Leu 
        115                 120                 125             


Tyr Val His Cys Arg Asp Ile Val Ile Asn Leu Leu Leu Lys Asn Ile 
    130                 135                 140                 


Phe Asn Ala Glu Asp Phe Glu Trp Thr Arg His Leu Gln Tyr Lys Trp 
145                 150                 155                 160 


Asn Glu Lys Gln Lys Leu Cys Tyr Val Ser Gln Gly Asn Ala Ser Phe 
                165                 170                 175     


Thr Tyr Gly Tyr Glu Tyr Leu Gly Cys Thr Ser Arg Leu Val Ile Thr 
            180                 185                 190         


Pro Leu Thr Asp Arg Cys Trp Leu Thr Leu Met Glu 
        195                 200                 


<210>  4358
<211>  219
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4358

Xaa Arg Phe Val Thr Val Trp Lys Gln Ser Ile Pro Ser Thr Ser Gln 
1               5                   10                  15      


Lys Cys Lys His Pro Glu Asp Ser Glu Asn Asn Phe Phe Glu Gly Phe 
            20                  25                  30          


Pro Ser Arg Tyr Trp Leu Pro Ala Phe Phe Phe Pro Gln Ala Phe Leu 
        35                  40                  45              


Ala Ala Val Leu Gln Asp Tyr Gly Arg Ser Arg Gly Ile Ala Val Asp 
    50                  55                  60                  


Ala Leu Thr Phe Thr His His Val Ile Ser Asn Thr Thr Asp Lys Asp 
65                  70                  75                  80  


Glu Lys Phe Ser Val Phe Met Pro Lys Lys Leu Asn Ile Val Arg Arg 
                85                  90                  95      


Ala Phe Lys Gly Ser Ala Ser Ser His Thr Gly Val Tyr Ile Phe Gly 
            100                 105                 110         


Leu Phe Ile Glu Gly Ala Arg Trp Asn Arg Glu Gln Lys Ile Leu Glu 
        115                 120                 125             


Asp Ser Leu Pro Leu Glu Met Cys Cys Asp Phe Pro Asp Ile Tyr Phe 
    130                 135                 140                 


Leu Pro Thr Lys Ile Ser Thr Lys Thr Pro Asn Ala Ser Asn Gln Thr 
145                 150                 155                 160 


Asp Ser Glu Leu Tyr Ala Phe Glu Cys Pro Val Tyr Gln Thr Pro Glu 
                165                 170                 175     


Arg Ser Arg Ile Leu Ala Thr Thr Gly Leu Pro Thr Asn Phe Leu Thr 
            180                 185                 190         


Ser Val Tyr Leu Ser Thr Lys Lys Pro Pro Ser His Trp Ile Thr Met 
        195                 200                 205             


Arg Val Ala Leu Leu Cys Glu Lys Asn Glu Lys 
    210                 215                 


<210>  4359
<211>  300
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4359

Xaa Thr Gly Val Ser His Arg Ala Asp Gly Glu Arg Gly Thr Val Gly 
1               5                   10                  15      


Ile Asn Leu Pro Thr Gly Glu Cys Ser Ile Phe Gly Tyr Phe Val Asp 
            20                  25                  30          


Ile Glu Gln Cys Glu Phe Ile Pro Trp Ser Asp Leu Val Pro Asn Asp 
        35                  40                  45              


Gln Thr Leu Ile Gln Arg Gly Thr Ser Leu Leu Thr Asn Leu Gln Arg 
    50                  55                  60                  


Ser Gly Gly Asn Phe Leu Lys Ile Thr Glu Cys Gly Glu Cys Ile Asn 
65                  70                  75                  80  


Tyr Thr Ala Thr Arg Asp Thr Thr Cys Leu Ser Phe Leu Met Ser Leu 
                85                  90                  95      


Leu Leu Lys Asn Ser Cys Pro Val Leu Leu Thr Gly Glu Ser Gly Val 
            100                 105                 110         


Gly Lys Thr Ala Ala Ile Asn Gln Met Leu Glu Lys Leu Glu Gly Pro 
        115                 120                 125             


Gly Ala Phe Asp Ile Lys His Gly Ser Ile Leu Gly Asp Thr Leu Leu 
    130                 135                 140                 


Tyr Ser Glu Ile Lys Lys Ser Ser Ser Leu Lys Gln Asn Ile Thr Ile 
145                 150                 155                 160 


Leu Ile Pro Glu Thr His Lys Thr Ala Thr Gly Ser Ser Asp Asn Pro 
                165                 170                 175     


Thr Lys Lys Pro Glu Val Arg Thr Asn Lys Lys Leu Leu Lys Asn Asn 
            180                 185                 190         


Asp His Lys Gly Val Val Val Ser Thr Ile Asn Phe Ser Thr Asn Val 
        195                 200                 205             


Thr Ala Ala Lys Thr Lys Glu Met Ile Leu Lys Lys Leu Ile Arg Arg 
    210                 215                 220                 


Thr Lys Asp Thr Leu Gly Ala Pro Lys Asn Asn Arg Ile Leu Ile Phe 
225                 230                 235                 240 


Ile Asp Asp Met Asn Met Pro Val Ser Asp Met Tyr Gly Ala Gln Pro 
                245                 250                 255     


Pro Leu Glu Leu Ile Arg Gln Leu Leu Asp Leu Gly Gly Val Tyr Asp 
            260                 265                 270         


Thr Glu Lys Asn Thr Trp Lys Asn Ile Gln Asp Leu Ser Ile Val Ala 
        275                 280                 285             


Ala Cys Val Pro Val Val Asn Asp Ile Ser Pro Arg 
    290                 295                 300 


<210>  4360
<211>  358
<212>  PRT
<213>  Homo Sapiens

<400>  4360

Met Ala Pro Gln Asn Leu Ser Thr Phe Cys Leu Leu Leu Leu Tyr Leu 
1               5                   10                  15      


Ile Gly Ala Val Ile Ala Gly Arg Asp Phe Tyr Lys Ile Leu Gly Val 
            20                  25                  30          


Pro Arg Ser Ala Ser Ile Lys Asp Ile Lys Lys Ala Tyr Arg Lys Leu 
        35                  40                  45              


Ala Leu Gln Leu His Pro Asp Arg Asn Pro Asp Asp Pro Gln Ala Gln 
    50                  55                  60                  


Glu Lys Phe Gln Asp Leu Gly Ala Ala Tyr Glu Val Leu Ser Asp Ser 
65                  70                  75                  80  


Glu Lys Arg Lys Gln Tyr Asp Thr Tyr Gly Glu Glu Gly Leu Lys Asp 
                85                  90                  95      


Gly His Gln Ser Ser His Gly Asp Ile Phe Ser His Phe Phe Gly Asp 
            100                 105                 110         


Phe Gly Phe Met Phe Gly Gly Thr Pro Arg Gln Gln Asp Arg Asn Ile 
        115                 120                 125             


Pro Arg Gly Ser Asp Ile Ile Val Asp Leu Glu Val Thr Leu Glu Glu 
    130                 135                 140                 


Val Tyr Ala Gly Asn Phe Val Glu Val Val Arg Asn Lys Pro Val Ala 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Arg Lys Cys Asn Cys Arg Gln Glu Met Arg 
                165                 170                 175     


Thr Thr Gln Leu Gly Pro Gly Arg Phe Gln Met Thr Gln Glu Val Val 
            180                 185                 190         


Cys Asp Glu Cys Pro Asn Val Lys Leu Val Asn Glu Glu Arg Thr Leu 
        195                 200                 205             


Glu Val Glu Ile Glu Pro Gly Val Arg Asp Gly Met Glu Tyr Pro Phe 
    210                 215                 220                 


Ile Gly Glu Gly Glu Pro His Val Asp Gly Glu Pro Gly Asp Leu Arg 
225                 230                 235                 240 


Phe Arg Ile Lys Val Val Lys His Pro Ile Phe Glu Arg Arg Gly Asp 
                245                 250                 255     


Asp Leu Tyr Thr Asn Val Thr Ile Ser Leu Val Glu Ser Leu Val Gly 
            260                 265                 270         


Phe Glu Met Asp Ile Thr His Leu Asp Gly His Lys Val His Ile Ser 
        275                 280                 285             


Arg Asp Lys Ile Thr Arg Pro Gly Ala Lys Leu Trp Lys Lys Gly Glu 
    290                 295                 300                 


Gly Leu Pro Asn Phe Asp Asn Asn Asn Ile Lys Gly Ser Leu Ile Ile 
305                 310                 315                 320 


Thr Phe Asp Val Asp Phe Pro Lys Glu Gln Leu Thr Glu Glu Ala Arg 
                325                 330                 335     


Glu Gly Ile Lys Gln Leu Leu Lys Gln Gly Ser Val Gln Lys Val Tyr 
            340                 345                 350         


Asn Gly Leu Gln Gly Tyr 
        355             


<210>  4361
<211>  358
<212>  PRT
<213>  Homo Sapiens

<400>  4361

Met Ala Pro Gln Asn Leu Ser Thr Phe Cys Leu Leu Leu Leu Tyr Leu 
1               5                   10                  15      


Ile Gly Ala Val Ile Ala Gly Arg Asp Phe Tyr Lys Ile Leu Gly Val 
            20                  25                  30          


Pro Arg Ser Ala Ser Ile Lys Asp Ile Lys Lys Ala Tyr Arg Lys Leu 
        35                  40                  45              


Ala Leu Gln Leu His Pro Asp Arg Asn Pro Asp Asp Pro Gln Ala Gln 
    50                  55                  60                  


Glu Lys Phe Gln Asp Leu Gly Ala Ala Tyr Glu Val Leu Ser Asp Ser 
65                  70                  75                  80  


Glu Lys Arg Lys Gln Tyr Asp Thr Tyr Gly Glu Glu Gly Leu Lys Asp 
                85                  90                  95      


Gly His Gln Ser Ser His Gly Asp Ile Phe Ser His Phe Phe Gly Asp 
            100                 105                 110         


Phe Gly Phe Met Phe Gly Gly Thr Pro Arg Gln Gln Asp Arg Asn Ile 
        115                 120                 125             


Pro Arg Gly Ser Asp Ile Ile Val Asp Leu Glu Val Thr Leu Glu Glu 
    130                 135                 140                 


Val Tyr Ala Gly Asn Phe Val Glu Val Val Arg Asn Lys Pro Val Ala 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Arg Lys Cys Asn Cys Arg Gln Glu Met Arg 
                165                 170                 175     


Thr Thr Gln Leu Gly Pro Gly Arg Phe Gln Met Thr Gln Glu Val Val 
            180                 185                 190         


Cys Asp Glu Cys Pro Asn Val Lys Leu Val Asn Glu Glu Arg Thr Leu 
        195                 200                 205             


Glu Val Glu Ile Glu Pro Gly Val Arg Asp Gly Met Glu Tyr Pro Phe 
    210                 215                 220                 


Ile Gly Glu Gly Glu Pro His Val Asp Gly Glu Pro Gly Asp Leu Arg 
225                 230                 235                 240 


Phe Arg Ile Lys Val Val Lys His Pro Ile Phe Glu Arg Arg Gly Asp 
                245                 250                 255     


Asp Leu Tyr Thr Asn Val Thr Ile Ser Leu Val Glu Ser Leu Val Gly 
            260                 265                 270         


Phe Glu Met Asp Ile Thr His Leu Asp Gly His Lys Val His Ile Ser 
        275                 280                 285             


Arg Asp Lys Ile Thr Arg Pro Gly Ala Lys Leu Trp Lys Lys Gly Glu 
    290                 295                 300                 


Gly Leu Pro Asn Phe Asp Asn Asn Asn Ile Lys Gly Ser Leu Ile Ile 
305                 310                 315                 320 


Thr Phe Asp Val Asp Phe Pro Lys Glu Gln Leu Thr Glu Glu Ala Arg 
                325                 330                 335     


Glu Gly Ile Lys Gln Leu Leu Lys Gln Gly Ser Val Gln Lys Val Tyr 
            340                 345                 350         


Asn Gly Leu Gln Gly Tyr 
        355             


<210>  4362
<211>  223
<212>  PRT
<213>  Homo Sapiens

<400>  4362

Met Ala Thr Pro Gln Ser Ile Phe Ile Phe Ala Ile Cys Ile Leu Met 
1               5                   10                  15      


Ile Thr Glu Leu Ile Leu Ala Ser Lys Ser Tyr Tyr Asp Ile Leu Gly 
            20                  25                  30          


Val Pro Lys Ser Ala Ser Glu Arg Gln Ile Lys Lys Ala Phe His Lys 
        35                  40                  45              


Leu Ala Met Lys Tyr His Pro Asp Lys Asn Lys Ser Pro Asp Ala Glu 
    50                  55                  60                  


Ala Lys Phe Arg Glu Ile Ala Glu Ala Tyr Glu Thr Leu Ser Asp Ala 
65                  70                  75                  80  


Asn Arg Arg Lys Glu Tyr Asp Thr Leu Gly His Ser Ala Phe Thr Ser 
                85                  90                  95      


Gly Lys Gly Gln Arg Gly Ser Gly Ser Ser Phe Glu Gln Ser Phe Asn 
            100                 105                 110         


Phe Asn Phe Asp Asp Leu Phe Lys Asp Phe Gly Phe Phe Gly Gln Asn 
        115                 120                 125             


Gln Asn Thr Gly Ser Lys Lys Arg Phe Glu Asn His Phe Gln Thr Arg 
    130                 135                 140                 


Gln Asp Gly Gly Ser Ser Arg Gln Arg His His Phe Gln Glu Phe Ser 
145                 150                 155                 160 


Phe Gly Gly Gly Leu Phe Asp Asp Met Phe Glu Asp Met Glu Lys Met 
                165                 170                 175     


Phe Ser Phe Ser Gly Phe Asp Ser Thr Asn Gln His Thr Val Gln Thr 
            180                 185                 190         


Glu Asn Arg Phe His Gly Ser Ser Lys His Cys Arg Thr Val Thr Gln 
        195                 200                 205             


Arg Arg Gly Asn Met Val Thr Thr Tyr Thr Asp Cys Ser Gly Gln 
    210                 215                 220             


<210>  4363
<211>  153
<212>  PRT
<213>  Homo Sapiens

<400>  4363

Met Gly Ala Pro Leu Leu Ser Pro Gly Trp Gly Ala Gly Ala Ala Gly 
1               5                   10                  15      


Arg Arg Trp Trp Met Leu Leu Ala Pro Leu Leu Pro Ala Leu Leu Leu 
            20                  25                  30          


Val Arg Pro Ala Gly Ala Leu Val Glu Gly Leu Tyr Cys Gly Thr Arg 
        35                  40                  45              


Asp Cys Tyr Glu Val Leu Gly Val Ser Arg Ser Ala Gly Lys Ala Glu 
    50                  55                  60                  


Ile Ala Arg Ala Tyr Arg Gln Leu Ala Arg Arg Tyr His Pro Asp Arg 
65                  70                  75                  80  


Tyr Arg Pro Gln Pro Gly Asp Glu Gly Pro Gly Arg Thr Pro Gln Ser 
                85                  90                  95      


Ala Glu Glu Ala Phe Leu Leu Val Ala Thr Ala Tyr Glu Thr Leu Lys 
            100                 105                 110         


Val Ser Gln Ala Ala Ala Glu Leu Gln Gln Tyr Cys Met Gln Asn Ala 
        115                 120                 125             


Cys Lys Asp Ala Leu Leu Val Gly Val Pro Ala Gly Ser Asn Pro Phe 
    130                 135                 140                 


Arg Glu Pro Arg Ser Cys Ala Leu Leu 
145                 150             


<210>  4364
<211>  504
<212>  PRT
<213>  Homo Sapiens

<400>  4364

Met Val Ala Pro Gly Ser Val Thr Ser Arg Leu Gly Ser Val Phe Pro 
1               5                   10                  15      


Phe Leu Leu Val Leu Val Asp Leu Gln Tyr Glu Gly Ala Glu Cys Gly 
            20                  25                  30          


Val Asn Ala Asp Val Glu Lys His Leu Glu Leu Gly Lys Lys Leu Leu 
        35                  40                  45              


Ala Ala Gly Gln Leu Ala Asp Ala Leu Ser Gln Phe His Ala Ala Val 
    50                  55                  60                  


Asp Gly Asp Pro Asp Asn Tyr Ile Ala Tyr Tyr Arg Arg Ala Thr Val 
65                  70                  75                  80  


Phe Leu Ala Met Gly Lys Ser Lys Ala Ala Leu Pro Asp Leu Thr Lys 
                85                  90                  95      


Val Ile Gln Leu Lys Met Asp Phe Thr Ala Ala Arg Leu Gln Arg Gly 
            100                 105                 110         


His Leu Leu Leu Lys Gln Gly Lys Leu Asp Glu Ala Glu Asp Asp Phe 
        115                 120                 125             


Lys Lys Val Leu Lys Ser Asn Pro Ser Glu Asn Glu Glu Lys Glu Ala 
    130                 135                 140                 


Gln Ser Gln Leu Ile Lys Ser Asp Glu Met Gln Arg Leu Arg Ser Gln 
145                 150                 155                 160 


Ala Leu Asn Ala Phe Gly Ser Gly Asp Tyr Thr Ala Ala Ile Ala Phe 
                165                 170                 175     


Leu Asp Lys Ile Leu Glu Val Cys Val Trp Asp Ala Glu Leu Arg Glu 
            180                 185                 190         


Leu Arg Ala Glu Cys Phe Ile Lys Glu Gly Glu Pro Arg Lys Ala Ile 
        195                 200                 205             


Ser Asp Leu Lys Ala Ala Ser Lys Leu Lys Asn Asp Asn Thr Glu Ala 
    210                 215                 220                 


Phe Tyr Lys Ile Ser Thr Leu Tyr Tyr Gln Leu Gly Asp His Glu Leu 
225                 230                 235                 240 


Ser Leu Ser Glu Val Arg Glu Cys Leu Lys Leu Asp Gln Asp His Lys 
                245                 250                 255     


Arg Cys Phe Ala His Tyr Lys Gln Val Lys Lys Leu Asn Lys Leu Ile 
            260                 265                 270         


Glu Ser Ala Glu Glu Leu Ile Arg Asp Gly Arg Tyr Thr Asp Ala Thr 
        275                 280                 285             


Ser Lys Tyr Glu Ser Val Met Lys Thr Glu Pro Ser Ile Ala Glu Tyr 
    290                 295                 300                 


Thr Val Arg Ser Lys Glu Arg Ile Cys His Cys Phe Ser Lys Asp Glu 
305                 310                 315                 320 


Lys Pro Val Glu Ala Ile Arg Val Cys Ser Glu Val Leu Gln Met Glu 
                325                 330                 335     


Pro Asp Asn Val Asn Ala Leu Lys Asp Arg Ala Glu Ala Tyr Leu Ile 
            340                 345                 350         


Glu Glu Met Tyr Asp Glu Ala Ile Gln Asp Tyr Glu Thr Ala Gln Glu 
        355                 360                 365             


His Asn Glu Asn Asp Gln Gln Ile Arg Glu Gly Leu Glu Lys Ala Gln 
    370                 375                 380                 


Arg Leu Leu Lys Gln Ser Gln Lys Arg Asp Tyr Tyr Lys Ile Leu Gly 
385                 390                 395                 400 


Val Lys Arg Asn Ala Lys Lys Gln Glu Ile Ile Lys Ala Tyr Arg Lys 
                405                 410                 415     


Leu Ala Leu Gln Trp His Pro Asp Asn Phe Gln Asn Glu Glu Glu Lys 
            420                 425                 430         


Lys Lys Ala Glu Lys Lys Phe Ile Asp Ile Ala Ala Ala Lys Glu Val 
        435                 440                 445             


Leu Ser Asp Pro Glu Met Arg Lys Lys Phe Asp Asp Gly Glu Asp Pro 
    450                 455                 460                 


Leu Asp Ala Glu Ser Gln Gln Gly Gly Gly Gly Asn Pro Phe His Arg 
465                 470                 475                 480 


Ser Trp Asn Ser Trp Gln Gly Phe Asn Pro Phe Ser Ser Gly Gly Pro 
                485                 490                 495     


Phe Arg Phe Lys Phe His Phe Asn 
            500                 


<210>  4365
<211>  453
<212>  PRT
<213>  Homo Sapiens

<400>  4365

Met Val Ala Pro Gly Ser Val Thr Ser Arg Leu Gly Ser Val Phe Pro 
1               5                   10                  15      


Phe Leu Leu Val Leu Val Asp Leu Gln Tyr Glu Gly Ala Glu Cys Gly 
            20                  25                  30          


Val Asn Ala Asp Val Glu Lys His Leu Glu Leu Gly Lys Lys Leu Leu 
        35                  40                  45              


Ala Ala Gly Gln Leu Ala Asp Ala Leu Ser Gln Phe His Ala Ala Val 
    50                  55                  60                  


Asp Gly Asp Pro Asp Asn Tyr Ile Ala Tyr Tyr Arg Arg Ala Thr Val 
65                  70                  75                  80  


Phe Leu Ala Met Gly Lys Ser Lys Ala Ala Leu Pro Asp Leu Thr Lys 
                85                  90                  95      


Val Ile Gln Leu Lys Met Asp Phe Thr Ala Ala Arg Leu Gln Arg Gly 
            100                 105                 110         


His Leu Leu Leu Lys Gln Gly Lys Leu Asp Glu Ala Glu Asp Asp Phe 
        115                 120                 125             


Lys Lys Val Val Cys Val Trp Asp Ala Glu Leu Arg Glu Leu Arg Ala 
    130                 135                 140                 


Glu Cys Phe Ile Lys Glu Gly Glu Pro Arg Lys Ala Ile Ser Asp Leu 
145                 150                 155                 160 


Lys Ala Ala Ser Lys Leu Lys Asn Asp Asn Thr Glu Ala Phe Tyr Lys 
                165                 170                 175     


Ile Ser Thr Leu Tyr Tyr Gln Leu Gly Asp His Glu Leu Ser Leu Ser 
            180                 185                 190         


Glu Val Arg Glu Cys Leu Lys Leu Asp Gln Asp His Lys Arg Cys Phe 
        195                 200                 205             


Ala His Tyr Lys Gln Val Lys Lys Leu Asn Lys Leu Ile Glu Ser Ala 
    210                 215                 220                 


Glu Glu Leu Ile Arg Asp Gly Arg Tyr Thr Asp Ala Thr Ser Lys Tyr 
225                 230                 235                 240 


Glu Ser Val Met Lys Thr Glu Pro Ser Ile Ala Glu Tyr Thr Val Arg 
                245                 250                 255     


Ser Lys Glu Arg Ile Cys His Cys Phe Ser Lys Asp Glu Lys Pro Val 
            260                 265                 270         


Glu Ala Ile Arg Val Cys Ser Glu Val Leu Gln Met Glu Pro Asp Asn 
        275                 280                 285             


Val Asn Ala Leu Lys Asp Arg Ala Glu Ala Tyr Leu Ile Glu Glu Met 
    290                 295                 300                 


Tyr Asp Glu Ala Ile Gln Asp Tyr Glu Thr Ala Gln Glu His Asn Glu 
305                 310                 315                 320 


Asn Asp Gln Gln Ile Arg Glu Gly Leu Glu Lys Ala Gln Arg Leu Leu 
                325                 330                 335     


Lys Gln Ser Gln Lys Arg Asp Tyr Tyr Lys Ile Leu Gly Val Lys Arg 
            340                 345                 350         


Asn Ala Lys Lys Gln Glu Ile Ile Lys Ala Tyr Arg Lys Leu Ala Leu 
        355                 360                 365             


Gln Trp His Pro Asp Asn Phe Gln Asn Glu Glu Glu Lys Lys Lys Ala 
    370                 375                 380                 


Glu Lys Lys Phe Ile Asp Ile Ala Ala Ala Lys Glu Val Leu Ser Asp 
385                 390                 395                 400 


Pro Glu Met Arg Lys Lys Phe Asp Asp Gly Glu Asp Pro Leu Asp Ala 
                405                 410                 415     


Glu Ser Gln Gln Gly Gly Gly Gly Asn Pro Phe His Arg Ser Trp Asn 
            420                 425                 430         


Ser Trp Gln Gly Phe Asn Pro Phe Ser Ser Gly Gly Pro Phe Arg Phe 
        435                 440                 445             


Lys Phe His Phe Asn 
    450             


<210>  4366
<211>  60
<212>  PRT
<213>  Homo Sapiens

<400>  4366

Met Arg Gly Met Lys Leu Leu Gly Ala Leu Leu Ala Leu Ala Ala Leu 
1               5                   10                  15      


Leu Gln Gly Ala Val Ser Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr 
            20                  25                  30          


Phe Gly Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val 
        35                  40                  45              


Gln Gly Cys Thr Arg His Leu Ser Leu Arg Gly Gln 
    50                  55                  60  


<210>  4367
<211>  60
<212>  PRT
<213>  Homo Sapiens

<400>  4367

Met Arg Gly Met Lys Leu Leu Gly Ala Leu Leu Ala Leu Ala Ala Leu 
1               5                   10                  15      


Leu Gln Gly Ala Val Ser Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr 
            20                  25                  30          


Phe Gly Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val 
        35                  40                  45              


Gln Gly Cys Thr Arg His Leu Ser Leu Arg Gly Gln 
    50                  55                  60  


<210>  4368
<211>  60
<212>  PRT
<213>  Homo Sapiens

<400>  4368

Met Arg Gly Met Lys Leu Leu Gly Ala Leu Leu Ala Leu Ala Ala Leu 
1               5                   10                  15      


Leu Gln Gly Ala Val Ser Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr 
            20                  25                  30          


Phe Gly Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val 
        35                  40                  45              


Gln Gly Cys Thr Arg His Leu Ser Leu Arg Gly Gln 
    50                  55                  60  


<210>  4369
<211>  282
<212>  PRT
<213>  Homo Sapiens

<400>  4369

Met Arg Gly Met Lys Leu Leu Gly Ala Leu Leu Ala Leu Ala Ala Leu 
1               5                   10                  15      


Leu Gln Gly Ala Val Ser Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr 
            20                  25                  30          


Phe Gly Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val 
        35                  40                  45              


Gln Ile Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp 
    50                  55                  60                  


Ser His Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp 
65                  70                  75                  80  


Ala Pro Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Asn 
                85                  90                  95      


Ser Tyr Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser 
            100                 105                 110         


Ala Val Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Gly Asn 
        115                 120                 125             


Asp Thr Phe Asn Arg Glu Pro Ala Ile Val Arg Phe Phe Ser Arg Phe 
    130                 135                 140                 


Thr Glu Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly 
145                 150                 155                 160 


Asp Ala Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val 
                165                 170                 175     


Gln Glu Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn 
            180                 185                 190         


Ala Gly Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu 
        195                 200                 205             


Trp Thr Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr 
    210                 215                 220                 


Thr Ala Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly 
225                 230                 235                 240 


Met Leu Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn 
                245                 250                 255     


Phe Gln Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser 
            260                 265                 270         


Asp His Tyr Pro Val Glu Val Met Leu Lys 
        275                 280         


<210>  4370
<211>  282
<212>  PRT
<213>  Homo Sapiens

<400>  4370

Met Arg Gly Met Lys Leu Leu Gly Ala Leu Leu Ala Leu Ala Ala Leu 
1               5                   10                  15      


Leu Gln Gly Ala Val Ser Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr 
            20                  25                  30          


Phe Gly Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val 
        35                  40                  45              


Gln Ile Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp 
    50                  55                  60                  


Ser His Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp 
65                  70                  75                  80  


Ala Pro Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Asn 
                85                  90                  95      


Ser Tyr Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser 
            100                 105                 110         


Ala Val Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Gly Asn 
        115                 120                 125             


Asp Thr Phe Asn Arg Glu Pro Ala Ile Val Arg Phe Phe Ser Arg Phe 
    130                 135                 140                 


Thr Glu Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly 
145                 150                 155                 160 


Asp Ala Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val 
                165                 170                 175     


Gln Glu Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn 
            180                 185                 190         


Ala Gly Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu 
        195                 200                 205             


Trp Thr Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr 
    210                 215                 220                 


Thr Ala Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly 
225                 230                 235                 240 


Met Leu Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn 
                245                 250                 255     


Phe Gln Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser 
            260                 265                 270         


Asp His Tyr Pro Val Glu Val Met Leu Lys 
        275                 280         


<210>  4371
<211>  86
<212>  PRT
<213>  Homo Sapiens

<400>  4371

Met Arg Gly Met Lys Leu Leu Gly Ala Leu Leu Ala Leu Ala Ala Leu 
1               5                   10                  15      


Leu Gln Gly Ala Val Ser Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr 
            20                  25                  30          


Phe Gly Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val 
        35                  40                  45              


Gln Ile Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp 
    50                  55                  60                  


Ser His Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Trp 
65                  70                  75                  80  


Val Thr Val Ala Gly Ser 
                85      


<210>  4372
<211>  108
<212>  PRT
<213>  Homo Sapiens

<400>  4372

Asn Arg Glu Pro Ala Ile Val Arg Phe Phe Ser Arg Phe Thr Glu Val 
1               5                   10                  15      


Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly Asp Ala Val 
            20                  25                  30          


Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Gln Glu Lys 
        35                  40                  45              


Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn Ala Gly Cys 
    50                  55                  60                  


Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu Trp Thr Ser 
65                  70                  75                  80  


Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr 
                85                  90                  95      


Pro Thr His Cys Ala Tyr Asp Arg Leu Pro Met Ala 
            100                 105             


<210>  4373
<211>  72
<212>  PRT
<213>  Homo Sapiens

<400>  4373

Ser Ile Arg Leu Trp Thr Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp 
1               5                   10                  15      


Ser Ala Asp Thr Thr Ala Thr Pro Thr His Cys Ala Tyr Asp Arg Ile 
            20                  25                  30          


Val Val Ala Gly Met Leu Leu Arg Gly Ala Val Val Pro Asp Ser Ala 
        35                  40                  45              


Leu Pro Phe Asn Phe Gln Ala Ala Tyr Gly Leu Ser Asp Gln Leu Val 
    50                  55                  60                  


Cys Val Leu Pro Cys Thr Ala Thr 
65                  70          


<210>  4374
<211>  90
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4374

Xaa His Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu 
1               5                   10                  15      


Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val Asp Ser 
            20                  25                  30          


Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Gly Asn Asp Thr Phe Asn 
        35                  40                  45              


Arg Glu Pro Ala Ile Val Arg Phe Phe Ser Arg Phe Thr Gly Ser Val 
    50                  55                  60                  


Pro His Thr Thr Trp Leu Ser Pro Gln Arg Ser Gly Ser Leu Pro Leu 
65                  70                  75                  80  


Phe Pro Cys Met Arg Pro Arg Gly Thr Gln 
                85                  90  


<210>  4375
<211>  75
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4375

Xaa Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser Ala Val Asp 
1               5                   10                  15      


Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Gly Asn Asp Thr Phe 
            20                  25                  30          


Asn Arg Glu Pro Ala Ile Val Arg Phe Phe Ser Arg Phe Thr Gly Ser 
        35                  40                  45              


Val Pro His Thr Thr Trp Leu Ser Pro Gln Arg Ser Gly Ser Leu Pro 
    50                  55                  60                  


Leu Phe Pro Cys Met Arg Pro Arg Gly Thr Gln 
65                  70                  75  


<210>  4376
<211>  65
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4376

Xaa Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr 
1               5                   10                  15      


Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Met Leu Leu 
            20                  25                  30          


Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn Phe Gln Ala 
        35                  40                  45              


Ala Tyr Gly Leu Ser Asp Gln Leu Val Cys Val Leu Pro Cys Thr Ala 
    50                  55                  60                  


Thr 
65  


<210>  4377
<211>  26
<212>  PRT
<213>  Homo Sapiens

<400>  4377

Met His Tyr Pro Thr Ala Leu Leu Phe Leu Ile Leu Ala Asn Gly Ala 
1               5                   10                  15      


Gln Ala Phe Arg Ile Cys Ala Phe Asn Ala 
            20                  25      


<210>  4378
<211>  85
<212>  PRT
<213>  Homo Sapiens

<400>  4378

Met His Tyr Pro Thr Ala Leu Leu Phe Leu Ile Leu Ala Asn Gly Ala 
1               5                   10                  15      


Gln Ala Phe Arg Ile Cys Ala Phe Asn Ala Gln Arg Leu Thr Leu Ala 
            20                  25                  30          


Lys Val Ala Arg Glu Gln Val Met Asp Thr Leu Val Arg Ala Leu Asn 
        35                  40                  45              


Ile Ser Asp His Tyr Pro Val Glu Val Glu Leu Lys Leu Ser Gln Ala 
    50                  55                  60                  


His Ser Val Gln Pro Leu Ser Leu Thr Val Leu Leu Leu Leu Ser Leu 
65                  70                  75                  80  


Leu Ser Pro Gln Leu 
                85  


<210>  4379
<211>  62
<212>  PRT
<213>  Homo Sapiens

<400>  4379

Met His Tyr Pro Thr Ala Leu Leu Phe Leu Ile Leu Ala Asn Gly Ala 
1               5                   10                  15      


Gln Ala Phe Arg Ile Cys Ala Phe Asn Ala Gln Arg Leu Thr Leu Ala 
            20                  25                  30          


Lys Val Ala Arg Glu Gln Val Met Asp Thr Leu Val Arg Asp Val Ile 
        35                  40                  45              


Leu Leu Gly Asp Phe Asn Ala Asp Cys Ala Ser Leu Thr Lys 
    50                  55                  60          


<210>  4380
<211>  104
<212>  PRT
<213>  Homo Sapiens

<400>  4380

Met His Tyr Pro Thr Ala Leu Leu Phe Leu Ile Leu Ala Asn Gly Ala 
1               5                   10                  15      


Gln Ala Phe Arg Ile Cys Ala Phe Asn Ala Gln Arg Leu Thr Leu Ala 
            20                  25                  30          


Lys Val Ala Arg Glu Gln Val Met Asp Thr Leu Val Arg Ile Leu Ala 
        35                  40                  45              


Arg Cys Asp Ile Met Val Leu Gln Glu Val Val Asp Ser Ser Gly Ser 
    50                  55                  60                  


Ala Ile Pro Leu Leu Leu Arg Glu Leu Asn Arg Phe Asp Gly Ser Gly 
65                  70                  75                  80  


Pro Tyr Ser Thr Leu Ser Ser Pro Gln Leu Gly Arg Ser Thr Tyr Met 
                85                  90                  95      


Glu Thr Tyr Val Tyr Phe Tyr Arg 
            100                 


<210>  4381
<211>  208
<212>  PRT
<213>  Homo Sapiens

<400>  4381

Met His Tyr Pro Thr Ala Leu Leu Phe Leu Ile Leu Ala Asn Gly Ala 
1               5                   10                  15      


Gln Ala Phe Arg Ile Cys Ala Phe Asn Ala Gln Arg Leu Thr Leu Ala 
            20                  25                  30          


Lys Val Ala Arg Glu Gln Val Met Asp Thr Leu Val Arg Ile Leu Ala 
        35                  40                  45              


Arg Cys Asp Ile Met Val Leu Gln Glu Val Val Asp Ser Ser Gly Ser 
    50                  55                  60                  


Ala Ile Pro Leu Leu Leu Arg Glu Leu Asn Arg Phe Asp Gly Ser Gly 
65                  70                  75                  80  


Pro Tyr Ser Thr Leu Ser Ser Pro Gln Leu Gly Arg Ser Thr Tyr Met 
                85                  90                  95      


Glu Thr Tyr Val Tyr Phe Tyr Arg Ser His Lys Thr Gln Val Leu Ser 
            100                 105                 110         


Ser Tyr Val Tyr Asn Asp Glu Asp Asp Val Phe Ala Arg Glu Pro Phe 
        115                 120                 125             


Val Ala Gln Phe Ser Leu Pro Ser Asn Val Leu Pro Ser Leu Val Leu 
    130                 135                 140                 


Val Pro Leu His Thr Thr Pro Lys Ala Val Glu Lys Glu Leu Asn Ala 
145                 150                 155                 160 


Leu Tyr Asp Val Phe Leu Glu Val Ser Gln His Trp Gln Ser Lys Asp 
                165                 170                 175     


Val Ile Leu Leu Gly Asp Phe Asn Ala Asp Cys Ala Ser Leu Thr Lys 
            180                 185                 190         


Lys Arg Leu Asp Lys Leu Glu Leu Arg Thr Glu Pro Gly Phe His Trp 
        195                 200                 205             


<210>  4382
<211>  302
<212>  PRT
<213>  Homo Sapiens

<400>  4382

Met His Tyr Pro Thr Ala Leu Leu Phe Leu Ile Leu Ala Asn Gly Ala 
1               5                   10                  15      


Gln Ala Phe Arg Ile Cys Ala Phe Asn Ala Gln Arg Leu Thr Leu Ala 
            20                  25                  30          


Lys Val Ala Arg Glu Gln Val Met Asp Thr Leu Val Arg Ile Leu Ala 
        35                  40                  45              


Arg Cys Asp Ile Met Val Leu Gln Glu Val Val Asp Ser Ser Gly Ser 
    50                  55                  60                  


Ala Ile Pro Leu Leu Leu Arg Glu Leu Asn Arg Phe Asp Gly Ser Gly 
65                  70                  75                  80  


Pro Tyr Ser Thr Leu Ser Ser Pro Gln Leu Gly Arg Ser Thr Tyr Met 
                85                  90                  95      


Glu Thr Tyr Val Tyr Phe Tyr Arg Ser His Lys Thr Gln Val Leu Ser 
            100                 105                 110         


Ser Tyr Val Tyr Asn Asp Glu Asp Asp Val Phe Ala Arg Glu Pro Phe 
        115                 120                 125             


Val Ala Gln Phe Ser Leu Pro Ser Asn Val Leu Pro Ser Leu Val Leu 
    130                 135                 140                 


Val Pro Leu His Thr Thr Pro Lys Ala Val Glu Lys Glu Leu Asn Ala 
145                 150                 155                 160 


Leu Tyr Asp Val Phe Leu Glu Val Ser Gln His Trp Gln Ser Lys Asp 
                165                 170                 175     


Val Ile Leu Leu Gly Asp Phe Asn Ala Asp Cys Ala Ser Leu Thr Lys 
            180                 185                 190         


Lys Arg Leu Asp Lys Leu Glu Leu Arg Thr Glu Pro Gly Phe His Trp 
        195                 200                 205             


Val Ile Ala Asp Gly Glu Asp Thr Thr Val Arg Ala Ser Thr His Cys 
    210                 215                 220                 


Thr Tyr Asp Arg Val Val Leu His Gly Glu Arg Cys Arg Ser Leu Leu 
225                 230                 235                 240 


His Thr Ala Ala Ala Phe Asp Phe Pro Thr Ser Phe Gln Leu Thr Glu 
                245                 250                 255     


Glu Glu Ala Leu Asn Ile Ser Asp His Tyr Pro Val Glu Val Glu Leu 
            260                 265                 270         


Lys Leu Ser Gln Ala His Ser Val Gln Pro Leu Ser Leu Thr Val Leu 
        275                 280                 285             


Leu Leu Leu Ser Leu Leu Ser Pro Gln Leu Cys Pro Ala Ala 
    290                 295                 300         


<210>  4383
<211>  302
<212>  PRT
<213>  Homo Sapiens

<400>  4383

Met His Tyr Pro Thr Ala Leu Leu Phe Leu Ile Leu Ala Asn Gly Ala 
1               5                   10                  15      


Gln Ala Phe Arg Ile Cys Ala Phe Asn Ala Gln Arg Leu Thr Leu Ala 
            20                  25                  30          


Lys Val Ala Arg Glu Gln Val Met Asp Thr Leu Val Arg Ile Leu Ala 
        35                  40                  45              


Arg Cys Asp Ile Met Val Leu Gln Glu Val Val Asp Ser Ser Gly Ser 
    50                  55                  60                  


Ala Ile Pro Leu Leu Leu Arg Glu Leu Asn Arg Phe Asp Gly Ser Gly 
65                  70                  75                  80  


Pro Tyr Ser Thr Leu Ser Ser Pro Gln Leu Gly Arg Ser Thr Tyr Met 
                85                  90                  95      


Glu Thr Tyr Val Tyr Phe Tyr Arg Ser His Lys Thr Gln Val Leu Ser 
            100                 105                 110         


Ser Tyr Val Tyr Asn Asp Glu Asp Asp Val Phe Ala Arg Glu Pro Phe 
        115                 120                 125             


Val Ala Gln Phe Ser Leu Pro Ser Asn Val Leu Pro Ser Leu Val Leu 
    130                 135                 140                 


Val Pro Leu His Thr Thr Pro Lys Ala Val Glu Lys Glu Leu Asn Ala 
145                 150                 155                 160 


Leu Tyr Asp Val Phe Leu Glu Val Ser Gln His Trp Gln Ser Lys Asp 
                165                 170                 175     


Val Ile Leu Leu Gly Asp Phe Asn Ala Asp Cys Ala Ser Leu Thr Lys 
            180                 185                 190         


Lys Arg Leu Asp Lys Leu Glu Leu Arg Thr Glu Pro Gly Phe His Trp 
        195                 200                 205             


Val Ile Ala Asp Gly Glu Asp Thr Thr Val Arg Ala Ser Thr His Cys 
    210                 215                 220                 


Thr Tyr Asp Arg Val Val Leu His Gly Glu Arg Cys Arg Ser Leu Leu 
225                 230                 235                 240 


His Thr Ala Ala Ala Phe Asp Phe Pro Thr Ser Phe Gln Leu Thr Glu 
                245                 250                 255     


Glu Glu Ala Leu Asn Ile Ser Asp His Tyr Pro Val Glu Val Glu Leu 
            260                 265                 270         


Lys Leu Ser Gln Ala His Ser Val Gln Pro Leu Ser Leu Thr Val Leu 
        275                 280                 285             


Leu Leu Leu Ser Leu Leu Ser Pro Gln Leu Cys Pro Ala Ala 
    290                 295                 300         


<210>  4384
<211>  302
<212>  PRT
<213>  Homo Sapiens

<400>  4384

Met His Tyr Pro Thr Ala Leu Leu Phe Leu Ile Leu Ala Asn Gly Ala 
1               5                   10                  15      


Gln Ala Phe Arg Ile Cys Ala Phe Asn Ala Gln Arg Leu Thr Leu Ala 
            20                  25                  30          


Lys Val Ala Arg Glu Gln Val Met Asp Thr Leu Val Arg Ile Leu Ala 
        35                  40                  45              


Arg Cys Asp Ile Met Val Leu Gln Glu Val Val Asp Ser Ser Gly Ser 
    50                  55                  60                  


Ala Ile Pro Leu Leu Leu Arg Glu Leu Asn Arg Phe Asp Gly Ser Gly 
65                  70                  75                  80  


Pro Tyr Ser Thr Leu Ser Ser Pro Gln Leu Gly Arg Ser Thr Tyr Met 
                85                  90                  95      


Glu Thr Tyr Val Tyr Phe Tyr Arg Ser His Lys Thr Gln Val Leu Ser 
            100                 105                 110         


Ser Tyr Val Tyr Asn Asp Glu Asp Asp Val Phe Ala Arg Glu Pro Phe 
        115                 120                 125             


Val Ala Gln Phe Ser Leu Pro Ser Asn Val Leu Pro Ser Leu Val Leu 
    130                 135                 140                 


Val Pro Leu His Thr Thr Pro Lys Ala Val Glu Lys Glu Leu Asn Ala 
145                 150                 155                 160 


Leu Tyr Asp Val Phe Leu Glu Val Ser Gln His Trp Gln Ser Lys Asp 
                165                 170                 175     


Val Ile Leu Leu Gly Asp Phe Asn Ala Asp Cys Ala Ser Leu Thr Lys 
            180                 185                 190         


Lys Arg Leu Asp Lys Leu Glu Leu Arg Thr Glu Pro Gly Phe His Trp 
        195                 200                 205             


Val Ile Ala Asp Gly Glu Asp Thr Thr Val Arg Ala Ser Thr His Cys 
    210                 215                 220                 


Thr Tyr Asp Arg Val Val Leu His Gly Glu Arg Cys Arg Ser Leu Leu 
225                 230                 235                 240 


His Thr Ala Ala Ala Phe Asp Phe Pro Thr Ser Phe Gln Leu Thr Glu 
                245                 250                 255     


Glu Glu Ala Leu Asn Ile Ser Asp His Tyr Pro Val Glu Val Glu Leu 
            260                 265                 270         


Lys Leu Ser Gln Ala His Ser Val Gln Pro Leu Ser Leu Thr Val Leu 
        275                 280                 285             


Leu Leu Leu Ser Leu Leu Ser Pro Gln Leu Cys Pro Ala Ala 
    290                 295                 300         


<210>  4385
<211>  302
<212>  PRT
<213>  Homo Sapiens

<400>  4385

Met His Tyr Pro Thr Ala Leu Leu Phe Leu Ile Leu Ala Asn Gly Ala 
1               5                   10                  15      


Gln Ala Phe Arg Ile Cys Ala Phe Asn Ala Gln Arg Leu Thr Leu Ala 
            20                  25                  30          


Lys Val Ala Arg Glu Gln Val Met Asp Thr Leu Val Arg Ile Leu Ala 
        35                  40                  45              


Arg Cys Asp Ile Met Val Leu Gln Glu Val Val Asp Ser Ser Gly Ser 
    50                  55                  60                  


Ala Ile Pro Leu Leu Leu Arg Glu Leu Asn Arg Phe Asp Gly Ser Gly 
65                  70                  75                  80  


Pro Tyr Ser Thr Leu Ser Ser Pro Gln Leu Gly Arg Ser Thr Tyr Met 
                85                  90                  95      


Glu Thr Tyr Val Tyr Phe Tyr Arg Ser His Lys Thr Gln Val Leu Ser 
            100                 105                 110         


Ser Tyr Val Tyr Asn Asp Glu Asp Asp Val Phe Ala Arg Glu Pro Phe 
        115                 120                 125             


Val Ala Gln Phe Ser Leu Pro Ser Asn Val Leu Pro Ser Leu Val Leu 
    130                 135                 140                 


Val Pro Leu His Thr Thr Pro Lys Ala Val Glu Lys Glu Leu Asn Ala 
145                 150                 155                 160 


Leu Tyr Asp Val Phe Leu Glu Val Ser Gln His Trp Gln Ser Lys Asp 
                165                 170                 175     


Val Ile Leu Leu Gly Asp Phe Asn Ala Asp Cys Ala Ser Leu Thr Lys 
            180                 185                 190         


Lys Arg Leu Asp Lys Leu Glu Leu Arg Thr Glu Pro Gly Phe His Trp 
        195                 200                 205             


Val Ile Ala Asp Gly Glu Asp Thr Thr Val Arg Ala Ser Thr His Cys 
    210                 215                 220                 


Thr Tyr Asp Arg Val Val Leu His Gly Glu Arg Cys Arg Ser Leu Leu 
225                 230                 235                 240 


His Thr Ala Ala Ala Phe Asp Phe Pro Thr Ser Phe Gln Leu Thr Glu 
                245                 250                 255     


Glu Glu Ala Leu Asn Ile Ser Asp His Tyr Pro Val Glu Val Glu Leu 
            260                 265                 270         


Lys Leu Ser Gln Ala His Ser Val Gln Pro Leu Ser Leu Thr Val Leu 
        275                 280                 285             


Leu Leu Leu Ser Leu Leu Ser Pro Gln Leu Cys Pro Ala Ala 
    290                 295                 300         


<210>  4386
<211>  302
<212>  PRT
<213>  Homo Sapiens

<400>  4386

Met His Tyr Pro Thr Ala Leu Leu Phe Leu Ile Leu Ala Asn Gly Ala 
1               5                   10                  15      


Gln Ala Phe Arg Ile Cys Ala Phe Asn Ala Gln Arg Leu Thr Leu Ala 
            20                  25                  30          


Lys Val Ala Arg Glu Gln Val Met Asp Thr Leu Val Arg Ile Leu Ala 
        35                  40                  45              


Arg Cys Asp Ile Met Val Leu Gln Glu Val Val Asp Ser Ser Gly Ser 
    50                  55                  60                  


Ala Ile Pro Leu Leu Leu Arg Glu Leu Asn Arg Phe Asp Gly Ser Gly 
65                  70                  75                  80  


Pro Tyr Ser Thr Leu Ser Ser Pro Gln Leu Gly Arg Ser Thr Tyr Met 
                85                  90                  95      


Glu Thr Tyr Val Tyr Phe Tyr Arg Ser His Lys Thr Gln Val Leu Ser 
            100                 105                 110         


Ser Tyr Val Tyr Asn Asp Glu Asp Asp Val Phe Ala Arg Glu Pro Phe 
        115                 120                 125             


Val Ala Gln Phe Ser Leu Pro Ser Asn Val Leu Pro Ser Leu Val Leu 
    130                 135                 140                 


Val Pro Leu His Thr Thr Pro Lys Ala Val Glu Lys Glu Leu Asn Ala 
145                 150                 155                 160 


Leu Tyr Asp Val Phe Leu Glu Val Ser Gln His Trp Gln Ser Lys Asp 
                165                 170                 175     


Val Ile Leu Leu Gly Asp Phe Asn Ala Asp Cys Ala Ser Leu Thr Lys 
            180                 185                 190         


Lys Arg Leu Asp Lys Leu Glu Leu Arg Thr Glu Pro Gly Phe His Trp 
        195                 200                 205             


Val Ile Ala Asp Gly Glu Asp Thr Thr Val Arg Ala Ser Thr His Cys 
    210                 215                 220                 


Thr Tyr Asp Arg Val Val Leu His Gly Glu Arg Cys Arg Ser Leu Leu 
225                 230                 235                 240 


His Thr Ala Ala Ala Phe Asp Phe Pro Thr Ser Phe Gln Leu Thr Glu 
                245                 250                 255     


Glu Glu Ala Leu Asn Ile Ser Asp His Tyr Pro Val Glu Val Glu Leu 
            260                 265                 270         


Lys Leu Ser Gln Ala His Ser Val Gln Pro Leu Ser Leu Thr Val Leu 
        275                 280                 285             


Leu Leu Leu Ser Leu Leu Ser Pro Gln Leu Cys Pro Ala Ala 
    290                 295                 300         


<210>  4387
<211>  302
<212>  PRT
<213>  Homo Sapiens

<400>  4387

Met His Tyr Pro Thr Ala Leu Leu Phe Leu Ile Leu Ala Asn Gly Ala 
1               5                   10                  15      


Gln Ala Phe Arg Ile Cys Ala Phe Asn Ala Gln Arg Leu Thr Leu Ala 
            20                  25                  30          


Lys Val Ala Arg Glu Gln Val Met Asp Thr Leu Val Arg Ile Leu Ala 
        35                  40                  45              


Arg Cys Asp Ile Met Val Leu Gln Glu Val Val Asp Ser Ser Gly Ser 
    50                  55                  60                  


Ala Ile Pro Leu Leu Leu Arg Glu Leu Asn Arg Phe Asp Gly Ser Gly 
65                  70                  75                  80  


Pro Tyr Ser Thr Leu Ser Ser Pro Gln Leu Gly Arg Ser Thr Tyr Met 
                85                  90                  95      


Glu Thr Tyr Val Tyr Phe Tyr Arg Ser His Lys Thr Gln Val Leu Ser 
            100                 105                 110         


Ser Tyr Val Tyr Asn Asp Glu Asp Asp Val Phe Ala Arg Glu Pro Phe 
        115                 120                 125             


Val Ala Gln Phe Ser Leu Pro Ser Asn Val Leu Pro Ser Leu Val Leu 
    130                 135                 140                 


Val Pro Leu His Thr Thr Pro Lys Ala Val Glu Lys Glu Leu Asn Ala 
145                 150                 155                 160 


Leu Tyr Asp Val Phe Leu Glu Val Ser Gln His Trp Gln Ser Lys Asp 
                165                 170                 175     


Val Ile Leu Leu Gly Asp Phe Asn Ala Asp Cys Ala Ser Leu Thr Lys 
            180                 185                 190         


Lys Arg Leu Asp Lys Leu Glu Leu Arg Thr Glu Pro Gly Phe His Trp 
        195                 200                 205             


Val Ile Ala Asp Gly Glu Asp Thr Thr Val Arg Ala Ser Thr His Cys 
    210                 215                 220                 


Thr Tyr Asp Arg Val Val Leu His Gly Glu Arg Cys Arg Ser Leu Leu 
225                 230                 235                 240 


His Thr Ala Ala Ala Phe Asp Phe Pro Thr Ser Phe Gln Leu Thr Glu 
                245                 250                 255     


Glu Glu Ala Leu Asn Ile Ser Asp His Tyr Pro Val Glu Val Glu Leu 
            260                 265                 270         


Lys Leu Ser Gln Ala His Ser Val Gln Pro Leu Ser Leu Thr Val Leu 
        275                 280                 285             


Leu Leu Leu Ser Leu Leu Ser Pro Gln Leu Cys Pro Ala Ala 
    290                 295                 300         


<210>  4388
<211>  278
<212>  PRT
<213>  Homo Sapiens

<400>  4388

Met Gly Gly Pro Arg Ala Leu Leu Ala Ala Leu Trp Ala Leu Glu Ala 
1               5                   10                  15      


Ala Gly Thr Ala Ala Leu Arg Ile Gly Ala Phe Asn Ile Gln Ser Phe 
            20                  25                  30          


Gly Asp Ser Lys Val Ser Asp Pro Ala Cys Gly Ser Ile Ile Ala Lys 
        35                  40                  45              


Ile Leu Ala Gly Tyr Asp Leu Ala Leu Val Gln Glu Val Arg Asp Pro 
    50                  55                  60                  


Asp Leu Ser Ala Val Ser Ala Leu Met Glu Gln Ile Asn Ser Val Ser 
65                  70                  75                  80  


Glu His Glu Tyr Ser Phe Val Ser Ser Gln Pro Leu Gly Arg Asp Gln 
                85                  90                  95      


Tyr Lys Glu Met Tyr Leu Phe Val Tyr Arg Lys Asp Ala Val Ser Val 
            100                 105                 110         


Val Asp Thr Tyr Leu Tyr Pro Asp Pro Glu Asp Val Phe Ser Arg Glu 
        115                 120                 125             


Pro Phe Val Val Lys Phe Ser Ala Pro Gly Thr Ala Gln Asn Leu Val 
    130                 135                 140                 


Leu Ile Pro Leu His Ala Ala Pro His Gln Ala Val Ala Glu Ile Asp 
145                 150                 155                 160 


Ala Leu Tyr Asp Val Tyr Leu Asp Val Ile Asp Lys Trp Gly Thr Asp 
                165                 170                 175     


Asp Met Leu Phe Leu Gly Asp Phe Asn Ala Asp Cys Ser Tyr Val Arg 
            180                 185                 190         


Ala Gln Asp Trp Ala Ala Ile Arg Leu Arg Ser Ser Glu Val Phe Lys 
        195                 200                 205             


Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Val Gly Asn Ser Asp Cys 
    210                 215                 220                 


Ala Tyr Asp Arg Ile Val Ala Cys Gly Ala Arg Leu Arg Arg Ser Leu 
225                 230                 235                 240 


Lys Pro Gln Ser Ala Thr Val His Asp Phe Gln Glu Glu Phe Gly Leu 
                245                 250                 255     


Asp Gln Thr Gln Ala Leu Ala Ile Ser Asp His Phe Pro Val Glu Val 
            260                 265                 270         


Thr Leu Lys Phe His Arg 
        275             


<210>  4389
<211>  278
<212>  PRT
<213>  Homo Sapiens

<400>  4389

Met Gly Gly Pro Arg Ala Leu Leu Ala Ala Leu Trp Ala Leu Glu Ala 
1               5                   10                  15      


Ala Gly Thr Ala Ala Leu Arg Ile Gly Ala Phe Asn Ile Gln Ser Phe 
            20                  25                  30          


Gly Asp Ser Lys Val Ser Asp Pro Ala Cys Gly Ser Ile Ile Ala Lys 
        35                  40                  45              


Ile Leu Ala Gly Tyr Asp Leu Ala Leu Val Gln Glu Val Arg Asp Pro 
    50                  55                  60                  


Asp Leu Ser Ala Val Ser Ala Leu Met Glu Gln Ile Asn Ser Val Ser 
65                  70                  75                  80  


Glu His Glu Tyr Ser Phe Val Ser Ser Gln Pro Leu Gly Arg Asp Gln 
                85                  90                  95      


Tyr Lys Glu Met Tyr Leu Phe Val Tyr Arg Lys Asp Ala Val Ser Val 
            100                 105                 110         


Val Asp Thr Tyr Leu Tyr Pro Asp Pro Glu Asp Val Phe Ser Arg Glu 
        115                 120                 125             


Pro Phe Val Val Lys Phe Ser Ala Pro Gly Thr Ala Gln Asn Leu Val 
    130                 135                 140                 


Leu Ile Pro Leu His Ala Ala Pro His Gln Ala Val Ala Glu Ile Asp 
145                 150                 155                 160 


Ala Leu Tyr Asp Val Tyr Leu Asp Val Ile Asp Lys Trp Gly Thr Asp 
                165                 170                 175     


Asp Met Leu Phe Leu Gly Asp Phe Asn Ala Asp Cys Ser Tyr Val Arg 
            180                 185                 190         


Ala Gln Asp Trp Ala Ala Ile Arg Leu Arg Ser Ser Glu Val Phe Lys 
        195                 200                 205             


Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Val Gly Asn Ser Asp Cys 
    210                 215                 220                 


Ala Tyr Asp Arg Ile Val Ala Cys Gly Ala Arg Leu Arg Arg Ser Leu 
225                 230                 235                 240 


Lys Pro Gln Ser Ala Thr Val His Asp Phe Gln Glu Glu Phe Gly Leu 
                245                 250                 255     


Asp Gln Thr Gln Ala Leu Ala Ile Ser Asp His Phe Pro Val Glu Val 
            260                 265                 270         


Thr Leu Lys Phe His Arg 
        275             


<210>  4390
<211>  299
<212>  PRT
<213>  Homo Sapiens

<400>  4390

Met Gly Gly Pro Arg Ala Leu Leu Ala Ala Leu Trp Ala Leu Glu Ala 
1               5                   10                  15      


Ala Gly Thr Ala Ala Leu Arg Ile Gly Ala Phe Asn Ile Gln Ser Phe 
            20                  25                  30          


Gly Asp Ser Lys Val Ser Asp Pro Ala Cys Gly Ser Ile Ile Ala Lys 
        35                  40                  45              


Ile Leu Ala Gly Tyr Asp Leu Ala Leu Val Gln Glu Val Arg Asp Pro 
    50                  55                  60                  


Asp Leu Ser Ala Val Ser Ala Leu Met Glu Gln Ile Asn Ser Val Ser 
65                  70                  75                  80  


Glu His Glu Tyr Ser Phe Val Ser Ser Gln Pro Leu Gly Arg Asp Gln 
                85                  90                  95      


Tyr Lys Glu Met Tyr Leu Phe Val Tyr Arg Lys Asp Ala Val Ser Val 
            100                 105                 110         


Val Asp Thr Tyr Leu Tyr Pro Asp Pro Glu Asp Val Phe Ser Arg Glu 
        115                 120                 125             


Pro Phe Val Val Lys Phe Ser Ala Pro Gly Thr Gly Glu Arg Ala Pro 
    130                 135                 140                 


Pro Leu Pro Ser Arg Arg Ala Leu Thr Pro Pro Pro Leu Pro Ala Ala 
145                 150                 155                 160 


Ala Gln Asn Leu Val Leu Ile Pro Leu His Ala Ala Pro His Gln Ala 
                165                 170                 175     


Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Ile Asp 
            180                 185                 190         


Lys Trp Gly Thr Asp Asp Met Leu Phe Leu Gly Asp Phe Asn Ala Asp 
        195                 200                 205             


Cys Ser Tyr Val Arg Ala Gln Asp Trp Ala Ala Ile Arg Leu Arg Ser 
    210                 215                 220                 


Ser Glu Val Phe Lys Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Val 
225                 230                 235                 240 


Gly Asn Ser Asp Cys Ala Tyr Asp Arg Ile Val Ala Cys Gly Ala Arg 
                245                 250                 255     


Leu Arg Arg Ser Leu Lys Pro Gln Ser Ala Thr Val His Asp Phe Gln 
            260                 265                 270         


Glu Glu Phe Gly Leu Asp Gln Thr Gln Ala Leu Ala Ile Ser Asp His 
        275                 280                 285             


Phe Pro Val Glu Val Thr Leu Lys Phe His Arg 
    290                 295                 


<210>  4391
<211>  299
<212>  PRT
<213>  Homo Sapiens

<400>  4391

Met Gly Gly Pro Arg Ala Leu Leu Ala Ala Leu Trp Ala Leu Glu Ala 
1               5                   10                  15      


Ala Gly Thr Ala Ala Leu Arg Ile Gly Ala Phe Asn Ile Gln Ser Phe 
            20                  25                  30          


Gly Asp Ser Lys Val Ser Asp Pro Ala Cys Gly Ser Ile Ile Ala Lys 
        35                  40                  45              


Ile Leu Ala Gly Tyr Asp Leu Ala Leu Val Gln Glu Val Arg Asp Pro 
    50                  55                  60                  


Asp Leu Ser Ala Val Ser Ala Leu Met Glu Gln Ile Asn Ser Val Ser 
65                  70                  75                  80  


Glu His Glu Tyr Ser Phe Val Ser Ser Gln Pro Leu Gly Arg Asp Gln 
                85                  90                  95      


Tyr Lys Glu Met Tyr Leu Phe Val Tyr Arg Lys Asp Ala Val Ser Val 
            100                 105                 110         


Val Asp Thr Tyr Leu Tyr Pro Asp Pro Glu Asp Val Phe Ser Arg Glu 
        115                 120                 125             


Pro Phe Val Val Lys Phe Ser Ala Pro Gly Thr Gly Glu Arg Ala Pro 
    130                 135                 140                 


Pro Leu Pro Ser Arg Arg Ala Leu Thr Pro Pro Pro Leu Pro Ala Ala 
145                 150                 155                 160 


Ala Gln Asn Leu Val Leu Ile Pro Leu His Ala Ala Pro His Gln Ala 
                165                 170                 175     


Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Ile Asp 
            180                 185                 190         


Lys Trp Gly Thr Asp Asp Met Leu Phe Leu Gly Asp Phe Asn Ala Asp 
        195                 200                 205             


Cys Ser Tyr Val Arg Ala Gln Asp Trp Ala Ala Ile Arg Leu Arg Ser 
    210                 215                 220                 


Ser Glu Val Phe Lys Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Val 
225                 230                 235                 240 


Gly Asn Ser Asp Cys Ala Tyr Asp Arg Ile Val Ala Cys Gly Ala Arg 
                245                 250                 255     


Leu Arg Arg Ser Leu Lys Pro Gln Ser Ala Thr Val His Asp Phe Gln 
            260                 265                 270         


Glu Glu Phe Gly Leu Asp Gln Thr Gln Ala Leu Ala Ile Ser Asp His 
        275                 280                 285             


Phe Pro Val Glu Val Thr Leu Lys Phe His Arg 
    290                 295                 


<210>  4392
<211>  299
<212>  PRT
<213>  Homo Sapiens

<400>  4392

Met Gly Gly Pro Arg Ala Leu Leu Ala Ala Leu Trp Ala Leu Glu Ala 
1               5                   10                  15      


Ala Gly Thr Ala Ala Leu Arg Ile Gly Ala Phe Asn Ile Gln Ser Phe 
            20                  25                  30          


Gly Asp Ser Lys Val Ser Asp Pro Ala Cys Gly Ser Ile Ile Ala Lys 
        35                  40                  45              


Ile Leu Ala Gly Tyr Asp Leu Ala Leu Val Gln Glu Val Arg Asp Pro 
    50                  55                  60                  


Asp Leu Ser Ala Val Ser Ala Leu Met Glu Gln Ile Asn Ser Val Ser 
65                  70                  75                  80  


Glu His Glu Tyr Ser Phe Val Ser Ser Gln Pro Leu Gly Arg Asp Gln 
                85                  90                  95      


Tyr Lys Glu Met Tyr Leu Phe Val Tyr Arg Lys Asp Ala Val Ser Val 
            100                 105                 110         


Val Asp Thr Tyr Leu Tyr Pro Asp Pro Glu Asp Val Phe Ser Arg Glu 
        115                 120                 125             


Pro Phe Val Val Lys Phe Ser Ala Pro Gly Thr Gly Glu Arg Ala Pro 
    130                 135                 140                 


Pro Leu Pro Ser Arg Arg Ala Leu Thr Pro Pro Pro Leu Pro Ala Ala 
145                 150                 155                 160 


Ala Gln Asn Leu Val Leu Ile Pro Leu His Ala Ala Pro His Gln Ala 
                165                 170                 175     


Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Ile Asp 
            180                 185                 190         


Lys Trp Gly Thr Asp Asp Met Leu Phe Leu Gly Asp Phe Asn Ala Asp 
        195                 200                 205             


Cys Ser Tyr Val Arg Ala Gln Asp Trp Ala Ala Ile Arg Leu Arg Ser 
    210                 215                 220                 


Ser Glu Val Phe Lys Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Val 
225                 230                 235                 240 


Gly Asn Ser Asp Cys Ala Tyr Asp Arg Ile Val Ala Cys Gly Ala Arg 
                245                 250                 255     


Leu Arg Arg Ser Leu Lys Pro Gln Ser Ala Thr Val His Asp Phe Gln 
            260                 265                 270         


Glu Glu Phe Gly Leu Asp Gln Thr Gln Ala Leu Ala Ile Ser Asp His 
        275                 280                 285             


Phe Pro Val Glu Val Thr Leu Lys Phe His Arg 
    290                 295                 


<210>  4393
<211>  254
<212>  PRT
<213>  Homo Sapiens

<400>  4393

Pro Arg Ala Leu Leu Ala Ala Leu Trp Ala Leu Glu Ala Ala Gly Thr 
1               5                   10                  15      


Ala Ala Leu Arg Ile Gly Ala Phe Asn Ile Gln Ser Phe Gly Asp Ser 
            20                  25                  30          


Lys Val Ser Asp Pro Ala Cys Gly Ser Ile Ile Ala Lys Ile Leu Ala 
        35                  40                  45              


Gly Tyr Asp Leu Ala Leu Val Gln Glu Val Arg Asp Pro Asp Leu Ser 
    50                  55                  60                  


Ala Val Ser Ala Leu Met Glu Gln Ile Asn Ser Val Ser Glu His Glu 
65                  70                  75                  80  


Tyr Ser Phe Val Ser Ser Gln Pro Leu Gly Arg Asp Gln Tyr Lys Glu 
                85                  90                  95      


Met Tyr Leu Phe Val Tyr Arg Lys Asp Ala Val Ser Val Val Asp Thr 
            100                 105                 110         


Tyr Leu Tyr Pro Asp Pro Glu Asp Val Phe Ser Arg Glu Pro Phe Val 
        115                 120                 125             


Val Lys Phe Ser Ala Pro Gly Thr Gly Glu Arg Ala Pro Pro Leu Pro 
    130                 135                 140                 


Ser Arg Arg Ala Leu Thr Pro Pro Pro Leu Pro Ala Ala Ala Gln Asn 
145                 150                 155                 160 


Leu Val Leu Ile Pro Leu His Ala Ala Pro His Gln Ala Val Ala Glu 
                165                 170                 175     


Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Ile Asp Lys Trp Gly 
            180                 185                 190         


Thr Asp Asp Trp Ala Ala Ile Arg Leu Arg Ser Ser Glu Val Phe Lys 
        195                 200                 205             


Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Val Gly Asn Ser Asp Cys 
    210                 215                 220                 


Ala Tyr Asp Arg Ile Val Ala Cys Gly Ala Arg Leu Arg Arg Ser Leu 
225                 230                 235                 240 


Lys Pro Gln Ser Ala Thr Val His Asp Phe Gln Glu Glu Phe 
                245                 250                 


<210>  4394
<211>  137
<212>  PRT
<213>  Homo Sapiens

<400>  4394

Ala Asp Val Phe Ser Arg Glu Pro Phe Val Val Trp Phe Gln Ser Pro 
1               5                   10                  15      


His Thr Ala Val Lys Asp Phe Val Ile Ile Pro Leu His Thr Thr Pro 
            20                  25                  30          


Glu Thr Ser Val Lys Glu Ile Asp Glu Leu Val Glu Val Tyr Thr Asp 
        35                  40                  45              


Val Lys His Arg Trp Lys Ala Glu Asn Phe Ile Phe Met Gly Asp Phe 
    50                  55                  60                  


Asn Ala Gly Cys Ser Tyr Val Pro Lys Lys Ala Trp Lys Asn Ile Arg 
65                  70                  75                  80  


Leu Arg Thr Asp Pro Arg Phe Val Trp Leu Ile Gly Asp Gln Glu Asp 
                85                  90                  95      


Thr Thr Val Lys Lys Ser Thr Asn Cys Ala Tyr Asp Arg Pro Trp Met 
            100                 105                 110         


Ser Ala Thr Thr Phe Gln Leu Asn Leu Asn Tyr Ser Leu Gln Gly Pro 
        115                 120                 125             


Ser Pro Thr Ala Lys Asn Leu Ser Leu 
    130                 135         


<210>  4395
<211>  275
<212>  PRT
<213>  Homo Sapiens

<400>  4395

Met Ser Arg Glu Leu Ala Pro Leu Leu Leu Leu Leu Leu Ser Ile His 
1               5                   10                  15      


Ser Ala Leu Ala Met Arg Ile Cys Ser Phe Asn Val Arg Ser Phe Gly 
            20                  25                  30          


Glu Ser Lys Gln Glu Asp Lys Asn Ala Met Asp Val Ile Val Lys Val 
        35                  40                  45              


Ile Lys Arg Cys Asp Ile Ile Leu Val Met Glu Ile Lys Asp Ser Asn 
    50                  55                  60                  


Asn Arg Ile Cys Pro Ile Leu Met Glu Lys Leu Asn Arg Glu Lys Leu 
65                  70                  75                  80  


Val Ser Val Lys Arg Ser Tyr His Tyr His Asp Tyr Gln Asp Gly Asp 
                85                  90                  95      


Ala Asp Val Phe Ser Arg Glu Pro Phe Val Val Trp Phe Gln Ser Pro 
            100                 105                 110         


His Thr Ala Val Lys Asp Phe Val Ile Ile Pro Leu His Thr Thr Pro 
        115                 120                 125             


Glu Thr Ser Val Lys Glu Ile Asp Glu Leu Val Glu Val Tyr Thr Asp 
    130                 135                 140                 


Val Lys His Arg Trp Lys Ala Glu Asn Phe Ile Phe Met Gly Asp Phe 
145                 150                 155                 160 


Asn Ala Gly Cys Ser Tyr Val Pro Lys Lys Ala Trp Lys Asn Ile Arg 
                165                 170                 175     


Leu Arg Thr Asp Pro Arg Phe Val Trp Leu Ile Gly Asp Gln Glu Asp 
            180                 185                 190         


Thr Thr Val Lys Lys Ser Thr Asn Cys Ala Tyr Asp Arg Ile Val Leu 
        195                 200                 205             


Arg Gly Gln Glu Ile Val Ser Ser Val Val Pro Lys Ser Asn Ser Val 
    210                 215                 220                 


Phe Asp Phe Gln Lys Ala Tyr Lys Leu Thr Glu Glu Glu Ala Leu Asp 
225                 230                 235                 240 


Val Ser Asp His Phe Pro Val Glu Phe Lys Leu Gln Ser Ser Arg Ala 
                245                 250                 255     


Phe Thr Asn Ser Lys Lys Ser Val Thr Leu Arg Lys Lys Thr Lys Ser 
            260                 265                 270         


Lys Arg Ser 
        275 


<210>  4396
<211>  100
<212>  PRT
<213>  Homo Sapiens

<400>  4396

Met Ser Arg Glu Leu Ala Pro Leu Leu Leu Leu Leu Leu Ser Ile His 
1               5                   10                  15      


Ser Ala Leu Ala Met Arg Ile Cys Ser Phe Asn Val Arg Ser Phe Gly 
            20                  25                  30          


Glu Ser Lys Gln Glu Asp Lys Asn Ala Met Asp Val Ile Val Lys Val 
        35                  40                  45              


Ile Lys Arg Cys Asp Ile Ile Leu Val Met Glu Ile Lys Asp Ser Asn 
    50                  55                  60                  


Asn Arg Ile Cys Pro Ile Leu Met Glu Lys Leu Asn Arg Asn Ser Arg 
65                  70                  75                  80  


Arg Gly Ile Thr Tyr Asn Tyr Val Ile Ser Ser Arg Leu Gly Arg Asn 
                85                  90                  95      


Thr Tyr Lys Glu 
            100 


<210>  4397
<211>  158
<212>  PRT
<213>  Homo Sapiens

<400>  4397

Met Ser Arg Glu Leu Ala Pro Leu Leu Leu Leu Leu Leu Ser Ile His 
1               5                   10                  15      


Ser Ala Leu Ala Met Arg Ile Cys Ser Phe Asn Val Arg Ser Phe Gly 
            20                  25                  30          


Glu Ser Lys Gln Glu Asp Lys Asn Ala Met Asp Val Ile Val Lys Val 
        35                  40                  45              


Ile Lys Arg Cys Asp Ile Ile Leu Val Met Glu Ile Lys Asp Ser Asn 
    50                  55                  60                  


Asn Arg Ile Cys Pro Ile Leu Met Glu Lys Leu Asn Arg Asn Ser Arg 
65                  70                  75                  80  


Arg Gly Ile Thr Tyr Asn Tyr Val Ile Ser Ser Arg Leu Gly Arg Asn 
                85                  90                  95      


Thr Tyr Lys Glu Gln Tyr Ala Phe Leu Tyr Lys Glu Lys Leu Val Ser 
            100                 105                 110         


Val Lys Arg Ser Tyr His Tyr His Asp Tyr Gln Asp Gly Asp Ala Asp 
        115                 120                 125             


Val Phe Ser Arg Glu Pro Phe Val Val Trp Phe Gln Ser Pro His Thr 
    130                 135                 140                 


Ala Val Lys Asp Phe Val Ile Ile Pro Leu His Thr Thr Pro 
145                 150                 155             


<210>  4398
<211>  305
<212>  PRT
<213>  Homo Sapiens

<400>  4398

Met Ser Arg Glu Leu Ala Pro Leu Leu Leu Leu Leu Leu Ser Ile His 
1               5                   10                  15      


Ser Ala Leu Ala Met Arg Ile Cys Ser Phe Asn Val Arg Ser Phe Gly 
            20                  25                  30          


Glu Ser Lys Gln Glu Asp Lys Asn Ala Met Asp Val Ile Val Lys Val 
        35                  40                  45              


Ile Lys Arg Cys Asp Ile Ile Leu Val Met Glu Ile Lys Asp Ser Asn 
    50                  55                  60                  


Asn Arg Ile Cys Pro Ile Leu Met Glu Lys Leu Asn Arg Asn Ser Arg 
65                  70                  75                  80  


Arg Gly Ile Thr Tyr Asn Tyr Val Ile Ser Ser Arg Leu Gly Arg Asn 
                85                  90                  95      


Thr Tyr Lys Glu Gln Tyr Ala Phe Leu Tyr Lys Glu Lys Leu Val Ser 
            100                 105                 110         


Val Lys Arg Ser Tyr His Tyr His Asp Tyr Gln Asp Gly Asp Ala Asp 
        115                 120                 125             


Val Phe Ser Arg Glu Pro Phe Val Val Trp Phe Gln Ser Pro His Thr 
    130                 135                 140                 


Ala Val Lys Asp Phe Val Ile Ile Pro Leu His Thr Thr Pro Glu Thr 
145                 150                 155                 160 


Ser Val Lys Glu Ile Asp Glu Leu Val Glu Val Tyr Thr Asp Val Lys 
                165                 170                 175     


His Arg Trp Lys Ala Glu Asn Phe Ile Phe Met Gly Asp Phe Asn Ala 
            180                 185                 190         


Gly Cys Ser Tyr Val Pro Lys Lys Ala Trp Lys Asn Ile Arg Leu Arg 
        195                 200                 205             


Thr Asp Pro Arg Phe Val Trp Leu Ile Gly Asp Gln Glu Asp Thr Thr 
    210                 215                 220                 


Val Lys Lys Ser Thr Asn Cys Ala Tyr Asp Arg Ile Val Leu Arg Gly 
225                 230                 235                 240 


Gln Glu Ile Val Ser Ser Val Val Pro Lys Ser Asn Ser Val Phe Asp 
                245                 250                 255     


Phe Gln Lys Ala Tyr Lys Leu Thr Glu Glu Glu Ala Leu Asp Val Ser 
            260                 265                 270         


Asp His Phe Pro Val Glu Phe Lys Leu Gln Ser Ser Arg Ala Phe Thr 
        275                 280                 285             


Asn Ser Lys Lys Ser Val Thr Leu Arg Lys Lys Thr Lys Ser Lys Arg 
    290                 295                 300                 


Ser 
305 


<210>  4399
<211>  288
<212>  PRT
<213>  Homo Sapiens

<400>  4399

Met Ser Arg Glu Leu Ala Pro Leu Leu Leu Leu Leu Leu Ser Ile His 
1               5                   10                  15      


Ser Ala Leu Ala Met Arg Ile Cys Ser Phe Asn Val Arg Ser Phe Gly 
            20                  25                  30          


Glu Ser Lys Gln Glu Asp Lys Asn Ala Met Asp Val Ile Val Lys Val 
        35                  40                  45              


Ile Lys Arg Cys Asp Ile Ile Leu Val Met Glu Ile Lys Asp Ser Asn 
    50                  55                  60                  


Asn Arg Ile Cys Pro Ile Leu Met Glu Lys Leu Asn Arg Asn Ser Arg 
65                  70                  75                  80  


Arg Gly Ile Thr Tyr Asn Tyr Val Ile Ser Ser Arg Leu Gly Arg Asn 
                85                  90                  95      


Thr Tyr Lys Glu Gln Tyr Ala Phe Leu Tyr Lys Glu Lys Leu Val Ser 
            100                 105                 110         


Val Lys Arg Ser Tyr His Tyr His Asp Tyr Gln Asp Gly Asp Ala Asp 
        115                 120                 125             


Val Phe Ser Arg Glu Pro Phe Val Val Trp Phe Gln Ser Pro His Thr 
    130                 135                 140                 


Ala Val Lys Asp Phe Val Ile Ile Pro Leu His Thr Thr Pro Glu Thr 
145                 150                 155                 160 


Ser Val Lys Glu Ile Asp Glu Leu Val Glu Val Tyr Thr Asp Val Lys 
                165                 170                 175     


His Arg Trp Lys Ala Glu Asn Phe Ile Phe Met Gly Asp Phe Asn Ala 
            180                 185                 190         


Gly Cys Ser Tyr Val Pro Lys Lys Ala Trp Lys Asn Ile Arg Leu Arg 
        195                 200                 205             


Thr Asp Pro Arg Phe Val Trp Leu Ile Gly Asp Gln Glu Asp Thr Thr 
    210                 215                 220                 


Val Lys Lys Ser Thr Asn Cys Ala Tyr Asp Arg Ile Val Leu Arg Gly 
225                 230                 235                 240 


Gln Glu Ile Val Ser Ser Val Val Pro Lys Ser Asn Ser Val Phe Asp 
                245                 250                 255     


Phe Gln Lys Ala Tyr Lys Leu Thr Glu Glu Glu Val Arg Leu Pro Ser 
            260                 265                 270         


Cys Leu Ser Met Pro Leu Ser Trp Lys Asp Glu Leu Ala Trp Ala Thr 
        275                 280                 285             


<210>  4400
<211>  218
<212>  PRT
<213>  Homo Sapiens

<400>  4400

Met Ile Pro Leu Leu Leu Ala Ala Leu Leu Cys Val Pro Ala Gly Ala 
1               5                   10                  15      


Leu Thr Cys Tyr Gly Asp Ser Gly Gln Pro Val Asp Trp Phe Val Val 
            20                  25                  30          


Tyr Lys Leu Pro Ala Leu Arg Gly Ser Gly Glu Ala Ala Gln Arg Gly 
        35                  40                  45              


Leu Gln Tyr Lys Tyr Leu Asp Glu Ser Ser Gly Gly Trp Arg Asp Gly 
    50                  55                  60                  


Arg Ala Leu Ile Asn Ser Pro Glu Gly Ala Val Gly Arg Ser Leu Gln 
65                  70                  75                  80  


Pro Leu Tyr Arg Ser Asn Thr Ser Gln Leu Ala Phe Leu Leu Tyr Asn 
                85                  90                  95      


Asp Gln Pro Pro Gln Pro Ser Lys Ala Gln Asp Ser Ser Met Arg Gly 
            100                 105                 110         


His Thr Lys Gly Lys Gln Leu Thr Tyr Thr Tyr Pro Trp Val Tyr Asn 
        115                 120                 125             


Tyr Gln Leu Glu Gly Ile Phe Ala Gln Glu Phe Pro Asp Leu Glu Asn 
    130                 135                 140                 


Val Val Lys Gly His His Val Ser Gln Glu Pro Trp Asn Ser Ser Ile 
145                 150                 155                 160 


Thr Leu Thr Ser Gln Ala Gly Ala Val Phe Gln Ser Phe Ala Lys Phe 
                165                 170                 175     


Ser Lys Phe Gly Asp Asp Leu Tyr Ser Gly Trp Leu Ala Ala Ala Leu 
            180                 185                 190         


Gly Thr Asn Leu Gln Val Gln Phe Trp His Lys Thr Val Gly Ile Leu 
        195                 200                 205             


Pro Ser Asn Cys Ser Asp Ile Trp Gln Val 
    210                 215             


<210>  4401
<211>  360
<212>  PRT
<213>  Homo Sapiens

<400>  4401

Met Ile Pro Leu Leu Leu Ala Ala Leu Leu Cys Val Pro Ala Gly Ala 
1               5                   10                  15      


Leu Thr Cys Tyr Gly Asp Ser Gly Gln Pro Val Asp Trp Phe Val Val 
            20                  25                  30          


Tyr Lys Leu Pro Ala Leu Arg Gly Ser Gly Glu Ala Ala Gln Arg Gly 
        35                  40                  45              


Leu Gln Tyr Lys Tyr Leu Asp Glu Ser Ser Gly Gly Trp Arg Asp Gly 
    50                  55                  60                  


Arg Ala Leu Ile Asn Ser Pro Glu Gly Ala Val Gly Arg Ser Leu Gln 
65                  70                  75                  80  


Pro Leu Tyr Arg Ser Asn Thr Ser Gln Leu Ala Phe Leu Leu Tyr Asn 
                85                  90                  95      


Asp Gln Pro Pro Gln Pro Ser Lys Ala Gln Asp Ser Ser Met Arg Gly 
            100                 105                 110         


His Thr Lys Gly Val Leu Leu Leu Asp His Asp Gly Gly Phe Trp Leu 
        115                 120                 125             


Val His Ser Val Pro Asn Phe Pro Pro Pro Ala Ser Ser Ala Ala Tyr 
    130                 135                 140                 


Ser Trp Pro His Ser Ala Cys Thr Tyr Gly Gln Thr Leu Leu Cys Val 
145                 150                 155                 160 


Ser Phe Pro Phe Ala Gln Phe Ser Lys Met Gly Lys Gln Leu Thr Tyr 
                165                 170                 175     


Thr Tyr Pro Trp Val Tyr Asn Tyr Gln Leu Glu Gly Ile Phe Ala Gln 
            180                 185                 190         


Glu Phe Pro Asp Leu Glu Asn Val Val Lys Gly His His Val Ser Gln 
        195                 200                 205             


Glu Pro Trp Asn Ser Ser Ile Thr Leu Thr Ser Gln Ala Gly Ala Val 
    210                 215                 220                 


Phe Gln Ser Phe Ala Lys Phe Ser Lys Phe Gly Asp Asp Leu Tyr Ser 
225                 230                 235                 240 


Gly Trp Leu Ala Ala Ala Leu Gly Thr Asn Leu Gln Val Gln Phe Trp 
                245                 250                 255     


His Lys Thr Val Gly Ile Leu Pro Ser Asn Cys Ser Asp Ile Trp Gln 
            260                 265                 270         


Val Leu Asn Val Asn Gln Ile Ala Phe Pro Gly Pro Ala Gly Pro Ser 
        275                 280                 285             


Phe Asn Ser Thr Glu Asp His Ser Lys Trp Cys Val Ser Pro Lys Gly 
    290                 295                 300                 


Pro Trp Thr Cys Val Gly Asp Met Asn Arg Asn Gln Gly Glu Glu Gln 
305                 310                 315                 320 


Arg Gly Gly Gly Thr Leu Cys Ala Gln Leu Pro Ala Leu Trp Lys Ala 
                325                 330                 335     


Phe Gln Pro Leu Val Lys Asn Tyr Gln Pro Cys Asn Gly Met Ala Arg 
            340                 345                 350         


Lys Pro Ser Arg Ala Tyr Lys Ile 
        355                 360 


<210>  4402
<211>  361
<212>  PRT
<213>  Homo Sapiens

<400>  4402

Met Lys Gln Lys Met Met Ala Arg Leu Leu Arg Thr Ser Phe Ala Leu 
1               5                   10                  15      


Leu Phe Leu Gly Leu Phe Gly Val Leu Gly Ala Ala Thr Ile Ser Cys 
            20                  25                  30          


Arg Asn Glu Glu Gly Lys Ala Val Asp Trp Phe Thr Phe Tyr Lys Leu 
        35                  40                  45              


Pro Lys Arg Gln Asn Lys Glu Ser Gly Glu Thr Gly Leu Glu Tyr Leu 
    50                  55                  60                  


Tyr Leu Asp Ser Thr Thr Arg Ser Trp Arg Lys Ser Glu Gln Leu Met 
65                  70                  75                  80  


Asn Asp Thr Lys Ser Val Leu Gly Arg Thr Leu Gln Gln Leu Tyr Glu 
                85                  90                  95      


Ala Tyr Ala Ser Lys Ser Asn Asn Thr Ala Tyr Leu Ile Tyr Asn Asp 
            100                 105                 110         


Gly Val Pro Lys Pro Val Asn Tyr Ser Arg Lys Tyr Gly His Thr Lys 
        115                 120                 125             


Gly Leu Leu Leu Trp Asn Arg Val Gln Gly Phe Trp Leu Ile His Ser 
    130                 135                 140                 


Ile Pro Gln Phe Pro Pro Ile Pro Glu Glu Gly Tyr Asp Tyr Pro Pro 
145                 150                 155                 160 


Thr Gly Arg Arg Asn Gly Gln Ser Gly Ile Cys Ile Thr Phe Lys Tyr 
                165                 170                 175     


Asn Gln Tyr Glu Ala Ile Asp Ser Gln Leu Leu Val Cys Asn Pro Asn 
            180                 185                 190         


Val Tyr Ser Cys Ser Ile Pro Ala Thr Phe His Gln Glu Leu Ile His 
        195                 200                 205             


Met Pro Gln Leu Cys Thr Arg Ala Ser Ser Ser Glu Ile Pro Gly Arg 
    210                 215                 220                 


Leu Leu Thr Thr Leu Gln Ser Ala Gln Gly Gln Lys Phe Leu His Phe 
225                 230                 235                 240 


Ala Lys Ser Asp Ser Phe Leu Asp Asp Ile Phe Ala Ala Trp Met Ala 
                245                 250                 255     


Gln Arg Leu Lys Thr His Leu Leu Thr Glu Thr Trp Gln Arg Lys Arg 
            260                 265                 270         


Gln Glu Leu Pro Ser Asn Cys Ser Leu Pro Tyr His Val Tyr Asn Ile 
        275                 280                 285             


Lys Ala Ile Lys Leu Ser Arg His Ser Tyr Phe Ser Ser Tyr Gln Asp 
    290                 295                 300                 


His Ala Lys Trp Cys Ile Ser Gln Lys Gly Thr Lys Asn Arg Trp Thr 
305                 310                 315                 320 


Cys Ile Gly Asp Leu Asn Arg Ser Pro His Gln Ala Phe Arg Ser Gly 
                325                 330                 335     


Gly Phe Ile Cys Thr Gln Asn Trp Gln Ile Tyr Gln Ala Phe Gln Gly 
            340                 345                 350         


Leu Val Leu Tyr Tyr Glu Ser Cys Lys 
        355                 360     


<210>  4403
<211>  153
<212>  PRT
<213>  Homo Sapiens

<400>  4403

Met Pro Gln Leu Cys Thr Arg Ala Ser Ser Ser Glu Ile Pro Gly Arg 
1               5                   10                  15      


Leu Leu Thr Thr Leu Gln Ser Ala Gln Gly Gln Lys Phe Leu His Phe 
            20                  25                  30          


Ala Lys Ser Asp Ser Phe Leu Asp Asp Ile Phe Ala Ala Trp Met Ala 
        35                  40                  45              


Gln Arg Leu Lys Thr His Leu Leu Thr Glu Thr Trp Gln Arg Lys Arg 
    50                  55                  60                  


Gln Glu Leu Pro Ser Asn Cys Ser Leu Pro Tyr His Val Tyr Asn Ile 
65                  70                  75                  80  


Lys Ala Ile Lys Leu Ser Arg His Ser Tyr Phe Ser Ser Tyr Gln Asp 
                85                  90                  95      


His Ala Lys Trp Cys Ile Ser Gln Lys Gly Thr Lys Asn Arg Trp Thr 
            100                 105                 110         


Cys Ile Gly Asp Leu Asn Arg Ser Pro His Gln Ala Phe Arg Ser Gly 
        115                 120                 125             


Gly Phe Ile Cys Thr Gln Asn Trp Gln Ile Tyr Gln Ala Phe Gln Gly 
    130                 135                 140                 


Leu Val Leu Tyr Tyr Glu Ser Cys Lys 
145                 150             


<210>  4404
<211>  107
<212>  PRT
<213>  Homo Sapiens

<400>  4404

Met Trp Ser Gly Trp Trp Leu Trp Pro Leu Val Ala Val Cys Thr Ala 
1               5                   10                  15      


Asp Phe Phe Arg Asp Glu Ala Glu Arg Ile Met Arg Asp Ser Pro Val 
            20                  25                  30          


Ile Asp Gly His Asn Asp Leu Pro Trp Gln Leu Leu Asp Met Phe Asn 
        35                  40                  45              


Asn Arg Leu Gln Asp Glu Arg Ala Asn Leu Thr Thr Leu Ala Gly Thr 
    50                  55                  60                  


His Thr Asn Ile Pro Lys Leu Arg Ala Gly Phe Val Gly Gly Gln Phe 
65                  70                  75                  80  


Trp Ser Val Tyr Thr Pro Cys Asp Thr Gln Asn Lys Asp Ala Val Arg 
                85                  90                  95      


Arg Thr Leu Glu Gln Met Asp Val Val His Arg 
            100                 105         


<210>  4405
<211>  111
<212>  PRT
<213>  Homo Sapiens

<400>  4405

Met Trp Ser Gly Trp Trp Leu Trp Pro Leu Val Ala Val Cys Thr Ala 
1               5                   10                  15      


Asp Phe Phe Arg Asp Glu Ala Glu Arg Ile Met Arg Asp Ser Pro Val 
            20                  25                  30          


Ile Asp Gly His Asn Asp Leu Pro Trp Gln Leu Leu Asp Met Phe Asn 
        35                  40                  45              


Asn Arg Leu Gln Asp Glu Arg Ala Asn Leu Thr Thr Leu Ala Gly Thr 
    50                  55                  60                  


His Thr Asn Ile Pro Lys Leu Arg Ala Gly Phe Val Gly Gly Gln Phe 
65                  70                  75                  80  


Trp Ser Val Tyr Thr Pro Cys Asp Thr Gln Asn Lys Asp Ala Val Arg 
                85                  90                  95      


Arg Thr Leu Glu Gln Met Asp Val Val His Arg Met Cys Arg Met 
            100                 105                 110     


<210>  4406
<211>  411
<212>  PRT
<213>  Homo Sapiens

<400>  4406

Met Trp Ser Gly Trp Trp Leu Trp Pro Leu Val Ala Val Cys Thr Ala 
1               5                   10                  15      


Asp Phe Phe Arg Asp Glu Ala Glu Arg Ile Met Arg Asp Ser Pro Val 
            20                  25                  30          


Ile Asp Gly His Asn Asp Leu Pro Trp Gln Leu Leu Asp Met Phe Asn 
        35                  40                  45              


Asn Arg Leu Gln Asp Glu Arg Ala Asn Leu Thr Thr Leu Ala Gly Thr 
    50                  55                  60                  


His Thr Asn Ile Pro Lys Leu Arg Ala Gly Phe Val Gly Gly Gln Phe 
65                  70                  75                  80  


Trp Ser Val Tyr Thr Pro Cys Asp Thr Gln Asn Lys Asp Ala Val Arg 
                85                  90                  95      


Arg Thr Leu Glu Gln Met Asp Val Val His Arg Met Cys Arg Met Tyr 
            100                 105                 110         


Pro Glu Thr Phe Leu Tyr Val Thr Ser Ser Ala Gly Ile Arg Gln Ala 
        115                 120                 125             


Phe Arg Glu Gly Lys Val Ala Ser Leu Ile Gly Val Glu Gly Gly His 
    130                 135                 140                 


Ser Ile Asp Ser Ser Leu Gly Val Leu Arg Ala Leu Tyr Gln Leu Gly 
145                 150                 155                 160 


Met Arg Tyr Leu Thr Leu Thr His Ser Cys Asn Thr Pro Trp Ala Asp 
                165                 170                 175     


Asn Trp Leu Val Asp Thr Gly Asp Ser Glu Pro Gln Ser Gln Gly Leu 
            180                 185                 190         


Ser Pro Phe Gly Gln Arg Val Val Lys Glu Leu Asn Arg Leu Gly Val 
        195                 200                 205             


Leu Ile Asp Leu Ala His Val Ser Val Ala Thr Met Lys Ala Thr Leu 
    210                 215                 220                 


Gln Leu Ser Arg Ala Pro Val Ile Phe Ser His Ser Ser Ala Tyr Ser 
225                 230                 235                 240 


Val Cys Ala Ser Arg Arg Asn Val Pro Asp Asp Val Leu Arg Leu Val 
                245                 250                 255     


Lys Gln Thr Asp Ser Leu Val Met Val Asn Phe Tyr Asn Asn Tyr Ile 
            260                 265                 270         


Ser Cys Thr Asn Lys Ala Asn Leu Ser Gln Val Ala Asp His Leu Asp 
        275                 280                 285             


His Ile Lys Glu Val Ala Gly Ala Arg Ala Val Gly Phe Gly Gly Asp 
    290                 295                 300                 


Phe Asp Gly Val Pro Arg Val Pro Glu Gly Leu Glu Asp Val Ser Lys 
305                 310                 315                 320 


Tyr Pro Asp Leu Ile Ala Glu Leu Leu Arg Arg Asn Trp Thr Glu Ala 
                325                 330                 335     


Glu Val Lys Gly Ala Leu Ala Asp Asn Leu Leu Arg Val Phe Glu Ala 
            340                 345                 350         


Val Glu Gln Ala Ser Asn Leu Thr Gln Ala Pro Glu Glu Glu Pro Ile 
        355                 360                 365             


Pro Leu Asp Gln Leu Gly Gly Ser Cys Arg Thr His Tyr Gly Tyr Ser 
    370                 375                 380                 


Ser Gly Ala Ser Ser Leu His Arg His Trp Gly Leu Leu Leu Ala Ser 
385                 390                 395                 400 


Leu Ala Pro Leu Val Leu Cys Leu Ser Leu Leu 
                405                 410     


<210>  4407
<211>  411
<212>  PRT
<213>  Homo Sapiens

<400>  4407

Met Trp Ser Gly Trp Trp Leu Trp Pro Leu Val Ala Val Cys Thr Ala 
1               5                   10                  15      


Asp Phe Phe Arg Asp Glu Ala Glu Arg Ile Met Arg Asp Ser Pro Val 
            20                  25                  30          


Ile Asp Gly His Asn Asp Leu Pro Trp Gln Leu Leu Asp Met Phe Asn 
        35                  40                  45              


Asn Arg Leu Gln Asp Glu Arg Ala Asn Leu Thr Thr Leu Ala Gly Thr 
    50                  55                  60                  


His Thr Asn Ile Pro Lys Leu Arg Ala Gly Phe Val Gly Gly Gln Phe 
65                  70                  75                  80  


Trp Ser Val Tyr Thr Pro Cys Asp Thr Gln Asn Lys Asp Ala Val Arg 
                85                  90                  95      


Arg Thr Leu Glu Gln Met Asp Val Val His Arg Met Cys Arg Met Tyr 
            100                 105                 110         


Pro Glu Thr Phe Leu Tyr Val Thr Ser Ser Ala Gly Ile Arg Gln Ala 
        115                 120                 125             


Phe Arg Glu Gly Lys Val Ala Ser Leu Ile Gly Val Glu Gly Gly His 
    130                 135                 140                 


Ser Ile Asp Ser Ser Leu Gly Val Leu Arg Ala Leu Tyr Gln Leu Gly 
145                 150                 155                 160 


Met Arg Tyr Leu Thr Leu Thr His Ser Cys Asn Thr Pro Trp Ala Asp 
                165                 170                 175     


Asn Trp Leu Val Asp Thr Gly Asp Ser Glu Pro Gln Ser Gln Gly Leu 
            180                 185                 190         


Ser Pro Phe Gly Gln Arg Val Val Lys Glu Leu Asn Arg Leu Gly Val 
        195                 200                 205             


Leu Ile Asp Leu Ala His Val Ser Val Ala Thr Met Lys Ala Thr Leu 
    210                 215                 220                 


Gln Leu Ser Arg Ala Pro Val Ile Phe Ser His Ser Ser Ala Tyr Ser 
225                 230                 235                 240 


Val Cys Ala Ser Arg Arg Asn Val Pro Asp Asp Val Leu Arg Leu Val 
                245                 250                 255     


Lys Gln Thr Asp Ser Leu Val Met Val Asn Phe Tyr Asn Asn Tyr Ile 
            260                 265                 270         


Ser Cys Thr Asn Lys Ala Asn Leu Ser Gln Val Ala Asp His Leu Asp 
        275                 280                 285             


His Ile Lys Glu Val Ala Gly Ala Arg Ala Val Gly Phe Gly Gly Asp 
    290                 295                 300                 


Phe Asp Gly Val Pro Arg Val Pro Glu Gly Leu Glu Asp Val Ser Lys 
305                 310                 315                 320 


Tyr Pro Asp Leu Ile Ala Glu Leu Leu Arg Arg Asn Trp Thr Glu Ala 
                325                 330                 335     


Glu Val Lys Gly Ala Leu Ala Asp Asn Leu Leu Arg Val Phe Glu Ala 
            340                 345                 350         


Val Glu Gln Ala Ser Asn Leu Thr Gln Ala Pro Glu Glu Glu Pro Ile 
        355                 360                 365             


Pro Leu Asp Gln Leu Gly Gly Ser Cys Arg Thr His Tyr Gly Tyr Ser 
    370                 375                 380                 


Ser Gly Ala Ser Ser Leu His Arg His Trp Gly Leu Leu Leu Ala Ser 
385                 390                 395                 400 


Leu Ala Pro Leu Val Leu Cys Leu Ser Leu Leu 
                405                 410     


<210>  4408
<211>  411
<212>  PRT
<213>  Homo Sapiens

<400>  4408

Met Trp Ser Gly Trp Trp Leu Trp Pro Leu Val Ala Val Cys Thr Ala 
1               5                   10                  15      


Asp Phe Phe Arg Asp Glu Ala Glu Arg Ile Met Arg Asp Ser Pro Val 
            20                  25                  30          


Ile Asp Gly His Asn Asp Leu Pro Trp Gln Leu Leu Asp Met Phe Asn 
        35                  40                  45              


Asn Arg Leu Gln Asp Glu Arg Ala Asn Leu Thr Thr Leu Ala Gly Thr 
    50                  55                  60                  


His Thr Asn Ile Pro Lys Leu Arg Ala Gly Phe Val Gly Gly Gln Phe 
65                  70                  75                  80  


Trp Ser Val Tyr Thr Pro Cys Asp Thr Gln Asn Lys Asp Ala Val Arg 
                85                  90                  95      


Arg Thr Leu Glu Gln Met Asp Val Val His Arg Met Cys Arg Met Tyr 
            100                 105                 110         


Pro Glu Thr Phe Leu Tyr Val Thr Ser Ser Ala Gly Ile Arg Gln Ala 
        115                 120                 125             


Phe Arg Glu Gly Lys Val Ala Ser Leu Ile Gly Val Glu Gly Gly His 
    130                 135                 140                 


Ser Ile Asp Ser Ser Leu Gly Val Leu Arg Ala Leu Tyr Gln Leu Gly 
145                 150                 155                 160 


Met Arg Tyr Leu Thr Leu Thr His Ser Cys Asn Thr Pro Trp Ala Asp 
                165                 170                 175     


Asn Trp Leu Val Asp Thr Gly Asp Ser Glu Pro Gln Ser Gln Gly Leu 
            180                 185                 190         


Ser Pro Phe Gly Gln Arg Val Val Lys Glu Leu Asn Arg Leu Gly Val 
        195                 200                 205             


Leu Ile Asp Leu Ala His Val Ser Val Ala Thr Met Lys Ala Thr Leu 
    210                 215                 220                 


Gln Leu Ser Arg Ala Pro Val Ile Phe Ser His Ser Ser Ala Tyr Ser 
225                 230                 235                 240 


Val Cys Ala Ser Arg Arg Asn Val Pro Asp Asp Val Leu Arg Leu Val 
                245                 250                 255     


Lys Gln Thr Asp Ser Leu Val Met Val Asn Phe Tyr Asn Asn Tyr Ile 
            260                 265                 270         


Ser Cys Thr Asn Lys Ala Asn Leu Ser Gln Val Ala Asp His Leu Asp 
        275                 280                 285             


His Ile Lys Glu Val Ala Gly Ala Arg Ala Val Gly Phe Gly Gly Asp 
    290                 295                 300                 


Phe Asp Gly Val Pro Arg Val Pro Glu Gly Leu Glu Asp Val Ser Lys 
305                 310                 315                 320 


Tyr Pro Asp Leu Ile Ala Glu Leu Leu Arg Arg Asn Trp Thr Glu Ala 
                325                 330                 335     


Glu Val Lys Gly Ala Leu Ala Asp Asn Leu Leu Arg Val Phe Glu Ala 
            340                 345                 350         


Val Glu Gln Ala Ser Asn Leu Thr Gln Ala Pro Glu Glu Glu Pro Ile 
        355                 360                 365             


Pro Leu Asp Gln Leu Gly Gly Ser Cys Arg Thr His Tyr Gly Tyr Ser 
    370                 375                 380                 


Ser Gly Ala Ser Ser Leu His Arg His Trp Gly Leu Leu Leu Ala Ser 
385                 390                 395                 400 


Leu Ala Pro Leu Val Leu Cys Leu Ser Leu Leu 
                405                 410     


<210>  4409
<211>  161
<212>  PRT
<213>  Homo Sapiens

<400>  4409

Met Lys Leu Gln Thr Leu Ala Val Ser Val Thr Ala Leu Lys Phe Trp 
1               5                   10                  15      


Ser Ala Tyr Val Pro Cys Gln Thr Gln Asp Arg Asp Ala Leu Arg Leu 
            20                  25                  30          


Thr Leu Glu Gln Ile Asp Leu Ile Arg Arg Met Cys Ala Ser Tyr Ser 
        35                  40                  45              


Glu Leu Glu Leu Val Thr Ser Ala Lys Ala Leu Asn Asp Thr Gln Lys 
    50                  55                  60                  


Leu Ala Cys Leu Ile Gly Val Glu Gly Gly His Ser Leu Asp Asn Ser 
65                  70                  75                  80  


Leu Ser Ile Leu Arg Thr Phe Tyr Met Leu Gly Val Arg Tyr Leu Thr 
                85                  90                  95      


Leu Thr His Thr Cys Asn Thr Pro Trp Ala Glu Ser Ser Ala Lys Gly 
            100                 105                 110         


Val His Ser Phe Tyr Asn Asn Ile Ser Gly Leu Thr Asp Phe Gly Glu 
        115                 120                 125             


Lys Val Val Ala Glu Met Asn Arg Leu Gly Met Met Val Asp Leu Ser 
    130                 135                 140                 


His Val Ser Asp Ala Val Ala Arg Arg Ala Leu Glu Val Ser Gln Ala 
145                 150                 155                 160 


Pro 
    


<210>  4410
<211>  123
<212>  PRT
<213>  Homo Sapiens

<400>  4410

Met Gln Met Ile Ile Ile Trp Ala Leu Leu Asp Thr Glu Ala Glu Ser 
1               5                   10                  15      


Ser Ala Lys Gly Val His Ser Phe Tyr Asn Asn Ile Ser Gly Leu Thr 
            20                  25                  30          


Asp Phe Gly Glu Lys Val Val Ala Glu Met Asn Arg Leu Gly Met Met 
        35                  40                  45              


Val Asp Leu Ser His Val Ser Asp Ala Val Ala Arg Arg Ala Leu Glu 
    50                  55                  60                  


Val Ser Gln Ala Pro Val Ile Phe Ser His Ser Ala Ala Arg Gly Val 
65                  70                  75                  80  


Cys Asn Ser Ala Arg Asn Val Pro Asp Asp Ile Leu Gln Leu Leu Lys 
                85                  90                  95      


Lys Asn Gly Gly Val Val Met Val Ser Leu Ser Met Gly Val Ile Gln 
            100                 105                 110         


Cys Asn Pro Ser Ala Asn Val Ser Thr Val Ala 
        115                 120             


<210>  4411
<211>  114
<212>  PRT
<213>  Homo Sapiens

<400>  4411

Met Gln Pro Ser Gly Leu Glu Gly Pro Gly Thr Phe Gly Arg Trp Pro 
1               5                   10                  15      


Leu Leu Ser Leu Leu Leu Leu Leu Leu Leu Leu Gln Pro Val Thr Cys 
            20                  25                  30          


Ala Tyr Thr Thr Pro Gly Pro Pro Arg Ala Leu Thr Thr Leu Gly Ala 
        35                  40                  45              


Pro Arg Ala His Thr Met Pro Gly Thr Tyr Ala Pro Ser Thr Thr Leu 
    50                  55                  60                  


Ser Ser Pro Ser Thr Gln Gly Leu Gln Glu Gln Ala Arg Ala Leu Met 
65                  70                  75                  80  


Arg Asp Phe Pro Leu Val Asp Gly His Asn Asp Leu Pro Leu Val Leu 
                85                  90                  95      


Arg Gln Val Tyr Gln Lys Gly Leu Gln Asp Val Asn Leu Arg Asn Phe 
            100                 105                 110         


Ser Tyr 
        


<210>  4412
<211>  137
<212>  PRT
<213>  Homo Sapiens

<400>  4412

Met Gln Pro Ser Gly Leu Glu Gly Pro Gly Thr Phe Gly Arg Trp Pro 
1               5                   10                  15      


Leu Leu Ser Leu Leu Leu Leu Leu Leu Leu Leu Gln Pro Val Thr Cys 
            20                  25                  30          


Ala Tyr Thr Thr Pro Gly Pro Pro Arg Ala Leu Thr Thr Leu Gly Ala 
        35                  40                  45              


Pro Arg Ala His Thr Met Pro Gly Thr Tyr Ala Pro Ser Thr Thr Leu 
    50                  55                  60                  


Ser Ser Pro Ser Thr Gln Gly Leu Gln Glu Gln Ala Arg Ala Leu Met 
65                  70                  75                  80  


Arg Asp Phe Pro Leu Val Asp Gly His Asn Asp Leu Pro Leu Val Leu 
                85                  90                  95      


Arg Gln Val Tyr Gln Lys Gly Leu Gln Asp Val Asn Leu Arg Asn Phe 
            100                 105                 110         


Ser Tyr Gly Gln Thr Ser Leu Asp Arg Leu Arg Asp Gly Leu Val Gly 
        115                 120                 125             


Ala Gln Phe Trp Ser Ala Tyr Val Pro 
    130                 135         


<210>  4413
<211>  486
<212>  PRT
<213>  Homo Sapiens

<400>  4413

Met Gln Pro Ser Gly Leu Glu Gly Pro Gly Thr Phe Gly Arg Trp Pro 
1               5                   10                  15      


Leu Leu Ser Leu Leu Leu Leu Leu Leu Leu Leu Gln Pro Val Thr Cys 
            20                  25                  30          


Ala Tyr Thr Thr Pro Gly Pro Pro Arg Ala Leu Thr Thr Leu Gly Ala 
        35                  40                  45              


Pro Arg Ala His Thr Met Pro Gly Thr Tyr Ala Pro Ser Thr Thr Leu 
    50                  55                  60                  


Ser Ser Pro Ser Thr Gln Gly Leu Gln Glu Gln Ala Arg Ala Leu Met 
65                  70                  75                  80  


Arg Asp Phe Pro Leu Val Asp Gly His Asn Asp Leu Pro Leu Val Leu 
                85                  90                  95      


Arg Gln Val Tyr Gln Lys Gly Leu Gln Asp Val Asn Leu Arg Asn Phe 
            100                 105                 110         


Ser Tyr Gly Gln Thr Ser Leu Asp Arg Leu Arg Asp Gly Leu Val Gly 
        115                 120                 125             


Ala Gln Phe Trp Ser Ala Tyr Val Pro Cys Gln Thr Gln Asp Arg Asp 
    130                 135                 140                 


Ala Leu Arg Leu Thr Leu Glu Gln Ile Asp Leu Ile Arg Arg Met Cys 
145                 150                 155                 160 


Ala Ser Tyr Ser Glu Leu Glu Leu Val Thr Ser Ala Lys Ala Leu Asn 
                165                 170                 175     


Asp Thr Gln Lys Leu Ala Cys Leu Ile Gly Val Glu Gly Gly His Ser 
            180                 185                 190         


Leu Asp Asn Ser Leu Ser Ile Leu Arg Thr Phe Tyr Met Leu Gly Val 
        195                 200                 205             


Arg Tyr Leu Thr Leu Thr His Thr Cys Asn Thr Pro Trp Ala Glu Ser 
    210                 215                 220                 


Ser Ala Lys Gly Val His Ser Phe Tyr Asn Asn Ile Ser Gly Leu Thr 
225                 230                 235                 240 


Asp Phe Gly Glu Lys Val Val Ala Glu Met Asn Arg Leu Gly Met Met 
                245                 250                 255     


Val Asp Leu Ser His Val Ser Asp Ala Val Ala Arg Arg Ala Leu Glu 
            260                 265                 270         


Val Ser Gln Ala Pro Val Ile Phe Ser His Ser Ala Ala Arg Gly Val 
        275                 280                 285             


Cys Asn Ser Ala Arg Asn Val Pro Asp Asp Ile Leu Gln Leu Leu Lys 
    290                 295                 300                 


Lys Asn Gly Gly Val Val Met Val Ser Leu Ser Met Gly Val Ile Gln 
305                 310                 315                 320 


Cys Asn Pro Ser Ala Asn Val Ser Thr Val Ala Asp His Phe Asp His 
                325                 330                 335     


Ile Lys Ala Val Ile Gly Ser Lys Phe Ile Gly Ile Gly Gly Asp Tyr 
            340                 345                 350         


Asp Gly Ala Gly Lys Phe Pro Gln Gly Leu Glu Asp Val Ser Thr Tyr 
        355                 360                 365             


Pro Val Leu Ile Glu Glu Leu Leu Ser Arg Gly Trp Ser Glu Glu Glu 
    370                 375                 380                 


Leu Gln Gly Val Leu Arg Gly Asn Leu Leu Arg Val Phe Arg Gln Val 
385                 390                 395                 400 


Glu Lys Val Gln Glu Glu Asn Lys Trp Gln Ser Pro Leu Glu Asp Lys 
                405                 410                 415     


Phe Pro Asp Glu Gln Leu Ser Ser Ser Cys His Ser Asp Leu Ser Arg 
            420                 425                 430         


Leu Arg Gln Arg Gln Ser Leu Thr Ser Gly Gln Glu Leu Thr Glu Ile 
        435                 440                 445             


Pro Ile His Trp Thr Ala Lys Leu Pro Ala Lys Trp Ser Val Ser Glu 
    450                 455                 460                 


Ser Ser Pro His Met Ala Pro Val Leu Ala Val Val Ala Thr Phe Pro 
465                 470                 475                 480 


Val Leu Ile Leu Trp Leu 
                485     


<210>  4414
<211>  486
<212>  PRT
<213>  Homo Sapiens

<400>  4414

Met Gln Pro Ser Gly Leu Glu Gly Pro Gly Thr Phe Gly Arg Trp Pro 
1               5                   10                  15      


Leu Leu Ser Leu Leu Leu Leu Leu Leu Leu Leu Gln Pro Val Thr Cys 
            20                  25                  30          


Ala Tyr Thr Thr Pro Gly Pro Pro Arg Ala Leu Thr Thr Leu Gly Ala 
        35                  40                  45              


Pro Arg Ala His Thr Met Pro Gly Thr Tyr Ala Pro Ser Thr Thr Leu 
    50                  55                  60                  


Ser Ser Pro Ser Thr Gln Gly Leu Gln Glu Gln Ala Arg Ala Leu Met 
65                  70                  75                  80  


Arg Asp Phe Pro Leu Val Asp Gly His Asn Asp Leu Pro Leu Val Leu 
                85                  90                  95      


Arg Gln Val Tyr Gln Lys Gly Leu Gln Asp Val Asn Leu Arg Asn Phe 
            100                 105                 110         


Ser Tyr Gly Gln Thr Ser Leu Asp Arg Leu Arg Asp Gly Leu Val Gly 
        115                 120                 125             


Ala Gln Phe Trp Ser Ala Tyr Val Pro Cys Gln Thr Gln Asp Arg Asp 
    130                 135                 140                 


Ala Leu Arg Leu Thr Leu Glu Gln Ile Asp Leu Ile Arg Arg Met Cys 
145                 150                 155                 160 


Ala Ser Tyr Ser Glu Leu Glu Leu Val Thr Ser Ala Lys Ala Leu Asn 
                165                 170                 175     


Asp Thr Gln Lys Leu Ala Cys Leu Ile Gly Val Glu Gly Gly His Ser 
            180                 185                 190         


Leu Asp Asn Ser Leu Ser Ile Leu Arg Thr Phe Tyr Met Leu Gly Val 
        195                 200                 205             


Arg Tyr Leu Thr Leu Thr His Thr Cys Asn Thr Pro Trp Ala Glu Ser 
    210                 215                 220                 


Ser Ala Lys Gly Val His Ser Phe Tyr Asn Asn Ile Ser Gly Leu Thr 
225                 230                 235                 240 


Asp Phe Gly Glu Lys Val Val Ala Glu Met Asn Arg Leu Gly Met Met 
                245                 250                 255     


Val Asp Leu Ser His Val Ser Asp Ala Val Ala Arg Arg Ala Leu Glu 
            260                 265                 270         


Val Ser Gln Ala Pro Val Ile Phe Ser His Ser Ala Ala Arg Gly Val 
        275                 280                 285             


Cys Asn Ser Ala Arg Asn Val Pro Asp Asp Ile Leu Gln Leu Leu Lys 
    290                 295                 300                 


Lys Asn Gly Gly Val Val Met Val Ser Leu Ser Met Gly Val Ile Gln 
305                 310                 315                 320 


Cys Asn Pro Ser Ala Asn Val Ser Thr Val Ala Asp His Phe Asp His 
                325                 330                 335     


Ile Lys Ala Val Ile Gly Ser Lys Phe Ile Gly Ile Gly Gly Asp Tyr 
            340                 345                 350         


Asp Gly Ala Gly Lys Phe Pro Gln Gly Leu Glu Asp Val Ser Thr Tyr 
        355                 360                 365             


Pro Val Leu Ile Glu Glu Leu Leu Ser Arg Gly Trp Ser Glu Glu Glu 
    370                 375                 380                 


Leu Gln Gly Val Leu Arg Gly Asn Leu Leu Arg Val Phe Arg Gln Val 
385                 390                 395                 400 


Glu Lys Val Gln Glu Glu Asn Lys Trp Gln Ser Pro Leu Glu Asp Lys 
                405                 410                 415     


Phe Pro Asp Glu Gln Leu Ser Ser Ser Cys His Ser Asp Leu Ser Arg 
            420                 425                 430         


Leu Arg Gln Arg Gln Ser Leu Thr Ser Gly Gln Glu Leu Thr Glu Ile 
        435                 440                 445             


Pro Ile His Trp Thr Ala Lys Leu Pro Ala Lys Trp Ser Val Ser Glu 
    450                 455                 460                 


Ser Ser Pro His Met Ala Pro Val Leu Ala Val Val Ala Thr Phe Pro 
465                 470                 475                 480 


Val Leu Ile Leu Trp Leu 
                485     


<210>  4415
<211>  258
<212>  PRT
<213>  Homo Sapiens

<400>  4415

Met Gln Pro Ser Gly Leu Glu Gly Pro Gly Thr Phe Gly Arg Trp Pro 
1               5                   10                  15      


Leu Leu Ser Leu Leu Leu Leu Leu Leu Leu Leu Gln Pro Val Thr Cys 
            20                  25                  30          


Ala Tyr Thr Thr Pro Gly Pro Pro Arg Ala Leu Thr Thr Leu Gly Ala 
        35                  40                  45              


Pro Arg Ala His Thr Met Pro Gly Thr Tyr Ala Pro Ser Thr Thr Leu 
    50                  55                  60                  


Ser Ser Pro Ser Thr Gln Gly Leu Gln Glu Gln Ala Arg Ala Leu Met 
65                  70                  75                  80  


Arg Asp Phe Pro Leu Val Asp Gly His Asn Asp Leu Pro Leu Val Leu 
                85                  90                  95      


Arg Gln Val Tyr Gln Lys Gly Leu Gln Asp Val Asn Leu Arg Asn Phe 
            100                 105                 110         


Ser Tyr Gly Gln Thr Ser Leu Asp Arg Leu Arg Asp Gly Leu Val Gly 
        115                 120                 125             


Ala Gln Phe Trp Ser Ala Tyr Val Pro Cys Gln Thr Gln Asp Arg Asp 
    130                 135                 140                 


Ala Leu Arg Leu Thr Leu Glu Gln Ile Asp Leu Ile Arg Arg Met Cys 
145                 150                 155                 160 


Ala Ser Tyr Ser Glu Leu Glu Leu Val Thr Ser Ala Lys Ala Leu Asn 
                165                 170                 175     


Asp Thr Gln Lys Leu Ala Cys Leu Ile Gly Val Glu Gly Gly His Ser 
            180                 185                 190         


Leu Asp Asn Ser Leu Ser Ile Leu Arg Thr Phe Tyr Met Leu Gly Val 
        195                 200                 205             


Arg Tyr Leu Thr Leu Thr His Thr Cys Asn Thr Pro Trp Ala Glu Ser 
    210                 215                 220                 


Ser Ala Lys Gly Val His Ser Phe Tyr Asn Asn Ile Ser Gly Leu Thr 
225                 230                 235                 240 


Asp Phe Gly Glu Met Leu Trp His Gly Gly Pro Trp Lys Cys His Arg 
                245                 250                 255     


His Leu 
        


<210>  4416
<211>  513
<212>  PRT
<213>  Homo Sapiens

<400>  4416

Met Ile Arg Thr Pro Leu Ser Ala Ser Ala His Arg Leu Leu Leu Pro 
1               5                   10                  15      


Gly Ser Arg Gly Arg Pro Pro Arg Asn Met Gln Pro Thr Gly Arg Glu 
            20                  25                  30          


Gly Ser Arg Ala Leu Ser Arg Arg Tyr Leu Arg Arg Leu Leu Leu Leu 
        35                  40                  45              


Leu Leu Leu Leu Leu Leu Arg Gln Pro Val Thr Arg Ala Glu Thr Thr 
    50                  55                  60                  


Pro Gly Ala Pro Arg Ala Leu Ser Thr Leu Gly Ser Pro Ser Leu Phe 
65                  70                  75                  80  


Thr Thr Pro Gly Val Pro Ser Ala Leu Thr Thr Pro Gly Leu Thr Thr 
                85                  90                  95      


Pro Gly Thr Pro Lys Thr Leu Asp Leu Arg Gly Arg Ala Gln Ala Leu 
            100                 105                 110         


Met Arg Ser Phe Pro Leu Val Asp Gly His Asn Asp Leu Pro Gln Val 
        115                 120                 125             


Leu Arg Gln Arg Tyr Lys Asn Val Leu Gln Asp Val Asn Leu Arg Asn 
    130                 135                 140                 


Phe Ser His Gly Gln Thr Ser Leu Asp Arg Leu Arg Asp Gly Leu Val 
145                 150                 155                 160 


Gly Ala Gln Phe Trp Ser Ala Ser Val Ser Cys Gln Ser Gln Asp Gln 
                165                 170                 175     


Thr Ala Val Arg Leu Ala Leu Glu Gln Ile Asp Leu Ile His Arg Met 
            180                 185                 190         


Cys Ala Ser Tyr Ser Glu Leu Glu Leu Val Thr Ser Ala Glu Gly Leu 
        195                 200                 205             


Asn Ser Ser Gln Lys Leu Ala Cys Leu Ile Gly Val Glu Gly Gly His 
    210                 215                 220                 


Ser Leu Asp Ser Ser Leu Ser Val Leu Arg Ser Phe Tyr Val Leu Gly 
225                 230                 235                 240 


Val Arg Tyr Leu Thr Leu Thr Phe Thr Cys Ser Thr Pro Trp Ala Glu 
                245                 250                 255     


Ser Ser Thr Lys Phe Arg His His Met Tyr Thr Asn Val Ser Gly Leu 
            260                 265                 270         


Thr Ser Phe Gly Glu Lys Val Val Glu Glu Leu Asn Arg Leu Gly Met 
        275                 280                 285             


Met Ile Asp Leu Ser Tyr Ala Ser Asp Thr Leu Ile Arg Arg Val Leu 
    290                 295                 300                 


Glu Val Ser Gln Ala Pro Val Ile Phe Ser His Ser Ala Ala Arg Ala 
305                 310                 315                 320 


Val Cys Asp Asn Leu Leu Asn Val Pro Asp Asp Ile Leu Gln Leu Leu 
                325                 330                 335     


Lys Lys Asn Gly Gly Ile Val Met Val Thr Leu Ser Met Gly Val Leu 
            340                 345                 350         


Gln Cys Asn Leu Leu Ala Asn Val Ser Thr Val Ala Asp His Phe Asp 
        355                 360                 365             


His Ile Arg Ala Val Ile Gly Ser Glu Phe Ile Gly Ile Gly Gly Asn 
    370                 375                 380                 


Tyr Asp Gly Thr Gly Arg Phe Pro Gln Gly Leu Glu Asp Val Ser Thr 
385                 390                 395                 400 


Tyr Pro Val Leu Ile Glu Glu Leu Leu Ser Arg Ser Trp Ser Glu Glu 
                405                 410                 415     


Glu Leu Gln Gly Val Leu Arg Gly Asn Leu Leu Arg Val Phe Arg Gln 
            420                 425                 430         


Val Glu Lys Val Arg Glu Glu Ser Arg Ala Gln Ser Pro Val Glu Ala 
        435                 440                 445             


Glu Phe Pro Tyr Gly Gln Leu Ser Thr Ser Cys His Ser His Leu Val 
    450                 455                 460                 


Pro Gln Asn Gly His Gln Ala Thr His Leu Glu Val Thr Lys Gln Pro 
465                 470                 475                 480 


Thr Asn Arg Val Pro Trp Arg Ser Ser Asn Ala Ser Pro Tyr Leu Val 
                485                 490                 495     


Pro Gly Leu Val Ala Ala Ala Thr Ile Pro Thr Phe Thr Gln Trp Leu 
            500                 505                 510         


Cys 
    


<210>  4417
<211>  357
<212>  PRT
<213>  Homo Sapiens

<400>  4417

Met Ala Thr Val Ile His Asn Pro Leu Lys Ala Leu Gly Asp Gln Phe 
1               5                   10                  15      


Tyr Lys Glu Ala Ile Glu His Cys Arg Ser Tyr Asn Ser Arg Leu Cys 
            20                  25                  30          


Ala Glu Arg Ser Val Arg Leu Pro Phe Leu Asp Ser Gln Thr Gly Val 
        35                  40                  45              


Ala Gln Asn Asn Cys Tyr Ile Trp Met Glu Lys Arg His Arg Gly Pro 
    50                  55                  60                  


Gly Leu Ala Pro Gly Gln Leu Tyr Thr Tyr Pro Ala Arg Cys Trp Arg 
65                  70                  75                  80  


Lys Lys Arg Arg Leu His Pro Pro Glu Asp Pro Lys Leu Arg Leu Leu 
                85                  90                  95      


Glu Ile Lys Pro Glu Val Glu Leu Pro Leu Lys Lys Asp Gly Phe Thr 
            100                 105                 110         


Ser Glu Ser Thr Thr Leu Glu Ala Leu Leu Arg Gly Glu Gly Val Glu 
        115                 120                 125             


Lys Lys Val Asp Ala Arg Glu Glu Glu Ser Ile Gln Glu Ile Gln Arg 
    130                 135                 140                 


Val Leu Glu Asn Asp Glu Asn Val Glu Glu Gly Asn Glu Glu Glu Asp 
145                 150                 155                 160 


Leu Glu Glu Asp Ile Pro Lys Arg Lys Asn Arg Thr Arg Gly Arg Ala 
                165                 170                 175     


Arg Gly Ser Ala Gly Gly Arg Arg Arg His Asp Ala Ala Ser Gln Glu 
            180                 185                 190         


Asp His Asp Lys Pro Tyr Val Cys Asp Ile Cys Gly Lys Arg Tyr Lys 
        195                 200                 205             


Asn Arg Pro Gly Leu Ser Tyr His Tyr Ala His Thr His Leu Ala Ser 
    210                 215                 220                 


Glu Glu Gly Asp Glu Ala Gln Asp Gln Glu Thr Arg Ser Pro Pro Asn 
225                 230                 235                 240 


His Arg Asn Glu Asn His Arg Pro Gln Lys Gly Pro Asp Gly Thr Val 
                245                 250                 255     


Ile Pro Asn Asn Tyr Cys Asp Phe Cys Leu Gly Gly Ser Asn Met Asn 
            260                 265                 270         


Lys Lys Ser Gly Arg Pro Glu Glu Leu Val Ser Cys Ala Asp Cys Gly 
        275                 280                 285             


Arg Ser Ala His Leu Gly Gly Glu Gly Arg Lys Glu Lys Glu Ala Ala 
    290                 295                 300                 


Ala Ala Ala Arg Thr Thr Glu Asp Leu Phe Gly Ser Thr Ser Glu Ser 
305                 310                 315                 320 


Asp Thr Ser Thr Phe His Gly Phe Asp Glu Asp Asp Leu Glu Glu Pro 
                325                 330                 335     


Arg Ser Cys Arg Gly Arg Arg Ser Gly Arg Gly Ser Pro Thr Ala Asp 
            340                 345                 350         


Lys Lys Gly Ser Cys 
        355         


<210>  4418
<211>  357
<212>  PRT
<213>  Homo Sapiens

<400>  4418

Met Ala Thr Val Ile His Asn Pro Leu Lys Ala Leu Gly Asp Gln Phe 
1               5                   10                  15      


Tyr Lys Glu Ala Ile Glu His Cys Arg Ser Tyr Asn Ser Arg Leu Cys 
            20                  25                  30          


Ala Glu Arg Ser Val Arg Leu Pro Phe Leu Asp Ser Gln Thr Gly Val 
        35                  40                  45              


Ala Gln Asn Asn Cys Tyr Ile Trp Met Glu Lys Arg His Arg Gly Pro 
    50                  55                  60                  


Gly Leu Ala Pro Gly Gln Leu Tyr Thr Tyr Pro Ala Arg Cys Trp Arg 
65                  70                  75                  80  


Lys Lys Arg Arg Leu His Pro Pro Glu Asp Pro Lys Leu Arg Leu Leu 
                85                  90                  95      


Glu Ile Lys Pro Glu Val Glu Leu Pro Leu Lys Lys Asp Gly Phe Thr 
            100                 105                 110         


Ser Glu Ser Thr Thr Leu Glu Ala Leu Leu Arg Gly Glu Gly Val Glu 
        115                 120                 125             


Lys Lys Val Asp Ala Arg Glu Glu Glu Ser Ile Gln Glu Ile Gln Arg 
    130                 135                 140                 


Val Leu Glu Asn Asp Glu Asn Val Glu Glu Gly Asn Glu Glu Glu Asp 
145                 150                 155                 160 


Leu Glu Glu Asp Ile Pro Lys Arg Lys Asn Arg Thr Arg Gly Arg Ala 
                165                 170                 175     


Arg Gly Ser Ala Gly Gly Arg Arg Arg His Asp Ala Ala Ser Gln Glu 
            180                 185                 190         


Asp His Asp Lys Pro Tyr Val Cys Asp Ile Cys Gly Lys Arg Tyr Lys 
        195                 200                 205             


Asn Arg Pro Gly Leu Ser Tyr His Tyr Ala His Thr His Leu Ala Ser 
    210                 215                 220                 


Glu Glu Gly Asp Glu Ala Gln Asp Gln Glu Thr Arg Ser Pro Pro Asn 
225                 230                 235                 240 


His Arg Asn Glu Asn His Arg Pro Gln Lys Gly Pro Asp Gly Thr Val 
                245                 250                 255     


Ile Pro Asn Asn Tyr Cys Asp Phe Cys Leu Gly Gly Ser Asn Met Asn 
            260                 265                 270         


Lys Lys Ser Gly Arg Pro Glu Glu Leu Val Ser Cys Ala Asp Cys Gly 
        275                 280                 285             


Arg Ser Ala His Leu Gly Gly Glu Gly Arg Lys Glu Lys Glu Ala Ala 
    290                 295                 300                 


Ala Ala Ala Arg Thr Thr Glu Asp Leu Phe Gly Ser Thr Ser Glu Ser 
305                 310                 315                 320 


Asp Thr Ser Thr Phe His Gly Phe Asp Glu Asp Asp Leu Glu Glu Pro 
                325                 330                 335     


Arg Ser Cys Arg Gly Arg Arg Ser Gly Arg Gly Ser Pro Thr Ala Asp 
            340                 345                 350         


Lys Lys Gly Ser Cys 
        355         


<210>  4419
<211>  378
<212>  PRT
<213>  Homo Sapiens

<400>  4419

Met Ala Thr Val Ile His Asn Pro Leu Lys Ala Leu Gly Asp Gln Phe 
1               5                   10                  15      


Tyr Lys Glu Ala Ile Glu His Cys Arg Ser Tyr Asn Ser Arg Leu Cys 
            20                  25                  30          


Ala Glu Arg Ser Val Arg Leu Pro Phe Leu Asp Ser Gln Thr Gly Val 
        35                  40                  45              


Ala Gln Asn Asn Cys Tyr Ile Trp Met Glu Lys Arg His Arg Gly Pro 
    50                  55                  60                  


Gly Leu Ala Pro Gly Gln Leu Tyr Thr Tyr Pro Ala Arg Cys Trp Arg 
65                  70                  75                  80  


Lys Lys Arg Arg Leu His Pro Pro Glu Asp Pro Lys Leu Arg Leu Leu 
                85                  90                  95      


Glu Ile Lys Pro Glu Val Glu Leu Pro Leu Lys Lys Asp Gly Phe Thr 
            100                 105                 110         


Ser Glu Ser Thr Thr Leu Glu Ala Leu Leu Arg Gly Glu Gly Val Glu 
        115                 120                 125             


Lys Lys Val Asp Ala Arg Glu Glu Glu Ser Ile Gln Glu Ile Gln Arg 
    130                 135                 140                 


Val Leu Glu Asn Asp Glu Asn Val Glu Glu Gly Asn Glu Glu Glu Asp 
145                 150                 155                 160 


Leu Glu Glu Asp Ile Pro Lys Arg Lys Asn Arg Thr Arg Gly Arg Ala 
                165                 170                 175     


Arg Gly Ser Ala Gly Gly Arg Arg Arg His Asp Ala Ala Ser Gln Glu 
            180                 185                 190         


Asp His Asp Lys Pro Tyr Val Cys Asp Ile Cys Gly Lys Arg Tyr Lys 
        195                 200                 205             


Asn Arg Pro Gly Leu Ser Tyr His Tyr Ala His Thr His Leu Ala Ser 
    210                 215                 220                 


Glu Glu Gly Asp Glu Ala Gln Asp Gln Glu Thr Arg Ser Pro Pro Asn 
225                 230                 235                 240 


His Arg Asn Glu Asn His Arg Pro Gln Lys Gly Pro Asp Gly Thr Val 
                245                 250                 255     


Ile Pro Asn Asn Tyr Cys Asp Phe Cys Leu Gly Gly Ser Asn Met Asn 
            260                 265                 270         


Lys Lys Ser Gly Arg Pro Glu Glu Leu Val Ser Cys Ala Asp Cys Gly 
        275                 280                 285             


Arg Ser Gly His Pro Thr Cys Leu Gln Phe Thr Leu Asn Met Thr Glu 
    290                 295                 300                 


Ala Val Lys Thr Tyr Lys Trp Gln Cys Ile Glu Cys Lys Ser Cys Ile 
305                 310                 315                 320 


Leu Cys Gly Thr Ser Glu Asn Asp Asp Gln Leu Leu Phe Cys Asp Asp 
                325                 330                 335     


Cys Asp Arg Gly Tyr His Met Tyr Cys Leu Asn Pro Pro Val Ala Glu 
            340                 345                 350         


Pro Pro Glu Gly Ser Trp Ser Cys His Leu Cys Trp Glu Leu Leu Lys 
        355                 360                 365             


Glu Lys Ala Ser Ala Phe Gly Cys Gln Ala 
    370                 375             


<210>  4420
<211>  412
<212>  PRT
<213>  Homo Sapiens

<400>  4420

Met Phe Tyr Gly Arg Ile Asn Gly Arg Asn Phe Ala Ala Ser Ser Leu 
1               5                   10                  15      


Pro Val Ala Phe Ala Ala Thr Pro Leu Met Leu Phe Leu Pro Asn Pro 
            20                  25                  30          


Gln Leu Ile Phe Ser Phe Pro Ile Ser Ser Arg Asn His Ile Thr Gly 
        35                  40                  45              


Leu Met Pro Pro Gly Lys Leu Lys Leu Glu Asn Leu Phe His Met Cys 
    50                  55                  60                  


Thr Arg Leu Gly Asp Gln Phe Tyr Lys Glu Ala Ile Glu His Cys Arg 
65                  70                  75                  80  


Ser Tyr Asn Ser Arg Leu Cys Ala Glu Arg Ser Val Arg Leu Pro Phe 
                85                  90                  95      


Leu Asp Ser Gln Thr Gly Val Ala Gln Asn Asn Cys Tyr Ile Trp Met 
            100                 105                 110         


Glu Lys Arg His Arg Gly Pro Gly Leu Ala Pro Gly Gln Leu Tyr Thr 
        115                 120                 125             


Tyr Pro Ala Arg Cys Trp Arg Lys Lys Arg Arg Leu His Pro Pro Glu 
    130                 135                 140                 


Asp Pro Lys Leu Arg Leu Leu Glu Ile Lys Pro Glu Val Glu Leu Pro 
145                 150                 155                 160 


Leu Lys Lys Asp Gly Phe Thr Ser Glu Ser Thr Thr Leu Glu Ala Leu 
                165                 170                 175     


Leu Arg Gly Glu Gly Val Glu Lys Lys Val Asp Ala Arg Glu Glu Glu 
            180                 185                 190         


Ser Ile Gln Glu Ile Gln Arg Val Leu Glu Asn Asp Glu Asn Val Glu 
        195                 200                 205             


Glu Gly Asn Glu Glu Glu Asp Leu Glu Glu Asp Ile Pro Lys Arg Lys 
    210                 215                 220                 


Asn Arg Thr Arg Gly Arg Ala Arg Gly Ser Ala Gly Gly Arg Arg Arg 
225                 230                 235                 240 


His Asp Ala Ala Ser Gln Glu Asp His Asp Lys Pro Tyr Val Cys Asp 
                245                 250                 255     


Ile Cys Gly Lys Arg Tyr Lys Asn Arg Pro Gly Leu Ser Tyr His Tyr 
            260                 265                 270         


Ala His Thr His Leu Ala Ser Glu Glu Gly Asp Glu Ala Gln Asp Gln 
        275                 280                 285             


Glu Thr Arg Ser Pro Pro Asn His Arg Asn Glu Asn His Arg Pro Gln 
    290                 295                 300                 


Lys Gly Pro Asp Gly Thr Val Ile Pro Asn Asn Tyr Cys Asp Phe Cys 
305                 310                 315                 320 


Leu Gly Gly Ser Asn Met Asn Lys Lys Ser Gly Arg Pro Glu Glu Leu 
                325                 330                 335     


Val Ser Cys Ala Asp Cys Gly Arg Ser Ala His Leu Gly Gly Glu Gly 
            340                 345                 350         


Arg Lys Glu Lys Glu Ala Ala Ala Ala Ala Arg Thr Thr Glu Asp Leu 
        355                 360                 365             


Phe Gly Ser Thr Ser Glu Ser Asp Thr Ser Thr Phe His Gly Phe Asp 
    370                 375                 380                 


Glu Asp Asp Leu Glu Glu Pro Arg Ser Cys Arg Gly Arg Arg Ser Gly 
385                 390                 395                 400 


Arg Gly Ser Pro Thr Ala Asp Lys Lys Gly Ser Cys 
                405                 410         


<210>  4421
<211>  412
<212>  PRT
<213>  Homo Sapiens

<400>  4421

Met Phe Tyr Gly Arg Ile Asn Gly Arg Asn Phe Ala Ala Ser Ser Leu 
1               5                   10                  15      


Pro Val Ala Phe Ala Ala Thr Pro Leu Met Leu Phe Leu Pro Asn Pro 
            20                  25                  30          


Gln Leu Ile Phe Ser Phe Pro Ile Ser Ser Arg Asn His Ile Thr Gly 
        35                  40                  45              


Leu Met Pro Pro Gly Lys Leu Lys Leu Glu Asn Leu Phe His Met Cys 
    50                  55                  60                  


Thr Arg Leu Gly Asp Gln Phe Tyr Lys Glu Ala Ile Glu His Cys Arg 
65                  70                  75                  80  


Ser Tyr Asn Ser Arg Leu Cys Ala Glu Arg Ser Val Arg Leu Pro Phe 
                85                  90                  95      


Leu Asp Ser Gln Thr Gly Val Ala Gln Asn Asn Cys Tyr Ile Trp Met 
            100                 105                 110         


Glu Lys Arg His Arg Gly Pro Gly Leu Ala Pro Gly Gln Leu Tyr Thr 
        115                 120                 125             


Tyr Pro Ala Arg Cys Trp Arg Lys Lys Arg Arg Leu His Pro Pro Glu 
    130                 135                 140                 


Asp Pro Lys Leu Arg Leu Leu Glu Ile Lys Pro Glu Val Glu Leu Pro 
145                 150                 155                 160 


Leu Lys Lys Asp Gly Phe Thr Ser Glu Ser Thr Thr Leu Glu Ala Leu 
                165                 170                 175     


Leu Arg Gly Glu Gly Val Glu Lys Lys Val Asp Ala Arg Glu Glu Glu 
            180                 185                 190         


Ser Ile Gln Glu Ile Gln Arg Val Leu Glu Asn Asp Glu Asn Val Glu 
        195                 200                 205             


Glu Gly Asn Glu Glu Glu Asp Leu Glu Glu Asp Ile Pro Lys Arg Lys 
    210                 215                 220                 


Asn Arg Thr Arg Gly Arg Ala Arg Gly Ser Ala Gly Gly Arg Arg Arg 
225                 230                 235                 240 


His Asp Ala Ala Ser Gln Glu Asp His Asp Lys Pro Tyr Val Cys Asp 
                245                 250                 255     


Ile Cys Gly Lys Arg Tyr Lys Asn Arg Pro Gly Leu Ser Tyr His Tyr 
            260                 265                 270         


Ala His Thr His Leu Ala Ser Glu Glu Gly Asp Glu Ala Gln Asp Gln 
        275                 280                 285             


Glu Thr Arg Ser Pro Pro Asn His Arg Asn Glu Asn His Arg Pro Gln 
    290                 295                 300                 


Lys Gly Pro Asp Gly Thr Val Ile Pro Asn Asn Tyr Cys Asp Phe Cys 
305                 310                 315                 320 


Leu Gly Gly Ser Asn Met Asn Lys Lys Ser Gly Arg Pro Glu Glu Leu 
                325                 330                 335     


Val Ser Cys Ala Asp Cys Gly Arg Ser Ala His Leu Gly Gly Glu Gly 
            340                 345                 350         


Arg Lys Glu Lys Glu Ala Ala Ala Ala Ala Arg Thr Thr Glu Asp Leu 
        355                 360                 365             


Phe Gly Ser Thr Ser Glu Ser Asp Thr Ser Thr Phe His Gly Phe Asp 
    370                 375                 380                 


Glu Asp Asp Leu Glu Glu Pro Arg Ser Cys Arg Gly Arg Arg Ser Gly 
385                 390                 395                 400 


Arg Gly Ser Pro Thr Ala Asp Lys Lys Gly Ser Cys 
                405                 410         


<210>  4422
<211>  367
<212>  PRT
<213>  Homo Sapiens

<400>  4422

Met Gly Phe Thr Asp Leu Glu Glu Pro Ile Ser Gly Cys Pro Gly Gly 
1               5                   10                  15      


Pro Trp Ala Leu Gly Leu Gly Asp Gln Phe Tyr Lys Glu Ala Ile Glu 
            20                  25                  30          


His Cys Arg Ser Tyr Asn Ser Arg Leu Cys Ala Glu Arg Ser Val Arg 
        35                  40                  45              


Leu Pro Phe Leu Asp Ser Gln Thr Gly Val Ala Gln Asn Asn Cys Tyr 
    50                  55                  60                  


Ile Trp Met Glu Lys Arg His Arg Gly Pro Gly Leu Ala Pro Gly Gln 
65                  70                  75                  80  


Leu Tyr Thr Tyr Pro Ala Arg Cys Trp Arg Lys Lys Arg Arg Leu His 
                85                  90                  95      


Pro Pro Glu Asp Pro Lys Leu Arg Leu Leu Glu Ile Lys Pro Glu Val 
            100                 105                 110         


Glu Leu Pro Leu Lys Lys Asp Gly Phe Thr Ser Glu Ser Thr Thr Leu 
        115                 120                 125             


Glu Ala Leu Leu Arg Gly Glu Gly Val Glu Lys Lys Val Asp Ala Arg 
    130                 135                 140                 


Glu Glu Glu Ser Ile Gln Glu Ile Gln Arg Val Leu Glu Asn Asp Glu 
145                 150                 155                 160 


Asn Val Glu Glu Gly Asn Glu Glu Glu Asp Leu Glu Glu Asp Ile Pro 
                165                 170                 175     


Lys Arg Lys Asn Arg Thr Arg Gly Arg Ala Arg Gly Ser Ala Gly Gly 
            180                 185                 190         


Arg Arg Arg His Asp Ala Ala Ser Gln Glu Asp His Asp Lys Pro Tyr 
        195                 200                 205             


Val Cys Asp Ile Cys Gly Lys Arg Tyr Lys Asn Arg Pro Gly Leu Ser 
    210                 215                 220                 


Tyr His Tyr Ala His Thr His Leu Ala Ser Glu Glu Gly Asp Glu Ala 
225                 230                 235                 240 


Gln Asp Gln Glu Thr Arg Ser Pro Pro Asn His Arg Asn Glu Asn His 
                245                 250                 255     


Arg Pro Gln Lys Gly Pro Asp Gly Thr Val Ile Pro Asn Asn Tyr Cys 
            260                 265                 270         


Asp Phe Cys Leu Gly Gly Ser Asn Met Asn Lys Lys Ser Gly Arg Pro 
        275                 280                 285             


Glu Glu Leu Val Ser Cys Ala Asp Cys Gly Arg Ser Ala His Leu Gly 
    290                 295                 300                 


Gly Glu Gly Arg Lys Glu Lys Glu Ala Ala Ala Ala Ala Arg Thr Thr 
305                 310                 315                 320 


Glu Asp Leu Phe Gly Ser Thr Ser Glu Ser Asp Thr Ser Thr Phe His 
                325                 330                 335     


Gly Phe Asp Glu Asp Asp Leu Glu Glu Pro Arg Ser Cys Arg Gly Arg 
            340                 345                 350         


Arg Ser Gly Arg Gly Ser Pro Thr Ala Asp Lys Lys Gly Ser Cys 
        355                 360                 365         


<210>  4423
<211>  367
<212>  PRT
<213>  Homo Sapiens

<400>  4423

Met Gly Phe Thr Asp Leu Glu Glu Pro Ile Ser Gly Cys Pro Gly Gly 
1               5                   10                  15      


Pro Trp Ala Leu Gly Leu Gly Asp Gln Phe Tyr Lys Glu Ala Ile Glu 
            20                  25                  30          


His Cys Arg Ser Tyr Asn Ser Arg Leu Cys Ala Glu Arg Ser Val Arg 
        35                  40                  45              


Leu Pro Phe Leu Asp Ser Gln Thr Gly Val Ala Gln Asn Asn Cys Tyr 
    50                  55                  60                  


Ile Trp Met Glu Lys Arg His Arg Gly Pro Gly Leu Ala Pro Gly Gln 
65                  70                  75                  80  


Leu Tyr Thr Tyr Pro Ala Arg Cys Trp Arg Lys Lys Arg Arg Leu His 
                85                  90                  95      


Pro Pro Glu Asp Pro Lys Leu Arg Leu Leu Glu Ile Lys Pro Glu Val 
            100                 105                 110         


Glu Leu Pro Leu Lys Lys Asp Gly Phe Thr Ser Glu Ser Thr Thr Leu 
        115                 120                 125             


Glu Ala Leu Leu Arg Gly Glu Gly Val Glu Lys Lys Val Asp Ala Arg 
    130                 135                 140                 


Glu Glu Glu Ser Ile Gln Glu Ile Gln Arg Val Leu Glu Asn Asp Glu 
145                 150                 155                 160 


Asn Val Glu Glu Gly Asn Glu Glu Glu Asp Leu Glu Glu Asp Ile Pro 
                165                 170                 175     


Lys Arg Lys Asn Arg Thr Arg Gly Arg Ala Arg Gly Ser Ala Gly Gly 
            180                 185                 190         


Arg Arg Arg His Asp Ala Ala Ser Gln Glu Asp His Asp Lys Pro Tyr 
        195                 200                 205             


Val Cys Asp Ile Cys Gly Lys Arg Tyr Lys Asn Arg Pro Gly Leu Ser 
    210                 215                 220                 


Tyr His Tyr Ala His Thr His Leu Ala Ser Glu Glu Gly Asp Glu Ala 
225                 230                 235                 240 


Gln Asp Gln Glu Thr Arg Ser Pro Pro Asn His Arg Asn Glu Asn His 
                245                 250                 255     


Arg Pro Gln Lys Gly Pro Asp Gly Thr Val Ile Pro Asn Asn Tyr Cys 
            260                 265                 270         


Asp Phe Cys Leu Gly Gly Ser Asn Met Asn Lys Lys Ser Gly Arg Pro 
        275                 280                 285             


Glu Glu Leu Val Ser Cys Ala Asp Cys Gly Arg Ser Ala His Leu Gly 
    290                 295                 300                 


Gly Glu Gly Arg Lys Glu Lys Glu Ala Ala Ala Ala Ala Arg Thr Thr 
305                 310                 315                 320 


Glu Asp Leu Phe Gly Ser Thr Ser Glu Ser Asp Thr Ser Thr Phe His 
                325                 330                 335     


Gly Phe Asp Glu Asp Asp Leu Glu Glu Pro Arg Ser Cys Arg Gly Arg 
            340                 345                 350         


Arg Ser Gly Arg Gly Ser Pro Thr Ala Asp Lys Lys Gly Ser Cys 
        355                 360                 365         


<210>  4424
<211>  170
<212>  PRT
<213>  Homo Sapiens

<400>  4424

Met Lys Thr Pro Trp Lys Val Leu Leu Gly Leu Leu Gly Ala Ala Ala 
1               5                   10                  15      


Leu Val Thr Ile Ile Thr Val Pro Val Val Leu Leu Asn Lys Gly Asn 
            20                  25                  30          


Asp Ala Thr Ala Asp Ser Arg Lys Thr Tyr Thr Leu Thr Asp Tyr Leu 
        35                  40                  45              


Lys Asn Thr Tyr Arg Leu Lys Leu Tyr Ser Leu Arg Trp Ile Ser Asp 
    50                  55                  60                  


His Glu Tyr Leu Tyr Lys Gln Glu Asn Asn Ile Leu Val Phe Asn Ala 
65                  70                  75                  80  


Glu Tyr Gly Asn Ser Ser Val Phe Leu Glu Asn Ser Thr Phe Asp Glu 
                85                  90                  95      


Phe Gly His Ser Ile Asn Asp Tyr Ser Ile Ser Pro Asp Gly Gln Phe 
            100                 105                 110         


Ile Leu Leu Glu Tyr Asn Tyr Val Lys Gln Trp Arg His Ser Tyr Thr 
        115                 120                 125             


Ala Ser Tyr Asp Ile Tyr Asp Leu Asn Lys Arg Gln Leu Ile Thr Glu 
    130                 135                 140                 


Glu Arg Ile Pro Asn Asn Thr Gln Trp Val Thr Trp Ser Pro Val Gly 
145                 150                 155                 160 


His Lys Leu Val Ser Ile Cys Leu Glu Gln 
                165                 170 


<210>  4425
<211>  766
<212>  PRT
<213>  Homo Sapiens

<400>  4425

Met Lys Thr Pro Trp Lys Val Leu Leu Gly Leu Leu Gly Ala Ala Ala 
1               5                   10                  15      


Leu Val Thr Ile Ile Thr Val Pro Val Val Leu Leu Asn Lys Gly Thr 
            20                  25                  30          


Asp Asp Ala Thr Ala Asp Ser Arg Lys Thr Tyr Thr Leu Thr Asp Tyr 
        35                  40                  45              


Leu Lys Asn Thr Tyr Arg Leu Lys Leu Tyr Ser Leu Arg Trp Ile Ser 
    50                  55                  60                  


Asp His Glu Tyr Leu Tyr Lys Gln Glu Asn Asn Ile Leu Val Phe Asn 
65                  70                  75                  80  


Ala Glu Tyr Gly Asn Ser Ser Val Phe Leu Glu Asn Ser Thr Phe Asp 
                85                  90                  95      


Glu Phe Gly His Ser Ile Asn Asp Tyr Ser Ile Ser Pro Asp Gly Gln 
            100                 105                 110         


Phe Ile Leu Leu Glu Tyr Asn Tyr Val Lys Gln Trp Arg His Ser Tyr 
        115                 120                 125             


Thr Ala Ser Tyr Asp Ile Tyr Asp Leu Asn Lys Arg Gln Leu Ile Thr 
    130                 135                 140                 


Glu Glu Arg Ile Pro Asn Asn Thr Gln Trp Val Thr Trp Ser Pro Val 
145                 150                 155                 160 


Gly His Lys Leu Ala Tyr Val Trp Asn Asn Asp Ile Tyr Val Lys Ile 
                165                 170                 175     


Glu Pro Asn Leu Pro Ser Tyr Arg Ile Thr Trp Thr Gly Lys Glu Asp 
            180                 185                 190         


Ile Ile Tyr Asn Gly Ile Thr Asp Trp Val Tyr Glu Glu Glu Val Phe 
        195                 200                 205             


Ser Ala Tyr Ser Ala Leu Trp Trp Ser Pro Asn Gly Thr Phe Leu Ala 
    210                 215                 220                 


Tyr Ala Gln Phe Asn Asp Thr Glu Val Pro Leu Ile Glu Tyr Ser Phe 
225                 230                 235                 240 


Tyr Ser Asp Glu Ser Leu Gln Tyr Pro Lys Thr Val Arg Val Pro Tyr 
                245                 250                 255     


Pro Lys Ala Gly Ala Val Asn Pro Thr Val Lys Phe Phe Val Val Asn 
            260                 265                 270         


Thr Asp Ser Leu Ser Ser Val Thr Asn Ala Thr Ser Ile Gln Ile Thr 
        275                 280                 285             


Ala Pro Ala Ser Met Leu Ile Gly Asp His Tyr Leu Cys Asp Val Thr 
    290                 295                 300                 


Trp Ala Thr Gln Glu Arg Ile Ser Leu Gln Trp Leu Arg Arg Ile Gln 
305                 310                 315                 320 


Asn Tyr Ser Val Met Asp Ile Cys Asp Tyr Asp Glu Ser Ser Gly Arg 
                325                 330                 335     


Trp Asn Cys Leu Val Ala Arg Gln His Ile Glu Met Ser Thr Thr Gly 
            340                 345                 350         


Trp Val Gly Arg Phe Arg Pro Ser Glu Pro His Phe Thr Leu Asp Gly 
        355                 360                 365             


Asn Ser Phe Tyr Lys Ile Ile Ser Asn Glu Glu Gly Tyr Arg His Ile 
    370                 375                 380                 


Cys Tyr Phe Gln Ile Asp Lys Lys Asp Cys Thr Phe Ile Thr Lys Gly 
385                 390                 395                 400 


Thr Trp Glu Val Ile Gly Ile Glu Ala Leu Thr Ser Asp Tyr Leu Tyr 
                405                 410                 415     


Tyr Ile Ser Asn Glu Tyr Lys Gly Met Pro Gly Gly Arg Asn Leu Tyr 
            420                 425                 430         


Lys Ile Gln Leu Ser Asp Tyr Thr Lys Val Thr Cys Leu Ser Cys Glu 
        435                 440                 445             


Leu Asn Pro Glu Arg Cys Gln Tyr Tyr Ser Val Ser Phe Ser Lys Glu 
    450                 455                 460                 


Ala Lys Tyr Tyr Gln Leu Arg Cys Ser Gly Pro Gly Leu Pro Leu Tyr 
465                 470                 475                 480 


Thr Leu His Ser Ser Val Asn Asp Lys Gly Leu Arg Val Leu Glu Asp 
                485                 490                 495     


Asn Ser Ala Leu Asp Lys Met Leu Gln Asn Val Gln Met Pro Ser Lys 
            500                 505                 510         


Lys Leu Asp Phe Ile Ile Leu Asn Glu Thr Lys Phe Trp Tyr Gln Met 
        515                 520                 525             


Ile Leu Pro Pro His Phe Asp Lys Ser Lys Lys Tyr Pro Leu Leu Leu 
    530                 535                 540                 


Asp Val Tyr Ala Gly Pro Cys Ser Gln Lys Ala Asp Thr Val Phe Arg 
545                 550                 555                 560 


Leu Asn Trp Ala Thr Tyr Leu Ala Ser Thr Glu Asn Ile Ile Val Ala 
                565                 570                 575     


Ser Phe Asp Gly Arg Gly Ser Gly Tyr Gln Gly Asp Lys Ile Met His 
            580                 585                 590         


Ala Ile Asn Arg Arg Leu Gly Thr Phe Glu Val Glu Asp Gln Ile Glu 
        595                 600                 605             


Ala Ala Arg Gln Phe Ser Lys Met Gly Phe Val Asp Asn Lys Arg Ile 
    610                 615                 620                 


Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Thr Ser Met Val Leu 
625                 630                 635                 640 


Gly Ser Gly Ser Gly Val Phe Lys Cys Gly Ile Ala Val Ala Pro Val 
                645                 650                 655     


Ser Arg Trp Glu Tyr Tyr Asp Ser Val Tyr Thr Glu Arg Tyr Met Gly 
            660                 665                 670         


Leu Pro Thr Pro Glu Asp Asn Leu Asp His Tyr Arg Asn Ser Thr Val 
        675                 680                 685             


Met Ser Arg Ala Glu Asn Phe Lys Gln Val Glu Tyr Leu Leu Ile His 
    690                 695                 700                 


Gly Thr Ala Asp Asp Asn Val His Phe Gln Gln Ser Ala Gln Ile Ser 
705                 710                 715                 720 


Lys Ala Leu Val Asp Val Gly Val Asp Phe Gln Ala Met Trp Tyr Thr 
                725                 730                 735     


Asp Glu Asp His Gly Ile Ala Ser Ser Thr Ala His Gln His Ile Tyr 
            740                 745                 750         


Thr His Met Ser His Phe Ile Lys Gln Cys Phe Ser Leu Pro 
        755                 760                 765     


<210>  4426
<211>  118
<212>  PRT
<213>  Homo Sapiens

<400>  4426

Met Lys Thr Pro Trp Lys Val Leu Leu Gly Leu Leu Gly Ala Ala Ala 
1               5                   10                  15      


Leu Val Thr Ile Ile Thr Val Pro Val Val Leu Leu Asn Lys Gly Thr 
            20                  25                  30          


Asp Asp Ala Thr Ala Asp Ser Arg Lys Thr Tyr Thr Leu Thr Asp Tyr 
        35                  40                  45              


Leu Lys Asn Thr Tyr Arg Leu Lys Leu Tyr Ser Leu Arg Trp Ile Ser 
    50                  55                  60                  


Asp His Glu Tyr Leu Tyr Lys Gln Glu Asn Asn Ile Leu Val Phe Asn 
65                  70                  75                  80  


Ala Glu Tyr Gly Asn Ser Ser Val Phe Leu Glu Asn Ser Thr Phe His 
                85                  90                  95      


Met Ala Lys Trp Ile Phe Leu Ser Phe Leu Lys Cys Ser Leu Pro Trp 
            100                 105                 110         


Leu Leu Phe Ser Leu Leu 
        115             


<210>  4427
<211>  118
<212>  PRT
<213>  Homo Sapiens

<400>  4427

Met Lys Thr Pro Trp Lys Val Leu Leu Gly Leu Leu Gly Ala Ala Ala 
1               5                   10                  15      


Leu Val Thr Ile Ile Thr Val Pro Val Val Leu Leu Asn Lys Gly Thr 
            20                  25                  30          


Asp Asp Ala Thr Ala Asp Ser Arg Lys Thr Tyr Thr Leu Thr Asp Tyr 
        35                  40                  45              


Leu Lys Asn Thr Tyr Arg Leu Lys Leu Tyr Ser Leu Arg Trp Ile Ser 
    50                  55                  60                  


Asp His Glu Tyr Leu Tyr Lys Gln Glu Asn Asn Ile Leu Val Phe Asn 
65                  70                  75                  80  


Ala Glu Tyr Gly Asn Ser Ser Val Phe Leu Glu Asn Ser Thr Phe His 
                85                  90                  95      


Met Ala Lys Trp Ile Phe Leu Ser Phe Leu Lys Cys Ser Leu Pro Trp 
            100                 105                 110         


Leu Leu Phe Ser Leu Leu 
        115             


<210>  4428
<211>  86
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4428

Xaa Asp Ala Thr Ala Asp Ser Arg Lys Thr Tyr Thr Leu Thr Asp Tyr 
1               5                   10                  15      


Leu Lys Asn Thr Tyr Arg Leu Lys Leu Tyr Ser Leu Arg Trp Ile Ser 
            20                  25                  30          


Asp His Glu Tyr Leu Tyr Lys Gln Glu Asn Asn Ile Leu Val Phe Asn 
        35                  40                  45              


Ala Glu Tyr Gly Asn Ser Ser Val Phe Leu Glu Asn Ser Thr Phe His 
    50                  55                  60                  


Met Ala Lys Trp Ile Phe Leu Ser Phe Leu Lys Cys Ser Leu Pro Trp 
65                  70                  75                  80  


Leu Leu Phe Ser Leu Leu 
                85      


<210>  4429
<211>  272
<212>  PRT
<213>  Homo Sapiens

<400>  4429

Ala Pro Trp Ala Pro Val Leu Leu Leu Ala Leu Gly Leu Arg Gly Leu 
1               5                   10                  15      


Gln Ala Gly Ala Arg Arg Ala Pro Asp Pro Gly Phe Gln Glu Arg Phe 
            20                  25                  30          


Phe Gln Gln Arg Leu Asp His Phe Asn Phe Glu Arg Phe Gly Asn Lys 
        35                  40                  45              


Thr Phe Pro Gln Arg Phe Leu Val Ser Asp Arg Phe Trp Val Arg Gly 
    50                  55                  60                  


Glu Gly Pro Ile Phe Phe Tyr Thr Gly Asn Glu Gly Asp Val Trp Ala 
65                  70                  75                  80  


Phe Ala Asn Asn Ser Ala Phe Val Ala Glu Leu Ala Ala Glu Arg Gly 
                85                  90                  95      


Ala Leu Leu Val Phe Ala Glu His Arg Tyr Tyr Gly Lys Ser Leu Pro 
            100                 105                 110         


Phe Gly Ala Gln Ser Thr Gln Arg Gly His Thr Glu Leu Leu Thr Val 
        115                 120                 125             


Glu Gln Ala Leu Ala Asp Phe Ala Glu Leu Leu Arg Ala Leu Arg Arg 
    130                 135                 140                 


Asp Leu Gly Ala Gln Asp Ala Pro Ala Ile Ala Phe Gly Gly Arg Lys 
145                 150                 155                 160 


Pro Ser His Leu Ser Ser Gln Pro Pro Ala Gln Leu Gly Cys Ala Ala 
                165                 170                 175     


Thr Leu Ala Ala Phe Pro Ser Glu Ser Cys Thr Arg Thr Trp Pro Arg 
            180                 185                 190         


Val Gly Ile Cys Gly Ser Gln Lys Cys Arg Pro Pro Cys Gly Thr Cys 
        195                 200                 205             


Gly Pro Leu Arg Arg Lys Arg Gly Asn Gly Val Leu Gly Ala Ala Ala 
    210                 215                 220                 


Leu Thr Leu Cys Pro Ser Pro Ser Tyr Gly Gly Met Leu Ser Ala Tyr 
225                 230                 235                 240 


Leu Arg Met Lys Tyr Pro His Leu Val Ala Gly Ala Leu Ala Ala Ser 
                245                 250                 255     


Ala Pro Val Leu Ala Val Ala Gly Leu Gly Asp Ser Asn Gln Phe Phe 
            260                 265                 270         


<210>  4430
<211>  492
<212>  PRT
<213>  Homo Sapiens

<400>  4430

Met Gly Ser Ala Pro Trp Ala Pro Val Leu Leu Leu Ala Leu Gly Leu 
1               5                   10                  15      


Arg Gly Leu Gln Ala Gly Ala Arg Arg Ala Pro Asp Pro Gly Phe Gln 
            20                  25                  30          


Glu Arg Phe Phe Gln Gln Arg Leu Asp His Phe Asn Phe Glu Arg Phe 
        35                  40                  45              


Gly Asn Lys Thr Phe Pro Gln Arg Phe Leu Val Ser Asp Arg Phe Trp 
    50                  55                  60                  


Val Arg Gly Glu Gly Pro Ile Phe Phe Tyr Thr Gly Asn Glu Gly Asp 
65                  70                  75                  80  


Val Trp Ala Phe Ala Asn Asn Ser Ala Phe Val Ala Glu Leu Ala Ala 
                85                  90                  95      


Glu Arg Gly Ala Leu Leu Val Phe Ala Glu His Arg Tyr Tyr Gly Lys 
            100                 105                 110         


Ser Leu Pro Phe Gly Ala Gln Ser Thr Gln Arg Gly His Thr Glu Leu 
        115                 120                 125             


Leu Thr Val Glu Gln Ala Leu Ala Asp Phe Ala Glu Leu Leu Arg Ala 
    130                 135                 140                 


Leu Arg Arg Asp Leu Gly Ala Gln Asp Ala Pro Ala Ile Ala Phe Gly 
145                 150                 155                 160 


Gly Ser Tyr Gly Gly Met Leu Ser Ala Tyr Leu Arg Met Lys Tyr Pro 
                165                 170                 175     


His Leu Val Ala Gly Ala Leu Ala Ala Ser Ala Pro Val Leu Ala Val 
            180                 185                 190         


Ala Gly Leu Gly Asp Ser Asn Gln Phe Phe Arg Asp Val Thr Ala Asp 
        195                 200                 205             


Phe Glu Gly Gln Ser Pro Lys Cys Thr Gln Gly Val Arg Glu Ala Phe 
    210                 215                 220                 


Arg Gln Ile Lys Asp Leu Phe Leu Gln Gly Ala Tyr Asp Thr Val Arg 
225                 230                 235                 240 


Trp Glu Phe Gly Thr Cys Gln Pro Leu Ser Asp Glu Lys Asp Leu Thr 
                245                 250                 255     


Gln Leu Phe Met Phe Ala Arg Asn Ala Phe Thr Val Leu Ala Met Met 
            260                 265                 270         


Asp Tyr Pro Tyr Pro Thr Asp Phe Leu Gly Pro Leu Pro Ala Asn Pro 
        275                 280                 285             


Val Lys Val Gly Cys Asp Arg Leu Leu Ser Glu Ala Gln Arg Ile Thr 
    290                 295                 300                 


Gly Leu Arg Ala Leu Ala Gly Leu Val Tyr Asn Ala Ser Gly Ser Glu 
305                 310                 315                 320 


His Cys Tyr Asp Ile Tyr Arg Leu Tyr His Ser Cys Ala Asp Pro Thr 
                325                 330                 335     


Gly Cys Gly Thr Gly Pro Asp Ala Arg Ala Trp Asp Tyr Gln Ala Cys 
            340                 345                 350         


Thr Glu Ile Asn Leu Thr Phe Ala Ser Asn Asn Val Thr Asp Met Phe 
        355                 360                 365             


Pro Asp Leu Pro Phe Thr Asp Glu Leu Arg Gln Arg Tyr Cys Leu Asp 
    370                 375                 380                 


Thr Trp Gly Val Trp Pro Arg Pro Asp Trp Leu Leu Thr Ser Phe Trp 
385                 390                 395                 400 


Gly Gly Asp Leu Arg Ala Ala Ser Asn Ile Ile Phe Ser Asn Gly Asn 
                405                 410                 415     


Leu Asp Pro Trp Ala Gly Gly Gly Ile Arg Arg Asn Leu Ser Ala Ser 
            420                 425                 430         


Val Ile Ala Val Thr Ile Gln Gly Gly Ala His His Leu Asp Leu Arg 
        435                 440                 445             


Ala Ser His Pro Glu Asp Pro Ala Ser Val Val Glu Ala Arg Lys Leu 
    450                 455                 460                 


Glu Ala Thr Ile Ile Gly Glu Trp Val Lys Ala Ala Arg Arg Glu Gln 
465                 470                 475                 480 


Gln Pro Ala Leu Arg Gly Gly Pro Arg Leu Ser Leu 
                485                 490         


<210>  4431
<211>  61
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4431

Xaa Ser Gly Ser Glu His Cys Tyr Asp Ile Tyr Arg Leu Tyr His Ser 
1               5                   10                  15      


Cys Ala Asp Pro Thr Gly Cys Gly Thr Gly Pro Asp Ala Arg Ala Trp 
            20                  25                  30          


Asp Tyr Gln Ile Ser Glu Pro Pro Ala Thr Ser Ser Ser Pro Thr Gly 
        35                  40                  45              


Thr Trp Thr Pro Gly Gln Gly Ala Gly Phe Gly Gly Thr 
    50                  55                  60      


<210>  4432
<211>  155
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4432

Xaa Thr Phe Pro Gln Arg Phe Leu Val Ser Asp Arg Phe Trp Val Arg 
1               5                   10                  15      


Gly Glu Gly Pro Ile Phe Phe Tyr Thr Gly Asn Glu Gly Asp Val Trp 
            20                  25                  30          


Ala Phe Ala Asn Asn Ser Ala Phe Val Ala Glu Leu Ala Ala Glu Arg 
        35                  40                  45              


Gly Ala Leu Leu Val Phe Ala Glu His Arg Tyr Tyr Gly Lys Ser Leu 
    50                  55                  60                  


Pro Phe Gly Ala Gln Ser Thr Gln Arg Gly His Thr Glu Leu Leu Thr 
65                  70                  75                  80  


Val Glu Gln Ala Leu Ala Asp Phe Ala Glu Leu Leu Arg Ala Leu Arg 
                85                  90                  95      


Arg Asp Leu Gly Ala Gln Asp Ala Pro Ala Ile Ala Phe Gly Gly Ser 
            100                 105                 110         


Leu Arg His Gly Pro Leu Gly Val Arg His Leu Pro Ala Ala Val Arg 
        115                 120                 125             


Arg Glu Gly Pro Asp Pro Ala Leu His Val Arg Pro Glu Cys Leu His 
    130                 135                 140                 


Arg Ala Gly His Asp Gly Leu Pro Leu Pro His 
145                 150                 155 


<210>  4433
<211>  244
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4433

Xaa Thr Val Arg Trp Glu Phe Gly Thr Cys Gln Pro Leu Ser Asp Glu 
1               5                   10                  15      


Lys Asp Leu Thr Gln Leu Phe Met Phe Ala Arg Asn Ala Phe Thr Val 
            20                  25                  30          


Leu Ala Met Met Asp Tyr Pro Tyr Pro Thr Asp Phe Leu Gly Pro Leu 
        35                  40                  45              


Pro Ala Asn Pro Val Lys Val Gly Cys Asp Arg Leu Leu Ser Glu Ala 
    50                  55                  60                  


Gln Arg Ile Thr Gly Leu Arg Ala Leu Ala Gly Ala Leu Pro Pro Ala 
65                  70                  75                  80  


Pro Asp Gly Cys Ala Asp Pro Thr Gly Cys Gly Thr Gly Pro Asp Ala 
                85                  90                  95      


Arg Ala Trp Asp Tyr Gln Ala Cys Thr Glu Ile Asn Leu Thr Phe Ala 
            100                 105                 110         


Ser Asn Asn Val Thr Asp Met Phe Pro Asp Leu Pro Phe Thr Asp Glu 
        115                 120                 125             


Leu Arg Gln Arg Tyr Cys Leu Asp Thr Trp Gly Val Trp Pro Arg Pro 
    130                 135                 140                 


Asp Trp Leu Leu Thr Ser Phe Trp Gly Gly Asp Leu Arg Ala Ala Ser 
145                 150                 155                 160 


Asn Ile Ile Phe Ser Asn Gly Asn Leu Asp Pro Trp Ala Gly Gly Gly 
                165                 170                 175     


Ile Arg Arg Asn Leu Ser Ala Ser Val Ile Ala Val Thr Ile Gln Gly 
            180                 185                 190         


Gly Ala His His Leu Asp Leu Arg Ala Ser His Pro Glu Asp Pro Ala 
        195                 200                 205             


Ser Val Val Glu Ala Arg Lys Leu Glu Ala Thr Ile Ile Gly Glu Trp 
    210                 215                 220                 


Val Lys Ala Ala Arg Arg Glu Gln Gln Pro Ala Leu Arg Gly Gly Pro 
225                 230                 235                 240 


Arg Leu Ser Leu 
                


<210>  4434
<211>  120
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4434

Xaa Val Leu Leu Leu Ala Leu Gly Leu Arg Gly Leu Gln Ala Gly Ala 
1               5                   10                  15      


Arg Arg Ala Pro Asp Pro Gly Phe Gln Glu Arg Phe Phe Gln Gln Arg 
            20                  25                  30          


Leu Asp His Phe Asn Phe Glu Arg Phe Gly Asn Lys Thr Phe Pro Gln 
        35                  40                  45              


Arg Phe Leu Val Ser Gly Ser Gly Ser Gly Ala Arg Gly Pro Ser Ser 
    50                  55                  60                  


Ser Thr Leu Gly Thr Arg Ala Thr Cys Gly Pro Ser Pro Thr Thr Arg 
65                  70                  75                  80  


Pro Ser Ser Arg Ser Trp Arg Pro Ser Gly Gly Leu Tyr Trp Ser Ser 
                85                  90                  95      


Arg Ser Thr Ala Thr Thr Gly Ser Arg Cys Arg Ser Val Arg Ser Pro 
            100                 105                 110         


Arg Ser Ala Gly Thr Arg Ser Cys 
        115                 120 


<210>  4435
<211>  201
<212>  PRT
<213>  Homo Sapiens

<400>  4435

Met Asp Leu Ser Leu Leu Trp Val Leu Leu Pro Leu Val Thr Met Ala 
1               5                   10                  15      


Trp Gly Gln Tyr Gly Asp Tyr Gly Tyr Pro Tyr Gln Gln Tyr His Asp 
            20                  25                  30          


Tyr Ser Asp Asp Gly Trp Val Asn Leu Asn Arg Gln Gly Phe Ser Tyr 
        35                  40                  45              


Gln Cys Pro Gln Gly Gln Val Ile Val Ala Val Arg Ser Ile Phe Ser 
    50                  55                  60                  


Lys Lys Glu Gly Ser Asp Arg Gln Trp Asn Tyr Ala Cys Met Pro Thr 
65                  70                  75                  80  


Pro Gln Ser Leu Gly Glu Pro Thr Glu Cys Trp Trp Glu Glu Ile Asn 
                85                  90                  95      


Arg Ala Gly Met Glu Trp Tyr Gln Thr Cys Ser Asn Asn Gly Leu Val 
            100                 105                 110         


Ala Gly Phe Gln Ser Arg Tyr Phe Glu Ser Val Leu Asp Arg Glu Trp 
        115                 120                 125             


Gln Phe Tyr Cys Cys Arg Tyr Ser Lys Arg Cys Pro Tyr Ser Cys Trp 
    130                 135                 140                 


Leu Thr Thr Glu Tyr Pro Gly His Tyr Gly Glu Glu Met Asp Met Ile 
145                 150                 155                 160 


Ser Tyr Asn Tyr Asp Tyr Tyr Ile Arg Gly Ala Thr Thr Thr Phe Ser 
                165                 170                 175     


Ala Val Glu Arg Asp Arg Gln Trp Lys Phe Ile Met Cys Arg Met Thr 
            180                 185                 190         


Glu Tyr Asp Cys Glu Phe Ala Asn Val 
        195                 200     


<210>  4436
<211>  349
<212>  PRT
<213>  Homo Sapiens

<400>  4436

Met Ala Gly Pro Ala Ile His Thr Ala Pro Met Leu Phe Leu Val Leu 
1               5                   10                  15      


Leu Leu Pro Leu Glu Leu Ser Leu Ala Gly Ala Leu Ala Pro Gly Thr 
            20                  25                  30          


Pro Ala Arg Asn Leu Pro Glu Asn His Ile Asp Leu Pro Gly Pro Ala 
        35                  40                  45              


Leu Trp Thr Pro Gln Ala Ser His His Arg Arg Arg Gly Pro Gly Lys 
    50                  55                  60                  


Lys Glu Trp Gly Pro Gly Leu Pro Ser Gln Ala Gln Asp Gly Ala Val 
65                  70                  75                  80  


Val Thr Ala Thr Arg Gln Ala Ser Arg Leu Pro Glu Ala Glu Gly Leu 
                85                  90                  95      


Leu Pro Glu Gln Ser Pro Ala Gly Leu Leu Gln Asp Lys Asp Leu Leu 
            100                 105                 110         


Leu Gly Leu Ala Leu Pro Tyr Pro Glu Lys Glu Asn Arg Pro Pro Gly 
        115                 120                 125             


Trp Glu Arg Thr Arg Lys Arg Ser Arg Glu His Lys Arg Arg Arg Asp 
    130                 135                 140                 


Arg Leu Arg Leu His Gln Gly Arg Ala Leu Val Arg Gly Pro Ser Ser 
145                 150                 155                 160 


Leu Met Lys Lys Ala Glu Leu Ser Glu Ala Gln Val Leu Asp Ala Ala 
                165                 170                 175     


Met Glu Glu Ser Ser Thr Ser Leu Ala Pro Thr Met Phe Phe Leu Thr 
            180                 185                 190         


Thr Phe Glu Ala Ala Pro Ala Thr Glu Glu Ser Leu Ile Leu Pro Val 
        195                 200                 205             


Thr Ser Leu Arg Pro Gln Gln Ala Gln Pro Arg Ser Asp Gly Glu Val 
    210                 215                 220                 


Met Pro Thr Leu Asp Met Ala Leu Phe Asp Trp Thr Asp Tyr Glu Asp 
225                 230                 235                 240 


Leu Lys Pro Asp Gly Trp Pro Ser Ala Lys Lys Lys Glu Lys His Arg 
                245                 250                 255     


Gly Lys Leu Ser Ser Asp Gly Asn Glu Thr Ser Pro Ala Glu Gly Glu 
            260                 265                 270         


Pro Cys Asp His His Gln Asp Cys Leu Pro Gly Thr Cys Cys Asp Leu 
        275                 280                 285             


Arg Glu His Leu Cys Thr Pro His Asn Arg Gly Leu Asn Asn Lys Cys 
    290                 295                 300                 


Phe Asp Asp Cys Met Cys Val Glu Gly Leu Arg Cys Tyr Ala Lys Phe 
305                 310                 315                 320 


His Arg Asn Arg Arg Val Thr Arg Arg Lys Gly Arg Cys Val Glu Pro 
                325                 330                 335     


Glu Thr Ala Asn Gly Asp Gln Gly Ser Phe Ile Asn Val 
            340                 345                 


<210>  4437
<211>  136
<212>  PRT
<213>  Homo Sapiens

<400>  4437

Met Arg Thr His Thr Arg Gly Ala Pro Ser Val Phe Phe Ile Tyr Leu 
1               5                   10                  15      


Leu Cys Phe Val Ser Ala Tyr Ile Thr Asp Glu Asn Pro Glu Val Met 
            20                  25                  30          


Ile Pro Phe Thr Asn Ala Asn Tyr Asp Ser His Pro Met Leu Tyr Phe 
        35                  40                  45              


Ser Arg Ala Glu Val Ala Glu Leu Gln Leu Arg Ala Ala Ser Ser His 
    50                  55                  60                  


Glu His Ile Ala Ala Arg Leu Thr Glu Ala Val His Thr Met Leu Ser 
65                  70                  75                  80  


Ser Pro Leu Glu Tyr Leu Pro Pro Trp Asp Pro Lys Asp Tyr Ser Ala 
                85                  90                  95      


Arg Trp Asn Glu Ile Phe Gly Asn Asn Leu Gly Ala Leu Ala Met Phe 
            100                 105                 110         


Cys Val Leu Tyr Pro Glu Asn Ile Glu Ala Arg Asp Met Ala Lys Asp 
        115                 120                 125             


Tyr Met Glu Arg Met Ala Ala Gln 
    130                 135     


<210>  4438
<211>  139
<212>  PRT
<213>  Homo Sapiens

<400>  4438

Met Arg Thr His Thr Arg Gly Ala Pro Ser Val Phe Phe Ile Tyr Leu 
1               5                   10                  15      


Leu Cys Phe Val Ser Ala Tyr Ile Thr Asp Glu Asn Pro Glu Val Met 
            20                  25                  30          


Ile Pro Phe Thr Asn Ala Asn Tyr Asp Ser His Pro Met Leu Tyr Phe 
        35                  40                  45              


Ser Arg Ala Glu Val Ala Glu Leu Gln Leu Arg Ala Ala Ser Ser His 
    50                  55                  60                  


Glu His Ile Ala Ala Arg Leu Thr Glu Ala Val His Thr Met Leu Ser 
65                  70                  75                  80  


Ser Pro Leu Glu Tyr Leu Pro Pro Trp Asp Pro Lys Asp Tyr Ser Ala 
                85                  90                  95      


Arg Trp Asn Glu Ile Phe Gly Asn Asn Leu Gly Ala Leu Ala Met Phe 
            100                 105                 110         


Cys Val Leu Tyr Pro Glu Asn Ile Glu Ala Arg Asp Met Ala Lys Asp 
        115                 120                 125             


Tyr Met Glu Arg Met Ala Ala Gln Pro Ser Trp 
    130                 135                 


<210>  4439
<211>  144
<212>  PRT
<213>  Homo Sapiens

<400>  4439

Met Arg Thr His Thr Arg Gly Ala Pro Ser Val Phe Phe Ile Tyr Leu 
1               5                   10                  15      


Leu Cys Phe Val Ser Ala Tyr Ile Thr Asp Glu Asn Pro Glu Val Met 
            20                  25                  30          


Ile Pro Phe Thr Asn Ala Asn Tyr Asp Ser His Pro Met Leu Tyr Phe 
        35                  40                  45              


Ser Arg Ala Glu Val Ala Glu Leu Gln Leu Arg Ala Ala Ser Ser His 
    50                  55                  60                  


Glu His Ile Ala Ala Arg Leu Thr Glu Ala Val His Thr Met Leu Ser 
65                  70                  75                  80  


Ser Pro Leu Glu Tyr Leu Pro Pro Trp Asp Pro Lys Asp Tyr Ser Ala 
                85                  90                  95      


Arg Trp Asn Glu Ile Phe Gly Asn Asn Leu Gly Ala Leu Ala Met Phe 
            100                 105                 110         


Cys Val Leu Tyr Pro Glu Asn Ile Glu Ala Arg Asp Met Ala Lys Asp 
        115                 120                 125             


Tyr Met Glu Arg Met Ala Ala Gln Pro Ser Trp Leu Val Lys Asp Ala 
    130                 135                 140                 


<210>  4440
<211>  228
<212>  PRT
<213>  Homo Sapiens

<400>  4440

Met Arg Thr His Thr Arg Gly Ala Pro Ser Val Phe Phe Ile Tyr Leu 
1               5                   10                  15      


Leu Cys Phe Val Ser Ala Tyr Ile Thr Asp Glu Asn Pro Glu Val Met 
            20                  25                  30          


Ile Pro Phe Thr Asn Ala Asn Tyr Asp Ser His Pro Met Leu Tyr Phe 
        35                  40                  45              


Ser Arg Ala Glu Val Ala Glu Leu Gln Leu Arg Ala Ala Ser Ser His 
    50                  55                  60                  


Glu His Ile Ala Ala Arg Leu Thr Glu Ala Val His Thr Met Leu Ser 
65                  70                  75                  80  


Ser Pro Leu Glu Tyr Leu Pro Pro Trp Asp Pro Lys Asp Tyr Ser Ala 
                85                  90                  95      


Arg Trp Asn Glu Ile Phe Gly Asn Asn Leu Gly Ala Leu Ala Met Phe 
            100                 105                 110         


Cys Val Leu Tyr Pro Glu Asn Ile Glu Ala Arg Asp Met Ala Lys Asp 
        115                 120                 125             


Tyr Met Glu Arg Met Ala Ala Gln Pro Ser Trp Leu Val Lys Asp Ala 
    130                 135                 140                 


Pro Trp Asp Glu Val Pro Leu Ala His Ser Leu Val Gly Phe Ala Thr 
145                 150                 155                 160 


Ala Tyr Asp Phe Leu Tyr Asn Tyr Leu Ser Lys Thr Gln Gln Glu Lys 
                165                 170                 175     


Phe Leu Glu Val Ile Ala Asn Ala Ser Gly Tyr Met Tyr Glu Thr Ser 
            180                 185                 190         


Tyr Arg Arg Gly Trp Gly Phe Gln Tyr Leu His Asn His Gln Pro Thr 
        195                 200                 205             


Asn Cys Met Ala Leu Leu Thr Gly Ser Leu Val Leu Met Asn Gln Gly 
    210                 215                 220                 


Met Met Ala Ala 
225             


<210>  4441
<211>  228
<212>  PRT
<213>  Homo Sapiens

<400>  4441

Met Arg Thr His Thr Arg Gly Ala Pro Ser Val Phe Phe Ile Tyr Leu 
1               5                   10                  15      


Leu Cys Phe Val Ser Ala Tyr Ile Thr Asp Glu Asn Pro Glu Val Met 
            20                  25                  30          


Ile Pro Phe Thr Asn Ala Asn Tyr Asp Ser His Pro Met Leu Tyr Phe 
        35                  40                  45              


Ser Arg Ala Glu Val Ala Glu Leu Gln Leu Arg Ala Ala Ser Ser His 
    50                  55                  60                  


Glu His Ile Ala Ala Arg Leu Thr Glu Ala Val His Thr Met Leu Ser 
65                  70                  75                  80  


Ser Pro Leu Glu Tyr Leu Pro Pro Trp Asp Pro Lys Asp Tyr Ser Ala 
                85                  90                  95      


Arg Trp Asn Glu Ile Phe Gly Asn Asn Leu Gly Ala Leu Ala Met Phe 
            100                 105                 110         


Cys Val Leu Tyr Pro Glu Asn Ile Glu Ala Arg Asp Met Ala Lys Asp 
        115                 120                 125             


Tyr Met Glu Arg Met Ala Ala Gln Pro Ser Trp Leu Val Lys Asp Ala 
    130                 135                 140                 


Pro Trp Asp Glu Val Pro Leu Ala His Ser Leu Val Gly Phe Ala Thr 
145                 150                 155                 160 


Ala Tyr Asp Phe Leu Tyr Asn Tyr Leu Ser Lys Thr Gln Gln Glu Lys 
                165                 170                 175     


Phe Leu Glu Val Ile Ala Asn Ala Ser Gly Tyr Met Tyr Glu Thr Ser 
            180                 185                 190         


Tyr Arg Arg Gly Trp Gly Phe Gln Tyr Leu His Asn His Gln Pro Thr 
        195                 200                 205             


Asn Cys Met Ala Leu Leu Thr Gly Ser Leu Val Leu Met Asn Gln Gly 
    210                 215                 220                 


Met Met Ala Ala 
225             


<210>  4442
<211>  958
<212>  PRT
<213>  Homo Sapiens

<400>  4442

Met Arg Thr His Thr Arg Gly Ala Pro Ser Val Phe Phe Ile Tyr Leu 
1               5                   10                  15      


Leu Cys Phe Val Ser Ala Tyr Ile Thr Asp Glu Asn Pro Glu Val Met 
            20                  25                  30          


Ile Pro Phe Thr Asn Ala Asn Tyr Asp Ser His Pro Met Leu Tyr Phe 
        35                  40                  45              


Ser Arg Ala Glu Val Ala Glu Leu Gln Leu Arg Ala Ala Ser Ser His 
    50                  55                  60                  


Glu His Ile Ala Ala Arg Leu Thr Glu Ala Val His Thr Met Leu Ser 
65                  70                  75                  80  


Ser Pro Leu Glu Tyr Leu Pro Pro Trp Asp Pro Lys Asp Tyr Ser Ala 
                85                  90                  95      


Arg Trp Asn Glu Ile Phe Gly Asn Asn Leu Gly Ala Leu Ala Met Phe 
            100                 105                 110         


Cys Val Leu Tyr Pro Glu Asn Ile Glu Ala Arg Asp Met Ala Lys Asp 
        115                 120                 125             


Tyr Met Glu Arg Met Ala Ala Gln Pro Ser Trp Leu Val Lys Asp Ala 
    130                 135                 140                 


Pro Trp Asp Glu Val Pro Leu Ala His Ser Leu Val Gly Phe Ala Thr 
145                 150                 155                 160 


Ala Tyr Asp Phe Leu Tyr Asn Tyr Leu Ser Lys Thr Gln Gln Glu Lys 
                165                 170                 175     


Phe Leu Glu Val Ile Ala Asn Ala Ser Gly Tyr Met Tyr Glu Thr Ser 
            180                 185                 190         


Tyr Arg Arg Gly Trp Gly Phe Gln Tyr Leu His Asn His Gln Pro Thr 
        195                 200                 205             


Asn Cys Met Ala Leu Leu Thr Gly Ser Leu Val Leu Met Asn Gln Gly 
    210                 215                 220                 


Tyr Leu Gln Glu Ala Tyr Leu Trp Thr Lys Gln Val Leu Thr Ile Met 
225                 230                 235                 240 


Glu Lys Ser Leu Val Leu Leu Arg Glu Val Thr Asp Gly Ser Leu Tyr 
                245                 250                 255     


Glu Gly Val Ala Tyr Gly Ser Tyr Thr Thr Arg Ser Leu Phe Gln Tyr 
            260                 265                 270         


Met Phe Leu Val Gln Arg His Phe Asn Ile Asn His Phe Gly His Pro 
        275                 280                 285             


Trp Leu Lys Gln His Phe Ala Phe Met Tyr Arg Thr Ile Leu Pro Gly 
    290                 295                 300                 


Phe Gln Arg Thr Val Ala Ile Ala Asp Ser Asn Tyr Asn Trp Phe Tyr 
305                 310                 315                 320 


Gly Pro Glu Ser Gln Leu Val Phe Leu Asp Lys Phe Val Met Arg Asn 
                325                 330                 335     


Gly Ser Gly Asn Trp Leu Ala Asp Gln Ile Arg Arg Asn Arg Val Val 
            340                 345                 350         


Glu Gly Pro Gly Thr Pro Ser Lys Gly Gln Arg Trp Cys Thr Leu His 
        355                 360                 365             


Thr Glu Phe Leu Trp Tyr Asp Gly Ser Leu Lys Ser Val Pro Pro Pro 
    370                 375                 380                 


Asp Phe Gly Thr Pro Thr Leu His Tyr Phe Glu Asp Trp Gly Val Val 
385                 390                 395                 400 


Thr Tyr Gly Ser Ala Leu Pro Ala Glu Ile Asn Arg Ser Phe Leu Ser 
                405                 410                 415     


Phe Lys Ser Gly Lys Leu Gly Gly Arg Ala Ile Tyr Asp Ile Val His 
            420                 425                 430         


Arg Asn Lys Tyr Lys Asp Trp Ile Lys Gly Trp Arg Asn Phe Asn Ala 
        435                 440                 445             


Gly His Glu His Pro Asp Gln Asn Ser Phe Thr Phe Ala Pro Asn Gly 
    450                 455                 460                 


Val Pro Phe Ile Thr Glu Ala Leu Tyr Gly Pro Lys Tyr Thr Phe Phe 
465                 470                 475                 480 


Asn Asn Val Leu Met Phe Ser Pro Ala Val Ser Lys Ser Cys Phe Ser 
                485                 490                 495     


Pro Trp Val Gly Gln Val Thr Glu Asp Cys Ser Ser Lys Trp Ser Lys 
            500                 505                 510         


Tyr Lys His Asp Leu Ala Ala Ser Cys Gln Gly Arg Val Val Ala Ala 
        515                 520                 525             


Glu Glu Lys Asn Gly Val Val Phe Ile Arg Gly Glu Gly Val Gly Ala 
    530                 535                 540                 


Tyr Asn Pro Gln Leu Asn Leu Lys Asn Val Gln Arg Asn Leu Ile Leu 
545                 550                 555                 560 


Leu His Pro Gln Leu Leu Leu Leu Val Asp Gln Ile His Leu Gly Glu 
                565                 570                 575     


Glu Ser Pro Leu Glu Thr Ala Ala Ser Phe Phe His Asn Val Asp Val 
            580                 585                 590         


Pro Phe Glu Glu Thr Val Val Asp Gly Val His Gly Ala Phe Ile Arg 
        595                 600                 605             


Gln Arg Asp Gly Leu Tyr Lys Met Tyr Trp Met Asp Asp Thr Gly Tyr 
    610                 615                 620                 


Ser Glu Lys Ala Thr Phe Ala Ser Val Thr Tyr Pro Arg Gly Tyr Pro 
625                 630                 635                 640 


Tyr Asn Gly Thr Asn Tyr Val Asn Val Thr Met His Leu Arg Ser Pro 
                645                 650                 655     


Ile Thr Arg Ala Ala Tyr Leu Phe Ile Gly Pro Ser Ile Asp Val Gln 
            660                 665                 670         


Ser Phe Thr Val His Gly Asp Ser Gln Gln Leu Asp Val Phe Ile Ala 
        675                 680                 685             


Thr Ser Lys His Ala Tyr Ala Thr Tyr Leu Trp Thr Gly Glu Ala Thr 
    690                 695                 700                 


Gly Gln Ser Ala Phe Ala Gln Val Ile Ala Asp Arg His Lys Ile Leu 
705                 710                 715                 720 


Phe Asp Arg Asn Ser Ala Ile Lys Ser Ser Ile Val Pro Glu Val Lys 
                725                 730                 735     


Asp Tyr Ala Ala Ile Val Glu Gln Asn Leu Gln His Phe Lys Pro Val 
            740                 745                 750         


Phe Gln Leu Leu Glu Lys Gln Ile Leu Ser Arg Val Arg Asn Thr Ala 
        755                 760                 765             


Ser Phe Arg Lys Thr Ala Glu Arg Leu Leu Arg Phe Ser Asp Lys Arg 
    770                 775                 780                 


Gln Thr Glu Glu Ala Ile Asp Arg Ile Phe Ala Ile Ser Gln Gln Gln 
785                 790                 795                 800 


Gln Gln Gln Ser Lys Ser Lys Lys Asn Arg Arg Ala Gly Lys Arg Tyr 
                805                 810                 815     


Lys Phe Val Asp Ala Val Pro Asp Ile Phe Ala Gln Ile Glu Val Asn 
            820                 825                 830         


Glu Lys Lys Ile Arg Gln Lys Ala Gln Ile Leu Ala Gln Lys Glu Leu 
        835                 840                 845             


Pro Ile Asp Glu Asp Glu Glu Met Lys Asp Leu Leu Asp Phe Ala Asp 
    850                 855                 860                 


Val Thr Tyr Glu Lys His Lys Asn Gly Gly Leu Ile Lys Gly Arg Phe 
865                 870                 875                 880 


Gly Gln Ala Arg Met Val Thr Thr Thr His Ser Arg Ala Pro Ser Leu 
                885                 890                 895     


Ser Ala Ser Tyr Thr Arg Leu Phe Leu Ile Leu Asn Ile Ala Ile Phe 
            900                 905                 910         


Phe Val Met Leu Ala Met Gln Leu Thr Tyr Phe Gln Arg Ala Gln Ser 
        915                 920                 925             


Leu His Gly Gln Arg Cys Leu Tyr Ala Val Leu Leu Ile Asp Ser Cys 
    930                 935                 940                 


Ile Leu Leu Trp Leu Tyr Ser Ser Cys Ser Gln Ser Gln Cys 
945                 950                 955             


<210>  4443
<211>  308
<212>  PRT
<213>  Homo Sapiens

<400>  4443

Met Arg Thr His Thr Arg Gly Ala Pro Ser Val Phe Phe Ile Tyr Leu 
1               5                   10                  15      


Leu Cys Phe Val Ser Ala Tyr Ile Thr Asp Glu Asn Pro Glu Val Met 
            20                  25                  30          


Ile Pro Phe Thr Asn Ala Asn Tyr Asp Ser His Pro Met Leu Tyr Phe 
        35                  40                  45              


Ser Arg Ala Glu Val Ala Glu Leu Gln Leu Arg Ala Ala Ser Ser His 
    50                  55                  60                  


Glu His Ile Ala Ala Arg Leu Thr Glu Ala Val His Thr Met Leu Ser 
65                  70                  75                  80  


Ser Pro Leu Glu Tyr Leu Pro Pro Trp Asp Pro Lys Asp Tyr Ser Ala 
                85                  90                  95      


Arg Trp Asn Glu Ile Phe Gly Asn Asn Leu Gly Ala Leu Ala Met Phe 
            100                 105                 110         


Cys Val Leu Tyr Pro Glu Asn Ile Glu Ala Arg Asp Met Ala Lys Asp 
        115                 120                 125             


Tyr Met Glu Arg Met Ala Ala Gln Pro Ser Trp Leu Val Lys Asp Ala 
    130                 135                 140                 


Pro Trp Asp Glu Val Pro Leu Ala His Ser Leu Val Gly Phe Ala Thr 
145                 150                 155                 160 


Ala Tyr Asp Phe Leu Tyr Asn Tyr Leu Ser Lys Thr Gln Gln Glu Lys 
                165                 170                 175     


Phe Leu Glu Val Ile Ala Asn Ala Ser Gly Tyr Met Tyr Glu Thr Ser 
            180                 185                 190         


Tyr Arg Arg Gly Trp Gly Phe Gln Tyr Leu His Asn His Gln Pro Thr 
        195                 200                 205             


Asn Cys Met Ala Leu Leu Thr Gly Ser Leu Val Leu Met Asn Gln Gly 
    210                 215                 220                 


Tyr Leu Gln Glu Ala Tyr Leu Trp Thr Lys Gln Val Leu Thr Ile Met 
225                 230                 235                 240 


Glu Lys Ser Leu Val Leu Leu Arg Glu Val Thr Asp Gly Ser Leu Tyr 
                245                 250                 255     


Glu Gly Val Ala Tyr Gly Ser Tyr Thr Thr Arg Ser Leu Phe Gln Tyr 
            260                 265                 270         


Met Phe Leu Val Gln Arg His Phe Asn Ile Asn His Phe Gly His Pro 
        275                 280                 285             


Trp Leu Lys Gln His Phe Ala Phe Met Tyr Arg Thr Ile Leu Pro Gly 
    290                 295                 300                 


Met Met Ala Ala 
305             


<210>  4444
<211>  958
<212>  PRT
<213>  Homo Sapiens

<400>  4444

Met Arg Thr His Thr Arg Gly Ala Pro Ser Val Phe Phe Ile Tyr Leu 
1               5                   10                  15      


Leu Cys Phe Val Ser Ala Tyr Ile Thr Asp Glu Asn Pro Glu Val Met 
            20                  25                  30          


Ile Pro Phe Thr Asn Ala Asn Tyr Asp Ser His Pro Met Leu Tyr Phe 
        35                  40                  45              


Ser Arg Ala Glu Val Ala Glu Leu Gln Leu Arg Ala Ala Ser Ser His 
    50                  55                  60                  


Glu His Ile Ala Ala Arg Leu Thr Glu Ala Val His Thr Met Leu Ser 
65                  70                  75                  80  


Ser Pro Leu Glu Tyr Leu Pro Pro Trp Asp Pro Lys Asp Tyr Ser Ala 
                85                  90                  95      


Arg Trp Asn Glu Ile Phe Gly Asn Asn Leu Gly Ala Leu Ala Met Phe 
            100                 105                 110         


Cys Val Leu Tyr Pro Glu Asn Ile Glu Ala Arg Asp Met Ala Lys Asp 
        115                 120                 125             


Tyr Met Glu Arg Met Ala Ala Gln Pro Ser Trp Leu Val Lys Asp Ala 
    130                 135                 140                 


Pro Trp Asp Glu Val Pro Leu Ala His Ser Leu Val Gly Phe Ala Thr 
145                 150                 155                 160 


Ala Tyr Asp Phe Leu Tyr Asn Tyr Leu Ser Lys Thr Gln Gln Glu Lys 
                165                 170                 175     


Phe Leu Glu Val Ile Ala Asn Ala Ser Gly Tyr Met Tyr Glu Thr Ser 
            180                 185                 190         


Tyr Arg Arg Gly Trp Gly Phe Gln Tyr Leu His Asn His Gln Pro Thr 
        195                 200                 205             


Asn Cys Met Ala Leu Leu Thr Gly Ser Leu Val Leu Met Asn Gln Gly 
    210                 215                 220                 


Tyr Leu Gln Glu Ala Tyr Leu Trp Thr Lys Gln Val Leu Thr Ile Met 
225                 230                 235                 240 


Glu Lys Ser Leu Val Leu Leu Arg Glu Val Thr Asp Gly Ser Leu Tyr 
                245                 250                 255     


Glu Gly Val Ala Tyr Gly Ser Tyr Thr Thr Arg Ser Leu Phe Gln Tyr 
            260                 265                 270         


Met Phe Leu Val Gln Arg His Phe Asn Ile Asn His Phe Gly His Pro 
        275                 280                 285             


Trp Leu Lys Gln His Phe Ala Phe Met Tyr Arg Thr Ile Leu Pro Gly 
    290                 295                 300                 


Phe Gln Arg Thr Val Ala Ile Ala Asp Ser Asn Tyr Asn Trp Phe Tyr 
305                 310                 315                 320 


Gly Pro Glu Ser Gln Leu Val Phe Leu Asp Lys Phe Val Met Arg Asn 
                325                 330                 335     


Gly Ser Gly Asn Trp Leu Ala Asp Gln Ile Arg Arg Asn Arg Val Val 
            340                 345                 350         


Glu Gly Pro Gly Thr Pro Ser Lys Gly Gln Arg Trp Cys Thr Leu His 
        355                 360                 365             


Thr Glu Phe Leu Trp Tyr Asp Gly Ser Leu Lys Ser Val Pro Pro Pro 
    370                 375                 380                 


Asp Phe Gly Thr Pro Thr Leu His Tyr Phe Glu Asp Trp Gly Val Val 
385                 390                 395                 400 


Thr Tyr Gly Ser Ala Leu Pro Ala Glu Ile Asn Arg Ser Phe Leu Ser 
                405                 410                 415     


Phe Lys Ser Gly Lys Leu Gly Gly Arg Ala Ile Tyr Asp Ile Val His 
            420                 425                 430         


Arg Asn Lys Tyr Lys Asp Trp Ile Lys Gly Trp Arg Asn Phe Asn Ala 
        435                 440                 445             


Gly His Glu His Pro Asp Gln Asn Ser Phe Thr Phe Ala Pro Asn Gly 
    450                 455                 460                 


Val Pro Phe Ile Thr Glu Ala Leu Tyr Gly Pro Lys Tyr Thr Phe Phe 
465                 470                 475                 480 


Asn Asn Val Leu Met Phe Ser Pro Ala Val Ser Lys Ser Cys Phe Ser 
                485                 490                 495     


Pro Trp Val Gly Gln Val Thr Glu Asp Cys Ser Ser Lys Trp Ser Lys 
            500                 505                 510         


Tyr Lys His Asp Leu Ala Ala Ser Cys Gln Gly Arg Val Val Ala Ala 
        515                 520                 525             


Glu Glu Lys Asn Gly Val Val Phe Ile Arg Gly Glu Gly Val Gly Ala 
    530                 535                 540                 


Tyr Asn Pro Gln Leu Asn Leu Lys Asn Val Gln Arg Asn Leu Ile Leu 
545                 550                 555                 560 


Leu His Pro Gln Leu Leu Leu Leu Val Asp Gln Ile His Leu Gly Glu 
                565                 570                 575     


Glu Ser Pro Leu Glu Thr Ala Ala Ser Phe Phe His Asn Val Asp Val 
            580                 585                 590         


Pro Phe Glu Glu Thr Val Val Asp Gly Val His Gly Ala Phe Ile Arg 
        595                 600                 605             


Gln Arg Asp Gly Leu Tyr Lys Met Tyr Trp Met Asp Asp Thr Gly Tyr 
    610                 615                 620                 


Ser Glu Lys Ala Thr Phe Ala Ser Val Thr Tyr Pro Arg Gly Tyr Pro 
625                 630                 635                 640 


Tyr Asn Gly Thr Asn Tyr Val Asn Val Thr Met His Leu Arg Ser Pro 
                645                 650                 655     


Ile Thr Arg Ala Ala Tyr Leu Phe Ile Gly Pro Ser Ile Asp Val Gln 
            660                 665                 670         


Ser Phe Thr Val His Gly Asp Ser Gln Gln Leu Asp Val Phe Ile Ala 
        675                 680                 685             


Thr Ser Lys His Ala Tyr Ala Thr Tyr Leu Trp Thr Gly Glu Ala Thr 
    690                 695                 700                 


Gly Gln Ser Ala Phe Ala Gln Val Ile Ala Asp Arg His Lys Ile Leu 
705                 710                 715                 720 


Phe Asp Arg Asn Ser Ala Ile Lys Ser Ser Ile Val Pro Glu Val Lys 
                725                 730                 735     


Asp Tyr Ala Ala Ile Val Glu Gln Asn Leu Gln His Phe Lys Pro Val 
            740                 745                 750         


Phe Gln Leu Leu Glu Lys Gln Ile Leu Ser Arg Val Arg Asn Thr Ala 
        755                 760                 765             


Ser Phe Arg Lys Thr Ala Glu Arg Leu Leu Arg Phe Ser Asp Lys Arg 
    770                 775                 780                 


Gln Thr Glu Glu Ala Ile Asp Arg Ile Phe Ala Ile Ser Gln Gln Gln 
785                 790                 795                 800 


Gln Gln Gln Ser Lys Ser Lys Lys Asn Arg Arg Ala Gly Lys Arg Tyr 
                805                 810                 815     


Lys Phe Val Asp Ala Val Pro Asp Ile Phe Ala Gln Ile Glu Val Asn 
            820                 825                 830         


Glu Lys Lys Ile Arg Gln Lys Ala Gln Ile Leu Ala Gln Lys Glu Leu 
        835                 840                 845             


Pro Ile Asp Glu Asp Glu Glu Met Lys Asp Leu Leu Asp Phe Ala Asp 
    850                 855                 860                 


Val Thr Tyr Glu Lys His Lys Asn Gly Gly Leu Ile Lys Gly Arg Phe 
865                 870                 875                 880 


Gly Gln Ala Arg Met Val Thr Thr Thr His Ser Arg Ala Pro Ser Leu 
                885                 890                 895     


Ser Ala Ser Tyr Thr Arg Leu Phe Leu Ile Leu Asn Ile Ala Ile Phe 
            900                 905                 910         


Phe Val Met Leu Ala Met Gln Leu Thr Tyr Phe Gln Arg Ala Gln Ser 
        915                 920                 925             


Leu His Gly Gln Arg Cys Leu Tyr Ala Val Leu Leu Ile Asp Ser Cys 
    930                 935                 940                 


Ile Leu Leu Trp Leu Tyr Ser Ser Cys Ser Gln Ser Gln Cys 
945                 950                 955             


<210>  4445
<211>  958
<212>  PRT
<213>  Homo Sapiens

<400>  4445

Met Arg Thr His Thr Arg Gly Ala Pro Ser Val Phe Phe Ile Tyr Leu 
1               5                   10                  15      


Leu Cys Phe Val Ser Ala Tyr Ile Thr Asp Glu Asn Pro Glu Val Met 
            20                  25                  30          


Ile Pro Phe Thr Asn Ala Asn Tyr Asp Ser His Pro Met Leu Tyr Phe 
        35                  40                  45              


Ser Arg Ala Glu Val Ala Glu Leu Gln Leu Arg Ala Ala Ser Ser His 
    50                  55                  60                  


Glu His Ile Ala Ala Arg Leu Thr Glu Ala Val His Thr Met Leu Ser 
65                  70                  75                  80  


Ser Pro Leu Glu Tyr Leu Pro Pro Trp Asp Pro Lys Asp Tyr Ser Ala 
                85                  90                  95      


Arg Trp Asn Glu Ile Phe Gly Asn Asn Leu Gly Ala Leu Ala Met Phe 
            100                 105                 110         


Cys Val Leu Tyr Pro Glu Asn Ile Glu Ala Arg Asp Met Ala Lys Asp 
        115                 120                 125             


Tyr Met Glu Arg Met Ala Ala Gln Pro Ser Trp Leu Val Lys Asp Ala 
    130                 135                 140                 


Pro Trp Asp Glu Val Pro Leu Ala His Ser Leu Val Gly Phe Ala Thr 
145                 150                 155                 160 


Ala Tyr Asp Phe Leu Tyr Asn Tyr Leu Ser Lys Thr Gln Gln Glu Lys 
                165                 170                 175     


Phe Leu Glu Val Ile Ala Asn Ala Ser Gly Tyr Met Tyr Glu Thr Ser 
            180                 185                 190         


Tyr Arg Arg Gly Trp Gly Phe Gln Tyr Leu His Asn His Gln Pro Thr 
        195                 200                 205             


Asn Cys Met Ala Leu Leu Thr Gly Ser Leu Val Leu Met Asn Gln Gly 
    210                 215                 220                 


Tyr Leu Gln Glu Ala Tyr Leu Trp Thr Lys Gln Val Leu Thr Ile Met 
225                 230                 235                 240 


Glu Lys Ser Leu Val Leu Leu Arg Glu Val Thr Asp Gly Ser Leu Tyr 
                245                 250                 255     


Glu Gly Val Ala Tyr Gly Ser Tyr Thr Thr Arg Ser Leu Phe Gln Tyr 
            260                 265                 270         


Met Phe Leu Val Gln Arg His Phe Asn Ile Asn His Phe Gly His Pro 
        275                 280                 285             


Trp Leu Lys Gln His Phe Ala Phe Met Tyr Arg Thr Ile Leu Pro Gly 
    290                 295                 300                 


Phe Gln Arg Thr Val Ala Ile Ala Asp Ser Asn Tyr Asn Trp Phe Tyr 
305                 310                 315                 320 


Gly Pro Glu Ser Gln Leu Val Phe Leu Asp Lys Phe Val Met Arg Asn 
                325                 330                 335     


Gly Ser Gly Asn Trp Leu Ala Asp Gln Ile Arg Arg Asn Arg Val Val 
            340                 345                 350         


Glu Gly Pro Gly Thr Pro Ser Lys Gly Gln Arg Trp Cys Thr Leu His 
        355                 360                 365             


Thr Glu Phe Leu Trp Tyr Asp Gly Ser Leu Lys Ser Val Pro Pro Pro 
    370                 375                 380                 


Asp Phe Gly Thr Pro Thr Leu His Tyr Phe Glu Asp Trp Gly Val Val 
385                 390                 395                 400 


Thr Tyr Gly Ser Ala Leu Pro Ala Glu Ile Asn Arg Ser Phe Leu Ser 
                405                 410                 415     


Phe Lys Ser Gly Lys Leu Gly Gly Arg Ala Ile Tyr Asp Ile Val His 
            420                 425                 430         


Arg Asn Lys Tyr Lys Asp Trp Ile Lys Gly Trp Arg Asn Phe Asn Ala 
        435                 440                 445             


Gly His Glu His Pro Asp Gln Asn Ser Phe Thr Phe Ala Pro Asn Gly 
    450                 455                 460                 


Val Pro Phe Ile Thr Glu Ala Leu Tyr Gly Pro Lys Tyr Thr Phe Phe 
465                 470                 475                 480 


Asn Asn Val Leu Met Phe Ser Pro Ala Val Ser Lys Ser Cys Phe Ser 
                485                 490                 495     


Pro Trp Val Gly Gln Val Thr Glu Asp Cys Ser Ser Lys Trp Ser Lys 
            500                 505                 510         


Tyr Lys His Asp Leu Ala Ala Ser Cys Gln Gly Arg Val Val Ala Ala 
        515                 520                 525             


Glu Glu Lys Asn Gly Val Val Phe Ile Arg Gly Glu Gly Val Gly Ala 
    530                 535                 540                 


Tyr Asn Pro Gln Leu Asn Leu Lys Asn Val Gln Arg Asn Leu Ile Leu 
545                 550                 555                 560 


Leu His Pro Gln Leu Leu Leu Leu Val Asp Gln Ile His Leu Gly Glu 
                565                 570                 575     


Glu Ser Pro Leu Glu Thr Ala Ala Ser Phe Phe His Asn Val Asp Val 
            580                 585                 590         


Pro Phe Glu Glu Thr Val Val Asp Gly Val His Gly Ala Phe Ile Arg 
        595                 600                 605             


Gln Arg Asp Gly Leu Tyr Lys Met Tyr Trp Met Asp Asp Thr Gly Tyr 
    610                 615                 620                 


Ser Glu Lys Ala Thr Phe Ala Ser Val Thr Tyr Pro Arg Gly Tyr Pro 
625                 630                 635                 640 


Tyr Asn Gly Thr Asn Tyr Val Asn Val Thr Met His Leu Arg Ser Pro 
                645                 650                 655     


Ile Thr Arg Ala Ala Tyr Leu Phe Ile Gly Pro Ser Ile Asp Val Gln 
            660                 665                 670         


Ser Phe Thr Val His Gly Asp Ser Gln Gln Leu Asp Val Phe Ile Ala 
        675                 680                 685             


Thr Ser Lys His Ala Tyr Ala Thr Tyr Leu Trp Thr Gly Glu Ala Thr 
    690                 695                 700                 


Gly Gln Ser Ala Phe Ala Gln Val Ile Ala Asp Arg His Lys Ile Leu 
705                 710                 715                 720 


Phe Asp Arg Asn Ser Ala Ile Lys Ser Ser Ile Val Pro Glu Val Lys 
                725                 730                 735     


Asp Tyr Ala Ala Ile Val Glu Gln Asn Leu Gln His Phe Lys Pro Val 
            740                 745                 750         


Phe Gln Leu Leu Glu Lys Gln Ile Leu Ser Arg Val Arg Asn Thr Ala 
        755                 760                 765             


Ser Phe Arg Lys Thr Ala Glu Arg Leu Leu Arg Phe Ser Asp Lys Arg 
    770                 775                 780                 


Gln Thr Glu Glu Ala Ile Asp Arg Ile Phe Ala Ile Ser Gln Gln Gln 
785                 790                 795                 800 


Gln Gln Gln Ser Lys Ser Lys Lys Asn Arg Arg Ala Gly Lys Arg Tyr 
                805                 810                 815     


Lys Phe Val Asp Ala Val Pro Asp Ile Phe Ala Gln Ile Glu Val Asn 
            820                 825                 830         


Glu Lys Lys Ile Arg Gln Lys Ala Gln Ile Leu Ala Gln Lys Glu Leu 
        835                 840                 845             


Pro Ile Asp Glu Asp Glu Glu Met Lys Asp Leu Leu Asp Phe Ala Asp 
    850                 855                 860                 


Val Thr Tyr Glu Lys His Lys Asn Gly Gly Leu Ile Lys Gly Arg Phe 
865                 870                 875                 880 


Gly Gln Ala Arg Met Val Thr Thr Thr His Ser Arg Ala Pro Ser Leu 
                885                 890                 895     


Ser Ala Ser Tyr Thr Arg Leu Phe Leu Ile Leu Asn Ile Ala Ile Phe 
            900                 905                 910         


Phe Val Met Leu Ala Met Gln Leu Thr Tyr Phe Gln Arg Ala Gln Ser 
        915                 920                 925             


Leu His Gly Gln Arg Cys Leu Tyr Ala Val Leu Leu Ile Asp Ser Cys 
    930                 935                 940                 


Ile Leu Leu Trp Leu Tyr Ser Ser Cys Ser Gln Ser Gln Cys 
945                 950                 955             


<210>  4446
<211>  1118
<212>  PRT
<213>  Homo Sapiens

<400>  4446

Met Ala Arg Ser Pro Gly Arg Ala Tyr Ala Leu Leu Leu Leu Leu Ile 
1               5                   10                  15      


Cys Phe Asn Val Gly Ser Gly Leu His Leu Gln Val Leu Ser Thr Arg 
            20                  25                  30          


Asn Glu Asn Lys Leu Leu Pro Lys His Pro His Leu Val Arg Gln Lys 
        35                  40                  45              


Arg Ala Trp Ile Thr Ala Pro Val Ala Leu Arg Glu Gly Glu Asp Leu 
    50                  55                  60                  


Ser Lys Lys Asn Pro Ile Ala Lys Ile His Ser Asp Leu Ala Glu Glu 
65                  70                  75                  80  


Arg Gly Leu Lys Ile Thr Tyr Lys Tyr Thr Gly Lys Gly Ile Thr Glu 
                85                  90                  95      


Pro Pro Phe Gly Ile Phe Val Phe Asn Lys Asp Thr Gly Glu Leu Asn 
            100                 105                 110         


Val Thr Ser Ile Leu Asp Arg Glu Glu Thr Pro Phe Phe Leu Leu Thr 
        115                 120                 125             


Gly Tyr Ala Leu Asp Ala Arg Gly Asn Asn Val Glu Lys Pro Leu Glu 
    130                 135                 140                 


Leu Arg Ile Lys Val Leu Asp Ile Asn Asp Asn Glu Pro Val Phe Thr 
145                 150                 155                 160 


Gln Asp Val Phe Val Gly Ser Val Glu Glu Leu Ser Ala Ala His Thr 
                165                 170                 175     


Leu Val Met Lys Ile Asn Ala Thr Asp Ala Asp Glu Pro Asn Thr Leu 
            180                 185                 190         


Asn Ser Lys Ile Ser Tyr Arg Ile Val Ser Leu Glu Pro Ala Tyr Pro 
        195                 200                 205             


Pro Val Phe Tyr Leu Asn Lys Asp Thr Gly Glu Ile Tyr Thr Thr Ser 
    210                 215                 220                 


Val Thr Leu Asp Arg Glu Glu His Ser Ser Tyr Thr Leu Thr Val Glu 
225                 230                 235                 240 


Ala Arg Asp Gly Asn Gly Glu Val Thr Asp Lys Pro Val Lys Gln Ala 
                245                 250                 255     


Gln Val Gln Ile Arg Ile Leu Asp Val Asn Asp Asn Ile Pro Val Val 
            260                 265                 270         


Glu Asn Lys Val Leu Glu Gly Met Val Glu Glu Asn Gln Val Asn Val 
        275                 280                 285             


Glu Val Thr Arg Ile Lys Val Phe Asp Ala Asp Glu Ile Gly Ser Asp 
    290                 295                 300                 


Asn Trp Leu Ala Asn Phe Thr Phe Ala Ser Gly Asn Glu Gly Gly Tyr 
305                 310                 315                 320 


Phe His Ile Glu Thr Asp Ala Gln Thr Asn Glu Gly Ile Val Thr Leu 
                325                 330                 335     


Ile Lys Glu Val Asp Tyr Glu Glu Met Lys Asn Leu Asp Phe Ser Val 
            340                 345                 350         


Ile Val Ala Asn Lys Ala Ala Phe His Lys Ser Ile Arg Ser Lys Tyr 
        355                 360                 365             


Lys Pro Thr Pro Ile Pro Ile Lys Val Lys Val Lys Asn Val Lys Glu 
    370                 375                 380                 


Gly Ile His Phe Lys Ser Ser Val Ile Ser Ile Tyr Val Ser Glu Ser 
385                 390                 395                 400 


Met Asp Arg Ser Ser Lys Gly Gln Ile Ile Gly Asn Phe Gln Ala Phe 
                405                 410                 415     


Asp Glu Asp Thr Gly Leu Pro Ala His Ala Arg Tyr Val Lys Leu Glu 
            420                 425                 430         


Asp Arg Asp Asn Trp Ile Ser Val Asp Ser Val Thr Ser Glu Ile Lys 
        435                 440                 445             


Leu Ala Lys Leu Pro Asp Phe Glu Ser Arg Tyr Val Gln Asn Gly Thr 
    450                 455                 460                 


Tyr Thr Val Lys Ile Val Ala Ile Ser Glu Asp Tyr Pro Arg Lys Thr 
465                 470                 475                 480 


Ile Thr Gly Thr Val Leu Ile Asn Val Glu Asp Ile Asn Asp Asn Cys 
                485                 490                 495     


Pro Thr Leu Ile Glu Pro Val Gln Thr Ile Cys His Asp Ala Glu Tyr 
            500                 505                 510         


Val Asn Val Thr Ala Glu Asp Leu Asp Gly His Pro Asn Ser Gly Pro 
        515                 520                 525             


Phe Ser Phe Ser Val Ile Asp Lys Pro Pro Gly Met Ala Glu Lys Trp 
    530                 535                 540                 


Lys Ile Ala Arg Gln Glu Ser Thr Ser Val Leu Leu Gln Gln Ser Glu 
545                 550                 555                 560 


Lys Lys Leu Gly Arg Ser Glu Ile Gln Phe Leu Ile Ser Asp Asn Gln 
                565                 570                 575     


Gly Phe Ser Cys Pro Glu Lys Gln Val Leu Thr Leu Thr Val Cys Glu 
            580                 585                 590         


Cys Leu His Gly Ser Gly Cys Arg Glu Ala Gln His Asp Ser Tyr Val 
        595                 600                 605             


Gly Leu Gly Pro Ala Ala Ile Ala Leu Met Ile Leu Ala Phe Leu Leu 
    610                 615                 620                 


Leu Leu Leu Val Pro Leu Leu Leu Leu Met Cys His Cys Gly Lys Gly 
625                 630                 635                 640 


Ala Lys Gly Phe Thr Pro Ile Pro Gly Thr Ile Glu Met Leu His Pro 
                645                 650                 655     


Trp Asn Asn Glu Gly Ala Pro Pro Glu Asp Lys Val Val Pro Ser Phe 
            660                 665                 670         


Leu Pro Val Asp Gln Gly Gly Ser Leu Val Gly Arg Asn Gly Val Gly 
        675                 680                 685             


Gly Met Ala Lys Glu Ala Thr Met Lys Gly Ser Ser Ser Ala Ser Ile 
    690                 695                 700                 


Val Lys Gly Gln His Glu Met Ser Glu Met Asp Gly Arg Trp Glu Glu 
705                 710                 715                 720 


His Arg Ser Leu Leu Ser Gly Arg Ala Thr Gln Phe Thr Gly Ala Thr 
                725                 730                 735     


Gly Ala Ile Met Thr Thr Glu Thr Thr Lys Thr Ala Arg Ala Thr Gly 
            740                 745                 750         


Ala Ser Arg Asp Met Ala Gly Ala Gln Ala Ala Ala Val Ala Leu Asn 
        755                 760                 765             


Glu Glu Phe Leu Arg Asn Tyr Phe Thr Asp Lys Ala Ala Ser Tyr Thr 
    770                 775                 780                 


Glu Glu Asp Glu Asn His Thr Ala Lys Asp Cys Leu Leu Val Tyr Ser 
785                 790                 795                 800 


Gln Glu Glu Thr Glu Ser Leu Asn Ala Ser Ile Gly Cys Cys Ser Phe 
                805                 810                 815     


Ile Glu Gly Glu Leu Asp Asp Arg Phe Leu Asp Asp Leu Gly Leu Lys 
            820                 825                 830         


Phe Lys Thr Leu Ala Glu Val Cys Leu Gly Gln Lys Ile Asp Ile Asn 
        835                 840                 845             


Lys Glu Ile Glu Gln Arg Gln Lys Pro Ala Thr Glu Thr Ser Met Asn 
    850                 855                 860                 


Thr Ala Ser His Ser Leu Cys Glu Gln Thr Met Val Asn Ser Glu Asn 
865                 870                 875                 880 


Thr Tyr Ser Ser Gly Ser Ser Phe Pro Val Pro Lys Ser Leu Gln Glu 
                885                 890                 895     


Ala Asn Ala Glu Lys Val Thr Gln Glu Ile Val Thr Glu Arg Ser Val 
            900                 905                 910         


Ser Ser Arg Gln Ala Gln Lys Val Ala Thr Pro Leu Pro Asp Pro Met 
        915                 920                 925             


Ala Ser Arg Asn Val Ile Ala Thr Glu Thr Ser Tyr Val Thr Gly Ser 
    930                 935                 940                 


Thr Met Pro Pro Thr Thr Val Ile Leu Gly Pro Ser Gln Pro Gln Ser 
945                 950                 955                 960 


Leu Ile Val Thr Glu Arg Val Tyr Ala Pro Ala Ser Thr Leu Val Asp 
                965                 970                 975     


Gln Pro Tyr Ala Asn Glu Gly Thr Val Val Val Thr Glu Arg Val Ile 
            980                 985                 990         


Gln Pro His Gly Gly Gly Ser Asn  Pro Leu Glu Gly Thr  Gln His Leu 
        995                 1000                 1005             


Gln Asp  Val Pro Tyr Val Met  Val Arg Glu Arg Glu  Ser Phe Leu 
    1010                 1015                 1020             


Ala Pro  Ser Ser Gly Val Gln  Pro Thr Leu Ala Met  Pro Asn Ile 
    1025                 1030                 1035             


Ala Val  Gly Gln Asn Val Thr  Val Thr Glu Arg Val  Leu Ala Pro 
    1040                 1045                 1050             


Ala Ser  Thr Leu Gln Ser Ser  Tyr Gln Ile Pro Thr  Glu Asn Ser 
    1055                 1060                 1065             


Met Thr  Ala Arg Asn Thr Thr  Val Ser Gly Ala Gly  Val Pro Gly 
    1070                 1075                 1080             


Pro Leu  Pro Asp Phe Gly Leu  Glu Glu Ser Gly His  Ser Asn Ser 
    1085                 1090                 1095             


Thr Ile  Thr Thr Ser Ser Thr  Arg Val Thr Lys His  Ser Thr Val 
    1100                 1105                 1110             


Gln His  Ser Tyr Ser 
    1115             


<210>  4447
<211>  232
<212>  PRT
<213>  Homo Sapiens

<400>  4447

Met Ala Arg Ser Pro Gly Arg Ala Tyr Ala Leu Leu Leu Leu Leu Ile 
1               5                   10                  15      


Cys Phe Asn Val Gly Ser Gly Leu His Leu Gln Val Leu Ser Thr Arg 
            20                  25                  30          


Asn Glu Asn Lys Leu Leu Pro Lys His Pro His Leu Val Arg Gln Lys 
        35                  40                  45              


Arg Ala Trp Ile Thr Ala Pro Val Ala Leu Arg Glu Gly Glu Asp Leu 
    50                  55                  60                  


Ser Lys Lys Asn Pro Ile Ala Lys Ile His Ser Asp Leu Ala Glu Glu 
65                  70                  75                  80  


Arg Gly Leu Lys Ile Thr Tyr Lys Tyr Thr Gly Lys Gly Ile Thr Glu 
                85                  90                  95      


Pro Pro Phe Gly Ile Phe Val Phe Asn Lys Asp Thr Gly Glu Leu Asn 
            100                 105                 110         


Val Thr Ser Ile Leu Asp Arg Glu Glu Thr Pro Phe Phe Leu Leu Thr 
        115                 120                 125             


Gly Tyr Ala Leu Asp Ala Arg Gly Asn Asn Val Glu Lys Pro Leu Glu 
    130                 135                 140                 


Leu Arg Ile Lys Val Leu Asp Ile Asn Asp Asn Glu Pro Val Phe Thr 
145                 150                 155                 160 


Gln Asp Val Phe Val Gly Ser Val Glu Glu Leu Ser Ala Ala His Thr 
                165                 170                 175     


Leu Val Met Lys Ile Asn Ala Thr Asp Ala Asp Glu Pro Asn Thr Leu 
            180                 185                 190         


Asn Ser Lys Ile Ser Tyr Arg Ile Val Ser Leu Glu Pro Ala Tyr Pro 
        195                 200                 205             


Pro Val Phe Tyr Leu Asn Lys Asp Thr Gly Glu Ile Tyr Thr Thr Ser 
    210                 215                 220                 


Val Thr Leu Asp Arg Glu Val Ser 
225                 230         


<210>  4448
<211>  1301
<212>  PRT
<213>  Homo Sapiens

<400>  4448

Met Lys Ile Ile Thr Tyr Phe Cys Ile Trp Ala Val Ala Trp Ala Ile 
1               5                   10                  15      


Pro Val Pro Gln Ser Lys Pro Leu Glu Arg His Val Glu Lys Ser Met 
            20                  25                  30          


Asn Leu His Leu Leu Ala Arg Ser Asn Val Ser Val Gln Asp Glu Leu 
        35                  40                  45              


Asn Ala Ser Gly Thr Ile Lys Glu Ser Gly Val Leu Val His Glu Gly 
    50                  55                  60                  


Asp Arg Gly Arg Gln Glu Asn Thr Gln Asp Gly His Lys Gly Glu Gly 
65                  70                  75                  80  


Asn Gly Ser Lys Trp Ala Glu Val Gly Gly Lys Ser Phe Ser Thr Tyr 
                85                  90                  95      


Ser Thr Leu Ala Asn Glu Glu Gly Asn Ile Glu Gly Trp Asn Gly Asp 
            100                 105                 110         


Thr Gly Lys Ala Glu Thr Tyr Gly His Asp Gly Ile His Gly Lys Glu 
        115                 120                 125             


Glu Asn Ile Thr Ala Asn Gly Ile Gln Gly Gln Val Ser Ile Ile Asp 
    130                 135                 140                 


Asn Ala Gly Ala Thr Asn Arg Ser Asn Thr Asn Gly Asn Thr Asp Lys 
145                 150                 155                 160 


Asn Thr Gln Asn Gly Asp Val Gly Asp Ala Gly His Asn Glu Asp Val 
                165                 170                 175     


Ala Val Val Gln Glu Asp Gly Pro Gln Val Ala Gly Ser Asn Asn Ser 
            180                 185                 190         


Thr Asp Asn Glu Asp Glu Ile Ile Glu Asn Ser Cys Arg Asn Glu Gly 
        195                 200                 205             


Asn Thr Ser Glu Ile Thr Pro Gln Ile Asn Ser Lys Arg Asn Gly Thr 
    210                 215                 220                 


Lys Glu Ala Glu Val Thr Pro Gly Thr Gly Glu Asp Ala Gly Leu Asp 
225                 230                 235                 240 


Asn Ser Asp Gly Ser Pro Ser Gly Asn Gly Ala Asp Glu Asp Glu Asp 
                245                 250                 255     


Glu Gly Ser Gly Asp Asp Glu Asp Glu Glu Ala Gly Asn Gly Lys Asp 
            260                 265                 270         


Ser Ser Asn Asn Ser Lys Gly Gln Glu Gly Gln Asp His Gly Lys Glu 
        275                 280                 285             


Asp Asp His Asp Ser Ser Ile Gly Gln Asn Ser Asp Ser Lys Glu Tyr 
    290                 295                 300                 


Tyr Asp Pro Glu Gly Lys Glu Asp Pro His Asn Glu Val Asp Gly Asp 
305                 310                 315                 320 


Lys Thr Ser Lys Ser Glu Glu Asn Ser Ala Gly Ile Pro Glu Asp Asn 
                325                 330                 335     


Gly Ser Gln Arg Ile Glu Asp Thr Gln Lys Leu Asn His Arg Glu Ser 
            340                 345                 350         


Lys Arg Val Glu Asn Arg Ile Thr Lys Glu Ser Glu Thr His Ala Val 
        355                 360                 365             


Gly Lys Ser Gln Asp Lys Gly Ile Glu Ile Lys Gly Pro Ser Ser Gly 
    370                 375                 380                 


Asn Arg Asn Ile Thr Lys Glu Val Gly Lys Gly Asn Glu Gly Lys Glu 
385                 390                 395                 400 


Asp Lys Gly Gln His Gly Met Ile Leu Gly Lys Gly Asn Val Lys Thr 
                405                 410                 415     


Gln Gly Glu Val Val Asn Ile Glu Gly Pro Gly Gln Lys Ser Glu Pro 
            420                 425                 430         


Gly Asn Lys Val Gly His Ser Asn Thr Gly Ser Asp Ser Asn Ser Asp 
        435                 440                 445             


Gly Tyr Asp Ser Tyr Asp Phe Asp Asp Lys Ser Met Gln Gly Asp Asp 
    450                 455                 460                 


Pro Asn Ser Ser Asp Glu Ser Asn Gly Asn Asp Asp Ala Asn Ser Glu 
465                 470                 475                 480 


Ser Asp Asn Asn Ser Ser Ser Arg Gly Asp Ala Ser Tyr Asn Ser Asp 
                485                 490                 495     


Glu Ser Lys Asp Asn Gly Asn Gly Ser Asp Ser Lys Gly Ala Glu Asp 
            500                 505                 510         


Asp Asp Ser Asp Ser Thr Ser Asp Thr Asn Asn Ser Asp Ser Asn Gly 
        515                 520                 525             


Asn Gly Asn Asn Gly Asn Asp Asp Asn Asp Lys Ser Asp Ser Gly Lys 
    530                 535                 540                 


Gly Lys Ser Asp Ser Ser Asp Ser Asp Ser Ser Asp Ser Ser Asn Ser 
545                 550                 555                 560 


Ser Asp Ser Ser Asp Ser Ser Asp Ser Asp Ser Ser Asp Ser Asn Ser 
                565                 570                 575     


Ser Ser Asp Ser Asp Ser Ser Asp Ser Asp Ser Ser Asp Ser Ser Asp 
            580                 585                 590         


Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser 
        595                 600                 605             


Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Lys Ser 
    610                 615                 620                 


Asp Ser Ser Lys Ser Glu Ser Asp Ser Ser Asp Ser Asp Ser Lys Ser 
625                 630                 635                 640 


Asp Ser Ser Asp Ser Asn Ser Ser Asp Ser Ser Asp Asn Ser Asp Ser 
                645                 650                 655     


Ser Asp Ser Ser Asn Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser 
            660                 665                 670         


Asp Ser Ser Asp Ser Ser Ser Ser Ser Asp Ser Ser Asn Ser Ser Asp 
        675                 680                 685             


Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Glu Ser Ser Asp Ser 
    690                 695                 700                 


Ser Asp Ser Ser Asp Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn 
705                 710                 715                 720 


Ser Asn Ser Ser Asp Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp 
                725                 730                 735     


Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser 
            740                 745                 750         


Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser 
        755                 760                 765             


Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp 
    770                 775                 780                 


Ser Asn Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser 
785                 790                 795                 800 


Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser 
                805                 810                 815     


Asp Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser 
            820                 825                 830         


Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser 
        835                 840                 845             


Asp Gly Ser Asp Ser Asp Ser Ser Asn Arg Ser Asp Ser Ser Asn Ser 
    850                 855                 860                 


Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser 
865                 870                 875                 880 


Asp Ser Ser Asp Ser Asn Glu Ser Ser Asn Ser Ser Asp Ser Ser Asp 
                885                 890                 895     


Ser Ser Asn Ser Ser Asp Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser 
            900                 905                 910         


Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Glu Ser Ser Asn 
        915                 920                 925             


Ser Ser Asp Asn Ser Asn Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser 
    930                 935                 940                 


Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asn Ser Ser 
945                 950                 955                 960 


Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Asn Ser Ser Asp Ser 
                965                 970                 975     


Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser 
            980                 985                 990         


Asp Ser Ser Asp Ser Ser Asp Ser  Ser Asn Ser Ser Asp  Ser Ser Asp 
        995                 1000                 1005             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asn Ser Ser Asp  Ser Ser Asn 
    1010                 1015                 1020             


Ser Ser  Asp Ser Ser Asn Ser  Ser Asp Ser Ser Asp  Ser Ser Asp 
    1025                 1030                 1035             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Ser Asp 
    1040                 1045                 1050             


Ser Ser  Asn Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Ser Asp 
    1055                 1060                 1065             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Ser Glu 
    1070                 1075                 1080             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asn Ser Ser Asp  Ser Ser Asp 
    1085                 1090                 1095             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Ser Asp 
    1100                 1105                 1110             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asn Ser Ser Asp  Ser Ser Asp 
    1115                 1120                 1125             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asn  Ser Ser Asp 
    1130                 1135                 1140             


Ser Ser  Asp Ser Ser Glu Ser  Ser Asp Ser Ser Asp  Ser Ser Asp 
    1145                 1150                 1155             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Ser Asp 
    1160                 1165                 1170             


Ser Ser  Asp Ser Ser Asn Ser  Ser Asp Ser Ser Asp  Ser Ser Asp 
    1175                 1180                 1185             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Ser Asp 
    1190                 1195                 1200             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Ser Asp 
    1205                 1210                 1215             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Asn Glu 
    1220                 1225                 1230             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Ser Asn 
    1235                 1240                 1245             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Thr Ser 
    1250                 1255                 1260             


Asp Ser  Asn Asp Glu Ser Asp  Ser Gln Ser Lys Ser  Gly Asn Gly 
    1265                 1270                 1275             


Asn Asn  Asn Gly Ser Asp Ser  Asp Ser Asp Ser Glu  Gly Ser Asp 
    1280                 1285                 1290             


Ser Asn  His Ser Thr Ser Asp  Asp 
    1295                 1300     


<210>  4449
<211>  1301
<212>  PRT
<213>  Homo Sapiens

<400>  4449

Met Lys Ile Ile Thr Tyr Phe Cys Ile Trp Ala Val Ala Trp Ala Ile 
1               5                   10                  15      


Pro Val Pro Gln Ser Lys Pro Leu Glu Arg His Val Glu Lys Ser Met 
            20                  25                  30          


Asn Leu His Leu Leu Ala Arg Ser Asn Val Ser Val Gln Asp Glu Leu 
        35                  40                  45              


Asn Ala Ser Gly Thr Ile Lys Glu Ser Gly Val Leu Val His Glu Gly 
    50                  55                  60                  


Asp Arg Gly Arg Gln Glu Asn Thr Gln Asp Gly His Lys Gly Glu Gly 
65                  70                  75                  80  


Asn Gly Ser Lys Trp Ala Glu Val Gly Gly Lys Ser Phe Ser Thr Tyr 
                85                  90                  95      


Ser Thr Leu Ala Asn Glu Glu Gly Asn Ile Glu Gly Trp Asn Gly Asp 
            100                 105                 110         


Thr Gly Lys Ala Glu Thr Tyr Gly His Asp Gly Ile His Gly Lys Glu 
        115                 120                 125             


Glu Asn Ile Thr Ala Asn Gly Ile Gln Gly Gln Val Ser Ile Ile Asp 
    130                 135                 140                 


Asn Ala Gly Ala Thr Asn Arg Ser Asn Thr Asn Gly Asn Thr Asp Lys 
145                 150                 155                 160 


Asn Thr Gln Asn Gly Asp Val Gly Asp Ala Gly His Asn Glu Asp Val 
                165                 170                 175     


Ala Val Val Gln Glu Asp Gly Pro Gln Val Ala Gly Ser Asn Asn Ser 
            180                 185                 190         


Thr Asp Asn Glu Asp Glu Ile Ile Glu Asn Ser Cys Arg Asn Glu Gly 
        195                 200                 205             


Asn Thr Ser Glu Ile Thr Pro Gln Ile Asn Ser Lys Arg Asn Gly Thr 
    210                 215                 220                 


Lys Glu Ala Glu Val Thr Pro Gly Thr Gly Glu Asp Ala Gly Leu Asp 
225                 230                 235                 240 


Asn Ser Asp Gly Ser Pro Ser Gly Asn Gly Ala Asp Glu Asp Glu Asp 
                245                 250                 255     


Glu Gly Ser Gly Asp Asp Glu Asp Glu Glu Ala Gly Asn Gly Lys Asp 
            260                 265                 270         


Ser Ser Asn Asn Ser Lys Gly Gln Glu Gly Gln Asp His Gly Lys Glu 
        275                 280                 285             


Asp Asp His Asp Ser Ser Ile Gly Gln Asn Ser Asp Ser Lys Glu Tyr 
    290                 295                 300                 


Tyr Asp Pro Glu Gly Lys Glu Asp Pro His Asn Glu Val Asp Gly Asp 
305                 310                 315                 320 


Lys Thr Ser Lys Ser Glu Glu Asn Ser Ala Gly Ile Pro Glu Asp Asn 
                325                 330                 335     


Gly Ser Gln Arg Ile Glu Asp Thr Gln Lys Leu Asn His Arg Glu Ser 
            340                 345                 350         


Lys Arg Val Glu Asn Arg Ile Thr Lys Glu Ser Glu Thr His Ala Val 
        355                 360                 365             


Gly Lys Ser Gln Asp Lys Gly Ile Glu Ile Lys Gly Pro Ser Ser Gly 
    370                 375                 380                 


Asn Arg Asn Ile Thr Lys Glu Val Gly Lys Gly Asn Glu Gly Lys Glu 
385                 390                 395                 400 


Asp Lys Gly Gln His Gly Met Ile Leu Gly Lys Gly Asn Val Lys Thr 
                405                 410                 415     


Gln Gly Glu Val Val Asn Ile Glu Gly Pro Gly Gln Lys Ser Glu Pro 
            420                 425                 430         


Gly Asn Lys Val Gly His Ser Asn Thr Gly Ser Asp Ser Asn Ser Asp 
        435                 440                 445             


Gly Tyr Asp Ser Tyr Asp Phe Asp Asp Lys Ser Met Gln Gly Asp Asp 
    450                 455                 460                 


Pro Asn Ser Ser Asp Glu Ser Asn Gly Asn Asp Asp Ala Asn Ser Glu 
465                 470                 475                 480 


Ser Asp Asn Asn Ser Ser Ser Arg Gly Asp Ala Ser Tyr Asn Ser Asp 
                485                 490                 495     


Glu Ser Lys Asp Asn Gly Asn Gly Ser Asp Ser Lys Gly Ala Glu Asp 
            500                 505                 510         


Asp Asp Ser Asp Ser Thr Ser Asp Thr Asn Asn Ser Asp Ser Asn Gly 
        515                 520                 525             


Asn Gly Asn Asn Gly Asn Asp Asp Asn Asp Lys Ser Asp Ser Gly Lys 
    530                 535                 540                 


Gly Lys Ser Asp Ser Ser Asp Ser Asp Ser Ser Asp Ser Ser Asn Ser 
545                 550                 555                 560 


Ser Asp Ser Ser Asp Ser Ser Asp Ser Asp Ser Ser Asp Ser Asn Ser 
                565                 570                 575     


Ser Ser Asp Ser Asp Ser Ser Asp Ser Asp Ser Ser Asp Ser Ser Asp 
            580                 585                 590         


Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser 
        595                 600                 605             


Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Lys Ser 
    610                 615                 620                 


Asp Ser Ser Lys Ser Glu Ser Asp Ser Ser Asp Ser Asp Ser Lys Ser 
625                 630                 635                 640 


Asp Ser Ser Asp Ser Asn Ser Ser Asp Ser Ser Asp Asn Ser Asp Ser 
                645                 650                 655     


Ser Asp Ser Ser Asn Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser 
            660                 665                 670         


Asp Ser Ser Asp Ser Ser Ser Ser Ser Asp Ser Ser Asn Ser Ser Asp 
        675                 680                 685             


Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Glu Ser Ser Asp Ser 
    690                 695                 700                 


Ser Asp Ser Ser Asp Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn 
705                 710                 715                 720 


Ser Asn Ser Ser Asp Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp 
                725                 730                 735     


Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser 
            740                 745                 750         


Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser 
        755                 760                 765             


Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp 
    770                 775                 780                 


Ser Asn Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser 
785                 790                 795                 800 


Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser 
                805                 810                 815     


Asp Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser 
            820                 825                 830         


Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser 
        835                 840                 845             


Asp Gly Ser Asp Ser Asp Ser Ser Asn Arg Ser Asp Ser Ser Asn Ser 
    850                 855                 860                 


Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser 
865                 870                 875                 880 


Asp Ser Ser Asp Ser Asn Glu Ser Ser Asn Ser Ser Asp Ser Ser Asp 
                885                 890                 895     


Ser Ser Asn Ser Ser Asp Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser 
            900                 905                 910         


Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Glu Ser Ser Asn 
        915                 920                 925             


Ser Ser Asp Asn Ser Asn Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser 
    930                 935                 940                 


Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asn Ser Ser 
945                 950                 955                 960 


Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Asn Ser Ser Asp Ser 
                965                 970                 975     


Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser 
            980                 985                 990         


Asp Ser Ser Asp Ser Ser Asp Ser  Ser Asn Ser Ser Asp  Ser Ser Asp 
        995                 1000                 1005             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asn Ser Ser Asp  Ser Ser Asn 
    1010                 1015                 1020             


Ser Ser  Asp Ser Ser Asn Ser  Ser Asp Ser Ser Asp  Ser Ser Asp 
    1025                 1030                 1035             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Ser Asp 
    1040                 1045                 1050             


Ser Ser  Asn Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Ser Asp 
    1055                 1060                 1065             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Ser Glu 
    1070                 1075                 1080             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asn Ser Ser Asp  Ser Ser Asp 
    1085                 1090                 1095             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Ser Asp 
    1100                 1105                 1110             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asn Ser Ser Asp  Ser Ser Asp 
    1115                 1120                 1125             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asn  Ser Ser Asp 
    1130                 1135                 1140             


Ser Ser  Asp Ser Ser Glu Ser  Ser Asp Ser Ser Asp  Ser Ser Asp 
    1145                 1150                 1155             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Ser Asp 
    1160                 1165                 1170             


Ser Ser  Asp Ser Ser Asn Ser  Ser Asp Ser Ser Asp  Ser Ser Asp 
    1175                 1180                 1185             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Ser Asp 
    1190                 1195                 1200             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Ser Asp 
    1205                 1210                 1215             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Asn Glu 
    1220                 1225                 1230             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Ser Asn 
    1235                 1240                 1245             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Thr Ser 
    1250                 1255                 1260             


Asp Ser  Asn Asp Glu Ser Asp  Ser Gln Ser Lys Ser  Gly Asn Gly 
    1265                 1270                 1275             


Asn Asn  Asn Gly Ser Asp Ser  Asp Ser Asp Ser Glu  Gly Ser Asp 
    1280                 1285                 1290             


Ser Asn  His Ser Thr Ser Asp  Asp 
    1295                 1300     


<210>  4450
<211>  123
<212>  PRT
<213>  Homo Sapiens

<400>  4450

Glu Met Thr Arg Lys Gln Pro Asp Val Asp Lys Val Thr Lys Thr Tyr 
1               5                   10                  15      


Lys Arg Arg Ala Ala Asp Pro Ser Ser Leu Gln Ser His Ile Pro Val 
            20                  25                  30          


Leu Asp Lys Gly Arg Ala Gly Arg Lys Arg Phe Pro Ala Ser Ser Leu 
        35                  40                  45              


Tyr Pro Ser Gly Ser Gln Thr Gln Ile Glu Thr Lys Asn Pro Arg Val 
    50                  55                  60                  


Asn Leu Leu Val Ser Lys Trp Gln Gln Val Trp Leu Leu Ala Leu Glu 
65                  70                  75                  80  


Arg Arg Arg Lys Leu Asn Asp Ala Leu Asp Arg Leu Glu Glu Val Trp 
                85                  90                  95      


Lys Phe Ile Pro Ser Thr Pro His Cys His Leu Pro Ser Phe Leu Ile 
            100                 105                 110         


Thr His Cys His Cys Gln Asn Leu Gly Ile Phe 
        115                 120             


<210>  4451
<211>  7461
<212>  PRT
<213>  Homo Sapiens

<400>  4451

Met Ala Gly Tyr Leu Ser Pro Ala Ala Tyr Leu Tyr Val Glu Glu Gln 
1               5                   10                  15      


Glu Tyr Leu Gln Ala Tyr Glu Asp Val Leu Glu Arg Tyr Lys Asp Glu 
            20                  25                  30          


Arg Asp Lys Val Gln Lys Lys Thr Phe Thr Lys Trp Ile Asn Gln His 
        35                  40                  45              


Leu Met Lys Val Arg Lys His Val Asn Asp Leu Tyr Glu Asp Leu Arg 
    50                  55                  60                  


Asp Gly His Asn Leu Ile Ser Leu Leu Glu Val Leu Ser Gly Asp Thr 
65                  70                  75                  80  


Leu Pro Arg Glu Lys Gly Arg Met Arg Phe His Arg Leu Gln Asn Val 
                85                  90                  95      


Gln Ile Ala Leu Asp Tyr Leu Lys Arg Arg Gln Val Lys Leu Val Asn 
            100                 105                 110         


Ile Arg Asn Asp Asp Ile Thr Asp Gly Asn Pro Lys Leu Thr Leu Gly 
        115                 120                 125             


Leu Ile Trp Thr Ile Ile Leu His Phe Gln Ile Ser Asp Ile His Val 
    130                 135                 140                 


Thr Gly Glu Ser Glu Asp Met Ser Ala Lys Glu Arg Leu Leu Leu Trp 
145                 150                 155                 160 


Thr Gln Gln Ala Thr Glu Gly Tyr Ala Gly Ile Arg Cys Glu Asn Phe 
                165                 170                 175     


Thr Thr Cys Trp Arg Asp Gly Lys Leu Phe Asn Ala Ile Ile His Lys 
            180                 185                 190         


Tyr Arg Pro Asp Leu Ile Asp Met Asn Thr Val Ala Val Gln Ser Asn 
        195                 200                 205             


Leu Ala Asn Leu Glu His Ala Phe Tyr Val Ala Glu Lys Ile Gly Val 
    210                 215                 220                 


Ile Arg Leu Leu Asp Pro Glu Asp Val Asp Val Ser Ser Pro Asp Glu 
225                 230                 235                 240 


Lys Ser Val Ile Thr Tyr Val Ser Ser Leu Tyr Asp Ala Phe Pro Lys 
                245                 250                 255     


Val Pro Glu Gly Gly Glu Gly Ile Gly Ala Asn Asp Val Glu Val Lys 
            260                 265                 270         


Trp Ile Glu Tyr Gln Asn Met Val Asn Tyr Leu Ile Gln Trp Ile Arg 
        275                 280                 285             


His His Val Thr Thr Met Ser Glu Arg Thr Phe Pro Asn Asn Pro Val 
    290                 295                 300                 


Glu Leu Lys Ala Leu Tyr Asn Gln Tyr Leu Gln Phe Lys Glu Thr Glu 
305                 310                 315                 320 


Ile Pro Pro Lys Glu Thr Glu Lys Ser Lys Ile Lys Arg Leu Tyr Lys 
                325                 330                 335     


Leu Leu Glu Ile Trp Ile Glu Phe Gly Arg Ile Lys Leu Leu Gln Gly 
            340                 345                 350         


Tyr His Pro Asn Asp Ile Glu Lys Glu Trp Gly Lys Leu Ile Ile Ala 
        355                 360                 365             


Met Leu Glu Arg Glu Lys Ala Leu Arg Pro Glu Val Glu Arg Leu Glu 
    370                 375                 380                 


Met Leu Gln Gln Ile Ala Asn Arg Val Gln Arg Asp Ser Val Ile Cys 
385                 390                 395                 400 


Glu Asp Lys Leu Ile Leu Ala Gly Asn Ala Leu Gln Ser Asp Ser Lys 
                405                 410                 415     


Arg Leu Glu Ser Gly Val Gln Phe Gln Asn Glu Ala Glu Ile Ala Gly 
            420                 425                 430         


Tyr Ile Leu Glu Cys Glu Asn Leu Leu Arg Gln His Val Ile Asp Val 
        435                 440                 445             


Gln Ile Leu Ile Asp Gly Lys Tyr Tyr Gln Ala Asp Gln Leu Val Gln 
    450                 455                 460                 


Arg Val Ala Lys Leu Arg Asp Glu Ile Met Ala Leu Arg Asn Glu Cys 
465                 470                 475                 480 


Ser Ser Val Tyr Ser Lys Gly Arg Ile Leu Thr Thr Glu Gln Thr Lys 
                485                 490                 495     


Leu Met Ile Ser Gly Ile Thr Gln Ser Leu Asn Ser Gly Phe Ala Gln 
            500                 505                 510         


Thr Leu His Pro Ser Leu Thr Ser Gly Leu Thr Gln Ser Leu Thr Pro 
        515                 520                 525             


Ser Leu Thr Ser Ser Ser Met Thr Ser Gly Leu Ser Ser Gly Met Thr 
    530                 535                 540                 


Ser Arg Leu Thr Pro Ser Val Thr Pro Ala Tyr Thr Pro Gly Phe Pro 
545                 550                 555                 560 


Ser Gly Leu Val Pro Asn Phe Ser Ser Gly Val Glu Pro Asn Ser Leu 
                565                 570                 575     


Gln Thr Leu Lys Leu Met Gln Ile Arg Lys Pro Leu Leu Lys Ser Ser 
            580                 585                 590         


Leu Leu Asp Gln Asn Leu Thr Glu Glu Glu Ile Asn Met Lys Phe Val 
        595                 600                 605             


Gln Asp Leu Leu Asn Trp Val Asp Glu Met Gln Val Gln Leu Asp Arg 
    610                 615                 620                 


Thr Glu Trp Gly Ser Asp Leu Pro Ser Val Glu Ser His Leu Glu Asn 
625                 630                 635                 640 


His Lys Asn Val His Arg Ala Ile Glu Glu Phe Glu Ser Ser Leu Lys 
                645                 650                 655     


Glu Ala Lys Ile Ser Glu Ile Gln Met Thr Ala Pro Leu Lys Leu Thr 
            660                 665                 670         


Tyr Ala Glu Lys Leu His Arg Leu Glu Ser Gln Tyr Ala Lys Leu Leu 
        675                 680                 685             


Asn Thr Ser Arg Asn Gln Glu Arg His Leu Asp Thr Leu His Asn Phe 
    690                 695                 700                 


Val Ser Arg Ala Thr Asn Glu Leu Ile Trp Leu Asn Glu Lys Glu Glu 
705                 710                 715                 720 


Glu Glu Val Ala Tyr Asp Trp Ser Glu Arg Asn Thr Asn Ile Ala Arg 
                725                 730                 735     


Lys Lys Asp Tyr His Ala Glu Leu Met Arg Glu Leu Asp Gln Lys Glu 
            740                 745                 750         


Glu Asn Ile Lys Ser Val Gln Glu Ile Ala Glu Gln Leu Leu Leu Glu 
        755                 760                 765             


Asn His Pro Ala Arg Leu Thr Ile Glu Ala Tyr Arg Ala Ala Met Gln 
    770                 775                 780                 


Thr Gln Trp Ser Trp Ile Leu Gln Leu Cys Gln Cys Val Glu Gln His 
785                 790                 795                 800 


Ile Lys Glu Asn Thr Ala Tyr Phe Glu Phe Phe Asn Asp Ala Lys Glu 
                805                 810                 815     


Ala Thr Asp Tyr Leu Arg Asn Leu Lys Asp Ala Ile Gln Arg Lys Tyr 
            820                 825                 830         


Ser Cys Asp Arg Ser Ser Ser Ile His Lys Leu Glu Asp Leu Val Gln 
        835                 840                 845             


Glu Ser Met Glu Glu Lys Glu Glu Leu Leu Gln Tyr Lys Ser Thr Ile 
    850                 855                 860                 


Ala Asn Leu Met Gly Lys Ala Lys Thr Ile Ile Gln Leu Lys Pro Arg 
865                 870                 875                 880 


Asn Ser Asp Cys Pro Leu Lys Thr Ser Ile Pro Ile Lys Ala Ile Cys 
                885                 890                 895     


Asp Tyr Arg Gln Ile Glu Ile Thr Ile Tyr Lys Asp Asp Glu Cys Val 
            900                 905                 910         


Leu Ala Asn Asn Ser His Arg Ala Lys Trp Lys Val Ile Ser Pro Thr 
        915                 920                 925             


Gly Asn Glu Ala Met Val Pro Ser Val Cys Phe Thr Val Pro Pro Pro 
    930                 935                 940                 


Asn Lys Glu Ala Val Asp Leu Ala Asn Arg Ile Glu Gln Gln Tyr Gln 
945                 950                 955                 960 


Asn Val Leu Thr Leu Trp His Glu Ser His Ile Asn Met Lys Ser Val 
                965                 970                 975     


Val Ser Trp His Tyr Leu Ile Asn Glu Ile Asp Arg Ile Arg Ala Ser 
            980                 985                 990         


Asn Val Ala Ser Ile Lys Thr Met  Leu Pro Gly Glu His  Gln Gln Val 
        995                 1000                 1005             


Leu Ser  Asn Leu Gln Ser Arg  Phe Glu Asp Phe Leu  Glu Asp Ser 
    1010                 1015                 1020             


Gln Glu  Ser Gln Val Phe Ser  Gly Ser Asp Ile Thr  Gln Leu Glu 
    1025                 1030                 1035             


Lys Glu  Val Asn Val Cys Lys  Gln Tyr Tyr Gln Glu  Leu Leu Lys 
    1040                 1045                 1050             


Ser Ala  Glu Arg Glu Glu Gln  Glu Glu Ser Val Tyr  Asn Leu Tyr 
    1055                 1060                 1065             


Ile Ser  Glu Val Arg Asn Ile  Arg Leu Arg Leu Glu  Asn Cys Glu 
    1070                 1075                 1080             


Asp Arg  Leu Ile Arg Gln Ile  Arg Thr Pro Leu Glu  Arg Asp Asp 
    1085                 1090                 1095             


Leu His  Glu Ser Val Phe Arg  Ile Thr Glu Gln Glu  Lys Leu Lys 
    1100                 1105                 1110             


Lys Glu  Leu Glu Arg Leu Lys  Asp Asp Leu Gly Thr  Ile Thr Asn 
    1115                 1120                 1125             


Lys Cys  Glu Glu Phe Phe Ser  Gln Ala Ala Ala Ser  Ser Ser Val 
    1130                 1135                 1140             


Pro Thr  Leu Arg Ser Glu Leu  Asn Val Val Leu Gln  Asn Met Asn 
    1145                 1150                 1155             


Gln Val  Tyr Ser Met Ser Ser  Thr Tyr Ile Asp Lys  Leu Lys Thr 
    1160                 1165                 1170             


Val Asn  Leu Val Leu Lys Asn  Thr Gln Ala Ala Glu  Ala Leu Val 
    1175                 1180                 1185             


Lys Leu  Tyr Glu Thr Lys Leu  Cys Glu Glu Glu Ala  Val Ile Ala 
    1190                 1195                 1200             


Asp Lys  Asn Asn Ile Glu Asn  Leu Ile Ser Thr Leu  Lys Gln Trp 
    1205                 1210                 1215             


Arg Ser  Glu Val Asp Glu Lys  Arg Gln Val Phe His  Ala Leu Glu 
    1220                 1225                 1230             


Asp Glu  Leu Gln Lys Ala Lys  Ala Ile Ser Asp Glu  Met Phe Lys 
    1235                 1240                 1245             


Thr Tyr  Lys Glu Arg Asp Leu  Asp Phe Asp Trp His  Lys Glu Lys 
    1250                 1255                 1260             


Ala Asp  Gln Leu Val Glu Arg  Trp Gln Asn Val His  Val Gln Ile 
    1265                 1270                 1275             


Asp Asn  Arg Leu Arg Asp Leu  Glu Gly Ile Gly Lys  Ser Leu Lys 
    1280                 1285                 1290             


Tyr Tyr  Arg Asp Thr Tyr His  Pro Leu Asp Asp Trp  Ile Gln Gln 
    1295                 1300                 1305             


Val Glu  Thr Thr Gln Arg Lys  Ile Gln Glu Asn Gln  Pro Glu Asn 
    1310                 1315                 1320             


Ser Lys  Thr Leu Ala Thr Gln  Leu Asn Gln Gln Lys  Met Leu Val 
    1325                 1330                 1335             


Ser Glu  Ile Glu Met Lys Gln  Ser Lys Met Asp Glu  Cys Gln Lys 
    1340                 1345                 1350             


Tyr Ala  Glu Gln Tyr Ser Ala  Thr Val Lys Asp Tyr  Glu Leu Gln 
    1355                 1360                 1365             


Thr Met  Thr Tyr Arg Ala Met  Val Asp Ser Gln Gln  Lys Ser Pro 
    1370                 1375                 1380             


Val Lys  Arg Arg Arg Met Gln  Ser Ser Ala Asp Leu  Ile Ile Gln 
    1385                 1390                 1395             


Glu Phe  Met Asp Leu Arg Thr  Arg Tyr Thr Ala Leu  Val Thr Leu 
    1400                 1405                 1410             


Met Thr  Gln Tyr Ile Lys Phe  Ala Gly Asp Ser Leu  Lys Arg Leu 
    1415                 1420                 1425             


Glu Glu  Glu Glu Lys Ser Leu  Glu Glu Glu Lys Lys  Glu His Val 
    1430                 1435                 1440             


Glu Lys  Ala Lys Glu Leu Gln  Lys Trp Val Ser Asn  Ile Ser Lys 
    1445                 1450                 1455             


Thr Leu  Lys Asp Ala Glu Lys  Ala Gly Lys Pro Pro  Phe Ser Lys 
    1460                 1465                 1470             


Gln Lys  Ile Ser Ser Glu Glu  Ile Ser Thr Lys Lys  Glu Gln Leu 
    1475                 1480                 1485             


Ser Glu  Ala Leu Gln Thr Ile  Gln Leu Phe Leu Ala  Lys His Gly 
    1490                 1495                 1500             


Asp Lys  Met Thr Asp Glu Glu  Arg Asn Glu Leu Glu  Lys Gln Val 
    1505                 1510                 1515             


Lys Thr  Leu Gln Glu Ser Tyr  Asn Leu Leu Phe Ser  Glu Ser Leu 
    1520                 1525                 1530             


Lys Gln  Leu Gln Glu Ser Gln  Thr Ser Gly Asp Val  Lys Val Glu 
    1535                 1540                 1545             


Glu Lys  Leu Asp Lys Val Ile  Ala Gly Thr Ile Asp  Gln Thr Thr 
    1550                 1555                 1560             


Gly Glu  Val Leu Ser Val Phe  Gln Ala Val Leu Arg  Gly Leu Ile 
    1565                 1570                 1575             


Asp Tyr  Asp Thr Gly Ile Arg  Leu Leu Glu Thr Gln  Leu Met Ile 
    1580                 1585                 1590             


Ser Gly  Leu Ile Ser Pro Glu  Leu Arg Lys Cys Phe  Asp Leu Lys 
    1595                 1600                 1605             


Asp Ala  Lys Ser His Gly Leu  Ile Asp Glu Gln Ile  Leu Cys Gln 
    1610                 1615                 1620             


Leu Lys  Glu Leu Ser Lys Ala  Lys Glu Ile Ile Ser  Ala Ala Ser 
    1625                 1630                 1635             


Pro Thr  Thr Ile Pro Val Leu  Asp Ala Leu Ala Gln  Ser Met Ile 
    1640                 1645                 1650             


Thr Glu  Ser Met Ala Ile Lys  Val Leu Glu Ile Leu  Leu Ser Thr 
    1655                 1660                 1665             


Gly Ser  Leu Val Ile Pro Ala  Thr Gly Glu Gln Leu  Thr Leu Gln 
    1670                 1675                 1680             


Lys Ala  Phe Gln Gln Asn Leu  Val Ser Ser Ala Leu  Phe Ser Lys 
    1685                 1690                 1695             


Val Leu  Glu Arg Gln Asn Met  Cys Lys Asp Leu Ile  Asp Pro Cys 
    1700                 1705                 1710             


Thr Ser  Glu Lys Val Ser Leu  Ile Asp Met Val Gln  Arg Ser Thr 
    1715                 1720                 1725             


Leu Gln  Glu Asn Thr Gly Met  Trp Leu Leu Pro Val  Arg Pro Gln 
    1730                 1735                 1740             


Glu Gly  Gly Arg Ile Thr Leu  Lys Cys Gly Arg Asn  Ile Ser Ile 
    1745                 1750                 1755             


Leu Arg  Ala Ala His Glu Gly  Leu Ile Asp Arg Glu  Thr Met Phe 
    1760                 1765                 1770             


Arg Leu  Leu Ser Ala Gln Leu  Leu Ser Gly Gly Leu  Ile Asn Ser 
    1775                 1780                 1785             


Asn Ser  Gly Gln Arg Met Thr  Val Glu Glu Ala Val  Arg Glu Gly 
    1790                 1795                 1800             


Val Ile  Asp Arg Asp Thr Ala  Ser Ser Ile Leu Thr  Tyr Gln Val 
    1805                 1810                 1815             


Gln Thr  Gly Gly Ile Ile Gln  Ser Asn Pro Ala Lys  Arg Leu Thr 
    1820                 1825                 1830             


Val Asp  Glu Ala Val Gln Cys  Asp Leu Ile Thr Ser  Ser Ser Ala 
    1835                 1840                 1845             


Leu Leu  Val Leu Glu Ala Gln  Arg Gly Tyr Val Gly  Leu Ile Trp 
    1850                 1855                 1860             


Pro His  Ser Gly Glu Ile Phe  Pro Thr Ser Ser Ser  Leu Gln Gln 
    1865                 1870                 1875             


Glu Leu  Ile Thr Asn Glu Leu  Ala Tyr Lys Ile Leu  Asn Gly Arg 
    1880                 1885                 1890             


Gln Lys  Ile Ala Ala Leu Tyr  Ile Pro Glu Ser Ser  Gln Val Ile 
    1895                 1900                 1905             


Gly Leu  Asp Ala Ala Lys Gln  Leu Gly Ile Ile Asp  Asn Asn Thr 
    1910                 1915                 1920             


Ala Ser  Ile Leu Lys Asn Ile  Thr Leu Pro Asp Lys  Met Pro Asp 
    1925                 1930                 1935             


Leu Gly  Asp Leu Glu Ala Cys  Lys Asn Ala Arg Arg  Trp Leu Ser 
    1940                 1945                 1950             


Phe Cys  Lys Phe Gln Pro Ser  Thr Val His Asp Tyr  Arg Gln Glu 
    1955                 1960                 1965             


Glu Asp  Val Phe Asp Gly Glu  Glu Pro Val Thr Thr  Gln Thr Ser 
    1970                 1975                 1980             


Glu Glu  Thr Lys Lys Leu Phe  Leu Ser Tyr Leu Met  Ile Asn Ser 
    1985                 1990                 1995             


Tyr Met  Asp Ala Asn Thr Gly  Gln Arg Leu Leu Leu  Tyr Asp Gly 
    2000                 2005                 2010             


Asp Leu  Asp Glu Ala Val Gly  Met Leu Leu Glu Gly  Cys His Ala 
    2015                 2020                 2025             


Glu Phe  Asp Gly Asn Thr Ala  Ile Lys Glu Cys Leu  Asp Val Leu 
    2030                 2035                 2040             


Ser Ser  Ser Gly Val Phe Leu  Asn Asn Ala Ser Gly  Arg Glu Lys 
    2045                 2050                 2055             


Asp Glu  Cys Thr Ala Thr Pro  Ser Ser Phe Asn Lys  Cys His Cys 
    2060                 2065                 2070             


Gly Glu  Pro Glu His Glu Glu  Thr Pro Glu Asn Arg  Lys Cys Ala 
    2075                 2080                 2085             


Ile Asp  Glu Glu Phe Asn Glu  Met Arg Asn Thr Val  Ile Asn Ser 
    2090                 2095                 2100             


Glu Phe  Ser Gln Ser Gly Lys  Leu Ala Ser Thr Ile  Ser Ile Asp 
    2105                 2110                 2115             


Pro Lys  Val Asn Ser Ser Pro  Ser Val Cys Val Pro  Ser Leu Ile 
    2120                 2125                 2130             


Ser Tyr  Leu Thr Gln Thr Glu  Leu Ala Asp Ile Ser  Met Leu Arg 
    2135                 2140                 2145             


Ser Asp  Ser Glu Asn Ile Leu  Thr Asn Tyr Glu Asn  Gln Ser Arg 
    2150                 2155                 2160             


Val Glu  Thr Asn Glu Arg Ala  Asn Glu Cys Ser His  Ser Lys Asn 
    2165                 2170                 2175             


Ile Gln  Asn Phe Pro Ser Asp  Leu Ile Glu Asn Pro  Ile Met Lys 
    2180                 2185                 2190             


Ser Lys  Met Ser Lys Phe Cys  Gly Val Asn Glu Thr  Glu Asn Glu 
    2195                 2200                 2205             


Asp Asn  Thr Asn Arg Asp Ser  Pro Ile Phe Asp Tyr  Ser Pro Arg 
    2210                 2215                 2220             


Leu Ser  Ala Leu Leu Ser His  Asp Lys Leu Met His  Ser Gln Gly 
    2225                 2230                 2235             


Ser Phe  Asn Asp Thr His Thr  Pro Glu Ser Asn Gly  Asn Lys Cys 
    2240                 2245                 2250             


Glu Ala  Pro Ala Leu Ser Phe  Ser Asp Lys Thr Met  Leu Ser Gly 
    2255                 2260                 2265             


Gln Arg  Ile Gly Glu Lys Phe  Gln Asp Gln Phe Leu  Gly Ile Ala 
    2270                 2275                 2280             


Ala Ile  Asn Ile Ser Leu Pro  Gly Glu Gln Tyr Gly  Gln Lys Ser 
    2285                 2290                 2295             


Leu Asn  Met Ile Ser Ser Asn  Pro Gln Val Gln Tyr  His Asn Asp 
    2300                 2305                 2310             


Lys Tyr  Ile Ser Asn Thr Ser  Gly Glu Asp Glu Lys  Thr His Pro 
    2315                 2320                 2325             


Gly Phe  Gln Gln Met Pro Glu  Asp Lys Glu Asp Glu  Ser Glu Ile 
    2330                 2335                 2340             


Glu Glu  Tyr Ser Cys Ala Val  Thr Pro Gly Gly Asp  Thr Asp Asn 
    2345                 2350                 2355             


Ala Ile  Val Ser Leu Thr Cys  Ala Thr Pro Leu Leu  Asp Glu Thr 
    2360                 2365                 2370             


Ile Ser  Ala Ser Asp Tyr Glu  Thr Ser Leu Leu Asn  Asp Gln Gln 
    2375                 2380                 2385             


Asn Asn  Thr Gly Thr Asp Thr  Asp Ser Asp Asp Asp  Phe Tyr Asp 
    2390                 2395                 2400             


Thr Pro  Leu Phe Glu Asp Asp  Asp His Asp Ser Leu  Leu Leu Asp 
    2405                 2410                 2415             


Gly Asp  Asp Arg Asp Cys Leu  His Pro Glu Asp Tyr  Asp Thr Leu 
    2420                 2425                 2430             


Gln Glu  Glu Asn Asp Glu Thr  Ala Ser Pro Ala Asp  Val Phe Tyr 
    2435                 2440                 2445             


Asp Val  Ser Lys Glu Asn Glu  Asn Ser Met Val Pro  Gln Gly Ala 
    2450                 2455                 2460             


Pro Val  Gly Ser Leu Ser Val  Lys Asn Lys Ala His  Cys Leu Gln 
    2465                 2470                 2475             


Asp Phe  Leu Met Asp Val Glu  Lys Asp Glu Leu Asp  Ser Gly Glu 
    2480                 2485                 2490             


Lys Ile  His Leu Asn Pro Val  Gly Ser Asp Lys Val  Asn Gly Gln 
    2495                 2500                 2505             


Ser Leu  Glu Thr Gly Ser Glu  Arg Glu Cys Thr Asn  Ile Leu Glu 
    2510                 2515                 2520             


Gly Asp  Glu Ser Asp Ser Leu  Thr Asp Tyr Asp Ile  Val Gly Gly 
    2525                 2530                 2535             


Lys Glu  Ser Phe Thr Ala Ser  Leu Lys Phe Asp Asp  Ser Gly Ser 
    2540                 2545                 2550             


Trp Arg  Gly Arg Lys Glu Glu  Tyr Val Thr Gly Gln  Glu Phe His 
    2555                 2560                 2565             


Ser Asp  Thr Asp His Leu Asp  Ser Met Gln Ser Glu  Glu Ser Tyr 
    2570                 2575                 2580             


Gly Asp  Tyr Ile Tyr Asp Ser  Asn Asp Gln Asp Asp  Asp Asp Asp 
    2585                 2590                 2595             


Asp Gly  Ile Asp Glu Glu Gly  Gly Gly Ile Arg Asp  Glu Asn Gly 
    2600                 2605                 2610             


Lys Pro  Arg Cys Gln Asn Val  Ala Glu Asp Met Asp  Ile Gln Leu 
    2615                 2620                 2625             


Cys Ala  Ser Ile Leu Asn Glu  Asn Ser Asp Glu Asn  Glu Asn Ile 
    2630                 2635                 2640             


Asn Thr  Met Ile Leu Leu Asp  Lys Met His Ser Cys  Ser Ser Leu 
    2645                 2650                 2655             


Glu Lys  Gln Gln Arg Val Asn  Val Val Gln Leu Ala  Ser Pro Ser 
    2660                 2665                 2670             


Glu Asn  Asn Leu Val Thr Glu  Lys Ser Asn Leu Pro  Glu Tyr Thr 
    2675                 2680                 2685             


Thr Glu  Ile Ala Gly Lys Ser  Lys Glu Asn Leu Leu  Asn His Glu 
    2690                 2695                 2700             


Met Val  Leu Lys Asp Val Leu  Pro Pro Ile Ile Lys  Asp Thr Glu 
    2705                 2710                 2715             


Ser Glu  Lys Thr Phe Gly Pro  Ala Ser Ile Ser His  Asp Asn Asn 
    2720                 2725                 2730             


Asn Ile  Ser Ser Thr Ser Glu  Leu Gly Thr Asp Leu  Ala Asn Thr 
    2735                 2740                 2745             


Lys Val  Lys Leu Ile Gln Gly  Ser Glu Leu Pro Glu  Leu Thr Asp 
    2750                 2755                 2760             


Ser Val  Lys Gly Lys Asp Glu  Tyr Phe Lys Asn Met  Thr Pro Lys 
    2765                 2770                 2775             


Val Asp  Ser Ser Leu Asp His  Ile Ile Cys Thr Glu  Pro Asp Leu 
    2780                 2785                 2790             


Ile Gly  Lys Pro Ala Glu Glu  Ser His Leu Ser Leu  Ile Ala Ser 
    2795                 2800                 2805             


Val Thr  Asp Lys Asp Pro Gln  Gly Asn Gly Ser Asp  Leu Ile Lys 
    2810                 2815                 2820             


Gly Arg  Asp Gly Lys Ser Asp  Ile Leu Ile Glu Asp  Glu Thr Ser 
    2825                 2830                 2835             


Ile Gln  Lys Met Tyr Leu Gly  Glu Gly Glu Val Leu  Val Glu Gly 
    2840                 2845                 2850             


Leu Val  Glu Glu Glu Asn Arg  His Leu Lys Leu Leu  Pro Gly Lys 
    2855                 2860                 2865             


Asn Thr  Arg Asp Ser Phe Lys  Leu Ile Asn Ser Gln  Phe Pro Phe 
    2870                 2875                 2880             


Pro Gln  Ile Thr Asn Asn Glu  Glu Leu Asn Gln Lys  Gly Ser Leu 
    2885                 2890                 2895             


Lys Lys  Ala Thr Val Thr Leu  Lys Asp Glu Pro Asn  Asn Leu Gln 
    2900                 2905                 2910             


Ile Ile  Val Ser Lys Ser Pro  Val Gln Phe Glu Asn  Leu Glu Glu 
    2915                 2920                 2925             


Ile Phe  Asp Thr Ser Val Ser  Lys Glu Ile Ser Asp  Asp Ile Thr 
    2930                 2935                 2940             


Ser Asp  Ile Thr Ser Trp Glu  Gly Asn Thr His Phe  Glu Glu Ser 
    2945                 2950                 2955             


Phe Thr  Asp Gly Pro Glu Lys  Glu Leu Asp Leu Phe  Thr Tyr Leu 
    2960                 2965                 2970             


Lys His  Cys Ala Lys Asn Ile  Lys Ala Lys Asp Val  Ala Lys Pro 
    2975                 2980                 2985             


Asn Glu  Asp Val Pro Ser His  Val Leu Ile Thr Ala  Pro Pro Met 
    2990                 2995                 3000             


Lys Glu  His Leu Gln Leu Gly  Val Asn Asn Thr Lys  Glu Lys Ser 
    3005                 3010                 3015             


Thr Ser  Thr Gln Lys Asp Ser  Pro Leu Asn Asp Met  Ile Gln Ser 
    3020                 3025                 3030             


Asn Asp  Leu Cys Ser Lys Glu  Ser Ile Ser Gly Gly  Gly Thr Glu 
    3035                 3040                 3045             


Ile Ser  Gln Phe Thr Pro Glu  Ser Ile Glu Ala Thr  Leu Ser Ile 
    3050                 3055                 3060             


Leu Ser  Arg Lys His Val Glu  Asp Val Gly Lys Asn  Asp Phe Leu 
    3065                 3070                 3075             


Gln Ser  Glu Arg Cys Ala Asn  Gly Leu Gly Asn Asp  Asn Ser Ser 
    3080                 3085                 3090             


Asn Thr  Leu Asn Thr Asp Tyr  Ser Phe Leu Glu Ile  Asn Asn Lys 
    3095                 3100                 3105             


Lys Glu  Arg Ile Glu Gln Gln  Leu Pro Lys Glu Gln  Ala Leu Ser 
    3110                 3115                 3120             


Pro Arg  Ser Gln Glu Lys Glu  Val Gln Ile Pro Glu  Leu Ser Gln 
    3125                 3130                 3135             


Val Phe  Val Glu Asp Val Lys  Asp Ile Leu Lys Ser  Arg Leu Lys 
    3140                 3145                 3150             


Glu Gly  His Met Asn Pro Gln  Glu Val Glu Glu Pro  Ser Ala Cys 
    3155                 3160                 3165             


Ala Asp  Thr Lys Ile Leu Ile  Gln Asn Leu Ile Lys  Arg Ile Thr 
    3170                 3175                 3180             


Thr Ser  Gln Leu Val Asn Glu  Ala Ser Thr Val Pro  Ser Asp Ser 
    3185                 3190                 3195             


Gln Met  Ser Asp Ser Ser Gly  Val Ser Pro Met Thr  Asn Ser Ser 
    3200                 3205                 3210             


Glu Leu  Lys Pro Glu Ser Arg  Asp Asp Pro Phe Cys  Ile Gly Asn 
    3215                 3220                 3225             


Leu Lys  Ser Glu Leu Leu Leu  Asn Ile Leu Lys Gln  Asp Gln His 
    3230                 3235                 3240             


Ser Gln  Lys Ile Thr Gly Val  Phe Glu Leu Met Arg  Glu Leu Thr 
    3245                 3250                 3255             


His Met  Glu Tyr Asp Leu Glu  Lys Arg Gly Ile Thr  Ser Lys Val 
    3260                 3265                 3270             


Leu Pro  Leu Gln Leu Glu Asn  Ile Phe Tyr Lys Leu  Leu Ala Asp 
    3275                 3280                 3285             


Gly Tyr  Ser Glu Lys Ile Glu  His Val Gly Asp Phe  Asn Gln Lys 
    3290                 3295                 3300             


Ala Cys  Ser Thr Ser Glu Met  Met Glu Glu Lys Pro  His Ile Leu 
    3305                 3310                 3315             


Gly Asp  Ile Lys Ser Lys Glu  Gly Asn Tyr Tyr Ser  Pro Asn Leu 
    3320                 3325                 3330             


Glu Thr  Val Lys Glu Ile Gly  Leu Glu Ser Ser Thr  Val Trp Ala 
    3335                 3340                 3345             


Ser Thr  Leu Pro Arg Asp Glu  Lys Leu Lys Asp Leu  Cys Asn Asp 
    3350                 3355                 3360             


Phe Pro  Ser His Leu Glu Cys  Thr Ser Gly Ser Lys  Glu Met Ala 
    3365                 3370                 3375             


Ser Gly  Asp Ser Ser Thr Glu  Gln Phe Ser Ser Glu  Leu Gln Gln 
    3380                 3385                 3390             


Cys Leu  Gln His Thr Glu Lys  Met His Glu Tyr Leu  Thr Leu Leu 
    3395                 3400                 3405             


Gln Asp  Met Lys Pro Pro Leu  Asp Asn Gln Glu Ser  Leu Asp Asn 
    3410                 3415                 3420             


Asn Leu  Glu Ala Leu Lys Asn  Gln Leu Arg Gln Leu  Glu Thr Phe 
    3425                 3430                 3435             


Glu Leu  Gly Leu Ala Pro Ile  Ala Val Ile Leu Arg  Lys Asp Met 
    3440                 3445                 3450             


Lys Leu  Ala Glu Glu Phe Leu  Lys Ser Leu Pro Ser  Asp Phe Pro 
    3455                 3460                 3465             


Arg Gly  His Val Glu Glu Leu  Ser Ile Ser His Gln  Ser Leu Lys 
    3470                 3475                 3480             


Thr Ala  Phe Ser Ser Leu Ser  Asn Val Ser Ser Glu  Arg Thr Lys 
    3485                 3490                 3495             


Gln Ile  Met Leu Ala Ile Asp  Ser Glu Met Ser Lys  Leu Ala Val 
    3500                 3505                 3510             


Ser His  Glu Glu Phe Leu His  Lys Leu Lys Ser Phe  Ser Asp Trp 
    3515                 3520                 3525             


Val Ser  Glu Lys Ser Lys Ser  Val Lys Asp Ile Glu  Ile Val Asn 
    3530                 3535                 3540             


Val Gln  Asp Ser Glu Tyr Val  Lys Lys Arg Leu Glu  Phe Leu Lys 
    3545                 3550                 3555             


Asn Val  Leu Lys Asp Leu Gly  His Thr Lys Met Gln  Leu Glu Thr 
    3560                 3565                 3570             


Thr Ala  Phe Asp Val Gln Phe  Phe Ile Ser Glu Tyr  Ala Gln Asp 
    3575                 3580                 3585             


Leu Ser  Pro Asn Gln Ser Lys  Gln Leu Leu Arg Leu  Leu Asn Thr 
    3590                 3595                 3600             


Thr Gln  Lys Cys Phe Leu Asp  Val Gln Glu Ser Val  Thr Thr Gln 
    3605                 3610                 3615             


Val Glu  Arg Leu Glu Thr Gln  Leu His Leu Glu Gln  Asp Leu Asp 
    3620                 3625                 3630             


Asp Gln  Lys Ile Val Ala Glu  Arg Gln Gln Glu Tyr  Lys Glu Lys 
    3635                 3640                 3645             


Leu Gln  Gly Ile Cys Asp Leu  Leu Thr Gln Thr Glu  Asn Arg Leu 
    3650                 3655                 3660             


Ile Gly  His Gln Glu Ala Phe  Met Ile Gly Asp Gly  Thr Val Glu 
    3665                 3670                 3675             


Leu Lys  Lys Tyr Gln Ser Lys  Gln Glu Glu Leu Gln  Lys Asp Met 
    3680                 3685                 3690             


Gln Gly  Ser Ala Gln Ala Leu  Ala Glu Val Val Lys  Asn Thr Glu 
    3695                 3700                 3705             


Asn Phe  Leu Lys Glu Asn Gly  Glu Lys Leu Ser Gln  Glu Asp Lys 
    3710                 3715                 3720             


Ala Leu  Ile Glu Gln Lys Leu  Asn Glu Ala Lys Ile  Lys Cys Glu 
    3725                 3730                 3735             


Gln Leu  Asn Leu Lys Ala Glu  Gln Ser Lys Lys Glu  Leu Asp Lys 
    3740                 3745                 3750             


Val Val  Thr Thr Ala Ile Lys  Glu Glu Thr Glu Lys  Val Ala Ala 
    3755                 3760                 3765             


Val Lys  Gln Leu Glu Glu Ser  Lys Thr Lys Ile Glu  Asn Leu Leu 
    3770                 3775                 3780             


Asp Trp  Leu Ser Asn Val Asp  Lys Asp Ser Glu Arg  Ala Gly Thr 
    3785                 3790                 3795             


Lys His  Lys Gln Val Ile Glu  Gln Asn Gly Thr His  Phe Gln Glu 
    3800                 3805                 3810             


Gly Asp  Gly Lys Ser Ala Ile  Gly Glu Glu Asp Glu  Val Asn Gly 
    3815                 3820                 3825             


Asn Leu  Leu Glu Thr Asp Val  Asp Gly Gln Val Gly  Thr Thr Gln 
    3830                 3835                 3840             


Glu Asn  Leu Asn Gln Gln Tyr  Gln Lys Val Lys Ala  Gln His Glu 
    3845                 3850                 3855             


Lys Ile  Ile Ser Gln His Gln  Ala Val Ile Ile Ala  Thr Gln Ser 
    3860                 3865                 3870             


Ala Gln  Val Leu Leu Glu Lys  Gln Gly Gln Tyr Leu  Ser Pro Glu 
    3875                 3880                 3885             


Glu Lys  Glu Lys Leu Gln Lys  Asn Met Lys Glu Leu  Lys Val His 
    3890                 3895                 3900             


Tyr Glu  Thr Ala Leu Ala Glu  Ser Glu Lys Lys Met  Lys Leu Thr 
    3905                 3910                 3915             


His Ser  Leu Gln Glu Glu Leu  Glu Lys Phe Asp Ala  Asp Tyr Thr 
    3920                 3925                 3930             


Glu Phe  Glu His Trp Leu Gln  Gln Ser Glu Gln Glu  Leu Glu Asn 
    3935                 3940                 3945             


Leu Glu  Ala Gly Ala Asp Asp  Ile Asn Gly Leu Met  Thr Lys Leu 
    3950                 3955                 3960             


Lys Arg  Gln Lys Ser Phe Ser  Glu Asp Val Ile Ser  His Lys Gly 
    3965                 3970                 3975             


Asp Leu  Arg Tyr Ile Thr Ile  Ser Gly Asn Arg Val  Leu Glu Ala 
    3980                 3985                 3990             


Ala Lys  Ser Cys Ser Lys Arg  Asp Gly Gly Lys Val  Asp Thr Ser 
    3995                 4000                 4005             


Ala Thr  His Arg Glu Val Gln  Arg Lys Leu Asp His  Ala Thr Asp 
    4010                 4015                 4020             


Arg Phe  Arg Ser Leu Tyr Ser  Lys Cys Asn Val Leu  Gly Asn Asn 
    4025                 4030                 4035             


Leu Lys  Asp Leu Val Asp Lys  Tyr Gln His Tyr Glu  Asp Ala Ser 
    4040                 4045                 4050             


Cys Gly  Leu Leu Ala Gly Leu  Gln Ala Cys Glu Ala  Thr Ala Ser 
    4055                 4060                 4065             


Lys His  Leu Ser Glu Pro Ile  Ala Val Asp Pro Lys  Asn Leu Gln 
    4070                 4075                 4080             


Arg Gln  Leu Glu Glu Thr Lys  Ala Leu Gln Gly Gln  Ile Ser Ser 
    4085                 4090                 4095             


Gln Gln  Val Ala Val Glu Lys  Leu Lys Lys Thr Ala  Glu Val Leu 
    4100                 4105                 4110             


Leu Asp  Ala Arg Gly Ser Leu  Leu Pro Ala Lys Asn  Asp Ile Gln 
    4115                 4120                 4125             


Lys Thr  Leu Asp Asp Ile Val  Gly Arg Tyr Glu Asp  Leu Ser Lys 
    4130                 4135                 4140             


Ser Val  Asn Glu Arg Asn Glu  Lys Leu Gln Ile Thr  Leu Thr Arg 
    4145                 4150                 4155             


Ser Leu  Ser Val Gln Asp Gly  Leu Asp Glu Met Leu  Asp Trp Met 
    4160                 4165                 4170             


Gly Asn  Val Glu Ser Ser Leu  Lys Glu Gln Gly Gln  Val Pro Leu 
    4175                 4180                 4185             


Asn Ser  Thr Ala Leu Gln Asp  Ile Ile Ser Lys Asn  Ile Met Leu 
    4190                 4195                 4200             


Glu Gln  Asp Ile Ala Gly Arg  Gln Ser Ser Ile Asn  Ala Met Asn 
    4205                 4210                 4215             


Glu Lys  Val Lys Lys Phe Met  Glu Thr Thr Asp Pro  Ser Thr Ala 
    4220                 4225                 4230             


Ser Ser  Leu Gln Ala Lys Met  Lys Asp Leu Ser Ala  Arg Phe Ser 
    4235                 4240                 4245             


Glu Ala  Ser His Lys His Lys  Glu Thr Leu Ala Lys  Met Glu Glu 
    4250                 4255                 4260             


Leu Lys  Thr Lys Val Glu Leu  Phe Glu Asn Leu Ser  Glu Lys Leu 
    4265                 4270                 4275             


Gln Thr  Phe Leu Glu Thr Lys  Thr Gln Ala Leu Thr  Glu Val Asp 
    4280                 4285                 4290             


Val Pro  Gly Lys Asp Val Thr  Glu Leu Ser Gln Tyr  Met Gln Glu 
    4295                 4300                 4305             


Ser Thr  Ser Glu Phe Leu Glu  His Lys Lys His Leu  Glu Val Leu 
    4310                 4315                 4320             


His Ser  Leu Leu Lys Glu Ile  Ser Ser His Gly Leu  Pro Ser Asp 
    4325                 4330                 4335             


Lys Ala  Leu Val Leu Glu Lys  Thr Asn Asn Leu Ser  Lys Lys Phe 
    4340                 4345                 4350             


Lys Glu  Met Glu Asp Thr Ile  Lys Glu Lys Lys Glu  Ala Val Thr 
    4355                 4360                 4365             


Ser Cys  Gln Glu Gln Leu Asp  Ala Phe Gln Val Leu  Val Lys Ser 
    4370                 4375                 4380             


Leu Lys  Ser Trp Ile Lys Glu  Thr Thr Lys Lys Val  Pro Ile Val 
    4385                 4390                 4395             


Gln Pro  Ser Phe Gly Ala Glu  Asp Leu Gly Lys Ser  Leu Glu Asp 
    4400                 4405                 4410             


Thr Lys  Lys Leu Gln Glu Lys  Trp Ser Leu Lys Thr  Pro Glu Ile 
    4415                 4420                 4425             


Gln Lys  Val Asn Asn Ser Gly  Ile Ser Leu Cys Asn  Leu Ile Ser 
    4430                 4435                 4440             


Ala Val  Thr Thr Pro Ala Lys  Ala Ile Ala Ala Val  Lys Ser Gly 
    4445                 4450                 4455             


Gly Ala  Val Leu Asn Gly Glu  Gly Thr Ala Thr Asn  Thr Glu Glu 
    4460                 4465                 4470             


Phe Trp  Ala Asn Lys Gly Leu  Thr Ser Ile Lys Lys  Asp Met Thr 
    4475                 4480                 4485             


Asp Ile  Ser His Gly Tyr Glu  Asp Leu Gly Leu Leu  Leu Lys Asp 
    4490                 4495                 4500             


Lys Ile  Ala Glu Leu Asn Thr  Lys Leu Ser Lys Leu  Gln Lys Ala 
    4505                 4510                 4515             


Gln Glu  Glu Ser Ser Ala Met  Met Gln Trp Leu Gln  Lys Met Asn 
    4520                 4525                 4530             


Lys Thr  Ala Thr Lys Trp Gln  Gln Thr Pro Ala Pro  Thr Asp Thr 
    4535                 4540                 4545             


Glu Ala  Val Lys Thr Gln Val  Glu Gln Asn Lys Ser  Phe Glu Ala 
    4550                 4555                 4560             


Glu Leu  Lys Gln Asn Val Asn  Lys Val Gln Glu Leu  Lys Asp Lys 
    4565                 4570                 4575             


Leu Thr  Glu Leu Leu Glu Glu  Asn Pro Asp Thr Pro  Glu Ala Pro 
    4580                 4585                 4590             


Arg Trp  Lys Gln Met Leu Thr  Glu Ile Asp Ser Lys  Trp Gln Glu 
    4595                 4600                 4605             


Leu Asn  Gln Leu Thr Ile Asp  Arg Gln Gln Lys Leu  Glu Glu Ser 
    4610                 4615                 4620             


Ser Asn  Asn Leu Thr Gln Phe  Gln Thr Val Glu Ala  Gln Leu Lys 
    4625                 4630                 4635             


Gln Trp  Leu Val Glu Lys Glu  Leu Met Val Ser Val  Leu Gly Pro 
    4640                 4645                 4650             


Leu Ser  Ile Asp Pro Asn Met  Leu Asn Thr Gln Arg  Gln Gln Val 
    4655                 4660                 4665             


Gln Ile  Leu Leu Gln Glu Phe  Ala Thr Arg Lys Pro  Gln Tyr Glu 
    4670                 4675                 4680             


Gln Leu  Thr Ala Ala Gly Gln  Gly Ile Leu Ser Arg  Pro Gly Glu 
    4685                 4690                 4695             


Asp Pro  Ser Leu Arg Gly Ile  Val Lys Glu Gln Leu  Ala Ala Val 
    4700                 4705                 4710             


Thr Gln  Lys Trp Asp Ser Leu  Thr Gly Gln Leu Ser  Asp Arg Cys 
    4715                 4720                 4725             


Asp Trp  Ile Asp Gln Ala Ile  Val Lys Ser Thr Gln  Tyr Gln Ser 
    4730                 4735                 4740             


Leu Leu  Arg Ser Leu Ser Asp  Lys Leu Ser Asp Leu  Asp Asn Lys 
    4745                 4750                 4755             


Leu Ser  Ser Ser Leu Ala Val  Ser Thr His Pro Asp  Ala Met Asn 
    4760                 4765                 4770             


Gln Gln  Leu Glu Thr Ala Gln  Lys Met Lys Gln Glu  Ile Gln Gln 
    4775                 4780                 4785             


Glu Lys  Lys Gln Ile Lys Val  Ala Gln Ala Leu Cys  Glu Asp Leu 
    4790                 4795                 4800             


Ser Ala  Leu Val Lys Glu Glu  Tyr Leu Lys Ala Glu  Leu Ser Arg 
    4805                 4810                 4815             


Gln Leu  Glu Gly Ile Leu Lys  Ser Phe Lys Asp Val  Glu Gln Lys 
    4820                 4825                 4830             


Ala Glu  Asn His Val Gln His  Leu Gln Ser Ala Cys  Ala Ser Ser 
    4835                 4840                 4845             


His Gln  Phe Gln Gln Met Ser  Arg Asp Phe Gln Ala  Trp Leu Asp 
    4850                 4855                 4860             


Thr Lys  Lys Glu Glu Gln Asn  Lys Ser His Pro Ile  Ser Ala Lys 
    4865                 4870                 4875             


Leu Asp  Val Leu Glu Ser Leu  Ile Lys Asp His Lys  Asp Phe Ser 
    4880                 4885                 4890             


Lys Thr  Leu Thr Ala Gln Ser  His Met Tyr Glu Lys  Thr Ile Ala 
    4895                 4900                 4905             


Glu Gly  Glu Asn Leu Leu Leu  Lys Thr Gln Gly Ser  Glu Lys Ala 
    4910                 4915                 4920             


Ala Leu  Gln Leu Gln Leu Asn  Thr Ile Lys Thr Asn  Trp Asp Thr 
    4925                 4930                 4935             


Phe Asn  Lys Gln Val Lys Glu  Arg Glu Asn Lys Leu  Lys Glu Ser 
    4940                 4945                 4950             


Leu Glu  Lys Ala Leu Lys Tyr  Lys Glu Gln Val Glu  Thr Leu Trp 
    4955                 4960                 4965             


Pro Trp  Ile Asp Lys Cys Gln  Asn Asn Leu Glu Glu  Ile Lys Phe 
    4970                 4975                 4980             


Cys Leu  Asp Pro Ala Glu Gly  Glu Asn Ser Ile Ala  Lys Leu Lys 
    4985                 4990                 4995             


Ser Leu  Gln Lys Glu Met Asp  Gln His Phe Gly Met  Val Glu Leu 
    5000                 5005                 5010             


Leu Asn  Asn Thr Ala Asn Ser  Leu Leu Ser Val Cys  Glu Ile Asp 
    5015                 5020                 5025             


Lys Glu  Val Val Thr Asp Glu  Asn Lys Ser Leu Ile  Gln Lys Val 
    5030                 5035                 5040             


Asp Met  Val Thr Glu Gln Leu  His Ser Lys Lys Phe  Cys Leu Glu 
    5045                 5050                 5055             


Asn Met  Thr Gln Lys Phe Lys  Glu Phe Gln Glu Val  Ser Lys Glu 
    5060                 5065                 5070             


Ser Lys  Arg Gln Leu Gln Cys  Ala Lys Glu Gln Leu  Asp Ile His 
    5075                 5080                 5085             


Asp Ser  Leu Gly Ser Gln Ala  Tyr Ser Asn Lys Tyr  Leu Thr Met 
    5090                 5095                 5100             


Leu Gln  Thr Gln Gln Lys Ser  Leu Gln Ala Leu Lys  His Gln Val 
    5105                 5110                 5115             


Asp Leu  Ala Lys Arg Leu Ala  Gln Asp Leu Val Val  Glu Ala Ser 
    5120                 5125                 5130             


Asp Ser  Lys Gly Thr Ser Asp  Val Leu Leu Gln Val  Glu Thr Ile 
    5135                 5140                 5145             


Ala Gln  Glu His Ser Thr Leu  Ser Gln Gln Val Asp  Glu Lys Cys 
    5150                 5155                 5160             


Ser Phe  Leu Glu Thr Lys Leu  Gln Gly Ile Gly His  Phe Gln Asn 
    5165                 5170                 5175             


Thr Ile  Arg Glu Met Phe Ser  Gln Phe Ala Glu Phe  Asp Asp Glu 
    5180                 5185                 5190             


Leu Asp  Ser Met Ala Pro Val  Gly Arg Asp Ala Glu  Thr Leu Gln 
    5195                 5200                 5205             


Lys Gln  Lys Glu Thr Ile Lys  Ala Phe Leu Lys Lys  Leu Glu Ala 
    5210                 5215                 5220             


Leu Met  Ala Ser Asn Asp Asn  Ala Asn Lys Thr Cys  Lys Met Met 
    5225                 5230                 5235             


Leu Ala  Thr Glu Glu Thr Ser  Pro Asp Leu Val Gly  Ile Lys Arg 
    5240                 5245                 5250             


Asp Leu  Glu Ala Leu Ser Lys  Gln Cys Asn Lys Leu  Leu Asp Arg 
    5255                 5260                 5265             


Ala Gln  Ala Arg Glu Glu Gln  Val Glu Gly Thr Ile  Lys Arg Leu 
    5270                 5275                 5280             


Glu Glu  Phe Tyr Ser Lys Leu  Lys Glu Phe Ser Ile  Leu Leu Gln 
    5285                 5290                 5295             


Lys Ala  Glu Glu His Glu Glu  Ser Gln Gly Pro Val  Gly Met Glu 
    5300                 5305                 5310             


Thr Glu  Thr Ile Asn Gln Gln  Leu Asn Met Phe Lys  Val Phe Gln 
    5315                 5320                 5325             


Lys Glu  Glu Ile Glu Pro Leu  Gln Gly Lys Gln Gln  Asp Val Asn 
    5330                 5335                 5340             


Trp Leu  Gly Gln Gly Leu Ile  Gln Ser Ala Ala Lys  Ser Thr Ser 
    5345                 5350                 5355             


Thr Gln  Gly Leu Glu His Asp  Leu Asp Asp Val Asn  Ala Arg Trp 
    5360                 5365                 5370             


Lys Thr  Leu Asn Lys Lys Val  Ala Gln Arg Ala Ala  Gln Leu Gln 
    5375                 5380                 5385             


Glu Ala  Leu Leu His Cys Gly  Arg Phe Gln Asp Ala  Leu Glu Ser 
    5390                 5395                 5400             


Leu Leu  Ser Trp Met Val Asp  Thr Glu Glu Leu Val  Ala Asn Gln 
    5405                 5410                 5415             


Lys Pro  Pro Ser Ala Glu Phe  Lys Val Val Lys Ala  Gln Ile Gln 
    5420                 5425                 5430             


Glu Gln  Lys Leu Leu Gln Arg  Leu Leu Asp Asp Arg  Lys Ser Thr 
    5435                 5440                 5445             


Val Glu  Val Ile Lys Arg Glu  Gly Glu Lys Ile Ala  Thr Thr Ala 
    5450                 5455                 5460             


Glu Pro  Ala Asp Lys Val Lys  Ile Leu Lys Gln Leu  Ser Leu Leu 
    5465                 5470                 5475             


Asp Ser  Arg Trp Glu Ala Leu  Leu Asn Lys Ala Glu  Thr Arg Asn 
    5480                 5485                 5490             


Arg Gln  Leu Glu Gly Ile Ser  Val Val Ala Gln Gln  Phe His Glu 
    5495                 5500                 5505             


Thr Leu  Glu Pro Leu Asn Glu  Trp Leu Thr Thr Ile  Glu Lys Arg 
    5510                 5515                 5520             


Leu Val  Asn Cys Glu Pro Ile  Gly Thr Gln Ala Ser  Lys Leu Glu 
    5525                 5530                 5535             


Glu Gln  Ile Ala Gln His Lys  Val Leu Gln Glu Asp  Ile Leu Leu 
    5540                 5545                 5550             


Arg Lys  Gln Asn Val Asp Gln  Ala Leu Leu Asn Gly  Leu Glu Leu 
    5555                 5560                 5565             


Leu Lys  Gln Thr Thr Gly Asp  Glu Val Leu Ile Ile  Gln Asp Lys 
    5570                 5575                 5580             


Leu Glu  Ala Ile Lys Ala Arg  Tyr Lys Asp Ile Thr  Lys Leu Ser 
    5585                 5590                 5595             


Thr Asp  Val Ala Lys Thr Leu  Glu Gln Ala Leu Gln  Leu Ala Arg 
    5600                 5605                 5610             


Arg Leu  His Ser Thr His Glu  Glu Leu Cys Thr Trp  Leu Asp Lys 
    5615                 5620                 5625             


Val Glu  Val Glu Leu Leu Ser  Tyr Glu Thr Gln Val  Leu Lys Gly 
    5630                 5635                 5640             


Glu Glu  Ala Ser Gln Ala Gln  Met Arg Pro Lys Glu  Leu Lys Lys 
    5645                 5650                 5655             


Glu Ala  Lys Asn Asn Lys Ala  Leu Leu Asp Ser Leu  Asn Glu Val 
    5660                 5665                 5670             


Ser Ser  Ala Leu Leu Glu Leu  Val Pro Trp Arg Ala  Arg Glu Gly 
    5675                 5680                 5685             


Leu Glu  Lys Met Val Ala Glu  Asp Asn Glu Arg Tyr  Arg Leu Val 
    5690                 5695                 5700             


Ser Asp  Thr Ile Thr Gln Lys  Val Glu Glu Ile Asp  Ala Ala Ile 
    5705                 5710                 5715             


Leu Arg  Ser Gln Gln Phe Asp  Gln Ala Ala Asp Ala  Glu Leu Ser 
    5720                 5725                 5730             


Trp Ile  Thr Glu Thr Glu Lys  Lys Leu Met Ser Leu  Gly Asp Ile 
    5735                 5740                 5745             


Arg Leu  Glu Gln Asp Gln Thr  Ser Ala Gln Leu Gln  Val Gln Lys 
    5750                 5755                 5760             


Thr Phe  Thr Met Glu Ile Leu  Arg His Lys Asp Ile  Ile Asp Asp 
    5765                 5770                 5775             


Leu Val  Lys Ser Gly His Lys  Ile Met Thr Ala Cys  Ser Glu Glu 
    5780                 5785                 5790             


Glu Lys  Gln Ser Met Lys Lys  Lys Leu Asp Lys Val  Leu Lys Asn 
    5795                 5800                 5805             


Tyr Asp  Thr Ile Cys Gln Ile  Asn Ser Glu Arg Tyr  Leu Gln Leu 
    5810                 5815                 5820             


Glu Arg  Ala Gln Ser Leu Val  Asn Gln Phe Trp Glu  Thr Tyr Glu 
    5825                 5830                 5835             


Glu Leu  Trp Pro Trp Leu Thr  Glu Thr Gln Ser Ile  Ile Ser Gln 
    5840                 5845                 5850             


Leu Pro  Ala Pro Ala Leu Glu  Tyr Glu Thr Leu Arg  Gln Gln Gln 
    5855                 5860                 5865             


Glu Glu  His Arg Gln Leu Arg  Glu Leu Ile Ala Glu  His Lys Pro 
    5870                 5875                 5880             


His Ile  Asp Lys Met Asn Lys  Thr Gly Pro Gln Leu  Leu Glu Leu 
    5885                 5890                 5895             


Ser Pro  Gly Glu Gly Phe Ser  Ile Gln Glu Lys Tyr  Val Ala Ala 
    5900                 5905                 5910             


Asp Thr  Leu Tyr Ser Gln Ile  Lys Glu Asp Val Lys  Lys Arg Ala 
    5915                 5920                 5925             


Val Ala  Leu Asp Glu Ala Ile  Ser Gln Ser Thr Gln  Phe His Asp 
    5930                 5935                 5940             


Lys Ile  Asp Gln Ile Leu Glu  Ser Leu Glu Arg Ile  Val Glu Arg 
    5945                 5950                 5955             


Leu Arg  Gln Pro Pro Ser Ile  Ser Ala Glu Val Glu  Lys Ile Lys 
    5960                 5965                 5970             


Glu Gln  Ile Ser Glu Asn Lys  Asn Val Ser Val Asp  Met Glu Lys 
    5975                 5980                 5985             


Leu Gln  Pro Leu Tyr Glu Thr  Leu Lys Gln Arg Gly  Glu Glu Met 
    5990                 5995                 6000             


Ile Ala  Arg Ser Gly Gly Thr  Asp Lys Asp Ile Ser  Ala Lys Ala 
    6005                 6010                 6015             


Val Gln  Asp Lys Leu Asp Gln  Met Val Phe Ile Trp  Glu Asn Ile 
    6020                 6025                 6030             


His Thr  Leu Val Glu Glu Arg  Glu Ala Lys Leu Leu  Asp Val Met 
    6035                 6040                 6045             


Glu Leu  Ala Glu Lys Phe Trp  Cys Asp His Met Ser  Leu Ile Val 
    6050                 6055                 6060             


Thr Ile  Lys Asp Thr Gln Asp  Phe Ile Arg Asp Leu  Glu Asp Pro 
    6065                 6070                 6075             


Gly Ile  Asp Pro Ser Val Val  Lys Gln Gln Gln Glu  Ala Ala Glu 
    6080                 6085                 6090             


Thr Ile  Arg Glu Glu Ile Asp  Gly Leu Gln Glu Glu  Leu Asp Ile 
    6095                 6100                 6105             


Val Ile  Asn Leu Gly Ser Glu  Leu Ile Ala Ala Cys  Gly Glu Pro 
    6110                 6115                 6120             


Asp Lys  Pro Ile Val Lys Lys  Ser Ile Asp Glu Leu  Asn Ser Ala 
    6125                 6130                 6135             


Trp Asp  Ser Leu Asn Lys Ala  Trp Lys Asp Arg Ile  Asp Lys Leu 
    6140                 6145                 6150             


Glu Glu  Ala Met Gln Ala Ala  Val Gln Tyr Gln Asp  Gly Leu Gln 
    6155                 6160                 6165             


Ala Val  Phe Asp Trp Val Asp  Ile Ala Gly Gly Lys  Leu Ala Ser 
    6170                 6175                 6180             


Met Ser  Pro Ile Gly Thr Asp  Leu Glu Thr Val Lys  Gln Gln Ile 
    6185                 6190                 6195             


Glu Glu  Leu Lys Gln Phe Lys  Ser Glu Ala Tyr Gln  Gln Gln Ile 
    6200                 6205                 6210             


Glu Met  Glu Arg Leu Asn His  Gln Ala Glu Leu Leu  Leu Lys Lys 
    6215                 6220                 6225             


Val Thr  Glu Glu Ser Asp Lys  His Thr Val Gln Asp  Pro Leu Met 
    6230                 6235                 6240             


Glu Leu  Lys Leu Ile Trp Asp  Ser Leu Glu Glu Arg  Ile Ile Asn 
    6245                 6250                 6255             


Arg Gln  His Lys Leu Glu Gly  Ala Leu Leu Ala Leu  Gly Gln Phe 
    6260                 6265                 6270             


Gln His  Ala Leu Asp Glu Leu  Leu Ala Trp Leu Thr  His Thr Glu 
    6275                 6280                 6285             


Gly Leu  Leu Ser Glu Gln Lys  Pro Val Gly Gly Asp  Pro Lys Ala 
    6290                 6295                 6300             


Ile Glu  Ile Glu Leu Ala Lys  His His Val Leu Gln  Asn Asp Val 
    6305                 6310                 6315             


Leu Ala  His Gln Ser Thr Val  Glu Ala Val Asn Lys  Ala Gly Asn 
    6320                 6325                 6330             


Asp Leu  Ile Glu Ser Ser Ala  Gly Glu Glu Ala Ser  Asn Leu Gln 
    6335                 6340                 6345             


Asn Lys  Leu Glu Val Leu Asn  Gln Arg Trp Gln Asn  Val Leu Glu 
    6350                 6355                 6360             


Lys Thr  Glu Gln Arg Lys Gln  Gln Leu Asp Gly Ala  Leu Arg Gln 
    6365                 6370                 6375             


Ala Lys  Gly Phe His Gly Glu  Ile Glu Asp Leu Gln  Gln Trp Leu 
    6380                 6385                 6390             


Thr Asp  Thr Glu Arg His Leu  Leu Ala Ser Lys Pro  Leu Gly Gly 
    6395                 6400                 6405             


Leu Pro  Glu Thr Ala Lys Glu  Gln Leu Asn Val His  Met Glu Val 
    6410                 6415                 6420             


Cys Ala  Ala Phe Glu Ala Lys  Glu Glu Thr Tyr Lys  Ser Leu Met 
    6425                 6430                 6435             


Gln Lys  Gly Gln Gln Met Leu  Ala Arg Cys Pro Lys  Ser Ala Glu 
    6440                 6445                 6450             


Thr Asn  Ile Asp Gln Asp Ile  Asn Asn Leu Lys Glu  Lys Trp Glu 
    6455                 6460                 6465             


Ser Val  Glu Thr Lys Leu Asn  Glu Arg Lys Thr Lys  Leu Glu Glu 
    6470                 6475                 6480             


Ala Leu  Asn Leu Ala Met Glu  Phe His Asn Ser Leu  Gln Asp Phe 
    6485                 6490                 6495             


Ile Asn  Trp Leu Thr Gln Ala  Glu Gln Thr Leu Asn  Val Ala Ser 
    6500                 6505                 6510             


Arg Pro  Ser Leu Ile Leu Asp  Thr Val Leu Phe Gln  Ile Asp Glu 
    6515                 6520                 6525             


His Lys  Val Phe Ala Asn Glu  Val Asn Ser His Arg  Glu Gln Ile 
    6530                 6535                 6540             


Ile Glu  Leu Asp Lys Thr Gly  Thr His Leu Lys Tyr  Phe Ser Gln 
    6545                 6550                 6555             


Lys Gln  Asp Val Val Leu Ile  Lys Asn Leu Leu Ile  Ser Val Gln 
    6560                 6565                 6570             


Ser Arg  Trp Glu Lys Val Val  Gln Arg Leu Val Glu  Arg Gly Arg 
    6575                 6580                 6585             


Ser Leu  Asp Asp Ala Arg Lys  Arg Ala Lys Gln Phe  His Glu Ala 
    6590                 6595                 6600             


Trp Ser  Lys Leu Met Glu Trp  Leu Glu Glu Ser Glu  Lys Ser Leu 
    6605                 6610                 6615             


Asp Ser  Glu Leu Glu Ile Ala  Asn Asp Pro Asp Lys  Ile Lys Thr 
    6620                 6625                 6630             


Gln Leu  Ala Gln His Lys Glu  Phe Gln Lys Ser Leu  Gly Ala Lys 
    6635                 6640                 6645             


His Ser  Val Tyr Asp Thr Thr  Asn Arg Thr Gly Arg  Ser Leu Lys 
    6650                 6655                 6660             


Glu Lys  Thr Ser Leu Ala Asp  Asp Asn Leu Lys Leu  Asp Asp Met 
    6665                 6670                 6675             


Leu Ser  Glu Leu Arg Asp Lys  Trp Asp Thr Ile Cys  Gly Lys Ser 
    6680                 6685                 6690             


Val Glu  Arg Gln Asn Lys Leu  Glu Glu Ala Leu Leu  Phe Ser Gly 
    6695                 6700                 6705             


Gln Phe  Thr Asp Ala Leu Gln  Ala Leu Ile Asp Trp  Leu Tyr Arg 
    6710                 6715                 6720             


Val Glu  Pro Gln Leu Ala Glu  Asp Gln Pro Val His  Gly Asp Ile 
    6725                 6730                 6735             


Asp Leu  Val Met Asn Leu Ile  Asp Asn His Lys Ala  Phe Gln Lys 
    6740                 6745                 6750             


Glu Leu  Gly Lys Arg Thr Ser  Ser Val Gln Ala Leu  Lys Arg Ser 
    6755                 6760                 6765             


Ala Arg  Glu Leu Ile Glu Gly  Ser Arg Asp Asp Ser  Ser Trp Val 
    6770                 6775                 6780             


Lys Val  Gln Met Gln Glu Leu  Ser Thr Arg Trp Glu  Thr Val Cys 
    6785                 6790                 6795             


Ala Leu  Ser Ile Ser Lys Gln  Thr Arg Leu Glu Ala  Ala Leu Arg 
    6800                 6805                 6810             


Gln Ala  Glu Glu Phe His Ser  Val Val His Ala Leu  Leu Glu Trp 
    6815                 6820                 6825             


Leu Ala  Glu Ala Glu Gln Thr  Leu Arg Phe His Gly  Val Leu Pro 
    6830                 6835                 6840             


Asp Asp  Glu Asp Ala Leu Arg  Thr Leu Ile Asp Gln  His Lys Glu 
    6845                 6850                 6855             


Phe Met  Lys Lys Leu Glu Glu  Lys Arg Ala Glu Leu  Asn Lys Ala 
    6860                 6865                 6870             


Thr Thr  Met Gly Asp Thr Val  Leu Ala Ile Cys His  Pro Asp Ser 
    6875                 6880                 6885             


Ile Thr  Thr Ile Lys His Trp  Ile Thr Ile Ile Arg  Ala Arg Phe 
    6890                 6895                 6900             


Glu Glu  Val Leu Ala Trp Ala  Lys Gln His Gln Gln  Arg Leu Ala 
    6905                 6910                 6915             


Ser Ala  Leu Ala Gly Leu Ile  Ala Lys Gln Glu Leu  Leu Glu Ala 
    6920                 6925                 6930             


Leu Leu  Ala Trp Leu Gln Trp  Ala Glu Thr Thr Leu  Thr Asp Lys 
    6935                 6940                 6945             


Asp Lys  Glu Val Ile Pro Gln  Glu Ile Glu Glu Val  Lys Ala Leu 
    6950                 6955                 6960             


Ile Ala  Glu His Gln Thr Phe  Met Glu Glu Met Thr  Arg Lys Gln 
    6965                 6970                 6975             


Pro Asp  Val Asp Lys Val Thr  Lys Thr Tyr Lys Arg  Arg Ala Ala 
    6980                 6985                 6990             


Asp Pro  Ser Ser Leu Gln Ser  His Ile Pro Val Leu  Asp Lys Gly 
    6995                 7000                 7005             


Arg Ala  Gly Arg Lys Arg Phe  Pro Ala Ser Ser Leu  Tyr Pro Ser 
    7010                 7015                 7020             


Gly Ser  Gln Thr Gln Ile Glu  Thr Lys Asn Pro Arg  Val Asn Leu 
    7025                 7030                 7035             


Leu Val  Ser Lys Trp Gln Gln  Val Trp Leu Leu Ala  Leu Glu Arg 
    7040                 7045                 7050             


Arg Arg  Lys Leu Asn Asp Ala  Leu Asp Arg Leu Glu  Glu Leu Arg 
    7055                 7060                 7065             


Glu Phe  Ala Asn Phe Asp Phe  Asp Ile Trp Arg Lys  Lys Tyr Met 
    7070                 7075                 7080             


Arg Trp  Met Asn His Lys Lys  Ser Arg Val Met Asp  Phe Phe Arg 
    7085                 7090                 7095             


Arg Ile  Asp Lys Asp Gln Asp  Gly Lys Ile Thr Arg  Gln Glu Phe 
    7100                 7105                 7110             


Ile Asp  Gly Ile Leu Ser Ser  Lys Phe Pro Thr Ser  Arg Leu Glu 
    7115                 7120                 7125             


Met Ser  Ala Val Ala Asp Ile  Phe Asp Arg Asp Gly  Asp Gly Tyr 
    7130                 7135                 7140             


Ile Asp  Tyr Tyr Glu Phe Val  Ala Ala Leu His Pro  Asn Lys Asp 
    7145                 7150                 7155             


Ala Tyr  Lys Pro Ile Thr Asp  Ala Asp Lys Ile Glu  Asp Glu Val 
    7160                 7165                 7170             


Thr Arg  Gln Val Ala Lys Cys  Lys Cys Ala Lys Arg  Phe Gln Val 
    7175                 7180                 7185             


Glu Gln  Ile Gly Asp Asn Lys  Tyr Arg Phe Phe Leu  Gly Asn Gln 
    7190                 7195                 7200             


Phe Gly  Asp Ser Gln Gln Leu  Arg Leu Val Arg Ile  Leu Arg Ser 
    7205                 7210                 7215             


Thr Val  Met Val Arg Val Gly  Gly Gly Trp Met Ala  Leu Asp Glu 
    7220                 7225                 7230             


Phe Leu  Val Lys Asn Asp Pro  Cys Arg Val His His  His Gly Ser 
    7235                 7240                 7245             


Lys Met  Leu Arg Ser Glu Ser  Asn Ser Ser Ile Thr  Thr Thr Gln 
    7250                 7255                 7260             


Pro Thr  Ile Ala Lys Gly Arg  Thr Asn Met Glu Leu  Arg Glu Lys 
    7265                 7270                 7275             


Phe Ile  Leu Ala Asp Gly Ala  Ser Gln Gly Met Ala  Ala Phe Arg 
    7280                 7285                 7290             


Pro Arg  Gly Arg Arg Ser Arg  Pro Ser Ser Arg Gly  Ala Ser Pro 
    7295                 7300                 7305             


Asn Arg  Ser Thr Ser Val Ser  Ser Gln Ala Ala Gln  Ala Ala Ser 
    7310                 7315                 7320             


Pro Gln  Val Pro Ala Thr Thr  Thr Pro Lys Gly Thr  Pro Ile Gln 
    7325                 7330                 7335             


Gly Ser  Lys Leu Arg Leu Pro  Gly Tyr Leu Ser Gly  Lys Gly Phe 
    7340                 7345                 7350             


His Ser  Gly Glu Asp Ser Gly  Leu Ile Thr Thr Ala  Ala Ala Arg 
    7355                 7360                 7365             


Val Arg  Thr Gln Phe Ala Asp  Ser Lys Lys Thr Pro  Ser Arg Pro 
    7370                 7375                 7380             


Gly Ser  Arg Ala Gly Ser Lys  Ala Gly Ser Arg Ala  Ser Ser Arg 
    7385                 7390                 7395             


Arg Gly  Ser Asp Ala Ser Asp  Phe Asp Ile Ser Glu  Ile Gln Ser 
    7400                 7405                 7410             


Val Cys  Ser Asp Val Glu Thr  Val Pro Gln Thr His  Arg Pro Thr 
    7415                 7420                 7425             


Pro Arg  Ala Gly Ser Arg Pro  Ser Thr Ala Lys Pro  Ser Lys Ile 
    7430                 7435                 7440             


Pro Thr  Pro Gln Arg Lys Ser  Pro Ala Ser Lys Leu  Asp Lys Ser 
    7445                 7450                 7455             


Ser Lys  Arg 
    7460     


<210>  4452
<211>  5375
<212>  PRT
<213>  Homo Sapiens

<400>  4452

Met Ala Gly Tyr Leu Ser Pro Ala Ala Tyr Leu Tyr Val Glu Glu Gln 
1               5                   10                  15      


Glu Tyr Leu Gln Ala Tyr Glu Asp Val Leu Glu Arg Tyr Lys Asp Glu 
            20                  25                  30          


Arg Asp Lys Val Gln Lys Lys Thr Phe Thr Lys Trp Ile Asn Gln His 
        35                  40                  45              


Leu Met Lys Val Arg Lys His Val Asn Asp Leu Tyr Glu Asp Leu Arg 
    50                  55                  60                  


Asp Gly His Asn Leu Ile Ser Leu Leu Glu Val Leu Ser Gly Asp Thr 
65                  70                  75                  80  


Leu Pro Arg Glu Lys Gly Arg Met Arg Phe His Arg Leu Gln Asn Val 
                85                  90                  95      


Gln Ile Ala Leu Asp Tyr Leu Lys Arg Arg Gln Val Lys Leu Val Asn 
            100                 105                 110         


Ile Arg Asn Asp Asp Ile Thr Asp Gly Asn Pro Lys Leu Thr Leu Gly 
        115                 120                 125             


Leu Ile Trp Thr Ile Ile Leu His Phe Gln Ile Ser Asp Ile His Val 
    130                 135                 140                 


Thr Gly Glu Ser Glu Asp Met Ser Ala Lys Glu Arg Leu Leu Leu Trp 
145                 150                 155                 160 


Thr Gln Gln Ala Thr Glu Gly Tyr Ala Gly Ile Arg Cys Glu Asn Phe 
                165                 170                 175     


Thr Thr Cys Trp Arg Asp Gly Lys Leu Phe Asn Ala Ile Ile His Lys 
            180                 185                 190         


Tyr Arg Pro Asp Leu Ile Asp Met Asn Thr Val Ala Val Gln Ser Asn 
        195                 200                 205             


Leu Ala Asn Leu Glu His Ala Phe Tyr Val Ala Glu Lys Ile Gly Val 
    210                 215                 220                 


Ile Arg Leu Leu Asp Pro Glu Asp Val Asp Val Ser Ser Pro Asp Glu 
225                 230                 235                 240 


Lys Ser Val Ile Thr Tyr Val Ser Ser Leu Tyr Asp Ala Phe Pro Lys 
                245                 250                 255     


Val Pro Glu Gly Gly Glu Gly Ile Gly Ala Asn Asp Val Glu Val Lys 
            260                 265                 270         


Trp Ile Glu Tyr Gln Asn Met Val Asn Tyr Leu Ile Gln Trp Ile Arg 
        275                 280                 285             


His His Val Thr Thr Met Ser Glu Arg Thr Phe Pro Asn Asn Pro Val 
    290                 295                 300                 


Glu Leu Lys Ala Leu Tyr Asn Gln Tyr Leu Gln Phe Lys Glu Thr Glu 
305                 310                 315                 320 


Ile Pro Pro Lys Glu Thr Glu Lys Ser Lys Ile Lys Arg Leu Tyr Lys 
                325                 330                 335     


Leu Leu Glu Ile Trp Ile Glu Phe Gly Arg Ile Lys Leu Leu Gln Gly 
            340                 345                 350         


Tyr His Pro Asn Asp Ile Glu Lys Glu Trp Gly Lys Leu Ile Ile Ala 
        355                 360                 365             


Met Leu Glu Arg Glu Lys Ala Leu Arg Pro Glu Val Glu Arg Leu Glu 
    370                 375                 380                 


Met Leu Gln Gln Ile Ala Asn Arg Val Gln Arg Asp Ser Val Ile Cys 
385                 390                 395                 400 


Glu Asp Lys Leu Ile Leu Ala Gly Asn Ala Leu Gln Ser Asp Ser Lys 
                405                 410                 415     


Arg Leu Glu Ser Gly Val Gln Phe Gln Asn Glu Ala Glu Ile Ala Gly 
            420                 425                 430         


Tyr Ile Leu Glu Cys Glu Asn Leu Leu Arg Gln His Val Ile Asp Val 
        435                 440                 445             


Gln Ile Leu Ile Asp Gly Lys Tyr Tyr Gln Ala Asp Gln Leu Val Gln 
    450                 455                 460                 


Arg Val Ala Lys Leu Arg Asp Glu Ile Met Ala Leu Arg Asn Glu Cys 
465                 470                 475                 480 


Ser Ser Val Tyr Ser Lys Gly Arg Ile Leu Thr Thr Glu Gln Thr Lys 
                485                 490                 495     


Leu Met Ile Ser Gly Ile Thr Gln Ser Leu Asn Ser Gly Phe Ala Gln 
            500                 505                 510         


Thr Leu His Pro Ser Leu Thr Ser Gly Leu Thr Gln Ser Leu Thr Pro 
        515                 520                 525             


Ser Leu Thr Ser Ser Ser Met Thr Ser Gly Leu Ser Ser Gly Met Thr 
    530                 535                 540                 


Ser Arg Leu Thr Pro Ser Val Thr Pro Ala Tyr Thr Pro Gly Phe Pro 
545                 550                 555                 560 


Ser Gly Leu Val Pro Asn Phe Ser Ser Gly Val Glu Pro Asn Ser Leu 
                565                 570                 575     


Gln Thr Leu Lys Leu Met Gln Ile Arg Lys Pro Leu Leu Lys Ser Ser 
            580                 585                 590         


Leu Leu Asp Gln Asn Leu Thr Glu Glu Glu Ile Asn Met Lys Phe Val 
        595                 600                 605             


Gln Asp Leu Leu Asn Trp Val Asp Glu Met Gln Val Gln Leu Asp Arg 
    610                 615                 620                 


Thr Glu Trp Gly Ser Asp Leu Pro Ser Val Glu Ser His Leu Glu Asn 
625                 630                 635                 640 


His Lys Asn Val His Arg Ala Ile Glu Glu Phe Glu Ser Ser Leu Lys 
                645                 650                 655     


Glu Ala Lys Ile Ser Glu Ile Gln Met Thr Ala Pro Leu Lys Leu Thr 
            660                 665                 670         


Tyr Ala Glu Lys Leu His Arg Leu Glu Ser Gln Tyr Ala Lys Leu Leu 
        675                 680                 685             


Asn Thr Ser Arg Asn Gln Glu Arg His Leu Asp Thr Leu His Asn Phe 
    690                 695                 700                 


Val Ser Arg Ala Thr Asn Glu Leu Ile Trp Leu Asn Glu Lys Glu Glu 
705                 710                 715                 720 


Glu Glu Val Ala Tyr Asp Trp Ser Glu Arg Asn Thr Asn Ile Ala Arg 
                725                 730                 735     


Lys Lys Asp Tyr His Ala Glu Leu Met Arg Glu Leu Asp Gln Lys Glu 
            740                 745                 750         


Glu Asn Ile Lys Ser Val Gln Glu Ile Ala Glu Gln Leu Leu Leu Glu 
        755                 760                 765             


Asn His Pro Ala Arg Leu Thr Ile Glu Ala Tyr Arg Ala Ala Met Gln 
    770                 775                 780                 


Thr Gln Trp Ser Trp Ile Leu Gln Leu Cys Gln Cys Val Glu Gln His 
785                 790                 795                 800 


Ile Lys Glu Asn Thr Ala Tyr Phe Glu Phe Phe Asn Asp Ala Lys Glu 
                805                 810                 815     


Ala Thr Asp Tyr Leu Arg Asn Leu Lys Asp Ala Ile Gln Arg Lys Tyr 
            820                 825                 830         


Ser Cys Asp Arg Ser Ser Ser Ile His Lys Leu Glu Asp Leu Val Gln 
        835                 840                 845             


Glu Ser Met Glu Glu Lys Glu Glu Leu Leu Gln Tyr Lys Ser Thr Ile 
    850                 855                 860                 


Ala Asn Leu Met Gly Lys Ala Lys Thr Ile Ile Gln Leu Lys Pro Arg 
865                 870                 875                 880 


Asn Ser Asp Cys Pro Leu Lys Thr Ser Ile Pro Ile Lys Ala Ile Cys 
                885                 890                 895     


Asp Tyr Arg Gln Ile Glu Ile Thr Ile Tyr Lys Asp Asp Glu Cys Val 
            900                 905                 910         


Leu Ala Asn Asn Ser His Arg Ala Lys Trp Lys Val Ile Ser Pro Thr 
        915                 920                 925             


Gly Asn Glu Ala Met Val Pro Ser Val Cys Phe Thr Val Pro Pro Pro 
    930                 935                 940                 


Asn Lys Glu Ala Val Asp Leu Ala Asn Arg Ile Glu Gln Gln Tyr Gln 
945                 950                 955                 960 


Asn Val Leu Thr Leu Trp His Glu Ser His Ile Asn Met Lys Ser Val 
                965                 970                 975     


Val Ser Trp His Tyr Leu Ile Asn Glu Ile Asp Arg Ile Arg Ala Ser 
            980                 985                 990         


Asn Val Ala Ser Ile Lys Thr Met  Leu Pro Gly Glu His  Gln Gln Val 
        995                 1000                 1005             


Leu Ser  Asn Leu Gln Ser Arg  Phe Glu Asp Phe Leu  Glu Asp Ser 
    1010                 1015                 1020             


Gln Glu  Ser Gln Val Phe Ser  Gly Ser Asp Ile Thr  Gln Leu Glu 
    1025                 1030                 1035             


Lys Glu  Val Asn Val Cys Lys  Gln Tyr Tyr Gln Glu  Leu Leu Lys 
    1040                 1045                 1050             


Ser Ala  Glu Arg Glu Glu Gln  Glu Glu Ser Val Tyr  Asn Leu Tyr 
    1055                 1060                 1065             


Ile Ser  Glu Val Arg Asn Ile  Arg Leu Arg Leu Glu  Asn Cys Glu 
    1070                 1075                 1080             


Asp Arg  Leu Ile Arg Gln Ile  Arg Thr Pro Leu Glu  Arg Asp Asp 
    1085                 1090                 1095             


Leu His  Glu Ser Val Phe Arg  Ile Thr Glu Gln Glu  Lys Leu Lys 
    1100                 1105                 1110             


Lys Glu  Leu Glu Arg Leu Lys  Asp Asp Leu Gly Thr  Ile Thr Asn 
    1115                 1120                 1125             


Lys Cys  Glu Glu Phe Phe Ser  Gln Ala Ala Ala Ser  Ser Ser Val 
    1130                 1135                 1140             


Pro Thr  Leu Arg Ser Glu Leu  Asn Val Val Leu Gln  Asn Met Asn 
    1145                 1150                 1155             


Gln Val  Tyr Ser Met Ser Ser  Thr Tyr Ile Asp Lys  Leu Lys Thr 
    1160                 1165                 1170             


Val Asn  Leu Val Leu Lys Asn  Thr Gln Ala Ala Glu  Ala Leu Val 
    1175                 1180                 1185             


Lys Leu  Tyr Glu Thr Lys Leu  Cys Glu Glu Glu Ala  Val Ile Ala 
    1190                 1195                 1200             


Asp Lys  Asn Asn Ile Glu Asn  Leu Ile Ser Thr Leu  Lys Gln Trp 
    1205                 1210                 1215             


Arg Ser  Glu Val Asp Glu Lys  Arg Gln Val Phe His  Ala Leu Glu 
    1220                 1225                 1230             


Asp Glu  Leu Gln Lys Ala Lys  Ala Ile Ser Asp Glu  Met Phe Lys 
    1235                 1240                 1245             


Thr Tyr  Lys Glu Arg Asp Leu  Asp Phe Asp Trp His  Lys Glu Lys 
    1250                 1255                 1260             


Ala Asp  Gln Leu Val Glu Arg  Trp Gln Asn Val His  Val Gln Ile 
    1265                 1270                 1275             


Asp Asn  Arg Leu Arg Asp Leu  Glu Gly Ile Gly Lys  Ser Leu Lys 
    1280                 1285                 1290             


Tyr Tyr  Arg Asp Thr Tyr His  Pro Leu Asp Asp Trp  Ile Gln Gln 
    1295                 1300                 1305             


Val Glu  Thr Thr Gln Arg Lys  Ile Gln Glu Asn Gln  Pro Glu Asn 
    1310                 1315                 1320             


Ser Lys  Thr Leu Ala Thr Gln  Leu Asn Gln Gln Lys  Met Leu Val 
    1325                 1330                 1335             


Ser Glu  Ile Glu Met Lys Gln  Ser Lys Met Asp Glu  Cys Gln Lys 
    1340                 1345                 1350             


Tyr Ala  Glu Gln Tyr Ser Ala  Thr Val Lys Asp Tyr  Glu Leu Gln 
    1355                 1360                 1365             


Thr Met  Thr Tyr Arg Ala Met  Val Asp Ser Gln Gln  Lys Ser Pro 
    1370                 1375                 1380             


Val Lys  Arg Arg Arg Met Gln  Ser Ser Ala Asp Leu  Ile Ile Gln 
    1385                 1390                 1395             


Glu Phe  Met Asp Leu Arg Thr  Arg Tyr Thr Ala Leu  Val Thr Leu 
    1400                 1405                 1410             


Met Thr  Gln Tyr Ile Lys Phe  Ala Gly Asp Ser Leu  Lys Arg Leu 
    1415                 1420                 1425             


Glu Glu  Glu Glu Lys Ser Leu  Glu Glu Glu Lys Lys  Glu His Val 
    1430                 1435                 1440             


Glu Lys  Ala Lys Glu Leu Gln  Lys Trp Val Ser Asn  Ile Ser Lys 
    1445                 1450                 1455             


Thr Leu  Lys Asp Ala Glu Lys  Ala Gly Lys Pro Pro  Phe Ser Lys 
    1460                 1465                 1470             


Gln Lys  Ile Ser Ser Glu Glu  Ile Ser Thr Lys Lys  Glu Gln Leu 
    1475                 1480                 1485             


Ser Glu  Ala Leu Gln Thr Ile  Gln Leu Phe Leu Ala  Lys His Gly 
    1490                 1495                 1500             


Asp Lys  Met Thr Asp Glu Glu  Arg Asn Glu Leu Glu  Lys Gln Val 
    1505                 1510                 1515             


Lys Thr  Leu Gln Glu Ser Tyr  Asn Leu Leu Phe Ser  Glu Ser Leu 
    1520                 1525                 1530             


Lys Gln  Leu Gln Glu Ser Gln  Thr Ser Gly Asp Val  Lys Val Glu 
    1535                 1540                 1545             


Glu Lys  Ile Val Ala Glu Arg  Gln Gln Glu Tyr Lys  Glu Lys Leu 
    1550                 1555                 1560             


Gln Gly  Ile Cys Asp Leu Leu  Thr Gln Thr Glu Asn  Arg Leu Ile 
    1565                 1570                 1575             


Gly His  Gln Glu Ala Phe Met  Ile Gly Asp Gly Thr  Val Glu Leu 
    1580                 1585                 1590             


Lys Lys  Tyr Gln Ser Lys Gln  Glu Glu Leu Gln Lys  Asp Met Gln 
    1595                 1600                 1605             


Gly Ser  Ala Gln Ala Leu Ala  Glu Val Val Lys Asn  Thr Glu Asn 
    1610                 1615                 1620             


Phe Leu  Lys Glu Asn Gly Glu  Lys Leu Ser Gln Glu  Asp Lys Ala 
    1625                 1630                 1635             


Leu Ile  Glu Gln Lys Leu Asn  Glu Ala Lys Ile Lys  Cys Glu Gln 
    1640                 1645                 1650             


Leu Asn  Leu Lys Ala Glu Gln  Ser Lys Lys Glu Leu  Asp Lys Val 
    1655                 1660                 1665             


Val Thr  Thr Ala Ile Lys Glu  Glu Thr Glu Lys Val  Ala Ala Val 
    1670                 1675                 1680             


Lys Gln  Leu Glu Glu Ser Lys  Thr Lys Ile Glu Asn  Leu Leu Asp 
    1685                 1690                 1695             


Trp Leu  Ser Asn Val Asp Lys  Asp Ser Glu Arg Ala  Gly Thr Lys 
    1700                 1705                 1710             


His Lys  Gln Val Ile Glu Gln  Asn Gly Thr His Phe  Gln Glu Gly 
    1715                 1720                 1725             


Asp Gly  Lys Ser Ala Ile Gly  Glu Glu Asp Glu Val  Asn Gly Asn 
    1730                 1735                 1740             


Leu Leu  Glu Thr Asp Val Asp  Gly Gln Val Gly Thr  Thr Gln Glu 
    1745                 1750                 1755             


Asn Leu  Asn Gln Gln Tyr Gln  Lys Val Lys Ala Gln  His Glu Lys 
    1760                 1765                 1770             


Ile Ile  Ser Gln His Gln Ala  Val Ile Ile Ala Thr  Gln Ser Ala 
    1775                 1780                 1785             


Gln Val  Leu Leu Glu Lys Gln  Gly Gln Tyr Leu Ser  Pro Glu Glu 
    1790                 1795                 1800             


Lys Glu  Lys Leu Gln Lys Asn  Met Lys Glu Leu Lys  Val His Tyr 
    1805                 1810                 1815             


Glu Thr  Ala Leu Ala Glu Ser  Glu Lys Lys Met Lys  Leu Thr His 
    1820                 1825                 1830             


Ser Leu  Gln Glu Glu Leu Glu  Lys Phe Asp Ala Asp  Tyr Thr Glu 
    1835                 1840                 1845             


Phe Glu  His Trp Leu Gln Gln  Ser Glu Gln Glu Leu  Glu Asn Leu 
    1850                 1855                 1860             


Glu Ala  Gly Ala Asp Asp Ile  Asn Gly Leu Met Thr  Lys Leu Lys 
    1865                 1870                 1875             


Arg Gln  Lys Ser Phe Ser Glu  Asp Val Ile Ser His  Lys Gly Asp 
    1880                 1885                 1890             


Leu Arg  Tyr Ile Thr Ile Ser  Gly Asn Arg Val Leu  Glu Ala Ala 
    1895                 1900                 1905             


Lys Ser  Cys Ser Lys Arg Asp  Gly Gly Lys Val Asp  Thr Ser Ala 
    1910                 1915                 1920             


Thr His  Arg Glu Val Gln Arg  Lys Leu Asp His Ala  Thr Asp Arg 
    1925                 1930                 1935             


Phe Arg  Ser Leu Tyr Ser Lys  Cys Asn Val Leu Gly  Asn Asn Leu 
    1940                 1945                 1950             


Lys Asp  Leu Val Asp Lys Tyr  Gln His Tyr Glu Asp  Ala Ser Cys 
    1955                 1960                 1965             


Gly Leu  Leu Ala Gly Leu Gln  Ala Cys Glu Ala Thr  Ala Ser Lys 
    1970                 1975                 1980             


His Leu  Ser Glu Pro Ile Ala  Val Asp Pro Lys Asn  Leu Gln Arg 
    1985                 1990                 1995             


Gln Leu  Glu Glu Thr Lys Ala  Leu Gln Gly Gln Ile  Ser Ser Gln 
    2000                 2005                 2010             


Gln Val  Ala Val Glu Lys Leu  Lys Lys Thr Ala Glu  Val Leu Leu 
    2015                 2020                 2025             


Asp Ala  Arg Gly Ser Leu Leu  Pro Ala Lys Asn Asp  Ile Gln Lys 
    2030                 2035                 2040             


Thr Leu  Asp Asp Ile Val Gly  Arg Tyr Glu Asp Leu  Ser Lys Ser 
    2045                 2050                 2055             


Val Asn  Glu Arg Asn Glu Lys  Leu Gln Ile Thr Leu  Thr Arg Ser 
    2060                 2065                 2070             


Leu Ser  Val Gln Asp Gly Leu  Asp Glu Met Leu Asp  Trp Met Gly 
    2075                 2080                 2085             


Asn Val  Glu Ser Ser Leu Lys  Glu Gln Gly Gln Val  Pro Leu Asn 
    2090                 2095                 2100             


Ser Thr  Ala Leu Gln Asp Ile  Ile Ser Lys Asn Ile  Met Leu Glu 
    2105                 2110                 2115             


Gln Asp  Ile Ala Gly Arg Gln  Ser Ser Ile Asn Ala  Met Asn Glu 
    2120                 2125                 2130             


Lys Val  Lys Lys Phe Met Glu  Thr Thr Asp Pro Ser  Thr Ala Ser 
    2135                 2140                 2145             


Ser Leu  Gln Ala Lys Met Lys  Asp Leu Ser Ala Arg  Phe Ser Glu 
    2150                 2155                 2160             


Ala Ser  His Lys His Lys Glu  Thr Leu Ala Lys Met  Glu Glu Leu 
    2165                 2170                 2175             


Lys Thr  Lys Val Glu Leu Phe  Glu Asn Leu Ser Glu  Lys Leu Gln 
    2180                 2185                 2190             


Thr Phe  Leu Glu Thr Lys Thr  Gln Ala Leu Thr Glu  Val Asp Val 
    2195                 2200                 2205             


Pro Gly  Lys Asp Val Thr Glu  Leu Ser Gln Tyr Met  Gln Glu Ser 
    2210                 2215                 2220             


Thr Ser  Glu Phe Leu Glu His  Lys Lys His Leu Glu  Val Leu His 
    2225                 2230                 2235             


Ser Leu  Leu Lys Glu Ile Ser  Ser His Gly Leu Pro  Ser Asp Lys 
    2240                 2245                 2250             


Ala Leu  Val Leu Glu Lys Thr  Asn Asn Leu Ser Lys  Lys Phe Lys 
    2255                 2260                 2265             


Glu Met  Glu Asp Thr Ile Lys  Glu Lys Lys Glu Ala  Val Thr Ser 
    2270                 2275                 2280             


Cys Gln  Glu Gln Leu Asp Ala  Phe Gln Val Leu Val  Lys Ser Leu 
    2285                 2290                 2295             


Lys Ser  Trp Ile Lys Glu Thr  Thr Lys Lys Val Pro  Ile Val Gln 
    2300                 2305                 2310             


Pro Ser  Phe Gly Ala Glu Asp  Leu Gly Lys Ser Leu  Glu Asp Thr 
    2315                 2320                 2325             


Lys Lys  Leu Gln Glu Lys Trp  Ser Leu Lys Thr Pro  Glu Ile Gln 
    2330                 2335                 2340             


Lys Val  Asn Asn Ser Gly Ile  Ser Leu Cys Asn Leu  Ile Ser Ala 
    2345                 2350                 2355             


Val Thr  Thr Pro Ala Lys Ala  Ile Ala Ala Val Lys  Ser Gly Gly 
    2360                 2365                 2370             


Ala Val  Leu Asn Gly Glu Gly  Thr Ala Thr Asn Thr  Glu Glu Phe 
    2375                 2380                 2385             


Trp Ala  Asn Lys Gly Leu Thr  Ser Ile Lys Lys Asp  Met Thr Asp 
    2390                 2395                 2400             


Ile Ser  His Gly Tyr Glu Asp  Leu Gly Leu Leu Leu  Lys Asp Lys 
    2405                 2410                 2415             


Ile Ala  Glu Leu Asn Thr Lys  Leu Ser Lys Leu Gln  Lys Ala Gln 
    2420                 2425                 2430             


Glu Glu  Ser Ser Ala Met Met  Gln Trp Leu Gln Lys  Met Asn Lys 
    2435                 2440                 2445             


Thr Ala  Thr Lys Trp Gln Gln  Thr Pro Ala Pro Thr  Asp Thr Glu 
    2450                 2455                 2460             


Ala Val  Lys Thr Gln Val Glu  Gln Asn Lys Ser Phe  Glu Ala Glu 
    2465                 2470                 2475             


Leu Lys  Gln Asn Val Asn Lys  Val Gln Glu Leu Lys  Asp Lys Leu 
    2480                 2485                 2490             


Thr Glu  Leu Leu Glu Glu Asn  Pro Asp Thr Pro Glu  Ala Pro Arg 
    2495                 2500                 2505             


Trp Lys  Gln Met Leu Thr Glu  Ile Asp Ser Lys Trp  Gln Glu Leu 
    2510                 2515                 2520             


Asn Gln  Leu Thr Ile Asp Arg  Gln Gln Lys Leu Glu  Glu Ser Ser 
    2525                 2530                 2535             


Asn Asn  Leu Thr Gln Phe Gln  Thr Val Glu Ala Gln  Leu Lys Gln 
    2540                 2545                 2550             


Trp Leu  Val Glu Lys Glu Leu  Met Val Ser Val Leu  Gly Pro Leu 
    2555                 2560                 2565             


Ser Ile  Asp Pro Asn Met Leu  Asn Thr Gln Arg Gln  Gln Val Gln 
    2570                 2575                 2580             


Ile Leu  Leu Gln Glu Phe Ala  Thr Arg Lys Pro Gln  Tyr Glu Gln 
    2585                 2590                 2595             


Leu Thr  Ala Ala Gly Gln Gly  Ile Leu Ser Arg Pro  Gly Glu Asp 
    2600                 2605                 2610             


Pro Ser  Leu Arg Gly Ile Val  Lys Glu Gln Leu Ala  Ala Val Thr 
    2615                 2620                 2625             


Gln Lys  Trp Asp Ser Leu Thr  Gly Gln Leu Ser Asp  Arg Cys Asp 
    2630                 2635                 2640             


Trp Ile  Asp Gln Ala Ile Val  Lys Ser Thr Gln Tyr  Gln Ser Leu 
    2645                 2650                 2655             


Leu Arg  Ser Leu Ser Asp Lys  Leu Ser Asp Leu Asp  Asn Lys Leu 
    2660                 2665                 2670             


Ser Ser  Ser Leu Ala Val Ser  Thr His Pro Asp Ala  Met Asn Gln 
    2675                 2680                 2685             


Gln Leu  Glu Thr Ala Gln Lys  Met Lys Gln Glu Ile  Gln Gln Glu 
    2690                 2695                 2700             


Lys Lys  Gln Ile Lys Val Ala  Gln Ala Leu Cys Glu  Asp Leu Ser 
    2705                 2710                 2715             


Ala Leu  Val Lys Glu Glu Tyr  Leu Lys Ala Glu Leu  Ser Arg Gln 
    2720                 2725                 2730             


Leu Glu  Gly Ile Leu Lys Ser  Phe Lys Asp Val Glu  Gln Lys Ala 
    2735                 2740                 2745             


Glu Asn  His Val Gln His Leu  Gln Ser Ala Cys Ala  Ser Ser His 
    2750                 2755                 2760             


Gln Phe  Gln Gln Met Ser Arg  Asp Phe Gln Ala Trp  Leu Asp Thr 
    2765                 2770                 2775             


Lys Lys  Glu Glu Gln Asn Lys  Ser His Pro Ile Ser  Ala Lys Leu 
    2780                 2785                 2790             


Asp Val  Leu Glu Ser Leu Ile  Lys Asp His Lys Asp  Phe Ser Lys 
    2795                 2800                 2805             


Thr Leu  Thr Ala Gln Ser His  Met Tyr Glu Lys Thr  Ile Ala Glu 
    2810                 2815                 2820             


Gly Glu  Asn Leu Leu Leu Lys  Thr Gln Gly Ser Glu  Lys Ala Ala 
    2825                 2830                 2835             


Leu Gln  Leu Gln Leu Asn Thr  Ile Lys Thr Asn Trp  Asp Thr Phe 
    2840                 2845                 2850             


Asn Lys  Gln Val Lys Glu Arg  Glu Asn Lys Leu Lys  Glu Ser Leu 
    2855                 2860                 2865             


Glu Lys  Ala Leu Lys Tyr Lys  Glu Gln Val Glu Thr  Leu Trp Pro 
    2870                 2875                 2880             


Trp Ile  Asp Lys Cys Gln Asn  Asn Leu Glu Glu Ile  Lys Phe Cys 
    2885                 2890                 2895             


Leu Asp  Pro Ala Glu Gly Glu  Asn Ser Ile Ala Lys  Leu Lys Ser 
    2900                 2905                 2910             


Leu Gln  Lys Glu Met Asp Gln  His Phe Gly Met Val  Glu Leu Leu 
    2915                 2920                 2925             


Asn Asn  Thr Ala Asn Ser Leu  Leu Ser Val Cys Glu  Ile Asp Lys 
    2930                 2935                 2940             


Glu Val  Val Thr Asp Glu Asn  Lys Ser Leu Ile Gln  Lys Val Asp 
    2945                 2950                 2955             


Met Val  Thr Glu Gln Leu His  Ser Lys Lys Phe Cys  Leu Glu Asn 
    2960                 2965                 2970             


Met Thr  Gln Lys Phe Lys Glu  Phe Gln Glu Val Ser  Lys Glu Ser 
    2975                 2980                 2985             


Lys Arg  Gln Leu Gln Cys Ala  Lys Glu Gln Leu Asp  Ile His Asp 
    2990                 2995                 3000             


Ser Leu  Gly Ser Gln Ala Tyr  Ser Asn Lys Tyr Leu  Thr Met Leu 
    3005                 3010                 3015             


Gln Thr  Gln Gln Lys Ser Leu  Gln Ala Leu Lys His  Gln Val Asp 
    3020                 3025                 3030             


Leu Ala  Lys Arg Leu Ala Gln  Asp Leu Val Val Glu  Ala Ser Asp 
    3035                 3040                 3045             


Ser Lys  Gly Thr Ser Asp Val  Leu Leu Gln Val Glu  Thr Ile Ala 
    3050                 3055                 3060             


Gln Glu  His Ser Thr Leu Ser  Gln Gln Val Asp Glu  Lys Cys Ser 
    3065                 3070                 3075             


Phe Leu  Glu Thr Lys Leu Gln  Gly Ile Gly His Phe  Gln Asn Thr 
    3080                 3085                 3090             


Ile Arg  Glu Met Phe Ser Gln  Phe Ala Glu Phe Asp  Asp Glu Leu 
    3095                 3100                 3105             


Asp Ser  Met Ala Pro Val Gly  Arg Asp Ala Glu Thr  Leu Gln Lys 
    3110                 3115                 3120             


Gln Lys  Glu Thr Ile Lys Ala  Phe Leu Lys Lys Leu  Glu Ala Leu 
    3125                 3130                 3135             


Met Ala  Ser Asn Asp Asn Ala  Asn Lys Thr Cys Lys  Met Met Leu 
    3140                 3145                 3150             


Ala Thr  Glu Glu Thr Ser Pro  Asp Leu Val Gly Ile  Lys Arg Asp 
    3155                 3160                 3165             


Leu Glu  Ala Leu Ser Lys Gln  Cys Asn Lys Leu Leu  Asp Arg Ala 
    3170                 3175                 3180             


Gln Ala  Arg Glu Glu Gln Val  Glu Gly Thr Ile Lys  Arg Leu Glu 
    3185                 3190                 3195             


Glu Phe  Tyr Ser Lys Leu Lys  Glu Phe Ser Ile Leu  Leu Gln Lys 
    3200                 3205                 3210             


Ala Glu  Glu His Glu Glu Ser  Gln Gly Pro Val Gly  Met Glu Thr 
    3215                 3220                 3225             


Glu Thr  Ile Asn Gln Gln Leu  Asn Met Phe Lys Val  Phe Gln Lys 
    3230                 3235                 3240             


Glu Glu  Ile Glu Pro Leu Gln  Gly Lys Gln Gln Asp  Val Asn Trp 
    3245                 3250                 3255             


Leu Gly  Gln Gly Leu Ile Gln  Ser Ala Ala Lys Ser  Thr Ser Thr 
    3260                 3265                 3270             


Gln Gly  Leu Glu His Asp Leu  Asp Asp Val Asn Ala  Arg Trp Lys 
    3275                 3280                 3285             


Thr Leu  Asn Lys Lys Val Ala  Gln Arg Ala Ala Gln  Leu Gln Glu 
    3290                 3295                 3300             


Ala Leu  Leu His Cys Gly Arg  Phe Gln Asp Ala Leu  Glu Ser Leu 
    3305                 3310                 3315             


Leu Ser  Trp Met Val Asp Thr  Glu Glu Leu Val Ala  Asn Gln Lys 
    3320                 3325                 3330             


Pro Pro  Ser Ala Glu Phe Lys  Val Val Lys Ala Gln  Ile Gln Glu 
    3335                 3340                 3345             


Gln Lys  Leu Leu Gln Arg Leu  Leu Asp Asp Arg Lys  Ser Thr Val 
    3350                 3355                 3360             


Glu Val  Ile Lys Arg Glu Gly  Glu Lys Ile Ala Thr  Thr Ala Glu 
    3365                 3370                 3375             


Pro Ala  Asp Lys Val Lys Ile  Leu Lys Gln Leu Ser  Leu Leu Asp 
    3380                 3385                 3390             


Ser Arg  Trp Glu Ala Leu Leu  Asn Lys Ala Glu Thr  Arg Asn Arg 
    3395                 3400                 3405             


Gln Leu  Glu Gly Ile Ser Val  Val Ala Gln Gln Phe  His Glu Thr 
    3410                 3415                 3420             


Leu Glu  Pro Leu Asn Glu Trp  Leu Thr Thr Ile Glu  Lys Arg Leu 
    3425                 3430                 3435             


Val Asn  Cys Glu Pro Ile Gly  Thr Gln Ala Ser Lys  Leu Glu Glu 
    3440                 3445                 3450             


Gln Ile  Ala Gln His Lys Val  Leu Gln Glu Asp Ile  Leu Leu Arg 
    3455                 3460                 3465             


Lys Gln  Asn Val Asp Gln Ala  Leu Leu Asn Gly Leu  Glu Leu Leu 
    3470                 3475                 3480             


Lys Gln  Thr Thr Gly Asp Glu  Val Leu Ile Ile Gln  Asp Lys Leu 
    3485                 3490                 3495             


Glu Ala  Ile Lys Ala Arg Tyr  Lys Asp Ile Thr Lys  Leu Ser Thr 
    3500                 3505                 3510             


Asp Val  Ala Lys Thr Leu Glu  Gln Ala Leu Gln Leu  Ala Arg Arg 
    3515                 3520                 3525             


Leu His  Ser Thr His Glu Glu  Leu Cys Thr Trp Leu  Asp Lys Val 
    3530                 3535                 3540             


Glu Val  Glu Leu Leu Ser Tyr  Glu Thr Gln Val Leu  Lys Gly Glu 
    3545                 3550                 3555             


Glu Ala  Ser Gln Ala Gln Met  Arg Pro Lys Glu Leu  Lys Lys Glu 
    3560                 3565                 3570             


Ala Lys  Asn Asn Lys Ala Leu  Leu Asp Ser Leu Asn  Glu Val Ser 
    3575                 3580                 3585             


Ser Ala  Leu Leu Glu Leu Val  Pro Trp Arg Ala Arg  Glu Gly Leu 
    3590                 3595                 3600             


Glu Lys  Met Val Ala Glu Asp  Asn Glu Arg Tyr Arg  Leu Val Ser 
    3605                 3610                 3615             


Asp Thr  Ile Thr Gln Lys Val  Glu Glu Ile Asp Ala  Ala Ile Leu 
    3620                 3625                 3630             


Arg Ser  Gln Gln Phe Asp Gln  Ala Ala Asp Ala Glu  Leu Ser Trp 
    3635                 3640                 3645             


Ile Thr  Glu Thr Glu Lys Lys  Leu Met Ser Leu Gly  Asp Ile Arg 
    3650                 3655                 3660             


Leu Glu  Gln Asp Gln Thr Ser  Ala Gln Leu Gln Val  Gln Lys Thr 
    3665                 3670                 3675             


Phe Thr  Met Glu Ile Leu Arg  His Lys Asp Ile Ile  Asp Asp Leu 
    3680                 3685                 3690             


Val Lys  Ser Gly His Lys Ile  Met Thr Ala Cys Ser  Glu Glu Glu 
    3695                 3700                 3705             


Lys Gln  Ser Met Lys Lys Lys  Leu Asp Lys Val Leu  Lys Asn Tyr 
    3710                 3715                 3720             


Asp Thr  Ile Cys Gln Ile Asn  Ser Glu Arg Tyr Leu  Gln Leu Glu 
    3725                 3730                 3735             


Arg Ala  Gln Ser Leu Val Asn  Gln Phe Trp Glu Thr  Tyr Glu Glu 
    3740                 3745                 3750             


Leu Trp  Pro Trp Leu Thr Glu  Thr Gln Ser Ile Ile  Ser Gln Leu 
    3755                 3760                 3765             


Pro Ala  Pro Ala Leu Glu Tyr  Glu Thr Leu Arg Gln  Gln Gln Glu 
    3770                 3775                 3780             


Glu His  Arg Gln Leu Arg Glu  Leu Ile Ala Glu His  Lys Pro His 
    3785                 3790                 3795             


Ile Asp  Lys Met Asn Lys Thr  Gly Pro Gln Leu Leu  Glu Leu Ser 
    3800                 3805                 3810             


Pro Gly  Glu Gly Phe Ser Ile  Gln Glu Lys Tyr Val  Ala Ala Asp 
    3815                 3820                 3825             


Thr Leu  Tyr Ser Gln Ile Lys  Glu Asp Val Lys Lys  Arg Ala Val 
    3830                 3835                 3840             


Ala Leu  Asp Glu Ala Ile Ser  Gln Ser Thr Gln Phe  His Asp Lys 
    3845                 3850                 3855             


Ile Asp  Gln Ile Leu Glu Ser  Leu Glu Arg Ile Val  Glu Arg Leu 
    3860                 3865                 3870             


Arg Gln  Pro Pro Ser Ile Ser  Ala Glu Val Glu Lys  Ile Lys Glu 
    3875                 3880                 3885             


Gln Ile  Ser Glu Asn Lys Asn  Val Ser Val Asp Met  Glu Lys Leu 
    3890                 3895                 3900             


Gln Pro  Leu Tyr Glu Thr Leu  Lys Gln Arg Gly Glu  Glu Met Ile 
    3905                 3910                 3915             


Ala Arg  Ser Gly Gly Thr Asp  Lys Asp Ile Ser Ala  Lys Ala Val 
    3920                 3925                 3930             


Gln Asp  Lys Leu Asp Gln Met  Val Phe Ile Trp Glu  Asn Ile His 
    3935                 3940                 3945             


Thr Leu  Val Glu Glu Arg Glu  Ala Lys Leu Leu Asp  Val Met Glu 
    3950                 3955                 3960             


Leu Ala  Glu Lys Phe Trp Cys  Asp His Met Ser Leu  Ile Val Thr 
    3965                 3970                 3975             


Ile Lys  Asp Thr Gln Asp Phe  Ile Arg Asp Leu Glu  Asp Pro Gly 
    3980                 3985                 3990             


Ile Asp  Pro Ser Val Val Lys  Gln Gln Gln Glu Ala  Ala Glu Thr 
    3995                 4000                 4005             


Ile Arg  Glu Glu Ile Asp Gly  Leu Gln Glu Glu Leu  Asp Ile Val 
    4010                 4015                 4020             


Ile Asn  Leu Gly Ser Glu Leu  Ile Ala Ala Cys Gly  Glu Pro Asp 
    4025                 4030                 4035             


Lys Pro  Ile Val Lys Lys Ser  Ile Asp Glu Leu Asn  Ser Ala Trp 
    4040                 4045                 4050             


Asp Ser  Leu Asn Lys Ala Trp  Lys Asp Arg Ile Asp  Lys Leu Glu 
    4055                 4060                 4065             


Glu Ala  Met Gln Ala Ala Val  Gln Tyr Gln Asp Gly  Leu Gln Ala 
    4070                 4075                 4080             


Val Phe  Asp Trp Val Asp Ile  Ala Gly Gly Lys Leu  Ala Ser Met 
    4085                 4090                 4095             


Ser Pro  Ile Gly Thr Asp Leu  Glu Thr Val Lys Gln  Gln Ile Glu 
    4100                 4105                 4110             


Glu Leu  Lys Gln Phe Lys Ser  Glu Ala Tyr Gln Gln  Gln Ile Glu 
    4115                 4120                 4125             


Met Glu  Arg Leu Asn His Gln  Ala Glu Leu Leu Leu  Lys Lys Val 
    4130                 4135                 4140             


Thr Glu  Glu Ser Asp Lys His  Thr Val Gln Asp Pro  Leu Met Glu 
    4145                 4150                 4155             


Leu Lys  Leu Ile Trp Asp Ser  Leu Glu Glu Arg Ile  Ile Asn Arg 
    4160                 4165                 4170             


Gln His  Lys Leu Glu Gly Ala  Leu Leu Ala Leu Gly  Gln Phe Gln 
    4175                 4180                 4185             


His Ala  Leu Asp Glu Leu Leu  Ala Trp Leu Thr His  Thr Glu Gly 
    4190                 4195                 4200             


Leu Leu  Ser Glu Gln Lys Pro  Val Gly Gly Asp Pro  Lys Ala Ile 
    4205                 4210                 4215             


Glu Ile  Glu Leu Ala Lys His  His Val Leu Gln Asn  Asp Val Leu 
    4220                 4225                 4230             


Ala His  Gln Ser Thr Val Glu  Ala Val Asn Lys Ala  Gly Asn Asp 
    4235                 4240                 4245             


Leu Ile  Glu Ser Ser Ala Gly  Glu Glu Ala Ser Asn  Leu Gln Asn 
    4250                 4255                 4260             


Lys Leu  Glu Val Leu Asn Gln  Arg Trp Gln Asn Val  Leu Glu Lys 
    4265                 4270                 4275             


Thr Glu  Gln Arg Lys Gln Gln  Leu Asp Gly Ala Leu  Arg Gln Ala 
    4280                 4285                 4290             


Lys Gly  Phe His Gly Glu Ile  Glu Asp Leu Gln Gln  Trp Leu Thr 
    4295                 4300                 4305             


Asp Thr  Glu Arg His Leu Leu  Ala Ser Lys Pro Leu  Gly Gly Leu 
    4310                 4315                 4320             


Pro Glu  Thr Ala Lys Glu Gln  Leu Asn Val His Met  Glu Val Cys 
    4325                 4330                 4335             


Ala Ala  Phe Glu Ala Lys Glu  Glu Thr Tyr Lys Ser  Leu Met Gln 
    4340                 4345                 4350             


Lys Gly  Gln Gln Met Leu Ala  Arg Cys Pro Lys Ser  Ala Glu Thr 
    4355                 4360                 4365             


Asn Ile  Asp Gln Asp Ile Asn  Asn Leu Lys Glu Lys  Trp Glu Ser 
    4370                 4375                 4380             


Val Glu  Thr Lys Leu Asn Glu  Arg Lys Thr Lys Leu  Glu Glu Ala 
    4385                 4390                 4395             


Leu Asn  Leu Ala Met Glu Phe  His Asn Ser Leu Gln  Asp Phe Ile 
    4400                 4405                 4410             


Asn Trp  Leu Thr Gln Ala Glu  Gln Thr Leu Asn Val  Ala Ser Arg 
    4415                 4420                 4425             


Pro Ser  Leu Ile Leu Asp Thr  Val Leu Phe Gln Ile  Asp Glu His 
    4430                 4435                 4440             


Lys Val  Phe Ala Asn Glu Val  Asn Ser His Arg Glu  Gln Ile Ile 
    4445                 4450                 4455             


Glu Leu  Asp Lys Thr Gly Thr  His Leu Lys Tyr Phe  Ser Gln Lys 
    4460                 4465                 4470             


Gln Asp  Val Val Leu Ile Lys  Asn Leu Leu Ile Ser  Val Gln Ser 
    4475                 4480                 4485             


Arg Trp  Glu Lys Val Val Gln  Arg Leu Val Glu Arg  Gly Arg Ser 
    4490                 4495                 4500             


Leu Asp  Asp Ala Arg Lys Arg  Ala Lys Gln Phe His  Glu Ala Trp 
    4505                 4510                 4515             


Ser Lys  Leu Met Glu Trp Leu  Glu Glu Ser Glu Lys  Ser Leu Asp 
    4520                 4525                 4530             


Ser Glu  Leu Glu Ile Ala Asn  Asp Pro Asp Lys Ile  Lys Thr Gln 
    4535                 4540                 4545             


Leu Ala  Gln His Lys Glu Phe  Gln Lys Ser Leu Gly  Ala Lys His 
    4550                 4555                 4560             


Ser Val  Tyr Asp Thr Thr Asn  Arg Thr Gly Arg Ser  Leu Lys Glu 
    4565                 4570                 4575             


Lys Thr  Ser Leu Ala Asp Asp  Asn Leu Lys Leu Asp  Asp Met Leu 
    4580                 4585                 4590             


Ser Glu  Leu Arg Asp Lys Trp  Asp Thr Ile Cys Gly  Lys Ser Val 
    4595                 4600                 4605             


Glu Arg  Gln Asn Lys Leu Glu  Glu Ala Leu Leu Phe  Ser Gly Gln 
    4610                 4615                 4620             


Phe Thr  Asp Ala Leu Gln Ala  Leu Ile Asp Trp Leu  Tyr Arg Val 
    4625                 4630                 4635             


Glu Pro  Gln Leu Ala Glu Asp  Gln Pro Val His Gly  Asp Ile Asp 
    4640                 4645                 4650             


Leu Val  Met Asn Leu Ile Asp  Asn His Lys Ala Phe  Gln Lys Glu 
    4655                 4660                 4665             


Leu Gly  Lys Arg Thr Ser Ser  Val Gln Ala Leu Lys  Arg Ser Ala 
    4670                 4675                 4680             


Arg Glu  Leu Ile Glu Gly Ser  Arg Asp Asp Ser Ser  Trp Val Lys 
    4685                 4690                 4695             


Val Gln  Met Gln Glu Leu Ser  Thr Arg Trp Glu Thr  Val Cys Ala 
    4700                 4705                 4710             


Leu Ser  Ile Ser Lys Gln Thr  Arg Leu Glu Ala Ala  Leu Arg Gln 
    4715                 4720                 4725             


Ala Glu  Glu Phe His Ser Val  Val His Ala Leu Leu  Glu Trp Leu 
    4730                 4735                 4740             


Ala Glu  Ala Glu Gln Thr Leu  Arg Phe His Gly Val  Leu Pro Asp 
    4745                 4750                 4755             


Asp Glu  Asp Ala Leu Arg Thr  Leu Ile Asp Gln His  Lys Glu Phe 
    4760                 4765                 4770             


Met Lys  Lys Leu Glu Glu Lys  Arg Ala Glu Leu Asn  Lys Ala Thr 
    4775                 4780                 4785             


Thr Met  Gly Asp Thr Val Leu  Ala Ile Cys His Pro  Asp Ser Ile 
    4790                 4795                 4800             


Thr Thr  Ile Lys His Trp Ile  Thr Ile Ile Arg Ala  Arg Phe Glu 
    4805                 4810                 4815             


Glu Val  Leu Ala Trp Ala Lys  Gln His Gln Gln Arg  Leu Ala Ser 
    4820                 4825                 4830             


Ala Leu  Ala Gly Leu Ile Ala  Lys Gln Glu Leu Leu  Glu Ala Leu 
    4835                 4840                 4845             


Leu Ala  Trp Leu Gln Trp Ala  Glu Thr Thr Leu Thr  Asp Lys Asp 
    4850                 4855                 4860             


Lys Glu  Val Ile Pro Gln Glu  Ile Glu Glu Val Lys  Ala Leu Ile 
    4865                 4870                 4875             


Ala Glu  His Gln Thr Phe Met  Glu Glu Met Thr Arg  Lys Gln Pro 
    4880                 4885                 4890             


Asp Val  Asp Lys Val Thr Lys  Thr Tyr Lys Arg Arg  Ala Ala Asp 
    4895                 4900                 4905             


Pro Ser  Ser Leu Gln Ser His  Ile Pro Val Leu Asp  Lys Gly Arg 
    4910                 4915                 4920             


Ala Gly  Arg Lys Arg Phe Pro  Ala Ser Ser Leu Tyr  Pro Ser Gly 
    4925                 4930                 4935             


Ser Gln  Thr Gln Ile Glu Thr  Lys Asn Pro Arg Val  Asn Leu Leu 
    4940                 4945                 4950             


Val Ser  Lys Trp Gln Gln Val  Trp Leu Leu Ala Leu  Glu Arg Arg 
    4955                 4960                 4965             


Arg Lys  Leu Asn Asp Ala Leu  Asp Arg Leu Glu Glu  Leu Arg Glu 
    4970                 4975                 4980             


Phe Ala  Asn Phe Asp Phe Asp  Ile Trp Arg Lys Lys  Tyr Met Arg 
    4985                 4990                 4995             


Trp Met  Asn His Lys Lys Ser  Arg Val Met Asp Phe  Phe Arg Arg 
    5000                 5005                 5010             


Ile Asp  Lys Asp Gln Asp Gly  Lys Ile Thr Arg Gln  Glu Phe Ile 
    5015                 5020                 5025             


Asp Gly  Ile Leu Ser Ser Lys  Phe Pro Thr Ser Arg  Leu Glu Met 
    5030                 5035                 5040             


Ser Ala  Val Ala Asp Ile Phe  Asp Arg Asp Gly Asp  Gly Tyr Ile 
    5045                 5050                 5055             


Asp Tyr  Tyr Glu Phe Val Ala  Ala Leu His Pro Asn  Lys Asp Ala 
    5060                 5065                 5070             


Tyr Lys  Pro Ile Thr Asp Ala  Asp Lys Ile Glu Asp  Glu Val Thr 
    5075                 5080                 5085             


Arg Gln  Val Ala Lys Cys Lys  Cys Ala Lys Arg Phe  Gln Val Glu 
    5090                 5095                 5100             


Gln Ile  Gly Asp Asn Lys Tyr  Arg Phe Phe Leu Gly  Asn Gln Phe 
    5105                 5110                 5115             


Gly Asp  Ser Gln Gln Leu Arg  Leu Val Arg Ile Leu  Arg Ser Thr 
    5120                 5125                 5130             


Val Met  Val Arg Val Gly Gly  Gly Trp Met Ala Leu  Asp Glu Phe 
    5135                 5140                 5145             


Leu Val  Lys Asn Asp Pro Cys  Arg Val His His His  Gly Ser Lys 
    5150                 5155                 5160             


Met Leu  Arg Ser Glu Ser Asn  Ser Ser Ile Thr Thr  Thr Gln Pro 
    5165                 5170                 5175             


Thr Ile  Ala Lys Gly Arg Thr  Asn Met Glu Leu Arg  Glu Lys Phe 
    5180                 5185                 5190             


Ile Leu  Ala Asp Gly Ala Ser  Gln Gly Met Ala Ala  Phe Arg Pro 
    5195                 5200                 5205             


Arg Gly  Arg Arg Ser Arg Pro  Ser Ser Arg Gly Ala  Ser Pro Asn 
    5210                 5215                 5220             


Arg Ser  Thr Ser Val Ser Ser  Gln Ala Ala Gln Ala  Ala Ser Pro 
    5225                 5230                 5235             


Gln Val  Pro Ala Thr Thr Thr  Pro Lys Gly Thr Pro  Ile Gln Gly 
    5240                 5245                 5250             


Ser Lys  Leu Arg Leu Pro Gly  Tyr Leu Ser Gly Lys  Gly Phe His 
    5255                 5260                 5265             


Ser Gly  Glu Asp Ser Gly Leu  Ile Thr Thr Ala Ala  Ala Arg Val 
    5270                 5275                 5280             


Arg Thr  Gln Phe Ala Asp Ser  Lys Lys Thr Pro Ser  Arg Pro Gly 
    5285                 5290                 5295             


Ser Arg  Ala Gly Ser Lys Ala  Gly Ser Arg Ala Ser  Ser Arg Arg 
    5300                 5305                 5310             


Gly Ser  Asp Ala Ser Asp Phe  Asp Ile Ser Glu Ile  Gln Ser Val 
    5315                 5320                 5325             


Cys Ser  Asp Val Glu Thr Val  Pro Gln Thr His Arg  Pro Thr Pro 
    5330                 5335                 5340             


Arg Ala  Gly Ser Arg Pro Ser  Thr Ala Lys Pro Ser  Lys Ile Pro 
    5345                 5350                 5355             


Thr Pro  Gln Arg Lys Ser Pro  Ala Ser Lys Leu Asp  Lys Ser Ser 
    5360                 5365                 5370             


Lys Arg  
    5375 


<210>  4453
<211>  5497
<212>  PRT
<213>  Homo Sapiens

<400>  4453

Met Ala Gly Tyr Leu Ser Pro Ala Ala Tyr Leu Tyr Val Glu Glu Gln 
1               5                   10                  15      


Glu Tyr Leu Gln Ala Tyr Glu Asp Val Leu Glu Arg Tyr Lys Asp Glu 
            20                  25                  30          


Arg Asp Lys Val Gln Lys Lys Thr Phe Thr Lys Trp Ile Asn Gln His 
        35                  40                  45              


Leu Met Lys Val Arg Lys His Val Asn Asp Leu Tyr Glu Asp Leu Arg 
    50                  55                  60                  


Asp Gly His Asn Leu Ile Ser Leu Leu Glu Val Leu Ser Gly Asp Thr 
65                  70                  75                  80  


Leu Pro Arg Glu Lys Gly Arg Met Arg Phe His Arg Leu Gln Asn Val 
                85                  90                  95      


Gln Ile Ala Leu Asp Tyr Leu Lys Arg Arg Gln Val Lys Leu Val Asn 
            100                 105                 110         


Ile Arg Asn Asp Asp Ile Thr Asp Gly Asn Pro Lys Leu Thr Leu Gly 
        115                 120                 125             


Leu Ile Trp Thr Ile Ile Leu His Phe Gln Ile Ser Asp Ile His Val 
    130                 135                 140                 


Thr Gly Glu Ser Glu Asp Met Ser Ala Lys Glu Arg Leu Leu Leu Trp 
145                 150                 155                 160 


Thr Gln Gln Ala Thr Glu Gly Tyr Ala Gly Ile Arg Cys Glu Asn Phe 
                165                 170                 175     


Thr Thr Cys Trp Arg Asp Gly Lys Leu Phe Asn Ala Ile Ile His Lys 
            180                 185                 190         


Tyr Arg Pro Asp Leu Ile Asp Met Asn Thr Val Ala Val Gln Ser Asn 
        195                 200                 205             


Leu Ala Asn Leu Glu His Ala Phe Tyr Val Ala Glu Lys Ile Gly Val 
    210                 215                 220                 


Ile Arg Leu Leu Asp Pro Glu Asp Val Asp Val Ser Ser Pro Asp Glu 
225                 230                 235                 240 


Lys Ser Val Ile Thr Tyr Val Ser Ser Leu Tyr Asp Ala Phe Pro Lys 
                245                 250                 255     


Val Pro Glu Gly Gly Glu Gly Ile Gly Ala Asn Asp Val Glu Val Lys 
            260                 265                 270         


Trp Ile Glu Tyr Gln Asn Met Val Asn Tyr Leu Ile Gln Trp Ile Arg 
        275                 280                 285             


His His Val Thr Thr Met Ser Glu Arg Thr Phe Pro Asn Asn Pro Val 
    290                 295                 300                 


Glu Leu Lys Ala Leu Tyr Asn Gln Tyr Leu Gln Phe Lys Glu Thr Glu 
305                 310                 315                 320 


Ile Pro Pro Lys Glu Thr Glu Lys Ser Lys Ile Lys Arg Leu Tyr Lys 
                325                 330                 335     


Leu Leu Glu Ile Trp Ile Glu Phe Gly Arg Ile Lys Leu Leu Gln Gly 
            340                 345                 350         


Tyr His Pro Asn Asp Ile Glu Lys Glu Trp Gly Lys Leu Ile Ile Ala 
        355                 360                 365             


Met Leu Glu Arg Glu Lys Ala Leu Arg Pro Glu Val Glu Arg Leu Glu 
    370                 375                 380                 


Met Leu Gln Gln Ile Ala Asn Arg Val Gln Arg Asp Ser Val Ile Cys 
385                 390                 395                 400 


Glu Asp Lys Leu Ile Leu Ala Gly Asn Ala Leu Gln Ser Asp Ser Lys 
                405                 410                 415     


Arg Leu Glu Ser Gly Val Gln Phe Gln Asn Glu Ala Glu Ile Ala Gly 
            420                 425                 430         


Tyr Ile Leu Glu Cys Glu Asn Leu Leu Arg Gln His Val Ile Asp Val 
        435                 440                 445             


Gln Ile Leu Ile Asp Gly Lys Tyr Tyr Gln Ala Asp Gln Leu Val Gln 
    450                 455                 460                 


Arg Val Ala Lys Leu Arg Asp Glu Ile Met Ala Leu Arg Asn Glu Cys 
465                 470                 475                 480 


Ser Ser Val Tyr Ser Lys Gly Arg Ile Leu Thr Thr Glu Gln Thr Lys 
                485                 490                 495     


Leu Met Ile Ser Gly Ile Thr Gln Ser Leu Asn Ser Gly Phe Ala Gln 
            500                 505                 510         


Thr Leu His Pro Ser Leu Thr Ser Gly Leu Thr Gln Ser Leu Thr Pro 
        515                 520                 525             


Ser Leu Thr Ser Ser Ser Met Thr Ser Gly Leu Ser Ser Gly Met Thr 
    530                 535                 540                 


Ser Arg Leu Thr Pro Ser Val Thr Pro Ala Tyr Thr Pro Gly Phe Pro 
545                 550                 555                 560 


Ser Gly Leu Val Pro Asn Phe Ser Ser Gly Val Glu Pro Asn Ser Leu 
                565                 570                 575     


Gln Thr Leu Lys Leu Met Gln Ile Arg Lys Pro Leu Leu Lys Ser Ser 
            580                 585                 590         


Leu Leu Asp Gln Asn Leu Thr Glu Glu Glu Ile Asn Met Lys Phe Val 
        595                 600                 605             


Gln Asp Leu Leu Asn Trp Val Asp Glu Met Gln Val Gln Leu Asp Arg 
    610                 615                 620                 


Thr Glu Trp Gly Ser Asp Leu Pro Ser Val Glu Ser His Leu Glu Asn 
625                 630                 635                 640 


His Lys Asn Val His Arg Ala Ile Glu Glu Phe Glu Ser Ser Leu Lys 
                645                 650                 655     


Glu Ala Lys Ile Ser Glu Ile Gln Met Thr Ala Pro Leu Lys Leu Thr 
            660                 665                 670         


Tyr Ala Glu Lys Leu His Arg Leu Glu Ser Gln Tyr Ala Lys Leu Leu 
        675                 680                 685             


Asn Thr Ser Arg Asn Gln Glu Arg His Leu Asp Thr Leu His Asn Phe 
    690                 695                 700                 


Val Ser Arg Ala Thr Asn Glu Leu Ile Trp Leu Asn Glu Lys Glu Glu 
705                 710                 715                 720 


Glu Glu Val Ala Tyr Asp Trp Ser Glu Arg Asn Thr Asn Ile Ala Arg 
                725                 730                 735     


Lys Lys Asp Tyr His Ala Glu Leu Met Arg Glu Leu Asp Gln Lys Glu 
            740                 745                 750         


Glu Asn Ile Lys Ser Val Gln Glu Ile Ala Glu Gln Leu Leu Leu Glu 
        755                 760                 765             


Asn His Pro Ala Arg Leu Thr Ile Glu Ala Tyr Arg Ala Ala Met Gln 
    770                 775                 780                 


Thr Gln Trp Ser Trp Ile Leu Gln Leu Cys Gln Cys Val Glu Gln His 
785                 790                 795                 800 


Ile Lys Glu Asn Thr Ala Tyr Phe Glu Phe Phe Asn Asp Ala Lys Glu 
                805                 810                 815     


Ala Thr Asp Tyr Leu Arg Asn Leu Lys Asp Ala Ile Gln Arg Lys Tyr 
            820                 825                 830         


Ser Cys Asp Arg Ser Ser Ser Ile His Lys Leu Glu Asp Leu Val Gln 
        835                 840                 845             


Glu Ser Met Glu Glu Lys Glu Glu Leu Leu Gln Tyr Lys Ser Thr Ile 
    850                 855                 860                 


Ala Asn Leu Met Gly Lys Ala Lys Thr Ile Ile Gln Leu Lys Pro Arg 
865                 870                 875                 880 


Asn Ser Asp Cys Pro Leu Lys Thr Ser Ile Pro Ile Lys Ala Ile Cys 
                885                 890                 895     


Asp Tyr Arg Gln Ile Glu Ile Thr Ile Tyr Lys Asp Asp Glu Cys Val 
            900                 905                 910         


Leu Ala Asn Asn Ser His Arg Ala Lys Trp Lys Val Ile Ser Pro Thr 
        915                 920                 925             


Gly Asn Glu Ala Met Val Pro Ser Val Cys Phe Thr Val Pro Pro Pro 
    930                 935                 940                 


Asn Lys Glu Ala Val Asp Leu Ala Asn Arg Ile Glu Gln Gln Tyr Gln 
945                 950                 955                 960 


Asn Val Leu Thr Leu Trp His Glu Ser His Ile Asn Met Lys Ser Val 
                965                 970                 975     


Val Ser Trp His Tyr Leu Ile Asn Glu Ile Asp Arg Ile Arg Ala Ser 
            980                 985                 990         


Asn Val Ala Ser Ile Lys Thr Met  Leu Pro Gly Glu His  Gln Gln Val 
        995                 1000                 1005             


Leu Ser  Asn Leu Gln Ser Arg  Phe Glu Asp Phe Leu  Glu Asp Ser 
    1010                 1015                 1020             


Gln Glu  Ser Gln Val Phe Ser  Gly Ser Asp Ile Thr  Gln Leu Glu 
    1025                 1030                 1035             


Lys Glu  Val Asn Val Cys Lys  Gln Tyr Tyr Gln Glu  Leu Leu Lys 
    1040                 1045                 1050             


Ser Ala  Glu Arg Glu Glu Gln  Glu Glu Ser Val Tyr  Asn Leu Tyr 
    1055                 1060                 1065             


Ile Ser  Glu Val Arg Asn Ile  Arg Leu Arg Leu Glu  Asn Cys Glu 
    1070                 1075                 1080             


Asp Arg  Leu Ile Arg Gln Ile  Arg Thr Pro Leu Glu  Arg Asp Asp 
    1085                 1090                 1095             


Leu His  Glu Ser Val Phe Arg  Ile Thr Glu Gln Glu  Lys Leu Lys 
    1100                 1105                 1110             


Lys Glu  Leu Glu Arg Leu Lys  Asp Asp Leu Gly Thr  Ile Thr Asn 
    1115                 1120                 1125             


Lys Cys  Glu Glu Phe Phe Ser  Gln Ala Ala Ala Ser  Ser Ser Val 
    1130                 1135                 1140             


Pro Thr  Leu Arg Ser Glu Leu  Asn Val Val Leu Gln  Asn Met Asn 
    1145                 1150                 1155             


Gln Val  Tyr Ser Met Ser Ser  Thr Tyr Ile Asp Lys  Leu Lys Thr 
    1160                 1165                 1170             


Val Asn  Leu Val Leu Lys Asn  Thr Gln Ala Ala Glu  Ala Leu Val 
    1175                 1180                 1185             


Lys Leu  Tyr Glu Thr Lys Leu  Cys Glu Glu Glu Ala  Val Ile Ala 
    1190                 1195                 1200             


Asp Lys  Asn Asn Ile Glu Asn  Leu Ile Ser Thr Leu  Lys Gln Trp 
    1205                 1210                 1215             


Arg Ser  Glu Val Asp Glu Lys  Arg Gln Val Phe His  Ala Leu Glu 
    1220                 1225                 1230             


Asp Glu  Leu Gln Lys Ala Lys  Ala Ile Ser Asp Glu  Met Phe Lys 
    1235                 1240                 1245             


Thr Tyr  Lys Glu Arg Asp Leu  Asp Phe Asp Trp His  Lys Glu Lys 
    1250                 1255                 1260             


Ala Asp  Gln Leu Val Glu Arg  Trp Gln Asn Val His  Val Gln Ile 
    1265                 1270                 1275             


Asp Asn  Arg Leu Arg Asp Leu  Glu Gly Ile Gly Lys  Ser Leu Lys 
    1280                 1285                 1290             


Tyr Tyr  Arg Asp Thr Tyr His  Pro Leu Asp Asp Trp  Ile Gln Gln 
    1295                 1300                 1305             


Val Glu  Thr Thr Gln Arg Lys  Ile Gln Glu Asn Gln  Pro Glu Asn 
    1310                 1315                 1320             


Ser Lys  Thr Leu Ala Thr Gln  Leu Asn Gln Gln Lys  Met Leu Val 
    1325                 1330                 1335             


Ser Glu  Ile Glu Met Lys Gln  Ser Lys Met Asp Glu  Cys Gln Lys 
    1340                 1345                 1350             


Tyr Ala  Glu Gln Tyr Ser Ala  Thr Val Lys Asp Tyr  Glu Leu Gln 
    1355                 1360                 1365             


Thr Met  Thr Tyr Arg Ala Met  Val Asp Ser Gln Gln  Lys Ser Pro 
    1370                 1375                 1380             


Val Lys  Arg Arg Arg Met Gln  Ser Ser Ala Asp Leu  Ile Ile Gln 
    1385                 1390                 1395             


Glu Phe  Met Asp Leu Arg Thr  Arg Tyr Thr Ala Leu  Val Thr Leu 
    1400                 1405                 1410             


Met Thr  Gln Tyr Ile Lys Phe  Ala Gly Asp Ser Leu  Lys Arg Leu 
    1415                 1420                 1425             


Glu Glu  Glu Glu Lys Ser Leu  Glu Glu Glu Lys Lys  Glu His Val 
    1430                 1435                 1440             


Glu Lys  Ala Lys Glu Leu Gln  Lys Trp Val Ser Asn  Ile Ser Lys 
    1445                 1450                 1455             


Thr Leu  Lys Asp Ala Glu Lys  Ala Gly Lys Pro Pro  Phe Ser Lys 
    1460                 1465                 1470             


Gln Lys  Ile Ser Ser Glu Glu  Ile Ser Thr Lys Lys  Glu Gln Leu 
    1475                 1480                 1485             


Ser Glu  Ala Leu Gln Thr Ile  Gln Leu Phe Leu Ala  Lys His Gly 
    1490                 1495                 1500             


Asp Lys  Met Thr Asp Glu Glu  Arg Asn Glu Leu Glu  Lys Gln Val 
    1505                 1510                 1515             


Lys Thr  Leu Gln Glu Ser Tyr  Asn Leu Leu Phe Ser  Glu Ser Leu 
    1520                 1525                 1530             


Lys Gln  Leu Gln Glu Ser Gln  Thr Ser Gly Asp Val  Lys Val Glu 
    1535                 1540                 1545             


Glu Lys  Ile Val Ala Glu Arg  Gln Gln Glu Tyr Lys  Glu Lys Leu 
    1550                 1555                 1560             


Gln Gly  Ile Cys Asp Leu Leu  Thr Gln Thr Glu Asn  Arg Leu Ile 
    1565                 1570                 1575             


Gly His  Gln Glu Ala Phe Met  Ile Gly Asp Gly Thr  Val Glu Leu 
    1580                 1585                 1590             


Lys Lys  Tyr Gln Ser Lys Gln  Glu Glu Leu Gln Lys  Asp Met Gln 
    1595                 1600                 1605             


Gly Ser  Ala Gln Ala Leu Ala  Glu Val Val Lys Asn  Thr Glu Asn 
    1610                 1615                 1620             


Phe Leu  Lys Glu Asn Gly Glu  Lys Leu Ser Gln Glu  Asp Lys Ala 
    1625                 1630                 1635             


Leu Ile  Glu Gln Lys Leu Asn  Glu Ala Lys Ile Lys  Cys Glu Gln 
    1640                 1645                 1650             


Leu Asn  Leu Lys Ala Glu Gln  Ser Lys Lys Glu Leu  Asp Lys Val 
    1655                 1660                 1665             


Val Thr  Thr Ala Ile Lys Glu  Glu Thr Glu Lys Val  Ala Ala Val 
    1670                 1675                 1680             


Lys Gln  Leu Glu Glu Ser Lys  Thr Lys Ile Glu Asn  Leu Leu Asp 
    1685                 1690                 1695             


Trp Leu  Ser Asn Val Asp Lys  Asp Ser Glu Arg Ala  Gly Thr Lys 
    1700                 1705                 1710             


His Lys  Gln Val Ile Glu Gln  Asn Gly Thr His Phe  Gln Glu Gly 
    1715                 1720                 1725             


Asp Gly  Lys Ser Ala Ile Gly  Glu Glu Asp Glu Val  Asn Gly Asn 
    1730                 1735                 1740             


Leu Leu  Glu Thr Asp Val Asp  Gly Gln Val Gly Thr  Thr Gln Glu 
    1745                 1750                 1755             


Asn Leu  Asn Gln Gln Tyr Gln  Lys Val Lys Ala Gln  His Glu Lys 
    1760                 1765                 1770             


Ile Ile  Ser Gln His Gln Ala  Val Ile Ile Ala Thr  Gln Ser Ala 
    1775                 1780                 1785             


Gln Val  Leu Leu Glu Lys Gln  Gly Gln Tyr Leu Ser  Pro Glu Glu 
    1790                 1795                 1800             


Lys Glu  Lys Leu Gln Lys Asn  Met Lys Glu Leu Lys  Val His Tyr 
    1805                 1810                 1815             


Glu Thr  Ala Leu Ala Glu Ser  Glu Lys Lys Met Lys  Leu Thr His 
    1820                 1825                 1830             


Ser Leu  Gln Glu Glu Leu Glu  Lys Phe Asp Ala Asp  Tyr Thr Glu 
    1835                 1840                 1845             


Phe Glu  His Trp Leu Gln Gln  Ser Glu Gln Glu Leu  Glu Asn Leu 
    1850                 1855                 1860             


Glu Ala  Gly Ala Asp Asp Ile  Asn Gly Leu Met Thr  Lys Leu Lys 
    1865                 1870                 1875             


Arg Gln  Lys Ser Phe Ser Glu  Asp Val Ile Ser His  Lys Gly Asp 
    1880                 1885                 1890             


Leu Arg  Tyr Ile Thr Ile Ser  Gly Asn Arg Val Leu  Glu Ala Ala 
    1895                 1900                 1905             


Lys Ser  Cys Ser Lys Arg Asp  Gly Gly Lys Val Asp  Thr Ser Ala 
    1910                 1915                 1920             


Thr His  Arg Glu Val Gln Arg  Lys Leu Asp His Ala  Thr Asp Arg 
    1925                 1930                 1935             


Phe Arg  Ser Leu Tyr Ser Lys  Cys Asn Val Leu Gly  Asn Asn Leu 
    1940                 1945                 1950             


Lys Asp  Leu Val Asp Lys Tyr  Gln His Tyr Glu Asp  Ala Ser Cys 
    1955                 1960                 1965             


Gly Leu  Leu Ala Gly Leu Gln  Ala Cys Glu Ala Thr  Ala Ser Lys 
    1970                 1975                 1980             


His Leu  Ser Glu Pro Ile Ala  Val Asp Pro Lys Asn  Leu Gln Arg 
    1985                 1990                 1995             


Gln Leu  Glu Glu Thr Lys Ala  Leu Gln Gly Gln Ile  Ser Ser Gln 
    2000                 2005                 2010             


Gln Val  Ala Val Glu Lys Leu  Lys Lys Thr Ala Glu  Val Leu Leu 
    2015                 2020                 2025             


Asp Ala  Arg Gly Ser Leu Leu  Pro Ala Lys Asn Asp  Ile Gln Lys 
    2030                 2035                 2040             


Thr Leu  Asp Asp Ile Val Gly  Arg Tyr Glu Asp Leu  Ser Lys Ser 
    2045                 2050                 2055             


Val Asn  Glu Arg Asn Glu Lys  Leu Gln Ile Thr Leu  Thr Arg Ser 
    2060                 2065                 2070             


Leu Ser  Val Gln Asp Gly Leu  Asp Glu Met Leu Asp  Trp Met Gly 
    2075                 2080                 2085             


Asn Val  Glu Ser Ser Leu Lys  Glu Gln Gly Gln Val  Pro Leu Asn 
    2090                 2095                 2100             


Ser Thr  Ala Leu Gln Asp Ile  Ile Ser Lys Asn Ile  Met Leu Glu 
    2105                 2110                 2115             


Gln Asp  Ile Ala Gly Arg Gln  Ser Ser Ile Asn Ala  Met Asn Glu 
    2120                 2125                 2130             


Lys Val  Lys Lys Phe Met Glu  Thr Thr Asp Pro Ser  Thr Ala Ser 
    2135                 2140                 2145             


Ser Leu  Gln Ala Lys Met Lys  Asp Leu Ser Ala Arg  Phe Ser Glu 
    2150                 2155                 2160             


Ala Ser  His Lys His Lys Glu  Thr Leu Ala Lys Met  Glu Glu Leu 
    2165                 2170                 2175             


Lys Thr  Lys Val Glu Leu Phe  Glu Asn Leu Ser Glu  Lys Leu Gln 
    2180                 2185                 2190             


Thr Phe  Leu Glu Thr Lys Thr  Gln Ala Leu Thr Glu  Val Asp Val 
    2195                 2200                 2205             


Pro Gly  Lys Asp Val Thr Glu  Leu Ser Gln Tyr Met  Gln Glu Ser 
    2210                 2215                 2220             


Thr Ser  Glu Phe Leu Glu His  Lys Lys His Leu Glu  Val Leu His 
    2225                 2230                 2235             


Ser Leu  Leu Lys Glu Ile Ser  Ser His Gly Leu Pro  Ser Asp Lys 
    2240                 2245                 2250             


Ala Leu  Val Leu Glu Lys Thr  Asn Asn Leu Ser Lys  Lys Phe Lys 
    2255                 2260                 2265             


Glu Met  Glu Asp Thr Ile Lys  Glu Lys Lys Glu Ala  Val Thr Ser 
    2270                 2275                 2280             


Cys Gln  Glu Gln Leu Asp Ala  Phe Gln Val Leu Val  Lys Ser Leu 
    2285                 2290                 2295             


Lys Ser  Trp Ile Lys Glu Thr  Thr Lys Lys Val Pro  Ile Val Gln 
    2300                 2305                 2310             


Pro Ser  Phe Gly Ala Glu Asp  Leu Gly Lys Ser Leu  Glu Asp Thr 
    2315                 2320                 2325             


Lys Lys  Leu Gln Glu Lys Trp  Ser Leu Lys Thr Pro  Glu Ile Gln 
    2330                 2335                 2340             


Lys Val  Asn Asn Ser Gly Ile  Ser Leu Cys Asn Leu  Ile Ser Ala 
    2345                 2350                 2355             


Val Thr  Thr Pro Ala Lys Ala  Ile Ala Ala Val Lys  Ser Gly Gly 
    2360                 2365                 2370             


Ala Val  Leu Asn Gly Glu Gly  Thr Ala Thr Asn Thr  Glu Glu Phe 
    2375                 2380                 2385             


Trp Ala  Asn Lys Gly Leu Thr  Ser Ile Lys Lys Asp  Met Thr Asp 
    2390                 2395                 2400             


Ile Ser  His Gly Tyr Glu Asp  Leu Gly Leu Leu Leu  Lys Asp Lys 
    2405                 2410                 2415             


Ile Ala  Glu Leu Asn Thr Lys  Leu Ser Lys Leu Gln  Lys Ala Gln 
    2420                 2425                 2430             


Glu Glu  Ser Ser Ala Met Met  Gln Trp Leu Gln Lys  Met Asn Lys 
    2435                 2440                 2445             


Thr Ala  Thr Lys Trp Gln Gln  Thr Pro Ala Pro Thr  Asp Thr Glu 
    2450                 2455                 2460             


Ala Val  Lys Thr Gln Val Glu  Gln Asn Lys Ser Phe  Glu Ala Glu 
    2465                 2470                 2475             


Leu Lys  Gln Asn Val Asn Lys  Val Gln Glu Leu Lys  Asp Lys Leu 
    2480                 2485                 2490             


Thr Glu  Leu Leu Glu Glu Asn  Pro Asp Thr Pro Glu  Ala Pro Arg 
    2495                 2500                 2505             


Trp Lys  Gln Met Leu Thr Glu  Ile Asp Ser Lys Trp  Gln Glu Leu 
    2510                 2515                 2520             


Asn Gln  Leu Thr Ile Asp Arg  Gln Gln Lys Leu Glu  Glu Ser Ser 
    2525                 2530                 2535             


Asn Asn  Leu Thr Gln Phe Gln  Thr Val Glu Ala Gln  Leu Lys Gln 
    2540                 2545                 2550             


Trp Leu  Val Glu Lys Glu Leu  Met Val Ser Val Leu  Gly Pro Leu 
    2555                 2560                 2565             


Ser Ile  Asp Pro Asn Met Leu  Asn Thr Gln Arg Gln  Gln Val Gln 
    2570                 2575                 2580             


Ile Leu  Leu Gln Glu Phe Ala  Thr Arg Lys Pro Gln  Tyr Glu Gln 
    2585                 2590                 2595             


Leu Thr  Ala Ala Gly Gln Gly  Ile Leu Ser Arg Pro  Gly Glu Asp 
    2600                 2605                 2610             


Pro Ser  Leu Arg Gly Ile Val  Lys Glu Gln Leu Ala  Ala Val Thr 
    2615                 2620                 2625             


Gln Lys  Trp Asp Ser Leu Thr  Gly Gln Leu Ser Asp  Arg Cys Asp 
    2630                 2635                 2640             


Trp Ile  Asp Gln Ala Ile Val  Lys Ser Thr Gln Tyr  Gln Ser Leu 
    2645                 2650                 2655             


Leu Arg  Ser Leu Ser Asp Lys  Leu Ser Asp Leu Asp  Asn Lys Leu 
    2660                 2665                 2670             


Ser Ser  Ser Leu Ala Val Ser  Thr His Pro Asp Ala  Met Asn Gln 
    2675                 2680                 2685             


Gln Leu  Glu Thr Ala Gln Lys  Met Lys Gln Glu Ile  Gln Gln Glu 
    2690                 2695                 2700             


Lys Lys  Gln Ile Lys Val Ala  Gln Ala Leu Cys Glu  Asp Leu Ser 
    2705                 2710                 2715             


Ala Leu  Val Lys Glu Glu Tyr  Leu Lys Ala Glu Leu  Ser Arg Gln 
    2720                 2725                 2730             


Leu Glu  Gly Ile Leu Lys Ser  Phe Lys Asp Val Glu  Gln Lys Ala 
    2735                 2740                 2745             


Glu Asn  His Val Gln His Leu  Gln Ser Ala Cys Ala  Ser Ser His 
    2750                 2755                 2760             


Gln Phe  Gln Gln Met Ser Arg  Asp Phe Gln Ala Trp  Leu Asp Thr 
    2765                 2770                 2775             


Lys Lys  Glu Glu Gln Asn Lys  Ser His Pro Ile Ser  Ala Lys Leu 
    2780                 2785                 2790             


Asp Val  Leu Glu Ser Leu Ile  Lys Asp His Lys Asp  Phe Ser Lys 
    2795                 2800                 2805             


Thr Leu  Thr Ala Gln Ser His  Met Tyr Glu Lys Thr  Ile Ala Glu 
    2810                 2815                 2820             


Gly Glu  Asn Leu Leu Leu Lys  Thr Gln Gly Ser Glu  Lys Ala Ala 
    2825                 2830                 2835             


Leu Gln  Leu Gln Leu Asn Thr  Ile Lys Thr Asn Trp  Asp Thr Phe 
    2840                 2845                 2850             


Asn Lys  Gln Val Lys Glu Arg  Glu Asn Lys Leu Lys  Glu Ser Leu 
    2855                 2860                 2865             


Glu Lys  Ala Leu Lys Tyr Lys  Glu Gln Val Glu Thr  Leu Trp Pro 
    2870                 2875                 2880             


Trp Ile  Asp Lys Cys Gln Asn  Asn Leu Glu Glu Ile  Lys Phe Cys 
    2885                 2890                 2895             


Leu Asp  Pro Ala Glu Gly Glu  Asn Ser Ile Ala Lys  Leu Lys Ser 
    2900                 2905                 2910             


Leu Gln  Lys Glu Met Asp Gln  His Phe Gly Met Val  Glu Leu Leu 
    2915                 2920                 2925             


Asn Asn  Thr Ala Asn Ser Leu  Leu Ser Val Cys Glu  Ile Asp Lys 
    2930                 2935                 2940             


Glu Val  Val Thr Asp Glu Asn  Lys Ser Leu Ile Gln  Lys Val Asp 
    2945                 2950                 2955             


Met Val  Thr Glu Gln Leu His  Ser Lys Lys Phe Cys  Leu Glu Asn 
    2960                 2965                 2970             


Met Thr  Gln Lys Phe Lys Glu  Phe Gln Glu Val Ser  Lys Glu Ser 
    2975                 2980                 2985             


Lys Arg  Gln Leu Gln Cys Ala  Lys Glu Gln Leu Asp  Ile His Asp 
    2990                 2995                 3000             


Ser Leu  Gly Ser Gln Ala Tyr  Ser Asn Lys Tyr Leu  Thr Met Leu 
    3005                 3010                 3015             


Gln Thr  Gln Gln Lys Ser Leu  Gln Ala Leu Lys His  Gln Val Asp 
    3020                 3025                 3030             


Leu Ala  Lys Arg Leu Ala Gln  Asp Leu Val Val Glu  Ala Ser Asp 
    3035                 3040                 3045             


Ser Lys  Gly Thr Ser Asp Val  Leu Leu Gln Val Glu  Thr Ile Ala 
    3050                 3055                 3060             


Gln Glu  His Ser Thr Leu Ser  Gln Gln Val Asp Glu  Lys Cys Ser 
    3065                 3070                 3075             


Phe Leu  Glu Thr Lys Leu Gln  Gly Ile Gly His Phe  Gln Asn Thr 
    3080                 3085                 3090             


Ile Arg  Glu Met Phe Ser Gln  Phe Ala Glu Phe Asp  Asp Glu Leu 
    3095                 3100                 3105             


Asp Ser  Met Ala Pro Val Gly  Arg Asp Ala Glu Thr  Leu Gln Lys 
    3110                 3115                 3120             


Gln Lys  Glu Thr Ile Lys Ala  Phe Leu Lys Lys Leu  Glu Ala Leu 
    3125                 3130                 3135             


Met Ala  Ser Asn Asp Asn Ala  Asn Lys Thr Cys Lys  Met Met Leu 
    3140                 3145                 3150             


Ala Thr  Glu Glu Thr Ser Pro  Asp Leu Val Gly Ile  Lys Arg Asp 
    3155                 3160                 3165             


Leu Glu  Ala Leu Ser Lys Gln  Cys Asn Lys Leu Leu  Asp Arg Ala 
    3170                 3175                 3180             


Gln Ala  Arg Glu Glu Gln Val  Glu Gly Thr Ile Lys  Arg Leu Glu 
    3185                 3190                 3195             


Glu Phe  Tyr Ser Lys Leu Lys  Glu Phe Ser Ile Leu  Leu Gln Lys 
    3200                 3205                 3210             


Ala Glu  Glu His Glu Glu Ser  Gln Gly Pro Val Gly  Met Glu Thr 
    3215                 3220                 3225             


Glu Thr  Ile Asn Gln Gln Leu  Asn Met Phe Lys Val  Phe Gln Lys 
    3230                 3235                 3240             


Glu Glu  Ile Glu Pro Leu Gln  Gly Lys Gln Gln Asp  Val Asn Trp 
    3245                 3250                 3255             


Leu Gly  Gln Gly Leu Ile Gln  Ser Ala Ala Lys Ser  Thr Ser Thr 
    3260                 3265                 3270             


Gln Gly  Leu Glu His Asp Leu  Asp Asp Val Asn Ala  Arg Trp Lys 
    3275                 3280                 3285             


Thr Leu  Asn Lys Lys Val Ala  Gln Arg Ala Ala Gln  Leu Gln Glu 
    3290                 3295                 3300             


Ala Leu  Leu His Cys Gly Arg  Phe Gln Asp Ala Leu  Glu Ser Leu 
    3305                 3310                 3315             


Leu Ser  Trp Met Val Asp Thr  Glu Glu Leu Val Ala  Asn Gln Lys 
    3320                 3325                 3330             


Pro Pro  Ser Ala Glu Phe Lys  Val Val Lys Ala Gln  Ile Gln Glu 
    3335                 3340                 3345             


Gln Lys  Leu Leu Gln Arg Leu  Leu Asp Asp Arg Lys  Ser Thr Val 
    3350                 3355                 3360             


Glu Val  Ile Lys Arg Glu Gly  Glu Lys Ile Ala Thr  Thr Ala Glu 
    3365                 3370                 3375             


Pro Ala  Asp Lys Val Lys Ile  Leu Lys Gln Leu Ser  Leu Leu Asp 
    3380                 3385                 3390             


Ser Arg  Trp Glu Ala Leu Leu  Asn Lys Ala Glu Thr  Arg Asn Arg 
    3395                 3400                 3405             


Gln Leu  Glu Gly Ile Ser Val  Val Ala Gln Gln Phe  His Glu Thr 
    3410                 3415                 3420             


Leu Glu  Pro Leu Asn Glu Trp  Leu Thr Thr Ile Glu  Lys Arg Leu 
    3425                 3430                 3435             


Val Asn  Cys Glu Pro Ile Gly  Thr Gln Ala Ser Lys  Leu Glu Glu 
    3440                 3445                 3450             


Gln Ile  Ala Gln His Lys Ala  Leu Glu Asp Asp Ile  Ile Asn His 
    3455                 3460                 3465             


Asn Lys  His Leu His Gln Ala  Val Ser Ile Gly Gln  Ser Leu Lys 
    3470                 3475                 3480             


Val Leu  Ser Ser Arg Glu Asp  Lys Asp Met Val Gln  Ser Lys Leu 
    3485                 3490                 3495             


Asp Phe  Ser Gln Val Trp Tyr  Ile Glu Ile Gln Glu  Lys Ser His 
    3500                 3505                 3510             


Ser Arg  Ser Glu Leu Leu Gln  Gln Ala Leu Cys Asn  Ala Lys Ile 
    3515                 3520                 3525             


Phe Gly  Glu Asp Glu Val Glu  Leu Met Asn Trp Leu  Asn Glu Val 
    3530                 3535                 3540             


His Asp  Lys Leu Ser Lys Leu  Ser Val Gln Asp Tyr  Ser Thr Glu 
    3545                 3550                 3555             


Gly Leu  Trp Lys Gln Gln Ser  Glu Leu Arg Val Leu  Gln Glu Asp 
    3560                 3565                 3570             


Ile Leu  Leu Arg Lys Gln Asn  Val Asp Gln Ala Leu  Leu Asn Gly 
    3575                 3580                 3585             


Leu Glu  Leu Leu Lys Gln Thr  Thr Gly Asp Glu Val  Leu Ile Ile 
    3590                 3595                 3600             


Gln Asp  Lys Leu Glu Ala Ile  Lys Ala Arg Tyr Lys  Asp Ile Thr 
    3605                 3610                 3615             


Lys Leu  Ser Thr Asp Val Ala  Lys Thr Leu Glu Gln  Ala Leu Gln 
    3620                 3625                 3630             


Leu Ala  Arg Arg Leu His Ser  Thr His Glu Glu Leu  Cys Thr Trp 
    3635                 3640                 3645             


Leu Asp  Lys Val Glu Val Glu  Leu Leu Ser Tyr Glu  Thr Gln Val 
    3650                 3655                 3660             


Leu Lys  Gly Glu Glu Ala Ser  Gln Ala Gln Met Arg  Pro Lys Glu 
    3665                 3670                 3675             


Leu Lys  Lys Glu Ala Lys Asn  Asn Lys Ala Leu Leu  Asp Ser Leu 
    3680                 3685                 3690             


Asn Glu  Val Ser Ser Ala Leu  Leu Glu Leu Val Pro  Trp Arg Ala 
    3695                 3700                 3705             


Arg Glu  Gly Leu Glu Lys Met  Val Ala Glu Asp Asn  Glu Arg Tyr 
    3710                 3715                 3720             


Arg Leu  Val Ser Asp Thr Ile  Thr Gln Lys Val Glu  Glu Ile Asp 
    3725                 3730                 3735             


Ala Ala  Ile Leu Arg Ser Gln  Gln Phe Asp Gln Ala  Ala Asp Ala 
    3740                 3745                 3750             


Glu Leu  Ser Trp Ile Thr Glu  Thr Glu Lys Lys Leu  Met Ser Leu 
    3755                 3760                 3765             


Gly Asp  Ile Arg Leu Glu Gln  Asp Gln Thr Ser Ala  Gln Leu Gln 
    3770                 3775                 3780             


Val Gln  Lys Thr Phe Thr Met  Glu Ile Leu Arg His  Lys Asp Ile 
    3785                 3790                 3795             


Ile Asp  Asp Leu Val Lys Ser  Gly His Lys Ile Met  Thr Ala Cys 
    3800                 3805                 3810             


Ser Glu  Glu Glu Lys Gln Ser  Met Lys Lys Lys Leu  Asp Lys Val 
    3815                 3820                 3825             


Leu Lys  Asn Tyr Asp Thr Ile  Cys Gln Ile Asn Ser  Glu Arg Tyr 
    3830                 3835                 3840             


Leu Gln  Leu Glu Arg Ala Gln  Ser Leu Val Asn Gln  Phe Trp Glu 
    3845                 3850                 3855             


Thr Tyr  Glu Glu Leu Trp Pro  Trp Leu Thr Glu Thr  Gln Ser Ile 
    3860                 3865                 3870             


Ile Ser  Gln Leu Pro Ala Pro  Ala Leu Glu Tyr Glu  Thr Leu Arg 
    3875                 3880                 3885             


Gln Gln  Gln Glu Glu His Arg  Gln Leu Arg Glu Leu  Ile Ala Glu 
    3890                 3895                 3900             


His Lys  Pro His Ile Asp Lys  Met Asn Lys Thr Gly  Pro Gln Leu 
    3905                 3910                 3915             


Leu Glu  Leu Ser Pro Gly Glu  Gly Phe Ser Ile Gln  Glu Lys Tyr 
    3920                 3925                 3930             


Val Ala  Ala Asp Thr Leu Tyr  Ser Gln Ile Lys Glu  Asp Val Lys 
    3935                 3940                 3945             


Lys Arg  Ala Val Ala Leu Asp  Glu Ala Ile Ser Gln  Ser Thr Gln 
    3950                 3955                 3960             


Phe His  Asp Lys Ile Asp Gln  Ile Leu Glu Ser Leu  Glu Arg Ile 
    3965                 3970                 3975             


Val Glu  Arg Leu Arg Gln Pro  Pro Ser Ile Ser Ala  Glu Val Glu 
    3980                 3985                 3990             


Lys Ile  Lys Glu Gln Ile Ser  Glu Asn Lys Asn Val  Ser Val Asp 
    3995                 4000                 4005             


Met Glu  Lys Leu Gln Pro Leu  Tyr Glu Thr Leu Lys  Gln Arg Gly 
    4010                 4015                 4020             


Glu Glu  Met Ile Ala Arg Ser  Gly Gly Thr Asp Lys  Asp Ile Ser 
    4025                 4030                 4035             


Ala Lys  Ala Val Gln Asp Lys  Leu Asp Gln Met Val  Phe Ile Trp 
    4040                 4045                 4050             


Glu Asn  Ile His Thr Leu Val  Glu Glu Arg Glu Ala  Lys Leu Leu 
    4055                 4060                 4065             


Asp Val  Met Glu Leu Ala Glu  Lys Phe Trp Cys Asp  His Met Ser 
    4070                 4075                 4080             


Leu Ile  Val Thr Ile Lys Asp  Thr Gln Asp Phe Ile  Arg Asp Leu 
    4085                 4090                 4095             


Glu Asp  Pro Gly Ile Asp Pro  Ser Val Val Lys Gln  Gln Gln Glu 
    4100                 4105                 4110             


Ala Ala  Glu Thr Ile Arg Glu  Glu Ile Asp Gly Leu  Gln Glu Glu 
    4115                 4120                 4125             


Leu Asp  Ile Val Ile Asn Leu  Gly Ser Glu Leu Ile  Ala Ala Cys 
    4130                 4135                 4140             


Gly Glu  Pro Asp Lys Pro Ile  Val Lys Lys Ser Ile  Asp Glu Leu 
    4145                 4150                 4155             


Asn Ser  Ala Trp Asp Ser Leu  Asn Lys Ala Trp Lys  Asp Arg Ile 
    4160                 4165                 4170             


Asp Lys  Leu Glu Glu Ala Met  Gln Ala Ala Val Gln  Tyr Gln Asp 
    4175                 4180                 4185             


Gly Leu  Gln Ala Val Phe Asp  Trp Val Asp Ile Ala  Gly Gly Lys 
    4190                 4195                 4200             


Leu Ala  Ser Met Ser Pro Ile  Gly Thr Asp Leu Glu  Thr Val Lys 
    4205                 4210                 4215             


Gln Gln  Ile Glu Glu Leu Lys  Gln Phe Lys Ser Glu  Ala Tyr Gln 
    4220                 4225                 4230             


Gln Gln  Ile Glu Met Glu Arg  Leu Asn His Gln Ala  Glu Leu Leu 
    4235                 4240                 4245             


Leu Lys  Lys Val Thr Glu Glu  Ser Asp Lys His Thr  Val Gln Asp 
    4250                 4255                 4260             


Pro Leu  Met Glu Leu Lys Leu  Ile Trp Asp Ser Leu  Glu Glu Arg 
    4265                 4270                 4275             


Ile Ile  Asn Arg Gln His Lys  Leu Glu Gly Ala Leu  Leu Ala Leu 
    4280                 4285                 4290             


Gly Gln  Phe Gln His Ala Leu  Asp Glu Leu Leu Ala  Trp Leu Thr 
    4295                 4300                 4305             


His Thr  Glu Gly Leu Leu Ser  Glu Gln Lys Pro Val  Gly Gly Asp 
    4310                 4315                 4320             


Pro Lys  Ala Ile Glu Ile Glu  Leu Ala Lys His His  Val Leu Gln 
    4325                 4330                 4335             


Asn Asp  Val Leu Ala His Gln  Ser Thr Val Glu Ala  Val Asn Lys 
    4340                 4345                 4350             


Ala Gly  Asn Asp Leu Ile Glu  Ser Ser Ala Gly Glu  Glu Ala Ser 
    4355                 4360                 4365             


Asn Leu  Gln Asn Lys Leu Glu  Val Leu Asn Gln Arg  Trp Gln Asn 
    4370                 4375                 4380             


Val Leu  Glu Lys Thr Glu Gln  Arg Lys Gln Gln Leu  Asp Gly Ala 
    4385                 4390                 4395             


Leu Arg  Gln Ala Lys Gly Phe  His Gly Glu Ile Glu  Asp Leu Gln 
    4400                 4405                 4410             


Gln Trp  Leu Thr Asp Thr Glu  Arg His Leu Leu Ala  Ser Lys Pro 
    4415                 4420                 4425             


Leu Gly  Gly Leu Pro Glu Thr  Ala Lys Glu Gln Leu  Asn Val His 
    4430                 4435                 4440             


Met Glu  Val Cys Ala Ala Phe  Glu Ala Lys Glu Glu  Thr Tyr Lys 
    4445                 4450                 4455             


Ser Leu  Met Gln Lys Gly Gln  Gln Met Leu Ala Arg  Cys Pro Lys 
    4460                 4465                 4470             


Ser Ala  Glu Thr Asn Ile Asp  Gln Asp Ile Asn Asn  Leu Lys Glu 
    4475                 4480                 4485             


Lys Trp  Glu Ser Val Glu Thr  Lys Leu Asn Glu Arg  Lys Thr Lys 
    4490                 4495                 4500             


Leu Glu  Glu Ala Leu Asn Leu  Ala Met Glu Phe His  Asn Ser Leu 
    4505                 4510                 4515             


Gln Asp  Phe Ile Asn Trp Leu  Thr Gln Ala Glu Gln  Thr Leu Asn 
    4520                 4525                 4530             


Val Ala  Ser Arg Pro Ser Leu  Ile Leu Asp Thr Val  Leu Phe Gln 
    4535                 4540                 4545             


Ile Asp  Glu His Lys Val Phe  Ala Asn Glu Val Asn  Ser His Arg 
    4550                 4555                 4560             


Glu Gln  Ile Ile Glu Leu Asp  Lys Thr Gly Thr His  Leu Lys Tyr 
    4565                 4570                 4575             


Phe Ser  Gln Lys Gln Asp Val  Val Leu Ile Lys Asn  Leu Leu Ile 
    4580                 4585                 4590             


Ser Val  Gln Ser Arg Trp Glu  Lys Val Val Gln Arg  Leu Val Glu 
    4595                 4600                 4605             


Arg Gly  Arg Ser Leu Asp Asp  Ala Arg Lys Arg Ala  Lys Gln Phe 
    4610                 4615                 4620             


His Glu  Ala Trp Ser Lys Leu  Met Glu Trp Leu Glu  Glu Ser Glu 
    4625                 4630                 4635             


Lys Ser  Leu Asp Ser Glu Leu  Glu Ile Ala Asn Asp  Pro Asp Lys 
    4640                 4645                 4650             


Ile Lys  Thr Gln Leu Ala Gln  His Lys Glu Phe Gln  Lys Ser Leu 
    4655                 4660                 4665             


Gly Ala  Lys His Ser Val Tyr  Asp Thr Thr Asn Arg  Thr Gly Arg 
    4670                 4675                 4680             


Ser Leu  Lys Glu Lys Thr Ser  Leu Ala Asp Asp Asn  Leu Lys Leu 
    4685                 4690                 4695             


Asp Asp  Met Leu Ser Glu Leu  Arg Asp Lys Trp Asp  Thr Ile Cys 
    4700                 4705                 4710             


Gly Lys  Ser Val Glu Arg Gln  Asn Lys Leu Glu Glu  Ala Leu Leu 
    4715                 4720                 4725             


Phe Ser  Gly Gln Phe Thr Asp  Ala Leu Gln Ala Leu  Ile Asp Trp 
    4730                 4735                 4740             


Leu Tyr  Arg Val Glu Pro Gln  Leu Ala Glu Asp Gln  Pro Val His 
    4745                 4750                 4755             


Gly Asp  Ile Asp Leu Val Met  Asn Leu Ile Asp Asn  His Lys Ala 
    4760                 4765                 4770             


Phe Gln  Lys Glu Leu Gly Lys  Arg Thr Ser Ser Val  Gln Ala Leu 
    4775                 4780                 4785             


Lys Arg  Ser Ala Arg Glu Leu  Ile Glu Gly Ser Arg  Asp Asp Ser 
    4790                 4795                 4800             


Ser Trp  Val Lys Val Gln Met  Gln Glu Leu Ser Thr  Arg Trp Glu 
    4805                 4810                 4815             


Thr Val  Cys Ala Leu Ser Ile  Ser Lys Gln Thr Arg  Leu Glu Ala 
    4820                 4825                 4830             


Ala Leu  Arg Gln Ala Glu Glu  Phe His Ser Val Val  His Ala Leu 
    4835                 4840                 4845             


Leu Glu  Trp Leu Ala Glu Ala  Glu Gln Thr Leu Arg  Phe His Gly 
    4850                 4855                 4860             


Val Leu  Pro Asp Asp Glu Asp  Ala Leu Arg Thr Leu  Ile Asp Gln 
    4865                 4870                 4875             


His Lys  Glu Phe Met Lys Lys  Leu Glu Glu Lys Arg  Ala Glu Leu 
    4880                 4885                 4890             


Asn Lys  Ala Thr Thr Met Gly  Asp Thr Val Leu Ala  Ile Cys His 
    4895                 4900                 4905             


Pro Asp  Ser Ile Thr Thr Ile  Lys His Trp Ile Thr  Ile Ile Arg 
    4910                 4915                 4920             


Ala Arg  Phe Glu Glu Val Leu  Ala Trp Ala Lys Gln  His Gln Gln 
    4925                 4930                 4935             


Arg Leu  Ala Ser Ala Leu Ala  Gly Leu Ile Ala Lys  Gln Glu Leu 
    4940                 4945                 4950             


Leu Glu  Ala Leu Leu Ala Trp  Leu Gln Trp Ala Glu  Thr Thr Leu 
    4955                 4960                 4965             


Thr Asp  Lys Asp Lys Glu Val  Ile Pro Gln Glu Ile  Glu Glu Val 
    4970                 4975                 4980             


Lys Ala  Leu Ile Ala Glu His  Gln Thr Phe Met Glu  Glu Met Thr 
    4985                 4990                 4995             


Arg Lys  Gln Pro Asp Val Asp  Lys Val Thr Lys Thr  Tyr Lys Arg 
    5000                 5005                 5010             


Arg Ala  Ala Asp Pro Ser Ser  Leu Gln Ser His Ile  Pro Val Leu 
    5015                 5020                 5025             


Asp Lys  Gly Arg Ala Gly Arg  Lys Arg Phe Pro Ala  Ser Ser Leu 
    5030                 5035                 5040             


Tyr Pro  Ser Gly Ser Gln Thr  Gln Ile Glu Thr Lys  Asn Pro Arg 
    5045                 5050                 5055             


Val Asn  Leu Leu Val Ser Lys  Trp Gln Gln Val Trp  Leu Leu Ala 
    5060                 5065                 5070             


Leu Glu  Arg Arg Arg Lys Leu  Asn Asp Ala Leu Asp  Arg Leu Glu 
    5075                 5080                 5085             


Glu Leu  Arg Glu Phe Ala Asn  Phe Asp Phe Asp Ile  Trp Arg Lys 
    5090                 5095                 5100             


Lys Tyr  Met Arg Trp Met Asn  His Lys Lys Ser Arg  Val Met Asp 
    5105                 5110                 5115             


Phe Phe  Arg Arg Ile Asp Lys  Asp Gln Asp Gly Lys  Ile Thr Arg 
    5120                 5125                 5130             


Gln Glu  Phe Ile Asp Gly Ile  Leu Ser Ser Lys Phe  Pro Thr Ser 
    5135                 5140                 5145             


Arg Leu  Glu Met Ser Ala Val  Ala Asp Ile Phe Asp  Arg Asp Gly 
    5150                 5155                 5160             


Asp Gly  Tyr Ile Asp Tyr Tyr  Glu Phe Val Ala Ala  Leu His Pro 
    5165                 5170                 5175             


Asn Lys  Asp Ala Tyr Lys Pro  Ile Thr Asp Ala Asp  Lys Ile Glu 
    5180                 5185                 5190             


Asp Glu  Val Thr Arg Gln Val  Ala Lys Cys Lys Cys  Ala Lys Arg 
    5195                 5200                 5205             


Phe Gln  Val Glu Gln Ile Gly  Asp Asn Lys Tyr Arg  Phe Phe Leu 
    5210                 5215                 5220             


Gly Asn  Gln Phe Gly Asp Ser  Gln Gln Leu Arg Leu  Val Arg Ile 
    5225                 5230                 5235             


Leu Arg  Ser Thr Val Met Val  Arg Val Gly Gly Gly  Trp Met Ala 
    5240                 5245                 5250             


Leu Asp  Glu Phe Leu Val Lys  Asn Asp Pro Cys Arg  Ala Lys Gly 
    5255                 5260                 5265             


Arg Thr  Asn Met Glu Leu Arg  Glu Lys Phe Ile Leu  Ala Asp Gly 
    5270                 5275                 5280             


Ala Ser  Gln Gly Met Ala Ala  Phe Arg Pro Arg Gly  Arg Arg Ser 
    5285                 5290                 5295             


Arg Pro  Ser Ser Arg Gly Ala  Ser Pro Asn Arg Ser  Thr Ser Val 
    5300                 5305                 5310             


Ser Ser  Gln Ala Ala Gln Ala  Ala Ser Pro Gln Val  Pro Ala Thr 
    5315                 5320                 5325             


Thr Thr  Pro Lys Ile Leu His  Pro Leu Thr Arg Asn  Tyr Gly Lys 
    5330                 5335                 5340             


Pro Trp  Leu Thr Asn Ser Lys  Met Ser Thr Pro Cys  Lys Ala Ala 
    5345                 5350                 5355             


Glu Cys  Ser Asp Phe Pro Val  Pro Ser Ala Glu Gly  Thr Pro Ile 
    5360                 5365                 5370             


Gln Gly  Ser Lys Leu Arg Leu  Pro Gly Tyr Leu Ser  Gly Lys Gly 
    5375                 5380                 5385             


Phe His  Ser Gly Glu Asp Ser  Gly Leu Ile Thr Thr  Ala Ala Ala 
    5390                 5395                 5400             


Arg Val  Arg Thr Gln Phe Ala  Asp Ser Lys Lys Thr  Pro Ser Arg 
    5405                 5410                 5415             


Pro Gly  Ser Arg Ala Gly Ser  Lys Ala Gly Ser Arg  Ala Ser Ser 
    5420                 5425                 5430             


Arg Arg  Gly Ser Asp Ala Ser  Asp Phe Asp Ile Ser  Glu Ile Gln 
    5435                 5440                 5445             


Ser Val  Cys Ser Asp Val Glu  Thr Val Pro Gln Thr  His Arg Pro 
    5450                 5455                 5460             


Thr Pro  Arg Ala Gly Ser Arg  Pro Ser Thr Ala Lys  Pro Ser Lys 
    5465                 5470                 5475             


Ile Pro  Thr Pro Gln Arg Lys  Ser Pro Ala Ser Lys  Leu Asp Lys 
    5480                 5485                 5490             


Ser Ser  Lys Arg 
    5495         


<210>  4454
<211>  1674
<212>  PRT
<213>  Homo Sapiens

<400>  4454

Met Gly Lys Pro Leu Ser Arg Pro Asp Cys Leu Arg Gln Asn Pro Pro 
1               5                   10                  15      


Cys Val Gly Lys Gly Glu Glu Glu Glu Asp Leu Asn Ile Glu Asp Cys 
            20                  25                  30          


Tyr Val Pro Gln Arg Ser Ile Tyr Asp Thr Val Arg Leu Asn Glu Gln 
        35                  40                  45              


Ile Asp Ser Gly Ser Lys Gly Ser Leu Ser Ser Arg His Phe Thr Asp 
    50                  55                  60                  


Arg Thr Leu Pro Tyr Ser His Arg Thr Leu Asp Val Ser Ser Leu Cys 
65                  70                  75                  80  


Ser Asn Gly Ala Leu Thr Ser Ser Ser Val Phe Glu Leu Arg Gly Arg 
                85                  90                  95      


Glu Ala Asn Lys Leu Asp Glu Lys Met Ile Phe Asp Ala Leu Lys Leu 
            100                 105                 110         


Asn Ser Asp Ile Ile Arg Thr Thr Gly Leu Pro Lys Ala Lys Ser His 
        115                 120                 125             


Ala Glu Lys Lys Glu His Arg Arg Ser Trp Arg Met Phe Val Pro Ala 
    130                 135                 140                 


Asn Phe Met Asp Tyr Ala Asn Lys Ser Glu Ser Ser Phe Val Glu Pro 
145                 150                 155                 160 


Ala Asp Met Ser Asp Ala Val Thr Lys Ala Ser Lys Cys Arg Trp Gly 
                165                 170                 175     


Thr Asn Ser Leu Thr Ser Glu Glu Asp Asp Ser Gly Leu Cys Ser Pro 
            180                 185                 190         


Pro Ala Glu Arg Glu Glu Lys Gln Gly Ile Leu Thr Gly Asp Gln Ser 
        195                 200                 205             


Arg Ile Lys Ser Leu Ser Ser Thr Glu Asp Ile Leu Val Thr Asp Gln 
    210                 215                 220                 


Tyr Arg Pro Phe Phe Ser Val Asn Ser Ile Ser Glu Gln Lys Ile Pro 
225                 230                 235                 240 


Leu Leu Ser Cys Gln Ser Ala His Pro Asp Glu Asn Phe Lys Met Ile 
                245                 250                 255     


Leu His Asp Val Ser Pro Leu Glu Glu Ala Lys His Val Asn Gly Gln 
            260                 265                 270         


Arg Glu Ile His Asp Glu Asn Cys Cys Leu Gln Asn Asn Leu Lys Glu 
        275                 280                 285             


Ser Pro Val Lys Cys Asp Pro Leu Ile Met Pro Arg Asn Arg Glu Asn 
    290                 295                 300                 


Glu His Ile Phe Asn Leu Gly Glu Glu Asp Glu Thr Tyr Gly Pro Gly 
305                 310                 315                 320 


Glu Ser Gln Ile Thr Ala Gln Ser Arg Glu Leu Leu Lys Asp Ser Pro 
                325                 330                 335     


Gln Asp Leu Asp Leu Ser His Thr Asp Leu Gly Glu Ser Asp Val Asp 
            340                 345                 350         


Cys Gly Ser Thr Ser Leu Val Glu Asn Val Thr Leu Leu Thr Gln Tyr 
        355                 360                 365             


Asp Ser Gly Glu Cys Asn Ile Ala Ser Lys Glu Glu Val Glu Ala Pro 
    370                 375                 380                 


Leu Ser Ala Gln Glu Ser Glu Met Leu Tyr Lys Lys Phe Ser Leu Lys 
385                 390                 395                 400 


Phe Val Ser Ala Arg Lys Lys Ala Ala Pro Arg Lys Thr Gly Ala Gln 
                405                 410                 415     


Ala Gly Ile Leu Asp Thr Val Cys Asn Gly Phe Gln Leu Val Gln Val 
            420                 425                 430         


Phe Gln Lys Glu Glu Ile Glu Pro Leu Gln Gly Lys Gln Gln Asp Val 
        435                 440                 445             


Asn Trp Leu Gly Gln Gly Leu Ile Gln Ser Ala Ala Lys Ser Thr Ser 
    450                 455                 460                 


Thr Gln Gly Leu Glu His Asp Leu Asp Asp Val Asn Ala Arg Trp Lys 
465                 470                 475                 480 


Thr Leu Asn Lys Lys Val Ala Gln Arg Ala Ala Gln Leu Gln Glu Ala 
                485                 490                 495     


Leu Leu His Cys Gly Arg Phe Gln Asp Ala Leu Glu Ser Leu Leu Ser 
            500                 505                 510         


Trp Met Val Asp Thr Glu Glu Leu Val Ala Asn Gln Lys Pro Pro Ser 
        515                 520                 525             


Ala Glu Phe Lys Val Val Lys Ala Gln Ile Gln Glu Gln Lys Leu Leu 
    530                 535                 540                 


Gln Arg Leu Leu Asp Asp Arg Lys Ser Thr Val Glu Val Ile Lys Arg 
545                 550                 555                 560 


Glu Gly Glu Lys Ile Ala Thr Thr Ala Glu Pro Ala Asp Lys Val Lys 
                565                 570                 575     


Ile Leu Lys Gln Leu Ser Leu Leu Asp Ser Arg Trp Glu Ala Leu Leu 
            580                 585                 590         


Asn Lys Ala Glu Thr Arg Asn Arg Gln Leu Glu Gly Ile Ser Val Val 
        595                 600                 605             


Ala Gln Gln Phe His Glu Thr Leu Glu Pro Leu Asn Glu Trp Leu Thr 
    610                 615                 620                 


Thr Ile Glu Lys Arg Leu Val Asn Cys Glu Pro Ile Gly Thr Gln Ala 
625                 630                 635                 640 


Ser Lys Leu Glu Glu Gln Ile Ala Gln His Lys Ala Leu Glu Asp Asp 
                645                 650                 655     


Ile Ile Asn His Asn Lys His Leu His Gln Ala Val Ser Ile Gly Gln 
            660                 665                 670         


Ser Leu Lys Val Leu Ser Ser Arg Glu Asp Lys Asp Met Val Gln Ser 
        675                 680                 685             


Lys Leu Asp Phe Ser Gln Val Trp Tyr Ile Glu Ile Gln Glu Lys Ser 
    690                 695                 700                 


His Ser Arg Ser Glu Leu Leu Gln Gln Ala Leu Cys Asn Ala Lys Ile 
705                 710                 715                 720 


Phe Gly Glu Asp Glu Val Glu Leu Met Asn Trp Leu Asn Glu Val His 
                725                 730                 735     


Asp Lys Leu Ser Lys Leu Ser Val Gln Asp Tyr Ser Thr Glu Gly Leu 
            740                 745                 750         


Trp Lys Gln Gln Ser Glu Leu Arg Val Leu Gln Glu Asp Ile Leu Leu 
        755                 760                 765             


Arg Lys Gln Asn Val Asp Gln Ala Leu Leu Asn Gly Leu Glu Leu Leu 
    770                 775                 780                 


Lys Gln Thr Thr Gly Asp Glu Val Leu Ile Ile Gln Asp Lys Leu Glu 
785                 790                 795                 800 


Ala Ile Lys Ala Arg Tyr Lys Asp Ile Thr Lys Leu Ser Thr Asp Val 
                805                 810                 815     


Ala Lys Thr Leu Glu Gln Ala Leu Gln Leu Ala Arg Arg Leu His Ser 
            820                 825                 830         


Thr His Glu Glu Leu Cys Thr Trp Leu Asp Lys Val Glu Val Glu Leu 
        835                 840                 845             


Leu Ser Tyr Glu Thr Gln Val Leu Lys Gly Glu Glu Ala Ser Gln Ala 
    850                 855                 860                 


Gln Met Arg Pro Lys Glu Leu Lys Lys Glu Ala Lys Asn Asn Lys Ala 
865                 870                 875                 880 


Leu Leu Asp Ser Leu Asn Glu Val Ser Ser Ala Leu Leu Glu Leu Val 
                885                 890                 895     


Pro Trp Arg Ala Arg Glu Gly Leu Glu Lys Met Val Ala Glu Asp Asn 
            900                 905                 910         


Glu Arg Tyr Arg Leu Val Ser Asp Thr Ile Thr Gln Lys Val Glu Glu 
        915                 920                 925             


Ile Asp Ala Ala Ile Leu Arg Ser Gln Gln Phe Asp Gln Ala Ala Asp 
    930                 935                 940                 


Ala Glu Leu Ser Trp Ile Thr Glu Thr Glu Lys Lys Leu Met Ser Leu 
945                 950                 955                 960 


Gly Asp Ile Arg Leu Glu Gln Asp Gln Thr Ser Ala Gln Leu Gln Val 
                965                 970                 975     


Gln Lys Thr Phe Thr Met Glu Ile Leu Arg His Lys Asp Ile Ile Asp 
            980                 985                 990         


Asp Leu Val Lys Ser Gly His Lys  Ile Met Thr Ala Cys  Ser Glu Glu 
        995                 1000                 1005             


Glu Lys  Gln Ser Met Lys Lys  Lys Leu Asp Lys Val  Leu Lys Asn 
    1010                 1015                 1020             


Tyr Asp  Thr Ile Cys Gln Ile  Asn Ser Glu Arg Tyr  Leu Gln Leu 
    1025                 1030                 1035             


Glu Arg  Ala Gln Ser Leu Val  Asn Gln Phe Trp Glu  Thr Tyr Glu 
    1040                 1045                 1050             


Glu Leu  Trp Pro Trp Leu Thr  Glu Thr Gln Ser Ile  Ile Ser Gln 
    1055                 1060                 1065             


Leu Pro  Ala Pro Ala Leu Glu  Tyr Glu Thr Leu Arg  Gln Gln Gln 
    1070                 1075                 1080             


Glu Glu  His Arg Gln Leu Arg  Glu Leu Ile Ala Glu  His Lys Pro 
    1085                 1090                 1095             


His Ile  Asp Lys Met Asn Lys  Thr Gly Pro Gln Leu  Leu Glu Leu 
    1100                 1105                 1110             


Ser Pro  Gly Glu Gly Phe Ser  Ile Gln Glu Lys Tyr  Val Ala Ala 
    1115                 1120                 1125             


Asp Thr  Leu Tyr Ser Gln Ile  Lys Glu Asp Val Lys  Lys Arg Ala 
    1130                 1135                 1140             


Val Ala  Leu Asp Glu Ala Ile  Ser Gln Ser Thr Gln  Phe His Asp 
    1145                 1150                 1155             


Lys Ile  Asp Gln Ile Leu Glu  Ser Leu Glu Arg Ile  Val Glu Arg 
    1160                 1165                 1170             


Leu Arg  Gln Pro Pro Ser Ile  Ser Ala Glu Val Glu  Lys Ile Lys 
    1175                 1180                 1185             


Glu Gln  Ile Ser Glu Asn Lys  Asn Val Ser Val Asp  Met Glu Lys 
    1190                 1195                 1200             


Leu Gln  Pro Leu Tyr Glu Thr  Leu Lys Gln Arg Gly  Glu Glu Met 
    1205                 1210                 1215             


Ile Ala  Arg Ser Gly Gly Thr  Asp Lys Asp Ile Ser  Ala Lys Ala 
    1220                 1225                 1230             


Val Gln  Asp Lys Leu Asp Gln  Met Val Phe Ile Trp  Glu Asn Ile 
    1235                 1240                 1245             


His Thr  Leu Val Glu Glu Arg  Glu Ala Lys Leu Leu  Asp Val Met 
    1250                 1255                 1260             


Glu Leu  Ala Glu Lys Phe Trp  Cys Asp His Met Ser  Leu Ile Val 
    1265                 1270                 1275             


Thr Ile  Lys Asp Thr Gln Asp  Phe Ile Arg Asp Leu  Glu Asp Pro 
    1280                 1285                 1290             


Gly Ile  Asp Pro Ser Val Val  Lys Gln Gln Gln Glu  Ala Ala Glu 
    1295                 1300                 1305             


Thr Ile  Arg Glu Glu Ile Asp  Gly Leu Gln Glu Glu  Leu Asp Ile 
    1310                 1315                 1320             


Val Ile  Asn Leu Gly Ser Glu  Leu Ile Ala Ala Cys  Gly Glu Pro 
    1325                 1330                 1335             


Asp Lys  Pro Ile Val Lys Lys  Ser Ile Asp Glu Leu  Asn Ser Ala 
    1340                 1345                 1350             


Trp Asp  Ser Leu Asn Lys Ala  Trp Lys Asp Arg Ile  Asp Lys Leu 
    1355                 1360                 1365             


Glu Glu  Ala Met Gln Ala Ala  Val Gln Tyr Gln Asp  Gly Leu Gln 
    1370                 1375                 1380             


Ala Val  Phe Asp Trp Val Asp  Ile Ala Gly Gly Lys  Leu Ala Ser 
    1385                 1390                 1395             


Met Ser  Pro Ile Gly Thr Asp  Leu Glu Thr Val Lys  Gln Gln Ile 
    1400                 1405                 1410             


Glu Glu  Leu Lys Gln Phe Lys  Ser Glu Ala Tyr Gln  Gln Gln Ile 
    1415                 1420                 1425             


Glu Met  Glu Arg Leu Asn His  Gln Ala Glu Leu Leu  Leu Lys Lys 
    1430                 1435                 1440             


Val Thr  Glu Glu Ser Asp Lys  His Thr Val Gln Asp  Pro Leu Met 
    1445                 1450                 1455             


Glu Leu  Lys Leu Ile Trp Asp  Ser Leu Glu Glu Arg  Ile Ile Asn 
    1460                 1465                 1470             


Arg Gln  His Lys Leu Glu Gly  Ala Leu Leu Ala Leu  Gly Gln Phe 
    1475                 1480                 1485             


Gln His  Ala Leu Asp Glu Leu  Leu Ala Trp Leu Thr  His Thr Glu 
    1490                 1495                 1500             


Gly Leu  Leu Ser Glu Gln Lys  Pro Val Gly Gly Asp  Pro Lys Ala 
    1505                 1510                 1515             


Ile Glu  Ile Glu Leu Ala Lys  His His Val Leu Gln  Asn Asp Val 
    1520                 1525                 1530             


Leu Ala  His Gln Ser Thr Val  Glu Ala Val Asn Lys  Ala Gly Asn 
    1535                 1540                 1545             


Asp Leu  Ile Glu Ser Ser Ala  Gly Glu Glu Ala Ser  Asn Leu Gln 
    1550                 1555                 1560             


Asn Lys  Leu Glu Val Leu Asn  Gln Arg Trp Gln Asn  Val Leu Glu 
    1565                 1570                 1575             


Lys Thr  Glu Gln Arg Lys Gln  Gln Leu Asp Gly Ala  Leu Arg Gln 
    1580                 1585                 1590             


Ala Lys  Gly Phe His Gly Glu  Ile Glu Asp Leu Gln  Gln Trp Leu 
    1595                 1600                 1605             


Thr Asp  Thr Glu Arg His Leu  Leu Ala Ser Lys Pro  Leu Gly Gly 
    1610                 1615                 1620             


Leu Pro  Glu Thr Ala Lys Glu  Gln Leu Asn Val His  Met Glu Val 
    1625                 1630                 1635             


Cys Ala  Ala Phe Glu Ala Lys  Glu Glu Thr Tyr Lys  Ser Leu Met 
    1640                 1645                 1650             


Gln Lys  Gly Gln Gln Met Leu  Ala Arg Cys Pro Lys  Ser Ala Glu 
    1655                 1660                 1665             


Thr Asn  Ile Asp Gln Asp 
    1670                 


<210>  4455
<211>  304
<212>  PRT
<213>  Homo Sapiens

<400>  4455

Met Gly Asn Val Cys Gly Cys Val Arg Ala Glu Lys Glu Glu Gln Tyr 
1               5                   10                  15      


Val Asp Pro Ala Lys Thr Pro Leu Asn Pro Glu Lys Tyr Ser Pro Gly 
            20                  25                  30          


Arg Lys Tyr Phe Arg Arg Lys Pro Ile Lys Lys Thr Gly Gly Asp Lys 
        35                  40                  45              


Glu Ser Val Gly Ala Asn Asn Glu Asn Glu Gly Lys Lys Lys Ser Ser 
    50                  55                  60                  


Ser Gln Pro Ser Lys Glu Gln Pro Ala Pro Leu Ser Arg Gly Leu Val 
65                  70                  75                  80  


Gln Gln Glu Ser Val Thr Leu Asn Ser Ala Leu Gly Asp Gly Ile Gln 
                85                  90                  95      


Gln Lys Lys Thr Glu Val Val Ala Asp Ser Val Lys Gln Lys Leu Leu 
            100                 105                 110         


Pro Ser Ala Val Ser Ser Trp Ser Asp Cys Val Asn Thr Ser Pro Ala 
        115                 120                 125             


Lys Asp Ser Glu Thr Glu Val Lys Val Ser Glu Leu Asp Glu Arg Ile 
    130                 135                 140                 


Ser Glu Lys Asp Ser Thr Pro Tyr Cys Ala Lys Arg Lys Lys His Leu 
145                 150                 155                 160 


Asp Asp Val Asn Thr Ser Glu Ile Thr Phe Gln Glu Lys Thr Asp Val 
                165                 170                 175     


Phe Ser Phe Arg Lys Ala Ala Ser Leu Ser Ser Ile Pro Ser Gly Ile 
            180                 185                 190         


Glu Arg Ser Leu Glu Lys Ser Gly Phe Pro Glu Asp Pro Pro Lys Ser 
        195                 200                 205             


Tyr Ser Ser Ile Gln Glu Lys Gln Asn Thr Glu Arg Phe Cys Pro His 
    210                 215                 220                 


Ala Thr Gln His Phe Gln Phe Lys Lys Lys Arg Cys His Ser Leu Tyr 
225                 230                 235                 240 


Thr Ser Met Ser Ser Val Ser Lys Asp Thr Asp Gly Asn Glu Ile Ser 
                245                 250                 255     


Asp Ile His Val Thr Gly Glu Ser Glu Asp Met Ser Ala Lys Glu Arg 
            260                 265                 270         


Leu Leu Leu Trp Thr Gln Gln Ala Thr Glu Gly Tyr Ala Gly Ile Arg 
        275                 280                 285             


Cys Glu Asn Phe Thr Thr Cys Trp Arg Asp Gly Lys Leu Phe Asn Ala 
    290                 295                 300                 


<210>  4456
<211>  5171
<212>  PRT
<213>  Homo Sapiens

<400>  4456

Met His Ser Ser Ser Tyr Ser Tyr Arg Ser Ser Asp Ser Val Phe Ser 
1               5                   10                  15      


Asn Thr Thr Ser Thr Arg Thr Ser Leu Asp Ser Asn Glu Asn Leu Leu 
            20                  25                  30          


Leu Val His Cys Gly Pro Thr Leu Ile Asn Ser Cys Ile Ser Phe Gly 
        35                  40                  45              


Ser Glu Ser Phe Asp Gly His Arg Leu Glu Met Leu Gln Gln Ile Ala 
    50                  55                  60                  


Asn Arg Val Gln Arg Asp Ser Val Ile Cys Glu Asp Lys Leu Ile Leu 
65                  70                  75                  80  


Ala Gly Asn Ala Leu Gln Ser Asp Ser Lys Arg Leu Glu Ser Gly Val 
                85                  90                  95      


Gln Phe Gln Asn Glu Ala Glu Ile Ala Gly Tyr Ile Leu Glu Cys Glu 
            100                 105                 110         


Asn Leu Leu Arg Gln His Val Ile Asp Val Gln Ile Leu Ile Asp Gly 
        115                 120                 125             


Lys Tyr Tyr Gln Ala Asp Gln Leu Val Gln Arg Val Ala Lys Leu Arg 
    130                 135                 140                 


Asp Glu Ile Met Ala Leu Arg Asn Glu Cys Ser Ser Val Tyr Ser Lys 
145                 150                 155                 160 


Gly Arg Ile Leu Thr Thr Glu Gln Thr Lys Leu Met Ile Ser Gly Ile 
                165                 170                 175     


Thr Gln Ser Leu Asn Ser Gly Phe Ala Gln Thr Leu His Pro Ser Leu 
            180                 185                 190         


Thr Ser Gly Leu Thr Gln Ser Leu Thr Pro Ser Leu Thr Ser Ser Ser 
        195                 200                 205             


Met Thr Ser Gly Leu Ser Ser Gly Met Thr Ser Arg Leu Thr Pro Ser 
    210                 215                 220                 


Val Thr Pro Ala Tyr Thr Pro Gly Phe Pro Ser Gly Leu Val Pro Asn 
225                 230                 235                 240 


Phe Ser Ser Gly Val Glu Pro Asn Ser Leu Gln Thr Leu Lys Leu Met 
                245                 250                 255     


Gln Ile Arg Lys Pro Leu Leu Lys Ser Ser Leu Leu Asp Gln Asn Leu 
            260                 265                 270         


Thr Glu Glu Glu Ile Asn Met Lys Phe Val Gln Asp Leu Leu Asn Trp 
        275                 280                 285             


Val Asp Glu Met Gln Val Gln Leu Asp Arg Thr Glu Trp Gly Ser Asp 
    290                 295                 300                 


Leu Pro Ser Val Glu Ser His Leu Glu Asn His Lys Asn Val His Arg 
305                 310                 315                 320 


Ala Ile Glu Glu Phe Glu Ser Ser Leu Lys Glu Ala Lys Ile Ser Glu 
                325                 330                 335     


Ile Gln Met Thr Ala Pro Leu Lys Leu Thr Tyr Ala Glu Lys Leu His 
            340                 345                 350         


Arg Leu Glu Ser Gln Tyr Ala Lys Leu Leu Asn Thr Ser Arg Asn Gln 
        355                 360                 365             


Glu Arg His Leu Asp Thr Leu His Asn Phe Val Ser Arg Ala Thr Asn 
    370                 375                 380                 


Glu Leu Ile Trp Leu Asn Glu Lys Glu Glu Glu Glu Val Ala Tyr Asp 
385                 390                 395                 400 


Trp Ser Glu Arg Asn Thr Asn Ile Ala Arg Lys Lys Asp Tyr His Ala 
                405                 410                 415     


Glu Leu Met Arg Glu Leu Asp Gln Lys Glu Glu Asn Ile Lys Ser Val 
            420                 425                 430         


Gln Glu Ile Ala Glu Gln Leu Leu Leu Glu Asn His Pro Ala Arg Leu 
        435                 440                 445             


Thr Ile Glu Ala Tyr Arg Ala Ala Met Gln Thr Gln Trp Ser Trp Ile 
    450                 455                 460                 


Leu Gln Leu Cys Gln Cys Val Glu Gln His Ile Lys Glu Asn Thr Ala 
465                 470                 475                 480 


Tyr Phe Glu Phe Phe Asn Asp Ala Lys Glu Ala Thr Asp Tyr Leu Arg 
                485                 490                 495     


Asn Leu Lys Asp Ala Ile Gln Arg Lys Tyr Ser Cys Asp Arg Ser Ser 
            500                 505                 510         


Ser Ile His Lys Leu Glu Asp Leu Val Gln Glu Ser Met Glu Glu Lys 
        515                 520                 525             


Glu Glu Leu Leu Gln Tyr Lys Ser Thr Ile Ala Asn Leu Met Gly Lys 
    530                 535                 540                 


Ala Lys Thr Ile Ile Gln Leu Lys Pro Arg Asn Ser Asp Cys Pro Leu 
545                 550                 555                 560 


Lys Thr Ser Ile Pro Ile Lys Ala Ile Cys Asp Tyr Arg Gln Ile Glu 
                565                 570                 575     


Ile Thr Ile Tyr Lys Asp Asp Glu Cys Val Leu Ala Asn Asn Ser His 
            580                 585                 590         


Arg Ala Lys Trp Lys Val Ile Ser Pro Thr Gly Asn Glu Ala Met Val 
        595                 600                 605             


Pro Ser Val Cys Phe Thr Val Pro Pro Pro Asn Lys Glu Ala Val Asp 
    610                 615                 620                 


Leu Ala Asn Arg Ile Glu Gln Gln Tyr Gln Asn Val Leu Thr Leu Trp 
625                 630                 635                 640 


His Glu Ser His Ile Asn Met Lys Ser Val Val Ser Trp His Tyr Leu 
                645                 650                 655     


Ile Asn Glu Ile Asp Arg Ile Arg Ala Ser Asn Val Ala Ser Ile Lys 
            660                 665                 670         


Thr Met Leu Pro Gly Glu His Gln Gln Val Leu Ser Asn Leu Gln Ser 
        675                 680                 685             


Arg Phe Glu Asp Phe Leu Glu Asp Ser Gln Glu Ser Gln Val Phe Ser 
    690                 695                 700                 


Gly Ser Asp Ile Thr Gln Leu Glu Lys Glu Val Asn Val Cys Lys Gln 
705                 710                 715                 720 


Tyr Tyr Gln Glu Leu Leu Lys Ser Ala Glu Arg Glu Glu Gln Glu Glu 
                725                 730                 735     


Ser Val Tyr Asn Leu Tyr Ile Ser Glu Val Arg Asn Ile Arg Leu Arg 
            740                 745                 750         


Leu Glu Asn Cys Glu Asp Arg Leu Ile Arg Gln Ile Arg Thr Pro Leu 
        755                 760                 765             


Glu Arg Asp Asp Leu His Glu Ser Val Phe Arg Ile Thr Glu Gln Glu 
    770                 775                 780                 


Lys Leu Lys Lys Glu Leu Glu Arg Leu Lys Asp Asp Leu Gly Thr Ile 
785                 790                 795                 800 


Thr Asn Lys Cys Glu Glu Phe Phe Ser Gln Ala Ala Ala Ser Ser Ser 
                805                 810                 815     


Val Pro Thr Leu Arg Ser Glu Leu Asn Val Val Leu Gln Asn Met Asn 
            820                 825                 830         


Gln Val Tyr Ser Met Ser Ser Thr Tyr Ile Asp Lys Leu Lys Thr Val 
        835                 840                 845             


Asn Leu Val Leu Lys Asn Thr Gln Ala Ala Glu Ala Leu Val Lys Leu 
    850                 855                 860                 


Tyr Glu Thr Lys Leu Cys Glu Glu Glu Ala Val Ile Ala Asp Lys Asn 
865                 870                 875                 880 


Asn Ile Glu Asn Leu Ile Ser Thr Leu Lys Gln Trp Arg Ser Glu Val 
                885                 890                 895     


Asp Glu Lys Arg Gln Val Phe His Ala Leu Glu Asp Glu Leu Gln Lys 
            900                 905                 910         


Ala Lys Ala Ile Ser Asp Glu Met Phe Lys Thr Tyr Lys Glu Arg Asp 
        915                 920                 925             


Leu Asp Phe Asp Trp His Lys Glu Lys Ala Asp Gln Leu Val Glu Arg 
    930                 935                 940                 


Trp Gln Asn Val His Val Gln Ile Asp Asn Arg Leu Arg Asp Leu Glu 
945                 950                 955                 960 


Gly Ile Gly Lys Ser Leu Lys Tyr Tyr Arg Asp Thr Tyr His Pro Leu 
                965                 970                 975     


Asp Asp Trp Ile Gln Gln Val Glu Thr Thr Gln Arg Lys Ile Gln Glu 
            980                 985                 990         


Asn Gln Pro Glu Asn Ser Lys Thr  Leu Ala Thr Gln Leu  Asn Gln Gln 
        995                 1000                 1005             


Lys Met  Leu Val Ser Glu Ile  Glu Met Lys Gln Ser  Lys Met Asp 
    1010                 1015                 1020             


Glu Cys  Gln Lys Tyr Ala Glu  Gln Tyr Ser Ala Thr  Val Lys Asp 
    1025                 1030                 1035             


Tyr Glu  Leu Gln Thr Met Thr  Tyr Arg Ala Met Val  Asp Ser Gln 
    1040                 1045                 1050             


Gln Lys  Ser Pro Val Lys Arg  Arg Arg Met Gln Ser  Ser Ala Asp 
    1055                 1060                 1065             


Leu Ile  Ile Gln Glu Phe Met  Asp Leu Arg Thr Arg  Tyr Thr Ala 
    1070                 1075                 1080             


Leu Val  Thr Leu Met Thr Gln  Tyr Ile Lys Phe Ala  Gly Asp Ser 
    1085                 1090                 1095             


Leu Lys  Arg Leu Glu Glu Glu  Glu Lys Ser Leu Glu  Glu Glu Lys 
    1100                 1105                 1110             


Lys Glu  His Val Glu Lys Ala  Lys Glu Leu Gln Lys  Trp Val Ser 
    1115                 1120                 1125             


Asn Ile  Ser Lys Thr Leu Lys  Asp Ala Glu Lys Ala  Gly Lys Pro 
    1130                 1135                 1140             


Pro Phe  Ser Lys Gln Lys Ile  Ser Ser Glu Glu Ile  Ser Thr Lys 
    1145                 1150                 1155             


Lys Glu  Gln Leu Ser Glu Ala  Leu Gln Thr Ile Gln  Leu Phe Leu 
    1160                 1165                 1170             


Ala Lys  His Gly Asp Lys Met  Thr Asp Glu Glu Arg  Asn Glu Leu 
    1175                 1180                 1185             


Glu Lys  Gln Val Lys Thr Leu  Gln Glu Ser Tyr Asn  Leu Leu Phe 
    1190                 1195                 1200             


Ser Glu  Ser Leu Lys Gln Leu  Gln Glu Ser Gln Thr  Ser Gly Asp 
    1205                 1210                 1215             


Val Lys  Val Glu Glu Lys Ile  Val Ala Glu Arg Gln  Gln Glu Tyr 
    1220                 1225                 1230             


Lys Glu  Lys Leu Gln Gly Ile  Cys Asp Leu Leu Thr  Gln Thr Glu 
    1235                 1240                 1245             


Asn Arg  Leu Ile Gly His Gln  Glu Ala Phe Met Ile  Gly Asp Gly 
    1250                 1255                 1260             


Thr Val  Glu Leu Lys Lys Tyr  Gln Ser Lys Gln Glu  Glu Leu Gln 
    1265                 1270                 1275             


Lys Asp  Met Gln Gly Ser Ala  Gln Ala Leu Ala Glu  Val Val Lys 
    1280                 1285                 1290             


Asn Thr  Glu Asn Phe Leu Lys  Glu Asn Gly Glu Lys  Leu Ser Gln 
    1295                 1300                 1305             


Glu Asp  Lys Ala Leu Ile Glu  Gln Lys Leu Asn Glu  Ala Lys Ile 
    1310                 1315                 1320             


Lys Cys  Glu Gln Leu Asn Leu  Lys Ala Glu Gln Ser  Lys Lys Glu 
    1325                 1330                 1335             


Leu Asp  Lys Val Val Thr Thr  Ala Ile Lys Glu Glu  Thr Glu Lys 
    1340                 1345                 1350             


Val Ala  Ala Val Lys Gln Leu  Glu Glu Ser Lys Thr  Lys Ile Glu 
    1355                 1360                 1365             


Asn Leu  Leu Asp Trp Leu Ser  Asn Val Asp Lys Asp  Ser Glu Arg 
    1370                 1375                 1380             


Ala Gly  Thr Lys His Lys Gln  Val Ile Glu Gln Asn  Gly Thr His 
    1385                 1390                 1395             


Phe Gln  Glu Gly Asp Gly Lys  Ser Ala Ile Gly Glu  Glu Asp Glu 
    1400                 1405                 1410             


Val Asn  Gly Asn Leu Leu Glu  Thr Asp Val Asp Gly  Gln Val Gly 
    1415                 1420                 1425             


Thr Thr  Gln Glu Asn Leu Asn  Gln Gln Tyr Gln Lys  Val Lys Ala 
    1430                 1435                 1440             


Gln His  Glu Lys Ile Ile Ser  Gln His Gln Ala Val  Ile Ile Ala 
    1445                 1450                 1455             


Thr Gln  Ser Ala Gln Val Leu  Leu Glu Lys Gln Gly  Gln Tyr Leu 
    1460                 1465                 1470             


Ser Pro  Glu Glu Lys Glu Lys  Leu Gln Lys Asn Met  Lys Glu Leu 
    1475                 1480                 1485             


Lys Val  His Tyr Glu Thr Ala  Leu Ala Glu Ser Glu  Lys Lys Met 
    1490                 1495                 1500             


Lys Leu  Thr His Ser Leu Gln  Glu Glu Leu Glu Lys  Phe Asp Ala 
    1505                 1510                 1515             


Asp Tyr  Thr Glu Phe Glu His  Trp Leu Gln Gln Ser  Glu Gln Glu 
    1520                 1525                 1530             


Leu Glu  Asn Leu Glu Ala Gly  Ala Asp Asp Ile Asn  Gly Leu Met 
    1535                 1540                 1545             


Thr Lys  Leu Lys Arg Gln Lys  Ser Phe Ser Glu Asp  Val Ile Ser 
    1550                 1555                 1560             


His Lys  Gly Asp Leu Arg Tyr  Ile Thr Ile Ser Gly  Asn Arg Val 
    1565                 1570                 1575             


Leu Glu  Ala Ala Lys Ser Cys  Ser Lys Arg Asp Gly  Gly Lys Val 
    1580                 1585                 1590             


Asp Thr  Ser Ala Thr His Arg  Glu Val Gln Arg Lys  Leu Asp His 
    1595                 1600                 1605             


Ala Thr  Asp Arg Phe Arg Ser  Leu Tyr Ser Lys Cys  Asn Val Leu 
    1610                 1615                 1620             


Gly Asn  Asn Leu Lys Asp Leu  Val Asp Lys Tyr Gln  His Tyr Glu 
    1625                 1630                 1635             


Asp Ala  Ser Cys Gly Leu Leu  Ala Gly Leu Gln Ala  Cys Glu Ala 
    1640                 1645                 1650             


Thr Ala  Ser Lys His Leu Ser  Glu Pro Ile Ala Val  Asp Pro Lys 
    1655                 1660                 1665             


Asn Leu  Gln Arg Gln Leu Glu  Glu Thr Lys Ala Leu  Gln Gly Gln 
    1670                 1675                 1680             


Ile Ser  Ser Gln Gln Val Ala  Val Glu Lys Leu Lys  Lys Thr Ala 
    1685                 1690                 1695             


Glu Val  Leu Leu Asp Ala Arg  Gly Ser Leu Leu Pro  Ala Lys Asn 
    1700                 1705                 1710             


Asp Ile  Gln Lys Thr Leu Asp  Asp Ile Val Gly Arg  Tyr Glu Asp 
    1715                 1720                 1725             


Leu Ser  Lys Ser Val Asn Glu  Arg Asn Glu Lys Leu  Gln Ile Thr 
    1730                 1735                 1740             


Leu Thr  Arg Ser Leu Ser Val  Gln Asp Gly Leu Asp  Glu Met Leu 
    1745                 1750                 1755             


Asp Trp  Met Gly Asn Val Glu  Ser Ser Leu Lys Glu  Gln Gly Gln 
    1760                 1765                 1770             


Val Pro  Leu Asn Ser Thr Ala  Leu Gln Asp Ile Ile  Ser Lys Asn 
    1775                 1780                 1785             


Ile Met  Leu Glu Gln Asp Ile  Ala Gly Arg Gln Ser  Ser Ile Asn 
    1790                 1795                 1800             


Ala Met  Asn Glu Lys Val Lys  Lys Phe Met Glu Thr  Thr Asp Pro 
    1805                 1810                 1815             


Ser Thr  Ala Ser Ser Leu Gln  Ala Lys Met Lys Asp  Leu Ser Ala 
    1820                 1825                 1830             


Arg Phe  Ser Glu Ala Ser His  Lys His Lys Glu Thr  Leu Ala Lys 
    1835                 1840                 1845             


Met Glu  Glu Leu Lys Thr Lys  Val Glu Leu Phe Glu  Asn Leu Ser 
    1850                 1855                 1860             


Glu Lys  Leu Gln Thr Phe Leu  Glu Thr Lys Thr Gln  Ala Leu Thr 
    1865                 1870                 1875             


Glu Val  Asp Val Pro Gly Lys  Asp Val Thr Glu Leu  Ser Gln Tyr 
    1880                 1885                 1890             


Met Gln  Glu Ser Thr Ser Glu  Phe Leu Glu His Lys  Lys His Leu 
    1895                 1900                 1905             


Glu Val  Leu His Ser Leu Leu  Lys Glu Ile Ser Ser  His Gly Leu 
    1910                 1915                 1920             


Pro Ser  Asp Lys Ala Leu Val  Leu Glu Lys Thr Asn  Asn Leu Ser 
    1925                 1930                 1935             


Lys Lys  Phe Lys Glu Met Glu  Asp Thr Ile Lys Glu  Lys Lys Glu 
    1940                 1945                 1950             


Ala Val  Thr Ser Cys Gln Glu  Gln Leu Asp Ala Phe  Gln Val Leu 
    1955                 1960                 1965             


Val Lys  Ser Leu Lys Ser Trp  Ile Lys Glu Thr Thr  Lys Lys Val 
    1970                 1975                 1980             


Pro Ile  Val Gln Pro Ser Phe  Gly Ala Glu Asp Leu  Gly Lys Ser 
    1985                 1990                 1995             


Leu Glu  Asp Thr Lys Lys Leu  Gln Glu Lys Trp Ser  Leu Lys Thr 
    2000                 2005                 2010             


Pro Glu  Ile Gln Lys Val Asn  Asn Ser Gly Ile Ser  Leu Cys Asn 
    2015                 2020                 2025             


Leu Ile  Ser Ala Val Thr Thr  Pro Ala Lys Ala Ile  Ala Ala Val 
    2030                 2035                 2040             


Lys Ser  Gly Gly Ala Val Leu  Asn Gly Glu Gly Thr  Ala Thr Asn 
    2045                 2050                 2055             


Thr Glu  Glu Phe Trp Ala Asn  Lys Gly Leu Thr Ser  Ile Lys Lys 
    2060                 2065                 2070             


Asp Met  Thr Asp Ile Ser His  Gly Tyr Glu Asp Leu  Gly Leu Leu 
    2075                 2080                 2085             


Leu Lys  Asp Lys Ile Ala Glu  Leu Asn Thr Lys Leu  Ser Lys Leu 
    2090                 2095                 2100             


Gln Lys  Ala Gln Glu Glu Ser  Ser Ala Met Met Gln  Trp Leu Gln 
    2105                 2110                 2115             


Lys Met  Asn Lys Thr Ala Thr  Lys Trp Gln Gln Thr  Pro Ala Pro 
    2120                 2125                 2130             


Thr Asp  Thr Glu Ala Val Lys  Thr Gln Val Glu Gln  Asn Lys Ser 
    2135                 2140                 2145             


Phe Glu  Ala Glu Leu Lys Gln  Asn Val Asn Lys Val  Gln Glu Leu 
    2150                 2155                 2160             


Lys Asp  Lys Leu Thr Glu Leu  Leu Glu Glu Asn Pro  Asp Thr Pro 
    2165                 2170                 2175             


Glu Ala  Pro Arg Trp Lys Gln  Met Leu Thr Glu Ile  Asp Ser Lys 
    2180                 2185                 2190             


Trp Gln  Glu Leu Asn Gln Leu  Thr Ile Asp Arg Gln  Gln Lys Leu 
    2195                 2200                 2205             


Glu Glu  Ser Ser Asn Asn Leu  Thr Gln Phe Gln Thr  Val Glu Ala 
    2210                 2215                 2220             


Gln Leu  Lys Gln Trp Leu Val  Glu Lys Glu Leu Met  Val Ser Val 
    2225                 2230                 2235             


Leu Gly  Pro Leu Ser Ile Asp  Pro Asn Met Leu Asn  Thr Gln Arg 
    2240                 2245                 2250             


Gln Gln  Val Gln Ile Leu Leu  Gln Glu Phe Ala Thr  Arg Lys Pro 
    2255                 2260                 2265             


Gln Tyr  Glu Gln Leu Thr Ala  Ala Gly Gln Gly Ile  Leu Ser Arg 
    2270                 2275                 2280             


Pro Gly  Glu Asp Pro Ser Leu  Arg Gly Ile Val Lys  Glu Gln Leu 
    2285                 2290                 2295             


Ala Ala  Val Thr Gln Lys Trp  Asp Ser Leu Thr Gly  Gln Leu Ser 
    2300                 2305                 2310             


Asp Arg  Cys Asp Trp Ile Asp  Gln Ala Ile Val Lys  Ser Thr Gln 
    2315                 2320                 2325             


Tyr Gln  Ser Leu Leu Arg Ser  Leu Ser Asp Lys Leu  Ser Asp Leu 
    2330                 2335                 2340             


Asp Asn  Lys Leu Ser Ser Ser  Leu Ala Val Ser Thr  His Pro Asp 
    2345                 2350                 2355             


Ala Met  Asn Gln Gln Leu Glu  Thr Ala Gln Lys Met  Lys Gln Glu 
    2360                 2365                 2370             


Ile Gln  Gln Glu Lys Lys Gln  Ile Lys Val Ala Gln  Ala Leu Cys 
    2375                 2380                 2385             


Glu Asp  Leu Ser Ala Leu Val  Lys Glu Glu Tyr Leu  Lys Ala Glu 
    2390                 2395                 2400             


Leu Ser  Arg Gln Leu Glu Gly  Ile Leu Lys Ser Phe  Lys Asp Val 
    2405                 2410                 2415             


Glu Gln  Lys Ala Glu Asn His  Val Gln His Leu Gln  Ser Ala Cys 
    2420                 2425                 2430             


Ala Ser  Ser His Gln Phe Gln  Gln Met Ser Arg Asp  Phe Gln Ala 
    2435                 2440                 2445             


Trp Leu  Asp Thr Lys Lys Glu  Glu Gln Asn Lys Ser  His Pro Ile 
    2450                 2455                 2460             


Ser Ala  Lys Leu Asp Val Leu  Glu Ser Leu Ile Lys  Asp His Lys 
    2465                 2470                 2475             


Asp Phe  Ser Lys Thr Leu Thr  Ala Gln Ser His Met  Tyr Glu Lys 
    2480                 2485                 2490             


Thr Ile  Ala Glu Gly Glu Asn  Leu Leu Leu Lys Thr  Gln Gly Ser 
    2495                 2500                 2505             


Glu Lys  Ala Ala Leu Gln Leu  Gln Leu Asn Thr Ile  Lys Thr Asn 
    2510                 2515                 2520             


Trp Asp  Thr Phe Asn Lys Gln  Val Lys Glu Arg Glu  Asn Lys Leu 
    2525                 2530                 2535             


Lys Glu  Ser Leu Glu Lys Ala  Leu Lys Tyr Lys Glu  Gln Val Glu 
    2540                 2545                 2550             


Thr Leu  Trp Pro Trp Ile Asp  Lys Cys Gln Asn Asn  Leu Glu Glu 
    2555                 2560                 2565             


Ile Lys  Phe Cys Leu Asp Pro  Ala Glu Gly Glu Asn  Ser Ile Ala 
    2570                 2575                 2580             


Lys Leu  Lys Ser Leu Gln Lys  Glu Met Asp Gln His  Phe Gly Met 
    2585                 2590                 2595             


Val Glu  Leu Leu Asn Asn Thr  Ala Asn Ser Leu Leu  Ser Val Cys 
    2600                 2605                 2610             


Glu Ile  Asp Lys Glu Val Val  Thr Asp Glu Asn Lys  Ser Leu Ile 
    2615                 2620                 2625             


Gln Lys  Val Asp Met Val Thr  Glu Gln Leu His Ser  Lys Lys Phe 
    2630                 2635                 2640             


Cys Leu  Glu Asn Met Thr Gln  Lys Phe Lys Glu Phe  Gln Glu Val 
    2645                 2650                 2655             


Ser Lys  Glu Ser Lys Arg Gln  Leu Gln Cys Ala Lys  Glu Gln Leu 
    2660                 2665                 2670             


Asp Ile  His Asp Ser Leu Gly  Ser Gln Ala Tyr Ser  Asn Lys Tyr 
    2675                 2680                 2685             


Leu Thr  Met Leu Gln Thr Gln  Gln Lys Ser Leu Gln  Ala Leu Lys 
    2690                 2695                 2700             


His Gln  Val Asp Leu Ala Lys  Arg Leu Ala Gln Asp  Leu Val Val 
    2705                 2710                 2715             


Glu Ala  Ser Asp Ser Lys Gly  Thr Ser Asp Val Leu  Leu Gln Val 
    2720                 2725                 2730             


Glu Thr  Ile Ala Gln Glu His  Ser Thr Leu Ser Gln  Gln Val Asp 
    2735                 2740                 2745             


Glu Lys  Cys Ser Phe Leu Glu  Thr Lys Leu Gln Gly  Ile Gly His 
    2750                 2755                 2760             


Phe Gln  Asn Thr Ile Arg Glu  Met Phe Ser Gln Phe  Ala Glu Phe 
    2765                 2770                 2775             


Asp Asp  Glu Leu Asp Ser Met  Ala Pro Val Gly Arg  Asp Ala Glu 
    2780                 2785                 2790             


Thr Leu  Gln Lys Gln Lys Glu  Thr Ile Lys Ala Phe  Leu Lys Lys 
    2795                 2800                 2805             


Leu Glu  Ala Leu Met Ala Ser  Asn Asp Asn Ala Asn  Lys Thr Cys 
    2810                 2815                 2820             


Lys Met  Met Leu Ala Thr Glu  Glu Thr Ser Pro Asp  Leu Val Gly 
    2825                 2830                 2835             


Ile Lys  Arg Asp Leu Glu Ala  Leu Ser Lys Gln Cys  Asn Lys Leu 
    2840                 2845                 2850             


Leu Asp  Arg Ala Gln Ala Arg  Glu Glu Gln Val Glu  Gly Thr Ile 
    2855                 2860                 2865             


Lys Arg  Leu Glu Glu Phe Tyr  Ser Lys Leu Lys Glu  Phe Ser Ile 
    2870                 2875                 2880             


Leu Leu  Gln Lys Ala Glu Glu  His Glu Glu Ser Gln  Gly Pro Val 
    2885                 2890                 2895             


Gly Met  Glu Thr Glu Thr Ile  Asn Gln Gln Leu Asn  Met Phe Lys 
    2900                 2905                 2910             


Val Phe  Gln Lys Glu Glu Ile  Glu Pro Leu Gln Gly  Lys Gln Gln 
    2915                 2920                 2925             


Asp Val  Asn Trp Leu Gly Gln  Gly Leu Ile Gln Ser  Ala Ala Lys 
    2930                 2935                 2940             


Ser Thr  Ser Thr Gln Gly Leu  Glu His Asp Leu Asp  Asp Val Asn 
    2945                 2950                 2955             


Ala Arg  Trp Lys Thr Leu Asn  Lys Lys Val Ala Gln  Arg Ala Ala 
    2960                 2965                 2970             


Gln Leu  Gln Glu Ala Leu Leu  His Cys Gly Arg Phe  Gln Asp Ala 
    2975                 2980                 2985             


Leu Glu  Ser Leu Leu Ser Trp  Met Val Asp Thr Glu  Glu Leu Val 
    2990                 2995                 3000             


Ala Asn  Gln Lys Pro Pro Ser  Ala Glu Phe Lys Val  Val Lys Ala 
    3005                 3010                 3015             


Gln Ile  Gln Glu Gln Lys Leu  Leu Gln Arg Leu Leu  Asp Asp Arg 
    3020                 3025                 3030             


Lys Ser  Thr Val Glu Val Ile  Lys Arg Glu Gly Glu  Lys Ile Ala 
    3035                 3040                 3045             


Thr Thr  Ala Glu Pro Ala Asp  Lys Val Lys Ile Leu  Lys Gln Leu 
    3050                 3055                 3060             


Ser Leu  Leu Asp Ser Arg Trp  Glu Ala Leu Leu Asn  Lys Ala Glu 
    3065                 3070                 3075             


Thr Arg  Asn Arg Gln Leu Glu  Gly Ile Ser Val Val  Ala Gln Gln 
    3080                 3085                 3090             


Phe His  Glu Thr Leu Glu Pro  Leu Asn Glu Trp Leu  Thr Thr Ile 
    3095                 3100                 3105             


Glu Lys  Arg Leu Val Asn Cys  Glu Pro Ile Gly Thr  Gln Ala Ser 
    3110                 3115                 3120             


Lys Leu  Glu Glu Gln Ile Ala  Gln His Lys Ala Leu  Glu Asp Asp 
    3125                 3130                 3135             


Ile Ile  Asn His Asn Lys His  Leu His Gln Ala Val  Ser Ile Gly 
    3140                 3145                 3150             


Gln Ser  Leu Lys Val Leu Ser  Ser Arg Glu Asp Lys  Asp Met Val 
    3155                 3160                 3165             


Gln Ser  Lys Leu Asp Phe Ser  Gln Val Trp Tyr Ile  Glu Ile Gln 
    3170                 3175                 3180             


Glu Lys  Ser His Ser Arg Ser  Glu Leu Leu Gln Gln  Ala Leu Cys 
    3185                 3190                 3195             


Asn Ala  Lys Ile Phe Gly Glu  Asp Glu Val Glu Leu  Met Asn Trp 
    3200                 3205                 3210             


Leu Asn  Glu Val His Asp Lys  Leu Ser Lys Leu Ser  Val Gln Asp 
    3215                 3220                 3225             


Tyr Ser  Thr Glu Gly Leu Trp  Lys Gln Gln Ser Glu  Leu Arg Val 
    3230                 3235                 3240             


Leu Gln  Glu Asp Ile Leu Leu  Arg Lys Gln Asn Val  Asp Gln Ala 
    3245                 3250                 3255             


Leu Leu  Asn Gly Leu Glu Leu  Leu Lys Gln Thr Thr  Gly Asp Glu 
    3260                 3265                 3270             


Val Leu  Ile Ile Gln Asp Lys  Leu Glu Ala Ile Lys  Ala Arg Tyr 
    3275                 3280                 3285             


Lys Asp  Ile Thr Lys Leu Ser  Thr Asp Val Ala Lys  Thr Leu Glu 
    3290                 3295                 3300             


Gln Ala  Leu Gln Leu Ala Arg  Arg Leu His Ser Thr  His Glu Glu 
    3305                 3310                 3315             


Leu Cys  Thr Trp Leu Asp Lys  Val Glu Val Glu Leu  Leu Ser Tyr 
    3320                 3325                 3330             


Glu Thr  Gln Val Leu Lys Gly  Glu Glu Ala Ser Gln  Ala Gln Met 
    3335                 3340                 3345             


Arg Pro  Lys Glu Leu Lys Lys  Glu Ala Lys Asn Asn  Lys Ala Leu 
    3350                 3355                 3360             


Leu Asp  Ser Leu Asn Glu Val  Ser Ser Ala Leu Leu  Glu Leu Val 
    3365                 3370                 3375             


Pro Trp  Arg Ala Arg Glu Gly  Leu Glu Lys Met Val  Ala Glu Asp 
    3380                 3385                 3390             


Asn Glu  Arg Tyr Arg Leu Val  Ser Asp Thr Ile Thr  Gln Lys Val 
    3395                 3400                 3405             


Glu Glu  Ile Asp Ala Ala Ile  Leu Arg Ser Gln Gln  Phe Asp Gln 
    3410                 3415                 3420             


Ala Ala  Asp Ala Glu Leu Ser  Trp Ile Thr Glu Thr  Glu Lys Lys 
    3425                 3430                 3435             


Leu Met  Ser Leu Gly Asp Ile  Arg Leu Glu Gln Asp  Gln Thr Ser 
    3440                 3445                 3450             


Ala Gln  Leu Gln Val Gln Lys  Thr Phe Thr Met Glu  Ile Leu Arg 
    3455                 3460                 3465             


His Lys  Asp Ile Ile Asp Asp  Leu Val Lys Ser Gly  His Lys Ile 
    3470                 3475                 3480             


Met Thr  Ala Cys Ser Glu Glu  Glu Lys Gln Ser Met  Lys Lys Lys 
    3485                 3490                 3495             


Leu Asp  Lys Val Leu Lys Asn  Tyr Asp Thr Ile Cys  Gln Ile Asn 
    3500                 3505                 3510             


Ser Glu  Arg Tyr Leu Gln Leu  Glu Arg Ala Gln Ser  Leu Val Asn 
    3515                 3520                 3525             


Gln Phe  Trp Glu Thr Tyr Glu  Glu Leu Trp Pro Trp  Leu Thr Glu 
    3530                 3535                 3540             


Thr Gln  Ser Ile Ile Ser Gln  Leu Pro Ala Pro Ala  Leu Glu Tyr 
    3545                 3550                 3555             


Glu Thr  Leu Arg Gln Gln Gln  Glu Glu His Arg Gln  Leu Arg Glu 
    3560                 3565                 3570             


Leu Ile  Ala Glu His Lys Pro  His Ile Asp Lys Met  Asn Lys Thr 
    3575                 3580                 3585             


Gly Pro  Gln Leu Leu Glu Leu  Ser Pro Gly Glu Gly  Phe Ser Ile 
    3590                 3595                 3600             


Gln Glu  Lys Tyr Val Ala Ala  Asp Thr Leu Tyr Ser  Gln Ile Lys 
    3605                 3610                 3615             


Glu Asp  Val Lys Lys Arg Ala  Val Ala Leu Asp Glu  Ala Ile Ser 
    3620                 3625                 3630             


Gln Ser  Thr Gln Phe His Asp  Lys Ile Asp Gln Ile  Leu Glu Ser 
    3635                 3640                 3645             


Leu Glu  Arg Ile Val Glu Arg  Leu Arg Gln Pro Pro  Ser Ile Ser 
    3650                 3655                 3660             


Ala Glu  Val Glu Lys Ile Lys  Glu Gln Ile Ser Glu  Asn Lys Asn 
    3665                 3670                 3675             


Val Ser  Val Asp Met Glu Lys  Leu Gln Pro Leu Tyr  Glu Thr Leu 
    3680                 3685                 3690             


Lys Gln  Arg Gly Glu Glu Met  Ile Ala Arg Ser Gly  Gly Thr Asp 
    3695                 3700                 3705             


Lys Asp  Ile Ser Ala Lys Ala  Val Gln Asp Lys Leu  Asp Gln Met 
    3710                 3715                 3720             


Val Phe  Ile Trp Glu Asn Ile  His Thr Leu Val Glu  Glu Arg Glu 
    3725                 3730                 3735             


Ala Lys  Leu Leu Asp Val Met  Glu Leu Ala Glu Lys  Phe Trp Cys 
    3740                 3745                 3750             


Asp His  Met Ser Leu Ile Val  Thr Ile Lys Asp Thr  Gln Asp Phe 
    3755                 3760                 3765             


Ile Arg  Asp Leu Glu Asp Pro  Gly Ile Asp Pro Ser  Val Val Lys 
    3770                 3775                 3780             


Gln Gln  Gln Glu Ala Ala Glu  Thr Ile Arg Glu Glu  Ile Asp Gly 
    3785                 3790                 3795             


Leu Gln  Glu Glu Leu Asp Ile  Val Ile Asn Leu Gly  Ser Glu Leu 
    3800                 3805                 3810             


Ile Ala  Ala Cys Gly Glu Pro  Asp Lys Pro Ile Val  Lys Lys Ser 
    3815                 3820                 3825             


Ile Asp  Glu Leu Asn Ser Ala  Trp Asp Ser Leu Asn  Lys Ala Trp 
    3830                 3835                 3840             


Lys Asp  Arg Ile Asp Lys Leu  Glu Glu Ala Met Gln  Ala Ala Val 
    3845                 3850                 3855             


Gln Tyr  Gln Asp Gly Leu Gln  Ala Val Phe Asp Trp  Val Asp Ile 
    3860                 3865                 3870             


Ala Gly  Gly Lys Leu Ala Ser  Met Ser Pro Ile Gly  Thr Asp Leu 
    3875                 3880                 3885             


Glu Thr  Val Lys Gln Gln Ile  Glu Glu Leu Lys Gln  Phe Lys Ser 
    3890                 3895                 3900             


Glu Ala  Tyr Gln Gln Gln Ile  Glu Met Glu Arg Leu  Asn His Gln 
    3905                 3910                 3915             


Ala Glu  Leu Leu Leu Lys Lys  Val Thr Glu Glu Ser  Asp Lys His 
    3920                 3925                 3930             


Thr Val  Gln Asp Pro Leu Met  Glu Leu Lys Leu Ile  Trp Asp Ser 
    3935                 3940                 3945             


Leu Glu  Glu Arg Ile Ile Asn  Arg Gln His Lys Leu  Glu Gly Ala 
    3950                 3955                 3960             


Leu Leu  Ala Leu Gly Gln Phe  Gln His Ala Leu Asp  Glu Leu Leu 
    3965                 3970                 3975             


Ala Trp  Leu Thr His Thr Glu  Gly Leu Leu Ser Glu  Gln Lys Pro 
    3980                 3985                 3990             


Val Gly  Gly Asp Pro Lys Ala  Ile Glu Ile Glu Leu  Ala Lys His 
    3995                 4000                 4005             


His Val  Leu Gln Asn Asp Val  Leu Ala His Gln Ser  Thr Val Glu 
    4010                 4015                 4020             


Ala Val  Asn Lys Ala Gly Asn  Asp Leu Ile Glu Ser  Ser Ala Gly 
    4025                 4030                 4035             


Glu Glu  Ala Ser Asn Leu Gln  Asn Lys Leu Glu Val  Leu Asn Gln 
    4040                 4045                 4050             


Arg Trp  Gln Asn Val Leu Glu  Lys Thr Glu Gln Arg  Lys Gln Gln 
    4055                 4060                 4065             


Leu Asp  Gly Ala Leu Arg Gln  Ala Lys Gly Phe His  Gly Glu Ile 
    4070                 4075                 4080             


Glu Asp  Leu Gln Gln Trp Leu  Thr Asp Thr Glu Arg  His Leu Leu 
    4085                 4090                 4095             


Ala Ser  Lys Pro Leu Gly Gly  Leu Pro Glu Thr Ala  Lys Glu Gln 
    4100                 4105                 4110             


Leu Asn  Val His Met Glu Val  Cys Ala Ala Phe Glu  Ala Lys Glu 
    4115                 4120                 4125             


Glu Thr  Tyr Lys Ser Leu Met  Gln Lys Gly Gln Gln  Met Leu Ala 
    4130                 4135                 4140             


Arg Cys  Pro Lys Ser Ala Glu  Thr Asn Ile Asp Gln  Asp Ile Asn 
    4145                 4150                 4155             


Asn Leu  Lys Glu Lys Trp Glu  Ser Val Glu Thr Lys  Leu Asn Glu 
    4160                 4165                 4170             


Arg Lys  Thr Lys Leu Glu Glu  Ala Leu Asn Leu Ala  Met Glu Phe 
    4175                 4180                 4185             


His Asn  Ser Leu Gln Asp Phe  Ile Asn Trp Leu Thr  Gln Ala Glu 
    4190                 4195                 4200             


Gln Thr  Leu Asn Val Ala Ser  Arg Pro Ser Leu Ile  Leu Asp Thr 
    4205                 4210                 4215             


Val Leu  Phe Gln Ile Asp Glu  His Lys Val Phe Ala  Asn Glu Val 
    4220                 4225                 4230             


Asn Ser  His Arg Glu Gln Ile  Ile Glu Leu Asp Lys  Thr Gly Thr 
    4235                 4240                 4245             


His Leu  Lys Tyr Phe Ser Gln  Lys Gln Asp Val Val  Leu Ile Lys 
    4250                 4255                 4260             


Asn Leu  Leu Ile Ser Val Gln  Ser Arg Trp Glu Lys  Val Val Gln 
    4265                 4270                 4275             


Arg Leu  Val Glu Arg Gly Arg  Ser Leu Asp Asp Ala  Arg Lys Arg 
    4280                 4285                 4290             


Ala Lys  Gln Phe His Glu Ala  Trp Ser Lys Leu Met  Glu Trp Leu 
    4295                 4300                 4305             


Glu Glu  Ser Glu Lys Ser Leu  Asp Ser Glu Leu Glu  Ile Ala Asn 
    4310                 4315                 4320             


Asp Pro  Asp Lys Ile Lys Thr  Gln Leu Ala Gln His  Lys Glu Phe 
    4325                 4330                 4335             


Gln Lys  Ser Leu Gly Ala Lys  His Ser Val Tyr Asp  Thr Thr Asn 
    4340                 4345                 4350             


Arg Thr  Gly Arg Ser Leu Lys  Glu Lys Thr Ser Leu  Ala Asp Asp 
    4355                 4360                 4365             


Asn Leu  Lys Leu Asp Asp Met  Leu Ser Glu Leu Arg  Asp Lys Trp 
    4370                 4375                 4380             


Asp Thr  Ile Cys Gly Lys Ser  Val Glu Arg Gln Asn  Lys Leu Glu 
    4385                 4390                 4395             


Glu Ala  Leu Leu Phe Ser Gly  Gln Phe Thr Asp Ala  Leu Gln Ala 
    4400                 4405                 4410             


Leu Ile  Asp Trp Leu Tyr Arg  Val Glu Pro Gln Leu  Ala Glu Asp 
    4415                 4420                 4425             


Gln Pro  Val His Gly Asp Ile  Asp Leu Val Met Asn  Leu Ile Asp 
    4430                 4435                 4440             


Asn His  Lys Ala Phe Gln Lys  Glu Leu Gly Lys Arg  Thr Ser Ser 
    4445                 4450                 4455             


Val Gln  Ala Leu Lys Arg Ser  Ala Arg Glu Leu Ile  Glu Gly Ser 
    4460                 4465                 4470             


Arg Asp  Asp Ser Ser Trp Val  Lys Val Gln Met Gln  Glu Leu Ser 
    4475                 4480                 4485             


Thr Arg  Trp Glu Thr Val Cys  Ala Leu Ser Ile Ser  Lys Gln Thr 
    4490                 4495                 4500             


Arg Leu  Glu Ala Ala Leu Arg  Gln Ala Glu Glu Phe  His Ser Val 
    4505                 4510                 4515             


Val His  Ala Leu Leu Glu Trp  Leu Ala Glu Ala Glu  Gln Thr Leu 
    4520                 4525                 4530             


Arg Phe  His Gly Val Leu Pro  Asp Asp Glu Asp Ala  Leu Arg Thr 
    4535                 4540                 4545             


Leu Ile  Asp Gln His Lys Glu  Phe Met Lys Lys Leu  Glu Glu Lys 
    4550                 4555                 4560             


Arg Ala  Glu Leu Asn Lys Ala  Thr Thr Met Gly Asp  Thr Val Leu 
    4565                 4570                 4575             


Ala Ile  Cys His Pro Asp Ser  Ile Thr Thr Ile Lys  His Trp Ile 
    4580                 4585                 4590             


Thr Ile  Ile Arg Ala Arg Phe  Glu Glu Val Leu Ala  Trp Ala Lys 
    4595                 4600                 4605             


Gln His  Gln Gln Arg Leu Ala  Ser Ala Leu Ala Gly  Leu Ile Ala 
    4610                 4615                 4620             


Lys Gln  Glu Leu Leu Glu Ala  Leu Leu Ala Trp Leu  Gln Trp Ala 
    4625                 4630                 4635             


Glu Thr  Thr Leu Thr Asp Lys  Asp Lys Glu Val Ile  Pro Gln Glu 
    4640                 4645                 4650             


Ile Glu  Glu Val Lys Ala Leu  Ile Ala Glu His Gln  Thr Phe Met 
    4655                 4660                 4665             


Glu Glu  Met Thr Arg Lys Gln  Pro Asp Val Asp Lys  Val Thr Lys 
    4670                 4675                 4680             


Thr Tyr  Lys Arg Arg Ala Ala  Asp Pro Ser Ser Leu  Gln Ser His 
    4685                 4690                 4695             


Ile Pro  Val Leu Asp Lys Gly  Arg Ala Gly Arg Lys  Arg Phe Pro 
    4700                 4705                 4710             


Ala Ser  Ser Leu Tyr Pro Ser  Gly Ser Gln Thr Gln  Ile Glu Thr 
    4715                 4720                 4725             


Lys Asn  Pro Arg Val Asn Leu  Leu Val Ser Lys Trp  Gln Gln Val 
    4730                 4735                 4740             


Trp Leu  Leu Ala Leu Glu Arg  Arg Arg Lys Leu Asn  Asp Ala Leu 
    4745                 4750                 4755             


Asp Arg  Leu Glu Glu Leu Arg  Glu Phe Ala Asn Phe  Asp Phe Asp 
    4760                 4765                 4770             


Ile Trp  Arg Lys Lys Tyr Met  Arg Trp Met Asn His  Lys Lys Ser 
    4775                 4780                 4785             


Arg Val  Met Asp Phe Phe Arg  Arg Ile Asp Lys Asp  Gln Asp Gly 
    4790                 4795                 4800             


Lys Ile  Thr Arg Gln Glu Phe  Ile Asp Gly Ile Leu  Ser Ser Lys 
    4805                 4810                 4815             


Phe Pro  Thr Ser Arg Leu Glu  Met Ser Ala Val Ala  Asp Ile Phe 
    4820                 4825                 4830             


Asp Arg  Asp Gly Asp Gly Tyr  Ile Asp Tyr Tyr Glu  Phe Val Ala 
    4835                 4840                 4845             


Ala Leu  His Pro Asn Lys Asp  Ala Tyr Lys Pro Ile  Thr Asp Ala 
    4850                 4855                 4860             


Asp Lys  Ile Glu Asp Glu Val  Thr Arg Gln Val Ala  Lys Cys Lys 
    4865                 4870                 4875             


Cys Ala  Lys Arg Phe Gln Val  Glu Gln Ile Gly Asp  Asn Lys Tyr 
    4880                 4885                 4890             


Arg Phe  Phe Leu Gly Asn Gln  Phe Gly Asp Ser Gln  Gln Leu Arg 
    4895                 4900                 4905             


Leu Val  Arg Ile Leu Arg Ser  Thr Val Met Val Arg  Val Gly Gly 
    4910                 4915                 4920             


Gly Trp  Met Ala Leu Asp Glu  Phe Leu Val Lys Asn  Asp Pro Cys 
    4925                 4930                 4935             


Arg Ala  Lys Gly Arg Thr Asn  Met Glu Leu Arg Glu  Lys Phe Ile 
    4940                 4945                 4950             


Leu Ala  Asp Gly Ala Ser Gln  Gly Met Ala Ala Phe  Arg Pro Arg 
    4955                 4960                 4965             


Gly Arg  Arg Ser Arg Pro Ser  Ser Arg Gly Ala Ser  Pro Asn Arg 
    4970                 4975                 4980             


Ser Thr  Ser Val Ser Ser Gln  Ala Ala Gln Ala Ala  Ser Pro Gln 
    4985                 4990                 4995             


Val Pro  Ala Thr Thr Thr Pro  Lys Ile Leu His Pro  Leu Thr Arg 
    5000                 5005                 5010             


Asn Tyr  Gly Lys Pro Trp Leu  Thr Asn Ser Lys Met  Ser Thr Pro 
    5015                 5020                 5025             


Cys Lys  Ala Ala Glu Cys Ser  Asp Phe Pro Val Pro  Ser Ala Glu 
    5030                 5035                 5040             


Gly Thr  Pro Ile Gln Gly Ser  Lys Leu Arg Leu Pro  Gly Tyr Leu 
    5045                 5050                 5055             


Ser Gly  Lys Gly Phe His Ser  Gly Glu Asp Ser Gly  Leu Ile Thr 
    5060                 5065                 5070             


Thr Ala  Ala Ala Arg Val Arg  Thr Gln Phe Ala Asp  Ser Lys Lys 
    5075                 5080                 5085             


Thr Pro  Ser Arg Pro Gly Ser  Arg Ala Gly Ser Lys  Ala Gly Ser 
    5090                 5095                 5100             


Arg Ala  Ser Ser Arg Arg Gly  Ser Asp Ala Ser Asp  Phe Asp Ile 
    5105                 5110                 5115             


Ser Glu  Ile Gln Ser Val Cys  Ser Asp Val Glu Thr  Val Pro Gln 
    5120                 5125                 5130             


Thr His  Arg Pro Thr Pro Arg  Ala Gly Ser Arg Pro  Ser Thr Ala 
    5135                 5140                 5145             


Lys Pro  Ser Lys Ile Pro Thr  Pro Gln Arg Lys Ser  Pro Ala Ser 
    5150                 5155                 5160             


Lys Leu  Asp Lys Ser Ser Lys  Arg 
    5165                 5170     


<210>  4457
<211>  2649
<212>  PRT
<213>  Homo Sapiens

<400>  4457

Met His Ser Ser Ser Tyr Ser Tyr Arg Ser Ser Asp Ser Val Phe Ser 
1               5                   10                  15      


Asn Thr Thr Ser Thr Arg Thr Ser Leu Asp Ser Asn Glu Asn Leu Leu 
            20                  25                  30          


Leu Val His Cys Gly Pro Thr Leu Ile Asn Ser Cys Ile Ser Phe Gly 
        35                  40                  45              


Ser Glu Ser Phe Asp Gly His Arg Leu Glu Met Leu Gln Gln Ile Ala 
    50                  55                  60                  


Asn Arg Val Gln Arg Asp Ser Val Ile Cys Glu Asp Lys Leu Ile Leu 
65                  70                  75                  80  


Ala Gly Asn Ala Leu Gln Ser Asp Ser Lys Arg Leu Glu Ser Gly Val 
                85                  90                  95      


Gln Phe Gln Asn Glu Ala Glu Ile Ala Gly Tyr Ile Leu Glu Cys Glu 
            100                 105                 110         


Asn Leu Leu Arg Gln His Val Ile Asp Val Gln Ile Leu Ile Asp Gly 
        115                 120                 125             


Lys Tyr Tyr Gln Ala Asp Gln Leu Val Gln Arg Val Ala Lys Leu Arg 
    130                 135                 140                 


Asp Glu Ile Met Ala Leu Arg Asn Glu Cys Ser Ser Val Tyr Ser Lys 
145                 150                 155                 160 


Gly Arg Ile Leu Thr Thr Glu Gln Thr Lys Leu Met Ile Ser Gly Ile 
                165                 170                 175     


Thr Gln Ser Leu Asn Ser Gly Phe Ala Gln Thr Leu His Pro Ser Leu 
            180                 185                 190         


Thr Ser Gly Leu Thr Gln Ser Leu Thr Pro Ser Leu Thr Ser Ser Ser 
        195                 200                 205             


Met Thr Ser Gly Leu Ser Ser Gly Met Thr Ser Arg Leu Thr Pro Ser 
    210                 215                 220                 


Val Thr Pro Ala Tyr Thr Pro Gly Phe Pro Ser Gly Leu Val Pro Asn 
225                 230                 235                 240 


Phe Ser Ser Gly Val Glu Pro Asn Ser Leu Gln Thr Leu Lys Leu Met 
                245                 250                 255     


Gln Ile Arg Lys Pro Leu Leu Lys Ser Ser Leu Leu Asp Gln Asn Leu 
            260                 265                 270         


Thr Glu Glu Glu Ile Asn Met Lys Phe Val Gln Asp Leu Leu Asn Trp 
        275                 280                 285             


Val Asp Glu Met Gln Val Gln Leu Asp Arg Thr Glu Trp Gly Ser Asp 
    290                 295                 300                 


Leu Pro Ser Val Glu Ser His Leu Glu Asn His Lys Asn Val His Arg 
305                 310                 315                 320 


Ala Ile Glu Glu Phe Glu Ser Ser Leu Lys Glu Ala Lys Ile Ser Glu 
                325                 330                 335     


Ile Gln Met Thr Ala Pro Leu Lys Leu Thr Tyr Ala Glu Lys Leu His 
            340                 345                 350         


Arg Leu Glu Ser Gln Tyr Ala Lys Leu Leu Asn Thr Ser Arg Asn Gln 
        355                 360                 365             


Glu Arg His Leu Asp Thr Leu His Asn Phe Val Ser Arg Ala Thr Asn 
    370                 375                 380                 


Glu Leu Ile Trp Leu Asn Glu Lys Glu Glu Glu Glu Val Ala Tyr Asp 
385                 390                 395                 400 


Trp Ser Glu Arg Asn Thr Asn Ile Ala Arg Lys Lys Asp Tyr His Ala 
                405                 410                 415     


Glu Leu Met Arg Glu Leu Asp Gln Lys Glu Glu Asn Ile Lys Ser Val 
            420                 425                 430         


Gln Glu Ile Ala Glu Gln Leu Leu Leu Glu Asn His Pro Ala Arg Leu 
        435                 440                 445             


Thr Ile Glu Ala Tyr Arg Ala Ala Met Gln Thr Gln Trp Ser Trp Ile 
    450                 455                 460                 


Leu Gln Leu Cys Gln Cys Val Glu Gln His Ile Lys Glu Asn Thr Ala 
465                 470                 475                 480 


Tyr Phe Glu Phe Phe Asn Asp Ala Lys Glu Ala Thr Asp Tyr Leu Arg 
                485                 490                 495     


Asn Leu Lys Asp Ala Ile Gln Arg Lys Tyr Ser Cys Asp Arg Ser Ser 
            500                 505                 510         


Ser Ile His Lys Leu Glu Asp Leu Val Gln Glu Ser Met Glu Glu Lys 
        515                 520                 525             


Glu Glu Leu Leu Gln Tyr Lys Ser Thr Ile Ala Asn Leu Met Gly Lys 
    530                 535                 540                 


Ala Lys Thr Ile Ile Gln Leu Lys Pro Arg Asn Ser Asp Cys Pro Leu 
545                 550                 555                 560 


Lys Thr Ser Ile Pro Ile Lys Ala Ile Cys Asp Tyr Arg Gln Ile Glu 
                565                 570                 575     


Ile Thr Ile Tyr Lys Asp Asp Glu Cys Val Leu Ala Asn Asn Ser His 
            580                 585                 590         


Arg Ala Lys Trp Lys Val Ile Ser Pro Thr Gly Asn Glu Ala Met Val 
        595                 600                 605             


Pro Ser Val Cys Phe Thr Val Pro Pro Pro Asn Lys Glu Ala Val Asp 
    610                 615                 620                 


Leu Ala Asn Arg Ile Glu Gln Gln Tyr Gln Asn Val Leu Thr Leu Trp 
625                 630                 635                 640 


His Glu Ser His Ile Asn Met Lys Ser Val Val Ser Trp His Tyr Leu 
                645                 650                 655     


Ile Asn Glu Ile Asp Arg Ile Arg Ala Ser Asn Val Ala Ser Ile Lys 
            660                 665                 670         


Thr Met Leu Pro Gly Glu His Gln Gln Val Leu Ser Asn Leu Gln Ser 
        675                 680                 685             


Arg Phe Glu Asp Phe Leu Glu Asp Ser Gln Glu Ser Gln Val Phe Ser 
    690                 695                 700                 


Gly Ser Asp Ile Thr Gln Leu Glu Lys Glu Val Asn Val Cys Lys Gln 
705                 710                 715                 720 


Tyr Tyr Gln Glu Leu Leu Lys Ser Ala Glu Arg Glu Glu Gln Glu Glu 
                725                 730                 735     


Ser Val Tyr Asn Leu Tyr Ile Ser Glu Val Arg Asn Ile Arg Leu Arg 
            740                 745                 750         


Leu Glu Asn Cys Glu Asp Arg Leu Ile Arg Gln Ile Arg Thr Pro Leu 
        755                 760                 765             


Glu Arg Asp Asp Leu His Glu Ser Val Phe Arg Ile Thr Glu Gln Glu 
    770                 775                 780                 


Lys Leu Lys Lys Glu Leu Glu Arg Leu Lys Asp Asp Leu Gly Thr Ile 
785                 790                 795                 800 


Thr Asn Lys Cys Glu Glu Phe Phe Ser Gln Ala Ala Ala Ser Ser Ser 
                805                 810                 815     


Val Pro Thr Leu Arg Ser Glu Leu Asn Val Val Leu Gln Asn Met Asn 
            820                 825                 830         


Gln Val Tyr Ser Met Ser Ser Thr Tyr Ile Asp Lys Leu Lys Thr Val 
        835                 840                 845             


Asn Leu Val Leu Lys Asn Thr Gln Ala Ala Glu Ala Leu Val Lys Leu 
    850                 855                 860                 


Tyr Glu Thr Lys Leu Cys Glu Glu Glu Ala Val Ile Ala Asp Lys Asn 
865                 870                 875                 880 


Asn Ile Glu Asn Leu Ile Ser Thr Leu Lys Gln Trp Arg Ser Glu Val 
                885                 890                 895     


Asp Glu Lys Arg Gln Val Phe His Ala Leu Glu Asp Glu Leu Gln Lys 
            900                 905                 910         


Ala Lys Ala Ile Ser Asp Glu Met Phe Lys Thr Tyr Lys Glu Arg Asp 
        915                 920                 925             


Leu Asp Phe Asp Trp His Lys Glu Lys Ala Asp Gln Leu Val Glu Arg 
    930                 935                 940                 


Trp Gln Asn Val His Val Gln Ile Asp Asn Arg Leu Arg Asp Leu Glu 
945                 950                 955                 960 


Gly Ile Gly Lys Ser Leu Lys Tyr Tyr Arg Asp Thr Tyr His Pro Leu 
                965                 970                 975     


Asp Asp Trp Ile Gln Gln Val Glu Thr Thr Gln Arg Lys Ile Gln Glu 
            980                 985                 990         


Asn Gln Pro Glu Asn Ser Lys Thr  Leu Ala Thr Gln Leu  Asn Gln Gln 
        995                 1000                 1005             


Lys Met  Leu Val Ser Glu Ile  Glu Met Lys Gln Ser  Lys Met Asp 
    1010                 1015                 1020             


Glu Cys  Gln Lys Tyr Ala Glu  Gln Tyr Ser Ala Thr  Val Lys Asp 
    1025                 1030                 1035             


Tyr Glu  Leu Gln Thr Met Thr  Tyr Arg Ala Met Val  Asp Ser Gln 
    1040                 1045                 1050             


Gln Lys  Ser Pro Val Lys Arg  Arg Arg Met Gln Ser  Ser Ala Asp 
    1055                 1060                 1065             


Leu Ile  Ile Gln Glu Phe Met  Asp Leu Arg Thr Arg  Tyr Thr Ala 
    1070                 1075                 1080             


Leu Val  Thr Leu Met Thr Gln  Tyr Ile Lys Phe Ala  Gly Asp Ser 
    1085                 1090                 1095             


Leu Lys  Arg Leu Glu Glu Glu  Glu Ile Lys Arg Cys  Lys Glu Thr 
    1100                 1105                 1110             


Ser Glu  His Gly Ala Tyr Ser  Asp Leu Leu Gln Arg  Gln Lys Ala 
    1115                 1120                 1125             


Thr Val  Leu Glu Asn Ser Lys  Leu Thr Gly Lys Ile  Ser Glu Leu 
    1130                 1135                 1140             


Glu Arg  Met Val Ala Glu Leu  Lys Lys Gln Lys Ser  Arg Val Glu 
    1145                 1150                 1155             


Glu Glu  Leu Pro Lys Val Arg  Glu Ala Ala Glu Asn  Glu Leu Arg 
    1160                 1165                 1170             


Lys Gln  Gln Arg Asn Val Glu  Asp Ile Ser Leu Gln  Lys Ile Arg 
    1175                 1180                 1185             


Ala Glu  Ser Glu Ala Lys Gln  Tyr Arg Arg Glu Leu  Glu Thr Ile 
    1190                 1195                 1200             


Val Arg  Glu Lys Glu Ala Ala  Glu Arg Glu Leu Glu  Arg Val Arg 
    1205                 1210                 1215             


Gln Leu  Thr Ile Glu Ala Glu  Ala Lys Arg Ala Ala  Val Glu Glu 
    1220                 1225                 1230             


Asn Leu  Leu Asn Phe Arg Asn  Gln Leu Glu Glu Asn  Thr Phe Thr 
    1235                 1240                 1245             


Arg Arg  Thr Leu Glu Asp His  Leu Lys Arg Lys Asp  Leu Ser Leu 
    1250                 1255                 1260             


Asn Asp  Leu Glu Gln Gln Lys  Asn Lys Leu Met Glu  Glu Leu Arg 
    1265                 1270                 1275             


Arg Lys  Arg Asp Asn Glu Glu  Glu Leu Leu Lys Leu  Ile Lys Gln 
    1280                 1285                 1290             


Met Glu  Lys Asp Leu Ala Phe  Gln Lys Gln Val Ala  Glu Lys Gln 
    1295                 1300                 1305             


Leu Lys  Glu Lys Gln Lys Ile  Glu Leu Glu Ala Arg  Arg Lys Ile 
    1310                 1315                 1320             


Thr Glu  Ile Gln Tyr Thr Cys  Arg Glu Asn Ala Leu  Pro Val Cys 
    1325                 1330                 1335             


Pro Ile  Thr Gln Ala Thr Ser  Cys Arg Ala Val Thr  Gly Leu Gln 
    1340                 1345                 1350             


Gln Glu  His Asp Lys Gln Lys  Ala Glu Glu Leu Lys  Gln Gln Val 
    1355                 1360                 1365             


Asp Glu  Leu Thr Ala Ala Asn  Arg Lys Ala Glu Gln  Asp Met Arg 
    1370                 1375                 1380             


Glu Leu  Thr Tyr Glu Leu Asn  Ala Leu Gln Leu Glu  Lys Thr Ser 
    1385                 1390                 1395             


Ser Glu  Glu Lys Ala Arg Leu  Leu Lys Asp Lys Leu  Asp Glu Thr 
    1400                 1405                 1410             


Asn Asn  Thr Leu Arg Cys Leu  Lys Leu Glu Leu Glu  Arg Lys Asp 
    1415                 1420                 1425             


Gln Ala  Glu Lys Gly Tyr Ser  Gln Gln Leu Arg Glu  Leu Gly Arg 
    1430                 1435                 1440             


Gln Leu  Asn Gln Thr Thr Gly  Lys Ala Glu Glu Ala  Met Gln Glu 
    1445                 1450                 1455             


Ala Ser  Asp Leu Lys Lys Ile  Lys Arg Asn Tyr Gln  Leu Glu Leu 
    1460                 1465                 1470             


Glu Ser  Leu Asn His Glu Lys  Gly Lys Leu Gln Arg  Glu Val Asp 
    1475                 1480                 1485             


Arg Ile  Thr Arg Ala His Ala  Val Ala Glu Lys Asn  Ile Gln His 
    1490                 1495                 1500             


Leu Asn  Ser Gln Ile His Ser  Phe Arg Asp Glu Lys  Glu Leu Glu 
    1505                 1510                 1515             


Arg Leu  Gln Ile Cys Gln Arg  Lys Ser Asp His Leu  Lys Glu Gln 
    1520                 1525                 1530             


Phe Glu  Lys Ser His Glu Gln  Leu Leu Gln Asn Ile  Lys Ala Glu 
    1535                 1540                 1545             


Lys Glu  Asn Asn Asp Lys Ile  Gln Arg Leu Asn Glu  Glu Leu Glu 
    1550                 1555                 1560             


Lys Ser  Asn Glu Cys Ala Glu  Met Leu Lys Gln Lys  Val Glu Glu 
    1565                 1570                 1575             


Leu Thr  Arg Gln Asn Asn Glu  Thr Lys Leu Met Met  Gln Arg Ile 
    1580                 1585                 1590             


Gln Ala  Glu Ser Glu Asn Ile  Val Leu Glu Lys Gln  Thr Ile Gln 
    1595                 1600                 1605             


Gln Arg  Cys Glu Ala Leu Lys  Ile Gln Ala Asp Gly  Phe Lys Asp 
    1610                 1615                 1620             


Gln Leu  Arg Ser Thr Asn Glu  His Leu His Lys Gln  Thr Lys Thr 
    1625                 1630                 1635             


Glu Gln  Asp Phe Gln Arg Lys  Ile Lys Cys Leu Glu  Glu Asp Leu 
    1640                 1645                 1650             


Ala Lys  Ser Gln Asn Leu Val  Ser Glu Phe Lys Gln  Lys Cys Asp 
    1655                 1660                 1665             


Gln Gln  Asn Ile Ile Ile Gln  Asn Thr Lys Lys Glu  Val Arg Asn 
    1670                 1675                 1680             


Leu Asn  Ala Glu Leu Asn Ala  Ser Lys Glu Glu Lys  Arg Arg Gly 
    1685                 1690                 1695             


Glu Gln  Lys Val Gln Leu Gln  Gln Ala Gln Val Gln  Glu Leu Asn 
    1700                 1705                 1710             


Asn Arg  Leu Lys Lys Val Gln  Asp Glu Leu His Leu  Lys Thr Ile 
    1715                 1720                 1725             


Glu Glu  Gln Met Thr His Arg  Lys Met Val Leu Phe  Gln Glu Glu 
    1730                 1735                 1740             


Ser Gly  Lys Phe Lys Gln Ser  Ala Glu Glu Phe Arg  Lys Lys Met 
    1745                 1750                 1755             


Glu Lys  Leu Met Glu Ser Lys  Val Ile Thr Glu Asn  Asp Ile Ser 
    1760                 1765                 1770             


Gly Ile  Arg Leu Asp Phe Val  Ser Leu Gln Gln Glu  Asn Ser Arg 
    1775                 1780                 1785             


Ala Gln  Glu Asn Ala Lys Leu  Cys Glu Thr Asn Ile  Lys Glu Leu 
    1790                 1795                 1800             


Glu Arg  Gln Leu Gln Gln Tyr  Arg Glu Gln Met Gln  Gln Gly Gln 
    1805                 1810                 1815             


His Met  Glu Ala Asn His Tyr  Gln Lys Cys Gln Lys  Leu Glu Asp 
    1820                 1825                 1830             


Glu Leu  Ile Ala Gln Lys Arg  Glu Val Glu Asn Leu  Lys Gln Lys 
    1835                 1840                 1845             


Met Asp  Gln Gln Ile Lys Glu  His Glu His Gln Leu  Val Leu Leu 
    1850                 1855                 1860             


Gln Cys  Glu Ile Gln Lys Lys  Ser Thr Ala Lys Asp  Cys Thr Phe 
    1865                 1870                 1875             


Lys Pro  Asp Phe Glu Met Thr  Val Lys Glu Cys Gln  His Ser Gly 
    1880                 1885                 1890             


Glu Leu  Ser Ser Arg Asn Thr  Gly His Leu His Pro  Thr Pro Arg 
    1895                 1900                 1905             


Ser Pro  Leu Leu Arg Trp Thr  Gln Glu Pro Gln Pro  Leu Glu Glu 
    1910                 1915                 1920             


Lys Trp  Gln His Arg Val Val  Glu Gln Ile Pro Lys  Glu Val Gln 
    1925                 1930                 1935             


Phe Gln  Pro Pro Gly Ala Pro  Leu Glu Lys Glu Lys  Ser Gln Gln 
    1940                 1945                 1950             


Cys Tyr  Ser Glu Tyr Phe Ser  Gln Thr Ser Thr Glu  Leu Gln Ile 
    1955                 1960                 1965             


Thr Phe  Asp Glu Thr Asn Pro  Ile Thr Arg Leu Ser  Glu Ile Glu 
    1970                 1975                 1980             


Lys Ile  Arg Asp Gln Ala Leu  Asn Asn Ser Arg Pro  Pro Val Arg 
    1985                 1990                 1995             


Tyr Gln  Asp Asn Ala Cys Glu  Met Glu Leu Val Lys  Val Leu Thr 
    2000                 2005                 2010             


Pro Leu  Glu Ile Ala Lys Asn  Lys Gln Tyr Asp Met  His Thr Glu 
    2015                 2020                 2025             


Val Thr  Thr Leu Lys Gln Glu  Lys Asn Pro Val Pro  Ser Ala Glu 
    2030                 2035                 2040             


Glu Trp  Met Leu Glu Gly Cys  Arg Ala Ser Gly Gly  Leu Lys Lys 
    2045                 2050                 2055             


Gly Asp  Phe Leu Lys Lys Gly  Leu Glu Pro Glu Thr  Phe Gln Asn 
    2060                 2065                 2070             


Phe Asp  Gly Asp His Ala Cys  Ser Val Arg Asp Asp  Glu Phe Lys 
    2075                 2080                 2085             


Phe Gln  Gly Leu Arg His Thr  Val Thr Ala Arg Gln  Leu Val Glu 
    2090                 2095                 2100             


Ala Lys  Leu Leu Asp Met Arg  Thr Ile Glu Gln Leu  Arg Leu Gly 
    2105                 2110                 2115             


Leu Lys  Thr Val Glu Glu Val  Gln Lys Thr Leu Asn  Lys Phe Leu 
    2120                 2125                 2130             


Thr Lys  Ala Thr Ser Ile Ala  Gly Leu Tyr Leu Glu  Ser Thr Lys 
    2135                 2140                 2145             


Glu Lys  Ile Ser Phe Ala Ser  Ala Ala Glu Arg Ile  Ile Ile Asp 
    2150                 2155                 2160             


Lys Met  Val Ala Leu Ala Phe  Leu Glu Ala Gln Ala  Ala Thr Gly 
    2165                 2170                 2175             


Phe Ile  Ile Asp Pro Ile Ser  Gly Gln Thr Tyr Ser  Val Glu Asp 
    2180                 2185                 2190             


Ala Val  Leu Lys Gly Val Val  Asp Pro Glu Phe Arg  Ile Arg Leu 
    2195                 2200                 2205             


Leu Glu  Ala Glu Lys Ala Ala  Val Gly Tyr Ser Tyr  Ser Ser Lys 
    2210                 2215                 2220             


Thr Leu  Ser Val Phe Gln Ala  Met Glu Asn Arg Met  Leu Asp Arg 
    2225                 2230                 2235             


Gln Lys  Gly Lys His Ile Leu  Glu Ala Gln Ile Ala  Ser Gly Gly 
    2240                 2245                 2250             


Val Ile  Asp Pro Val Arg Gly  Ile Arg Val Pro Pro  Glu Ile Ala 
    2255                 2260                 2265             


Leu Gln  Gln Gly Leu Leu Asn  Asn Ala Ile Leu Gln  Phe Leu His 
    2270                 2275                 2280             


Glu Pro  Ser Ser Asn Thr Arg  Val Phe Pro Asn Pro  Asn Asn Lys 
    2285                 2290                 2295             


Gln Ala  Leu Tyr Tyr Ser Glu  Leu Leu Arg Met Cys  Val Phe Asp 
    2300                 2305                 2310             


Val Glu  Ser Gln Cys Phe Leu  Phe Pro Phe Gly Glu  Arg Asn Ile 
    2315                 2320                 2325             


Ser Asn  Leu Asn Val Lys Lys  Thr His Arg Ile Ser  Val Val Asp 
    2330                 2335                 2340             


Thr Lys  Thr Gly Ser Glu Leu  Thr Val Tyr Glu Ala  Phe Gln Arg 
    2345                 2350                 2355             


Asn Leu  Ile Glu Lys Ser Ile  Tyr Leu Glu Leu Ser  Gly Gln Gln 
    2360                 2365                 2370             


Tyr Gln  Trp Lys Glu Ala Met  Phe Phe Glu Ser Tyr  Gly His Ser 
    2375                 2380                 2385             


Ser His  Met Leu Thr Asp Thr  Lys Thr Gly Leu His  Phe Asn Ile 
    2390                 2395                 2400             


Asn Glu  Ala Ile Glu Gln Gly  Thr Ile Asp Lys Ala  Leu Val Lys 
    2405                 2410                 2415             


Lys Tyr  Gln Glu Gly Leu Ile  Thr Leu Thr Glu Leu  Ala Asp Ser 
    2420                 2425                 2430             


Leu Leu  Ser Arg Leu Val Pro  Lys Lys Asp Leu His  Ser Pro Val 
    2435                 2440                 2445             


Ala Gly  Tyr Trp Leu Thr Ala  Ser Gly Glu Arg Ile  Ser Val Leu 
    2450                 2455                 2460             


Lys Ala  Ser Arg Arg Asn Leu  Val Asp Arg Ile Thr  Ala Leu Arg 
    2465                 2470                 2475             


Cys Leu  Glu Ala Gln Val Ser  Thr Gly Gly Ile Ile  Asp Pro Leu 
    2480                 2485                 2490             


Thr Gly  Lys Lys Tyr Arg Val  Ala Glu Ala Leu His  Arg Gly Leu 
    2495                 2500                 2505             


Val Asp  Glu Gly Phe Ala Gln  Gln Leu Arg Gln Cys  Glu Leu Val 
    2510                 2515                 2520             


Ile Thr  Gly Ile Gly His Pro  Ile Thr Asn Lys Met  Met Ser Val 
    2525                 2530                 2535             


Val Glu  Ala Val Asn Ala Asn  Ile Ile Asn Lys Glu  Met Gly Ile 
    2540                 2545                 2550             


Arg Cys  Leu Glu Phe Gln Tyr  Leu Thr Gly Gly Leu  Ile Glu Pro 
    2555                 2560                 2565             


Gln Val  His Ser Arg Leu Ser  Ile Glu Glu Ala Leu  Gln Val Gly 
    2570                 2575                 2580             


Ile Ile  Asp Val Leu Ile Ala  Thr Lys Leu Lys Asp  Gln Lys Ser 
    2585                 2590                 2595             


Tyr Val  Arg Asn Ile Ile Cys  Pro Gln Thr Lys Arg  Lys Leu Thr 
    2600                 2605                 2610             


Tyr Lys  Glu Ala Leu Glu Lys  Ala Asp Phe Asp Phe  His Thr Gly 
    2615                 2620                 2625             


Leu Lys  Leu Leu Glu Val Ser  Glu Pro Leu Met Thr  Gly Ile Ser 
    2630                 2635                 2640             


Ser Leu  Tyr Tyr Ser Ser 
    2645                 


<210>  4458
<211>  3060
<212>  PRT
<213>  Homo Sapiens

<400>  4458

Met His Ser Ser Ser Tyr Ser Tyr Arg Ser Ser Asp Ser Val Phe Ser 
1               5                   10                  15      


Asn Thr Thr Ser Thr Arg Thr Ser Leu Asp Ser Asn Glu Asn Leu Leu 
            20                  25                  30          


Leu Val His Cys Gly Pro Thr Leu Ile Asn Ser Cys Ile Ser Phe Gly 
        35                  40                  45              


Ser Glu Ser Phe Asp Gly His Arg Leu Glu Met Leu Gln Gln Ile Ala 
    50                  55                  60                  


Asn Arg Val Gln Arg Asp Ser Val Ile Cys Glu Asp Lys Leu Ile Leu 
65                  70                  75                  80  


Ala Gly Asn Ala Leu Gln Ser Asp Ser Lys Arg Leu Glu Ser Gly Val 
                85                  90                  95      


Gln Phe Gln Asn Glu Ala Glu Ile Ala Gly Tyr Ile Leu Glu Cys Glu 
            100                 105                 110         


Asn Leu Leu Arg Gln His Val Ile Asp Val Gln Ile Leu Ile Asp Gly 
        115                 120                 125             


Lys Tyr Tyr Gln Ala Asp Gln Leu Val Gln Arg Val Ala Lys Leu Arg 
    130                 135                 140                 


Asp Glu Ile Met Ala Leu Arg Asn Glu Cys Ser Ser Val Tyr Ser Lys 
145                 150                 155                 160 


Gly Arg Ile Leu Thr Thr Glu Gln Thr Lys Leu Met Ile Ser Gly Ile 
                165                 170                 175     


Thr Gln Ser Leu Asn Ser Gly Phe Ala Gln Thr Leu His Pro Ser Leu 
            180                 185                 190         


Thr Ser Gly Leu Thr Gln Ser Leu Thr Pro Ser Leu Thr Ser Ser Ser 
        195                 200                 205             


Met Thr Ser Gly Leu Ser Ser Gly Met Thr Ser Arg Leu Thr Pro Ser 
    210                 215                 220                 


Val Thr Pro Ala Tyr Thr Pro Gly Phe Pro Ser Gly Leu Val Pro Asn 
225                 230                 235                 240 


Phe Ser Ser Gly Val Glu Pro Asn Ser Leu Gln Thr Leu Lys Leu Met 
                245                 250                 255     


Gln Ile Arg Lys Pro Leu Leu Lys Ser Ser Leu Leu Asp Gln Asn Leu 
            260                 265                 270         


Thr Glu Glu Glu Ile Asn Met Lys Phe Val Gln Asp Leu Leu Asn Trp 
        275                 280                 285             


Val Asp Glu Met Gln Val Gln Leu Asp Arg Thr Glu Trp Gly Ser Asp 
    290                 295                 300                 


Leu Pro Ser Val Glu Ser His Leu Glu Asn His Lys Asn Val His Arg 
305                 310                 315                 320 


Ala Ile Glu Glu Phe Glu Ser Ser Leu Lys Glu Ala Lys Ile Ser Glu 
                325                 330                 335     


Ile Gln Met Thr Ala Pro Leu Lys Leu Thr Tyr Ala Glu Lys Leu His 
            340                 345                 350         


Arg Leu Glu Ser Gln Tyr Ala Lys Leu Leu Asn Thr Ser Arg Asn Gln 
        355                 360                 365             


Glu Arg His Leu Asp Thr Leu His Asn Phe Val Ser Arg Ala Thr Asn 
    370                 375                 380                 


Glu Leu Ile Trp Leu Asn Glu Lys Glu Glu Glu Glu Val Ala Tyr Asp 
385                 390                 395                 400 


Trp Ser Glu Arg Asn Thr Asn Ile Ala Arg Lys Lys Asp Tyr His Ala 
                405                 410                 415     


Glu Leu Met Arg Glu Leu Asp Gln Lys Glu Glu Asn Ile Lys Ser Val 
            420                 425                 430         


Gln Glu Ile Ala Glu Gln Leu Leu Leu Glu Asn His Pro Ala Arg Leu 
        435                 440                 445             


Thr Ile Glu Ala Tyr Arg Ala Ala Met Gln Thr Gln Trp Ser Trp Ile 
    450                 455                 460                 


Leu Gln Leu Cys Gln Cys Val Glu Gln His Ile Lys Glu Asn Thr Ala 
465                 470                 475                 480 


Tyr Phe Glu Phe Phe Asn Asp Ala Lys Glu Ala Thr Asp Tyr Leu Arg 
                485                 490                 495     


Asn Leu Lys Asp Ala Ile Gln Arg Lys Tyr Ser Cys Asp Arg Ser Ser 
            500                 505                 510         


Ser Ile His Lys Leu Glu Asp Leu Val Gln Glu Ser Met Glu Glu Lys 
        515                 520                 525             


Glu Glu Leu Leu Gln Tyr Lys Ser Thr Ile Ala Asn Leu Met Gly Lys 
    530                 535                 540                 


Ala Lys Thr Ile Ile Gln Leu Lys Pro Arg Asn Ser Asp Cys Pro Leu 
545                 550                 555                 560 


Lys Thr Ser Ile Pro Ile Lys Ala Ile Cys Asp Tyr Arg Gln Ile Glu 
                565                 570                 575     


Ile Thr Ile Tyr Lys Asp Asp Glu Cys Val Leu Ala Asn Asn Ser His 
            580                 585                 590         


Arg Ala Lys Trp Lys Val Ile Ser Pro Thr Gly Asn Glu Ala Met Val 
        595                 600                 605             


Pro Ser Val Cys Phe Thr Val Pro Pro Pro Asn Lys Glu Ala Val Asp 
    610                 615                 620                 


Leu Ala Asn Arg Ile Glu Gln Gln Tyr Gln Asn Val Leu Thr Leu Trp 
625                 630                 635                 640 


His Glu Ser His Ile Asn Met Lys Ser Val Val Ser Trp His Tyr Leu 
                645                 650                 655     


Ile Asn Glu Ile Asp Arg Ile Arg Ala Ser Asn Val Ala Ser Ile Lys 
            660                 665                 670         


Thr Met Leu Pro Gly Glu His Gln Gln Val Leu Ser Asn Leu Gln Ser 
        675                 680                 685             


Arg Phe Glu Asp Phe Leu Glu Asp Ser Gln Glu Ser Gln Val Phe Ser 
    690                 695                 700                 


Gly Ser Asp Ile Thr Gln Leu Glu Lys Glu Val Asn Val Cys Lys Gln 
705                 710                 715                 720 


Tyr Tyr Gln Glu Leu Leu Lys Ser Ala Glu Arg Glu Glu Gln Glu Glu 
                725                 730                 735     


Ser Val Tyr Asn Leu Tyr Ile Ser Glu Val Arg Asn Ile Arg Leu Arg 
            740                 745                 750         


Leu Glu Asn Cys Glu Asp Arg Leu Ile Arg Gln Ile Arg Thr Pro Leu 
        755                 760                 765             


Glu Arg Asp Asp Leu His Glu Ser Val Phe Arg Ile Thr Glu Gln Glu 
    770                 775                 780                 


Lys Leu Lys Lys Glu Leu Glu Arg Leu Lys Asp Asp Leu Gly Thr Ile 
785                 790                 795                 800 


Thr Asn Lys Cys Glu Glu Phe Phe Ser Gln Ala Ala Ala Ser Ser Ser 
                805                 810                 815     


Val Pro Thr Leu Arg Ser Glu Leu Asn Val Val Leu Gln Asn Met Asn 
            820                 825                 830         


Gln Val Tyr Ser Met Ser Ser Thr Tyr Ile Asp Lys Leu Lys Thr Val 
        835                 840                 845             


Asn Leu Val Leu Lys Asn Thr Gln Ala Ala Glu Ala Leu Val Lys Leu 
    850                 855                 860                 


Tyr Glu Thr Lys Leu Cys Glu Glu Glu Ala Val Ile Ala Asp Lys Asn 
865                 870                 875                 880 


Asn Ile Glu Asn Leu Ile Ser Thr Leu Lys Gln Trp Arg Ser Glu Val 
                885                 890                 895     


Asp Glu Lys Arg Gln Val Phe His Ala Leu Glu Asp Glu Leu Gln Lys 
            900                 905                 910         


Ala Lys Ala Ile Ser Asp Glu Met Phe Lys Thr Tyr Lys Glu Arg Asp 
        915                 920                 925             


Leu Asp Phe Asp Trp His Lys Glu Lys Ala Asp Gln Leu Val Glu Arg 
    930                 935                 940                 


Trp Gln Asn Val His Val Gln Ile Asp Asn Arg Leu Arg Asp Leu Glu 
945                 950                 955                 960 


Gly Ile Gly Lys Ser Leu Lys Tyr Tyr Arg Asp Thr Tyr His Pro Leu 
                965                 970                 975     


Asp Asp Trp Ile Gln Gln Val Glu Thr Thr Gln Arg Lys Ile Gln Glu 
            980                 985                 990         


Asn Gln Pro Glu Asn Ser Lys Thr  Leu Ala Thr Gln Leu  Asn Gln Gln 
        995                 1000                 1005             


Lys Met  Leu Val Ser Glu Ile  Glu Met Lys Gln Ser  Lys Met Asp 
    1010                 1015                 1020             


Glu Cys  Gln Lys Tyr Ala Glu  Gln Tyr Ser Ala Thr  Val Lys Asp 
    1025                 1030                 1035             


Tyr Glu  Leu Gln Thr Met Thr  Tyr Arg Ala Met Val  Asp Ser Gln 
    1040                 1045                 1050             


Gln Lys  Ser Pro Val Lys Arg  Arg Arg Met Gln Ser  Ser Ala Asp 
    1055                 1060                 1065             


Leu Ile  Ile Gln Glu Phe Met  Asp Leu Arg Thr Arg  Tyr Thr Ala 
    1070                 1075                 1080             


Leu Val  Thr Leu Met Thr Gln  Tyr Ile Lys Phe Ala  Gly Asp Ser 
    1085                 1090                 1095             


Leu Lys  Arg Leu Glu Glu Glu  Glu Lys Ser Leu Glu  Glu Glu Lys 
    1100                 1105                 1110             


Lys Glu  His Val Glu Lys Ala  Lys Glu Leu Gln Lys  Trp Val Ser 
    1115                 1120                 1125             


Asn Ile  Ser Lys Thr Leu Lys  Asp Ala Glu Lys Ala  Gly Lys Pro 
    1130                 1135                 1140             


Pro Phe  Ser Lys Gln Lys Ile  Ser Ser Glu Glu Ile  Ser Thr Lys 
    1145                 1150                 1155             


Lys Glu  Gln Leu Ser Glu Ala  Leu Gln Thr Ile Gln  Leu Phe Leu 
    1160                 1165                 1170             


Ala Lys  His Gly Asp Lys Met  Thr Asp Glu Glu Arg  Asn Glu Leu 
    1175                 1180                 1185             


Glu Lys  Gln Val Lys Thr Leu  Gln Glu Ser Tyr Asn  Leu Leu Phe 
    1190                 1195                 1200             


Ser Glu  Ser Leu Lys Gln Leu  Gln Glu Ser Gln Thr  Ser Gly Asp 
    1205                 1210                 1215             


Val Lys  Val Glu Glu Lys Leu  Asp Lys Val Ile Ala  Gly Thr Ile 
    1220                 1225                 1230             


Asp Gln  Thr Thr Gly Glu Val  Leu Ser Val Phe Gln  Ala Val Leu 
    1235                 1240                 1245             


Arg Gly  Leu Ile Asp Tyr Asp  Thr Gly Ile Arg Leu  Leu Glu Thr 
    1250                 1255                 1260             


Gln Leu  Met Ile Ser Gly Leu  Ile Ser Pro Glu Leu  Arg Lys Cys 
    1265                 1270                 1275             


Phe Asp  Leu Lys Asp Ala Lys  Ser His Gly Leu Ile  Asp Glu Gln 
    1280                 1285                 1290             


Ile Leu  Cys Gln Leu Lys Glu  Leu Ser Lys Ala Lys  Glu Ile Ile 
    1295                 1300                 1305             


Ser Ala  Ala Ser Pro Thr Thr  Ile Pro Val Leu Asp  Ala Leu Ala 
    1310                 1315                 1320             


Gln Ser  Met Ile Thr Glu Ser  Met Ala Ile Lys Val  Leu Glu Ile 
    1325                 1330                 1335             


Leu Leu  Ser Thr Gly Ser Leu  Val Ile Pro Ala Thr  Gly Glu Gln 
    1340                 1345                 1350             


Leu Thr  Leu Gln Lys Ala Phe  Gln Gln Asn Leu Val  Ser Ser Ala 
    1355                 1360                 1365             


Leu Phe  Ser Lys Val Leu Glu  Arg Gln Asn Met Cys  Lys Asp Leu 
    1370                 1375                 1380             


Ile Asp  Pro Cys Thr Ser Glu  Lys Val Ser Leu Ile  Asp Met Val 
    1385                 1390                 1395             


Gln Arg  Ser Thr Leu Gln Glu  Asn Thr Gly Met Trp  Leu Leu Pro 
    1400                 1405                 1410             


Val Arg  Pro Gln Glu Gly Gly  Arg Ile Thr Leu Lys  Cys Gly Arg 
    1415                 1420                 1425             


Asn Ile  Ser Ile Leu Arg Ala  Ala His Glu Gly Leu  Ile Asp Arg 
    1430                 1435                 1440             


Glu Thr  Met Phe Arg Leu Leu  Ser Ala Gln Leu Leu  Ser Gly Gly 
    1445                 1450                 1455             


Leu Ile  Asn Ser Asn Ser Gly  Gln Arg Met Thr Val  Glu Glu Ala 
    1460                 1465                 1470             


Val Arg  Glu Gly Val Ile Asp  Arg Asp Thr Ala Ser  Ser Ile Leu 
    1475                 1480                 1485             


Thr Tyr  Gln Val Gln Thr Gly  Gly Ile Ile Gln Ser  Asn Pro Ala 
    1490                 1495                 1500             


Lys Arg  Leu Thr Val Asp Glu  Ala Val Gln Cys Asp  Leu Ile Thr 
    1505                 1510                 1515             


Ser Ser  Ser Ala Leu Leu Val  Leu Glu Ala Gln Arg  Gly Tyr Val 
    1520                 1525                 1530             


Gly Leu  Ile Trp Pro His Ser  Gly Glu Ile Phe Pro  Thr Ser Ser 
    1535                 1540                 1545             


Ser Leu  Gln Gln Glu Leu Ile  Thr Asn Glu Leu Ala  Tyr Lys Ile 
    1550                 1555                 1560             


Leu Asn  Gly Arg Gln Lys Ile  Ala Ala Leu Tyr Ile  Pro Glu Ser 
    1565                 1570                 1575             


Ser Gln  Val Ile Gly Leu Asp  Ala Ala Lys Gln Leu  Gly Ile Ile 
    1580                 1585                 1590             


Asp Asn  Asn Thr Ala Ser Ile  Leu Lys Asn Ile Thr  Leu Pro Asp 
    1595                 1600                 1605             


Lys Met  Pro Asp Leu Gly Asp  Leu Glu Ala Cys Lys  Asn Ala Arg 
    1610                 1615                 1620             


Arg Trp  Leu Ser Phe Cys Lys  Phe Gln Pro Ser Thr  Val His Asp 
    1625                 1630                 1635             


Tyr Arg  Gln Glu Glu Asp Val  Phe Asp Gly Glu Glu  Pro Val Thr 
    1640                 1645                 1650             


Thr Gln  Thr Ser Glu Glu Thr  Lys Lys Leu Phe Leu  Ser Tyr Leu 
    1655                 1660                 1665             


Met Ile  Asn Ser Tyr Met Asp  Ala Asn Thr Gly Gln  Arg Leu Leu 
    1670                 1675                 1680             


Leu Tyr  Asp Gly Asp Leu Asp  Glu Ala Val Gly Met  Leu Leu Glu 
    1685                 1690                 1695             


Gly Cys  His Ala Glu Phe Asp  Gly Asn Thr Ala Ile  Lys Glu Cys 
    1700                 1705                 1710             


Leu Asp  Val Leu Ser Ser Ser  Gly Val Phe Leu Asn  Asn Ala Ser 
    1715                 1720                 1725             


Gly Arg  Glu Lys Asp Glu Cys  Thr Ala Thr Pro Ser  Ser Phe Asn 
    1730                 1735                 1740             


Lys Cys  His Cys Gly Glu Pro  Glu His Glu Glu Thr  Pro Glu Asn 
    1745                 1750                 1755             


Arg Lys  Cys Ala Ile Asp Glu  Glu Phe Asn Glu Met  Arg Asn Thr 
    1760                 1765                 1770             


Val Ile  Asn Ser Glu Phe Ser  Gln Ser Gly Lys Leu  Ala Ser Thr 
    1775                 1780                 1785             


Ile Ser  Ile Asp Pro Lys Val  Asn Ser Ser Pro Ser  Val Cys Val 
    1790                 1795                 1800             


Pro Ser  Leu Ile Ser Tyr Leu  Thr Gln Thr Glu Leu  Ala Asp Ile 
    1805                 1810                 1815             


Ser Met  Leu Arg Ser Asp Ser  Glu Asn Ile Leu Thr  Asn Tyr Glu 
    1820                 1825                 1830             


Asn Gln  Ser Arg Val Glu Thr  Asn Glu Arg Ala Asn  Glu Cys Ser 
    1835                 1840                 1845             


His Ser  Lys Asn Ile Gln Asn  Phe Pro Ser Asp Leu  Ile Glu Asn 
    1850                 1855                 1860             


Pro Ile  Met Lys Ser Lys Met  Ser Lys Phe Cys Gly  Val Asn Glu 
    1865                 1870                 1875             


Thr Glu  Asn Glu Asp Asn Thr  Asn Arg Asp Ser Pro  Ile Phe Asp 
    1880                 1885                 1890             


Tyr Ser  Pro Arg Leu Ser Ala  Leu Leu Ser His Asp  Lys Leu Met 
    1895                 1900                 1905             


His Ser  Gln Gly Ser Phe Asn  Asp Thr His Thr Pro  Glu Ser Asn 
    1910                 1915                 1920             


Gly Asn  Lys Cys Glu Ala Pro  Ala Leu Ser Phe Ser  Asp Lys Thr 
    1925                 1930                 1935             


Met Leu  Ser Gly Gln Arg Ile  Gly Glu Lys Phe Gln  Asp Gln Phe 
    1940                 1945                 1950             


Leu Gly  Ile Ala Ala Ile Asn  Ile Ser Leu Pro Gly  Glu Gln Tyr 
    1955                 1960                 1965             


Gly Gln  Lys Ser Leu Asn Met  Ile Ser Ser Asn Pro  Gln Val Gln 
    1970                 1975                 1980             


Tyr His  Asn Asp Lys Tyr Ile  Ser Asn Thr Ser Gly  Glu Asp Glu 
    1985                 1990                 1995             


Lys Thr  His Pro Gly Phe Gln  Gln Met Pro Glu Asp  Lys Glu Asp 
    2000                 2005                 2010             


Glu Ser  Glu Ile Glu Glu Tyr  Ser Cys Ala Val Thr  Pro Gly Gly 
    2015                 2020                 2025             


Asp Thr  Asp Asn Ala Ile Val  Ser Leu Thr Cys Ala  Thr Pro Leu 
    2030                 2035                 2040             


Leu Asp  Glu Thr Ile Ser Ala  Ser Asp Tyr Glu Thr  Ser Leu Leu 
    2045                 2050                 2055             


Asn Asp  Gln Gln Asn Asn Thr  Gly Thr Asp Thr Asp  Ser Asp Asp 
    2060                 2065                 2070             


Asp Phe  Tyr Asp Thr Pro Leu  Phe Glu Asp Asp Asp  His Asp Ser 
    2075                 2080                 2085             


Leu Leu  Leu Asp Gly Asp Asp  Arg Asp Cys Leu His  Pro Glu Asp 
    2090                 2095                 2100             


Tyr Asp  Thr Leu Gln Glu Glu  Asn Asp Glu Thr Ala  Ser Pro Ala 
    2105                 2110                 2115             


Asp Val  Phe Tyr Asp Val Ser  Lys Glu Asn Glu Asn  Ser Met Val 
    2120                 2125                 2130             


Pro Gln  Gly Ala Pro Val Gly  Ser Leu Ser Val Lys  Asn Lys Ala 
    2135                 2140                 2145             


His Cys  Leu Gln Asp Phe Leu  Met Asp Val Glu Lys  Asp Glu Leu 
    2150                 2155                 2160             


Asp Ser  Gly Glu Lys Ile His  Leu Asn Pro Val Gly  Ser Asp Lys 
    2165                 2170                 2175             


Val Asn  Gly Gln Ser Leu Glu  Thr Gly Ser Glu Arg  Glu Cys Thr 
    2180                 2185                 2190             


Asn Ile  Leu Glu Gly Asp Glu  Ser Asp Ser Leu Thr  Asp Tyr Asp 
    2195                 2200                 2205             


Ile Val  Gly Gly Lys Glu Ser  Phe Thr Ala Ser Leu  Lys Phe Asp 
    2210                 2215                 2220             


Asp Ser  Gly Ser Trp Arg Gly  Arg Lys Glu Glu Tyr  Val Thr Gly 
    2225                 2230                 2235             


Gln Glu  Phe His Ser Asp Thr  Asp His Leu Asp Ser  Met Gln Ser 
    2240                 2245                 2250             


Glu Glu  Ser Tyr Gly Asp Tyr  Ile Tyr Asp Ser Asn  Asp Gln Asp 
    2255                 2260                 2265             


Asp Asp  Asp Asp Asp Gly Ile  Asp Glu Glu Gly Gly  Gly Ile Arg 
    2270                 2275                 2280             


Asp Glu  Asn Gly Lys Pro Arg  Cys Gln Asn Val Ala  Glu Asp Met 
    2285                 2290                 2295             


Asp Ile  Gln Leu Cys Ala Ser  Ile Leu Asn Glu Asn  Ser Asp Glu 
    2300                 2305                 2310             


Asn Glu  Asn Ile Asn Thr Met  Ile Leu Leu Asp Lys  Met His Ser 
    2315                 2320                 2325             


Cys Ser  Ser Leu Glu Lys Gln  Gln Arg Val Asn Val  Val Gln Leu 
    2330                 2335                 2340             


Ala Ser  Pro Ser Glu Asn Asn  Leu Val Thr Glu Lys  Ser Asn Leu 
    2345                 2350                 2355             


Pro Glu  Tyr Thr Thr Glu Ile  Ala Gly Lys Ser Lys  Glu Asn Leu 
    2360                 2365                 2370             


Leu Asn  His Glu Met Val Leu  Lys Asp Val Leu Pro  Pro Ile Ile 
    2375                 2380                 2385             


Lys Asp  Thr Glu Ser Glu Lys  Thr Phe Gly Pro Ala  Ser Ile Ser 
    2390                 2395                 2400             


His Asp  Asn Asn Asn Ile Ser  Ser Thr Ser Glu Leu  Gly Thr Asp 
    2405                 2410                 2415             


Leu Ala  Asn Thr Lys Val Lys  Leu Ile Gln Gly Ser  Glu Leu Pro 
    2420                 2425                 2430             


Glu Leu  Thr Asp Ser Val Lys  Gly Lys Asp Glu Tyr  Phe Lys Asn 
    2435                 2440                 2445             


Met Thr  Pro Lys Val Asp Ser  Ser Leu Asp His Ile  Ile Cys Thr 
    2450                 2455                 2460             


Glu Pro  Asp Leu Ile Gly Lys  Pro Ala Glu Glu Ser  His Leu Ser 
    2465                 2470                 2475             


Leu Ile  Ala Ser Val Thr Asp  Lys Asp Pro Gln Gly  Asn Gly Ser 
    2480                 2485                 2490             


Asp Leu  Ile Lys Gly Arg Asp  Gly Lys Ser Asp Ile  Leu Ile Glu 
    2495                 2500                 2505             


Asp Glu  Thr Ser Ile Gln Lys  Met Tyr Leu Gly Glu  Gly Glu Val 
    2510                 2515                 2520             


Leu Val  Glu Gly Leu Val Glu  Glu Glu Asn Arg His  Leu Lys Leu 
    2525                 2530                 2535             


Leu Pro  Gly Lys Asn Thr Arg  Asp Ser Phe Lys Leu  Ile Asn Ser 
    2540                 2545                 2550             


Gln Phe  Pro Phe Pro Gln Ile  Thr Asn Asn Glu Glu  Leu Asn Gln 
    2555                 2560                 2565             


Lys Gly  Ser Leu Lys Lys Ala  Thr Val Thr Leu Lys  Asp Glu Pro 
    2570                 2575                 2580             


Asn Asn  Leu Gln Ile Ile Val  Ser Lys Ser Pro Val  Gln Phe Glu 
    2585                 2590                 2595             


Asn Leu  Glu Glu Ile Phe Asp  Thr Ser Val Ser Lys  Glu Ile Ser 
    2600                 2605                 2610             


Asp Asp  Ile Thr Ser Asp Ile  Thr Ser Trp Glu Gly  Asn Thr His 
    2615                 2620                 2625             


Phe Glu  Glu Ser Phe Thr Asp  Gly Pro Glu Lys Glu  Leu Asp Leu 
    2630                 2635                 2640             


Phe Thr  Tyr Leu Lys His Cys  Ala Lys Asn Ile Lys  Ala Lys Asp 
    2645                 2650                 2655             


Val Ala  Lys Pro Asn Glu Asp  Val Pro Ser His Val  Leu Ile Thr 
    2660                 2665                 2670             


Ala Pro  Pro Met Lys Glu His  Leu Gln Leu Gly Val  Asn Asn Thr 
    2675                 2680                 2685             


Lys Glu  Lys Ser Thr Ser Thr  Gln Lys Asp Ser Pro  Leu Asn Asp 
    2690                 2695                 2700             


Met Ile  Gln Ser Asn Asp Leu  Cys Ser Lys Glu Ser  Ile Ser Gly 
    2705                 2710                 2715             


Gly Gly  Thr Glu Ile Ser Gln  Phe Thr Pro Glu Ser  Ile Glu Ala 
    2720                 2725                 2730             


Thr Leu  Ser Ile Leu Ser Arg  Lys His Val Glu Asp  Val Gly Lys 
    2735                 2740                 2745             


Asn Asp  Phe Leu Gln Ser Glu  Arg Cys Ala Asn Gly  Leu Gly Asn 
    2750                 2755                 2760             


Asp Asn  Ser Ser Asn Thr Leu  Asn Thr Asp Tyr Ser  Phe Leu Glu 
    2765                 2770                 2775             


Ile Asn  Asn Lys Lys Glu Arg  Ile Glu Gln Gln Leu  Pro Lys Glu 
    2780                 2785                 2790             


Gln Ala  Leu Ser Pro Arg Ser  Gln Glu Lys Glu Val  Gln Ile Pro 
    2795                 2800                 2805             


Glu Leu  Ser Gln Val Phe Val  Glu Asp Val Lys Asp  Ile Leu Lys 
    2810                 2815                 2820             


Ser Arg  Leu Lys Glu Gly His  Met Asn Pro Gln Glu  Val Glu Glu 
    2825                 2830                 2835             


Pro Ser  Ala Cys Ala Asp Thr  Lys Ile Leu Ile Gln  Asn Leu Ile 
    2840                 2845                 2850             


Lys Arg  Ile Thr Thr Ser Gln  Leu Val Asn Glu Ala  Ser Thr Val 
    2855                 2860                 2865             


Pro Ser  Asp Ser Gln Met Ser  Asp Ser Ser Gly Val  Ser Pro Met 
    2870                 2875                 2880             


Thr Asn  Ser Ser Glu Leu Lys  Pro Glu Ser Arg Asp  Asp Pro Phe 
    2885                 2890                 2895             


Cys Ile  Gly Asn Leu Lys Ser  Glu Leu Leu Leu Asn  Ile Leu Lys 
    2900                 2905                 2910             


Gln Asp  Gln His Ser Gln Lys  Ile Thr Gly Val Phe  Glu Leu Met 
    2915                 2920                 2925             


Arg Glu  Leu Thr His Met Glu  Tyr Asp Leu Glu Lys  Arg Gly Ile 
    2930                 2935                 2940             


Thr Ser  Lys Val Leu Pro Leu  Gln Leu Glu Asn Ile  Phe Tyr Lys 
    2945                 2950                 2955             


Leu Leu  Ala Asp Gly Tyr Ser  Glu Lys Ile Glu His  Val Gly Asp 
    2960                 2965                 2970             


Phe Asn  Gln Lys Ala Cys Ser  Thr Ser Glu Met Met  Glu Glu Lys 
    2975                 2980                 2985             


Pro His  Ile Leu Gly Asp Ile  Lys Ser Lys Glu Gly  Asn Tyr Tyr 
    2990                 2995                 3000             


Ser Pro  Asn Leu Glu Thr Val  Lys Glu Ile Gly Leu  Glu Ser Ser 
    3005                 3010                 3015             


Thr Val  Trp Ala Ser Thr Leu  Pro Arg Asp Glu Lys  Leu Lys Asp 
    3020                 3025                 3030             


Leu Cys  Asn Asp Phe Pro Ser  His Leu Glu Cys Thr  Ser Gly Ser 
    3035                 3040                 3045             


Lys Glu  Met Ala Ser Gly Asp  Ser Ser Thr Glu Gln  
    3050                 3055                 3060 


<210>  4459
<211>  1143
<212>  PRT
<213>  Homo Sapiens

<400>  4459

Met His Ser Ser Ser Tyr Ser Tyr Arg Ser Ser Asp Ser Val Phe Ser 
1               5                   10                  15      


Asn Thr Thr Ser Thr Arg Thr Ser Leu Asp Ser Asn Glu Asn Leu Leu 
            20                  25                  30          


Leu Val His Cys Gly Pro Thr Leu Ile Asn Ser Cys Ile Ser Phe Gly 
        35                  40                  45              


Ser Glu Ser Phe Asp Gly His Arg Leu Glu Met Leu Gln Gln Ile Ala 
    50                  55                  60                  


Asn Arg Val Gln Arg Asp Ser Val Ile Cys Glu Asp Lys Leu Ile Leu 
65                  70                  75                  80  


Ala Gly Asn Ala Leu Gln Ser Asp Ser Lys Arg Leu Glu Ser Gly Val 
                85                  90                  95      


Gln Phe Gln Asn Glu Ala Glu Ile Ala Gly Tyr Ile Leu Glu Cys Glu 
            100                 105                 110         


Asn Leu Leu Arg Gln His Val Ile Asp Val Gln Ile Leu Ile Asp Gly 
        115                 120                 125             


Lys Tyr Tyr Gln Ala Asp Gln Leu Val Gln Arg Val Ala Lys Leu Arg 
    130                 135                 140                 


Asp Glu Ile Met Ala Leu Arg Asn Glu Cys Ser Ser Val Tyr Ser Lys 
145                 150                 155                 160 


Gly Arg Ile Leu Thr Thr Glu Gln Thr Lys Leu Met Ile Ser Gly Ile 
                165                 170                 175     


Thr Gln Ser Leu Asn Ser Gly Phe Ala Gln Thr Leu His Pro Ser Leu 
            180                 185                 190         


Thr Ser Gly Leu Thr Gln Ser Leu Thr Pro Ser Leu Thr Ser Ser Ser 
        195                 200                 205             


Met Thr Ser Gly Leu Ser Ser Gly Met Thr Ser Arg Leu Thr Pro Ser 
    210                 215                 220                 


Val Thr Pro Ala Tyr Thr Pro Gly Phe Pro Ser Gly Leu Val Pro Asn 
225                 230                 235                 240 


Phe Ser Ser Gly Val Glu Pro Asn Ser Leu Gln Thr Leu Lys Leu Met 
                245                 250                 255     


Gln Ile Arg Lys Pro Leu Leu Lys Ser Ser Leu Leu Asp Gln Asn Leu 
            260                 265                 270         


Thr Glu Glu Glu Ile Asn Met Lys Phe Val Gln Asp Leu Leu Asn Trp 
        275                 280                 285             


Val Asp Glu Met Gln Val Gln Leu Asp Arg Thr Glu Trp Gly Ser Asp 
    290                 295                 300                 


Leu Pro Ser Val Glu Ser His Leu Glu Asn His Lys Asn Val His Arg 
305                 310                 315                 320 


Ala Ile Glu Glu Phe Glu Ser Ser Leu Lys Glu Ala Lys Ile Ser Glu 
                325                 330                 335     


Ile Gln Met Thr Ala Pro Leu Lys Leu Thr Tyr Ala Glu Lys Leu His 
            340                 345                 350         


Arg Leu Glu Ser Gln Tyr Ala Lys Leu Leu Asn Thr Ser Arg Asn Gln 
        355                 360                 365             


Glu Arg His Leu Asp Thr Leu His Asn Phe Val Ser Arg Ala Thr Asn 
    370                 375                 380                 


Glu Leu Ile Trp Leu Asn Glu Lys Glu Glu Glu Glu Val Ala Tyr Asp 
385                 390                 395                 400 


Trp Ser Glu Arg Asn Thr Asn Ile Ala Arg Lys Lys Asp Tyr His Ala 
                405                 410                 415     


Glu Leu Met Arg Glu Leu Asp Gln Lys Glu Glu Asn Ile Lys Ser Val 
            420                 425                 430         


Gln Glu Ile Ala Glu Gln Leu Leu Leu Glu Asn His Pro Ala Arg Leu 
        435                 440                 445             


Thr Ile Glu Ala Tyr Arg Ala Ala Met Gln Thr Gln Trp Ser Trp Ile 
    450                 455                 460                 


Leu Gln Leu Cys Gln Cys Val Glu Gln His Ile Lys Glu Asn Thr Ala 
465                 470                 475                 480 


Tyr Phe Glu Phe Phe Asn Asp Ala Lys Glu Ala Thr Asp Tyr Leu Arg 
                485                 490                 495     


Asn Leu Lys Asp Ala Ile Gln Arg Lys Tyr Ser Cys Asp Arg Ser Ser 
            500                 505                 510         


Ser Ile His Lys Leu Glu Asp Leu Val Gln Glu Ser Met Glu Glu Lys 
        515                 520                 525             


Glu Glu Leu Leu Gln Tyr Lys Ser Thr Ile Ala Asn Leu Met Gly Lys 
    530                 535                 540                 


Ala Lys Thr Ile Ile Gln Leu Lys Pro Arg Asn Ser Asp Cys Pro Leu 
545                 550                 555                 560 


Lys Thr Ser Ile Pro Ile Lys Ala Ile Cys Asp Tyr Arg Gln Ile Glu 
                565                 570                 575     


Ile Thr Ile Tyr Lys Asp Asp Glu Cys Val Leu Ala Asn Asn Ser His 
            580                 585                 590         


Arg Ala Lys Trp Lys Val Ile Ser Pro Thr Gly Asn Glu Ala Met Val 
        595                 600                 605             


Pro Ser Val Cys Phe Thr Val Pro Pro Pro Asn Lys Glu Ala Val Asp 
    610                 615                 620                 


Leu Ala Asn Arg Ile Glu Gln Gln Tyr Gln Asn Val Leu Thr Leu Trp 
625                 630                 635                 640 


His Glu Ser His Ile Asn Met Lys Ser Val Val Ser Trp His Tyr Leu 
                645                 650                 655     


Ile Asn Glu Ile Asp Arg Ile Arg Ala Ser Asn Val Ala Ser Ile Lys 
            660                 665                 670         


Thr Met Leu Pro Gly Glu His Gln Gln Val Leu Ser Asn Leu Gln Ser 
        675                 680                 685             


Arg Phe Glu Asp Phe Leu Glu Asp Ser Gln Glu Ser Gln Val Phe Ser 
    690                 695                 700                 


Gly Ser Asp Ile Thr Gln Leu Glu Lys Glu Val Asn Val Cys Lys Gln 
705                 710                 715                 720 


Tyr Tyr Gln Glu Leu Leu Lys Ser Ala Glu Arg Glu Glu Gln Glu Glu 
                725                 730                 735     


Ser Val Tyr Asn Leu Tyr Ile Ser Glu Val Arg Asn Ile Arg Leu Arg 
            740                 745                 750         


Leu Glu Asn Cys Glu Asp Arg Leu Ile Arg Gln Ile Arg Thr Pro Leu 
        755                 760                 765             


Glu Arg Asp Asp Leu His Glu Ser Val Phe Arg Ile Thr Glu Gln Glu 
    770                 775                 780                 


Lys Leu Lys Lys Glu Leu Glu Arg Leu Lys Asp Asp Leu Gly Thr Ile 
785                 790                 795                 800 


Thr Asn Lys Cys Glu Glu Phe Phe Ser Gln Ala Ala Ala Ser Ser Ser 
                805                 810                 815     


Val Pro Thr Leu Arg Ser Glu Leu Asn Val Val Leu Gln Asn Met Asn 
            820                 825                 830         


Gln Val Tyr Ser Met Ser Ser Thr Tyr Ile Asp Lys Leu Lys Thr Val 
        835                 840                 845             


Asn Leu Val Leu Lys Asn Thr Gln Ala Ala Glu Ala Leu Val Lys Leu 
    850                 855                 860                 


Tyr Glu Thr Lys Leu Cys Glu Glu Glu Ala Val Ile Ala Asp Lys Asn 
865                 870                 875                 880 


Asn Ile Glu Asn Leu Ile Ser Thr Leu Lys Gln Trp Arg Ser Glu Val 
                885                 890                 895     


Asp Glu Lys Arg Gln Val Phe His Ala Leu Glu Asp Glu Leu Gln Lys 
            900                 905                 910         


Ala Lys Ala Ile Ser Asp Glu Met Phe Lys Thr Tyr Lys Glu Arg Asp 
        915                 920                 925             


Leu Asp Phe Asp Trp His Lys Glu Lys Ala Asp Gln Leu Val Glu Arg 
    930                 935                 940                 


Trp Gln Asn Val His Val Gln Ile Asp Asn Arg Leu Arg Asp Leu Glu 
945                 950                 955                 960 


Gly Ile Gly Lys Ser Leu Lys Tyr Tyr Arg Asp Thr Tyr His Pro Leu 
                965                 970                 975     


Asp Asp Trp Ile Gln Gln Val Glu Thr Thr Gln Arg Lys Ile Gln Glu 
            980                 985                 990         


Asn Gln Pro Glu Asn Ser Lys Thr  Leu Ala Thr Gln Leu  Asn Gln Gln 
        995                 1000                 1005             


Lys Met  Leu Val Ser Glu Ile  Glu Met Lys Gln Ser  Lys Met Asp 
    1010                 1015                 1020             


Glu Cys  Gln Lys Tyr Ala Glu  Gln Tyr Ser Ala Thr  Val Lys Asp 
    1025                 1030                 1035             


Tyr Glu  Leu Gln Thr Met Thr  Tyr Arg Ala Met Val  Asp Ser Gln 
    1040                 1045                 1050             


Gln Lys  Ser Pro Val Lys Arg  Arg Arg Met Gln Ser  Ser Ala Asp 
    1055                 1060                 1065             


Leu Ile  Ile Gln Glu Phe Met  Asp Leu Arg Thr Arg  Tyr Thr Ala 
    1070                 1075                 1080             


Leu Val  Thr Leu Met Thr Gln  Tyr Ile Lys Phe Ala  Gly Asp Ser 
    1085                 1090                 1095             


Leu Lys  Arg Leu Glu Glu Glu  Glu Val Ile Ile Asn  Ser Glu His 
    1100                 1105                 1110             


Pro Val  Asn Ile Lys Glu Leu  Glu Met Ser Ser Asn  Tyr Ser Val 
    1115                 1120                 1125             


Val Trp  Glu Ser Lys Thr Cys  Phe Met Ile Asn Leu  Cys Gly Arg 
    1130                 1135                 1140             


<210>  4460
<211>  689
<212>  PRT
<213>  Homo Sapiens

<400>  4460

Met Ile Ala Ala Ala Phe Leu Val Leu Leu Arg Pro Tyr Ser Ile Gln 
1               5                   10                  15      


Cys Ala Leu Phe Leu Leu Leu Leu Leu Leu Gly Thr Ile Ala Thr Ile 
            20                  25                  30          


Val Phe Phe Cys Cys Trp His Arg Lys Leu Gln Lys Gly Arg His Pro 
        35                  40                  45              


Met Lys Ser Val Phe Ser Gly Arg Ser Arg Ser Arg Asp Ala Val Leu 
    50                  55                  60                  


Arg Ser His His Phe Arg Ser Glu Gly Phe Arg Ala Ser Pro Arg His 
65                  70                  75                  80  


Leu Arg Arg Arg Val Ala Ala Ala Ala Ala Ala Arg Leu Glu Glu Val 
                85                  90                  95      


Lys Pro Val Val Glu Val His His Gln Ser Glu Gln Glu Thr Ser Val 
            100                 105                 110         


Arg Lys Arg Arg Ile Lys Lys Ser Ser Arg Val Gln Pro Glu Phe Tyr 
        115                 120                 125             


His Ser Val Gln Gly Ala Ser Ile Arg Arg Pro Ser Ser Gly Asn Ala 
    130                 135                 140                 


Ser Tyr Arg Cys Ser Met Ser Ser Ser Ala Asp Phe Ser Asp Glu Asp 
145                 150                 155                 160 


Asp Phe Ser Gln Lys Ser Gly Ser Ala Ser Pro Ala Pro Gly Asp Thr 
                165                 170                 175     


Leu Pro Trp Asn Leu Pro Lys His Glu Arg Ser Lys Arg Lys Ile Gln 
            180                 185                 190         


Gly Gly Ser Val Leu Asp Pro Ala Glu Arg Ala Val Leu Arg Ile Ala 
        195                 200                 205             


Asp Glu Arg Asp Lys Val Gln Lys Lys Thr Phe Thr Lys Trp Ile Asn 
    210                 215                 220                 


Gln His Leu Met Lys Val Arg Lys His Val Asn Asp Leu Tyr Glu Asp 
225                 230                 235                 240 


Leu Arg Asp Gly His Asn Leu Ile Ser Leu Leu Glu Val Leu Ser Gly 
                245                 250                 255     


Asp Thr Leu Pro Arg Glu Lys Gly Arg Met Arg Phe His Arg Leu Gln 
            260                 265                 270         


Asn Val Gln Ile Ala Leu Asp Tyr Leu Lys Arg Arg Gln Val Lys Leu 
        275                 280                 285             


Val Asn Ile Arg Asn Asp Asp Ile Thr Asp Gly Asn Pro Lys Leu Thr 
    290                 295                 300                 


Leu Gly Leu Ile Trp Thr Ile Ile Leu His Phe Gln Ile Ser Asp Ile 
305                 310                 315                 320 


His Val Thr Gly Glu Ser Glu Asp Met Ser Ala Lys Glu Arg Leu Leu 
                325                 330                 335     


Leu Trp Thr Gln Gln Ala Thr Glu Gly Tyr Ala Gly Ile Arg Cys Glu 
            340                 345                 350         


Asn Phe Thr Thr Cys Trp Arg Asp Gly Lys Leu Phe Asn Ala Ile Ile 
        355                 360                 365             


His Lys Tyr Arg Pro Asp Leu Ile Asp Met Asn Thr Val Ala Val Gln 
    370                 375                 380                 


Ser Asn Leu Ala Asn Leu Glu His Ala Phe Tyr Val Ala Glu Lys Ile 
385                 390                 395                 400 


Gly Val Ile Arg Leu Leu Asp Pro Glu Asp Val Asp Val Ser Ser Pro 
                405                 410                 415     


Asp Glu Lys Ser Val Ile Thr Tyr Val Ser Ser Leu Tyr Asp Ala Phe 
            420                 425                 430         


Pro Lys Val Pro Glu Gly Gly Glu Gly Ile Gly Ala Asn Asp Val Glu 
        435                 440                 445             


Val Lys Trp Ile Glu Tyr Gln Asn Met Val Asn Tyr Leu Ile Gln Trp 
    450                 455                 460                 


Ile Arg His His Val Thr Thr Met Ser Glu Arg Thr Phe Pro Asn Asn 
465                 470                 475                 480 


Pro Val Glu Leu Lys Ala Leu Tyr Asn Gln Tyr Leu Gln Phe Lys Glu 
                485                 490                 495     


Thr Glu Ile Pro Pro Lys Glu Thr Glu Lys Ser Lys Ile Lys Arg Leu 
            500                 505                 510         


Tyr Lys Leu Leu Glu Ile Trp Ile Glu Phe Gly Arg Ile Lys Leu Leu 
        515                 520                 525             


Gln Gly Tyr His Pro Asn Asp Ile Glu Lys Glu Trp Gly Lys Leu Ile 
    530                 535                 540                 


Ile Ala Met Leu Glu Arg Glu Lys Ala Leu Arg Pro Glu Val Glu Arg 
545                 550                 555                 560 


Leu Glu Met Leu Gln Gln Ile Ala Asn Arg Val Gln Arg Asp Ser Val 
                565                 570                 575     


Ile Cys Glu Asp Lys Leu Ile Leu Ala Gly Asn Ala Leu Gln Ser Asp 
            580                 585                 590         


Ser Lys Arg Leu Glu Ser Gly Val Gln Phe Gln Asn Glu Ala Glu Ile 
        595                 600                 605             


Ala Gly Tyr Ile Leu Glu Cys Glu Asn Leu Leu Arg Gln His Val Ile 
    610                 615                 620                 


Asp Val Gln Ile Leu Ile Asp Gly Lys Tyr Tyr Gln Ala Asp Gln Leu 
625                 630                 635                 640 


Val Gln Arg Val Ala Lys Leu Arg Asp Glu Ile Met Ala Leu Arg Asn 
                645                 650                 655     


Glu Cys Ser Ser Val Tyr Ser Lys Gly Arg Ile Leu Thr Thr Glu Gln 
            660                 665                 670         


Thr Lys Leu Met Ile Ser Gly Ile Thr Gln Ser Leu Asn Ser Gly Phe 
        675                 680                 685             


Ala 
    


<210>  4461
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  4461

Met Lys Val Arg Lys His Val Asn Asp Leu Tyr Glu Asp Leu Arg Asp 
1               5                   10                  15      


Gly His Asn Leu Ile Ser Leu Leu Glu Val Leu Ser Gly Asp Thr Leu 
            20                  25                  30          


Pro Arg Glu Lys Gly Arg Met Arg Phe His Arg Leu Gln Asn Val Gln 
        35                  40                  45              


Ile Ala Leu Asp Tyr Leu Lys Arg Arg Gln Val Lys Leu Val Asn Ile 
    50                  55                  60                  


Arg Asn Asp Asp Ile Thr Asp Gly Asn Pro Lys Leu Thr Leu Gly Leu 
65                  70                  75                  80  


Ile Trp Thr Ile Ile Leu His Phe Gln Ile Ser Asp Ile His Val Thr 
                85                  90                  95      


Gly Glu Ser Glu Asp Met Ser Ala Lys Glu Arg Leu Leu Leu Trp Thr 
            100                 105                 110         


Gln Gln Ala Thr Glu Gly Tyr Ala Gly Ile Arg Cys Glu Asn Phe Thr 
        115                 120                 125             


Thr Cys Trp Arg Asp 
    130             


<210>  4462
<211>  154
<212>  PRT
<213>  Homo Sapiens

<400>  4462

Met Met Gly Gln Leu Met Lys Asn Asp Gln Asp Trp Asn Ala Lys Leu 
1               5                   10                  15      


Val Gly Leu Met Cys Cys Met Asp Glu Arg Asp Lys Val Gln Lys Lys 
            20                  25                  30          


Thr Phe Thr Lys Trp Ile Asn Gln His Leu Met Lys Val Arg Lys His 
        35                  40                  45              


Val Asn Asp Leu Tyr Glu Asp Leu Arg Asp Gly His Asn Leu Ile Ser 
    50                  55                  60                  


Leu Leu Glu Val Leu Ser Gly Asp Thr Leu Pro Arg Glu Lys Gly Arg 
65                  70                  75                  80  


Met Arg Phe His Arg Leu Gln Asn Val Gln Ile Ala Leu Asp Tyr Leu 
                85                  90                  95      


Lys Arg Arg Gln Val Lys Leu Val Asn Ile Arg Asn Asp Asp Ile Thr 
            100                 105                 110         


Asp Gly Asn Pro Lys Leu Thr Leu Gly Leu Ile Trp Thr Ile Ile Leu 
        115                 120                 125             


His Phe Gln Ile Ser Asp Ile His Val Thr Gly Glu Ser Glu Asp Met 
    130                 135                 140                 


Ser Ala Lys Glu Arg Leu Leu Leu Trp Thr 
145                 150                 


<210>  4463
<211>  5537
<212>  PRT
<213>  Homo Sapiens

<400>  4463

Met Ser Ser Gly Asn Ala Ser Tyr Arg Cys Ser Met Ser Ser Ser Ala 
1               5                   10                  15      


Asp Phe Ser Asp Glu Asp Asp Phe Ser Gln Lys Ser Gly Ser Ala Ser 
            20                  25                  30          


Pro Ala Pro Gly Asp Thr Leu Pro Trp Asn Leu Pro Lys His Glu Arg 
        35                  40                  45              


Ser Lys Arg Lys Ile Gln Gly Gly Ser Val Leu Asp Pro Ala Glu Arg 
    50                  55                  60                  


Ala Val Leu Arg Ile Ala Asp Glu Arg Asp Lys Val Gln Lys Lys Thr 
65                  70                  75                  80  


Phe Thr Lys Trp Ile Asn Gln His Leu Met Lys Val Arg Lys His Val 
                85                  90                  95      


Asn Asp Leu Tyr Glu Asp Leu Arg Asp Gly His Asn Leu Ile Ser Leu 
            100                 105                 110         


Leu Glu Val Leu Ser Gly Asp Thr Leu Pro Arg Glu Lys Gly Arg Met 
        115                 120                 125             


Arg Phe His Arg Leu Gln Asn Val Gln Ile Ala Leu Asp Tyr Leu Lys 
    130                 135                 140                 


Arg Arg Gln Val Lys Leu Val Asn Ile Arg Asn Asp Asp Ile Thr Asp 
145                 150                 155                 160 


Gly Asn Pro Lys Leu Thr Leu Gly Leu Ile Trp Thr Ile Ile Leu His 
                165                 170                 175     


Phe Gln Ile Ser Asp Ile His Val Thr Gly Glu Ser Glu Asp Met Ser 
            180                 185                 190         


Ala Lys Glu Arg Leu Leu Leu Trp Thr Gln Gln Ala Thr Glu Gly Tyr 
        195                 200                 205             


Ala Gly Ile Arg Cys Glu Asn Phe Thr Thr Cys Trp Arg Asp Gly Lys 
    210                 215                 220                 


Leu Phe Asn Ala Ile Ile His Lys Tyr Arg Pro Asp Leu Ile Asp Met 
225                 230                 235                 240 


Asn Thr Val Ala Val Gln Ser Asn Leu Ala Asn Leu Glu His Ala Phe 
                245                 250                 255     


Tyr Val Ala Glu Lys Ile Gly Val Ile Arg Leu Leu Asp Pro Glu Asp 
            260                 265                 270         


Val Asp Val Ser Ser Pro Asp Glu Lys Ser Val Ile Thr Tyr Val Ser 
        275                 280                 285             


Ser Leu Tyr Asp Ala Phe Pro Lys Val Pro Glu Gly Gly Glu Gly Ile 
    290                 295                 300                 


Gly Ala Asn Asp Val Glu Val Lys Trp Ile Glu Tyr Gln Asn Met Val 
305                 310                 315                 320 


Asn Tyr Leu Ile Gln Trp Ile Arg His His Val Thr Thr Met Ser Glu 
                325                 330                 335     


Arg Thr Phe Pro Asn Asn Pro Val Glu Leu Lys Ala Leu Tyr Asn Gln 
            340                 345                 350         


Tyr Leu Gln Phe Lys Glu Thr Glu Ile Pro Pro Lys Glu Thr Glu Lys 
        355                 360                 365             


Ser Lys Ile Lys Arg Leu Tyr Lys Leu Leu Glu Ile Trp Ile Glu Phe 
    370                 375                 380                 


Gly Arg Ile Lys Leu Leu Gln Gly Tyr His Pro Asn Asp Ile Glu Lys 
385                 390                 395                 400 


Glu Trp Gly Lys Leu Ile Ile Ala Met Leu Glu Arg Glu Lys Ala Leu 
                405                 410                 415     


Arg Pro Glu Val Glu Arg Leu Glu Met Leu Gln Gln Ile Ala Asn Arg 
            420                 425                 430         


Val Gln Arg Asp Ser Val Ile Cys Glu Asp Lys Leu Ile Leu Ala Gly 
        435                 440                 445             


Asn Ala Leu Gln Ser Asp Ser Lys Arg Leu Glu Ser Gly Val Gln Phe 
    450                 455                 460                 


Gln Asn Glu Ala Glu Ile Ala Gly Tyr Ile Leu Glu Cys Glu Asn Leu 
465                 470                 475                 480 


Leu Arg Gln His Val Ile Asp Val Gln Ile Leu Ile Asp Gly Lys Tyr 
                485                 490                 495     


Tyr Gln Ala Asp Gln Leu Val Gln Arg Val Ala Lys Leu Arg Asp Glu 
            500                 505                 510         


Ile Met Ala Leu Arg Asn Glu Cys Ser Ser Val Tyr Ser Lys Gly Arg 
        515                 520                 525             


Ile Leu Thr Thr Glu Gln Thr Lys Leu Met Ile Ser Gly Ile Thr Gln 
    530                 535                 540                 


Ser Leu Asn Ser Gly Phe Ala Gln Thr Leu His Pro Ser Leu Thr Ser 
545                 550                 555                 560 


Gly Leu Thr Gln Ser Leu Thr Pro Ser Leu Thr Ser Ser Ser Met Thr 
                565                 570                 575     


Ser Gly Leu Ser Ser Gly Met Thr Ser Arg Leu Thr Pro Ser Val Thr 
            580                 585                 590         


Pro Ala Tyr Thr Pro Gly Phe Pro Ser Gly Leu Val Pro Asn Phe Ser 
        595                 600                 605             


Ser Gly Val Glu Pro Asn Ser Leu Gln Thr Leu Lys Leu Met Gln Ile 
    610                 615                 620                 


Arg Lys Pro Leu Leu Lys Ser Ser Leu Leu Asp Gln Asn Leu Thr Glu 
625                 630                 635                 640 


Glu Glu Ile Asn Met Lys Phe Val Gln Asp Leu Leu Asn Trp Val Asp 
                645                 650                 655     


Glu Met Gln Val Gln Leu Asp Arg Thr Glu Trp Gly Ser Asp Leu Pro 
            660                 665                 670         


Ser Val Glu Ser His Leu Glu Asn His Lys Asn Val His Arg Ala Ile 
        675                 680                 685             


Glu Glu Phe Glu Ser Ser Leu Lys Glu Ala Lys Ile Ser Glu Ile Gln 
    690                 695                 700                 


Met Thr Ala Pro Leu Lys Leu Thr Tyr Ala Glu Lys Leu His Arg Leu 
705                 710                 715                 720 


Glu Ser Gln Tyr Ala Lys Leu Leu Asn Thr Ser Arg Asn Gln Glu Arg 
                725                 730                 735     


His Leu Asp Thr Leu His Asn Phe Val Ser Arg Ala Thr Asn Glu Leu 
            740                 745                 750         


Ile Trp Leu Asn Glu Lys Glu Glu Glu Glu Val Ala Tyr Asp Trp Ser 
        755                 760                 765             


Glu Arg Asn Thr Asn Ile Ala Arg Lys Lys Asp Tyr His Ala Glu Leu 
    770                 775                 780                 


Met Arg Glu Leu Asp Gln Lys Glu Glu Asn Ile Lys Ser Val Gln Glu 
785                 790                 795                 800 


Ile Ala Glu Gln Leu Leu Leu Glu Asn His Pro Ala Arg Leu Thr Ile 
                805                 810                 815     


Glu Ala Tyr Arg Ala Ala Met Gln Thr Gln Trp Ser Trp Ile Leu Gln 
            820                 825                 830         


Leu Cys Gln Cys Val Glu Gln His Ile Lys Glu Asn Thr Ala Tyr Phe 
        835                 840                 845             


Glu Phe Phe Asn Asp Ala Lys Glu Ala Thr Asp Tyr Leu Arg Asn Leu 
    850                 855                 860                 


Lys Asp Ala Ile Gln Arg Lys Tyr Ser Cys Asp Arg Ser Ser Ser Ile 
865                 870                 875                 880 


His Lys Leu Glu Asp Leu Val Gln Glu Ser Met Glu Glu Lys Glu Glu 
                885                 890                 895     


Leu Leu Gln Tyr Lys Ser Thr Ile Ala Asn Leu Met Gly Lys Ala Lys 
            900                 905                 910         


Thr Ile Ile Gln Leu Lys Pro Arg Asn Ser Asp Cys Pro Leu Lys Thr 
        915                 920                 925             


Ser Ile Pro Ile Lys Ala Ile Cys Asp Tyr Arg Gln Ile Glu Ile Thr 
    930                 935                 940                 


Ile Tyr Lys Asp Asp Glu Cys Val Leu Ala Asn Asn Ser His Arg Ala 
945                 950                 955                 960 


Lys Trp Lys Val Ile Ser Pro Thr Gly Asn Glu Ala Met Val Pro Ser 
                965                 970                 975     


Val Cys Phe Thr Val Pro Pro Pro Asn Lys Glu Ala Val Asp Leu Ala 
            980                 985                 990         


Asn Arg Ile Glu Gln Gln Tyr Gln  Asn Val Leu Thr Leu  Trp His Glu 
        995                 1000                 1005             


Ser His  Ile Asn Met Lys Ser  Val Val Ser Trp His  Tyr Leu Ile 
    1010                 1015                 1020             


Asn Glu  Ile Asp Arg Ile Arg  Ala Ser Asn Val Ala  Ser Ile Lys 
    1025                 1030                 1035             


Thr Met  Leu Pro Gly Glu His  Gln Gln Val Leu Ser  Asn Leu Gln 
    1040                 1045                 1050             


Ser Arg  Phe Glu Asp Phe Leu  Glu Asp Ser Gln Glu  Ser Gln Val 
    1055                 1060                 1065             


Phe Ser  Gly Ser Asp Ile Thr  Gln Leu Glu Lys Glu  Val Asn Val 
    1070                 1075                 1080             


Cys Lys  Gln Tyr Tyr Gln Glu  Leu Leu Lys Ser Ala  Glu Arg Glu 
    1085                 1090                 1095             


Glu Gln  Glu Glu Ser Val Tyr  Asn Leu Tyr Ile Ser  Glu Val Arg 
    1100                 1105                 1110             


Asn Ile  Arg Leu Arg Leu Glu  Asn Cys Glu Asp Arg  Leu Ile Arg 
    1115                 1120                 1125             


Gln Ile  Arg Thr Pro Leu Glu  Arg Asp Asp Leu His  Glu Ser Val 
    1130                 1135                 1140             


Phe Arg  Ile Thr Glu Gln Glu  Lys Leu Lys Lys Glu  Leu Glu Arg 
    1145                 1150                 1155             


Leu Lys  Asp Asp Leu Gly Thr  Ile Thr Asn Lys Cys  Glu Glu Phe 
    1160                 1165                 1170             


Phe Ser  Gln Ala Ala Ala Ser  Ser Ser Val Pro Thr  Leu Arg Ser 
    1175                 1180                 1185             


Glu Leu  Asn Val Val Leu Gln  Asn Met Asn Gln Val  Tyr Ser Met 
    1190                 1195                 1200             


Ser Ser  Thr Tyr Ile Asp Lys  Leu Lys Thr Val Asn  Leu Val Leu 
    1205                 1210                 1215             


Lys Asn  Thr Gln Ala Ala Glu  Ala Leu Val Lys Leu  Tyr Glu Thr 
    1220                 1225                 1230             


Lys Leu  Cys Glu Glu Glu Ala  Val Ile Ala Asp Lys  Asn Asn Ile 
    1235                 1240                 1245             


Glu Asn  Leu Ile Ser Thr Leu  Lys Gln Trp Arg Ser  Glu Val Asp 
    1250                 1255                 1260             


Glu Lys  Arg Gln Val Phe His  Ala Leu Glu Asp Glu  Leu Gln Lys 
    1265                 1270                 1275             


Ala Lys  Ala Ile Ser Asp Glu  Met Phe Lys Thr Tyr  Lys Glu Arg 
    1280                 1285                 1290             


Asp Leu  Asp Phe Asp Trp His  Lys Glu Lys Ala Asp  Gln Leu Val 
    1295                 1300                 1305             


Glu Arg  Trp Gln Asn Val His  Val Gln Ile Asp Asn  Arg Leu Arg 
    1310                 1315                 1320             


Asp Leu  Glu Gly Ile Gly Lys  Ser Leu Lys Tyr Tyr  Arg Asp Thr 
    1325                 1330                 1335             


Tyr His  Pro Leu Asp Asp Trp  Ile Gln Gln Val Glu  Thr Thr Gln 
    1340                 1345                 1350             


Arg Lys  Ile Gln Glu Asn Gln  Pro Glu Asn Ser Lys  Thr Leu Ala 
    1355                 1360                 1365             


Thr Gln  Leu Asn Gln Gln Lys  Met Leu Val Ser Glu  Ile Glu Met 
    1370                 1375                 1380             


Lys Gln  Ser Lys Met Asp Glu  Cys Gln Lys Tyr Ala  Glu Gln Tyr 
    1385                 1390                 1395             


Ser Ala  Thr Val Lys Asp Tyr  Glu Leu Gln Thr Met  Thr Tyr Arg 
    1400                 1405                 1410             


Ala Met  Val Asp Ser Gln Gln  Lys Ser Pro Val Lys  Arg Arg Arg 
    1415                 1420                 1425             


Met Gln  Ser Ser Ala Asp Leu  Ile Ile Gln Glu Phe  Met Asp Leu 
    1430                 1435                 1440             


Arg Thr  Arg Tyr Thr Ala Leu  Val Thr Leu Met Thr  Gln Tyr Ile 
    1445                 1450                 1455             


Lys Phe  Ala Gly Asp Ser Leu  Lys Arg Leu Glu Glu  Glu Glu Lys 
    1460                 1465                 1470             


Ser Leu  Glu Glu Glu Lys Lys  Glu His Val Glu Lys  Ala Lys Glu 
    1475                 1480                 1485             


Leu Gln  Lys Trp Val Ser Asn  Ile Ser Lys Thr Leu  Lys Asp Ala 
    1490                 1495                 1500             


Glu Lys  Ala Gly Lys Pro Pro  Phe Ser Lys Gln Lys  Ile Ser Ser 
    1505                 1510                 1515             


Glu Glu  Ile Ser Thr Lys Lys  Glu Gln Leu Ser Glu  Ala Leu Gln 
    1520                 1525                 1530             


Thr Ile  Gln Leu Phe Leu Ala  Lys His Gly Asp Lys  Met Thr Asp 
    1535                 1540                 1545             


Glu Glu  Arg Asn Glu Leu Glu  Lys Gln Val Lys Thr  Leu Gln Glu 
    1550                 1555                 1560             


Ser Tyr  Asn Leu Leu Phe Ser  Glu Ser Leu Lys Gln  Leu Gln Glu 
    1565                 1570                 1575             


Ser Gln  Thr Ser Gly Asp Val  Lys Val Glu Glu Lys  Ile Val Ala 
    1580                 1585                 1590             


Glu Arg  Gln Gln Glu Tyr Lys  Glu Lys Leu Gln Gly  Ile Cys Asp 
    1595                 1600                 1605             


Leu Leu  Thr Gln Thr Glu Asn  Arg Leu Ile Gly His  Gln Glu Ala 
    1610                 1615                 1620             


Phe Met  Ile Gly Asp Gly Thr  Val Glu Leu Lys Lys  Tyr Gln Ser 
    1625                 1630                 1635             


Lys Gln  Glu Glu Leu Gln Lys  Asp Met Gln Gly Ser  Ala Gln Ala 
    1640                 1645                 1650             


Leu Ala  Glu Val Val Lys Asn  Thr Glu Asn Phe Leu  Lys Glu Asn 
    1655                 1660                 1665             


Gly Glu  Lys Leu Ser Gln Glu  Asp Lys Ala Leu Ile  Glu Gln Lys 
    1670                 1675                 1680             


Leu Asn  Glu Ala Lys Ile Lys  Cys Glu Gln Leu Asn  Leu Lys Ala 
    1685                 1690                 1695             


Glu Gln  Ser Lys Lys Glu Leu  Asp Lys Val Val Thr  Thr Ala Ile 
    1700                 1705                 1710             


Lys Glu  Glu Thr Glu Lys Val  Ala Ala Val Lys Gln  Leu Glu Glu 
    1715                 1720                 1725             


Ser Lys  Thr Lys Ile Glu Asn  Leu Leu Asp Trp Leu  Ser Asn Val 
    1730                 1735                 1740             


Asp Lys  Asp Ser Glu Arg Ala  Gly Thr Lys His Lys  Gln Val Ile 
    1745                 1750                 1755             


Glu Gln  Asn Gly Thr His Phe  Gln Glu Gly Asp Gly  Lys Ser Ala 
    1760                 1765                 1770             


Ile Gly  Glu Glu Asp Glu Val  Asn Gly Asn Leu Leu  Glu Thr Asp 
    1775                 1780                 1785             


Val Asp  Gly Gln Val Gly Thr  Thr Gln Glu Asn Leu  Asn Gln Gln 
    1790                 1795                 1800             


Tyr Gln  Lys Val Lys Ala Gln  His Glu Lys Ile Ile  Ser Gln His 
    1805                 1810                 1815             


Gln Ala  Val Ile Ile Ala Thr  Gln Ser Ala Gln Val  Leu Leu Glu 
    1820                 1825                 1830             


Lys Gln  Gly Gln Tyr Leu Ser  Pro Glu Glu Lys Glu  Lys Leu Gln 
    1835                 1840                 1845             


Lys Asn  Met Lys Glu Leu Lys  Val His Tyr Glu Thr  Ala Leu Ala 
    1850                 1855                 1860             


Glu Ser  Glu Lys Lys Met Lys  Leu Thr His Ser Leu  Gln Glu Glu 
    1865                 1870                 1875             


Leu Glu  Lys Phe Asp Ala Asp  Tyr Thr Glu Phe Glu  His Trp Leu 
    1880                 1885                 1890             


Gln Gln  Ser Glu Gln Glu Leu  Glu Asn Leu Glu Ala  Gly Ala Asp 
    1895                 1900                 1905             


Asp Ile  Asn Gly Leu Met Thr  Lys Leu Lys Arg Gln  Lys Ser Phe 
    1910                 1915                 1920             


Ser Glu  Asp Val Ile Ser His  Lys Gly Asp Leu Arg  Tyr Ile Thr 
    1925                 1930                 1935             


Ile Ser  Gly Asn Arg Val Leu  Glu Ala Ala Lys Ser  Cys Ser Lys 
    1940                 1945                 1950             


Arg Asp  Gly Gly Lys Val Asp  Thr Ser Ala Thr His  Arg Glu Val 
    1955                 1960                 1965             


Gln Arg  Lys Leu Asp His Ala  Thr Asp Arg Phe Arg  Ser Leu Tyr 
    1970                 1975                 1980             


Ser Lys  Cys Asn Val Leu Gly  Asn Asn Leu Lys Asp  Leu Val Asp 
    1985                 1990                 1995             


Lys Tyr  Gln His Tyr Glu Asp  Ala Ser Cys Gly Leu  Leu Ala Gly 
    2000                 2005                 2010             


Leu Gln  Ala Cys Glu Ala Thr  Ala Ser Lys His Leu  Ser Glu Pro 
    2015                 2020                 2025             


Ile Ala  Val Asp Pro Lys Asn  Leu Gln Arg Gln Leu  Glu Glu Thr 
    2030                 2035                 2040             


Lys Ala  Leu Gln Gly Gln Ile  Ser Ser Gln Gln Val  Ala Val Glu 
    2045                 2050                 2055             


Lys Leu  Lys Lys Thr Ala Glu  Val Leu Leu Asp Ala  Arg Gly Ser 
    2060                 2065                 2070             


Leu Leu  Pro Ala Lys Asn Asp  Ile Gln Lys Thr Leu  Asp Asp Ile 
    2075                 2080                 2085             


Val Gly  Arg Tyr Glu Asp Leu  Ser Lys Ser Val Asn  Glu Arg Asn 
    2090                 2095                 2100             


Glu Lys  Leu Gln Ile Thr Leu  Thr Arg Ser Leu Ser  Val Gln Asp 
    2105                 2110                 2115             


Gly Leu  Asp Glu Met Leu Asp  Trp Met Gly Asn Val  Glu Ser Ser 
    2120                 2125                 2130             


Leu Lys  Glu Gln Gly Gln Val  Pro Leu Asn Ser Thr  Ala Leu Gln 
    2135                 2140                 2145             


Asp Ile  Ile Ser Lys Asn Ile  Met Leu Glu Gln Asp  Ile Ala Gly 
    2150                 2155                 2160             


Arg Gln  Ser Ser Ile Asn Ala  Met Asn Glu Lys Val  Lys Lys Phe 
    2165                 2170                 2175             


Met Glu  Thr Thr Asp Pro Ser  Thr Ala Ser Ser Leu  Gln Ala Lys 
    2180                 2185                 2190             


Met Lys  Asp Leu Ser Ala Arg  Phe Ser Glu Ala Ser  His Lys His 
    2195                 2200                 2205             


Lys Glu  Thr Leu Ala Lys Met  Glu Glu Leu Lys Thr  Lys Val Glu 
    2210                 2215                 2220             


Leu Phe  Glu Asn Leu Ser Glu  Lys Leu Gln Thr Phe  Leu Glu Thr 
    2225                 2230                 2235             


Lys Thr  Gln Ala Leu Thr Glu  Val Asp Val Pro Gly  Lys Asp Val 
    2240                 2245                 2250             


Thr Glu  Leu Ser Gln Tyr Met  Gln Glu Ser Thr Ser  Glu Phe Leu 
    2255                 2260                 2265             


Glu His  Lys Lys His Leu Glu  Val Leu His Ser Leu  Leu Lys Glu 
    2270                 2275                 2280             


Ile Ser  Ser His Gly Leu Pro  Ser Asp Lys Ala Leu  Val Leu Glu 
    2285                 2290                 2295             


Lys Thr  Asn Asn Leu Ser Lys  Lys Phe Lys Glu Met  Glu Asp Thr 
    2300                 2305                 2310             


Ile Lys  Glu Lys Lys Glu Ala  Val Thr Ser Cys Gln  Glu Gln Leu 
    2315                 2320                 2325             


Asp Ala  Phe Gln Val Leu Val  Lys Ser Leu Lys Ser  Trp Ile Lys 
    2330                 2335                 2340             


Glu Thr  Thr Lys Lys Val Pro  Ile Val Gln Pro Ser  Phe Gly Ala 
    2345                 2350                 2355             


Glu Asp  Leu Gly Lys Ser Leu  Glu Asp Thr Lys Lys  Leu Gln Glu 
    2360                 2365                 2370             


Lys Trp  Ser Leu Lys Thr Pro  Glu Ile Gln Lys Val  Asn Asn Ser 
    2375                 2380                 2385             


Gly Ile  Ser Leu Cys Asn Leu  Ile Ser Ala Val Thr  Thr Pro Ala 
    2390                 2395                 2400             


Lys Ala  Ile Ala Ala Val Lys  Ser Gly Gly Ala Val  Leu Asn Gly 
    2405                 2410                 2415             


Glu Gly  Thr Ala Thr Asn Thr  Glu Glu Phe Trp Ala  Asn Lys Gly 
    2420                 2425                 2430             


Leu Thr  Ser Ile Lys Lys Asp  Met Thr Asp Ile Ser  His Gly Tyr 
    2435                 2440                 2445             


Glu Asp  Leu Gly Leu Leu Leu  Lys Asp Lys Ile Ala  Glu Leu Asn 
    2450                 2455                 2460             


Thr Lys  Leu Ser Lys Leu Gln  Lys Ala Gln Glu Glu  Ser Ser Ala 
    2465                 2470                 2475             


Met Met  Gln Trp Leu Gln Lys  Met Asn Lys Thr Ala  Thr Lys Trp 
    2480                 2485                 2490             


Gln Gln  Thr Pro Ala Pro Thr  Asp Thr Glu Ala Val  Lys Thr Gln 
    2495                 2500                 2505             


Val Glu  Gln Asn Lys Ser Phe  Glu Ala Glu Leu Lys  Gln Asn Val 
    2510                 2515                 2520             


Asn Lys  Val Gln Glu Leu Lys  Asp Lys Leu Thr Glu  Leu Leu Glu 
    2525                 2530                 2535             


Glu Asn  Pro Asp Thr Pro Glu  Ala Pro Arg Trp Lys  Gln Met Leu 
    2540                 2545                 2550             


Thr Glu  Ile Asp Ser Lys Trp  Gln Glu Leu Asn Gln  Leu Thr Ile 
    2555                 2560                 2565             


Asp Arg  Gln Gln Lys Leu Glu  Glu Ser Ser Asn Asn  Leu Thr Gln 
    2570                 2575                 2580             


Phe Gln  Thr Val Glu Ala Gln  Leu Lys Gln Trp Leu  Val Glu Lys 
    2585                 2590                 2595             


Glu Leu  Met Val Ser Val Leu  Gly Pro Leu Ser Ile  Asp Pro Asn 
    2600                 2605                 2610             


Met Leu  Asn Thr Gln Arg Gln  Gln Val Gln Ile Leu  Leu Gln Glu 
    2615                 2620                 2625             


Phe Ala  Thr Arg Lys Pro Gln  Tyr Glu Gln Leu Thr  Ala Ala Gly 
    2630                 2635                 2640             


Gln Gly  Ile Leu Ser Arg Pro  Gly Glu Asp Pro Ser  Leu Arg Gly 
    2645                 2650                 2655             


Ile Val  Lys Glu Gln Leu Ala  Ala Val Thr Gln Lys  Trp Asp Ser 
    2660                 2665                 2670             


Leu Thr  Gly Gln Leu Ser Asp  Arg Cys Asp Trp Ile  Asp Gln Ala 
    2675                 2680                 2685             


Ile Val  Lys Ser Thr Gln Tyr  Gln Ser Leu Leu Arg  Ser Leu Ser 
    2690                 2695                 2700             


Asp Lys  Leu Ser Asp Leu Asp  Asn Lys Leu Ser Ser  Ser Leu Ala 
    2705                 2710                 2715             


Val Ser  Thr His Pro Asp Ala  Met Asn Gln Gln Leu  Glu Thr Ala 
    2720                 2725                 2730             


Gln Lys  Met Lys Gln Glu Ile  Gln Gln Glu Lys Lys  Gln Ile Lys 
    2735                 2740                 2745             


Val Ala  Gln Ala Leu Cys Glu  Asp Leu Ser Ala Leu  Val Lys Glu 
    2750                 2755                 2760             


Glu Tyr  Leu Lys Ala Glu Leu  Ser Arg Gln Leu Glu  Gly Ile Leu 
    2765                 2770                 2775             


Lys Ser  Phe Lys Asp Val Glu  Gln Lys Ala Glu Asn  His Val Gln 
    2780                 2785                 2790             


His Leu  Gln Ser Ala Cys Ala  Ser Ser His Gln Phe  Gln Gln Met 
    2795                 2800                 2805             


Ser Arg  Asp Phe Gln Ala Trp  Leu Asp Thr Lys Lys  Glu Glu Gln 
    2810                 2815                 2820             


Asn Lys  Ser His Pro Ile Ser  Ala Lys Leu Asp Val  Leu Glu Ser 
    2825                 2830                 2835             


Leu Ile  Lys Asp His Lys Asp  Phe Ser Lys Thr Leu  Thr Ala Gln 
    2840                 2845                 2850             


Ser His  Met Tyr Glu Lys Thr  Ile Ala Glu Gly Glu  Asn Leu Leu 
    2855                 2860                 2865             


Leu Lys  Thr Gln Gly Ser Glu  Lys Ala Ala Leu Gln  Leu Gln Leu 
    2870                 2875                 2880             


Asn Thr  Ile Lys Thr Asn Trp  Asp Thr Phe Asn Lys  Gln Val Lys 
    2885                 2890                 2895             


Glu Arg  Glu Asn Lys Leu Lys  Glu Ser Leu Glu Lys  Ala Leu Lys 
    2900                 2905                 2910             


Tyr Lys  Glu Gln Val Glu Thr  Leu Trp Pro Trp Ile  Asp Lys Cys 
    2915                 2920                 2925             


Gln Asn  Asn Leu Glu Glu Ile  Lys Phe Cys Leu Asp  Pro Ala Glu 
    2930                 2935                 2940             


Gly Glu  Asn Ser Ile Ala Lys  Leu Lys Ser Leu Gln  Lys Glu Met 
    2945                 2950                 2955             


Asp Gln  His Phe Gly Met Val  Glu Leu Leu Asn Asn  Thr Ala Asn 
    2960                 2965                 2970             


Ser Leu  Leu Ser Val Cys Glu  Ile Asp Lys Glu Val  Val Thr Asp 
    2975                 2980                 2985             


Glu Asn  Lys Ser Leu Ile Gln  Lys Val Asp Met Val  Thr Glu Gln 
    2990                 2995                 3000             


Leu His  Ser Lys Lys Phe Cys  Leu Glu Asn Met Thr  Gln Lys Phe 
    3005                 3010                 3015             


Lys Glu  Phe Gln Glu Val Ser  Lys Glu Ser Lys Arg  Gln Leu Gln 
    3020                 3025                 3030             


Cys Ala  Lys Glu Gln Leu Asp  Ile His Asp Ser Leu  Gly Ser Gln 
    3035                 3040                 3045             


Ala Tyr  Ser Asn Lys Tyr Leu  Thr Met Leu Gln Thr  Gln Gln Lys 
    3050                 3055                 3060             


Ser Leu  Gln Ala Leu Lys His  Gln Val Asp Leu Ala  Lys Arg Leu 
    3065                 3070                 3075             


Ala Gln  Asp Leu Val Val Glu  Ala Ser Asp Ser Lys  Gly Thr Ser 
    3080                 3085                 3090             


Asp Val  Leu Leu Gln Val Glu  Thr Ile Ala Gln Glu  His Ser Thr 
    3095                 3100                 3105             


Leu Ser  Gln Gln Val Asp Glu  Lys Cys Ser Phe Leu  Glu Thr Lys 
    3110                 3115                 3120             


Leu Gln  Gly Ile Gly His Phe  Gln Asn Thr Ile Arg  Glu Met Phe 
    3125                 3130                 3135             


Ser Gln  Phe Ala Glu Phe Asp  Asp Glu Leu Asp Ser  Met Ala Pro 
    3140                 3145                 3150             


Val Gly  Arg Asp Ala Glu Thr  Leu Gln Lys Gln Lys  Glu Thr Ile 
    3155                 3160                 3165             


Lys Ala  Phe Leu Lys Lys Leu  Glu Ala Leu Met Ala  Ser Asn Asp 
    3170                 3175                 3180             


Asn Ala  Asn Lys Thr Cys Lys  Met Met Leu Ala Thr  Glu Glu Thr 
    3185                 3190                 3195             


Ser Pro  Asp Leu Val Gly Ile  Lys Arg Asp Leu Glu  Ala Leu Ser 
    3200                 3205                 3210             


Lys Gln  Cys Asn Lys Leu Leu  Asp Arg Ala Gln Ala  Arg Glu Glu 
    3215                 3220                 3225             


Gln Val  Glu Gly Thr Ile Lys  Arg Leu Glu Glu Phe  Tyr Ser Lys 
    3230                 3235                 3240             


Leu Lys  Glu Phe Ser Ile Leu  Leu Gln Lys Ala Glu  Glu His Glu 
    3245                 3250                 3255             


Glu Ser  Gln Gly Pro Val Gly  Met Glu Thr Glu Thr  Ile Asn Gln 
    3260                 3265                 3270             


Gln Leu  Asn Met Phe Lys Val  Phe Gln Lys Glu Glu  Ile Glu Pro 
    3275                 3280                 3285             


Leu Gln  Gly Lys Gln Gln Asp  Val Asn Trp Leu Gly  Gln Gly Leu 
    3290                 3295                 3300             


Ile Gln  Ser Ala Ala Lys Ser  Thr Ser Thr Gln Gly  Leu Glu His 
    3305                 3310                 3315             


Asp Leu  Asp Asp Val Asn Ala  Arg Trp Lys Thr Leu  Asn Lys Lys 
    3320                 3325                 3330             


Val Ala  Gln Arg Ala Ala Gln  Leu Gln Glu Ala Leu  Leu His Cys 
    3335                 3340                 3345             


Gly Arg  Phe Gln Asp Ala Leu  Glu Ser Leu Leu Ser  Trp Met Val 
    3350                 3355                 3360             


Asp Thr  Glu Glu Leu Val Ala  Asn Gln Lys Pro Pro  Ser Ala Glu 
    3365                 3370                 3375             


Phe Lys  Val Val Lys Ala Gln  Ile Gln Glu Gln Lys  Leu Leu Gln 
    3380                 3385                 3390             


Arg Leu  Leu Asp Asp Arg Lys  Ser Thr Val Glu Val  Ile Lys Arg 
    3395                 3400                 3405             


Glu Gly  Glu Lys Ile Ala Thr  Thr Ala Glu Pro Ala  Asp Lys Val 
    3410                 3415                 3420             


Lys Ile  Leu Lys Gln Leu Ser  Leu Leu Asp Ser Arg  Trp Glu Ala 
    3425                 3430                 3435             


Leu Leu  Asn Lys Ala Glu Thr  Arg Asn Arg Gln Leu  Glu Gly Ile 
    3440                 3445                 3450             


Ser Val  Val Ala Gln Gln Phe  His Glu Thr Leu Glu  Pro Leu Asn 
    3455                 3460                 3465             


Glu Trp  Leu Thr Thr Ile Glu  Lys Arg Leu Val Asn  Cys Glu Pro 
    3470                 3475                 3480             


Ile Gly  Thr Gln Ala Ser Lys  Leu Glu Glu Gln Ile  Ala Gln His 
    3485                 3490                 3495             


Lys Ala  Leu Glu Asp Asp Ile  Ile Asn His Asn Lys  His Leu His 
    3500                 3505                 3510             


Gln Ala  Val Ser Ile Gly Gln  Ser Leu Lys Val Leu  Ser Ser Arg 
    3515                 3520                 3525             


Glu Asp  Lys Asp Met Val Gln  Ser Lys Leu Asp Phe  Ser Gln Val 
    3530                 3535                 3540             


Trp Tyr  Ile Glu Ile Gln Glu  Lys Ser His Ser Arg  Ser Glu Leu 
    3545                 3550                 3555             


Leu Gln  Gln Ala Leu Cys Asn  Ala Lys Ile Phe Gly  Glu Asp Glu 
    3560                 3565                 3570             


Val Glu  Leu Met Asn Trp Leu  Asn Glu Val His Asp  Lys Leu Ser 
    3575                 3580                 3585             


Lys Leu  Ser Val Gln Asp Tyr  Ser Thr Glu Gly Leu  Trp Lys Gln 
    3590                 3595                 3600             


Gln Ser  Glu Leu Arg Val Leu  Gln Glu Asp Ile Leu  Leu Arg Lys 
    3605                 3610                 3615             


Gln Asn  Val Asp Gln Ala Leu  Leu Asn Gly Leu Glu  Leu Leu Lys 
    3620                 3625                 3630             


Gln Thr  Thr Gly Asp Glu Val  Leu Ile Ile Gln Asp  Lys Leu Glu 
    3635                 3640                 3645             


Ala Ile  Lys Ala Arg Tyr Lys  Asp Ile Thr Lys Leu  Ser Thr Asp 
    3650                 3655                 3660             


Val Ala  Lys Thr Leu Glu Gln  Ala Leu Gln Leu Ala  Arg Arg Leu 
    3665                 3670                 3675             


His Ser  Thr His Glu Glu Leu  Cys Thr Trp Leu Asp  Lys Val Glu 
    3680                 3685                 3690             


Val Glu  Leu Leu Ser Tyr Glu  Thr Gln Val Leu Lys  Gly Glu Glu 
    3695                 3700                 3705             


Ala Ser  Gln Ala Gln Met Arg  Pro Lys Glu Leu Lys  Lys Glu Ala 
    3710                 3715                 3720             


Lys Asn  Asn Lys Ala Leu Leu  Asp Ser Leu Asn Glu  Val Ser Ser 
    3725                 3730                 3735             


Ala Leu  Leu Glu Leu Val Pro  Trp Arg Ala Arg Glu  Gly Leu Glu 
    3740                 3745                 3750             


Lys Met  Val Ala Glu Asp Asn  Glu Arg Tyr Arg Leu  Val Ser Asp 
    3755                 3760                 3765             


Thr Ile  Thr Gln Lys Val Glu  Glu Ile Asp Ala Ala  Ile Leu Arg 
    3770                 3775                 3780             


Ser Gln  Gln Phe Asp Gln Ala  Ala Asp Ala Glu Leu  Ser Trp Ile 
    3785                 3790                 3795             


Thr Glu  Thr Glu Lys Lys Leu  Met Ser Leu Gly Asp  Ile Arg Leu 
    3800                 3805                 3810             


Glu Gln  Asp Gln Thr Ser Ala  Gln Leu Gln Val Gln  Lys Thr Phe 
    3815                 3820                 3825             


Thr Met  Glu Ile Leu Arg His  Lys Asp Ile Ile Asp  Asp Leu Val 
    3830                 3835                 3840             


Lys Ser  Gly His Lys Ile Met  Thr Ala Cys Ser Glu  Glu Glu Lys 
    3845                 3850                 3855             


Gln Ser  Met Lys Lys Lys Leu  Asp Lys Val Leu Lys  Asn Tyr Asp 
    3860                 3865                 3870             


Thr Ile  Cys Gln Ile Asn Ser  Glu Arg Tyr Leu Gln  Leu Glu Arg 
    3875                 3880                 3885             


Ala Gln  Ser Leu Val Asn Gln  Phe Trp Glu Thr Tyr  Glu Glu Leu 
    3890                 3895                 3900             


Trp Pro  Trp Leu Thr Glu Thr  Gln Ser Ile Ile Ser  Gln Leu Pro 
    3905                 3910                 3915             


Ala Pro  Ala Leu Glu Tyr Glu  Thr Leu Arg Gln Gln  Gln Glu Glu 
    3920                 3925                 3930             


His Arg  Gln Leu Arg Glu Leu  Ile Ala Glu His Lys  Pro His Ile 
    3935                 3940                 3945             


Asp Lys  Met Asn Lys Thr Gly  Pro Gln Leu Leu Glu  Leu Ser Pro 
    3950                 3955                 3960             


Gly Glu  Gly Phe Ser Ile Gln  Glu Lys Tyr Val Ala  Ala Asp Thr 
    3965                 3970                 3975             


Leu Tyr  Ser Gln Ile Lys Glu  Asp Val Lys Lys Arg  Ala Val Ala 
    3980                 3985                 3990             


Leu Asp  Glu Ala Ile Ser Gln  Ser Thr Gln Phe His  Asp Lys Ile 
    3995                 4000                 4005             


Asp Gln  Ile Leu Glu Ser Leu  Glu Arg Ile Val Glu  Arg Leu Arg 
    4010                 4015                 4020             


Gln Pro  Pro Ser Ile Ser Ala  Glu Val Glu Lys Ile  Lys Glu Gln 
    4025                 4030                 4035             


Ile Ser  Glu Asn Lys Asn Val  Ser Val Asp Met Glu  Lys Leu Gln 
    4040                 4045                 4050             


Pro Leu  Tyr Glu Thr Leu Lys  Gln Arg Gly Glu Glu  Met Ile Ala 
    4055                 4060                 4065             


Arg Ser  Gly Gly Thr Asp Lys  Asp Ile Ser Ala Lys  Ala Val Gln 
    4070                 4075                 4080             


Asp Lys  Leu Asp Gln Met Val  Phe Ile Trp Glu Asn  Ile His Thr 
    4085                 4090                 4095             


Leu Val  Glu Glu Arg Glu Ala  Lys Leu Leu Asp Val  Met Glu Leu 
    4100                 4105                 4110             


Ala Glu  Lys Phe Trp Cys Asp  His Met Ser Leu Ile  Val Thr Ile 
    4115                 4120                 4125             


Lys Asp  Thr Gln Asp Phe Ile  Arg Asp Leu Glu Asp  Pro Gly Ile 
    4130                 4135                 4140             


Asp Pro  Ser Val Val Lys Gln  Gln Gln Glu Ala Ala  Glu Thr Ile 
    4145                 4150                 4155             


Arg Glu  Glu Ile Asp Gly Leu  Gln Glu Glu Leu Asp  Ile Val Ile 
    4160                 4165                 4170             


Asn Leu  Gly Ser Glu Leu Ile  Ala Ala Cys Gly Glu  Pro Asp Lys 
    4175                 4180                 4185             


Pro Ile  Val Lys Lys Ser Ile  Asp Glu Leu Asn Ser  Ala Trp Asp 
    4190                 4195                 4200             


Ser Leu  Asn Lys Ala Trp Lys  Asp Arg Ile Asp Lys  Leu Glu Glu 
    4205                 4210                 4215             


Ala Met  Gln Ala Ala Val Gln  Tyr Gln Asp Gly Leu  Gln Ala Val 
    4220                 4225                 4230             


Phe Asp  Trp Val Asp Ile Ala  Gly Gly Lys Leu Ala  Ser Met Ser 
    4235                 4240                 4245             


Pro Ile  Gly Thr Asp Leu Glu  Thr Val Lys Gln Gln  Ile Glu Glu 
    4250                 4255                 4260             


Leu Lys  Gln Phe Lys Ser Glu  Ala Tyr Gln Gln Gln  Ile Glu Met 
    4265                 4270                 4275             


Glu Arg  Leu Asn His Gln Ala  Glu Leu Leu Leu Lys  Lys Val Thr 
    4280                 4285                 4290             


Glu Glu  Ser Asp Lys His Thr  Val Gln Asp Pro Leu  Met Glu Leu 
    4295                 4300                 4305             


Lys Leu  Ile Trp Asp Ser Leu  Glu Glu Arg Ile Ile  Asn Arg Gln 
    4310                 4315                 4320             


His Lys  Leu Glu Gly Ala Leu  Leu Ala Leu Gly Gln  Phe Gln His 
    4325                 4330                 4335             


Ala Leu  Asp Glu Leu Leu Ala  Trp Leu Thr His Thr  Glu Gly Leu 
    4340                 4345                 4350             


Leu Ser  Glu Gln Lys Pro Val  Gly Gly Asp Pro Lys  Ala Ile Glu 
    4355                 4360                 4365             


Ile Glu  Leu Ala Lys His His  Val Leu Gln Asn Asp  Val Leu Ala 
    4370                 4375                 4380             


His Gln  Ser Thr Val Glu Ala  Val Asn Lys Ala Gly  Asn Asp Leu 
    4385                 4390                 4395             


Ile Glu  Ser Ser Ala Gly Glu  Glu Ala Ser Asn Leu  Gln Asn Lys 
    4400                 4405                 4410             


Leu Glu  Val Leu Asn Gln Arg  Trp Gln Asn Val Leu  Glu Lys Thr 
    4415                 4420                 4425             


Glu Gln  Arg Lys Gln Gln Leu  Asp Gly Ala Leu Arg  Gln Ala Lys 
    4430                 4435                 4440             


Gly Phe  His Gly Glu Ile Glu  Asp Leu Gln Gln Trp  Leu Thr Asp 
    4445                 4450                 4455             


Thr Glu  Arg His Leu Leu Ala  Ser Lys Pro Leu Gly  Gly Leu Pro 
    4460                 4465                 4470             


Glu Thr  Ala Lys Glu Gln Leu  Asn Val His Met Glu  Val Cys Ala 
    4475                 4480                 4485             


Ala Phe  Glu Ala Lys Glu Glu  Thr Tyr Lys Ser Leu  Met Gln Lys 
    4490                 4495                 4500             


Gly Gln  Gln Met Leu Ala Arg  Cys Pro Lys Ser Ala  Glu Thr Asn 
    4505                 4510                 4515             


Ile Asp  Gln Asp Ile Asn Asn  Leu Lys Glu Lys Trp  Glu Ser Val 
    4520                 4525                 4530             


Glu Thr  Lys Leu Asn Glu Arg  Lys Thr Lys Leu Glu  Glu Ala Leu 
    4535                 4540                 4545             


Asn Leu  Ala Met Glu Phe His  Asn Ser Leu Gln Asp  Phe Ile Asn 
    4550                 4555                 4560             


Trp Leu  Thr Gln Ala Glu Gln  Thr Leu Asn Val Ala  Ser Arg Pro 
    4565                 4570                 4575             


Ser Leu  Ile Leu Asp Thr Val  Leu Phe Gln Ile Asp  Glu His Lys 
    4580                 4585                 4590             


Val Phe  Ala Asn Glu Val Asn  Ser His Arg Glu Gln  Ile Ile Glu 
    4595                 4600                 4605             


Leu Asp  Lys Thr Gly Thr His  Leu Lys Tyr Phe Ser  Gln Lys Gln 
    4610                 4615                 4620             


Asp Val  Val Leu Ile Lys Asn  Leu Leu Ile Ser Val  Gln Ser Arg 
    4625                 4630                 4635             


Trp Glu  Lys Val Val Gln Arg  Leu Val Glu Arg Gly  Arg Ser Leu 
    4640                 4645                 4650             


Asp Asp  Ala Arg Lys Arg Ala  Lys Gln Phe His Glu  Ala Trp Ser 
    4655                 4660                 4665             


Lys Leu  Met Glu Trp Leu Glu  Glu Ser Glu Lys Ser  Leu Asp Ser 
    4670                 4675                 4680             


Glu Leu  Glu Ile Ala Asn Asp  Pro Asp Lys Ile Lys  Thr Gln Leu 
    4685                 4690                 4695             


Ala Gln  His Lys Glu Phe Gln  Lys Ser Leu Gly Ala  Lys His Ser 
    4700                 4705                 4710             


Val Tyr  Asp Thr Thr Asn Arg  Thr Gly Arg Ser Leu  Lys Glu Lys 
    4715                 4720                 4725             


Thr Ser  Leu Ala Asp Asp Asn  Leu Lys Leu Asp Asp  Met Leu Ser 
    4730                 4735                 4740             


Glu Leu  Arg Asp Lys Trp Asp  Thr Ile Cys Gly Lys  Ser Val Glu 
    4745                 4750                 4755             


Arg Gln  Asn Lys Leu Glu Glu  Ala Leu Leu Phe Ser  Gly Gln Phe 
    4760                 4765                 4770             


Thr Asp  Ala Leu Gln Ala Leu  Ile Asp Trp Leu Tyr  Arg Val Glu 
    4775                 4780                 4785             


Pro Gln  Leu Ala Glu Asp Gln  Pro Val His Gly Asp  Ile Asp Leu 
    4790                 4795                 4800             


Val Met  Asn Leu Ile Asp Asn  His Lys Ala Phe Gln  Lys Glu Leu 
    4805                 4810                 4815             


Gly Lys  Arg Thr Ser Ser Val  Gln Ala Leu Lys Arg  Ser Ala Arg 
    4820                 4825                 4830             


Glu Leu  Ile Glu Gly Ser Arg  Asp Asp Ser Ser Trp  Val Lys Val 
    4835                 4840                 4845             


Gln Met  Gln Glu Leu Ser Thr  Arg Trp Glu Thr Val  Cys Ala Leu 
    4850                 4855                 4860             


Ser Ile  Ser Lys Gln Thr Arg  Leu Glu Ala Ala Leu  Arg Gln Ala 
    4865                 4870                 4875             


Glu Glu  Phe His Ser Val Val  His Ala Leu Leu Glu  Trp Leu Ala 
    4880                 4885                 4890             


Glu Ala  Glu Gln Thr Leu Arg  Phe His Gly Val Leu  Pro Asp Asp 
    4895                 4900                 4905             


Glu Asp  Ala Leu Arg Thr Leu  Ile Asp Gln His Lys  Glu Phe Met 
    4910                 4915                 4920             


Lys Lys  Leu Glu Glu Lys Arg  Ala Glu Leu Asn Lys  Ala Thr Thr 
    4925                 4930                 4935             


Met Gly  Asp Thr Val Leu Ala  Ile Cys His Pro Asp  Ser Ile Thr 
    4940                 4945                 4950             


Thr Ile  Lys His Trp Ile Thr  Ile Ile Arg Ala Arg  Phe Glu Glu 
    4955                 4960                 4965             


Val Leu  Ala Trp Ala Lys Gln  His Gln Gln Arg Leu  Ala Ser Ala 
    4970                 4975                 4980             


Leu Ala  Gly Leu Ile Ala Lys  Gln Glu Leu Leu Glu  Ala Leu Leu 
    4985                 4990                 4995             


Ala Trp  Leu Gln Trp Ala Glu  Thr Thr Leu Thr Asp  Lys Asp Lys 
    5000                 5005                 5010             


Glu Val  Ile Pro Gln Glu Ile  Glu Glu Val Lys Ala  Leu Ile Ala 
    5015                 5020                 5025             


Glu His  Gln Thr Phe Met Glu  Glu Met Thr Arg Lys  Gln Pro Asp 
    5030                 5035                 5040             


Val Asp  Lys Val Thr Lys Thr  Tyr Lys Arg Arg Ala  Ala Asp Pro 
    5045                 5050                 5055             


Ser Ser  Leu Gln Ser His Ile  Pro Val Leu Asp Lys  Gly Arg Ala 
    5060                 5065                 5070             


Gly Arg  Lys Arg Phe Pro Ala  Ser Ser Leu Tyr Pro  Ser Gly Ser 
    5075                 5080                 5085             


Gln Thr  Gln Ile Glu Thr Lys  Asn Pro Arg Val Asn  Leu Leu Val 
    5090                 5095                 5100             


Ser Lys  Trp Gln Gln Val Trp  Leu Leu Ala Leu Glu  Arg Arg Arg 
    5105                 5110                 5115             


Lys Leu  Asn Asp Ala Leu Asp  Arg Leu Glu Glu Leu  Arg Glu Phe 
    5120                 5125                 5130             


Ala Asn  Phe Asp Phe Asp Ile  Trp Arg Lys Lys Tyr  Met Arg Trp 
    5135                 5140                 5145             


Met Asn  His Lys Lys Ser Arg  Val Met Asp Phe Phe  Arg Arg Ile 
    5150                 5155                 5160             


Asp Lys  Asp Gln Asp Gly Lys  Ile Thr Arg Gln Glu  Phe Ile Asp 
    5165                 5170                 5175             


Gly Ile  Leu Ser Ser Lys Phe  Pro Thr Ser Arg Leu  Glu Met Ser 
    5180                 5185                 5190             


Ala Val  Ala Asp Ile Phe Asp  Arg Asp Gly Asp Gly  Tyr Ile Asp 
    5195                 5200                 5205             


Tyr Tyr  Glu Phe Val Ala Ala  Leu His Pro Asn Lys  Asp Ala Tyr 
    5210                 5215                 5220             


Lys Pro  Ile Thr Asp Ala Asp  Lys Ile Glu Asp Glu  Val Thr Arg 
    5225                 5230                 5235             


Gln Val  Ala Lys Cys Lys Cys  Ala Lys Arg Phe Gln  Val Glu Gln 
    5240                 5245                 5250             


Ile Gly  Asp Asn Lys Tyr Arg  Phe Phe Leu Gly Asn  Gln Phe Gly 
    5255                 5260                 5265             


Asp Ser  Gln Gln Leu Arg Leu  Val Arg Ile Leu Arg  Ser Thr Val 
    5270                 5275                 5280             


Met Val  Arg Val Gly Gly Gly  Trp Met Ala Leu Asp  Glu Phe Leu 
    5285                 5290                 5295             


Val Lys  Asn Asp Pro Cys Arg  Ala Lys Gly Arg Thr  Asn Met Glu 
    5300                 5305                 5310             


Leu Arg  Glu Lys Phe Ile Leu  Ala Asp Gly Ala Ser  Gln Gly Met 
    5315                 5320                 5325             


Ala Ala  Phe Arg Pro Arg Gly  Arg Arg Ser Arg Pro  Ser Ser Arg 
    5330                 5335                 5340             


Gly Ala  Ser Pro Asn Arg Ser  Thr Ser Val Ser Ser  Gln Ala Ala 
    5345                 5350                 5355             


Gln Ala  Ala Ser Pro Gln Val  Pro Ala Thr Thr Thr  Pro Lys Ile 
    5360                 5365                 5370             


Leu His  Pro Leu Thr Arg Asn  Tyr Gly Lys Pro Trp  Leu Thr Asn 
    5375                 5380                 5385             


Ser Lys  Met Ser Thr Pro Cys  Lys Ala Ala Glu Cys  Ser Asp Phe 
    5390                 5395                 5400             


Pro Val  Pro Ser Ala Glu Gly  Thr Pro Ile Gln Gly  Ser Lys Leu 
    5405                 5410                 5415             


Arg Leu  Pro Gly Tyr Leu Ser  Gly Lys Gly Phe His  Ser Gly Glu 
    5420                 5425                 5430             


Asp Ser  Gly Leu Ile Thr Thr  Ala Ala Ala Arg Val  Arg Thr Gln 
    5435                 5440                 5445             


Phe Ala  Asp Ser Lys Lys Thr  Pro Ser Arg Pro Gly  Ser Arg Ala 
    5450                 5455                 5460             


Gly Ser  Lys Ala Gly Ser Arg  Ala Ser Ser Arg Arg  Gly Ser Asp 
    5465                 5470                 5475             


Ala Ser  Asp Phe Asp Ile Ser  Glu Ile Gln Ser Val  Cys Ser Asp 
    5480                 5485                 5490             


Val Glu  Thr Val Pro Gln Thr  His Arg Pro Thr Pro  Arg Ala Gly 
    5495                 5500                 5505             


Ser Arg  Pro Ser Thr Ala Lys  Pro Ser Lys Ile Pro  Thr Pro Gln 
    5510                 5515                 5520             


Arg Lys  Ser Pro Ala Ser Lys  Leu Asp Lys Ser Ser  Lys Arg 
    5525                 5530                 5535         


<210>  4464
<211>  1479
<212>  PRT
<213>  Homo Sapiens

<400>  4464

Met Ser Ser Gly Asn Ala Ser Tyr Arg Cys Ser Met Ser Ser Ser Ala 
1               5                   10                  15      


Asp Phe Ser Asp Glu Asp Asp Phe Ser Gln Lys Ser Gly Ser Ala Ser 
            20                  25                  30          


Pro Ala Pro Gly Asp Thr Leu Pro Trp Asn Leu Pro Lys His Glu Arg 
        35                  40                  45              


Ser Lys Arg Lys Ile Gln Gly Gly Ser Val Leu Asp Pro Ala Glu Arg 
    50                  55                  60                  


Ala Val Leu Arg Ile Ala Asp Glu Arg Asp Lys Val Gln Lys Lys Thr 
65                  70                  75                  80  


Phe Thr Lys Trp Ile Asn Gln His Leu Met Lys Val Arg Lys His Val 
                85                  90                  95      


Asn Asp Leu Tyr Glu Asp Leu Arg Asp Gly His Asn Leu Ile Ser Leu 
            100                 105                 110         


Leu Glu Val Leu Ser Gly Asp Thr Leu Pro Arg Glu Lys Gly Arg Met 
        115                 120                 125             


Arg Phe His Arg Leu Gln Asn Val Gln Ile Ala Leu Asp Tyr Leu Lys 
    130                 135                 140                 


Arg Arg Gln Val Lys Leu Val Asn Ile Arg Asn Asp Asp Ile Thr Asp 
145                 150                 155                 160 


Gly Asn Pro Lys Leu Thr Leu Gly Leu Ile Trp Thr Ile Ile Leu His 
                165                 170                 175     


Phe Gln Ile Ser Asp Ile His Val Thr Gly Glu Ser Glu Asp Met Ser 
            180                 185                 190         


Ala Lys Glu Arg Leu Leu Leu Trp Thr Gln Gln Ala Thr Glu Gly Tyr 
        195                 200                 205             


Ala Gly Ile Arg Cys Glu Asn Phe Thr Thr Cys Trp Arg Asp Gly Lys 
    210                 215                 220                 


Leu Phe Asn Ala Ile Ile His Lys Tyr Arg Pro Asp Leu Ile Asp Met 
225                 230                 235                 240 


Asn Thr Val Ala Val Gln Ser Asn Leu Ala Asn Leu Glu His Ala Phe 
                245                 250                 255     


Tyr Val Ala Glu Lys Ile Gly Val Ile Arg Leu Leu Asp Pro Glu Asp 
            260                 265                 270         


Val Asp Val Ser Ser Pro Asp Glu Lys Ser Val Ile Thr Tyr Val Ser 
        275                 280                 285             


Ser Leu Tyr Asp Ala Phe Pro Lys Val Pro Glu Gly Gly Glu Gly Ile 
    290                 295                 300                 


Gly Ala Asn Asp Val Glu Val Lys Trp Ile Glu Tyr Gln Asn Met Val 
305                 310                 315                 320 


Asn Tyr Leu Ile Gln Trp Ile Arg His His Val Thr Thr Met Ser Glu 
                325                 330                 335     


Arg Thr Phe Pro Asn Asn Pro Val Glu Leu Lys Ala Leu Tyr Asn Gln 
            340                 345                 350         


Tyr Leu Gln Phe Lys Glu Thr Glu Ile Pro Pro Lys Glu Thr Glu Lys 
        355                 360                 365             


Ser Lys Ile Lys Arg Leu Tyr Lys Leu Leu Glu Ile Trp Ile Glu Phe 
    370                 375                 380                 


Gly Arg Ile Lys Leu Leu Gln Gly Tyr His Pro Asn Asp Ile Glu Lys 
385                 390                 395                 400 


Glu Trp Gly Lys Leu Ile Ile Ala Met Leu Glu Arg Glu Lys Ala Leu 
                405                 410                 415     


Arg Pro Glu Val Glu Arg Leu Glu Met Leu Gln Gln Ile Ala Asn Arg 
            420                 425                 430         


Val Gln Arg Asp Ser Val Ile Cys Glu Asp Lys Leu Ile Leu Ala Gly 
        435                 440                 445             


Asn Ala Leu Gln Ser Asp Ser Lys Arg Leu Glu Ser Gly Val Gln Phe 
    450                 455                 460                 


Gln Asn Glu Ala Glu Ile Ala Gly Tyr Ile Leu Glu Cys Glu Asn Leu 
465                 470                 475                 480 


Leu Arg Gln His Val Ile Asp Val Gln Ile Leu Ile Asp Gly Lys Tyr 
                485                 490                 495     


Tyr Gln Ala Asp Gln Leu Val Gln Arg Val Ala Lys Leu Arg Asp Glu 
            500                 505                 510         


Ile Met Ala Leu Arg Asn Glu Cys Ser Ser Val Tyr Ser Lys Gly Arg 
        515                 520                 525             


Ile Leu Thr Thr Glu Gln Thr Lys Leu Met Ile Ser Gly Ile Thr Gln 
    530                 535                 540                 


Ser Leu Asn Ser Gly Phe Ala Gln Thr Leu His Pro Ser Leu Thr Ser 
545                 550                 555                 560 


Gly Leu Thr Gln Ser Leu Thr Pro Ser Leu Thr Ser Ser Ser Met Thr 
                565                 570                 575     


Ser Gly Leu Ser Ser Gly Met Thr Ser Arg Leu Thr Pro Ser Val Thr 
            580                 585                 590         


Pro Ala Tyr Thr Pro Gly Phe Pro Ser Gly Leu Val Pro Asn Phe Ser 
        595                 600                 605             


Ser Gly Val Glu Pro Asn Ser Leu Gln Thr Leu Lys Leu Met Gln Ile 
    610                 615                 620                 


Arg Lys Pro Leu Leu Lys Ser Ser Leu Leu Asp Gln Asn Leu Thr Glu 
625                 630                 635                 640 


Glu Glu Ile Asn Met Lys Phe Val Gln Asp Leu Leu Asn Trp Val Asp 
                645                 650                 655     


Glu Met Gln Val Gln Leu Asp Arg Thr Glu Trp Gly Ser Asp Leu Pro 
            660                 665                 670         


Ser Val Glu Ser His Leu Glu Asn His Lys Asn Val His Arg Ala Ile 
        675                 680                 685             


Glu Glu Phe Glu Ser Ser Leu Lys Glu Ala Lys Ile Ser Glu Ile Gln 
    690                 695                 700                 


Met Thr Ala Pro Leu Lys Leu Thr Tyr Ala Glu Lys Leu His Arg Leu 
705                 710                 715                 720 


Glu Ser Gln Tyr Ala Lys Leu Leu Asn Thr Ser Arg Asn Gln Glu Arg 
                725                 730                 735     


His Leu Asp Thr Leu His Asn Phe Val Ser Arg Ala Thr Asn Glu Leu 
            740                 745                 750         


Ile Trp Leu Asn Glu Lys Glu Glu Glu Glu Val Ala Tyr Asp Trp Ser 
        755                 760                 765             


Glu Arg Asn Thr Asn Ile Ala Arg Lys Lys Asp Tyr His Ala Glu Leu 
    770                 775                 780                 


Met Arg Glu Leu Asp Gln Lys Glu Glu Asn Ile Lys Ser Val Gln Glu 
785                 790                 795                 800 


Ile Ala Glu Gln Leu Leu Leu Glu Asn His Pro Ala Arg Leu Thr Ile 
                805                 810                 815     


Glu Ala Tyr Arg Ala Ala Met Gln Thr Gln Trp Ser Trp Ile Leu Gln 
            820                 825                 830         


Leu Cys Gln Cys Val Glu Gln His Ile Lys Glu Asn Thr Ala Tyr Phe 
        835                 840                 845             


Glu Phe Phe Asn Asp Ala Lys Glu Ala Thr Asp Tyr Leu Arg Asn Leu 
    850                 855                 860                 


Lys Asp Ala Ile Gln Arg Lys Tyr Ser Cys Asp Arg Ser Ser Ser Ile 
865                 870                 875                 880 


His Lys Leu Glu Asp Leu Val Gln Glu Ser Met Glu Glu Lys Glu Glu 
                885                 890                 895     


Leu Leu Gln Tyr Lys Ser Thr Ile Ala Asn Leu Met Gly Lys Ala Lys 
            900                 905                 910         


Thr Ile Ile Gln Leu Lys Pro Arg Asn Ser Asp Cys Pro Leu Lys Thr 
        915                 920                 925             


Ser Ile Pro Ile Lys Ala Ile Cys Asp Tyr Arg Gln Ile Glu Ile Thr 
    930                 935                 940                 


Ile Tyr Lys Asp Asp Glu Cys Val Leu Ala Asn Asn Ser His Arg Ala 
945                 950                 955                 960 


Lys Trp Lys Val Ile Ser Pro Thr Gly Asn Glu Ala Met Val Pro Ser 
                965                 970                 975     


Val Cys Phe Thr Val Pro Pro Pro Asn Lys Glu Ala Val Asp Leu Ala 
            980                 985                 990         


Asn Arg Ile Glu Gln Gln Tyr Gln  Asn Val Leu Thr Leu  Trp His Glu 
        995                 1000                 1005             


Ser His  Ile Asn Met Lys Ser  Val Val Ser Trp His  Tyr Leu Ile 
    1010                 1015                 1020             


Asn Glu  Ile Asp Arg Ile Arg  Ala Ser Asn Val Ala  Ser Ile Lys 
    1025                 1030                 1035             


Thr Met  Leu Pro Gly Glu His  Gln Gln Val Leu Ser  Asn Leu Gln 
    1040                 1045                 1050             


Ser Arg  Phe Glu Asp Phe Leu  Glu Asp Ser Gln Glu  Ser Gln Val 
    1055                 1060                 1065             


Phe Ser  Gly Ser Asp Ile Thr  Gln Leu Glu Lys Glu  Val Asn Val 
    1070                 1075                 1080             


Cys Lys  Gln Tyr Tyr Gln Glu  Leu Leu Lys Ser Ala  Glu Arg Glu 
    1085                 1090                 1095             


Glu Gln  Glu Glu Ser Val Tyr  Asn Leu Tyr Ile Ser  Glu Val Arg 
    1100                 1105                 1110             


Asn Ile  Arg Leu Arg Leu Glu  Asn Cys Glu Asp Arg  Leu Ile Arg 
    1115                 1120                 1125             


Gln Ile  Arg Thr Pro Leu Glu  Arg Asp Asp Leu His  Glu Ser Val 
    1130                 1135                 1140             


Phe Arg  Ile Thr Glu Gln Glu  Lys Leu Lys Lys Glu  Leu Glu Arg 
    1145                 1150                 1155             


Leu Lys  Asp Asp Leu Gly Thr  Ile Thr Asn Lys Cys  Glu Glu Phe 
    1160                 1165                 1170             


Phe Ser  Gln Ala Ala Ala Ser  Ser Ser Val Pro Thr  Leu Arg Ser 
    1175                 1180                 1185             


Glu Leu  Asn Val Val Leu Gln  Asn Met Asn Gln Val  Tyr Ser Met 
    1190                 1195                 1200             


Ser Ser  Thr Tyr Ile Asp Lys  Leu Lys Thr Val Asn  Leu Val Leu 
    1205                 1210                 1215             


Lys Asn  Thr Gln Ala Ala Glu  Ala Leu Val Lys Leu  Tyr Glu Thr 
    1220                 1225                 1230             


Lys Leu  Cys Glu Glu Glu Ala  Val Ile Ala Asp Lys  Asn Asn Ile 
    1235                 1240                 1245             


Glu Asn  Leu Ile Ser Thr Leu  Lys Gln Trp Arg Ser  Glu Val Asp 
    1250                 1255                 1260             


Glu Lys  Arg Gln Val Phe His  Ala Leu Glu Asp Glu  Leu Gln Lys 
    1265                 1270                 1275             


Ala Lys  Ala Ile Ser Asp Glu  Met Phe Lys Thr Tyr  Lys Glu Arg 
    1280                 1285                 1290             


Asp Leu  Asp Phe Asp Trp His  Lys Glu Lys Ala Asp  Gln Leu Val 
    1295                 1300                 1305             


Glu Arg  Trp Gln Asn Val His  Val Gln Ile Asp Asn  Arg Leu Arg 
    1310                 1315                 1320             


Asp Leu  Glu Gly Ile Gly Lys  Ser Leu Lys Tyr Tyr  Arg Asp Thr 
    1325                 1330                 1335             


Tyr His  Pro Leu Asp Asp Trp  Ile Gln Gln Val Glu  Thr Thr Gln 
    1340                 1345                 1350             


Arg Lys  Ile Gln Glu Asn Gln  Pro Glu Asn Ser Lys  Thr Leu Ala 
    1355                 1360                 1365             


Thr Gln  Leu Asn Gln Gln Lys  Met Leu Val Ser Glu  Ile Glu Met 
    1370                 1375                 1380             


Lys Gln  Ser Lys Met Asp Glu  Cys Gln Lys Tyr Ala  Glu Gln Tyr 
    1385                 1390                 1395             


Ser Ala  Thr Val Lys Asp Tyr  Glu Leu Gln Thr Met  Thr Tyr Arg 
    1400                 1405                 1410             


Ala Met  Val Asp Ser Gln Gln  Lys Ser Pro Val Lys  Arg Arg Arg 
    1415                 1420                 1425             


Met Gln  Ser Ser Ala Asp Leu  Ile Ile Gln Glu Phe  Met Asp Leu 
    1430                 1435                 1440             


Arg Thr  Arg Tyr Thr Ala Leu  Val Thr Leu Met Thr  Gln Tyr Ile 
    1445                 1450                 1455             


Lys Phe  Ala Gly Asp Ser Leu  Lys Arg Leu Glu Glu  Glu Glu Lys 
    1460                 1465                 1470             


Ser Leu  Glu Glu Glu Lys 
    1475                 


<210>  4465
<211>  7
<212>  PRT
<213>  Homo Sapiens

<400>  4465

Met Val Asp Thr Glu Glu Leu 
1               5           


<210>  4466
<211>  177
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4466

Xaa Gln Leu Asn Gln Gln Lys Met Leu Val Ser Glu Ile Glu Met Lys 
1               5                   10                  15      


Gln Ser Lys Met Asp Glu Cys Gln Lys Tyr Ala Glu Gln Tyr Ser Ala 
            20                  25                  30          


Thr Val Lys Asp Tyr Glu Leu Gln Thr Met Thr Tyr Arg Ala Met Val 
        35                  40                  45              


Asp Ser Gln Gln Lys Ser Pro Val Lys Arg Arg Arg Met Gln Ser Ser 
    50                  55                  60                  


Ala Asp Leu Ile Ile Gln Glu Phe Met Asp Leu Arg Thr Arg Tyr Thr 
65                  70                  75                  80  


Ala Leu Val Thr Leu Met Thr Gln Tyr Ile Lys Phe Ala Gly Asp Ser 
                85                  90                  95      


Leu Lys Arg Leu Glu Glu Glu Glu Ile Ala Lys Asn Lys Gln Tyr Asp 
            100                 105                 110         


Met His Thr Glu Val Thr Thr Leu Lys Gln Glu Lys Asn Pro Val Pro 
        115                 120                 125             


Ser Ala Glu Glu Trp Met Leu Glu Gly Cys Arg Ala Ser Gly Gly Leu 
    130                 135                 140                 


Lys Lys Gly Asp Phe Leu Lys Lys Gly Leu Glu Pro Glu Thr Phe Gln 
145                 150                 155                 160 


Asn Phe Asp Gly Asp His Ala Cys Ser Val Arg Asp Asp Glu Phe Lys 
                165                 170                 175     


Phe 
    


<210>  4467
<211>  259
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4467

Xaa Thr Arg Gln Val Ala Lys Cys Lys Cys Ala Lys Arg Phe Gln Val 
1               5                   10                  15      


Glu Gln Ile Gly Asp Asn Lys Tyr Arg Phe Gly Asp Ser Gln Gln Leu 
            20                  25                  30          


Arg Leu Val Arg Ile Leu Arg Ser Thr Val Met Val Arg Val Gly Gly 
        35                  40                  45              


Gly Trp Met Ala Leu Asp Glu Phe Leu Val Lys Asn Asp Pro Cys Arg 
    50                  55                  60                  


Ala Lys Gly Arg Thr Asn Met Glu Leu Arg Glu Lys Phe Ile Leu Ala 
65                  70                  75                  80  


Asp Gly Ala Ser Gln Gly Met Ala Ala Phe Arg Pro Arg Gly Arg Arg 
                85                  90                  95      


Ser Arg Pro Ser Ser Arg Gly Ala Ser Pro Asn Arg Ser Thr Ser Val 
            100                 105                 110         


Ser Ser Gln Ala Ala Gln Ala Ala Ser Pro Gln Val Pro Ala Thr Thr 
        115                 120                 125             


Thr Pro Lys Gly Thr Pro Ile Gln Gly Ser Lys Leu Arg Leu Pro Gly 
    130                 135                 140                 


Tyr Leu Ser Gly Lys Gly Phe His Ser Gly Glu Asp Ser Gly Leu Ile 
145                 150                 155                 160 


Thr Thr Ala Ala Ala Arg Val Arg Thr Gln Phe Ala Asp Ser Lys Lys 
                165                 170                 175     


Thr Pro Ser Arg Pro Gly Ser Arg Ala Gly Ser Lys Ala Gly Ser Arg 
            180                 185                 190         


Ala Ser Ser Arg Arg Gly Ser Asp Ala Ser Asp Phe Asp Ile Ser Glu 
        195                 200                 205             


Ile Gln Ser Val Cys Ser Asp Val Glu Thr Val Pro Gln Thr His Arg 
    210                 215                 220                 


Pro Thr Pro Arg Ala Gly Ser Arg Pro Ser Thr Ala Lys Pro Ser Lys 
225                 230                 235                 240 


Ile Pro Thr Pro Gln Arg Lys Ser Pro Ala Ser Lys Leu Asp Lys Ser 
                245                 250                 255     


Ser Lys Arg 
            


<210>  4468
<211>  448
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4468

Xaa Val Val Thr Thr Ala Ile Lys Glu Glu Thr Glu Lys Val Ala Ala 
1               5                   10                  15      


Val Lys Gln Leu Glu Glu Ser Lys Thr Lys Ile Glu Asn Leu Leu Asp 
            20                  25                  30          


Trp Leu Ser Asn Val Asp Lys Asp Ser Glu Arg Ala Gly Thr Lys His 
        35                  40                  45              


Lys Gln Val Ile Glu Gln Asn Gly Thr His Phe Gln Glu Gly Asp Gly 
    50                  55                  60                  


Lys Ser Ala Ile Gly Glu Glu Asp Glu Val Asn Gly Asn Leu Leu Glu 
65                  70                  75                  80  


Thr Asp Val Asp Gly Gln Val Gly Thr Thr Gln Glu Asn Leu Asn Gln 
                85                  90                  95      


Gln Tyr Gln Lys Val Lys Ala Gln His Glu Lys Ile Ile Ser Gln His 
            100                 105                 110         


Gln Ala Val Ile Ile Ala Thr Gln Ser Ala Gln Val Leu Leu Glu Lys 
        115                 120                 125             


Gln Gly Gln Tyr Leu Ser Pro Glu Glu Lys Glu Lys Leu Gln Lys Asn 
    130                 135                 140                 


Met Lys Glu Leu Lys Val His Tyr Glu Thr Ala Leu Ala Glu Ser Glu 
145                 150                 155                 160 


Lys Lys Met Lys Leu Thr His Ser Leu Gln Glu Glu Leu Glu Lys Phe 
                165                 170                 175     


Asp Ala Asp Tyr Thr Glu Phe Glu His Trp Leu Gln Gln Ser Glu Gln 
            180                 185                 190         


Glu Leu Glu Asn Leu Glu Ala Gly Ala Asp Asp Ile Asn Gly Leu Met 
        195                 200                 205             


Thr Lys Leu Lys Arg Gln Lys Ser Phe Ser Glu Asp Val Ile Ser His 
    210                 215                 220                 


Lys Gly Asp Leu Arg Tyr Ile Thr Ile Ser Gly Asn Arg Val Leu Glu 
225                 230                 235                 240 


Ala Ala Lys Ser Cys Ser Lys Arg Asp Gly Gly Lys Val Asp Thr Ser 
                245                 250                 255     


Ala Thr His Arg Glu Val Gln Arg Lys Leu Asp His Ala Thr Asp Arg 
            260                 265                 270         


Phe Arg Ser Leu Tyr Ser Lys Cys Asn Val Leu Gly Asn Asn Leu Lys 
        275                 280                 285             


Asp Leu Val Asp Lys Tyr Gln His Tyr Glu Asp Ala Ser Cys Gly Leu 
    290                 295                 300                 


Leu Ala Gly Leu Gln Ala Cys Glu Ala Thr Ala Ser Lys His Leu Ser 
305                 310                 315                 320 


Glu Pro Ile Ala Val Asp Pro Lys Asn Leu Gln Arg Gln Leu Glu Glu 
                325                 330                 335     


Thr Lys Ala Leu Gln Gly Gln Ile Ser Ser Gln Gln Val Ala Val Glu 
            340                 345                 350         


Lys Leu Lys Lys Thr Ala Glu Val Leu Leu Asp Ala Arg Gly Ser Leu 
        355                 360                 365             


Leu Pro Ala Lys Asn Asp Ile Gln Lys Thr Leu Asp Asp Ile Val Gly 
    370                 375                 380                 


Arg Tyr Glu Asp Leu Ser Lys Ser Val Asn Glu Arg Asn Glu Lys Leu 
385                 390                 395                 400 


Gln Ile Thr Leu Thr Arg Ser Leu Ser Val Gln Asp Gly Leu Asp Glu 
                405                 410                 415     


Met Leu Asp Trp Met Gly Asn Val Glu Ser Ser Leu Lys Glu Gln Asp 
            420                 425                 430         


Val Gly Thr Gly Tyr Cys Arg Ser Ser Glu Gln Tyr Lys Cys His Glu 
        435                 440                 445             


<210>  4469
<211>  43
<212>  PRT
<213>  Homo Sapiens

<400>  4469

Met Gly Phe Cys Leu Ala Leu Ala Trp Thr Leu Leu Val Gly Ala Trp 
1               5                   10                  15      


Thr Pro Leu Gly Ala Gln Asn Pro Ile Ser Trp Glu Val Gln Arg Phe 
            20                  25                  30          


Asp Gly Trp Tyr Asn Asn Leu Met Glu His Arg 
        35                  40              


<210>  4470
<211>  1551
<212>  PRT
<213>  Homo Sapiens

<400>  4470

Met Gly Phe Cys Leu Ala Leu Ala Trp Thr Leu Leu Val Gly Ala Trp 
1               5                   10                  15      


Thr Pro Leu Gly Ala Gln Asn Pro Ile Ser Trp Glu Val Gln Arg Phe 
            20                  25                  30          


Asp Gly Trp Tyr Asn Asn Leu Met Glu His Arg Trp Gly Ser Lys Gly 
        35                  40                  45              


Ser Arg Leu Gln Arg Leu Val Pro Ala Ser Tyr Ala Asp Gly Val Tyr 
    50                  55                  60                  


Gln Pro Leu Gly Glu Pro His Leu Pro Asn Pro Arg Asp Leu Ser Asn 
65                  70                  75                  80  


Thr Ile Ser Arg Gly Pro Ala Gly Leu Ala Ser Leu Arg Asn Arg Thr 
                85                  90                  95      


Val Leu Gly Val Phe Phe Gly Tyr His Val Leu Ser Asp Leu Val Ser 
            100                 105                 110         


Val Glu Thr Pro Gly Cys Pro Ala Glu Phe Leu Asn Ile Arg Ile Pro 
        115                 120                 125             


Pro Gly Asp Pro Met Phe Asp Pro Asp Gln Arg Gly Asp Val Val Leu 
    130                 135                 140                 


Pro Phe Gln Arg Ser Arg Trp Asp Pro Glu Thr Gly Arg Ser Pro Ser 
145                 150                 155                 160 


Asn Pro Arg Asp Pro Ala Asn Gln Val Thr Gly Trp Leu Asp Gly Ser 
                165                 170                 175     


Ala Ile Tyr Gly Ser Ser His Ser Trp Ser Asp Ala Leu Arg Ser Phe 
            180                 185                 190         


Ser Arg Gly Gln Leu Ala Ser Gly Pro Asp Pro Ala Phe Pro Arg Asp 
        195                 200                 205             


Ser Gln Asn Pro Leu Leu Met Trp Ala Ala Pro Asp Pro Ala Thr Gly 
    210                 215                 220                 


Gln Asn Gly Pro Arg Gly Leu Tyr Ala Phe Gly Ala Glu Arg Gly Asn 
225                 230                 235                 240 


Arg Glu Pro Phe Leu Gln Ala Leu Gly Leu Leu Trp Phe Arg Tyr His 
                245                 250                 255     


Asn Leu Trp Ala Gln Arg Leu Ala Arg Gln His Pro Asp Trp Glu Asp 
            260                 265                 270         


Glu Glu Leu Phe Gln His Ala Arg Lys Arg Val Ile Ala Thr Tyr Gln 
        275                 280                 285             


Asn Ile Ala Val Tyr Glu Trp Leu Pro Ser Phe Leu Gln Lys Thr Leu 
    290                 295                 300                 


Pro Glu Tyr Thr Gly Tyr Arg Pro Phe Leu Asp Pro Ser Ile Ser Ser 
305                 310                 315                 320 


Glu Phe Val Ala Ala Ser Glu Gln Phe Leu Ser Thr Met Val Pro Pro 
                325                 330                 335     


Gly Val Tyr Met Arg Asn Ala Ser Cys His Phe Gln Gly Val Ile Asn 
            340                 345                 350         


Arg Asn Ser Ser Val Ser Arg Ala Leu Arg Val Cys Asn Ser Tyr Trp 
        355                 360                 365             


Ser Arg Glu His Pro Ser Leu Gln Ser Ala Glu Asp Val Asp Ala Leu 
    370                 375                 380                 


Leu Leu Gly Met Ala Ser Gln Ile Ala Glu Arg Glu Asp His Val Leu 
385                 390                 395                 400 


Val Glu Asp Val Arg Asp Phe Trp Pro Gly Pro Leu Lys Phe Ser Arg 
                405                 410                 415     


Thr Asp His Leu Ala Ser Cys Leu Gln Arg Gly Arg Asp Leu Gly Leu 
            420                 425                 430         


Pro Ser Tyr Thr Lys Ala Arg Ala Ala Leu Gly Leu Ser Pro Ile Thr 
        435                 440                 445             


Arg Trp Gln Asp Ile Asn Pro Ala Leu Ser Arg Ser Asn Asp Thr Val 
    450                 455                 460                 


Leu Glu Ala Thr Ala Ala Leu Tyr Asn Gln Asp Leu Ser Trp Leu Glu 
465                 470                 475                 480 


Leu Leu Pro Gly Gly Leu Leu Glu Ser His Arg Asp Pro Gly Pro Leu 
                485                 490                 495     


Phe Ser Thr Ile Val Leu Glu Gln Phe Val Arg Leu Arg Asp Gly Asp 
            500                 505                 510         


Arg Tyr Trp Phe Glu Asn Thr Arg Asn Gly Leu Phe Ser Lys Lys Glu 
        515                 520                 525             


Ile Glu Glu Ile Arg Asn Thr Thr Leu Gln Asp Val Leu Val Ala Val 
    530                 535                 540                 


Ile Asn Ile Asp Pro Ser Ala Leu Gln Pro Asn Val Phe Val Trp His 
545                 550                 555                 560 


Lys Gly Asp Pro Cys Pro Gln Pro Arg Gln Leu Ser Thr Glu Gly Leu 
                565                 570                 575     


Pro Ala Cys Ala Pro Ser Val Val Arg Asp Tyr Phe Glu Gly Ser Gly 
            580                 585                 590         


Phe Gly Phe Gly Val Thr Ile Gly Thr Leu Cys Cys Phe Pro Leu Val 
        595                 600                 605             


Ser Leu Leu Ser Ala Trp Ile Val Ala Arg Leu Arg Met Arg Asn Phe 
    610                 615                 620                 


Lys Arg Leu Gln Gly Gln Asp Arg Gln Ser Ile Val Ser Glu Lys Leu 
625                 630                 635                 640 


Val Gly Gly Met Glu Ala Leu Glu Trp Gln Gly His Lys Glu Pro Cys 
                645                 650                 655     


Arg Pro Val Leu Val Tyr Leu Gln Pro Gly Gln Ile Arg Val Val Asp 
            660                 665                 670         


Gly Arg Leu Thr Val Leu Arg Thr Ile Gln Leu Gln Pro Pro Gln Lys 
        675                 680                 685             


Val Asn Phe Val Leu Ser Ser Asn Arg Gly Arg Arg Thr Leu Leu Leu 
    690                 695                 700                 


Lys Ile Pro Lys Glu Tyr Asp Leu Val Leu Leu Phe Asn Leu Glu Glu 
705                 710                 715                 720 


Glu Arg Gln Ala Leu Val Glu Asn Leu Arg Gly Ala Leu Lys Glu Ser 
                725                 730                 735     


Gly Leu Ser Ile Gln Glu Trp Glu Leu Arg Glu Gln Glu Leu Met Arg 
            740                 745                 750         


Ala Ala Val Thr Arg Glu Gln Arg Arg His Leu Leu Glu Thr Phe Phe 
        755                 760                 765             


Arg His Leu Phe Ser Gln Val Leu Asp Ile Asn Gln Ala Asp Ala Gly 
    770                 775                 780                 


Thr Leu Pro Leu Asp Ser Ser Gln Lys Val Arg Glu Ala Leu Thr Cys 
785                 790                 795                 800 


Glu Leu Ser Arg Ala Glu Phe Ala Glu Ser Leu Gly Leu Lys Pro Gln 
                805                 810                 815     


Asp Met Phe Val Glu Ser Met Phe Ser Leu Ala Asp Lys Asp Gly Asn 
            820                 825                 830         


Gly Tyr Leu Ser Phe Arg Glu Phe Leu Asp Ile Leu Val Val Phe Met 
        835                 840                 845             


Lys Gly Ser Pro Glu Glu Lys Ser Arg Leu Met Phe Arg Met Tyr Asp 
    850                 855                 860                 


Phe Asp Gly Asn Gly Leu Ile Ser Lys Asp Glu Phe Ile Arg Met Leu 
865                 870                 875                 880 


Arg Ser Phe Ile Glu Ile Ser Asn Asn Cys Leu Ser Lys Ala Gln Leu 
                885                 890                 895     


Ala Glu Val Val Glu Ser Met Phe Arg Glu Ser Gly Phe Gln Asp Lys 
            900                 905                 910         


Glu Glu Leu Thr Trp Glu Asp Phe His Phe Met Leu Arg Asp His Asn 
        915                 920                 925             


Ser Glu Leu Arg Phe Thr Gln Leu Cys Val Lys Gly Val Glu Val Pro 
    930                 935                 940                 


Glu Val Ile Lys Asp Leu Cys Arg Arg Ala Ser Tyr Ile Ser Gln Asp 
945                 950                 955                 960 


Met Ile Cys Pro Ser Pro Arg Val Ser Ala Arg Cys Ser Arg Ser Asp 
                965                 970                 975     


Ile Glu Thr Glu Leu Thr Pro Gln Arg Leu Gln Cys Pro Met Asp Thr 
            980                 985                 990         


Asp Pro Pro Gln Glu Ile Arg Arg  Arg Phe Gly Lys Lys  Val Thr Ser 
        995                 1000                 1005             


Phe Gln  Pro Leu Leu Phe Thr  Glu Ala His Arg Glu  Lys Phe Gln 
    1010                 1015                 1020             


Arg Ser  Cys Leu His Gln Thr  Val Gln Gln Phe Lys  Arg Phe Ile 
    1025                 1030                 1035             


Glu Asn  Tyr Arg Arg His Ile  Gly Cys Val Ala Val  Phe Tyr Ala 
    1040                 1045                 1050             


Ile Ala  Gly Gly Leu Phe Leu  Glu Arg Ala Tyr Tyr  Tyr Ala Phe 
    1055                 1060                 1065             


Ala Ala  His His Thr Gly Ile  Thr Asp Thr Thr Arg  Val Gly Ile 
    1070                 1075                 1080             


Ile Leu  Ser Arg Gly Thr Ala  Ala Ser Ile Ser Phe  Met Phe Ser 
    1085                 1090                 1095             


Tyr Ile  Leu Leu Thr Met Cys  Arg Asn Leu Ile Thr  Phe Leu Arg 
    1100                 1105                 1110             


Glu Thr  Phe Leu Asn Arg Tyr  Val Pro Phe Asp Ala  Ala Val Asp 
    1115                 1120                 1125             


Phe His  Arg Leu Ile Ala Ser  Thr Ala Ile Val Leu  Thr Val Leu 
    1130                 1135                 1140             


His Ser  Val Gly His Val Val  Asn Val Tyr Leu Phe  Ser Ile Ser 
    1145                 1150                 1155             


Pro Leu  Ser Val Leu Ser Cys  Leu Phe Pro Gly Leu  Phe His Asp 
    1160                 1165                 1170             


Asp Gly  Ser Glu Leu Pro Gln  Lys Tyr Tyr Trp Trp  Phe Phe Gln 
    1175                 1180                 1185             


Thr Val  Pro Gly Leu Thr Gly  Val Val Leu Leu Leu  Ile Leu Ala 
    1190                 1195                 1200             


Ile Met  Tyr Val Phe Ala Ser  His His Phe Arg Arg  Arg Ser Phe 
    1205                 1210                 1215             


Arg Gly  Phe Trp Leu Thr His  His Leu Tyr Ile Leu  Leu Tyr Val 
    1220                 1225                 1230             


Leu Leu  Ile Ile His Gly Ser  Phe Ala Leu Ile Gln  Leu Pro Arg 
    1235                 1240                 1245             


Phe His  Ile Phe Phe Leu Val  Pro Ala Ile Ile Tyr  Gly Gly Asp 
    1250                 1255                 1260             


Lys Leu  Val Ser Leu Ser Arg  Lys Lys Val Glu Ile  Ser Val Val 
    1265                 1270                 1275             


Lys Ala  Glu Leu Leu Pro Ser  Gly Val Thr His Leu  Arg Phe Gln 
    1280                 1285                 1290             


Arg Pro  Gln Gly Phe Glu Tyr  Lys Ser Gly Gln Trp  Val Arg Ile 
    1295                 1300                 1305             


Ala Cys  Leu Ala Leu Gly Thr  Thr Glu Tyr His Pro  Phe Thr Leu 
    1310                 1315                 1320             


Thr Ser  Ala Pro His Glu Asp  Thr Leu Ser Leu His  Ile Arg Ala 
    1325                 1330                 1335             


Ala Gly  Pro Trp Thr Thr Arg  Leu Arg Glu Ile Tyr  Ser Ala Pro 
    1340                 1345                 1350             


Thr Gly  Asp Arg Cys Ala Arg  Tyr Pro Lys Leu Tyr  Leu Asp Gly 
    1355                 1360                 1365             


Pro Phe  Gly Glu Gly His Gln  Glu Trp His Lys Phe  Glu Val Ser 
    1370                 1375                 1380             


Val Leu  Val Gly Gly Gly Ile  Gly Val Thr Pro Phe  Ala Ser Ile 
    1385                 1390                 1395             


Leu Lys  Asp Leu Val Phe Lys  Ser Ser Val Ser Cys  Gln Val Phe 
    1400                 1405                 1410             


Cys Lys  Lys Ile Tyr Phe Ile  Trp Val Thr Arg Thr  Gln Arg Gln 
    1415                 1420                 1425             


Phe Glu  Trp Leu Ala Asp Ile  Ile Arg Glu Val Glu  Glu Asn Asp 
    1430                 1435                 1440             


His Gln  Asp Leu Val Ser Val  His Ile Tyr Ile Thr  Gln Leu Ala 
    1445                 1450                 1455             


Glu Lys  Phe Asp Leu Arg Thr  Thr Met Leu Tyr Ile  Cys Glu Arg 
    1460                 1465                 1470             


His Phe  Gln Lys Val Leu Asn  Arg Ser Leu Phe Thr  Gly Leu Arg 
    1475                 1480                 1485             


Ser Ile  Thr His Phe Gly Arg  Pro Pro Phe Glu Pro  Phe Phe Asn 
    1490                 1495                 1500             


Ser Leu  Gln Glu Val His Pro  Gln Val Arg Lys Ile  Gly Val Phe 
    1505                 1510                 1515             


Ser Cys  Gly Pro Pro Gly Met  Thr Lys Asn Val Glu  Lys Ala Cys 
    1520                 1525                 1530             


Gln Leu  Ile Asn Arg Gln Asp  Arg Thr His Phe Ser  His His Tyr 
    1535                 1540                 1545             


Glu Asn  Phe 
    1550     


<210>  4471
<211>  1551
<212>  PRT
<213>  Homo Sapiens

<400>  4471

Met Gly Phe Cys Leu Ala Leu Ala Trp Thr Leu Leu Val Gly Ala Trp 
1               5                   10                  15      


Thr Pro Leu Gly Ala Gln Asn Pro Ile Ser Trp Glu Val Gln Arg Phe 
            20                  25                  30          


Asp Gly Trp Tyr Asn Asn Leu Met Glu His Arg Trp Gly Ser Lys Gly 
        35                  40                  45              


Ser Arg Leu Gln Arg Leu Val Pro Ala Ser Tyr Ala Asp Gly Val Tyr 
    50                  55                  60                  


Gln Pro Leu Gly Glu Pro His Leu Pro Asn Pro Arg Asp Leu Ser Asn 
65                  70                  75                  80  


Thr Ile Ser Arg Gly Pro Ala Gly Leu Ala Ser Leu Arg Asn Arg Thr 
                85                  90                  95      


Val Leu Gly Val Phe Phe Gly Tyr His Val Leu Ser Asp Leu Val Ser 
            100                 105                 110         


Val Glu Thr Pro Gly Cys Pro Ala Glu Phe Leu Asn Ile Arg Ile Pro 
        115                 120                 125             


Pro Gly Asp Pro Met Phe Asp Pro Asp Gln Arg Gly Asp Val Val Leu 
    130                 135                 140                 


Pro Phe Gln Arg Ser Arg Trp Asp Pro Glu Thr Gly Arg Ser Pro Ser 
145                 150                 155                 160 


Asn Pro Arg Asp Pro Ala Asn Gln Val Thr Gly Trp Leu Asp Gly Ser 
                165                 170                 175     


Ala Ile Tyr Gly Ser Ser His Ser Trp Ser Asp Ala Leu Arg Ser Phe 
            180                 185                 190         


Ser Arg Gly Gln Leu Ala Ser Gly Pro Asp Pro Ala Phe Pro Arg Asp 
        195                 200                 205             


Ser Gln Asn Pro Leu Leu Met Trp Ala Ala Pro Asp Pro Ala Thr Gly 
    210                 215                 220                 


Gln Asn Gly Pro Arg Gly Leu Tyr Ala Phe Gly Ala Glu Arg Gly Asn 
225                 230                 235                 240 


Arg Glu Pro Phe Leu Gln Ala Leu Gly Leu Leu Trp Phe Arg Tyr His 
                245                 250                 255     


Asn Leu Trp Ala Gln Arg Leu Ala Arg Gln His Pro Asp Trp Glu Asp 
            260                 265                 270         


Glu Glu Leu Phe Gln His Ala Arg Lys Arg Val Ile Ala Thr Tyr Gln 
        275                 280                 285             


Asn Ile Ala Val Tyr Glu Trp Leu Pro Ser Phe Leu Gln Lys Thr Leu 
    290                 295                 300                 


Pro Glu Tyr Thr Gly Tyr Arg Pro Phe Leu Asp Pro Ser Ile Ser Ser 
305                 310                 315                 320 


Glu Phe Val Ala Ala Ser Glu Gln Phe Leu Ser Thr Met Val Pro Pro 
                325                 330                 335     


Gly Val Tyr Met Arg Asn Ala Ser Cys His Phe Gln Gly Val Ile Asn 
            340                 345                 350         


Arg Asn Ser Ser Val Ser Arg Ala Leu Arg Val Cys Asn Ser Tyr Trp 
        355                 360                 365             


Ser Arg Glu His Pro Ser Leu Gln Ser Ala Glu Asp Val Asp Ala Leu 
    370                 375                 380                 


Leu Leu Gly Met Ala Ser Gln Ile Ala Glu Arg Glu Asp His Val Leu 
385                 390                 395                 400 


Val Glu Asp Val Arg Asp Phe Trp Pro Gly Pro Leu Lys Phe Ser Arg 
                405                 410                 415     


Thr Asp His Leu Ala Ser Cys Leu Gln Arg Gly Arg Asp Leu Gly Leu 
            420                 425                 430         


Pro Ser Tyr Thr Lys Ala Arg Ala Ala Leu Gly Leu Ser Pro Ile Thr 
        435                 440                 445             


Arg Trp Gln Asp Ile Asn Pro Ala Leu Ser Arg Ser Asn Asp Thr Val 
    450                 455                 460                 


Leu Glu Ala Thr Ala Ala Leu Tyr Asn Gln Asp Leu Ser Trp Leu Glu 
465                 470                 475                 480 


Leu Leu Pro Gly Gly Leu Leu Glu Ser His Arg Asp Pro Gly Pro Leu 
                485                 490                 495     


Phe Ser Thr Ile Val Leu Glu Gln Phe Val Arg Leu Arg Asp Gly Asp 
            500                 505                 510         


Arg Tyr Trp Phe Glu Asn Thr Arg Asn Gly Leu Phe Ser Lys Lys Glu 
        515                 520                 525             


Ile Glu Glu Ile Arg Asn Thr Thr Leu Gln Asp Val Leu Val Ala Val 
    530                 535                 540                 


Ile Asn Ile Asp Pro Ser Ala Leu Gln Pro Asn Val Phe Val Trp His 
545                 550                 555                 560 


Lys Gly Asp Pro Cys Pro Gln Pro Arg Gln Leu Ser Thr Glu Gly Leu 
                565                 570                 575     


Pro Ala Cys Ala Pro Ser Val Val Arg Asp Tyr Phe Glu Gly Ser Gly 
            580                 585                 590         


Phe Gly Phe Gly Val Thr Ile Gly Thr Leu Cys Cys Phe Pro Leu Val 
        595                 600                 605             


Ser Leu Leu Ser Ala Trp Ile Val Ala Arg Leu Arg Met Arg Asn Phe 
    610                 615                 620                 


Lys Arg Leu Gln Gly Gln Asp Arg Gln Ser Ile Val Ser Glu Lys Leu 
625                 630                 635                 640 


Val Gly Gly Met Glu Ala Leu Glu Trp Gln Gly His Lys Glu Pro Cys 
                645                 650                 655     


Arg Pro Val Leu Val Tyr Leu Gln Pro Gly Gln Ile Arg Val Val Asp 
            660                 665                 670         


Gly Arg Leu Thr Val Leu Arg Thr Ile Gln Leu Gln Pro Pro Gln Lys 
        675                 680                 685             


Val Asn Phe Val Leu Ser Ser Asn Arg Gly Arg Arg Thr Leu Leu Leu 
    690                 695                 700                 


Lys Ile Pro Lys Glu Tyr Asp Leu Val Leu Leu Phe Asn Leu Glu Glu 
705                 710                 715                 720 


Glu Arg Gln Ala Leu Val Glu Asn Leu Arg Gly Ala Leu Lys Glu Ser 
                725                 730                 735     


Gly Leu Ser Ile Gln Glu Trp Glu Leu Arg Glu Gln Glu Leu Met Arg 
            740                 745                 750         


Ala Ala Val Thr Arg Glu Gln Arg Arg His Leu Leu Glu Thr Phe Phe 
        755                 760                 765             


Arg His Leu Phe Ser Gln Val Leu Asp Ile Asn Gln Ala Asp Ala Gly 
    770                 775                 780                 


Thr Leu Pro Leu Asp Ser Ser Gln Lys Val Arg Glu Ala Leu Thr Cys 
785                 790                 795                 800 


Glu Leu Ser Arg Ala Glu Phe Ala Glu Ser Leu Gly Leu Lys Pro Gln 
                805                 810                 815     


Asp Met Phe Val Glu Ser Met Phe Ser Leu Ala Asp Lys Asp Gly Asn 
            820                 825                 830         


Gly Tyr Leu Ser Phe Arg Glu Phe Leu Asp Ile Leu Val Val Phe Met 
        835                 840                 845             


Lys Gly Ser Pro Glu Glu Lys Ser Arg Leu Met Phe Arg Met Tyr Asp 
    850                 855                 860                 


Phe Asp Gly Asn Gly Leu Ile Ser Lys Asp Glu Phe Ile Arg Met Leu 
865                 870                 875                 880 


Arg Ser Phe Ile Glu Ile Ser Asn Asn Cys Leu Ser Lys Ala Gln Leu 
                885                 890                 895     


Ala Glu Val Val Glu Ser Met Phe Arg Glu Ser Gly Phe Gln Asp Lys 
            900                 905                 910         


Glu Glu Leu Thr Trp Glu Asp Phe His Phe Met Leu Arg Asp His Asn 
        915                 920                 925             


Ser Glu Leu Arg Phe Thr Gln Leu Cys Val Lys Gly Val Glu Val Pro 
    930                 935                 940                 


Glu Val Ile Lys Asp Leu Cys Arg Arg Ala Ser Tyr Ile Ser Gln Asp 
945                 950                 955                 960 


Met Ile Cys Pro Ser Pro Arg Val Ser Ala Arg Cys Ser Arg Ser Asp 
                965                 970                 975     


Ile Glu Thr Glu Leu Thr Pro Gln Arg Leu Gln Cys Pro Met Asp Thr 
            980                 985                 990         


Asp Pro Pro Gln Glu Ile Arg Arg  Arg Phe Gly Lys Lys  Val Thr Ser 
        995                 1000                 1005             


Phe Gln  Pro Leu Leu Phe Thr  Glu Ala His Arg Glu  Lys Phe Gln 
    1010                 1015                 1020             


Arg Ser  Cys Leu His Gln Thr  Val Gln Gln Phe Lys  Arg Phe Ile 
    1025                 1030                 1035             


Glu Asn  Tyr Arg Arg His Ile  Gly Cys Val Ala Val  Phe Tyr Ala 
    1040                 1045                 1050             


Ile Ala  Gly Gly Leu Phe Leu  Glu Arg Ala Tyr Tyr  Tyr Ala Phe 
    1055                 1060                 1065             


Ala Ala  His His Thr Gly Ile  Thr Asp Thr Thr Arg  Val Gly Ile 
    1070                 1075                 1080             


Ile Leu  Ser Arg Gly Thr Ala  Ala Ser Ile Ser Phe  Met Phe Ser 
    1085                 1090                 1095             


Tyr Ile  Leu Leu Thr Met Cys  Arg Asn Leu Ile Thr  Phe Leu Arg 
    1100                 1105                 1110             


Glu Thr  Phe Leu Asn Arg Tyr  Val Pro Phe Asp Ala  Ala Val Asp 
    1115                 1120                 1125             


Phe His  Arg Leu Ile Ala Ser  Thr Ala Ile Val Leu  Thr Val Leu 
    1130                 1135                 1140             


His Ser  Val Gly His Val Val  Asn Val Tyr Leu Phe  Ser Ile Ser 
    1145                 1150                 1155             


Pro Leu  Ser Val Leu Ser Cys  Leu Phe Pro Gly Leu  Phe His Asp 
    1160                 1165                 1170             


Asp Gly  Ser Glu Leu Pro Gln  Lys Tyr Tyr Trp Trp  Phe Phe Gln 
    1175                 1180                 1185             


Thr Val  Pro Gly Leu Thr Gly  Val Val Leu Leu Leu  Ile Leu Ala 
    1190                 1195                 1200             


Ile Met  Tyr Val Phe Ala Ser  His His Phe Arg Arg  Arg Ser Phe 
    1205                 1210                 1215             


Arg Gly  Phe Trp Leu Thr His  His Leu Tyr Ile Leu  Leu Tyr Val 
    1220                 1225                 1230             


Leu Leu  Ile Ile His Gly Ser  Phe Ala Leu Ile Gln  Leu Pro Arg 
    1235                 1240                 1245             


Phe His  Ile Phe Phe Leu Val  Pro Ala Ile Ile Tyr  Gly Gly Asp 
    1250                 1255                 1260             


Lys Leu  Val Ser Leu Ser Arg  Lys Lys Val Glu Ile  Ser Val Val 
    1265                 1270                 1275             


Lys Ala  Glu Leu Leu Pro Ser  Gly Val Thr His Leu  Arg Phe Gln 
    1280                 1285                 1290             


Arg Pro  Gln Gly Phe Glu Tyr  Lys Ser Gly Gln Trp  Val Arg Ile 
    1295                 1300                 1305             


Ala Cys  Leu Ala Leu Gly Thr  Thr Glu Tyr His Pro  Phe Thr Leu 
    1310                 1315                 1320             


Thr Ser  Ala Pro His Glu Asp  Thr Leu Ser Leu His  Ile Arg Ala 
    1325                 1330                 1335             


Ala Gly  Pro Trp Thr Thr Arg  Leu Arg Glu Ile Tyr  Ser Ala Pro 
    1340                 1345                 1350             


Thr Gly  Asp Arg Cys Ala Arg  Tyr Pro Lys Leu Tyr  Leu Asp Gly 
    1355                 1360                 1365             


Pro Phe  Gly Glu Gly His Gln  Glu Trp His Lys Phe  Glu Val Ser 
    1370                 1375                 1380             


Val Leu  Val Gly Gly Gly Ile  Gly Val Thr Pro Phe  Ala Ser Ile 
    1385                 1390                 1395             


Leu Lys  Asp Leu Val Phe Lys  Ser Ser Val Ser Cys  Gln Val Phe 
    1400                 1405                 1410             


Cys Lys  Lys Ile Tyr Phe Ile  Trp Val Thr Arg Thr  Gln Arg Gln 
    1415                 1420                 1425             


Phe Glu  Trp Leu Ala Asp Ile  Ile Arg Glu Val Glu  Glu Asn Asp 
    1430                 1435                 1440             


His Gln  Asp Leu Val Ser Val  His Ile Tyr Ile Thr  Gln Leu Ala 
    1445                 1450                 1455             


Glu Lys  Phe Asp Leu Arg Thr  Thr Met Leu Tyr Ile  Cys Glu Arg 
    1460                 1465                 1470             


His Phe  Gln Lys Val Leu Asn  Arg Ser Leu Phe Thr  Gly Leu Arg 
    1475                 1480                 1485             


Ser Ile  Thr His Phe Gly Arg  Pro Pro Phe Glu Pro  Phe Phe Asn 
    1490                 1495                 1500             


Ser Leu  Gln Glu Val His Pro  Gln Val Arg Lys Ile  Gly Val Phe 
    1505                 1510                 1515             


Ser Cys  Gly Pro Pro Gly Met  Thr Lys Asn Val Glu  Lys Ala Cys 
    1520                 1525                 1530             


Gln Leu  Ile Asn Arg Gln Asp  Arg Thr His Phe Ser  His His Tyr 
    1535                 1540                 1545             


Glu Asn  Phe 
    1550     


<210>  4472
<211>  444
<212>  PRT
<213>  Homo Sapiens

<400>  4472

Met Gly Phe Cys Leu Ala Leu Ala Trp Thr Leu Leu Val Gly Ala Trp 
1               5                   10                  15      


Thr Pro Leu Gly Ala Gln Asn Pro Ile Ser Trp Glu Val Gln Arg Phe 
            20                  25                  30          


Asp Gly Trp Tyr Asn Asn Leu Met Glu His Arg Trp Gly Ser Lys Gly 
        35                  40                  45              


Ser Arg Leu Gln Arg Leu Val Pro Ala Ser Tyr Ala Asp Gly Val Tyr 
    50                  55                  60                  


Gln Pro Leu Gly Glu Pro His Leu Pro Asn Pro Arg Asp Leu Ser Asn 
65                  70                  75                  80  


Thr Ile Ser Arg Gly Pro Ala Gly Leu Ala Ser Leu Arg Asn Arg Thr 
                85                  90                  95      


Val Leu Gly Val Phe Phe Gly Tyr His Val Leu Ser Asp Leu Val Ser 
            100                 105                 110         


Val Glu Thr Pro Gly Cys Pro Ala Glu Phe Leu Asn Ile Arg Ile Pro 
        115                 120                 125             


Pro Gly Asp Pro Met Phe Asp Pro Asp Gln Arg Gly Asp Val Val Leu 
    130                 135                 140                 


Pro Phe Gln Arg Ser Arg Trp Asp Pro Glu Thr Gly Arg Ser Pro Ser 
145                 150                 155                 160 


Asn Pro Arg Asp Pro Ala Asn Gln Val Thr Gly Trp Leu Asp Gly Ser 
                165                 170                 175     


Ala Ile Tyr Gly Ser Ser His Ser Trp Ser Asp Ala Leu Arg Ser Phe 
            180                 185                 190         


Ser Arg Gly Gln Leu Ala Ser Gly Pro Asp Pro Ala Phe Pro Arg Asp 
        195                 200                 205             


Ser Gln Asn Pro Leu Leu Met Trp Ala Ala Pro Asp Pro Ala Thr Gly 
    210                 215                 220                 


Gln Asn Gly Pro Arg Gly Leu Tyr Ala Phe Gly Ala Glu Arg Gly Asn 
225                 230                 235                 240 


Arg Glu Pro Phe Leu Gln Ala Leu Gly Leu Leu Trp Phe Arg Tyr His 
                245                 250                 255     


Asn Leu Trp Ala Gln Arg Leu Ala Arg Gln His Pro Asp Trp Glu Asp 
            260                 265                 270         


Glu Glu Leu Phe Gln His Ala Arg Lys Arg Val Ile Ala Thr Tyr Gln 
        275                 280                 285             


Asn Ile Ala Val Tyr Glu Trp Leu Pro Ser Phe Leu Gln Lys Thr Leu 
    290                 295                 300                 


Pro Glu Tyr Thr Gly Tyr Arg Pro Phe Leu Asp Pro Ser Ile Ser Ser 
305                 310                 315                 320 


Glu Phe Val Ala Ala Ser Glu Gln Phe Leu Ser Thr Met Val Pro Pro 
                325                 330                 335     


Gly Val Tyr Met Arg Asn Ala Ser Cys His Phe Gln Gly Val Ile Asn 
            340                 345                 350         


Arg Asn Ser Ser Val Ser Arg Ala Leu Arg Val Cys Asn Ser Tyr Trp 
        355                 360                 365             


Ser Arg Glu His Pro Ser Leu Gln Ser Ala Glu Asp Val Asp Ala Leu 
    370                 375                 380                 


Leu Leu Gly Met Ala Ser Gln Ile Ala Glu Arg Glu Asp His Val Leu 
385                 390                 395                 400 


Val Glu Asp Val Arg Gly Thr Gly Gly His Ser Cys Pro Val Gln Pro 
                405                 410                 415     


Gly Leu Ile Leu Ala Arg Ala Ala Pro Trp Gly Thr Pro Gly Glu Pro 
            420                 425                 430         


Pro Gly Pro Trp Thr Ser Val Gln His His Arg Pro 
        435                 440                 


<210>  4473
<211>  1197
<212>  PRT
<213>  Homo Sapiens

<400>  4473

Met Trp Met His Cys Cys Trp Ala Trp Pro Pro Arg Ser Gln Ser Glu 
1               5                   10                  15      


Arg Thr Met Cys Trp Leu Lys Met Cys Gly Val Ser Leu Arg Leu Ser 
            20                  25                  30          


Leu Gln Val Val Asn Ser Trp Pro Leu Gly Arg Gly Ser Ala Gly Leu 
        35                  40                  45              


Pro Glu Pro Asp Phe Trp Pro Gly Pro Leu Lys Phe Ser Arg Thr Asp 
    50                  55                  60                  


His Leu Ala Ser Cys Leu Gln Arg Gly Arg Asp Leu Gly Leu Pro Ser 
65                  70                  75                  80  


Tyr Thr Lys Ala Arg Ala Ala Leu Gly Leu Ser Pro Ile Thr Arg Trp 
                85                  90                  95      


Gln Asp Ile Asn Pro Ala Leu Ser Arg Ser Asn Asp Thr Val Leu Glu 
            100                 105                 110         


Ala Thr Ala Ala Leu Tyr Asn Gln Asp Leu Ser Trp Leu Glu Leu Leu 
        115                 120                 125             


Pro Gly Gly Leu Leu Glu Ser His Arg Asp Pro Gly Pro Leu Phe Ser 
    130                 135                 140                 


Thr Ile Val Leu Glu Gln Phe Val Arg Leu Arg Asp Gly Asp Arg Tyr 
145                 150                 155                 160 


Trp Phe Glu Asn Thr Arg Asn Gly Leu Phe Ser Lys Lys Glu Ile Glu 
                165                 170                 175     


Glu Ile Arg Asn Thr Thr Leu Gln Asp Val Leu Val Ala Val Ile Asn 
            180                 185                 190         


Ile Asp Pro Ser Ala Leu Gln Pro Asn Val Phe Val Trp His Lys Gly 
        195                 200                 205             


Asp Pro Cys Pro Gln Pro Arg Gln Leu Ser Thr Glu Gly Leu Pro Ala 
    210                 215                 220                 


Cys Ala Pro Ser Val Val Arg Asp Tyr Phe Glu Gly Ser Gly Phe Gly 
225                 230                 235                 240 


Phe Gly Val Thr Ile Gly Thr Leu Cys Cys Phe Pro Leu Val Ser Leu 
                245                 250                 255     


Leu Ser Ala Trp Ile Val Ala Arg Leu Arg Met Arg Asn Phe Lys Arg 
            260                 265                 270         


Leu Gln Gly Gln Asp Arg Gln Ser Ile Val Ser Glu Lys Leu Val Gly 
        275                 280                 285             


Gly Met Glu Ala Leu Glu Trp Gln Gly His Lys Glu Pro Cys Arg Pro 
    290                 295                 300                 


Val Leu Val Tyr Leu Gln Pro Gly Gln Ile Arg Val Val Asp Gly Arg 
305                 310                 315                 320 


Leu Thr Val Leu Arg Thr Ile Gln Leu Gln Pro Pro Gln Lys Val Asn 
                325                 330                 335     


Phe Val Leu Ser Ser Asn Arg Gly Arg Arg Thr Leu Leu Leu Lys Ile 
            340                 345                 350         


Pro Lys Glu Tyr Asp Leu Val Leu Leu Phe Asn Leu Glu Glu Glu Arg 
        355                 360                 365             


Gln Ala Leu Val Glu Asn Leu Arg Gly Ala Leu Lys Glu Ser Gly Leu 
    370                 375                 380                 


Ser Ile Gln Glu Trp Glu Leu Arg Glu Gln Glu Leu Met Arg Ala Ala 
385                 390                 395                 400 


Val Thr Arg Glu Gln Arg Arg His Leu Leu Glu Thr Phe Phe Arg His 
                405                 410                 415     


Leu Phe Ser Gln Val Leu Asp Ile Asn Gln Ala Asp Ala Gly Thr Leu 
            420                 425                 430         


Pro Leu Asp Ser Ser Gln Lys Val Arg Glu Ala Leu Thr Cys Glu Leu 
        435                 440                 445             


Ser Arg Ala Glu Phe Ala Glu Ser Leu Gly Leu Lys Pro Gln Asp Met 
    450                 455                 460                 


Phe Val Glu Ser Met Phe Ser Leu Ala Asp Lys Asp Gly Asn Gly Tyr 
465                 470                 475                 480 


Leu Ser Phe Arg Glu Phe Leu Asp Ile Leu Val Val Phe Met Lys Gly 
                485                 490                 495     


Ser Pro Glu Glu Lys Ser Arg Leu Met Phe Arg Met Tyr Asp Phe Asp 
            500                 505                 510         


Gly Asn Gly Leu Ile Ser Lys Asp Glu Phe Ile Arg Met Leu Arg Ser 
        515                 520                 525             


Phe Ile Glu Ile Ser Asn Asn Cys Leu Ser Lys Ala Gln Leu Ala Glu 
    530                 535                 540                 


Val Val Glu Ser Met Phe Arg Glu Ser Gly Phe Gln Asp Lys Glu Glu 
545                 550                 555                 560 


Leu Thr Trp Glu Asp Phe His Phe Met Leu Arg Asp His Asn Ser Glu 
                565                 570                 575     


Leu Arg Phe Thr Gln Leu Cys Val Lys Gly Val Glu Val Pro Glu Val 
            580                 585                 590         


Ile Lys Asp Leu Cys Arg Arg Ala Ser Tyr Ile Ser Gln Asp Met Ile 
        595                 600                 605             


Cys Pro Ser Pro Arg Val Ser Ala Arg Cys Ser Arg Ser Asp Ile Glu 
    610                 615                 620                 


Thr Glu Leu Thr Pro Gln Arg Leu Gln Cys Pro Met Asp Thr Asp Pro 
625                 630                 635                 640 


Pro Gln Glu Ile Arg Arg Arg Phe Gly Lys Lys Val Thr Ser Phe Gln 
                645                 650                 655     


Pro Leu Leu Phe Thr Glu Ala His Arg Glu Lys Phe Gln Arg Ser Cys 
            660                 665                 670         


Leu His Gln Thr Val Gln Gln Phe Lys Arg Phe Ile Glu Asn Tyr Arg 
        675                 680                 685             


Arg His Ile Gly Cys Val Ala Val Phe Tyr Ala Ile Ala Gly Gly Leu 
    690                 695                 700                 


Phe Leu Glu Arg Ala Tyr Tyr Tyr Ala Phe Ala Ala His His Thr Gly 
705                 710                 715                 720 


Ile Thr Asp Thr Thr Arg Val Gly Ile Ile Leu Ser Arg Gly Thr Ala 
                725                 730                 735     


Ala Ser Ile Ser Phe Met Phe Ser Tyr Ile Leu Leu Thr Met Cys Arg 
            740                 745                 750         


Asn Leu Ile Thr Phe Leu Arg Glu Thr Phe Leu Asn Arg Tyr Val Pro 
        755                 760                 765             


Phe Asp Ala Ala Val Asp Phe His Arg Leu Ile Ala Ser Thr Ala Ile 
    770                 775                 780                 


Val Leu Thr Val Leu His Ser Val Gly His Val Val Asn Val Tyr Leu 
785                 790                 795                 800 


Phe Ser Ile Ser Pro Leu Ser Val Leu Ser Cys Leu Phe Pro Gly Leu 
                805                 810                 815     


Phe His Asp Asp Gly Ser Glu Leu Pro Gln Lys Tyr Tyr Trp Trp Phe 
            820                 825                 830         


Phe Gln Thr Val Pro Gly Leu Thr Gly Val Val Leu Leu Leu Ile Leu 
        835                 840                 845             


Ala Ile Met Tyr Val Phe Ala Ser His His Phe Arg Arg Arg Ser Phe 
    850                 855                 860                 


Arg Gly Phe Trp Leu Thr His His Leu Tyr Ile Leu Leu Tyr Val Leu 
865                 870                 875                 880 


Leu Ile Ile His Gly Ser Phe Ala Leu Ile Gln Leu Pro Arg Phe His 
                885                 890                 895     


Ile Phe Phe Leu Val Pro Ala Ile Ile Tyr Gly Gly Asp Lys Leu Val 
            900                 905                 910         


Ser Leu Ser Arg Lys Lys Val Glu Ile Ser Val Val Lys Ala Glu Leu 
        915                 920                 925             


Leu Pro Ser Gly Val Thr His Leu Arg Phe Gln Arg Pro Gln Gly Phe 
    930                 935                 940                 


Glu Tyr Lys Ser Gly Gln Trp Val Arg Ile Ala Cys Leu Ala Leu Gly 
945                 950                 955                 960 


Thr Thr Glu Tyr His Pro Phe Thr Leu Thr Ser Ala Pro His Glu Asp 
                965                 970                 975     


Thr Leu Ser Leu His Ile Arg Ala Ala Gly Pro Trp Thr Thr Arg Leu 
            980                 985                 990         


Arg Glu Ile Tyr Ser Ala Pro Thr  Gly Asp Arg Cys Ala  Arg Tyr Pro 
        995                 1000                 1005             


Lys Leu  Tyr Leu Asp Gly Pro  Phe Gly Glu Gly His  Gln Glu Trp 
    1010                 1015                 1020             


His Lys  Phe Glu Val Ser Val  Leu Val Gly Gly Gly  Ile Gly Val 
    1025                 1030                 1035             


Thr Pro  Phe Ala Ser Ile Leu  Lys Asp Leu Val Phe  Lys Ser Ser 
    1040                 1045                 1050             


Val Ser  Cys Gln Val Phe Cys  Lys Lys Ile Tyr Phe  Ile Trp Val 
    1055                 1060                 1065             


Thr Arg  Thr Gln Arg Gln Phe  Glu Trp Leu Ala Asp  Ile Ile Arg 
    1070                 1075                 1080             


Glu Val  Glu Glu Asn Asp His  Gln Asp Leu Val Ser  Val His Ile 
    1085                 1090                 1095             


Tyr Ile  Thr Gln Leu Ala Glu  Lys Phe Asp Leu Arg  Thr Thr Met 
    1100                 1105                 1110             


Leu Tyr  Ile Cys Glu Arg His  Phe Gln Lys Val Leu  Asn Arg Ser 
    1115                 1120                 1125             


Leu Phe  Thr Gly Leu Arg Ser  Ile Thr His Phe Gly  Arg Pro Pro 
    1130                 1135                 1140             


Phe Glu  Pro Phe Phe Asn Ser  Leu Gln Glu Val His  Pro Gln Val 
    1145                 1150                 1155             


Arg Lys  Ile Gly Val Phe Ser  Cys Gly Pro Pro Gly  Met Thr Lys 
    1160                 1165                 1170             


Asn Val  Glu Lys Ala Cys Gln  Leu Ile Asn Arg Gln  Asp Arg Thr 
    1175                 1180                 1185             


His Phe  Ser His His Tyr Glu  Asn Phe 
    1190                 1195         


<210>  4474
<211>  122
<212>  PRT
<213>  Homo Sapiens

<400>  4474

Met Ala Arg Ser Leu Gly Val Leu Val Ala Leu Pro Phe Pro Leu Pro 
1               5                   10                  15      


Val Gly Phe Asn Ala Glu Glu Ala His Asn Ile Val Lys Glu Cys Val 
            20                  25                  30          


Asp Gly Val Leu Gly Gly Glu Asp Tyr Asn His Asn Asn Ile Asn Gln 
        35                  40                  45              


Trp Thr Ala Ser Ile Val Glu Gln Ser Leu Thr His Leu Val Lys Leu 
    50                  55                  60                  


Gly Lys Ala Tyr Lys Tyr Ile Val Thr Cys Ala Val Val Gln Lys Ser 
65                  70                  75                  80  


Ala Tyr Gly Phe His Thr Ala Ser Ser Cys Phe Trp Asp Thr Thr Ser 
                85                  90                  95      


Asp Gly Thr Cys Thr Val Arg Trp Glu Asn Arg Thr Met Asn Cys Ile 
            100                 105                 110         


Val Asn Val Phe Ala Ile Ala Ile Val Leu 
        115                 120         


<210>  4475
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  4475

Met Glu Glu Tyr His Arg His Cys Asp Glu Val Gly Phe Asn Ala Glu 
1               5                   10                  15      


Glu Ala His Asn Ile Val Lys Glu Cys Val Asp Gly Val Leu Gly Gly 
            20                  25                  30          


Glu Asp Tyr Asn His Asn Asn Ile Asn Gln Trp Thr Ala Ser Ile Val 
        35                  40                  45              


Glu Gln Ser Leu Thr His Leu Val Lys Leu Gly Lys Ala Tyr Lys Tyr 
    50                  55                  60                  


Ile Val Thr Cys Ala Val Val Gln Lys Ser Ala Tyr Gly Phe His Thr 
65                  70                  75                  80  


Ala Ser Ser Cys Phe Trp Asp Thr Thr Ser Asp Gly Thr Cys Thr Val 
                85                  90                  95      


Arg Trp Glu Asn Arg Thr Met Asn Cys Gly Val Leu Leu Cys Arg Pro 
            100                 105                 110         


Gly Trp Ser Ala Val Met Gln Phe Arg Leu Thr Ala Thr Ser Ala Ser 
        115                 120                 125             


Gln Val Gln Val Ile Leu Leu Pro Gln Pro Pro Glu Tyr Leu Glu Leu 
    130                 135                 140                 


Gln Ala His Ala Ile Thr Pro Gly 
145                 150         


<210>  4476
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  4476

Met Glu Glu Tyr His Arg His Cys Asp Glu Val Gly Phe Asn Ala Glu 
1               5                   10                  15      


Glu Ala His Asn Ile Val Lys Glu Cys Val Asp Gly Val Leu Gly Gly 
            20                  25                  30          


Glu Asp Tyr Asn His Asn Asn Ile Asn Gln Trp Thr Ala Ser Ile Val 
        35                  40                  45              


Glu Gln Ser Leu Thr His Leu Val Lys Leu Gly Lys Ala Tyr Lys Tyr 
    50                  55                  60                  


Ile Val Thr Cys Ala Val Val Gln Lys Ser Ala Tyr Gly Phe His Thr 
65                  70                  75                  80  


Ala Ser Ser Cys Phe Trp Asp Thr Thr Ser Asp Gly Thr Cys Thr Val 
                85                  90                  95      


Arg Trp Glu Asn Arg Thr Met Asn Cys Ile Val Asn Val Phe Ala Ile 
            100                 105                 110         


Ala Ile Val Leu 
        115     


<210>  4477
<211>  346
<212>  PRT
<213>  Homo Sapiens

<400>  4477

Met Ala Ala Ala Glu Pro Ala Ser Ser Gly Gln Gln Ala Pro Ala Gly 
1               5                   10                  15      


Gln Gly Gln Gly Gln Arg Pro Pro Pro Gln Pro Pro Gln Ala Gln Ala 
            20                  25                  30          


Pro Gln Pro Pro Pro Pro Pro Gln Leu Gly Gly Ala Gly Gly Gly Ser 
        35                  40                  45              


Ser Arg His Glu Lys Ser Leu Gly Leu Leu Thr Thr Lys Phe Val Ser 
    50                  55                  60                  


Leu Leu Gln Glu Ala Lys Asp Gly Val Leu Asp Leu Lys Ala Ala Ala 
65                  70                  75                  80  


Asp Thr Leu Ala Val Arg Gln Lys Arg Arg Ile Tyr Asp Ile Thr Asn 
                85                  90                  95      


Val Leu Glu Gly Ile Asp Leu Ile Glu Lys Lys Ser Lys Asn Ser Ile 
            100                 105                 110         


Gln Trp Lys Gly Val Gly Ala Gly Cys Asn Thr Lys Glu Val Ile Asp 
        115                 120                 125             


Arg Leu Arg Tyr Leu Lys Ala Glu Ile Glu Asp Leu Glu Leu Lys Glu 
    130                 135                 140                 


Arg Glu Leu Asp Gln Gln Lys Leu Trp Leu Gln Gln Ser Ile Lys Asn 
145                 150                 155                 160 


Val Met Asp Asp Ser Ile Asn Asn Arg Phe Ser Tyr Val Thr His Glu 
                165                 170                 175     


Asp Ile Cys Asn Cys Phe Asn Gly Asp Thr Leu Leu Ala Ile Gln Ala 
            180                 185                 190         


Pro Ser Gly Thr Gln Leu Glu Val Pro Ile Pro Glu Met Gly Gln Asn 
        195                 200                 205             


Gly Gln Lys Lys Tyr Gln Ile Asn Leu Lys Ser His Ser Gly Pro Ile 
    210                 215                 220                 


His Val Leu Leu Ile Asn Lys Glu Ser Ser Ser Ser Lys Pro Val Val 
225                 230                 235                 240 


Phe Pro Val Pro Pro Pro Asp Asp Leu Thr Gln Pro Ser Ser Gln Ser 
                245                 250                 255     


Leu Thr Pro Val Thr Pro Gln Lys Ser Ser Met Ala Thr Gln Asn Leu 
            260                 265                 270         


Pro Glu Gln His Val Ser Glu Arg Ser Gln Ala Leu Gln Gln Thr Ser 
        275                 280                 285             


Ala Thr Asp Ile Ser Ser Ala Gly Ser Ile Ser Gly Asp Ile Ile Asp 
    290                 295                 300                 


Glu Leu Met Ser Ser Asp Val Phe Pro Leu Leu Arg Leu Ser Pro Thr 
305                 310                 315                 320 


Pro Ala Asp Asp Tyr Asn Phe Asn Leu Asp Asp Asn Glu Gly Val Cys 
                325                 330                 335     


Asp Leu Phe Asp Val Gln Ile Leu Asn Tyr 
            340                 345     


<210>  4478
<211>  345
<212>  PRT
<213>  Homo Sapiens

<400>  4478

Met Ala Ala Ala Glu Pro Ala Ser Ser Gly Gln Gln Ala Pro Ala Gly 
1               5                   10                  15      


Gln Gly Gln Gly Gln Arg Pro Pro Pro Gln Pro Pro Gln Ala Gln Ala 
            20                  25                  30          


Pro Gln Pro Pro Pro Pro Pro Gln Leu Gly Gly Ala Gly Gly Gly Ser 
        35                  40                  45              


Ser Arg His Glu Lys Ser Leu Gly Leu Leu Thr Thr Lys Phe Val Ser 
    50                  55                  60                  


Leu Leu Gln Glu Ala Lys Asp Gly Val Leu Asp Leu Lys Ala Ala Ala 
65                  70                  75                  80  


Asp Thr Leu Ala Val Arg Gln Lys Arg Arg Ile Tyr Asp Ile Thr Asn 
                85                  90                  95      


Val Leu Glu Gly Ile Asp Leu Ile Glu Lys Lys Ser Lys Asn Ser Ile 
            100                 105                 110         


Gln Trp Lys Gly Val Gly Ala Gly Cys Asn Thr Lys Glu Val Ile Asp 
        115                 120                 125             


Arg Leu Arg Tyr Leu Lys Ala Glu Ile Glu Asp Leu Glu Leu Lys Glu 
    130                 135                 140                 


Arg Glu Leu Asp Gln Gln Lys Leu Trp Leu Gln Gln Ser Ile Lys Asn 
145                 150                 155                 160 


Val Met Asp Asp Ser Ile Asn Asn Arg Phe Ser Tyr Val Thr His Glu 
                165                 170                 175     


Asp Ile Cys Asn Cys Phe Asn Gly Asp Thr Leu Leu Ala Ile Gln Ala 
            180                 185                 190         


Pro Ser Gly Thr Gln Leu Glu Val Pro Ile Pro Glu Met Gly Gln Asn 
        195                 200                 205             


Gly Gln Lys Lys Tyr Gln Ile Asn Leu Lys Ser His Ser Gly Pro Ile 
    210                 215                 220                 


His Val Leu Leu Ile Asn Lys Glu Ser Ser Ser Ser Lys Pro Val Val 
225                 230                 235                 240 


Phe Pro Val Pro Pro Pro Asp Asp Leu Thr Gln Pro Ser Ser Gln Ser 
                245                 250                 255     


Leu Thr Pro Val Thr Pro Gln Lys Ser Ser Met Ala Thr Gln Asn Leu 
            260                 265                 270         


Pro Glu Gln His Val Ser Glu Arg Ser Gln Ala Leu Gln Gln Thr Ser 
        275                 280                 285             


Ala Thr Asp Ile Ser Ser Gly Ser Ile Ser Gly Asp Ile Ile Asp Glu 
    290                 295                 300                 


Leu Met Ser Ser Asp Val Phe Pro Leu Leu Arg Leu Ser Pro Thr Pro 
305                 310                 315                 320 


Ala Asp Asp Tyr Asn Phe Asn Leu Asp Asp Asn Glu Gly Val Cys Asp 
                325                 330                 335     


Leu Phe Asp Val Gln Ile Leu Asn Tyr 
            340                 345 


<210>  4479
<211>  185
<212>  PRT
<213>  Homo Sapiens

<400>  4479

Met Asp Asp Ser Ile Asn Asn Arg Phe Ser Tyr Val Thr His Glu Asp 
1               5                   10                  15      


Ile Cys Asn Cys Phe Asn Gly Asp Thr Leu Leu Ala Ile Gln Ala Pro 
            20                  25                  30          


Ser Gly Thr Gln Leu Glu Val Pro Ile Pro Glu Met Gly Gln Asn Gly 
        35                  40                  45              


Gln Lys Lys Tyr Gln Ile Asn Leu Lys Ser His Ser Gly Pro Ile His 
    50                  55                  60                  


Val Leu Leu Ile Asn Lys Glu Ser Ser Ser Ser Lys Pro Val Val Phe 
65                  70                  75                  80  


Pro Val Pro Pro Pro Asp Asp Leu Thr Gln Pro Ser Ser Gln Ser Leu 
                85                  90                  95      


Thr Pro Val Thr Pro Gln Lys Ser Ser Met Ala Thr Gln Asn Leu Pro 
            100                 105                 110         


Glu Gln His Val Ser Glu Arg Ser Gln Ala Leu Gln Gln Thr Ser Ala 
        115                 120                 125             


Thr Asp Ile Ser Ser Ala Gly Ser Ile Ser Gly Asp Ile Ile Asp Glu 
    130                 135                 140                 


Leu Met Ser Ser Asp Val Phe Pro Leu Leu Arg Leu Ser Pro Thr Pro 
145                 150                 155                 160 


Ala Asp Asp Tyr Asn Phe Asn Leu Asp Asp Asn Glu Gly Val Cys Asp 
                165                 170                 175     


Leu Phe Asp Val Gln Ile Leu Asn Tyr 
            180                 185 


<210>  4480
<211>  173
<212>  PRT
<213>  Homo Sapiens

<400>  4480

Met Lys Thr Ser Val Ile Ala Leu Met Val Ser Asp Thr Leu Leu Ala 
1               5                   10                  15      


Ile Gln Ala Pro Ser Gly Thr Gln Leu Glu Val Pro Ile Pro Glu Met 
            20                  25                  30          


Gly Gln Asn Gly Gln Lys Lys Tyr Gln Ile Asn Leu Lys Ser His Ser 
        35                  40                  45              


Gly Pro Ile His Val Leu Leu Ile Asn Lys Glu Ser Ser Ser Ser Lys 
    50                  55                  60                  


Pro Val Val Phe Pro Val Pro Pro Pro Asp Asp Leu Thr Gln Pro Ser 
65                  70                  75                  80  


Ser Gln Ser Leu Thr Pro Val Thr Pro Gln Lys Ser Ser Met Ala Thr 
                85                  90                  95      


Gln Asn Leu Pro Glu Gln His Val Ser Glu Arg Ser Gln Ala Leu Gln 
            100                 105                 110         


Gln Thr Ser Ala Thr Asp Ile Ser Ser Ala Gly Ser Ile Ser Gly Asp 
        115                 120                 125             


Ile Ile Asp Glu Leu Met Ser Ser Asp Val Phe Pro Leu Leu Arg Leu 
    130                 135                 140                 


Ser Pro Thr Pro Ala Asp Asp Tyr Asn Phe Asn Leu Asp Asp Asn Glu 
145                 150                 155                 160 


Gly Val Cys Asp Leu Phe Asp Val Gln Ile Leu Asn Tyr 
                165                 170             


<210>  4481
<211>  182
<212>  PRT
<213>  Homo Sapiens

<400>  4481

Ser Tyr Asp Ser Thr Phe Ser Tyr Val Thr His Glu Asp Ile Cys Asn 
1               5                   10                  15      


Cys Phe Asn Gly Asp Thr Leu Leu Ala Ile Gln Ala Pro Ser Gly Thr 
            20                  25                  30          


Gln Leu Glu Val Pro Ile Pro Glu Met Gly Gln Asn Gly Gln Lys Lys 
        35                  40                  45              


Tyr Gln Ile Asn Leu Lys Ser His Ser Gly Pro Ile His Val Leu Leu 
    50                  55                  60                  


Ile Asn Lys Glu Ser Ser Ser Ser Lys Pro Val Val Phe Pro Val Pro 
65                  70                  75                  80  


Pro Pro Asp Asp Leu Thr Gln Pro Ser Ser Gln Ser Leu Thr Pro Val 
                85                  90                  95      


Thr Pro Gln Lys Ser Ser Met Ala Thr Gln Asn Leu Pro Glu Gln His 
            100                 105                 110         


Val Ser Glu Arg Ser Gln Ala Leu Gln Gln Thr Ser Ala Thr Asp Ile 
        115                 120                 125             


Ser Ser Ala Gly Ser Ile Ser Gly Asp Ile Ile Asp Glu Leu Met Ser 
    130                 135                 140                 


Ser Asp Val Phe Pro Leu Leu Arg Leu Ser Pro Thr Pro Ala Asp Asp 
145                 150                 155                 160 


Tyr Asn Phe Asn Leu Asp Asp Asn Glu Gly Val Cys Asp Leu Phe Asp 
                165                 170                 175     


Val Gln Ile Leu Asn Tyr 
            180         


<210>  4482
<211>  249
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4482

Xaa Leu Leu Gln Glu Ala Lys Asp Gly Val Leu Asp Leu Lys Ala Ala 
1               5                   10                  15      


Ala Asp Thr Leu Ala Val Arg Gln Lys Arg Arg Ile Tyr Asp Ile Thr 
            20                  25                  30          


Asn Val Leu Glu Gly Ile Asp Leu Ile Glu Lys Lys Ser Lys Asn Ser 
        35                  40                  45              


Ile Gln Trp Lys Gly Val Gly Ala Gly Cys Asn Thr Lys Glu Val Ile 
    50                  55                  60                  


Asp Arg Leu Arg Tyr Leu Lys Ala Glu Ile Glu Asp Leu Glu Leu Lys 
65                  70                  75                  80  


Glu Arg Glu Leu Asp Gln Gln Lys Leu Trp Leu Gln Gln Ser Ile Lys 
                85                  90                  95      


Asn Val Met Asp Asp Ser Ile Asn Asn Arg Phe Ser Tyr Val Thr His 
            100                 105                 110         


Glu Asp Ile Cys Asn Cys Phe Asn Gly Asp Thr Leu Leu Ala Ile Gln 
        115                 120                 125             


Ala Pro Ser Gly Thr Gln Leu Glu Val Pro Ile Pro Glu Met Gly Gln 
    130                 135                 140                 


Asn Gly Gln Lys Lys Tyr Gln Ile Asn Leu Lys Ser His Ser Gly Pro 
145                 150                 155                 160 


Ile His Val Leu Leu Ile Asn Lys Glu Ser Ser Ser Ser Lys Pro Val 
                165                 170                 175     


Val Phe Pro Val Pro Pro Pro Asp Asp Leu Thr Gln Pro Ser Ser Gln 
            180                 185                 190         


Ser Leu Thr Pro Val Thr Pro Gln Lys Ser Ser Met Ala Thr Gln Asn 
        195                 200                 205             


Leu Pro Glu Gln His Val Ser Glu Arg Ser Gln Ala Leu Gln Gln Thr 
    210                 215                 220                 


Ser Ala Thr Asp Ile Ser Ser Ala Gly Ser Ile Ser Gly Asp Ile Ile 
225                 230                 235                 240 


Asp Glu Leu Met Ser Ser Asp Gly Lys 
                245                 


<210>  4483
<211>  130
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4483

Xaa Asn Lys Glu Ser Ser Ser Ser Lys Pro Val Val Phe Pro Val Pro 
1               5                   10                  15      


Pro Pro Asp Asp Leu Thr Gln Pro Ser Ser Gln Ser Leu Thr Pro Val 
            20                  25                  30          


Thr Pro Gln Lys Ser Ser Met Ala Thr Gln Asn Leu Pro Glu Gln His 
        35                  40                  45              


Val Ser Glu Arg Ser Gln Ala Leu Gln Gln Thr Ser Ala Thr Asp Ile 
    50                  55                  60                  


Ser Ser Ala Gly Ser Ile Ser Gly Asp Ile Ile Asp Glu Leu Met Ser 
65                  70                  75                  80  


Ser Asp Gly Gly Lys Leu Lys Asp Thr Thr Gly His Gln Lys Gln Val 
                85                  90                  95      


Gly Gln Gly Leu Ile Thr Cys Leu Ile Phe Leu Leu Pro Leu Asn Cys 
            100                 105                 110         


Leu Tyr Phe Cys Met Ser Phe Tyr Pro Asn Arg Arg Ser Leu Pro Leu 
        115                 120                 125             


Val Lys 
    130 


<210>  4484
<211>  78
<212>  PRT
<213>  Homo Sapiens

<400>  4484

Met Ala Ile Thr Gln Phe Arg Leu Phe Lys Phe Cys Thr Cys Leu Ala 
1               5                   10                  15      


Thr Val Phe Ser Phe Leu Lys Arg Leu Ile Cys Arg Ser Gly Arg Gly 
            20                  25                  30          


Arg Lys Leu Ser Gly Asp Gln Ile Thr Leu Pro Thr Thr Val Asp Tyr 
        35                  40                  45              


Ser Ser Val Pro Lys Gln Thr Asp Val Glu Glu Trp Thr Ser Trp Asp 
    50                  55                  60                  


Glu Asp Ala Pro Thr Ser Val Lys Ile Glu Gly Gly Asn Gly 
65                  70                  75              


<210>  4485
<211>  197
<212>  PRT
<213>  Homo Sapiens

<400>  4485

Met Ala Ile Thr Gln Phe Arg Leu Phe Lys Phe Cys Thr Cys Leu Ala 
1               5                   10                  15      


Thr Val Phe Ser Phe Leu Lys Arg Leu Ile Cys Arg Ser Gly Arg Gly 
            20                  25                  30          


Arg Lys Leu Ser Gly Asp Gln Ile Thr Leu Pro Thr Thr Val Asp Tyr 
        35                  40                  45              


Ser Ser Val Pro Lys Gln Thr Asp Val Glu Glu Trp Thr Ser Trp Asp 
    50                  55                  60                  


Glu Asp Ala Pro Thr Ser Val Lys Ile Glu Gly Gly Asn Gly Asn Val 
65                  70                  75                  80  


Ala Thr Gln Gln Asn Ser Leu Glu Gln Leu Glu Pro Asp Tyr Phe Lys 
                85                  90                  95      


Asp Met Thr Pro Thr Ile Arg Lys Thr Gln Lys Ile Val Ile Lys Lys 
            100                 105                 110         


Arg Glu Pro Leu Asn Phe Gly Ile Pro Asp Gly Ser Thr Gly Phe Ser 
        115                 120                 125             


Ser Arg Leu Ala Ala Thr Gln Asp Leu Pro Phe Ile His Gln Ser Ser 
    130                 135                 140                 


Glu Leu Gly Asp Leu Asp Thr Trp Gln Glu Asn Thr Asn Ala Trp Glu 
145                 150                 155                 160 


Glu Glu Glu Asp Ala Ala Trp Gln Ala Glu Glu Val Leu Arg Gln Gln 
                165                 170                 175     


Lys Leu Ala Asp Arg Glu Lys Arg Ala Ala Glu Gln Gln Arg Lys Lys 
            180                 185                 190         


Met Glu Lys Glu Ala 
        195         


<210>  4486
<211>  213
<212>  PRT
<213>  Homo Sapiens

<400>  4486

Met Ala Ile Thr Gln Phe Arg Leu Phe Lys Phe Cys Thr Cys Leu Ala 
1               5                   10                  15      


Thr Val Phe Ser Phe Leu Lys Arg Leu Ile Cys Arg Ser Gly Arg Gly 
            20                  25                  30          


Arg Lys Leu Ser Gly Asp Gln Ile Thr Leu Pro Thr Thr Val Asp Tyr 
        35                  40                  45              


Ser Ser Val Pro Lys Gln Thr Asp Val Glu Glu Trp Thr Ser Trp Asp 
    50                  55                  60                  


Glu Asp Ala Pro Thr Ser Val Lys Ile Glu Gly Gly Asn Gly Asn Val 
65                  70                  75                  80  


Ala Thr Gln Gln Asn Ser Leu Glu Gln Leu Glu Pro Asp Tyr Phe Lys 
                85                  90                  95      


Asp Met Thr Pro Thr Ile Arg Lys Thr Gln Lys Ile Val Ile Lys Lys 
            100                 105                 110         


Arg Glu Pro Leu Asn Phe Gly Ile Pro Asp Gly Ser Thr Gly Phe Ser 
        115                 120                 125             


Ser Arg Leu Ala Ala Thr Gln Asp Leu Pro Phe Ile His Gln Ser Ser 
    130                 135                 140                 


Glu Leu Gly Asp Leu Asp Thr Trp Gln Glu Asn Thr Asn Ala Trp Glu 
145                 150                 155                 160 


Glu Glu Glu Asp Ala Ala Trp Gln Ala Glu Glu Val Leu Arg Gln Gln 
                165                 170                 175     


Lys Leu Ala Asp Arg Glu Lys Arg Ala Ala Glu Gln Gln Arg Lys Lys 
            180                 185                 190         


Met Glu Lys Glu Ala Gln Arg Leu Met Lys Lys Glu Gln Asn Lys Ile 
        195                 200                 205             


Gly Val Lys Leu Ser 
    210             


<210>  4487
<211>  213
<212>  PRT
<213>  Homo Sapiens

<400>  4487

Met Ala Ile Thr Gln Phe Arg Leu Phe Lys Phe Cys Thr Cys Leu Ala 
1               5                   10                  15      


Thr Val Phe Ser Phe Leu Lys Arg Leu Ile Cys Arg Ser Gly Arg Gly 
            20                  25                  30          


Arg Lys Leu Ser Gly Asp Gln Ile Thr Leu Pro Thr Thr Val Asp Tyr 
        35                  40                  45              


Ser Ser Val Pro Lys Gln Thr Asp Val Glu Glu Trp Thr Ser Trp Asp 
    50                  55                  60                  


Glu Asp Ala Pro Thr Ser Val Lys Ile Glu Gly Gly Asn Gly Asn Val 
65                  70                  75                  80  


Ala Thr Gln Gln Asn Ser Leu Glu Gln Leu Glu Pro Asp Tyr Phe Lys 
                85                  90                  95      


Asp Met Thr Pro Thr Ile Arg Lys Thr Gln Lys Ile Val Ile Lys Lys 
            100                 105                 110         


Arg Glu Pro Leu Asn Phe Gly Ile Pro Asp Gly Ser Thr Gly Phe Ser 
        115                 120                 125             


Ser Arg Leu Ala Ala Thr Gln Asp Leu Pro Phe Ile His Gln Ser Ser 
    130                 135                 140                 


Glu Leu Gly Asp Leu Asp Thr Trp Gln Glu Asn Thr Asn Ala Trp Glu 
145                 150                 155                 160 


Glu Glu Glu Asp Ala Ala Trp Gln Ala Glu Glu Val Leu Arg Gln Gln 
                165                 170                 175     


Lys Leu Ala Asp Arg Glu Lys Arg Ala Ala Glu Gln Gln Arg Lys Lys 
            180                 185                 190         


Met Glu Lys Glu Ala Gln Arg Leu Met Lys Lys Glu Gln Asn Lys Ile 
        195                 200                 205             


Gly Val Lys Leu Ser 
    210             


<210>  4488
<211>  213
<212>  PRT
<213>  Homo Sapiens

<400>  4488

Met Ala Ile Thr Gln Phe Arg Leu Phe Lys Phe Cys Thr Cys Leu Ala 
1               5                   10                  15      


Thr Val Phe Ser Phe Leu Lys Arg Leu Ile Cys Arg Ser Gly Arg Gly 
            20                  25                  30          


Arg Lys Leu Ser Gly Asp Gln Ile Thr Leu Pro Thr Thr Val Asp Tyr 
        35                  40                  45              


Ser Ser Val Pro Lys Gln Thr Asp Val Glu Glu Trp Thr Ser Trp Asp 
    50                  55                  60                  


Glu Asp Ala Pro Thr Ser Val Lys Ile Glu Gly Gly Asn Gly Asn Val 
65                  70                  75                  80  


Ala Thr Gln Gln Asn Ser Leu Glu Gln Leu Glu Pro Asp Tyr Phe Lys 
                85                  90                  95      


Asp Met Thr Pro Thr Ile Arg Lys Thr Gln Lys Ile Val Ile Lys Lys 
            100                 105                 110         


Arg Glu Pro Leu Asn Phe Gly Ile Pro Asp Gly Ser Thr Gly Phe Ser 
        115                 120                 125             


Ser Arg Leu Ala Ala Thr Gln Asp Leu Pro Phe Ile His Gln Ser Ser 
    130                 135                 140                 


Glu Leu Gly Asp Leu Asp Thr Trp Gln Glu Asn Thr Asn Ala Trp Glu 
145                 150                 155                 160 


Glu Glu Glu Asp Ala Ala Trp Gln Ala Glu Glu Val Leu Arg Gln Gln 
                165                 170                 175     


Lys Leu Ala Asp Arg Glu Lys Arg Ala Ala Glu Gln Gln Arg Lys Lys 
            180                 185                 190         


Met Glu Lys Glu Ala Gln Arg Leu Met Lys Lys Glu Gln Asn Lys Ile 
        195                 200                 205             


Gly Val Lys Leu Ser 
    210             


<210>  4489
<211>  258
<212>  PRT
<213>  Homo Sapiens

<400>  4489

Met Ala Ile Thr Gln Phe Arg Leu Phe Lys Phe Cys Thr Cys Leu Ala 
1               5                   10                  15      


Thr Val Phe Ser Phe Leu Lys Arg Leu Ile Cys Arg Ser Gly Arg Gly 
            20                  25                  30          


Arg Lys Leu Ser Gly Asp Gln Ile Thr Leu Pro Thr Thr Val Asp Tyr 
        35                  40                  45              


Ser Ser Val Pro Lys Gln Thr Asp Val Glu Glu Trp Thr Ser Trp Asp 
    50                  55                  60                  


Glu Asp Ala Pro Thr Ser Val Lys Ile Glu Gly Gly Asn Gly Asn Val 
65                  70                  75                  80  


Ala Thr Gln Gln Asn Ser Leu Glu Gln Leu Glu Pro Asp Tyr Phe Lys 
                85                  90                  95      


Asp Met Thr Pro Thr Ile Arg Lys Thr Gln Lys Ile Val Ile Lys Lys 
            100                 105                 110         


Arg Glu Pro Leu Asn Phe Gly Ile Pro Asp Gly Ser Thr Gly Phe Ser 
        115                 120                 125             


Ser Arg Leu Ala Ala Thr Gln Asp Leu Pro Phe Ile His Gln Ser Ser 
    130                 135                 140                 


Glu Leu Gly Asp Leu Asp Thr Trp Gln Glu Asn Thr Asn Ala Trp Glu 
145                 150                 155                 160 


Glu Glu Glu Asp Ala Ala Trp Gln Ala Glu Glu Val Leu Arg Ser Arg 
                165                 170                 175     


Thr Asn Val Cys Leu Leu Cys Ser Leu Leu Phe His His Pro Thr Pro 
            180                 185                 190         


Thr Ser Thr Pro Tyr Ile Asn Gln Ser Val Lys Ile Glu Arg Val Ser 
        195                 200                 205             


Leu Gly Gln Trp Ser Tyr Gly Lys Ser Lys Glu Gln Gln Lys Leu Ala 
    210                 215                 220                 


Asp Arg Glu Lys Arg Ala Ala Glu Gln Gln Arg Lys Lys Met Glu Lys 
225                 230                 235                 240 


Glu Ala Gln Arg Leu Met Lys Lys Glu Gln Asn Lys Ile Gly Val Lys 
                245                 250                 255     


Leu Ser 
        


<210>  4490
<211>  258
<212>  PRT
<213>  Homo Sapiens

<400>  4490

Met Ala Ile Thr Gln Phe Arg Leu Phe Lys Phe Cys Thr Cys Leu Ala 
1               5                   10                  15      


Thr Val Phe Ser Phe Leu Lys Arg Leu Ile Cys Arg Ser Gly Arg Gly 
            20                  25                  30          


Arg Lys Leu Ser Gly Asp Gln Ile Thr Leu Pro Thr Thr Val Asp Tyr 
        35                  40                  45              


Ser Ser Val Pro Lys Gln Thr Asp Val Glu Glu Trp Thr Ser Trp Asp 
    50                  55                  60                  


Glu Asp Ala Pro Thr Ser Val Lys Ile Glu Gly Gly Asn Gly Asn Val 
65                  70                  75                  80  


Ala Thr Gln Gln Asn Ser Leu Glu Gln Leu Glu Pro Asp Tyr Phe Lys 
                85                  90                  95      


Asp Met Thr Pro Thr Ile Arg Lys Thr Gln Lys Ile Val Ile Lys Lys 
            100                 105                 110         


Arg Glu Pro Leu Asn Phe Gly Ile Pro Asp Gly Ser Thr Gly Phe Ser 
        115                 120                 125             


Ser Arg Leu Ala Ala Thr Gln Asp Leu Pro Phe Ile His Gln Ser Ser 
    130                 135                 140                 


Glu Leu Gly Asp Leu Asp Thr Trp Gln Glu Asn Thr Asn Ala Trp Glu 
145                 150                 155                 160 


Glu Glu Glu Asp Ala Ala Trp Gln Ala Glu Glu Val Leu Arg Ser Arg 
                165                 170                 175     


Thr Asn Val Cys Leu Leu Cys Ser Leu Leu Phe His His Pro Thr Pro 
            180                 185                 190         


Thr Ser Thr Pro Tyr Ile Asn Gln Ser Val Lys Ile Glu Arg Val Ser 
        195                 200                 205             


Leu Gly Gln Trp Ser Tyr Gly Lys Ser Lys Glu Gln Gln Lys Leu Ala 
    210                 215                 220                 


Asp Arg Glu Lys Arg Ala Ala Glu Gln Gln Arg Lys Lys Met Glu Lys 
225                 230                 235                 240 


Glu Ala Gln Arg Leu Met Lys Lys Glu Gln Asn Lys Ile Gly Val Lys 
                245                 250                 255     


Leu Ser 
        


<210>  4491
<211>  153
<212>  PRT
<213>  Homo Sapiens

<400>  4491

Met Ala Ile Thr Gln Phe Arg Leu Phe Lys Phe Cys Thr Cys Leu Ala 
1               5                   10                  15      


Thr Val Phe Ser Phe Leu Lys Arg Leu Ile Cys Arg Ser Gly Arg Gly 
            20                  25                  30          


Arg Lys Leu Ser Gly Asp Gln Ile Thr Leu Pro Thr Thr Val Asp Tyr 
        35                  40                  45              


Ser Ser Val Pro Lys Gln Thr Asp Val Glu Glu Trp Thr Ser Trp Asp 
    50                  55                  60                  


Glu Asp Ala Pro Thr Ser Val Lys Ile Glu Gly Gly Asn Gly Asn Val 
65                  70                  75                  80  


Ala Thr Gln Gln Asn Ser Leu Glu Gln Leu Glu Pro Asp Tyr Phe Lys 
                85                  90                  95      


Asp Met Thr Pro Thr Ile Arg Lys Thr Gln Lys Ile Val Ile Lys Lys 
            100                 105                 110         


Arg Glu Pro Leu Asn Phe Gly Ile Pro Asp Gly Ser Thr Gly Phe Ser 
        115                 120                 125             


Ser Arg Leu Ala Ala Thr Gln Asp Leu Pro Phe Ile His Gln Ser Thr 
    130                 135                 140                 


Ser His Trp Val Gly Ala Thr Ile Ile 
145                 150             


<210>  4492
<211>  41
<212>  PRT
<213>  Homo Sapiens

<400>  4492

Met Thr Pro Thr Ile Arg Lys Thr Gln Lys Ile Val Ile Lys Lys Arg 
1               5                   10                  15      


Glu Pro Leu Asn Phe Gly Ile Pro Asp Gly Ser Thr Gly Phe Ser Ser 
            20                  25                  30          


Arg Leu Ala Ala Thr Gln Asp Leu Pro 
        35                  40      


<210>  4493
<211>  229
<212>  PRT
<213>  Homo Sapiens

<400>  4493

Met Thr Pro Gln Leu Leu Leu Ala Leu Val Leu Trp Ala Ser Cys Pro 
1               5                   10                  15      


Pro Cys Ser Gly Arg Lys Gly Pro Pro Ala Ala Leu Thr Leu Pro Arg 
            20                  25                  30          


Val Gln Cys Arg Ala Ser Arg Tyr Pro Ile Ala Val Asp Cys Ser Trp 
        35                  40                  45              


Thr Leu Pro Pro Ala Pro Asn Ser Thr Ser Pro Val Ser Phe Ile Ala 
    50                  55                  60                  


Thr Tyr Arg Leu Gly Met Ala Ala Arg Gly His Ser Trp Pro Cys Leu 
65                  70                  75                  80  


Gln Gln Thr Pro Thr Ser Thr Ser Cys Thr Ile Thr Asp Val Gln Leu 
                85                  90                  95      


Phe Ser Met Ala Pro Tyr Val Leu Asn Val Thr Ala Val His Pro Trp 
            100                 105                 110         


Gly Ser Ser Ser Ser Phe Val Pro Phe Ile Thr Glu His Ile Ile Lys 
        115                 120                 125             


Pro Asp Pro Pro Glu Gly Val Arg Leu Ser Pro Leu Ala Glu Arg Gln 
    130                 135                 140                 


Leu Gln Val Gln Trp Glu Pro Pro Gly Ser Trp Pro Phe Pro Glu Ile 
145                 150                 155                 160 


Phe Ser Leu Lys Tyr Trp Ile Arg Tyr Lys Arg Gln Gly Ala Ala Arg 
                165                 170                 175     


Phe His Arg Val Gly Pro Ile Glu Ala Thr Ser Phe Ile Leu Arg Ala 
            180                 185                 190         


Val Arg Pro Arg Ala Arg Tyr Tyr Val Gln Val Ala Ala Gln Asp Leu 
        195                 200                 205             


Thr Asp Tyr Gly Glu Leu Ser Asp Trp Ser Leu Pro Ala Thr Ala Thr 
    210                 215                 220                 


Met Ser Leu Gly Lys 
225                 


<210>  4494
<211>  83
<212>  PRT
<213>  Homo Sapiens

<400>  4494

Met Ala Lys Ser Leu Leu Lys Thr Ala Ser Leu Ser Gly Arg Thr Lys 
1               5                   10                  15      


Leu Leu His Gln Thr Gly Leu Ser Leu Tyr Ser Thr Ser His Gly Phe 
            20                  25                  30          


Tyr Glu Glu Glu Val Lys Lys Thr Leu Gln Gln Phe Pro Gly Gly Ser 
        35                  40                  45              


Ile Asp Leu Gln Lys Glu Asp Asn Gly Ile Gly Ile Leu Thr Leu Asn 
    50                  55                  60                  


Asn Pro Ser Arg Met Asn Ala Phe Ser Glu Phe Arg Glu Ile Ser Leu 
65                  70                  75                  80  


Tyr Gln Cys 
            


<210>  4495
<211>  125
<212>  PRT
<213>  Homo Sapiens

<400>  4495

Met Ala Lys Ser Leu Leu Lys Thr Ala Ser Leu Ser Gly Arg Thr Lys 
1               5                   10                  15      


Leu Leu His Gln Thr Gly Leu Ser Leu Tyr Ser Thr Ser His Gly Phe 
            20                  25                  30          


Tyr Glu Glu Glu Val Lys Lys Thr Leu Gln Gln Phe Pro Gly Gly Ser 
        35                  40                  45              


Ile Asp Leu Gln Lys Glu Asp Asn Gly Ile Gly Ile Leu Thr Leu Asn 
    50                  55                  60                  


Asn Pro Ser Arg Met Asn Ala Phe Ser Gly Val Met Met Leu Gln Leu 
65                  70                  75                  80  


Leu Glu Lys Val Ile Glu Leu Glu Asn Trp Thr Glu Gly Lys Gly Leu 
                85                  90                  95      


Ile Val Arg Gly Ala Lys Asn Thr Phe Ser Ser Gly Ser Asp Leu Asn 
            100                 105                 110         


Ala Val Lys Ser Leu Gly Thr Pro Glu Ala Asn Phe Leu 
        115                 120                 125 


<210>  4496
<211>  135
<212>  PRT
<213>  Homo Sapiens

<400>  4496

Met Ala Lys Ser Leu Leu Lys Thr Ala Ser Leu Ser Gly Arg Thr Lys 
1               5                   10                  15      


Leu Leu His Gln Thr Gly Leu Ser Leu Tyr Ser Thr Ser His Gly Phe 
            20                  25                  30          


Tyr Glu Glu Glu Val Lys Lys Thr Leu Gln Gln Phe Pro Gly Gly Ser 
        35                  40                  45              


Ile Asp Leu Gln Lys Glu Asp Asn Gly Ile Gly Ile Leu Thr Leu Asn 
    50                  55                  60                  


Asn Pro Ser Arg Met Asn Ala Phe Ser Gly Val Met Met Leu Gln Leu 
65                  70                  75                  80  


Leu Glu Lys Val Ile Glu Leu Glu Asn Trp Thr Glu Gly Lys Gly Leu 
                85                  90                  95      


Ile Val Arg Gly Ala Lys Asn Thr Phe Ser Ser Gly Ser Asp Leu Asn 
            100                 105                 110         


Ala Val Lys Ser Leu Gly Thr Pro Glu Asp Gly Met Ala Val Cys Met 
        115                 120                 125             


Phe Met Gln Asn Thr Leu Thr 
    130                 135 


<210>  4497
<211>  139
<212>  PRT
<213>  Homo Sapiens

<400>  4497

Met Ala Lys Ser Leu Leu Lys Thr Ala Ser Leu Ser Gly Arg Thr Lys 
1               5                   10                  15      


Leu Leu His Gln Thr Gly Leu Ser Leu Tyr Ser Thr Ser His Gly Phe 
            20                  25                  30          


Tyr Glu Glu Glu Val Lys Lys Thr Leu Gln Gln Phe Pro Gly Gly Ser 
        35                  40                  45              


Ile Asp Leu Gln Lys Glu Asp Asn Gly Ile Gly Ile Leu Thr Leu Asn 
    50                  55                  60                  


Asn Pro Ser Arg Met Asn Ala Phe Ser Gly Val Met Met Leu Gln Leu 
65                  70                  75                  80  


Leu Glu Lys Val Ile Glu Leu Glu Asn Trp Thr Glu Gly Lys Gly Leu 
                85                  90                  95      


Ile Val Arg Gly Ala Lys Asn Thr Phe Ser Ser Gly Ser Asp Leu Asn 
            100                 105                 110         


Ala Val Lys Ser Leu Gly Thr Pro Glu Asp Gly Met Ala Val Cys Met 
        115                 120                 125             


Phe Met Gln Asn Thr Leu Thr Arg Phe Met Arg 
    130                 135                 


<210>  4498
<211>  151
<212>  PRT
<213>  Homo Sapiens

<400>  4498

Met Ala Lys Ser Leu Leu Lys Thr Ala Ser Leu Ser Gly Arg Thr Lys 
1               5                   10                  15      


Leu Leu His Gln Thr Gly Leu Ser Leu Tyr Ser Thr Ser His Gly Phe 
            20                  25                  30          


Tyr Glu Glu Glu Val Lys Lys Thr Leu Gln Gln Phe Pro Gly Gly Ser 
        35                  40                  45              


Ile Asp Leu Gln Lys Glu Asp Asn Gly Ile Gly Ile Leu Thr Leu Asn 
    50                  55                  60                  


Asn Pro Ser Arg Met Asn Ala Phe Ser Gly Val Met Met Leu Gln Leu 
65                  70                  75                  80  


Leu Glu Lys Val Ile Glu Leu Glu Asn Trp Thr Glu Gly Lys Gly Leu 
                85                  90                  95      


Ile Val Arg Gly Ala Lys Asn Thr Phe Ser Ser Gly Ser Asp Leu Asn 
            100                 105                 110         


Ala Val Lys Ser Leu Gly Thr Pro Glu Asp Gly Met Ala Val Cys Met 
        115                 120                 125             


Phe Met Gln Asn Thr Leu Thr Arg Phe Met Arg Leu Pro Leu Ile Ser 
    130                 135                 140                 


Val Ala Leu Val Gln Gly Trp 
145                 150     


<210>  4499
<211>  301
<212>  PRT
<213>  Homo Sapiens

<400>  4499

Met Ala Lys Ser Leu Leu Lys Thr Ala Ser Leu Ser Gly Arg Thr Lys 
1               5                   10                  15      


Leu Leu His Gln Thr Gly Leu Ser Leu Tyr Ser Thr Ser His Gly Phe 
            20                  25                  30          


Tyr Glu Glu Glu Val Lys Lys Thr Leu Gln Gln Phe Pro Gly Gly Ser 
        35                  40                  45              


Ile Asp Leu Gln Lys Glu Asp Asn Gly Ile Gly Ile Leu Thr Leu Asn 
    50                  55                  60                  


Asn Pro Ser Arg Met Asn Ala Phe Ser Gly Val Met Met Leu Gln Leu 
65                  70                  75                  80  


Leu Glu Lys Val Ile Glu Leu Glu Asn Trp Thr Glu Gly Lys Gly Leu 
                85                  90                  95      


Ile Val Arg Gly Ala Lys Asn Thr Phe Ser Ser Gly Ser Asp Leu Asn 
            100                 105                 110         


Ala Val Lys Ser Leu Gly Thr Pro Glu Asp Gly Met Ala Val Cys Met 
        115                 120                 125             


Phe Met Gln Asn Thr Leu Thr Arg Phe Met Arg Leu Pro Leu Ile Ser 
    130                 135                 140                 


Val Ala Leu Val Gln Gly Trp Ala Leu Gly Gly Gly Ala Glu Phe Thr 
145                 150                 155                 160 


Thr Ala Cys Asp Phe Arg Leu Met Thr Pro Glu Ser Lys Ile Arg Phe 
                165                 170                 175     


Val His Lys Glu Met Gly Ile Ile Pro Ser Trp Gly Gly Thr Thr Arg 
            180                 185                 190         


Leu Val Glu Ile Ile Gly Ser Arg Gln Ala Leu Lys Val Leu Ser Gly 
        195                 200                 205             


Ala Leu Lys Leu Asp Ser Lys Asn Ala Leu Asn Ile Gly Met Val Glu 
    210                 215                 220                 


Glu Val Leu Gln Ser Ser Asp Glu Thr Lys Ser Leu Glu Glu Ala Gln 
225                 230                 235                 240 


Glu Trp Leu Lys Gln Phe Ile Gln Gly Pro Pro Glu Val Ile Arg Ala 
                245                 250                 255     


Leu Lys Lys Ser Val Cys Ser Gly Arg Glu Leu Tyr Leu Glu Glu Ala 
            260                 265                 270         


Leu Gln Asn Glu Arg Asp Leu Leu Gly Thr Val Trp Gly Gly Pro Ala 
        275                 280                 285             


Asn Leu Glu Ala Ile Ala Lys Lys Gly Lys Phe Asn Lys 
    290                 295                 300     


<210>  4500
<211>  301
<212>  PRT
<213>  Homo Sapiens

<400>  4500

Met Ala Lys Ser Leu Leu Lys Thr Ala Ser Leu Ser Gly Arg Thr Lys 
1               5                   10                  15      


Leu Leu His Gln Thr Gly Leu Ser Leu Tyr Ser Thr Ser His Gly Phe 
            20                  25                  30          


Tyr Glu Glu Glu Val Lys Lys Thr Leu Gln Gln Phe Pro Gly Gly Ser 
        35                  40                  45              


Ile Asp Leu Gln Lys Glu Asp Asn Gly Ile Gly Ile Leu Thr Leu Asn 
    50                  55                  60                  


Asn Pro Ser Arg Met Asn Ala Phe Ser Gly Val Met Met Leu Gln Leu 
65                  70                  75                  80  


Leu Glu Lys Val Ile Glu Leu Glu Asn Trp Thr Glu Gly Lys Gly Leu 
                85                  90                  95      


Ile Val Arg Gly Ala Lys Asn Thr Phe Ser Ser Gly Ser Asp Leu Asn 
            100                 105                 110         


Ala Val Lys Ser Leu Gly Thr Pro Glu Asp Gly Met Ala Val Cys Met 
        115                 120                 125             


Phe Met Gln Asn Thr Leu Thr Arg Phe Met Arg Leu Pro Leu Ile Ser 
    130                 135                 140                 


Val Ala Leu Val Gln Gly Trp Ala Leu Gly Gly Gly Ala Glu Phe Thr 
145                 150                 155                 160 


Thr Ala Cys Asp Phe Arg Leu Met Thr Pro Glu Ser Lys Ile Arg Phe 
                165                 170                 175     


Val His Lys Glu Met Gly Ile Ile Pro Ser Trp Gly Gly Thr Thr Arg 
            180                 185                 190         


Leu Val Glu Ile Ile Gly Ser Arg Gln Ala Leu Lys Val Leu Ser Gly 
        195                 200                 205             


Ala Leu Lys Leu Asp Ser Lys Asn Ala Leu Asn Ile Gly Met Val Glu 
    210                 215                 220                 


Glu Val Leu Gln Ser Ser Asp Glu Thr Lys Ser Leu Glu Glu Ala Gln 
225                 230                 235                 240 


Glu Trp Leu Lys Gln Phe Ile Gln Gly Pro Pro Glu Val Ile Arg Ala 
                245                 250                 255     


Leu Lys Lys Ser Val Cys Ser Gly Arg Glu Leu Tyr Leu Glu Glu Ala 
            260                 265                 270         


Leu Gln Asn Glu Arg Asp Leu Leu Gly Thr Val Trp Gly Gly Pro Ala 
        275                 280                 285             


Asn Leu Glu Ala Ile Ala Lys Lys Gly Lys Phe Asn Lys 
    290                 295                 300     


<210>  4501
<211>  301
<212>  PRT
<213>  Homo Sapiens

<400>  4501

Met Ala Lys Ser Leu Leu Lys Thr Ala Ser Leu Ser Gly Arg Thr Lys 
1               5                   10                  15      


Leu Leu His Gln Thr Gly Leu Ser Leu Tyr Ser Thr Ser His Gly Phe 
            20                  25                  30          


Tyr Glu Glu Glu Val Lys Lys Thr Leu Gln Gln Phe Pro Gly Gly Ser 
        35                  40                  45              


Ile Asp Leu Gln Lys Glu Asp Asn Gly Ile Gly Ile Leu Thr Leu Asn 
    50                  55                  60                  


Asn Pro Ser Arg Met Asn Ala Phe Ser Gly Val Met Met Leu Gln Leu 
65                  70                  75                  80  


Leu Glu Lys Val Ile Glu Leu Glu Asn Trp Thr Glu Gly Lys Gly Leu 
                85                  90                  95      


Ile Val Arg Gly Ala Lys Asn Thr Phe Ser Ser Gly Ser Asp Leu Asn 
            100                 105                 110         


Ala Val Lys Ser Leu Gly Thr Pro Glu Asp Gly Met Ala Val Cys Met 
        115                 120                 125             


Phe Met Gln Asn Thr Leu Thr Arg Phe Met Arg Leu Pro Leu Ile Ser 
    130                 135                 140                 


Val Ala Leu Val Gln Gly Trp Ala Leu Gly Gly Gly Ala Glu Phe Thr 
145                 150                 155                 160 


Thr Ala Cys Asp Phe Arg Leu Met Thr Pro Glu Ser Lys Ile Arg Phe 
                165                 170                 175     


Val His Lys Glu Met Gly Ile Ile Pro Ser Trp Gly Gly Thr Thr Arg 
            180                 185                 190         


Leu Val Glu Ile Ile Gly Ser Arg Gln Ala Leu Lys Val Leu Ser Gly 
        195                 200                 205             


Ala Leu Lys Leu Asp Ser Lys Asn Ala Leu Asn Ile Gly Met Val Glu 
    210                 215                 220                 


Glu Val Leu Gln Ser Ser Asp Glu Thr Lys Ser Leu Glu Glu Ala Gln 
225                 230                 235                 240 


Glu Trp Leu Lys Gln Phe Ile Gln Gly Pro Pro Glu Val Ile Arg Ala 
                245                 250                 255     


Leu Lys Lys Ser Val Cys Ser Gly Arg Glu Leu Tyr Leu Glu Glu Ala 
            260                 265                 270         


Leu Gln Asn Glu Arg Asp Leu Leu Gly Thr Val Trp Gly Gly Pro Ala 
        275                 280                 285             


Asn Leu Glu Ala Ile Ala Lys Lys Gly Lys Phe Asn Lys 
    290                 295                 300     


<210>  4502
<211>  179
<212>  PRT
<213>  Homo Sapiens

<400>  4502

Met Ala Lys Ser Leu Leu Lys Thr Ala Ser Leu Ser Gly Arg Thr Lys 
1               5                   10                  15      


Leu Leu His Gln Thr Gly Leu Ser Leu Tyr Ser Thr Ser His Gly Phe 
            20                  25                  30          


Tyr Glu Glu Glu Val Lys Lys Thr Leu Gln Gln Phe Pro Gly Gly Ser 
        35                  40                  45              


Ile Asp Leu Gln Lys Glu Asp Asn Gly Ile Gly Ile Leu Thr Leu Asn 
    50                  55                  60                  


Asn Pro Ser Arg Met Asn Ala Phe Ser Gly Val Met Met Leu Gln Leu 
65                  70                  75                  80  


Leu Glu Lys Val Ile Glu Leu Glu Asn Trp Thr Glu Gly Lys Gly Leu 
                85                  90                  95      


Ile Val Arg Gly Ala Lys Asn Thr Phe Ser Ser Gly Ser Asp Leu Asn 
            100                 105                 110         


Ala Val Lys Ser Leu Gly Thr Pro Glu Glu Ser Cys Arg Trp Asn Thr 
        115                 120                 125             


Glu Phe Leu Tyr Thr Leu His Pro Val Ser Pro Phe Ile Asn Ile Leu 
    130                 135                 140                 


Tyr Ser Tyr Gly Trp Asn Gly Arg Met His Val His Ala Lys His Leu 
145                 150                 155                 160 


Asn Lys Ile Tyr Glu Thr Ser Phe Asn Lys Cys Cys Ala Gly Ser Arg 
                165                 170                 175     


Leu Gly Ile 
            


<210>  4503
<211>  125
<212>  PRT
<213>  Homo Sapiens

<400>  4503

Met Ala Lys Ser Leu Leu Lys Thr Ala Ser Leu Ser Gly Arg Thr Lys 
1               5                   10                  15      


Leu Leu His Gln Thr Gly Leu Ser Leu Tyr Ser Thr Ser His Gly Phe 
            20                  25                  30          


Tyr Glu Glu Glu Val Lys Lys Thr Leu Gln Gln Phe Pro Gly Gly Ser 
        35                  40                  45              


Ile Asp Leu Gln Lys Glu Asp Asn Gly Ile Gly Ile Leu Thr Leu Asn 
    50                  55                  60                  


Asn Pro Ser Arg Met Asn Ala Phe Ser Gly Val Met Met Leu Gln Leu 
65                  70                  75                  80  


Leu Glu Lys Val Ile Glu Leu Glu Asn Trp Thr Glu Gly Lys Gly Leu 
                85                  90                  95      


Ile Val Arg Gly Ala Lys Asn Thr Phe Ser Ser Gly Ser Asp Leu Asn 
            100                 105                 110         


Ala Val Lys Ser Leu Gly Thr Pro Glu Gly Asp Phe Leu 
        115                 120                 125 


<210>  4504
<211>  145
<212>  PRT
<213>  Homo Sapiens

<400>  4504

Met Ala Lys Ser Leu Leu Lys Thr Ala Ser Leu Ser Gly Arg Thr Lys 
1               5                   10                  15      


Leu Leu His Gln Thr Gly Leu Ser Leu Tyr Ser Thr Ser His Gly Phe 
            20                  25                  30          


Tyr Glu Glu Glu Val Lys Lys Thr Leu Gln Gln Phe Pro Gly Gly Ser 
        35                  40                  45              


Ile Asp Leu Gln Lys Glu Asp Asn Gly Ile Gly Ile Leu Thr Leu Asn 
    50                  55                  60                  


Asn Pro Ser Arg Met Asn Ala Phe Ser Gly Val Met Met Leu Gln Leu 
65                  70                  75                  80  


Leu Glu Lys Val Ile Glu Leu Glu Asn Trp Thr Glu Gly Lys Gly Leu 
                85                  90                  95      


Ile Val Arg Gly Ala Lys Asn Thr Phe Ser Ser Gly Ser Asp Leu Asn 
            100                 105                 110         


Ala Val Lys Ser Leu Gly Thr Pro Glu Thr Ser Phe Asn Lys Cys Cys 
        115                 120                 125             


Ala Gly Ser Arg Leu Gly Ile Gly Trp Arg Ser Arg Ile Tyr Tyr Ser 
    130                 135                 140                 


Met 
145 


<210>  4505
<211>  145
<212>  PRT
<213>  Homo Sapiens

<400>  4505

Met Ala Lys Ser Leu Leu Lys Thr Ala Ser Leu Ser Gly Arg Thr Lys 
1               5                   10                  15      


Leu Leu His Gln Thr Gly Leu Ser Leu Tyr Ser Thr Ser His Gly Phe 
            20                  25                  30          


Tyr Glu Glu Glu Val Lys Lys Thr Leu Gln Gln Phe Pro Gly Gly Ser 
        35                  40                  45              


Ile Asp Leu Gln Lys Glu Asp Asn Gly Ile Gly Ile Leu Thr Leu Asn 
    50                  55                  60                  


Asn Pro Ser Arg Met Asn Ala Phe Ser Gly Val Met Met Leu Gln Leu 
65                  70                  75                  80  


Leu Glu Lys Val Ile Glu Leu Glu Asn Trp Thr Glu Gly Lys Gly Leu 
                85                  90                  95      


Ile Val Arg Gly Ala Lys Asn Thr Phe Ser Ser Gly Ser Asp Leu Asn 
            100                 105                 110         


Ala Val Lys Ser Leu Gly Thr Pro Glu Thr Ser Phe Asn Lys Cys Cys 
        115                 120                 125             


Ala Gly Ser Arg Leu Gly Ile Gly Trp Arg Ser Arg Ile Tyr Tyr Ser 
    130                 135                 140                 


Met 
145 


<210>  4506
<211>  307
<212>  PRT
<213>  Homo Sapiens

<400>  4506

Met Ala Leu Lys Gln Glu Met Ala Lys Ser Leu Leu Lys Thr Ala Ser 
1               5                   10                  15      


Leu Ser Gly Arg Thr Lys Leu Leu His Gln Thr Gly Leu Ser Leu Tyr 
            20                  25                  30          


Ser Thr Ser His Gly Phe Tyr Glu Glu Glu Val Lys Lys Thr Leu Gln 
        35                  40                  45              


Gln Phe Pro Gly Gly Ser Ile Asp Leu Gln Lys Glu Asp Asn Gly Ile 
    50                  55                  60                  


Gly Ile Leu Thr Leu Asn Asn Pro Ser Arg Met Asn Ala Phe Ser Gly 
65                  70                  75                  80  


Val Met Met Leu Gln Leu Leu Glu Lys Val Ile Glu Leu Glu Asn Trp 
                85                  90                  95      


Thr Glu Gly Lys Gly Leu Ile Val Arg Gly Ala Lys Asn Thr Phe Ser 
            100                 105                 110         


Ser Gly Ser Asp Leu Asn Ala Val Lys Ser Leu Gly Thr Pro Glu Asp 
        115                 120                 125             


Gly Met Ala Val Cys Met Phe Met Gln Asn Thr Leu Thr Arg Phe Met 
    130                 135                 140                 


Arg Leu Pro Leu Ile Ser Val Ala Leu Val Gln Gly Trp Ala Leu Gly 
145                 150                 155                 160 


Gly Gly Ala Glu Phe Thr Thr Ala Cys Asp Phe Arg Leu Met Thr Pro 
                165                 170                 175     


Glu Ser Lys Ile Arg Phe Val His Lys Glu Met Gly Ile Ile Pro Ser 
            180                 185                 190         


Trp Gly Gly Thr Thr Arg Leu Val Glu Ile Ile Gly Ser Arg Gln Ala 
        195                 200                 205             


Leu Lys Val Leu Ser Gly Ala Leu Lys Leu Asp Ser Lys Asn Ala Leu 
    210                 215                 220                 


Asn Ile Gly Met Val Glu Glu Val Leu Gln Ser Ser Asp Glu Thr Lys 
225                 230                 235                 240 


Ser Leu Glu Glu Ala Gln Glu Trp Leu Lys Gln Phe Ile Gln Gly Pro 
                245                 250                 255     


Pro Glu Val Ile Arg Ala Leu Lys Lys Ser Val Cys Ser Gly Arg Glu 
            260                 265                 270         


Leu Tyr Leu Glu Glu Ala Leu Gln Asn Glu Arg Asp Leu Leu Gly Thr 
        275                 280                 285             


Val Trp Gly Gly Pro Ala Asn Leu Glu Ala Ile Ala Lys Lys Gly Lys 
    290                 295                 300                 


Phe Asn Lys 
305         


<210>  4507
<211>  226
<212>  PRT
<213>  Homo Sapiens

<400>  4507

Met Met Leu Gln Leu Leu Glu Lys Val Ile Glu Leu Glu Asn Trp Thr 
1               5                   10                  15      


Glu Gly Lys Gly Leu Ile Val Arg Gly Ala Lys Asn Thr Phe Ser Ser 
            20                  25                  30          


Gly Ser Asp Leu Asn Ala Val Lys Ser Leu Gly Thr Pro Glu Asp Gly 
        35                  40                  45              


Met Ala Val Cys Met Phe Met Gln Asn Thr Leu Thr Arg Phe Met Arg 
    50                  55                  60                  


Leu Pro Leu Ile Ser Val Ala Leu Val Gln Gly Trp Ala Leu Gly Gly 
65                  70                  75                  80  


Gly Ala Glu Phe Thr Thr Ala Cys Asp Phe Arg Leu Met Thr Pro Glu 
                85                  90                  95      


Ser Lys Ile Arg Phe Val His Lys Glu Met Gly Ile Ile Pro Ser Trp 
            100                 105                 110         


Gly Gly Thr Thr Arg Leu Val Glu Ile Ile Gly Ser Arg Gln Ala Leu 
        115                 120                 125             


Lys Val Leu Ser Gly Ala Leu Lys Leu Asp Ser Lys Asn Ala Leu Asn 
    130                 135                 140                 


Ile Gly Met Val Glu Glu Val Leu Gln Ser Ser Asp Glu Thr Lys Ser 
145                 150                 155                 160 


Leu Glu Glu Ala Gln Glu Trp Leu Lys Gln Phe Ile Gln Gly Pro Pro 
                165                 170                 175     


Glu Val Ile Arg Ala Leu Lys Lys Ser Val Cys Ser Gly Arg Glu Leu 
            180                 185                 190         


Tyr Leu Glu Glu Ala Leu Gln Asn Glu Arg Asp Leu Leu Gly Thr Val 
        195                 200                 205             


Trp Gly Gly Pro Ala Asn Leu Glu Ala Ile Ala Lys Lys Gly Lys Phe 
    210                 215                 220                 


Asn Lys 
225     


<210>  4508
<211>  70
<212>  PRT
<213>  Homo Sapiens

<400>  4508

Met Met Leu Gln Leu Leu Glu Lys Val Ile Glu Leu Glu Asn Trp Thr 
1               5                   10                  15      


Glu Gly Lys Gly Leu Ile Val Arg Gly Ala Lys Asn Thr Phe Ser Ser 
            20                  25                  30          


Gly Ser Asp Leu Asn Ala Val Lys Ser Leu Gly Thr Pro Glu Thr Ser 
        35                  40                  45              


Phe Asn Lys Cys Cys Ala Gly Ser Arg Leu Gly Ile Gly Trp Arg Ser 
    50                  55                  60                  


Arg Ile Tyr Tyr Ser Met 
65                  70  


<210>  4509
<211>  34
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4509

Xaa Phe Met Arg Leu Pro Leu Ile Ser Val Ala Leu Val Gln Gly Trp 
1               5                   10                  15      


Ala Leu Gly Gly Gly Ala Glu Phe Thr Thr Ala Cys Asp Phe Ser Phe 
            20                  25                  30          


Arg His 
        


<210>  4510
<211>  76
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4510

Xaa Met Leu Gln Leu Leu Glu Lys Val Ile Glu Leu Glu Asn Trp Thr 
1               5                   10                  15      


Glu Gly Lys Gly Leu Ile Val Arg Gly Ala Lys Asn Thr Phe Ser Ser 
            20                  25                  30          


Gly Ser Asp Leu Asn Ala Val Lys Ser Leu Gly Thr Pro Glu Asp Gly 
        35                  40                  45              


Met Ala Val Cys Met Phe Met Gln Asn Thr Leu Thr Arg Phe Met Ser 
    50                  55                  60                  


Arg Met Cys Gly Glu Val Val Cys Ile Gln Arg Arg 
65                  70                  75      


<210>  4511
<211>  100
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4511

Xaa Thr Pro Glu Val Lys Lys Gln Arg Gly Lys Ile Leu Leu Gly Leu 
1               5                   10                  15      


Ser Arg Leu Pro Leu Ile Ser Val Ala Leu Val Gln Gly Trp Ala Leu 
            20                  25                  30          


Gly Gly Gly Ala Glu Phe Thr Thr Ala Cys Asp Phe Arg Leu Met Thr 
        35                  40                  45              


Pro Glu Ser Lys Ile Arg Phe Val His Lys Glu Met Gly Ile Ile Pro 
    50                  55                  60                  


Ser Trp Gly Gly Thr Thr Arg Leu Val Glu Ile Ile Gly Ser Arg Gln 
65                  70                  75                  80  


Ala Leu Lys Val Leu Ser Gly Ala Leu Lys Leu Asp Ser Lys Asn Ala 
                85                  90                  95      


Leu Asn Ile Gly 
            100 


<210>  4512
<211>  255
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4512

Xaa Thr Ser His Gly Phe Tyr Glu Glu Glu Val Lys Lys Thr Leu Gln 
1               5                   10                  15      


Gln Phe Pro Gly Gly Ser Ile Asp Leu Gln Lys Glu Asp Asn Gly Ile 
            20                  25                  30          


Gly Ile Leu Thr Leu Asn Asn Pro Ser Arg Met Asn Ala Phe Ser Gly 
        35                  40                  45              


Val Met Met Leu Gln Leu Leu Glu Lys Val Ile Glu Leu Glu Asn Trp 
    50                  55                  60                  


Thr Glu Gly Lys Gly Leu Ile Val Arg Gly Ala Lys Asn Thr Phe Ser 
65                  70                  75                  80  


Ser Gly Ser Asp Leu Asn Ala Val Lys Ser Leu Gly Thr Pro Glu Glu 
                85                  90                  95      


Ser Cys Arg Trp Asn Thr Glu Phe Leu Tyr Thr Leu His Pro Val Ser 
            100                 105                 110         


Pro Phe Ile Asn Ile Leu Tyr Ser Tyr Gly Trp Asn Gly Arg Met His 
        115                 120                 125             


Val His Ala Lys His Leu Asn Lys Ile Tyr Glu Val Lys Lys Gln Arg 
    130                 135                 140                 


Gly Lys Ile Leu Leu Gly Leu Ser Arg Leu Pro Leu Ile Ser Val Ala 
145                 150                 155                 160 


Leu Val Gln Gly Trp Ala Leu Gly Gly Gly Ala Glu Phe Thr Thr Ala 
                165                 170                 175     


Cys Asp Phe Arg Leu Met Thr Pro Glu Ser Lys Ile Arg Phe Val His 
            180                 185                 190         


Lys Glu Met Gly Ile Ile Pro Ser Trp Gly Gly Thr Thr Arg Leu Val 
        195                 200                 205             


Glu Ile Ile Gly Ser Arg Gln Ala Leu Lys Val Leu Ser Gly Ala Leu 
    210                 215                 220                 


Lys Leu Asp Ser Lys Asn Ala Leu Asn Ile Gly Met Val Glu Glu Val 
225                 230                 235                 240 


Leu Gln Ser Ser Asp Glu Thr Lys Ser Leu Glu Glu Ala Gln Glu 
                245                 250                 255 


<210>  4513
<211>  567
<212>  PRT
<213>  Homo Sapiens

<400>  4513

Met Gly Thr Thr Ala Arg Ala Ala Leu Val Leu Thr Tyr Leu Ala Val 
1               5                   10                  15      


Ala Ser Ala Ala Ser Glu Gly Gly Phe Thr Ala Thr Gly Gln Arg Gln 
            20                  25                  30          


Leu Arg Pro Glu His Phe Gln Glu Val Gly Tyr Ala Ala Pro Pro Ser 
        35                  40                  45              


Pro Pro Leu Ser Arg Ser Leu Pro Met Asp His Pro Asp Ser Ser Gln 
    50                  55                  60                  


His Gly Pro Pro Phe Glu Gly Gln Ser Gly Lys Glu Gly Arg Gly Pro 
65                  70                  75                  80  


Arg Pro His Ser Gln Pro Trp Leu Gly Glu Arg Val Gly Cys Ser His 
                85                  90                  95      


Ile Pro Pro Ser Ile Val Gln Pro Pro Pro Ser Gln Glu Ala Thr Pro 
            100                 105                 110         


Leu Gln Gln Glu Lys Leu Leu Pro Ala Gln Leu Pro Ala Glu Lys Glu 
        115                 120                 125             


Val Gly Pro Pro Leu Pro Gln Glu Ala Val Pro Leu Gln Lys Glu Leu 
    130                 135                 140                 


Pro Ser Leu Gln His Pro Asn Glu Gln Lys Glu Gly Thr Pro Ala Pro 
145                 150                 155                 160 


Phe Gly Asp Gln Ser His Pro Glu Pro Glu Ser Trp Asn Ala Ala Gln 
                165                 170                 175     


His Cys Gln Gln Asp Arg Ser Gln Gly Gly Trp Gly His Arg Leu Asp 
            180                 185                 190         


Gly Phe Pro Pro Gly Arg Pro Ser Pro Asp Asn Leu Asn Gln Ile Cys 
        195                 200                 205             


Leu Pro Asn Arg Gln His Val Val Tyr Gly Pro Trp Asn Leu Pro Gln 
    210                 215                 220                 


Ser Ser Tyr Ser His Leu Thr Arg Gln Gly Glu Thr Leu Asn Phe Leu 
225                 230                 235                 240 


Glu Ile Gly Tyr Ser Arg Cys Cys His Cys Arg Ser His Thr Asn Arg 
                245                 250                 255     


Leu Glu Cys Ala Lys Leu Val Trp Glu Glu Ala Met Ser Arg Phe Cys 
            260                 265                 270         


Glu Ala Glu Phe Ser Val Lys Thr Arg Pro His Trp Cys Cys Thr Arg 
        275                 280                 285             


Gln Gly Glu Ala Arg Phe Ser Cys Phe Gln Glu Glu Ala Pro Gln Pro 
    290                 295                 300                 


His Tyr Gln Leu Arg Ala Cys Pro Ser His Gln Pro Asp Ile Ser Ser 
305                 310                 315                 320 


Gly Leu Glu Leu Pro Phe Pro Pro Gly Val Pro Thr Leu Asp Asn Ile 
                325                 330                 335     


Lys Asn Ile Cys His Leu Arg Arg Phe Arg Ser Val Pro Arg Asn Leu 
            340                 345                 350         


Pro Ala Thr Asp Pro Leu Gln Arg Glu Leu Leu Ala Leu Ile Gln Leu 
        355                 360                 365             


Glu Arg Glu Phe Gln Arg Cys Cys Arg Gln Gly Asn Asn His Thr Cys 
    370                 375                 380                 


Thr Trp Lys Ala Trp Glu Asp Thr Leu Asp Lys Tyr Cys Asp Arg Glu 
385                 390                 395                 400 


Tyr Ala Val Lys Thr His His His Leu Cys Cys Arg His Pro Pro Ser 
                405                 410                 415     


Pro Thr Arg Asp Glu Cys Phe Ala Arg Arg Ala Pro Tyr Pro Asn Tyr 
            420                 425                 430         


Asp Arg Asp Ile Leu Thr Ile Asp Ile Gly Arg Val Thr Pro Asn Leu 
        435                 440                 445             


Met Gly His Leu Cys Gly Asn Gln Arg Val Leu Thr Lys His Lys His 
    450                 455                 460                 


Ile Pro Gly Leu Ile His Asn Met Thr Ala Arg Cys Cys Asp Leu Pro 
465                 470                 475                 480 


Phe Pro Glu Gln Ala Cys Cys Ala Glu Glu Glu Lys Leu Thr Phe Ile 
                485                 490                 495     


Asn Asp Leu Cys Gly Pro Arg Arg Asn Ile Trp Arg Asp Pro Ala Leu 
            500                 505                 510         


Cys Cys Tyr Leu Ser Pro Gly Asp Glu Gln Val Asn Cys Phe Asn Ile 
        515                 520                 525             


Asn Tyr Leu Arg Asn Val Ala Leu Val Ser Gly Asp Thr Glu Asn Ala 
    530                 535                 540                 


Lys Gly Gln Gly Glu Gln Gly Ser Thr Gly Gly Thr Asn Ile Ser Ser 
545                 550                 555                 560 


Thr Ser Glu Pro Lys Glu Glu 
                565         


<210>  4514
<211>  415
<212>  PRT
<213>  Homo Sapiens

<400>  4514

Met Gly Thr Thr Ala Arg Ala Ala Leu Val Leu Thr Tyr Leu Ala Val 
1               5                   10                  15      


Ala Ser Ala Ala Ser Glu Gly Gly Phe Thr Ala Thr Gly Gln Arg Gln 
            20                  25                  30          


Leu Arg Pro Glu His Phe Gln Glu Val Gly Tyr Ala Ala Pro Pro Ser 
        35                  40                  45              


Pro Pro Leu Ser Arg Ser Leu Pro Met Asp His Pro Asp Ser Ser Gln 
    50                  55                  60                  


His Gly Pro Pro Phe Glu Gly Gln Ser Gln Val Gln Pro Pro Pro Ser 
65                  70                  75                  80  


Gln Glu Ala Thr Pro Leu Gln Gln Glu Lys Leu Leu Pro Ala Gln Leu 
                85                  90                  95      


Pro Ala Glu Lys Glu Val Gly Pro Pro Leu Pro Gln Glu Ala Val Pro 
            100                 105                 110         


Leu Gln Lys Glu Leu Pro Ser Leu Gln His Pro Asn Glu Gln Lys Glu 
        115                 120                 125             


Gly Thr Pro Ala Pro Phe Gly Asp Gln Ser His Pro Glu Pro Glu Ser 
    130                 135                 140                 


Trp Asn Ala Ala Gln His Cys Gln Gln Asp Arg Ser Gln Gly Gly Trp 
145                 150                 155                 160 


Gly His Arg Leu Asp Gly Phe Pro Pro Gly Arg Pro Ser Pro Asp Asn 
                165                 170                 175     


Leu Asn Gln Ile Cys Leu Pro Asn Arg Gln His Val Val Tyr Gly Pro 
            180                 185                 190         


Trp Asn Leu Pro Gln Ser Ser Tyr Ser His Leu Thr Arg Gln Gly Glu 
        195                 200                 205             


Thr Leu Asn Phe Leu Glu Ile Gly Tyr Ser Arg Cys Cys His Cys Arg 
    210                 215                 220                 


Ser His Thr Asn Arg Leu Glu Cys Ala Lys Leu Val Trp Glu Asp Thr 
225                 230                 235                 240 


Leu Asp Lys Tyr Cys Asp Arg Glu Tyr Ala Val Lys Thr His His His 
                245                 250                 255     


Leu Cys Cys Arg His Pro Pro Ser Pro Thr Arg Asp Glu Cys Phe Ala 
            260                 265                 270         


Arg Arg Ala Pro Tyr Pro Asn Tyr Asp Arg Asp Ile Leu Thr Ile Asp 
        275                 280                 285             


Ile Gly Arg Val Thr Pro Asn Leu Met Gly His Leu Cys Gly Asn Gln 
    290                 295                 300                 


Arg Val Leu Thr Lys His Lys His Ile Pro Gly Leu Ile His Asn Met 
305                 310                 315                 320 


Thr Ala Arg Cys Cys Asp Leu Pro Phe Pro Glu Gln Ala Cys Cys Ala 
                325                 330                 335     


Glu Glu Glu Lys Leu Thr Phe Ile Asn Asp Leu Cys Gly Pro Arg Arg 
            340                 345                 350         


Asn Ile Trp Arg Asp Pro Ala Leu Cys Cys Tyr Leu Ser Pro Gly Asp 
        355                 360                 365             


Glu Gln Val Asn Cys Phe Asn Ile Asn Tyr Leu Arg Asn Val Ala Leu 
    370                 375                 380                 


Val Ser Gly Asp Thr Glu Asn Ala Lys Gly Gln Gly Glu Gln Gly Ser 
385                 390                 395                 400 


Thr Gly Gly Thr Asn Ile Ser Ser Thr Ser Glu Pro Lys Glu Glu 
                405                 410                 415 


<210>  4515
<211>  540
<212>  PRT
<213>  Homo Sapiens

<400>  4515

Met Gly Thr Thr Ala Arg Ala Ala Leu Val Leu Thr Tyr Leu Ala Val 
1               5                   10                  15      


Ala Ser Ala Ala Ser Glu Gly Gly Phe Thr Ala Thr Gly Gln Arg Gln 
            20                  25                  30          


Leu Arg Pro Glu His Phe Gln Glu Val Gly Tyr Ala Ala Pro Pro Ser 
        35                  40                  45              


Pro Pro Leu Ser Arg Ser Leu Pro Met Asp His Pro Asp Ser Ser Gln 
    50                  55                  60                  


His Gly Pro Pro Phe Glu Gly Gln Ser Gln Val Gln Pro Pro Pro Ser 
65                  70                  75                  80  


Gln Glu Ala Thr Pro Leu Gln Gln Glu Lys Leu Leu Pro Ala Gln Leu 
                85                  90                  95      


Pro Ala Glu Lys Glu Val Gly Pro Pro Leu Pro Gln Glu Ala Val Pro 
            100                 105                 110         


Leu Gln Lys Glu Leu Pro Ser Leu Gln His Pro Asn Glu Gln Lys Glu 
        115                 120                 125             


Gly Thr Pro Ala Pro Phe Gly Asp Gln Ser His Pro Glu Pro Glu Ser 
    130                 135                 140                 


Trp Asn Ala Ala Gln His Cys Gln Gln Asp Arg Ser Gln Gly Gly Trp 
145                 150                 155                 160 


Gly His Arg Leu Asp Gly Phe Pro Pro Gly Arg Pro Ser Pro Asp Asn 
                165                 170                 175     


Leu Asn Gln Ile Cys Leu Pro Asn Arg Gln His Val Val Tyr Gly Pro 
            180                 185                 190         


Trp Asn Leu Pro Gln Ser Ser Tyr Ser His Leu Thr Arg Gln Gly Glu 
        195                 200                 205             


Thr Leu Asn Phe Leu Glu Ile Gly Tyr Ser Arg Cys Cys His Cys Arg 
    210                 215                 220                 


Ser His Thr Asn Arg Leu Glu Cys Ala Lys Leu Val Trp Glu Glu Ala 
225                 230                 235                 240 


Met Ser Arg Phe Cys Glu Ala Glu Phe Ser Val Lys Thr Arg Pro His 
                245                 250                 255     


Trp Cys Cys Thr Arg Gln Gly Glu Ala Arg Phe Ser Cys Phe Gln Glu 
            260                 265                 270         


Glu Ala Pro Gln Pro His Tyr Gln Leu Arg Ala Cys Pro Ser His Gln 
        275                 280                 285             


Pro Asp Ile Ser Ser Gly Leu Glu Leu Pro Phe Pro Pro Gly Val Pro 
    290                 295                 300                 


Thr Leu Asp Asn Ile Lys Asn Ile Cys His Leu Arg Arg Phe Arg Ser 
305                 310                 315                 320 


Val Pro Arg Asn Leu Pro Ala Thr Asp Pro Leu Gln Arg Glu Leu Leu 
                325                 330                 335     


Ala Leu Ile Gln Leu Glu Arg Glu Phe Gln Arg Cys Cys Arg Gln Gly 
            340                 345                 350         


Asn Asn His Thr Cys Thr Trp Lys Ala Trp Glu Asp Thr Leu Asp Lys 
        355                 360                 365             


Tyr Cys Asp Arg Glu Tyr Ala Val Lys Thr His His His Leu Cys Cys 
    370                 375                 380                 


Arg His Pro Pro Ser Pro Thr Arg Asp Glu Cys Phe Ala Arg Arg Ala 
385                 390                 395                 400 


Pro Tyr Pro Asn Tyr Asp Arg Asp Ile Leu Thr Ile Asp Ile Gly Arg 
                405                 410                 415     


Val Thr Pro Asn Leu Met Gly His Leu Cys Gly Asn Gln Arg Val Leu 
            420                 425                 430         


Thr Lys His Lys His Ile Pro Gly Leu Ile His Asn Met Thr Ala Arg 
        435                 440                 445             


Cys Cys Asp Leu Pro Phe Pro Glu Gln Ala Cys Cys Ala Glu Glu Glu 
    450                 455                 460                 


Lys Leu Thr Phe Ile Asn Asp Leu Cys Gly Pro Arg Arg Asn Ile Trp 
465                 470                 475                 480 


Arg Asp Pro Ala Leu Cys Cys Tyr Leu Ser Pro Gly Asp Glu Gln Val 
                485                 490                 495     


Asn Cys Phe Asn Ile Asn Tyr Leu Arg Asn Val Ala Leu Val Ser Gly 
            500                 505                 510         


Asp Thr Glu Asn Ala Lys Gly Gln Gly Glu Gln Gly Ser Thr Gly Gly 
        515                 520                 525             


Thr Asn Ile Ser Ser Thr Ser Glu Pro Lys Glu Glu 
    530                 535                 540 


<210>  4516
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  4516

Met Lys Ile Ala Val Leu Phe Cys Phe Phe Leu Leu Ile Ile Phe Gln 
1               5                   10                  15      


Thr Asp Phe Gly Lys Asn Glu Glu Ile Pro Arg Lys Gln Arg Arg Lys 
            20                  25                  30          


Ile Tyr His Arg Arg Leu Arg Lys Ser Ser Thr Ser His Lys His Arg 
        35                  40                  45              


Ser Asn Arg Gln Leu Gly Ile Gln Gln Thr Thr Val Phe Thr Pro Val 
    50                  55                  60                  


Ala Arg Leu Pro Ile Val Asn Phe Asp Tyr Ser Met Glu Glu Lys Phe 
65                  70                  75                  80  


Glu Ser Phe Ser Ser Phe Pro Gly Val Glu Ser Ser Tyr Asn Val Leu 
                85                  90                  95      


Pro Gly Lys Lys Gly His Cys Leu Val Lys Gly Ile Thr Met Tyr Asn 
            100                 105                 110         


Lys Ala Val Trp Ser Pro Glu Pro Cys Thr Thr Cys Leu Cys Ser Asp 
        115                 120                 125             


Gly Arg Val Leu Cys Asp Glu Thr Met Cys His Pro Gln Arg Cys Pro 
    130                 135                 140                 


Gln Thr Val Ile Pro Glu Gly Glu Cys Cys Pro Val Cys Ser Ala Thr 
145                 150                 155                 160 


<210>  4517
<211>  643
<212>  PRT
<213>  Homo Sapiens

<400>  4517

Met Lys Ile Ala Val Leu Phe Cys Phe Phe Leu Leu Ile Ile Phe Gln 
1               5                   10                  15      


Thr Asp Phe Gly Lys Asn Glu Glu Ile Pro Arg Lys Gln Arg Arg Lys 
            20                  25                  30          


Ile Tyr His Arg Arg Leu Arg Lys Ser Ser Thr Ser His Lys His Arg 
        35                  40                  45              


Ser Asn Arg Gln Leu Gly Ile Gln Gln Thr Thr Val Phe Thr Pro Val 
    50                  55                  60                  


Ala Arg Leu Pro Ile Val Asn Phe Asp Tyr Ser Met Glu Glu Lys Phe 
65                  70                  75                  80  


Glu Ser Phe Ser Ser Phe Pro Gly Val Glu Ser Ser Tyr Asn Val Leu 
                85                  90                  95      


Pro Gly Lys Lys Gly His Cys Leu Val Lys Gly Ile Thr Met Tyr Asn 
            100                 105                 110         


Lys Ala Val Trp Ser Pro Glu Pro Cys Thr Thr Cys Leu Cys Ser Asp 
        115                 120                 125             


Gly Arg Val Leu Cys Asp Glu Thr Met Cys His Pro Gln Arg Cys Pro 
    130                 135                 140                 


Gln Thr Val Ile Pro Glu Gly Glu Cys Cys Pro Val Cys Ser Ala Thr 
145                 150                 155                 160 


Glu Gln Arg Glu Pro Thr Asn Leu Leu His Lys Gln Leu Pro Pro Pro 
                165                 170                 175     


Gln Val Gly Met Asp Arg Ile Val Arg Lys Glu Ala Leu Gln Ser Glu 
            180                 185                 190         


Glu Asp Glu Glu Val Lys Glu Glu Asp Thr Glu Gln Lys Arg Glu Thr 
        195                 200                 205             


Pro Glu Ser Arg Asn Gln Gly Gln Leu Tyr Ser Glu Gly Asp Ser Arg 
    210                 215                 220                 


Gly Gly Asp Arg Lys Gln Arg Pro Gly Glu Glu Arg Arg Leu Ala His 
225                 230                 235                 240 


Gln Gln Gln Arg Gln Gly Arg Glu Glu Glu Glu Asp Glu Glu Glu Glu 
                245                 250                 255     


Gly Glu Glu Gly Glu Glu Asp Glu Glu Asp Glu Glu Asp Pro Val Arg 
            260                 265                 270         


Gly Asp Met Phe Arg Met Pro Ser Arg Ser Pro Leu Pro Ala Pro Pro 
        275                 280                 285             


Arg Gly Thr Leu Arg Leu Pro Ser Gly Cys Ser Leu Ser Tyr Arg Thr 
    290                 295                 300                 


Ile Ser Cys Ile Asn Ala Met Leu Thr Gln Ile Pro Pro Leu Thr Ala 
305                 310                 315                 320 


Pro Gln Ile Thr Ser Leu Glu Leu Thr Gly Asn Ser Ile Ala Ser Ile 
                325                 330                 335     


Pro Asp Glu Ala Phe Asn Gly Leu Pro Asn Leu Glu Arg Leu Asp Leu 
            340                 345                 350         


Ser Lys Asn Asn Ile Thr Ser Ser Gly Ile Gly Pro Lys Ala Phe Lys 
        355                 360                 365             


Leu Leu Lys Lys Leu Met Arg Leu Asn Met Asp Gly Asn Asn Leu Ile 
    370                 375                 380                 


Gln Ile Pro Ser Gln Leu Pro Ser Thr Leu Glu Glu Leu Lys Val Asn 
385                 390                 395                 400 


Glu Asn Asn Leu Gln Ala Ile Asp Glu Glu Ser Leu Ser Asp Leu Asn 
                405                 410                 415     


Gln Leu Val Thr Leu Glu Leu Glu Gly Asn Asn Leu Ser Glu Ala Asn 
            420                 425                 430         


Val Asn Pro Leu Ala Phe Lys Pro Leu Lys Ser Leu Ala Tyr Leu Arg 
        435                 440                 445             


Leu Gly Lys Asn Lys Phe Arg Ile Ile Pro Gln Gly Leu Pro Gly Ser 
    450                 455                 460                 


Ile Glu Glu Leu Tyr Leu Glu Asn Asn Gln Ile Glu Glu Ile Thr Glu 
465                 470                 475                 480 


Ile Cys Phe Asn His Thr Arg Lys Ile Asn Val Ile Val Leu Arg Tyr 
                485                 490                 495     


Asn Lys Ile Glu Glu Asn Arg Ile Ala Pro Leu Ala Trp Ile Asn Gln 
            500                 505                 510         


Glu Asn Leu Glu Ser Ile Asp Leu Ser Tyr Asn Lys Leu Tyr His Val 
        515                 520                 525             


Pro Ser Tyr Leu Pro Lys Ser Leu Leu His Leu Val Leu Leu Gly Asn 
    530                 535                 540                 


Gln Ile Glu Arg Ile Pro Gly Tyr Val Phe Gly His Met Glu Pro Gly 
545                 550                 555                 560 


Leu Glu Tyr Leu Tyr Leu Ser Phe Asn Lys Leu Ala Asp Asp Gly Met 
                565                 570                 575     


Asp Arg Val Ser Phe Tyr Gly Ala Tyr His Ser Leu Arg Glu Leu Phe 
            580                 585                 590         


Leu Asp His Asn Asp Leu Lys Ser Ile Pro Pro Gly Ile Gln Glu Met 
        595                 600                 605             


Lys Ala Leu His Phe Leu Arg Leu Asn Asn Asn Lys Ile Arg Cys Val 
    610                 615                 620                 


Ser Asp Ala Val Leu Glu Thr Val Thr Asn Arg Ser Asp Val Ala Phe 
625                 630                 635                 640 


Pro Leu Trp 
            


<210>  4518
<211>  164
<212>  PRT
<213>  Homo Sapiens

<400>  4518

Met Lys Ile Ala Val Leu Phe Cys Phe Phe Leu Leu Ile Ile Phe Gln 
1               5                   10                  15      


Thr Asp Phe Gly Lys Asn Glu Glu Ile Pro Arg Lys Gln Arg Arg Lys 
            20                  25                  30          


Ile Tyr His Arg Arg Leu Arg Lys Ser Ser Thr Ser His Lys His Arg 
        35                  40                  45              


Ser Asn Arg Gln Leu Gly Ile Gln Gln Thr Thr Val Phe Thr Pro Val 
    50                  55                  60                  


Ala Arg Leu Pro Ile Val Asn Phe Asp Tyr Ser Met Glu Glu Lys Phe 
65                  70                  75                  80  


Glu Ser Phe Ser Ser Phe Pro Gly Val Glu Ser Ser Tyr Asn Val Leu 
                85                  90                  95      


Pro Gly Lys Lys Gly His Cys Leu Val Lys Gly Ile Thr Met Tyr Asn 
            100                 105                 110         


Lys Ala Val Trp Ser Pro Glu Pro Cys Thr Thr Cys Leu Cys Ser Asp 
        115                 120                 125             


Gly Arg Val Leu Cys Asp Glu Thr Met Cys His Pro Gln Arg Cys Pro 
    130                 135                 140                 


Gln Thr Val Ile Pro Glu Gly Glu Cys Cys Pro Val Cys Ser Ala Thr 
145                 150                 155                 160 


Gly Thr Glu Ile 
                


<210>  4519
<211>  699
<212>  PRT
<213>  Homo Sapiens

<400>  4519

Met Lys Ile Ala Val Leu Phe Cys Phe Phe Leu Leu Ile Ile Phe Gln 
1               5                   10                  15      


Thr Asp Phe Gly Lys Asn Glu Glu Ile Pro Arg Lys Gln Arg Arg Lys 
            20                  25                  30          


Ile Tyr His Arg Arg Leu Arg Lys Ser Ser Thr Ser His Lys His Arg 
        35                  40                  45              


Ser Asn Arg Gln Leu Gly Ile Gln Gln Thr Thr Val Phe Thr Pro Val 
    50                  55                  60                  


Ala Arg Leu Pro Ile Val Asn Phe Asp Tyr Ser Met Glu Glu Lys Phe 
65                  70                  75                  80  


Glu Ser Phe Ser Ser Phe Pro Gly Val Glu Ser Ser Tyr Asn Val Leu 
                85                  90                  95      


Pro Gly Lys Lys Gly His Cys Leu Val Lys Gly Ile Thr Met Tyr Asn 
            100                 105                 110         


Lys Ala Val Trp Ser Pro Glu Pro Cys Thr Thr Cys Leu Cys Ser Asp 
        115                 120                 125             


Gly Arg Val Leu Cys Asp Glu Thr Met Cys His Pro Gln Arg Cys Pro 
    130                 135                 140                 


Gln Thr Val Ile Pro Glu Gly Glu Cys Cys Pro Val Cys Ser Ala Thr 
145                 150                 155                 160 


Val Ser Tyr Ser Leu Leu Ser Gly Ile Ala Leu Asn Asp Arg Asn Glu 
                165                 170                 175     


Phe Ser Gly Asp Ser Ser Glu Gln Arg Glu Pro Thr Asn Leu Leu His 
            180                 185                 190         


Lys Gln Leu Pro Pro Pro Gln Val Gly Met Asp Arg Ile Val Arg Lys 
        195                 200                 205             


Glu Ala Leu Gln Ser Glu Glu Asp Glu Glu Val Lys Glu Glu Asp Thr 
    210                 215                 220                 


Glu Gln Lys Arg Glu Thr Pro Glu Ser Arg Asn Gln Gly Gln Leu Tyr 
225                 230                 235                 240 


Ser Glu Gly Asp Ser Arg Gly Gly Asp Arg Lys Gln Arg Pro Gly Glu 
                245                 250                 255     


Glu Arg Arg Leu Ala His Gln Gln Gln Arg Gln Gly Arg Glu Glu Glu 
            260                 265                 270         


Glu Asp Glu Glu Glu Glu Gly Glu Glu Gly Glu Glu Asp Glu Glu Asp 
        275                 280                 285             


Glu Glu Asp Pro Val Arg Gly Asp Met Phe Arg Met Pro Ser Arg Ser 
    290                 295                 300                 


Pro Leu Pro Ala Pro Pro Arg Gly Thr Leu Arg Leu Pro Ser Gly Cys 
305                 310                 315                 320 


Ser Leu Ser Tyr Arg Thr Ile Ser Cys Ile Asn Ala Met Leu Thr Gln 
                325                 330                 335     


Ile Pro Pro Leu Thr Ala Pro Gln Ile Thr Ser Leu Glu Leu Thr Gly 
            340                 345                 350         


Asn Ser Ile Ala Ser Ile Pro Asp Glu Ala Phe Asn Gly Leu Pro Asn 
        355                 360                 365             


Leu Glu Arg Leu Asp Leu Ser Lys Asn Asn Ile Thr Ser Ser Gly Ile 
    370                 375                 380                 


Gly Pro Lys Ala Phe Lys Leu Leu Lys Lys Leu Met Arg Leu Asn Met 
385                 390                 395                 400 


Asp Gly Asn Asn Leu Ile Gln Ile Pro Ser Gln Leu Pro Ser Thr Leu 
                405                 410                 415     


Glu Glu Leu Lys Val Asn Glu Asn Asn Leu Gln Ala Ile Asp Glu Glu 
            420                 425                 430         


Ser Leu Ser Asp Leu Asn Gln Leu Val Thr Leu Glu Leu Glu Gly Asn 
        435                 440                 445             


Asn Leu Ser Glu Ala Asn Val Asn Pro Leu Ala Phe Lys Pro Leu Lys 
    450                 455                 460                 


Ser Leu Ala Tyr Leu Arg Leu Gly Lys Asn Lys Phe Arg Ile Ile Pro 
465                 470                 475                 480 


Gln Gly Leu Pro Gly Ser Ile Glu Glu Leu Tyr Leu Glu Asn Asn Gln 
                485                 490                 495     


Ile Glu Glu Ile Thr Glu Ile Cys Phe Asn His Thr Arg Lys Ile Asn 
            500                 505                 510         


Val Ile Val Leu Arg Tyr Asn Lys Ile Glu Glu Asn Arg Ile Ala Pro 
        515                 520                 525             


Leu Ala Trp Ile Asn Gln Glu Asn Leu Glu Ser Ile Asp Leu Ser Tyr 
    530                 535                 540                 


Asn Lys Leu Tyr His Val Pro Ser Tyr Leu Pro Lys Ser Leu Leu His 
545                 550                 555                 560 


Leu Val Leu Leu Gly Asn Gln Ile Glu Arg Ile Pro Gly Tyr Val Phe 
                565                 570                 575     


Gly His Met Glu Pro Gly Leu Glu Tyr Leu Tyr Leu Ser Phe Asn Lys 
            580                 585                 590         


Leu Ala Asp Asp Gly Met Asp Arg Val Ser Phe Tyr Gly Ala Tyr His 
        595                 600                 605             


Ser Leu Arg Glu Leu Phe Leu Asp His Asn Asp Leu Lys Ser Ile Pro 
    610                 615                 620                 


Pro Gly Ile Gln Glu Met Lys Ala Leu His Phe Leu Arg Leu Asn Asn 
625                 630                 635                 640 


Asn Lys Ile Arg Asn Ile Leu Pro Glu Glu Ile Cys Asn Ala Glu Glu 
                645                 650                 655     


Asp Asp Asp Ser Asn Leu Glu His Leu His Leu Glu Asn Asn Tyr Ile 
            660                 665                 670         


Lys Ile Arg Glu Ile Pro Ser Tyr Thr Phe Ser Cys Ile Arg Ser Tyr 
        675                 680                 685             


Ser Ser Ile Val Leu Lys Pro Gln Asn Ile Lys 
    690                 695                 


<210>  4520
<211>  102
<212>  PRT
<213>  Homo Sapiens

<400>  4520

Met Arg Glu Tyr Gly Val Glu Arg Asp Leu Ala Val Tyr Asn Gln Leu 
1               5                   10                  15      


Leu Asn Ile Phe Pro Lys Glu Val Phe Arg Pro Arg Asn Ile Ile Gln 
            20                  25                  30          


Arg Ile Phe Val His Tyr Pro Arg Gln Gln Glu Cys Gly Ile Ala Val 
        35                  40                  45              


Leu Glu Gln Met Glu Asn His Gly Val Met Pro Asn Lys Glu Thr Glu 
    50                  55                  60                  


Phe Leu Leu Ile Gln Ile Phe Gly Arg Lys Ser Tyr Pro Met Leu Lys 
65                  70                  75                  80  


Leu Val Arg Leu Lys Leu Trp Phe Pro Arg Phe Met Asn Val Asn Pro 
                85                  90                  95      


Phe Pro Val Pro Arg Asp 
            100         


<210>  4521
<211>  223
<212>  PRT
<213>  Homo Sapiens

<400>  4521

Met Arg Glu Tyr Gly Val Glu Arg Asp Leu Ala Val Tyr Asn Gln Leu 
1               5                   10                  15      


Leu Asn Ile Phe Pro Lys Glu Val Phe Arg Pro Arg Asn Ile Ile Gln 
            20                  25                  30          


Arg Ile Phe Val His Tyr Pro Arg Gln Gln Glu Cys Gly Ile Ala Val 
        35                  40                  45              


Leu Glu Gln Met Glu Asn His Gly Val Met Pro Asn Lys Glu Thr Glu 
    50                  55                  60                  


Phe Leu Leu Ile Gln Ile Phe Gly Arg Lys Ser Tyr Pro Met Leu Lys 
65                  70                  75                  80  


Leu Val Arg Leu Lys Leu Trp Phe Pro Arg Phe Met Asn Val Asn Pro 
                85                  90                  95      


Phe Pro Val Pro Arg Asp Leu Pro Gln Asp Pro Val Glu Leu Ala Met 
            100                 105                 110         


Phe Gly Leu Arg His Met Glu Pro Asp Leu Ser Ala Arg Val Thr Ile 
        115                 120                 125             


Tyr Gln Val Pro Leu Pro Lys Asp Ser Thr Gly Ala Ala Asp Pro Pro 
    130                 135                 140                 


Gln Pro His Ile Val Gly Ile Gln Ser Pro Asp Gln Gln Ala Ala Leu 
145                 150                 155                 160 


Ala Arg His Asn Pro Ala Arg Pro Val Phe Val Glu Gly Pro Phe Ser 
                165                 170                 175     


Leu Trp Leu Arg Asn Lys Cys Val Tyr Tyr His Ile Leu Arg Ala Asp 
            180                 185                 190         


Leu Leu Pro Pro Glu Glu Arg Glu Val Glu Glu Thr Pro Glu Glu Trp 
        195                 200                 205             


Asn Leu Tyr Tyr Pro Met Gln Leu Asp Leu Glu Tyr Val Arg Ser 
    210                 215                 220             


<210>  4522
<211>  267
<212>  PRT
<213>  Homo Sapiens

<400>  4522

Met Arg Glu Tyr Gly Val Glu Arg Asp Leu Ala Val Tyr Asn Gln Leu 
1               5                   10                  15      


Leu Asn Ile Phe Pro Lys Glu Val Phe Arg Pro Arg Asn Ile Ile Gln 
            20                  25                  30          


Arg Ile Phe Val His Tyr Pro Arg Gln Gln Glu Cys Gly Ile Ala Val 
        35                  40                  45              


Leu Glu Gln Met Glu Asn His Gly Val Met Pro Asn Lys Glu Thr Glu 
    50                  55                  60                  


Phe Leu Leu Ile Gln Ile Phe Gly Arg Lys Ser Tyr Pro Met Leu Lys 
65                  70                  75                  80  


Leu Val Arg Leu Lys Leu Trp Phe Pro Arg Phe Met Asn Val Asn Pro 
                85                  90                  95      


Phe Pro Val Pro Arg Asp Leu Pro Gln Asp Pro Val Glu Leu Ala Met 
            100                 105                 110         


Phe Gly Leu Arg His Met Glu Pro Asp Leu Ser Ala Arg Val Thr Ile 
        115                 120                 125             


Tyr Gln Val Pro Leu Pro Lys Asp Ser Thr Gly Ala Ala Asp Pro Pro 
    130                 135                 140                 


Gln Pro His Ile Val Gly Lys Ser Glu Ser Met Gly Ala Ala Lys Ser 
145                 150                 155                 160 


Leu Thr Leu Pro Arg Pro Cys Gln Val Leu Ala Gly Pro Arg Leu Gly 
                165                 170                 175     


Ser Leu Gly Leu Trp Ala Glu Ser Leu Ala Gly His Arg Ala Cys Met 
            180                 185                 190         


Ser Pro His Gln Glu Ser Arg Val Pro Ile Ser Arg Pro Pro Trp Pro 
        195                 200                 205             


Ala Thr Ile Gln Pro Gly Leu Ser Leu Leu Arg Ala Pro Ser Pro Cys 
    210                 215                 220                 


Gly Ser Ala Thr Ser Val Cys Ile Thr Thr Ser Ser Glu Leu Thr Cys 
225                 230                 235                 240 


Cys Pro Arg Arg Arg Gly Lys Trp Lys Arg Arg Arg Arg Ser Gly Thr 
                245                 250                 255     


Ser Thr Thr Arg Cys Ser Trp Thr Trp Ser Met 
            260                 265         


<210>  4523
<211>  25
<212>  PRT
<213>  Homo Sapiens

<400>  4523

Met Ser Trp Val Gln Ala Thr Leu Leu Ala Arg Gly Leu Cys Arg Ala 
1               5                   10                  15      


Trp Gly Gly Thr Cys Gly Ala Ala Leu 
            20                  25  


<210>  4524
<211>  217
<212>  PRT
<213>  Homo Sapiens

<400>  4524

Met Ser Trp Val Gln Ala Thr Leu Leu Ala Arg Gly Leu Cys Arg Ala 
1               5                   10                  15      


Trp Gly Gly Thr Cys Gly Ala Ala Leu Thr Gly Thr Ser Ile Ser Gln 
            20                  25                  30          


Val Pro Leu Pro Lys Asp Ser Thr Gly Ala Ala Asp Pro Pro Gln Pro 
        35                  40                  45              


His Ile Val Gly Ile Gln Ser Pro Asp Gln Gln Ala Ala Leu Ala Arg 
    50                  55                  60                  


His Asn Pro Ala Arg Pro Val Phe Val Glu Gly Pro Phe Ser Leu Trp 
65                  70                  75                  80  


Leu Arg Asn Lys Cys Val Tyr Tyr His Ile Leu Arg Ala Asp Leu Leu 
                85                  90                  95      


Pro Pro Glu Glu Arg Glu Val Glu Glu Thr Pro Glu Glu Trp Asn Leu 
            100                 105                 110         


Tyr Tyr Pro Met Gln Leu Asp Leu Glu Tyr Val Arg Ser Gly Trp Asp 
        115                 120                 125             


Asn Tyr Glu Phe Asp Ile Asn Glu Val Glu Glu Gly Pro Val Phe Ala 
    130                 135                 140                 


Met Cys Met Ala Gly Ala His Asp Gln Ala Thr Met Ala Lys Trp Ile 
145                 150                 155                 160 


Gln Gly Leu Gln Glu Thr Asn Pro Thr Leu Ala Gln Ile Pro Val Val 
                165                 170                 175     


Phe Arg Leu Ala Gly Ser Thr Arg Glu Leu Gln Thr Ser Ser Ala Gly 
            180                 185                 190         


Leu Glu Glu Pro Pro Leu Pro Glu Asp His Gln Glu Glu Asp Asp Asn 
        195                 200                 205             


Leu Gln Arg Gln Gln Gln Gly Gln Ser 
    210                 215         


<210>  4525
<211>  82
<212>  PRT
<213>  Homo Sapiens

<400>  4525

Met Ser Trp Val Gln Ala Thr Leu Leu Ala Arg Gly Leu Cys Arg Ala 
1               5                   10                  15      


Trp Gly Gly Thr Cys Gly Ala Ala Leu Thr Gly Thr Ser Ile Ser Gln 
            20                  25                  30          


Val Pro Leu Pro Lys Asp Ser Thr Gly Ala Ala Asp Pro Pro Gln Pro 
        35                  40                  45              


His Ile Val Gly Ser Gly Arg Asp Ala Gly Gly Val Glu Pro Leu Leu 
    50                  55                  60                  


Pro Asp Ala Ala Gly Pro Gly Val Cys Glu Glu Trp Leu Gly Gln Leu 
65                  70                  75                  80  


Arg Val 
        


<210>  4526
<211>  227
<212>  PRT
<213>  Homo Sapiens

<400>  4526

Met Ser Trp Val Gln Ala Thr Leu Leu Ala Arg Gly Leu Cys Arg Ala 
1               5                   10                  15      


Trp Gly Gly Thr Cys Gly Ala Ala Leu Thr Gly Thr Ser Ile Ser Gln 
            20                  25                  30          


Val Pro Arg Arg Leu Pro Arg Gly Leu His Cys Ser Ala Ala Ala His 
        35                  40                  45              


Ser Ser Glu Gln Ser Leu Val Pro Ser Pro Pro Glu Pro Arg Gln Arg 
    50                  55                  60                  


Pro Thr Lys Ala Leu Val Pro Phe Glu Asp Leu Phe Gly Gln Ala Pro 
65                  70                  75                  80  


Gly Gly Glu Arg Asp Lys Ala Ser Phe Leu Gln Thr Val Gln Lys Phe 
                85                  90                  95      


Ala Glu His Ser Val Arg Lys Arg Gly His Ile Asp Phe Ile Tyr Leu 
            100                 105                 110         


Ala Leu Arg Lys Met Arg Glu Tyr Gly Val Glu Arg Asp Leu Ala Val 
        115                 120                 125             


Tyr Asn Gln Leu Leu Asn Ile Phe Pro Lys Glu Val Phe Arg Pro Arg 
    130                 135                 140                 


Asn Ile Ile Gln Arg Ile Phe Val His Tyr Pro Arg Gln Gln Glu Cys 
145                 150                 155                 160 


Gly Ile Ala Val Leu Glu Gln Met Glu Asn His Gly Val Met Pro Asn 
                165                 170                 175     


Lys Glu Thr Glu Phe Leu Leu Ile Gln Ile Phe Gly Arg Lys Ser Tyr 
            180                 185                 190         


Pro Met Leu Lys Leu Val Arg Leu Lys Leu Trp Phe Pro Arg Phe Met 
        195                 200                 205             


Asn Val Asn Pro Phe Pro Val Pro Arg Asp Leu Pro Gln Asp Pro Val 
    210                 215                 220                 


Glu Leu Ala 
225         


<210>  4527
<211>  296
<212>  PRT
<213>  Homo Sapiens

<400>  4527

Met Ser Trp Val Gln Ala Thr Leu Leu Ala Arg Gly Leu Cys Arg Ala 
1               5                   10                  15      


Trp Gly Gly Thr Cys Gly Ala Ala Leu Thr Gly Thr Ser Ile Ser Gln 
            20                  25                  30          


Val Pro Arg Arg Leu Pro Arg Gly Leu His Cys Ser Ala Ala Ala His 
        35                  40                  45              


Ser Ser Glu Gln Ser Leu Val Pro Ser Pro Pro Glu Pro Arg Gln Arg 
    50                  55                  60                  


Pro Thr Lys Ala Leu Val Pro Phe Glu Asp Leu Phe Gly Gln Ala Pro 
65                  70                  75                  80  


Gly Gly Glu Arg Asp Lys Ala Ser Phe Leu Gln Thr Val Gln Lys Phe 
                85                  90                  95      


Ala Glu His Ser Val Arg Lys Arg Gly His Ile Asp Phe Ile Tyr Leu 
            100                 105                 110         


Ala Leu Arg Lys Met Arg Glu Tyr Gly Val Glu Arg Asp Leu Ala Val 
        115                 120                 125             


Tyr Asn Gln Leu Leu Asn Ile Phe Pro Lys Glu Val Phe Arg Pro Arg 
    130                 135                 140                 


Asn Ile Ile Gln Arg Ile Phe Val His Tyr Pro Arg Gln Gln Glu Cys 
145                 150                 155                 160 


Gly Ile Ala Val Leu Glu Gln Met Glu Asn His Gly Val Met Pro Asn 
                165                 170                 175     


Lys Glu Thr Glu Phe Leu Leu Ile Gln Ile Phe Gly Arg Lys Ser Tyr 
            180                 185                 190         


Pro Met Leu Lys Leu Val Arg Leu Lys Leu Trp Phe Pro Arg Phe Met 
        195                 200                 205             


Asn Val Asn Pro Phe Pro Val Pro Arg Asp Leu Pro Gln Asp Pro Val 
    210                 215                 220                 


Glu Leu Ala Met Phe Gly Leu Arg His Met Glu Pro Asp Leu Ser Ala 
225                 230                 235                 240 


Arg Val Thr Ile Tyr Gln Val Pro Leu Pro Lys Asp Ser Thr Gly Ala 
                245                 250                 255     


Ala Asp Pro Pro Gln Pro His Ile Val Gly Ser Gly Arg Asp Ala Gly 
            260                 265                 270         


Gly Val Glu Pro Leu Leu Pro Asp Ala Ala Gly Pro Gly Val Cys Glu 
        275                 280                 285             


Glu Trp Leu Gly Gln Leu Arg Val 
    290                 295     


<210>  4528
<211>  431
<212>  PRT
<213>  Homo Sapiens

<400>  4528

Met Ser Trp Val Gln Ala Thr Leu Leu Ala Arg Gly Leu Cys Arg Ala 
1               5                   10                  15      


Trp Gly Gly Thr Cys Gly Ala Ala Leu Thr Gly Thr Ser Ile Ser Gln 
            20                  25                  30          


Val Pro Arg Arg Leu Pro Arg Gly Leu His Cys Ser Ala Ala Ala His 
        35                  40                  45              


Ser Ser Glu Gln Ser Leu Val Pro Ser Pro Pro Glu Pro Arg Gln Arg 
    50                  55                  60                  


Pro Thr Lys Ala Leu Val Pro Phe Glu Asp Leu Phe Gly Gln Ala Pro 
65                  70                  75                  80  


Gly Gly Glu Arg Asp Lys Ala Ser Phe Leu Gln Thr Val Gln Lys Phe 
                85                  90                  95      


Ala Glu His Ser Val Arg Lys Arg Gly His Ile Asp Phe Ile Tyr Leu 
            100                 105                 110         


Ala Leu Arg Lys Met Arg Glu Tyr Gly Val Glu Arg Asp Leu Ala Val 
        115                 120                 125             


Tyr Asn Gln Leu Leu Asn Ile Phe Pro Lys Glu Val Phe Arg Pro Arg 
    130                 135                 140                 


Asn Ile Ile Gln Arg Ile Phe Val His Tyr Pro Arg Gln Gln Glu Cys 
145                 150                 155                 160 


Gly Ile Ala Val Leu Glu Gln Met Glu Asn His Gly Val Met Pro Asn 
                165                 170                 175     


Lys Glu Thr Glu Phe Leu Leu Ile Gln Ile Phe Gly Arg Lys Ser Tyr 
            180                 185                 190         


Pro Met Leu Lys Leu Val Arg Leu Lys Leu Trp Phe Pro Arg Phe Met 
        195                 200                 205             


Asn Val Asn Pro Phe Pro Val Pro Arg Asp Leu Pro Gln Asp Pro Val 
    210                 215                 220                 


Glu Leu Ala Met Phe Gly Leu Arg His Met Glu Pro Asp Leu Ser Ala 
225                 230                 235                 240 


Arg Val Thr Ile Tyr Gln Val Pro Leu Pro Lys Asp Ser Thr Gly Ala 
                245                 250                 255     


Ala Asp Pro Pro Gln Pro His Ile Val Gly Ile Gln Ser Pro Asp Gln 
            260                 265                 270         


Gln Ala Ala Leu Ala Arg His Asn Pro Ala Arg Pro Val Phe Val Glu 
        275                 280                 285             


Gly Pro Phe Ser Leu Trp Leu Arg Asn Lys Cys Val Tyr Tyr His Ile 
    290                 295                 300                 


Leu Arg Ala Asp Leu Leu Pro Pro Glu Glu Arg Glu Val Glu Glu Thr 
305                 310                 315                 320 


Pro Glu Glu Trp Asn Leu Tyr Tyr Pro Met Gln Leu Asp Leu Glu Tyr 
                325                 330                 335     


Val Arg Ser Gly Trp Asp Asn Tyr Glu Phe Asp Ile Asn Glu Val Glu 
            340                 345                 350         


Glu Gly Pro Val Phe Ala Met Cys Met Ala Gly Ala His Asp Gln Ala 
        355                 360                 365             


Thr Met Ala Lys Trp Ile Gln Gly Leu Gln Glu Thr Asn Pro Thr Leu 
    370                 375                 380                 


Ala Gln Ile Pro Val Val Phe Arg Leu Ala Gly Ser Thr Arg Glu Leu 
385                 390                 395                 400 


Gln Thr Ser Ser Ala Gly Leu Glu Glu Pro Pro Leu Pro Glu Asp His 
                405                 410                 415     


Gln Glu Glu Asp Asp Asn Leu Gln Arg Gln Gln Gln Gly Gln Ser 
            420                 425                 430     


<210>  4529
<211>  296
<212>  PRT
<213>  Homo Sapiens

<400>  4529

Met Ser Trp Val Gln Ala Thr Leu Leu Ala Arg Gly Leu Cys Arg Ala 
1               5                   10                  15      


Trp Gly Gly Thr Cys Gly Ala Ala Leu Thr Gly Thr Ser Ile Ser Gln 
            20                  25                  30          


Val Pro Arg Arg Leu Pro Arg Gly Leu His Cys Ser Ala Ala Ala His 
        35                  40                  45              


Ser Ser Glu Gln Ser Leu Val Pro Ser Pro Pro Glu Pro Arg Gln Arg 
    50                  55                  60                  


Pro Thr Lys Ala Leu Val Pro Phe Glu Asp Leu Phe Gly Gln Ala Pro 
65                  70                  75                  80  


Gly Gly Glu Arg Asp Lys Ala Ser Phe Leu Gln Thr Val Gln Lys Phe 
                85                  90                  95      


Ala Glu His Ser Val Arg Lys Arg Gly His Ile Asp Phe Ile Tyr Leu 
            100                 105                 110         


Ala Leu Arg Lys Met Arg Glu Tyr Gly Val Glu Arg Asp Leu Ala Val 
        115                 120                 125             


Tyr Asn Gln Leu Leu Asn Ile Phe Pro Lys Glu Val Phe Arg Pro Arg 
    130                 135                 140                 


Asn Ile Ile Gln Arg Ile Phe Val His Tyr Pro Arg Gln Gln Glu Cys 
145                 150                 155                 160 


Gly Ile Ala Val Leu Glu Gln Met Glu Asn His Gly Val Met Pro Asn 
                165                 170                 175     


Lys Glu Thr Glu Phe Leu Leu Ile Gln Ile Phe Gly Arg Lys Ser Tyr 
            180                 185                 190         


Pro Met Leu Lys Leu Val Arg Leu Lys Leu Trp Phe Pro Arg Phe Met 
        195                 200                 205             


Asn Val Asn Pro Phe Pro Val Pro Arg Asp Leu Pro Gln Asp Pro Val 
    210                 215                 220                 


Glu Leu Ala Met Phe Gly Leu Arg His Met Glu Pro Asp Leu Ser Ala 
225                 230                 235                 240 


Arg Val Thr Ile Tyr Gln Val Pro Leu Pro Lys Asp Ser Thr Gly Ala 
                245                 250                 255     


Ala Asp Pro Pro Gln Pro His Ile Val Glu Leu Thr Cys Cys Pro Arg 
            260                 265                 270         


Arg Arg Gly Lys Trp Lys Arg Arg Arg Arg Ser Gly Thr Ser Thr Thr 
        275                 280                 285             


Arg Cys Ser Trp Thr Trp Ser Met 
    290                 295     


<210>  4530
<211>  59
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4530

Xaa Met Arg Glu Tyr Gly Val Glu Arg Asp Leu Ala Val Tyr Asn Gln 
1               5                   10                  15      


Leu Leu Asn Ile Phe Pro Lys Glu Val Phe Arg Pro Arg Asn Ile Ile 
            20                  25                  30          


Gln Arg Ile Phe Val His Tyr Pro Arg Gln Gln Glu Cys Gly Ile Ala 
        35                  40                  45              


Val Leu Glu Gln Met Glu Asn His Ala Gln Val 
    50                  55                  


<210>  4531
<211>  71
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4531

Xaa Val Asn Pro Phe Pro Val Pro Arg Asp Leu Pro Gln Asp Pro Val 
1               5                   10                  15      


Glu Leu Ala Met Phe Gly Leu Arg His Met Glu Pro Asp Leu Ser Ala 
            20                  25                  30          


Arg Val Thr Ile Tyr Gln Ala Pro Cys Ala Ala Pro Asp Ala Ala Arg 
        35                  40                  45              


Leu Pro Pro Gln Arg Phe Leu Cys Pro Lys Thr Gln Gln Val Gln Gln 
    50                  55                  60                  


Ile Pro Pro Ser Pro Thr Ser 
65                  70      


<210>  4532
<211>  147
<212>  PRT
<213>  Homo Sapiens

<400>  4532

Met Thr Ser Ser Leu Lys Ile Trp Gly Ile Leu Leu Ala Leu Leu Cys 
1               5                   10                  15      


Ile Leu Cys Arg Leu Cys Val Tyr Ser Asn Asn Ile Tyr Trp Arg Glu 
            20                  25                  30          


Phe Ile Lys Leu His Tyr Leu Ser Pro Ser Arg Glu Phe Lys Glu Tyr 
        35                  40                  45              


Lys Cys Asp Val Leu Met Arg Glu Lys Glu Ala Leu Lys Gly Lys Ser 
    50                  55                  60                  


Phe His Met Phe Ile Tyr Ser Leu Trp Phe Lys Ile Gln Arg Ala Cys 
65                  70                  75                  80  


Ile Asn Glu Lys Gly Ser Asp Arg Tyr Arg Asn Ala Tyr Val Trp Ala 
                85                  90                  95      


Pro Gly Ala Leu Lys Val Leu Glu Cys His Trp Glu Lys Tyr Asn Asn 
            100                 105                 110         


Arg Tyr Thr Glu Ser Arg Ser Phe Ser Tyr Ile Glu Phe His Cys Gly 
        115                 120                 125             


Val Asp Gly Tyr Val Asp Asn Ile Glu Asp Leu Arg Ile Ile Glu Pro 
    130                 135                 140                 


Ile Ser Asn 
145         


<210>  4533
<211>  147
<212>  PRT
<213>  Homo Sapiens

<400>  4533

Met Ala Ser Ser Leu Lys Ile Trp Gly Thr Leu Leu Ala Leu Leu Cys 
1               5                   10                  15      


Ile Leu Cys Thr Leu Leu Val Gln Ser Lys Glu Val Ser Trp Arg Glu 
            20                  25                  30          


Phe Met Lys Gln His Tyr Leu Ser Pro Ser Arg Glu Phe Arg Glu Tyr 
        35                  40                  45              


Lys Cys Asp Val Leu Met Arg Glu Asn Glu Ala Leu Lys Asp Lys Ser 
    50                  55                  60                  


Ser His Met Phe Ile Tyr Ile Ser Trp Tyr Lys Ile Glu His Ile Cys 
65                  70                  75                  80  


Thr Ser Asp Asn Trp Met Asp Arg Phe Arg Asn Ala Tyr Val Trp Val 
                85                  90                  95      


Gln Asn Pro Leu Lys Val Leu Lys Cys His Gln Glu Asn Ser Lys Asn 
            100                 105                 110         


Ser Tyr Thr Glu Ser Arg Ser Phe Asn Tyr Ile Glu Phe His Cys Ser 
        115                 120                 125             


Met Asp Gly Tyr Val Asp Ser Ile Glu Asp Leu Lys Met Val Glu Pro 
    130                 135                 140                 


Ile Gly Asn 
145         


<210>  4534
<211>  578
<212>  PRT
<213>  Homo Sapiens

<400>  4534

Met Pro Phe Arg Leu Leu Ile Pro Leu Gly Leu Leu Cys Ala Leu Leu 
1               5                   10                  15      


Pro Gln His His Gly Ala Pro Gly Pro Asp Gly Ser Ala Pro Asp Pro 
            20                  25                  30          


Ala His Tyr Arg Glu Arg Val Lys Ala Met Phe Tyr His Ala Tyr Asp 
        35                  40                  45              


Ser Tyr Leu Glu Asn Ala Phe Pro Phe Asp Glu Leu Arg Pro Leu Thr 
    50                  55                  60                  


Cys Asp Gly His Asp Thr Trp Gly Ser Phe Ser Leu Thr Leu Ile Asp 
65                  70                  75                  80  


Ala Leu Asp Thr Leu Leu Ile Leu Gly Asn Val Ser Glu Phe Gln Arg 
                85                  90                  95      


Val Val Glu Val Leu Gln Asp Ser Val Asp Phe Asp Ile Asp Val Asn 
            100                 105                 110         


Ala Ser Val Phe Glu Thr Asn Ile Arg Val Val Gly Gly Leu Leu Ser 
        115                 120                 125             


Ala His Leu Leu Ser Lys Lys Ala Gly Val Glu Val Glu Ala Gly Trp 
    130                 135                 140                 


Pro Cys Ser Gly Pro Leu Leu Arg Met Ala Glu Glu Ala Ala Arg Lys 
145                 150                 155                 160 


Leu Leu Pro Ala Phe Gln Thr Pro Thr Gly Met Pro Tyr Gly Thr Val 
                165                 170                 175     


Asn Leu Leu His Gly Val Asn Pro Gly Glu Thr Pro Val Thr Cys Thr 
            180                 185                 190         


Ala Gly Ile Gly Thr Phe Ile Val Glu Phe Ala Thr Leu Ser Ser Leu 
        195                 200                 205             


Thr Gly Asp Pro Val Phe Glu Asp Val Ala Arg Val Ala Leu Met Arg 
    210                 215                 220                 


Leu Trp Glu Ser Arg Ser Asp Ile Gly Leu Val Gly Asn His Ile Asp 
225                 230                 235                 240 


Val Leu Thr Gly Lys Trp Val Ala Gln Asp Ala Gly Ile Gly Ala Gly 
                245                 250                 255     


Val Asp Ser Tyr Phe Glu Tyr Leu Val Lys Gly Ala Ile Leu Leu Gln 
            260                 265                 270         


Asp Lys Lys Leu Met Ala Met Phe Leu Glu Tyr Asn Lys Ala Ile Arg 
        275                 280                 285             


Asn Tyr Thr Arg Phe Asp Asp Trp Tyr Leu Trp Val Gln Met Tyr Lys 
    290                 295                 300                 


Gly Thr Val Ser Met Pro Val Phe Gln Ser Leu Glu Ala Tyr Trp Pro 
305                 310                 315                 320 


Gly Leu Gln Ser Leu Ile Gly Asp Ile Asp Asn Ala Met Arg Thr Phe 
                325                 330                 335     


Leu Asn Tyr Tyr Thr Val Trp Lys Gln Phe Gly Gly Leu Pro Glu Phe 
            340                 345                 350         


Tyr Asn Ile Pro Gln Gly Tyr Thr Val Glu Lys Arg Glu Gly Tyr Pro 
        355                 360                 365             


Leu Arg Pro Glu Leu Ile Glu Ser Ala Met Tyr Leu Tyr Arg Ala Thr 
    370                 375                 380                 


Gly Asp Pro Thr Leu Leu Glu Leu Gly Arg Asp Ala Val Glu Ser Ile 
385                 390                 395                 400 


Glu Lys Ile Ser Lys Val Glu Cys Gly Phe Ala Thr Ile Lys Asp Leu 
                405                 410                 415     


Arg Asp His Lys Leu Asp Asn Arg Met Glu Ser Phe Phe Leu Ala Glu 
            420                 425                 430         


Thr Val Lys Tyr Leu Tyr Leu Leu Phe Asp Pro Thr Asn Phe Ile His 
        435                 440                 445             


Asn Asn Gly Ser Thr Phe Asp Ala Val Ile Thr Pro Tyr Gly Glu Cys 
    450                 455                 460                 


Ile Leu Gly Ala Gly Gly Tyr Ile Phe Asn Thr Glu Ala His Pro Ile 
465                 470                 475                 480 


Asp Pro Ala Ala Leu His Cys Cys Gln Arg Leu Lys Glu Glu Gln Trp 
                485                 490                 495     


Glu Val Glu Asp Leu Met Arg Glu Phe Tyr Ser Leu Lys Arg Ser Arg 
            500                 505                 510         


Ser Lys Phe Gln Lys Asn Thr Val Ser Ser Gly Pro Trp Glu Pro Pro 
        515                 520                 525             


Ala Arg Pro Gly Thr Leu Phe Ser Pro Glu Asn His Asp Gln Ala Arg 
    530                 535                 540                 


Glu Arg Lys Pro Ala Lys Gln Lys Val Pro Leu Leu Ser Cys Pro Ser 
545                 550                 555                 560 


Gln Pro Phe Thr Ser Lys Leu Ala Leu Leu Gly Gln Val Phe Leu Asp 
                565                 570                 575     


Ser Ser 
        


<210>  4535
<211>  541
<212>  PRT
<213>  Homo Sapiens

<400>  4535

Met Pro Phe Arg Leu Leu Ile Pro Leu Gly Leu Leu Cys Ala Leu Leu 
1               5                   10                  15      


Pro Gln His His Gly Ala Pro Gly Pro Asp Gly Ser Ala Pro Asp Pro 
            20                  25                  30          


Ala His Tyr Ser Phe Ser Leu Thr Leu Ile Asp Ala Leu Asp Thr Leu 
        35                  40                  45              


Leu Ile Leu Gly Asn Val Ser Glu Phe Gln Arg Val Val Glu Val Leu 
    50                  55                  60                  


Gln Asp Ser Val Asp Phe Asp Ile Asp Val Asn Ala Ser Val Phe Glu 
65                  70                  75                  80  


Thr Asn Ile Arg Val Val Gly Gly Leu Leu Ser Ala His Leu Leu Ser 
                85                  90                  95      


Lys Lys Ala Gly Val Glu Val Glu Ala Gly Trp Pro Cys Ser Gly Pro 
            100                 105                 110         


Leu Leu Arg Met Ala Glu Glu Ala Ala Arg Lys Leu Leu Pro Ala Phe 
        115                 120                 125             


Gln Thr Pro Thr Gly Met Pro Tyr Gly Thr Val Asn Leu Leu His Gly 
    130                 135                 140                 


Val Asn Pro Gly Glu Thr Pro Val Thr Cys Thr Ala Gly Ile Gly Thr 
145                 150                 155                 160 


Phe Ile Val Glu Phe Ala Thr Leu Ser Ser Leu Thr Gly Asp Pro Val 
                165                 170                 175     


Phe Glu Asp Val Ala Arg Val Ala Leu Met Arg Leu Trp Glu Ser Arg 
            180                 185                 190         


Ser Asp Ile Gly Leu Val Gly Asn His Ile Asp Val Leu Thr Gly Lys 
        195                 200                 205             


Trp Val Ala Gln Asp Ala Gly Ile Gly Ala Gly Val Asp Ser Tyr Phe 
    210                 215                 220                 


Glu Tyr Leu Val Lys Gly Ala Ile Leu Leu Gln Asp Lys Lys Leu Met 
225                 230                 235                 240 


Ala Met Phe Leu Glu Tyr Asn Lys Ala Ile Arg Asn Tyr Thr Arg Phe 
                245                 250                 255     


Asp Asp Trp Tyr Leu Trp Val Gln Met Tyr Lys Gly Thr Val Ser Met 
            260                 265                 270         


Pro Val Phe Gln Ser Leu Glu Ala Tyr Trp Pro Gly Leu Gln Ser Leu 
        275                 280                 285             


Ile Gly Asp Ile Asp Asn Ala Met Arg Thr Phe Leu Asn Tyr Tyr Thr 
    290                 295                 300                 


Val Trp Lys Gln Phe Gly Gly Leu Pro Glu Phe Tyr Asn Ile Pro Gln 
305                 310                 315                 320 


Gly Tyr Thr Val Glu Lys Arg Glu Gly Tyr Pro Leu Arg Pro Glu Leu 
                325                 330                 335     


Ile Glu Ser Ala Met Tyr Leu Tyr Arg Ala Thr Gly Asp Pro Thr Leu 
            340                 345                 350         


Leu Glu Leu Gly Arg Asp Ala Val Glu Ser Ile Glu Lys Ile Ser Lys 
        355                 360                 365             


Val Glu Cys Gly Phe Ala Thr Ile Lys Asp Leu Arg Asp His Lys Leu 
    370                 375                 380                 


Asp Asn Arg Met Glu Ser Phe Phe Leu Ala Glu Thr Val Lys Tyr Leu 
385                 390                 395                 400 


Tyr Leu Leu Phe Asp Pro Thr Asn Phe Ile His Asn Asn Gly Ser Thr 
                405                 410                 415     


Phe Asp Ala Val Ile Thr Pro Tyr Gly Glu Cys Ile Leu Gly Ala Gly 
            420                 425                 430         


Gly Tyr Ile Phe Asn Thr Glu Ala His Pro Ile Asp Pro Ala Ala Leu 
        435                 440                 445             


His Cys Cys Gln Arg Leu Lys Glu Glu Gln Trp Glu Val Glu Asp Leu 
    450                 455                 460                 


Met Arg Glu Phe Tyr Ser Leu Lys Arg Ser Arg Ser Lys Phe Gln Lys 
465                 470                 475                 480 


Asn Thr Val Ser Ser Gly Pro Trp Glu Pro Pro Ala Arg Pro Gly Thr 
                485                 490                 495     


Leu Phe Ser Pro Glu Asn His Asp Gln Ala Arg Glu Arg Lys Pro Ala 
            500                 505                 510         


Lys Gln Lys Val Pro Leu Leu Ser Cys Pro Ser Gln Pro Phe Thr Ser 
        515                 520                 525             


Lys Leu Ala Leu Leu Gly Gln Val Phe Leu Asp Ser Ser 
    530                 535                 540     


<210>  4536
<211>  932
<212>  PRT
<213>  Homo Sapiens

<400>  4536

Met Ser Glu Ala Gly Gly Arg Gly Cys Gly Ser Pro Val Pro Gln Arg 
1               5                   10                  15      


Ala Arg Trp Arg Leu Val Ala Ala Thr Ala Ala Phe Cys Leu Val Ser 
            20                  25                  30          


Ala Thr Ser Val Trp Thr Ala Gly Ala Glu Pro Met Ser Arg Glu Glu 
        35                  40                  45              


Lys Gln Lys Leu Gly Asn Gln Val Leu Glu Met Phe Asp His Ala Tyr 
    50                  55                  60                  


Gly Asn Tyr Met Glu His Ala Tyr Pro Ala Asp Glu Leu Met Pro Leu 
65                  70                  75                  80  


Thr Cys Arg Gly Arg Val Arg Gly Gln Glu Pro Ser Arg Gly Asp Val 
                85                  90                  95      


Asp Asp Ala Leu Gly Lys Phe Ser Leu Thr Leu Ile Asp Ser Leu Asp 
            100                 105                 110         


Thr Leu Val Val Leu Asn Lys Thr Lys Glu Phe Glu Asp Ala Val Arg 
        115                 120                 125             


Lys Val Leu Arg Asp Val Asn Leu Asp Asn Asp Val Val Val Ser Val 
    130                 135                 140                 


Phe Glu Thr Asn Ile Arg Val Leu Gly Gly Leu Leu Gly Gly His Ser 
145                 150                 155                 160 


Leu Ala Ile Met Leu Lys Glu Lys Gly Glu Tyr Met Gln Trp Tyr Asn 
                165                 170                 175     


Asp Glu Leu Leu Gln Met Ala Lys Gln Leu Gly Tyr Lys Leu Leu Pro 
            180                 185                 190         


Ala Phe Asn Thr Thr Ser Gly Leu Pro Tyr Pro Arg Ile Asn Leu Lys 
        195                 200                 205             


Phe Gly Ile Arg Lys Pro Glu Ala Arg Thr Gly Thr Glu Thr Asp Thr 
    210                 215                 220                 


Cys Thr Ala Cys Ala Gly Thr Leu Ile Leu Glu Phe Ala Ala Leu Ser 
225                 230                 235                 240 


Arg Phe Thr Gly Ala Thr Ile Phe Glu Glu Tyr Ala Arg Lys Ala Leu 
                245                 250                 255     


Asp Phe Leu Trp Glu Lys Arg Gln Arg Ser Ser Asn Leu Val Gly Val 
            260                 265                 270         


Thr Ile Asn Ile His Thr Gly Asp Trp Val Arg Lys Asp Ser Gly Val 
        275                 280                 285             


Gly Ala Gly Ile Asp Ser Tyr Tyr Glu Tyr Leu Leu Lys Ala Tyr Val 
    290                 295                 300                 


Leu Leu Gly Asp Asp Ser Phe Leu Glu Arg Phe Asn Thr His Tyr Asp 
305                 310                 315                 320 


Ala Ile Met Arg Tyr Ile Ser Gln Pro Pro Leu Leu Leu Asp Val His 
                325                 330                 335     


Ile His Lys Pro Met Leu Asn Ala Arg Thr Trp Met Asp Ala Leu Leu 
            340                 345                 350         


Ala Phe Phe Pro Gly Leu Gln Val Leu Lys Gly Asp Ile Arg Pro Ala 
        355                 360                 365             


Ile Glu Thr His Glu Met Leu Tyr Gln Val Ile Lys Lys His Asn Phe 
    370                 375                 380                 


Leu Pro Glu Ala Phe Thr Thr Asp Phe Arg Val His Trp Ala Gln His 
385                 390                 395                 400 


Pro Leu Arg Pro Glu Phe Ala Glu Ser Thr Tyr Phe Leu Tyr Lys Ala 
                405                 410                 415     


Thr Gly Asp Pro Tyr Tyr Leu Glu Val Gly Lys Thr Leu Ile Glu Asn 
            420                 425                 430         


Leu Asn Lys Tyr Ala Arg Val Pro Cys Gly Phe Ala Ala Met Lys Asp 
        435                 440                 445             


Val Arg Thr Gly Ser His Glu Asp Arg Met Asp Ser Phe Phe Leu Ala 
    450                 455                 460                 


Glu Met Phe Lys Tyr Leu Tyr Leu Leu Phe Ala Asp Lys Glu Asp Ile 
465                 470                 475                 480 


Ile Phe Asp Ile Glu Asp Tyr Ile Phe Thr Thr Glu Ala His Leu Leu 
                485                 490                 495     


Pro Leu Trp Leu Ser Thr Thr Asn Gln Ser Ile Ser Lys Lys Asn Thr 
            500                 505                 510         


Thr Ser Glu Tyr Thr Glu Leu Asp Asp Ser Asn Phe Asp Trp Thr Cys 
        515                 520                 525             


Pro Asn Thr Gln Ile Leu Phe Pro Asn Asp Pro Leu Tyr Ala Gln Ser 
    530                 535                 540                 


Ile Arg Glu Pro Leu Lys Asn Val Val Asp Lys Ser Cys Pro Arg Gly 
545                 550                 555                 560 


Ile Ile Arg Val Glu Glu Ser Phe Arg Ser Gly Ala Lys Pro Pro Leu 
                565                 570                 575     


Arg Ala Arg Asp Phe Met Ala Thr Asn Pro Glu His Leu Glu Ile Leu 
            580                 585                 590         


Lys Lys Met Gly Val Ser Leu Ile His Leu Lys Asp Gly Arg Val Gln 
        595                 600                 605             


Leu Val Gln His Ala Ile Gln Ala Ala Ser Ser Ile Asp Ala Glu Asp 
    610                 615                 620                 


Gly Leu Arg Phe Met Gln Glu Met Ile Glu Leu Ser Ser Gln Gln Gln 
625                 630                 635                 640 


Lys Glu Gln Gln Leu Pro Pro Arg Ala Val Gln Ile Val Ser His Pro 
                645                 650                 655     


Phe Phe Gly Arg Val Val Leu Thr Ala Gly Pro Ala Gln Phe Gly Leu 
            660                 665                 670         


Asp Leu Ser Lys His Lys Glu Thr Arg Gly Phe Val Ala Ser Ser Lys 
        675                 680                 685             


Pro Ser Asn Gly Cys Ser Glu Leu Thr Asn Pro Glu Ala Val Met Gly 
    690                 695                 700                 


Lys Ile Ala Leu Ile Gln Arg Gly Gln Cys Met Phe Ala Glu Lys Ala 
705                 710                 715                 720 


Arg Asn Ile Gln Asn Ala Gly Ala Ile Gly Gly Ile Val Ile Asp Asp 
                725                 730                 735     


Asn Glu Gly Ser Ser Ser Asp Thr Ala Pro Leu Phe Gln Met Ala Gly 
            740                 745                 750         


Asp Gly Lys Asp Thr Asp Asp Ile Lys Ile Pro Met Leu Phe Leu Phe 
        755                 760                 765             


Ser Lys Glu Gly Ser Ile Ile Leu Asp Ala Ile Arg Glu Tyr Glu Glu 
    770                 775                 780                 


Val Glu Val Leu Leu Ser Asp Lys Ala Lys Asp Arg Asp Pro Glu Met 
785                 790                 795                 800 


Glu Asn Glu Glu Gln Pro Ser Ser Glu Asn Asp Ser Gln Asn Gln Ser 
                805                 810                 815     


Gly Glu Gln Ile Ser Ser Ser Ser Gln Glu Val Asp Leu Val Asp Gln 
            820                 825                 830         


Glu Ser Ser Glu Glu Asn Ser Leu Asn Ser His Pro Glu Ser Leu Ser 
        835                 840                 845             


Leu Ala Asp Met Asp Asn Ala Ala Ser Ile Ser Pro Ser Glu Gln Thr 
    850                 855                 860                 


Ser Asn Pro Thr Glu Asn His Glu Thr Thr Asn Leu Asn Gly Glu Cys 
865                 870                 875                 880 


Thr Asp Leu Asp Asn Gln Leu Gln Glu Gln Ser Glu Thr Glu Glu Asp 
                885                 890                 895     


Ser Asn Pro Asn Val Ser Trp Gly Lys Lys Val Gln Pro Ile Asp Ser 
            900                 905                 910         


Ile Leu Ala Asp Trp Asn Glu Asp Ile Glu Ala Phe Glu Met Met Glu 
        915                 920                 925             


Lys Asp Glu Leu 
    930         


<210>  4537
<211>  905
<212>  PRT
<213>  Homo Sapiens

<400>  4537

Met Ser Arg Glu Glu Lys Gln Lys Leu Gly Asn Gln Val Leu Glu Met 
1               5                   10                  15      


Phe Asp His Ala Tyr Gly Asn Tyr Met Glu His Ala Tyr Pro Ala Asp 
            20                  25                  30          


Glu Leu Met Pro Leu Thr Cys Arg Gly Arg Val Arg Gly Gln Glu Pro 
        35                  40                  45              


Ser Arg Gly Asp Val Asp Asp Ala Leu Gly Lys Phe Ser Leu Thr Leu 
    50                  55                  60                  


Ile Asp Ser Leu Asp Thr Leu Val Val Leu Asn Lys Thr Lys Glu Phe 
65                  70                  75                  80  


Glu Asp Ala Val Arg Lys Val Leu Arg Asp Val Asn Leu Asp Asn Asp 
                85                  90                  95      


Val Val Val Ser Val Phe Glu Thr Asn Ile Arg Val Leu Gly Gly Leu 
            100                 105                 110         


Leu Gly Gly His Ser Leu Ala Ile Met Leu Lys Glu Lys Gly Glu Tyr 
        115                 120                 125             


Met Gln Trp Tyr Asn Asp Glu Leu Leu Gln Met Ala Lys Gln Leu Gly 
    130                 135                 140                 


Tyr Lys Leu Leu Pro Ala Phe Asn Thr Thr Ser Gly Leu Pro Tyr Pro 
145                 150                 155                 160 


Arg Ile Asn Leu Lys Phe Gly Ile Arg Lys Pro Glu Ala Arg Thr Gly 
                165                 170                 175     


Thr Glu Thr Asp Thr Cys Thr Ala Cys Ala Gly Thr Leu Ile Leu Glu 
            180                 185                 190         


Phe Ala Ala Leu Ser Arg Phe Thr Gly Ala Thr Ile Phe Glu Glu Tyr 
        195                 200                 205             


Ala Arg Lys Ala Leu Asp Phe Leu Trp Glu Lys Arg Gln Arg Ser Ser 
    210                 215                 220                 


Asn Leu Val Gly Val Thr Ile Asn Ile His Thr Gly Asp Trp Val Arg 
225                 230                 235                 240 


Lys Asp Ser Gly Val Gly Ala Gly Ile Asp Ser Tyr Tyr Glu Tyr Leu 
                245                 250                 255     


Leu Lys Ala Tyr Val Leu Leu Gly Asp Asp Ser Phe Leu Glu Arg Phe 
            260                 265                 270         


Asn Thr His Tyr Asp Ala Ile Met Arg Tyr Ile Ser Gln Pro Pro Leu 
        275                 280                 285             


Leu Leu Asp Val His Ile His Lys Pro Met Leu Asn Ala Arg Thr Trp 
    290                 295                 300                 


Met Asp Ala Leu Leu Ala Phe Phe Pro Gly Leu Gln Val Leu Lys Gly 
305                 310                 315                 320 


Asp Ile Arg Pro Ala Ile Glu Thr His Glu Met Leu Tyr Gln Val Ile 
                325                 330                 335     


Lys Lys His Asn Phe Leu Pro Glu Ala Phe Thr Thr Asp Phe Arg Val 
            340                 345                 350         


His Trp Ala Gln His Pro Leu Arg Pro Glu Phe Ala Glu Ser Thr Tyr 
        355                 360                 365             


Phe Leu Tyr Lys Ala Thr Gly Asp Pro Tyr Tyr Leu Glu Val Gly Lys 
    370                 375                 380                 


Thr Leu Ile Glu Asn Leu Asn Lys Tyr Ala Arg Val Pro Cys Gly Phe 
385                 390                 395                 400 


Ala Ala Met Lys Asp Val Arg Thr Gly Ser His Glu Asp Arg Met Asp 
                405                 410                 415     


Ser Phe Phe Leu Ala Glu Met Phe Lys Tyr Leu Tyr Leu Leu Phe Ala 
            420                 425                 430         


Asp Lys Glu Asp Ile Ile Phe Asp Ile Glu Asp Tyr Ile Phe Thr Thr 
        435                 440                 445             


Glu Ala His Leu Leu Pro Leu Trp Leu Ser Thr Thr Asn Gln Ser Ile 
    450                 455                 460                 


Ser Lys Lys Asn Thr Thr Ser Glu Tyr Thr Glu Leu Asp Asp Ser Asn 
465                 470                 475                 480 


Phe Asp Trp Thr Cys Pro Asn Thr Gln Ile Leu Phe Pro Asn Asp Pro 
                485                 490                 495     


Leu Tyr Ala Gln Ser Ile Arg Glu Pro Leu Lys Asn Val Val Asp Lys 
            500                 505                 510         


Ser Cys Pro Arg Gly Ile Ile Arg Val Glu Glu Ser Phe Arg Ser Gly 
        515                 520                 525             


Ala Lys Pro Pro Leu Arg Ala Arg Asp Phe Met Ala Thr Asn Pro Glu 
    530                 535                 540                 


His Leu Glu Ile Leu Lys Lys Met Gly Val Ser Leu Ile His Leu Lys 
545                 550                 555                 560 


Asp Gly Arg Val Gln Leu Val Gln His Ala Ile Gln Ala Ala Ser Ser 
                565                 570                 575     


Ile Asp Ala Glu Asp Gly Leu Arg Phe Met Gln Glu Met Ile Glu Leu 
            580                 585                 590         


Ser Ser Gln Gln Gln Lys Glu Gln Gln Leu Pro Pro Arg Ala Val Gln 
        595                 600                 605             


Ile Val Ser His Pro Phe Phe Gly Arg Val Val Leu Thr Ala Gly Pro 
    610                 615                 620                 


Ala Gln Phe Gly Leu Asp Leu Ser Lys His Lys Glu Thr Arg Gly Phe 
625                 630                 635                 640 


Val Ala Ser Ser Lys Pro Ser Asn Gly Cys Ser Glu Leu Thr Asn Pro 
                645                 650                 655     


Glu Ala Val Met Gly Lys Ile Ala Leu Ile Gln Arg Gly Gln Cys Met 
            660                 665                 670         


Phe Ala Glu Lys Ala Arg Asn Ile Gln Asn Ala Gly Ala Ile Gly Gly 
        675                 680                 685             


Ile Val Ile Asp Asp Asn Glu Gly Ser Ser Ser Asp Thr Ala Pro Leu 
    690                 695                 700                 


Phe Gln Met Ala Gly Asp Gly Lys Asp Thr Asp Asp Ile Lys Ile Pro 
705                 710                 715                 720 


Met Leu Phe Leu Phe Ser Lys Glu Gly Ser Ile Ile Leu Asp Ala Ile 
                725                 730                 735     


Arg Glu Tyr Glu Glu Val Glu Val Leu Leu Ser Asp Lys Ala Lys Asp 
            740                 745                 750         


Arg Ala Ala Ile Leu Lys Gly Lys Met Ile Pro Ser Tyr Ile Ile Asn 
        755                 760                 765             


Ser Asn Pro Glu Met Glu Asn Glu Glu Gln Pro Ser Ser Glu Asn Asp 
    770                 775                 780                 


Ser Gln Asn Gln Ser Gly Glu Gln Ile Ser Ser Ser Ser Gln Glu Val 
785                 790                 795                 800 


Asp Leu Val Asp Gln Glu Ser Ser Glu Glu Asn Ser Leu Asn Ser His 
                805                 810                 815     


Pro Glu Ser Leu Ser Leu Ala Asp Met Asp Asn Ala Ala Ser Ile Ser 
            820                 825                 830         


Pro Ser Glu Gln Thr Ser Asn Pro Thr Glu Asn His Glu Thr Thr Asn 
        835                 840                 845             


Leu Asn Gly Glu Cys Thr Asp Leu Asp Asn Gln Leu Gln Glu Gln Ser 
    850                 855                 860                 


Glu Thr Glu Glu Asp Ser Asn Pro Asn Val Ser Trp Gly Lys Lys Val 
865                 870                 875                 880 


Gln Pro Ile Asp Ser Ile Leu Ala Asp Trp Asn Glu Asp Ile Glu Ala 
                885                 890                 895     


Phe Glu Met Met Glu Lys Asp Glu Leu 
            900                 905 


<210>  4538
<211>  380
<212>  PRT
<213>  Homo Sapiens

<400>  4538

Val Asp Lys Ser Cys Pro Arg Gly Ile Ile Arg Val Glu Glu Ser Phe 
1               5                   10                  15      


Arg Ser Gly Ala Lys Pro Pro Leu Arg Ala Arg Asp Phe Met Ala Thr 
            20                  25                  30          


Asn Pro Glu His Leu Glu Ile Leu Lys Lys Met Gly Val Ser Leu Ile 
        35                  40                  45              


His Leu Lys Asp Gly Arg Val Gln Leu Val Gln His Ala Ile Gln Ala 
    50                  55                  60                  


Ala Ser Ser Ile Asp Ala Glu Asp Gly Leu Arg Phe Met Gln Glu Met 
65                  70                  75                  80  


Ile Glu Leu Ser Ser Gln Gln Gln Lys Glu Gln Gln Leu Pro Pro Arg 
                85                  90                  95      


Ala Val Gln Ile Val Ser His Pro Phe Phe Gly Arg Val Val Leu Thr 
            100                 105                 110         


Ala Gly Pro Ala Gln Phe Gly Leu Asp Leu Ser Lys His Lys Glu Thr 
        115                 120                 125             


Arg Gly Phe Val Ala Ser Ser Lys Pro Ser Asn Gly Cys Ser Glu Leu 
    130                 135                 140                 


Thr Asn Pro Glu Ala Val Met Gly Lys Ile Ala Leu Ile Gln Arg Gly 
145                 150                 155                 160 


Gln Cys Met Phe Ala Glu Lys Ala Arg Asn Ile Gln Asn Ala Gly Ala 
                165                 170                 175     


Ile Gly Gly Ile Val Ile Asp Asp Asn Glu Gly Ser Ser Ser Asp Thr 
            180                 185                 190         


Ala Pro Leu Phe Gln Met Ala Gly Asp Gly Lys Asp Thr Asp Asp Ile 
        195                 200                 205             


Lys Ile Pro Met Leu Phe Leu Phe Ser Lys Glu Gly Ser Ile Ile Leu 
    210                 215                 220                 


Asp Ala Ile Arg Glu Tyr Glu Glu Val Glu Val Leu Leu Ser Asp Lys 
225                 230                 235                 240 


Ala Lys Asp Arg Asp Pro Glu Met Glu Asn Glu Glu Gln Pro Ser Ser 
                245                 250                 255     


Glu Asn Asp Ser Gln Asn Gln Ser Gly Glu Gln Ile Ser Ser Ser Ser 
            260                 265                 270         


Gln Glu Val Asp Leu Val Asp Gln Glu Ser Ser Glu Glu Asn Ser Leu 
        275                 280                 285             


Asn Ser His Pro Glu Ser Leu Ser Leu Ala Asp Met Asp Asn Ala Ala 
    290                 295                 300                 


Ser Ile Ser Pro Ser Glu Gln Thr Ser Asn Pro Thr Glu Asn His Glu 
305                 310                 315                 320 


Thr Thr Asn Leu Asn Gly Glu Cys Thr Asp Leu Asp Asn Gln Leu Gln 
                325                 330                 335     


Glu Gln Ser Glu Thr Glu Glu Asp Ser Asn Pro Asn Val Ser Trp Gly 
            340                 345                 350         


Lys Lys Val Gln Pro Ile Asp Ser Ile Leu Ala Asp Trp Asn Glu Asp 
        355                 360                 365             


Ile Glu Ala Phe Glu Met Met Glu Lys Asp Glu Leu 
    370                 375                 380 


<210>  4539
<211>  480
<212>  PRT
<213>  Homo Sapiens

<400>  4539

Met Lys Arg Ser Val Ala Val Trp Leu Leu Val Gly Leu Ser Leu Gly 
1               5                   10                  15      


Val Pro Gln Phe Gly Lys Gly Asp Ile Cys Asp Pro Asn Pro Cys Glu 
            20                  25                  30          


Asn Gly Gly Ile Cys Leu Pro Gly Leu Ala Asp Gly Ser Phe Ser Cys 
        35                  40                  45              


Glu Cys Pro Asp Gly Phe Thr Asp Pro Asn Cys Ser Ser Val Val Glu 
    50                  55                  60                  


Val Ala Ser Asp Glu Glu Glu Pro Thr Ser Ala Gly Pro Cys Thr Pro 
65                  70                  75                  80  


Asn Pro Cys His Asn Gly Gly Thr Cys Glu Ile Ser Glu Ala Tyr Arg 
                85                  90                  95      


Gly Asp Thr Phe Ile Gly Tyr Val Cys Lys Cys Pro Arg Gly Phe Asn 
            100                 105                 110         


Gly Ile His Cys Gln His Asn Ile Asn Glu Cys Glu Val Glu Pro Cys 
        115                 120                 125             


Lys Asn Gly Gly Ile Cys Thr Asp Leu Val Ala Asn Tyr Ser Cys Glu 
    130                 135                 140                 


Cys Pro Gly Glu Phe Met Gly Arg Asn Cys Gln Tyr Lys Cys Ser Gly 
145                 150                 155                 160 


Pro Leu Gly Ile Glu Gly Gly Ile Ile Ser Asn Gln Gln Ile Thr Ala 
                165                 170                 175     


Ser Ser Thr His Arg Ala Leu Phe Gly Leu Gln Lys Trp Tyr Pro Tyr 
            180                 185                 190         


Tyr Ala Arg Leu Asn Lys Lys Gly Leu Ile Asn Ala Trp Thr Ala Ala 
        195                 200                 205             


Glu Asn Asp Arg Trp Pro Trp Ile Gln Ile Asn Leu Gln Arg Lys Met 
    210                 215                 220                 


Arg Val Thr Gly Val Ile Thr Gln Gly Ala Lys Arg Ile Gly Ser Pro 
225                 230                 235                 240 


Glu Tyr Ile Lys Ser Tyr Lys Ile Ala Tyr Ser Asn Asp Gly Lys Thr 
                245                 250                 255     


Trp Ala Met Tyr Lys Val Lys Gly Thr Asn Glu Asp Met Val Phe Arg 
            260                 265                 270         


Gly Asn Ile Asp Asn Asn Thr Pro Tyr Ala Asn Ser Phe Thr Pro Pro 
        275                 280                 285             


Ile Lys Ala Gln Tyr Val Arg Leu Tyr Pro Gln Val Cys Arg Arg His 
    290                 295                 300                 


Cys Thr Leu Arg Met Glu Leu Leu Gly Cys Glu Leu Ser Gly Cys Ser 
305                 310                 315                 320 


Glu Pro Leu Gly Met Lys Ser Gly His Ile Gln Asp Tyr Gln Ile Thr 
                325                 330                 335     


Ala Ser Ser Ile Phe Arg Thr Leu Asn Met Asp Met Phe Thr Trp Glu 
            340                 345                 350         


Pro Arg Lys Ala Arg Leu Asp Lys Gln Gly Lys Val Asn Ala Trp Thr 
        355                 360                 365             


Ser Gly His Asn Asp Gln Ser Gln Trp Leu Gln Val Asp Leu Leu Val 
    370                 375                 380                 


Pro Thr Lys Val Thr Gly Ile Ile Thr Gln Gly Ala Lys Asp Phe Gly 
385                 390                 395                 400 


His Val Gln Phe Val Gly Ser Tyr Lys Leu Ala Tyr Ser Asn Asp Gly 
                405                 410                 415     


Glu His Trp Thr Val Tyr Gln Asp Glu Lys Gln Arg Lys Asp Lys Val 
            420                 425                 430         


Phe Gln Gly Asn Phe Asp Asn Asp Thr His Arg Lys Asn Val Ile Asp 
        435                 440                 445             


Pro Pro Ile Tyr Ala Arg His Ile Arg Ile Leu Pro Trp Ser Trp Tyr 
    450                 455                 460                 


Gly Arg Ile Thr Leu Arg Ser Glu Leu Leu Gly Cys Thr Glu Glu Glu 
465                 470                 475                 480 


<210>  4540
<211>  470
<212>  PRT
<213>  Homo Sapiens

<400>  4540

Met Lys Arg Ser Val Ala Val Trp Leu Leu Val Gly Leu Ser Leu Gly 
1               5                   10                  15      


Val Pro Gln Phe Gly Lys Gly Asp Ile Cys Asp Pro Asn Pro Cys Glu 
            20                  25                  30          


Asn Gly Gly Ile Cys Leu Pro Gly Leu Ala Asp Gly Ser Phe Ser Cys 
        35                  40                  45              


Glu Cys Pro Asp Gly Phe Thr Asp Pro Asn Cys Ser Ser Val Val Glu 
    50                  55                  60                  


Val Gly Pro Cys Thr Pro Asn Pro Cys His Asn Gly Gly Thr Cys Glu 
65                  70                  75                  80  


Ile Ser Glu Ala Tyr Arg Gly Asp Thr Phe Ile Gly Tyr Val Cys Lys 
                85                  90                  95      


Cys Pro Arg Gly Phe Asn Gly Ile His Cys Gln His Asn Ile Asn Glu 
            100                 105                 110         


Cys Glu Val Glu Pro Cys Lys Asn Gly Gly Ile Cys Thr Asp Leu Val 
        115                 120                 125             


Ala Asn Tyr Ser Cys Glu Cys Pro Gly Glu Phe Met Gly Arg Asn Cys 
    130                 135                 140                 


Gln Tyr Lys Cys Ser Gly Pro Leu Gly Ile Glu Gly Gly Ile Ile Ser 
145                 150                 155                 160 


Asn Gln Gln Ile Thr Ala Ser Ser Thr His Arg Ala Leu Phe Gly Leu 
                165                 170                 175     


Gln Lys Trp Tyr Pro Tyr Tyr Ala Arg Leu Asn Lys Lys Gly Leu Ile 
            180                 185                 190         


Asn Ala Trp Thr Ala Ala Glu Asn Asp Arg Trp Pro Trp Ile Gln Ile 
        195                 200                 205             


Asn Leu Gln Arg Lys Met Arg Val Thr Gly Val Ile Thr Gln Gly Ala 
    210                 215                 220                 


Lys Arg Ile Gly Ser Pro Glu Tyr Ile Lys Ser Tyr Lys Ile Ala Tyr 
225                 230                 235                 240 


Ser Asn Asp Gly Lys Thr Trp Ala Met Tyr Lys Val Lys Gly Thr Asn 
                245                 250                 255     


Glu Asp Met Val Phe Arg Gly Asn Ile Asp Asn Asn Thr Pro Tyr Ala 
            260                 265                 270         


Asn Ser Phe Thr Pro Pro Ile Lys Ala Gln Tyr Val Arg Leu Tyr Pro 
        275                 280                 285             


Gln Val Cys Arg Arg His Cys Thr Leu Arg Met Glu Leu Leu Gly Cys 
    290                 295                 300                 


Glu Leu Ser Gly Cys Ser Glu Pro Leu Gly Met Lys Ser Gly His Ile 
305                 310                 315                 320 


Gln Asp Tyr Gln Ile Thr Ala Ser Ser Ile Phe Arg Thr Leu Asn Met 
                325                 330                 335     


Asp Met Phe Thr Trp Glu Pro Arg Lys Ala Arg Leu Asp Lys Gln Gly 
            340                 345                 350         


Lys Val Asn Ala Trp Thr Ser Gly His Asn Asp Gln Ser Gln Trp Leu 
        355                 360                 365             


Gln Val Asp Leu Leu Val Pro Thr Lys Val Thr Gly Ile Ile Thr Gln 
    370                 375                 380                 


Gly Ala Lys Asp Phe Gly His Val Gln Phe Val Gly Ser Tyr Lys Leu 
385                 390                 395                 400 


Ala Tyr Ser Asn Asp Gly Glu His Trp Thr Val Tyr Gln Asp Glu Lys 
                405                 410                 415     


Gln Arg Lys Asp Lys Val Phe Gln Gly Asn Phe Asp Asn Asp Thr His 
            420                 425                 430         


Arg Lys Asn Val Ile Asp Pro Pro Ile Tyr Ala Arg His Ile Arg Ile 
        435                 440                 445             


Leu Pro Trp Ser Trp Tyr Gly Arg Ile Thr Leu Arg Ser Glu Leu Leu 
    450                 455                 460                 


Gly Cys Thr Glu Glu Glu 
465                 470 


<210>  4541
<211>  212
<212>  PRT
<213>  Homo Sapiens

<400>  4541

Met Asp Tyr Leu Leu Met Ile Phe Ser Leu Leu Phe Val Ala Cys Gln 
1               5                   10                  15      


Gly Ala Pro Glu Thr Ala Val Leu Gly Ala Glu Leu Ser Ala Val Gly 
            20                  25                  30          


Glu Asn Gly Gly Glu Lys Pro Thr Pro Ser Pro Pro Trp Arg Leu Arg 
        35                  40                  45              


Arg Ser Lys Arg Cys Ser Cys Ser Ser Leu Met Asp Lys Glu Cys Val 
    50                  55                  60                  


Tyr Phe Cys His Leu Asp Ile Ile Trp Val Asn Thr Pro Glu His Val 
65                  70                  75                  80  


Val Pro Tyr Gly Leu Gly Ser Pro Arg Ser Lys Arg Ala Leu Glu Asn 
                85                  90                  95      


Leu Leu Pro Thr Lys Ala Thr Asp Arg Glu Asn Arg Cys Gln Cys Ala 
            100                 105                 110         


Ser Gln Lys Asp Lys Lys Cys Trp Asn Phe Cys Gln Ala Gly Lys Glu 
        115                 120                 125             


Leu Arg Ala Glu Asp Ile Met Glu Lys Asp Trp Asn Asn His Lys Lys 
    130                 135                 140                 


Gly Lys Asp Cys Ser Lys Leu Gly Lys Lys Cys Ile Tyr Gln Gln Leu 
145                 150                 155                 160 


Val Arg Gly Arg Lys Ile Arg Arg Ser Ser Glu Glu His Leu Arg Gln 
                165                 170                 175     


Thr Arg Ser Glu Thr Met Arg Asn Ser Val Lys Ser Ser Phe His Asp 
            180                 185                 190         


Pro Lys Leu Lys Gly Lys Pro Ser Arg Glu Arg Tyr Val Thr His Asn 
        195                 200                 205             


Arg Ala His Trp 
    210         


<210>  4542
<211>  178
<212>  PRT
<213>  Homo Sapiens

<400>  4542

Met Val Ser Val Pro Thr Thr Trp Cys Ser Val Ala Leu Ala Leu Leu 
1               5                   10                  15      


Val Ala Leu His Glu Gly Lys Gly Gln Ala Ala Ala Thr Leu Glu Gln 
            20                  25                  30          


Pro Ala Ser Ser Ser His Ala Gln Gly Thr His Leu Arg Leu Arg Arg 
        35                  40                  45              


Cys Ser Cys Ser Ser Trp Leu Asp Lys Glu Cys Val Tyr Phe Cys His 
    50                  55                  60                  


Leu Asp Ile Ile Trp Val Asn Thr Pro Glu Gln Thr Ala Pro Tyr Gly 
65                  70                  75                  80  


Leu Gly Asn Pro Pro Arg Arg Arg Arg Arg Ser Leu Pro Arg Arg Cys 
                85                  90                  95      


Gln Cys Ser Ser Ala Arg Asp Pro Ala Cys Ala Thr Phe Cys Leu Arg 
            100                 105                 110         


Arg Pro Trp Thr Glu Ala Gly Ala Val Pro Ser Arg Lys Ser Pro Ala 
        115                 120                 125             


Asp Val Phe Gln Thr Gly Lys Thr Gly Ala Thr Thr Gly Glu Leu Leu 
    130                 135                 140                 


Gln Arg Leu Arg Asp Ile Ser Thr Val Lys Ser Leu Phe Ala Lys Arg 
145                 150                 155                 160 


Gln Gln Glu Ala Met Arg Glu Pro Arg Ser Thr His Ser Arg Trp Arg 
                165                 170                 175     


Lys Arg 
        


<210>  4543
<211>  192
<212>  PRT
<213>  Homo Sapiens

<400>  4543

Met Glu Pro Gly Leu Trp Leu Leu Phe Gly Leu Thr Val Thr Ser Ala 
1               5                   10                  15      


Ala Gly Phe Val Pro Cys Ser Gln Ser Gly Asp Ala Gly Arg Arg Gly 
            20                  25                  30          


Val Ser Gln Ala Pro Thr Ala Ala Arg Ser Glu Gly Asp Cys Glu Glu 
        35                  40                  45              


Thr Val Ala Gly Pro Gly Glu Glu Thr Val Ala Gly Pro Gly Glu Gly 
    50                  55                  60                  


Thr Val Ala Pro Thr Ala Leu Gln Gly Pro Ser Pro Gly Ser Pro Gly 
65                  70                  75                  80  


Gln Glu Gln Ala Ala Glu Gly Ala Pro Glu His His Arg Ser Arg Arg 
                85                  90                  95      


Cys Thr Cys Phe Thr Tyr Lys Asp Lys Glu Cys Val Tyr Tyr Cys His 
            100                 105                 110         


Leu Asp Ile Ile Trp Ile Asn Thr Pro Glu Gln Thr Val Pro Tyr Gly 
        115                 120                 125             


Leu Ser Asn Tyr Arg Gly Ser Phe Arg Gly Lys Arg Ser Ala Gly Pro 
    130                 135                 140                 


Leu Pro Gly Asn Leu Gln Leu Ser His Arg Pro His Leu Arg Cys Ala 
145                 150                 155                 160 


Cys Val Gly Arg Tyr Asp Lys Ala Cys Leu His Phe Cys Thr Gln Thr 
                165                 170                 175     


Leu Asp Val Ser Arg Leu Lys Ser Arg Thr Asn Lys Ala Ser Arg Leu 
            180                 185                 190         


<210>  4544
<211>  224
<212>  PRT
<213>  Homo Sapiens

<400>  4544

Met Glu Pro Gly Leu Trp Leu Leu Phe Gly Leu Thr Val Thr Ser Ala 
1               5                   10                  15      


Ala Gly Phe Val Pro Cys Ser Gln Ser Gly Asp Ala Gly Arg Arg Gly 
            20                  25                  30          


Val Ser Gln Ala Pro Thr Ala Ala Arg Ser Glu Gly Asp Cys Glu Glu 
        35                  40                  45              


Thr Val Ala Gly Pro Gly Glu Glu Thr Val Ala Gly Pro Gly Glu Gly 
    50                  55                  60                  


Thr Val Ala Pro Thr Ala Leu Gln Gly Pro Ser Pro Gly Ser Pro Gly 
65                  70                  75                  80  


Gln Glu Gln Ala Ala Glu Gly Ala Pro Glu His His Arg Ser Arg Arg 
                85                  90                  95      


Cys Thr Cys Phe Thr Tyr Lys Asp Lys Glu Cys Val Tyr Tyr Cys His 
            100                 105                 110         


Leu Asp Ile Ile Trp Ile Asn Thr Pro Glu Gln Thr Val Pro Tyr Gly 
        115                 120                 125             


Leu Ser Asn Tyr Arg Gly Ser Phe Arg Gly Lys Arg Ser Ala Gly Pro 
    130                 135                 140                 


Leu Pro Gly Asn Leu Gln Leu Ser His Arg Pro His Leu Arg Cys Ala 
145                 150                 155                 160 


Cys Val Gly Arg Tyr Asp Lys Ala Cys Leu His Phe Cys Thr Gln Thr 
                165                 170                 175     


Leu Asp Val Ser Arg Gln Val Glu Val Lys Asp Gln Gln Ser Lys Gln 
            180                 185                 190         


Ala Leu Asp Leu His His Pro Lys Leu Met Pro Gly Ser Gly Leu Ala 
        195                 200                 205             


Leu Ala Pro Ser Thr Cys Pro Arg Cys Leu Phe Gln Glu Gly Ala Pro 
    210                 215                 220                 


<210>  4545
<211>  238
<212>  PRT
<213>  Homo Sapiens

<400>  4545

Met Glu Pro Gly Leu Trp Leu Leu Phe Gly Leu Thr Val Thr Ser Ala 
1               5                   10                  15      


Ala Gly Phe Val Pro Cys Ser Gln Ser Gly Asp Ala Gly Arg Arg Gly 
            20                  25                  30          


Val Ser Gln Ala Pro Thr Ala Ala Arg Ser Glu Gly Asp Cys Glu Glu 
        35                  40                  45              


Thr Val Ala Gly Pro Gly Glu Glu Thr Val Ala Gly Pro Gly Glu Gly 
    50                  55                  60                  


Thr Val Ala Pro Thr Ala Leu Gln Gly Pro Ser Pro Gly Ser Pro Gly 
65                  70                  75                  80  


Gln Glu Gln Ala Ala Glu Gly Ala Pro Glu His His Arg Ser Arg Arg 
                85                  90                  95      


Cys Thr Cys Phe Thr Tyr Lys Asp Lys Glu Cys Val Tyr Tyr Cys His 
            100                 105                 110         


Leu Asp Ile Ile Trp Ile Asn Thr Pro Glu Gln Thr Val Pro Tyr Gly 
        115                 120                 125             


Leu Ser Asn Tyr Arg Gly Ser Phe Arg Gly Lys Arg Ser Ala Gly Pro 
    130                 135                 140                 


Leu Pro Gly Asn Leu Gln Leu Ser His Arg Pro His Leu Arg Cys Ala 
145                 150                 155                 160 


Cys Val Gly Arg Tyr Asp Lys Ala Cys Leu His Phe Cys Thr Gln Thr 
                165                 170                 175     


Leu Asp Val Ser Ser Asn Ser Arg Thr Ala Glu Lys Thr Asp Lys Glu 
            180                 185                 190         


Glu Glu Gly Lys Val Glu Val Lys Asp Gln Gln Ser Lys Gln Ala Leu 
        195                 200                 205             


Asp Leu His His Pro Lys Leu Met Pro Gly Ser Gly Leu Ala Leu Ala 
    210                 215                 220                 


Pro Ser Thr Cys Pro Arg Cys Leu Phe Gln Glu Gly Ala Pro 
225                 230                 235             


<210>  4546
<211>  238
<212>  PRT
<213>  Homo Sapiens

<400>  4546

Met Glu Pro Gly Leu Trp Leu Leu Phe Gly Leu Thr Val Thr Ser Ala 
1               5                   10                  15      


Ala Gly Phe Val Pro Cys Ser Gln Ser Gly Asp Ala Gly Arg Arg Gly 
            20                  25                  30          


Val Ser Gln Ala Pro Thr Ala Ala Arg Ser Glu Gly Asp Cys Glu Glu 
        35                  40                  45              


Thr Val Ala Gly Pro Gly Glu Glu Thr Val Ala Gly Pro Gly Glu Gly 
    50                  55                  60                  


Thr Val Ala Pro Thr Ala Leu Gln Gly Pro Ser Pro Gly Ser Pro Gly 
65                  70                  75                  80  


Gln Glu Gln Ala Ala Glu Gly Ala Pro Glu His His Arg Ser Arg Arg 
                85                  90                  95      


Cys Thr Cys Phe Thr Tyr Lys Asp Lys Glu Cys Val Tyr Tyr Cys His 
            100                 105                 110         


Leu Asp Ile Ile Trp Ile Asn Thr Pro Glu Gln Thr Val Pro Tyr Gly 
        115                 120                 125             


Leu Ser Asn Tyr Arg Gly Ser Phe Arg Gly Lys Arg Ser Ala Gly Pro 
    130                 135                 140                 


Leu Pro Gly Asn Leu Gln Leu Ser His Arg Pro His Leu Arg Cys Ala 
145                 150                 155                 160 


Cys Val Gly Arg Tyr Asp Lys Ala Cys Leu His Phe Cys Thr Gln Thr 
                165                 170                 175     


Leu Asp Val Ser Ser Asn Ser Arg Thr Ala Glu Lys Thr Asp Lys Glu 
            180                 185                 190         


Glu Glu Gly Lys Val Glu Val Lys Asp Gln Gln Ser Lys Gln Ala Leu 
        195                 200                 205             


Asp Leu His His Pro Lys Leu Met Pro Gly Ser Gly Leu Ala Leu Ala 
    210                 215                 220                 


Pro Ser Thr Cys Pro Arg Cys Leu Phe Gln Glu Gly Ala Pro 
225                 230                 235             


<210>  4547
<211>  219
<212>  PRT
<213>  Homo Sapiens

<400>  4547

Met Glu Pro Gly Leu Trp Leu Leu Phe Gly Leu Thr Val Thr Ser Ala 
1               5                   10                  15      


Ala Gly Phe Val Pro Cys Ser Gln Ser Gly Asp Ala Gly Arg Arg Gly 
            20                  25                  30          


Val Ser Gln Ala Pro Thr Ala Ala Arg Ser Glu Gly Asp Cys Glu Glu 
        35                  40                  45              


Thr Val Ala Gly Pro Gly Glu Glu Thr Val Ala Gly Pro Gly Glu Gly 
    50                  55                  60                  


Thr Val Ala Pro Thr Ala Leu Gln Gly Pro Ser Pro Gly Ser Pro Gly 
65                  70                  75                  80  


Gln Glu Gln Ala Ala Glu Gly Ala Pro Glu His His Arg Ser Arg Arg 
                85                  90                  95      


Cys Thr Cys Phe Thr Tyr Lys Asp Lys Glu Cys Val Tyr Tyr Cys His 
            100                 105                 110         


Leu Asp Ile Ile Trp Ile Asn Thr Pro Glu Gln Thr Val Pro Tyr Gly 
        115                 120                 125             


Leu Ser Asn Tyr Arg Gly Ser Phe Arg Gly Lys Arg Ser Ala Gly Pro 
    130                 135                 140                 


Leu Pro Gly Asn Leu Gln Leu Ser His Arg Pro His Leu Arg Cys Ala 
145                 150                 155                 160 


Cys Val Gly Arg Tyr Asp Lys Ala Cys Leu His Phe Cys Thr Gln Thr 
                165                 170                 175     


Leu Asp Val Ser Ser Asn Ser Arg Thr Ala Glu Lys Thr Asp Lys Glu 
            180                 185                 190         


Glu Glu Gly Lys Val Arg Gly Ala Asn Arg Gly Leu Cys Gln Arg Arg 
        195                 200                 205             


Leu Lys Ser Arg Thr Asn Lys Ala Ser Arg Leu 
    210                 215                 


<210>  4548
<211>  198
<212>  PRT
<213>  Homo Sapiens

<400>  4548

Met Glu Pro Gly Leu Trp Leu Leu Phe Gly Leu Thr Val Thr Ser Ala 
1               5                   10                  15      


Ala Gly Phe Val Pro Cys Ser Gln Ser Gly Asp Ala Gly Arg Arg Gly 
            20                  25                  30          


Val Ser Gln Ala Pro Thr Ala Ala Arg Ser Glu Gly Asp Cys Glu Glu 
        35                  40                  45              


Thr Val Ala Gly Pro Gly Glu Glu Thr Val Ala Gly Pro Gly Glu Gly 
    50                  55                  60                  


Thr Val Ala Pro Thr Ala Leu Gln Gly Pro Ser Pro Gly Ser Pro Gly 
65                  70                  75                  80  


Gln Glu Gln Ala Ala Glu Gly Ala Pro Glu His His Arg Ser Arg Arg 
                85                  90                  95      


Cys Thr Cys Phe Thr Tyr Lys Asp Lys Glu Cys Val Tyr Tyr Cys His 
            100                 105                 110         


Leu Asp Ile Ile Trp Ile Asn Thr Pro Glu Gln Thr Val Pro Tyr Gly 
        115                 120                 125             


Leu Ser Asn Tyr Arg Gly Ser Phe Arg Gly Lys Arg Ser Ala Gly Pro 
    130                 135                 140                 


Leu Pro Gly Asn Leu Gln Leu Ser His Arg Pro His Leu Arg Cys Ala 
145                 150                 155                 160 


Cys Val Gly Arg Tyr Asp Lys Ala Cys Leu His Phe Cys Thr Gln Thr 
                165                 170                 175     


Leu Asp Val Ser Ser Asn Ser Arg Thr Ala Glu Lys Thr Asp Lys Glu 
            180                 185                 190         


Glu Glu Gly Lys Val Thr 
        195             


<210>  4549
<211>  162
<212>  PRT
<213>  Homo Sapiens

<400>  4549

Lys Leu Val Pro Phe Ile Gln Lys Ala Ser Val Gly Ile Thr Val Leu 
1               5                   10                  15      


Ser Leu Cys Ala Leu Ser Ile Asp Arg Tyr Arg Ala Val Ala Ser Trp 
            20                  25                  30          


Ser Arg Ile Lys Gly Ile Gly Val Pro Lys Trp Thr Ala Val Glu Ile 
        35                  40                  45              


Val Leu Ile Trp Val Val Ser Val Val Leu Ala Val Pro Glu Ala Ile 
    50                  55                  60                  


Gly Phe Asp Ile Ile Thr Met Asp Tyr Lys Gly Ser Tyr Leu Arg Ile 
65                  70                  75                  80  


Cys Leu Leu His Pro Val Gln Lys Thr Ala Phe Met Gln Phe Tyr Lys 
                85                  90                  95      


Thr Ala Lys Asp Trp Trp Leu Phe Ser Phe Tyr Phe Cys Leu Pro Leu 
            100                 105                 110         


Ala Ile Thr Ala Phe Phe Tyr Thr Leu Met Thr Cys Glu Met Leu Arg 
        115                 120                 125             


Lys Lys Ser Gly Met Gln Ile Ala Leu Asn Asp His Leu Lys Gln Leu 
    130                 135                 140                 


Ser Val Gly Ile Gly Leu Tyr Trp Tyr Gln His Gly Phe Thr Glu Phe 
145                 150                 155                 160 


Leu His 
        


<210>  4550
<211>  532
<212>  PRT
<213>  Homo Sapiens

<400>  4550

Met Asn Lys Ser Thr Cys Leu Met Ala Ala Glu Thr Pro Ser Lys Arg 
1               5                   10                  15      


Trp Arg Leu His Cys Leu Ala Phe Ser Gln Arg Phe Val Arg Ala Gly 
            20                  25                  30          


Pro Ala Cys Ser Ser Arg Glu Ala Cys Ser Ser Pro Arg Ala Gly Trp 
        35                  40                  45              


Asn Pro Ala Gly Phe Arg Leu Pro Gly Arg Trp Ser Pro Phe Val Ala 
    50                  55                  60                  


Leu His Leu Val Cys Gln Ile Arg Glu Ala Leu Lys Leu Arg Ser Gly 
65                  70                  75                  80  


His Arg Thr Pro Ser Gly Ala Gly Ser Ser Met Gln Pro Pro Pro Ser 
                85                  90                  95      


Leu Cys Gly Arg Ala Leu Val Ala Leu Val Leu Ala Cys Gly Leu Ser 
            100                 105                 110         


Arg Ile Trp Gly Glu Glu Arg Gly Phe Pro Pro Asp Arg Ala Thr Pro 
        115                 120                 125             


Leu Leu Gln Thr Ala Glu Ile Met Thr Pro Pro Thr Lys Thr Leu Trp 
    130                 135                 140                 


Pro Lys Gly Ser Asn Ala Ser Leu Ala Arg Ser Leu Ala Pro Ala Glu 
145                 150                 155                 160 


Val Pro Lys Gly Asp Arg Thr Ala Gly Ser Pro Pro Arg Thr Ile Ser 
                165                 170                 175     


Pro Pro Pro Cys Gln Gly Pro Ile Glu Ile Lys Glu Thr Phe Lys Tyr 
            180                 185                 190         


Ile Asn Thr Val Val Ser Cys Leu Val Phe Val Leu Gly Ile Ile Gly 
        195                 200                 205             


Asn Ser Thr Leu Leu Arg Ile Ile Tyr Lys Asn Lys Cys Met Arg Asn 
    210                 215                 220                 


Gly Pro Asn Ile Leu Ile Ala Ser Leu Ala Leu Gly Asp Leu Leu His 
225                 230                 235                 240 


Ile Val Ile Asp Ile Pro Ile Asn Val Tyr Lys Leu Leu Ala Glu Asp 
                245                 250                 255     


Trp Pro Phe Gly Ala Glu Met Cys Lys Leu Val Pro Phe Ile Gln Lys 
            260                 265                 270         


Ala Ser Val Gly Ile Thr Val Leu Ser Leu Cys Ala Leu Ser Ile Asp 
        275                 280                 285             


Arg Tyr Arg Ala Val Ala Ser Trp Ser Arg Ile Lys Gly Ile Gly Val 
    290                 295                 300                 


Pro Lys Trp Thr Ala Val Glu Ile Val Leu Ile Trp Val Val Ser Val 
305                 310                 315                 320 


Val Leu Ala Val Pro Glu Ala Ile Gly Phe Asp Ile Ile Thr Met Asp 
                325                 330                 335     


Tyr Lys Gly Ser Tyr Leu Arg Ile Cys Leu Leu His Pro Val Gln Lys 
            340                 345                 350         


Thr Ala Phe Met Gln Phe Tyr Lys Thr Ala Lys Asp Trp Trp Leu Phe 
        355                 360                 365             


Ser Phe Tyr Phe Cys Leu Pro Leu Ala Ile Thr Ala Phe Phe Tyr Thr 
    370                 375                 380                 


Leu Met Thr Cys Glu Met Leu Arg Lys Lys Ser Gly Met Gln Ile Ala 
385                 390                 395                 400 


Leu Asn Asp His Leu Lys Gln Arg Arg Glu Val Ala Lys Thr Val Phe 
                405                 410                 415     


Cys Leu Val Leu Val Phe Ala Leu Cys Trp Leu Pro Leu His Leu Ser 
            420                 425                 430         


Arg Ile Leu Lys Leu Thr Leu Tyr Asn Gln Asn Asp Pro Asn Arg Cys 
        435                 440                 445             


Glu Leu Leu Ser Phe Leu Leu Val Leu Asp Tyr Ile Gly Ile Asn Met 
    450                 455                 460                 


Ala Ser Leu Asn Ser Cys Ile Asn Pro Ile Ala Leu Tyr Leu Val Ser 
465                 470                 475                 480 


Lys Arg Phe Lys Asn Cys Phe Lys Ser Cys Leu Cys Cys Trp Cys Gln 
                485                 490                 495     


Ser Phe Glu Glu Lys Gln Ser Leu Glu Glu Lys Gln Ser Cys Leu Lys 
            500                 505                 510         


Phe Lys Ala Asn Asp His Gly Tyr Asp Asn Phe Arg Ser Ser Asn Lys 
        515                 520                 525             


Tyr Ser Ser Ser 
    530         


<210>  4551
<211>  442
<212>  PRT
<213>  Homo Sapiens

<400>  4551

Met Gln Pro Pro Pro Ser Leu Cys Gly Arg Ala Leu Val Ala Leu Val 
1               5                   10                  15      


Leu Ala Cys Gly Leu Ser Arg Ile Trp Gly Glu Glu Arg Gly Phe Pro 
            20                  25                  30          


Pro Asp Arg Ala Thr Pro Leu Leu Gln Thr Ala Glu Ile Met Thr Pro 
        35                  40                  45              


Pro Thr Lys Thr Leu Trp Pro Lys Gly Ser Asn Ala Ser Leu Ala Arg 
    50                  55                  60                  


Ser Leu Ala Pro Ala Glu Val Pro Lys Gly Asp Arg Thr Ala Gly Ser 
65                  70                  75                  80  


Pro Pro Arg Thr Ile Ser Pro Pro Pro Cys Gln Gly Pro Ile Glu Ile 
                85                  90                  95      


Lys Glu Thr Phe Lys Tyr Ile Asn Thr Val Val Ser Cys Leu Val Phe 
            100                 105                 110         


Val Leu Gly Ile Ile Gly Asn Ser Thr Leu Leu Arg Ile Ile Tyr Lys 
        115                 120                 125             


Asn Lys Cys Met Arg Asn Gly Pro Asn Ile Leu Ile Ala Ser Leu Ala 
    130                 135                 140                 


Leu Gly Asp Leu Leu His Ile Val Ile Asp Ile Pro Ile Asn Val Tyr 
145                 150                 155                 160 


Lys Leu Leu Ala Glu Asp Trp Pro Phe Gly Ala Glu Met Cys Lys Leu 
                165                 170                 175     


Val Pro Phe Ile Gln Lys Ala Ser Val Gly Ile Thr Val Leu Ser Leu 
            180                 185                 190         


Cys Ala Leu Ser Ile Asp Arg Tyr Arg Ala Val Ala Ser Trp Ser Arg 
        195                 200                 205             


Ile Lys Gly Ile Gly Val Pro Lys Trp Thr Ala Val Glu Ile Val Leu 
    210                 215                 220                 


Ile Trp Val Val Ser Val Val Leu Ala Val Pro Glu Ala Ile Gly Phe 
225                 230                 235                 240 


Asp Ile Ile Thr Met Asp Tyr Lys Gly Ser Tyr Leu Arg Ile Cys Leu 
                245                 250                 255     


Leu His Pro Val Gln Lys Thr Ala Phe Met Gln Phe Tyr Lys Thr Ala 
            260                 265                 270         


Lys Asp Trp Trp Leu Phe Ser Phe Tyr Phe Cys Leu Pro Leu Ala Ile 
        275                 280                 285             


Thr Ala Phe Phe Tyr Thr Leu Met Thr Cys Glu Met Leu Arg Lys Lys 
    290                 295                 300                 


Ser Gly Met Gln Ile Ala Leu Asn Asp His Leu Lys Gln Arg Arg Glu 
305                 310                 315                 320 


Val Ala Lys Thr Val Phe Cys Leu Val Leu Val Phe Ala Leu Cys Trp 
                325                 330                 335     


Leu Pro Leu His Leu Ser Arg Ile Leu Lys Leu Thr Leu Tyr Asn Gln 
            340                 345                 350         


Asn Asp Pro Asn Arg Cys Glu Leu Leu Ser Phe Leu Leu Val Leu Asp 
        355                 360                 365             


Tyr Ile Gly Ile Asn Met Ala Ser Leu Asn Ser Cys Ile Asn Pro Ile 
    370                 375                 380                 


Ala Leu Tyr Leu Val Ser Lys Arg Phe Lys Asn Cys Phe Lys Ser Cys 
385                 390                 395                 400 


Leu Cys Cys Trp Cys Gln Ser Phe Glu Glu Lys Gln Ser Leu Glu Glu 
                405                 410                 415     


Lys Gln Ser Cys Leu Lys Phe Lys Ala Asn Asp His Gly Tyr Asp Asn 
            420                 425                 430         


Phe Arg Ser Ser Asn Lys Tyr Ser Ser Ser 
        435                 440         


<210>  4552
<211>  409
<212>  PRT
<213>  Homo Sapiens

<400>  4552

Met Gln Pro Pro Pro Ser Leu Cys Gly Arg Ala Leu Val Ala Leu Val 
1               5                   10                  15      


Leu Ala Cys Gly Leu Ser Arg Ile Trp Gly Glu Glu Arg Gly Phe Pro 
            20                  25                  30          


Pro Asp Arg Ala Thr Pro Leu Leu Gln Thr Ala Glu Ile Met Thr Pro 
        35                  40                  45              


Pro Thr Lys Thr Leu Trp Pro Lys Gly Ser Asn Ala Ser Leu Ala Arg 
    50                  55                  60                  


Ser Leu Ala Pro Ala Glu Val Pro Lys Gly Asp Arg Thr Ala Gly Ser 
65                  70                  75                  80  


Pro Pro Arg Thr Ile Ser Pro Pro Pro Cys Gln Gly Pro Ile Glu Ile 
                85                  90                  95      


Lys Glu Thr Phe Lys Tyr Ile Asn Thr Val Val Ser Cys Leu Val Phe 
            100                 105                 110         


Val Leu Gly Ile Ile Gly Asn Ser Thr Leu Leu Arg Ile Ile Tyr Lys 
        115                 120                 125             


Asn Lys Cys Met Arg Asn Gly Pro Asn Ile Leu Ile Ala Ser Leu Ala 
    130                 135                 140                 


Leu Gly Asp Leu Leu His Ile Val Ile Asp Ile Pro Ile Asn Val Tyr 
145                 150                 155                 160 


Lys Leu Leu Ala Glu Asp Trp Pro Phe Gly Ala Glu Met Cys Lys Leu 
                165                 170                 175     


Val Pro Phe Ile Gln Lys Ala Ser Val Gly Ile Thr Val Leu Ser Leu 
            180                 185                 190         


Cys Ala Leu Ser Ile Asp Arg Tyr Arg Ala Val Ala Ser Trp Ser Arg 
        195                 200                 205             


Ile Lys Gly Ile Gly Val Pro Lys Trp Thr Ala Val Glu Ile Val Leu 
    210                 215                 220                 


Ile Trp Val Val Ser Val Val Leu Ala Val Pro Glu Ala Ile Gly Phe 
225                 230                 235                 240 


Asp Ile Ile Thr Met Asp Tyr Lys Gly Ser Tyr Leu Arg Ile Cys Leu 
                245                 250                 255     


Leu His Pro Val Gln Lys Thr Ala Phe Met Gln Phe Tyr Lys Thr Ala 
            260                 265                 270         


Lys Asp Trp Trp Leu Phe Ser Phe Tyr Phe Cys Leu Pro Leu Ala Ile 
        275                 280                 285             


Thr Ala Phe Phe Tyr Thr Leu Met Thr Cys Glu Met Leu Arg Lys Lys 
    290                 295                 300                 


Ser Gly Met Gln Ile Ala Leu Asn Asp His Leu Lys Gln Arg Arg Glu 
305                 310                 315                 320 


Val Ala Lys Thr Val Phe Cys Leu Val Leu Val Phe Ala Leu Cys Trp 
                325                 330                 335     


Leu Pro Leu His Leu Ser Arg Ile Leu Lys Leu Thr Leu Tyr Asn Gln 
            340                 345                 350         


Asn Asp Pro Asn Arg Cys Glu Leu Leu Ser Phe Leu Leu Val Leu Asp 
        355                 360                 365             


Tyr Ile Gly Ile Asn Met Ala Ser Leu Asn Ser Cys Ile Asn Pro Ile 
    370                 375                 380                 


Ala Leu Tyr Leu Val Ser Lys Arg Phe Lys Asn Cys Phe Lys Val Arg 
385                 390                 395                 400 


Asp Tyr Pro Lys Ile Lys Ser Ser Leu 
                405                 


<210>  4553
<211>  442
<212>  PRT
<213>  Homo Sapiens

<400>  4553

Met Gln Pro Pro Pro Ser Leu Cys Gly Arg Ala Leu Val Ala Leu Val 
1               5                   10                  15      


Leu Ala Cys Gly Leu Ser Arg Ile Trp Gly Glu Glu Arg Gly Phe Pro 
            20                  25                  30          


Pro Asp Arg Ala Thr Pro Leu Leu Gln Thr Ala Glu Ile Met Thr Pro 
        35                  40                  45              


Pro Thr Lys Thr Leu Trp Pro Lys Gly Ser Asn Ala Ser Leu Ala Arg 
    50                  55                  60                  


Ser Leu Ala Pro Ala Glu Val Pro Lys Gly Asp Arg Thr Ala Gly Ser 
65                  70                  75                  80  


Pro Pro Arg Thr Ile Ser Pro Pro Pro Cys Gln Gly Pro Ile Glu Ile 
                85                  90                  95      


Lys Glu Thr Phe Lys Tyr Ile Asn Thr Val Val Ser Cys Leu Val Phe 
            100                 105                 110         


Val Leu Gly Ile Ile Gly Asn Ser Thr Leu Leu Arg Ile Ile Tyr Lys 
        115                 120                 125             


Asn Lys Cys Met Arg Asn Gly Pro Asn Ile Leu Ile Ala Ser Leu Ala 
    130                 135                 140                 


Leu Gly Asp Leu Leu His Ile Val Ile Asp Ile Pro Ile Asn Val Tyr 
145                 150                 155                 160 


Lys Leu Leu Ala Glu Asp Trp Pro Phe Gly Ala Glu Met Cys Lys Leu 
                165                 170                 175     


Val Pro Phe Ile Gln Lys Ala Ser Val Gly Ile Thr Val Leu Ser Leu 
            180                 185                 190         


Cys Ala Leu Ser Ile Asp Arg Tyr Arg Ala Val Ala Ser Trp Ser Arg 
        195                 200                 205             


Ile Lys Gly Ile Gly Val Pro Lys Trp Thr Ala Val Glu Ile Val Leu 
    210                 215                 220                 


Ile Trp Val Val Ser Val Val Leu Ala Val Pro Glu Ala Ile Gly Phe 
225                 230                 235                 240 


Asp Ile Ile Thr Met Asp Tyr Lys Gly Ser Tyr Leu Arg Ile Cys Leu 
                245                 250                 255     


Leu His Pro Val Gln Lys Thr Ala Phe Met Gln Phe Tyr Lys Thr Ala 
            260                 265                 270         


Lys Asp Trp Trp Leu Phe Ser Phe Tyr Phe Cys Leu Pro Leu Ala Ile 
        275                 280                 285             


Thr Ala Phe Phe Tyr Thr Leu Met Thr Cys Glu Met Leu Arg Lys Lys 
    290                 295                 300                 


Ser Gly Met Gln Ile Ala Leu Asn Asp His Leu Lys Gln Arg Arg Glu 
305                 310                 315                 320 


Val Ala Lys Thr Val Phe Cys Leu Val Leu Val Phe Ala Leu Cys Trp 
                325                 330                 335     


Leu Pro Leu His Leu Ser Arg Ile Leu Lys Leu Thr Leu Tyr Asn Gln 
            340                 345                 350         


Asn Asp Pro Asn Arg Cys Glu Leu Leu Ser Phe Leu Leu Val Leu Asp 
        355                 360                 365             


Tyr Ile Gly Ile Asn Met Ala Ser Leu Asn Ser Cys Ile Asn Pro Ile 
    370                 375                 380                 


Ala Leu Tyr Leu Val Ser Lys Arg Phe Lys Asn Cys Phe Lys Ser Cys 
385                 390                 395                 400 


Leu Cys Cys Trp Cys Gln Ser Phe Glu Glu Lys Gln Ser Leu Glu Glu 
                405                 410                 415     


Lys Gln Ser Cys Leu Lys Phe Lys Ala Asn Asp His Gly Tyr Asp Asn 
            420                 425                 430         


Phe Arg Ser Ser Asn Lys Tyr Ser Ser Ser 
        435                 440         


<210>  4554
<211>  436
<212>  PRT
<213>  Homo Sapiens

<400>  4554

Met Gln Pro Pro Pro Ser Leu Cys Gly Arg Ala Leu Val Ala Leu Val 
1               5                   10                  15      


Leu Ala Cys Gly Leu Ser Arg Ile Trp Gly Glu Glu Arg Gly Phe Pro 
            20                  25                  30          


Pro Asp Arg Ala Thr Pro Leu Leu Gln Thr Ala Glu Ile Met Thr Pro 
        35                  40                  45              


Pro Thr Lys Thr Leu Trp Pro Lys Gly Ser Asn Ala Ser Leu Ala Arg 
    50                  55                  60                  


Ser Leu Ala Pro Ala Glu Val Pro Lys Gly Asp Arg Thr Ala Gly Ser 
65                  70                  75                  80  


Pro Pro Arg Thr Ile Ser Pro Pro Pro Cys Gln Gly Pro Ile Glu Ile 
                85                  90                  95      


Lys Glu Thr Phe Lys Tyr Ile Asn Thr Val Val Ser Cys Leu Val Phe 
            100                 105                 110         


Val Leu Gly Ile Ile Gly Asn Ser Thr Leu Leu Arg Ile Ile Tyr Lys 
        115                 120                 125             


Asn Lys Cys Met Arg Asn Gly Pro Asn Ile Leu Ile Ala Ser Leu Ala 
    130                 135                 140                 


Leu Gly Asp Leu Leu His Ile Val Ile Asp Ile Pro Ile Asn Val Tyr 
145                 150                 155                 160 


Lys Leu Leu Ala Glu Asp Trp Pro Phe Gly Ala Glu Met Cys Lys Leu 
                165                 170                 175     


Val Pro Phe Ile Gln Lys Ala Ser Val Gly Ile Thr Val Leu Ser Leu 
            180                 185                 190         


Cys Ala Leu Ser Ile Asp Arg Tyr Arg Ala Val Ala Ser Trp Ser Arg 
        195                 200                 205             


Ile Lys Gly Ile Gly Val Pro Lys Trp Thr Ala Val Glu Ile Val Leu 
    210                 215                 220                 


Ile Trp Val Val Ser Val Val Leu Ala Val Pro Glu Ala Ile Gly Phe 
225                 230                 235                 240 


Asp Ile Ile Thr Met Asp Tyr Lys Gly Ser Tyr Leu Arg Ile Cys Leu 
                245                 250                 255     


Leu His Pro Val Gln Lys Thr Ala Phe Met Gln Phe Tyr Lys Thr Ala 
            260                 265                 270         


Lys Asp Trp Trp Leu Phe Ser Phe Tyr Phe Cys Leu Pro Leu Ala Ile 
        275                 280                 285             


Thr Ala Phe Phe Tyr Thr Leu Met Thr Cys Glu Met Leu Arg Lys Lys 
    290                 295                 300                 


Ser Gly Met Gln Ile Ala Leu Asn Asp His Leu Lys Gln Arg Arg Glu 
305                 310                 315                 320 


Val Ala Lys Thr Val Phe Cys Leu Val Leu Val Phe Ala Leu Cys Trp 
                325                 330                 335     


Leu Pro Leu His Leu Ser Arg Ile Leu Lys Leu Thr Leu Tyr Asn Gln 
            340                 345                 350         


Asn Asp Pro Asn Arg Cys Glu Leu Leu Ser Phe Leu Leu Val Leu Asp 
        355                 360                 365             


Tyr Ile Gly Ile Asn Met Ala Ser Leu Asn Ser Cys Ile Asn Pro Ile 
    370                 375                 380                 


Ala Leu Tyr Leu Val Ser Lys Arg Phe Lys Asn Cys Phe Lys Ala Gly 
385                 390                 395                 400 


Pro His Val Gly Asn Lys Leu Val Met Leu Phe Ser Val Asn Ile Glu 
                405                 410                 415     


Cys Asp Gly Thr Val Asn Gln Asn Pro Thr Met Trp Pro Glu Arg Lys 
            420                 425                 430         


Ser Asn Asn Asn 
        435     


<210>  4555
<211>  442
<212>  PRT
<213>  Homo Sapiens

<400>  4555

Met Gln Pro Pro Pro Ser Leu Cys Gly Arg Ala Leu Val Ala Leu Val 
1               5                   10                  15      


Leu Ala Cys Gly Leu Ser Arg Ile Trp Gly Glu Glu Arg Gly Phe Pro 
            20                  25                  30          


Pro Asp Arg Ala Thr Pro Leu Leu Gln Thr Ala Glu Ile Met Thr Pro 
        35                  40                  45              


Pro Thr Lys Thr Leu Trp Pro Lys Gly Ser Asn Ala Ser Leu Ala Arg 
    50                  55                  60                  


Ser Leu Ala Pro Ala Glu Val Pro Lys Gly Asp Arg Thr Ala Gly Ser 
65                  70                  75                  80  


Pro Pro Arg Thr Ile Ser Pro Pro Pro Cys Gln Gly Pro Ile Glu Ile 
                85                  90                  95      


Lys Glu Thr Phe Lys Tyr Ile Asn Thr Val Val Ser Cys Leu Val Phe 
            100                 105                 110         


Val Leu Gly Ile Ile Gly Asn Ser Thr Leu Leu Arg Ile Ile Tyr Lys 
        115                 120                 125             


Asn Lys Cys Met Arg Asn Gly Pro Asn Ile Leu Ile Ala Ser Leu Ala 
    130                 135                 140                 


Leu Gly Asp Leu Leu His Ile Val Ile Asp Ile Pro Ile Asn Val Tyr 
145                 150                 155                 160 


Lys Leu Leu Ala Glu Asp Trp Pro Phe Gly Ala Glu Met Cys Lys Leu 
                165                 170                 175     


Val Pro Phe Ile Gln Lys Ala Ser Val Gly Ile Thr Val Leu Ser Leu 
            180                 185                 190         


Cys Ala Leu Ser Ile Asp Arg Tyr Arg Ala Val Ala Ser Trp Ser Arg 
        195                 200                 205             


Ile Lys Gly Ile Gly Val Pro Lys Trp Thr Ala Val Glu Ile Val Leu 
    210                 215                 220                 


Ile Trp Val Val Ser Val Val Leu Ala Val Pro Glu Ala Ile Gly Phe 
225                 230                 235                 240 


Asp Ile Ile Thr Met Asp Tyr Lys Gly Ser Tyr Leu Arg Ile Cys Leu 
                245                 250                 255     


Leu His Pro Val Gln Lys Thr Ala Phe Met Gln Phe Tyr Lys Thr Ala 
            260                 265                 270         


Lys Asp Trp Trp Leu Phe Ser Phe Tyr Phe Cys Leu Pro Leu Ala Ile 
        275                 280                 285             


Thr Ala Phe Phe Tyr Thr Leu Met Thr Cys Glu Met Leu Arg Lys Lys 
    290                 295                 300                 


Ser Gly Met Gln Ile Ala Leu Asn Asp His Leu Lys Gln Arg Arg Glu 
305                 310                 315                 320 


Val Ala Lys Thr Val Phe Cys Leu Val Leu Val Phe Ala Leu Cys Trp 
                325                 330                 335     


Leu Pro Leu His Leu Ser Arg Ile Leu Lys Leu Thr Leu Tyr Asn Gln 
            340                 345                 350         


Asn Asp Pro Asn Arg Cys Glu Leu Leu Ser Phe Leu Leu Val Leu Asp 
        355                 360                 365             


Tyr Ile Gly Ile Asn Met Ala Ser Leu Asn Ser Cys Ile Asn Pro Ile 
    370                 375                 380                 


Ala Leu Tyr Leu Val Ser Lys Arg Phe Lys Asn Cys Phe Lys Ser Cys 
385                 390                 395                 400 


Leu Cys Cys Trp Cys Gln Ser Phe Glu Glu Lys Gln Ser Leu Glu Glu 
                405                 410                 415     


Lys Gln Ser Cys Leu Lys Phe Lys Ala Asn Asp His Gly Tyr Asp Asn 
            420                 425                 430         


Phe Arg Ser Ser Asn Lys Tyr Ser Ser Ser 
        435                 440         


<210>  4556
<211>  442
<212>  PRT
<213>  Homo Sapiens

<400>  4556

Met Gln Pro Pro Pro Ser Leu Cys Gly Arg Ala Leu Val Ala Leu Val 
1               5                   10                  15      


Leu Ala Cys Gly Leu Ser Arg Ile Trp Gly Glu Glu Arg Gly Phe Pro 
            20                  25                  30          


Pro Asp Arg Ala Thr Pro Leu Leu Gln Thr Ala Glu Ile Met Thr Pro 
        35                  40                  45              


Pro Thr Lys Thr Leu Trp Pro Lys Gly Ser Asn Ala Ser Leu Ala Arg 
    50                  55                  60                  


Ser Leu Ala Pro Ala Glu Val Pro Lys Gly Asp Arg Thr Ala Gly Ser 
65                  70                  75                  80  


Pro Pro Arg Thr Ile Ser Pro Pro Pro Cys Gln Gly Pro Ile Glu Ile 
                85                  90                  95      


Lys Glu Thr Phe Lys Tyr Ile Asn Thr Val Val Ser Cys Leu Val Phe 
            100                 105                 110         


Val Leu Gly Ile Ile Gly Asn Ser Thr Leu Leu Arg Ile Ile Tyr Lys 
        115                 120                 125             


Asn Lys Cys Met Arg Asn Gly Pro Asn Ile Leu Ile Ala Ser Leu Ala 
    130                 135                 140                 


Leu Gly Asp Leu Leu His Ile Val Ile Asp Ile Pro Ile Asn Val Tyr 
145                 150                 155                 160 


Lys Leu Leu Ala Glu Asp Trp Pro Phe Gly Ala Glu Met Cys Lys Leu 
                165                 170                 175     


Val Pro Phe Ile Gln Lys Ala Ser Val Gly Ile Thr Val Leu Ser Leu 
            180                 185                 190         


Cys Ala Leu Ser Ile Asp Arg Tyr Arg Ala Val Ala Ser Trp Ser Arg 
        195                 200                 205             


Ile Lys Gly Ile Gly Val Pro Lys Trp Thr Ala Val Glu Ile Val Leu 
    210                 215                 220                 


Ile Trp Val Val Ser Val Val Leu Ala Val Pro Glu Ala Ile Gly Phe 
225                 230                 235                 240 


Asp Ile Ile Thr Met Asp Tyr Lys Gly Ser Tyr Leu Arg Ile Cys Leu 
                245                 250                 255     


Leu His Pro Val Gln Lys Thr Ala Phe Met Gln Phe Tyr Lys Thr Ala 
            260                 265                 270         


Lys Asp Trp Trp Leu Phe Ser Phe Tyr Phe Cys Leu Pro Leu Ala Ile 
        275                 280                 285             


Thr Ala Phe Phe Tyr Thr Leu Met Thr Cys Glu Met Leu Arg Lys Lys 
    290                 295                 300                 


Ser Gly Met Gln Ile Ala Leu Asn Asp His Leu Lys Gln Arg Arg Glu 
305                 310                 315                 320 


Val Ala Lys Thr Val Phe Cys Leu Val Leu Val Phe Ala Leu Cys Trp 
                325                 330                 335     


Leu Pro Leu His Leu Ser Arg Ile Leu Lys Leu Thr Leu Tyr Asn Gln 
            340                 345                 350         


Asn Asp Pro Asn Arg Cys Glu Leu Leu Ser Phe Leu Leu Val Leu Asp 
        355                 360                 365             


Tyr Ile Gly Ile Asn Met Ala Ser Leu Asn Ser Cys Ile Asn Pro Ile 
    370                 375                 380                 


Ala Leu Tyr Leu Val Ser Lys Arg Phe Lys Asn Cys Phe Lys Ser Cys 
385                 390                 395                 400 


Leu Cys Cys Trp Cys Gln Ser Phe Glu Glu Lys Gln Ser Leu Glu Glu 
                405                 410                 415     


Lys Gln Ser Cys Leu Lys Phe Lys Ala Asn Asp His Gly Tyr Asp Asn 
            420                 425                 430         


Phe Arg Ser Ser Asn Lys Tyr Ser Ser Ser 
        435                 440         


<210>  4557
<211>  442
<212>  PRT
<213>  Homo Sapiens

<400>  4557

Met Gln Pro Pro Pro Ser Leu Cys Gly Arg Ala Leu Val Ala Leu Val 
1               5                   10                  15      


Leu Ala Cys Gly Leu Ser Arg Ile Trp Gly Glu Glu Arg Gly Phe Pro 
            20                  25                  30          


Pro Asp Arg Ala Thr Pro Leu Leu Gln Thr Ala Glu Ile Met Thr Pro 
        35                  40                  45              


Pro Thr Lys Thr Leu Trp Pro Lys Gly Ser Asn Ala Ser Leu Ala Arg 
    50                  55                  60                  


Ser Leu Ala Pro Ala Glu Val Pro Lys Gly Asp Arg Thr Ala Gly Ser 
65                  70                  75                  80  


Pro Pro Arg Thr Ile Ser Pro Pro Pro Cys Gln Gly Pro Ile Glu Ile 
                85                  90                  95      


Lys Glu Thr Phe Lys Tyr Ile Asn Thr Val Val Ser Cys Leu Val Phe 
            100                 105                 110         


Val Leu Gly Ile Ile Gly Asn Ser Thr Leu Leu Arg Ile Ile Tyr Lys 
        115                 120                 125             


Asn Lys Cys Met Arg Asn Gly Pro Asn Ile Leu Ile Ala Ser Leu Ala 
    130                 135                 140                 


Leu Gly Asp Leu Leu His Ile Val Ile Asp Ile Pro Ile Asn Val Tyr 
145                 150                 155                 160 


Lys Leu Leu Ala Glu Asp Trp Pro Phe Gly Ala Glu Met Cys Lys Leu 
                165                 170                 175     


Val Pro Phe Ile Gln Lys Ala Ser Val Gly Ile Thr Val Leu Ser Leu 
            180                 185                 190         


Cys Ala Leu Ser Ile Asp Arg Tyr Arg Ala Val Ala Ser Trp Ser Arg 
        195                 200                 205             


Ile Lys Gly Ile Gly Val Pro Lys Trp Thr Ala Val Glu Ile Val Leu 
    210                 215                 220                 


Ile Trp Val Val Ser Val Val Leu Ala Val Pro Glu Ala Ile Gly Phe 
225                 230                 235                 240 


Asp Ile Ile Thr Met Asp Tyr Lys Gly Ser Tyr Leu Arg Ile Cys Leu 
                245                 250                 255     


Leu His Pro Val Gln Lys Thr Ala Phe Met Gln Phe Tyr Lys Thr Ala 
            260                 265                 270         


Lys Asp Trp Trp Leu Phe Ser Phe Tyr Phe Cys Leu Pro Leu Ala Ile 
        275                 280                 285             


Thr Ala Phe Phe Tyr Thr Leu Met Thr Cys Glu Met Leu Arg Lys Lys 
    290                 295                 300                 


Ser Gly Met Gln Ile Ala Leu Asn Asp His Leu Lys Gln Arg Arg Glu 
305                 310                 315                 320 


Val Ala Lys Thr Val Phe Cys Leu Val Leu Val Phe Ala Leu Cys Trp 
                325                 330                 335     


Leu Pro Leu His Leu Ser Arg Ile Leu Lys Leu Thr Leu Tyr Asn Gln 
            340                 345                 350         


Asn Asp Pro Asn Arg Cys Glu Leu Leu Ser Phe Leu Leu Val Leu Asp 
        355                 360                 365             


Tyr Ile Gly Ile Asn Met Ala Ser Leu Asn Ser Cys Ile Asn Pro Ile 
    370                 375                 380                 


Ala Leu Tyr Leu Val Ser Lys Arg Phe Lys Asn Cys Phe Lys Ser Cys 
385                 390                 395                 400 


Leu Cys Cys Trp Cys Gln Ser Phe Glu Glu Lys Gln Ser Leu Glu Glu 
                405                 410                 415     


Lys Gln Ser Cys Leu Lys Phe Lys Ala Asn Asp His Gly Tyr Asp Asn 
            420                 425                 430         


Phe Arg Ser Ser Asn Lys Tyr Ser Ser Ser 
        435                 440         


<210>  4558
<211>  27
<212>  PRT
<213>  Homo Sapiens

<400>  4558

Met Leu Lys Ala Leu Phe Leu Thr Met Leu Thr Leu Ala Leu Val Lys 
1               5                   10                  15      


Ser Gln Asp Thr Glu Glu Thr Ile Thr Tyr Thr 
            20                  25          


<210>  4559
<211>  52
<212>  PRT
<213>  Homo Sapiens

<400>  4559

Met Leu Lys Ala Leu Phe Leu Thr Met Leu Thr Leu Ala Leu Val Lys 
1               5                   10                  15      


Ser Gln Asp Thr Glu Glu Thr Ile Thr Tyr Thr Gln Cys Thr Asp Gly 
            20                  25                  30          


Tyr Glu Trp Asp Pro Val Arg Gln Gln Cys Lys Asp Ile Asp Glu Cys 
        35                  40                  45              


Asp Ile Val Pro 
    50          


<210>  4560
<211>  62
<212>  PRT
<213>  Homo Sapiens

<400>  4560

Met Leu Lys Ala Leu Phe Leu Thr Met Leu Thr Leu Ala Leu Val Lys 
1               5                   10                  15      


Ser Gln Asp Thr Glu Glu Thr Ile Thr Tyr Thr Gln Cys Thr Asp Gly 
            20                  25                  30          


Tyr Glu Trp Asp Pro Val Arg Gln Gln Cys Lys Asp Ile Asp Glu Cys 
        35                  40                  45              


Asp Ile Val Pro Asp Ala Cys Lys Gly Gly Met Lys Cys Val 
    50                  55                  60          


<210>  4561
<211>  87
<212>  PRT
<213>  Homo Sapiens

<400>  4561

Met Leu Lys Ala Leu Phe Leu Thr Met Leu Thr Leu Ala Leu Val Lys 
1               5                   10                  15      


Ser Gln Asp Thr Glu Glu Thr Ile Thr Tyr Thr Gln Cys Thr Asp Gly 
            20                  25                  30          


Tyr Glu Trp Asp Pro Val Arg Gln Gln Cys Lys Asp Ile Asp Glu Cys 
        35                  40                  45              


Asp Ile Val Pro Asp Ala Cys Lys Gly Gly Met Lys Cys Val Asn His 
    50                  55                  60                  


Tyr Gly Gly Tyr Leu Cys Leu Pro Lys Thr Ala Gln Ile Ile Val Asn 
65                  70                  75                  80  


Asn Glu Gln Pro Gln Gln Glu 
                85          


<210>  4562
<211>  106
<212>  PRT
<213>  Homo Sapiens

<400>  4562

Met Leu Lys Ala Leu Phe Leu Thr Met Leu Thr Leu Ala Leu Val Lys 
1               5                   10                  15      


Ser Gln Asp Thr Glu Glu Thr Ile Thr Tyr Thr Gln Cys Thr Asp Gly 
            20                  25                  30          


Tyr Glu Trp Asp Pro Val Arg Gln Gln Cys Lys Asp Ile Asp Glu Cys 
        35                  40                  45              


Asp Ile Val Pro Asp Ala Cys Lys Gly Gly Met Lys Cys Val Asn His 
    50                  55                  60                  


Tyr Gly Gly Tyr Leu Cys Leu Pro Lys Thr Ala Gln Ile Ile Val Asn 
65                  70                  75                  80  


Asn Glu Gln Pro Gln Gln Glu Thr Gln Pro Ala Glu Gly Thr Ser Gly 
                85                  90                  95      


Ala Thr Thr Gly Val Val Ala Ala Ser Ser 
            100                 105     


<210>  4563
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  4563

Met Leu Lys Ala Leu Phe Leu Thr Met Leu Thr Leu Ala Leu Val Lys 
1               5                   10                  15      


Ser Gln Asp Thr Glu Glu Thr Ile Thr Tyr Thr Gln Cys Thr Asp Gly 
            20                  25                  30          


Tyr Glu Trp Asp Pro Val Arg Gln Gln Cys Lys Asp Ile Asp Glu Cys 
        35                  40                  45              


Asp Ile Val Pro Asp Ala Cys Lys Gly Gly Met Lys Cys Val Asn His 
    50                  55                  60                  


Tyr Gly Gly Tyr Leu Cys Leu Pro Lys Thr Ala Gln Ile Ile Val Asn 
65                  70                  75                  80  


Asn Glu Gln Pro Gln Gln Glu Thr Gln Pro Ala Glu Gly Thr Ser Gly 
                85                  90                  95      


Ala Thr Thr Gly Val Val Ala Ala Ser Ser Met Ala Thr Ser Gly Val 
            100                 105                 110         


Leu Pro Gly Gly Gly Phe Val 
        115                 


<210>  4564
<211>  172
<212>  PRT
<213>  Homo Sapiens

<400>  4564

Met Leu Lys Ala Leu Phe Leu Thr Met Leu Thr Leu Ala Leu Val Lys 
1               5                   10                  15      


Ser Gln Asp Thr Glu Glu Thr Ile Thr Tyr Thr Gln Cys Thr Asp Gly 
            20                  25                  30          


Tyr Glu Trp Asp Pro Val Arg Gln Gln Cys Lys Asp Ile Asp Glu Cys 
        35                  40                  45              


Asp Ile Val Pro Asp Ala Cys Lys Gly Gly Met Lys Cys Val Asn His 
    50                  55                  60                  


Tyr Gly Gly Tyr Leu Cys Leu Pro Lys Thr Ala Gln Ile Ile Val Asn 
65                  70                  75                  80  


Asn Glu Gln Pro Gln Gln Glu Thr Gln Pro Ala Glu Gly Thr Ser Gly 
                85                  90                  95      


Ala Thr Thr Gly Val Val Ala Ala Ser Ser Met Ala Thr Ser Gly Val 
            100                 105                 110         


Leu Pro Gly Gly Gly Phe Val Ala Ser Ala Ala Ala Val Ala Gly Pro 
        115                 120                 125             


Glu Met Gln Thr Gly Arg Asn Asn Phe Val Ile Arg Arg Asn Pro Ala 
    130                 135                 140                 


Asp Pro Gln Arg Ile Pro Ser Asn Pro Ser His Arg Ile Gln Cys Ala 
145                 150                 155                 160 


Ala Gly Tyr Glu Gln Ser Glu His Asn Val Cys Gln 
                165                 170         


<210>  4565
<211>  493
<212>  PRT
<213>  Homo Sapiens

<400>  4565

Met Leu Lys Ala Leu Phe Leu Thr Met Leu Thr Leu Ala Leu Val Lys 
1               5                   10                  15      


Ser Gln Asp Thr Glu Glu Thr Ile Thr Tyr Thr Gln Cys Thr Asp Gly 
            20                  25                  30          


Tyr Glu Trp Asp Pro Val Arg Gln Gln Cys Lys Asp Ile Asp Glu Cys 
        35                  40                  45              


Asp Ile Val Pro Asp Ala Cys Lys Gly Gly Met Lys Cys Val Asn His 
    50                  55                  60                  


Tyr Gly Gly Tyr Leu Cys Leu Pro Lys Thr Ala Gln Ile Ile Val Asn 
65                  70                  75                  80  


Asn Glu Gln Pro Gln Gln Glu Thr Gln Pro Ala Glu Gly Thr Ser Gly 
                85                  90                  95      


Ala Thr Thr Gly Val Val Ala Ala Ser Ser Met Ala Thr Ser Gly Val 
            100                 105                 110         


Leu Pro Gly Gly Gly Phe Val Ala Ser Ala Ala Ala Val Ala Gly Pro 
        115                 120                 125             


Glu Met Gln Thr Gly Arg Asn Asn Phe Val Ile Arg Arg Asn Pro Ala 
    130                 135                 140                 


Asp Pro Gln Arg Ile Pro Ser Asn Pro Ser His Arg Ile Gln Cys Ala 
145                 150                 155                 160 


Ala Gly Tyr Glu Gln Ser Glu His Asn Val Cys Gln Asp Ile Asp Glu 
                165                 170                 175     


Cys Thr Ala Gly Thr His Asn Cys Arg Ala Asp Gln Val Cys Ile Asn 
            180                 185                 190         


Leu Arg Gly Ser Phe Ala Cys Gln Cys Pro Pro Gly Tyr Gln Lys Arg 
        195                 200                 205             


Gly Glu Gln Cys Val Asp Ile Asp Glu Cys Thr Ile Pro Pro Tyr Cys 
    210                 215                 220                 


His Gln Arg Cys Val Asn Thr Pro Gly Ser Phe Tyr Cys Gln Cys Ser 
225                 230                 235                 240 


Pro Gly Phe Gln Leu Ala Ala Asn Asn Tyr Thr Cys Val Asp Ile Asn 
                245                 250                 255     


Glu Cys Asp Ala Ser Asn Gln Cys Ala Gln Gln Cys Tyr Asn Ile Leu 
            260                 265                 270         


Gly Ser Phe Ile Cys Gln Cys Asn Gln Gly Tyr Glu Leu Ser Ser Asp 
        275                 280                 285             


Arg Leu Asn Cys Glu Asp Ile Asp Glu Cys Arg Thr Ser Ser Tyr Leu 
    290                 295                 300                 


Cys Gln Tyr Gln Cys Val Asn Glu Pro Gly Lys Phe Ser Cys Met Cys 
305                 310                 315                 320 


Pro Gln Gly Tyr Gln Val Val Arg Ser Arg Thr Cys Gln Asp Ile Asn 
                325                 330                 335     


Glu Cys Glu Thr Thr Asn Glu Cys Arg Glu Asp Glu Met Cys Trp Asn 
            340                 345                 350         


Tyr His Gly Gly Phe Arg Cys Tyr Pro Arg Asn Pro Cys Gln Asp Pro 
        355                 360                 365             


Tyr Ile Leu Thr Pro Glu Asn Arg Cys Val Cys Pro Val Ser Asn Ala 
    370                 375                 380                 


Met Cys Arg Glu Leu Pro Gln Ser Ile Val Tyr Lys Tyr Met Ser Ile 
385                 390                 395                 400 


Arg Ser Asp Arg Ser Val Pro Ser Asp Ile Phe Gln Ile Gln Ala Thr 
                405                 410                 415     


Thr Ile Tyr Ala Asn Thr Ile Asn Thr Phe Arg Ile Lys Ser Gly Asn 
            420                 425                 430         


Glu Asn Gly Glu Phe Tyr Leu Arg Gln Thr Ser Pro Val Ser Ala Met 
        435                 440                 445             


Leu Val Leu Val Lys Ser Leu Ser Gly Pro Arg Glu His Ile Val Asp 
    450                 455                 460                 


Leu Glu Met Leu Thr Val Ser Ser Ile Gly Thr Phe Arg Thr Ser Ser 
465                 470                 475                 480 


Val Leu Arg Leu Thr Ile Ile Val Gly Pro Phe Ser Phe 
                485                 490             


<210>  4566
<211>  493
<212>  PRT
<213>  Homo Sapiens

<400>  4566

Met Leu Lys Ala Leu Phe Leu Thr Met Leu Thr Leu Ala Leu Val Lys 
1               5                   10                  15      


Ser Gln Asp Thr Glu Glu Thr Ile Thr Tyr Thr Gln Cys Thr Asp Gly 
            20                  25                  30          


Tyr Glu Trp Asp Pro Val Arg Gln Gln Cys Lys Asp Ile Asp Glu Cys 
        35                  40                  45              


Asp Ile Val Pro Asp Ala Cys Lys Gly Gly Met Lys Cys Val Asn His 
    50                  55                  60                  


Tyr Gly Gly Tyr Leu Cys Leu Pro Lys Thr Ala Gln Ile Ile Val Asn 
65                  70                  75                  80  


Asn Glu Gln Pro Gln Gln Glu Thr Gln Pro Ala Glu Gly Thr Ser Gly 
                85                  90                  95      


Ala Thr Thr Gly Val Val Ala Ala Ser Ser Met Ala Thr Ser Gly Val 
            100                 105                 110         


Leu Pro Gly Gly Gly Phe Val Ala Ser Ala Ala Ala Val Ala Gly Pro 
        115                 120                 125             


Glu Met Gln Thr Gly Arg Asn Asn Phe Val Ile Arg Arg Asn Pro Ala 
    130                 135                 140                 


Asp Pro Gln Arg Ile Pro Ser Asn Pro Ser His Arg Ile Gln Cys Ala 
145                 150                 155                 160 


Ala Gly Tyr Glu Gln Ser Glu His Asn Val Cys Gln Asp Ile Asp Glu 
                165                 170                 175     


Cys Thr Ala Gly Thr His Asn Cys Arg Ala Asp Gln Val Cys Ile Asn 
            180                 185                 190         


Leu Arg Gly Ser Phe Ala Cys Gln Cys Pro Pro Gly Tyr Gln Lys Arg 
        195                 200                 205             


Gly Glu Gln Cys Val Asp Ile Asp Glu Cys Thr Ile Pro Pro Tyr Cys 
    210                 215                 220                 


His Gln Arg Cys Val Asn Thr Pro Gly Ser Phe Tyr Cys Gln Cys Ser 
225                 230                 235                 240 


Pro Gly Phe Gln Leu Ala Ala Asn Asn Tyr Thr Cys Val Asp Ile Asn 
                245                 250                 255     


Glu Cys Asp Ala Ser Asn Gln Cys Ala Gln Gln Cys Tyr Asn Ile Leu 
            260                 265                 270         


Gly Ser Phe Ile Cys Gln Cys Asn Gln Gly Tyr Glu Leu Ser Ser Asp 
        275                 280                 285             


Arg Leu Asn Cys Glu Asp Ile Asp Glu Cys Arg Thr Ser Ser Tyr Leu 
    290                 295                 300                 


Cys Gln Tyr Gln Cys Val Asn Glu Pro Gly Lys Phe Ser Cys Met Cys 
305                 310                 315                 320 


Pro Gln Gly Tyr Gln Val Val Arg Ser Arg Thr Cys Gln Asp Ile Asn 
                325                 330                 335     


Glu Cys Glu Thr Thr Asn Glu Cys Arg Glu Asp Glu Met Cys Trp Asn 
            340                 345                 350         


Tyr His Gly Gly Phe Arg Cys Tyr Pro Arg Asn Pro Cys Gln Asp Pro 
        355                 360                 365             


Tyr Ile Leu Thr Pro Glu Asn Arg Cys Val Cys Pro Val Ser Asn Ala 
    370                 375                 380                 


Met Cys Arg Glu Leu Pro Gln Ser Ile Val Tyr Lys Tyr Met Ser Ile 
385                 390                 395                 400 


Arg Ser Asp Arg Ser Val Pro Ser Asp Ile Phe Gln Ile Gln Ala Thr 
                405                 410                 415     


Thr Ile Tyr Ala Asn Thr Ile Asn Thr Phe Arg Ile Lys Ser Gly Asn 
            420                 425                 430         


Glu Asn Gly Glu Phe Tyr Leu Arg Gln Thr Ser Pro Val Ser Ala Met 
        435                 440                 445             


Leu Val Leu Val Lys Ser Leu Ser Gly Pro Arg Glu His Ile Val Asp 
    450                 455                 460                 


Leu Glu Met Leu Thr Val Ser Ser Ile Gly Thr Phe Arg Thr Ser Ser 
465                 470                 475                 480 


Val Leu Arg Leu Thr Ile Ile Val Gly Pro Phe Ser Phe 
                485                 490             


<210>  4567
<211>  46
<212>  PRT
<213>  Homo Sapiens

<400>  4567

Met Leu Lys Ala Leu Phe Leu Thr Met Leu Thr Leu Ala Leu Val Lys 
1               5                   10                  15      


Ser Gln Asp Thr Glu Glu Thr Ile Thr Tyr Thr Gln Cys Thr Asp Gly 
            20                  25                  30          


Tyr Glu Trp Asp Pro Val Arg Gln Gln Cys Lys Glu Asp Ser 
        35                  40                  45      


<210>  4568
<211>  280
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4568

Xaa Asn Asn Phe Val Ile Arg Arg Asn Pro Ala Asp Pro Gln Arg Ile 
1               5                   10                  15      


Pro Ser Asn Pro Ser His Arg Ile Gln Cys Ala Ala Gly Tyr Glu Gln 
            20                  25                  30          


Ser Glu His Asn Val Cys Gln Asp Ile Asp Glu Cys Thr Ala Gly Thr 
        35                  40                  45              


His Asn Cys Arg Ala Asp Gln Val Cys Ile Asn Leu Arg Gly Ser Phe 
    50                  55                  60                  


Ala Cys Gln Cys Pro Pro Gly Tyr Gln Lys Arg Gly Glu Gln Cys Val 
65                  70                  75                  80  


Asp Ile Asp Glu Cys Arg Thr Ser Ser Tyr Leu Cys Gln Tyr Gln Cys 
                85                  90                  95      


Val Asn Glu Pro Gly Lys Phe Ser Cys Met Cys Pro Gln Gly Tyr Gln 
            100                 105                 110         


Val Val Arg Ser Arg Thr Cys Gln Asp Ile Asn Glu Cys Glu Thr Thr 
        115                 120                 125             


Asn Glu Cys Arg Glu Asp Glu Met Cys Trp Asn Tyr His Gly Gly Phe 
    130                 135                 140                 


Arg Cys Tyr Pro Arg Asn Pro Cys Gln Asp Pro Tyr Ile Leu Thr Pro 
145                 150                 155                 160 


Glu Asn Arg Cys Val Cys Pro Val Ser Asn Ala Met Cys Arg Glu Leu 
                165                 170                 175     


Pro Gln Ser Ile Val Tyr Lys Tyr Met Ser Ile Arg Ser Asp Arg Ser 
            180                 185                 190         


Val Pro Ser Asp Ile Phe Gln Ile Gln Ala Thr Thr Ile Tyr Ala Asn 
        195                 200                 205             


Thr Ile Asn Thr Phe Arg Ile Lys Ser Gly Asn Glu Asn Gly Glu Phe 
    210                 215                 220                 


Tyr Leu Arg Gln Thr Ser Pro Val Ser Ala Met Leu Val Leu Val Lys 
225                 230                 235                 240 


Ser Leu Ser Gly Pro Arg Glu His Ile Val Asp Leu Glu Met Leu Thr 
                245                 250                 255     


Val Ser Ser Ile Gly Thr Phe Arg Thr Ser Ser Val Leu Arg Leu Thr 
            260                 265                 270         


Ile Ile Val Gly Pro Phe Ser Phe 
        275                 280 


<210>  4569
<211>  182
<212>  PRT
<213>  Homo Sapiens

<400>  4569

Asp Glu Cys Glu Ser Gly Ala His Gln Cys Ser Glu Ala Gln Thr Cys 
1               5                   10                  15      


Val Asn Phe His Gly Gly Tyr Arg Cys Val Asp Thr Asn Arg Cys Val 
            20                  25                  30          


Glu Pro Tyr Ile Gln Val Ser Glu Asn Arg Cys Leu Cys Pro Ala Ser 
        35                  40                  45              


Asn Pro Leu Cys Arg Glu Gln Pro Ser Ser Ile Val His Arg Tyr Met 
    50                  55                  60                  


Thr Ile Thr Ser Glu Arg Ser Val Pro Ala Asp Val Phe Gln Ile Gln 
65                  70                  75                  80  


Ala Thr Ser Val Tyr Pro Gly Ala Tyr Asn Ala Phe Gln Ile Arg Ala 
                85                  90                  95      


Gly Asn Ser Gln Gly Asp Phe Tyr Ile Arg Gly Pro Thr Pro Ser Glu 
            100                 105                 110         


Glu Gln Glu Gly Ala Thr Leu Pro Ala Ala Thr Leu Ala Glu Glu Pro 
        115                 120                 125             


Val Val Arg Gly Arg Met Arg Lys Ala Gln Gly Pro Pro Leu Thr Gly 
    130                 135                 140                 


Ala Gly Ser Ser Ala Pro Arg Ala Ser Val Thr Pro Arg Gly Glu Glu 
145                 150                 155                 160 


Val Thr Arg Arg Ala Asp Ser Arg Pro Arg Pro Arg Asp Leu Asp Leu 
                165                 170                 175     


Ala Gly Leu Gln Gly Ser 
            180         


<210>  4570
<211>  183
<212>  PRT
<213>  Homo Sapiens

<400>  4570

Met Leu Pro Cys Ala Ser Cys Leu Pro Gly Ser Leu Leu Leu Trp Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gly Ser Ala Ser Pro Gln Asp Ser Glu Glu 
            20                  25                  30          


Pro Asp Ser Tyr Thr Glu Cys Thr Asp Gly Tyr Glu Trp Asp Pro Asp 
        35                  40                  45              


Ser Gln His Cys Arg Asp Val Asn Glu Cys Leu Thr Ile Pro Glu Ala 
    50                  55                  60                  


Cys Lys Gly Glu Met Lys Cys Ile Asn His Tyr Gly Gly Tyr Leu Cys 
65                  70                  75                  80  


Leu Pro Arg Ser Ala Ala Val Ile Asn Asp Leu His Gly Glu Gly Pro 
                85                  90                  95      


Pro Pro Pro Val Pro Pro Ala Gln His Pro Asn Pro Cys Pro Pro Gly 
            100                 105                 110         


Tyr Glu Pro Asp Asp Gln Asp Ser Cys Val Asp Val Asp Glu Cys Ala 
        115                 120                 125             


Gln Ala Leu His Asp Cys Arg Pro Ser Gln Asp Cys His Asn Leu Pro 
    130                 135                 140                 


Gly Ser Tyr Gln Cys Thr Cys Pro Asp Gly Tyr Arg Lys Ile Gly Pro 
145                 150                 155                 160 


Glu Cys Val Asp Ile Asp Glu Cys Arg Tyr Arg Tyr Cys Gln His Arg 
                165                 170                 175     


Cys Val Asn Leu Pro Gly Ser 
            180             


<210>  4571
<211>  202
<212>  PRT
<213>  Homo Sapiens

<400>  4571

Met Leu Pro Cys Ala Ser Cys Leu Pro Gly Ser Leu Leu Leu Trp Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gly Ser Ala Ser Pro Gln Asp Ser Glu Glu 
            20                  25                  30          


Pro Asp Ser Tyr Thr Glu Cys Thr Asp Gly Tyr Glu Trp Asp Pro Asp 
        35                  40                  45              


Ser Gln His Cys Arg Asp Val Asn Glu Cys Leu Thr Ile Pro Glu Ala 
    50                  55                  60                  


Cys Lys Gly Glu Met Lys Cys Ile Asn His Tyr Gly Gly Tyr Leu Cys 
65                  70                  75                  80  


Leu Pro Arg Ser Ala Ala Val Ile Asn Asp Leu His Gly Glu Gly Pro 
                85                  90                  95      


Pro Pro Pro Val Pro Pro Ala Gln His Pro Asn Pro Cys Pro Pro Gly 
            100                 105                 110         


Tyr Glu Pro Asp Asp Gln Asp Ser Cys Val Asp Val Asp Glu Cys Ala 
        115                 120                 125             


Gln Ala Leu His Asp Cys Arg Pro Ser Gln Asp Cys His Asn Leu Pro 
    130                 135                 140                 


Gly Ser Tyr Gln Cys Thr Cys Pro Asp Gly Tyr Arg Lys Ile Gly Pro 
145                 150                 155                 160 


Glu Cys Val Asp Ile Asp Glu Cys Arg Tyr Arg Tyr Cys Gln His Arg 
                165                 170                 175     


Cys Val Asn Leu Pro Gly Ser Phe Arg Cys Gln Cys Glu Pro Gly Phe 
            180                 185                 190         


Gln Leu Gly Pro Asn Asn Arg Ser Cys Val 
        195                 200         


<210>  4572
<211>  443
<212>  PRT
<213>  Homo Sapiens

<400>  4572

Met Leu Pro Cys Ala Ser Cys Leu Pro Gly Ser Leu Leu Leu Trp Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gly Ser Ala Ser Pro Gln Asp Ser Glu Glu 
            20                  25                  30          


Pro Asp Ser Tyr Thr Glu Cys Thr Asp Gly Tyr Glu Trp Asp Pro Asp 
        35                  40                  45              


Ser Gln His Cys Arg Asp Val Asn Glu Cys Leu Thr Ile Pro Glu Ala 
    50                  55                  60                  


Cys Lys Gly Glu Met Lys Cys Ile Asn His Tyr Gly Gly Tyr Leu Cys 
65                  70                  75                  80  


Leu Pro Arg Ser Ala Ala Val Ile Asn Asp Leu His Gly Glu Gly Pro 
                85                  90                  95      


Pro Pro Pro Val Pro Pro Ala Gln His Pro Asn Pro Cys Pro Pro Gly 
            100                 105                 110         


Tyr Glu Pro Asp Asp Gln Asp Ser Cys Val Asp Val Asp Glu Cys Ala 
        115                 120                 125             


Gln Ala Leu His Asp Cys Arg Pro Ser Gln Asp Cys His Asn Leu Pro 
    130                 135                 140                 


Gly Ser Tyr Gln Cys Thr Cys Pro Asp Gly Tyr Arg Lys Ile Gly Pro 
145                 150                 155                 160 


Glu Cys Val Asp Ile Asp Glu Cys Arg Tyr Arg Tyr Cys Gln His Arg 
                165                 170                 175     


Cys Val Asn Leu Pro Gly Ser Phe Arg Cys Gln Cys Glu Pro Gly Phe 
            180                 185                 190         


Gln Leu Gly Pro Asn Asn Arg Ser Cys Val Asp Val Asn Glu Cys Asp 
        195                 200                 205             


Met Gly Ala Pro Cys Glu Gln Arg Cys Phe Asn Ser Tyr Gly Thr Phe 
    210                 215                 220                 


Leu Cys Arg Cys His Gln Gly Tyr Glu Leu His Arg Asp Gly Phe Ser 
225                 230                 235                 240 


Cys Ser Asp Ile Asp Glu Cys Ser Tyr Ser Ser Tyr Leu Cys Gln Tyr 
                245                 250                 255     


Arg Cys Ile Asn Glu Pro Gly Arg Phe Ser Cys His Cys Pro Gln Gly 
            260                 265                 270         


Tyr Gln Leu Leu Ala Thr Arg Leu Cys Gln Asp Ile Asp Glu Cys Glu 
        275                 280                 285             


Ser Gly Ala His Gln Cys Ser Glu Ala Gln Thr Cys Val Asn Phe His 
    290                 295                 300                 


Gly Gly Tyr Arg Cys Val Asp Thr Asn Arg Cys Val Glu Pro Tyr Ile 
305                 310                 315                 320 


Gln Val Ser Glu Asn Arg Cys Leu Cys Pro Ala Ser Asn Pro Leu Cys 
                325                 330                 335     


Arg Glu Gln Pro Ser Ser Ile Val His Arg Tyr Met Thr Ile Thr Ser 
            340                 345                 350         


Glu Arg Ser Val Pro Ala Asp Val Phe Gln Ile Gln Ala Thr Ser Val 
        355                 360                 365             


Tyr Pro Gly Ala Tyr Asn Ala Phe Gln Ile Arg Ala Gly Asn Ser Gln 
    370                 375                 380                 


Gly Asp Phe Tyr Ile Arg Gln Ile Asn Asn Val Ser Ala Met Leu Val 
385                 390                 395                 400 


Leu Ala Arg Pro Val Thr Gly Pro Arg Glu Tyr Val Leu Asp Leu Glu 
                405                 410                 415     


Met Val Thr Met Asn Ser Leu Met Ser Tyr Arg Ala Ser Ser Val Leu 
            420                 425                 430         


Arg Leu Thr Val Phe Val Gly Ala Tyr Thr Phe 
        435                 440             


<210>  4573
<211>  443
<212>  PRT
<213>  Homo Sapiens

<400>  4573

Met Leu Pro Cys Ala Ser Cys Leu Pro Gly Ser Leu Leu Leu Trp Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gly Ser Ala Ser Pro Gln Asp Ser Glu Glu 
            20                  25                  30          


Pro Asp Ser Tyr Thr Glu Cys Thr Asp Gly Tyr Glu Trp Asp Pro Asp 
        35                  40                  45              


Ser Gln His Cys Arg Asp Val Asn Glu Cys Leu Thr Ile Pro Glu Ala 
    50                  55                  60                  


Cys Lys Gly Glu Met Lys Cys Ile Asn His Tyr Gly Gly Tyr Leu Cys 
65                  70                  75                  80  


Leu Pro Arg Ser Ala Ala Val Ile Asn Asp Leu His Gly Glu Gly Pro 
                85                  90                  95      


Pro Pro Pro Val Pro Pro Ala Gln His Pro Asn Pro Cys Pro Pro Gly 
            100                 105                 110         


Tyr Glu Pro Asp Asp Gln Asp Ser Cys Val Asp Val Asp Glu Cys Ala 
        115                 120                 125             


Gln Ala Leu His Asp Cys Arg Pro Ser Gln Asp Cys His Asn Leu Pro 
    130                 135                 140                 


Gly Ser Tyr Gln Cys Thr Cys Pro Asp Gly Tyr Arg Lys Ile Gly Pro 
145                 150                 155                 160 


Glu Cys Val Asp Ile Asp Glu Cys Arg Tyr Arg Tyr Cys Gln His Arg 
                165                 170                 175     


Cys Val Asn Leu Pro Gly Ser Phe Arg Cys Gln Cys Glu Pro Gly Phe 
            180                 185                 190         


Gln Leu Gly Pro Asn Asn Arg Ser Cys Val Asp Val Asn Glu Cys Asp 
        195                 200                 205             


Met Gly Ala Pro Cys Glu Gln Arg Cys Phe Asn Ser Tyr Gly Thr Phe 
    210                 215                 220                 


Leu Cys Arg Cys His Gln Gly Tyr Glu Leu His Arg Asp Gly Phe Ser 
225                 230                 235                 240 


Cys Ser Asp Ile Asp Glu Cys Ser Tyr Ser Ser Tyr Leu Cys Gln Tyr 
                245                 250                 255     


Arg Cys Ile Asn Glu Pro Gly Arg Phe Ser Cys His Cys Pro Gln Gly 
            260                 265                 270         


Tyr Gln Leu Leu Ala Thr Arg Leu Cys Gln Asp Ile Asp Glu Cys Glu 
        275                 280                 285             


Ser Gly Ala His Gln Cys Ser Glu Ala Gln Thr Cys Val Asn Phe His 
    290                 295                 300                 


Gly Gly Tyr Arg Cys Val Asp Thr Asn Arg Cys Val Glu Pro Tyr Ile 
305                 310                 315                 320 


Gln Val Ser Glu Asn Arg Cys Leu Cys Pro Ala Ser Asn Pro Leu Cys 
                325                 330                 335     


Arg Glu Gln Pro Ser Ser Ile Val His Arg Tyr Met Thr Ile Thr Ser 
            340                 345                 350         


Glu Arg Ser Val Pro Ala Asp Val Phe Gln Ile Gln Ala Thr Ser Val 
        355                 360                 365             


Tyr Pro Gly Ala Tyr Asn Ala Phe Gln Ile Arg Ala Gly Asn Ser Gln 
    370                 375                 380                 


Gly Asp Phe Tyr Ile Arg Gln Ile Asn Asn Val Ser Ala Met Leu Val 
385                 390                 395                 400 


Leu Ala Arg Pro Val Thr Gly Pro Arg Glu Tyr Val Leu Asp Leu Glu 
                405                 410                 415     


Met Val Thr Met Asn Ser Leu Met Ser Tyr Arg Ala Ser Ser Val Leu 
            420                 425                 430         


Arg Leu Thr Val Phe Val Gly Ala Tyr Thr Phe 
        435                 440             


<210>  4574
<211>  436
<212>  PRT
<213>  Homo Sapiens

<400>  4574

Met Leu Pro Cys Ala Ser Cys Leu Pro Gly Ser Leu Leu Leu Trp Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gly Ser Ala Ser Pro Gln Asp Ser Glu Glu 
            20                  25                  30          


Pro Asp Ser Tyr Thr Glu Cys Thr Asp Gly Tyr Glu Trp Asp Pro Asp 
        35                  40                  45              


Ser Gln His Cys Arg Asp Val Asn Glu Cys Leu Thr Ile Pro Glu Ala 
    50                  55                  60                  


Cys Lys Gly Glu Met Lys Cys Ile Asn His Tyr Gly Gly Tyr Leu Cys 
65                  70                  75                  80  


Leu Pro Arg Ser Ala Ala Val Ile Asn Asp Leu His Gly Glu Gly Pro 
                85                  90                  95      


Pro Pro Pro Val Pro Pro Ala Gln His Pro Asn Pro Cys Pro Pro Gly 
            100                 105                 110         


Tyr Glu Pro Asp Asp Gln Asp Ser Cys Val Asp Val Asp Glu Cys Ala 
        115                 120                 125             


Gln Ala Leu His Asp Cys Arg Pro Ser Gln Asp Cys His Asn Leu Pro 
    130                 135                 140                 


Gly Ser Tyr Gln Cys Thr Cys Pro Asp Gly Tyr Arg Lys Ile Gly Pro 
145                 150                 155                 160 


Glu Cys Val Asp Ile Asp Glu Cys Arg Tyr Arg Tyr Cys Gln His Arg 
                165                 170                 175     


Cys Val Asn Leu Pro Gly Ser Phe Arg Cys Gln Cys Glu Pro Gly Phe 
            180                 185                 190         


Gln Leu Gly Pro Asn Asn Arg Ser Cys Val Asp Val Asn Glu Cys Asp 
        195                 200                 205             


Met Gly Ala Pro Cys Glu Gln Arg Cys Phe Asn Ser Tyr Gly Thr Phe 
    210                 215                 220                 


Leu Cys Arg Cys His Gln Gly Tyr Glu Leu His Arg Asp Gly Phe Ser 
225                 230                 235                 240 


Cys Ser Asp Ile Asp Glu Cys Ser Tyr Ser Ser Tyr Leu Cys Gln Tyr 
                245                 250                 255     


Arg Cys Ile Asn Glu Pro Gly Arg Phe Ser Cys His Cys Pro Gln Gly 
            260                 265                 270         


Tyr Gln Leu Leu Ala Thr Arg Leu Cys Gln Asp Ile Asp Glu Cys Glu 
        275                 280                 285             


Ser Gly Ala His Gln Cys Ser Glu Ala Gln Thr Cys Val Asn Phe His 
    290                 295                 300                 


Gly Gly Tyr Arg Cys Val Asp Thr Asn Arg Cys Val Glu Pro Tyr Ile 
305                 310                 315                 320 


Gln Val Ser Glu Asn Arg Cys Leu Cys Pro Ala Ser Asn Pro Leu Cys 
                325                 330                 335     


Arg Glu Gln Pro Ser Ser Ile Val His Arg Tyr Met Thr Ile Thr Ser 
            340                 345                 350         


Glu Arg Ser Val Pro Ala Asp Val Phe Gln Ile Gln Ala Thr Ser Val 
        355                 360                 365             


Tyr Pro Gly Ala Tyr Asn Ala Phe Gln Ile Arg Ala Gly Asn Ser Gln 
    370                 375                 380                 


Gly Asp Phe Tyr Ile Arg Ala Gln Gly Pro Pro Leu Thr Gly Ala Gly 
385                 390                 395                 400 


Ser Ser Ala Pro Arg Ala Ser Val Thr Pro Arg Gly Glu Glu Val Thr 
                405                 410                 415     


Arg Arg Ala Asp Ser Arg Pro Arg Pro Arg Asp Leu Asp Leu Ala Gly 
            420                 425                 430         


Leu Gln Gly Ser 
        435     


<210>  4575
<211>  77
<212>  PRT
<213>  Homo Sapiens

<400>  4575

Met Leu Pro Cys Ala Ser Cys Leu Pro Gly Ser Leu Leu Leu Trp Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gly Ser Ala Ser Pro Gln Asp Ser Glu Glu 
            20                  25                  30          


Pro Asp Ser Tyr Thr Glu Cys Thr Asp Gly Tyr Glu Trp Asp Pro Asp 
        35                  40                  45              


Ser Gln His Cys Arg Gly Pro Ala Gln Glu Thr Gly Cys Ala Gln Gln 
    50                  55                  60                  


Ala Pro Leu Cys Arg Cys Gln Arg Val Ser Asp His Pro 
65                  70                  75          


<210>  4576
<211>  58
<212>  PRT
<213>  Homo Sapiens

<400>  4576

Met Leu Pro Cys Ala Ser Cys Leu Pro Gly Ser Leu Leu Leu Trp Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gly Ser Ala Ser Pro Gln Asp Ser Glu Glu 
            20                  25                  30          


Pro Asp Ser Tyr Thr Val Gly Thr Val Arg Ala Ala Gly Leu Gly Gln 
        35                  40                  45              


Glu Gly Cys Gln Arg Val Ser Asp His Pro 
    50                  55              


<210>  4577
<211>  76
<212>  PRT
<213>  Homo Sapiens

<400>  4577

Met Thr Ile Thr Ser Glu Arg Ser Val Pro Ala Asp Val Phe Gln Ile 
1               5                   10                  15      


Gln Ala Thr Ser Val Tyr Pro Gly Ala Tyr Asn Ala Phe Gln Ile Arg 
            20                  25                  30          


Ala Gly Asn Ser Gln Gly Asp Phe Tyr Ile Arg Gln Ile Asn Asn Val 
        35                  40                  45              


Ser Ala Met Leu Val Leu Ala Arg Pro Val Thr Gly Pro Arg Glu Tyr 
    50                  55                  60                  


Val Leu Asp Leu Glu Met Val Thr Met Asn Ser Leu 
65                  70                  75      


<210>  4578
<211>  74
<212>  PRT
<213>  Homo Sapiens

<400>  4578

Ser Ile Val His Arg Tyr Met Thr Ile Thr Ser Glu Arg Ser Val Pro 
1               5                   10                  15      


Ala Asp Val Phe Gln Ile Gln Ala Thr Ser Val Tyr Pro Gly Ala Tyr 
            20                  25                  30          


Asn Ala Phe Gln Ile Arg Ala Gly Asn Ser Gln Gly Asp Phe Tyr Ile 
        35                  40                  45              


Arg Gln Ile Asn Asn Val Ser Ala Met Leu Val Leu Ala Arg Pro Val 
    50                  55                  60                  


Thr Gly Pro Arg Glu Pro Arg Gly Pro His 
65                  70                  


<210>  4579
<211>  69
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4579

Xaa Phe Gln Ile Arg Ala Gly Asn Ser Gln Gly Asp Phe Tyr Ile Arg 
1               5                   10                  15      


Gln Ile Asn Asn Val Ser Ala Met Leu Val Leu Ala Arg Pro Val Thr 
            20                  25                  30          


Gly Pro Arg Glu Tyr Val Leu Asp Leu Glu Met Val Thr Met Asn Ser 
        35                  40                  45              


Leu Met Ser Tyr Arg Ala Ser Ser Val Leu Arg Leu Thr Val Phe Val 
    50                  55                  60                  


Gly Ala Tyr Thr Phe 
65                  


<210>  4580
<211>  54
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4580

Xaa Gln Ile Asn Asn Val Ser Ala Met Leu Val Leu Ala Arg Pro Val 
1               5                   10                  15      


Thr Gly Pro Arg Glu Tyr Val Leu Asp Leu Glu Met Val Thr Met Asn 
            20                  25                  30          


Ser Leu Met Ser Tyr Arg Ala Ser Ser Val Leu Arg Leu Thr Val Phe 
        35                  40                  45              


Val Gly Ala Tyr Thr Phe 
    50                  


<210>  4581
<211>  183
<212>  PRT
<213>  Homo Sapiens

<400>  4581

Met Glu Phe Leu Trp Ala Pro Leu Leu Gly Leu Cys Cys Ser Leu Ala 
1               5                   10                  15      


Ala Ala Asp Arg His Thr Val Phe Trp Asn Ser Ser Asn Pro Lys Phe 
            20                  25                  30          


Arg Asn Glu Asp Tyr Thr Ile His Val Gln Leu Asn Asp Tyr Val Asp 
        35                  40                  45              


Ile Ile Cys Pro His Tyr Glu Asp His Ser Val Ala Asp Ala Ala Met 
    50                  55                  60                  


Glu Gln Tyr Ile Leu Tyr Leu Val Glu His Glu Glu Tyr Gln Leu Cys 
65                  70                  75                  80  


Gln Pro Gln Ser Lys Asp Gln Val Arg Trp Gln Cys Asn Arg Pro Ser 
                85                  90                  95      


Ala Lys His Gly Pro Glu Lys Leu Ser Glu Lys Phe Gln Arg Phe Thr 
            100                 105                 110         


Pro Phe Thr Leu Gly Lys Glu Phe Lys Glu Gly His Ser Tyr Tyr Tyr 
        115                 120                 125             


Ile Ser His Ser Pro Gln Ala His Asp Asn Pro Gln Glu Lys Arg Leu 
    130                 135                 140                 


Ala Ala Asp Asp Pro Glu Val Arg Val Leu His Ser Ile Gly His Ser 
145                 150                 155                 160 


Ala Ala Pro Arg Leu Phe Pro Leu Ala Trp Thr Val Leu Leu Leu Pro 
                165                 170                 175     


Leu Leu Leu Leu Gln Thr Pro 
            180             


<210>  4582
<211>  205
<212>  PRT
<213>  Homo Sapiens

<400>  4582

Met Glu Phe Leu Trp Ala Pro Leu Leu Gly Leu Cys Cys Ser Leu Ala 
1               5                   10                  15      


Ala Ala Asp Arg His Thr Val Phe Trp Asn Ser Ser Asn Pro Lys Phe 
            20                  25                  30          


Arg Asn Glu Asp Tyr Thr Ile His Val Gln Leu Asn Asp Tyr Val Asp 
        35                  40                  45              


Ile Ile Cys Pro His Tyr Glu Asp His Ser Val Ala Asp Ala Ala Met 
    50                  55                  60                  


Glu Gln Tyr Ile Leu Tyr Leu Val Glu His Glu Glu Tyr Gln Leu Cys 
65                  70                  75                  80  


Gln Pro Gln Ser Lys Asp Gln Val Arg Trp Gln Cys Asn Arg Pro Ser 
                85                  90                  95      


Ala Lys His Gly Pro Glu Lys Leu Ser Glu Lys Phe Gln Arg Phe Thr 
            100                 105                 110         


Pro Phe Thr Leu Gly Lys Glu Phe Lys Glu Gly His Ser Tyr Tyr Tyr 
        115                 120                 125             


Ile Ser Lys Pro Ile His Gln His Glu Asp Arg Cys Leu Arg Leu Lys 
    130                 135                 140                 


Val Thr Val Ser Gly Lys Ile Thr His Ser Pro Gln Ala His Asp Asn 
145                 150                 155                 160 


Pro Gln Glu Lys Arg Leu Ala Ala Asp Asp Pro Glu Val Arg Val Leu 
                165                 170                 175     


His Ser Ile Gly His Ser Ala Ala Pro Arg Leu Phe Pro Leu Ala Trp 
            180                 185                 190         


Thr Val Leu Leu Leu Pro Leu Leu Leu Leu Gln Thr Pro 
        195                 200                 205 


<210>  4583
<211>  213
<212>  PRT
<213>  Homo Sapiens

<400>  4583

Met Ala Pro Ala Gln Arg Pro Leu Leu Pro Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Pro Leu Pro Pro Pro Pro Phe Ala Arg Ala Glu Asp Ala Ala Arg Ala 
            20                  25                  30          


Asn Ser Asp Arg Tyr Ala Val Tyr Trp Asn Arg Ser Asn Pro Arg Phe 
        35                  40                  45              


His Ala Gly Ala Gly Asp Asp Gly Gly Gly Tyr Thr Val Glu Val Ser 
    50                  55                  60                  


Ile Asn Asp Tyr Leu Asp Ile Tyr Cys Pro His Tyr Gly Ala Pro Leu 
65                  70                  75                  80  


Pro Pro Ala Glu Arg Met Glu His Tyr Val Leu Tyr Met Val Asn Gly 
                85                  90                  95      


Glu Gly His Ala Ser Cys Asp His Arg Gln Arg Gly Phe Lys Arg Trp 
            100                 105                 110         


Glu Cys Asn Arg Pro Ala Ala Pro Gly Gly Pro Leu Lys Phe Ser Glu 
        115                 120                 125             


Lys Phe Gln Leu Phe Thr Pro Phe Ser Leu Gly Phe Glu Phe Arg Pro 
    130                 135                 140                 


Gly His Glu Tyr Tyr Tyr Ile Ser Ala Thr Pro Pro Asn Ala Val Asp 
145                 150                 155                 160 


Arg Pro Cys Leu Arg Leu Lys Val Tyr Val Arg Pro Thr Asn Glu Thr 
                165                 170                 175     


Leu Tyr Glu Ala Pro Glu Pro Ile Phe Thr Ser Asn Asn Ser Cys Ser 
            180                 185                 190         


Ser Pro Gly Gly Cys Arg Leu Phe Leu Ser Thr Ile Pro Val Leu Trp 
        195                 200                 205             


Thr Leu Leu Gly Ser 
    210             


<210>  4584
<211>  201
<212>  PRT
<213>  Homo Sapiens

<400>  4584

Met Arg Leu Leu Pro Leu Leu Arg Thr Val Leu Trp Ala Ala Phe Leu 
1               5                   10                  15      


Gly Ser Pro Leu Arg Gly Gly Ser Ser Leu Arg His Val Val Tyr Trp 
            20                  25                  30          


Asn Ser Ser Asn Pro Arg Leu Leu Arg Gly Asp Ala Val Val Glu Leu 
        35                  40                  45              


Gly Leu Asn Asp Tyr Leu Asp Ile Val Cys Pro His Tyr Glu Gly Pro 
    50                  55                  60                  


Gly Pro Pro Glu Gly Pro Glu Thr Phe Ala Leu Tyr Met Val Asp Trp 
65                  70                  75                  80  


Pro Gly Tyr Glu Ser Cys Gln Ala Glu Gly Pro Arg Ala Tyr Lys Arg 
                85                  90                  95      


Trp Val Cys Ser Leu Pro Phe Gly His Val Gln Phe Ser Glu Lys Ile 
            100                 105                 110         


Gln Arg Phe Thr Pro Phe Ser Leu Gly Phe Glu Phe Leu Pro Gly Glu 
        115                 120                 125             


Thr Tyr Tyr Tyr Ile Ser Val Pro Thr Pro Glu Ser Ser Gly Gln Cys 
    130                 135                 140                 


Leu Arg Leu Gln Val Ser Val Cys Cys Lys Glu Arg Lys Ser Glu Ser 
145                 150                 155                 160 


Ala His Pro Val Gly Ser Pro Gly Glu Ser Gly Thr Ser Gly Trp Arg 
                165                 170                 175     


Gly Gly Asp Thr Pro Ser Pro Leu Cys Leu Leu Leu Leu Leu Leu Leu 
            180                 185                 190         


Leu Ile Leu Arg Leu Leu Arg Ile Leu 
        195                 200     


<210>  4585
<211>  193
<212>  PRT
<213>  Homo Sapiens

<400>  4585

Met Arg Leu Leu Pro Leu Leu Arg Thr Val Leu Trp Ala Ala Phe Leu 
1               5                   10                  15      


Gly Ser Pro Leu Arg Gly Gly Ser Ser Leu Arg His Val Val Tyr Trp 
            20                  25                  30          


Asn Ser Ser Asn Pro Arg Leu Leu Arg Gly Asp Ala Val Val Glu Leu 
        35                  40                  45              


Gly Leu Asn Asp Tyr Leu Asp Ile Val Cys Pro His Tyr Glu Gly Pro 
    50                  55                  60                  


Gly Pro Pro Glu Gly Pro Glu Thr Phe Ala Leu Tyr Met Val Asp Trp 
65                  70                  75                  80  


Pro Gly Tyr Glu Ser Cys Gln Ala Glu Gly Pro Arg Ala Tyr Lys Arg 
                85                  90                  95      


Trp Val Cys Ser Leu Pro Phe Gly His Val Gln Phe Ser Glu Lys Ile 
            100                 105                 110         


Gln Arg Phe Thr Pro Phe Ser Leu Gly Phe Glu Phe Leu Pro Gly Glu 
        115                 120                 125             


Thr Tyr Tyr Tyr Ile Ser Val Pro Thr Pro Glu Ser Ser Gly Gln Cys 
    130                 135                 140                 


Leu Arg Leu Gln Val Ser Val Cys Cys Lys Glu Arg Asn Leu Pro Ser 
145                 150                 155                 160 


His Pro Lys Glu Pro Glu Ser Ser Gln Asp Pro Leu Glu Glu Glu Gly 
                165                 170                 175     


Ser Leu Leu Pro Ala Leu Gly Val Pro Ile Gln Thr Asp Lys Met Glu 
            180                 185                 190         


His 
    


<210>  4586
<211>  207
<212>  PRT
<213>  Homo Sapiens

<400>  4586

Met Arg Leu Leu Pro Leu Leu Arg Thr Val Leu Trp Ala Ala Phe Leu 
1               5                   10                  15      


Gly Ser Pro Leu Arg Gly Gly Ser Ser Leu Arg His Val Val Tyr Trp 
            20                  25                  30          


Asn Ser Ser Asn Pro Arg Leu Leu Arg Gly Asp Ala Val Val Glu Leu 
        35                  40                  45              


Gly Leu Asn Asp Tyr Leu Asp Ile Val Cys Pro His Tyr Glu Gly Pro 
    50                  55                  60                  


Gly Pro Pro Glu Gly Pro Glu Thr Phe Ala Leu Tyr Met Val Asp Trp 
65                  70                  75                  80  


Pro Gly Tyr Glu Ser Cys Gln Ala Glu Gly Pro Arg Ala Tyr Lys Arg 
                85                  90                  95      


Trp Val Cys Ser Leu Pro Phe Gly His Val Gln Phe Ser Glu Lys Ile 
            100                 105                 110         


Gln Arg Phe Thr Pro Phe Ser Leu Gly Phe Glu Phe Leu Pro Gly Glu 
        115                 120                 125             


Thr Tyr Tyr Tyr Ile Ser Val Pro Thr Pro Glu Ser Ser Gly Gln Cys 
    130                 135                 140                 


Leu Arg Leu Gln Val Ser Val Cys Cys Lys Glu Arg Arg Ala Arg Val 
145                 150                 155                 160 


Leu Pro Arg Ser Pro Gly Gly Gly Gly Ile Pro Ala Ala Cys Thr Gly 
                165                 170                 175     


Gly Ala Asn Ser Asp Arg Gln Asp Gly Ala Leu Met Gly Glu Ile Arg 
            180                 185                 190         


Gly Ser Glu Val Thr Leu Ala Gly Ala Cys Pro Leu Ile Thr Gly 
        195                 200                 205         


<210>  4587
<211>  553
<212>  PRT
<213>  Homo Sapiens

<400>  4587

Met Pro Leu Pro Trp Ser Leu Ala Leu Pro Leu Leu Leu Ser Trp Val 
1               5                   10                  15      


Ala Gly Gly Phe Gly Asn Ala Ala Ser Ala Arg His His Gly Leu Leu 
            20                  25                  30          


Ala Ser Ala Arg Gln Pro Gly Val Cys His Tyr Gly Thr Lys Leu Ala 
        35                  40                  45              


Cys Cys Tyr Gly Trp Arg Arg Asn Ser Lys Gly Val Cys Glu Ala Thr 
    50                  55                  60                  


Cys Glu Pro Gly Cys Lys Phe Gly Glu Cys Val Gly Pro Asn Lys Cys 
65                  70                  75                  80  


Arg Cys Phe Pro Gly Tyr Thr Gly Lys Thr Cys Ser Gln Asp Val Asn 
                85                  90                  95      


Glu Cys Gly Met Lys Pro Arg Pro Cys Gln His Arg Cys Val Asn Thr 
            100                 105                 110         


His Gly Ser Tyr Lys Cys Phe Cys Leu Ser Gly His Met Leu Met Pro 
        115                 120                 125             


Asp Ala Thr Cys Val Asn Ser Arg Thr Cys Ala Met Ile Asn Cys Gln 
    130                 135                 140                 


Tyr Ser Cys Glu Asp Thr Glu Glu Gly Pro Gln Cys Leu Cys Pro Ser 
145                 150                 155                 160 


Ser Gly Leu Arg Leu Ala Pro Asn Gly Arg Asp Cys Leu Asp Ile Asp 
                165                 170                 175     


Glu Cys Ala Ser Gly Lys Val Ile Cys Pro Tyr Asn Arg Arg Cys Val 
            180                 185                 190         


Asn Thr Phe Gly Ser Tyr Tyr Cys Lys Cys His Ile Gly Phe Glu Leu 
        195                 200                 205             


Gln Tyr Ile Ser Gly Arg Tyr Asp Cys Ile Asp Ile Asn Glu Cys Thr 
    210                 215                 220                 


Met Asp Ser His Thr Cys Ser His His Ala Asn Cys Phe Asn Thr Gln 
225                 230                 235                 240 


Gly Ser Phe Lys Cys Lys Cys Lys Gln Gly Tyr Lys Gly Asn Gly Leu 
                245                 250                 255     


Arg Cys Ser Ala Ile Pro Glu Asn Ser Val Lys Glu Val Leu Arg Ala 
            260                 265                 270         


Pro Gly Thr Ile Lys Asp Arg Ile Lys Lys Leu Leu Ala His Lys Asn 
        275                 280                 285             


Ser Met Lys Lys Lys Ala Lys Ile Lys Asn Val Thr Pro Glu Pro Thr 
    290                 295                 300                 


Arg Thr Pro Thr Pro Lys Val Asn Leu Gln Pro Phe Asn Tyr Glu Glu 
305                 310                 315                 320 


Ile Val Ser Arg Gly Gly Asn Ser His Gly Gly Lys Lys Gly Asn Glu 
                325                 330                 335     


Glu Lys Met Lys Glu Gly Leu Glu Asp Glu Lys Arg Glu Glu Lys Ala 
            340                 345                 350         


Leu Lys Asn Asp Ile Glu Glu Arg Ser Leu Arg Gly Asp Val Phe Phe 
        355                 360                 365             


Pro Lys Val Asn Glu Ala Gly Glu Phe Gly Leu Ile Leu Val Gln Arg 
    370                 375                 380                 


Lys Ala Leu Thr Ser Lys Leu Glu His Lys Asp Leu Asn Ile Ser Val 
385                 390                 395                 400 


Asp Cys Ser Phe Asn His Gly Ile Cys Asp Trp Lys Gln Asp Arg Glu 
                405                 410                 415     


Asp Asp Phe Asp Trp Asn Pro Ala Asp Arg Asp Asn Ala Ile Gly Phe 
            420                 425                 430         


Tyr Met Ala Val Pro Ala Leu Ala Gly His Lys Lys Asp Ile Gly Arg 
        435                 440                 445             


Leu Lys Leu Leu Leu Pro Asp Leu Gln Pro Gln Ser Asn Phe Cys Leu 
    450                 455                 460                 


Leu Phe Asp Tyr Arg Leu Ala Gly Asp Lys Val Gly Lys Leu Arg Val 
465                 470                 475                 480 


Phe Val Lys Asn Ser Asn Asn Ala Leu Ala Trp Glu Lys Thr Thr Ser 
                485                 490                 495     


Glu Asp Glu Lys Trp Lys Thr Gly Lys Ile Gln Leu Tyr Gln Gly Thr 
            500                 505                 510         


Asp Ala Thr Lys Ser Ile Ile Phe Glu Ala Glu Arg Gly Lys Gly Lys 
        515                 520                 525             


Thr Gly Glu Ile Ala Val Asp Gly Val Leu Leu Val Ser Gly Leu Cys 
    530                 535                 540                 


Pro Asp Ser Leu Leu Ser Val Asp Asp 
545                 550             


<210>  4588
<211>  554
<212>  PRT
<213>  Homo Sapiens

<400>  4588

Met Pro Leu Pro Trp Ser Leu Ala Leu Pro Leu Leu Leu Ser Trp Val 
1               5                   10                  15      


Ala Gly Gly Phe Gly Asn Ala Ala Ser Ala Arg His His Gly Leu Leu 
            20                  25                  30          


Ala Ser Ala Arg Gln Pro Gly Val Cys His Tyr Gly Thr Lys Leu Ala 
        35                  40                  45              


Cys Cys Tyr Gly Trp Arg Arg Asn Ser Lys Gly Val Cys Glu Ala Thr 
    50                  55                  60                  


Cys Glu Pro Gly Cys Lys Phe Gly Glu Cys Val Gly Pro Asn Lys Cys 
65                  70                  75                  80  


Arg Cys Phe Pro Gly Tyr Thr Gly Lys Thr Cys Ser Gln Asp Val Asn 
                85                  90                  95      


Glu Cys Gly Met Lys Pro Arg Pro Cys Gln His Arg Cys Val Asn Thr 
            100                 105                 110         


His Gly Ser Tyr Lys Cys Phe Cys Leu Ser Gly His Met Leu Met Pro 
        115                 120                 125             


Asp Ala Thr Cys Val Asn Ser Arg Thr Cys Ala Met Ile Asn Cys Gln 
    130                 135                 140                 


Tyr Ser Cys Glu Asp Thr Glu Glu Gly Pro Gln Cys Leu Cys Pro Ser 
145                 150                 155                 160 


Ser Gly Leu Arg Leu Ala Pro Asn Gly Arg Asp Cys Leu Asp Ile Asp 
                165                 170                 175     


Glu Cys Ala Ser Gly Lys Val Ile Cys Pro Tyr Asn Arg Arg Cys Val 
            180                 185                 190         


Asn Thr Phe Gly Ser Tyr Tyr Cys Lys Cys His Ile Gly Phe Glu Leu 
        195                 200                 205             


Gln Tyr Ile Ser Gly Arg Tyr Asp Cys Ile Asp Ile Asn Glu Cys Thr 
    210                 215                 220                 


Met Asp Ser His Thr Cys Ser His His Ala Asn Cys Phe Asn Thr Gln 
225                 230                 235                 240 


Gly Ser Phe Lys Cys Lys Cys Lys Gln Gly Tyr Lys Gly Asn Gly Leu 
                245                 250                 255     


Arg Cys Ser Ala Ile Pro Glu Asn Ser Val Lys Glu Val Leu Arg Ala 
            260                 265                 270         


Pro Gly Thr Ile Lys Asp Arg Ile Lys Lys Leu Leu Ala His Lys Asn 
        275                 280                 285             


Ser Met Lys Lys Lys Ala Lys Ile Lys Asn Val Thr Pro Glu Pro Thr 
    290                 295                 300                 


Arg Thr Pro Thr Pro Lys Val Asn Leu Gln Pro Phe Asn Tyr Glu Glu 
305                 310                 315                 320 


Ile Val Ser Arg Gly Gly Asn Ser His Gly Gly Lys Lys Gly Asn Glu 
                325                 330                 335     


Glu Lys Met Lys Glu Gly Leu Glu Asp Glu Lys Arg Glu Glu Lys Ala 
            340                 345                 350         


Leu Lys Asn Asp Ile Glu Glu Arg Ser Leu Arg Gly Asp Val Phe Phe 
        355                 360                 365             


Pro Lys Val Asn Glu Ala Gly Glu Phe Gly Leu Ile Leu Val Gln Arg 
    370                 375                 380                 


Lys Ala Leu Thr Ser Lys Leu Glu His Lys Ala Asp Leu Asn Ile Ser 
385                 390                 395                 400 


Val Asp Cys Ser Phe Asn His Gly Ile Cys Asp Trp Lys Gln Asp Arg 
                405                 410                 415     


Glu Asp Asp Phe Asp Trp Asn Pro Ala Asp Arg Asp Asn Ala Ile Gly 
            420                 425                 430         


Phe Tyr Met Ala Val Pro Ala Leu Ala Gly His Lys Lys Asp Ile Gly 
        435                 440                 445             


Arg Leu Lys Leu Leu Leu Pro Asp Leu Gln Pro Gln Ser Asn Phe Cys 
    450                 455                 460                 


Leu Leu Phe Asp Tyr Arg Leu Ala Gly Asp Lys Val Gly Lys Leu Arg 
465                 470                 475                 480 


Val Phe Val Lys Asn Ser Asn Asn Ala Leu Ala Trp Glu Lys Thr Thr 
                485                 490                 495     


Ser Glu Asp Glu Lys Trp Lys Thr Gly Lys Ile Gln Leu Tyr Gln Gly 
            500                 505                 510         


Thr Asp Ala Thr Lys Ser Ile Ile Phe Glu Ala Glu Arg Gly Lys Gly 
        515                 520                 525             


Lys Thr Gly Glu Ile Ala Val Asp Gly Val Leu Leu Val Ser Gly Leu 
    530                 535                 540                 


Cys Pro Asp Ser Leu Leu Ser Val Asp Asp 
545                 550                 


<210>  4589
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  4589

Met Arg Gly Ser Gln Glu Val Leu Leu Met Trp Leu Leu Val Leu Ala 
1               5                   10                  15      


Val Gly Gly Thr Glu His Ala Tyr Arg Pro Gly Arg Arg Val Cys Ala 
            20                  25                  30          


Val Arg Ala His Gly Asp Pro Val Ser Glu Ser Phe Val Gln Arg Val 
        35                  40                  45              


Tyr Gln Pro Phe Leu Thr Thr Cys Asp Gly His Arg Ala Cys Ser Thr 
    50                  55                  60                  


Tyr Arg 
65      


<210>  4590
<211>  273
<212>  PRT
<213>  Homo Sapiens

<400>  4590

Met Arg Gly Ser Gln Glu Val Leu Leu Met Trp Leu Leu Val Leu Ala 
1               5                   10                  15      


Val Gly Gly Thr Glu His Ala Tyr Arg Pro Gly Arg Arg Val Cys Ala 
            20                  25                  30          


Val Arg Ala His Gly Asp Pro Val Ser Glu Ser Phe Val Gln Arg Val 
        35                  40                  45              


Tyr Gln Pro Phe Leu Thr Thr Cys Asp Gly His Arg Ala Cys Ser Thr 
    50                  55                  60                  


Tyr Arg Thr Ile Tyr Arg Thr Ala Tyr Arg Arg Ser Pro Gly Leu Ala 
65                  70                  75                  80  


Pro Ala Arg Pro Arg Tyr Ala Cys Cys Pro Gly Trp Lys Arg Thr Ser 
                85                  90                  95      


Gly Leu Pro Gly Ala Cys Gly Ala Ala Ile Cys Gln Pro Pro Cys Arg 
            100                 105                 110         


Asn Gly Gly Ser Cys Val Gln Pro Gly Arg Cys Arg Cys Pro Ala Gly 
        115                 120                 125             


Trp Arg Gly Asp Thr Cys Gln Ser Asp Val Asp Glu Cys Ser Ala Arg 
    130                 135                 140                 


Arg Gly Gly Cys Pro Gln Arg Cys Val Asn Thr Ala Gly Ser Tyr Trp 
145                 150                 155                 160 


Cys Gln Cys Trp Glu Gly His Ser Leu Ser Ala Asp Gly Thr Leu Cys 
                165                 170                 175     


Val Pro Lys Gly Gly Pro Pro Arg Val Ala Pro Asn Pro Thr Gly Val 
            180                 185                 190         


Asp Ser Ala Met Lys Glu Glu Val Gln Arg Leu Gln Ser Arg Val Asp 
        195                 200                 205             


Leu Leu Glu Glu Lys Leu Gln Leu Val Leu Ala Pro Leu His Ser Leu 
    210                 215                 220                 


Ala Ser Gln Ala Leu Glu His Gly Leu Pro Asp Pro Gly Ser Leu Leu 
225                 230                 235                 240 


Val His Ser Phe Gln Gln Leu Gly Arg Ile Asp Ser Leu Ser Glu Gln 
                245                 250                 255     


Ile Ser Phe Leu Glu Glu Gln Leu Gly Ser Cys Ser Cys Lys Lys Asp 
            260                 265                 270         


Ser 
    


<210>  4591
<211>  273
<212>  PRT
<213>  Homo Sapiens

<400>  4591

Met Arg Gly Ser Gln Glu Val Leu Leu Met Trp Leu Leu Val Leu Ala 
1               5                   10                  15      


Val Gly Gly Thr Glu His Ala Tyr Arg Pro Gly Arg Arg Val Cys Ala 
            20                  25                  30          


Val Arg Ala His Gly Asp Pro Val Ser Glu Ser Phe Val Gln Arg Val 
        35                  40                  45              


Tyr Gln Pro Phe Leu Thr Thr Cys Asp Gly His Arg Ala Cys Ser Thr 
    50                  55                  60                  


Tyr Arg Thr Ile Tyr Arg Thr Ala Tyr Arg Arg Ser Pro Gly Leu Ala 
65                  70                  75                  80  


Pro Ala Arg Pro Arg Tyr Ala Cys Cys Pro Gly Trp Lys Arg Thr Ser 
                85                  90                  95      


Gly Leu Pro Gly Ala Cys Gly Ala Ala Ile Cys Gln Pro Pro Cys Arg 
            100                 105                 110         


Asn Gly Gly Ser Cys Val Gln Pro Gly Arg Cys Arg Cys Pro Ala Gly 
        115                 120                 125             


Trp Arg Gly Asp Thr Cys Gln Ser Asp Val Asp Glu Cys Ser Ala Arg 
    130                 135                 140                 


Arg Gly Gly Cys Pro Gln Arg Cys Val Asn Thr Ala Gly Ser Tyr Trp 
145                 150                 155                 160 


Cys Gln Cys Trp Glu Gly His Ser Leu Ser Ala Asp Gly Thr Leu Cys 
                165                 170                 175     


Val Pro Lys Gly Gly Pro Pro Arg Val Ala Pro Asn Pro Thr Gly Val 
            180                 185                 190         


Asp Ser Ala Met Lys Glu Glu Val Gln Arg Leu Gln Ser Arg Val Asp 
        195                 200                 205             


Leu Leu Glu Glu Lys Leu Gln Leu Val Leu Ala Pro Leu His Ser Leu 
    210                 215                 220                 


Ala Ser Gln Ala Leu Glu His Gly Leu Pro Asp Pro Gly Ser Leu Leu 
225                 230                 235                 240 


Val His Ser Phe Gln Gln Leu Gly Arg Ile Asp Ser Leu Ser Glu Gln 
                245                 250                 255     


Ile Ser Phe Leu Glu Glu Gln Leu Gly Ser Cys Ser Cys Lys Lys Asp 
            260                 265                 270         


Ser 
    


<210>  4592
<211>  273
<212>  PRT
<213>  Homo Sapiens

<400>  4592

Met Arg Gly Ser Gln Glu Val Leu Leu Met Trp Leu Leu Val Leu Ala 
1               5                   10                  15      


Val Gly Gly Thr Glu His Ala Tyr Arg Pro Gly Arg Arg Val Cys Ala 
            20                  25                  30          


Val Arg Ala His Gly Asp Pro Val Ser Glu Ser Phe Val Gln Arg Val 
        35                  40                  45              


Tyr Gln Pro Phe Leu Thr Thr Cys Asp Gly His Arg Ala Cys Ser Thr 
    50                  55                  60                  


Tyr Arg Thr Ile Tyr Arg Thr Ala Tyr Arg Arg Ser Pro Gly Leu Ala 
65                  70                  75                  80  


Pro Ala Arg Pro Arg Tyr Ala Cys Cys Pro Gly Trp Lys Arg Thr Ser 
                85                  90                  95      


Gly Leu Pro Gly Ala Cys Gly Ala Ala Ile Cys Gln Pro Pro Cys Arg 
            100                 105                 110         


Asn Gly Gly Ser Cys Val Gln Pro Gly Arg Cys Arg Cys Pro Ala Gly 
        115                 120                 125             


Trp Arg Gly Asp Thr Cys Gln Ser Asp Val Asp Glu Cys Ser Ala Arg 
    130                 135                 140                 


Arg Gly Gly Cys Pro Gln Arg Cys Val Asn Thr Ala Gly Ser Tyr Trp 
145                 150                 155                 160 


Cys Gln Cys Trp Glu Gly His Ser Leu Ser Ala Asp Gly Thr Leu Cys 
                165                 170                 175     


Val Pro Lys Gly Gly Pro Pro Arg Val Ala Pro Asn Pro Thr Gly Val 
            180                 185                 190         


Asp Ser Ala Met Lys Glu Glu Val Gln Arg Leu Gln Ser Arg Val Asp 
        195                 200                 205             


Leu Leu Glu Glu Lys Leu Gln Leu Val Leu Ala Pro Leu His Ser Leu 
    210                 215                 220                 


Ala Ser Gln Ala Leu Glu His Gly Leu Pro Asp Pro Gly Ser Leu Leu 
225                 230                 235                 240 


Val His Ser Phe Gln Gln Leu Gly Arg Ile Asp Ser Leu Ser Glu Gln 
                245                 250                 255     


Ile Ser Phe Leu Glu Glu Gln Leu Gly Ser Cys Ser Cys Lys Lys Asp 
            260                 265                 270         


Ser 
    


<210>  4593
<211>  273
<212>  PRT
<213>  Homo Sapiens

<400>  4593

Met Arg Gly Ser Gln Glu Val Leu Leu Met Trp Leu Leu Val Leu Ala 
1               5                   10                  15      


Val Gly Gly Thr Glu His Ala Tyr Arg Pro Gly Arg Arg Val Cys Ala 
            20                  25                  30          


Val Arg Ala His Gly Asp Pro Val Ser Glu Ser Phe Val Gln Arg Val 
        35                  40                  45              


Tyr Gln Pro Phe Leu Thr Thr Cys Asp Gly His Arg Ala Cys Ser Thr 
    50                  55                  60                  


Tyr Arg Thr Ile Tyr Arg Thr Ala Tyr Arg Arg Ser Pro Gly Leu Ala 
65                  70                  75                  80  


Pro Ala Arg Pro Arg Tyr Ala Cys Cys Pro Gly Trp Lys Arg Thr Ser 
                85                  90                  95      


Gly Leu Pro Gly Ala Cys Gly Ala Ala Ile Cys Gln Pro Pro Cys Arg 
            100                 105                 110         


Asn Gly Gly Ser Cys Val Gln Pro Gly Arg Cys Arg Cys Pro Ala Gly 
        115                 120                 125             


Trp Arg Gly Asp Thr Cys Gln Ser Asp Val Asp Glu Cys Ser Ala Arg 
    130                 135                 140                 


Arg Gly Gly Cys Pro Gln Arg Cys Val Asn Thr Ala Gly Ser Tyr Trp 
145                 150                 155                 160 


Cys Gln Cys Trp Glu Gly His Ser Leu Ser Ala Asp Gly Thr Leu Cys 
                165                 170                 175     


Val Pro Lys Gly Gly Pro Pro Arg Val Ala Pro Asn Pro Thr Gly Val 
            180                 185                 190         


Asp Ser Ala Met Lys Glu Glu Val Gln Arg Leu Gln Ser Arg Val Asp 
        195                 200                 205             


Leu Leu Glu Glu Lys Leu Gln Leu Val Leu Ala Pro Leu His Ser Leu 
    210                 215                 220                 


Ala Ser Gln Ala Leu Glu His Gly Leu Pro Asp Pro Gly Ser Leu Leu 
225                 230                 235                 240 


Val His Ser Phe Gln Gln Leu Gly Arg Ile Asp Ser Leu Ser Glu Gln 
                245                 250                 255     


Ile Ser Phe Leu Glu Glu Gln Leu Gly Ser Cys Ser Cys Lys Lys Asp 
            260                 265                 270         


Ser 
    


<210>  4594
<211>  293
<212>  PRT
<213>  Homo Sapiens

<400>  4594

Met Gly Ser Arg Ala Glu Leu Cys Thr Leu Leu Gly Gly Phe Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Ile Pro Gly Glu Gly Ala Lys Gly Gly Ser Leu Arg 
            20                  25                  30          


Glu Ser Gln Gly Val Cys Ser Lys Gln Thr Leu Val Val Pro Leu His 
        35                  40                  45              


Tyr Asn Glu Ser Tyr Ser Gln Pro Val Tyr Lys Pro Tyr Leu Thr Leu 
    50                  55                  60                  


Cys Ala Gly Arg Arg Ile Cys Ser Thr Tyr Arg Thr Met Tyr Arg Val 
65                  70                  75                  80  


Met Trp Arg Glu Val Arg Arg Glu Val Gln Gln Thr His Ala Val Cys 
                85                  90                  95      


Cys Gln Gly Trp Lys Lys Arg His Pro Gly Ala Leu Thr Cys Glu Ala 
            100                 105                 110         


Ile Cys Ala Lys Pro Cys Leu Asn Gly Gly Val Cys Val Arg Pro Asp 
        115                 120                 125             


Gln Cys Glu Cys Ala Pro Gly Trp Gly Gly Lys His Cys His Val Asp 
    130                 135                 140                 


Val Asp Glu Cys Arg Thr Ser Ile Thr Leu Cys Ser His His Cys Phe 
145                 150                 155                 160 


Asn Thr Ala Gly Ser Phe Thr Cys Gly Cys Pro His Asp Leu Val Leu 
                165                 170                 175     


Gly Val Asp Gly Arg Thr Cys Met Glu Gly Ser Pro Glu Pro Pro Thr 
            180                 185                 190         


Ser Ala Ser Ile Leu Ser Val Ala Val Arg Glu Ala Glu Lys Asp Glu 
        195                 200                 205             


Arg Ala Leu Lys Gln Glu Ile His Glu Leu Arg Gly Arg Leu Glu Arg 
    210                 215                 220                 


Leu Glu Gln Trp Ala Gly Gln Ala Gly Ala Trp Val Arg Ala Val Leu 
225                 230                 235                 240 


Pro Val Pro Pro Glu Glu Leu Gln Pro Glu Gln Val Ala Glu Leu Trp 
                245                 250                 255     


Gly Arg Gly Asp Arg Ile Glu Ser Leu Ser Asp Gln Val Leu Leu Leu 
            260                 265                 270         


Glu Glu Arg Leu Gly Ala Cys Ser Cys Glu Asp Asn Ser Leu Gly Leu 
        275                 280                 285             


Gly Val Asn His Arg 
    290             


<210>  4595
<211>  293
<212>  PRT
<213>  Homo Sapiens

<400>  4595

Met Gly Ser Arg Ala Glu Leu Cys Thr Leu Leu Gly Gly Phe Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Ile Pro Gly Glu Gly Ala Lys Gly Gly Ser Leu Arg 
            20                  25                  30          


Glu Ser Gln Gly Val Cys Ser Lys Gln Thr Leu Val Val Pro Leu His 
        35                  40                  45              


Tyr Asn Glu Ser Tyr Ser Gln Pro Val Tyr Lys Pro Tyr Leu Thr Leu 
    50                  55                  60                  


Cys Ala Gly Arg Arg Ile Cys Ser Thr Tyr Arg Thr Met Tyr Arg Val 
65                  70                  75                  80  


Met Trp Arg Glu Val Arg Arg Glu Val Gln Gln Thr His Ala Val Cys 
                85                  90                  95      


Cys Gln Gly Trp Lys Lys Arg His Pro Gly Ala Leu Thr Cys Glu Ala 
            100                 105                 110         


Ile Cys Ala Lys Pro Cys Leu Asn Gly Gly Val Cys Val Arg Pro Asp 
        115                 120                 125             


Gln Cys Glu Cys Ala Pro Gly Trp Gly Gly Lys His Cys His Val Asp 
    130                 135                 140                 


Val Asp Glu Cys Arg Thr Ser Ile Thr Leu Cys Ser His His Cys Phe 
145                 150                 155                 160 


Asn Thr Ala Gly Ser Phe Thr Cys Gly Cys Pro His Asp Leu Val Leu 
                165                 170                 175     


Gly Val Asp Gly Arg Thr Cys Met Glu Gly Ser Pro Glu Pro Pro Thr 
            180                 185                 190         


Ser Ala Ser Ile Leu Ser Val Ala Val Arg Glu Ala Glu Lys Asp Glu 
        195                 200                 205             


Arg Ala Leu Lys Gln Glu Ile His Glu Leu Arg Gly Arg Leu Glu Arg 
    210                 215                 220                 


Leu Glu Gln Trp Ala Gly Gln Ala Gly Ala Trp Val Arg Ala Val Leu 
225                 230                 235                 240 


Pro Val Pro Pro Glu Glu Leu Gln Pro Glu Gln Val Ala Glu Leu Trp 
                245                 250                 255     


Gly Arg Gly Asp Arg Ile Glu Ser Leu Ser Asp Gln Val Leu Leu Leu 
            260                 265                 270         


Glu Glu Arg Leu Gly Ala Cys Ser Cys Glu Asp Asn Ser Leu Gly Leu 
        275                 280                 285             


Gly Val Asn His Arg 
    290             


<210>  4596
<211>  258
<212>  PRT
<213>  Homo Sapiens

<400>  4596

Met Gly Ser Arg Ala Glu Leu Cys Thr Leu Leu Gly Gly Phe Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Ile Pro Gly Glu Gly Ala Lys Gly Gly Ser Leu Arg 
            20                  25                  30          


Glu Ser Gln Gly Val Cys Ser Lys Gln Thr Leu Val Val Pro Leu His 
        35                  40                  45              


Tyr Asn Glu Ser Tyr Ser Gln Pro Val Tyr Lys Pro Tyr Leu Thr Leu 
    50                  55                  60                  


Cys Ala Gly Arg Arg Ile Cys Ser Thr Tyr Arg Thr Met Tyr Arg Val 
65                  70                  75                  80  


Met Trp Arg Glu Val Arg Arg Glu Val Gln Gln Thr His Ala Val Cys 
                85                  90                  95      


Cys Gln Gly Trp Lys Lys Arg His Pro Gly Ala Leu Thr Cys Glu Ala 
            100                 105                 110         


Ile Cys Ala Lys Pro Cys Leu Asn Gly Gly Val Cys Val Arg Pro Asp 
        115                 120                 125             


Gln Cys Glu Cys Ala Pro Gly Trp Gly Gly Lys His Cys His Val Gly 
    130                 135                 140                 


Ser Phe Thr Cys Gly Cys Pro His Asp Leu Val Leu Gly Val Asp Gly 
145                 150                 155                 160 


Arg Thr Cys Met Glu Gly Ser Pro Glu Pro Pro Thr Ser Ala Ser Ile 
                165                 170                 175     


Leu Ser Val Ala Val Arg Glu Ala Glu Lys Asp Glu Arg Ala Leu Lys 
            180                 185                 190         


Gln Glu Ile His Glu Leu Arg Gly Arg Leu Glu Arg Leu Glu Gln Trp 
        195                 200                 205             


Ala Gly Gln Ala Gly Ala Trp Val Arg Ala Val Leu Pro Val Pro Pro 
    210                 215                 220                 


Glu Glu Leu Gln Pro Glu Gln Val Ala Glu Leu Trp Gly Arg Gly Asp 
225                 230                 235                 240 


Arg Ile Glu Ser Leu Ser Asp Gln Val Leu Leu Leu Glu Glu Arg Leu 
                245                 250                 255     


Gly Ala 
        


<210>  4597
<211>  1009
<212>  PRT
<213>  Homo Sapiens

<400>  4597

Met Asp Leu Ile Arg Gly Val Leu Leu Arg Leu Leu Leu Leu Ala Ser 
1               5                   10                  15      


Ser Leu Gly Pro Gly Ala Val Ser Leu Arg Ala Ala Ile Arg Lys Pro 
            20                  25                  30          


Gly Lys Val Gly Pro Pro Leu Asp Ile Lys Leu Gly Ala Leu Asn Cys 
        35                  40                  45              


Thr Ala Phe Ser Ile Gln Trp Lys Met Pro Arg His Pro Gly Ser Pro 
    50                  55                  60                  


Ile Leu Gly Tyr Thr Val Phe Tyr Ser Glu Val Gly Ala Asp Lys Ser 
65                  70                  75                  80  


Leu Gln Glu Gln Leu His Ser Val Pro Leu Ser Arg Asp Ile Pro Thr 
                85                  90                  95      


Thr Glu Glu Val Ile Gly Asp Leu Lys Pro Gly Thr Glu Tyr Arg Val 
            100                 105                 110         


Ser Ile Ala Ala Tyr Ser Gln Ala Gly Lys Gly Arg Leu Ser Ser Pro 
        115                 120                 125             


Arg His Val Thr Thr Leu Ser Gln Asp Ser Cys Leu Pro Pro Ala Ala 
    130                 135                 140                 


Pro Gln Gln Pro His Val Ile Val Val Ser Asp Ser Glu Val Ala Leu 
145                 150                 155                 160 


Ser Trp Lys Pro Gly Ala Ser Glu Gly Ser Ala Pro Ile Gln Tyr Tyr 
                165                 170                 175     


Ser Val Glu Phe Ile Arg Pro Asp Phe Asp Lys Lys Trp Thr Ser Ile 
            180                 185                 190         


His Glu Arg Ile Gln Met Asp Ser Met Val Ile Lys Gly Leu Asp Pro 
        195                 200                 205             


Asp Thr Asn Tyr Gln Phe Ala Val Arg Ala Met Asn Ser His Gly Pro 
    210                 215                 220                 


Ser Pro Arg Ser Trp Pro Ser Asp Ile Ile Arg Thr Leu Cys Pro Glu 
225                 230                 235                 240 


Glu Ala Gly Ser Gly Arg Tyr Gly Pro Arg Tyr Ile Thr Asp Met Gly 
                245                 250                 255     


Ala Gly Glu Asp Asp Glu Gly Phe Glu Asp Asp Leu Asp Leu Asp Ile 
            260                 265                 270         


Ser Phe Glu Glu Val Lys Pro Leu Pro Ala Thr Lys Gly Gly Asn Lys 
        275                 280                 285             


Lys Phe Leu Val Glu Ser Lys Lys Met Ser Ile Ser Asn Pro Lys Thr 
    290                 295                 300                 


Ile Ser Arg Leu Ile Pro Pro Thr Ser Ala Ser Leu Pro Val Thr Thr 
305                 310                 315                 320 


Val Ala Pro Gln Pro Ile Pro Ile Gln Arg Lys Gly Lys Asn Gly Val 
                325                 330                 335     


Ala Ile Met Ser Arg Leu Phe Asp Met Pro Cys Asp Glu Thr Leu Cys 
            340                 345                 350         


Ser Ala Asp Ser Phe Cys Val Asn Asp Tyr Thr Trp Gly Gly Ser Arg 
        355                 360                 365             


Cys Gln Cys Thr Leu Gly Lys Gly Gly Glu Ser Cys Ser Glu Asp Ile 
    370                 375                 380                 


Val Ile Gln Tyr Pro Gln Phe Phe Gly His Ser Tyr Val Thr Phe Glu 
385                 390                 395                 400 


Pro Leu Lys Asn Ser Tyr Gln Ala Phe Gln Ile Thr Leu Glu Phe Arg 
                405                 410                 415     


Ala Glu Ala Glu Asp Gly Leu Leu Leu Tyr Cys Gly Glu Asn Glu His 
            420                 425                 430         


Gly Arg Gly Asp Phe Met Ser Leu Ala Ile Ile Arg Arg Ser Leu Gln 
        435                 440                 445             


Phe Arg Phe Asn Cys Gly Thr Gly Val Ala Ile Ile Val Ser Glu Thr 
    450                 455                 460                 


Lys Ile Lys Leu Gly Gly Trp His Thr Val Met Leu Tyr Arg Asp Gly 
465                 470                 475                 480 


Leu Asn Gly Leu Leu Gln Leu Asn Asn Gly Thr Pro Val Thr Gly Gln 
                485                 490                 495     


Ser Gln Gly Gln Tyr Ser Lys Ile Thr Phe Arg Thr Pro Leu Tyr Leu 
            500                 505                 510         


Gly Gly Ala Pro Ser Ala Tyr Trp Leu Val Arg Ala Thr Gly Thr Asn 
        515                 520                 525             


Arg Gly Phe Gln Gly Cys Val Gln Ser Leu Ala Val Asn Gly Arg Arg 
    530                 535                 540                 


Ile Asp Met Arg Pro Trp Pro Leu Gly Lys Ala Leu Ser Gly Ala Asp 
545                 550                 555                 560 


Val Gly Glu Cys Ser Ser Gly Ile Cys Asp Glu Ala Ser Cys Ile His 
                565                 570                 575     


Gly Gly Thr Cys Thr Ala Ile Lys Ala Asp Ser Tyr Ile Cys Leu Cys 
            580                 585                 590         


Pro Leu Gly Phe Lys Gly Arg His Cys Glu Asp Ala Phe Thr Leu Thr 
        595                 600                 605             


Ile Pro Gln Phe Arg Glu Ser Leu Arg Ser Tyr Ala Ala Thr Pro Trp 
    610                 615                 620                 


Pro Leu Glu Pro Gln His Tyr Leu Ser Phe Met Glu Phe Glu Ile Thr 
625                 630                 635                 640 


Phe Arg Pro Asp Ser Gly Asp Gly Val Leu Leu Tyr Ser Tyr Asp Thr 
                645                 650                 655     


Gly Ser Lys Asp Phe Leu Ser Ile Asn Leu Ala Gly Gly His Val Glu 
            660                 665                 670         


Phe Arg Phe Asp Cys Gly Ser Gly Thr Gly Val Leu Arg Ser Glu Asp 
        675                 680                 685             


Pro Leu Thr Leu Gly Asn Trp His Glu Leu Arg Val Ser Arg Thr Ala 
    690                 695                 700                 


Lys Asn Gly Ile Leu Gln Val Asp Lys Gln Lys Ile Val Glu Gly Met 
705                 710                 715                 720 


Ala Glu Gly Gly Phe Thr Gln Ile Lys Cys Asn Thr Asp Ile Phe Ile 
                725                 730                 735     


Gly Gly Val Pro Asn Tyr Asp Asp Val Lys Lys Asn Ser Gly Val Leu 
            740                 745                 750         


Lys Pro Phe Ser Gly Ser Ile Gln Lys Ile Ile Leu Asn Asp Arg Thr 
        755                 760                 765             


Ile His Val Lys His Asp Phe Thr Ser Gly Val Asn Val Glu Asn Ala 
    770                 775                 780                 


Ala His Pro Cys Val Arg Ala Pro Cys Ala His Gly Gly Ser Cys Arg 
785                 790                 795                 800 


Pro Arg Lys Glu Gly Tyr Asp Cys Asp Cys Pro Leu Gly Phe Glu Gly 
                805                 810                 815     


Leu His Cys Gln Lys Ala Ile Ile Glu Ala Ile Glu Ile Pro Gln Phe 
            820                 825                 830         


Ile Gly Arg Ser Tyr Leu Thr Tyr Asp Asn Pro Asp Ile Leu Lys Arg 
        835                 840                 845             


Val Ser Gly Ser Arg Ser Asn Val Phe Met Arg Phe Lys Thr Thr Ala 
    850                 855                 860                 


Lys Asp Gly Leu Leu Leu Trp Arg Gly Asp Ser Pro Met Arg Pro Asn 
865                 870                 875                 880 


Ser Asp Phe Ile Ser Leu Gly Leu Arg Asp Gly Ala Leu Val Phe Ser 
                885                 890                 895     


Tyr Asn Leu Gly Ser Gly Val Ala Ser Ile Met Val Asn Gly Ser Phe 
            900                 905                 910         


Asn Asp Gly Arg Trp His Arg Val Lys Ala Val Arg Asp Gly Gln Ser 
        915                 920                 925             


Gly Lys Ile Thr Val Asp Asp Tyr Gly Ala Arg Thr Gly Lys Ser Pro 
    930                 935                 940                 


Gly Met Met Arg Gln Leu Asn Ile Asn Gly Ala Leu Tyr Val Gly Gly 
945                 950                 955                 960 


Met Lys Glu Ile Ala Leu His Thr Asn Arg Gln Tyr Met Arg Gly Leu 
                965                 970                 975     


Val Gly Cys Ile Ser His Phe Thr Leu Ser Thr Asp Tyr His Ile Ser 
            980                 985                 990         


Leu Val Glu Asp Ala Val Asp Gly  Lys Asn Ile Asn Thr  Cys Gly Ala 
        995                 1000                 1005             


Lys 
    


<210>  4598
<211>  1017
<212>  PRT
<213>  Homo Sapiens

<400>  4598

Met Asp Leu Ile Arg Gly Val Leu Leu Arg Leu Leu Leu Leu Ala Ser 
1               5                   10                  15      


Ser Leu Gly Pro Gly Ala Val Ser Leu Arg Ala Ala Ile Arg Lys Pro 
            20                  25                  30          


Gly Lys Val Gly Pro Pro Leu Asp Ile Lys Leu Gly Ala Leu Asn Cys 
        35                  40                  45              


Thr Ala Phe Ser Ile Gln Trp Lys Met Pro Arg His Pro Gly Ser Pro 
    50                  55                  60                  


Ile Leu Gly Tyr Thr Val Phe Tyr Ser Glu Val Gly Ala Asp Lys Ser 
65                  70                  75                  80  


Leu Gln Glu Gln Leu His Ser Val Pro Leu Ser Arg Asp Ile Pro Thr 
                85                  90                  95      


Thr Glu Glu Val Ile Gly Asp Leu Lys Pro Gly Thr Glu Tyr Arg Val 
            100                 105                 110         


Ser Ile Ala Ala Tyr Ser Gln Ala Gly Lys Gly Arg Leu Ser Ser Pro 
        115                 120                 125             


Arg His Val Thr Thr Leu Ser Gln Asp Ser Cys Leu Pro Pro Ala Ala 
    130                 135                 140                 


Pro Gln Gln Pro His Val Ile Val Val Ser Asp Ser Glu Val Ala Leu 
145                 150                 155                 160 


Ser Trp Lys Pro Gly Ala Ser Glu Gly Ser Ala Pro Ile Gln Tyr Tyr 
                165                 170                 175     


Ser Val Glu Phe Ile Arg Pro Asp Phe Asp Lys Lys Trp Thr Ser Ile 
            180                 185                 190         


His Glu Arg Ile Gln Met Asp Ser Met Val Ile Lys Gly Leu Asp Pro 
        195                 200                 205             


Asp Thr Asn Tyr Gln Phe Ala Val Arg Ala Met Asn Ser His Gly Pro 
    210                 215                 220                 


Ser Pro Arg Ser Trp Pro Ser Asp Ile Ile Arg Thr Leu Cys Pro Glu 
225                 230                 235                 240 


Glu Ala Gly Ser Gly Arg Tyr Gly Pro Arg Tyr Ile Thr Asp Met Gly 
                245                 250                 255     


Ala Gly Glu Asp Asp Glu Gly Phe Glu Asp Asp Leu Asp Leu Asp Ile 
            260                 265                 270         


Ser Phe Glu Glu Val Lys Pro Leu Pro Ala Thr Lys Gly Gly Asn Lys 
        275                 280                 285             


Lys Phe Leu Val Glu Ser Lys Lys Met Ser Ile Ser Asn Pro Lys Thr 
    290                 295                 300                 


Ile Ser Arg Leu Ile Pro Pro Thr Ser Ala Ser Leu Pro Val Thr Thr 
305                 310                 315                 320 


Val Ala Pro Gln Pro Ile Pro Ile Gln Arg Lys Gly Lys Asn Gly Val 
                325                 330                 335     


Ala Ile Met Ser Arg Leu Phe Asp Met Pro Cys Asp Glu Thr Leu Cys 
            340                 345                 350         


Ser Ala Asp Ser Phe Cys Val Asn Asp Tyr Thr Trp Gly Gly Ser Arg 
        355                 360                 365             


Cys Gln Cys Thr Leu Gly Lys Gly Gly Glu Ser Cys Ser Glu Asp Ile 
    370                 375                 380                 


Val Ile Gln Tyr Pro Gln Phe Phe Gly His Ser Tyr Val Thr Phe Glu 
385                 390                 395                 400 


Pro Leu Lys Asn Ser Tyr Gln Ala Phe Gln Ile Thr Leu Glu Phe Arg 
                405                 410                 415     


Ala Glu Ala Glu Asp Gly Leu Leu Leu Tyr Cys Gly Glu Asn Glu His 
            420                 425                 430         


Gly Arg Gly Asp Phe Met Ser Leu Ala Ile Ile Arg Arg Ser Leu Gln 
        435                 440                 445             


Phe Arg Phe Asn Cys Gly Thr Gly Val Ala Ile Ile Val Ser Glu Thr 
    450                 455                 460                 


Lys Ile Lys Leu Gly Gly Trp His Thr Val Met Leu Tyr Arg Asp Gly 
465                 470                 475                 480 


Leu Asn Gly Leu Leu Gln Leu Asn Asn Gly Thr Pro Val Thr Gly Gln 
                485                 490                 495     


Ser Gln Gly Gln Tyr Ser Lys Ile Thr Phe Arg Thr Pro Leu Tyr Leu 
            500                 505                 510         


Gly Gly Ala Pro Ser Ala Tyr Trp Leu Val Arg Ala Thr Gly Thr Asn 
        515                 520                 525             


Arg Gly Phe Gln Gly Cys Val Gln Ser Leu Ala Val Asn Gly Arg Arg 
    530                 535                 540                 


Ile Asp Met Arg Pro Trp Pro Leu Gly Lys Ala Leu Ser Gly Ala Asp 
545                 550                 555                 560 


Val Gly Glu Cys Ser Ser Gly Ile Cys Asp Glu Ala Ser Cys Ile His 
                565                 570                 575     


Gly Gly Thr Cys Thr Ala Ile Lys Ala Asp Ser Tyr Ile Cys Leu Cys 
            580                 585                 590         


Pro Leu Gly Phe Lys Gly Arg His Cys Glu Asp Ala Phe Thr Leu Thr 
        595                 600                 605             


Ile Pro Gln Phe Arg Glu Ser Leu Arg Ser Tyr Ala Ala Thr Pro Trp 
    610                 615                 620                 


Pro Leu Glu Pro Gln His Tyr Leu Ser Phe Met Glu Phe Glu Ile Thr 
625                 630                 635                 640 


Phe Arg Pro Asp Ser Gly Asp Gly Val Leu Leu Tyr Ser Tyr Asp Thr 
                645                 650                 655     


Gly Ser Lys Asp Phe Leu Ser Ile Asn Leu Ala Gly Gly His Val Glu 
            660                 665                 670         


Phe Arg Phe Asp Cys Gly Ser Gly Thr Gly Val Leu Arg Ser Glu Asp 
        675                 680                 685             


Pro Leu Thr Leu Gly Asn Trp His Glu Leu Arg Val Ser Arg Thr Ala 
    690                 695                 700                 


Lys Asn Gly Ile Leu Gln Val Asp Lys Gln Lys Ile Val Glu Gly Met 
705                 710                 715                 720 


Ala Glu Gly Gly Phe Thr Gln Ile Lys Cys Asn Thr Asp Ile Phe Ile 
                725                 730                 735     


Gly Gly Val Pro Asn Tyr Asp Asp Val Lys Lys Asn Ser Gly Val Leu 
            740                 745                 750         


Lys Pro Phe Ser Gly Ser Ile Gln Lys Ile Ile Leu Asn Asp Arg Thr 
        755                 760                 765             


Ile His Val Lys His Asp Phe Thr Ser Gly Val Asn Val Glu Asn Ala 
    770                 775                 780                 


Ala His Pro Cys Val Arg Ala Pro Cys Ala His Gly Gly Ser Cys Arg 
785                 790                 795                 800 


Pro Arg Lys Glu Gly Tyr Asp Cys Asp Cys Pro Leu Gly Phe Glu Gly 
                805                 810                 815     


Leu His Cys Gln Lys Glu Cys Gly Asn Tyr Cys Leu Asn Thr Ile Ile 
            820                 825                 830         


Glu Ala Ile Glu Ile Pro Gln Phe Ile Gly Arg Ser Tyr Leu Thr Tyr 
        835                 840                 845             


Asp Asn Pro Asp Ile Leu Lys Arg Val Ser Gly Ser Arg Ser Asn Val 
    850                 855                 860                 


Phe Met Arg Phe Lys Thr Thr Ala Lys Asp Gly Leu Leu Leu Trp Arg 
865                 870                 875                 880 


Gly Asp Ser Pro Met Arg Pro Asn Ser Asp Phe Ile Ser Leu Gly Leu 
                885                 890                 895     


Arg Asp Gly Ala Leu Val Phe Ser Tyr Asn Leu Gly Ser Gly Val Ala 
            900                 905                 910         


Ser Ile Met Val Asn Gly Ser Phe Asn Asp Gly Arg Trp His Arg Val 
        915                 920                 925             


Lys Ala Val Arg Asp Gly Gln Ser Gly Lys Ile Thr Val Asp Asp Tyr 
    930                 935                 940                 


Gly Ala Arg Thr Gly Lys Ser Pro Gly Met Met Arg Gln Leu Asn Ile 
945                 950                 955                 960 


Asn Gly Ala Leu Tyr Val Gly Gly Met Lys Glu Ile Ala Leu His Thr 
                965                 970                 975     


Asn Arg Gln Tyr Met Arg Gly Leu Val Gly Cys Ile Ser His Phe Thr 
            980                 985                 990         


Leu Ser Thr Asp Tyr His Ile Ser  Leu Val Glu Asp Ala  Val Asp Gly 
        995                 1000                 1005             


Lys Asn  Ile Asn Thr Cys Gly  Ala Lys 
    1010                 1015         


<210>  4599
<211>  47
<212>  PRT
<213>  Homo Sapiens

<400>  4599

Met Asp Leu Ile Arg Gly Val Leu Leu Arg Leu Leu Leu Leu Ala Ser 
1               5                   10                  15      


Ser Leu Gly Pro Gly Ala Val Ser Leu Arg Ala Ala Ile Arg Lys Pro 
            20                  25                  30          


Gly Arg Cys Trp Arg Met Thr Val Thr Lys Thr Trp Thr Glu Pro 
        35                  40                  45          


<210>  4600
<211>  375
<212>  PRT
<213>  Homo Sapiens

<400>  4600

Met Glu Phe Glu Ile Thr Phe Arg Pro Asp Ser Gly Asp Gly Val Leu 
1               5                   10                  15      


Leu Tyr Ser Tyr Asp Thr Gly Ser Lys Asp Phe Leu Ser Ile Asn Leu 
            20                  25                  30          


Ala Gly Gly His Val Glu Phe Arg Phe Asp Cys Gly Ser Gly Thr Gly 
        35                  40                  45              


Val Leu Arg Ser Glu Asp Pro Leu Thr Leu Gly Asn Trp His Glu Leu 
    50                  55                  60                  


Arg Val Ser Arg Thr Ala Lys Asn Gly Ile Leu Gln Val Asp Lys Gln 
65                  70                  75                  80  


Lys Ile Val Glu Gly Met Ala Glu Gly Gly Phe Thr Gln Ile Lys Cys 
                85                  90                  95      


Asn Thr Asp Ile Phe Ile Gly Gly Val Pro Asn Tyr Asp Asp Val Lys 
            100                 105                 110         


Lys Asn Ser Gly Val Leu Lys Pro Phe Ser Gly Ser Ile Gln Lys Ile 
        115                 120                 125             


Ile Leu Asn Asp Arg Thr Ile His Val Lys His Asp Phe Thr Ser Gly 
    130                 135                 140                 


Val Asn Val Glu Asn Ala Ala His Pro Cys Val Arg Ala Pro Cys Ala 
145                 150                 155                 160 


His Gly Gly Ser Cys Arg Pro Arg Lys Glu Gly Tyr Asp Cys Asp Cys 
                165                 170                 175     


Pro Leu Gly Phe Glu Gly Leu His Cys Gln Lys Ala Ile Ile Glu Ala 
            180                 185                 190         


Ile Glu Ile Pro Gln Phe Ile Gly Arg Ser Tyr Leu Thr Tyr Asp Asn 
        195                 200                 205             


Pro Asp Ile Leu Lys Arg Val Ser Gly Ser Arg Ser Asn Val Phe Met 
    210                 215                 220                 


Arg Phe Lys Thr Thr Ala Lys Asp Gly Leu Leu Leu Trp Arg Gly Asp 
225                 230                 235                 240 


Ser Pro Met Arg Pro Asn Ser Asp Phe Ile Ser Leu Gly Leu Arg Asp 
                245                 250                 255     


Gly Ala Leu Val Phe Ser Tyr Asn Leu Gly Ser Gly Val Ala Ser Ile 
            260                 265                 270         


Met Val Asn Gly Ser Phe Asn Asp Gly Arg Trp His Arg Val Lys Ala 
        275                 280                 285             


Val Arg Asp Gly Gln Ser Gly Lys Ile Thr Val Asp Asp Tyr Gly Ala 
    290                 295                 300                 


Arg Thr Gly Lys Ser Pro Gly Met Met Arg Gln Leu Asn Ile Asn Gly 
305                 310                 315                 320 


Ala Leu Tyr Val Gly Gly Met Lys Glu Ile Ala Leu His Thr Asn Arg 
                325                 330                 335     


Gln Tyr Met Arg Gly Leu Val Gly Cys Ile Ser His Phe Thr Leu Ser 
            340                 345                 350         


Thr Asp Tyr His Ile Ser Leu Val Glu Asp Ala Val Asp Gly Lys Asn 
        355                 360                 365             


Ile Asn Thr Cys Gly Ala Lys 
    370                 375 


<210>  4601
<211>  775
<212>  PRT
<213>  Homo Sapiens

<400>  4601

Met His Pro Gly Pro Glu Glu Ala Gly Ser Gly Arg Tyr Gly Pro Arg 
1               5                   10                  15      


Tyr Ile Thr Asp Met Gly Ala Gly Glu Asp Asp Glu Gly Phe Glu Asp 
            20                  25                  30          


Asp Leu Asp Leu Asp Ile Ser Phe Glu Glu Val Lys Pro Leu Pro Ala 
        35                  40                  45              


Thr Lys Gly Gly Asn Lys Lys Phe Leu Val Glu Ser Lys Lys Met Ser 
    50                  55                  60                  


Ile Ser Asn Pro Lys Thr Ile Ser Arg Leu Ile Pro Pro Thr Ser Ala 
65                  70                  75                  80  


Ser Leu Pro Val Thr Thr Val Ala Pro Gln Pro Ile Pro Ile Gln Arg 
                85                  90                  95      


Lys Gly Lys Asn Gly Val Ala Ile Met Ser Arg Leu Phe Asp Met Pro 
            100                 105                 110         


Cys Asp Glu Thr Leu Cys Ser Ala Asp Ser Phe Cys Val Asn Asp Tyr 
        115                 120                 125             


Thr Trp Gly Gly Ser Arg Cys Gln Cys Thr Leu Gly Lys Gly Gly Glu 
    130                 135                 140                 


Ser Cys Ser Glu Asp Ile Val Ile Gln Tyr Pro Gln Phe Phe Gly His 
145                 150                 155                 160 


Ser Tyr Val Thr Phe Glu Pro Leu Lys Asn Ser Tyr Gln Ala Phe Gln 
                165                 170                 175     


Ile Thr Leu Glu Phe Arg Ala Glu Ala Glu Asp Gly Leu Leu Leu Tyr 
            180                 185                 190         


Cys Gly Glu Asn Glu His Gly Arg Gly Asp Phe Met Ser Leu Ala Ile 
        195                 200                 205             


Ile Arg Arg Ser Leu Gln Phe Arg Phe Asn Cys Gly Thr Gly Val Ala 
    210                 215                 220                 


Ile Ile Val Ser Glu Thr Lys Ile Lys Leu Gly Gly Trp His Thr Val 
225                 230                 235                 240 


Met Leu Tyr Arg Asp Gly Leu Asn Gly Leu Leu Gln Leu Asn Asn Gly 
                245                 250                 255     


Thr Pro Val Thr Gly Gln Ser Gln Gly Gln Tyr Ser Lys Ile Thr Phe 
            260                 265                 270         


Arg Thr Pro Leu Tyr Leu Gly Gly Ala Pro Ser Ala Tyr Trp Leu Val 
        275                 280                 285             


Arg Ala Thr Gly Thr Asn Arg Gly Phe Gln Gly Cys Val Gln Ser Leu 
    290                 295                 300                 


Ala Val Asn Gly Arg Arg Ile Asp Met Arg Pro Trp Pro Leu Gly Lys 
305                 310                 315                 320 


Ala Leu Ser Gly Ala Asp Val Gly Glu Cys Ser Ser Gly Ile Cys Asp 
                325                 330                 335     


Glu Ala Ser Cys Ile His Gly Gly Thr Cys Thr Ala Ile Lys Ala Asp 
            340                 345                 350         


Ser Tyr Ile Cys Leu Cys Pro Leu Gly Phe Lys Gly Arg His Cys Glu 
        355                 360                 365             


Asp Ala Phe Thr Leu Thr Ile Pro Gln Phe Arg Glu Ser Leu Arg Ser 
    370                 375                 380                 


Tyr Ala Ala Thr Pro Trp Pro Leu Glu Pro Gln His Tyr Leu Ser Phe 
385                 390                 395                 400 


Met Glu Phe Glu Ile Thr Phe Arg Pro Asp Ser Gly Asp Gly Val Leu 
                405                 410                 415     


Leu Tyr Ser Tyr Asp Thr Gly Ser Lys Asp Phe Leu Ser Ile Asn Leu 
            420                 425                 430         


Ala Gly Gly His Val Glu Phe Arg Phe Asp Cys Gly Ser Gly Thr Gly 
        435                 440                 445             


Val Leu Arg Ser Glu Asp Pro Leu Thr Leu Gly Asn Trp His Glu Leu 
    450                 455                 460                 


Arg Val Ser Arg Thr Ala Lys Asn Gly Ile Leu Gln Val Asp Lys Gln 
465                 470                 475                 480 


Lys Ile Val Glu Gly Met Ala Glu Gly Gly Phe Thr Gln Ile Lys Cys 
                485                 490                 495     


Asn Thr Asp Ile Phe Ile Gly Gly Val Pro Asn Tyr Asp Asp Val Lys 
            500                 505                 510         


Lys Asn Ser Gly Val Leu Lys Pro Phe Ser Gly Ser Ile Gln Lys Ile 
        515                 520                 525             


Ile Leu Asn Asp Arg Thr Ile His Val Lys His Asp Phe Thr Ser Gly 
    530                 535                 540                 


Val Asn Val Glu Asn Ala Ala His Pro Cys Val Arg Ala Pro Cys Ala 
545                 550                 555                 560 


His Gly Gly Ser Cys Arg Pro Arg Lys Glu Gly Tyr Asp Cys Asp Cys 
                565                 570                 575     


Pro Leu Gly Phe Glu Gly Leu His Cys Gln Lys Ala Ile Ile Glu Ala 
            580                 585                 590         


Ile Glu Ile Pro Gln Phe Ile Gly Arg Ser Tyr Leu Thr Tyr Asp Asn 
        595                 600                 605             


Pro Asp Ile Leu Lys Arg Val Ser Gly Ser Arg Ser Asn Val Phe Met 
    610                 615                 620                 


Arg Phe Lys Thr Thr Ala Lys Asp Gly Leu Leu Leu Trp Arg Gly Asp 
625                 630                 635                 640 


Ser Pro Met Arg Pro Asn Ser Asp Phe Ile Ser Leu Gly Leu Arg Asp 
                645                 650                 655     


Gly Ala Leu Val Phe Ser Tyr Asn Leu Gly Ser Gly Val Ala Ser Ile 
            660                 665                 670         


Met Val Asn Gly Ser Phe Asn Asp Gly Arg Trp His Arg Val Lys Ala 
        675                 680                 685             


Val Arg Asp Gly Gln Ser Gly Lys Ile Thr Val Asp Asp Tyr Gly Ala 
    690                 695                 700                 


Arg Thr Gly Lys Ser Pro Gly Met Met Arg Gln Leu Asn Ile Asn Gly 
705                 710                 715                 720 


Ala Leu Tyr Val Gly Gly Met Lys Glu Ile Ala Leu His Thr Asn Arg 
                725                 730                 735     


Gln Tyr Met Arg Gly Leu Val Gly Cys Ile Ser His Phe Thr Leu Ser 
            740                 745                 750         


Thr Asp Tyr His Ile Ser Leu Val Glu Asp Ala Val Asp Gly Lys Asn 
        755                 760                 765             


Ile Asn Thr Cys Gly Ala Lys 
    770                 775 


<210>  4602
<211>  112
<212>  PRT
<213>  Homo Sapiens

<400>  4602

Met Arg Phe Lys Thr Thr Ala Lys Asp Gly Leu Leu Leu Trp Arg Gly 
1               5                   10                  15      


Asp Ser Pro Met Arg Pro Asn Ser Asp Phe Ile Ser Leu Gly Leu Arg 
            20                  25                  30          


Asp Gly Ala Leu Val Phe Ser Tyr Asn Leu Gly Ser Gly Val Ala Ser 
        35                  40                  45              


Ile Met Val Asn Gly Ser Phe Asn Asp Gly Arg Trp His Arg Val Lys 
    50                  55                  60                  


Ala Val Arg Asp Gly Gln Ser Gly Lys Ile Thr Val Asp Asp Tyr Gly 
65                  70                  75                  80  


Ala Arg Thr Gly Lys Ser Pro Gly Met Met Arg Gln Leu Asn Ile Asn 
                85                  90                  95      


Gly Ala Leu Tyr Val Gly Gly Met Lys Glu Ile Ala Leu His Thr Asn 
            100                 105                 110         


<210>  4603
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  4603

Met Arg Phe Lys Thr Thr Ala Lys Asp Gly Leu Leu Leu Trp Arg Gly 
1               5                   10                  15      


Asp Ser Pro Met Arg Pro Asn Ser Asp Phe Ile Ser Leu Gly Leu Arg 
            20                  25                  30          


Asp Gly Ala Leu Val Phe Ser Tyr Asn Leu Gly Ser Gly Val Ala Ser 
        35                  40                  45              


Ile Met Val Asn Gly Ser Phe Asn Asp Gly Arg Trp His Arg Val Lys 
    50                  55                  60                  


Ala Val Arg Asp Gly Gln Ser Gly Lys Ile Thr Val Asp Asp Tyr Gly 
65                  70                  75                  80  


Ala Arg Thr Gly Lys Ser Pro Gly Met Met Arg Gln Leu Asn Ile Asn 
                85                  90                  95      


Gly Ala Leu Tyr Val Gly Gly Met Lys Glu Ile Ala Leu His Thr Asn 
            100                 105                 110         


Arg Gln Tyr Met Arg Gly Leu Val Gly Cys Ile Ser His Phe Thr Leu 
        115                 120                 125             


Ser Thr Asp Tyr His Ile Ser Leu Val Glu Asp Ala Val Asp Gly Lys 
    130                 135                 140                 


Asn Ile Asn Thr Cys Gly Ala Lys 
145                 150         


<210>  4604
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  4604

Met Arg Phe Lys Thr Thr Ala Lys Asp Gly Leu Leu Leu Trp Arg Gly 
1               5                   10                  15      


Asp Ser Pro Met Arg Pro Asn Ser Asp Phe Ile Ser Leu Gly Leu Arg 
            20                  25                  30          


Asp Gly Ala Leu Val Phe Ser Tyr Asn Leu Gly Ser Gly Val Ala Ser 
        35                  40                  45              


Ile Met Val Asn Gly Ser Phe Asn Asp Gly Arg Trp His Arg Val Lys 
    50                  55                  60                  


Ala Val Arg Asp Gly Gln Ser Gly Lys Ile Thr Val Asp Asp Tyr Gly 
65                  70                  75                  80  


Ala Arg Thr Gly Lys Ser Pro Gly Met Met Arg Gln Leu Asn Ile Asn 
                85                  90                  95      


Gly Ala Leu Tyr Val Gly Gly Met Lys Glu Ile Ala Leu His Thr Asn 
            100                 105                 110         


Arg Gln Tyr Met Arg Gly Leu Val Gly Cys Ile Ser His Phe Thr Leu 
        115                 120                 125             


Ser Thr Asp Tyr His Ile Ser Leu Val Glu Asp Ala Val Asp Gly Lys 
    130                 135                 140                 


Asn Ile Asn Thr Cys Gly Ala Lys 
145                 150         


<210>  4605
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  4605

Met Arg Phe Lys Thr Thr Ala Lys Asp Gly Leu Leu Leu Trp Arg Gly 
1               5                   10                  15      


Asp Ser Pro Met Arg Pro Asn Ser Asp Phe Ile Ser Leu Gly Leu Arg 
            20                  25                  30          


Asp Gly Ala Leu Val Phe Ser Tyr Asn Leu Gly Ser Gly Val Ala Ser 
        35                  40                  45              


Ile Met Val Asn Gly Ser Phe Asn Asp Gly Arg Trp His Arg Val Lys 
    50                  55                  60                  


Ala Val Arg Asp Gly Gln Ser Gly Lys Ile Thr Val Asp Asp Tyr Gly 
65                  70                  75                  80  


Ala Arg Thr Gly Lys Ser Pro Gly Met Met Arg Gln Leu Asn Ile Asn 
                85                  90                  95      


Gly Ala Leu Tyr Val Gly Gly Met Lys Glu Ile Ala Leu His Thr Asn 
            100                 105                 110         


Arg Gln Tyr Met Arg Gly Leu Val Gly Cys Ile Ser His Phe Thr Leu 
        115                 120                 125             


Ser Thr Asp Tyr His Ile Ser Leu Val Glu Asp Ala Val Asp Gly Lys 
    130                 135                 140                 


Asn Ile Asn Thr Cys Gly Ala Lys 
145                 150         


<210>  4606
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  4606

Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn Leu Glu Ile Thr Tyr 
1               5                   10                  15      


Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys Thr Ile Gln Glu Val 
            20                  25                  30          


Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val Glu Arg Ile Pro Leu 
        35                  40                  45              


Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr Tyr Glu Asn Ser Tyr 
    50                  55                  60                  


Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn Lys Thr Gly Leu Lys 
65                  70                  75                  80  


Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu His Gly Ala Val Arg 
                85                  90                  95      


Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu Ser Ile Gln Trp Arg 
            100                 105                 110         


Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met Ser Met Asp Phe Gln 
        115                 120                 125             


<210>  4607
<211>  1210
<212>  PRT
<213>  Homo Sapiens

<400>  4607

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210>  4608
<211>  628
<212>  PRT
<213>  Homo Sapiens

<400>  4608

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Ser 
625             


<210>  4609
<211>  705
<212>  PRT
<213>  Homo Sapiens

<400>  4609

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Pro Gly Asn Glu Ser Leu Lys Ala Met Leu Phe Cys Leu 
625                 630                 635                 640 


Phe Lys Leu Ser Ser Cys Asn Gln Ser Asn Asp Gly Ser Val Ser His 
                645                 650                 655     


Gln Ser Gly Ser Pro Ala Ala Gln Glu Ser Cys Leu Gly Trp Ile Pro 
            660                 665                 670         


Ser Leu Leu Pro Ser Glu Phe Gln Leu Gly Trp Gly Gly Cys Ser His 
        675                 680                 685             


Leu His Ala Trp Pro Ser Ala Ser Val Ile Ile Thr Ala Ser Ser Cys 
    690                 695                 700                 


His 
705 


<210>  4610
<211>  405
<212>  PRT
<213>  Homo Sapiens

<400>  4610

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Leu Ser 
                405 


<210>  4611
<211>  1091
<212>  PRT
<213>  Homo Sapiens

<400>  4611

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Gly Gln Lys 
    130                 135                 140                 


Cys Asp Pro Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu 
145                 150                 155                 160 


Asn Cys Gln Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly 
                165                 170                 175     


Arg Cys Arg Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala 
            180                 185                 190         


Ala Gly Cys Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys 
        195                 200                 205             


Phe Arg Asp Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu 
    210                 215                 220                 


Tyr Asn Pro Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr 
225                 230                 235                 240 


Ser Phe Gly Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val 
                245                 250                 255     


Thr Asp His Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu 
            260                 265                 270         


Met Glu Glu Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys 
        275                 280                 285             


Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
    290                 295                 300                 


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
305                 310                 315                 320 


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
                325                 330                 335     


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
            340                 345                 350         


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
        355                 360                 365             


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
    370                 375                 380                 


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
385                 390                 395                 400 


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
                405                 410                 415     


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
            420                 425                 430         


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
        435                 440                 445             


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
    450                 455                 460                 


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
465                 470                 475                 480 


Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu 
                485                 490                 495     


Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln 
            500                 505                 510         


Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly 
        515                 520                 525             


Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro 
    530                 535                 540                 


His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr 
545                 550                 555                 560 


Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His 
                565                 570                 575     


Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro 
            580                 585                 590         


Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala 
        595                 600                 605             


Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg 
    610                 615                 620                 


Arg Arg His Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu 
625                 630                 635                 640 


Arg Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln 
                645                 650                 655     


Ala Leu Leu Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val 
            660                 665                 670         


Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro 
        675                 680                 685             


Glu Gly Glu Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu 
    690                 695                 700                 


Ala Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val 
705                 710                 715                 720 


Met Ala Ser Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys 
                725                 730                 735     


Leu Thr Ser Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys 
            740                 745                 750         


Leu Leu Asp Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr 
        755                 760                 765             


Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu 
    770                 775                 780                 


Asp Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val 
785                 790                 795                 800 


Lys Thr Pro Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu 
                805                 810                 815     


Leu Gly Ala Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro 
            820                 825                 830         


Ile Lys Trp Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His 
        835                 840                 845             


Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr 
    850                 855                 860                 


Phe Gly Ser Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser 
865                 870                 875                 880 


Ile Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile 
                885                 890                 895     


Asp Val Tyr Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser 
            900                 905                 910         


Arg Pro Lys Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg 
        915                 920                 925             


Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu 
    930                 935                 940                 


Pro Ser Pro Thr Asp Ser Asn Phe Tyr Arg Ala Leu Met Asp Glu Glu 
945                 950                 955                 960 


Asp Met Asp Asp Val Val Asp Ala Asp Glu Tyr Leu Ile Pro Gln Gln 
                965                 970                 975     


Gly Phe Phe Ser Ser Pro Ser Thr Ser Arg Thr Pro Leu Leu Ser Ser 
            980                 985                 990         


Leu Ser Ala Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
        995                 1000                 1005             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1010                 1015                 1020             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1025                 1030                 1035             


Asp Thr  Phe Leu Pro Val Pro  Gly Glu Trp Leu Val  Trp Lys Gln 
    1040                 1045                 1050             


Ser Cys  Ser Ser Thr Ser Ser  Thr His Ser Ala Ala  Ala Ser Leu 
    1055                 1060                 1065             


Gln Cys  Pro Ser Gln Val Leu  Pro Pro Ala Ser Pro  Glu Gly Glu 
    1070                 1075                 1080             


Thr Val  Ala Asp Leu Gln Thr  Gln 
    1085                 1090     


<210>  4612
<211>  1165
<212>  PRT
<213>  Homo Sapiens

<400>  4612

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Gly Gln Lys 
    130                 135                 140                 


Cys Asp Pro Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu 
145                 150                 155                 160 


Asn Cys Gln Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly 
                165                 170                 175     


Arg Cys Arg Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala 
            180                 185                 190         


Ala Gly Cys Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys 
        195                 200                 205             


Phe Arg Asp Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu 
    210                 215                 220                 


Tyr Asn Pro Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr 
225                 230                 235                 240 


Ser Phe Gly Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val 
                245                 250                 255     


Thr Asp His Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu 
            260                 265                 270         


Met Glu Glu Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys 
        275                 280                 285             


Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
    290                 295                 300                 


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
305                 310                 315                 320 


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
                325                 330                 335     


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
            340                 345                 350         


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
        355                 360                 365             


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
    370                 375                 380                 


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
385                 390                 395                 400 


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
                405                 410                 415     


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
            420                 425                 430         


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
        435                 440                 445             


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
    450                 455                 460                 


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
465                 470                 475                 480 


Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu 
                485                 490                 495     


Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln 
            500                 505                 510         


Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly 
        515                 520                 525             


Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro 
    530                 535                 540                 


His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr 
545                 550                 555                 560 


Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His 
                565                 570                 575     


Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro 
            580                 585                 590         


Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala 
        595                 600                 605             


Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg 
    610                 615                 620                 


Arg Arg His Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu 
625                 630                 635                 640 


Arg Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln 
                645                 650                 655     


Ala Leu Leu Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val 
            660                 665                 670         


Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro 
        675                 680                 685             


Glu Gly Glu Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu 
    690                 695                 700                 


Ala Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val 
705                 710                 715                 720 


Met Ala Ser Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys 
                725                 730                 735     


Leu Thr Ser Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys 
            740                 745                 750         


Leu Leu Asp Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr 
        755                 760                 765             


Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu 
    770                 775                 780                 


Asp Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val 
785                 790                 795                 800 


Lys Thr Pro Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu 
                805                 810                 815     


Leu Gly Ala Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro 
            820                 825                 830         


Ile Lys Trp Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His 
        835                 840                 845             


Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr 
    850                 855                 860                 


Phe Gly Ser Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser 
865                 870                 875                 880 


Ile Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile 
                885                 890                 895     


Asp Val Tyr Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser 
            900                 905                 910         


Arg Pro Lys Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg 
        915                 920                 925             


Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu 
    930                 935                 940                 


Pro Ser Pro Thr Asp Ser Asn Phe Tyr Arg Ala Leu Met Asp Glu Glu 
945                 950                 955                 960 


Asp Met Asp Asp Val Val Asp Ala Asp Glu Tyr Leu Ile Pro Gln Gln 
                965                 970                 975     


Gly Phe Phe Ser Ser Pro Ser Thr Ser Arg Thr Pro Leu Leu Ser Ser 
            980                 985                 990         


Leu Ser Ala Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
        995                 1000                 1005             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1010                 1015                 1020             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1025                 1030                 1035             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1040                 1045                 1050             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1055                 1060                 1065             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1070                 1075                 1080             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1085                 1090                 1095             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1100                 1105                 1110             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1115                 1120                 1125             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1130                 1135                 1140             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1145                 1150                 1155             


Ser Ser  Glu Phe Ile Gly Ala  
    1160                 1165 


<210>  4613
<211>  464
<212>  PRT
<213>  Homo Sapiens

<400>  4613

Met Ser Ser Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg 
1               5                   10                  15      


Cys Arg Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala 
            20                  25                  30          


Gly Cys Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe 
        35                  40                  45              


Arg Asp Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr 
    50                  55                  60                  


Asn Pro Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser 
65                  70                  75                  80  


Phe Gly Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr 
                85                  90                  95      


Asp His Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met 
            100                 105                 110         


Glu Glu Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg 
        115                 120                 125             


Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser 
    130                 135                 140                 


Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser 
145                 150                 155                 160 


Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr 
                165                 170                 175     


His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val 
            180                 185                 190         


Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg 
        195                 200                 205             


Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr 
    210                 215                 220                 


Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr 
225                 230                 235                 240 


Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile 
                245                 250                 255     


Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys 
            260                 265                 270         


Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg 
        275                 280                 285             


Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys 
    290                 295                 300                 


Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys 
305                 310                 315                 320 


Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu 
                325                 330                 335     


Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys 
            340                 345                 350         


His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg 
        355                 360                 365             


Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His 
    370                 375                 380                 


Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu 
385                 390                 395                 400 


Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro 
                405                 410                 415     


Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr 
            420                 425                 430         


Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu 
        435                 440                 445             


Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg 
    450                 455                 460                 


<210>  4614
<211>  77
<212>  PRT
<213>  Homo Sapiens

<400>  4614

Met Ala Ser Val Trp Lys Arg Leu Gln Arg Val Gly Lys His Ala Ser 
1               5                   10                  15      


Lys Phe Gln Phe Val Ala Ser Tyr Gln Glu Leu Met Val Glu Cys Thr 
            20                  25                  30          


Lys Lys Trp Gln Pro Asp Lys Leu Val Val Val Trp Thr Arg Arg Ser 
        35                  40                  45              


Arg Arg Lys Ser Ser Lys Ala His Ser Trp Gln Pro Gly Ile Lys Asn 
    50                  55                  60                  


Pro Tyr Arg Gly Val Val Val Trp Pro Val Pro Glu Asn 
65                  70                  75          


<210>  4615
<211>  1231
<212>  PRT
<213>  Homo Sapiens

<400>  4615

Met Ala Ser Val Trp Lys Arg Leu Gln Arg Val Gly Lys His Ala Ser 
1               5                   10                  15      


Lys Phe Gln Phe Val Ala Ser Tyr Gln Glu Leu Met Val Glu Cys Thr 
            20                  25                  30          


Lys Lys Trp Gln Pro Asp Lys Leu Val Val Val Trp Thr Arg Arg Ser 
        35                  40                  45              


Arg Arg Lys Ser Ser Lys Ala His Ser Trp Gln Pro Gly Ile Lys Asn 
    50                  55                  60                  


Pro Tyr Arg Gly Val Val Val Trp Pro Val Pro Glu Asn Ile Glu Ile 
65                  70                  75                  80  


Thr Val Thr Leu Phe Lys Asp Pro His Ala Glu Glu Phe Glu Asp Lys 
                85                  90                  95      


Glu Trp Thr Phe Val Ile Glu Asn Glu Ser Pro Ser Gly Arg Arg Lys 
            100                 105                 110         


Ala Leu Ala Thr Ser Ser Ile Asn Met Lys Gln Tyr Ala Ser Pro Met 
        115                 120                 125             


Pro Thr Gln Thr Asp Val Lys Leu Lys Phe Lys Pro Leu Ser Lys Lys 
    130                 135                 140                 


Val Val Ser Ala Ala Leu Gln Phe Ser Leu Ser Cys Ile Phe Leu Arg 
145                 150                 155                 160 


Glu Gly Lys Ala Thr Asp Glu Asp Met Gln Ser Leu Ala Ser Leu Met 
                165                 170                 175     


Ser Met Lys Gln Ala Asp Ile Gly Asn Leu Asp Asp Phe Glu Glu Asp 
            180                 185                 190         


Asn Glu Asp Asp Asp Glu Asn Arg Val Asn Gln Glu Glu Lys Ala Ala 
        195                 200                 205             


Lys Ile Thr Glu Ile Val Asn Gln Leu Asn Ala Leu Ser Ser Leu Asp 
    210                 215                 220                 


Glu Asp Gln Asp Asp Cys Ile Lys Gln Ala Asn Met Arg Ser Ala Lys 
225                 230                 235                 240 


Ser Ala Ser Ser Ser Glu Glu Leu Ile Asn Lys Leu Asn Phe Leu Asp 
                245                 250                 255     


Glu Ala Glu Lys Asp Leu Ala Thr Val Asn Ser Asn Pro Phe Asp Asp 
            260                 265                 270         


Pro Asp Ala Ala Glu Leu Asn Pro Phe Gly Asp Pro Asp Ser Glu Glu 
        275                 280                 285             


Pro Ile Thr Glu Thr Ala Ser Pro Arg Lys Thr Glu Asp Ser Phe Tyr 
    290                 295                 300                 


Asn Asn Ser Tyr Asn Pro Phe Lys Glu Val Gln Thr Pro Gln Tyr Leu 
305                 310                 315                 320 


Asn Pro Phe Asp Glu Pro Glu Ala Phe Val Thr Ile Lys Asp Ser Pro 
                325                 330                 335     


Pro Gln Ser Thr Lys Arg Lys Asn Ile Arg Pro Val Asp Met Ser Lys 
            340                 345                 350         


Tyr Leu Tyr Ala Asp Ser Ser Lys Thr Glu Glu Glu Glu Leu Asp Glu 
        355                 360                 365             


Ser Asn Pro Phe Tyr Glu Pro Lys Ser Thr Pro Pro Pro Asn Asn Leu 
    370                 375                 380                 


Val Asn Pro Val Gln Glu Leu Glu Thr Glu Arg Arg Val Lys Arg Lys 
385                 390                 395                 400 


Ala Pro Ala Pro Pro Val Leu Ser Pro Lys Thr Gly Val Leu Asn Glu 
                405                 410                 415     


Asn Thr Val Ser Ala Gly Lys Asp Leu Ser Thr Ser Pro Lys Pro Ser 
            420                 425                 430         


Pro Ile Pro Ser Pro Val Leu Gly Arg Lys Pro Asn Ala Ser Gln Ser 
        435                 440                 445             


Leu Leu Val Trp Cys Lys Glu Val Thr Lys Asn Tyr Arg Gly Val Lys 
    450                 455                 460                 


Ile Thr Asn Phe Thr Thr Ser Trp Arg Asn Gly Leu Ser Phe Cys Ala 
465                 470                 475                 480 


Ile Leu His His Phe Arg Pro Asp Leu Ile Asp Tyr Lys Ser Leu Asn 
                485                 490                 495     


Pro Gln Asp Ile Lys Glu Asn Asn Lys Lys Ala Tyr Asp Gly Phe Ala 
            500                 505                 510         


Ser Ile Gly Ile Ser Arg Leu Leu Glu Pro Ser Asp Met Val Leu Leu 
        515                 520                 525             


Ala Ile Pro Asp Lys Leu Thr Val Met Thr Tyr Leu Tyr Gln Ile Arg 
    530                 535                 540                 


Ala His Phe Ser Gly Gln Glu Leu Asn Val Val Gln Ile Glu Glu Asn 
545                 550                 555                 560 


Ser Ser Lys Ser Thr Tyr Lys Val Gly Asn Tyr Glu Thr Asp Thr Asn 
                565                 570                 575     


Ser Ser Val Asp Gln Glu Lys Phe Tyr Ala Glu Leu Ser Asp Leu Lys 
            580                 585                 590         


Arg Glu Pro Glu Leu Gln Gln Pro Ile Ser Gly Ala Val Asp Phe Leu 
        595                 600                 605             


Ser Gln Asp Asp Ser Val Phe Val Asn Asp Ser Gly Val Gly Glu Ser 
    610                 615                 620                 


Glu Ser Glu His Gln Thr Pro Asp Asp His Leu Ser Pro Ser Thr Ala 
625                 630                 635                 640 


Ser Pro Tyr Cys Arg Arg Thr Lys Ser Asp Thr Glu Pro Gln Lys Ser 
                645                 650                 655     


Gln Gln Ser Ser Gly Arg Thr Ser Gly Ser Asp Asp Pro Gly Ile Cys 
            660                 665                 670         


Ser Asn Thr Asp Ser Thr Gln Ala Gln Val Leu Leu Gly Lys Lys Arg 
        675                 680                 685             


Leu Leu Lys Ala Glu Thr Leu Glu Leu Ser Asp Leu Tyr Val Ser Asp 
    690                 695                 700                 


Lys Lys Lys Asp Met Ser Pro Pro Phe Ile Cys Glu Glu Thr Asp Glu 
705                 710                 715                 720 


Gln Lys Leu Gln Thr Leu Asp Ile Gly Ser Asn Leu Glu Lys Glu Lys 
                725                 730                 735     


Leu Glu Asn Ser Arg Ser Leu Glu Cys Arg Ser Asp Pro Glu Ser Pro 
            740                 745                 750         


Ile Lys Lys Thr Ser Leu Ser Pro Thr Ser Lys Leu Gly Tyr Ser Tyr 
        755                 760                 765             


Ser Arg Asp Leu Asp Leu Ala Lys Lys Lys His Ala Ser Leu Arg Gln 
    770                 775                 780                 


Thr Glu Ser Asp Pro Asp Ala Asp Arg Thr Thr Leu Asn His Ala Asp 
785                 790                 795                 800 


His Ser Ser Lys Ile Val Gln His Arg Leu Leu Ser Arg Gln Glu Glu 
                805                 810                 815     


Leu Lys Glu Arg Ala Arg Val Leu Leu Glu Gln Ala Arg Arg Asp Ala 
            820                 825                 830         


Ala Leu Lys Ala Gly Asn Lys His Asn Thr Asn Thr Ala Thr Pro Phe 
        835                 840                 845             


Cys Asn Arg Gln Leu Ser Asp Gln Gln Asp Glu Glu Arg Arg Arg Gln 
    850                 855                 860                 


Leu Arg Glu Arg Ala Arg Gln Leu Ile Ala Glu Ala Arg Ser Gly Val 
865                 870                 875                 880 


Lys Met Ser Glu Leu Pro Ser Tyr Gly Glu Met Ala Ala Glu Lys Leu 
                885                 890                 895     


Lys Glu Arg Ser Lys Ala Ser Gly Asp Glu Asn Asp Asn Ile Glu Ile 
            900                 905                 910         


Asp Thr Asn Glu Glu Ile Pro Glu Gly Phe Val Val Gly Gly Gly Asp 
        915                 920                 925             


Glu Leu Thr Asn Leu Glu Asn Asp Leu Asp Thr Pro Glu Gln Asn Ser 
    930                 935                 940                 


Lys Leu Val Asp Leu Lys Leu Lys Lys Leu Leu Glu Val Gln Pro Gln 
945                 950                 955                 960 


Val Ala Asn Ser Pro Ser Ser Ala Ala Gln Lys Ala Val Thr Glu Ser 
                965                 970                 975     


Ser Glu Gln Asp Met Lys Ser Gly Thr Glu Asp Leu Arg Thr Glu Arg 
            980                 985                 990         


Leu Gln Lys Thr Thr Glu Arg Phe  Arg Asn Pro Val Val  Phe Ser Lys 
        995                 1000                 1005             


Asp Ser  Thr Val Arg Lys Thr  Gln Leu Gln Ser Phe  Ser Gln Tyr 
    1010                 1015                 1020             


Ile Glu  Asn Arg Pro Glu Met  Lys Arg Gln Arg Ser  Ile Gln Glu 
    1025                 1030                 1035             


Asp Thr  Lys Lys Gly Asn Glu  Glu Lys Ala Ala Ile  Thr Glu Thr 
    1040                 1045                 1050             


Gln Arg  Lys Pro Ser Glu Asp  Glu Val Leu Asn Lys  Gly Phe Lys 
    1055                 1060                 1065             


Asp Thr  Ser Gln Tyr Val Val  Gly Glu Leu Ala Ala  Leu Glu Asn 
    1070                 1075                 1080             


Glu Gln  Lys Gln Ile Asp Thr  Arg Ala Ala Leu Val  Glu Lys Arg 
    1085                 1090                 1095             


Leu Arg  Tyr Leu Met Asp Thr  Gly Arg Asn Thr Glu  Glu Glu Glu 
    1100                 1105                 1110             


Ala Met  Met Gln Glu Trp Phe  Met Leu Val Asn Lys  Lys Asn Ala 
    1115                 1120                 1125             


Leu Ile  Arg Arg Met Asn Gln  Leu Ser Leu Leu Glu  Lys Glu His 
    1130                 1135                 1140             


Asp Leu  Glu Arg Arg Tyr Glu  Leu Leu Asn Arg Glu  Leu Arg Ala 
    1145                 1150                 1155             


Met Leu  Ala Ile Glu Asp Trp  Gln Lys Thr Glu Ala  Gln Lys Arg 
    1160                 1165                 1170             


Arg Glu  Gln Leu Leu Leu Asp  Glu Leu Val Ala Leu  Val Asn Lys 
    1175                 1180                 1185             


Arg Asp  Ala Leu Val Arg Asp  Leu Asp Ala Gln Glu  Lys Gln Ala 
    1190                 1195                 1200             


Glu Glu  Glu Asp Glu His Leu  Glu Arg Thr Leu Glu  Gln Asn Lys 
    1205                 1210                 1215             


Gly Lys  Met Ala Lys Lys Glu  Glu Lys Cys Val Leu  Gln 
    1220                 1225                 1230     


<210>  4616
<211>  1160
<212>  PRT
<213>  Homo Sapiens

<400>  4616

Met Ala Ser Val Trp Lys Arg Leu Gln Arg Val Gly Lys His Ala Ser 
1               5                   10                  15      


Lys Phe Gln Phe Val Ala Ser Tyr Gln Glu Leu Met Val Glu Cys Thr 
            20                  25                  30          


Lys Lys Trp Gln Pro Asp Lys Leu Val Val Val Trp Thr Arg Arg Ser 
        35                  40                  45              


Arg Arg Lys Ser Ser Lys Ala His Ser Trp Gln Pro Gly Ile Lys Asn 
    50                  55                  60                  


Pro Tyr Arg Gly Val Val Val Trp Pro Val Pro Glu Asn Ile Glu Ile 
65                  70                  75                  80  


Thr Val Thr Leu Phe Lys Asp Pro His Ala Glu Glu Phe Glu Asp Lys 
                85                  90                  95      


Glu Trp Thr Phe Val Ile Glu Asn Glu Ser Pro Ser Gly Arg Arg Lys 
            100                 105                 110         


Ala Leu Ala Thr Ser Ser Ile Asn Met Lys Gln Tyr Ala Ser Pro Met 
        115                 120                 125             


Pro Thr Gln Thr Asp Val Lys Leu Lys Phe Lys Pro Leu Ser Lys Lys 
    130                 135                 140                 


Val Val Ser Ala Ala Leu Gln Phe Ser Leu Ser Cys Ile Phe Leu Arg 
145                 150                 155                 160 


Glu Gly Lys Ala Thr Asp Glu Asp Met Gln Ser Leu Ala Ser Leu Met 
                165                 170                 175     


Ser Met Lys Gln Ala Asp Ile Gly Asn Leu Asp Asp Phe Glu Glu Asp 
            180                 185                 190         


Asn Glu Asp Asp Asp Glu Asn Arg Val Asn Gln Glu Glu Lys Ala Ala 
        195                 200                 205             


Lys Ile Thr Glu Leu Ile Asn Lys Leu Asn Phe Leu Asp Glu Ala Glu 
    210                 215                 220                 


Lys Asp Leu Ala Thr Val Asn Ser Asn Pro Phe Asp Asp Pro Asp Ala 
225                 230                 235                 240 


Ala Glu Leu Asn Pro Phe Gly Asp Pro Asp Ser Glu Glu Pro Ile Thr 
                245                 250                 255     


Glu Thr Ala Ser Pro Arg Lys Thr Glu Asp Ser Phe Tyr Asn Asn Ser 
            260                 265                 270         


Tyr Asn Pro Phe Lys Glu Val Gln Thr Pro Gln Tyr Leu Asn Pro Phe 
        275                 280                 285             


Asp Glu Pro Glu Ala Phe Val Thr Ile Lys Asp Ser Pro Pro Gln Ser 
    290                 295                 300                 


Thr Lys Arg Lys Asn Ile Arg Pro Val Asp Met Ser Lys Tyr Leu Tyr 
305                 310                 315                 320 


Ala Asp Ser Ser Lys Thr Glu Glu Glu Glu Leu Asp Glu Ser Asn Pro 
                325                 330                 335     


Phe Tyr Glu Pro Lys Ser Thr Pro Pro Pro Asn Asn Leu Val Asn Pro 
            340                 345                 350         


Val Gln Glu Leu Glu Thr Glu Arg Arg Val Lys Arg Lys Ala Pro Ala 
        355                 360                 365             


Pro Pro Val Leu Ser Pro Lys Thr Gly Val Leu Asn Glu Asn Thr Val 
    370                 375                 380                 


Ser Ala Gly Lys Asp Leu Ser Thr Ser Pro Lys Pro Ser Pro Ile Pro 
385                 390                 395                 400 


Ser Pro Val Leu Gly Arg Lys Pro Asn Ala Ser Gln Ser Leu Leu Val 
                405                 410                 415     


Trp Cys Lys Glu Val Thr Lys Asn Tyr Arg Gly Val Lys Ile Thr Asn 
            420                 425                 430         


Phe Thr Thr Ser Trp Arg Asn Gly Leu Ser Phe Cys Ala Ile Leu His 
        435                 440                 445             


His Phe Arg Pro Asp Leu Ile Asp Tyr Lys Ser Leu Asn Pro Gln Asp 
    450                 455                 460                 


Ile Lys Glu Asn Asn Lys Lys Ala Tyr Asp Gly Phe Ala Ser Ile Gly 
465                 470                 475                 480 


Ile Ser Arg Leu Leu Glu Pro Ser Asp Met Val Leu Leu Ala Ile Pro 
                485                 490                 495     


Asp Lys Leu Thr Val Met Thr Tyr Leu Tyr Gln Ile Arg Ala His Phe 
            500                 505                 510         


Ser Gly Gln Glu Leu Asn Val Val Gln Ile Glu Glu Asn Ser Ser Lys 
        515                 520                 525             


Ser Thr Tyr Lys Val Gly Asn Tyr Glu Thr Asp Thr Asn Ser Ser Val 
    530                 535                 540                 


Asp Gln Glu Lys Phe Tyr Ala Glu Leu Ser Asp Leu Lys Arg Glu Pro 
545                 550                 555                 560 


Glu Leu Gln Gln Pro Ile Ser Gly Ala Val Asp Phe Leu Ser Gln Asp 
                565                 570                 575     


Asp Ser Val Phe Val Asn Asp Ser Gly Val Gly Glu Ser Glu Ser Glu 
            580                 585                 590         


His Gln Thr Pro Asp Asp His Leu Ser Pro Ser Thr Ala Ser Pro Tyr 
        595                 600                 605             


Cys Arg Arg Thr Lys Ser Asp Thr Glu Pro Gln Lys Ser Gln Gln Ser 
    610                 615                 620                 


Ser Gly Arg Thr Ser Gly Ser Asp Asp Pro Gly Ile Cys Ser Asn Thr 
625                 630                 635                 640 


Asp Ser Thr Gln Ala Gln Val Leu Leu Gly Lys Lys Arg Leu Leu Lys 
                645                 650                 655     


Ala Glu Thr Leu Glu Leu Ser Asp Leu Tyr Val Ser Asp Lys Lys Lys 
            660                 665                 670         


Asp Met Ser Pro Pro Phe Ile Cys Glu Glu Thr Asp Glu Gln Lys Leu 
        675                 680                 685             


Gln Thr Leu Asp Ile Gly Ser Asn Leu Glu Lys Glu Lys Leu Glu Asn 
    690                 695                 700                 


Ser Arg Ser Leu Glu Cys Arg Ser Asp Pro Glu Ser Pro Ile Lys Lys 
705                 710                 715                 720 


Thr Ser Leu Ser Pro Thr Ser Lys Leu Gly Tyr Ser Tyr Ser Arg Asp 
                725                 730                 735     


Leu Asp Leu Ala Lys Lys Lys His Ala Ser Leu Arg Gln Thr Glu Ser 
            740                 745                 750         


Asp Pro Asp Ala Asp Arg Thr Thr Leu Asn His Ala Asp His Ser Ser 
        755                 760                 765             


Lys Ile Val Gln His Arg Leu Leu Ser Arg Gln Glu Glu Leu Lys Glu 
    770                 775                 780                 


Arg Ala Arg Val Leu Leu Glu Gln Ala Arg Arg Asp Ala Ala Leu Lys 
785                 790                 795                 800 


Ala Gly Asn Lys His Asn Thr Asn Thr Ala Thr Pro Phe Cys Asn Arg 
                805                 810                 815     


Gln Leu Ser Asp Gln Gln Asp Glu Glu Arg Arg Arg Gln Leu Arg Glu 
            820                 825                 830         


Arg Ala Arg Gln Leu Ile Ala Glu Ala Arg Ser Gly Val Lys Met Ser 
        835                 840                 845             


Glu Leu Pro Ser Tyr Gly Glu Met Ala Ala Glu Lys Leu Lys Glu Arg 
    850                 855                 860                 


Ser Lys Ala Ser Gly Glu Gln Asn Ser Lys Leu Val Asp Leu Lys Leu 
865                 870                 875                 880 


Lys Lys Leu Leu Glu Val Gln Pro Gln Val Ala Asn Ser Pro Ser Ser 
                885                 890                 895     


Ala Ala Gln Lys Ala Val Thr Glu Ser Ser Glu Gln Asp Met Lys Ser 
            900                 905                 910         


Gly Thr Glu Asp Leu Arg Thr Glu Arg Leu Gln Lys Thr Thr Glu Arg 
        915                 920                 925             


Phe Arg Asn Pro Val Val Phe Ser Lys Asp Ser Thr Val Arg Lys Thr 
    930                 935                 940                 


Gln Leu Gln Ser Phe Ser Gln Tyr Ile Glu Asn Arg Pro Glu Met Lys 
945                 950                 955                 960 


Arg Gln Arg Ser Ile Gln Glu Asp Thr Lys Lys Gly Asn Glu Glu Lys 
                965                 970                 975     


Ala Ala Ile Thr Glu Thr Gln Arg Lys Pro Ser Glu Asp Glu Val Leu 
            980                 985                 990         


Asn Lys Gly Phe Lys Asp Thr Ser  Gln Tyr Val Val Gly  Glu Leu Ala 
        995                 1000                 1005             


Ala Leu  Glu Asn Glu Gln Lys  Gln Ile Asp Thr Arg  Ala Ala Leu 
    1010                 1015                 1020             


Val Glu  Lys Arg Leu Arg Tyr  Leu Met Asp Thr Gly  Arg Asn Thr 
    1025                 1030                 1035             


Glu Glu  Glu Glu Ala Met Met  Gln Glu Trp Phe Met  Leu Val Asn 
    1040                 1045                 1050             


Lys Lys  Asn Ala Leu Ile Arg  Arg Met Asn Gln Leu  Ser Leu Leu 
    1055                 1060                 1065             


Glu Lys  Glu His Asp Leu Glu  Arg Arg Tyr Glu Leu  Leu Asn Arg 
    1070                 1075                 1080             


Glu Leu  Arg Ala Met Leu Ala  Ile Glu Asp Trp Gln  Lys Thr Glu 
    1085                 1090                 1095             


Ala Gln  Lys Arg Arg Glu Gln  Leu Leu Leu Asp Glu  Leu Val Ala 
    1100                 1105                 1110             


Leu Val  Asn Lys Arg Asp Ala  Leu Val Arg Asp Leu  Asp Ala Gln 
    1115                 1120                 1125             


Glu Lys  Gln Ala Glu Glu Glu  Asp Glu His Leu Glu  Arg Thr Leu 
    1130                 1135                 1140             


Glu Gln  Asn Lys Gly Lys Met  Ala Lys Lys Glu Glu  Lys Cys Val 
    1145                 1150                 1155             


Leu Gln  
    1160 


<210>  4617
<211>  310
<212>  PRT
<213>  Homo Sapiens

<400>  4617

Met Ala Ser Val Trp Lys Arg Leu Gln Arg Val Gly Lys His Ala Ser 
1               5                   10                  15      


Lys Phe Gln Phe Val Ala Ser Tyr Gln Glu Leu Met Val Glu Cys Thr 
            20                  25                  30          


Lys Lys Trp Gln Pro Asp Lys Leu Val Val Val Trp Thr Arg Arg Ser 
        35                  40                  45              


Arg Arg Lys Ser Ser Lys Ala His Ser Trp Gln Pro Gly Ile Lys Asn 
    50                  55                  60                  


Pro Tyr Arg Gly Val Val Val Trp Pro Val Pro Glu Asn Ile Glu Ile 
65                  70                  75                  80  


Thr Val Thr Leu Phe Lys Asp Pro His Ala Glu Glu Phe Glu Asp Lys 
                85                  90                  95      


Glu Trp Thr Phe Val Ile Glu Asn Glu Ser Pro Ser Gly Arg Arg Lys 
            100                 105                 110         


Ala Leu Ala Thr Ser Ser Ile Asn Met Lys Gln Tyr Ala Ser Pro Met 
        115                 120                 125             


Pro Thr Gln Thr Asp Val Lys Leu Lys Phe Lys Pro Leu Ser Lys Lys 
    130                 135                 140                 


Val Val Ser Ala Ala Leu Gln Phe Ser Leu Ser Cys Ile Phe Leu Arg 
145                 150                 155                 160 


Glu Gly Lys Ala Thr Asp Glu Asp Met Gln Ser Leu Ala Ser Leu Met 
                165                 170                 175     


Ser Met Lys Gln Ala Asp Ile Gly Asn Leu Asp Asp Phe Glu Glu Asp 
            180                 185                 190         


Asn Glu Asp Asp Asp Glu Asn Arg Val Asn Gln Glu Glu Lys Ala Ala 
        195                 200                 205             


Lys Ile Thr Glu Leu Ile Asn Lys Leu Asn Phe Leu Asp Glu Ala Glu 
    210                 215                 220                 


Lys Asp Leu Ala Thr Val Asn Ser Asn Pro Phe Asp Asp Pro Asp Ala 
225                 230                 235                 240 


Ala Glu Leu Asn Pro Phe Gly Asp Pro Asp Ser Glu Glu Pro Ile Thr 
                245                 250                 255     


Glu Thr Ala Ser Pro Arg Lys Thr Glu Asp Ser Phe Tyr Asn Asn Ser 
            260                 265                 270         


Tyr Asn Pro Phe Lys Glu Val Gln Thr Pro Gln Tyr Leu Asn Pro Phe 
        275                 280                 285             


Asp Glu Pro Glu Ala Phe Val Thr Ile Lys Asp Ser Pro Pro Gln Ser 
    290                 295                 300                 


Thr Lys Arg Lys Asn Ile 
305                 310 


<210>  4618
<211>  1196
<212>  PRT
<213>  Homo Sapiens

<400>  4618

Met Ala Ser Val Trp Lys Arg Leu Gln Arg Val Gly Lys His Ala Ser 
1               5                   10                  15      


Lys Phe Gln Phe Val Ala Ser Tyr Gln Glu Leu Met Val Glu Cys Thr 
            20                  25                  30          


Lys Lys Trp Gln Pro Asp Lys Leu Val Val Val Trp Thr Arg Arg Ser 
        35                  40                  45              


Arg Arg Lys Ser Ser Lys Ala His Ser Trp Gln Pro Gly Ile Lys Asn 
    50                  55                  60                  


Pro Tyr Arg Gly Val Val Val Trp Pro Val Pro Glu Asn Ile Glu Ile 
65                  70                  75                  80  


Thr Val Thr Leu Phe Lys Asp Pro His Ala Glu Glu Phe Glu Asp Lys 
                85                  90                  95      


Glu Trp Thr Phe Val Ile Glu Asn Glu Ser Pro Ser Gly Arg Arg Lys 
            100                 105                 110         


Ala Leu Ala Thr Ser Ser Ile Asn Met Lys Gln Tyr Ala Ser Pro Met 
        115                 120                 125             


Pro Thr Gln Thr Asp Val Lys Leu Lys Phe Lys Pro Leu Ser Lys Lys 
    130                 135                 140                 


Val Val Ser Ala Ala Leu Gln Phe Ser Leu Ser Cys Ile Phe Leu Arg 
145                 150                 155                 160 


Glu Gly Lys Ala Thr Asp Glu Asp Met Gln Ser Leu Ala Ser Leu Met 
                165                 170                 175     


Ser Met Lys Gln Ala Asp Ile Gly Asn Leu Asp Asp Phe Glu Glu Asp 
            180                 185                 190         


Asn Glu Asp Asp Asp Glu Asn Arg Val Asn Gln Glu Glu Lys Ala Ala 
        195                 200                 205             


Lys Ile Thr Glu Leu Ile Asn Lys Leu Asn Phe Leu Asp Glu Ala Glu 
    210                 215                 220                 


Lys Asp Leu Ala Thr Val Asn Ser Asn Pro Phe Asp Asp Pro Asp Ala 
225                 230                 235                 240 


Ala Glu Leu Asn Pro Phe Gly Asp Pro Asp Ser Glu Glu Pro Ile Thr 
                245                 250                 255     


Glu Thr Ala Ser Pro Arg Lys Thr Glu Asp Ser Phe Tyr Asn Asn Ser 
            260                 265                 270         


Tyr Asn Pro Phe Lys Glu Val Gln Thr Pro Gln Tyr Leu Asn Pro Phe 
        275                 280                 285             


Asp Glu Pro Glu Ala Phe Val Thr Ile Lys Asp Ser Pro Pro Gln Ser 
    290                 295                 300                 


Thr Lys Arg Lys Asn Ile Arg Pro Val Asp Met Ser Lys Tyr Leu Tyr 
305                 310                 315                 320 


Ala Asp Ser Ser Lys Thr Glu Glu Glu Glu Leu Asp Glu Ser Asn Pro 
                325                 330                 335     


Phe Tyr Glu Pro Lys Ser Thr Pro Pro Pro Asn Asn Leu Val Asn Pro 
            340                 345                 350         


Val Gln Glu Leu Glu Thr Glu Arg Arg Val Lys Arg Lys Ala Pro Ala 
        355                 360                 365             


Pro Pro Val Leu Ser Pro Lys Thr Gly Val Leu Asn Glu Asn Thr Val 
    370                 375                 380                 


Ser Ala Gly Lys Asp Leu Ser Thr Ser Pro Lys Pro Ser Pro Ile Pro 
385                 390                 395                 400 


Ser Pro Val Leu Gly Arg Lys Pro Asn Ala Ser Gln Ser Leu Leu Val 
                405                 410                 415     


Trp Cys Lys Glu Val Thr Lys Asn Tyr Arg Gly Val Lys Ile Thr Asn 
            420                 425                 430         


Phe Thr Thr Ser Trp Arg Asn Gly Leu Ser Phe Cys Ala Ile Leu His 
        435                 440                 445             


His Phe Arg Pro Asp Leu Ile Asp Tyr Lys Ser Leu Asn Pro Gln Asp 
    450                 455                 460                 


Ile Lys Glu Asn Asn Lys Lys Ala Tyr Asp Gly Phe Ala Ser Ile Gly 
465                 470                 475                 480 


Ile Ser Arg Leu Leu Glu Pro Ser Asp Met Val Leu Leu Ala Ile Pro 
                485                 490                 495     


Asp Lys Leu Thr Val Met Thr Tyr Leu Tyr Gln Ile Arg Ala His Phe 
            500                 505                 510         


Ser Gly Gln Glu Leu Asn Val Val Gln Ile Glu Glu Asn Ser Ser Lys 
        515                 520                 525             


Ser Thr Tyr Lys Val Gly Asn Tyr Glu Thr Asp Thr Asn Ser Ser Val 
    530                 535                 540                 


Asp Gln Glu Lys Phe Tyr Ala Glu Leu Ser Asp Leu Lys Arg Glu Pro 
545                 550                 555                 560 


Glu Leu Gln Gln Pro Ile Ser Gly Ala Val Asp Phe Leu Ser Gln Asp 
                565                 570                 575     


Asp Ser Val Phe Val Asn Asp Ser Gly Val Gly Glu Ser Glu Ser Glu 
            580                 585                 590         


His Gln Thr Pro Asp Asp His Leu Ser Pro Ser Thr Ala Ser Pro Tyr 
        595                 600                 605             


Cys Arg Arg Thr Lys Ser Asp Thr Glu Pro Gln Lys Ser Gln Gln Ser 
    610                 615                 620                 


Ser Gly Arg Thr Ser Gly Ser Asp Asp Pro Gly Ile Cys Ser Asn Thr 
625                 630                 635                 640 


Asp Ser Thr Gln Ala Gln Val Leu Leu Gly Lys Lys Arg Leu Leu Lys 
                645                 650                 655     


Ala Glu Thr Leu Glu Leu Ser Asp Leu Tyr Val Ser Asp Lys Lys Lys 
            660                 665                 670         


Asp Met Ser Pro Pro Phe Ile Cys Glu Glu Thr Asp Glu Gln Lys Leu 
        675                 680                 685             


Gln Thr Leu Asp Ile Gly Ser Asn Leu Glu Lys Glu Lys Leu Glu Asn 
    690                 695                 700                 


Ser Arg Ser Leu Glu Cys Arg Ser Asp Pro Glu Ser Pro Ile Lys Lys 
705                 710                 715                 720 


Thr Ser Leu Ser Pro Thr Ser Lys Leu Gly Tyr Ser Tyr Ser Arg Asp 
                725                 730                 735     


Leu Asp Leu Ala Lys Lys Lys His Ala Ser Leu Arg Gln Thr Glu Ser 
            740                 745                 750         


Asp Pro Asp Ala Asp Arg Thr Thr Leu Asn His Ala Asp His Ser Ser 
        755                 760                 765             


Lys Ile Val Gln His Arg Leu Leu Ser Arg Gln Glu Glu Leu Lys Glu 
    770                 775                 780                 


Arg Ala Arg Val Leu Leu Glu Gln Ala Arg Arg Asp Ala Ala Leu Lys 
785                 790                 795                 800 


Ala Gly Asn Lys His Asn Thr Asn Thr Ala Thr Pro Phe Cys Asn Arg 
                805                 810                 815     


Gln Leu Ser Asp Gln Gln Asp Glu Glu Arg Arg Arg Gln Leu Arg Glu 
            820                 825                 830         


Arg Ala Arg Gln Leu Ile Ala Glu Ala Arg Ser Gly Val Lys Met Ser 
        835                 840                 845             


Glu Leu Pro Ser Tyr Gly Glu Met Ala Ala Glu Lys Leu Lys Glu Arg 
    850                 855                 860                 


Ser Lys Ala Ser Gly Asp Glu Asn Asp Asn Ile Glu Ile Asp Thr Asn 
865                 870                 875                 880 


Glu Glu Ile Pro Glu Gly Phe Val Val Gly Gly Gly Asp Glu Leu Thr 
                885                 890                 895     


Asn Leu Glu Asn Asp Leu Asp Thr Pro Glu Gln Asn Ser Lys Leu Val 
            900                 905                 910         


Asp Leu Lys Leu Lys Lys Leu Leu Glu Val Gln Pro Gln Val Ala Asn 
        915                 920                 925             


Ser Pro Ser Ser Ala Ala Gln Lys Ala Val Thr Glu Ser Ser Glu Gln 
    930                 935                 940                 


Asp Met Lys Ser Gly Thr Glu Asp Leu Arg Thr Glu Arg Leu Gln Lys 
945                 950                 955                 960 


Thr Thr Glu Arg Phe Arg Asn Pro Val Val Phe Ser Lys Asp Ser Thr 
                965                 970                 975     


Val Arg Lys Thr Gln Leu Gln Ser Phe Ser Gln Tyr Ile Glu Asn Arg 
            980                 985                 990         


Pro Glu Met Lys Arg Gln Arg Ser  Ile Gln Glu Asp Thr  Lys Lys Gly 
        995                 1000                 1005             


Asn Glu  Glu Lys Ala Ala Ile  Thr Glu Thr Gln Arg  Lys Pro Ser 
    1010                 1015                 1020             


Glu Asp  Glu Val Leu Asn Lys  Gly Phe Lys Asp Thr  Ser Gln Tyr 
    1025                 1030                 1035             


Val Val  Gly Glu Leu Ala Ala  Leu Glu Asn Glu Gln  Lys Gln Ile 
    1040                 1045                 1050             


Asp Thr  Arg Ala Ala Leu Val  Glu Lys Arg Leu Arg  Tyr Leu Met 
    1055                 1060                 1065             


Asp Thr  Gly Arg Asn Thr Glu  Glu Glu Glu Ala Met  Met Gln Glu 
    1070                 1075                 1080             


Trp Phe  Met Leu Val Asn Lys  Lys Asn Ala Leu Ile  Arg Arg Met 
    1085                 1090                 1095             


Asn Gln  Leu Ser Leu Leu Glu  Lys Glu His Asp Leu  Glu Arg Arg 
    1100                 1105                 1110             


Tyr Glu  Leu Leu Asn Arg Glu  Leu Arg Ala Met Leu  Ala Ile Glu 
    1115                 1120                 1125             


Asp Trp  Gln Lys Thr Glu Ala  Gln Lys Arg Arg Glu  Gln Leu Leu 
    1130                 1135                 1140             


Leu Asp  Glu Leu Val Ala Leu  Val Asn Lys Arg Asp  Ala Leu Val 
    1145                 1150                 1155             


Arg Asp  Leu Asp Ala Gln Glu  Lys Gln Ala Glu Glu  Glu Asp Glu 
    1160                 1165                 1170             


His Leu  Glu Arg Thr Leu Glu  Gln Asn Lys Gly Lys  Met Ala Lys 
    1175                 1180                 1185             


Lys Glu  Glu Lys Cys Val Leu  Gln 
    1190                 1195     


<210>  4619
<211>  1160
<212>  PRT
<213>  Homo Sapiens

<400>  4619

Met Ala Ser Val Trp Lys Arg Leu Gln Arg Val Gly Lys His Ala Ser 
1               5                   10                  15      


Lys Phe Gln Phe Val Ala Ser Tyr Gln Glu Leu Met Val Glu Cys Thr 
            20                  25                  30          


Lys Lys Trp Gln Pro Asp Lys Leu Val Val Val Trp Thr Arg Arg Ser 
        35                  40                  45              


Arg Arg Lys Ser Ser Lys Ala His Ser Trp Gln Pro Gly Ile Lys Asn 
    50                  55                  60                  


Pro Tyr Arg Gly Val Val Val Trp Pro Val Pro Glu Asn Ile Glu Ile 
65                  70                  75                  80  


Thr Val Thr Leu Phe Lys Asp Pro His Ala Glu Glu Phe Glu Asp Lys 
                85                  90                  95      


Glu Trp Thr Phe Val Ile Glu Asn Glu Ser Pro Ser Gly Arg Arg Lys 
            100                 105                 110         


Ala Leu Ala Thr Ser Ser Ile Asn Met Lys Gln Tyr Ala Ser Pro Met 
        115                 120                 125             


Pro Thr Gln Thr Asp Val Lys Leu Lys Phe Lys Pro Leu Ser Lys Lys 
    130                 135                 140                 


Val Val Ser Ala Ala Leu Gln Phe Ser Leu Ser Cys Ile Phe Leu Arg 
145                 150                 155                 160 


Glu Gly Lys Ala Thr Asp Glu Asp Met Gln Ser Leu Ala Ser Leu Met 
                165                 170                 175     


Ser Met Lys Gln Ala Asp Ile Gly Asn Leu Asp Asp Phe Glu Glu Asp 
            180                 185                 190         


Asn Glu Asp Asp Asp Glu Asn Arg Val Asn Gln Glu Glu Lys Ala Ala 
        195                 200                 205             


Lys Ile Thr Glu Leu Ile Asn Lys Leu Asn Phe Leu Asp Glu Ala Glu 
    210                 215                 220                 


Lys Asp Leu Ala Thr Val Asn Ser Asn Pro Phe Asp Asp Pro Asp Ala 
225                 230                 235                 240 


Ala Glu Leu Asn Pro Phe Gly Asp Pro Asp Ser Glu Glu Pro Ile Thr 
                245                 250                 255     


Glu Thr Ala Ser Pro Arg Lys Thr Glu Asp Ser Phe Tyr Asn Asn Ser 
            260                 265                 270         


Tyr Asn Pro Phe Lys Glu Val Gln Thr Pro Gln Tyr Leu Asn Pro Phe 
        275                 280                 285             


Asp Glu Pro Glu Ala Phe Val Thr Ile Lys Asp Ser Pro Pro Gln Ser 
    290                 295                 300                 


Thr Lys Arg Lys Asn Ile Arg Pro Val Asp Met Ser Lys Tyr Leu Tyr 
305                 310                 315                 320 


Ala Asp Ser Ser Lys Thr Glu Glu Glu Glu Leu Asp Glu Ser Asn Pro 
                325                 330                 335     


Phe Tyr Glu Pro Lys Ser Thr Pro Pro Pro Asn Asn Leu Val Asn Pro 
            340                 345                 350         


Val Gln Glu Leu Glu Thr Glu Arg Arg Val Lys Arg Lys Ala Pro Ala 
        355                 360                 365             


Pro Pro Val Leu Ser Pro Lys Thr Gly Val Leu Asn Glu Asn Thr Val 
    370                 375                 380                 


Ser Ala Gly Lys Asp Leu Ser Thr Ser Pro Lys Pro Ser Pro Ile Pro 
385                 390                 395                 400 


Ser Pro Val Leu Gly Arg Lys Pro Asn Ala Ser Gln Ser Leu Leu Val 
                405                 410                 415     


Trp Cys Lys Glu Val Thr Lys Asn Tyr Arg Gly Val Lys Ile Thr Asn 
            420                 425                 430         


Phe Thr Thr Ser Trp Arg Asn Gly Leu Ser Phe Cys Ala Ile Leu His 
        435                 440                 445             


His Phe Arg Pro Asp Leu Ile Asp Tyr Lys Ser Leu Asn Pro Gln Asp 
    450                 455                 460                 


Ile Lys Glu Asn Asn Lys Lys Ala Tyr Asp Gly Phe Ala Ser Ile Gly 
465                 470                 475                 480 


Ile Ser Arg Leu Leu Glu Pro Ser Asp Met Val Leu Leu Ala Ile Pro 
                485                 490                 495     


Asp Lys Leu Thr Val Met Thr Tyr Leu Tyr Gln Ile Arg Ala His Phe 
            500                 505                 510         


Ser Gly Gln Glu Leu Asn Val Val Gln Ile Glu Glu Asn Ser Ser Lys 
        515                 520                 525             


Ser Thr Tyr Lys Val Gly Asn Tyr Glu Thr Asp Thr Asn Ser Ser Val 
    530                 535                 540                 


Asp Gln Glu Lys Phe Tyr Ala Glu Leu Ser Asp Leu Lys Arg Glu Pro 
545                 550                 555                 560 


Glu Leu Gln Gln Pro Ile Ser Gly Ala Val Asp Phe Leu Ser Gln Asp 
                565                 570                 575     


Asp Ser Val Phe Val Asn Asp Ser Gly Val Gly Glu Ser Glu Ser Glu 
            580                 585                 590         


His Gln Thr Pro Asp Asp His Leu Ser Pro Ser Thr Ala Ser Pro Tyr 
        595                 600                 605             


Cys Arg Arg Thr Lys Ser Asp Thr Glu Pro Gln Lys Ser Gln Gln Ser 
    610                 615                 620                 


Ser Gly Arg Thr Ser Gly Ser Asp Asp Pro Gly Ile Cys Ser Asn Thr 
625                 630                 635                 640 


Asp Ser Thr Gln Ala Gln Val Leu Leu Gly Lys Lys Arg Leu Leu Lys 
                645                 650                 655     


Ala Glu Thr Leu Glu Leu Ser Asp Leu Tyr Val Ser Asp Lys Lys Lys 
            660                 665                 670         


Asp Met Ser Pro Pro Phe Ile Cys Glu Glu Thr Asp Glu Gln Lys Leu 
        675                 680                 685             


Gln Thr Leu Asp Ile Gly Ser Asn Leu Glu Lys Glu Lys Leu Glu Asn 
    690                 695                 700                 


Ser Arg Ser Leu Glu Cys Arg Ser Asp Pro Glu Ser Pro Ile Lys Lys 
705                 710                 715                 720 


Thr Ser Leu Ser Pro Thr Ser Lys Leu Gly Tyr Ser Tyr Ser Arg Asp 
                725                 730                 735     


Leu Asp Leu Ala Lys Lys Lys His Ala Ser Leu Arg Gln Thr Glu Ser 
            740                 745                 750         


Asp Pro Asp Ala Asp Arg Thr Thr Leu Asn His Ala Asp His Ser Ser 
        755                 760                 765             


Lys Ile Val Gln His Arg Leu Leu Ser Arg Gln Glu Glu Leu Lys Glu 
    770                 775                 780                 


Arg Ala Arg Val Leu Leu Glu Gln Ala Arg Arg Asp Ala Ala Leu Lys 
785                 790                 795                 800 


Ala Gly Asn Lys His Asn Thr Asn Thr Ala Thr Pro Phe Cys Asn Arg 
                805                 810                 815     


Gln Leu Ser Asp Gln Gln Asp Glu Glu Arg Arg Arg Gln Leu Arg Glu 
            820                 825                 830         


Arg Ala Arg Gln Leu Ile Ala Glu Ala Arg Ser Gly Val Lys Met Ser 
        835                 840                 845             


Glu Leu Pro Ser Tyr Gly Glu Met Ala Ala Glu Lys Leu Lys Glu Arg 
    850                 855                 860                 


Ser Lys Ala Ser Gly Glu Gln Asn Ser Lys Leu Val Asp Leu Lys Leu 
865                 870                 875                 880 


Lys Lys Leu Leu Glu Val Gln Pro Gln Val Ala Asn Ser Pro Ser Ser 
                885                 890                 895     


Ala Ala Gln Lys Ala Val Thr Glu Ser Ser Glu Gln Asp Met Lys Ser 
            900                 905                 910         


Gly Thr Glu Asp Leu Arg Thr Glu Arg Leu Gln Lys Thr Thr Glu Arg 
        915                 920                 925             


Phe Arg Asn Pro Val Val Phe Ser Lys Asp Ser Thr Val Arg Lys Thr 
    930                 935                 940                 


Gln Leu Gln Ser Phe Ser Gln Tyr Ile Glu Asn Arg Pro Glu Met Lys 
945                 950                 955                 960 


Arg Gln Arg Ser Ile Gln Glu Asp Thr Lys Lys Gly Asn Glu Glu Lys 
                965                 970                 975     


Ala Ala Ile Thr Glu Thr Gln Arg Lys Pro Ser Glu Asp Glu Val Leu 
            980                 985                 990         


Asn Lys Gly Phe Lys Asp Thr Ser  Gln Tyr Val Val Gly  Glu Leu Ala 
        995                 1000                 1005             


Ala Leu  Glu Asn Glu Gln Lys  Gln Ile Asp Thr Arg  Ala Ala Leu 
    1010                 1015                 1020             


Val Glu  Lys Arg Leu Arg Tyr  Leu Met Asp Thr Gly  Arg Asn Thr 
    1025                 1030                 1035             


Glu Glu  Glu Glu Ala Met Met  Gln Glu Trp Phe Met  Leu Val Asn 
    1040                 1045                 1050             


Lys Lys  Asn Ala Leu Ile Arg  Arg Met Asn Gln Leu  Ser Leu Leu 
    1055                 1060                 1065             


Glu Lys  Glu His Asp Leu Glu  Arg Arg Tyr Glu Leu  Leu Asn Arg 
    1070                 1075                 1080             


Glu Leu  Arg Ala Met Leu Ala  Ile Glu Asp Trp Gln  Lys Thr Glu 
    1085                 1090                 1095             


Ala Gln  Lys Arg Arg Glu Gln  Leu Leu Leu Asp Glu  Leu Val Ala 
    1100                 1105                 1110             


Leu Val  Asn Lys Arg Asp Ala  Leu Val Arg Asp Leu  Asp Ala Gln 
    1115                 1120                 1125             


Glu Lys  Gln Ala Glu Glu Glu  Asp Glu His Leu Glu  Arg Thr Leu 
    1130                 1135                 1140             


Glu Gln  Asn Lys Gly Lys Met  Ala Lys Lys Glu Glu  Lys Cys Val 
    1145                 1150                 1155             


Leu Gln  
    1160 


<210>  4620
<211>  41
<212>  PRT
<213>  Homo Sapiens

<400>  4620

Met Lys Gln Tyr Ala Ser Pro Met Pro Thr Gln Thr Asp Val Lys Leu 
1               5                   10                  15      


Lys Phe Lys Pro Leu Ser Lys Lys Val Val Ser Ala Ala Leu Gln Phe 
            20                  25                  30          


Ser Leu Ser Cys Ile Phe Leu Arg Glu 
        35                  40      


<210>  4621
<211>  95
<212>  PRT
<213>  Homo Sapiens

<400>  4621

Met Lys Gln Tyr Ala Ser Pro Met Pro Thr Gln Thr Asp Val Lys Leu 
1               5                   10                  15      


Lys Phe Lys Pro Leu Ser Lys Lys Val Val Ser Ala Ala Leu Gln Phe 
            20                  25                  30          


Ser Leu Ser Cys Ile Phe Leu Arg Glu Gly Lys Ala Thr Asp Glu Asp 
        35                  40                  45              


Met Gln Ser Leu Ala Ser Leu Met Ser Met Lys Gln Ala Asp Ile Gly 
    50                  55                  60                  


Asn Leu Asp Asp Phe Glu Glu Asp Asn Glu Asp Asp Asp Glu Asn Arg 
65                  70                  75                  80  


Val Asn Gln Glu Glu Lys Ala Ala Lys Ile Thr Glu Ile Val Asn 
                85                  90                  95  


<210>  4622
<211>  108
<212>  PRT
<213>  Homo Sapiens

<400>  4622

Met Asn Trp Gln Pro Asp Lys Leu Val Val Val Trp Thr Arg Arg Ser 
1               5                   10                  15      


Arg Arg Lys Ser Ser Lys Ala His Ser Trp Gln Pro Gly Ile Lys Asn 
            20                  25                  30          


Pro Tyr Arg Gly Val Val Val Trp Pro Val Pro Glu Asn Ile Glu Ile 
        35                  40                  45              


Thr Val Thr Leu Phe Lys Asp Pro His Ala Glu Glu Phe Glu Asp Lys 
    50                  55                  60                  


Glu Trp Thr Phe Val Ile Glu Asn Glu Ser Pro Ser Gly Arg Arg Lys 
65                  70                  75                  80  


Ala Leu Ala Thr Ser Ser Ile Asn Met Lys Gln Tyr Ala Ser Pro Met 
                85                  90                  95      


Pro Thr Gln Thr Asp Val Lys Leu Lys Phe Lys Pro 
            100                 105             


<210>  4623
<211>  110
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4623

Xaa Leu Glu Lys Glu Lys Leu Glu Asn Ser Arg Ser Leu Glu Cys Arg 
1               5                   10                  15      


Ser Asp Pro Glu Ser Pro Ile Lys Lys Thr Ser Leu Ser Pro Thr Ser 
            20                  25                  30          


Lys Leu Gly Tyr Ser Tyr Ser Arg Asp Leu Asp Leu Ala Lys Lys Lys 
        35                  40                  45              


His Ala Ser Leu Arg Gln Thr Glu Ser Asp Pro Asp Ala Asp Arg Thr 
    50                  55                  60                  


Thr Leu Asn His Ala Asp His Ser Ser Lys Ile Val Gln Gln Gln Asp 
65                  70                  75                  80  


Glu Glu Arg Arg Arg Gln Leu Arg Glu Arg Ala Arg Gln Leu Ile Ala 
                85                  90                  95      


Glu Ala Arg Ser Gly Val Lys Met Ser Glu Leu Pro Ser Tyr 
            100                 105                 110 


<210>  4624
<211>  223
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4624

Xaa Asn Thr Asn Thr Ala Thr Pro Phe Cys Asn Arg Gln Leu Ser Asp 
1               5                   10                  15      


Gln Asp Glu Glu Arg Arg Arg Gln Leu Arg Glu Arg Ala Arg Gln Leu 
            20                  25                  30          


Ile Ala Glu Ala Arg Ser Gly Val Lys Met Ser Glu Leu Pro Ser Tyr 
        35                  40                  45              


Gly Glu Met Ala Ala Glu Lys Leu Lys Glu Arg Ser Lys Ala Ser Gly 
    50                  55                  60                  


Asp Glu Asn Asp Asn Ile Glu Ile Asp Thr Asn Glu Glu Ile Pro Glu 
65                  70                  75                  80  


Gly Phe Val Val Gly Gly Gly Asp Glu Leu Thr Asn Leu Glu Asn Asp 
                85                  90                  95      


Leu Asp Thr Pro Glu Gln Asn Ser Lys Leu Val Asp Leu Lys Leu Lys 
            100                 105                 110         


Lys Leu Leu Glu Val Gln Pro Gln Val Ala Asn Ser Pro Ser Ser Ala 
        115                 120                 125             


Ala Gln Lys Ala Val Thr Glu Ser Ser Glu Gln Asp Met Lys Ser Gly 
    130                 135                 140                 


Thr Glu Asp Leu Arg Thr Glu Arg Leu Gln Lys Thr Thr Glu Arg Phe 
145                 150                 155                 160 


Arg Asn Pro Val Val Phe Ser Lys Asp Ser Thr Val Arg Lys Thr Gln 
                165                 170                 175     


Leu Gln Ser Phe Ser Gln Tyr Ile Glu Asn Arg Pro Glu Met Lys Arg 
            180                 185                 190         


Gln Arg Ser Ile Gln Glu Asp Thr Lys Lys Gly Asn Glu Glu Lys Ala 
        195                 200                 205             


Ala Ile Thr Glu Thr Gln Arg Lys Pro Ser Glu Asp Glu Val Leu 
    210                 215                 220             


<210>  4625
<211>  154
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4625

Xaa Arg Leu Leu Glu Pro Ser Asp Met Thr Glu Ser Asp Pro Asp Ala 
1               5                   10                  15      


Asp Arg Thr Thr Leu Asn His Ala Asp His Ser Ser Lys Ile Val Gln 
            20                  25                  30          


His Arg Leu Leu Ser Arg Gln Glu Glu Leu Lys Glu Arg Ala Arg Val 
        35                  40                  45              


Leu Leu Glu Gln Ala Arg Arg Asp Ala Ala Leu Lys Ala Gly Asn Lys 
    50                  55                  60                  


His Asn Thr Asn Thr Ala Thr Pro Phe Cys Asn Arg Gln Leu Ser Asp 
65                  70                  75                  80  


Gln Gln Asp Glu Glu Arg Arg Arg Gln Leu Arg Glu Arg Ala Arg Gln 
                85                  90                  95      


Leu Ile Ala Glu Ala Arg Ser Gly Val Lys Met Ser Glu Leu Pro Ser 
            100                 105                 110         


Tyr Gly Glu Met Ala Ala Glu Lys Leu Lys Glu Arg Ser Lys Ala Ser 
        115                 120                 125             


Gly Asp Glu Asn Asp Asn Ile Glu Ile Asp Thr Asn Glu Glu Ile Pro 
    130                 135                 140                 


Glu Gly Phe Val Val Gly Gly Gly Asp Glu 
145                 150                 


<210>  4626
<211>  322
<212>  PRT
<213>  Homo Sapiens

<400>  4626

Met Gly Leu Pro Glu Arg Arg Gly Leu Val Leu Leu Leu Ser Leu Ala 
1               5                   10                  15      


Glu Ile Leu Phe Lys Ile Met Ile Leu Glu Gly Gly Gly Val Met Asn 
            20                  25                  30          


Leu Asn Pro Gly Asn Asn Leu Leu His Gln Pro Pro Ala Trp Thr Asp 
        35                  40                  45              


Ser Tyr Ser Thr Cys Asn Val Ser Ser Gly Phe Phe Gly Gly Gln Trp 
    50                  55                  60                  


His Glu Ile His Pro Gln Tyr Trp Thr Lys Tyr Gln Val Trp Glu Trp 
65                  70                  75                  80  


Leu Gln His Leu Leu Asp Thr Asn Gln Leu Asp Ala Asn Cys Ile Pro 
                85                  90                  95      


Phe Gln Glu Phe Asp Ile Asn Gly Glu His Leu Cys Ser Met Ser Leu 
            100                 105                 110         


Gln Glu Phe Thr Arg Ala Ala Gly Thr Ala Gly Gln Leu Leu Tyr Ser 
        115                 120                 125             


Asn Leu Gln His Leu Lys Trp Asn Gly Gln Cys Ser Ser Asp Leu Phe 
    130                 135                 140                 


Gln Ser Thr His Asn Val Ile Val Lys Thr Glu Gln Thr Glu Pro Ser 
145                 150                 155                 160 


Ile Met Asn Thr Trp Lys Asp Glu Asn Tyr Leu Tyr Asp Thr Asn Tyr 
                165                 170                 175     


Gly Ser Thr Val Asp Leu Leu Asp Ser Lys Thr Phe Cys Arg Ala Gln 
            180                 185                 190         


Ile Ser Met Thr Thr Thr Ser His Leu Pro Val Ala Glu Ser Pro Asp 
        195                 200                 205             


Met Lys Lys Glu Gln Asp Pro Pro Ala Lys Cys His Thr Lys Lys His 
    210                 215                 220                 


Asn Pro Arg Gly Thr His Leu Trp Glu Phe Ile Arg Asp Ile Leu Leu 
225                 230                 235                 240 


Asn Pro Asp Lys Asn Pro Gly Leu Ile Lys Trp Glu Asp Arg Ser Glu 
                245                 250                 255     


Gly Val Phe Arg Phe Leu Lys Ser Glu Ala Val Ala Gln Leu Trp Gly 
            260                 265                 270         


Lys Lys Lys Asn Asn Ser Ser Met Thr Tyr Glu Lys Leu Ser Arg Ala 
        275                 280                 285             


Met Arg Tyr Tyr Tyr Lys Arg Glu Ile Leu Glu Arg Val Asp Gly Arg 
    290                 295                 300                 


Arg Leu Val Tyr Lys Phe Gly Lys Asn Ala Arg Gly Trp Arg Glu Asn 
305                 310                 315                 320 


Glu Asn 
        


<210>  4627
<211>  126
<212>  PRT
<213>  Homo Sapiens

<400>  4627

Met Ile Leu Glu Gly Gly Gly Val Met Asn Leu Asn Pro Gly Asn Asn 
1               5                   10                  15      


Leu Leu His Gln Pro Pro Ala Trp Thr Asp Ser Tyr Ser Thr Cys Asn 
            20                  25                  30          


Val Ser Ser Gly Phe Phe Gly Gly Gln Trp His Glu Ile His Pro Gln 
        35                  40                  45              


Tyr Trp Thr Lys Tyr Gln Val Trp Glu Trp Leu Gln His Leu Leu Asp 
    50                  55                  60                  


Thr Asn Gln Leu Asp Ala Asn Cys Ile Pro Phe Gln Glu Phe Asp Ile 
65                  70                  75                  80  


Asn Gly Glu His Leu Cys Ser Met Ser Leu Gln Glu Phe Thr Arg Ala 
                85                  90                  95      


Ala Gly Thr Ala Gly Gln Leu Leu Tyr Ser Asn Leu Gln His Leu Lys 
            100                 105                 110         


Trp Asn Gly Asp Ser Leu Phe Leu Cys Leu Ser Leu Pro Cys 
        115                 120                 125     


<210>  4628
<211>  126
<212>  PRT
<213>  Homo Sapiens

<400>  4628

Met Ile Leu Glu Gly Gly Gly Val Met Asn Leu Asn Pro Gly Asn Asn 
1               5                   10                  15      


Leu Leu His Gln Pro Pro Ala Trp Thr Asp Ser Tyr Ser Thr Cys Asn 
            20                  25                  30          


Val Ser Ser Gly Phe Phe Gly Gly Gln Trp His Glu Ile His Pro Gln 
        35                  40                  45              


Tyr Trp Thr Lys Tyr Gln Val Trp Glu Trp Leu Gln His Leu Leu Asp 
    50                  55                  60                  


Thr Asn Gln Leu Asp Ala Asn Cys Ile Pro Phe Gln Glu Phe Asp Ile 
65                  70                  75                  80  


Asn Gly Glu His Leu Cys Ser Met Ser Leu Gln Glu Phe Thr Arg Ala 
                85                  90                  95      


Ala Gly Thr Ala Gly Gln Leu Leu Tyr Ser Asn Leu Gln His Leu Lys 
            100                 105                 110         


Trp Asn Gly Asp Ser Leu Phe Leu Cys Leu Ser Leu Pro Cys 
        115                 120                 125     


<210>  4629
<211>  158
<212>  PRT
<213>  Homo Sapiens

<400>  4629

Met Ile Leu Glu Gly Gly Gly Val Met Asn Leu Asn Pro Gly Asn Asn 
1               5                   10                  15      


Leu Leu His Gln Pro Pro Ala Trp Thr Asp Ser Tyr Ser Thr Cys Asn 
            20                  25                  30          


Val Ser Ser Gly Phe Phe Gly Gly Gln Trp His Glu Ile His Pro Gln 
        35                  40                  45              


Tyr Trp Thr Lys Tyr Gln Val Trp Glu Trp Leu Gln His Leu Leu Asp 
    50                  55                  60                  


Thr Asn Gln Leu Asp Ala Asn Cys Ile Pro Phe Gln Glu Phe Asp Ile 
65                  70                  75                  80  


Asn Gly Glu His Leu Cys Ser Met Ser Leu Gln Glu Phe Thr Arg Ala 
                85                  90                  95      


Ala Gly Thr Ala Gly Gln Leu Leu Tyr Ser Asn Leu Gln His Leu Lys 
            100                 105                 110         


Trp Asn Gly Gln Cys Ser Ser Asp Leu Phe Gln Ser Thr His Asn Val 
        115                 120                 125             


Ile Val Lys Thr Glu Gln Thr Glu Pro Ser Ile Met Asn Thr Trp Lys 
    130                 135                 140                 


Asp Glu Asn Tyr Leu Tyr Asp Thr Asn Tyr Gly Ser Thr Val 
145                 150                 155             


<210>  4630
<211>  166
<212>  PRT
<213>  Homo Sapiens

<400>  4630

Met Ile Leu Glu Gly Gly Gly Val Met Asn Leu Asn Pro Gly Asn Asn 
1               5                   10                  15      


Leu Leu His Gln Pro Pro Ala Trp Thr Asp Ser Tyr Ser Thr Cys Asn 
            20                  25                  30          


Val Ser Ser Gly Phe Phe Gly Gly Gln Trp His Glu Ile His Pro Gln 
        35                  40                  45              


Tyr Trp Thr Lys Tyr Gln Val Trp Glu Trp Leu Gln His Leu Leu Asp 
    50                  55                  60                  


Thr Asn Gln Leu Asp Ala Asn Cys Ile Pro Phe Gln Glu Phe Asp Ile 
65                  70                  75                  80  


Asn Gly Glu His Leu Cys Ser Met Ser Leu Gln Glu Phe Thr Arg Ala 
                85                  90                  95      


Ala Gly Thr Ala Gly Gln Leu Leu Tyr Ser Asn Leu Gln His Leu Lys 
            100                 105                 110         


Trp Asn Gly Gln Cys Ser Ser Asp Leu Phe Gln Ser Thr His Asn Val 
        115                 120                 125             


Ile Val Lys Thr Glu Gln Thr Glu Pro Ser Ile Met Asn Thr Trp Lys 
    130                 135                 140                 


Asp Glu Asn Tyr Leu Tyr Asp Thr Asn Tyr Gly Ser Thr Val Ala Glu 
145                 150                 155                 160 


Ser Pro Asp Met Lys Lys 
                165     


<210>  4631
<211>  277
<212>  PRT
<213>  Homo Sapiens

<400>  4631

Met Ile Leu Glu Gly Gly Gly Val Met Asn Leu Asn Pro Gly Asn Asn 
1               5                   10                  15      


Leu Leu His Gln Pro Pro Ala Trp Thr Asp Ser Tyr Ser Thr Cys Asn 
            20                  25                  30          


Val Ser Ser Gly Phe Phe Gly Gly Gln Trp His Glu Ile His Pro Gln 
        35                  40                  45              


Tyr Trp Thr Lys Tyr Gln Val Trp Glu Trp Leu Gln His Leu Leu Asp 
    50                  55                  60                  


Thr Asn Gln Leu Asp Ala Asn Cys Ile Pro Phe Gln Glu Phe Asp Ile 
65                  70                  75                  80  


Asn Gly Glu His Leu Cys Ser Met Ser Leu Gln Glu Phe Thr Arg Ala 
                85                  90                  95      


Ala Gly Thr Ala Gly Gln Leu Leu Tyr Ser Asn Leu Gln His Leu Lys 
            100                 105                 110         


Trp Asn Gly Gln Cys Ser Ser Asp Leu Phe Gln Ser Thr His Asn Val 
        115                 120                 125             


Ile Val Lys Thr Glu Gln Thr Glu Pro Ser Ile Met Asn Thr Trp Lys 
    130                 135                 140                 


Asp Glu Asn Tyr Leu Tyr Asp Thr Asn Tyr Gly Ser Thr Val Ala Glu 
145                 150                 155                 160 


Ser Pro Asp Met Lys Lys Glu Gln Asp Pro Pro Ala Lys Cys His Thr 
                165                 170                 175     


Lys Lys His Asn Pro Arg Gly Thr His Leu Trp Glu Phe Ile Arg Asp 
            180                 185                 190         


Ile Leu Leu Asn Pro Asp Lys Asn Pro Gly Leu Ile Lys Trp Glu Asp 
        195                 200                 205             


Arg Ser Glu Gly Val Phe Arg Phe Leu Lys Ser Glu Ala Val Ala Gln 
    210                 215                 220                 


Leu Trp Gly Lys Lys Lys Asn Asn Ser Ser Met Thr Tyr Glu Lys Leu 
225                 230                 235                 240 


Ser Arg Ala Met Arg Tyr Tyr Tyr Lys Arg Glu Ile Leu Glu Arg Val 
                245                 250                 255     


Asp Gly Arg Arg Leu Val Tyr Lys Phe Gly Lys Asn Ala Arg Gly Trp 
            260                 265                 270         


Arg Glu Asn Glu Asn 
        275         


<210>  4632
<211>  173
<212>  PRT
<213>  Homo Sapiens

<400>  4632

Met Ile Leu Glu Gly Gly Gly Val Met Asn Leu Asn Pro Gly Asn Asn 
1               5                   10                  15      


Leu Leu His Gln Pro Pro Ala Trp Thr Asp Ser Tyr Ser Thr Cys Asn 
            20                  25                  30          


Val Ser Ser Gly Phe Phe Gly Gly Gln Trp His Glu Ile His Pro Gln 
        35                  40                  45              


Tyr Trp Thr Lys Tyr Gln Val Trp Glu Trp Leu Gln His Leu Leu Asp 
    50                  55                  60                  


Thr Asn Gln Leu Asp Ala Asn Cys Ile Pro Phe Gln Glu Phe Asp Ile 
65                  70                  75                  80  


Asn Gly Glu His Leu Cys Ser Met Ser Leu Gln Glu Phe Thr Arg Ala 
                85                  90                  95      


Ala Gly Thr Ala Gly Gln Leu Leu Tyr Ser Asn Leu Gln His Leu Lys 
            100                 105                 110         


Trp Asn Gly Gln Cys Ser Ser Asp Leu Phe Gln Ser Thr His Asn Val 
        115                 120                 125             


Ile Val Lys Thr Glu Gln Thr Glu Pro Ser Ile Met Asn Thr Trp Lys 
    130                 135                 140                 


Asp Glu Asn Tyr Leu Tyr Asp Thr Asn Tyr Gly Ser Thr Val Asp Leu 
145                 150                 155                 160 


Leu Asp Ser Lys Thr Phe Cys Arg Ala Gln Ile Ser Met 
                165                 170             


<210>  4633
<211>  300
<212>  PRT
<213>  Homo Sapiens

<400>  4633

Met Ile Leu Glu Gly Gly Gly Val Met Asn Leu Asn Pro Gly Asn Asn 
1               5                   10                  15      


Leu Leu His Gln Pro Pro Ala Trp Thr Asp Ser Tyr Ser Thr Cys Asn 
            20                  25                  30          


Val Ser Ser Gly Phe Phe Gly Gly Gln Trp His Glu Ile His Pro Gln 
        35                  40                  45              


Tyr Trp Thr Lys Tyr Gln Val Trp Glu Trp Leu Gln His Leu Leu Asp 
    50                  55                  60                  


Thr Asn Gln Leu Asp Ala Asn Cys Ile Pro Phe Gln Glu Phe Asp Ile 
65                  70                  75                  80  


Asn Gly Glu His Leu Cys Ser Met Ser Leu Gln Glu Phe Thr Arg Ala 
                85                  90                  95      


Ala Gly Thr Ala Gly Gln Leu Leu Tyr Ser Asn Leu Gln His Leu Lys 
            100                 105                 110         


Trp Asn Gly Gln Cys Ser Ser Asp Leu Phe Gln Ser Thr His Asn Val 
        115                 120                 125             


Ile Val Lys Thr Glu Gln Thr Glu Pro Ser Ile Met Asn Thr Trp Lys 
    130                 135                 140                 


Asp Glu Asn Tyr Leu Tyr Asp Thr Asn Tyr Gly Ser Thr Val Asp Leu 
145                 150                 155                 160 


Leu Asp Ser Lys Thr Phe Cys Arg Ala Gln Ile Ser Met Thr Thr Thr 
                165                 170                 175     


Ser His Leu Pro Val Ala Glu Ser Pro Asp Met Lys Lys Glu Gln Asp 
            180                 185                 190         


Pro Pro Ala Lys Cys His Thr Lys Lys His Asn Pro Arg Gly Thr His 
        195                 200                 205             


Leu Trp Glu Phe Ile Arg Asp Ile Leu Leu Asn Pro Asp Lys Asn Pro 
    210                 215                 220                 


Gly Leu Ile Lys Trp Glu Asp Arg Ser Glu Gly Val Phe Arg Phe Leu 
225                 230                 235                 240 


Lys Ser Glu Ala Val Ala Gln Leu Trp Gly Lys Lys Lys Asn Asn Ser 
                245                 250                 255     


Ser Met Thr Tyr Glu Lys Leu Ser Arg Ala Met Arg Tyr Tyr Tyr Lys 
            260                 265                 270         


Arg Glu Ile Leu Glu Arg Val Asp Gly Arg Arg Leu Val Tyr Lys Phe 
        275                 280                 285             


Gly Lys Asn Ala Arg Gly Trp Arg Glu Asn Glu Asn 
    290                 295                 300 


<210>  4634
<211>  300
<212>  PRT
<213>  Homo Sapiens

<400>  4634

Met Ile Leu Glu Gly Gly Gly Val Met Asn Leu Asn Pro Gly Asn Asn 
1               5                   10                  15      


Leu Leu His Gln Pro Pro Ala Trp Thr Asp Ser Tyr Ser Thr Cys Asn 
            20                  25                  30          


Val Ser Ser Gly Phe Phe Gly Gly Gln Trp His Glu Ile His Pro Gln 
        35                  40                  45              


Tyr Trp Thr Lys Tyr Gln Val Trp Glu Trp Leu Gln His Leu Leu Asp 
    50                  55                  60                  


Thr Asn Gln Leu Asp Ala Asn Cys Ile Pro Phe Gln Glu Phe Asp Ile 
65                  70                  75                  80  


Asn Gly Glu His Leu Cys Ser Met Ser Leu Gln Glu Phe Thr Arg Ala 
                85                  90                  95      


Ala Gly Thr Ala Gly Gln Leu Leu Tyr Ser Asn Leu Gln His Leu Lys 
            100                 105                 110         


Trp Asn Gly Gln Cys Ser Ser Asp Leu Phe Gln Ser Thr His Asn Val 
        115                 120                 125             


Ile Val Lys Thr Glu Gln Thr Glu Pro Ser Ile Met Asn Thr Trp Lys 
    130                 135                 140                 


Asp Glu Asn Tyr Leu Tyr Asp Thr Asn Tyr Gly Ser Thr Val Asp Leu 
145                 150                 155                 160 


Leu Asp Ser Lys Thr Phe Cys Arg Ala Gln Ile Ser Met Thr Thr Thr 
                165                 170                 175     


Ser His Leu Pro Val Ala Glu Ser Pro Asp Met Lys Lys Glu Gln Asp 
            180                 185                 190         


Pro Pro Ala Lys Cys His Thr Lys Lys His Asn Pro Arg Gly Thr His 
        195                 200                 205             


Leu Trp Glu Phe Ile Arg Asp Ile Leu Leu Asn Pro Asp Lys Asn Pro 
    210                 215                 220                 


Gly Leu Ile Lys Trp Glu Asp Arg Ser Glu Gly Val Phe Arg Phe Leu 
225                 230                 235                 240 


Lys Ser Glu Ala Val Ala Gln Leu Trp Gly Lys Lys Lys Asn Asn Ser 
                245                 250                 255     


Ser Met Thr Tyr Glu Lys Leu Ser Arg Ala Met Arg Tyr Tyr Tyr Lys 
            260                 265                 270         


Arg Glu Ile Leu Glu Arg Val Asp Gly Arg Arg Leu Val Tyr Lys Phe 
        275                 280                 285             


Gly Lys Asn Ala Arg Gly Trp Arg Glu Asn Glu Asn 
    290                 295                 300 


<210>  4635
<211>  300
<212>  PRT
<213>  Homo Sapiens

<400>  4635

Met Ile Leu Glu Gly Gly Gly Val Met Asn Leu Asn Pro Gly Asn Asn 
1               5                   10                  15      


Leu Leu His Gln Pro Pro Ala Trp Thr Asp Ser Tyr Ser Thr Cys Asn 
            20                  25                  30          


Val Ser Ser Gly Phe Phe Gly Gly Gln Trp His Glu Ile His Pro Gln 
        35                  40                  45              


Tyr Trp Thr Lys Tyr Gln Val Trp Glu Trp Leu Gln His Leu Leu Asp 
    50                  55                  60                  


Thr Asn Gln Leu Asp Ala Asn Cys Ile Pro Phe Gln Glu Phe Asp Ile 
65                  70                  75                  80  


Asn Gly Glu His Leu Cys Ser Met Ser Leu Gln Glu Phe Thr Arg Ala 
                85                  90                  95      


Ala Gly Thr Ala Gly Gln Leu Leu Tyr Ser Asn Leu Gln His Leu Lys 
            100                 105                 110         


Trp Asn Gly Gln Cys Ser Ser Asp Leu Phe Gln Ser Thr His Asn Val 
        115                 120                 125             


Ile Val Lys Thr Glu Gln Thr Glu Pro Ser Ile Met Asn Thr Trp Lys 
    130                 135                 140                 


Asp Glu Asn Tyr Leu Tyr Asp Thr Asn Tyr Gly Ser Thr Val Asp Leu 
145                 150                 155                 160 


Leu Asp Ser Lys Thr Phe Cys Arg Ala Gln Ile Ser Met Thr Thr Thr 
                165                 170                 175     


Ser His Leu Pro Val Ala Glu Ser Pro Asp Met Lys Lys Glu Gln Asp 
            180                 185                 190         


Pro Pro Ala Lys Cys His Thr Lys Lys His Asn Pro Arg Gly Thr His 
        195                 200                 205             


Leu Trp Glu Phe Ile Arg Asp Ile Leu Leu Asn Pro Asp Lys Asn Pro 
    210                 215                 220                 


Gly Leu Ile Lys Trp Glu Asp Arg Ser Glu Gly Val Phe Arg Phe Leu 
225                 230                 235                 240 


Lys Ser Glu Ala Val Ala Gln Leu Trp Gly Lys Lys Lys Asn Asn Ser 
                245                 250                 255     


Ser Met Thr Tyr Glu Lys Leu Ser Arg Ala Met Arg Tyr Tyr Tyr Lys 
            260                 265                 270         


Arg Glu Ile Leu Glu Arg Val Asp Gly Arg Arg Leu Val Tyr Lys Phe 
        275                 280                 285             


Gly Lys Asn Ala Arg Gly Trp Arg Glu Asn Glu Asn 
    290                 295                 300 


<210>  4636
<211>  370
<212>  PRT
<213>  Homo Sapiens

<400>  4636

Gly Leu Gly Arg Pro Thr Pro Gly Leu Ser Gln Gly Pro Gly Lys Glu 
1               5                   10                  15      


Thr Leu Glu Ser Ala Leu Ile Ala Leu Asp Ser Glu Lys Pro Lys Lys 
            20                  25                  30          


Leu Arg Phe His Pro Lys Gln Leu Tyr Phe Ser Ala Arg Gln Gly Glu 
        35                  40                  45              


Leu Gln Lys Val Leu Leu Met Leu Val Asp Gly Ile Asp Pro Asn Phe 
    50                  55                  60                  


Lys Met Glu His Gln Asn Lys Arg Ser Pro Leu His Ala Ala Ala Glu 
65                  70                  75                  80  


Ala Gly His Val Asp Ile Cys His Met Leu Val Gln Ala Gly Ala Asn 
                85                  90                  95      


Ile Asp Thr Cys Ser Glu Asp Gln Arg Thr Pro Leu Met Glu Ala Ala 
            100                 105                 110         


Glu Asn Asn His Leu Glu Ala Val Lys Tyr Leu Ile Lys Ala Gly Ala 
        115                 120                 125             


Leu Val Asp Pro Lys Asp Ala Glu Gly Ser Thr Cys Leu His Leu Ala 
    130                 135                 140                 


Ala Lys Lys Gly His Tyr Glu Val Val Gln Tyr Leu Leu Ser Asn Gly 
145                 150                 155                 160 


Gln Met Asp Val Asn Cys Gln Asp Asp Gly Gly Trp Thr Pro Met Ile 
                165                 170                 175     


Trp Ala Thr Glu Tyr Lys His Val Asp Leu Val Lys Leu Leu Leu Ser 
            180                 185                 190         


Lys Gly Ser Asp Ile Asn Ile Arg Asp Asn Glu Glu Asn Ile Cys Leu 
        195                 200                 205             


His Trp Ala Ala Phe Ser Gly Cys Val Asp Ile Ala Glu Ile Leu Leu 
    210                 215                 220                 


Ala Ala Lys Cys Asp Leu His Ala Val Asn Ile His Gly Asp Ser Pro 
225                 230                 235                 240 


Leu His Ile Ala Ala Arg Glu Asn Arg Tyr Asp Cys Val Val Leu Phe 
                245                 250                 255     


Leu Ser Arg Asp Ser Asp Val Thr Leu Lys Asn Lys Glu Gly Glu Thr 
            260                 265                 270         


Pro Leu Gln Cys Ala Ser Leu Asn Ser Gln Val Trp Ser Ala Leu Gln 
        275                 280                 285             


Met Ser Lys Ala Leu Gln Asp Ser Ala Pro Asp Arg Pro Ser Pro Val 
    290                 295                 300                 


Glu Arg Ile Val Ser Arg Asp Ile Ala Arg Gly Tyr Glu Arg Ile Pro 
305                 310                 315                 320 


Ile Pro Cys Val Asn Ala Val Asp Ser Glu Pro Cys Pro Ser Asn Tyr 
                325                 330                 335     


Lys Tyr Val Ser Gln Asn Cys Val Thr Ser Pro Met Asn Ile Asp Arg 
            340                 345                 350         


Asn Ile Thr His Leu Gln Ala Leu Asp Met Phe Leu Pro Ala Gln Pro 
        355                 360                 365             


Ser Pro 
    370 


<210>  4637
<211>  1298
<212>  PRT
<213>  Homo Sapiens

<400>  4637

Met Ala Ala Ala Asp Ala Glu Ala Val Pro Ala Arg Gly Glu Pro Gln 
1               5                   10                  15      


Gln Asp Cys Cys Val Lys Thr Glu Leu Leu Gly Glu Glu Thr Pro Met 
            20                  25                  30          


Ala Ala Asp Glu Gly Ser Ala Glu Lys Gln Ala Gly Glu Ala His Met 
        35                  40                  45              


Ala Ala Asp Gly Glu Thr Asn Gly Ser Cys Glu Asn Ser Asp Ala Ser 
    50                  55                  60                  


Ser His Ala Asn Ala Ala Lys His Thr Gln Asp Ser Ala Arg Val Asn 
65                  70                  75                  80  


Pro Gln Asp Gly Thr Asn Thr Leu Thr Arg Ile Ala Glu Asn Gly Val 
                85                  90                  95      


Ser Glu Arg Asp Ser Glu Ala Ala Lys Gln Asn His Val Thr Ala Asp 
            100                 105                 110         


Asp Phe Val Gln Thr Ser Val Ile Gly Ser Asn Gly Tyr Ile Leu Asn 
        115                 120                 125             


Lys Pro Ala Leu Gln Ala Gln Pro Leu Arg Thr Thr Ser Thr Leu Ala 
    130                 135                 140                 


Ser Ser Leu Pro Gly His Ala Ala Lys Thr Leu Pro Gly Gly Ala Gly 
145                 150                 155                 160 


Lys Gly Arg Thr Pro Ser Ala Phe Pro Gln Thr Pro Ala Ala Pro Pro 
                165                 170                 175     


Ala Thr Leu Gly Glu Gly Ser Ala Asp Thr Glu Asp Arg Lys Leu Pro 
            180                 185                 190         


Ala Pro Gly Ala Asp Val Lys Val His Arg Ala Arg Lys Thr Met Pro 
        195                 200                 205             


Lys Ser Val Val Gly Leu His Ala Ala Ser Lys Asp Pro Arg Glu Val 
    210                 215                 220                 


Arg Glu Ala Arg Asp His Lys Glu Pro Lys Glu Glu Ile Asn Lys Asn 
225                 230                 235                 240 


Ile Ser Asp Phe Gly Arg Gln Gln Leu Leu Pro Pro Phe Pro Ser Leu 
                245                 250                 255     


His Gln Ser Leu Pro Gln Asn Gln Cys Tyr Met Ala Thr Thr Lys Ser 
            260                 265                 270         


Gln Thr Ala Cys Leu Pro Phe Val Leu Ala Ala Ala Val Ser Arg Lys 
        275                 280                 285             


Lys Lys Arg Arg Met Gly Thr Tyr Ser Leu Val Pro Lys Lys Lys Thr 
    290                 295                 300                 


Lys Val Leu Lys Gln Arg Thr Val Ile Glu Met Phe Lys Ser Ile Thr 
305                 310                 315                 320 


His Ser Thr Val Gly Ser Lys Gly Glu Lys Asp Leu Gly Ala Ser Ser 
                325                 330                 335     


Leu His Val Asn Gly Glu Ser Leu Glu Met Asp Ser Asp Glu Asp Asp 
            340                 345                 350         


Ser Glu Glu Leu Glu Glu Asp Asp Gly His Gly Ala Glu Gln Ala Ala 
        355                 360                 365             


Ala Phe Pro Thr Glu Asp Ser Arg Thr Ser Lys Glu Ser Met Ser Glu 
    370                 375                 380                 


Ala Asp Arg Ala Gln Lys Met Asp Gly Glu Ser Glu Glu Glu Gln Glu 
385                 390                 395                 400 


Ser Val Asp Thr Gly Glu Glu Glu Glu Gly Gly Asp Glu Ser Asp Leu 
                405                 410                 415     


Ser Ser Glu Ser Ser Ile Lys Lys Lys Phe Leu Lys Arg Lys Gly Lys 
            420                 425                 430         


Thr Asp Ser Pro Trp Ile Lys Pro Ala Arg Lys Arg Arg Arg Arg Ser 
        435                 440                 445             


Arg Lys Lys Pro Ser Gly Ala Leu Gly Ser Glu Ser Tyr Lys Ser Ser 
    450                 455                 460                 


Ala Gly Ser Ala Glu Gln Thr Ala Pro Gly Asp Ser Thr Gly Tyr Met 
465                 470                 475                 480 


Glu Val Ser Leu Asp Ser Leu Asp Leu Arg Val Lys Gly Ile Leu Ser 
                485                 490                 495     


Ser Gln Ala Glu Gly Leu Ala Asn Gly Pro Asp Val Leu Glu Thr Asp 
            500                 505                 510         


Gly Leu Gln Glu Val Pro Leu Cys Ser Cys Arg Met Glu Thr Pro Lys 
        515                 520                 525             


Ser Arg Glu Ile Thr Thr Leu Ala Asn Asn Gln Cys Met Ala Thr Glu 
    530                 535                 540                 


Ser Val Asp His Glu Leu Gly Arg Cys Thr Asn Ser Val Val Lys Tyr 
545                 550                 555                 560 


Glu Leu Met Arg Pro Ser Asn Lys Ala Pro Leu Leu Val Leu Cys Glu 
                565                 570                 575     


Asp His Arg Gly Arg Met Val Lys His Gln Cys Cys Pro Gly Cys Gly 
            580                 585                 590         


Tyr Phe Cys Thr Ala Gly Asn Phe Met Glu Cys Gln Pro Glu Ser Ser 
        595                 600                 605             


Ile Ser His Arg Phe His Lys Asp Cys Ala Ser Arg Val Asn Asn Ala 
    610                 615                 620                 


Ser Tyr Cys Pro His Cys Gly Glu Glu Ser Ser Lys Ala Lys Glu Val 
625                 630                 635                 640 


Thr Ile Ala Lys Ala Asp Thr Thr Ser Thr Val Thr Pro Val Pro Gly 
                645                 650                 655     


Gln Glu Lys Gly Ser Ala Leu Glu Gly Arg Ala Asp Thr Thr Thr Gly 
            660                 665                 670         


Ser Ala Ala Gly Pro Pro Leu Ser Glu Asp Asp Lys Leu Gln Gly Ala 
        675                 680                 685             


Ala Ser His Val Pro Glu Gly Phe Asp Pro Thr Gly Pro Ala Gly Leu 
    690                 695                 700                 


Gly Arg Pro Thr Pro Gly Leu Ser Gln Gly Pro Gly Lys Glu Thr Leu 
705                 710                 715                 720 


Glu Ser Ala Leu Ile Ala Leu Asp Ser Glu Lys Pro Lys Lys Leu Arg 
                725                 730                 735     


Phe His Pro Lys Gln Leu Tyr Phe Ser Ala Arg Gln Gly Glu Leu Gln 
            740                 745                 750         


Lys Val Leu Leu Met Leu Val Asp Gly Ile Asp Pro Asn Phe Lys Met 
        755                 760                 765             


Glu His Gln Asn Lys Arg Ser Pro Leu His Ala Ala Ala Glu Ala Gly 
    770                 775                 780                 


His Val Asp Ile Cys His Met Leu Val Gln Ala Gly Ala Asn Ile Asp 
785                 790                 795                 800 


Thr Cys Ser Glu Asp Gln Arg Thr Pro Leu Met Glu Ala Ala Glu Asn 
                805                 810                 815     


Asn His Leu Glu Ala Val Lys Tyr Leu Ile Lys Ala Gly Ala Leu Val 
            820                 825                 830         


Asp Pro Lys Asp Ala Glu Gly Ser Thr Cys Leu His Leu Ala Ala Lys 
        835                 840                 845             


Lys Gly His Tyr Glu Val Val Gln Tyr Leu Leu Ser Asn Gly Gln Met 
    850                 855                 860                 


Asp Val Asn Cys Gln Asp Asp Gly Gly Trp Thr Pro Met Ile Trp Ala 
865                 870                 875                 880 


Thr Glu Tyr Lys His Val Asp Leu Val Lys Leu Leu Leu Ser Lys Gly 
                885                 890                 895     


Ser Asp Ile Asn Ile Arg Asp Asn Glu Glu Asn Ile Cys Leu His Trp 
            900                 905                 910         


Ala Ala Phe Ser Gly Cys Val Asp Ile Ala Glu Ile Leu Leu Ala Ala 
        915                 920                 925             


Lys Cys Asp Leu His Ala Val Asn Ile His Gly Asp Ser Pro Leu His 
    930                 935                 940                 


Ile Ala Ala Arg Glu Asn Arg Tyr Asp Cys Val Val Leu Phe Leu Ser 
945                 950                 955                 960 


Arg Asp Ser Asp Val Thr Leu Lys Asn Lys Glu Gly Glu Thr Pro Leu 
                965                 970                 975     


Gln Cys Ala Ser Leu Asn Ser Gln Val Trp Ser Ala Leu Gln Met Ser 
            980                 985                 990         


Lys Ala Leu Gln Asp Ser Ala Pro  Asp Arg Pro Ser Pro  Val Glu Arg 
        995                 1000                 1005             


Ile Val  Ser Arg Asp Ile Ala  Arg Gly Tyr Glu Arg  Ile Pro Ile 
    1010                 1015                 1020             


Pro Cys  Val Asn Ala Val Asp  Ser Glu Pro Cys Pro  Ser Asn Tyr 
    1025                 1030                 1035             


Lys Tyr  Val Ser Gln Asn Cys  Val Thr Ser Pro Met  Asn Ile Asp 
    1040                 1045                 1050             


Arg Asn  Ile Thr His Leu Gln  Tyr Cys Val Cys Ile  Asp Asp Cys 
    1055                 1060                 1065             


Ser Ser  Ser Asn Cys Met Cys  Gly Gln Leu Ser Met  Arg Cys Trp 
    1070                 1075                 1080             


Tyr Asp  Lys Asp Gly Arg Leu  Leu Pro Glu Phe Asn  Met Ala Glu 
    1085                 1090                 1095             


Pro Pro  Leu Ile Phe Glu Cys  Asn His Ala Cys Ser  Cys Trp Arg 
    1100                 1105                 1110             


Asn Cys  Arg Asn Arg Val Val  Gln Asn Gly Leu Arg  Ala Arg Leu 
    1115                 1120                 1125             


Gln Leu  Tyr Arg Thr Arg Asp  Met Gly Trp Gly Val  Arg Ser Leu 
    1130                 1135                 1140             


Gln Asp  Ile Pro Pro Gly Thr  Phe Val Cys Glu Tyr  Val Gly Glu 
    1145                 1150                 1155             


Leu Ile  Ser Asp Ser Glu Ala  Asp Val Arg Glu Glu  Asp Ser Tyr 
    1160                 1165                 1170             


Leu Phe  Asp Leu Asp Asn Lys  Asp Gly Glu Val Tyr  Cys Ile Asp 
    1175                 1180                 1185             


Ala Arg  Phe Tyr Gly Asn Val  Ser Arg Phe Ile Asn  His His Cys 
    1190                 1195                 1200             


Glu Pro  Asn Leu Val Pro Val  Arg Val Phe Met Ala  His Gln Asp 
    1205                 1210                 1215             


Leu Arg  Phe Pro Arg Ile Ala  Phe Phe Ser Thr Arg  Leu Ile Glu 
    1220                 1225                 1230             


Ala Gly  Glu Gln Leu Gly Phe  Asp Tyr Gly Glu Arg  Phe Trp Asp 
    1235                 1240                 1245             


Ile Lys  Gly Lys Leu Phe Ser  Cys Arg Cys Gly Ser  Pro Lys Cys 
    1250                 1255                 1260             


Arg His  Ser Ser Ala Ala Leu  Ala Gln Arg Gln Ala  Ser Ala Ala 
    1265                 1270                 1275             


Gln Glu  Ala Gln Glu Asp Gly  Leu Pro Asp Thr Ser  Ser Ala Ala 
    1280                 1285                 1290             


Ala Ala  Asp Pro Leu 
    1295             


<210>  4638
<211>  808
<212>  PRT
<213>  Homo Sapiens

<400>  4638

Met Ala Ala Ala Asp Ala Glu Ala Val Pro Ala Arg Gly Glu Pro Gln 
1               5                   10                  15      


Gln Asp Cys Cys Val Lys Thr Glu Leu Leu Gly Glu Glu Thr Pro Met 
            20                  25                  30          


Ala Ala Asp Glu Gly Ser Ala Glu Lys Gln Ala Gly Glu Ala His Met 
        35                  40                  45              


Ala Ala Asp Gly Glu Thr Asn Gly Ser Cys Glu Asn Ser Asp Ala Ser 
    50                  55                  60                  


Ser His Ala Asn Ala Ala Lys His Thr Gln Asp Ser Ala Arg Val Asn 
65                  70                  75                  80  


Pro Gln Asp Gly Thr Asn Thr Leu Thr Arg Ile Ala Glu Asn Gly Val 
                85                  90                  95      


Ser Glu Arg Asp Ser Glu Ala Ala Lys Gln Asn His Val Thr Ala Asp 
            100                 105                 110         


Asp Phe Val Gln Thr Ser Val Ile Gly Ser Asn Gly Tyr Ile Leu Asn 
        115                 120                 125             


Lys Pro Ala Leu Gln Ala Gln Pro Leu Arg Thr Thr Ser Thr Leu Ala 
    130                 135                 140                 


Ser Ser Leu Pro Gly His Ala Ala Lys Thr Leu Pro Gly Gly Ala Gly 
145                 150                 155                 160 


Lys Gly Arg Thr Pro Ser Ala Phe Pro Gln Thr Pro Ala Ala Pro Pro 
                165                 170                 175     


Ala Thr Leu Gly Glu Gly Ser Ala Asp Thr Glu Asp Arg Lys Leu Pro 
            180                 185                 190         


Ala Pro Gly Ala Asp Val Lys Val His Arg Ala Arg Lys Thr Met Pro 
        195                 200                 205             


Lys Ser Val Val Gly Leu His Ala Ala Ser Lys Asp Pro Arg Glu Val 
    210                 215                 220                 


Arg Glu Ala Arg Asp His Lys Glu Pro Lys Glu Glu Ile Asn Lys Asn 
225                 230                 235                 240 


Ile Ser Asp Phe Gly Arg Gln Gln Leu Leu Pro Pro Phe Pro Ser Leu 
                245                 250                 255     


His Gln Ser Leu Pro Gln Asn Gln Cys Tyr Met Ala Thr Thr Lys Ser 
            260                 265                 270         


Gln Thr Ala Cys Leu Pro Phe Val Leu Ala Ala Ala Val Ser Arg Lys 
        275                 280                 285             


Lys Lys Arg Arg Met Gly Thr Tyr Ser Leu Val Pro Lys Lys Lys Thr 
    290                 295                 300                 


Lys Val Leu Lys Gln Arg Thr Val Ile Glu Met Phe Lys Ser Ile Thr 
305                 310                 315                 320 


His Ser Thr Val Gly Ser Lys Gly Glu Lys Asp Leu Gly Ala Ser Ser 
                325                 330                 335     


Leu His Val Asn Gly Glu Ser Leu Glu Met Asp Ser Asp Glu Asp Asp 
            340                 345                 350         


Ser Glu Glu Leu Glu Glu Asp Asp Gly His Gly Ala Glu Gln Ala Ala 
        355                 360                 365             


Ala Phe Pro Thr Glu Asp Ser Arg Thr Ser Lys Glu Ser Met Ser Glu 
    370                 375                 380                 


Ala Asp Arg Ala Gln Lys Met Asp Gly Glu Ser Glu Glu Glu Gln Glu 
385                 390                 395                 400 


Ser Val Asp Thr Gly Glu Glu Glu Glu Gly Gly Asp Glu Ser Asp Leu 
                405                 410                 415     


Ser Ser Glu Ser Ser Ile Lys Lys Lys Phe Leu Lys Arg Lys Gly Lys 
            420                 425                 430         


Thr Asp Ser Pro Trp Ile Lys Pro Ala Arg Lys Arg Arg Arg Arg Ser 
        435                 440                 445             


Arg Lys Lys Pro Ser Gly Ala Leu Gly Ser Glu Ser Tyr Lys Ser Ser 
    450                 455                 460                 


Ala Gly Ser Ala Glu Gln Thr Ala Pro Gly Asp Ser Thr Gly Tyr Met 
465                 470                 475                 480 


Glu Val Ser Leu Asp Ser Leu Asp Leu Arg Val Lys Gly Ile Leu Ser 
                485                 490                 495     


Ser Gln Ala Glu Gly Leu Ala Asn Gly Pro Asp Val Leu Glu Thr Asp 
            500                 505                 510         


Gly Leu Gln Glu Val Pro Leu Cys Ser Cys Arg Met Glu Thr Pro Lys 
        515                 520                 525             


Ser Arg Glu Ile Thr Thr Leu Ala Asn Asn Gln Cys Met Ala Thr Glu 
    530                 535                 540                 


Ser Val Asp His Glu Leu Gly Arg Cys Thr Asn Ser Val Val Lys Tyr 
545                 550                 555                 560 


Glu Leu Met Arg Pro Ser Asn Lys Ala Pro Leu Leu Val Leu Cys Glu 
                565                 570                 575     


Asp His Arg Gly Arg Met Val Lys His Gln Cys Cys Pro Gly Cys Gly 
            580                 585                 590         


Tyr Phe Cys Thr Ala Gly Asn Phe Met Glu Cys Gln Pro Glu Ser Ser 
        595                 600                 605             


Ile Ser His Arg Phe His Lys Asp Cys Ala Ser Arg Val Asn Asn Ala 
    610                 615                 620                 


Ser Tyr Cys Pro His Cys Gly Glu Glu Ser Ser Lys Ala Lys Glu Val 
625                 630                 635                 640 


Thr Ile Ala Lys Ala Asp Thr Thr Ser Thr Val Thr Pro Val Pro Gly 
                645                 650                 655     


Gln Glu Lys Gly Ser Ala Leu Glu Gly Arg Ala Asp Thr Thr Thr Gly 
            660                 665                 670         


Ser Ala Ala Gly Pro Pro Leu Ser Glu Asp Asp Lys Leu Gln Gly Ala 
        675                 680                 685             


Ala Ser His Val Pro Glu Gly Phe Asp Pro Thr Gly Pro Ala Gly Leu 
    690                 695                 700                 


Gly Arg Pro Thr Pro Gly Leu Ser Gln Gly Pro Gly Lys Glu Thr Leu 
705                 710                 715                 720 


Glu Ser Ala Leu Ile Ala Leu Asp Ser Glu Lys Pro Lys Lys Leu Arg 
                725                 730                 735     


Phe His Pro Lys Gln Leu Tyr Phe Ser Ala Arg Gln Gly Glu Leu Gln 
            740                 745                 750         


Lys Val Leu Leu Met Leu Val Asp Gly Ile Asp Pro Asn Phe Lys Met 
        755                 760                 765             


Glu His Gln Asn Lys Arg Ser Pro Leu His Ala Ala Ala Glu Ala Gly 
    770                 775                 780                 


His Val Asp Ile Cys His Met Leu Val Gln Phe Cys Arg Leu Gly Ser 
785                 790                 795                 800 


Pro Arg Ser Arg Gly Cys Leu Trp 
                805             


<210>  4639
<211>  556
<212>  PRT
<213>  Homo Sapiens

<400>  4639

Met Ala Ala Ala Asp Ala Glu Ala Val Pro Ala Arg Gly Glu Pro Gln 
1               5                   10                  15      


Gln Asp Cys Cys Val Lys Thr Glu Leu Leu Gly Glu Glu Thr Pro Met 
            20                  25                  30          


Ala Ala Asp Glu Gly Ser Ala Glu Lys Gln Ala Gly Glu Ala His Met 
        35                  40                  45              


Ala Ala Asp Gly Glu Thr Asn Gly Ser Cys Glu Asn Ser Asp Ala Ser 
    50                  55                  60                  


Ser His Ala Asn Ala Ala Lys His Thr Gln Asp Ser Ala Arg Val Asn 
65                  70                  75                  80  


Pro Gln Asp Gly Thr Asn Thr Leu Thr Arg Ile Ala Glu Asn Gly Val 
                85                  90                  95      


Ser Glu Arg Asp Ser Glu Ala Ala Lys Gln Asn His Val Thr Ala Asp 
            100                 105                 110         


Asp Phe Val Gln Thr Ser Val Ile Gly Ser Asn Gly Tyr Ile Leu Asn 
        115                 120                 125             


Lys Pro Ala Leu Gln Ala Gln Pro Leu Arg Thr Thr Ser Thr Leu Ala 
    130                 135                 140                 


Ser Ser Leu Pro Gly His Ala Ala Lys Thr Leu Pro Gly Gly Ala Gly 
145                 150                 155                 160 


Lys Gly Arg Thr Pro Ser Ala Phe Pro Gln Thr Pro Ala Ala Pro Pro 
                165                 170                 175     


Ala Thr Leu Gly Glu Gly Ser Ala Asp Thr Glu Asp Arg Lys Leu Pro 
            180                 185                 190         


Ala Pro Gly Ala Asp Val Lys Val His Arg Ala Arg Lys Thr Met Pro 
        195                 200                 205             


Lys Ser Val Val Gly Leu His Ala Ala Ser Lys Asp Pro Arg Glu Val 
    210                 215                 220                 


Arg Glu Ala Arg Asp His Lys Glu Pro Lys Glu Glu Ile Asn Lys Asn 
225                 230                 235                 240 


Ile Ser Asp Phe Gly Arg Gln Gln Leu Leu Pro Pro Phe Pro Ser Leu 
                245                 250                 255     


His Gln Ser Leu Pro Gln Asn Gln Cys Tyr Met Ala Thr Thr Lys Ser 
            260                 265                 270         


Gln Thr Ala Cys Leu Pro Phe Val Leu Ala Ala Ala Val Ser Arg Lys 
        275                 280                 285             


Lys Lys Arg Arg Met Gly Thr Tyr Ser Leu Val Pro Lys Lys Lys Thr 
    290                 295                 300                 


Lys Val Leu Lys Gln Arg Thr Val Ile Glu Met Phe Lys Ser Ile Thr 
305                 310                 315                 320 


His Ser Thr Val Gly Ser Lys Gly Glu Lys Asp Leu Gly Ala Ser Ser 
                325                 330                 335     


Leu His Val Asn Gly Glu Ser Leu Glu Met Asp Ser Asp Glu Asp Asp 
            340                 345                 350         


Ser Glu Glu Leu Glu Glu Asp Asp Gly His Gly Ala Glu Gln Ala Ala 
        355                 360                 365             


Ala Phe Pro Thr Glu Asp Ser Arg Thr Ser Lys Glu Ser Met Ser Glu 
    370                 375                 380                 


Ala Asp Arg Ala Gln Lys Met Asp Gly Glu Ser Glu Glu Glu Gln Glu 
385                 390                 395                 400 


Ser Val Asp Thr Gly Glu Glu Glu Glu Gly Gly Asp Glu Ser Asp Leu 
                405                 410                 415     


Ser Ser Glu Ser Ser Ile Lys Lys Lys Phe Leu Lys Arg Lys Gly Lys 
            420                 425                 430         


Thr Asp Ser Pro Trp Ile Lys Pro Ala Arg Lys Arg Arg Arg Arg Ser 
        435                 440                 445             


Arg Lys Lys Pro Ser Gly Ala Leu Gly Ser Glu Ser Tyr Lys Ser Ser 
    450                 455                 460                 


Ala Gly Ser Ala Glu Gln Thr Ala Pro Gly Asp Ser Thr Gly Tyr Met 
465                 470                 475                 480 


Glu Val Ser Leu Asp Ser Leu Asp Leu Arg Val Lys Gly Ile Leu Ser 
                485                 490                 495     


Ser Gln Ala Glu Gly Leu Ala Asn Gly Pro Asp Val Leu Glu Thr Asp 
            500                 505                 510         


Gly Leu Gln Glu Val Pro Leu Cys Ser Cys Arg Met Glu Thr Pro Lys 
        515                 520                 525             


Ser Arg Glu Ile Thr Thr Leu Ala Asn Asn Gln Cys Met Ala Thr Glu 
    530                 535                 540                 


Ser Val Asp His Glu Val Ser Thr Phe Val Phe Ile 
545                 550                 555     


<210>  4640
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  4640

Met Ala Ala Ala Asp Ala Glu Arg His Leu Trp Leu Pro Met Lys Ala 
1               5                   10                  15      


Gln Gln Arg Asn Arg Gln Glu Arg Pro Thr Trp Leu Arg Thr Val Arg 
            20                  25                  30          


Pro Met Gly Leu Val Lys Thr Ala Met Pro Ala Val Met Gln Met Leu 
        35                  40                  45              


Gln Ser Thr Leu Arg Thr Ala Gln Gly Ser Thr Pro Arg Met Ala Pro 
    50                  55                  60                  


Thr His 
65      


<210>  4641
<211>  106
<212>  PRT
<213>  Homo Sapiens

<400>  4641

Met Ala Ala Asp Glu Gly Ser Ala Glu Lys Gln Ala Gly Glu Ala His 
1               5                   10                  15      


Met Ala Ala Asp Gly Glu Thr Asn Gly Ser Cys Glu Asn Ser Asp Ala 
            20                  25                  30          


Ser Ser His Ala Asn Ala Ala Lys His Thr Gln Asp Ser Ala Arg Val 
        35                  40                  45              


Asn Pro Gln Asp Gly Thr Asn Thr Leu Thr Arg Ile Ala Glu Asn Gly 
    50                  55                  60                  


Val Ser Glu Arg Asp Ser Glu Ala Ala Lys Gln Asn His Val Thr Ala 
65                  70                  75                  80  


Asp Asp Phe Val Gln Thr Ser Val Ile Gly Ser Asn Gly Tyr Ile Leu 
                85                  90                  95      


Asn Lys Pro Ala Leu Gln Ala Gln Pro Leu 
            100                 105     


<210>  4642
<211>  134
<212>  PRT
<213>  Homo Sapiens

<400>  4642

Met Ala Ala Asp Glu Gly Ser Ala Glu Lys Gln Ala Gly Glu Ala His 
1               5                   10                  15      


Met Ala Ala Asp Gly Glu Thr Asn Gly Ser Cys Glu Asn Ser Asp Ala 
            20                  25                  30          


Ser Ser His Ala Asn Ala Ala Lys His Thr Gln Asp Ser Ala Arg Val 
        35                  40                  45              


Asn Pro Gln Asp Gly Thr Asn Thr Leu Thr Arg Ile Ala Glu Asn Gly 
    50                  55                  60                  


Val Ser Glu Arg Asp Ser Glu Ala Ala Lys Gln Asn His Val Thr Ala 
65                  70                  75                  80  


Asp Asp Phe Val Gln Thr Ser Val Ile Gly Ser Asn Gly Tyr Ile Leu 
                85                  90                  95      


Asn Lys Pro Ala Leu Gln Ala Gln Pro Leu Arg Thr Thr Ser Thr Leu 
            100                 105                 110         


Ala Ser Ser Leu Pro Gly His Ala Ala Lys Thr Leu Pro Gly Gly Ala 
        115                 120                 125             


Gly Lys Gly Arg Thr Pro 
    130                 


<210>  4643
<211>  137
<212>  PRT
<213>  Homo Sapiens

<400>  4643

Met Ala Ala Asp Glu Gly Ser Ala Glu Lys Gln Ala Gly Glu Ala His 
1               5                   10                  15      


Met Ala Ala Asp Gly Glu Thr Asn Gly Ser Cys Glu Asn Ser Asp Ala 
            20                  25                  30          


Ser Ser His Ala Asn Ala Ala Lys His Thr Gln Asp Ser Ala Arg Val 
        35                  40                  45              


Asn Pro Gln Asp Gly Thr Asn Thr Leu Thr Arg Ile Ala Glu Asn Gly 
    50                  55                  60                  


Val Ser Glu Arg Asp Ser Glu Ala Ala Lys Gln Asn His Val Thr Ala 
65                  70                  75                  80  


Asp Asp Phe Val Gln Thr Ser Val Ile Gly Ser Asn Gly Tyr Ile Leu 
                85                  90                  95      


Asn Lys Pro Ala Leu Gln Ala Gln Pro Leu Arg Thr Thr Ser Thr Leu 
            100                 105                 110         


Ala Ser Ser Leu Pro Gly His Ala Ala Lys Thr Leu Pro Gly Gly Ala 
        115                 120                 125             


Gly Lys Gly Arg Thr Pro Ser Ala Phe 
    130                 135         


<210>  4644
<211>  139
<212>  PRT
<213>  Homo Sapiens

<400>  4644

Met Ala Ala Asp Glu Gly Ser Ala Glu Lys Gln Ala Gly Glu Ala His 
1               5                   10                  15      


Met Ala Ala Asp Gly Glu Thr Asn Gly Ser Cys Glu Asn Ser Asp Ala 
            20                  25                  30          


Ser Ser His Ala Asn Ala Ala Lys His Thr Gln Asp Ser Ala Arg Val 
        35                  40                  45              


Asn Pro Gln Asp Gly Thr Asn Thr Leu Thr Arg Ile Ala Glu Asn Gly 
    50                  55                  60                  


Val Ser Glu Arg Asp Ser Glu Ala Ala Lys Gln Asn His Val Thr Ala 
65                  70                  75                  80  


Asp Asp Phe Val Gln Thr Ser Val Ile Gly Ser Asn Gly Tyr Ile Leu 
                85                  90                  95      


Asn Lys Pro Ala Leu Gln Ala Gln Pro Leu Arg Thr Thr Ser Thr Leu 
            100                 105                 110         


Ala Ser Ser Leu Pro Gly His Ala Ala Lys Thr Leu Pro Gly Gly Ala 
        115                 120                 125             


Gly Lys Gly Arg Thr Pro Ser Ala Phe Pro Gln 
    130                 135                 


<210>  4645
<211>  982
<212>  PRT
<213>  Homo Sapiens

<400>  4645

Met Ala Ala Asp Glu Gly Ser Ala Glu Lys Gln Ala Gly Glu Ala His 
1               5                   10                  15      


Met Ala Ala Asp Gly Glu Thr Asn Gly Ser Cys Glu Asn Ser Asp Ala 
            20                  25                  30          


Ser Ser His Ala Asn Ala Ala Lys His Thr Gln Asp Ser Ala Arg Val 
        35                  40                  45              


Asn Pro Gln Asp Gly Thr Asn Thr Leu Thr Arg Ile Ala Glu Asn Gly 
    50                  55                  60                  


Val Ser Glu Arg Asp Ser Glu Ala Ala Lys Gln Asn His Val Thr Ala 
65                  70                  75                  80  


Asp Asp Phe Val Gln Thr Ser Val Ile Gly Ser Asn Gly Tyr Ile Leu 
                85                  90                  95      


Asn Lys Pro Ala Leu Gln Ala Gln Pro Leu Arg Thr Thr Ser Thr Leu 
            100                 105                 110         


Ala Ser Ser Leu Pro Gly His Ala Ala Lys Thr Leu Pro Gly Gly Ala 
        115                 120                 125             


Gly Lys Gly Arg Thr Pro Ser Ala Phe Pro Gln Thr Pro Ala Ala Pro 
    130                 135                 140                 


Pro Ala Thr Leu Gly Glu Gly Ser Ala Asp Thr Glu Asp Arg Lys Leu 
145                 150                 155                 160 


Pro Ala Pro Gly Ala Asp Val Lys Val His Arg Ala Arg Lys Thr Met 
                165                 170                 175     


Pro Lys Ser Val Val Gly Leu His Ala Ala Ser Lys Asp Pro Arg Glu 
            180                 185                 190         


Val Arg Glu Ala Arg Asp His Lys Glu Pro Lys Glu Glu Ile Asn Lys 
        195                 200                 205             


Asn Ile Ser Asp Phe Gly Arg Gln Gln Leu Leu Pro Pro Phe Pro Ser 
    210                 215                 220                 


Leu His Gln Ser Leu Pro Gln Asn Gln Cys Tyr Met Ala Thr Thr Lys 
225                 230                 235                 240 


Ser Gln Thr Ala Ala Ala Val Ser Arg Lys Lys Lys Arg Arg Met Gly 
                245                 250                 255     


Thr Tyr Ser Leu Val Pro Lys Lys Lys Thr Lys Val Leu Lys Gln Arg 
            260                 265                 270         


Thr Val Ile Glu Met Phe Lys Ser Ile Thr His Ser Thr Val Gly Ser 
        275                 280                 285             


Lys Gly Glu Lys Asp Leu Gly Ala Ser Ser Leu His Val Asn Gly Glu 
    290                 295                 300                 


Ser Leu Glu Met Asp Ser Asp Glu Asp Asp Ser Glu Glu Leu Glu Glu 
305                 310                 315                 320 


Asp Asp Gly His Gly Ala Glu Gln Ala Ala Ala Phe Pro Thr Glu Asp 
                325                 330                 335     


Ser Arg Thr Ser Lys Glu Ser Met Ser Glu Ala Asp Arg Ala Gln Lys 
            340                 345                 350         


Met Asp Gly Glu Ser Glu Glu Glu Gln Glu Ser Val Asp Thr Gly Glu 
        355                 360                 365             


Glu Glu Glu Gly Gly Asp Glu Ser Asp Leu Ser Ser Glu Ser Ser Ile 
    370                 375                 380                 


Lys Lys Lys Phe Leu Lys Arg Lys Gly Lys Thr Asp Ser Pro Trp Ile 
385                 390                 395                 400 


Lys Pro Ala Arg Lys Arg Arg Arg Arg Ser Arg Lys Lys Pro Ser Gly 
                405                 410                 415     


Ala Leu Gly Ser Glu Ser Tyr Lys Ser Ser Ala Gly Ser Ala Glu Gln 
            420                 425                 430         


Thr Ala Pro Gly Asp Ser Thr Gly Tyr Met Glu Val Ser Leu Asp Ser 
        435                 440                 445             


Leu Asp Leu Arg Val Lys Gly Ile Leu Ser Ser Gln Ala Glu Gly Leu 
    450                 455                 460                 


Ala Asn Gly Pro Asp Val Leu Glu Thr Asp Gly Leu Gln Glu Val Pro 
465                 470                 475                 480 


Leu Cys Ser Cys Arg Met Glu Thr Pro Lys Ser Arg Glu Ile Thr Thr 
                485                 490                 495     


Leu Ala Asn Asn Gln Cys Met Ala Thr Glu Ser Val Asp His Glu Leu 
            500                 505                 510         


Gly Arg Cys Thr Asn Ser Val Val Lys Tyr Glu Leu Met Arg Pro Ser 
        515                 520                 525             


Asn Lys Ala Pro Leu Leu Val Leu Cys Glu Asp His Arg Gly Arg Met 
    530                 535                 540                 


Val Lys His Gln Cys Cys Pro Gly Cys Gly Tyr Phe Cys Thr Ala Gly 
545                 550                 555                 560 


Asn Phe Met Glu Cys Gln Pro Glu Ser Ser Ile Ser His Arg Phe His 
                565                 570                 575     


Lys Asp Cys Ala Ser Arg Val Asn Asn Ala Ser Tyr Cys Pro His Cys 
            580                 585                 590         


Gly Glu Glu Ser Ser Lys Ala Lys Glu Val Thr Ile Ala Lys Ala Asp 
        595                 600                 605             


Thr Thr Ser Thr Val Thr Pro Val Pro Gly Gln Glu Lys Gly Ser Ala 
    610                 615                 620                 


Leu Glu Gly Arg Ala Asp Thr Thr Thr Gly Ser Ala Ala Gly Pro Pro 
625                 630                 635                 640 


Leu Ser Glu Asp Asp Lys Leu Gln Gly Ala Ala Ser His Val Pro Glu 
                645                 650                 655     


Gly Phe Asp Pro Thr Gly Pro Ala Gly Leu Gly Arg Pro Thr Pro Gly 
            660                 665                 670         


Leu Ser Gln Gly Pro Gly Lys Glu Thr Leu Glu Ser Ala Leu Ile Ala 
        675                 680                 685             


Leu Asp Ser Glu Lys Pro Lys Lys Leu Arg Phe His Pro Lys Gln Leu 
    690                 695                 700                 


Tyr Phe Ser Ala Arg Gln Gly Glu Leu Gln Lys Val Leu Leu Met Leu 
705                 710                 715                 720 


Val Asp Gly Ile Asp Pro Asn Phe Lys Met Glu His Gln Asn Lys Arg 
                725                 730                 735     


Ser Pro Leu His Ala Ala Ala Glu Ala Gly His Val Asp Ile Cys His 
            740                 745                 750         


Met Leu Val Gln Ala Gly Ala Asn Ile Asp Thr Cys Ser Glu Asp Gln 
        755                 760                 765             


Arg Thr Pro Leu Met Glu Ala Ala Glu Asn Asn His Leu Glu Ala Val 
    770                 775                 780                 


Lys Tyr Leu Ile Lys Ala Gly Ala Leu Val Asp Pro Lys Asp Ala Glu 
785                 790                 795                 800 


Gly Ser Thr Cys Leu His Leu Ala Ala Lys Lys Gly His Tyr Glu Val 
                805                 810                 815     


Val Gln Tyr Leu Leu Ser Asn Gly Gln Met Asp Val Asn Cys Gln Asp 
            820                 825                 830         


Asp Gly Gly Trp Thr Pro Met Ile Trp Ala Thr Glu Tyr Lys His Val 
        835                 840                 845             


Asp Leu Val Lys Leu Leu Leu Ser Lys Gly Ser Asp Ile Asn Ile Arg 
    850                 855                 860                 


Asp Asn Glu Glu Asn Ile Cys Leu His Trp Ala Ala Phe Ser Gly Cys 
865                 870                 875                 880 


Val Asp Ile Ala Glu Ile Leu Leu Ala Ala Lys Cys Asp Leu His Ala 
                885                 890                 895     


Val Asn Ile His Gly Asp Ser Pro Leu His Ile Ala Ala Arg Glu Asn 
            900                 905                 910         


Arg Tyr Asp Cys Val Val Leu Phe Leu Ser Arg Asp Ser Asp Val Thr 
        915                 920                 925             


Leu Lys Asn Lys Glu Gly Glu Thr Pro Leu Gln Cys Ala Ser Leu Asn 
    930                 935                 940                 


Ser Gln Val Trp Ser Ala Leu Gln Met Ser Lys Ala Leu Gln Asp Ser 
945                 950                 955                 960 


Ala Pro Asp Arg Pro Ser Pro Val Glu Arg Ile Val Ser Arg Asp Ile 
                965                 970                 975     


Ala Arg Gly Tyr Glu Arg 
            980         


<210>  4646
<211>  1267
<212>  PRT
<213>  Homo Sapiens

<400>  4646

Met Ala Ala Asp Glu Gly Ser Ala Glu Lys Gln Ala Gly Glu Ala His 
1               5                   10                  15      


Met Ala Ala Asp Gly Glu Thr Asn Gly Ser Cys Glu Asn Ser Asp Ala 
            20                  25                  30          


Ser Ser His Ala Asn Ala Ala Lys His Thr Gln Asp Ser Ala Arg Val 
        35                  40                  45              


Asn Pro Gln Asp Gly Thr Asn Thr Leu Thr Arg Ile Ala Glu Asn Gly 
    50                  55                  60                  


Val Ser Glu Arg Asp Ser Glu Ala Ala Lys Gln Asn His Val Thr Ala 
65                  70                  75                  80  


Asp Asp Phe Val Gln Thr Ser Val Ile Gly Ser Asn Gly Tyr Ile Leu 
                85                  90                  95      


Asn Lys Pro Ala Leu Gln Ala Gln Pro Leu Arg Thr Thr Ser Thr Leu 
            100                 105                 110         


Ala Ser Ser Leu Pro Gly His Ala Ala Lys Thr Leu Pro Gly Gly Ala 
        115                 120                 125             


Gly Lys Gly Arg Thr Pro Ser Ala Phe Pro Gln Thr Pro Ala Ala Pro 
    130                 135                 140                 


Pro Ala Thr Leu Gly Glu Gly Ser Ala Asp Thr Glu Asp Arg Lys Leu 
145                 150                 155                 160 


Pro Ala Pro Gly Ala Asp Val Lys Val His Arg Ala Arg Lys Thr Met 
                165                 170                 175     


Pro Lys Ser Val Val Gly Leu His Ala Ala Ser Lys Asp Pro Arg Glu 
            180                 185                 190         


Val Arg Glu Ala Arg Asp His Lys Glu Pro Lys Glu Glu Ile Asn Lys 
        195                 200                 205             


Asn Ile Ser Asp Phe Gly Arg Gln Gln Leu Leu Pro Pro Phe Pro Ser 
    210                 215                 220                 


Leu His Gln Ser Leu Pro Gln Asn Gln Cys Tyr Met Ala Thr Thr Lys 
225                 230                 235                 240 


Ser Gln Thr Ala Cys Leu Pro Phe Val Leu Ala Ala Ala Val Ser Arg 
                245                 250                 255     


Lys Lys Lys Arg Arg Met Gly Thr Tyr Ser Leu Val Pro Lys Lys Lys 
            260                 265                 270         


Thr Lys Val Leu Lys Gln Arg Thr Val Ile Glu Met Phe Lys Ser Ile 
        275                 280                 285             


Thr His Ser Thr Val Gly Ser Lys Gly Glu Lys Asp Leu Gly Ala Ser 
    290                 295                 300                 


Ser Leu His Val Asn Gly Glu Ser Leu Glu Met Asp Ser Asp Glu Asp 
305                 310                 315                 320 


Asp Ser Glu Glu Leu Glu Glu Asp Asp Gly His Gly Ala Glu Gln Ala 
                325                 330                 335     


Ala Ala Phe Pro Thr Glu Asp Ser Arg Thr Ser Lys Glu Ser Met Ser 
            340                 345                 350         


Glu Ala Asp Arg Ala Gln Lys Met Asp Gly Glu Ser Glu Glu Glu Gln 
        355                 360                 365             


Glu Ser Val Asp Thr Gly Glu Glu Glu Glu Gly Gly Asp Glu Ser Asp 
    370                 375                 380                 


Leu Ser Ser Glu Ser Ser Ile Lys Lys Lys Phe Leu Lys Arg Lys Gly 
385                 390                 395                 400 


Lys Thr Asp Ser Pro Trp Ile Lys Pro Ala Arg Lys Arg Arg Arg Arg 
                405                 410                 415     


Ser Arg Lys Lys Pro Ser Gly Ala Leu Gly Ser Glu Ser Tyr Lys Ser 
            420                 425                 430         


Ser Ala Gly Ser Ala Glu Gln Thr Ala Pro Gly Asp Ser Thr Gly Tyr 
        435                 440                 445             


Met Glu Val Ser Leu Asp Ser Leu Asp Leu Arg Val Lys Gly Ile Leu 
    450                 455                 460                 


Ser Ser Gln Ala Glu Gly Leu Ala Asn Gly Pro Asp Val Leu Glu Thr 
465                 470                 475                 480 


Asp Gly Leu Gln Glu Val Pro Leu Cys Ser Cys Arg Met Glu Thr Pro 
                485                 490                 495     


Lys Ser Arg Glu Ile Thr Thr Leu Ala Asn Asn Gln Cys Met Ala Thr 
            500                 505                 510         


Glu Ser Val Asp His Glu Leu Gly Arg Cys Thr Asn Ser Val Val Lys 
        515                 520                 525             


Tyr Glu Leu Met Arg Pro Ser Asn Lys Ala Pro Leu Leu Val Leu Cys 
    530                 535                 540                 


Glu Asp His Arg Gly Arg Met Val Lys His Gln Cys Cys Pro Gly Cys 
545                 550                 555                 560 


Gly Tyr Phe Cys Thr Ala Gly Asn Phe Met Glu Cys Gln Pro Glu Ser 
                565                 570                 575     


Ser Ile Ser His Arg Phe His Lys Asp Cys Ala Ser Arg Val Asn Asn 
            580                 585                 590         


Ala Ser Tyr Cys Pro His Cys Gly Glu Glu Ser Ser Lys Ala Lys Glu 
        595                 600                 605             


Val Thr Ile Ala Lys Ala Asp Thr Thr Ser Thr Val Thr Pro Val Pro 
    610                 615                 620                 


Gly Gln Glu Lys Gly Ser Ala Leu Glu Gly Arg Ala Asp Thr Thr Thr 
625                 630                 635                 640 


Gly Ser Ala Ala Gly Pro Pro Leu Ser Glu Asp Asp Lys Leu Gln Gly 
                645                 650                 655     


Ala Ala Ser His Val Pro Glu Gly Phe Asp Pro Thr Gly Pro Ala Gly 
            660                 665                 670         


Leu Gly Arg Pro Thr Pro Gly Leu Ser Gln Gly Pro Gly Lys Glu Thr 
        675                 680                 685             


Leu Glu Ser Ala Leu Ile Ala Leu Asp Ser Glu Lys Pro Lys Lys Leu 
    690                 695                 700                 


Arg Phe His Pro Lys Gln Leu Tyr Phe Ser Ala Arg Gln Gly Glu Leu 
705                 710                 715                 720 


Gln Lys Val Leu Leu Met Leu Val Asp Gly Ile Asp Pro Asn Phe Lys 
                725                 730                 735     


Met Glu His Gln Asn Lys Arg Ser Pro Leu His Ala Ala Ala Glu Ala 
            740                 745                 750         


Gly His Val Asp Ile Cys His Met Leu Val Gln Ala Gly Ala Asn Ile 
        755                 760                 765             


Asp Thr Cys Ser Glu Asp Gln Arg Thr Pro Leu Met Glu Ala Ala Glu 
    770                 775                 780                 


Asn Asn His Leu Glu Ala Val Lys Tyr Leu Ile Lys Ala Gly Ala Leu 
785                 790                 795                 800 


Val Asp Pro Lys Asp Ala Glu Gly Ser Thr Cys Leu His Leu Ala Ala 
                805                 810                 815     


Lys Lys Gly His Tyr Glu Val Val Gln Tyr Leu Leu Ser Asn Gly Gln 
            820                 825                 830         


Met Asp Val Asn Cys Gln Asp Asp Gly Gly Trp Thr Pro Met Ile Trp 
        835                 840                 845             


Ala Thr Glu Tyr Lys His Val Asp Leu Val Lys Leu Leu Leu Ser Lys 
    850                 855                 860                 


Gly Ser Asp Ile Asn Ile Arg Asp Asn Glu Glu Asn Ile Cys Leu His 
865                 870                 875                 880 


Trp Ala Ala Phe Ser Gly Cys Val Asp Ile Ala Glu Ile Leu Leu Ala 
                885                 890                 895     


Ala Lys Cys Asp Leu His Ala Val Asn Ile His Gly Asp Ser Pro Leu 
            900                 905                 910         


His Ile Ala Ala Arg Glu Asn Arg Tyr Asp Cys Val Val Leu Phe Leu 
        915                 920                 925             


Ser Arg Asp Ser Asp Val Thr Leu Lys Asn Lys Glu Gly Glu Thr Pro 
    930                 935                 940                 


Leu Gln Cys Ala Ser Leu Asn Ser Gln Val Trp Ser Ala Leu Gln Met 
945                 950                 955                 960 


Ser Lys Ala Leu Gln Asp Ser Ala Pro Asp Arg Pro Ser Pro Val Glu 
                965                 970                 975     


Arg Ile Val Ser Arg Asp Ile Ala Arg Gly Tyr Glu Arg Ile Pro Ile 
            980                 985                 990         


Pro Cys Val Asn Ala Val Asp Ser  Glu Pro Cys Pro Ser  Asn Tyr Lys 
        995                 1000                 1005             


Tyr Val  Ser Gln Asn Cys Val  Thr Ser Pro Met Asn  Ile Asp Arg 
    1010                 1015                 1020             


Asn Ile  Thr His Leu Gln Tyr  Cys Val Cys Ile Asp  Asp Cys Ser 
    1025                 1030                 1035             


Ser Ser  Asn Cys Met Cys Gly  Gln Leu Ser Met Arg  Cys Trp Tyr 
    1040                 1045                 1050             


Asp Lys  Asp Gly Arg Leu Leu  Pro Glu Phe Asn Met  Ala Glu Pro 
    1055                 1060                 1065             


Pro Leu  Ile Phe Glu Cys Asn  His Ala Cys Ser Cys  Trp Arg Asn 
    1070                 1075                 1080             


Cys Arg  Asn Arg Val Val Gln  Asn Gly Leu Arg Ala  Arg Leu Gln 
    1085                 1090                 1095             


Leu Tyr  Arg Thr Arg Asp Met  Gly Trp Gly Val Arg  Ser Leu Gln 
    1100                 1105                 1110             


Asp Ile  Pro Pro Gly Thr Phe  Val Cys Glu Tyr Val  Gly Glu Leu 
    1115                 1120                 1125             


Ile Ser  Asp Ser Glu Ala Asp  Val Arg Glu Glu Asp  Ser Tyr Leu 
    1130                 1135                 1140             


Phe Asp  Leu Asp Asn Lys Asp  Gly Glu Val Tyr Cys  Ile Asp Ala 
    1145                 1150                 1155             


Arg Phe  Tyr Gly Asn Val Ser  Arg Phe Ile Asn His  His Cys Glu 
    1160                 1165                 1170             


Pro Asn  Leu Val Pro Val Arg  Val Phe Met Ala His  Gln Asp Leu 
    1175                 1180                 1185             


Arg Phe  Pro Arg Ile Ala Phe  Phe Ser Thr Arg Leu  Ile Glu Ala 
    1190                 1195                 1200             


Gly Glu  Gln Leu Gly Phe Asp  Tyr Gly Glu Arg Phe  Trp Asp Ile 
    1205                 1210                 1215             


Lys Gly  Lys Leu Phe Ser Cys  Arg Cys Gly Ser Pro  Lys Cys Arg 
    1220                 1225                 1230             


His Ser  Ser Ala Ala Leu Ala  Gln Arg Gln Ala Ser  Ala Ala Gln 
    1235                 1240                 1245             


Glu Ala  Gln Glu Asp Gly Leu  Pro Asp Thr Ser Ser  Ala Ala Ala 
    1250                 1255                 1260             


Ala Asp  Pro Leu 
    1265         


<210>  4647
<211>  117
<212>  PRT
<213>  Homo Sapiens

<400>  4647

Met Glu Ala Ala Glu Asn Asn His Leu Glu Ala Val Lys Tyr Leu Ile 
1               5                   10                  15      


Lys Ala Gly Ala Leu Val Asp Pro Lys Asp Ala Glu Gly Ser Thr Cys 
            20                  25                  30          


Leu His Leu Ala Ala Lys Lys Gly His Tyr Glu Val Val Gln Tyr Leu 
        35                  40                  45              


Leu Ser Asn Gly Gln Met Asp Val Asn Cys Gln Asp Asp Gly Gly Trp 
    50                  55                  60                  


Thr Pro Met Ile Trp Ala Thr Glu Tyr Lys His Val Asp Leu Val Lys 
65                  70                  75                  80  


Leu Leu Leu Ser Lys Gly Ser Asp Ile Asn Ile Arg Asp Asn Asp Asp 
                85                  90                  95      


Gly Thr Met Lys Arg Gly Ala Leu Ser Arg Gln Lys Glu Glu Lys Arg 
            100                 105                 110         


Glu Ala Glu Glu Pro 
        115         


<210>  4648
<211>  107
<212>  PRT
<213>  Homo Sapiens

<400>  4648

Met Glu Ala Ala Glu Asn Asn His Leu Glu Ala Val Lys Tyr Leu Ile 
1               5                   10                  15      


Lys Ala Gly Ala Leu Val Asp Pro Lys Asp Ala Glu Gly Ser Thr Cys 
            20                  25                  30          


Leu His Leu Ala Ala Lys Lys Gly His Tyr Glu Val Val Gln Tyr Leu 
        35                  40                  45              


Leu Ser Asn Gly Gln Met Asp Val Asn Cys Gln Asp Asp Gly Gly Trp 
    50                  55                  60                  


Thr Pro Met Ile Trp Ala Thr Glu Tyr Lys His Val Asp Leu Val Lys 
65                  70                  75                  80  


Leu Leu Leu Ser Lys Gly Ser Asp Ile Asn Ile Arg Asp Asn Arg Val 
                85                  90                  95      


Pro Glu Ala Arg Asn Gly Lys Ser Ser His Lys 
            100                 105         


<210>  4649
<211>  394
<212>  PRT
<213>  Homo Sapiens

<400>  4649

Met Gly Phe Ala Ala Ala Ala Val Ser Arg Lys Lys Lys Arg Arg Met 
1               5                   10                  15      


Gly Thr Tyr Ser Leu Val Pro Lys Lys Lys Thr Lys Val Leu Lys Gln 
            20                  25                  30          


Arg Thr Val Ile Glu Met Phe Lys Ser Ile Thr His Ser Thr Val Gly 
        35                  40                  45              


Ser Lys Gly Glu Lys Asp Leu Gly Ala Ser Ser Leu His Val Asn Gly 
    50                  55                  60                  


Glu Ser Leu Glu Met Asp Ser Asp Glu Asp Asp Ser Glu Glu Leu Glu 
65                  70                  75                  80  


Glu Asp Asp Gly His Gly Ala Glu Gln Ala Ala Ala Phe Pro Thr Glu 
                85                  90                  95      


Asp Ser Arg Thr Ser Lys Glu Ser Met Ser Glu Ala Asp Arg Ala Gln 
            100                 105                 110         


Lys Met Asp Gly Glu Ser Glu Glu Glu Gln Glu Ser Val Asp Thr Gly 
        115                 120                 125             


Glu Glu Glu Glu Gly Gly Asp Glu Ser Asp Leu Ser Ser Glu Ser Ser 
    130                 135                 140                 


Ile Lys Lys Lys Phe Leu Lys Arg Lys Gly Lys Thr Asp Ser Pro Trp 
145                 150                 155                 160 


Ile Lys Pro Ala Arg Lys Arg Arg Arg Arg Ser Arg Lys Lys Pro Ser 
                165                 170                 175     


Gly Ala Leu Gly Ser Glu Ser Tyr Lys Ser Ser Ala Gly Ser Ala Glu 
            180                 185                 190         


Gln Thr Ala Pro Gly Asp Ser Thr Gly Tyr Met Glu Val Ser Leu Asp 
        195                 200                 205             


Ser Leu Asp Leu Arg Val Lys Gly Ile Leu Ser Ser Gln Ala Glu Gly 
    210                 215                 220                 


Leu Ala Asn Gly Pro Asp Val Leu Glu Thr Asp Gly Leu Gln Glu Val 
225                 230                 235                 240 


Pro Leu Cys Ser Cys Arg Met Glu Thr Pro Lys Ser Arg Glu Ile Thr 
                245                 250                 255     


Thr Leu Ala Asn Asn Gln Cys Met Ala Thr Glu Ser Val Asp His Glu 
            260                 265                 270         


Leu Gly Arg Cys Thr Asn Ser Val Val Lys Tyr Glu Leu Met Arg Pro 
        275                 280                 285             


Ser Asn Lys Ala Pro Leu Leu Val Leu Cys Glu Asp His Arg Gly Arg 
    290                 295                 300                 


Met Val Lys His Gln Cys Cys Pro Gly Cys Gly Tyr Phe Cys Thr Ala 
305                 310                 315                 320 


Gly Asn Phe Met Glu Cys Gln Pro Glu Ser Ser Ile Ser His Arg Phe 
                325                 330                 335     


His Lys Asp Cys Ala Ser Arg Val Asn Asn Ala Ser Tyr Cys Pro His 
            340                 345                 350         


Cys Gly Glu Glu Ser Ser Lys Ala Lys Glu Val Thr Ile Ala Lys Ala 
        355                 360                 365             


Asp Thr Thr Ser Thr Val Thr Pro Val Pro Gly Gln Glu Lys Gly Ser 
    370                 375                 380                 


Ala Leu Glu Gly Arg Ala Asp Thr Thr Thr 
385                 390                 


<210>  4650
<211>  126
<212>  PRT
<213>  Homo Sapiens

<400>  4650

Met Gly Thr Tyr Ser Leu Val Pro Lys Lys Lys Thr Lys Val Leu Lys 
1               5                   10                  15      


Gln Arg Thr Val Ile Glu Met Phe Lys Ser Ile Thr His Ser Thr Val 
            20                  25                  30          


Gly Ser Lys Gly Glu Lys Asp Leu Gly Ala Ser Ser Leu His Val Asn 
        35                  40                  45              


Gly Glu Ser Leu Glu Met Asp Ser Asp Glu Asp Asp Ser Glu Glu Leu 
    50                  55                  60                  


Glu Glu Asp Asp Gly His Gly Ala Glu Gln Ala Ala Ala Phe Pro Thr 
65                  70                  75                  80  


Glu Asp Ser Arg Thr Ser Lys Glu Ser Met Ser Glu Ala Asp Arg Ala 
                85                  90                  95      


Gln Lys Lys His Glu Glu Glu Asn Thr Ala Ser Ser Pro His Cys Pro 
            100                 105                 110         


Gly Gly Ser Gly Thr Leu Lys Gln Ser Leu Gln Glu Leu Pro 
        115                 120                 125     


<210>  4651
<211>  126
<212>  PRT
<213>  Homo Sapiens

<400>  4651

Met Gly Thr Tyr Ser Leu Val Pro Lys Lys Lys Thr Lys Val Leu Lys 
1               5                   10                  15      


Gln Arg Thr Val Ile Glu Met Phe Lys Ser Ile Thr His Ser Thr Val 
            20                  25                  30          


Gly Ser Lys Gly Glu Lys Asp Leu Gly Ala Ser Ser Leu His Val Asn 
        35                  40                  45              


Gly Glu Ser Leu Glu Met Asp Ser Asp Glu Asp Asp Ser Glu Glu Leu 
    50                  55                  60                  


Glu Glu Asp Asp Gly His Gly Ala Glu Gln Ala Ala Ala Phe Pro Thr 
65                  70                  75                  80  


Glu Asp Ser Arg Thr Ser Lys Glu Ser Met Ser Glu Ala Asp Arg Ala 
                85                  90                  95      


Gln Lys Lys His Glu Glu Glu Asn Thr Ala Ser Ser Pro His Cys Pro 
            100                 105                 110         


Gly Gly Ser Gly Thr Leu Lys Gln Ser Leu Gln Glu Leu Pro 
        115                 120                 125     


<210>  4652
<211>  268
<212>  PRT
<213>  Homo Sapiens

<400>  4652

Met Leu Tyr Phe Ser Arg Ser His Phe Pro Arg Pro Cys Gly Gly Gln 
1               5                   10                  15      


Val Ser Ala Gly Ser Gly Leu Thr Leu Leu Leu Leu Leu Leu Pro Ala 
            20                  25                  30          


Leu Trp Arg Gly Trp Leu Glu Gly Asp Gly Gln Gln Ala Val Pro Ala 
        35                  40                  45              


Arg Gly Glu Pro Gln Gln Asp Cys Cys Val Lys Thr Glu Leu Leu Gly 
    50                  55                  60                  


Glu Glu Thr Pro Met Ala Ala Asp Glu Gly Ser Ala Glu Lys Gln Ala 
65                  70                  75                  80  


Gly Glu Ala His Met Ala Ala Asp Gly Glu Thr Asn Gly Ser Cys Glu 
                85                  90                  95      


Asn Ser Asp Ala Ser Ser His Ala Asn Ala Ala Lys His Thr Gln Asp 
            100                 105                 110         


Ser Ala Arg Val Asn Pro Gln Asp Gly Thr Asn Thr Leu Thr Arg Ile 
        115                 120                 125             


Ala Glu Asn Gly Val Ser Glu Arg Asp Ser Glu Ala Ala Lys Gln Asn 
    130                 135                 140                 


His Val Thr Ala Asp Asp Phe Val Gln Thr Ser Val Ile Gly Ser Asn 
145                 150                 155                 160 


Gly Tyr Ile Leu Asn Lys Pro Ala Leu Gln Ala Gln Pro Leu Arg Thr 
                165                 170                 175     


Thr Ser Thr Leu Ala Ser Ser Leu Pro Gly His Ala Ala Lys Thr Leu 
            180                 185                 190         


Pro Gly Gly Ala Gly Lys Gly Arg Thr Pro Ser Ala Phe Pro Gln Thr 
        195                 200                 205             


Pro Ala Ala Pro Pro Ala Thr Leu Gly Glu Gly Ser Ala Asp Thr Glu 
    210                 215                 220                 


Asp Arg Lys Leu Pro Ala Pro Gly Ala Asp Val Lys Val His Arg Ala 
225                 230                 235                 240 


Arg Lys Thr Met Pro Lys Ser Val Val Gly Leu His Ala Ala Ser Lys 
                245                 250                 255     


Asp Pro Arg Glu Val Arg Glu Ala Arg Asp His Lys 
            260                 265             


<210>  4653
<211>  803
<212>  PRT
<213>  Homo Sapiens

<400>  4653

Met Ser Glu Ala Asp Arg Ala Gln Lys Met Asp Gly Glu Ser Glu Glu 
1               5                   10                  15      


Glu Gln Glu Ser Val Asp Thr Gly Glu Glu Glu Glu Gly Gly Asp Glu 
            20                  25                  30          


Ser Asp Leu Ser Ser Glu Ser Ser Ile Lys Lys Lys Phe Leu Lys Arg 
        35                  40                  45              


Lys Gly Lys Thr Asp Ser Pro Trp Ile Lys Pro Ala Arg Lys Arg Arg 
    50                  55                  60                  


Arg Arg Ser Arg Lys Lys Pro Ser Gly Ala Leu Gly Ser Glu Ser Tyr 
65                  70                  75                  80  


Lys Ser Ser Ala Gly Ser Ala Glu Gln Thr Ala Pro Gly Asp Ser Thr 
                85                  90                  95      


Gly Tyr Met Glu Val Ser Leu Asp Ser Leu Asp Leu Arg Val Lys Gly 
            100                 105                 110         


Ile Leu Ser Ser Gln Ala Glu Gly Leu Ala Asn Gly Pro Asp Val Leu 
        115                 120                 125             


Glu Thr Asp Gly Leu Gln Glu Val Pro Leu Cys Ser Cys Arg Met Glu 
    130                 135                 140                 


Thr Pro Lys Ser Arg Glu Ile Thr Thr Leu Ala Asn Asn Gln Cys Met 
145                 150                 155                 160 


Ala Thr Glu Ser Val Asp His Glu Leu Gly Arg Cys Thr Asn Ser Val 
                165                 170                 175     


Val Lys Tyr Glu Leu Met Arg Pro Ser Asn Lys Ala Pro Leu Leu Val 
            180                 185                 190         


Leu Cys Glu Asp His Arg Gly Arg Met Val Lys His Gln Cys Cys Pro 
        195                 200                 205             


Gly Cys Gly Tyr Phe Cys Thr Ala Gly Asn Phe Met Glu Cys Gln Pro 
    210                 215                 220                 


Glu Ser Ser Ile Ser His Arg Phe His Lys Asp Cys Ala Ser Arg Val 
225                 230                 235                 240 


Asn Asn Ala Ser Tyr Cys Pro His Cys Gly Glu Glu Ser Ser Lys Ala 
                245                 250                 255     


Lys Glu Val Thr Ile Ala Lys Ala Asp Thr Thr Ser Thr Val Thr Pro 
            260                 265                 270         


Val Pro Gly Gln Glu Lys Gly Ser Ala Leu Glu Gly Arg Ala Asp Thr 
        275                 280                 285             


Thr Thr Gly Ser Ala Ala Gly Pro Pro Leu Ser Glu Asp Asp Lys Leu 
    290                 295                 300                 


Gln Gly Ala Ala Ser His Val Pro Glu Gly Phe Asp Pro Thr Gly Pro 
305                 310                 315                 320 


Ala Gly Leu Gly Arg Pro Thr Pro Gly Leu Ser Gln Gly Pro Gly Lys 
                325                 330                 335     


Glu Thr Leu Glu Ser Ala Leu Ile Ala Leu Asp Ser Glu Lys Pro Lys 
            340                 345                 350         


Lys Leu Arg Phe His Pro Lys Gln Leu Tyr Phe Ser Ala Arg Gln Gly 
        355                 360                 365             


Glu Leu Gln Lys Val Leu Leu Met Leu Val Asp Gly Ile Asp Pro Asn 
    370                 375                 380                 


Phe Lys Met Glu His Gln Asn Lys Arg Ser Pro Leu His Ala Ala Ala 
385                 390                 395                 400 


Glu Ala Gly His Val Asp Ile Cys His Met Leu Val Gln Ala Gly Ala 
                405                 410                 415     


Asn Ile Asp Thr Cys Ser Glu Asp Gln Arg Thr Pro Leu Met Glu Ala 
            420                 425                 430         


Ala Glu Asn Asn His Leu Glu Ala Val Lys Tyr Leu Ile Lys Ala Gly 
        435                 440                 445             


Ala Leu Val Asp Pro Lys Asp Ala Glu Gly Ser Thr Cys Leu His Leu 
    450                 455                 460                 


Ala Ala Lys Lys Gly His Tyr Glu Val Val Gln Tyr Leu Leu Ser Asn 
465                 470                 475                 480 


Gly Gln Met Asp Val Asn Cys Gln Asp Asp Gly Gly Trp Thr Pro Met 
                485                 490                 495     


Ile Trp Ala Thr Glu Tyr Lys His Val Asp Leu Val Lys Leu Leu Leu 
            500                 505                 510         


Ser Lys Gly Ser Asp Ile Asn Ile Arg Asp Asn Glu Glu Asn Ile Cys 
        515                 520                 525             


Leu His Trp Ala Ala Phe Ser Gly Cys Val Asp Ile Ala Glu Ile Leu 
    530                 535                 540                 


Leu Ala Ala Lys Cys Asp Leu His Ala Val Asn Ile His Gly Asp Ser 
545                 550                 555                 560 


Pro Leu His Ile Ala Ala Arg Glu Asn Arg Tyr Asp Cys Val Val Leu 
                565                 570                 575     


Phe Leu Ser Arg Asp Ser Asp Val Thr Leu Lys Asn Lys Glu Gly Glu 
            580                 585                 590         


Thr Pro Leu Gln Cys Ala Ser Leu Asn Ser Gln Val Trp Ser Ala Leu 
        595                 600                 605             


Gln Met Ser Lys Ala Leu Gln Asp Ser Ala Pro Asp Arg Pro Ser Pro 
    610                 615                 620                 


Val Glu Arg Ile Val Ser Arg Asp Ile Ala Arg Gly Tyr Glu Arg Ile 
625                 630                 635                 640 


Pro Ile Pro Cys Val Asn Ala Val Asp Ser Glu Pro Cys Pro Ser Asn 
                645                 650                 655     


Tyr Lys Tyr Val Ser Gln Asn Cys Val Thr Ser Pro Met Asn Ile Asp 
            660                 665                 670         


Arg Asn Ile Thr His Leu Gln Tyr Cys Val Cys Ile Asp Asp Cys Ser 
        675                 680                 685             


Ser Ser Asn Cys Met Cys Gly Gln Leu Ser Met Arg Cys Trp Tyr Asp 
    690                 695                 700                 


Lys Asp Gly Arg Leu Leu Pro Glu Phe Asn Met Ala Glu Pro Pro Leu 
705                 710                 715                 720 


Ile Phe Glu Cys Asn His Ala Cys Ser Cys Trp Arg Asn Cys Arg Asn 
                725                 730                 735     


Arg Val Val Gln Asn Gly Leu Arg Ala Arg Leu Gln Leu Tyr Arg Thr 
            740                 745                 750         


Arg Asp Met Gly Trp Gly Val Arg Ser Leu Gln Asp Ile Pro Pro Gly 
        755                 760                 765             


Thr Phe Val Cys Glu Tyr Val Gly Glu Leu Ile Ser Asp Ser Glu Ala 
    770                 775                 780                 


Asp Val Arg Glu Glu Asp Ser Tyr Leu Phe Asp Leu Asp Asn Lys Ile 
785                 790                 795                 800 


Ser Ser Ala 
            


<210>  4654
<211>  153
<212>  PRT
<213>  Homo Sapiens

<400>  4654

Ser Pro Leu His Ala Ala Ala Glu Ala Gly His Val Asp Ile Cys His 
1               5                   10                  15      


Met Leu Val Gln Ala Gly Ala Asn Ile Asp Thr Cys Ser Glu Asp Gln 
            20                  25                  30          


Arg Thr Pro Leu Met Glu Ala Ala Glu Asn Asn His Leu Glu Ala Val 
        35                  40                  45              


Lys Tyr Leu Ile Lys Ala Gly Ala Leu Val Asp Pro Lys Asp Ala Glu 
    50                  55                  60                  


Gly Ser Thr Cys Leu His Leu Ala Ala Lys Lys Gly His Tyr Glu Val 
65                  70                  75                  80  


Val Gln Tyr Leu Leu Ser Asn Gly Gln Met Asp Val Asn Cys Gln Asp 
                85                  90                  95      


Asp Gly Gly Trp Thr Pro Met Ile Trp Ala Thr Glu Tyr Lys His Val 
            100                 105                 110         


Asp Leu Val Lys Leu Leu Leu Ser Lys Gly Ser Asp Ile Asn Ile Arg 
        115                 120                 125             


Asp Asn Asp Asp Gly Thr Met Lys Arg Gly Ala Leu Ser Arg Gln Lys 
    130                 135                 140                 


Glu Glu Lys Arg Glu Ala Glu Glu Pro 
145                 150             


<210>  4655
<211>  277
<212>  PRT
<213>  Homo Sapiens

<400>  4655

Val Pro Ala Arg Gly Glu Pro Gln Gln Asp Cys Cys Val Lys Thr Glu 
1               5                   10                  15      


Leu Leu Gly Glu Glu Thr Pro Met Ala Ala Asp Glu Gly Ser Ala Glu 
            20                  25                  30          


Lys Gln Ala Gly Glu Ala His Met Ala Ala Asp Gly Glu Thr Asn Gly 
        35                  40                  45              


Ser Cys Glu Asn Ser Asp Ala Ser Ser His Ala Asn Ala Ala Lys His 
    50                  55                  60                  


Thr Gln Asp Ser Ala Arg Val Asn Pro Gln Asp Gly Thr Asn Thr Leu 
65                  70                  75                  80  


Thr Arg Ile Ala Glu Asn Gly Val Ser Glu Arg Asp Ser Glu Ala Ala 
                85                  90                  95      


Lys Gln Asn His Val Thr Ala Asp Asp Phe Val Gln Thr Ser Val Ile 
            100                 105                 110         


Gly Ser Asn Gly Tyr Ile Leu Asn Lys Pro Ala Leu Gln Ala Gln Pro 
        115                 120                 125             


Leu Arg Thr Thr Ser Thr Leu Ala Ser Ser Leu Pro Gly His Ala Ala 
    130                 135                 140                 


Lys Thr Leu Pro Gly Gly Ala Gly Lys Gly Arg Thr Pro Ser Ala Phe 
145                 150                 155                 160 


Pro Gln Thr Pro Ala Ala Pro Pro Ala Thr Leu Gly Glu Gly Ser Ala 
                165                 170                 175     


Asp Thr Glu Asp Arg Lys Leu Pro Ala Pro Gly Ala Asp Val Lys Val 
            180                 185                 190         


His Arg Ala Arg Lys Thr Met Pro Lys Ser Val Val Gly Leu His Ala 
        195                 200                 205             


Ala Ser Lys Asp Pro Arg Glu Val Arg Glu Ala Arg Asp His Lys Glu 
    210                 215                 220                 


Pro Lys Glu Glu Ile Asn Lys Asn Ile Ser Asp Phe Gly Arg Gln Gln 
225                 230                 235                 240 


Leu Leu Pro Pro Phe Pro Ser Leu His Gln Ser Leu Pro Gln Asn Gln 
                245                 250                 255     


Cys Tyr Met Ala Thr Thr Lys Ser Gln Thr Gly Lys Glu Asp Pro Ala 
            260                 265                 270         


Thr Val Ser Ala Leu 
        275         


<210>  4656
<211>  168
<212>  PRT
<213>  Homo Sapiens

<400>  4656

Trp Ile Lys Pro Ala Arg Lys Arg Arg Arg Arg Ser Arg Lys Lys Pro 
1               5                   10                  15      


Ser Gly Ala Leu Gly Ser Glu Ser Tyr Lys Ser Ser Ala Gly Ser Ala 
            20                  25                  30          


Glu Gln Thr Ala Pro Gly Asp Ser Thr Gly Tyr Met Glu Val Ser Leu 
        35                  40                  45              


Asp Ser Leu Asp Leu Arg Val Lys Gly Ile Leu Ser Ser Gln Ala Glu 
    50                  55                  60                  


Gly Leu Ala Asn Gly Pro Asp Val Leu Glu Thr Asp Gly Leu Gln Glu 
65                  70                  75                  80  


Val Pro Leu Cys Ser Cys Arg Met Glu Thr Pro Lys Ser Arg Glu Ile 
                85                  90                  95      


Thr Thr Leu Ala Asn Asn Gln Cys Met Ala Thr Glu Ser Val Asp His 
            100                 105                 110         


Glu Gly Asn Phe Met Glu Cys Gln Pro Glu Ser Ser Ile Ser His Arg 
        115                 120                 125             


Phe His Lys Asp Cys Ala Ser Arg Val Asn Asn Ala Ser Tyr Cys Pro 
    130                 135                 140                 


His Cys Gly Glu Glu Ser Ser Lys Ala Lys Glu Val Thr Ile Ala Lys 
145                 150                 155                 160 


Ala Asp Thr Thr Ser Thr Val Thr 
                165             


<210>  4657
<211>  543
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4657

Xaa Cys Val Lys Thr Glu Leu Leu Gly Glu Glu Thr Pro Met Ala Ala 
1               5                   10                  15      


Asp Glu Gly Ser Ala Glu Lys Gln Ala Gly Glu Ala His Met Ala Ala 
            20                  25                  30          


Asp Gly Glu Thr Asn Gly Ser Cys Glu Asn Ser Asp Ala Ser Ser His 
        35                  40                  45              


Ala Asn Ala Ala Lys His Thr Gln Asp Ser Ala Arg Val Asn Pro Gln 
    50                  55                  60                  


Asp Gly Thr Asn Thr Leu Thr Arg Ile Ala Glu Asn Gly Val Ser Glu 
65                  70                  75                  80  


Arg Asp Ser Glu Ala Ala Lys Gln Asn His Val Thr Ala Asp Asp Phe 
                85                  90                  95      


Val Gln Thr Ser Val Ile Gly Ser Asn Gly Tyr Ile Leu Asn Lys Pro 
            100                 105                 110         


Ala Leu Gln Ala Gln Pro Leu Arg Thr Thr Ser Thr Leu Ala Ser Ser 
        115                 120                 125             


Leu Pro Gly His Ala Ala Lys Thr Leu Pro Gly Gly Ala Gly Lys Gly 
    130                 135                 140                 


Arg Thr Pro Ser Ala Phe Pro Gln Thr Pro Ala Ala Pro Pro Ala Thr 
145                 150                 155                 160 


Leu Gly Glu Gly Ser Ala Asp Thr Glu Asp Arg Lys Leu Pro Ala Pro 
                165                 170                 175     


Gly Ala Asp Val Lys Val His Arg Ala Arg Lys Thr Met Pro Lys Ser 
            180                 185                 190         


Val Val Gly Leu His Ala Ala Ser Lys Asp Pro Arg Glu Val Arg Glu 
        195                 200                 205             


Ala Arg Asp His Lys Glu Pro Lys Glu Glu Ile Asn Lys Asn Ile Ser 
    210                 215                 220                 


Asp Phe Gly Arg Gln Gln Leu Leu Pro Pro Phe Pro Ser Leu His Gln 
225                 230                 235                 240 


Ser Leu Pro Gln Asn Gln Cys Tyr Met Ala Thr Thr Lys Ser Gln Thr 
                245                 250                 255     


Ala Cys Leu Pro Phe Val Leu Ala Ala Ala Val Ser Arg Lys Lys Lys 
            260                 265                 270         


Arg Arg Met Gly Thr Tyr Ser Leu Val Pro Lys Lys Lys Thr Lys Val 
        275                 280                 285             


Leu Lys Gln Arg Thr Val Ile Glu Met Phe Lys Ser Ile Thr His Ser 
    290                 295                 300                 


Thr Val Gly Ser Lys Gly Glu Lys Asp Leu Gly Ala Ser Ser Leu His 
305                 310                 315                 320 


Val Asn Gly Glu Ser Leu Glu Met Asp Ser Asp Glu Asp Asp Ser Glu 
                325                 330                 335     


Glu Leu Glu Glu Asp Asp Gly His Gly Ala Glu Gln Ala Ala Ala Phe 
            340                 345                 350         


Pro Thr Glu Asp Ser Arg Thr Ser Lys Glu Ser Met Ser Glu Ala Asp 
        355                 360                 365             


Arg Ala Gln Lys Met Asp Gly Glu Ser Glu Glu Glu Gln Glu Ser Val 
    370                 375                 380                 


Asp Thr Gly Glu Glu Glu Glu Gly Gly Asp Glu Ser Asp Leu Ser Ser 
385                 390                 395                 400 


Glu Ser Ser Ile Lys Lys Lys Phe Leu Lys Arg Lys Gly Lys Thr Asp 
                405                 410                 415     


Ser Pro Trp Ile Lys Pro Ala Arg Lys Arg Arg Arg Arg Ser Arg Lys 
            420                 425                 430         


Lys Pro Ser Gly Ala Leu Gly Ser Glu Ser Tyr Lys Ser Ser Ala Gly 
        435                 440                 445             


Ser Ala Glu Gln Thr Ala Pro Gly Asp Ser Thr Gly Tyr Met Glu Val 
    450                 455                 460                 


Ser Leu Asp Ser Leu Asp Leu Arg Val Lys Gly Ile Leu Ser Ser Gln 
465                 470                 475                 480 


Ala Glu Gly Leu Ala Asn Gly Pro Asp Val Leu Glu Thr Asp Gly Leu 
                485                 490                 495     


Gln Glu Val Pro Leu Cys Ser Cys Arg Met Glu Thr Pro Lys Ser Arg 
            500                 505                 510         


Glu Ile Thr Thr Leu Ala Asn Asn Gln Cys Met Ala Thr Glu Ser Val 
        515                 520                 525             


Asp His Glu Val Leu Asn Arg Ile Gln Trp Ser Gln Ile Pro Val 
    530                 535                 540             


<210>  4658
<211>  433
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4658

Xaa Gly Glu Glu Thr Pro Met Ala Ala Asp Glu Gly Ser Ala Glu Lys 
1               5                   10                  15      


Gln Ala Gly Glu Ala His Met Ala Ala Asp Gly Glu Thr Asn Gly Ser 
            20                  25                  30          


Cys Glu Asn Ser Asp Ala Ser Ser His Ala Asn Ala Ala Lys His Thr 
        35                  40                  45              


Gln Asp Ser Ala Arg Val Asn Pro Gln Asp Gly Thr Asn Thr Leu Thr 
    50                  55                  60                  


Arg Ile Ala Glu Asn Gly Val Ser Glu Arg Asp Ser Glu Ala Ala Lys 
65                  70                  75                  80  


Gln Asn His Val Thr Ala Asp Asp Phe Val Gln Thr Ser Val Ile Gly 
                85                  90                  95      


Ser Asn Gly Tyr Ile Leu Asn Lys Pro Ala Leu Gln Ala Gln Pro Leu 
            100                 105                 110         


Arg Thr Thr Ser Thr Leu Ala Ser Ser Leu Pro Gly His Ala Ala Lys 
        115                 120                 125             


Thr Leu Pro Gly Gly Ala Gly Lys Gly Arg Thr Pro Ser Ala Phe Pro 
    130                 135                 140                 


Gln Thr Pro Ala Ala Pro Pro Ala Thr Leu Gly Glu Gly Ser Ala Asp 
145                 150                 155                 160 


Thr Glu Asp Arg Lys Leu Pro Ala Pro Gly Ala Asp Val Lys Val His 
                165                 170                 175     


Arg Ala Arg Lys Thr Met Pro Lys Ser Val Val Gly Leu His Ala Ala 
            180                 185                 190         


Ser Lys Asp Pro Arg Glu Val Arg Glu Ala Arg Asp His Lys Glu Pro 
        195                 200                 205             


Lys Glu Glu Ile Asn Lys Asn Ile Ser Asp Phe Gly Arg Gln Gln Leu 
    210                 215                 220                 


Leu Pro Pro Phe Pro Ser Leu His Gln Ser Leu Pro Gln Asn Gln Cys 
225                 230                 235                 240 


Tyr Met Ala Thr Thr Lys Ser Gln Thr Ala Ala Ala Val Ser Arg Lys 
                245                 250                 255     


Lys Lys Arg Arg Met Gly Thr Tyr Ser Leu Val Pro Lys Lys Lys Thr 
            260                 265                 270         


Lys Val Leu Lys Gln Arg Thr Val Ile Glu Met Phe Lys Ser Ile Thr 
        275                 280                 285             


His Ser Thr Val Gly Ser Lys Gly Glu Lys Asp Leu Gly Ala Ser Ser 
    290                 295                 300                 


Leu His Val Asn Gly Glu Ser Leu Glu Met Asp Ser Asp Glu Asp Asp 
305                 310                 315                 320 


Ser Glu Glu Leu Glu Glu Asp Asp Gly His Gly Ala Glu Gln Ala Ala 
                325                 330                 335     


Ala Phe Pro Thr Glu Asp Ser Arg Thr Ser Lys Glu Ser Met Ser Glu 
            340                 345                 350         


Ala Asp Arg Ala Gln Lys Met Asp Gly Glu Ser Glu Glu Glu Gln Glu 
        355                 360                 365             


Ser Val Asp Thr Gly Glu Glu Glu Glu Gly Gly Asp Glu Ser Asp Leu 
    370                 375                 380                 


Ser Ser Glu Ser Ser Ile Lys Lys Lys Phe Leu Lys Arg Lys Gly Lys 
385                 390                 395                 400 


Thr Asp Ser Pro Trp Ile Lys Pro Ala Arg Lys Arg Arg Arg Arg Ser 
                405                 410                 415     


Arg Lys Lys Pro Ser Gly Ala Leu Gly Ser Glu Ser Tyr Lys Ser Ser 
            420                 425                 430         


Ala 
    


<210>  4659
<211>  112
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4659

Xaa Pro Ala Leu Gln Ala Gln Pro Leu Arg Thr Thr Ser Thr Leu Ala 
1               5                   10                  15      


Ser Ser Leu Pro Gly His Ala Ala Lys Thr Leu Pro Gly Gly Ala Gly 
            20                  25                  30          


Lys Gly Arg Thr Pro Ser Ala Phe Pro Gln Thr Pro Ala Ala Pro Pro 
        35                  40                  45              


Ala Thr Leu Gly Glu Gly Ser Ala Asp Thr Glu Asp Arg Lys Leu Pro 
    50                  55                  60                  


Ala Pro Gly Ala Asp Val Lys Val His Arg Ala Arg Lys Thr Met Pro 
65                  70                  75                  80  


Lys Ser Val Val Gly Leu Val Ile Leu Cys Leu Leu Leu Leu Phe Pro 
                85                  90                  95      


Phe Ser His Leu Phe Cys Phe Asn Asn Gly Lys Trp Thr Leu Val His 
            100                 105                 110         


<210>  4660
<211>  230
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4660

Xaa Pro Phe Val Leu Ala Ala Ala Val Ser Arg Lys Lys Lys Arg Arg 
1               5                   10                  15      


Met Gly Thr Tyr Ser Leu Val Pro Lys Lys Lys Thr Lys Val Leu Lys 
            20                  25                  30          


Gln Arg Thr Val Ile Glu Met Phe Lys Ser Ile Thr His Ser Thr Val 
        35                  40                  45              


Gly Ser Lys Gly Glu Lys Asp Leu Gly Ala Ser Ser Leu His Val Asn 
    50                  55                  60                  


Gly Glu Ser Leu Glu Met Asp Ser Asp Glu Asp Asp Ser Glu Glu Leu 
65                  70                  75                  80  


Glu Glu Asp Asp Gly His Gly Ala Glu Gln Ala Ala Ala Phe Pro Thr 
                85                  90                  95      


Glu Asp Ser Arg Thr Ser Lys Glu Ser Met Ser Glu Ala Asp Arg Ala 
            100                 105                 110         


Gln Lys Ser Ser Glu Ser Ser Ile Lys Lys Lys Phe Leu Lys Arg Lys 
        115                 120                 125             


Gly Lys Thr Asp Ser Pro Trp Ile Lys Pro Ala Arg Lys Arg Arg Arg 
    130                 135                 140                 


Arg Ser Arg Lys Lys Pro Ser Gly Ala Leu Gly Ser Glu Ser Tyr Lys 
145                 150                 155                 160 


Ser Ser Ala Gly Ser Ala Glu Gln Thr Ala Pro Gly Asp Ser Thr Gly 
                165                 170                 175     


Tyr Met Glu Val Ser Leu Asp Ser Leu Asp Leu Arg Val Lys Gly Ile 
            180                 185                 190         


Leu Ser Ser Gln Ala Glu Gly Leu Ala Asn Gly Pro Asp Val Leu Glu 
        195                 200                 205             


Thr Asp Gly Leu Gln Glu Val Pro Leu Cys Ser Cys Arg Met Glu Thr 
    210                 215                 220                 


Pro Lys Ser Arg Glu Ile 
225                 230 


<210>  4661
<211>  108
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4661

Xaa Pro Leu Met Glu Ala Ala Glu Asn Asn His Leu Glu Ala Val Lys 
1               5                   10                  15      


Tyr Leu Ile Lys Ala Gly Ala Leu Val Asp Pro Lys Asp Ala Glu Gly 
            20                  25                  30          


Ser Thr Cys Leu His Leu Ala Ala Lys Lys Gly His Tyr Glu Val Val 
        35                  40                  45              


Gln Tyr Leu Leu Ser Asn Gly Gln Met Asp Val Asn Cys Gln Asp Asp 
    50                  55                  60                  


Gly Gly Trp Thr Pro Met Ile Trp Ala Thr Glu Tyr Lys His Val Asp 
65                  70                  75                  80  


Leu Val Lys Leu Leu Leu Ser Lys Gly Ser Asp Ile Asn Ile Arg Asp 
                85                  90                  95      


Asn Val Gly Cys Ile Tyr Ser Lys Tyr Thr Leu Gly 
            100                 105             


<210>  4662
<211>  1176
<212>  PRT
<213>  Homo Sapiens

<400>  4662

Met Ala Ala Ala Ala Gly Ala Ala Ala Ala Ala Ala Ala Glu Gly Glu 
1               5                   10                  15      


Ala Pro Ala Glu Met Gly Ala Leu Leu Leu Glu Lys Glu Thr Arg Gly 
            20                  25                  30          


Ala Thr Glu Arg Val His Gly Ser Leu Gly Asp Thr Pro Arg Ser Glu 
        35                  40                  45              


Glu Thr Leu Pro Lys Ala Thr Pro Asp Ser Leu Glu Pro Ala Gly Pro 
    50                  55                  60                  


Ser Ser Pro Ala Ser Val Thr Val Thr Val Gly Asp Glu Gly Ala Asp 
65                  70                  75                  80  


Thr Pro Val Gly Ala Thr Pro Leu Ile Gly Asp Glu Ser Glu Asn Leu 
                85                  90                  95      


Glu Gly Asp Gly Asp Leu Arg Gly Gly Arg Ile Leu Leu Gly His Ala 
            100                 105                 110         


Thr Lys Ser Phe Pro Ser Ser Pro Ser Lys Gly Gly Ser Cys Pro Ser 
        115                 120                 125             


Arg Ala Lys Met Ser Met Thr Gly Ala Gly Lys Ser Pro Pro Ser Val 
    130                 135                 140                 


Gln Ser Leu Ala Met Arg Leu Leu Ser Met Pro Gly Ala Gln Gly Ala 
145                 150                 155                 160 


Ala Ala Ala Gly Ser Glu Pro Pro Pro Ala Thr Thr Ser Pro Glu Gly 
                165                 170                 175     


Gln Pro Lys Val His Arg Ala Arg Lys Thr Met Ser Lys Pro Gly Asn 
            180                 185                 190         


Gly Gln Pro Pro Val Pro Glu Lys Arg Pro Pro Glu Ile Gln His Phe 
        195                 200                 205             


Arg Met Ser Asp Asp Val His Ser Leu Gly Lys Val Thr Ser Asp Leu 
    210                 215                 220                 


Ala Lys Arg Arg Lys Leu Asn Ser Gly Gly Gly Leu Ser Glu Glu Leu 
225                 230                 235                 240 


Gly Ser Ala Arg Arg Ser Gly Glu Val Thr Leu Thr Lys Gly Asp Pro 
                245                 250                 255     


Gly Ser Leu Glu Glu Trp Glu Thr Val Val Gly Asp Asp Phe Ser Leu 
            260                 265                 270         


Tyr Tyr Asp Ser Tyr Ser Val Asp Glu Arg Val Asp Ser Asp Ser Lys 
        275                 280                 285             


Ser Glu Val Glu Ala Leu Thr Glu Gln Leu Ser Glu Glu Glu Glu Glu 
    290                 295                 300                 


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
305                 310                 315                 320 


Glu Glu Glu Asp Glu Glu Ser Gly Asn Gln Ser Asp Arg Ser Gly Ser 
                325                 330                 335     


Ser Gly Arg Arg Lys Ala Lys Lys Lys Trp Arg Lys Asp Ser Pro Trp 
            340                 345                 350         


Val Lys Pro Ser Arg Lys Arg Arg Lys Arg Glu Pro Pro Arg Ala Lys 
        355                 360                 365             


Glu Pro Arg Gly Val Ser Asn Asp Thr Ser Ser Leu Glu Thr Glu Arg 
    370                 375                 380                 


Gly Phe Glu Glu Leu Pro Leu Cys Ser Cys Arg Met Glu Ala Pro Lys 
385                 390                 395                 400 


Ile Asp Arg Ile Ser Glu Arg Ala Gly His Lys Cys Met Ala Thr Glu 
                405                 410                 415     


Ser Val Asp Gly Glu Leu Ser Gly Cys Asn Ala Ala Ile Leu Lys Arg 
            420                 425                 430         


Glu Thr Met Arg Pro Ser Ser Arg Val Ala Leu Met Val Leu Cys Glu 
        435                 440                 445             


Thr His Arg Ala Arg Met Val Lys His His Cys Cys Pro Gly Cys Gly 
    450                 455                 460                 


Tyr Phe Cys Thr Ala Gly Thr Phe Leu Glu Cys His Pro Asp Phe Arg 
465                 470                 475                 480 


Val Ala His Arg Phe His Lys Ala Cys Val Ser Gln Leu Asn Gly Met 
                485                 490                 495     


Val Phe Cys Pro His Cys Gly Glu Asp Ala Ser Glu Ala Gln Glu Val 
            500                 505                 510         


Thr Ile Pro Arg Gly Asp Gly Val Thr Pro Pro Ala Gly Thr Ala Ala 
        515                 520                 525             


Pro Ala Pro Pro Pro Leu Ser Gln Asp Val Pro Gly Arg Ala Asp Thr 
    530                 535                 540                 


Ser Gln Pro Ser Ala Arg Met Arg Gly His Gly Glu Pro Arg Arg Pro 
545                 550                 555                 560 


Pro Cys Asp Pro Leu Ala Asp Thr Ile Asp Ser Ser Gly Pro Ser Leu 
                565                 570                 575     


Thr Leu Pro Asn Gly Gly Cys Leu Ser Ala Val Gly Leu Pro Leu Gly 
            580                 585                 590         


Pro Gly Arg Glu Ala Leu Glu Lys Ala Leu Val Ile Gln Glu Ser Glu 
        595                 600                 605             


Arg Arg Lys Lys Leu Arg Phe His Pro Arg Gln Leu Tyr Leu Ser Val 
    610                 615                 620                 


Lys Gln Gly Glu Leu Gln Lys Val Ile Leu Met Leu Leu Asp Asn Leu 
625                 630                 635                 640 


Asp Pro Asn Phe Gln Ser Asp Gln Gln Ser Lys Arg Thr Pro Leu His 
                645                 650                 655     


Ala Ala Ala Gln Lys Gly Ser Val Glu Ile Cys His Val Leu Leu Gln 
            660                 665                 670         


Ala Gly Ala Asn Ile Asn Ala Val Asp Lys Gln Gln Arg Thr Pro Leu 
        675                 680                 685             


Met Glu Ala Val Val Asn Asn His Leu Glu Val Ala Arg Tyr Met Val 
    690                 695                 700                 


Gln Arg Gly Gly Cys Val Tyr Ser Lys Glu Glu Asp Gly Ser Thr Cys 
705                 710                 715                 720 


Leu His His Ala Ala Lys Ile Gly Asn Leu Glu Met Val Ser Leu Leu 
                725                 730                 735     


Leu Ser Thr Gly Gln Val Asp Val Asn Ala Gln Asp Ser Gly Gly Trp 
            740                 745                 750         


Thr Pro Ile Ile Trp Ala Ala Glu His Lys His Ile Glu Val Ile Arg 
        755                 760                 765             


Met Leu Leu Thr Arg Gly Ala Asp Val Thr Leu Thr Asp Asn Glu Glu 
    770                 775                 780                 


Asn Ile Cys Leu His Trp Ala Ser Phe Thr Gly Ser Ala Ala Ile Ala 
785                 790                 795                 800 


Glu Val Leu Leu Asn Ala Arg Cys Asp Leu His Ala Val Asn Tyr His 
                805                 810                 815     


Gly Asp Thr Pro Leu His Ile Ala Ala Arg Glu Ser Tyr His Asp Cys 
            820                 825                 830         


Val Leu Leu Phe Leu Ser Arg Gly Ala Asn Pro Glu Leu Arg Asn Lys 
        835                 840                 845             


Glu Gly Asp Thr Ala Trp Asp Leu Thr Pro Glu Arg Ser Asp Val Trp 
    850                 855                 860                 


Phe Ala Leu Gln Leu Asn Arg Lys Leu Arg Leu Gly Val Gly Asn Arg 
865                 870                 875                 880 


Ala Ile Arg Thr Glu Lys Ile Ile Cys Arg Asp Val Ala Arg Gly Tyr 
                885                 890                 895     


Glu Asn Val Pro Ile Pro Cys Val Asn Gly Val Asp Gly Glu Pro Cys 
            900                 905                 910         


Pro Glu Asp Tyr Lys Tyr Ile Ser Glu Asn Cys Glu Thr Ser Thr Met 
        915                 920                 925             


Asn Ile Asp Arg Asn Ile Thr His Leu Gln His Cys Thr Cys Val Asp 
    930                 935                 940                 


Asp Cys Ser Ser Ser Asn Cys Leu Cys Gly Gln Leu Ser Ile Arg Cys 
945                 950                 955                 960 


Trp Tyr Asp Lys Asp Gly Arg Leu Leu Gln Glu Phe Asn Lys Ile Glu 
                965                 970                 975     


Pro Pro Leu Ile Phe Glu Cys Asn Gln Ala Cys Ser Cys Trp Arg Asn 
            980                 985                 990         


Cys Lys Asn Arg Val Val Gln Ser  Gly Ile Lys Val Arg  Leu Gln Leu 
        995                 1000                 1005             


Tyr Arg  Thr Ala Lys Met Gly  Trp Gly Val Arg Ala  Leu Gln Thr 
    1010                 1015                 1020             


Ile Pro  Gln Gly Thr Phe Ile  Cys Glu Tyr Val Gly  Glu Leu Ile 
    1025                 1030                 1035             


Ser Asp  Ala Glu Ala Asp Val  Arg Glu Asp Asp Ser  Tyr Leu Phe 
    1040                 1045                 1050             


Asp Leu  Asp Asn Lys Asp Gly  Glu Val Tyr Cys Ile  Asp Ala Arg 
    1055                 1060                 1065             


Tyr Tyr  Gly Asn Ile Ser Arg  Phe Ile Asn His Leu  Cys Asp Pro 
    1070                 1075                 1080             


Asn Ile  Ile Pro Val Arg Val  Phe Met Leu His Gln  Asp Leu Arg 
    1085                 1090                 1095             


Phe Pro  Arg Ile Ala Phe Phe  Ser Ser Arg Asp Ile  Arg Thr Gly 
    1100                 1105                 1110             


Glu Glu  Leu Gly Phe Asp Tyr  Gly Asp Arg Phe Trp  Asp Ile Lys 
    1115                 1120                 1125             


Ser Lys  Tyr Phe Thr Cys Gln  Cys Gly Ser Glu Lys  Cys Lys His 
    1130                 1135                 1140             


Ser Ala  Glu Ala Ile Ala Leu  Glu Gln Ser Arg Leu  Ala Arg Leu 
    1145                 1150                 1155             


Asp Pro  His Pro Glu Leu Leu  Pro Glu Leu Gly Ser  Leu Pro Pro 
    1160                 1165                 1170             


Val Asn  Thr 
    1175     


<210>  4663
<211>  1210
<212>  PRT
<213>  Homo Sapiens

<400>  4663

Met Ala Ala Ala Ala Gly Ala Ala Ala Ala Ala Ala Ala Glu Gly Glu 
1               5                   10                  15      


Ala Pro Ala Glu Met Gly Ala Leu Leu Leu Glu Lys Glu Thr Arg Gly 
            20                  25                  30          


Ala Thr Glu Arg Val His Gly Ser Leu Gly Asp Thr Pro Arg Ser Glu 
        35                  40                  45              


Glu Thr Leu Pro Lys Ala Thr Pro Asp Ser Leu Glu Pro Ala Gly Pro 
    50                  55                  60                  


Ser Ser Pro Ala Ser Val Thr Val Thr Val Gly Asp Glu Gly Ala Asp 
65                  70                  75                  80  


Thr Pro Val Gly Ala Thr Pro Leu Ile Gly Asp Glu Ser Glu Asn Leu 
                85                  90                  95      


Glu Gly Asp Gly Asp Leu Arg Gly Gly Arg Ile Leu Leu Gly His Ala 
            100                 105                 110         


Thr Lys Ser Phe Pro Ser Ser Pro Ser Lys Gly Gly Ser Cys Pro Ser 
        115                 120                 125             


Arg Ala Lys Met Ser Met Thr Gly Ala Gly Lys Ser Pro Pro Ser Val 
    130                 135                 140                 


Gln Ser Leu Ala Met Arg Leu Leu Ser Met Pro Gly Ala Gln Gly Ala 
145                 150                 155                 160 


Ala Ala Ala Gly Ser Glu Pro Pro Pro Ala Thr Thr Ser Pro Glu Gly 
                165                 170                 175     


Gln Pro Lys Val His Arg Ala Arg Lys Thr Met Ser Lys Pro Gly Asn 
            180                 185                 190         


Gly Gln Pro Pro Val Pro Glu Lys Arg Pro Pro Glu Ile Gln His Phe 
        195                 200                 205             


Arg Met Ser Asp Asp Val His Ser Leu Gly Lys Val Thr Ser Asp Leu 
    210                 215                 220                 


Ala Lys Arg Arg Lys Leu Asn Ser Gly Gly Gly Leu Ser Glu Glu Leu 
225                 230                 235                 240 


Gly Ser Ala Arg Arg Ser Gly Glu Val Thr Leu Thr Lys Gly Asp Pro 
                245                 250                 255     


Gly Ser Leu Glu Glu Trp Glu Thr Val Val Gly Asp Asp Phe Ser Leu 
            260                 265                 270         


Tyr Tyr Asp Ser Tyr Ser Val Asp Glu Arg Val Asp Ser Asp Ser Lys 
        275                 280                 285             


Ser Glu Val Glu Ala Leu Thr Glu Gln Leu Ser Glu Glu Glu Glu Glu 
    290                 295                 300                 


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
305                 310                 315                 320 


Glu Glu Glu Asp Glu Glu Ser Gly Asn Gln Ser Asp Arg Ser Gly Ser 
                325                 330                 335     


Ser Gly Arg Arg Lys Ala Lys Lys Lys Trp Arg Lys Asp Ser Pro Trp 
            340                 345                 350         


Val Lys Pro Ser Arg Lys Arg Arg Lys Arg Glu Pro Pro Arg Ala Lys 
        355                 360                 365             


Glu Pro Arg Gly Val Asn Gly Val Gly Ser Ser Gly Pro Ser Glu Tyr 
    370                 375                 380                 


Met Glu Val Pro Leu Gly Ser Leu Glu Leu Pro Ser Glu Gly Thr Leu 
385                 390                 395                 400 


Ser Pro Asn His Ala Gly Val Ser Asn Asp Thr Ser Ser Leu Glu Thr 
                405                 410                 415     


Glu Arg Gly Phe Glu Glu Leu Pro Leu Cys Ser Cys Arg Met Glu Ala 
            420                 425                 430         


Pro Lys Ile Asp Arg Ile Ser Glu Arg Ala Gly His Lys Cys Met Ala 
        435                 440                 445             


Thr Glu Ser Val Asp Gly Glu Leu Ser Gly Cys Asn Ala Ala Ile Leu 
    450                 455                 460                 


Lys Arg Glu Thr Met Arg Pro Ser Ser Arg Val Ala Leu Met Val Leu 
465                 470                 475                 480 


Cys Glu Thr His Arg Ala Arg Met Val Lys His His Cys Cys Pro Gly 
                485                 490                 495     


Cys Gly Tyr Phe Cys Thr Ala Gly Thr Phe Leu Glu Cys His Pro Asp 
            500                 505                 510         


Phe Arg Val Ala His Arg Phe His Lys Ala Cys Val Ser Gln Leu Asn 
        515                 520                 525             


Gly Met Val Phe Cys Pro His Cys Gly Glu Asp Ala Ser Glu Ala Gln 
    530                 535                 540                 


Glu Val Thr Ile Pro Arg Gly Asp Gly Val Thr Pro Pro Ala Gly Thr 
545                 550                 555                 560 


Ala Ala Pro Ala Pro Pro Pro Leu Ser Gln Asp Val Pro Gly Arg Ala 
                565                 570                 575     


Asp Thr Ser Gln Pro Ser Ala Arg Met Arg Gly His Gly Glu Pro Arg 
            580                 585                 590         


Arg Pro Pro Cys Asp Pro Leu Ala Asp Thr Ile Asp Ser Ser Gly Pro 
        595                 600                 605             


Ser Leu Thr Leu Pro Asn Gly Gly Cys Leu Ser Ala Val Gly Leu Pro 
    610                 615                 620                 


Leu Gly Pro Gly Arg Glu Ala Leu Glu Lys Ala Leu Val Ile Gln Glu 
625                 630                 635                 640 


Ser Glu Arg Arg Lys Lys Leu Arg Phe His Pro Arg Gln Leu Tyr Leu 
                645                 650                 655     


Ser Val Lys Gln Gly Glu Leu Gln Lys Val Ile Leu Met Leu Leu Asp 
            660                 665                 670         


Asn Leu Asp Pro Asn Phe Gln Ser Asp Gln Gln Ser Lys Arg Thr Pro 
        675                 680                 685             


Leu His Ala Ala Ala Gln Lys Gly Ser Val Glu Ile Cys His Val Leu 
    690                 695                 700                 


Leu Gln Ala Gly Ala Asn Ile Asn Ala Val Asp Lys Gln Gln Arg Thr 
705                 710                 715                 720 


Pro Leu Met Glu Ala Val Val Asn Asn His Leu Glu Val Ala Arg Tyr 
                725                 730                 735     


Met Val Gln Arg Gly Gly Cys Val Tyr Ser Lys Glu Glu Asp Gly Ser 
            740                 745                 750         


Thr Cys Leu His His Ala Ala Lys Ile Gly Asn Leu Glu Met Val Ser 
        755                 760                 765             


Leu Leu Leu Ser Thr Gly Gln Val Asp Val Asn Ala Gln Asp Ser Gly 
    770                 775                 780                 


Gly Trp Thr Pro Ile Ile Trp Ala Ala Glu His Lys His Ile Glu Val 
785                 790                 795                 800 


Ile Arg Met Leu Leu Thr Arg Gly Ala Asp Val Thr Leu Thr Asp Asn 
                805                 810                 815     


Glu Glu Asn Ile Cys Leu His Trp Ala Ser Phe Thr Gly Ser Ala Ala 
            820                 825                 830         


Ile Ala Glu Val Leu Leu Asn Ala Arg Cys Asp Leu His Ala Val Asn 
        835                 840                 845             


Tyr His Gly Asp Thr Pro Leu His Ile Ala Ala Arg Glu Ser Tyr His 
    850                 855                 860                 


Asp Cys Val Leu Leu Phe Leu Ser Arg Gly Ala Asn Pro Glu Leu Arg 
865                 870                 875                 880 


Asn Lys Glu Gly Asp Thr Ala Trp Asp Leu Thr Pro Glu Arg Ser Asp 
                885                 890                 895     


Val Trp Phe Ala Leu Gln Leu Asn Arg Lys Leu Arg Leu Gly Val Gly 
            900                 905                 910         


Asn Arg Ala Ile Arg Thr Glu Lys Ile Ile Cys Arg Asp Val Ala Arg 
        915                 920                 925             


Gly Tyr Glu Asn Val Pro Ile Pro Cys Val Asn Gly Val Asp Gly Glu 
    930                 935                 940                 


Pro Cys Pro Glu Asp Tyr Lys Tyr Ile Ser Glu Asn Cys Glu Thr Ser 
945                 950                 955                 960 


Thr Met Asn Ile Asp Arg Asn Ile Thr His Leu Gln His Cys Thr Cys 
                965                 970                 975     


Val Asp Asp Cys Ser Ser Ser Asn Cys Leu Cys Gly Gln Leu Ser Ile 
            980                 985                 990         


Arg Cys Trp Tyr Asp Lys Asp Gly  Arg Leu Leu Gln Glu  Phe Asn Lys 
        995                 1000                 1005             


Ile Glu  Pro Pro Leu Ile Phe  Glu Cys Asn Gln Ala  Cys Ser Cys 
    1010                 1015                 1020             


Trp Arg  Asn Cys Lys Asn Arg  Val Val Gln Ser Gly  Ile Lys Val 
    1025                 1030                 1035             


Arg Leu  Gln Leu Tyr Arg Thr  Ala Lys Met Gly Trp  Gly Val Arg 
    1040                 1045                 1050             


Ala Leu  Gln Thr Ile Pro Gln  Gly Thr Phe Ile Cys  Glu Tyr Val 
    1055                 1060                 1065             


Gly Glu  Leu Ile Ser Asp Ala  Glu Ala Asp Val Arg  Glu Asp Asp 
    1070                 1075                 1080             


Ser Tyr  Leu Phe Asp Leu Asp  Asn Lys Asp Gly Glu  Val Tyr Cys 
    1085                 1090                 1095             


Ile Asp  Ala Arg Tyr Tyr Gly  Asn Ile Ser Arg Phe  Ile Asn His 
    1100                 1105                 1110             


Leu Cys  Asp Pro Asn Ile Ile  Pro Val Arg Val Phe  Met Leu His 
    1115                 1120                 1125             


Gln Asp  Leu Arg Phe Pro Arg  Ile Ala Phe Phe Ser  Ser Arg Asp 
    1130                 1135                 1140             


Ile Arg  Thr Gly Glu Glu Leu  Gly Phe Asp Tyr Gly  Asp Arg Phe 
    1145                 1150                 1155             


Trp Asp  Ile Lys Ser Lys Tyr  Phe Thr Cys Gln Cys  Gly Ser Glu 
    1160                 1165                 1170             


Lys Cys  Lys His Ser Ala Glu  Ala Ile Ala Leu Glu  Gln Ser Arg 
    1175                 1180                 1185             


Leu Ala  Arg Leu Asp Pro His  Pro Glu Leu Leu Pro  Glu Leu Gly 
    1190                 1195                 1200             


Ser Leu  Pro Pro Val Asn Thr  
    1205                 1210 


<210>  4664
<211>  1233
<212>  PRT
<213>  Homo Sapiens

<400>  4664

Met Arg Gly Leu Pro Arg Gly Arg Gly Leu Met Arg Ala Arg Gly Arg 
1               5                   10                  15      


Gly Arg Ala Ala Pro Pro Gly Ser Arg Gly Arg Gly Arg Gly Gly Pro 
            20                  25                  30          


His Arg Gly Arg Gly Arg Pro Arg Ser Leu Leu Ser Leu Pro Arg Ala 
        35                  40                  45              


Gln Ala Ser Trp Thr Pro Gln Leu Ser Thr Gly Leu Thr Ser Pro Pro 
    50                  55                  60                  


Val Pro Cys Leu Pro Ser Gln Gly Glu Ala Pro Ala Glu Met Gly Ala 
65                  70                  75                  80  


Leu Leu Leu Glu Lys Glu Thr Arg Gly Ala Thr Glu Arg Val His Gly 
                85                  90                  95      


Ser Leu Gly Asp Thr Pro Arg Ser Glu Glu Thr Leu Pro Lys Ala Thr 
            100                 105                 110         


Pro Asp Ser Leu Glu Pro Ala Gly Pro Ser Ser Pro Ala Ser Val Thr 
        115                 120                 125             


Val Thr Val Gly Asp Glu Gly Ala Asp Thr Pro Val Gly Ala Thr Pro 
    130                 135                 140                 


Leu Ile Gly Asp Glu Ser Glu Asn Leu Glu Gly Asp Gly Asp Leu Arg 
145                 150                 155                 160 


Gly Gly Arg Ile Leu Leu Gly His Ala Thr Lys Ser Phe Pro Ser Ser 
                165                 170                 175     


Pro Ser Lys Gly Gly Ser Cys Pro Ser Arg Ala Lys Met Ser Met Thr 
            180                 185                 190         


Gly Ala Gly Lys Ser Pro Pro Ser Val Gln Ser Leu Ala Met Arg Leu 
        195                 200                 205             


Leu Ser Met Pro Gly Ala Gln Gly Ala Ala Ala Ala Gly Ser Glu Pro 
    210                 215                 220                 


Pro Pro Ala Thr Thr Ser Pro Glu Gly Gln Pro Lys Val His Arg Ala 
225                 230                 235                 240 


Arg Lys Thr Met Ser Lys Pro Gly Asn Gly Gln Pro Pro Val Pro Glu 
                245                 250                 255     


Lys Arg Pro Pro Glu Ile Gln His Phe Arg Met Ser Asp Asp Val His 
            260                 265                 270         


Ser Leu Gly Lys Val Thr Ser Asp Leu Ala Lys Arg Arg Lys Leu Asn 
        275                 280                 285             


Ser Gly Gly Gly Leu Ser Glu Glu Leu Gly Ser Ala Arg Arg Ser Gly 
    290                 295                 300                 


Glu Val Thr Leu Thr Lys Gly Asp Pro Gly Ser Leu Glu Glu Trp Glu 
305                 310                 315                 320 


Thr Val Val Gly Asp Asp Phe Ser Leu Tyr Tyr Asp Ser Tyr Ser Val 
                325                 330                 335     


Asp Glu Arg Val Asp Ser Asp Ser Lys Ser Glu Val Glu Ala Leu Thr 
            340                 345                 350         


Glu Gln Leu Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
        355                 360                 365             


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Glu Ser 
    370                 375                 380                 


Gly Asn Gln Ser Asp Arg Ser Gly Ser Ser Gly Arg Arg Lys Ala Lys 
385                 390                 395                 400 


Lys Lys Trp Arg Lys Asp Ser Pro Trp Val Lys Pro Ser Arg Lys Arg 
                405                 410                 415     


Arg Lys Arg Glu Pro Pro Arg Ala Lys Glu Pro Arg Gly Val Ser Asn 
            420                 425                 430         


Asp Thr Ser Ser Leu Glu Thr Glu Arg Gly Phe Glu Glu Leu Pro Leu 
        435                 440                 445             


Cys Ser Cys Arg Met Glu Ala Pro Lys Ile Asp Arg Ile Ser Glu Arg 
    450                 455                 460                 


Ala Gly His Lys Cys Met Ala Thr Glu Ser Val Asp Gly Glu Leu Ser 
465                 470                 475                 480 


Gly Cys Asn Ala Ala Ile Leu Lys Arg Glu Thr Met Arg Pro Ser Ser 
                485                 490                 495     


Arg Val Ala Leu Met Val Leu Cys Glu Thr His Arg Ala Arg Met Val 
            500                 505                 510         


Lys His His Cys Cys Pro Gly Cys Gly Tyr Phe Cys Thr Ala Gly Thr 
        515                 520                 525             


Phe Leu Glu Cys His Pro Asp Phe Arg Val Ala His Arg Phe His Lys 
    530                 535                 540                 


Ala Cys Val Ser Gln Leu Asn Gly Met Val Phe Cys Pro His Cys Gly 
545                 550                 555                 560 


Glu Asp Ala Ser Glu Ala Gln Glu Val Thr Ile Pro Arg Gly Asp Gly 
                565                 570                 575     


Val Thr Pro Pro Ala Gly Thr Ala Ala Pro Ala Pro Pro Pro Leu Ser 
            580                 585                 590         


Gln Asp Val Pro Gly Arg Ala Asp Thr Ser Gln Pro Ser Ala Arg Met 
        595                 600                 605             


Arg Gly His Gly Glu Pro Arg Arg Pro Pro Cys Asp Pro Leu Ala Asp 
    610                 615                 620                 


Thr Ile Asp Ser Ser Gly Pro Ser Leu Thr Leu Pro Asn Gly Gly Cys 
625                 630                 635                 640 


Leu Ser Ala Val Gly Leu Pro Leu Gly Pro Gly Arg Glu Ala Leu Glu 
                645                 650                 655     


Lys Ala Leu Val Ile Gln Glu Ser Glu Arg Arg Lys Lys Leu Arg Phe 
            660                 665                 670         


His Pro Arg Gln Leu Tyr Leu Ser Val Lys Gln Gly Glu Leu Gln Lys 
        675                 680                 685             


Val Ile Leu Met Leu Leu Asp Asn Leu Asp Pro Asn Phe Gln Ser Asp 
    690                 695                 700                 


Gln Gln Ser Lys Arg Thr Pro Leu His Ala Ala Ala Gln Lys Gly Ser 
705                 710                 715                 720 


Val Glu Ile Cys His Val Leu Leu Gln Ala Gly Ala Asn Ile Asn Ala 
                725                 730                 735     


Val Asp Lys Gln Gln Arg Thr Pro Leu Met Glu Ala Val Val Asn Asn 
            740                 745                 750         


His Leu Glu Val Ala Arg Tyr Met Val Gln Arg Gly Gly Cys Val Tyr 
        755                 760                 765             


Ser Lys Glu Glu Asp Gly Ser Thr Cys Leu His His Ala Ala Lys Ile 
    770                 775                 780                 


Gly Asn Leu Glu Met Val Ser Leu Leu Leu Ser Thr Gly Gln Val Asp 
785                 790                 795                 800 


Val Asn Ala Gln Asp Ser Gly Gly Trp Thr Pro Ile Ile Trp Ala Ala 
                805                 810                 815     


Glu His Lys His Ile Glu Val Ile Arg Met Leu Leu Thr Arg Gly Ala 
            820                 825                 830         


Asp Val Thr Leu Thr Asp Asn Glu Glu Asn Ile Cys Leu His Trp Ala 
        835                 840                 845             


Ser Phe Thr Gly Ser Ala Ala Ile Ala Glu Val Leu Leu Asn Ala Arg 
    850                 855                 860                 


Cys Asp Leu His Ala Val Asn Tyr His Gly Asp Thr Pro Leu His Ile 
865                 870                 875                 880 


Ala Ala Arg Glu Ser Tyr His Asp Cys Val Leu Leu Phe Leu Ser Arg 
                885                 890                 895     


Gly Ala Asn Pro Glu Leu Arg Asn Lys Glu Gly Asp Thr Ala Trp Asp 
            900                 905                 910         


Leu Thr Pro Glu Arg Ser Asp Val Trp Phe Ala Leu Gln Leu Asn Arg 
        915                 920                 925             


Lys Leu Arg Leu Gly Val Gly Asn Arg Ala Ile Arg Thr Glu Lys Ile 
    930                 935                 940                 


Ile Cys Arg Asp Val Ala Arg Gly Tyr Glu Asn Val Pro Ile Pro Cys 
945                 950                 955                 960 


Val Asn Gly Val Asp Gly Glu Pro Cys Pro Glu Asp Tyr Lys Tyr Ile 
                965                 970                 975     


Ser Glu Asn Cys Glu Thr Ser Thr Met Asn Ile Asp Arg Asn Ile Thr 
            980                 985                 990         


His Leu Gln His Cys Thr Cys Val  Asp Asp Cys Ser Ser  Ser Asn Cys 
        995                 1000                 1005             


Leu Cys  Gly Gln Leu Ser Ile  Arg Cys Trp Tyr Asp  Lys Asp Gly 
    1010                 1015                 1020             


Arg Leu  Leu Gln Glu Phe Asn  Lys Ile Glu Pro Pro  Leu Ile Phe 
    1025                 1030                 1035             


Glu Cys  Asn Gln Ala Cys Ser  Cys Trp Arg Asn Cys  Lys Asn Arg 
    1040                 1045                 1050             


Val Val  Gln Ser Gly Ile Lys  Val Arg Leu Gln Leu  Tyr Arg Thr 
    1055                 1060                 1065             


Ala Lys  Met Gly Trp Gly Val  Arg Ala Leu Gln Thr  Ile Pro Gln 
    1070                 1075                 1080             


Gly Thr  Phe Ile Cys Glu Tyr  Val Gly Glu Leu Ile  Ser Asp Ala 
    1085                 1090                 1095             


Glu Ala  Asp Val Arg Glu Asp  Asp Ser Tyr Leu Phe  Asp Leu Asp 
    1100                 1105                 1110             


Asn Lys  Asp Gly Glu Val Tyr  Cys Ile Asp Ala Arg  Tyr Tyr Gly 
    1115                 1120                 1125             


Asn Ile  Ser Arg Phe Ile Asn  His Leu Cys Asp Pro  Asn Ile Ile 
    1130                 1135                 1140             


Pro Val  Arg Val Phe Met Leu  His Gln Asp Leu Arg  Phe Pro Arg 
    1145                 1150                 1155             


Ile Ala  Phe Phe Ser Ser Arg  Asp Ile Arg Thr Gly  Glu Glu Leu 
    1160                 1165                 1170             


Gly Phe  Asp Tyr Gly Asp Arg  Phe Trp Asp Ile Lys  Ser Lys Tyr 
    1175                 1180                 1185             


Phe Thr  Cys Gln Cys Gly Ser  Glu Lys Cys Lys His  Ser Ala Glu 
    1190                 1195                 1200             


Ala Ile  Ala Leu Glu Gln Ser  Arg Leu Ala Arg Leu  Asp Pro His 
    1205                 1210                 1215             


Pro Glu  Leu Leu Pro Glu Leu  Gly Ser Leu Pro Pro  Val Asn Thr 
    1220                 1225                 1230             


<210>  4665
<211>  1267
<212>  PRT
<213>  Homo Sapiens

<400>  4665

Met Arg Gly Leu Pro Arg Gly Arg Gly Leu Met Arg Ala Arg Gly Arg 
1               5                   10                  15      


Gly Arg Ala Ala Pro Pro Gly Ser Arg Gly Arg Gly Arg Gly Gly Pro 
            20                  25                  30          


His Arg Gly Arg Gly Arg Pro Arg Ser Leu Leu Ser Leu Pro Arg Ala 
        35                  40                  45              


Gln Ala Ser Trp Thr Pro Gln Leu Ser Thr Gly Leu Thr Ser Pro Pro 
    50                  55                  60                  


Val Pro Cys Leu Pro Ser Gln Gly Glu Ala Pro Ala Glu Met Gly Ala 
65                  70                  75                  80  


Leu Leu Leu Glu Lys Glu Thr Arg Gly Ala Thr Glu Arg Val His Gly 
                85                  90                  95      


Ser Leu Gly Asp Thr Pro Arg Ser Glu Glu Thr Leu Pro Lys Ala Thr 
            100                 105                 110         


Pro Asp Ser Leu Glu Pro Ala Gly Pro Ser Ser Pro Ala Ser Val Thr 
        115                 120                 125             


Val Thr Val Gly Asp Glu Gly Ala Asp Thr Pro Val Gly Ala Thr Pro 
    130                 135                 140                 


Leu Ile Gly Asp Glu Ser Glu Asn Leu Glu Gly Asp Gly Asp Leu Arg 
145                 150                 155                 160 


Gly Gly Arg Ile Leu Leu Gly His Ala Thr Lys Ser Phe Pro Ser Ser 
                165                 170                 175     


Pro Ser Lys Gly Gly Ser Cys Pro Ser Arg Ala Lys Met Ser Met Thr 
            180                 185                 190         


Gly Ala Gly Lys Ser Pro Pro Ser Val Gln Ser Leu Ala Met Arg Leu 
        195                 200                 205             


Leu Ser Met Pro Gly Ala Gln Gly Ala Ala Ala Ala Gly Ser Glu Pro 
    210                 215                 220                 


Pro Pro Ala Thr Thr Ser Pro Glu Gly Gln Pro Lys Val His Arg Ala 
225                 230                 235                 240 


Arg Lys Thr Met Ser Lys Pro Gly Asn Gly Gln Pro Pro Val Pro Glu 
                245                 250                 255     


Lys Arg Pro Pro Glu Ile Gln His Phe Arg Met Ser Asp Asp Val His 
            260                 265                 270         


Ser Leu Gly Lys Val Thr Ser Asp Leu Ala Lys Arg Arg Lys Leu Asn 
        275                 280                 285             


Ser Gly Gly Gly Leu Ser Glu Glu Leu Gly Ser Ala Arg Arg Ser Gly 
    290                 295                 300                 


Glu Val Thr Leu Thr Lys Gly Asp Pro Gly Ser Leu Glu Glu Trp Glu 
305                 310                 315                 320 


Thr Val Val Gly Asp Asp Phe Ser Leu Tyr Tyr Asp Ser Tyr Ser Val 
                325                 330                 335     


Asp Glu Arg Val Asp Ser Asp Ser Lys Ser Glu Val Glu Ala Leu Thr 
            340                 345                 350         


Glu Gln Leu Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
        355                 360                 365             


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Glu Ser 
    370                 375                 380                 


Gly Asn Gln Ser Asp Arg Ser Gly Ser Ser Gly Arg Arg Lys Ala Lys 
385                 390                 395                 400 


Lys Lys Trp Arg Lys Asp Ser Pro Trp Val Lys Pro Ser Arg Lys Arg 
                405                 410                 415     


Arg Lys Arg Glu Pro Pro Arg Ala Lys Glu Pro Arg Gly Val Asn Gly 
            420                 425                 430         


Val Gly Ser Ser Gly Pro Ser Glu Tyr Met Glu Val Pro Leu Gly Ser 
        435                 440                 445             


Leu Glu Leu Pro Ser Glu Gly Thr Leu Ser Pro Asn His Ala Gly Val 
    450                 455                 460                 


Ser Asn Asp Thr Ser Ser Leu Glu Thr Glu Arg Gly Phe Glu Glu Leu 
465                 470                 475                 480 


Pro Leu Cys Ser Cys Arg Met Glu Ala Pro Lys Ile Asp Arg Ile Ser 
                485                 490                 495     


Glu Arg Ala Gly His Lys Cys Met Ala Thr Glu Ser Val Asp Gly Glu 
            500                 505                 510         


Leu Ser Gly Cys Asn Ala Ala Ile Leu Lys Arg Glu Thr Met Arg Pro 
        515                 520                 525             


Ser Ser Arg Val Ala Leu Met Val Leu Cys Glu Thr His Arg Ala Arg 
    530                 535                 540                 


Met Val Lys His His Cys Cys Pro Gly Cys Gly Tyr Phe Cys Thr Ala 
545                 550                 555                 560 


Gly Thr Phe Leu Glu Cys His Pro Asp Phe Arg Val Ala His Arg Phe 
                565                 570                 575     


His Lys Ala Cys Val Ser Gln Leu Asn Gly Met Val Phe Cys Pro His 
            580                 585                 590         


Cys Gly Glu Asp Ala Ser Glu Ala Gln Glu Val Thr Ile Pro Arg Gly 
        595                 600                 605             


Asp Gly Val Thr Pro Pro Ala Gly Thr Ala Ala Pro Ala Pro Pro Pro 
    610                 615                 620                 


Leu Ser Gln Asp Val Pro Gly Arg Ala Asp Thr Ser Gln Pro Ser Ala 
625                 630                 635                 640 


Arg Met Arg Gly His Gly Glu Pro Arg Arg Pro Pro Cys Asp Pro Leu 
                645                 650                 655     


Ala Asp Thr Ile Asp Ser Ser Gly Pro Ser Leu Thr Leu Pro Asn Gly 
            660                 665                 670         


Gly Cys Leu Ser Ala Val Gly Leu Pro Leu Gly Pro Gly Arg Glu Ala 
        675                 680                 685             


Leu Glu Lys Ala Leu Val Ile Gln Glu Ser Glu Arg Arg Lys Lys Leu 
    690                 695                 700                 


Arg Phe His Pro Arg Gln Leu Tyr Leu Ser Val Lys Gln Gly Glu Leu 
705                 710                 715                 720 


Gln Lys Val Ile Leu Met Leu Leu Asp Asn Leu Asp Pro Asn Phe Gln 
                725                 730                 735     


Ser Asp Gln Gln Ser Lys Arg Thr Pro Leu His Ala Ala Ala Gln Lys 
            740                 745                 750         


Gly Ser Val Glu Ile Cys His Val Leu Leu Gln Ala Gly Ala Asn Ile 
        755                 760                 765             


Asn Ala Val Asp Lys Gln Gln Arg Thr Pro Leu Met Glu Ala Val Val 
    770                 775                 780                 


Asn Asn His Leu Glu Val Ala Arg Tyr Met Val Gln Arg Gly Gly Cys 
785                 790                 795                 800 


Val Tyr Ser Lys Glu Glu Asp Gly Ser Thr Cys Leu His His Ala Ala 
                805                 810                 815     


Lys Ile Gly Asn Leu Glu Met Val Ser Leu Leu Leu Ser Thr Gly Gln 
            820                 825                 830         


Val Asp Val Asn Ala Gln Asp Ser Gly Gly Trp Thr Pro Ile Ile Trp 
        835                 840                 845             


Ala Ala Glu His Lys His Ile Glu Val Ile Arg Met Leu Leu Thr Arg 
    850                 855                 860                 


Gly Ala Asp Val Thr Leu Thr Asp Asn Glu Glu Asn Ile Cys Leu His 
865                 870                 875                 880 


Trp Ala Ser Phe Thr Gly Ser Ala Ala Ile Ala Glu Val Leu Leu Asn 
                885                 890                 895     


Ala Arg Cys Asp Leu His Ala Val Asn Tyr His Gly Asp Thr Pro Leu 
            900                 905                 910         


His Ile Ala Ala Arg Glu Ser Tyr His Asp Cys Val Leu Leu Phe Leu 
        915                 920                 925             


Ser Arg Gly Ala Asn Pro Glu Leu Arg Asn Lys Glu Gly Asp Thr Ala 
    930                 935                 940                 


Trp Asp Leu Thr Pro Glu Arg Ser Asp Val Trp Phe Ala Leu Gln Leu 
945                 950                 955                 960 


Asn Arg Lys Leu Arg Leu Gly Val Gly Asn Arg Ala Ile Arg Thr Glu 
                965                 970                 975     


Lys Ile Ile Cys Arg Asp Val Ala Arg Gly Tyr Glu Asn Val Pro Ile 
            980                 985                 990         


Pro Cys Val Asn Gly Val Asp Gly  Glu Pro Cys Pro Glu  Asp Tyr Lys 
        995                 1000                 1005             


Tyr Ile  Ser Glu Asn Cys Glu  Thr Ser Thr Met Asn  Ile Asp Arg 
    1010                 1015                 1020             


Asn Ile  Thr His Leu Gln His  Cys Thr Cys Val Asp  Asp Cys Ser 
    1025                 1030                 1035             


Ser Ser  Asn Cys Leu Cys Gly  Gln Leu Ser Ile Arg  Cys Trp Tyr 
    1040                 1045                 1050             


Asp Lys  Asp Gly Arg Leu Leu  Gln Glu Phe Asn Lys  Ile Glu Pro 
    1055                 1060                 1065             


Pro Leu  Ile Phe Glu Cys Asn  Gln Ala Cys Ser Cys  Trp Arg Asn 
    1070                 1075                 1080             


Cys Lys  Asn Arg Val Val Gln  Ser Gly Ile Lys Val  Arg Leu Gln 
    1085                 1090                 1095             


Leu Tyr  Arg Thr Ala Lys Met  Gly Trp Gly Val Arg  Ala Leu Gln 
    1100                 1105                 1110             


Thr Ile  Pro Gln Gly Thr Phe  Ile Cys Glu Tyr Val  Gly Glu Leu 
    1115                 1120                 1125             


Ile Ser  Asp Ala Glu Ala Asp  Val Arg Glu Asp Asp  Ser Tyr Leu 
    1130                 1135                 1140             


Phe Asp  Leu Asp Asn Lys Asp  Gly Glu Val Tyr Cys  Ile Asp Ala 
    1145                 1150                 1155             


Arg Tyr  Tyr Gly Asn Ile Ser  Arg Phe Ile Asn His  Leu Cys Asp 
    1160                 1165                 1170             


Pro Asn  Ile Ile Pro Val Arg  Val Phe Met Leu His  Gln Asp Leu 
    1175                 1180                 1185             


Arg Phe  Pro Arg Ile Ala Phe  Phe Ser Ser Arg Asp  Ile Arg Thr 
    1190                 1195                 1200             


Gly Glu  Glu Leu Gly Phe Asp  Tyr Gly Asp Arg Phe  Trp Asp Ile 
    1205                 1210                 1215             


Lys Ser  Lys Tyr Phe Thr Cys  Gln Cys Gly Ser Glu  Lys Cys Lys 
    1220                 1225                 1230             


His Ser  Ala Glu Ala Ile Ala  Leu Glu Gln Ser Arg  Leu Ala Arg 
    1235                 1240                 1245             


Leu Asp  Pro His Pro Glu Leu  Leu Pro Glu Leu Gly  Ser Leu Pro 
    1250                 1255                 1260             


Pro Val  Asn Thr 
    1265         


<210>  4666
<211>  298
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4666

Xaa Ser Lys Arg Thr Pro Leu His Ala Ala Ala Gln Lys Gly Ser Val 
1               5                   10                  15      


Glu Ile Cys His Val Leu Leu Gln Ala Gly Ala Asn Ile Asn Ala Val 
            20                  25                  30          


Asp Lys Gln Gln Arg Thr Pro Leu Met Glu Ala Val Val Asn Asn His 
        35                  40                  45              


Leu Glu Val Ala Arg Tyr Met Val Gln Arg Gly Gly Cys Val Tyr Ser 
    50                  55                  60                  


Lys Glu Glu Asp Gly Ser Thr Cys Leu His His Ala Ala Lys Ile Gly 
65                  70                  75                  80  


Asn Leu Glu Met Val Ser Leu Leu Leu Ser Thr Gly Gln Val Asp Val 
                85                  90                  95      


Asn Ala Gln Gly Gln Leu Pro Pro Pro Ser Leu Pro Ser His Pro Gln 
            100                 105                 110         


Asp Ser Gly Gly Trp Thr Pro Ile Ile Trp Ala Ala Glu His Lys His 
        115                 120                 125             


Ile Glu Val Ile Arg Met Leu Leu Thr Arg Gly Ala Asp Val Thr Leu 
    130                 135                 140                 


Thr Asp Asn Glu Glu Asn Ile Cys Leu His Trp Ala Ser Phe Thr Gly 
145                 150                 155                 160 


Ser Ala Ala Ile Ala Glu Val Leu Leu Asn Ala Arg Cys Asp Leu His 
                165                 170                 175     


Ala Val Asn Tyr His Gly Asp Thr Pro Leu His Ile Ala Ala Arg Glu 
            180                 185                 190         


Ser Tyr His Asp Cys Val Leu Leu Phe Leu Ser Arg Gly Ala Asn Pro 
        195                 200                 205             


Glu Leu Arg Asn Lys Glu Gly Asp Thr Ala Trp Asp Leu Thr Pro Glu 
    210                 215                 220                 


Arg Ser Asp Val Trp Phe Ala Leu Gln Leu Asn Arg Lys Leu Arg Leu 
225                 230                 235                 240 


Gly Val Gly Asn Arg Ala Ile Arg Thr Glu Lys Ile Ile Cys Arg Asp 
                245                 250                 255     


Val Ala Arg Gly Tyr Glu Asn Val Pro Ile Pro Cys Val Asn Gly Val 
            260                 265                 270         


Asp Gly Glu Pro Cys Pro Glu Asp Tyr Lys Tyr Ile Ser Glu Asn Cys 
        275                 280                 285             


Glu Thr Ser Thr Met Asn Ile Asp Arg Asn 
    290                 295             


<210>  4667
<211>  81
<212>  PRT
<213>  Homo Sapiens

<400>  4667

Met Gln Gly Gly Asn Ser Gly Val Arg Lys Arg Glu Glu Glu Gly Asp 
1               5                   10                  15      


Gly Ala Gly Ala Val Ala Ala Pro Pro Ala Ile Asp Phe Pro Ala Glu 
            20                  25                  30          


Gly Pro Asp Pro Glu Tyr Asp Glu Met Trp Ser Cys Cys Val Ser Gln 
        35                  40                  45              


Ala Gly Leu Glu Arg Leu Ala Ser Ser Asp Ser Pro Ala Ser Ala Phe 
    50                  55                  60                  


Gln Asn Ala Gly Ile Ile Asp Asn Leu Met Phe Gln Gln Lys Ser Arg 
65                  70                  75                  80  


Cys 
    


<210>  4668
<211>  164
<212>  PRT
<213>  Homo Sapiens

<400>  4668

Met Gln Gly Gly Asn Ser Gly Val Arg Lys Arg Glu Glu Glu Gly Asp 
1               5                   10                  15      


Gly Ala Gly Ala Val Ala Ala Pro Pro Ala Ile Asp Phe Pro Ala Glu 
            20                  25                  30          


Gly Pro Asp Pro Glu Tyr Asp Glu Ser Asp Val Pro Ala Glu Ile Gln 
        35                  40                  45              


Val Leu Lys Glu Pro Leu Gln Gln Pro Thr Phe Pro Phe Ala Val Ala 
    50                  55                  60                  


Asn Gln Leu Leu Leu Val Ser Leu Leu Glu His Leu Ser His Val His 
65                  70                  75                  80  


Glu Pro Asn Pro Leu Arg Ser Arg Gln Val Phe Lys Leu Leu Cys Gln 
                85                  90                  95      


Thr Phe Ile Lys Met Gly Leu Leu Ser Ser Phe Thr Cys Ser Asp Glu 
            100                 105                 110         


Phe Ser Ser Leu Arg Leu His His Asn Arg Ala Ile Thr His Leu Met 
        115                 120                 125             


Arg Ser Ala Lys Glu Arg Val Arg Gln Asp Pro Cys Glu Asp Ile Ser 
    130                 135                 140                 


Arg Ile Gln Lys Ile Arg Asp Glu Lys Phe His Phe Ser Pro Ser Phe 
145                 150                 155                 160 


Pro Asn Gln His 
                


<210>  4669
<211>  630
<212>  PRT
<213>  Homo Sapiens

<400>  4669

Met Gln Gly Gly Asn Ser Gly Val Arg Lys Arg Glu Glu Glu Gly Asp 
1               5                   10                  15      


Gly Ala Gly Ala Val Ala Ala Pro Pro Ala Ile Asp Phe Pro Ala Glu 
            20                  25                  30          


Gly Pro Asp Pro Glu Tyr Asp Glu Ser Asp Val Pro Ala Glu Ile Gln 
        35                  40                  45              


Val Leu Lys Glu Pro Leu Gln Gln Pro Thr Phe Pro Phe Ala Val Ala 
    50                  55                  60                  


Asn Gln Leu Leu Leu Val Ser Leu Leu Glu His Leu Ser His Val His 
65                  70                  75                  80  


Glu Pro Asn Pro Leu Arg Ser Arg Gln Val Phe Lys Leu Leu Cys Gln 
                85                  90                  95      


Thr Phe Ile Lys Met Gly Leu Leu Ser Ser Phe Thr Cys Ser Asp Glu 
            100                 105                 110         


Phe Ser Ser Leu Arg Leu His His Asn Arg Ala Ile Thr His Leu Met 
        115                 120                 125             


Arg Ser Ala Lys Glu Arg Val Arg Gln Asp Pro Cys Glu Asp Ile Ser 
    130                 135                 140                 


Arg Ile Gln Lys Ile Arg Ser Arg Glu Val Ala Leu Glu Ala Gln Thr 
145                 150                 155                 160 


Ser Arg Tyr Leu Asn Glu Phe Glu Glu Leu Ala Ile Leu Gly Lys Gly 
                165                 170                 175     


Gly Tyr Gly Arg Val Tyr Lys Val Arg Asn Lys Leu Asp Gly Gln Tyr 
            180                 185                 190         


Tyr Ala Ile Lys Lys Ile Leu Ile Lys Gly Ala Thr Lys Thr Val Cys 
        195                 200                 205             


Met Lys Val Leu Arg Glu Val Lys Val Leu Ala Gly Leu Gln His Pro 
    210                 215                 220                 


Asn Ile Val Gly Tyr His Thr Ala Trp Ile Glu His Val His Val Ile 
225                 230                 235                 240 


Gln Pro Arg Ala Asp Arg Ala Ala Ile Glu Leu Pro Ser Leu Glu Val 
                245                 250                 255     


Leu Ser Asp Gln Glu Glu Asp Arg Glu Gln Cys Gly Val Lys Asn Asp 
            260                 265                 270         


Glu Ser Ser Ser Ser Ser Ile Ile Phe Ala Glu Pro Thr Pro Glu Lys 
        275                 280                 285             


Glu Lys Arg Phe Gly Glu Ser Asp Thr Glu Asn Gln Asn Asn Lys Ser 
    290                 295                 300                 


Val Lys Tyr Thr Thr Asn Leu Val Ile Arg Glu Ser Gly Glu Leu Glu 
305                 310                 315                 320 


Ser Thr Leu Glu Leu Gln Glu Asn Gly Leu Ala Gly Leu Ser Ala Ser 
                325                 330                 335     


Ser Ile Val Glu Gln Gln Leu Pro Leu Arg Arg Asn Ser His Leu Glu 
            340                 345                 350         


Glu Ser Phe Thr Ser Thr Glu Glu Ser Ser Glu Glu Asn Val Asn Phe 
        355                 360                 365             


Leu Gly Gln Thr Glu Ala Gln Tyr His Leu Met Leu His Ile Gln Met 
    370                 375                 380                 


Gln Leu Cys Glu Leu Ser Leu Trp Asp Trp Ile Val Glu Arg Asn Lys 
385                 390                 395                 400 


Arg Gly Arg Glu Tyr Val Asp Glu Ser Ala Cys Pro Tyr Val Met Ala 
                405                 410                 415     


Asn Val Ala Thr Lys Ile Phe Gln Glu Leu Val Glu Gly Val Phe Tyr 
            420                 425                 430         


Ile His Asn Met Gly Ile Val His Arg Asp Leu Lys Pro Arg Asn Ile 
        435                 440                 445             


Phe Leu His Gly Pro Asp Gln Gln Val Lys Ile Gly Asp Phe Gly Leu 
    450                 455                 460                 


Ala Cys Thr Asp Ile Leu Gln Lys Asn Thr Asp Trp Thr Asn Arg Asn 
465                 470                 475                 480 


Gly Lys Arg Thr Pro Thr His Thr Ser Arg Val Gly Thr Cys Leu Tyr 
                485                 490                 495     


Ala Ser Pro Glu Gln Leu Glu Gly Ser Glu Tyr Asp Ala Lys Ser Asp 
            500                 505                 510         


Met Tyr Ser Leu Gly Val Val Leu Leu Glu Leu Phe Gln Pro Phe Gly 
        515                 520                 525             


Thr Glu Met Glu Arg Ala Glu Val Leu Thr Gly Leu Arg Thr Gly Gln 
    530                 535                 540                 


Leu Pro Glu Ser Leu Arg Lys Arg Cys Pro Val Gln Ala Lys Tyr Ile 
545                 550                 555                 560 


Gln His Leu Thr Arg Arg Asn Ser Ser Gln Arg Pro Ser Ala Ile Gln 
                565                 570                 575     


Leu Leu Gln Ser Glu Leu Phe Gln Asn Ser Gly Asn Val Asn Leu Thr 
            580                 585                 590         


Leu Gln Met Lys Ile Ile Glu Gln Glu Lys Glu Ile Ala Glu Leu Lys 
        595                 600                 605             


Lys Gln Leu Asn Leu Leu Ser Gln Asp Lys Gly Val Arg Asp Asp Gly 
    610                 615                 620                 


Lys Asp Gly Gly Val Gly 
625                 630 


<210>  4670
<211>  72
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4670

Xaa Leu Ala Gly Leu Thr Pro Leu Gly Val Ala Ala Val Ala Ser Ala 
1               5                   10                  15      


Gly Thr Gly Gly Ile Cys Trp Cys Ser Gln Arg Gly Ala Glu Gly Trp 
            20                  25                  30          


Gly Pro Thr Pro Gln Arg Arg Pro Val Asn Leu Thr Leu Gln Met Lys 
        35                  40                  45              


Ile Ile Glu Gln Glu Lys Glu Ile Ala Glu Leu Lys Lys Gln Leu Asn 
    50                  55                  60                  


Leu Leu Ser Gln Asp Lys Gly Ala 
65                  70          


<210>  4671
<211>  267
<212>  PRT
<213>  Homo Sapiens

<400>  4671

Met Thr Leu Gly Arg Arg Leu Ala Cys Leu Phe Leu Ala Cys Val Leu 
1               5                   10                  15      


Pro Ala Leu Leu Leu Gly Gly Thr Ala Leu Ala Ser Glu Ile Val Gly 
            20                  25                  30          


Gly Arg Arg Ala Arg Pro His Ala Trp Pro Phe Met Val Ser Leu Gln 
        35                  40                  45              


Leu Arg Gly Gly His Phe Cys Gly Ala Thr Leu Ile Ala Pro Asn Phe 
    50                  55                  60                  


Val Met Ser Ala Ala His Cys Val Ala Asn Val Asn Val Arg Ala Val 
65                  70                  75                  80  


Arg Val Val Leu Gly Ala His Asn Leu Ser Arg Arg Glu Pro Thr Arg 
                85                  90                  95      


Gln Val Phe Ala Val Gln Arg Ile Phe Glu Asn Gly Tyr Asp Pro Val 
            100                 105                 110         


Asn Leu Leu Asn Asp Ile Val Ile Leu Gln Leu Asn Gly Ser Ala Thr 
        115                 120                 125             


Ile Asn Ala Asn Val Gln Val Ala Gln Leu Pro Ala Gln Gly Arg Arg 
    130                 135                 140                 


Leu Gly Asn Gly Val Gln Cys Leu Ala Met Gly Trp Gly Leu Leu Gly 
145                 150                 155                 160 


Arg Asn Arg Gly Ile Ala Ser Val Leu Gln Glu Leu Asn Val Thr Val 
                165                 170                 175     


Val Thr Ser Leu Cys Arg Arg Ser Asn Val Cys Thr Leu Val Arg Gly 
            180                 185                 190         


Arg Gln Ala Gly Val Cys Phe Gly Asp Ser Gly Ser Pro Leu Val Cys 
        195                 200                 205             


Asn Gly Leu Ile His Gly Ile Ala Ser Phe Val Arg Gly Gly Cys Ala 
    210                 215                 220                 


Ser Gly Leu Tyr Pro Asp Ala Phe Ala Pro Val Ala Gln Phe Val Asn 
225                 230                 235                 240 


Trp Ile Asp Ser Ile Ile Gln Arg Ser Glu Asp Asn Pro Cys Pro His 
                245                 250                 255     


Pro Arg Asp Pro Asp Pro Ala Ser Arg Thr His 
            260                 265         


<210>  4672
<211>  267
<212>  PRT
<213>  Homo Sapiens

<400>  4672

Met Thr Leu Gly Arg Arg Leu Ala Cys Leu Phe Leu Ala Cys Val Leu 
1               5                   10                  15      


Pro Ala Leu Leu Leu Gly Gly Thr Ala Leu Ala Ser Glu Ile Val Gly 
            20                  25                  30          


Gly Arg Arg Ala Arg Pro His Ala Trp Pro Phe Met Val Ser Leu Gln 
        35                  40                  45              


Leu Arg Gly Gly His Phe Cys Gly Ala Thr Leu Ile Ala Pro Asn Phe 
    50                  55                  60                  


Val Met Ser Ala Ala His Cys Val Ala Asn Val Asn Val Arg Ala Val 
65                  70                  75                  80  


Arg Val Val Leu Gly Ala His Asn Leu Ser Arg Arg Glu Pro Thr Arg 
                85                  90                  95      


Gln Val Phe Ala Val Gln Arg Ile Phe Glu Asn Gly Tyr Asp Pro Val 
            100                 105                 110         


Asn Leu Leu Asn Asp Ile Val Ile Leu Gln Leu Asn Gly Ser Ala Thr 
        115                 120                 125             


Ile Asn Ala Asn Val Gln Val Ala Gln Leu Pro Ala Gln Gly Arg Arg 
    130                 135                 140                 


Leu Gly Asn Gly Val Gln Cys Leu Ala Met Gly Trp Gly Leu Leu Gly 
145                 150                 155                 160 


Arg Asn Arg Gly Ile Ala Ser Val Leu Gln Glu Leu Asn Val Thr Val 
                165                 170                 175     


Val Thr Ser Leu Cys Arg Arg Ser Asn Val Cys Thr Leu Val Arg Gly 
            180                 185                 190         


Arg Gln Ala Gly Val Cys Phe Gly Asp Ser Gly Ser Pro Leu Val Cys 
        195                 200                 205             


Asn Gly Leu Ile His Gly Ile Ala Ser Phe Val Arg Gly Gly Cys Ala 
    210                 215                 220                 


Ser Gly Leu Tyr Pro Asp Ala Phe Ala Pro Val Ala Gln Phe Val Asn 
225                 230                 235                 240 


Trp Ile Asp Ser Ile Ile Gln Arg Ser Glu Asp Asn Pro Cys Pro His 
                245                 250                 255     


Pro Arg Asp Pro Asp Pro Ala Ser Arg Thr His 
            260                 265         


<210>  4673
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  4673

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30          


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Ala Leu Gly Pro 
        35                  40                  45              


Gly Gly Lys Pro Leu Lys Pro Gly Leu Gly Ala Phe Pro Ala Val Thr 
    50                  55                  60                  


Phe Pro Gly Ala Leu Val Pro Gly Gly Val Ala Asp Ala Ala Ala Ala 
65                  70                  75                  80  


Tyr Lys Ala Ala Lys Ala Gly Ala Gly Leu Gly Gly Val Pro Gly Val 
                85                  90                  95      


Gly Gly Leu Gly Val Ser Ala Gly Ala Val Val Pro Gln Pro Gly Ala 
            100                 105                 110         


Gly Val Lys Pro Gly Lys Val Pro Gly Val Gly Leu Pro Gly Val Tyr 
        115                 120                 125             


Pro Gly Gly Val Leu Pro Gly Ala Arg Phe Pro Gly Val Gly Val Leu 
    130                 135                 140                 


Pro Gly Val Pro Thr Gly Ala Gly 
145                 150         


<210>  4674
<211>  700
<212>  PRT
<213>  Homo Sapiens

<400>  4674

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30          


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Ala Leu Gly Pro 
        35                  40                  45              


Gly Gly Lys Pro Leu Lys Pro Val Pro Gly Gly Leu Ala Gly Ala Gly 
    50                  55                  60                  


Leu Gly Ala Gly Leu Gly Ala Phe Pro Ala Val Thr Phe Pro Gly Ala 
65                  70                  75                  80  


Leu Val Pro Gly Gly Val Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala 
                85                  90                  95      


Lys Ala Gly Ala Gly Leu Gly Gly Val Pro Gly Val Gly Gly Leu Gly 
            100                 105                 110         


Val Ser Ala Ala Pro Ser Val Pro Gly Ala Val Val Pro Gln Pro Gly 
        115                 120                 125             


Ala Gly Val Lys Pro Gly Lys Val Pro Gly Val Gly Leu Pro Gly Val 
    130                 135                 140                 


Tyr Pro Gly Gly Val Leu Pro Gly Ala Arg Phe Pro Gly Val Gly Val 
145                 150                 155                 160 


Leu Pro Gly Val Pro Thr Gly Ala Gly Val Lys Pro Lys Ala Pro Gly 
                165                 170                 175     


Val Gly Gly Ala Phe Ala Gly Ile Pro Gly Val Gly Pro Phe Gly Gly 
            180                 185                 190         


Pro Gln Pro Gly Val Pro Leu Gly Tyr Pro Ile Lys Ala Pro Lys Leu 
        195                 200                 205             


Pro Gly Gly Tyr Gly Leu Pro Tyr Thr Thr Gly Lys Leu Pro Tyr Gly 
    210                 215                 220                 


Tyr Gly Pro Gly Gly Val Ala Gly Ala Ala Gly Lys Ala Gly Tyr Pro 
225                 230                 235                 240 


Thr Gly Thr Gly Val Gly Pro Gln Ala Ala Ala Ala Ala Ala Ala Lys 
                245                 250                 255     


Ala Ala Ala Lys Phe Gly Ala Gly Ala Ala Gly Val Leu Pro Gly Val 
            260                 265                 270         


Gly Gly Ala Gly Val Pro Gly Val Pro Gly Ala Ile Pro Gly Ile Gly 
        275                 280                 285             


Gly Ile Ala Gly Val Gly Thr Pro Ala Ala Ala Ala Ala Ala Ala Ala 
    290                 295                 300                 


Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Ala Gly Leu Val Pro Gly 
305                 310                 315                 320 


Gly Pro Gly Phe Gly Pro Gly Val Val Gly Val Pro Gly Ala Gly Val 
                325                 330                 335     


Pro Gly Val Gly Val Pro Gly Ala Gly Ile Pro Val Val Pro Gly Ala 
            340                 345                 350         


Gly Ile Pro Gly Ala Ala Val Pro Gly Val Val Ser Pro Glu Ala Ala 
        355                 360                 365             


Ala Lys Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Arg Pro Gly Val 
    370                 375                 380                 


Gly Val Gly Gly Ile Pro Thr Tyr Gly Val Gly Ala Gly Gly Phe Pro 
385                 390                 395                 400 


Gly Phe Gly Val Gly Val Gly Gly Ile Pro Gly Val Ala Gly Val Pro 
                405                 410                 415     


Gly Val Gly Gly Val Pro Gly Val Gly Gly Val Pro Gly Val Gly Ile 
            420                 425                 430         


Ser Pro Glu Ala Gln Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly 
        435                 440                 445             


Leu Val Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly 
    450                 455                 460                 


Val Gly Val Ala Pro Gly Val Gly Leu Ala Pro Gly Val Gly Val Ala 
465                 470                 475                 480 


Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Ile Gly 
                485                 490                 495     


Pro Gly Gly Val Ala Ala Ala Ala Lys Ser Ala Ala Lys Val Ala Ala 
            500                 505                 510         


Lys Ala Gln Leu Arg Ala Ala Ala Gly Leu Gly Ala Gly Ile Pro Gly 
        515                 520                 525             


Leu Gly Val Gly Val Gly Val Pro Gly Leu Gly Val Gly Ala Gly Val 
    530                 535                 540                 


Pro Gly Leu Gly Val Gly Ala Gly Val Pro Gly Phe Gly Ala Val Pro 
545                 550                 555                 560 


Gly Ala Leu Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Val Pro 
                565                 570                 575     


Gly Val Leu Gly Gly Leu Gly Ala Leu Gly Gly Val Gly Ile Pro Gly 
            580                 585                 590         


Gly Val Val Gly Ala Gly Pro Ala Ala Ala Ala Ala Ala Ala Lys Ala 
        595                 600                 605             


Ala Ala Lys Ala Ala Gln Phe Gly Leu Val Gly Ala Ala Gly Leu Gly 
    610                 615                 620                 


Gly Leu Gly Val Gly Gly Leu Gly Val Pro Gly Val Gly Gly Leu Gly 
625                 630                 635                 640 


Gly Ile Pro Pro Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala 
                645                 650                 655     


Gly Leu Gly Gly Val Leu Gly Gly Ala Gly Gln Phe Pro Leu Gly Gly 
            660                 665                 670         


Val Ala Ala Arg Pro Gly Phe Gly Leu Ser Pro Ile Phe Pro Gly Gly 
        675                 680                 685             


Ala Cys Leu Gly Lys Ala Cys Gly Arg Lys Arg Lys 
    690                 695                 700 


<210>  4675
<211>  677
<212>  PRT
<213>  Homo Sapiens

<400>  4675

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30          


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Ala Leu Gly Pro 
        35                  40                  45              


Gly Gly Lys Pro Leu Lys Pro Val Pro Gly Gly Leu Ala Gly Ala Gly 
    50                  55                  60                  


Leu Gly Ala Gly Leu Gly Ala Phe Pro Ala Val Thr Phe Pro Gly Ala 
65                  70                  75                  80  


Leu Val Pro Gly Gly Val Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala 
                85                  90                  95      


Lys Ala Gly Ala Gly Leu Gly Gly Val Pro Gly Val Gly Gly Leu Gly 
            100                 105                 110         


Val Ser Ala Gly Ala Val Val Pro Gln Pro Gly Ala Gly Val Lys Pro 
        115                 120                 125             


Gly Lys Val Pro Gly Val Gly Leu Pro Gly Val Tyr Pro Gly Gly Val 
    130                 135                 140                 


Leu Pro Gly Ala Arg Phe Pro Gly Val Gly Val Leu Pro Gly Val Pro 
145                 150                 155                 160 


Thr Gly Ala Gly Val Lys Pro Lys Ala Pro Gly Val Gly Gly Ala Phe 
                165                 170                 175     


Ala Gly Ile Pro Gly Val Gly Pro Phe Gly Gly Pro Gln Pro Gly Val 
            180                 185                 190         


Pro Leu Gly Tyr Pro Ile Lys Ala Pro Lys Leu Pro Gly Gly Tyr Gly 
        195                 200                 205             


Leu Pro Tyr Thr Thr Gly Lys Leu Pro Tyr Gly Tyr Gly Pro Gly Gly 
    210                 215                 220                 


Val Ala Gly Ala Ala Gly Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val 
225                 230                 235                 240 


Gly Pro Gln Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Phe 
                245                 250                 255     


Gly Ala Gly Ala Ala Gly Val Leu Pro Gly Val Gly Gly Ala Gly Val 
            260                 265                 270         


Pro Gly Val Pro Gly Ala Ile Pro Gly Ile Gly Gly Ile Ala Gly Val 
        275                 280                 285             


Gly Thr Pro Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala 
    290                 295                 300                 


Lys Tyr Gly Ala Ala Ala Gly Leu Val Pro Gly Gly Pro Gly Phe Gly 
305                 310                 315                 320 


Pro Gly Val Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val 
                325                 330                 335     


Pro Gly Ala Gly Ile Pro Val Val Pro Gly Ala Gly Ile Pro Gly Ala 
            340                 345                 350         


Ala Val Pro Gly Val Val Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala 
        355                 360                 365             


Lys Ala Ala Lys Tyr Gly Ala Arg Pro Gly Val Gly Val Gly Gly Ile 
    370                 375                 380                 


Pro Thr Tyr Gly Val Gly Ala Gly Gly Phe Pro Gly Phe Gly Val Gly 
385                 390                 395                 400 


Val Gly Gly Ile Pro Gly Val Ala Gly Val Pro Gly Val Gly Gly Val 
                405                 410                 415     


Pro Gly Val Gly Gly Val Pro Gly Val Gly Ile Ser Pro Glu Ala Gln 
            420                 425                 430         


Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Leu Val Pro Gly Val 
        435                 440                 445             


Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro 
    450                 455                 460                 


Gly Val Gly Leu Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val 
465                 470                 475                 480 


Ala Pro Gly Val Gly Val Ala Pro Gly Ile Gly Pro Gly Gly Val Ala 
                485                 490                 495     


Ala Ala Ala Lys Ser Ala Ala Lys Val Ala Ala Lys Ala Gln Leu Arg 
            500                 505                 510         


Ala Ala Ala Gly Leu Gly Ala Gly Ile Pro Gly Leu Gly Val Gly Val 
        515                 520                 525             


Gly Val Pro Gly Leu Gly Val Gly Ala Gly Val Pro Gly Leu Gly Val 
    530                 535                 540                 


Gly Ala Gly Val Pro Gly Phe Gly Ala Val Pro Gly Ala Leu Ala Ala 
545                 550                 555                 560 


Ala Lys Ala Ala Lys Tyr Gly Ala Ala Val Pro Gly Val Leu Gly Gly 
                565                 570                 575     


Leu Gly Ala Leu Gly Gly Val Gly Ile Pro Gly Gly Val Val Gly Ala 
            580                 585                 590         


Gly Pro Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala 
        595                 600                 605             


Gln Phe Gly Leu Val Gly Ala Ala Gly Leu Gly Gly Leu Gly Val Gly 
    610                 615                 620                 


Gly Leu Gly Val Pro Gly Val Gly Gly Leu Gly Gly Ile Pro Pro Ala 
625                 630                 635                 640 


Ala Ala Ala Lys Ala Ala Lys Tyr Gly Val Ala Ala Arg Pro Gly Phe 
                645                 650                 655     


Gly Leu Ser Pro Ile Phe Pro Gly Gly Ala Cys Leu Gly Lys Ala Cys 
            660                 665                 670         


Gly Arg Lys Arg Lys 
        675         


<210>  4676
<211>  714
<212>  PRT
<213>  Homo Sapiens

<400>  4676

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30          


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Ala Leu Gly Pro 
        35                  40                  45              


Gly Gly Lys Pro Leu Lys Pro Val Pro Gly Gly Leu Ala Gly Ala Gly 
    50                  55                  60                  


Leu Gly Ala Gly Leu Gly Ala Phe Pro Ala Val Thr Phe Pro Gly Ala 
65                  70                  75                  80  


Leu Val Pro Gly Gly Val Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala 
                85                  90                  95      


Lys Ala Gly Ala Gly Leu Gly Gly Val Pro Gly Val Gly Gly Leu Gly 
            100                 105                 110         


Val Ser Ala Gly Ala Val Val Pro Gln Pro Gly Ala Gly Val Lys Pro 
        115                 120                 125             


Gly Lys Val Pro Gly Val Gly Leu Pro Gly Val Tyr Pro Gly Gly Val 
    130                 135                 140                 


Leu Pro Gly Ala Arg Phe Pro Gly Val Gly Val Leu Pro Gly Val Pro 
145                 150                 155                 160 


Thr Gly Ala Gly Val Lys Pro Lys Ala Pro Gly Val Gly Gly Ala Phe 
                165                 170                 175     


Ala Gly Ile Pro Gly Val Gly Pro Phe Gly Gly Pro Gln Pro Gly Val 
            180                 185                 190         


Pro Leu Gly Tyr Pro Ile Lys Ala Pro Lys Leu Pro Gly Gly Tyr Gly 
        195                 200                 205             


Leu Pro Tyr Thr Thr Gly Lys Leu Pro Tyr Gly Tyr Gly Pro Gly Gly 
    210                 215                 220                 


Val Ala Gly Ala Ala Gly Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val 
225                 230                 235                 240 


Gly Pro Gln Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Phe 
                245                 250                 255     


Gly Ala Gly Ala Ala Gly Val Leu Pro Gly Val Gly Gly Ala Gly Val 
            260                 265                 270         


Pro Gly Val Pro Gly Ala Ile Pro Gly Ile Gly Gly Ile Ala Gly Val 
        275                 280                 285             


Gly Thr Pro Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala 
    290                 295                 300                 


Lys Tyr Gly Ala Ala Ala Gly Leu Val Pro Gly Gly Pro Gly Phe Gly 
305                 310                 315                 320 


Pro Gly Val Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val 
                325                 330                 335     


Pro Gly Ala Gly Ile Pro Val Val Pro Gly Ala Gly Ile Pro Gly Ala 
            340                 345                 350         


Ala Val Pro Gly Val Val Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala 
        355                 360                 365             


Lys Ala Ala Lys Tyr Gly Ala Arg Pro Gly Val Gly Val Gly Gly Ile 
    370                 375                 380                 


Pro Thr Tyr Gly Val Gly Ala Gly Gly Phe Pro Gly Phe Gly Val Gly 
385                 390                 395                 400 


Val Gly Gly Ile Pro Gly Val Ala Gly Val Pro Gly Val Gly Gly Val 
                405                 410                 415     


Pro Gly Val Gly Gly Val Pro Gly Val Gly Ile Ser Pro Glu Ala Gln 
            420                 425                 430         


Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Val Gly Thr Pro Ala 
        435                 440                 445             


Ala Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Gln Phe Gly Leu Val 
    450                 455                 460                 


Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly 
465                 470                 475                 480 


Val Ala Pro Gly Val Gly Leu Ala Pro Gly Val Gly Val Ala Pro Gly 
                485                 490                 495     


Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Ile Gly Pro Gly 
            500                 505                 510         


Gly Val Ala Ala Ala Ala Lys Ser Ala Ala Lys Val Ala Ala Lys Ala 
        515                 520                 525             


Gln Leu Arg Ala Ala Ala Gly Leu Gly Ala Gly Ile Pro Gly Leu Gly 
    530                 535                 540                 


Val Gly Val Gly Val Pro Gly Leu Gly Val Gly Ala Gly Val Pro Gly 
545                 550                 555                 560 


Leu Gly Val Gly Ala Gly Val Pro Gly Phe Gly Ala Val Pro Gly Ala 
                565                 570                 575     


Leu Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Val Pro Gly Val 
            580                 585                 590         


Leu Gly Gly Leu Gly Ala Leu Gly Gly Val Gly Ile Pro Gly Gly Val 
        595                 600                 605             


Val Gly Ala Gly Pro Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala 
    610                 615                 620                 


Lys Ala Ala Gln Phe Gly Leu Val Gly Ala Ala Gly Leu Gly Gly Leu 
625                 630                 635                 640 


Gly Val Gly Gly Leu Gly Val Pro Gly Val Gly Gly Leu Gly Gly Ile 
                645                 650                 655     


Pro Pro Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Gly Leu 
            660                 665                 670         


Gly Gly Val Leu Gly Gly Ala Gly Gln Phe Pro Leu Gly Gly Val Ala 
        675                 680                 685             


Ala Arg Pro Gly Phe Gly Leu Ser Pro Ile Phe Pro Gly Gly Ala Cys 
    690                 695                 700                 


Leu Gly Lys Ala Cys Gly Arg Lys Arg Lys 
705                 710                 


<210>  4677
<211>  617
<212>  PRT
<213>  Homo Sapiens

<400>  4677

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30          


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Ala Leu Gly Pro 
        35                  40                  45              


Gly Gly Lys Pro Leu Lys Pro Val Pro Gly Gly Leu Ala Gly Ala Gly 
    50                  55                  60                  


Leu Gly Ala Gly Leu Gly Ala Phe Pro Ala Val Thr Phe Pro Gly Ala 
65                  70                  75                  80  


Leu Val Pro Gly Gly Val Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala 
                85                  90                  95      


Lys Ala Gly Ala Gly Leu Gly Gly Val Pro Gly Val Gly Gly Leu Gly 
            100                 105                 110         


Val Ser Ala Gly Ala Val Val Pro Gln Pro Gly Ala Gly Val Lys Pro 
        115                 120                 125             


Gly Lys Val Pro Gly Val Gly Leu Pro Gly Val Tyr Pro Gly Gly Val 
    130                 135                 140                 


Leu Pro Gly Val Gly Pro Phe Gly Gly Pro Gln Pro Gly Val Pro Leu 
145                 150                 155                 160 


Gly Tyr Pro Ile Lys Ala Pro Lys Leu Pro Gly Gly Tyr Gly Leu Pro 
                165                 170                 175     


Tyr Thr Thr Gly Lys Leu Pro Tyr Gly Tyr Gly Pro Gly Gly Val Ala 
            180                 185                 190         


Gly Ala Ala Gly Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val Gly Pro 
        195                 200                 205             


Gln Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Phe Gly Ala 
    210                 215                 220                 


Gly Ala Ala Gly Val Leu Pro Gly Val Gly Gly Ala Gly Val Pro Gly 
225                 230                 235                 240 


Val Pro Gly Ala Ile Pro Gly Ile Gly Gly Ile Ala Gly Val Gly Thr 
                245                 250                 255     


Pro Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr 
            260                 265                 270         


Gly Ala Ala Ala Gly Leu Val Pro Gly Gly Pro Gly Phe Gly Pro Gly 
        275                 280                 285             


Val Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly 
    290                 295                 300                 


Ala Gly Ile Pro Val Val Pro Gly Ala Gly Ile Pro Gly Ala Ala Val 
305                 310                 315                 320 


Pro Gly Val Val Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala Lys Ala 
                325                 330                 335     


Ala Lys Tyr Gly Ala Arg Pro Gly Val Gly Val Gly Gly Ile Pro Thr 
            340                 345                 350         


Tyr Gly Val Gly Ala Gly Gly Phe Pro Gly Phe Gly Val Gly Val Gly 
        355                 360                 365             


Ala Glu Ala Gln Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Leu 
    370                 375                 380                 


Val Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val 
385                 390                 395                 400 


Gly Val Ala Pro Gly Val Gly Leu Ala Pro Gly Val Gly Val Ala Pro 
                405                 410                 415     


Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Ile Gly Pro 
            420                 425                 430         


Gly Gly Val Ala Ala Ala Ala Lys Ser Ala Ala Lys Val Ala Ala Lys 
        435                 440                 445             


Ala Gln Leu Arg Ala Ala Ala Gly Leu Gly Ala Gly Ile Pro Gly Leu 
    450                 455                 460                 


Gly Val Gly Val Gly Val Pro Gly Leu Gly Val Gly Ala Gly Val Pro 
465                 470                 475                 480 


Gly Leu Gly Val Gly Ala Gly Val Pro Gly Phe Gly Ala Val Pro Gly 
                485                 490                 495     


Ala Leu Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Val Pro Gly 
            500                 505                 510         


Val Leu Gly Gly Leu Gly Ala Leu Gly Gly Val Gly Ile Pro Gly Gly 
        515                 520                 525             


Val Val Gly Ala Gly Pro Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala 
    530                 535                 540                 


Ala Lys Ala Ala Gln Phe Gly Leu Val Gly Ala Ala Gly Leu Gly Gly 
545                 550                 555                 560 


Leu Gly Val Gly Gly Leu Gly Val Pro Gly Val Gly Gly Leu Gly Gly 
                565                 570                 575     


Ile Pro Pro Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Val Ala Ala 
            580                 585                 590         


Arg Pro Gly Phe Gly Leu Ser Pro Ile Phe Pro Gly Gly Ala Cys Leu 
        595                 600                 605             


Gly Lys Ala Cys Gly Arg Lys Arg Lys 
    610                 615         


<210>  4678
<211>  294
<212>  PRT
<213>  Homo Sapiens

<400>  4678

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30          


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45              


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60                  


Pro Gly Leu Gly Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val 
65                  70                  75                  80  


Pro Gly Gly Val Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala 
                85                  90                  95      


Gly Ala Gly Leu Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser 
            100                 105                 110         


Ala Gly Ala Val Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly Lys 
        115                 120                 125             


Val Pro Gly Val Gly Leu Pro Gly Val Tyr Pro Gly Gly Val Leu Pro 
    130                 135                 140                 


Gly Ala Arg Phe Pro Gly Val Gly Val Leu Pro Gly Val Pro Thr Gly 
145                 150                 155                 160 


Ala Gly Val Lys Pro Lys Ala Pro Gly Val Gly Pro Phe Gly Gly Pro 
                165                 170                 175     


Gln Pro Gly Val Pro Leu Gly Tyr Pro Ile Lys Ala Pro Lys Leu Pro 
            180                 185                 190         


Gly Gly Tyr Gly Leu Pro Tyr Thr Thr Gly Lys Leu Pro Tyr Gly Tyr 
        195                 200                 205             


Gly Pro Gly Gly Val Ala Gly Ala Ala Gly Lys Ala Gly Tyr Pro Thr 
    210                 215                 220                 


Gly Thr Gly Val Gly Pro Gln Ala Ala Ala Ala Ala Ala Ala Lys Ala 
225                 230                 235                 240 


Ala Ala Lys Phe Gly Ala Gly Ala Ala Gly Val Leu Pro Gly Val Gly 
                245                 250                 255     


Gly Ala Gly Val Pro Gly Val Pro Gly Ala Ile Pro Gly Ile Gly Gly 
            260                 265                 270         


Ile Ala Gly Val Gly Thr Pro Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        275                 280                 285             


Ala Lys Ala Ala Lys Tyr 
    290                 


<210>  4679
<211>  643
<212>  PRT
<213>  Homo Sapiens

<400>  4679

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30          


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45              


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60                  


Pro Gly Leu Gly Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val 
65                  70                  75                  80  


Pro Gly Gly Val Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala 
                85                  90                  95      


Gly Ala Gly Leu Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser 
            100                 105                 110         


Ala Gly Ala Val Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly Lys 
        115                 120                 125             


Val Pro Gly Val Gly Leu Pro Gly Val Tyr Pro Gly Gly Val Leu Pro 
    130                 135                 140                 


Gly Ala Arg Phe Pro Gly Val Gly Val Leu Pro Gly Val Pro Thr Gly 
145                 150                 155                 160 


Ala Gly Val Lys Pro Lys Ala Pro Gly Val Gly Pro Phe Gly Gly Pro 
                165                 170                 175     


Gln Pro Gly Val Pro Leu Gly Tyr Pro Ile Lys Ala Pro Lys Leu Pro 
            180                 185                 190         


Gly Tyr Gly Pro Gly Gly Val Ala Gly Ala Ala Gly Lys Ala Gly Tyr 
        195                 200                 205             


Pro Thr Gly Thr Gly Val Gly Pro Gln Ala Ala Ala Ala Ala Ala Ala 
    210                 215                 220                 


Lys Ala Ala Ala Lys Phe Gly Ala Gly Ala Ala Gly Val Leu Pro Gly 
225                 230                 235                 240 


Val Gly Gly Ala Gly Val Pro Gly Val Pro Gly Ala Ile Pro Gly Ile 
                245                 250                 255     


Gly Gly Ile Ala Gly Val Gly Thr Pro Ala Ala Ala Ala Ala Ala Ala 
            260                 265                 270         


Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Ala Gly Leu Val Pro 
        275                 280                 285             


Gly Gly Pro Gly Phe Gly Pro Gly Val Val Gly Val Pro Gly Ala Gly 
    290                 295                 300                 


Val Pro Gly Val Gly Val Pro Gly Ala Gly Ile Pro Val Val Pro Gly 
305                 310                 315                 320 


Ala Gly Ile Pro Gly Ala Ala Val Pro Gly Val Val Ser Pro Glu Ala 
                325                 330                 335     


Ala Ala Lys Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Arg Pro Gly 
            340                 345                 350         


Val Gly Val Gly Gly Ile Pro Thr Tyr Gly Val Gly Ala Gly Gly Phe 
        355                 360                 365             


Pro Gly Phe Gly Val Gly Val Gly Ala Glu Ala Gln Ala Ala Ala Ala 
    370                 375                 380                 


Ala Lys Ala Ala Lys Tyr Gly Leu Val Pro Gly Val Gly Val Ala Pro 
385                 390                 395                 400 


Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Leu 
                405                 410                 415     


Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val 
            420                 425                 430         


Gly Val Ala Pro Gly Ile Gly Pro Gly Gly Val Ala Ala Ala Ala Lys 
        435                 440                 445             


Ser Ala Ala Lys Val Ala Ala Lys Ala Gln Leu Arg Ala Ala Ala Gly 
    450                 455                 460                 


Leu Gly Ala Gly Ile Pro Gly Leu Gly Val Gly Val Gly Val Pro Gly 
465                 470                 475                 480 


Leu Gly Val Gly Ala Gly Val Pro Gly Leu Gly Val Gly Ala Gly Val 
                485                 490                 495     


Pro Gly Phe Gly Ala Val Pro Gly Ala Leu Ala Ala Ala Lys Ala Ala 
            500                 505                 510         


Lys Tyr Gly Ala Ala Val Pro Gly Val Leu Gly Gly Leu Gly Ala Leu 
        515                 520                 525             


Gly Gly Val Gly Ile Pro Gly Gly Val Val Gly Ala Gly Pro Ala Ala 
    530                 535                 540                 


Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Gln Phe Gly Leu 
545                 550                 555                 560 


Val Gly Ala Ala Gly Leu Gly Gly Leu Gly Val Gly Gly Leu Gly Val 
                565                 570                 575     


Pro Gly Val Gly Gly Leu Gly Gly Ile Pro Pro Ala Ala Ala Ala Lys 
            580                 585                 590         


Ala Ala Lys Tyr Gly Ala Ala Gly Leu Gly Gly Val Leu Gly Gly Ala 
        595                 600                 605             


Gly Gln Phe Pro Leu Gly Gly Val Ala Ala Arg Pro Gly Phe Gly Leu 
    610                 615                 620                 


Ser Pro Ile Phe Pro Gly Gly Ala Cys Leu Gly Lys Ala Cys Gly Arg 
625                 630                 635                 640 


Lys Arg Lys 
            


<210>  4680
<211>  168
<212>  PRT
<213>  Homo Sapiens

<400>  4680

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30          


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45              


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60                  


Pro Gly Val Gly Pro Phe Gly Gly Pro Gln Pro Gly Val Pro Leu Gly 
65                  70                  75                  80  


Tyr Pro Ile Lys Ala Pro Lys Leu Pro Gly Tyr Gly Pro Gly Gly Val 
                85                  90                  95      


Ala Gly Ala Ala Gly Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val Gly 
            100                 105                 110         


Pro Gln Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Phe Gly 
        115                 120                 125             


Ala Gly Ala Ala Gly Val Leu Pro Gly Val Gly Gly Ala Gly Val Pro 
    130                 135                 140                 


Gly Val Pro Gly Ala Ile Pro Gly Ile Gly Gly Ile Ala Gly Val Gly 
145                 150                 155                 160 


Thr Pro Ala Ala Ala Ala Ala Ala 
                165             


<210>  4681
<211>  711
<212>  PRT
<213>  Homo Sapiens

<400>  4681

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30          


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45              


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60                  


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly 
65                  70                  75                  80  


Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Val 
                85                  90                  95      


Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala Gly Ala Gly Leu 
            100                 105                 110         


Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser Ala Ala Pro Ser 
        115                 120                 125             


Val Pro Gly Ala Val Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly 
    130                 135                 140                 


Lys Val Pro Gly Val Gly Leu Pro Gly Val Tyr Pro Gly Gly Val Leu 
145                 150                 155                 160 


Pro Gly Ala Arg Phe Pro Gly Val Gly Val Leu Pro Gly Val Pro Thr 
                165                 170                 175     


Gly Ala Gly Val Lys Pro Lys Ala Pro Gly Val Gly Gly Ala Phe Ala 
            180                 185                 190         


Gly Ile Pro Gly Val Gly Pro Phe Gly Gly Pro Gln Pro Gly Val Pro 
        195                 200                 205             


Leu Gly Tyr Pro Ile Lys Ala Pro Lys Leu Pro Gly Gly Tyr Gly Leu 
    210                 215                 220                 


Pro Tyr Thr Thr Gly Lys Leu Pro Tyr Gly Tyr Gly Pro Gly Gly Val 
225                 230                 235                 240 


Ala Gly Ala Ala Gly Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val Gly 
                245                 250                 255     


Pro Gln Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Phe Gly 
            260                 265                 270         


Ala Gly Ala Ala Gly Val Leu Pro Gly Val Gly Gly Ala Gly Val Pro 
        275                 280                 285             


Gly Val Pro Gly Ala Ile Pro Gly Ile Gly Gly Ile Ala Gly Val Gly 
    290                 295                 300                 


Thr Pro Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Lys 
305                 310                 315                 320 


Tyr Gly Ala Ala Ala Gly Leu Val Pro Gly Gly Pro Gly Phe Gly Pro 
                325                 330                 335     


Gly Val Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
            340                 345                 350         


Gly Ala Gly Ile Pro Val Val Pro Gly Ala Gly Ile Pro Gly Ala Ala 
        355                 360                 365             


Val Pro Gly Val Val Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala Lys 
    370                 375                 380                 


Ala Ala Lys Tyr Gly Ala Arg Pro Gly Val Gly Val Gly Gly Ile Pro 
385                 390                 395                 400 


Thr Tyr Gly Val Gly Ala Gly Gly Phe Pro Gly Phe Gly Val Gly Val 
                405                 410                 415     


Gly Gly Ile Pro Gly Val Ala Gly Val Pro Gly Val Gly Gly Val Pro 
            420                 425                 430         


Gly Val Gly Gly Val Pro Gly Val Gly Ile Ser Pro Glu Ala Gln Ala 
        435                 440                 445             


Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Val Gly Thr Pro Ala Ala 
    450                 455                 460                 


Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Gln Phe Gly Leu Val Pro 
465                 470                 475                 480 


Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val 
                485                 490                 495     


Ala Pro Gly Val Gly Leu Ala Pro Gly Val Gly Val Ala Pro Gly Val 
            500                 505                 510         


Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Ile Gly Pro Gly Gly 
        515                 520                 525             


Val Ala Ala Ala Ala Lys Ser Ala Ala Lys Val Ala Ala Lys Ala Gln 
    530                 535                 540                 


Leu Arg Ala Ala Ala Gly Leu Gly Ala Gly Ile Pro Gly Leu Gly Val 
545                 550                 555                 560 


Gly Val Gly Val Pro Gly Leu Gly Val Gly Ala Gly Val Pro Gly Leu 
                565                 570                 575     


Gly Val Gly Ala Gly Val Pro Gly Phe Gly Ala Val Pro Gly Ala Leu 
            580                 585                 590         


Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Val Pro Gly Val Leu 
        595                 600                 605             


Gly Gly Leu Gly Ala Leu Gly Gly Val Gly Ile Pro Gly Gly Val Val 
    610                 615                 620                 


Gly Ala Gly Pro Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys 
625                 630                 635                 640 


Ala Ala Gln Phe Gly Leu Val Gly Ala Ala Gly Leu Gly Gly Leu Gly 
                645                 650                 655     


Val Gly Gly Leu Gly Val Pro Gly Val Gly Gly Leu Gly Gly Ile Pro 
            660                 665                 670         


Pro Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Val Ala Ala Arg Pro 
        675                 680                 685             


Gly Phe Gly Leu Ser Pro Ile Phe Pro Gly Gly Ala Cys Leu Gly Lys 
    690                 695                 700                 


Ala Cys Gly Arg Lys Arg Lys 
705                 710     


<210>  4682
<211>  692
<212>  PRT
<213>  Homo Sapiens

<400>  4682

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30          


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45              


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60                  


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly 
65                  70                  75                  80  


Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Val 
                85                  90                  95      


Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala Gly Ala Gly Leu 
            100                 105                 110         


Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser Ala Ala Pro Ser 
        115                 120                 125             


Val Pro Gly Ala Val Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly 
    130                 135                 140                 


Lys Val Pro Gly Val Gly Leu Pro Gly Val Tyr Pro Gly Gly Val Leu 
145                 150                 155                 160 


Pro Gly Ala Arg Phe Pro Gly Val Gly Val Leu Pro Gly Val Pro Thr 
                165                 170                 175     


Gly Ala Gly Val Lys Pro Lys Ala Pro Gly Val Gly Gly Ala Phe Ala 
            180                 185                 190         


Gly Ile Pro Gly Val Gly Pro Phe Gly Gly Pro Gln Pro Gly Val Pro 
        195                 200                 205             


Leu Gly Tyr Pro Ile Lys Ala Pro Lys Leu Pro Gly Gly Tyr Gly Leu 
    210                 215                 220                 


Pro Tyr Thr Thr Gly Lys Leu Pro Tyr Gly Tyr Gly Pro Gly Gly Val 
225                 230                 235                 240 


Ala Gly Ala Ala Gly Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val Gly 
                245                 250                 255     


Pro Gln Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Phe Gly 
            260                 265                 270         


Ala Gly Ala Ala Gly Val Leu Pro Gly Val Gly Gly Ala Gly Val Pro 
        275                 280                 285             


Gly Val Pro Gly Ala Ile Pro Gly Ile Gly Gly Ile Ala Gly Val Gly 
    290                 295                 300                 


Thr Pro Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Lys 
305                 310                 315                 320 


Tyr Gly Ala Ala Ala Gly Leu Val Pro Gly Gly Pro Gly Phe Gly Pro 
                325                 330                 335     


Gly Val Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 
            340                 345                 350         


Gly Ala Gly Ile Pro Val Val Pro Gly Ala Gly Ile Pro Gly Ala Ala 
        355                 360                 365             


Val Pro Gly Val Val Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala Lys 
    370                 375                 380                 


Ala Ala Lys Tyr Gly Ala Arg Pro Gly Val Gly Val Gly Gly Ile Pro 
385                 390                 395                 400 


Thr Tyr Gly Val Gly Ala Gly Gly Phe Pro Gly Phe Gly Val Gly Val 
                405                 410                 415     


Gly Gly Ile Pro Gly Val Ala Gly Val Pro Gly Val Gly Gly Val Pro 
            420                 425                 430         


Gly Val Gly Gly Val Pro Gly Val Gly Ile Ser Pro Glu Ala Gln Ala 
        435                 440                 445             


Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Leu Val Pro Gly Val Gly 
    450                 455                 460                 


Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly 
465                 470                 475                 480 


Val Gly Leu Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala 
                485                 490                 495     


Pro Gly Val Gly Val Ala Pro Gly Ile Gly Pro Gly Gly Val Ala Ala 
            500                 505                 510         


Ala Ala Lys Ser Ala Ala Lys Val Ala Ala Lys Ala Gln Leu Arg Ala 
        515                 520                 525             


Ala Ala Gly Leu Gly Ala Gly Ile Pro Gly Leu Gly Val Gly Val Gly 
    530                 535                 540                 


Val Pro Gly Leu Gly Val Gly Ala Gly Val Pro Gly Leu Gly Val Gly 
545                 550                 555                 560 


Ala Gly Val Pro Gly Phe Gly Ala Val Pro Gly Ala Leu Ala Ala Ala 
                565                 570                 575     


Lys Ala Ala Lys Tyr Gly Ala Ala Val Pro Gly Val Leu Gly Gly Leu 
            580                 585                 590         


Gly Ala Leu Gly Gly Val Gly Ile Pro Gly Gly Val Val Gly Ala Gly 
        595                 600                 605             


Pro Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Gln 
    610                 615                 620                 


Phe Gly Leu Val Gly Ala Ala Gly Leu Gly Gly Leu Gly Val Gly Gly 
625                 630                 635                 640 


Leu Gly Val Pro Gly Val Gly Gly Leu Gly Gly Ile Pro Pro Ala Ala 
                645                 650                 655     


Ala Ala Lys Ala Ala Lys Tyr Gly Val Ala Ala Arg Pro Gly Phe Gly 
            660                 665                 670         


Leu Ser Pro Ile Phe Pro Gly Gly Ala Cys Leu Gly Lys Ala Cys Gly 
        675                 680                 685             


Arg Lys Arg Lys 
    690         


<210>  4683
<211>  176
<212>  PRT
<213>  Homo Sapiens

<400>  4683

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30          


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45              


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60                  


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly 
65                  70                  75                  80  


Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Val 
                85                  90                  95      


Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala Gly Ala Gly Leu 
            100                 105                 110         


Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser Ala Gly Ala Val 
        115                 120                 125             


Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly Lys Val Pro Gly Val 
    130                 135                 140                 


Gly Gly Ala Phe Ala Gly Ile Pro Gly Val Gly Pro Phe Gly Gly Pro 
145                 150                 155                 160 


Gln Pro Gly Val Pro Leu Gly Tyr Pro Ile Lys Ala Pro Lys Leu Pro 
                165                 170                 175     


<210>  4684
<211>  724
<212>  PRT
<213>  Homo Sapiens

<400>  4684

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30          


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45              


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60                  


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly 
65                  70                  75                  80  


Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Val 
                85                  90                  95      


Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala Gly Ala Gly Leu 
            100                 105                 110         


Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser Ala Gly Ala Val 
        115                 120                 125             


Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly Lys Val Pro Gly Val 
    130                 135                 140                 


Gly Leu Pro Gly Val Tyr Pro Gly Gly Val Leu Pro Gly Ala Arg Phe 
145                 150                 155                 160 


Pro Gly Val Gly Val Leu Pro Gly Val Pro Thr Gly Ala Gly Val Lys 
                165                 170                 175     


Pro Lys Ala Pro Gly Val Gly Gly Ala Phe Ala Gly Ile Pro Gly Val 
            180                 185                 190         


Gly Pro Phe Gly Gly Pro Gln Pro Gly Val Pro Leu Gly Tyr Pro Ile 
        195                 200                 205             


Lys Ala Pro Lys Leu Pro Gly Gly Tyr Gly Leu Pro Tyr Thr Thr Gly 
    210                 215                 220                 


Lys Leu Pro Tyr Gly Tyr Gly Pro Gly Gly Val Ala Gly Ala Ala Gly 
225                 230                 235                 240 


Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val Gly Pro Gln Ala Ala Ala 
                245                 250                 255     


Ala Ala Ala Ala Lys Ala Ala Ala Lys Phe Gly Ala Gly Ala Ala Gly 
            260                 265                 270         


Val Leu Pro Gly Val Gly Gly Ala Gly Val Pro Gly Val Pro Gly Ala 
        275                 280                 285             


Ile Pro Gly Ile Gly Gly Ile Ala Gly Val Gly Thr Pro Ala Ala Ala 
    290                 295                 300                 


Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Ala 
305                 310                 315                 320 


Gly Leu Val Pro Gly Gly Pro Gly Phe Gly Pro Gly Val Val Gly Val 
                325                 330                 335     


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Ile Pro 
            340                 345                 350         


Val Val Pro Gly Ala Gly Ile Pro Gly Ala Ala Val Pro Gly Val Val 
        355                 360                 365             


Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Lys Tyr Gly 
    370                 375                 380                 


Ala Arg Pro Gly Val Gly Val Gly Gly Ile Pro Thr Tyr Gly Val Gly 
385                 390                 395                 400 


Ala Gly Gly Phe Pro Gly Phe Gly Val Gly Val Gly Gly Ile Pro Gly 
                405                 410                 415     


Val Ala Gly Val Pro Gly Val Gly Gly Val Pro Gly Val Gly Gly Val 
            420                 425                 430         


Pro Gly Val Gly Ile Ser Pro Glu Ala Gln Ala Ala Ala Ala Ala Lys 
        435                 440                 445             


Ala Ala Lys Tyr Gly Val Gly Thr Pro Ala Ala Ala Ala Ala Lys Ala 
    450                 455                 460                 


Ala Ala Lys Ala Ala Gln Phe Gly Leu Val Pro Gly Val Gly Val Ala 
465                 470                 475                 480 


Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly 
                485                 490                 495     


Leu Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly 
            500                 505                 510         


Val Gly Val Ala Pro Gly Ile Gly Pro Gly Gly Val Ala Ala Ala Ala 
        515                 520                 525             


Lys Ser Ala Ala Lys Val Ala Ala Lys Ala Gln Leu Arg Ala Ala Ala 
    530                 535                 540                 


Gly Leu Gly Ala Gly Ile Pro Gly Leu Gly Val Gly Val Gly Val Pro 
545                 550                 555                 560 


Gly Leu Gly Val Gly Ala Gly Val Pro Gly Leu Gly Val Gly Ala Gly 
                565                 570                 575     


Val Pro Gly Phe Gly Ala Val Pro Gly Ala Leu Ala Ala Ala Lys Ala 
            580                 585                 590         


Ala Lys Tyr Gly Ala Ala Val Pro Gly Val Leu Gly Gly Leu Gly Ala 
        595                 600                 605             


Leu Gly Gly Val Gly Ile Pro Gly Gly Val Val Gly Ala Gly Pro Ala 
    610                 615                 620                 


Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Gln Phe Gly 
625                 630                 635                 640 


Leu Val Gly Ala Ala Gly Leu Gly Gly Leu Gly Val Gly Gly Leu Gly 
                645                 650                 655     


Val Pro Gly Val Gly Gly Leu Gly Gly Ile Pro Pro Ala Ala Ala Ala 
            660                 665                 670         


Lys Ala Ala Lys Tyr Gly Ala Ala Gly Leu Gly Gly Val Leu Gly Gly 
        675                 680                 685             


Ala Gly Gln Phe Pro Leu Gly Gly Val Ala Ala Arg Pro Gly Phe Gly 
    690                 695                 700                 


Leu Ser Pro Ile Phe Pro Gly Gly Ala Cys Leu Gly Lys Ala Cys Gly 
705                 710                 715                 720 


Arg Lys Arg Lys 
                


<210>  4685
<211>  757
<212>  PRT
<213>  Homo Sapiens

<400>  4685

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30          


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45              


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60                  


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly 
65                  70                  75                  80  


Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Val 
                85                  90                  95      


Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala Gly Ala Gly Leu 
            100                 105                 110         


Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser Ala Gly Ala Val 
        115                 120                 125             


Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly Lys Val Pro Gly Val 
    130                 135                 140                 


Gly Leu Pro Gly Val Tyr Pro Gly Gly Val Leu Pro Gly Ala Arg Phe 
145                 150                 155                 160 


Pro Gly Val Gly Val Leu Pro Gly Val Pro Thr Gly Ala Gly Val Lys 
                165                 170                 175     


Pro Lys Ala Pro Gly Val Gly Gly Ala Phe Ala Gly Ile Pro Gly Val 
            180                 185                 190         


Gly Pro Phe Gly Gly Pro Gln Pro Gly Val Pro Leu Gly Tyr Pro Ile 
        195                 200                 205             


Lys Ala Pro Lys Leu Pro Gly Gly Tyr Gly Leu Pro Tyr Thr Thr Gly 
    210                 215                 220                 


Lys Leu Pro Tyr Gly Tyr Gly Pro Gly Gly Val Ala Gly Ala Ala Gly 
225                 230                 235                 240 


Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val Gly Pro Gln Ala Ala Ala 
                245                 250                 255     


Ala Ala Ala Ala Lys Ala Ala Ala Lys Phe Gly Ala Gly Ala Ala Gly 
            260                 265                 270         


Val Leu Pro Gly Val Gly Gly Ala Gly Val Pro Gly Val Pro Gly Ala 
        275                 280                 285             


Ile Pro Gly Ile Gly Gly Ile Ala Gly Val Gly Thr Pro Ala Ala Ala 
    290                 295                 300                 


Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Ala 
305                 310                 315                 320 


Gly Leu Val Pro Gly Gly Pro Gly Phe Gly Pro Gly Val Val Gly Val 
                325                 330                 335     


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Ile Pro 
            340                 345                 350         


Val Val Pro Gly Ala Gly Ile Pro Gly Ala Ala Val Pro Gly Val Val 
        355                 360                 365             


Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Lys Tyr Gly 
    370                 375                 380                 


Ala Arg Pro Gly Val Gly Val Gly Gly Ile Pro Thr Tyr Gly Val Gly 
385                 390                 395                 400 


Ala Gly Gly Phe Pro Gly Phe Gly Val Gly Val Gly Gly Ile Pro Gly 
                405                 410                 415     


Val Ala Gly Val Pro Gly Val Gly Gly Val Pro Gly Val Gly Gly Val 
            420                 425                 430         


Pro Gly Val Gly Ile Ser Pro Glu Ala Gln Ala Ala Ala Ala Ala Lys 
        435                 440                 445             


Ala Ala Lys Tyr Gly Val Gly Thr Pro Ala Ala Ala Ala Ala Lys Ala 
    450                 455                 460                 


Ala Ala Lys Ala Ala Gln Phe Gly Leu Val Pro Gly Val Gly Val Ala 
465                 470                 475                 480 


Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly 
                485                 490                 495     


Leu Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly 
            500                 505                 510         


Val Gly Val Ala Pro Gly Ile Gly Pro Gly Gly Val Ala Ala Ala Ala 
        515                 520                 525             


Lys Ser Ala Ala Lys Val Ala Ala Lys Ala Gln Leu Arg Ala Ala Ala 
    530                 535                 540                 


Gly Leu Gly Ala Gly Ile Pro Gly Leu Gly Val Gly Val Gly Val Pro 
545                 550                 555                 560 


Gly Leu Gly Val Gly Ala Gly Val Pro Gly Leu Gly Val Gly Ala Gly 
                565                 570                 575     


Val Pro Gly Phe Gly Ala Gly Ala Asp Glu Gly Val Arg Arg Ser Leu 
            580                 585                 590         


Ser Pro Glu Leu Arg Glu Gly Asp Pro Ser Ser Ser Gln His Leu Pro 
        595                 600                 605             


Ser Thr Pro Ser Ser Pro Arg Val Pro Gly Ala Leu Ala Ala Ala Lys 
    610                 615                 620                 


Ala Ala Lys Tyr Gly Ala Ala Val Pro Gly Val Leu Gly Gly Leu Gly 
625                 630                 635                 640 


Ala Leu Gly Gly Val Gly Ile Pro Gly Gly Val Val Gly Ala Gly Pro 
                645                 650                 655     


Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Gln Phe 
            660                 665                 670         


Gly Leu Val Gly Ala Ala Gly Leu Gly Gly Leu Gly Val Gly Gly Leu 
        675                 680                 685             


Gly Val Pro Gly Val Gly Gly Leu Gly Gly Ile Pro Pro Ala Ala Ala 
    690                 695                 700                 


Ala Lys Ala Ala Lys Tyr Gly Ala Ala Gly Leu Gly Gly Val Leu Gly 
705                 710                 715                 720 


Gly Ala Gly Gln Phe Pro Leu Gly Gly Val Ala Ala Arg Pro Gly Phe 
                725                 730                 735     


Gly Leu Ser Pro Ile Phe Pro Gly Gly Ala Cys Leu Gly Lys Ala Cys 
            740                 745                 750         


Gly Arg Lys Arg Lys 
        755         


<210>  4686
<211>  786
<212>  PRT
<213>  Homo Sapiens

<400>  4686

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30          


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45              


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60                  


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly 
65                  70                  75                  80  


Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Val 
                85                  90                  95      


Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala Gly Ala Gly Leu 
            100                 105                 110         


Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser Ala Gly Ala Val 
        115                 120                 125             


Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly Lys Val Pro Gly Val 
    130                 135                 140                 


Gly Leu Pro Gly Val Tyr Pro Gly Gly Val Leu Pro Gly Ala Arg Phe 
145                 150                 155                 160 


Pro Gly Val Gly Val Leu Pro Gly Val Pro Thr Gly Ala Gly Val Lys 
                165                 170                 175     


Pro Lys Ala Pro Gly Val Gly Gly Ala Phe Ala Gly Ile Pro Gly Val 
            180                 185                 190         


Gly Pro Phe Gly Gly Pro Gln Pro Gly Val Pro Leu Gly Tyr Pro Ile 
        195                 200                 205             


Lys Ala Pro Lys Leu Pro Gly Gly Tyr Gly Leu Pro Tyr Thr Thr Gly 
    210                 215                 220                 


Lys Leu Pro Tyr Gly Tyr Gly Pro Gly Gly Val Ala Gly Ala Ala Gly 
225                 230                 235                 240 


Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val Gly Pro Gln Ala Ala Ala 
                245                 250                 255     


Ala Ala Ala Ala Lys Ala Ala Ala Lys Phe Gly Ala Gly Ala Ala Gly 
            260                 265                 270         


Val Leu Pro Gly Val Gly Gly Ala Gly Val Pro Gly Val Pro Gly Ala 
        275                 280                 285             


Ile Pro Gly Ile Gly Gly Ile Ala Gly Val Gly Thr Pro Ala Ala Ala 
    290                 295                 300                 


Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Ala 
305                 310                 315                 320 


Gly Leu Val Pro Gly Gly Pro Gly Phe Gly Pro Gly Val Val Gly Val 
                325                 330                 335     


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Ile Pro 
            340                 345                 350         


Val Val Pro Gly Ala Gly Ile Pro Gly Ala Ala Val Pro Gly Val Val 
        355                 360                 365             


Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Lys Tyr Gly 
    370                 375                 380                 


Ala Arg Pro Gly Val Gly Val Gly Gly Ile Pro Thr Tyr Gly Val Gly 
385                 390                 395                 400 


Ala Gly Gly Phe Pro Gly Phe Gly Val Gly Val Gly Gly Ile Pro Gly 
                405                 410                 415     


Val Ala Gly Val Pro Gly Val Gly Gly Val Pro Gly Val Gly Gly Val 
            420                 425                 430         


Pro Gly Val Gly Ile Ser Pro Glu Ala Gln Ala Ala Ala Ala Ala Lys 
        435                 440                 445             


Ala Ala Lys Tyr Gly Ala Ala Gly Ala Gly Val Leu Gly Gly Leu Val 
    450                 455                 460                 


Pro Gly Ala Pro Gly Ala Val Pro Gly Val Pro Gly Thr Gly Gly Val 
465                 470                 475                 480 


Pro Gly Val Gly Thr Pro Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys 
                485                 490                 495     


Ala Ala Gln Phe Gly Leu Val Pro Gly Val Gly Val Ala Pro Gly Val 
            500                 505                 510         


Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Leu Ala Pro 
        515                 520                 525             


Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val 
    530                 535                 540                 


Ala Pro Gly Ile Gly Pro Gly Gly Val Ala Ala Ala Ala Lys Ser Ala 
545                 550                 555                 560 


Ala Lys Val Ala Ala Lys Ala Gln Leu Arg Ala Ala Ala Gly Leu Gly 
                565                 570                 575     


Ala Gly Ile Pro Gly Leu Gly Val Gly Val Gly Val Pro Gly Leu Gly 
            580                 585                 590         


Val Gly Ala Gly Val Pro Gly Leu Gly Val Gly Ala Gly Val Pro Gly 
        595                 600                 605             


Phe Gly Ala Gly Ala Asp Glu Gly Val Arg Arg Ser Leu Ser Pro Glu 
    610                 615                 620                 


Leu Arg Glu Gly Asp Pro Ser Ser Ser Gln His Leu Pro Ser Thr Pro 
625                 630                 635                 640 


Ser Ser Pro Arg Val Pro Gly Ala Leu Ala Ala Ala Lys Ala Ala Lys 
                645                 650                 655     


Tyr Gly Ala Ala Val Pro Gly Val Leu Gly Gly Leu Gly Ala Leu Gly 
            660                 665                 670         


Gly Val Gly Ile Pro Gly Gly Val Val Gly Ala Gly Pro Ala Ala Ala 
        675                 680                 685             


Ala Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Gln Phe Gly Leu Val 
    690                 695                 700                 


Gly Ala Ala Gly Leu Gly Gly Leu Gly Val Gly Gly Leu Gly Val Pro 
705                 710                 715                 720 


Gly Val Gly Gly Leu Gly Gly Ile Pro Pro Ala Ala Ala Ala Lys Ala 
                725                 730                 735     


Ala Lys Tyr Gly Ala Ala Gly Leu Gly Gly Val Leu Gly Gly Ala Gly 
            740                 745                 750         


Gln Phe Pro Leu Gly Gly Val Ala Ala Arg Pro Gly Phe Gly Leu Ser 
        755                 760                 765             


Pro Ile Phe Pro Gly Gly Ala Cys Leu Gly Lys Ala Cys Gly Arg Lys 
    770                 775                 780                 


Arg Lys 
785     


<210>  4687
<211>  706
<212>  PRT
<213>  Homo Sapiens

<400>  4687

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30          


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45              


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60                  


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly 
65                  70                  75                  80  


Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Val 
                85                  90                  95      


Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala Gly Ala Gly Leu 
            100                 105                 110         


Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser Ala Gly Ala Val 
        115                 120                 125             


Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly Lys Val Pro Gly Val 
    130                 135                 140                 


Gly Leu Pro Gly Val Tyr Pro Gly Gly Val Leu Pro Gly Ala Arg Phe 
145                 150                 155                 160 


Pro Gly Val Gly Val Leu Pro Gly Val Pro Thr Gly Ala Gly Val Lys 
                165                 170                 175     


Pro Lys Ala Pro Gly Val Gly Gly Ala Phe Ala Gly Ile Pro Gly Val 
            180                 185                 190         


Gly Pro Phe Gly Gly Pro Gln Pro Gly Val Pro Leu Gly Tyr Pro Ile 
        195                 200                 205             


Lys Ala Pro Lys Leu Pro Gly Gly Tyr Gly Leu Pro Tyr Thr Thr Gly 
    210                 215                 220                 


Lys Leu Pro Tyr Gly Tyr Gly Pro Gly Gly Val Ala Gly Ala Ala Gly 
225                 230                 235                 240 


Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val Gly Pro Gln Ala Ala Ala 
                245                 250                 255     


Ala Ala Ala Ala Lys Ala Ala Ala Lys Phe Gly Ala Gly Ala Ala Gly 
            260                 265                 270         


Val Leu Pro Gly Val Gly Gly Ala Gly Val Pro Gly Val Pro Gly Ala 
        275                 280                 285             


Ile Pro Gly Ile Gly Gly Ile Ala Gly Val Gly Thr Pro Ala Ala Ala 
    290                 295                 300                 


Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Ala 
305                 310                 315                 320 


Gly Leu Val Pro Gly Gly Pro Gly Phe Gly Pro Gly Val Val Gly Val 
                325                 330                 335     


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Ile Pro 
            340                 345                 350         


Val Val Pro Gly Ala Gly Ile Pro Gly Ala Ala Val Pro Gly Val Val 
        355                 360                 365             


Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Lys Tyr Gly 
    370                 375                 380                 


Ala Arg Pro Gly Val Gly Val Gly Gly Ile Pro Thr Tyr Gly Val Gly 
385                 390                 395                 400 


Ala Gly Gly Phe Pro Gly Phe Gly Val Gly Val Gly Gly Ile Pro Gly 
                405                 410                 415     


Val Ala Gly Val Pro Gly Val Gly Gly Val Pro Gly Val Gly Gly Val 
            420                 425                 430         


Pro Gly Val Gly Ile Ser Pro Glu Ala Gln Ala Ala Ala Ala Ala Lys 
        435                 440                 445             


Ala Ala Lys Tyr Gly Val Gly Thr Pro Ala Ala Ala Ala Ala Lys Ala 
    450                 455                 460                 


Ala Ala Lys Ala Ala Gln Phe Gly Leu Val Pro Gly Val Gly Val Ala 
465                 470                 475                 480 


Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly 
                485                 490                 495     


Leu Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly 
            500                 505                 510         


Val Gly Val Ala Pro Gly Ile Gly Pro Gly Gly Val Ala Ala Ala Ala 
        515                 520                 525             


Lys Ser Ala Ala Lys Val Ala Ala Lys Ala Gln Leu Arg Ala Ala Ala 
    530                 535                 540                 


Gly Leu Gly Ala Gly Ile Pro Gly Leu Gly Val Gly Val Gly Val Pro 
545                 550                 555                 560 


Gly Leu Gly Val Gly Ala Gly Val Pro Gly Leu Gly Val Gly Ala Gly 
                565                 570                 575     


Val Pro Gly Phe Gly Ala Val Pro Gly Ala Leu Ala Ala Ala Lys Ala 
            580                 585                 590         


Ala Lys Tyr Gly Ala Ala Val Pro Gly Val Leu Gly Gly Leu Gly Ala 
        595                 600                 605             


Leu Gly Gly Val Gly Ile Pro Gly Gly Val Val Gly Ala Gly Pro Ala 
    610                 615                 620                 


Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Gln Phe Gly 
625                 630                 635                 640 


Leu Val Gly Ala Ala Gly Leu Gly Gly Leu Gly Val Gly Gly Leu Gly 
                645                 650                 655     


Val Pro Gly Val Gly Gly Leu Gly Gly Ile Pro Pro Ala Ala Ala Ala 
            660                 665                 670         


Lys Ala Ala Lys Tyr Gly Val Ala Ala Arg Pro Gly Phe Gly Leu Ser 
        675                 680                 685             


Pro Ile Phe Pro Gly Gly Ala Cys Leu Gly Lys Ala Cys Gly Arg Lys 
    690                 695                 700                 


Arg Lys 
705     


<210>  4688
<211>  730
<212>  PRT
<213>  Homo Sapiens

<400>  4688

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30          


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45              


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60                  


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly 
65                  70                  75                  80  


Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Val 
                85                  90                  95      


Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala Gly Ala Gly Leu 
            100                 105                 110         


Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser Ala Gly Ala Val 
        115                 120                 125             


Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly Lys Val Pro Gly Val 
    130                 135                 140                 


Gly Leu Pro Gly Val Tyr Pro Gly Gly Val Leu Pro Gly Ala Arg Phe 
145                 150                 155                 160 


Pro Gly Val Gly Val Leu Pro Gly Val Pro Thr Gly Ala Gly Val Lys 
                165                 170                 175     


Pro Lys Ala Pro Gly Val Gly Gly Ala Phe Ala Gly Ile Pro Gly Val 
            180                 185                 190         


Gly Pro Phe Gly Gly Pro Gln Pro Gly Val Pro Leu Gly Tyr Pro Ile 
        195                 200                 205             


Lys Ala Pro Lys Leu Pro Gly Gly Tyr Gly Leu Pro Tyr Thr Thr Gly 
    210                 215                 220                 


Lys Leu Pro Tyr Gly Tyr Gly Pro Gly Gly Val Ala Gly Ala Ala Gly 
225                 230                 235                 240 


Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val Gly Pro Gln Ala Ala Ala 
                245                 250                 255     


Ala Ala Ala Ala Lys Ala Ala Ala Lys Phe Gly Ala Gly Ala Ala Gly 
            260                 265                 270         


Val Leu Pro Gly Val Gly Gly Ala Gly Val Pro Gly Val Pro Gly Ala 
        275                 280                 285             


Ile Pro Gly Ile Gly Gly Ile Ala Gly Val Gly Thr Pro Ala Ala Ala 
    290                 295                 300                 


Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Ala 
305                 310                 315                 320 


Gly Leu Val Pro Gly Gly Pro Gly Phe Gly Pro Gly Val Val Gly Val 
                325                 330                 335     


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Ile Pro 
            340                 345                 350         


Val Val Pro Gly Ala Gly Ile Pro Gly Ala Ala Val Pro Gly Val Val 
        355                 360                 365             


Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Lys Tyr Gly 
    370                 375                 380                 


Ala Arg Pro Gly Val Gly Val Gly Gly Ile Pro Thr Tyr Gly Val Gly 
385                 390                 395                 400 


Ala Gly Gly Phe Pro Gly Phe Gly Val Gly Val Gly Gly Ile Pro Gly 
                405                 410                 415     


Val Ala Gly Val Pro Gly Val Gly Gly Val Pro Gly Val Gly Gly Val 
            420                 425                 430         


Pro Gly Val Gly Ile Ser Pro Glu Ala Gln Ala Ala Ala Ala Ala Lys 
        435                 440                 445             


Ala Ala Lys Tyr Gly Val Gly Thr Pro Ala Ala Ala Ala Ala Lys Ala 
    450                 455                 460                 


Ala Ala Lys Ala Ala Gln Phe Ala Leu Leu Asn Leu Ala Gly Leu Val 
465                 470                 475                 480 


Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly 
                485                 490                 495     


Val Ala Pro Gly Val Gly Leu Ala Pro Gly Val Gly Val Ala Pro Gly 
            500                 505                 510         


Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Ile Gly Pro Gly 
        515                 520                 525             


Gly Val Ala Ala Ala Ala Lys Ser Ala Ala Lys Val Ala Ala Lys Ala 
    530                 535                 540                 


Gln Leu Arg Ala Ala Ala Gly Leu Gly Ala Gly Ile Pro Gly Leu Gly 
545                 550                 555                 560 


Val Gly Val Gly Val Pro Gly Leu Gly Val Gly Ala Gly Val Pro Gly 
                565                 570                 575     


Leu Gly Val Gly Ala Gly Val Pro Gly Phe Gly Ala Val Pro Gly Ala 
            580                 585                 590         


Leu Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Val Pro Gly Val 
        595                 600                 605             


Leu Gly Gly Leu Gly Ala Leu Gly Gly Val Gly Ile Pro Gly Gly Val 
    610                 615                 620                 


Val Gly Ala Gly Pro Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala 
625                 630                 635                 640 


Lys Ala Ala Gln Phe Gly Leu Val Gly Ala Ala Gly Leu Gly Gly Leu 
                645                 650                 655     


Gly Val Gly Gly Leu Gly Val Pro Gly Val Gly Gly Leu Gly Gly Ile 
            660                 665                 670         


Pro Pro Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Gly Leu 
        675                 680                 685             


Gly Gly Val Leu Gly Gly Ala Gly Gln Phe Pro Leu Gly Gly Val Ala 
    690                 695                 700                 


Ala Arg Pro Gly Phe Gly Leu Ser Pro Ile Phe Pro Gly Gly Ala Cys 
705                 710                 715                 720 


Leu Gly Lys Ala Cys Gly Arg Lys Arg Lys 
                725                 730 


<210>  4689
<211>  705
<212>  PRT
<213>  Homo Sapiens

<400>  4689

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30          


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45              


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60                  


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly 
65                  70                  75                  80  


Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Val 
                85                  90                  95      


Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala Gly Ala Gly Leu 
            100                 105                 110         


Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser Ala Gly Ala Val 
        115                 120                 125             


Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly Lys Val Pro Gly Val 
    130                 135                 140                 


Gly Leu Pro Gly Val Tyr Pro Gly Gly Val Leu Pro Gly Ala Arg Phe 
145                 150                 155                 160 


Pro Gly Val Gly Val Leu Pro Gly Val Pro Thr Gly Ala Gly Val Lys 
                165                 170                 175     


Pro Lys Ala Pro Gly Val Gly Gly Ala Phe Ala Gly Ile Pro Gly Val 
            180                 185                 190         


Gly Pro Phe Gly Gly Pro Gln Pro Gly Val Pro Leu Gly Tyr Pro Ile 
        195                 200                 205             


Lys Ala Pro Lys Leu Pro Gly Gly Tyr Gly Leu Pro Tyr Thr Thr Gly 
    210                 215                 220                 


Lys Leu Pro Tyr Gly Tyr Gly Pro Gly Gly Val Ala Gly Ala Ala Gly 
225                 230                 235                 240 


Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val Gly Pro Gln Ala Ala Ala 
                245                 250                 255     


Ala Ala Ala Ala Lys Ala Ala Ala Lys Phe Gly Ala Gly Ala Ala Gly 
            260                 265                 270         


Val Leu Pro Gly Val Gly Gly Ala Gly Val Pro Gly Val Pro Gly Ala 
        275                 280                 285             


Ile Pro Gly Ile Gly Gly Ile Ala Gly Val Gly Thr Pro Ala Ala Ala 
    290                 295                 300                 


Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Ala 
305                 310                 315                 320 


Gly Leu Val Pro Gly Gly Pro Gly Phe Gly Pro Gly Val Val Gly Val 
                325                 330                 335     


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Ile Pro 
            340                 345                 350         


Val Val Pro Gly Ala Gly Ile Pro Gly Ala Ala Val Pro Gly Val Val 
        355                 360                 365             


Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Lys Tyr Gly 
    370                 375                 380                 


Ala Arg Pro Gly Val Gly Val Gly Gly Ile Pro Thr Tyr Gly Val Gly 
385                 390                 395                 400 


Ala Gly Gly Phe Pro Gly Phe Gly Val Gly Val Gly Gly Ile Pro Gly 
                405                 410                 415     


Val Ala Gly Val Pro Gly Val Gly Gly Val Pro Gly Val Gly Gly Val 
            420                 425                 430         


Pro Gly Val Gly Ile Ser Pro Glu Ala Gln Ala Ala Ala Ala Ala Lys 
        435                 440                 445             


Ala Ala Lys Tyr Gly Leu Val Pro Gly Val Gly Val Ala Pro Gly Val 
    450                 455                 460                 


Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Leu Ala Pro 
465                 470                 475                 480 


Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val 
                485                 490                 495     


Ala Pro Gly Ile Gly Pro Gly Gly Val Ala Ala Ala Ala Lys Ser Ala 
            500                 505                 510         


Ala Lys Val Ala Ala Lys Ala Gln Leu Arg Ala Ala Ala Gly Leu Gly 
        515                 520                 525             


Ala Gly Ile Pro Gly Leu Gly Val Gly Val Gly Val Pro Gly Leu Gly 
    530                 535                 540                 


Val Gly Ala Gly Val Pro Gly Leu Gly Val Gly Ala Gly Val Pro Gly 
545                 550                 555                 560 


Phe Gly Ala Val Pro Gly Ala Leu Ala Ala Ala Lys Ala Ala Lys Tyr 
                565                 570                 575     


Gly Ala Ala Val Pro Gly Val Leu Gly Gly Leu Gly Ala Leu Gly Gly 
            580                 585                 590         


Val Gly Ile Pro Gly Gly Val Val Gly Ala Gly Pro Ala Ala Ala Ala 
        595                 600                 605             


Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Gln Phe Gly Leu Val Gly 
    610                 615                 620                 


Ala Ala Gly Leu Gly Gly Leu Gly Val Gly Gly Leu Gly Val Pro Gly 
625                 630                 635                 640 


Val Gly Gly Leu Gly Gly Ile Pro Pro Ala Ala Ala Ala Lys Ala Ala 
                645                 650                 655     


Lys Tyr Gly Ala Ala Gly Leu Gly Gly Val Leu Gly Gly Ala Gly Gln 
            660                 665                 670         


Phe Pro Leu Gly Gly Val Ala Ala Arg Pro Gly Phe Gly Leu Ser Pro 
        675                 680                 685             


Ile Phe Pro Gly Gly Ala Cys Leu Gly Lys Ala Cys Gly Arg Lys Arg 
    690                 695                 700                 


Lys 
705 


<210>  4690
<211>  658
<212>  PRT
<213>  Homo Sapiens

<400>  4690

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30          


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45              


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60                  


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly 
65                  70                  75                  80  


Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Val 
                85                  90                  95      


Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala Gly Ala Gly Leu 
            100                 105                 110         


Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser Ala Gly Ala Val 
        115                 120                 125             


Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly Lys Val Pro Gly Val 
    130                 135                 140                 


Gly Leu Pro Gly Val Tyr Pro Gly Gly Val Leu Pro Gly Ala Arg Phe 
145                 150                 155                 160 


Pro Gly Val Gly Val Leu Pro Gly Val Pro Thr Gly Ala Gly Val Lys 
                165                 170                 175     


Pro Lys Ala Pro Gly Val Gly Gly Ala Phe Ala Gly Ile Pro Gly Val 
            180                 185                 190         


Gly Pro Phe Gly Gly Pro Gln Pro Gly Val Pro Leu Gly Tyr Pro Ile 
        195                 200                 205             


Lys Ala Pro Lys Leu Pro Gly Tyr Gly Pro Gly Gly Val Ala Gly Ala 
    210                 215                 220                 


Ala Gly Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val Gly Pro Gln Ala 
225                 230                 235                 240 


Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Phe Gly Ala Gly Ala 
                245                 250                 255     


Ala Gly Val Leu Pro Gly Val Gly Gly Ala Gly Val Pro Gly Val Pro 
            260                 265                 270         


Gly Ala Ile Pro Gly Ile Gly Gly Ile Ala Gly Val Gly Thr Pro Ala 
        275                 280                 285             


Ala Ala Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala 
    290                 295                 300                 


Ala Ala Gly Leu Val Pro Gly Gly Pro Gly Phe Gly Pro Gly Val Val 
305                 310                 315                 320 


Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly 
                325                 330                 335     


Ile Pro Val Val Pro Gly Ala Gly Ile Pro Gly Ala Ala Val Pro Gly 
            340                 345                 350         


Val Val Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Lys 
        355                 360                 365             


Tyr Gly Ala Arg Pro Gly Val Gly Val Gly Gly Ile Pro Thr Tyr Gly 
    370                 375                 380                 


Val Gly Ala Gly Gly Phe Pro Gly Phe Gly Val Gly Val Gly Gly Ile 
385                 390                 395                 400 


Pro Gly Val Ala Gly Val Pro Gly Val Gly Gly Val Pro Gly Val Gly 
                405                 410                 415     


Gly Val Pro Gly Val Gly Ile Ser Pro Glu Ala Gln Ala Ala Ala Ala 
            420                 425                 430         


Ala Lys Ala Ala Lys Tyr Gly Leu Val Pro Gly Val Gly Val Ala Pro 
        435                 440                 445             


Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Leu 
    450                 455                 460                 


Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val 
465                 470                 475                 480 


Gly Val Ala Pro Gly Ile Gly Pro Gly Gly Val Ala Gly Ala Ala Ala 
                485                 490                 495     


Gly Leu Gly Ala Gly Ile Pro Gly Leu Gly Val Gly Val Gly Val Pro 
            500                 505                 510         


Gly Leu Gly Val Gly Ala Gly Val Pro Gly Leu Gly Val Gly Ala Gly 
        515                 520                 525             


Val Pro Gly Phe Gly Ala Val Pro Gly Ala Leu Ala Ala Ala Lys Ala 
    530                 535                 540                 


Ala Lys Tyr Gly Ala Ala Val Pro Gly Val Leu Gly Gly Leu Gly Ala 
545                 550                 555                 560 


Leu Gly Gly Val Gly Ile Pro Gly Gly Val Val Gly Ala Gly Pro Ala 
                565                 570                 575     


Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Gln Phe Gly 
            580                 585                 590         


Leu Val Gly Ala Ala Gly Leu Gly Gly Leu Gly Val Gly Gly Leu Gly 
        595                 600                 605             


Val Pro Gly Val Gly Gly Leu Gly Gly Ile Pro Pro Ala Ala Ala Ala 
    610                 615                 620                 


Lys Ala Ala Lys Tyr Gly Val Ala Ala Arg Pro Gly Phe Gly Leu Ser 
625                 630                 635                 640 


Pro Ile Phe Pro Gly Gly Ala Cys Leu Gly Lys Ala Cys Gly Arg Lys 
                645                 650                 655     


Arg Lys 
        


<210>  4691
<211>  214
<212>  PRT
<213>  Homo Sapiens

<400>  4691

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30          


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45              


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60                  


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly 
65                  70                  75                  80  


Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Val 
                85                  90                  95      


Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala Gly Ala Gly Leu 
            100                 105                 110         


Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser Ala Gly Ala Val 
        115                 120                 125             


Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly Lys Val Pro Gly Val 
    130                 135                 140                 


Gly Leu Pro Gly Val Tyr Pro Gly Gly Val Leu Pro Gly Val Gly Pro 
145                 150                 155                 160 


Phe Gly Gly Pro Gln Pro Gly Val Pro Leu Gly Tyr Pro Ile Lys Ala 
                165                 170                 175     


Pro Lys Leu Pro Gly Gly Tyr Gly Leu Pro Tyr Thr Thr Gly Lys Leu 
            180                 185                 190         


Pro Tyr Gly Tyr Gly Pro Gly Gly Val Ala Gly Ala Ala Gly Lys Ala 
        195                 200                 205             


Gly Tyr Pro Thr Gly Thr 
    210                 


<210>  4692
<211>  167
<212>  PRT
<213>  Homo Sapiens

<400>  4692

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30          


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45              


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60                  


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly 
65                  70                  75                  80  


Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Val 
                85                  90                  95      


Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala Gly Val Gly Pro 
            100                 105                 110         


Phe Gly Gly Pro Gln Pro Gly Val Pro Leu Gly Tyr Pro Ile Lys Ala 
        115                 120                 125             


Pro Lys Leu Pro Gly Gly Tyr Gly Leu Pro Tyr Thr Thr Gly Lys Leu 
    130                 135                 140                 


Pro Tyr Gly Tyr Gly Pro Gly Gly Val Ala Gly Ala Ala Gly Lys Ala 
145                 150                 155                 160 


Gly Tyr Pro Thr Gly Thr Gly 
                165         


<210>  4693
<211>  570
<212>  PRT
<213>  Homo Sapiens

<400>  4693

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30          


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45              


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60                  


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Val Gly 
65                  70                  75                  80  


Gly Ala Phe Ala Gly Ile Pro Gly Val Gly Pro Phe Gly Gly Pro Gln 
                85                  90                  95      


Pro Gly Val Pro Leu Gly Tyr Pro Ile Lys Ala Pro Lys Leu Pro Gly 
            100                 105                 110         


Tyr Gly Pro Gly Gly Val Ala Gly Ala Ala Gly Lys Ala Gly Tyr Pro 
        115                 120                 125             


Thr Gly Thr Gly Val Gly Pro Gln Ala Ala Ala Ala Ala Ala Ala Lys 
    130                 135                 140                 


Ala Ala Ala Lys Phe Gly Ala Gly Ala Ala Gly Val Leu Pro Gly Val 
145                 150                 155                 160 


Gly Gly Ala Gly Val Pro Gly Val Pro Gly Ala Ile Pro Gly Ile Gly 
                165                 170                 175     


Gly Ile Ala Gly Val Gly Thr Pro Ala Ala Ala Ala Ala Ala Ala Ala 
            180                 185                 190         


Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Ala Gly Leu Val Pro Gly 
        195                 200                 205             


Gly Pro Gly Phe Gly Pro Gly Val Val Gly Val Pro Gly Ala Gly Val 
    210                 215                 220                 


Pro Gly Val Gly Val Pro Gly Ala Gly Ile Pro Val Val Pro Gly Ala 
225                 230                 235                 240 


Gly Ile Pro Gly Ala Ala Val Pro Gly Val Val Ser Pro Glu Ala Ala 
                245                 250                 255     


Ala Lys Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Arg Pro Gly Val 
            260                 265                 270         


Gly Val Gly Gly Ile Pro Thr Tyr Gly Val Gly Ala Gly Gly Phe Pro 
        275                 280                 285             


Gly Phe Gly Val Gly Val Gly Gly Ile Pro Gly Val Ala Gly Val Pro 
    290                 295                 300                 


Gly Val Gly Gly Val Pro Gly Val Gly Gly Val Pro Gly Val Gly Ile 
305                 310                 315                 320 


Ser Pro Glu Ala Gln Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly 
                325                 330                 335     


Leu Val Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly 
            340                 345                 350         


Val Gly Val Ala Pro Gly Val Gly Leu Ala Pro Gly Val Gly Val Ala 
        355                 360                 365             


Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Ile Gly 
    370                 375                 380                 


Pro Gly Gly Val Ala Ala Ala Ala Lys Ser Ala Ala Lys Val Ala Ala 
385                 390                 395                 400 


Lys Ala Gln Leu Arg Ala Ala Ala Gly Leu Gly Ala Gly Ile Pro Gly 
                405                 410                 415     


Leu Gly Val Gly Val Gly Val Pro Gly Leu Gly Val Gly Ala Gly Val 
            420                 425                 430         


Pro Gly Leu Gly Val Gly Ala Gly Val Pro Gly Phe Gly Ala Val Pro 
        435                 440                 445             


Gly Ala Leu Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Val Pro 
    450                 455                 460                 


Gly Val Leu Gly Gly Leu Gly Ala Leu Gly Gly Val Gly Ile Pro Gly 
465                 470                 475                 480 


Gly Val Val Gly Ala Gly Pro Ala Ala Ala Ala Ala Ala Ala Lys Ala 
                485                 490                 495     


Ala Ala Lys Ala Ala Gln Phe Gly Leu Val Gly Ala Ala Gly Leu Gly 
            500                 505                 510         


Gly Leu Gly Val Gly Gly Leu Gly Val Pro Gly Val Gly Gly Leu Gly 
        515                 520                 525             


Gly Ile Pro Pro Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Val Ala 
    530                 535                 540                 


Ala Arg Pro Gly Phe Gly Leu Ser Pro Ile Phe Pro Gly Gly Ala Cys 
545                 550                 555                 560 


Leu Gly Lys Ala Cys Gly Arg Lys Arg Lys 
                565                 570 


<210>  4694
<211>  68
<212>  PRT
<213>  Homo Sapiens

<400>  4694

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30          


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Asn Val His 
        35                  40                  45              


Glu Thr Ser Thr His Pro Gly His Ala Asp Asp Ala Asp Val His Asn 
    50                  55                  60                  


Arg Cys Thr Phe 
65              


<210>  4695
<211>  60
<212>  PRT
<213>  Homo Sapiens

<400>  4695

Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Val Ala Asp Ala Ala 
1               5                   10                  15      


Ala Ala Tyr Lys Ala Ala Lys Ala Gly Ala Gly Leu Gly Gly Val Pro 
            20                  25                  30          


Gly Val Gly Gly Leu Gly Val Ser Ala Gly Ala Val Val Pro Gln Pro 
        35                  40                  45              


Gly Ala Gly Val Lys Pro Gly Lys Val Pro Ala Leu 
    50                  55                  60  


<210>  4696
<211>  47
<212>  PRT
<213>  Homo Sapiens

<400>  4696

Asp Glu Glu Glu Leu Leu Thr Ser Thr Gly Phe Glu Tyr Gln Gln Val 
1               5                   10                  15      


Ala Phe Gln Pro Ser Ile Leu Thr Glu Pro Pro Thr Glu Asp His Leu 
            20                  25                  30          


Leu Gln Asn Thr Leu Trp Pro Glu Val Gln Lys Leu Ala Ser Phe 
        35                  40                  45          


<210>  4697
<211>  57
<212>  PRT
<213>  Homo Sapiens

<400>  4697

Met Cys Leu Gln Thr Leu Asn Phe Gly Asn Gly Phe Ala Leu Ala Leu 
1               5                   10                  15      


Cys Leu Ser Phe Leu Pro Asn Thr Asp Val Pro Ile Leu Ala Cys Gly 
            20                  25                  30          


Asn Asp Asp Cys Arg Ile His Ile Phe Ala Gln Gln Asn Asp Gln Phe 
        35                  40                  45              


Gln Lys Val Leu Ser Leu Cys Gly His 
    50                  55          


<210>  4698
<211>  120
<212>  PRT
<213>  Homo Sapiens

<400>  4698

Met Val Ala Pro Val Leu Glu Thr Ser His Val Phe Cys Cys Pro Asn 
1               5                   10                  15      


Arg Val Arg Gly Val Leu Asn Trp Ser Ser Gly Pro Arg Gly Leu Leu 
            20                  25                  30          


Ala Phe Gly Thr Ser Cys Ser Val Val Leu Tyr Asp Pro Leu Lys Arg 
        35                  40                  45              


Val Val Val Thr Asn Leu Asn Gly His Thr Ala Arg Val Asn Cys Ile 
    50                  55                  60                  


Gln Trp Ile Cys Lys Gln Asp Gly Ser Pro Ser Thr Glu Leu Val Ser 
65                  70                  75                  80  


Gly Gly Ser Asp Asn Gln Val Ile His Trp Glu Ile Glu Asp Asn Gln 
                85                  90                  95      


Ala Met Lys Asp Leu Phe Met Arg Cys Met Leu Phe Thr Arg Gly Gly 
            100                 105                 110         


His Gln Ile Leu His Tyr Val His 
        115                 120 


<210>  4699
<211>  101
<212>  PRT
<213>  Homo Sapiens

<400>  4699

Met Val Ala Pro Val Leu Glu Thr Ser His Val Phe Cys Cys Pro Asn 
1               5                   10                  15      


Arg Val Arg Gly Val Leu Asn Trp Ser Ser Gly Pro Arg Gly Leu Leu 
            20                  25                  30          


Ala Phe Gly Thr Ser Cys Ser Val Val Leu Tyr Asp Pro Leu Lys Arg 
        35                  40                  45              


Val Val Val Thr Asn Leu Asn Gly His Thr Ala Arg Val Asn Cys Ile 
    50                  55                  60                  


Gln Trp Ile Cys Lys Gln Asp Gly Ser Pro Ser Thr Glu Leu Val Ser 
65                  70                  75                  80  


Gly Gly Ser Asp Asn Gln Val Ile His Trp Glu Ile Glu Asp Asn Gln 
                85                  90                  95      


Ile Trp Ala Arg Leu 
            100     


<210>  4700
<211>  756
<212>  PRT
<213>  Homo Sapiens

<400>  4700

Met Val Ala Pro Val Leu Glu Thr Ser His Val Phe Cys Cys Pro Asn 
1               5                   10                  15      


Arg Val Arg Gly Val Leu Asn Trp Ser Ser Gly Pro Arg Gly Leu Leu 
            20                  25                  30          


Ala Phe Gly Thr Ser Cys Ser Val Val Leu Tyr Asp Pro Leu Lys Arg 
        35                  40                  45              


Val Val Val Thr Asn Leu Asn Gly His Thr Ala Arg Val Asn Cys Ile 
    50                  55                  60                  


Gln Trp Ile Cys Lys Gln Asp Gly Ser Pro Ser Thr Glu Leu Val Ser 
65                  70                  75                  80  


Gly Gly Ser Asp Asn Gln Val Ile His Trp Glu Ile Glu Asp Asn Gln 
                85                  90                  95      


Leu Leu Lys Ala Val His Leu Gln Gly His Glu Gly Pro Val Tyr Ala 
            100                 105                 110         


Val His Ala Val Tyr Gln Arg Arg Thr Ser Asp Pro Ala Leu Cys Thr 
        115                 120                 125             


Leu Ile Val Ser Ala Ala Ala Asp Ser Ala Val Arg Leu Trp Ser Lys 
    130                 135                 140                 


Lys Gly Pro Glu Gly Arg Asp Leu Phe Leu Ala Ser Cys Ser Gln Asp 
145                 150                 155                 160 


Cys Leu Ile Arg Ile Trp Lys Leu Tyr Ile Lys Ser Thr Ser Leu Glu 
                165                 170                 175     


Thr Gln Asp Asp Asp Asn Ile Arg Leu Lys Glu Asn Thr Phe Thr Ile 
            180                 185                 190         


Glu Asn Glu Ser Val Lys Ile Ala Phe Ala Val Thr Leu Glu Thr Val 
        195                 200                 205             


Leu Ala Gly His Glu Asn Trp Val Asn Ala Val His Trp Gln Pro Val 
    210                 215                 220                 


Phe Tyr Lys Asp Gly Val Leu Gln Gln Pro Val Arg Leu Leu Ser Ala 
225                 230                 235                 240 


Ser Met Asp Lys Thr Met Ile Leu Trp Ala Pro Asp Glu Glu Ser Gly 
                245                 250                 255     


Val Trp Leu Glu Gln Val Arg Val Gly Glu Val Gly Gly Asn Thr Leu 
            260                 265                 270         


Gly Phe Tyr Asp Cys Gln Phe Asn Glu Asp Gly Ser Met Ile Ile Ala 
        275                 280                 285             


His Ala Phe His Gly Ala Leu His Leu Trp Lys Gln Asn Thr Val Asn 
    290                 295                 300                 


Pro Arg Glu Trp Thr Pro Glu Ile Val Ile Ser Gly His Phe Asp Gly 
305                 310                 315                 320 


Val Gln Asp Leu Val Trp Asp Pro Glu Gly Glu Phe Ile Ile Thr Val 
                325                 330                 335     


Gly Thr Asp Gln Thr Thr Arg Leu Phe Ala Pro Trp Lys Arg Lys Asp 
            340                 345                 350         


Gln Ser Gln Val Thr Trp His Glu Ile Ala Arg Pro Gln Ile His Gly 
        355                 360                 365             


Tyr Asp Leu Lys Cys Leu Ala Met Ile Asn Arg Phe Gln Phe Val Ser 
    370                 375                 380                 


Gly Ala Asp Glu Lys Val Leu Arg Val Phe Ser Ala Pro Arg Asn Phe 
385                 390                 395                 400 


Val Glu Asn Phe Cys Ala Ile Thr Gly Gln Ser Leu Asn His Val Leu 
                405                 410                 415     


Cys Asn Gln Asp Ser Asp Leu Pro Glu Gly Ala Thr Val Pro Ala Leu 
            420                 425                 430         


Gly Leu Ser Asn Lys Ala Val Phe Gln Gly Asp Ile Ala Ser Gln Pro 
        435                 440                 445             


Ser Asp Glu Glu Glu Leu Leu Thr Ser Thr Gly Phe Glu Tyr Gln Gln 
    450                 455                 460                 


Val Ala Phe Gln Pro Ser Ile Leu Thr Glu Pro Pro Thr Glu Asp His 
465                 470                 475                 480 


Leu Leu Gln Asn Thr Leu Trp Pro Glu Val Gln Lys Leu Tyr Gly His 
                485                 490                 495     


Gly Tyr Glu Ile Phe Cys Val Thr Cys Asn Ser Ser Lys Thr Leu Leu 
            500                 505                 510         


Ala Ser Ala Cys Lys Ala Ala Lys Lys Glu His Ala Ala Ile Ile Leu 
        515                 520                 525             


Trp Asn Thr Thr Ser Trp Lys Gln Val Gln Asn Leu Val Phe His Ser 
    530                 535                 540                 


Leu Thr Val Thr Gln Met Ala Phe Ser Pro Asn Glu Lys Phe Leu Leu 
545                 550                 555                 560 


Ala Val Ser Arg Asp Arg Thr Trp Ser Leu Trp Lys Lys Gln Asp Thr 
                565                 570                 575     


Ile Ser Pro Glu Phe Glu Pro Val Phe Ser Leu Phe Ala Phe Thr Asn 
            580                 585                 590         


Lys Ile Thr Ser Val His Ser Arg Ile Ile Trp Ser Cys Asp Trp Ser 
        595                 600                 605             


Pro Asp Ser Lys Tyr Phe Phe Thr Gly Ser Arg Asp Lys Lys Val Val 
    610                 615                 620                 


Val Trp Gly Glu Cys Asp Ser Thr Asp Asp Cys Ile Glu His Asn Ile 
625                 630                 635                 640 


Gly Pro Cys Ser Ser Val Leu Asp Val Gly Gly Ala Val Thr Ala Val 
                645                 650                 655     


Ser Val Cys Pro Val Leu His Pro Ser Gln Arg Tyr Val Val Ala Val 
            660                 665                 670         


Gly Leu Glu Cys Gly Lys Ile Cys Leu Tyr Thr Trp Lys Lys Thr Asp 
        675                 680                 685             


Gln Val Pro Glu Ile Asn Asp Trp Thr His Cys Val Glu Thr Ser Gln 
    690                 695                 700                 


Ser Gln Ser His Thr Leu Ala Ile Arg Lys Leu Cys Trp Lys Asn Cys 
705                 710                 715                 720 


Ser Gly Lys Thr Glu Gln Lys Glu Ala Glu Gly Ala Glu Trp Leu His 
                725                 730                 735     


Phe Ala Ser Cys Gly Glu Asp His Thr Val Lys Ile His Arg Val Asn 
            740                 745                 750         


Lys Cys Ala Leu 
        755     


<210>  4701
<211>  826
<212>  PRT
<213>  Homo Sapiens

<400>  4701

Met Val Ala Pro Val Leu Glu Thr Ser His Val Phe Cys Cys Pro Asn 
1               5                   10                  15      


Arg Val Arg Gly Val Leu Asn Trp Ser Ser Gly Pro Arg Gly Leu Leu 
            20                  25                  30          


Ala Phe Gly Thr Ser Cys Ser Val Val Leu Tyr Asp Pro Leu Lys Arg 
        35                  40                  45              


Val Val Val Thr Asn Leu Asn Gly His Thr Ala Arg Val Asn Cys Ile 
    50                  55                  60                  


Gln Trp Ile Cys Lys Gln Asp Gly Ser Pro Ser Thr Glu Leu Val Ser 
65                  70                  75                  80  


Gly Gly Ser Asp Asn Gln Val Ile His Trp Glu Ile Glu Asp Asn Gln 
                85                  90                  95      


Leu Leu Lys Ala Val His Leu Gln Gly His Glu Gly Pro Val Tyr Ala 
            100                 105                 110         


Val His Ala Val Tyr Gln Arg Arg Thr Ser Asp Pro Ala Leu Cys Thr 
        115                 120                 125             


Leu Ile Val Ser Ala Ala Ala Asp Ser Ala Val Arg Leu Trp Ser Lys 
    130                 135                 140                 


Lys Gly Pro Glu Val Met Cys Leu Gln Thr Leu Asn Phe Gly Asn Gly 
145                 150                 155                 160 


Phe Ala Leu Ala Leu Cys Leu Ser Phe Leu Pro Asn Thr Asp Val Pro 
                165                 170                 175     


Ile Leu Ala Cys Gly Asn Asp Asp Cys Arg Ile His Ile Phe Ala Gln 
            180                 185                 190         


Gln Asn Asp Gln Phe Gln Lys Val Leu Ser Leu Cys Gly His Glu Asp 
        195                 200                 205             


Trp Ile Arg Gly Val Glu Trp Ala Ala Phe Gly Arg Asp Leu Phe Leu 
    210                 215                 220                 


Ala Ser Cys Ser Gln Asp Cys Leu Ile Arg Ile Trp Lys Leu Tyr Ile 
225                 230                 235                 240 


Lys Ser Thr Ser Leu Glu Thr Gln Asp Asp Asp Asn Ile Arg Leu Lys 
                245                 250                 255     


Glu Asn Thr Phe Thr Ile Glu Asn Glu Ser Val Lys Ile Ala Phe Ala 
            260                 265                 270         


Val Thr Leu Glu Thr Val Leu Ala Gly His Glu Asn Trp Val Asn Ala 
        275                 280                 285             


Val His Trp Gln Pro Val Phe Tyr Lys Asp Gly Val Leu Gln Gln Pro 
    290                 295                 300                 


Val Arg Leu Leu Ser Ala Ser Met Asp Lys Thr Met Ile Leu Trp Ala 
305                 310                 315                 320 


Pro Asp Glu Glu Ser Gly Val Trp Leu Glu Gln Val Arg Val Gly Glu 
                325                 330                 335     


Val Gly Gly Asn Thr Leu Gly Phe Tyr Asp Cys Gln Phe Asn Glu Asp 
            340                 345                 350         


Gly Ser Met Ile Ile Ala His Ala Phe His Gly Ala Leu His Leu Trp 
        355                 360                 365             


Lys Gln Asn Thr Val Asn Pro Arg Glu Trp Thr Pro Glu Ile Val Ile 
    370                 375                 380                 


Ser Gly His Phe Asp Gly Val Gln Asp Leu Val Trp Asp Pro Glu Gly 
385                 390                 395                 400 


Glu Phe Ile Ile Thr Val Gly Thr Asp Gln Thr Thr Arg Leu Phe Ala 
                405                 410                 415     


Pro Trp Lys Arg Lys Asp Gln Ser Gln Val Thr Trp His Glu Ile Ala 
            420                 425                 430         


Arg Pro Gln Ile His Gly Tyr Asp Leu Lys Cys Leu Ala Met Ile Asn 
        435                 440                 445             


Arg Phe Gln Phe Val Ser Gly Ala Asp Glu Lys Val Leu Arg Val Phe 
    450                 455                 460                 


Ser Ala Pro Arg Asn Phe Val Glu Asn Phe Cys Ala Ile Thr Gly Gln 
465                 470                 475                 480 


Ser Leu Asn His Val Leu Cys Asn Gln Asp Ser Asp Leu Pro Glu Gly 
                485                 490                 495     


Ala Thr Val Pro Ala Leu Gly Leu Ser Asn Lys Ala Val Phe Gln Gly 
            500                 505                 510         


Asp Ile Ala Ser Gln Pro Ser Asp Glu Glu Glu Leu Leu Thr Ser Thr 
        515                 520                 525             


Gly Phe Glu Tyr Gln Gln Val Ala Phe Gln Pro Ser Ile Leu Thr Glu 
    530                 535                 540                 


Pro Pro Thr Glu Asp His Leu Leu Gln Asn Thr Leu Trp Pro Glu Val 
545                 550                 555                 560 


Gln Lys Leu Tyr Gly His Gly Tyr Glu Ile Phe Cys Val Thr Cys Asn 
                565                 570                 575     


Ser Ser Lys Thr Leu Leu Ala Ser Ala Cys Lys Ala Ala Lys Lys Glu 
            580                 585                 590         


His Ala Ala Ile Ile Leu Trp Asn Thr Thr Ser Trp Lys Gln Val Gln 
        595                 600                 605             


Asn Leu Val Phe His Ser Leu Thr Val Thr Gln Met Ala Phe Ser Pro 
    610                 615                 620                 


Asn Glu Lys Phe Leu Leu Ala Val Ser Arg Asp Arg Thr Trp Ser Leu 
625                 630                 635                 640 


Trp Lys Lys Gln Asp Thr Ile Ser Pro Glu Phe Glu Pro Val Phe Ser 
                645                 650                 655     


Leu Phe Ala Phe Thr Asn Lys Ile Thr Ser Val His Ser Arg Ile Ile 
            660                 665                 670         


Trp Ser Cys Asp Trp Ser Pro Asp Ser Lys Tyr Phe Phe Thr Gly Ser 
        675                 680                 685             


Arg Asp Lys Lys Val Val Val Trp Gly Glu Cys Asp Ser Thr Asp Asp 
    690                 695                 700                 


Cys Ile Glu His Asn Ile Gly Pro Cys Ser Ser Val Leu Asp Val Gly 
705                 710                 715                 720 


Gly Ala Val Thr Ala Val Ser Val Cys Pro Val Leu His Pro Ser Gln 
                725                 730                 735     


Arg Tyr Val Val Ala Val Gly Leu Glu Cys Gly Lys Ile Cys Leu Tyr 
            740                 745                 750         


Thr Trp Lys Lys Thr Asp Gln Val Pro Glu Ile Asn Asp Trp Thr His 
        755                 760                 765             


Cys Val Glu Thr Ser Gln Ser Gln Ser His Thr Leu Ala Ile Arg Lys 
    770                 775                 780                 


Leu Cys Trp Lys Asn Cys Ser Gly Lys Thr Glu Gln Lys Glu Ala Glu 
785                 790                 795                 800 


Gly Ala Glu Trp Leu His Phe Ala Ser Cys Gly Glu Asp His Thr Val 
                805                 810                 815     


Lys Ile His Arg Val Asn Lys Cys Ala Leu 
            820                 825     


<210>  4702
<211>  705
<212>  PRT
<213>  Homo Sapiens

<400>  4702

Met Val Ala Pro Val Leu Glu Thr Ser His Val Phe Cys Cys Pro Asn 
1               5                   10                  15      


Arg Val Arg Gly Val Leu Asn Trp Ser Ser Gly Pro Arg Gly Leu Leu 
            20                  25                  30          


Ala Phe Gly Thr Ser Cys Ser Val Val Leu Tyr Asp Pro Leu Lys Arg 
        35                  40                  45              


Val Val Val Thr Asn Leu Asn Gly His Thr Ala Arg Val Asn Cys Ile 
    50                  55                  60                  


Gln Trp Ile Cys Lys Gln Asp Gly Ser Pro Ser Thr Glu Leu Val Ser 
65                  70                  75                  80  


Gly Gly Ser Asp Asn Gln Val Ile His Trp Glu Ile Glu Asp Asn Gln 
                85                  90                  95      


Leu Leu Lys Ala Val His Leu Gln Gly His Glu Gly Pro Val Tyr Ala 
            100                 105                 110         


Val His Ala Val Tyr Gln Arg Arg Thr Ser Asp Pro Ala Leu Cys Thr 
        115                 120                 125             


Leu Ile Val Ser Ala Ala Ala Asp Ser Ala Val Arg Leu Trp Ser Lys 
    130                 135                 140                 


Lys Gly Pro Glu Val Met Cys Leu Gln Thr Leu Asn Phe Gly Asn Gly 
145                 150                 155                 160 


Phe Ala Leu Ala Leu Cys Leu Ser Phe Leu Pro Asn Thr Asp Val Pro 
                165                 170                 175     


Ile Leu Ala Cys Gly Asn Asp Asp Cys Arg Ile His Ile Phe Ala Gln 
            180                 185                 190         


Gln Asn Asp Gln Phe Gln Lys Val Leu Ser Leu Cys Gly His Glu Asp 
        195                 200                 205             


Trp Ile Arg Gly Val Glu Trp Ala Ala Phe Gly Arg Asp Leu Phe Leu 
    210                 215                 220                 


Ala Ser Cys Ser Gln Asp Cys Leu Ile Arg Ile Trp Lys Leu Tyr Ile 
225                 230                 235                 240 


Lys Ser Thr Ser Leu Glu Thr Gln Asp Asp Asp Asn Ile Arg Leu Lys 
                245                 250                 255     


Glu Asn Thr Phe Thr Ile Glu Asn Glu Ser Val Lys Ile Ala Phe Ala 
            260                 265                 270         


Val Thr Leu Glu Thr Val Leu Ala Gly His Glu Asn Trp Val Asn Ala 
        275                 280                 285             


Val His Trp Gln Pro Val Phe Tyr Lys Asp Gly Val Leu Gln Gln Pro 
    290                 295                 300                 


Val Arg Leu Leu Ser Ala Ser Met Asp Lys Thr Met Ile Leu Trp Ala 
305                 310                 315                 320 


Pro Asp Glu Glu Ser Gly Val Trp Leu Glu Gln Val Arg Val Gly Glu 
                325                 330                 335     


Val Gly Gly Asn Thr Leu Gly Phe Tyr Asp Cys Gln Phe Asn Glu Asp 
            340                 345                 350         


Gly Ser Met Ile Ile Ala His Ala Phe His Gly Ala Leu His Leu Trp 
        355                 360                 365             


Lys Gln Asn Thr Val Asn Pro Arg Glu Trp Thr Pro Glu Ile Val Ile 
    370                 375                 380                 


Ser Gly His Phe Asp Gly Val Gln Asp Leu Val Trp Asp Pro Glu Gly 
385                 390                 395                 400 


Glu Phe Ile Ile Thr Val Gly Thr Asp Gln Thr Thr Arg Leu Phe Ala 
                405                 410                 415     


Pro Trp Lys Arg Lys Asp Gln Ser Gln Val Thr Trp His Glu Ile Ala 
            420                 425                 430         


Arg Pro Gln Ile His Gly Tyr Asp Leu Lys Cys Leu Ala Met Ile Asn 
        435                 440                 445             


Arg Phe Gln Phe Val Ser Gly Ala Asp Glu Lys Val Leu Arg Val Phe 
    450                 455                 460                 


Ser Ala Pro Arg Asn Phe Val Glu Asn Phe Cys Ala Ile Thr Gly Gln 
465                 470                 475                 480 


Ser Leu Asn His Val Leu Cys Asn Gln Asp Ser Asp Leu Pro Glu Gly 
                485                 490                 495     


Ala Thr Val Pro Ala Leu Gly Leu Ser Asn Lys Ala Val Phe Gln Gly 
            500                 505                 510         


Asp Ile Ala Ser Gln Pro Ser Asp Glu Glu Glu Leu Leu Thr Ser Thr 
        515                 520                 525             


Gly Phe Glu Tyr Gln Gln Val Ala Phe Gln Pro Ser Ile Leu Thr Glu 
    530                 535                 540                 


Pro Pro Thr Glu Asp His Leu Leu Gln Asn Thr Leu Trp Pro Glu Val 
545                 550                 555                 560 


Gln Lys Leu Tyr Gly His Gly Tyr Glu Ile Phe Cys Val Thr Cys Asn 
                565                 570                 575     


Ser Ser Lys Thr Leu Leu Ala Ser Ala Cys Lys Ala Ala Lys Lys Glu 
            580                 585                 590         


His Ala Ala Ile Ile Leu Trp Asn Thr Thr Ser Trp Lys Gln Val Gln 
        595                 600                 605             


Asn Leu Val Phe His Ser Leu Thr Val Thr Gln Met Ala Phe Ser Pro 
    610                 615                 620                 


Asn Glu Lys Phe Leu Leu Ala Val Ser Arg Asp Arg Thr Trp Ser Leu 
625                 630                 635                 640 


Trp Lys Lys Gln Asp Thr Ile Ser Pro Glu Phe Val Glu Leu Phe Gly 
                645                 650                 655     


Leu Val Ile Gly Val Leu Thr Ala Ser Ile Ser Ser Leu Gly Val Glu 
            660                 665                 670         


Thr Lys Arg Trp Leu Ser Gly Val Ser Ala Thr Pro Leu Met Thr Val 
        675                 680                 685             


Leu Ser Thr Thr Leu Ala Pro Ala Pro Gln Ser Trp Thr Trp Val Gly 
    690                 695                 700                 


Leu 
705 


<210>  4703
<211>  891
<212>  PRT
<213>  Homo Sapiens

<400>  4703

Met Val Ala Pro Val Leu Glu Thr Ser His Val Phe Cys Cys Pro Asn 
1               5                   10                  15      


Arg Val Arg Gly Val Leu Asn Trp Ser Ser Gly Pro Arg Gly Leu Leu 
            20                  25                  30          


Ala Phe Gly Thr Ser Cys Ser Val Val Leu Tyr Asp Pro Leu Lys Arg 
        35                  40                  45              


Val Val Val Thr Asn Leu Asn Gly His Thr Ala Arg Val Asn Cys Ile 
    50                  55                  60                  


Gln Trp Ile Cys Lys Gln Asp Gly Ser Pro Ser Thr Glu Leu Val Ser 
65                  70                  75                  80  


Gly Gly Ser Asp Asn Gln Val Ile His Trp Glu Ile Glu Asp Asn Gln 
                85                  90                  95      


Leu Leu Lys Ala Val His Leu Gln Gly His Glu Gly Pro Val Tyr Ala 
            100                 105                 110         


Val His Ala Val Tyr Gln Arg Arg Thr Ser Asp Pro Ala Leu Cys Thr 
        115                 120                 125             


Leu Ile Val Ser Ala Ala Ala Asp Ser Ala Val Arg Leu Trp Ser Lys 
    130                 135                 140                 


Lys Gly Pro Glu Val Met Cys Leu Gln Thr Leu Asn Phe Gly Asn Gly 
145                 150                 155                 160 


Phe Ala Leu Ala Leu Cys Leu Ser Phe Leu Pro Asn Thr Asp Val Thr 
                165                 170                 175     


Trp Lys Thr Gly Gln Val Glu Arg Gly Arg Ala Trp Lys Pro Pro Ala 
            180                 185                 190         


Ser Leu Ala Leu Cys Ser Arg Ser Cys Asp Ser Met Val Ser Cys Tyr 
        195                 200                 205             


Ala Ser Ile Leu Cys Lys Ala Leu Trp Lys Glu Lys Leu His Thr Phe 
    210                 215                 220                 


Trp His His Asn Arg Ile Ser Phe Leu Pro Ser Ala Phe Arg Pro Ile 
225                 230                 235                 240 


Pro Ile Leu Ala Cys Gly Asn Asp Asp Cys Arg Ile His Ile Phe Ala 
                245                 250                 255     


Gln Gln Asn Asp Gln Phe Gln Lys Val Leu Ser Leu Cys Gly His Glu 
            260                 265                 270         


Asp Trp Ile Arg Gly Val Glu Trp Ala Ala Phe Gly Arg Asp Leu Phe 
        275                 280                 285             


Leu Ala Ser Cys Ser Gln Asp Cys Leu Ile Arg Ile Trp Lys Leu Tyr 
    290                 295                 300                 


Ile Lys Ser Thr Ser Leu Glu Thr Gln Asp Asp Asp Asn Ile Arg Leu 
305                 310                 315                 320 


Lys Glu Asn Thr Phe Thr Ile Glu Asn Glu Ser Val Lys Ile Ala Phe 
                325                 330                 335     


Ala Val Thr Leu Glu Thr Val Leu Ala Gly His Glu Asn Trp Val Asn 
            340                 345                 350         


Ala Val His Trp Gln Pro Val Phe Tyr Lys Asp Gly Val Leu Gln Gln 
        355                 360                 365             


Pro Val Arg Leu Leu Ser Ala Ser Met Asp Lys Thr Met Ile Leu Trp 
    370                 375                 380                 


Ala Pro Asp Glu Glu Ser Gly Val Trp Leu Glu Gln Val Arg Val Gly 
385                 390                 395                 400 


Glu Val Gly Gly Asn Thr Leu Gly Phe Tyr Asp Cys Gln Phe Asn Glu 
                405                 410                 415     


Asp Gly Ser Met Ile Ile Ala His Ala Phe His Gly Ala Leu His Leu 
            420                 425                 430         


Trp Lys Gln Asn Thr Val Asn Pro Arg Glu Trp Thr Pro Glu Ile Val 
        435                 440                 445             


Ile Ser Gly His Phe Asp Gly Val Gln Asp Leu Val Trp Asp Pro Glu 
    450                 455                 460                 


Gly Glu Phe Ile Ile Thr Val Gly Thr Asp Gln Thr Thr Arg Leu Phe 
465                 470                 475                 480 


Ala Pro Trp Lys Arg Lys Asp Gln Ser Gln Val Thr Trp His Glu Ile 
                485                 490                 495     


Ala Arg Pro Gln Ile His Gly Tyr Asp Leu Lys Cys Leu Ala Met Ile 
            500                 505                 510         


Asn Arg Phe Gln Phe Val Ser Gly Ala Asp Glu Lys Val Leu Arg Val 
        515                 520                 525             


Phe Ser Ala Pro Arg Asn Phe Val Glu Asn Phe Cys Ala Ile Thr Gly 
    530                 535                 540                 


Gln Ser Leu Asn His Val Leu Cys Asn Gln Asp Ser Asp Leu Pro Glu 
545                 550                 555                 560 


Gly Ala Thr Val Pro Ala Leu Gly Leu Ser Asn Lys Ala Val Phe Gln 
                565                 570                 575     


Gly Asp Ile Ala Ser Gln Pro Ser Asp Glu Glu Glu Leu Leu Thr Ser 
            580                 585                 590         


Thr Gly Phe Glu Tyr Gln Gln Val Ala Phe Gln Pro Ser Ile Leu Thr 
        595                 600                 605             


Glu Pro Pro Thr Glu Asp His Leu Leu Gln Asn Thr Leu Trp Pro Glu 
    610                 615                 620                 


Val Gln Lys Leu Tyr Gly His Gly Tyr Glu Ile Phe Cys Val Thr Cys 
625                 630                 635                 640 


Asn Ser Ser Lys Thr Leu Leu Ala Ser Ala Cys Lys Ala Ala Lys Lys 
                645                 650                 655     


Glu His Ala Ala Ile Ile Leu Trp Asn Thr Thr Ser Trp Lys Gln Val 
            660                 665                 670         


Gln Asn Leu Val Phe His Ser Leu Thr Val Thr Gln Met Ala Phe Ser 
        675                 680                 685             


Pro Asn Glu Lys Phe Leu Leu Ala Val Ser Arg Asp Arg Thr Trp Ser 
    690                 695                 700                 


Leu Trp Lys Lys Gln Asp Thr Ile Ser Pro Glu Phe Glu Pro Val Phe 
705                 710                 715                 720 


Ser Leu Phe Ala Phe Thr Asn Lys Ile Thr Ser Val His Ser Arg Ile 
                725                 730                 735     


Ile Trp Ser Cys Asp Trp Ser Pro Asp Ser Lys Tyr Phe Phe Thr Gly 
            740                 745                 750         


Ser Arg Asp Lys Lys Val Val Val Trp Gly Glu Cys Asp Ser Thr Asp 
        755                 760                 765             


Asp Cys Ile Glu His Asn Ile Gly Pro Cys Ser Ser Val Leu Asp Val 
    770                 775                 780                 


Gly Gly Ala Val Thr Ala Val Ser Val Cys Pro Val Leu His Pro Ser 
785                 790                 795                 800 


Gln Arg Tyr Val Val Ala Val Gly Leu Glu Cys Gly Lys Ile Cys Leu 
                805                 810                 815     


Tyr Thr Trp Lys Lys Thr Asp Gln Val Pro Glu Ile Asn Asp Trp Thr 
            820                 825                 830         


His Cys Val Glu Thr Ser Gln Ser Gln Ser His Thr Leu Ala Ile Arg 
        835                 840                 845             


Lys Leu Cys Trp Lys Asn Cys Ser Gly Lys Thr Glu Gln Lys Glu Ala 
    850                 855                 860                 


Glu Gly Ala Glu Trp Leu His Phe Ala Ser Cys Gly Glu Asp His Thr 
865                 870                 875                 880 


Val Lys Ile His Arg Val Asn Lys Cys Ala Leu 
                885                 890     


<210>  4704
<211>  800
<212>  PRT
<213>  Homo Sapiens

<400>  4704

Met Val Ala Pro Val Leu Glu Thr Ser His Val Phe Cys Cys Pro Asn 
1               5                   10                  15      


Arg Val Arg Gly Val Leu Asn Trp Ser Ser Gly Pro Arg Gly Leu Leu 
            20                  25                  30          


Ala Phe Gly Thr Ser Cys Ser Val Val Leu Tyr Asp Pro Leu Lys Arg 
        35                  40                  45              


Val Val Val Thr Asn Leu Asn Gly His Thr Ala Arg Val Asn Cys Ile 
    50                  55                  60                  


Gln Trp Ile Cys Lys Gln Asp Gly Ser Pro Ser Thr Glu Leu Val Ser 
65                  70                  75                  80  


Gly Gly Ser Asp Asn Gln Val Ile His Trp Glu Ile Glu Asp Asn Gln 
                85                  90                  95      


Leu Leu Lys Ala Val His Leu Gln Gly His Glu Gly Pro Val Tyr Ala 
            100                 105                 110         


Val His Ala Val Tyr Gln Arg Arg Thr Ser Asp Pro Ala Leu Cys Thr 
        115                 120                 125             


Leu Ile Val Ser Ala Ala Ala Asp Ser Ala Val Arg Leu Trp Ser Lys 
    130                 135                 140                 


Lys Gly Pro Glu Val Pro Ile Leu Ala Cys Gly Asn Asp Asp Cys Arg 
145                 150                 155                 160 


Ile His Ile Phe Ala Gln Gln Asn Asp Gln Phe Gln Lys Val Leu Ser 
                165                 170                 175     


Leu Cys Gly His Glu Asp Trp Ile Arg Gly Val Glu Trp Ala Ala Phe 
            180                 185                 190         


Gly Arg Asp Leu Phe Leu Ala Ser Cys Ser Gln Asp Cys Leu Ile Arg 
        195                 200                 205             


Ile Trp Lys Leu Tyr Ile Lys Ser Thr Ser Leu Glu Thr Gln Asp Asp 
    210                 215                 220                 


Asp Asn Ile Arg Leu Lys Glu Asn Thr Phe Thr Ile Glu Asn Glu Ser 
225                 230                 235                 240 


Val Lys Ile Ala Phe Ala Val Thr Leu Glu Thr Val Leu Ala Gly His 
                245                 250                 255     


Glu Asn Trp Val Asn Ala Val His Trp Gln Pro Val Phe Tyr Lys Asp 
            260                 265                 270         


Gly Val Leu Gln Gln Pro Val Arg Leu Leu Ser Ala Ser Met Asp Lys 
        275                 280                 285             


Thr Met Ile Leu Trp Ala Pro Asp Glu Glu Ser Gly Val Trp Leu Glu 
    290                 295                 300                 


Gln Val Arg Val Gly Glu Val Gly Gly Asn Thr Leu Gly Phe Tyr Asp 
305                 310                 315                 320 


Cys Gln Phe Asn Glu Asp Gly Ser Met Ile Ile Ala His Ala Phe His 
                325                 330                 335     


Gly Ala Leu His Leu Trp Lys Gln Asn Thr Val Asn Pro Arg Glu Trp 
            340                 345                 350         


Thr Pro Glu Ile Val Ile Ser Gly His Phe Asp Gly Val Gln Asp Leu 
        355                 360                 365             


Val Trp Asp Pro Glu Gly Glu Phe Ile Ile Thr Val Gly Thr Asp Gln 
    370                 375                 380                 


Thr Thr Arg Leu Phe Ala Pro Trp Lys Arg Lys Asp Gln Ser Gln Val 
385                 390                 395                 400 


Thr Trp His Glu Ile Ala Arg Pro Gln Ile His Gly Tyr Asp Leu Lys 
                405                 410                 415     


Cys Leu Ala Met Ile Asn Arg Phe Gln Phe Val Ser Gly Ala Asp Glu 
            420                 425                 430         


Lys Val Leu Arg Val Phe Ser Ala Pro Arg Asn Phe Val Glu Asn Phe 
        435                 440                 445             


Cys Ala Ile Thr Gly Gln Ser Leu Asn His Val Leu Cys Asn Gln Asp 
    450                 455                 460                 


Ser Asp Leu Pro Glu Gly Ala Thr Val Pro Ala Leu Gly Leu Ser Asn 
465                 470                 475                 480 


Lys Ala Val Phe Gln Gly Asp Ile Ala Ser Gln Pro Ser Asp Glu Glu 
                485                 490                 495     


Glu Leu Leu Thr Ser Thr Gly Phe Glu Tyr Gln Gln Val Ala Phe Gln 
            500                 505                 510         


Pro Ser Ile Leu Thr Glu Pro Pro Thr Glu Asp His Leu Leu Gln Asn 
        515                 520                 525             


Thr Leu Trp Pro Glu Val Gln Lys Leu Tyr Gly His Gly Tyr Glu Ile 
    530                 535                 540                 


Phe Cys Val Thr Cys Asn Ser Ser Lys Thr Leu Leu Ala Ser Ala Cys 
545                 550                 555                 560 


Lys Ala Ala Lys Lys Glu His Ala Ala Ile Ile Leu Trp Asn Thr Thr 
                565                 570                 575     


Ser Trp Lys Gln Val Gln Asn Leu Val Phe His Ser Leu Thr Val Thr 
            580                 585                 590         


Gln Met Ala Phe Ser Pro Asn Glu Lys Phe Leu Leu Ala Val Ser Arg 
        595                 600                 605             


Asp Arg Thr Trp Ser Leu Trp Lys Lys Gln Asp Thr Ile Ser Pro Glu 
    610                 615                 620                 


Phe Glu Pro Val Phe Ser Leu Phe Ala Phe Thr Asn Lys Ile Thr Ser 
625                 630                 635                 640 


Val His Ser Arg Ile Ile Trp Ser Cys Asp Trp Ser Pro Asp Ser Lys 
                645                 650                 655     


Tyr Phe Phe Thr Gly Ser Arg Asp Lys Lys Val Val Val Trp Gly Glu 
            660                 665                 670         


Cys Asp Ser Thr Asp Asp Cys Ile Glu His Asn Ile Gly Pro Cys Ser 
        675                 680                 685             


Ser Val Leu Asp Val Gly Gly Ala Val Thr Ala Val Ser Val Cys Pro 
    690                 695                 700                 


Val Leu His Pro Ser Gln Arg Tyr Val Val Ala Val Gly Leu Glu Cys 
705                 710                 715                 720 


Gly Lys Ile Cys Leu Tyr Thr Trp Lys Lys Thr Asp Gln Val Pro Glu 
                725                 730                 735     


Ile Asn Asp Trp Thr His Cys Val Glu Thr Ser Gln Ser Gln Ser His 
            740                 745                 750         


Thr Leu Ala Ile Arg Lys Leu Cys Trp Lys Asn Cys Ser Gly Lys Thr 
        755                 760                 765             


Glu Gln Lys Glu Ala Glu Gly Ala Glu Trp Leu His Phe Ala Ser Cys 
    770                 775                 780                 


Gly Glu Asp His Thr Val Lys Ile His Arg Val Asn Lys Cys Ala Leu 
785                 790                 795                 800 


<210>  4705
<211>  756
<212>  PRT
<213>  Homo Sapiens

<400>  4705

Met Val Ala Pro Val Leu Glu Thr Ser His Val Phe Cys Cys Pro Asn 
1               5                   10                  15      


Arg Val Arg Gly Val Leu Asn Trp Ser Ser Gly Pro Arg Gly Leu Leu 
            20                  25                  30          


Ala Phe Gly Thr Ser Cys Ser Val Val Leu Tyr Asp Pro Leu Lys Arg 
        35                  40                  45              


Val Val Val Thr Asn Leu Asn Gly His Thr Ala Arg Val Asn Cys Ile 
    50                  55                  60                  


Gln Trp Ile Cys Lys Gln Asp Gly Ser Pro Ser Thr Glu Leu Val Ser 
65                  70                  75                  80  


Gly Gly Ser Asp Asn Gln Val Ile His Trp Glu Ile Glu Asp Asn Gln 
                85                  90                  95      


Leu Leu Lys Ala Val His Leu Gln Gly His Glu Gly Pro Val Tyr Ala 
            100                 105                 110         


Val His Ala Val Tyr Gln Arg Arg Thr Ser Asp Pro Ala Leu Cys Thr 
        115                 120                 125             


Leu Ile Val Ser Ala Ala Ala Asp Ser Ala Val Arg Leu Trp Ser Lys 
    130                 135                 140                 


Lys Gly Pro Glu Val Pro Ile Leu Ala Cys Gly Asn Asp Asp Cys Arg 
145                 150                 155                 160 


Ile His Ile Phe Ala Gln Gln Asn Asp Gln Phe Gln Lys Val Leu Ser 
                165                 170                 175     


Leu Cys Gly His Glu Asp Trp Ile Arg Gly Val Glu Trp Ala Ala Phe 
            180                 185                 190         


Gly Arg Asp Leu Phe Leu Ala Ser Cys Ser Gln Asp Cys Leu Ile Arg 
        195                 200                 205             


Ile Trp Lys Leu Tyr Ile Lys Ser Thr Ser Leu Glu Thr Gln Asp Asp 
    210                 215                 220                 


Asp Asn Ile Arg Leu Lys Glu Asn Thr Phe Thr Ile Glu Asn Glu Ser 
225                 230                 235                 240 


Val Lys Ile Ala Phe Ala Val Thr Leu Glu Thr Val Leu Ala Gly His 
                245                 250                 255     


Glu Asn Trp Val Asn Ala Val His Trp Gln Pro Val Phe Tyr Lys Asp 
            260                 265                 270         


Gly Val Leu Gln Gln Pro Val Arg Leu Leu Ser Ala Ser Met Asp Lys 
        275                 280                 285             


Thr Met Ile Leu Trp Ala Pro Asp Glu Glu Ser Gly Val Trp Leu Glu 
    290                 295                 300                 


Gln Arg Glu Trp Thr Pro Glu Ile Val Ile Ser Gly His Phe Asp Gly 
305                 310                 315                 320 


Val Gln Asp Leu Val Trp Asp Pro Glu Gly Glu Phe Ile Ile Thr Val 
                325                 330                 335     


Gly Thr Asp Gln Thr Thr Arg Leu Phe Ala Pro Trp Lys Arg Lys Asp 
            340                 345                 350         


Gln Ser Gln Val Thr Trp His Glu Ile Ala Arg Pro Gln Ile His Gly 
        355                 360                 365             


Tyr Asp Leu Lys Cys Leu Ala Met Ile Asn Arg Phe Gln Phe Val Ser 
    370                 375                 380                 


Gly Ala Asp Glu Lys Val Leu Arg Val Phe Ser Ala Pro Arg Asn Phe 
385                 390                 395                 400 


Val Glu Asn Phe Cys Ala Ile Thr Gly Gln Ser Leu Asn His Val Leu 
                405                 410                 415     


Cys Asn Gln Asp Ser Asp Leu Pro Glu Gly Ala Thr Val Pro Ala Leu 
            420                 425                 430         


Gly Leu Ser Asn Lys Ala Val Phe Gln Gly Asp Ile Ala Ser Gln Pro 
        435                 440                 445             


Ser Asp Glu Glu Glu Leu Leu Thr Ser Thr Gly Phe Glu Tyr Gln Gln 
    450                 455                 460                 


Val Ala Phe Gln Pro Ser Ile Leu Thr Glu Pro Pro Thr Glu Asp His 
465                 470                 475                 480 


Leu Leu Gln Asn Thr Leu Trp Pro Glu Val Gln Lys Leu Tyr Gly His 
                485                 490                 495     


Gly Tyr Glu Ile Phe Cys Val Thr Cys Asn Ser Ser Lys Thr Leu Leu 
            500                 505                 510         


Ala Ser Ala Cys Lys Ala Ala Lys Lys Glu His Ala Ala Ile Ile Leu 
        515                 520                 525             


Trp Asn Thr Thr Ser Trp Lys Gln Val Gln Asn Leu Val Phe His Ser 
    530                 535                 540                 


Leu Thr Val Thr Gln Met Ala Phe Ser Pro Asn Glu Lys Phe Leu Leu 
545                 550                 555                 560 


Ala Val Ser Arg Asp Arg Thr Trp Ser Leu Trp Lys Lys Gln Asp Thr 
                565                 570                 575     


Ile Ser Pro Glu Phe Glu Pro Val Phe Ser Leu Phe Ala Phe Thr Asn 
            580                 585                 590         


Lys Ile Thr Ser Val His Ser Arg Ile Ile Trp Ser Cys Asp Trp Ser 
        595                 600                 605             


Pro Asp Ser Lys Tyr Phe Phe Thr Gly Ser Arg Asp Lys Lys Val Val 
    610                 615                 620                 


Val Trp Gly Glu Cys Asp Ser Thr Asp Asp Cys Ile Glu His Asn Ile 
625                 630                 635                 640 


Gly Pro Cys Ser Ser Val Leu Asp Val Gly Gly Ala Val Thr Ala Val 
                645                 650                 655     


Ser Val Cys Pro Val Leu His Pro Ser Gln Arg Tyr Val Val Ala Val 
            660                 665                 670         


Gly Leu Glu Cys Gly Lys Ile Cys Leu Tyr Thr Trp Lys Lys Thr Asp 
        675                 680                 685             


Gln Val Pro Glu Ile Asn Asp Trp Thr His Cys Val Glu Thr Ser Gln 
    690                 695                 700                 


Ser Gln Ser His Thr Leu Ala Ile Arg Lys Leu Cys Trp Lys Asn Cys 
705                 710                 715                 720 


Ser Gly Lys Thr Glu Gln Lys Glu Ala Glu Gly Ala Glu Trp Leu His 
                725                 730                 735     


Phe Ala Ser Cys Gly Glu Asp His Thr Val Lys Ile His Arg Val Asn 
            740                 745                 750         


Lys Cys Ala Leu 
        755     


<210>  4706
<211>  821
<212>  PRT
<213>  Homo Sapiens

<400>  4706

Met Val Ala Pro Val Leu Glu Thr Ser His Val Phe Cys Cys Pro Asn 
1               5                   10                  15      


Arg Val Arg Gly Val Leu Asn Trp Ser Ser Gly Pro Arg Gly Leu Leu 
            20                  25                  30          


Ala Phe Gly Thr Ser Cys Ser Val Val Leu Tyr Asp Pro Leu Lys Arg 
        35                  40                  45              


Val Val Val Thr Asn Leu Asn Gly His Thr Ala Arg Val Asn Cys Ile 
    50                  55                  60                  


Gln Trp Ile Cys Lys Gln Asp Gly Ser Pro Ser Thr Glu Leu Val Ser 
65                  70                  75                  80  


Gly Gly Ser Asp Asn Gln Val Ile His Trp Glu Ile Glu Asp Asn Gln 
                85                  90                  95      


Leu Leu Lys Ala Val His Leu Gln Gly His Glu Gly Pro Val Tyr Ala 
            100                 105                 110         


Val His Ala Val Tyr Gln Arg Arg Thr Ser Asp Pro Ala Leu Cys Thr 
        115                 120                 125             


Leu Ile Val Ser Ala Ala Ala Asp Ser Ala Val Arg Leu Trp Ser Lys 
    130                 135                 140                 


Lys Gly Pro Glu Val Thr Trp Lys Thr Gly Gln Val Glu Arg Gly Arg 
145                 150                 155                 160 


Ala Trp Lys Pro Pro Ala Ser Leu Ala Leu Cys Ser Arg Ser Cys Asp 
                165                 170                 175     


Ser Met Val Ser Cys Tyr Ala Ser Ile Leu Cys Lys Ala Leu Trp Lys 
            180                 185                 190         


Glu Lys Leu His Thr Phe Trp His His Asn Arg Ile Ser Phe Leu Pro 
        195                 200                 205             


Ser Ala Phe Arg Pro Ile Pro Ile Leu Ala Cys Gly Asn Asp Asp Cys 
    210                 215                 220                 


Arg Ile His Ile Phe Ala Gln Gln Asn Asp Gln Phe Gln Lys Val Leu 
225                 230                 235                 240 


Ser Leu Cys Gly His Glu Asp Trp Ile Arg Gly Val Glu Trp Ala Ala 
                245                 250                 255     


Phe Gly Arg Asp Leu Phe Leu Ala Ser Cys Ser Gln Asp Cys Leu Ile 
            260                 265                 270         


Arg Ile Trp Lys Leu Tyr Ile Lys Ser Thr Ser Leu Glu Thr Gln Asp 
        275                 280                 285             


Asp Asp Asn Ile Arg Leu Lys Glu Asn Thr Phe Thr Ile Glu Asn Glu 
    290                 295                 300                 


Ser Val Lys Ile Ala Phe Ala Val Thr Leu Glu Thr Val Leu Ala Gly 
305                 310                 315                 320 


His Glu Asn Trp Val Asn Ala Val His Trp Gln Pro Val Phe Tyr Lys 
                325                 330                 335     


Asp Gly Val Leu Gln Gln Pro Val Arg Leu Leu Ser Ala Ser Met Asp 
            340                 345                 350         


Lys Thr Met Ile Leu Trp Ala Pro Asp Glu Glu Ser Gly Val Trp Leu 
        355                 360                 365             


Glu Gln Arg Glu Trp Thr Pro Glu Ile Val Ile Ser Gly His Phe Asp 
    370                 375                 380                 


Gly Val Gln Asp Leu Val Trp Asp Pro Glu Gly Glu Phe Ile Ile Thr 
385                 390                 395                 400 


Val Gly Thr Asp Gln Thr Thr Arg Leu Phe Ala Pro Trp Lys Arg Lys 
                405                 410                 415     


Asp Gln Ser Gln Val Thr Trp His Glu Ile Ala Arg Pro Gln Ile His 
            420                 425                 430         


Gly Tyr Asp Leu Lys Cys Leu Ala Met Ile Asn Arg Phe Gln Phe Val 
        435                 440                 445             


Ser Gly Ala Asp Glu Lys Val Leu Arg Val Phe Ser Ala Pro Arg Asn 
    450                 455                 460                 


Phe Val Glu Asn Phe Cys Ala Ile Thr Gly Gln Ser Leu Asn His Val 
465                 470                 475                 480 


Leu Cys Asn Gln Asp Ser Asp Leu Pro Glu Gly Ala Thr Val Pro Ala 
                485                 490                 495     


Leu Gly Leu Ser Asn Lys Ala Val Phe Gln Gly Asp Ile Ala Ser Gln 
            500                 505                 510         


Pro Ser Asp Glu Glu Glu Leu Leu Thr Ser Thr Gly Phe Glu Tyr Gln 
        515                 520                 525             


Gln Val Ala Phe Gln Pro Ser Ile Leu Thr Glu Pro Pro Thr Glu Asp 
    530                 535                 540                 


His Leu Leu Gln Asn Thr Leu Trp Pro Glu Val Gln Lys Leu Tyr Gly 
545                 550                 555                 560 


His Gly Tyr Glu Ile Phe Cys Val Thr Cys Asn Ser Ser Lys Thr Leu 
                565                 570                 575     


Leu Ala Ser Ala Cys Lys Ala Ala Lys Lys Glu His Ala Ala Ile Ile 
            580                 585                 590         


Leu Trp Asn Thr Thr Ser Trp Lys Gln Val Gln Asn Leu Val Phe His 
        595                 600                 605             


Ser Leu Thr Val Thr Gln Met Ala Phe Ser Pro Asn Glu Lys Phe Leu 
    610                 615                 620                 


Leu Ala Val Ser Arg Asp Arg Thr Trp Ser Leu Trp Lys Lys Gln Asp 
625                 630                 635                 640 


Thr Ile Ser Pro Glu Phe Glu Pro Val Phe Ser Leu Phe Ala Phe Thr 
                645                 650                 655     


Asn Lys Ile Thr Ser Val His Ser Arg Ile Ile Trp Ser Cys Asp Trp 
            660                 665                 670         


Ser Pro Asp Ser Lys Tyr Phe Phe Thr Gly Ser Arg Asp Lys Lys Val 
        675                 680                 685             


Val Val Trp Gly Glu Cys Asp Ser Thr Asp Asp Cys Ile Glu His Asn 
    690                 695                 700                 


Ile Gly Pro Cys Ser Ser Val Leu Asp Val Gly Gly Ala Val Thr Ala 
705                 710                 715                 720 


Val Ser Val Cys Pro Val Leu His Pro Ser Gln Arg Tyr Val Val Ala 
                725                 730                 735     


Val Gly Leu Glu Cys Gly Lys Ile Cys Leu Tyr Thr Trp Lys Lys Thr 
            740                 745                 750         


Asp Gln Val Pro Glu Ile Asn Asp Trp Thr His Cys Val Glu Thr Ser 
        755                 760                 765             


Gln Ser Gln Ser His Thr Leu Ala Ile Arg Lys Leu Cys Trp Lys Asn 
    770                 775                 780                 


Cys Ser Gly Lys Thr Glu Gln Lys Glu Ala Glu Gly Ala Glu Trp Leu 
785                 790                 795                 800 


His Phe Ala Ser Cys Gly Glu Asp His Thr Val Lys Ile His Arg Val 
                805                 810                 815     


Asn Lys Cys Ala Leu 
            820     


<210>  4707
<211>  51
<212>  PRT
<213>  Homo Sapiens

<400>  4707

Met Val Ala Pro Val Leu Glu Thr Ser His Val Phe Cys Cys Pro Asn 
1               5                   10                  15      


Arg Val Arg Gly Val Leu Asn Trp Ser Ser Gly Pro Arg Gly Leu Leu 
            20                  25                  30          


Ala Phe Gly Thr Ser Cys Ser Val Val Leu Tyr Asp Pro Leu Pro Leu 
        35                  40                  45              


Leu Leu Asn 
    50      


<210>  4708
<211>  51
<212>  PRT
<213>  Homo Sapiens

<400>  4708

Met Val Ala Pro Val Leu Glu Thr Ser His Val Phe Cys Cys Pro Asn 
1               5                   10                  15      


Arg Val Arg Gly Val Leu Asn Trp Ser Ser Gly Pro Arg Gly Leu Leu 
            20                  25                  30          


Ala Phe Gly Thr Ser Cys Ser Val Val Leu Tyr Asp Pro Leu Pro Leu 
        35                  40                  45              


Leu Leu Asn 
    50      


<210>  4709
<211>  150
<212>  PRT
<213>  Homo Sapiens

<400>  4709

Met Thr Arg Trp Ser Ser Tyr Leu Leu Gly Trp Thr Thr Phe Leu Leu 
1               5                   10                  15      


Tyr Ser Tyr Glu Ser Ser Gly Asp Tyr Pro Arg Cys Ile Phe Pro Phe 
            20                  25                  30          


Ile Tyr Arg Gly Lys Ala Tyr Asn Ser Cys Ile Ser Gln Gly Ser Phe 
        35                  40                  45              


Leu Gly Ser Leu Trp Cys Ser Val Thr Ser Val Phe Asp Glu Lys Gln 
    50                  55                  60                  


Gln Trp Lys Phe Cys Glu Thr Asn Glu Tyr Gly Gly Asn Ser Leu Arg 
65                  70                  75                  80  


Lys Pro Cys Ile Phe Pro Ser Ile Tyr Arg Asn Asn Val Val Ser Asp 
                85                  90                  95      


Cys Met Glu Asp Glu Ser Asn Lys Leu Trp Cys Pro Thr Thr Glu Asn 
            100                 105                 110         


Met Asp Lys Asp Gly Lys Trp Ser Phe Cys Ala Asp Thr Arg Ile Ser 
        115                 120                 125             


Ala Leu Val Pro Gly Phe Pro Cys His Phe Pro Phe Asn Tyr Lys Asn 
    130                 135                 140                 


Lys Asn Tyr Phe Asn Cys 
145                 150 


<210>  4710
<211>  75
<212>  PRT
<213>  Homo Sapiens

<400>  4710

Met Thr Arg Trp Ser Ser Tyr Leu Leu Gly Trp Thr Thr Phe Leu Leu 
1               5                   10                  15      


Tyr Ser Tyr Glu Ser Ser Gly Gly Ile Ser Ala Leu Val Pro Gly Phe 
            20                  25                  30          


Pro Cys His Phe Pro Phe Asn Tyr Lys Asn Lys Asn Tyr Phe Asn Cys 
        35                  40                  45              


Thr Asn Glu Gly Ser Lys Glu Asn Leu Val Trp Cys Ala Thr Ser Tyr 
    50                  55                  60                  


Asn Tyr Asp Gln Asp His Thr Trp Val Tyr Cys 
65                  70                  75  


<210>  4711
<211>  223
<212>  PRT
<213>  Homo Sapiens

<400>  4711

Met Thr Arg Trp Ser Ser Tyr Leu Leu Gly Trp Thr Thr Phe Leu Leu 
1               5                   10                  15      


Tyr Ser Tyr Glu Ser Ser Gly Gly Met His Glu Glu Cys Val Phe Pro 
            20                  25                  30          


Phe Thr Tyr Lys Gly Ser Val Tyr Phe Thr Cys Thr His Ile His Ser 
        35                  40                  45              


Leu Ser Pro Trp Cys Ala Thr Arg Ala Val Tyr Asn Gly Gln Trp Lys 
    50                  55                  60                  


Tyr Cys Gln Ser Glu Asp Tyr Pro Arg Cys Ile Phe Pro Phe Ile Tyr 
65                  70                  75                  80  


Arg Gly Lys Ala Tyr Asn Ser Cys Ile Ser Gln Gly Ser Phe Leu Gly 
                85                  90                  95      


Ser Leu Trp Cys Ser Val Thr Ser Val Phe Asp Glu Lys Gln Gln Trp 
            100                 105                 110         


Lys Phe Cys Glu Thr Asn Glu Tyr Gly Gly Asn Ser Leu Arg Lys Pro 
        115                 120                 125             


Cys Ile Phe Pro Ser Ile Tyr Arg Asn Asn Val Val Ser Asp Cys Met 
    130                 135                 140                 


Glu Asp Glu Ser Asn Lys Leu Trp Cys Pro Thr Thr Glu Asn Met Asp 
145                 150                 155                 160 


Lys Asp Gly Lys Trp Ser Phe Cys Ala Asp Thr Arg Ile Ser Ala Leu 
                165                 170                 175     


Val Pro Gly Phe Pro Cys His Phe Pro Phe Asn Tyr Lys Asn Lys Asn 
            180                 185                 190         


Tyr Phe Asn Cys Thr Asn Glu Gly Ser Lys Glu Asn Leu Val Trp Cys 
        195                 200                 205             


Ala Thr Ser Tyr Asn Tyr Asp Gln Asp His Thr Trp Val Tyr Cys 
    210                 215                 220             


<210>  4712
<211>  220
<212>  PRT
<213>  Homo Sapiens

<400>  4712

Met Val Gln Leu Pro Val Gly Trp Thr Thr Phe Leu Leu Tyr Ser Tyr 
1               5                   10                  15      


Glu Ser Ser Gly Gly Met His Glu Glu Cys Val Phe Pro Phe Thr Tyr 
            20                  25                  30          


Lys Gly Ser Val Tyr Phe Thr Cys Thr His Ile His Ser Leu Ser Pro 
        35                  40                  45              


Trp Cys Ala Thr Arg Ala Val Tyr Asn Gly Gln Trp Lys Tyr Cys Gln 
    50                  55                  60                  


Ser Glu Asp Tyr Pro Arg Cys Ile Phe Pro Phe Ile Tyr Arg Gly Lys 
65                  70                  75                  80  


Ala Tyr Asn Ser Cys Ile Ser Gln Gly Ser Phe Leu Gly Ser Leu Trp 
                85                  90                  95      


Cys Ser Val Thr Ser Val Phe Asp Glu Lys Gln Gln Trp Lys Phe Cys 
            100                 105                 110         


Glu Thr Asn Glu Tyr Gly Gly Asn Ser Leu Arg Lys Pro Cys Ile Phe 
        115                 120                 125             


Pro Ser Ile Tyr Arg Asn Asn Val Val Ser Asp Cys Met Glu Asp Glu 
    130                 135                 140                 


Ser Asn Lys Leu Trp Cys Pro Thr Thr Glu Asn Met Asp Lys Asp Gly 
145                 150                 155                 160 


Lys Trp Ser Phe Cys Ala Asp Thr Arg Ile Ser Ala Leu Val Pro Gly 
                165                 170                 175     


Phe Pro Cys His Phe Pro Phe Asn Tyr Lys Asn Lys Asn Tyr Phe Asn 
            180                 185                 190         


Cys Thr Asn Glu Gly Ser Lys Glu Asn Leu Val Trp Cys Ala Thr Ser 
        195                 200                 205             


Tyr Asn Tyr Asp Gln Asp His Thr Trp Val Tyr Cys 
    210                 215                 220 


<210>  4713
<211>  76
<212>  PRT
<213>  Homo Sapiens

<400>  4713

Ser Asn Lys Leu Trp Cys Pro Thr Thr Glu Asn Met Asp Lys Asp Gly 
1               5                   10                  15      


Lys Trp Ser Phe Cys Ala Asp Thr Arg Ile Ser Ala Leu Val Pro Gly 
            20                  25                  30          


Phe Pro Cys His Phe Pro Phe Asn Tyr Lys Asn Lys Asn Tyr Phe Asn 
        35                  40                  45              


Cys Thr Asn Glu Gly Ser Lys Glu Asn Leu Val Trp Cys Ala Thr Ser 
    50                  55                  60                  


Tyr Asn Tyr Asp Gln Asp His Thr Trp Val Tyr Cys 
65                  70                  75      


<210>  4714
<211>  154
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4714

Xaa Tyr Pro Arg Cys Ile Phe Pro Phe Ile Tyr Arg Gly Lys Ala Tyr 
1               5                   10                  15      


Asn Ser Cys Ile Ser Gln Gly Ser Phe Leu Gly Ser Leu Trp Cys Ser 
            20                  25                  30          


Val Thr Ser Val Phe Asp Glu Lys Gln Gln Trp Lys Phe Cys Glu Thr 
        35                  40                  45              


Asn Glu Tyr Gly Gly Asn Ser Leu Arg Lys Pro Cys Ile Phe Pro Ser 
    50                  55                  60                  


Ile Tyr Arg Asn Asn Val Val Ser Asp Cys Met Glu Asp Glu Ser Asn 
65                  70                  75                  80  


Lys Leu Trp Cys Pro Thr Thr Glu Asn Met Asp Lys Asp Gly Lys Trp 
                85                  90                  95      


Ser Phe Cys Ala Asp Thr Arg Ile Ser Ala Leu Val Pro Gly Phe Pro 
            100                 105                 110         


Cys His Phe Pro Phe Asn Tyr Lys Asn Lys Asn Tyr Phe Asn Cys Thr 
        115                 120                 125             


Asn Glu Gly Ser Lys Glu Asn Leu Val Trp Cys Ala Thr Ser Tyr Asn 
    130                 135                 140                 


Tyr Asp Gln Asp His Thr Trp Val Tyr Cys 
145                 150                 


<210>  4715
<211>  178
<212>  PRT
<213>  Homo Sapiens

<400>  4715

Phe Ile Gly Ile Phe Leu Ile Asp Gly Val Thr Gly Arg Ile Ile His 
1               5                   10                  15      


Ser Ser Val Gln Lys Lys Ala Lys Gly Pro Val His Ile Val His Ser 
            20                  25                  30          


Glu Asn Trp Val Val Tyr Gln Tyr Trp Asn Thr Lys Ala Arg Arg Asn 
        35                  40                  45              


Glu Phe Thr Val Leu Glu Leu Tyr Glu Gly Thr Glu Gln Tyr Asn Ala 
    50                  55                  60                  


Thr Ala Phe Ser Ser Leu Asp Arg Pro Gln Leu Pro Gln Val Leu Gln 
65                  70                  75                  80  


Gln Ser Tyr Ile Phe Pro Ser Ser Ile Ser Ala Met Glu Ala Thr Ile 
                85                  90                  95      


Thr Glu Arg Gly Ile Thr Ser Arg His Leu Leu Ser Phe Ala Gly Ser 
            100                 105                 110         


Pro Pro Pro Arg Asp Pro Asn Arg Thr Lys Gln Met Tyr Arg Tyr Thr 
        115                 120                 125             


Gln Ser Asp Ser Ser Thr Ile Thr Arg Gln Phe Leu Glu Cys Glu Val 
    130                 135                 140                 


Ser Thr Gln Leu Pro Arg Val Trp Ser Pro Leu Val Trp Leu Trp Pro 
145                 150                 155                 160 


Met Val Trp Thr Phe Thr Lys Leu Glu Ser Thr His Pro Ser Ser Leu 
                165                 170                 175     


Thr Phe 
        


<210>  4716
<211>  75
<212>  PRT
<213>  Homo Sapiens

<400>  4716

Met Ala Ala Glu Trp Ala Ser Arg Phe Trp Leu Trp Ala Thr Leu Leu 
1               5                   10                  15      


Ile Pro Ala Ala Ala Val Tyr Glu Asp Gln Val Gly Lys Phe Asp Trp 
            20                  25                  30          


Arg Gln Gln Tyr Val Gly Lys Val Lys Phe Ala Ser Leu Glu Phe Ser 
        35                  40                  45              


Pro Gly Ser Lys Lys Leu Val Val Ala Thr Glu Lys Asn Val Ile Ala 
    50                  55                  60                  


Ala Leu Asn Ser Arg Thr Gly Glu Ile Cys Glu 
65                  70                  75  


<210>  4717
<211>  992
<212>  PRT
<213>  Homo Sapiens

<400>  4717

Met Ala Ala Glu Trp Ala Ser Arg Phe Trp Leu Trp Ala Thr Leu Leu 
1               5                   10                  15      


Ile Pro Ala Ala Ala Val Tyr Glu Asp Gln Val Gly Lys Phe Asp Trp 
            20                  25                  30          


Arg Gln Gln Tyr Val Gly Lys Val Lys Phe Ala Ser Leu Glu Phe Ser 
        35                  40                  45              


Pro Gly Ser Lys Lys Leu Val Val Ala Thr Glu Lys Asn Val Ile Ala 
    50                  55                  60                  


Ala Leu Asn Ser Arg Thr Gly Glu Ile Leu Trp Arg His Val Asp Lys 
65                  70                  75                  80  


Gly Thr Ala Glu Gly Ala Val Asp Ala Met Leu Leu His Gly Gln Asp 
                85                  90                  95      


Val Ile Thr Val Ser Asn Gly Gly Arg Ile Met Arg Ser Trp Glu Thr 
            100                 105                 110         


Asn Ile Gly Gly Leu Asn Trp Glu Ile Thr Leu Asp Ser Gly Ser Phe 
        115                 120                 125             


Gln Ala Leu Gly Leu Val Gly Leu Gln Glu Ser Val Arg Tyr Ile Ala 
    130                 135                 140                 


Val Leu Lys Lys Thr Thr Leu Ala Leu His His Leu Ser Ser Gly His 
145                 150                 155                 160 


Leu Lys Trp Val Glu His Leu Pro Glu Ser Asp Ser Ile His Tyr Gln 
                165                 170                 175     


Met Val Tyr Ser Tyr Gly Ser Gly Val Val Trp Ala Leu Gly Val Val 
            180                 185                 190         


Pro Phe Ser His Val Asn Ile Val Lys Phe Asn Val Glu Asp Gly Glu 
        195                 200                 205             


Ile Val Gln Gln Val Arg Val Ser Thr Pro Trp Leu Gln His Leu Ser 
    210                 215                 220                 


Gly Ala Cys Gly Val Val Asp Glu Ala Val Leu Val Cys Pro Asp Pro 
225                 230                 235                 240 


Ser Ser Arg Ser Leu Gln Thr Leu Ala Leu Glu Thr Glu Trp Glu Leu 
                245                 250                 255     


Arg Gln Ile Pro Leu Gln Ser Leu Asp Leu Glu Phe Gly Ser Gly Phe 
            260                 265                 270         


Gln Pro Arg Val Leu Pro Thr Gln Pro Asn Pro Val Asp Ala Ser Arg 
        275                 280                 285             


Ala Gln Phe Phe Leu His Leu Ser Pro Ser His Tyr Ala Leu Leu Gln 
    290                 295                 300                 


Tyr His Tyr Gly Thr Leu Ser Leu Leu Lys Asn Phe Pro Gln Thr Ala 
305                 310                 315                 320 


Leu Val Ser Phe Ala Thr Thr Gly Glu Lys Thr Val Ala Ala Val Met 
                325                 330                 335     


Ala Cys Arg Asn Glu Val Lys Ser Ser Ser Ser Glu Asp Gly Ser Met 
            340                 345                 350         


Gly Ser Phe Ser Glu Lys Ser Ser Ser Lys Asp Ser Leu Ala Cys Phe 
        355                 360                 365             


Asn Gln Thr Tyr Thr Ile Asn Leu Tyr Leu Val Glu Thr Gly Arg Arg 
    370                 375                 380                 


Leu Leu Asp Thr Thr Ile Thr Phe Ser Leu Glu Gln Ser Gly Thr Arg 
385                 390                 395                 400 


Pro Glu Arg Leu Tyr Ile Gln Val Phe Leu Lys Lys Asp Asp Ser Val 
                405                 410                 415     


Gly Tyr Arg Ala Leu Val Gln Thr Glu Asp His Leu Leu Leu Phe Leu 
            420                 425                 430         


Gln Gln Leu Ala Gly Lys Val Val Leu Trp Ser Arg Glu Glu Ser Leu 
        435                 440                 445             


Ala Glu Val Val Cys Leu Glu Met Val Asp Leu Pro Leu Thr Gly Ala 
    450                 455                 460                 


Gln Ala Glu Leu Glu Gly Glu Phe Gly Lys Lys Ala Asp Gly Leu Leu 
465                 470                 475                 480 


Gly Met Phe Leu Lys Arg Leu Ser Ser Gln Leu Ile Leu Leu Gln Ala 
                485                 490                 495     


Trp Thr Ser His Leu Trp Lys Met Phe Tyr Asp Ala Arg Lys Pro Arg 
            500                 505                 510         


Ser Gln Ile Lys Asn Glu Ile Asn Ile Asp Thr Leu Ala Arg Asp Glu 
        515                 520                 525             


Phe Asn Leu Gln Lys Met Met Val Met Val Thr Ala Ser Gly Lys Leu 
    530                 535                 540                 


Phe Gly Ile Glu Ser Ser Ser Gly Thr Ile Leu Trp Lys Gln Tyr Leu 
545                 550                 555                 560 


Pro Asn Val Lys Pro Asp Ser Ser Phe Lys Leu Met Val Gln Arg Thr 
                565                 570                 575     


Thr Ala His Phe Pro His Pro Pro Gln Cys Thr Leu Leu Val Lys Asp 
            580                 585                 590         


Lys Glu Ser Gly Met Ser Ser Leu Tyr Val Phe Asn Pro Ile Phe Gly 
        595                 600                 605             


Lys Trp Ser Gln Val Ala Pro Pro Val Leu Lys Arg Pro Ile Leu Gln 
    610                 615                 620                 


Ser Leu Leu Leu Pro Val Met Asp Gln Asp Tyr Ala Lys Val Leu Leu 
625                 630                 635                 640 


Leu Ile Asp Asp Glu Tyr Lys Val Thr Ala Phe Pro Ala Thr Arg Asn 
                645                 650                 655     


Val Leu Arg Gln Leu His Glu Leu Ala Pro Ser Ile Phe Phe Tyr Leu 
            660                 665                 670         


Val Asp Ala Glu Gln Gly Arg Leu Cys Gly Tyr Arg Leu Arg Lys Asp 
        675                 680                 685             


Leu Thr Thr Glu Leu Ser Trp Glu Leu Thr Ile Pro Pro Glu Val Gln 
    690                 695                 700                 


Arg Ile Val Lys Val Lys Gly Lys Arg Ser Ser Glu His Val His Ser 
705                 710                 715                 720 


Gln Gly Arg Val Met Gly Asp Arg Ser Val Leu Tyr Lys Ser Leu Asn 
                725                 730                 735     


Pro Asn Leu Leu Ala Val Val Thr Glu Ser Thr Asp Ala His His Glu 
            740                 745                 750         


Arg Thr Phe Ile Gly Ile Phe Leu Ile Asp Gly Val Thr Gly Arg Ile 
        755                 760                 765             


Ile His Ser Ser Val Gln Lys Lys Ala Lys Gly Pro Val His Ile Val 
    770                 775                 780                 


His Ser Glu Asn Trp Val Val Tyr Gln Tyr Trp Asn Thr Lys Ala Arg 
785                 790                 795                 800 


Arg Asn Glu Phe Thr Val Leu Glu Leu Tyr Glu Gly Thr Glu Gln Tyr 
                805                 810                 815     


Asn Ala Thr Ala Phe Ser Ser Leu Asp Arg Pro Gln Leu Pro Gln Val 
            820                 825                 830         


Leu Gln Gln Ser Tyr Ile Phe Pro Ser Ser Ile Ser Ala Met Glu Ala 
        835                 840                 845             


Thr Ile Thr Glu Arg Gly Ile Thr Ser Arg His Leu Leu Ile Gly Leu 
    850                 855                 860                 


Pro Ser Gly Ala Ile Leu Ser Leu Pro Lys Ala Leu Leu Asp Pro Arg 
865                 870                 875                 880 


Arg Pro Glu Ile Pro Thr Glu Gln Ser Arg Glu Glu Asn Leu Ile Pro 
                885                 890                 895     


Tyr Ser Pro Asp Val Gln Ile His Ala Glu Arg Phe Ile Asn Tyr Asn 
            900                 905                 910         


Gln Thr Val Ser Arg Met Arg Gly Ile Tyr Thr Ala Pro Ser Gly Leu 
        915                 920                 925             


Glu Ser Thr Cys Leu Val Val Ala Tyr Gly Leu Asp Ile Tyr Gln Thr 
    930                 935                 940                 


Arg Val Tyr Pro Ser Lys Gln Phe Asp Val Leu Lys Asp Asp Tyr Asp 
945                 950                 955                 960 


Tyr Val Leu Ile Ser Ser Val Leu Phe Gly Leu Val Phe Ala Thr Met 
                965                 970                 975     


Ile Thr Lys Arg Leu Ala Gln Val Lys Leu Leu Asn Arg Ala Trp Arg 
            980                 985                 990         


<210>  4718
<211>  993
<212>  PRT
<213>  Homo Sapiens

<400>  4718

Met Ala Ala Glu Trp Ala Ser Arg Phe Trp Leu Trp Ala Thr Leu Leu 
1               5                   10                  15      


Ile Pro Ala Ala Ala Val Tyr Glu Asp Gln Val Gly Lys Phe Asp Trp 
            20                  25                  30          


Arg Gln Gln Tyr Val Gly Lys Val Lys Phe Ala Ser Leu Glu Phe Ser 
        35                  40                  45              


Pro Gly Ser Lys Lys Leu Val Val Ala Thr Glu Lys Asn Val Ile Ala 
    50                  55                  60                  


Ala Leu Asn Ser Arg Thr Gly Glu Ile Leu Trp Arg His Val Asp Lys 
65                  70                  75                  80  


Gly Thr Ala Glu Gly Ala Val Asp Ala Met Leu Leu His Gly Gln Asp 
                85                  90                  95      


Val Ile Thr Val Ser Asn Gly Gly Arg Ile Met Arg Ser Trp Glu Thr 
            100                 105                 110         


Asn Ile Gly Gly Leu Asn Trp Glu Ile Thr Leu Asp Ser Gly Ser Phe 
        115                 120                 125             


Gln Ala Leu Gly Leu Val Gly Leu Gln Glu Ser Val Arg Tyr Ile Ala 
    130                 135                 140                 


Val Leu Lys Lys Thr Thr Leu Ala Leu His His Leu Ser Ser Gly His 
145                 150                 155                 160 


Leu Lys Trp Val Glu His Leu Pro Glu Ser Asp Ser Ile His Tyr Gln 
                165                 170                 175     


Met Val Tyr Ser Tyr Gly Ser Gly Val Val Trp Ala Leu Gly Val Val 
            180                 185                 190         


Pro Phe Ser His Val Asn Ile Val Lys Phe Asn Val Glu Asp Gly Glu 
        195                 200                 205             


Ile Val Gln Gln Val Arg Val Ser Thr Pro Trp Leu Gln His Leu Ser 
    210                 215                 220                 


Gly Ala Cys Gly Val Val Asp Glu Ala Val Leu Val Cys Pro Asp Pro 
225                 230                 235                 240 


Ser Ser Arg Ser Leu Gln Thr Leu Ala Leu Glu Thr Glu Trp Glu Leu 
                245                 250                 255     


Arg Gln Ile Pro Leu Gln Ser Leu Asp Leu Glu Phe Gly Ser Gly Phe 
            260                 265                 270         


Gln Pro Arg Val Leu Pro Thr Gln Pro Asn Pro Val Asp Ala Ser Arg 
        275                 280                 285             


Ala Gln Phe Phe Leu His Leu Ser Pro Ser His Tyr Ala Leu Leu Gln 
    290                 295                 300                 


Tyr His Tyr Gly Thr Leu Ser Leu Leu Lys Asn Phe Pro Gln Thr Ala 
305                 310                 315                 320 


Leu Val Ser Phe Ala Thr Thr Gly Glu Lys Thr Val Ala Ala Val Met 
                325                 330                 335     


Ala Cys Arg Asn Glu Val Gln Lys Ser Ser Ser Ser Glu Asp Gly Ser 
            340                 345                 350         


Met Gly Ser Phe Ser Glu Lys Ser Ser Ser Lys Asp Ser Leu Ala Cys 
        355                 360                 365             


Phe Asn Gln Thr Tyr Thr Ile Asn Leu Tyr Leu Val Glu Thr Gly Arg 
    370                 375                 380                 


Arg Leu Leu Asp Thr Thr Ile Thr Phe Ser Leu Glu Gln Ser Gly Thr 
385                 390                 395                 400 


Arg Pro Glu Arg Leu Tyr Ile Gln Val Phe Leu Lys Lys Asp Asp Ser 
                405                 410                 415     


Val Gly Tyr Arg Ala Leu Val Gln Thr Glu Asp His Leu Leu Leu Phe 
            420                 425                 430         


Leu Gln Gln Leu Ala Gly Lys Val Val Leu Trp Ser Arg Glu Glu Ser 
        435                 440                 445             


Leu Ala Glu Val Val Cys Leu Glu Met Val Asp Leu Pro Leu Thr Gly 
    450                 455                 460                 


Ala Gln Ala Glu Leu Glu Gly Glu Phe Gly Lys Lys Ala Asp Gly Leu 
465                 470                 475                 480 


Leu Gly Met Phe Leu Lys Arg Leu Ser Ser Gln Leu Ile Leu Leu Gln 
                485                 490                 495     


Ala Trp Thr Ser His Leu Trp Lys Met Phe Tyr Asp Ala Arg Lys Pro 
            500                 505                 510         


Arg Ser Gln Ile Lys Asn Glu Ile Asn Ile Asp Thr Leu Ala Arg Asp 
        515                 520                 525             


Glu Phe Asn Leu Gln Lys Met Met Val Met Val Thr Ala Ser Gly Lys 
    530                 535                 540                 


Leu Phe Gly Ile Glu Ser Ser Ser Gly Thr Ile Leu Trp Lys Gln Tyr 
545                 550                 555                 560 


Leu Pro Asn Val Lys Pro Asp Ser Ser Phe Lys Leu Met Val Gln Arg 
                565                 570                 575     


Thr Thr Ala His Phe Pro His Pro Pro Gln Cys Thr Leu Leu Val Lys 
            580                 585                 590         


Asp Lys Glu Ser Gly Met Ser Ser Leu Tyr Val Phe Asn Pro Ile Phe 
        595                 600                 605             


Gly Lys Trp Ser Gln Val Ala Pro Pro Val Leu Lys Arg Pro Ile Leu 
    610                 615                 620                 


Gln Ser Leu Leu Leu Pro Val Met Asp Gln Asp Tyr Ala Lys Val Leu 
625                 630                 635                 640 


Leu Leu Ile Asp Asp Glu Tyr Lys Val Thr Ala Phe Pro Ala Thr Arg 
                645                 650                 655     


Asn Val Leu Arg Gln Leu His Glu Leu Ala Pro Ser Ile Phe Phe Tyr 
            660                 665                 670         


Leu Val Asp Ala Glu Gln Gly Arg Leu Cys Gly Tyr Arg Leu Arg Lys 
        675                 680                 685             


Asp Leu Thr Thr Glu Leu Ser Trp Glu Leu Thr Ile Pro Pro Glu Val 
    690                 695                 700                 


Gln Arg Ile Val Lys Val Lys Gly Lys Arg Ser Ser Glu His Val His 
705                 710                 715                 720 


Ser Gln Gly Arg Val Met Gly Asp Arg Ser Val Leu Tyr Lys Ser Leu 
                725                 730                 735     


Asn Pro Asn Leu Leu Ala Val Val Thr Glu Ser Thr Asp Ala His His 
            740                 745                 750         


Glu Arg Thr Phe Ile Gly Ile Phe Leu Ile Asp Gly Val Thr Gly Arg 
        755                 760                 765             


Ile Ile His Ser Ser Val Gln Lys Lys Ala Lys Gly Pro Val His Ile 
    770                 775                 780                 


Val His Ser Glu Asn Trp Val Val Tyr Gln Tyr Trp Asn Thr Lys Ala 
785                 790                 795                 800 


Arg Arg Asn Glu Phe Thr Val Leu Glu Leu Tyr Glu Gly Thr Glu Gln 
                805                 810                 815     


Tyr Asn Ala Thr Ala Phe Ser Ser Leu Asp Arg Pro Gln Leu Pro Gln 
            820                 825                 830         


Val Leu Gln Gln Ser Tyr Ile Phe Pro Ser Ser Ile Ser Ala Met Glu 
        835                 840                 845             


Ala Thr Ile Thr Glu Arg Gly Ile Thr Ser Arg His Leu Leu Ile Gly 
    850                 855                 860                 


Leu Pro Ser Gly Ala Ile Leu Ser Leu Pro Lys Ala Leu Leu Asp Pro 
865                 870                 875                 880 


Arg Arg Pro Glu Ile Pro Thr Glu Gln Ser Arg Glu Glu Asn Leu Ile 
                885                 890                 895     


Pro Tyr Ser Pro Asp Val Gln Ile His Ala Glu Arg Phe Ile Asn Tyr 
            900                 905                 910         


Asn Gln Thr Val Ser Arg Met Arg Gly Ile Tyr Thr Ala Pro Ser Gly 
        915                 920                 925             


Leu Glu Ser Thr Cys Leu Val Val Ala Tyr Gly Leu Asp Ile Tyr Gln 
    930                 935                 940                 


Thr Arg Val Tyr Pro Ser Lys Gln Phe Asp Val Leu Lys Asp Asp Tyr 
945                 950                 955                 960 


Asp Tyr Val Leu Ile Ser Ser Val Leu Phe Gly Leu Val Phe Ala Thr 
                965                 970                 975     


Met Ile Thr Lys Arg Leu Ala Gln Val Lys Leu Leu Asn Arg Ala Trp 
            980                 985                 990         


Arg 
    


<210>  4719
<211>  971
<212>  PRT
<213>  Homo Sapiens

<400>  4719

Met Ala Ala Glu Trp Ala Ser Arg Phe Trp Leu Trp Ala Thr Leu Leu 
1               5                   10                  15      


Ile Pro Ala Ala Ala Val Tyr Glu Asp Gln Val Gly Lys Phe Asp Trp 
            20                  25                  30          


Arg Gln Gln Tyr Val Gly Lys Val Lys Phe Ala Ser Leu Glu Phe Ser 
        35                  40                  45              


Pro Gly Ser Lys Lys Leu Val Val Ala Thr Glu Lys Asn Val Ile Ala 
    50                  55                  60                  


Ala Leu Asn Ser Arg Thr Gly Glu Ile Tyr Val Ile Thr Val Ser Asn 
65                  70                  75                  80  


Gly Gly Arg Ile Met Arg Ser Trp Glu Thr Asn Ile Gly Gly Leu Asn 
                85                  90                  95      


Trp Glu Ile Thr Leu Asp Ser Gly Ser Phe Gln Ala Leu Gly Leu Val 
            100                 105                 110         


Gly Leu Gln Glu Ser Val Arg Tyr Ile Ala Val Leu Lys Lys Thr Thr 
        115                 120                 125             


Leu Ala Leu His His Leu Ser Ser Gly His Leu Lys Trp Val Glu His 
    130                 135                 140                 


Leu Pro Glu Ser Asp Ser Ile His Tyr Gln Met Val Tyr Ser Tyr Gly 
145                 150                 155                 160 


Ser Gly Val Val Trp Ala Leu Gly Val Val Pro Phe Ser His Val Asn 
                165                 170                 175     


Ile Val Lys Phe Asn Val Glu Asp Gly Glu Ile Val Gln Gln Val Arg 
            180                 185                 190         


Val Ser Thr Pro Trp Leu Gln His Leu Ser Gly Ala Cys Gly Val Val 
        195                 200                 205             


Asp Glu Ala Val Leu Val Cys Pro Asp Pro Ser Ser Arg Ser Leu Gln 
    210                 215                 220                 


Thr Leu Ala Leu Glu Thr Glu Trp Glu Leu Arg Gln Ile Pro Leu Gln 
225                 230                 235                 240 


Ser Leu Asp Leu Glu Phe Gly Ser Gly Phe Gln Pro Arg Val Leu Pro 
                245                 250                 255     


Thr Gln Pro Asn Pro Val Asp Ala Ser Arg Ala Gln Phe Phe Leu His 
            260                 265                 270         


Leu Ser Pro Ser His Tyr Ala Leu Leu Gln Tyr His Tyr Gly Thr Leu 
        275                 280                 285             


Ser Leu Leu Lys Asn Phe Pro Gln Thr Ala Leu Val Ser Phe Ala Thr 
    290                 295                 300                 


Thr Gly Glu Lys Thr Val Ala Ala Val Met Ala Cys Arg Asn Glu Val 
305                 310                 315                 320 


Gln Lys Ser Ser Ser Ser Glu Asp Gly Ser Met Gly Ser Phe Ser Glu 
                325                 330                 335     


Lys Ser Ser Ser Lys Asp Ser Leu Ala Cys Phe Asn Gln Thr Tyr Thr 
            340                 345                 350         


Ile Asn Leu Tyr Leu Val Glu Thr Gly Arg Arg Leu Leu Asp Thr Thr 
        355                 360                 365             


Ile Thr Phe Ser Leu Glu Gln Ser Gly Thr Arg Pro Glu Arg Leu Tyr 
    370                 375                 380                 


Ile Gln Val Phe Leu Lys Lys Asp Asp Ser Val Gly Tyr Arg Ala Leu 
385                 390                 395                 400 


Val Gln Thr Glu Asp His Leu Leu Leu Phe Leu Gln Gln Leu Ala Gly 
                405                 410                 415     


Lys Val Val Leu Trp Ser Arg Glu Glu Ser Leu Ala Glu Val Val Cys 
            420                 425                 430         


Leu Glu Met Val Asp Leu Pro Leu Thr Gly Ala Gln Ala Glu Leu Glu 
        435                 440                 445             


Gly Glu Phe Gly Lys Lys Ala Asp Gly Leu Leu Gly Met Phe Leu Lys 
    450                 455                 460                 


Arg Leu Ser Ser Gln Leu Ile Leu Leu Gln Ala Trp Thr Ser His Leu 
465                 470                 475                 480 


Trp Lys Met Phe Tyr Asp Ala Arg Lys Pro Arg Ser Gln Ile Lys Asn 
                485                 490                 495     


Glu Ile Asn Ile Asp Thr Leu Ala Arg Asp Glu Phe Asn Leu Gln Lys 
            500                 505                 510         


Met Met Val Met Val Thr Ala Ser Gly Lys Leu Phe Gly Ile Glu Ser 
        515                 520                 525             


Ser Ser Gly Thr Ile Leu Trp Lys Gln Tyr Leu Pro Asn Val Lys Pro 
    530                 535                 540                 


Asp Ser Ser Phe Lys Leu Met Val Gln Arg Thr Thr Ala His Phe Pro 
545                 550                 555                 560 


His Pro Pro Gln Cys Thr Leu Leu Val Lys Asp Lys Glu Ser Gly Met 
                565                 570                 575     


Ser Ser Leu Tyr Val Phe Asn Pro Ile Phe Gly Lys Trp Ser Gln Val 
            580                 585                 590         


Ala Pro Pro Val Leu Lys Arg Pro Ile Leu Gln Ser Leu Leu Leu Pro 
        595                 600                 605             


Val Met Asp Gln Asp Tyr Ala Lys Val Leu Leu Leu Ile Asp Asp Glu 
    610                 615                 620                 


Tyr Lys Val Thr Ala Phe Pro Ala Thr Arg Asn Val Leu Arg Gln Leu 
625                 630                 635                 640 


His Glu Leu Ala Pro Ser Ile Phe Phe Tyr Leu Val Asp Ala Glu Gln 
                645                 650                 655     


Gly Arg Leu Cys Gly Tyr Arg Leu Arg Lys Asp Leu Thr Thr Glu Leu 
            660                 665                 670         


Ser Trp Glu Leu Thr Ile Pro Pro Glu Val Gln Arg Ile Val Lys Val 
        675                 680                 685             


Lys Gly Lys Arg Ser Ser Glu His Val His Ser Gln Gly Arg Val Met 
    690                 695                 700                 


Gly Asp Arg Ser Val Leu Tyr Lys Ser Leu Asn Pro Asn Leu Leu Ala 
705                 710                 715                 720 


Val Val Thr Glu Ser Thr Asp Ala His His Glu Arg Thr Phe Ile Gly 
                725                 730                 735     


Ile Phe Leu Ile Asp Gly Val Thr Gly Arg Ile Ile His Ser Ser Val 
            740                 745                 750         


Gln Lys Lys Ala Lys Gly Pro Val His Ile Val His Ser Glu Asn Trp 
        755                 760                 765             


Val Val Tyr Gln Tyr Trp Asn Thr Lys Ala Arg Arg Asn Glu Phe Thr 
    770                 775                 780                 


Val Leu Glu Leu Tyr Glu Gly Thr Glu Gln Tyr Asn Ala Thr Ala Phe 
785                 790                 795                 800 


Ser Ser Leu Asp Arg Pro Gln Leu Pro Gln Val Leu Gln Gln Ser Tyr 
                805                 810                 815     


Ile Phe Pro Ser Ser Ile Ser Ala Met Glu Ala Thr Ile Thr Glu Arg 
            820                 825                 830         


Gly Ile Thr Ser Arg His Leu Leu Ile Gly Leu Pro Ser Gly Ala Ile 
        835                 840                 845             


Leu Ser Leu Pro Lys Ala Leu Leu Asp Pro Arg Arg Pro Glu Ile Pro 
    850                 855                 860                 


Thr Glu Gln Ser Arg Glu Glu Asn Leu Ile Pro Tyr Ser Pro Asp Val 
865                 870                 875                 880 


Gln Ile His Ala Glu Arg Phe Ile Asn Tyr Asn Gln Thr Val Ser Arg 
                885                 890                 895     


Met Arg Gly Ile Tyr Thr Ala Pro Ser Gly Leu Glu Ser Thr Cys Leu 
            900                 905                 910         


Val Val Ala Tyr Gly Leu Asp Ile Tyr Gln Thr Arg Val Tyr Pro Ser 
        915                 920                 925             


Lys Gln Phe Asp Val Leu Lys Asp Asp Tyr Asp Tyr Val Leu Ile Ser 
    930                 935                 940                 


Ser Val Leu Phe Gly Leu Val Phe Ala Thr Met Ile Thr Lys Arg Leu 
945                 950                 955                 960 


Ala Gln Val Lys Leu Leu Asn Arg Ala Trp Arg 
                965                 970     


<210>  4720
<211>  86
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4720

Xaa Asn Ala Thr Ala Phe Ser Ser Leu Asp Arg Pro Gln Leu Pro Gln 
1               5                   10                  15      


Val Leu Gln Gln Ser Tyr Ile Phe Pro Ser Ser Ile Ser Ala Met Glu 
            20                  25                  30          


Ala Thr Ile Thr Glu Arg Gly Ile Thr Ser Arg His Leu Leu Ile Gly 
        35                  40                  45              


Leu Pro Ser Gly Ala Ile Leu Ser Leu Pro Lys Ala Leu Leu Asp Pro 
    50                  55                  60                  


Arg Arg Pro Glu Ile Pro Thr Glu Gln Ser Arg Cys Thr Asp Thr Arg 
65                  70                  75                  80  


Arg Ala Ile His Gln Leu 
                85      


<210>  4721
<211>  191
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4721

Xaa Ser Ser Lys Asp Ser Leu Ala Cys Phe Asn Gln Thr Tyr Thr Ile 
1               5                   10                  15      


Asn Leu Tyr Leu Val Glu Thr Gly Arg Arg Leu Leu Asp Thr Thr Ile 
            20                  25                  30          


Thr Phe Ser Leu Glu Gln Ser Gly Thr Arg Pro Glu Arg Leu Tyr Ile 
        35                  40                  45              


Gln Val Phe Leu Lys Lys Asp Asp Ser Val Gly Tyr Arg Ala Leu Val 
    50                  55                  60                  


Gln Thr Glu Asp His Leu Leu Leu Phe Leu Gln Gln Leu Ala Gly Lys 
65                  70                  75                  80  


Val Val Leu Trp Ser Arg Glu Glu Ser Leu Ala Glu Val Val Cys Leu 
                85                  90                  95      


Glu Met Val Asp Leu Pro Leu Thr Gly Ala Gln Ala Glu Leu Glu Gly 
            100                 105                 110         


Glu Phe Gly Lys Lys Ala Ala Ile Gln Asp Gly Leu Leu Gly Met Phe 
        115                 120                 125             


Leu Lys Arg Leu Ser Ser Gln Leu Ile Leu Leu Gln Ala Trp Thr Ser 
    130                 135                 140                 


His Leu Trp Lys Met Phe Tyr Asp Ala Arg Lys Pro Arg Ser Gln Ile 
145                 150                 155                 160 


Lys Asn Glu Ile Asn Ile Asp Thr Leu Ala Arg Asp Glu Phe Asn Leu 
                165                 170                 175     


Gln Lys Met Met Val Met Val Thr Ala Ser Gly Lys Val Ser Gly 
            180                 185                 190     


<210>  4722
<211>  43
<212>  PRT
<213>  Homo Sapiens

<400>  4722

Met Ala Ala Ala Ser Ala Gly Ala Thr Arg Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Met Ala His Ser Phe Glu Ile Asp Asp Ser Ala Asn Phe Arg Lys Arg 
            20                  25                  30          


Gly Ser Leu Leu Trp Asn Gln Gln Asp Gly Thr 
        35                  40              


<210>  4723
<211>  254
<212>  PRT
<213>  Homo Sapiens

<400>  4723

Met Ala Ala Ala Ser Ala Gly Ala Thr Arg Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Met Ala Val Ala Ala Pro Ser Arg Ala Arg Gly Ser Gly Cys Arg Ala 
            20                  25                  30          


Gly Thr Gly Ala Arg Gly Ala Gly Ala Glu Gly Arg Glu Gly Glu Ala 
        35                  40                  45              


Cys Gly Thr Val Gly Leu Leu Leu Glu His Ser Phe Glu Ile Asp Asp 
    50                  55                  60                  


Ser Ala Asn Phe Arg Lys Arg Gly Ser Leu Leu Trp Asn Gln Gln Asp 
65                  70                  75                  80  


Gly Thr Leu Ser Leu Ser Gln Arg Gln Leu Ser Glu Glu Glu Arg Gly 
                85                  90                  95      


Arg Leu Arg Asp Val Ala Ala Leu Asn Gly Leu Tyr Arg Val Arg Ile 
            100                 105                 110         


Pro Arg Arg Pro Gly Ala Leu Asp Gly Leu Glu Ala Gly Gly Tyr Val 
        115                 120                 125             


Ser Ser Phe Val Pro Ala Cys Ser Leu Val Glu Ser His Leu Ser Asp 
    130                 135                 140                 


Gln Leu Thr Leu His Val Asp Val Ala Gly Asn Val Val Gly Val Ser 
145                 150                 155                 160 


Val Val Thr His Pro Gly Gly Cys Arg Gly His Glu Val Glu Asp Val 
                165                 170                 175     


Asp Leu Glu Leu Phe Asn Thr Ser Val Gln Leu Gln Pro Pro Thr Thr 
            180                 185                 190         


Ala Pro Gly Pro Glu Thr Ala Ala Phe Ile Glu Arg Leu Glu Met Glu 
        195                 200                 205             


Gln Ala Gln Lys Ala Lys Asn Pro Gln Glu Gln Lys Ser Phe Phe Ala 
    210                 215                 220                 


Lys Tyr Trp His Ile Ile Leu Gly Gly Ala Val Leu Leu Thr Ala Leu 
225                 230                 235                 240 


Arg Pro Ala Ala Pro Gly Pro Ala Pro Pro Pro Gln Glu Ala 
                245                 250                 


<210>  4724
<211>  262
<212>  PRT
<213>  Homo Sapiens

<400>  4724

Met Ala Ala Ala Ser Ala Gly Ala Thr Arg Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Met Ala Val Ala Ala Pro Ser Arg Ala Arg Gly Ser Gly Cys Arg Ala 
            20                  25                  30          


Gly Thr Gly Ala Arg Gly Ala Gly Ala Glu Gly Arg Glu Gly Glu Ala 
        35                  40                  45              


Cys Gly Thr Val Gly Leu Leu Leu Glu His Ser Phe Glu Ile Asp Asp 
    50                  55                  60                  


Ser Ala Asn Phe Arg Lys Arg Gly Ser Leu Leu Trp Asn Gln Gln Asp 
65                  70                  75                  80  


Gly Thr Leu Ser Leu Ser Gln Arg Gln Leu Ser Glu Glu Glu Arg Gly 
                85                  90                  95      


Arg Leu Arg Asp Val Ala Ala Leu Asn Gly Leu Tyr Arg Val Arg Ile 
            100                 105                 110         


Pro Arg Arg Pro Gly Ala Leu Asp Gly Leu Glu Ala Gly Gly Tyr Val 
        115                 120                 125             


Ser Ser Phe Val Pro Ala Cys Ser Leu Val Glu Ser His Leu Ser Asp 
    130                 135                 140                 


Gln Leu Thr Leu His Val Asp Val Ala Gly Asn Val Val Gly Val Ser 
145                 150                 155                 160 


Val Val Thr His Pro Gly Gly Cys Arg Gly His Glu Val Glu Asp Val 
                165                 170                 175     


Asp Leu Glu Leu Phe Asn Thr Ser Val Gln Leu Gln Pro Pro Thr Thr 
            180                 185                 190         


Ala Pro Gly Pro Glu Thr Ala Ala Phe Ile Glu Arg Leu Glu Met Glu 
        195                 200                 205             


Gln Ala Gln Lys Ala Lys Asn Pro Gln Glu Gln Lys Ser Phe Phe Ala 
    210                 215                 220                 


Lys Tyr Trp Met Tyr Ile Ile Pro Val Val Leu Phe Leu Met Met Ser 
225                 230                 235                 240 


Gly Ala Pro Asp Thr Gly Gly Gln Gly Gly Gly Gly Gly Gly Gly Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Arg 
            260         


<210>  4725
<211>  371
<212>  PRT
<213>  Homo Sapiens

<400>  4725

Met Ala Ala Ala Ser Ala Gly Ala Thr Arg Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Met Ala Val Ala Ala Pro Ser Arg Ala Arg Gly Ser Gly Cys Arg Ala 
            20                  25                  30          


Gly Thr Gly Ala Arg Gly Ala Gly Ala Glu Gly Arg Glu Gly Glu Ala 
        35                  40                  45              


Cys Gly Thr Val Gly Leu Leu Leu Glu His Ser Phe Glu Ile Asp Asp 
    50                  55                  60                  


Ser Ala Asn Phe Arg Lys Arg Gly Ser Leu Leu Trp Asn Gln Gln Asp 
65                  70                  75                  80  


Gly Thr Leu Ser Leu Ser Gln Arg Gln Leu Ser Glu Glu Glu Arg Gly 
                85                  90                  95      


Arg Leu Arg Asp Val Ala Ala Leu Asn Gly Leu Tyr Arg Val Arg Ile 
            100                 105                 110         


Pro Arg Arg Pro Gly Ala Leu Asp Gly Leu Glu Ala Gly Gly Tyr Val 
        115                 120                 125             


Ser Ser Phe Val Pro Ala Cys Ser Leu Val Glu Ser His Leu Ser Asp 
    130                 135                 140                 


Gln Leu Thr Leu His Val Asp Val Ala Gly Asn Val Val Gly Val Ser 
145                 150                 155                 160 


Val Val Thr His Pro Gly Gly Cys Arg Gly His Glu Val Glu Asp Val 
                165                 170                 175     


Asp Leu Glu Leu Phe Asn Thr Ser Val Gln Leu Gln Pro Pro Thr Thr 
            180                 185                 190         


Ala Pro Gly Pro Glu Thr Ala Ala Phe Ile Glu Arg Leu Glu Met Glu 
        195                 200                 205             


Gln Ala Gln Lys Ala Lys Asn Pro Gln Glu Gln Lys Ser Phe Phe Ala 
    210                 215                 220                 


Lys Tyr Trp Met Tyr Ile Ile Pro Val Val Leu Phe Leu Met Met Ser 
225                 230                 235                 240 


Gly Ala Pro Asp Thr Gly Gly Gln Gly Gly Gly Gly Gly Gly Gly Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Arg Pro Leu Ser Ser Ala Phe Cys Trp Gln Arg 
            260                 265                 270         


Ser Ser Trp Thr Gly Ala Phe Gly Thr Ala Ala Gly Val Ser Cys Ala 
        275                 280                 285             


Arg Leu Pro His Gly Pro Met Gln Pro Gln Gly Leu Pro Pro Cys Pro 
    290                 295                 300                 


Trp Ser Arg Ala Arg Asp Pro Gly His Tyr Ala Ser Ser Asp Leu Ala 
305                 310                 315                 320 


Ser Pro Tyr Pro Glu Pro Met Gln Ser Gly Asn Met Pro Pro Ser Leu 
                325                 330                 335     


Gln Pro Leu Cys Leu Cys Ser Arg Trp Ser His Pro Pro Val Pro Gly 
            340                 345                 350         


Trp Ala Arg Trp Ser Cys Pro Gly Ser Cys Ser Ala Pro Leu Thr Leu 
        355                 360                 365             


Thr Leu Asp 
    370     


<210>  4726
<211>  42
<212>  PRT
<213>  Homo Sapiens

<400>  4726

Met Ala Ala Ala Ser Ala Gly Ala Thr Arg Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Met Ala Val Ala Ala Pro Ser Arg Ala Arg Gly Ser Gly Cys Arg Ala 
            20                  25                  30          


Gly Thr Gly Ala Arg Gly Val Ser Ala Leu 
        35                  40          


<210>  4727
<211>  42
<212>  PRT
<213>  Homo Sapiens

<400>  4727

Met Ala Ala Ala Ser Ala Gly Ala Thr Arg Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Met Ala Val Ala Ala Pro Ser Arg Ala Arg Gly Ser Gly Cys Arg Ala 
            20                  25                  30          


Gly Thr Gly Ala Arg Gly Val Ser Ala Leu 
        35                  40          


<210>  4728
<211>  89
<212>  PRT
<213>  Homo Sapiens

<400>  4728

Met Leu Val Ile Pro Ala Leu Arg Glu Ala Glu Ala Gly Gly Pro Leu 
1               5                   10                  15      


Glu Val Arg Ser Ser Arg Pro Ala Cys Ser Lys Trp Leu Gly Arg Lys 
            20                  25                  30          


Val Glu Arg Ala Arg Pro Val Ala Arg Trp Gly Cys Cys Trp Ser Thr 
        35                  40                  45              


His Leu Arg Ser Met Thr Val Pro Thr Ser Gly Ser Gly Ala His Cys 
    50                  55                  60                  


Ser Gly Thr Ser Arg Met Val Pro Cys Pro Cys His Ser Gly Ser Ser 
65                  70                  75                  80  


Ala Arg Arg Ser Gly Ala Asp Ser Gly 
                85                  


<210>  4729
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  4729

Met Gly Glu Val Glu Ile Ser Ala Leu Ala Tyr Val Lys Met Cys Leu 
1               5                   10                  15      


His Ala Ala Arg Tyr Pro His Ala Ala Val Asn Gly Leu Phe Leu Ala 
            20                  25                  30          


Pro Ala Pro Arg Ser Gly Glu Cys Leu Cys Leu Thr Asp Cys Val Pro 
        35                  40                  45              


Leu Phe His Ser His Leu Ala Leu Ser Val Met Leu Glu Val Ala Leu 
    50                  55                  60                  


Asn Gln Val Asp Val Trp Gly Ala Gln Ala Gly Leu Val Val Ala Gly 
65                  70                  75                  80  


Tyr Tyr His Ala Asn Ala Ala Val Asn Asp Gln Ser Asn Ile 
                85                  90                  


<210>  4730
<211>  208
<212>  PRT
<213>  Homo Sapiens

<400>  4730

Met Gly Glu Val Glu Ile Ser Ala Leu Ala Tyr Val Lys Met Cys Leu 
1               5                   10                  15      


His Ala Ala Arg Tyr Pro His Ala Ala Val Asn Gly Leu Phe Leu Ala 
            20                  25                  30          


Pro Ala Pro Arg Ser Gly Glu Cys Leu Cys Leu Thr Asp Cys Val Pro 
        35                  40                  45              


Leu Phe His Ser His Leu Ala Leu Ser Val Met Leu Glu Val Ala Leu 
    50                  55                  60                  


Asn Gln Val Asp Val Trp Gly Ala Gln Ala Gly Leu Val Val Ala Gly 
65                  70                  75                  80  


Tyr Tyr His Ala Asn Ala Ala Val Asn Asp Gln Ser Pro Gly Pro Leu 
                85                  90                  95      


Ala Leu Lys Ile Ala Gly Arg Ile Ala Glu Phe Phe Pro Asp Ala Val 
            100                 105                 110         


Leu Ile Met Leu Asp Asn Gln Lys Leu Val Pro Gln Pro Arg Val Pro 
        115                 120                 125             


Pro Val Ile Val Leu Glu Asn Gln Gly Leu Arg Trp Val Pro Lys Asp 
    130                 135                 140                 


Lys Asn Leu Val Met Trp Arg Asp Trp Glu Glu Ser Arg Gln Met Val 
145                 150                 155                 160 


Gly Ala Leu Leu Glu Asp Arg Ala His Gln His Leu Val Asp Phe Asp 
                165                 170                 175     


Cys His Leu Asp Asp Ile Arg Gln Asp Trp Thr Asn Gln Arg Leu Asn 
            180                 185                 190         


Thr Gln Ile Thr Gln Trp Val Gly Pro Thr Asn Gly Asn Gly Asn Ala 
        195                 200                 205             


<210>  4731
<211>  208
<212>  PRT
<213>  Homo Sapiens

<400>  4731

Met Gly Glu Val Glu Ile Ser Ala Leu Ala Tyr Val Lys Met Cys Leu 
1               5                   10                  15      


His Ala Ala Arg Tyr Pro His Ala Ala Val Asn Gly Leu Phe Leu Ala 
            20                  25                  30          


Pro Ala Pro Arg Ser Gly Glu Cys Leu Cys Leu Thr Asp Cys Val Pro 
        35                  40                  45              


Leu Phe His Ser His Leu Ala Leu Ser Val Met Leu Glu Val Ala Leu 
    50                  55                  60                  


Asn Gln Val Asp Val Trp Gly Ala Gln Ala Gly Leu Val Val Ala Gly 
65                  70                  75                  80  


Tyr Tyr His Ala Asn Ala Ala Val Asn Asp Gln Ser Pro Gly Pro Leu 
                85                  90                  95      


Ala Leu Lys Ile Ala Gly Arg Ile Ala Glu Phe Phe Pro Asp Ala Val 
            100                 105                 110         


Leu Ile Met Leu Asp Asn Gln Lys Leu Val Pro Gln Pro Arg Val Pro 
        115                 120                 125             


Pro Val Ile Val Leu Glu Asn Gln Gly Leu Arg Trp Val Pro Lys Asp 
    130                 135                 140                 


Lys Asn Leu Val Met Trp Arg Asp Trp Glu Glu Ser Arg Gln Met Val 
145                 150                 155                 160 


Gly Ala Leu Leu Glu Asp Arg Ala His Gln His Leu Val Asp Phe Asp 
                165                 170                 175     


Cys His Leu Asp Asp Ile Arg Gln Asp Trp Thr Asn Gln Arg Leu Asn 
            180                 185                 190         


Thr Gln Ile Thr Gln Trp Val Gly Pro Thr Asn Gly Asn Gly Asn Ala 
        195                 200                 205             


<210>  4732
<211>  134
<212>  PRT
<213>  Homo Sapiens

<400>  4732

Met Gly Phe Ala His Ser Trp Leu Leu Thr Pro Leu Ile Phe Pro Leu 
1               5                   10                  15      


His Ser Pro Gly Pro Leu Ala Leu Lys Ile Ala Gly Arg Ile Ala Glu 
            20                  25                  30          


Phe Phe Pro Asp Ala Val Leu Ile Met Leu Asp Asn Gln Lys Leu Val 
        35                  40                  45              


Pro Gln Pro Arg Val Pro Pro Val Ile Val Leu Glu Asn Gln Gly Leu 
    50                  55                  60                  


Arg Trp Val Pro Lys Asp Lys Asn Leu Val Met Trp Arg Asp Trp Glu 
65                  70                  75                  80  


Glu Ser Arg Gln Met Val Gly Ala Leu Leu Glu Asp Arg Ala His Gln 
                85                  90                  95      


His Leu Val Asp Phe Asp Cys His Leu Asp Asp Ile Arg Gln Asp Trp 
            100                 105                 110         


Thr Asn Gln Arg Leu Asn Thr Gln Ile Thr Gln Trp Val Gly Pro Thr 
        115                 120                 125             


Asn Gly Asn Gly Asn Ala 
    130                 


<210>  4733
<211>  76
<212>  PRT
<213>  Homo Sapiens

<400>  4733

Leu Met Ser Thr Ala Thr Phe Leu Thr Ser Lys Asp Glu Gly Leu Lys 
1               5                   10                  15      


Ala Thr Thr Thr Asp Val Arg Lys Asn Asp Ser Ile Ile Ser Asn Val 
            20                  25                  30          


Thr Val Thr Ser Val Thr Leu Pro Asn Ala Val Ser Thr Leu Gln Ser 
        35                  40                  45              


Ser Lys Pro Lys Thr Glu Thr Gln Ser Ser Ile Lys Thr Thr Glu Ile 
    50                  55                  60                  


Pro Gly Glu His Ser Ala Gln Gly Lys Thr Lys Asn 
65                  70                  75      


<210>  4734
<211>  248
<212>  PRT
<213>  Homo Sapiens

<400>  4734

Met Glu Leu Leu Gln Val Thr Ile Leu Phe Leu Leu Pro Ser Ile Cys 
1               5                   10                  15      


Ser Ser Asn Ser Thr Gly Val Leu Glu Ala Ala Asn Asn Ser Leu Val 
            20                  25                  30          


Val Thr Thr Thr Lys Pro Ser Ile Thr Thr Pro Asn Thr Glu Ser Leu 
        35                  40                  45              


Gln Lys Asn Val Val Thr Pro Thr Thr Gly Thr Thr Pro Lys Gly Thr 
    50                  55                  60                  


Ile Thr Asn Glu Leu Leu Lys Met Ser Leu Met Ser Thr Ala Thr Phe 
65                  70                  75                  80  


Leu Thr Ser Lys Asp Glu Gly Leu Lys Ala Thr Thr Thr Asp Val Arg 
                85                  90                  95      


Lys Asn Asp Ser Ile Ile Ser Asn Val Thr Val Thr Ser Val Thr Leu 
            100                 105                 110         


Pro Asn Ala Val Ser Thr Leu Gln Ser Ser Lys Pro Lys Ser Ser Val 
        115                 120                 125             


Leu Gln Pro Asp Ala Ser Pro Ser Lys Thr Gly Thr Leu Thr Ser Ile 
    130                 135                 140                 


Pro Val Thr Ile Pro Glu Asn Thr Ser Gln Ser Gln Val Ile Gly Thr 
145                 150                 155                 160 


Glu Gly Gly Lys Asn Ala Ser Thr Ser Ala Thr Ser Arg Ser Tyr Ser 
                165                 170                 175     


Ser Ile Ile Leu Pro Val Val Ile Ala Leu Ile Val Ile Thr Leu Ser 
            180                 185                 190         


Val Phe Val Leu Val Gly Leu Tyr Arg Met Cys Trp Lys Ala Asp Pro 
        195                 200                 205             


Gly Thr Pro Glu Asn Gly Asn Asp Gln Pro Gln Ser Asp Lys Glu Ser 
    210                 215                 220                 


Val Lys Leu Leu Thr Val Lys Thr Ile Ser His Glu Ser Gly Glu His 
225                 230                 235                 240 


Ser Ala Gln Gly Lys Thr Lys Asn 
                245             


<210>  4735
<211>  165
<212>  PRT
<213>  Homo Sapiens

<400>  4735

Met Glu Leu Leu Gln Val Thr Ile Leu Phe Leu Leu Pro Ser Ile Cys 
1               5                   10                  15      


Ser Ser Asn Ser Thr Gly Val Leu Glu Ala Ala Asn Asn Ser Leu Val 
            20                  25                  30          


Val Thr Thr Thr Lys Pro Ser Ile Thr Thr Pro Asn Thr Glu Ser Leu 
        35                  40                  45              


Gln Lys Asn Val Val Thr Pro Thr Thr Gly Thr Thr Pro Lys Gly Thr 
    50                  55                  60                  


Ile Thr Asn Glu Leu Leu Lys Met Ser Leu Met Ser Thr Ala Thr Phe 
65                  70                  75                  80  


Leu Thr Ser Lys Asp Glu Gly Leu Lys Ala Thr Thr Thr Asp Val Arg 
                85                  90                  95      


Lys Asn Asp Ser Ile Ile Ser Asn Val Thr Val Thr Ser Val Thr Leu 
            100                 105                 110         


Pro Asn Ala Val Ser Thr Leu Gln Ser Ser Lys Pro Lys Thr Glu Thr 
        115                 120                 125             


Gln Ser Ser Ile Lys Thr Thr Glu Ile Pro Gly Ile Ile Leu Pro Val 
    130                 135                 140                 


Val Ile Ala Leu Ile Val Ile Thr Leu Ser Val Phe Val Leu Val Gly 
145                 150                 155                 160 


Leu Tyr Arg Met Cys 
                165 


<210>  4736
<211>  261
<212>  PRT
<213>  Homo Sapiens

<400>  4736

Met Glu Leu Leu Gln Val Thr Ile Leu Phe Leu Leu Pro Ser Ile Cys 
1               5                   10                  15      


Ser Ser Asn Ser Thr Gly Val Leu Glu Ala Ala Asn Asn Ser Leu Val 
            20                  25                  30          


Val Thr Thr Thr Lys Pro Ser Ile Thr Thr Pro Asn Thr Glu Ser Leu 
        35                  40                  45              


Gln Lys Asn Val Val Thr Pro Thr Thr Gly Thr Thr Pro Lys Gly Thr 
    50                  55                  60                  


Ile Thr Asn Glu Leu Leu Lys Met Ser Leu Met Ser Thr Ala Thr Phe 
65                  70                  75                  80  


Leu Thr Ser Lys Asp Glu Gly Leu Lys Ala Thr Thr Thr Asp Val Arg 
                85                  90                  95      


Lys Asn Asp Ser Ile Ile Ser Asn Val Thr Val Thr Ser Val Thr Leu 
            100                 105                 110         


Pro Asn Ala Val Ser Thr Leu Gln Ser Ser Lys Pro Lys Thr Glu Thr 
        115                 120                 125             


Gln Ser Ser Ile Lys Thr Thr Glu Ile Pro Gly Ser Val Leu Gln Pro 
    130                 135                 140                 


Asp Ala Ser Pro Ser Lys Thr Gly Thr Leu Thr Ser Ile Pro Val Thr 
145                 150                 155                 160 


Ile Pro Glu Asn Thr Ser Gln Ser Gln Val Ile Gly Thr Glu Gly Gly 
                165                 170                 175     


Lys Asn Ala Ser Thr Ser Ala Thr Ser Arg Ser Tyr Ser Ser Ile Ile 
            180                 185                 190         


Leu Pro Val Val Ile Ala Leu Ile Val Ile Thr Leu Ser Val Phe Val 
        195                 200                 205             


Leu Val Gly Leu Tyr Arg Met Cys Trp Lys Ala Asp Pro Gly Thr Pro 
    210                 215                 220                 


Glu Asn Gly Asn Asp Gln Pro Gln Ser Asp Lys Glu Ser Val Lys Leu 
225                 230                 235                 240 


Leu Thr Val Lys Thr Ile Ser His Glu Ser Gly Glu His Ser Ala Gln 
                245                 250                 255     


Gly Lys Thr Lys Asn 
            260     


<210>  4737
<211>  178
<212>  PRT
<213>  Homo Sapiens

<400>  4737

Met Glu Leu Leu Gln Val Thr Ile Leu Phe Leu Leu Pro Ser Ile Cys 
1               5                   10                  15      


Ser Ser Asn Ser Thr Gly Val Leu Glu Ala Ala Asn Asn Ser Leu Val 
            20                  25                  30          


Val Thr Thr Thr Lys Pro Ser Ile Thr Thr Pro Asn Thr Glu Ser Leu 
        35                  40                  45              


Gln Lys Asn Val Val Thr Pro Thr Thr Gly Thr Thr Pro Lys Gly Thr 
    50                  55                  60                  


Ile Thr Asn Glu Leu Leu Lys Met Ser Leu Met Ser Thr Ala Thr Phe 
65                  70                  75                  80  


Leu Thr Ser Lys Asp Glu Gly Leu Lys Ala Thr Thr Thr Asp Val Arg 
                85                  90                  95      


Lys Asn Asp Ser Ile Ile Ser Asn Val Thr Val Thr Ser Val Thr Leu 
            100                 105                 110         


Pro Asn Ala Val Ser Thr Leu Gln Ser Ser Lys Pro Lys Thr Glu Thr 
        115                 120                 125             


Gln Ser Ser Ile Lys Thr Thr Glu Ile Pro Gly Thr Pro Glu Asn Gly 
    130                 135                 140                 


Asn Asp Gln Pro Gln Ser Asp Lys Glu Ser Val Lys Leu Leu Thr Val 
145                 150                 155                 160 


Lys Thr Ile Ser His Glu Ser Gly Glu His Ser Ala Gln Gly Lys Thr 
                165                 170                 175     


Lys Asn 
        


<210>  4738
<211>  34
<212>  PRT
<213>  Homo Sapiens

<400>  4738

Met Gly Gly Pro Arg Ala Trp Ala Leu Leu Cys Leu Gly Leu Leu Leu 
1               5                   10                  15      


Pro Gly Gly Gly Ala Ala Trp Ser Ile Gly Ala Ala Pro Phe Ser Gly 
            20                  25                  30          


Arg Arg 
        


<210>  4739
<211>  175
<212>  PRT
<213>  Homo Sapiens

<400>  4739

Met Gly Gly Pro Arg Ala Trp Ala Leu Leu Cys Leu Gly Leu Leu Leu 
1               5                   10                  15      


Pro Gly Gly Gly Ala Ala Trp Ser Ile Gly Ala Ala Pro Phe Ser Gly 
            20                  25                  30          


Arg Arg Asn Trp Cys Ser Tyr Val Val Thr Arg Thr Ile Ser Cys His 
        35                  40                  45              


Val Gln Asn Gly Thr Tyr Leu Gln Arg Val Leu Gln Asn Cys Pro Trp 
    50                  55                  60                  


Pro Met Ser Cys Pro Gly Ser Ser Tyr Arg Thr Val Val Arg Pro Thr 
65                  70                  75                  80  


Tyr Lys Val Met Tyr Lys Ile Val Thr Ala Arg Glu Trp Arg Cys Cys 
                85                  90                  95      


Pro Gly His Ser Gly Val Ser Cys Glu Glu Gly Cys Leu Asn Cys Ser 
            100                 105                 110         


Lys Val Ser Glu Leu Thr Glu Arg Leu Lys Val Leu Glu Ala Lys Met 
        115                 120                 125             


Thr Met Leu Thr Val Ile Glu Gln Pro Val Pro Pro Thr Pro Ala Thr 
    130                 135                 140                 


Pro Glu Asp Pro Ala Pro Leu Trp Gly Pro Pro Pro Ala Gln Gly Ser 
145                 150                 155                 160 


Pro Gly Asp Gly Gly Leu Gln Asp Gln Val Gly Ala Trp Gly Leu 
                165                 170                 175 


<210>  4740
<211>  443
<212>  PRT
<213>  Homo Sapiens

<400>  4740

Met Gly Gly Pro Arg Ala Trp Ala Leu Leu Cys Leu Gly Leu Leu Leu 
1               5                   10                  15      


Pro Gly Gly Gly Ala Ala Trp Ser Ile Gly Ala Ala Pro Phe Ser Gly 
            20                  25                  30          


Arg Arg Asn Trp Cys Ser Tyr Val Val Thr Arg Thr Ile Ser Cys His 
        35                  40                  45              


Val Gln Asn Gly Thr Tyr Leu Gln Arg Val Leu Gln Asn Cys Pro Trp 
    50                  55                  60                  


Pro Met Ser Cys Pro Gly Ser Ser Tyr Arg Thr Val Val Arg Pro Thr 
65                  70                  75                  80  


Tyr Lys Val Met Tyr Lys Ile Val Thr Ala Arg Glu Trp Arg Cys Cys 
                85                  90                  95      


Pro Gly His Ser Gly Val Ser Cys Glu Glu Val Ala Ala Ser Ser Ala 
            100                 105                 110         


Ser Leu Glu Pro Met Trp Ser Gly Ser Thr Met Arg Arg Met Ala Leu 
        115                 120                 125             


Arg Pro Thr Ala Phe Ser Gly Cys Leu Asn Cys Ser Lys Val Ser Glu 
    130                 135                 140                 


Leu Thr Glu Arg Leu Lys Val Leu Glu Ala Lys Met Thr Met Leu Thr 
145                 150                 155                 160 


Val Ile Glu Gln Pro Val Pro Pro Thr Pro Ala Thr Pro Glu Asp Pro 
                165                 170                 175     


Ala Pro Leu Trp Gly Pro Pro Pro Ala Gln Gly Ser Pro Gly Asp Gly 
            180                 185                 190         


Gly Leu Gln Asp Gln Val Gly Ala Trp Gly Leu Pro Gly Pro Thr Gly 
        195                 200                 205             


Pro Lys Gly Asp Ala Gly Ser Arg Gly Pro Met Gly Met Arg Gly Pro 
    210                 215                 220                 


Pro Gly Pro Gln Gly Pro Pro Gly Ser Pro Gly Arg Ala Gly Ala Val 
225                 230                 235                 240 


Gly Thr Pro Gly Glu Arg Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
                245                 250                 255     


Pro Pro Gly Pro Pro Ala Pro Val Gly Pro Pro His Ala Arg Ile Ser 
            260                 265                 270         


Gln His Gly Asp Pro Leu Leu Ser Asn Thr Phe Thr Glu Thr Asn Asn 
        275                 280                 285             


His Trp Pro Gln Gly Pro Thr Gly Pro Pro Gly Pro Pro Gly Pro Met 
    290                 295                 300                 


Gly Pro Pro Gly Pro Pro Gly Pro Thr Gly Val Pro Gly Ser Pro Gly 
305                 310                 315                 320 


His Ile Gly Pro Pro Gly Pro Thr Gly Pro Lys Gly Ile Ser Gly His 
                325                 330                 335     


Pro Gly Glu Lys Gly Glu Arg Gly Leu Arg Gly Glu Pro Gly Pro Gln 
            340                 345                 350         


Gly Ser Ala Gly Gln Arg Gly Glu Pro Gly Pro Lys Gly Asp Pro Gly 
        355                 360                 365             


Glu Lys Ser His Trp Gly Glu Gly Leu His Gln Leu Arg Glu Ala Leu 
    370                 375                 380                 


Lys Ile Leu Ala Glu Arg Val Leu Ile Leu Glu Thr Met Ile Gly Leu 
385                 390                 395                 400 


Tyr Glu Pro Glu Leu Gly Ser Gly Ala Gly Pro Ala Gly Thr Gly Thr 
                405                 410                 415     


Pro Ser Leu Leu Arg Gly Lys Arg Gly Gly His Ala Thr Asn Tyr Arg 
            420                 425                 430         


Ile Val Ala Pro Arg Ser Arg Asp Glu Arg Gly 
        435                 440             


<210>  4741
<211>  422
<212>  PRT
<213>  Homo Sapiens

<400>  4741

Met Gly Gly Pro Arg Ala Trp Ala Leu Leu Cys Leu Gly Leu Leu Leu 
1               5                   10                  15      


Pro Gly Gly Gly Ala Ala Trp Ser Ile Gly Ala Ala Pro Phe Ser Gly 
            20                  25                  30          


Arg Arg Asn Trp Cys Ser Tyr Val Val Thr Arg Thr Ile Ser Cys His 
        35                  40                  45              


Val Gln Asn Gly Thr Tyr Leu Gln Arg Val Leu Gln Asn Cys Pro Trp 
    50                  55                  60                  


Pro Met Ser Cys Pro Gly Ser Ser Tyr Arg Thr Val Val Arg Pro Thr 
65                  70                  75                  80  


Tyr Lys Val Met Tyr Lys Ile Val Thr Ala Arg Glu Trp Arg Cys Cys 
                85                  90                  95      


Pro Gly His Ser Gly Val Ser Cys Glu Glu Val Ala Ala Ser Ser Ala 
            100                 105                 110         


Ser Leu Glu Pro Met Trp Ser Gly Ser Thr Met Arg Arg Met Ala Leu 
        115                 120                 125             


Arg Pro Thr Ala Phe Ser Gly Cys Leu Asn Cys Ser Lys Val Ser Glu 
    130                 135                 140                 


Leu Thr Glu Arg Leu Lys Val Leu Glu Ala Lys Met Thr Met Leu Thr 
145                 150                 155                 160 


Val Ile Glu Gln Pro Val Pro Pro Thr Pro Ala Thr Pro Glu Asp Pro 
                165                 170                 175     


Ala Pro Leu Trp Gly Pro Pro Pro Ala Gln Gly Ser Pro Gly Asp Gly 
            180                 185                 190         


Gly Leu Gln Asp Gln Val Gly Ala Trp Gly Leu Pro Gly Pro Thr Gly 
        195                 200                 205             


Pro Lys Gly Asp Ala Gly Ser Arg Gly Pro Met Gly Met Arg Gly Pro 
    210                 215                 220                 


Pro Gly Pro Gln Gly Pro Pro Gly Ser Pro Gly Arg Ala Gly Ala Val 
225                 230                 235                 240 


Gly Thr Pro Gly Glu Arg Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
                245                 250                 255     


Pro Pro Gly Pro Pro Ala Pro Val Gly Pro Pro His Ala Arg Ile Ser 
            260                 265                 270         


Gln His Gly Asp Pro Leu Leu Ser Asn Thr Phe Thr Glu Thr Asn Asn 
        275                 280                 285             


His Trp Pro Gln Gly Pro Thr Gly Pro Pro Gly Pro Pro Gly Pro Met 
    290                 295                 300                 


Gly Pro Pro Gly Pro Pro Gly Pro Thr Gly Val Pro Gly Ser Pro Gly 
305                 310                 315                 320 


His Ile Gly Leu Arg Gly Glu Pro Gly Pro Gln Gly Ser Ala Gly Gln 
                325                 330                 335     


Arg Gly Glu Pro Gly Pro Lys Gly Asp Pro Gly Glu Lys Ser His Trp 
            340                 345                 350         


Gly Glu Gly Leu His Gln Leu Arg Glu Ala Leu Lys Ile Leu Ala Glu 
        355                 360                 365             


Arg Val Leu Ile Leu Glu Thr Met Ile Gly Leu Tyr Glu Pro Glu Leu 
    370                 375                 380                 


Gly Ser Gly Ala Gly Pro Ala Gly Thr Gly Thr Pro Ser Leu Leu Arg 
385                 390                 395                 400 


Gly Lys Arg Gly Gly His Ala Thr Asn Tyr Arg Ile Val Ala Pro Arg 
                405                 410                 415     


Ser Arg Asp Glu Arg Gly 
            420         


<210>  4742
<211>  445
<212>  PRT
<213>  Homo Sapiens

<400>  4742

Met Gly Gly Pro Arg Ala Trp Ala Leu Leu Cys Leu Gly Leu Leu Leu 
1               5                   10                  15      


Pro Gly Gly Gly Ala Ala Trp Ser Ile Gly Ala Ala Pro Phe Ser Gly 
            20                  25                  30          


Arg Arg Asn Trp Cys Ser Tyr Val Val Thr Arg Thr Ile Ser Cys His 
        35                  40                  45              


Val Gln Asn Gly Thr Tyr Leu Gln Arg Val Leu Gln Asn Cys Pro Trp 
    50                  55                  60                  


Pro Met Ser Cys Pro Gly Ser Ser Tyr Arg Thr Val Val Arg Pro Thr 
65                  70                  75                  80  


Tyr Lys Val Met Tyr Lys Ile Val Thr Ala Arg Glu Trp Arg Cys Cys 
                85                  90                  95      


Pro Gly His Ser Gly Val Ser Cys Glu Glu Val Ala Ala Ser Ser Ala 
            100                 105                 110         


Ser Leu Glu Pro Met Trp Ser Gly Ser Thr Met Arg Arg Met Ala Leu 
        115                 120                 125             


Arg Pro Thr Ala Phe Ser Gly Cys Leu Asn Cys Ser Lys Val Ser Glu 
    130                 135                 140                 


Leu Thr Glu Arg Leu Lys Val Leu Glu Ala Lys Met Thr Met Leu Thr 
145                 150                 155                 160 


Val Ile Glu Gln Pro Val Pro Pro Thr Pro Ala Thr Pro Glu Asp Pro 
                165                 170                 175     


Ala Pro Leu Trp Gly Pro Pro Pro Ala Gln Gly Ser Pro Gly Asp Gly 
            180                 185                 190         


Gly Leu Gln Asp Gln Val Gly Ala Trp Gly Leu Pro Gly Pro Thr Gly 
        195                 200                 205             


Pro Lys Gly Asp Ala Gly Ser Arg Gly Pro Met Gly Met Arg Gly Pro 
    210                 215                 220                 


Pro Gly Pro Gln Gly Pro Pro Gly Ser Pro Gly Arg Ala Gly Ala Val 
225                 230                 235                 240 


Gly Thr Pro Gly Glu Arg Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
                245                 250                 255     


Pro Pro Gly Pro Pro Ala Pro Val Gly Pro Pro His Ala Arg Ile Ser 
            260                 265                 270         


Gln His Gly Asp Pro Leu Leu Ser Asn Thr Phe Thr Glu Thr Asn Asn 
        275                 280                 285             


His Trp Pro Gln Gly Pro Thr Gly Pro Pro Gly Pro Pro Gly Pro Met 
    290                 295                 300                 


Gly Pro Pro Gly Pro Pro Gly Pro Thr Gly Val Pro Gly Ser Pro Gly 
305                 310                 315                 320 


His Ile Gly Pro Pro Gly Pro Thr Gly Pro Lys Gly Ile Ser Gly His 
                325                 330                 335     


Pro Gly Glu Lys Gly Glu Arg Gly Leu Arg Gly Glu Pro Gly Pro Gln 
            340                 345                 350         


Gly Ser Ala Gly Gln Arg Gly Glu Pro Gly Pro Lys Gly Asp Pro Gly 
        355                 360                 365             


Glu Lys Ser His Trp Ala Pro Ser Leu Gln Ser Phe Leu Gln Gln Gln 
    370                 375                 380                 


Ala Gln Leu Glu Leu Leu Ala Arg Arg Val Thr Leu Leu Glu Ala Ile 
385                 390                 395                 400 


Ile Trp Pro Glu Pro Glu Leu Gly Ser Gly Ala Gly Pro Ala Gly Thr 
                405                 410                 415     


Gly Thr Pro Ser Leu Leu Arg Gly Lys Arg Gly Gly His Ala Thr Asn 
            420                 425                 430         


Tyr Arg Ile Val Ala Pro Arg Ser Arg Asp Glu Arg Gly 
        435                 440                 445 


<210>  4743
<211>  212
<212>  PRT
<213>  Homo Sapiens

<400>  4743

Met Gly Gly Pro Arg Ala Trp Ala Leu Leu Cys Leu Gly Leu Leu Leu 
1               5                   10                  15      


Pro Gly Gly Gly Ala Ala Trp Ser Ile Gly Ala Ala Pro Phe Ser Gly 
            20                  25                  30          


Arg Arg Asn Trp Cys Ser Tyr Val Val Thr Arg Thr Ile Ser Cys His 
        35                  40                  45              


Val Gln Asn Gly Thr Tyr Leu Gln Arg Val Leu Gln Asn Cys Pro Trp 
    50                  55                  60                  


Pro Met Ser Cys Pro Gly Ser Ser Tyr Arg Thr Val Val Arg Pro Thr 
65                  70                  75                  80  


Tyr Lys Val Met Tyr Lys Ile Val Thr Ala Arg Glu Trp Arg Cys Cys 
                85                  90                  95      


Pro Gly His Ser Gly Val Ser Cys Glu Glu Val Ala Ala Ser Ser Ala 
            100                 105                 110         


Ser Leu Glu Pro Met Trp Ser Gly Ser Thr Met Arg Arg Met Ala Leu 
        115                 120                 125             


Arg Pro Thr Ala Phe Ser Gly Cys Leu Asn Cys Ser Lys Val Ser Glu 
    130                 135                 140                 


Leu Thr Glu Arg Leu Lys Val Leu Glu Ala Lys Met Thr Met Leu Thr 
145                 150                 155                 160 


Val Ile Glu Gln Pro Val Pro Pro Thr Pro Ala Thr Pro Glu Asp Pro 
                165                 170                 175     


Ala Pro Leu Trp Gly Pro Pro Pro Ala Gln Gly Ser Pro Gly Asp Gly 
            180                 185                 190         


Gly Leu Gln Gly Asp Pro Leu Leu Ser Asn Thr Phe Thr Glu Thr Asn 
        195                 200                 205             


Asn His Trp Pro 
    210         


<210>  4744
<211>  236
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4744

Xaa Met Thr Met Leu Thr Val Ile Glu Gln Pro Val Pro Pro Thr Pro 
1               5                   10                  15      


Ala Thr Pro Glu Asp Pro Ala Pro Leu Trp Gly Pro Pro Pro Ala Gln 
            20                  25                  30          


Gly Ser Pro Gly Asp Gly Gly Leu Gln Gly Leu Pro Gly Ala Ile Glu 
        35                  40                  45              


Ser Val Arg Val Pro Leu Leu Pro Arg Asn Asp Gln Val Gly Ala Trp 
    50                  55                  60                  


Gly Leu Pro Gly Pro Thr Gly Pro Lys Gly Asp Ala Gly Ser Arg Gly 
65                  70                  75                  80  


Pro Met Gly Met Arg Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly Ser 
                85                  90                  95      


Pro Gly Arg Ala Gly Ala Val Gly Thr Pro Gly Glu Arg Gly Pro Pro 
            100                 105                 110         


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Ala Pro Val Gly 
        115                 120                 125             


Pro Pro His Ala Arg Ile Ser Gln His Gly Asp Pro Leu Leu Ser Asn 
    130                 135                 140                 


Thr Phe Thr Glu Thr Asn Asn His Trp Pro Gln Gly Pro Thr Gly Pro 
145                 150                 155                 160 


Pro Gly Pro Pro Gly Pro Met Gly Pro Pro Gly Pro Pro Gly Pro Thr 
                165                 170                 175     


Gly Val Pro Gly Ser Pro Gly His Ile Gly Pro Pro Gly Pro Thr Gly 
            180                 185                 190         


Pro Lys Gly Ile Ser Gly His Pro Gly Glu Lys Gly Glu Arg Gly Leu 
        195                 200                 205             


Arg Gly Glu Pro Gly Pro Gln Gly Ser Ala Gly Gln Arg Gly Glu Pro 
    210                 215                 220                 


Gly Pro Lys Gly Asp Pro Gly Glu Lys Ser His Trp 
225                 230                 235     


<210>  4745
<211>  1016
<212>  PRT
<213>  Homo Sapiens

<400>  4745

Met Ala Pro Arg Thr Leu Trp Ser Cys Tyr Leu Cys Cys Leu Leu Thr 
1               5                   10                  15      


Ala Ala Ala Gly Ala Ala Ser Tyr Pro Pro Arg Gly Phe Ser Leu Tyr 
            20                  25                  30          


Thr Gly Ser Ser Gly Ala Leu Ser Pro Gly Gly Pro Gln Ala Gln Ile 
        35                  40                  45              


Ala Pro Arg Pro Ala Ser Arg His Arg Asn Trp Cys Ala Tyr Val Val 
    50                  55                  60                  


Thr Arg Thr Val Ser Cys Val Leu Glu Asp Gly Val Glu Thr Tyr Val 
65                  70                  75                  80  


Lys Tyr Gln Pro Cys Ala Trp Gly Gln Pro Gln Cys Pro Gln Ser Ile 
                85                  90                  95      


Met Tyr Arg Arg Phe Leu Arg Pro Arg Tyr Arg Val Ala Tyr Lys Thr 
            100                 105                 110         


Val Thr Asp Met Glu Trp Arg Cys Cys Gln Gly Tyr Gly Gly Asp Asp 
        115                 120                 125             


Cys Ala Glu Ser Pro Ala Pro Ala Leu Gly Pro Ala Ser Ser Thr Pro 
    130                 135                 140                 


Arg Pro Leu Ala Arg Pro Ala Arg Pro Asn Leu Ser Gly Ser Ser Ala 
145                 150                 155                 160 


Gly Ser Pro Leu Ser Gly Leu Gly Gly Glu Gly Pro Gly Glu Ser Glu 
                165                 170                 175     


Lys Val Gln Gln Leu Glu Glu Gln Val Gln Ser Leu Thr Lys Glu Leu 
            180                 185                 190         


Gln Gly Leu Arg Gly Val Leu Gln Gly Leu Ser Gly Arg Leu Ala Glu 
        195                 200                 205             


Asp Val Gln Arg Ala Val Glu Thr Ala Phe Asn Gly Arg Gln Gln Pro 
    210                 215                 220                 


Ala Asp Ala Ala Ala Arg Pro Gly Val His Glu Thr Leu Asn Glu Ile 
225                 230                 235                 240 


Gln His Gln Leu Gln Leu Leu Asp Thr Arg Val Ser Thr His Asp Gln 
                245                 250                 255     


Glu Leu Gly His Leu Asn Asn His His Gly Gly Ser Ser Ser Ser Gly 
            260                 265                 270         


Gly Ser Arg Ala Pro Ala Pro Ala Ser Ala Pro Pro Gly Pro Ser Glu 
        275                 280                 285             


Glu Leu Leu Arg Gln Leu Glu Gln Arg Leu Gln Glu Ser Cys Ser Val 
    290                 295                 300                 


Cys Leu Ala Gly Leu Asp Gly Phe Arg Arg Gln Gln Gln Glu Asp Arg 
305                 310                 315                 320 


Glu Arg Leu Arg Ala Met Glu Lys Leu Leu Ala Ser Val Glu Glu Arg 
                325                 330                 335     


Gln Arg His Leu Ala Gly Leu Ala Val Gly Arg Arg Pro Pro Gln Glu 
            340                 345                 350         


Cys Cys Ser Pro Glu Leu Gly Arg Arg Leu Ala Glu Leu Glu Arg Arg 
        355                 360                 365             


Leu Asp Val Val Ala Gly Ser Val Thr Val Leu Ser Gly Arg Arg Gly 
    370                 375                 380                 


Thr Glu Leu Gly Gly Ala Ala Gly Gln Gly Gly His Pro Pro Gly Tyr 
385                 390                 395                 400 


Thr Ser Leu Ala Ser Arg Leu Ser Arg Leu Glu Asp Arg Phe Asn Ser 
                405                 410                 415     


Thr Leu Gly Pro Ser Glu Glu Gln Glu Glu Ser Trp Pro Gly Ala Pro 
            420                 425                 430         


Gly Gly Leu Ser His Trp Leu Pro Ala Ala Arg Gly Arg Leu Glu Gln 
        435                 440                 445             


Leu Gly Gly Leu Leu Ala Asn Val Ser Gly Glu Leu Gly Gly Arg Leu 
    450                 455                 460                 


Asp Leu Leu Glu Glu Gln Val Ala Gly Ala Met Gln Ala Cys Gly Gln 
465                 470                 475                 480 


Leu Cys Ser Gly Ala Pro Gly Glu Gln Asp Ser Gln Val Ser Glu Ile 
                485                 490                 495     


Leu Ser Ala Leu Glu Arg Arg Val Leu Asp Ser Glu Gly Gln Leu Arg 
            500                 505                 510         


Leu Val Gly Ser Gly Leu His Thr Val Glu Ala Ala Gly Glu Ala Arg 
        515                 520                 525             


Gln Ala Thr Leu Glu Gly Leu Gln Glu Val Val Gly Arg Leu Gln Asp 
    530                 535                 540                 


Arg Val Asp Ala Gln Asp Glu Thr Ala Ala Glu Phe Thr Leu Arg Leu 
545                 550                 555                 560 


Asn Leu Thr Ala Ala Arg Leu Gly Gln Leu Glu Gly Leu Leu Gln Ala 
                565                 570                 575     


His Gly Asp Glu Gly Cys Gly Ala Cys Gly Gly Val Gln Glu Glu Leu 
            580                 585                 590         


Gly Arg Leu Arg Asp Gly Val Glu Arg Cys Ser Cys Pro Leu Leu Pro 
        595                 600                 605             


Pro Arg Gly Pro Gly Ala Gly Pro Gly Val Gly Gly Pro Ser Arg Gly 
    610                 615                 620                 


Pro Leu Asp Gly Phe Ser Val Phe Gly Gly Ser Ser Gly Ser Ala Leu 
625                 630                 635                 640 


Gln Ala Leu Gln Gly Glu Leu Ser Glu Val Ile Leu Ser Phe Ser Ser 
                645                 650                 655     


Leu Asn Asp Ser Leu Asn Glu Leu Gln Thr Thr Val Glu Gly Gln Gly 
            660                 665                 670         


Ala Asp Leu Ala Asp Leu Gly Ala Thr Lys Asp Arg Ile Ile Ser Glu 
        675                 680                 685             


Ile Asn Arg Leu Gln Gln Glu Ala Thr Glu His Ala Thr Glu Ser Glu 
    690                 695                 700                 


Glu Arg Phe Arg Gly Leu Glu Glu Gly Gln Ala Gln Ala Gly Gln Cys 
705                 710                 715                 720 


Pro Ser Leu Glu Gly Arg Leu Gly Arg Leu Glu Gly Val Cys Glu Arg 
                725                 730                 735     


Leu Asp Thr Val Ala Gly Gly Leu Gln Gly Leu Arg Glu Gly Leu Ser 
            740                 745                 750         


Arg His Val Ala Gly Leu Trp Ala Gly Leu Arg Glu Thr Asn Thr Thr 
        755                 760                 765             


Ser Gln Met Gln Ala Ala Leu Leu Glu Lys Leu Val Gly Gly Gln Ala 
    770                 775                 780                 


Gly Leu Gly Arg Arg Leu Gly Ala Leu Asn Ser Ser Leu Gln Leu Leu 
785                 790                 795                 800 


Glu Asp Arg Leu His Gln Leu Ser Leu Lys Asp Leu Thr Gly Pro Ala 
                805                 810                 815     


Gly Glu Ala Gly Pro Pro Gly Pro Pro Gly Leu Gln Gly Pro Pro Gly 
            820                 825                 830         


Pro Ala Gly Pro Pro Gly Ser Pro Gly Lys Asp Gly Gln Glu Gly Pro 
        835                 840                 845             


Ile Gly Pro Pro Gly Pro Gln Gly Glu Gln Gly Val Glu Gly Ala Pro 
    850                 855                 860                 


Ala Ala Pro Val Pro Gln Val Ala Phe Ser Ala Ala Leu Ser Leu Pro 
865                 870                 875                 880 


Arg Ser Glu Pro Gly Thr Val Pro Phe Asp Arg Val Leu Leu Asn Asp 
                885                 890                 895     


Gly Gly Tyr Tyr Asp Pro Glu Thr Gly Val Phe Thr Ala Pro Leu Ala 
            900                 905                 910         


Gly Arg Tyr Leu Leu Ser Ala Val Leu Thr Gly His Arg His Glu Lys 
        915                 920                 925             


Val Glu Ala Val Leu Ser Arg Ser Asn Gln Gly Val Ala Arg Val Asp 
    930                 935                 940                 


Ser Gly Gly Tyr Glu Pro Glu Gly Leu Glu Asn Lys Pro Val Ala Glu 
945                 950                 955                 960 


Ser Gln Pro Ser Pro Gly Thr Leu Gly Val Phe Ser Leu Ile Leu Pro 
                965                 970                 975     


Leu Gln Ala Gly Asp Thr Val Cys Val Asp Leu Val Met Gly Gln Leu 
            980                 985                 990         


Ala His Ser Glu Glu Pro Leu Thr  Ile Phe Ser Gly Ala  Leu Leu Tyr 
        995                 1000                 1005             


Gly Asp  Pro Glu Leu Glu His  Ala 
    1010                 1015     


<210>  4746
<211>  347
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4746

Xaa Ala Asp Leu Gly Ala Thr Lys Asp Arg Ile Ile Ser Glu Ile Asn 
1               5                   10                  15      


Arg Leu Gln Gln Glu Ala Thr Glu His Ala Thr Glu Ser Glu Glu Arg 
            20                  25                  30          


Phe Arg Gly Leu Glu Glu Gly Gln Ala Gln Ala Gly Gln Cys Pro Ser 
        35                  40                  45              


Leu Glu Gly Arg Leu Gly Arg Leu Glu Gly Val Cys Glu Arg Leu Asp 
    50                  55                  60                  


Thr Val Ala Gly Gly Leu Gln Gly Leu Arg Glu Gly Leu Ser Arg His 
65                  70                  75                  80  


Val Ala Gly Leu Trp Ala Gly Leu Arg Glu Thr Asn Thr Thr Ser Gln 
                85                  90                  95      


Met Gln Ala Ala Leu Leu Glu Lys Leu Val Gly Gly Gln Ala Gly Leu 
            100                 105                 110         


Gly Arg Arg Leu Gly Ala Leu Asn Ser Ser Leu Gln Leu Leu Glu Asp 
        115                 120                 125             


Arg Leu His Gln Leu Ser Leu Lys Asp Leu Thr Gly Glu Gly Thr Lys 
    130                 135                 140                 


Gly Pro Ala Gly Glu Ala Gly Pro Pro Gly Pro Pro Gly Leu Gln Gly 
145                 150                 155                 160 


Pro Pro Gly Pro Ala Gly Pro Pro Gly Ser Pro Gly Lys Asp Gly Gln 
                165                 170                 175     


Glu Gly Pro Ile Gly Pro Pro Gly Pro Gln Gly Glu Gln Gly Val Glu 
            180                 185                 190         


Gly Ala Pro Ala Ala Pro Val Pro Gln Val Ala Phe Ser Ala Ala Leu 
        195                 200                 205             


Ser Leu Pro Arg Ser Glu Pro Gly Thr Val Pro Phe Asp Arg Val Leu 
    210                 215                 220                 


Leu Asn Asp Gly Gly Tyr Tyr Asp Pro Glu Thr Gly Val Phe Thr Ala 
225                 230                 235                 240 


Pro Leu Ala Gly Arg Tyr Leu Leu Ser Ala Val Leu Thr Gly His Arg 
                245                 250                 255     


His Glu Lys Val Glu Ala Val Leu Ser Arg Ser Asn Gln Gly Val Ala 
            260                 265                 270         


Arg Val Asp Ser Gly Gly Tyr Glu Pro Glu Gly Leu Glu Asn Lys Pro 
        275                 280                 285             


Val Ala Glu Ser Gln Pro Ser Pro Gly Thr Leu Gly Val Phe Ser Leu 
    290                 295                 300                 


Ile Leu Pro Leu Gln Ala Gly Asp Thr Val Cys Val Asp Leu Val Met 
305                 310                 315                 320 


Gly Gln Leu Ala His Ser Glu Glu Pro Leu Thr Ile Phe Ser Gly Ala 
                325                 330                 335     


Leu Leu Tyr Gly Asp Pro Glu Leu Glu His Ala 
            340                 345         


<210>  4747
<211>  1053
<212>  PRT
<213>  Homo Sapiens

<400>  4747

Met Trp Gln Pro Arg Arg Pro Trp Pro Arg Val Pro Trp Arg Trp Ala 
1               5                   10                  15      


Leu Ala Leu Leu Ala Leu Val Gly Ala Gly Leu Cys His Ala Gly Pro 
            20                  25                  30          


Gln Pro Gly Tyr Pro Ala Arg Pro Ser Ala Arg Asn Lys Asn Trp Cys 
        35                  40                  45              


Ala Tyr Ile Val Asn Lys Asn Val Ser Cys Ser Val Leu Glu Gly Ser 
    50                  55                  60                  


Glu Ser Phe Ile Gln Ala Gln Tyr Asn Cys Ala Trp Asn Gln Met Pro 
65                  70                  75                  80  


Cys Pro Ser Ala Leu Val Tyr Arg Val Asn Phe Arg Pro Arg Tyr Val 
                85                  90                  95      


Thr Arg Tyr Lys Thr Val Thr Gln Leu Glu Trp Arg Cys Cys Pro Gly 
            100                 105                 110         


Phe Arg Gly Gly Asp Cys Gln Glu Gly Pro Lys Asp Pro Val Lys Thr 
        115                 120                 125             


Leu Arg Pro Thr Pro Ala Arg Pro Arg Asn Ser Leu Lys Lys Ala Thr 
    130                 135                 140                 


Asp Asn Glu Pro Ser Gln Phe Ser Glu Pro Arg Lys Thr Leu Ser Pro 
145                 150                 155                 160 


Thr Gly Thr Ala Gln Pro Ser Trp Gly Val Asp Pro Lys Glu Gly Pro 
                165                 170                 175     


Gln Glu Leu Gln Glu Lys Lys Ile Gln Val Leu Glu Glu Lys Val Leu 
            180                 185                 190         


Arg Leu Thr Arg Thr Val Leu Asp Leu Gln Ser Ser Leu Ala Gly Val 
        195                 200                 205             


Ser Glu Asn Leu Lys His Ala Thr Gln Asp Asp Ala Ser Arg Thr Arg 
    210                 215                 220                 


Ala Pro Gly Leu Ser Ser Gln His Pro Lys Pro Asp Thr Thr Val Ser 
225                 230                 235                 240 


Gly Asp Thr Glu Thr Gly Gln Ser Pro Gly Val Phe Asn Thr Lys Glu 
                245                 250                 255     


Ser Gly Met Lys Asp Ile Lys Ser Glu Leu Ala Glu Val Lys Asp Thr 
            260                 265                 270         


Leu Lys Asn Lys Ser Asp Lys Leu Glu Glu Leu Asp Gly Lys Val Lys 
        275                 280                 285             


Gly Tyr Glu Gly Gln Leu Arg Gln Leu Gln Glu Ala Ala Gln Gly Pro 
    290                 295                 300                 


Thr Val Thr Met Thr Thr Asn Glu Leu Tyr Gln Ala Tyr Val Asp Ser 
305                 310                 315                 320 


Lys Ile Asp Ala Leu Arg Glu Glu Leu Met Glu Gly Met Asp Arg Lys 
                325                 330                 335     


Leu Ala Asp Leu Lys Asn Ser Cys Glu Tyr Lys Leu Thr Gly Leu Gln 
            340                 345                 350         


Gln Gln Cys Asp Asp Tyr Gly Ser Ser Tyr Leu Gly Val Ile Glu Leu 
        355                 360                 365             


Ile Gly Glu Lys Glu Thr Ser Leu Arg Lys Glu Ile Asn Asn Leu Arg 
    370                 375                 380                 


Ala Arg Leu Gln Glu Pro Ser Ala Gln Ala Asn Cys Cys Asp Ser Glu 
385                 390                 395                 400 


Lys Asn Gly Asp Ile Gly Gln Gln Ile Lys Thr Leu Asp Gln Lys Ile 
                405                 410                 415     


Glu Arg Val Ala Glu Ala Thr Arg Met Leu Asn Gly Arg Leu Asp Asn 
            420                 425                 430         


Glu Phe Asp Arg Leu Ile Val Pro Glu Pro Asp Val Asp Phe Asp Ala 
        435                 440                 445             


Lys Trp Asn Glu Leu Asp Ala Arg Ile Asn Val Thr Glu Lys Asn Ala 
    450                 455                 460                 


Glu Glu His Cys Phe Tyr Ile Glu Glu Thr Leu Arg Gly Ala Ile Asn 
465                 470                 475                 480 


Gly Glu Val Gly Asp Leu Lys Gln Leu Val Asp Gln Lys Ile Gln Ser 
                485                 490                 495     


Leu Glu Asp Arg Leu Gly Ser Val Leu Leu Gln Met Thr Asn Asn Thr 
            500                 505                 510         


Gly Ala Glu Leu Ser Pro Pro Gly Ala Ala Ala Leu Pro Gly Val Ser 
        515                 520                 525             


Gly Ser Gly Asp Glu Arg Val Met Met Glu Leu Asn His Leu Lys Asp 
    530                 535                 540                 


Lys Val Gln Val Val Glu Asp Ile Cys Leu Leu Asn Ile Gln Gly Lys 
545                 550                 555                 560 


Pro His Gly Met Glu Gly Ala Leu Pro Asn Arg Glu Asp Arg Ala Val 
                565                 570                 575     


Arg Asp Ser Leu His Leu Leu Lys Ser Leu Asn Asp Thr Met His Arg 
            580                 585                 590         


Lys Phe Gln Glu Thr Glu Gln Thr Ile Gln Lys Leu Gln Gln Asp Phe 
        595                 600                 605             


Ser Phe Leu Tyr Ser Gln Leu Asn His Thr Glu Asn Asp Val Thr His 
    610                 615                 620                 


Leu Gln Lys Glu Met Ser Asn Cys Arg Ala Gly Glu Asn Ala Gly Met 
625                 630                 635                 640 


Gly Arg Phe Thr Lys Val Gly Glu Gln Glu Arg Thr Val Asp Thr Leu 
                645                 650                 655     


Pro Ser Pro Gln His Pro Val Ala His Cys Cys Ser Gln Leu Glu Glu 
            660                 665                 670         


Arg Trp Gln Arg Leu Gln Ser Gln Val Ile Ser Glu Leu Asp Ala Cys 
        675                 680                 685             


Lys Glu Cys Thr Gln Gly Val Gln Arg Glu Val Ser Met Val Glu Gly 
    690                 695                 700                 


Arg Val Ser His Met Glu Lys Thr Cys Ser Lys Leu Asp Ser Ile Ser 
705                 710                 715                 720 


Gly Asn Leu Gln Arg Ile Lys Glu Gly Leu Asn Lys His Val Ser Ser 
                725                 730                 735     


Leu Trp Asn Cys Val Arg Gln Met Asn Gly Thr Leu Arg Ser His Ser 
            740                 745                 750         


Arg Asp Ile Ser Gly Leu Lys Asn Ser Val Gln Gln Phe Tyr Ser His 
        755                 760                 765             


Val Phe Gln Ile Ser Thr Asp Leu Gln Asp Leu Val Lys Phe Gln Pro 
    770                 775                 780                 


Ser Ala Lys Ala Pro Ser Pro Pro Pro Pro Ala Glu Ala Pro Lys Glu 
785                 790                 795                 800 


Pro Leu Gln Pro Glu Pro Ala Pro Pro Arg Pro Ser Gly Pro Ala Thr 
                805                 810                 815     


Ala Glu Asp Pro Gly Arg Arg Pro Val Leu Pro Gln Arg Pro Pro Glu 
            820                 825                 830         


Glu Arg Pro Pro Gln Pro Pro Gly Ser Thr Gly Val Ile Ala Glu Thr 
        835                 840                 845             


Gly Gln Ala Gly Pro Pro Ala Gly Ala Gly Val Ser Gly Arg Gly Leu 
    850                 855                 860                 


Pro Arg Gly Val Asp Gly Gln Thr Gly Ser Gly Thr Val Pro Gly Ala 
865                 870                 875                 880 


Glu Gly Phe Ala Gly Ala Pro Gly Tyr Pro Lys Ser Pro Pro Val Ala 
                885                 890                 895     


Ser Pro Gly Ala Pro Val Pro Ser Leu Val Ser Phe Ser Ala Gly Leu 
            900                 905                 910         


Thr Gln Lys Pro Phe Pro Ser Asp Gly Gly Val Val Leu Phe Asn Lys 
        915                 920                 925             


Val Leu Val Asn Asp Gly Asp Val Tyr Asn Pro Ser Thr Gly Val Phe 
    930                 935                 940                 


Thr Ala Pro Tyr Asp Gly Arg Tyr Leu Ile Thr Ala Thr Leu Thr Pro 
945                 950                 955                 960 


Glu Arg Asp Ala Tyr Val Glu Ala Val Leu Ser Val Ser Asn Ala Ser 
                965                 970                 975     


Val Ala Gln Leu His Thr Ala Gly Tyr Arg Arg Glu Phe Leu Glu Tyr 
            980                 985                 990         


His Arg Pro Pro Gly Ala Leu His  Thr Cys Gly Gly Pro  Gly Ala Phe 
        995                 1000                 1005             


His Leu  Ile Val His Leu Lys  Ala Gly Asp Ala Val  Asn Val Val 
    1010                 1015                 1020             


Val Thr  Gly Gly Lys Leu Ala  His Thr Asp Phe Asp  Glu Met Tyr 
    1025                 1030                 1035             


Ser Thr  Phe Ser Gly Val Phe  Leu Tyr Pro Phe Leu  Ser His Leu 
    1040                 1045                 1050             


<210>  4748
<211>  766
<212>  PRT
<213>  Homo Sapiens

<400>  4748

Met Gly Arg Arg Arg Leu Leu Val Trp Leu Cys Ala Val Ala Ala Leu 
1               5                   10                  15      


Leu Ser Gly Ala Gln Ala Arg Gly Thr Pro Leu Leu Ala Arg Pro Ala 
            20                  25                  30          


Pro Pro Gly Ala Ser Arg Tyr Ser Leu Tyr Thr Thr Gly Trp Arg Pro 
        35                  40                  45              


Arg Leu Arg Pro Gly Pro His Lys Ala Leu Cys Ala Tyr Val Val His 
    50                  55                  60                  


Arg Asn Val Thr Cys Ile Leu Gln Glu Gly Ala Glu Ser Tyr Val Lys 
65                  70                  75                  80  


Ala Glu Tyr Arg Gln Cys Arg Trp Gly Pro Lys Cys Pro Gly Thr Val 
                85                  90                  95      


Thr Tyr Arg Thr Val Leu Arg Pro Lys Tyr Lys Val Gly Tyr Lys Thr 
            100                 105                 110         


Val Thr Asp Leu Ala Trp Arg Cys Cys Pro Gly Phe Thr Gly Lys Arg 
        115                 120                 125             


Cys Pro Glu His Leu Thr Asp His Gly Ala Ala Ser Pro Gln Leu Glu 
    130                 135                 140                 


Pro Glu Pro Gln Ile Pro Ser Gly Gln Leu Asp Pro Gly Pro Arg Pro 
145                 150                 155                 160 


Pro Ser Tyr Ser Arg Ala Ala Pro Ser Pro His Gly Arg Lys Gly Pro 
                165                 170                 175     


Gly Leu Phe Gly Glu Arg Leu Glu Arg Leu Glu Gly Asp Val Gln Arg 
            180                 185                 190         


Leu Ala Gln Thr Tyr Gly Thr Leu Ser Gly Leu Val Ala Ser His Glu 
        195                 200                 205             


Asp Pro Asn Arg Met Thr Gly Gly Pro Arg Ala Pro Ala Val Pro Val 
    210                 215                 220                 


Gly Phe Gly Val Ile Pro Glu Gly Leu Val Gly Pro Gly Asp Arg Ala 
225                 230                 235                 240 


Arg Gly Pro Leu Thr Pro Pro Leu Asp Glu Ile Leu Ser Lys Val Thr 
                245                 250                 255     


Glu Val Ser Asn Thr Leu Gln Thr Lys Val Gln Leu Leu Asp Lys Val 
            260                 265                 270         


His Gly Leu Ala Leu Gly His Glu Ala His Leu Gln Arg Leu Arg Glu 
        275                 280                 285             


Ala Pro Pro Ser Pro Leu Thr Ser Leu Ala Leu Leu Glu Glu Tyr Val 
    290                 295                 300                 


Asp Arg Arg Leu His Arg Leu Trp Gly Ser Leu Leu Asp Gly Phe Glu 
305                 310                 315                 320 


Gln Lys Leu Gln Gly Val Gln Ser Glu Cys Asp Leu Arg Val Gln Glu 
                325                 330                 335     


Val Arg Arg Gln Cys Glu Glu Gly Gln Ala Ala Ser Arg Arg Leu His 
            340                 345                 350         


Gln Ser Leu Asp Gly Arg Glu Leu Ala Leu Arg Gln Glu Leu Ser Gln 
        355                 360                 365             


Leu Gly Ser Gln Leu Gln Gly Leu Ser Val Ser Gly Arg Gly Ser Cys 
    370                 375                 380                 


Cys Gly Gln Leu Ala Leu Ile Asn Ala Arg Met Asp Gly Leu Glu Arg 
385                 390                 395                 400 


Ala Leu Gln Ala Val Thr Glu Thr Gln Arg Gly Pro Gly Ala Pro Ala 
                405                 410                 415     


Gly Asp Glu Leu Thr Arg Leu Ser Ala Ala Met Leu Glu Gly Gly Val 
            420                 425                 430         


Asp Gly Leu Leu Glu Gly Leu Glu Thr Leu Asn Gly Thr Glu Gly Gly 
        435                 440                 445             


Ala Arg Gly Cys Cys Leu Arg Leu Asp Met Gly Gly Trp Gly Val Gly 
    450                 455                 460                 


Gly Phe Gly Thr Met Leu Glu Glu Arg Val Gln Ser Leu Glu Glu Arg 
465                 470                 475                 480 


Leu Ala Thr Leu Ala Gly Glu Leu Ser His Asp Ser Ala Ser Pro Gly 
                485                 490                 495     


Arg Ser Ala Arg Pro Leu Val Gln Thr Glu Leu Ala Val Leu Glu Gln 
            500                 505                 510         


Arg Leu Val Ser Leu Glu Thr Ser Cys Thr Pro Ser Thr Thr Ser Ala 
        515                 520                 525             


Ile Leu Asp Ser Leu Val Ala Glu Val Lys Ala Trp Gln Ser Arg Ser 
    530                 535                 540                 


Glu Ala Leu Leu Arg Gln Val Ala Ser His Ala Ala Leu Leu Gln Gln 
545                 550                 555                 560 


Leu Asn Gly Thr Val Ala Glu Val Gln Gly Gln Leu Ala Glu Gly Thr 
                565                 570                 575     


Gly Ser Ser Leu Gln Gly Glu Ile Thr Leu Leu Lys Val Asn Leu Asn 
            580                 585                 590         


Ser Val Ser Lys Ser Leu Thr Gly Leu Ser Asp Ser Val Ser Gln Tyr 
        595                 600                 605             


Ser Asp Ala Phe Leu Ala Ala Asn Thr Ser Leu Asp Glu Arg Glu Arg 
    610                 615                 620                 


Lys Val Glu Ala Glu Val Gln Ala Ile Gln Glu Gln Val Ser Ser Gln 
625                 630                 635                 640 


Gly Ser Arg Leu Gln Ala Gly His Arg Gln Val Leu Asn Leu Arg Gly 
                645                 650                 655     


Glu Leu Glu Gln Leu Lys Ala Gly Val Ala Lys Val Ala Ser Gly Leu 
            660                 665                 670         


Ser Arg Cys Gln Asp Thr Ala Gln Lys Leu Gln His Thr Val Gly His 
        675                 680                 685             


Phe Asp Gln Arg Val Ala Gln Val Glu Gly Ala Cys Arg Arg Leu Gly 
    690                 695                 700                 


Leu Leu Ala Ala Gly Leu Asp Ser Leu Pro Thr Glu Pro Leu Arg Pro 
705                 710                 715                 720 


Arg Glu Gly Leu Trp Ser His Val Asp Gln Leu Asn Arg Thr Leu Ala 
                725                 730                 735     


Gln His Thr Gln Asp Ile Ala Arg Leu Arg Asp Asp Leu Leu Asp Cys 
            740                 745                 750         


Gln Ala Gln Leu Ala Glu Gln Val Arg Pro Gly Gln Ala Asn 
        755                 760                 765     


<210>  4749
<211>  1142
<212>  PRT
<213>  Homo Sapiens

<400>  4749

Met Leu Val Leu Arg Cys Arg Leu Gly Thr Ser Phe Pro Lys Leu Asp 
1               5                   10                  15      


Asn Leu Val Pro Lys Gly Lys Met Lys Ile Leu Leu Val Phe Leu Gly 
            20                  25                  30          


Leu Leu Gly Asn Ser Val Ala Met Pro Met His Met Pro Arg Met Pro 
        35                  40                  45              


Gly Phe Ser Ser Lys Ser Glu Glu Met Met Arg Tyr Asn Gln Phe Asn 
    50                  55                  60                  


Phe Met Asn Gly Pro His Met Ala His Leu Gly Pro Phe Phe Gly Asn 
65                  70                  75                  80  


Gly Leu Pro Gln Gln Phe Pro Gln Tyr Gln Met Pro Met Trp Pro Gln 
                85                  90                  95      


Pro Pro Pro Asn Thr Trp His Pro Arg Lys Ser Ser Ala Pro Lys Arg 
            100                 105                 110         


His Asn Lys Thr Asp Gln Thr Gln Glu Thr Gln Lys Pro Asn Gln Thr 
        115                 120                 125             


Gln Ser Lys Lys Pro Pro Gln Lys Arg Pro Leu Lys Gln Pro Ser His 
    130                 135                 140                 


Asn Gln Pro Gln Pro Glu Glu Glu Ala Gln Pro Pro Gln Ala Phe Pro 
145                 150                 155                 160 


Pro Phe Gly Asn Gly Leu Phe Pro Tyr Gln Gln Pro Pro Trp Gln Ile 
                165                 170                 175     


Pro Gln Arg Leu Pro Pro Pro Gly Tyr Gly Arg Pro Pro Ile Ser Asn 
            180                 185                 190         


Glu Glu Gly Gly Asn Pro Tyr Phe Gly Tyr Phe Gly Tyr His Gly Phe 
        195                 200                 205             


Gly Gly Arg Pro Pro Tyr Tyr Ser Glu Glu Met Phe Glu Gln Asp Phe 
    210                 215                 220                 


Glu Lys Pro Lys Glu Glu Asp Pro Pro Lys Ala Glu Ser Pro Gly Thr 
225                 230                 235                 240 


Glu Pro Thr Ala Asn Ser Thr Val Thr Glu Thr Asn Ser Thr Gln Pro 
                245                 250                 255     


Asn Pro Lys Gly Ser Gln Gly Gly Asn Asp Thr Ser Pro Thr Gly Asn 
            260                 265                 270         


Ser Thr Pro Gly Leu Asn Thr Gly Asn Asn Pro Pro Ala Gln Asn Gly 
        275                 280                 285             


Ile Gly Pro Leu Pro Ala Val Asn Ala Ser Gly Gln Gly Gly Pro Gly 
    290                 295                 300                 


Ser Gln Ile Pro Trp Arg Pro Ser Gln Pro Asn Ile Arg Glu Asn His 
305                 310                 315                 320 


Pro Tyr Pro Asn Ile Arg Asn Phe Pro Ser Gly Arg Gln Trp Tyr Phe 
                325                 330                 335     


Thr Gly Thr Val Met Gly His Arg Gln Asn Arg Pro Phe Tyr Arg Asn 
            340                 345                 350         


Gln Gln Val Gln Arg Gly Pro Arg Trp Asn Phe Phe Ala Trp Glu Arg 
        355                 360                 365             


Lys Gln Val Ala Arg Pro Gly Asn Pro Val Tyr His Lys Ala Tyr Pro 
    370                 375                 380                 


Pro Thr Ser Arg Gly Asn Tyr Pro Asn Tyr Ala Gly Asn Pro Ala Asn 
385                 390                 395                 400 


Leu Arg Arg Lys Pro Gln Gly Pro Asn Lys His Pro Val Gly Thr Thr 
                405                 410                 415     


Val Ala Pro Leu Gly Pro Lys Pro Gly Pro Val Val Arg Asn Glu Lys 
            420                 425                 430         


Ile Gln Asn Pro Lys Glu Lys Pro Leu Gly Pro Lys Glu Gln Ile Ile 
        435                 440                 445             


Val Pro Thr Lys Asn Pro Thr Ser Pro Trp Arg Asn Ser Gln Gln Tyr 
    450                 455                 460                 


Glu Val Asn Lys Ser Asn Tyr Lys Leu Pro His Ser Glu Gly Tyr Met 
465                 470                 475                 480 


Pro Val Pro Asn Phe Asn Ser Val Asp Gln His Glu Asn Ser Tyr Tyr 
                485                 490                 495     


Pro Arg Gly Asp Ser Arg Lys Val Pro Asn Ser Asp Gly Gln Thr Gln 
            500                 505                 510         


Ser Gln Asn Leu Pro Lys Gly Ile Val Leu Gly Ser Arg Arg Met Pro 
        515                 520                 525             


Tyr Glu Ser Glu Thr Asn Gln Ser Glu Leu Lys His Ser Ser Tyr Gln 
    530                 535                 540                 


Pro Ala Val Tyr Pro Glu Glu Ile Pro Ser Pro Ala Lys Glu His Phe 
545                 550                 555                 560 


Pro Ala Gly Arg Asn Thr Trp Asp His Gln Glu Ile Ser Pro Pro Phe 
                565                 570                 575     


Lys Glu Asp Pro Gly Arg Gln Glu Glu His Leu Pro His Pro Ser His 
            580                 585                 590         


Gly Ser Arg Gly Ser Val Phe Tyr Pro Glu Tyr Asn Pro Tyr Asp Pro 
        595                 600                 605             


Arg Glu Asn Ser Pro Tyr Leu Arg Gly Asn Thr Trp Asp Glu Arg Asp 
    610                 615                 620                 


Asp Ser Pro Asn Thr Met Gly Gln Lys Glu Ser Pro Leu Tyr Pro Ile 
625                 630                 635                 640 


Asn Thr Pro Asp Gln Lys Glu Ile Val Pro Tyr Asn Glu Glu Asp Pro 
                645                 650                 655     


Val Asp Pro Thr Gly Asp Glu Val Phe Pro Gly Gln Asn Arg Trp Gly 
            660                 665                 670         


Glu Glu Leu Ser Phe Lys Gly Gly Pro Thr Val Arg His Tyr Glu Gly 
        675                 680                 685             


Glu Gln Tyr Thr Ser Asn Gln Pro Lys Glu Tyr Leu Pro Tyr Ser Leu 
    690                 695                 700                 


Asp Asn Pro Ser Lys Pro Arg Glu Asp Phe Tyr Tyr Ser Glu Phe Tyr 
705                 710                 715                 720 


Pro Trp Ser Pro Asp Glu Asn Phe Pro Ser Tyr Asn Thr Ala Ser Thr 
                725                 730                 735     


Met Pro Pro Pro Ile Glu Ser Arg Gly Tyr Tyr Val Asn Asn Ala Ala 
            740                 745                 750         


Gly Pro Glu Glu Ser Thr Leu Phe Pro Ser Arg Asn Ser Trp Asp His 
        755                 760                 765             


Arg Ile Gln Ala Gln Gly Gln Arg Glu Arg Arg Pro Tyr Phe Asn Arg 
    770                 775                 780                 


Asn Ile Trp Asp Gln Ala Thr His Leu Gln Lys Ala Pro Ala Arg Pro 
785                 790                 795                 800 


Pro Asp Gln Lys Gly Asn Gln Pro Tyr Tyr Ser Asn Thr Pro Ala Gly 
                805                 810                 815     


Leu Gln Lys Asn Pro Ile Trp His Glu Gly Glu Asn Leu Asn Tyr Gly 
            820                 825                 830         


Met Gln Ile Thr Arg Met Asn Ser Pro Glu Arg Glu His Ser Ser Phe 
        835                 840                 845             


Pro Asn Phe Ile Pro Pro Ser Tyr Pro Ser Gly Gln Lys Glu Ala His 
    850                 855                 860                 


Leu Phe His Leu Ser Gln Arg Gly Ser Cys Cys Ala Gly Ser Ser Thr 
865                 870                 875                 880 


Gly Pro Lys Asp Asn Pro Leu Ala Leu Gln Asp Tyr Thr Pro Ser Tyr 
                885                 890                 895     


Gly Leu Ala Pro Gly Glu Asn Gln Asp Thr Ser Pro Leu Tyr Thr Asp 
            900                 905                 910         


Gly Ser His Thr Lys Gln Thr Arg Asp Ile Ile Ser Pro Thr Ser Ile 
        915                 920                 925             


Leu Pro Gly Gln Arg Asn Ser Ser Glu Lys Arg Glu Ser Gln Asn Pro 
    930                 935                 940                 


Phe Arg Asp Asp Val Ser Thr Leu Arg Arg Asn Thr Pro Cys Ser Ile 
945                 950                 955                 960 


Lys Asn Gln Leu Gly Gln Lys Glu Ile Met Pro Phe Pro Glu Ala Ser 
                965                 970                 975     


Ser Leu Gln Ser Lys Asn Thr Pro Cys Leu Lys Asn Asp Leu Gly Gly 
            980                 985                 990         


Asp Gly Asn Asn Ile Leu Glu Gln  Val Phe Glu Asp Asn  Gln Leu Asn 
        995                 1000                 1005             


Glu Arg  Thr Val Asp Leu Thr  Pro Glu Gln Leu Val  Ile Gly Thr 
    1010                 1015                 1020             


Pro Asp  Glu Gly Ser Asn Pro  Glu Gly Ile Gln Ser  Gln Val Gln 
    1025                 1030                 1035             


Glu Asn  Glu Ser Glu Arg Gln  Gln Gln Arg Pro Ser  Asn Ile Leu 
    1040                 1045                 1050             


His Leu  Pro Cys Phe Gly Ser  Lys Leu Ala Lys His  His Ser Ser 
    1055                 1060                 1065             


Thr Thr  Gly Thr Pro Ser Ser  Asp Gly Arg Gln Ser  Pro Phe Asp 
    1070                 1075                 1080             


Gly Asp  Ser Ile Thr Pro Thr  Glu Asn Pro Asn Thr  Leu Val Glu 
    1085                 1090                 1095             


Leu Ala  Thr Glu Glu Gln Phe  Lys Ser Ile Asn Val  Asp Pro Leu 
    1100                 1105                 1110             


Asp Ala  Asp Glu His Ser Pro  Phe Glu Phe Leu Gln  Arg Gly Thr 
    1115                 1120                 1125             


Asn Val  Gln Asp Gln Val Gln  Asp Cys Leu Leu Leu  Gln Ala 
    1130                 1135                 1140         


<210>  4750
<211>  297
<212>  PRT
<213>  Homo Sapiens

<400>  4750

Met Arg Ala Leu Arg Ala Gly Leu Thr Leu Ala Ser Gly Ala Gly Leu 
1               5                   10                  15      


Gly Ala Val Val Glu Gly Trp Arg Arg Arg Arg Glu Asp Ala Arg Ala 
            20                  25                  30          


Ala Pro Gly Leu Leu Gly Arg Leu Pro Val Leu Pro Val Ala Ala Ala 
        35                  40                  45              


Ala Glu Leu Pro Pro Val Pro Gly Gly Pro Arg Gly Pro Gly Glu Leu 
    50                  55                  60                  


Ala Lys Tyr Gly Leu Pro Gly Leu Ala Gln Leu Lys Ser Arg Glu Ser 
65                  70                  75                  80  


Tyr Val Leu Cys Tyr Asp Pro Arg Thr Arg Gly Ala Leu Trp Val Val 
                85                  90                  95      


Glu Gln Leu Arg Pro Glu Arg Leu Arg Gly Asp Gly Asp Arg Arg Glu 
            100                 105                 110         


Cys Asp Phe Arg Glu Asp Asp Ser Val His Ala Tyr His Arg Ala Thr 
        115                 120                 125             


Asn Ala Asp Tyr Arg Gly Ser Gly Phe Asp Arg Gly His Leu Ala Ala 
    130                 135                 140                 


Ala Ala Asn His Arg Trp Ser Gln Lys Ala Met Asp Asp Thr Phe Tyr 
145                 150                 155                 160 


Leu Ser Asn Val Ala Pro Gln Val Pro His Leu Asn Gln Asn Ala Trp 
                165                 170                 175     


Asn Asn Leu Glu Lys Tyr Ser Arg Ser Leu Thr Arg Ser Tyr Gln Asn 
            180                 185                 190         


Val Tyr Val Cys Thr Gly Pro Leu Phe Leu Pro Arg Thr Glu Ala Asp 
        195                 200                 205             


Gly Lys Ser Tyr Val Lys Tyr Gln Val Ile Gly Lys Asn His Val Ala 
    210                 215                 220                 


Val Pro Thr His Phe Phe Lys Val Leu Ile Leu Glu Ala Ala Gly Gly 
225                 230                 235                 240 


Gln Ile Glu Leu Arg Thr Tyr Val Met Pro Asn Ala Pro Val Asp Glu 
                245                 250                 255     


Ala Ile Pro Leu Glu Arg Phe Leu Val Pro Ile Glu Ser Ile Glu Arg 
            260                 265                 270         


Ala Ser Gly Leu Leu Phe Val Pro Asn Ile Leu Ala Arg Ala Gly Ser 
        275                 280                 285             


Leu Lys Ala Ile Thr Ala Gly Ser Lys 
    290                 295         


<210>  4751
<211>  347
<212>  PRT
<213>  Homo Sapiens

<400>  4751

Met Arg Ala Cys Ile Ser Leu Val Leu Ala Val Leu Cys Gly Leu Ala 
1               5                   10                  15      


Trp Ala Asp Leu Tyr Ser Ala Pro Thr Ser Cys Gln Gly Arg Cys Tyr 
            20                  25                  30          


Glu Ala Phe Asp Lys His His Gln Cys His Cys Asn Ala Arg Cys Gln 
        35                  40                  45              


Glu Phe Gly Asn Cys Cys Lys Asp Phe Glu Ser Leu Cys Ser Asp His 
    50                  55                  60                  


Glu Val Ser His Ser Ser Asp Ala Ile Thr Lys Glu Glu Ile Gln Ser 
65                  70                  75                  80  


Ile Ser Glu Lys Ile Tyr Arg Ala Asp Thr Asn Lys Ala Gln Lys Glu 
                85                  90                  95      


Asp Ile Val Leu Asn Ser Gln Asn Cys Ile Ser Pro Ser Glu Thr Arg 
            100                 105                 110         


Asn Gln Val Asp Arg Cys Pro Lys Pro Leu Phe Thr Tyr Val Asn Glu 
        115                 120                 125             


Lys Leu Phe Ser Lys Pro Thr Tyr Ala Ala Phe Ile Asn Leu Leu Asn 
    130                 135                 140                 


Asn Tyr Gln Arg Ala Thr Gly His Gly Glu His Phe Ser Ala Gln Glu 
145                 150                 155                 160 


Leu Ala Glu Gln Asp Ala Phe Leu Arg Glu Ile Met Lys Thr Ala Val 
                165                 170                 175     


Met Lys Glu Leu Tyr Ser Phe Leu His His Gln Asn Arg Tyr Gly Ser 
            180                 185                 190         


Glu Gln Glu Phe Val Asp Asp Leu Lys Asn Met Trp Phe Gly Leu Tyr 
        195                 200                 205             


Ser Arg Gly Asn Glu Glu Gly Asp Ser Ser Gly Phe Glu His Val Phe 
    210                 215                 220                 


Ser Gly Glu Val Lys Lys Gly Lys Val Thr Gly Phe His Asn Trp Ile 
225                 230                 235                 240 


Arg Phe Tyr Leu Glu Glu Lys Glu Gly Leu Val Asp Tyr Tyr Ser His 
                245                 250                 255     


Ile Tyr Asp Gly Pro Trp Asp Ser Tyr Pro Asp Val Leu Ala Met Gln 
            260                 265                 270         


Phe Asn Trp Asp Gly Tyr Tyr Lys Glu Val Gly Ser Ala Phe Ile Gly 
        275                 280                 285             


Ser Ser Pro Glu Phe Glu Phe Ala Leu Tyr Ser Leu Cys Phe Ile Ala 
    290                 295                 300                 


Arg Pro Gly Lys Val Cys Gln Leu Ser Leu Gly Gly Tyr Pro Leu Ala 
305                 310                 315                 320 


Val Arg Thr Tyr Thr Trp Asp Lys Ser Thr Tyr Gly Asn Gly Lys Lys 
                325                 330                 335     


Tyr Ile Ala Thr Ala Tyr Ile Val Ser Ser Thr 
            340                 345         


<210>  4752
<211>  369
<212>  PRT
<213>  Homo Sapiens

<400>  4752

Met Arg Ala Cys Ile Ser Leu Val Leu Ala Val Leu Cys Gly Leu Ala 
1               5                   10                  15      


Trp Ala Glu Asp His Lys Glu Ser Glu Pro Leu Pro Gln Leu Glu Glu 
            20                  25                  30          


Glu Thr Glu Glu Ala Leu Ala Ser Asn Leu Tyr Ser Ala Pro Thr Ser 
        35                  40                  45              


Cys Gln Gly Arg Cys Tyr Glu Ala Phe Asp Lys His His Gln Cys His 
    50                  55                  60                  


Cys Asn Ala Arg Cys Gln Glu Phe Gly Asn Cys Cys Lys Asp Phe Glu 
65                  70                  75                  80  


Ser Leu Cys Ser Asp His Glu Val Ser His Ser Ser Asp Ala Ile Thr 
                85                  90                  95      


Lys Glu Glu Ile Gln Ser Ile Ser Glu Lys Ile Tyr Arg Ala Asp Thr 
            100                 105                 110         


Asn Lys Ala Gln Lys Glu Asp Ile Val Leu Asn Ser Gln Asn Cys Ile 
        115                 120                 125             


Ser Pro Ser Glu Thr Arg Asn Gln Val Asp Arg Cys Pro Lys Pro Leu 
    130                 135                 140                 


Phe Thr Tyr Val Asn Glu Lys Leu Phe Ser Lys Pro Thr Tyr Ala Ala 
145                 150                 155                 160 


Phe Ile Asn Leu Leu Asn Asn Tyr Gln Arg Ala Thr Gly His Gly Glu 
                165                 170                 175     


His Phe Ser Ala Gln Glu Leu Ala Glu Gln Asp Ala Phe Leu Arg Glu 
            180                 185                 190         


Ile Met Lys Thr Ala Val Met Lys Glu Leu Tyr Ser Phe Leu His His 
        195                 200                 205             


Gln Asn Arg Tyr Gly Ser Glu Gln Glu Phe Val Asp Asp Leu Lys Asn 
    210                 215                 220                 


Met Trp Phe Gly Leu Tyr Ser Arg Gly Asn Glu Glu Gly Asp Ser Ser 
225                 230                 235                 240 


Gly Phe Glu His Val Phe Ser Gly Glu Val Lys Lys Gly Lys Val Thr 
                245                 250                 255     


Gly Phe His Asn Trp Ile Arg Phe Tyr Leu Glu Glu Lys Glu Gly Leu 
            260                 265                 270         


Val Asp Tyr Tyr Ser His Ile Tyr Asp Gly Pro Trp Asp Ser Tyr Pro 
        275                 280                 285             


Asp Val Leu Ala Met Gln Phe Asn Trp Asp Gly Tyr Tyr Lys Glu Val 
    290                 295                 300                 


Gly Ser Ala Phe Ile Gly Ser Ser Pro Glu Phe Glu Phe Ala Leu Tyr 
305                 310                 315                 320 


Ser Leu Cys Phe Ile Ala Arg Pro Gly Lys Val Cys Gln Leu Ser Leu 
                325                 330                 335     


Gly Gly Tyr Pro Leu Ala Val Arg Thr Tyr Thr Trp Asp Lys Ser Thr 
            340                 345                 350         


Tyr Gly Asn Gly Lys Lys Tyr Ile Ala Thr Ala Tyr Ile Val Ser Ser 
        355                 360                 365             


Thr 
    


<210>  4753
<211>  410
<212>  PRT
<213>  Homo Sapiens

<400>  4753

Met Arg Ala Cys Ile Ser Leu Val Leu Ala Val Leu Cys Gly Leu Ala 
1               5                   10                  15      


Trp Ala Gly Lys Ile Glu Ser Cys Ala Ser Arg Cys Asn Glu Lys Phe 
            20                  25                  30          


Asn Arg Asp Ala Ala Cys Gln Cys Asp Arg Arg Cys Leu Trp His Gly 
        35                  40                  45              


Asn Cys Cys Glu Asp Tyr Glu His Leu Cys Thr Glu Asp His Lys Glu 
    50                  55                  60                  


Ser Glu Pro Leu Pro Gln Leu Glu Glu Glu Thr Glu Glu Ala Leu Ala 
65                  70                  75                  80  


Ser Asn Leu Tyr Ser Ala Pro Thr Ser Cys Gln Gly Arg Cys Tyr Glu 
                85                  90                  95      


Ala Phe Asp Lys His His Gln Cys His Cys Asn Ala Arg Cys Gln Glu 
            100                 105                 110         


Phe Gly Asn Cys Cys Lys Asp Phe Glu Ser Leu Cys Ser Asp His Glu 
        115                 120                 125             


Val Ser His Ser Ser Asp Ala Ile Thr Lys Glu Glu Ile Gln Ser Ile 
    130                 135                 140                 


Ser Glu Lys Ile Tyr Arg Ala Asp Thr Asn Lys Ala Gln Lys Glu Asp 
145                 150                 155                 160 


Ile Val Leu Asn Ser Gln Asn Cys Ile Ser Pro Ser Glu Thr Arg Asn 
                165                 170                 175     


Gln Val Asp Arg Cys Pro Lys Pro Leu Phe Thr Tyr Val Asn Glu Lys 
            180                 185                 190         


Leu Phe Ser Lys Pro Thr Tyr Ala Ala Phe Ile Asn Leu Leu Asn Asn 
        195                 200                 205             


Tyr Gln Arg Ala Thr Gly His Gly Glu His Phe Ser Ala Gln Glu Leu 
    210                 215                 220                 


Ala Glu Gln Asp Ala Phe Leu Arg Glu Ile Met Lys Thr Ala Val Met 
225                 230                 235                 240 


Lys Glu Leu Tyr Ser Phe Leu His His Gln Asn Arg Tyr Gly Ser Glu 
                245                 250                 255     


Gln Glu Phe Val Asp Asp Leu Lys Asn Met Trp Phe Gly Leu Tyr Ser 
            260                 265                 270         


Arg Gly Asn Glu Glu Gly Asp Ser Ser Gly Phe Glu His Val Phe Ser 
        275                 280                 285             


Gly Glu Val Lys Lys Gly Lys Val Thr Gly Phe His Asn Trp Ile Arg 
    290                 295                 300                 


Phe Tyr Leu Glu Glu Lys Glu Gly Leu Val Asp Tyr Tyr Ser His Ile 
305                 310                 315                 320 


Tyr Asp Gly Pro Trp Asp Ser Tyr Pro Asp Val Leu Ala Met Gln Phe 
                325                 330                 335     


Asn Trp Asp Gly Tyr Tyr Lys Glu Val Gly Ser Ala Phe Ile Gly Ser 
            340                 345                 350         


Ser Pro Glu Phe Glu Phe Ala Leu Tyr Ser Leu Cys Phe Ile Ala Arg 
        355                 360                 365             


Pro Gly Lys Val Cys Gln Leu Ser Leu Gly Gly Tyr Pro Leu Ala Val 
    370                 375                 380                 


Arg Thr Tyr Thr Trp Asp Lys Ser Thr Tyr Gly Asn Gly Lys Lys Tyr 
385                 390                 395                 400 


Ile Ala Thr Ala Tyr Ile Val Ser Ser Thr 
                405                 410 


<210>  4754
<211>  76
<212>  PRT
<213>  Homo Sapiens

<400>  4754

Met Gly Ala Ala Ile Ser Gln Gly Ala Leu Ile Ala Ile Val Cys Asn 
1               5                   10                  15      


Gly Leu Val Gly Phe Leu Leu Leu Leu Leu Trp Val Ile Leu Cys Trp 
            20                  25                  30          


Ala Cys His Ser Arg Ser Ala Asp Val Asp Ser Leu Ser Glu Ser Ser 
        35                  40                  45              


Pro Asn Ser Ser Pro Gly Pro Cys Pro Glu Lys Ala Pro Pro Pro Gln 
    50                  55                  60                  


Lys Pro Ser His Glu Gly Ser Tyr Leu Leu Gln Pro 
65                  70                  75      


<210>  4755
<211>  363
<212>  PRT
<213>  Homo Sapiens

<400>  4755

Met Ala Ile Gly Ala Val Ser Leu Ala Val Ala Lys Ala Cys Ala Met 
1               5                   10                  15      


Leu Leu Asn Lys Pro Leu Tyr Leu Asn Ile Ala Leu Leu Lys His Asn 
            20                  25                  30          


Gln Glu Gln Pro Thr Thr Leu Ser Met Pro Leu Leu Met Val Ser Leu 
        35                  40                  45              


Val Ser Cys Gly Lys Ser Ser Ser Gly Lys Leu Asn Leu Met Lys Glu 
    50                  55                  60                  


Val Ile Cys Ile Pro His Pro Glu Leu Thr Thr Lys Gln Gly Val Glu 
65                  70                  75                  80  


Met Leu Met Glu Met Gln Lys His Ile Asn Lys Ile Ile Glu Met Pro 
                85                  90                  95      


Ser Pro Pro Lys Ala Glu Thr Lys Lys Gly His Asp Gly Ser Lys Arg 
            100                 105                 110         


Gly Gln Gln Gln Ile Thr Gly Lys Met Ser His Leu Gly Cys Leu Thr 
        115                 120                 125             


Ile Asn Cys Asp Ser Ile Glu Gln Pro Leu Leu Leu Ile Gln Glu Ile 
    130                 135                 140                 


Cys Ala Asn Leu Gly Leu Glu Leu Gly Thr Asn Leu His Leu Ala Ile 
145                 150                 155                 160 


Asn Cys Ala Gly His Glu Leu Met Asp Tyr Asn Lys Gly Lys Tyr Glu 
                165                 170                 175     


Val Ile Met Gly Thr Tyr Lys Asn Ala Ala Glu Met Val Asp Leu Tyr 
            180                 185                 190         


Val Asp Leu Ile Asn Lys Tyr Pro Ser Ile Ile Ala Leu Ile Asp Pro 
        195                 200                 205             


Phe Arg Lys Glu Asp Ser Glu Gln Trp Asp Ser Ile Tyr His Ala Leu 
    210                 215                 220                 


Gly Ser Arg Cys Tyr Ile Ile Ala Gly Thr Ala Ser Lys Ser Ile Ser 
225                 230                 235                 240 


Lys Leu Leu Glu Gln Gly Asn Ile Ser Ile Pro Lys Ser Asn Gly Leu 
                245                 250                 255     


Ile Ile Lys His Thr Asn Gln Thr Thr Met Ser Asp Leu Val Glu Ile 
            260                 265                 270         


Thr Asn Leu Ile Asp Ser Lys Lys His Ile Thr Val Phe Gly Ser Thr 
        275                 280                 285             


Glu Gly Glu Ser Ser Asp Asp Ser Leu Val Asp Leu Ala Val Gly Leu 
    290                 295                 300                 


Gly Val Arg Phe Ile Lys Leu Gly Gly Leu Ser Arg Gly Glu Arg Val 
305                 310                 315                 320 


Thr Lys Tyr Asn Arg Leu Leu Thr Ile Glu Glu Glu Leu Val Gln Asn 
                325                 330                 335     


Gly Thr Leu Ala Thr Ser Ser Ser Ser Cys Asp Ala Arg Ile Gly Gly 
            340                 345                 350         


Gln Glu Gln Glu Thr Met Thr Leu Val Lys Val 
        355                 360             


<210>  4756
<211>  625
<212>  PRT
<213>  Homo Sapiens

<400>  4756

Met Glu Glu Glu Gly Gly Gly Arg Ser Cys Gly Thr Thr Arg Glu Leu 
1               5                   10                  15      


Gln Lys Leu Lys Gln Gln Ala Met Glu Tyr Tyr Arg Glu Asn Asp Val 
            20                  25                  30          


Pro Arg Arg Leu Glu Glu Leu Leu Asn Ser Thr Phe Tyr Leu Gln Pro 
        35                  40                  45              


Ala Asp Val Tyr Gly His Leu Ala Asn Cys Phe Ser Lys Leu Ala Lys 
    50                  55                  60                  


Pro Pro Thr Ile Cys Lys Ile Val Gly Lys Asp Val Leu Asp Gly Leu 
65                  70                  75                  80  


Gly Leu Pro Thr Leu Gln Val Asp Ile Phe Cys Thr Ile Gln Asn Phe 
                85                  90                  95      


Pro Lys Asn Val Cys Ser Val Val Ile Ser Thr His Phe Glu Val His 
            100                 105                 110         


Glu Asn Ala Leu Pro Glu Leu Ala Lys Ala Glu Glu Ala Glu Arg Ala 
        115                 120                 125             


Ser Ala Val Ser Thr Ala Val Gln Trp Val Asn Ser Thr Ile Thr His 
    130                 135                 140                 


Glu Leu Gln Gly Met Ala Pro Ser Asp Gln Ala Glu Val Asp His Leu 
145                 150                 155                 160 


Leu Arg Ile Phe Phe Ala Ser Lys Val Gln Glu Asp Lys Gly Arg Lys 
                165                 170                 175     


Glu Leu Glu Lys Ser Leu Glu Tyr Ser Thr Val Pro Thr Pro Leu Pro 
            180                 185                 190         


Pro Val Pro Pro Pro Pro Pro Pro Pro Pro Pro Thr Lys Lys Lys Gly 
        195                 200                 205             


Gln Lys Pro Gly Arg Lys Asp Thr Ile Thr Glu Lys Pro Ile Ala Pro 
    210                 215                 220                 


Ala Glu Pro Val Glu Pro Val Leu Ser Gly Ser Met Ala Ile Gly Ala 
225                 230                 235                 240 


Val Ser Leu Ala Val Ala Lys Ala Cys Ala Met Leu Leu Asn Lys Pro 
                245                 250                 255     


Leu Tyr Leu Asn Ile Ala Leu Leu Lys His Asn Gln Glu Gln Pro Thr 
            260                 265                 270         


Thr Leu Ser Met Pro Leu Leu Met Val Ser Leu Val Ser Cys Gly Lys 
        275                 280                 285             


Ser Ser Ser Gly Lys Leu Asn Leu Met Lys Glu Val Ile Cys Ile Pro 
    290                 295                 300                 


His Pro Glu Leu Thr Thr Lys Gln Gly Val Glu Met Leu Met Glu Met 
305                 310                 315                 320 


Gln Lys His Ile Asn Lys Ile Ile Glu Met Pro Ser Pro Pro Lys Ala 
                325                 330                 335     


Glu Thr Lys Lys Gly His Asp Gly Ser Lys Arg Gly Gln Gln Gln Ile 
            340                 345                 350         


Thr Gly Lys Met Ser His Leu Gly Cys Leu Thr Ile Asn Cys Asp Ser 
        355                 360                 365             


Ile Glu Gln Pro Leu Leu Leu Ile Gln Glu Ile Cys Ala Asn Leu Gly 
    370                 375                 380                 


Leu Glu Leu Gly Thr Asn Leu His Leu Ala Ile Asn Cys Ala Gly His 
385                 390                 395                 400 


Glu Leu Met Asp Tyr Asn Lys Gly Lys Tyr Glu Val Ile Met Gly Thr 
                405                 410                 415     


Tyr Lys Asn Ala Ala Glu Met Val Asp Leu Tyr Val Asp Leu Ile Asn 
            420                 425                 430         


Lys Tyr Pro Ser Ile Ile Ala Leu Ile Asp Pro Phe Arg Lys Glu Asp 
        435                 440                 445             


Ser Glu Gln Trp Asp Ser Ile Tyr His Ala Leu Gly Ser Arg Cys Tyr 
    450                 455                 460                 


Ile Ile Ala Gly Thr Ala Ser Lys Ser Ile Ser Lys Leu Leu Glu Gln 
465                 470                 475                 480 


Gly Asn Ile Ser Ile Pro Lys Ser Asn Gly Leu Ile Ile Lys His Thr 
                485                 490                 495     


Asn Gln Thr Thr Met Ser Asp Leu Val Glu Ile Thr Asn Leu Ile Asp 
            500                 505                 510         


Ser Lys Lys His Ile Thr Val Phe Gly Ser Thr Glu Gly Glu Ser Ser 
        515                 520                 525             


Asp Asp Ser Leu Val Asp Leu Ala Val Gly Leu Gly Val Arg Phe Ile 
    530                 535                 540                 


Lys Leu Gly Gly Leu Ser Arg Gly Glu Arg Val Thr Lys Tyr Asn Arg 
545                 550                 555                 560 


Leu Leu Thr Ile Glu Glu Glu Leu Val Gln Asn Gly Thr Leu Gly Phe 
                565                 570                 575     


Lys Glu Glu His Thr Phe Phe Tyr Phe Asn Glu Glu Ala Glu Lys Ala 
            580                 585                 590         


Ala Glu Ala Leu Glu Ala Ala Ala Ala Arg Glu Pro Leu Val Pro Thr 
        595                 600                 605             


Phe Pro Thr Gln Gly Val Glu Glu Ser Ala Glu Thr Gly Ala Ser Ser 
    610                 615                 620                 


Gly 
625 


<210>  4757
<211>  628
<212>  PRT
<213>  Homo Sapiens

<400>  4757

Met Glu Glu Glu Gly Gly Gly Arg Ser Cys Gly Thr Thr Arg Glu Leu 
1               5                   10                  15      


Gln Lys Leu Lys Gln Gln Ala Met Glu Tyr Tyr Arg Glu Asn Asp Val 
            20                  25                  30          


Pro Arg Arg Leu Glu Glu Leu Leu Asn Ser Thr Phe Tyr Leu Gln Pro 
        35                  40                  45              


Ala Asp Val Tyr Gly His Leu Lys Ala Asn Cys Phe Ser Lys Leu Ala 
    50                  55                  60                  


Lys Pro Pro Thr Ile Cys Lys Ile Val Gly Lys Asp Val Leu Asp Gly 
65                  70                  75                  80  


Leu Gly Leu Pro Thr Leu Gln Val Asp Ile Phe Cys Thr Ile Gln Asn 
                85                  90                  95      


Phe Pro Lys Asn Val Cys Ser Val Val Ile Ser Thr His Phe Glu Val 
            100                 105                 110         


His Glu Asn Ala Leu Pro Glu Leu Ala Lys Ala Glu Glu Ala Glu Arg 
        115                 120                 125             


Ala Ser Ala Val Ser Thr Ala Val Gln Trp Val Asn Ser Thr Ile Thr 
    130                 135                 140                 


His Glu Leu Gln Gly Met Ala Pro Ser Asp Gln Ala Glu Val Asp His 
145                 150                 155                 160 


Leu Leu Arg Ile Phe Phe Ala Ser Lys Val Gln Glu Asp Lys Gly Arg 
                165                 170                 175     


Lys Glu Leu Glu Lys Ser Leu Glu Tyr Ser Thr Val Pro Thr Pro Leu 
            180                 185                 190         


Pro Pro Val Pro Pro Pro Pro Pro Pro Pro Pro Pro Thr Lys Lys Lys 
        195                 200                 205             


Gly Gln Lys Pro Gly Arg Lys Asp Thr Ile Thr Glu Lys Pro Ile Ala 
    210                 215                 220                 


Pro Ala Glu Pro Val Glu Pro Val Leu Ser Gly Ser Met Ala Ile Gly 
225                 230                 235                 240 


Ala Val Ser Leu Ala Val Ala Lys Ala Cys Ala Met Leu Leu Asn Lys 
                245                 250                 255     


Pro Leu Tyr Leu Asn Ile Ala Leu Leu Lys His Asn Gln Glu Gln Pro 
            260                 265                 270         


Thr Thr Leu Ser Met Pro Leu Leu Met Val Ser Leu Val Ser Cys Gly 
        275                 280                 285             


Lys Ser Ser Ser Gly Lys Leu Asn Leu Met Lys Glu Val Ile Cys Ile 
    290                 295                 300                 


Pro His Pro Glu Leu Thr Thr Lys Gln Gly Val Glu Met Leu Met Glu 
305                 310                 315                 320 


Met Gln Lys His Ile Asn Lys Ile Ile Glu Met Ala Pro Pro Ser Pro 
                325                 330                 335     


Pro Lys Ala Glu Thr Lys Lys Gly His Asp Gly Ser Lys Arg Gly Gln 
            340                 345                 350         


Gln Gln Ile Thr Gly Lys Met Ser His Leu Gly Cys Leu Thr Ile Asn 
        355                 360                 365             


Cys Asp Ser Ile Glu Gln Pro Leu Leu Leu Ile Gln Glu Ile Cys Ala 
    370                 375                 380                 


Asn Leu Gly Leu Glu Leu Gly Thr Asn Leu His Leu Ala Ile Asn Cys 
385                 390                 395                 400 


Ala Gly His Glu Leu Met Asp Tyr Asn Lys Gly Lys Tyr Glu Val Ile 
                405                 410                 415     


Met Gly Thr Tyr Lys Asn Ala Ala Glu Met Val Asp Leu Tyr Val Asp 
            420                 425                 430         


Leu Ile Asn Lys Tyr Pro Ser Ile Ile Ala Leu Ile Asp Pro Phe Arg 
        435                 440                 445             


Lys Glu Asp Ser Glu Gln Trp Asp Ser Ile Tyr His Ala Leu Gly Ser 
    450                 455                 460                 


Arg Cys Tyr Ile Ile Ala Gly Thr Ala Ser Lys Ser Ile Ser Lys Leu 
465                 470                 475                 480 


Leu Glu Gln Gly Asn Ile Ser Ile Pro Lys Ser Asn Gly Leu Ile Ile 
                485                 490                 495     


Lys His Thr Asn Gln Thr Thr Met Ser Asp Leu Val Glu Ile Thr Asn 
            500                 505                 510         


Leu Ile Asp Ser Lys Lys His Ile Thr Val Phe Gly Ser Thr Glu Gly 
        515                 520                 525             


Glu Ser Ser Asp Asp Ser Leu Val Asp Leu Ala Val Gly Leu Gly Val 
    530                 535                 540                 


Arg Phe Ile Lys Leu Gly Gly Leu Ser Arg Gly Glu Arg Val Thr Lys 
545                 550                 555                 560 


Tyr Asn Arg Leu Leu Thr Ile Glu Glu Glu Leu Val Gln Asn Gly Thr 
                565                 570                 575     


Leu Gly Phe Lys Glu Glu His Thr Phe Phe Tyr Phe Asn Glu Glu Ala 
            580                 585                 590         


Glu Lys Ala Ala Glu Ala Leu Glu Ala Ala Ala Ala Arg Glu Pro Leu 
        595                 600                 605             


Val Pro Thr Phe Pro Thr Gln Gly Val Glu Glu Ser Ala Glu Thr Gly 
    610                 615                 620                 


Ala Ser Ser Gly 
625             


<210>  4758
<211>  308
<212>  PRT
<213>  Homo Sapiens

<400>  4758

Met Glu Glu Glu Gly Gly Gly Arg Ser Cys Gly Thr Thr Arg Glu Leu 
1               5                   10                  15      


Gln Lys Leu Lys Gln Gln Ala Met Glu Tyr Tyr Arg Glu Asn Asp Val 
            20                  25                  30          


Pro Arg Arg Leu Glu Glu Leu Leu Asn Ser Thr Phe Tyr Leu Gln Pro 
        35                  40                  45              


Ala Asp Val Tyr Gly His Leu Pro Ser Pro Pro Lys Ala Glu Thr Lys 
    50                  55                  60                  


Lys Gly His Asp Gly Ser Lys Arg Gly Gln Gln Gln Ile Thr Gly Lys 
65                  70                  75                  80  


Met Ser His Leu Gly Cys Leu Thr Ile Asn Cys Asp Ser Ile Glu Gln 
                85                  90                  95      


Pro Leu Leu Leu Ile Gln Glu Ile Cys Ala Asn Leu Gly Leu Glu Leu 
            100                 105                 110         


Gly Thr Asn Leu His Leu Ala Ile Asn Cys Ala Gly His Glu Leu Met 
        115                 120                 125             


Asp Tyr Asp Ser Glu Gln Trp Asp Ser Ile Tyr His Ala Leu Gly Ser 
    130                 135                 140                 


Arg Cys Tyr Ile Ile Ala Gly Thr Ala Ser Lys Ser Ile Ser Lys Leu 
145                 150                 155                 160 


Leu Glu Gln Gly Asn Ile Ser Ile Pro Lys Ser Asn Gly Leu Ile Ile 
                165                 170                 175     


Lys His Thr Asn Gln Thr Thr Met Ser Asp Leu Val Glu Ile Thr Asn 
            180                 185                 190         


Leu Ile Asp Ser Lys Lys His Ile Thr Val Phe Gly Ser Thr Glu Gly 
        195                 200                 205             


Glu Ser Ser Asp Asp Ser Leu Val Asp Leu Ala Val Gly Leu Gly Val 
    210                 215                 220                 


Arg Phe Ile Lys Leu Gly Gly Leu Ser Arg Gly Glu Arg Val Thr Lys 
225                 230                 235                 240 


Tyr Asn Arg Leu Leu Thr Ile Glu Glu Glu Leu Val Gln Asn Gly Thr 
                245                 250                 255     


Leu Gly Phe Lys Glu Glu His Thr Phe Phe Tyr Phe Asn Glu Glu Ala 
            260                 265                 270         


Glu Lys Ala Ala Glu Ala Leu Glu Ala Ala Ala Ala Arg Glu Pro Leu 
        275                 280                 285             


Val Pro Thr Phe Pro Thr Gln Gly Val Glu Glu Ser Ala Glu Thr Gly 
    290                 295                 300                 


Ala Ser Ser Gly 
305             


<210>  4759
<211>  138
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4759

Xaa Gly Arg Ser Cys Gly Thr Thr Arg Glu Leu Gln Lys Leu Lys Gln 
1               5                   10                  15      


Gln Ala Met Glu Tyr Tyr Arg Glu Asn Asp Val Pro Arg Arg Leu Glu 
            20                  25                  30          


Glu Leu Leu Asn Ser Thr Phe Tyr Leu Gln Pro Ala Asp Val Tyr Gly 
        35                  40                  45              


His Leu Ala Asn Cys Phe Ser Lys Leu Ala Lys Pro Pro Thr Ile Cys 
    50                  55                  60                  


Lys Ile Val Gly Lys Asp Val Leu Asp Gly Leu Gly Leu Pro Thr Leu 
65                  70                  75                  80  


Gln Val Asp Ile Phe Cys Thr Ile Gln Asn Phe Pro Lys Asn Val Cys 
                85                  90                  95      


Ser Val Val Ile Ser Thr His Phe Glu Val His Glu Asn Ala Leu Pro 
            100                 105                 110         


Glu Leu Ala Lys Ala Glu Glu Ala Glu Arg Ala Ser Ala Val Ser Thr 
        115                 120                 125             


Ala Val Gln Trp Val Asn Ser Thr Ile Thr 
    130                 135             


<210>  4760
<211>  440
<212>  PRT
<213>  Homo Sapiens

<400>  4760

Met Ala Val Lys Leu Gly Thr Leu Leu Leu Ala Leu Ala Leu Gly Leu 
1               5                   10                  15      


Ala Gln Pro Ala Ser Ala Arg Arg Lys Leu Leu Val Phe Leu Leu Asp 
            20                  25                  30          


Gly Phe Arg Ser Asp Tyr Ile Ser Asp Glu Ala Leu Glu Ser Leu Pro 
        35                  40                  45              


Gly Phe Lys Glu Ile Val Ser Arg Gly Val Lys Val Asp Tyr Leu Thr 
    50                  55                  60                  


Pro Asp Phe Pro Ser Leu Ser Tyr Pro Asn Tyr Tyr Thr Leu Met Thr 
65                  70                  75                  80  


Gly Arg His Cys Glu Val His Gln Met Ile Gly Asn Tyr Met Trp Asp 
                85                  90                  95      


Pro Thr Thr Asn Lys Ser Phe Asp Ile Gly Val Asn Lys Asp Ser Leu 
            100                 105                 110         


Met Pro Leu Trp Trp Asn Gly Ser Glu Pro Leu Trp Val Thr Leu Thr 
        115                 120                 125             


Lys Ala Lys Arg Lys Val Tyr Met Tyr Tyr Trp Pro Gly Cys Glu Val 
    130                 135                 140                 


Glu Ile Leu Gly Val Arg Pro Thr Tyr Cys Leu Glu Tyr Lys Asn Val 
145                 150                 155                 160 


Pro Thr Asp Ile Asn Phe Ala Asn Ala Val Ser Asp Ala Leu Asp Ser 
                165                 170                 175     


Phe Lys Ser Gly Arg Ala Asp Leu Ala Ala Ile Tyr His Glu Arg Ile 
            180                 185                 190         


Asp Val Glu Gly His His Tyr Gly Pro Ala Ser Pro Gln Arg Lys Asp 
        195                 200                 205             


Ala Leu Lys Ala Val Asp Thr Val Leu Lys Tyr Met Thr Lys Trp Ile 
    210                 215                 220                 


Gln Glu Arg Gly Leu Gln Asp Arg Leu Asn Val Ile Ile Phe Ser Asp 
225                 230                 235                 240 


His Gly Met Thr Asp Ile Phe Trp Met Asp Lys Val Ile Glu Leu Asn 
                245                 250                 255     


Lys Tyr Ile Ser Leu Asn Asp Leu Gln Gln Val Lys Asp Arg Gly Pro 
            260                 265                 270         


Val Val Ser Leu Trp Pro Ala Pro Gly Lys His Ser Glu Ile Tyr Asn 
        275                 280                 285             


Lys Leu Ser Thr Val Glu His Met Thr Val Tyr Glu Lys Glu Ala Ile 
    290                 295                 300                 


Pro Ser Arg Phe Tyr Tyr Lys Lys Gly Lys Phe Val Ser Pro Leu Thr 
305                 310                 315                 320 


Leu Val Ala Asp Glu Gly Trp Phe Ile Thr Glu Asn Arg Glu Met Leu 
                325                 330                 335     


Pro Phe Trp Met Asn Ser Thr Gly Arg Arg Glu Gly Trp Gln Arg Gly 
            340                 345                 350         


Trp His Gly Tyr Asp Asn Glu Leu Met Asp Met Arg Gly Ile Phe Leu 
        355                 360                 365             


Ala Phe Gly Pro Asp Phe Lys Ser Asn Phe Arg Ala Ala Pro Ile Arg 
    370                 375                 380                 


Ser Val Asp Val Tyr Asn Val Met Cys Asn Val Val Gly Ile Thr Pro 
385                 390                 395                 400 


Leu Pro Asn Asn Gly Ser Trp Ser Arg Val Met Cys Met Leu Lys Gly 
                405                 410                 415     


Arg Ala Ser Thr Ala Pro Pro Val Trp Pro Ser His Cys Ala Leu Ala 
            420                 425                 430         


Leu Ile Leu Leu Phe Leu Leu Ala 
        435                 440 


<210>  4761
<211>  194
<212>  PRT
<213>  Homo Sapiens

<400>  4761

Met Ile Gly Asn Tyr Met Trp Asp Pro Thr Thr Asn Lys Ser Phe Asp 
1               5                   10                  15      


Ile Gly Val Asn Lys Asp Ser Leu Met Pro Leu Trp Trp Asn Gly Ser 
            20                  25                  30          


Glu Pro Leu Trp Val Thr Leu Thr Lys Ala Lys Arg Lys Val Tyr Met 
        35                  40                  45              


Tyr Tyr Trp Pro Gly Cys Glu Val Glu Ile Leu Gly Val Arg Pro Thr 
    50                  55                  60                  


Tyr Cys Leu Glu Tyr Lys Asn Val Pro Thr Asp Ile Asn Phe Ala Asn 
65                  70                  75                  80  


Ala Val Ser Asp Ala Leu Asp Ser Phe Lys Ser Gly Arg Ala Asp Leu 
                85                  90                  95      


Ala Ala Ile Tyr His Glu Arg Ile Asp Val Glu Gly His His Tyr Gly 
            100                 105                 110         


Pro Ala Ser Pro Gln Arg Lys Asp Ala Leu Lys Ala Val Asp Thr Val 
        115                 120                 125             


Leu Lys Tyr Met Thr Lys Trp Ile Gln Glu Arg Gly Leu Gln Asp Arg 
    130                 135                 140                 


Leu Asn Val Ile Ile Phe Ser Asp His Gly Met Thr Asp Ile Phe Trp 
145                 150                 155                 160 


Met Asp Lys Val Ile Glu Leu Asn Lys Tyr Ile Ser Leu Asn Asp Leu 
                165                 170                 175     


Gln Gln Val Lys Asp Arg Gly Pro Val Val Ser Leu Trp Pro Ala Pro 
            180                 185                 190         


Gly Lys 
        


<210>  4762
<211>  159
<212>  PRT
<213>  Homo Sapiens

<400>  4762

Leu Lys Asp Ala His Pro Lys Leu His Val Tyr Lys Lys Glu Ala Phe 
1               5                   10                  15      


Pro Glu Ala Phe His Tyr Ala Asn Asn Pro Arg Val Thr Pro Leu Leu 
            20                  25                  30          


Met Tyr Ser Asp Leu Gly Tyr Val Ile His Gly Arg Ile Asn Val Gln 
        35                  40                  45              


Phe Asn Asn Gly Glu His Gly Phe Asp Asn Lys Asp Met Asp Met Lys 
    50                  55                  60                  


Thr Ile Phe Arg Ala Val Gly Pro Ser Phe Arg Ala Gly Leu Glu Val 
65                  70                  75                  80  


Glu Pro Phe Glu Ser Val His Val Tyr Glu Leu Met Cys Arg Leu Leu 
                85                  90                  95      


Gly Ile Val Pro Glu Ala Asn Asp Gly His Leu Ala Thr Leu Leu Pro 
            100                 105                 110         


Met Leu His Thr Glu Ser Ala Leu Pro Pro Asp Gly Arg Pro Thr Leu 
        115                 120                 125             


Leu Pro Lys Gly Arg Ser Ala Leu Pro Pro Ser Ser Arg Pro Leu Leu 
    130                 135                 140                 


Val Met Gly Leu Leu Gly Thr Val Ile Leu Leu Ser Glu Val Ala 
145                 150                 155                 


<210>  4763
<211>  458
<212>  PRT
<213>  Homo Sapiens

<400>  4763

Met Arg Gly Pro Ala Val Leu Leu Thr Val Ala Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ala Pro Gly Ala Gly Ala Pro Val Gln Ser Gln Gly Ser Gln Asn Lys 
            20                  25                  30          


Leu Leu Leu Val Ser Phe Asp Gly Phe Arg Trp Asn Tyr Asp Gln Asp 
        35                  40                  45              


Val Asp Thr Pro Asn Leu Asp Ala Met Ala Arg Asp Gly Val Lys Ala 
    50                  55                  60                  


Arg Tyr Met Thr Pro Ala Phe Val Thr Met Thr Ser Pro Cys His Phe 
65                  70                  75                  80  


Thr Leu Val Thr Gly Lys Tyr Ile Glu Asn His Gly Val Val His Asn 
                85                  90                  95      


Met Tyr Tyr Asn Thr Thr Ser Lys Val Lys Leu Pro Tyr His Ala Thr 
            100                 105                 110         


Leu Gly Ile Gln Arg Trp Trp Asp Asn Gly Ser Val Pro Ile Trp Ile 
        115                 120                 125             


Thr Ala Gln Arg Gln Gly Leu Arg Ala Gly Ser Phe Phe Tyr Pro Gly 
    130                 135                 140                 


Gly Asn Val Thr Tyr Gln Gly Val Ala Val Thr Arg Ser Arg Lys Glu 
145                 150                 155                 160 


Gly Ile Ala His Asn Tyr Lys Asn Glu Thr Glu Trp Arg Ala Asn Ile 
                165                 170                 175     


Asp Thr Val Met Ala Trp Phe Thr Glu Glu Asp Leu Asp Leu Val Thr 
            180                 185                 190         


Leu Tyr Phe Gly Glu Pro Asp Ser Thr Gly His Arg Tyr Gly Pro Glu 
        195                 200                 205             


Ser Pro Glu Arg Arg Glu Met Val Arg Gln Val Asp Arg Thr Val Gly 
    210                 215                 220                 


Tyr Leu Arg Glu Ser Ile Ala Arg Asn His Leu Thr Asp Arg Leu Asn 
225                 230                 235                 240 


Leu Ile Ile Thr Ser Asp His Gly Met Thr Thr Val Asp Lys Arg Ala 
                245                 250                 255     


Gly Asp Leu Val Glu Phe His Lys Phe Pro Asn Phe Thr Phe Arg Asp 
            260                 265                 270         


Ile Glu Phe Glu Leu Leu Asp Tyr Gly Pro Asn Gly Met Leu Leu Pro 
        275                 280                 285             


Lys Glu Gly Arg Leu Glu Lys Val Tyr Asp Ala Leu Lys Asp Ala His 
    290                 295                 300                 


Pro Lys Leu His Val Tyr Lys Lys Glu Ala Phe Pro Glu Ala Phe His 
305                 310                 315                 320 


Tyr Ala Asn Asn Pro Arg Val Thr Pro Leu Leu Met Tyr Ser Asp Leu 
                325                 330                 335     


Gly Tyr Val Ile His Gly Arg Ile Asn Val Gln Phe Asn Asn Gly Glu 
            340                 345                 350         


His Gly Phe Asp Asn Lys Asp Met Asp Met Lys Thr Ile Phe Arg Ala 
        355                 360                 365             


Val Gly Pro Ser Phe Arg Ala Gly Leu Glu Val Glu Pro Phe Glu Ser 
    370                 375                 380                 


Val His Val Tyr Glu Leu Met Cys Arg Leu Leu Gly Ile Val Pro Glu 
385                 390                 395                 400 


Ala Asn Asp Gly His Leu Ala Thr Leu Leu Pro Met Leu His Thr Glu 
                405                 410                 415     


Ser Ala Leu Pro Pro Asp Gly Arg Pro Thr Leu Leu Pro Lys Gly Arg 
            420                 425                 430         


Ser Ala Leu Pro Pro Ser Ser Arg Pro Leu Leu Val Met Gly Leu Leu 
        435                 440                 445             


Gly Thr Val Ile Leu Leu Ser Glu Val Ala 
    450                 455             


<210>  4764
<211>  91
<212>  PRT
<213>  Homo Sapiens

<400>  4764

Met Ala Thr Ser Trp Gly Thr Val Phe Phe Met Leu Val Val Ser Cys 
1               5                   10                  15      


Val Cys Ser Ala Val Ser His Arg Asn Gln Gln Thr Trp Phe Glu Gly 
            20                  25                  30          


Ile Phe Leu Ser Ser Met Cys Pro Ile Asn Val Ser Ala Ser Thr Leu 
        35                  40                  45              


Tyr Gly Ile Met Phe Asp Ala Gly Ser Thr Gly Thr Arg Ile His Val 
    50                  55                  60                  


Tyr Thr Phe Val Gln Lys Met Pro Gly His Leu Trp Ser Leu Gly Lys 
65                  70                  75                  80  


Gly Gly Gly Val Arg Cys Pro Pro Glu Lys Trp 
                85                  90      


<210>  4765
<211>  211
<212>  PRT
<213>  Homo Sapiens

<400>  4765

Met Ala Thr Ser Trp Gly Thr Val Phe Phe Met Leu Val Val Ser Cys 
1               5                   10                  15      


Val Cys Ser Ala Val Ser His Arg Asn Gln Gln Thr Trp Phe Glu Gly 
            20                  25                  30          


Ile Phe Leu Ser Ser Met Cys Pro Ile Asn Val Ser Ala Ser Thr Leu 
        35                  40                  45              


Tyr Gly Ile Met Phe Asp Ala Gly Ser Thr Gly Thr Arg Ile His Val 
    50                  55                  60                  


Tyr Thr Phe Val Gln Lys Met Pro Gly Gln Leu Pro Ile Leu Glu Gly 
65                  70                  75                  80  


Glu Val Phe Asp Ser Val Lys Pro Gly Leu Ser Ala Phe Val Asp Gln 
                85                  90                  95      


Pro Lys Gln Gly Ala Glu Thr Val Gln Gly Leu Leu Glu Val Ala Lys 
            100                 105                 110         


Asp Ser Ile Pro Arg Ser His Trp Lys Lys Thr Pro Val Val Leu Lys 
        115                 120                 125             


Ala Thr Ala Gly Leu Arg Leu Leu Pro Glu His Lys Ala Lys Ala Leu 
    130                 135                 140                 


Leu Phe Glu Val Lys Glu Ile Phe Arg Lys Ser Pro Phe Leu Val Pro 
145                 150                 155                 160 


Lys Gly Ser Val Ser Ile Met Asp Gly Ser Asp Glu Gly Ile Leu Ala 
                165                 170                 175     


Trp Val Thr Val Asn Phe Leu Thr Gly Gln Leu His Gly His Arg Gln 
            180                 185                 190         


Glu Thr Val Gly Thr Leu Asp Leu Gly Gly Ala Ser Thr Gln Ile Thr 
        195                 200                 205             


Phe Leu Pro 
    210     


<210>  4766
<211>  428
<212>  PRT
<213>  Homo Sapiens

<400>  4766

Met Ala Thr Ser Trp Gly Thr Val Phe Phe Met Leu Val Val Ser Cys 
1               5                   10                  15      


Val Cys Ser Ala Val Ser His Arg Asn Gln Gln Thr Trp Phe Glu Gly 
            20                  25                  30          


Ile Phe Leu Ser Ser Met Cys Pro Ile Asn Val Ser Ala Ser Thr Leu 
        35                  40                  45              


Tyr Gly Ile Met Phe Asp Ala Gly Ser Thr Gly Thr Arg Ile His Val 
    50                  55                  60                  


Tyr Thr Phe Val Gln Lys Met Pro Gly Gln Leu Pro Ile Leu Glu Gly 
65                  70                  75                  80  


Glu Val Phe Asp Ser Val Lys Pro Gly Leu Ser Ala Phe Val Asp Gln 
                85                  90                  95      


Pro Lys Gln Gly Ala Glu Thr Val Gln Gly Leu Leu Glu Val Ala Lys 
            100                 105                 110         


Asp Ser Ile Pro Arg Ser His Trp Lys Lys Thr Pro Val Val Leu Lys 
        115                 120                 125             


Ala Thr Ala Gly Leu Arg Leu Leu Pro Glu His Lys Ala Lys Ala Leu 
    130                 135                 140                 


Leu Phe Glu Val Lys Glu Ile Phe Arg Lys Ser Pro Phe Leu Val Pro 
145                 150                 155                 160 


Lys Gly Ser Val Ser Ile Met Asp Gly Ser Asp Glu Gly Ile Leu Ala 
                165                 170                 175     


Trp Val Thr Val Asn Phe Leu Thr Gly Gln Leu His Gly His Arg Gln 
            180                 185                 190         


Glu Thr Val Gly Thr Leu Asp Leu Gly Gly Ala Ser Thr Gln Ile Thr 
        195                 200                 205             


Phe Leu Pro Gln Phe Glu Lys Thr Leu Glu Gln Thr Pro Arg Gly Tyr 
    210                 215                 220                 


Leu Thr Ser Phe Glu Met Phe Asn Ser Thr Tyr Lys Leu Tyr Thr His 
225                 230                 235                 240 


Ser Tyr Leu Gly Phe Gly Leu Lys Ala Ala Arg Leu Ala Thr Leu Gly 
                245                 250                 255     


Ala Leu Glu Thr Glu Gly Thr Asp Gly His Thr Phe Arg Ser Ala Cys 
            260                 265                 270         


Leu Pro Arg Trp Leu Glu Ala Glu Trp Ile Phe Gly Gly Val Lys Tyr 
        275                 280                 285             


Gln Tyr Gly Gly Asn Gln Glu Gly Glu Val Gly Phe Glu Pro Cys Tyr 
    290                 295                 300                 


Ala Glu Val Leu Arg Val Val Arg Gly Lys Leu His Gln Pro Glu Glu 
305                 310                 315                 320 


Val Gln Arg Gly Ser Phe Tyr Ala Phe Ser Tyr Tyr Tyr Asp Arg Ala 
                325                 330                 335     


Val Asp Thr Asp Met Ile Asp Tyr Glu Lys Gly Gly Ile Leu Lys Val 
            340                 345                 350         


Glu Asp Phe Glu Arg Lys Ala Arg Glu Val Cys Asp Asn Leu Glu Asn 
        355                 360                 365             


Phe Thr Ser Gly Ser Pro Phe Leu Cys Met Asp Leu Ser Tyr Ile Thr 
    370                 375                 380                 


Ala Leu Leu Lys Asp Gly Phe Gly Phe Ala Asp Ser Thr Val Leu Gln 
385                 390                 395                 400 


Leu Thr Lys Lys Val Asn Asn Ile Glu Thr Gly Trp Ala Leu Gly Ala 
                405                 410                 415     


Thr Phe His Leu Leu Gln Ser Leu Gly Ile Ser His 
            420                 425             


<210>  4767
<211>  407
<212>  PRT
<213>  Homo Sapiens

<400>  4767

Met Ala Thr Ser Trp Gly Thr Val Phe Phe Met Leu Val Val Ser Cys 
1               5                   10                  15      


Val Cys Ser Ala Val Ser His Arg Asn Gln Gln Thr Trp Phe Glu Gly 
            20                  25                  30          


Ile Phe Leu Ser Ser Met Cys Pro Ile Asn Val Ser Ala Ser Thr Leu 
        35                  40                  45              


Tyr Gly Ile Met Phe Asp Ala Gly Ser Thr Gly Thr Arg Ile His Val 
    50                  55                  60                  


Tyr Thr Phe Val Gln Lys Met Pro Gly Gln Leu Pro Ile Leu Glu Gly 
65                  70                  75                  80  


Glu Val Phe Asp Ser Val Lys Pro Gly Leu Ser Ala Phe Val Asp Gln 
                85                  90                  95      


Pro Lys Gln Gly Ala Glu Thr Val Gln Gly Leu Leu Glu Val Ala Lys 
            100                 105                 110         


Asp Ser Ile Pro Arg Ser His Trp Lys Lys Thr Pro Val Val Leu Lys 
        115                 120                 125             


Ala Thr Ala Gly Leu Arg Leu Leu Pro Glu His Lys Ala Lys Ala Leu 
    130                 135                 140                 


Leu Phe Glu Val Lys Glu Ile Phe Arg Lys Ser Pro Phe Leu Val Pro 
145                 150                 155                 160 


Lys Gly Ser Val Ser Ile Met Asp Gly Ser Asp Glu Gly Ile Leu Ala 
                165                 170                 175     


Trp Val Thr Val Asn Phe Leu Thr Gly Gln Leu His Gly His Arg Gln 
            180                 185                 190         


Glu Thr Val Gly Thr Leu Asp Leu Gly Gly Ala Ser Thr Gln Ile Thr 
        195                 200                 205             


Phe Leu Pro Gln Phe Glu Lys Thr Leu Glu Gln Thr Pro Arg Gly Tyr 
    210                 215                 220                 


Leu Thr Ser Phe Glu Met Phe Asn Ser Thr Tyr Lys Leu Tyr Thr His 
225                 230                 235                 240 


Ser Tyr Leu Gly Phe Gly Leu Lys Ala Ala Arg Leu Ala Thr Leu Gly 
                245                 250                 255     


Ala Leu Glu Thr Glu Gly Thr Asp Gly His Thr Phe Arg Ser Ala Cys 
            260                 265                 270         


Leu Pro Arg Trp Leu Glu Ala Glu Trp Ile Phe Gly Gly Val Lys Tyr 
        275                 280                 285             


Gln Tyr Gly Gly Asn Gln Glu Gly Glu Val Gly Phe Glu Pro Cys Tyr 
    290                 295                 300                 


Ala Glu Val Leu Arg Val Val Arg Gly Lys Leu His Gln Pro Glu Glu 
305                 310                 315                 320 


Val Gln Arg Gly Ser Phe Tyr Ala Phe Ser Tyr Tyr Tyr Asp Arg Ala 
                325                 330                 335     


Val Asp Thr Asp Met Ile Asp Tyr Glu Lys Gly Gly Ile Leu Lys Val 
            340                 345                 350         


Glu Asp Phe Glu Arg Lys Ala Arg Glu Val Cys Asp Asn Leu Glu Asn 
        355                 360                 365             


Phe Thr Ser Gly Ser Pro Phe Leu Cys Met Asp Leu Ser Tyr Ile Thr 
    370                 375                 380                 


Ala Leu Leu Lys Asp Gly Phe Gly Phe Ala Asp Ser Thr Val Leu Gln 
385                 390                 395                 400 


His Ile Ile Ser Trp Val Asn 
                405         


<210>  4768
<211>  80
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4768

Xaa Tyr Ala Phe Ser Tyr Tyr Tyr Asp Arg Ala Val Asp Thr Asp Met 
1               5                   10                  15      


Ile Asp Tyr Glu Lys Gly Gly Ile Leu Lys Val Glu Asp Phe Glu Arg 
            20                  25                  30          


Lys Ala Arg Glu Val Cys Asp Asn Leu Glu Asn Phe Thr Ser Gly Ser 
        35                  40                  45              


Pro Phe Leu Cys Met Asp Leu Ser Tyr Ile Thr Ala Leu Leu Lys Asp 
    50                  55                  60                  


Gly Phe Gly Phe Ala Asp Ser Thr Val Leu Gln Ala Ala Val Leu Arg 
65                  70                  75                  80  


<210>  4769
<211>  223
<212>  PRT
<213>  Homo Sapiens

<400>  4769

Leu Gly Ala Ser Gly Val Ser Gly Leu Thr Ala Leu Ile Leu Leu Leu 
1               5                   10                  15      


Val Glu Ala Thr Ser Val Leu Leu Pro Thr Asp Ile Lys Phe Gly Ile 
            20                  25                  30          


Val Phe Asp Ala Gly Ser Ser His Thr Ser Leu Phe Leu Tyr Gln Trp 
        35                  40                  45              


Leu Ala Asn Lys Glu Asn Gly Thr Gly Val Val Ser Gln Ala Leu Ala 
    50                  55                  60                  


Cys Gln Val Glu Gly Pro Gly Ile Ser Ser Tyr Thr Ser Asn Ala Ala 
65                  70                  75                  80  


Gln Ala Gly Glu Ser Leu Gln Gly Cys Leu Glu Glu Ala Leu Val Leu 
                85                  90                  95      


Ile Pro Glu Ala Gln His Arg Lys Thr Pro Thr Phe Leu Gly Ala Thr 
            100                 105                 110         


Ala Gly Met Arg Leu Leu Ser Ser His Pro Gly Pro Gly Pro Val Ser 
        115                 120                 125             


Arg Gly Leu Leu Gly Cys Arg Ala Pro Gly Arg Ala Gly Arg Arg Cys 
    130                 135                 140                 


Leu Trp Leu Asp His Cys Gln Leu Arg Leu Gly Asp Ala Gly Gln Val 
145                 150                 155                 160 


Leu Leu His Trp Arg Met Asp Pro Ala Ser Gly Gly Asp Ala Gly Gly 
                165                 170                 175     


Cys Pro Gly His Gly Arg Gly Leu His Pro Asp His Val Arg Ala Trp 
            180                 185                 190         


Gly Pro His Leu Gly Gln Glu His Pro Gly Arg Phe Ser Pro Leu Arg 
        195                 200                 205             


Leu Arg Leu Gln Arg Leu His Ser Gln Leu Pro Val Leu Trp Thr 
    210                 215                 220             


<210>  4770
<211>  458
<212>  PRT
<213>  Homo Sapiens

<400>  4770

Met Gly Leu Ser Arg Lys Glu Gln Val Phe Leu Ala Leu Leu Gly Ala 
1               5                   10                  15      


Ser Gly Val Ser Gly Leu Thr Ala Leu Ile Leu Leu Leu Val Glu Ala 
            20                  25                  30          


Thr Ser Val Leu Leu Pro Thr Asp Ile Lys Phe Gly Ile Val Phe Asp 
        35                  40                  45              


Ala Gly Ser Ser His Thr Ser Leu Phe Leu Tyr Gln Trp Leu Ala Asn 
    50                  55                  60                  


Lys Glu Asn Gly Thr Gly Val Val Ser Gln Ala Leu Ala Cys Gln Val 
65                  70                  75                  80  


Glu Gly Pro Gly Ile Ser Ser Tyr Thr Ser Asn Ala Ala Gln Ala Gly 
                85                  90                  95      


Glu Ser Leu Gln Gly Cys Leu Glu Glu Ala Leu Val Leu Ile Pro Glu 
            100                 105                 110         


Ala Gln His Arg Lys Thr Pro Thr Phe Leu Gly Ala Thr Ala Gly Met 
        115                 120                 125             


Arg Leu Leu Ser Arg Lys Asn Ser Ser Gln Ala Arg Asp Ile Phe Ala 
    130                 135                 140                 


Ala Val Thr Gln Val Leu Gly Arg Ser Pro Val Asp Phe Trp Gly Ala 
145                 150                 155                 160 


Glu Leu Leu Ala Gly Gln Ala Glu Gly Ala Phe Gly Trp Ile Thr Val 
                165                 170                 175     


Asn Tyr Gly Leu Gly Thr Leu Val Lys Tyr Ser Phe Thr Gly Glu Trp 
            180                 185                 190         


Ile Gln Pro Pro Glu Glu Met Leu Val Gly Ala Leu Asp Met Gly Gly 
        195                 200                 205             


Ala Ser Thr Gln Ile Thr Phe Val Pro Gly Gly Pro Ile Leu Asp Lys 
    210                 215                 220                 


Ser Thr Gln Ala Asp Phe Arg Leu Tyr Gly Ser Asp Tyr Ser Val Tyr 
225                 230                 235                 240 


Thr His Ser Tyr Leu Cys Phe Gly Arg Asp Gln Met Leu Ser Arg Leu 
                245                 250                 255     


Leu Val Gly Leu Val Gln Ser Arg Pro Ala Ala Leu Leu Arg His Pro 
            260                 265                 270         


Cys Tyr Leu Ser Gly Tyr Gln Thr Thr Leu Ala Leu Gly Pro Leu Tyr 
        275                 280                 285             


Glu Ser Pro Cys Val His Ala Thr Pro Pro Leu Ser Leu Pro Gln Asn 
    290                 295                 300                 


Leu Thr Val Glu Gly Thr Gly Asn Pro Gly Ala Cys Val Ser Ala Ile 
305                 310                 315                 320 


Arg Glu Leu Phe Asn Phe Ser Ser Cys Gln Gly Gln Glu Asp Cys Ala 
                325                 330                 335     


Phe Asp Gly Val Tyr Gln Pro Pro Leu Arg Gly Gln Phe Tyr Val Glu 
            340                 345                 350         


Ala Ser Tyr Pro Gly Gln Asp Arg Trp Leu Arg Asp Tyr Cys Ala Ser 
        355                 360                 365             


Gly Leu Tyr Ile Leu Thr Leu Leu His Glu Gly Tyr Gly Phe Ser Glu 
    370                 375                 380                 


Glu Thr Trp Pro Ser Leu Glu Phe Arg Lys Gln Ala Gly Gly Val Asp 
385                 390                 395                 400 


Ile Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Gly Met Ile Pro 
                405                 410                 415     


Ala Asp Ala Pro Ala Gln Trp Arg Ala Glu Ser Tyr Gly Val Trp Val 
            420                 425                 430         


Ala Lys Val Val Phe Met Val Leu Ala Leu Val Ala Val Val Gly Ala 
        435                 440                 445             


Ala Leu Val Gln Leu Phe Trp Leu Gln Asp 
    450                 455             


<210>  4771
<211>  495
<212>  PRT
<213>  Homo Sapiens

<400>  4771

Met Gly Leu Ser Arg Lys Glu Gln Val Phe Leu Ala Leu Leu Gly Ala 
1               5                   10                  15      


Ser Gly Val Ser Gly Leu Thr Ala Leu Ile Leu Leu Leu Val Glu Ala 
            20                  25                  30          


Thr Ser Val Leu Leu Pro Thr Asp Ile Lys Phe Gly Ile Val Phe Asp 
        35                  40                  45              


Ala Gly Ser Ser His Thr Ser Leu Phe Leu Tyr Gln Trp Leu Ala Asn 
    50                  55                  60                  


Lys Glu Asn Gly Thr Gly Val Val Ser Gln Ala Leu Ala Cys Gln Val 
65                  70                  75                  80  


Glu Gly Pro Gly Ile Ser Ser Tyr Thr Ser Asn Ala Ala Gln Ala Gly 
                85                  90                  95      


Glu Ser Leu Gln Gly Cys Leu Glu Glu Ala Leu Val Leu Ile Pro Glu 
            100                 105                 110         


Ala Gln His Arg Lys Thr Pro Thr Phe Leu Gly Ala Thr Ala Gly Met 
        115                 120                 125             


Arg Leu Leu Ser Arg Lys Asn Ser Ser Gln Ala Arg Asp Ile Phe Ala 
    130                 135                 140                 


Ala Val Thr Gln Val Leu Gly Arg Ser Pro Val Asp Phe Trp Gly Ala 
145                 150                 155                 160 


Glu Leu Leu Ala Gly Gln Ala Glu Gly Ala Phe Gly Trp Ile Thr Val 
                165                 170                 175     


Asn Tyr Gly Leu Gly Thr Leu Val Lys Tyr Ser Phe Thr Gly Glu Trp 
            180                 185                 190         


Ile Gln Pro Pro Glu Glu Met Leu Val Gly Ala Leu Asp Met Gly Gly 
        195                 200                 205             


Ala Ser Thr Gln Ile Thr Phe Val Pro Gly Gly Pro Ile Leu Asp Lys 
    210                 215                 220                 


Ser Thr Gln Ala Asp Phe Arg Leu Tyr Gly Ser Asp Tyr Ser Val Tyr 
225                 230                 235                 240 


Thr His Ser Tyr Leu Cys Phe Gly Arg Asp Gln Met Leu Ser Arg Leu 
                245                 250                 255     


Leu Val Gly Leu Val Gln Ser Arg Pro Ala Ala Leu Leu Arg His Pro 
            260                 265                 270         


Cys Tyr Leu Ser Gly Tyr Gln Thr Thr Leu Ala Leu Gly Pro Leu Tyr 
        275                 280                 285             


Glu Ser Pro Cys Val His Ala Thr Pro Pro Leu Ser Leu Pro Gln Asn 
    290                 295                 300                 


Leu Thr Val Glu Gly Thr Gly Asn Pro Gly Ala Cys Val Ser Ala Ile 
305                 310                 315                 320 


Arg Glu Leu Phe Asn Phe Ser Ser Cys Gln Gly Gln Glu Asp Cys Ala 
                325                 330                 335     


Phe Asp Gly Val Tyr Gln Pro Pro Leu Arg Gly Gln Phe Tyr Ala Phe 
            340                 345                 350         


Ser Asn Phe Tyr Tyr Thr Phe His Phe Leu Asn Leu Thr Ser Arg Gln 
        355                 360                 365             


Pro Leu Ser Thr Val Asn Ala Thr Ile Trp Glu Phe Cys Gln Arg Pro 
    370                 375                 380                 


Trp Lys Leu Val Glu Ala Ser Tyr Pro Gly Gln Asp Arg Trp Leu Arg 
385                 390                 395                 400 


Asp Tyr Cys Ala Ser Gly Leu Tyr Ile Leu Thr Leu Leu His Glu Gly 
                405                 410                 415     


Tyr Gly Phe Ser Glu Glu Thr Trp Pro Ser Leu Glu Phe Arg Lys Gln 
            420                 425                 430         


Ala Gly Gly Val Asp Ile Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu 
        435                 440                 445             


Thr Gly Met Ile Pro Ala Asp Ala Pro Ala Gln Trp Arg Ala Glu Ser 
    450                 455                 460                 


Tyr Gly Val Trp Val Ala Lys Val Val Phe Met Val Leu Ala Leu Val 
465                 470                 475                 480 


Ala Val Val Gly Ala Ala Leu Val Gln Leu Phe Trp Leu Gln Asp 
                485                 490                 495 


<210>  4772
<211>  495
<212>  PRT
<213>  Homo Sapiens

<400>  4772

Met Gly Leu Ser Arg Lys Glu Gln Val Phe Leu Ala Leu Leu Gly Ala 
1               5                   10                  15      


Ser Gly Val Ser Gly Leu Thr Ala Leu Ile Leu Leu Leu Val Glu Ala 
            20                  25                  30          


Thr Ser Val Leu Leu Pro Thr Asp Ile Lys Phe Gly Ile Val Phe Asp 
        35                  40                  45              


Ala Gly Ser Ser His Thr Ser Leu Phe Leu Tyr Gln Trp Leu Ala Asn 
    50                  55                  60                  


Lys Glu Asn Gly Thr Gly Val Val Ser Gln Ala Leu Ala Cys Gln Val 
65                  70                  75                  80  


Glu Gly Pro Gly Ile Ser Ser Tyr Thr Ser Asn Ala Ala Gln Ala Gly 
                85                  90                  95      


Glu Ser Leu Gln Gly Cys Leu Glu Glu Ala Leu Val Leu Ile Pro Glu 
            100                 105                 110         


Ala Gln His Arg Lys Thr Pro Thr Phe Leu Gly Ala Thr Ala Gly Met 
        115                 120                 125             


Arg Leu Leu Ser Arg Lys Asn Ser Ser Gln Ala Arg Asp Ile Phe Ala 
    130                 135                 140                 


Ala Val Thr Gln Val Leu Gly Arg Ser Pro Val Asp Phe Trp Gly Ala 
145                 150                 155                 160 


Glu Leu Leu Ala Gly Gln Ala Glu Gly Ala Phe Gly Trp Ile Thr Val 
                165                 170                 175     


Asn Tyr Gly Leu Gly Thr Leu Val Lys Tyr Ser Phe Thr Gly Glu Trp 
            180                 185                 190         


Ile Gln Pro Pro Glu Glu Met Leu Val Gly Ala Leu Asp Met Gly Gly 
        195                 200                 205             


Ala Ser Thr Gln Ile Thr Phe Val Pro Gly Gly Pro Ile Leu Asp Lys 
    210                 215                 220                 


Ser Thr Gln Ala Asp Phe Arg Leu Tyr Gly Ser Asp Tyr Ser Val Tyr 
225                 230                 235                 240 


Thr His Ser Tyr Leu Cys Phe Gly Arg Asp Gln Met Leu Ser Arg Leu 
                245                 250                 255     


Leu Val Gly Leu Val Gln Ser Arg Pro Ala Ala Leu Leu Arg His Pro 
            260                 265                 270         


Cys Tyr Leu Ser Gly Tyr Gln Thr Thr Leu Ala Leu Gly Pro Leu Tyr 
        275                 280                 285             


Glu Ser Pro Cys Val His Ala Thr Pro Pro Leu Ser Leu Pro Gln Asn 
    290                 295                 300                 


Leu Thr Val Glu Gly Thr Gly Asn Pro Gly Ala Cys Val Ser Ala Ile 
305                 310                 315                 320 


Arg Glu Leu Phe Asn Phe Ser Ser Cys Gln Gly Gln Glu Asp Cys Ala 
                325                 330                 335     


Phe Asp Gly Val Tyr Gln Pro Pro Leu Arg Gly Gln Phe Tyr Ala Phe 
            340                 345                 350         


Ser Asn Phe Tyr Tyr Thr Phe His Phe Leu Asn Leu Thr Ser Arg Gln 
        355                 360                 365             


Pro Leu Ser Thr Val Asn Ala Thr Ile Trp Glu Phe Cys Gln Arg Pro 
    370                 375                 380                 


Trp Lys Leu Val Glu Ala Ser Tyr Pro Gly Gln Asp Arg Trp Leu Arg 
385                 390                 395                 400 


Asp Tyr Cys Ala Ser Gly Leu Tyr Ile Leu Thr Leu Leu His Glu Gly 
                405                 410                 415     


Tyr Gly Phe Ser Glu Glu Thr Trp Pro Ser Leu Glu Phe Arg Lys Gln 
            420                 425                 430         


Ala Gly Gly Val Asp Ile Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu 
        435                 440                 445             


Thr Gly Met Ile Pro Ala Asp Ala Pro Ala Gln Trp Arg Ala Glu Ser 
    450                 455                 460                 


Tyr Gly Val Trp Val Ala Lys Val Val Phe Met Val Leu Ala Leu Val 
465                 470                 475                 480 


Ala Val Val Gly Ala Ala Leu Val Gln Leu Phe Trp Leu Gln Asp 
                485                 490                 495 


<210>  4773
<211>  135
<212>  PRT
<213>  Homo Sapiens

<400>  4773

Met Ile Ser Ala His Cys Asn Leu Cys Leu Leu Asp Ser Ser Asp Ser 
1               5                   10                  15      


Cys Ala Leu Ala Ser Gln Val Ala Gly Ile Thr Gly Val His His His 
            20                  25                  30          


Ala Gln Leu Ile Phe Val Phe Leu Ile Glu Thr Glu Phe His His Val 
        35                  40                  45              


Gly Gln Ala Gly Leu Glu Leu Trp Val Gln Glu Ile Leu Pro Pro Cys 
    50                  55                  60                  


Leu Pro Lys Cys Trp Asp Tyr Arg Cys Glu Pro Pro Arg Met Ala Leu 
65                  70                  75                  80  


Asn Phe Leu Phe Leu Gly Ile Pro Lys Phe Ser Thr Phe Ser Ala Leu 
                85                  90                  95      


Glu Phe Val Asn Ile Phe Val Glu Tyr His Met Thr Val Ile Pro Glu 
            100                 105                 110         


Cys Ser Asn Leu Phe Met Ile Tyr Leu Gly Lys Phe Thr Thr Val Leu 
        115                 120                 125             


Leu Phe Ala Ile Ile Trp Leu 
    130                 135 


<210>  4774
<211>  124
<212>  PRT
<213>  Homo Sapiens

<400>  4774

Met Leu Met Leu Phe Val Phe Gly Val Leu Leu His Glu Val Ser Leu 
1               5                   10                  15      


Ser Gly Gln Asn Glu Ala Pro Pro Asn Thr His Ser Ile Pro Gly Glu 
            20                  25                  30          


Pro Leu Tyr Asn Tyr Ala Ser Ile Arg Leu Pro Glu Glu His Ile Pro 
        35                  40                  45              


Phe Phe Leu His Asn Asn Arg His Ile Ala Thr Val Cys Arg Lys Asp 
    50                  55                  60                  


Ser Leu Cys Pro Tyr Lys Lys His Leu Glu Lys Leu Lys Tyr Cys Trp 
65                  70                  75                  80  


Gly Tyr Glu Lys Ser Cys Lys Pro Glu Phe Arg Phe Gly Tyr Pro Val 
                85                  90                  95      


Cys Ser Tyr Val Asp Met Gly Trp Thr Asp Thr Leu Glu Ser Ala Glu 
            100                 105                 110         


Asp Ile Phe Trp Lys Gln Ala Asp Phe Gly Tyr Ala 
        115                 120                 


<210>  4775
<211>  132
<212>  PRT
<213>  Homo Sapiens

<400>  4775

Met Leu Met Leu Phe Val Phe Gly Val Leu Leu His Glu Val Ser Leu 
1               5                   10                  15      


Ser Gly Gln Asn Glu Ala Pro Pro Asn Thr His Ser Ile Pro Gly Glu 
            20                  25                  30          


Pro Leu Tyr Asn Tyr Ala Ser Ile Arg Leu Pro Glu Glu His Ile Pro 
        35                  40                  45              


Phe Phe Leu His Asn Asn Arg His Ile Ala Thr Val Cys Arg Lys Asp 
    50                  55                  60                  


Ser Leu Cys Pro Tyr Lys Lys His Leu Glu Lys Leu Lys Tyr Cys Trp 
65                  70                  75                  80  


Gly Tyr Glu Lys Ser Cys Lys Pro Glu Phe Arg Phe Gly Tyr Pro Val 
                85                  90                  95      


Cys Ser Tyr Val Asp Met Gly Trp Thr Asp Thr Leu Glu Ser Ala Glu 
            100                 105                 110         


Asp Ile Phe Trp Lys Gln Ala Asp Phe Gly Tyr Ala Arg Glu Arg Leu 
        115                 120                 125             


Glu Glu Met His 
    130         


<210>  4776
<211>  206
<212>  PRT
<213>  Homo Sapiens

<400>  4776

Met Leu Met Leu Phe Val Phe Gly Val Leu Leu His Glu Val Ser Leu 
1               5                   10                  15      


Ser Gly Gln Asn Glu Ala Pro Pro Asn Thr His Ser Ile Pro Gly Glu 
            20                  25                  30          


Pro Leu Tyr Asn Tyr Ala Ser Ile Arg Leu Pro Glu Glu His Ile Pro 
        35                  40                  45              


Phe Phe Leu His Asn Asn Arg His Ile Ala Thr Val Cys Arg Lys Asp 
    50                  55                  60                  


Ser Leu Cys Pro Tyr Lys Lys His Leu Glu Lys Leu Lys Tyr Cys Trp 
65                  70                  75                  80  


Gly Tyr Glu Lys Ser Cys Lys Pro Glu Phe Arg Phe Gly Tyr Pro Val 
                85                  90                  95      


Cys Ser Tyr Val Asp Met Gly Trp Thr Asp Thr Leu Glu Ser Ala Glu 
            100                 105                 110         


Asp Ile Phe Trp Lys Gln Ala Asp Phe Gly Tyr Ala Arg Glu Arg Leu 
        115                 120                 125             


Glu Glu Met His Val Leu Cys Gln Pro Lys Glu Thr Ser Asp Ser Ser 
    130                 135                 140                 


Leu Val Cys Ser Arg Tyr Leu Gln Tyr Cys Arg Ala Thr Asn Leu Tyr 
145                 150                 155                 160 


Leu Asp Leu Arg Asn Ile Lys Arg Asn His Asp Arg Phe Lys Glu Asp 
                165                 170                 175     


Phe Phe Gln Ser Gly Glu Ile Gly Gly His Cys Lys Leu Asp Ile Arg 
            180                 185                 190         


Thr Leu Thr Ser Glu Gly Gln Arg Lys Ser Pro Leu Gln Ser 
        195                 200                 205     


<210>  4777
<211>  443
<212>  PRT
<213>  Homo Sapiens

<400>  4777

Met Leu Met Leu Phe Val Phe Gly Val Leu Leu His Glu Val Ser Leu 
1               5                   10                  15      


Ser Gly Gln Asn Glu Ala Pro Pro Asn Thr His Ser Ile Pro Gly Glu 
            20                  25                  30          


Pro Leu Tyr Asn Tyr Ala Ser Ile Arg Leu Pro Glu Glu His Ile Pro 
        35                  40                  45              


Phe Phe Leu His Asn Asn Arg His Ile Ala Thr Val Cys Arg Lys Asp 
    50                  55                  60                  


Ser Leu Cys Pro Tyr Lys Lys His Leu Glu Lys Leu Lys Tyr Cys Trp 
65                  70                  75                  80  


Gly Tyr Glu Lys Ser Cys Lys Pro Glu Phe Arg Phe Gly Tyr Pro Val 
                85                  90                  95      


Cys Ser Tyr Val Asp Met Gly Trp Thr Asp Thr Leu Glu Ser Ala Glu 
            100                 105                 110         


Asp Ile Phe Trp Lys Gln Ala Asp Phe Gly Tyr Ala Arg Glu Arg Leu 
        115                 120                 125             


Glu Glu Met His Val Leu Cys Gln Pro Lys Glu Thr Ser Asp Ser Ser 
    130                 135                 140                 


Leu Val Cys Ser Arg Tyr Leu Gln Tyr Cys Arg Ala Thr Asn Leu Tyr 
145                 150                 155                 160 


Leu Asp Leu Arg Asn Ile Lys Arg Asn His Asp Arg Phe Lys Glu Asp 
                165                 170                 175     


Phe Phe Gln Ser Gly Glu Ile Gly Gly His Cys Lys Leu Asp Ile Arg 
            180                 185                 190         


Thr Leu Thr Ser Glu Gly Gln Arg Lys Ser Pro Leu Gln Ser Trp Phe 
        195                 200                 205             


Ala Glu Leu Gln Ser Tyr Thr Gln Leu Asn Phe Arg Pro Ile Glu Asp 
    210                 215                 220                 


Ala Lys Cys Asp Ile Val Ile Glu Lys Pro Thr Tyr Phe Met Lys Leu 
225                 230                 235                 240 


Asp Ala Gly Val Asn Met Tyr His His Phe Cys Asp Phe Ile Asn Leu 
                245                 250                 255     


Tyr Ile Thr Gln His Val Asn Asn Ser Phe Ser Thr Asp Val Tyr Ile 
            260                 265                 270         


Val Met Trp Asp Thr Asp Gly Lys Ile Arg Val Thr Ile Leu Ala Arg 
        275                 280                 285             


Ser Thr Glu Tyr Arg Lys Ile Leu Asn Gln Asn Glu Leu Val Asn Ala 
    290                 295                 300                 


Leu Lys Thr Val Ser Thr Phe Glu Val Gln Ile Val Asp Tyr Lys Tyr 
305                 310                 315                 320 


Arg Glu Leu Gly Phe Leu Asp Gln Leu Arg Ile Thr His Asn Thr Asp 
                325                 330                 335     


Ile Phe Ile Gly Met His Gly Ala Gly Leu Thr His Leu Leu Phe Leu 
            340                 345                 350         


Pro Asp Trp Ala Ala Val Phe Glu Leu Tyr Asn Cys Glu Asp Glu Arg 
        355                 360                 365             


Cys Tyr Leu Asp Leu Ala Arg Leu Arg Gly Val His Tyr Ile Thr Trp 
    370                 375                 380                 


Arg Arg Gln Asn Lys Val Phe Pro Gln Asp Lys Gly His His Pro Thr 
385                 390                 395                 400 


Leu Gly Glu His Pro Lys Phe Thr Asn Tyr Ser Phe Asp Val Glu Glu 
                405                 410                 415     


Phe Met Tyr Leu Val Leu Gln Ala Ala Asp His Val Leu Gln His Pro 
            420                 425                 430         


Lys Trp Pro Phe Lys Lys Lys His Asp Glu Leu 
        435                 440             


<210>  4778
<211>  527
<212>  PRT
<213>  Homo Sapiens

<400>  4778

Met Leu Met Leu Phe Val Phe Gly Val Leu Leu His Glu Val Ser Leu 
1               5                   10                  15      


Ser Gly Gln Asn Glu Ala Pro Pro Asn Thr His Ser Ile Pro Gly Glu 
            20                  25                  30          


Pro Leu Tyr Asn Tyr Ala Ser Ile Arg Leu Pro Glu Glu His Ile Pro 
        35                  40                  45              


Phe Phe Leu His Asn Asn Arg His Ile Ala Thr Val Cys Arg Lys Asp 
    50                  55                  60                  


Ser Leu Cys Pro Tyr Lys Lys His Leu Glu Lys Leu Lys Tyr Cys Trp 
65                  70                  75                  80  


Gly Tyr Glu Lys Ser Cys Lys Pro Glu Phe Arg Phe Gly Tyr Pro Val 
                85                  90                  95      


Cys Ser Tyr Val Asp Met Gly Trp Thr Asp Thr Leu Glu Ser Ala Glu 
            100                 105                 110         


Asp Ile Phe Trp Lys Gln Ala Asp Phe Gly Tyr Ala Arg Glu Arg Leu 
        115                 120                 125             


Glu Glu Met His Val Leu Cys Gln Pro Lys Glu Thr Ser Asp Ser Ser 
    130                 135                 140                 


Leu Val Cys Ser Arg Tyr Leu Gln Tyr Cys Arg Ala Thr Asn Leu Tyr 
145                 150                 155                 160 


Leu Asp Leu Arg Asn Ile Lys Arg Asn His Asp Arg Phe Lys Glu Asp 
                165                 170                 175     


Phe Phe Gln Ser Gly Glu Ile Gly Gly His Cys Lys Leu Asp Ile Arg 
            180                 185                 190         


Thr Leu Thr Ser Glu Gly Gln Arg Lys Ser Pro Leu Gln Ser Trp Phe 
        195                 200                 205             


Ala Glu Leu Gln Ser Tyr Thr Gln Leu Asn Phe Arg Pro Ile Glu Asp 
    210                 215                 220                 


Ala Lys Cys Asp Ile Val Ile Glu Lys Pro Thr Tyr Phe Met Lys Leu 
225                 230                 235                 240 


Asp Ala Gly Val Asn Met Tyr His His Phe Cys Asp Phe Ile Asn Leu 
                245                 250                 255     


Tyr Ile Thr Gln His Val Asn Asn Ser Phe Ser Thr Asp Val Tyr Ile 
            260                 265                 270         


Val Met Trp Asp Thr Ser Ser Tyr Gly Tyr Gly Asp Leu Phe Ser Asp 
        275                 280                 285             


Thr Trp Asn Ala Phe Thr Asp Tyr Asp Val Ile His Leu Lys Thr Tyr 
    290                 295                 300                 


Asp Ser Lys Arg Val Cys Phe Lys Glu Ala Val Phe Ser Leu Leu Pro 
305                 310                 315                 320 


Arg Met Arg Tyr Gly Leu Phe Tyr Asn Thr Pro Leu Ile Ser Gly Cys 
                325                 330                 335     


Gln Asn Thr Gly Leu Phe Arg Ala Phe Ala Gln His Val Leu His Arg 
            340                 345                 350         


Leu Asn Ile Thr Gln Glu Gly Pro Lys Asp Gly Lys Ile Arg Val Thr 
        355                 360                 365             


Ile Leu Ala Arg Ser Thr Glu Tyr Arg Lys Ile Leu Asn Gln Asn Glu 
    370                 375                 380                 


Leu Val Asn Ala Leu Lys Thr Val Ser Thr Phe Glu Val Gln Ile Val 
385                 390                 395                 400 


Asp Tyr Lys Tyr Arg Glu Leu Gly Phe Leu Asp Gln Leu Arg Ile Thr 
                405                 410                 415     


His Asn Thr Asp Ile Phe Ile Gly Met His Gly Ala Gly Leu Thr His 
            420                 425                 430         


Leu Leu Phe Leu Pro Asp Trp Ala Ala Val Phe Glu Leu Tyr Asn Cys 
        435                 440                 445             


Glu Asp Glu Arg Cys Tyr Leu Asp Leu Ala Arg Leu Arg Gly Val His 
    450                 455                 460                 


Tyr Ile Thr Trp Arg Arg Gln Asn Lys Val Phe Pro Gln Asp Lys Gly 
465                 470                 475                 480 


His His Pro Thr Leu Gly Glu His Pro Lys Phe Thr Asn Tyr Ser Phe 
                485                 490                 495     


Asp Val Glu Glu Phe Met Tyr Leu Val Leu Gln Ala Ala Asp His Val 
            500                 505                 510         


Leu Gln His Pro Lys Trp Pro Phe Lys Lys Lys His Asp Glu Leu 
        515                 520                 525         


<210>  4779
<211>  443
<212>  PRT
<213>  Homo Sapiens

<400>  4779

Met Leu Met Leu Phe Val Phe Gly Val Leu Leu His Glu Val Ser Leu 
1               5                   10                  15      


Ser Gly Gln Asn Glu Ala Pro Pro Asn Thr His Ser Ile Pro Gly Glu 
            20                  25                  30          


Pro Leu Tyr Asn Tyr Ala Ser Ile Arg Leu Pro Glu Glu His Ile Pro 
        35                  40                  45              


Phe Phe Leu His Asn Asn Arg His Ile Ala Thr Val Cys Arg Lys Asp 
    50                  55                  60                  


Ser Leu Cys Pro Tyr Lys Lys His Leu Glu Lys Leu Lys Tyr Cys Trp 
65                  70                  75                  80  


Gly Tyr Glu Lys Ser Cys Lys Pro Glu Phe Arg Phe Gly Tyr Pro Val 
                85                  90                  95      


Cys Ser Tyr Val Asp Met Gly Trp Thr Asp Thr Leu Glu Ser Ala Glu 
            100                 105                 110         


Asp Ile Phe Trp Lys Gln Ala Asp Phe Gly Tyr Ala Arg Glu Arg Leu 
        115                 120                 125             


Glu Glu Met His Val Leu Cys Gln Pro Lys Glu Thr Ser Asp Ser Ser 
    130                 135                 140                 


Leu Val Cys Ser Arg Tyr Leu Gln Tyr Cys Arg Ala Thr Asn Leu Tyr 
145                 150                 155                 160 


Leu Asp Leu Arg Asn Ile Lys Arg Asn His Asp Arg Phe Lys Glu Asp 
                165                 170                 175     


Phe Phe Gln Ser Gly Glu Ile Gly Gly His Cys Lys Leu Asp Ile Arg 
            180                 185                 190         


Thr Leu Thr Ser Glu Gly Gln Arg Lys Ser Pro Leu Gln Ser Trp Phe 
        195                 200                 205             


Ala Glu Leu Gln Ser Tyr Thr Gln Leu Asn Phe Arg Pro Ile Glu Asp 
    210                 215                 220                 


Ala Lys Cys Asp Ile Val Ile Glu Lys Pro Thr Tyr Phe Met Lys Leu 
225                 230                 235                 240 


Asp Ala Gly Val Asn Met Tyr His His Phe Cys Asp Phe Ile Asn Leu 
                245                 250                 255     


Tyr Ile Thr Gln His Val Asn Asn Ser Phe Ser Thr Asp Val Tyr Ile 
            260                 265                 270         


Val Met Trp Asp Thr Asp Gly Lys Ile Arg Val Thr Ile Leu Ala Arg 
        275                 280                 285             


Ser Thr Glu Tyr Arg Lys Ile Leu Asn Gln Asn Glu Leu Val Asn Ala 
    290                 295                 300                 


Leu Lys Thr Val Ser Thr Phe Glu Val Gln Ile Val Asp Tyr Lys Tyr 
305                 310                 315                 320 


Arg Glu Leu Gly Phe Leu Asp Gln Leu Arg Ile Thr His Asn Thr Asp 
                325                 330                 335     


Ile Phe Ile Gly Met His Gly Ala Gly Leu Thr His Leu Leu Phe Leu 
            340                 345                 350         


Pro Asp Trp Ala Ala Val Phe Glu Leu Tyr Asn Cys Glu Asp Glu Arg 
        355                 360                 365             


Cys Tyr Leu Asp Leu Ala Arg Leu Arg Gly Val His Tyr Ile Thr Trp 
    370                 375                 380                 


Arg Arg Gln Asn Lys Val Phe Pro Gln Asp Lys Gly His His Pro Thr 
385                 390                 395                 400 


Leu Gly Glu His Pro Lys Phe Thr Asn Tyr Ser Phe Asp Val Glu Glu 
                405                 410                 415     


Phe Met Tyr Leu Val Leu Gln Ala Ala Asp His Val Leu Gln His Pro 
            420                 425                 430         


Lys Trp Pro Phe Lys Lys Lys His Asp Glu Leu 
        435                 440             


<210>  4780
<211>  527
<212>  PRT
<213>  Homo Sapiens

<400>  4780

Met Leu Met Leu Phe Val Phe Gly Val Leu Leu His Glu Val Ser Leu 
1               5                   10                  15      


Ser Gly Gln Asn Glu Ala Pro Pro Asn Thr His Ser Ile Pro Gly Glu 
            20                  25                  30          


Pro Leu Tyr Asn Tyr Ala Ser Ile Arg Leu Pro Glu Glu His Ile Pro 
        35                  40                  45              


Phe Phe Leu His Asn Asn Arg His Ile Ala Thr Val Cys Arg Lys Asp 
    50                  55                  60                  


Ser Leu Cys Pro Tyr Lys Lys His Leu Glu Lys Leu Lys Tyr Cys Trp 
65                  70                  75                  80  


Gly Tyr Glu Lys Ser Cys Lys Pro Glu Phe Arg Phe Gly Tyr Pro Val 
                85                  90                  95      


Cys Ser Tyr Val Asp Met Gly Trp Thr Asp Thr Leu Glu Ser Ala Glu 
            100                 105                 110         


Asp Ile Phe Trp Lys Gln Ala Asp Phe Gly Tyr Ala Arg Glu Arg Leu 
        115                 120                 125             


Glu Glu Met His Val Leu Cys Gln Pro Lys Glu Thr Ser Asp Ser Ser 
    130                 135                 140                 


Leu Val Cys Ser Arg Tyr Leu Gln Tyr Cys Arg Ala Thr Asn Leu Tyr 
145                 150                 155                 160 


Leu Asp Leu Arg Asn Ile Lys Arg Asn His Asp Arg Phe Lys Glu Asp 
                165                 170                 175     


Phe Phe Gln Ser Gly Glu Ile Gly Gly His Cys Lys Leu Asp Ile Arg 
            180                 185                 190         


Thr Leu Thr Ser Glu Gly Gln Arg Lys Ser Pro Leu Gln Ser Trp Phe 
        195                 200                 205             


Ala Glu Leu Gln Ser Tyr Thr Gln Leu Asn Phe Arg Pro Ile Glu Asp 
    210                 215                 220                 


Ala Lys Cys Asp Ile Val Ile Glu Lys Pro Thr Tyr Phe Met Lys Leu 
225                 230                 235                 240 


Asp Ala Gly Val Asn Met Tyr His His Phe Cys Asp Phe Ile Asn Leu 
                245                 250                 255     


Tyr Ile Thr Gln His Val Asn Asn Ser Phe Ser Thr Asp Val Tyr Ile 
            260                 265                 270         


Val Met Trp Asp Thr Ser Ser Tyr Gly Tyr Gly Asp Leu Phe Ser Asp 
        275                 280                 285             


Thr Trp Asn Ala Phe Thr Asp Tyr Asp Val Ile His Leu Lys Thr Tyr 
    290                 295                 300                 


Asp Ser Lys Arg Val Cys Phe Lys Glu Ala Val Phe Ser Leu Leu Pro 
305                 310                 315                 320 


Arg Met Arg Tyr Gly Leu Phe Tyr Asn Thr Pro Leu Ile Ser Gly Cys 
                325                 330                 335     


Gln Asn Thr Gly Leu Phe Arg Ala Phe Ala Gln His Val Leu His Arg 
            340                 345                 350         


Leu Asn Ile Thr Gln Glu Gly Pro Lys Asp Gly Lys Ile Arg Val Thr 
        355                 360                 365             


Ile Leu Ala Arg Ser Thr Glu Tyr Arg Lys Ile Leu Asn Gln Asn Glu 
    370                 375                 380                 


Leu Val Asn Ala Leu Lys Thr Val Ser Thr Phe Glu Val Gln Ile Val 
385                 390                 395                 400 


Asp Tyr Lys Tyr Arg Glu Leu Gly Phe Leu Asp Gln Leu Arg Ile Thr 
                405                 410                 415     


His Asn Thr Asp Ile Phe Ile Gly Met His Gly Ala Gly Leu Thr His 
            420                 425                 430         


Leu Leu Phe Leu Pro Asp Trp Ala Ala Val Phe Glu Leu Tyr Asn Cys 
        435                 440                 445             


Glu Asp Glu Arg Cys Tyr Leu Asp Leu Ala Arg Leu Arg Gly Val His 
    450                 455                 460                 


Tyr Ile Thr Trp Arg Arg Gln Asn Lys Val Phe Pro Gln Asp Lys Gly 
465                 470                 475                 480 


His His Pro Thr Leu Gly Glu His Pro Lys Phe Thr Asn Tyr Ser Phe 
                485                 490                 495     


Asp Val Glu Glu Phe Met Tyr Leu Val Leu Gln Ala Ala Asp His Val 
            500                 505                 510         


Leu Gln His Pro Lys Trp Pro Phe Lys Lys Lys His Asp Glu Leu 
        515                 520                 525         


<210>  4781
<211>  314
<212>  PRT
<213>  Homo Sapiens

<400>  4781

Met Ala Pro Pro Gln Val Leu Ala Phe Gly Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Thr Ala Thr Phe Ala Ala Ala Gln Glu Glu Cys Val Cys Glu Asn Tyr 
            20                  25                  30          


Lys Leu Ala Val Asn Cys Phe Val Asn Asn Asn Arg Gln Cys Gln Cys 
        35                  40                  45              


Thr Ser Val Gly Ala Gln Asn Thr Val Ile Cys Ser Lys Leu Ala Ala 
    50                  55                  60                  


Lys Cys Leu Val Met Lys Ala Glu Met Asn Gly Ser Lys Leu Gly Arg 
65                  70                  75                  80  


Arg Ala Lys Pro Glu Gly Ala Leu Gln Asn Asn Asp Gly Leu Tyr Asp 
                85                  90                  95      


Pro Asp Cys Asp Glu Ser Gly Leu Phe Lys Ala Lys Gln Cys Asn Gly 
            100                 105                 110         


Thr Ser Met Cys Trp Cys Val Asn Thr Ala Gly Val Arg Arg Thr Asp 
        115                 120                 125             


Lys Asp Thr Glu Ile Thr Cys Ser Glu Arg Val Arg Thr Tyr Trp Ile 
    130                 135                 140                 


Ile Ile Glu Leu Lys His Lys Ala Arg Glu Lys Pro Tyr Asp Ser Lys 
145                 150                 155                 160 


Ser Leu Arg Thr Ala Leu Gln Lys Glu Ile Thr Thr Arg Tyr Gln Leu 
                165                 170                 175     


Asp Pro Lys Phe Ile Thr Ser Ile Leu Tyr Glu Asn Asn Val Ile Thr 
            180                 185                 190         


Ile Asp Leu Val Gln Asn Ser Ser Gln Lys Thr Gln Asn Asp Val Asp 
        195                 200                 205             


Ile Ala Asp Val Ala Tyr Tyr Phe Glu Lys Asp Val Lys Gly Glu Ser 
    210                 215                 220                 


Leu Phe His Ser Lys Lys Met Asp Leu Thr Val Asn Gly Glu Gln Leu 
225                 230                 235                 240 


Asp Leu Asp Pro Gly Gln Thr Leu Ile Tyr Tyr Val Asp Glu Lys Ala 
                245                 250                 255     


Pro Glu Phe Ser Met Gln Gly Leu Lys Ala Gly Val Ile Ala Val Ile 
            260                 265                 270         


Val Val Val Val Ile Ala Val Val Ala Gly Ile Val Val Leu Val Ile 
        275                 280                 285             


Ser Arg Lys Lys Arg Met Ala Lys Tyr Glu Lys Ala Glu Ile Lys Glu 
    290                 295                 300                 


Met Gly Glu Met His Arg Glu Leu Asn Ala 
305                 310                 


<210>  4782
<211>  199
<212>  PRT
<213>  Homo Sapiens

<400>  4782

Met Ala Pro Pro Gln Val Leu Ala Phe Gly Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Thr Ala Thr Phe Ala Ala Ala Gln Glu Gly Glu Ala Arg Ile Gly Ala 
            20                  25                  30          


Glu Leu Trp Ser Trp Ala Gly Leu Gly Gly Ser Gly Pro Arg Pro Ser 
        35                  40                  45              


Ala Pro Glu Thr Gly Ile Ile Gly Arg Gly Pro Arg Gly Arg Ala Phe 
    50                  55                  60                  


Gln Arg Gly Asp Arg Thr Val Arg Pro Cys Ser Gly Ser Gly Pro Pro 
65                  70                  75                  80  


Arg Gly Arg Lys Arg Arg Gly Pro Ser Arg Gly Ala Ala Ser Leu Arg 
                85                  90                  95      


Ser Phe Ala Arg Leu Glu Cys Val Cys Glu Asn Tyr Lys Leu Ala Val 
            100                 105                 110         


Asn Cys Phe Val Asn Asn Asn Arg Gln Cys Gln Cys Thr Ser Val Gly 
        115                 120                 125             


Ala Gln Asn Thr Val Ile Cys Ser Lys Leu Ala Ala Lys Cys Leu Val 
    130                 135                 140                 


Met Lys Ala Glu Met Asn Gly Ser Lys Leu Gly Arg Arg Ala Lys Pro 
145                 150                 155                 160 


Glu Gly Ala Leu Gln Asn Asn Asp Gly Leu Tyr Asp Pro Asp Cys Asp 
                165                 170                 175     


Glu Ser Gly Leu Phe Lys Ala Lys Gln Cys Asn Gly Thr Ser Met Cys 
            180                 185                 190         


Trp Cys Val Asn Thr Ala Gly 
        195                 


<210>  4783
<211>  342
<212>  PRT
<213>  Homo Sapiens

<400>  4783

Met Glu Thr Lys His Leu Gly Arg Gly Gly Ala Gly Arg Ala Gly Pro 
1               5                   10                  15      


His Leu Trp Arg Gly Pro Arg Pro Asn Cys Ser Ala Gly Ala Gly Gly 
            20                  25                  30          


Gly Glu Pro Thr His Ser Pro Asn Ser Arg Ala Val Thr His Gln Arg 
        35                  40                  45              


Ala Pro Ala Ala Arg Glu Cys Val Cys Glu Asn Tyr Lys Leu Ala Val 
    50                  55                  60                  


Asn Cys Phe Val Asn Asn Asn Arg Gln Cys Gln Cys Thr Ser Val Gly 
65                  70                  75                  80  


Ala Gln Asn Thr Val Ile Cys Ser Lys Leu Ala Ala Lys Cys Leu Val 
                85                  90                  95      


Met Lys Ala Glu Met Asn Gly Ser Lys Leu Gly Arg Arg Ala Lys Pro 
            100                 105                 110         


Glu Gly Ala Leu Gln Asn Asn Asp Gly Leu Tyr Asp Pro Asp Cys Asp 
        115                 120                 125             


Glu Ser Gly Leu Phe Lys Ala Lys Gln Cys Asn Gly Thr Ser Met Cys 
    130                 135                 140                 


Trp Cys Val Asn Thr Ala Gly Val Arg Arg Thr Asp Lys Asp Thr Glu 
145                 150                 155                 160 


Ile Thr Cys Ser Glu Arg Val Arg Thr Tyr Trp Ile Ile Ile Glu Leu 
                165                 170                 175     


Lys His Lys Ala Arg Glu Lys Pro Tyr Asp Ser Lys Ser Leu Arg Thr 
            180                 185                 190         


Ala Leu Gln Lys Glu Ile Thr Thr Arg Tyr Gln Leu Asp Pro Lys Phe 
        195                 200                 205             


Ile Thr Ser Ile Leu Tyr Glu Asn Asn Val Ile Thr Ile Asp Leu Val 
    210                 215                 220                 


Gln Asn Ser Ser Gln Lys Thr Gln Asn Asp Val Asp Ile Ala Asp Val 
225                 230                 235                 240 


Ala Tyr Tyr Phe Glu Lys Asp Val Lys Gly Glu Ser Leu Phe His Ser 
                245                 250                 255     


Lys Lys Met Asp Leu Thr Val Asn Gly Glu Gln Leu Asp Leu Asp Pro 
            260                 265                 270         


Gly Gln Thr Leu Ile Tyr Tyr Val Asp Glu Lys Ala Pro Glu Phe Ser 
        275                 280                 285             


Met Gln Gly Leu Lys Ala Gly Val Ile Ala Val Ile Val Val Val Val 
    290                 295                 300                 


Ile Ala Val Val Ala Gly Ile Val Val Leu Val Ile Ser Arg Lys Lys 
305                 310                 315                 320 


Arg Met Ala Lys Tyr Glu Lys Ala Glu Ile Lys Glu Met Gly Glu Met 
                325                 330                 335     


His Arg Glu Leu Asn Ala 
            340         


<210>  4784
<211>  342
<212>  PRT
<213>  Homo Sapiens

<400>  4784

Met Glu Thr Lys His Leu Gly Arg Gly Gly Ala Gly Arg Ala Gly Pro 
1               5                   10                  15      


His Leu Trp Arg Gly Pro Arg Pro Asn Cys Ser Ala Gly Ala Gly Gly 
            20                  25                  30          


Gly Glu Pro Thr His Ser Pro Asn Ser Arg Ala Val Thr His Gln Arg 
        35                  40                  45              


Ala Pro Ala Ala Arg Glu Cys Val Cys Glu Asn Tyr Lys Leu Ala Val 
    50                  55                  60                  


Asn Cys Phe Val Asn Asn Asn Arg Gln Cys Gln Cys Thr Ser Val Gly 
65                  70                  75                  80  


Ala Gln Asn Thr Val Ile Cys Ser Lys Leu Ala Ala Lys Cys Leu Val 
                85                  90                  95      


Met Lys Ala Glu Met Asn Gly Ser Lys Leu Gly Arg Arg Ala Lys Pro 
            100                 105                 110         


Glu Gly Ala Leu Gln Asn Asn Asp Gly Leu Tyr Asp Pro Asp Cys Asp 
        115                 120                 125             


Glu Ser Gly Leu Phe Lys Ala Lys Gln Cys Asn Gly Thr Ser Met Cys 
    130                 135                 140                 


Trp Cys Val Asn Thr Ala Gly Val Arg Arg Thr Asp Lys Asp Thr Glu 
145                 150                 155                 160 


Ile Thr Cys Ser Glu Arg Val Arg Thr Tyr Trp Ile Ile Ile Glu Leu 
                165                 170                 175     


Lys His Lys Ala Arg Glu Lys Pro Tyr Asp Ser Lys Ser Leu Arg Thr 
            180                 185                 190         


Ala Leu Gln Lys Glu Ile Thr Thr Arg Tyr Gln Leu Asp Pro Lys Phe 
        195                 200                 205             


Ile Thr Ser Ile Leu Tyr Glu Asn Asn Val Ile Thr Ile Asp Leu Val 
    210                 215                 220                 


Gln Asn Ser Ser Gln Lys Thr Gln Asn Asp Val Asp Ile Ala Asp Val 
225                 230                 235                 240 


Ala Tyr Tyr Phe Glu Lys Asp Val Lys Gly Glu Ser Leu Phe His Ser 
                245                 250                 255     


Lys Lys Met Asp Leu Thr Val Asn Gly Glu Gln Leu Asp Leu Asp Pro 
            260                 265                 270         


Gly Gln Thr Leu Ile Tyr Tyr Val Asp Glu Lys Ala Pro Glu Phe Ser 
        275                 280                 285             


Met Gln Gly Leu Lys Ala Gly Val Ile Ala Val Ile Val Val Val Val 
    290                 295                 300                 


Ile Ala Val Val Ala Gly Ile Val Val Leu Val Ile Ser Arg Lys Lys 
305                 310                 315                 320 


Arg Met Ala Lys Tyr Glu Lys Ala Glu Ile Lys Glu Met Gly Glu Met 
                325                 330                 335     


His Arg Glu Leu Asn Ala 
            340         


<210>  4785
<211>  122
<212>  PRT
<213>  Homo Sapiens

<400>  4785

Met Phe Gln Ile Asp Gln Ala Thr Lys Gln Cys Ser Lys Met Thr Leu 
1               5                   10                  15      


Thr Gln Pro Trp Asp Pro Leu Asp Ile Pro Gln Asn Ser Thr Phe Glu 
            20                  25                  30          


Asp Gln Tyr Ser Ile Gly Gly Pro Gln Glu Gln Ile Thr Val Gln Glu 
        35                  40                  45              


Trp Ser Asp Arg Lys Ser Ala Arg Ser Tyr Glu Thr Trp Ile Gly Ile 
    50                  55                  60                  


Tyr Thr Val Lys Asp Cys Tyr Pro Val Gln Glu Thr Phe Thr Ile Asn 
65                  70                  75                  80  


Tyr Ser Val Ile Leu Ser Thr Arg Phe Phe Asp Ile Gln Leu Gly Ile 
                85                  90                  95      


Lys Asp Pro Ser Val Phe Thr Pro Pro Ser Thr Cys Gln Met Ala Gln 
            100                 105                 110         


Leu Glu Lys Met Ser Glu Asp Cys Ser Trp 
        115                 120         


<210>  4786
<211>  90
<212>  PRT
<213>  Homo Sapiens

<400>  4786

Met Pro Gly Arg Ala Pro Leu Arg Thr Val Pro Gly Ala Leu Gly Ala 
1               5                   10                  15      


Trp Leu Leu Gly Gly Leu Trp Ala Trp Thr Leu Cys Gly Leu Cys Ser 
            20                  25                  30          


Leu Gly Ala Val Gly Ala Pro Arg Pro Cys Gln Ala Pro Gln Gln Trp 
        35                  40                  45              


Glu Gly Arg Gln Val Met Tyr Gln Gln Ser Ser Gly Arg Asn Ser Arg 
    50                  55                  60                  


Ala Leu Leu Ser Tyr Asp Gly Leu Asn Gln Arg Val Arg Val Leu Asp 
65                  70                  75                  80  


Glu Arg Lys Ala Leu Ile Pro Cys Lys Arg 
                85                  90  


<210>  4787
<211>  224
<212>  PRT
<213>  Homo Sapiens

<400>  4787

Met Pro Gly Arg Ala Pro Leu Arg Thr Val Pro Gly Ala Leu Gly Ala 
1               5                   10                  15      


Trp Leu Leu Gly Gly Leu Trp Ala Trp Thr Leu Cys Gly Leu Cys Ser 
            20                  25                  30          


Leu Gly Ala Val Gly Ala Pro Arg Pro Cys Gln Ala Pro Gln Gln Trp 
        35                  40                  45              


Glu Gly Arg Gln Val Met Tyr Gln Gln Ser Ser Gly Arg Asn Ser Arg 
    50                  55                  60                  


Ala Leu Leu Ser Tyr Asp Gly Leu Asn Gln Arg Val Arg Val Leu Asp 
65                  70                  75                  80  


Glu Arg Lys Ala Leu Ile Pro Cys Lys Arg Leu Phe Glu Tyr Ile Leu 
                85                  90                  95      


Leu Tyr Lys Asp Gly Val Met Phe Gln Ile Asp Gln Ala Thr Lys Gln 
            100                 105                 110         


Cys Ser Lys Met Thr Leu Thr Gln Pro Trp Asp Pro Leu Asp Ile Pro 
        115                 120                 125             


Gln Asn Ser Thr Phe Glu Asp Gln Tyr Ser Ile Gly Gly Pro Gln Glu 
    130                 135                 140                 


Gln Ile Thr Val Gln Glu Trp Ser Asp Arg Lys Ser Ala Arg Ser Tyr 
145                 150                 155                 160 


Glu Thr Trp Ile Gly Ile Tyr Thr Val Lys Asp Cys Tyr Pro Val Gln 
                165                 170                 175     


Glu Thr Phe Thr Ile Asn Tyr Ser Val Ile Leu Ser Thr Arg Phe Phe 
            180                 185                 190         


Asp Ile Gln Leu Gly Ile Lys Asp Pro Ser Val Phe Thr Pro Pro Ser 
        195                 200                 205             


Thr Cys Gln Met Ala Gln Leu Glu Lys Met Ser Glu Asp Cys Ser Trp 
    210                 215                 220                 


<210>  4788
<211>  163
<212>  PRT
<213>  Homo Sapiens

<400>  4788

Met Val Arg Asp Trp Glu Gly Arg Cys Ala His Arg Gly Arg Pro Ala 
1               5                   10                  15      


Gly Gly Gly Leu Ser Asn Thr Gln Arg Gly Gly Gly Arg Leu Phe Glu 
            20                  25                  30          


Tyr Ile Leu Leu Tyr Lys Asp Gly Val Met Phe Gln Ile Asp Gln Ala 
        35                  40                  45              


Thr Lys Gln Cys Ser Lys Met Thr Leu Thr Gln Pro Trp Asp Pro Leu 
    50                  55                  60                  


Asp Ile Pro Gln Asn Ser Thr Phe Glu Asp Gln Tyr Ser Ile Gly Gly 
65                  70                  75                  80  


Pro Gln Glu Gln Ile Thr Val Gln Glu Trp Ser Asp Arg Lys Ser Ala 
                85                  90                  95      


Arg Ser Tyr Glu Thr Trp Ile Gly Ile Tyr Thr Val Lys Asp Cys Tyr 
            100                 105                 110         


Pro Val Gln Glu Thr Phe Thr Ile Asn Tyr Ser Val Ile Leu Ser Thr 
        115                 120                 125             


Arg Phe Phe Asp Ile Gln Leu Gly Ile Lys Asp Pro Ser Val Phe Thr 
    130                 135                 140                 


Pro Pro Ser Thr Cys Gln Met Ala Gln Leu Glu Lys Met Ser Glu Asp 
145                 150                 155                 160 


Cys Ser Trp 
            


<210>  4789
<211>  73
<212>  PRT
<213>  Homo Sapiens

<400>  4789

Met Ala Leu Gly Val Pro Ile Ser Val Tyr Leu Leu Phe Asn Ala Asp 
1               5                   10                  15      


Asn Ile Glu Gly Pro Ile Ala Leu Lys Phe Ser His Leu Cys Leu Glu 
            20                  25                  30          


Asp His Asn Ser Tyr Cys Ile Asn Gly Ala Cys Ala Phe His His Glu 
        35                  40                  45              


Leu Glu Lys Ala Ile Cys Arg Cys Leu Lys Leu Lys Ser Pro Tyr Asn 
    50                  55                  60                  


Val Cys Ser Gly Glu Arg Arg Pro Leu 
65                  70              


<210>  4790
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  4790

Met Ala Leu Gly Val Pro Ile Ser Val Tyr Leu Leu Phe Asn Ala Met 
1               5                   10                  15      


Thr Ala Leu Thr Glu Glu Ala Ala Val Thr Val Thr Pro Pro Ile Thr 
            20                  25                  30          


Ala Gln Gln Ala Asp Asn Ile Glu Gly Pro Ile Ala Leu Lys Phe Ser 
        35                  40                  45              


His Leu Cys Leu Glu Asp His Asn Ser Tyr Cys Ile Asn Gly Ala Cys 
    50                  55                  60                  


Ala Phe His His Glu Leu Glu Lys Ala Ile Cys Arg Cys Phe Thr Gly 
65                  70                  75                  80  


Tyr Thr Gly Glu Arg Cys Glu His Leu Thr Leu Thr Ser Tyr Ala Val 
                85                  90                  95      


Asp Ser Tyr Glu Lys Tyr Ile Ala Ile Gly Ile Gly Val Gly Leu Leu 
            100                 105                 110         


Leu Ser Gly Phe Leu Val Ile Phe Tyr Cys Tyr Ile Arg Lys Arg Tyr 
        115                 120                 125             


Glu Lys Asp Lys Ile 
    130             


<210>  4791
<211>  103
<212>  PRT
<213>  Homo Sapiens

<400>  4791

Met Ala Leu Gly Val Pro Ile Ser Val Tyr Leu Leu Phe Asn Ala Met 
1               5                   10                  15      


Thr Ala Leu Thr Glu Glu Ala Ala Val Thr Val Thr Pro Pro Ile Thr 
            20                  25                  30          


Ala Gln Gln Ala Asp Asn Ile Glu Gly Pro Ile Ala Leu Lys Phe Ser 
        35                  40                  45              


His Leu Cys Leu Glu Asp His Asn Ser Tyr Cys Ile Asn Gly Ala Cys 
    50                  55                  60                  


Ala Phe His His Glu Leu Glu Lys Ala Ile Cys Arg Cys Phe Thr Gly 
65                  70                  75                  80  


Tyr Thr Gly Glu Arg Cys Leu Lys Leu Lys Ser Pro Tyr Asn Val Cys 
                85                  90                  95      


Ser Gly Glu Arg Arg Pro Leu 
            100             


<210>  4792
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  4792

Met Ala Leu Gly Val Pro Ile Ser Val Tyr Leu Leu Phe Asn Ala Met 
1               5                   10                  15      


Thr Ala Leu Thr Glu Glu Ala Ala Val Thr Val Thr Pro Pro Ile Thr 
            20                  25                  30          


Ala Gln Gln Ala Asp Asn Ile Glu Gly Pro Ile Ala Leu Lys Phe Ser 
        35                  40                  45              


His Leu Cys Leu Glu Asp His Asn Ser Tyr Cys Ile Asn Gly Ala Cys 
    50                  55                  60                  


Ala Phe His His Glu Leu Glu Lys Ala Ile Cys Arg Cys Leu Lys Leu 
65                  70                  75                  80  


Lys Ser Pro Tyr Asn Val Cys Ser Gly Glu Arg Arg Pro Leu 
                85                  90                  


<210>  4793
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  4793

Met Ala Leu Gly Val Pro Ile Ser Val Tyr Leu Leu Phe Asn Ala Met 
1               5                   10                  15      


Thr Ala Leu Thr Glu Glu Ala Ala Val Thr Val Thr Pro Pro Ile Thr 
            20                  25                  30          


Ala Gln Gln Gly Asn Trp Thr Val Asn Lys Thr Glu Ala Asp Asn Ile 
        35                  40                  45              


Glu Gly Pro Ile Ala Leu Lys Phe Ser His Leu Cys Leu Glu Asp His 
    50                  55                  60                  


Asn Ser Tyr Cys Ile Asn Gly Ala Cys Ala Phe His His Glu Leu Glu 
65                  70                  75                  80  


Lys Ala Ile Cys Arg Cys Phe Thr Gly Tyr Thr Gly Glu Arg 
                85                  90                  


<210>  4794
<211>  154
<212>  PRT
<213>  Homo Sapiens

<400>  4794

Met Ala Leu Gly Val Pro Ile Ser Val Tyr Leu Leu Phe Asn Ala Met 
1               5                   10                  15      


Thr Ala Leu Thr Glu Glu Ala Ala Val Thr Val Thr Pro Pro Ile Thr 
            20                  25                  30          


Ala Gln Gln Gly Asn Trp Thr Val Asn Lys Thr Glu Ala Asp Asn Ile 
        35                  40                  45              


Glu Gly Pro Ile Ala Leu Lys Phe Ser His Leu Cys Leu Glu Asp His 
    50                  55                  60                  


Asn Ser Tyr Cys Ile Asn Gly Ala Cys Ala Phe His His Glu Leu Glu 
65                  70                  75                  80  


Lys Ala Ile Cys Arg Cys Phe Thr Gly Tyr Thr Gly Glu Arg Cys Glu 
                85                  90                  95      


His Leu Thr Leu Thr Ser Tyr Ala Val Asp Ser Tyr Glu Lys Tyr Ile 
            100                 105                 110         


Ala Ile Gly Ile Gly Val Gly Leu Leu Leu Ser Gly Phe Leu Val Ile 
        115                 120                 125             


Phe Tyr Cys Tyr Ile Arg Lys Arg Cys Leu Lys Leu Lys Ser Pro Tyr 
    130                 135                 140                 


Asn Val Cys Ser Gly Glu Arg Arg Pro Leu 
145                 150                 


<210>  4795
<211>  112
<212>  PRT
<213>  Homo Sapiens

<400>  4795

Met Ala Leu Gly Val Pro Ile Ser Val Tyr Leu Leu Phe Asn Ala Met 
1               5                   10                  15      


Thr Ala Leu Thr Glu Glu Ala Ala Val Thr Val Thr Pro Pro Ile Thr 
            20                  25                  30          


Ala Gln Gln Gly Asn Trp Thr Val Asn Lys Thr Glu Ala Asp Asn Ile 
        35                  40                  45              


Glu Gly Pro Ile Ala Leu Lys Phe Ser His Leu Cys Leu Glu Asp His 
    50                  55                  60                  


Asn Ser Tyr Cys Ile Asn Gly Ala Cys Ala Phe His His Glu Leu Glu 
65                  70                  75                  80  


Lys Ala Ile Cys Arg Cys Phe Thr Gly Tyr Thr Gly Glu Arg Cys Leu 
                85                  90                  95      


Lys Leu Lys Ser Pro Tyr Asn Val Cys Ser Gly Glu Arg Arg Pro Leu 
            100                 105                 110         


<210>  4796
<211>  103
<212>  PRT
<213>  Homo Sapiens

<400>  4796

Met Ala Leu Gly Val Pro Ile Ser Val Tyr Leu Leu Phe Asn Ala Met 
1               5                   10                  15      


Thr Ala Leu Thr Glu Glu Ala Ala Val Thr Val Thr Pro Pro Ile Thr 
            20                  25                  30          


Ala Gln Gln Gly Asn Trp Thr Val Asn Lys Thr Glu Ala Asp Asn Ile 
        35                  40                  45              


Glu Gly Pro Ile Ala Leu Lys Phe Ser His Leu Cys Leu Glu Asp His 
    50                  55                  60                  


Asn Ser Tyr Cys Ile Asn Gly Ala Cys Ala Phe His His Glu Leu Glu 
65                  70                  75                  80  


Lys Ala Ile Cys Arg Cys Leu Lys Leu Lys Ser Pro Tyr Asn Val Cys 
                85                  90                  95      


Ser Gly Glu Arg Arg Pro Leu 
            100             


<210>  4797
<211>  130
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4797

Xaa Thr Ala Leu Thr Glu Glu Ala Ala Val Thr Val Thr Pro Pro Ile 
1               5                   10                  15      


Thr Ala Gln Gln Ala Asp Asn Ile Glu Gly Pro Ile Ala Leu Lys Phe 
            20                  25                  30          


Ser His Leu Cys Leu Glu Asp His Asn Ser Tyr Cys Ile Asn Gly Ala 
        35                  40                  45              


Cys Ala Phe His His Glu Leu Glu Lys Ala Ile Cys Arg Cys Phe Thr 
    50                  55                  60                  


Gly Tyr Thr Gly Glu Arg Cys Glu His Leu Thr Leu Thr Ser Tyr Ala 
65                  70                  75                  80  


Val Asp Ser Tyr Glu Lys Tyr Ile Ala Ile Gly Ile Gly Val Gly Leu 
                85                  90                  95      


Leu Leu Ser Gly Phe Leu Val Ile Phe Tyr Cys Tyr Ile Arg Lys Arg 
            100                 105                 110         


Cys Leu Lys Leu Lys Ser Pro Tyr Asn Val Cys Ser Gly Glu Arg Arg 
        115                 120                 125             


Pro Leu 
    130 


<210>  4798
<211>  218
<212>  PRT
<213>  Homo Sapiens

<400>  4798

Ala Gln Val Thr Val Ser Thr Gly Pro Gly Ala Pro Trp Glu Glu Asp 
1               5                   10                  15      


Glu Ile Arg Arg Asp Arg Val Glu Pro Gln Ser Val Ser Leu Ser Trp 
            20                  25                  30          


Arg Glu Pro Ile Pro Ala Gly Ala Pro Gly Ala Asn Asp Thr Glu Tyr 
        35                  40                  45              


Glu Ile Arg Tyr Tyr Glu Lys Gly Gln Ser Glu Gln Thr Tyr Ser Met 
    50                  55                  60                  


Val Lys Thr Gly Ala Pro Thr Val Thr Val Thr Asn Leu Lys Pro Ala 
65                  70                  75                  80  


Thr Arg Tyr Val Phe Gln Ile Arg Ala Ala Ser Pro Gly Pro Ser Trp 
                85                  90                  95      


Glu Ala Gln Ser Phe Asn Pro Ser Ile Glu Val Gln Thr Leu Gly Glu 
            100                 105                 110         


Ala Ala Ser Gly Ser Arg Asp Gln Ser Pro Ala Ile Val Val Thr Val 
        115                 120                 125             


Val Thr Ile Ser Ala Leu Leu Val Leu Gly Ser Val Met Ser Val Leu 
    130                 135                 140                 


Ala Ile Trp Arg Arg Pro Cys Ser Tyr Gly Lys Gly Gly Gly Asp Ala 
145                 150                 155                 160 


His Asp Glu Glu Glu Leu Tyr Phe His Phe Lys Val Pro Thr Arg Arg 
                165                 170                 175     


Thr Phe Leu Asp Pro Gln Ser Cys Gly Asp Leu Leu Gln Ala Val His 
            180                 185                 190         


Leu Phe Ala Lys Glu Leu Asp Ala Lys Ser Val Thr Leu Glu Arg Ser 
        195                 200                 205             


Leu Gly Gly Gly Leu Glu Thr Ser Pro His 
    210                 215             


<210>  4799
<211>  392
<212>  PRT
<213>  Homo Sapiens

<400>  4799

Glu Gln Thr Tyr Ser Met Val Lys Thr Gly Ala Pro Thr Val Thr Val 
1               5                   10                  15      


Thr Asn Leu Lys Pro Ala Thr Arg Tyr Val Phe Gln Ile Arg Ala Ala 
            20                  25                  30          


Ser Pro Gly Pro Ser Trp Glu Ala Gln Ser Phe Asn Pro Ser Ile Glu 
        35                  40                  45              


Val Gln Thr Leu Gly Glu Ala Ala Ser Gly Ser Arg Asp Gln Ser Pro 
    50                  55                  60                  


Ala Ile Val Val Thr Val Val Thr Ile Ser Ala Leu Leu Val Leu Gly 
65                  70                  75                  80  


Ser Val Met Ser Val Leu Ala Ile Trp Arg Arg Pro Cys Ser Tyr Gly 
                85                  90                  95      


Lys Gly Gly Gly Asp Ala His Asp Glu Glu Glu Leu Tyr Phe His Phe 
            100                 105                 110         


Lys Val Pro Thr Arg Arg Thr Phe Leu Asp Pro Gln Ser Cys Gly Asp 
        115                 120                 125             


Leu Leu Gln Ala Val His Leu Phe Ala Lys Glu Leu Asp Ala Lys Ser 
    130                 135                 140                 


Val Thr Leu Glu Arg Ser Leu Gly Gly Gly Arg Phe Gly Glu Leu Cys 
145                 150                 155                 160 


Cys Gly Cys Leu Gln Leu Pro Gly Arg Gln Glu Leu Leu Val Ala Val 
                165                 170                 175     


His Met Leu Arg Asp Ser Ala Ser Asp Ser Gln Arg Leu Gly Phe Leu 
            180                 185                 190         


Ala Glu Ala Leu Thr Leu Gly Gln Phe Asp His Ser His Ile Val Arg 
        195                 200                 205             


Leu Glu Gly Val Val Thr Arg Gly Ser Thr Leu Met Ile Val Thr Glu 
    210                 215                 220                 


Tyr Met Ser His Gly Ala Leu Asp Gly Phe Leu Arg Arg His Glu Gly 
225                 230                 235                 240 


Gln Leu Val Ala Gly Gln Leu Met Gly Leu Leu Pro Gly Leu Ala Ser 
                245                 250                 255     


Ala Met Lys Tyr Leu Ser Glu Met Gly Tyr Val His Arg Gly Leu Ala 
            260                 265                 270         


Ala Arg His Val Leu Val Ser Ser Asp Leu Val Cys Lys Ile Ser Gly 
        275                 280                 285             


Phe Gly Arg Gly Pro Arg Asp Arg Ser Glu Ala Val Tyr Thr Thr Met 
    290                 295                 300                 


Ser Gly Arg Ser Pro Ala Leu Trp Ala Ala Pro Glu Thr Leu Gln Phe 
305                 310                 315                 320 


Gly His Phe Ser Ser Ala Ser Asp Val Trp Ser Phe Gly Ile Ile Met 
                325                 330                 335     


Trp Glu Val Met Ala Phe Gly Glu Arg Pro Tyr Trp Asp Met Ser Gly 
            340                 345                 350         


Gln Asp Val Ile Lys Ala Val Glu Asp Gly Phe Arg Leu Pro Pro Pro 
        355                 360                 365             


Arg Asn Cys Pro Asn Leu Leu His Arg Leu Met Leu Asp Cys Trp Gln 
    370                 375                 380                 


Lys Asp Pro Gly Leu Pro Pro His 
385                 390         


<210>  4800
<211>  295
<212>  PRT
<213>  Homo Sapiens

<400>  4800

Met Glu Thr Cys Ala Gly Pro His Pro Leu Arg Leu Phe Leu Cys Arg 
1               5                   10                  15      


Met Gln Leu Cys Leu Ala Leu Leu Leu Gly Pro Trp Arg Pro Gly Thr 
            20                  25                  30          


Ala Glu Glu Val Ile Leu Leu Asp Ser Lys Ala Ser Gln Ala Glu Leu 
        35                  40                  45              


Gly Trp Thr Ala Leu Pro Ser Asn Gly Trp Glu Glu Ile Ser Gly Val 
    50                  55                  60                  


Asp Glu His Asp Arg Pro Ile Arg Thr Tyr Gln Val Cys Asn Val Leu 
65                  70                  75                  80  


Glu Pro Asn Gln Asp Asn Trp Leu Gln Thr Gly Trp Ile Ser Arg Gly 
                85                  90                  95      


Arg Gly Gln Arg Ile Phe Val Glu Leu Gln Phe Thr Leu Arg Asp Cys 
            100                 105                 110         


Ser Ser Ile Pro Gly Ala Ala Gly Thr Cys Lys Glu Thr Phe Asn Val 
        115                 120                 125             


Tyr Tyr Leu Glu Thr Glu Ala Asp Leu Gly Arg Gly Arg Pro Arg Leu 
    130                 135                 140                 


Gly Gly Ser Arg Pro Arg Lys Ile Asp Thr Ile Ala Ala Asp Glu Ser 
145                 150                 155                 160 


Phe Thr Gln Gly Asp Leu Gly Glu Arg Lys Met Lys Leu Asn Thr Glu 
                165                 170                 175     


Val Arg Glu Ile Gly Pro Leu Ser Arg Arg Gly Phe His Leu Ala Phe 
            180                 185                 190         


Gln Asp Val Gly Ala Cys Val Ala Leu Val Ser Val Arg Val Tyr Tyr 
        195                 200                 205             


Lys Gln Cys Arg Ala Thr Val Arg Gly Leu Ala Thr Phe Pro Ala Thr 
    210                 215                 220                 


Ala Ala Glu Ser Ala Phe Ser Thr Leu Val Glu Val Ala Gly Thr Cys 
225                 230                 235                 240 


Val Ala His Ser Glu Gly Glu Pro Gly Ser Pro Pro Arg Met His Cys 
                245                 250                 255     


Gly Ala Asp Gly Glu Trp Leu Val Pro Val Gly Arg Cys Ser Cys Ser 
            260                 265                 270         


Ala Gly Phe Gln Glu Arg Gly Asp Phe Cys Glu Gly Ile Gln Leu Ala 
        275                 280                 285             


Gly Gly Arg Gly Val Gly Val 
    290                 295 


<210>  4801
<211>  1008
<212>  PRT
<213>  Homo Sapiens

<400>  4801

Met Glu Thr Cys Ala Gly Pro His Pro Leu Arg Leu Phe Leu Cys Arg 
1               5                   10                  15      


Met Gln Leu Cys Leu Ala Leu Leu Leu Gly Pro Trp Arg Pro Gly Thr 
            20                  25                  30          


Ala Glu Glu Val Ile Leu Leu Asp Ser Lys Ala Ser Gln Ala Glu Leu 
        35                  40                  45              


Gly Trp Thr Ala Leu Pro Ser Asn Gly Trp Glu Glu Ile Ser Gly Val 
    50                  55                  60                  


Asp Glu His Asp Arg Pro Ile Arg Thr Tyr Gln Val Cys Asn Val Leu 
65                  70                  75                  80  


Glu Pro Asn Gln Asp Asn Trp Leu Gln Thr Gly Trp Ile Ser Arg Gly 
                85                  90                  95      


Arg Gly Gln Arg Ile Phe Val Glu Leu Gln Phe Thr Leu Arg Asp Cys 
            100                 105                 110         


Ser Ser Ile Pro Gly Ala Ala Gly Thr Cys Lys Glu Thr Phe Asn Val 
        115                 120                 125             


Tyr Tyr Leu Glu Thr Glu Ala Asp Leu Gly Arg Gly Arg Pro Arg Leu 
    130                 135                 140                 


Gly Gly Ser Arg Pro Arg Lys Ile Asp Thr Ile Ala Ala Asp Glu Ser 
145                 150                 155                 160 


Phe Thr Gln Gly Asp Leu Gly Glu Arg Lys Met Lys Leu Asn Thr Glu 
                165                 170                 175     


Val Arg Glu Ile Gly Pro Leu Ser Arg Arg Gly Phe His Leu Ala Phe 
            180                 185                 190         


Gln Asp Val Gly Ala Cys Val Ala Leu Val Ser Val Arg Val Tyr Tyr 
        195                 200                 205             


Lys Gln Cys Arg Ala Thr Val Arg Gly Leu Ala Thr Phe Pro Ala Thr 
    210                 215                 220                 


Ala Ala Glu Ser Ala Phe Ser Thr Leu Val Glu Val Ala Gly Thr Cys 
225                 230                 235                 240 


Val Ala His Ser Glu Gly Glu Pro Gly Ser Pro Pro Arg Met His Cys 
                245                 250                 255     


Gly Ala Asp Gly Glu Trp Leu Val Pro Val Gly Arg Cys Ser Cys Ser 
            260                 265                 270         


Ala Gly Phe Gln Glu Arg Gly Asp Phe Cys Glu Ala Cys Pro Pro Gly 
        275                 280                 285             


Phe Tyr Lys Val Ser Pro Arg Arg Pro Leu Cys Ser Pro Cys Pro Glu 
    290                 295                 300                 


His Ser Arg Ala Leu Glu Asn Ala Ser Thr Phe Cys Val Cys Gln Asp 
305                 310                 315                 320 


Ser Tyr Ala Arg Ser Pro Thr Asp Pro Pro Ser Ala Ser Cys Thr Arg 
                325                 330                 335     


Pro Pro Ser Ala Pro Arg Asp Leu Gln Tyr Ser Leu Ser Arg Ser Pro 
            340                 345                 350         


Leu Val Leu Arg Leu Arg Trp Leu Pro Pro Ala Asp Ser Gly Gly Arg 
        355                 360                 365             


Ser Asp Val Thr Tyr Ser Leu Leu Cys Leu Arg Cys Gly Arg Glu Gly 
    370                 375                 380                 


Pro Ala Gly Ala Cys Glu Pro Cys Gly Pro Arg Val Ala Phe Leu Pro 
385                 390                 395                 400 


Arg Gln Ala Gly Leu Arg Glu Arg Ala Ala Thr Leu Leu His Leu Arg 
                405                 410                 415     


Pro Gly Ala Arg Tyr Thr Val Arg Val Ala Ala Leu Asn Gly Val Ser 
            420                 425                 430         


Gly Pro Ala Ala Ala Ala Gly Thr Thr Tyr Ala Gln Val Thr Val Ser 
        435                 440                 445             


Thr Gly Pro Gly Ala Pro Trp Glu Glu Asp Glu Ile Arg Arg Asp Arg 
    450                 455                 460                 


Val Glu Pro Gln Ser Val Ser Leu Ser Trp Arg Glu Pro Ile Pro Ala 
465                 470                 475                 480 


Gly Ala Pro Gly Ala Asn Asp Thr Glu Tyr Glu Ile Arg Tyr Tyr Glu 
                485                 490                 495     


Lys Gly Gln Ser Glu Gln Thr Tyr Ser Met Val Lys Thr Gly Ala Pro 
            500                 505                 510         


Thr Val Thr Val Thr Asn Leu Lys Pro Ala Thr Arg Tyr Val Phe Gln 
        515                 520                 525             


Ile Arg Ala Ala Ser Pro Gly Pro Ser Trp Glu Ala Gln Ser Phe Asn 
    530                 535                 540                 


Pro Ser Ile Glu Val Gln Thr Leu Gly Glu Ala Ala Ser Gly Ser Arg 
545                 550                 555                 560 


Asp Gln Ser Pro Ala Ile Val Val Thr Val Val Thr Ile Ser Ala Leu 
                565                 570                 575     


Leu Val Leu Gly Ser Val Met Ser Val Leu Ala Ile Trp Arg Arg Pro 
            580                 585                 590         


Cys Ser Tyr Gly Lys Gly Gly Gly Asp Ala His Asp Glu Glu Glu Leu 
        595                 600                 605             


Tyr Phe His Phe Lys Val Pro Thr Arg Arg Thr Phe Leu Asp Pro Gln 
    610                 615                 620                 


Ser Cys Gly Asp Leu Leu Gln Ala Val His Leu Phe Ala Lys Glu Leu 
625                 630                 635                 640 


Asp Ala Lys Ser Val Thr Leu Glu Arg Ser Leu Gly Gly Gly Arg Phe 
                645                 650                 655     


Gly Glu Leu Cys Cys Gly Cys Leu Gln Leu Pro Gly Arg Gln Glu Leu 
            660                 665                 670         


Leu Val Ala Val His Met Leu Arg Asp Ser Ala Ser Asp Ser Gln Arg 
        675                 680                 685             


Leu Gly Phe Leu Ala Glu Ala Leu Thr Leu Gly Gln Phe Asp His Ser 
    690                 695                 700                 


His Ile Val Arg Leu Glu Gly Val Val Thr Arg Gly Ser Thr Leu Met 
705                 710                 715                 720 


Ile Val Thr Glu Tyr Met Ser His Gly Ala Leu Asp Gly Phe Leu Arg 
                725                 730                 735     


Arg His Glu Gly Gln Leu Val Ala Gly Gln Leu Met Gly Leu Leu Pro 
            740                 745                 750         


Gly Leu Ala Ser Ala Met Lys Tyr Leu Ser Glu Met Gly Tyr Val His 
        755                 760                 765             


Arg Gly Leu Ala Ala Arg His Val Leu Val Ser Ser Asp Leu Val Cys 
    770                 775                 780                 


Lys Ile Ser Gly Phe Gly Arg Gly Pro Arg Asp Arg Ser Glu Ala Val 
785                 790                 795                 800 


Tyr Thr Thr Met Ser Gly Arg Ser Pro Ala Leu Trp Ala Ala Pro Glu 
                805                 810                 815     


Thr Leu Gln Phe Gly His Phe Ser Ser Ala Ser Asp Val Trp Ser Phe 
            820                 825                 830         


Gly Ile Ile Met Trp Glu Val Met Ala Phe Gly Glu Arg Pro Tyr Trp 
        835                 840                 845             


Asp Met Ser Gly Gln Asp Val Ile Lys Ala Val Glu Asp Gly Phe Arg 
    850                 855                 860                 


Leu Pro Pro Pro Arg Asn Cys Pro Asn Leu Leu His Arg Leu Met Leu 
865                 870                 875                 880 


Asp Cys Trp Gln Lys Asp Pro Gly Glu Arg Pro Arg Phe Ser Gln Ile 
                885                 890                 895     


His Ser Ile Leu Ser Lys Met Val Gln Asp Pro Glu Pro Pro Lys Cys 
            900                 905                 910         


Ala Leu Thr Thr Cys Pro Arg Pro Pro Thr Pro Leu Ala Asp Arg Ala 
        915                 920                 925             


Phe Ser Thr Phe Pro Ser Phe Gly Ser Val Gly Ala Trp Leu Glu Ala 
    930                 935                 940                 


Leu Asp Leu Cys Arg Tyr Lys Asp Ser Phe Ala Ala Ala Gly Tyr Gly 
945                 950                 955                 960 


Ser Leu Glu Ala Val Ala Glu Met Thr Ala Gln Asp Leu Val Ser Leu 
                965                 970                 975     


Gly Ile Ser Leu Ala Glu His Arg Glu Ala Leu Leu Ser Gly Ile Ser 
            980                 985                 990         


Ala Leu Gln Ala Arg Val Leu Gln  Leu Gln Gly Gln Gly  Val Gln Val 
        995                 1000                 1005             


<210>  4802
<211>  1014
<212>  PRT
<213>  Homo Sapiens

<400>  4802

Met Glu Thr Cys Ala Gly Pro His Pro Leu Arg Leu Phe Leu Cys Arg 
1               5                   10                  15      


Met Gln Leu Cys Leu Ala Leu Leu Leu Gly Pro Trp Arg Pro Gly Thr 
            20                  25                  30          


Ala Glu Glu Val Ile Leu Leu Asp Ser Lys Ala Ser Gln Ala Glu Leu 
        35                  40                  45              


Gly Trp Thr Ala Leu Pro Ser Asn Gly Trp Glu Glu Ile Ser Gly Val 
    50                  55                  60                  


Asp Glu His Asp Arg Pro Ile Arg Thr Tyr Gln Val Cys Asn Val Leu 
65                  70                  75                  80  


Glu Pro Asn Gln Asp Asn Trp Leu Gln Thr Gly Trp Ile Ser Arg Gly 
                85                  90                  95      


Arg Gly Gln Arg Ile Phe Val Glu Leu Gln Phe Thr Leu Arg Asp Cys 
            100                 105                 110         


Ser Ser Ile Pro Gly Ala Ala Gly Thr Cys Lys Glu Thr Phe Asn Val 
        115                 120                 125             


Tyr Tyr Leu Glu Thr Glu Ala Asp Leu Gly Arg Gly Arg Pro Arg Leu 
    130                 135                 140                 


Gly Gly Ser Arg Pro Arg Lys Ile Asp Thr Ile Ala Ala Asp Glu Ser 
145                 150                 155                 160 


Phe Thr Gln Gly Asp Leu Gly Glu Arg Lys Met Lys Leu Asn Thr Glu 
                165                 170                 175     


Val Arg Glu Ile Gly Pro Leu Ser Arg Arg Gly Phe His Leu Ala Phe 
            180                 185                 190         


Gln Asp Val Gly Ala Cys Val Ala Leu Val Ser Val Arg Val Tyr Tyr 
        195                 200                 205             


Lys Gln Cys Arg Ala Thr Val Arg Gly Leu Ala Thr Phe Pro Ala Thr 
    210                 215                 220                 


Ala Ala Glu Ser Ala Phe Ser Thr Leu Val Glu Val Ala Gly Thr Cys 
225                 230                 235                 240 


Val Ala His Ser Glu Gly Glu Pro Gly Ser Pro Pro Arg Met His Cys 
                245                 250                 255     


Gly Ala Asp Gly Glu Trp Leu Val Pro Val Gly Arg Cys Ser Cys Ser 
            260                 265                 270         


Ala Gly Phe Gln Glu Arg Gly Asp Phe Cys Glu Ala Cys Pro Pro Gly 
        275                 280                 285             


Phe Tyr Lys Val Ser Pro Arg Arg Pro Leu Cys Ser Pro Cys Pro Glu 
    290                 295                 300                 


His Ser Arg Ala Leu Glu Asn Ala Ser Thr Phe Cys Val Cys Gln Asp 
305                 310                 315                 320 


Ser Tyr Ala Arg Ser Pro Thr Asp Pro Pro Ser Ala Ser Cys Thr Arg 
                325                 330                 335     


Pro Pro Ser Ala Pro Arg Asp Leu Gln Tyr Ser Leu Ser Arg Ser Pro 
            340                 345                 350         


Leu Val Leu Arg Leu Arg Trp Leu Pro Pro Ala Asp Ser Gly Gly Arg 
        355                 360                 365             


Ser Asp Val Thr Tyr Ser Leu Leu Cys Leu Arg Cys Gly Arg Glu Gly 
    370                 375                 380                 


Pro Ala Gly Ala Cys Glu Pro Cys Gly Pro Arg Val Ala Phe Leu Pro 
385                 390                 395                 400 


Arg Gln Ala Gly Leu Arg Glu Arg Ala Ala Thr Leu Leu His Leu Arg 
                405                 410                 415     


Pro Gly Ala Arg Tyr Thr Val Arg Val Ala Ala Leu Asn Gly Val Ser 
            420                 425                 430         


Gly Pro Ala Ala Ala Ala Gly Thr Thr Tyr Ala Gln Val Thr Val Ser 
        435                 440                 445             


Thr Gly Pro Gly Ala Pro Trp Glu Glu Asp Glu Ile Arg Arg Asp Arg 
    450                 455                 460                 


Val Glu Pro Gln Ser Val Ser Leu Ser Trp Arg Glu Pro Ile Pro Ala 
465                 470                 475                 480 


Gly Ala Pro Gly Ala Asn Asp Thr Glu Tyr Glu Ile Arg Tyr Tyr Glu 
                485                 490                 495     


Lys Gly Gln Ser Glu Gln Thr Tyr Ser Met Val Lys Thr Gly Ala Pro 
            500                 505                 510         


Thr Val Thr Val Thr Asn Leu Lys Pro Ala Thr Arg Tyr Val Phe Gln 
        515                 520                 525             


Ile Arg Ala Ala Ser Pro Gly Pro Ser Trp Glu Ala Gln Ser Phe Asn 
    530                 535                 540                 


Pro Ser Ile Glu Val Gln Thr Leu Gly Glu Ala Ala Ser Gly Ser Arg 
545                 550                 555                 560 


Asp Gln Ser Pro Ala Ile Val Val Thr Val Val Thr Ile Ser Ala Leu 
                565                 570                 575     


Leu Val Leu Gly Ser Val Met Ser Val Leu Ala Ile Trp Arg Arg Pro 
            580                 585                 590         


Cys Ser Tyr Gly Lys Gly Gly Gly Asp Ala His Asp Glu Glu Glu Leu 
        595                 600                 605             


Tyr Phe His Phe Lys Val Pro Thr Arg Arg Thr Phe Leu Asp Pro Gln 
    610                 615                 620                 


Ser Cys Gly Asp Leu Leu Gln Ala Val His Leu Phe Ala Lys Glu Leu 
625                 630                 635                 640 


Asp Ala Lys Ser Val Thr Leu Glu Arg Ser Leu Gly Gly Gly Arg Phe 
                645                 650                 655     


Gly Glu Leu Cys Cys Gly Cys Leu Gln Leu Pro Gly Arg Gln Glu Leu 
            660                 665                 670         


Leu Val Ala Val His Met Leu Arg Asp Ser Ala Ser Asp Ser Gln Arg 
        675                 680                 685             


Leu Gly Phe Leu Ala Glu Ala Leu Thr Leu Gly Gln Phe Asp His Ser 
    690                 695                 700                 


His Ile Val Arg Leu Glu Gly Val Val Thr Arg Gly Ser Thr Leu Met 
705                 710                 715                 720 


Ile Val Thr Glu Tyr Met Ser His Gly Ala Leu Asp Gly Phe Leu Arg 
                725                 730                 735     


Arg His Glu Gly Gln Leu Val Ala Gly Gln Leu Met Gly Leu Leu Pro 
            740                 745                 750         


Gly Leu Ala Ser Ala Met Lys Tyr Leu Ser Glu Met Gly Tyr Val His 
        755                 760                 765             


Arg Gly Leu Ala Ala Arg His Val Leu Val Ser Ser Asp Leu Val Cys 
    770                 775                 780                 


Lys Ile Ser Gly Phe Gly Arg Gly Pro Arg Asp Arg Ser Glu Ala Val 
785                 790                 795                 800 


Tyr Thr Thr Met Ser Gly Arg Ser Pro Ala Leu Trp Ala Ala Pro Glu 
                805                 810                 815     


Thr Leu Gln Phe Gly His Phe Ser Ser Ala Ser Asp Val Trp Ser Phe 
            820                 825                 830         


Gly Ile Ile Met Trp Glu Val Met Ala Phe Gly Glu Arg Pro Tyr Trp 
        835                 840                 845             


Asp Met Ser Gly Gln Asp Val Ile Lys Ala Val Glu Asp Gly Phe Arg 
    850                 855                 860                 


Leu Pro Pro Pro Arg Asn Cys Pro Asn Leu Leu His Arg Leu Met Leu 
865                 870                 875                 880 


Asp Cys Trp Gln Lys Asp Pro Gly Glu Arg Pro Arg Phe Ser Gln Ile 
                885                 890                 895     


His Ser Ile Leu Ser Lys Met Val Gln Asp Pro Glu Pro Pro Lys Cys 
            900                 905                 910         


Ala Leu Thr Thr Cys Pro Arg Pro Pro Thr Pro Leu Ala Asp Arg Ala 
        915                 920                 925             


Phe Ser Thr Phe Pro Ser Phe Gly Ser Val Gly Ala Trp Leu Glu Ala 
    930                 935                 940                 


Leu Asp Leu Cys Arg Tyr Lys Asp Ser Phe Ala Ala Ala Gly Tyr Gly 
945                 950                 955                 960 


Ser Leu Glu Ala Val Ala Glu Met Thr Ala Gln Asp Leu Val Ser Leu 
                965                 970                 975     


Gly Ile Ser Leu Ala Glu His Arg Glu Ala Leu Leu Ser Gly Ile Ser 
            980                 985                 990         


Ala Leu Gln Ala Arg Val Leu Gln  Leu Gln Gly Gln Gly  Val Gln Val 
        995                 1000                 1005             


Ile Ile  Lys Thr Cys Leu 
    1010                 


<210>  4803
<211>  155
<212>  PRT
<213>  Homo Sapiens

<400>  4803

Met Val Lys Thr Gly Ala Pro Thr Val Thr Val Thr Asn Leu Lys Pro 
1               5                   10                  15      


Ala Thr Arg Tyr Val Phe Gln Ile Arg Ala Ala Ser Pro Gly Pro Ser 
            20                  25                  30          


Trp Glu Ala Gln Ser Phe Asn Pro Ser Ile Glu Val Gln Thr Leu Gly 
        35                  40                  45              


Glu Ala Ala Ser Gly Ser Arg Asp Gln Ser Pro Ala Ile Val Val Thr 
    50                  55                  60                  


Val Val Thr Ile Ser Ala Leu Leu Val Leu Gly Ser Val Met Ser Val 
65                  70                  75                  80  


Leu Ala Ile Trp Arg Arg Pro Cys Ser Tyr Gly Lys Gly Gly Gly Asp 
                85                  90                  95      


Ala His Asp Glu Glu Glu Leu Tyr Phe His Phe Lys Val Pro Thr Arg 
            100                 105                 110         


Arg Thr Phe Leu Asp Pro Gln Ser Cys Gly Asp Leu Leu Gln Ala Val 
        115                 120                 125             


His Leu Phe Ala Lys Glu Leu Asp Ala Lys Ser Val Thr Leu Glu Arg 
    130                 135                 140                 


Ser Leu Gly Gly Gly Leu Glu Thr Ser Pro His 
145                 150                 155 


<210>  4804
<211>  92
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4804

Xaa His Leu Arg Pro Gly Ala Arg Tyr Thr Val Arg Val Ala Ala Leu 
1               5                   10                  15      


Asn Gly Val Ser Gly Pro Ala Ala Ala Ala Gly Thr Thr Tyr Ala Gln 
            20                  25                  30          


Val Thr Val Ser Thr Gly Pro Gly Ala Pro Trp Glu Glu Asp Glu Ile 
        35                  40                  45              


Arg Arg Asp Arg Val Glu Pro Gln Ser Val Ser Leu Ser Trp Arg Glu 
    50                  55                  60                  


Pro Ile Pro Ala Gly Ala Pro Gly Ala Asn Asp Thr Glu Tyr Glu Ile 
65                  70                  75                  80  


Arg Tyr Tyr Glu Lys Asp Thr Cys Ala Asp Phe Cys 
                85                  90          


<210>  4805
<211>  217
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4805

Xaa Gln Ile Arg Ala Ala Ser Pro Gly Pro Ser Trp Glu Ala Gln Ser 
1               5                   10                  15      


Phe Asn Pro Ser Ile Glu Val Gln Thr Leu Gly Glu Ala Ala Ser Gly 
            20                  25                  30          


Ser Arg Asp Gln Ser Pro Ala Ile Val Val Thr Val Val Thr Ile Ser 
        35                  40                  45              


Ala Leu Leu Val Leu Gly Ser Val Met Ser Val Leu Ala Ile Trp Arg 
    50                  55                  60                  


Arg Pro Cys Ser Tyr Gly Lys Gly Gly Gly Asp Ala His Asp Glu Glu 
65                  70                  75                  80  


Glu Leu Tyr Phe His Phe Lys Val Pro Thr Arg Arg Thr Phe Leu Asp 
                85                  90                  95      


Pro Gln Ser Cys Gly Asp Leu Leu Gln Ala Val His Leu Phe Ala Lys 
            100                 105                 110         


Glu Leu Asp Ala Lys Ser Val Thr Leu Glu Arg Ser Leu Gly Gly Gly 
        115                 120                 125             


Leu Cys Ser Cys Leu Glu Ala Leu Pro Pro His Gln Ala His Pro Pro 
    130                 135                 140                 


Pro Arg Lys Ser Leu Ala Cys Leu Ile Ile Gly Lys Arg Met Ala Glu 
145                 150                 155                 160 


Gly Ser Val Thr Leu Ser Trp Ser Ser Arg Ala Val Trp Gly Ala Val 
                165                 170                 175     


Leu Trp Leu Leu Ala Ala Pro Arg Ser Pro Gly Ala Ala Arg Ser Arg 
            180                 185                 190         


Ala Tyr Ala Glu Gly Gln Arg Leu Arg Leu Thr Glu Ala Arg Leu Pro 
        195                 200                 205             


Gly Arg Gly Pro His Ala Gly Pro Val 
    210                 215         


<210>  4806
<211>  983
<212>  PRT
<213>  Homo Sapiens

<400>  4806

Met Asp Cys Gln Leu Ser Ile Leu Leu Leu Leu Ser Cys Ser Val Leu 
1               5                   10                  15      


Asp Ser Phe Gly Glu Leu Ile Pro Gln Pro Ser Asn Glu Val Asn Leu 
            20                  25                  30          


Leu Asp Ser Lys Thr Ile Gln Gly Glu Leu Gly Trp Ile Ser Tyr Pro 
        35                  40                  45              


Ser His Gly Trp Glu Glu Ile Ser Gly Val Asp Glu His Tyr Thr Pro 
    50                  55                  60                  


Ile Arg Thr Tyr Gln Val Cys Asn Val Met Asp His Ser Gln Asn Asn 
65                  70                  75                  80  


Trp Leu Arg Thr Asn Trp Val Pro Arg Asn Ser Ala Gln Lys Ile Tyr 
                85                  90                  95      


Val Glu Leu Lys Phe Thr Leu Arg Asp Cys Asn Ser Ile Pro Leu Val 
            100                 105                 110         


Leu Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Met Glu Ser Asp 
        115                 120                 125             


Asp Asp His Gly Val Lys Phe Arg Glu His Gln Phe Thr Lys Ile Asp 
    130                 135                 140                 


Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Met Asp Leu Gly Asp Arg 
145                 150                 155                 160 


Ile Leu Lys Leu Asn Thr Glu Ile Arg Glu Val Gly Pro Val Asn Lys 
                165                 170                 175     


Lys Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys Val Ala Leu 
            180                 185                 190         


Val Ser Val Arg Val Tyr Phe Lys Lys Cys Pro Phe Thr Val Lys Asn 
        195                 200                 205             


Leu Ala Met Phe Pro Asp Thr Val Pro Met Asp Ser Gln Ser Leu Val 
    210                 215                 220                 


Glu Val Arg Gly Ser Cys Val Asn Asn Ser Lys Glu Glu Asp Pro Pro 
225                 230                 235                 240 


Arg Met Tyr Cys Ser Thr Glu Gly Glu Trp Leu Val Pro Ile Gly Lys 
                245                 250                 255     


Cys Ser Cys Asn Ala Gly Tyr Glu Glu Arg Gly Phe Met Cys Gln Ala 
            260                 265                 270         


Cys Arg Pro Gly Phe Tyr Lys Ala Leu Asp Gly Asn Met Lys Cys Ala 
        275                 280                 285             


Lys Cys Pro Pro His Ser Ser Thr Gln Glu Asp Gly Ser Met Asn Cys 
    290                 295                 300                 


Arg Cys Glu Asn Asn Tyr Phe Arg Ala Asp Lys Asp Pro Pro Ser Met 
305                 310                 315                 320 


Ala Cys Thr Arg Pro Pro Ser Ser Pro Arg Asn Val Ile Ser Asn Ile 
                325                 330                 335     


Asn Glu Thr Ser Val Ile Leu Asp Trp Ser Trp Pro Leu Asp Thr Gly 
            340                 345                 350         


Gly Arg Lys Asp Val Thr Phe Asn Ile Ile Cys Lys Lys Cys Gly Trp 
        355                 360                 365             


Asn Ile Lys Gln Cys Glu Pro Cys Ser Pro Asn Val Arg Phe Leu Pro 
    370                 375                 380                 


Arg Gln Phe Gly Leu Thr Asn Thr Thr Val Thr Val Thr Asp Leu Leu 
385                 390                 395                 400 


Ala His Thr Asn Tyr Thr Phe Glu Ile Asp Ala Val Asn Gly Val Ser 
                405                 410                 415     


Glu Leu Ser Ser Pro Pro Arg Gln Phe Ala Ala Val Ser Ile Thr Thr 
            420                 425                 430         


Asn Gln Ala Ala Pro Ser Pro Val Leu Thr Ile Lys Lys Asp Arg Thr 
        435                 440                 445             


Ser Arg Asn Ser Ile Ser Leu Ser Trp Gln Glu Pro Glu His Pro Asn 
    450                 455                 460                 


Gly Ile Ile Leu Asp Tyr Glu Val Lys Tyr Tyr Glu Lys Gln Glu Gln 
465                 470                 475                 480 


Glu Thr Ser Tyr Thr Ile Leu Arg Ala Arg Gly Thr Asn Val Thr Ile 
                485                 490                 495     


Ser Ser Leu Lys Pro Asp Thr Ile Tyr Val Phe Gln Ile Arg Ala Arg 
            500                 505                 510         


Thr Ala Ala Gly Tyr Gly Thr Asn Ser Arg Lys Phe Glu Phe Glu Thr 
        515                 520                 525             


Ser Pro Asp Ser Phe Ser Ile Ser Gly Glu Ser Ser Gln Val Val Met 
    530                 535                 540                 


Ile Ala Ile Ser Ala Ala Val Ala Ile Ile Leu Leu Thr Val Val Ile 
545                 550                 555                 560 


Tyr Val Leu Ile Gly Arg Phe Cys Gly Tyr Lys Ser Lys His Gly Ala 
                565                 570                 575     


Asp Glu Lys Arg Leu His Phe Gly Asn Gly His Leu Lys Leu Pro Gly 
            580                 585                 590         


Leu Arg Thr Tyr Val Asp Pro His Thr Tyr Glu Asp Pro Thr Gln Ala 
        595                 600                 605             


Val His Glu Phe Ala Lys Glu Leu Asp Ala Thr Asn Ile Ser Ile Asp 
    610                 615                 620                 


Lys Val Val Gly Ala Gly Glu Phe Gly Glu Val Cys Ser Gly Arg Leu 
625                 630                 635                 640 


Lys Leu Pro Ser Lys Lys Glu Ile Ser Val Ala Ile Lys Thr Leu Lys 
                645                 650                 655     


Val Gly Tyr Thr Glu Lys Gln Arg Arg Asp Phe Leu Gly Glu Ala Ser 
            660                 665                 670         


Ile Met Gly Gln Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val 
        675                 680                 685             


Val Thr Lys Ser Lys Pro Val Met Ile Val Thr Glu Tyr Met Glu Asn 
    690                 695                 700                 


Gly Ser Leu Asp Ser Phe Leu Arg Lys His Asp Ala Gln Phe Thr Val 
705                 710                 715                 720 


Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ser Gly Met Lys Tyr 
                725                 730                 735     


Leu Ser Asp Met Gly Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile 
            740                 745                 750         


Leu Ile Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser 
        755                 760                 765             


Arg Val Leu Glu Asp Asp Pro Glu Ala Ala Tyr Thr Thr Arg Gly Gly 
    770                 775                 780                 


Lys Ile Pro Ile Arg Trp Thr Ser Pro Glu Ala Ile Ala Tyr Arg Lys 
785                 790                 795                 800 


Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Leu Trp Glu 
                805                 810                 815     


Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Glu Met Ser Asn Gln Asp 
            820                 825                 830         


Val Ile Lys Ala Val Asp Glu Gly Tyr Arg Leu Pro Pro Pro Met Asp 
        835                 840                 845             


Cys Pro Ala Ala Leu Tyr Gln Leu Met Leu Asp Cys Trp Gln Lys Asp 
    850                 855                 860                 


Arg Asn Asn Arg Pro Lys Phe Glu Gln Ile Val Ser Ile Leu Asp Lys 
865                 870                 875                 880 


Leu Ile Arg Asn Pro Gly Ser Leu Lys Ile Ile Thr Ser Ala Ala Ala 
                885                 890                 895     


Arg Pro Ser Asn Leu Leu Leu Asp Gln Ser Asn Val Asp Ile Thr Thr 
            900                 905                 910         


Phe Arg Thr Thr Gly Asp Trp Leu Asn Gly Val Trp Thr Ala His Cys 
        915                 920                 925             


Lys Glu Ile Phe Thr Gly Val Glu Tyr Ser Ser Cys Asp Thr Ile Ala 
    930                 935                 940                 


Lys Ile Ser Thr Asp Asp Met Lys Lys Val Gly Val Thr Val Val Gly 
945                 950                 955                 960 


Pro Gln Lys Lys Ile Ile Ser Ser Ile Lys Ala Leu Glu Thr Gln Ser 
                965                 970                 975     


Lys Asn Gly Pro Val Pro Val 
            980             


<210>  4807
<211>  918
<212>  PRT
<213>  Homo Sapiens

<400>  4807

Met Asp Cys Gln Leu Ser Ile Leu Leu Leu Leu Ser Cys Ser Val Leu 
1               5                   10                  15      


Asp Ser Phe Gly Glu Leu Ile Pro Gln Pro Ser Asn Glu Val Asn Leu 
            20                  25                  30          


Leu Asp Ser Lys Thr Ile Gln Gly Glu Leu Gly Trp Ile Ser Tyr Pro 
        35                  40                  45              


Ser His Gly Trp Glu Glu Ile Ser Gly Val Asp Glu His Tyr Thr Pro 
    50                  55                  60                  


Ile Arg Thr Tyr Gln Val Cys Asn Val Met Asp His Ser Gln Asn Asn 
65                  70                  75                  80  


Trp Leu Arg Thr Asn Trp Val Pro Arg Asn Ser Ala Gln Lys Ile Tyr 
                85                  90                  95      


Val Glu Leu Lys Phe Thr Leu Arg Asp Cys Asn Ser Ile Pro Leu Val 
            100                 105                 110         


Leu Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Met Glu Ser Asp 
        115                 120                 125             


Asp Asp His Gly Val Lys Phe Arg Glu His Gln Phe Thr Lys Ile Asp 
    130                 135                 140                 


Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Met Asp Leu Gly Asp Arg 
145                 150                 155                 160 


Ile Leu Lys Leu Asn Thr Glu Ile Arg Glu Val Gly Pro Val Asn Lys 
                165                 170                 175     


Lys Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys Val Ala Leu 
            180                 185                 190         


Val Ser Val Arg Val Tyr Phe Lys Lys Cys Pro Phe Thr Val Lys Asn 
        195                 200                 205             


Leu Ala Met Phe Pro Asp Thr Val Pro Met Asp Ser Gln Ser Leu Val 
    210                 215                 220                 


Glu Val Arg Gly Ser Cys Val Asn Asn Ser Lys Glu Glu Asp Pro Pro 
225                 230                 235                 240 


Arg Met Tyr Cys Ser Thr Glu Gly Glu Trp Leu Val Pro Ile Gly Lys 
                245                 250                 255     


Cys Ser Cys Asn Ala Gly Tyr Glu Glu Arg Gly Phe Met Cys Gln Ala 
            260                 265                 270         


Cys Arg Pro Gly Phe Tyr Lys Ala Leu Asp Gly Asn Met Lys Cys Ala 
        275                 280                 285             


Lys Cys Pro Pro His Ser Ser Thr Gln Glu Asp Gly Ser Met Asn Cys 
    290                 295                 300                 


Arg Cys Glu Asn Asn Tyr Phe Arg Ala Asp Lys Asp Pro Pro Ser Met 
305                 310                 315                 320 


Ala Cys Thr Arg Pro Pro Ser Ser Pro Arg Asn Val Ile Ser Asn Ile 
                325                 330                 335     


Asn Glu Thr Ser Val Ile Leu Asp Trp Ser Trp Pro Leu Asp Thr Gly 
            340                 345                 350         


Gly Arg Lys Asp Val Thr Phe Asn Ile Ile Cys Lys Lys Cys Gly Trp 
        355                 360                 365             


Asn Ile Lys Gln Cys Glu Pro Cys Ser Pro Asn Val Arg Phe Leu Pro 
    370                 375                 380                 


Arg Gln Phe Gly Leu Thr Asn Thr Thr Val Thr Val Thr Asp Leu Leu 
385                 390                 395                 400 


Ala His Thr Asn Tyr Thr Phe Glu Ile Asp Ala Val Asn Gly Val Ser 
                405                 410                 415     


Glu Leu Ser Ser Pro Pro Arg Gln Phe Ala Ala Val Ser Ile Thr Thr 
            420                 425                 430         


Asn Gln Ala Ala Pro Ser Pro Val Leu Thr Ile Lys Lys Asp Arg Thr 
        435                 440                 445             


Ser Arg Asn Ser Ile Ser Leu Ser Trp Gln Glu Pro Glu His Pro Asn 
    450                 455                 460                 


Gly Ile Ile Leu Asp Tyr Glu Val Lys Tyr Tyr Glu Lys Gln Glu Gln 
465                 470                 475                 480 


Glu Thr Ser Tyr Thr Ile Leu Arg Ala Arg Gly Thr Asn Val Thr Ile 
                485                 490                 495     


Ser Ser Leu Lys Pro Asp Thr Ile Tyr Val Phe Gln Ile Arg Ala Arg 
            500                 505                 510         


Thr Ala Ala Gly Tyr Gly Thr Asn Ser Arg Lys Phe Glu Phe Glu Thr 
        515                 520                 525             


Ser Pro Asp Ser Phe Ser Ile Ser Gly Glu Ser Ser Gln Val Val Met 
    530                 535                 540                 


Ile Ala Ile Ser Ala Ala Val Ala Ile Ile Leu Leu Thr Val Val Ile 
545                 550                 555                 560 


Tyr Val Leu Ile Gly Arg Phe Cys Gly Tyr Lys Ser Lys His Gly Ala 
                565                 570                 575     


Asp Glu Lys Arg Leu His Phe Gly Asn Gly His Leu Lys Leu Pro Gly 
            580                 585                 590         


Leu Arg Thr Tyr Val Asp Pro His Thr Tyr Glu Asp Pro Thr Gln Ala 
        595                 600                 605             


Val His Glu Phe Ala Lys Glu Leu Asp Ala Thr Asn Ile Ser Ile Asp 
    610                 615                 620                 


Lys Val Val Gly Ala Gly Glu Phe Gly Glu Val Cys Ser Gly Arg Leu 
625                 630                 635                 640 


Lys Leu Pro Ser Lys Lys Glu Ile Ser Val Ala Ile Lys Thr Leu Lys 
                645                 650                 655     


Val Gly Tyr Thr Glu Lys Gln Arg Arg Asp Phe Leu Gly Glu Ala Ser 
            660                 665                 670         


Ile Met Gly Gln Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val 
        675                 680                 685             


Val Thr Lys Ser Lys Pro Val Met Ile Val Thr Glu Tyr Met Glu Asn 
    690                 695                 700                 


Gly Ser Leu Asp Ser Phe Leu Arg Lys His Asp Ala Gln Phe Thr Val 
705                 710                 715                 720 


Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ser Gly Met Lys Tyr 
                725                 730                 735     


Leu Ser Asp Met Gly Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile 
            740                 745                 750         


Leu Ile Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser 
        755                 760                 765             


Arg Val Leu Glu Asp Asp Pro Glu Ala Ala Tyr Thr Thr Arg Gly Gly 
    770                 775                 780                 


Lys Ile Pro Ile Arg Trp Thr Ser Pro Glu Ala Ile Ala Tyr Arg Lys 
785                 790                 795                 800 


Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Leu Trp Glu 
                805                 810                 815     


Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Glu Met Ser Asn Gln Asp 
            820                 825                 830         


Val Ile Lys Ala Val Asp Glu Gly Tyr Arg Leu Pro Pro Pro Met Asp 
        835                 840                 845             


Cys Pro Ala Ala Leu Tyr Gln Leu Met Leu Asp Cys Trp Gln Lys Asp 
    850                 855                 860                 


Arg Asn Asn Arg Pro Lys Phe Glu Gln Ile Val Ser Ile Leu Asp Lys 
865                 870                 875                 880 


Leu Ile Arg Asn Pro Gly Ser Leu Lys Ile Ile Thr Ser Ala Ala Ala 
                885                 890                 895     


Arg Pro Ser Asn Leu Leu Leu Asp Gln Ser Asn Val Asp Ile Thr Thr 
            900                 905                 910         


Phe Arg Thr Thr Val Thr 
        915             


<210>  4808
<211>  539
<212>  PRT
<213>  Homo Sapiens

<400>  4808

Met Asp Cys Gln Leu Ser Ile Leu Leu Leu Leu Ser Cys Ser Val Leu 
1               5                   10                  15      


Asp Ser Phe Gly Glu Leu Ile Pro Gln Pro Ser Asn Glu Val Asn Leu 
            20                  25                  30          


Leu Asp Ser Lys Thr Ile Gln Gly Glu Leu Gly Trp Ile Ser Tyr Pro 
        35                  40                  45              


Ser His Gly Trp Glu Glu Ile Ser Gly Val Asp Glu His Tyr Thr Pro 
    50                  55                  60                  


Ile Arg Thr Tyr Gln Val Cys Asn Val Met Asp His Ser Gln Asn Asn 
65                  70                  75                  80  


Trp Leu Arg Thr Asn Trp Val Pro Arg Asn Ser Ala Gln Lys Ile Tyr 
                85                  90                  95      


Val Glu Leu Lys Phe Thr Leu Arg Asp Cys Asn Ser Ile Pro Leu Val 
            100                 105                 110         


Leu Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Met Glu Ser Asp 
        115                 120                 125             


Asp Asp His Gly Val Lys Phe Arg Glu His Gln Phe Thr Lys Ile Asp 
    130                 135                 140                 


Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Met Asp Leu Gly Asp Arg 
145                 150                 155                 160 


Ile Leu Lys Leu Asn Thr Glu Ile Arg Glu Val Gly Pro Val Asn Lys 
                165                 170                 175     


Lys Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys Val Ala Leu 
            180                 185                 190         


Val Ser Val Arg Val Tyr Phe Lys Lys Cys Pro Phe Thr Val Lys Asn 
        195                 200                 205             


Leu Ala Met Phe Pro Asp Thr Val Pro Met Asp Ser Gln Ser Leu Val 
    210                 215                 220                 


Glu Val Arg Gly Ser Cys Val Asn Asn Ser Lys Glu Glu Asp Pro Pro 
225                 230                 235                 240 


Arg Met Tyr Cys Ser Thr Glu Gly Glu Trp Leu Val Pro Ile Gly Lys 
                245                 250                 255     


Cys Ser Cys Asn Ala Gly Tyr Glu Glu Arg Gly Phe Met Cys Gln Ala 
            260                 265                 270         


Cys Arg Pro Gly Phe Tyr Lys Ala Leu Asp Gly Asn Met Lys Cys Ala 
        275                 280                 285             


Lys Cys Pro Pro His Ser Ser Thr Gln Glu Asp Gly Ser Met Asn Cys 
    290                 295                 300                 


Arg Cys Glu Asn Asn Tyr Phe Arg Ala Asp Lys Asp Pro Pro Ser Met 
305                 310                 315                 320 


Ala Cys Thr Arg Pro Pro Ser Ser Pro Arg Asn Val Ile Ser Asn Ile 
                325                 330                 335     


Asn Glu Thr Ser Val Ile Leu Asp Trp Ser Trp Pro Leu Asp Thr Gly 
            340                 345                 350         


Gly Arg Lys Asp Val Thr Phe Asn Ile Ile Cys Lys Lys Cys Gly Trp 
        355                 360                 365             


Asn Ile Lys Gln Cys Glu Pro Cys Ser Pro Asn Val Arg Phe Leu Pro 
    370                 375                 380                 


Arg Gln Phe Gly Leu Thr Asn Thr Thr Val Thr Val Thr Asp Leu Leu 
385                 390                 395                 400 


Ala His Thr Asn Tyr Thr Phe Glu Ile Asp Ala Val Asn Gly Val Ser 
                405                 410                 415     


Glu Leu Ser Ser Pro Pro Arg Gln Phe Ala Ala Val Ser Ile Thr Thr 
            420                 425                 430         


Asn Gln Ala Ala Pro Ser Pro Val Leu Thr Ile Lys Lys Asp Arg Thr 
        435                 440                 445             


Ser Arg Asn Ser Ile Ser Leu Ser Trp Gln Glu Pro Glu His Pro Asn 
    450                 455                 460                 


Gly Ile Ile Leu Asp Tyr Glu Val Lys Tyr Tyr Glu Lys Gln Glu Gln 
465                 470                 475                 480 


Glu Thr Ser Tyr Thr Ile Leu Arg Ala Arg Gly Thr Asn Val Thr Ile 
                485                 490                 495     


Ser Ser Leu Lys Pro Asp Thr Ile Tyr Val Phe Gln Ile Arg Ala Arg 
            500                 505                 510         


Thr Ala Ala Gly Tyr Gly Thr Asn Ser Arg Lys Phe Glu Phe Glu Thr 
        515                 520                 525             


Ser Pro Asp Cys Met Tyr Tyr Phe Asn Ala Val 
    530                 535                 


<210>  4809
<211>  37
<212>  PRT
<213>  Homo Sapiens

<400>  4809

Ala Tyr Arg Lys Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile 
1               5                   10                  15      


Val Met Trp Glu Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met 
            20                  25                  30          


Ser Asn Gln Asp Thr 
        35          


<210>  4810
<211>  177
<212>  PRT
<213>  Homo Sapiens

<400>  4810

Met Ala Gly Ile Phe Tyr Phe Ala Leu Phe Ser Cys Leu Phe Gly Ile 
1               5                   10                  15      


Cys Asp Ala Val Thr Gly Ser Arg Val Tyr Pro Ala Asn Glu Gly Pro 
            20                  25                  30          


Pro Ser Ala Pro Leu Asn Leu Ile Ser Asn Val Asn Glu Thr Ser Val 
        35                  40                  45              


Asn Leu Glu Trp Ser Ser Pro Gln Asn Thr Gly Gly Arg Gln Asp Ile 
    50                  55                  60                  


Ser Tyr Asn Val Val Cys Lys Lys Cys Gly Ala Gly Asp Pro Ser Lys 
65                  70                  75                  80  


Cys Arg Pro Cys Gly Ser Gly Val His Tyr Thr Pro Gln Gln Asn Gly 
                85                  90                  95      


Leu Lys Thr Thr Lys Val Ser Ile Thr Asp Leu Leu Ala His Thr Asn 
            100                 105                 110         


Tyr Thr Phe Glu Ile Trp Ala Val Asn Gly Val Ser Lys Tyr Asn Pro 
        115                 120                 125             


Asn Pro Asp Gln Ser Val Ser Val Thr Val Thr Thr Asn Gln Ala Ala 
    130                 135                 140                 


Pro Ser Ser Ile Ala Leu Val Gln Ala Lys Glu Val Thr Arg Tyr Ser 
145                 150                 155                 160 


Val Ala Leu Ala Trp Leu Glu Pro Asp Arg Pro Asn Gly Val Ile Leu 
                165                 170                 175     


Glu 
    


<210>  4811
<211>  38
<212>  PRT
<213>  Homo Sapiens

<400>  4811

Met Ala Gly Ile Phe Tyr Phe Ala Leu Phe Ser Cys Leu Phe Gly Ile 
1               5                   10                  15      


Cys Asp Ala Val Thr Gly Ser Arg Val Tyr Pro Ala Asn Glu Val Gly 
            20                  25                  30          


Gly Ser Glu Tyr His Gly 
        35              


<210>  4812
<211>  91
<212>  PRT
<213>  Homo Sapiens

<400>  4812

Met Ala Gly Ile Phe Tyr Phe Ala Leu Phe Ser Cys Leu Phe Gly Ile 
1               5                   10                  15      


Cys Asp Ala Val Thr Gly Ser Arg Val Tyr Pro Ala Asn Glu Val Thr 
            20                  25                  30          


Leu Leu Asp Ser Arg Ser Val Gln Gly Glu Leu Gly Trp Ile Ala Ser 
        35                  40                  45              


Pro Leu Glu Gly Gly Trp Glu Glu Val Ser Ile Met Asp Glu Lys Asn 
    50                  55                  60                  


Thr Pro Ile Arg Thr Tyr Gln Val Cys Asn Val Met Glu Pro Ser Gln 
65                  70                  75                  80  


Asn Asn Trp Leu Arg Thr Asp Trp Ile Thr Arg 
                85                  90      


<210>  4813
<211>  149
<212>  PRT
<213>  Homo Sapiens

<400>  4813

Met Ala Gly Ile Phe Tyr Phe Ala Leu Phe Ser Cys Leu Phe Gly Ile 
1               5                   10                  15      


Cys Asp Ala Val Thr Gly Ser Arg Val Tyr Pro Ala Asn Glu Val Thr 
            20                  25                  30          


Leu Leu Asp Ser Arg Ser Val Gln Gly Glu Leu Gly Trp Ile Ala Ser 
        35                  40                  45              


Pro Leu Glu Gly Gly Trp Glu Glu Val Ser Ile Met Asp Glu Lys Asn 
    50                  55                  60                  


Thr Pro Ile Arg Thr Tyr Gln Val Cys Asn Val Met Glu Pro Ser Gln 
65                  70                  75                  80  


Asn Asn Trp Leu Arg Thr Asp Trp Ile Thr Arg Glu Gly Ala Gln Arg 
                85                  90                  95      


Val Tyr Ile Glu Ile Lys Phe Thr Leu Arg Asp Cys Asn Ser Leu Pro 
            100                 105                 110         


Gly Val Met Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Tyr Glu 
        115                 120                 125             


Ser Asp Asn Asp Lys Glu Arg Phe Ile Arg Glu Asn Gln Phe Val Lys 
    130                 135                 140                 


Ile Asp Thr Ile Ala 
145                 


<210>  4814
<211>  986
<212>  PRT
<213>  Homo Sapiens

<400>  4814

Met Ala Gly Ile Phe Tyr Phe Ala Leu Phe Ser Cys Leu Phe Gly Ile 
1               5                   10                  15      


Cys Asp Ala Val Thr Gly Ser Arg Val Tyr Pro Ala Asn Glu Val Thr 
            20                  25                  30          


Leu Leu Asp Ser Arg Ser Val Gln Gly Glu Leu Gly Trp Ile Ala Ser 
        35                  40                  45              


Pro Leu Glu Gly Gly Trp Glu Glu Val Ser Ile Met Asp Glu Lys Asn 
    50                  55                  60                  


Thr Pro Ile Arg Thr Tyr Gln Val Cys Asn Val Met Glu Pro Ser Gln 
65                  70                  75                  80  


Asn Asn Trp Leu Arg Thr Asp Trp Ile Thr Arg Glu Gly Ala Gln Arg 
                85                  90                  95      


Val Tyr Ile Glu Ile Lys Phe Thr Leu Arg Asp Cys Asn Ser Leu Pro 
            100                 105                 110         


Gly Val Met Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Tyr Glu 
        115                 120                 125             


Ser Asp Asn Asp Lys Glu Arg Phe Ile Arg Glu Asn Gln Phe Val Lys 
    130                 135                 140                 


Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Val Asp Ile Gly 
145                 150                 155                 160 


Asp Arg Ile Met Lys Leu Asn Thr Glu Ile Arg Asp Val Gly Pro Leu 
                165                 170                 175     


Ser Lys Lys Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys Ile 
            180                 185                 190         


Ala Leu Val Ser Val Arg Val Phe Tyr Lys Lys Cys Pro Leu Thr Val 
        195                 200                 205             


Arg Asn Leu Ala Gln Phe Pro Asp Thr Ile Thr Gly Ala Asp Thr Ser 
    210                 215                 220                 


Ser Leu Val Glu Val Arg Gly Ser Cys Val Asn Asn Ser Glu Glu Lys 
225                 230                 235                 240 


Asp Val Pro Lys Met Tyr Cys Gly Ala Asp Gly Glu Trp Leu Val Pro 
                245                 250                 255     


Ile Gly Asn Cys Leu Cys Asn Ala Gly His Glu Glu Arg Ser Gly Glu 
            260                 265                 270         


Cys Gln Ala Cys Lys Ile Gly Tyr Tyr Lys Ala Leu Ser Thr Asp Ala 
        275                 280                 285             


Thr Cys Ala Lys Cys Pro Pro His Ser Tyr Ser Val Trp Glu Gly Ala 
    290                 295                 300                 


Thr Ser Cys Thr Cys Asp Arg Gly Phe Phe Arg Ala Asp Asn Asp Ala 
305                 310                 315                 320 


Ala Ser Met Pro Cys Thr Arg Pro Pro Ser Ala Pro Leu Asn Leu Ile 
                325                 330                 335     


Ser Asn Val Asn Glu Thr Ser Val Asn Leu Glu Trp Ser Ser Pro Gln 
            340                 345                 350         


Asn Thr Gly Gly Arg Gln Asp Ile Ser Tyr Asn Val Val Cys Lys Lys 
        355                 360                 365             


Cys Gly Ala Gly Asp Pro Ser Lys Cys Arg Pro Cys Gly Ser Gly Val 
    370                 375                 380                 


His Tyr Thr Pro Gln Gln Asn Gly Leu Lys Thr Thr Lys Val Ser Ile 
385                 390                 395                 400 


Thr Asp Leu Leu Ala His Thr Asn Tyr Thr Phe Glu Ile Trp Ala Val 
                405                 410                 415     


Asn Gly Val Ser Lys Tyr Asn Pro Asn Pro Asp Gln Ser Val Ser Val 
            420                 425                 430         


Thr Val Thr Thr Asn Gln Ala Ala Pro Ser Ser Ile Ala Leu Val Gln 
        435                 440                 445             


Ala Lys Glu Val Thr Arg Tyr Ser Val Ala Leu Ala Trp Leu Glu Pro 
    450                 455                 460                 


Asp Arg Pro Asn Gly Val Ile Leu Glu Tyr Glu Val Lys Tyr Tyr Glu 
465                 470                 475                 480 


Lys Asp Gln Asn Glu Arg Ser Tyr Arg Ile Val Arg Thr Ala Ala Arg 
                485                 490                 495     


Asn Thr Asp Ile Lys Gly Leu Asn Pro Leu Thr Ser Tyr Val Phe His 
            500                 505                 510         


Val Arg Ala Arg Thr Ala Ala Gly Tyr Gly Asp Phe Ser Glu Pro Leu 
        515                 520                 525             


Glu Val Thr Thr Asn Thr Val Pro Ser Arg Ile Ile Gly Asp Gly Ala 
    530                 535                 540                 


Asn Ser Thr Val Leu Leu Val Ser Val Ser Gly Ser Val Val Leu Val 
545                 550                 555                 560 


Val Ile Leu Ile Ala Ala Phe Val Ile Ser Arg Arg Arg Ser Lys Tyr 
                565                 570                 575     


Ser Lys Ala Lys Gln Glu Ala Asp Glu Glu Lys His Leu Asn Gln Gly 
            580                 585                 590         


Val Arg Thr Tyr Val Asp Pro Phe Thr Tyr Glu Asp Pro Asn Gln Ala 
        595                 600                 605             


Val Arg Glu Phe Ala Lys Glu Ile Asp Ala Ser Cys Ile Lys Ile Glu 
    610                 615                 620                 


Lys Val Ile Gly Val Gly Glu Phe Gly Glu Val Cys Ser Gly Arg Leu 
625                 630                 635                 640 


Lys Val Pro Gly Lys Arg Glu Ile Cys Val Ala Ile Lys Thr Leu Lys 
                645                 650                 655     


Ala Gly Tyr Thr Asp Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser 
            660                 665                 670         


Ile Met Gly Gln Phe Asp His Pro Asn Ile Ile His Leu Glu Gly Val 
        675                 680                 685             


Val Thr Lys Cys Lys Pro Val Met Ile Ile Thr Glu Tyr Met Glu Asn 
    690                 695                 700                 


Gly Ser Leu Asp Ala Phe Leu Arg Lys Asn Asp Gly Arg Phe Thr Val 
705                 710                 715                 720 


Ile Gln Leu Val Gly Met Leu Arg Gly Ile Gly Ser Gly Met Lys Tyr 
                725                 730                 735     


Leu Ser Asp Met Ser Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile 
            740                 745                 750         


Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Met Ser 
        755                 760                 765             


Arg Val Leu Glu Asp Asp Pro Glu Ala Ala Tyr Thr Thr Arg Gly Gly 
    770                 775                 780                 


Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala Tyr Arg Lys 
785                 790                 795                 800 


Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu 
                805                 810                 815     


Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp 
            820                 825                 830         


Val Ile Lys Ala Ile Glu Glu Gly Tyr Arg Leu Pro Pro Pro Met Asp 
        835                 840                 845             


Cys Pro Ile Ala Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Glu 
    850                 855                 860                 


Arg Ser Asp Arg Pro Lys Phe Gly Gln Ile Val Asn Met Leu Asp Lys 
865                 870                 875                 880 


Leu Ile Arg Asn Pro Asn Ser Leu Lys Arg Thr Gly Thr Glu Ser Ser 
                885                 890                 895     


Arg Pro Asn Thr Ala Leu Leu Asp Pro Ser Ser Pro Glu Phe Ser Ala 
            900                 905                 910         


Val Val Ser Val Gly Asp Trp Leu Gln Ala Ile Lys Met Asp Arg Tyr 
        915                 920                 925             


Lys Asp Asn Phe Thr Ala Ala Gly Tyr Thr Thr Leu Glu Ala Val Val 
    930                 935                 940                 


His Val Asn Gln Glu Asp Leu Ala Arg Ile Gly Ile Thr Ala Ile Thr 
945                 950                 955                 960 


His Gln Asn Lys Ile Leu Ser Ser Val Gln Ala Met Arg Thr Gln Met 
                965                 970                 975     


Gln Gln Met His Gly Arg Met Val Pro Val 
            980                 985     


<210>  4815
<211>  986
<212>  PRT
<213>  Homo Sapiens

<400>  4815

Met Ala Gly Ile Phe Tyr Phe Ala Leu Phe Ser Cys Leu Phe Gly Ile 
1               5                   10                  15      


Cys Asp Ala Val Thr Gly Ser Arg Val Tyr Pro Ala Asn Glu Val Thr 
            20                  25                  30          


Leu Leu Asp Ser Arg Ser Val Gln Gly Glu Leu Gly Trp Ile Ala Ser 
        35                  40                  45              


Pro Leu Glu Gly Gly Trp Glu Glu Val Ser Ile Met Asp Glu Lys Asn 
    50                  55                  60                  


Thr Pro Ile Arg Thr Tyr Gln Val Cys Asn Val Met Glu Pro Ser Gln 
65                  70                  75                  80  


Asn Asn Trp Leu Arg Thr Asp Trp Ile Thr Arg Glu Gly Ala Gln Arg 
                85                  90                  95      


Val Tyr Ile Glu Ile Lys Phe Thr Leu Arg Asp Cys Asn Ser Leu Pro 
            100                 105                 110         


Gly Val Met Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Tyr Glu 
        115                 120                 125             


Ser Asp Asn Asp Lys Glu Arg Phe Ile Arg Glu Asn Gln Phe Val Lys 
    130                 135                 140                 


Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Val Asp Ile Gly 
145                 150                 155                 160 


Asp Arg Ile Met Lys Leu Asn Thr Glu Ile Arg Asp Val Gly Pro Leu 
                165                 170                 175     


Ser Lys Lys Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys Ile 
            180                 185                 190         


Ala Leu Val Ser Val Arg Val Phe Tyr Lys Lys Cys Pro Leu Thr Val 
        195                 200                 205             


Arg Asn Leu Ala Gln Phe Pro Asp Thr Ile Thr Gly Ala Asp Thr Ser 
    210                 215                 220                 


Ser Leu Val Glu Val Arg Gly Ser Cys Val Asn Asn Ser Glu Glu Lys 
225                 230                 235                 240 


Asp Val Pro Lys Met Tyr Cys Gly Ala Asp Gly Glu Trp Leu Val Pro 
                245                 250                 255     


Ile Gly Asn Cys Leu Cys Asn Ala Gly His Glu Glu Arg Ser Gly Glu 
            260                 265                 270         


Cys Gln Ala Cys Lys Ile Gly Tyr Tyr Lys Ala Leu Ser Thr Asp Ala 
        275                 280                 285             


Thr Cys Ala Lys Cys Pro Pro His Ser Tyr Ser Val Trp Glu Gly Ala 
    290                 295                 300                 


Thr Ser Cys Thr Cys Asp Arg Gly Phe Phe Arg Ala Asp Asn Asp Ala 
305                 310                 315                 320 


Ala Ser Met Pro Cys Thr Arg Pro Pro Ser Ala Pro Leu Asn Leu Ile 
                325                 330                 335     


Ser Asn Val Asn Glu Thr Ser Val Asn Leu Glu Trp Ser Ser Pro Gln 
            340                 345                 350         


Asn Thr Gly Gly Arg Gln Asp Ile Ser Tyr Asn Val Val Cys Lys Lys 
        355                 360                 365             


Cys Gly Ala Gly Asp Pro Ser Lys Cys Arg Pro Cys Gly Ser Gly Val 
    370                 375                 380                 


His Tyr Thr Pro Gln Gln Asn Gly Leu Lys Thr Thr Lys Val Ser Ile 
385                 390                 395                 400 


Thr Asp Leu Leu Ala His Thr Asn Tyr Thr Phe Glu Ile Trp Ala Val 
                405                 410                 415     


Asn Gly Val Ser Lys Tyr Asn Pro Asn Pro Asp Gln Ser Val Ser Val 
            420                 425                 430         


Thr Val Thr Thr Asn Gln Ala Ala Pro Ser Ser Ile Ala Leu Val Gln 
        435                 440                 445             


Ala Lys Glu Val Thr Arg Tyr Ser Val Ala Leu Ala Trp Leu Glu Pro 
    450                 455                 460                 


Asp Arg Pro Asn Gly Val Ile Leu Glu Tyr Glu Val Lys Tyr Tyr Glu 
465                 470                 475                 480 


Lys Asp Gln Asn Glu Arg Ser Tyr Arg Ile Val Arg Thr Ala Ala Arg 
                485                 490                 495     


Asn Thr Asp Ile Lys Gly Leu Asn Pro Leu Thr Ser Tyr Val Phe His 
            500                 505                 510         


Val Arg Ala Arg Thr Ala Ala Gly Tyr Gly Asp Phe Ser Glu Pro Leu 
        515                 520                 525             


Glu Val Thr Thr Asn Thr Val Pro Ser Arg Ile Ile Gly Asp Gly Ala 
    530                 535                 540                 


Asn Ser Thr Val Leu Leu Val Ser Val Ser Gly Ser Val Val Leu Val 
545                 550                 555                 560 


Val Ile Leu Ile Ala Ala Phe Val Ile Ser Arg Arg Arg Ser Lys Tyr 
                565                 570                 575     


Ser Lys Ala Lys Gln Glu Ala Asp Glu Glu Lys His Leu Asn Gln Gly 
            580                 585                 590         


Val Arg Thr Tyr Val Asp Pro Phe Thr Tyr Glu Asp Pro Asn Gln Ala 
        595                 600                 605             


Val Arg Glu Phe Ala Lys Glu Ile Asp Ala Ser Cys Ile Lys Ile Glu 
    610                 615                 620                 


Lys Val Ile Gly Val Gly Glu Phe Gly Glu Val Cys Ser Gly Arg Leu 
625                 630                 635                 640 


Lys Val Pro Gly Lys Arg Glu Ile Cys Val Ala Ile Lys Thr Leu Lys 
                645                 650                 655     


Ala Gly Tyr Thr Asp Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser 
            660                 665                 670         


Ile Met Gly Gln Phe Asp His Pro Asn Ile Ile His Leu Glu Gly Val 
        675                 680                 685             


Val Thr Lys Cys Lys Pro Val Met Ile Ile Thr Glu Tyr Met Glu Asn 
    690                 695                 700                 


Gly Ser Leu Asp Ala Phe Leu Arg Lys Asn Asp Gly Arg Phe Thr Val 
705                 710                 715                 720 


Ile Gln Leu Val Gly Met Leu Arg Gly Ile Gly Ser Gly Met Lys Tyr 
                725                 730                 735     


Leu Ser Asp Met Ser Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile 
            740                 745                 750         


Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Met Ser 
        755                 760                 765             


Arg Val Leu Glu Asp Asp Pro Glu Ala Ala Tyr Thr Thr Arg Gly Gly 
    770                 775                 780                 


Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala Tyr Arg Lys 
785                 790                 795                 800 


Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu 
                805                 810                 815     


Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp 
            820                 825                 830         


Val Ile Lys Ala Ile Glu Glu Gly Tyr Arg Leu Pro Pro Pro Met Asp 
        835                 840                 845             


Cys Pro Ile Ala Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Glu 
    850                 855                 860                 


Arg Ser Asp Arg Pro Lys Phe Gly Gln Ile Val Asn Met Leu Asp Lys 
865                 870                 875                 880 


Leu Ile Arg Asn Pro Asn Ser Leu Lys Arg Thr Gly Thr Glu Ser Ser 
                885                 890                 895     


Arg Pro Asn Thr Ala Leu Leu Asp Pro Ser Ser Pro Glu Phe Ser Ala 
            900                 905                 910         


Val Val Ser Val Gly Asp Trp Leu Gln Ala Ile Lys Met Asp Arg Tyr 
        915                 920                 925             


Lys Asp Asn Phe Thr Ala Ala Gly Tyr Thr Thr Leu Glu Ala Val Val 
    930                 935                 940                 


His Val Asn Gln Glu Asp Leu Ala Arg Ile Gly Ile Thr Ala Ile Thr 
945                 950                 955                 960 


His Gln Asn Lys Ile Leu Ser Ser Val Gln Ala Met Arg Thr Gln Met 
                965                 970                 975     


Gln Gln Met His Gly Arg Met Val Pro Val 
            980                 985     


<210>  4816
<211>  949
<212>  PRT
<213>  Homo Sapiens

<400>  4816

Met Ala Gly Ile Phe Tyr Phe Ala Leu Phe Ser Cys Leu Phe Gly Ile 
1               5                   10                  15      


Cys Asp Ala Val Thr Gly Ser Arg Val Tyr Pro Ala Asn Glu Val Thr 
            20                  25                  30          


Leu Leu Asp Ser Arg Ser Val Gln Gly Glu Leu Gly Trp Ile Ala Ser 
        35                  40                  45              


Pro Leu Glu Gly Gly Trp Glu Glu Val Ser Ile Met Asp Glu Lys Asn 
    50                  55                  60                  


Thr Pro Ile Arg Thr Tyr Gln Val Cys Asn Val Met Glu Pro Ser Gln 
65                  70                  75                  80  


Asn Asn Trp Leu Arg Thr Asp Trp Ile Thr Arg Glu Gly Ala Gln Arg 
                85                  90                  95      


Val Tyr Ile Glu Ile Lys Phe Thr Leu Arg Asp Cys Asn Ser Leu Pro 
            100                 105                 110         


Gly Val Met Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Tyr Glu 
        115                 120                 125             


Ser Asp Asn Asp Lys Glu Arg Phe Ile Arg Glu Asn Gln Phe Val Lys 
    130                 135                 140                 


Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Val Asp Ile Gly 
145                 150                 155                 160 


Asp Arg Ile Met Lys Leu Asn Thr Glu Ile Arg Asp Val Gly Pro Leu 
                165                 170                 175     


Ser Lys Lys Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys Ile 
            180                 185                 190         


Ala Leu Val Ser Val Arg Val Phe Tyr Lys Lys Cys Pro Leu Thr Val 
        195                 200                 205             


Arg Asn Leu Ala Gln Phe Pro Asp Thr Ile Thr Gly Ala Asp Thr Ser 
    210                 215                 220                 


Ser Leu Val Glu Val Arg Gly Ser Cys Val Asn Asn Ser Glu Glu Lys 
225                 230                 235                 240 


Asp Val Pro Lys Met Tyr Cys Gly Ala Asp Gly Glu Trp Leu Val Pro 
                245                 250                 255     


Ile Gly Asn Cys Leu Cys Asn Ala Gly His Glu Glu Arg Ser Gly Glu 
            260                 265                 270         


Cys Gln Ala Cys Lys Ile Gly Tyr Tyr Lys Ala Leu Ser Thr Asp Ala 
        275                 280                 285             


Thr Cys Ala Lys Cys Pro Pro His Ser Tyr Ser Val Trp Glu Gly Ala 
    290                 295                 300                 


Thr Ser Cys Thr Cys Asp Arg Gly Phe Phe Arg Ala Asp Asn Asp Ala 
305                 310                 315                 320 


Ala Ser Met Pro Cys Thr Arg Pro Pro Ser Ala Pro Leu Asn Leu Ile 
                325                 330                 335     


Ser Asn Val Asn Glu Thr Ser Val Asn Leu Glu Trp Ser Ser Pro Gln 
            340                 345                 350         


Asn Thr Gly Gly Arg Gln Asp Ile Ser Tyr Asn Val Val Cys Lys Lys 
        355                 360                 365             


Cys Gly Ala Gly Asp Pro Ser Lys Cys Arg Pro Cys Gly Ser Gly Val 
    370                 375                 380                 


His Tyr Thr Pro Gln Gln Asn Gly Leu Lys Thr Thr Lys Val Ser Ile 
385                 390                 395                 400 


Thr Asp Leu Leu Ala His Thr Asn Tyr Thr Phe Glu Ile Trp Ala Val 
                405                 410                 415     


Asn Gly Val Ser Lys Tyr Asn Pro Asn Pro Asp Gln Ser Val Ser Val 
            420                 425                 430         


Thr Val Thr Thr Asn Gln Ala Ala Pro Ser Ser Ile Ala Leu Val Gln 
        435                 440                 445             


Ala Lys Glu Val Thr Arg Tyr Ser Val Ala Leu Ala Trp Leu Glu Pro 
    450                 455                 460                 


Asp Arg Pro Asn Gly Val Ile Leu Glu Tyr Glu Val Lys Tyr Tyr Glu 
465                 470                 475                 480 


Lys Asp Gln Asn Glu Arg Ser Tyr Arg Ile Val Arg Thr Ala Ala Arg 
                485                 490                 495     


Asn Thr Asp Ile Lys Gly Leu Asn Pro Leu Thr Ser Tyr Val Phe His 
            500                 505                 510         


Val Arg Ala Arg Thr Ala Ala Gly Tyr Gly Asp Phe Ser Glu Pro Leu 
        515                 520                 525             


Glu Val Thr Thr Asn Thr Val Pro Ser Arg Ile Ile Gly Asp Gly Ala 
    530                 535                 540                 


Asn Ser Thr Val Leu Leu Val Ser Val Ser Gly Ser Val Val Leu Val 
545                 550                 555                 560 


Val Ile Leu Ile Ala Ala Phe Val Ile Ser Arg Arg Arg Ser Lys Tyr 
                565                 570                 575     


Ser Lys Ala Lys Gln Glu Ala Asp Glu Glu Lys His Leu Asn Gln Gly 
            580                 585                 590         


Val Arg Thr Tyr Val Asp Pro Phe Thr Tyr Glu Asp Pro Asn Gln Ala 
        595                 600                 605             


Val Arg Glu Phe Ala Lys Glu Ile Asp Ala Ser Cys Ile Lys Ile Glu 
    610                 615                 620                 


Lys Val Ile Gly Val Gly Glu Phe Gly Glu Val Cys Ser Gly Arg Leu 
625                 630                 635                 640 


Lys Val Pro Gly Lys Arg Glu Ile Cys Val Ala Ile Lys Thr Leu Lys 
                645                 650                 655     


Ala Gly Tyr Thr Asp Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser 
            660                 665                 670         


Ile Met Gly Gln Phe Asp His Pro Asn Ile Ile His Leu Glu Gly Val 
        675                 680                 685             


Val Thr Lys Cys Lys Pro Val Met Ile Ile Thr Glu Tyr Met Glu Asn 
    690                 695                 700                 


Gly Ser Leu Asp Ala Phe Leu Arg Lys Asn Asp Gly Arg Phe Thr Val 
705                 710                 715                 720 


Ile Gln Leu Val Gly Met Leu Arg Gly Ile Gly Ser Gly Met Lys Tyr 
                725                 730                 735     


Leu Ser Asp Met Ser Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile 
            740                 745                 750         


Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Met Ser 
        755                 760                 765             


Arg Val Leu Glu Asp Asp Pro Glu Ala Ala Tyr Thr Thr Arg Gly Gly 
    770                 775                 780                 


Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala Tyr Arg Lys 
785                 790                 795                 800 


Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu 
                805                 810                 815     


Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp 
            820                 825                 830         


Val Ile Lys Ala Ile Glu Glu Gly Tyr Arg Leu Pro Pro Pro Met Asp 
        835                 840                 845             


Cys Pro Ile Ala Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Glu 
    850                 855                 860                 


Arg Ser Asp Arg Pro Lys Phe Gly Gln Ile Val Asn Met Leu Asp Lys 
865                 870                 875                 880 


Leu Ile Arg Asn Pro Asn Ser Leu Lys Arg Thr Gly Thr Glu Ser Ser 
                885                 890                 895     


Arg Pro Asn Thr Ala Leu Leu Asp Pro Ser Ser Pro Glu Phe Ser Ala 
            900                 905                 910         


Val Val Ser Val Gly Asp Trp Leu Gln Ala Ile Lys Met Asp Arg Tyr 
        915                 920                 925             


Lys Asp Asn Phe Thr Ala Ala Gly Tyr Thr Thr Leu Glu Ala Val Val 
    930                 935                 940                 


His Val Asn Gln Glu 
945                 


<210>  4817
<211>  126
<212>  PRT
<213>  Homo Sapiens

<400>  4817

Met Asp Glu Lys Asn Thr Pro Ile Arg Thr Tyr Gln Val Cys Asn Val 
1               5                   10                  15      


Met Glu Pro Ser Gln Asn Asn Trp Leu Arg Thr Asp Trp Ile Thr Arg 
            20                  25                  30          


Glu Gly Ala Gln Arg Val Tyr Ile Glu Ile Lys Phe Thr Leu Arg Asp 
        35                  40                  45              


Cys Asn Ser Leu Pro Gly Val Met Gly Thr Cys Lys Glu Thr Phe Asn 
    50                  55                  60                  


Leu Tyr Tyr Tyr Glu Ser Asp Asn Asp Lys Glu Arg Phe Ile Arg Glu 
65                  70                  75                  80  


Asn Gln Phe Val Lys Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr 
                85                  90                  95      


Gln Val Asp Ile Gly Asp Arg Ile Met Lys Leu Asn Thr Glu Ile Arg 
            100                 105                 110         


Asp Val Gly Pro Leu Ser Lys Lys Gly Phe Tyr Leu Ala Phe 
        115                 120                 125     


<210>  4818
<211>  189
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4818

Xaa Phe His Gly Ser Leu Ser Ser Thr His Phe Thr Cys Lys Ile Gly 
1               5                   10                  15      


Tyr Tyr Lys Ala Leu Ser Thr Asp Ala Thr Cys Ala Lys Cys Pro Pro 
            20                  25                  30          


His Ser Tyr Ser Val Trp Glu Gly Ala Thr Ser Cys Thr Cys Asp Arg 
        35                  40                  45              


Gly Phe Phe Arg Ala Asp Asn Asp Ala Ala Ser Met Pro Cys Thr Arg 
    50                  55                  60                  


Pro Pro Ser Ala Pro Leu Asn Leu Ile Ser Asn Val Asn Glu Thr Ser 
65                  70                  75                  80  


Val Asn Leu Glu Trp Ser Ser Pro Gln Asn Thr Gly Gly Arg Gln Asp 
                85                  90                  95      


Ile Ser Tyr Asn Val Val Cys Lys Lys Cys Gly Ala Gly Asp Pro Ser 
            100                 105                 110         


Lys Cys Arg Pro Cys Gly Ser Gly Val His Tyr Thr Pro Gln Gln Asn 
        115                 120                 125             


Gly Leu Lys Thr Thr Lys Val Ser Ile Thr Asp Leu Leu Ala His Thr 
    130                 135                 140                 


Asn Tyr Thr Phe Glu Ile Trp Ala Val Asn Gly Val Ser Lys Tyr Asn 
145                 150                 155                 160 


Pro Asn Pro Asp Gln Ser Val Ser Val Thr Val Thr Thr Asn Gln Ala 
                165                 170                 175     


Ala Pro Ser Ser Ile Ala Leu Val Gln Ala Lys Glu Val 
            180                 185                 


<210>  4819
<211>  279
<212>  PRT
<213>  Homo Sapiens

<400>  4819

Met Val Phe Gln Thr Arg Tyr Pro Ser Trp Ile Ile Leu Cys Tyr Ile 
1               5                   10                  15      


Trp Leu Leu Arg Phe Ala His Thr Gly Glu Ala Gln Ala Ala Lys Glu 
            20                  25                  30          


Val Leu Leu Leu Asp Ser Lys Ala Gln Gln Thr Glu Leu Glu Trp Ile 
        35                  40                  45              


Ser Ser Pro Pro Asn Gly Trp Glu Glu Ile Ser Gly Leu Asp Glu Asn 
    50                  55                  60                  


Tyr Thr Pro Ile Arg Thr Tyr Gln Val Cys Gln Val Met Glu Pro Asn 
65                  70                  75                  80  


Gln Asn Asn Trp Leu Arg Thr Asn Trp Ile Ser Lys Gly Asn Ala Gln 
                85                  90                  95      


Arg Ile Phe Val Glu Leu Lys Phe Thr Leu Arg Asp Cys Asn Ser Leu 
            100                 105                 110         


Pro Gly Val Leu Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Tyr 
        115                 120                 125             


Glu Thr Asp Tyr Asp Thr Gly Arg Asn Ile Arg Glu Asn Leu Tyr Val 
    130                 135                 140                 


Lys Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Gly Asp Leu 
145                 150                 155                 160 


Gly Glu Arg Lys Met Lys Leu Asn Thr Glu Val Arg Glu Ile Gly Pro 
                165                 170                 175     


Leu Ser Lys Lys Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys 
            180                 185                 190         


Ile Ala Leu Val Ser Val Lys Val Tyr Tyr Lys Lys Cys Trp Ser Ile 
        195                 200                 205             


Ile Glu Asn Leu Ala Ile Phe Pro Asp Thr Val Thr Gly Ser Glu Phe 
    210                 215                 220                 


Ser Ser Leu Val Glu Val Arg Gly Thr Cys Val Ser Ser Ala Glu Glu 
225                 230                 235                 240 


Glu Ala Glu Asn Ala Pro Arg Met His Cys Ser Ala Glu Gly Glu Trp 
                245                 250                 255     


Leu Val Pro Ile Gly Lys Cys Ile Cys Lys Ala Gly Tyr Gln Gln Lys 
            260                 265                 270         


Gly Asp Thr Cys Glu Arg Lys 
        275                 


<210>  4820
<211>  998
<212>  PRT
<213>  Homo Sapiens

<400>  4820

Met Val Phe Gln Thr Arg Tyr Pro Ser Trp Ile Ile Leu Cys Tyr Ile 
1               5                   10                  15      


Trp Leu Leu Arg Phe Ala His Thr Gly Glu Ala Gln Ala Ala Lys Glu 
            20                  25                  30          


Val Leu Leu Leu Asp Ser Lys Ala Gln Gln Thr Glu Leu Glu Trp Ile 
        35                  40                  45              


Ser Ser Pro Pro Asn Gly Trp Glu Glu Ile Ser Gly Leu Asp Glu Asn 
    50                  55                  60                  


Tyr Thr Pro Ile Arg Thr Tyr Gln Val Cys Gln Val Met Glu Pro Asn 
65                  70                  75                  80  


Gln Asn Asn Trp Leu Arg Thr Asn Trp Ile Ser Lys Gly Asn Ala Gln 
                85                  90                  95      


Arg Ile Phe Val Glu Leu Lys Phe Thr Leu Arg Asp Cys Asn Ser Leu 
            100                 105                 110         


Pro Gly Val Leu Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Tyr 
        115                 120                 125             


Glu Thr Asp Tyr Asp Thr Gly Arg Asn Ile Arg Glu Asn Leu Tyr Val 
    130                 135                 140                 


Lys Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Gly Asp Leu 
145                 150                 155                 160 


Gly Glu Arg Lys Met Lys Leu Asn Thr Glu Val Arg Glu Ile Gly Pro 
                165                 170                 175     


Leu Ser Lys Lys Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys 
            180                 185                 190         


Ile Ala Leu Val Ser Val Lys Val Tyr Tyr Lys Lys Cys Trp Ser Ile 
        195                 200                 205             


Ile Glu Asn Leu Ala Ile Phe Pro Asp Thr Val Thr Gly Ser Glu Phe 
    210                 215                 220                 


Ser Ser Leu Val Glu Val Arg Gly Thr Cys Val Ser Ser Ala Glu Glu 
225                 230                 235                 240 


Glu Ala Glu Asn Ala Pro Arg Met His Cys Ser Ala Glu Gly Glu Trp 
                245                 250                 255     


Leu Val Pro Ile Gly Lys Cys Ile Cys Lys Ala Gly Tyr Gln Gln Lys 
            260                 265                 270         


Gly Asp Thr Cys Glu Pro Cys Gly Arg Gly Phe Tyr Lys Ser Ser Ser 
        275                 280                 285             


Gln Asp Leu Gln Cys Ser Arg Cys Pro Thr His Ser Phe Ser Asp Lys 
    290                 295                 300                 


Glu Gly Ser Ser Arg Cys Glu Cys Glu Asp Gly Tyr Tyr Arg Ala Pro 
305                 310                 315                 320 


Ser Asp Pro Pro Tyr Val Ala Cys Thr Arg Pro Pro Ser Ala Pro Gln 
                325                 330                 335     


Asn Leu Ile Phe Asn Ile Asn Gln Thr Thr Val Ser Leu Glu Trp Ser 
            340                 345                 350         


Pro Pro Ala Asp Asn Gly Gly Arg Asn Asp Val Thr Tyr Arg Ile Leu 
        355                 360                 365             


Cys Lys Arg Cys Ser Trp Glu Gln Gly Glu Cys Val Pro Cys Gly Ser 
    370                 375                 380                 


Asn Ile Gly Tyr Met Pro Gln Gln Thr Gly Leu Glu Asp Asn Tyr Val 
385                 390                 395                 400 


Thr Val Met Asp Leu Leu Ala His Ala Asn Tyr Thr Phe Glu Val Glu 
                405                 410                 415     


Ala Val Asn Gly Val Ser Asp Leu Ser Arg Ser Gln Arg Leu Phe Ala 
            420                 425                 430         


Ala Val Ser Ile Thr Thr Gly Gln Ala Ala Pro Ser Gln Val Ser Gly 
        435                 440                 445             


Val Met Lys Glu Arg Val Leu Gln Arg Ser Val Glu Leu Ser Trp Gln 
    450                 455                 460                 


Glu Pro Glu His Pro Asn Gly Val Ile Thr Glu Tyr Glu Ile Lys Tyr 
465                 470                 475                 480 


Tyr Glu Lys Asp Gln Arg Glu Arg Thr Tyr Ser Thr Val Lys Thr Lys 
                485                 490                 495     


Ser Thr Ser Ala Ser Ile Asn Asn Leu Lys Pro Gly Thr Val Tyr Val 
            500                 505                 510         


Phe Gln Ile Arg Ala Phe Thr Ala Ala Gly Tyr Gly Asn Tyr Ser Pro 
        515                 520                 525             


Arg Leu Asp Val Ala Thr Leu Glu Glu Ala Thr Gly Lys Met Phe Glu 
    530                 535                 540                 


Ala Thr Ala Val Ser Ser Glu Gln Asn Pro Val Ile Ile Ile Ala Val 
545                 550                 555                 560 


Val Ala Val Ala Gly Thr Ile Ile Leu Val Phe Met Val Phe Gly Phe 
                565                 570                 575     


Ile Ile Gly Arg Arg His Cys Gly Tyr Ser Lys Ala Asp Gln Glu Gly 
            580                 585                 590         


Asp Glu Glu Leu Tyr Phe His Phe Lys Phe Pro Gly Thr Lys Thr Tyr 
        595                 600                 605             


Ile Asp Pro Glu Thr Tyr Glu Asp Pro Asn Arg Ala Val His Gln Phe 
    610                 615                 620                 


Ala Lys Glu Leu Asp Ala Ser Cys Ile Lys Ile Glu Arg Val Ile Gly 
625                 630                 635                 640 


Ala Gly Glu Phe Gly Glu Val Cys Ser Gly Arg Leu Lys Leu Pro Gly 
                645                 650                 655     


Lys Arg Asp Val Ala Val Ala Ile Lys Thr Leu Lys Val Gly Tyr Thr 
            660                 665                 670         


Glu Lys Gln Arg Arg Asp Phe Leu Cys Glu Ala Ser Ile Met Gly Gln 
        675                 680                 685             


Phe Asp His Pro Asn Val Val His Leu Glu Gly Val Val Thr Arg Gly 
    690                 695                 700                 


Lys Pro Val Met Ile Val Ile Glu Phe Met Glu Asn Gly Ala Leu Asp 
705                 710                 715                 720 


Ala Phe Leu Arg Lys His Asp Gly Gln Phe Thr Val Ile Gln Leu Val 
                725                 730                 735     


Gly Met Leu Arg Gly Ile Ala Ala Gly Met Arg Tyr Leu Ala Asp Met 
            740                 745                 750         


Gly Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser 
        755                 760                 765             


Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Val Ile Glu 
    770                 775                 780                 


Asp Asp Pro Glu Ala Val Tyr Thr Thr Thr Gly Gly Lys Ile Pro Val 
785                 790                 795                 800 


Arg Trp Thr Ala Pro Glu Ala Ile Gln Tyr Arg Lys Phe Thr Ser Ala 
                805                 810                 815     


Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu Val Met Ser Tyr 
            820                 825                 830         


Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp Val Ile Lys Ala 
        835                 840                 845             


Ile Glu Glu Gly Tyr Arg Leu Pro Ala Pro Met Asp Cys Pro Ala Gly 
    850                 855                 860                 


Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Glu Arg Ala Glu Arg 
865                 870                 875                 880 


Pro Lys Phe Glu Gln Ile Val Gly Ile Leu Asp Lys Met Ile Arg Asn 
                885                 890                 895     


Pro Asn Ser Leu Lys Thr Pro Leu Gly Thr Cys Ser Arg Pro Ile Ser 
            900                 905                 910         


Pro Leu Leu Asp Gln Asn Thr Pro Asp Phe Thr Thr Phe Cys Ser Val 
        915                 920                 925             


Gly Glu Trp Leu Gln Ala Ile Lys Met Glu Arg Tyr Lys Asp Asn Phe 
    930                 935                 940                 


Thr Ala Ala Gly Tyr Asn Ser Leu Glu Ser Val Ala Arg Met Thr Ile 
945                 950                 955                 960 


Glu Asp Val Met Ser Leu Gly Ile Thr Leu Val Gly His Gln Lys Lys 
                965                 970                 975     


Ile Met Ser Ser Ile Gln Thr Met Arg Ala Gln Met Leu His Leu His 
            980                 985                 990         


Gly Thr Gly Ile Gln Val 
        995             


<210>  4821
<211>  1005
<212>  PRT
<213>  Homo Sapiens

<400>  4821

Met Ala Pro Ala Arg Gly Arg Leu Pro Pro Ala Leu Trp Val Val Thr 
1               5                   10                  15      


Ala Ala Ala Ala Ala Ala Thr Cys Val Ser Ala Ala Arg Gly Glu Val 
            20                  25                  30          


Asn Leu Leu Asp Thr Ser Thr Ile His Gly Asp Trp Gly Trp Leu Thr 
        35                  40                  45              


Tyr Pro Ala His Gly Trp Asp Ser Ile Asn Glu Val Asp Glu Ser Phe 
    50                  55                  60                  


Gln Pro Ile His Thr Tyr Gln Val Cys Asn Val Met Ser Pro Asn Gln 
65                  70                  75                  80  


Asn Asn Trp Leu Arg Thr Ser Trp Val Pro Arg Asp Gly Ala Arg Arg 
                85                  90                  95      


Val Tyr Ala Glu Ile Lys Phe Thr Leu Arg Asp Cys Asn Ser Met Pro 
            100                 105                 110         


Gly Val Leu Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Leu Glu 
        115                 120                 125             


Ser Asp Arg Asp Leu Gly Ala Ser Thr Gln Glu Ser Gln Phe Leu Lys 
    130                 135                 140                 


Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr Gly Ala Asp Leu Gly 
145                 150                 155                 160 


Val Arg Arg Leu Lys Leu Asn Thr Glu Val Arg Ser Val Gly Pro Leu 
                165                 170                 175     


Ser Lys Arg Gly Phe Tyr Leu Ala Phe Gln Asp Ile Gly Ala Cys Leu 
            180                 185                 190         


Ala Ile Leu Ser Leu Arg Ile Tyr Tyr Lys Lys Cys Pro Ala Met Val 
        195                 200                 205             


Arg Asn Leu Ala Ala Phe Ser Glu Ala Val Thr Gly Ala Asp Ser Ser 
    210                 215                 220                 


Ser Leu Val Glu Val Arg Gly Gln Cys Val Arg His Ser Glu Glu Arg 
225                 230                 235                 240 


Asp Thr Pro Lys Met Tyr Cys Ser Ala Glu Gly Glu Trp Leu Val Pro 
                245                 250                 255     


Ile Gly Lys Cys Val Cys Ser Ala Gly Tyr Glu Glu Arg Arg Asp Ala 
            260                 265                 270         


Cys Val Ala Cys Glu Leu Gly Phe Tyr Lys Ser Ala Pro Gly Asp Gln 
        275                 280                 285             


Leu Cys Ala Arg Cys Pro Pro His Ser His Ser Ala Ala Pro Ala Ala 
    290                 295                 300                 


Gln Ala Cys His Cys Asp Leu Ser Tyr Tyr Arg Ala Ala Leu Asp Pro 
305                 310                 315                 320 


Pro Ser Ser Ala Cys Thr Arg Pro Pro Ser Ala Pro Val Asn Leu Ile 
                325                 330                 335     


Ser Ser Val Asn Gly Thr Ser Val Thr Leu Glu Trp Ala Pro Pro Leu 
            340                 345                 350         


Asp Pro Gly Gly Arg Ser Asp Ile Thr Tyr Asn Ala Val Cys Arg Arg 
        355                 360                 365             


Cys Pro Trp Ala Leu Ser Arg Cys Glu Ala Cys Gly Ser Gly Thr Arg 
    370                 375                 380                 


Phe Val Pro Gln Gln Thr Ser Leu Val Gln Ala Ser Leu Leu Val Ala 
385                 390                 395                 400 


Asn Leu Leu Ala His Met Asn Tyr Ser Phe Trp Ile Glu Ala Val Asn 
                405                 410                 415     


Gly Val Ser Asp Leu Ser Pro Glu Pro Arg Arg Ala Ala Val Val Asn 
            420                 425                 430         


Ile Thr Thr Asn Gln Ala Ala Pro Ser Gln Val Val Val Ile Arg Gln 
        435                 440                 445             


Glu Arg Ala Gly Gln Thr Ser Val Ser Leu Leu Trp Gln Glu Pro Glu 
    450                 455                 460                 


Gln Pro Asn Gly Ile Ile Leu Glu Tyr Glu Ile Lys Tyr Tyr Glu Lys 
465                 470                 475                 480 


Asp Lys Glu Met Gln Ser Tyr Ser Thr Leu Lys Ala Val Thr Thr Arg 
                485                 490                 495     


Ala Thr Val Ser Gly Leu Lys Pro Gly Thr Arg Tyr Val Phe Gln Val 
            500                 505                 510         


Arg Ala Arg Thr Ser Ala Gly Cys Gly Arg Phe Ser Gln Ala Met Glu 
        515                 520                 525             


Val Glu Thr Gly Lys Pro Arg Pro Arg Tyr Asp Thr Arg Thr Ile Val 
    530                 535                 540                 


Trp Ile Cys Leu Thr Leu Ile Thr Gly Leu Val Val Leu Leu Leu Leu 
545                 550                 555                 560 


Leu Ile Cys Lys Lys Arg His Cys Gly Tyr Ser Lys Ala Phe Gln Asp 
                565                 570                 575     


Ser Asp Glu Glu Lys Met His Tyr Gln Asn Gly Gln Ala Pro Pro Pro 
            580                 585                 590         


Val Phe Leu Pro Leu His His Pro Pro Gly Lys Leu Pro Glu Pro Gln 
        595                 600                 605             


Phe Tyr Ala Glu Pro His Thr Tyr Glu Glu Pro Gly Arg Ala Gly Arg 
    610                 615                 620                 


Ser Phe Thr Arg Glu Ile Glu Ala Ser Arg Ile His Ile Glu Lys Ile 
625                 630                 635                 640 


Ile Gly Ser Gly Asp Ser Gly Glu Val Cys Tyr Gly Arg Leu Arg Val 
                645                 650                 655     


Pro Gly Gln Arg Asp Val Pro Val Ala Ile Lys Ala Leu Lys Ala Gly 
            660                 665                 670         


Tyr Thr Glu Arg Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser Ile Met 
        675                 680                 685             


Gly Gln Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val Val Thr 
    690                 695                 700                 


Arg Gly Arg Leu Ala Met Ile Val Thr Glu Tyr Met Glu Asn Gly Ser 
705                 710                 715                 720 


Leu Asp Thr Phe Leu Arg Thr His Asp Gly Gln Phe Thr Ile Met Gln 
                725                 730                 735     


Leu Val Gly Met Leu Arg Gly Val Gly Ala Gly Met Arg Tyr Leu Ser 
            740                 745                 750         


Asp Leu Gly Tyr Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val 
        755                 760                 765             


Asp Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Val 
    770                 775                 780                 


Leu Glu Asp Asp Pro Asp Ala Ala Tyr Thr Thr Thr Gly Gly Lys Ile 
785                 790                 795                 800 


Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala Phe Arg Thr Phe Ser 
                805                 810                 815     


Ser Ala Ser Asp Val Trp Ser Phe Gly Val Val Met Trp Glu Val Leu 
            820                 825                 830         


Ala Tyr Gly Glu Arg Pro Tyr Trp Asn Met Thr Asn Arg Asp Val Ile 
        835                 840                 845             


Ser Ser Val Glu Glu Gly Tyr Arg Leu Pro Ala Pro Met Gly Cys Pro 
    850                 855                 860                 


His Ala Leu His Gln Leu Met Leu Asp Cys Trp His Lys Asp Arg Ala 
865                 870                 875                 880 


Gln Arg Pro Arg Phe Ser Gln Ile Val Ser Val Leu Asp Ala Leu Ile 
                885                 890                 895     


Arg Ser Pro Glu Ser Leu Arg Ala Thr Ala Thr Val Ser Arg Cys Pro 
            900                 905                 910         


Pro Pro Ala Phe Val Arg Ser Cys Phe Asp Leu Arg Gly Gly Ser Gly 
        915                 920                 925             


Gly Gly Gly Gly Leu Thr Val Gly Asp Trp Leu Asp Ser Ile Arg Met 
    930                 935                 940                 


Gly Arg Tyr Arg Asp His Phe Ala Ala Gly Gly Tyr Ser Ser Leu Gly 
945                 950                 955                 960 


Met Val Leu Arg Met Asn Ala Gln Asp Val Arg Ala Leu Gly Ile Thr 
                965                 970                 975     


Leu Met Gly His Gln Lys Lys Ile Leu Gly Ser Ile Gln Thr Met Arg 
            980                 985                 990         


Ala Gln Leu Thr Ser Thr Gln Gly  Pro Arg Arg His Leu  
        995                 1000                 1005 


<210>  4822
<211>  495
<212>  PRT
<213>  Homo Sapiens

<400>  4822

Met Ala Pro Ala Arg Gly Arg Leu Pro Pro Ala Leu Trp Val Val Thr 
1               5                   10                  15      


Ala Ala Ala Ala Ala Ala Thr Cys Val Ser Ala Ala Arg Gly Glu Val 
            20                  25                  30          


Asn Leu Leu Asp Thr Ser Thr Ile His Gly Asp Trp Gly Trp Leu Thr 
        35                  40                  45              


Tyr Pro Ala His Gly Trp Asp Ser Ile Asn Glu Val Asp Glu Ser Phe 
    50                  55                  60                  


Gln Pro Ile His Thr Tyr Gln Val Cys Asn Val Met Ser Pro Asn Gln 
65                  70                  75                  80  


Asn Asn Trp Leu Arg Thr Ser Trp Val Pro Arg Asp Gly Ala Arg Arg 
                85                  90                  95      


Val Tyr Ala Glu Ile Lys Phe Thr Leu Arg Asp Cys Asn Ser Met Pro 
            100                 105                 110         


Gly Val Leu Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Leu Glu 
        115                 120                 125             


Ser Asp Arg Asp Leu Gly Ala Ser Thr Gln Glu Ser Gln Phe Leu Lys 
    130                 135                 140                 


Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr Gly Ala Asp Leu Gly 
145                 150                 155                 160 


Val Arg Arg Leu Lys Leu Asn Thr Glu Val Arg Ser Val Gly Pro Leu 
                165                 170                 175     


Ser Lys Arg Gly Phe Tyr Leu Ala Phe Gln Asp Ile Gly Ala Cys Leu 
            180                 185                 190         


Ala Ile Leu Ser Leu Arg Ile Tyr Tyr Lys Lys Cys Pro Ala Met Val 
        195                 200                 205             


Arg Asn Leu Ala Ala Phe Ser Glu Ala Val Thr Gly Ala Asp Ser Ser 
    210                 215                 220                 


Ser Leu Val Glu Val Arg Gly Gln Cys Val Arg His Ser Glu Glu Arg 
225                 230                 235                 240 


Asp Thr Pro Lys Met Tyr Cys Ser Ala Glu Gly Glu Trp Leu Val Pro 
                245                 250                 255     


Ile Gly Lys Cys Val Cys Ser Ala Gly Tyr Glu Glu Arg Arg Asp Ala 
            260                 265                 270         


Cys Val Ala Cys Glu Leu Gly Phe Tyr Lys Ser Ala Pro Gly Asp Gln 
        275                 280                 285             


Leu Cys Ala Arg Cys Pro Pro His Ser His Ser Ala Ala Pro Ala Ala 
    290                 295                 300                 


Gln Ala Cys His Cys Asp Leu Ser Tyr Tyr Arg Ala Ala Leu Asp Pro 
305                 310                 315                 320 


Pro Ser Ser Ala Cys Thr Arg Pro Pro Ser Ala Pro Val Asn Leu Ile 
                325                 330                 335     


Ser Ser Val Asn Gly Thr Ser Val Thr Leu Glu Trp Ala Pro Pro Leu 
            340                 345                 350         


Asp Pro Gly Gly Arg Ser Asp Ile Thr Tyr Asn Ala Val Cys Arg Arg 
        355                 360                 365             


Cys Pro Trp Ala Leu Ser Arg Cys Glu Ala Cys Gly Ser Gly Thr Arg 
    370                 375                 380                 


Phe Val Pro Gln Gln Thr Ser Leu Val Gln Ala Ser Leu Leu Val Ala 
385                 390                 395                 400 


Asn Leu Leu Ala His Met Asn Tyr Ser Phe Trp Ile Glu Ala Val Asn 
                405                 410                 415     


Gly Val Ser Asp Leu Ser Pro Glu Pro Arg Arg Ala Ala Val Val Asn 
            420                 425                 430         


Ile Thr Thr Asn Gln Ala Gly Arg Arg Arg Asn Ser Val Pro Gln Arg 
        435                 440                 445             


Pro Gly Pro Pro Ala Ser Pro Ala Ser Asp Pro Ser Arg Asp Gln Ser 
    450                 455                 460                 


Ser Ala Gly Asp Val Leu Trp Ala Phe Arg Gln Val Pro Leu Trp Pro 
465                 470                 475                 480 


Cys Ala Pro His Gln Asp Pro Glu Leu Glu Ala Leu His Cys Leu 
                485                 490                 495 


<210>  4823
<211>  986
<212>  PRT
<213>  Homo Sapiens

<400>  4823

Met Ala Leu Arg Arg Leu Gly Ala Ala Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Ala Ala Val Glu Glu Thr Leu Met Asp Ser Thr Thr Ala Thr Ala Glu 
            20                  25                  30          


Leu Gly Trp Met Val His Pro Pro Ser Gly Trp Glu Glu Val Ser Gly 
        35                  40                  45              


Tyr Asp Glu Asn Met Asn Thr Ile Arg Thr Tyr Gln Val Cys Asn Val 
    50                  55                  60                  


Phe Glu Ser Ser Gln Asn Asn Trp Leu Arg Thr Lys Phe Ile Arg Arg 
65                  70                  75                  80  


Arg Gly Ala His Arg Ile His Val Glu Met Lys Phe Ser Val Arg Asp 
                85                  90                  95      


Cys Ser Ser Ile Pro Ser Val Pro Gly Ser Cys Lys Glu Thr Phe Asn 
            100                 105                 110         


Leu Tyr Tyr Tyr Glu Ala Asp Phe Asp Ser Ala Thr Lys Thr Phe Pro 
        115                 120                 125             


Asn Trp Met Glu Asn Pro Trp Val Lys Val Asp Thr Ile Ala Ala Asp 
    130                 135                 140                 


Glu Ser Phe Ser Gln Val Asp Leu Gly Gly Arg Val Met Lys Ile Asn 
145                 150                 155                 160 


Thr Glu Val Arg Ser Phe Gly Pro Val Ser Arg Ser Gly Phe Tyr Leu 
                165                 170                 175     


Ala Phe Gln Asp Tyr Gly Gly Cys Met Ser Leu Ile Ala Val Arg Val 
            180                 185                 190         


Phe Tyr Arg Lys Cys Pro Arg Ile Ile Gln Asn Gly Ala Ile Phe Gln 
        195                 200                 205             


Glu Thr Leu Ser Gly Ala Glu Ser Thr Ser Leu Val Ala Ala Arg Gly 
    210                 215                 220                 


Ser Cys Ile Ala Asn Ala Glu Glu Val Asp Val Pro Ile Lys Leu Tyr 
225                 230                 235                 240 


Cys Asn Gly Asp Gly Glu Trp Leu Val Pro Ile Gly Arg Cys Met Cys 
                245                 250                 255     


Lys Ala Gly Phe Glu Ala Val Glu Asn Gly Thr Val Cys Arg Gly Cys 
            260                 265                 270         


Pro Ser Gly Thr Phe Lys Ala Asn Gln Gly Asp Glu Ala Cys Thr His 
        275                 280                 285             


Cys Pro Ile Asn Ser Arg Thr Thr Ser Glu Gly Ala Thr Asn Cys Val 
    290                 295                 300                 


Cys Arg Asn Gly Tyr Tyr Arg Ala Asp Leu Asp Pro Leu Asp Met Pro 
305                 310                 315                 320 


Cys Thr Thr Ile Pro Ser Ala Pro Gln Ala Val Ile Ser Ser Val Asn 
                325                 330                 335     


Glu Thr Ser Leu Met Leu Glu Trp Thr Pro Pro Arg Asp Ser Gly Gly 
            340                 345                 350         


Arg Glu Asp Leu Val Tyr Asn Ile Ile Cys Lys Ser Cys Gly Ser Gly 
        355                 360                 365             


Arg Gly Ala Cys Thr Arg Cys Gly Asp Asn Val Gln Tyr Ala Pro Arg 
    370                 375                 380                 


Gln Leu Gly Leu Thr Glu Pro Arg Ile Tyr Ile Ser Asp Leu Leu Ala 
385                 390                 395                 400 


His Thr Gln Tyr Thr Phe Glu Ile Gln Ala Val Asn Gly Val Thr Asp 
                405                 410                 415     


Gln Ser Pro Phe Ser Pro Gln Phe Ala Ser Val Asn Ile Thr Thr Asn 
            420                 425                 430         


Gln Ala Ala Pro Ser Ala Val Ser Ile Met His Gln Val Ser Arg Thr 
        435                 440                 445             


Val Asp Ser Ile Thr Leu Ser Trp Ser Gln Pro Asp Gln Pro Asn Gly 
    450                 455                 460                 


Val Ile Leu Asp Tyr Glu Leu Gln Tyr Tyr Glu Lys Glu Leu Ser Glu 
465                 470                 475                 480 


Tyr Asn Ala Thr Ala Ile Lys Ser Pro Thr Asn Thr Val Thr Val Gln 
                485                 490                 495     


Gly Leu Lys Ala Gly Ala Ile Tyr Val Phe Gln Val Arg Ala Arg Thr 
            500                 505                 510         


Val Ala Gly Tyr Gly Arg Tyr Ser Gly Lys Met Tyr Phe Gln Thr Met 
        515                 520                 525             


Thr Glu Ala Glu Tyr Gln Thr Ser Ile Gln Glu Lys Leu Pro Leu Ile 
    530                 535                 540                 


Ile Gly Ser Ser Ala Ala Gly Leu Val Phe Leu Ile Ala Val Val Val 
545                 550                 555                 560 


Ile Ala Ile Val Cys Asn Arg Arg Gly Phe Glu Arg Ala Asp Ser Glu 
                565                 570                 575     


Tyr Thr Asp Lys Leu Gln His Tyr Thr Ser Gly His Met Thr Pro Gly 
            580                 585                 590         


Met Lys Ile Tyr Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala 
        595                 600                 605             


Val Arg Glu Phe Ala Lys Glu Ile Asp Ile Ser Cys Val Lys Ile Glu 
    610                 615                 620                 


Gln Val Ile Gly Ala Gly Glu Phe Gly Glu Val Cys Ser Gly His Leu 
625                 630                 635                 640 


Lys Leu Pro Gly Lys Arg Glu Ile Phe Val Ala Ile Lys Thr Leu Lys 
                645                 650                 655     


Ser Gly Tyr Thr Glu Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser 
            660                 665                 670         


Ile Met Gly Gln Phe Asp His Pro Asn Val Ile His Leu Glu Gly Val 
        675                 680                 685             


Val Thr Lys Ser Thr Pro Val Met Ile Ile Thr Glu Phe Met Glu Asn 
    690                 695                 700                 


Gly Ser Leu Asp Ser Phe Leu Arg Gln Asn Asp Gly Gln Phe Thr Val 
705                 710                 715                 720 


Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys Tyr 
                725                 730                 735     


Leu Ala Asp Met Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile 
            740                 745                 750         


Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser 
        755                 760                 765             


Arg Phe Leu Glu Asp Asp Thr Ser Asp Pro Thr Tyr Thr Ser Ala Leu 
    770                 775                 780                 


Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Gln Tyr 
785                 790                 795                 800 


Arg Lys Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met 
                805                 810                 815     


Trp Glu Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Thr Asn 
            820                 825                 830         


Gln Asp Val Ile Asn Ala Ile Glu Gln Asp Tyr Arg Leu Pro Pro Pro 
        835                 840                 845             


Met Asp Cys Pro Ser Ala Leu His Gln Leu Met Leu Asp Cys Trp Gln 
    850                 855                 860                 


Lys Asp Arg Asn His Arg Pro Lys Phe Gly Gln Ile Val Asn Thr Leu 
865                 870                 875                 880 


Asp Lys Met Ile Arg Asn Pro Asn Ser Leu Lys Ala Met Ala Pro Leu 
                885                 890                 895     


Ser Ser Gly Ile Asn Leu Pro Leu Leu Asp Arg Thr Ile Pro Asp Tyr 
            900                 905                 910         


Thr Ser Phe Asn Thr Val Asp Glu Trp Leu Glu Ala Ile Lys Met Gly 
        915                 920                 925             


Gln Tyr Lys Glu Ser Phe Ala Asn Ala Gly Phe Thr Ser Phe Asp Val 
    930                 935                 940                 


Val Ser Gln Met Met Met Glu Asp Ile Leu Arg Val Gly Val Thr Leu 
945                 950                 955                 960 


Ala Gly His Gln Lys Lys Ile Leu Asn Ser Ile Gln Val Met Arg Ala 
                965                 970                 975     


Gln Met Asn Gln Ile Gln Ser Val Glu Val 
            980                 985     


<210>  4824
<211>  1055
<212>  PRT
<213>  Homo Sapiens

<400>  4824

Met Ala Leu Arg Arg Leu Gly Ala Ala Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Ala Ala Val Glu Glu Thr Leu Met Asp Ser Thr Thr Ala Thr Ala Glu 
            20                  25                  30          


Leu Gly Trp Met Val His Pro Pro Ser Gly Trp Glu Glu Val Ser Gly 
        35                  40                  45              


Tyr Asp Glu Asn Met Asn Thr Ile Arg Thr Tyr Gln Val Cys Asn Val 
    50                  55                  60                  


Phe Glu Ser Ser Gln Asn Asn Trp Leu Arg Thr Lys Phe Ile Arg Arg 
65                  70                  75                  80  


Arg Gly Ala His Arg Ile His Val Glu Met Lys Phe Ser Val Arg Asp 
                85                  90                  95      


Cys Ser Ser Ile Pro Ser Val Pro Gly Ser Cys Lys Glu Thr Phe Asn 
            100                 105                 110         


Leu Tyr Tyr Tyr Glu Ala Asp Phe Asp Ser Ala Thr Lys Thr Phe Pro 
        115                 120                 125             


Asn Trp Met Glu Asn Pro Trp Val Lys Val Asp Thr Ile Ala Ala Asp 
    130                 135                 140                 


Glu Ser Phe Ser Gln Val Asp Leu Gly Gly Arg Val Met Lys Ile Asn 
145                 150                 155                 160 


Thr Glu Val Arg Ser Phe Gly Pro Val Ser Arg Ser Gly Phe Tyr Leu 
                165                 170                 175     


Ala Phe Gln Asp Tyr Gly Gly Cys Met Ser Leu Ile Ala Val Arg Val 
            180                 185                 190         


Phe Tyr Arg Lys Cys Pro Arg Ile Ile Gln Asn Gly Ala Ile Phe Gln 
        195                 200                 205             


Glu Thr Leu Ser Gly Ala Glu Ser Thr Ser Leu Val Ala Ala Arg Gly 
    210                 215                 220                 


Ser Cys Ile Ala Asn Ala Glu Glu Val Asp Val Pro Ile Lys Leu Tyr 
225                 230                 235                 240 


Cys Asn Gly Asp Gly Glu Trp Leu Val Pro Ile Gly Arg Cys Met Cys 
                245                 250                 255     


Lys Ala Gly Phe Glu Ala Val Glu Asn Gly Thr Val Cys Arg Gly Cys 
            260                 265                 270         


Pro Ser Gly Thr Phe Lys Ala Asn Gln Gly Asp Glu Ala Cys Thr His 
        275                 280                 285             


Cys Pro Ile Asn Ser Arg Thr Thr Ser Glu Gly Ala Thr Asn Cys Val 
    290                 295                 300                 


Cys Arg Asn Gly Tyr Tyr Arg Ala Asp Leu Asp Pro Leu Asp Met Pro 
305                 310                 315                 320 


Cys Thr Thr Ile Pro Ser Ala Pro Gln Ala Val Ile Ser Ser Val Asn 
                325                 330                 335     


Glu Thr Ser Leu Met Leu Glu Trp Thr Pro Pro Arg Asp Ser Gly Gly 
            340                 345                 350         


Arg Glu Asp Leu Val Tyr Asn Ile Ile Cys Lys Ser Cys Gly Ser Gly 
        355                 360                 365             


Arg Gly Ala Cys Thr Arg Cys Gly Asp Asn Val Gln Tyr Ala Pro Arg 
    370                 375                 380                 


Gln Leu Gly Leu Thr Glu Pro Arg Ile Tyr Ile Ser Asp Leu Leu Ala 
385                 390                 395                 400 


His Thr Gln Tyr Thr Phe Glu Ile Gln Ala Val Asn Gly Val Thr Asp 
                405                 410                 415     


Gln Ser Pro Phe Ser Pro Gln Phe Ala Ser Val Asn Ile Thr Thr Asn 
            420                 425                 430         


Gln Ala Ala Pro Ser Ala Val Ser Ile Met His Gln Val Ser Arg Thr 
        435                 440                 445             


Val Asp Ser Ile Thr Leu Ser Trp Ser Gln Pro Asp Gln Pro Asn Gly 
    450                 455                 460                 


Val Ile Leu Asp Tyr Glu Leu Gln Tyr Tyr Glu Lys Glu Leu Ser Glu 
465                 470                 475                 480 


Tyr Asn Ala Thr Ala Ile Lys Ser Pro Thr Asn Thr Val Thr Val Gln 
                485                 490                 495     


Gly Leu Lys Ala Gly Ala Ile Tyr Val Phe Gln Val Arg Ala Arg Thr 
            500                 505                 510         


Val Ala Gly Tyr Gly Arg Tyr Ser Gly Lys Met Tyr Phe Gln Thr Met 
        515                 520                 525             


Thr Glu Ala Glu Tyr Gln Thr Ser Ile Gln Glu Lys Leu Pro Leu Ile 
    530                 535                 540                 


Ile Gly Ser Ser Ala Ala Gly Leu Val Phe Leu Ile Ala Val Val Val 
545                 550                 555                 560 


Ile Ala Ile Val Cys Asn Arg Arg Gly Phe Glu Arg Ala Asp Ser Glu 
                565                 570                 575     


Tyr Thr Asp Lys Leu Gln His Tyr Thr Ser Gly His Met Thr Pro Gly 
            580                 585                 590         


Met Lys Ile Tyr Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala 
        595                 600                 605             


Val Arg Glu Phe Ala Lys Glu Ile Asp Ile Ser Cys Val Lys Ile Glu 
    610                 615                 620                 


Gln Val Ile Gly Ala Gly Glu Phe Gly Glu Val Cys Ser Gly His Leu 
625                 630                 635                 640 


Lys Leu Pro Gly Lys Arg Glu Ile Phe Val Ala Ile Lys Thr Leu Lys 
                645                 650                 655     


Ser Gly Tyr Thr Glu Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser 
            660                 665                 670         


Ile Met Gly Gln Phe Asp His Pro Asn Val Ile His Leu Glu Gly Val 
        675                 680                 685             


Val Thr Lys Ser Thr Pro Val Met Ile Ile Thr Glu Phe Met Glu Asn 
    690                 695                 700                 


Gly Ser Leu Asp Ser Phe Leu Arg Gln Asn Asp Gly Gln Phe Thr Val 
705                 710                 715                 720 


Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys Tyr 
                725                 730                 735     


Leu Ala Asp Met Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile 
            740                 745                 750         


Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser 
        755                 760                 765             


Arg Phe Leu Glu Asp Asp Thr Ser Asp Pro Thr Tyr Thr Ser Ala Leu 
    770                 775                 780                 


Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Gln Tyr 
785                 790                 795                 800 


Arg Lys Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met 
                805                 810                 815     


Trp Glu Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Thr Asn 
            820                 825                 830         


Gln Asp Val Ile Asn Ala Ile Glu Gln Asp Tyr Arg Leu Pro Pro Pro 
        835                 840                 845             


Met Asp Cys Pro Ser Ala Leu His Gln Leu Met Leu Asp Cys Trp Gln 
    850                 855                 860                 


Lys Asp Arg Asn His Arg Pro Lys Phe Gly Gln Ile Val Asn Thr Leu 
865                 870                 875                 880 


Asp Lys Met Ile Arg Asn Pro Asn Ser Leu Lys Ala Met Ala Pro Leu 
                885                 890                 895     


Ser Ser Gly Ile Asn Leu Pro Leu Leu Asp Arg Thr Ile Pro Asp Tyr 
            900                 905                 910         


Thr Ser Phe Asn Thr Val Asp Glu Trp Leu Glu Ala Ile Lys Met Gly 
        915                 920                 925             


Gln Tyr Lys Glu Ser Phe Ala Asn Ala Gly Phe Thr Ser Phe Asp Val 
    930                 935                 940                 


Val Ser Gln Met Met Met Glu Asp Ile Leu Arg Val Gly Val Thr Leu 
945                 950                 955                 960 


Ala Gly His Gln Lys Lys Ile Leu Asn Ser Ile Gln Val Met Arg Ala 
                965                 970                 975     


Gln Met Asn Gln Ile Gln Ser Val Glu Gly Gln Pro Leu Ala Arg Arg 
            980                 985                 990         


Pro Arg Ala Thr Gly Arg Thr Lys  Arg Cys Gln Pro Arg  Asp Val Thr 
        995                 1000                 1005             


Lys Lys  Thr Cys Asn Ser Asn  Asp Gly Lys Lys Lys  Gly Met Gly 
    1010                 1015                 1020             


Lys Lys  Lys Thr Asp Pro Gly  Arg Gly Arg Glu Ile  Gln Gly Ile 
    1025                 1030                 1035             


Phe Phe  Lys Glu Asp Ser His  Lys Glu Ser Asn Asp  Cys Ser Cys 
    1040                 1045                 1050             


Gly Gly  
    1055 


<210>  4825
<211>  987
<212>  PRT
<213>  Homo Sapiens

<400>  4825

Met Ala Leu Arg Arg Leu Gly Ala Ala Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Ala Ala Val Glu Glu Thr Leu Met Asp Ser Thr Thr Ala Thr Ala Glu 
            20                  25                  30          


Leu Gly Trp Met Val His Pro Pro Ser Gly Trp Glu Glu Val Ser Gly 
        35                  40                  45              


Tyr Asp Glu Asn Met Asn Thr Ile Arg Thr Tyr Gln Val Cys Asn Val 
    50                  55                  60                  


Phe Glu Ser Ser Gln Asn Asn Trp Leu Arg Thr Lys Phe Ile Arg Arg 
65                  70                  75                  80  


Arg Gly Ala His Arg Ile His Val Glu Met Lys Phe Ser Val Arg Asp 
                85                  90                  95      


Cys Ser Ser Ile Pro Ser Val Pro Gly Ser Cys Lys Glu Thr Phe Asn 
            100                 105                 110         


Leu Tyr Tyr Tyr Glu Ala Asp Phe Asp Ser Ala Thr Lys Thr Phe Pro 
        115                 120                 125             


Asn Trp Met Glu Asn Pro Trp Val Lys Val Asp Thr Ile Ala Ala Asp 
    130                 135                 140                 


Glu Ser Phe Ser Gln Val Asp Leu Gly Gly Arg Val Met Lys Ile Asn 
145                 150                 155                 160 


Thr Glu Val Arg Ser Phe Gly Pro Val Ser Arg Ser Gly Phe Tyr Leu 
                165                 170                 175     


Ala Phe Gln Asp Tyr Gly Gly Cys Met Ser Leu Ile Ala Val Arg Val 
            180                 185                 190         


Phe Tyr Arg Lys Cys Pro Arg Ile Ile Gln Asn Gly Ala Ile Phe Gln 
        195                 200                 205             


Glu Thr Leu Ser Gly Ala Glu Ser Thr Ser Leu Val Ala Ala Arg Gly 
    210                 215                 220                 


Ser Cys Ile Ala Asn Ala Glu Glu Val Asp Val Pro Ile Lys Leu Tyr 
225                 230                 235                 240 


Cys Asn Gly Asp Gly Glu Trp Leu Val Pro Ile Gly Arg Cys Met Cys 
                245                 250                 255     


Lys Ala Gly Phe Glu Ala Val Glu Asn Gly Thr Val Cys Arg Gly Cys 
            260                 265                 270         


Pro Ser Gly Thr Phe Lys Ala Asn Gln Gly Asp Glu Ala Cys Thr His 
        275                 280                 285             


Cys Pro Ile Asn Ser Arg Thr Thr Ser Glu Gly Ala Thr Asn Cys Val 
    290                 295                 300                 


Cys Arg Asn Gly Tyr Tyr Arg Ala Asp Leu Asp Pro Leu Asp Met Pro 
305                 310                 315                 320 


Cys Thr Thr Ile Pro Ser Ala Pro Gln Ala Val Ile Ser Ser Val Asn 
                325                 330                 335     


Glu Thr Ser Leu Met Leu Glu Trp Thr Pro Pro Arg Asp Ser Gly Gly 
            340                 345                 350         


Arg Glu Asp Leu Val Tyr Asn Ile Ile Cys Lys Ser Cys Gly Ser Gly 
        355                 360                 365             


Arg Gly Ala Cys Thr Arg Cys Gly Asp Asn Val Gln Tyr Ala Pro Arg 
    370                 375                 380                 


Gln Leu Gly Leu Thr Glu Pro Arg Ile Tyr Ile Ser Asp Leu Leu Ala 
385                 390                 395                 400 


His Thr Gln Tyr Thr Phe Glu Ile Gln Ala Val Asn Gly Val Thr Asp 
                405                 410                 415     


Gln Ser Pro Phe Ser Pro Gln Phe Ala Ser Val Asn Ile Thr Thr Asn 
            420                 425                 430         


Gln Ala Ala Pro Ser Ala Val Ser Ile Met His Gln Val Ser Arg Thr 
        435                 440                 445             


Val Asp Ser Ile Thr Leu Ser Trp Ser Gln Pro Asp Gln Pro Asn Gly 
    450                 455                 460                 


Val Ile Leu Asp Tyr Glu Leu Gln Tyr Tyr Glu Lys Glu Leu Ser Glu 
465                 470                 475                 480 


Tyr Asn Ala Thr Ala Ile Lys Ser Pro Thr Asn Thr Val Thr Val Gln 
                485                 490                 495     


Gly Leu Lys Ala Gly Ala Ile Tyr Val Phe Gln Val Arg Ala Arg Thr 
            500                 505                 510         


Val Ala Gly Tyr Gly Arg Tyr Ser Gly Lys Met Tyr Phe Gln Thr Met 
        515                 520                 525             


Thr Glu Ala Glu Tyr Gln Thr Ser Ile Gln Glu Lys Leu Pro Leu Ile 
    530                 535                 540                 


Ile Gly Ser Ser Ala Ala Gly Leu Val Phe Leu Ile Ala Val Val Val 
545                 550                 555                 560 


Ile Ala Ile Val Cys Asn Arg Arg Arg Gly Phe Glu Arg Ala Asp Ser 
                565                 570                 575     


Glu Tyr Thr Asp Lys Leu Gln His Tyr Thr Ser Gly His Met Thr Pro 
            580                 585                 590         


Gly Met Lys Ile Tyr Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu 
        595                 600                 605             


Ala Val Arg Glu Phe Ala Lys Glu Ile Asp Ile Ser Cys Val Lys Ile 
    610                 615                 620                 


Glu Gln Val Ile Gly Ala Gly Glu Phe Gly Glu Val Cys Ser Gly His 
625                 630                 635                 640 


Leu Lys Leu Pro Gly Lys Arg Glu Ile Phe Val Ala Ile Lys Thr Leu 
                645                 650                 655     


Lys Ser Gly Tyr Thr Glu Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala 
            660                 665                 670         


Ser Ile Met Gly Gln Phe Asp His Pro Asn Val Ile His Leu Glu Gly 
        675                 680                 685             


Val Val Thr Lys Ser Thr Pro Val Met Ile Ile Thr Glu Phe Met Glu 
    690                 695                 700                 


Asn Gly Ser Leu Asp Ser Phe Leu Arg Gln Asn Asp Gly Gln Phe Thr 
705                 710                 715                 720 


Val Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys 
                725                 730                 735     


Tyr Leu Ala Asp Met Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn 
            740                 745                 750         


Ile Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu 
        755                 760                 765             


Ser Arg Phe Leu Glu Asp Asp Thr Ser Asp Pro Thr Tyr Thr Ser Ala 
    770                 775                 780                 


Leu Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Gln 
785                 790                 795                 800 


Tyr Arg Lys Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val 
                805                 810                 815     


Met Trp Glu Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Thr 
            820                 825                 830         


Asn Gln Asp Val Ile Asn Ala Ile Glu Gln Asp Tyr Arg Leu Pro Pro 
        835                 840                 845             


Pro Met Asp Cys Pro Ser Ala Leu His Gln Leu Met Leu Asp Cys Trp 
    850                 855                 860                 


Gln Lys Asp Arg Asn His Arg Pro Lys Phe Gly Gln Ile Val Asn Thr 
865                 870                 875                 880 


Leu Asp Lys Met Ile Arg Asn Pro Asn Ser Leu Lys Ala Met Ala Pro 
                885                 890                 895     


Leu Ser Ser Gly Ile Asn Leu Pro Leu Leu Asp Arg Thr Ile Pro Asp 
            900                 905                 910         


Tyr Thr Ser Phe Asn Thr Val Asp Glu Trp Leu Glu Ala Ile Lys Met 
        915                 920                 925             


Gly Gln Tyr Lys Glu Ser Phe Ala Asn Ala Gly Phe Thr Ser Phe Asp 
    930                 935                 940                 


Val Val Ser Gln Met Met Met Glu Asp Ile Leu Arg Val Gly Val Thr 
945                 950                 955                 960 


Leu Ala Gly His Gln Lys Lys Ile Leu Asn Ser Ile Gln Val Met Arg 
                965                 970                 975     


Ala Gln Met Asn Gln Ile Gln Ser Val Glu Val 
            980                 985         


<210>  4826
<211>  482
<212>  PRT
<213>  Homo Sapiens

<400>  4826

Met Ala Leu Arg Arg Leu Gly Ala Ala Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Ala Ala Val Glu Glu Thr Leu Met Asp Ser Thr Thr Ala Thr Ala Glu 
            20                  25                  30          


Leu Gly Trp Met Val His Pro Pro Ser Gly Trp Glu Glu Val Ser Gly 
        35                  40                  45              


Tyr Asp Glu Asn Met Asn Thr Ile Arg Thr Tyr Gln Val Cys Asn Val 
    50                  55                  60                  


Phe Glu Ser Ser Gln Asn Asn Trp Leu Arg Thr Lys Phe Ile Arg Arg 
65                  70                  75                  80  


Arg Gly Ala His Arg Ile His Val Glu Met Lys Phe Ser Val Arg Asp 
                85                  90                  95      


Cys Ser Ser Ile Pro Ser Val Pro Gly Ser Cys Lys Glu Thr Phe Asn 
            100                 105                 110         


Leu Tyr Tyr Tyr Glu Ala Asp Phe Asp Ser Ala Thr Lys Thr Phe Pro 
        115                 120                 125             


Asn Trp Met Glu Asn Pro Trp Val Lys Val Asp Thr Ile Ala Ala Asp 
    130                 135                 140                 


Glu Ser Phe Ser Gln Val Asp Leu Gly Gly Arg Val Met Lys Ile Asn 
145                 150                 155                 160 


Thr Glu Val Arg Ser Phe Gly Pro Val Ser Arg Ser Gly Phe Tyr Leu 
                165                 170                 175     


Ala Phe Gln Asp Tyr Gly Gly Cys Met Ser Leu Ile Ala Val Arg Val 
            180                 185                 190         


Phe Tyr Arg Lys Cys Pro Arg Ile Ile Gln Asn Gly Ala Ile Phe Gln 
        195                 200                 205             


Glu Thr Leu Ser Gly Ala Glu Ser Thr Ser Leu Val Ala Ala Arg Gly 
    210                 215                 220                 


Ser Cys Ile Ala Asn Ala Glu Glu Val Asp Val Pro Ile Lys Leu Tyr 
225                 230                 235                 240 


Cys Asn Gly Asp Gly Glu Trp Leu Val Pro Ile Gly Arg Cys Met Cys 
                245                 250                 255     


Lys Ala Gly Phe Glu Ala Val Glu Asn Gly Thr Val Cys Arg Gly Cys 
            260                 265                 270         


Pro Ser Gly Thr Phe Lys Ala Asn Gln Gly Asp Glu Ala Cys Thr His 
        275                 280                 285             


Cys Pro Ile Asn Ser Arg Thr Thr Ser Glu Gly Ala Thr Asn Cys Val 
    290                 295                 300                 


Cys Arg Asn Gly Tyr Tyr Arg Ala Asp Leu Asp Pro Leu Asp Met Pro 
305                 310                 315                 320 


Cys Thr Thr Ile Pro Ser Ala Pro Gln Ala Val Ile Ser Ser Val Asn 
                325                 330                 335     


Glu Thr Ser Leu Met Leu Glu Trp Thr Pro Pro Arg Asp Ser Gly Gly 
            340                 345                 350         


Arg Glu Asp Leu Val Tyr Asn Ile Ile Cys Lys Ser Cys Gly Ser Gly 
        355                 360                 365             


Arg Gly Ala Cys Thr Arg Cys Gly Asp Asn Val Gln Tyr Ala Pro Arg 
    370                 375                 380                 


Gln Leu Gly Leu Thr Glu Pro Arg Ile Tyr Ile Ser Asp Leu Leu Ala 
385                 390                 395                 400 


His Thr Gln Tyr Thr Phe Glu Ile Gln Ala Val Asn Gly Val Thr Asp 
                405                 410                 415     


Gln Ser Pro Phe Ser Pro Gln Phe Ala Ser Val Asn Ile Thr Thr Asn 
            420                 425                 430         


Gln Ala Ala Pro Ser Ala Val Ser Ile Met His Gln Val Ser Arg Thr 
        435                 440                 445             


Val Asp Ser Ile Thr Leu Ser Trp Ser Gln Pro Asp Gln Pro Asn Gly 
    450                 455                 460                 


Val Ile Leu Asp Tyr Glu Leu Gln Tyr Tyr Glu Lys Met Lys Thr Gln 
465                 470                 475                 480 


Arg Ser 
        


<210>  4827
<211>  946
<212>  PRT
<213>  Homo Sapiens

<400>  4827

Met Trp Val Pro Val Leu Ala Leu Pro Val Cys Thr Tyr Ala Glu Thr 
1               5                   10                  15      


Leu Met Asp Ser Thr Thr Ala Thr Ala Glu Leu Gly Trp Met Val His 
            20                  25                  30          


Pro Pro Ser Gly Trp Glu Glu Val Ser Gly Tyr Asp Glu Asn Met Asn 
        35                  40                  45              


Thr Ile Arg Thr Tyr Gln Val Cys Asn Val Phe Glu Ser Ser Gln Asn 
    50                  55                  60                  


Asn Trp Leu Arg Thr Lys Phe Ile Arg Arg Arg Gly Ala His Arg Ile 
65                  70                  75                  80  


His Val Glu Met Lys Phe Ser Val Arg Asp Cys Ser Ser Ile Pro Ser 
                85                  90                  95      


Val Pro Gly Ser Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Tyr Glu Ala 
            100                 105                 110         


Asp Phe Asp Ser Ala Thr Lys Thr Phe Pro Asn Trp Met Glu Asn Pro 
        115                 120                 125             


Trp Val Lys Val Asp Thr Ile Ala Ala Asp Glu Ser Phe Ser Gln Val 
    130                 135                 140                 


Asp Leu Gly Gly Arg Val Met Lys Ile Asn Thr Glu Val Arg Ser Phe 
145                 150                 155                 160 


Gly Pro Val Ser Arg Ser Gly Phe Tyr Leu Ala Phe Gln Asp Tyr Gly 
                165                 170                 175     


Gly Cys Met Ser Leu Ile Ala Val Arg Val Phe Tyr Arg Lys Cys Pro 
            180                 185                 190         


Arg Ile Ile Gln Asn Gly Ala Ile Phe Gln Glu Thr Leu Ser Gly Ala 
        195                 200                 205             


Glu Ser Thr Ser Leu Val Ala Ala Arg Gly Ser Cys Ile Ala Asn Ala 
    210                 215                 220                 


Glu Glu Val Asp Val Pro Ile Lys Leu Tyr Cys Asn Gly Asp Gly Glu 
225                 230                 235                 240 


Trp Leu Val Pro Ile Gly Arg Cys Met Cys Lys Ala Gly Phe Glu Ala 
                245                 250                 255     


Val Glu Asn Gly Thr Val Cys Arg Gly Cys Pro Ser Gly Thr Phe Lys 
            260                 265                 270         


Ala Asn Gln Gly Asp Glu Ala Cys Thr His Cys Pro Ile Asn Ser Arg 
        275                 280                 285             


Thr Thr Ser Glu Gly Ala Thr Asn Cys Val Cys Arg Asn Gly Tyr Tyr 
    290                 295                 300                 


Arg Ala Asp Leu Asp Pro Leu Asp Met Pro Cys Thr Thr Ile Pro Ser 
305                 310                 315                 320 


Ala Pro Gln Ala Val Ile Ser Ser Val Asn Glu Thr Ser Leu Met Leu 
                325                 330                 335     


Glu Trp Thr Pro Pro Arg Asp Ser Gly Gly Arg Glu Asp Leu Val Tyr 
            340                 345                 350         


Asn Ile Ile Cys Lys Ser Cys Gly Ser Gly Arg Gly Ala Cys Thr Arg 
        355                 360                 365             


Cys Gly Asp Asn Val Gln Tyr Ala Pro Arg Gln Leu Gly Leu Thr Glu 
    370                 375                 380                 


Pro Arg Ile Tyr Ile Ser Asp Leu Leu Ala His Thr Gln Tyr Thr Phe 
385                 390                 395                 400 


Glu Ile Gln Ala Val Asn Gly Val Thr Asp Gln Ser Pro Phe Ser Pro 
                405                 410                 415     


Gln Phe Ala Ser Val Asn Ile Thr Thr Asn Gln Ala Ala Pro Ser Ala 
            420                 425                 430         


Val Ser Ile Met His Gln Val Ser Arg Thr Val Asp Ser Ile Thr Leu 
        435                 440                 445             


Ser Trp Ser Gln Pro Asp Gln Pro Asn Gly Val Ile Leu Asp Tyr Glu 
    450                 455                 460                 


Leu Gln Tyr Tyr Glu Lys Gln Glu Leu Ser Glu Tyr Asn Ala Thr Ala 
465                 470                 475                 480 


Ile Lys Ser Pro Thr Asn Thr Val Thr Val Gln Gly Leu Lys Ala Gly 
                485                 490                 495     


Ala Ile Tyr Val Phe Gln Val Arg Ala Arg Thr Val Ala Gly Tyr Gly 
            500                 505                 510         


Arg Tyr Ser Gly Lys Met Tyr Phe Gln Thr Met Thr Glu Ala Glu Tyr 
        515                 520                 525             


Gln Thr Ser Ile Gln Glu Lys Leu Pro Leu Ile Ile Gly Ser Ser Ala 
    530                 535                 540                 


Ala Gly Leu Val Phe Leu Ile Ala Val Val Val Ile Ala Ile Val Cys 
545                 550                 555                 560 


Asn Arg Arg Gly Phe Glu Arg Ala Asp Ser Glu Tyr Thr Asp Lys Leu 
                565                 570                 575     


Gln His Tyr Thr Ser Gly His Met Thr Pro Gly Met Lys Ile Tyr Ile 
            580                 585                 590         


Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala Val Arg Glu Phe Ala 
        595                 600                 605             


Lys Glu Ile Asp Ile Ser Cys Val Lys Ile Glu Gln Val Ile Gly Ala 
    610                 615                 620                 


Gly Glu Phe Gly Glu Val Cys Ser Gly His Leu Lys Leu Pro Gly Lys 
625                 630                 635                 640 


Arg Glu Ile Phe Val Ala Ile Lys Thr Leu Lys Ser Gly Tyr Thr Glu 
                645                 650                 655     


Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser Ile Met Gly Gln Phe 
            660                 665                 670         


Asp His Pro Asn Val Ile His Leu Glu Gly Val Val Thr Lys Ser Thr 
        675                 680                 685             


Pro Val Met Ile Ile Thr Glu Phe Met Glu Asn Gly Ser Leu Asp Ser 
    690                 695                 700                 


Phe Leu Arg Gln Asn Asp Gly Gln Phe Thr Val Ile Gln Leu Val Gly 
705                 710                 715                 720 


Met Leu Arg Gly Ile Ala Ala Gly Met Lys Tyr Leu Ala Asp Met Asn 
                725                 730                 735     


Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser Asn 
            740                 745                 750         


Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Phe Leu Glu Asp 
        755                 760                 765             


Asp Thr Ser Asp Pro Thr Tyr Thr Ser Ala Leu Gly Gly Lys Ile Pro 
    770                 775                 780                 


Ile Arg Trp Thr Ala Pro Glu Ala Ile Gln Tyr Arg Lys Phe Thr Ser 
785                 790                 795                 800 


Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu Val Met Ser 
                805                 810                 815     


Tyr Gly Glu Arg Pro Tyr Trp Asp Met Thr Asn Gln Asp Val Ile Asn 
            820                 825                 830         


Ala Ile Glu Gln Asp Tyr Arg Leu Pro Pro Pro Met Asp Cys Pro Ser 
        835                 840                 845             


Ala Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Asp Arg Asn His 
    850                 855                 860                 


Arg Pro Lys Phe Gly Gln Ile Val Asn Thr Leu Asp Lys Met Ile Arg 
865                 870                 875                 880 


Asn Pro Asn Ser Leu Lys Ala Met Ala Pro Leu Ser Ser Gly Ile Asn 
                885                 890                 895     


Leu Pro Leu Leu Asp Arg Thr Ile Pro Asp Tyr Thr Ser Phe Asn Thr 
            900                 905                 910         


Val Asp Glu Trp Leu Glu Ala Ile Lys Met Gly Gln Tyr Lys Glu Ser 
        915                 920                 925             


Phe Ala Asn Ala Gly Phe Thr Ser Phe Asp Val Val Ser Gln Met Met 
    930                 935                 940                 


Met Glu 
945     


<210>  4828
<211>  935
<212>  PRT
<213>  Homo Sapiens

<400>  4828

Met Glu Leu Arg Val Leu Leu Cys Trp Ala Ser Leu Ala Ala Ala Leu 
1               5                   10                  15      


Glu Glu Thr Leu Leu Asn Thr Lys Leu Glu Thr Ala Asp Leu Lys Trp 
            20                  25                  30          


Val Thr Phe Pro Gln Val Asp Gly Gln Trp Glu Glu Leu Ser Gly Leu 
        35                  40                  45              


Asp Glu Glu Gln His Ser Val Arg Thr Tyr Glu Val Cys Asp Val Gln 
    50                  55                  60                  


Arg Ala Pro Gly Gln Ala His Trp Leu Arg Thr Gly Trp Val Pro Arg 
65                  70                  75                  80  


Arg Gly Ala Val His Val Tyr Ala Thr Leu Arg Phe Thr Met Leu Glu 
                85                  90                  95      


Cys Leu Ser Leu Pro Arg Ala Gly Arg Ser Cys Lys Glu Thr Phe Thr 
            100                 105                 110         


Val Phe Tyr Tyr Glu Ser Asp Ala Asp Thr Ala Thr Ala Leu Thr Pro 
        115                 120                 125             


Ala Trp Met Glu Asn Pro Tyr Ile Lys Val Asp Thr Val Ala Ala Glu 
    130                 135                 140                 


His Leu Thr Arg Lys Arg Pro Gly Ala Glu Ala Thr Gly Lys Val Asn 
145                 150                 155                 160 


Val Lys Thr Leu Arg Leu Gly Pro Leu Ser Lys Ala Gly Phe Tyr Leu 
                165                 170                 175     


Ala Phe Gln Asp Gln Gly Ala Cys Met Ala Leu Leu Ser Leu His Leu 
            180                 185                 190         


Phe Tyr Lys Lys Cys Ala Gln Leu Thr Val Asn Leu Thr Arg Phe Pro 
        195                 200                 205             


Glu Thr Val Pro Arg Glu Leu Val Val Pro Val Ala Gly Ser Cys Val 
    210                 215                 220                 


Val Asp Ala Val Pro Ala Pro Gly Pro Ser Pro Ser Leu Tyr Cys Arg 
225                 230                 235                 240 


Glu Asp Gly Gln Trp Ala Glu Gln Pro Val Thr Gly Cys Ser Cys Ala 
                245                 250                 255     


Pro Gly Phe Glu Ala Ala Glu Gly Asn Thr Lys Cys Arg Ala Cys Ala 
            260                 265                 270         


Gln Gly Thr Phe Lys Pro Leu Ser Gly Glu Gly Ser Cys Gln Pro Cys 
        275                 280                 285             


Pro Ala Asn Ser His Ser Asn Thr Ile Gly Ser Ala Val Cys Gln Cys 
    290                 295                 300                 


Arg Val Gly Tyr Phe Arg Ala Arg Thr Asp Pro Arg Gly Ala Pro Cys 
305                 310                 315                 320 


Thr Thr Pro Pro Ser Ala Pro Arg Ser Val Val Ser Arg Leu Asn Gly 
                325                 330                 335     


Ser Ser Leu His Leu Glu Trp Ser Ala Pro Leu Glu Ser Gly Gly Arg 
            340                 345                 350         


Glu Asp Leu Thr Tyr Ala Leu Arg Cys Arg Glu Cys Arg Pro Gly Gly 
        355                 360                 365             


Ser Cys Ala Pro Cys Gly Gly Asp Leu Thr Phe Asp Pro Gly Pro Arg 
    370                 375                 380                 


Asp Leu Val Glu Pro Trp Val Val Val Arg Gly Leu Arg Pro Asp Phe 
385                 390                 395                 400 


Thr Tyr Thr Phe Glu Val Thr Ala Leu Asn Gly Val Ser Ser Leu Ala 
                405                 410                 415     


Thr Gly Pro Val Pro Phe Glu Pro Val Asn Val Thr Thr Asp Arg Glu 
            420                 425                 430         


Val Pro Pro Ala Val Ser Asp Ile Arg Val Thr Arg Ser Ser Pro Ser 
        435                 440                 445             


Ser Leu Ser Leu Ala Trp Ala Val Pro Arg Ala Pro Ser Gly Ala Val 
    450                 455                 460                 


Leu Asp Tyr Glu Val Lys Tyr His Glu Lys Gly Ala Glu Gly Pro Ser 
465                 470                 475                 480 


Ser Val Arg Phe Leu Lys Thr Ser Glu Asn Arg Ala Glu Leu Arg Gly 
                485                 490                 495     


Leu Lys Arg Gly Ala Ser Tyr Leu Val Gln Val Arg Ala Arg Ser Glu 
            500                 505                 510         


Ala Gly Tyr Gly Pro Phe Gly Gln Glu His His Ser Gln Thr Gln Leu 
        515                 520                 525             


Asp Glu Ser Glu Gly Trp Arg Glu Gln Leu Ala Leu Ile Ala Gly Thr 
    530                 535                 540                 


Ala Val Val Gly Val Val Leu Val Leu Val Val Ile Val Val Ala Val 
545                 550                 555                 560 


Leu Cys Leu Arg Lys Gln Ser Asn Gly Arg Glu Ala Glu Tyr Ser Asp 
                565                 570                 575     


Lys His Gly Gln Tyr Leu Ile Gly His Gly Thr Lys Val Tyr Ile Asp 
            580                 585                 590         


Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala Val Arg Glu Phe Ala Lys 
        595                 600                 605             


Glu Ile Asp Val Ser Tyr Val Lys Ile Glu Glu Val Ile Gly Ala Gly 
    610                 615                 620                 


Glu Phe Gly Glu Val Cys Arg Gly Arg Leu Lys Ala Pro Gly Lys Lys 
625                 630                 635                 640 


Glu Ser Cys Val Ala Ile Lys Thr Leu Lys Gly Gly Tyr Thr Glu Arg 
                645                 650                 655     


Gln Arg Arg Glu Phe Leu Ser Glu Ala Ser Ile Met Gly Gln Phe Glu 
            660                 665                 670         


His Pro Asn Ile Ile Arg Leu Glu Gly Val Val Thr Asn Ser Met Pro 
        675                 680                 685             


Val Met Ile Leu Thr Glu Phe Met Glu Asn Gly Ala Leu Asp Ser Phe 
    690                 695                 700                 


Leu Arg Leu Asn Asp Gly Gln Phe Thr Val Ile Gln Leu Val Gly Met 
705                 710                 715                 720 


Leu Arg Gly Ile Ala Ser Gly Met Arg Tyr Leu Ala Glu Met Ser Tyr 
                725                 730                 735     


Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser Asn Leu 
            740                 745                 750         


Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Phe Leu Glu Glu Asn 
        755                 760                 765             


Ser Ser Asp Pro Thr Tyr Thr Ser Ser Leu Gly Gly Lys Ile Pro Ile 
    770                 775                 780                 


Arg Trp Thr Ala Pro Glu Ala Ile Ala Phe Arg Lys Phe Thr Ser Ala 
785                 790                 795                 800 


Ser Asp Ala Trp Ser Tyr Gly Ile Val Met Trp Glu Val Met Ser Phe 
                805                 810                 815     


Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp Val Ile Asn Ala 
            820                 825                 830         


Ile Glu Gln Asp Tyr Arg Leu Pro Pro Pro Pro Asp Cys Pro Thr Ser 
        835                 840                 845             


Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Asp Arg Asn Ala Arg 
    850                 855                 860                 


Pro Arg Phe Pro Gln Val Val Ser Ala Leu Asp Lys Met Ile Arg Asn 
865                 870                 875                 880 


Pro Ala Ser Leu Lys Ile Val Ala Arg Glu Asn Gly Gly Asp Leu Leu 
                885                 890                 895     


Arg Ile Gly Val Thr Leu Ala Gly His Gln Lys Lys Ile Leu Ala Ser 
            900                 905                 910         


Val Gln His Met Lys Ser Gln Ala Lys Pro Gly Thr Pro Gly Gly Thr 
        915                 920                 925             


Gly Gly Pro Ala Pro Gln Tyr 
    930                 935 


<210>  4829
<211>  987
<212>  PRT
<213>  Homo Sapiens

<400>  4829

Met Glu Leu Arg Val Leu Leu Cys Trp Ala Ser Leu Ala Ala Ala Leu 
1               5                   10                  15      


Glu Glu Thr Leu Leu Asn Thr Lys Leu Glu Thr Ala Asp Leu Lys Trp 
            20                  25                  30          


Val Thr Phe Pro Gln Val Asp Gly Gln Trp Glu Glu Leu Ser Gly Leu 
        35                  40                  45              


Asp Glu Glu Gln His Ser Val Arg Thr Tyr Glu Val Cys Asp Val Gln 
    50                  55                  60                  


Arg Ala Pro Gly Gln Ala His Trp Leu Arg Thr Gly Trp Val Pro Arg 
65                  70                  75                  80  


Arg Gly Ala Val His Val Tyr Ala Thr Leu Arg Phe Thr Met Leu Glu 
                85                  90                  95      


Cys Leu Ser Leu Pro Arg Ala Gly Arg Ser Cys Lys Glu Thr Phe Thr 
            100                 105                 110         


Val Phe Tyr Tyr Glu Ser Asp Ala Asp Thr Ala Thr Ala Leu Thr Pro 
        115                 120                 125             


Ala Trp Met Glu Asn Pro Tyr Ile Lys Val Asp Thr Val Ala Ala Glu 
    130                 135                 140                 


His Leu Thr Arg Lys Arg Pro Gly Ala Glu Ala Thr Gly Lys Val Asn 
145                 150                 155                 160 


Val Lys Thr Leu Arg Leu Gly Pro Leu Ser Lys Ala Gly Phe Tyr Leu 
                165                 170                 175     


Ala Phe Gln Asp Gln Gly Ala Cys Met Ala Leu Leu Ser Leu His Leu 
            180                 185                 190         


Phe Tyr Lys Lys Cys Ala Gln Leu Thr Val Asn Leu Thr Arg Phe Pro 
        195                 200                 205             


Glu Thr Val Pro Arg Glu Leu Val Val Pro Val Ala Gly Ser Cys Val 
    210                 215                 220                 


Val Asp Ala Val Pro Ala Pro Gly Pro Ser Pro Ser Leu Tyr Cys Arg 
225                 230                 235                 240 


Glu Asp Gly Gln Trp Ala Glu Gln Pro Val Thr Gly Cys Ser Cys Ala 
                245                 250                 255     


Pro Gly Phe Glu Ala Ala Glu Gly Asn Thr Lys Cys Arg Ala Cys Ala 
            260                 265                 270         


Gln Gly Thr Phe Lys Pro Leu Ser Gly Glu Gly Ser Cys Gln Pro Cys 
        275                 280                 285             


Pro Ala Asn Ser His Ser Asn Thr Ile Gly Ser Ala Val Cys Gln Cys 
    290                 295                 300                 


Arg Val Gly Tyr Phe Arg Ala Arg Thr Asp Pro Arg Gly Ala Pro Cys 
305                 310                 315                 320 


Thr Thr Pro Pro Ser Ala Pro Arg Ser Val Val Ser Arg Leu Asn Gly 
                325                 330                 335     


Ser Ser Leu His Leu Glu Trp Ser Ala Pro Leu Glu Ser Gly Gly Arg 
            340                 345                 350         


Glu Asp Leu Thr Tyr Ala Leu Arg Cys Arg Glu Cys Arg Pro Gly Gly 
        355                 360                 365             


Ser Cys Ala Pro Cys Gly Gly Asp Leu Thr Phe Asp Pro Gly Pro Arg 
    370                 375                 380                 


Asp Leu Val Glu Pro Trp Val Val Val Arg Gly Leu Arg Pro Asp Phe 
385                 390                 395                 400 


Thr Tyr Thr Phe Glu Val Thr Ala Leu Asn Gly Val Ser Ser Leu Ala 
                405                 410                 415     


Thr Gly Pro Val Pro Phe Glu Pro Val Asn Val Thr Thr Asp Arg Glu 
            420                 425                 430         


Val Pro Pro Ala Val Ser Asp Ile Arg Val Thr Arg Ser Ser Pro Ser 
        435                 440                 445             


Ser Leu Ser Leu Ala Trp Ala Val Pro Arg Ala Pro Ser Gly Ala Val 
    450                 455                 460                 


Leu Asp Tyr Glu Val Lys Tyr His Glu Lys Gly Ala Glu Gly Pro Ser 
465                 470                 475                 480 


Ser Val Arg Phe Leu Lys Thr Ser Glu Asn Arg Ala Glu Leu Arg Gly 
                485                 490                 495     


Leu Lys Arg Gly Ala Ser Tyr Leu Val Gln Val Arg Ala Arg Ser Glu 
            500                 505                 510         


Ala Gly Tyr Gly Pro Phe Gly Gln Glu His His Ser Gln Thr Gln Leu 
        515                 520                 525             


Asp Glu Ser Glu Gly Trp Arg Glu Gln Leu Ala Leu Ile Ala Gly Thr 
    530                 535                 540                 


Ala Val Val Gly Val Val Leu Val Leu Val Val Ile Val Val Ala Val 
545                 550                 555                 560 


Leu Cys Leu Arg Lys Gln Ser Asn Gly Arg Glu Ala Glu Tyr Ser Asp 
                565                 570                 575     


Lys His Gly Gln Tyr Leu Ile Gly His Gly Thr Lys Val Tyr Ile Asp 
            580                 585                 590         


Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala Val Arg Glu Phe Ala Lys 
        595                 600                 605             


Glu Ile Asp Val Ser Tyr Val Lys Ile Glu Glu Val Ile Gly Ala Gly 
    610                 615                 620                 


Glu Phe Gly Glu Val Cys Arg Gly Arg Leu Lys Ala Pro Gly Lys Lys 
625                 630                 635                 640 


Glu Ser Cys Val Ala Ile Lys Thr Leu Lys Gly Gly Tyr Thr Glu Arg 
                645                 650                 655     


Gln Arg Arg Glu Phe Leu Ser Glu Ala Ser Ile Met Gly Gln Phe Glu 
            660                 665                 670         


His Pro Asn Ile Ile Arg Leu Glu Gly Val Val Thr Asn Ser Met Pro 
        675                 680                 685             


Val Met Ile Leu Thr Glu Phe Met Glu Asn Gly Ala Leu Asp Ser Phe 
    690                 695                 700                 


Leu Arg Leu Asn Asp Gly Gln Phe Thr Val Ile Gln Leu Val Gly Met 
705                 710                 715                 720 


Leu Arg Gly Ile Ala Ser Gly Met Arg Tyr Leu Ala Glu Met Ser Tyr 
                725                 730                 735     


Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser Asn Leu 
            740                 745                 750         


Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Phe Leu Glu Glu Asn 
        755                 760                 765             


Ser Ser Asp Pro Thr Tyr Thr Ser Ser Leu Gly Gly Lys Ile Pro Ile 
    770                 775                 780                 


Arg Trp Thr Ala Pro Glu Ala Ile Ala Phe Arg Lys Phe Thr Ser Ala 
785                 790                 795                 800 


Ser Asp Ala Trp Ser Tyr Gly Ile Val Met Trp Glu Val Met Ser Phe 
                805                 810                 815     


Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp Val Ile Asn Ala 
            820                 825                 830         


Ile Glu Gln Asp Tyr Arg Leu Pro Pro Pro Pro Asp Cys Pro Thr Ser 
        835                 840                 845             


Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Asp Arg Asn Ala Arg 
    850                 855                 860                 


Pro Arg Phe Pro Gln Val Val Ser Ala Leu Asp Lys Met Ile Arg Asn 
865                 870                 875                 880 


Pro Ala Ser Leu Lys Ile Val Ala Arg Glu Asn Gly Gly Ala Ser His 
                885                 890                 895     


Pro Leu Leu Asp Gln Arg Gln Pro His Tyr Ser Ala Phe Gly Ser Val 
            900                 905                 910         


Gly Glu Trp Leu Arg Ala Ile Lys Met Gly Arg Tyr Glu Glu Ser Phe 
        915                 920                 925             


Ala Ala Ala Gly Phe Gly Ser Phe Glu Leu Val Ser Gln Ile Ser Ala 
    930                 935                 940                 


Glu Asp Leu Leu Arg Ile Gly Val Thr Leu Ala Gly His Gln Lys Lys 
945                 950                 955                 960 


Ile Leu Ala Ser Val Gln His Met Lys Ser Gln Ala Lys Pro Gly Thr 
                965                 970                 975     


Pro Gly Gly Thr Gly Gly Pro Ala Pro Gln Tyr 
            980                 985         


<210>  4830
<211>  306
<212>  PRT
<213>  Homo Sapiens

<400>  4830

Met Glu Leu Arg Val Leu Leu Cys Trp Ala Ser Leu Ala Ala Ala Leu 
1               5                   10                  15      


Glu Glu Thr Leu Leu Asn Thr Lys Leu Glu Thr Ala Asp Leu Lys Trp 
            20                  25                  30          


Val Thr Phe Pro Gln Val Asp Gly Gln Trp Glu Glu Leu Ser Gly Leu 
        35                  40                  45              


Asp Glu Glu Gln His Ser Val Arg Thr Tyr Glu Val Cys Asp Val Gln 
    50                  55                  60                  


Arg Ala Pro Gly Gln Ala His Trp Leu Arg Thr Gly Trp Val Pro Arg 
65                  70                  75                  80  


Arg Gly Ala Val His Val Tyr Ala Thr Leu Arg Phe Thr Met Leu Glu 
                85                  90                  95      


Cys Leu Ser Leu Pro Arg Ala Gly Arg Ser Cys Lys Glu Thr Phe Thr 
            100                 105                 110         


Val Phe Tyr Tyr Glu Ser Asp Ala Asp Thr Ala Thr Ala Leu Thr Pro 
        115                 120                 125             


Ala Trp Met Glu Asn Pro Tyr Ile Lys Val Asp Thr Val Ala Ala Glu 
    130                 135                 140                 


His Leu Thr Arg Lys Arg Pro Gly Ala Glu Ala Thr Gly Lys Val Asn 
145                 150                 155                 160 


Val Lys Thr Leu Arg Leu Gly Pro Leu Ser Lys Ala Gly Phe Tyr Leu 
                165                 170                 175     


Ala Phe Gln Asp Gln Gly Ala Cys Met Ala Leu Leu Ser Leu His Leu 
            180                 185                 190         


Phe Tyr Lys Lys Cys Ala Gln Leu Thr Val Asn Leu Thr Arg Phe Pro 
        195                 200                 205             


Glu Thr Val Pro Arg Glu Leu Val Val Pro Val Ala Gly Ser Cys Val 
    210                 215                 220                 


Val Asp Ala Val Pro Ala Pro Gly Pro Ser Pro Ser Leu Tyr Cys Arg 
225                 230                 235                 240 


Glu Asp Gly Gln Trp Ala Glu Gln Pro Val Thr Gly Cys Ser Cys Ala 
                245                 250                 255     


Pro Gly Phe Glu Ala Ala Glu Gly Asn Thr Lys Cys Arg Gly Arg Arg 
            260                 265                 270         


Gly Ser Gln Gln Arg Ala Val Pro Glu Asp Val Arg Lys Pro Gly Arg 
        275                 280                 285             


Ala Ala Gly Ala Glu Ala Gly Ser Gln Leu Pro Gly Ala Gly Thr Gly 
    290                 295                 300                 


Ala Leu 
305     


<210>  4831
<211>  126
<212>  PRT
<213>  Homo Sapiens

<400>  4831

Met Pro Glu Leu Val Val Thr Ala Leu Leu Ala Pro Ser Arg Leu Ser 
1               5                   10                  15      


Leu Lys Leu Leu Arg Ala Phe Met Trp Ser Leu Val Phe Ser Val Ala 
            20                  25                  30          


Leu Val Ala Ala Ala Val Tyr Gly Cys Ile Ala Leu Thr His Val Leu 
        35                  40                  45              


Cys Arg Pro Arg Arg Gly Cys Cys Gly Arg Arg Arg Ser Ala Ser Pro 
    50                  55                  60                  


Ala Cys Leu Ser Asp Pro Ser Leu Gly Glu His Gly Phe Leu Asn Leu 
65                  70                  75                  80  


Lys Ser Ser Gly Leu Arg Leu His Tyr Val Ser Ala Gly Arg Gly Asn 
                85                  90                  95      


Gly Pro Leu Met Leu Phe Leu His Gly Phe Pro Glu Asn Trp Phe Ser 
            100                 105                 110         


Trp Arg Tyr Gln Leu Arg Glu Phe Gln Ser Arg Phe His Val 
        115                 120                 125     


<210>  4832
<211>  360
<212>  PRT
<213>  Homo Sapiens

<400>  4832

Met Pro Glu Leu Val Val Thr Ala Leu Leu Ala Pro Ser Arg Leu Ser 
1               5                   10                  15      


Leu Lys Leu Leu Arg Ala Phe Met Trp Ser Leu Val Phe Ser Val Ala 
            20                  25                  30          


Leu Val Ala Ala Ala Val Tyr Gly Cys Ile Ala Leu Thr His Val Leu 
        35                  40                  45              


Cys Arg Pro Arg Arg Gly Cys Cys Gly Arg Arg Arg Ser Ala Ser Pro 
    50                  55                  60                  


Ala Cys Leu Ser Asp Pro Ser Leu Gly Glu His Gly Phe Leu Asn Leu 
65                  70                  75                  80  


Lys Ser Ser Gly Leu Arg Leu His Tyr Val Ser Ala Gly Arg Gly Asn 
                85                  90                  95      


Gly Pro Leu Met Leu Phe Leu His Gly Phe Pro Glu Asn Trp Phe Ser 
            100                 105                 110         


Trp Arg Tyr Gln Leu Arg Glu Phe Gln Ser Arg Phe His Val Val Ala 
        115                 120                 125             


Val Asp Leu Arg Gly Tyr Gly Pro Ser Asp Ala Pro Arg Asp Val Asp 
    130                 135                 140                 


Cys Tyr Thr Ile Asp Leu Leu Leu Val Asp Ile Lys Asp Val Ile Leu 
145                 150                 155                 160 


Gly Leu Gly Tyr Ser Lys Cys Ile Leu Val Ala His Asp Trp Gly Ala 
                165                 170                 175     


Leu Leu Ala Trp His Phe Ser Ile Tyr Tyr Pro Ser Leu Val Glu Arg 
            180                 185                 190         


Met Val Val Val Ser Gly Ala Pro Met Ser Val Tyr Gln Asp Tyr Ser 
        195                 200                 205             


Leu His His Ile Ser Gln Phe Phe Arg Ser His Tyr Met Phe Leu Phe 
    210                 215                 220                 


Gln Leu Pro Trp Leu Pro Glu Lys Leu Leu Ser Met Ser Asp Phe Gln 
225                 230                 235                 240 


Ile Leu Lys Thr Thr Leu Thr His Arg Lys Thr Gly Ile Pro Cys Leu 
                245                 250                 255     


Thr Pro Ser Glu Leu Glu Ala Phe Leu Tyr Asn Phe Ser Gln Pro Gly 
            260                 265                 270         


Gly Leu Thr Gly Pro Leu Asn Tyr Tyr Arg Asn Leu Phe Arg Asn Phe 
        275                 280                 285             


Pro Leu Glu Pro Gln Glu Leu Thr Thr Pro Thr Leu Leu Leu Trp Gly 
    290                 295                 300                 


Glu Lys Asp Thr Tyr Leu Glu Leu Gly Leu Val Glu Ala Ile Gly Ser 
305                 310                 315                 320 


Arg Phe Val Pro Gly Arg Leu Glu Ala His Ile Leu Pro Gly Ile Gly 
                325                 330                 335     


His Trp Ile Pro Gln Ser Asn Pro Gln Glu Met His Gln Tyr Met Trp 
            340                 345                 350         


Ala Phe Leu Gln Asp Leu Leu Asp 
        355                 360 


<210>  4833
<211>  360
<212>  PRT
<213>  Homo Sapiens

<400>  4833

Met Pro Glu Leu Val Val Thr Ala Leu Leu Ala Pro Ser Arg Leu Ser 
1               5                   10                  15      


Leu Lys Leu Leu Arg Ala Phe Met Trp Ser Leu Val Phe Ser Val Ala 
            20                  25                  30          


Leu Val Ala Ala Ala Val Tyr Gly Cys Ile Ala Leu Thr His Val Leu 
        35                  40                  45              


Cys Arg Pro Arg Arg Gly Cys Cys Gly Arg Arg Arg Ser Ala Ser Pro 
    50                  55                  60                  


Ala Cys Leu Ser Asp Pro Ser Leu Gly Glu His Gly Phe Leu Asn Leu 
65                  70                  75                  80  


Lys Ser Ser Gly Leu Arg Leu His Tyr Val Ser Ala Gly Arg Gly Asn 
                85                  90                  95      


Gly Pro Leu Met Leu Phe Leu His Gly Phe Pro Glu Asn Trp Phe Ser 
            100                 105                 110         


Trp Arg Tyr Gln Leu Arg Glu Phe Gln Ser Arg Phe His Val Val Ala 
        115                 120                 125             


Val Asp Leu Arg Gly Tyr Gly Pro Ser Asp Ala Pro Arg Asp Val Asp 
    130                 135                 140                 


Cys Tyr Thr Ile Asp Leu Leu Leu Val Asp Ile Lys Asp Val Ile Leu 
145                 150                 155                 160 


Gly Leu Gly Tyr Ser Lys Cys Ile Leu Val Ala His Asp Trp Gly Ala 
                165                 170                 175     


Leu Leu Ala Trp His Phe Ser Ile Tyr Tyr Pro Ser Leu Val Glu Arg 
            180                 185                 190         


Met Val Val Val Ser Gly Ala Pro Met Ser Val Tyr Gln Asp Tyr Ser 
        195                 200                 205             


Leu His His Ile Ser Gln Phe Phe Arg Ser His Tyr Met Phe Leu Phe 
    210                 215                 220                 


Gln Leu Pro Trp Leu Pro Glu Lys Leu Leu Ser Met Ser Asp Phe Gln 
225                 230                 235                 240 


Ile Leu Lys Thr Thr Leu Thr His Arg Lys Thr Gly Ile Pro Cys Leu 
                245                 250                 255     


Thr Pro Ser Glu Leu Glu Ala Phe Leu Tyr Asn Phe Ser Gln Pro Gly 
            260                 265                 270         


Gly Leu Thr Gly Pro Leu Asn Tyr Tyr Arg Asn Leu Phe Arg Asn Phe 
        275                 280                 285             


Pro Leu Glu Pro Gln Glu Leu Thr Thr Pro Thr Leu Leu Leu Trp Gly 
    290                 295                 300                 


Glu Lys Asp Thr Tyr Leu Glu Leu Gly Leu Val Glu Ala Ile Gly Ser 
305                 310                 315                 320 


Arg Phe Val Pro Gly Arg Leu Glu Ala His Ile Leu Pro Gly Ile Gly 
                325                 330                 335     


His Trp Ile Pro Gln Ser Asn Pro Gln Glu Met His Gln Tyr Met Trp 
            340                 345                 350         


Ala Phe Leu Gln Asp Leu Leu Asp 
        355                 360 


<210>  4834
<211>  360
<212>  PRT
<213>  Homo Sapiens

<400>  4834

Met Pro Glu Leu Val Val Thr Ala Leu Leu Ala Pro Ser Arg Leu Ser 
1               5                   10                  15      


Leu Lys Leu Leu Arg Ala Phe Met Trp Ser Leu Val Phe Ser Val Ala 
            20                  25                  30          


Leu Val Ala Ala Ala Val Tyr Gly Cys Ile Ala Leu Thr His Val Leu 
        35                  40                  45              


Cys Arg Pro Arg Arg Gly Cys Cys Gly Arg Arg Arg Ser Ala Ser Pro 
    50                  55                  60                  


Ala Cys Leu Ser Asp Pro Ser Leu Gly Glu His Gly Phe Leu Asn Leu 
65                  70                  75                  80  


Lys Ser Ser Gly Leu Arg Leu His Tyr Val Ser Ala Gly Arg Gly Asn 
                85                  90                  95      


Gly Pro Leu Met Leu Phe Leu His Gly Phe Pro Glu Asn Trp Phe Ser 
            100                 105                 110         


Trp Arg Tyr Gln Leu Arg Glu Phe Gln Ser Arg Phe His Val Val Ala 
        115                 120                 125             


Val Asp Leu Arg Gly Tyr Gly Pro Ser Asp Ala Pro Arg Asp Val Asp 
    130                 135                 140                 


Cys Tyr Thr Ile Asp Leu Leu Leu Val Asp Ile Lys Asp Val Ile Leu 
145                 150                 155                 160 


Gly Leu Gly Tyr Ser Lys Cys Ile Leu Val Ala His Asp Trp Gly Ala 
                165                 170                 175     


Leu Leu Ala Trp His Phe Ser Ile Tyr Tyr Pro Ser Leu Val Glu Arg 
            180                 185                 190         


Met Val Val Val Ser Gly Ala Pro Met Ser Val Tyr Gln Asp Tyr Ser 
        195                 200                 205             


Leu His His Ile Ser Gln Phe Phe Arg Ser His Tyr Met Phe Leu Phe 
    210                 215                 220                 


Gln Leu Pro Trp Leu Pro Glu Lys Leu Leu Ser Met Ser Asp Phe Gln 
225                 230                 235                 240 


Ile Leu Lys Thr Thr Leu Thr His Arg Lys Thr Gly Ile Pro Cys Leu 
                245                 250                 255     


Thr Pro Ser Glu Leu Glu Ala Phe Leu Tyr Asn Phe Ser Gln Pro Gly 
            260                 265                 270         


Gly Leu Thr Gly Pro Leu Asn Tyr Tyr Arg Asn Leu Phe Arg Asn Phe 
        275                 280                 285             


Pro Leu Glu Pro Gln Glu Leu Thr Thr Pro Thr Leu Leu Leu Trp Gly 
    290                 295                 300                 


Glu Lys Asp Thr Tyr Leu Glu Leu Gly Leu Val Glu Ala Ile Gly Ser 
305                 310                 315                 320 


Arg Phe Val Pro Gly Arg Leu Glu Ala His Ile Leu Pro Gly Ile Gly 
                325                 330                 335     


His Trp Ile Pro Gln Ser Asn Pro Gln Glu Met His Gln Tyr Met Trp 
            340                 345                 350         


Ala Phe Leu Gln Asp Leu Leu Asp 
        355                 360 


<210>  4835
<211>  193
<212>  PRT
<213>  Homo Sapiens

<400>  4835

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu 
            20                  25                  30          


Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu Leu Glu Ala Lys Glu 
        35                  40                  45              


Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His Cys Ser Leu Asn Glu 
    50                  55                  60                  


Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Ala Trp Lys Arg 
65                  70                  75                  80  


Met Glu Val Gly Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu 
                85                  90                  95      


Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu Leu Val Asn Ser Ser 
            100                 105                 110         


Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp Lys Ala Val Ser Gly 
        115                 120                 125             


Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu 
    130                 135                 140                 


Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala Pro Leu Arg Thr Ile 
145                 150                 155                 160 


Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val Tyr Ser Asn Phe Leu 
                165                 170                 175     


Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala Cys Arg Thr Gly Asp 
            180                 185                 190         


Arg 
    


<210>  4836
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  4836

Met Gly Ser Ser Gly Leu Leu Ser Leu Leu Val Leu Phe Val Leu Leu 
1               5                   10                  15      


Ala Asn Val Gln Gly Pro Gly Leu Thr Asp Trp Leu Phe Pro Arg Arg 
            20                  25                  30          


Cys Pro Lys Ile Arg Glu Glu Cys Glu Phe Gln Glu Arg Asp Val Cys 
        35                  40                  45              


Thr Lys Asp Arg Gln Cys Gln Asp Asn Lys Lys Cys Cys Val Phe Ser 
    50                  55                  60                  


Cys Gly Lys Lys Cys Leu Asp Leu Lys Gln Asp Val Cys Glu Met Pro 
65                  70                  75                  80  


Lys Glu Thr Gly Pro Cys Leu Ala Tyr Phe Leu His Trp Trp Tyr Asp 
                85                  90                  95      


Lys Lys Asp Asn Thr Cys Ser Met Phe Val Tyr Gly Gly Cys Gln Gly 
            100                 105                 110         


Asn Asn Asn Asn Phe Gln Ser Lys Ala Asn Cys Leu Asn Thr Cys Lys 
        115                 120                 125             


Asn Lys Arg Phe Pro 
    130             


<210>  4837
<211>  77
<212>  PRT
<213>  Homo Sapiens

<400>  4837

Met Gly Ser Ser Gly Leu Leu Ser Leu Leu Val Leu Phe Val Leu Leu 
1               5                   10                  15      


Ala Asn Val Gln Gly Pro Gly Leu Thr Asp Trp Leu Phe Pro Arg Arg 
            20                  25                  30          


Cys Pro Lys Ile Arg Glu Glu Cys Glu Phe Gln Glu Arg Asp Val Cys 
        35                  40                  45              


Thr Lys Asp Arg Gln Cys Gln Asp Asn Lys Lys Cys Cys Val Phe Ser 
    50                  55                  60                  


Cys Gly Lys Lys Cys Leu Asp Leu Lys Gln Gly Lys Gln 
65                  70                  75          


<210>  4838
<211>  117
<212>  PRT
<213>  Homo Sapiens

<400>  4838

Met Leu Ser Lys Ala His Gly Cys Lys Thr Ala Leu Ser Leu Gly Arg 
1               5                   10                  15      


Cys Pro Lys Ile Arg Glu Glu Cys Glu Phe Gln Glu Arg Asp Val Cys 
            20                  25                  30          


Thr Lys Asp Arg Gln Cys Gln Asp Asn Lys Lys Cys Cys Val Phe Ser 
        35                  40                  45              


Cys Gly Lys Lys Cys Leu Asp Leu Lys Gln Asp Val Cys Glu Met Pro 
    50                  55                  60                  


Lys Glu Thr Gly Pro Cys Leu Ala Tyr Phe Leu His Trp Trp Tyr Asp 
65                  70                  75                  80  


Lys Lys Asp Asn Thr Cys Ser Met Phe Val Tyr Gly Gly Cys Gln Gly 
                85                  90                  95      


Asn Asn Asn Asn Phe Gln Ser Lys Ala Asn Cys Leu Asn Thr Cys Lys 
            100                 105                 110         


Asn Lys Arg Phe Pro 
        115         


<210>  4839
<211>  179
<212>  PRT
<213>  Homo Sapiens

<400>  4839

Met Gly Ser Ser Gly Leu Leu Ser Leu Leu Val Leu Phe Val Leu Leu 
1               5                   10                  15      


Ala Asn Val Gln Gly Pro Gly Leu Thr Asp Trp Leu Phe Pro Arg Arg 
            20                  25                  30          


Cys Pro Lys Ile Arg Glu Glu Cys Glu Phe Gln Glu Arg Asp Val Cys 
        35                  40                  45              


Thr Lys Asp Arg Gln Cys Gln Asp Asn Lys Lys Cys Cys Val Phe Ser 
    50                  55                  60                  


Cys Gly Lys Lys Cys Leu Asp Leu Lys Gln Asp Val Cys Glu Met Pro 
65                  70                  75                  80  


Lys Glu Thr Gly Pro Cys Leu Ala Tyr Phe Leu His Trp Trp Tyr Asp 
                85                  90                  95      


Lys Lys Asp Asn Thr Cys Ser Met Phe Val Tyr Gly Gly Cys Gln Gly 
            100                 105                 110         


Asn Asn Asn Asn Phe Gln Ser Lys Ala Asn Cys Leu Asn Thr Cys Lys 
        115                 120                 125             


Asn Lys Gln Pro Cys Pro Lys Ile Lys Val Glu Cys Glu Val Glu Glu 
    130                 135                 140                 


Ile Asp Gln Cys Thr Lys Pro Arg Asp Cys Pro Glu Asn Met Lys Cys 
145                 150                 155                 160 


Cys Pro Phe Ser Arg Gly Lys Lys Cys Leu Asp Phe Arg Lys Ala Ser 
                165                 170                 175     


Leu Ser Thr 
            


<210>  4840
<211>  762
<212>  PRT
<213>  Homo Sapiens

<400>  4840

Met Ala Ala Ala Ala Gln Leu Ser Leu Thr Gln Leu Ser Ser Gly Asn 
1               5                   10                  15      


Pro Val Tyr Glu Lys Tyr Tyr Arg Gln Val Asp Thr Gly Asn Thr Gly 
            20                  25                  30          


Arg Val Leu Ala Ser Asp Ala Ala Ala Phe Leu Lys Lys Ser Gly Leu 
        35                  40                  45              


Pro Asp Leu Ile Leu Gly Lys Ile Trp Asp Leu Ala Asp Thr Asp Gly 
    50                  55                  60                  


Lys Gly Ile Leu Asn Lys Gln Glu Phe Phe Val Ala Leu Arg Leu Val 
65                  70                  75                  80  


Ala Cys Ala Gln Asn Gly Leu Glu Val Ser Leu Ser Ser Leu Asn Leu 
                85                  90                  95      


Ala Val Pro Pro Pro Arg Phe His Asp Thr Ser Ser Pro Leu Leu Ile 
            100                 105                 110         


Ser Gly Thr Ser Ala Ala Glu Leu Pro Trp Ala Val Lys Pro Glu Asp 
        115                 120                 125             


Lys Ala Lys Tyr Asp Ala Ile Phe Asp Ser Leu Ser Pro Val Asn Gly 
    130                 135                 140                 


Phe Leu Ser Gly Asp Lys Val Lys Pro Val Leu Leu Asn Ser Lys Leu 
145                 150                 155                 160 


Pro Val Asp Ile Leu Gly Arg Val Trp Glu Leu Ser Asp Ile Asp His 
                165                 170                 175     


Asp Gly Met Leu Asp Arg Asp Glu Phe Ala Val Ala Met Phe Leu Val 
            180                 185                 190         


Tyr Cys Ala Leu Glu Lys Glu Pro Val Pro Met Ser Leu Pro Pro Ala 
        195                 200                 205             


Leu Val Pro Pro Ser Lys Arg Lys Thr Trp Val Val Ser Pro Ala Glu 
    210                 215                 220                 


Lys Ala Lys Tyr Asp Glu Ile Phe Leu Lys Thr Asp Lys Asp Met Asp 
225                 230                 235                 240 


Gly Phe Val Ser Gly Leu Glu Val Arg Glu Ile Phe Leu Lys Thr Gly 
                245                 250                 255     


Leu Pro Ser Thr Leu Leu Ala His Ile Trp Ser Leu Cys Asp Thr Lys 
            260                 265                 270         


Asp Cys Gly Lys Leu Ser Lys Asp Gln Phe Ala Leu Ala Phe His Leu 
        275                 280                 285             


Ile Ser Gln Lys Leu Ile Lys Gly Ile Asp Pro Pro His Val Leu Thr 
    290                 295                 300                 


Pro Glu Met Ile Pro Pro Ser Asp Arg Ala Ser Leu Gln Lys Asn Ile 
305                 310                 315                 320 


Ile Gly Ser Ser Pro Val Ala Asp Phe Ser Ala Ile Lys Glu Leu Asp 
                325                 330                 335     


Thr Leu Asn Asn Glu Ile Val Asp Leu Gln Arg Glu Lys Asn Asn Val 
            340                 345                 350         


Glu Gln Asp Leu Lys Glu Lys Glu Asp Thr Ile Lys Gln Arg Thr Ser 
        355                 360                 365             


Glu Val Gln Asp Leu Gln Asp Glu Val Gln Arg Glu Asn Thr Asn Leu 
    370                 375                 380                 


Gln Lys Leu Gln Ala Gln Lys Gln Gln Val Gln Glu Leu Leu Asp Glu 
385                 390                 395                 400 


Leu Asp Glu Gln Lys Ala Gln Leu Glu Glu Gln Leu Lys Glu Val Arg 
                405                 410                 415     


Lys Lys Cys Ala Glu Glu Ala Gln Leu Ala Arg Ser Ser Pro Glu Leu 
            420                 425                 430         


Leu Pro Ser Gly Val Thr Asp Glu Asn Glu Val Thr Thr Ala Val Thr 
        435                 440                 445             


Glu Lys Val Cys Ser Glu Leu Asp Asn Asn Arg His Ser Lys Glu Glu 
    450                 455                 460                 


Asp Pro Phe Asn Val Asp Ser Ser Ser Leu Thr Gly Pro Val Ala Asp 
465                 470                 475                 480 


Thr Asn Leu Asp Phe Phe Gln Ser Asp Pro Phe Val Gly Ser Asp Pro 
                485                 490                 495     


Phe Lys Asp Asp Pro Phe Gly Lys Ile Asp Pro Phe Gly Gly Asp Pro 
            500                 505                 510         


Phe Lys Gly Ser Asp Pro Phe Ala Ser Asp Cys Phe Phe Arg Gln Ser 
        515                 520                 525             


Thr Asp Pro Phe Ala Thr Ser Ser Thr Asp Pro Phe Ser Ala Ala Asn 
    530                 535                 540                 


Asn Ser Ser Ile Thr Ser Val Glu Thr Leu Lys His Asn Asp Pro Phe 
545                 550                 555                 560 


Ala Pro Gly Gly Thr Val Val Ala Ala Ser Asp Ser Ala Thr Asp Pro 
                565                 570                 575     


Phe Ala Ser Val Phe Gly Asn Glu Ser Phe Gly Gly Gly Phe Ala Asp 
            580                 585                 590         


Phe Ser Thr Leu Ser Lys Val Asn Asn Glu Asp Pro Phe Arg Ser Ala 
        595                 600                 605             


Thr Ser Ser Ser Val Ser Asn Val Val Ile Thr Lys Asn Val Phe Glu 
    610                 615                 620                 


Glu Thr Ser Val Lys Ser Glu Asp Glu Pro Pro Ala Leu Pro Pro Lys 
625                 630                 635                 640 


Ile Gly Thr Pro Thr Arg Pro Cys Pro Leu Pro Pro Gly Lys Arg Ser 
                645                 650                 655     


Ile Asn Lys Leu Asp Ser Pro Asp Pro Phe Lys Leu Asn Asp Pro Phe 
            660                 665                 670         


Gln Pro Phe Pro Gly Asn Asp Ser Pro Lys Glu Lys Asp Pro Glu Ile 
        675                 680                 685             


Phe Cys Asp Pro Phe Thr Ser Ala Thr Thr Thr Thr Asn Lys Glu Ala 
    690                 695                 700                 


Asp Pro Ser Asn Phe Ala Asn Phe Ser Ala Tyr Pro Ser Glu Glu Asp 
705                 710                 715                 720 


Met Ile Glu Trp Ala Lys Arg Glu Ser Glu Arg Glu Glu Glu Gln Arg 
                725                 730                 735     


Leu Ala Arg Leu Asn Gln Gln Glu Gln Glu Asp Leu Glu Leu Ala Ile 
            740                 745                 750         


Ala Leu Ser Lys Ser Glu Ile Ser Glu Ala 
        755                 760         


<210>  4841
<211>  896
<212>  PRT
<213>  Homo Sapiens

<400>  4841

Met Ala Ala Ala Ala Gln Leu Ser Leu Thr Gln Leu Ser Ser Gly Asn 
1               5                   10                  15      


Pro Val Tyr Glu Lys Tyr Tyr Arg Gln Val Asp Thr Gly Asn Thr Gly 
            20                  25                  30          


Arg Val Leu Ala Ser Asp Ala Ala Ala Phe Leu Lys Lys Ser Gly Leu 
        35                  40                  45              


Pro Asp Leu Ile Leu Gly Lys Ile Trp Asp Leu Ala Asp Thr Asp Gly 
    50                  55                  60                  


Lys Gly Ile Leu Asn Lys Gln Glu Phe Phe Val Ala Leu Arg Leu Val 
65                  70                  75                  80  


Ala Cys Ala Gln Asn Gly Leu Glu Val Ser Leu Ser Ser Leu Asn Leu 
                85                  90                  95      


Ala Val Pro Pro Pro Arg Phe His Asp Thr Ser Ser Pro Leu Leu Ile 
            100                 105                 110         


Ser Gly Thr Ser Ala Ala Glu Leu Pro Trp Ala Val Lys Pro Glu Asp 
        115                 120                 125             


Lys Ala Lys Tyr Asp Ala Ile Phe Asp Ser Leu Ser Pro Val Asn Gly 
    130                 135                 140                 


Phe Leu Ser Gly Asp Lys Val Lys Pro Val Leu Leu Asn Ser Lys Leu 
145                 150                 155                 160 


Pro Val Asp Ile Leu Gly Arg Val Trp Glu Leu Ser Asp Ile Asp His 
                165                 170                 175     


Asp Gly Met Leu Asp Arg Asp Glu Phe Ala Val Ala Met Phe Leu Val 
            180                 185                 190         


Tyr Cys Ala Leu Glu Lys Glu Pro Val Pro Met Ser Leu Pro Pro Ala 
        195                 200                 205             


Leu Val Pro Pro Ser Lys Arg Lys Thr Trp Val Val Ser Pro Ala Glu 
    210                 215                 220                 


Lys Ala Lys Tyr Asp Glu Ile Phe Leu Lys Thr Asp Lys Asp Met Asp 
225                 230                 235                 240 


Gly Phe Val Ser Gly Leu Glu Val Arg Glu Ile Phe Leu Lys Thr Gly 
                245                 250                 255     


Leu Pro Ser Thr Leu Leu Ala His Ile Trp Ser Leu Cys Asp Thr Lys 
            260                 265                 270         


Asp Cys Gly Lys Leu Ser Lys Asp Gln Phe Ala Leu Ala Phe His Leu 
        275                 280                 285             


Ile Ser Gln Lys Leu Ile Lys Gly Ile Asp Pro Pro His Val Leu Thr 
    290                 295                 300                 


Pro Glu Met Ile Pro Pro Ser Asp Arg Ala Ser Leu Gln Lys Asn Ile 
305                 310                 315                 320 


Ile Gly Ser Ser Pro Val Ala Asp Phe Ser Ala Ile Lys Glu Leu Asp 
                325                 330                 335     


Thr Leu Asn Asn Glu Ile Val Asp Leu Gln Arg Glu Lys Asn Asn Val 
            340                 345                 350         


Glu Gln Asp Leu Lys Glu Lys Glu Asp Thr Ile Lys Gln Arg Thr Ser 
        355                 360                 365             


Glu Val Gln Asp Leu Gln Asp Glu Val Gln Arg Glu Asn Thr Asn Leu 
    370                 375                 380                 


Gln Lys Leu Gln Ala Gln Lys Gln Gln Val Gln Glu Leu Leu Asp Glu 
385                 390                 395                 400 


Leu Asp Glu Gln Lys Ala Gln Leu Glu Glu Gln Leu Lys Glu Val Arg 
                405                 410                 415     


Lys Lys Cys Ala Glu Glu Ala Gln Leu Ile Ser Ser Leu Lys Ala Glu 
            420                 425                 430         


Leu Thr Ser Gln Glu Ser Gln Ile Ser Thr Tyr Glu Glu Glu Leu Ala 
        435                 440                 445             


Lys Ala Arg Glu Glu Leu Ser Arg Leu Gln Gln Glu Thr Ala Glu Leu 
    450                 455                 460                 


Glu Glu Ser Val Glu Ser Gly Lys Ala Gln Leu Glu Pro Leu Gln Gln 
465                 470                 475                 480 


His Leu Gln Asp Ser Gln Gln Glu Ile Ser Ser Met Gln Met Lys Leu 
                485                 490                 495     


Met Glu Met Lys Asp Leu Glu Asn His Asn Ser Gln Leu Asn Trp Cys 
            500                 505                 510         


Ser Ser Pro His Ser Ile Leu Val Asn Gly Ala Thr Asp Tyr Cys Ser 
        515                 520                 525             


Leu Ser Thr Ser Ser Ser Glu Thr Ala Asn Leu Asn Glu His Val Glu 
    530                 535                 540                 


Gly Gln Ser Asn Leu Glu Ser Glu Pro Ile His Gln Glu Ser Pro Ala 
545                 550                 555                 560 


Arg Ser Ser Pro Glu Leu Leu Pro Ser Gly Val Thr Asp Glu Asn Glu 
                565                 570                 575     


Val Thr Thr Ala Val Thr Glu Lys Val Cys Ser Glu Leu Asp Asn Asn 
            580                 585                 590         


Arg His Ser Lys Glu Glu Asp Pro Phe Asn Val Asp Ser Ser Ser Leu 
        595                 600                 605             


Thr Gly Pro Val Ala Asp Thr Asn Leu Asp Phe Phe Gln Ser Asp Pro 
    610                 615                 620                 


Phe Val Gly Ser Asp Pro Phe Lys Asp Asp Pro Phe Gly Lys Ile Asp 
625                 630                 635                 640 


Pro Phe Gly Gly Asp Pro Phe Lys Gly Ser Asp Pro Phe Ala Ser Asp 
                645                 650                 655     


Cys Phe Phe Arg Gln Ser Thr Asp Pro Phe Ala Thr Ser Ser Thr Asp 
            660                 665                 670         


Pro Phe Ser Ala Ala Asn Asn Ser Ser Ile Thr Ser Val Glu Thr Leu 
        675                 680                 685             


Lys His Asn Asp Pro Phe Ala Pro Gly Gly Thr Val Val Ala Ala Ser 
    690                 695                 700                 


Asp Ser Ala Thr Asp Pro Phe Ala Ser Val Phe Gly Asn Glu Ser Phe 
705                 710                 715                 720 


Gly Gly Gly Phe Ala Asp Phe Ser Thr Leu Ser Lys Val Asn Asn Glu 
                725                 730                 735     


Asp Pro Phe Arg Ser Ala Thr Ser Ser Ser Val Ser Asn Val Val Ile 
            740                 745                 750         


Thr Lys Asn Val Phe Glu Glu Thr Ser Val Lys Ser Glu Asp Glu Pro 
        755                 760                 765             


Pro Ala Leu Pro Pro Lys Ile Gly Thr Pro Thr Arg Pro Cys Pro Leu 
    770                 775                 780                 


Pro Pro Gly Lys Arg Ser Ile Asn Lys Leu Asp Ser Pro Asp Pro Phe 
785                 790                 795                 800 


Lys Leu Asn Asp Pro Phe Gln Pro Phe Pro Gly Asn Asp Ser Pro Lys 
                805                 810                 815     


Glu Lys Asp Pro Glu Ile Phe Cys Asp Pro Phe Thr Ser Ala Thr Thr 
            820                 825                 830         


Thr Thr Asn Lys Glu Ala Asp Pro Ser Asn Phe Ala Asn Phe Ser Ala 
        835                 840                 845             


Tyr Pro Ser Glu Glu Asp Met Ile Glu Trp Ala Lys Arg Glu Ser Glu 
    850                 855                 860                 


Arg Glu Glu Glu Gln Arg Leu Ala Arg Leu Asn Gln Gln Glu Gln Glu 
865                 870                 875                 880 


Asp Leu Glu Leu Ala Ile Ala Leu Ser Lys Ser Glu Ile Ser Glu Ala 
                885                 890                 895     


<210>  4842
<211>  90
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4842

Xaa Ala Ala Ala Gln Leu Ser Leu Thr Gln Leu Ser Ser Gly Asn Pro 
1               5                   10                  15      


Val Tyr Glu Lys Tyr Tyr Arg Gln Val Asp Thr Gly Asn Thr Gly Arg 
            20                  25                  30          


Val Leu Ala Ser Asp Ala Ala Ala Phe Leu Lys Lys Ser Gly Leu Pro 
        35                  40                  45              


Asp Leu Ile Leu Gly Lys Ile Trp Asp Leu Ala Asp Thr Asp Gly Lys 
    50                  55                  60                  


Gly Ile Leu Asn Lys Gln His Asp Thr Ser Ser Pro Leu Leu Ile Ser 
65                  70                  75                  80  


Gly Thr Ser Ala Ala Glu Leu Pro Trp Ala 
                85                  90  


<210>  4843
<211>  659
<212>  PRT
<213>  Homo Sapiens

<400>  4843

Met Asp Ser Gln Gly Arg Val Trp Ala Gln Glu Met Leu Leu Arg Val 
1               5                   10                  15      


Ser Pro Asp His Val Thr Leu Leu Asp Pro Ala Ser Lys Glu Glu Leu 
            20                  25                  30          


Glu Ser Tyr Pro Leu Gly Ala Ile Val Arg Cys Asp Ala Val Met Pro 
        35                  40                  45              


Pro Gly Arg Ser Arg Ser Leu Leu Leu Leu Val Cys Gln Glu Pro Glu 
    50                  55                  60                  


Arg Ala Gln Pro Asp Val His Phe Phe Gln Gly Leu Arg Leu Gly Ala 
65                  70                  75                  80  


Glu Leu Ile Arg Glu Asp Ile Gln Gly Ala Leu His Asn Tyr Arg Ser 
                85                  90                  95      


Gly Arg Gly Glu Arg Arg Ala Ala Ala Leu Arg Ala Thr Gln Glu Glu 
            100                 105                 110         


Leu Gln Arg Asp Arg Ser Pro Ala Ala Glu Thr Pro Pro Leu Gln Arg 
        115                 120                 125             


Arg Pro Ser Val Arg Ala Val Ile Ser Thr Val Glu Arg Gly Ala Gly 
    130                 135                 140                 


Arg Gly Arg Pro Gln Ala Lys Pro Ile Pro Glu Ala Glu Glu Ala Gln 
145                 150                 155                 160 


Arg Pro Glu Pro Val Gly Thr Ser Ser Asn Ala Asp Ser Ala Ser Pro 
                165                 170                 175     


Asp Leu Gly Pro Arg Gly Pro Asp Leu Ala Val Leu Gln Ala Glu Arg 
            180                 185                 190         


Glu Val Asp Ile Leu Asn His Val Phe Asp Asp Val Glu Ser Phe Val 
        195                 200                 205             


Ser Arg Leu Gln Lys Ser Ala Glu Ala Ala Arg Val Leu Glu His Arg 
    210                 215                 220                 


Glu Arg Gly Arg Arg Ser Arg Arg Arg Ala Ala Gly Glu Gly Leu Leu 
225                 230                 235                 240 


Thr Leu Arg Ala Lys Pro Pro Ser Glu Ala Glu Tyr Thr Asp Val Leu 
                245                 250                 255     


Gln Lys Ile Lys Tyr Ala Phe Ser Leu Leu Ala Arg Leu Arg Gly Asn 
            260                 265                 270         


Ile Ala Asp Pro Ser Ser Pro Glu Leu Leu His Phe Leu Phe Gly Pro 
        275                 280                 285             


Leu Gln Met Ile Val Asn Thr Ser Gly Gly Pro Glu Phe Ala Ser Ser 
    290                 295                 300                 


Val Arg Arg Pro His Leu Thr Ser Asp Ala Val Ala Leu Leu Arg Asp 
305                 310                 315                 320 


Asn Val Thr Pro Arg Glu Asn Glu Leu Trp Thr Ser Leu Gly Asp Ser 
                325                 330                 335     


Trp Thr Arg Pro Gly Leu Glu Leu Ser Pro Glu Glu Gly Pro Pro Tyr 
            340                 345                 350         


Arg Pro Glu Phe Phe Ser Gly Trp Glu Pro Pro Val Thr Asp Pro Gln 
        355                 360                 365             


Ser Arg Ala Trp Glu Asp Pro Val Glu Lys Gln Leu Gln His Glu Arg 
    370                 375                 380                 


Arg Arg Arg Gln Gln Ser Ala Pro Gln Val Ala Val Asn Gly His Arg 
385                 390                 395                 400 


Asp Leu Glu Pro Glu Ser Glu Pro Gln Leu Glu Ser Glu Thr Ala Gly 
                405                 410                 415     


Lys Trp Val Leu Cys Asn Tyr Asp Phe Gln Ala Arg Asn Ser Ser Glu 
            420                 425                 430         


Leu Ser Val Lys Gln Arg Asp Val Leu Glu Val Leu Asp Asp Ser Arg 
        435                 440                 445             


Lys Trp Trp Lys Val Arg Asp Pro Ala Gly Gln Glu Gly Tyr Val Pro 
    450                 455                 460                 


Tyr Asn Ile Leu Thr Pro Tyr Pro Gly Pro Arg Leu His His Ser Gln 
465                 470                 475                 480 


Ser Pro Ala Arg Ser Leu Asn Ser Thr Pro Pro Pro Pro Pro Ala Pro 
                485                 490                 495     


Ala Pro Ala Pro Pro Pro Ala Leu Ala Arg Pro Arg Trp Asp Arg Pro 
            500                 505                 510         


Arg Trp Asp Ser Cys Asp Ser Leu Asn Gly Leu Asp Pro Ser Glu Lys 
        515                 520                 525             


Glu Lys Phe Ser Gln Met Leu Ile Val Asn Glu Glu Leu Gln Ala Arg 
    530                 535                 540                 


Leu Ala Gln Gly Arg Ser Gly Pro Ser Arg Ala Val Pro Gly Pro Arg 
545                 550                 555                 560 


Ala Pro Glu Pro Gln Leu Ser Pro Gly Ser Asp Ala Ser Glu Val Arg 
                565                 570                 575     


Ala Trp Leu Gln Ala Lys Gly Phe Ser Ser Gly Thr Val Asp Ala Leu 
            580                 585                 590         


Gly Val Leu Thr Gly Ala Gln Leu Phe Ser Leu Gln Lys Glu Glu Leu 
        595                 600                 605             


Arg Ala Val Ser Pro Glu Glu Gly Ala Arg Val Tyr Ser Gln Val Thr 
    610                 615                 620                 


Val Gln Arg Ser Leu Leu Glu Asp Lys Glu Lys Val Ser Glu Leu Glu 
625                 630                 635                 640 


Ala Val Met Glu Lys Gln Lys Lys Lys Val Glu Gly Glu Val Glu Met 
                645                 650                 655     


Glu Val Ile 
            


<210>  4844
<211>  548
<212>  PRT
<213>  Homo Sapiens

<400>  4844

Met Gly Arg Lys Ala Ile Val Leu Ala Ile Ala Asn Thr Ser Leu Ala 
1               5                   10                  15      


Phe Pro Leu Cys Gln His Leu Val Thr Phe Cys Leu Gly Glu Asp Asp 
            20                  25                  30          


Gly Val His Thr Val Glu Asp Ala Ser Arg Lys Leu Ala Val Met Asp 
        35                  40                  45              


Ser Gln Gly Arg Val Trp Ala Gln Glu Met Leu Leu Arg Val Ser Pro 
    50                  55                  60                  


Asp His Val Thr Leu Leu Asp Pro Ala Ser Lys Glu Glu Leu Glu Ser 
65                  70                  75                  80  


Tyr Pro Leu Gly Ala Ile Val Arg Cys Asp Ala Val Met Pro Pro Gly 
                85                  90                  95      


Arg Ser Arg Ser Leu Leu Leu Leu Val Cys Gln Glu Pro Glu Arg Ala 
            100                 105                 110         


Gln Pro Asp Val His Phe Phe Gln Gly Leu Arg Leu Gly Ala Glu Leu 
        115                 120                 125             


Ile Arg Glu Asp Ile Gln Gly Ala Leu His Asn Tyr Arg Ser Gly Arg 
    130                 135                 140                 


Gly Glu Arg Arg Ala Ala Ala Leu Arg Ala Thr Gln Glu Glu Leu Gln 
145                 150                 155                 160 


Arg Asp Arg Ser Pro Ala Ala Glu Thr Pro Pro Leu Gln Arg Arg Pro 
                165                 170                 175     


Ser Val Arg Ala Val Ile Ser Thr Val Glu Arg Gly Ala Gly Arg Gly 
            180                 185                 190         


Arg Pro Gln Ala Lys Pro Ile Pro Glu Ala Glu Glu Ala Gln Arg Pro 
        195                 200                 205             


Glu Pro Val Gly Thr Ser Ser Asn Ala Asp Ser Ala Ser Pro Asp Leu 
    210                 215                 220                 


Gly Pro Arg Gly Pro Asp Leu Ala Val Leu Gln Ala Glu Arg Glu Val 
225                 230                 235                 240 


Asp Ile Leu Asn His Val Phe Asp Asp Val Glu Ser Phe Val Ser Arg 
                245                 250                 255     


Leu Gln Lys Ser Ala Glu Ala Ala Arg Val Leu Glu His Arg Glu Arg 
            260                 265                 270         


Gly Arg Arg Ser Arg Arg Arg Ala Ala Gly Glu Gly Leu Leu Thr Leu 
        275                 280                 285             


Arg Ala Lys Pro Pro Ser Glu Ala Glu Tyr Thr Asp Val Leu Gln Lys 
    290                 295                 300                 


Ile Lys Tyr Ala Phe Ser Leu Leu Ala Arg Leu Arg Gly Asn Ile Ala 
305                 310                 315                 320 


Asp Pro Ser Ser Pro Glu Leu Leu His Phe Leu Phe Gly Pro Leu Gln 
                325                 330                 335     


Met Ile Val Asn Thr Ser Gly Gly Pro Glu Phe Ala Ser Ser Val Arg 
            340                 345                 350         


Arg Pro His Leu Thr Ser Asp Ala Val Ala Leu Leu Arg Asp Asn Val 
        355                 360                 365             


Thr Pro Arg Glu Asn Glu Leu Trp Thr Ser Leu Gly Asp Ser Trp Thr 
    370                 375                 380                 


Arg Pro Gly Leu Glu Leu Ser Pro Glu Glu Gly Pro Pro Tyr Arg Pro 
385                 390                 395                 400 


Glu Phe Phe Ser Gly Trp Glu Pro Pro Val Thr Asp Pro Gln Ser Arg 
                405                 410                 415     


Ala Trp Glu Asp Pro Val Glu Lys Gln Leu Gln His Glu Arg Arg Arg 
            420                 425                 430         


Arg Gln Val Thr Gln Ala Thr Gln Gln Gly Arg Gly Trp Glu Val Arg 
        435                 440                 445             


Gly Arg Gly Arg Ser Ala Trp Pro Arg Leu Thr Arg Leu Ser Tyr Phe 
    450                 455                 460                 


Leu Gln Gln Ser Ala Pro Gln Val Ala Val Asn Gly His Arg Asp Leu 
465                 470                 475                 480 


Glu Pro Glu Ser Glu Pro Gln Leu Glu Ser Glu Thr Ala Gly Lys Trp 
                485                 490                 495     


Val Leu Cys Asn Tyr Asp Phe Gln Ala Arg Asn Ser Ser Glu Leu Ser 
            500                 505                 510         


Val Lys Gln Arg Asp Val Leu Glu Asp Lys Glu Lys Val Ser Glu Leu 
        515                 520                 525             


Glu Ala Val Met Glu Lys Gln Lys Lys Lys Val Glu Gly Glu Val Glu 
    530                 535                 540                 


Met Glu Val Ile 
545             


<210>  4845
<211>  428
<212>  PRT
<213>  Homo Sapiens

<400>  4845

Met His Leu Val Thr Phe Cys Leu Gly Glu Asp Asp Gly Val His Thr 
1               5                   10                  15      


Val Glu Asp Ala Ser Arg Lys Leu Ala Val Met Asp Ser Gln Gly Arg 
            20                  25                  30          


Val Trp Ala Gln Glu Met Leu Leu Arg Val Ser Pro Asp His Val Thr 
        35                  40                  45              


Leu Leu Asp Pro Ala Ser Lys Glu Glu Leu Glu Ser Tyr Pro Leu Gly 
    50                  55                  60                  


Ala Ile Val Arg Cys Asp Ala Val Met Pro Pro Gly Arg Ser Arg Ser 
65                  70                  75                  80  


Leu Leu Leu Leu Val Cys Gln Glu Pro Glu Arg Ala Gln Pro Asp Val 
                85                  90                  95      


His Phe Phe Gln Gly Leu Arg Leu Gly Ala Glu Leu Ile Arg Glu Asp 
            100                 105                 110         


Ile Gln Gly Ala Leu His Asn Tyr Arg Ser Gly Arg Gly Glu Arg Arg 
        115                 120                 125             


Ala Ala Ala Leu Arg Ala Thr Gln Glu Glu Leu Gln Arg Asp Arg Ser 
    130                 135                 140                 


Pro Ala Ala Glu Thr Pro Pro Leu Gln Arg Arg Pro Ser Val Arg Ala 
145                 150                 155                 160 


Val Ile Ser Thr Val Glu Arg Gly Ala Gly Arg Gly Arg Pro Gln Ala 
                165                 170                 175     


Lys Pro Ile Pro Glu Ala Glu Glu Ala Gln Arg Pro Glu Pro Val Gly 
            180                 185                 190         


Thr Ser Ser Asn Ala Asp Ser Ala Ser Pro Asp Leu Gly Pro Arg Gly 
        195                 200                 205             


Pro Asp Leu Ala Val Leu Gln Ala Glu Arg Glu Val Asp Ile Leu Asn 
    210                 215                 220                 


His Val Phe Asp Asp Val Glu Ser Phe Val Ser Arg Leu Gln Lys Ser 
225                 230                 235                 240 


Ala Glu Ala Ala Arg Val Leu Glu His Arg Glu Arg Gly Arg Arg Ser 
                245                 250                 255     


Arg Arg Arg Ala Ala Gly Glu Gly Leu Leu Thr Leu Arg Ala Lys Pro 
            260                 265                 270         


Pro Ser Glu Ala Glu Tyr Thr Asp Val Leu Gln Lys Ile Lys Tyr Ala 
        275                 280                 285             


Phe Ser Leu Leu Ala Arg Leu Arg Gly Asn Ile Ala Asp Pro Ser Ser 
    290                 295                 300                 


Pro Glu Leu Leu His Phe Leu Phe Gly Pro Leu Gln Met Ile Val Asn 
305                 310                 315                 320 


Thr Ser Gly Gly Pro Glu Phe Ala Ser Ser Val Arg Arg Pro His Leu 
                325                 330                 335     


Thr Ser Asp Ala Val Ala Leu Leu Arg Asp Asn Val Thr Pro Arg Glu 
            340                 345                 350         


Asn Glu Leu Trp Thr Ser Leu Gly Asp Ser Trp Thr Arg Pro Gly Leu 
        355                 360                 365             


Glu Leu Ser Pro Glu Glu Gly Pro Pro Tyr Arg Pro Glu Phe Phe Ser 
    370                 375                 380                 


Gly Trp Glu Pro Pro Val Thr Asp Pro Gln Ser Arg Ala Trp Glu Asp 
385                 390                 395                 400 


Pro Val Glu Lys Gln Leu Gln His Glu Arg Arg Arg Arg Gln Gln Ser 
                405                 410                 415     


Ala Pro Gln Val Ala Val Asn Gly Trp Val Arg Trp 
            420                 425             


<210>  4846
<211>  596
<212>  PRT
<213>  Homo Sapiens

<400>  4846

Met Asn Arg Thr Trp Pro Arg Arg Ile Trp Gly Ser Ser Gln Asp Glu 
1               5                   10                  15      


Ala Glu Leu Ile Arg Glu Asp Ile Gln Gly Ala Leu His Asn Tyr Arg 
            20                  25                  30          


Ser Gly Arg Gly Glu Arg Arg Ala Ala Ala Leu Arg Ala Thr Gln Glu 
        35                  40                  45              


Glu Leu Gln Arg Asp Arg Ser Pro Ala Ala Glu Thr Pro Pro Leu Gln 
    50                  55                  60                  


Arg Arg Pro Ser Val Arg Ala Val Ile Ser Thr Val Glu Arg Gly Ala 
65                  70                  75                  80  


Gly Arg Gly Arg Pro Gln Ala Lys Pro Ile Pro Glu Ala Glu Glu Ala 
                85                  90                  95      


Gln Arg Pro Glu Pro Val Gly Thr Ser Ser Asn Ala Asp Ser Ala Ser 
            100                 105                 110         


Pro Asp Leu Gly Pro Arg Gly Pro Asp Leu Ala Val Leu Gln Ala Glu 
        115                 120                 125             


Arg Glu Val Asp Ile Leu Asn His Val Phe Asp Asp Val Glu Ser Phe 
    130                 135                 140                 


Val Ser Arg Leu Gln Lys Ser Ala Glu Ala Ala Arg Val Leu Glu His 
145                 150                 155                 160 


Arg Glu Arg Gly Arg Arg Ser Arg Arg Arg Ala Ala Gly Glu Gly Leu 
                165                 170                 175     


Leu Thr Leu Arg Ala Lys Pro Pro Ser Glu Ala Glu Tyr Thr Asp Val 
            180                 185                 190         


Leu Gln Lys Ile Lys Tyr Ala Phe Ser Leu Leu Ala Arg Leu Arg Gly 
        195                 200                 205             


Asn Ile Ala Asp Pro Ser Ser Pro Glu Leu Leu His Phe Leu Phe Gly 
    210                 215                 220                 


Pro Leu Gln Met Ile Val Asn Thr Ser Gly Gly Pro Glu Phe Ala Ser 
225                 230                 235                 240 


Ser Val Arg Arg Pro His Leu Thr Ser Asp Ala Val Ala Leu Leu Arg 
                245                 250                 255     


Asp Asn Val Thr Pro Arg Glu Asn Glu Leu Trp Thr Ser Leu Gly Asp 
            260                 265                 270         


Ser Trp Thr Arg Pro Gly Leu Glu Leu Ser Pro Glu Glu Gly Pro Pro 
        275                 280                 285             


Tyr Arg Pro Glu Phe Phe Ser Gly Trp Glu Pro Pro Val Thr Asp Pro 
    290                 295                 300                 


Gln Ser Arg Ala Trp Glu Asp Pro Val Glu Lys Gln Leu Gln His Glu 
305                 310                 315                 320 


Arg Arg Arg Arg Gln Gln Ser Ala Pro Gln Val Ala Val Asn Gly His 
                325                 330                 335     


Arg Asp Leu Glu Pro Glu Ser Glu Pro Gln Leu Glu Ser Glu Thr Ala 
            340                 345                 350         


Gly Lys Trp Val Leu Cys Asn Tyr Asp Phe Gln Ala Arg Asn Ser Ser 
        355                 360                 365             


Glu Leu Ser Val Lys Gln Arg Asp Val Leu Glu Val Leu Asp Asp Ser 
    370                 375                 380                 


Arg Lys Trp Trp Lys Val Arg Asp Pro Ala Gly Gln Glu Gly Tyr Val 
385                 390                 395                 400 


Pro Tyr Asn Ile Leu Thr Pro Tyr Pro Gly Pro Arg Leu His His Ser 
                405                 410                 415     


Gln Ser Pro Ala Arg Ser Leu Asn Ser Thr Pro Pro Pro Pro Pro Ala 
            420                 425                 430         


Pro Ala Pro Ala Pro Pro Pro Ala Leu Ala Arg Pro Arg Trp Asp Arg 
        435                 440                 445             


Pro Arg Trp Asp Ser Cys Asp Ser Leu Asn Gly Leu Asp Pro Ser Glu 
    450                 455                 460                 


Lys Glu Lys Phe Ser Gln Met Leu Ile Val Asn Glu Glu Leu Gln Ala 
465                 470                 475                 480 


Arg Leu Ala Gln Gly Arg Ser Gly Pro Ser Arg Ala Val Pro Gly Pro 
                485                 490                 495     


Arg Ala Pro Glu Pro Gln Leu Ser Pro Gly Ser Asp Ala Ser Glu Val 
            500                 505                 510         


Arg Ala Trp Leu Gln Ala Lys Gly Phe Ser Ser Gly Thr Val Asp Ala 
        515                 520                 525             


Leu Gly Val Leu Thr Gly Ala Gln Leu Phe Ser Leu Gln Lys Glu Glu 
    530                 535                 540                 


Leu Arg Ala Val Ser Pro Glu Glu Gly Ala Arg Val Tyr Ser Gln Val 
545                 550                 555                 560 


Thr Val Gln Arg Ser Leu Leu Glu Asp Lys Glu Lys Val Ser Glu Leu 
                565                 570                 575     


Glu Ala Val Met Glu Lys Gln Lys Lys Lys Val Glu Gly Glu Val Glu 
            580                 585                 590         


Met Glu Val Ile 
        595     


<210>  4847
<211>  409
<212>  PRT
<213>  Homo Sapiens

<400>  4847

Met Asn Arg Thr Trp Pro Arg Arg Ile Trp Gly Ser Ser Gln Asp Glu 
1               5                   10                  15      


Val Gly Phe Ala Ser Ser Val Arg Arg Pro His Leu Thr Ser Asp Ala 
            20                  25                  30          


Val Ala Leu Leu Arg Asp Asn Val Thr Pro Arg Glu Asn Glu Leu Trp 
        35                  40                  45              


Thr Ser Leu Gly Asp Ser Trp Thr Arg Pro Gly Leu Glu Leu Ser Pro 
    50                  55                  60                  


Glu Glu Gly Pro Pro Tyr Arg Pro Glu Phe Phe Ser Gly Trp Glu Pro 
65                  70                  75                  80  


Pro Val Thr Asp Pro Gln Ser Arg Ala Trp Glu Asp Pro Val Glu Lys 
                85                  90                  95      


Gln Leu Gln His Glu Arg Arg Arg Arg Gln Val Thr Gln Ala Thr Gln 
            100                 105                 110         


Gln Gly Arg Gly Trp Glu Val Arg Gly Arg Gly Arg Ser Ala Trp Pro 
        115                 120                 125             


Arg Leu Thr Arg Leu Ser Tyr Phe Leu Gln Gln Ser Ala Pro Gln Val 
    130                 135                 140                 


Ala Val Asn Gly His Arg Asp Leu Glu Pro Glu Ser Glu Pro Gln Leu 
145                 150                 155                 160 


Glu Ser Glu Thr Ala Gly Lys Trp Val Leu Cys Asn Tyr Asp Phe Gln 
                165                 170                 175     


Ala Arg Asn Ser Ser Glu Leu Ser Val Lys Gln Arg Asp Val Leu Glu 
            180                 185                 190         


Val Leu Asp Asp Ser Arg Lys Trp Trp Lys Val Arg Asp Pro Ala Gly 
        195                 200                 205             


Gln Glu Gly Tyr Val Pro Tyr Asn Ile Leu Thr Pro Tyr Pro Gly Pro 
    210                 215                 220                 


Arg Leu His His Ser Gln Ser Pro Ala Arg Ser Leu Asn Ser Thr Pro 
225                 230                 235                 240 


Pro Pro Pro Pro Ala Pro Ala Pro Ala Pro Pro Pro Ala Leu Ala Arg 
                245                 250                 255     


Pro Arg Trp Asp Arg Pro Arg Trp Asp Ser Cys Asp Ser Leu Asn Gly 
            260                 265                 270         


Leu Asp Pro Ser Glu Lys Glu Lys Phe Ser Gln Met Leu Ile Val Asn 
        275                 280                 285             


Glu Glu Leu Gln Ala Arg Leu Ala Gln Gly Arg Ser Gly Pro Ser Arg 
    290                 295                 300                 


Ala Val Pro Gly Pro Arg Ala Pro Glu Pro Gln Leu Ser Pro Gly Ser 
305                 310                 315                 320 


Asp Ala Ser Glu Val Arg Ala Trp Leu Gln Ala Lys Gly Phe Ser Ser 
                325                 330                 335     


Gly Thr Val Asp Ala Leu Gly Val Leu Thr Gly Ala Gln Leu Phe Ser 
            340                 345                 350         


Leu Gln Lys Glu Glu Leu Arg Ala Val Ser Pro Glu Glu Gly Ala Arg 
        355                 360                 365             


Val Tyr Ser Gln Val Thr Val Gln Arg Ser Leu Leu Glu Asp Lys Glu 
    370                 375                 380                 


Lys Val Ser Glu Leu Glu Ala Val Met Glu Lys Gln Lys Lys Lys Val 
385                 390                 395                 400 


Glu Gly Glu Val Glu Met Glu Val Ile 
                405                 


<210>  4848
<211>  723
<212>  PRT
<213>  Homo Sapiens

<400>  4848

Met Ser Thr Ala Thr Gly Pro Glu Ala Ala Pro Lys Pro Ser Ala Lys 
1               5                   10                  15      


Ser Ile Tyr Glu Gln Arg Lys Arg Tyr Ser Thr Val Val Met Ala Asp 
            20                  25                  30          


Val Ser Gln Tyr Pro Val Asn His Leu Val Thr Phe Cys Leu Gly Glu 
        35                  40                  45              


Asp Asp Gly Val His Thr Val Glu Asp Ala Ser Arg Lys Leu Ala Val 
    50                  55                  60                  


Met Asp Ser Gln Gly Arg Val Trp Ala Gln Glu Met Leu Leu Arg Val 
65                  70                  75                  80  


Ser Pro Asp His Val Thr Leu Leu Asp Pro Ala Ser Lys Glu Glu Leu 
                85                  90                  95      


Glu Ser Tyr Pro Leu Gly Ala Ile Val Arg Cys Asp Ala Val Met Pro 
            100                 105                 110         


Pro Gly Arg Ser Arg Ser Leu Leu Leu Leu Val Cys Gln Glu Pro Glu 
        115                 120                 125             


Arg Ala Gln Pro Asp Val His Phe Phe Gln Gly Leu Arg Leu Gly Ala 
    130                 135                 140                 


Glu Leu Ile Arg Glu Asp Ile Gln Gly Ala Leu His Asn Tyr Arg Ser 
145                 150                 155                 160 


Gly Arg Gly Glu Arg Arg Ala Ala Ala Leu Arg Ala Thr Gln Glu Glu 
                165                 170                 175     


Leu Gln Arg Asp Arg Ser Pro Ala Ala Glu Thr Pro Pro Leu Gln Arg 
            180                 185                 190         


Arg Pro Ser Val Arg Ala Val Ile Ser Thr Val Glu Arg Gly Ala Gly 
        195                 200                 205             


Arg Gly Arg Pro Gln Ala Lys Pro Ile Pro Glu Ala Glu Glu Ala Gln 
    210                 215                 220                 


Arg Pro Glu Pro Val Gly Thr Ser Ser Asn Ala Asp Ser Ala Ser Pro 
225                 230                 235                 240 


Asp Leu Gly Pro Arg Gly Pro Asp Leu Ala Val Leu Gln Ala Glu Arg 
                245                 250                 255     


Glu Val Asp Ile Leu Asn His Val Phe Asp Asp Val Glu Ser Phe Val 
            260                 265                 270         


Ser Arg Leu Gln Lys Ser Ala Glu Ala Ala Arg Val Leu Glu His Arg 
        275                 280                 285             


Glu Arg Gly Arg Arg Ser Arg Arg Arg Ala Ala Gly Glu Gly Leu Leu 
    290                 295                 300                 


Thr Leu Arg Ala Lys Pro Pro Ser Glu Ala Glu Tyr Thr Asp Val Leu 
305                 310                 315                 320 


Gln Lys Ile Lys Tyr Ala Phe Ser Leu Leu Ala Arg Leu Arg Gly Asn 
                325                 330                 335     


Ile Ala Asp Pro Ser Ser Pro Glu Leu Leu His Phe Leu Phe Gly Pro 
            340                 345                 350         


Leu Gln Met Ile Val Asn Thr Ser Gly Gly Pro Glu Phe Ala Ser Ser 
        355                 360                 365             


Val Arg Arg Pro His Leu Thr Ser Asp Ala Val Ala Leu Leu Arg Asp 
    370                 375                 380                 


Asn Val Thr Pro Arg Glu Asn Glu Leu Trp Thr Ser Leu Gly Asp Ser 
385                 390                 395                 400 


Trp Thr Arg Pro Gly Leu Glu Leu Ser Pro Glu Glu Gly Pro Pro Tyr 
                405                 410                 415     


Arg Pro Glu Phe Phe Ser Gly Trp Glu Pro Pro Val Thr Asp Pro Gln 
            420                 425                 430         


Ser Arg Ala Trp Glu Asp Pro Val Glu Lys Gln Leu Gln His Glu Arg 
        435                 440                 445             


Arg Arg Arg Gln Gln Ser Ala Pro Gln Val Ala Val Asn Gly His Arg 
    450                 455                 460                 


Asp Leu Glu Pro Glu Ser Glu Pro Gln Leu Glu Ser Glu Thr Ala Gly 
465                 470                 475                 480 


Lys Trp Val Leu Cys Asn Tyr Asp Phe Gln Ala Arg Asn Ser Ser Glu 
                485                 490                 495     


Leu Ser Val Lys Gln Arg Asp Val Leu Glu Val Leu Asp Asp Ser Arg 
            500                 505                 510         


Lys Trp Trp Lys Val Arg Asp Pro Ala Gly Gln Glu Gly Tyr Val Pro 
        515                 520                 525             


Tyr Asn Ile Leu Thr Pro Tyr Pro Gly Pro Arg Leu His His Ser Gln 
    530                 535                 540                 


Ser Pro Ala Arg Ser Leu Asn Ser Thr Pro Pro Pro Pro Pro Ala Pro 
545                 550                 555                 560 


Ala Pro Ala Pro Pro Pro Ala Leu Ala Arg Pro Arg Trp Asp Arg Pro 
                565                 570                 575     


Arg Trp Asp Ser Cys Asp Ser Leu Asn Gly Leu Asp Pro Ser Glu Lys 
            580                 585                 590         


Glu Lys Phe Ser Gln Met Leu Ile Val Asn Glu Glu Leu Gln Ala Arg 
        595                 600                 605             


Leu Ala Gln Gly Arg Ser Gly Pro Ser Arg Ala Val Pro Gly Pro Arg 
    610                 615                 620                 


Ala Pro Glu Pro Gln Leu Ser Pro Gly Ser Asp Ala Ser Glu Val Arg 
625                 630                 635                 640 


Ala Trp Leu Gln Ala Lys Gly Phe Ser Ser Gly Thr Val Asp Ala Leu 
                645                 650                 655     


Gly Val Leu Thr Gly Ala Gln Leu Phe Ser Leu Gln Lys Glu Glu Leu 
            660                 665                 670         


Arg Ala Val Ser Pro Glu Glu Gly Ala Arg Val Tyr Ser Gln Val Thr 
        675                 680                 685             


Val Gln Arg Ser Leu Leu Glu Asp Lys Glu Lys Val Ser Glu Leu Glu 
    690                 695                 700                 


Ala Val Met Glu Lys Gln Lys Lys Lys Val Glu Gly Glu Val Glu Met 
705                 710                 715                 720 


Glu Val Ile 
            


<210>  4849
<211>  715
<212>  PRT
<213>  Homo Sapiens

<400>  4849

Met His Leu Leu Pro Ala Leu Ala Gly Val Leu Ala Thr Leu Val Leu 
1               5                   10                  15      


Ala Gln Pro Cys Glu Gly Thr Asp Pro Ala Ser Pro Gly Ala Val Glu 
            20                  25                  30          


Thr Ser Val Leu Arg Asp Cys Ile Ala Glu Ala Lys Leu Leu Val Asp 
        35                  40                  45              


Ala Ala Tyr Asn Trp Thr Gln Lys Ser Ile Lys Gln Arg Leu Arg Ser 
    50                  55                  60                  


Gly Ser Ala Ser Pro Met Asp Leu Leu Ser Tyr Phe Lys Gln Pro Val 
65                  70                  75                  80  


Ala Ala Thr Arg Thr Val Val Arg Ala Ala Asp Tyr Met His Val Ala 
                85                  90                  95      


Leu Gly Leu Leu Glu Glu Lys Leu Gln Pro Gln Arg Ser Gly Pro Phe 
            100                 105                 110         


Asn Val Thr Asp Val Leu Thr Glu Pro Gln Leu Arg Leu Leu Ser Gln 
        115                 120                 125             


Ala Ser Gly Cys Ala Leu Arg Asp Gln Ala Glu Arg Cys Ser Asp Lys 
    130                 135                 140                 


Tyr Arg Thr Ile Thr Gly Arg Cys Asn Asn Lys Arg Arg Pro Leu Leu 
145                 150                 155                 160 


Gly Ala Ser Asn Gln Ala Leu Ala Arg Trp Leu Pro Ala Glu Tyr Glu 
                165                 170                 175     


Asp Gly Leu Ser Leu Pro Phe Gly Trp Thr Pro Ser Arg Arg Arg Asn 
            180                 185                 190         


Gly Phe Leu Leu Pro Leu Val Arg Ala Val Ser Asn Gln Ile Val Arg 
        195                 200                 205             


Phe Pro Asn Glu Arg Leu Thr Ser Asp Arg Gly Arg Ala Leu Met Phe 
    210                 215                 220                 


Met Gln Trp Gly Gln Phe Ile Asp His Asp Leu Asp Phe Ser Pro Glu 
225                 230                 235                 240 


Ser Pro Ala Arg Val Ala Phe Thr Ala Gly Val Asp Cys Glu Arg Thr 
                245                 250                 255     


Cys Ala Gln Leu Pro Pro Cys Phe Pro Ile Lys Ile Pro Pro Asn Asp 
            260                 265                 270         


Pro Arg Ile Lys Asn Gln Arg Asp Cys Ile Pro Phe Phe Arg Ser Ala 
        275                 280                 285             


Pro Ser Cys Pro Gln Asn Lys Asn Arg Val Arg Asn Gln Ile Asn Ala 
    290                 295                 300                 


Leu Thr Ser Phe Val Asp Ala Ser Met Val Tyr Gly Ser Glu Val Ser 
305                 310                 315                 320 


Leu Ser Leu Arg Leu Arg Asn Arg Thr Asn Tyr Leu Gly Leu Leu Ala 
                325                 330                 335     


Ile Asn Gln Arg Phe Gln Asp Asn Gly Arg Ala Leu Leu Pro Phe Asp 
            340                 345                 350         


Asn Leu His Asp Asp Pro Cys Leu Leu Thr Asn Arg Ser Ala Arg Ile 
        355                 360                 365             


Pro Cys Phe Leu Ala Gly Asp Thr Arg Ser Thr Glu Thr Pro Lys Leu 
    370                 375                 380                 


Ala Ala Met His Thr Leu Phe Met Arg Glu His Asn Arg Leu Ala Thr 
385                 390                 395                 400 


Glu Leu Arg Arg Leu Asn Pro Arg Trp Asn Gly Asp Lys Leu Tyr Asn 
                405                 410                 415     


Glu Ala Arg Lys Ile Met Gly Ala Met Val Gln Ile Ile Thr Tyr Arg 
            420                 425                 430         


Asp Phe Leu Pro Leu Val Leu Gly Lys Ala Arg Ala Arg Arg Thr Leu 
        435                 440                 445             


Gly His Tyr Arg Gly Tyr Cys Ser Asn Val Asp Pro Arg Val Ala Asn 
    450                 455                 460                 


Val Phe Thr Leu Ala Phe Arg Phe Gly His Thr Met Leu Gln Pro Phe 
465                 470                 475                 480 


Met Phe Arg Leu Asp Ser Gln Tyr Arg Ala Ser Ala Pro Asn Ser His 
                485                 490                 495     


Val Pro Leu Ser Ser Ala Phe Phe Ala Ser Trp Arg Ile Val Tyr Glu 
            500                 505                 510         


Gly Gly Ile Asp Pro Ile Leu Arg Gly Leu Met Ala Thr Pro Ala Lys 
        515                 520                 525             


Leu Asn Arg Gln Asp Ala Met Leu Val Asp Glu Leu Arg Asp Arg Leu 
    530                 535                 540                 


Phe Arg Gln Val Arg Arg Ile Gly Leu Asp Leu Ala Ala Leu Asn Met 
545                 550                 555                 560 


Gln Arg Ser Arg Asp His Gly Leu Pro Gly Tyr Asn Ala Trp Arg Arg 
                565                 570                 575     


Phe Cys Gly Leu Ser Gln Pro Arg Asn Leu Ala Gln Leu Ser Arg Val 
            580                 585                 590         


Leu Lys Asn Gln Asp Leu Ala Arg Lys Phe Leu Asn Leu Tyr Gly Thr 
        595                 600                 605             


Pro Asp Asn Ile Asp Ile Trp Ile Gly Ala Ile Ala Glu Pro Leu Leu 
    610                 615                 620                 


Pro Gly Ala Arg Val Gly Pro Leu Leu Ala Cys Leu Phe Glu Asn Gln 
625                 630                 635                 640 


Phe Arg Arg Ala Arg Asp Gly Asp Arg Phe Trp Trp Gln Lys Arg Gly 
                645                 650                 655     


Val Phe Thr Lys Arg Gln Arg Lys Ala Leu Ser Arg Ile Ser Leu Ser 
            660                 665                 670         


Arg Ile Ile Cys Asp Asn Thr Gly Ile Thr Thr Val Ser Arg Asp Ile 
        675                 680                 685             


Phe Arg Ala Asn Ile Tyr Pro Arg Gly Phe Val Asn Cys Ser Arg Ile 
    690                 695                 700                 


Pro Arg Leu Asn Leu Ser Ala Trp Arg Gly Thr 
705                 710                 715 


<210>  4850
<211>  234
<212>  PRT
<213>  Homo Sapiens

<400>  4850

Met Lys Thr Leu Ala Gly Leu Val Leu Gly Leu Val Ile Phe Asp Ala 
1               5                   10                  15      


Ala Val Thr Ala Pro Thr Leu Glu Ser Ile Asn Tyr Asp Ser Glu Thr 
            20                  25                  30          


Tyr Asp Ala Thr Leu Glu Asp Leu Asp Asn Leu Tyr Asn Tyr Glu Asn 
        35                  40                  45              


Ile Pro Val Asp Lys Val Glu Ile Glu Ile Ala Thr Val Met Pro Ser 
    50                  55                  60                  


Gly Asn Arg Glu Leu Leu Thr Pro Pro Pro Gln Pro Glu Lys Ala Gln 
65                  70                  75                  80  


Glu Glu Glu Glu Glu Glu Glu Ser Thr Pro Arg Leu Ile Asp Gly Ser 
                85                  90                  95      


Ser Pro Gln Glu Pro Glu Phe Thr Gly Val Leu Gly Pro His Thr Asn 
            100                 105                 110         


Glu Asp Phe Pro Thr Cys Leu Leu Cys Thr Cys Ile Ser Thr Thr Val 
        115                 120                 125             


Tyr Cys Asp Asp His Glu Leu Asp Ala Ile Pro Pro Leu Pro Lys Asn 
    130                 135                 140                 


Thr Ala Tyr Phe Tyr Ser Arg Phe Asn Arg Ile Lys Lys Ile Asn Lys 
145                 150                 155                 160 


Asn Asp Phe Ala Ser Leu Ser Asp Leu Lys Arg Ile Asp Leu Thr Ser 
                165                 170                 175     


Asn Leu Ile Ser Glu Ile Asp Glu Asp Ala Phe Arg Lys Leu Pro Gln 
            180                 185                 190         


Leu Arg Glu Leu Val Leu Arg Asp Asn Lys Ile Arg Gln Leu Pro Glu 
        195                 200                 205             


Leu Pro Thr Thr Leu Thr Phe Ile Asp Ile Ser Asn Asn Arg Leu Gly 
    210                 215                 220                 


Arg Lys Gly Ile Lys Gln Glu Ala Phe Lys 
225                 230                 


<210>  4851
<211>  322
<212>  PRT
<213>  Homo Sapiens

<400>  4851

Met Lys Thr Leu Ala Gly Leu Val Leu Gly Leu Val Ile Phe Asp Ala 
1               5                   10                  15      


Ala Val Thr Ala Pro Thr Leu Glu Ser Ile Asn Tyr Asp Ser Glu Thr 
            20                  25                  30          


Tyr Asp Ala Thr Leu Glu Asp Leu Asp Asn Leu Tyr Asn Tyr Glu Asn 
        35                  40                  45              


Ile Pro Val Asp Lys Val Glu Ile Glu Ile Ala Thr Val Met Pro Ser 
    50                  55                  60                  


Gly Asn Arg Glu Leu Leu Thr Pro Pro Pro Gln Pro Glu Lys Ala Gln 
65                  70                  75                  80  


Glu Glu Glu Glu Glu Glu Glu Ser Thr Pro Arg Leu Ile Asp Gly Ser 
                85                  90                  95      


Ser Pro Gln Glu Pro Glu Phe Thr Gly Val Leu Gly Pro His Thr Asn 
            100                 105                 110         


Glu Asp Phe Pro Thr Cys Leu Leu Cys Thr Cys Ile Ser Thr Thr Val 
        115                 120                 125             


Tyr Cys Asp Asp His Glu Leu Asp Ala Ile Pro Pro Leu Pro Lys Asn 
    130                 135                 140                 


Thr Ala Tyr Phe Tyr Ser Arg Phe Asn Arg Ile Lys Lys Ile Asn Lys 
145                 150                 155                 160 


Asn Asp Phe Ala Ser Leu Ser Asp Leu Lys Arg Ile Asp Leu Thr Ser 
                165                 170                 175     


Asn Leu Ile Ser Glu Ile Asp Glu Asp Ala Phe Arg Lys Leu Pro Gln 
            180                 185                 190         


Leu Arg Glu Leu Val Leu Arg Asp Asn Lys Ile Arg Gln Leu Pro Glu 
        195                 200                 205             


Leu Pro Thr Thr Leu Thr Phe Ile Asp Ile Ser Asn Asn Arg Leu Gly 
    210                 215                 220                 


Arg Lys Gly Ile Lys Gln Glu Ala Phe Lys Asp Met Tyr Asp Leu His 
225                 230                 235                 240 


His Leu Tyr Leu Thr Asp Asn Asn Leu Asp His Ile Pro Leu Pro Leu 
                245                 250                 255     


Pro Glu Asn Leu Arg Ala Leu His Leu Gln Asn Asn Asn Ile Leu Glu 
            260                 265                 270         


Met His Glu Asp Thr Phe Cys Asn Val Lys Asn Leu Thr Tyr Ile Arg 
        275                 280                 285             


Lys Ala Leu Glu Asp Ile Arg Leu Asp Gly Asn Pro Ile Asn Leu Ser 
    290                 295                 300                 


Lys Thr Pro Gln Ala Tyr Met Cys Leu Pro Arg Leu Pro Val Gly Ser 
305                 310                 315                 320 


Leu Val 
        


<210>  4852
<211>  294
<212>  PRT
<213>  Homo Sapiens

<400>  4852

Met Asn Phe Ile Leu Phe Ile Phe Ile Pro Gly Val Phe Ser Leu Lys 
1               5                   10                  15      


Ser Ser Thr Leu Lys Pro Thr Ile Glu Ala Leu Pro Asn Val Leu Pro 
            20                  25                  30          


Leu Asn Glu Asp Val Asn Lys Gln Glu Glu Lys Asn Glu Asp His Thr 
        35                  40                  45              


Pro Asn Tyr Ala Pro Ala Asn Glu Lys Asn Gly Asn Tyr Tyr Lys Asp 
    50                  55                  60                  


Ile Lys Gln Tyr Val Phe Thr Thr Gln Asn Pro Asn Gly Thr Glu Ser 
65                  70                  75                  80  


Glu Ile Ser Val Arg Ala Thr Thr Asp Leu Asn Phe Ala Leu Lys Asn 
                85                  90                  95      


Asp Lys Thr Val Asn Ala Thr Thr Tyr Glu Lys Ser Thr Ile Glu Glu 
            100                 105                 110         


Glu Thr Thr Thr Ser Glu Pro Ser His Lys Asn Ile Gln Arg Ser Thr 
        115                 120                 125             


Pro Asn Val Pro Ala Phe Trp Thr Met Leu Ala Lys Ala Ile Asn Gly 
    130                 135                 140                 


Thr Ala Val Val Met Asp Asp Lys Asp Gln Leu Phe His Pro Ile Pro 
145                 150                 155                 160 


Glu Ser Asp Val Asn Ala Thr Gln Gly Glu Asn Gln Pro Asp Leu Glu 
                165                 170                 175     


Asp Leu Lys Ile Lys Ile Met Leu Gly Ile Ser Leu Met Thr Leu Leu 
            180                 185                 190         


Leu Phe Val Val Leu Leu Ala Phe Cys Ser Ala Thr Leu Tyr Lys Leu 
        195                 200                 205             


Arg His Leu Ser Tyr Lys Ser Cys Glu Ser Gln Tyr Ser Val Asn Pro 
    210                 215                 220                 


Glu Leu Ala Thr Met Ser Tyr Phe His Pro Ser Glu Gly Val Ser Asp 
225                 230                 235                 240 


Thr Ser Phe Ser Lys Ser Ala Glu Ser Ser Thr Phe Leu Gly Thr Thr 
                245                 250                 255     


Ser Ser Asp Met Arg Arg Ser Gly Thr Arg Thr Ser Glu Ser Lys Ile 
            260                 265                 270         


Met Thr Asp Ile Ile Ser Ile Gly Ser Asp Asn Glu Met His Glu Asn 
        275                 280                 285             


Asp Glu Ser Val Thr Arg 
    290                 


<210>  4853
<211>  127
<212>  PRT
<213>  Homo Sapiens

<400>  4853

Met Asn Phe Ile Leu Phe Ile Phe Ile Pro Gly Val Phe Ser Leu Lys 
1               5                   10                  15      


Ser Ser Thr Leu Lys Pro Thr Ile Glu Ala Leu Pro Asn Val Leu Pro 
            20                  25                  30          


Leu Asn Glu Asp Val Asn Lys Gln Glu Glu Lys Asn Glu Asp His Thr 
        35                  40                  45              


Pro Asn Tyr Ala Pro Ala Asn Glu Lys Asn Gly Asn Tyr Tyr Lys Asp 
    50                  55                  60                  


Ile Lys Gln Tyr Val Phe Thr Thr Gln Asn Pro Asn Gly Thr Glu Ser 
65                  70                  75                  80  


Glu Ile Ser Val Arg Ala Thr Thr Asp Leu Asn Phe Ala Leu Lys Asn 
                85                  90                  95      


Asp Lys Thr Val Asn Ala Thr Thr Tyr Glu Lys Ser Thr Ile Glu Glu 
            100                 105                 110         


Glu Thr Thr Thr Ser Glu Pro Ser His Lys Asn Ile Gln Ser Ile 
        115                 120                 125         


<210>  4854
<211>  265
<212>  PRT
<213>  Homo Sapiens

<400>  4854

Met Asn Phe Ile Leu Phe Ile Phe Ile Pro Gly Val Phe Ser Leu Lys 
1               5                   10                  15      


Ser Ser Thr Leu Lys Pro Thr Ile Glu Ala Leu Pro Asn Val Leu Pro 
            20                  25                  30          


Leu Asn Glu Asp Val Asn Lys Gln Glu Glu Lys Asn Glu Asp His Thr 
        35                  40                  45              


Pro Asn Tyr Ala Pro Ala Asn Glu Lys Asn Gly Asn Tyr Tyr Lys Asp 
    50                  55                  60                  


Ile Lys Gln Tyr Val Phe Thr Thr Gln Asn Pro Asn Gly Thr Glu Ser 
65                  70                  75                  80  


Glu Ile Ser Val Arg Ala Thr Thr Asp Leu Asn Phe Ala Leu Lys Asn 
                85                  90                  95      


Gly Ser Thr Pro Asn Val Pro Ala Phe Trp Thr Met Leu Ala Lys Ala 
            100                 105                 110         


Ile Asn Gly Thr Ala Val Val Met Asp Asp Lys Asp Gln Leu Phe His 
        115                 120                 125             


Pro Ile Pro Glu Ser Asp Val Asn Ala Thr Gln Gly Glu Asn Gln Pro 
    130                 135                 140                 


Asp Leu Glu Asp Leu Lys Ile Lys Ile Met Leu Gly Ile Ser Leu Met 
145                 150                 155                 160 


Thr Leu Leu Leu Phe Val Val Leu Leu Ala Phe Cys Ser Ala Thr Leu 
                165                 170                 175     


Tyr Lys Leu Arg His Leu Ser Tyr Lys Ser Cys Glu Ser Gln Tyr Ser 
            180                 185                 190         


Val Asn Pro Glu Leu Ala Thr Met Ser Tyr Phe His Pro Ser Glu Gly 
        195                 200                 205             


Val Ser Asp Thr Ser Phe Ser Lys Ser Ala Glu Ser Ser Thr Phe Leu 
    210                 215                 220                 


Gly Thr Thr Ser Ser Asp Met Arg Arg Ser Gly Thr Arg Thr Ser Glu 
225                 230                 235                 240 


Ser Lys Ile Met Thr Asp Ile Ile Ser Ile Gly Ser Asp Asn Glu Met 
                245                 250                 255     


His Glu Asn Asp Glu Ser Val Thr Arg 
            260                 265 


<210>  4855
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  4855

Met Ala Phe Pro Cys Phe Asp Glu Pro 
1               5                   


<210>  4856
<211>  129
<212>  PRT
<213>  Homo Sapiens

<400>  4856

Met Val Phe Leu Pro Leu Lys Trp Ser Leu Ala Thr Met Ser Phe Leu 
1               5                   10                  15      


Leu Ser Ser Leu Leu Ala Leu Leu Thr Val Ser Thr Pro Ser Trp Cys 
            20                  25                  30          


Gln Ser Thr Glu Ala Ser Pro Lys Arg Ser Asp Gly Thr Pro Phe Pro 
        35                  40                  45              


Trp Asn Lys Ile Arg Leu Pro Glu Tyr Val Ile Pro Val His Tyr Asp 
    50                  55                  60                  


Leu Leu Ile His Ala Asn Leu Thr Thr Leu Thr Phe Trp Gly Thr Thr 
65                  70                  75                  80  


Lys Val Glu Ile Thr Ala Ser Gln Pro Thr Ser Thr Ile Ile Leu His 
                85                  90                  95      


Ser His His Leu Gln Ile Ser Arg Ala Thr Leu Arg Lys Gly Ala Gly 
            100                 105                 110         


Glu Arg Leu Ser Glu Glu Pro Leu Gln Val Leu Glu His Pro Arg Gln 
        115                 120                 125             


Glu 
    


<210>  4857
<211>  948
<212>  PRT
<213>  Homo Sapiens

<400>  4857

Met Val Phe Leu Pro Leu Lys Trp Ser Leu Ala Thr Met Ser Phe Leu 
1               5                   10                  15      


Leu Ser Ser Leu Leu Ala Leu Leu Thr Val Ser Thr Pro Ser Trp Cys 
            20                  25                  30          


Gln Ser Thr Glu Ala Ser Pro Lys Arg Ser Asp Gly Thr Pro Phe Pro 
        35                  40                  45              


Trp Asn Lys Ile Arg Leu Pro Glu Tyr Val Ile Pro Val His Tyr Asp 
    50                  55                  60                  


Leu Leu Ile His Ala Asn Leu Thr Thr Leu Thr Phe Trp Gly Thr Thr 
65                  70                  75                  80  


Lys Val Glu Ile Thr Ala Ser Gln Pro Thr Ser Thr Ile Ile Leu His 
                85                  90                  95      


Ser His His Leu Gln Ile Ser Arg Ala Thr Leu Arg Lys Gly Ala Gly 
            100                 105                 110         


Glu Arg Leu Ser Glu Glu Pro Leu Gln Val Leu Glu His Pro Arg Gln 
        115                 120                 125             


Glu Gln Ile Ala Leu Leu Ala Pro Glu Pro Leu Leu Val Gly Leu Pro 
    130                 135                 140                 


Tyr Thr Val Val Ile His Tyr Ala Gly Asn Leu Ser Glu Thr Phe His 
145                 150                 155                 160 


Gly Phe Tyr Lys Ser Thr Tyr Arg Thr Lys Glu Gly Glu Leu Arg Ile 
                165                 170                 175     


Leu Ala Ser Thr Gln Phe Glu Pro Thr Ala Ala Arg Met Ala Phe Pro 
            180                 185                 190         


Cys Phe Asp Glu Pro Ala Phe Lys Ala Ser Phe Ser Ile Lys Ile Arg 
        195                 200                 205             


Arg Glu Pro Arg His Leu Ala Ile Ser Asn Met Pro Leu Val Lys Ser 
    210                 215                 220                 


Val Thr Val Ala Glu Gly Leu Ile Glu Asp His Phe Asp Val Thr Val 
225                 230                 235                 240 


Lys Met Ser Thr Tyr Leu Val Ala Phe Ile Ile Ser Asp Phe Glu Ser 
                245                 250                 255     


Val Ser Lys Ile Thr Lys Ser Gly Val Lys Val Ser Val Tyr Ala Val 
            260                 265                 270         


Pro Asp Lys Ile Asn Gln Ala Asp Tyr Ala Leu Asp Ala Ala Val Thr 
        275                 280                 285             


Leu Leu Glu Phe Tyr Glu Asp Tyr Phe Ser Ile Pro Tyr Pro Leu Pro 
    290                 295                 300                 


Lys Gln Asp Leu Ala Ala Ile Pro Asp Phe Gln Ser Gly Ala Met Glu 
305                 310                 315                 320 


Asn Trp Gly Leu Thr Thr Tyr Arg Glu Ser Ala Leu Leu Phe Asp Ala 
                325                 330                 335     


Glu Lys Ser Ser Ala Ser Ser Lys Leu Gly Ile Thr Met Thr Val Ala 
            340                 345                 350         


His Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr Met Glu Trp 
        355                 360                 365             


Trp Asn Asp Leu Trp Leu Asn Glu Gly Phe Ala Lys Phe Met Glu Phe 
    370                 375                 380                 


Val Ser Val Ser Val Thr His Pro Glu Leu Lys Val Gly Asp Tyr Phe 
385                 390                 395                 400 


Phe Gly Lys Cys Phe Asp Ala Met Glu Val Asp Ala Leu Asn Ser Ser 
                405                 410                 415     


His Pro Val Ser Thr Pro Val Glu Asn Pro Ala Gln Ile Arg Glu Met 
            420                 425                 430         


Phe Asp Asp Val Ser Tyr Asp Lys Gly Ala Cys Ile Leu Asn Met Leu 
        435                 440                 445             


Arg Glu Tyr Leu Ser Ala Asp Ala Phe Lys Ser Gly Ile Val Gln Tyr 
    450                 455                 460                 


Leu Gln Lys His Ser Tyr Lys Asn Thr Lys Asn Glu Asp Leu Trp Asp 
465                 470                 475                 480 


Ser Met Ala Ser Ile Cys Pro Thr Asp Gly Val Lys Gly Met Asp Gly 
                485                 490                 495     


Phe Cys Ser Arg Ser Gln His Ser Ser Ser Ser Ser His Trp His Gln 
            500                 505                 510         


Glu Gly Val Asp Val Lys Thr Met Met Asn Thr Trp Thr Leu Gln Lys 
        515                 520                 525             


Gly Phe Pro Leu Ile Thr Ile Thr Val Arg Gly Arg Asn Val His Met 
    530                 535                 540                 


Lys Gln Glu His Tyr Met Lys Gly Ser Asp Gly Ala Pro Asp Thr Gly 
545                 550                 555                 560 


Tyr Leu Trp His Val Pro Leu Thr Phe Ile Thr Ser Lys Ser Asp Met 
                565                 570                 575     


Val His Arg Phe Leu Leu Lys Thr Lys Thr Asp Val Leu Ile Leu Pro 
            580                 585                 590         


Glu Glu Val Glu Trp Ile Lys Phe Asn Val Gly Met Asn Gly Tyr Tyr 
        595                 600                 605             


Ile Val His Tyr Glu Asp Asp Gly Trp Asp Ser Leu Thr Gly Leu Leu 
    610                 615                 620                 


Lys Gly Thr His Thr Ala Val Ser Ser Asn Asp Arg Ala Ser Leu Ile 
625                 630                 635                 640 


Asn Asn Ala Phe Gln Leu Val Ser Ile Gly Lys Leu Ser Ile Glu Lys 
                645                 650                 655     


Ala Leu Asp Leu Ser Leu Tyr Leu Lys His Glu Thr Glu Ile Met Pro 
            660                 665                 670         


Val Phe Gln Gly Leu Asn Glu Leu Ile Pro Met Tyr Lys Leu Met Glu 
        675                 680                 685             


Lys Arg Asp Met Asn Glu Val Glu Thr Gln Phe Lys Ala Phe Leu Ile 
    690                 695                 700                 


Arg Leu Leu Arg Asp Leu Ile Asp Lys Gln Thr Trp Thr Asp Glu Gly 
705                 710                 715                 720 


Ser Val Ser Glu Arg Met Leu Arg Ser Gln Leu Leu Leu Leu Ala Cys 
                725                 730                 735     


Val His Asn Tyr Gln Pro Cys Val Gln Arg Ala Glu Gly Tyr Phe Arg 
            740                 745                 750         


Lys Trp Lys Glu Ser Asn Gly Asn Leu Ser Leu Pro Val Asp Val Thr 
        755                 760                 765             


Leu Ala Val Phe Ala Val Gly Ala Gln Ser Thr Glu Gly Trp Asp Phe 
    770                 775                 780                 


Leu Tyr Ser Lys Tyr Gln Phe Ser Leu Ser Ser Thr Glu Lys Ser Gln 
785                 790                 795                 800 


Ile Glu Phe Ala Leu Cys Arg Thr Gln Asn Lys Glu Lys Leu Gln Trp 
                805                 810                 815     


Leu Leu Asp Glu Ser Phe Lys Gly Asp Lys Ile Lys Thr Gln Glu Phe 
            820                 825                 830         


Pro Gln Ile Leu Thr Leu Ile Gly Arg Asn Pro Val Gly Tyr Pro Leu 
        835                 840                 845             


Ala Trp Gln Phe Leu Arg Lys Asn Trp Asn Lys Leu Val Gln Lys Phe 
    850                 855                 860                 


Glu Leu Gly Ser Ser Ser Ile Ala His Met Val Met Gly Thr Thr Asn 
865                 870                 875                 880 


Gln Phe Ser Thr Arg Thr Arg Leu Glu Glu Val Lys Gly Phe Phe Ser 
                885                 890                 895     


Ser Leu Lys Glu Asn Gly Ser Gln Leu Arg Cys Val Gln Gln Thr Ile 
            900                 905                 910         


Glu Thr Ile Glu Glu Asn Ile Gly Trp Met Asp Lys Asn Phe Asp Lys 
        915                 920                 925             


Ile Arg Val Trp Leu Gln Ser Glu Lys Leu Glu His Asp Pro Glu Ala 
    930                 935                 940                 


Asp Ala Thr Gly 
945             


<210>  4858
<211>  941
<212>  PRT
<213>  Homo Sapiens

<400>  4858

Met Val Phe Leu Pro Leu Lys Trp Ser Leu Ala Thr Met Ser Phe Leu 
1               5                   10                  15      


Leu Ser Ser Leu Leu Ala Leu Leu Thr Val Ser Thr Pro Ser Trp Cys 
            20                  25                  30          


Gln Ser Thr Glu Ala Ser Pro Lys Arg Ser Asp Gly Thr Pro Phe Pro 
        35                  40                  45              


Trp Asn Lys Ile Arg Leu Pro Glu Tyr Val Ile Pro Val His Tyr Asp 
    50                  55                  60                  


Leu Leu Ile His Ala Asn Leu Thr Thr Leu Thr Phe Trp Gly Thr Thr 
65                  70                  75                  80  


Lys Val Glu Ile Thr Ala Ser Gln Pro Thr Ser Thr Ile Ile Leu His 
                85                  90                  95      


Ser His His Leu Gln Ile Ser Arg Ala Thr Leu Arg Lys Gly Ala Gly 
            100                 105                 110         


Glu Arg Leu Ser Glu Glu Pro Leu Gln Val Leu Glu His Pro Arg Gln 
        115                 120                 125             


Glu Gln Ile Ala Leu Leu Ala Pro Glu Pro Leu Leu Val Gly Leu Pro 
    130                 135                 140                 


Tyr Thr Val Val Ile His Tyr Ala Gly Asn Leu Ser Glu Thr Phe His 
145                 150                 155                 160 


Gly Phe Tyr Lys Ser Thr Tyr Arg Thr Lys Glu Gly Glu Leu Arg Ile 
                165                 170                 175     


Leu Ala Ser Thr Gln Phe Glu Pro Thr Ala Ala Arg Met Ala Phe Pro 
            180                 185                 190         


Cys Phe Asp Glu Pro Ala Phe Lys Ala Ser Phe Ser Ile Lys Ile Arg 
        195                 200                 205             


Arg Glu Pro Arg His Leu Ala Ile Ser Asn Met Pro Leu Val Lys Ser 
    210                 215                 220                 


Val Thr Val Ala Glu Gly Leu Ile Glu Asp His Phe Asp Val Thr Val 
225                 230                 235                 240 


Lys Met Ser Thr Tyr Leu Val Ala Phe Ile Ile Ser Asp Phe Glu Ser 
                245                 250                 255     


Val Ser Lys Ile Thr Lys Ser Gly Val Lys Val Ser Val Tyr Ala Val 
            260                 265                 270         


Pro Asp Lys Ile Asn Gln Ala Asp Tyr Ala Leu Asp Ala Ala Val Thr 
        275                 280                 285             


Leu Leu Glu Phe Tyr Glu Asp Tyr Phe Ser Ile Pro Tyr Pro Leu Pro 
    290                 295                 300                 


Lys Gln Asp Leu Ala Ala Ile Pro Asp Phe Gln Ser Gly Ala Met Glu 
305                 310                 315                 320 


Asn Trp Gly Leu Thr Thr Tyr Arg Glu Ser Ala Leu Leu Phe Asp Ala 
                325                 330                 335     


Glu Lys Ser Ser Ala Ser Ser Lys Leu Gly Ile Thr Met Thr Val Ala 
            340                 345                 350         


His Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr Met Glu Trp 
        355                 360                 365             


Trp Asn Asp Leu Trp Leu Asn Glu Gly Phe Ala Lys Phe Met Glu Phe 
    370                 375                 380                 


Val Ser Val Ser Val Thr His Pro Glu Leu Lys Val Gly Asp Tyr Phe 
385                 390                 395                 400 


Phe Gly Lys Cys Phe Asp Ala Met Glu Val Asp Ala Leu Asn Ser Ser 
                405                 410                 415     


His Pro Val Ser Thr Pro Val Glu Asn Pro Ala Gln Ile Arg Glu Met 
            420                 425                 430         


Phe Asp Asp Val Ser Tyr Asp Lys Gly Ala Cys Ile Leu Asn Met Leu 
        435                 440                 445             


Arg Glu Tyr Leu Ser Ala Asp Ala Phe Lys Ser Gly Ile Val Gln Tyr 
    450                 455                 460                 


Leu Gln Lys His Ser Tyr Lys Asn Thr Lys Asn Glu Asp Leu Trp Asp 
465                 470                 475                 480 


Ser Met Ala Ser Ile Cys Pro Thr Asp Gly Val Lys Gly Met Asp Gly 
                485                 490                 495     


Phe Cys Ser Arg Ser Gln His Ser Ser Ser Ser Ser His Trp His Gln 
            500                 505                 510         


Glu Gly Val Asp Val Lys Thr Met Met Asn Thr Trp Thr Leu Gln Lys 
        515                 520                 525             


Gly Phe Pro Leu Ile Thr Ile Thr Val Arg Gly Arg Asn Val His Met 
    530                 535                 540                 


Lys Gln Glu His Tyr Met Lys Gly Ser Asp Gly Ala Pro Asp Thr Gly 
545                 550                 555                 560 


Tyr Leu Trp His Val Pro Leu Thr Phe Ile Thr Ser Lys Ser Asp Met 
                565                 570                 575     


Val His Arg Phe Leu Leu Lys Thr Lys Thr Asp Val Leu Ile Leu Pro 
            580                 585                 590         


Glu Glu Val Glu Trp Ile Lys Phe Asn Val Gly Met Asn Gly Tyr Tyr 
        595                 600                 605             


Ile Val His Tyr Glu Asp Asp Gly Trp Asp Ser Leu Thr Gly Leu Leu 
    610                 615                 620                 


Lys Gly Thr His Thr Ala Val Ser Ser Asn Asp Arg Ala Ser Leu Ile 
625                 630                 635                 640 


Asn Asn Ala Phe Gln Leu Val Ser Ile Gly Lys Leu Ser Ile Glu Lys 
                645                 650                 655     


Ala Leu Asp Leu Ser Leu Tyr Leu Lys His Glu Thr Glu Ile Met Pro 
            660                 665                 670         


Val Phe Gln Gly Leu Asn Glu Leu Ile Pro Met Tyr Lys Leu Met Glu 
        675                 680                 685             


Lys Arg Asp Met Asn Glu Val Glu Thr Gln Phe Lys Ala Phe Leu Ile 
    690                 695                 700                 


Arg Leu Leu Arg Asp Leu Ile Asp Lys Gln Thr Trp Thr Asp Glu Gly 
705                 710                 715                 720 


Ser Val Ser Glu Arg Met Leu Arg Ser Gln Leu Leu Leu Leu Ala Cys 
                725                 730                 735     


Val His Asn Tyr Gln Pro Cys Val Gln Arg Ala Glu Gly Tyr Phe Arg 
            740                 745                 750         


Lys Trp Lys Glu Ser Asn Gly Asn Leu Ser Leu Pro Val Asp Val Thr 
        755                 760                 765             


Leu Ala Val Phe Ala Val Gly Ala Gln Ser Thr Glu Gly Trp Asp Phe 
    770                 775                 780                 


Leu Tyr Ser Lys Tyr Gln Phe Ser Leu Ser Ser Thr Glu Lys Ser Gln 
785                 790                 795                 800 


Ile Glu Phe Ala Leu Cys Arg Thr Gln Asn Lys Glu Lys Leu Gln Trp 
                805                 810                 815     


Leu Leu Asp Glu Ser Phe Lys Gly Asp Lys Ile Lys Thr Gln Glu Phe 
            820                 825                 830         


Pro Gln Ile Leu Thr Leu Ile Gly Arg Asn Pro Val Gly Tyr Pro Leu 
        835                 840                 845             


Ala Trp Gln Phe Leu Arg Lys Asn Trp Asn Lys Leu Val Gln Lys Phe 
    850                 855                 860                 


Glu Leu Gly Ser Ser Ser Ile Ala His Met Val Met Gly Thr Thr Asn 
865                 870                 875                 880 


Gln Phe Ser Thr Arg Thr Arg Leu Glu Glu Val Lys Gly Phe Phe Ser 
                885                 890                 895     


Ser Leu Lys Glu Asn Gly Ser Gln Leu Arg Cys Val Gln Gln Thr Ile 
            900                 905                 910         


Glu Thr Ile Glu Glu Asn Ile Gly Trp Met Asp Lys Asn Phe Asp Lys 
        915                 920                 925             


Ile Arg Val Trp Leu Gln Ser Glu Lys Leu Glu Arg Met 
    930                 935                 940     


<210>  4859
<211>  144
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4859

Xaa Lys Gly Asp Lys Ile Lys Thr Gln Glu Phe Pro Gln Ile Leu Thr 
1               5                   10                  15      


Leu Ile Gly Arg Asn Pro Val Gly Tyr Pro Leu Ala Trp Gln Phe Leu 
            20                  25                  30          


Arg Lys Asn Trp Asn Lys Leu Val Gln Lys Phe Glu Leu Gly Ser Ser 
        35                  40                  45              


Ser Ile Ala His Met Val Met Gly Thr Thr Asn Gln Phe Ser Thr Arg 
    50                  55                  60                  


Thr Arg Leu Glu Glu Val Lys Gly Phe Phe Ser Ser Leu Lys Glu Asn 
65                  70                  75                  80  


Gly Ser Gln Leu Arg Cys Val Gln Gln Thr Ile Glu Thr Ile Glu Glu 
                85                  90                  95      


Asn Ile Gly Trp Met Asp Lys Asn Phe Asp Lys Ile Arg Val Trp Leu 
            100                 105                 110         


Gln Ser Glu Lys Leu Glu Arg Val Ala Leu Gln Arg Lys Pro Lys Cys 
        115                 120                 125             


Trp Val Pro Cys His Arg Arg Ile Lys Tyr Leu Ile Leu Leu Ile Leu 
    130                 135                 140                 


<210>  4860
<211>  960
<212>  PRT
<213>  Homo Sapiens

<400>  4860

Met Phe His Ser Ser Ala Met Val Asn Ser His Arg Lys Pro Met Phe 
1               5                   10                  15      


Asn Ile His Arg Gly Phe Tyr Cys Leu Thr Ala Ile Leu Pro Gln Ile 
            20                  25                  30          


Cys Ile Cys Ser Gln Phe Ser Val Pro Ser Ser Tyr His Phe Thr Glu 
        35                  40                  45              


Asp Pro Gly Ala Phe Pro Val Ala Thr Asn Gly Glu Arg Phe Pro Trp 
    50                  55                  60                  


Gln Glu Leu Arg Leu Pro Ser Val Val Ile Pro Leu His Tyr Asp Leu 
65                  70                  75                  80  


Phe Val His Pro Asn Leu Thr Ser Leu Asp Phe Val Ala Ser Glu Lys 
                85                  90                  95      


Ile Glu Val Leu Val Ser Asn Ala Thr Gln Phe Ile Ile Leu His Ser 
            100                 105                 110         


Lys Asp Leu Glu Ile Thr Asn Ala Thr Leu Gln Ser Glu Glu Asp Ser 
        115                 120                 125             


Arg Tyr Met Lys Pro Gly Lys Glu Leu Lys Val Leu Ser Tyr Pro Ala 
    130                 135                 140                 


His Glu Gln Ile Ala Leu Leu Val Pro Glu Lys Leu Thr Pro His Leu 
145                 150                 155                 160 


Lys Tyr Tyr Val Ala Met Asp Phe Gln Ala Lys Leu Gly Asp Gly Phe 
                165                 170                 175     


Glu Gly Phe Tyr Lys Ser Thr Tyr Arg Thr Leu Gly Gly Glu Thr Arg 
            180                 185                 190         


Ile Leu Ala Val Thr Asp Phe Glu Pro Thr Gln Ala Arg Met Ala Phe 
        195                 200                 205             


Pro Cys Phe Asp Glu Pro Leu Phe Lys Ala Asn Phe Ser Ile Lys Ile 
    210                 215                 220                 


Arg Arg Glu Ser Arg His Ile Ala Leu Ser Asn Met Pro Lys Val Lys 
225                 230                 235                 240 


Thr Ile Glu Leu Glu Gly Gly Leu Leu Glu Asp His Phe Glu Thr Thr 
                245                 250                 255     


Val Lys Met Ser Thr Tyr Leu Val Ala Tyr Ile Val Cys Asp Phe His 
            260                 265                 270         


Ser Leu Ser Gly Phe Thr Ser Ser Gly Val Lys Val Ser Ile Tyr Ala 
        275                 280                 285             


Ser Pro Asp Lys Arg Asn Gln Thr His Tyr Ala Leu Gln Ala Ser Leu 
    290                 295                 300                 


Lys Leu Leu Asp Phe Tyr Glu Lys Tyr Phe Asp Ile Tyr Tyr Pro Leu 
305                 310                 315                 320 


Ser Lys Leu Asp Leu Ile Ala Ile Pro Asp Phe Ala Pro Gly Ala Met 
                325                 330                 335     


Glu Asn Trp Gly Leu Ile Thr Tyr Arg Glu Thr Ser Leu Leu Phe Asp 
            340                 345                 350         


Pro Lys Thr Ser Ser Ala Ser Asp Lys Leu Trp Val Thr Arg Val Ile 
        355                 360                 365             


Ala His Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr Met Glu 
    370                 375                 380                 


Trp Trp Asn Asp Ile Trp Leu Lys Glu Gly Phe Ala Lys Tyr Met Glu 
385                 390                 395                 400 


Leu Ile Ala Val Asn Ala Thr Tyr Pro Glu Leu Gln Phe Asp Asp Tyr 
                405                 410                 415     


Phe Leu Asn Val Cys Phe Glu Val Ile Thr Lys Asp Ser Leu Asn Ser 
            420                 425                 430         


Ser Arg Pro Ile Ser Lys Pro Ala Glu Thr Pro Thr Gln Ile Gln Glu 
        435                 440                 445             


Met Phe Asp Glu Val Ser Tyr Asn Lys Gly Ala Cys Ile Leu Asn Met 
    450                 455                 460                 


Leu Lys Asp Phe Leu Gly Glu Glu Lys Phe Gln Lys Gly Ile Ile Gln 
465                 470                 475                 480 


Tyr Leu Lys Lys Phe Ser Tyr Arg Asn Ala Lys Asn Asp Asp Leu Trp 
                485                 490                 495     


Ser Ser Leu Ser Asn Ser Cys Leu Glu Ser Asp Phe Thr Ser Gly Gly 
            500                 505                 510         


Val Cys His Ser Asp Pro Lys Met Thr Ser Asn Met Leu Ala Phe Leu 
        515                 520                 525             


Gly Glu Asn Ala Glu Val Lys Glu Met Met Thr Thr Trp Thr Leu Gln 
    530                 535                 540                 


Lys Gly Ile Pro Leu Leu Val Val Lys Gln Asp Gly Cys Ser Leu Arg 
545                 550                 555                 560 


Leu Gln Gln Glu Arg Phe Leu Gln Gly Val Phe Gln Glu Asp Pro Glu 
                565                 570                 575     


Trp Arg Ala Leu Gln Glu Arg Tyr Leu Trp His Ile Pro Leu Thr Tyr 
            580                 585                 590         


Ser Thr Ser Ser Ser Asn Val Ile His Arg His Ile Leu Lys Ser Lys 
        595                 600                 605             


Thr Asp Thr Leu Asp Leu Pro Glu Lys Thr Ser Trp Val Lys Phe Asn 
    610                 615                 620                 


Val Asp Ser Asn Gly Tyr Tyr Ile Val His Tyr Glu Gly His Gly Trp 
625                 630                 635                 640 


Asp Gln Leu Ile Thr Gln Leu Asn Gln Asn His Thr Leu Leu Arg Pro 
                645                 650                 655     


Lys Asp Arg Val Gly Leu Ile His Asp Val Phe Gln Leu Val Gly Ala 
            660                 665                 670         


Gly Arg Leu Thr Leu Asp Lys Ala Leu Asp Met Thr Tyr Tyr Leu Gln 
        675                 680                 685             


His Glu Thr Ser Ser Pro Ala Leu Leu Glu Gly Leu Ser Tyr Leu Glu 
    690                 695                 700                 


Ser Phe Tyr His Met Met Asp Arg Arg Asn Ile Ser Asp Ile Ser Glu 
705                 710                 715                 720 


Asn Leu Lys Arg Tyr Leu Leu Gln Tyr Phe Lys Pro Val Ile Asp Arg 
                725                 730                 735     


Gln Ser Trp Ser Asp Lys Gly Ser Val Trp Asp Arg Met Leu Arg Ser 
            740                 745                 750         


Ala Leu Leu Lys Leu Ala Cys Asp Leu Asn His Ala Pro Cys Ile Gln 
        755                 760                 765             


Lys Ala Ala Glu Leu Phe Ser Gln Trp Met Glu Ser Ser Gly Lys Leu 
    770                 775                 780                 


Asn Ile Pro Thr Asp Val Leu Lys Ile Val Tyr Ser Val Gly Ala Gln 
785                 790                 795                 800 


Thr Thr Ala Gly Trp Asn Tyr Leu Leu Glu Gln Tyr Glu Leu Ser Met 
                805                 810                 815     


Ser Ser Ala Glu Gln Asn Lys Ile Leu Tyr Ala Leu Ser Thr Ser Lys 
            820                 825                 830         


His Gln Glu Lys Leu Leu Lys Leu Ile Glu Leu Gly Met Glu Gly Lys 
        835                 840                 845             


Val Ile Lys Thr Gln Asn Leu Ala Ala Leu Leu His Ala Ile Ala Arg 
    850                 855                 860                 


Arg Pro Lys Gly Gln Gln Leu Ala Trp Asp Phe Val Arg Glu Asn Trp 
865                 870                 875                 880 


Thr His Leu Leu Lys Lys Phe Asp Leu Gly Ser Tyr Asp Ile Arg Met 
                885                 890                 895     


Ile Ile Ser Gly Thr Thr Ala His Phe Ser Ser Lys Asp Lys Leu Gln 
            900                 905                 910         


Glu Val Lys Leu Phe Phe Glu Ser Leu Glu Ala Gln Gly Ser His Leu 
        915                 920                 925             


Asp Ile Phe Gln Thr Val Leu Glu Thr Ile Thr Lys Asn Ile Lys Trp 
    930                 935                 940                 


Leu Glu Lys Asn Leu Pro Thr Leu Arg Thr Trp Leu Met Val Asn Thr 
945                 950                 955                 960 


<210>  4861
<211>  350
<212>  PRT
<213>  Homo Sapiens

<400>  4861

Met Phe His Ser Ser Ala Met Val Asn Ser His Arg Lys Pro Met Phe 
1               5                   10                  15      


Asn Ile His Arg Gly Phe Tyr Cys Leu Thr Ala Ile Leu Pro Gln Ile 
            20                  25                  30          


Cys Ile Cys Ser Gln Phe Ser Val Pro Ser Ser Tyr His Phe Thr Glu 
        35                  40                  45              


Asp Pro Gly Ala Phe Pro Val Ala Thr Asn Gly Glu Arg Phe Pro Trp 
    50                  55                  60                  


Gln Glu Leu Arg Leu Pro Ser Val Val Ile Pro Leu His Tyr Asp Leu 
65                  70                  75                  80  


Phe Val His Pro Asn Leu Thr Ser Leu Asp Phe Val Ala Ser Glu Lys 
                85                  90                  95      


Ile Glu Val Leu Val Ser Asn Ala Thr Gln Phe Ile Ile Leu His Ser 
            100                 105                 110         


Lys Asp Leu Glu Ile Thr Asn Ala Thr Leu Gln Ser Glu Glu Asp Ser 
        115                 120                 125             


Arg Tyr Met Lys Pro Gly Lys Glu Leu Lys Val Leu Ser Tyr Pro Ala 
    130                 135                 140                 


His Glu Gln Ile Ala Leu Leu Val Pro Glu Lys Leu Thr Pro His Leu 
145                 150                 155                 160 


Lys Tyr Tyr Val Ala Met Asp Phe Gln Ala Lys Leu Gly Asp Gly Phe 
                165                 170                 175     


Glu Gly Phe Tyr Lys Ser Thr Tyr Arg Thr Leu Gly Gly Glu Thr Arg 
            180                 185                 190         


Ile Leu Ala Val Thr Asp Phe Glu Pro Thr Gln Ala Arg Met Ala Phe 
        195                 200                 205             


Pro Cys Phe Asp Glu Pro Leu Phe Lys Ala Asn Phe Ser Ile Lys Ile 
    210                 215                 220                 


Arg Arg Glu Ser Arg His Ile Ala Leu Ser Asn Met Pro Lys Val Lys 
225                 230                 235                 240 


Thr Ile Glu Leu Glu Gly Gly Leu Leu Glu Asp His Phe Glu Thr Thr 
                245                 250                 255     


Val Lys Met Ser Thr Tyr Leu Val Ala Tyr Ile Val Cys Asp Phe His 
            260                 265                 270         


Ser Leu Ser Gly Phe Thr Ser Ser Gly Val Lys Val Ser Ile Tyr Ala 
        275                 280                 285             


Ser Pro Asp Lys Arg Asn Gln Thr His Tyr Ala Leu Gln Ala Ser Leu 
    290                 295                 300                 


Lys Leu Leu Asp Phe Tyr Glu Lys Tyr Phe Asp Ile Tyr Tyr Pro Leu 
305                 310                 315                 320 


Ser Lys Leu Gly Met Phe Lys Phe His Ile Ile Val Phe Ile Phe Ala 
                325                 330                 335     


His Lys Thr Cys Phe Asp Leu Phe Pro Leu Ser Leu Ser Met 
            340                 345                 350 


<210>  4862
<211>  694
<212>  PRT
<213>  Homo Sapiens

<400>  4862

Met Phe His Ser Ser Ala Met Val Asn Ser His Arg Lys Pro Met Phe 
1               5                   10                  15      


Asn Ile His Arg Gly Phe Tyr Cys Leu Thr Ala Ile Leu Pro Gln Ile 
            20                  25                  30          


Cys Ile Cys Ser Gln Phe Ser Val Pro Ser Ser Tyr His Phe Thr Glu 
        35                  40                  45              


Asp Pro Gly Ala Phe Pro Val Ala Thr Asn Gly Glu Arg Phe Pro Trp 
    50                  55                  60                  


Gln Glu Leu Arg Leu Pro Ser Val Val Ile Pro Leu His Tyr Asp Leu 
65                  70                  75                  80  


Phe Val His Pro Asn Leu Thr Ser Leu Asp Phe Val Ala Ser Glu Lys 
                85                  90                  95      


Ile Glu Val Leu Val Ser Asn Ala Thr Gln Phe Ile Ile Leu His Ser 
            100                 105                 110         


Lys Asp Leu Glu Ile Thr Asn Ala Thr Leu Gln Ser Glu Glu Asp Ser 
        115                 120                 125             


Arg Tyr Met Lys Pro Gly Lys Glu Leu Lys Val Leu Ser Tyr Pro Ala 
    130                 135                 140                 


His Glu Gln Ile Ala Leu Leu Val Pro Glu Lys Leu Thr Pro His Leu 
145                 150                 155                 160 


Lys Tyr Tyr Val Ala Met Asp Phe Gln Ala Lys Leu Gly Asp Gly Phe 
                165                 170                 175     


Glu Gly Phe Tyr Lys Ser Thr Tyr Arg Thr Leu Gly Gly Glu Thr Arg 
            180                 185                 190         


Ile Leu Ala Val Thr Asp Phe Glu Pro Thr Gln Ala Arg Met Ala Phe 
        195                 200                 205             


Pro Cys Phe Asp Glu Pro Leu Phe Lys Ala Asn Phe Ser Ile Lys Ile 
    210                 215                 220                 


Arg Arg Glu Ser Arg His Ile Ala Leu Ser Asn Met Pro Lys Val Lys 
225                 230                 235                 240 


Thr Ile Glu Leu Glu Gly Gly Leu Leu Glu Asp His Phe Glu Thr Thr 
                245                 250                 255     


Val Lys Met Ser Thr Tyr Leu Val Ala Tyr Ile Val Cys Asp Phe His 
            260                 265                 270         


Ser Leu Ser Gly Phe Thr Ser Ser Gly Val Lys Val Ser Ile Tyr Ala 
        275                 280                 285             


Ser Pro Asp Lys Arg Asn Gln Thr His Tyr Ala Leu Gln Ala Ser Leu 
    290                 295                 300                 


Lys Leu Leu Asp Phe Tyr Glu Lys Tyr Phe Asp Ile Tyr Tyr Pro Leu 
305                 310                 315                 320 


Ser Lys Leu Asp Leu Ile Ala Ile Pro Asp Phe Ala Pro Gly Ala Met 
                325                 330                 335     


Glu Asn Trp Gly Leu Ile Thr Tyr Arg Glu Thr Ser Leu Leu Phe Asp 
            340                 345                 350         


Pro Lys Thr Ser Ser Ala Ser Asp Lys Leu Trp Val Thr Arg Val Ile 
        355                 360                 365             


Ala His Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr Met Glu 
    370                 375                 380                 


Trp Trp Asn Asp Ile Trp Leu Lys Glu Gly Phe Ala Lys Tyr Met Glu 
385                 390                 395                 400 


Leu Ile Ala Val Asn Ala Thr Tyr Pro Glu Leu Gln Phe Asp Asp Tyr 
                405                 410                 415     


Phe Leu Asn Val Cys Phe Glu Val Ile Thr Lys Asp Ser Leu Asn Ser 
            420                 425                 430         


Ser Arg Pro Ile Ser Lys Pro Ala Glu Thr Pro Thr Gln Ile Gln Glu 
        435                 440                 445             


Met Phe Asp Glu Val Ser Tyr Asn Lys Gly Ala Cys Ile Leu Asn Met 
    450                 455                 460                 


Leu Lys Asp Phe Leu Gly Glu Glu Lys Phe Gln Lys Gly Ile Ile Gln 
465                 470                 475                 480 


Tyr Leu Lys Lys Phe Ser Tyr Arg Asn Ala Lys Asn Asp Asp Leu Trp 
                485                 490                 495     


Ser Ser Leu Ser Asn Ser Cys Leu Glu Ser Asp Phe Thr Ser Gly Gly 
            500                 505                 510         


Val Cys His Ser Asp Pro Lys Met Thr Ser Asn Met Leu Ala Phe Leu 
        515                 520                 525             


Gly Glu Asn Ala Glu Val Lys Glu Met Met Thr Thr Trp Thr Leu Gln 
    530                 535                 540                 


Lys Gly Ile Pro Leu Leu Val Val Lys Gln Asp Gly Cys Ser Leu Arg 
545                 550                 555                 560 


Leu Gln Gln Glu Arg Phe Leu Gln Gly Val Phe Gln Glu Asp Pro Glu 
                565                 570                 575     


Trp Arg Ala Leu Gln Glu Arg Tyr Leu Trp His Ile Pro Leu Thr Tyr 
            580                 585                 590         


Ser Thr Ser Ser Ser Asn Val Ile His Arg His Ile Leu Lys Ser Lys 
        595                 600                 605             


Thr Asp Thr Leu Asp Leu Pro Glu Lys Thr Ser Trp Val Lys Phe Asn 
    610                 615                 620                 


Val Asp Ser Asn Gly Tyr Tyr Ile Val His Tyr Glu Gly His Gly Trp 
625                 630                 635                 640 


Asp Gln Leu Ile Thr Gln Leu Asn Gln Asn His Thr Leu Leu Arg Pro 
                645                 650                 655     


Lys Asp Arg Val Gly Leu Ile His Asp Val Phe Gln Leu Val Gly Ala 
            660                 665                 670         


Gly Arg Leu Thr Leu Asp Lys Ala Leu Asp Met Thr Tyr Tyr Leu Gln 
        675                 680                 685             


His Glu Thr Ser Ser Pro 
    690                 


<210>  4863
<211>  532
<212>  PRT
<213>  Homo Sapiens

<400>  4863

Met Phe His Ser Ser Ala Met Val Asn Ser His Arg Lys Pro Met Phe 
1               5                   10                  15      


Asn Ile His Arg Gly Phe Tyr Cys Leu Thr Ala Ile Leu Pro Gln Ile 
            20                  25                  30          


Cys Ile Cys Ser Gln Phe Ser Val Pro Ser Ser Tyr His Phe Thr Glu 
        35                  40                  45              


Asp Pro Gly Ala Phe Pro Val Ala Thr Asn Gly Glu Arg Phe Pro Trp 
    50                  55                  60                  


Gln Glu Leu Arg Leu Pro Ser Val Val Ile Pro Leu His Tyr Asp Leu 
65                  70                  75                  80  


Phe Val His Pro Asn Leu Thr Ser Leu Asp Phe Val Ala Ser Glu Lys 
                85                  90                  95      


Ile Glu Val Leu Val Ser Asn Ala Thr Gln Phe Ile Ile Leu His Ser 
            100                 105                 110         


Lys Asp Leu Glu Ile Thr Asn Ala Thr Leu Gln Ser Glu Glu Asp Ser 
        115                 120                 125             


Arg Tyr Met Lys Pro Gly Lys Glu Leu Lys Val Leu Ser Tyr Pro Ala 
    130                 135                 140                 


His Glu Gln Ile Ala Leu Leu Val Pro Glu Lys Leu Thr Pro His Leu 
145                 150                 155                 160 


Lys Tyr Tyr Val Ala Met Asp Phe Gln Ala Lys Leu Gly Asp Gly Phe 
                165                 170                 175     


Glu Gly Phe Tyr Lys Ser Thr Tyr Arg Thr Leu Gly Gly Glu Thr Arg 
            180                 185                 190         


Ile Leu Ala Val Thr Asp Phe Glu Pro Thr Gln Ala Arg Met Ala Phe 
        195                 200                 205             


Pro Cys Phe Asp Glu Pro Leu Phe Lys Ala Asn Phe Ser Ile Lys Ile 
    210                 215                 220                 


Arg Arg Glu Ser Arg His Ile Ala Leu Ser Asn Met Pro Lys Val Lys 
225                 230                 235                 240 


Thr Ile Glu Leu Glu Gly Gly Leu Leu Glu Asp His Phe Glu Thr Thr 
                245                 250                 255     


Val Lys Met Ser Thr Tyr Leu Val Ala Tyr Ile Val Cys Asp Phe His 
            260                 265                 270         


Ser Leu Ser Gly Phe Thr Ser Ser Gly Val Lys Val Ser Ile Tyr Ala 
        275                 280                 285             


Ser Pro Asp Lys Arg Asn Gln Thr His Tyr Ala Leu Gln Ala Ser Leu 
    290                 295                 300                 


Lys Leu Leu Asp Phe Tyr Glu Lys Tyr Phe Asp Ile Tyr Tyr Pro Leu 
305                 310                 315                 320 


Ser Lys Leu Asp Leu Ile Ala Ile Pro Asp Phe Ala Pro Gly Ala Met 
                325                 330                 335     


Glu Asn Trp Gly Leu Ile Thr Tyr Arg Glu Thr Ser Leu Leu Phe Asp 
            340                 345                 350         


Pro Lys Thr Ser Ser Ala Ser Asp Lys Leu Trp Val Thr Arg Val Ile 
        355                 360                 365             


Ala His Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr Met Glu 
    370                 375                 380                 


Trp Trp Asn Asp Ile Trp Leu Lys Glu Gly Phe Ala Lys Tyr Met Glu 
385                 390                 395                 400 


Leu Ile Ala Val Asn Ala Thr Tyr Pro Glu Leu Gln Phe Asp Asp Tyr 
                405                 410                 415     


Phe Leu Asn Val Cys Phe Glu Val Ile Thr Lys Asp Ser Leu Asn Ser 
            420                 425                 430         


Ser Arg Pro Ile Ser Lys Pro Ala Glu Thr Pro Thr Gln Ile Gln Glu 
        435                 440                 445             


Met Phe Asp Glu Val Ser Tyr Asn Lys Gly Ala Cys Ile Leu Asn Met 
    450                 455                 460                 


Leu Lys Asp Phe Leu Gly Glu Glu Lys Phe Gln Lys Gly Ile Ile Gln 
465                 470                 475                 480 


Tyr Leu Lys Lys Phe Ser Tyr Arg Asn Ala Lys Asn Asp Asp Leu Trp 
                485                 490                 495     


Ser Ser Leu Ser Asn Ser Cys Leu Glu Ser Asp Phe Thr Ser Gly Gly 
            500                 505                 510         


Val Cys His Ser Asp Pro Lys Met Thr Ser Asn Met Val Arg Ile Lys 
        515                 520                 525             


Arg Val Thr Glu 
    530         


<210>  4864
<211>  915
<212>  PRT
<213>  Homo Sapiens

<400>  4864

Met Phe His Ser Ser Ala Met Val Asn Ser His Arg Lys Pro Met Phe 
1               5                   10                  15      


Asn Ile His Arg Gly Phe Tyr Cys Leu Thr Ala Ile Leu Pro Gln Ile 
            20                  25                  30          


Cys Ile Cys Ser Gln Phe Ser Val Pro Ser Ser Tyr His Phe Thr Glu 
        35                  40                  45              


Asp Pro Gly Ala Phe Pro Val Ala Thr Asn Gly Glu Arg Phe Pro Trp 
    50                  55                  60                  


Gln Glu Leu Arg Leu Pro Ser Val Val Ile Pro Leu His Tyr Asp Leu 
65                  70                  75                  80  


Phe Val His Pro Asn Leu Thr Ser Leu Asp Phe Val Ala Ser Glu Lys 
                85                  90                  95      


Ile Glu Val Leu Val Ser Asn Ala Thr Gln Phe Ile Ile Leu His Ser 
            100                 105                 110         


Lys Asp Leu Glu Ile Thr Asn Ala Thr Leu Gln Ser Glu Glu Asp Ser 
        115                 120                 125             


Arg Tyr Met Lys Pro Gly Lys Glu Leu Lys Val Leu Ser Tyr Pro Ala 
    130                 135                 140                 


His Glu Gln Ile Ala Leu Leu Val Pro Glu Lys Leu Thr Pro His Leu 
145                 150                 155                 160 


Lys Tyr Tyr Val Ala Met Asp Phe Gln Ala Lys Leu Gly Asp Gly Phe 
                165                 170                 175     


Glu Gly Phe Tyr Lys Ser Thr Tyr Arg Thr Leu Gly Gly Glu Thr Arg 
            180                 185                 190         


Ile Leu Ala Val Thr Asp Phe Glu Pro Thr Gln Ala Arg Met Ala Phe 
        195                 200                 205             


Pro Cys Phe Asp Glu Pro Leu Phe Lys Ala Asn Phe Ser Ile Lys Ile 
    210                 215                 220                 


Arg Arg Glu Ser Arg His Ile Ala Leu Ser Asn Met Pro Lys Val Ser 
225                 230                 235                 240 


Ile Tyr Ala Ser Pro Asp Lys Arg Asn Gln Thr His Tyr Ala Leu Gln 
                245                 250                 255     


Ala Ser Leu Lys Leu Leu Asp Phe Tyr Glu Lys Tyr Phe Asp Ile Tyr 
            260                 265                 270         


Tyr Pro Leu Ser Lys Leu Asp Leu Ile Ala Ile Pro Asp Phe Ala Pro 
        275                 280                 285             


Gly Ala Met Glu Asn Trp Gly Leu Ile Thr Tyr Arg Glu Thr Ser Leu 
    290                 295                 300                 


Leu Phe Asp Pro Lys Thr Ser Ser Ala Ser Asp Lys Leu Trp Val Thr 
305                 310                 315                 320 


Arg Val Ile Ala His Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val 
                325                 330                 335     


Thr Met Glu Trp Trp Asn Asp Ile Trp Leu Lys Glu Gly Phe Ala Lys 
            340                 345                 350         


Tyr Met Glu Leu Ile Ala Val Asn Ala Thr Tyr Pro Glu Leu Gln Phe 
        355                 360                 365             


Asp Asp Tyr Phe Leu Asn Val Cys Phe Glu Val Ile Thr Lys Asp Ser 
    370                 375                 380                 


Leu Asn Ser Ser Arg Pro Ile Ser Lys Pro Ala Glu Thr Pro Thr Gln 
385                 390                 395                 400 


Ile Gln Glu Met Phe Asp Glu Val Ser Tyr Asn Lys Gly Ala Cys Ile 
                405                 410                 415     


Leu Asn Met Leu Lys Asp Phe Leu Gly Glu Glu Lys Phe Gln Lys Gly 
            420                 425                 430         


Ile Ile Gln Tyr Leu Lys Lys Phe Ser Tyr Arg Asn Ala Lys Asn Asp 
        435                 440                 445             


Asp Leu Trp Ser Ser Leu Ser Asn Ser Cys Leu Glu Ser Asp Phe Thr 
    450                 455                 460                 


Ser Gly Gly Val Cys His Ser Asp Pro Lys Met Thr Ser Asn Met Leu 
465                 470                 475                 480 


Ala Phe Leu Gly Glu Asn Ala Glu Val Lys Glu Met Met Thr Thr Trp 
                485                 490                 495     


Thr Leu Gln Lys Gly Ile Pro Leu Leu Val Val Lys Gln Asp Gly Cys 
            500                 505                 510         


Ser Leu Arg Leu Gln Gln Glu Arg Phe Leu Gln Gly Val Phe Gln Glu 
        515                 520                 525             


Asp Pro Glu Trp Arg Ala Leu Gln Glu Arg Tyr Leu Trp His Ile Pro 
    530                 535                 540                 


Leu Thr Tyr Ser Thr Ser Ser Ser Asn Val Ile His Arg His Ile Leu 
545                 550                 555                 560 


Lys Ser Lys Thr Asp Thr Leu Asp Leu Pro Glu Lys Thr Ser Trp Val 
                565                 570                 575     


Lys Phe Asn Val Asp Ser Asn Gly Tyr Tyr Ile Val His Tyr Glu Gly 
            580                 585                 590         


His Gly Trp Asp Gln Leu Ile Thr Gln Leu Asn Gln Asn His Thr Leu 
        595                 600                 605             


Leu Arg Pro Lys Asp Arg Val Gly Leu Ile His Asp Val Phe Gln Leu 
    610                 615                 620                 


Val Gly Ala Gly Arg Leu Thr Leu Asp Lys Ala Leu Asp Met Thr Tyr 
625                 630                 635                 640 


Tyr Leu Gln His Glu Thr Ser Ser Pro Ala Leu Leu Glu Gly Leu Ser 
                645                 650                 655     


Tyr Leu Glu Ser Phe Tyr His Met Met Asp Arg Arg Asn Ile Ser Asp 
            660                 665                 670         


Ile Ser Glu Asn Leu Lys Arg Tyr Leu Leu Gln Tyr Phe Lys Pro Val 
        675                 680                 685             


Ile Asp Arg Gln Ser Trp Ser Asp Lys Gly Ser Val Trp Asp Arg Met 
    690                 695                 700                 


Leu Arg Ser Ala Leu Leu Lys Leu Ala Cys Asp Leu Asn His Ala Pro 
705                 710                 715                 720 


Cys Ile Gln Lys Ala Ala Glu Leu Phe Ser Gln Trp Met Glu Ser Ser 
                725                 730                 735     


Gly Lys Leu Asn Ile Pro Thr Asp Val Leu Lys Ile Val Tyr Ser Val 
            740                 745                 750         


Gly Ala Gln Thr Thr Ala Gly Trp Asn Tyr Leu Leu Glu Gln Tyr Glu 
        755                 760                 765             


Leu Ser Met Ser Ser Ala Glu Gln Asn Lys Ile Leu Tyr Ala Leu Ser 
    770                 775                 780                 


Thr Ser Lys His Gln Glu Lys Leu Leu Lys Leu Ile Glu Leu Gly Met 
785                 790                 795                 800 


Glu Gly Lys Val Ile Lys Thr Gln Asn Leu Ala Ala Leu Leu His Ala 
                805                 810                 815     


Ile Ala Arg Arg Pro Lys Gly Gln Gln Leu Ala Trp Asp Phe Val Arg 
            820                 825                 830         


Glu Asn Trp Thr His Leu Leu Lys Lys Phe Asp Leu Gly Ser Tyr Asp 
        835                 840                 845             


Ile Arg Met Ile Ile Ser Gly Thr Thr Ala His Phe Ser Ser Lys Asp 
    850                 855                 860                 


Lys Leu Gln Glu Val Lys Leu Phe Phe Glu Ser Leu Glu Ala Gln Gly 
865                 870                 875                 880 


Ser His Leu Asp Ile Phe Gln Thr Val Leu Glu Thr Ile Thr Lys Asn 
                885                 890                 895     


Ile Lys Trp Leu Glu Lys Asn Leu Pro Thr Leu Arg Thr Trp Leu Met 
            900                 905                 910         


Val Asn Thr 
        915 


<210>  4865
<211>  29
<212>  PRT
<213>  Homo Sapiens

<400>  4865

Met Leu His Arg Val Asp Gly Leu Val Ser Gln Gly Gln Asp Pro Ser 
1               5                   10                  15      


Gly Arg Ile Leu Ala Val Thr Asp Phe Glu Pro Thr Gln 
            20                  25                  


<210>  4866
<211>  79
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4866

Xaa Gly Lys Val Ile Lys Thr Gln Asn Leu Ala Ala Leu Leu His Ala 
1               5                   10                  15      


Ile Ala Arg Arg Pro Lys Gly Gln Gln Leu Ala Trp Asp Phe Val Arg 
            20                  25                  30          


Glu Asn Trp Thr His Leu Leu Lys Lys Phe Asp Leu Gly Ser Tyr Asp 
        35                  40                  45              


Ile Arg Met Ile Ile Ser Gly Thr Thr Ala His Phe Ser Ser Lys Asp 
    50                  55                  60                  


Lys Leu Gln Glu Val Cys Asp Phe Leu Phe Leu Thr Ile Ser Lys 
65                  70                  75                  


<210>  4867
<211>  163
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4867

Xaa Gln Thr His Tyr Ala Leu Gln Ala Ser Leu Lys Leu Leu Asp Phe 
1               5                   10                  15      


Tyr Glu Lys Tyr Phe Asp Ile Tyr Tyr Pro Leu Ser Lys Leu Asp Leu 
            20                  25                  30          


Ile Ala Ile Pro Asp Phe Ala Pro Gly Ala Met Glu Asn Trp Gly Leu 
        35                  40                  45              


Ile Thr Tyr Arg Glu Thr Ser Leu Leu Phe Asp Pro Lys Thr Ser Ser 
    50                  55                  60                  


Ala Ser Asp Lys Leu Trp Val Thr Arg Val Ile Ala His Glu Leu Ala 
65                  70                  75                  80  


His Gln Trp Phe Gly Asn Leu Val Thr Met Glu Trp Trp Asn Asp Ile 
                85                  90                  95      


Trp Leu Lys Glu Gly Phe Ala Lys Tyr Met Glu Leu Ile Ala Val Asn 
            100                 105                 110         


Ala Thr Tyr Pro Glu Leu Gln Phe Gly Ala Cys Ile Leu Asn Met Leu 
        115                 120                 125             


Lys Asp Phe Leu Gly Glu Glu Lys Phe Gln Lys Gly Ile Ile Gln Tyr 
    130                 135                 140                 


Leu Lys Lys Phe Ser Tyr Arg Asn Ala Lys Asn Asp Asp Leu Trp Ser 
145                 150                 155                 160 


Ser Leu Ser 
            


<210>  4868
<211>  649
<212>  PRT
<213>  Homo Sapiens

<400>  4868

Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val Cys Val Thr His 
1               5                   10                  15      


Cys Asn Phe Leu Asn Gly Glu Pro Arg Glu Phe Ala His Glu Ala Glu 
            20                  25                  30          


Cys Phe Ser Cys His Pro Glu Cys Gln Pro Met Glu Gly Thr Ala Thr 
        35                  40                  45              


Cys Asn Gly Ser Gly Ser Asp Thr Cys Ala Gln Cys Ala His Phe Arg 
    50                  55                  60                  


Asp Gly Pro His Cys Val Ser Ser Cys Pro His Gly Val Leu Gly Ala 
65                  70                  75                  80  


Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Val Gln Asn Glu Cys Arg Pro 
                85                  90                  95      


Cys His Glu Asn Cys Thr Gln Gly Cys Lys Gly Pro Glu Leu Gln Asp 
            100                 105                 110         


Cys Leu Gly Gln Thr Leu Val Leu Ile Gly Lys Thr His Leu Thr Met 
        115                 120                 125             


Ala Leu Thr Val Ile Ala Gly Leu Val Val Ile Phe Met Met Leu Gly 
    130                 135                 140                 


Gly Thr Phe Leu Tyr Trp Arg Gly Arg Arg Ile Gln Asn Lys Arg Ala 
145                 150                 155                 160 


Met Arg Arg Tyr Leu Glu Arg Gly Glu Ser Ile Glu Pro Leu Asp Pro 
                165                 170                 175     


Ser Glu Lys Thr Pro Ile Lys Trp Met Ala Leu Glu Ser Ile His Phe 
            180                 185                 190         


Gly Lys Tyr Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val 
        195                 200                 205             


Trp Glu Leu Met Thr Phe Gly Ala Glu Pro Tyr Ala Gly Leu Arg Leu 
    210                 215                 220                 


Ala Glu Val Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Ala Gln Pro 
225                 230                 235                 240 


Gln Ile Cys Thr Ile Asp Val Tyr Met Val Met Val Lys Cys Trp Met 
                245                 250                 255     


Ile Asp Glu Asn Ile Arg Pro Thr Phe Lys Glu Leu Ala Asn Glu Phe 
            260                 265                 270         


Thr Arg Met Ala Arg Asp Pro Pro Arg Tyr Leu Val Ile Lys Arg Glu 
        275                 280                 285             


Ser Gly Pro Gly Ile Ala Pro Gly Pro Glu Pro His Gly Leu Thr Asn 
    290                 295                 300                 


Lys Lys Leu Glu Glu Val Glu Leu Glu Pro Glu Leu Asp Leu Asp Leu 
305                 310                 315                 320 


Asp Leu Glu Ala Glu Glu Asp Asn Leu Ala Thr Thr Thr Leu Gly Ser 
                325                 330                 335     


Ala Leu Ser Leu Pro Val Gly Thr Leu Asn Arg Pro Arg Gly Ser Gln 
            340                 345                 350         


Ser Leu Leu Ser Pro Ser Ser Gly Tyr Met Pro Met Asn Gln Gly Asn 
        355                 360                 365             


Leu Gly Glu Ser Cys Gln Glu Ser Ala Val Ser Gly Ser Ser Glu Arg 
    370                 375                 380                 


Cys Pro Arg Pro Val Ser Leu His Pro Met Pro Arg Gly Cys Leu Ala 
385                 390                 395                 400 


Ser Glu Ser Ser Glu Gly His Val Thr Gly Ser Glu Ala Glu Leu Gln 
                405                 410                 415     


Glu Lys Val Ser Met Cys Arg Ser Arg Ser Arg Ser Arg Ser Pro Arg 
            420                 425                 430         


Pro Arg Gly Asp Ser Ala Tyr His Ser Gln Arg His Ser Leu Leu Thr 
        435                 440                 445             


Pro Val Thr Pro Leu Ser Pro Pro Gly Leu Glu Glu Glu Asp Val Asn 
    450                 455                 460                 


Gly Tyr Val Met Pro Asp Thr His Leu Lys Gly Thr Pro Ser Ser Arg 
465                 470                 475                 480 


Glu Gly Thr Leu Ser Ser Val Gly Leu Ser Ser Val Leu Gly Thr Glu 
                485                 490                 495     


Glu Glu Asp Glu Asp Glu Glu Tyr Glu Tyr Met Asn Arg Arg Arg Arg 
            500                 505                 510         


His Ser Pro Pro His Pro Pro Arg Pro Ser Ser Leu Glu Glu Leu Gly 
        515                 520                 525             


Tyr Glu Tyr Met Asp Val Gly Ser Asp Leu Ser Ala Ser Leu Gly Ser 
    530                 535                 540                 


Thr Gln Ser Cys Pro Leu His Pro Val Pro Ile Met Pro Thr Ala Gly 
545                 550                 555                 560 


Thr Thr Pro Asp Glu Asp Tyr Glu Tyr Met Asn Arg Gln Arg Asp Gly 
                565                 570                 575     


Gly Gly Pro Gly Gly Asp Tyr Ala Ala Met Gly Ala Cys Pro Ala Ser 
            580                 585                 590         


Glu Gln Gly Tyr Glu Glu Met Arg Ala Phe Gln Gly Pro Gly His Gln 
        595                 600                 605             


Ala Pro His Val His Tyr Ala Arg Leu Lys Thr Leu Arg Ser Leu Glu 
    610                 615                 620                 


Ala Thr Asp Ser Ala Phe Asp Asn Pro Asp Tyr Trp His Ser Arg Leu 
625                 630                 635                 640 


Phe Pro Lys Ala Asn Ala Gln Arg Thr 
                645                 


<210>  4869
<211>  81
<212>  PRT
<213>  Homo Sapiens

<400>  4869

Leu Asp Ile Lys His Asn Arg Pro Arg Arg Asp Cys Val Ala Glu Gly 
1               5                   10                  15      


Lys Val Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro Gly 
            20                  25                  30          


Pro Gly Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val Cys 
        35                  40                  45              


Val Thr His Cys Asn Phe Leu Asn Gly Tyr Ser Lys Gly Ser Gln Ser 
    50                  55                  60                  


Arg Met Gly Gly Gly Gly Ala Leu Gln Trp Asn Cys Ser Gly Gly Ile 
65                  70                  75                  80  


Gln 
    


<210>  4870
<211>  19
<212>  PRT
<213>  Homo Sapiens

<400>  4870

Met Gly Asn Leu Glu Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser 
1               5                   10                  15      


Phe Leu Gln 
            


<210>  4871
<211>  115
<212>  PRT
<213>  Homo Sapiens

<400>  4871

Met Gly Asn Leu Glu Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser 
1               5                   10                  15      


Phe Leu Gln Trp Ile Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met 
            20                  25                  30          


Asn Glu Phe Ser Thr Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly 
        35                  40                  45              


Thr Gln Val Tyr Asp Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr 
    50                  55                  60                  


Asn Thr Asn Ser Ser His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu 
65                  70                  75                  80  


Thr Glu Ile Leu Ser Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu 
                85                  90                  95      


Cys His Met Asp Thr Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp 
            100                 105                 110         


Ala Glu Ile 
        115 


<210>  4872
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  4872

Met Gly Asn Leu Glu Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser 
1               5                   10                  15      


Phe Leu Gln Trp Ile Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met 
            20                  25                  30          


Asn Glu Phe Ser Thr Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly 
        35                  40                  45              


Thr Gln Val Tyr Asp Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr 
    50                  55                  60                  


Asn Thr Asn Ser Ser His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu 
65                  70                  75                  80  


Thr Glu Ile Leu Ser Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu 
                85                  90                  95      


Cys His Met Asp Thr Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp 
            100                 105                 110         


Ala Glu Ile Val 
        115     


<210>  4873
<211>  1283
<212>  PRT
<213>  Homo Sapiens

<400>  4873

Met Gly Asn Leu Glu Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser 
1               5                   10                  15      


Phe Leu Gln Trp Ile Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met 
            20                  25                  30          


Asn Glu Phe Ser Thr Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly 
        35                  40                  45              


Thr Gln Val Tyr Asp Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr 
    50                  55                  60                  


Asn Thr Asn Ser Ser His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu 
65                  70                  75                  80  


Thr Glu Ile Leu Ser Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu 
                85                  90                  95      


Cys His Met Asp Thr Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp 
            100                 105                 110         


Ala Glu Ile Val Val Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His 
        115                 120                 125             


Glu Val Cys Lys Gly Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln 
    130                 135                 140                 


Thr Leu Thr Lys Thr Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe 
145                 150                 155                 160 


Gly Pro Asn Pro Asn Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys 
                165                 170                 175     


Ser Gly Pro Gln Asp Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp 
            180                 185                 190         


Ser Gly Ala Cys Val Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys 
        195                 200                 205             


Leu Thr Phe Gln Leu Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly 
    210                 215                 220                 


Gly Val Cys Val Ala Ser Cys Pro His Asn Phe Val Val Asp Gln Thr 
225                 230                 235                 240 


Ser Cys Val Arg Ala Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn 
                245                 250                 255     


Gly Leu Lys Met Cys Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Cys 
            260                 265                 270         


Glu Gly Thr Gly Ser Gly Ser Arg Phe Gln Thr Val Asp Ser Ser Asn 
        275                 280                 285             


Ile Asp Gly Phe Val Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe 
    290                 295                 300                 


Leu Ile Thr Gly Leu Asn Gly Asp Pro Trp His Lys Ile Pro Ala Leu 
305                 310                 315                 320 


Asp Pro Glu Lys Leu Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly 
                325                 330                 335     


Tyr Leu Asn Ile Gln Ser Trp Pro Pro His Met His Asn Phe Ser Val 
            340                 345                 350         


Phe Ser Asn Leu Thr Thr Ile Gly Gly Arg Ser Leu Tyr Asn Arg Gly 
        355                 360                 365             


Phe Ser Leu Leu Ile Met Lys Asn Leu Asn Val Thr Ser Leu Gly Phe 
    370                 375                 380                 


Arg Ser Leu Lys Glu Ile Ser Ala Gly Arg Ile Tyr Ile Ser Ala Asn 
385                 390                 395                 400 


Arg Gln Leu Cys Tyr His His Ser Leu Asn Trp Thr Lys Val Leu Arg 
                405                 410                 415     


Gly Pro Thr Glu Glu Arg Leu Asp Ile Lys His Asn Arg Pro Arg Arg 
            420                 425                 430         


Asp Cys Val Ala Glu Gly Lys Val Cys Asp Pro Leu Cys Ser Ser Gly 
        435                 440                 445             


Gly Cys Trp Gly Pro Gly Pro Gly Gln Cys Leu Ser Cys Arg Asn Tyr 
    450                 455                 460                 


Ser Arg Gly Gly Val Cys Val Thr His Cys Asn Phe Leu Asn Gly Glu 
465                 470                 475                 480 


Pro Arg Glu Phe Ala His Glu Ala Glu Cys Phe Ser Cys His Pro Glu 
                485                 490                 495     


Cys Gln Pro Met Glu Gly Thr Ala Thr Cys Asn Gly Ser Gly Ser Asp 
            500                 505                 510         


Thr Cys Ala Gln Cys Ala His Phe Arg Asp Gly Pro His Cys Val Ser 
        515                 520                 525             


Ser Cys Pro His Gly Val Leu Gly Ala Lys Gly Pro Ile Tyr Lys Tyr 
    530                 535                 540                 


Pro Asp Val Gln Asn Glu Cys Arg Pro Cys His Glu Asn Cys Thr Gln 
545                 550                 555                 560 


Gly Cys Lys Gly Pro Glu Leu Gln Asp Cys Leu Gly Gln Thr Leu Val 
                565                 570                 575     


Leu Ile Gly Lys Thr His Leu Thr Met Ala Leu Thr Val Ile Ala Gly 
            580                 585                 590         


Leu Val Val Ile Phe Met Met Leu Gly Gly Thr Phe Leu Tyr Trp Arg 
        595                 600                 605             


Gly Arg Arg Ile Gln Asn Lys Arg Ala Met Arg Arg Tyr Leu Glu Arg 
    610                 615                 620                 


Gly Glu Ser Ile Glu Pro Leu Asp Pro Ser Glu Lys Ala Asn Lys Val 
625                 630                 635                 640 


Leu Ala Arg Ile Phe Lys Glu Thr Glu Leu Arg Lys Leu Lys Val Leu 
                645                 650                 655     


Gly Ser Gly Val Phe Gly Thr Val His Lys Gly Val Trp Ile Pro Glu 
            660                 665                 670         


Gly Glu Ser Ile Lys Ile Pro Val Cys Ile Lys Val Ile Glu Asp Lys 
        675                 680                 685             


Ser Gly Arg Gln Ser Phe Gln Ala Val Thr Asp His Met Leu Ala Ile 
    690                 695                 700                 


Gly Ser Leu Asp His Ala His Ile Val Arg Leu Leu Gly Leu Cys Pro 
705                 710                 715                 720 


Gly Ser Ser Leu Gln Leu Val Thr Gln Tyr Leu Pro Leu Gly Ser Leu 
                725                 730                 735     


Leu Asp His Val Arg Gln His Arg Gly Ala Leu Gly Pro Gln Leu Leu 
            740                 745                 750         


Leu Asn Trp Gly Val Gln Ile Ala Lys Gly Met Tyr Tyr Leu Glu Glu 
        755                 760                 765             


His Gly Met Val His Arg Asn Leu Ala Ala Arg Asn Val Leu Leu Lys 
    770                 775                 780                 


Ser Pro Ser Gln Val Gln Val Ala Asp Phe Gly Val Ala Asp Leu Leu 
785                 790                 795                 800 


Pro Pro Asp Asp Lys Gln Leu Leu Tyr Ser Glu Ala Lys Thr Pro Ile 
                805                 810                 815     


Lys Trp Met Ala Leu Glu Ser Ile His Phe Gly Lys Tyr Thr His Gln 
            820                 825                 830         


Ser Asp Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe 
        835                 840                 845             


Gly Ala Glu Pro Tyr Ala Gly Leu Arg Leu Ala Glu Val Pro Asp Leu 
    850                 855                 860                 


Leu Glu Lys Gly Glu Arg Leu Ala Gln Pro Gln Ile Cys Thr Ile Asp 
865                 870                 875                 880 


Val Tyr Met Val Met Val Lys Cys Trp Met Ile Asp Glu Asn Ile Arg 
                885                 890                 895     


Pro Thr Phe Lys Glu Leu Ala Asn Glu Phe Thr Arg Met Ala Arg Asp 
            900                 905                 910         


Pro Pro Arg Tyr Leu Val Ile Lys Arg Glu Ser Gly Pro Gly Ile Ala 
        915                 920                 925             


Pro Gly Pro Glu Pro His Gly Leu Thr Asn Lys Lys Leu Glu Glu Val 
    930                 935                 940                 


Glu Leu Glu Pro Glu Leu Asp Leu Asp Leu Asp Leu Glu Ala Glu Glu 
945                 950                 955                 960 


Asp Asn Leu Ala Thr Thr Thr Leu Gly Ser Ala Leu Ser Leu Pro Val 
                965                 970                 975     


Gly Thr Leu Asn Arg Pro Arg Gly Ser Gln Ser Leu Leu Ser Pro Ser 
            980                 985                 990         


Ser Gly Tyr Met Pro Met Asn Gln  Gly Asn Leu Gly Glu  Ser Cys Gln 
        995                 1000                 1005             


Glu Ser  Ala Val Ser Gly Ser  Ser Glu Arg Cys Pro  Arg Pro Val 
    1010                 1015                 1020             


Ser Leu  His Pro Met Pro Arg  Gly Cys Leu Ala Ser  Glu Ser Ser 
    1025                 1030                 1035             


Glu Gly  His Val Thr Gly Ser  Glu Ala Glu Leu Gln  Glu Lys Val 
    1040                 1045                 1050             


Ser Met  Cys Arg Ser Arg Ser  Arg Ser Arg Ser Pro  Arg Pro Arg 
    1055                 1060                 1065             


Gly Asp  Ser Ala Tyr His Ser  Gln Arg His Ser Leu  Leu Thr Pro 
    1070                 1075                 1080             


Val Thr  Pro Leu Ser Pro Pro  Gly Leu Glu Glu Glu  Asp Val Asn 
    1085                 1090                 1095             


Gly Tyr  Val Met Pro Asp Thr  His Leu Lys Gly Thr  Pro Ser Ser 
    1100                 1105                 1110             


Arg Glu  Gly Thr Leu Ser Ser  Val Gly Leu Ser Ser  Val Leu Gly 
    1115                 1120                 1125             


Thr Glu  Glu Glu Asp Glu Asp  Glu Glu Tyr Glu Tyr  Met Asn Arg 
    1130                 1135                 1140             


Arg Arg  Arg His Ser Pro Pro  His Pro Pro Arg Pro  Ser Ser Leu 
    1145                 1150                 1155             


Glu Glu  Leu Gly Tyr Glu Tyr  Met Asp Val Gly Ser  Asp Leu Ser 
    1160                 1165                 1170             


Ala Ser  Leu Gly Ser Thr Gln  Ser Cys Pro Leu His  Pro Val Pro 
    1175                 1180                 1185             


Ile Met  Pro Thr Ala Gly Thr  Thr Pro Asp Glu Asp  Tyr Glu Tyr 
    1190                 1195                 1200             


Met Asn  Arg Gln Arg Asp Gly  Gly Gly Pro Gly Gly  Asp Tyr Ala 
    1205                 1210                 1215             


Ala Met  Gly Ala Cys Pro Ala  Ser Glu Gln Gly Tyr  Glu Glu Met 
    1220                 1225                 1230             


Arg Ala  Phe Gln Gly Pro Gly  His Gln Ala Pro His  Val His Tyr 
    1235                 1240                 1245             


Ala Arg  Leu Lys Thr Leu Arg  Ser Leu Glu Ala Thr  Asp Ser Ala 
    1250                 1255                 1260             


Phe Asp  Asn Pro Asp Tyr Trp  His Ser Arg Leu Phe  Pro Lys Ala 
    1265                 1270                 1275             


Asn Ala  Gln Arg Thr 
    1280             


<210>  4874
<211>  583
<212>  PRT
<213>  Homo Sapiens

<400>  4874

Met Leu Ala Ile Gly Ser Leu Asp His Ala His Ile Val Arg Leu Leu 
1               5                   10                  15      


Gly Leu Cys Pro Gly Ser Ser Leu Gln Leu Val Thr Gln Tyr Leu Pro 
            20                  25                  30          


Leu Gly Ser Leu Leu Asp His Val Arg Gln His Arg Gly Ala Leu Gly 
        35                  40                  45              


Pro Gln Leu Leu Leu Asn Trp Gly Val Gln Ile Ala Lys Gly Met Tyr 
    50                  55                  60                  


Tyr Leu Glu Glu His Gly Met Val His Arg Asn Leu Ala Ala Arg Asn 
65                  70                  75                  80  


Val Leu Leu Lys Ser Pro Ser Gln Val Gln Val Ala Asp Phe Gly Val 
                85                  90                  95      


Ala Asp Leu Leu Pro Pro Asp Asp Lys Gln Leu Leu Tyr Ser Glu Ala 
            100                 105                 110         


Lys Thr Pro Ile Lys Trp Met Ala Leu Glu Ser Ile His Phe Gly Lys 
        115                 120                 125             


Tyr Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val Trp Glu 
    130                 135                 140                 


Leu Met Thr Phe Gly Ala Glu Pro Tyr Ala Gly Leu Arg Leu Ala Glu 
145                 150                 155                 160 


Val Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Ala Gln Pro Gln Ile 
                165                 170                 175     


Cys Thr Ile Asp Val Tyr Met Val Met Val Lys Cys Trp Met Ile Asp 
            180                 185                 190         


Glu Asn Ile Arg Pro Thr Phe Lys Glu Leu Ala Asn Glu Phe Thr Arg 
        195                 200                 205             


Met Ala Arg Asp Pro Pro Arg Tyr Leu Val Ile Lys Arg Glu Ser Gly 
    210                 215                 220                 


Pro Gly Ile Ala Pro Gly Pro Glu Pro His Gly Leu Thr Asn Lys Lys 
225                 230                 235                 240 


Leu Glu Glu Val Glu Leu Glu Pro Glu Leu Asp Leu Asp Leu Asp Leu 
                245                 250                 255     


Glu Ala Glu Glu Asp Asn Leu Ala Thr Thr Thr Leu Gly Ser Ala Leu 
            260                 265                 270         


Ser Leu Pro Val Gly Thr Leu Asn Arg Pro Arg Gly Ser Gln Ser Leu 
        275                 280                 285             


Leu Ser Pro Ser Ser Gly Tyr Met Pro Met Asn Gln Gly Asn Leu Gly 
    290                 295                 300                 


Glu Ser Cys Gln Glu Ser Ala Val Ser Gly Ser Ser Glu Arg Cys Pro 
305                 310                 315                 320 


Arg Pro Val Ser Leu His Pro Met Pro Arg Gly Cys Leu Ala Ser Glu 
                325                 330                 335     


Ser Ser Glu Gly His Val Thr Gly Ser Glu Ala Glu Leu Gln Glu Lys 
            340                 345                 350         


Val Ser Met Cys Arg Ser Arg Ser Arg Ser Arg Ser Pro Arg Pro Arg 
        355                 360                 365             


Gly Asp Ser Ala Tyr His Ser Gln Arg His Ser Leu Leu Thr Pro Val 
    370                 375                 380                 


Thr Pro Leu Ser Pro Pro Gly Leu Glu Glu Glu Asp Val Asn Gly Tyr 
385                 390                 395                 400 


Val Met Pro Asp Thr His Leu Lys Gly Thr Pro Ser Ser Arg Glu Gly 
                405                 410                 415     


Thr Leu Ser Ser Val Gly Leu Ser Ser Val Leu Gly Thr Glu Glu Glu 
            420                 425                 430         


Asp Glu Asp Glu Glu Tyr Glu Tyr Met Asn Arg Arg Arg Arg His Ser 
        435                 440                 445             


Pro Pro His Pro Pro Arg Pro Ser Ser Leu Glu Glu Leu Gly Tyr Glu 
    450                 455                 460                 


Tyr Met Asp Val Gly Ser Asp Leu Ser Ala Ser Leu Gly Ser Thr Gln 
465                 470                 475                 480 


Ser Cys Pro Leu His Pro Val Pro Ile Met Pro Thr Ala Gly Thr Thr 
                485                 490                 495     


Pro Asp Glu Asp Tyr Glu Tyr Met Asn Arg Gln Arg Asp Gly Gly Gly 
            500                 505                 510         


Pro Gly Gly Asp Tyr Ala Ala Met Gly Ala Cys Pro Ala Ser Glu Gln 
        515                 520                 525             


Gly Tyr Glu Glu Met Arg Ala Phe Gln Gly Pro Gly His Gln Ala Pro 
    530                 535                 540                 


His Val His Tyr Ala Arg Leu Lys Thr Leu Arg Ser Leu Glu Ala Thr 
545                 550                 555                 560 


Asp Ser Ala Phe Asp Asn Pro Asp Tyr Trp His Ser Arg Leu Phe Pro 
                565                 570                 575     


Lys Ala Asn Ala Gln Arg Thr 
            580             


<210>  4875
<211>  462
<212>  PRT
<213>  Homo Sapiens

<400>  4875

Met Pro Met Ser Thr Ile Leu Pro Val Thr Ser Pro Cys Leu Pro Ala 
1               5                   10                  15      


Thr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ala Glu Pro Tyr 
            20                  25                  30          


Ala Gly Leu Arg Leu Ala Glu Val Pro Asp Leu Leu Glu Lys Gly Glu 
        35                  40                  45              


Arg Leu Ala Gln Pro Gln Ile Cys Thr Ile Asp Val Tyr Met Val Met 
    50                  55                  60                  


Val Lys Cys Trp Met Ile Asp Glu Asn Ile Arg Pro Thr Phe Lys Glu 
65                  70                  75                  80  


Leu Ala Asn Glu Phe Thr Arg Met Ala Arg Asp Pro Pro Arg Tyr Leu 
                85                  90                  95      


Val Ile Lys Arg Glu Ser Gly Pro Gly Ile Ala Pro Gly Pro Glu Pro 
            100                 105                 110         


His Gly Leu Thr Asn Lys Lys Leu Glu Glu Val Glu Leu Glu Pro Glu 
        115                 120                 125             


Leu Asp Leu Asp Leu Asp Leu Glu Ala Glu Glu Asp Asn Leu Ala Thr 
    130                 135                 140                 


Thr Thr Leu Gly Ser Ala Leu Ser Leu Pro Val Gly Thr Leu Asn Arg 
145                 150                 155                 160 


Pro Arg Gly Ser Gln Ser Leu Leu Ser Pro Ser Ser Gly Tyr Met Pro 
                165                 170                 175     


Met Asn Gln Gly Asn Leu Gly Glu Ser Cys Gln Glu Ser Ala Val Ser 
            180                 185                 190         


Gly Ser Ser Glu Arg Cys Pro Arg Pro Val Ser Leu His Pro Met Pro 
        195                 200                 205             


Arg Gly Cys Leu Ala Ser Glu Ser Ser Glu Gly His Val Thr Gly Ser 
    210                 215                 220                 


Glu Ala Glu Leu Gln Glu Lys Val Ser Met Cys Arg Ser Arg Ser Arg 
225                 230                 235                 240 


Ser Arg Ser Pro Arg Pro Arg Gly Asp Ser Ala Tyr His Ser Gln Arg 
                245                 250                 255     


His Ser Leu Leu Thr Pro Val Thr Pro Leu Ser Pro Pro Gly Leu Glu 
            260                 265                 270         


Glu Glu Asp Val Asn Gly Tyr Val Met Pro Asp Thr His Leu Lys Gly 
        275                 280                 285             


Thr Pro Ser Ser Arg Glu Gly Thr Leu Ser Ser Val Gly Leu Ser Ser 
    290                 295                 300                 


Val Leu Gly Thr Glu Glu Glu Asp Glu Asp Glu Glu Tyr Glu Tyr Met 
305                 310                 315                 320 


Asn Arg Arg Arg Arg His Ser Pro Pro His Pro Pro Arg Pro Ser Ser 
                325                 330                 335     


Leu Glu Glu Leu Gly Tyr Glu Tyr Met Asp Val Gly Ser Asp Leu Ser 
            340                 345                 350         


Ala Ser Leu Gly Ser Thr Gln Ser Cys Pro Leu His Pro Val Pro Ile 
        355                 360                 365             


Met Pro Thr Ala Gly Thr Thr Pro Asp Glu Asp Tyr Glu Tyr Met Asn 
    370                 375                 380                 


Arg Gln Arg Asp Gly Gly Gly Pro Gly Gly Asp Tyr Ala Ala Met Gly 
385                 390                 395                 400 


Ala Cys Pro Ala Ser Glu Gln Gly Tyr Glu Glu Met Arg Ala Phe Gln 
                405                 410                 415     


Gly Pro Gly His Gln Ala Pro His Val His Tyr Ala Arg Leu Lys Thr 
            420                 425                 430         


Leu Arg Ser Leu Glu Ala Thr Asp Ser Ala Phe Asp Asn Pro Asp Tyr 
        435                 440                 445             


Trp His Ser Arg Leu Phe Pro Lys Ala Asn Ala Gln Arg Thr 
    450                 455                 460         


<210>  4876
<211>  126
<212>  PRT
<213>  Homo Sapiens

<400>  4876

Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn 
        115                 120                 125     


<210>  4877
<211>  1342
<212>  PRT
<213>  Homo Sapiens

<400>  4877

Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
        115                 120                 125             


His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser 
    130                 135                 140                 


Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr 
145                 150                 155                 160 


Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val 
                165                 170                 175     


Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly 
            180                 185                 190         


Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr 
        195                 200                 205             


Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn 
    210                 215                 220                 


Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp 
225                 230                 235                 240 


Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 
                245                 250                 255     


Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu 
            260                 265                 270         


Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala 
        275                 280                 285             


Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala 
    290                 295                 300                 


Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys 
305                 310                 315                 320 


Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser 
                325                 330                 335     


Gly Ser Arg Phe Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val 
            340                 345                 350         


Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu 
        355                 360                 365             


Asn Gly Asp Pro Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu 
    370                 375                 380                 


Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln 
385                 390                 395                 400 


Ser Trp Pro Pro His Met His Asn Phe Ser Val Phe Ser Asn Leu Thr 
                405                 410                 415     


Thr Ile Gly Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile 
            420                 425                 430         


Met Lys Asn Leu Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu 
        435                 440                 445             


Ile Ser Ala Gly Arg Ile Tyr Ile Ser Ala Asn Arg Gln Leu Cys Tyr 
    450                 455                 460                 


His His Ser Leu Asn Trp Thr Lys Val Leu Arg Gly Pro Thr Glu Glu 
465                 470                 475                 480 


Arg Leu Asp Ile Lys His Asn Arg Pro Arg Arg Asp Cys Val Ala Glu 
                485                 490                 495     


Gly Lys Val Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro 
            500                 505                 510         


Gly Pro Gly Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val 
        515                 520                 525             


Cys Val Thr His Cys Asn Phe Leu Asn Gly Glu Pro Arg Glu Phe Ala 
    530                 535                 540                 


His Glu Ala Glu Cys Phe Ser Cys His Pro Glu Cys Gln Pro Met Glu 
545                 550                 555                 560 


Gly Thr Ala Thr Cys Asn Gly Ser Gly Ser Asp Thr Cys Ala Gln Cys 
                565                 570                 575     


Ala His Phe Arg Asp Gly Pro His Cys Val Ser Ser Cys Pro His Gly 
            580                 585                 590         


Val Leu Gly Ala Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Val Gln Asn 
        595                 600                 605             


Glu Cys Arg Pro Cys His Glu Asn Cys Thr Gln Gly Cys Lys Gly Pro 
    610                 615                 620                 


Glu Leu Gln Asp Cys Leu Gly Gln Thr Leu Val Leu Ile Gly Lys Thr 
625                 630                 635                 640 


His Leu Thr Met Ala Leu Thr Val Ile Ala Gly Leu Val Val Ile Phe 
                645                 650                 655     


Met Met Leu Gly Gly Thr Phe Leu Tyr Trp Arg Gly Arg Arg Ile Gln 
            660                 665                 670         


Asn Lys Arg Ala Met Arg Arg Tyr Leu Glu Arg Gly Glu Ser Ile Glu 
        675                 680                 685             


Pro Leu Asp Pro Ser Glu Lys Ala Asn Lys Val Leu Ala Arg Ile Phe 
    690                 695                 700                 


Lys Glu Thr Glu Leu Arg Lys Leu Lys Val Leu Gly Ser Gly Val Phe 
705                 710                 715                 720 


Gly Thr Val His Lys Gly Val Trp Ile Pro Glu Gly Glu Ser Ile Lys 
                725                 730                 735     


Ile Pro Val Cys Ile Lys Val Ile Glu Asp Lys Ser Gly Arg Gln Ser 
            740                 745                 750         


Phe Gln Ala Val Thr Asp His Met Leu Ala Ile Gly Ser Leu Asp His 
        755                 760                 765             


Ala His Ile Val Arg Leu Leu Gly Leu Cys Pro Gly Ser Ser Leu Gln 
    770                 775                 780                 


Leu Val Thr Gln Tyr Leu Pro Leu Gly Ser Leu Leu Asp His Val Arg 
785                 790                 795                 800 


Gln His Arg Gly Ala Leu Gly Pro Gln Leu Leu Leu Asn Trp Gly Val 
                805                 810                 815     


Gln Ile Ala Lys Gly Met Tyr Tyr Leu Glu Glu His Gly Met Val His 
            820                 825                 830         


Arg Asn Leu Ala Ala Arg Asn Val Leu Leu Lys Ser Pro Ser Gln Val 
        835                 840                 845             


Gln Val Ala Asp Phe Gly Val Ala Asp Leu Leu Pro Pro Asp Asp Lys 
    850                 855                 860                 


Gln Leu Leu Tyr Ser Glu Ala Lys Thr Pro Ile Lys Trp Met Ala Leu 
865                 870                 875                 880 


Glu Ser Ile His Phe Gly Lys Tyr Thr His Gln Ser Asp Val Trp Ser 
                885                 890                 895     


Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ala Glu Pro Tyr 
            900                 905                 910         


Ala Gly Leu Arg Leu Ala Glu Val Pro Asp Leu Leu Glu Lys Gly Glu 
        915                 920                 925             


Arg Leu Ala Gln Pro Gln Ile Cys Thr Ile Asp Val Tyr Met Val Met 
    930                 935                 940                 


Val Lys Cys Trp Met Ile Asp Glu Asn Ile Arg Pro Thr Phe Lys Glu 
945                 950                 955                 960 


Leu Ala Asn Glu Phe Thr Arg Met Ala Arg Asp Pro Pro Arg Tyr Leu 
                965                 970                 975     


Val Ile Lys Arg Glu Ser Gly Pro Gly Ile Ala Pro Gly Pro Glu Pro 
            980                 985                 990         


His Gly Leu Thr Asn Lys Lys Leu  Glu Glu Val Glu Leu  Glu Pro Glu 
        995                 1000                 1005             


Leu Asp  Leu Asp Leu Asp Leu  Glu Ala Glu Glu Asp  Asn Leu Ala 
    1010                 1015                 1020             


Thr Thr  Thr Leu Gly Ser Ala  Leu Ser Leu Pro Val  Gly Thr Leu 
    1025                 1030                 1035             


Asn Arg  Pro Arg Gly Ser Gln  Ser Leu Leu Ser Pro  Ser Ser Gly 
    1040                 1045                 1050             


Tyr Met  Pro Met Asn Gln Gly  Asn Leu Gly Glu Ser  Cys Gln Glu 
    1055                 1060                 1065             


Ser Ala  Val Ser Gly Ser Ser  Glu Arg Cys Pro Arg  Pro Val Ser 
    1070                 1075                 1080             


Leu His  Pro Met Pro Arg Gly  Cys Leu Ala Ser Glu  Ser Ser Glu 
    1085                 1090                 1095             


Gly His  Val Thr Gly Ser Glu  Ala Glu Leu Gln Glu  Lys Val Ser 
    1100                 1105                 1110             


Met Cys  Arg Ser Arg Ser Arg  Ser Arg Ser Pro Arg  Pro Arg Gly 
    1115                 1120                 1125             


Asp Ser  Ala Tyr His Ser Gln  Arg His Ser Leu Leu  Thr Pro Val 
    1130                 1135                 1140             


Thr Pro  Leu Ser Pro Pro Gly  Leu Glu Glu Glu Asp  Val Asn Gly 
    1145                 1150                 1155             


Tyr Val  Met Pro Asp Thr His  Leu Lys Gly Thr Pro  Ser Ser Arg 
    1160                 1165                 1170             


Glu Gly  Thr Leu Ser Ser Val  Gly Leu Ser Ser Val  Leu Gly Thr 
    1175                 1180                 1185             


Glu Glu  Glu Asp Glu Asp Glu  Glu Tyr Glu Tyr Met  Asn Arg Arg 
    1190                 1195                 1200             


Arg Arg  His Ser Pro Pro His  Pro Pro Arg Pro Ser  Ser Leu Glu 
    1205                 1210                 1215             


Glu Leu  Gly Tyr Glu Tyr Met  Asp Val Gly Ser Asp  Leu Ser Ala 
    1220                 1225                 1230             


Ser Leu  Gly Ser Thr Gln Ser  Cys Pro Leu His Pro  Val Pro Ile 
    1235                 1240                 1245             


Met Pro  Thr Ala Gly Thr Thr  Pro Asp Glu Asp Tyr  Glu Tyr Met 
    1250                 1255                 1260             


Asn Arg  Gln Arg Asp Gly Gly  Gly Pro Gly Gly Asp  Tyr Ala Ala 
    1265                 1270                 1275             


Met Gly  Ala Cys Pro Ala Ser  Glu Gln Gly Tyr Glu  Glu Met Arg 
    1280                 1285                 1290             


Ala Phe  Gln Gly Pro Gly His  Gln Ala Pro His Val  His Tyr Ala 
    1295                 1300                 1305             


Arg Leu  Lys Thr Leu Arg Ser  Leu Glu Ala Thr Asp  Ser Ala Phe 
    1310                 1315                 1320             


Asp Asn  Pro Asp Tyr Trp His  Ser Arg Leu Phe Pro  Lys Ala Asn 
    1325                 1330                 1335             


Ala Gln  Arg Thr 
    1340         


<210>  4878
<211>  921
<212>  PRT
<213>  Homo Sapiens

<400>  4878

Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
        115                 120                 125             


His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser 
    130                 135                 140                 


Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr 
145                 150                 155                 160 


Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val 
                165                 170                 175     


Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly 
            180                 185                 190         


Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr 
        195                 200                 205             


Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn 
    210                 215                 220                 


Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp 
225                 230                 235                 240 


Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 
                245                 250                 255     


Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu 
            260                 265                 270         


Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala 
        275                 280                 285             


Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala 
    290                 295                 300                 


Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys 
305                 310                 315                 320 


Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser 
                325                 330                 335     


Gly Ser Arg Phe Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val 
            340                 345                 350         


Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu 
        355                 360                 365             


Asn Gly Asp Pro Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu 
    370                 375                 380                 


Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln 
385                 390                 395                 400 


Ser Trp Pro Pro His Met His Asn Phe Ser Val Phe Ser Asn Leu Thr 
                405                 410                 415     


Thr Ile Gly Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile 
            420                 425                 430         


Met Lys Asn Leu Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu 
        435                 440                 445             


Ile Ser Ala Gly Arg Ile Tyr Ile Ser Ala Asn Arg Gln Leu Cys Tyr 
    450                 455                 460                 


His His Ser Leu Asn Trp Thr Lys Val Leu Arg Gly Pro Thr Glu Glu 
465                 470                 475                 480 


Arg Leu Asp Ile Lys His Asn Arg Pro Arg Arg Asp Cys Val Ala Glu 
                485                 490                 495     


Gly Lys Val Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro 
            500                 505                 510         


Gly Pro Gly Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val 
        515                 520                 525             


Cys Val Thr His Cys Asn Phe Leu Asn Gly Glu Pro Arg Glu Phe Ala 
    530                 535                 540                 


His Glu Ala Glu Cys Phe Ser Cys His Pro Glu Cys Gln Pro Met Glu 
545                 550                 555                 560 


Gly Thr Ala Thr Cys Asn Gly Ser Gly Ser Asp Thr Cys Ala Gln Cys 
                565                 570                 575     


Ala His Phe Arg Asp Gly Pro His Cys Val Ser Ser Cys Pro His Gly 
            580                 585                 590         


Val Leu Gly Ala Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Val Gln Asn 
        595                 600                 605             


Glu Cys Arg Pro Cys His Glu Asn Cys Thr Gln Gly Cys Lys Gly Pro 
    610                 615                 620                 


Glu Leu Gln Asp Cys Leu Gly Gln Thr Leu Val Leu Ile Gly Lys Thr 
625                 630                 635                 640 


His Leu Thr Met Ala Leu Thr Val Ile Ala Gly Leu Val Val Ile Phe 
                645                 650                 655     


Met Met Leu Gly Gly Thr Phe Leu Tyr Trp Arg Gly Arg Arg Ile Gln 
            660                 665                 670         


Asn Lys Arg Ala Met Arg Arg Tyr Leu Glu Arg Gly Glu Ser Ile Glu 
        675                 680                 685             


Pro Leu Asp Pro Ser Glu Lys Ala Asn Lys Val Leu Ala Arg Ile Phe 
    690                 695                 700                 


Lys Glu Thr Glu Leu Arg Lys Leu Lys Val Leu Gly Ser Gly Val Phe 
705                 710                 715                 720 


Gly Thr Val His Lys Gly Val Trp Ile Pro Glu Gly Glu Ser Ile Lys 
                725                 730                 735     


Ile Pro Val Cys Ile Lys Val Ile Glu Asp Lys Ser Gly Arg Gln Ser 
            740                 745                 750         


Phe Gln Ala Val Thr Asp His Met Leu Ala Ile Gly Ser Leu Asp His 
        755                 760                 765             


Ala His Ile Val Arg Leu Leu Gly Leu Cys Pro Gly Ser Ser Leu Gln 
    770                 775                 780                 


Leu Val Thr Gln Tyr Leu Pro Leu Gly Ser Leu Leu Asp His Val Arg 
785                 790                 795                 800 


Gln His Arg Gly Ala Leu Gly Pro Gln Leu Leu Leu Asn Trp Gly Val 
                805                 810                 815     


Gln Ile Ala Lys Gly Met Tyr Tyr Leu Glu Glu His Gly Met Val His 
            820                 825                 830         


Arg Asn Leu Ala Ala Arg Asn Val Leu Leu Lys Ser Pro Ser Gln Val 
        835                 840                 845             


Gln Val Ala Asp Phe Gly Val Ala Asp Leu Leu Pro Pro Asp Asp Lys 
    850                 855                 860                 


Gln Leu Leu Tyr Ser Glu Ala Lys Thr Pro Ile Lys Trp Met Ala Leu 
865                 870                 875                 880 


Glu Ser Ile His Phe Gly Lys Tyr Thr His Gln Ser Asp Val Trp Ser 
                885                 890                 895     


Tyr Gly Gln Cys Ile Trp Met Pro Ser Leu Pro Ser Leu Ala Pro Val 
            900                 905                 910         


Ser Asn Leu Pro Phe Glu Thr Pro Ser 
        915                 920     


<210>  4879
<211>  331
<212>  PRT
<213>  Homo Sapiens

<400>  4879

Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
        115                 120                 125             


His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser 
    130                 135                 140                 


Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr 
145                 150                 155                 160 


Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val 
                165                 170                 175     


Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly 
            180                 185                 190         


Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr 
        195                 200                 205             


Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn 
    210                 215                 220                 


Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp 
225                 230                 235                 240 


Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 
                245                 250                 255     


Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu 
            260                 265                 270         


Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala 
        275                 280                 285             


Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala 
    290                 295                 300                 


Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys 
305                 310                 315                 320 


Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Phe 
                325                 330     


<210>  4880
<211>  183
<212>  PRT
<213>  Homo Sapiens

<400>  4880

Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
        115                 120                 125             


His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Gly Gln Phe Pro 
    130                 135                 140                 


Met Val Pro Ser Gly Leu Thr Pro Gln Pro Ala Gln Asp Trp Tyr Leu 
145                 150                 155                 160 


Leu Asp Asp Asp Pro Arg Leu Leu Thr Leu Ser Ala Ser Ser Lys Val 
                165                 170                 175     


Pro Val Thr Leu Ala Ala Val 
            180             


<210>  4881
<211>  43
<212>  PRT
<213>  Homo Sapiens

<400>  4881

Met Arg Ala Asn Asp Ala Leu Gln Val Pro Arg Ala Gln Ser Thr Ser 
1               5                   10                  15      


Thr Gln Met Phe Arg Met Asn Val Gly Pro Ala Met Arg Thr Ala Pro 
            20                  25                  30          


Arg Gly Val Lys Asp Gln Ser Phe Lys Thr Val 
        35                  40              


<210>  4882
<211>  354
<212>  PRT
<213>  Homo Sapiens

<400>  4882

Met Ala Pro Ala Arg Arg Pro Ala Gly Ala Arg Leu Leu Leu Val Tyr 
1               5                   10                  15      


Ala Gly Leu Leu Ala Ala Ala Ala Ala Gly Leu Gly Ser Pro Glu Pro 
            20                  25                  30          


Gly Ala Pro Ser Arg Ser Arg Ala Arg Arg Glu Pro Pro Pro Gly Asn 
        35                  40                  45              


Glu Leu Pro Arg Gly Pro Gly Glu Ser Arg Ala Gly Pro Ala Ala Arg 
    50                  55                  60                  


Pro Pro Glu Pro Thr Ala Glu Arg Ala His Ser Val Asp Pro Arg Asp 
65                  70                  75                  80  


Ala Trp Met Leu Phe Val Arg Gln Ser Asp Lys Gly Val Asn Gly Lys 
                85                  90                  95      


Lys Arg Ser Arg Gly Lys Ala Lys Lys Leu Lys Phe Gly Leu Pro Gly 
            100                 105                 110         


Pro Pro Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly Pro Ile Ile Pro 
        115                 120                 125             


Pro Glu Ala Leu Leu Lys Glu Phe Gln Leu Leu Leu Lys Gly Ala Val 
    130                 135                 140                 


Arg Gln Arg Glu Arg Ala Glu Pro Glu Pro Cys Thr Cys Gly Pro Ala 
145                 150                 155                 160 


Gly Pro Val Ala Ala Ser Leu Ala Pro Val Ser Ala Thr Ala Gly Glu 
                165                 170                 175     


Asp Asp Asp Asp Val Val Gly Asp Val Leu Ala Leu Leu Ala Ala Pro 
            180                 185                 190         


Leu Ala Pro Gly Pro Arg Ala Pro Arg Val Glu Ala Ala Phe Leu Cys 
        195                 200                 205             


Arg Leu Arg Arg Asp Ala Leu Val Glu Arg Arg Ala Leu His Glu Leu 
    210                 215                 220                 


Gly Val Tyr Tyr Leu Pro Asp Ala Glu Gly Ala Phe Arg Arg Gly Pro 
225                 230                 235                 240 


Gly Leu Asn Leu Thr Ser Gly Gln Tyr Arg Ala Pro Val Ala Gly Phe 
                245                 250                 255     


Tyr Ala Leu Ala Ala Thr Leu His Val Ala Leu Gly Glu Pro Pro Arg 
            260                 265                 270         


Arg Gly Pro Pro Arg Pro Arg Asp His Leu Arg Leu Leu Ile Cys Ile 
        275                 280                 285             


Gln Ser Arg Cys Gln Arg Asn Ala Ser Leu Glu Ala Ile Met Gly Leu 
    290                 295                 300                 


Glu Ser Ser Ser Glu Leu Phe Thr Ile Ser Val Asn Gly Val Leu Tyr 
305                 310                 315                 320 


Leu Gln Met Gly Gln Trp Thr Ser Val Phe Leu Asp Asn Ala Ser Gly 
                325                 330                 335     


Cys Ser Leu Thr Val Arg Ser Gly Ser His Phe Ser Ala Val Leu Leu 
            340                 345                 350         


Gly Val 
        


<210>  4883
<211>  63
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4883

Xaa Phe Gly Tyr Ser Ser Leu Glu Ala Ile Met Gly Leu Glu Ser Ser 
1               5                   10                  15      


Ser Glu Leu Phe Thr Ile Ser Val Asn Gly Val Leu Tyr Leu Gln Met 
            20                  25                  30          


Gly Gln Trp Thr Ser Val Phe Leu Asp Asn Ala Ser Gly Cys Ser Leu 
        35                  40                  45              


Thr Val Arg Ser Gly Ser His Phe Ser Ala Val Leu Leu Gly Val 
    50                  55                  60              


<210>  4884
<211>  74
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4884

Xaa Ile Gln Ser Arg Cys Gln Arg Asn Ala Ser Leu Glu Ala Ile Met 
1               5                   10                  15      


Gly Leu Glu Ser Ser Ser Glu Leu Phe Thr Ile Ser Val Asn Gly Val 
            20                  25                  30          


Leu Tyr Leu Gln Ala Thr Lys Asn Leu Val Pro Gln Asp Leu Leu Gly 
        35                  40                  45              


Ala Lys Leu Val Trp Gln Gly Arg Ser Gly Leu Gly Glu Lys Gly Ala 
    50                  55                  60                  


Met Ala Ser His Leu His Leu Leu Thr Asn 
65                  70                  


<210>  4885
<211>  275
<212>  PRT
<213>  Homo Sapiens

<400>  4885

Met Asn Met Thr Gln Ala Arg Val Leu Val Ala Ala Val Val Gly Leu 
1               5                   10                  15      


Val Ala Val Leu Leu Tyr Ala Ser Ile His Lys Ile Glu Glu Gly His 
            20                  25                  30          


Leu Ala Val Tyr Tyr Arg Gly Gly Ala Leu Leu Thr Ser Pro Ser Gly 
        35                  40                  45              


Pro Gly Tyr His Ile Met Leu Pro Phe Ile Thr Thr Phe Arg Ser Val 
    50                  55                  60                  


Gln Thr Thr Leu Gln Thr Asp Glu Val Lys Asn Val Pro Cys Gly Thr 
65                  70                  75                  80  


Ser Gly Gly Val Met Ile Tyr Ile Asp Arg Ile Glu Val Val Asn Met 
                85                  90                  95      


Leu Ala Pro Tyr Ala Val Phe Asp Ile Val Arg Asn Tyr Thr Ala Asp 
            100                 105                 110         


Tyr Asp Lys Thr Leu Ile Phe Asn Lys Ile His His Glu Leu Asn Gln 
        115                 120                 125             


Phe Cys Ser Ala His Thr Leu Gln Glu Val Tyr Ile Glu Leu Phe Asp 
    130                 135                 140                 


Gln Ile Asp Glu Asn Leu Lys Gln Ala Leu Gln Lys Asp Leu Asn Leu 
145                 150                 155                 160 


Met Ala Pro Gly Leu Thr Ile Gln Ala Val Arg Val Thr Lys Pro Lys 
                165                 170                 175     


Ile Pro Glu Ala Ile Arg Arg Asn Phe Glu Leu Met Glu Ala Glu Lys 
            180                 185                 190         


Thr Lys Leu Leu Ile Ala Ala Gln Lys Gln Lys Val Val Glu Lys Glu 
        195                 200                 205             


Ala Glu Thr Glu Arg Lys Lys Ala Val Ile Glu Ala Glu Lys Ile Ala 
    210                 215                 220                 


Gln Val Ala Lys Ile Arg Phe Gln Gln Lys Val Met Glu Lys Glu Thr 
225                 230                 235                 240 


Glu Lys Arg Ile Ser Glu Ile Glu Asp Ala Ala Phe Leu Ala Arg Glu 
                245                 250                 255     


Lys Ala Lys Ala Asp Ala Glu Tyr Tyr Ala Ala His Lys Tyr Ala Thr 
            260                 265                 270         


Ser Asn Lys 
        275 


<210>  4886
<211>  348
<212>  PRT
<213>  Homo Sapiens

<400>  4886

Met Asn Met Thr Gln Ala Arg Val Leu Val Ala Ala Val Val Gly Leu 
1               5                   10                  15      


Val Ala Val Leu Leu Tyr Ala Ser Ile His Lys Ile Glu Glu Gly His 
            20                  25                  30          


Leu Ala Val Tyr Tyr Arg Gly Gly Ala Leu Leu Thr Ser Pro Ser Gly 
        35                  40                  45              


Pro Gly Tyr His Ile Met Leu Pro Phe Ile Thr Thr Phe Arg Ser Val 
    50                  55                  60                  


Gln Thr Thr Leu Gln Thr Asp Glu Val Lys Asn Val Pro Cys Gly Thr 
65                  70                  75                  80  


Ser Gly Gly Val Met Ile Tyr Ile Asp Arg Ile Glu Val Val Asn Met 
                85                  90                  95      


Leu Ala Pro Tyr Ala Val Phe Asp Ile Val Arg Asn Tyr Thr Ala Asp 
            100                 105                 110         


Tyr Asp Lys Thr Leu Ile Phe Asn Lys Ile His His Glu Leu Asn Gln 
        115                 120                 125             


Phe Cys Ser Ala His Thr Leu Gln Glu Val Tyr Ile Glu Leu Phe Asp 
    130                 135                 140                 


Gln Ile Asp Glu Asn Leu Lys Gln Ala Leu Gln Lys Asp Leu Asn Leu 
145                 150                 155                 160 


Met Ala Pro Gly Leu Thr Ile Gln Ala Val Arg Val Thr Lys Pro Lys 
                165                 170                 175     


Ile Pro Glu Ala Ile Arg Arg Asn Phe Glu Leu Met Glu Ala Glu Lys 
            180                 185                 190         


Thr Lys Leu Leu Ile Ala Ala Gln Lys Gln Lys Val Val Glu Lys Glu 
        195                 200                 205             


Ala Glu Thr Glu Arg Lys Lys Ala Val Ile Glu Ala Glu Lys Ile Ala 
    210                 215                 220                 


Gln Val Ala Lys Ile Arg Phe Gln Gln Lys Val Met Glu Lys Glu Thr 
225                 230                 235                 240 


Glu Lys Arg Ile Ser Glu Ile Glu Asp Ala Ala Phe Leu Ala Arg Glu 
                245                 250                 255     


Lys Ala Lys Ala Asp Ala Glu Tyr Tyr Ala Ala His Lys Tyr Ala Thr 
            260                 265                 270         


Ser Asn Lys His Lys Leu Thr Pro Glu Tyr Leu Glu Leu Lys Lys Tyr 
        275                 280                 285             


Gln Ala Ile Ala Ser Asn Ser Lys Ile Tyr Phe Gly Ser Asn Ile Pro 
    290                 295                 300                 


Asn Met Phe Val Asp Ser Ser Cys Ala Leu Lys Tyr Ser Asp Ile Arg 
305                 310                 315                 320 


Thr Gly Arg Glu Ser Ser Leu Pro Ser Lys Glu Ala Leu Glu Pro Ser 
                325                 330                 335     


Gly Glu Asn Val Ile Gln Asn Lys Glu Ser Thr Gly 
            340                 345             


<210>  4887
<211>  348
<212>  PRT
<213>  Homo Sapiens

<400>  4887

Met Asn Met Thr Gln Ala Arg Val Leu Val Ala Ala Val Val Gly Leu 
1               5                   10                  15      


Val Ala Val Leu Leu Tyr Ala Ser Ile His Lys Ile Glu Glu Gly His 
            20                  25                  30          


Leu Ala Val Tyr Tyr Arg Gly Gly Ala Leu Leu Thr Ser Pro Ser Gly 
        35                  40                  45              


Pro Gly Tyr His Ile Met Leu Pro Phe Ile Thr Thr Phe Arg Ser Val 
    50                  55                  60                  


Gln Thr Thr Leu Gln Thr Asp Glu Val Lys Asn Val Pro Cys Gly Thr 
65                  70                  75                  80  


Ser Gly Gly Val Met Ile Tyr Ile Asp Arg Ile Glu Val Val Asn Met 
                85                  90                  95      


Leu Ala Pro Tyr Ala Val Phe Asp Ile Val Arg Asn Tyr Thr Ala Asp 
            100                 105                 110         


Tyr Asp Lys Thr Leu Ile Phe Asn Lys Ile His His Glu Leu Asn Gln 
        115                 120                 125             


Phe Cys Ser Ala His Thr Leu Gln Glu Val Tyr Ile Glu Leu Phe Asp 
    130                 135                 140                 


Gln Ile Asp Glu Asn Leu Lys Gln Ala Leu Gln Lys Asp Leu Asn Leu 
145                 150                 155                 160 


Met Ala Pro Gly Leu Thr Ile Gln Ala Val Arg Val Thr Lys Pro Lys 
                165                 170                 175     


Ile Pro Glu Ala Ile Arg Arg Asn Phe Glu Leu Met Glu Ala Glu Lys 
            180                 185                 190         


Thr Lys Leu Leu Ile Ala Ala Gln Lys Gln Lys Val Val Glu Lys Glu 
        195                 200                 205             


Ala Glu Thr Glu Arg Lys Lys Ala Val Ile Glu Ala Glu Lys Ile Ala 
    210                 215                 220                 


Gln Val Ala Lys Ile Arg Phe Gln Gln Lys Val Met Glu Lys Glu Thr 
225                 230                 235                 240 


Glu Lys Arg Ile Ser Glu Ile Glu Asp Ala Ala Phe Leu Ala Arg Glu 
                245                 250                 255     


Lys Ala Lys Ala Asp Ala Glu Tyr Tyr Ala Ala His Lys Tyr Ala Thr 
            260                 265                 270         


Ser Asn Lys His Lys Leu Thr Pro Glu Tyr Leu Glu Leu Lys Lys Tyr 
        275                 280                 285             


Gln Ala Ile Ala Ser Asn Ser Lys Ile Tyr Phe Gly Ser Asn Ile Pro 
    290                 295                 300                 


Asn Met Phe Val Asp Ser Ser Cys Ala Leu Lys Tyr Ser Asp Ile Arg 
305                 310                 315                 320 


Thr Gly Arg Glu Ser Ser Leu Pro Ser Lys Glu Ala Leu Glu Pro Ser 
                325                 330                 335     


Gly Glu Asn Val Ile Gln Asn Lys Glu Ser Thr Gly 
            340                 345             


<210>  4888
<211>  339
<212>  PRT
<213>  Homo Sapiens

<400>  4888

Met Ala Gln Leu Gly Ala Val Val Ala Val Ala Ser Ser Phe Phe Cys 
1               5                   10                  15      


Ala Ser Leu Phe Ser Ala Val His Lys Ile Glu Glu Gly His Ile Gly 
            20                  25                  30          


Val Tyr Tyr Arg Gly Gly Ala Leu Leu Thr Ser Thr Ser Gly Pro Gly 
        35                  40                  45              


Phe His Leu Met Leu Pro Phe Ile Thr Ser Tyr Lys Ser Val Gln Thr 
    50                  55                  60                  


Thr Leu Gln Thr Asp Glu Val Lys Asn Val Pro Cys Gly Thr Ser Gly 
65                  70                  75                  80  


Gly Val Met Ile Tyr Phe Asp Arg Ile Glu Val Val Asn Phe Leu Val 
                85                  90                  95      


Pro Asn Ala Val Tyr Asp Ile Val Lys Asn Tyr Thr Ala Asp Tyr Asp 
            100                 105                 110         


Lys Ala Leu Ile Phe Asn Lys Ile His His Glu Leu Asn Gln Phe Cys 
        115                 120                 125             


Ser Val His Thr Leu Gln Glu Val Tyr Ile Glu Leu Phe Asp Gln Ile 
    130                 135                 140                 


Asp Glu Asn Leu Lys Leu Ala Leu Gln Gln Asp Leu Thr Ser Met Ala 
145                 150                 155                 160 


Pro Gly Leu Val Ile Gln Ala Val Arg Val Thr Lys Pro Asn Ile Pro 
                165                 170                 175     


Glu Ala Ile Arg Arg Asn Tyr Glu Leu Met Glu Ser Glu Lys Thr Lys 
            180                 185                 190         


Leu Leu Ile Ala Ala Gln Lys Gln Lys Val Val Glu Lys Glu Ala Glu 
        195                 200                 205             


Thr Glu Arg Lys Lys Ala Leu Ile Glu Ala Glu Lys Val Ala Gln Val 
    210                 215                 220                 


Ala Glu Ile Thr Tyr Gly Gln Lys Val Met Glu Lys Glu Thr Glu Lys 
225                 230                 235                 240 


Lys Ile Ser Glu Ile Glu Asp Ala Ala Phe Leu Ala Arg Glu Lys Ala 
                245                 250                 255     


Lys Ala Asp Ala Glu Cys Tyr Thr Ala Met Lys Ile Ala Glu Ala Asn 
            260                 265                 270         


Lys Leu Lys Leu Thr Pro Glu Tyr Leu Gln Leu Met Lys Tyr Lys Ala 
        275                 280                 285             


Ile Ala Ser Asn Ser Lys Ile Tyr Phe Gly Lys Asp Ile Pro Asn Met 
    290                 295                 300                 


Phe Met Asp Ser Ala Gly Ser Val Ser Lys Gln Phe Glu Gly Leu Ala 
305                 310                 315                 320 


Asp Lys Leu Ser Phe Gly Leu Glu Asp Glu Pro Leu Glu Thr Ala Thr 
                325                 330                 335     


Lys Glu Asn 
            


<210>  4889
<211>  339
<212>  PRT
<213>  Homo Sapiens

<400>  4889

Met Ala Gln Leu Gly Ala Val Val Ala Val Ala Ser Ser Phe Phe Cys 
1               5                   10                  15      


Ala Ser Leu Phe Ser Ala Val His Lys Ile Glu Glu Gly His Ile Gly 
            20                  25                  30          


Val Tyr Tyr Arg Gly Gly Ala Leu Leu Thr Ser Thr Ser Gly Pro Gly 
        35                  40                  45              


Phe His Leu Met Leu Pro Phe Ile Thr Ser Tyr Lys Ser Val Gln Thr 
    50                  55                  60                  


Thr Leu Gln Thr Asp Glu Val Lys Asn Val Pro Cys Gly Thr Ser Gly 
65                  70                  75                  80  


Gly Val Met Ile Tyr Phe Asp Arg Ile Glu Val Val Asn Phe Leu Val 
                85                  90                  95      


Pro Asn Ala Val Tyr Asp Ile Val Lys Asn Tyr Thr Ala Asp Tyr Asp 
            100                 105                 110         


Lys Ala Leu Ile Phe Asn Lys Ile His His Glu Leu Asn Gln Phe Cys 
        115                 120                 125             


Ser Val His Thr Leu Gln Glu Val Tyr Ile Glu Leu Phe Asp Gln Ile 
    130                 135                 140                 


Asp Glu Asn Leu Lys Leu Ala Leu Gln Gln Asp Leu Thr Ser Met Ala 
145                 150                 155                 160 


Pro Gly Leu Val Ile Gln Ala Val Arg Val Thr Lys Pro Asn Ile Pro 
                165                 170                 175     


Glu Ala Ile Arg Arg Asn Tyr Glu Leu Met Glu Ser Glu Lys Thr Lys 
            180                 185                 190         


Leu Leu Ile Ala Ala Gln Lys Gln Lys Val Val Glu Lys Glu Ala Glu 
        195                 200                 205             


Thr Glu Arg Lys Lys Ala Leu Ile Glu Ala Glu Lys Val Ala Gln Val 
    210                 215                 220                 


Ala Glu Ile Thr Tyr Gly Gln Lys Val Met Glu Lys Glu Thr Glu Lys 
225                 230                 235                 240 


Lys Ile Ser Glu Ile Glu Asp Ala Ala Phe Leu Ala Arg Glu Lys Ala 
                245                 250                 255     


Lys Ala Asp Ala Glu Cys Tyr Thr Ala Met Lys Ile Ala Glu Ala Asn 
            260                 265                 270         


Lys Leu Lys Leu Thr Pro Glu Tyr Leu Gln Leu Met Lys Tyr Lys Ala 
        275                 280                 285             


Ile Ala Ser Asn Ser Lys Ile Tyr Phe Gly Lys Asp Ile Pro Asn Met 
    290                 295                 300                 


Phe Met Asp Ser Ala Gly Ser Val Ser Lys Gln Phe Glu Gly Leu Ala 
305                 310                 315                 320 


Asp Lys Leu Ser Phe Gly Leu Glu Asp Glu Pro Leu Glu Thr Ala Thr 
                325                 330                 335     


Lys Glu Asn 
            


<210>  4890
<211>  338
<212>  PRT
<213>  Homo Sapiens

<400>  4890

Met Ala Gln Leu Gly Ala Val Val Ala Val Ala Ser Ser Phe Phe Cys 
1               5                   10                  15      


Ala Ser Leu Phe Ser Ala Val His Lys Ile Glu Glu Gly His Ile Gly 
            20                  25                  30          


Val Tyr Tyr Arg Gly Gly Ala Leu Leu Thr Ser Thr Ser Gly Pro Gly 
        35                  40                  45              


Phe His Leu Met Leu Pro Phe Ile Thr Ser Tyr Lys Ser Val Gln Thr 
    50                  55                  60                  


Thr Leu Gln Thr Asp Glu Val Lys Asn Val Pro Cys Gly Thr Ser Gly 
65                  70                  75                  80  


Gly Val Met Ile Tyr Phe Asp Arg Ile Glu Val Val Asn Phe Leu Val 
                85                  90                  95      


Pro Asn Ala Val Tyr Asp Ile Val Lys Asn Tyr Thr Ala Asp Tyr Asp 
            100                 105                 110         


Lys Ala Leu Ile Phe Asn Lys Ile His His Glu Leu Asn Gln Phe Cys 
        115                 120                 125             


Ser Val His Thr Leu Gln Glu Val Tyr Ile Glu Leu Phe Asp Gln Ile 
    130                 135                 140                 


Asp Glu Asn Leu Lys Leu Ala Leu Gln Gln Asp Leu Thr Ser Met Ala 
145                 150                 155                 160 


Pro Gly Leu Val Ile Gln Ala Val Arg Val Thr Lys Pro Asn Ile Pro 
                165                 170                 175     


Glu Ala Ile Arg Arg Asn Tyr Glu Leu Met Glu Ser Glu Lys Thr Lys 
            180                 185                 190         


Leu Leu Ile Ala Ala Gln Lys Gln Lys Val Val Glu Lys Glu Ala Glu 
        195                 200                 205             


Thr Glu Arg Lys Lys Ala Leu Ile Glu Ala Glu Lys Val Ala Gln Val 
    210                 215                 220                 


Ala Glu Ile Thr Tyr Gly Gln Lys Val Met Glu Lys Glu Thr Glu Lys 
225                 230                 235                 240 


Lys Ile Ser Glu Ile Glu Asp Ala Ala Phe Leu Ala Arg Glu Lys Ala 
                245                 250                 255     


Lys Ala Asp Ala Glu Cys Tyr Thr Ala Met Lys Ile Ala Glu Ala Asn 
            260                 265                 270         


Lys Leu Lys Leu Thr Pro Glu Tyr Leu Gln Leu Met Lys Tyr Lys Ala 
        275                 280                 285             


Ile Ala Ser Asn Ser Lys Ile Tyr Phe Gly Lys Asp Ile Pro Asn Met 
    290                 295                 300                 


Phe Met Asp Ser Ala Gly Ser Val Ser Lys Gln Phe Glu Gly Leu Ala 
305                 310                 315                 320 


Asp Lys Leu Ser Phe Gly Leu Glu Asp Glu Pro Leu Glu Thr Ala Thr 
                325                 330                 335     


Lys Glu 
        


<210>  4891
<211>  206
<212>  PRT
<213>  Homo Sapiens

<400>  4891

Met Ala Gln Leu Gly Ala Val Val Ala Val Ala Ser Ser Phe Phe Cys 
1               5                   10                  15      


Ala Ser Leu Phe Ser Ala Val His Lys Ile Glu Glu Gly His Ile Gly 
            20                  25                  30          


Val Tyr Tyr Arg Gly Gly Ala Leu Leu Thr Ser Thr Ser Gly Pro Gly 
        35                  40                  45              


Phe His Leu Met Leu Pro Phe Ile Thr Ser Tyr Lys Ser Val Gln Thr 
    50                  55                  60                  


Thr Leu Gln Thr Asp Glu Val Lys Asn Val Pro Cys Gly Thr Ser Gly 
65                  70                  75                  80  


Gly Val Met Ile Tyr Phe Asp Arg Ile Glu Val Val Asn Phe Leu Val 
                85                  90                  95      


Pro Asn Ala Val Tyr Asp Ile Val Lys Asn Tyr Thr Ala Asp Tyr Asp 
            100                 105                 110         


Lys Ala Leu Ile Phe Asn Lys Ile His His Glu Leu Asn Gln Phe Cys 
        115                 120                 125             


Ser Val His Thr Leu Gln Glu Val Tyr Ile Glu Leu Phe Gly Lys Lys 
    130                 135                 140                 


Val Ser Pro Glu His Ala Val Leu Lys Gln Gly Ser Trp Asn Pro Ala 
145                 150                 155                 160 


Ser Leu His Cys Leu Lys Pro Gly Cys Leu Gln Gly Val Met Val Thr 
                165                 170                 175     


Tyr Gly Gln Glu Met Leu Lys Asn Leu Val Leu Arg Ser Trp Ser Gln 
            180                 185                 190         


Arg Ser Ser Trp Arg Met Leu Ile Ala Met Gln Gln Asp Pro 
        195                 200                 205     


<210>  4892
<211>  206
<212>  PRT
<213>  Homo Sapiens

<400>  4892

Met Ala Gln Leu Gly Ala Val Val Ala Val Ala Ser Ser Phe Phe Cys 
1               5                   10                  15      


Ala Ser Leu Phe Ser Ala Val His Lys Ile Glu Glu Gly His Ile Gly 
            20                  25                  30          


Val Tyr Tyr Arg Gly Gly Ala Leu Leu Thr Ser Thr Ser Gly Pro Gly 
        35                  40                  45              


Phe His Leu Met Leu Pro Phe Ile Thr Ser Tyr Lys Ser Val Gln Thr 
    50                  55                  60                  


Thr Leu Gln Thr Asp Glu Val Lys Asn Val Pro Cys Gly Thr Ser Gly 
65                  70                  75                  80  


Gly Val Met Ile Tyr Phe Asp Arg Ile Glu Val Val Asn Phe Leu Val 
                85                  90                  95      


Pro Asn Ala Val Tyr Asp Ile Val Lys Asn Tyr Thr Ala Asp Tyr Asp 
            100                 105                 110         


Lys Ala Leu Ile Phe Asn Lys Ile His His Glu Leu Asn Gln Phe Cys 
        115                 120                 125             


Ser Val His Thr Leu Gln Glu Val Tyr Ile Glu Leu Phe Gly Lys Lys 
    130                 135                 140                 


Val Ser Pro Glu His Ala Val Leu Lys Gln Gly Ser Trp Asn Pro Ala 
145                 150                 155                 160 


Ser Leu His Cys Leu Lys Pro Gly Cys Leu Gln Gly Val Met Val Thr 
                165                 170                 175     


Tyr Gly Gln Glu Met Leu Lys Asn Leu Val Leu Arg Ser Trp Ser Gln 
            180                 185                 190         


Arg Ser Ser Trp Arg Met Leu Ile Ala Met Gln Gln Asp Pro 
        195                 200                 205     


<210>  4893
<211>  206
<212>  PRT
<213>  Homo Sapiens

<400>  4893

Met Ala Gln Leu Gly Ala Val Val Ala Val Ala Ser Ser Phe Phe Cys 
1               5                   10                  15      


Ala Ser Leu Phe Ser Ala Val His Lys Ile Glu Glu Gly His Ile Gly 
            20                  25                  30          


Val Tyr Tyr Arg Gly Gly Ala Leu Leu Thr Ser Thr Ser Gly Pro Gly 
        35                  40                  45              


Phe His Leu Met Leu Pro Phe Ile Thr Ser Tyr Lys Ser Val Gln Thr 
    50                  55                  60                  


Thr Leu Gln Thr Asp Glu Val Lys Asn Val Pro Cys Gly Thr Ser Gly 
65                  70                  75                  80  


Gly Val Met Ile Tyr Phe Asp Arg Ile Glu Val Val Asn Phe Leu Val 
                85                  90                  95      


Pro Asn Ala Val Tyr Asp Ile Val Lys Asn Tyr Thr Ala Asp Tyr Asp 
            100                 105                 110         


Lys Ala Leu Ile Phe Asn Lys Ile His His Glu Leu Asn Gln Phe Cys 
        115                 120                 125             


Ser Val His Thr Leu Gln Glu Val Tyr Ile Glu Leu Phe Gly Lys Lys 
    130                 135                 140                 


Val Ser Pro Glu His Ala Val Leu Lys Gln Gly Ser Trp Asn Pro Ala 
145                 150                 155                 160 


Ser Leu His Cys Leu Lys Pro Gly Cys Leu Gln Gly Val Met Val Thr 
                165                 170                 175     


Tyr Gly Gln Glu Met Leu Lys Asn Leu Val Leu Arg Ser Trp Ser Gln 
            180                 185                 190         


Arg Ser Ser Trp Arg Met Leu Ile Ala Met Gln Gln Asp Pro 
        195                 200                 205     


<210>  4894
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  4894

Met Ala Gln Leu Gly Ala Val Val Ala Val Ala Ser Ser Phe Phe Cys 
1               5                   10                  15      


Ala Ser Leu Phe Ser Ala Val His Lys Ile Glu Glu Gly His Ile Gly 
            20                  25                  30          


Val Tyr Tyr Arg Gly Gly Ala Leu Leu Thr Ser Thr Ser Gly Pro Gly 
        35                  40                  45              


Phe His Leu Met Leu Pro Phe Ile Thr Ser Tyr Lys Ser Val Gln Thr 
    50                  55                  60                  


Thr Leu Gln Thr Asp Glu Val Lys Asn Val Pro Cys Gly Thr Ser Gly 
65                  70                  75                  80  


Gly Val Met Ile Tyr Phe Asp Arg Ile Glu Val Val Asn Phe Leu Val 
                85                  90                  95      


Pro Asn Ala Val Tyr Asp Ile Val Lys Asn Tyr Thr Ala Asp Tyr Asp 
            100                 105                 110         


Lys Ala Leu Ile Phe Asn Lys Ile His His Glu Leu Asn Gln Phe Cys 
        115                 120                 125             


Ser Val His Thr Leu Gln Glu Val Tyr Ile Glu Leu Phe Gly Leu Glu 
    130                 135                 140                 


Asn Asp Phe Ser Gln Glu Ser Ser 
145                 150         


<210>  4895
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  4895

Met Ala Gln Leu Gly Ala Val Val Ala Val Ala Ser Ser Phe Phe Cys 
1               5                   10                  15      


Ala Ser Leu Phe Ser Ala Val His Lys Ile Glu Glu Gly His Ile Gly 
            20                  25                  30          


Val Tyr Tyr Arg Gly Gly Ala Leu Leu Thr Ser Thr Ser Gly Pro Gly 
        35                  40                  45              


Phe His Leu Met Leu Pro Phe Ile Thr Ser Tyr Lys Ser Val Gln Thr 
    50                  55                  60                  


Thr Leu Gln Thr Asp Glu Val Lys Asn Val Pro Cys Gly Thr Ser Gly 
65                  70                  75                  80  


Gly Val Met Ile Tyr Phe Asp Arg Ile Glu Val Val Asn Phe Leu Val 
                85                  90                  95      


Pro Asn Ala Val Tyr Asp Ile Val Lys Asn Tyr Thr Ala Asp Tyr Asp 
            100                 105                 110         


Lys Ala Leu Ile Phe Asn Lys Ile His His Glu Leu Asn Gln Phe Cys 
        115                 120                 125             


Ser Val His Thr Leu Gln Glu Val Tyr Ile Glu Leu Phe Gly Leu Glu 
    130                 135                 140                 


Asn Asp Phe Ser Gln Glu Ser Ser 
145                 150         


<210>  4896
<211>  197
<212>  PRT
<213>  Homo Sapiens

<400>  4896

Met Ala Gln Leu Gly Ala Val Val Ala Val Ala Ser Ser Phe Phe Cys 
1               5                   10                  15      


Ala Ser Leu Phe Ser Ala Val His Lys Ile Glu Glu Gly His Ile Gly 
            20                  25                  30          


Val Tyr Tyr Ser Gly Gly Val Met Ile Tyr Phe Asp Arg Ile Glu Val 
        35                  40                  45              


Val Asn Phe Leu Val Pro Asn Ala Val Tyr Asp Ile Val Lys Asn Tyr 
    50                  55                  60                  


Thr Ala Asp Tyr Asp Lys Ala Leu Ile Phe Asn Lys Ile His His Glu 
65                  70                  75                  80  


Leu Asn Gln Phe Cys Ser Val His Thr Leu Gln Glu Val Tyr Ile Glu 
                85                  90                  95      


Leu Phe Asp Gln Ile Asp Glu Asn Leu Lys Leu Ala Leu Gln Gln Asp 
            100                 105                 110         


Leu Thr Ser Met Ala Pro Gly Leu Val Ile Gln Ala Val Arg Val Thr 
        115                 120                 125             


Lys Pro Asn Ile Pro Glu Ala Ile Arg Arg Asn Tyr Glu Leu Met Glu 
    130                 135                 140                 


Ser Glu Lys Thr Lys Leu Leu Ile Ala Ala Gln Lys Gln Lys Val Val 
145                 150                 155                 160 


Glu Lys Glu Ala Glu Thr Glu Arg Lys Lys Ala Leu Ile Glu Ala Glu 
                165                 170                 175     


Lys Val Ala Gln Val Ala Glu Ile Thr Tyr Gly Gln Lys Val Met Glu 
            180                 185                 190         


Lys Glu Thr Glu Lys 
        195         


<210>  4897
<211>  977
<212>  PRT
<213>  Homo Sapiens

<400>  4897

Met Pro Ala Arg Arg Leu Leu Leu Leu Leu Thr Leu Leu Leu Pro Gly 
1               5                   10                  15      


Leu Gly Ile Phe Gly Ser Thr Ser Thr Val Thr Leu Pro Glu Thr Leu 
            20                  25                  30          


Leu Phe Val Ser Thr Leu Asp Gly Ser Leu His Ala Val Ser Lys Arg 
        35                  40                  45              


Thr Gly Ser Ile Lys Trp Thr Leu Lys Glu Asp Pro Val Leu Gln Val 
    50                  55                  60                  


Pro Thr His Val Glu Glu Pro Ala Phe Leu Pro Asp Pro Asn Asp Gly 
65                  70                  75                  80  


Ser Leu Tyr Thr Leu Gly Ser Lys Asn Asn Glu Gly Leu Thr Lys Leu 
                85                  90                  95      


Pro Phe Thr Ile Pro Glu Leu Val Gln Ala Ser Pro Cys Arg Ser Ser 
            100                 105                 110         


Asp Gly Ile Leu Tyr Met Gly Lys Lys Gln Asp Ile Trp Tyr Val Ile 
        115                 120                 125             


Asp Leu Leu Thr Gly Glu Lys Gln Gln Thr Leu Ser Ser Ala Phe Ala 
    130                 135                 140                 


Asp Ser Leu Cys Pro Ser Thr Ser Leu Leu Tyr Leu Gly Arg Thr Glu 
145                 150                 155                 160 


Tyr Thr Ile Thr Met Tyr Asp Thr Lys Thr Arg Glu Leu Arg Trp Asn 
                165                 170                 175     


Ala Thr Tyr Phe Asp Tyr Ala Ala Ser Leu Pro Glu Asp Asp Val Asp 
            180                 185                 190         


Tyr Lys Met Ser His Phe Val Ser Asn Gly Asp Gly Leu Val Val Thr 
        195                 200                 205             


Val Asp Ser Glu Ser Gly Asp Val Leu Trp Ile Gln Asn Tyr Ala Ser 
    210                 215                 220                 


Pro Val Val Ala Phe Tyr Val Trp Gln Arg Glu Gly Leu Arg Lys Val 
225                 230                 235                 240 


Met His Ile Asn Val Ala Val Glu Thr Leu Arg Tyr Leu Thr Phe Met 
                245                 250                 255     


Ser Gly Glu Val Gly Arg Ile Thr Lys Trp Lys Tyr Pro Phe Pro Lys 
            260                 265                 270         


Glu Thr Glu Ala Lys Ser Lys Leu Thr Pro Thr Leu Tyr Val Gly Lys 
        275                 280                 285             


Tyr Ser Thr Ser Leu Tyr Ala Ser Pro Ser Met Val His Glu Gly Val 
    290                 295                 300                 


Ala Val Val Pro Arg Gly Ser Thr Leu Pro Leu Leu Glu Gly Pro Gln 
305                 310                 315                 320 


Thr Asp Gly Val Thr Ile Gly Asp Lys Gly Glu Cys Val Ile Thr Pro 
                325                 330                 335     


Ser Thr Asp Val Lys Phe Asp Pro Gly Leu Lys Ser Lys Asn Lys Leu 
            340                 345                 350         


Asn Tyr Leu Arg Asn Tyr Trp Leu Leu Ile Gly His His Glu Thr Pro 
        355                 360                 365             


Leu Ser Ala Ser Thr Lys Met Leu Glu Arg Phe Pro Asn Asn Leu Pro 
    370                 375                 380                 


Lys His Arg Glu Asn Val Ile Pro Ala Asp Ser Glu Lys Lys Ser Phe 
385                 390                 395                 400 


Glu Glu Val Ile Asn Leu Val Asp Gln Thr Ser Glu Asn Ala Pro Thr 
                405                 410                 415     


Thr Val Ser Arg Asp Val Glu Glu Lys Pro Ala His Ala Pro Ala Arg 
            420                 425                 430         


Pro Glu Ala Pro Val Asp Ser Met Leu Lys Asp Met Ala Thr Ile Ile 
        435                 440                 445             


Leu Ser Thr Phe Leu Leu Ile Gly Trp Val Ala Phe Ile Ile Thr Tyr 
    450                 455                 460                 


Pro Leu Ser Met His Gln Gln Gln Gln Leu Gln His Gln Gln Phe Gln 
465                 470                 475                 480 


Lys Glu Leu Glu Lys Ile Gln Leu Leu Gln Gln Gln Gln Gln Gln Leu 
                485                 490                 495     


Pro Phe His Pro Pro Gly Asp Thr Ala Gln Asp Gly Glu Leu Leu Asp 
            500                 505                 510         


Thr Ser Gly Pro Tyr Ser Glu Ser Ser Gly Thr Ser Ser Pro Ser Thr 
        515                 520                 525             


Ser Pro Arg Ala Ser Asn His Ser Leu Cys Ser Gly Ser Ser Ala Ser 
    530                 535                 540                 


Lys Ala Gly Ser Ser Pro Ser Leu Glu Gln Asp Asp Gly Asp Glu Glu 
545                 550                 555                 560 


Thr Ser Val Val Ile Val Gly Lys Ile Ser Phe Cys Pro Lys Asp Val 
                565                 570                 575     


Leu Gly His Gly Ala Glu Gly Thr Ile Val Tyr Arg Gly Met Phe Asp 
            580                 585                 590         


Asn Arg Asp Val Ala Val Lys Arg Ile Leu Pro Glu Cys Phe Ser Phe 
        595                 600                 605             


Ala Asp Arg Glu Val Gln Leu Leu Arg Glu Ser Asp Glu His Pro Asn 
    610                 615                 620                 


Val Ile Arg Tyr Phe Cys Thr Glu Lys Asp Arg Gln Phe Gln Tyr Ile 
625                 630                 635                 640 


Ala Ile Glu Leu Cys Ala Ala Thr Leu Gln Glu Tyr Val Glu Gln Lys 
                645                 650                 655     


Asp Phe Ala His Leu Gly Leu Glu Pro Ile Thr Leu Leu Gln Gln Thr 
            660                 665                 670         


Thr Ser Gly Leu Ala His Leu His Ser Leu Asn Ile Val His Arg Asp 
        675                 680                 685             


Leu Lys Pro His Asn Ile Leu Ile Ser Met Pro Asn Ala His Gly Lys 
    690                 695                 700                 


Ile Lys Ala Met Ile Ser Asp Phe Gly Leu Cys Lys Lys Leu Ala Val 
705                 710                 715                 720 


Gly Arg His Ser Phe Ser Arg Arg Ser Gly Val Pro Gly Thr Glu Gly 
                725                 730                 735     


Trp Ile Ala Pro Glu Met Leu Ser Glu Asp Cys Lys Glu Asn Pro Thr 
            740                 745                 750         


Tyr Thr Val Asp Ile Phe Ser Ala Gly Cys Val Phe Tyr Tyr Val Ile 
        755                 760                 765             


Ser Glu Gly Ser His Pro Phe Gly Lys Ser Leu Gln Arg Gln Ala Asn 
    770                 775                 780                 


Ile Leu Leu Gly Ala Cys Ser Leu Asp Cys Leu His Pro Glu Lys His 
785                 790                 795                 800 


Glu Asp Val Ile Ala Arg Glu Leu Ile Glu Lys Met Ile Ala Met Asp 
                805                 810                 815     


Pro Gln Lys Arg Pro Ser Ala Lys His Val Leu Lys His Pro Phe Phe 
            820                 825                 830         


Trp Ser Leu Glu Lys Gln Leu Gln Phe Phe Gln Asp Val Ser Asp Arg 
        835                 840                 845             


Ile Glu Lys Glu Ser Leu Asp Gly Pro Ile Val Lys Gln Leu Glu Arg 
    850                 855                 860                 


Gly Gly Arg Ala Val Val Lys Met Asp Trp Arg Glu Asn Ile Thr Val 
865                 870                 875                 880 


Pro Leu Gln Thr Asp Leu Arg Lys Phe Arg Thr Tyr Lys Gly Gly Ser 
                885                 890                 895     


Val Arg Asp Leu Leu Arg Ala Met Arg Asn Lys Lys His His Tyr Arg 
            900                 905                 910         


Glu Leu Pro Ala Glu Val Arg Glu Thr Leu Gly Ser Leu Pro Asp Asp 
        915                 920                 925             


Phe Val Cys Tyr Phe Thr Ser Arg Phe Pro His Leu Leu Ala His Thr 
    930                 935                 940                 


Tyr Arg Ala Met Glu Leu Cys Ser His Glu Arg Leu Phe Gln Pro Tyr 
945                 950                 955                 960 


Tyr Phe His Glu Pro Pro Glu Pro Gln Pro Pro Val Thr Pro Asp Ala 
                965                 970                 975     


Leu 
    


<210>  4898
<211>  70
<212>  PRT
<213>  Homo Sapiens

<400>  4898

Met Pro Ala Arg Arg Leu Leu Leu Leu Leu Thr Leu Leu Leu Pro Gly 
1               5                   10                  15      


Leu Gly Val Ser Asp Arg Gly Ala Trp Gly Gly Gly Gln Leu Ala Thr 
            20                  25                  30          


Ala Gly Ser Gly Pro Gly Gln Arg Arg Gly Ala Gly Ala Gly Val Arg 
        35                  40                  45              


Ala Gly Ser Ala Thr Ala Ala Ala Arg Cys Pro Val Ser Pro Ala Val 
    50                  55                  60                  


Gly Gly Ser Gly Arg Ala 
65                  70  


<210>  4899
<211>  23
<212>  PRT
<213>  Homo Sapiens

<400>  4899

Glu Leu Leu Gln Leu Leu Pro Pro Asp Ser Pro Thr Arg Trp Leu Pro 
1               5                   10                  15      


Gly Thr Trp Leu Glu Pro Cys 
            20              


<210>  4900
<211>  80
<212>  PRT
<213>  Homo Sapiens

<400>  4900

Met Ala Ser Ala Val Arg Gly Ser Arg Pro Trp Pro Arg Leu Gly Leu 
1               5                   10                  15      


Gln Leu Gln Phe Ala Ala Leu Leu Leu Gly Thr Leu Ser Pro Gln Gly 
            20                  25                  30          


Cys Gly Trp Ala Thr Arg Met Leu Gly Leu Leu Leu Gly Ala Gln Pro 
        35                  40                  45              


His Pro Val Cys Ser Arg Arg Asp Trp Ser Arg Phe Ile Leu Ser Gly 
    50                  55                  60                  


Gln Arg Thr Ser Cys Trp Cys Pro Pro Trp Met Glu Val Ser Thr His 
65                  70                  75                  80  


<210>  4901
<211>  129
<212>  PRT
<213>  Homo Sapiens

<400>  4901

Met Ala Ser Ala Val Arg Gly Ser Arg Pro Trp Pro Arg Leu Gly Leu 
1               5                   10                  15      


Gln Leu Gln Phe Ala Ala Leu Leu Leu Gly Thr Leu Ser Pro Gln Val 
            20                  25                  30          


His Thr Leu Arg Pro Glu Asn Leu Leu Leu Val Ser Thr Leu Asp Gly 
        35                  40                  45              


Ser Leu His Ala Leu Ser Lys Gln Thr Gly Asp Leu Lys Trp Thr Leu 
    50                  55                  60                  


Arg Asp Asp Pro Val Ile Glu Gly Pro Met Tyr Val Thr Glu Met Ala 
65                  70                  75                  80  


Phe Leu Ser Asp Pro Ala Asp Gly Ser Leu Tyr Ile Leu Gly Thr Gln 
                85                  90                  95      


Lys Gln Gln Gly Leu Met Ala Gly Val Gln Trp Tyr Asp His Lys Ala 
            100                 105                 110         


His Cys Ser Leu Glu Leu Leu Ala Ser Ser Asn Pro Arg Thr Ser Val 
        115                 120                 125             


Ser 
    


<210>  4902
<211>  926
<212>  PRT
<213>  Homo Sapiens

<400>  4902

Met Ala Ser Ala Val Arg Gly Ser Arg Pro Trp Pro Arg Leu Gly Leu 
1               5                   10                  15      


Gln Leu Gln Phe Ala Ala Leu Leu Leu Gly Thr Leu Ser Pro Gln Val 
            20                  25                  30          


His Thr Leu Arg Pro Glu Asn Leu Leu Leu Val Ser Thr Leu Asp Gly 
        35                  40                  45              


Ser Leu His Ala Leu Ser Lys Gln Thr Gly Asp Leu Lys Trp Thr Leu 
    50                  55                  60                  


Arg Asp Asp Pro Val Ile Glu Gly Pro Met Tyr Val Thr Glu Met Ala 
65                  70                  75                  80  


Phe Leu Ser Asp Pro Ala Asp Gly Ser Leu Tyr Ile Leu Gly Thr Gln 
                85                  90                  95      


Lys Gln Gln Gly Leu Met Lys Leu Pro Phe Thr Ile Pro Glu Leu Val 
            100                 105                 110         


His Ala Ser Pro Cys Arg Ser Ser Asp Gly Val Phe Tyr Thr Gly Arg 
        115                 120                 125             


Lys Gln Asp Ala Trp Phe Val Val Asp Pro Glu Ser Gly Glu Thr Gln 
    130                 135                 140                 


Met Thr Leu Thr Thr Glu Gly Pro Ser Thr Pro Arg Leu Tyr Ile Gly 
145                 150                 155                 160 


Arg Thr Gln Tyr Thr Val Thr Met His Asp Pro Arg Ala Pro Ala Leu 
                165                 170                 175     


Arg Trp Asn Thr Thr Tyr Arg Arg Tyr Ser Ala Pro Pro Met Asp Gly 
            180                 185                 190         


Ser Pro Gly Lys Tyr Met Ser His Leu Ala Ser Cys Gly Met Gly Leu 
        195                 200                 205             


Leu Leu Thr Val Asp Pro Gly Ser Gly Thr Val Leu Trp Thr Gln Asp 
    210                 215                 220                 


Leu Gly Val Pro Val Met Gly Val Tyr Thr Trp His Gln Asp Gly Leu 
225                 230                 235                 240 


Arg Gln Leu Pro His Leu Thr Leu Ala Arg Asp Thr Leu His Phe Leu 
                245                 250                 255     


Ala Leu Arg Trp Gly His Ile Arg Leu Pro Ala Ser Gly Pro Arg Asp 
            260                 265                 270         


Thr Ala Thr Leu Phe Ser Thr Leu Asp Thr Gln Leu Leu Met Thr Leu 
        275                 280                 285             


Tyr Val Gly Lys Asp Glu Thr Gly Phe Tyr Val Ser Lys Ala Leu Val 
    290                 295                 300                 


His Thr Gly Val Ala Leu Val Pro Arg Gly Leu Thr Leu Ala Pro Ala 
305                 310                 315                 320 


Asp Gly Pro Thr Thr Asp Glu Val Thr Leu Gln Val Ser Gly Glu Arg 
                325                 330                 335     


Glu Gly Ser Pro Ser Thr Ala Val Arg Tyr Pro Ser Gly Ser Val Ala 
            340                 345                 350         


Leu Pro Ser Gln Trp Leu Leu Ile Gly His His Glu Leu Pro Pro Val 
        355                 360                 365             


Leu His Thr Thr Met Leu Arg Val His Pro Thr Leu Gly Ser Gly Thr 
    370                 375                 380                 


Ala Glu Thr Arg Pro Pro Glu Asn Thr Gln Ala Pro Ala Phe Phe Leu 
385                 390                 395                 400 


Glu Leu Leu Ser Leu Ser Arg Glu Lys Leu Trp Asp Ser Glu Leu His 
                405                 410                 415     


Pro Glu Glu Lys Thr Pro Asp Ser Tyr Leu Gly Leu Gly Pro Gln Asp 
            420                 425                 430         


Leu Leu Ala Ala Ser Leu Thr Ala Val Leu Leu Gly Gly Trp Ile Leu 
        435                 440                 445             


Phe Val Met Arg Gln Gln Gln Pro Gln Val Val Glu Lys Gln Gln Glu 
    450                 455                 460                 


Thr Pro Leu Ala Pro Ala Asp Phe Ala His Ile Ser Gln Asp Ala Gln 
465                 470                 475                 480 


Ser Leu His Ser Gly Ala Ser Arg Arg Ser Gln Lys Arg Leu Gln Ser 
                485                 490                 495     


Pro Ser Lys Gln Ala Gln Pro Leu Asp Asp Pro Glu Ala Glu Gln Leu 
            500                 505                 510         


Thr Val Val Gly Lys Ile Ser Phe Asn Pro Lys Asp Val Leu Gly Arg 
        515                 520                 525             


Gly Ala Gly Gly Thr Phe Val Phe Arg Gly Gln Phe Glu Gly Arg Ala 
    530                 535                 540                 


Val Ala Val Lys Arg Leu Leu Arg Glu Cys Phe Gly Leu Val Arg Arg 
545                 550                 555                 560 


Glu Val Gln Leu Leu Gln Glu Ser Asp Arg His Pro Asn Val Leu Arg 
                565                 570                 575     


Tyr Phe Cys Thr Glu Arg Gly Pro Gln Phe His Tyr Ile Ala Leu Glu 
            580                 585                 590         


Leu Cys Arg Ala Ser Leu Gln Glu Tyr Val Glu Asn Pro Asp Leu Asp 
        595                 600                 605             


Arg Gly Gly Leu Glu Pro Glu Val Val Leu Gln Gln Leu Met Ser Gly 
    610                 615                 620                 


Leu Ala His Leu His Ser Leu His Ile Val His Arg Asp Leu Lys Pro 
625                 630                 635                 640 


Gly Asn Ile Leu Ile Thr Gly Pro Asp Ser Gln Gly Leu Gly Arg Val 
                645                 650                 655     


Val Leu Ser Asp Phe Gly Leu Cys Lys Lys Leu Pro Ala Gly Arg Cys 
            660                 665                 670         


Ser Phe Ser Leu His Ser Gly Ile Pro Gly Thr Glu Gly Trp Met Ala 
        675                 680                 685             


Pro Glu Leu Leu Gln Leu Leu Pro Pro Asp Ser Pro Thr Ser Ala Val 
    690                 695                 700                 


Asp Ile Phe Ser Ala Gly Cys Val Phe Tyr Tyr Val Leu Ser Gly Gly 
705                 710                 715                 720 


Ser His Pro Phe Gly Asp Ser Leu Tyr Arg Gln Ala Asn Ile Leu Thr 
                725                 730                 735     


Gly Ala Pro Cys Leu Ala His Leu Glu Glu Glu Val His Asp Lys Val 
            740                 745                 750         


Val Ala Arg Asp Leu Val Gly Ala Met Leu Ser Pro Leu Pro Gln Pro 
        755                 760                 765             


Arg Pro Ser Ala Pro Gln Val Leu Ala His Pro Phe Phe Trp Ser Arg 
    770                 775                 780                 


Ala Lys Gln Leu Gln Phe Phe Gln Asp Val Ser Asp Trp Leu Glu Lys 
785                 790                 795                 800 


Glu Ser Glu Gln Glu Pro Leu Val Arg Ala Leu Glu Ala Gly Gly Cys 
                805                 810                 815     


Ala Val Val Arg Asp Asn Trp His Glu His Ile Ser Met Pro Leu Gln 
            820                 825                 830         


Thr Asp Leu Arg Lys Phe Arg Ser Tyr Lys Gly Thr Ser Val Arg Asp 
        835                 840                 845             


Leu Leu Arg Ala Val Arg Asn Lys Lys His His Tyr Arg Glu Leu Pro 
    850                 855                 860                 


Val Glu Val Arg Gln Ala Leu Gly Gln Val Pro Asp Gly Phe Val Gln 
865                 870                 875                 880 


Tyr Phe Thr Asn Arg Phe Pro Arg Leu Leu Leu His Thr His Arg Ala 
                885                 890                 895     


Met Arg Ser Cys Ala Ser Glu Ser Leu Phe Leu Pro Tyr Tyr Pro Pro 
            900                 905                 910         


Asp Ser Glu Ala Arg Arg Pro Cys Pro Gly Ala Thr Gly Arg 
        915                 920                 925     


<210>  4903
<211>  874
<212>  PRT
<213>  Homo Sapiens

<400>  4903

Met Ala Ser Ala Val Arg Gly Ser Arg Pro Trp Pro Arg Leu Gly Leu 
1               5                   10                  15      


Gln Leu Gln Phe Ala Ala Leu Leu Leu Gly Thr Leu Ser Pro Gln Val 
            20                  25                  30          


His Thr Leu Arg Pro Glu Asn Leu Leu Leu Val Ser Thr Leu Asp Gly 
        35                  40                  45              


Ser Leu His Ala Leu Ser Lys Gln Thr Gly Asp Leu Lys Trp Thr Leu 
    50                  55                  60                  


Arg Asp Asp Pro Val Ile Glu Gly Pro Met Tyr Val Thr Glu Met Ala 
65                  70                  75                  80  


Phe Leu Ser Asp Pro Ala Asp Gly Ser Leu Tyr Ile Leu Gly Thr Gln 
                85                  90                  95      


Lys Gln Gln Gly Leu Met Lys Leu Pro Phe Thr Ile Pro Glu Leu Val 
            100                 105                 110         


His Ala Ser Pro Cys Arg Ser Ser Asp Gly Val Phe Tyr Thr Gly Arg 
        115                 120                 125             


Lys Gln Asp Ala Trp Phe Val Val Asp Pro Glu Ser Gly Glu Thr Gln 
    130                 135                 140                 


Met Thr Leu Thr Thr Glu Gly Pro Ser Thr Pro Arg Leu Tyr Ile Gly 
145                 150                 155                 160 


Arg Thr Gln Tyr Thr Val Thr Met His Asp Pro Arg Ala Pro Ala Leu 
                165                 170                 175     


Arg Trp Asn Thr Thr Tyr Arg Arg Tyr Ser Ala Pro Pro Met Asp Gly 
            180                 185                 190         


Ser Pro Gly Lys Tyr Met Ser His Leu Ala Ser Cys Gly Met Gly Leu 
        195                 200                 205             


Leu Leu Thr Val Asp Pro Gly Ser Gly Thr Val Leu Trp Thr Gln Asp 
    210                 215                 220                 


Leu Gly Val Pro Val Met Gly Val Tyr Thr Trp His Gln Asp Gly Leu 
225                 230                 235                 240 


Arg Gln Leu Pro His Leu Thr Leu Ala Arg Asp Thr Leu His Phe Leu 
                245                 250                 255     


Ala Leu Arg Trp Gly His Ile Arg Leu Pro Ala Ser Gly Pro Arg Asp 
            260                 265                 270         


Thr Ala Thr Leu Phe Ser Thr Leu Asp Thr Gln Leu Leu Met Thr Leu 
        275                 280                 285             


Tyr Val Gly Lys Asp Glu Thr Gly Phe Tyr Val Ser Lys Ala Leu Val 
    290                 295                 300                 


His Thr Gly Val Ala Leu Val Pro Arg Gly Leu Thr Leu Ala Pro Ala 
305                 310                 315                 320 


Asp Gly Pro Thr Thr Asp Glu Val Thr Leu Gln Val Ser Gly Glu Arg 
                325                 330                 335     


Glu Gly Ser Pro Ser Thr Ala Val Arg Tyr Pro Ser Gly Ser Val Ala 
            340                 345                 350         


Leu Pro Ser Gln Trp Leu Leu Ile Gly His His Glu Leu Pro Pro Val 
        355                 360                 365             


Leu His Thr Thr Met Leu Arg Val His Pro Thr Leu Gly Ser Gly Thr 
    370                 375                 380                 


Ala Glu Thr Arg Pro Pro Glu Asn Thr Gln Ala Pro Ala Phe Phe Leu 
385                 390                 395                 400 


Glu Gln Gln Pro Gln Val Val Glu Lys Gln Gln Glu Thr Pro Leu Ala 
                405                 410                 415     


Pro Ala Asp Phe Ala His Ile Ser Gln Asp Ala Gln Ser Leu His Ser 
            420                 425                 430         


Gly Ala Ser Arg Arg Ser Gln Lys Arg Leu Gln Ser Pro Ser Lys Gln 
        435                 440                 445             


Ala Gln Pro Leu Asp Asp Pro Glu Ala Glu Gln Leu Thr Val Val Gly 
    450                 455                 460                 


Lys Ile Ser Phe Asn Pro Lys Asp Val Leu Gly Arg Gly Ala Gly Gly 
465                 470                 475                 480 


Thr Phe Val Phe Arg Gly Gln Phe Glu Gly Arg Ala Val Ala Val Lys 
                485                 490                 495     


Arg Leu Leu Arg Glu Cys Phe Gly Leu Val Arg Arg Glu Val Gln Leu 
            500                 505                 510         


Leu Gln Glu Ser Asp Arg His Pro Asn Val Leu Arg Tyr Phe Cys Thr 
        515                 520                 525             


Glu Arg Gly Pro Gln Phe His Tyr Ile Ala Leu Glu Leu Cys Arg Ala 
    530                 535                 540                 


Ser Leu Gln Glu Tyr Val Glu Asn Pro Asp Leu Asp Arg Gly Gly Leu 
545                 550                 555                 560 


Glu Pro Glu Val Val Leu Gln Gln Leu Met Ser Gly Leu Ala His Leu 
                565                 570                 575     


His Ser Leu His Ile Val His Arg Asp Leu Lys Pro Gly Asn Ile Leu 
            580                 585                 590         


Ile Thr Gly Pro Asp Ser Gln Gly Leu Gly Arg Val Val Leu Ser Asp 
        595                 600                 605             


Phe Gly Leu Cys Lys Lys Leu Pro Ala Gly Arg Cys Ser Phe Ser Leu 
    610                 615                 620                 


His Ser Gly Ile Pro Gly Thr Glu Gly Trp Met Ala Pro Glu Leu Leu 
625                 630                 635                 640 


Gln Leu Leu Pro Pro Asp Ser Pro Thr Ser Ala Val Asp Ile Phe Ser 
                645                 650                 655     


Ala Gly Cys Val Phe Tyr Tyr Val Leu Ser Gly Gly Ser His Pro Phe 
            660                 665                 670         


Gly Asp Ser Leu Tyr Arg Gln Ala Asn Ile Leu Thr Gly Ala Pro Cys 
        675                 680                 685             


Leu Ala His Leu Glu Glu Glu Val His Asp Lys Val Val Ala Arg Asp 
    690                 695                 700                 


Leu Val Gly Ala Met Leu Ser Pro Leu Pro Gln Pro Arg Pro Ser Ala 
705                 710                 715                 720 


Pro Gln Val Leu Ala His Pro Phe Phe Trp Ser Arg Ala Lys Gln Leu 
                725                 730                 735     


Gln Phe Phe Gln Asp Val Ser Asp Trp Leu Glu Lys Glu Ser Glu Gln 
            740                 745                 750         


Glu Pro Leu Val Arg Ala Leu Glu Ala Gly Gly Cys Ala Val Val Arg 
        755                 760                 765             


Asp Asn Trp His Glu His Ile Ser Met Pro Leu Gln Thr Asp Leu Arg 
    770                 775                 780                 


Lys Phe Arg Ser Tyr Lys Gly Thr Ser Val Arg Asp Leu Leu Arg Ala 
785                 790                 795                 800 


Val Arg Asn Lys Lys His His Tyr Arg Glu Leu Pro Val Glu Val Arg 
                805                 810                 815     


Gln Ala Leu Gly Gln Val Pro Asp Gly Phe Val Gln Tyr Phe Thr Asn 
            820                 825                 830         


Arg Phe Pro Arg Leu Leu Leu His Thr His Arg Ala Met Arg Ser Cys 
        835                 840                 845             


Ala Ser Glu Ser Leu Phe Leu Pro Tyr Tyr Pro Pro Asp Ser Glu Ala 
    850                 855                 860                 


Arg Arg Pro Cys Pro Gly Ala Thr Gly Arg 
865                 870                 


<210>  4904
<211>  169
<212>  PRT
<213>  Homo Sapiens

<400>  4904

Met Gly Arg Gly Trp Gly Phe Leu Phe Gly Leu Leu Gly Ala Val Trp 
1               5                   10                  15      


Leu Leu Ser Ser Gly His Gly Glu Glu Gln Pro Pro Glu Thr Ala Ala 
            20                  25                  30          


Gln Arg Cys Phe Cys Gln Val Asn Leu Lys Arg Pro Cys Pro Phe Trp 
        35                  40                  45              


Asn Asp Ile Ser Gln Cys Gly Arg Arg Asp Cys Ala Val Lys Pro Cys 
    50                  55                  60                  


Gln Ser Asp Glu Val Pro Asp Gly Ile Lys Ser Ala Ser Tyr Lys Tyr 
65                  70                  75                  80  


Ser Glu Glu Ala Asn Asn Leu Ile Glu Glu Cys Glu Gln Ala Glu Arg 
                85                  90                  95      


Leu Gly Ala Val Asp Glu Ser Leu Ser Glu Glu Thr Gln Lys Ala Val 
            100                 105                 110         


Leu Gln Trp Thr Lys His Asp Asp Ser Ser Asp Asn Phe Cys Glu Ala 
        115                 120                 125             


Asp Asp Ile Gln Ser Pro Glu Ala Glu Tyr Val Asp Leu Leu Leu Asn 
    130                 135                 140                 


Pro Glu Arg Tyr Thr Gly Tyr Lys Gly Pro Asp Ala Trp Lys Ile Trp 
145                 150                 155                 160 


Asn Val Ile Tyr Glu Glu Asn Cys Phe 
                165                 


<210>  4905
<211>  125
<212>  PRT
<213>  Homo Sapiens

<400>  4905

Met Gly Arg Gly Trp Gly Phe Leu Phe Gly Leu Leu Gly Ala Val Trp 
1               5                   10                  15      


Leu Leu Ser Ser Gly His Gly Glu Glu Gln Pro Pro Glu Thr Ala Ala 
            20                  25                  30          


Gln Arg Cys Phe Cys Gln Val Ser Gly Tyr Leu Asp Asp Cys Thr Cys 
        35                  40                  45              


Asp Val Glu Thr Ile Asp Arg Phe Asn Asn Tyr Arg Leu Phe Pro Arg 
    50                  55                  60                  


Leu Gln Lys Leu Leu Glu Ser Asp Tyr Phe Arg Tyr Tyr Lys Val Asn 
65                  70                  75                  80  


Leu Lys Arg Pro Cys Pro Phe Trp Asn Asp Ile Ser Gln Cys Gly Arg 
                85                  90                  95      


Arg Asp Cys Ala Val Lys Pro Cys Gln Ser Asp Glu Val Pro Asp Gly 
            100                 105                 110         


Ile Lys Ser Ala Ser Tyr Lys Val Cys Thr Tyr Thr Tyr 
        115                 120                 125 


<210>  4906
<211>  257
<212>  PRT
<213>  Homo Sapiens

<400>  4906

Met Gly Arg Gly Trp Gly Phe Leu Phe Gly Leu Leu Gly Ala Val Trp 
1               5                   10                  15      


Leu Leu Ser Ser Gly His Gly Glu Glu Gln Pro Pro Glu Thr Ala Ala 
            20                  25                  30          


Gln Arg Cys Phe Cys Gln Val Ser Gly Tyr Leu Asp Asp Cys Thr Cys 
        35                  40                  45              


Asp Val Glu Thr Ile Asp Arg Phe Asn Asn Tyr Arg Leu Phe Pro Arg 
    50                  55                  60                  


Leu Gln Lys Leu Leu Glu Ser Asp Tyr Phe Arg Tyr Tyr Lys Val Asn 
65                  70                  75                  80  


Leu Lys Arg Pro Cys Pro Phe Trp Asn Asp Ile Ser Gln Cys Gly Arg 
                85                  90                  95      


Arg Asp Cys Ala Val Lys Pro Cys Gln Ser Asp Glu Val Pro Asp Gly 
            100                 105                 110         


Ile Lys Ser Ala Ser Tyr Lys Tyr Ser Glu Glu Ala Asn Asn Leu Ile 
        115                 120                 125             


Glu Glu Cys Glu Gln Ala Glu Arg Leu Gly Ala Val Asp Glu Ser Leu 
    130                 135                 140                 


Ser Glu Glu Thr Gln Lys Ala Val Leu Gln Trp Thr Lys His Asp Asp 
145                 150                 155                 160 


Ser Ser Asp Asn Phe Cys Glu Ala Asp Asp Ile Gln Ser Pro Glu Ala 
                165                 170                 175     


Glu Tyr Val Asp Leu Leu Leu Asn Pro Glu Arg Tyr Thr Gly Tyr Lys 
            180                 185                 190         


Gly Pro Asp Ala Trp Lys Ile Trp Asn Val Ile Tyr Glu Glu Asn Cys 
        195                 200                 205             


Phe Lys Pro Gln Thr Ile Lys Arg Pro Leu Asn Pro Leu Ala Ser Gly 
    210                 215                 220                 


Gln Gly Lys Leu Leu Ile Cys Val Ser Leu Leu Phe Leu Arg Ser Leu 
225                 230                 235                 240 


Cys Arg Lys Lys Ser Ile Leu Gln Thr Tyr Ile Trp Pro Thr Cys Lys 
                245                 250                 255     


His 
    


<210>  4907
<211>  257
<212>  PRT
<213>  Homo Sapiens

<400>  4907

Met Gly Arg Gly Trp Gly Phe Leu Phe Gly Leu Leu Gly Ala Val Trp 
1               5                   10                  15      


Leu Leu Ser Ser Gly His Gly Glu Glu Gln Pro Pro Glu Thr Ala Ala 
            20                  25                  30          


Gln Arg Cys Phe Cys Gln Val Ser Gly Tyr Leu Asp Asp Cys Thr Cys 
        35                  40                  45              


Asp Val Glu Thr Ile Asp Arg Phe Asn Asn Tyr Arg Leu Phe Pro Arg 
    50                  55                  60                  


Leu Gln Lys Leu Leu Glu Ser Asp Tyr Phe Arg Tyr Tyr Lys Val Asn 
65                  70                  75                  80  


Leu Lys Arg Pro Cys Pro Phe Trp Asn Asp Ile Ser Gln Cys Gly Arg 
                85                  90                  95      


Arg Asp Cys Ala Val Lys Pro Cys Gln Ser Asp Glu Val Pro Asp Gly 
            100                 105                 110         


Ile Lys Ser Ala Ser Tyr Lys Tyr Ser Glu Glu Ala Asn Asn Leu Ile 
        115                 120                 125             


Glu Glu Cys Glu Gln Ala Glu Arg Leu Gly Ala Val Asp Glu Ser Leu 
    130                 135                 140                 


Ser Glu Glu Thr Gln Lys Ala Val Leu Gln Trp Thr Lys His Asp Asp 
145                 150                 155                 160 


Ser Ser Asp Asn Phe Cys Glu Ala Asp Asp Ile Gln Ser Pro Glu Ala 
                165                 170                 175     


Glu Tyr Val Asp Leu Leu Leu Asn Pro Glu Arg Tyr Thr Gly Tyr Lys 
            180                 185                 190         


Gly Pro Asp Ala Trp Lys Ile Trp Asn Val Ile Tyr Glu Glu Asn Cys 
        195                 200                 205             


Phe Lys Pro Gln Thr Ile Lys Arg Pro Leu Asn Pro Leu Ala Ser Gly 
    210                 215                 220                 


Gln Gly Lys Leu Leu Ile Cys Val Ser Leu Leu Phe Leu Arg Ser Leu 
225                 230                 235                 240 


Cys Arg Lys Lys Ser Ile Leu Gln Thr Tyr Ile Trp Pro Thr Cys Lys 
                245                 250                 255     


His 
    


<210>  4908
<211>  257
<212>  PRT
<213>  Homo Sapiens

<400>  4908

Met Gly Arg Gly Trp Gly Phe Leu Phe Gly Leu Leu Gly Ala Val Trp 
1               5                   10                  15      


Leu Leu Ser Ser Gly His Gly Glu Glu Gln Pro Pro Glu Thr Ala Ala 
            20                  25                  30          


Gln Arg Cys Phe Cys Gln Val Ser Gly Tyr Leu Asp Asp Cys Thr Cys 
        35                  40                  45              


Asp Val Glu Thr Ile Asp Arg Phe Asn Asn Tyr Arg Leu Phe Pro Arg 
    50                  55                  60                  


Leu Gln Lys Leu Leu Glu Ser Asp Tyr Phe Arg Tyr Tyr Lys Val Asn 
65                  70                  75                  80  


Leu Lys Arg Pro Cys Pro Phe Trp Asn Asp Ile Ser Gln Cys Gly Arg 
                85                  90                  95      


Arg Asp Cys Ala Val Lys Pro Cys Gln Ser Asp Glu Val Pro Asp Gly 
            100                 105                 110         


Ile Lys Ser Ala Ser Tyr Lys Tyr Ser Glu Glu Ala Asn Asn Leu Ile 
        115                 120                 125             


Glu Glu Cys Glu Gln Ala Glu Arg Leu Gly Ala Val Asp Glu Ser Leu 
    130                 135                 140                 


Ser Glu Glu Thr Gln Lys Ala Val Leu Gln Trp Thr Lys His Asp Asp 
145                 150                 155                 160 


Ser Ser Asp Asn Phe Cys Glu Ala Asp Asp Ile Gln Ser Pro Glu Ala 
                165                 170                 175     


Glu Tyr Val Asp Leu Leu Leu Asn Pro Glu Arg Tyr Thr Gly Tyr Lys 
            180                 185                 190         


Gly Pro Asp Ala Trp Lys Ile Trp Asn Val Ile Tyr Glu Glu Asn Cys 
        195                 200                 205             


Phe Lys Pro Gln Thr Ile Lys Arg Pro Leu Asn Pro Leu Ala Ser Gly 
    210                 215                 220                 


Gln Gly Lys Leu Leu Ile Cys Val Ser Leu Leu Phe Leu Arg Ser Leu 
225                 230                 235                 240 


Cys Arg Lys Lys Ser Ile Leu Gln Thr Tyr Ile Trp Pro Thr Cys Lys 
                245                 250                 255     


His 
    


<210>  4909
<211>  468
<212>  PRT
<213>  Homo Sapiens

<400>  4909

Met Gly Arg Gly Trp Gly Phe Leu Phe Gly Leu Leu Gly Ala Val Trp 
1               5                   10                  15      


Leu Leu Ser Ser Gly His Gly Glu Glu Gln Pro Pro Glu Thr Ala Ala 
            20                  25                  30          


Gln Arg Cys Phe Cys Gln Val Ser Gly Tyr Leu Asp Asp Cys Thr Cys 
        35                  40                  45              


Asp Val Glu Thr Ile Asp Arg Phe Asn Asn Tyr Arg Leu Phe Pro Arg 
    50                  55                  60                  


Leu Gln Lys Leu Leu Glu Ser Asp Tyr Phe Arg Tyr Tyr Lys Val Asn 
65                  70                  75                  80  


Leu Lys Arg Pro Cys Pro Phe Trp Asn Asp Ile Ser Gln Cys Gly Arg 
                85                  90                  95      


Arg Asp Cys Ala Val Lys Pro Cys Gln Ser Asp Glu Val Pro Asp Gly 
            100                 105                 110         


Ile Lys Ser Ala Ser Tyr Lys Tyr Ser Glu Glu Ala Asn Asn Leu Ile 
        115                 120                 125             


Glu Glu Cys Glu Gln Ala Glu Arg Leu Gly Ala Val Asp Glu Ser Leu 
    130                 135                 140                 


Ser Glu Glu Thr Gln Lys Ala Val Leu Gln Trp Thr Lys His Asp Asp 
145                 150                 155                 160 


Ser Ser Asp Asn Phe Cys Glu Ala Asp Asp Ile Gln Ser Pro Glu Ala 
                165                 170                 175     


Glu Tyr Val Asp Leu Leu Leu Asn Pro Glu Arg Tyr Thr Gly Tyr Lys 
            180                 185                 190         


Gly Pro Asp Ala Trp Lys Ile Trp Asn Val Ile Tyr Glu Glu Asn Cys 
        195                 200                 205             


Phe Lys Pro Gln Thr Ile Lys Arg Pro Leu Asn Pro Leu Ala Ser Gly 
    210                 215                 220                 


Gln Gly Thr Ser Glu Glu Asn Thr Phe Tyr Ser Trp Leu Glu Gly Leu 
225                 230                 235                 240 


Cys Val Glu Lys Arg Ala Phe Tyr Arg Leu Ile Ser Gly Leu His Ala 
                245                 250                 255     


Ser Ile Asn Val His Leu Ser Ala Arg Tyr Leu Leu Gln Glu Thr Trp 
            260                 265                 270         


Leu Glu Lys Lys Trp Gly His Asn Ile Thr Glu Phe Gln Gln Arg Phe 
        275                 280                 285             


Asp Gly Ile Leu Thr Glu Gly Glu Gly Pro Arg Arg Leu Lys Asn Leu 
    290                 295                 300                 


Tyr Phe Leu Tyr Leu Ile Glu Leu Arg Ala Leu Ser Lys Val Leu Pro 
305                 310                 315                 320 


Phe Phe Glu Arg Pro Asp Phe Gln Leu Phe Thr Gly Asn Lys Ile Gln 
                325                 330                 335     


Asp Glu Glu Asn Lys Met Leu Leu Leu Glu Ile Leu His Glu Ile Lys 
            340                 345                 350         


Ser Phe Pro Leu His Phe Asp Glu Asn Ser Phe Phe Ala Gly Asp Lys 
        355                 360                 365             


Lys Glu Ala His Lys Leu Lys Glu Asp Phe Arg Leu His Phe Arg Asn 
    370                 375                 380                 


Ile Ser Arg Ile Met Asp Cys Val Gly Cys Phe Lys Cys Arg Leu Trp 
385                 390                 395                 400 


Gly Lys Leu Gln Thr Gln Gly Leu Gly Thr Ala Leu Lys Ile Leu Phe 
                405                 410                 415     


Ser Glu Lys Leu Ile Ala Asn Met Pro Glu Ser Gly Pro Ser Tyr Glu 
            420                 425                 430         


Phe His Leu Thr Arg Gln Glu Ile Val Ser Leu Phe Asn Ala Phe Gly 
        435                 440                 445             


Arg Ile Ser Thr Ser Val Lys Glu Leu Glu Asn Phe Arg Asn Leu Leu 
    450                 455                 460                 


Gln Asn Ile His 
465             


<210>  4910
<211>  75
<212>  PRT
<213>  Homo Sapiens

<400>  4910

Met Leu Leu Leu Glu Ile Leu His Glu Ile Lys Ser Phe Pro Leu His 
1               5                   10                  15      


Phe Asp Glu Asn Ser Phe Phe Ala Gly Asp Lys Lys Glu Ala His Lys 
            20                  25                  30          


Leu Lys Glu Asp Phe Arg Leu His Phe Arg Asn Ile Ser Arg Ile Met 
        35                  40                  45              


Asp Cys Val Gly Cys Phe Lys Cys Arg Leu Trp Gly Lys Leu Gln Thr 
    50                  55                  60                  


Gln Gly Leu Gly Thr Ala Leu Lys Ile Leu Phe 
65                  70                  75  


<210>  4911
<211>  71
<212>  PRT
<213>  Homo Sapiens

<400>  4911

Met Ala Asn Asn Thr Lys Glu Leu Glu Asp Cys Glu Gln Ala Asn Lys 
1               5                   10                  15      


Leu Gly Ala Ile Asn Ser Thr Leu Ser Asn Gln Ser Lys Glu Ala Phe 
            20                  25                  30          


Ile Asp Trp Ala Arg Tyr Asp Asp Ser Arg Asp His Phe Cys Glu Leu 
        35                  40                  45              


Asp Asp Glu Arg Ser Pro Ala Ala Gln Tyr Val Asp Leu Leu Leu Asn 
    50                  55                  60                  


Pro Glu Arg Tyr Thr Gly Tyr 
65                  70      


<210>  4912
<211>  467
<212>  PRT
<213>  Homo Sapiens

<400>  4912

Met Ser Gln Gly Val Arg Arg Ala Gly Ala Gly Gln Gly Val Ala Ala 
1               5                   10                  15      


Ala Val Gln Leu Leu Val Thr Leu Ser Phe Leu Arg Ser Val Val Glu 
            20                  25                  30          


Ala Gln Val Thr Gly Val Leu Asp Asp Cys Leu Cys Asp Ile Asp Ser 
        35                  40                  45              


Ile Asp Asn Phe Asn Thr Tyr Lys Ile Phe Pro Lys Ile Lys Lys Leu 
    50                  55                  60                  


Gln Glu Arg Asp Tyr Phe Arg Tyr Tyr Lys Val Asn Leu Lys Arg Pro 
65                  70                  75                  80  


Cys Pro Phe Trp Ala Glu Asp Gly His Cys Ser Ile Lys Asp Cys His 
                85                  90                  95      


Val Glu Pro Cys Pro Glu Ser Lys Ile Pro Val Gly Ile Lys Ala Gly 
            100                 105                 110         


His Ser Asn Lys Tyr Leu Lys Met Ala Asn Asn Thr Lys Glu Leu Glu 
        115                 120                 125             


Asp Cys Glu Gln Ala Asn Lys Leu Gly Ala Ile Asn Ser Thr Leu Ser 
    130                 135                 140                 


Asn Gln Ser Lys Glu Ala Phe Ile Asp Trp Ala Arg Tyr Asp Asp Ser 
145                 150                 155                 160 


Arg Asp His Phe Cys Glu Leu Asp Asp Glu Arg Ser Pro Ala Ala Gln 
                165                 170                 175     


Tyr Val Asp Leu Leu Leu Asn Pro Glu Arg Tyr Thr Gly Tyr Lys Gly 
            180                 185                 190         


Thr Ser Ala Trp Arg Val Trp Asn Ser Ile Tyr Glu Glu Asn Cys Phe 
        195                 200                 205             


Lys Pro Arg Ser Val Tyr Arg Pro Leu Asn Pro Leu Ala Pro Ser Arg 
    210                 215                 220                 


Gly Glu Asp Asp Gly Glu Ser Phe Tyr Thr Trp Leu Glu Gly Leu Cys 
225                 230                 235                 240 


Leu Glu Lys Arg Val Phe Tyr Lys Leu Ile Ser Gly Leu His Ala Ser 
                245                 250                 255     


Ile Asn Leu His Leu Cys Ala Asn Tyr Leu Leu Glu Glu Thr Trp Gly 
            260                 265                 270         


Lys Pro Ser Trp Gly Pro Asn Ile Lys Glu Phe Lys His Arg Phe Asp 
        275                 280                 285             


Pro Val Glu Thr Lys Gly Glu Gly Pro Arg Arg Leu Lys Asn Leu Tyr 
    290                 295                 300                 


Phe Leu Tyr Leu Ile Glu Leu Arg Ala Leu Ser Lys Val Ala Pro Tyr 
305                 310                 315                 320 


Phe Glu Arg Ser Ile Val Asp Leu Tyr Thr Gly Asn Ala Glu Glu Asp 
                325                 330                 335     


Ala Asp Thr Lys Thr Leu Leu Leu Asn Ile Phe Gln Asp Thr Lys Ser 
            340                 345                 350         


Phe Pro Met His Phe Asp Glu Lys Ser Met Phe Ala Gly Asp Lys Lys 
        355                 360                 365             


Gly Ala Lys Ser Leu Lys Glu Glu Phe Arg Leu His Phe Lys Asn Ile 
    370                 375                 380                 


Ser Arg Ile Met Asp Cys Val Gly Cys Asp Lys Cys Arg Leu Trp Gly 
385                 390                 395                 400 


Lys Leu Gln Thr Gln Gly Leu Gly Thr Ala Leu Lys Ile Leu Phe Ser 
                405                 410                 415     


Glu Lys Glu Ile Gln Lys Leu Pro Glu Asn Ser Pro Ser Lys Gly Phe 
            420                 425                 430         


Gln Leu Thr Arg Gln Glu Ile Val Ala Leu Leu Asn Ala Phe Gly Arg 
        435                 440                 445             


Leu Ser Thr Ser Ile Arg Asp Leu Gln Asn Phe Lys Val Leu Leu Gln 
    450                 455                 460                 


His Ser Arg 
465         


<210>  4913
<211>  173
<212>  PRT
<213>  Homo Sapiens

<400>  4913

Trp Gly Pro Asn Ile Lys Glu Phe Lys His Arg Phe Asp Pro Val Glu 
1               5                   10                  15      


Thr Lys Gly Glu Gly Pro Arg Arg Leu Lys Asn Leu Tyr Phe Leu Tyr 
            20                  25                  30          


Leu Ile Glu Leu Arg Ala Leu Ser Lys Val Ala Pro Tyr Phe Glu Arg 
        35                  40                  45              


Ser Ile Val Asp Leu Tyr Thr Gly Asn Ala Glu Glu Asp Ala Asp Thr 
    50                  55                  60                  


Lys Thr Leu Leu Leu Asn Ile Phe Gln Asp Thr Lys Ser Phe Pro Met 
65                  70                  75                  80  


His Phe Asp Glu Lys Ser Met Phe Ala Gly Asp Lys Lys Gly Ala Lys 
                85                  90                  95      


Ser Leu Lys Glu Glu Phe Arg Leu His Phe Lys Asn Ile Ser Arg Ile 
            100                 105                 110         


Met Asp Cys Val Gly Cys Asp Lys Cys Arg Leu Trp Gly Lys Leu Gln 
        115                 120                 125             


Thr Gln Gly Leu Gly Thr Ala Leu Lys Ile Leu Phe Ser Glu Lys Glu 
    130                 135                 140                 


Ile Gln Lys Leu Pro Glu Asn Ser Pro Ser Lys Gly Phe Gln Leu Thr 
145                 150                 155                 160 


Arg Gln Glu Ile Val Ala Leu Leu Asn Ala Phe Gly Arg 
                165                 170             


<210>  4914
<211>  273
<212>  PRT
<213>  Homo Sapiens

<400>  4914

Met Glu Ala Ala Pro Ser Arg Phe Met Phe Leu Leu Phe Leu Leu Thr 
1               5                   10                  15      


Cys Glu Leu Ala Ala Glu Val Ala Ala Glu Val Glu Lys Ser Ser Asp 
            20                  25                  30          


Gly Pro Gly Ala Ala Gln Glu Pro Thr Trp Leu Thr Asp Val Pro Ala 
        35                  40                  45              


Ala Met Glu Phe Ile Ala Ala Thr Glu Val Ala Val Ile Gly Phe Phe 
    50                  55                  60                  


Gln Asp Leu Glu Ile Pro Ala Val Pro Ile Leu His Ser Met Val Gln 
65                  70                  75                  80  


Lys Phe Pro Gly Val Ser Phe Gly Ile Ser Thr Asp Ser Glu Val Leu 
                85                  90                  95      


Thr His Tyr Asn Ile Thr Gly Asn Thr Ile Cys Leu Phe Arg Leu Val 
            100                 105                 110         


Asp Asn Glu Gln Leu Asn Leu Glu Asp Glu Asp Ile Glu Ser Ile Asp 
        115                 120                 125             


Ala Thr Lys Leu Ser Arg Phe Ile Glu Ile Asn Ser Leu His Met Val 
    130                 135                 140                 


Thr Glu Tyr Asn Pro Val Thr Val Ile Gly Leu Phe Asn Ser Val Ile 
145                 150                 155                 160 


Gln Ile His Leu Leu Leu Ile Met Asn Lys Ala Ser Pro Glu Tyr Glu 
                165                 170                 175     


Glu Asn Met His Arg Tyr Gln Lys Ala Ala Lys Leu Phe Gln Gly Lys 
            180                 185                 190         


Ile Leu Phe Ile Leu Val Asp Ser Gly Met Lys Glu Asn Gly Lys Val 
        195                 200                 205             


Ile Ser Phe Phe Lys Leu Lys Glu Ser Gln Leu Pro Ala Leu Ala Ile 
    210                 215                 220                 


Tyr Gln Thr Leu Asp Asp Glu Trp Asp Thr Leu Pro Thr Ala Glu Val 
225                 230                 235                 240 


Ser Val Glu His Val Gln Asn Phe Cys Asp Gly Phe Leu Ser Gly Lys 
                245                 250                 255     


Leu Leu Lys Glu Asn Arg Glu Ser Glu Gly Lys Thr Pro Lys Val Glu 
            260                 265                 270         


Leu 
    


<210>  4915
<211>  172
<212>  PRT
<213>  Homo Sapiens

<400>  4915

Met Lys Glu Thr Cys Gln Leu Glu Ile Gln Val Asp Asn Glu Gln Leu 
1               5                   10                  15      


Asn Leu Glu Asp Glu Asp Ile Glu Ser Ile Asp Ala Thr Lys Leu Ser 
            20                  25                  30          


Arg Phe Ile Glu Ile Asn Ser Leu His Met Val Thr Glu Tyr Asn Pro 
        35                  40                  45              


Val Thr Val Ile Gly Leu Phe Asn Ser Val Ile Gln Ile His Leu Leu 
    50                  55                  60                  


Leu Ile Met Asn Lys Ala Ser Pro Glu Tyr Glu Glu Asn Met His Arg 
65                  70                  75                  80  


Tyr Gln Lys Ala Ala Lys Leu Phe Gln Gly Lys Ile Leu Phe Ile Leu 
                85                  90                  95      


Val Asp Ser Gly Met Lys Glu Asn Gly Lys Val Ile Ser Phe Phe Lys 
            100                 105                 110         


Leu Lys Glu Ser Gln Leu Pro Ala Leu Ala Ile Tyr Gln Thr Leu Asp 
        115                 120                 125             


Asp Glu Trp Asp Thr Leu Pro Thr Ala Glu Val Ser Val Glu His Val 
    130                 135                 140                 


Gln Asn Phe Cys Asp Gly Phe Leu Ser Gly Lys Leu Leu Lys Glu Asn 
145                 150                 155                 160 


Arg Glu Ser Glu Gly Lys Thr Pro Lys Val Glu Leu 
                165                 170         


<210>  4916
<211>  53
<212>  PRT
<213>  Homo Sapiens

<400>  4916

Met Ala Ala Ala Val Pro Arg Ala Ala Phe Leu Ser Pro Leu Leu Pro 
1               5                   10                  15      


Leu Leu Leu Gly Phe Leu Leu Leu Ser Ala Pro His Gly Gly Ser Gly 
            20                  25                  30          


Leu His Thr Lys Gly Ala Leu Pro Leu Asp Thr Val Thr Phe Tyr Lys 
        35                  40                  45              


Ile Met Val Thr Ser 
    50              


<210>  4917
<211>  261
<212>  PRT
<213>  Homo Sapiens

<400>  4917

Met Ala Ala Ala Val Pro Arg Ala Ala Phe Leu Ser Pro Leu Leu Pro 
1               5                   10                  15      


Leu Leu Leu Gly Phe Leu Leu Leu Ser Ala Pro His Gly Gly Ser Gly 
            20                  25                  30          


Leu His Thr Lys Gly Ala Leu Pro Leu Asp Thr Val Thr Phe Tyr Lys 
        35                  40                  45              


Val Ile Pro Lys Ser Lys Phe Val Leu Val Lys Phe Asp Thr Gln Tyr 
    50                  55                  60                  


Pro Tyr Gly Glu Lys Gln Asp Glu Phe Lys Arg Leu Ala Glu Asn Ser 
65                  70                  75                  80  


Ala Ser Ser Asp Asp Leu Leu Val Ala Glu Val Gly Ile Ser Asp Tyr 
                85                  90                  95      


Gly Asp Lys Leu Asn Met Glu Leu Ser Glu Lys Tyr Lys Leu Asp Lys 
            100                 105                 110         


Glu Ser Tyr Pro Val Phe Tyr Leu Phe Arg Asp Gly Asp Phe Glu Asn 
        115                 120                 125             


Pro Val Pro Tyr Thr Gly Ala Val Lys Val Gly Ala Ile Gln Arg Trp 
    130                 135                 140                 


Leu Lys Gly Gln Gly Val Tyr Leu Gly Met Pro Gly Cys Leu Pro Val 
145                 150                 155                 160 


Tyr Asp Ala Leu Ala Gly Glu Phe Ile Arg Ala Ser Gly Val Glu Ala 
                165                 170                 175     


Arg Gln Ala Leu Leu Lys Gln Gly Gln Asp Asn Leu Ser Ser Val Lys 
            180                 185                 190         


Glu Thr Gln Lys Lys Trp Ala Glu Gln Tyr Leu Lys Ile Met Gly Lys 
        195                 200                 205             


Ile Leu Asp Gln Gly Glu Asp Phe Pro Ala Ser Glu Met Thr Arg Ile 
    210                 215                 220                 


Ala Arg Leu Ile Glu Lys Asn Lys Met Ser Asp Gly Lys Lys Glu Glu 
225                 230                 235                 240 


Leu Gln Lys Ser Leu Asn Ile Leu Thr Ala Phe Gln Lys Lys Gly Ala 
                245                 250                 255     


Glu Lys Glu Glu Leu 
            260     


<210>  4918
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  4918

Met Glu Leu Ser Glu Lys Tyr Lys Leu Asp Lys Glu Ser Tyr Pro Val 
1               5                   10                  15      


Phe Tyr Leu Phe Arg Asp Gly Asp Phe Glu Asn Pro Val Pro Tyr Thr 
            20                  25                  30          


Gly Ala Val Lys Val Gly Ala Ile Gln Arg Trp Leu Lys Gly Gln Gly 
        35                  40                  45              


Val Tyr Leu Gly Met Pro Gly Cys Leu Pro Val Tyr Asp Ala Leu Ala 
    50                  55                  60                  


Gly Glu Phe Ile Arg Ala Ser Gly Val Glu Ala Arg Gln Ala Leu Leu 
65                  70                  75                  80  


Lys Gln Gly Gln Asp Asn Leu Ser Ser Val Lys Glu Thr Gln Lys Lys 
                85                  90                  95      


Trp Ala Glu Gln Tyr Leu Lys Ile Met Gly Lys Ile Leu Asp Gln Gly 
            100                 105                 110         


Glu Asp Phe Pro Ala Ser Glu Met Thr Arg Ile Ala Arg Leu Ile Glu 
        115                 120                 125             


Lys Asn Lys Met Ser Asp Gly Lys Lys Glu Glu Leu Gln Lys Ser Leu 
    130                 135                 140                 


Asn Ile Leu Thr Ala Phe Gln Lys Lys Gly Ala Glu Lys Glu Glu Leu 
145                 150                 155                 160 


<210>  4919
<211>  95
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4919

Xaa Pro Ala Pro His Phe Ser Pro Arg Cys Phe Pro Phe Ser Trp Ala 
1               5                   10                  15      


Ser Cys Ser Ser Pro Leu Arg Met Ala Ala Ala Ala Cys Thr Pro Arg 
            20                  25                  30          


Ala Pro Phe Pro Trp Ile Arg Ser Leu Ser Thr Arg Gly Pro Leu Gly 
        35                  40                  45              


Arg Gly Ile Ser Pro Lys Ser Pro Trp Asn Thr His Leu Leu Ser Ser 
    50                  55                  60                  


Ile Arg Pro Gln Val Ile Pro Lys Ser Lys Phe Val Leu Val Lys Phe 
65                  70                  75                  80  


Asp Thr Gln Tyr Pro Tyr Gly Glu Lys Gln Asp Glu Phe Lys Arg 
                85                  90                  95  


<210>  4920
<211>  406
<212>  PRT
<213>  Homo Sapiens

<400>  4920

Met His Pro Ala Val Phe Leu Ser Leu Pro Asp Leu Arg Cys Ser Leu 
1               5                   10                  15      


Leu Leu Leu Val Thr Trp Val Phe Thr Pro Val Thr Thr Glu Ile Thr 
            20                  25                  30          


Ser Leu Asp Thr Glu Asn Ile Asp Glu Ile Leu Asn Asn Ala Asp Val 
        35                  40                  45              


Ala Leu Val Asn Phe Tyr Ala Asp Trp Cys Arg Phe Ser Gln Met Leu 
    50                  55                  60                  


His Pro Ile Phe Glu Glu Ala Ser Asp Val Ile Lys Glu Glu Phe Pro 
65                  70                  75                  80  


Asn Glu Asn Gln Val Val Phe Ala Arg Val Asp Cys Asp Gln His Ser 
                85                  90                  95      


Asp Ile Ala Gln Arg Tyr Arg Ile Ser Lys Tyr Pro Thr Leu Lys Leu 
            100                 105                 110         


Phe Arg Asn Gly Met Met Met Lys Arg Glu Tyr Arg Gly Gln Arg Ser 
        115                 120                 125             


Val Lys Ala Leu Ala Asp Tyr Ile Arg Gln Gln Lys Ser Asp Pro Ile 
    130                 135                 140                 


Gln Glu Ile Arg Asp Leu Ala Glu Ile Thr Thr Leu Asp Arg Ser Lys 
145                 150                 155                 160 


Arg Asn Ile Ile Gly Tyr Phe Glu Gln Lys Asp Ser Asp Asn Tyr Arg 
                165                 170                 175     


Val Phe Glu Arg Val Ala Asn Ile Leu His Asp Asp Cys Ala Phe Leu 
            180                 185                 190         


Ser Ala Phe Gly Asp Val Ser Lys Pro Glu Arg Tyr Ser Gly Asp Asn 
        195                 200                 205             


Ile Ile Tyr Lys Pro Pro Gly His Ser Ala Pro Asp Met Val Tyr Leu 
    210                 215                 220                 


Gly Ala Met Thr Asn Phe Asp Val Thr Tyr Asn Trp Ile Gln Asp Lys 
225                 230                 235                 240 


Cys Val Pro Leu Val Arg Glu Ile Thr Phe Glu Asn Gly Glu Glu Leu 
                245                 250                 255     


Thr Glu Glu Gly Leu Pro Phe Leu Ile Leu Phe His Met Lys Glu Asp 
            260                 265                 270         


Thr Glu Ser Leu Glu Ile Phe Gln Asn Glu Val Ala Arg Gln Leu Ile 
        275                 280                 285             


Ser Glu Lys Gly Thr Ile Asn Phe Leu His Ala Asp Cys Asp Lys Phe 
    290                 295                 300                 


Arg His Pro Leu Leu His Ile Gln Lys Thr Pro Ala Asp Cys Pro Val 
305                 310                 315                 320 


Ile Ala Ile Asp Ser Phe Arg His Met Tyr Val Phe Gly Asp Phe Lys 
                325                 330                 335     


Asp Val Leu Ile Pro Gly Lys Leu Lys Gln Phe Val Phe Asp Leu His 
            340                 345                 350         


Ser Gly Lys Leu His Arg Glu Phe His His Gly Pro Asp Pro Thr Asp 
        355                 360                 365             


Thr Ala Pro Gly Glu Gln Ala Gln Asp Val Ala Ser Ser Pro Pro Glu 
    370                 375                 380                 


Ser Ser Phe Gln Lys Leu Ala Pro Ser Glu Tyr Arg Tyr Thr Leu Leu 
385                 390                 395                 400 


Arg Asp Arg Asp Glu Leu 
                405     


<210>  4921
<211>  604
<212>  PRT
<213>  Homo Sapiens

<400>  4921

Met Leu Gly Met Asn Met Leu Leu Ile Thr Leu Phe Leu Leu Leu Pro 
1               5                   10                  15      


Leu Ser Met Leu Lys Gly Glu Pro Trp Glu Gly Cys Leu His Cys Thr 
            20                  25                  30          


His Thr Thr Trp Ser Gly Asn Ile Met Thr Lys Thr Leu Leu Tyr His 
        35                  40                  45              


Thr Tyr Tyr Glu Cys Ala Gly Thr Cys Leu Gly Thr Cys Thr His Asn 
    50                  55                  60                  


Gln Thr Thr Tyr Ser Val Cys Asp Pro Gly Arg Gly Gln Pro Tyr Val 
65                  70                  75                  80  


Cys Tyr Asp Pro Lys Ser Ser Pro Gly Thr Trp Phe Glu Ile His Val 
                85                  90                  95      


Gly Ser Lys Glu Gly Asp Leu Leu Asn Gln Thr Lys Val Phe Pro Ser 
            100                 105                 110         


Gly Lys Asp Val Val Ser Leu Tyr Phe Asp Val Cys Gln Ile Val Ser 
        115                 120                 125             


Met Gly Ser Leu Phe Pro Val Ile Phe Ser Ser Met Glu Tyr Tyr Ser 
    130                 135                 140                 


Ser Cys His Lys Asn Arg Tyr Ala His Pro Ala Cys Ser Thr Asp Ser 
145                 150                 155                 160 


Pro Val Thr Thr Cys Trp Asp Cys Thr Thr Trp Ser Thr Asn Gln Gln 
                165                 170                 175     


Ser Leu Gly Pro Ile Met Leu Thr Lys Ile Pro Leu Glu Pro Asp Cys 
            180                 185                 190         


Lys Thr Ser Thr Cys Asn Ser Val Asn Leu Thr Ile Leu Glu Pro Asp 
        195                 200                 205             


Gln Pro Ile Trp Thr Thr Gly Leu Lys Ala Pro Leu Gly Ala Arg Val 
    210                 215                 220                 


Ser Gly Glu Glu Ile Gly Pro Gly Ala Tyr Val Tyr Leu Tyr Ile Ile 
225                 230                 235                 240 


Lys Lys Thr Arg Thr Arg Ser Thr Gln Gln Phe Arg Val Phe Glu Ser 
                245                 250                 255     


Phe Tyr Glu His Val Asn Gln Lys Leu Pro Glu Pro Pro Pro Leu Ala 
            260                 265                 270         


Ser Asn Leu Phe Ala Gln Leu Ala Glu Asn Ile Ala Ser Ser Leu His 
        275                 280                 285             


Val Ala Ser Cys Tyr Val Cys Gly Gly Met Asn Met Gly Asp Gln Trp 
    290                 295                 300                 


Pro Trp Glu Ala Arg Glu Leu Met Pro Gln Asp Asn Phe Thr Leu Thr 
305                 310                 315                 320 


Ala Ser Ser Leu Glu Pro Ala Pro Ser Ser Gln Ser Ile Trp Phe Leu 
                325                 330                 335     


Lys Thr Ser Ile Ile Gly Lys Phe Cys Ile Ala Arg Trp Gly Lys Ala 
            340                 345                 350         


Phe Thr Asp Pro Val Gly Glu Leu Thr Cys Leu Gly Gln Gln Tyr Tyr 
        355                 360                 365             


Asn Glu Thr Leu Gly Lys Thr Leu Trp Arg Gly Lys Ser Asn Asn Ser 
    370                 375                 380                 


Glu Ser Pro His Pro Ser Pro Phe Ser Arg Phe Pro Ser Leu Asn His 
385                 390                 395                 400 


Ser Trp Tyr Gln Leu Glu Ala Pro Asn Thr Trp Gln Ala Pro Ser Gly 
                405                 410                 415     


Leu Tyr Trp Ile Cys Gly Pro Gln Ala Tyr Arg Gln Leu Pro Ala Lys 
            420                 425                 430         


Trp Ser Gly Ala Cys Val Leu Gly Thr Ile Arg Pro Ser Phe Phe Leu 
        435                 440                 445             


Met Pro Leu Lys Gln Gly Glu Ala Leu Gly Tyr Pro Ile Tyr Asp Glu 
    450                 455                 460                 


Thr Lys Arg Lys Ser Lys Arg Gly Ile Thr Ile Gly Asp Trp Lys Asp 
465                 470                 475                 480 


Asn Glu Trp Pro Pro Glu Arg Ile Ile Gln Tyr Tyr Gly Pro Ala Thr 
                485                 490                 495     


Trp Ala Glu Asp Gly Met Trp Gly Tyr Arg Thr Pro Val Tyr Met Leu 
            500                 505                 510         


Asn Arg Ile Ile Arg Leu Gln Ala Val Leu Glu Ile Ile Thr Asn Glu 
        515                 520                 525             


Thr Ala Gly Ala Leu Asn Leu Leu Ala Gln Gln Ala Thr Lys Met Arg 
    530                 535                 540                 


Asn Val Ile Tyr Gln Asn Arg Leu Ala Leu Asp Tyr Leu Leu Ala Gln 
545                 550                 555                 560 


Glu Glu Gly Val Cys Gly Lys Phe Asn Leu Thr Asn Cys Cys Leu Glu 
                565                 570                 575     


Leu Asp Asp Glu Gly Lys Val Ile Lys Glu Ile Thr Ala Lys Ile Gln 
            580                 585                 590         


Lys Leu Ala His Ile Pro Val Gln Thr Trp Lys Gly 
        595                 600                 


<210>  4922
<211>  89
<212>  PRT
<213>  Homo Sapiens

<400>  4922

Met Lys Ser Val Leu Leu Leu Thr Thr Leu Leu Val Pro Ala His Leu 
1               5                   10                  15      


Val Ala Ala Trp Ser Asn Asn Tyr Ala Val Asp Cys Pro Gln His Cys 
            20                  25                  30          


Asp Ser Ser Glu Cys Lys Ser Ser Pro Arg Cys Lys Arg Thr Val Leu 
        35                  40                  45              


Asp Asp Cys Gly Cys Cys Arg Val Cys Ala Ala Gly Arg Gly Glu Thr 
    50                  55                  60                  


Cys Tyr Arg Thr Val Ser Gly Met Asp Gly Met Lys Cys Gly Pro Gly 
65                  70                  75                  80  


Leu Arg Cys Gln Pro Ser Asn Gly Glu 
                85                  


<210>  4923
<211>  184
<212>  PRT
<213>  Homo Sapiens

<400>  4923

Met Lys Ser Val Leu Leu Leu Thr Thr Leu Leu Val Pro Ala His Leu 
1               5                   10                  15      


Val Ala Ala Trp Ser Asn Asn Tyr Ala Val Asp Cys Pro Gln His Cys 
            20                  25                  30          


Asp Ser Ser Glu Cys Lys Ser Ser Pro Arg Cys Lys Arg Thr Val Leu 
        35                  40                  45              


Asp Asp Cys Gly Cys Cys Arg Val Cys Ala Ala Gly Arg Gly Glu Thr 
    50                  55                  60                  


Cys Tyr Arg Thr Val Ser Gly Met Asp Gly Met Lys Cys Gly Pro Gly 
65                  70                  75                  80  


Leu Arg Cys Gln Pro Ser Asn Gly Glu Asp Pro Phe Gly Glu Glu Phe 
                85                  90                  95      


Gly Ile Cys Lys Asp Cys Pro Tyr Gly Thr Phe Gly Met Asp Cys Arg 
            100                 105                 110         


Glu Thr Cys Asn Cys Gln Ser Gly Ile Cys Asp Arg Gly Thr Gly Lys 
        115                 120                 125             


Cys Leu Lys Phe Pro Phe Phe Gln Tyr Ser Val Thr Lys Ser Ser Asn 
    130                 135                 140                 


Arg Phe Val Ser Leu Thr Glu His Asp Met Ala Ser Gly Asp Gly Asn 
145                 150                 155                 160 


Ile Val Arg Glu Glu Val Val Lys Glu Asn Ala Ala Gly Ser Pro Val 
                165                 170                 175     


Met Arg Lys Trp Leu Asn Pro Arg 
            180                 


<210>  4924
<211>  134
<212>  PRT
<213>  Homo Sapiens

<400>  4924

Met Lys Ser Val Leu Leu Leu Thr Thr Leu Leu Val Pro Ala His Leu 
1               5                   10                  15      


Val Ala Ala Trp Ser Asn Asn Tyr Ala Val Asp Cys Pro Gln His Cys 
            20                  25                  30          


Asp Ser Ser Glu Cys Lys Ser Ser Pro Arg Cys Lys Arg Thr Val Leu 
        35                  40                  45              


Asp Asp Cys Gly Cys Cys Arg Val Cys Ala Ala Gly Arg Gly Glu Thr 
    50                  55                  60                  


Cys Tyr Arg Thr Val Ser Gly Met Asp Gly Met Lys Cys Gly Pro Gly 
65                  70                  75                  80  


Leu Arg Cys Gln Pro Ser Asn Gly Glu Asp Pro Phe Gly Glu Glu Phe 
                85                  90                  95      


Gly Ile Cys Lys Glu His Asp Met Ala Ser Gly Asp Gly Asn Ile Val 
            100                 105                 110         


Arg Glu Glu Val Val Lys Glu Asn Ala Ala Gly Ser Pro Val Met Arg 
        115                 120                 125             


Lys Trp Leu Asn Pro Arg 
    130                 


<210>  4925
<211>  522
<212>  PRT
<213>  Homo Sapiens

<400>  4925

Glu Phe Lys Lys Cys Cys Pro Gly Ser Pro Asp Ile Asp Lys Leu Asp 
1               5                   10                  15      


Val Ala Thr Met Thr Glu Tyr Leu Asn Phe Glu Lys Ser Ser Ser Val 
            20                  25                  30          


Ser Arg Tyr Gly Ala Ser Gln Val Glu Asp Met Gly Asn Ile Ile Leu 
        35                  40                  45              


Ala Met Ile Ser Glu Pro Tyr Asn His Arg Phe Ser Asp Pro Glu Arg 
    50                  55                  60                  


Val Asn Tyr Lys Phe Glu Ser Gly Thr Cys Ser Lys Met Glu Leu Ile 
65                  70                  75                  80  


Asp Asp Asn Thr Val Val Arg Ala Arg Gly Leu Pro Trp Gln Ser Ser 
                85                  90                  95      


Asp Gln Asp Ile Ala Arg Phe Phe Lys Gly Leu Asn Ile Ala Lys Gly 
            100                 105                 110         


Gly Ala Ala Leu Cys Leu Asn Ala Gln Gly Arg Arg Asn Gly Glu Ala 
        115                 120                 125             


Leu Val Arg Phe Val Ser Glu Glu His Arg Asp Leu Ala Leu Gln Arg 
    130                 135                 140                 


His Lys His His Met Gly Thr Arg Tyr Ile Glu Val Tyr Lys Ala Thr 
145                 150                 155                 160 


Gly Glu Asp Phe Leu Lys Ile Ala Gly Gly Thr Ser Asn Glu Val Ala 
                165                 170                 175     


Gln Phe Leu Ser Lys Glu Asn Gln Val Ile Val Arg Met Arg Gly Leu 
            180                 185                 190         


Pro Phe Thr Ala Thr Ala Glu Glu Val Val Ala Phe Phe Gly Gln His 
        195                 200                 205             


Cys Pro Ile Thr Gly Gly Lys Glu Gly Ile Leu Phe Val Thr Tyr Pro 
    210                 215                 220                 


Asp Gly Arg Pro Thr Gly Asp Ala Phe Val Leu Phe Ala Cys Glu Glu 
225                 230                 235                 240 


Tyr Ala Gln Asn Ala Leu Arg Lys His Lys Asp Leu Leu Gly Lys Arg 
                245                 250                 255     


Tyr Ile Glu Leu Phe Arg Ser Thr Ala Ala Glu Val Gln Gln Val Leu 
            260                 265                 270         


Asn Arg Phe Ser Ser Ala Pro Leu Ile Pro Leu Pro Thr Pro Pro Ile 
        275                 280                 285             


Ile Pro Val Leu Pro Gln Gln Phe Val Pro Pro Thr Asn Val Arg Asp 
    290                 295                 300                 


Cys Ile Arg Leu Arg Gly Leu Pro Tyr Ala Ala Thr Ile Glu Asp Ile 
305                 310                 315                 320 


Leu Asp Phe Leu Gly Glu Phe Ala Thr Asp Ile Arg Thr His Gly Val 
                325                 330                 335     


His Met Val Leu Asn His Gln Gly Arg Pro Ser Gly Asp Ala Phe Ile 
            340                 345                 350         


Gln Met Lys Ser Ala Asp Arg Ala Phe Met Ala Ala Gln Lys Cys His 
        355                 360                 365             


Lys Lys Asn Met Lys Asp Arg Tyr Val Glu Val Phe Gln Cys Ser Ala 
    370                 375                 380                 


Glu Glu Met Asn Phe Val Leu Met Gly Gly Thr Leu Asn Arg Asn Gly 
385                 390                 395                 400 


Leu Ser Pro Pro Pro Cys Lys Leu Pro Cys Leu Ser Pro Pro Ser Tyr 
                405                 410                 415     


Thr Phe Pro Ala Pro Ala Ala Val Ile Pro Thr Glu Ala Ala Ile Tyr 
            420                 425                 430         


Gln Pro Ser Val Ile Leu Asn Pro Arg Ala Leu Gln Pro Ser Thr Ala 
        435                 440                 445             


Tyr Tyr Pro Ala Gly Thr Gln Leu Phe Met Asn Tyr Thr Ala Tyr Tyr 
    450                 455                 460                 


Pro Ser Pro Pro Gly Ser Pro Asn Ser Leu Gly Tyr Phe Pro Thr Ala 
465                 470                 475                 480 


Ala Asn Leu Ser Gly Val Pro Pro Gln Pro Gly Thr Val Val Arg Met 
                485                 490                 495     


Gln Gly Leu Ala Tyr Asn Thr Gly Val Lys Glu Ile Leu Asn Phe Phe 
            500                 505                 510         


Gln Gly Tyr Gln Cys Leu Lys Asp Val Trp 
        515                 520         


<210>  4926
<211>  677
<212>  PRT
<213>  Homo Sapiens

<400>  4926

Met Thr Ala Ser Pro Asp Tyr Leu Val Val Leu Phe Gly Ile Thr Ala 
1               5                   10                  15      


Gly Ala Thr Gly Ala Lys Leu Gly Ser Asp Glu Lys Glu Leu Ile Leu 
            20                  25                  30          


Leu Phe Trp Lys Val Val Asp Leu Ala Asn Lys Lys Val Gly Gln Leu 
        35                  40                  45              


His Glu Val Leu Val Arg Pro Asp Gln Leu Glu Leu Thr Glu Asp Cys 
    50                  55                  60                  


Lys Glu Glu Thr Lys Ile Asp Val Glu Ser Leu Ser Ser Ala Ser Gln 
65                  70                  75                  80  


Leu Asp Gln Ala Leu Arg Gln Phe Asn Gln Ser Val Ser Asn Glu Leu 
                85                  90                  95      


Asn Ile Gly Val Gly Thr Ser Phe Cys Leu Cys Thr Asp Gly Gln Leu 
            100                 105                 110         


His Val Arg Gln Ile Leu His Pro Glu Ala Ser Lys Lys Asn Val Leu 
        115                 120                 125             


Leu Pro Glu Cys Phe Tyr Ser Phe Phe Asp Leu Arg Lys Glu Phe Lys 
    130                 135                 140                 


Lys Cys Cys Pro Gly Ser Pro Asp Ile Asp Lys Leu Asp Val Ala Thr 
145                 150                 155                 160 


Met Thr Glu Tyr Leu Asn Phe Glu Lys Ser Ser Ser Val Ser Arg Tyr 
                165                 170                 175     


Gly Ala Ser Gln Val Glu Asp Met Gly Asn Ile Ile Leu Ala Met Ile 
            180                 185                 190         


Ser Glu Pro Tyr Asn His Arg Phe Ser Asp Pro Glu Arg Val Asn Tyr 
        195                 200                 205             


Lys Phe Glu Ser Gly Thr Cys Ser Lys Met Glu Leu Ile Asp Asp Asn 
    210                 215                 220                 


Thr Val Val Arg Ala Arg Gly Leu Pro Trp Gln Ser Ser Asp Gln Asp 
225                 230                 235                 240 


Ile Ala Arg Phe Phe Lys Gly Leu Asn Ile Ala Lys Gly Gly Ala Ala 
                245                 250                 255     


Leu Cys Leu Asn Ala Gln Gly Arg Arg Asn Gly Glu Ala Leu Val Arg 
            260                 265                 270         


Phe Val Ser Glu Glu His Arg Asp Leu Ala Leu Gln Arg His Lys His 
        275                 280                 285             


His Met Gly Thr Arg Tyr Ile Glu Val Tyr Lys Ala Thr Gly Glu Asp 
    290                 295                 300                 


Phe Leu Lys Ile Ala Gly Gly Thr Ser Asn Glu Val Ala Gln Phe Leu 
305                 310                 315                 320 


Ser Lys Glu Asn Gln Val Ile Val Arg Met Arg Gly Leu Pro Phe Thr 
                325                 330                 335     


Ala Thr Ala Glu Glu Val Val Ala Phe Phe Gly Gln His Cys Pro Ile 
            340                 345                 350         


Thr Gly Gly Lys Glu Gly Ile Leu Phe Val Thr Tyr Pro Asp Gly Arg 
        355                 360                 365             


Pro Thr Gly Asp Ala Phe Val Leu Phe Ala Cys Glu Glu Tyr Ala Gln 
    370                 375                 380                 


Asn Ala Leu Arg Lys His Lys Asp Leu Leu Gly Lys Arg Tyr Ile Glu 
385                 390                 395                 400 


Leu Phe Arg Ser Thr Ala Ala Glu Val Gln Gln Val Leu Asn Arg Phe 
                405                 410                 415     


Ser Ser Ala Pro Leu Ile Pro Leu Pro Thr Pro Pro Ile Ile Pro Val 
            420                 425                 430         


Leu Pro Gln Gln Phe Val Pro Pro Thr Asn Val Arg Asp Cys Ile Arg 
        435                 440                 445             


Leu Arg Gly Leu Pro Tyr Ala Ala Thr Ile Glu Asp Ile Leu Asp Phe 
    450                 455                 460                 


Leu Gly Glu Phe Ala Thr Asp Ile Arg Thr His Gly Val His Met Val 
465                 470                 475                 480 


Leu Asn His Gln Gly Arg Pro Ser Gly Asp Ala Phe Ile Gln Met Lys 
                485                 490                 495     


Ser Ala Asp Arg Ala Phe Met Ala Ala Gln Lys Cys His Lys Lys Asn 
            500                 505                 510         


Met Lys Asp Arg Tyr Val Glu Val Phe Gln Cys Ser Ala Glu Glu Met 
        515                 520                 525             


Asn Phe Val Leu Met Gly Gly Thr Leu Asn Arg Asn Gly Leu Ser Pro 
    530                 535                 540                 


Pro Pro Cys Leu Ser Pro Pro Ser Tyr Thr Phe Pro Ala Pro Ala Ala 
545                 550                 555                 560 


Val Ile Pro Thr Glu Ala Ala Ile Tyr Gln Pro Ser Val Ile Leu Asn 
                565                 570                 575     


Pro Arg Ala Leu Gln Pro Ser Thr Ala Tyr Tyr Pro Ala Gly Thr Gln 
            580                 585                 590         


Leu Phe Met Asn Tyr Thr Ala Tyr Tyr Pro Ser Pro Pro Gly Ser Pro 
        595                 600                 605             


Asn Ser Leu Gly Tyr Phe Pro Thr Ala Ala Asn Leu Ser Gly Val Pro 
    610                 615                 620                 


Pro Gln Pro Gly Thr Val Val Arg Met Gln Gly Leu Ala Tyr Asn Thr 
625                 630                 635                 640 


Gly Val Lys Glu Ile Leu Asn Phe Phe Gln Gly Tyr Gln Tyr Ala Thr 
                645                 650                 655     


Glu Asp Gly Leu Ile His Thr Asn Asp Gln Ala Arg Thr Leu Pro Lys 
            660                 665                 670         


Glu Trp Val Cys Ile 
        675         


<210>  4927
<211>  681
<212>  PRT
<213>  Homo Sapiens

<400>  4927

Met Thr Ala Ser Pro Asp Tyr Leu Val Val Leu Phe Gly Ile Thr Ala 
1               5                   10                  15      


Gly Ala Thr Gly Ala Lys Leu Gly Ser Asp Glu Lys Glu Leu Ile Leu 
            20                  25                  30          


Leu Phe Trp Lys Val Val Asp Leu Ala Asn Lys Lys Val Gly Gln Leu 
        35                  40                  45              


His Glu Val Leu Val Arg Pro Asp Gln Leu Glu Leu Thr Glu Asp Cys 
    50                  55                  60                  


Lys Glu Glu Thr Lys Ile Asp Val Glu Ser Leu Ser Ser Ala Ser Gln 
65                  70                  75                  80  


Leu Asp Gln Ala Leu Arg Gln Phe Asn Gln Ser Val Ser Asn Glu Leu 
                85                  90                  95      


Asn Ile Gly Val Gly Thr Ser Phe Cys Leu Cys Thr Asp Gly Gln Leu 
            100                 105                 110         


His Val Arg Gln Ile Leu His Pro Glu Ala Ser Lys Lys Asn Val Leu 
        115                 120                 125             


Leu Pro Glu Cys Phe Tyr Ser Phe Phe Asp Leu Arg Lys Glu Phe Lys 
    130                 135                 140                 


Lys Cys Cys Pro Gly Ser Pro Asp Ile Asp Lys Leu Asp Val Ala Thr 
145                 150                 155                 160 


Met Thr Glu Tyr Leu Asn Phe Glu Lys Ser Ser Ser Val Ser Arg Tyr 
                165                 170                 175     


Gly Ala Ser Gln Val Glu Asp Met Gly Asn Ile Ile Leu Ala Met Ile 
            180                 185                 190         


Ser Glu Pro Tyr Asn His Arg Phe Ser Asp Pro Glu Arg Val Asn Tyr 
        195                 200                 205             


Lys Phe Glu Ser Gly Thr Cys Ser Lys Met Glu Leu Ile Asp Asp Asn 
    210                 215                 220                 


Thr Val Val Arg Ala Arg Gly Leu Pro Trp Gln Ser Ser Asp Gln Asp 
225                 230                 235                 240 


Ile Ala Arg Phe Phe Lys Gly Leu Asn Ile Ala Lys Gly Gly Ala Ala 
                245                 250                 255     


Leu Cys Leu Asn Ala Gln Gly Arg Arg Asn Gly Glu Ala Leu Val Arg 
            260                 265                 270         


Phe Val Ser Glu Glu His Arg Asp Leu Ala Leu Gln Arg His Lys His 
        275                 280                 285             


His Met Gly Thr Arg Tyr Ile Glu Val Tyr Lys Ala Thr Gly Glu Asp 
    290                 295                 300                 


Phe Leu Lys Ile Ala Gly Gly Thr Ser Asn Glu Val Ala Gln Phe Leu 
305                 310                 315                 320 


Ser Lys Glu Asn Gln Val Ile Val Arg Met Arg Gly Leu Pro Phe Thr 
                325                 330                 335     


Ala Thr Ala Glu Glu Val Val Ala Phe Phe Gly Gln His Cys Pro Ile 
            340                 345                 350         


Thr Gly Gly Lys Glu Gly Ile Leu Phe Val Thr Tyr Pro Asp Gly Arg 
        355                 360                 365             


Pro Thr Gly Asp Ala Phe Val Leu Phe Ala Cys Glu Glu Tyr Ala Gln 
    370                 375                 380                 


Asn Ala Leu Arg Lys His Lys Asp Leu Leu Gly Lys Arg Tyr Ile Glu 
385                 390                 395                 400 


Leu Phe Arg Ser Thr Ala Ala Glu Val Gln Gln Val Leu Asn Arg Phe 
                405                 410                 415     


Ser Ser Ala Pro Leu Ile Pro Leu Pro Thr Pro Pro Ile Ile Pro Val 
            420                 425                 430         


Leu Pro Gln Gln Phe Val Pro Pro Thr Asn Val Arg Asp Cys Ile Arg 
        435                 440                 445             


Leu Arg Gly Leu Pro Tyr Ala Ala Thr Ile Glu Asp Ile Leu Asp Phe 
    450                 455                 460                 


Leu Gly Glu Phe Ala Thr Asp Ile Arg Thr His Gly Val His Met Val 
465                 470                 475                 480 


Leu Asn His Gln Gly Arg Pro Ser Gly Asp Ala Phe Ile Gln Met Lys 
                485                 490                 495     


Ser Ala Asp Arg Ala Phe Met Ala Ala Gln Lys Cys His Lys Lys Asn 
            500                 505                 510         


Met Lys Asp Arg Tyr Val Glu Val Phe Gln Cys Ser Ala Glu Glu Met 
        515                 520                 525             


Asn Phe Val Leu Met Gly Gly Thr Leu Asn Arg Asn Gly Leu Ser Pro 
    530                 535                 540                 


Pro Pro Cys Lys Leu Pro Cys Leu Ser Pro Pro Ser Tyr Thr Phe Pro 
545                 550                 555                 560 


Ala Pro Ala Ala Val Ile Pro Thr Glu Ala Ala Ile Tyr Gln Pro Ser 
                565                 570                 575     


Val Ile Leu Asn Pro Arg Ala Leu Gln Pro Ser Thr Ala Tyr Tyr Pro 
            580                 585                 590         


Ala Gly Thr Gln Leu Phe Met Asn Tyr Thr Ala Tyr Tyr Pro Ser Pro 
        595                 600                 605             


Pro Gly Ser Pro Asn Ser Leu Gly Tyr Phe Pro Thr Ala Ala Asn Leu 
    610                 615                 620                 


Ser Gly Val Pro Pro Gln Pro Gly Thr Val Val Arg Met Gln Gly Leu 
625                 630                 635                 640 


Ala Tyr Asn Thr Gly Val Lys Glu Ile Leu Asn Phe Phe Gln Gly Tyr 
                645                 650                 655     


Gln Tyr Ala Thr Glu Asp Gly Leu Ile His Thr Asn Asp Gln Ala Arg 
            660                 665                 670         


Thr Leu Pro Lys Glu Trp Val Cys Ile 
        675                 680     


<210>  4928
<211>  659
<212>  PRT
<213>  Homo Sapiens

<400>  4928

Met Thr Ala Ser Pro Asp Tyr Leu Val Val Leu Phe Gly Ile Thr Ala 
1               5                   10                  15      


Gly Ala Thr Gly Ala Lys Leu Gly Ser Asp Glu Lys Glu Leu Ile Leu 
            20                  25                  30          


Leu Phe Trp Lys Val Val Asp Leu Ala Asn Lys Lys Val Gly Gln Leu 
        35                  40                  45              


His Glu Val Leu Val Arg Pro Asp Gln Leu Glu Leu Thr Glu Asp Cys 
    50                  55                  60                  


Lys Glu Glu Thr Lys Ile Asp Val Glu Ser Leu Ser Ser Ala Ser Gln 
65                  70                  75                  80  


Leu Asp Gln Ala Leu Arg Gln Phe Asn Gln Ser Val Ser Asn Glu Leu 
                85                  90                  95      


Asn Ile Gly Val Gly Thr Ser Phe Cys Leu Cys Thr Asp Gly Gln Leu 
            100                 105                 110         


His Val Arg Gln Ile Leu His Pro Glu Ala Ser Lys Lys Asn Val Leu 
        115                 120                 125             


Leu Pro Glu Cys Phe Tyr Ser Phe Phe Asp Leu Arg Lys Glu Phe Lys 
    130                 135                 140                 


Lys Cys Cys Pro Gly Ser Pro Asp Ile Asp Lys Leu Asp Val Ala Thr 
145                 150                 155                 160 


Met Thr Glu Tyr Leu Asn Phe Glu Lys Ser Ser Ser Val Ser Arg Tyr 
                165                 170                 175     


Gly Ala Ser Gln Val Glu Asp Met Gly Asn Ile Ile Leu Ala Met Ile 
            180                 185                 190         


Ser Glu Pro Tyr Asn His Arg Phe Ser Asp Pro Glu Arg Val Asn Tyr 
        195                 200                 205             


Lys Phe Glu Ser Gly Thr Cys Ser Lys Met Glu Leu Ile Asp Asp Asn 
    210                 215                 220                 


Thr Val Val Arg Ala Arg Gly Leu Pro Trp Gln Ser Ser Asp Gln Asp 
225                 230                 235                 240 


Ile Ala Arg Phe Phe Lys Gly Leu Asn Ile Ala Lys Gly Gly Ala Ala 
                245                 250                 255     


Leu Cys Leu Asn Ala Gln Gly Arg Arg Asn Gly Glu Ala Leu Val Arg 
            260                 265                 270         


Phe Val Ser Glu Glu His Arg Asp Leu Ala Leu Gln Arg His Lys His 
        275                 280                 285             


His Met Gly Thr Arg Tyr Ile Glu Val Tyr Lys Ala Thr Gly Glu Asp 
    290                 295                 300                 


Phe Leu Lys Ile Ala Gly Gly Thr Ser Asn Glu Val Ala Gln Phe Leu 
305                 310                 315                 320 


Ser Lys Glu Asn Gln Val Ile Val Arg Met Arg Gly Leu Pro Phe Thr 
                325                 330                 335     


Ala Thr Ala Glu Glu Val Val Ala Phe Phe Gly Gln His Cys Pro Ile 
            340                 345                 350         


Thr Gly Gly Lys Glu Gly Ile Leu Phe Val Thr Tyr Pro Asp Gly Arg 
        355                 360                 365             


Pro Thr Gly Asp Ala Phe Val Leu Phe Ala Cys Glu Glu Tyr Ala Gln 
    370                 375                 380                 


Asn Ala Leu Arg Lys His Lys Asp Leu Leu Gly Lys Arg Tyr Ile Glu 
385                 390                 395                 400 


Leu Phe Arg Ser Thr Ala Ala Glu Val Gln Gln Val Leu Asn Arg Phe 
                405                 410                 415     


Ser Ser Ala Pro Leu Ile Pro Leu Pro Thr Pro Pro Ile Ile Pro Val 
            420                 425                 430         


Leu Pro Gln Gln Phe Val Pro Pro Thr Asn Val Arg Asp Cys Ile Arg 
        435                 440                 445             


Leu Arg Gly Leu Pro Tyr Ala Ala Thr Ile Glu Asp Ile Leu Asp Phe 
    450                 455                 460                 


Leu Gly Glu Phe Ala Thr Asp Ile Arg Thr His Gly Val His Met Val 
465                 470                 475                 480 


Leu Asn His Gln Gly Arg Pro Ser Gly Asp Ala Phe Ile Gln Met Lys 
                485                 490                 495     


Ser Ala Asp Arg Ala Phe Met Ala Ala Gln Lys Cys His Lys Lys Asn 
            500                 505                 510         


Met Lys Asp Arg Tyr Val Glu Val Phe Gln Cys Ser Ala Glu Glu Met 
        515                 520                 525             


Asn Phe Val Leu Met Gly Gly Thr Leu Asn Arg Asn Gly Leu Ser Pro 
    530                 535                 540                 


Pro Pro Cys Leu Ser Pro Pro Ser Tyr Thr Phe Pro Ala Pro Ala Ala 
545                 550                 555                 560 


Val Ile Pro Thr Glu Ala Ala Ile Tyr Gln Pro Ser Val Ile Leu Asn 
                565                 570                 575     


Pro Arg Ala Leu Gln Pro Ser Thr Ala Tyr Tyr Pro Ala Gly Thr Gln 
            580                 585                 590         


Leu Phe Met Asn Tyr Thr Ala Tyr Tyr Pro Ser Pro Pro Gly Ser Pro 
        595                 600                 605             


Asn Ser Leu Gly Tyr Phe Pro Thr Ala Ala Asn Leu Ser Gly Val Pro 
    610                 615                 620                 


Pro Gln Pro Gly Thr Val Val Arg Met Gln Gly Leu Ala Tyr Asn Thr 
625                 630                 635                 640 


Gly Val Lys Glu Ile Leu Asn Phe Phe Gln Gly Tyr Gln Cys Leu Lys 
                645                 650                 655     


Asp Val Trp 
            


<210>  4929
<211>  604
<212>  PRT
<213>  Homo Sapiens

<400>  4929

Met Thr Ala Ser Pro Asp Tyr Leu Val Val Leu Phe Gly Ile Thr Ala 
1               5                   10                  15      


Gly Ala Thr Gly Ala Lys Leu Gly Ser Asp Glu Lys Glu Leu Ile Leu 
            20                  25                  30          


Leu Phe Trp Lys Val Val Asp Leu Ala Asn Lys Lys Val Gly Gln Leu 
        35                  40                  45              


His Glu Val Leu Val Arg Pro Asp Gln Leu Glu Leu Thr Glu Asp Cys 
    50                  55                  60                  


Lys Glu Glu Thr Lys Ile Asp Val Glu Ser Leu Ser Ser Ala Ser Gln 
65                  70                  75                  80  


Leu Asp Gln Ala Leu Arg Gln Phe Asn Gln Ser Val Ser Asn Glu Leu 
                85                  90                  95      


Asn Ile Gly Val Gly Thr Ser Phe Cys Leu Cys Thr Asp Gly Gln Leu 
            100                 105                 110         


His Val Arg Gln Ile Leu His Pro Glu Ala Ser Lys Lys Asn Val Leu 
        115                 120                 125             


Leu Pro Glu Cys Phe Tyr Ser Phe Phe Asp Leu Arg Lys Glu Phe Lys 
    130                 135                 140                 


Lys Cys Cys Pro Gly Ser Pro Asp Ile Asp Lys Leu Asp Val Ala Thr 
145                 150                 155                 160 


Met Thr Glu Tyr Leu Asn Phe Glu Lys Ser Ser Ser Val Ser Arg Tyr 
                165                 170                 175     


Gly Ala Ser Gln Val Glu Asp Met Gly Asn Ile Ile Leu Ala Met Ile 
            180                 185                 190         


Ser Glu Pro Tyr Asn His Arg Phe Ser Asp Pro Glu Arg Val Asn Tyr 
        195                 200                 205             


Lys Phe Glu Ser Gly Thr Cys Ser Lys Met Glu Leu Ile Asp Asp Asn 
    210                 215                 220                 


Thr Val Val Arg Ala Arg Gly Leu Pro Trp Gln Ser Ser Asp Gln Asp 
225                 230                 235                 240 


Ile Ala Arg Phe Phe Lys Gly Leu Asn Ile Ala Lys Gly Gly Ala Ala 
                245                 250                 255     


Leu Cys Leu Asn Ala Gln Gly Arg Arg Asn Gly Glu Ala Leu Val Arg 
            260                 265                 270         


Phe Val Ser Glu Glu His Arg Asp Leu Ala Leu Gln Arg His Lys His 
        275                 280                 285             


His Met Gly Thr Arg Tyr Ile Glu Val Tyr Lys Ala Thr Gly Glu Asp 
    290                 295                 300                 


Phe Leu Lys Ile Ala Gly Gly Thr Ser Asn Glu Val Ala Gln Phe Leu 
305                 310                 315                 320 


Ser Lys Glu Asn Gln Val Ile Val Arg Met Arg Gly Leu Pro Phe Thr 
                325                 330                 335     


Ala Thr Ala Glu Glu Val Val Ala Phe Phe Gly Gln His Cys Pro Ile 
            340                 345                 350         


Thr Gly Gly Lys Glu Gly Ile Leu Phe Val Thr Tyr Pro Asp Gly Arg 
        355                 360                 365             


Pro Thr Gly Asp Ala Phe Val Leu Phe Ala Cys Glu Glu Tyr Ala Gln 
    370                 375                 380                 


Asn Ala Leu Arg Lys His Lys Asp Leu Leu Gly Lys Arg Tyr Ile Glu 
385                 390                 395                 400 


Leu Phe Arg Ser Thr Ala Ala Glu Val Gln Gln Val Leu Asn Arg Phe 
                405                 410                 415     


Ser Ser Ala Pro Leu Ile Pro Leu Pro Thr Pro Pro Ile Ile Pro Val 
            420                 425                 430         


Leu Pro Gln Gln Phe Val Pro Pro Thr Asn Val Arg Asp Cys Ile Arg 
        435                 440                 445             


Leu Arg Gly Leu Pro Tyr Ala Ala Thr Ile Glu Asp Ile Leu Asp Phe 
    450                 455                 460                 


Leu Gly Glu Phe Ala Thr Asp Ile Arg Thr His Gly Val His Met Val 
465                 470                 475                 480 


Leu Asn His Gln Gly Arg Pro Ser Gly Asp Ala Phe Ile Gln Met Lys 
                485                 490                 495     


Ser Ala Asp Arg Ala Phe Met Ala Ala Gln Lys Cys His Lys Lys Asn 
            500                 505                 510         


Met Lys Asp Arg Tyr Val Glu Val Phe Gln Cys Ser Ala Glu Glu Met 
        515                 520                 525             


Asn Phe Val Leu Met Gly Gly Thr Leu Asn Arg Asn Gly Leu Ser Pro 
    530                 535                 540                 


Pro Pro Cys Leu Ser Pro Pro Ser Tyr Thr Phe Pro Ala Pro Ala Ala 
545                 550                 555                 560 


Val Ile Pro Thr Glu Ala Ala Ile Tyr Gln Pro Ser Val Ile Leu Asn 
                565                 570                 575     


Pro Arg Ala Leu Gln Pro Ser Thr Ala Tyr Tyr Pro Ala Gly Thr Gln 
            580                 585                 590         


Leu Phe Met Asn Tyr Thr Ala Tyr Tyr Pro Ser Val 
        595                 600                 


<210>  4930
<211>  681
<212>  PRT
<213>  Homo Sapiens

<400>  4930

Met Thr Ala Ser Pro Asp Tyr Leu Val Val Leu Phe Gly Ile Thr Ala 
1               5                   10                  15      


Gly Ala Thr Gly Ala Lys Leu Gly Ser Asp Glu Lys Glu Leu Ile Leu 
            20                  25                  30          


Leu Phe Trp Lys Val Val Asp Leu Ala Asn Lys Lys Val Gly Gln Leu 
        35                  40                  45              


His Glu Val Leu Val Arg Pro Asp Gln Leu Glu Leu Thr Glu Asp Cys 
    50                  55                  60                  


Lys Glu Glu Thr Lys Ile Asp Val Glu Ser Leu Ser Ser Ala Ser Gln 
65                  70                  75                  80  


Leu Asp Gln Ala Leu Arg Gln Phe Asn Gln Ser Val Ser Asn Glu Leu 
                85                  90                  95      


Asn Ile Gly Val Gly Thr Ser Phe Cys Leu Cys Thr Asp Gly Gln Leu 
            100                 105                 110         


His Val Arg Gln Ile Leu His Pro Glu Ala Ser Lys Lys Asn Val Leu 
        115                 120                 125             


Leu Pro Glu Cys Phe Tyr Ser Phe Phe Asp Leu Arg Lys Glu Phe Lys 
    130                 135                 140                 


Lys Cys Cys Pro Gly Ser Pro Asp Ile Asp Lys Leu Asp Val Ala Thr 
145                 150                 155                 160 


Met Thr Glu Tyr Leu Asn Phe Glu Lys Ser Ser Ser Val Ser Arg Tyr 
                165                 170                 175     


Gly Ala Ser Gln Val Glu Asp Met Gly Asn Ile Ile Leu Ala Met Ile 
            180                 185                 190         


Ser Glu Pro Tyr Asn His Arg Phe Ser Asp Pro Glu Arg Val Asn Tyr 
        195                 200                 205             


Lys Phe Glu Ser Gly Thr Cys Ser Lys Met Glu Leu Ile Asp Asp Asn 
    210                 215                 220                 


Thr Val Val Arg Ala Arg Gly Leu Pro Trp Gln Ser Ser Asp Gln Asp 
225                 230                 235                 240 


Ile Ala Arg Phe Phe Lys Gly Leu Asn Ile Ala Lys Gly Gly Ala Ala 
                245                 250                 255     


Leu Cys Leu Asn Ala Gln Gly Arg Arg Asn Gly Glu Ala Leu Val Arg 
            260                 265                 270         


Phe Val Ser Glu Glu His Arg Asp Leu Ala Leu Gln Arg His Lys His 
        275                 280                 285             


His Met Gly Thr Arg Tyr Ile Glu Val Tyr Lys Ala Thr Gly Glu Asp 
    290                 295                 300                 


Phe Leu Lys Ile Ala Gly Gly Thr Ser Asn Glu Val Ala Gln Phe Leu 
305                 310                 315                 320 


Ser Lys Glu Asn Gln Val Ile Val Arg Met Arg Gly Leu Pro Phe Thr 
                325                 330                 335     


Ala Thr Ala Glu Glu Val Val Ala Phe Phe Gly Gln His Cys Pro Ile 
            340                 345                 350         


Thr Gly Gly Lys Glu Gly Ile Leu Phe Val Thr Tyr Pro Asp Gly Arg 
        355                 360                 365             


Pro Thr Gly Asp Ala Phe Val Leu Phe Ala Cys Glu Glu Tyr Ala Gln 
    370                 375                 380                 


Asn Ala Leu Arg Lys His Lys Asp Leu Leu Gly Lys Arg Tyr Ile Glu 
385                 390                 395                 400 


Leu Phe Arg Ser Thr Ala Ala Glu Val Gln Gln Val Leu Asn Arg Phe 
                405                 410                 415     


Ser Ser Ala Pro Leu Ile Pro Leu Pro Thr Pro Pro Ile Ile Pro Val 
            420                 425                 430         


Leu Pro Gln Gln Phe Val Pro Pro Thr Asn Val Arg Asp Cys Ile Arg 
        435                 440                 445             


Leu Arg Gly Leu Pro Tyr Ala Ala Thr Ile Glu Asp Ile Leu Asp Phe 
    450                 455                 460                 


Leu Gly Glu Phe Ala Thr Asp Ile Arg Thr His Gly Val His Met Val 
465                 470                 475                 480 


Leu Asn His Gln Gly Arg Pro Ser Gly Asp Ala Phe Ile Gln Met Lys 
                485                 490                 495     


Ser Ala Asp Arg Ala Phe Met Ala Ala Gln Lys Cys His Lys Lys Asn 
            500                 505                 510         


Met Lys Asp Arg Tyr Val Glu Val Phe Gln Cys Ser Ala Glu Glu Met 
        515                 520                 525             


Asn Phe Val Leu Met Gly Gly Thr Leu Asn Arg Asn Gly Leu Ser Pro 
    530                 535                 540                 


Pro Pro Cys Lys Leu Pro Cys Leu Ser Pro Pro Ser Tyr Thr Phe Pro 
545                 550                 555                 560 


Ala Pro Ala Ala Val Ile Pro Thr Glu Ala Ala Ile Tyr Gln Pro Ser 
                565                 570                 575     


Val Ile Leu Asn Pro Arg Ala Leu Gln Pro Ser Thr Ala Tyr Tyr Pro 
            580                 585                 590         


Ala Gly Thr Gln Leu Phe Met Asn Tyr Thr Ala Tyr Tyr Pro Ser Pro 
        595                 600                 605             


Pro Gly Ser Pro Asn Ser Leu Gly Tyr Phe Pro Thr Ala Ala Asn Leu 
    610                 615                 620                 


Ser Gly Val Pro Pro Gln Pro Gly Thr Val Val Arg Met Gln Gly Leu 
625                 630                 635                 640 


Ala Tyr Asn Thr Gly Val Lys Glu Ile Leu Asn Phe Phe Gln Gly Tyr 
                645                 650                 655     


Gln Tyr Ala Thr Glu Asp Gly Leu Ile His Thr Asn Asp Gln Ala Arg 
            660                 665                 670         


Thr Leu Pro Lys Glu Trp Val Cys Ile 
        675                 680     


<210>  4931
<211>  608
<212>  PRT
<213>  Homo Sapiens

<400>  4931

Met Thr Ala Ser Pro Asp Tyr Leu Val Val Leu Phe Gly Ile Thr Ala 
1               5                   10                  15      


Gly Ala Thr Gly Ala Lys Leu Gly Ser Asp Glu Lys Glu Leu Ile Leu 
            20                  25                  30          


Leu Phe Trp Lys Val Val Asp Leu Ala Asn Lys Lys Val Gly Gln Leu 
        35                  40                  45              


His Glu Val Leu Val Arg Pro Asp Gln Leu Glu Leu Thr Glu Asp Cys 
    50                  55                  60                  


Lys Glu Glu Thr Lys Ile Asp Val Glu Ser Leu Ser Ser Ala Ser Gln 
65                  70                  75                  80  


Leu Asp Gln Ala Leu Arg Gln Phe Asn Gln Ser Val Ser Asn Glu Leu 
                85                  90                  95      


Asn Ile Gly Val Gly Thr Ser Phe Cys Leu Cys Thr Asp Gly Gln Leu 
            100                 105                 110         


His Val Arg Gln Ile Leu His Pro Glu Ala Ser Lys Lys Asn Val Leu 
        115                 120                 125             


Leu Pro Glu Cys Phe Tyr Ser Phe Phe Asp Leu Arg Lys Glu Phe Lys 
    130                 135                 140                 


Lys Cys Cys Pro Gly Ser Pro Asp Ile Asp Lys Leu Asp Val Ala Thr 
145                 150                 155                 160 


Met Thr Glu Tyr Leu Asn Phe Glu Lys Ser Ser Ser Val Ser Arg Tyr 
                165                 170                 175     


Gly Ala Ser Gln Val Glu Asp Met Gly Asn Ile Ile Leu Ala Met Ile 
            180                 185                 190         


Ser Glu Pro Tyr Asn His Arg Phe Ser Asp Pro Glu Arg Val Asn Tyr 
        195                 200                 205             


Lys Phe Glu Ser Gly Thr Cys Ser Lys Met Glu Leu Ile Asp Asp Asn 
    210                 215                 220                 


Thr Val Val Arg Ala Arg Gly Leu Pro Trp Gln Ser Ser Asp Gln Asp 
225                 230                 235                 240 


Ile Ala Arg Phe Phe Lys Gly Leu Asn Ile Ala Lys Gly Gly Ala Ala 
                245                 250                 255     


Leu Cys Leu Asn Ala Gln Gly Arg Arg Asn Gly Glu Ala Leu Val Arg 
            260                 265                 270         


Phe Val Ser Glu Glu His Arg Asp Leu Ala Leu Gln Arg His Lys His 
        275                 280                 285             


His Met Gly Thr Arg Tyr Ile Glu Val Tyr Lys Ala Thr Gly Glu Asp 
    290                 295                 300                 


Phe Leu Lys Ile Ala Gly Gly Thr Ser Asn Glu Val Ala Gln Phe Leu 
305                 310                 315                 320 


Ser Lys Glu Asn Gln Val Ile Val Arg Met Arg Gly Leu Pro Phe Thr 
                325                 330                 335     


Ala Thr Ala Glu Glu Val Val Ala Phe Phe Gly Gln His Cys Pro Ile 
            340                 345                 350         


Thr Gly Gly Lys Glu Gly Ile Leu Phe Val Thr Tyr Pro Asp Gly Arg 
        355                 360                 365             


Pro Thr Gly Asp Ala Phe Val Leu Phe Ala Cys Glu Glu Tyr Ala Gln 
    370                 375                 380                 


Asn Ala Leu Arg Lys His Lys Asp Leu Leu Gly Lys Arg Tyr Ile Glu 
385                 390                 395                 400 


Leu Phe Arg Ser Thr Ala Ala Glu Val Gln Gln Val Leu Asn Arg Phe 
                405                 410                 415     


Ser Ser Ala Pro Leu Ile Pro Leu Pro Thr Pro Pro Ile Ile Pro Val 
            420                 425                 430         


Leu Pro Gln Gln Phe Val Pro Pro Thr Asn Val Arg Asp Cys Ile Arg 
        435                 440                 445             


Leu Arg Gly Leu Pro Tyr Ala Ala Thr Ile Glu Asp Ile Leu Asp Phe 
    450                 455                 460                 


Leu Gly Glu Phe Ala Thr Asp Ile Arg Thr His Gly Val His Met Val 
465                 470                 475                 480 


Leu Asn His Gln Gly Arg Pro Ser Gly Asp Ala Phe Ile Gln Met Lys 
                485                 490                 495     


Ser Ala Asp Arg Ala Phe Met Ala Ala Gln Lys Cys His Lys Lys Asn 
            500                 505                 510         


Met Lys Asp Arg Tyr Val Glu Val Phe Gln Cys Ser Ala Glu Glu Met 
        515                 520                 525             


Asn Phe Val Leu Met Gly Gly Thr Leu Asn Arg Asn Gly Leu Ser Pro 
    530                 535                 540                 


Pro Pro Cys Lys Leu Pro Cys Leu Ser Pro Pro Ser Tyr Thr Phe Pro 
545                 550                 555                 560 


Ala Pro Ala Ala Val Ile Pro Thr Glu Ala Ala Ile Tyr Gln Pro Ser 
                565                 570                 575     


Val Ile Leu Asn Pro Arg Ala Leu Gln Pro Ser Thr Ala Tyr Tyr Pro 
            580                 585                 590         


Ala Gly Thr Gln Leu Phe Met Asn Tyr Thr Ala Tyr Tyr Pro Ser Val 
        595                 600                 605             


<210>  4932
<211>  502
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4932

Xaa Phe Phe Asp Leu Arg Lys Glu Phe Lys Lys Cys Cys Pro Gly Ser 
1               5                   10                  15      


Pro Asp Ile Asp Lys Leu Asp Val Ala Thr Met Thr Glu Tyr Leu Asn 
            20                  25                  30          


Phe Glu Lys Ser Ser Ser Val Ser Arg Tyr Gly Ala Ser Gln Val Glu 
        35                  40                  45              


Asp Met Gly Asn Ile Ile Leu Ala Met Ile Ser Glu Pro Tyr Asn His 
    50                  55                  60                  


Arg Phe Ser Asp Pro Glu Arg Val Asn Tyr Lys Phe Glu Ser Gly Thr 
65                  70                  75                  80  


Cys Ser Lys Met Glu Leu Ile Asp Asp Asn Thr Val Val Arg Ala Arg 
                85                  90                  95      


Gly Leu Pro Trp Gln Ser Ser Asp Gln Asp Ile Ala Arg Phe Phe Lys 
            100                 105                 110         


Gly Leu Asn Ile Ala Lys Gly Gly Ala Ala Leu Cys Leu Asn Ala Gln 
        115                 120                 125             


Gly Arg Arg Asn Gly Glu Ala Leu Val Arg Phe Val Ser Glu Glu His 
    130                 135                 140                 


Arg Asp Leu Ala Leu Gln Arg His Lys His His Met Gly Thr Arg Tyr 
145                 150                 155                 160 


Ile Glu Val Tyr Lys Ala Thr Gly Glu Asp Phe Leu Lys Ile Ala Gly 
                165                 170                 175     


Gly Thr Ser Asn Glu Val Ala Gln Phe Leu Ser Lys Glu Asn Gln Val 
            180                 185                 190         


Ile Val Arg Met Arg Gly Leu Pro Phe Thr Ala Thr Ala Glu Glu Val 
        195                 200                 205             


Val Ala Phe Phe Gly Gln His Cys Pro Ile Thr Gly Gly Lys Glu Gly 
    210                 215                 220                 


Ile Leu Phe Val Thr Tyr Pro Asp Gly Arg Pro Thr Gly Asp Ala Phe 
225                 230                 235                 240 


Val Leu Phe Ala Cys Glu Glu Tyr Ala Gln Asn Ala Leu Arg Lys His 
                245                 250                 255     


Lys Asp Leu Leu Gly Lys Arg Tyr Ile Glu Leu Phe Arg Ser Thr Ala 
            260                 265                 270         


Ala Glu Val Gln Gln Val Leu Asn Arg Phe Ser Ser Ala Pro Leu Ile 
        275                 280                 285             


Pro Leu Pro Thr Pro Pro Ile Ile Pro Val Leu Pro Gln Gln Phe Val 
    290                 295                 300                 


Pro Pro Thr Asn Val Arg Asp Cys Ile Arg Leu Arg Gly Leu Pro Tyr 
305                 310                 315                 320 


Ala Ala Thr Ile Glu Asp Ile Leu Asp Phe Leu Gly Glu Phe Ala Thr 
                325                 330                 335     


Asp Ile Arg Thr His Gly Val His Met Val Leu Asn His Gln Gly Arg 
            340                 345                 350         


Pro Ser Gly Asp Ala Phe Ile Gln Met Lys Ser Ala Asp Arg Ala Phe 
        355                 360                 365             


Met Ala Ala Gln Lys Cys His Lys Lys Asn Met Lys Asp Arg Tyr Val 
    370                 375                 380                 


Glu Val Phe Gln Cys Ser Ala Glu Glu Met Asn Phe Val Leu Met Gly 
385                 390                 395                 400 


Gly Thr Leu Asn Arg Asn Gly Leu Ser Pro Pro Pro Cys Lys Leu Pro 
                405                 410                 415     


Cys Leu Ser Pro Pro Ser Tyr Thr Phe Pro Ala Pro Ala Ala Val Ile 
            420                 425                 430         


Pro Thr Glu Ala Ala Ile Tyr Gln Pro Ser Val Ile Leu Asn Pro Arg 
        435                 440                 445             


Ala Leu Gln Pro Ser Thr Ala Tyr Tyr Pro Ala Gly Thr Gln Leu Phe 
    450                 455                 460                 


Met Asn Tyr Thr Ala Tyr Tyr Pro Ser Met Gln Pro Arg Met Asp Leu 
465                 470                 475                 480 


Tyr Thr Gln Met Thr Arg Pro Gly Leu Tyr Pro Lys Asn Gly Phe Val 
                485                 490                 495     


Phe Lys Gly Pro Ser Ser 
            500         


<210>  4933
<211>  40
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4933

Xaa Leu Leu Pro Glu Cys Phe Tyr Ser Phe Phe Asp Leu Arg Lys Glu 
1               5                   10                  15      


Phe Lys Lys Cys Cys Pro Gly Ser Pro Asp Ile Asp Lys Leu Asp Val 
            20                  25                  30          


Ala Thr Met Thr Glu Cys Ile Leu 
        35                  40  


<210>  4934
<211>  56
<212>  PRT
<213>  Homo Sapiens

<400>  4934

Met Ala Ile Lys Ser Ile Ala Ser Arg Leu Arg Gly Ser Arg Arg Phe 
1               5                   10                  15      


Leu Ser Gly Phe Val Ala Gly Ala Val Val Gly Ala Ala Gly Ala Gly 
            20                  25                  30          


Leu Ala Ala Leu Gln Phe Phe Arg Ser Gln Gly Ala Glu Gly Ala Leu 
        35                  40                  45              


Thr Gly Lys Gln Pro Asp Asp Cys 
    50                  55      


<210>  4935
<211>  56
<212>  PRT
<213>  Homo Sapiens

<400>  4935

Met Ala Ile Lys Ser Ile Ala Ser Arg Leu Arg Gly Ser Arg Arg Phe 
1               5                   10                  15      


Leu Ser Gly Phe Val Ala Gly Ala Val Val Gly Ala Ala Gly Ala Gly 
            20                  25                  30          


Leu Ala Ala Leu Gln Phe Phe Arg Ser Gln Gly Ala Glu Gly Ala Leu 
        35                  40                  45              


Thr Gly Lys Gln Pro Asp Asp Cys 
    50                  55      


<210>  4936
<211>  56
<212>  PRT
<213>  Homo Sapiens

<400>  4936

Met Ala Ile Lys Ser Ile Ala Ser Arg Leu Arg Gly Ser Arg Arg Phe 
1               5                   10                  15      


Leu Ser Gly Phe Val Ala Gly Ala Val Val Gly Ala Ala Gly Ala Gly 
            20                  25                  30          


Leu Ala Ala Leu Gln Phe Phe Arg Ser Gln Gly Ala Glu Gly Ala Leu 
        35                  40                  45              


Thr Gly Lys Gln Pro Asp Asp Cys 
    50                  55      


<210>  4937
<211>  56
<212>  PRT
<213>  Homo Sapiens

<400>  4937

Met Ala Ile Lys Ser Ile Ala Ser Arg Leu Arg Gly Ser Arg Arg Phe 
1               5                   10                  15      


Leu Ser Gly Phe Val Ala Gly Ala Val Val Gly Ala Ala Gly Ala Gly 
            20                  25                  30          


Leu Ala Ala Leu Gln Phe Phe Arg Ser Gln Gly Ala Glu Gly Ala Leu 
        35                  40                  45              


Thr Gly Lys Gln Pro Asp Asp Cys 
    50                  55      


<210>  4938
<211>  56
<212>  PRT
<213>  Homo Sapiens

<400>  4938

Met Ala Ile Lys Ser Ile Ala Ser Arg Leu Arg Gly Ser Arg Arg Phe 
1               5                   10                  15      


Leu Ser Gly Phe Val Ala Gly Ala Val Val Gly Ala Ala Gly Ala Gly 
            20                  25                  30          


Leu Ala Ala Leu Gln Phe Phe Arg Ser Gln Gly Ala Glu Gly Ala Leu 
        35                  40                  45              


Thr Gly Lys Gln Pro Asp Asp Cys 
    50                  55      


<210>  4939
<211>  318
<212>  PRT
<213>  Homo Sapiens

<400>  4939

Met Ala Ile Lys Ser Ile Ala Ser Arg Leu Arg Gly Ser Arg Arg Phe 
1               5                   10                  15      


Leu Ser Gly Phe Val Ala Gly Ala Val Val Gly Ala Ala Gly Ala Gly 
            20                  25                  30          


Leu Ala Ala Leu Gln Phe Phe Arg Ser Gln Gly Ala Glu Gly Ala Leu 
        35                  40                  45              


Thr Gly Lys Gln Pro Asp Gly Asp Ala Asp Arg Lys His Cys Lys Phe 
    50                  55                  60                  


Lys Pro Asp Pro Asn Ile Pro Pro Thr Phe Ser Ala Phe Asn Glu Asp 
65                  70                  75                  80  


Tyr Val Gly Ser Gly Trp Ser Arg Gly His Met Ala Pro Ala Gly Asn 
                85                  90                  95      


Asn Lys Phe Ser Ser Lys Ala Met Ala Glu Thr Phe Tyr Leu Ser Asn 
            100                 105                 110         


Ile Val Pro Gln Asp Phe Asp Asn Asn Ser Gly Tyr Trp Asn Arg Ile 
        115                 120                 125             


Glu Met Tyr Cys Arg Glu Leu Thr Glu Arg Phe Glu Asp Val Trp Val 
    130                 135                 140                 


Val Ser Gly Pro Leu Thr Leu Pro Gln Thr Arg Gly Asp Gly Lys Lys 
145                 150                 155                 160 


Ile Val Ser Tyr Gln Val Ile Gly Glu Asp Asn Val Ala Val Pro Ser 
                165                 170                 175     


His Leu Tyr Lys Val Ile Leu Ala Arg Arg Ser Ser Val Ser Thr Glu 
            180                 185                 190         


Pro Leu Ala Leu Gly Ala Phe Val Val Pro Asn Glu Ala Ile Gly Phe 
        195                 200                 205             


Gln Pro Gln Leu Thr Glu Phe Gln Val Ser Leu Gln Asp Leu Glu Lys 
    210                 215                 220                 


Leu Ser Gly Leu Val Phe Phe Pro His Leu Asp Arg Thr Ser Asp Ile 
225                 230                 235                 240 


Arg Asn Ile Cys Ser Val Asp Thr Cys Lys Leu Leu Asp Phe Gln Glu 
                245                 250                 255     


Phe Thr Leu Tyr Leu Ser Thr Arg Lys Ile Glu Gly Ala Arg Ser Val 
            260                 265                 270         


Leu Arg Leu Glu Lys Ile Met Glu Asn Leu Lys Asn Ala Glu Ile Glu 
        275                 280                 285             


Pro Asp Asp Tyr Phe Met Ser Arg Tyr Glu Lys Lys Leu Glu Glu Leu 
    290                 295                 300                 


Lys Ala Lys Glu Gln Ser Gly Thr Gln Ile Arg Lys Pro Ser 
305                 310                 315             


<210>  4940
<211>  368
<212>  PRT
<213>  Homo Sapiens

<400>  4940

Met Ala Ile Lys Ser Ile Ala Ser Arg Leu Arg Gly Ser Arg Arg Phe 
1               5                   10                  15      


Leu Ser Gly Phe Val Ala Gly Ala Val Val Gly Ala Ala Gly Ala Gly 
            20                  25                  30          


Leu Ala Ala Leu Gln Phe Phe Arg Ser Gln Gly Ala Glu Gly Ala Leu 
        35                  40                  45              


Thr Gly Lys Gln Pro Asp Gly Ser Ala Glu Lys Ala Val Leu Glu Gln 
    50                  55                  60                  


Phe Gly Phe Pro Leu Thr Gly Thr Glu Ala Arg Cys Tyr Thr Asn His 
65                  70                  75                  80  


Ala Leu Ser Tyr Asp Gln Ala Lys Arg Val Pro Arg Trp Val Leu Glu 
                85                  90                  95      


His Ile Ser Lys Ser Lys Ile Met Gly Asp Ala Asp Arg Lys His Cys 
            100                 105                 110         


Lys Phe Lys Pro Asp Pro Asn Ile Pro Pro Thr Phe Ser Ala Phe Asn 
        115                 120                 125             


Glu Asp Tyr Val Gly Ser Gly Trp Ser Arg Gly His Met Ala Pro Ala 
    130                 135                 140                 


Gly Asn Asn Lys Phe Ser Ser Lys Ala Met Ala Glu Thr Phe Tyr Leu 
145                 150                 155                 160 


Ser Asn Ile Val Pro Gln Asp Phe Asp Asn Asn Ser Gly Tyr Trp Asn 
                165                 170                 175     


Arg Ile Glu Met Tyr Cys Arg Glu Leu Thr Glu Arg Phe Glu Asp Val 
            180                 185                 190         


Trp Val Val Ser Gly Pro Leu Thr Leu Pro Gln Thr Arg Gly Asp Gly 
        195                 200                 205             


Lys Lys Ile Val Ser Tyr Gln Val Ile Gly Glu Asp Asn Val Ala Val 
    210                 215                 220                 


Pro Ser His Leu Tyr Lys Val Ile Leu Ala Arg Arg Ser Ser Val Ser 
225                 230                 235                 240 


Thr Glu Pro Leu Ala Leu Gly Ala Phe Val Val Pro Asn Glu Ala Ile 
                245                 250                 255     


Gly Phe Gln Pro Gln Leu Thr Glu Phe Gln Val Ser Leu Gln Asp Leu 
            260                 265                 270         


Glu Lys Leu Ser Gly Leu Val Phe Phe Pro His Leu Asp Arg Thr Ser 
        275                 280                 285             


Asp Ile Arg Asn Ile Cys Ser Val Asp Thr Cys Lys Leu Leu Asp Phe 
    290                 295                 300                 


Gln Glu Phe Thr Leu Tyr Leu Ser Thr Arg Lys Ile Glu Gly Ala Arg 
305                 310                 315                 320 


Ser Val Leu Arg Leu Glu Lys Ile Met Glu Asn Leu Lys Asn Ala Glu 
                325                 330                 335     


Ile Glu Pro Asp Asp Tyr Phe Met Ser Arg Tyr Glu Lys Lys Leu Glu 
            340                 345                 350         


Glu Leu Lys Ala Lys Glu Gln Ser Gly Thr Gln Ile Arg Lys Pro Ser 
        355                 360                 365             


<210>  4941
<211>  143
<212>  PRT
<213>  Homo Sapiens

<400>  4941

Met Ala Ile Lys Ser Ile Ala Ser Arg Leu Arg Gly Ser Arg Arg Phe 
1               5                   10                  15      


Leu Ser Gly Phe Val Ala Gly Ala Val Val Gly Ala Ala Gly Ala Gly 
            20                  25                  30          


Leu Ala Ala Leu Gln Phe Phe Arg Ser Gln Gly Ala Glu Gly Ala Leu 
        35                  40                  45              


Thr Gly Lys Gln Pro Asp Gly Ser Ala Glu Lys Ala Val Leu Glu Gln 
    50                  55                  60                  


Phe Gly Phe Pro Leu Thr Gly Thr Glu Ala Arg Cys Tyr Thr Asn His 
65                  70                  75                  80  


Ala Leu Ser Tyr Asp Gln Ala Lys Arg Val Pro Arg Trp Val Leu Glu 
                85                  90                  95      


His Ile Ser Lys Ser Lys Ile Met Gly Arg Phe Phe Lys Phe Thr Leu 
            100                 105                 110         


Leu Ala Ser Leu Phe Leu Leu Ser Leu Asn Leu His Leu Trp Leu Val 
        115                 120                 125             


Leu Asn Phe Trp Val Gln Val Thr Leu Leu Pro Gln Pro Pro Glu 
    130                 135                 140             


<210>  4942
<211>  107
<212>  PRT
<213>  Homo Sapiens

<400>  4942

Met Ala Ile Lys Ser Ile Ala Ser Arg Leu Arg Gly Ser Arg Arg Phe 
1               5                   10                  15      


Leu Ser Gly Phe Val Ala Gly Ala Val Val Gly Ala Ala Gly Ala Gly 
            20                  25                  30          


Leu Ala Ala Leu Gln Phe Phe Arg Ser Gln Gly Ala Glu Gly Ala Leu 
        35                  40                  45              


Thr Gly Lys Gln Pro Asp Gly Ser Ala Glu Lys Ala Val Leu Glu Gln 
    50                  55                  60                  


Phe Gly Phe Pro Leu Thr Gly Thr Glu Ala Arg Cys Tyr Thr Asn His 
65                  70                  75                  80  


Ala Leu Ser Tyr Asp Gln Ala Lys Arg Val Pro Arg Trp Val Leu Glu 
                85                  90                  95      


His Ile Ser Lys Ser Lys Ile Met Gly Trp Ser 
            100                 105         


<210>  4943
<211>  81
<212>  PRT
<213>  Homo Sapiens

<400>  4943

Met Ala Ile Lys Ser Ile Ala Ser Arg Leu Arg Gly Ser Arg Arg Phe 
1               5                   10                  15      


Leu Ser Gly Phe Val Ala Gly Ala Val Val Gly Ala Ala Gly Ala Gly 
            20                  25                  30          


Leu Ala Ala Leu Gln Phe Phe Arg Ser Gln Gly Ala Glu Gly Ala Leu 
        35                  40                  45              


Thr Gly Lys Gln Pro Asp Gly Ser Ala Glu Lys Ala Val Leu Glu Gln 
    50                  55                  60                  


Phe Gly Phe Pro Leu Thr Gly Thr Glu Val Asp Ser Ser Ser Leu His 
65                  70                  75                  80  


Ser 
    


<210>  4944
<211>  146
<212>  PRT
<213>  Homo Sapiens

<400>  4944

Met Ala Ile Lys Ser Ile Ala Ser Arg Leu Arg Gly Ser Arg Arg Phe 
1               5                   10                  15      


Leu Ser Gly Phe Val Ala Gly Ala Val Val Gly Ala Ala Gly Ala Gly 
            20                  25                  30          


Leu Ala Ala Leu Gln Phe Phe Arg Ser Gln Gly Ala Glu Gly Ala Leu 
        35                  40                  45              


Thr Gly Lys Gln Pro Asp Gly Ser Ala Glu Lys Ala Val Leu Glu Gln 
    50                  55                  60                  


Phe Gly Phe Pro Leu Thr Gly Thr Glu Val Met Gln Thr Glu Ser Ile 
65                  70                  75                  80  


Val Asn Leu Ser Leu Ile Pro Ile Ser Leu Gln Pro Ser Val Pro Ser 
                85                  90                  95      


Met Lys Ile Met Leu Glu Val Gly Gly His Glu Asp Thr Trp Leu Gln 
            100                 105                 110         


Gln Glu Ile Thr Asn Phe Gln Val Lys Pro Trp Leu Lys Pro Phe Thr 
        115                 120                 125             


Phe Leu Thr Leu Cys Leu Arg Ile Leu Ile Ile Ile Leu Asp Ile Gly 
    130                 135                 140                 


Thr Glu 
145     


<210>  4945
<211>  107
<212>  PRT
<213>  Homo Sapiens

<400>  4945

Arg Ser Gln Gly Ala Glu Gly Ala Leu Thr Gly Lys Gln Pro Asp Gly 
1               5                   10                  15      


Ser Ala Glu Lys Ala Val Leu Glu Gln Phe Gly Phe Pro Leu Thr Gly 
            20                  25                  30          


Thr Glu Val Met Gln Thr Glu Ser Ile Val Asn Leu Ser Leu Ile Pro 
        35                  40                  45              


Ile Ser Leu Gln Pro Ser Val Pro Ser Met Lys Ile Met Leu Glu Val 
    50                  55                  60                  


Gly Gly His Glu Asp Thr Trp Leu Gln Gln Glu Ile Thr Asn Phe Gln 
65                  70                  75                  80  


Val Lys Pro Trp Leu Lys Pro Phe Thr Phe Leu Thr Leu Cys Leu Arg 
                85                  90                  95      


Ile Leu Ile Ile Ile Leu Asp Ile Gly Thr Glu 
            100                 105         


<210>  4946
<211>  187
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4946

Xaa Phe Arg Ser Gln Gly Ala Glu Gly Ala Leu Thr Gly Lys Gln Pro 
1               5                   10                  15      


Asp Gly Ser Ala Glu Lys Ala Val Leu Glu Gln Phe Gly Phe Pro Leu 
            20                  25                  30          


Thr Gly Thr Glu Ala Arg Cys Tyr Thr Asn His Ala Leu Ser Tyr Asp 
        35                  40                  45              


Gln Ala Lys Arg Val Pro Arg Trp Val Leu Glu His Ile Ser Lys Ser 
    50                  55                  60                  


Lys Ile Met Gly Asp Ala Asp Arg Lys His Cys Lys Phe Lys Pro Asp 
65                  70                  75                  80  


Pro Asn Ile Pro Pro Thr Phe Ser Ala Phe Asn Glu Asp Tyr Val Gly 
                85                  90                  95      


Ser Gly Trp Ser Arg Gly His Met Ala Pro Ala Gly Asn Asn Lys Phe 
            100                 105                 110         


Ser Ser Lys Ala Met Ala Glu Thr Phe Tyr Leu Ser Asn Ile Val Pro 
        115                 120                 125             


Gln Asp Phe Asp Asn Asn Ser Gly Tyr Trp Asn Arg Ile Glu Met Tyr 
    130                 135                 140                 


Cys Arg Glu Leu Thr Glu Arg Phe Glu Asp Val Trp Val Val Ser Gly 
145                 150                 155                 160 


Pro Leu Thr Leu Pro Gln Thr Arg Gly Asp Gly Lys Lys Ile Val Ser 
                165                 170                 175     


Tyr Gln Ser Trp Glu Tyr Pro Ser Leu Gln Phe 
            180                 185         


<210>  4947
<211>  15
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4947

Xaa Gly Ala Glu Gly Ala Leu Thr Gly Lys Gln Pro Asp Asp Cys 
1               5                   10                  15  


<210>  4948
<211>  676
<212>  PRT
<213>  Homo Sapiens

<400>  4948

Met Gln Ser Trp Arg Arg Arg Lys Ser Leu Trp Leu Ala Leu Ser Ala 
1               5                   10                  15      


Ser Trp Leu Leu Leu Val Leu Leu Gly Gly Phe Ser Leu Leu Arg Leu 
            20                  25                  30          


Ala Leu Pro Pro Arg Pro Arg Pro Gly Ala Ser Gln Gly Trp Pro Arg 
        35                  40                  45              


Trp Leu Asp Ala Glu Leu Leu Gln Ser Phe Ser Gln Pro Gly Glu Leu 
    50                  55                  60                  


Pro Glu Asp Ala Val Ser Pro Pro Gln Ala Pro His Gly Gly Ser Cys 
65                  70                  75                  80  


Asn Trp Glu Ser Cys Phe Asp Thr Ser Lys Cys Arg Gly Asp Gly Leu 
                85                  90                  95      


Lys Val Phe Val Tyr Pro Ala Val Gly Thr Ile Ser Glu Thr His Arg 
            100                 105                 110         


Arg Ile Leu Ala Ser Ile Glu Gly Ser Arg Phe Tyr Thr Phe Ser Pro 
        115                 120                 125             


Ala Gly Ala Cys Leu Leu Leu Leu Leu Ser Leu Asp Ala Gln Thr Gly 
    130                 135                 140                 


Glu Cys Ser Ser Met Pro Leu Gln Trp Asn Arg Gly Arg Asn His Leu 
145                 150                 155                 160 


Val Leu Arg Leu His Pro Ala Pro Cys Pro Arg Thr Phe Gln Leu Gly 
                165                 170                 175     


Gln Ala Met Val Ala Glu Ala Ser Pro Thr Val Asp Ser Phe Arg Pro 
            180                 185                 190         


Gly Phe Asp Val Ala Leu Pro Phe Leu Pro Glu Ala His Pro Leu Arg 
        195                 200                 205             


Gly Gly Ala Pro Gly Gln Leu Arg Gln His Ser Pro Gln Pro Gly Val 
    210                 215                 220                 


Ala Leu Leu Ala Leu Glu Glu Glu Arg Gly Gly Trp Arg Thr Ala Asp 
225                 230                 235                 240 


Thr Gly Ser Ser Ala Cys Pro Trp Asp Gly Arg Cys Glu Gln Asp Pro 
                245                 250                 255     


Gly Pro Gly Gln Thr Gln Arg Gln Glu Thr Leu Pro Asn Ala Thr Phe 
            260                 265                 270         


Cys Leu Ile Ser Gly His Arg Pro Glu Ala Ala Ser Arg Phe Leu Gln 
        275                 280                 285             


Ala Leu Gln Ala Gly Cys Ile Pro Val Leu Leu Ser Pro Arg Trp Glu 
    290                 295                 300                 


Leu Pro Phe Ser Glu Val Ile Asp Trp Thr Lys Ala Ala Ile Val Ala 
305                 310                 315                 320 


Asp Glu Arg Leu Pro Leu Gln Val Leu Ala Ala Leu Gln Glu Met Ser 
                325                 330                 335     


Pro Ala Arg Val Leu Ala Leu Arg Gln Gln Thr Gln Phe Leu Trp Asp 
            340                 345                 350         


Ala Tyr Phe Ser Ser Val Glu Lys Val Ile His Thr Thr Leu Glu Val 
        355                 360                 365             


Ile Gln Asp Arg Ile Phe Gly Thr Ser Ala His Pro Ser Leu Leu Trp 
    370                 375                 380                 


Asn Ser Pro Pro Gly Ala Leu Leu Ala Leu Ser Thr Phe Ser Thr Ser 
385                 390                 395                 400 


Pro Gln Asp Phe Pro Phe Tyr Tyr Leu Gln Gln Gly Ser Arg Pro Glu 
                405                 410                 415     


Gly Arg Phe Ser Ala Leu Ile Trp Val Gly Pro Pro Gly Gln Pro Pro 
            420                 425                 430         


Leu Lys Leu Ile Gln Ala Val Ala Gly Ser Gln His Cys Ala Gln Ile 
        435                 440                 445             


Leu Val Leu Trp Ser Asn Glu Arg Pro Leu Pro Ser Arg Trp Pro Glu 
    450                 455                 460                 


Thr Ala Val Pro Leu Thr Val Ile Asp Gly His Arg Lys Val Ser Asp 
465                 470                 475                 480 


Arg Phe Tyr Pro Tyr Ser Thr Ile Arg Thr Asp Ala Ile Leu Ser Leu 
                485                 490                 495     


Asp Ala Arg Ser Ser Leu Ser Thr Ser Glu Val Asp Phe Ala Phe Leu 
            500                 505                 510         


Val Trp Gln Ser Phe Pro Glu Arg Met Val Gly Phe Leu Thr Ser Ser 
        515                 520                 525             


His Phe Trp Asp Glu Ala His Gly Gly Trp Gly Tyr Thr Ala Glu Arg 
    530                 535                 540                 


Thr Asn Glu Phe Ser Met Val Leu Thr Thr Ala Ala Phe Tyr His Arg 
545                 550                 555                 560 


Tyr Tyr His Thr Leu Phe Thr His Ser Leu Pro Lys Ala Leu Arg Thr 
                565                 570                 575     


Leu Ala Asp Glu Ala Pro Thr Cys Val Asp Val Leu Met Asn Phe Ile 
            580                 585                 590         


Val Ala Ala Val Thr Lys Leu Pro Pro Ile Lys Val Pro Tyr Gly Lys 
        595                 600                 605             


Gln Arg Gln Glu Ala Ala Pro Leu Ala Pro Gly Gly Pro Gly Pro Arg 
    610                 615                 620                 


Pro Lys Pro Pro Ala Pro Ala Pro Asp Cys Ile Asn Gln Ile Ala Ala 
625                 630                 635                 640 


Ala Phe Gly His Met Pro Leu Leu Ser Ser Arg Leu Arg Leu Asp Pro 
                645                 650                 655     


Val Leu Phe Lys Asp Pro Val Ser Val Gln Arg Lys Lys Tyr Arg Ser 
            660                 665                 670         


Leu Glu Lys Pro 
        675     


<210>  4949
<211>  117
<212>  PRT
<213>  Homo Sapiens

<400>  4949

Met Gly Ile Arg Val Leu Arg Leu Ser Leu Val Val Ile Leu Val Leu 
1               5                   10                  15      


Leu Leu Val Ala Gly Ala Leu Thr Ala Leu Leu Pro Ser Val Lys Glu 
            20                  25                  30          


Asp Lys Met Leu Met Leu Arg Arg Glu Ile Lys Ser Gln Gly Lys Ser 
        35                  40                  45              


Thr Met Asp Ser Phe Thr Leu Ile Met Gln Thr Tyr Asn Arg Thr Asp 
    50                  55                  60                  


Leu Leu Leu Lys Leu Leu Asn His Tyr Gln Ala Val Pro Asn Leu His 
65                  70                  75                  80  


Lys Val Ile Val Val Trp Asn Asn Ile Gly Glu Lys Ala Pro Asp Glu 
                85                  90                  95      


Leu Trp Asn Ser Leu Gly Pro His Pro Ile Pro Val Ile Phe Lys Gln 
            100                 105                 110         


Gln Thr Ala Asn Arg 
        115         


<210>  4950
<211>  147
<212>  PRT
<213>  Homo Sapiens

<400>  4950

Met Arg Cys Cys His Ile Cys Lys Leu Pro Gly Arg Val Met Gly Ile 
1               5                   10                  15      


Arg Val Leu Arg Leu Ser Leu Val Val Ile Leu Val Leu Leu Leu Val 
            20                  25                  30          


Ala Gly Ala Leu Thr Ala Leu Leu Pro Ser Val Lys Glu Asp Lys Met 
        35                  40                  45              


Leu Met Leu Arg Arg Glu Ile Lys Ser Gln Gly Lys Ser Thr Met Asp 
    50                  55                  60                  


Ser Phe Thr Leu Ile Met Gln Thr Tyr Asn Arg Thr Asp Leu Leu Leu 
65                  70                  75                  80  


Lys Leu Leu Asn His Tyr Gln Ala Val Pro Asn Leu His Lys Val Ile 
                85                  90                  95      


Val Val Trp Asn Asn Ile Gly Glu Lys Ala Pro Asp Glu Leu Trp Asn 
            100                 105                 110         


Ser Leu Gly Pro His Pro Ile Pro Val Ile Phe Lys Gln Gln Thr Ala 
        115                 120                 125             


Asn Arg Met Arg Asn Arg Leu Gln Val Phe Pro Glu Leu Glu Thr Asn 
    130                 135                 140                 


Ala Ile Ser 
145         


<210>  4951
<211>  330
<212>  PRT
<213>  Homo Sapiens

<400>  4951

Met Arg Cys Cys His Ile Cys Lys Leu Pro Gly Arg Val Met Gly Ile 
1               5                   10                  15      


Arg Val Leu Arg Leu Ser Leu Val Val Ile Leu Val Leu Leu Leu Val 
            20                  25                  30          


Ala Gly Ala Leu Thr Ala Leu Leu Pro Ser Val Lys Glu Asp Lys Met 
        35                  40                  45              


Leu Met Leu Arg Arg Glu Ile Lys Ser Gln Gly Lys Ser Thr Met Asp 
    50                  55                  60                  


Ser Phe Thr Leu Ile Met Gln Thr Tyr Asn Arg Thr Asp Leu Leu Leu 
65                  70                  75                  80  


Lys Leu Leu Asn His Tyr Gln Ala Val Pro Asn Leu His Lys Val Ile 
                85                  90                  95      


Val Val Trp Asn Asn Ile Gly Glu Lys Ala Pro Asp Glu Leu Trp Asn 
            100                 105                 110         


Ser Leu Gly Pro His Pro Ile Pro Val Ile Phe Lys Gln Gln Thr Ala 
        115                 120                 125             


Asn Arg Met Arg Asn Arg Leu Gln Val Phe Pro Glu Leu Glu Thr Asn 
    130                 135                 140                 


Ala Val Leu Met Val Asp Asp Asp Thr Leu Ile Ser Thr Pro Asp Leu 
145                 150                 155                 160 


Val Phe Ala Phe Ser Val Trp Gln Gln Phe Pro Asp Gln Ile Val Gly 
                165                 170                 175     


Phe Val Pro Arg Lys His Val Ser Thr Ser Ser Gly Ile Tyr Ser Tyr 
            180                 185                 190         


Gly Ser Phe Glu Met Gln Ala Pro Gly Ser Gly Asn Gly Asp Gln Tyr 
        195                 200                 205             


Ser Met Val Leu Ile Gly Ala Ser Phe Phe Asn Ser Lys Tyr Leu Glu 
    210                 215                 220                 


Leu Phe Gln Arg Gln Pro Ala Ala Val His Ala Leu Ile Asp Asp Thr 
225                 230                 235                 240 


Gln Asn Cys Asp Asp Ile Ala Met Asn Phe Ile Ile Ala Lys His Ile 
                245                 250                 255     


Gly Lys Thr Ser Gly Ile Phe Val Lys Pro Val Asn Met Asp Asn Leu 
            260                 265                 270         


Glu Lys Glu Thr Asn Ser Gly Tyr Ser Gly Met Trp His Arg Ala Glu 
        275                 280                 285             


His Ala Leu Gln Arg Ser Tyr Cys Ile Asn Lys Leu Val Asn Ile Tyr 
    290                 295                 300                 


Asp Ser Met Pro Leu Arg Tyr Ser Asn Ile Met Ile Ser Gln Phe Gly 
305                 310                 315                 320 


Phe Pro Tyr Ala Asn Tyr Lys Arg Lys Ile 
                325                 330 


<210>  4952
<211>  330
<212>  PRT
<213>  Homo Sapiens

<400>  4952

Met Arg Cys Cys His Ile Cys Lys Leu Pro Gly Arg Val Met Gly Ile 
1               5                   10                  15      


Arg Val Leu Arg Leu Ser Leu Val Val Ile Leu Val Leu Leu Leu Val 
            20                  25                  30          


Ala Gly Ala Leu Thr Ala Leu Leu Pro Ser Val Lys Glu Asp Lys Met 
        35                  40                  45              


Leu Met Leu Arg Arg Glu Ile Lys Ser Gln Gly Lys Ser Thr Met Asp 
    50                  55                  60                  


Ser Phe Thr Leu Ile Met Gln Thr Tyr Asn Arg Thr Asp Leu Leu Leu 
65                  70                  75                  80  


Lys Leu Leu Asn His Tyr Gln Ala Val Pro Asn Leu His Lys Val Ile 
                85                  90                  95      


Val Val Trp Asn Asn Ile Gly Glu Lys Ala Pro Asp Glu Leu Trp Asn 
            100                 105                 110         


Ser Leu Gly Pro His Pro Ile Pro Val Ile Phe Lys Gln Gln Thr Ala 
        115                 120                 125             


Asn Arg Met Arg Asn Arg Leu Gln Val Phe Pro Glu Leu Glu Thr Asn 
    130                 135                 140                 


Ala Val Leu Met Val Asp Asp Asp Thr Leu Ile Ser Thr Pro Asp Leu 
145                 150                 155                 160 


Val Phe Ala Phe Ser Val Trp Gln Gln Phe Pro Asp Gln Ile Val Gly 
                165                 170                 175     


Phe Val Pro Arg Lys His Val Ser Thr Ser Ser Gly Ile Tyr Ser Tyr 
            180                 185                 190         


Gly Ser Phe Glu Met Gln Ala Pro Gly Ser Gly Asn Gly Asp Gln Tyr 
        195                 200                 205             


Ser Met Val Leu Ile Gly Ala Ser Phe Phe Asn Ser Lys Tyr Leu Glu 
    210                 215                 220                 


Leu Phe Gln Arg Gln Pro Ala Ala Val His Ala Leu Ile Asp Asp Thr 
225                 230                 235                 240 


Gln Asn Cys Asp Asp Ile Ala Met Asn Phe Ile Ile Ala Lys His Ile 
                245                 250                 255     


Gly Lys Thr Ser Gly Ile Phe Val Lys Pro Val Asn Met Asp Asn Leu 
            260                 265                 270         


Glu Lys Glu Thr Asn Ser Gly Tyr Ser Gly Met Trp His Arg Ala Glu 
        275                 280                 285             


His Ala Leu Gln Arg Ser Tyr Cys Ile Asn Lys Leu Val Asn Ile Tyr 
    290                 295                 300                 


Asp Ser Met Pro Leu Arg Tyr Ser Asn Ile Met Ile Ser Gln Phe Gly 
305                 310                 315                 320 


Phe Pro Tyr Ala Asn Tyr Lys Arg Lys Ile 
                325                 330 


<210>  4953
<211>  266
<212>  PRT
<213>  Homo Sapiens

<400>  4953

Met Arg Thr Trp Asn Ser Gly Gly Thr Lys Cys Cys His Ile Cys Lys 
1               5                   10                  15      


Leu Pro Gly Arg Val Met Gly Ile Arg Val Leu Arg Leu Ser Leu Val 
            20                  25                  30          


Val Ile Leu Val Leu Leu Leu Val Ala Gly Ala Leu Thr Ala Leu Leu 
        35                  40                  45              


Pro Ser Val Lys Glu Asp Lys Met Leu Met Leu Arg Arg Glu Ile Lys 
    50                  55                  60                  


Ser Gln Gly Lys Ser Thr Met Asp Ser Phe Thr Leu Ile Met Gln Thr 
65                  70                  75                  80  


Tyr Asn Arg Thr Asp Leu Leu Leu Lys Leu Leu Asn His Tyr Gln Ala 
                85                  90                  95      


Val Pro Asn Leu His Lys Val Ile Val Val Trp Asn Asn Ile Gly Glu 
            100                 105                 110         


Lys Ala Pro Asp Glu Leu Trp Asn Ser Leu Gly Pro His Pro Ile Pro 
        115                 120                 125             


Val Ile Phe Lys Gln Gln Thr Ala Asn Arg Met Arg Asn Arg Leu Gln 
    130                 135                 140                 


Val Phe Pro Glu Leu Glu Thr Asn Ala Val Leu Met Val Asp Asp Asp 
145                 150                 155                 160 


Thr Leu Ile Ser Thr Pro Asp Leu Val Phe Ala Phe Ser Val Trp Gln 
                165                 170                 175     


Gln Phe Pro Asp Gln Ile Val Gly Phe Val Pro Arg Lys His Val Ser 
            180                 185                 190         


Thr Ser Ser Gly Ile Tyr Ser Tyr Gly Ser Phe Glu Met Gln Ala Pro 
        195                 200                 205             


Gly Ser Gly Asn Gly Asp Gln Tyr Ser Met Val Leu Ile Gly Ala Ser 
    210                 215                 220                 


Phe Phe Asn Ser Lys Tyr Leu Glu Leu Phe Gln Arg Gln Pro Ala Ala 
225                 230                 235                 240 


Val His Ala Leu Ile Asp Asp Thr Gln Asn Cys Asp Asp Ile Ala Met 
                245                 250                 255     


Asn Phe Ile Ile Ala Lys His Ile Gly Lys 
            260                 265     


<210>  4954
<211>  130
<212>  PRT
<213>  Homo Sapiens

<400>  4954

Met Gly Arg Pro Leu His Leu Val Leu Leu Ser Ala Ser Leu Ala Gly 
1               5                   10                  15      


Leu Leu Leu Leu Gly Glu Ser Leu Phe Ile Arg Arg Glu Gln Ala Asn 
            20                  25                  30          


Asn Ile Leu Ala Arg Val Thr Arg Ala Asn Ser Phe Leu Glu Glu Met 
        35                  40                  45              


Lys Lys Gly His Leu Glu Arg Glu Cys Met Glu Glu Thr Cys Ser Tyr 
    50                  55                  60                  


Glu Glu Ala Arg Glu Val Phe Glu Asp Ser Asp Lys Thr Asn Glu Phe 
65                  70                  75                  80  


Trp Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln 
                85                  90                  95      


Asn Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys 
            100                 105                 110         


Leu Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Cys Met Leu Ile Phe 
        115                 120                 125             


Ala Leu 
    130 


<210>  4955
<211>  334
<212>  PRT
<213>  Homo Sapiens

<400>  4955

Met Gly Arg Pro Leu His Leu Val Leu Leu Ser Ala Ser Leu Ala Gly 
1               5                   10                  15      


Leu Leu Leu Leu Gly Glu Ser Leu Phe Ile Arg Arg Glu Gln Ala Asn 
            20                  25                  30          


Asn Ile Leu Ala Arg Val Thr Arg Ala Asn Ser Phe Leu Glu Glu Met 
        35                  40                  45              


Lys Lys Gly His Leu Glu Arg Glu Cys Met Glu Glu Thr Cys Ser Tyr 
    50                  55                  60                  


Glu Glu Ala Arg Glu Val Phe Glu Asp Ser Asp Lys Thr Asn Glu Phe 
65                  70                  75                  80  


Trp Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln 
                85                  90                  95      


Asn Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys 
            100                 105                 110         


Leu Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu 
        115                 120                 125             


Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln 
    130                 135                 140                 


Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn 
145                 150                 155                 160 


Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr 
                165                 170                 175     


Leu Glu Arg Arg Lys Arg Ser Val Ala Gln Ala Thr Ser Ser Ser Gly 
            180                 185                 190         


Glu Ala Pro Asp Ser Ile Thr Trp Lys Pro Tyr Asp Ala Ala Asp Leu 
        195                 200                 205             


Asp Pro Thr Glu Asn Pro Phe Asp Leu Leu Asp Phe Asn Gln Thr Gln 
    210                 215                 220                 


Pro Glu Arg Gly Asp Asn Asn Leu Thr Arg Ile Val Gly Gly Gln Glu 
225                 230                 235                 240 


Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu 
                245                 250                 255     


Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu 
            260                 265                 270         


Thr Ala Ala His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg Gly 
        275                 280                 285             


Thr Gly Thr Arg Ser Arg Arg Arg Ala Val Arg Arg Cys Thr Arg Trp 
    290                 295                 300                 


Arg Trp Ser Ser Ser Thr Thr Gly Ser Gln Arg Arg Pro Met Thr Ser 
305                 310                 315                 320 


Thr Ser Pro Cys Ser Gly Ser Arg Pro Pro Ser Pro Ser Ala 
                325                 330                 


<210>  4956
<211>  332
<212>  PRT
<213>  Homo Sapiens

<400>  4956

Met Gly Arg Pro Leu His Leu Val Leu Leu Ser Ala Ser Leu Ala Gly 
1               5                   10                  15      


Leu Leu Leu Leu Gly Glu Ser Leu Phe Ile Arg Arg Glu Gln Ala Asn 
            20                  25                  30          


Asn Ile Leu Ala Arg Val Thr Arg Ala Asn Ser Phe Leu Glu Glu Met 
        35                  40                  45              


Lys Lys Gly His Leu Glu Arg Glu Cys Met Glu Glu Thr Cys Ser Tyr 
    50                  55                  60                  


Glu Glu Ala Arg Glu Val Phe Glu Asp Ser Asp Lys Thr Asn Glu Phe 
65                  70                  75                  80  


Trp Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln 
                85                  90                  95      


Asn Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys 
            100                 105                 110         


Leu Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu 
        115                 120                 125             


Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln 
    130                 135                 140                 


Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn 
145                 150                 155                 160 


Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr 
                165                 170                 175     


Leu Glu Arg Arg Lys Arg Ser Val Ala Gln Ala Thr Ser Ser Ser Gly 
            180                 185                 190         


Glu Ala Pro Asp Ser Ile Thr Trp Lys Pro Tyr Asp Ala Ala Asp Leu 
        195                 200                 205             


Asp Pro Thr Glu Asn Pro Phe Asp Leu Leu Asp Phe Asn Gln Thr Gln 
    210                 215                 220                 


Pro Glu Arg Gly Asp Asn Asn Leu Thr Arg Ile Val Gly Gly Gln Glu 
225                 230                 235                 240 


Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu 
                245                 250                 255     


Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu 
            260                 265                 270         


Thr Ala Ala His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Gly Thr Gly 
        275                 280                 285             


Thr Arg Ser Arg Arg Arg Ala Val Arg Arg Cys Thr Arg Trp Arg Trp 
    290                 295                 300                 


Ser Ser Ser Thr Thr Gly Ser Gln Arg Arg Pro Met Thr Ser Thr Ser 
305                 310                 315                 320 


Pro Cys Ser Gly Ser Arg Pro Pro Ser Pro Ser Ala 
                325                 330         


<210>  4957
<211>  488
<212>  PRT
<213>  Homo Sapiens

<400>  4957

Met Gly Arg Pro Leu His Leu Val Leu Leu Ser Ala Ser Leu Ala Gly 
1               5                   10                  15      


Leu Leu Leu Leu Gly Glu Ser Leu Phe Ile Arg Arg Glu Gln Ala Asn 
            20                  25                  30          


Asn Ile Leu Ala Arg Val Thr Arg Ala Asn Ser Phe Leu Glu Glu Met 
        35                  40                  45              


Lys Lys Gly His Leu Glu Arg Glu Cys Met Glu Glu Thr Cys Ser Tyr 
    50                  55                  60                  


Glu Glu Ala Arg Glu Val Phe Glu Asp Ser Asp Lys Thr Asn Glu Phe 
65                  70                  75                  80  


Trp Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln 
                85                  90                  95      


Asn Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys 
            100                 105                 110         


Leu Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu 
        115                 120                 125             


Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln 
    130                 135                 140                 


Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn 
145                 150                 155                 160 


Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr 
                165                 170                 175     


Leu Glu Arg Arg Lys Arg Ser Val Ala Gln Ala Thr Ser Ser Ser Gly 
            180                 185                 190         


Glu Ala Pro Asp Ser Ile Thr Trp Lys Pro Tyr Asp Ala Ala Asp Leu 
        195                 200                 205             


Asp Pro Thr Glu Asn Pro Phe Asp Leu Leu Asp Phe Asn Gln Thr Gln 
    210                 215                 220                 


Pro Glu Arg Gly Asp Asn Asn Leu Thr Arg Ile Val Gly Gly Gln Glu 
225                 230                 235                 240 


Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu 
                245                 250                 255     


Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu 
            260                 265                 270         


Thr Ala Ala His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg Val 
        275                 280                 285             


Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val His Glu 
    290                 295                 300                 


Val Glu Val Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr Tyr Asp 
305                 310                 315                 320 


Phe Asp Ile Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg Met 
                325                 330                 335     


Asn Val Ala Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr 
            340                 345                 350         


Leu Met Thr Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr His 
        355                 360                 365             


Glu Lys Gly Arg Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro Tyr 
    370                 375                 380                 


Val Asp Arg Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln 
385                 390                 395                 400 


Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln 
                405                 410                 415     


Gly Asp Ser Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr Tyr Phe 
            420                 425                 430         


Val Thr Gly Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys 
        435                 440                 445             


Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile Asp Arg 
    450                 455                 460                 


Ser Met Lys Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala Pro Glu 
465                 470                 475                 480 


Val Ile Thr Ser Ser Pro Leu Lys 
                485             


<210>  4958
<211>  162
<212>  PRT
<213>  Homo Sapiens

<400>  4958

Met Ile Phe Leu Tyr Gln Val Val His Phe Ile Leu Phe Thr Ser Val 
1               5                   10                  15      


Ser Gly Glu Cys Val Thr Gln Leu Leu Lys Asp Thr Cys Phe Glu Gly 
            20                  25                  30          


Gly Asp Ile Thr Thr Val Phe Thr Pro Ser Ala Lys Tyr Cys Gln Val 
        35                  40                  45              


Val Cys Thr Tyr His Pro Arg Cys Leu Leu Phe Thr Phe Thr Ala Glu 
    50                  55                  60                  


Ser Pro Ser Glu Asp Pro Thr Arg Trp Phe Thr Cys Val Leu Lys Asp 
65                  70                  75                  80  


Ser Val Thr Glu Thr Leu Pro Arg Val Asn Arg Thr Ala Ala Ile Ser 
                85                  90                  95      


Gly Tyr Ser Phe Lys Gln Cys Ser His Gln Ile Ser Ala Cys Asn Lys 
            100                 105                 110         


Asp Ile Tyr Val Asp Leu Asp Met Lys Gly Ile Asn Tyr Asn Ser Ser 
        115                 120                 125             


Val Ala Lys Ser Ala Gln Glu Cys Gln Glu Arg Cys Thr Asp Asp Val 
    130                 135                 140                 


His Cys His Phe Phe Thr Tyr Ala Thr Arg Gln Phe Pro Ser Leu Glu 
145                 150                 155                 160 


His Arg 
        


<210>  4959
<211>  625
<212>  PRT
<213>  Homo Sapiens

<400>  4959

Met Ile Phe Leu Tyr Gln Val Val His Phe Ile Leu Phe Thr Ser Val 
1               5                   10                  15      


Ser Gly Glu Cys Val Thr Gln Leu Leu Lys Asp Thr Cys Phe Glu Gly 
            20                  25                  30          


Gly Asp Ile Thr Thr Val Phe Thr Pro Ser Ala Lys Tyr Cys Gln Val 
        35                  40                  45              


Val Cys Thr Tyr His Pro Arg Cys Leu Leu Phe Thr Phe Thr Ala Glu 
    50                  55                  60                  


Ser Pro Ser Glu Asp Pro Thr Arg Trp Phe Thr Cys Val Leu Lys Asp 
65                  70                  75                  80  


Ser Val Thr Glu Thr Leu Pro Arg Val Asn Arg Thr Ala Ala Ile Ser 
                85                  90                  95      


Gly Tyr Ser Phe Lys Gln Cys Ser His Gln Ile Ser Ala Cys Asn Lys 
            100                 105                 110         


Asp Ile Tyr Val Asp Leu Asp Met Lys Gly Ile Asn Tyr Asn Ser Ser 
        115                 120                 125             


Val Ala Lys Ser Ala Gln Glu Cys Gln Glu Arg Cys Thr Asp Asp Val 
    130                 135                 140                 


His Cys His Phe Phe Thr Tyr Ala Thr Arg Gln Phe Pro Ser Leu Glu 
145                 150                 155                 160 


His Arg Asn Ile Cys Leu Leu Lys His Thr Gln Thr Gly Thr Pro Thr 
                165                 170                 175     


Arg Ile Thr Lys Leu Asp Lys Val Val Ser Gly Phe Ser Leu Lys Ser 
            180                 185                 190         


Cys Ala Leu Ser Asn Leu Ala Cys Ile Arg Asp Ile Phe Pro Asn Thr 
        195                 200                 205             


Val Phe Ala Asp Ser Asn Ile Asp Ser Val Met Ala Pro Asp Ala Phe 
    210                 215                 220                 


Val Cys Gly Arg Ile Cys Thr His His Pro Gly Cys Leu Phe Phe Thr 
225                 230                 235                 240 


Phe Phe Ser Gln Glu Trp Pro Lys Glu Ser Gln Arg Asn Leu Cys Leu 
                245                 250                 255     


Leu Lys Thr Ser Glu Ser Gly Leu Pro Ser Thr Arg Ile Lys Lys Ser 
            260                 265                 270         


Lys Ala Leu Ser Gly Phe Ser Leu Gln Ser Cys Arg His Ser Ile Pro 
        275                 280                 285             


Val Phe Cys His Ser Ser Phe Tyr His Asp Thr Asp Phe Leu Gly Glu 
    290                 295                 300                 


Glu Leu Asp Ile Val Ala Ala Lys Ser His Glu Ala Cys Gln Lys Leu 
305                 310                 315                 320 


Cys Thr Asn Ala Val Arg Cys Gln Phe Phe Thr Tyr Thr Pro Ala Gln 
                325                 330                 335     


Ala Ser Cys Asn Glu Gly Lys Gly Lys Cys Tyr Leu Lys Leu Ser Ser 
            340                 345                 350         


Asn Gly Ser Pro Thr Lys Ile Leu His Gly Arg Gly Gly Ile Ser Gly 
        355                 360                 365             


Tyr Thr Leu Arg Leu Cys Lys Met Asp Asn Glu Cys Thr Thr Lys Ile 
    370                 375                 380                 


Lys Pro Arg Ile Val Gly Gly Thr Ala Ser Val Arg Gly Glu Trp Pro 
385                 390                 395                 400 


Trp Gln Val Thr Leu His Thr Thr Ser Pro Thr Gln Arg His Leu Cys 
                405                 410                 415     


Gly Gly Ser Ile Ile Gly Asn Gln Trp Ile Leu Thr Ala Ala His Cys 
            420                 425                 430         


Phe Tyr Gly Val Glu Ser Pro Lys Ile Leu Arg Val Tyr Ser Gly Ile 
        435                 440                 445             


Leu Asn Gln Ser Glu Ile Lys Glu Asp Thr Ser Phe Phe Gly Val Gln 
    450                 455                 460                 


Glu Ile Ile Ile His Asp Gln Tyr Lys Met Ala Glu Ser Gly Tyr Asp 
465                 470                 475                 480 


Ile Ala Leu Leu Lys Leu Glu Thr Thr Val Asn Tyr Thr Asp Ser Gln 
                485                 490                 495     


Arg Pro Ile Cys Leu Pro Ser Lys Gly Asp Arg Asn Val Ile Tyr Thr 
            500                 505                 510         


Asp Cys Trp Val Thr Gly Trp Gly Tyr Arg Lys Leu Arg Asp Lys Ile 
        515                 520                 525             


Gln Asn Thr Leu Gln Lys Ala Lys Ile Pro Leu Val Thr Asn Glu Glu 
    530                 535                 540                 


Cys Gln Lys Arg Tyr Arg Gly His Lys Ile Thr His Lys Met Ile Cys 
545                 550                 555                 560 


Ala Gly Tyr Arg Glu Gly Gly Lys Asp Ala Cys Lys Gly Asp Ser Gly 
                565                 570                 575     


Gly Pro Leu Ser Cys Lys His Asn Glu Val Trp His Leu Val Gly Ile 
            580                 585                 590         


Thr Ser Trp Gly Glu Gly Cys Ala Gln Arg Glu Arg Pro Gly Val Tyr 
        595                 600                 605             


Thr Asn Val Val Glu Tyr Val Asp Trp Ile Leu Glu Lys Thr Gln Ala 
    610                 615                 620                 


Val 
625 


<210>  4960
<211>  571
<212>  PRT
<213>  Homo Sapiens

<400>  4960

Met Ile Phe Leu Tyr Gln Val Val His Phe Ile Leu Phe Thr Ser Val 
1               5                   10                  15      


Ser Gly Glu Cys Val Thr Gln Leu Leu Lys Asp Thr Cys Phe Glu Gly 
            20                  25                  30          


Gly Asp Ile Thr Thr Val Phe Thr Pro Ser Ala Lys Tyr Cys Gln Val 
        35                  40                  45              


Val Cys Thr Tyr His Pro Arg Cys Leu Leu Phe Thr Phe Thr Ala Glu 
    50                  55                  60                  


Ser Pro Ser Glu Asp Pro Thr Arg Trp Phe Thr Cys Val Leu Lys Asp 
65                  70                  75                  80  


Ser Val Thr Glu Thr Leu Pro Arg Val Asn Arg Thr Ala Ala Ile Ser 
                85                  90                  95      


Gly Tyr Ser Phe Lys Gln Cys Ser His Gln Ile Ser Asn Ile Cys Leu 
            100                 105                 110         


Leu Lys His Thr Gln Thr Gly Thr Pro Thr Arg Ile Thr Lys Leu Asp 
        115                 120                 125             


Lys Val Val Ser Gly Phe Ser Leu Lys Ser Cys Ala Leu Ser Asn Leu 
    130                 135                 140                 


Ala Cys Ile Arg Asp Ile Phe Pro Asn Thr Val Phe Ala Asp Ser Asn 
145                 150                 155                 160 


Ile Asp Ser Val Met Ala Pro Asp Ala Phe Val Cys Gly Arg Ile Cys 
                165                 170                 175     


Thr His His Pro Gly Cys Leu Phe Phe Thr Phe Phe Ser Gln Glu Trp 
            180                 185                 190         


Pro Lys Glu Ser Gln Arg Asn Leu Cys Leu Leu Lys Thr Ser Glu Ser 
        195                 200                 205             


Gly Leu Pro Ser Thr Arg Ile Lys Lys Ser Lys Ala Leu Ser Gly Phe 
    210                 215                 220                 


Ser Leu Gln Ser Cys Arg His Ser Ile Pro Val Phe Cys His Ser Ser 
225                 230                 235                 240 


Phe Tyr His Asp Thr Asp Phe Leu Gly Glu Glu Leu Asp Ile Val Ala 
                245                 250                 255     


Ala Lys Ser His Glu Ala Cys Gln Lys Leu Cys Thr Asn Ala Val Arg 
            260                 265                 270         


Cys Gln Phe Phe Thr Tyr Thr Pro Ala Gln Ala Ser Cys Asn Glu Gly 
        275                 280                 285             


Lys Gly Lys Cys Tyr Leu Lys Leu Ser Ser Asn Gly Ser Pro Thr Lys 
    290                 295                 300                 


Ile Leu His Gly Arg Gly Gly Ile Ser Gly Tyr Thr Leu Arg Leu Cys 
305                 310                 315                 320 


Lys Met Asp Asn Glu Cys Thr Thr Lys Ile Lys Pro Arg Ile Val Gly 
                325                 330                 335     


Gly Thr Ala Ser Val Arg Gly Glu Trp Pro Trp Gln Val Thr Leu His 
            340                 345                 350         


Thr Thr Ser Pro Thr Gln Arg His Leu Cys Gly Gly Ser Ile Ile Gly 
        355                 360                 365             


Asn Gln Trp Ile Leu Thr Ala Ala His Cys Phe Tyr Gly Val Glu Ser 
    370                 375                 380                 


Pro Lys Ile Leu Arg Val Tyr Ser Gly Ile Leu Asn Gln Ser Glu Ile 
385                 390                 395                 400 


Lys Glu Asp Thr Ser Phe Phe Gly Val Gln Glu Ile Ile Ile His Asp 
                405                 410                 415     


Gln Tyr Lys Met Ala Glu Ser Gly Tyr Asp Ile Ala Leu Leu Lys Leu 
            420                 425                 430         


Glu Thr Thr Val Asn Tyr Thr Asp Ser Gln Arg Pro Ile Cys Leu Pro 
        435                 440                 445             


Ser Lys Gly Asp Arg Asn Val Ile Tyr Thr Asp Cys Trp Val Thr Gly 
    450                 455                 460                 


Trp Gly Tyr Arg Lys Leu Arg Asp Lys Ile Gln Asn Thr Leu Gln Lys 
465                 470                 475                 480 


Ala Lys Ile Pro Leu Val Thr Asn Glu Glu Cys Gln Lys Arg Tyr Arg 
                485                 490                 495     


Gly His Lys Ile Thr His Lys Met Ile Cys Ala Gly Tyr Arg Glu Gly 
            500                 505                 510         


Gly Lys Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro Leu Ser Cys Lys 
        515                 520                 525             


His Asn Glu Val Trp His Leu Val Gly Ile Thr Ser Trp Gly Glu Gly 
    530                 535                 540                 


Cys Ala Gln Arg Glu Arg Pro Gly Val Tyr Thr Asn Val Val Glu Tyr 
545                 550                 555                 560 


Val Asp Trp Ile Leu Glu Lys Thr Gln Ala Val 
                565                 570     


<210>  4961
<211>  210
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4961

Xaa Ser Gly Phe Ser Leu Lys Ser Cys Ala Leu Ser Asn Leu Ala Cys 
1               5                   10                  15      


Ile Arg Asp Ile Phe Pro Asn Thr Val Phe Ala Asp Ser Asn Ile Asp 
            20                  25                  30          


Ser Val Met Ala Pro Asp Ala Phe Val Cys Gly Arg Ile Cys Thr His 
        35                  40                  45              


His Pro Gly Cys Leu Phe Phe Thr Phe Phe Ser Gln Glu Trp Pro Lys 
    50                  55                  60                  


Glu Ser Gln Arg Asn Leu Cys Leu Leu Lys Thr Ser Glu Ser Gly Leu 
65                  70                  75                  80  


Pro Ser Thr Arg Ile Lys Lys Ser Lys Ala Leu Ser Gly Phe Ser Leu 
                85                  90                  95      


Gln Ser Cys Arg His Ser Ile Pro Val Phe Cys His Ser Ser Phe Tyr 
            100                 105                 110         


His Asp Thr Asp Phe Leu Gly Glu Glu Leu Asp Ile Val Ala Ala Lys 
        115                 120                 125             


Ser His Glu Ala Cys Gln Lys Leu Cys Thr Asn Ala Val Arg Cys Gln 
    130                 135                 140                 


Phe Phe Thr Tyr Thr Pro Ala Gln Ala Ser Cys Asn Glu Gly Lys Gly 
145                 150                 155                 160 


Lys Cys Tyr Leu Lys Leu Ser Ser Asn Gly Ser Pro Thr Lys Ile Leu 
                165                 170                 175     


His Gly Arg Gly Gly Ile Ser Gly Tyr Thr Leu Arg Leu Cys Lys Met 
            180                 185                 190         


Asp Asn Glu Leu Arg Gly Ala Pro Met Lys Ile Ser Gly Trp Leu Lys 
        195                 200                 205             


Thr Ser 
    210 


<210>  4962
<211>  159
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  4962

Xaa Val Glu Ser Pro Lys Ile Leu Arg Val Tyr Ser Gly Ile Leu Asn 
1               5                   10                  15      


Gln Ser Glu Ile Lys Glu Asp Thr Ser Phe Phe Gly Val Gln Glu Ile 
            20                  25                  30          


Ile Ile His Asp Gln Tyr Lys Met Ala Glu Ser Gly Tyr Asp Ile Ala 
        35                  40                  45              


Leu Leu Lys Leu Glu Thr Thr Val Asn Tyr Thr Asp Lys Ile Gln Asn 
    50                  55                  60                  


Thr Leu Gln Lys Ala Lys Ile Pro Leu Val Thr Asn Glu Glu Cys Gln 
65                  70                  75                  80  


Lys Arg Tyr Arg Gly His Lys Ile Thr His Lys Met Ile Cys Ala Gly 
                85                  90                  95      


Tyr Arg Glu Gly Gly Lys Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro 
            100                 105                 110         


Leu Ser Cys Lys His Asn Glu Val Trp His Leu Val Gly Ile Thr Ser 
        115                 120                 125             


Trp Gly Glu Gly Cys Ala Gln Arg Glu Arg Pro Gly Val Tyr Thr Asn 
    130                 135                 140                 


Val Val Glu Tyr Val Asp Trp Ile Leu Glu Lys Thr Gln Ala Val 
145                 150                 155                 


<210>  4963
<211>  615
<212>  PRT
<213>  Homo Sapiens

<400>  4963

Met Arg Ala Leu Leu Leu Leu Gly Phe Leu Leu Val Ser Leu Glu Ser 
1               5                   10                  15      


Thr Leu Ser Ile Pro Pro Trp Glu Ala Pro Lys Glu His Lys Tyr Lys 
            20                  25                  30          


Ala Glu Glu His Thr Val Val Leu Thr Val Thr Gly Glu Pro Cys His 
        35                  40                  45              


Phe Pro Phe Gln Tyr His Arg Gln Leu Tyr His Lys Cys Thr His Lys 
    50                  55                  60                  


Gly Arg Pro Gly Pro Gln Pro Trp Cys Ala Thr Thr Pro Asn Phe Asp 
65                  70                  75                  80  


Gln Asp Gln Arg Trp Gly Tyr Cys Leu Glu Pro Lys Lys Val Lys Asp 
                85                  90                  95      


His Cys Ser Lys His Ser Pro Cys Gln Lys Gly Gly Thr Cys Val Asn 
            100                 105                 110         


Met Pro Ser Gly Pro His Cys Leu Cys Pro Gln His Leu Thr Gly Asn 
        115                 120                 125             


His Cys Gln Lys Glu Lys Cys Phe Glu Pro Gln Leu Leu Arg Phe Phe 
    130                 135                 140                 


His Lys Asn Glu Ile Trp Tyr Arg Thr Glu Gln Ala Ala Val Ala Arg 
145                 150                 155                 160 


Cys Gln Cys Lys Gly Pro Asp Ala His Cys Gln Arg Leu Ala Ser Gln 
                165                 170                 175     


Ala Cys Arg Thr Asn Pro Cys Leu His Gly Gly Arg Cys Leu Glu Val 
            180                 185                 190         


Glu Gly His Arg Leu Cys His Cys Pro Val Gly Tyr Thr Gly Ala Phe 
        195                 200                 205             


Cys Asp Val Asp Thr Lys Ala Ser Cys Tyr Asp Gly Arg Gly Leu Ser 
    210                 215                 220                 


Tyr Arg Gly Leu Ala Arg Thr Thr Leu Ser Gly Ala Pro Cys Gln Pro 
225                 230                 235                 240 


Trp Ala Ser Glu Ala Thr Tyr Arg Asn Val Thr Ala Glu Gln Ala Arg 
                245                 250                 255     


Asn Trp Gly Leu Gly Gly His Ala Phe Cys Arg Asn Pro Asp Asn Asp 
            260                 265                 270         


Ile Arg Pro Trp Cys Phe Val Leu Asn Arg Asp Arg Leu Ser Trp Glu 
        275                 280                 285             


Tyr Cys Asp Leu Ala Gln Cys Gln Thr Pro Thr Gln Ala Ala Pro Pro 
    290                 295                 300                 


Thr Pro Val Ser Pro Arg Leu His Val Pro Leu Met Pro Ala Gln Pro 
305                 310                 315                 320 


Ala Pro Pro Lys Pro Gln Pro Thr Thr Arg Thr Pro Pro Gln Ser Gln 
                325                 330                 335     


Thr Pro Gly Ala Leu Pro Ala Lys Arg Glu Gln Pro Pro Ser Leu Thr 
            340                 345                 350         


Arg Asn Gly Pro Leu Ser Cys Gly Gln Arg Leu Arg Lys Ser Leu Ser 
        355                 360                 365             


Ser Met Thr Arg Val Val Gly Gly Leu Val Ala Leu Arg Gly Ala His 
    370                 375                 380                 


Pro Tyr Ile Ala Ala Leu Tyr Trp Gly His Ser Phe Cys Ala Gly Ser 
385                 390                 395                 400 


Leu Ile Ala Pro Cys Trp Val Leu Thr Ala Ala His Cys Leu Gln Asp 
                405                 410                 415     


Arg Pro Ala Pro Glu Asp Leu Thr Val Val Leu Gly Gln Glu Arg Arg 
            420                 425                 430         


Asn His Ser Cys Glu Pro Cys Gln Thr Leu Ala Val Arg Ser Tyr Arg 
        435                 440                 445             


Leu His Glu Ala Phe Ser Pro Val Ser Tyr Gln His Asp Leu Ala Leu 
    450                 455                 460                 


Leu Arg Leu Gln Glu Asp Ala Asp Gly Ser Cys Ala Leu Leu Ser Pro 
465                 470                 475                 480 


Tyr Val Gln Pro Val Cys Leu Pro Ser Gly Ala Ala Arg Pro Ser Glu 
                485                 490                 495     


Thr Thr Leu Cys Gln Val Ala Gly Trp Gly His Gln Phe Glu Gly Ala 
            500                 505                 510         


Glu Glu Tyr Ala Ser Phe Leu Gln Glu Ala Gln Val Pro Phe Leu Ser 
        515                 520                 525             


Leu Glu Arg Cys Ser Ala Pro Asp Val His Gly Ser Ser Ile Leu Pro 
    530                 535                 540                 


Gly Met Leu Cys Ala Gly Phe Leu Glu Gly Gly Thr Asp Ala Cys Gln 
545                 550                 555                 560 


Gly Asp Ser Gly Gly Pro Leu Val Cys Glu Asp Gln Ala Ala Glu Arg 
                565                 570                 575     


Arg Leu Thr Leu Gln Gly Ile Ile Ser Trp Gly Ser Gly Cys Gly Asp 
            580                 585                 590         


Arg Asn Lys Pro Gly Val Tyr Thr Asp Val Ala Tyr Tyr Leu Ala Trp 
        595                 600                 605             


Ile Arg Glu His Thr Val Ser 
    610                 615 


<210>  4964
<211>  661
<212>  PRT
<213>  Homo Sapiens

<400>  4964

Met Arg Leu Lys Asn Leu Thr Phe Ile Ile Ile Leu Ile Ile Ser Gly 
1               5                   10                  15      


Glu Leu Tyr Ala Glu Glu Lys Pro Cys Gly Phe Pro His Val Glu Asn 
            20                  25                  30          


Gly Arg Ile Ala Gln Tyr Tyr Tyr Thr Phe Lys Ser Phe Tyr Phe Pro 
        35                  40                  45              


Met Ser Ile Asp Lys Lys Leu Ser Phe Phe Cys Leu Ala Gly Tyr Thr 
    50                  55                  60                  


Thr Glu Ser Gly Arg Gln Glu Glu Gln Thr Thr Cys Thr Thr Glu Gly 
65                  70                  75                  80  


Trp Ser Pro Glu Pro Arg Cys Phe Lys Lys Cys Thr Lys Pro Asp Leu 
                85                  90                  95      


Ser Asn Gly Tyr Ile Ser Asp Val Lys Leu Leu Tyr Lys Ile Gln Glu 
            100                 105                 110         


Asn Met Arg Tyr Gly Cys Ala Ser Gly Tyr Lys Thr Thr Gly Gly Lys 
        115                 120                 125             


Asp Glu Glu Val Val Gln Cys Leu Ser Asp Gly Trp Ser Ser Gln Pro 
    130                 135                 140                 


Thr Cys Arg Lys Glu His Glu Thr Cys Leu Ala Pro Glu Leu Tyr Asn 
145                 150                 155                 160 


Gly Asn Tyr Ser Thr Thr Gln Lys Thr Phe Lys Val Lys Asp Lys Val 
                165                 170                 175     


Gln Tyr Glu Cys Ala Thr Gly Tyr Tyr Thr Ala Gly Gly Lys Lys Thr 
            180                 185                 190         


Glu Glu Val Glu Cys Leu Thr Tyr Gly Trp Ser Leu Thr Pro Lys Cys 
        195                 200                 205             


Thr Lys Leu Lys Cys Ser Ser Leu Arg Leu Ile Glu Asn Gly Tyr Phe 
    210                 215                 220                 


His Pro Val Lys Gln Thr Tyr Glu Glu Gly Asp Val Val Gln Phe Phe 
225                 230                 235                 240 


Cys His Glu Asn Tyr Tyr Leu Ser Gly Ser Asp Leu Ile Gln Cys Tyr 
                245                 250                 255     


Asn Phe Gly Trp Tyr Pro Glu Ser Pro Val Cys Glu Gly Arg Arg Asn 
            260                 265                 270         


Arg Cys Pro Pro Pro Pro Leu Pro Ile Asn Ser Lys Ile Gln Thr His 
        275                 280                 285             


Ser Thr Thr Tyr Arg His Gly Glu Ile Val His Ile Glu Cys Glu Leu 
    290                 295                 300                 


Asn Phe Glu Ile His Gly Ser Ala Glu Ile Arg Cys Glu Asp Gly Lys 
305                 310                 315                 320 


Trp Thr Glu Pro Pro Lys Cys Ile Glu Gly Gln Glu Lys Val Ala Cys 
                325                 330                 335     


Glu Glu Pro Pro Phe Ile Glu Asn Gly Ala Ala Asn Leu His Ser Lys 
            340                 345                 350         


Ile Tyr Tyr Asn Gly Asp Lys Val Thr Tyr Ala Cys Lys Ser Gly Tyr 
        355                 360                 365             


Leu Leu His Gly Ser Asn Glu Ile Thr Cys Asn Arg Gly Lys Trp Thr 
    370                 375                 380                 


Leu Pro Pro Glu Cys Val Glu Asn Asn Glu Asn Cys Lys His Pro Pro 
385                 390                 395                 400 


Val Val Met Asn Gly Ala Val Ala Asp Gly Ile Leu Ala Ser Tyr Ala 
                405                 410                 415     


Thr Gly Ser Ser Val Glu Tyr Arg Cys Asn Glu Tyr Tyr Leu Leu Arg 
            420                 425                 430         


Gly Ser Lys Ile Ser Arg Cys Glu Gln Gly Lys Trp Ser Ser Pro Pro 
        435                 440                 445             


Val Cys Leu Glu Pro Cys Thr Val Asn Val Asp Tyr Met Asn Arg Asn 
    450                 455                 460                 


Asn Ile Glu Met Lys Trp Lys Tyr Glu Gly Lys Val Leu His Gly Asp 
465                 470                 475                 480 


Leu Ile Asp Phe Val Cys Lys Gln Gly Tyr Asp Leu Ser Pro Leu Thr 
                485                 490                 495     


Pro Leu Ser Glu Leu Ser Val Gln Cys Asn Arg Gly Glu Val Lys Tyr 
            500                 505                 510         


Pro Leu Cys Thr Arg Lys Glu Ser Lys Gly Met Cys Thr Ser Pro Pro 
        515                 520                 525             


Leu Ile Lys His Gly Val Ile Ile Ser Ser Thr Val Asp Thr Tyr Glu 
    530                 535                 540                 


Asn Gly Ser Ser Val Glu Tyr Arg Cys Phe Asp His His Phe Leu Glu 
545                 550                 555                 560 


Gly Ser Arg Glu Ala Tyr Cys Leu Asp Gly Met Trp Thr Thr Pro Pro 
                565                 570                 575     


Leu Cys Leu Glu Pro Cys Thr Leu Ser Phe Thr Glu Met Glu Lys Asn 
            580                 585                 590         


Asn Leu Leu Leu Lys Trp Asp Phe Asp Asn Arg Pro His Ile Leu His 
        595                 600                 605             


Gly Glu Tyr Ile Glu Phe Ile Cys Arg Gly Asp Thr Tyr Pro Ala Glu 
    610                 615                 620                 


Leu Tyr Ile Thr Gly Ser Ile Leu Arg Met Gln Cys Asp Arg Gly Gln 
625                 630                 635                 640 


Leu Lys Tyr Pro Arg Cys Ile Pro Arg Gln Ser Thr Leu Ser Tyr Gln 
                645                 650                 655     


Glu Pro Leu Arg Thr 
            660     


<210>  4965
<211>  622
<212>  PRT
<213>  Homo Sapiens

<400>  4965

Met Ala His Val Arg Gly Leu Gln Leu Pro Gly Cys Leu Ala Leu Ala 
1               5                   10                  15      


Ala Leu Cys Ser Leu Val His Ser Gln His Val Phe Leu Ala Pro Gln 
            20                  25                  30          


Gln Ala Arg Ser Leu Leu Gln Arg Val Arg Arg Ala Asn Thr Phe Leu 
        35                  40                  45              


Glu Glu Val Arg Lys Gly Asn Leu Glu Arg Glu Cys Val Glu Glu Thr 
    50                  55                  60                  


Cys Ser Tyr Glu Glu Ala Phe Glu Ala Leu Glu Ser Ser Thr Ala Thr 
65                  70                  75                  80  


Asp Val Phe Trp Ala Lys Tyr Thr Ala Cys Glu Thr Ala Arg Thr Pro 
                85                  90                  95      


Arg Asp Lys Leu Ala Ala Cys Leu Glu Gly Asn Cys Ala Glu Gly Leu 
            100                 105                 110         


Gly Thr Asn Tyr Arg Gly His Val Asn Ile Thr Arg Ser Gly Ile Glu 
        115                 120                 125             


Cys Gln Leu Trp Arg Ser Arg Tyr Pro His Lys Pro Glu Ile Asn Ser 
    130                 135                 140                 


Thr Thr His Pro Gly Ala Asp Leu Gln Glu Asn Phe Cys Arg Asn Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Thr Gly Pro Trp Cys Tyr Thr Thr Asp Pro Thr Val 
                165                 170                 175     


Arg Arg Gln Glu Cys Ser Ile Pro Val Cys Gly Gln Asp Gln Val Thr 
            180                 185                 190         


Val Ala Met Thr Pro Arg Ser Glu Gly Ser Ser Val Asn Leu Ser Pro 
        195                 200                 205             


Pro Leu Glu Gln Cys Val Pro Asp Arg Gly Gln Gln Tyr Gln Gly Arg 
    210                 215                 220                 


Leu Ala Val Thr Thr His Gly Leu Pro Cys Leu Ala Trp Ala Ser Ala 
225                 230                 235                 240 


Gln Ala Lys Ala Leu Ser Lys His Gln Asp Phe Asn Ser Ala Val Gln 
                245                 250                 255     


Leu Val Glu Asn Phe Cys Arg Asn Pro Asp Gly Asp Glu Glu Gly Val 
            260                 265                 270         


Trp Cys Tyr Val Ala Gly Lys Pro Gly Asp Phe Gly Tyr Cys Asp Leu 
        275                 280                 285             


Asn Tyr Cys Glu Glu Ala Val Glu Glu Glu Thr Gly Asp Gly Leu Asp 
    290                 295                 300                 


Glu Asp Ser Asp Arg Ala Ile Glu Gly Arg Thr Ala Thr Ser Glu Tyr 
305                 310                 315                 320 


Gln Thr Phe Phe Asn Pro Arg Thr Phe Gly Ser Gly Glu Ala Asp Cys 
                325                 330                 335     


Gly Leu Arg Pro Leu Phe Glu Lys Lys Ser Leu Glu Asp Lys Thr Glu 
            340                 345                 350         


Arg Glu Leu Leu Glu Ser Tyr Ile Asp Gly Arg Ile Val Glu Gly Ser 
        355                 360                 365             


Asp Ala Glu Ile Gly Met Ser Pro Trp Gln Val Met Leu Phe Arg Lys 
    370                 375                 380                 


Ser Pro Gln Glu Leu Leu Cys Gly Ala Ser Leu Ile Ser Asp Arg Trp 
385                 390                 395                 400 


Val Leu Thr Ala Ala His Cys Leu Leu Tyr Pro Pro Trp Asp Lys Asn 
                405                 410                 415     


Phe Thr Glu Asn Asp Leu Leu Val Arg Ile Gly Lys His Ser Arg Thr 
            420                 425                 430         


Arg Tyr Glu Arg Asn Ile Glu Lys Ile Ser Met Leu Glu Lys Ile Tyr 
        435                 440                 445             


Ile His Pro Arg Tyr Asn Trp Arg Glu Asn Leu Asp Arg Asp Ile Ala 
    450                 455                 460                 


Leu Met Lys Leu Lys Lys Pro Val Ala Phe Ser Asp Tyr Ile His Pro 
465                 470                 475                 480 


Val Cys Leu Pro Asp Arg Glu Thr Ala Ala Ser Leu Leu Gln Ala Gly 
                485                 490                 495     


Tyr Lys Gly Arg Val Thr Gly Trp Gly Asn Leu Lys Glu Thr Trp Thr 
            500                 505                 510         


Ala Asn Val Gly Lys Gly Gln Pro Ser Val Leu Gln Val Val Asn Leu 
        515                 520                 525             


Pro Ile Val Glu Arg Pro Val Cys Lys Asp Ser Thr Arg Ile Arg Ile 
    530                 535                 540                 


Thr Asp Asn Met Phe Cys Ala Gly Tyr Lys Pro Asp Glu Gly Lys Arg 
545                 550                 555                 560 


Gly Asp Ala Cys Glu Gly Asp Ser Gly Gly Pro Phe Val Met Lys Ser 
                565                 570                 575     


Pro Phe Asn Asn Arg Trp Tyr Gln Met Gly Ile Val Ser Trp Gly Glu 
            580                 585                 590         


Gly Cys Asp Arg Asp Gly Lys Tyr Gly Phe Tyr Thr His Val Phe Arg 
        595                 600                 605             


Leu Lys Lys Trp Ile Gln Lys Val Ile Asp Gln Phe Gly Glu 
    610                 615                 620         


<210>  4966
<211>  583
<212>  PRT
<213>  Homo Sapiens

<400>  4966

Met Ala His Val Arg Gly Leu Gln Leu Pro Gly Cys Leu Ala Leu Ala 
1               5                   10                  15      


Ala Leu Cys Ser Leu Val His Ser Gln His Val Phe Leu Ala Pro Gln 
            20                  25                  30          


Gln Ala Arg Ser Leu Leu Gln Arg Val Arg Arg Ala Asn Thr Phe Leu 
        35                  40                  45              


Glu Glu Val Arg Lys Gly Asn Leu Glu Arg Glu Cys Val Glu Glu Thr 
    50                  55                  60                  


Cys Ser Tyr Glu Glu Ala Phe Glu Ala Leu Glu Ser Ser Thr Ala Thr 
65                  70                  75                  80  


Asp Val Phe Trp Ala Lys Tyr Thr Ala Cys Glu Thr Ala Arg Thr Pro 
                85                  90                  95      


Arg Asp Lys Leu Ala Ala Cys Leu Glu Gly Asn Cys Ala Glu Gly Leu 
            100                 105                 110         


Gly Thr Asn Tyr Arg Gly His Val Asn Ile Thr Arg Ser Gly Ile Glu 
        115                 120                 125             


Cys Gln Leu Trp Arg Ser Arg Tyr Pro His Lys Pro Glu Ile Asn Ser 
    130                 135                 140                 


Thr Thr His Pro Gly Ala Asp Leu Gln Glu Asn Phe Cys Arg Asn Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Thr Gly Pro Trp Cys Tyr Thr Thr Asp Pro Thr Val 
                165                 170                 175     


Arg Arg Gln Glu Cys Ser Ile Pro Val Cys Gly Gln Asp Gln Val Thr 
            180                 185                 190         


Val Ala Met Thr Pro Arg Ser Glu Gly Ser Ser Val Asn Leu Ser Pro 
        195                 200                 205             


Pro Leu Glu Gln Cys Val Pro Asp Arg Gly Gln Gln Tyr Gln Gly Arg 
    210                 215                 220                 


Leu Ala Val Thr Thr His Gly Leu Pro Cys Leu Ala Trp Ala Ser Ala 
225                 230                 235                 240 


Gln Ala Lys Ala Leu Ser Lys His Gln Asp Phe Asn Ser Ala Val Gln 
                245                 250                 255     


Leu Val Glu Asn Phe Cys Arg Asn Pro Asp Gly Asp Glu Glu Gly Val 
            260                 265                 270         


Trp Cys Tyr Val Ala Gly Lys Pro Gly Asp Phe Gly Tyr Cys Asp Leu 
        275                 280                 285             


Asn Tyr Cys Glu Glu Ala Val Glu Glu Glu Thr Gly Asp Gly Leu Asp 
    290                 295                 300                 


Glu Asp Ser Asp Arg Ala Ile Glu Gly Arg Thr Ala Thr Ser Glu Tyr 
305                 310                 315                 320 


Gln Thr Phe Phe Asn Pro Arg Thr Phe Gly Ser Gly Glu Ala Asp Cys 
                325                 330                 335     


Gly Leu Arg Pro Leu Phe Glu Lys Lys Ser Leu Glu Asp Lys Thr Glu 
            340                 345                 350         


Arg Glu Leu Leu Glu Ser Tyr Ile Asp Gly Arg Ile Val Glu Gly Ser 
        355                 360                 365             


Asp Ala Glu Ile Gly Met Ser Pro Trp Gln Val Met Leu Phe Arg Lys 
    370                 375                 380                 


Ser Pro Gln Glu Leu Leu Cys Gly Ala Ser Leu Ile Ser Asp Arg Trp 
385                 390                 395                 400 


Val Leu Thr Ala Ala His Cys Leu Leu Tyr Pro Pro Trp Asp Lys Asn 
                405                 410                 415     


Phe Thr Glu Asn Asp Leu Leu Val Arg Ile Gly Lys His Ser Arg Thr 
            420                 425                 430         


Arg Tyr Glu Arg Asn Ile Glu Lys Ile Ser Met Leu Glu Lys Ile Tyr 
        435                 440                 445             


Ile His Pro Ser Leu Leu Gln Ala Gly Tyr Lys Gly Arg Val Thr Gly 
    450                 455                 460                 


Trp Gly Asn Leu Lys Glu Thr Trp Thr Ala Asn Val Gly Lys Gly Gln 
465                 470                 475                 480 


Pro Ser Val Leu Gln Val Val Asn Leu Pro Ile Val Glu Arg Pro Val 
                485                 490                 495     


Cys Lys Asp Ser Thr Arg Ile Arg Ile Thr Asp Asn Met Phe Cys Ala 
            500                 505                 510         


Gly Tyr Lys Pro Asp Glu Gly Lys Arg Gly Asp Ala Cys Glu Gly Asp 
        515                 520                 525             


Ser Gly Gly Pro Phe Val Met Lys Ser Pro Phe Asn Asn Arg Trp Tyr 
    530                 535                 540                 


Gln Met Gly Ile Val Ser Trp Gly Glu Gly Cys Asp Arg Asp Gly Lys 
545                 550                 555                 560 


Tyr Gly Phe Tyr Thr His Val Phe Arg Leu Lys Lys Trp Ile Gln Lys 
                565                 570                 575     


Val Ile Asp Gln Phe Gly Glu 
            580             


<210>  4967
<211>  324
<212>  PRT
<213>  Homo Sapiens

<400>  4967

Met Gly Trp Gly Leu Leu Ala Gly Gln Ser Thr Gln Ser Trp Pro Leu 
1               5                   10                  15      


Met Phe Leu Ala Pro Gln Gln Ala Arg Ser Leu Leu Gln Arg Val Arg 
            20                  25                  30          


Arg Ala Asn Thr Phe Leu Glu Glu Val Arg Lys Gly Asn Leu Glu Arg 
        35                  40                  45              


Glu Cys Val Glu Glu Thr Cys Ser Tyr Glu Glu Ala Phe Glu Ala Leu 
    50                  55                  60                  


Glu Ser Ser Thr Ala Thr Asp Val Phe Trp Ala Lys Tyr Thr Ala Cys 
65                  70                  75                  80  


Glu Thr Ala Arg Thr Pro Arg Asp Lys Leu Ala Ala Cys Leu Glu Gly 
                85                  90                  95      


Asn Cys Ala Glu Gly Leu Gly Thr Asn Tyr Arg Gly His Val Asn Ile 
            100                 105                 110         


Thr Arg Ser Gly Ile Glu Cys Gln Leu Trp Arg Ser Arg Tyr Pro His 
        115                 120                 125             


Lys Pro Glu Ile Asn Ser Thr Thr His Pro Gly Ala Asp Leu Gln Glu 
    130                 135                 140                 


Asn Phe Cys Arg Asn Pro Asp Ser Ser Thr Thr Gly Pro Trp Cys Tyr 
145                 150                 155                 160 


Thr Thr Asp Pro Thr Val Arg Arg Gln Glu Cys Ser Ile Pro Val Cys 
                165                 170                 175     


Gly Gln Asp Gln Val Thr Val Ala Met Thr Pro Arg Ser Glu Gly Ser 
            180                 185                 190         


Ser Val Asn Leu Ser Pro Pro Leu Glu Gln Cys Val Pro Asp Arg Gly 
        195                 200                 205             


Gln Gln Tyr Gln Gly Arg Leu Ala Val Thr Thr His Gly Leu Pro Cys 
    210                 215                 220                 


Leu Ala Trp Ala Ser Ala Gln Ala Lys Ala Leu Ser Lys His Gln Asp 
225                 230                 235                 240 


Phe Asn Ser Ala Val Gln Leu Val Glu Asn Phe Cys Arg Asn Pro Asp 
                245                 250                 255     


Gly Asp Glu Glu Gly Val Trp Cys Tyr Val Ala Gly Lys Pro Gly Asp 
            260                 265                 270         


Phe Gly Tyr Cys Asp Leu Asn Tyr Cys Glu Glu Ala Val Glu Glu Glu 
        275                 280                 285             


Thr Gly Asp Gly Leu Asp Glu Asp Ser Asp Arg Ala Ile Glu Gly Arg 
    290                 295                 300                 


Thr Ala Thr Ser Glu Tyr Gln Thr Phe Phe Asn Pro Arg Thr Phe Gly 
305                 310                 315                 320 


Ser Gly Glu Ala 
                


<210>  4968
<211>  425
<212>  PRT
<213>  Homo Sapiens

<400>  4968

Met Gly Pro Arg Arg Leu Leu Leu Val Ala Ala Cys Phe Ser Leu Cys 
1               5                   10                  15      


Gly Pro Leu Leu Ser Ala Arg Thr Arg Ala Arg Arg Pro Glu Ser Lys 
            20                  25                  30          


Ala Thr Asn Ala Thr Leu Asp Pro Arg Ser Phe Leu Leu Arg Asn Pro 
        35                  40                  45              


Asn Asp Lys Tyr Glu Pro Phe Trp Glu Asp Glu Glu Lys Asn Glu Ser 
    50                  55                  60                  


Gly Leu Thr Glu Tyr Arg Leu Val Ser Ile Asn Lys Ser Ser Pro Leu 
65                  70                  75                  80  


Gln Lys Gln Leu Pro Ala Phe Ile Ser Glu Asp Ala Ser Gly Tyr Leu 
                85                  90                  95      


Thr Ser Ser Trp Leu Thr Leu Phe Val Pro Ser Val Tyr Thr Gly Val 
            100                 105                 110         


Phe Val Val Ser Leu Pro Leu Asn Ile Met Ala Ile Val Val Phe Ile 
        115                 120                 125             


Leu Lys Met Lys Val Lys Lys Pro Ala Val Val Tyr Met Leu His Leu 
    130                 135                 140                 


Ala Thr Ala Asp Val Leu Phe Val Ser Val Leu Pro Phe Lys Ile Ser 
145                 150                 155                 160 


Tyr Tyr Phe Ser Gly Ser Asp Trp Gln Phe Gly Ser Glu Leu Cys Arg 
                165                 170                 175     


Phe Val Thr Ala Ala Phe Tyr Cys Asn Met Tyr Ala Ser Ile Leu Leu 
            180                 185                 190         


Met Thr Val Ile Ser Ile Asp Arg Phe Leu Ala Val Val Tyr Pro Met 
        195                 200                 205             


Gln Ser Leu Ser Trp Arg Thr Leu Gly Arg Ala Ser Phe Thr Cys Leu 
    210                 215                 220                 


Ala Ile Trp Ala Leu Ala Ile Ala Gly Val Val Pro Leu Leu Leu Lys 
225                 230                 235                 240 


Glu Gln Thr Ile Gln Val Pro Gly Leu Asn Ile Thr Thr Cys His Asp 
                245                 250                 255     


Val Leu Asn Glu Thr Leu Leu Glu Gly Tyr Tyr Ala Tyr Tyr Phe Ser 
            260                 265                 270         


Ala Phe Ser Ala Val Phe Phe Phe Val Pro Leu Ile Ile Ser Thr Val 
        275                 280                 285             


Cys Tyr Val Ser Ile Ile Arg Cys Leu Ser Ser Ser Ala Val Ala Asn 
    290                 295                 300                 


Arg Ser Lys Lys Ser Arg Ala Leu Phe Leu Ser Ala Ala Val Phe Cys 
305                 310                 315                 320 


Ile Phe Ile Ile Cys Phe Gly Pro Thr Asn Val Leu Leu Ile Ala His 
                325                 330                 335     


Tyr Ser Phe Leu Ser His Thr Ser Thr Thr Glu Ala Ala Tyr Phe Ala 
            340                 345                 350         


Tyr Leu Leu Cys Val Cys Val Ser Ser Ile Ser Cys Cys Ile Asp Pro 
        355                 360                 365             


Leu Ile Tyr Tyr Tyr Ala Ser Ser Glu Cys Gln Arg Tyr Val Tyr Ser 
    370                 375                 380                 


Ile Leu Cys Cys Lys Glu Ser Ser Asp Pro Ser Ser Tyr Asn Ser Ser 
385                 390                 395                 400 


Gly Gln Leu Met Ala Ser Lys Met Asp Thr Cys Ser Ser Asn Leu Asn 
                405                 410                 415     


Asn Ser Ile Tyr Lys Lys Leu Leu Thr 
            420                 425 


<210>  4969
<211>  102
<212>  PRT
<213>  Homo Sapiens

<400>  4969

Met Gly Pro Arg Arg Leu Leu Leu Val Ala Ala Cys Phe Ser Leu Cys 
1               5                   10                  15      


Gly Pro Leu Leu Ser Ala Arg Thr Arg Ala Arg Arg Pro Val Thr Phe 
            20                  25                  30          


Arg Trp Gly Val Pro Pro Pro Ser Arg Ala Gln Pro Met Pro Leu Trp 
        35                  40                  45              


Thr Arg Ser Trp Arg Val Gln Pro Ala Cys His Gly Val Leu Asp Met 
    50                  55                  60                  


Glu Glu Asp Gly Ala Glu Ala Pro Trp Gly Ser Leu Gln Ser Cys Val 
65                  70                  75                  80  


Ala Leu Val Ile Val Phe Leu Pro Gly Pro Pro Pro Lys Arg Lys Ala 
                85                  90                  95      


Leu Thr Leu Leu His Gln 
            100         


<210>  4970
<211>  113
<212>  PRT
<213>  Homo Sapiens

<400>  4970

Met Trp Gly Arg Leu Leu Leu Trp Pro Leu Val Leu Gly Phe Ser Leu 
1               5                   10                  15      


Ser Gly Gly Thr Gln Thr Pro Ser Val Tyr Asp Glu Ser Gly Ser Thr 
            20                  25                  30          


Gly Gly Gly Asp Ala Arg Pro Gln Ser Cys Leu Pro Pro Ala Ala Thr 
        35                  40                  45              


Gln Ala Lys Ser Val Pro Met Thr Val Thr Pro Trp Ser Ser Arg Thr 
    50                  55                  60                  


Ala His Gly His Cys Phe Trp Ala Gly Cys Pro Pro Gly Trp Cys Pro 
65                  70                  75                  80  


Pro Ser Met Gly Trp Ser Trp Trp Trp Gly Cys Arg Pro Met Gly Trp 
                85                  90                  95      


Arg Cys Gly Cys Trp Pro Arg Arg His Leu Gly Cys Pro Pro Pro Cys 
            100                 105                 110         


Cys 
    


<210>  4971
<211>  385
<212>  PRT
<213>  Homo Sapiens

<400>  4971

Met Trp Gly Arg Leu Leu Leu Trp Pro Leu Val Leu Gly Phe Ser Leu 
1               5                   10                  15      


Ser Gly Gly Thr Gln Thr Pro Ser Val Tyr Asp Glu Ser Gly Ser Thr 
            20                  25                  30          


Gly Gly Gly Asp Asp Ser Thr Pro Ser Ile Leu Pro Ala Pro Arg Gly 
        35                  40                  45              


Tyr Pro Gly Gln Val Cys Ala Asn Asp Ser Asp Thr Leu Glu Leu Pro 
    50                  55                  60                  


Asp Ser Ser Arg Ala Leu Leu Leu Gly Trp Val Pro Thr Arg Leu Val 
65                  70                  75                  80  


Pro Ala Leu Tyr Gly Leu Val Leu Val Val Gly Leu Pro Ala Asn Gly 
                85                  90                  95      


Leu Ala Leu Trp Val Leu Ala Thr Gln Ala Pro Arg Leu Pro Ser Thr 
            100                 105                 110         


Met Leu Leu Met Asn Leu Ala Ala Ala Asp Leu Leu Leu Ala Leu Ala 
        115                 120                 125             


Leu Pro Pro Arg Ile Ala Tyr His Leu Arg Gly Gln Arg Trp Pro Phe 
    130                 135                 140                 


Gly Glu Ala Ala Cys Arg Leu Ala Thr Ala Ala Leu Tyr Gly His Met 
145                 150                 155                 160 


Tyr Gly Ser Val Leu Leu Leu Ala Ala Val Ser Leu Asp Arg Tyr Leu 
                165                 170                 175     


Ala Leu Val His Pro Leu Arg Ala Arg Ala Leu Arg Gly Arg Arg Leu 
            180                 185                 190         


Ala Leu Gly Leu Cys Met Ala Ala Trp Leu Met Ala Ala Ala Leu Ala 
        195                 200                 205             


Leu Pro Leu Thr Leu Gln Arg Gln Thr Phe Arg Leu Ala Arg Ser Asp 
    210                 215                 220                 


Arg Val Leu Cys His Asp Ala Leu Pro Leu Asp Ala Gln Ala Ser His 
225                 230                 235                 240 


Trp Gln Pro Ala Phe Thr Cys Leu Ala Leu Leu Gly Cys Phe Leu Pro 
                245                 250                 255     


Leu Leu Ala Met Leu Leu Cys Tyr Gly Ala Thr Leu His Thr Leu Ala 
            260                 265                 270         


Ala Ser Gly Arg Arg Tyr Gly His Ala Leu Arg Leu Thr Ala Val Val 
        275                 280                 285             


Leu Ala Ser Ala Val Ala Phe Phe Val Pro Ser Asn Leu Leu Leu Leu 
    290                 295                 300                 


Leu His Tyr Ser Asp Pro Ser Pro Ser Ala Trp Gly Asn Leu Tyr Gly 
305                 310                 315                 320 


Ala Tyr Val Pro Ser Leu Ala Leu Ser Thr Leu Asn Ser Cys Val Asp 
                325                 330                 335     


Pro Phe Ile Tyr Tyr Tyr Val Ser Ala Glu Phe Arg Asp Lys Val Arg 
            340                 345                 350         


Ala Gly Leu Phe Gln Arg Ser Pro Gly Asp Thr Val Ala Ser Lys Ala 
        355                 360                 365             


Ser Ala Glu Gly Gly Ser Arg Gly Met Gly Thr His Ser Ser Leu Leu 
    370                 375                 380                 


Gln 
385 


<210>  4972
<211>  2224
<212>  PRT
<213>  Homo Sapiens

<400>  4972

Met Phe Pro Gly Cys Pro Arg Leu Trp Val Leu Val Val Leu Gly Thr 
1               5                   10                  15      


Ser Trp Val Gly Trp Gly Ser Gln Gly Thr Glu Ala Ala Gln Leu Arg 
            20                  25                  30          


Gln Phe Tyr Val Ala Ala Gln Gly Ile Ser Trp Ser Tyr Arg Pro Glu 
        35                  40                  45              


Pro Thr Asn Ser Ser Leu Asn Leu Ser Val Thr Ser Phe Lys Lys Ile 
    50                  55                  60                  


Val Tyr Arg Glu Tyr Glu Pro Tyr Phe Lys Lys Glu Lys Pro Gln Ser 
65                  70                  75                  80  


Thr Ile Ser Gly Leu Leu Gly Pro Thr Leu Tyr Ala Glu Val Gly Asp 
                85                  90                  95      


Ile Ile Lys Val His Phe Lys Asn Lys Ala Asp Lys Pro Leu Ser Ile 
            100                 105                 110         


His Pro Gln Gly Ile Arg Tyr Ser Lys Leu Ser Glu Gly Ala Ser Tyr 
        115                 120                 125             


Leu Asp His Thr Phe Pro Ala Glu Lys Met Asp Asp Ala Val Ala Pro 
    130                 135                 140                 


Gly Arg Glu Tyr Thr Tyr Glu Trp Ser Ile Ser Glu Asp Ser Gly Pro 
145                 150                 155                 160 


Thr His Asp Asp Pro Pro Cys Leu Thr His Ile Tyr Tyr Ser His Glu 
                165                 170                 175     


Asn Leu Ile Glu Asp Phe Asn Ser Gly Leu Ile Gly Pro Leu Leu Ile 
            180                 185                 190         


Cys Lys Lys Gly Thr Leu Thr Glu Gly Gly Thr Gln Lys Thr Phe Asp 
        195                 200                 205             


Lys Gln Ile Val Leu Leu Phe Ala Val Phe Asp Glu Ser Lys Ser Trp 
    210                 215                 220                 


Ser Gln Ser Ser Ser Leu Met Tyr Thr Val Asn Gly Tyr Val Asn Gly 
225                 230                 235                 240 


Thr Met Pro Asp Ile Thr Val Cys Ala His Asp His Ile Ser Trp His 
                245                 250                 255     


Leu Leu Gly Met Ser Ser Gly Pro Glu Leu Phe Ser Ile His Phe Asn 
            260                 265                 270         


Gly Gln Val Leu Glu Gln Asn His His Lys Val Ser Ala Ile Thr Leu 
        275                 280                 285             


Val Ser Ala Thr Ser Thr Thr Ala Asn Met Thr Val Gly Pro Glu Gly 
    290                 295                 300                 


Lys Trp Ile Ile Ser Ser Leu Thr Pro Lys His Leu Gln Ala Gly Met 
305                 310                 315                 320 


Gln Ala Tyr Ile Asp Ile Lys Asn Cys Pro Lys Lys Thr Arg Asn Leu 
                325                 330                 335     


Lys Lys Ile Thr Arg Glu Gln Arg Arg His Met Lys Arg Trp Glu Tyr 
            340                 345                 350         


Phe Ile Ala Ala Glu Glu Val Ile Trp Asp Tyr Ala Pro Val Ile Pro 
        355                 360                 365             


Ala Asn Met Asp Lys Lys Tyr Arg Ser Gln His Leu Asp Asn Phe Ser 
    370                 375                 380                 


Asn Gln Ile Gly Lys His Tyr Lys Lys Val Met Tyr Thr Gln Tyr Glu 
385                 390                 395                 400 


Asp Glu Ser Phe Thr Lys His Thr Val Asn Pro Asn Met Lys Glu Asp 
                405                 410                 415     


Gly Ile Leu Gly Pro Ile Ile Arg Ala Gln Val Arg Asp Thr Leu Lys 
            420                 425                 430         


Ile Val Phe Lys Asn Met Ala Ser Arg Pro Tyr Ser Ile Tyr Pro His 
        435                 440                 445             


Gly Val Thr Phe Ser Pro Tyr Glu Asp Glu Val Asn Ser Ser Phe Thr 
    450                 455                 460                 


Ser Gly Arg Asn Asn Thr Met Ile Arg Ala Val Gln Pro Gly Glu Thr 
465                 470                 475                 480 


Tyr Thr Tyr Lys Trp Asn Ile Leu Glu Phe Asp Glu Pro Thr Glu Asn 
                485                 490                 495     


Asp Ala Gln Cys Leu Thr Arg Pro Tyr Tyr Ser Asp Val Asp Ile Met 
            500                 505                 510         


Arg Asp Ile Ala Ser Gly Leu Ile Gly Leu Leu Leu Ile Cys Lys Ser 
        515                 520                 525             


Arg Ser Leu Asp Arg Arg Gly Ile Gln Arg Ala Ala Asp Ile Glu Gln 
    530                 535                 540                 


Gln Ala Val Phe Ala Val Phe Asp Glu Asn Lys Ser Trp Tyr Leu Glu 
545                 550                 555                 560 


Asp Asn Ile Asn Lys Phe Cys Glu Asn Pro Asp Glu Val Lys Arg Asp 
                565                 570                 575     


Asp Pro Lys Phe Tyr Glu Ser Asn Ile Met Ser Thr Ile Asn Gly Tyr 
            580                 585                 590         


Val Pro Glu Ser Ile Thr Thr Leu Gly Phe Cys Phe Asp Asp Thr Val 
        595                 600                 605             


Gln Trp His Phe Cys Ser Val Gly Thr Gln Asn Glu Ile Leu Thr Ile 
    610                 615                 620                 


His Phe Thr Gly His Ser Phe Ile Tyr Gly Lys Arg His Glu Asp Thr 
625                 630                 635                 640 


Leu Thr Leu Phe Pro Met Arg Gly Glu Ser Val Thr Val Thr Met Asp 
                645                 650                 655     


Asn Val Gly Thr Trp Met Leu Thr Ser Met Asn Ser Ser Pro Arg Ser 
            660                 665                 670         


Lys Lys Leu Arg Leu Lys Phe Arg Asp Val Lys Cys Ile Pro Asp Asp 
        675                 680                 685             


Asp Glu Asp Ser Tyr Glu Ile Phe Glu Pro Pro Glu Ser Thr Val Met 
    690                 695                 700                 


Ala Thr Arg Lys Met His Asp Arg Leu Glu Pro Glu Asp Glu Glu Ser 
705                 710                 715                 720 


Asp Ala Asp Tyr Asp Tyr Gln Asn Arg Leu Ala Ala Ala Leu Gly Ile 
                725                 730                 735     


Arg Ser Phe Arg Asn Ser Ser Leu Asn Gln Glu Glu Glu Glu Phe Asn 
            740                 745                 750         


Leu Thr Ala Leu Ala Leu Glu Asn Gly Thr Glu Phe Val Ser Ser Asn 
        755                 760                 765             


Thr Asp Ile Ile Val Gly Ser Asn Tyr Ser Ser Pro Ser Asn Ile Ser 
    770                 775                 780                 


Lys Phe Thr Val Asn Asn Leu Ala Glu Pro Gln Lys Ala Pro Ser His 
785                 790                 795                 800 


Gln Gln Ala Thr Thr Ala Gly Ser Pro Leu Arg His Leu Ile Gly Lys 
                805                 810                 815     


Asn Ser Val Leu Asn Ser Ser Thr Ala Glu His Ser Ser Pro Tyr Ser 
            820                 825                 830         


Glu Asp Pro Ile Glu Asp Pro Leu Gln Pro Asp Val Thr Gly Ile Arg 
        835                 840                 845             


Leu Leu Ser Leu Gly Ala Gly Glu Phe Lys Ser Gln Glu His Ala Lys 
    850                 855                 860                 


His Lys Gly Pro Lys Val Glu Arg Asp Gln Ala Ala Lys His Arg Phe 
865                 870                 875                 880 


Ser Trp Met Lys Leu Leu Ala His Lys Val Gly Arg His Leu Ser Gln 
                885                 890                 895     


Asp Thr Gly Ser Pro Ser Gly Met Arg Pro Trp Glu Asp Leu Pro Ser 
            900                 905                 910         


Gln Asp Thr Gly Ser Pro Ser Arg Met Arg Pro Trp Lys Asp Pro Pro 
        915                 920                 925             


Ser Asp Leu Leu Leu Leu Lys Gln Ser Asn Ser Ser Lys Ile Leu Val 
    930                 935                 940                 


Gly Arg Trp His Leu Ala Ser Glu Lys Gly Ser Tyr Glu Ile Ile Gln 
945                 950                 955                 960 


Asp Thr Asp Glu Asp Thr Ala Val Asn Asn Trp Leu Ile Ser Pro Gln 
                965                 970                 975     


Asn Ala Ser Arg Ala Trp Gly Glu Ser Thr Pro Leu Ala Asn Lys Pro 
            980                 985                 990         


Gly Lys Gln Ser Gly His Pro Lys  Phe Pro Arg Val Arg  His Lys Ser 
        995                 1000                 1005             


Leu Gln  Val Arg Gln Asp Gly  Gly Lys Ser Arg Leu  Lys Lys Ser 
    1010                 1015                 1020             


Gln Phe  Leu Ile Lys Thr Arg  Lys Lys Lys Lys Glu  Lys His Thr 
    1025                 1030                 1035             


His His  Ala Pro Leu Ser Pro  Arg Thr Phe His Pro  Leu Arg Ser 
    1040                 1045                 1050             


Glu Ala  Tyr Asn Thr Phe Ser  Glu Arg Arg Leu Lys  His Ser Leu 
    1055                 1060                 1065             


Val Leu  His Lys Ser Asn Glu  Thr Ser Leu Pro Thr  Asp Leu Asn 
    1070                 1075                 1080             


Gln Thr  Leu Pro Ser Met Asp  Phe Gly Trp Ile Ala  Ser Leu Pro 
    1085                 1090                 1095             


Asp His  Asn Gln Asn Ser Ser  Asn Asp Thr Gly Gln  Ala Ser Cys 
    1100                 1105                 1110             


Pro Pro  Gly Leu Tyr Gln Thr  Val Pro Pro Glu Glu  His Tyr Gln 
    1115                 1120                 1125             


Thr Phe  Pro Ile Gln Asp Pro  Asp Gln Met His Ser  Thr Ser Asp 
    1130                 1135                 1140             


Pro Ser  His Arg Ser Ser Ser  Pro Glu Leu Ser Glu  Met Leu Glu 
    1145                 1150                 1155             


Tyr Asp  Arg Ser His Lys Ser  Phe Pro Thr Asp Ile  Ser Gln Met 
    1160                 1165                 1170             


Ser Pro  Ser Ser Glu His Glu  Val Trp Gln Thr Val  Ile Ser Pro 
    1175                 1180                 1185             


Asp Leu  Ser Gln Val Thr Leu  Ser Pro Glu Leu Ser  Gln Thr Asn 
    1190                 1195                 1200             


Leu Ser  Pro Asp Leu Ser His  Thr Thr Leu Ser Pro  Glu Leu Ile 
    1205                 1210                 1215             


Gln Arg  Asn Leu Ser Pro Ala  Leu Gly Gln Met Pro  Ile Ser Pro 
    1220                 1225                 1230             


Asp Leu  Ser His Thr Thr Leu  Ser Pro Asp Leu Ser  His Thr Thr 
    1235                 1240                 1245             


Leu Ser  Leu Asp Leu Ser Gln  Thr Asn Leu Ser Pro  Glu Leu Ser 
    1250                 1255                 1260             


Gln Thr  Asn Leu Ser Pro Ala  Leu Gly Gln Met Pro  Leu Ser Pro 
    1265                 1270                 1275             


Asp Leu  Ser His Thr Thr Leu  Ser Leu Asp Phe Ser  Gln Thr Asn 
    1280                 1285                 1290             


Leu Ser  Pro Glu Leu Ser His  Met Thr Leu Ser Pro  Glu Leu Ser 
    1295                 1300                 1305             


Gln Thr  Asn Leu Ser Pro Ala  Leu Gly Gln Met Pro  Ile Ser Pro 
    1310                 1315                 1320             


Asp Leu  Ser His Thr Thr Leu  Ser Leu Asp Phe Ser  Gln Thr Asn 
    1325                 1330                 1335             


Leu Ser  Pro Glu Leu Ser Gln  Thr Asn Leu Ser Pro  Ala Leu Gly 
    1340                 1345                 1350             


Gln Met  Pro Leu Ser Pro Asp  Pro Ser His Thr Thr  Leu Ser Leu 
    1355                 1360                 1365             


Asp Leu  Ser Gln Thr Asn Leu  Ser Pro Glu Leu Ser  Gln Thr Asn 
    1370                 1375                 1380             


Leu Ser  Pro Asp Leu Ser Glu  Met Pro Leu Phe Ala  Asp Leu Ser 
    1385                 1390                 1395             


Gln Ile  Pro Leu Thr Pro Asp  Leu Asp Gln Met Thr  Leu Ser Pro 
    1400                 1405                 1410             


Asp Leu  Gly Glu Thr Asp Leu  Ser Pro Asn Phe Gly  Gln Met Ser 
    1415                 1420                 1425             


Leu Ser  Pro Asp Leu Ser Gln  Val Thr Leu Ser Pro  Asp Ile Ser 
    1430                 1435                 1440             


Asp Thr  Thr Leu Leu Pro Asp  Leu Ser Gln Ile Ser  Pro Pro Pro 
    1445                 1450                 1455             


Asp Leu  Asp Gln Ile Phe Tyr  Pro Ser Glu Ser Ser  Gln Ser Leu 
    1460                 1465                 1470             


Leu Leu  Gln Glu Phe Asn Glu  Ser Phe Pro Tyr Pro  Asp Leu Gly 
    1475                 1480                 1485             


Gln Met  Pro Ser Pro Ser Ser  Pro Thr Leu Asn Asp  Thr Phe Leu 
    1490                 1495                 1500             


Ser Lys  Glu Phe Asn Pro Leu  Val Ile Val Gly Leu  Ser Lys Asp 
    1505                 1510                 1515             


Gly Thr  Asp Tyr Ile Glu Ile  Ile Pro Lys Glu Glu  Val Gln Ser 
    1520                 1525                 1530             


Ser Glu  Asp Asp Tyr Ala Glu  Ile Asp Tyr Val Pro  Tyr Asp Asp 
    1535                 1540                 1545             


Pro Tyr  Lys Thr Asp Val Arg  Thr Asn Ile Asn Ser  Ser Arg Asp 
    1550                 1555                 1560             


Pro Asp  Asn Ile Ala Ala Trp  Tyr Leu Arg Ser Asn  Asn Gly Asn 
    1565                 1570                 1575             


Arg Arg  Asn Tyr Tyr Ile Ala  Ala Glu Glu Ile Ser  Trp Asp Tyr 
    1580                 1585                 1590             


Ser Glu  Phe Val Gln Arg Glu  Thr Asp Ile Glu Asp  Ser Asp Asp 
    1595                 1600                 1605             


Ile Pro  Glu Asp Thr Thr Tyr  Lys Lys Val Val Phe  Arg Lys Tyr 
    1610                 1615                 1620             


Leu Asp  Ser Thr Phe Thr Lys  Arg Asp Pro Arg Gly  Glu Tyr Glu 
    1625                 1630                 1635             


Glu His  Leu Gly Ile Leu Gly  Pro Ile Ile Arg Ala  Glu Val Asp 
    1640                 1645                 1650             


Asp Val  Ile Gln Val Arg Phe  Lys Asn Leu Ala Ser  Arg Pro Tyr 
    1655                 1660                 1665             


Ser Leu  His Ala His Gly Leu  Ser Tyr Glu Lys Ser  Ser Glu Gly 
    1670                 1675                 1680             


Lys Thr  Tyr Glu Asp Asp Ser  Pro Glu Trp Phe Lys  Glu Asp Asn 
    1685                 1690                 1695             


Ala Val  Gln Pro Asn Ser Ser  Tyr Thr Tyr Val Trp  His Ala Thr 
    1700                 1705                 1710             


Glu Arg  Ser Gly Pro Glu Ser  Pro Gly Ser Ala Cys  Arg Ala Trp 
    1715                 1720                 1725             


Ala Tyr  Tyr Ser Ala Val Asn  Pro Glu Lys Asp Ile  His Ser Gly 
    1730                 1735                 1740             


Leu Ile  Gly Pro Leu Leu Ile  Cys Gln Lys Gly Ile  Leu His Lys 
    1745                 1750                 1755             


Asp Ser  Asn Met Pro Met Asp  Met Arg Glu Phe Val  Leu Leu Phe 
    1760                 1765                 1770             


Met Thr  Phe Asp Glu Lys Lys  Ser Trp Tyr Tyr Glu  Lys Lys Ser 
    1775                 1780                 1785             


Arg Ser  Ser Trp Arg Leu Thr  Ser Ser Glu Met Lys  Lys Ser His 
    1790                 1795                 1800             


Glu Phe  His Ala Ile Asn Gly  Met Ile Tyr Ser Leu  Pro Gly Leu 
    1805                 1810                 1815             


Lys Met  Tyr Glu Gln Glu Trp  Val Arg Leu His Leu  Leu Asn Ile 
    1820                 1825                 1830             


Gly Gly  Ser Gln Asp Ile His  Val Val His Phe His  Gly Gln Thr 
    1835                 1840                 1845             


Leu Leu  Glu Asn Gly Asn Lys  Gln His Gln Leu Gly  Val Trp Pro 
    1850                 1855                 1860             


Leu Leu  Pro Gly Ser Phe Lys  Thr Leu Glu Met Lys  Ala Ser Lys 
    1865                 1870                 1875             


Pro Gly  Trp Trp Leu Leu Asn  Thr Glu Val Gly Glu  Asn Gln Arg 
    1880                 1885                 1890             


Ala Gly  Met Gln Thr Pro Phe  Leu Ile Met Asp Arg  Asp Cys Arg 
    1895                 1900                 1905             


Met Pro  Met Gly Leu Ser Thr  Gly Ile Ile Ser Asp  Ser Gln Ile 
    1910                 1915                 1920             


Lys Ala  Ser Glu Phe Leu Gly  Tyr Trp Glu Pro Arg  Leu Ala Arg 
    1925                 1930                 1935             


Leu Asn  Asn Gly Gly Ser Tyr  Asn Ala Trp Ser Val  Glu Lys Leu 
    1940                 1945                 1950             


Ala Ala  Glu Phe Ala Ser Lys  Pro Trp Ile Gln Val  Asp Met Gln 
    1955                 1960                 1965             


Lys Glu  Val Ile Ile Thr Gly  Ile Gln Thr Gln Gly  Ala Lys His 
    1970                 1975                 1980             


Tyr Leu  Lys Ser Cys Tyr Thr  Thr Glu Phe Tyr Val  Ala Tyr Ser 
    1985                 1990                 1995             


Ser Asn  Gln Ile Asn Trp Gln  Ile Phe Lys Gly Asn  Ser Thr Arg 
    2000                 2005                 2010             


Asn Val  Met Tyr Phe Asn Gly  Asn Ser Asp Ala Ser  Thr Ile Lys 
    2015                 2020                 2025             


Glu Asn  Gln Phe Asp Pro Pro  Ile Val Ala Arg Tyr  Ile Arg Ile 
    2030                 2035                 2040             


Ser Pro  Thr Arg Ala Tyr Asn  Arg Pro Thr Leu Arg  Leu Glu Leu 
    2045                 2050                 2055             


Gln Gly  Cys Glu Val Asn Gly  Cys Ser Thr Pro Leu  Gly Met Glu 
    2060                 2065                 2070             


Asn Gly  Lys Ile Glu Asn Lys  Gln Ile Thr Ala Ser  Ser Phe Lys 
    2075                 2080                 2085             


Lys Ser  Trp Trp Gly Asp Tyr  Trp Glu Pro Phe Arg  Ala Arg Leu 
    2090                 2095                 2100             


Asn Ala  Gln Gly Arg Val Asn  Ala Trp Gln Ala Lys  Ala Asn Asn 
    2105                 2110                 2115             


Asn Lys  Gln Trp Leu Glu Ile  Asp Leu Leu Lys Ile  Lys Lys Ile 
    2120                 2125                 2130             


Thr Ala  Ile Ile Thr Gln Gly  Cys Lys Ser Leu Ser  Ser Glu Met 
    2135                 2140                 2145             


Tyr Val  Lys Ser Tyr Thr Ile  His Tyr Ser Glu Gln  Gly Val Glu 
    2150                 2155                 2160             


Trp Lys  Pro Tyr Arg Leu Lys  Ser Ser Met Val Asp  Lys Ile Phe 
    2165                 2170                 2175             


Glu Gly  Asn Thr Asn Thr Lys  Gly His Val Lys Asn  Phe Phe Asn 
    2180                 2185                 2190             


Pro Pro  Ile Ile Ser Arg Phe  Ile Arg Val Ile Pro  Lys Thr Trp 
    2195                 2200                 2205             


Asn Gln  Ser Ile Ala Leu Arg  Leu Glu Leu Phe Gly  Cys Asp Ile 
    2210                 2215                 2220             


Tyr 
    


<210>  4973
<211>  2229
<212>  PRT
<213>  Homo Sapiens

<400>  4973

Met Phe Pro Gly Cys Pro Arg Leu Trp Val Leu Val Val Leu Gly Thr 
1               5                   10                  15      


Ser Trp Val Gly Trp Gly Ser Gln Gly Thr Glu Ala Ala Gln Leu Arg 
            20                  25                  30          


Gln Phe Tyr Val Ala Ala Gln Gly Ile Ser Trp Ser Tyr Arg Pro Glu 
        35                  40                  45              


Pro Thr Asn Ser Ser Leu Asn Leu Ser Val Thr Ser Phe Lys Lys Ile 
    50                  55                  60                  


Val Tyr Arg Glu Tyr Glu Pro Tyr Phe Lys Lys Glu Lys Pro Gln Ser 
65                  70                  75                  80  


Thr Ile Ser Gly Leu Leu Gly Pro Thr Leu Tyr Ala Glu Val Gly Asp 
                85                  90                  95      


Ile Ile Lys Val His Phe Lys Asn Lys Ala Asp Lys Pro Leu Ser Ile 
            100                 105                 110         


His Pro Gln Gly Ile Arg Tyr Ser Lys Leu Ser Glu Gly Ala Ser Tyr 
        115                 120                 125             


Leu Asp His Thr Phe Pro Ala Glu Lys Met Asp Asp Ala Val Ala Pro 
    130                 135                 140                 


Gly Arg Glu Tyr Thr Tyr Glu Trp Ser Ile Ser Glu Asp Ser Gly Pro 
145                 150                 155                 160 


Thr His Asp Asp Pro Pro Cys Leu Thr His Ile Tyr Tyr Ser His Glu 
                165                 170                 175     


Asn Leu Ile Glu Asp Phe Asn Ser Gly Leu Ile Gly Pro Leu Leu Ile 
            180                 185                 190         


Cys Lys Lys Gly Thr Leu Thr Glu Gly Gly Thr Gln Lys Thr Phe Asp 
        195                 200                 205             


Lys Gln Ile Val Leu Leu Phe Ala Val Phe Asp Glu Ser Lys Ser Trp 
    210                 215                 220                 


Ser Gln Ser Ser Ser Leu Met Tyr Thr Val Asn Gly Tyr Val Asn Gly 
225                 230                 235                 240 


Thr Met Pro Asp Ile Thr Val Cys Ala His Asp His Ile Ser Trp His 
                245                 250                 255     


Leu Leu Gly Met Ser Ser Gly Pro Glu Leu Phe Ser Ile His Phe Asn 
            260                 265                 270         


Gly Gln Val Leu Glu Gln Asn His His Lys Val Ser Ala Ile Thr Leu 
        275                 280                 285             


Val Ser Ala Thr Ser Thr Thr Ala Asn Met Thr Val Gly Pro Glu Gly 
    290                 295                 300                 


Lys Trp Ile Ile Ser Ser Leu Thr Pro Lys His Leu Gln Ala Gly Met 
305                 310                 315                 320 


Gln Ala Tyr Ile Asp Ile Lys Asn Cys Pro Lys Lys Thr Arg Asn Leu 
                325                 330                 335     


Lys Lys Ile Thr Arg Glu Gln Arg Arg His Met Lys Arg Trp Glu Tyr 
            340                 345                 350         


Phe Ile Ala Ala Glu Glu Val Ile Trp Asp Tyr Ala Pro Val Ile Pro 
        355                 360                 365             


Ala Asn Met Asp Lys Lys Tyr Arg Ser Gln His Leu Asp Asn Phe Ser 
    370                 375                 380                 


Asn Gln Ile Gly Lys His Tyr Lys Lys Val Met Tyr Thr Gln Tyr Glu 
385                 390                 395                 400 


Asp Glu Ser Phe Thr Lys His Thr Val Asn Pro Asn Met Lys Glu Asp 
                405                 410                 415     


Gly Ile Leu Gly Pro Ile Ile Arg Ala Gln Val Arg Asp Thr Leu Lys 
            420                 425                 430         


Ile Val Phe Lys Asn Met Ala Ser Arg Pro Tyr Ser Ile Tyr Pro His 
        435                 440                 445             


Gly Val Thr Phe Ser Pro Tyr Glu Asp Glu Val Asn Ser Ser Phe Thr 
    450                 455                 460                 


Ser Gly Arg Asn Asn Thr Met Ile Arg Ala Val Gln Pro Gly Glu Thr 
465                 470                 475                 480 


Tyr Thr Tyr Lys Trp Asn Ile Leu Glu Phe Asp Glu Pro Thr Glu Asn 
                485                 490                 495     


Asp Ala Gln Cys Leu Thr Arg Pro Tyr Tyr Ser Asp Val Asp Ile Met 
            500                 505                 510         


Arg Asp Ile Ala Ser Gly Leu Ile Gly Leu Leu Leu Ile Cys Lys Ser 
        515                 520                 525             


Arg Ser Leu Asp Arg Arg Gly Ile Gln Arg Ala Ala Asp Ile Glu Gln 
    530                 535                 540                 


Gln Ala Val Phe Ala Val Phe Asp Glu Asn Lys Ser Trp Tyr Leu Glu 
545                 550                 555                 560 


Asp Asn Ile Asn Lys Phe Cys Glu Asn Pro Asp Glu Val Lys Arg Asp 
                565                 570                 575     


Asp Pro Lys Phe Tyr Glu Ser Asn Ile Met Ser Asn Phe Thr Leu Ser 
            580                 585                 590         


Ala Ile Asn Gly Tyr Val Pro Glu Ser Ile Thr Thr Leu Gly Phe Cys 
        595                 600                 605             


Phe Asp Asp Thr Val Gln Trp His Phe Cys Ser Val Gly Thr Gln Asn 
    610                 615                 620                 


Glu Ile Leu Thr Ile His Phe Thr Gly His Ser Phe Ile Tyr Gly Lys 
625                 630                 635                 640 


Arg His Glu Asp Thr Leu Thr Leu Phe Pro Met Arg Gly Glu Ser Val 
                645                 650                 655     


Thr Val Thr Met Asp Asn Val Gly Thr Trp Met Leu Thr Ser Met Asn 
            660                 665                 670         


Ser Ser Pro Arg Ser Lys Lys Leu Arg Leu Lys Phe Arg Asp Val Lys 
        675                 680                 685             


Cys Ile Pro Asp Asp Asp Glu Asp Ser Tyr Glu Ile Phe Glu Pro Pro 
    690                 695                 700                 


Glu Ser Thr Val Met Ala Thr Arg Lys Met His Asp Arg Leu Glu Pro 
705                 710                 715                 720 


Glu Asp Glu Glu Ser Asp Ala Asp Tyr Asp Tyr Gln Asn Arg Leu Ala 
                725                 730                 735     


Ala Ala Leu Gly Ile Arg Ser Phe Arg Asn Ser Ser Leu Asn Gln Glu 
            740                 745                 750         


Glu Glu Glu Phe Asn Leu Thr Ala Leu Ala Leu Glu Asn Gly Thr Glu 
        755                 760                 765             


Phe Val Ser Ser Asn Thr Asp Ile Ile Val Gly Ser Asn Tyr Ser Ser 
    770                 775                 780                 


Pro Ser Asn Ile Ser Lys Phe Thr Val Asn Asn Leu Ala Glu Pro Gln 
785                 790                 795                 800 


Lys Ala Pro Ser His Gln Gln Ala Thr Thr Ala Gly Ser Pro Leu Arg 
                805                 810                 815     


His Leu Ile Gly Lys Asn Ser Val Leu Asn Ser Ser Thr Ala Glu His 
            820                 825                 830         


Ser Ser Pro Tyr Ser Glu Asp Pro Ile Glu Asp Pro Leu Gln Pro Asp 
        835                 840                 845             


Val Thr Gly Ile Arg Leu Leu Ser Leu Gly Ala Gly Glu Phe Lys Ser 
    850                 855                 860                 


Gln Glu His Ala Lys His Lys Gly Pro Lys Val Glu Arg Asp Gln Ala 
865                 870                 875                 880 


Ala Lys His Arg Phe Ser Trp Met Lys Leu Leu Ala His Lys Val Gly 
                885                 890                 895     


Arg His Leu Ser Gln Asp Thr Gly Ser Pro Ser Gly Met Arg Pro Trp 
            900                 905                 910         


Glu Asp Leu Pro Ser Gln Asp Thr Gly Ser Pro Ser Arg Met Arg Pro 
        915                 920                 925             


Trp Lys Asp Pro Pro Ser Asp Leu Leu Leu Leu Lys Gln Ser Asn Ser 
    930                 935                 940                 


Ser Lys Ile Leu Val Gly Arg Trp His Leu Ala Ser Glu Lys Gly Ser 
945                 950                 955                 960 


Tyr Glu Ile Ile Gln Asp Thr Asp Glu Asp Thr Ala Val Asn Asn Trp 
                965                 970                 975     


Leu Ile Ser Pro Gln Asn Ala Ser Arg Ala Trp Gly Glu Ser Thr Pro 
            980                 985                 990         


Leu Ala Asn Lys Pro Gly Lys Gln  Ser Gly His Pro Lys  Phe Pro Arg 
        995                 1000                 1005             


Val Arg  His Lys Ser Leu Gln  Val Arg Gln Asp Gly  Gly Lys Ser 
    1010                 1015                 1020             


Arg Leu  Lys Lys Ser Gln Phe  Leu Ile Lys Thr Arg  Lys Lys Lys 
    1025                 1030                 1035             


Lys Glu  Lys His Thr His His  Ala Pro Leu Ser Pro  Arg Thr Phe 
    1040                 1045                 1050             


His Pro  Leu Arg Ser Glu Ala  Tyr Asn Thr Phe Ser  Glu Arg Arg 
    1055                 1060                 1065             


Leu Lys  His Ser Leu Val Leu  His Lys Ser Asn Glu  Thr Ser Leu 
    1070                 1075                 1080             


Pro Thr  Asp Leu Asn Gln Thr  Leu Pro Ser Met Asp  Phe Gly Trp 
    1085                 1090                 1095             


Ile Ala  Ser Leu Pro Asp His  Asn Gln Asn Ser Ser  Asn Asp Thr 
    1100                 1105                 1110             


Gly Gln  Ala Ser Cys Pro Pro  Gly Leu Tyr Gln Thr  Val Pro Pro 
    1115                 1120                 1125             


Glu Glu  His Tyr Gln Thr Phe  Pro Ile Gln Asp Pro  Asp Gln Met 
    1130                 1135                 1140             


His Ser  Thr Ser Asp Pro Ser  His Arg Ser Ser Ser  Pro Glu Leu 
    1145                 1150                 1155             


Ser Glu  Met Leu Glu Tyr Asp  Arg Ser His Lys Ser  Phe Pro Thr 
    1160                 1165                 1170             


Asp Ile  Ser Gln Met Ser Pro  Ser Ser Glu His Glu  Val Trp Gln 
    1175                 1180                 1185             


Thr Val  Ile Ser Pro Asp Leu  Ser Gln Val Thr Leu  Ser Pro Glu 
    1190                 1195                 1200             


Leu Ser  Gln Thr Asn Leu Ser  Pro Asp Leu Ser His  Thr Thr Leu 
    1205                 1210                 1215             


Ser Pro  Glu Leu Ile Gln Arg  Asn Leu Ser Pro Ala  Leu Gly Gln 
    1220                 1225                 1230             


Met Pro  Ile Ser Pro Asp Leu  Ser His Thr Thr Leu  Ser Pro Asp 
    1235                 1240                 1245             


Leu Ser  His Thr Thr Leu Ser  Leu Asp Leu Ser Gln  Thr Asn Leu 
    1250                 1255                 1260             


Ser Pro  Glu Leu Ser Gln Thr  Asn Leu Ser Pro Ala  Leu Gly Gln 
    1265                 1270                 1275             


Met Pro  Leu Ser Pro Asp Leu  Ser His Thr Thr Leu  Ser Leu Asp 
    1280                 1285                 1290             


Phe Ser  Gln Thr Asn Leu Ser  Pro Glu Leu Ser His  Met Thr Leu 
    1295                 1300                 1305             


Ser Pro  Glu Leu Ser Gln Thr  Asn Leu Ser Pro Ala  Leu Gly Gln 
    1310                 1315                 1320             


Met Pro  Ile Ser Pro Asp Leu  Ser His Thr Thr Leu  Ser Leu Asp 
    1325                 1330                 1335             


Phe Ser  Gln Thr Asn Leu Ser  Pro Glu Leu Ser Gln  Thr Asn Leu 
    1340                 1345                 1350             


Ser Pro  Ala Leu Gly Gln Met  Pro Leu Ser Pro Asp  Pro Ser His 
    1355                 1360                 1365             


Thr Thr  Leu Ser Leu Asp Leu  Ser Gln Thr Asn Leu  Ser Pro Glu 
    1370                 1375                 1380             


Leu Ser  Gln Thr Asn Leu Ser  Pro Asp Leu Ser Glu  Met Pro Leu 
    1385                 1390                 1395             


Phe Ala  Asp Leu Ser Gln Ile  Pro Leu Thr Pro Asp  Leu Asp Gln 
    1400                 1405                 1410             


Met Thr  Leu Ser Pro Asp Leu  Gly Glu Thr Asp Leu  Ser Pro Asn 
    1415                 1420                 1425             


Phe Gly  Gln Met Ser Leu Ser  Pro Asp Leu Ser Gln  Val Thr Leu 
    1430                 1435                 1440             


Ser Pro  Asp Ile Ser Asp Thr  Thr Leu Leu Pro Asp  Leu Ser Gln 
    1445                 1450                 1455             


Ile Ser  Pro Pro Pro Asp Leu  Asp Gln Ile Phe Tyr  Pro Ser Glu 
    1460                 1465                 1470             


Ser Ser  Gln Ser Leu Leu Leu  Gln Glu Phe Asn Glu  Ser Phe Pro 
    1475                 1480                 1485             


Tyr Pro  Asp Leu Gly Gln Met  Pro Ser Pro Ser Ser  Pro Thr Leu 
    1490                 1495                 1500             


Asn Asp  Thr Phe Leu Ser Lys  Glu Phe Asn Pro Leu  Val Ile Val 
    1505                 1510                 1515             


Gly Leu  Ser Lys Asp Gly Thr  Asp Tyr Ile Glu Ile  Ile Pro Lys 
    1520                 1525                 1530             


Glu Glu  Val Gln Ser Ser Glu  Asp Asp Tyr Ala Glu  Ile Asp Tyr 
    1535                 1540                 1545             


Val Pro  Tyr Asp Asp Pro Tyr  Lys Thr Asp Val Arg  Thr Asn Ile 
    1550                 1555                 1560             


Asn Ser  Ser Arg Asp Pro Asp  Asn Ile Ala Ala Trp  Tyr Leu Arg 
    1565                 1570                 1575             


Ser Asn  Asn Gly Asn Arg Arg  Asn Tyr Tyr Ile Ala  Ala Glu Glu 
    1580                 1585                 1590             


Ile Ser  Trp Asp Tyr Ser Glu  Phe Val Gln Arg Glu  Thr Asp Ile 
    1595                 1600                 1605             


Glu Asp  Ser Asp Asp Ile Pro  Glu Asp Thr Thr Tyr  Lys Lys Val 
    1610                 1615                 1620             


Val Phe  Arg Lys Tyr Leu Asp  Ser Thr Phe Thr Lys  Arg Asp Pro 
    1625                 1630                 1635             


Arg Gly  Glu Tyr Glu Glu His  Leu Gly Ile Leu Gly  Pro Ile Ile 
    1640                 1645                 1650             


Arg Ala  Glu Val Asp Asp Val  Ile Gln Val Arg Phe  Lys Asn Leu 
    1655                 1660                 1665             


Ala Ser  Arg Pro Tyr Ser Leu  His Ala His Gly Leu  Ser Tyr Glu 
    1670                 1675                 1680             


Lys Ser  Ser Glu Gly Lys Thr  Tyr Glu Asp Asp Ser  Pro Glu Trp 
    1685                 1690                 1695             


Phe Lys  Glu Asp Asn Ala Val  Gln Pro Asn Ser Ser  Tyr Thr Tyr 
    1700                 1705                 1710             


Val Trp  His Ala Thr Glu Arg  Ser Gly Pro Glu Ser  Pro Gly Ser 
    1715                 1720                 1725             


Ala Cys  Arg Ala Trp Ala Tyr  Tyr Ser Ala Val Asn  Pro Glu Lys 
    1730                 1735                 1740             


Asp Ile  His Ser Gly Leu Ile  Gly Pro Leu Leu Ile  Cys Gln Lys 
    1745                 1750                 1755             


Gly Ile  Leu His Lys Asp Ser  Asn Met Pro Met Asp  Met Arg Glu 
    1760                 1765                 1770             


Phe Val  Leu Leu Phe Met Thr  Phe Asp Glu Lys Lys  Ser Trp Tyr 
    1775                 1780                 1785             


Tyr Glu  Lys Lys Ser Arg Ser  Ser Trp Arg Leu Thr  Ser Ser Glu 
    1790                 1795                 1800             


Met Lys  Lys Ser His Glu Phe  His Ala Ile Asn Gly  Met Ile Tyr 
    1805                 1810                 1815             


Ser Leu  Pro Gly Leu Lys Met  Tyr Glu Gln Glu Trp  Val Arg Leu 
    1820                 1825                 1830             


His Leu  Leu Asn Ile Gly Gly  Ser Gln Asp Ile His  Val Val His 
    1835                 1840                 1845             


Phe His  Gly Gln Thr Leu Leu  Glu Asn Gly Asn Lys  Gln His Gln 
    1850                 1855                 1860             


Leu Gly  Val Trp Pro Leu Leu  Pro Gly Ser Phe Lys  Thr Leu Glu 
    1865                 1870                 1875             


Met Lys  Ala Ser Lys Pro Gly  Trp Trp Leu Leu Asn  Thr Glu Val 
    1880                 1885                 1890             


Gly Glu  Asn Gln Arg Ala Gly  Met Gln Thr Pro Phe  Leu Ile Met 
    1895                 1900                 1905             


Asp Arg  Asp Cys Arg Met Pro  Met Gly Leu Ser Thr  Gly Ile Ile 
    1910                 1915                 1920             


Ser Asp  Ser Gln Ile Lys Ala  Ser Glu Phe Leu Gly  Tyr Trp Glu 
    1925                 1930                 1935             


Pro Arg  Leu Ala Arg Leu Asn  Asn Gly Gly Ser Tyr  Asn Ala Trp 
    1940                 1945                 1950             


Ser Val  Glu Lys Leu Ala Ala  Glu Phe Ala Ser Lys  Pro Trp Ile 
    1955                 1960                 1965             


Gln Val  Asp Met Gln Lys Glu  Val Ile Ile Thr Gly  Ile Gln Thr 
    1970                 1975                 1980             


Gln Gly  Ala Lys His Tyr Leu  Lys Ser Cys Tyr Thr  Thr Glu Phe 
    1985                 1990                 1995             


Tyr Val  Ala Tyr Ser Ser Asn  Gln Ile Asn Trp Gln  Ile Phe Lys 
    2000                 2005                 2010             


Gly Asn  Ser Thr Arg Asn Val  Met Tyr Phe Asn Gly  Asn Ser Asp 
    2015                 2020                 2025             


Ala Ser  Thr Ile Lys Glu Asn  Gln Phe Asp Pro Pro  Ile Val Ala 
    2030                 2035                 2040             


Arg Tyr  Ile Arg Ile Ser Pro  Thr Arg Ala Tyr Asn  Arg Pro Thr 
    2045                 2050                 2055             


Leu Arg  Leu Glu Leu Gln Gly  Cys Glu Val Asn Gly  Cys Ser Thr 
    2060                 2065                 2070             


Pro Leu  Gly Met Glu Asn Gly  Lys Ile Glu Asn Lys  Gln Ile Thr 
    2075                 2080                 2085             


Ala Ser  Ser Phe Lys Lys Ser  Trp Trp Gly Asp Tyr  Trp Glu Pro 
    2090                 2095                 2100             


Phe Arg  Ala Arg Leu Asn Ala  Gln Gly Arg Val Asn  Ala Trp Gln 
    2105                 2110                 2115             


Ala Lys  Ala Asn Asn Asn Lys  Gln Trp Leu Glu Ile  Asp Leu Leu 
    2120                 2125                 2130             


Lys Ile  Lys Lys Ile Thr Ala  Ile Ile Thr Gln Gly  Cys Lys Ser 
    2135                 2140                 2145             


Leu Ser  Ser Glu Met Tyr Val  Lys Ser Tyr Thr Ile  His Tyr Ser 
    2150                 2155                 2160             


Glu Gln  Gly Val Glu Trp Lys  Pro Tyr Arg Leu Lys  Ser Ser Met 
    2165                 2170                 2175             


Val Asp  Lys Ile Phe Glu Gly  Asn Thr Asn Thr Lys  Gly His Val 
    2180                 2185                 2190             


Lys Asn  Phe Phe Asn Pro Pro  Ile Ile Ser Arg Phe  Ile Arg Val 
    2195                 2200                 2205             


Ile Pro  Lys Thr Trp Asn Gln  Ser Ile Ala Leu Arg  Leu Glu Leu 
    2210                 2215                 2220             


Phe Gly  Cys Asp Ile Tyr 
    2225                 


<210>  4974
<211>  382
<212>  PRT
<213>  Homo Sapiens

<400>  4974

Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 
1               5                   10                  15      


Gly Cys Leu Ala Ala Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln 
            20                  25                  30          


Asn Gly Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys Phe Cys 
        35                  40                  45              


Leu Pro Ala Phe Glu Gly Arg Asn Cys Glu Thr His Lys Asp Asp Gln 
    50                  55                  60                  


Leu Ile Cys Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp 
65                  70                  75                  80  


His Thr Gly Thr Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu 
                85                  90                  95      


Leu Ala Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly 
            100                 105                 110         


Lys Ile Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg 
        115                 120                 125             


Ile Val Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val 
    130                 135                 140                 


Leu Leu Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn 
145                 150                 155                 160 


Thr Ile Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile Lys Asn 
                165                 170                 175     


Trp Arg Asn Leu Ile Ala Val Leu Gly Glu His Asp Leu Ser Glu His 
            180                 185                 190         


Asp Gly Asp Glu Gln Ser Arg Arg Val Ala Gln Val Ile Ile Pro Ser 
        195                 200                 205             


Thr Tyr Val Pro Gly Thr Thr Asn His Asp Ile Ala Leu Leu Arg Leu 
    210                 215                 220                 


His Gln Pro Val Val Leu Thr Asp His Val Val Pro Leu Cys Leu Pro 
225                 230                 235                 240 


Glu Arg Thr Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu 
                245                 250                 255     


Val Ser Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu 
            260                 265                 270         


Leu Met Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu Gln 
        275                 280                 285             


Gln Ser Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu Tyr Met Phe 
    290                 295                 300                 


Cys Ala Gly Tyr Ser Asp Gly Ser Lys Asp Ser Cys Lys Gly Asp Ser 
305                 310                 315                 320 


Gly Gly Pro His Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly 
                325                 330                 335     


Ile Val Ser Trp Gly Gln Gly Cys Ala Thr Val Gly His Phe Gly Val 
            340                 345                 350         


Tyr Thr Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg 
        355                 360                 365             


Ser Glu Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro 
    370                 375                 380         


<210>  4975
<211>  74
<212>  PRT
<213>  Homo Sapiens

<400>  4975

Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 
1               5                   10                  15      


Gly Cys Leu Ala Ala Gly Gly Ser Pro Arg Arg Pro Ala Pro Ala Pro 
            20                  25                  30          


Ala Arg Gln Arg Val Pro Gly Gly Ala Ala Ala Gly Leu Pro Gly Glu 
        35                  40                  45              


Gly Val Gln Gly Gly Ala Val Leu Leu Arg Gly Gly Pro Gly Asp Leu 
    50                  55                  60                  


Gln Gly Arg Gly Glu Asp Val Val Ser Gly 
65                  70                  


<210>  4976
<211>  466
<212>  PRT
<213>  Homo Sapiens

<400>  4976

Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 
1               5                   10                  15      


Gly Cys Leu Ala Ala Gly Gly Val Ala Lys Ala Ser Gly Gly Glu Thr 
            20                  25                  30          


Arg Asp Met Pro Trp Lys Pro Gly Pro His Arg Val Phe Val Thr Gln 
        35                  40                  45              


Glu Glu Ala His Gly Val Leu His Arg Arg Arg Arg Ala Asn Ala Phe 
    50                  55                  60                  


Leu Glu Glu Leu Arg Pro Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu 
65                  70                  75                  80  


Gln Cys Ser Phe Glu Glu Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg 
                85                  90                  95      


Thr Lys Leu Phe Trp Ile Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser 
            100                 105                 110         


Ser Pro Cys Gln Asn Gly Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr 
        115                 120                 125             


Ile Cys Phe Cys Leu Pro Ala Phe Glu Gly Arg Asn Cys Glu Thr His 
    130                 135                 140                 


Lys Asp Asp Gln Leu Ile Cys Val Asn Glu Asn Gly Gly Cys Glu Gln 
145                 150                 155                 160 


Tyr Cys Ser Asp His Thr Gly Thr Lys Arg Ser Cys Arg Cys His Glu 
                165                 170                 175     


Gly Tyr Ser Leu Leu Ala Asp Gly Val Ser Cys Thr Pro Thr Val Glu 
            180                 185                 190         


Tyr Pro Cys Gly Lys Ile Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys 
        195                 200                 205             


Pro Gln Gly Arg Ile Val Gly Gly Lys Val Cys Pro Lys Gly Glu Cys 
    210                 215                 220                 


Pro Trp Gln Val Leu Leu Leu Val Asn Gly Ala Gln Leu Cys Gly Gly 
225                 230                 235                 240 


Thr Leu Ile Asn Thr Ile Trp Val Val Ser Ala Ala His Cys Phe Asp 
                245                 250                 255     


Lys Ile Lys Asn Trp Arg Asn Leu Ile Ala Val Leu Gly Glu His Asp 
            260                 265                 270         


Leu Ser Glu His Asp Gly Asp Glu Gln Ser Arg Arg Val Ala Gln Val 
        275                 280                 285             


Ile Ile Pro Ser Thr Tyr Val Pro Gly Thr Thr Asn His Asp Ile Ala 
    290                 295                 300                 


Leu Leu Arg Leu His Gln Pro Val Val Leu Thr Asp His Val Val Pro 
305                 310                 315                 320 


Leu Cys Leu Pro Glu Arg Thr Phe Ser Glu Arg Thr Leu Ala Phe Val 
                325                 330                 335     


Arg Phe Ser Leu Val Ser Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala 
            340                 345                 350         


Thr Ala Leu Glu Leu Met Val Leu Asn Val Pro Arg Leu Met Thr Gln 
        355                 360                 365             


Asp Cys Leu Gln Gln Ser Arg Lys Val Gly Asp Ser Pro Asn Ile Thr 
    370                 375                 380                 


Glu Tyr Met Phe Cys Ala Gly Tyr Ser Asp Gly Ser Lys Asp Ser Cys 
385                 390                 395                 400 


Lys Gly Asp Ser Gly Gly Pro His Ala Thr His Tyr Arg Gly Thr Trp 
                405                 410                 415     


Tyr Leu Thr Gly Ile Val Ser Trp Gly Gln Gly Cys Ala Thr Val Gly 
            420                 425                 430         


His Phe Gly Val Tyr Thr Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln 
        435                 440                 445             


Lys Leu Met Arg Ser Glu Pro Arg Pro Gly Val Leu Leu Arg Ala Pro 
    450                 455                 460                 


Phe Pro 
465     


<210>  4977
<211>  444
<212>  PRT
<213>  Homo Sapiens

<400>  4977

Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 
1               5                   10                  15      


Gly Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly Val 
            20                  25                  30          


Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 
        35                  40                  45              


Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 
    50                  55                  60                  


Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 
65                  70                  75                  80  


Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly 
                85                  90                  95      


Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro 
            100                 105                 110         


Ala Phe Glu Gly Arg Asn Cys Glu Thr His Lys Asp Asp Gln Leu Ile 
        115                 120                 125             


Cys Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 
    130                 135                 140                 


Gly Thr Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 
145                 150                 155                 160 


Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 
                165                 170                 175     


Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val 
            180                 185                 190         


Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu 
        195                 200                 205             


Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile 
    210                 215                 220                 


Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile Lys Asn Trp Arg 
225                 230                 235                 240 


Asn Leu Ile Ala Val Leu Gly Glu His Asp Leu Ser Glu His Asp Gly 
                245                 250                 255     


Asp Glu Gln Ser Arg Arg Val Ala Gln Val Ile Ile Pro Ser Thr Tyr 
            260                 265                 270         


Val Pro Gly Thr Thr Asn His Asp Ile Ala Leu Leu Arg Leu His Gln 
        275                 280                 285             


Pro Val Val Leu Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg 
    290                 295                 300                 


Thr Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu Val Ser 
305                 310                 315                 320 


Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu Met 
                325                 330                 335     


Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu Gln Gln Ser 
            340                 345                 350         


Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala 
        355                 360                 365             


Gly Tyr Ser Asp Gly Ser Lys Asp Ser Cys Lys Gly Asp Ser Gly Gly 
    370                 375                 380                 


Pro His Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val 
385                 390                 395                 400 


Ser Trp Gly Gln Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr 
                405                 410                 415     


Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg Ser Glu 
            420                 425                 430         


Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro 
        435                 440                 


<210>  4978
<211>  165
<212>  PRT
<213>  Homo Sapiens

<400>  4978

Met His Arg Asp Ala Arg Ala Gln Lys Ala Ser Arg Gly Ala Thr Arg 
1               5                   10                  15      


Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr Met Gln Ser 
            20                  25                  30          


Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro Arg Val Pro 
        35                  40                  45              


Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys Thr Leu Phe 
    50                  55                  60                  


Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro Arg Pro Pro 
65                  70                  75                  80  


Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val Tyr Asp Thr 
                85                  90                  95      


Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val Ser Leu His 
            100                 105                 110         


Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala Glu Tyr Asp 
        115                 120                 125             


Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val Phe Pro Gly 
    130                 135                 140                 


Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn Gly Pro Met 
145                 150                 155                 160 


Ala Ser Asp Pro Leu 
                165 


<210>  4979
<211>  222
<212>  PRT
<213>  Homo Sapiens

<400>  4979

Met His Arg Asp Ala Arg Ala Gln Lys Ala Ser Arg Gly Phe Pro Pro 
1               5                   10                  15      


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
            20                  25                  30          


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
        35                  40                  45              


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
    50                  55                  60                  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
65                  70                  75                  80  


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
                85                  90                  95      


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
            100                 105                 110         


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
        115                 120                 125             


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
    130                 135                 140                 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
145                 150                 155                 160 


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
                165                 170                 175     


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
            180                 185                 190         


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
        195                 200                 205             


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val 
    210                 215                 220         


<210>  4980
<211>  262
<212>  PRT
<213>  Homo Sapiens

<400>  4980

Met Leu Glu Gln Glu Glu Glu Arg Glu Asn Ala Arg Lys Gly Gly Ser 
1               5                   10                  15      


Ala Ala His Phe Gln Thr Ile Ile Arg Ser Cys Glu Arg Ser Ile Arg 
            20                  25                  30          


Arg Ile Ala Arg Gly Lys Ser Ala Pro Met Ile Gln Ser Pro Pro Thr 
        35                  40                  45              


Arg Pro Phe Leu Gln Gln Val Phe Phe Gly Asn Val Asp Ser Ser Gly 
    50                  55                  60                  


Ile Lys His Asn Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr Ile Arg 
65                  70                  75                  80  


Leu His Pro Thr His Tyr Ser Ile Arg Ser Thr Leu Arg Met Glu Leu 
                85                  90                  95      


Met Gly Cys Asp Leu Asn Ser Cys Ser Met Pro Leu Gly Met Glu Ser 
            100                 105                 110         


Lys Ala Ile Ser Asp Ala Gln Ile Thr Ala Ser Ser Tyr Phe Thr Asn 
        115                 120                 125             


Met Phe Ala Thr Trp Ser Pro Ser Lys Ala Arg Leu His Leu Gln Gly 
    130                 135                 140                 


Arg Ser Asn Ala Trp Arg Pro Gln Val Asn Asn Pro Lys Glu Trp Leu 
145                 150                 155                 160 


Gln Val Asp Phe Gln Lys Thr Met Lys Val Thr Gly Val Thr Thr Gln 
                165                 170                 175     


Gly Val Lys Ser Leu Leu Thr Ser Met Tyr Val Lys Glu Phe Leu Ile 
            180                 185                 190         


Ser Ser Ser Gln Asp Gly His Gln Trp Thr Leu Phe Phe Gln Asn Gly 
        195                 200                 205             


Lys Val Lys Val Phe Gln Gly Asn Gln Asp Ser Phe Thr Pro Val Val 
    210                 215                 220                 


Asn Ser Leu Asp Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile His Pro 
225                 230                 235                 240 


Gln Ser Trp Val His Gln Ile Ala Leu Arg Met Glu Val Leu Gly Cys 
                245                 250                 255     


Glu Ala Gln Asp Leu Tyr 
            260         


<210>  4981
<211>  63
<212>  PRT
<213>  Homo Sapiens

<400>  4981

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      


Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Asp Phe Leu Leu Glu Cys Gln Asn 
        35                  40                  45              


Leu Phe His Ser Thr Pro Gln Ser Cys Thr Lys Arg Leu Cys Leu 
    50                  55                  60              


<210>  4982
<211>  2351
<212>  PRT
<213>  Homo Sapiens

<400>  4982

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      


Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              


Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  


Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  


Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      


Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         


His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             


Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 


Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 


Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     


Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         


Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             


Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 


Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 


Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     


Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         


Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             


Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 


Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 


Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     


Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         


Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             


Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 


Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 


Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     


Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         


Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             


Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 


Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 


Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     


His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         


Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             


Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 


Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     


Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         


Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             


Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 


Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 


Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     


Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         


Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             


Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 


Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         


Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro 
        755                 760                 765             


Ser Thr Arg Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp 
    770                 775                 780                 


Ile Glu Lys Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys 
785                 790                 795                 800 


Ile Gln Asn Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser 
                805                 810                 815     


Pro Thr Pro His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr 
            820                 825                 830         


Glu Thr Phe Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn 
        835                 840                 845             


Ser Leu Ser Glu Met Thr His Phe Arg Pro Gln Leu His His Ser Gly 
    850                 855                 860                 


Asp Met Val Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu 
865                 870                 875                 880 


Lys Leu Gly Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys 
                885                 890                 895     


Val Ser Ser Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn 
            900                 905                 910         


Leu Ala Ala Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met 
        915                 920                 925             


Pro Val His Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys 
    930                 935                 940                 


Ser Ser Pro Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu 
945                 950                 955                 960 


Asn Asn Asp Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu 
                965                 970                 975     


Ser Ser Trp Gly Lys Asn Val Ser Ser Thr Glu Ser Gly Arg Leu Phe 
            980                 985                 990         


Lys Gly Lys Arg Ala His Gly Pro  Ala Leu Leu Thr Lys  Asp Asn Ala 
        995                 1000                 1005             


Leu Phe  Lys Val Ser Ile Ser  Leu Leu Lys Thr Asn  Lys Thr Ser 
    1010                 1015                 1020             


Asn Asn  Ser Ala Thr Asn Arg  Lys Thr His Ile Asp  Gly Pro Ser 
    1025                 1030                 1035             


Leu Leu  Ile Glu Asn Ser Pro  Ser Val Trp Gln Asn  Ile Leu Glu 
    1040                 1045                 1050             


Ser Asp  Thr Glu Phe Lys Lys  Val Thr Pro Leu Ile  His Asp Arg 
    1055                 1060                 1065             


Met Leu  Met Asp Lys Asn Ala  Thr Ala Leu Arg Leu  Asn His Met 
    1070                 1075                 1080             


Ser Asn  Lys Thr Thr Ser Ser  Lys Asn Met Glu Met  Val Gln Gln 
    1085                 1090                 1095             


Lys Lys  Glu Gly Pro Ile Pro  Pro Asp Ala Gln Asn  Pro Asp Met 
    1100                 1105                 1110             


Ser Phe  Phe Lys Met Leu Phe  Leu Pro Glu Ser Ala  Arg Trp Ile 
    1115                 1120                 1125             


Gln Arg  Thr His Gly Lys Asn  Ser Leu Asn Ser Gly  Gln Gly Pro 
    1130                 1135                 1140             


Ser Pro  Lys Gln Leu Val Ser  Leu Gly Pro Glu Lys  Ser Val Glu 
    1145                 1150                 1155             


Gly Gln  Asn Phe Leu Ser Glu  Lys Asn Lys Val Val  Val Gly Lys 
    1160                 1165                 1170             


Gly Glu  Phe Thr Lys Asp Val  Gly Leu Lys Glu Met  Val Phe Pro 
    1175                 1180                 1185             


Ser Ser  Arg Asn Leu Phe Leu  Thr Asn Leu Asp Asn  Leu His Glu 
    1190                 1195                 1200             


Asn Asn  Thr His Asn Gln Glu  Lys Lys Ile Gln Glu  Glu Ile Glu 
    1205                 1210                 1215             


Lys Lys  Glu Thr Leu Ile Gln  Glu Asn Val Val Leu  Pro Gln Ile 
    1220                 1225                 1230             


His Thr  Val Thr Gly Thr Lys  Asn Phe Met Lys Asn  Leu Phe Leu 
    1235                 1240                 1245             


Leu Ser  Thr Arg Gln Asn Val  Glu Gly Ser Tyr Asp  Gly Ala Tyr 
    1250                 1255                 1260             


Ala Pro  Val Leu Gln Asp Phe  Arg Ser Leu Asn Asp  Ser Thr Asn 
    1265                 1270                 1275             


Arg Thr  Lys Lys His Thr Ala  His Phe Ser Lys Lys  Gly Glu Glu 
    1280                 1285                 1290             


Glu Asn  Leu Glu Gly Leu Gly  Asn Gln Thr Lys Gln  Ile Val Glu 
    1295                 1300                 1305             


Lys Tyr  Ala Cys Thr Thr Arg  Ile Ser Pro Asn Thr  Ser Gln Gln 
    1310                 1315                 1320             


Asn Phe  Val Thr Gln Arg Ser  Lys Arg Ala Leu Lys  Gln Phe Arg 
    1325                 1330                 1335             


Leu Pro  Leu Glu Glu Thr Glu  Leu Glu Lys Arg Ile  Ile Val Asp 
    1340                 1345                 1350             


Asp Thr  Ser Thr Gln Trp Ser  Lys Asn Met Lys His  Leu Thr Pro 
    1355                 1360                 1365             


Ser Thr  Leu Thr Gln Ile Asp  Tyr Asn Glu Lys Glu  Lys Gly Ala 
    1370                 1375                 1380             


Ile Thr  Gln Ser Pro Leu Ser  Asp Cys Leu Thr Arg  Ser His Ser 
    1385                 1390                 1395             


Ile Pro  Gln Ala Asn Arg Ser  Pro Leu Pro Ile Ala  Lys Val Ser 
    1400                 1405                 1410             


Ser Phe  Pro Ser Ile Arg Pro  Ile Tyr Leu Thr Arg  Val Leu Phe 
    1415                 1420                 1425             


Gln Asp  Asn Ser Ser His Leu  Pro Ala Ala Ser Tyr  Arg Lys Lys 
    1430                 1435                 1440             


Asp Ser  Gly Val Gln Glu Ser  Ser His Phe Leu Gln  Gly Ala Lys 
    1445                 1450                 1455             


Lys Asn  Asn Leu Ser Leu Ala  Ile Leu Thr Leu Glu  Met Thr Gly 
    1460                 1465                 1470             


Asp Gln  Arg Glu Val Gly Ser  Leu Gly Thr Ser Ala  Thr Asn Ser 
    1475                 1480                 1485             


Val Thr  Tyr Lys Lys Val Glu  Asn Thr Val Leu Pro  Lys Pro Asp 
    1490                 1495                 1500             


Leu Pro  Lys Thr Ser Gly Lys  Val Glu Leu Leu Pro  Lys Val His 
    1505                 1510                 1515             


Ile Tyr  Gln Lys Asp Leu Phe  Pro Thr Glu Thr Ser  Asn Gly Ser 
    1520                 1525                 1530             


Pro Gly  His Leu Asp Leu Val  Glu Gly Ser Leu Leu  Gln Gly Thr 
    1535                 1540                 1545             


Glu Gly  Ala Ile Lys Trp Asn  Glu Ala Asn Arg Pro  Gly Lys Val 
    1550                 1555                 1560             


Pro Phe  Leu Arg Val Ala Thr  Glu Ser Ser Ala Lys  Thr Pro Ser 
    1565                 1570                 1575             


Lys Leu  Leu Asp Pro Leu Ala  Trp Asp Asn His Tyr  Gly Thr Gln 
    1580                 1585                 1590             


Ile Pro  Lys Glu Glu Trp Lys  Ser Gln Glu Lys Ser  Pro Glu Lys 
    1595                 1600                 1605             


Thr Ala  Phe Lys Lys Lys Asp  Thr Ile Leu Ser Leu  Asn Ala Cys 
    1610                 1615                 1620             


Glu Ser  Asn His Ala Ile Ala  Ala Ile Asn Glu Gly  Gln Asn Lys 
    1625                 1630                 1635             


Pro Glu  Ile Glu Val Thr Trp  Ala Lys Gln Gly Arg  Thr Glu Arg 
    1640                 1645                 1650             


Leu Cys  Ser Gln Asn Pro Pro  Val Leu Lys Arg His  Gln Arg Glu 
    1655                 1660                 1665             


Ile Thr  Arg Thr Thr Leu Gln  Ser Asp Gln Glu Glu  Ile Asp Tyr 
    1670                 1675                 1680             


Asp Asp  Thr Ile Ser Val Glu  Met Lys Lys Glu Asp  Phe Asp Ile 
    1685                 1690                 1695             


Tyr Asp  Glu Asp Glu Asn Gln  Ser Pro Arg Ser Phe  Gln Lys Lys 
    1700                 1705                 1710             


Thr Arg  His Tyr Phe Ile Ala  Ala Val Glu Arg Leu  Trp Asp Tyr 
    1715                 1720                 1725             


Gly Met  Ser Ser Ser Pro His  Val Leu Arg Asn Arg  Ala Gln Ser 
    1730                 1735                 1740             


Gly Ser  Val Pro Gln Phe Lys  Lys Val Val Phe Gln  Glu Phe Thr 
    1745                 1750                 1755             


Asp Gly  Ser Phe Thr Gln Pro  Leu Tyr Arg Gly Glu  Leu Asn Glu 
    1760                 1765                 1770             


His Leu  Gly Leu Leu Gly Pro  Tyr Ile Arg Ala Glu  Val Glu Asp 
    1775                 1780                 1785             


Asn Ile  Met Val Thr Phe Arg  Asn Gln Ala Ser Arg  Pro Tyr Ser 
    1790                 1795                 1800             


Phe Tyr  Ser Ser Leu Ile Ser  Tyr Glu Glu Asp Gln  Arg Gln Gly 
    1805                 1810                 1815             


Ala Glu  Pro Arg Lys Asn Phe  Val Lys Pro Asn Glu  Thr Lys Thr 
    1820                 1825                 1830             


Tyr Phe  Trp Lys Val Gln His  His Met Ala Pro Thr  Lys Asp Glu 
    1835                 1840                 1845             


Phe Asp  Cys Lys Ala Trp Ala  Tyr Phe Ser Asp Val  Asp Leu Glu 
    1850                 1855                 1860             


Lys Asp  Val His Ser Gly Leu  Ile Gly Pro Leu Leu  Val Cys His 
    1865                 1870                 1875             


Thr Asn  Thr Leu Asn Pro Ala  His Gly Arg Gln Val  Thr Val Gln 
    1880                 1885                 1890             


Glu Phe  Ala Leu Phe Phe Thr  Ile Phe Asp Glu Thr  Lys Ser Trp 
    1895                 1900                 1905             


Tyr Phe  Thr Glu Asn Met Glu  Arg Asn Cys Arg Ala  Pro Cys Asn 
    1910                 1915                 1920             


Ile Gln  Met Glu Asp Pro Thr  Phe Lys Glu Asn Tyr  Arg Phe His 
    1925                 1930                 1935             


Ala Ile  Asn Gly Tyr Ile Met  Asp Thr Leu Pro Gly  Leu Val Met 
    1940                 1945                 1950             


Ala Gln  Asp Gln Arg Ile Arg  Trp Tyr Leu Leu Ser  Met Gly Ser 
    1955                 1960                 1965             


Asn Glu  Asn Ile His Ser Ile  His Phe Ser Gly His  Val Phe Thr 
    1970                 1975                 1980             


Val Arg  Lys Lys Glu Glu Tyr  Lys Met Ala Leu Tyr  Asn Leu Tyr 
    1985                 1990                 1995             


Pro Gly  Val Phe Glu Thr Val  Glu Met Leu Pro Ser  Lys Ala Gly 
    2000                 2005                 2010             


Ile Trp  Arg Val Glu Cys Leu  Ile Gly Glu His Leu  His Ala Gly 
    2015                 2020                 2025             


Met Ser  Thr Leu Phe Leu Val  Tyr Ser Asn Lys Cys  Gln Thr Pro 
    2030                 2035                 2040             


Leu Gly  Met Ala Ser Gly His  Ile Arg Asp Phe Gln  Ile Thr Ala 
    2045                 2050                 2055             


Ser Gly  Gln Tyr Gly Gln Trp  Ala Pro Lys Leu Ala  Arg Leu His 
    2060                 2065                 2070             


Tyr Ser  Gly Ser Ile Asn Ala  Trp Ser Thr Lys Glu  Pro Phe Ser 
    2075                 2080                 2085             


Trp Ile  Lys Val Asp Leu Leu  Ala Pro Met Ile Ile  His Gly Ile 
    2090                 2095                 2100             


Lys Thr  Gln Gly Ala Arg Gln  Lys Phe Ser Ser Leu  Tyr Ile Ser 
    2105                 2110                 2115             


Gln Phe  Ile Ile Met Tyr Ser  Leu Asp Gly Lys Lys  Trp Gln Thr 
    2120                 2125                 2130             


Tyr Arg  Gly Asn Ser Thr Gly  Thr Leu Met Val Phe  Phe Gly Asn 
    2135                 2140                 2145             


Val Asp  Ser Ser Gly Ile Lys  His Asn Ile Phe Asn  Pro Pro Ile 
    2150                 2155                 2160             


Ile Ala  Arg Tyr Ile Arg Leu  His Pro Thr His Tyr  Ser Ile Arg 
    2165                 2170                 2175             


Ser Thr  Leu Arg Met Glu Leu  Met Gly Cys Asp Leu  Asn Ser Cys 
    2180                 2185                 2190             


Ser Met  Pro Leu Gly Met Glu  Ser Lys Ala Ile Ser  Asp Ala Gln 
    2195                 2200                 2205             


Ile Thr  Ala Ser Ser Tyr Phe  Thr Asn Met Phe Ala  Thr Trp Ser 
    2210                 2215                 2220             


Pro Ser  Lys Ala Arg Leu His  Leu Gln Gly Arg Ser  Asn Ala Trp 
    2225                 2230                 2235             


Arg Pro  Gln Val Asn Asn Pro  Lys Glu Trp Leu Gln  Val Asp Phe 
    2240                 2245                 2250             


Gln Lys  Thr Met Lys Val Thr  Gly Val Thr Thr Gln  Gly Val Lys 
    2255                 2260                 2265             


Ser Leu  Leu Thr Ser Met Tyr  Val Lys Glu Phe Leu  Ile Ser Ser 
    2270                 2275                 2280             


Ser Gln  Asp Gly His Gln Trp  Thr Leu Phe Phe Gln  Asn Gly Lys 
    2285                 2290                 2295             


Val Lys  Val Phe Gln Gly Asn  Gln Asp Ser Phe Thr  Pro Val Val 
    2300                 2305                 2310             


Asn Ser  Leu Asp Pro Pro Leu  Leu Thr Arg Tyr Leu  Arg Ile His 
    2315                 2320                 2325             


Pro Gln  Ser Trp Val His Gln  Ile Ala Leu Arg Met  Glu Val Leu 
    2330                 2335                 2340             


Gly Cys  Glu Ala Gln Asp Leu  Tyr 
    2345                 2350     


<210>  4983
<211>  216
<212>  PRT
<213>  Homo Sapiens

<400>  4983

Met Arg Ile Gln Asp Pro Gly Lys Val Phe Phe Gly Asn Val Asp Ser 
1               5                   10                  15      


Ser Gly Ile Lys His Asn Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr 
            20                  25                  30          


Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg Ser Thr Leu Arg Met 
        35                  40                  45              


Glu Leu Met Gly Cys Asp Leu Asn Ser Cys Ser Met Pro Leu Gly Met 
    50                  55                  60                  


Glu Ser Lys Ala Ile Ser Asp Ala Gln Ile Thr Ala Ser Ser Tyr Phe 
65                  70                  75                  80  


Thr Asn Met Phe Ala Thr Trp Ser Pro Ser Lys Ala Arg Leu His Leu 
                85                  90                  95      


Gln Gly Arg Ser Asn Ala Trp Arg Pro Gln Val Asn Asn Pro Lys Glu 
            100                 105                 110         


Trp Leu Gln Val Asp Phe Gln Lys Thr Met Lys Val Thr Gly Val Thr 
        115                 120                 125             


Thr Gln Gly Val Lys Ser Leu Leu Thr Ser Met Tyr Val Lys Glu Phe 
    130                 135                 140                 


Leu Ile Ser Ser Ser Gln Asp Gly His Gln Trp Thr Leu Phe Phe Gln 
145                 150                 155                 160 


Asn Gly Lys Val Lys Val Phe Gln Gly Asn Gln Asp Ser Phe Thr Pro 
                165                 170                 175     


Val Val Asn Ser Leu Asp Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile 
            180                 185                 190         


His Pro Gln Ser Trp Val His Gln Ile Ala Leu Arg Met Glu Val Leu 
        195                 200                 205             


Gly Cys Glu Ala Gln Asp Leu Tyr 
    210                 215     


<210>  4984
<211>  461
<212>  PRT
<213>  Homo Sapiens

<400>  4984

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
    450                 455                 460     


<210>  4985
<211>  423
<212>  PRT
<213>  Homo Sapiens

<400>  4985

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Val Thr Cys 
                85                  90                  95      


Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe Cys Lys Asn Ser Ala Asp 
            100                 105                 110         


Asn Lys Val Val Cys Ser Cys Thr Glu Gly Tyr Arg Leu Ala Glu Asn 
        115                 120                 125             


Gln Lys Ser Cys Glu Pro Ala Val Pro Phe Pro Cys Gly Arg Val Ser 
    130                 135                 140                 


Val Ser Gln Thr Ser Lys Leu Thr Arg Ala Glu Thr Val Phe Pro Asp 
145                 150                 155                 160 


Val Asp Tyr Val Asn Ser Thr Glu Ala Glu Thr Ile Leu Asp Asn Ile 
                165                 170                 175     


Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe Thr Arg Val Val Gly Gly 
            180                 185                 190         


Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp Gln Val Val Leu Asn Gly 
        195                 200                 205             


Lys Val Asp Ala Phe Cys Gly Gly Ser Ile Val Asn Glu Lys Trp Ile 
    210                 215                 220                 


Val Thr Ala Ala His Cys Val Glu Thr Gly Val Lys Ile Thr Val Val 
225                 230                 235                 240 


Ala Gly Glu His Asn Ile Glu Glu Thr Glu His Thr Glu Gln Lys Arg 
                245                 250                 255     


Asn Val Ile Arg Ile Ile Pro His His Asn Tyr Asn Ala Ala Ile Asn 
            260                 265                 270         


Lys Tyr Asn His Asp Ile Ala Leu Leu Glu Leu Asp Glu Pro Leu Val 
        275                 280                 285             


Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile Ala Asp Lys Glu Tyr Thr 
    290                 295                 300                 


Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr Val Ser Gly Trp Gly Arg 
305                 310                 315                 320 


Val Phe His Lys Gly Arg Ser Ala Leu Val Leu Gln Tyr Leu Arg Val 
                325                 330                 335     


Pro Leu Val Asp Arg Ala Thr Cys Leu Arg Ser Thr Lys Phe Thr Ile 
            340                 345                 350         


Tyr Asn Asn Met Phe Cys Ala Gly Phe His Glu Gly Gly Arg Asp Ser 
        355                 360                 365             


Cys Gln Gly Asp Ser Gly Gly Pro His Val Thr Glu Val Glu Gly Thr 
    370                 375                 380                 


Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly Glu Glu Cys Ala Met Lys 
385                 390                 395                 400 


Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser Arg Tyr Val Asn Trp Ile 
                405                 410                 415     


Lys Glu Lys Thr Lys Leu Thr 
            420             


<210>  4986
<211>  38
<212>  PRT
<213>  Homo Sapiens

<400>  4986

Leu Thr Gln Val Leu Arg Ala Val Leu Ser Ala Cys Thr Trp Val Ser 
1               5                   10                  15      


Arg Lys Gly Asp Leu Gln Arg Met Lys Gln Thr His Lys Gly Lys Arg 
            20                  25                  30          


Thr Phe Ser Gln Asp Gly 
        35              


<210>  4987
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  4987

Met Ala Phe Thr Gly Lys Phe Glu Met Glu Ser Glu Lys Asn Tyr Asp 
1               5                   10                  15      


Glu Phe Met Lys Leu Leu Gly Ile Ser Ser Asp Val Ile Glu Lys Ala 
            20                  25                  30          


Arg Asn Phe Lys Ile Val Thr Glu Val Gln Gln Asp Gly Gln Asp Phe 
        35                  40                  45              


Thr Trp Ser Gln His Tyr Ser Gly Gly His Thr Met Thr Asn Lys Phe 
    50                  55                  60                  


Thr Val Gly Lys Glu Ser Asn Ile Gln Thr Met Gly Gly Lys Thr Phe 
65                  70                  75                  80  


Lys Ala Thr Val Gln Met Glu Gly Gly Lys Leu Val Val Asn Phe Pro 
                85                  90                  95      


Asn Tyr His Gln Thr Ser Glu Ile Val Gly Asp Lys Leu Val Glu Val 
            100                 105                 110         


Ser Thr Ile Gly Gly Val Thr Tyr Glu Arg Val Ser Lys Arg Leu Ala 
        115                 120                 125             


<210>  4988
<211>  177
<212>  PRT
<213>  Homo Sapiens

<400>  4988

Met Lys Thr Val Thr Met Met Met Val Val Glu Met Gln Ala Leu Thr 
1               5                   10                  15      


Gln Val Leu Arg Ala Val Leu Ser Ala Cys Thr Trp Val Ser Arg Lys 
            20                  25                  30          


Gly Asp Leu Gln Arg Met Lys Gln Thr His Lys Gly Lys Pro Pro Ser 
        35                  40                  45              


Ser Met Ala Phe Thr Gly Lys Phe Glu Met Glu Ser Glu Lys Asn Tyr 
    50                  55                  60                  


Asp Glu Phe Met Lys Leu Leu Gly Ile Ser Ser Asp Val Ile Glu Lys 
65                  70                  75                  80  


Ala Arg Asn Phe Lys Ile Val Thr Glu Val Gln Gln Asp Gly Gln Asp 
                85                  90                  95      


Phe Thr Trp Ser Gln His Tyr Ser Gly Gly His Thr Met Thr Asn Lys 
            100                 105                 110         


Phe Thr Val Gly Lys Glu Ser Asn Ile Gln Thr Met Gly Gly Lys Thr 
        115                 120                 125             


Phe Lys Ala Thr Val Gln Met Glu Gly Gly Lys Leu Val Val Asn Phe 
    130                 135                 140                 


Pro Asn Tyr His Gln Thr Ser Glu Ile Val Gly Asp Lys Leu Val Glu 
145                 150                 155                 160 


Val Ser Thr Ile Gly Gly Val Thr Tyr Glu Arg Val Ser Lys Arg Leu 
                165                 170                 175     


Ala 
    


<210>  4989
<211>  67
<212>  PRT
<213>  Homo Sapiens

<400>  4989

Met Ala Glu Pro Asp Tyr Ile Glu Asp Asp Asn Pro Glu Leu Ile Arg 
1               5                   10                  15      


Pro Gln Lys Leu Ile Asn Pro Val Lys Thr Ser Arg Asn His Gln Asp 
            20                  25                  30          


Leu His Arg Glu Leu Leu Met Asn Gln Lys Arg Gly Leu Ala Pro Gln 
        35                  40                  45              


Asn Lys Pro Glu Leu Gln Lys Val Met Glu Lys Arg Lys Arg Asp Gln 
    50                  55                  60                  


Val Ile Lys 
65          


<210>  4990
<211>  84
<212>  PRT
<213>  Homo Sapiens

<400>  4990

Met Ala Glu Pro Asp Tyr Ile Glu Asp Asp Asn Pro Glu Leu Ile Arg 
1               5                   10                  15      


Pro Gln Lys Leu Ile Asn Pro Val Lys Thr Ser Arg Asn His Gln Asp 
            20                  25                  30          


Leu His Arg Glu Leu Leu Met Asn Gln Lys Arg Gly Leu Ala Pro Gln 
        35                  40                  45              


Asn Lys Pro Glu Leu Gln Lys Val Met Glu Lys Arg Lys Arg Asp Gln 
    50                  55                  60                  


Val Ile Lys Gln Lys Glu Glu Glu Ala Gln Lys Lys Lys Ser Asp Leu 
65                  70                  75                  80  


Glu Ile Glu Leu 
                


<210>  4991
<211>  90
<212>  PRT
<213>  Homo Sapiens

<400>  4991

Met Ala Glu Pro Asp Tyr Ile Glu Asp Asp Asn Pro Glu Leu Ile Arg 
1               5                   10                  15      


Pro Gln Lys Leu Ile Asn Pro Val Lys Thr Ser Arg Asn His Gln Asp 
            20                  25                  30          


Leu His Arg Glu Leu Leu Met Asn Gln Lys Arg Gly Leu Ala Pro Gln 
        35                  40                  45              


Asn Lys Pro Glu Leu Gln Lys Val Met Glu Lys Arg Lys Arg Asp Gln 
    50                  55                  60                  


Val Ile Lys Gln Lys Glu Glu Glu Ala Gln Lys Lys Lys Ser Asp Leu 
65                  70                  75                  80  


Glu Ile Glu Leu Leu Lys Arg Gln Gln Lys 
                85                  90  


<210>  4992
<211>  93
<212>  PRT
<213>  Homo Sapiens

<400>  4992

Met Ala Glu Pro Asp Tyr Ile Glu Asp Asp Asn Pro Glu Leu Ile Arg 
1               5                   10                  15      


Pro Gln Lys Leu Ile Asn Pro Val Lys Thr Ser Arg Asn His Gln Asp 
            20                  25                  30          


Leu His Arg Glu Leu Leu Met Asn Gln Lys Arg Gly Leu Ala Pro Gln 
        35                  40                  45              


Asn Lys Pro Glu Leu Gln Lys Val Met Glu Lys Arg Lys Arg Asp Gln 
    50                  55                  60                  


Val Ile Lys Gln Lys Glu Glu Glu Ala Gln Lys Lys Lys Ser Asp Leu 
65                  70                  75                  80  


Glu Ile Glu Leu Leu Lys Arg Gln Gln Lys Leu Glu Gln 
                85                  90              


<210>  4993
<211>  101
<212>  PRT
<213>  Homo Sapiens

<400>  4993

Met Ala Glu Pro Asp Tyr Ile Glu Asp Asp Asn Pro Glu Leu Ile Arg 
1               5                   10                  15      


Pro Gln Lys Leu Ile Asn Pro Val Lys Thr Ser Arg Asn His Gln Asp 
            20                  25                  30          


Leu His Arg Glu Leu Leu Met Asn Gln Lys Arg Gly Leu Ala Pro Gln 
        35                  40                  45              


Asn Lys Pro Glu Leu Gln Lys Val Met Glu Lys Arg Lys Arg Asp Gln 
    50                  55                  60                  


Val Ile Lys Gln Lys Glu Glu Glu Ala Gln Lys Lys Lys Ser Asp Leu 
65                  70                  75                  80  


Glu Ile Glu Leu Leu Lys Arg Gln Gln Lys Leu Glu Gln Leu Glu Leu 
                85                  90                  95      


Glu Lys Gln Lys Leu 
            100     


<210>  4994
<211>  125
<212>  PRT
<213>  Homo Sapiens

<400>  4994

Met Ala Glu Pro Asp Tyr Ile Glu Asp Asp Asn Pro Glu Leu Ile Arg 
1               5                   10                  15      


Pro Gln Lys Leu Ile Asn Pro Val Lys Thr Ser Arg Asn His Gln Asp 
            20                  25                  30          


Leu His Arg Glu Leu Leu Met Asn Gln Lys Arg Gly Leu Ala Pro Gln 
        35                  40                  45              


Asn Lys Pro Glu Leu Gln Lys Val Met Glu Lys Arg Lys Arg Asp Gln 
    50                  55                  60                  


Val Ile Lys Gln Lys Glu Glu Glu Ala Gln Lys Lys Lys Ser Asp Leu 
65                  70                  75                  80  


Glu Ile Glu Leu Leu Lys Arg Gln Gln Lys Leu Glu Gln Leu Glu Leu 
                85                  90                  95      


Glu Lys Gln Lys Leu Gln Glu Glu Gln Glu Asn Ala Pro Glu Phe Val 
            100                 105                 110         


Lys Val Lys Gly Asn Leu Arg Arg Thr Gly Gln Glu Val 
        115                 120                 125 


<210>  4995
<211>  126
<212>  PRT
<213>  Homo Sapiens

<400>  4995

Met Ala Glu Pro Asp Tyr Ile Glu Asp Asp Asn Pro Glu Leu Ile Arg 
1               5                   10                  15      


Pro Gln Lys Leu Ile Asn Pro Val Lys Thr Ser Arg Asn His Gln Asp 
            20                  25                  30          


Leu His Arg Glu Leu Leu Met Asn Gln Lys Arg Gly Leu Ala Pro Gln 
        35                  40                  45              


Asn Lys Pro Glu Leu Gln Lys Val Met Glu Lys Arg Lys Arg Asp Gln 
    50                  55                  60                  


Val Ile Lys Gln Lys Glu Glu Glu Ala Gln Lys Lys Lys Ser Asp Leu 
65                  70                  75                  80  


Glu Ile Glu Leu Leu Lys Arg Gln Gln Lys Leu Glu Gln Leu Glu Leu 
                85                  90                  95      


Glu Lys Gln Lys Leu Gln Glu Glu Gln Glu Asn Ala Pro Glu Phe Val 
            100                 105                 110         


Lys Val Lys Gly Asn Leu Arg Arg Thr Gly Gln Glu Val Ala 
        115                 120                 125     


<210>  4996
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  4996

Met Ala Glu Pro Asp Tyr Ile Glu Asp Asp Asn Pro Glu Leu Ile Arg 
1               5                   10                  15      


Pro Gln Lys Leu Ile Asn Pro Val Lys Thr Ser Arg Asn His Gln Asp 
            20                  25                  30          


Leu His Arg Glu Leu Leu Met Asn Gln Lys Arg Gly Leu Ala Pro Gln 
        35                  40                  45              


Asn Lys Pro Glu Leu Gln Lys Val Met Glu Lys Arg Lys Arg Asp Gln 
    50                  55                  60                  


Val Ile Lys Gln Lys Glu Glu Glu Ala Gln Lys Lys Lys Ser Asp Leu 
65                  70                  75                  80  


Glu Ile Glu Leu Leu Lys Arg Gln Gln Lys Leu Glu Gln Leu Glu Leu 
                85                  90                  95      


Glu Lys Gln Lys Leu Gln Glu Glu Gln Glu Asn Ala Pro Glu Phe Val 
            100                 105                 110         


Lys Val Lys Gly Asn Leu Arg Arg Thr Gly Gln Glu Val Ala Gln Ala 
        115                 120                 125             


<210>  4997
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  4997

Met Ala Glu Pro Asp Tyr Ile Glu Asp Asp Asn Pro Glu Leu Ile Arg 
1               5                   10                  15      


Pro Gln Lys Leu Ile Asn Pro Val Lys Thr Ser Arg Asn His Gln Asp 
            20                  25                  30          


Leu His Arg Glu Leu Leu Met Asn Gln Lys Arg Gly Leu Ala Pro Gln 
        35                  40                  45              


Asn Lys Pro Glu Leu Gln Lys Val Met Glu Lys Arg Lys Arg Asp Gln 
    50                  55                  60                  


Val Ile Lys Gln Lys Glu Glu Glu Ala Gln Lys Lys Lys Ser Asp Leu 
65                  70                  75                  80  


Glu Ile Glu Leu Leu Lys Arg Gln Gln Lys Leu Glu Gln Leu Glu Leu 
                85                  90                  95      


Glu Lys Gln Lys Leu Gln Glu Glu Gln Glu Asn Ala Pro Glu Phe Val 
            100                 105                 110         


Lys Val Lys Gly Asn Leu Arg Arg Thr Gly Gln Glu Val Ala Gln Ala 
        115                 120                 125             


Gln Glu Ser 
    130     


<210>  4998
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  4998

Met Ala Glu Pro Asp Tyr Ile Glu Asp Asp Asn Pro Glu Leu Ile Arg 
1               5                   10                  15      


Pro Gln Lys Leu Ile Asn Pro Val Lys Thr Ser Arg Asn His Gln Asp 
            20                  25                  30          


Leu His Arg Glu Leu Leu Met Asn Gln Lys Arg Gly Leu Ala Pro Gln 
        35                  40                  45              


Asn Lys Pro Glu Leu Gln Lys Val Met Glu Lys Arg Lys Arg Asp Gln 
    50                  55                  60                  


Val Ile Lys Gln Lys Glu Glu Glu Ala Gln Lys Lys Lys Ser Asp Leu 
65                  70                  75                  80  


Glu Ile Glu Leu Leu Lys Arg Gln Gln Lys Leu Glu Gln Leu Glu Leu 
                85                  90                  95      


Glu Lys Gln Lys Leu Gln Glu Glu Gln Glu Asn Ala Pro Glu Phe Val 
            100                 105                 110         


Lys Val Lys Gly Asn Leu Arg Arg Thr Gly Gln Glu Val Ala Gln Ala 
        115                 120                 125             


Gln Glu Ser 
    130     


<210>  4999
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  4999

Met Ala Glu Pro Asp Tyr Ile Glu Asp Asp Asn Pro Glu Leu Ile Arg 
1               5                   10                  15      


Pro Gln Lys Leu Ile Asn Pro Val Lys Thr Ser Arg Asn His Gln Asp 
            20                  25                  30          


Leu His Arg Glu Leu Leu Met Asn Gln Lys Arg Gly Leu Ala Pro Gln 
        35                  40                  45              


Asn Lys Pro Glu Leu Gln Lys Val Met Glu Lys Arg Lys Arg Asp Gln 
    50                  55                  60                  


Val Ile Lys Gln Lys Glu Glu Glu Ala Gln Lys Lys Lys Ser Asp Leu 
65                  70                  75                  80  


Glu Ile Glu Leu Leu Lys Arg Gln Gln Lys Leu Glu Gln Leu Glu Leu 
                85                  90                  95      


Glu Lys Gln Lys Leu Gln Glu Glu Gln Glu Asn Ala Pro Glu Phe Val 
            100                 105                 110         


Lys Val Lys Gly Asn Leu Arg Arg Thr Gly Gln Glu Val Ala Gln Ala 
        115                 120                 125             


Gln Glu Ser 
    130     


<210>  5000
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  5000

Met Ala Glu Pro Asp Tyr Ile Glu Asp Asp Asn Pro Glu Leu Ile Arg 
1               5                   10                  15      


Pro Gln Lys Leu Ile Asn Pro Val Lys Thr Ser Arg Asn His Gln Asp 
            20                  25                  30          


Leu His Arg Glu Leu Leu Met Asn Gln Lys Arg Gly Leu Ala Pro Gln 
        35                  40                  45              


Asn Lys Pro Glu Leu Gln Lys Val Met Glu Lys Arg Lys Arg Asp Gln 
    50                  55                  60                  


Val Ile Lys Gln Lys Glu Glu Glu Ala Gln Lys Lys Lys Ser Asp Leu 
65                  70                  75                  80  


Glu Ile Glu Leu Leu Lys Arg Gln Gln Lys Leu Glu Gln Leu Glu Leu 
                85                  90                  95      


Glu Lys Gln Lys Leu Gln Glu Glu Gln Glu Asn Ala Pro Glu Phe Val 
            100                 105                 110         


Lys Val Lys Gly Asn Leu Arg Arg Thr Gly Gln Glu Val Ala Gln Ala 
        115                 120                 125             


Gln Glu Ser 
    130     


<210>  5001
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  5001

Met Ala Glu Pro Asp Tyr Ile Glu Asp Asp Asn Pro Glu Leu Ile Arg 
1               5                   10                  15      


Pro Gln Lys Leu Ile Asn Pro Val Lys Thr Ser Arg Asn His Gln Asp 
            20                  25                  30          


Leu His Arg Glu Leu Leu Met Asn Gln Lys Arg Gly Leu Ala Pro Gln 
        35                  40                  45              


Asn Lys Pro Glu Leu Gln Lys Val Met Glu Lys Arg Lys Arg Asp Gln 
    50                  55                  60                  


Val Ile Lys Gln Lys Glu Glu Glu Ala Gln Lys Lys Lys Ser Asp Leu 
65                  70                  75                  80  


Glu Ile Glu Leu Leu Lys Arg Gln Gln Lys Leu Glu Gln Leu Glu Leu 
                85                  90                  95      


Glu Lys Gln Lys Leu Gln Glu Glu Gln Glu Asn Ala Pro Glu Phe Val 
            100                 105                 110         


Lys Val Lys Gly Asn Leu Arg Arg Thr Gly Gln Glu Val Ala Gln Ala 
        115                 120                 125             


Gln Glu Ser 
    130     


<210>  5002
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  5002

Met Ala Glu Pro Asp Tyr Ile Glu Asp Asp Asn Pro Glu Leu Ile Arg 
1               5                   10                  15      


Pro Gln Lys Leu Ile Asn Pro Val Lys Thr Ser Arg Asn His Gln Asp 
            20                  25                  30          


Leu His Arg Glu Leu Leu Met Asn Gln Lys Arg Gly Leu Ala Pro Gln 
        35                  40                  45              


Asn Lys Pro Glu Leu Gln Lys Val Met Glu Lys Arg Lys Arg Asp Gln 
    50                  55                  60                  


Val Ile Lys Gln Lys Glu Glu Glu Ala Gln Lys Lys Lys Ser Asp Leu 
65                  70                  75                  80  


Glu Ile Glu Leu Leu Lys Arg Gln Gln Lys Leu Glu Gln Leu Glu Leu 
                85                  90                  95      


Glu Lys Gln Lys Leu Gln Glu Glu Gln Glu Asn Ala Pro Glu Phe Val 
            100                 105                 110         


Lys Val Lys Gly Asn Leu Arg Arg Thr Gly Gln Glu Val Ala Gln Ala 
        115                 120                 125             


Gln Glu Ser 
    130     


<210>  5003
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  5003

Met Ala Glu Pro Asp Tyr Ile Glu Asp Asp Asn Pro Glu Leu Ile Arg 
1               5                   10                  15      


Pro Gln Lys Leu Ile Asn Pro Val Lys Thr Ser Arg Asn His Gln Asp 
            20                  25                  30          


Leu His Arg Glu Leu Leu Met Asn Gln Lys Arg Gly Leu Ala Pro Gln 
        35                  40                  45              


Asn Lys Pro Glu Leu Gln Lys Val Met Glu Lys Arg Lys Arg Asp Gln 
    50                  55                  60                  


Val Ile Lys Gln Lys Glu Glu Glu Ala Gln Lys Lys Lys Ser Asp Leu 
65                  70                  75                  80  


Glu Ile Glu Leu Leu Lys Arg Gln Gln Lys Leu Glu Gln Leu Glu Leu 
                85                  90                  95      


Glu Lys Gln Lys Leu Gln Glu Glu Gln Glu Asn Ala Pro Glu Phe Val 
            100                 105                 110         


Lys Val Lys Gly Asn Leu Arg Arg Thr Gly Gln Glu Val Ala Gln Ala 
        115                 120                 125             


Gln Glu Ser 
    130     


<210>  5004
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  5004

Met Ala Glu Pro Asp Tyr Ile Glu Asp Asp Asn Pro Glu Leu Ile Arg 
1               5                   10                  15      


Pro Gln Lys Leu Ile Asn Pro Val Lys Thr Ser Arg Asn His Gln Asp 
            20                  25                  30          


Leu His Arg Glu Leu Leu Met Asn Gln Lys Arg Gly Leu Ala Pro Gln 
        35                  40                  45              


Asn Lys Pro Glu Leu Gln Lys Val Met Glu Lys Arg Lys Arg Asp Gln 
    50                  55                  60                  


Val Ile Lys Gln Lys Glu Glu Glu Ala Gln Lys Lys Lys Ser Asp Leu 
65                  70                  75                  80  


Glu Ile Glu Leu Leu Lys Arg Gln Gln Lys Leu Glu Gln Leu Glu Leu 
                85                  90                  95      


Glu Lys Gln Lys Leu Gln Glu Glu Gln Glu Asn Ala Pro Glu Phe Val 
            100                 105                 110         


Lys Val Lys Gly Asn Leu Arg Arg Thr Gly Gln Glu Val Ala Gln Ala 
        115                 120                 125             


Gln Glu Ser 
    130     


<210>  5005
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  5005

Met Ala Glu Pro Asp Tyr Ile Glu Asp Asp Asn Pro Glu Leu Ile Arg 
1               5                   10                  15      


Pro Gln Lys Leu Ile Asn Pro Val Lys Thr Ser Arg Asn His Gln Asp 
            20                  25                  30          


Leu His Arg Glu Leu Leu Met Asn Gln Lys Arg Gly Leu Ala Pro Gln 
        35                  40                  45              


Asn Lys Pro Glu Leu Gln Lys Val Met Glu Lys Arg Lys Arg Asp Gln 
    50                  55                  60                  


Val Ile Lys Gln Lys Glu Glu Glu Ala Gln Lys Lys Lys Ser Asp Leu 
65                  70                  75                  80  


Glu Ile Glu Leu Leu Lys Arg Gln Gln Lys Leu Glu Gln Leu Glu Leu 
                85                  90                  95      


Glu Lys Gln Lys Leu Gln Glu Glu Gln Glu Asn Ala Pro Glu Phe Val 
            100                 105                 110         


Lys Val Lys Gly Asn Leu Arg Arg Thr Gly Gln Glu Val Ala Gln Ala 
        115                 120                 125             


Gln Glu Ser 
    130     


<210>  5006
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  5006

Met Ala Glu Pro Asp Tyr Ile Glu Asp Asp Asn Pro Glu Leu Ile Arg 
1               5                   10                  15      


Pro Gln Lys Leu Ile Asn Pro Val Lys Thr Ser Arg Asn His Gln Asp 
            20                  25                  30          


Leu His Arg Glu Leu Leu Met Asn Gln Lys Arg Gly Leu Ala Pro Gln 
        35                  40                  45              


Asn Lys Pro Glu Leu Gln Lys Val Met Glu Lys Arg Lys Arg Asp Gln 
    50                  55                  60                  


Val Ile Lys Gln Lys Glu Glu Glu Ala Gln Lys Lys Lys Ser Asp Leu 
65                  70                  75                  80  


Glu Ile Glu Leu Leu Lys Arg Gln Gln Lys Leu Glu Gln Leu Glu Leu 
                85                  90                  95      


Glu Lys Gln Lys Leu Gln Glu Glu Gln Glu Asn Ala Pro Glu Phe Val 
            100                 105                 110         


Lys Val Lys Gly Asn Leu Arg Arg Thr Gly Gln Glu Val Ala Gln Ala 
        115                 120                 125             


Gln Glu Ser 
    130     


<210>  5007
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  5007

Met Ala Glu Pro Asp Tyr Ile Glu Asp Asp Asn Pro Glu Leu Ile Arg 
1               5                   10                  15      


Pro Gln Lys Leu Ile Asn Pro Val Lys Thr Ser Arg Asn His Gln Asp 
            20                  25                  30          


Leu His Arg Glu Leu Leu Met Asn Gln Lys Arg Gly Leu Ala Pro Gln 
        35                  40                  45              


Asn Lys Pro Glu Leu Gln Lys Val Met Glu Lys Arg Lys Arg Asp Gln 
    50                  55                  60                  


Val Ile Lys Gln Lys Glu Glu Glu Ala Gln Lys Lys Lys Ser Asp Leu 
65                  70                  75                  80  


Glu Ile Glu Leu Leu Lys Arg Gln Gln Lys Leu Glu Gln Leu Glu Leu 
                85                  90                  95      


Glu Lys Gln Lys Leu Gln Glu Glu Gln Glu Asn Ala Pro Glu Phe Val 
            100                 105                 110         


Lys Val Lys Gly Asn Leu Arg Arg Thr Gly Gln Glu Val Ala Gln Ala 
        115                 120                 125             


Gln Glu Ser 
    130     


<210>  5008
<211>  51
<212>  PRT
<213>  Homo Sapiens

<400>  5008

Met Ala Glu Pro Asp Tyr Ile Glu Asp Asp Asn Pro Glu Leu Ile Arg 
1               5                   10                  15      


Pro Gln Lys Leu Ile Asn Pro Val Lys Thr Ser Arg Asn His Gln Asp 
            20                  25                  30          


Leu His Arg Glu Leu Leu Met Asn Gln Lys Arg Ile Leu Val Trp Leu 
        35                  40                  45              


Glu Ile His 
    50      


<210>  5009
<211>  306
<212>  PRT
<213>  Homo Sapiens

<400>  5009

Met Ser Thr Trp Lys Ala Arg Leu Thr Lys Arg Leu Lys Ser Pro Ser 
1               5                   10                  15      


Arg Ser Met His Pro Phe Pro Cys Ser Ala Leu Leu Ala Cys Phe Gly 
            20                  25                  30          


Asn Thr Arg Glu Ser Ala Ser Phe Asn Gln Ser Gly Val Ala Asp Thr 
        35                  40                  45              


His Ser Thr Val Arg Val Gln Pro Val Ala Lys Ala Gly Arg Gln Pro 
    50                  55                  60                  


Arg His Pro Ser Ala Glu Gly Ala Pro Glu Lys Arg Gln Asp Ser Ser 
65                  70                  75                  80  


Thr His Ala Glu Arg Asn Gly Ser Ala Asn Arg Asn Ser Ser His Arg 
                85                  90                  95      


Thr Ala Ala Gln Pro Ala Glu Thr Pro Glu Asp Val Pro Gly Ser Leu 
            100                 105                 110         


Asp Asp Gly Ala Asp Cys Glu Ala Val Val Phe His Ala Ser Ile Pro 
        115                 120                 125             


Arg Pro Ser Ile Ile Asp Thr Pro Lys Glu Glu Glu Phe Arg Glu Glu 
    130                 135                 140                 


Pro Lys Cys Leu Glu Leu Glu Gln Lys Met Thr Ser Asp Ser Pro Pro 
145                 150                 155                 160 


Glu Asp Ile Asp His Lys Asp Ser Tyr Leu Ile Thr Arg Ser Ile Met 
                165                 170                 175     


Ala Glu Pro Asp Tyr Ile Glu Asp Asp Asn Pro Glu Leu Ile Arg Pro 
            180                 185                 190         


Gln Lys Leu Ile Asn Pro Val Lys Thr Ser Arg Asn His Gln Asp Leu 
        195                 200                 205             


His Arg Glu Leu Leu Met Asn Gln Lys Arg Gly Leu Ala Pro Gln Asn 
    210                 215                 220                 


Lys Pro Glu Leu Gln Lys Val Met Glu Lys Arg Lys Arg Asp Gln Val 
225                 230                 235                 240 


Ile Lys Gln Lys Glu Glu Glu Ala Gln Lys Lys Lys Ser Asp Leu Glu 
                245                 250                 255     


Ile Glu Leu Leu Lys Arg Gln Gln Lys Leu Glu Gln Leu Glu Leu Glu 
            260                 265                 270         


Lys Gln Lys Leu Gln Glu Glu Gln Glu Asn Ala Pro Glu Phe Val Lys 
        275                 280                 285             


Val Lys Gly Asn Leu Arg Arg Thr Gly Gln Glu Val Ala Gln Ala Gln 
    290                 295                 300                 


Glu Ser 
305     


<210>  5010
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  5010

Met Ser Thr Trp Lys Ala Arg Leu Thr Lys Arg Leu Lys Ser Pro Ser 
1               5                   10                  15      


Arg Ser Met His Pro Phe Pro Cys Ser Ala Leu Leu Ala Cys Phe Gly 
            20                  25                  30          


Asn Thr Arg Glu Ser Ala Ser Phe Asn Gln Ser Gly Val Ala Asp Thr 
        35                  40                  45              


His Ser Thr Val Arg Val Gln Pro Val Ala Lys Ala Gly Arg Gln Pro 
    50                  55                  60                  


Arg His Pro Ser Ala Glu Gly Ala Pro Glu Lys Arg Gln Asp Ser Ser 
65                  70                  75                  80  


Thr His Ala Glu Arg Asn Gly Ser Ala Asn Arg Asn Ser Ser His Arg 
                85                  90                  95      


Thr Ala Ala Gln Pro Ala Glu Thr Pro Glu Asp Val Pro Gly Ser Leu 
            100                 105                 110         


Asp Asp Gly Ala Asp Cys Glu Ala Val Val Phe His Ala Ser Ile Pro 
        115                 120                 125             


Arg Pro Ser Ile Ile Asp Thr Pro Lys Glu Glu Glu Phe Arg Glu Glu 
    130                 135                 140                 


Pro Lys Cys Leu Glu Leu Glu Gln Lys Met Thr Ser Gly Glu Cys Ser 
145                 150                 155                 160 


<210>  5011
<211>  251
<212>  PRT
<213>  Homo Sapiens

<400>  5011

Met Ala Gln Gly Arg Val Ala His Leu Ile Glu Trp Lys Gly Trp Ser 
1               5                   10                  15      


Lys Pro Ser Asp Ser Pro Ala Ala Leu Glu Ser Ala Phe Ser Ser Tyr 
            20                  25                  30          


Ser Asp Leu Ser Glu Gly Glu Gln Glu Ala Arg Phe Ala Ala Gly Val 
        35                  40                  45              


Ala Glu Gln Phe Ala Ile Ala Glu Ala Lys Leu Arg Ala Trp Ser Ser 
    50                  55                  60                  


Val Asp Gly Glu Asp Ser Thr Asp Asp Ser Tyr Asp Glu Asp Phe Ala 
65                  70                  75                  80  


Gly Gly Met Asp Thr Asp Met Ala Gly Gln Leu Pro Leu Gly Pro His 
                85                  90                  95      


Leu Gln Asp Leu Phe Thr Gly His Arg Phe Ser Arg Pro Val Arg Gln 
            100                 105                 110         


Gly Ser Val Glu Pro Glu Ser Asp Cys Ser Gln Thr Val Ser Pro Asp 
        115                 120                 125             


Thr Leu Cys Ser Ser Leu Cys Ser Leu Glu Asp Gly Leu Leu Gly Ser 
    130                 135                 140                 


Pro Ala Arg Leu Ala Ser Gln Leu Leu Gly Asp Glu Leu Leu Leu Ala 
145                 150                 155                 160 


Lys Leu Pro Pro Ser Arg Glu Ser Ala Phe Arg Ser Leu Gly Pro Leu 
                165                 170                 175     


Glu Ala Gln Asp Ser Leu Tyr Asn Ser Pro Leu Thr Glu Gly Trp Leu 
            180                 185                 190         


Leu Pro Ser Arg Ser Leu Trp Val Glu Pro Ser Leu Lys Gly Pro Cys 
        195                 200                 205             


Pro Ala Gly Leu Val Leu Cys Phe Ile His Leu Ser Ile Val Ser Lys 
    210                 215                 220                 


Ser Ser Ser Phe Phe Leu Lys Thr Glu Gly Phe Trp Ser Val Phe Ser 
225                 230                 235                 240 


Val Gly Ser Ser Leu Leu Trp Glu Ala Leu Glu 
                245                 250     


<210>  5012
<211>  335
<212>  PRT
<213>  Homo Sapiens

<400>  5012

Met Phe Leu Ala Thr Leu Ser Phe Leu Leu Pro Phe Ala His Pro Phe 
1               5                   10                  15      


Gly Thr Val Ser Cys Glu Tyr Met Leu Gly Ser Pro Leu Ser Ser Leu 
            20                  25                  30          


Ala Gln Val Asn Leu Ser Pro Phe Ser His Pro Lys Val His Met Asp 
        35                  40                  45              


Pro Asn Tyr Cys His Pro Ser Thr Ser Leu His Leu Cys Ser Leu Ala 
    50                  55                  60                  


Trp Ser Phe Thr Arg Leu Leu His Pro Pro Leu Ser Pro Gly Ile Ser 
65                  70                  75                  80  


Gln Val Val Lys Asp His Val Thr Lys Pro Thr Ala Met Ala Gln Gly 
                85                  90                  95      


Arg Val Ala His Leu Ile Glu Trp Lys Gly Trp Ser Lys Pro Ser Asp 
            100                 105                 110         


Ser Pro Ala Ala Leu Glu Ser Ala Phe Ser Ser Tyr Ser Asp Leu Ser 
        115                 120                 125             


Glu Gly Glu Gln Glu Ala Arg Phe Ala Ala Gly Val Ala Glu Gln Phe 
    130                 135                 140                 


Ala Ile Ala Glu Ala Lys Leu Arg Ala Trp Ser Ser Val Asp Gly Glu 
145                 150                 155                 160 


Asp Ser Thr Asp Asp Ser Tyr Asp Glu Asp Phe Ala Gly Gly Met Asp 
                165                 170                 175     


Thr Asp Met Ala Gly Gln Leu Pro Leu Gly Pro His Leu Gln Asp Leu 
            180                 185                 190         


Phe Thr Gly His Arg Phe Ser Arg Pro Val Arg Gln Gly Ser Val Glu 
        195                 200                 205             


Pro Glu Ser Asp Cys Ser Gln Thr Val Ser Pro Asp Thr Leu Cys Ser 
    210                 215                 220                 


Ser Leu Cys Ser Leu Glu Asp Gly Leu Leu Gly Ser Pro Ala Arg Leu 
225                 230                 235                 240 


Ala Ser Gln Leu Leu Gly Asp Glu Leu Leu Leu Ala Lys Leu Pro Pro 
                245                 250                 255     


Ser Arg Glu Ser Ala Phe Arg Ser Leu Gly Pro Leu Glu Ala Gln Asp 
            260                 265                 270         


Ser Leu Tyr Asn Ser Pro Leu Thr Glu Ser Cys Leu Ser Pro Ala Glu 
        275                 280                 285             


Glu Glu Pro Ala Pro Cys Lys Asp Cys Gln Pro Leu Cys Pro Pro Leu 
    290                 295                 300                 


Thr Gly Ser Trp Glu Arg Gln Arg Gln Ala Ser Asp Leu Ala Ser Ser 
305                 310                 315                 320 


Gly Val Val Ser Leu Asp Glu Asp Glu Ala Glu Pro Glu Glu Gln 
                325                 330                 335 


<210>  5013
<211>  123
<212>  PRT
<213>  Homo Sapiens

<400>  5013

Met Leu Pro Lys Ser Arg Arg Ala Leu Thr Ile Gln Glu Ile Ala Ala 
1               5                   10                  15      


Leu Ala Arg Ser Ser Leu His Gly Ile Ser Gln Val Val Lys Asp His 
            20                  25                  30          


Val Thr Lys Pro Thr Ala Met Ala Gln Gly Arg Val Ala His Leu Ile 
        35                  40                  45              


Glu Trp Lys Gly Trp Ser Lys Pro Ser Asp Ser Pro Ala Ala Leu Glu 
    50                  55                  60                  


Ser Ala Phe Ser Ser Tyr Ser Asp Leu Ser Glu Gly Glu Gln Glu Ala 
65                  70                  75                  80  


Arg Phe Ala Ala Gly Val Ala Glu Gln Phe Ala Ile Ala Glu Ala Lys 
                85                  90                  95      


Leu Arg Ala Trp Ser Ser Val Asp Gly Glu Asp Ser Thr Asp Asp Ser 
            100                 105                 110         


Tyr Asp Glu Asp Phe Ala Gly Gly Met Asp Thr 
        115                 120             


<210>  5014
<211>  232
<212>  PRT
<213>  Homo Sapiens

<400>  5014

Met Leu Pro Lys Ser Arg Arg Ala Leu Thr Ile Gln Glu Ile Ala Ala 
1               5                   10                  15      


Leu Ala Arg Ser Ser Leu His Gly Ile Ser Gln Val Val Lys Asp His 
            20                  25                  30          


Val Thr Lys Pro Thr Ala Met Ala Gln Gly Arg Val Ala His Leu Ile 
        35                  40                  45              


Glu Trp Lys Gly Trp Ser Lys Pro Ser Asp Ser Pro Ala Ala Leu Glu 
    50                  55                  60                  


Ser Ala Phe Ser Ser Tyr Ser Asp Leu Ser Glu Gly Glu Gln Glu Ala 
65                  70                  75                  80  


Arg Phe Ala Ala Gly Val Ala Glu Gln Phe Ala Ile Ala Glu Ala Lys 
                85                  90                  95      


Leu Arg Ala Trp Ser Ser Val Asp Gly Glu Asp Ser Thr Asp Asp Ser 
            100                 105                 110         


Tyr Asp Glu Asp Phe Ala Gly Gly Met Asp Thr Asp Met Ala Gly Gln 
        115                 120                 125             


Leu Pro Leu Gly Pro His Leu Gln Asp Leu Phe Thr Gly His Arg Phe 
    130                 135                 140                 


Ser Arg Pro Val Arg Gln Gly Ser Val Glu Pro Glu Ser Asp Cys Ser 
145                 150                 155                 160 


Gln Thr Val Ser Pro Asp Thr Leu Cys Ser Ser Leu Cys Ser Leu Glu 
                165                 170                 175     


Asp Gly Leu Leu Gly Ser Pro Ala Arg Leu Ala Ser Gln Leu Leu Gly 
            180                 185                 190         


Asp Glu Leu Leu Leu Ala Lys Leu Pro Pro Ser Arg Glu Ser Ala Phe 
        195                 200                 205             


Arg Ser Leu Gly Pro Leu Glu Ala Gln Asp Ser Leu Tyr Asn Ser Pro 
    210                 215                 220                 


Leu Thr Glu Ser Cys Leu Ser Pro 
225                 230         


<210>  5015
<211>  281
<212>  PRT
<213>  Homo Sapiens

<400>  5015

Met Leu Pro Lys Ser Arg Arg Ala Leu Thr Ile Gln Glu Ile Ala Ala 
1               5                   10                  15      


Leu Ala Arg Ser Ser Leu His Gly Ile Ser Gln Val Val Lys Asp His 
            20                  25                  30          


Val Thr Lys Pro Thr Ala Met Ala Gln Gly Arg Val Ala His Leu Ile 
        35                  40                  45              


Glu Trp Lys Gly Trp Ser Lys Pro Ser Asp Ser Pro Ala Ala Leu Glu 
    50                  55                  60                  


Ser Ala Phe Ser Ser Tyr Ser Asp Leu Ser Glu Gly Glu Gln Glu Ala 
65                  70                  75                  80  


Arg Phe Ala Ala Gly Val Ala Glu Gln Phe Ala Ile Ala Glu Ala Lys 
                85                  90                  95      


Leu Arg Ala Trp Ser Ser Val Asp Gly Glu Asp Ser Thr Asp Asp Ser 
            100                 105                 110         


Tyr Asp Glu Asp Phe Ala Gly Gly Met Asp Thr Asp Met Ala Gly Gln 
        115                 120                 125             


Leu Pro Leu Gly Pro His Leu Gln Asp Leu Phe Thr Gly His Arg Phe 
    130                 135                 140                 


Ser Arg Pro Val Arg Gln Gly Ser Val Glu Pro Glu Ser Asp Cys Ser 
145                 150                 155                 160 


Gln Thr Val Ser Pro Asp Thr Leu Cys Ser Ser Leu Cys Ser Leu Glu 
                165                 170                 175     


Asp Gly Leu Leu Gly Ser Pro Ala Arg Leu Ala Ser Gln Leu Leu Gly 
            180                 185                 190         


Asp Glu Leu Leu Leu Ala Lys Leu Pro Pro Ser Arg Glu Ser Ala Phe 
        195                 200                 205             


Arg Ser Leu Gly Pro Leu Glu Ala Gln Asp Ser Leu Tyr Asn Ser Pro 
    210                 215                 220                 


Leu Thr Glu Ser Cys Leu Ser Pro Ala Glu Glu Glu Pro Ala Pro Cys 
225                 230                 235                 240 


Lys Asp Cys Gln Pro Leu Cys Pro Pro Leu Thr Gly Ser Trp Glu Arg 
                245                 250                 255     


Gln Arg Gln Ala Ser Asp Leu Ala Ser Ser Gly Val Val Ser Leu Asp 
            260                 265                 270         


Glu Asp Glu Ala Glu Pro Glu Glu Gln 
        275                 280     


<210>  5016
<211>  281
<212>  PRT
<213>  Homo Sapiens

<400>  5016

Met Leu Pro Lys Ser Arg Arg Ala Leu Thr Ile Gln Glu Ile Ala Ala 
1               5                   10                  15      


Leu Ala Arg Ser Ser Leu His Gly Ile Ser Gln Val Val Lys Asp His 
            20                  25                  30          


Val Thr Lys Pro Thr Ala Met Ala Gln Gly Arg Val Ala His Leu Ile 
        35                  40                  45              


Glu Trp Lys Gly Trp Ser Lys Pro Ser Asp Ser Pro Ala Ala Leu Glu 
    50                  55                  60                  


Ser Ala Phe Ser Ser Tyr Ser Asp Leu Ser Glu Gly Glu Gln Glu Ala 
65                  70                  75                  80  


Arg Phe Ala Ala Gly Val Ala Glu Gln Phe Ala Ile Ala Glu Ala Lys 
                85                  90                  95      


Leu Arg Ala Trp Ser Ser Val Asp Gly Glu Asp Ser Thr Asp Asp Ser 
            100                 105                 110         


Tyr Asp Glu Asp Phe Ala Gly Gly Met Asp Thr Asp Met Ala Gly Gln 
        115                 120                 125             


Leu Pro Leu Gly Pro His Leu Gln Asp Leu Phe Thr Gly His Arg Phe 
    130                 135                 140                 


Ser Arg Pro Val Arg Gln Gly Ser Val Glu Pro Glu Ser Asp Cys Ser 
145                 150                 155                 160 


Gln Thr Val Ser Pro Asp Thr Leu Cys Ser Ser Leu Cys Ser Leu Glu 
                165                 170                 175     


Asp Gly Leu Leu Gly Ser Pro Ala Arg Leu Ala Ser Gln Leu Leu Gly 
            180                 185                 190         


Asp Glu Leu Leu Leu Ala Lys Leu Pro Pro Ser Arg Glu Ser Ala Phe 
        195                 200                 205             


Arg Ser Leu Gly Pro Leu Glu Ala Gln Asp Ser Leu Tyr Asn Ser Pro 
    210                 215                 220                 


Leu Thr Glu Ser Cys Leu Ser Pro Ala Glu Glu Glu Pro Ala Pro Cys 
225                 230                 235                 240 


Lys Asp Cys Gln Pro Leu Cys Pro Pro Leu Thr Gly Ser Trp Glu Arg 
                245                 250                 255     


Gln Arg Gln Ala Ser Asp Leu Ala Ser Ser Gly Val Val Ser Leu Asp 
            260                 265                 270         


Glu Asp Glu Ala Glu Pro Glu Glu Gln 
        275                 280     


<210>  5017
<211>  281
<212>  PRT
<213>  Homo Sapiens

<400>  5017

Met Leu Pro Lys Ser Arg Arg Ala Leu Thr Ile Gln Glu Ile Ala Ala 
1               5                   10                  15      


Leu Ala Arg Ser Ser Leu His Gly Ile Ser Gln Val Val Lys Asp His 
            20                  25                  30          


Val Thr Lys Pro Thr Ala Met Ala Gln Gly Arg Val Ala His Leu Ile 
        35                  40                  45              


Glu Trp Lys Gly Trp Ser Lys Pro Ser Asp Ser Pro Ala Ala Leu Glu 
    50                  55                  60                  


Ser Ala Phe Ser Ser Tyr Ser Asp Leu Ser Glu Gly Glu Gln Glu Ala 
65                  70                  75                  80  


Arg Phe Ala Ala Gly Val Ala Glu Gln Phe Ala Ile Ala Glu Ala Lys 
                85                  90                  95      


Leu Arg Ala Trp Ser Ser Val Asp Gly Glu Asp Ser Thr Asp Asp Ser 
            100                 105                 110         


Tyr Asp Glu Asp Phe Ala Gly Gly Met Asp Thr Asp Met Ala Gly Gln 
        115                 120                 125             


Leu Pro Leu Gly Pro His Leu Gln Asp Leu Phe Thr Gly His Arg Phe 
    130                 135                 140                 


Ser Arg Pro Val Arg Gln Gly Ser Val Glu Pro Glu Ser Asp Cys Ser 
145                 150                 155                 160 


Gln Thr Val Ser Pro Asp Thr Leu Cys Ser Ser Leu Cys Ser Leu Glu 
                165                 170                 175     


Asp Gly Leu Leu Gly Ser Pro Ala Arg Leu Ala Ser Gln Leu Leu Gly 
            180                 185                 190         


Asp Glu Leu Leu Leu Ala Lys Leu Pro Pro Ser Arg Glu Ser Ala Phe 
        195                 200                 205             


Arg Ser Leu Gly Pro Leu Glu Ala Gln Asp Ser Leu Tyr Asn Ser Pro 
    210                 215                 220                 


Leu Thr Glu Ser Cys Leu Ser Pro Ala Glu Glu Glu Pro Ala Pro Cys 
225                 230                 235                 240 


Lys Asp Cys Gln Pro Leu Cys Pro Pro Leu Thr Gly Ser Trp Glu Arg 
                245                 250                 255     


Gln Arg Gln Ala Ser Asp Leu Ala Ser Ser Gly Val Val Ser Leu Asp 
            260                 265                 270         


Glu Asp Glu Ala Glu Pro Glu Glu Gln 
        275                 280     


<210>  5018
<211>  366
<212>  PRT
<213>  Homo Sapiens

<400>  5018

Met Pro Met Ile Ser Val Leu Gly Lys Met Phe Leu Trp Gln Arg Glu 
1               5                   10                  15      


Gly Pro Gly Gly Arg Trp Thr Cys Gln Thr Ser Arg Arg Val Ser Ser 
            20                  25                  30          


Asp Pro Ala Trp Ala Val Glu Trp Ile Glu Leu Pro Arg Gly Leu Ser 
        35                  40                  45              


Leu Ser Ser Leu Gly Ser Ala Arg Thr Leu Arg Gly Trp Ser Arg Ser 
    50                  55                  60                  


Ser Arg Pro Ser Ser Val Asp Ser Gln Asp Leu Pro Glu Val Asn Val 
65                  70                  75                  80  


Gly Asp Thr Val Ala Met Leu Pro Lys Ser Arg Arg Ala Leu Thr Ile 
                85                  90                  95      


Gln Glu Ile Ala Ala Leu Ala Arg Ser Ser Leu His Gly Ile Ser Gln 
            100                 105                 110         


Val Val Lys Asp His Val Thr Lys Pro Thr Ala Met Ala Gln Gly Arg 
        115                 120                 125             


Val Ala His Leu Ile Glu Trp Lys Gly Trp Ser Lys Pro Ser Asp Ser 
    130                 135                 140                 


Pro Ala Ala Leu Glu Ser Ala Phe Ser Ser Tyr Ser Asp Leu Ser Glu 
145                 150                 155                 160 


Gly Glu Gln Glu Ala Arg Phe Ala Ala Gly Val Ala Glu Gln Phe Ala 
                165                 170                 175     


Ile Ala Glu Ala Lys Leu Arg Ala Trp Ser Ser Val Asp Gly Glu Asp 
            180                 185                 190         


Ser Thr Asp Asp Ser Tyr Asp Glu Asp Phe Ala Gly Gly Met Asp Thr 
        195                 200                 205             


Asp Met Ala Gly Gln Leu Pro Leu Gly Pro His Leu Gln Asp Leu Phe 
    210                 215                 220                 


Thr Gly His Arg Phe Ser Arg Pro Val Arg Gln Gly Ser Val Glu Pro 
225                 230                 235                 240 


Glu Ser Asp Cys Ser Gln Thr Val Ser Pro Asp Thr Leu Cys Ser Ser 
                245                 250                 255     


Leu Cys Ser Leu Glu Asp Gly Leu Leu Gly Ser Pro Ala Arg Leu Ala 
            260                 265                 270         


Ser Gln Leu Leu Gly Asp Glu Leu Leu Leu Ala Lys Leu Pro Pro Ser 
        275                 280                 285             


Arg Glu Ser Ala Phe Arg Ser Leu Gly Pro Leu Glu Ala Gln Asp Ser 
    290                 295                 300                 


Leu Tyr Asn Ser Pro Leu Thr Glu Ser Cys Leu Ser Pro Ala Glu Glu 
305                 310                 315                 320 


Glu Pro Ala Pro Cys Lys Asp Cys Gln Pro Leu Cys Pro Pro Leu Thr 
                325                 330                 335     


Gly Ser Trp Glu Arg Gln Arg Gln Ala Ser Asp Leu Ala Ser Ser Gly 
            340                 345                 350         


Val Val Ser Leu Asp Glu Asp Glu Ala Glu Pro Glu Glu Gln 
        355                 360                 365     


<210>  5019
<211>  359
<212>  PRT
<213>  Homo Sapiens

<400>  5019

Met Pro Met Ile Ser Val Leu Gly Lys Met Phe Leu Trp Gln Arg Glu 
1               5                   10                  15      


Gly Pro Gly Gly Arg Trp Thr Cys Gln Thr Ser Arg Arg Val Ser Ser 
            20                  25                  30          


Asp Pro Ala Trp Ala Val Glu Trp Ile Glu Leu Pro Arg Gly Leu Ser 
        35                  40                  45              


Leu Ser Ser Leu Gly Ser Ala Arg Thr Leu Arg Gly Trp Ser Arg Ser 
    50                  55                  60                  


Ser Arg Pro Ser Ser Val Asp Ser Gln Asp Leu Pro Glu Val Asn Val 
65                  70                  75                  80  


Gly Asp Thr Val Ala Met Leu Pro Lys Ser Arg Arg Ala Leu Thr Ile 
                85                  90                  95      


Gln Glu Ile Ala Ala Leu Ala Arg Ser Ser Leu His Gly Ile Ser Gln 
            100                 105                 110         


Val Val Lys Asp His Val Thr Lys Pro Thr Ala Met Ala Gln Gly Arg 
        115                 120                 125             


Val Ala His Leu Ile Glu Trp Lys Gly Trp Ser Lys Pro Ser Asp Ser 
    130                 135                 140                 


Pro Ala Ala Leu Glu Ser Ala Phe Ser Ser Tyr Ser Asp Leu Ser Glu 
145                 150                 155                 160 


Gly Glu Gln Glu Ala Arg Phe Ala Ala Gly Val Ala Glu Gln Phe Ala 
                165                 170                 175     


Ile Ala Glu Ala Lys Leu Arg Ala Trp Ser Ser Val Asp Gly Glu Asp 
            180                 185                 190         


Ser Thr Asp Asp Ser Tyr Asp Glu Asp Phe Ala Gly Gly Met Asp Thr 
        195                 200                 205             


Asp Met Ala Gly Gln Leu Pro Leu Gly Pro His Leu Gln Asp Leu Phe 
    210                 215                 220                 


Thr Gly His Arg Phe Ser Arg Pro Val Arg Gln Gly Ser Val Glu Pro 
225                 230                 235                 240 


Glu Ser Asp Cys Ser Gln Thr Val Ser Pro Asp Thr Leu Cys Ser Ser 
                245                 250                 255     


Leu Cys Ser Leu Glu Asp Gly Leu Leu Gly Ser Pro Ala Arg Leu Ala 
            260                 265                 270         


Ser Gln Leu Leu Gly Asp Glu Leu Leu Leu Ala Lys Leu Pro Pro Ser 
        275                 280                 285             


Arg Glu Ser Ala Phe Arg Ser Leu Gly Pro Leu Glu Ala Gln Asp Ser 
    290                 295                 300                 


Leu Tyr Asn Ser Pro Leu Thr Glu Ser Cys Leu Ser Pro Ala Glu Glu 
305                 310                 315                 320 


Glu Pro Ala Pro Cys Lys Asp Cys Gln Pro Leu Cys Pro Pro Leu Thr 
                325                 330                 335     


Gly Ser Trp Glu Arg Gln Arg Gln Ala Ser Asp Leu Gly Leu Ala Pro 
            340                 345                 350         


Ala Leu Pro Glu Pro Met Gly 
        355                 


<210>  5020
<211>  890
<212>  PRT
<213>  Homo Sapiens

<400>  5020

Met Ser Arg Ser Ala Thr Leu Leu Leu Cys Leu Leu Gly Cys His Val 
1               5                   10                  15      


Trp Lys Ala Val Thr Lys Thr Leu Arg Glu Pro Gly Ala Gly Ala Gln 
            20                  25                  30          


Glu Val Thr Leu Lys Val His Ile Ser Asp Ala Ser Thr His Gln Pro 
        35                  40                  45              


Val Ala Asp Ala Leu Ile Glu Ile Phe Thr Asn Gln Ala Ser Ile Ala 
    50                  55                  60                  


Ser Gly Thr Ser Gly Thr Asp Gly Val Ala Phe Ile Lys Phe Gln Tyr 
65                  70                  75                  80  


Lys Leu Gly Ser Gln Leu Ile Val Thr Ala Ser Lys His Ala Tyr Val 
                85                  90                  95      


Pro Asn Ser Ala Pro Trp Lys Pro Ile Arg Leu Pro Val Phe Ser Ser 
            100                 105                 110         


Leu Ser Leu Gly Leu Leu Pro Glu Arg Ser Ala Thr Leu Met Val Tyr 
        115                 120                 125             


Glu Asp Val Val Gln Ile Val Ser Gly Phe Gln Gly Ala Arg Pro Gln 
    130                 135                 140                 


Pro Arg Val His Phe Gln Arg Arg Ala Leu Arg Leu Pro Glu Asn Thr 
145                 150                 155                 160 


Ser Tyr Ser Asp Leu Thr Ala Phe Leu Thr Ala Ala Ser Ser Pro Ser 
                165                 170                 175     


Glu Val Asp Ser Phe Pro Tyr Leu Arg Gly Leu Asp Gly Asn Gly Thr 
            180                 185                 190         


Gly Asn Ser Thr Arg His Asp Leu Thr Pro Val Thr Ala Val Ser Val 
        195                 200                 205             


His Leu Leu Ser Ser Asn Gly Thr Pro Val Leu Val Asp Gly Pro Ile 
    210                 215                 220                 


Tyr Val Thr Val Pro Leu Ala Thr Gln Ser Ser Leu Arg His Asn Ala 
225                 230                 235                 240 


Tyr Val Ala Ala Trp Arg Phe Asp Gln Lys Leu Gly Thr Trp Leu Lys 
                245                 250                 255     


Ser Gly Leu Gly Leu Val His Gln Glu Gly Ser Gln Leu Thr Trp Thr 
            260                 265                 270         


Tyr Ile Ala Pro Gln Leu Gly Tyr Trp Val Ala Ala Met Ser Pro Pro 
        275                 280                 285             


Ile Pro Gly Pro Val Val Thr Gln Asp Ile Thr Thr Tyr His Thr Val 
    290                 295                 300                 


Phe Leu Leu Ala Ile Leu Gly Gly Met Ala Phe Ile Leu Leu Val Leu 
305                 310                 315                 320 


Leu Cys Leu Leu Leu Tyr Tyr Cys Arg Arg Lys Cys Leu Lys Pro Arg 
                325                 330                 335     


Gln His His Arg Lys Leu Gln Leu Pro Ala Gly Leu Glu Ser Ser Lys 
            340                 345                 350         


Arg Asp Gln Ser Thr Ser Met Ser His Ile Asn Leu Leu Phe Ser Arg 
        355                 360                 365             


Arg Ala Ser Glu Phe Pro Gly Pro Leu Ser Val Thr Ser His Gly Arg 
    370                 375                 380                 


Pro Glu Ala Pro Gly Thr Lys Glu Leu Met Ser Gly Val His Leu Glu 
385                 390                 395                 400 


Met Met Ser Pro Gly Gly Glu Gly Asp Leu His Thr Pro Met Leu Lys 
                405                 410                 415     


Leu Ser Tyr Ser Thr Ser Gln Glu Phe Ser Ser Arg Glu Glu Leu Leu 
            420                 425                 430         


Ser Cys Lys Glu Glu Asp Lys Ser Gln Ile Ser Phe Asp Asn Leu Thr 
        435                 440                 445             


Pro Ser Gly Thr Leu Gly Lys Asp Tyr His Lys Ser Val Glu Val Phe 
    450                 455                 460                 


Pro Leu Lys Ala Arg Lys Ser Met Glu Arg Glu Gly Tyr Glu Ser Ser 
465                 470                 475                 480 


Gly Asn Asp Asp Tyr Arg Gly Ser Tyr Asn Thr Val Leu Ser Gln Pro 
                485                 490                 495     


Leu Phe Glu Lys Gln Asp Arg Glu Gly Pro Ala Ser Thr Gly Ser Lys 
            500                 505                 510         


Leu Thr Ile Gln Glu His Leu Tyr Pro Ala Pro Ser Ser Pro Glu Lys 
        515                 520                 525             


Glu Gln Leu Leu Asp Arg Arg Pro Thr Glu Cys Met Met Ser Arg Ser 
    530                 535                 540                 


Val Asp His Leu Glu Arg Pro Thr Ser Phe Pro Arg Pro Gly Gln Leu 
545                 550                 555                 560 


Ile Cys Cys Ser Ser Val Asp Gln Val Asn Asp Ser Val Tyr Arg Lys 
                565                 570                 575     


Val Leu Pro Ala Leu Val Ile Pro Ala His Tyr Met Lys Leu Pro Gly 
            580                 585                 590         


Asp His Ser Tyr Val Ser Gln Pro Leu Val Val Pro Ala Asp Gln Gln 
        595                 600                 605             


Leu Glu Ile Glu Arg Leu Gln Ala Glu Leu Ser Asn Pro His Ala Gly 
    610                 615                 620                 


Ile Phe Pro His Pro Ser Ser Gln Ile Gln Pro Gln Pro Leu Ser Ser 
625                 630                 635                 640 


Gln Ala Ile Ser Gln Gln His Leu Gln Asp Ala Gly Thr Arg Glu Trp 
                645                 650                 655     


Ser Pro Gln Asn Ala Ser Met Ser Glu Ser Leu Ser Ile Pro Ala Ser 
            660                 665                 670         


Leu Asn Asp Ala Ala Leu Ala Gln Met Asn Ser Glu Val Gln Leu Leu 
        675                 680                 685             


Thr Glu Lys Ala Leu Met Glu Leu Gly Gly Gly Lys Pro Leu Pro His 
    690                 695                 700                 


Pro Arg Ala Trp Phe Val Ser Leu Asp Gly Arg Ser Asn Ala His Val 
705                 710                 715                 720 


Arg His Ser Tyr Ile Asp Leu Gln Arg Ala Gly Arg Asn Gly Ser Asn 
                725                 730                 735     


Asp Ala Ser Leu Asp Ser Gly Val Asp Met Asn Glu Pro Lys Ser Ala 
            740                 745                 750         


Arg Lys Gly Arg Gly Asp Ala Leu Ser Leu Gln Gln Asn Tyr Pro Pro 
        755                 760                 765             


Val Gln Glu His Gln Gln Lys Glu Pro Arg Ala Pro Asp Ser Thr Ala 
    770                 775                 780                 


Tyr Thr Gln Leu Val Tyr Leu Asp Asp Val Glu Gln Ser Gly Ser Glu 
785                 790                 795                 800 


Cys Gly Thr Thr Val Cys Thr Pro Glu Asp Ser Ala Leu Arg Cys Leu 
                805                 810                 815     


Leu Glu Gly Ser Ser Arg Arg Ser Gly Gly Gln Leu Pro Ser Leu Gln 
            820                 825                 830         


Glu Glu Thr Thr Arg Arg Thr Ala Asp Ala Pro Ser Glu Pro Ala Ala 
        835                 840                 845             


Ser Pro His Gln Arg Arg Ser Ala His Glu Glu Glu Glu Asp Asp Asp 
    850                 855                 860                 


Asp Asp Asp Gln Gly Glu Asp Lys Lys Ser Pro Trp Gln Lys Arg Glu 
865                 870                 875                 880 


Glu Arg Pro Leu Met Ala Phe Asn Ile Lys 
                885                 890 


<210>  5021
<211>  198
<212>  PRT
<213>  Homo Sapiens

<400>  5021

Met Ser Arg Ser Ala Thr Leu Leu Leu Cys Leu Leu Gly Cys His Val 
1               5                   10                  15      


Trp Lys Ala Val Thr Lys Thr Leu Arg Glu Pro Gly Ala Gly Ala Gln 
            20                  25                  30          


Glu Val Thr Leu Lys Val His Ile Ser Asp Ala Ser Thr His Gln Pro 
        35                  40                  45              


Val Ala Asp Ala Leu Ile Glu Ile Phe Thr Asn Gln Ala Ser Ile Ala 
    50                  55                  60                  


Ser Gly Thr Ser Gly Thr Asp Gly Val Ala Phe Ile Lys Phe Gln Tyr 
65                  70                  75                  80  


Lys Leu Gly Ser Gln Leu Ile Val Thr Ala Ser Lys His Ala Tyr Val 
                85                  90                  95      


Pro Asn Ser Ala Pro Trp Lys Pro Ile Arg Leu Pro Val Phe Ser Ser 
            100                 105                 110         


Leu Ser Leu Gly Leu Leu Pro Glu Arg Ser Ala Thr Leu Met Val Tyr 
        115                 120                 125             


Glu Asp Val Val Gln Ile Val Ser Gly Phe Gln Gly Asn Ser Thr Arg 
    130                 135                 140                 


His Asp Leu Thr Pro Val Thr Ala Val Ser Val His Leu Leu Ser Ser 
145                 150                 155                 160 


Asn Gly Thr Pro Val Leu Val Asp Gly Pro Ile Tyr Val Thr Val Pro 
                165                 170                 175     


Leu Ala Thr Gln Ser Ser Leu Arg His Asn Ala Tyr Val Ala Ala Trp 
            180                 185                 190         


Arg Phe Asp Gln Lys Leu 
        195             


<210>  5022
<211>  826
<212>  PRT
<213>  Homo Sapiens

<400>  5022

Met Ala Arg Leu Cys Arg Arg Val Pro Cys Thr Leu Leu Leu Gly Leu 
1               5                   10                  15      


Ala Val Val Leu Leu Lys Ala Arg Leu Val Pro Ala Ala Ala Arg Ala 
            20                  25                  30          


Glu Leu Ser Arg Ser Asp Leu Ser Leu Ile Gln Gln Gln Gln Gln Gln 
        35                  40                  45              


Gln Gln Gln Gln Gln Gln Gln Gln Lys Gln Leu Glu Glu Ala Glu Glu 
    50                  55                  60                  


Glu Arg Thr Glu Val Pro Gly Ala Thr Ser Thr Leu Thr Val Pro Val 
65                  70                  75                  80  


Ser Val Phe Met Leu Lys Val Gln Val Asn Asp Ile Ile Ser Arg Gln 
                85                  90                  95      


Tyr Leu Ser Gln Ala Val Val Glu Val Phe Val Asn Tyr Thr Lys Thr 
            100                 105                 110         


Asn Ser Thr Val Thr Lys Ser Asn Gly Ala Val Leu Ile Lys Val Pro 
        115                 120                 125             


Tyr Lys Leu Gly Leu Ser Leu Thr Ile Ile Ala Tyr Lys Asp Gly Tyr 
    130                 135                 140                 


Val Leu Thr Pro Leu Pro Trp Lys Thr Arg Arg Met Pro Ile Tyr Ser 
145                 150                 155                 160 


Ser Val Thr Leu Ser Leu Phe Pro Gln Ser Gln Ala Asn Ile Trp Leu 
                165                 170                 175     


Phe Glu Asp Thr Val Leu Ile Thr Gly Lys Leu Ala Asp Ala Lys Ser 
            180                 185                 190         


Gln Pro Ser Val Gln Phe Ser Lys Ala Leu Ile Lys Leu Pro Asp Asn 
        195                 200                 205             


His His Ile Ser Asn Val Thr Gly Tyr Leu Thr Val Leu Gln Gln Phe 
    210                 215                 220                 


Leu Lys Val Asp Asn Phe Leu His Thr Thr Gly Ile Thr Leu Asn Lys 
225                 230                 235                 240 


Pro Gly Phe Glu Asn Ile Glu Leu Thr Pro Leu Ala Ala Ile Cys Val 
                245                 250                 255     


Lys Ile Tyr Ser Gly Gly Lys Glu Leu Lys Val Asn Gly Ser Ile Gln 
            260                 265                 270         


Val Ser Leu Pro Leu Leu Arg Leu Asn Asp Ile Ser Ala Gly Asp Arg 
        275                 280                 285             


Ile Pro Ala Trp Thr Phe Asp Met Asn Thr Gly Ala Trp Val Asn His 
    290                 295                 300                 


Gly Arg Gly Met Val Lys Glu His Asn Asn His Leu Ile Trp Thr Tyr 
305                 310                 315                 320 


Asp Ala Pro His Leu Gly Tyr Trp Ile Ala Ala Pro Leu Pro Gly Thr 
                325                 330                 335     


Arg Gly Ser Gly Ile Asn Glu Asp Ser Lys Asp Ile Thr Ala Tyr His 
            340                 345                 350         


Thr Val Phe Leu Thr Ala Ile Leu Gly Gly Thr Ile Val Ile Val Ile 
        355                 360                 365             


Gly Phe Phe Ala Val Leu Leu Cys Tyr Cys Arg Asp Lys Cys Gly Thr 
    370                 375                 380                 


Pro Gln Lys Arg Glu Arg Asn Ile Thr Lys Leu Glu Val Leu Lys Arg 
385                 390                 395                 400 


Asp Gln Thr Thr Ser Thr Thr His Ile Asn His Ile Ser Thr Val Lys 
                405                 410                 415     


Val Ala Leu Lys Ala Glu Asp Lys Ser Gln Leu Phe Asn Ala Lys Asn 
            420                 425                 430         


Ser Ser Tyr Ser Pro Gln Lys Lys Glu Pro Ser Lys Ala Glu Thr Glu 
        435                 440                 445             


Glu Arg Val Ser Met Val Lys Thr Arg Asp Asp Phe Lys Ile Tyr Asn 
    450                 455                 460                 


Glu Asp Val Ser Phe Leu Ser Val Asn Gln Asn Asn Tyr Ser Arg Asn 
465                 470                 475                 480 


Pro Thr Gln Ser Leu Glu Pro Asn Val Gly Ser Lys Gln Pro Lys His 
                485                 490                 495     


Ile Asn Asn Asn Leu Ser Ser Ser Leu Gly Asp Ala Gln Asp Glu Lys 
            500                 505                 510         


Arg Tyr Leu Thr Gly Asn Glu Glu Ala Tyr Gly Arg Ser His Ile Pro 
        515                 520                 525             


Glu Gln Leu Met His Ile Tyr Ser Gln Pro Ile Ala Ile Leu Gln Thr 
    530                 535                 540                 


Ser Asp Leu Phe Ser Thr Pro Glu Gln Leu His Thr Ala Lys Ser Ala 
545                 550                 555                 560 


Thr Leu Pro Arg Lys Gly Gln Leu Val Tyr Gly Gln Leu Met Glu Pro 
                565                 570                 575     


Val Asn Arg Glu Asn Phe Thr Gln Thr Leu Pro Lys Met Pro Ile His 
            580                 585                 590         


Ser His Ala Gln Pro Pro Asp Ala Arg Glu Glu Asp Ile Ile Leu Glu 
        595                 600                 605             


Gly Gln Gln Ser Leu Pro Ser Gln Ala Ser Asp Trp Ser Arg Tyr Ser 
    610                 615                 620                 


Ser Ser Leu Leu Glu Ser Val Ser Val Pro Gly Thr Leu Asn Glu Ala 
625                 630                 635                 640 


Val Val Met Thr Pro Phe Ser Ser Glu Leu Gln Gly Ile Ser Glu Gln 
                645                 650                 655     


Thr Leu Leu Glu Leu Ser Lys Gly Lys Pro Ser Pro His Pro Arg Ala 
            660                 665                 670         


Trp Phe Val Ser Leu Asp Gly Lys Pro Val Ala Gln Val Arg His Ser 
        675                 680                 685             


Phe Ile Asp Leu Lys Lys Gly Lys Arg Thr Gln Ser Asn Asp Thr Ser 
    690                 695                 700                 


Leu Asp Ser Gly Val Asp Met Asn Glu Leu His Ser Ser Arg Lys Leu 
705                 710                 715                 720 


Glu Arg Glu Lys Thr Phe Ile Lys Ser Met His Gln Pro Lys Ile Leu 
                725                 730                 735     


Tyr Leu Glu Asp Leu Asp Leu Ser Ser Ser Glu Ser Gly Thr Thr Val 
            740                 745                 750         


Cys Ser Pro Glu Asp Pro Ala Leu Arg His Ile Leu Asp Gly Gly Ser 
        755                 760                 765             


Gly Val Ile Met Glu His Pro Gly Glu Glu Ser Pro Gly Arg Lys Ser 
    770                 775                 780                 


Thr Val Glu Asp Phe Glu Ala Asn Thr Ser Pro Thr Lys Arg Arg Gly 
785                 790                 795                 800 


Arg Pro Pro Leu Ala Lys Arg Asp Ser Lys Thr Asn Ile Trp Lys Lys 
                805                 810                 815     


Arg Glu Glu Arg Pro Leu Ile Pro Ile Asn 
            820                 825     


<210>  5023
<211>  238
<212>  PRT
<213>  Homo Sapiens

<400>  5023

Met Ala Arg Leu Cys Arg Arg Val Pro Cys Thr Leu Leu Leu Gly Leu 
1               5                   10                  15      


Ala Val Val Leu Leu Lys Ala Arg Leu Val Pro Ala Ala Ala Arg Ala 
            20                  25                  30          


Glu Leu Ser Arg Ser Asp Leu Ser Leu Ile Gln Gln Gln Gln Gln Gln 
        35                  40                  45              


Gln Gln Gln Gln Gln Gln Gln Gln Lys Gln Leu Glu Glu Ala Glu Glu 
    50                  55                  60                  


Glu Arg Thr Glu Val Pro Gly Ala Thr Ser Thr Leu Thr Val Pro Val 
65                  70                  75                  80  


Ser Val Phe Met Leu Lys Val Gln Val Asn Asp Ile Ile Ser Arg Gln 
                85                  90                  95      


Tyr Leu Ser Gln Ala Val Val Glu Val Phe Val Asn Tyr Thr Lys Thr 
            100                 105                 110         


Asn Ser Thr Val Thr Lys Ser Asn Gly Ala Val Leu Ile Lys Val Pro 
        115                 120                 125             


Tyr Lys Leu Gly Leu Ser Leu Thr Ile Ile Ala Tyr Lys Asp Gly Tyr 
    130                 135                 140                 


Val Leu Thr Pro Leu Pro Trp Lys Thr Arg Arg Met Pro Ile Tyr Ser 
145                 150                 155                 160 


Ser Val Thr Leu Ser Leu Phe Pro Gln Ser Gln Ala Asn Ile Trp Leu 
                165                 170                 175     


Phe Glu Asp Thr Val Leu Ile Thr Gly Lys Leu Ala Asp Ala Lys Ser 
            180                 185                 190         


Gln Pro Ser Val Gln Phe Ser Lys Ala Leu Ile Lys Leu Pro Asp Asn 
        195                 200                 205             


His His Ile Ser Asn Val Thr Gly Tyr Leu Thr Val Leu Gln Gln Phe 
    210                 215                 220                 


Leu Lys Val Asp Asn Phe Leu His Thr Thr Gly Ile Thr Gln 
225                 230                 235             


<210>  5024
<211>  306
<212>  PRT
<213>  Homo Sapiens

<400>  5024

Met Lys Lys Asp Glu Pro Pro Leu Asp Phe Pro Asp Thr Leu Glu Gly 
1               5                   10                  15      


Phe Glu Tyr Ala Phe Asn Glu Lys Gly Gln Leu Arg His Ile Lys Thr 
            20                  25                  30          


Gly Glu Pro Phe Val Phe Asn Tyr Arg Glu Asp Leu His Arg Trp Asn 
        35                  40                  45              


Gln Lys Arg Tyr Glu Ala Leu Gly Glu Ile Ile Thr Lys Tyr Val Tyr 
    50                  55                  60                  


Glu Leu Leu Glu Lys Asp Cys Asn Leu Lys Lys Val Ser Ile Pro Glu 
65                  70                  75                  80  


Gly Tyr Gly Val Ile Val Leu Asn Pro Asn Glu Asn Tyr Ile Glu Val 
                85                  90                  95      


Glu Lys Pro Lys Ile His Val Gln Ser Ser Ser Asp Ser Ser Asp Glu 
            100                 105                 110         


Pro Ala Glu Lys Arg Glu Arg Lys Asp Lys Val Ser Lys Glu Thr Lys 
        115                 120                 125             


Lys Arg Arg Asp Phe Tyr Glu Lys Tyr Arg Asn Pro Gln Arg Glu Lys 
    130                 135                 140                 


Glu Met Met Gln Leu Tyr Ile Arg Glu Asn Gly Ser Pro Glu Glu His 
145                 150                 155                 160 


Ala Ile Tyr Val Trp Asp His Phe Ile Ala Gln Ala Ala Ala Glu Asn 
                165                 170                 175     


Val Phe Phe Val Ala His Ser Tyr Gly Gly Leu Ala Phe Val Glu Leu 
            180                 185                 190         


Met Ile Gln Arg Glu Ala Asp Val Lys Asn Lys Val Thr Ala Val Ala 
        195                 200                 205             


Leu Thr Asp Ser Val His Asn Val Trp His Gln Glu Ala Gly Lys Thr 
    210                 215                 220                 


Ile Arg Glu Trp Met Arg Glu Asn Cys Cys Asn Trp Val Ser Ser Ser 
225                 230                 235                 240 


Glu Pro Leu Asp Thr Ser Val Glu Ser Met Leu Pro Asp Cys Pro Arg 
                245                 250                 255     


Val Ser Ala Gly Thr Asp Arg His Glu Leu Thr Ser Trp Lys Ser Phe 
            260                 265                 270         


Pro Ser Ile Phe Lys Phe Phe Thr Glu Ala Ser Glu Ala Lys Thr Ser 
        275                 280                 285             


Ser Leu Lys Pro Ala Val Thr Arg Arg Ser His Arg Ile Lys His Glu 
    290                 295                 300                 


Glu Leu 
305     


<210>  5025
<211>  370
<212>  PRT
<213>  Homo Sapiens

<400>  5025

Met Lys Lys Asp Glu Pro Pro Leu Asp Phe Pro Asp Thr Leu Glu Gly 
1               5                   10                  15      


Phe Glu Tyr Ala Phe Asn Glu Lys Gly Gln Leu Arg His Ile Lys Thr 
            20                  25                  30          


Gly Glu Pro Phe Val Phe Asn Tyr Arg Glu Asp Leu His Arg Trp Asn 
        35                  40                  45              


Gln Lys Arg Tyr Glu Ala Leu Gly Glu Ile Ile Thr Lys Tyr Val Tyr 
    50                  55                  60                  


Glu Leu Leu Glu Lys Asp Cys Asn Leu Lys Lys Val Ser Ile Pro Val 
65                  70                  75                  80  


Asp Ala Thr Glu Ser Glu Pro Lys Ser Phe Ile Phe Met Ser Glu Asp 
                85                  90                  95      


Ala Leu Thr Asn Pro Gln Lys Leu Met Val Leu Ile His Gly Ser Gly 
            100                 105                 110         


Val Val Arg Ala Gly Gln Trp Ala Arg Arg Leu Ile Ile Asn Glu Asp 
        115                 120                 125             


Leu Asp Ser Gly Thr Gln Ile Pro Phe Ile Lys Arg Ala Val Ala Glu 
    130                 135                 140                 


Gly Tyr Gly Val Ile Val Leu Asn Pro Asn Glu Asn Tyr Ile Glu Val 
145                 150                 155                 160 


Glu Lys Pro Lys Ile His Val Gln Ser Ser Ser Asp Ser Ser Asp Glu 
                165                 170                 175     


Pro Ala Glu Lys Arg Glu Arg Lys Asp Lys Val Ser Lys Glu Thr Lys 
            180                 185                 190         


Lys Arg Arg Asp Phe Tyr Glu Lys Tyr Arg Asn Pro Gln Arg Glu Lys 
        195                 200                 205             


Glu Met Met Gln Leu Tyr Ile Arg Glu Asn Gly Ser Pro Glu Glu His 
    210                 215                 220                 


Ala Ile Tyr Val Trp Asp His Phe Ile Ala Gln Ala Ala Ala Glu Asn 
225                 230                 235                 240 


Val Phe Phe Val Ala His Ser Tyr Gly Gly Leu Ala Phe Val Glu Leu 
                245                 250                 255     


Met Ile Gln Arg Glu Ala Asp Val Lys Asn Lys Val Thr Ala Val Ala 
            260                 265                 270         


Leu Thr Asp Ser Val His Asn Val Trp His Gln Glu Ala Gly Lys Thr 
        275                 280                 285             


Ile Arg Glu Trp Met Arg Glu Asn Cys Cys Asn Trp Val Ser Ser Ser 
    290                 295                 300                 


Glu Pro Leu Asp Thr Ser Val Glu Ser Met Leu Pro Asp Cys Pro Arg 
305                 310                 315                 320 


Val Ser Ala Gly Thr Asp Arg His Glu Leu Thr Ser Trp Lys Ser Phe 
                325                 330                 335     


Pro Ser Ile Phe Lys Phe Phe Thr Glu Ala Ser Glu Ala Lys Thr Ser 
            340                 345                 350         


Ser Leu Lys Pro Ala Val Thr Arg Arg Ser His Arg Ile Lys His Glu 
        355                 360                 365             


Glu Leu 
    370 


<210>  5026
<211>  269
<212>  PRT
<213>  Homo Sapiens

<400>  5026

Met Asn Arg Leu Leu Ile Phe Leu Ile Pro Trp Lys Asp Leu Asn Met 
1               5                   10                  15      


Leu Leu Met Lys Ile Ile Thr Lys Tyr Val Tyr Glu Leu Leu Glu Lys 
            20                  25                  30          


Asp Cys Asn Leu Lys Lys Val Ser Ile Pro Glu Gly Tyr Gly Val Ile 
        35                  40                  45              


Val Leu Asn Pro Asn Glu Asn Tyr Ile Glu Val Glu Lys Pro Lys Ile 
    50                  55                  60                  


His Val Gln Ser Ser Ser Asp Ser Ser Asp Glu Pro Ala Glu Lys Arg 
65                  70                  75                  80  


Glu Arg Lys Asp Lys Val Ser Lys Glu Thr Lys Lys Arg Arg Asp Phe 
                85                  90                  95      


Tyr Glu Lys Tyr Arg Asn Pro Gln Arg Glu Lys Glu Met Met Gln Leu 
            100                 105                 110         


Tyr Ile Arg Glu Asn Gly Ser Pro Glu Glu His Ala Ile Tyr Val Trp 
        115                 120                 125             


Asp His Phe Ile Ala Gln Ala Ala Ala Glu Asn Val Phe Phe Val Ala 
    130                 135                 140                 


His Ser Tyr Gly Gly Leu Ala Phe Val Glu Leu Met Ile Gln Arg Glu 
145                 150                 155                 160 


Ala Asp Val Lys Asn Lys Val Thr Ala Val Ala Leu Thr Asp Ser Val 
                165                 170                 175     


His Asn Val Trp His Gln Glu Ala Gly Lys Thr Ile Arg Glu Trp Met 
            180                 185                 190         


Arg Glu Asn Cys Cys Asn Trp Val Ser Ser Ser Glu Pro Leu Asp Thr 
        195                 200                 205             


Ser Val Glu Ser Met Leu Pro Asp Cys Pro Arg Val Ser Ala Gly Thr 
    210                 215                 220                 


Asp Arg His Glu Leu Thr Ser Trp Lys Ser Phe Pro Ser Ile Phe Lys 
225                 230                 235                 240 


Phe Phe Thr Glu Ala Ser Glu Ala Lys Thr Ser Ser Leu Lys Pro Ala 
                245                 250                 255     


Val Thr Arg Arg Ser His Arg Ile Lys His Glu Glu Leu 
            260                 265                 


<210>  5027
<211>  305
<212>  PRT
<213>  Homo Sapiens

<400>  5027

Met Asn Arg Leu Leu Ile Phe Leu Ile Pro Trp Lys Asp Leu Asn Met 
1               5                   10                  15      


Leu Leu Met Lys Ile Ile Thr Lys Tyr Val Tyr Glu Leu Leu Glu Lys 
            20                  25                  30          


Asp Cys Asn Leu Lys Lys Val Ser Ile Pro Val Asp Ala Thr Glu Ser 
        35                  40                  45              


Glu Pro Lys Ser Phe Ile Phe Met Ser Glu Asp Ala Leu Thr Asn Pro 
    50                  55                  60                  


Gln Lys Leu Met Val Leu Ile His Gly Ser Gly Val Val Arg Ala Gly 
65                  70                  75                  80  


Gln Trp Ala Arg Arg Leu Ile Ile Asn Glu Asp Leu Asp Ser Gly Thr 
                85                  90                  95      


Gln Ile Pro Phe Ile Lys Arg Ala Val Ala Glu Gly Tyr Gly Val Ile 
            100                 105                 110         


Val Leu Asn Pro Asn Glu Asn Tyr Ile Glu Val Glu Lys Pro Lys Ile 
        115                 120                 125             


His Val Gln Ser Ser Ser Asp Ser Ser Asp Glu Pro Ala Glu Lys Arg 
    130                 135                 140                 


Glu Arg Lys Asp Lys Val Ser Lys Glu Thr Lys Lys Arg Arg Asp Phe 
145                 150                 155                 160 


Tyr Glu Lys Tyr Arg Asn Pro Gln Arg Glu Lys Glu Met Met Gln Leu 
                165                 170                 175     


Tyr Ile Arg Glu Asn Gly Ser Pro Glu Glu His Ala Ile Tyr Val Trp 
            180                 185                 190         


Asp His Phe Ile Ala Gln Ala Ala Ala Glu Asn Val Phe Phe Val Ala 
        195                 200                 205             


His Ser Tyr Gly Gly Leu Ala Phe Val Glu Leu Met Ile Gln Arg Glu 
    210                 215                 220                 


Ala Asp Val Lys Asn Lys Val Thr Ala Val Ala Leu Thr Asp Ser Val 
225                 230                 235                 240 


His Asn Val Trp His Gln Glu Ala Gly Lys Thr Ile Arg Glu Trp Met 
                245                 250                 255     


Arg Glu Asn Cys Cys Asn Trp Val Ser Ser Ser Glu Pro Leu Asp Thr 
            260                 265                 270         


Ser Val Glu Ser Met Leu Pro Asp Cys Pro Arg Val Ser Ala Gly Phe 
        275                 280                 285             


Ser Cys Cys Gln Met Gln Ser His Glu Asp Leu Leu Leu Cys Phe Leu 
    290                 295                 300                 


Leu 
305 


<210>  5028
<211>  416
<212>  PRT
<213>  Homo Sapiens

<400>  5028

Met Ser Ile Ser Leu Ser Ser Leu Ile Leu Leu Pro Ile Trp Ile Asn 
1               5                   10                  15      


Met Ala Gln Ile Gln Gln Gly Gly Pro Asp Glu Lys Glu Lys Thr Thr 
            20                  25                  30          


Ala Leu Lys Asp Leu Leu Ser Arg Ile Asp Leu Asp Glu Leu Met Lys 
        35                  40                  45              


Lys Asp Glu Pro Pro Leu Asp Phe Pro Asp Thr Leu Glu Gly Phe Glu 
    50                  55                  60                  


Tyr Ala Phe Asn Glu Lys Gly Gln Leu Arg His Ile Lys Thr Gly Glu 
65                  70                  75                  80  


Pro Phe Val Phe Asn Tyr Arg Glu Asp Leu His Arg Trp Asn Gln Lys 
                85                  90                  95      


Arg Tyr Glu Ala Leu Gly Glu Ile Ile Thr Lys Tyr Val Tyr Glu Leu 
            100                 105                 110         


Leu Glu Lys Asp Cys Asn Leu Lys Lys Val Ser Ile Pro Val Asp Ala 
        115                 120                 125             


Thr Glu Ser Glu Pro Lys Ser Phe Ile Phe Met Ser Glu Asp Ala Leu 
    130                 135                 140                 


Thr Asn Pro Gln Lys Leu Met Val Leu Ile His Gly Ser Gly Val Val 
145                 150                 155                 160 


Arg Ala Gly Gln Trp Ala Arg Arg Leu Ile Ile Asn Glu Asp Leu Asp 
                165                 170                 175     


Ser Gly Thr Gln Ile Pro Phe Ile Lys Arg Ala Val Ala Glu Gly Tyr 
            180                 185                 190         


Gly Val Ile Val Leu Asn Pro Asn Glu Asn Tyr Ile Glu Val Glu Lys 
        195                 200                 205             


Pro Lys Ile His Val Gln Ser Ser Ser Asp Ser Ser Asp Glu Pro Ala 
    210                 215                 220                 


Glu Lys Arg Glu Arg Lys Asp Lys Val Ser Lys Glu Thr Lys Lys Arg 
225                 230                 235                 240 


Arg Asp Phe Tyr Glu Lys Tyr Arg Asn Pro Gln Arg Glu Lys Glu Met 
                245                 250                 255     


Met Gln Leu Tyr Ile Arg Glu Asn Gly Ser Pro Glu Glu His Ala Ile 
            260                 265                 270         


Tyr Val Trp Asp His Phe Ile Ala Gln Ala Ala Ala Glu Asn Val Phe 
        275                 280                 285             


Phe Val Ala His Ser Tyr Gly Gly Leu Ala Phe Val Glu Leu Met Ile 
    290                 295                 300                 


Gln Arg Glu Ala Asp Val Lys Asn Lys Val Thr Ala Val Ala Leu Thr 
305                 310                 315                 320 


Asp Ser Val His Asn Val Trp His Gln Glu Ala Gly Lys Thr Ile Arg 
                325                 330                 335     


Glu Trp Met Arg Glu Asn Cys Cys Asn Trp Val Ser Ser Ser Glu Pro 
            340                 345                 350         


Leu Asp Thr Ser Val Glu Ser Met Leu Pro Asp Cys Pro Arg Val Ser 
        355                 360                 365             


Ala Gly Thr Asp Arg His Glu Leu Thr Ser Trp Lys Ser Phe Pro Ser 
    370                 375                 380                 


Ile Phe Lys Phe Phe Thr Glu Ala Ser Glu Ala Lys Thr Ser Ser Leu 
385                 390                 395                 400 


Lys Pro Ala Val Thr Arg Arg Ser His Arg Ile Lys His Glu Glu Leu 
                405                 410                 415     


<210>  5029
<211>  36
<212>  PRT
<213>  Homo Sapiens

<400>  5029

Ala Ala Ala Ala Ala Phe Gly Glu Ser Ala Gly Gln Val Gly Gly Ala 
1               5                   10                  15      


Ala Glu Ala Asp Val Arg Gly Ala Glu Pro Pro Pro Cys Leu Leu Arg 
            20                  25                  30          


Gly Pro Leu Phe 
        35      


<210>  5030
<211>  76
<212>  PRT
<213>  Homo Sapiens

<400>  5030

Met Asp Gln Glu Pro Val Gly Gly Val Glu Arg Gly Glu Ala Val Ala 
1               5                   10                  15      


Ala Ser Gly Ala Ala Ala Ala Ala Ala Phe Gly Glu Ser Ala Gly Gln 
            20                  25                  30          


Met Ser Asn Glu Arg Gly Phe Glu Asn Val Glu Leu Gly Val Ile Gly 
        35                  40                  45              


Lys Lys Lys Lys Val Pro Arg Arg Val Ile His Phe Val Ser Gly Glu 
    50                  55                  60                  


Thr Met Glu Glu Tyr Ser Thr Asp Glu Asp Glu Val 
65                  70                  75      


<210>  5031
<211>  213
<212>  PRT
<213>  Homo Sapiens

<400>  5031

Met Asp Gln Glu Pro Val Gly Gly Val Glu Arg Gly Glu Ala Val Ala 
1               5                   10                  15      


Ala Ser Gly Ala Ala Ala Ala Ala Ala Phe Gly Glu Ser Ala Gly Gln 
            20                  25                  30          


Met Ser Asn Glu Arg Gly Phe Glu Asn Val Glu Leu Gly Val Ile Gly 
        35                  40                  45              


Lys Lys Lys Lys Val Pro Arg Arg Val Ile His Phe Val Ser Gly Glu 
    50                  55                  60                  


Thr Met Glu Glu Tyr Ser Thr Asp Glu Asp Glu Val Asp Gly Leu Glu 
65                  70                  75                  80  


Lys Lys Asp Val Leu Pro Thr Val Asp Pro Thr Lys Leu Thr Trp Gly 
                85                  90                  95      


Pro Tyr Leu Trp Phe Tyr Met Leu Arg Ala Ala Thr Ser Thr Leu Ser 
            100                 105                 110         


Val Cys Asp Phe Leu Gly Glu Lys Ile Ala Ser Val Leu Gly Ile Ser 
        115                 120                 125             


Thr Pro Lys Tyr Gln Tyr Ala Ile Asp Glu Tyr Tyr Arg Met Lys Lys 
    130                 135                 140                 


Glu Glu Glu Glu Glu Glu Glu Glu Asn Arg Met Ser Glu Glu Ala Glu 
145                 150                 155                 160 


Lys Gln Tyr Gln Gln Asn Lys Leu Gln Thr Asp Ser Ile Val Gln Thr 
                165                 170                 175     


Asp Gln Pro Glu Thr Val Ile Ser Ser Ser Phe Val Asn Val Asn Phe 
            180                 185                 190         


Glu Met Glu Gly Asp Ser Glu Val Ile Met Glu Ser Lys Gln Asn Pro 
        195                 200                 205             


Val Ser Val Pro Pro 
    210             


<210>  5032
<211>  213
<212>  PRT
<213>  Homo Sapiens

<400>  5032

Met Asp Gln Glu Pro Val Gly Gly Val Glu Arg Gly Glu Ala Val Ala 
1               5                   10                  15      


Ala Ser Gly Ala Ala Ala Ala Ala Ala Phe Gly Glu Ser Ala Gly Gln 
            20                  25                  30          


Met Ser Asn Glu Arg Gly Phe Glu Asn Val Glu Leu Gly Val Ile Gly 
        35                  40                  45              


Lys Lys Lys Lys Val Pro Arg Arg Val Ile His Phe Val Ser Gly Glu 
    50                  55                  60                  


Thr Met Glu Glu Tyr Ser Thr Asp Glu Asp Glu Val Asp Gly Leu Glu 
65                  70                  75                  80  


Lys Lys Asp Val Leu Pro Thr Val Asp Pro Thr Lys Leu Thr Trp Gly 
                85                  90                  95      


Pro Tyr Leu Trp Phe Tyr Met Leu Arg Ala Ala Thr Ser Thr Leu Ser 
            100                 105                 110         


Val Cys Asp Phe Leu Gly Glu Lys Ile Ala Ser Val Leu Gly Ile Ser 
        115                 120                 125             


Thr Pro Lys Tyr Gln Tyr Ala Ile Asp Glu Tyr Tyr Arg Met Lys Lys 
    130                 135                 140                 


Glu Glu Glu Glu Glu Glu Glu Glu Asn Arg Met Ser Glu Glu Ala Glu 
145                 150                 155                 160 


Lys Gln Tyr Gln Gln Asn Lys Leu Gln Thr Asp Ser Ile Val Gln Thr 
                165                 170                 175     


Asp Gln Pro Glu Thr Val Ile Ser Ser Ser Phe Val Asn Val Asn Phe 
            180                 185                 190         


Glu Met Glu Gly Asp Ser Glu Val Ile Met Glu Ser Lys Gln Asn Pro 
        195                 200                 205             


Val Ser Val Pro Pro 
    210             


<210>  5033
<211>  236
<212>  PRT
<213>  Homo Sapiens

<400>  5033

Met Glu Val Gly Leu Pro Ala Ile Thr Leu Phe Leu Thr Ser Ala Ser 
1               5                   10                  15      


Ser Pro Val Val Ala Thr Thr Met Asp Gln Glu Pro Val Gly Gly Val 
            20                  25                  30          


Glu Arg Gly Glu Ala Val Ala Ala Ser Gly Ala Ala Ala Ala Ala Ala 
        35                  40                  45              


Phe Gly Glu Ser Ala Gly Gln Met Ser Asn Glu Arg Gly Phe Glu Asn 
    50                  55                  60                  


Val Glu Leu Gly Val Ile Gly Lys Lys Lys Lys Val Pro Arg Arg Val 
65                  70                  75                  80  


Ile His Phe Val Ser Gly Glu Thr Met Glu Glu Tyr Ser Thr Asp Glu 
                85                  90                  95      


Asp Glu Val Asp Gly Leu Glu Lys Lys Asp Val Leu Pro Thr Val Asp 
            100                 105                 110         


Pro Thr Lys Leu Thr Trp Gly Pro Tyr Leu Trp Phe Tyr Met Leu Arg 
        115                 120                 125             


Ala Ala Thr Ser Thr Leu Ser Val Cys Asp Phe Leu Gly Glu Lys Ile 
    130                 135                 140                 


Ala Ser Val Leu Gly Ile Ser Thr Pro Lys Tyr Gln Tyr Ala Ile Asp 
145                 150                 155                 160 


Glu Tyr Tyr Arg Met Lys Lys Glu Glu Glu Glu Glu Glu Glu Glu Asn 
                165                 170                 175     


Arg Met Ser Glu Glu Ala Glu Lys Gln Tyr Gln Gln Asn Lys Leu Gln 
            180                 185                 190         


Thr Asp Ser Ile Val Gln Thr Asp Gln Pro Glu Thr Val Ile Ser Ser 
        195                 200                 205             


Ser Phe Val Asn Val Asn Phe Glu Met Glu Gly Asp Ser Glu Val Ile 
    210                 215                 220                 


Met Glu Ser Lys Gln Asn Pro Val Ser Val Pro Pro 
225                 230                 235     


<210>  5034
<211>  89
<212>  PRT
<213>  Homo Sapiens

<400>  5034

Met Glu Val Gly Leu Pro Ala Ile Thr Leu Phe Leu Thr Ser Ala Ser 
1               5                   10                  15      


Ser Pro Val Val Ala Thr Thr Met Asp Gln Glu Pro Val Gly Gly Val 
            20                  25                  30          


Glu Arg Gly Glu Ala Val Ala Ala Ser Gly Ala Ala Ala Ala Ala Ala 
        35                  40                  45              


Phe Gly Glu Ser Ala Gly Gln Asn Leu Thr Leu Leu Pro Arg Leu Lys 
    50                  55                  60                  


Phe Met Ala Arg Ser Arg Leu Ala Ala Thr Ser Thr Ser Arg Val Gln 
65                  70                  75                  80  


Ala Ile Leu Leu Pro Gln Pro Pro Val 
                85                  


<210>  5035
<211>  140
<212>  PRT
<213>  Homo Sapiens

<400>  5035

Met Ser Asn Glu Arg Gly Phe Glu Asn Val Glu Leu Gly Val Ile Gly 
1               5                   10                  15      


Lys Lys Lys Lys Val Pro Arg Arg Val Ile His Phe Val Ser Gly Glu 
            20                  25                  30          


Thr Met Glu Glu Tyr Ser Thr Asp Glu Asp Glu Val Asp Gly Leu Glu 
        35                  40                  45              


Lys Lys Asp Val Leu Pro Thr Val Asp Pro Thr Lys Leu Thr Trp Gly 
    50                  55                  60                  


Pro Tyr Leu Trp Phe Tyr Met Leu Arg Ala Ala Thr Ser Thr Leu Ser 
65                  70                  75                  80  


Val Cys Asp Phe Leu Gly Glu Lys Ile Ala Ser Val Leu Gly Ile Ser 
                85                  90                  95      


Thr Pro Lys Tyr Gln Tyr Ala Ile Asp Glu Tyr Tyr Arg Met Lys Lys 
            100                 105                 110         


Glu Glu Glu Glu Glu Glu Glu Glu Asn Arg Met Ser Glu Glu Ala Glu 
        115                 120                 125             


Lys Gln Tyr Gln Gln Asn Lys Leu Gln Thr Asp Ser 
    130                 135                 140 


<210>  5036
<211>  39
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5036

Xaa Ala Phe Gly Glu Ser Ala Gly Gln Glu Ile Lys Gly Ser Lys Lys 
1               5                   10                  15      


Leu Ser His Gly Pro Lys Gly Asn Val Asp Val Arg Thr Ala Ile Ala 
            20                  25                  30          


Lys Phe Tyr Leu Lys Asp Glu 
        35                  


<210>  5037
<211>  7
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5037

Xaa Leu Arg Gly Pro Leu Phe 
1               5           


<210>  5038
<211>  49
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5038

Xaa Asn Lys Leu Gln Thr Asp Ser Ile Val Gln Thr Asp Gln Pro Glu 
1               5                   10                  15      


Thr Val Ile Ser Ser Ser Phe Val Asn Val Asn Phe Glu Met Glu Gly 
            20                  25                  30          


Asp Ser Glu Val Ile Met Glu Ser Lys Gln Asn Pro Val Ser Val Pro 
        35                  40                  45              


Pro 
    


<210>  5039
<211>  173
<212>  PRT
<213>  Homo Sapiens

<400>  5039

Met His Trp Lys Met Leu Leu Leu Leu Leu Leu Tyr Tyr Asn Ala Glu 
1               5                   10                  15      


Ala Ser Met Cys His Arg Trp Ser Arg Ala Val Leu Phe Pro Ala Ala 
            20                  25                  30          


His Arg Pro Lys Arg Ser Ser Ser Leu Pro Leu Asn Pro Val Leu Gln 
        35                  40                  45              


Thr Ser Leu Glu Glu Val Glu Leu Leu Tyr Glu Phe Leu Leu Ala Glu 
    50                  55                  60                  


Leu Glu Ile Ser Pro Asp Leu Gln Ile Ser Ile Lys Asp Glu Glu Leu 
65                  70                  75                  80  


Ala Ser Leu Arg Lys Ala Ser Asp Phe Arg Thr Val Cys Asn Asn Val 
                85                  90                  95      


Ile Pro Lys Ser Ile Pro Asp Ile Arg Arg Leu Ser Ala Ser Leu Ser 
            100                 105                 110         


Ser His Pro Gly Ile Leu Lys Lys Glu Asp Phe Glu Arg Thr Val Leu 
        115                 120                 125             


Thr Leu Ala Tyr Thr Ala Tyr Arg Thr Ala Leu Ser His Gly His Gln 
    130                 135                 140                 


Lys Asp Ile Trp Ala Gln Ser Leu Val Ser Leu Phe Gln Ala Leu Arg 
145                 150                 155                 160 


His Asp Leu Met Arg Ser Ser Gln Pro Gly Val Pro Pro 
                165                 170             


<210>  5040
<211>  173
<212>  PRT
<213>  Homo Sapiens

<400>  5040

Met His Trp Lys Met Leu Leu Leu Leu Leu Leu Tyr Tyr Asn Ala Glu 
1               5                   10                  15      


Ala Ser Met Cys His Arg Trp Ser Arg Ala Val Leu Phe Pro Ala Ala 
            20                  25                  30          


His Arg Pro Lys Arg Ser Ser Ser Leu Pro Leu Asn Pro Val Leu Gln 
        35                  40                  45              


Thr Ser Leu Glu Glu Val Glu Leu Leu Tyr Glu Phe Leu Leu Ala Glu 
    50                  55                  60                  


Leu Glu Ile Ser Pro Asp Leu Gln Ile Ser Ile Lys Asp Glu Glu Leu 
65                  70                  75                  80  


Ala Ser Leu Arg Lys Ala Ser Asp Phe Arg Thr Val Cys Asn Asn Val 
                85                  90                  95      


Ile Pro Lys Ser Ile Pro Asp Ile Arg Arg Leu Ser Ala Ser Leu Ser 
            100                 105                 110         


Ser His Pro Gly Ile Leu Lys Lys Glu Asp Phe Glu Arg Thr Val Leu 
        115                 120                 125             


Thr Leu Ala Tyr Thr Ala Tyr Arg Thr Ala Leu Ser His Gly His Gln 
    130                 135                 140                 


Lys Asp Ile Trp Ala Gln Ser Leu Val Ser Leu Phe Gln Ala Leu Arg 
145                 150                 155                 160 


His Asp Leu Met Arg Ser Ser Gln Pro Gly Val Pro Pro 
                165                 170             


<210>  5041
<211>  173
<212>  PRT
<213>  Homo Sapiens

<400>  5041

Met His Trp Lys Met Leu Leu Leu Leu Leu Leu Tyr Tyr Asn Ala Glu 
1               5                   10                  15      


Ala Ser Met Cys His Arg Trp Ser Arg Ala Val Leu Phe Pro Ala Ala 
            20                  25                  30          


His Arg Pro Lys Arg Ser Ser Ser Leu Pro Leu Asn Pro Val Leu Gln 
        35                  40                  45              


Thr Ser Leu Glu Glu Val Glu Leu Leu Tyr Glu Phe Leu Leu Ala Glu 
    50                  55                  60                  


Leu Glu Ile Ser Pro Asp Leu Gln Ile Ser Ile Lys Asp Glu Glu Leu 
65                  70                  75                  80  


Ala Ser Leu Arg Lys Ala Ser Asp Phe Arg Thr Val Cys Asn Asn Val 
                85                  90                  95      


Ile Pro Lys Ser Ile Pro Asp Ile Arg Arg Leu Ser Ala Ser Leu Ser 
            100                 105                 110         


Ser His Pro Gly Ile Leu Lys Lys Glu Asp Phe Glu Arg Thr Val Leu 
        115                 120                 125             


Thr Leu Ala Tyr Thr Ala Tyr Arg Thr Ala Leu Ser His Gly His Gln 
    130                 135                 140                 


Lys Asp Ile Trp Ala Gln Ser Leu Val Ser Leu Phe Gln Ala Leu Arg 
145                 150                 155                 160 


His Asp Leu Met Arg Ser Ser Gln Pro Gly Val Pro Pro 
                165                 170             


<210>  5042
<211>  78
<212>  PRT
<213>  Homo Sapiens

<400>  5042

Met Leu Leu Ser Ala Val Cys Val Met Leu Asn Leu Ala Gly Ser Ile 
1               5                   10                  15      


Leu Ser Cys Gln Asn Ala Gln Leu Val Asn Ser Leu Glu Gly Cys Gln 
            20                  25                  30          


Leu Ile Lys Phe Asp Ser Val Glu Val Cys Val Cys Cys Glu Leu Gln 
        35                  40                  45              


His Gln Ser Ser Gly Cys Ser Asn Leu Gly Glu Thr Leu Lys Leu Asn 
    50                  55                  60                  


Pro Leu Gln Glu Asn Cys Asn Ala Val Arg Leu Thr Leu Lys 
65                  70                  75              


<210>  5043
<211>  539
<212>  PRT
<213>  Homo Sapiens

<400>  5043

Met Pro Pro Ala Gly Gly Pro Arg Ala Pro Arg Pro Ala Ala Leu Pro 
1               5                   10                  15      


Arg Ser Leu Ser Arg Leu Arg Glu Cys Pro Gly Arg Ser Arg Ile Val 
            20                  25                  30          


Leu Ala Leu Gly Ala Thr Gln Met Ala Leu Gly Cys Leu Ile Val Ala 
        35                  40                  45              


Val Ser Phe Ala Ala Leu Ala Leu Thr Thr Ser Ala Arg Val Arg His 
    50                  55                  60                  


Ser Cys Pro Phe Trp Ala Gly Phe Ser Val Leu Leu Ser Gly Leu Ile 
65                  70                  75                  80  


Gly Val Val Ser Trp Lys Arg Pro Leu Ser Leu Val Ile Thr Phe Phe 
                85                  90                  95      


Met Leu Leu Ser Ala Val Cys Val Met Leu Asn Leu Ala Gly Ser Ile 
            100                 105                 110         


Leu Ser Cys Gln Asn Ala Gln Leu Val Asn Ser Leu Glu Gly Cys Gln 
        115                 120                 125             


Leu Ile Lys Phe Asp Ser Val Glu Val Cys Val Cys Cys Glu Leu Gln 
    130                 135                 140                 


His Gln Ser Ser Gly Cys Ser Asn Leu Gly Glu Thr Leu Lys Leu Asn 
145                 150                 155                 160 


Pro Leu Gln Glu Asn Cys Asn Ala Val Arg Leu Thr Leu Lys Asp Leu 
                165                 170                 175     


Leu Phe Ser Val Cys Ala Leu Asn Val Leu Ser Thr Ile Val Cys Ala 
            180                 185                 190         


Leu Ala Thr Ala Met Cys Cys Met Gln Met Val Ser Ser Asp Val Leu 
        195                 200                 205             


Gln Met Phe Leu Pro Gln Arg Ser His Pro Ala Asn Pro Thr Cys Val 
    210                 215                 220                 


Thr Pro His Gly Thr Val Leu His Gln Thr Leu Asp Phe Asp Glu Phe 
225                 230                 235                 240 


Ile Pro Pro Leu Pro Pro Pro Pro Tyr Tyr Pro Pro Glu Tyr Thr Cys 
                245                 250                 255     


Thr Pro Ser Thr Glu Ala Gln Arg Gly Leu His Leu Asp Phe Ala Pro 
            260                 265                 270         


Ser Pro Phe Gly Thr Leu Tyr Asp Val Ala Ile Asn Ser Pro Gly Leu 
        275                 280                 285             


Leu Tyr Pro Ala Glu Leu Pro Pro Pro Tyr Glu Ala Val Val Gly Gln 
    290                 295                 300                 


Pro Pro Ala Ser Gln Val Thr Ser Ile Gly Gln Gln Val Ala Glu Ser 
305                 310                 315                 320 


Ser Ser Gly Asp Pro Asn Thr Ser Ala Gly Phe Ser Thr Pro Val Pro 
                325                 330                 335     


Ala Asp Ser Thr Ser Leu Leu Val Ser Glu Gly Thr Ala Thr Pro Gly 
            340                 345                 350         


Ser Ser Pro Ser Pro Asp Gly Pro Val Gly Ala Pro Ala Pro Ser Glu 
        355                 360                 365             


Pro Ala Leu Pro Pro Gly His Val Ser Pro Glu Asp Pro Gly Met Gly 
    370                 375                 380                 


Ser Gln Val Gln Pro Gly Pro Gly Arg Val Ser Arg Ser Thr Ser Asp 
385                 390                 395                 400 


Pro Thr Leu Cys Thr Ser Ser Met Ala Gly Asp Ala Ser Ser His Arg 
                405                 410                 415     


Pro Ser Cys Ser Gln Asp Leu Glu Ala Gly Leu Ser Glu Ala Val Pro 
            420                 425                 430         


Gly Ser Ala Ser Met Ser Arg Ser Ala Thr Ala Ala Cys Arg Ala Gln 
        435                 440                 445             


Leu Ser Pro Ala Gly Asp Pro Asp Thr Trp Lys Thr Asp Gln Arg Pro 
    450                 455                 460                 


Thr Pro Glu Pro Phe Pro Ala Thr Ser Lys Glu Arg Pro Arg Ser Leu 
465                 470                 475                 480 


Val Asp Ser Lys Ala Tyr Ala Asp Ala Arg Val Leu Val Ala Lys Phe 
                485                 490                 495     


Leu Glu His Ser His Cys Ala Leu Pro Thr Glu Ala Gln His Met Val 
            500                 505                 510         


Gly Ala Met Arg Leu Ala Val Thr Asn Glu Glu Arg Leu Glu Glu Glu 
        515                 520                 525             


Ala Val Phe Gly Ala Asp Val Leu Asp Gln Val 
    530                 535                 


<210>  5044
<211>  575
<212>  PRT
<213>  Homo Sapiens

<400>  5044

Met Ala Ser Trp Leu Arg Arg Lys Leu Arg Gly Lys Arg Arg Pro Val 
1               5                   10                  15      


Ile Ala Phe Cys Leu Leu Met Ile Leu Ser Ala Met Ala Val Thr Arg 
            20                  25                  30          


Phe Pro Pro Gln Arg Pro Ser Ala Gly Pro Asp Pro Gly Pro Met Glu 
        35                  40                  45              


Pro Gln Gly Val Thr Gly Ala Pro Ala Thr His Ile Arg Gln Ala Leu 
    50                  55                  60                  


Ser Ser Ser Arg Arg Gln Arg Ala Arg Asn Met Gly Phe Trp Arg Ser 
65                  70                  75                  80  


Arg Ala Leu Pro Arg Asn Ser Ile Leu Val Cys Ala Glu Glu Gln Gly 
                85                  90                  95      


His Arg Ala Arg Val Asp Arg Ser Arg Glu Ser Pro Gly Gly Asp Leu 
            100                 105                 110         


Arg His Pro Gly Arg Val Arg Arg Asp Ile Thr Leu Ser Gly His Pro 
        115                 120                 125             


Arg Leu Ser Thr Gln His Val Val Leu Leu Arg Glu Asp Glu Val Gly 
    130                 135                 140                 


Asp Pro Gly Thr Lys Asp Leu Gly His Pro Gln His Gly Ser Pro Ile 
145                 150                 155                 160 


Gln Glu Thr Gln Ser Glu Val Val Thr Leu Val Ser Pro Leu Pro Gly 
                165                 170                 175     


Ser Asp Met Ala Ala Leu Pro Ala Trp Arg Ala Thr Ser Gly Leu Thr 
            180                 185                 190         


Leu Trp Pro His Thr Ala Glu Gly Arg Asp Leu Leu Gly Ala Glu Asn 
        195                 200                 205             


Arg Ala Leu Thr Gly Gly Gln Gln Ala Glu Asp Pro Thr Leu Ala Ser 
    210                 215                 220                 


Gly Ala His Gln Trp Pro Gly Ser Val Glu Lys Leu Gln Gly Ser Val 
225                 230                 235                 240 


Trp Cys Asp Ala Glu Thr Leu Leu Ser Ser Ser Arg Thr Gly Gly Gln 
                245                 250                 255     


Ala Pro Pro Trp Leu Thr Asp His Asp Val Gln Met Leu Arg Leu Leu 
            260                 265                 270         


Ala Gln Gly Glu Val Val Asp Lys Ala Arg Val Pro Ala His Gly Gln 
        275                 280                 285             


Val Leu Gln Val Gly Phe Ser Thr Glu Ala Ala Leu Gln Asp Leu Ser 
    290                 295                 300                 


Ser Pro Arg Leu Ser Gln Leu Cys Ser Gln Gly Leu Cys Gly Leu Ile 
305                 310                 315                 320 


Lys Arg Pro Gly Asp Leu Pro Glu Val Leu Ser Phe His Val Asp Arg 
                325                 330                 335     


Val Leu Gly Leu Arg Arg Ser Leu Pro Ala Val Ala Arg Arg Phe His 
            340                 345                 350         


Ser Pro Leu Leu Pro Tyr Arg Tyr Thr Asp Gly Gly Ala Arg Pro Val 
        355                 360                 365             


Ile Trp Trp Ala Pro Asp Val Gln His Leu Ser Asp Pro Asp Glu Asp 
    370                 375                 380                 


Gln Asn Ser Leu Ala Leu Gly Trp Leu Gln Tyr Gln Ala Leu Leu Ala 
385                 390                 395                 400 


His Ser Cys Asn Trp Pro Gly Gln Ala Pro Cys Pro Gly Ile His His 
                405                 410                 415     


Thr Glu Trp Ala Arg Leu Ala Leu Phe Asp Phe Leu Leu Gln Val His 
            420                 425                 430         


Asp Arg Leu Asp Arg Tyr Cys Cys Gly Phe Glu Pro Glu Pro Ser Asp 
        435                 440                 445             


Pro Cys Val Glu Glu Arg Leu Arg Glu Lys Cys Gln Asn Pro Ala Glu 
    450                 455                 460                 


Leu Arg Leu Val His Ile Leu Val Arg Ser Ser Asp Pro Ser His Leu 
465                 470                 475                 480 


Val Tyr Ile Asp Asn Ala Gly Asn Leu Gln His Pro Glu Asp Lys Leu 
                485                 490                 495     


Asn Phe Arg Leu Leu Glu Gly Ile Asp Gly Phe Pro Glu Ser Ala Val 
            500                 505                 510         


Lys Val Leu Ala Ser Gly Cys Leu Gln Asn Met Leu Leu Lys Ser Leu 
        515                 520                 525             


Gln Met Asp Pro Val Phe Trp Glu Ser Gln Gly Gly Ala Gln Gly Leu 
    530                 535                 540                 


Lys Gln Val Leu Gln Thr Leu Glu Gln Arg Gly Gln Val Leu Leu Gly 
545                 550                 555                 560 


His Ile Gln Lys His Asn Leu Thr Leu Phe Arg Asp Glu Asp Pro 
                565                 570                 575 


<210>  5045
<211>  575
<212>  PRT
<213>  Homo Sapiens

<400>  5045

Met Ala Ser Trp Leu Arg Arg Lys Leu Arg Gly Lys Arg Arg Pro Val 
1               5                   10                  15      


Ile Ala Phe Cys Leu Leu Met Ile Leu Ser Ala Met Ala Val Thr Arg 
            20                  25                  30          


Phe Pro Pro Gln Arg Pro Ser Ala Gly Pro Asp Pro Gly Pro Met Glu 
        35                  40                  45              


Pro Gln Gly Val Thr Gly Ala Pro Ala Thr His Ile Arg Gln Ala Leu 
    50                  55                  60                  


Ser Ser Ser Arg Arg Gln Arg Ala Arg Asn Met Gly Phe Trp Arg Ser 
65                  70                  75                  80  


Arg Ala Leu Pro Arg Asn Ser Ile Leu Val Cys Ala Glu Glu Gln Gly 
                85                  90                  95      


His Arg Ala Arg Val Asp Arg Ser Arg Glu Ser Pro Gly Gly Asp Leu 
            100                 105                 110         


Arg His Pro Gly Arg Val Arg Arg Asp Ile Thr Leu Ser Gly His Pro 
        115                 120                 125             


Arg Leu Ser Thr Gln His Val Val Leu Leu Arg Glu Asp Glu Val Gly 
    130                 135                 140                 


Asp Pro Gly Thr Lys Asp Leu Gly His Pro Gln His Gly Ser Pro Ile 
145                 150                 155                 160 


Gln Glu Thr Gln Ser Glu Val Val Thr Leu Val Ser Pro Leu Pro Gly 
                165                 170                 175     


Ser Asp Met Ala Ala Leu Pro Ala Trp Arg Ala Thr Ser Gly Leu Thr 
            180                 185                 190         


Leu Trp Pro His Thr Ala Glu Gly Arg Asp Leu Leu Gly Ala Glu Asn 
        195                 200                 205             


Arg Ala Leu Thr Gly Gly Gln Gln Ala Glu Asp Pro Thr Leu Ala Ser 
    210                 215                 220                 


Gly Ala His Gln Trp Pro Gly Ser Val Glu Lys Leu Gln Gly Ser Val 
225                 230                 235                 240 


Trp Cys Asp Ala Glu Thr Leu Leu Ser Ser Ser Arg Thr Gly Gly Gln 
                245                 250                 255     


Ala Pro Pro Trp Leu Thr Asp His Asp Val Gln Met Leu Arg Leu Leu 
            260                 265                 270         


Ala Gln Gly Glu Val Val Asp Lys Ala Arg Val Pro Ala His Gly Gln 
        275                 280                 285             


Val Leu Gln Val Gly Phe Ser Thr Glu Ala Ala Leu Gln Asp Leu Ser 
    290                 295                 300                 


Ser Pro Arg Leu Ser Gln Leu Cys Ser Gln Gly Leu Cys Gly Leu Ile 
305                 310                 315                 320 


Lys Arg Pro Gly Asp Leu Pro Glu Val Leu Ser Phe His Val Asp Arg 
                325                 330                 335     


Val Leu Gly Leu Arg Arg Ser Leu Pro Ala Val Ala Arg Arg Phe His 
            340                 345                 350         


Ser Pro Leu Leu Pro Tyr Arg Tyr Thr Asp Gly Gly Ala Arg Pro Val 
        355                 360                 365             


Ile Trp Trp Ala Pro Asp Val Gln His Leu Ser Asp Pro Asp Glu Asp 
    370                 375                 380                 


Gln Asn Ser Leu Ala Leu Gly Trp Leu Gln Tyr Gln Ala Leu Leu Ala 
385                 390                 395                 400 


His Ser Cys Asn Trp Pro Gly Gln Ala Pro Cys Pro Gly Ile His His 
                405                 410                 415     


Thr Glu Trp Ala Arg Leu Ala Leu Phe Asp Phe Leu Leu Gln Val His 
            420                 425                 430         


Asp Arg Leu Asp Arg Tyr Cys Cys Gly Phe Glu Pro Glu Pro Ser Asp 
        435                 440                 445             


Pro Cys Val Glu Glu Arg Leu Arg Glu Lys Cys Gln Asn Pro Ala Glu 
    450                 455                 460                 


Leu Arg Leu Val His Ile Leu Val Arg Ser Ser Asp Pro Ser His Leu 
465                 470                 475                 480 


Val Tyr Ile Asp Asn Ala Gly Asn Leu Gln His Pro Glu Asp Lys Leu 
                485                 490                 495     


Asn Phe Arg Leu Leu Glu Gly Ile Asp Gly Phe Pro Glu Ser Ala Val 
            500                 505                 510         


Lys Val Leu Ala Ser Gly Cys Leu Gln Asn Met Leu Leu Lys Ser Leu 
        515                 520                 525             


Gln Met Asp Pro Val Phe Trp Glu Ser Gln Gly Gly Ala Gln Gly Leu 
    530                 535                 540                 


Lys Gln Val Leu Gln Thr Leu Glu Gln Arg Gly Gln Val Leu Leu Gly 
545                 550                 555                 560 


His Ile Gln Lys His Asn Leu Thr Leu Phe Arg Asp Glu Asp Pro 
                565                 570                 575 


<210>  5046
<211>  140
<212>  PRT
<213>  Homo Sapiens

<400>  5046

Met Val His Asp Arg Leu Asp Arg Tyr Cys Cys Gly Phe Glu Pro Glu 
1               5                   10                  15      


Pro Ser Asp Pro Cys Val Glu Glu Arg Leu Arg Glu Lys Cys Gln Asn 
            20                  25                  30          


Pro Ala Glu Leu Arg Leu Val His Ile Leu Val Arg Ser Ser Asp Pro 
        35                  40                  45              


Ser His Leu Val Tyr Ile Asp Asn Ala Gly Asn Leu Gln His Pro Glu 
    50                  55                  60                  


Asp Lys Leu Asn Phe Arg Leu Leu Glu Gly Ile Asp Gly Phe Pro Glu 
65                  70                  75                  80  


Ser Ala Val Lys Val Leu Ala Ser Gly Cys Leu Gln Asn Met Leu Leu 
                85                  90                  95      


Lys Ser Leu Gln Met Asp Pro Val Phe Trp Glu Ser Gln Gly Gly Ala 
            100                 105                 110         


Gln Gly Leu Lys Gln Val Leu Gln Thr Leu Glu Gln Arg Gly Gln Val 
        115                 120                 125             


Leu Leu Gly His Ile Gln Lys His Asn Leu Thr Leu 
    130                 135                 140 


<210>  5047
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  5047

Met Ala Met Val Ser Ala Met Ser Trp Val Leu Tyr Leu Trp Ile Ser 
1               5                   10                  15      


Ala Cys Ala Met Leu Leu Cys His Gly Ser Leu Gln His Thr Phe Gln 
            20                  25                  30          


Gln His His Leu His Arg Pro Glu Gly Gly Thr Cys Glu Val Ile Ala 
        35                  40                  45              


Ala His Arg Cys Cys Asn Lys Asn Arg Ile Glu Glu Arg Ser Gln Thr 
    50                  55                  60                  


Val Lys Cys Ser Cys Leu Pro Gly Lys Val Ala Gly Thr Thr Arg Asn 
65                  70                  75                  80  


Arg Pro Ser Cys Val Asp Ala Ser Ile Val Ile Gly Lys Trp Trp Cys 
                85                  90                  95      


Glu Met Glu Pro Cys Leu Glu Gly Glu Glu Cys Lys Thr Leu Pro Asp 
            100                 105                 110         


Asn Ser Gly Trp Met Cys Ala Thr Gly Asn Lys Ile Lys Thr Thr Arg 
        115                 120                 125             


Ile His Pro Arg Thr 
    130             


<210>  5048
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  5048

Met Ala Met Val Ser Ala Met Ser Trp Val Leu Tyr Leu Trp Ile Ser 
1               5                   10                  15      


Ala Cys Ala Met Leu Leu Cys His Gly Ser Leu Gln His Thr Phe Gln 
            20                  25                  30          


Gln His His Leu His Arg Pro Glu Gly Gly Thr Cys Glu Val Ile Ala 
        35                  40                  45              


Ala His Arg Cys Cys Asn Lys Asn Arg Ile Glu Glu Arg Ser Gln Thr 
    50                  55                  60                  


Val Lys Cys Ser Cys Leu Pro Gly Lys Val Ala Gly Thr Thr Arg Asn 
65                  70                  75                  80  


Arg Pro Ser Cys Val Asp Ala Ser Ile Val Ile Gly Lys Trp Trp Cys 
                85                  90                  95      


Glu Met Glu Pro Cys Leu Glu Gly Glu Glu Cys Lys Thr Leu Pro Asp 
            100                 105                 110         


Asn Ser Gly Trp Met Cys Ala Thr Gly Asn Lys Ile Lys Thr Thr Arg 
        115                 120                 125             


Ile His Pro Arg Thr 
    130             


<210>  5049
<211>  52
<212>  PRT
<213>  Homo Sapiens

<400>  5049

Pro Glu Gly Gly Thr Cys Glu Val Ile Ala Ala His Arg Cys Cys Asn 
1               5                   10                  15      


Lys Asn Arg Ile Glu Glu Arg Ser Gln Thr Val Lys Cys Ser Cys Leu 
            20                  25                  30          


Pro Gly Lys Val Ala Gly Thr Thr Arg Asn Arg Pro Ser Cys Val Asp 
        35                  40                  45              


Gly Ala Ile Ile 
    50          


<210>  5050
<211>  87
<212>  PRT
<213>  Homo Sapiens

<400>  5050

Met Met Ser Lys Arg Tyr Leu Gln Lys Ala Thr Lys Gly Lys Leu Leu 
1               5                   10                  15      


Ile Ile Ile Phe Ile Val Thr Leu Trp Gly Lys Val Val Ser Ser Ala 
            20                  25                  30          


Asn His His Lys Ala His His Val Lys Thr Gly Thr Cys Glu Val Val 
        35                  40                  45              


Ala Leu His Arg Cys Cys Asn Lys Asn Lys Ile Glu Glu Arg Ser Gln 
    50                  55                  60                  


Thr Val Lys Cys Ser Cys Phe Pro Gly Gln Val Ala Gly Thr Thr Arg 
65                  70                  75                  80  


Ala Ala Pro Ser Cys Val Asp 
                85          


<210>  5051
<211>  110
<212>  PRT
<213>  Homo Sapiens

<400>  5051

Met Met Ser Lys Arg Tyr Leu Gln Lys Ala Thr Lys Gly Lys Leu Leu 
1               5                   10                  15      


Ile Ile Ile Phe Ile Val Thr Leu Trp Gly Lys Val Val Ser Ser Ala 
            20                  25                  30          


Asn His His Lys Ala His His Val Lys Thr Gly Thr Cys Glu Val Val 
        35                  40                  45              


Ala Leu His Arg Cys Cys Asn Lys Asn Lys Ile Glu Glu Arg Ser Gln 
    50                  55                  60                  


Thr Val Lys Cys Ser Cys Phe Pro Gly Gln Val Ala Gly Thr Thr Arg 
65                  70                  75                  80  


Ala Ala Pro Ser Cys Val Asp Ala Ser Ile Val Glu Gln Lys Trp Trp 
                85                  90                  95      


Cys His Met Gln Pro Cys Leu Glu Gly Glu Glu Cys Lys Val 
            100                 105                 110 


<210>  5052
<211>  34
<212>  PRT
<213>  Homo Sapiens

<400>  5052

Met Gln Pro Cys Leu Glu Gly Glu Glu Cys Lys Val Leu Pro Asp Arg 
1               5                   10                  15      


Lys Gly Trp Ser Cys Ser Ser Gly Asn Lys Val Lys Thr Thr Arg Val 
            20                  25                  30          


Thr His 
        


<210>  5053
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  5053

Met Ser Lys Arg Tyr Leu Gln Lys Ala Thr Lys Gly Lys Leu Leu Ile 
1               5                   10                  15      


Ile Ile Phe Ile Val Thr Leu Trp Gly Lys Val Val Ser Ser Ala Asn 
            20                  25                  30          


His His Lys Ala His His Val Lys Thr Gly Thr Cys Glu Val Val Ala 
        35                  40                  45              


Leu His Arg Cys Cys Asn Lys Asn Lys Ile Glu Glu Arg Ser Gln Thr 
    50                  55                  60                  


Val Lys Cys Ser Cys Phe Pro Gly Gln Val Ala Gly Thr Thr Arg Ala 
65                  70                  75                  80  


Ala Pro Ser Cys Val Asp Ala Ser Ile Val Glu Gln Lys Trp Trp Cys 
                85                  90                  95      


His Met Gln Pro Cys Leu Glu Gly Glu Glu Cys Lys Val Leu Pro Asp 
            100                 105                 110         


Arg Lys Gly Trp Ser Cys Ser Ser Gly Asn Lys Val Lys Thr Thr Arg 
        115                 120                 125             


Ala Asn Val 
    130     


<210>  5054
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  5054

Met Ser Lys Arg Tyr Leu Gln Lys Ala Thr Lys Gly Lys Leu Leu Ile 
1               5                   10                  15      


Ile Ile Phe Ile Val Thr Leu Trp Gly Lys Val Val Ser Ser Ala Asn 
            20                  25                  30          


His His Lys Ala His His Val Lys Thr Gly Thr Cys Glu Val Val Ala 
        35                  40                  45              


Leu His Arg Cys Cys Asn Lys Asn Lys Ile Glu Glu Arg Ser Gln Thr 
    50                  55                  60                  


Val Lys Cys Ser Cys Phe Pro Gly Gln Val Ala Gly Thr Thr Arg Ala 
65                  70                  75                  80  


Ala Pro Ser Cys Val Asp Ala Ser Ile Val Glu Gln Lys Trp Trp Cys 
                85                  90                  95      


His Met Gln Pro Cys Leu Glu Gly Glu Glu Cys Lys Val Leu Pro Asp 
            100                 105                 110         


Arg Lys Gly Trp Ser Cys Ser Ser Gly Asn Lys Val Lys Thr Thr Arg 
        115                 120                 125             


Val Thr His 
    130     


<210>  5055
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  5055

Met Ser Lys Arg Tyr Leu Gln Lys Ala Thr Lys Gly Lys Leu Leu Ile 
1               5                   10                  15      


Ile Ile Phe Ile Val Thr Leu Trp Gly Lys Val Val Ser Ser Ala Asn 
            20                  25                  30          


His His Lys Ala His His Val Lys Thr Gly Thr Cys Glu Val Val Ala 
        35                  40                  45              


Leu His Arg Cys Cys Asn Lys Asn Lys Ile Glu Glu Arg Ser Gln Thr 
    50                  55                  60                  


Val Lys Cys Ser Cys Phe Pro Gly Gln Val Ala Gly Thr Thr Arg Ala 
65                  70                  75                  80  


Ala Pro Ser Cys Val Asp Ala Ser Ile Val Glu Gln Lys Trp Trp Cys 
                85                  90                  95      


His Met Gln Pro Cys Leu Glu Gly Glu Glu Cys Lys Val Leu Pro Asp 
            100                 105                 110         


Arg Lys Gly Trp Ser Cys Ser Ser Gly Asn Lys Val Lys Thr Thr Arg 
        115                 120                 125             


Val Thr His 
    130     


<210>  5056
<211>  49
<212>  PRT
<213>  Homo Sapiens

<400>  5056

Met Ser Lys Arg Tyr Leu Gln Lys Ala Thr Lys Gly Lys Leu Leu Ile 
1               5                   10                  15      


Ile Ile Phe Ile Val Thr Leu Trp Gly Lys Val Val Ser Ser Ala Asn 
            20                  25                  30          


His His Lys Gly Asn Pro Leu Thr Gln Glu Lys Ser Ser Asp Pro Gln 
        35                  40                  45              


Gly 
    


<210>  5057
<211>  101
<212>  PRT
<213>  Homo Sapiens

<400>  5057

Met Val Thr Pro Ile Thr Arg Met Ser Lys Arg Tyr Leu Gln Lys Ala 
1               5                   10                  15      


Thr Lys Gly Lys Leu Leu Ile Ile Ile Phe Ile Val Thr Leu Trp Gly 
            20                  25                  30          


Lys Val Val Ser Ser Ala Asn His His Lys Ala His His Val Lys Thr 
        35                  40                  45              


Gly Thr Cys Glu Val Val Ala Leu His Arg Cys Cys Asn Lys Asn Lys 
    50                  55                  60                  


Ile Glu Glu Arg Ser Gln Thr Val Lys Cys Ser Cys Phe Pro Gly Gln 
65                  70                  75                  80  


Val Ala Gly Thr Thr Arg Ala Ala Pro Ser Cys Val Asp Ala Ser Ile 
                85                  90                  95      


Val Glu Gln Lys Trp 
            100     


<210>  5058
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  5058

Met Ser Glu Arg Val Glu Arg Asn Trp Ser Thr Gly Gly Trp Leu Leu 
1               5                   10                  15      


Ala Leu Cys Leu Ala Trp Leu Trp Thr His Leu Thr Leu Ala Ala Leu 
            20                  25                  30          


Gln Pro Pro Thr Ala Thr Val Leu Val Gln Gln Gly Thr Cys Glu Val 
        35                  40                  45              


Ile Ala Ala His Arg Cys Cys Asn Arg Asn Arg Ile Glu Glu Arg Ser 
    50                  55                  60                  


Gln Thr Val Lys Cys Ser Cys Phe Ser Gly Gln Val Ala Gly Thr Thr 
65                  70                  75                  80  


Arg Ala Lys Pro Ser Cys Val Asp Ala Ser Ile Val Leu Gln Arg Trp 
                85                  90                  95      


Trp Cys Gln Met Glu Pro Cys Leu Pro Gly Glu Glu Cys Lys Val Leu 
            100                 105                 110         


Pro Asp Leu Ser Gly Trp Ser Cys Ser Ser Gly His Lys Val Lys Thr 
        115                 120                 125             


Thr Lys Val Thr Arg 
    130             


<210>  5059
<211>  169
<212>  PRT
<213>  Homo Sapiens

<400>  5059

Met Ser Glu Arg Val Glu Arg Asn Trp Ser Thr Gly Gly Trp Leu Leu 
1               5                   10                  15      


Ala Leu Cys Leu Ala Trp Leu Trp Thr His Leu Thr Leu Ala Ala Leu 
            20                  25                  30          


Gln Pro Pro Thr Ala Thr Val Leu Val Gln Gln Gly Thr Cys Glu Val 
        35                  40                  45              


Ile Ala Ala His Arg Cys Cys Asn Arg Asn Arg Ile Glu Glu Arg Ser 
    50                  55                  60                  


Gln Thr Val Lys Cys Ser Cys Phe Ser Gly Gln Val Ala Gly Thr Thr 
65                  70                  75                  80  


Arg Ala Lys Pro Ser Cys Val Asp Asp Leu Leu Leu Ala Ala His Cys 
                85                  90                  95      


Ala Arg Arg Asp Pro Arg Ala Ala Leu Arg Leu Leu Leu Pro Gln Pro 
            100                 105                 110         


Pro Ser Ser Cys Arg Asp Gly Gly Val Arg Trp Ser Pro Ala Cys Arg 
        115                 120                 125             


Gly Arg Ser Val Arg Cys Ser Arg Thr Cys Arg Asp Gly Ala Ala Ala 
    130                 135                 140                 


Val Asp Thr Lys Ser Lys Pro Pro Arg Ser His Asp Ser Ser Trp Gly 
145                 150                 155                 160 


Ser Arg Pro Gly Gln Glu Arg Leu Asp 
                165                 


<210>  5060
<211>  58
<212>  PRT
<213>  Homo Sapiens

<400>  5060

Met Arg Ser Pro Arg Met Arg Val Cys Ala Lys Ser Val Leu Leu Ser 
1               5                   10                  15      


His Trp Leu Phe Leu Ala Tyr Val Leu Met Val Cys Cys Lys Leu Met 
            20                  25                  30          


Ser Ala Ser Ser Gln His Leu Arg Gly His Ala Gly His His Gln Ile 
        35                  40                  45              


Lys Gln Gly Thr Cys Glu Val Val Ala Val 
    50                  55              


<210>  5061
<211>  77
<212>  PRT
<213>  Homo Sapiens

<400>  5061

Met Arg Ser Pro Arg Met Arg Val Cys Ala Lys Ser Val Leu Leu Ser 
1               5                   10                  15      


His Trp Leu Phe Leu Ala Tyr Val Leu Met Val Cys Cys Lys Leu Met 
            20                  25                  30          


Ser Ala Ser Ser Gln His Leu Arg Gly His Ala Gly His His Gln Ile 
        35                  40                  45              


Lys Gln Gly Thr Cys Glu Val Val Ala Val His Arg Cys Cys Asn Lys 
    50                  55                  60                  


Asn Arg Ile Glu Glu Arg Ser Gln Thr Val Lys Cys Ser 
65                  70                  75          


<210>  5062
<211>  140
<212>  PRT
<213>  Homo Sapiens

<400>  5062

Met Arg Ser Pro Arg Met Arg Val Cys Ala Lys Ser Val Leu Leu Ser 
1               5                   10                  15      


His Trp Leu Phe Leu Ala Tyr Val Leu Met Val Cys Cys Lys Leu Met 
            20                  25                  30          


Ser Ala Ser Ser Gln His Leu Arg Gly His Ala Gly His His Gln Ile 
        35                  40                  45              


Lys Gln Gly Thr Cys Glu Val Val Ala Val His Arg Cys Cys Asn Lys 
    50                  55                  60                  


Asn Arg Ile Glu Glu Arg Ser Gln Thr Val Lys Cys Ser Cys Phe Pro 
65                  70                  75                  80  


Gly Gln Val Ala Gly Thr Thr Arg Ala Gln Pro Ser Cys Val Glu Ala 
                85                  90                  95      


Ser Ile Val Ile Gln Lys Trp Trp Cys His Met Asn Pro Cys Leu Glu 
            100                 105                 110         


Gly Glu Asp Cys Lys Val Leu Pro Asp Tyr Ser Gly Trp Ser Cys Ser 
        115                 120                 125             


Ser Gly Asn Lys Val Lys Thr Thr Lys Val Thr Arg 
    130                 135                 140 


<210>  5063
<211>  181
<212>  PRT
<213>  Homo Sapiens

<400>  5063

Met Ala Pro Ser Pro Arg Thr Gly Ser Arg Gln Asp Ala Thr Ala Leu 
1               5                   10                  15      


Pro Ser Met Ser Ser Thr Phe Trp Ala Phe Met Ile Leu Ala Ser Leu 
            20                  25                  30          


Leu Ile Ala Tyr Cys Ser Gln Leu Ala Ala Gly Thr Cys Glu Ile Val 
        35                  40                  45              


Thr Leu Asp Arg Asp Ser Ser Gln Pro Arg Arg Thr Ile Ala Arg Gln 
    50                  55                  60                  


Thr Ala Arg Cys Ala Cys Arg Lys Gly Gln Ile Ala Gly Thr Thr Arg 
65                  70                  75                  80  


Ala Arg Pro Ala Cys Val Asp Ala Arg Ile Ile Lys Thr Lys Gln Trp 
                85                  90                  95      


Cys Asp Met Leu Pro Cys Leu Glu Gly Glu Gly Cys Asp Leu Leu Ile 
            100                 105                 110         


Asn Arg Ser Gly Trp Thr Cys Thr Gln Pro Gly Gly Arg Ile Lys Thr 
        115                 120                 125             


Thr Thr Ser Pro Ser Lys Pro Pro Lys Arg Ala Pro Pro Gly Ile Pro 
    130                 135                 140                 


Ser Cys Arg Gln Arg Ala Gly Gly Ser Leu Gly Ser Arg Asp Leu Arg 
145                 150                 155                 160 


Thr Ser Leu Leu Cys Gln Gly Ser His Leu Ala Asp Arg Arg Arg Trp 
                165                 170                 175     


Leu Arg Pro Ser Gln 
            180     


<210>  5064
<211>  132
<212>  PRT
<213>  Homo Sapiens

<400>  5064

Met Ala Pro Ser Pro Arg Thr Gly Ser Arg Gln Asp Ala Thr Ala Leu 
1               5                   10                  15      


Pro Ser Met Ser Ser Thr Phe Trp Ala Phe Met Ile Leu Ala Ser Leu 
            20                  25                  30          


Leu Ile Ala Tyr Cys Ser Gln Leu Ala Ala Gly Thr Cys Glu Ile Val 
        35                  40                  45              


Thr Leu Asp Arg Asp Ser Ser Gln Pro Arg Arg Thr Ile Ala Arg Gln 
    50                  55                  60                  


Thr Ala Arg Cys Ala Cys Arg Lys Gly Gln Ile Ala Gly Thr Thr Arg 
65                  70                  75                  80  


Ala Arg Pro Ala Cys Val Asp Ala Arg Ile Ile Lys Thr Lys Gln Trp 
                85                  90                  95      


Cys Asp Met Leu Pro Cys Leu Glu Gly Glu Gly Cys Asp Leu Leu Ile 
            100                 105                 110         


Asn Arg Ser Gly Trp Thr Cys Thr Gln Pro Gly Gly Arg Ile Lys Thr 
        115                 120                 125             


Thr Thr Val Ser 
    130         


<210>  5065
<211>  125
<212>  PRT
<213>  Homo Sapiens

<400>  5065

Met Gln Leu Leu Lys Ala Leu Trp Ala Leu Ala Gly Ala Ala Leu Cys 
1               5                   10                  15      


Cys Phe Leu Val Leu Val Ile His Ala Gln Phe Leu Lys Glu Gly Gln 
            20                  25                  30          


Leu Ala Ala Gly Thr Cys Glu Ile Val Thr Leu Asp Arg Asp Ser Ser 
        35                  40                  45              


Gln Pro Arg Arg Thr Ile Ala Arg Gln Thr Ala Arg Cys Ala Cys Arg 
    50                  55                  60                  


Lys Gly Gln Ile Ala Gly Thr Thr Arg Ala Arg Pro Ala Cys Val Asp 
65                  70                  75                  80  


Ala Arg Ile Ile Lys Thr Lys Gln Trp Cys Asp Met Leu Pro Cys Leu 
                85                  90                  95      


Glu Gly Glu Gly Cys Asp Leu Leu Ile Asn Arg Ser Gly Trp Thr Cys 
            100                 105                 110         


Thr Gln Pro Gly Gly Arg Ile Lys Thr Thr Thr Val Ser 
        115                 120                 125 


<210>  5066
<211>  53
<212>  PRT
<213>  Homo Sapiens

<400>  5066

Met Tyr His His Arg Glu Trp Pro Ala Arg Ile Ile Lys Thr Lys Gln 
1               5                   10                  15      


Trp Cys Asp Met Leu Pro Cys Leu Glu Gly Glu Gly Cys Asp Leu Leu 
            20                  25                  30          


Ile Asn Arg Ser Gly Trp Thr Cys Thr Gln Pro Gly Gly Arg Ile Lys 
        35                  40                  45              


Thr Thr Thr Val Ser 
    50              


<210>  5067
<211>  145
<212>  PRT
<213>  Homo Sapiens

<400>  5067

Met Phe Thr Ser Pro Ser Glu Gly Lys Pro Gly Asn Met Asp Arg His 
1               5                   10                  15      


His Tyr Glu Met Phe Thr Lys Phe Gly Asp Asp Gly Phe Leu Ile His 
            20                  25                  30          


Leu Asp Asn Ala Arg Gly Phe Gly Arg His Ser His Asp Glu Ile Ser 
        35                  40                  45              


Ile Leu Ser Pro Leu Ser Gln Cys Cys Met Ile Lys Lys Lys Thr Leu 
    50                  55                  60                  


Leu His Leu Gln Leu Leu Ala Gln Ala Asp Tyr Arg Leu Ser Asp Val 
65                  70                  75                  80  


Met Arg Glu Ser Leu Leu Glu Asp Gln Leu Ser Pro Val Leu Thr Glu 
                85                  90                  95      


Pro His Leu Leu Ala Leu Asp Arg Arg Leu Gln Thr Ile Leu Arg Thr 
            100                 105                 110         


Val Glu Gly Cys Ile Val Ala His Gly Gln Gln Ser Val Ile Val Asp 
        115                 120                 125             


Gly Pro Val Glu Gln Leu Ala Pro Asp Ser Gly Gln Ala Asn Leu Thr 
    130                 135                 140                 


Ser 
145 


<210>  5068
<211>  541
<212>  PRT
<213>  Homo Sapiens

<400>  5068

Met Pro Gly Leu Arg Arg Asp Arg Leu Leu Thr Leu Leu Leu Leu Gly 
1               5                   10                  15      


Ala Leu Leu Ser Ala Asp Leu Tyr Phe His Leu Trp Pro Gln Val Gln 
            20                  25                  30          


Arg Gln Leu Arg Pro Arg Glu Arg Pro Arg Gly Cys Pro Cys Thr Gly 
        35                  40                  45              


Arg Ala Ser Ser Leu Ala Arg Asp Ser Ala Ala Ala Ala Ser Asp Pro 
    50                  55                  60                  


Gly Thr Ile Val His Asn Phe Ser Arg Thr Glu Pro Arg Thr Glu Pro 
65                  70                  75                  80  


Ala Gly Gly Ser His Ser Gly Ser Ser Ser Lys Leu Gln Ala Leu Phe 
                85                  90                  95      


Ala His Pro Leu Tyr Asn Val Pro Glu Glu Pro Pro Leu Leu Gly Ala 
            100                 105                 110         


Glu Asp Ser Leu Leu Ala Ser Gln Glu Ala Leu Arg Tyr Tyr Arg Arg 
        115                 120                 125             


Lys Val Ala Arg Trp Asn Arg Arg His Lys Met Tyr Arg Glu Gln Met 
    130                 135                 140                 


Asn Leu Thr Ser Leu Asp Pro Pro Leu Gln Leu Arg Leu Glu Ala Ser 
145                 150                 155                 160 


Trp Val Gln Phe His Leu Gly Ile Asn Arg His Gly Leu Tyr Ser Arg 
                165                 170                 175     


Ser Ser Pro Val Val Ser Lys Leu Leu Gln Asp Met Arg His Phe Pro 
            180                 185                 190         


Thr Ile Ser Ala Asp Tyr Ser Gln Asp Glu Lys Ala Leu Leu Gly Ala 
        195                 200                 205             


Cys Asp Cys Thr Gln Ile Val Lys Pro Ser Gly Val His Leu Lys Leu 
    210                 215                 220                 


Val Leu Arg Phe Ser Asp Phe Gly Lys Ala Met Phe Lys Pro Met Arg 
225                 230                 235                 240 


Gln Gln Arg Asp Glu Glu Thr Pro Val Asp Phe Phe Tyr Phe Ile Asp 
                245                 250                 255     


Phe Gln Arg His Asn Ala Glu Ile Ala Ala Phe His Leu Asp Arg Ile 
            260                 265                 270         


Leu Asp Phe Arg Arg Val Pro Pro Thr Val Gly Arg Ile Val Asn Val 
        275                 280                 285             


Thr Lys Glu Ile Leu Glu Val Thr Lys Asn Glu Ile Leu Gln Ser Val 
    290                 295                 300                 


Phe Phe Val Ser Pro Ala Ser Asn Val Cys Phe Phe Ala Lys Cys Pro 
305                 310                 315                 320 


Tyr Met Cys Lys Thr Glu Tyr Ala Val Cys Gly Asn Pro His Leu Leu 
                325                 330                 335     


Glu Gly Ser Leu Ser Ala Phe Leu Pro Ser Leu Asn Leu Ala Pro Arg 
            340                 345                 350         


Leu Ser Val Pro Asn Pro Trp Ile Arg Ser Tyr Thr Leu Ala Gly Lys 
        355                 360                 365             


Glu Glu Trp Glu Val Asn Pro Leu Tyr Cys Asp Thr Val Lys Gln Ile 
    370                 375                 380                 


Tyr Pro Tyr Asn Asn Ser Gln Arg Leu Leu Asn Val Ile Asp Met Ala 
385                 390                 395                 400 


Ile Phe Asp Phe Leu Ile Gly Asn Met Asp Arg His His Tyr Glu Met 
                405                 410                 415     


Phe Thr Lys Phe Gly Asp Asp Gly Phe Leu Ile His Leu Asp Asn Ala 
            420                 425                 430         


Arg Gly Phe Gly Arg His Ser His Asp Glu Ile Ser Ile Leu Ser Pro 
        435                 440                 445             


Leu Ser Gln Cys Cys Met Ile Lys Lys Lys Thr Leu Leu His Leu Gln 
    450                 455                 460                 


Leu Leu Ala Gln Ala Asp Tyr Arg Leu Ser Asp Val Met Arg Glu Ser 
465                 470                 475                 480 


Leu Leu Glu Asp Gln Leu Ser Pro Val Leu Thr Glu Pro His Leu Leu 
                485                 490                 495     


Ala Leu Asp Arg Arg Leu Gln Thr Ile Leu Arg Thr Val Glu Gly Cys 
            500                 505                 510         


Ile Val Ala His Gly Gln Gln Ser Val Ile Val Asp Gly Pro Val Glu 
        515                 520                 525             


Gln Leu Ala Pro Asp Ser Gly Gln Ala Asn Leu Thr Ser 
    530                 535                 540     


<210>  5069
<211>  21
<212>  PRT
<213>  Homo Sapiens

<400>  5069

Gln Arg His Asn Ala Glu Ile Ala Ala Phe His Leu Asp Arg Glu Tyr 
1               5                   10                  15      


Gly Pro Ala Pro Leu 
            20      


<210>  5070
<211>  127
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5070

Xaa Phe His Leu Trp Pro Gln Val Gln Arg Gln Leu Arg Pro Arg Glu 
1               5                   10                  15      


Arg Pro Arg Gly Cys Pro Cys Thr Gly Arg Ala Ser Ser Leu Ala Arg 
            20                  25                  30          


Asp Ser Ala Ala Ala Ala Ser Asp Pro Gly Thr Ile Val His Asn Phe 
        35                  40                  45              


Ser Arg Thr Glu Pro Arg Thr Glu Pro Ala Gly Gly Ser His Ser Gly 
    50                  55                  60                  


Ser Ser Ser Lys Leu Gln Ala Leu Phe Ala His Pro Leu Tyr Asn Val 
65                  70                  75                  80  


Pro Glu Glu Pro Pro Leu Leu Gly Ala Glu Asp Ser Leu Leu Ala Ser 
                85                  90                  95      


Gln Glu Ala Leu Arg Tyr Tyr Arg Arg Lys Val Ala Arg Trp Asn Arg 
            100                 105                 110         


Pro Gln Phe Leu Leu Leu Lys Gly Arg Gly Gly Val Cys Asp Pro 
        115                 120                 125         


<210>  5071
<211>  584
<212>  PRT
<213>  Homo Sapiens

<400>  5071

Met Lys Met Met Leu Val Arg Arg Phe Arg Val Leu Ile Leu Met Val 
1               5                   10                  15      


Phe Leu Val Ala Cys Ala Leu His Ile Ala Leu Asp Leu Leu Pro Arg 
            20                  25                  30          


Leu Glu Arg Arg Gly Ala Arg Pro Ser Gly Glu Pro Gly Cys Ser Cys 
        35                  40                  45              


Ala Gln Pro Ala Ala Glu Val Ala Ala Pro Gly Trp Ala Gln Val Arg 
    50                  55                  60                  


Gly Arg Pro Gly Glu Pro Pro Ala Ala Ser Ser Ala Ala Gly Asp Ala 
65                  70                  75                  80  


Gly Trp Pro Asn Lys His Thr Leu Arg Ile Leu Gln Asp Phe Ser Ser 
                85                  90                  95      


Asp Pro Ser Ser Asn Leu Ser Ser His Ser Leu Glu Lys Leu Pro Pro 
            100                 105                 110         


Ala Ala Glu Pro Ala Glu Arg Ala Leu Arg Gly Arg Asp Pro Gly Ala 
        115                 120                 125             


Leu Arg Pro His Asp Pro Ala His Arg Pro Leu Leu Arg Asp Pro Gly 
    130                 135                 140                 


Pro Arg Arg Ser Glu Ser Pro Pro Gly Pro Gly Gly Asp Ala Ser Leu 
145                 150                 155                 160 


Leu Ala Arg Leu Phe Glu His Pro Leu Tyr Arg Val Ala Val Pro Pro 
                165                 170                 175     


Leu Thr Glu Glu Asp Val Leu Phe Asn Val Asn Ser Asp Thr Arg Leu 
            180                 185                 190         


Ser Pro Lys Ala Ala Glu Asn Pro Asp Trp Pro His Ala Gly Ala Glu 
        195                 200                 205             


Gly Ala Glu Phe Leu Ser Pro Gly Glu Ala Ala Val Asp Ser Tyr Pro 
    210                 215                 220                 


Asn Trp Leu Lys Phe His Ile Gly Ile Asn Arg Tyr Glu Leu Tyr Ser 
225                 230                 235                 240 


Arg His Asn Pro Ala Ile Glu Ala Leu Leu His Asp Leu Ser Ser Gln 
                245                 250                 255     


Arg Ile Thr Ser Val Ala Met Lys Ser Gly Gly Thr Gln Leu Lys Leu 
            260                 265                 270         


Ile Met Thr Phe Gln Asn Tyr Gly Gln Ala Leu Phe Lys Pro Met Lys 
        275                 280                 285             


Gln Thr Arg Glu Gln Glu Thr Pro Pro Asp Phe Phe Tyr Phe Ser Asp 
    290                 295                 300                 


Tyr Glu Arg His Asn Ala Glu Ile Ala Ala Phe His Leu Asp Arg Ile 
305                 310                 315                 320 


Leu Asp Phe Arg Arg Val Pro Pro Val Ala Gly Arg Met Val Asn Met 
                325                 330                 335     


Thr Lys Glu Ile Arg Asp Val Thr Arg Asp Lys Lys Leu Trp Arg Thr 
            340                 345                 350         


Phe Phe Ile Ser Pro Ala Asn Asn Ile Cys Phe Tyr Gly Glu Cys Ser 
        355                 360                 365             


Tyr Tyr Cys Ser Thr Glu His Ala Leu Cys Gly Lys Pro Asp Gln Ile 
    370                 375                 380                 


Glu Gly Ser Leu Ala Ala Phe Leu Pro Asp Leu Ser Leu Ala Lys Arg 
385                 390                 395                 400 


Lys Thr Trp Arg Asn Pro Trp Arg Arg Ser Tyr His Lys Arg Lys Lys 
                405                 410                 415     


Ala Glu Trp Glu Val Asp Pro Asp Tyr Cys Glu Glu Val Lys Gln Thr 
            420                 425                 430         


Pro Pro Tyr Asp Ser Ser His Arg Ile Leu Asp Val Met Asp Met Thr 
        435                 440                 445             


Ile Phe Asp Phe Leu Met Gly Asn Met Asp Arg His His Tyr Glu Thr 
    450                 455                 460                 


Phe Glu Lys Phe Gly Asn Glu Thr Phe Ile Ile His Leu Asp Asn Gly 
465                 470                 475                 480 


Arg Gly Phe Gly Lys Tyr Ser His Asp Glu Leu Ser Ile Leu Val Pro 
                485                 490                 495     


Leu Gln Gln Cys Cys Arg Ile Arg Lys Ser Thr Tyr Leu Arg Leu Gln 
            500                 505                 510         


Leu Leu Ala Lys Glu Glu Tyr Lys Leu Ser Leu Leu Met Ala Glu Ser 
        515                 520                 525             


Leu Arg Gly Asp Gln Val Ala Pro Val Leu Tyr Gln Pro His Leu Glu 
    530                 535                 540                 


Ala Leu Asp Arg Arg Leu Arg Val Val Leu Lys Ala Val Arg Asp Cys 
545                 550                 555                 560 


Val Glu Arg Asn Gly Leu His Ser Val Val Asp Asp Asp Leu Asp Thr 
                565                 570                 575     


Glu His Arg Ala Ala Ser Ala Arg 
            580                 


<210>  5072
<211>  218
<212>  PRT
<213>  Homo Sapiens

<400>  5072

Met Gly Met Trp Ser Ile Gly Ala Gly Ala Leu Gly Ala Ala Ala Leu 
1               5                   10                  15      


Ala Leu Leu Leu Ala Asn Thr Asp Val Phe Leu Ser Lys Pro Gln Lys 
            20                  25                  30          


Ala Ala Leu Glu Tyr Leu Glu Asp Ile Asp Leu Lys Thr Leu Glu Lys 
        35                  40                  45              


Glu Pro Arg Thr Phe Lys Ala Lys Glu Leu Trp Glu Lys Asn Gly Ala 
    50                  55                  60                  


Val Ile Met Ala Val Arg Arg Pro Gly Cys Phe Leu Cys Arg Glu Glu 
65                  70                  75                  80  


Ala Ala Asp Leu Ser Ser Leu Lys Ser Met Leu Asp Gln Leu Gly Val 
                85                  90                  95      


Pro Leu Tyr Ala Val Val Lys Glu His Ile Arg Thr Glu Val Lys Asp 
            100                 105                 110         


Phe Gln Pro Tyr Phe Lys Gly Glu Ile Phe Leu Asp Glu Lys Lys Lys 
        115                 120                 125             


Phe Tyr Gly Pro Gln Arg Arg Lys Met Met Phe Met Gly Phe Ile Arg 
    130                 135                 140                 


Leu Gly Val Trp Tyr Asn Phe Phe Arg Ala Trp Asn Gly Gly Phe Ser 
145                 150                 155                 160 


Gly Asn Leu Glu Gly Glu Gly Phe Ile Leu Gly Gly Val Phe Val Val 
                165                 170                 175     


Gly Ser Gly Lys Gln Gly Ile Leu Leu Glu His Arg Glu Lys Glu Phe 
            180                 185                 190         


Gly Asp Lys Val Asn Leu Leu Ser Val Leu Glu Ala Ala Lys Met Ile 
        195                 200                 205             


Lys Pro Gln Thr Leu Ala Ser Glu Lys Lys 
    210                 215             


<210>  5073
<211>  229
<212>  PRT
<213>  Homo Sapiens

<400>  5073

Met Ser Phe Leu Gln Asp Pro Ser Phe Phe Thr Met Gly Met Trp Ser 
1               5                   10                  15      


Ile Gly Ala Gly Ala Leu Gly Ala Ala Ala Leu Ala Leu Leu Leu Ala 
            20                  25                  30          


Asn Thr Asp Val Phe Leu Ser Lys Pro Gln Lys Ala Ala Leu Glu Tyr 
        35                  40                  45              


Leu Glu Asp Ile Asp Leu Lys Thr Leu Glu Lys Glu Pro Arg Thr Phe 
    50                  55                  60                  


Lys Ala Lys Glu Leu Trp Glu Lys Asn Gly Ala Val Ile Met Ala Val 
65                  70                  75                  80  


Arg Arg Pro Gly Cys Phe Leu Cys Arg Glu Glu Ala Ala Asp Leu Ser 
                85                  90                  95      


Ser Leu Lys Ser Met Leu Asp Gln Leu Gly Val Pro Leu Tyr Ala Val 
            100                 105                 110         


Val Lys Glu His Ile Arg Thr Glu Val Lys Asp Phe Gln Pro Tyr Phe 
        115                 120                 125             


Lys Gly Glu Ile Phe Leu Asp Glu Lys Lys Lys Phe Tyr Gly Pro Gln 
    130                 135                 140                 


Arg Arg Lys Met Met Phe Met Gly Phe Ile Arg Leu Gly Val Trp Tyr 
145                 150                 155                 160 


Asn Phe Phe Arg Ala Trp Asn Gly Gly Phe Ser Gly Asn Leu Glu Gly 
                165                 170                 175     


Glu Gly Phe Ile Leu Gly Gly Val Phe Val Val Gly Ser Gly Lys Gln 
            180                 185                 190         


Gly Ile Leu Leu Glu His Arg Glu Lys Glu Phe Gly Asp Lys Val Asn 
        195                 200                 205             


Leu Leu Ser Val Leu Glu Ala Ala Lys Met Ile Lys Pro Gln Thr Leu 
    210                 215                 220                 


Ala Ser Glu Lys Lys 
225                 


<210>  5074
<211>  229
<212>  PRT
<213>  Homo Sapiens

<400>  5074

Met Ser Phe Leu Gln Asp Pro Ser Phe Phe Thr Met Gly Met Trp Ser 
1               5                   10                  15      


Ile Gly Ala Gly Ala Leu Gly Ala Ala Ala Leu Ala Leu Leu Leu Ala 
            20                  25                  30          


Asn Thr Asp Val Phe Leu Ser Lys Pro Gln Lys Ala Ala Leu Glu Tyr 
        35                  40                  45              


Leu Glu Asp Ile Asp Leu Lys Thr Leu Glu Lys Glu Pro Arg Thr Phe 
    50                  55                  60                  


Lys Ala Lys Glu Leu Trp Glu Lys Asn Gly Ala Val Ile Met Ala Val 
65                  70                  75                  80  


Arg Arg Pro Gly Cys Phe Leu Cys Arg Glu Glu Ala Ala Asp Leu Ser 
                85                  90                  95      


Ser Leu Lys Ser Met Leu Asp Gln Leu Gly Val Pro Leu Tyr Ala Val 
            100                 105                 110         


Val Lys Glu His Ile Arg Thr Glu Val Lys Asp Phe Gln Pro Tyr Phe 
        115                 120                 125             


Lys Gly Glu Ile Phe Leu Asp Glu Lys Lys Lys Phe Tyr Gly Pro Gln 
    130                 135                 140                 


Arg Arg Lys Met Met Phe Met Gly Phe Ile Arg Leu Gly Val Trp Tyr 
145                 150                 155                 160 


Asn Phe Phe Arg Ala Trp Asn Gly Gly Phe Ser Gly Asn Leu Glu Gly 
                165                 170                 175     


Glu Gly Phe Ile Leu Gly Gly Val Phe Val Val Gly Ser Gly Lys Gln 
            180                 185                 190         


Gly Ile Leu Leu Glu His Arg Glu Lys Glu Phe Gly Asp Lys Val Asn 
        195                 200                 205             


Leu Leu Ser Val Leu Glu Ala Ala Lys Met Ile Lys Pro Gln Thr Leu 
    210                 215                 220                 


Ala Ser Glu Lys Lys 
225                 


<210>  5075
<211>  229
<212>  PRT
<213>  Homo Sapiens

<400>  5075

Met Ser Phe Leu Gln Asp Pro Ser Phe Phe Thr Met Gly Met Trp Ser 
1               5                   10                  15      


Ile Gly Ala Gly Ala Leu Gly Ala Ala Ala Leu Ala Leu Leu Leu Ala 
            20                  25                  30          


Asn Thr Asp Val Phe Leu Ser Lys Pro Gln Lys Ala Ala Leu Glu Tyr 
        35                  40                  45              


Leu Glu Asp Ile Asp Leu Lys Thr Leu Glu Lys Glu Pro Arg Thr Phe 
    50                  55                  60                  


Lys Ala Lys Glu Leu Trp Glu Lys Asn Gly Ala Val Ile Met Ala Val 
65                  70                  75                  80  


Arg Arg Pro Gly Cys Phe Leu Cys Arg Glu Glu Ala Ala Asp Leu Ser 
                85                  90                  95      


Ser Leu Lys Ser Met Leu Asp Gln Leu Gly Val Pro Leu Tyr Ala Val 
            100                 105                 110         


Val Lys Glu His Ile Arg Thr Glu Val Lys Asp Phe Gln Pro Tyr Phe 
        115                 120                 125             


Lys Gly Glu Ile Phe Leu Asp Glu Lys Lys Lys Phe Tyr Gly Pro Gln 
    130                 135                 140                 


Arg Arg Lys Met Met Phe Met Gly Phe Ile Arg Leu Gly Val Trp Tyr 
145                 150                 155                 160 


Asn Phe Phe Arg Ala Trp Asn Gly Gly Phe Ser Gly Asn Leu Glu Gly 
                165                 170                 175     


Glu Gly Phe Ile Leu Gly Gly Val Phe Val Val Gly Ser Gly Lys Gln 
            180                 185                 190         


Gly Ile Leu Leu Glu His Arg Glu Lys Glu Phe Gly Asp Lys Val Asn 
        195                 200                 205             


Leu Leu Ser Val Leu Glu Ala Ala Lys Met Ile Lys Pro Gln Thr Leu 
    210                 215                 220                 


Ala Ser Glu Lys Lys 
225                 


<210>  5076
<211>  229
<212>  PRT
<213>  Homo Sapiens

<400>  5076

Met Ser Phe Leu Gln Asp Pro Ser Phe Phe Thr Met Gly Met Trp Ser 
1               5                   10                  15      


Ile Gly Ala Gly Ala Leu Gly Ala Ala Ala Leu Ala Leu Leu Leu Ala 
            20                  25                  30          


Asn Thr Asp Val Phe Leu Ser Lys Pro Gln Lys Ala Ala Leu Glu Tyr 
        35                  40                  45              


Leu Glu Asp Ile Asp Leu Lys Thr Leu Glu Lys Glu Pro Arg Thr Phe 
    50                  55                  60                  


Lys Ala Lys Glu Leu Trp Glu Lys Asn Gly Ala Val Ile Met Ala Val 
65                  70                  75                  80  


Arg Arg Pro Gly Cys Phe Leu Cys Arg Glu Glu Ala Ala Asp Leu Ser 
                85                  90                  95      


Ser Leu Lys Ser Met Leu Asp Gln Leu Gly Val Pro Leu Tyr Ala Val 
            100                 105                 110         


Val Lys Glu His Ile Arg Thr Glu Val Lys Asp Phe Gln Pro Tyr Phe 
        115                 120                 125             


Lys Gly Glu Ile Phe Leu Asp Glu Lys Lys Lys Phe Tyr Gly Pro Gln 
    130                 135                 140                 


Arg Arg Lys Met Met Phe Met Gly Phe Ile Arg Leu Gly Val Trp Tyr 
145                 150                 155                 160 


Asn Phe Phe Arg Ala Trp Asn Gly Gly Phe Ser Gly Asn Leu Glu Gly 
                165                 170                 175     


Glu Gly Phe Ile Leu Gly Gly Val Phe Val Val Gly Ser Gly Lys Gln 
            180                 185                 190         


Gly Ile Leu Leu Glu His Arg Glu Lys Glu Phe Gly Asp Lys Val Asn 
        195                 200                 205             


Leu Leu Ser Val Leu Glu Ala Ala Lys Met Ile Lys Pro Gln Thr Leu 
    210                 215                 220                 


Ala Ser Glu Lys Lys 
225                 


<210>  5077
<211>  229
<212>  PRT
<213>  Homo Sapiens

<400>  5077

Met Ser Phe Leu Gln Asp Pro Ser Phe Phe Thr Met Gly Met Trp Ser 
1               5                   10                  15      


Ile Gly Ala Gly Ala Leu Gly Ala Ala Ala Leu Ala Leu Leu Leu Ala 
            20                  25                  30          


Asn Thr Asp Val Phe Leu Ser Lys Pro Gln Lys Ala Ala Leu Glu Tyr 
        35                  40                  45              


Leu Glu Asp Ile Asp Leu Lys Thr Leu Glu Lys Glu Pro Arg Thr Phe 
    50                  55                  60                  


Lys Ala Lys Glu Leu Trp Glu Lys Asn Gly Ala Val Ile Met Ala Val 
65                  70                  75                  80  


Arg Arg Pro Gly Cys Phe Leu Cys Arg Glu Glu Ala Ala Asp Leu Ser 
                85                  90                  95      


Ser Leu Lys Ser Met Leu Asp Gln Leu Gly Val Pro Leu Tyr Ala Val 
            100                 105                 110         


Val Lys Glu His Ile Arg Thr Glu Val Lys Asp Phe Gln Pro Tyr Phe 
        115                 120                 125             


Lys Gly Glu Ile Phe Leu Asp Glu Lys Lys Lys Phe Tyr Gly Pro Gln 
    130                 135                 140                 


Arg Arg Lys Met Met Phe Met Gly Phe Ile Arg Leu Gly Val Trp Tyr 
145                 150                 155                 160 


Asn Phe Phe Arg Ala Trp Asn Gly Gly Phe Ser Gly Asn Leu Glu Gly 
                165                 170                 175     


Glu Gly Phe Ile Leu Gly Gly Val Phe Val Val Gly Ser Gly Lys Gln 
            180                 185                 190         


Gly Ile Leu Leu Glu His Arg Glu Lys Glu Phe Gly Asp Lys Val Asn 
        195                 200                 205             


Leu Leu Ser Val Leu Glu Ala Ala Lys Met Ile Lys Pro Gln Thr Leu 
    210                 215                 220                 


Ala Ser Glu Lys Lys 
225                 


<210>  5078
<211>  425
<212>  PRT
<213>  Homo Sapiens

<400>  5078

Met Met Pro Ser Glu Ser Gly Ala Glu Arg Arg Asp Arg Ala Ala Ala 
1               5                   10                  15      


Gln Val Gly Thr Ala Ala Ala Thr Ala Val Ala Thr Ala Ala Pro Ala 
            20                  25                  30          


Gly Gly Gly Pro Asp Pro Glu Ala Leu Ser Ala Phe Pro Gly Arg His 
        35                  40                  45              


Leu Ser Gly Leu Ser Trp Pro Gln Val Lys Arg Leu Asp Ala Leu Leu 
    50                  55                  60                  


Ser Glu Pro Ile Pro Ile His Gly Arg Gly Asn Phe Pro Thr Leu Ser 
65                  70                  75                  80  


Val Gln Pro Arg Gln Ile Val Gln Val Val Arg Ser Thr Leu Glu Glu 
                85                  90                  95      


Gln Gly Leu His Val His Ser Val Arg Leu His Gly Ser Ala Ala Ser 
            100                 105                 110         


His Val Leu His Pro Glu Ser Gly Leu Gly Tyr Lys Asp Leu Asp Leu 
        115                 120                 125             


Val Phe Arg Val Asp Leu Arg Ser Glu Ala Ser Phe Gln Leu Thr Lys 
    130                 135                 140                 


Ala Val Val Leu Ala Cys Leu Leu Asp Phe Leu Pro Ala Gly Val Ser 
145                 150                 155                 160 


Arg Ala Lys Ile Thr Pro Leu Thr Leu Lys Glu Ala Tyr Val Gln Lys 
                165                 170                 175     


Leu Val Lys Val Cys Thr Asp Ser Asp Arg Trp Ser Leu Ile Ser Leu 
            180                 185                 190         


Ser Asn Lys Ser Gly Lys Asn Val Glu Leu Lys Phe Val Asp Ser Val 
        195                 200                 205             


Arg Arg Gln Phe Glu Phe Ser Ile Asp Ser Phe Gln Ile Ile Leu Asp 
    210                 215                 220                 


Ser Leu Leu Leu Phe Gly Gln Cys Ser Ser Thr Pro Met Ser Glu Ala 
225                 230                 235                 240 


Phe His Pro Thr Val Thr Gly Glu Ser Leu Tyr Gly Asp Phe Thr Glu 
                245                 250                 255     


Ala Leu Glu His Leu Arg His Arg Val Ile Ala Thr Arg Ser Pro Glu 
            260                 265                 270         


Glu Ile Arg Gly Gly Gly Leu Leu Lys Tyr Cys His Leu Leu Val Arg 
        275                 280                 285             


Gly Phe Arg Pro Arg Pro Ser Thr Asp Val Arg Ala Leu Gln Arg Tyr 
    290                 295                 300                 


Met Cys Ser Arg Phe Phe Ile Asp Phe Pro Asp Leu Val Glu Gln Arg 
305                 310                 315                 320 


Arg Thr Leu Glu Arg Tyr Leu Glu Ala His Phe Gly Gly Ala Asp Ala 
                325                 330                 335     


Ala Arg Arg Tyr Ala Cys Leu Val Thr Leu His Arg Val Val Asn Glu 
            340                 345                 350         


Ser Thr Val Cys Leu Met Asn His Glu Arg Arg Gln Thr Leu Asp Leu 
        355                 360                 365             


Ile Ala Ala Leu Ala Leu Gln Ala Leu Ala Glu Gln Gly Pro Ala Ala 
    370                 375                 380                 


Thr Ala Ala Leu Ala Trp Arg Pro Pro Gly Thr Asp Gly Val Val Pro 
385                 390                 395                 400 


Ala Thr Val Asn Tyr Tyr Val Thr Pro Val Gln Pro Leu Leu Ala His 
                405                 410                 415     


Ala Tyr Pro Thr Trp Leu Pro Cys Asn 
            420                 425 


<210>  5079
<211>  113
<212>  PRT
<213>  Homo Sapiens

<400>  5079

Met Ile Ser Thr Arg Tyr Arg Arg Arg Arg Asp Ala Pro Arg Gly Pro 
1               5                   10                  15      


Gly Arg Cys Pro Pro His Pro Thr Arg Pro Arg Gly Pro Gly Arg Lys 
            20                  25                  30          


Arg Gly Ala Ala Gly Ser Pro Gly Ala Ala Pro Ser Ala Ser Arg Arg 
        35                  40                  45              


Pro Glu Phe Pro Lys Pro Leu Arg Val Leu Pro Trp Arg Glu Arg Gly 
    50                  55                  60                  


Arg Gly Gly Arg Glu Trp Pro Met Ser Leu Arg Ser Pro Leu Pro Thr 
65                  70                  75                  80  


Ser Ala Cys Gly Trp Gly Glu Ser Gly Arg Arg Ala Gly Pro Gly Ser 
                85                  90                  95      


Leu Arg Ser Ser Asp Arg Thr Glu Arg Ala Arg Cys Ser Leu Arg Pro 
            100                 105                 110         


Arg 
    


<210>  5080
<211>  225
<212>  PRT
<213>  Homo Sapiens

<400>  5080

Met Leu Leu Thr Leu Ala Gly Gly Ala Leu Phe Phe Pro Gly Leu Phe 
1               5                   10                  15      


Ala Leu Cys Thr Trp Ala Leu Arg Arg Ser Gln Pro Gly Trp Ser Arg 
            20                  25                  30          


Thr Asp Cys Val Met Ile Ser Thr Arg Leu Val Ser Ser Val His Ala 
        35                  40                  45              


Val Leu Ala Thr Gly Ser Gly Ile Val Ile Ile Arg Ser Cys Asp Asp 
    50                  55                  60                  


Val Ile Thr Gly Arg His Trp Leu Ala Arg Glu Tyr Val Trp Phe Leu 
65                  70                  75                  80  


Ile Pro Tyr Met Ile Tyr Asp Ser Tyr Ala Met Tyr Leu Cys Glu Trp 
                85                  90                  95      


Cys Arg Thr Arg Asp Gln Asn Arg Ala Pro Ser Leu Thr Leu Arg Asn 
            100                 105                 110         


Phe Leu Ser Arg Asn Arg Leu Met Ile Thr His His Ala Val Ile Leu 
        115                 120                 125             


Phe Val Leu Val Pro Val Ala Gln Leu Lys Gln Gln His Thr Leu Leu 
    130                 135                 140                 


Tyr Lys Val Asn Gly Ile Leu Thr Leu Ala Thr Phe Leu Ser Cys Arg 
145                 150                 155                 160 


Ile Leu Leu Phe Pro Phe Met Tyr Trp Ser Tyr Gly Arg Gln Gln Gly 
                165                 170                 175     


Leu Ser Leu Leu Gln Val Pro Phe Ser Ile Pro Phe Tyr Cys Asn Val 
            180                 185                 190         


Ala Asn Ala Phe Leu Val Ala Pro Gln Ile Tyr Trp Phe Cys Leu Leu 
        195                 200                 205             


Cys Arg Lys Ala Val Arg Leu Phe Asp Thr Pro Gln Ala Lys Lys Asp 
    210                 215                 220                 


Gly 
225 


<210>  5081
<211>  257
<212>  PRT
<213>  Homo Sapiens

<400>  5081

Met Leu Leu Thr Leu Ala Gly Gly Ala Leu Phe Phe Pro Gly Leu Phe 
1               5                   10                  15      


Ala Leu Cys Thr Trp Ala Leu Arg Arg Ser Gln Pro Gly Trp Ser Arg 
            20                  25                  30          


Thr Asp Cys Val Met Ile Ser Thr Arg Leu Val Ser Ser Val His Ala 
        35                  40                  45              


Val Leu Ala Thr Gly Ser Gly Ile Val Ile Ile Arg Ser Cys Asp Asp 
    50                  55                  60                  


Val Ile Thr Gly Arg His Trp Leu Ala Arg Glu Tyr Val Trp Phe Leu 
65                  70                  75                  80  


Ile Pro Tyr Met Ile Tyr Asp Ser Tyr Ala Met Tyr Leu Cys Glu Trp 
                85                  90                  95      


Cys Arg Thr Arg Asp Gln Asn Arg Ala Pro Ser Leu Thr Leu Arg Asn 
            100                 105                 110         


Phe Leu Ser Arg Asn Arg Leu Met Ile Thr His His Ala Val Ile Leu 
        115                 120                 125             


Phe Val Leu Val Pro Val Ala Gln Arg Leu Arg Gly Asp Leu Gly Asp 
    130                 135                 140                 


Phe Phe Val Gly Cys Ile Phe Thr Ala Glu Leu Ser Thr Pro Phe Val 
145                 150                 155                 160 


Ser Leu Gly Arg Val Leu Ile Gln Leu Lys Gln Gln His Thr Leu Leu 
                165                 170                 175     


Tyr Lys Val Asn Gly Ile Leu Thr Leu Ala Thr Phe Leu Ser Cys Arg 
            180                 185                 190         


Ile Leu Leu Phe Pro Phe Met Tyr Trp Ser Tyr Gly Arg Gln Gln Gly 
        195                 200                 205             


Leu Ser Leu Leu Gln Val Pro Phe Ser Ile Pro Phe Tyr Cys Asn Val 
    210                 215                 220                 


Ala Asn Ala Phe Leu Val Ala Pro Gln Ile Tyr Trp Phe Cys Leu Leu 
225                 230                 235                 240 


Cys Arg Lys Ala Val Arg Leu Phe Asp Thr Pro Gln Ala Lys Lys Asp 
                245                 250                 255     


Gly 
    


<210>  5082
<211>  69
<212>  PRT
<213>  Homo Sapiens

<400>  5082

Met Leu Leu Thr Leu Ala Gly Gly Ala Leu Phe Phe Pro Gly Leu Phe 
1               5                   10                  15      


Ala Leu Cys Thr Trp Ala Leu Arg Arg Ser Gln Pro Gly Trp Ser Arg 
            20                  25                  30          


Thr Asp Cys Val Met Ile Ser Thr Arg Leu Val Ser Ser Val His Ala 
        35                  40                  45              


Val Leu Ala Thr Gly Ser Gly Ile Val Ile Ile Arg Ser Cys Asp Asp 
    50                  55                  60                  


Val Ile Thr Gly Ser 
65                  


<210>  5083
<211>  149
<212>  PRT
<213>  Homo Sapiens

<400>  5083

Met Leu Leu Thr Leu Ala Gly Gly Ala Leu Phe Phe Pro Gly Leu Phe 
1               5                   10                  15      


Ala Leu Cys Thr Trp Ala Leu Arg Arg Ser Gln Pro Gly Trp Ser Arg 
            20                  25                  30          


Thr Asp Cys Val Met Ile Ser Thr Arg Tyr Arg Arg Arg Arg Asp Ala 
        35                  40                  45              


Pro Arg Gly Pro Gly Arg Cys Pro Pro His Pro Thr Arg Pro Arg Gly 
    50                  55                  60                  


Pro Gly Arg Lys Arg Gly Ala Ala Gly Ser Pro Gly Ala Ala Pro Ser 
65                  70                  75                  80  


Ala Ser Arg Arg Pro Glu Phe Pro Lys Pro Leu Arg Val Leu Pro Trp 
                85                  90                  95      


Arg Glu Arg Gly Arg Gly Gly Arg Glu Trp Pro Met Ser Leu Arg Ser 
            100                 105                 110         


Pro Leu Pro Thr Ser Ala Cys Gly Trp Gly Glu Ser Gly Arg Arg Ala 
        115                 120                 125             


Gly Pro Gly Ser Leu Arg Ser Ser Asp Arg Thr Glu Arg Ala Arg Cys 
    130                 135                 140                 


Ser Leu Arg Pro Arg 
145                 


<210>  5084
<211>  38
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5084

Xaa Ala Thr Gly Ser Gly Ile Val Ile Ile Arg Ser Cys Asp Asp Val 
1               5                   10                  15      


Ile Thr Gly Arg Gly Ser Gly Glu Thr Leu Gly Thr Ser Leu Ser Ala 
            20                  25                  30          


Ala Ser Ser Arg Gln Asn 
        35              


<210>  5085
<211>  252
<212>  PRT
<213>  Homo Sapiens

<400>  5085

Gly Gln Gly Ile Ala Ala Ala Leu Ile His Leu Pro Ser Thr Gly Asn 
1               5                   10                  15      


Lys His Trp Arg Pro Arg Ser Pro Glu Ala Ser Thr Asp Cys Cys Trp 
            20                  25                  30          


Leu His Gln Ala Thr Gly Ser Gly Ser Val Thr Gln Ala Gly Val Gln 
        35                  40                  45              


Trp Tyr Asp Leu Gly Ser Leu Gln Pro Leu Pro Pro Arg Phe Lys Arg 
    50                  55                  60                  


Phe Ser Cys Leu Ser Leu Pro Ser Ser Trp Asp Tyr Arg Ser Ser Trp 
65                  70                  75                  80  


Glu Leu Pro Asp Leu Gln Glu Gly Lys Ile Gln Ala Ile Ser Asp Ser 
                85                  90                  95      


Asp Gly Val Asn Tyr Pro Trp Tyr Gly Asn Thr Thr Glu Thr Cys Thr 
            100                 105                 110         


Ile Val Gly Pro Thr Lys Arg Asp Ser Lys Phe Ile Ile Ser Met Asn 
        115                 120                 125             


Asp Asn Phe Tyr Pro Ser Val Thr Trp Ala Val Pro Val Ser Glu Ser 
    130                 135                 140                 


Asn Val Ala Lys Leu Thr Asn Ile Tyr Arg Asp Gln Ser Phe Thr Thr 
145                 150                 155                 160 


Trp Leu Val Ala Thr Asn Thr Ser Thr Asn Asp Met Ile Ile Leu Gln 
                165                 170                 175     


Thr Leu His Trp Arg Met Gln Leu Ser Ile Glu Val Asn Pro Asn Arg 
            180                 185                 190         


Pro Leu Gly Gln Arg Ala Arg Leu Arg Glu Pro Ile Ala Gln Asp Gln 
        195                 200                 205             


Pro Lys Ile Leu Ser Lys Asn Glu Pro Ile Pro Pro Ser Ala Leu Val 
    210                 215                 220                 


Lys Pro Asn Ala Asn Asp Ala Gln Val Leu Met Trp Arg Pro Lys Tyr 
225                 230                 235                 240 


Gly Gln Pro Leu Val Val Ile Pro Pro Lys His Arg 
                245                 250         


<210>  5086
<211>  283
<212>  PRT
<213>  Homo Sapiens

<400>  5086

Met Pro Gly Phe Phe Cys Asp Cys Trp Pro Ser Leu Glu Ile Arg Ala 
1               5                   10                  15      


Leu Leu Tyr Ala Met Gly Cys Ile Gln Ser Ile Gly Gly Lys Ala Arg 
            20                  25                  30          


Val Phe Arg Glu Gly Ile Thr Val Ile Asp Val Lys Ala Ser Ile Asp 
        35                  40                  45              


Pro Val Pro Thr Ser Ile Asp Glu Ser Ser Ser Val Val Leu Arg Tyr 
    50                  55                  60                  


Arg Thr Pro His Phe Arg Ala Ser Ala Gln Val Val Met Pro Pro Ile 
65                  70                  75                  80  


Pro Lys Lys Glu Thr Trp Val Val Gly Trp Ile Gln Ala Cys Ser His 
                85                  90                  95      


Met Glu Phe Tyr Asn Gln Tyr Gly Glu Gln Gly Met Ser Ser Trp Glu 
            100                 105                 110         


Leu Pro Asp Leu Gln Glu Gly Lys Ile Gln Ala Ile Ser Asp Ser Asp 
        115                 120                 125             


Gly Val Asn Tyr Pro Trp Tyr Gly Asn Thr Thr Glu Thr Cys Thr Ile 
    130                 135                 140                 


Val Gly Pro Thr Lys Arg Asp Ser Lys Phe Ile Ile Ser Met Asn Asp 
145                 150                 155                 160 


Asn Phe Tyr Pro Ser Val Thr Trp Ala Val Pro Val Ser Glu Ser Asn 
                165                 170                 175     


Val Ala Lys Leu Thr Asn Ile Tyr Arg Asp Gln Ser Phe Thr Thr Trp 
            180                 185                 190         


Leu Val Ala Thr Asn Thr Ser Thr Asn Asp Met Ile Ile Leu Gln Thr 
        195                 200                 205             


Leu His Trp Arg Met Gln Leu Ser Ile Glu Val Asn Pro Asn Arg Pro 
    210                 215                 220                 


Leu Gly Gln Arg Ala Arg Leu Arg Glu Pro Ile Ala Gln Asp Gln Pro 
225                 230                 235                 240 


Lys Ile Leu Ser Lys Asn Glu Pro Ile Pro Pro Ser Ala Leu Val Lys 
                245                 250                 255     


Pro Asn Ala Asn Asp Ala Gln Val Leu Met Trp Arg Pro Lys Tyr Gly 
            260                 265                 270         


Gln Pro Leu Val Val Ile Pro Pro Lys His Arg 
        275                 280             


<210>  5087
<211>  280
<212>  PRT
<213>  Homo Sapiens

<400>  5087

Met Thr Ser Tyr Ile Leu Ile Ser Phe Val Leu Leu Ile Gly Val Gly 
1               5                   10                  15      


Cys Ile Glu Lys Asp Gln Ser Cys Pro Val Phe Gly Gly Arg Lys Arg 
            20                  25                  30          


Leu His Leu Leu Phe Val Gly Gly Gln Leu Arg Gln Val Arg Met Leu 
        35                  40                  45              


Arg Gly Ser Pro Glu Ala Ser Thr Asp Cys Cys Trp Leu His Gln Ala 
    50                  55                  60                  


Thr Gly Ser Gly Ser Val Thr Gln Ala Gly Val Gln Trp Tyr Asp Leu 
65                  70                  75                  80  


Gly Ser Leu Gln Pro Leu Pro Pro Arg Phe Lys Arg Phe Ser Cys Leu 
                85                  90                  95      


Ser Leu Pro Ser Ser Trp Asp Tyr Arg Ser Ser Trp Glu Leu Pro Asp 
            100                 105                 110         


Leu Gln Glu Gly Lys Ile Gln Ala Ile Ser Asp Ser Asp Gly Val Asn 
        115                 120                 125             


Tyr Pro Trp Tyr Gly Asn Thr Thr Glu Thr Cys Thr Ile Val Gly Pro 
    130                 135                 140                 


Thr Lys Arg Asp Ser Lys Phe Ile Ile Ser Met Asn Asp Asn Phe Tyr 
145                 150                 155                 160 


Pro Ser Val Thr Trp Ala Val Pro Val Ser Glu Ser Asn Val Ala Lys 
                165                 170                 175     


Leu Thr Asn Ile Tyr Arg Asp Gln Ser Phe Thr Thr Trp Leu Val Ala 
            180                 185                 190         


Thr Asn Thr Ser Thr Asn Asp Met Ile Ile Leu Gln Thr Leu His Trp 
        195                 200                 205             


Arg Met Gln Leu Ser Ile Glu Val Asn Pro Asn Arg Pro Leu Gly Gln 
    210                 215                 220                 


Arg Ala Arg Leu Arg Glu Pro Ile Ala Gln Asp Gln Pro Lys Ile Leu 
225                 230                 235                 240 


Ser Lys Asn Glu Pro Ile Pro Pro Ser Ala Leu Val Lys Pro Asn Ala 
                245                 250                 255     


Asn Asp Ala Gln Val Leu Met Trp Arg Pro Lys Tyr Gly Gln Pro Leu 
            260                 265                 270         


Val Val Ile Pro Pro Lys His Arg 
        275                 280 


<210>  5088
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  5088

Met Gln Arg Val Ser Gly Leu Leu Ser Trp Thr Leu Ser Arg Val Leu 
1               5                   10                  15      


Trp Leu Ser Gly Leu Ser Glu Pro Gly Ala Ala Arg Gln Pro Arg Ile 
            20                  25                  30          


Met Glu Glu Lys Ala Leu Glu Val Tyr Asp Leu Ile Arg Thr Ile Arg 
        35                  40                  45              


Asp Pro Glu Lys Pro Asn Thr Leu Glu Glu Leu Glu Val Val Ser Glu 
    50                  55                  60                  


Ser Cys Val Glu Val Gln Glu Ile Asn Glu Glu Glu Tyr Leu Val Ile 
65                  70                  75                  80  


Ile Arg Phe Thr Pro Thr Val Pro His Cys Ser Leu Ala Thr Leu Ile 
                85                  90                  95      


Gly Leu Cys Leu Arg Val Lys Leu Gln Arg Cys Leu Pro Phe Lys His 
            100                 105                 110         


Lys Leu Glu Ile Tyr Ile Ser Glu Gly Thr His Ser Thr Glu Glu Asp 
        115                 120                 125             


Ile Asn Lys Gln Ile Asn Asp Lys Glu Arg Val Ala Ala Ala Met Glu 
    130                 135                 140                 


Asn Pro Asn Leu Arg Glu Ile Val Glu Gln Cys Val Leu Glu Pro Asp 
145                 150                 155                 160 


<210>  5089
<211>  130
<212>  PRT
<213>  Homo Sapiens

<400>  5089

Met Gln Arg Val Ser Gly Leu Leu Ser Trp Thr Leu Ser Arg Val Leu 
1               5                   10                  15      


Trp Leu Ser Gly Leu Ser Glu Pro Gly Ala Ala Arg Gln Pro Arg Ile 
            20                  25                  30          


Met Glu Glu Lys Ala Leu Glu Val Tyr Asp Leu Ile Arg Thr Ile Arg 
        35                  40                  45              


Asp Pro Glu Lys Pro Asn Thr Leu Glu Glu Leu Glu Val Val Ser Glu 
    50                  55                  60                  


Ser Cys Val Glu Val Gln Glu Ile Asn Glu Glu Glu Tyr Leu Val Ile 
65                  70                  75                  80  


Ile Arg Phe Thr Pro Thr Val Pro His Cys Ser Leu Ala Thr Leu Ile 
                85                  90                  95      


Gly Leu Cys Leu Arg Val Lys Leu Gln Arg Cys Leu Pro Phe Lys His 
            100                 105                 110         


Lys Leu Glu Ile Tyr Ile Ser Glu Gly Thr His Ser Thr Glu Glu Asp 
        115                 120                 125             


Ser Lys 
    130 


<210>  5090
<211>  102
<212>  PRT
<213>  Homo Sapiens

<400>  5090

Met Gln Arg Val Ser Gly Leu Leu Ser Trp Thr Leu Ser Arg Val Leu 
1               5                   10                  15      


Trp Leu Ser Gly Leu Ser Glu Pro Gly Ala Ala Arg Gln Pro Arg Ile 
            20                  25                  30          


Met Glu Glu Lys Ala Leu Glu Val Tyr Asp Leu Ile Arg Thr Ile Arg 
        35                  40                  45              


Asp Pro Glu Lys Pro Asn Thr Leu Glu Glu Leu Glu Val Val Ser Glu 
    50                  55                  60                  


Ser Cys Val Glu Val Gln Glu Ile Asn Glu Glu Glu Tyr Leu Val Ile 
65                  70                  75                  80  


Ile Arg Phe Thr Pro Thr Val Pro His Cys Ser Leu Ala Thr Leu Ile 
                85                  90                  95      


Val Gly Asn Leu His Phe 
            100         


<210>  5091
<211>  102
<212>  PRT
<213>  Homo Sapiens

<400>  5091

Met Gln Arg Val Ser Gly Leu Leu Ser Trp Thr Leu Ser Arg Val Leu 
1               5                   10                  15      


Trp Leu Ser Gly Leu Ser Glu Pro Gly Ala Ala Arg Gln Pro Arg Ile 
            20                  25                  30          


Met Glu Glu Lys Ala Leu Glu Val Tyr Asp Leu Ile Arg Thr Ile Arg 
        35                  40                  45              


Asp Pro Glu Lys Pro Asn Thr Leu Glu Glu Leu Glu Val Val Ser Glu 
    50                  55                  60                  


Ser Cys Val Glu Val Gln Glu Ile Asn Glu Glu Glu Tyr Leu Val Ile 
65                  70                  75                  80  


Ile Arg Phe Thr Pro Thr Val Pro His Cys Ser Leu Ala Thr Leu Ile 
                85                  90                  95      


Val Gly Asn Leu His Phe 
            100         


<210>  5092
<211>  69
<212>  PRT
<213>  Homo Sapiens

<400>  5092

Met Gln Arg Val Ser Gly Leu Leu Ser Trp Thr Leu Ser Arg Val Leu 
1               5                   10                  15      


Trp Leu Ser Gly Leu Ser Glu Pro Gly Ala Ala Arg Gln Pro Arg Ile 
            20                  25                  30          


Met Glu Glu Lys Ala Leu Glu Val Tyr Gly Trp Asn Ala Met Ala Gly 
        35                  40                  45              


Ser Arg Leu Thr Ala Thr Ser Ala Phe Trp Phe Gln Val Ile Leu Leu 
    50                  55                  60                  


Pro Gln Ser Pro Lys 
65                  


<210>  5093
<211>  186
<212>  PRT
<213>  Homo Sapiens

<400>  5093

Met Ala Ala Trp Gly Lys Lys His Ala Gly Lys Asp Pro Val Arg Asp 
1               5                   10                  15      


Glu Cys Glu Glu Arg Asn Arg Phe Thr Glu Thr Arg Glu Glu Asp Val 
            20                  25                  30          


Thr Asp Glu His Gly Glu Arg Glu Pro Phe Ala Glu Thr Asp Glu His 
        35                  40                  45              


Thr Gly Ala Asn Thr Lys Lys Pro Glu Asp Thr Ala Glu Asp Leu Thr 
    50                  55                  60                  


Ala Lys Arg Lys Arg Met Lys Met Asp Lys Thr Cys Ser Lys Thr Lys 
65                  70                  75                  80  


Asn Lys Ser Lys His Ala Leu Arg Lys Lys Gln Leu Lys Arg Gln Lys 
                85                  90                  95      


Arg Asp Tyr Ile His Ser Leu Lys Leu Leu Asn Val Leu Glu Glu Tyr 
            100                 105                 110         


Ile Thr Asp Glu Gln Lys Glu Glu Glu Glu Glu Glu Gly Glu Glu Glu 
        115                 120                 125             


Glu Leu Ile Arg Ile Phe Gln Glu Gln Gln Lys Lys Trp Gln Gln Tyr 
    130                 135                 140                 


Arg Ser Val Arg Arg Glu Arg Leu Lys Glu Met Lys Leu Leu Arg Asp 
145                 150                 155                 160 


Gln Phe Val Lys Ala Leu Glu Asp Phe Glu Asp Leu Cys Asp Arg Val 
                165                 170                 175     


Phe Ser Asp Glu Asp Ser Glu Leu Asp Asn 
            180                 185     


<210>  5094
<211>  186
<212>  PRT
<213>  Homo Sapiens

<400>  5094

Met Ala Ala Trp Gly Lys Lys His Ala Gly Lys Asp Pro Val Arg Asp 
1               5                   10                  15      


Glu Cys Glu Glu Arg Asn Arg Phe Thr Glu Thr Arg Glu Glu Asp Val 
            20                  25                  30          


Thr Asp Glu His Gly Glu Arg Glu Pro Phe Ala Glu Thr Asp Glu His 
        35                  40                  45              


Thr Gly Ala Asn Thr Lys Lys Pro Glu Asp Thr Ala Glu Asp Leu Thr 
    50                  55                  60                  


Ala Lys Arg Lys Arg Met Lys Met Asp Lys Thr Cys Ser Lys Thr Lys 
65                  70                  75                  80  


Asn Lys Ser Lys His Ala Leu Arg Lys Lys Gln Leu Lys Arg Gln Lys 
                85                  90                  95      


Arg Asp Tyr Ile His Ser Leu Lys Leu Leu Asn Val Leu Glu Glu Tyr 
            100                 105                 110         


Ile Thr Asp Glu Gln Lys Glu Glu Glu Glu Glu Glu Gly Glu Glu Glu 
        115                 120                 125             


Glu Leu Ile Arg Ile Phe Gln Glu Gln Gln Lys Lys Trp Gln Gln Tyr 
    130                 135                 140                 


Arg Ser Val Arg Arg Glu Arg Leu Lys Glu Met Lys Leu Leu Arg Asp 
145                 150                 155                 160 


Gln Phe Val Lys Ala Leu Glu Asp Phe Glu Asp Leu Cys Asp Arg Val 
                165                 170                 175     


Phe Ser Asp Glu Asp Ser Glu Leu Asp Asn 
            180                 185     


<210>  5095
<211>  90
<212>  PRT
<213>  Homo Sapiens

<400>  5095

Met Lys Ala Lys Lys Ala His Pro Arg Val Glu Tyr Asn Lys Thr Ser 
1               5                   10                  15      


Gly Asn Ala Phe Glu Glu Gln Phe Ser Leu Pro Thr Lys Val Arg Gly 
            20                  25                  30          


Ser Pro Leu Ala Ser Gln Asp Asn Gln Pro Arg Ile Leu Trp Ala Gly 
        35                  40                  45              


Gly Leu Pro Arg Pro Ser Trp Arg Leu Asn Leu Trp Arg Pro Gly Gly 
    50                  55                  60                  


Arg Ser Met Gln Glu Arg Ile Gln Ser Val Met Asn Val Arg Lys Glu 
65                  70                  75                  80  


Thr Val Leu Gln Lys Gln Gly Arg Lys Met 
                85                  90  


<210>  5096
<211>  226
<212>  PRT
<213>  Homo Sapiens

<400>  5096

Met Pro Gly Phe Leu Ser Phe Leu Ser Val Ser Leu Arg Ser Pro Gly 
1               5                   10                  15      


Ser Gly Ile Ala Ser Ser Phe Pro Gly Gln Pro Ala Thr Asp Pro Val 
            20                  25                  30          


Gly Arg Arg Ala Ala Lys Ala Gln Leu Glu Ala Gln Phe Met Ala Ala 
        35                  40                  45              


Trp Gly Lys Lys His Ala Gly Lys Asp Pro Val Arg Asp Glu Cys Glu 
    50                  55                  60                  


Glu Arg Asn Arg Phe Thr Glu Thr Arg Glu Glu Asp Val Thr Asp Glu 
65                  70                  75                  80  


His Gly Glu Arg Glu Pro Phe Ala Glu Thr Asp Glu His Thr Gly Ala 
                85                  90                  95      


Asn Thr Lys Lys Pro Glu Asp Thr Ala Val Gly Ala Asn Asn Phe Lys 
            100                 105                 110         


Asn Tyr Pro Val His Ile Gly Val Ser Ser Glu Gln His Ile Leu Leu 
        115                 120                 125             


Asp Cys Ser Leu Ser Arg Gln Lys Arg Asp Tyr Ile His Ser Leu Lys 
    130                 135                 140                 


Leu Leu Asn Val Leu Glu Glu Tyr Ile Thr Asp Glu Gln Lys Glu Glu 
145                 150                 155                 160 


Glu Glu Glu Glu Gly Glu Glu Glu Glu Leu Ile Arg Ile Phe Gln Glu 
                165                 170                 175     


Gln Gln Lys Lys Trp Gln Gln Tyr Arg Ser Val Arg Arg Glu Arg Leu 
            180                 185                 190         


Lys Glu Met Lys Leu Leu Arg Asp Gln Phe Val Lys Ala Leu Glu Asp 
        195                 200                 205             


Phe Glu Asp Leu Cys Asp Arg Val Phe Ser Asp Glu Asp Ser Glu Leu 
    210                 215                 220                 


Asp Asn 
225     


<210>  5097
<211>  25
<212>  PRT
<213>  Homo Sapiens

<400>  5097

Lys Glu Arg Cys Gln Tyr Tyr Thr Ala Ser Phe Ser Asp Tyr Ala Lys 
1               5                   10                  15      


Tyr Tyr Ala Leu Val Cys Tyr Gly Glu 
            20                  25  


<210>  5098
<211>  155
<212>  PRT
<213>  Homo Sapiens

<400>  5098

Met Cys Ile Val Leu Arg Pro Ser Arg Val His Asn Ser Glu Glu Asn 
1               5                   10                  15      


Thr Met Arg Ala Leu Thr Leu Lys Asp Ile Leu Asn Gly Thr Phe Ser 
            20                  25                  30          


Tyr Lys Thr Phe Phe Pro Asn Trp Ile Ser Gly Gln Glu Tyr Leu His 
        35                  40                  45              


Gln Ser Ala Asp Asn Asn Ile Val Leu Tyr Asn Ile Glu Thr Gly Gln 
    50                  55                  60                  


Ser Tyr Thr Ile Leu Ser Asn Arg Thr Met Lys Ser Val Asn Ala Ser 
65                  70                  75                  80  


Asn Tyr Gly Leu Ser Pro Asp Arg Gln Phe Val Tyr Leu Glu Ser Asp 
                85                  90                  95      


Tyr Ser Lys Leu Trp Arg Tyr Ser Tyr Thr Ala Thr Tyr Tyr Ile Tyr 
            100                 105                 110         


Asp Leu Ser Asn Gly Glu Phe Val Arg Gly Asn Glu Leu Pro Arg Pro 
        115                 120                 125             


Ile Gln Tyr Leu Cys Trp Ser Pro Val Gly Ser Lys Leu Ala Tyr Val 
    130                 135                 140                 


Tyr Gln Asn Asn Ile Tyr Leu Lys Gln Arg Pro 
145                 150                 155 


<210>  5099
<211>  121
<212>  PRT
<213>  Homo Sapiens

<400>  5099

Met Cys Ile Val Leu Arg Pro Ser Arg Val His Asn Ser Glu Glu Asn 
1               5                   10                  15      


Thr Met Arg Ala Leu Thr Leu Lys Asp Ile Leu Asn Gly Thr Phe Ser 
            20                  25                  30          


Tyr Lys Thr Phe Phe Pro Asn Trp Ile Ser Gly Gln Glu Tyr Leu His 
        35                  40                  45              


Gln Ser Ala Asp Asn Asn Ile Val Leu Tyr Asn Ile Glu Thr Gly Gln 
    50                  55                  60                  


Ser Tyr Thr Ile Leu Ser Asn Arg Thr Met Lys Ser Val Asn Ala Ser 
65                  70                  75                  80  


Asn Tyr Gly Leu Ser Pro Asp Arg Gln Phe Val Tyr Leu Glu Ser Asp 
                85                  90                  95      


Tyr Ser Lys Leu Trp Arg Tyr Ser Tyr Thr Ala Thr Tyr Tyr Ile Tyr 
            100                 105                 110         


Asp Leu Ser Asn Gly Lys Trp Gln Leu 
        115                 120     


<210>  5100
<211>  760
<212>  PRT
<213>  Homo Sapiens

<400>  5100

Met Lys Thr Trp Val Lys Ile Val Phe Gly Val Ala Thr Ser Ala Val 
1               5                   10                  15      


Leu Ala Leu Leu Val Met Cys Ile Val Leu Arg Pro Ser Arg Val His 
            20                  25                  30          


Asn Ser Glu Glu Asn Thr Met Arg Ala Leu Thr Leu Lys Asp Ile Leu 
        35                  40                  45              


Asn Gly Thr Phe Ser Tyr Lys Thr Phe Phe Pro Asn Trp Ile Ser Gly 
    50                  55                  60                  


Gln Glu Tyr Leu His Gln Ser Ala Asp Asn Asn Ile Val Leu Tyr Asn 
65                  70                  75                  80  


Ile Glu Thr Gly Gln Ser Tyr Thr Ile Leu Ser Asn Arg Thr Met Lys 
                85                  90                  95      


Ser Val Asn Ala Ser Asn Tyr Gly Leu Ser Pro Asp Arg Gln Phe Val 
            100                 105                 110         


Tyr Leu Glu Ser Asp Tyr Ser Lys Leu Trp Arg Tyr Ser Tyr Thr Ala 
        115                 120                 125             


Thr Tyr Tyr Ile Tyr Asp Leu Ser Asn Gly Glu Phe Val Arg Gly Asn 
    130                 135                 140                 


Glu Leu Pro Arg Pro Ile Gln Tyr Leu Cys Trp Ser Pro Val Gly Ser 
145                 150                 155                 160 


Lys Leu Ala Tyr Val Tyr Gln Asn Asn Ile Tyr Leu Lys Gln Arg Pro 
                165                 170                 175     


Gly Asp Pro Pro Phe Gln Ile Thr Phe Asn Gly Arg Glu Asn Lys Ile 
            180                 185                 190         


Phe Asn Gly Ile Pro Asp Trp Val Tyr Glu Glu Glu Met Leu Ala Thr 
        195                 200                 205             


Lys Tyr Ala Leu Trp Trp Ser Pro Asn Gly Lys Phe Leu Ala Tyr Ala 
    210                 215                 220                 


Glu Phe Asn Asp Thr Asp Ile Pro Val Ile Ala Tyr Ser Tyr Tyr Gly 
225                 230                 235                 240 


Asp Glu Gln Tyr Pro Arg Thr Ile Asn Ile Pro Tyr Pro Lys Ala Gly 
                245                 250                 255     


Ala Lys Asn Pro Val Val Arg Ile Phe Ile Ile Asp Thr Thr Tyr Pro 
            260                 265                 270         


Ala Tyr Val Gly Pro Gln Glu Val Pro Val Pro Ala Met Ile Ala Ser 
        275                 280                 285             


Ser Asp Tyr Tyr Phe Ser Trp Leu Thr Trp Val Thr Asp Glu Arg Val 
    290                 295                 300                 


Cys Leu Gln Trp Leu Lys Arg Val Gln Asn Val Ser Val Leu Ser Ile 
305                 310                 315                 320 


Cys Asp Phe Arg Glu Asp Trp Gln Thr Trp Asp Cys Pro Lys Thr Gln 
                325                 330                 335     


Glu His Ile Glu Glu Ser Arg Thr Gly Trp Ala Gly Gly Phe Phe Val 
            340                 345                 350         


Ser Thr Pro Val Phe Ser Tyr Asp Ala Ile Ser Tyr Tyr Lys Ile Phe 
        355                 360                 365             


Ser Asp Lys Asp Gly Tyr Lys His Ile His Tyr Ile Lys Asp Thr Val 
    370                 375                 380                 


Glu Asn Ala Ile Gln Ile Thr Ser Gly Lys Trp Glu Ala Ile Asn Ile 
385                 390                 395                 400 


Phe Arg Val Thr Gln Asp Ser Leu Phe Tyr Ser Ser Asn Glu Phe Glu 
                405                 410                 415     


Glu Tyr Pro Gly Arg Arg Asn Ile Tyr Arg Ile Ser Ile Gly Ser Tyr 
            420                 425                 430         


Pro Pro Ser Lys Lys Cys Val Thr Cys His Leu Arg Lys Glu Arg Cys 
        435                 440                 445             


Gln Tyr Tyr Thr Ala Ser Phe Ser Asp Tyr Ala Lys Tyr Tyr Ala Leu 
    450                 455                 460                 


Val Cys Tyr Gly Pro Gly Ile Pro Ile Ser Thr Leu His Asp Gly Arg 
465                 470                 475                 480 


Thr Asp Gln Glu Ile Lys Ile Leu Glu Glu Asn Lys Glu Leu Glu Asn 
                485                 490                 495     


Ala Leu Lys Asn Ile Gln Leu Pro Lys Glu Glu Ile Lys Lys Leu Glu 
            500                 505                 510         


Val Asp Glu Ile Thr Leu Trp Tyr Lys Met Ile Leu Pro Pro Gln Phe 
        515                 520                 525             


Asp Arg Ser Lys Lys Tyr Pro Leu Leu Ile Gln Val Tyr Gly Gly Pro 
    530                 535                 540                 


Cys Ser Gln Ser Val Arg Ser Val Phe Ala Val Asn Trp Ile Ser Tyr 
545                 550                 555                 560 


Leu Ala Ser Lys Glu Gly Met Val Ile Ala Leu Val Asp Gly Arg Gly 
                565                 570                 575     


Thr Ala Phe Gln Gly Asp Lys Leu Leu Tyr Ala Val Tyr Arg Lys Leu 
            580                 585                 590         


Gly Val Tyr Glu Val Glu Asp Gln Ile Thr Ala Val Arg Lys Phe Ile 
        595                 600                 605             


Glu Met Gly Phe Ile Asp Glu Lys Arg Ile Ala Ile Trp Gly Trp Ser 
    610                 615                 620                 


Tyr Gly Gly Tyr Val Ser Ser Leu Ala Leu Ala Ser Gly Thr Gly Leu 
625                 630                 635                 640 


Phe Lys Cys Gly Ile Ala Val Ala Pro Val Ser Ser Trp Glu Tyr Tyr 
                645                 650                 655     


Ala Ser Val Tyr Thr Glu Arg Phe Met Gly Leu Pro Thr Lys Asp Asp 
            660                 665                 670         


Asn Leu Glu His Tyr Lys Asn Ser Thr Val Met Ala Arg Ala Glu Tyr 
        675                 680                 685             


Phe Arg Asn Val Asp Tyr Leu Leu Ile His Gly Thr Ala Asp Asp Asn 
    690                 695                 700                 


Val His Phe Gln Asn Ser Ala Gln Ile Ala Lys Ala Leu Val Asn Ala 
705                 710                 715                 720 


Gln Val Asp Phe Gln Ala Met Trp Tyr Ser Asp Gln Asn His Gly Leu 
                725                 730                 735     


Ser Gly Leu Ser Thr Asn His Leu Tyr Thr His Met Thr His Phe Leu 
            740                 745                 750         


Lys Gln Cys Phe Ser Leu Ser Asp 
        755                 760 


<210>  5101
<211>  735
<212>  PRT
<213>  Homo Sapiens

<400>  5101

Met Lys Thr Trp Val Lys Ile Val Phe Gly Val Ala Thr Ser Ala Val 
1               5                   10                  15      


Leu Ala Leu Leu Val Met Cys Ile Val Leu Arg Pro Ser Arg Val His 
            20                  25                  30          


Asn Ser Glu Glu Asn Thr Met Arg Ala Leu Thr Leu Lys Asp Ile Leu 
        35                  40                  45              


Asn Gly Thr Phe Ser Tyr Lys Thr Phe Phe Pro Asn Trp Ile Ser Gly 
    50                  55                  60                  


Gln Glu Tyr Leu His Gln Ser Ala Asp Asn Asn Ile Val Leu Tyr Asn 
65                  70                  75                  80  


Ile Glu Thr Gly Gln Ser Tyr Thr Ile Leu Ser Asn Arg Thr Met Leu 
                85                  90                  95      


Trp Arg Tyr Ser Tyr Thr Ala Thr Tyr Tyr Ile Tyr Asp Leu Ser Asn 
            100                 105                 110         


Gly Glu Phe Val Arg Gly Asn Glu Leu Pro Arg Pro Ile Gln Tyr Leu 
        115                 120                 125             


Cys Trp Ser Pro Val Gly Ser Lys Leu Ala Tyr Val Tyr Gln Asn Asn 
    130                 135                 140                 


Ile Tyr Leu Lys Gln Arg Pro Gly Asp Pro Pro Phe Gln Ile Thr Phe 
145                 150                 155                 160 


Asn Gly Arg Glu Asn Lys Ile Phe Asn Gly Ile Pro Asp Trp Val Tyr 
                165                 170                 175     


Glu Glu Glu Met Leu Ala Thr Lys Tyr Ala Leu Trp Trp Ser Pro Asn 
            180                 185                 190         


Gly Lys Phe Leu Ala Tyr Ala Glu Phe Asn Asp Thr Asp Ile Pro Val 
        195                 200                 205             


Ile Ala Tyr Ser Tyr Tyr Gly Asp Glu Gln Tyr Pro Arg Thr Ile Asn 
    210                 215                 220                 


Ile Pro Tyr Pro Lys Ala Gly Ala Lys Asn Pro Val Val Arg Ile Phe 
225                 230                 235                 240 


Ile Ile Asp Thr Thr Tyr Pro Ala Tyr Val Gly Pro Gln Glu Val Pro 
                245                 250                 255     


Val Pro Ala Met Ile Ala Ser Ser Asp Tyr Tyr Phe Ser Trp Leu Thr 
            260                 265                 270         


Trp Val Thr Asp Glu Arg Val Cys Leu Gln Trp Leu Lys Arg Val Gln 
        275                 280                 285             


Asn Val Ser Val Leu Ser Ile Cys Asp Phe Arg Glu Asp Trp Gln Thr 
    290                 295                 300                 


Trp Asp Cys Pro Lys Thr Gln Glu His Ile Glu Glu Ser Arg Thr Gly 
305                 310                 315                 320 


Trp Ala Gly Gly Phe Phe Val Ser Thr Pro Val Phe Ser Tyr Asp Ala 
                325                 330                 335     


Ile Ser Tyr Tyr Lys Ile Phe Ser Asp Lys Asp Gly Tyr Lys His Ile 
            340                 345                 350         


His Tyr Ile Lys Asp Thr Val Glu Asn Ala Ile Gln Ile Thr Ser Gly 
        355                 360                 365             


Lys Trp Glu Ala Ile Asn Ile Phe Arg Val Thr Gln Asp Ser Leu Phe 
    370                 375                 380                 


Tyr Ser Ser Asn Glu Phe Glu Glu Tyr Pro Gly Arg Arg Asn Ile Tyr 
385                 390                 395                 400 


Arg Ile Ser Ile Gly Ser Tyr Pro Pro Ser Lys Lys Cys Val Thr Cys 
                405                 410                 415     


His Leu Arg Lys Glu Arg Cys Gln Tyr Tyr Thr Ala Ser Phe Ser Asp 
            420                 425                 430         


Tyr Ala Lys Tyr Tyr Ala Leu Val Cys Tyr Gly Pro Gly Ile Pro Ile 
        435                 440                 445             


Ser Thr Leu His Asp Gly Arg Thr Asp Gln Glu Ile Lys Ile Leu Glu 
    450                 455                 460                 


Glu Asn Lys Glu Leu Glu Asn Ala Leu Lys Asn Ile Gln Leu Pro Lys 
465                 470                 475                 480 


Glu Glu Ile Lys Lys Leu Glu Val Asp Glu Ile Thr Leu Trp Tyr Lys 
                485                 490                 495     


Met Ile Leu Pro Pro Gln Phe Asp Arg Ser Lys Lys Tyr Pro Leu Leu 
            500                 505                 510         


Ile Gln Val Tyr Gly Gly Pro Cys Ser Gln Ser Val Arg Ser Val Phe 
        515                 520                 525             


Ala Val Asn Trp Ile Ser Tyr Leu Ala Ser Lys Glu Gly Met Val Ile 
    530                 535                 540                 


Ala Leu Val Asp Gly Arg Gly Thr Ala Phe Gln Gly Asp Lys Leu Leu 
545                 550                 555                 560 


Tyr Ala Val Tyr Arg Lys Leu Gly Val Tyr Glu Val Glu Asp Gln Ile 
                565                 570                 575     


Thr Ala Val Arg Lys Phe Ile Glu Met Gly Phe Ile Asp Glu Lys Arg 
            580                 585                 590         


Ile Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Ser Ser Leu Ala 
        595                 600                 605             


Leu Ala Ser Gly Thr Gly Leu Phe Lys Cys Gly Ile Ala Val Ala Pro 
    610                 615                 620                 


Val Ser Ser Trp Glu Tyr Tyr Ala Ser Val Tyr Thr Glu Arg Phe Met 
625                 630                 635                 640 


Gly Leu Pro Thr Lys Asp Asp Asn Leu Glu His Tyr Lys Asn Ser Thr 
                645                 650                 655     


Val Met Ala Arg Ala Glu Tyr Phe Arg Asn Val Asp Tyr Leu Leu Ile 
            660                 665                 670         


His Gly Thr Ala Asp Asp Asn Val His Phe Gln Asn Ser Ala Gln Ile 
        675                 680                 685             


Ala Lys Ala Leu Val Asn Ala Gln Val Asp Phe Gln Ala Met Trp Tyr 
    690                 695                 700                 


Ser Asp Gln Asn His Gly Leu Ser Gly Leu Ser Thr Asn His Leu Tyr 
705                 710                 715                 720 


Thr His Met Thr His Phe Leu Lys Gln Cys Phe Ser Leu Ser Asp 
                725                 730                 735 


<210>  5102
<211>  759
<212>  PRT
<213>  Homo Sapiens

<400>  5102

Met Thr Trp Val Lys Ile Val Phe Gly Val Ala Thr Ser Ala Val Leu 
1               5                   10                  15      


Ala Leu Leu Val Met Cys Ile Val Leu Arg Pro Ser Arg Val His Asn 
            20                  25                  30          


Ser Glu Glu Asn Thr Met Arg Ala Leu Thr Leu Lys Asp Ile Leu Asn 
        35                  40                  45              


Gly Thr Phe Ser Tyr Lys Thr Phe Phe Pro Asn Trp Ile Ser Gly Gln 
    50                  55                  60                  


Glu Tyr Leu His Gln Ser Ala Asp Asn Asn Ile Val Leu Tyr Asn Ile 
65                  70                  75                  80  


Glu Thr Gly Gln Ser Tyr Thr Ile Leu Ser Asn Arg Thr Met Lys Ser 
                85                  90                  95      


Val Asn Ala Ser Asn Tyr Gly Leu Ser Pro Asp Arg Gln Phe Val Tyr 
            100                 105                 110         


Leu Glu Ser Asp Tyr Ser Lys Leu Trp Arg Tyr Ser Tyr Thr Ala Thr 
        115                 120                 125             


Tyr Tyr Ile Tyr Asp Leu Ser Asn Gly Glu Phe Val Arg Gly Asn Glu 
    130                 135                 140                 


Leu Pro Arg Pro Ile Gln Tyr Leu Cys Trp Ser Pro Val Gly Ser Lys 
145                 150                 155                 160 


Leu Ala Tyr Val Tyr Gln Asn Asn Ile Tyr Leu Lys Gln Arg Pro Gly 
                165                 170                 175     


Asp Pro Pro Phe Gln Ile Thr Phe Asn Gly Arg Glu Asn Lys Ile Phe 
            180                 185                 190         


Asn Gly Ile Pro Asp Trp Val Tyr Glu Glu Glu Met Leu Ala Thr Lys 
        195                 200                 205             


Tyr Ala Leu Trp Trp Ser Pro Asn Gly Lys Phe Leu Ala Tyr Ala Glu 
    210                 215                 220                 


Phe Asn Asp Thr Asp Ile Pro Val Ile Ala Tyr Ser Tyr Tyr Gly Asp 
225                 230                 235                 240 


Glu Gln Tyr Pro Arg Thr Ile Asn Ile Pro Tyr Pro Lys Ala Gly Ala 
                245                 250                 255     


Lys Asn Pro Val Val Arg Ile Phe Ile Ile Asp Thr Thr Tyr Pro Ala 
            260                 265                 270         


Tyr Val Gly Pro Gln Glu Val Pro Val Pro Ala Met Ile Ala Ser Ser 
        275                 280                 285             


Asp Tyr Tyr Phe Ser Trp Leu Thr Trp Val Thr Asp Glu Arg Val Cys 
    290                 295                 300                 


Leu Gln Trp Leu Lys Arg Val Gln Asn Val Ser Val Leu Ser Ile Cys 
305                 310                 315                 320 


Asp Phe Arg Glu Asp Trp Gln Thr Trp Asp Cys Pro Lys Thr Gln Glu 
                325                 330                 335     


His Ile Glu Glu Ser Arg Thr Gly Trp Ala Gly Gly Phe Phe Val Ser 
            340                 345                 350         


Thr Pro Val Phe Ser Tyr Asp Ala Ile Ser Tyr Tyr Lys Ile Phe Ser 
        355                 360                 365             


Asp Lys Asp Gly Tyr Lys His Ile His Tyr Ile Lys Asp Thr Val Glu 
    370                 375                 380                 


Asn Ala Ile Gln Ile Thr Ser Gly Lys Trp Glu Ala Ile Asn Ile Phe 
385                 390                 395                 400 


Arg Val Thr Gln Asp Ser Leu Phe Tyr Ser Ser Asn Glu Phe Glu Glu 
                405                 410                 415     


Tyr Pro Gly Arg Arg Asn Ile Tyr Arg Ile Ser Ile Gly Ser Tyr Pro 
            420                 425                 430         


Pro Ser Lys Lys Cys Val Thr Cys His Leu Arg Lys Glu Arg Cys Gln 
        435                 440                 445             


Tyr Tyr Thr Ala Ser Phe Ser Asp Tyr Ala Lys Tyr Tyr Ala Leu Val 
    450                 455                 460                 


Cys Tyr Gly Pro Gly Ile Pro Ile Ser Thr Leu His Asp Gly Arg Thr 
465                 470                 475                 480 


Asp Gln Glu Ile Lys Ile Leu Glu Glu Asn Lys Glu Leu Glu Asn Ala 
                485                 490                 495     


Leu Lys Asn Ile Gln Leu Pro Lys Glu Glu Ile Lys Lys Leu Glu Val 
            500                 505                 510         


Asp Glu Ile Thr Leu Trp Tyr Lys Met Ile Leu Pro Pro Gln Phe Asp 
        515                 520                 525             


Arg Ser Lys Lys Tyr Pro Leu Leu Ile Gln Val Tyr Gly Gly Pro Cys 
    530                 535                 540                 


Ser Gln Ser Val Arg Ser Val Phe Ala Val Asn Trp Ile Ser Tyr Leu 
545                 550                 555                 560 


Ala Ser Lys Glu Gly Met Val Ile Ala Leu Val Asp Gly Arg Gly Thr 
                565                 570                 575     


Ala Phe Gln Gly Asp Lys Leu Leu Tyr Ala Val Tyr Arg Lys Leu Gly 
            580                 585                 590         


Val Tyr Glu Val Glu Asp Gln Ile Thr Ala Val Arg Lys Phe Ile Glu 
        595                 600                 605             


Met Gly Phe Ile Asp Glu Lys Arg Ile Ala Ile Trp Gly Trp Ser Tyr 
    610                 615                 620                 


Gly Gly Tyr Val Ser Ser Leu Ala Leu Ala Ser Gly Thr Gly Leu Phe 
625                 630                 635                 640 


Lys Cys Gly Ile Ala Val Ala Pro Val Ser Ser Trp Glu Tyr Tyr Ala 
                645                 650                 655     


Ser Val Tyr Thr Glu Arg Phe Met Gly Leu Pro Thr Lys Asp Asp Asn 
            660                 665                 670         


Leu Glu His Tyr Lys Asn Ser Thr Val Met Ala Arg Ala Glu Tyr Phe 
        675                 680                 685             


Arg Asn Val Asp Tyr Leu Leu Ile His Gly Thr Ala Asp Asp Asn Val 
    690                 695                 700                 


His Phe Gln Asn Ser Ala Gln Ile Ala Lys Ala Leu Val Asn Ala Gln 
705                 710                 715                 720 


Val Asp Phe Gln Ala Met Trp Tyr Ser Asp Gln Asn His Gly Leu Ser 
                725                 730                 735     


Gly Leu Ser Thr Asn His Leu Tyr Thr His Met Thr His Phe Leu Lys 
            740                 745                 750         


Gln Cys Phe Ser Leu Ser Asp 
        755                 


<210>  5103
<211>  47
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5103

Xaa Tyr Thr Glu Arg Phe Met Gly Leu Pro Thr Lys Asp Asp Asn Leu 
1               5                   10                  15      


Glu His Tyr Lys Asn Ser Thr Val Met Ala Arg Ala Glu Tyr Phe Arg 
            20                  25                  30          


Asn Val Asp Tyr Leu Leu Ile His Gly Thr Ala Asp Gly Glu Val 
        35                  40                  45          


<210>  5104
<211>  86
<212>  PRT
<213>  Homo Sapiens

<400>  5104

Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      


Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 
            20                  25                  30          


Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 
        35                  40                  45              


Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 
    50                  55                  60                  


Pro Asp Val Asn Met Glu Ser Ser Arg Asn Ala His Ser Pro Ala Thr 
65                  70                  75                  80  


Pro Ser Ala Lys Arg Lys 
                85      


<210>  5105
<211>  103
<212>  PRT
<213>  Homo Sapiens

<400>  5105

Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      


Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 
            20                  25                  30          


Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 
        35                  40                  45              


Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 
    50                  55                  60                  


Pro Asp Val Asn Met Glu Ser Ser Arg Asn Ala His Ser Pro Ala Thr 
65                  70                  75                  80  


Pro Ser Ala Lys Arg Lys Asp Pro Asp Leu Thr Trp Gly Gly Phe Val 
                85                  90                  95      


Phe Phe Phe Cys Gln Phe His 
            100             


<210>  5106
<211>  132
<212>  PRT
<213>  Homo Sapiens

<400>  5106

Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      


Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 
            20                  25                  30          


Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 
        35                  40                  45              


Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 
    50                  55                  60                  


Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 
65                  70                  75                  80  


Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 
                85                  90                  95      


Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Asp 
            100                 105                 110         


Val Asn Met Glu Ser Ser Arg Asn Ala His Ser Pro Ala Thr Pro Ser 
        115                 120                 125             


Ala Lys Arg Lys 
    130         


<210>  5107
<211>  149
<212>  PRT
<213>  Homo Sapiens

<400>  5107

Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      


Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 
            20                  25                  30          


Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 
        35                  40                  45              


Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 
    50                  55                  60                  


Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 
65                  70                  75                  80  


Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 
                85                  90                  95      


Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Asp 
            100                 105                 110         


Val Asn Met Glu Ser Ser Arg Asn Ala His Ser Pro Ala Thr Pro Ser 
        115                 120                 125             


Ala Lys Arg Lys Asp Pro Asp Leu Thr Trp Gly Gly Phe Val Phe Phe 
    130                 135                 140                 


Phe Cys Gln Phe His 
145                 


<210>  5108
<211>  149
<212>  PRT
<213>  Homo Sapiens

<400>  5108

Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      


Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 
            20                  25                  30          


Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 
        35                  40                  45              


Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 
    50                  55                  60                  


Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 
65                  70                  75                  80  


Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 
                85                  90                  95      


Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Asp 
            100                 105                 110         


Val Asn Met Glu Ser Ser Arg Asn Ala His Ser Pro Ala Thr Pro Ser 
        115                 120                 125             


Ala Lys Arg Lys Asp Pro Asp Leu Thr Trp Gly Gly Phe Val Phe Phe 
    130                 135                 140                 


Phe Cys Gln Phe His 
145                 


<210>  5109
<211>  335
<212>  PRT
<213>  Homo Sapiens

<400>  5109

Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      


Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 
            20                  25                  30          


Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 
        35                  40                  45              


Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 
    50                  55                  60                  


Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 
65                  70                  75                  80  


Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 
                85                  90                  95      


Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Gly 
            100                 105                 110         


Leu Glu Val Glu Ile Asn Cys Thr Arg Thr Gln Asn Thr Lys Cys Arg 
        115                 120                 125             


Cys Lys Pro Asn Phe Phe Cys Asn Ser Thr Val Cys Glu His Cys Asp 
    130                 135                 140                 


Pro Cys Thr Lys Cys Glu His Gly Ile Ile Lys Glu Cys Thr Leu Thr 
145                 150                 155                 160 


Ser Asn Thr Lys Cys Lys Glu Glu Gly Ser Arg Ser Asn Leu Gly Trp 
                165                 170                 175     


Leu Cys Leu Leu Leu Leu Pro Ile Pro Leu Ile Val Trp Val Lys Arg 
            180                 185                 190         


Lys Glu Val Gln Lys Thr Cys Arg Lys His Arg Lys Glu Asn Gln Gly 
        195                 200                 205             


Ser His Glu Ser Pro Thr Leu Asn Pro Glu Thr Val Ala Ile Asn Leu 
    210                 215                 220                 


Ser Asp Val Asp Leu Ser Lys Tyr Ile Thr Thr Ile Ala Gly Val Met 
225                 230                 235                 240 


Thr Leu Ser Gln Val Lys Gly Phe Val Arg Lys Asn Gly Val Asn Glu 
                245                 250                 255     


Ala Lys Ile Asp Glu Ile Lys Asn Asp Asn Val Gln Asp Thr Ala Glu 
            260                 265                 270         


Gln Lys Val Gln Leu Leu Arg Asn Trp His Gln Leu His Gly Lys Lys 
        275                 280                 285             


Glu Ala Tyr Asp Thr Leu Ile Lys Asp Leu Lys Lys Ala Asn Leu Cys 
    290                 295                 300                 


Thr Leu Ala Glu Lys Ile Gln Thr Ile Ile Leu Lys Asp Ile Thr Ser 
305                 310                 315                 320 


Asp Ser Glu Asn Ser Asn Phe Arg Asn Glu Ile Gln Ser Leu Val 
                325                 330                 335 


<210>  5110
<211>  233
<212>  PRT
<213>  Homo Sapiens

<400>  5110

Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      


Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 
            20                  25                  30          


Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 
        35                  40                  45              


Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 
    50                  55                  60                  


Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 
65                  70                  75                  80  


Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 
                85                  90                  95      


Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Gly 
            100                 105                 110         


Leu Glu Val Glu Ile Asn Cys Thr Arg Thr Gln Asn Thr Lys Cys Arg 
        115                 120                 125             


Cys Lys Pro Asn Phe Phe Cys Asn Ser Thr Val Cys Glu His Cys Asp 
    130                 135                 140                 


Pro Cys Thr Lys Cys Glu His Gly Ile Ile Lys Glu Cys Thr Leu Thr 
145                 150                 155                 160 


Ser Asn Thr Lys Cys Lys Glu Glu Gly Ser Arg Ser Asn Leu Gly Trp 
                165                 170                 175     


Leu Cys Leu Leu Leu Leu Pro Ile Pro Leu Ile Val Trp Val Lys Arg 
            180                 185                 190         


Lys Glu Val Gln Lys Thr Cys Arg Lys His Arg Lys Glu Asn Gln Gly 
        195                 200                 205             


Ser His Glu Ser Pro Thr Leu Asn Pro Glu Thr Val Ala Ile Asn Leu 
    210                 215                 220                 


Ser Asp Tyr Phe Leu Phe Phe Arg Cys 
225                 230             


<210>  5111
<211>  244
<212>  PRT
<213>  Homo Sapiens

<400>  5111

Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      


Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 
            20                  25                  30          


Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 
        35                  40                  45              


Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 
    50                  55                  60                  


Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 
65                  70                  75                  80  


Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 
                85                  90                  95      


Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Gly 
            100                 105                 110         


Leu Glu Val Glu Ile Asn Cys Thr Arg Thr Gln Asn Thr Lys Cys Arg 
        115                 120                 125             


Cys Lys Pro Asn Phe Phe Cys Asn Ser Thr Val Cys Glu His Cys Asp 
    130                 135                 140                 


Pro Cys Thr Lys Cys Glu His Gly Ile Ile Lys Glu Cys Thr Leu Thr 
145                 150                 155                 160 


Ser Asn Thr Lys Cys Lys Glu Glu Gly Ser Arg Ser Asn Leu Gly Trp 
                165                 170                 175     


Leu Cys Leu Leu Leu Leu Pro Ile Pro Leu Ile Val Trp Val Lys Arg 
            180                 185                 190         


Lys Glu Val Gln Lys Thr Cys Arg Lys His Arg Lys Glu Asn Gln Gly 
        195                 200                 205             


Ser His Glu Ser Pro Thr Leu Asn Pro Met Glu Ser Cys Ser Ile Ala 
    210                 215                 220                 


Gln Ala Gly Val Gln Gly Cys Asn His Gly Ser Leu Gln Pro Gln Ser 
225                 230                 235                 240 


Pro Gly Leu Lys 
                


<210>  5112
<211>  220
<212>  PRT
<213>  Homo Sapiens

<400>  5112

Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      


Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 
            20                  25                  30          


Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 
        35                  40                  45              


Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 
    50                  55                  60                  


Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 
65                  70                  75                  80  


Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 
                85                  90                  95      


Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Gly 
            100                 105                 110         


Leu Glu Val Glu Ile Asn Cys Thr Arg Thr Gln Asn Thr Lys Cys Arg 
        115                 120                 125             


Cys Lys Pro Asn Phe Phe Cys Asn Ser Thr Val Cys Glu His Cys Asp 
    130                 135                 140                 


Pro Cys Thr Lys Cys Glu His Gly Ile Ile Lys Glu Cys Thr Leu Thr 
145                 150                 155                 160 


Ser Asn Thr Lys Cys Lys Glu Glu Gly Ser Arg Ser Asn Leu Gly Trp 
                165                 170                 175     


Leu Cys Leu Leu Leu Leu Pro Ile Pro Leu Ile Val Trp Val Lys Arg 
            180                 185                 190         


Lys Glu Val Gln Lys Thr Cys Arg Lys His Arg Lys Glu Asn Gln Gly 
        195                 200                 205             


Ser His Glu Ser Pro Thr Leu Asn Pro Met Leu Thr 
    210                 215                 220 


<210>  5113
<211>  314
<212>  PRT
<213>  Homo Sapiens

<400>  5113

Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      


Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 
            20                  25                  30          


Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 
        35                  40                  45              


Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 
    50                  55                  60                  


Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 
65                  70                  75                  80  


Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 
                85                  90                  95      


Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Gly 
            100                 105                 110         


Leu Glu Val Glu Ile Asn Cys Thr Arg Thr Gln Asn Thr Lys Cys Arg 
        115                 120                 125             


Cys Lys Pro Asn Phe Phe Cys Asn Ser Thr Val Cys Glu His Cys Asp 
    130                 135                 140                 


Pro Cys Thr Lys Cys Glu His Gly Ile Ile Lys Glu Cys Thr Leu Thr 
145                 150                 155                 160 


Ser Asn Thr Lys Cys Lys Glu Glu Val Lys Arg Lys Glu Val Gln Lys 
                165                 170                 175     


Thr Cys Arg Lys His Arg Lys Glu Asn Gln Gly Ser His Glu Ser Pro 
            180                 185                 190         


Thr Leu Asn Pro Glu Thr Val Ala Ile Asn Leu Ser Asp Val Asp Leu 
        195                 200                 205             


Ser Lys Tyr Ile Thr Thr Ile Ala Gly Val Met Thr Leu Ser Gln Val 
    210                 215                 220                 


Lys Gly Phe Val Arg Lys Asn Gly Val Asn Glu Ala Lys Ile Asp Glu 
225                 230                 235                 240 


Ile Lys Asn Asp Asn Val Gln Asp Thr Ala Glu Gln Lys Val Gln Leu 
                245                 250                 255     


Leu Arg Asn Trp His Gln Leu His Gly Lys Lys Glu Ala Tyr Asp Thr 
            260                 265                 270         


Leu Ile Lys Asp Leu Lys Lys Ala Asn Leu Cys Thr Leu Ala Glu Lys 
        275                 280                 285             


Ile Gln Thr Ile Ile Leu Lys Asp Ile Thr Ser Asp Ser Glu Asn Ser 
    290                 295                 300                 


Asn Phe Arg Asn Glu Ile Gln Ser Leu Val 
305                 310                 


<210>  5114
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  5114

Leu Ser Lys Lys Pro Leu Glu Glu Lys Pro Ser Gln Pro Tyr Ser Ala 
1               5                   10                  15      


Arg Glu Ser Leu Ser Glu Val Gln Ser Leu Ser Ser Phe Gln Ser Glu 
            20                  25                  30          


Ser Cys Asp Asp Asn Ala Ser Ile Val Thr Val Met His Leu Val Asn 
        35                  40                  45              


Ala Val Val Asp Thr Val Ser Thr Glu Glu Ser Leu Ala Ala Pro Asp 
    50                  55                  60                  


Leu Ser Lys Pro Arg Gly Tyr His Trp Asp Thr Ser Asp Trp Met Pro 
65                  70                  75                  80  


Ser Val Pro Leu Pro Asp Ile Gln Glu Phe Pro Asn Tyr Glu Val Ile 
                85                  90                  95      


Asp Glu Gln Thr Pro Leu Tyr Ser Ala Asp Pro Asn Ala Ile Asp Thr 
            100                 105                 110         


Asp Tyr Tyr Pro Gly Gly Tyr 
        115                 


<210>  5115
<211>  4588
<212>  PRT
<213>  Homo Sapiens

<400>  5115

Met Gly Arg His Leu Ala Leu Leu Leu Leu Leu Leu Leu Leu Phe Gln 
1               5                   10                  15      


His Phe Gly Asp Ser Asp Gly Ser Gln Arg Leu Glu Gln Thr Pro Leu 
            20                  25                  30          


Gln Phe Thr His Leu Glu Tyr Asn Val Thr Val Gln Glu Asn Ser Ala 
        35                  40                  45              


Ala Lys Thr Tyr Val Gly His Pro Val Lys Met Gly Val Tyr Ile Thr 
    50                  55                  60                  


His Pro Ala Trp Glu Val Arg Tyr Lys Ile Val Ser Gly Asp Ser Glu 
65                  70                  75                  80  


Asn Leu Phe Lys Ala Glu Glu Tyr Ile Leu Gly Asp Phe Cys Phe Leu 
                85                  90                  95      


Arg Ile Arg Thr Lys Gly Gly Asn Thr Ala Ile Leu Asn Arg Glu Val 
            100                 105                 110         


Lys Asp His Tyr Thr Leu Ile Val Lys Ala Leu Glu Lys Asn Thr Asn 
        115                 120                 125             


Val Glu Ala Arg Thr Lys Val Arg Val Gln Val Leu Asp Thr Asn Asp 
    130                 135                 140                 


Leu Arg Pro Leu Phe Ser Pro Thr Ser Tyr Ser Val Ser Leu Pro Glu 
145                 150                 155                 160 


Asn Thr Ala Ile Arg Thr Ser Ile Ala Arg Val Ser Ala Thr Asp Ala 
                165                 170                 175     


Asp Ile Gly Thr Asn Gly Glu Phe Tyr Tyr Ser Phe Lys Asp Arg Thr 
            180                 185                 190         


Asp Met Phe Ala Ile His Pro Thr Ser Gly Val Ile Val Leu Thr Gly 
        195                 200                 205             


Arg Leu Asp Tyr Leu Glu Thr Lys Leu Tyr Glu Met Glu Ile Leu Ala 
    210                 215                 220                 


Ala Asp Arg Gly Met Lys Leu Tyr Gly Ser Ser Gly Ile Ser Ser Met 
225                 230                 235                 240 


Ala Lys Leu Thr Val His Ile Glu Gln Ala Asn Glu Cys Ala Pro Val 
                245                 250                 255     


Ile Thr Ala Val Thr Leu Ser Pro Ser Glu Leu Asp Arg Asp Pro Ala 
            260                 265                 270         


Tyr Ala Ile Val Thr Val Asp Asp Cys Asp Gln Gly Ala Asn Gly Asp 
        275                 280                 285             


Ile Ala Ser Leu Ser Ile Val Ala Gly Asp Leu Leu Gln Gln Phe Arg 
    290                 295                 300                 


Thr Val Arg Ser Phe Pro Gly Ser Lys Glu Tyr Lys Val Lys Ala Ile 
305                 310                 315                 320 


Gly Gly Ile Asp Trp Asp Ser His Pro Phe Gly Tyr Asn Leu Thr Leu 
                325                 330                 335     


Gln Ala Lys Asp Lys Gly Thr Pro Pro Gln Phe Ser Ser Val Lys Val 
            340                 345                 350         


Ile His Val Thr Ser Pro Gln Phe Lys Ala Gly Pro Val Lys Phe Glu 
        355                 360                 365             


Lys Asp Val Tyr Arg Ala Glu Ile Ser Glu Phe Ala Pro Pro Asn Thr 
    370                 375                 380                 


Pro Val Val Met Val Lys Ala Ile Pro Ala Tyr Ser His Leu Arg Tyr 
385                 390                 395                 400 


Val Phe Lys Ser Thr Pro Gly Lys Ala Lys Phe Ser Leu Asn Tyr Asn 
                405                 410                 415     


Thr Gly Leu Ile Ser Ile Leu Glu Pro Val Lys Arg Gln Gln Ala Ala 
            420                 425                 430         


His Phe Glu Leu Glu Val Thr Thr Ser Asp Arg Lys Ala Ser Thr Lys 
        435                 440                 445             


Val Leu Val Lys Val Leu Gly Ala Asn Ser Asn Pro Pro Glu Phe Thr 
    450                 455                 460                 


Gln Thr Ala Tyr Lys Ala Ala Phe Asp Glu Asn Val Pro Ile Gly Thr 
465                 470                 475                 480 


Thr Val Met Ser Leu Ser Ala Val Asp Pro Asp Glu Gly Glu Asn Gly 
                485                 490                 495     


Tyr Val Thr Tyr Ser Ile Ala Asn Leu Asn His Val Pro Phe Ala Ile 
            500                 505                 510         


Asp His Phe Thr Gly Ala Val Ser Thr Ser Glu Asn Leu Asp Tyr Glu 
        515                 520                 525             


Leu Met Pro Arg Val Tyr Thr Leu Arg Ile Arg Ala Ser Asp Trp Gly 
    530                 535                 540                 


Leu Pro Tyr Arg Arg Glu Val Glu Val Leu Ala Thr Ile Thr Leu Asn 
545                 550                 555                 560 


Asn Leu Asn Asp Asn Thr Pro Leu Phe Glu Lys Ile Asn Cys Glu Gly 
                565                 570                 575     


Thr Ile Pro Arg Asp Leu Gly Val Gly Glu Gln Ile Thr Thr Val Ser 
            580                 585                 590         


Ala Ile Asp Ala Asp Glu Leu Gln Leu Val Gln Tyr Gln Ile Glu Ala 
        595                 600                 605             


Gly Asn Glu Leu Asp Phe Phe Ser Leu Asn Pro Asn Ser Gly Val Leu 
    610                 615                 620                 


Ser Leu Lys Arg Ser Leu Met Asp Gly Leu Gly Ala Lys Val Ser Phe 
625                 630                 635                 640 


His Ser Leu Arg Ile Thr Ala Thr Asp Gly Glu Asn Phe Ala Thr Pro 
                645                 650                 655     


Leu Tyr Ile Asn Ile Thr Val Ala Ala Ser His Lys Leu Val Asn Leu 
            660                 665                 670         


Gln Cys Glu Glu Thr Gly Val Ala Lys Met Leu Ala Glu Lys Leu Leu 
        675                 680                 685             


Gln Ala Asn Lys Leu His Asn Gln Gly Glu Val Glu Asp Ile Phe Phe 
    690                 695                 700                 


Asp Ser His Ser Val Asn Ala His Ile Pro Gln Phe Arg Ser Thr Leu 
705                 710                 715                 720 


Pro Thr Gly Ile Gln Val Lys Glu Asn Gln Pro Val Gly Ser Ser Val 
                725                 730                 735     


Ile Phe Met Asn Ser Thr Asp Leu Asp Thr Gly Phe Asn Gly Lys Leu 
            740                 745                 750         


Val Tyr Ala Val Ser Gly Gly Asn Glu Asp Ser Cys Phe Met Ile Asp 
        755                 760                 765             


Met Glu Thr Gly Met Leu Lys Ile Leu Ser Pro Leu Asp Arg Glu Thr 
    770                 775                 780                 


Thr Asp Lys Tyr Thr Leu Asn Ile Thr Val Tyr Asp Leu Gly Ile Pro 
785                 790                 795                 800 


Gln Lys Ala Ala Trp Arg Leu Leu His Val Val Val Val Asp Ala Asn 
                805                 810                 815     


Asp Asn Pro Pro Glu Phe Leu Gln Glu Ser Tyr Phe Val Glu Val Ser 
            820                 825                 830         


Glu Asp Lys Glu Val His Ser Glu Ile Ile Gln Val Glu Ala Thr Asp 
        835                 840                 845             


Lys Asp Leu Gly Pro Asn Gly His Val Thr Tyr Ser Ile Val Thr Asp 
    850                 855                 860                 


Thr Asp Thr Phe Ser Ile Asp Ser Val Thr Gly Val Val Asn Ile Ala 
865                 870                 875                 880 


Arg Pro Leu Asp Arg Glu Leu Gln His Glu His Ser Leu Lys Ile Glu 
                885                 890                 895     


Ala Arg Asp Gln Ala Arg Glu Glu Pro Gln Leu Phe Ser Thr Val Val 
            900                 905                 910         


Val Lys Val Ser Leu Glu Asp Val Asn Asp Asn Pro Pro Thr Phe Ile 
        915                 920                 925             


Pro Pro Asn Tyr Arg Val Lys Val Arg Glu Asp Leu Pro Glu Gly Thr 
    930                 935                 940                 


Val Ile Met Trp Leu Glu Ala His Asp Pro Asp Leu Gly Gln Ser Gly 
945                 950                 955                 960 


Gln Val Arg Tyr Ser Leu Leu Asp His Gly Glu Gly Asn Phe Asp Val 
                965                 970                 975     


Asp Lys Leu Ser Gly Ala Val Arg Ile Val Gln Gln Leu Asp Phe Glu 
            980                 985                 990         


Lys Lys Gln Val Tyr Asn Leu Thr  Val Arg Ala Lys Asp  Lys Gly Lys 
        995                 1000                 1005             


Pro Val  Ser Leu Ser Ser Thr  Cys Tyr Val Glu Val  Glu Val Val 
    1010                 1015                 1020             


Asp Val  Asn Glu Asn Leu His  Pro Pro Val Phe Ser  Ser Phe Val 
    1025                 1030                 1035             


Glu Lys  Gly Thr Val Lys Glu  Asp Ala Pro Val Gly  Ser Leu Val 
    1040                 1045                 1050             


Met Thr  Val Ser Ala His Asp  Glu Asp Ala Arg Arg  Asp Gly Glu 
    1055                 1060                 1065             


Ile Arg  Tyr Ser Ile Arg Asp  Gly Ser Gly Val Gly  Val Phe Lys 
    1070                 1075                 1080             


Ile Gly  Glu Glu Thr Gly Val  Ile Glu Thr Ser Asp  Arg Leu Asp 
    1085                 1090                 1095             


Arg Glu  Ser Thr Ser His Tyr  Trp Leu Thr Val Phe  Ala Thr Asp 
    1100                 1105                 1110             


Gln Gly  Val Val Pro Leu Ser  Ser Phe Ile Glu Ile  Tyr Ile Glu 
    1115                 1120                 1125             


Val Glu  Asp Val Asn Asp Asn  Ala Pro Gln Thr Ser  Glu Pro Val 
    1130                 1135                 1140             


Tyr Tyr  Pro Glu Ile Met Glu  Asn Ser Pro Lys Asp  Val Ser Val 
    1145                 1150                 1155             


Val Gln  Ile Glu Ala Phe Asp  Pro Asp Ser Ser Ser  Asn Asp Lys 
    1160                 1165                 1170             


Leu Met  Tyr Lys Ile Thr Ser  Gly Asn Pro Gln Gly  Phe Phe Ser 
    1175                 1180                 1185             


Ile His  Pro Lys Thr Gly Leu  Ile Thr Thr Thr Ser  Arg Lys Leu 
    1190                 1195                 1200             


Asp Arg  Glu Gln Gln Asp Glu  His Ile Leu Glu Val  Thr Val Thr 
    1205                 1210                 1215             


Asp Asn  Gly Ser Pro Pro Lys  Ser Thr Ile Ala Arg  Val Ile Val 
    1220                 1225                 1230             


Lys Ile  Leu Asp Glu Asn Asp  Asn Lys Pro Gln Phe  Leu Gln Lys 
    1235                 1240                 1245             


Phe Tyr  Lys Ile Arg Leu Pro  Glu Arg Glu Lys Pro  Asp Arg Glu 
    1250                 1255                 1260             


Arg Asn  Ala Arg Arg Glu Pro  Leu Tyr His Val Ile  Ala Thr Asp 
    1265                 1270                 1275             


Lys Asp  Glu Gly Pro Asn Ala  Glu Ile Ser Tyr Ser  Ile Glu Asp 
    1280                 1285                 1290             


Gly Asn  Glu His Gly Lys Phe  Phe Ile Glu Pro Lys  Thr Gly Val 
    1295                 1300                 1305             


Val Ser  Ser Lys Arg Phe Ser  Ala Ala Gly Glu Tyr  Asp Ile Leu 
    1310                 1315                 1320             


Ser Ile  Lys Ala Val Asp Asn  Gly Arg Pro Gln Lys  Ser Ser Thr 
    1325                 1330                 1335             


Thr Arg  Leu His Ile Glu Trp  Ile Ser Lys Pro Lys  Pro Ser Leu 
    1340                 1345                 1350             


Glu Pro  Ile Ser Phe Glu Glu  Ser Phe Phe Thr Phe  Thr Val Met 
    1355                 1360                 1365             


Glu Ser  Asp Pro Val Ala His  Met Ile Gly Val Ile  Ser Val Glu 
    1370                 1375                 1380             


Pro Pro  Gly Ile Pro Leu Trp  Phe Asp Ile Thr Gly  Gly Asn Tyr 
    1385                 1390                 1395             


Asp Ser  His Phe Asp Val Asp  Lys Gly Thr Gly Thr  Ile Ile Val 
    1400                 1405                 1410             


Ala Lys  Pro Leu Asp Ala Glu  Gln Lys Ser Asn Tyr  Asn Leu Thr 
    1415                 1420                 1425             


Val Glu  Ala Thr Asp Gly Thr  Thr Thr Ile Leu Thr  Gln Val Phe 
    1430                 1435                 1440             


Ile Lys  Val Ile Asp Thr Asn  Asp His Arg Pro Gln  Phe Ser Thr 
    1445                 1450                 1455             


Ser Lys  Tyr Glu Val Val Ile  Pro Glu Asp Thr Ala  Pro Glu Thr 
    1460                 1465                 1470             


Glu Ile  Leu Gln Ile Ser Ala  Val Asp Gln Asp Glu  Lys Asn Lys 
    1475                 1480                 1485             


Leu Ile  Tyr Thr Leu Gln Ser  Ser Arg Asp Pro Leu  Ser Leu Lys 
    1490                 1495                 1500             


Lys Phe  Arg Leu Asp Pro Ala  Thr Gly Ser Leu Tyr  Thr Ser Glu 
    1505                 1510                 1515             


Lys Leu  Asp His Glu Ala Val  His Gln His Thr Leu  Thr Val Met 
    1520                 1525                 1530             


Val Arg  Asp Gln Asp Val Pro  Val Lys Arg Asn Phe  Ala Arg Ile 
    1535                 1540                 1545             


Val Val  Asn Val Ser Asp Thr  Asn Asp His Ala Pro  Trp Phe Thr 
    1550                 1555                 1560             


Ala Ser  Ser Tyr Lys Gly Arg  Val Tyr Glu Ser Ala  Ala Val Gly 
    1565                 1570                 1575             


Ser Val  Val Leu Gln Val Thr  Ala Leu Asp Lys Asp  Lys Gly Lys 
    1580                 1585                 1590             


Asn Ala  Glu Val Leu Tyr Ser  Ile Glu Ser Gly Asn  Ile Gly Asn 
    1595                 1600                 1605             


Ser Phe  Met Ile Asp Pro Val  Leu Gly Ser Ile Lys  Thr Ala Lys 
    1610                 1615                 1620             


Glu Leu  Asp Arg Ser Asn Gln  Ala Glu Tyr Asp Leu  Met Val Lys 
    1625                 1630                 1635             


Ala Thr  Asp Lys Gly Ser Pro  Pro Met Ser Glu Ile  Thr Ser Val 
    1640                 1645                 1650             


Arg Ile  Phe Val Thr Ile Ala  Asp Asn Ala Ser Pro  Lys Phe Thr 
    1655                 1660                 1665             


Ser Lys  Glu Tyr Ser Val Glu  Leu Ser Glu Thr Val  Ser Ile Gly 
    1670                 1675                 1680             


Ser Phe  Val Gly Met Val Thr  Ala His Ser Gln Ser  Ser Val Val 
    1685                 1690                 1695             


Tyr Glu  Ile Lys Asp Gly Asn  Thr Gly Asp Ala Phe  Asp Ile Asn 
    1700                 1705                 1710             


Pro His  Ser Gly Thr Ile Ile  Thr Gln Lys Ala Leu  Asp Phe Glu 
    1715                 1720                 1725             


Thr Leu  Pro Ile Tyr Thr Leu  Ile Ile Gln Gly Thr  Asn Met Ala 
    1730                 1735                 1740             


Gly Leu  Ser Thr Asn Thr Thr  Val Leu Val His Leu  Gln Asp Glu 
    1745                 1750                 1755             


Asn Asp  Asn Ala Pro Val Phe  Met Gln Ala Glu Tyr  Thr Gly Leu 
    1760                 1765                 1770             


Ile Ser  Glu Ser Ala Ser Ile  Asn Ser Val Val Leu  Thr Asp Arg 
    1775                 1780                 1785             


Asn Val  Pro Leu Val Ile Arg  Ala Ala Asp Ala Asp  Lys Asp Ser 
    1790                 1795                 1800             


Asn Ala  Leu Leu Val Tyr His  Ile Val Glu Pro Ser  Val His Thr 
    1805                 1810                 1815             


Tyr Phe  Ala Ile Asp Ser Ser  Thr Gly Ala Ile His  Thr Val Leu 
    1820                 1825                 1830             


Ser Leu  Asp Tyr Glu Glu Thr  Ser Ile Phe His Phe  Thr Val Gln 
    1835                 1840                 1845             


Val His  Asp Met Gly Thr Pro  Arg Leu Phe Ala Glu  Tyr Ala Ala 
    1850                 1855                 1860             


Asn Val  Thr Val His Val Ile  Asp Ile Asn Asp Cys  Pro Pro Val 
    1865                 1870                 1875             


Phe Ala  Lys Pro Leu Tyr Glu  Ala Ser Leu Leu Leu  Pro Thr Tyr 
    1880                 1885                 1890             


Lys Gly  Val Lys Val Ile Thr  Val Asn Ala Thr Asp  Ala Asp Ser 
    1895                 1900                 1905             


Ser Ala  Phe Ser Gln Leu Ile  Tyr Ser Ile Thr Glu  Gly Asn Ile 
    1910                 1915                 1920             


Gly Glu  Lys Phe Ser Met Asp  Tyr Lys Thr Gly Ala  Leu Thr Val 
    1925                 1930                 1935             


Gln Asn  Thr Thr Gln Leu Arg  Ser Arg Tyr Glu Leu  Thr Val Arg 
    1940                 1945                 1950             


Ala Ser  Asp Gly Arg Phe Ala  Gly Leu Thr Ser Val  Lys Ile Asn 
    1955                 1960                 1965             


Val Lys  Glu Ser Lys Glu Ser  His Leu Lys Phe Thr  Gln Asp Val 
    1970                 1975                 1980             


Tyr Ser  Ala Val Val Lys Glu  Asn Ser Thr Glu Ala  Glu Thr Leu 
    1985                 1990                 1995             


Ala Val  Ile Thr Ala Ile Gly  Asn Pro Ile Asn Glu  Pro Leu Phe 
    2000                 2005                 2010             


Tyr His  Ile Leu Asn Pro Asp  Arg Arg Phe Lys Ile  Ser Arg Thr 
    2015                 2020                 2025             


Ser Gly  Val Leu Ser Thr Thr  Gly Thr Pro Phe Asp  Arg Glu Gln 
    2030                 2035                 2040             


Gln Glu  Ala Phe Asp Val Val  Val Glu Val Thr Glu  Glu His Lys 
    2045                 2050                 2055             


Pro Ser  Ala Val Ala His Val  Val Val Lys Val Ile  Val Glu Asp 
    2060                 2065                 2070             


Gln Asn  Asp Asn Ala Pro Val  Phe Val Asn Leu Pro  Tyr Tyr Ala 
    2075                 2080                 2085             


Val Val  Lys Val Asp Thr Glu  Val Gly His Val Ile  Arg Tyr Val 
    2090                 2095                 2100             


Thr Ala  Val Asp Arg Asp Ser  Gly Arg Asn Gly Glu  Val His Tyr 
    2105                 2110                 2115             


Tyr Leu  Lys Glu His His Glu  His Phe Gln Ile Gly  Pro Leu Gly 
    2120                 2125                 2130             


Glu Ile  Ser Leu Lys Lys Gln  Phe Glu Leu Asp Thr  Leu Asn Lys 
    2135                 2140                 2145             


Glu Tyr  Leu Val Thr Val Val  Ala Lys Asp Gly Gly  Asn Pro Ala 
    2150                 2155                 2160             


Phe Ser  Ala Glu Val Ile Val  Pro Ile Thr Val Met  Asn Lys Ala 
    2165                 2170                 2175             


Met Pro  Val Phe Glu Lys Pro  Phe Tyr Ser Ala Glu  Ile Ala Glu 
    2180                 2185                 2190             


Ser Ile  Gln Val His Ser Pro  Val Val His Val Gln  Ala Asn Ser 
    2195                 2200                 2205             


Pro Glu  Gly Leu Lys Val Phe  Tyr Ser Ile Thr Asp  Gly Asp Pro 
    2210                 2215                 2220             


Phe Ser  Gln Phe Thr Ile Asn  Phe Asn Thr Gly Val  Ile Asn Val 
    2225                 2230                 2235             


Ile Ala  Pro Leu Asp Phe Glu  Ala His Pro Ala Tyr  Lys Leu Ser 
    2240                 2245                 2250             


Ile Arg  Ala Thr Asp Ser Leu  Thr Gly Ala His Ala  Glu Val Phe 
    2255                 2260                 2265             


Val Asp  Ile Ile Val Asp Asp  Ile Asn Asp Asn Pro  Pro Val Phe 
    2270                 2275                 2280             


Ala Gln  Gln Ser Tyr Ala Val  Thr Leu Ser Glu Ala  Ser Val Ile 
    2285                 2290                 2295             


Gly Thr  Ser Val Val Gln Val  Arg Ala Thr Asp Ser  Asp Ser Glu 
    2300                 2305                 2310             


Pro Asn  Arg Gly Ile Ser Tyr  Gln Met Phe Gly Asn  His Ser Lys 
    2315                 2320                 2325             


Ser His  Asp His Phe His Val  Asp Ser Ser Thr Gly  Leu Ile Ser 
    2330                 2335                 2340             


Leu Leu  Arg Thr Leu Asp Tyr  Glu Gln Ser Arg Gln  His Thr Ile 
    2345                 2350                 2355             


Phe Val  Arg Ala Val Asp Gly  Gly Met Pro Thr Leu  Ser Ser Asp 
    2360                 2365                 2370             


Val Ile  Val Thr Val Asp Val  Thr Asp Leu Asn Asp  Asn Pro Pro 
    2375                 2380                 2385             


Leu Phe  Glu Gln Gln Ile Tyr  Glu Ala Arg Ile Ser  Glu His Ala 
    2390                 2395                 2400             


Pro His  Gly His Phe Val Thr  Cys Val Lys Ala Tyr  Asp Ala Asp 
    2405                 2410                 2415             


Ser Ser  Asp Ile Asp Lys Leu  Gln Tyr Ser Ile Leu  Ser Gly Asn 
    2420                 2425                 2430             


Asp His  Lys His Phe Val Ile  Asp Ser Ala Thr Gly  Ile Ile Thr 
    2435                 2440                 2445             


Leu Ser  Asn Leu His Arg His  Ala Leu Lys Pro Phe  Tyr Ser Leu 
    2450                 2455                 2460             


Asn Leu  Ser Val Ser Asp Gly  Val Phe Arg Ser Ser  Thr Gln Val 
    2465                 2470                 2475             


His Val  Thr Val Ile Gly Gly  Asn Leu His Ser Pro  Ala Phe Leu 
    2480                 2485                 2490             


Gln Asn  Glu Tyr Glu Val Glu  Leu Ala Glu Asn Ala  Pro Leu His 
    2495                 2500                 2505             


Thr Leu  Val Met Glu Val Lys  Thr Thr Asp Gly Asp  Ser Gly Ile 
    2510                 2515                 2520             


Tyr Gly  His Val Thr Tyr His  Ile Val Asn Asp Phe  Ala Lys Asp 
    2525                 2530                 2535             


Arg Phe  Tyr Ile Asn Glu Arg  Gly Gln Ile Phe Thr  Leu Glu Lys 
    2540                 2545                 2550             


Leu Asp  Arg Glu Thr Pro Ala  Glu Lys Val Ile Ser  Val Arg Leu 
    2555                 2560                 2565             


Met Ala  Lys Asp Ala Gly Gly  Lys Val Ala Phe Cys  Thr Val Asn 
    2570                 2575                 2580             


Val Ile  Leu Thr Asp Asp Asn  Asp Asn Ala Pro Gln  Phe Arg Ala 
    2585                 2590                 2595             


Thr Lys  Tyr Glu Val Asn Ile  Gly Ser Ser Ala Ala  Lys Gly Thr 
    2600                 2605                 2610             


Ser Val  Val Lys Val Leu Ala  Ser Asp Ala Asp Glu  Gly Ser Asn 
    2615                 2620                 2625             


Ala Asp  Ile Thr Tyr Ala Ile  Glu Ala Asp Ser Glu  Ser Val Lys 
    2630                 2635                 2640             


Glu Asn  Leu Glu Ile Asn Lys  Leu Ser Gly Val Ile  Thr Thr Lys 
    2645                 2650                 2655             


Glu Ser  Leu Ile Gly Leu Glu  Asn Glu Phe Phe Thr  Phe Phe Val 
    2660                 2665                 2670             


Arg Ala  Val Asp Asn Gly Ser  Pro Ser Lys Glu Ser  Val Val Leu 
    2675                 2680                 2685             


Val Tyr  Val Lys Ile Leu Pro  Pro Glu Met Gln Leu  Pro Lys Phe 
    2690                 2695                 2700             


Ser Glu  Pro Phe Tyr Thr Phe  Thr Val Ser Glu Asp  Val Pro Ile 
    2705                 2710                 2715             


Gly Thr  Glu Ile Asp Leu Ile  Arg Ala Glu His Ser  Gly Thr Val 
    2720                 2725                 2730             


Leu Tyr  Ser Leu Val Lys Gly  Asn Thr Pro Glu Ser  Asn Arg Asp 
    2735                 2740                 2745             


Glu Ser  Phe Val Ile Asp Arg  Gln Ser Gly Arg Leu  Lys Leu Glu 
    2750                 2755                 2760             


Lys Ser  Leu Asp His Glu Thr  Thr Lys Trp Tyr Gln  Phe Ser Ile 
    2765                 2770                 2775             


Leu Ala  Arg Cys Thr Gln Asp  Asp His Glu Met Val  Ala Ser Val 
    2780                 2785                 2790             


Asp Val  Ser Ile Gln Val Lys  Asp Ala Asn Asp Asn  Ser Pro Val 
    2795                 2800                 2805             


Phe Glu  Ser Ser Pro Tyr Glu  Ala Phe Ile Val Glu  Asn Leu Pro 
    2810                 2815                 2820             


Gly Gly  Ser Arg Val Ile Gln  Ile Arg Ala Ser Asp  Ala Asp Ser 
    2825                 2830                 2835             


Gly Thr  Asn Gly Gln Val Met  Tyr Ser Leu Asp Gln  Ser Gln Ser 
    2840                 2845                 2850             


Val Glu  Val Ile Glu Ser Phe  Ala Ile Asn Met Glu  Thr Gly Trp 
    2855                 2860                 2865             


Ile Thr  Thr Leu Lys Glu Leu  Asp His Glu Lys Arg  Asp Asn Tyr 
    2870                 2875                 2880             


Gln Ile  Lys Val Val Ala Ser  Asp His Gly Glu Lys  Ile Gln Leu 
    2885                 2890                 2895             


Ser Ser  Thr Ala Ile Val Asp  Val Thr Val Thr Asp  Val Asn Asp 
    2900                 2905                 2910             


Ser Pro  Pro Arg Phe Thr Ala  Glu Ile Tyr Lys Gly  Thr Val Ser 
    2915                 2920                 2925             


Glu Asp  Asp Pro Gln Gly Gly  Val Ile Ala Ile Leu  Ser Thr Thr 
    2930                 2935                 2940             


Asp Ala  Asp Ser Glu Glu Ile  Asn Arg Gln Val Thr  Tyr Phe Ile 
    2945                 2950                 2955             


Thr Gly  Gly Asp Pro Leu Gly  Gln Phe Ala Val Glu  Thr Ile Gln 
    2960                 2965                 2970             


Asn Glu  Trp Lys Val Tyr Val  Lys Lys Pro Leu Asp  Arg Glu Lys 
    2975                 2980                 2985             


Arg Asp  Asn Tyr Leu Leu Thr  Ile Thr Ala Thr Asp  Gly Thr Phe 
    2990                 2995                 3000             


Ser Ser  Lys Ala Ile Val Glu  Val Lys Val Leu Asp  Ala Asn Asp 
    3005                 3010                 3015             


Asn Ser  Pro Val Cys Glu Lys  Thr Leu Tyr Ser Asp  Thr Ile Pro 
    3020                 3025                 3030             


Glu Asp  Val Leu Pro Gly Lys  Leu Ile Met Gln Ile  Ser Ala Thr 
    3035                 3040                 3045             


Asp Ala  Asp Ile Arg Ser Asn  Ala Glu Ile Thr Tyr  Thr Leu Leu 
    3050                 3055                 3060             


Gly Ser  Gly Ala Glu Lys Phe  Lys Leu Asn Pro Asp  Thr Gly Glu 
    3065                 3070                 3075             


Leu Lys  Thr Ser Thr Pro Leu  Asp Arg Glu Glu Gln  Ala Val Tyr 
    3080                 3085                 3090             


His Leu  Leu Val Arg Ala Thr  Asp Gly Gly Gly Arg  Phe Cys Gln 
    3095                 3100                 3105             


Ala Ser  Ile Val Leu Thr Leu  Glu Asp Val Asn Asp  Asn Ala Pro 
    3110                 3115                 3120             


Glu Phe  Ser Ala Asp Pro Tyr  Ala Ile Thr Val Phe  Glu Asn Thr 
    3125                 3130                 3135             


Glu Pro  Gly Thr Leu Leu Thr  Arg Val Gln Ala Thr  Asp Ala Asp 
    3140                 3145                 3150             


Ala Gly  Leu Asn Arg Lys Ile  Leu Tyr Ser Leu Ile  Asp Ser Ala 
    3155                 3160                 3165             


Asp Gly  Gln Phe Ser Ile Asn  Glu Leu Ser Gly Ile  Ile Gln Leu 
    3170                 3175                 3180             


Glu Lys  Pro Leu Asp Arg Glu  Leu Gln Ala Val Tyr  Thr Leu Ser 
    3185                 3190                 3195             


Leu Lys  Ala Val Asp Gln Gly  Leu Pro Arg Arg Leu  Thr Ala Thr 
    3200                 3205                 3210             


Gly Thr  Val Ile Val Ser Val  Leu Asp Ile Asn Asp  Asn Pro Pro 
    3215                 3220                 3225             


Val Phe  Glu Tyr Arg Glu Tyr  Gly Ala Thr Val Ser  Glu Asp Ile 
    3230                 3235                 3240             


Leu Val  Gly Thr Glu Val Leu  Gln Val Tyr Ala Ala  Ser Arg Asp 
    3245                 3250                 3255             


Ile Glu  Ala Asn Ala Glu Ile  Thr Tyr Ser Ile Ile  Ser Gly Asn 
    3260                 3265                 3270             


Glu His  Gly Lys Phe Ser Ile  Asp Ser Lys Thr Gly  Ala Val Phe 
    3275                 3280                 3285             


Ile Ile  Glu Asn Leu Asp Tyr  Glu Ser Ser His Glu  Tyr Tyr Leu 
    3290                 3295                 3300             


Thr Val  Glu Ala Thr Asp Gly  Gly Thr Pro Ser Leu  Ser Asp Val 
    3305                 3310                 3315             


Ala Thr  Val Asn Val Asn Val  Thr Asp Ile Asn Asp  Asn Thr Pro 
    3320                 3325                 3330             


Val Phe  Ser Gln Asp Thr Tyr  Thr Thr Val Ile Ser  Glu Asp Ala 
    3335                 3340                 3345             


Val Leu  Glu Gln Ser Val Ile  Thr Val Met Ala Asp  Asp Ala Asp 
    3350                 3355                 3360             


Gly Pro  Ser Asn Ser His Ile  His Tyr Ser Ile Ile  Asp Gly Asn 
    3365                 3370                 3375             


Gln Gly  Ser Ser Phe Thr Ile  Asp Pro Val Arg Gly  Glu Val Lys 
    3380                 3385                 3390             


Val Thr  Lys Leu Leu Asp Arg  Glu Thr Ile Ser Gly  Tyr Thr Leu 
    3395                 3400                 3405             


Thr Val  Gln Ala Ser Asp Asn  Gly Ser Pro Pro Arg  Val Asn Thr 
    3410                 3415                 3420             


Thr Thr  Val Asn Ile Asp Val  Ser Asp Val Asn Asp  Asn Ala Pro 
    3425                 3430                 3435             


Val Phe  Ser Arg Gly Asn Tyr  Ser Val Ile Ile Gln  Glu Asn Lys 
    3440                 3445                 3450             


Pro Val  Gly Phe Ser Val Leu  Gln Leu Val Val Thr  Asp Glu Asp 
    3455                 3460                 3465             


Ser Ser  His Asn Gly Pro Pro  Phe Phe Phe Thr Ile  Val Thr Gly 
    3470                 3475                 3480             


Asn Asp  Glu Lys Ala Phe Glu  Val Asn Pro Gln Gly  Val Leu Leu 
    3485                 3490                 3495             


Thr Ser  Ser Ala Ile Lys Arg  Lys Glu Lys Asp His  Tyr Leu Leu 
    3500                 3505                 3510             


Gln Val  Lys Val Ala Asp Asn  Gly Lys Pro Gln Leu  Ser Ser Leu 
    3515                 3520                 3525             


Thr Tyr  Ile Asp Ile Arg Val  Ile Glu Glu Ser Ile  Tyr Pro Pro 
    3530                 3535                 3540             


Ala Ile  Leu Pro Leu Glu Ile  Phe Ile Thr Ser Ser  Gly Glu Glu 
    3545                 3550                 3555             


Tyr Ser  Gly Gly Val Ile Gly  Lys Ile His Ala Thr  Asp Gln Asp 
    3560                 3565                 3570             


Val Tyr  Asp Thr Leu Thr Tyr  Ser Leu Asp Pro Gln  Met Asp Asn 
    3575                 3580                 3585             


Leu Phe  Ser Val Ser Ser Thr  Gly Gly Lys Leu Ile  Ala His Lys 
    3590                 3595                 3600             


Lys Leu  Asp Ile Gly Gln Tyr  Leu Leu Asn Val Ser  Val Thr Asp 
    3605                 3610                 3615             


Gly Lys  Phe Thr Thr Val Ala  Asp Ile Thr Val His  Ile Arg Gln 
    3620                 3625                 3630             


Val Thr  Gln Glu Met Leu Asn  His Thr Ile Ala Ile  Arg Phe Ala 
    3635                 3640                 3645             


Asn Leu  Thr Pro Glu Glu Phe  Val Gly Asp Tyr Trp  Arg Asn Phe 
    3650                 3655                 3660             


Gln Arg  Ala Leu Arg Asn Ile  Leu Gly Val Arg Arg  Asn Asp Ile 
    3665                 3670                 3675             


Gln Ile  Val Ser Leu Gln Ser  Ser Glu Pro His Pro  His Leu Asp 
    3680                 3685                 3690             


Val Leu  Leu Phe Val Glu Lys  Pro Gly Ser Ala Gln  Ile Ser Thr 
    3695                 3700                 3705             


Lys Gln  Leu Leu His Lys Ile  Asn Ser Ser Val Thr  Asp Ile Glu 
    3710                 3715                 3720             


Glu Ile  Ile Gly Val Arg Ile  Leu Asn Val Phe Gln  Lys Leu Cys 
    3725                 3730                 3735             


Ala Gly  Leu Asp Cys Pro Trp  Lys Phe Cys Asp Glu  Lys Val Ser 
    3740                 3745                 3750             


Val Asp  Glu Ser Val Met Ser  Thr His Ser Thr Ala  Arg Leu Ser 
    3755                 3760                 3765             


Phe Val  Thr Pro Arg His His  Arg Ala Ala Val Cys  Leu Cys Lys 
    3770                 3775                 3780             


Glu Gly  Arg Cys Pro Pro Val  His His Gly Cys Glu  Asp Asp Pro 
    3785                 3790                 3795             


Cys Pro  Glu Gly Ser Glu Cys  Val Ser Asp Pro Trp  Glu Glu Lys 
    3800                 3805                 3810             


His Thr  Cys Val Cys Pro Ser  Gly Arg Phe Gly Gln  Cys Pro Gly 
    3815                 3820                 3825             


Ser Ser  Ser Met Thr Leu Thr  Gly Asn Ser Tyr Val  Lys Tyr Arg 
    3830                 3835                 3840             


Leu Thr  Glu Asn Glu Asn Lys  Leu Glu Met Lys Leu  Thr Met Arg 
    3845                 3850                 3855             


Leu Arg  Thr Tyr Ser Thr His  Ala Val Val Met Tyr  Ala Arg Gly 
    3860                 3865                 3870             


Thr Asp  Tyr Ser Ile Leu Glu  Ile His His Gly Arg  Leu Gln Tyr 
    3875                 3880                 3885             


Lys Phe  Asp Cys Gly Ser Gly  Pro Gly Ile Val Ser  Val Gln Ser 
    3890                 3895                 3900             


Ile Gln  Val Asn Asp Gly Gln  Trp His Ala Val Ala  Leu Glu Val 
    3905                 3910                 3915             


Asn Gly  Asn Tyr Ala Arg Leu  Val Leu Asp Gln Val  His Thr Ala 
    3920                 3925                 3930             


Ser Gly  Thr Ala Pro Gly Thr  Leu Lys Thr Leu Asn  Leu Asp Asn 
    3935                 3940                 3945             


Tyr Val  Phe Phe Gly Gly His  Ile Arg Gln Gln Gly  Thr Arg His 
    3950                 3955                 3960             


Gly Arg  Ser Pro Gln Val Gly  Asn Gly Phe Arg Gly  Cys Met Asp 
    3965                 3970                 3975             


Ser Ile  Tyr Leu Asn Gly Gln  Glu Leu Pro Leu Asn  Ser Lys Pro 
    3980                 3985                 3990             


Arg Ser  Tyr Ala His Ile Glu  Glu Ser Val Asp Val  Ser Pro Gly 
    3995                 4000                 4005             


Cys Phe  Leu Thr Ala Thr Glu  Asp Cys Ala Ser Asn  Pro Cys Gln 
    4010                 4015                 4020             


Asn Gly  Gly Val Cys Asn Pro  Ser Pro Ala Gly Gly  Tyr Tyr Cys 
    4025                 4030                 4035             


Lys Cys  Ser Ala Leu Tyr Ile  Gly Thr His Cys Glu  Ile Ser Val 
    4040                 4045                 4050             


Asn Pro  Cys Ser Ser Lys Pro  Cys Leu Tyr Gly Gly  Thr Cys Val 
    4055                 4060                 4065             


Val Asp  Asn Gly Gly Phe Val  Cys Gln Cys Arg Gly  Leu Tyr Thr 
    4070                 4075                 4080             


Gly Gln  Arg Cys Gln Leu Ser  Pro Tyr Cys Lys Asp  Glu Pro Cys 
    4085                 4090                 4095             


Lys Asn  Gly Gly Thr Cys Phe  Asp Ser Leu Asp Gly  Ala Val Cys 
    4100                 4105                 4110             


Gln Cys  Asp Ser Gly Phe Arg  Gly Glu Arg Cys Gln  Ser Asp Ile 
    4115                 4120                 4125             


Asp Glu  Cys Ser Gly Asn Pro  Cys Leu His Gly Ala  Leu Cys Glu 
    4130                 4135                 4140             


Asn Thr  His Gly Ser Tyr His  Cys Asn Cys Ser His  Glu Tyr Arg 
    4145                 4150                 4155             


Gly Arg  His Cys Glu Asp Ala  Ala Pro Asn Gln Tyr  Val Ser Thr 
    4160                 4165                 4170             


Pro Trp  Asn Ile Gly Leu Ala  Glu Gly Ile Gly Ile  Val Val Phe 
    4175                 4180                 4185             


Val Ala  Gly Ile Phe Leu Leu  Val Val Val Phe Val  Leu Cys Arg 
    4190                 4195                 4200             


Lys Met  Ile Ser Arg Lys Lys  Lys His Gln Ala Glu  Pro Lys Asp 
    4205                 4210                 4215             


Lys His  Leu Gly Pro Ala Thr  Ala Phe Leu Gln Arg  Pro Tyr Phe 
    4220                 4225                 4230             


Asp Ser  Lys Leu Asn Lys Asn  Ile Tyr Ser Asp Ile  Pro Pro Gln 
    4235                 4240                 4245             


Val Pro  Val Arg Pro Ile Ser  Tyr Thr Pro Ser Ile  Pro Ser Asp 
    4250                 4255                 4260             


Ser Arg  Asn Asn Leu Asp Arg  Asn Ser Phe Glu Gly  Ser Ala Ile 
    4265                 4270                 4275             


Pro Glu  His Pro Glu Phe Ser  Thr Phe Asn Pro Glu  Ser Val His 
    4280                 4285                 4290             


Gly His  Arg Lys Ala Val Ala  Val Cys Ser Val Ala  Pro Asn Leu 
    4295                 4300                 4305             


Pro Pro  Pro Pro Pro Ser Asn  Ser Pro Ser Asp Ser  Asp Ser Ile 
    4310                 4315                 4320             


Gln Lys  Pro Ser Trp Asp Phe  Asp Tyr Asp Thr Lys  Val Val Asp 
    4325                 4330                 4335             


Leu Asp  Pro Cys Leu Ser Lys  Lys Pro Leu Glu Glu  Lys Pro Ser 
    4340                 4345                 4350             


Gln Pro  Tyr Ser Ala Arg Glu  Ser Leu Ser Glu Val  Gln Ser Leu 
    4355                 4360                 4365             


Ser Ser  Phe Gln Ser Glu Ser  Cys Asp Asp Asn Gly  Tyr His Trp 
    4370                 4375                 4380             


Asp Thr  Ser Asp Trp Met Pro  Ser Val Pro Leu Pro  Asp Ile Gln 
    4385                 4390                 4395             


Glu Phe  Pro Asn Tyr Glu Val  Ile Asp Glu Gln Thr  Pro Leu Tyr 
    4400                 4405                 4410             


Ser Ala  Asp Pro Asn Ala Ile  Asp Thr Asp Tyr Tyr  Pro Gly Gly 
    4415                 4420                 4425             


Tyr Asp  Ile Glu Ser Asp Phe  Pro Pro Pro Pro Glu  Asp Phe Pro 
    4430                 4435                 4440             


Ala Ala  Asp Glu Leu Pro Pro  Leu Pro Pro Glu Phe  Ser Asn Gln 
    4445                 4450                 4455             


Phe Glu  Ser Ile His Pro Pro  Arg Asp Met Pro Ala  Ala Gly Ser 
    4460                 4465                 4470             


Leu Gly  Ser Ser Ser Arg Asn  Arg Gln Arg Phe Asn  Leu Asn Gln 
    4475                 4480                 4485             


Tyr Leu  Pro Asn Phe Tyr Pro  Leu Asp Met Ser Glu  Pro Gln Thr 
    4490                 4495                 4500             


Lys Gly  Thr Gly Glu Asn Ser  Thr Cys Arg Glu Pro  His Ala Pro 
    4505                 4510                 4515             


Tyr Pro  Pro Gly Tyr Gln Arg  His Phe Glu Ala Pro  Ala Val Glu 
    4520                 4525                 4530             


Ser Met  Pro Met Ser Val Tyr  Ala Ser Thr Ala Ser  Cys Ser Asp 
    4535                 4540                 4545             


Val Ser  Ala Cys Cys Glu Val  Glu Ser Glu Val Met  Met Ser Asp 
    4550                 4555                 4560             


Tyr Glu  Ser Gly Asp Asp Gly  His Phe Glu Glu Val  Thr Ile Pro 
    4565                 4570                 4575             


Pro Leu  Asp Ser Gln Gln His  Thr Glu Val 
    4580                 4585             


<210>  5116
<211>  488
<212>  PRT
<213>  Homo Sapiens

<400>  5116

Met Gly Arg His Leu Ala Leu Leu Leu Leu Leu Leu Leu Leu Phe Gln 
1               5                   10                  15      


His Phe Gly Asp Ser Asp Gly Ser Gln Arg Leu Glu Gln Thr Pro Leu 
            20                  25                  30          


Gln Phe Thr His Leu Glu Tyr Asn Val Thr Val Gln Glu Asn Ser Ala 
        35                  40                  45              


Ala Lys Thr Tyr Val Gly His Pro Val Lys Met Gly Val Tyr Ile Thr 
    50                  55                  60                  


His Pro Ala Trp Glu Val Arg Tyr Lys Ile Val Ser Gly Asp Ser Glu 
65                  70                  75                  80  


Asn Leu Phe Lys Ala Glu Glu Tyr Ile Leu Gly Asp Phe Cys Phe Leu 
                85                  90                  95      


Arg Ile Arg Thr Lys Gly Gly Asn Thr Ala Ile Leu Asn Arg Glu Val 
            100                 105                 110         


Lys Asp His Tyr Thr Leu Ile Val Lys Ala Leu Glu Lys Asn Thr Asn 
        115                 120                 125             


Val Glu Ala Arg Thr Lys Val Arg Val Gln Val Leu Asp Thr Asn Asp 
    130                 135                 140                 


Leu Arg Pro Leu Phe Ser Pro Thr Ser Tyr Ser Val Ser Leu Pro Glu 
145                 150                 155                 160 


Asn Thr Ala Ile Arg Thr Ser Ile Ala Arg Val Ser Ala Thr Asp Ala 
                165                 170                 175     


Asp Ile Gly Thr Asn Gly Glu Phe Tyr Tyr Ser Phe Lys Asp Arg Thr 
            180                 185                 190         


Asp Met Phe Ala Ile His Pro Thr Ser Gly Val Ile Val Leu Thr Gly 
        195                 200                 205             


Arg Leu Asp Tyr Leu Glu Thr Lys Leu Tyr Glu Met Glu Ile Leu Ala 
    210                 215                 220                 


Ala Asp Arg Gly Met Lys Leu Tyr Gly Ser Ser Gly Ile Ser Ser Met 
225                 230                 235                 240 


Ala Lys Leu Thr Val His Ile Glu Gln Ala Asn Glu Cys Ala Pro Val 
                245                 250                 255     


Ile Thr Ala Val Thr Leu Ser Pro Ser Glu Leu Asp Arg Asp Pro Ala 
            260                 265                 270         


Tyr Ala Ile Val Thr Val Asp Asp Cys Asp Gln Gly Ala Asn Gly Asp 
        275                 280                 285             


Ile Ala Ser Leu Ser Ile Val Ala Gly Asp Leu Leu Gln Gln Phe Arg 
    290                 295                 300                 


Thr Val Arg Ser Phe Pro Gly Ser Lys Glu Tyr Lys Val Lys Ala Ile 
305                 310                 315                 320 


Gly Gly Ile Asp Trp Asp Ser His Pro Phe Gly Tyr Asn Leu Thr Leu 
                325                 330                 335     


Gln Ala Lys Asp Lys Gly Thr Pro Pro Gln Phe Ser Ser Val Lys Val 
            340                 345                 350         


Ile His Val Thr Ser Pro Gln Phe Lys Ala Gly Pro Val Lys Phe Glu 
        355                 360                 365             


Lys Asp Val Tyr Arg Ala Glu Ile Ser Glu Phe Ala Pro Pro Asn Thr 
    370                 375                 380                 


Pro Val Val Met Val Lys Ala Ile Pro Ala Tyr Ser His Leu Arg Tyr 
385                 390                 395                 400 


Val Phe Lys Ser Thr Pro Gly Lys Ala Lys Phe Ser Leu Asn Tyr Asn 
                405                 410                 415     


Thr Gly Leu Ile Ser Ile Leu Glu Pro Val Lys Arg Gln Gln Ala Ala 
            420                 425                 430         


His Phe Glu Leu Glu Val Thr Thr Ser Asp Arg Lys Ala Ser Thr Lys 
        435                 440                 445             


Val Leu Val Lys Val Leu Gly Ala Asn Ser Asn Pro Pro Glu Phe Thr 
    450                 455                 460                 


Gln Thr Ala Tyr Lys Ala Ala Phe Asp Glu Asn Val Pro Ile Gly Thr 
465                 470                 475                 480 


Thr Val Met Ser Leu Ser Ala Val 
                485             


<210>  5117
<211>  4590
<212>  PRT
<213>  Homo Sapiens

<400>  5117

Met Gly Arg His Leu Ala Leu Leu Leu Leu Leu Leu Leu Leu Phe Gln 
1               5                   10                  15      


His Phe Gly Asp Ser Asp Gly Ser Gln Arg Leu Glu Gln Thr Pro Leu 
            20                  25                  30          


Gln Phe Thr His Leu Glu Tyr Asn Val Thr Val Gln Glu Asn Ser Ala 
        35                  40                  45              


Ala Lys Thr Tyr Val Gly His Pro Val Lys Met Gly Val Tyr Ile Thr 
    50                  55                  60                  


His Pro Ala Trp Glu Val Arg Tyr Lys Ile Val Ser Gly Asp Ser Glu 
65                  70                  75                  80  


Asn Leu Phe Lys Ala Glu Glu Tyr Ile Leu Gly Asp Phe Cys Phe Leu 
                85                  90                  95      


Arg Ile Arg Thr Lys Gly Gly Asn Thr Ala Ile Leu Asn Arg Glu Val 
            100                 105                 110         


Lys Asp His Tyr Thr Leu Ile Val Lys Ala Leu Glu Lys Asn Thr Asn 
        115                 120                 125             


Val Glu Ala Arg Thr Lys Val Arg Val Gln Val Leu Asp Thr Asn Asp 
    130                 135                 140                 


Leu Arg Pro Leu Phe Ser Pro Thr Ser Tyr Ser Val Ser Leu Pro Glu 
145                 150                 155                 160 


Asn Thr Ala Ile Arg Thr Ser Ile Ala Arg Val Ser Ala Thr Asp Ala 
                165                 170                 175     


Asp Ile Gly Thr Asn Gly Glu Phe Tyr Tyr Ser Phe Lys Asp Arg Thr 
            180                 185                 190         


Asp Met Phe Ala Ile His Pro Thr Ser Gly Val Ile Val Leu Thr Gly 
        195                 200                 205             


Arg Leu Asp Tyr Leu Glu Thr Lys Leu Tyr Glu Met Glu Ile Leu Ala 
    210                 215                 220                 


Ala Asp Arg Gly Met Lys Leu Tyr Gly Ser Ser Gly Ile Ser Ser Met 
225                 230                 235                 240 


Ala Lys Leu Thr Val His Ile Glu Gln Ala Asn Glu Cys Ala Pro Val 
                245                 250                 255     


Ile Thr Ala Val Thr Leu Ser Pro Ser Glu Leu Asp Arg Asp Pro Ala 
            260                 265                 270         


Tyr Ala Ile Val Thr Val Asp Asp Cys Asp Gln Gly Ala Asn Gly Asp 
        275                 280                 285             


Ile Ala Ser Leu Ser Ile Val Ala Gly Asp Leu Leu Gln Gln Phe Arg 
    290                 295                 300                 


Thr Val Arg Ser Phe Pro Gly Ser Lys Glu Tyr Lys Val Lys Ala Ile 
305                 310                 315                 320 


Gly Gly Ile Asp Trp Asp Ser His Pro Phe Gly Tyr Asn Leu Thr Leu 
                325                 330                 335     


Gln Ala Lys Asp Lys Gly Thr Pro Pro Gln Phe Ser Ser Val Lys Val 
            340                 345                 350         


Ile His Val Thr Ser Pro Gln Phe Lys Ala Gly Pro Val Lys Phe Glu 
        355                 360                 365             


Lys Asp Val Tyr Arg Ala Glu Ile Ser Glu Phe Ala Pro Pro Asn Thr 
    370                 375                 380                 


Pro Val Val Met Val Lys Ala Ile Pro Ala Tyr Ser His Leu Arg Tyr 
385                 390                 395                 400 


Val Phe Lys Ser Thr Pro Gly Lys Ala Lys Phe Ser Leu Asn Tyr Asn 
                405                 410                 415     


Thr Gly Leu Ile Ser Ile Leu Glu Pro Val Lys Arg Gln Gln Ala Ala 
            420                 425                 430         


His Phe Glu Leu Glu Val Thr Thr Ser Asp Arg Lys Ala Ser Thr Lys 
        435                 440                 445             


Val Leu Val Lys Val Leu Gly Ala Asn Ser Asn Pro Pro Glu Phe Thr 
    450                 455                 460                 


Gln Thr Ala Tyr Lys Ala Ala Phe Asp Glu Asn Val Pro Ile Gly Thr 
465                 470                 475                 480 


Thr Val Met Ser Leu Ser Ala Val Asp Pro Asp Glu Gly Glu Asn Gly 
                485                 490                 495     


Tyr Val Thr Tyr Ser Ile Ala Asn Leu Asn His Val Pro Phe Ala Ile 
            500                 505                 510         


Asp His Phe Thr Gly Ala Val Ser Thr Ser Glu Asn Leu Asp Tyr Glu 
        515                 520                 525             


Leu Met Pro Arg Val Tyr Thr Leu Arg Ile Arg Ala Ser Asp Trp Gly 
    530                 535                 540                 


Leu Pro Tyr Arg Arg Glu Val Glu Val Leu Ala Thr Ile Thr Leu Asn 
545                 550                 555                 560 


Asn Leu Asn Asp Asn Thr Pro Leu Phe Glu Lys Ile Asn Cys Glu Gly 
                565                 570                 575     


Thr Ile Pro Arg Asp Leu Gly Val Gly Glu Gln Ile Thr Thr Val Ser 
            580                 585                 590         


Ala Ile Asp Ala Asp Glu Leu Gln Leu Val Gln Tyr Gln Ile Glu Ala 
        595                 600                 605             


Gly Asn Glu Leu Asp Phe Phe Ser Leu Asn Pro Asn Ser Gly Val Leu 
    610                 615                 620                 


Ser Leu Lys Arg Ser Leu Met Asp Gly Leu Gly Ala Lys Val Ser Phe 
625                 630                 635                 640 


His Ser Leu Arg Ile Thr Ala Thr Asp Gly Glu Asn Phe Ala Thr Pro 
                645                 650                 655     


Leu Tyr Ile Asn Ile Thr Val Ala Ala Ser His Lys Leu Val Asn Leu 
            660                 665                 670         


Gln Cys Glu Glu Thr Gly Val Ala Lys Met Leu Ala Glu Lys Leu Leu 
        675                 680                 685             


Gln Ala Asn Lys Leu His Asn Gln Gly Glu Val Glu Asp Ile Phe Phe 
    690                 695                 700                 


Asp Ser His Ser Val Asn Ala His Ile Pro Gln Phe Arg Ser Thr Leu 
705                 710                 715                 720 


Pro Thr Gly Ile Gln Val Lys Glu Asn Gln Pro Val Gly Ser Ser Val 
                725                 730                 735     


Ile Phe Met Asn Ser Thr Asp Leu Asp Thr Gly Phe Asn Gly Lys Leu 
            740                 745                 750         


Val Tyr Ala Val Ser Gly Gly Asn Glu Asp Ser Cys Phe Met Ile Asp 
        755                 760                 765             


Met Glu Thr Gly Met Leu Lys Ile Leu Ser Pro Leu Asp Arg Glu Thr 
    770                 775                 780                 


Thr Asp Lys Tyr Thr Leu Asn Ile Thr Val Tyr Asp Leu Gly Ile Pro 
785                 790                 795                 800 


Gln Lys Ala Ala Trp Arg Leu Leu His Val Val Val Val Asp Ala Asn 
                805                 810                 815     


Asp Asn Pro Pro Glu Phe Leu Gln Glu Ser Tyr Phe Val Glu Val Ser 
            820                 825                 830         


Glu Asp Lys Glu Val His Ser Glu Ile Ile Gln Val Glu Ala Thr Asp 
        835                 840                 845             


Lys Asp Leu Gly Pro Asn Gly His Val Thr Tyr Ser Ile Val Thr Asp 
    850                 855                 860                 


Thr Asp Thr Phe Ser Ile Asp Ser Val Thr Gly Val Val Asn Ile Ala 
865                 870                 875                 880 


Arg Pro Leu Asp Arg Glu Leu Gln His Glu His Ser Leu Lys Ile Glu 
                885                 890                 895     


Ala Arg Asp Gln Ala Arg Glu Glu Pro Gln Leu Phe Ser Thr Val Val 
            900                 905                 910         


Val Lys Val Ser Leu Glu Asp Val Asn Asp Asn Pro Pro Thr Phe Ile 
        915                 920                 925             


Pro Pro Asn Tyr Arg Val Lys Val Arg Glu Asp Leu Pro Glu Gly Thr 
    930                 935                 940                 


Val Ile Met Trp Leu Glu Ala His Asp Pro Asp Leu Gly Gln Ser Gly 
945                 950                 955                 960 


Gln Val Arg Tyr Ser Leu Leu Asp His Gly Glu Gly Asn Phe Asp Val 
                965                 970                 975     


Asp Lys Leu Ser Gly Ala Val Arg Ile Val Gln Gln Leu Asp Phe Glu 
            980                 985                 990         


Lys Lys Gln Val Tyr Asn Leu Thr  Val Arg Ala Lys Asp  Lys Gly Lys 
        995                 1000                 1005             


Pro Val  Ser Leu Ser Ser Thr  Cys Tyr Val Glu Val  Glu Val Val 
    1010                 1015                 1020             


Asp Val  Asn Glu Asn Leu His  Pro Pro Val Phe Ser  Ser Phe Val 
    1025                 1030                 1035             


Glu Lys  Gly Thr Val Lys Glu  Asp Ala Pro Val Gly  Ser Leu Val 
    1040                 1045                 1050             


Met Thr  Val Ser Ala His Asp  Glu Asp Ala Arg Arg  Asp Gly Glu 
    1055                 1060                 1065             


Ile Arg  Tyr Ser Ile Arg Asp  Gly Ser Gly Val Gly  Val Phe Lys 
    1070                 1075                 1080             


Ile Gly  Glu Glu Thr Gly Val  Ile Glu Thr Ser Asp  Arg Leu Asp 
    1085                 1090                 1095             


Arg Glu  Ser Thr Ser His Tyr  Trp Leu Thr Val Phe  Ala Thr Asp 
    1100                 1105                 1110             


Gln Gly  Val Val Pro Leu Ser  Ser Phe Ile Glu Ile  Tyr Ile Glu 
    1115                 1120                 1125             


Val Glu  Asp Val Asn Asp Asn  Ala Pro Gln Thr Ser  Glu Pro Val 
    1130                 1135                 1140             


Tyr Tyr  Pro Glu Ile Met Glu  Asn Ser Pro Lys Asp  Val Ser Val 
    1145                 1150                 1155             


Val Gln  Ile Glu Ala Phe Asp  Pro Asp Ser Ser Ser  Asn Asp Lys 
    1160                 1165                 1170             


Leu Met  Tyr Lys Ile Thr Ser  Gly Asn Pro Gln Gly  Phe Phe Ser 
    1175                 1180                 1185             


Ile His  Pro Lys Thr Gly Leu  Ile Thr Thr Thr Ser  Arg Lys Leu 
    1190                 1195                 1200             


Asp Arg  Glu Gln Gln Asp Glu  His Ile Leu Glu Val  Thr Val Thr 
    1205                 1210                 1215             


Asp Asn  Gly Ser Pro Pro Lys  Ser Thr Ile Ala Arg  Val Ile Val 
    1220                 1225                 1230             


Lys Ile  Leu Asp Glu Asn Asp  Asn Lys Pro Gln Phe  Leu Gln Lys 
    1235                 1240                 1245             


Phe Tyr  Lys Ile Arg Leu Pro  Glu Arg Glu Lys Pro  Asp Arg Glu 
    1250                 1255                 1260             


Arg Asn  Ala Arg Arg Glu Pro  Leu Tyr His Val Ile  Ala Thr Asp 
    1265                 1270                 1275             


Lys Asp  Glu Gly Pro Asn Ala  Glu Ile Ser Tyr Ser  Ile Glu Asp 
    1280                 1285                 1290             


Gly Asn  Glu His Gly Lys Phe  Phe Ile Glu Pro Lys  Thr Gly Val 
    1295                 1300                 1305             


Val Ser  Ser Lys Arg Phe Ser  Ala Ala Gly Glu Tyr  Asp Ile Leu 
    1310                 1315                 1320             


Ser Ile  Lys Ala Val Asp Asn  Gly Arg Pro Gln Lys  Ser Ser Thr 
    1325                 1330                 1335             


Thr Arg  Leu His Ile Glu Trp  Ile Ser Lys Pro Lys  Pro Ser Leu 
    1340                 1345                 1350             


Glu Pro  Ile Ser Phe Glu Glu  Ser Phe Phe Thr Phe  Thr Val Met 
    1355                 1360                 1365             


Glu Ser  Asp Pro Val Ala His  Met Ile Gly Val Ile  Ser Val Glu 
    1370                 1375                 1380             


Pro Pro  Gly Ile Pro Leu Trp  Phe Asp Ile Thr Gly  Gly Asn Tyr 
    1385                 1390                 1395             


Asp Ser  His Phe Asp Val Asp  Lys Gly Thr Gly Thr  Ile Ile Val 
    1400                 1405                 1410             


Ala Lys  Pro Leu Asp Ala Glu  Gln Lys Ser Asn Tyr  Asn Leu Thr 
    1415                 1420                 1425             


Val Glu  Ala Thr Asp Gly Thr  Thr Thr Ile Leu Thr  Gln Val Phe 
    1430                 1435                 1440             


Ile Lys  Val Ile Asp Thr Asn  Asp His Arg Pro Gln  Phe Ser Thr 
    1445                 1450                 1455             


Ser Lys  Tyr Glu Val Val Ile  Pro Glu Asp Thr Ala  Pro Glu Thr 
    1460                 1465                 1470             


Glu Ile  Leu Gln Ile Ser Ala  Val Asp Gln Asp Glu  Lys Asn Lys 
    1475                 1480                 1485             


Leu Ile  Tyr Thr Leu Gln Ser  Ser Arg Asp Pro Leu  Ser Leu Lys 
    1490                 1495                 1500             


Lys Phe  Arg Leu Asp Pro Ala  Thr Gly Ser Leu Tyr  Thr Ser Glu 
    1505                 1510                 1515             


Lys Leu  Asp His Glu Ala Val  Pro Ala His Leu Thr  Val Met Val 
    1520                 1525                 1530             


Arg Asp  Gln Asp Val Pro Val  Lys Arg Asn Phe Ala  Arg Ile Val 
    1535                 1540                 1545             


Val Asn  Val Ser Asp Thr Asn  Asp His Ala Pro Trp  Phe Thr Ala 
    1550                 1555                 1560             


Ser Ser  Tyr Lys Gly Arg Val  Tyr Glu Ser Ala Ala  Val Gly Ser 
    1565                 1570                 1575             


Val Val  Leu Gln Val Thr Ala  Leu Asp Lys Asp Lys  Gly Lys Asn 
    1580                 1585                 1590             


Ala Glu  Val Leu Tyr Ser Ile  Glu Ser Gly Thr Phe  Gly Asn Ile 
    1595                 1600                 1605             


Gly Asn  Ser Phe Met Ile Asp  Pro Val Leu Gly Ser  Ile Lys Thr 
    1610                 1615                 1620             


Ala Lys  Glu Leu Asp Arg Ser  Asn Gln Ala Glu Tyr  Asp Leu Met 
    1625                 1630                 1635             


Val Lys  Ala Thr Asp Lys Gly  Ser Pro Pro Met Ser  Glu Ile Thr 
    1640                 1645                 1650             


Ser Val  Arg Ile Phe Val Thr  Ile Ala Asp Asn Ala  Ser Pro Lys 
    1655                 1660                 1665             


Phe Thr  Ser Lys Glu Tyr Ser  Val Glu Leu Ser Glu  Thr Val Ser 
    1670                 1675                 1680             


Ile Gly  Ser Phe Val Gly Met  Val Thr Ala His Ser  Gln Ser Ser 
    1685                 1690                 1695             


Val Val  Tyr Glu Ile Lys Asp  Gly Asn Thr Gly Asp  Ala Phe Asp 
    1700                 1705                 1710             


Ile Asn  Pro His Ser Gly Thr  Ile Ile Thr Gln Lys  Ala Leu Asp 
    1715                 1720                 1725             


Phe Glu  Thr Leu Pro Ile Tyr  Thr Leu Ile Ile Gln  Gly Thr Asn 
    1730                 1735                 1740             


Met Ala  Gly Leu Ser Thr Asn  Thr Thr Val Leu Val  His Leu Gln 
    1745                 1750                 1755             


Asp Glu  Asn Asp Asn Ala Pro  Val Phe Met Gln Ala  Glu Tyr Thr 
    1760                 1765                 1770             


Gly Leu  Ile Ser Glu Ser Ala  Ser Ile Asn Ser Val  Val Leu Thr 
    1775                 1780                 1785             


Asp Arg  Asn Val Pro Leu Val  Ile Arg Ala Ala Asp  Ala Asp Lys 
    1790                 1795                 1800             


Asp Ser  Asn Ala Leu Leu Val  Tyr His Ile Val Glu  Pro Ser Val 
    1805                 1810                 1815             


His Thr  Tyr Phe Ala Ile Asp  Ser Ser Thr Gly Ala  Ile His Thr 
    1820                 1825                 1830             


Val Leu  Ser Leu Asp Tyr Glu  Glu Thr Ser Ile Phe  His Phe Thr 
    1835                 1840                 1845             


Val Gln  Val His Asp Met Gly  Thr Pro Arg Leu Phe  Ala Glu Tyr 
    1850                 1855                 1860             


Ala Ala  Asn Val Thr Val His  Val Ile Asp Ile Asn  Asp Cys Pro 
    1865                 1870                 1875             


Pro Val  Phe Ala Lys Pro Leu  Tyr Glu Ala Ser Leu  Leu Leu Pro 
    1880                 1885                 1890             


Thr Tyr  Lys Gly Val Lys Val  Ile Thr Val Asn Ala  Thr Asp Ala 
    1895                 1900                 1905             


Asp Ser  Ser Ala Phe Ser Gln  Leu Ile Tyr Ser Ile  Thr Glu Gly 
    1910                 1915                 1920             


Asn Ile  Gly Glu Lys Phe Ser  Met Asp Tyr Lys Thr  Gly Ala Leu 
    1925                 1930                 1935             


Thr Val  Gln Asn Thr Thr Gln  Leu Arg Ser Arg Tyr  Glu Leu Thr 
    1940                 1945                 1950             


Val Arg  Ala Ser Asp Gly Arg  Phe Ala Gly Leu Thr  Ser Val Lys 
    1955                 1960                 1965             


Ile Asn  Val Lys Glu Ser Lys  Glu Ser His Leu Lys  Phe Thr Gln 
    1970                 1975                 1980             


Asp Val  Tyr Ser Ala Val Val  Lys Glu Asn Ser Thr  Glu Ala Glu 
    1985                 1990                 1995             


Thr Leu  Ala Val Ile Thr Ala  Ile Gly Asn Pro Ile  Asn Glu Pro 
    2000                 2005                 2010             


Leu Phe  Tyr His Ile Leu Asn  Pro Asp Arg Arg Phe  Lys Ile Ser 
    2015                 2020                 2025             


Arg Thr  Ser Gly Val Leu Ser  Thr Thr Gly Thr Pro  Phe Asp Arg 
    2030                 2035                 2040             


Glu Gln  Gln Glu Ala Phe Asp  Val Val Val Glu Val  Thr Glu Glu 
    2045                 2050                 2055             


His Lys  Pro Ser Ala Val Ala  His Val Val Val Lys  Val Ile Val 
    2060                 2065                 2070             


Glu Asp  Gln Asn Asp Asn Ala  Pro Val Phe Val Asn  Leu Pro Tyr 
    2075                 2080                 2085             


Tyr Ala  Val Val Lys Val Asp  Thr Glu Val Gly His  Val Ile Arg 
    2090                 2095                 2100             


Tyr Val  Thr Ala Val Asp Arg  Asp Ser Gly Arg Asn  Gly Glu Val 
    2105                 2110                 2115             


His Tyr  Tyr Leu Lys Glu His  His Glu His Phe Gln  Ile Gly Pro 
    2120                 2125                 2130             


Leu Gly  Glu Ile Ser Leu Lys  Lys Gln Phe Glu Leu  Asp Thr Leu 
    2135                 2140                 2145             


Asn Lys  Glu Tyr Leu Val Thr  Val Val Ala Lys Asp  Gly Gly Asn 
    2150                 2155                 2160             


Pro Ala  Phe Ser Ala Glu Val  Ile Val Pro Ile Thr  Val Met Asn 
    2165                 2170                 2175             


Lys Ala  Met Pro Val Phe Glu  Lys Pro Phe Tyr Ser  Ala Glu Ile 
    2180                 2185                 2190             


Ala Glu  Ser Ile Gln Val His  Ser Pro Val Val His  Val Gln Ala 
    2195                 2200                 2205             


Asn Ser  Pro Glu Gly Leu Lys  Val Phe Tyr Ser Ile  Thr Asp Gly 
    2210                 2215                 2220             


Asp Pro  Phe Ser Gln Phe Thr  Ile Asn Phe Asn Thr  Gly Val Ile 
    2225                 2230                 2235             


Asn Val  Ile Ala Pro Leu Asp  Phe Glu Ala His Pro  Ala Tyr Lys 
    2240                 2245                 2250             


Leu Ser  Ile Arg Ala Thr Asp  Ser Leu Thr Gly Ala  His Ala Glu 
    2255                 2260                 2265             


Val Phe  Val Asp Ile Ile Val  Asp Asp Ile Asn Asp  Asn Pro Pro 
    2270                 2275                 2280             


Val Phe  Ala Gln Gln Ser Tyr  Ala Val Thr Leu Ser  Glu Ala Ser 
    2285                 2290                 2295             


Val Ile  Gly Thr Ser Val Val  Gln Val Arg Ala Thr  Asp Ser Asp 
    2300                 2305                 2310             


Ser Glu  Pro Asn Arg Gly Ile  Ser Tyr Gln Met Phe  Gly Asn His 
    2315                 2320                 2325             


Ser Lys  Ser His Asp His Phe  His Val Asp Ser Ser  Thr Gly Leu 
    2330                 2335                 2340             


Ile Ser  Leu Leu Arg Thr Leu  Asp Tyr Glu Gln Ser  Arg Gln His 
    2345                 2350                 2355             


Thr Ile  Phe Val Arg Ala Val  Asp Gly Gly Met Pro  Thr Leu Ser 
    2360                 2365                 2370             


Ser Asp  Val Ile Val Thr Val  Asp Val Thr Asp Leu  Asn Asp Asn 
    2375                 2380                 2385             


Pro Pro  Leu Phe Glu Gln Gln  Ile Tyr Glu Ala Arg  Ile Ser Glu 
    2390                 2395                 2400             


His Ala  Pro His Gly His Phe  Val Thr Cys Val Lys  Ala Tyr Asp 
    2405                 2410                 2415             


Ala Asp  Ser Ser Asp Ile Asp  Lys Leu Gln Tyr Ser  Ile Leu Ser 
    2420                 2425                 2430             


Gly Asn  Asp His Lys His Phe  Val Ile Asp Ser Ala  Thr Gly Ile 
    2435                 2440                 2445             


Ile Thr  Leu Ser Asn Leu His  Arg His Ala Leu Lys  Pro Phe Tyr 
    2450                 2455                 2460             


Ser Leu  Asn Leu Ser Val Ser  Asp Gly Val Phe Arg  Ser Ser Thr 
    2465                 2470                 2475             


Gln Val  His Val Thr Val Ile  Gly Gly Asn Leu His  Ser Pro Ala 
    2480                 2485                 2490             


Phe Leu  Gln Asn Glu Tyr Glu  Val Glu Leu Ala Glu  Asn Ala Pro 
    2495                 2500                 2505             


Leu His  Thr Leu Val Met Glu  Val Lys Thr Thr Asp  Gly Asp Ser 
    2510                 2515                 2520             


Gly Ile  Tyr Gly His Val Thr  Tyr His Ile Val Asn  Asp Phe Ala 
    2525                 2530                 2535             


Lys Asp  Arg Phe Tyr Ile Asn  Glu Arg Gly Gln Ile  Phe Thr Leu 
    2540                 2545                 2550             


Glu Lys  Leu Asp Arg Glu Thr  Pro Ala Glu Lys Val  Ile Ser Val 
    2555                 2560                 2565             


Arg Leu  Met Ala Lys Asp Ala  Gly Gly Lys Val Ala  Phe Cys Thr 
    2570                 2575                 2580             


Val Asn  Val Ile Leu Thr Asp  Asp Asn Asp Asn Ala  Pro Gln Phe 
    2585                 2590                 2595             


Arg Ala  Thr Lys Tyr Glu Val  Asn Ile Gly Ser Ser  Ala Ala Lys 
    2600                 2605                 2610             


Gly Thr  Ser Val Val Lys Val  Leu Ala Ser Asp Ala  Asp Glu Gly 
    2615                 2620                 2625             


Ser Asn  Ala Asp Ile Thr Tyr  Ala Ile Glu Ala Asp  Ser Glu Ser 
    2630                 2635                 2640             


Val Lys  Glu Asn Leu Glu Ile  Asn Lys Leu Ser Gly  Val Ile Thr 
    2645                 2650                 2655             


Thr Lys  Glu Ser Leu Ile Gly  Leu Glu Asn Glu Phe  Phe Thr Phe 
    2660                 2665                 2670             


Phe Val  Arg Ala Val Asp Asn  Gly Ser Pro Ser Lys  Glu Ser Val 
    2675                 2680                 2685             


Val Leu  Val Tyr Val Lys Ile  Leu Pro Pro Glu Met  Gln Leu Pro 
    2690                 2695                 2700             


Lys Phe  Ser Glu Pro Phe Tyr  Thr Phe Thr Val Ser  Glu Asp Val 
    2705                 2710                 2715             


Pro Ile  Gly Thr Glu Ile Asp  Leu Ile Arg Ala Glu  His Ser Gly 
    2720                 2725                 2730             


Thr Val  Leu Tyr Ser Leu Val  Lys Gly Asn Thr Pro  Glu Ser Asn 
    2735                 2740                 2745             


Arg Asp  Glu Ser Phe Val Ile  Asp Arg Gln Ser Gly  Arg Leu Lys 
    2750                 2755                 2760             


Leu Glu  Lys Ser Leu Asp His  Glu Thr Thr Lys Trp  Tyr Gln Phe 
    2765                 2770                 2775             


Ser Ile  Leu Ala Arg Cys Thr  Gln Asp Asp His Glu  Met Val Ala 
    2780                 2785                 2790             


Ser Val  Asp Val Ser Ile Gln  Val Lys Asp Ala Asn  Asp Asn Ser 
    2795                 2800                 2805             


Pro Val  Phe Glu Ser Ser Pro  Tyr Glu Ala Phe Ile  Val Glu Asn 
    2810                 2815                 2820             


Leu Pro  Gly Gly Ser Arg Val  Ile Gln Ile Arg Ala  Ser Asp Ala 
    2825                 2830                 2835             


Asp Ser  Gly Thr Asn Gly Gln  Val Met Tyr Ser Leu  Asp Gln Ser 
    2840                 2845                 2850             


Gln Ser  Val Glu Val Ile Glu  Ser Phe Ala Ile Asn  Met Glu Thr 
    2855                 2860                 2865             


Gly Trp  Ile Thr Thr Leu Lys  Glu Leu Asp His Glu  Lys Arg Asp 
    2870                 2875                 2880             


Asn Tyr  Gln Ile Lys Val Val  Ala Ser Asp His Gly  Glu Lys Ile 
    2885                 2890                 2895             


Gln Leu  Ser Ser Thr Ala Ile  Val Asp Val Thr Val  Thr Asp Val 
    2900                 2905                 2910             


Asn Asp  Ser Pro Pro Arg Phe  Thr Ala Glu Ile Tyr  Lys Gly Thr 
    2915                 2920                 2925             


Val Ser  Glu Asp Asp Pro Gln  Gly Gly Val Ile Ala  Ile Leu Ser 
    2930                 2935                 2940             


Thr Thr  Asp Ala Asp Ser Glu  Glu Ile Asn Arg Gln  Val Thr Tyr 
    2945                 2950                 2955             


Phe Ile  Thr Gly Gly Asp Pro  Leu Gly Gln Phe Ala  Val Glu Thr 
    2960                 2965                 2970             


Ile Gln  Asn Glu Trp Lys Val  Tyr Val Lys Lys Pro  Leu Asp Arg 
    2975                 2980                 2985             


Glu Lys  Arg Asp Asn Tyr Leu  Leu Thr Ile Thr Ala  Thr Asp Gly 
    2990                 2995                 3000             


Thr Phe  Ser Ser Lys Ala Ile  Val Glu Val Lys Val  Leu Asp Ala 
    3005                 3010                 3015             


Asn Asp  Asn Ser Pro Val Cys  Glu Lys Thr Leu Tyr  Ser Asp Thr 
    3020                 3025                 3030             


Ile Pro  Glu Asp Val Leu Pro  Gly Lys Leu Ile Met  Gln Ile Ser 
    3035                 3040                 3045             


Ala Thr  Asp Ala Asp Ile Arg  Ser Asn Ala Glu Ile  Thr Tyr Thr 
    3050                 3055                 3060             


Leu Leu  Gly Ser Gly Ala Glu  Lys Phe Lys Leu Asn  Pro Asp Thr 
    3065                 3070                 3075             


Gly Glu  Leu Lys Thr Ser Thr  Pro Leu Asp Arg Glu  Glu Gln Ala 
    3080                 3085                 3090             


Val Tyr  His Leu Leu Val Arg  Ala Thr Asp Gly Gly  Gly Arg Phe 
    3095                 3100                 3105             


Cys Gln  Ala Ser Ile Val Leu  Thr Leu Glu Asp Val  Asn Asp Asn 
    3110                 3115                 3120             


Ala Pro  Glu Phe Ser Ala Asp  Pro Tyr Ala Ile Thr  Val Phe Glu 
    3125                 3130                 3135             


Asn Thr  Glu Pro Gly Thr Leu  Leu Thr Arg Val Gln  Ala Thr Asp 
    3140                 3145                 3150             


Ala Asp  Ala Gly Leu Asn Arg  Lys Ile Leu Tyr Ser  Leu Ile Asp 
    3155                 3160                 3165             


Ser Ala  Asp Gly Gln Phe Ser  Ile Asn Glu Leu Ser  Gly Ile Ile 
    3170                 3175                 3180             


Gln Leu  Glu Lys Pro Leu Asp  Arg Glu Leu Gln Ala  Val Tyr Thr 
    3185                 3190                 3195             


Leu Ser  Leu Lys Ala Val Asp  Gln Gly Leu Pro Arg  Arg Leu Thr 
    3200                 3205                 3210             


Ala Thr  Gly Thr Val Ile Val  Ser Val Leu Asp Ile  Asn Asp Asn 
    3215                 3220                 3225             


Pro Pro  Val Phe Glu Tyr Arg  Glu Tyr Gly Ala Thr  Val Ser Glu 
    3230                 3235                 3240             


Asp Ile  Leu Val Gly Thr Glu  Val Leu Gln Val Tyr  Ala Ala Ser 
    3245                 3250                 3255             


Arg Asp  Ile Glu Ala Asn Ala  Glu Ile Thr Tyr Ser  Ile Ile Ser 
    3260                 3265                 3270             


Gly Asn  Glu His Gly Lys Phe  Ser Ile Asp Ser Lys  Thr Gly Ala 
    3275                 3280                 3285             


Val Phe  Ile Ile Glu Asn Leu  Asp Tyr Glu Ser Ser  His Glu Tyr 
    3290                 3295                 3300             


Tyr Leu  Thr Val Glu Ala Thr  Asp Gly Gly Thr Pro  Ser Leu Ser 
    3305                 3310                 3315             


Asp Val  Ala Thr Val Asn Val  Asn Val Thr Asp Ile  Asn Asp Asn 
    3320                 3325                 3330             


Thr Pro  Val Phe Ser Gln Asp  Thr Tyr Thr Thr Val  Ile Ser Glu 
    3335                 3340                 3345             


Asp Ala  Val Leu Glu Gln Ser  Val Ile Thr Val Met  Ala Asp Asp 
    3350                 3355                 3360             


Ala Asp  Gly Pro Ser Asn Ser  His Ile His Tyr Ser  Ile Ile Asp 
    3365                 3370                 3375             


Gly Asn  Gln Gly Ser Ser Phe  Thr Ile Asp Pro Val  Arg Gly Glu 
    3380                 3385                 3390             


Val Lys  Val Thr Lys Leu Leu  Asp Arg Glu Thr Ile  Ser Gly Tyr 
    3395                 3400                 3405             


Thr Leu  Thr Val Gln Ala Ser  Asp Asn Gly Ser Pro  Pro Arg Val 
    3410                 3415                 3420             


Asn Thr  Thr Thr Val Asn Ile  Asp Val Ser Asp Val  Asn Asp Asn 
    3425                 3430                 3435             


Ala Pro  Val Phe Ser Arg Gly  Asn Tyr Ser Val Ile  Ile Gln Glu 
    3440                 3445                 3450             


Asn Lys  Pro Val Gly Phe Ser  Val Leu Gln Leu Val  Val Thr Asp 
    3455                 3460                 3465             


Glu Asp  Ser Ser His Asn Gly  Pro Pro Phe Phe Phe  Thr Ile Val 
    3470                 3475                 3480             


Thr Gly  Asn Asp Glu Lys Ala  Phe Glu Val Asn Pro  Gln Gly Val 
    3485                 3490                 3495             


Leu Leu  Thr Ser Ser Ala Ile  Lys Arg Lys Glu Lys  Asp His Tyr 
    3500                 3505                 3510             


Leu Leu  Gln Val Lys Val Ala  Asp Asn Gly Lys Pro  Gln Leu Ser 
    3515                 3520                 3525             


Ser Leu  Thr Tyr Ile Asp Ile  Arg Val Ile Glu Glu  Ser Ile Tyr 
    3530                 3535                 3540             


Pro Pro  Ala Ile Leu Pro Leu  Glu Ile Phe Ile Thr  Ser Ser Gly 
    3545                 3550                 3555             


Glu Glu  Tyr Ser Gly Gly Val  Ile Gly Lys Ile His  Ala Thr Asp 
    3560                 3565                 3570             


Gln Asp  Val Tyr Asp Thr Leu  Thr Tyr Ser Leu Asp  Pro Gln Met 
    3575                 3580                 3585             


Asp Asn  Leu Phe Ser Val Ser  Ser Thr Gly Gly Lys  Leu Ile Ala 
    3590                 3595                 3600             


His Lys  Lys Leu Asp Ile Gly  Gln Tyr Leu Leu Asn  Val Ser Val 
    3605                 3610                 3615             


Thr Asp  Gly Lys Phe Thr Thr  Val Ala Asp Ile Thr  Val His Ile 
    3620                 3625                 3630             


Arg Gln  Val Thr Gln Glu Met  Leu Asn His Thr Ile  Ala Ile Arg 
    3635                 3640                 3645             


Phe Ala  Asn Leu Thr Pro Glu  Glu Phe Val Gly Asp  Tyr Trp Arg 
    3650                 3655                 3660             


Asn Phe  Gln Arg Ala Leu Arg  Asn Ile Leu Gly Val  Arg Arg Asn 
    3665                 3670                 3675             


Asp Ile  Gln Ile Val Ser Leu  Gln Ser Ser Glu Pro  His Pro His 
    3680                 3685                 3690             


Leu Asp  Val Leu Leu Phe Val  Glu Lys Pro Gly Ser  Ala Gln Ile 
    3695                 3700                 3705             


Ser Thr  Lys Gln Leu Leu His  Lys Ile Asn Ser Ser  Val Thr Asp 
    3710                 3715                 3720             


Ile Glu  Glu Ile Ile Gly Val  Arg Ile Leu Asn Val  Phe Gln Lys 
    3725                 3730                 3735             


Leu Cys  Ala Gly Leu Asp Cys  Pro Trp Lys Phe Cys  Asp Glu Lys 
    3740                 3745                 3750             


Val Ser  Val Asp Glu Ser Val  Met Ser Thr His Ser  Thr Ala Arg 
    3755                 3760                 3765             


Leu Ser  Phe Val Thr Pro Arg  His His Arg Ala Ala  Val Cys Leu 
    3770                 3775                 3780             


Cys Lys  Glu Gly Arg Cys Pro  Pro Val His His Gly  Cys Glu Asp 
    3785                 3790                 3795             


Asp Pro  Cys Pro Glu Gly Ser  Glu Cys Val Ser Asp  Pro Trp Glu 
    3800                 3805                 3810             


Glu Lys  His Thr Cys Val Cys  Pro Ser Gly Arg Phe  Gly Gln Cys 
    3815                 3820                 3825             


Pro Gly  Ser Ser Ser Met Thr  Leu Thr Gly Asn Ser  Tyr Val Lys 
    3830                 3835                 3840             


Tyr Arg  Leu Thr Glu Asn Glu  Asn Lys Leu Glu Met  Lys Leu Thr 
    3845                 3850                 3855             


Met Arg  Leu Arg Thr Tyr Ser  Thr His Ala Val Val  Met Tyr Ala 
    3860                 3865                 3870             


Arg Gly  Thr Asp Tyr Ser Ile  Leu Glu Ile His His  Gly Arg Leu 
    3875                 3880                 3885             


Gln Tyr  Lys Phe Asp Cys Gly  Ser Gly Pro Gly Ile  Val Ser Val 
    3890                 3895                 3900             


Gln Ser  Ile Gln Val Asn Asp  Gly Gln Trp His Ala  Val Ala Leu 
    3905                 3910                 3915             


Glu Val  Asn Gly Asn Tyr Ala  Arg Leu Val Leu Asp  Gln Val His 
    3920                 3925                 3930             


Thr Ala  Ser Gly Thr Ala Pro  Gly Thr Leu Lys Thr  Leu Asn Leu 
    3935                 3940                 3945             


Asp Asn  Tyr Val Phe Phe Gly  Gly His Ile Arg Gln  Gln Gly Thr 
    3950                 3955                 3960             


Arg His  Gly Arg Ser Pro Gln  Val Gly Asn Gly Phe  Arg Gly Cys 
    3965                 3970                 3975             


Met Asp  Ser Ile Tyr Leu Asn  Gly Gln Glu Leu Pro  Leu Asn Ser 
    3980                 3985                 3990             


Lys Pro  Arg Ser Tyr Ala His  Ile Glu Glu Ser Val  Asp Val Ser 
    3995                 4000                 4005             


Pro Gly  Cys Phe Leu Thr Ala  Thr Glu Asp Cys Ala  Ser Asn Pro 
    4010                 4015                 4020             


Cys Gln  Asn Gly Gly Val Cys  Asn Pro Ser Pro Ala  Gly Gly Tyr 
    4025                 4030                 4035             


Tyr Cys  Lys Cys Ser Ala Leu  Tyr Ile Gly Thr His  Cys Glu Ile 
    4040                 4045                 4050             


Ser Val  Asn Pro Cys Ser Ser  Lys Pro Cys Leu Tyr  Gly Gly Thr 
    4055                 4060                 4065             


Cys Val  Val Asp Asn Gly Gly  Phe Val Cys Gln Cys  Arg Gly Leu 
    4070                 4075                 4080             


Tyr Thr  Gly Gln Arg Cys Gln  Leu Ser Pro Tyr Cys  Lys Asp Glu 
    4085                 4090                 4095             


Pro Cys  Lys Asn Gly Gly Thr  Cys Phe Asp Ser Leu  Asp Gly Ala 
    4100                 4105                 4110             


Val Cys  Gln Cys Asp Ser Gly  Phe Arg Gly Glu Arg  Cys Gln Ser 
    4115                 4120                 4125             


Asp Ile  Asp Glu Cys Ser Gly  Asn Pro Cys Leu His  Gly Ala Leu 
    4130                 4135                 4140             


Cys Glu  Asn Thr His Gly Ser  Tyr His Cys Asn Cys  Ser His Glu 
    4145                 4150                 4155             


Tyr Arg  Gly Arg His Cys Glu  Asp Ala Ala Pro Asn  Gln Tyr Val 
    4160                 4165                 4170             


Ser Thr  Pro Trp Asn Ile Gly  Leu Ala Glu Gly Ile  Gly Ile Val 
    4175                 4180                 4185             


Val Phe  Val Ala Gly Ile Phe  Leu Leu Val Val Val  Phe Val Leu 
    4190                 4195                 4200             


Cys Arg  Lys Met Ile Ser Arg  Lys Lys Lys His Gln  Ala Glu Pro 
    4205                 4210                 4215             


Lys Asp  Lys His Leu Gly Pro  Ala Thr Ala Phe Leu  Gln Arg Pro 
    4220                 4225                 4230             


Tyr Phe  Asp Ser Lys Leu Asn  Lys Asn Ile Tyr Ser  Asp Ile Pro 
    4235                 4240                 4245             


Pro Gln  Val Pro Val Arg Pro  Ile Ser Tyr Thr Pro  Ser Ile Pro 
    4250                 4255                 4260             


Ser Asp  Ser Arg Asn Asn Leu  Asp Arg Asn Ser Phe  Glu Gly Ser 
    4265                 4270                 4275             


Ala Ile  Pro Glu His Pro Glu  Phe Ser Thr Phe Asn  Pro Glu Ser 
    4280                 4285                 4290             


Val His  Gly His Arg Lys Ala  Val Ala Val Cys Ser  Val Ala Pro 
    4295                 4300                 4305             


Asn Leu  Pro Pro Pro Pro Pro  Ser Asn Ser Pro Ser  Asp Ser Asp 
    4310                 4315                 4320             


Ser Ile  Gln Lys Pro Ser Trp  Asp Phe Asp Tyr Asp  Thr Lys Val 
    4325                 4330                 4335             


Val Asp  Leu Asp Pro Cys Leu  Ser Lys Lys Pro Leu  Glu Glu Lys 
    4340                 4345                 4350             


Pro Ser  Gln Pro Tyr Ser Ala  Arg Glu Ser Leu Ser  Glu Val Gln 
    4355                 4360                 4365             


Ser Leu  Ser Ser Phe Gln Ser  Glu Ser Cys Asp Asp  Asn Gly Tyr 
    4370                 4375                 4380             


His Trp  Asp Thr Ser Asp Trp  Met Pro Ser Val Pro  Leu Pro Asp 
    4385                 4390                 4395             


Ile Gln  Glu Phe Pro Asn Tyr  Glu Val Ile Asp Glu  Gln Thr Pro 
    4400                 4405                 4410             


Leu Tyr  Ser Ala Asp Pro Asn  Ala Ile Asp Thr Asp  Tyr Tyr Pro 
    4415                 4420                 4425             


Gly Gly  Tyr Asp Ile Glu Ser  Asp Phe Pro Pro Pro  Pro Glu Asp 
    4430                 4435                 4440             


Phe Pro  Ala Ala Asp Glu Leu  Pro Pro Leu Pro Pro  Glu Phe Ser 
    4445                 4450                 4455             


Asn Gln  Phe Glu Ser Ile His  Pro Pro Arg Asp Met  Pro Ala Ala 
    4460                 4465                 4470             


Gly Ser  Leu Gly Ser Ser Ser  Arg Asn Arg Gln Arg  Phe Asn Leu 
    4475                 4480                 4485             


Asn Gln  Tyr Leu Pro Asn Phe  Tyr Pro Leu Asp Met  Ser Glu Pro 
    4490                 4495                 4500             


Gln Thr  Lys Gly Thr Gly Glu  Asn Ser Thr Cys Arg  Glu Pro His 
    4505                 4510                 4515             


Ala Pro  Tyr Pro Pro Gly Tyr  Gln Arg His Phe Glu  Ala Pro Ala 
    4520                 4525                 4530             


Val Glu  Ser Met Pro Met Ser  Val Tyr Ala Ser Thr  Ala Ser Cys 
    4535                 4540                 4545             


Ser Asp  Val Ser Ala Cys Cys  Glu Val Glu Ser Glu  Val Met Met 
    4550                 4555                 4560             


Ser Asp  Tyr Glu Ser Gly Asp  Asp Gly His Phe Glu  Glu Val Thr 
    4565                 4570                 4575             


Ile Pro  Pro Leu Asp Ser Gln  Gln His Thr Glu Val  
    4580                 4585                 4590 


<210>  5118
<211>  52
<212>  PRT
<213>  Homo Sapiens

<400>  5118

Met Thr Met Ala Val Ile Val Arg Asn Lys Glu Lys Lys Val Ile Phe 
1               5                   10                  15      


Glu Phe Ser Gly Gln Ile Ser Gly Ser Ser Phe Arg Ser His Phe Pro 
            20                  25                  30          


Pro Leu Pro Tyr Ser Ile Leu Phe Val Val His Thr Phe Leu Ser His 
        35                  40                  45              


Leu Glu Leu Ser 
    50          


<210>  5119
<211>  368
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5119

Xaa Asp Ser Lys Leu Asn Lys Asn Ile Tyr Ser Asp Ile Pro Pro Gln 
1               5                   10                  15      


Val Pro Val Arg Pro Ile Ser Tyr Thr Pro Ser Ile Pro Ser Asp Ser 
            20                  25                  30          


Arg Asn Asn Leu Asp Arg Asn Ser Phe Glu Gly Ser Ala Ile Pro Glu 
        35                  40                  45              


His Pro Glu Phe Ser Thr Phe Asn Pro Glu Ser Val His Gly His Arg 
    50                  55                  60                  


Lys Ala Val Ala Val Cys Ser Val Ala Pro Asn Leu Pro Pro Pro Pro 
65                  70                  75                  80  


Pro Ser Asn Ser Pro Ser Asp Ser Asp Ser Ile Gln Lys Pro Ser Trp 
                85                  90                  95      


Asp Phe Asp Tyr Asp Thr Lys Val Val Asp Leu Asp Pro Cys Leu Ser 
            100                 105                 110         


Lys Lys Pro Leu Glu Glu Lys Pro Ser Gln Pro Tyr Ser Ala Arg Glu 
        115                 120                 125             


Ser Leu Ser Glu Val Gln Ser Leu Ser Ser Phe Gln Ser Glu Ser Cys 
    130                 135                 140                 


Asp Asp Asn Glu Ser Leu Ala Ala Pro Asp Leu Ser Lys Pro Arg Gly 
145                 150                 155                 160 


Tyr His Trp Asp Thr Ser Asp Trp Met Pro Ser Val Pro Leu Pro Asp 
                165                 170                 175     


Ile Gln Glu Phe Pro Asn Tyr Glu Val Ile Asp Glu Gln Thr Pro Leu 
            180                 185                 190         


Tyr Ser Ala Asp Pro Asn Ala Ile Asp Thr Asp Tyr Tyr Pro Gly Gly 
        195                 200                 205             


Tyr Asp Ile Glu Ser Asp Phe Pro Pro Pro Pro Glu Asp Phe Pro Ala 
    210                 215                 220                 


Ala Asp Glu Leu Pro Pro Leu Pro Pro Glu Phe Ser Asn Gln Phe Glu 
225                 230                 235                 240 


Ser Ile His Pro Pro Arg Asp Met Pro Ala Ala Gly Ser Leu Gly Ser 
                245                 250                 255     


Ser Ser Arg Asn Arg Gln Arg Phe Asn Leu Asn Gln Tyr Leu Pro Asn 
            260                 265                 270         


Phe Tyr Pro Leu Asp Met Ser Glu Pro Gln Thr Lys Gly Thr Gly Glu 
        275                 280                 285             


Asn Ser Thr Cys Arg Glu Pro His Ala Pro Tyr Pro Pro Gly Tyr Gln 
    290                 295                 300                 


Arg His Phe Glu Ala Pro Ala Val Glu Ser Met Pro Met Ser Val Tyr 
305                 310                 315                 320 


Ala Ser Thr Ala Ser Cys Ser Asp Val Ser Ala Cys Cys Glu Val Glu 
                325                 330                 335     


Ser Glu Val Met Met Ser Asp Tyr Glu Ser Gly Asp Asp Gly His Phe 
            340                 345                 350         


Glu Glu Val Thr Ile Pro Pro Leu Asp Ser Gln Gln His Thr Glu Val 
        355                 360                 365             


<210>  5120
<211>  285
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5120

Xaa Ser Thr Thr Glu Ala Leu Phe Ala Ser Val Glu Asp Tyr Ile Leu 
1               5                   10                  15      


Val Arg Gly Val Ser Leu Val His Thr Ala Lys Met Asn Pro Val Arg 
            20                  25                  30          


Met Ala Glu His Ala Leu Thr Val Trp Met Ala Pro Phe Val Ser Val 
        35                  40                  45              


Ile Arg Val Leu Gly Glu Lys Gly Val Arg Val Ile Ser Thr Ser Ala 
    50                  55                  60                  


Leu Glu Thr Leu Ala Cys Thr Gly Pro Ser Val Arg Thr Arg Thr Ala 
65                  70                  75                  80  


Pro Ile Thr Ala Thr Ala Ala Thr Ser Thr Gly Asp Val Thr Ala Arg 
                85                  90                  95      


Met Leu Arg Pro Thr Thr Lys Val Val Asp Leu Asp Pro Cys Leu Ser 
            100                 105                 110         


Lys Lys Pro Leu Glu Glu Lys Pro Ser Gln Pro Tyr Ser Ala Arg Glu 
        115                 120                 125             


Ser Leu Ser Glu Val Gln Ser Leu Ser Ser Phe Gln Ser Glu Ser Cys 
    130                 135                 140                 


Asp Asp Asn Gly Tyr His Trp Asp Thr Ser Asp Trp Met Pro Ser Val 
145                 150                 155                 160 


Pro Leu Pro Asp Ile Gln Glu Phe Pro Asn Tyr Glu Val Ile Asp Glu 
                165                 170                 175     


Gln Thr Pro Leu Tyr Ser Ala Asp Pro Asn Ala Ile Asp Thr Asp Tyr 
            180                 185                 190         


Tyr Pro Gly Gly Tyr Asp Ile Glu Ser Asp Phe Pro Pro Pro Pro Glu 
        195                 200                 205             


Asp Phe Pro Ala Ala Asp Glu Leu Pro Pro Leu Pro Pro Glu Phe Ser 
    210                 215                 220                 


Asn Gln Phe Glu Ser Ile His Pro Pro Arg Asp Met Pro Ala Ala Gly 
225                 230                 235                 240 


Ser Leu Gly Ser Ser Ser Arg Asn Arg Gln Arg Phe Asn Leu Asn Gln 
                245                 250                 255     


Tyr Leu Pro Asn Phe Tyr Pro Leu Asp Met Ser Glu Pro Gln Thr Lys 
            260                 265                 270         


Gly Thr Gly Glu Asn Ser Thr Cys Arg Glu Pro His Ala 
        275                 280                 285 


<210>  5121
<211>  92
<212>  PRT
<213>  Homo Sapiens

<400>  5121

Ala Leu Leu Ala Ala Gly Gly Arg Gly Val Pro Gly Pro Pro Pro Gln 
1               5                   10                  15      


Leu Arg Val Pro Thr Pro Ser Ala Ser Arg Ser Leu Arg Val Ser Glu 
            20                  25                  30          


Pro Arg Gly Leu Gly Val Arg Ala Leu Pro Cys Ala Ala Pro Pro Asp 
        35                  40                  45              


Cys Gln Arg Arg Gly Leu Gly Asp Ala Pro Leu Pro His Gly Gln Leu 
    50                  55                  60                  


Arg Ser Ser Ser Pro Pro Arg Pro Gly Asp Leu Phe Gln Asn Arg Ile 
65                  70                  75                  80  


Pro Pro Pro Leu Lys His Thr Val Leu Pro Gln Ser 
                85                  90          


<210>  5122
<211>  181
<212>  PRT
<213>  Homo Sapiens

<400>  5122

Cys Arg Met Val Gln Glu Gln Cys Cys His Ser Gln Leu Glu Glu Leu 
1               5                   10                  15      


His Cys Ala Thr Gly Ile Ser Leu Ala Asn Glu Gln Asp Arg Cys Ala 
            20                  25                  30          


Thr Pro His Gly Asp Asn Ala Ser Leu Glu Ala Thr Phe Val Lys Arg 
        35                  40                  45              


Cys Cys His Cys Cys Leu Leu Gly Arg Ala Ala Gln Ala Gln Gly Gln 
    50                  55                  60                  


Ser Cys Glu Tyr Ser Leu Met Val Gly Tyr Gln Cys Gly Gln Val Phe 
65                  70                  75                  80  


Gln Ala Cys Cys Val Lys Ser Gln Glu Thr Gly Asp Leu Asp Val Gly 
                85                  90                  95      


Gly Leu Gln Glu Thr Gly Gly Gly Pro Cys Lys Gln Gln Cys Arg Asp 
            100                 105                 110         


Thr Gly Asp Glu Val Val Cys Ser Cys Phe Val Gly Tyr Gln Leu Leu 
        115                 120                 125             


Ser Asp Gly Val Ser Cys Glu Asp Val Asn Glu Cys Ile Thr Gly Ser 
    130                 135                 140                 


His Ser Cys Arg Leu Gly Glu Ser Cys Ile Asn Thr Val Gly Ser Phe 
145                 150                 155                 160 


Arg Cys Gln Arg Asp Ser Ser Cys Gly Thr Gly Tyr Glu Leu Thr Glu 
                165                 170                 175     


Asp Asn Ser Cys Lys 
            180     


<210>  5123
<211>  60
<212>  PRT
<213>  Homo Sapiens

<400>  5123

Asp Ile Thr Glu Gly Asn Leu Arg Asp Ser Phe Asp Ile Ile Lys Arg 
1               5                   10                  15      


Tyr Met Asp Gly Met Thr Val Ala Pro Leu Leu Asn Cys His Ile Leu 
            20                  25                  30          


Lys Asp Leu Gln Ser Trp Glu Met Lys Thr Val Ala Ser Ala Ile Leu 
        35                  40                  45              


Asp Ser Asp Leu Tyr Ser Glu His Phe Gln Ser Ser 
    50                  55                  60  


<210>  5124
<211>  65
<212>  PRT
<213>  Homo Sapiens

<400>  5124

Met Ala Thr His Gln Lys Asp Cys Ser Leu Pro Tyr Ala Thr Glu Ser 
1               5                   10                  15      


Lys Glu Cys Arg Met Val Gln Glu Gln Cys Cys His Ser Gln Leu Glu 
            20                  25                  30          


Glu Leu His Cys Ala Thr Gly Ile Ser Leu Ala Asn Glu Gln Asp Arg 
        35                  40                  45              


Cys Ala Thr Pro His Gly Asp Asn Ala Ser Leu Glu Ala Thr Phe Val 
    50                  55                  60                  


Lys 
65  


<210>  5125
<211>  139
<212>  PRT
<213>  Homo Sapiens

<400>  5125

Met Ala Thr His Gln Lys Asp Cys Ser Leu Pro Tyr Ala Thr Glu Ser 
1               5                   10                  15      


Lys Glu Cys Arg Met Val Gln Glu Gln Cys Cys His Ser Gln Leu Glu 
            20                  25                  30          


Glu Leu His Cys Ala Thr Gly Ile Ser Leu Ala Asn Glu Gln Asp Arg 
        35                  40                  45              


Cys Ala Thr Pro His Gly Asp Asn Ala Ser Leu Glu Ala Thr Phe Val 
    50                  55                  60                  


Lys Arg Cys Cys His Cys Cys Leu Leu Gly Arg Ala Ala Gln Ala Gln 
65                  70                  75                  80  


Gly Gln Ser Cys Glu Tyr Ser Leu Met Val Gly Tyr Gln Cys Gly Gln 
                85                  90                  95      


Val Phe Gln Ala Cys Cys Val Lys Ser Gln Glu Thr Gly Asp Leu Asp 
            100                 105                 110         


Val Gly Gly Leu Gln Glu Thr Asp Lys Ile Ile Glu Val Glu Glu Glu 
        115                 120                 125             


Gln Glu Asp Pro Tyr Leu Asn Asp Arg Cys Arg 
    130                 135                 


<210>  5126
<211>  721
<212>  PRT
<213>  Homo Sapiens

<400>  5126

Met Glu Arg Ala Ala Pro Ser Arg Arg Val Pro Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Gly Gly Leu Ala Leu Leu Ala Ala Gly Val Asp Ala Asp Val Leu 
            20                  25                  30          


Leu Glu Ala Cys Cys Ala Asp Gly His Arg Met Ala Thr His Gln Lys 
        35                  40                  45              


Asp Cys Ser Leu Pro Tyr Ala Thr Glu Ser Lys Glu Cys Arg Ala Val 
    50                  55                  60                  


Gly Leu Ala Ser Leu Cys Gln Asp Leu Asn Gly Ala Trp Ala Val Trp 
65                  70                  75                  80  


Lys Val Gly Arg Ala Ser Gln Ala Glu Gly Thr Ala Ser Ala Arg Ala 
                85                  90                  95      


Gln Arg Arg Gly Met Val Gln Glu Gln Cys Cys His Ser Gln Leu Glu 
            100                 105                 110         


Glu Leu His Cys Ala Thr Gly Ile Ser Leu Ala Asn Glu Gln Asp Arg 
        115                 120                 125             


Cys Ala Thr Pro His Gly Asp Asn Ala Ser Leu Glu Ala Thr Phe Val 
    130                 135                 140                 


Lys Arg Cys Cys His Cys Cys Leu Leu Gly Arg Ala Ala Gln Ala Gln 
145                 150                 155                 160 


Gly Gln Ser Cys Glu Tyr Ser Leu Met Val Gly Tyr Gln Cys Gly Gln 
                165                 170                 175     


Val Phe Gln Ala Cys Cys Val Lys Ser Gln Glu Thr Gly Asp Leu Asp 
            180                 185                 190         


Val Gly Gly Leu Gln Glu Thr Asp Lys Ile Ile Glu Val Glu Glu Glu 
        195                 200                 205             


Gln Glu Asp Pro Tyr Leu Asn Asp Arg Cys Arg Gly Gly Gly Pro Cys 
    210                 215                 220                 


Lys Gln Gln Cys Arg Asp Thr Gly Asp Glu Val Val Cys Ser Cys Phe 
225                 230                 235                 240 


Val Gly Tyr Gln Leu Leu Ser Asp Gly Val Ser Cys Glu Asp Val Asn 
                245                 250                 255     


Glu Cys Ile Thr Gly Ser His Ser Cys Arg Leu Gly Glu Ser Cys Ile 
            260                 265                 270         


Asn Thr Val Gly Ser Phe Arg Cys Gln Arg Asp Ser Ser Cys Gly Thr 
        275                 280                 285             


Gly Tyr Glu Leu Thr Glu Asp Asn Ser Cys Lys Asp Ile Asp Glu Cys 
    290                 295                 300                 


Glu Ser Gly Ile His Asn Cys Leu Pro Asp Phe Ile Cys Gln Asn Thr 
305                 310                 315                 320 


Leu Gly Ser Phe Arg Cys Arg Pro Lys Leu Gln Cys Lys Ser Gly Phe 
                325                 330                 335     


Ile Gln Asp Ala Leu Gly Asn Cys Ile Asp Ile Asn Glu Cys Leu Ser 
            340                 345                 350         


Ile Ser Ala Pro Cys Pro Ile Gly His Thr Cys Ile Asn Thr Glu Gly 
        355                 360                 365             


Ser Tyr Thr Cys Gln Lys Asn Val Pro Asn Cys Gly Arg Gly Tyr His 
    370                 375                 380                 


Leu Asn Glu Glu Gly Thr Arg Cys Val Asp Val Asp Glu Cys Ala Pro 
385                 390                 395                 400 


Pro Ala Glu Pro Cys Gly Lys Gly His Arg Cys Val Asn Ser Pro Gly 
                405                 410                 415     


Ser Phe Arg Cys Glu Cys Lys Thr Gly Tyr Tyr Phe Asp Gly Ile Ser 
            420                 425                 430         


Arg Met Cys Val Asp Val Asn Glu Cys Gln Arg Tyr Pro Gly Arg Leu 
        435                 440                 445             


Cys Gly His Lys Cys Glu Asn Thr Leu Gly Ser Tyr Leu Cys Ser Cys 
    450                 455                 460                 


Ser Val Gly Phe Arg Leu Ser Val Asp Gly Arg Ser Cys Glu Asp Ile 
465                 470                 475                 480 


Asn Glu Cys Ser Ser Ser Pro Cys Ser Gln Glu Cys Ala Asn Val Tyr 
                485                 490                 495     


Gly Ser Tyr Gln Cys Tyr Cys Arg Arg Gly Tyr Gln Leu Ser Asp Val 
            500                 505                 510         


Asp Gly Val Thr Cys Glu Asp Ile Asp Glu Cys Ala Leu Pro Thr Gly 
        515                 520                 525             


Gly His Ile Cys Ser Tyr Arg Cys Ile Asn Ile Pro Gly Ser Phe Gln 
    530                 535                 540                 


Cys Ser Cys Pro Ser Ser Gly Tyr Arg Leu Ala Pro Asn Gly Arg Asn 
545                 550                 555                 560 


Cys Gln Asp Ile Asp Glu Cys Val Thr Gly Ile His Asn Cys Ser Ile 
                565                 570                 575     


Asn Glu Thr Cys Phe Asn Ile Gln Gly Gly Phe Arg Cys Leu Ala Phe 
            580                 585                 590         


Glu Cys Pro Glu Asn Tyr Arg Arg Ser Ala Ala Thr Arg Cys Glu Arg 
        595                 600                 605             


Leu Pro Cys His Glu Asn Arg Glu Cys Ser Lys Leu Pro Leu Arg Ile 
    610                 615                 620                 


Thr Tyr Tyr His Leu Ser Phe Pro Thr Asn Ile Gln Ala Pro Ala Val 
625                 630                 635                 640 


Val Phe Arg Met Gly Pro Ser Ser Ala Val Pro Gly Asp Ser Met Gln 
                645                 650                 655     


Leu Ala Ile Thr Gly Gly Asn Glu Glu Gly Phe Phe Thr Thr Arg Lys 
            660                 665                 670         


Val Ser Pro His Ser Gly Val Val Ala Leu Thr Lys Pro Val Pro Glu 
        675                 680                 685             


Pro Arg Asp Leu Leu Leu Thr Val Lys Met Asp Leu Ser Arg His Gly 
    690                 695                 700                 


Thr Val Ser Ser Phe Val Ala Lys Leu Phe Ile Phe Val Ser Ala Glu 
705                 710                 715                 720 


Leu 
    


<210>  5127
<211>  683
<212>  PRT
<213>  Homo Sapiens

<400>  5127

Met Glu Arg Ala Ala Pro Ser Arg Arg Val Pro Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Gly Gly Leu Ala Leu Leu Ala Ala Gly Val Asp Ala Asp Val Leu 
            20                  25                  30          


Leu Glu Ala Cys Cys Ala Asp Gly His Arg Met Ala Thr His Gln Lys 
        35                  40                  45              


Asp Cys Ser Leu Pro Tyr Ala Thr Glu Ser Lys Glu Cys Arg Met Val 
    50                  55                  60                  


Gln Glu Gln Cys Cys His Ser Gln Leu Glu Glu Leu His Cys Ala Thr 
65                  70                  75                  80  


Gly Ile Ser Leu Ala Asn Glu Gln Asp Arg Cys Ala Thr Pro His Gly 
                85                  90                  95      


Asp Asn Ala Ser Leu Glu Ala Thr Phe Val Lys Arg Cys Cys His Cys 
            100                 105                 110         


Cys Leu Leu Gly Arg Ala Ala Gln Ala Gln Gly Gln Ser Cys Glu Tyr 
        115                 120                 125             


Ser Leu Met Val Gly Tyr Gln Cys Gly Gln Val Phe Gln Ala Cys Cys 
    130                 135                 140                 


Val Lys Ser Gln Glu Thr Gly Asp Leu Asp Val Gly Gly Leu Gln Glu 
145                 150                 155                 160 


Thr Asp Lys Ile Ile Glu Val Glu Glu Glu Gln Glu Asp Pro Tyr Leu 
                165                 170                 175     


Asn Asp Arg Cys Arg Gly Gly Gly Pro Cys Lys Gln Gln Cys Arg Asp 
            180                 185                 190         


Thr Gly Asp Glu Val Val Cys Ser Cys Phe Val Gly Tyr Gln Leu Leu 
        195                 200                 205             


Ser Asp Gly Val Ser Cys Glu Asp Val Asn Glu Cys Ile Thr Gly Ser 
    210                 215                 220                 


His Ser Cys Arg Leu Gly Glu Ser Cys Ile Asn Thr Val Gly Ser Phe 
225                 230                 235                 240 


Arg Cys Gln Arg Asp Ser Ser Cys Gly Thr Gly Tyr Glu Leu Thr Glu 
                245                 250                 255     


Asp Asn Ser Cys Lys Asp Ile Asp Glu Cys Glu Ser Gly Ile His Asn 
            260                 265                 270         


Cys Leu Pro Asp Phe Ile Cys Gln Asn Thr Leu Gly Ser Phe Arg Cys 
        275                 280                 285             


Arg Pro Lys Leu Gln Cys Lys Ser Gly Phe Ile Gln Asp Ala Leu Gly 
    290                 295                 300                 


Asn Cys Ile Asp Ile Asn Glu Cys Leu Ser Ile Ser Ala Pro Cys Pro 
305                 310                 315                 320 


Ile Gly His Thr Cys Ile Asn Thr Glu Gly Ser Tyr Thr Cys Gln Lys 
                325                 330                 335     


Asn Val Pro Asn Cys Gly Arg Gly Tyr His Leu Asn Glu Glu Gly Thr 
            340                 345                 350         


Arg Cys Val Asp Val Asp Glu Cys Ala Pro Pro Ala Glu Pro Cys Gly 
        355                 360                 365             


Lys Gly His Arg Cys Val Asn Ser Pro Gly Ser Phe Arg Cys Glu Cys 
    370                 375                 380                 


Lys Thr Gly Tyr Tyr Phe Asp Gly Ile Ser Arg Met Cys Val Asp Val 
385                 390                 395                 400 


Asn Glu Cys Gln Arg Tyr Pro Gly Arg Leu Cys Gly His Lys Cys Glu 
                405                 410                 415     


Asn Thr Leu Gly Ser Tyr Leu Cys Ser Cys Ser Val Gly Phe Arg Leu 
            420                 425                 430         


Ser Val Asp Gly Arg Ser Cys Glu Asp Ile Asn Glu Cys Ser Ser Ser 
        435                 440                 445             


Pro Cys Ser Gln Glu Cys Ala Asn Val Tyr Gly Ser Tyr Gln Cys Tyr 
    450                 455                 460                 


Cys Arg Arg Gly Tyr Gln Leu Ser Asp Val Asp Gly Val Thr Cys Glu 
465                 470                 475                 480 


Asp Ile Asp Glu Cys Ala Leu Pro Thr Gly Gly His Ile Cys Ser Tyr 
                485                 490                 495     


Arg Cys Ile Asn Ile Pro Gly Ser Phe Gln Cys Ser Cys Pro Ser Ser 
            500                 505                 510         


Gly Tyr Arg Leu Ala Pro Asn Gly Arg Asn Cys Gln Asp Ile Asp Glu 
        515                 520                 525             


Cys Val Thr Gly Ile His Asn Cys Ser Ile Asn Glu Thr Cys Phe Asn 
    530                 535                 540                 


Ile Gln Gly Gly Phe Arg Cys Leu Ala Phe Glu Cys Pro Glu Asn Tyr 
545                 550                 555                 560 


Arg Arg Ser Ala Ala Thr Arg Cys Glu Arg Leu Pro Cys His Glu Asn 
                565                 570                 575     


Arg Glu Cys Ser Lys Leu Pro Leu Arg Ile Thr Tyr Tyr His Leu Ser 
            580                 585                 590         


Phe Pro Thr Asn Ile Gln Ala Pro Ala Val Val Phe Arg Met Gly Pro 
        595                 600                 605             


Ser Ser Ala Val Pro Gly Asp Ser Met Gln Leu Ala Ile Thr Gly Gly 
    610                 615                 620                 


Asn Glu Glu Gly Phe Phe Thr Thr Arg Lys Val Ser Pro His Ser Gly 
625                 630                 635                 640 


Val Val Ala Leu Thr Lys Pro Val Pro Glu Pro Arg Asp Leu Leu Leu 
                645                 650                 655     


Thr Val Lys Met Asp Leu Ser Arg His Gly Thr Val Ser Ser Phe Val 
            660                 665                 670         


Ala Lys Leu Phe Ile Phe Val Ser Ala Glu Leu 
        675                 680             


<210>  5128
<211>  703
<212>  PRT
<213>  Homo Sapiens

<400>  5128

Met Glu Arg Ala Ala Pro Ser Arg Arg Val Pro Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Gly Gly Leu Ala Leu Leu Ala Ala Gly Val Asp Ala Asp Val Leu 
            20                  25                  30          


Leu Glu Ala Cys Cys Ala Asp Gly His Arg Met Ala Thr His Gln Lys 
        35                  40                  45              


Asp Cys Ser Leu Pro Tyr Ala Thr Glu Ser Lys Glu Cys Arg Met Val 
    50                  55                  60                  


Gln Glu Gln Cys Cys His Ser Gln Leu Glu Glu Leu His Cys Ala Thr 
65                  70                  75                  80  


Gly Ile Ser Leu Ala Asn Glu Gln Asp Arg Cys Ala Thr Pro His Gly 
                85                  90                  95      


Asp Asn Ala Ser Leu Glu Ala Thr Phe Val Lys Arg Cys Cys His Cys 
            100                 105                 110         


Cys Leu Leu Gly Arg Ala Ala Gln Ala Gln Gly Gln Ser Cys Glu Tyr 
        115                 120                 125             


Ser Leu Met Val Gly Tyr Gln Cys Gly Gln Val Phe Gln Ala Cys Cys 
    130                 135                 140                 


Val Lys Ser Gln Glu Thr Gly Asp Leu Asp Val Gly Gly Leu Gln Glu 
145                 150                 155                 160 


Thr Asp Lys Ile Ile Glu Val Glu Glu Glu Gln Glu Asp Pro Tyr Leu 
                165                 170                 175     


Asn Asp Arg Cys Arg Gly Gly Gly Pro Cys Lys Gln Gln Cys Arg Asp 
            180                 185                 190         


Thr Gly Asp Glu Val Val Cys Ser Cys Phe Val Gly Tyr Gln Leu Leu 
        195                 200                 205             


Ser Asp Gly Val Ser Cys Glu Asp Val Asn Glu Cys Ile Thr Gly Ser 
    210                 215                 220                 


His Ser Cys Arg Leu Gly Glu Ser Cys Ile Asn Thr Val Gly Ser Phe 
225                 230                 235                 240 


Arg Cys Gln Arg Asp Ser Ser Cys Gly Thr Gly Tyr Glu Leu Thr Glu 
                245                 250                 255     


Asp Asn Ser Cys Lys Asp Ile Asp Glu Cys Glu Ser Gly Ile His Asn 
            260                 265                 270         


Cys Leu Pro Asp Phe Ile Cys Gln Asn Thr Leu Gly Ser Phe Arg Cys 
        275                 280                 285             


Arg Pro Lys Leu Gln Cys Lys Ser Gly Phe Ile Gln Asp Ala Leu Gly 
    290                 295                 300                 


Asn Cys Ile Asp Ile Asn Glu Cys Leu Ser Ile Ser Ala Pro Cys Pro 
305                 310                 315                 320 


Ile Gly His Thr Cys Ile Asn Thr Glu Gly Ser Tyr Thr Cys Gln Lys 
                325                 330                 335     


Asn Val Pro Asn Cys Gly Arg Gly Tyr His Leu Asn Glu Glu Gly Thr 
            340                 345                 350         


Arg Cys Val Asp Val Asp Glu Cys Ala Pro Pro Ala Glu Pro Cys Gly 
        355                 360                 365             


Lys Gly His Arg Cys Val Asn Ser Pro Gly Ser Phe Arg Cys Glu Cys 
    370                 375                 380                 


Lys Thr Gly Tyr Tyr Phe Asp Gly Ile Ser Arg Met Cys Val Asp Val 
385                 390                 395                 400 


Asn Glu Cys Gln Arg Tyr Pro Gly Arg Leu Cys Gly His Lys Cys Glu 
                405                 410                 415     


Asn Thr Leu Gly Ser Tyr Leu Cys Ser Cys Ser Val Gly Phe Arg Leu 
            420                 425                 430         


Ser Val Asp Gly Arg Ser Cys Glu Asp Ile Asn Glu Cys Ser Ser Ser 
        435                 440                 445             


Pro Cys Ser Gln Glu Cys Ala Asn Val Tyr Gly Ser Tyr Gln Cys Tyr 
    450                 455                 460                 


Cys Arg Arg Gly Tyr Gln Leu Ser Asp Val Asp Gly Val Thr Cys Glu 
465                 470                 475                 480 


Asp Ile Asp Glu Cys Ala Leu Pro Thr Gly Gly His Ile Cys Ser Tyr 
                485                 490                 495     


Arg Cys Ile Asn Ile Pro Gly Ser Phe Gln Cys Ser Cys Pro Ser Ser 
            500                 505                 510         


Gly Tyr Arg Leu Ala Pro Asn Gly Arg Asn Cys Gln Asp Ile Asp Glu 
        515                 520                 525             


Cys Val Thr Gly Ile His Asn Cys Ser Ile Asn Glu Thr Cys Phe Asn 
    530                 535                 540                 


Ile Gln Gly Gly Phe Arg Cys Leu Ala Phe Glu Cys Pro Glu Asn Tyr 
545                 550                 555                 560 


Arg Arg Ser Ala Ala Thr Leu Gln Gln Glu Lys Thr Asp Thr Val Arg 
                565                 570                 575     


Cys Ile Lys Ser Cys Arg Pro Asn Asp Val Thr Cys Val Phe Asp Pro 
            580                 585                 590         


Val His Thr Ile Ser His Thr Val Ile Ser Leu Pro Thr Phe Arg Glu 
        595                 600                 605             


Phe Thr Arg Pro Glu Glu Ile Ile Phe Leu Arg Ala Ile Thr Pro Pro 
    610                 615                 620                 


His Pro Ala Ser Gln Ala Asn Ile Ile Phe Asp Ile Thr Glu Gly Asn 
625                 630                 635                 640 


Leu Arg Asp Ser Phe Asp Ile Ile Lys Arg Tyr Met Asp Gly Met Thr 
                645                 650                 655     


Val Gly Val Val Arg Gln Val Arg Pro Ile Val Gly Pro Phe His Ala 
            660                 665                 670         


Val Leu Lys Leu Glu Met Asn Tyr Val Val Gly Gly Val Val Ser His 
        675                 680                 685             


Arg Asn Val Val Asn Val His Ile Phe Val Ser Glu Tyr Trp Phe 
    690                 695                 700             


<210>  5129
<211>  566
<212>  PRT
<213>  Homo Sapiens

<400>  5129

Met Glu Arg Ala Ala Pro Ser Arg Arg Val Pro Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Gly Gly Leu Ala Leu Leu Ala Ala Gly Val Asp Ala Asp Val Leu 
            20                  25                  30          


Leu Glu Ala Cys Cys Ala Asp Gly His Arg Met Ala Thr His Gln Lys 
        35                  40                  45              


Asp Cys Ser Leu Pro Tyr Ala Thr Glu Ser Lys Glu Cys Arg Met Val 
    50                  55                  60                  


Gln Glu Gln Cys Cys His Ser Gln Leu Glu Glu Leu His Cys Ala Thr 
65                  70                  75                  80  


Gly Ile Ser Leu Ala Asn Glu Gln Asp Arg Cys Ala Thr Pro His Gly 
                85                  90                  95      


Asp Asn Ala Ser Leu Glu Ala Thr Phe Val Lys Arg Cys Cys His Cys 
            100                 105                 110         


Cys Leu Leu Gly Arg Ala Ala Gln Ala Gln Gly Gln Ser Cys Glu Tyr 
        115                 120                 125             


Ser Leu Met Val Gly Tyr Gln Cys Gly Gln Val Phe Gln Ala Cys Cys 
    130                 135                 140                 


Val Lys Ser Gln Glu Thr Gly Asp Leu Asp Val Gly Gly Leu Gln Glu 
145                 150                 155                 160 


Thr Asp Lys Ile Ile Glu Val Glu Glu Glu Gln Glu Asp Pro Tyr Leu 
                165                 170                 175     


Asn Asp Arg Cys Arg Gly Gly Gly Pro Cys Lys Gln Gln Cys Arg Asp 
            180                 185                 190         


Thr Gly Asp Glu Val Val Cys Ser Cys Phe Val Gly Tyr Gln Leu Leu 
        195                 200                 205             


Ser Asp Gly Val Ser Cys Glu Asp Val Asn Glu Cys Ile Thr Gly Ser 
    210                 215                 220                 


His Ser Cys Arg Leu Gly Glu Ser Cys Ile Asn Thr Val Gly Ser Phe 
225                 230                 235                 240 


Arg Cys Gln Arg Asp Ser Ser Cys Gly Thr Gly Tyr Glu Leu Thr Glu 
                245                 250                 255     


Asp Asn Ser Cys Lys Asp Ile Asp Glu Cys Glu Ser Gly Ile His Asn 
            260                 265                 270         


Cys Leu Pro Asp Phe Ile Cys Gln Asn Thr Leu Gly Ser Phe Arg Cys 
        275                 280                 285             


Arg Pro Lys Leu Gln Cys Lys Ser Gly Phe Ile Gln Asp Ala Leu Gly 
    290                 295                 300                 


Asn Cys Ile Asp Ile Asn Glu Cys Leu Ser Ile Ser Ala Pro Cys Pro 
305                 310                 315                 320 


Ile Gly His Thr Cys Ile Asn Thr Glu Gly Ser Tyr Thr Cys Gln Lys 
                325                 330                 335     


Asn Val Pro Asn Cys Gly Arg Gly Tyr His Leu Asn Glu Glu Gly Thr 
            340                 345                 350         


Arg Cys Val Asp Val Asp Glu Cys Ala Pro Pro Ala Glu Pro Cys Gly 
        355                 360                 365             


Lys Gly His Arg Cys Val Asn Ser Pro Gly Ser Phe Arg Cys Glu Cys 
    370                 375                 380                 


Lys Thr Gly Tyr Tyr Phe Asp Gly Ile Ser Arg Met Cys Val Asp Val 
385                 390                 395                 400 


Asn Glu Cys Gln Arg Tyr Pro Gly Arg Leu Cys Gly His Lys Cys Glu 
                405                 410                 415     


Asn Thr Leu Gly Ser Tyr Leu Cys Ser Cys Ser Val Gly Phe Arg Leu 
            420                 425                 430         


Ser Val Asp Gly Arg Ser Cys Glu Asp Ile Asn Glu Cys Ser Ser Ser 
        435                 440                 445             


Pro Cys Ser Gln Glu Cys Ala Asn Val Tyr Gly Ser Tyr Gln Cys Tyr 
    450                 455                 460                 


Cys Arg Arg Gly Tyr Gln Leu Ser Asp Val Asp Gly Val Thr Cys Glu 
465                 470                 475                 480 


Asp Ile Asp Glu Cys Ala Leu Pro Thr Gly Gly His Ile Cys Ser Tyr 
                485                 490                 495     


Arg Cys Ile Asn Ile Pro Gly Ser Phe Gln Cys Ser Cys Pro Ser Ser 
            500                 505                 510         


Gly Tyr Arg Leu Ala Pro Asn Gly Arg Asn Cys Gln Asp Ile Asp Glu 
        515                 520                 525             


Cys Val Thr Gly Ile His Asn Cys Ser Ile Asn Glu Thr Cys Phe Asn 
    530                 535                 540                 


Ile Gln Gly Gly Phe Arg Cys Leu Ala Phe Glu Cys Pro Glu Asn Tyr 
545                 550                 555                 560 


Arg Arg Ser Ala Ala Thr 
                565     


<210>  5130
<211>  601
<212>  PRT
<213>  Homo Sapiens

<400>  5130

Met Glu Arg Ala Ala Pro Ser Arg Arg Val Pro Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Gly Gly Leu Ala Leu Leu Ala Ala Gly Val Asp Ala Asp Val Leu 
            20                  25                  30          


Leu Glu Ala Cys Cys Ala Asp Gly His Arg Met Ala Thr His Gln Lys 
        35                  40                  45              


Asp Cys Ser Leu Pro Tyr Ala Thr Glu Ser Lys Glu Cys Arg Met Val 
    50                  55                  60                  


Gln Glu Gln Cys Cys His Ser Gln Leu Glu Glu Leu His Cys Ala Thr 
65                  70                  75                  80  


Gly Ile Ser Leu Ala Asn Glu Gln Asp Arg Cys Ala Thr Pro His Gly 
                85                  90                  95      


Asp Asn Ala Ser Leu Glu Ala Thr Phe Val Lys Arg Cys Cys His Cys 
            100                 105                 110         


Cys Leu Leu Gly Arg Ala Ala Gln Ala Gln Gly Gln Ser Cys Glu Tyr 
        115                 120                 125             


Ser Leu Met Val Gly Tyr Gln Cys Gly Gln Val Phe Gln Ala Cys Cys 
    130                 135                 140                 


Val Lys Ser Gln Glu Thr Gly Asp Leu Asp Val Gly Gly Leu Gln Glu 
145                 150                 155                 160 


Thr Asp Lys Ile Ile Glu Val Glu Glu Glu Gln Glu Asp Pro Tyr Leu 
                165                 170                 175     


Asn Asp Arg Cys Arg Gly Gly Gly Pro Cys Lys Gln Gln Cys Arg Asp 
            180                 185                 190         


Thr Gly Asp Glu Val Val Cys Ser Cys Phe Val Gly Tyr Gln Leu Leu 
        195                 200                 205             


Ser Asp Gly Val Ser Cys Glu Asp Val Asn Glu Cys Ile Thr Gly Ser 
    210                 215                 220                 


His Ser Cys Arg Leu Gly Glu Ser Cys Ile Asn Thr Val Gly Ser Phe 
225                 230                 235                 240 


Arg Cys Gln Arg Asp Ser Ser Cys Gly Thr Gly Tyr Glu Leu Thr Glu 
                245                 250                 255     


Asp Asn Ser Cys Lys Asp Ile Asp Glu Cys Glu Ser Gly Ile His Asn 
            260                 265                 270         


Cys Leu Pro Asp Phe Ile Cys Gln Asn Thr Leu Gly Ser Phe Arg Cys 
        275                 280                 285             


Arg Pro Lys Leu Gln Cys Lys Ser Gly Phe Ile Gln Asp Ala Leu Gly 
    290                 295                 300                 


Asn Cys Ile Asp Ile Asn Glu Cys Leu Ser Ile Ser Ala Pro Cys Pro 
305                 310                 315                 320 


Ile Gly His Thr Cys Ile Asn Thr Glu Gly Ser Tyr Thr Cys Gln Lys 
                325                 330                 335     


Asn Val Pro Asn Cys Gly Arg Gly Tyr His Leu Asn Glu Glu Gly Thr 
            340                 345                 350         


Arg Cys Val Asp Val Asp Glu Cys Ala Pro Pro Ala Glu Pro Cys Gly 
        355                 360                 365             


Lys Gly His Arg Cys Val Asn Ser Pro Gly Ser Phe Arg Cys Glu Cys 
    370                 375                 380                 


Lys Thr Gly Tyr Tyr Phe Asp Gly Ile Ser Arg Met Cys Val Asp Val 
385                 390                 395                 400 


Asn Glu Cys Gln Arg Tyr Pro Gly Arg Leu Cys Gly His Lys Cys Glu 
                405                 410                 415     


Asn Thr Leu Gly Ser Tyr Leu Cys Ser Cys Ser Val Gly Phe Arg Leu 
            420                 425                 430         


Ser Val Asp Gly Arg Ser Cys Glu Asp Ile Asn Glu Cys Ser Ser Ser 
        435                 440                 445             


Pro Cys Ser Gln Glu Cys Ala Asn Val Tyr Gly Ser Tyr Gln Cys Tyr 
    450                 455                 460                 


Cys Arg Arg Gly Tyr Gln Leu Ser Asp Val Asp Gly Val Thr Cys Glu 
465                 470                 475                 480 


Asp Ile Asp Glu Cys Ala Leu Pro Thr Gly Gly His Ile Cys Ser Tyr 
                485                 490                 495     


Arg Cys Ile Asn Ile Pro Gly Ser Phe Gln Cys Ser Cys Pro Ser Ser 
            500                 505                 510         


Gly Tyr Arg Leu Ala Pro Asn Gly Arg Asn Cys Gln Asp Ile Asp Glu 
        515                 520                 525             


Cys Val Thr Gly Ile His Asn Cys Ser Ile Asn Glu Thr Cys Phe Asn 
    530                 535                 540                 


Ile Gln Gly Gly Phe Arg Cys Leu Ala Phe Glu Cys Pro Glu Asn Tyr 
545                 550                 555                 560 


Arg Arg Ser Ala Ala Thr Gln Lys Ser Lys Lys Gly Arg Gln Asn Thr 
                565                 570                 575     


Pro Ala Gly Ser Ser Lys Glu Asp Cys Arg Val Leu Pro Trp Lys Gln 
            580                 585                 590         


Gly Leu Glu Asp Thr His Leu Asp Ala 
        595                 600     


<210>  5131
<211>  172
<212>  PRT
<213>  Homo Sapiens

<400>  5131

Met Glu Arg Ala Ala Pro Ser Arg Arg Val Pro Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Gly Gly Leu Ala Leu Leu Ala Ala Gly Val Asp Ala Asp Val Leu 
            20                  25                  30          


Leu Glu Ala Cys Cys Ala Asp Gly His Arg Met Ala Thr His Gln Lys 
        35                  40                  45              


Asp Cys Ser Leu Pro Tyr Ala Thr Glu Ser Lys Glu Cys Arg Met Val 
    50                  55                  60                  


Gln Glu Gln Cys Cys His Ser Gln Leu Glu Glu Leu His Cys Ala Thr 
65                  70                  75                  80  


Gly Ile Ser Leu Ala Asn Glu Gln Asp Arg Cys Ala Thr Pro His Gly 
                85                  90                  95      


Asp Asn Ala Ser Leu Glu Ala Thr Phe Val Lys Arg Cys Cys His Cys 
            100                 105                 110         


Cys Leu Leu Gly Arg Ala Ala Gln Ala Gln Gly Gln Ser Cys Glu Tyr 
        115                 120                 125             


Ser Leu Met Val Gly Tyr Gln Cys Gly Gln Val Phe Gln Ala Cys Cys 
    130                 135                 140                 


Val Lys Ser Gln Glu Thr Gly Asp Leu Asp Val Gly Gly Leu Gln Glu 
145                 150                 155                 160 


Thr Gly Gly Gly Pro Cys Lys Gln Gln Cys Arg Asp 
                165                 170         


<210>  5132
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  5132

Met Asn Ser Tyr Thr Arg Gly Ser Arg Arg Pro Ser Ala Lys Ala Ala 
1               5                   10                  15      


Ser Pro Ala Ala Ser Val Thr Ser Arg Val Ser Pro Ser Gly Pro Gly 
            20                  25                  30          


Val Pro Val Asp Ala Asp Val Leu Leu Glu Ala Cys Cys Ala Asp Gly 
        35                  40                  45              


His Arg Met Ala Thr His Gln Lys Asp Cys Ser Leu Pro Tyr Ala Thr 
    50                  55                  60                  


Glu Ser Lys Glu Cys Arg Met Val Gln Glu Gln Cys Cys His Ser Gln 
65                  70                  75                  80  


Leu Glu Glu Leu His Cys Ala Thr Gly Ile Ser Leu Ala Asn Glu Gln 
                85                  90                  95      


Asp Arg Cys Ala Thr Pro His Gly Asp Asn Ala Ser Leu Glu Ala Thr 
            100                 105                 110         


Phe Val Lys Arg Cys Cys His Cys Cys Leu Leu Gly Arg Ala Ala Gln 
        115                 120                 125             


Ala Gln Gly Gln Ser Cys Glu Tyr Ser Leu Met Val Gly Tyr Gln Cys 
    130                 135                 140                 


Gly Gln Val Phe Gln Ala Cys Cys Val Lys Ser Gln Glu Thr Gly Asp 
145                 150                 155                 160 


Leu Asp Val Gly Gly Leu Gln Glu Thr Asp Lys Ile Ile Glu Val Glu 
                165                 170                 175     


Glu Glu Gln Glu Asp Pro Tyr Leu Asn Asp Arg Cys Arg 
            180                 185                 


<210>  5133
<211>  183
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5133

Xaa Lys Arg Cys Cys His Cys Cys Leu Leu Gly Arg Ala Ala Gln Ala 
1               5                   10                  15      


Gln Gly Gln Ser Cys Glu Tyr Ser Leu Met Val Gly Tyr Gln Cys Gly 
            20                  25                  30          


Gln Val Phe Gln Ala Cys Cys Val Lys Ser Gln Glu Thr Gly Asp Leu 
        35                  40                  45              


Asp Val Gly Gly Leu Gln Glu Thr Asp Lys Ile Ile Glu Val Glu Glu 
    50                  55                  60                  


Glu Gln Glu Asp Pro Tyr Leu Asn Asp Arg Cys Arg Gly Gly Gly Pro 
65                  70                  75                  80  


Cys Lys Gln Gln Cys Arg Asp Thr Gly Asp Glu Val Val Cys Ser Cys 
                85                  90                  95      


Phe Val Gly Tyr Gln Leu Leu Ser Asp Gly Val Ser Cys Glu Asp Val 
            100                 105                 110         


Asn Glu Cys Ile Thr Gly Ser His Ser Cys Arg Leu Gly Glu Ser Cys 
        115                 120                 125             


Ile Asn Thr Val Gly Ser Phe Arg Cys Gln Arg Asp Ser Ser Cys Gly 
    130                 135                 140                 


Thr Gly Tyr Glu Leu Thr Glu Asp Asn Ser Cys Lys Glu Tyr Ser Gly 
145                 150                 155                 160 


Ile Leu Pro Leu Pro Thr Gln Ala Thr Val Gln Glu Trp Leu Tyr Thr 
                165                 170                 175     


Arg Cys Ser Arg Gln Leu Tyr 
            180             


<210>  5134
<211>  159
<212>  PRT
<213>  Homo Sapiens

<400>  5134

Met Val Leu Leu Trp Glu Pro Ala Gly Ala Trp Leu Ala Leu Gly Leu 
1               5                   10                  15      


Ala Leu Ala Leu Gly Pro Ser Val Ala Ala Ala Ala Pro Arg Gln Asp 
            20                  25                  30          


Cys Thr Gly Val Glu Cys Pro Pro Leu Glu Asn Cys Ile Glu Glu Ala 
        35                  40                  45              


Leu Glu Pro Gly Ala Cys Cys Ala Thr Cys Val Gln Gln Gly Cys Ala 
    50                  55                  60                  


Cys Glu Gly Tyr Gln Tyr Tyr Asp Cys Leu Gln Gly Gly Phe Val Arg 
65                  70                  75                  80  


Gly Arg Val Pro Ala Gly Gln Ser Tyr Phe Val Asp Phe Gly Ser Thr 
                85                  90                  95      


Glu Cys Ser Cys Pro Pro Gly Gly Gly Lys Ile Ser Cys Gln Phe Met 
            100                 105                 110         


Leu Cys Pro Glu Leu Pro Pro Asn Cys Ile Glu Ala Val Val Val Ala 
        115                 120                 125             


Asp Ser Cys Pro Gln Cys Gly Gln Val Gly Cys Val His Ala Gly His 
    130                 135                 140                 


Lys Tyr Ala Ala Gly His Thr Val His Leu Pro Pro Cys Arg Ala 
145                 150                 155                 


<210>  5135
<211>  1184
<212>  PRT
<213>  Homo Sapiens

<400>  5135

Met Val Leu Leu Trp Glu Pro Ala Gly Ala Trp Leu Ala Leu Gly Leu 
1               5                   10                  15      


Ala Leu Ala Leu Gly Pro Ser Val Ala Ala Ala Ala Pro Arg Gln Asp 
            20                  25                  30          


Cys Thr Gly Val Glu Cys Pro Pro Leu Glu Asn Cys Ile Glu Glu Ala 
        35                  40                  45              


Leu Glu Pro Gly Ala Cys Cys Ala Thr Cys Val Gln Gln Gly Cys Ala 
    50                  55                  60                  


Cys Glu Gly Tyr Gln Tyr Tyr Asp Cys Leu Gln Gly Gly Phe Val Arg 
65                  70                  75                  80  


Gly Arg Val Pro Ala Gly Gln Ser Tyr Phe Val Asp Phe Gly Ser Thr 
                85                  90                  95      


Glu Cys Ser Cys Pro Pro Gly Gly Gly Lys Ile Ser Cys Gln Phe Met 
            100                 105                 110         


Leu Cys Pro Glu Leu Pro Pro Asn Cys Ile Glu Ala Val Val Val Ala 
        115                 120                 125             


Asp Ser Cys Pro Gln Cys Gly Gln Val Gly Cys Val His Ala Gly His 
    130                 135                 140                 


Lys Tyr Ala Ala Gly His Thr Val His Leu Pro Pro Cys Arg Ala Cys 
145                 150                 155                 160 


His Cys Pro Asp Ala Gly Gly Glu Leu Ile Cys Tyr Gln Leu Pro Gly 
                165                 170                 175     


Cys His Gly Asn Phe Ser Asp Ala Glu Glu Gly Asp Pro Glu Arg His 
            180                 185                 190         


Tyr Glu Asp Pro Tyr Ser Tyr Asp Gln Glu Val Ala Glu Val Glu Ala 
        195                 200                 205             


Ala Thr Ala Leu Gly Gly Glu Val Gln Ala Gly Ala Val Gln Ala Gly 
    210                 215                 220                 


Ala Gly Gly Pro Pro Ala Ala Leu Gly Gly Gly Ser Gln Pro Leu Ser 
225                 230                 235                 240 


Thr Ile Gln Ala Pro Pro Trp Pro Ala Val Leu Pro Arg Pro Thr Ala 
                245                 250                 255     


Ala Ala Ala Leu Gly Pro Pro Ala Pro Val Gln Ala Lys Ala Arg Arg 
            260                 265                 270         


Val Thr Glu Asp Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Arg Glu 
        275                 280                 285             


Glu Met Ala Val Thr Glu Gln Leu Ala Ala Gly Gly His Arg Gly Leu 
    290                 295                 300                 


Asp Gly Leu Pro Thr Thr Ala Pro Ala Gly Pro Ser Leu Pro Ile Gln 
305                 310                 315                 320 


Glu Glu Arg Ala Glu Ala Gly Ala Arg Ala Glu Ala Gly Ala Arg Pro 
                325                 330                 335     


Glu Glu Asn Leu Ile Leu Asp Ala Gln Ala Thr Ser Arg Ser Thr Gly 
            340                 345                 350         


Pro Glu Gly Val Thr His Ala Pro Ser Leu Gly Lys Ala Ala Leu Val 
        355                 360                 365             


Pro Thr Gln Ala Val Pro Gly Ser Pro Arg Asp Pro Val Lys Pro Ser 
    370                 375                 380                 


Pro His Asn Ile Leu Ser Thr Ser Leu Pro Asp Ala Ala Trp Ile Pro 
385                 390                 395                 400 


Pro Thr Arg Glu Val Pro Arg Lys Pro Gln Val Leu Pro His Ser His 
                405                 410                 415     


Val Glu Glu Asp Thr Asp Pro Asn Ser Val His Ser Ile Pro Arg Ser 
            420                 425                 430         


Ser Pro Glu Gly Ser Thr Lys Asp Leu Ile Glu Thr Cys Cys Ala Ala 
        435                 440                 445             


Gly Gln Gln Trp Ala Ile Asp Asn Asp Glu Cys Leu Glu Ile Pro Glu 
    450                 455                 460                 


Ser Gly Thr Glu Asp Asn Val Cys Arg Thr Ala Gln Arg His Cys Cys 
465                 470                 475                 480 


Val Ser Tyr Leu Gln Glu Lys Ser Cys Met Ala Gly Val Leu Gly Ala 
                485                 490                 495     


Lys Glu Gly Glu Thr Cys Gly Ala Glu Asp Asn Asp Ser Cys Gly Ile 
            500                 505                 510         


Ser Leu Tyr Lys Gln Cys Cys Asp Cys Cys Gly Leu Gly Leu Arg Val 
        515                 520                 525             


Arg Ala Glu Gly Gln Ser Cys Glu Ser Asn Pro Asn Leu Gly Tyr Pro 
    530                 535                 540                 


Cys Asn His Val Met Leu Ser Cys Cys Glu Gly Glu Glu Pro Leu Ile 
545                 550                 555                 560 


Val Pro Glu Val Arg Arg Pro Pro Glu Pro Ala Ala Ala Pro Arg Arg 
                565                 570                 575     


Val Ser Glu Ala Glu Met Ala Gly Arg Glu Ala Leu Ser Leu Gly Thr 
            580                 585                 590         


Glu Ala Glu Leu Pro Asn Ser Leu Pro Gly Asp Asp Gln Asp Glu Cys 
        595                 600                 605             


Leu Leu Leu Pro Gly Glu Leu Cys Gln His Leu Cys Ile Asn Thr Val 
    610                 615                 620                 


Gly Ser Tyr His Cys Ala Cys Phe Pro Gly Phe Ser Leu Gln Asp Asp 
625                 630                 635                 640 


Gly Arg Thr Cys Arg Pro Glu Gly His Pro Pro Gln Pro Glu Ala Pro 
                645                 650                 655     


Gln Glu Pro Ala Leu Lys Ser Glu Phe Ser Gln Val Ala Ser Asn Thr 
            660                 665                 670         


Ile Pro Leu Pro Leu Pro Gln Pro Asn Thr Cys Lys Asp Asn Gly Pro 
        675                 680                 685             


Cys Lys Gln Val Cys Ser Thr Val Gly Gly Ser Ala Ile Cys Ser Cys 
    690                 695                 700                 


Phe Pro Gly Tyr Ala Ile Met Ala Asp Gly Val Ser Cys Glu Asp Ile 
705                 710                 715                 720 


Asn Glu Cys Val Thr Asp Leu His Thr Cys Ser Arg Gly Glu His Cys 
                725                 730                 735     


Val Asn Thr Leu Gly Ser Phe His Cys Tyr Lys Ala Leu Thr Cys Glu 
            740                 745                 750         


Pro Gly Tyr Ala Leu Lys Asp Gly Glu Cys Glu Asp Val Asp Glu Cys 
        755                 760                 765             


Ala Met Gly Thr His Thr Cys Gln Pro Gly Phe Leu Cys Gln Asn Thr 
    770                 775                 780                 


Lys Gly Ser Phe Tyr Cys Gln Ala Arg Gln Arg Cys Met Asp Gly Phe 
785                 790                 795                 800 


Leu Gln Asp Pro Glu Gly Asn Cys Val Asp Ile Asn Glu Cys Thr Ser 
                805                 810                 815     


Leu Ser Glu Pro Cys Arg Pro Gly Phe Ser Cys Ile Asn Thr Val Gly 
            820                 825                 830         


Ser Tyr Thr Cys Gln Arg Asn Pro Leu Ile Cys Ala Arg Gly Tyr His 
        835                 840                 845             


Ala Ser Asp Asp Gly Thr Lys Cys Val Asp Val Asn Glu Cys Glu Thr 
    850                 855                 860                 


Gly Val His Arg Cys Gly Glu Gly Gln Val Cys His Asn Leu Pro Gly 
865                 870                 875                 880 


Ser Tyr Arg Cys Asp Cys Lys Ala Gly Phe Gln Arg Asp Ala Phe Gly 
                885                 890                 895     


Arg Gly Cys Ile Asp Val Asn Glu Cys Trp Ala Ser Pro Gly Arg Leu 
            900                 905                 910         


Cys Gln His Thr Cys Glu Asn Thr Leu Gly Ser Tyr Arg Cys Ser Cys 
        915                 920                 925             


Ala Ser Gly Phe Leu Leu Ala Ala Asp Gly Lys Arg Cys Glu Asp Val 
    930                 935                 940                 


Asn Glu Cys Glu Ala Gln Arg Cys Ser Gln Glu Cys Ala Asn Ile Tyr 
945                 950                 955                 960 


Gly Ser Tyr Gln Cys Tyr Cys Arg Gln Gly Tyr Gln Leu Ala Glu Asp 
                965                 970                 975     


Gly His Thr Cys Thr Asp Ile Asp Glu Cys Ala Gln Gly Ala Gly Ile 
            980                 985                 990         


Leu Cys Thr Phe Arg Cys Leu Asn  Val Pro Gly Ser Tyr  Gln Cys Ala 
        995                 1000                 1005             


Cys Pro  Glu Gln Gly Tyr Thr  Met Thr Ala Asn Gly  Arg Ser Cys 
    1010                 1015                 1020             


Lys Asp  Val Asp Glu Cys Ala  Leu Gly Thr His Asn  Cys Ser Glu 
    1025                 1030                 1035             


Ala Glu  Thr Cys His Asn Ile  Gln Gly Ser Phe Arg  Cys Leu Arg 
    1040                 1045                 1050             


Phe Glu  Cys Pro Pro Asn Tyr  Val Gln Val Ser Lys  Thr Lys Cys 
    1055                 1060                 1065             


Glu Arg  Thr Thr Cys His Asp  Phe Leu Glu Cys Gln  Asn Ser Pro 
    1070                 1075                 1080             


Ala Arg  Ile Thr His Tyr Gln  Leu Asn Phe Gln Thr  Gly Leu Leu 
    1085                 1090                 1095             


Val Pro  Ala His Ile Phe Arg  Ile Gly Pro Ala Pro  Ala Phe Thr 
    1100                 1105                 1110             


Gly Asp  Thr Ile Ala Leu Asn  Ile Ile Lys Gly Asn  Glu Glu Gly 
    1115                 1120                 1125             


Tyr Phe  Gly Thr Arg Arg Leu  Asn Ala Tyr Thr Gly  Val Val Tyr 
    1130                 1135                 1140             


Leu Gln  Arg Ala Val Leu Glu  Pro Arg Asp Phe Ala  Leu Asp Val 
    1145                 1150                 1155             


Glu Met  Lys Leu Trp Arg Gln  Gly Ser Val Thr Thr  Phe Leu Ala 
    1160                 1165                 1170             


Lys Met  His Ile Phe Phe Thr  Thr Phe Ala Leu 
    1175                 1180                 


<210>  5136
<211>  1231
<212>  PRT
<213>  Homo Sapiens

<400>  5136

Met Val Leu Leu Trp Glu Pro Ala Gly Ala Trp Leu Ala Leu Gly Leu 
1               5                   10                  15      


Ala Leu Ala Leu Gly Pro Ser Val Ala Ala Ala Ala Pro Arg Gln Asp 
            20                  25                  30          


Cys Thr Gly Val Glu Cys Pro Pro Leu Glu Asn Cys Ile Glu Glu Ala 
        35                  40                  45              


Leu Glu Pro Gly Ala Cys Cys Ala Thr Cys Val Gln Gln Gly Cys Ala 
    50                  55                  60                  


Cys Glu Gly Tyr Gln Tyr Tyr Asp Cys Leu Gln Gly Gly Phe Val Arg 
65                  70                  75                  80  


Gly Arg Val Pro Ala Gly Gln Ser Tyr Phe Val Asp Phe Gly Ser Thr 
                85                  90                  95      


Glu Cys Ser Cys Pro Pro Gly Gly Gly Lys Ile Ser Cys Gln Phe Met 
            100                 105                 110         


Leu Cys Pro Glu Leu Pro Pro Asn Cys Ile Glu Ala Val Val Val Ala 
        115                 120                 125             


Asp Ser Cys Pro Gln Cys Gly Gln Val Gly Cys Val His Ala Gly His 
    130                 135                 140                 


Lys Tyr Ala Ala Gly His Thr Val His Leu Pro Pro Cys Arg Ala Cys 
145                 150                 155                 160 


His Cys Pro Asp Ala Gly Gly Glu Leu Ile Cys Tyr Gln Leu Pro Gly 
                165                 170                 175     


Cys His Gly Asn Phe Ser Asp Ala Glu Glu Gly Asp Pro Glu Arg His 
            180                 185                 190         


Tyr Glu Asp Pro Tyr Ser Tyr Asp Gln Glu Val Ala Glu Val Glu Ala 
        195                 200                 205             


Ala Thr Ala Leu Gly Gly Glu Val Gln Ala Gly Ala Val Gln Ala Gly 
    210                 215                 220                 


Ala Gly Gly Pro Pro Ala Ala Leu Gly Gly Gly Ser Gln Pro Leu Ser 
225                 230                 235                 240 


Thr Ile Gln Ala Pro Pro Trp Pro Ala Val Leu Pro Arg Pro Thr Ala 
                245                 250                 255     


Ala Ala Ala Leu Gly Pro Pro Ala Pro Val Gln Ala Lys Ala Arg Arg 
            260                 265                 270         


Val Thr Glu Asp Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Arg Glu 
        275                 280                 285             


Glu Met Ala Val Thr Glu Gln Leu Ala Ala Gly Gly His Arg Gly Leu 
    290                 295                 300                 


Asp Gly Leu Pro Thr Thr Ala Pro Ala Gly Pro Ser Leu Pro Ile Gln 
305                 310                 315                 320 


Glu Glu Arg Ala Glu Ala Gly Ala Arg Ala Glu Ala Gly Ala Arg Pro 
                325                 330                 335     


Glu Glu Asn Leu Ile Leu Asp Ala Gln Ala Thr Ser Arg Ser Thr Gly 
            340                 345                 350         


Pro Glu Gly Val Thr His Ala Pro Ser Leu Gly Lys Ala Ala Leu Val 
        355                 360                 365             


Pro Thr Gln Ala Val Pro Gly Ser Pro Arg Asp Pro Val Lys Pro Ser 
    370                 375                 380                 


Pro His Asn Ile Leu Ser Thr Ser Leu Pro Asp Ala Ala Trp Ile Pro 
385                 390                 395                 400 


Pro Thr Arg Glu Val Pro Arg Lys Pro Gln Val Leu Pro His Ser His 
                405                 410                 415     


Val Glu Glu Asp Thr Asp Pro Asn Ser Val His Ser Ile Pro Arg Ser 
            420                 425                 430         


Ser Pro Glu Gly Ser Thr Lys Asp Leu Ile Glu Thr Cys Cys Ala Ala 
        435                 440                 445             


Gly Gln Gln Trp Ala Ile Asp Asn Asp Glu Cys Leu Glu Ile Pro Glu 
    450                 455                 460                 


Ser Gly Thr Glu Asp Asn Val Cys Arg Thr Ala Gln Arg His Cys Cys 
465                 470                 475                 480 


Val Ser Tyr Leu Gln Glu Lys Ser Cys Met Ala Gly Val Leu Gly Ala 
                485                 490                 495     


Lys Glu Gly Glu Thr Cys Gly Ala Glu Asp Asn Asp Ser Cys Gly Ile 
            500                 505                 510         


Ser Leu Tyr Lys Gln Cys Cys Asp Cys Cys Gly Leu Gly Leu Arg Val 
        515                 520                 525             


Arg Ala Glu Gly Gln Ser Cys Glu Ser Asn Pro Asn Leu Gly Tyr Pro 
    530                 535                 540                 


Cys Asn His Val Met Leu Ser Cys Cys Glu Gly Glu Glu Pro Leu Ile 
545                 550                 555                 560 


Val Pro Glu Val Arg Arg Pro Pro Glu Pro Ala Ala Ala Pro Arg Arg 
                565                 570                 575     


Val Ser Glu Ala Glu Met Ala Gly Arg Glu Ala Leu Ser Leu Gly Thr 
            580                 585                 590         


Glu Ala Glu Leu Pro Asn Ser Leu Pro Gly Asp Asp Gln Asp Glu Cys 
        595                 600                 605             


Leu Leu Leu Pro Gly Glu Leu Cys Gln His Leu Cys Ile Asn Thr Val 
    610                 615                 620                 


Gly Ser Tyr His Cys Ala Cys Phe Pro Gly Phe Ser Leu Gln Asp Asp 
625                 630                 635                 640 


Gly Arg Thr Cys Arg Pro Glu Gly His Pro Pro Gln Pro Glu Ala Pro 
                645                 650                 655     


Gln Glu Pro Ala Leu Lys Ser Glu Phe Ser Gln Val Ala Ser Asn Thr 
            660                 665                 670         


Ile Pro Leu Pro Leu Pro Gln Pro Asn Thr Cys Lys Asp Asn Gly Pro 
        675                 680                 685             


Cys Lys Gln Val Cys Ser Thr Val Gly Gly Ser Ala Ile Cys Ser Cys 
    690                 695                 700                 


Phe Pro Gly Tyr Ala Ile Met Ala Asp Gly Val Ser Cys Glu Asp Gln 
705                 710                 715                 720 


Asp Glu Cys Leu Met Gly Ala His Asp Cys Ser Arg Arg Gln Phe Cys 
                725                 730                 735     


Val Asn Thr Leu Gly Ser Phe Tyr Cys Val Asn His Thr Val Leu Cys 
            740                 745                 750         


Ala Asp Gly Tyr Ile Leu Asn Ala His Arg Lys Cys Val Asp Ile Asn 
        755                 760                 765             


Glu Cys Val Thr Asp Leu His Thr Cys Ser Arg Gly Glu His Cys Val 
    770                 775                 780                 


Asn Thr Leu Gly Ser Phe His Cys Tyr Lys Ala Leu Thr Cys Glu Pro 
785                 790                 795                 800 


Gly Tyr Ala Leu Lys Asp Gly Glu Cys Glu Asp Val Asp Glu Cys Ala 
                805                 810                 815     


Met Gly Thr His Thr Cys Gln Pro Gly Phe Leu Cys Gln Asn Thr Lys 
            820                 825                 830         


Gly Ser Phe Tyr Cys Gln Ala Arg Gln Arg Cys Met Asp Gly Phe Leu 
        835                 840                 845             


Gln Asp Pro Glu Gly Asn Cys Val Asp Ile Asn Glu Cys Thr Ser Leu 
    850                 855                 860                 


Ser Glu Pro Cys Arg Pro Gly Phe Ser Cys Ile Asn Thr Val Gly Ser 
865                 870                 875                 880 


Tyr Thr Cys Gln Arg Asn Pro Leu Ile Cys Ala Arg Gly Tyr His Ala 
                885                 890                 895     


Ser Asp Asp Gly Thr Lys Cys Val Asp Val Asn Glu Cys Glu Thr Gly 
            900                 905                 910         


Val His Arg Cys Gly Glu Gly Gln Val Cys His Asn Leu Pro Gly Ser 
        915                 920                 925             


Tyr Arg Cys Asp Cys Lys Ala Gly Phe Gln Arg Asp Ala Phe Gly Arg 
    930                 935                 940                 


Gly Cys Ile Asp Val Asn Glu Cys Trp Ala Ser Pro Gly Arg Leu Cys 
945                 950                 955                 960 


Gln His Thr Cys Glu Asn Thr Leu Gly Ser Tyr Arg Cys Ser Cys Ala 
                965                 970                 975     


Ser Gly Phe Leu Leu Ala Ala Asp Gly Lys Arg Cys Glu Asp Val Asn 
            980                 985                 990         


Glu Cys Glu Ala Gln Arg Cys Ser  Gln Glu Cys Ala Asn  Ile Tyr Gly 
        995                 1000                 1005             


Ser Tyr  Gln Cys Tyr Cys Arg  Gln Gly Tyr Gln Leu  Ala Glu Asp 
    1010                 1015                 1020             


Gly His  Thr Cys Thr Asp Ile  Asp Glu Cys Ala Gln  Gly Ala Gly 
    1025                 1030                 1035             


Ile Leu  Cys Thr Phe Arg Cys  Leu Asn Val Pro Gly  Ser Tyr Gln 
    1040                 1045                 1050             


Cys Ala  Cys Pro Glu Gln Gly  Tyr Thr Met Thr Ala  Asn Gly Arg 
    1055                 1060                 1065             


Ser Cys  Lys Asp Val Asp Glu  Cys Ala Leu Gly Thr  His Asn Cys 
    1070                 1075                 1080             


Ser Glu  Ala Glu Thr Cys His  Asn Ile Gln Gly Ser  Phe Arg Cys 
    1085                 1090                 1095             


Leu Arg  Phe Glu Cys Pro Pro  Asn Tyr Val Gln Val  Ser Lys Thr 
    1100                 1105                 1110             


Lys Cys  Glu Arg Thr Thr Cys  His Asp Phe Leu Glu  Cys Gln Asn 
    1115                 1120                 1125             


Ser Pro  Ala Arg Ile Thr His  Tyr Gln Leu Asn Phe  Gln Thr Gly 
    1130                 1135                 1140             


Leu Leu  Val Pro Ala His Ile  Phe Arg Ile Gly Pro  Ala Pro Ala 
    1145                 1150                 1155             


Phe Thr  Gly Asp Thr Ile Ala  Leu Asn Ile Ile Lys  Gly Asn Glu 
    1160                 1165                 1170             


Glu Gly  Tyr Phe Gly Thr Arg  Arg Leu Asn Ala Tyr  Thr Gly Val 
    1175                 1180                 1185             


Val Tyr  Leu Gln Arg Ala Val  Leu Glu Pro Arg Asp  Phe Ala Leu 
    1190                 1195                 1200             


Asp Val  Glu Met Lys Leu Trp  Arg Gln Gly Ser Val  Thr Thr Phe 
    1205                 1210                 1215             


Leu Ala  Lys Met His Ile Phe  Phe Thr Thr Phe Ala  Leu 
    1220                 1225                 1230     


<210>  5137
<211>  1231
<212>  PRT
<213>  Homo Sapiens

<400>  5137

Met Val Leu Leu Trp Glu Pro Ala Gly Ala Trp Leu Ala Leu Gly Leu 
1               5                   10                  15      


Ala Leu Ala Leu Gly Pro Ser Val Ala Ala Ala Ala Pro Arg Gln Asp 
            20                  25                  30          


Cys Thr Gly Val Glu Cys Pro Pro Leu Glu Asn Cys Ile Glu Glu Ala 
        35                  40                  45              


Leu Glu Pro Gly Ala Cys Cys Ala Thr Cys Val Gln Gln Gly Cys Ala 
    50                  55                  60                  


Cys Glu Gly Tyr Gln Tyr Tyr Asp Cys Leu Gln Gly Gly Phe Val Arg 
65                  70                  75                  80  


Gly Arg Val Pro Ala Gly Gln Ser Tyr Phe Val Asp Phe Gly Ser Thr 
                85                  90                  95      


Glu Cys Ser Cys Pro Pro Gly Gly Gly Lys Ile Ser Cys Gln Phe Met 
            100                 105                 110         


Leu Cys Pro Glu Leu Pro Pro Asn Cys Ile Glu Ala Val Val Val Ala 
        115                 120                 125             


Asp Ser Cys Pro Gln Cys Gly Gln Val Gly Cys Val His Ala Gly His 
    130                 135                 140                 


Lys Tyr Ala Ala Gly His Thr Val His Leu Pro Pro Cys Arg Ala Cys 
145                 150                 155                 160 


His Cys Pro Asp Ala Gly Gly Glu Leu Ile Cys Tyr Gln Leu Pro Gly 
                165                 170                 175     


Cys His Gly Asn Phe Ser Asp Ala Glu Glu Gly Asp Pro Glu Arg His 
            180                 185                 190         


Tyr Glu Asp Pro Tyr Ser Tyr Asp Gln Glu Val Ala Glu Val Glu Ala 
        195                 200                 205             


Ala Thr Ala Leu Gly Gly Glu Val Gln Ala Gly Ala Val Gln Ala Gly 
    210                 215                 220                 


Ala Gly Gly Pro Pro Ala Ala Leu Gly Gly Gly Ser Gln Pro Leu Ser 
225                 230                 235                 240 


Thr Ile Gln Ala Pro Pro Trp Pro Ala Val Leu Pro Arg Pro Thr Ala 
                245                 250                 255     


Ala Ala Ala Leu Gly Pro Pro Ala Pro Val Gln Ala Lys Ala Arg Arg 
            260                 265                 270         


Val Thr Glu Asp Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Arg Glu 
        275                 280                 285             


Glu Met Ala Val Thr Glu Gln Leu Ala Ala Gly Gly His Arg Gly Leu 
    290                 295                 300                 


Asp Gly Leu Pro Thr Thr Ala Pro Ala Gly Pro Ser Leu Pro Ile Gln 
305                 310                 315                 320 


Glu Glu Arg Ala Glu Ala Gly Ala Arg Ala Glu Ala Gly Ala Arg Pro 
                325                 330                 335     


Glu Glu Asn Leu Ile Leu Asp Ala Gln Ala Thr Ser Arg Ser Thr Gly 
            340                 345                 350         


Pro Glu Gly Val Thr His Ala Pro Ser Leu Gly Lys Ala Ala Leu Val 
        355                 360                 365             


Pro Thr Gln Ala Val Pro Gly Ser Pro Arg Asp Pro Val Lys Pro Ser 
    370                 375                 380                 


Pro His Asn Ile Leu Ser Thr Ser Leu Pro Asp Ala Ala Trp Ile Pro 
385                 390                 395                 400 


Pro Thr Arg Glu Val Pro Arg Lys Pro Gln Val Leu Pro His Ser His 
                405                 410                 415     


Val Glu Glu Asp Thr Asp Pro Asn Ser Val His Ser Ile Pro Arg Ser 
            420                 425                 430         


Ser Pro Glu Gly Ser Thr Lys Asp Leu Ile Glu Thr Cys Cys Ala Ala 
        435                 440                 445             


Gly Gln Gln Trp Ala Ile Asp Asn Asp Glu Cys Leu Glu Ile Pro Glu 
    450                 455                 460                 


Ser Gly Thr Glu Asp Asn Val Cys Arg Thr Ala Gln Arg His Cys Cys 
465                 470                 475                 480 


Val Ser Tyr Leu Gln Glu Lys Ser Cys Met Ala Gly Val Leu Gly Ala 
                485                 490                 495     


Lys Glu Gly Glu Thr Cys Gly Ala Glu Asp Asn Asp Ser Cys Gly Ile 
            500                 505                 510         


Ser Leu Tyr Lys Gln Cys Cys Asp Cys Cys Gly Leu Gly Leu Arg Val 
        515                 520                 525             


Arg Ala Glu Gly Gln Ser Cys Glu Ser Asn Pro Asn Leu Gly Tyr Pro 
    530                 535                 540                 


Cys Asn His Val Met Leu Ser Cys Cys Glu Gly Glu Glu Pro Leu Ile 
545                 550                 555                 560 


Val Pro Glu Val Arg Arg Pro Pro Glu Pro Ala Ala Ala Pro Arg Arg 
                565                 570                 575     


Val Ser Glu Ala Glu Met Ala Gly Arg Glu Ala Leu Ser Leu Gly Thr 
            580                 585                 590         


Glu Ala Glu Leu Pro Asn Ser Leu Pro Gly Asp Asp Gln Asp Glu Cys 
        595                 600                 605             


Leu Leu Leu Pro Gly Glu Leu Cys Gln His Leu Cys Ile Asn Thr Val 
    610                 615                 620                 


Gly Ser Tyr His Cys Ala Cys Phe Pro Gly Phe Ser Leu Gln Asp Asp 
625                 630                 635                 640 


Gly Arg Thr Cys Arg Pro Glu Gly His Pro Pro Gln Pro Glu Ala Pro 
                645                 650                 655     


Gln Glu Pro Ala Leu Lys Ser Glu Phe Ser Gln Val Ala Ser Asn Thr 
            660                 665                 670         


Ile Pro Leu Pro Leu Pro Gln Pro Asn Thr Cys Lys Asp Asn Gly Pro 
        675                 680                 685             


Cys Lys Gln Val Cys Ser Thr Val Gly Gly Ser Ala Ile Cys Ser Cys 
    690                 695                 700                 


Phe Pro Gly Tyr Ala Ile Met Ala Asp Gly Val Ser Cys Glu Asp Gln 
705                 710                 715                 720 


Asp Glu Cys Leu Met Gly Ala His Asp Cys Ser Arg Arg Gln Phe Cys 
                725                 730                 735     


Val Asn Thr Leu Gly Ser Phe Tyr Cys Val Asn His Thr Val Leu Cys 
            740                 745                 750         


Ala Asp Gly Tyr Ile Leu Asn Ala His Arg Lys Cys Val Asp Ile Asn 
        755                 760                 765             


Glu Cys Val Thr Asp Leu His Thr Cys Ser Arg Gly Glu His Cys Val 
    770                 775                 780                 


Asn Thr Leu Gly Ser Phe His Cys Tyr Lys Ala Leu Thr Cys Glu Pro 
785                 790                 795                 800 


Gly Tyr Ala Leu Lys Asp Gly Glu Cys Glu Asp Val Asp Glu Cys Ala 
                805                 810                 815     


Met Gly Thr His Thr Cys Gln Pro Gly Phe Leu Cys Gln Asn Thr Lys 
            820                 825                 830         


Gly Ser Phe Tyr Cys Gln Ala Arg Gln Arg Cys Met Asp Gly Phe Leu 
        835                 840                 845             


Gln Asp Pro Glu Gly Asn Cys Val Asp Ile Asn Glu Cys Thr Ser Leu 
    850                 855                 860                 


Ser Glu Pro Cys Arg Pro Gly Phe Ser Cys Ile Asn Thr Val Gly Ser 
865                 870                 875                 880 


Tyr Thr Cys Gln Arg Asn Pro Leu Ile Cys Ala Arg Gly Tyr His Ala 
                885                 890                 895     


Ser Asp Asp Gly Thr Lys Cys Val Asp Val Asn Glu Cys Glu Thr Gly 
            900                 905                 910         


Val His Arg Cys Gly Glu Gly Gln Val Cys His Asn Leu Pro Gly Ser 
        915                 920                 925             


Tyr Arg Cys Asp Cys Lys Ala Gly Phe Gln Arg Asp Ala Phe Gly Arg 
    930                 935                 940                 


Gly Cys Ile Asp Val Asn Glu Cys Trp Ala Ser Pro Gly Arg Leu Cys 
945                 950                 955                 960 


Gln His Thr Cys Glu Asn Thr Leu Gly Ser Tyr Arg Cys Ser Cys Ala 
                965                 970                 975     


Ser Gly Phe Leu Leu Ala Ala Asp Gly Lys Arg Cys Glu Asp Val Asn 
            980                 985                 990         


Glu Cys Glu Ala Gln Arg Cys Ser  Gln Glu Cys Ala Asn  Ile Tyr Gly 
        995                 1000                 1005             


Ser Tyr  Gln Cys Tyr Cys Arg  Gln Gly Tyr Gln Leu  Ala Glu Asp 
    1010                 1015                 1020             


Gly His  Thr Cys Thr Asp Ile  Asp Glu Cys Ala Gln  Gly Ala Gly 
    1025                 1030                 1035             


Ile Leu  Cys Thr Phe Arg Cys  Leu Asn Val Pro Gly  Ser Tyr Gln 
    1040                 1045                 1050             


Cys Ala  Cys Pro Glu Gln Gly  Tyr Thr Met Thr Ala  Asn Gly Arg 
    1055                 1060                 1065             


Ser Cys  Lys Asp Val Asp Glu  Cys Ala Leu Gly Thr  His Asn Cys 
    1070                 1075                 1080             


Ser Glu  Ala Glu Thr Cys His  Asn Ile Gln Gly Ser  Phe Arg Cys 
    1085                 1090                 1095             


Leu Arg  Phe Glu Cys Pro Pro  Asn Tyr Val Gln Val  Ser Lys Thr 
    1100                 1105                 1110             


Lys Cys  Glu Arg Thr Thr Cys  His Asp Phe Leu Glu  Cys Gln Asn 
    1115                 1120                 1125             


Ser Pro  Ala Arg Ile Thr His  Tyr Gln Leu Asn Phe  Gln Thr Gly 
    1130                 1135                 1140             


Leu Leu  Val Pro Ala His Ile  Phe Arg Ile Gly Pro  Ala Pro Ala 
    1145                 1150                 1155             


Phe Thr  Gly Asp Thr Ile Ala  Leu Asn Ile Ile Lys  Gly Asn Glu 
    1160                 1165                 1170             


Glu Gly  Tyr Phe Gly Thr Arg  Arg Leu Asn Ala Tyr  Thr Gly Val 
    1175                 1180                 1185             


Val Tyr  Leu Gln Arg Ala Val  Leu Glu Pro Arg Asp  Phe Ala Leu 
    1190                 1195                 1200             


Asp Val  Glu Met Lys Leu Trp  Arg Gln Gly Ser Val  Thr Thr Phe 
    1205                 1210                 1215             


Leu Ala  Lys Met His Ile Phe  Phe Thr Thr Phe Ala  Leu 
    1220                 1225                 1230     


<210>  5138
<211>  109
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5138

Xaa Ile Asp Glu Cys Ala Gln Gly Ala Gly Ile Leu Cys Thr Phe Arg 
1               5                   10                  15      


Cys Leu Asn Val Pro Gly Ser Tyr Gln Cys Ala Cys Pro Glu Gln Gly 
            20                  25                  30          


Tyr Thr Met Thr Ala Asn Gly Arg Ser Cys Lys Asp Val Asp Glu Cys 
        35                  40                  45              


Ala Leu Gly Thr His Asn Cys Ser Glu Ala Glu Thr Cys His Asn Ile 
    50                  55                  60                  


Gln Gly Ser Phe Arg Cys Leu Arg Phe Glu Cys Pro Pro Asn Tyr Val 
65                  70                  75                  80  


Gln Val Ser Lys Thr Trp Cys Val Pro Thr Gln Ala Pro Ser Gly Ser 
                85                  90                  95      


Leu His Gly Gly Pro Arg Pro Trp Arg Val Pro Cys Gly 
            100                 105                 


<210>  5139
<211>  101
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5139

Xaa Val Asp Glu Cys Ala Leu Gly Thr His Asn Cys Ser Glu Ala Glu 
1               5                   10                  15      


Thr Cys His Asn Ile Gln Gly Ser Phe Arg Cys Leu Arg Phe Glu Cys 
            20                  25                  30          


Pro Pro Asn Tyr Val Gln Val Ser Lys Thr Lys Cys Glu Arg Thr Lys 
        35                  40                  45              


Trp Lys Leu Ala Arg Trp Ala Thr Ala Val Ala Gly Ala Leu Trp Val 
    50                  55                  60                  


Arg Leu Gly Asp Asp Leu Arg Thr Arg Asp Thr Arg Pro Cys Trp Gly 
65                  70                  75                  80  


Ser Trp Thr Pro Leu Asp Asp Pro Ser Pro Lys Leu Thr Phe His Phe 
                85                  90                  95      


Met Phe His Cys Asp 
            100     


<210>  5140
<211>  44
<212>  PRT
<213>  Homo Sapiens

<400>  5140

Met Pro Gly Ile Lys Arg Ile Leu Thr Val Thr Ile Leu Ala Leu Cys 
1               5                   10                  15      


Leu Pro Ser Pro Gly Asn Ala Gln Ala Gln Cys Thr Asn Gly Phe Asp 
            20                  25                  30          


Leu Asp Arg Gln Ser Gly Gln Cys Leu Ala Ser Leu 
        35                  40                  


<210>  5141
<211>  489
<212>  PRT
<213>  Homo Sapiens

<400>  5141

Met Pro Gly Ile Lys Arg Ile Leu Thr Val Thr Ile Leu Ala Leu Cys 
1               5                   10                  15      


Leu Pro Ser Pro Gly Asn Ala Gln Ala Gln Cys Thr Asn Gly Phe Asp 
            20                  25                  30          


Leu Asp Arg Gln Ser Gly Gln Cys Leu Asp Gly Val Ser Leu Ser Ser 
        35                  40                  45              


Pro Arg Leu Glu Cys Asn Gly Ala Ile Ser Ala His Cys Asn Leu Cys 
    50                  55                  60                  


Leu Pro Gly Ser Ser Asp Ser Ser Ala Ser Ala Ser Gln Val Ala Gly 
65                  70                  75                  80  


Ile Thr Asp Ile Asp Glu Cys Arg Thr Ile Pro Glu Ala Cys Arg Gly 
                85                  90                  95      


Asp Met Met Cys Val Asn Gln Asn Gly Gly Tyr Leu Cys Ile Pro Arg 
            100                 105                 110         


Thr Asn Pro Val Tyr Arg Gly Pro Tyr Ser Asn Pro Tyr Ser Thr Pro 
        115                 120                 125             


Tyr Ser Gly Pro Tyr Pro Ala Ala Ala Pro Pro Leu Ser Ala Pro Asn 
    130                 135                 140                 


Tyr Pro Thr Ile Ser Arg Pro Leu Ile Cys Arg Phe Gly Tyr Gln Met 
145                 150                 155                 160 


Asp Glu Ser Asn Gln Cys Val Asp Val Asp Glu Cys Ala Thr Asp Ser 
                165                 170                 175     


His Gln Cys Asn Pro Thr Gln Ile Cys Ile Asn Thr Glu Gly Gly Tyr 
            180                 185                 190         


Thr Cys Ser Cys Thr Asp Gly Tyr Trp Leu Leu Glu Gly Gln Cys Leu 
        195                 200                 205             


Asp Ile Asp Glu Cys Arg Tyr Gly Tyr Cys Gln Gln Leu Cys Ala Asn 
    210                 215                 220                 


Val Pro Gly Ser Tyr Ser Cys Thr Cys Asn Pro Gly Phe Thr Leu Asn 
225                 230                 235                 240 


Glu Asp Gly Arg Ser Cys Gln Asp Val Asn Glu Cys Ala Thr Glu Asn 
                245                 250                 255     


Pro Cys Val Gln Thr Cys Val Asn Thr Tyr Gly Ser Phe Ile Cys Arg 
            260                 265                 270         


Cys Asp Pro Gly Tyr Glu Leu Glu Glu Asp Gly Val His Cys Ser Asp 
        275                 280                 285             


Met Asp Glu Cys Ser Phe Ser Glu Phe Leu Cys Gln His Glu Cys Val 
    290                 295                 300                 


Asn Gln Pro Gly Thr Tyr Phe Cys Ser Cys Pro Pro Gly Tyr Ile Leu 
305                 310                 315                 320 


Leu Asp Asp Asn Arg Ser Cys Gln Asp Ile Asn Glu Cys Glu His Arg 
                325                 330                 335     


Asn His Thr Cys Asn Leu Gln Gln Thr Cys Tyr Asn Leu Gln Gly Gly 
            340                 345                 350         


Phe Lys Cys Ile Asp Pro Ile Arg Cys Glu Glu Pro Tyr Leu Arg Ile 
        355                 360                 365             


Ser Asp Asn Arg Cys Met Cys Pro Ala Glu Asn Pro Gly Cys Arg Asp 
    370                 375                 380                 


Gln Pro Phe Thr Ile Leu Tyr Arg Asp Met Asp Val Val Ser Gly Arg 
385                 390                 395                 400 


Ser Val Pro Ala Asp Ile Phe Gln Met Gln Ala Thr Thr Arg Tyr Pro 
                405                 410                 415     


Gly Ala Tyr Tyr Ile Phe Gln Ile Lys Ser Gly Asn Glu Gly Arg Glu 
            420                 425                 430         


Phe Tyr Met Arg Gln Thr Gly Pro Ile Ser Ala Thr Leu Val Met Thr 
        435                 440                 445             


Arg Pro Ile Lys Gly Pro Arg Glu Ile Gln Leu Asp Leu Glu Met Ile 
    450                 455                 460                 


Thr Val Asn Thr Val Ile Asn Phe Arg Gly Ser Ser Val Ile Arg Leu 
465                 470                 475                 480 


Arg Ile Tyr Val Ser Gln Tyr Pro Phe 
                485                 


<210>  5142
<211>  91
<212>  PRT
<213>  Homo Sapiens

<400>  5142

Met Pro Gly Ile Lys Arg Ile Leu Thr Val Thr Ile Leu Ala Leu Cys 
1               5                   10                  15      


Leu Pro Ser Pro Gly Asn Ala Gln Ala Gln Cys Thr Asn Gly Phe Asp 
            20                  25                  30          


Leu Asp Arg Gln Ser Gly Gln Cys Leu Asp Ile Asp Glu Cys Arg Thr 
        35                  40                  45              


Ile Pro Glu Ala Cys Arg Gly Asp Met Met Cys Val Asn Gln Asn Gly 
    50                  55                  60                  


Gly Tyr Leu Cys Ile Pro Arg Thr Asn Pro Val Tyr Arg Gly Pro Tyr 
65                  70                  75                  80  


Ser Asn Pro Tyr Ser Thr Pro Tyr Ser Gly Pro 
                85                  90      


<210>  5143
<211>  448
<212>  PRT
<213>  Homo Sapiens

<400>  5143

Met Pro Gly Ile Lys Arg Ile Leu Thr Val Thr Ile Leu Ala Leu Cys 
1               5                   10                  15      


Leu Pro Ser Pro Gly Asn Ala Gln Ala Gln Cys Thr Asn Gly Phe Asp 
            20                  25                  30          


Leu Asp Arg Gln Ser Gly Gln Cys Leu Asp Ile Asp Glu Cys Arg Thr 
        35                  40                  45              


Ile Pro Glu Ala Cys Arg Gly Asp Met Met Cys Val Asn Gln Asn Gly 
    50                  55                  60                  


Gly Tyr Leu Cys Ile Pro Arg Thr Asn Pro Val Tyr Arg Gly Pro Tyr 
65                  70                  75                  80  


Ser Asn Pro Tyr Ser Thr Pro Tyr Ser Gly Pro Tyr Pro Ala Ala Ala 
                85                  90                  95      


Pro Pro Leu Ser Ala Pro Asn Tyr Pro Thr Ile Ser Arg Pro Leu Ile 
            100                 105                 110         


Cys Arg Phe Gly Tyr Gln Met Asp Glu Ser Asn Gln Cys Val Asp Val 
        115                 120                 125             


Asp Glu Cys Ala Thr Asp Ser His Gln Cys Asn Pro Thr Gln Ile Cys 
    130                 135                 140                 


Ile Asn Thr Glu Gly Gly Tyr Thr Cys Ser Cys Thr Asp Gly Tyr Trp 
145                 150                 155                 160 


Leu Leu Glu Gly Gln Cys Leu Asp Ile Asp Glu Cys Arg Tyr Gly Tyr 
                165                 170                 175     


Cys Gln Gln Leu Cys Ala Asn Val Pro Gly Ser Tyr Ser Cys Thr Cys 
            180                 185                 190         


Asn Pro Gly Phe Thr Leu Asn Glu Asp Gly Arg Ser Cys Gln Asp Val 
        195                 200                 205             


Asn Glu Cys Ala Thr Glu Asn Pro Cys Val Gln Thr Cys Val Asn Thr 
    210                 215                 220                 


Tyr Gly Ser Phe Ile Cys Arg Cys Asp Pro Gly Tyr Glu Leu Glu Glu 
225                 230                 235                 240 


Asp Gly Val His Cys Ser Asp Met Asp Glu Cys Ser Phe Ser Glu Phe 
                245                 250                 255     


Leu Cys Gln His Glu Cys Val Asn Gln Pro Gly Thr Tyr Phe Cys Ser 
            260                 265                 270         


Cys Pro Pro Gly Tyr Ile Leu Leu Asp Asp Asn Arg Ser Cys Gln Asp 
        275                 280                 285             


Ile Asn Glu Cys Glu His Arg Asn His Thr Cys Asn Leu Gln Gln Thr 
    290                 295                 300                 


Cys Tyr Asn Leu Gln Gly Gly Phe Lys Cys Ile Asp Pro Ile Arg Cys 
305                 310                 315                 320 


Glu Glu Pro Tyr Leu Arg Ile Ser Asp Asn Arg Cys Met Cys Pro Ala 
                325                 330                 335     


Glu Asn Pro Gly Cys Arg Asp Gln Pro Phe Thr Ile Leu Tyr Arg Asp 
            340                 345                 350         


Met Asp Val Val Ser Gly Arg Ser Val Pro Ala Asp Ile Phe Gln Met 
        355                 360                 365             


Gln Ala Thr Thr Arg Tyr Pro Gly Ala Tyr Tyr Ile Phe Gln Ile Lys 
    370                 375                 380                 


Ser Gly Asn Glu Gly Arg Glu Phe Tyr Met Arg Gln Thr Gly Pro Ile 
385                 390                 395                 400 


Ser Ala Thr Leu Val Met Thr Arg Pro Ile Lys Gly Pro Arg Glu Ile 
                405                 410                 415     


Gln Leu Asp Leu Glu Met Ile Thr Val Asn Thr Val Ile Asn Phe Arg 
            420                 425                 430         


Gly Ser Ser Val Ile Arg Leu Arg Ile Tyr Val Ser Gln Tyr Pro Phe 
        435                 440                 445             


<210>  5144
<211>  35
<212>  PRT
<213>  Homo Sapiens

<400>  5144

Met Pro Gly Ile Lys Arg Ile Leu Thr Val Thr Ile Leu Ala Leu Cys 
1               5                   10                  15      


Leu Pro Ser Pro Gly Asn Ala Gln Gln Gln Glu Arg Trp Thr Pro Val 
            20                  25                  30          


Cys Gln Pro 
        35  


<210>  5145
<211>  453
<212>  PRT
<213>  Homo Sapiens

<400>  5145

Met Arg Ser Gly Asn Cys Arg Gln Arg Tyr Met Ile Leu Thr Val Thr 
1               5                   10                  15      


Ile Leu Ala Leu Cys Leu Pro Ser Pro Gly Asn Ala Gln Ala Gln Cys 
            20                  25                  30          


Thr Asn Gly Phe Asp Leu Asp Arg Gln Ser Gly Gln Cys Leu Asp Ile 
        35                  40                  45              


Asp Glu Cys Arg Thr Ile Pro Glu Ala Cys Arg Gly Asp Met Met Cys 
    50                  55                  60                  


Val Asn Gln Asn Gly Gly Tyr Leu Cys Ile Pro Arg Thr Asn Pro Val 
65                  70                  75                  80  


Tyr Arg Gly Pro Tyr Ser Asn Pro Tyr Ser Thr Pro Tyr Ser Gly Pro 
                85                  90                  95      


Tyr Pro Ala Ala Ala Pro Pro Leu Ser Ala Pro Asn Tyr Pro Thr Ile 
            100                 105                 110         


Ser Arg Pro Leu Ile Cys Arg Phe Gly Tyr Gln Met Asp Glu Ser Asn 
        115                 120                 125             


Gln Cys Val Asp Val Asp Glu Cys Ala Thr Asp Ser His Gln Cys Asn 
    130                 135                 140                 


Pro Thr Gln Ile Cys Ile Asn Thr Glu Gly Gly Tyr Thr Cys Ser Cys 
145                 150                 155                 160 


Thr Asp Gly Tyr Trp Leu Leu Glu Gly Gln Cys Leu Asp Ile Asp Glu 
                165                 170                 175     


Cys Arg Tyr Gly Tyr Cys Gln Gln Leu Cys Ala Asn Val Pro Gly Ser 
            180                 185                 190         


Tyr Ser Cys Thr Cys Asn Pro Gly Phe Thr Leu Asn Glu Asp Gly Arg 
        195                 200                 205             


Ser Cys Gln Asp Val Asn Glu Cys Ala Thr Glu Asn Pro Cys Val Gln 
    210                 215                 220                 


Thr Cys Val Asn Thr Tyr Gly Ser Phe Ile Cys Arg Cys Asp Pro Gly 
225                 230                 235                 240 


Tyr Glu Leu Glu Glu Asp Gly Val His Cys Ser Asp Met Asp Glu Cys 
                245                 250                 255     


Ser Phe Ser Glu Phe Leu Cys Gln His Glu Cys Val Asn Gln Pro Gly 
            260                 265                 270         


Thr Tyr Phe Cys Ser Cys Pro Pro Gly Tyr Ile Leu Leu Asp Asp Asn 
        275                 280                 285             


Arg Ser Cys Gln Asp Ile Asn Glu Cys Glu His Arg Asn His Thr Cys 
    290                 295                 300                 


Asn Leu Gln Gln Thr Cys Tyr Asn Leu Gln Gly Gly Phe Lys Cys Ile 
305                 310                 315                 320 


Asp Pro Ile Arg Cys Glu Glu Pro Tyr Leu Arg Ile Ser Asp Asn Arg 
                325                 330                 335     


Cys Met Cys Pro Ala Glu Asn Pro Gly Cys Arg Asp Gln Pro Phe Thr 
            340                 345                 350         


Ile Leu Tyr Arg Asp Met Asp Val Val Ser Gly Arg Ser Val Pro Ala 
        355                 360                 365             


Asp Ile Phe Gln Met Gln Ala Thr Thr Arg Tyr Pro Gly Ala Tyr Tyr 
    370                 375                 380                 


Ile Phe Gln Ile Lys Ser Gly Asn Glu Gly Arg Glu Phe Tyr Met Arg 
385                 390                 395                 400 


Gln Thr Gly Pro Ile Ser Ala Thr Leu Val Met Thr Arg Pro Ile Lys 
                405                 410                 415     


Gly Pro Arg Glu Ile Gln Leu Asp Leu Glu Met Ile Thr Val Asn Thr 
            420                 425                 430         


Val Ile Asn Phe Arg Gly Ser Ser Val Ile Arg Leu Arg Ile Tyr Val 
        435                 440                 445             


Ser Gln Tyr Pro Phe 
    450             


<210>  5146
<211>  261
<212>  PRT
<213>  Homo Sapiens

<400>  5146

Ala Gly Ser Ala Arg Thr Leu Gly Thr Ala Arg Gly Gly His Gly Ala 
1               5                   10                  15      


Gly Lys Gly Leu Ser Pro Thr Ala Leu Leu Pro Ala Arg Val Ala Ser 
            20                  25                  30          


Cys Ala Arg Ser Gln Lys Ala Trp Pro Leu Cys Ile Ile Asp Val Asn 
        35                  40                  45              


Glu Cys Glu Leu Tyr Gly Gln Glu Gly Arg Pro Arg Leu Cys Met His 
    50                  55                  60                  


Ala Cys Val Asn Thr Pro Gly Ser Tyr Arg Cys Thr Cys Pro Gly Gly 
65                  70                  75                  80  


Tyr Arg Thr Leu Ala Asp Gly Lys Ser Cys Glu Asp Val Asp Glu Cys 
                85                  90                  95      


Val Gly Leu Gln Pro Val Cys Pro Gln Gly Thr Thr Cys Ile Asn Thr 
            100                 105                 110         


Gly Gly Ser Phe Gln Cys Val Ser Pro Glu Cys Pro Glu Gly Ser Gly 
        115                 120                 125             


Asn Val Ser Tyr Val Lys Thr Ser Pro Phe Gln Cys Glu Arg Asn Pro 
    130                 135                 140                 


Cys Pro Met Asp Ser Arg Pro Cys Arg His Leu Pro Lys Thr Ile Ser 
145                 150                 155                 160 


Phe His Tyr Leu Ser Leu Pro Ser Asn Leu Lys Thr Pro Ile Thr Leu 
                165                 170                 175     


Phe Arg Met Ala Thr Ala Ser Ala Pro Gly Arg Ala Gly Pro Asn Ser 
            180                 185                 190         


Leu Arg Phe Gly Ile Val Gly Gly Asn Ser Arg Gly His Phe Val Met 
        195                 200                 205             


Gln Arg Ser Asp Arg Gln Thr Gly Asp Leu Ile Leu Val Gln Asn Leu 
    210                 215                 220                 


Glu Gly Pro Gln Thr Leu Glu Val Asp Val Asp Met Ser Glu Tyr Leu 
225                 230                 235                 240 


Asp Arg Ser Phe Gln Ala Asn His Val Ser Lys Val Thr Ile Phe Val 
                245                 250                 255     


Ser Pro Tyr Asp Phe 
            260     


<210>  5147
<211>  305
<212>  PRT
<213>  Homo Sapiens

<400>  5147

Met Val Pro Ser Ser Pro Arg Ala Leu Phe Leu Leu Leu Leu Ile Leu 
1               5                   10                  15      


Ala Cys Pro Glu Pro Arg Ala Ser Gln Asn Cys Leu Ser Lys Gln Gln 
            20                  25                  30          


Leu Leu Ser Ala Ile Arg Gln Leu Gln Gln Leu Leu Lys Gly Gln Glu 
        35                  40                  45              


Thr Arg Phe Ala Glu Gly Ile Arg His Met Lys Ser Arg Leu Ala Ala 
    50                  55                  60                  


Leu Gln Asn Ser Val Gly Arg Val Gly Pro Asp Ala Leu Pro Val Ser 
65                  70                  75                  80  


Cys Pro Ala Leu Asn Thr Pro Ala Asp Gly Arg Lys Phe Gly Ser Lys 
                85                  90                  95      


Tyr Leu Val Asp His Glu Val His Phe Thr Cys Asn Pro Gly Phe Arg 
            100                 105                 110         


Leu Val Gly Pro Ser Ser Val Val Cys Leu Pro Asn Gly Thr Trp Thr 
        115                 120                 125             


Gly Glu Gln Pro His Cys Arg Asp Val Asp Glu Cys Val Gly Leu Gln 
    130                 135                 140                 


Pro Val Cys Pro Gln Gly Thr Thr Cys Ile Asn Thr Gly Gly Ser Phe 
145                 150                 155                 160 


Gln Cys Val Ser Pro Glu Cys Pro Glu Gly Ser Gly Asn Val Ser Tyr 
                165                 170                 175     


Val Lys Thr Ser Pro Phe Gln Cys Glu Arg Asn Pro Cys Pro Met Asp 
            180                 185                 190         


Ser Arg Pro Cys Arg His Leu Pro Lys Thr Ile Ser Phe His Tyr Leu 
        195                 200                 205             


Ser Leu Pro Ser Asn Leu Lys Thr Pro Ile Thr Leu Phe Arg Met Ala 
    210                 215                 220                 


Thr Ala Ser Ala Pro Gly Arg Ala Gly Pro Asn Ser Leu Arg Phe Gly 
225                 230                 235                 240 


Ile Val Gly Gly Asn Ser Arg Gly His Phe Val Met Gln Arg Ser Asp 
                245                 250                 255     


Arg Gln Thr Gly Asp Leu Ile Leu Val Gln Asn Leu Glu Gly Pro Gln 
            260                 265                 270         


Thr Leu Glu Val Asp Val Asp Met Ser Glu Tyr Leu Asp Arg Ser Phe 
        275                 280                 285             


Gln Ala Asn His Val Ser Lys Val Thr Ile Phe Val Ser Pro Tyr Asp 
    290                 295                 300                 


Phe 
305 


<210>  5148
<211>  439
<212>  PRT
<213>  Homo Sapiens

<400>  5148

Met Val Pro Ser Ser Pro Arg Ala Leu Phe Leu Leu Leu Leu Ile Leu 
1               5                   10                  15      


Ala Cys Pro Glu Pro Arg Ala Ser Gln Asn Cys Leu Ser Lys Gln Gln 
            20                  25                  30          


Leu Leu Ser Ala Ile Arg Gln Leu Gln Gln Leu Leu Lys Gly Gln Glu 
        35                  40                  45              


Thr Arg Phe Ala Glu Gly Ile Arg His Met Lys Ser Arg Leu Ala Ala 
    50                  55                  60                  


Leu Gln Asn Ser Val Gly Arg Val Gly Pro Asp Ala Leu Pro Val Ser 
65                  70                  75                  80  


Cys Pro Ala Leu Asn Thr Pro Ala Asp Gly Arg Lys Phe Gly Ser Lys 
                85                  90                  95      


Tyr Leu Val Asp His Glu Val His Phe Thr Cys Asn Pro Gly Phe Arg 
            100                 105                 110         


Leu Val Gly Pro Ser Ser Val Val Cys Leu Pro Asn Gly Thr Trp Thr 
        115                 120                 125             


Gly Glu Gln Pro His Cys Arg Gly Ile Ser Glu Cys Ser Ser Gln Pro 
    130                 135                 140                 


Cys Gln Asn Gly Gly Thr Cys Val Glu Gly Val Asn Gln Tyr Arg Cys 
145                 150                 155                 160 


Ile Cys Pro Pro Gly Arg Thr Gly Asn Arg Cys Gln His Gln Ala Gln 
                165                 170                 175     


Thr Ala Ala Pro Glu Gly Ser Val Ala Gly Asp Ser Ala Phe Ser Arg 
            180                 185                 190         


Ala Pro Arg Cys Ala Gln Val Glu Arg Ala Gln His Cys Ser Cys Glu 
        195                 200                 205             


Ala Gly Phe His Leu Ser Gly Ala Ala Gly Asp Ser Val Cys Gln Asp 
    210                 215                 220                 


Val Asn Glu Cys Glu Leu Tyr Gly Gln Glu Gly Arg Pro Arg Leu Cys 
225                 230                 235                 240 


Met His Ala Cys Val Asn Thr Pro Gly Ser Tyr Arg Cys Thr Cys Pro 
                245                 250                 255     


Gly Gly Tyr Arg Thr Leu Ala Asp Gly Lys Ser Cys Glu Asp Val Asp 
            260                 265                 270         


Glu Cys Val Gly Leu Gln Pro Val Cys Pro Gln Gly Thr Thr Cys Ile 
        275                 280                 285             


Asn Thr Gly Gly Ser Phe Gln Cys Val Ser Pro Glu Cys Pro Glu Gly 
    290                 295                 300                 


Ser Gly Asn Val Ser Tyr Val Lys Thr Ser Pro Phe Gln Cys Glu Arg 
305                 310                 315                 320 


Asn Pro Cys Pro Met Asp Ser Arg Pro Cys Arg His Leu Pro Lys Thr 
                325                 330                 335     


Ile Ser Phe His Tyr Leu Ser Leu Pro Ser Asn Leu Lys Thr Pro Ile 
            340                 345                 350         


Thr Leu Phe Arg Met Ala Thr Ala Ser Ala Pro Gly Arg Ala Gly Pro 
        355                 360                 365             


Asn Ser Leu Arg Phe Gly Ile Val Gly Gly Asn Ser Arg Gly His Phe 
    370                 375                 380                 


Val Met Gln Arg Ser Asp Arg Gln Thr Gly Asp Leu Ile Leu Val Gln 
385                 390                 395                 400 


Asn Leu Glu Gly Pro Gln Thr Leu Glu Val Asp Val Asp Met Ser Glu 
                405                 410                 415     


Tyr Leu Asp Arg Ser Phe Gln Ala Asn His Val Ser Lys Val Thr Ile 
            420                 425                 430         


Phe Val Ser Pro Tyr Asp Phe 
        435                 


<210>  5149
<211>  366
<212>  PRT
<213>  Homo Sapiens

<400>  5149

Met Val Pro Ser Ser Pro Arg Ala Leu Phe Leu Leu Leu Leu Ile Leu 
1               5                   10                  15      


Ala Cys Pro Glu Pro Arg Ala Ser Gln Asn Cys Leu Ser Lys Gln Gln 
            20                  25                  30          


Leu Leu Ser Ala Ile Arg Gln Leu Gln Gln Leu Leu Lys Gly Gln Glu 
        35                  40                  45              


Thr Arg Phe Ala Glu Gly Ile Arg His Met Lys Ser Arg Leu Ala Ala 
    50                  55                  60                  


Leu Gln Asn Ser Val Gly Arg Val Gly Pro Asp Ala Leu Pro Val Ser 
65                  70                  75                  80  


Cys Pro Ala Leu Asn Thr Pro Ala Asp Gly Arg Lys Phe Gly Ser Lys 
                85                  90                  95      


Tyr Leu Val Asp His Glu Val His Phe Thr Cys Asn Pro Gly Phe Arg 
            100                 105                 110         


Leu Val Gly Pro Ser Ser Val Val Cys Leu Pro Asn Gly Thr Trp Thr 
        115                 120                 125             


Gly Glu Gln Pro His Cys Arg Gly Ile Ser Glu Cys Ser Ser Gln Pro 
    130                 135                 140                 


Cys Gln Asn Gly Gly Thr Cys Val Glu Gly Val Asn Gln Tyr Arg Cys 
145                 150                 155                 160 


Ile Cys Pro Pro Gly Arg Thr Gly Asn Arg Cys Gln His Gln Ala Gln 
                165                 170                 175     


Thr Ala Ala Pro Glu Gly Ser Val Ala Gly Asp Ser Ala Phe Ser Arg 
            180                 185                 190         


Ala Pro Arg Cys Ala Gln Val Glu Arg Ala Gln His Cys Ser Cys Glu 
        195                 200                 205             


Ala Gly Phe His Leu Ser Gly Ala Ala Gly Asp Ser Val Cys Gln Asp 
    210                 215                 220                 


Val Asn Glu Cys Glu Leu Tyr Gly Gln Glu Gly Arg Pro Arg Leu Cys 
225                 230                 235                 240 


Met His Ala Cys Val Asn Thr Pro Gly Ser Tyr Arg Cys Thr Cys Pro 
                245                 250                 255     


Gly Gly Tyr Arg Thr Leu Ala Asp Gly Lys Ser Cys Glu Asp Val Asp 
            260                 265                 270         


Glu Cys Val Gly Leu Gln Pro Val Cys Pro Gln Gly Thr Thr Cys Ile 
        275                 280                 285             


Asn Thr Gly Gly Ser Phe Gln Cys Val Ser Pro Glu Cys Pro Glu Gly 
    290                 295                 300                 


Ser Gly Asn Val Ser Tyr Val Lys Thr Ser Pro Leu Thr Trp Arg Gly 
305                 310                 315                 320 


Leu Arg Arg Trp Arg Trp Thr Ser Thr Cys Arg Asn Thr Trp Thr Ala 
                325                 330                 335     


Pro Ser Arg Pro Thr Thr Cys Pro Arg Ser Pro Ser Leu Tyr Pro Pro 
            340                 345                 350         


Met Thr Ser Glu Gly Thr Gln Gly His Trp Gly Val Glu Ser 
        355                 360                 365     


<210>  5150
<211>  393
<212>  PRT
<213>  Homo Sapiens

<400>  5150

Met Val Pro Ser Ser Pro Arg Ala Leu Phe Leu Leu Leu Leu Ile Leu 
1               5                   10                  15      


Ala Cys Pro Glu Pro Arg Ala Ser Gln Asn Cys Leu Ser Lys Gln Gln 
            20                  25                  30          


Leu Leu Ser Ala Ile Arg Gln Leu Gln Gln Leu Leu Lys Gly Gln Glu 
        35                  40                  45              


Thr Arg Phe Ala Glu Gly Ile Arg His Met Lys Ser Arg Leu Ala Ala 
    50                  55                  60                  


Leu Gln Asn Ser Val Gly Arg Val Gly Pro Asp Ala Leu Pro Val Ser 
65                  70                  75                  80  


Cys Pro Ala Leu Asn Thr Pro Ala Asp Gly Arg Lys Phe Gly Ser Lys 
                85                  90                  95      


Tyr Leu Val Asp His Glu Val His Phe Thr Cys Asn Pro Gly Phe Arg 
            100                 105                 110         


Leu Val Gly Pro Ser Ser Val Val Cys Leu Pro Asn Gly Thr Trp Thr 
        115                 120                 125             


Gly Glu Gln Pro His Cys Arg Gly Ile Ser Glu Cys Ser Ser Gln Pro 
    130                 135                 140                 


Cys Gln Asn Gly Gly Thr Cys Val Glu Gly Val Asn Gln Tyr Arg Cys 
145                 150                 155                 160 


Ile Cys Pro Pro Gly Arg Thr Gly Asn Arg Cys Gln His Gln Ala Gln 
                165                 170                 175     


Thr Asp Val Asn Glu Cys Glu Leu Tyr Gly Gln Glu Gly Arg Pro Arg 
            180                 185                 190         


Leu Cys Met His Ala Cys Val Asn Thr Pro Gly Ser Tyr Arg Cys Thr 
        195                 200                 205             


Cys Pro Gly Gly Tyr Arg Thr Leu Ala Asp Gly Lys Ser Cys Glu Asp 
    210                 215                 220                 


Val Asp Glu Cys Val Gly Leu Gln Pro Val Cys Pro Gln Gly Thr Thr 
225                 230                 235                 240 


Cys Ile Asn Thr Gly Gly Ser Phe Gln Cys Val Ser Pro Glu Cys Pro 
                245                 250                 255     


Glu Gly Ser Gly Asn Val Ser Tyr Val Lys Thr Ser Pro Phe Gln Cys 
            260                 265                 270         


Glu Arg Asn Pro Cys Pro Met Asp Ser Arg Pro Cys Arg His Leu Pro 
        275                 280                 285             


Lys Thr Ile Ser Phe His Tyr Leu Ser Leu Pro Ser Asn Leu Lys Thr 
    290                 295                 300                 


Pro Ile Thr Leu Phe Arg Met Ala Thr Ala Ser Ala Pro Gly Arg Ala 
305                 310                 315                 320 


Gly Pro Asn Ser Leu Arg Phe Gly Ile Val Gly Gly Asn Ser Arg Gly 
                325                 330                 335     


His Phe Val Met Gln Arg Ser Asp Arg Gln Thr Gly Asp Leu Ile Leu 
            340                 345                 350         


Val Gln Asn Leu Glu Gly Pro Gln Thr Leu Glu Val Asp Val Asp Met 
        355                 360                 365             


Ser Glu Tyr Leu Asp Arg Ser Phe Gln Ala Asn His Val Ser Lys Val 
    370                 375                 380                 


Thr Ile Phe Val Ser Pro Tyr Asp Phe 
385                 390             


<210>  5151
<211>  273
<212>  PRT
<213>  Homo Sapiens

<400>  5151

Arg Phe Ala Glu Gly Ile Arg His Met Lys Ser Arg Leu Ala Ala Leu 
1               5                   10                  15      


Gln Asn Ser Val Gly Arg Val Gly Pro Asp Ala Leu Pro Gly Ile Ser 
            20                  25                  30          


Glu Cys Ser Ser Gln Pro Cys Gln Asn Gly Gly Thr Cys Val Glu Gly 
        35                  40                  45              


Val Asn Gln Tyr Arg Cys Ile Cys Pro Pro Gly Arg Thr Gly Asn Arg 
    50                  55                  60                  


Cys Gln His Gln Ala Gln Thr Ala Ala Pro Glu Gly Ser Val Ala Gly 
65                  70                  75                  80  


Asp Ser Ala Phe Ser Arg Ala Pro Arg Cys Ala Gln Val Glu Arg Ala 
                85                  90                  95      


Gln His Cys Ser Cys Glu Ala Gly Phe His Leu Ser Gly Ala Ala Gly 
            100                 105                 110         


Asp Ser Val Cys Gln Asp Val Asn Glu Cys Glu Leu Tyr Gly Gln Glu 
        115                 120                 125             


Gly Arg Pro Arg Leu Cys Met His Ala Cys Val Asn Thr Pro Gly Ser 
    130                 135                 140                 


Tyr Arg Cys Thr Cys Pro Gly Gly Tyr Arg Thr Leu Ala Asp Gly Lys 
145                 150                 155                 160 


Ser Cys Glu Asp Val Asp Glu Cys Val Gly Leu Gln Pro Val Cys Pro 
                165                 170                 175     


Gln Gly Thr Thr Cys Ile Asn Thr Gly Gly Ser Phe Gln Cys Val Ser 
            180                 185                 190         


Pro Glu Cys Pro Glu Gly Ser Gly Asn Val Ser Tyr Val Lys Thr Ser 
        195                 200                 205             


Pro Phe Gln Cys Glu Arg Asn Pro Cys Pro Met Asp Ser Arg Pro Cys 
    210                 215                 220                 


Arg His Leu Pro Lys Thr Ile Ser Phe His Tyr Leu Ser Leu Pro Ser 
225                 230                 235                 240 


Asn Leu Lys Thr Pro Ile Thr Leu Phe Arg Met Ala Thr Ala Ser Ala 
                245                 250                 255     


Pro Gly Arg Ala Gly Pro Asn Ser Leu Arg Phe Gly Ile Val Gly Gly 
            260                 265                 270         


Asn 
    


<210>  5152
<211>  55
<212>  PRT
<213>  Homo Sapiens

<400>  5152

Met Arg Arg Gly Arg Leu Leu Glu Ile Ala Leu Gly Phe Thr Val Leu 
1               5                   10                  15      


Leu Ala Ser Tyr Thr Ser His Gly Ala Asp Ala Asn Leu Glu Ala Gly 
            20                  25                  30          


Asn Val Lys Glu Thr Arg Ala Ser Arg Ala Lys Arg Arg Gly Gly Gly 
        35                  40                  45              


Gly His Asp Ala Leu Lys Gly 
    50                  55  


<210>  5153
<211>  302
<212>  PRT
<213>  Homo Sapiens

<400>  5153

Met Arg Arg Gly Arg Leu Leu Glu Ile Ala Leu Gly Phe Thr Val Leu 
1               5                   10                  15      


Leu Ala Ser Tyr Thr Ser His Gly Ala Asp Ala Asn Leu Glu Ala Gly 
            20                  25                  30          


Asn Val Lys Glu Thr Arg Ala Ser Arg Ala Lys Arg Arg Gly Gly Gly 
        35                  40                  45              


Gly His Asp Ala Leu Lys Gly Pro Asn Val Cys Gly Ser Arg Tyr Asn 
    50                  55                  60                  


Ala Tyr Cys Cys Pro Gly Trp Lys Thr Leu Pro Gly Gly Asn Gln Cys 
65                  70                  75                  80  


Ile Val Pro Ile Cys Arg His Ser Cys Gly Asp Gly Phe Cys Ser Arg 
                85                  90                  95      


Pro Asn Met Cys Thr Cys Pro Ser Gly Gln Ile Ala Pro Ser Cys Gly 
            100                 105                 110         


Ser Arg Ser Ile Gln His Cys Asn Ile Arg Cys Met Asn Gly Gly Ser 
        115                 120                 125             


Cys Ser Asp Asp His Cys Leu Cys Gln Lys Gly Tyr Ile Gly Thr His 
    130                 135                 140                 


Cys Gly Gln Pro Val Cys Glu Ser Gly Cys Leu Asn Gly Gly Arg Cys 
145                 150                 155                 160 


Val Ala Pro Asn Arg Cys Ala Cys Thr Tyr Gly Phe Thr Gly Pro Gln 
                165                 170                 175     


Cys Glu Arg Asp Tyr Arg Thr Gly Pro Cys Phe Thr Val Ile Ser Asn 
            180                 185                 190         


Gln Met Cys Gln Gly Gln Leu Ser Gly Ile Val Cys Thr Lys Thr Leu 
        195                 200                 205             


Cys Cys Ala Thr Thr Ser Met Asn Val Lys Leu Glu His Thr Thr Val 
    210                 215                 220                 


Ala Asn Met Leu Tyr Val Pro Ile Gln Gln Glu Ala Ser Asn Val Ala 
225                 230                 235                 240 


Ala Val Pro Gly Gly Leu Glu Met Ala Leu Ser Ala Leu Ile Trp Thr 
                245                 250                 255     


Asn Val Pro Met Glu Pro Ile Cys Ala Ala Ser Met Gln Thr Ala Arg 
            260                 265                 270         


Ile Pro Trp Asp Leu Thr Ala Val Cys Ala Arg Lys Asp Thr Gln Val 
        275                 280                 285             


Met Ala Ser Leu Val Gln Thr Leu Met Ser Ala Leu Arg Thr 
    290                 295                 300         


<210>  5154
<211>  2871
<212>  PRT
<213>  Homo Sapiens

<400>  5154

Met Arg Arg Gly Arg Leu Leu Glu Ile Ala Leu Gly Phe Thr Val Leu 
1               5                   10                  15      


Leu Ala Ser Tyr Thr Ser His Gly Ala Asp Ala Asn Leu Glu Ala Gly 
            20                  25                  30          


Asn Val Lys Glu Thr Arg Ala Ser Arg Ala Lys Arg Arg Gly Gly Gly 
        35                  40                  45              


Gly His Asp Ala Leu Lys Gly Pro Asn Val Cys Gly Ser Arg Tyr Asn 
    50                  55                  60                  


Ala Tyr Cys Cys Pro Gly Trp Lys Thr Leu Pro Gly Gly Asn Gln Cys 
65                  70                  75                  80  


Ile Val Pro Ile Cys Arg His Ser Cys Gly Asp Gly Phe Cys Ser Arg 
                85                  90                  95      


Pro Asn Met Cys Thr Cys Pro Ser Gly Gln Ile Ala Pro Ser Cys Gly 
            100                 105                 110         


Ser Arg Ser Ile Gln His Cys Asn Ile Arg Cys Met Asn Gly Gly Ser 
        115                 120                 125             


Cys Ser Asp Asp His Cys Leu Cys Gln Lys Gly Tyr Ile Gly Thr His 
    130                 135                 140                 


Cys Gly Gln Pro Val Cys Glu Ser Gly Cys Leu Asn Gly Gly Arg Cys 
145                 150                 155                 160 


Val Ala Pro Asn Arg Cys Ala Cys Thr Tyr Gly Phe Thr Gly Pro Gln 
                165                 170                 175     


Cys Glu Arg Asp Tyr Arg Thr Gly Pro Cys Phe Thr Val Ile Ser Asn 
            180                 185                 190         


Gln Met Cys Gln Gly Gln Leu Ser Gly Ile Val Cys Thr Lys Thr Leu 
        195                 200                 205             


Cys Cys Ala Thr Val Gly Arg Ala Trp Gly His Pro Cys Glu Met Cys 
    210                 215                 220                 


Pro Ala Gln Pro His Pro Cys Arg Arg Gly Phe Ile Pro Asn Ile Arg 
225                 230                 235                 240 


Thr Gly Ala Cys Gln Asp Val Asp Glu Cys Gln Ala Ile Pro Gly Leu 
                245                 250                 255     


Cys Gln Gly Gly Asn Cys Ile Asn Thr Val Gly Ser Phe Glu Cys Lys 
            260                 265                 270         


Cys Pro Ala Gly His Lys Leu Asn Glu Val Ser Gln Lys Cys Glu Asp 
        275                 280                 285             


Ile Asp Glu Cys Ser Thr Ile Pro Gly Ile Cys Glu Gly Gly Glu Cys 
    290                 295                 300                 


Thr Asn Thr Val Ser Ser Tyr Phe Cys Lys Cys Pro Pro Gly Phe Tyr 
305                 310                 315                 320 


Thr Ser Pro Asp Gly Thr Arg Cys Ile Asp Val Arg Pro Gly Tyr Cys 
                325                 330                 335     


Tyr Thr Ala Leu Thr Asn Gly Arg Cys Ser Asn Gln Leu Pro Gln Ser 
            340                 345                 350         


Ile Thr Lys Met Gln Cys Cys Cys Asp Ala Gly Arg Cys Trp Ser Pro 
        355                 360                 365             


Gly Val Thr Val Ala Pro Glu Met Cys Pro Ile Arg Ala Thr Glu Asp 
    370                 375                 380                 


Phe Asn Lys Leu Cys Ser Val Pro Met Val Ile Pro Gly Arg Pro Glu 
385                 390                 395                 400 


Tyr Pro Pro Pro Pro Leu Gly Pro Ile Pro Pro Val Leu Pro Val Pro 
                405                 410                 415     


Pro Gly Phe Pro Pro Gly Pro Gln Ile Pro Val Pro Arg Pro Pro Val 
            420                 425                 430         


Glu Tyr Leu Tyr Pro Ser Arg Glu Pro Pro Arg Val Leu Pro Val Asn 
        435                 440                 445             


Val Thr Asp Tyr Cys Gln Leu Val Arg Tyr Leu Cys Gln Asn Gly Arg 
    450                 455                 460                 


Cys Ile Pro Thr Pro Gly Ser Tyr Arg Cys Glu Cys Asn Lys Gly Phe 
465                 470                 475                 480 


Gln Leu Asp Leu Arg Gly Glu Cys Ile Asp Val Asp Glu Cys Glu Lys 
                485                 490                 495     


Asn Pro Cys Ala Gly Gly Glu Cys Ile Asn Asn Gln Gly Ser Tyr Thr 
            500                 505                 510         


Cys Gln Cys Arg Ala Gly Tyr Gln Ser Thr Leu Thr Arg Thr Glu Cys 
        515                 520                 525             


Arg Asp Ile Asp Glu Cys Leu Gln Asn Gly Arg Ile Cys Asn Asn Gly 
    530                 535                 540                 


Arg Cys Ile Asn Thr Asp Gly Ser Phe His Cys Val Cys Asn Ala Gly 
545                 550                 555                 560 


Phe His Val Thr Arg Asp Gly Lys Asn Cys Glu Asp Met Asp Glu Cys 
                565                 570                 575     


Ser Ile Arg Asn Met Cys Leu Asn Gly Met Cys Ile Asn Glu Asp Gly 
            580                 585                 590         


Ser Phe Lys Cys Ile Cys Lys Pro Gly Phe Gln Leu Ala Ser Asp Gly 
        595                 600                 605             


Arg Tyr Cys Lys Asp Ile Asn Glu Cys Glu Thr Pro Gly Ile Cys Met 
    610                 615                 620                 


Asn Gly Arg Cys Val Asn Thr Asp Gly Ser Tyr Arg Cys Glu Cys Phe 
625                 630                 635                 640 


Pro Gly Leu Ala Val Gly Leu Asp Gly Arg Val Cys Val Asp Thr His 
                645                 650                 655     


Met Arg Ser Thr Cys Tyr Gly Gly Tyr Lys Arg Gly Gln Cys Ile Lys 
            660                 665                 670         


Pro Leu Phe Gly Ala Val Thr Lys Ser Glu Cys Cys Cys Ala Ser Thr 
        675                 680                 685             


Glu Tyr Ala Phe Gly Glu Pro Cys Gln Pro Cys Pro Ala Gln Asn Ser 
    690                 695                 700                 


Ala Glu Tyr Gln Ala Leu Cys Ser Ser Gly Pro Gly Met Thr Ser Ala 
705                 710                 715                 720 


Gly Ser Asp Ile Asn Glu Cys Ala Leu Asp Pro Asp Ile Cys Pro Asn 
                725                 730                 735     


Gly Ile Cys Glu Asn Leu Arg Gly Thr Tyr Lys Cys Ile Cys Asn Ser 
            740                 745                 750         


Gly Tyr Glu Val Asp Ser Thr Gly Lys Asn Cys Val Asp Ile Asn Glu 
        755                 760                 765             


Cys Val Leu Asn Ser Leu Leu Cys Asp Asn Gly Gln Cys Arg Asn Thr 
    770                 775                 780                 


Pro Gly Ser Phe Val Cys Thr Cys Pro Lys Gly Phe Ile Tyr Lys Pro 
785                 790                 795                 800 


Asp Leu Lys Thr Cys Glu Asp Ile Asp Glu Cys Glu Ser Ser Pro Cys 
                805                 810                 815     


Ile Asn Gly Val Cys Lys Asn Ser Pro Gly Ser Phe Ile Cys Glu Cys 
            820                 825                 830         


Ser Ser Glu Ser Thr Leu Asp Pro Thr Lys Thr Ile Cys Ile Glu Thr 
        835                 840                 845             


Ile Lys Gly Thr Cys Trp Gln Thr Val Ile Asp Gly Arg Cys Glu Ile 
    850                 855                 860                 


Asn Ile Asn Gly Ala Thr Leu Lys Ser Gln Cys Cys Ser Ser Leu Gly 
865                 870                 875                 880 


Ala Ala Trp Gly Ser Pro Cys Thr Leu Cys Gln Val Asp Pro Ile Cys 
                885                 890                 895     


Gly Lys Gly Tyr Ser Arg Ile Lys Gly Thr Gln Cys Glu Asp Ile Asp 
            900                 905                 910         


Glu Cys Glu Val Phe Pro Gly Val Cys Lys Asn Gly Leu Cys Val Asn 
        915                 920                 925             


Thr Arg Gly Ser Phe Lys Cys Gln Cys Pro Ser Gly Met Thr Leu Asp 
    930                 935                 940                 


Ala Thr Gly Arg Ile Cys Leu Asp Ile Arg Leu Glu Thr Cys Phe Leu 
945                 950                 955                 960 


Arg Tyr Glu Asp Glu Glu Cys Thr Leu Pro Ile Ala Gly Arg His Arg 
                965                 970                 975     


Met Asp Ala Cys Cys Cys Ser Val Gly Ala Ala Trp Gly Thr Glu Glu 
            980                 985                 990         


Cys Glu Glu Cys Pro Met Arg Asn  Thr Pro Glu Tyr Glu  Glu Leu Cys 
        995                 1000                 1005             


Pro Arg  Gly Pro Gly Phe Ala  Thr Lys Glu Ile Thr  Asn Gly Lys 
    1010                 1015                 1020             


Pro Phe  Phe Lys Asp Ile Asn  Glu Cys Lys Met Ile  Pro Ser Leu 
    1025                 1030                 1035             


Cys Thr  His Gly Lys Cys Arg  Asn Thr Ile Gly Ser  Phe Lys Cys 
    1040                 1045                 1050             


Arg Cys  Asp Ser Gly Phe Ala  Leu Asp Ser Glu Glu  Arg Asn Cys 
    1055                 1060                 1065             


Thr Asp  Ile Asp Glu Cys Arg  Ile Ser Pro Asp Leu  Cys Gly Arg 
    1070                 1075                 1080             


Gly Gln  Cys Val Asn Thr Pro  Gly Asp Phe Glu Cys  Lys Cys Asp 
    1085                 1090                 1095             


Glu Gly  Tyr Glu Ser Gly Phe  Met Met Met Lys Asn  Cys Met Asp 
    1100                 1105                 1110             


Ile Asp  Glu Cys Gln Arg Asp  Pro Leu Leu Cys Arg  Gly Gly Val 
    1115                 1120                 1125             


Cys His  Asn Thr Glu Gly Ser  Tyr Arg Cys Glu Cys  Pro Pro Gly 
    1130                 1135                 1140             


His Gln  Leu Ser Pro Asn Ile  Ser Ala Cys Ile Asp  Ile Asn Glu 
    1145                 1150                 1155             


Cys Glu  Leu Ser Ala His Leu  Cys Pro Asn Gly Arg  Cys Val Asn 
    1160                 1165                 1170             


Leu Ile  Gly Lys Tyr Gln Cys  Ala Cys Asn Pro Gly  Tyr His Ser 
    1175                 1180                 1185             


Thr Pro  Asp Arg Leu Phe Cys  Val Asp Ile Asp Glu  Cys Ser Ile 
    1190                 1195                 1200             


Met Asn  Gly Gly Cys Glu Thr  Phe Cys Thr Asn Ser  Glu Gly Ser 
    1205                 1210                 1215             


Tyr Glu  Cys Ser Cys Gln Pro  Gly Phe Ala Leu Met  Pro Asp Gln 
    1220                 1225                 1230             


Arg Ser  Cys Thr Asp Ile Asp  Glu Cys Glu Asp Asn  Pro Asn Ile 
    1235                 1240                 1245             


Cys Asp  Gly Gly Gln Cys Thr  Asn Ile Pro Gly Glu  Tyr Arg Cys 
    1250                 1255                 1260             


Leu Cys  Tyr Asp Gly Phe Met  Ala Ser Glu Asp Met  Lys Thr Cys 
    1265                 1270                 1275             


Val Asp  Val Asn Glu Cys Asp  Leu Asn Pro Asn Ile  Cys Leu Ser 
    1280                 1285                 1290             


Gly Thr  Cys Glu Asn Thr Lys  Gly Ser Phe Ile Cys  His Cys Asp 
    1295                 1300                 1305             


Met Gly  Tyr Ser Gly Lys Lys  Gly Lys Thr Gly Cys  Thr Asp Ile 
    1310                 1315                 1320             


Asn Glu  Cys Glu Ile Gly Ala  His Asn Cys Gly Lys  His Ala Val 
    1325                 1330                 1335             


Cys Thr  Asn Thr Ala Gly Ser  Phe Lys Cys Ser Cys  Ser Pro Gly 
    1340                 1345                 1350             


Trp Ile  Gly Asp Gly Ile Lys  Cys Thr Asp Leu Asp  Glu Cys Ser 
    1355                 1360                 1365             


Asn Gly  Thr His Met Cys Ser  Gln His Ala Asp Cys  Lys Asn Thr 
    1370                 1375                 1380             


Met Gly  Ser Tyr Arg Cys Leu  Cys Lys Glu Gly Tyr  Thr Gly Asp 
    1385                 1390                 1395             


Gly Phe  Thr Cys Thr Asp Leu  Asp Glu Cys Ser Glu  Asn Leu Asn 
    1400                 1405                 1410             


Leu Cys  Gly Asn Gly Gln Cys  Leu Asn Ala Pro Gly  Gly Tyr Arg 
    1415                 1420                 1425             


Cys Glu  Cys Asp Met Gly Phe  Val Pro Ser Ala Asp  Gly Lys Ala 
    1430                 1435                 1440             


Cys Glu  Asp Ile Asp Glu Cys  Ser Leu Pro Asn Ile  Cys Val Phe 
    1445                 1450                 1455             


Gly Thr  Cys His Asn Leu Pro  Gly Leu Phe Arg Cys  Glu Cys Glu 
    1460                 1465                 1470             


Ile Gly  Tyr Glu Leu Asp Arg  Ser Gly Gly Asn Cys  Thr Asp Val 
    1475                 1480                 1485             


Asn Glu  Cys Leu Asp Pro Thr  Thr Cys Ile Ser Gly  Asn Cys Val 
    1490                 1495                 1500             


Asn Thr  Pro Gly Ser Tyr Ile  Cys Asp Cys Pro Pro  Asp Phe Glu 
    1505                 1510                 1515             


Leu Asn  Pro Thr Arg Val Gly  Cys Val Asp Thr Arg  Ser Gly Asn 
    1520                 1525                 1530             


Cys Tyr  Leu Asp Ile Arg Pro  Arg Gly Asp Asn Gly  Asp Thr Ala 
    1535                 1540                 1545             


Cys Ser  Asn Glu Ile Gly Val  Gly Val Ser Lys Ala  Ser Cys Cys 
    1550                 1555                 1560             


Cys Ser  Leu Gly Lys Ala Trp  Gly Thr Pro Cys Glu  Met Cys Pro 
    1565                 1570                 1575             


Ala Val  Asn Thr Ser Glu Tyr  Lys Ile Leu Cys Pro  Gly Gly Glu 
    1580                 1585                 1590             


Gly Phe  Arg Pro Asn Pro Ile  Thr Val Ile Leu Glu  Asp Ile Asp 
    1595                 1600                 1605             


Glu Cys  Gln Glu Leu Pro Gly  Leu Cys Gln Gly Gly  Lys Cys Ile 
    1610                 1615                 1620             


Asn Thr  Phe Gly Ser Phe Gln  Cys Arg Cys Pro Thr  Gly Tyr Tyr 
    1625                 1630                 1635             


Leu Asn  Glu Asp Thr Arg Val  Cys Asp Asp Val Asn  Glu Cys Glu 
    1640                 1645                 1650             


Thr Pro  Gly Ile Cys Gly Pro  Gly Thr Cys Tyr Asn  Thr Val Gly 
    1655                 1660                 1665             


Asn Tyr  Thr Cys Ile Cys Pro  Pro Asp Tyr Met Gln  Val Asn Gly 
    1670                 1675                 1680             


Gly Asn  Asn Cys Met Asp Met  Arg Arg Ser Leu Cys  Tyr Arg Asn 
    1685                 1690                 1695             


Tyr Tyr  Ala Asp Asn Gln Thr  Cys Asp Gly Glu Leu  Leu Phe Asn 
    1700                 1705                 1710             


Met Thr  Lys Lys Met Cys Cys  Cys Ser Tyr Asn Ile  Gly Arg Ala 
    1715                 1720                 1725             


Trp Asn  Lys Pro Cys Glu Gln  Cys Pro Ile Pro Ser  Thr Asp Glu 
    1730                 1735                 1740             


Phe Ala  Thr Leu Cys Gly Ser  Gln Arg Pro Gly Phe  Val Ile Asp 
    1745                 1750                 1755             


Ile Tyr  Thr Gly Leu Pro Val  Asp Ile Asp Glu Cys  Arg Glu Ile 
    1760                 1765                 1770             


Pro Gly  Val Cys Glu Asn Gly  Val Cys Ile Asn Met  Val Gly Ser 
    1775                 1780                 1785             


Phe Arg  Cys Glu Cys Pro Val  Gly Phe Phe Tyr Asn  Asp Lys Leu 
    1790                 1795                 1800             


Leu Val  Cys Glu Asp Ile Asp  Glu Cys Gln Asn Gly  Pro Val Cys 
    1805                 1810                 1815             


Gln Arg  Asn Ala Glu Cys Ile  Asn Thr Ala Gly Ser  Tyr Arg Cys 
    1820                 1825                 1830             


Asp Cys  Lys Pro Gly Tyr Arg  Phe Thr Ser Thr Gly  Gln Cys Asn 
    1835                 1840                 1845             


Asp Arg  Asn Glu Cys Gln Glu  Ile Pro Asn Ile Cys  Ser His Gly 
    1850                 1855                 1860             


Gln Cys  Ile Asp Thr Val Gly  Ser Phe Tyr Cys Leu  Cys His Thr 
    1865                 1870                 1875             


Gly Phe  Lys Thr Asn Asp Asp  Gln Thr Met Cys Leu  Asp Ile Asn 
    1880                 1885                 1890             


Glu Cys  Glu Arg Asp Ala Cys  Gly Asn Gly Thr Cys  Arg Asn Thr 
    1895                 1900                 1905             


Ile Gly  Ser Phe Asn Cys Arg  Cys Asn His Gly Phe  Ile Leu Ser 
    1910                 1915                 1920             


His Asn  Asn Asp Cys Ile Asp  Val Asp Glu Cys Ala  Ser Gly Asn 
    1925                 1930                 1935             


Gly Asn  Leu Cys Arg Asn Gly  Gln Cys Ile Asn Thr  Val Gly Ser 
    1940                 1945                 1950             


Phe Gln  Cys Gln Cys Asn Glu  Gly Tyr Glu Val Ala  Pro Asp Gly 
    1955                 1960                 1965             


Arg Thr  Cys Val Asp Ile Asn  Glu Cys Leu Leu Glu  Pro Arg Lys 
    1970                 1975                 1980             


Cys Ala  Pro Gly Thr Cys Gln  Asn Leu Asp Gly Ser  Tyr Arg Cys 
    1985                 1990                 1995             


Ile Cys  Pro Pro Gly Tyr Ser  Leu Gln Asn Glu Lys  Cys Glu Asp 
    2000                 2005                 2010             


Ile Asp  Glu Cys Val Glu Glu  Pro Glu Ile Cys Ala  Leu Gly Thr 
    2015                 2020                 2025             


Cys Ser  Asn Thr Glu Gly Ser  Phe Lys Cys Leu Cys  Pro Glu Gly 
    2030                 2035                 2040             


Phe Ser  Leu Ser Ser Ser Gly  Arg Arg Cys Gln Asp  Leu Arg Met 
    2045                 2050                 2055             


Ser Tyr  Cys Tyr Ala Lys Phe  Glu Gly Gly Lys Cys  Ser Ser Pro 
    2060                 2065                 2070             


Lys Ser  Arg Asn His Ser Lys  Gln Glu Cys Cys Cys  Ala Leu Lys 
    2075                 2080                 2085             


Gly Glu  Gly Trp Gly Asp Pro  Cys Glu Leu Cys Pro  Thr Glu Pro 
    2090                 2095                 2100             


Asp Glu  Ala Phe Arg Gln Ile  Cys Pro Tyr Gly Ser  Gly Ile Ile 
    2105                 2110                 2115             


Val Gly  Pro Asp Asp Ser Ala  Val Asp Met Asp Glu  Cys Lys Glu 
    2120                 2125                 2130             


Pro Asp  Val Cys Lys His Gly  Gln Cys Ile Asn Thr  Asp Gly Ser 
    2135                 2140                 2145             


Tyr Arg  Cys Glu Cys Pro Phe  Gly Tyr Ile Leu Ala  Gly Asn Glu 
    2150                 2155                 2160             


Cys Val  Asp Thr Asp Glu Cys  Ser Val Gly Asn Pro  Cys Gly Asn 
    2165                 2170                 2175             


Gly Thr  Cys Lys Asn Val Ile  Gly Gly Phe Glu Cys  Thr Cys Glu 
    2180                 2185                 2190             


Glu Gly  Phe Glu Pro Gly Pro  Met Met Thr Cys Glu  Asp Ile Asn 
    2195                 2200                 2205             


Glu Cys  Ala Gln Asn Pro Leu  Leu Cys Ala Phe Arg  Cys Val Asn 
    2210                 2215                 2220             


Thr Tyr  Gly Ser Tyr Glu Cys  Lys Cys Pro Val Gly  Tyr Val Leu 
    2225                 2230                 2235             


Arg Glu  Asp Arg Arg Met Cys  Lys Asp Glu Asp Glu  Cys Glu Glu 
    2240                 2245                 2250             


Gly Lys  His Asp Cys Thr Glu  Lys Gln Met Glu Cys  Lys Asn Leu 
    2255                 2260                 2265             


Ile Gly  Thr Tyr Met Cys Ile  Cys Gly Pro Gly Tyr  Gln Arg Arg 
    2270                 2275                 2280             


Pro Asp  Gly Glu Gly Cys Val  Asp Glu Asn Glu Cys  Gln Thr Lys 
    2285                 2290                 2295             


Pro Gly  Ile Cys Glu Asn Gly  Arg Cys Leu Asn Thr  Arg Gly Ser 
    2300                 2305                 2310             


Tyr Thr  Cys Glu Cys Asn Asp  Gly Phe Thr Ala Ser  Pro Asn Gln 
    2315                 2320                 2325             


Asp Glu  Cys Leu Asp Asn Arg  Glu Gly Tyr Cys Phe  Thr Glu Val 
    2330                 2335                 2340             


Leu Gln  Asn Met Cys Gln Ile  Gly Ser Ser Asn Arg  Asn Pro Val 
    2345                 2350                 2355             


Thr Lys  Ser Glu Cys Cys Cys  Asp Gly Gly Arg Gly  Trp Gly Pro 
    2360                 2365                 2370             


His Cys  Glu Ile Cys Pro Phe  Gln Gly Thr Val Ala  Phe Lys Lys 
    2375                 2380                 2385             


Leu Cys  Pro His Gly Arg Gly  Phe Met Thr Asn Gly  Ala Asp Ile 
    2390                 2395                 2400             


Asp Glu  Cys Lys Val Ile His  Asp Val Cys Arg Asn  Gly Glu Cys 
    2405                 2410                 2415             


Val Asn  Asp Arg Gly Ser Tyr  His Cys Ile Cys Lys  Thr Gly Tyr 
    2420                 2425                 2430             


Thr Pro  Asp Ile Thr Gly Thr  Ser Cys Val Asp Leu  Asn Glu Cys 
    2435                 2440                 2445             


Asn Gln  Ala Pro Lys Pro Cys  Asn Phe Ile Cys Lys  Asn Thr Glu 
    2450                 2455                 2460             


Gly Ser  Tyr Gln Cys Ser Cys  Pro Lys Gly Tyr Ile  Leu Gln Glu 
    2465                 2470                 2475             


Asp Gly  Arg Ser Cys Lys Asp  Leu Asp Glu Cys Ala  Thr Lys Gln 
    2480                 2485                 2490             


His Asn  Cys Gln Phe Leu Cys  Val Asn Thr Ile Gly  Gly Phe Thr 
    2495                 2500                 2505             


Cys Lys  Cys Pro Pro Gly Phe  Thr Gln His His Thr  Ser Cys Ile 
    2510                 2515                 2520             


Asp Asn  Asn Glu Cys Thr Ser  Asp Ile Asn Leu Cys  Gly Ser Lys 
    2525                 2530                 2535             


Gly Ile  Cys Gln Asn Thr Pro  Gly Ser Phe Thr Cys  Glu Cys Gln 
    2540                 2545                 2550             


Arg Gly  Phe Ser Leu Asp Gln  Thr Gly Ser Ser Cys  Glu Asp Val 
    2555                 2560                 2565             


Asp Glu  Cys Glu Gly Asn His  Arg Cys Gln His Gly  Cys Gln Asn 
    2570                 2575                 2580             


Ile Ile  Gly Gly Tyr Arg Cys  Ser Cys Pro Gln Gly  Tyr Leu Gln 
    2585                 2590                 2595             


His Tyr  Gln Trp Asn Gln Cys  Val Asp Glu Asn Glu  Cys Leu Ser 
    2600                 2605                 2610             


Ala His  Ile Cys Gly Gly Ala  Ser Cys His Asn Thr  Leu Gly Ser 
    2615                 2620                 2625             


Tyr Lys  Cys Met Cys Pro Ala  Gly Phe Gln Tyr Glu  Gln Phe Ser 
    2630                 2635                 2640             


Gly Gly  Cys Gln Asp Ile Asn  Glu Cys Gly Ser Ala  Gln Ala Pro 
    2645                 2650                 2655             


Cys Ser  Tyr Gly Cys Ser Asn  Thr Glu Gly Gly Tyr  Leu Cys Gly 
    2660                 2665                 2670             


Cys Pro  Pro Gly Tyr Phe Arg  Ile Gly Gln Gly His  Cys Val Ser 
    2675                 2680                 2685             


Gly Met  Gly Met Gly Arg Gly  Asn Pro Glu Pro Pro  Val Ser Gly 
    2690                 2695                 2700             


Glu Met  Asp Asp Asn Ser Leu  Ser Pro Glu Ala Cys  Tyr Glu Cys 
    2705                 2710                 2715             


Lys Ile  Asn Gly Tyr Pro Lys  Arg Gly Arg Lys Arg  Arg Ser Thr 
    2720                 2725                 2730             


Asn Glu  Thr Asp Ala Ser Asn  Ile Glu Asp Gln Ser  Glu Thr Glu 
    2735                 2740                 2745             


Ala Asn  Val Ser Leu Ala Ser  Trp Asp Val Glu Lys  Thr Ala Ile 
    2750                 2755                 2760             


Phe Ala  Phe Asn Ile Ser His  Val Ser Asn Lys Val  Arg Ile Leu 
    2765                 2770                 2775             


Glu Leu  Leu Pro Ala Leu Thr  Thr Leu Thr Asn His  Asn Arg Tyr 
    2780                 2785                 2790             


Leu Ile  Glu Ser Gly Asn Glu  Asp Gly Phe Phe Lys  Ile Asn Gln 
    2795                 2800                 2805             


Lys Glu  Gly Ile Ser Tyr Leu  His Phe Thr Lys Lys  Lys Pro Val 
    2810                 2815                 2820             


Ala Gly  Thr Tyr Ser Leu Gln  Ile Ser Ser Thr Pro  Leu Tyr Lys 
    2825                 2830                 2835             


Lys Lys  Glu Leu Asn Gln Leu  Glu Asp Lys Tyr Asp  Lys Asp Tyr 
    2840                 2845                 2850             


Leu Ser  Gly Glu Leu Gly Asp  Asn Leu Lys Met Lys  Ile Gln Val 
    2855                 2860                 2865             


Leu Leu  His 
    2870     


<210>  5155
<211>  853
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5155

Xaa Leu Gly Lys Ala Trp Gly Thr Pro Cys Glu Met Cys Pro Ala Val 
1               5                   10                  15      


Asn Thr Ser Glu Tyr Lys Ile Leu Cys Pro Gly Gly Glu Gly Phe Arg 
            20                  25                  30          


Pro Asn Pro Ile Thr Val Ile Leu Glu Asp Ile Asp Glu Cys Gln Glu 
        35                  40                  45              


Leu Pro Gly Leu Cys Gln Gly Gly Lys Cys Ile Asn Thr Phe Gly Ser 
    50                  55                  60                  


Phe Gln Cys Arg Cys Pro Thr Gly Tyr Tyr Leu Asn Glu Asp Thr Arg 
65                  70                  75                  80  


Val Cys Asp Asp Val Asn Glu Cys Glu Thr Pro Gly Ile Cys Gly Pro 
                85                  90                  95      


Gly Thr Cys Tyr Asn Thr Val Gly Asn Tyr Thr Cys Ile Cys Pro Pro 
            100                 105                 110         


Asp Tyr Met Gln Val Asn Gly Gly Asn Asn Cys Met Asp Met Arg Arg 
        115                 120                 125             


Ser Leu Cys Tyr Arg Asn Tyr Tyr Ala Asp Asn Gln Thr Cys Asp Gly 
    130                 135                 140                 


Glu Leu Leu Phe Asn Met Thr Lys Lys Met Cys Cys Cys Ser Tyr Asn 
145                 150                 155                 160 


Ile Gly Arg Ala Trp Asn Lys Pro Cys Glu Gln Cys Pro Ile Pro Ser 
                165                 170                 175     


Thr Asp Glu Phe Ala Thr Leu Cys Gly Ser Gln Arg Pro Gly Phe Val 
            180                 185                 190         


Ile Asp Ile Tyr Thr Gly Leu Pro Val Asp Ile Asp Glu Cys Arg Glu 
        195                 200                 205             


Ile Pro Gly Val Cys Glu Asn Gly Val Cys Ile Asn Met Val Gly Ser 
    210                 215                 220                 


Phe Arg Cys Glu Cys Pro Val Gly Phe Phe Tyr Asn Asp Lys Leu Leu 
225                 230                 235                 240 


Val Cys Glu Asp Ile Asp Glu Cys Gln Asn Gly Pro Val Cys Gln Arg 
                245                 250                 255     


Asn Ala Glu Cys Ile Asn Thr Ala Gly Ser Tyr Arg Cys Asp Cys Lys 
            260                 265                 270         


Pro Gly Tyr Arg Phe Thr Ser Thr Gly Gln Cys Asn Asp Arg Asn Glu 
        275                 280                 285             


Cys Gln Glu Ile Pro Asn Ile Cys Ser His Gly Gln Cys Ile Asp Thr 
    290                 295                 300                 


Val Gly Ser Phe Tyr Cys Leu Cys His Thr Gly Phe Lys Thr Asn Asp 
305                 310                 315                 320 


Asp Gln Thr Met Cys Leu Asp Ile Asn Glu Cys Glu Arg Asp Ala Cys 
                325                 330                 335     


Gly Asn Gly Thr Cys Arg Asn Thr Ile Gly Ser Phe Asn Cys Arg Cys 
            340                 345                 350         


Asn His Gly Phe Ile Leu Ser His Asn Asn Asp Cys Ile Asp Val Asp 
        355                 360                 365             


Glu Cys Ala Ser Gly Asn Gly Asn Leu Cys Arg Asn Gly Gln Cys Ile 
    370                 375                 380                 


Asn Thr Val Gly Ser Phe Gln Cys Gln Cys Asn Glu Gly Tyr Glu Val 
385                 390                 395                 400 


Ala Pro Asp Gly Arg Thr Cys Val Asp Ile Asn Glu Cys Leu Leu Glu 
                405                 410                 415     


Pro Arg Lys Cys Ala Pro Gly Thr Cys Gln Asn Leu Asp Gly Ser Tyr 
            420                 425                 430         


Arg Cys Ile Cys Pro Pro Gly Tyr Ser Leu Gln Asn Glu Lys Cys Glu 
        435                 440                 445             


Asp Ile Asp Glu Cys Val Glu Glu Pro Glu Ile Cys Ala Leu Gly Thr 
    450                 455                 460                 


Cys Ser Asn Thr Glu Gly Ser Phe Lys Cys Leu Cys Pro Glu Gly Phe 
465                 470                 475                 480 


Ser Leu Ser Ser Ser Gly Arg Arg Cys Gln Asp Leu Arg Met Ser Tyr 
                485                 490                 495     


Cys Tyr Ala Lys Phe Glu Gly Gly Lys Cys Ser Ser Pro Lys Ser Arg 
            500                 505                 510         


Asn His Ser Lys Gln Glu Cys Cys Cys Ala Leu Lys Gly Glu Gly Trp 
        515                 520                 525             


Gly Asp Pro Cys Glu Leu Cys Pro Thr Glu Pro Asp Glu Ala Phe Arg 
    530                 535                 540                 


Gln Ile Cys Pro Tyr Gly Ser Gly Ile Ile Val Gly Pro Asp Asp Ser 
545                 550                 555                 560 


Ala Val Asp Met Asp Glu Cys Lys Glu Pro Asp Val Cys Lys His Gly 
                565                 570                 575     


Gln Cys Ile Asn Thr Asp Gly Ser Tyr Arg Cys Glu Cys Pro Phe Gly 
            580                 585                 590         


Tyr Ile Leu Ala Gly Asn Glu Cys Val Asp Thr Asp Glu Cys Ser Val 
        595                 600                 605             


Gly Asn Pro Cys Gly Asn Gly Thr Cys Lys Asn Val Ile Gly Gly Phe 
    610                 615                 620                 


Glu Cys Thr Cys Glu Glu Gly Phe Glu Pro Gly Pro Met Met Thr Cys 
625                 630                 635                 640 


Glu Asp Ile Asn Glu Cys Ala Gln Asn Pro Leu Leu Cys Ala Phe Arg 
                645                 650                 655     


Cys Val Asn Thr Tyr Gly Ser Tyr Glu Cys Lys Cys Pro Val Gly Tyr 
            660                 665                 670         


Val Leu Arg Glu Asp Arg Arg Met Cys Lys Asp Glu Asp Glu Cys Glu 
        675                 680                 685             


Glu Gly Lys His Asp Cys Thr Glu Lys Gln Met Glu Cys Lys Asn Leu 
    690                 695                 700                 


Ile Gly Thr Tyr Met Cys Ile Cys Gly Pro Gly Tyr Gln Arg Arg Pro 
705                 710                 715                 720 


Asp Gly Glu Gly Cys Val Asp Glu Asn Glu Cys Gln Thr Lys Pro Gly 
                725                 730                 735     


Ile Cys Glu Asn Gly Arg Cys Leu Asn Thr Arg Gly Ser Tyr Thr Cys 
            740                 745                 750         


Glu Cys Asn Asp Gly Phe Thr Ala Ser Pro Asn Gln Asp Glu Cys Leu 
        755                 760                 765             


Asp Val Ile Leu Ser Leu Leu Leu Leu Ser Pro Ala Phe Pro Ser Cys 
    770                 775                 780                 


Phe Phe Ser Pro Arg Thr Ile Gly Lys Gly Thr Ala Ser Gln Arg Cys 
785                 790                 795                 800 


Tyr Lys Thr Cys Val Arg Ser Ala Pro Ala Thr Gly Thr Pro Ser Pro 
                805                 810                 815     


Asn Arg Asn Ala Ala Val Thr Glu Gly Glu Ala Gly Val Pro Thr Val 
            820                 825                 830         


Arg Ser Ala Leu Ser Arg Gly Leu Trp Leu Ser Arg Asn Ser Val Pro 
        835                 840                 845             


Met Ala Glu Asp Ser 
    850             


<210>  5156
<211>  1473
<212>  PRT
<213>  Homo Sapiens

<400>  5156

Met Gly Arg Arg Arg Arg Leu Cys Leu Gln Leu Tyr Phe Leu Trp Leu 
1               5                   10                  15      


Gly Cys Val Val Leu Trp Ala Gln Gly Thr Ala Gly Gln Pro Gln Pro 
            20                  25                  30          


Pro Pro Pro Lys Pro Pro Arg Pro Gln Pro Pro Pro Gln Gln Val Arg 
        35                  40                  45              


Ser Ala Thr Ala Gly Ser Glu Gly Gly Phe Leu Ala Pro Glu Tyr Arg 
    50                  55                  60                  


Glu Glu Gly Ala Ala Val Ala Ser Arg Val Arg Arg Arg Gly Gln Gln 
65                  70                  75                  80  


Asp Val Leu Arg Gly Pro Asn Val Cys Gly Ser Arg Phe His Ser Tyr 
                85                  90                  95      


Cys Cys Pro Gly Trp Lys Thr Leu Pro Gly Gly Asn Gln Cys Ile Val 
            100                 105                 110         


Leu Gln Gln Cys Ser Val Arg Cys Met Asn Gly Gly Thr Cys Ala Asp 
        115                 120                 125             


Asp His Cys Gln Cys Gln Lys Gly Tyr Ile Gly Thr Tyr Cys Gly Gln 
    130                 135                 140                 


Pro Val Cys Glu Asn Gly Cys Gln Asn Gly Gly Arg Cys Ile Gly Pro 
145                 150                 155                 160 


Asn Arg Cys Ala Cys Val Tyr Gly Phe Thr Gly Pro Gln Cys Glu Arg 
                165                 170                 175     


Asp Tyr Arg Thr Gly Pro Cys Phe Thr Gln Val Asn Asn Gln Met Cys 
            180                 185                 190         


Gln Gly Gln Leu Thr Gly Ile Val Cys Thr Lys Thr Leu Cys Cys Ala 
        195                 200                 205             


Thr Ile Gly Arg Ala Trp Gly His Pro Cys Glu Met Cys Pro Ala Gln 
    210                 215                 220                 


Pro Gln Pro Cys Arg Arg Gly Phe Ile Pro Asn Ile Arg Thr Gly Ala 
225                 230                 235                 240 


Cys Gln Asp Val Asp Glu Cys Gln Ala Ile Pro Gly Ile Cys Gln Gly 
                245                 250                 255     


Gly Asn Cys Ile Asn Thr Val Gly Ser Phe Glu Cys Arg Cys Pro Ala 
            260                 265                 270         


Gly His Lys Gln Ser Glu Thr Thr Gln Lys Cys Glu Asp Ile Asp Glu 
        275                 280                 285             


Cys Ser Ile Ile Pro Gly Ile Cys Glu Thr Gly Glu Cys Ser Asn Thr 
    290                 295                 300                 


Val Gly Ser Tyr Phe Cys Val Cys Pro Arg Gly Tyr Val Thr Ser Thr 
305                 310                 315                 320 


Asp Gly Ser Arg Cys Ile Asp Gln Arg Thr Gly Met Cys Phe Ser Gly 
                325                 330                 335     


Leu Val Asn Gly Arg Cys Ala Gln Glu Leu Pro Gly Arg Met Thr Lys 
            340                 345                 350         


Met Gln Cys Cys Cys Glu Pro Gly Arg Cys Trp Gly Ile Gly Thr Ile 
        355                 360                 365             


Pro Glu Ala Cys Pro Val Arg Gly Ser Glu Glu Tyr Arg Arg Leu Cys 
    370                 375                 380                 


Met Asp Gly Leu Pro Met Gly Gly Ile Pro Gly Ser Ala Gly Ser Arg 
385                 390                 395                 400 


Pro Gly Gly Thr Gly Gly Asn Gly Phe Ala Pro Ser Gly Asn Gly Asn 
                405                 410                 415     


Gly Tyr Gly Pro Gly Gly Thr Gly Phe Ile Pro Ile Pro Gly Gly Asn 
            420                 425                 430         


Gly Phe Ser Pro Gly Val Gly Gly Ala Gly Val Gly Ala Gly Gly Gln 
        435                 440                 445             


Gly Pro Ile Ile Thr Gly Leu Thr Ile Leu Asn Gln Thr Ile Asp Ile 
    450                 455                 460                 


Cys Lys His His Ala Asn Leu Cys Leu Asn Gly Arg Cys Ile Pro Thr 
465                 470                 475                 480 


Val Ser Ser Tyr Arg Cys Glu Cys Asn Met Gly Tyr Lys Gln Asp Ala 
                485                 490                 495     


Asn Gly Asp Cys Ile Asp Val Asp Glu Cys Thr Ser Asn Pro Cys Thr 
            500                 505                 510         


Asn Gly Asp Cys Val Asn Thr Pro Gly Ser Tyr Tyr Cys Lys Cys His 
        515                 520                 525             


Ala Gly Phe Gln Arg Thr Pro Thr Lys Gln Ala Cys Ile Asp Ile Asp 
    530                 535                 540                 


Glu Cys Ile Gln Asn Gly Val Leu Cys Lys Asn Gly Arg Cys Val Asn 
545                 550                 555                 560 


Thr Asp Gly Ser Phe Gln Cys Ile Cys Asn Ala Gly Phe Glu Leu Thr 
                565                 570                 575     


Thr Asp Gly Lys Asn Cys Val Asp His Asp Glu Cys Thr Thr Thr Asn 
            580                 585                 590         


Met Cys Leu Asn Gly Met Cys Ile Asn Glu Asp Gly Ser Phe Lys Cys 
        595                 600                 605             


Ile Cys Lys Pro Gly Phe Val Leu Ala Pro Asn Gly Arg Tyr Cys Thr 
    610                 615                 620                 


Asp Val Asp Glu Cys Gln Thr Pro Gly Ile Cys Met Asn Gly His Cys 
625                 630                 635                 640 


Ile Asn Ser Glu Gly Ser Phe Arg Cys Asp Cys Pro Pro Gly Leu Ala 
                645                 650                 655     


Val Gly Met Asp Gly Arg Val Cys Val Asp Thr His Met Arg Ser Thr 
            660                 665                 670         


Cys Tyr Gly Gly Ile Lys Lys Gly Val Cys Val Arg Pro Phe Pro Gly 
        675                 680                 685             


Ala Val Thr Lys Ser Glu Cys Cys Cys Ala Asn Pro Asp Tyr Gly Phe 
    690                 695                 700                 


Gly Glu Pro Cys Gln Pro Cys Pro Ala Lys Asn Ser Ala Glu Phe His 
705                 710                 715                 720 


Gly Leu Cys Ser Ser Gly Val Gly Ile Thr Val Asp Gly Arg Asp Ile 
                725                 730                 735     


Asn Glu Cys Ala Leu Asp Pro Asp Ile Cys Ala Asn Gly Ile Cys Glu 
            740                 745                 750         


Asn Leu Arg Gly Ser Tyr Arg Cys Asn Cys Asn Ser Gly Tyr Glu Pro 
        755                 760                 765             


Asp Ala Ser Gly Arg Asn Cys Ile Asp Ile Asp Glu Cys Leu Val Asn 
    770                 775                 780                 


Arg Leu Leu Cys Asp Asn Gly Leu Cys Arg Asn Thr Pro Gly Ser Tyr 
785                 790                 795                 800 


Ser Cys Thr Cys Pro Pro Gly Tyr Val Phe Arg Thr Glu Thr Glu Thr 
                805                 810                 815     


Cys Glu Asp Ile Asn Glu Cys Glu Ser Asn Pro Cys Val Asn Gly Ala 
            820                 825                 830         


Cys Arg Asn Asn Leu Gly Ser Phe Asn Cys Glu Cys Ser Pro Gly Ser 
        835                 840                 845             


Lys Leu Ser Ser Thr Gly Leu Ile Cys Ile Asp Ser Leu Lys Gly Thr 
    850                 855                 860                 


Cys Trp Leu Asn Ile Gln Asp Ser Arg Cys Glu Val Asn Ile Asn Gly 
865                 870                 875                 880 


Ala Thr Leu Lys Ser Glu Cys Cys Ala Thr Leu Gly Ala Ala Trp Gly 
                885                 890                 895     


Ser Pro Cys Glu Arg Cys Glu Leu Asp Thr Ala Cys Pro Arg Gly Leu 
            900                 905                 910         


Ala Arg Ile Lys Gly Val Thr Cys Glu Asp Val Asn Glu Cys Glu Val 
        915                 920                 925             


Phe Pro Gly Val Cys Pro Asn Gly Arg Cys Val Asn Ser Lys Gly Ser 
    930                 935                 940                 


Phe His Cys Glu Cys Pro Glu Gly Leu Thr Leu Asp Gly Thr Gly Arg 
945                 950                 955                 960 


Val Cys Leu Asp Ile Arg Met Glu Gln Cys Tyr Leu Lys Trp Asp Glu 
                965                 970                 975     


Asp Glu Cys Ile His Pro Val Pro Gly Lys Phe Arg Met Asp Ala Cys 
            980                 985                 990         


Cys Cys Ala Val Gly Ala Ala Trp  Gly Thr Glu Cys Glu  Glu Cys Pro 
        995                 1000                 1005             


Lys Pro  Gly Thr Lys Glu Tyr  Glu Thr Leu Cys Pro  Arg Gly Ala 
    1010                 1015                 1020             


Gly Phe  Ala Asn Arg Gly Asp  Val Leu Thr Gly Arg  Pro Phe Tyr 
    1025                 1030                 1035             


Lys Asp  Ile Asn Glu Cys Lys  Ala Phe Pro Gly Met  Cys Thr Tyr 
    1040                 1045                 1050             


Gly Lys  Cys Arg Asn Thr Ile  Gly Ser Phe Lys Cys  Arg Cys Asn 
    1055                 1060                 1065             


Ser Gly  Phe Ala Leu Asp Met  Glu Glu Arg Asn Cys  Thr Asp Ile 
    1070                 1075                 1080             


Asp Glu  Cys Arg Ile Ser Pro  Asp Leu Cys Gly Ser  Gly Ile Cys 
    1085                 1090                 1095             


Val Asn  Thr Pro Gly Ser Phe  Glu Cys Glu Cys Phe  Glu Gly Tyr 
    1100                 1105                 1110             


Glu Ser  Gly Phe Met Met Met  Lys Asn Cys Met Asp  Ile Asp Glu 
    1115                 1120                 1125             


Cys Glu  Arg Asn Pro Leu Leu  Cys Arg Gly Gly Thr  Cys Val Asn 
    1130                 1135                 1140             


Thr Glu  Gly Ser Phe Gln Cys  Asp Cys Pro Leu Gly  His Glu Leu 
    1145                 1150                 1155             


Ser Pro  Ser Arg Glu Asp Cys  Val Asp Ile Asn Glu  Cys Ser Leu 
    1160                 1165                 1170             


Ser Asp  Asn Leu Cys Arg Asn  Gly Lys Cys Val Asn  Met Ile Gly 
    1175                 1180                 1185             


Thr Tyr  Gln Cys Ser Cys Asn  Pro Gly Tyr Gln Ala  Thr Pro Asp 
    1190                 1195                 1200             


Arg Gln  Gly Cys Thr Asp Ile  Asp Glu Cys Met Ile  Met Asn Gly 
    1205                 1210                 1215             


Gly Cys  Asp Thr Gln Cys Thr  Asn Ser Glu Gly Ser  Tyr Glu Cys 
    1220                 1225                 1230             


Ser Cys  Ser Glu Gly Tyr Ala  Leu Met Pro Asp Gly  Arg Ser Cys 
    1235                 1240                 1245             


Ala Asp  Ile Asp Glu Cys Glu  Asn Asn Pro Asp Ile  Cys Asp Gly 
    1250                 1255                 1260             


Gly Gln  Cys Thr Asn Ile Pro  Gly Glu Tyr Arg Cys  Leu Cys Tyr 
    1265                 1270                 1275             


Asp Gly  Phe Met Ala Ser Met  Asp Met Lys Thr Cys  Ile Asp Val 
    1280                 1285                 1290             


Asn Glu  Cys Asp Leu Asn Ser  Asn Ile Cys Met Phe  Gly Glu Cys 
    1295                 1300                 1305             


Glu Asn  Thr Lys Gly Ser Phe  Ile Cys His Cys Gln  Leu Gly Tyr 
    1310                 1315                 1320             


Ser Val  Lys Lys Gly Thr Thr  Gly Cys Thr Asp Val  Asp Glu Cys 
    1325                 1330                 1335             


Glu Ile  Gly Ala His Asn Cys  Asp Met His Ala Ser  Cys Leu Asn 
    1340                 1345                 1350             


Ile Pro  Gly Ser Phe Lys Cys  Ser Cys Arg Glu Gly  Trp Ile Gly 
    1355                 1360                 1365             


Asn Gly  Ile Lys Cys Ile Asp  Leu Asp Glu Cys Ser  Asn Gly Thr 
    1370                 1375                 1380             


His Gln  Cys Ser Ile Asn Ala  Gln Cys Val Asn Thr  Pro Gly Ser 
    1385                 1390                 1395             


Tyr Arg  Cys Ala Cys Ser Glu  Gly Phe Thr Gly Asp  Gly Phe Thr 
    1400                 1405                 1410             


Cys Ser  Asp Val Asp Glu Cys  Ala Glu Asn Ile Asn  Leu Cys Glu 
    1415                 1420                 1425             


Asn Gly  Gln Cys Leu Asn Val  Pro Gly Ala Tyr Arg  Cys Glu Cys 
    1430                 1435                 1440             


Glu Met  Gly Phe Thr Pro Ala  Ser Asp Ser Arg Ser  Cys Gln Gly 
    1445                 1450                 1455             


Gly Ser  Pro Gly Phe Gln Leu  Ile Phe Lys Leu Asp  Gln Pro Gln 
    1460                 1465                 1470             


<210>  5157
<211>  2912
<212>  PRT
<213>  Homo Sapiens

<400>  5157

Met Gly Arg Arg Arg Arg Leu Cys Leu Gln Leu Tyr Phe Leu Trp Leu 
1               5                   10                  15      


Gly Cys Val Val Leu Trp Ala Gln Gly Thr Ala Gly Gln Pro Gln Pro 
            20                  25                  30          


Pro Pro Pro Lys Pro Pro Arg Pro Gln Pro Pro Pro Gln Gln Val Arg 
        35                  40                  45              


Ser Ala Thr Ala Gly Ser Glu Gly Gly Phe Leu Ala Pro Glu Tyr Arg 
    50                  55                  60                  


Glu Glu Gly Ala Ala Val Ala Ser Arg Val Arg Arg Arg Gly Gln Gln 
65                  70                  75                  80  


Asp Val Leu Arg Gly Pro Asn Val Cys Gly Ser Arg Phe His Ser Tyr 
                85                  90                  95      


Cys Cys Pro Gly Trp Lys Thr Leu Pro Gly Gly Asn Gln Cys Ile Val 
            100                 105                 110         


Pro Ile Cys Arg Asn Ser Cys Gly Asp Gly Phe Cys Ser Arg Pro Asn 
        115                 120                 125             


Met Cys Thr Cys Ser Ser Gly Gln Ile Ser Ser Thr Cys Gly Ser Lys 
    130                 135                 140                 


Ser Ile Gln Gln Cys Ser Val Arg Cys Met Asn Gly Gly Thr Cys Ala 
145                 150                 155                 160 


Asp Asp His Cys Gln Cys Gln Lys Gly Tyr Ile Gly Thr Tyr Cys Gly 
                165                 170                 175     


Gln Pro Val Cys Glu Asn Gly Cys Gln Asn Gly Gly Arg Cys Ile Gly 
            180                 185                 190         


Pro Asn Arg Cys Ala Cys Val Tyr Gly Phe Thr Gly Pro Gln Cys Glu 
        195                 200                 205             


Arg Asp Tyr Arg Thr Gly Pro Cys Phe Thr Gln Val Asn Asn Gln Met 
    210                 215                 220                 


Cys Gln Gly Gln Leu Thr Gly Ile Val Cys Thr Lys Thr Leu Cys Cys 
225                 230                 235                 240 


Ala Thr Ile Gly Arg Ala Trp Gly His Pro Cys Glu Met Cys Pro Ala 
                245                 250                 255     


Gln Pro Gln Pro Cys Arg Arg Gly Phe Ile Pro Asn Ile Arg Thr Gly 
            260                 265                 270         


Ala Cys Gln Asp Val Asp Glu Cys Gln Ala Ile Pro Gly Ile Cys Gln 
        275                 280                 285             


Gly Gly Asn Cys Ile Asn Thr Val Gly Ser Phe Glu Cys Arg Cys Pro 
    290                 295                 300                 


Ala Gly His Lys Gln Ser Glu Thr Thr Gln Lys Cys Glu Asp Ile Asp 
305                 310                 315                 320 


Glu Cys Ser Ile Ile Pro Gly Ile Cys Glu Thr Gly Glu Cys Ser Asn 
                325                 330                 335     


Thr Val Gly Ser Tyr Phe Cys Val Cys Pro Arg Gly Tyr Val Thr Ser 
            340                 345                 350         


Thr Asp Gly Ser Arg Cys Ile Asp Gln Arg Thr Gly Met Cys Phe Ser 
        355                 360                 365             


Gly Leu Val Asn Gly Arg Cys Ala Gln Glu Leu Pro Gly Arg Met Thr 
    370                 375                 380                 


Lys Met Gln Cys Cys Cys Glu Pro Gly Arg Cys Trp Gly Ile Gly Thr 
385                 390                 395                 400 


Ile Pro Glu Ala Cys Pro Val Arg Gly Ser Glu Glu Tyr Arg Arg Leu 
                405                 410                 415     


Cys Met Asp Gly Leu Pro Met Gly Gly Ile Pro Gly Ser Ala Gly Ser 
            420                 425                 430         


Arg Pro Gly Gly Thr Gly Gly Asn Gly Phe Ala Pro Ser Gly Asn Gly 
        435                 440                 445             


Asn Gly Tyr Gly Pro Gly Gly Thr Gly Phe Ile Pro Ile Pro Gly Gly 
    450                 455                 460                 


Asn Gly Phe Ser Pro Gly Val Gly Gly Ala Gly Val Gly Ala Gly Gly 
465                 470                 475                 480 


Gln Gly Pro Ile Ile Thr Gly Leu Thr Ile Leu Asn Gln Thr Ile Asp 
                485                 490                 495     


Ile Cys Lys His His Ala Asn Leu Cys Leu Asn Gly Arg Cys Ile Pro 
            500                 505                 510         


Thr Val Ser Ser Tyr Arg Cys Glu Cys Asn Met Gly Tyr Lys Gln Asp 
        515                 520                 525             


Ala Asn Gly Asp Cys Ile Asp Val Asp Glu Cys Thr Ser Asn Pro Cys 
    530                 535                 540                 


Thr Asn Gly Asp Cys Val Asn Thr Pro Gly Ser Tyr Tyr Cys Lys Cys 
545                 550                 555                 560 


His Ala Gly Phe Gln Arg Thr Pro Thr Lys Gln Ala Cys Ile Asp Ile 
                565                 570                 575     


Asp Glu Cys Ile Gln Asn Gly Val Leu Cys Lys Asn Gly Arg Cys Val 
            580                 585                 590         


Asn Thr Asp Gly Ser Phe Gln Cys Ile Cys Asn Ala Gly Phe Glu Leu 
        595                 600                 605             


Thr Thr Asp Gly Lys Asn Cys Val Asp His Asp Glu Cys Thr Thr Thr 
    610                 615                 620                 


Asn Met Cys Leu Asn Gly Met Cys Ile Asn Glu Asp Gly Ser Phe Lys 
625                 630                 635                 640 


Cys Ile Cys Lys Pro Gly Phe Val Leu Ala Pro Asn Gly Arg Tyr Cys 
                645                 650                 655     


Thr Asp Val Asp Glu Cys Gln Thr Pro Gly Ile Cys Met Asn Gly His 
            660                 665                 670         


Cys Ile Asn Ser Glu Gly Ser Phe Arg Cys Asp Cys Pro Pro Gly Leu 
        675                 680                 685             


Ala Val Gly Met Asp Gly Arg Val Cys Val Asp Thr His Met Arg Ser 
    690                 695                 700                 


Thr Cys Tyr Gly Gly Ile Lys Lys Gly Val Cys Val Arg Pro Phe Pro 
705                 710                 715                 720 


Gly Ala Val Thr Lys Ser Glu Cys Cys Cys Ala Asn Pro Asp Tyr Gly 
                725                 730                 735     


Phe Gly Glu Pro Cys Gln Pro Cys Pro Ala Lys Asn Ser Ala Glu Phe 
            740                 745                 750         


His Gly Leu Cys Ser Ser Gly Val Gly Ile Thr Val Asp Gly Arg Asp 
        755                 760                 765             


Ile Asn Glu Cys Ala Leu Asp Pro Asp Ile Cys Ala Asn Gly Ile Cys 
    770                 775                 780                 


Glu Asn Leu Arg Gly Ser Tyr Arg Cys Asn Cys Asn Ser Gly Tyr Glu 
785                 790                 795                 800 


Pro Asp Ala Ser Gly Arg Asn Cys Ile Asp Ile Asp Glu Cys Leu Val 
                805                 810                 815     


Asn Arg Leu Leu Cys Asp Asn Gly Leu Cys Arg Asn Thr Pro Gly Ser 
            820                 825                 830         


Tyr Ser Cys Thr Cys Pro Pro Gly Tyr Val Phe Arg Thr Glu Thr Glu 
        835                 840                 845             


Thr Cys Glu Asp Ile Asn Glu Cys Glu Ser Asn Pro Cys Val Asn Gly 
    850                 855                 860                 


Ala Cys Arg Asn Asn Leu Gly Ser Phe Asn Cys Glu Cys Ser Pro Gly 
865                 870                 875                 880 


Ser Lys Leu Ser Ser Thr Gly Leu Ile Cys Ile Asp Ser Leu Lys Gly 
                885                 890                 895     


Thr Cys Trp Leu Asn Ile Gln Asp Ser Arg Cys Glu Val Asn Ile Asn 
            900                 905                 910         


Gly Ala Thr Leu Lys Ser Glu Cys Cys Ala Thr Leu Gly Ala Ala Trp 
        915                 920                 925             


Gly Ser Pro Cys Glu Arg Cys Glu Leu Asp Thr Ala Cys Pro Arg Gly 
    930                 935                 940                 


Leu Ala Arg Ile Lys Gly Val Thr Cys Glu Asp Val Asn Glu Cys Glu 
945                 950                 955                 960 


Val Phe Pro Gly Val Cys Pro Asn Gly Arg Cys Val Asn Ser Lys Gly 
                965                 970                 975     


Ser Phe His Cys Glu Cys Pro Glu Gly Leu Thr Leu Asp Gly Thr Gly 
            980                 985                 990         


Arg Val Cys Leu Asp Ile Arg Met  Glu Gln Cys Tyr Leu  Lys Trp Asp 
        995                 1000                 1005             


Glu Asp  Glu Cys Ile His Pro  Val Pro Gly Lys Phe  Arg Met Asp 
    1010                 1015                 1020             


Ala Cys  Cys Cys Ala Val Gly  Ala Ala Trp Gly Thr  Glu Cys Glu 
    1025                 1030                 1035             


Glu Cys  Pro Lys Pro Gly Thr  Lys Glu Tyr Glu Thr  Leu Cys Pro 
    1040                 1045                 1050             


Arg Gly  Ala Gly Phe Ala Asn  Arg Gly Asp Val Leu  Thr Gly Arg 
    1055                 1060                 1065             


Pro Phe  Tyr Lys Asp Ile Asn  Glu Cys Lys Ala Phe  Pro Gly Met 
    1070                 1075                 1080             


Cys Thr  Tyr Gly Lys Cys Arg  Asn Thr Ile Gly Ser  Phe Lys Cys 
    1085                 1090                 1095             


Arg Cys  Asn Ser Gly Phe Ala  Leu Asp Met Glu Glu  Arg Asn Cys 
    1100                 1105                 1110             


Thr Asp  Ile Asp Glu Cys Arg  Ile Ser Pro Asp Leu  Cys Gly Ser 
    1115                 1120                 1125             


Gly Ile  Cys Val Asn Thr Pro  Gly Ser Phe Glu Cys  Glu Cys Phe 
    1130                 1135                 1140             


Glu Gly  Tyr Glu Ser Gly Phe  Met Met Met Lys Asn  Cys Met Asp 
    1145                 1150                 1155             


Ile Asp  Glu Cys Glu Arg Asn  Pro Leu Leu Cys Arg  Gly Gly Thr 
    1160                 1165                 1170             


Cys Val  Asn Thr Glu Gly Ser  Phe Gln Cys Asp Cys  Pro Leu Gly 
    1175                 1180                 1185             


His Glu  Leu Ser Pro Ser Arg  Glu Asp Cys Val Asp  Ile Asn Glu 
    1190                 1195                 1200             


Cys Ser  Leu Ser Asp Asn Leu  Cys Arg Asn Gly Lys  Cys Val Asn 
    1205                 1210                 1215             


Met Ile  Gly Thr Tyr Gln Cys  Ser Cys Asn Pro Gly  Tyr Gln Ala 
    1220                 1225                 1230             


Thr Pro  Asp Arg Gln Gly Cys  Thr Asp Ile Asp Glu  Cys Met Ile 
    1235                 1240                 1245             


Met Asn  Gly Gly Cys Asp Thr  Gln Cys Thr Asn Ser  Glu Gly Ser 
    1250                 1255                 1260             


Tyr Glu  Cys Ser Cys Ser Glu  Gly Tyr Ala Leu Met  Pro Asp Gly 
    1265                 1270                 1275             


Arg Ser  Cys Ala Asp Ile Asp  Glu Cys Glu Asn Asn  Pro Asp Ile 
    1280                 1285                 1290             


Cys Asp  Gly Gly Gln Cys Thr  Asn Ile Pro Gly Glu  Tyr Arg Cys 
    1295                 1300                 1305             


Leu Cys  Tyr Asp Gly Phe Met  Ala Ser Met Asp Met  Lys Thr Cys 
    1310                 1315                 1320             


Ile Asp  Val Asn Glu Cys Asp  Leu Asn Ser Asn Ile  Cys Met Phe 
    1325                 1330                 1335             


Gly Glu  Cys Glu Asn Thr Lys  Gly Ser Phe Ile Cys  His Cys Gln 
    1340                 1345                 1350             


Leu Gly  Tyr Ser Val Lys Lys  Gly Thr Thr Gly Cys  Thr Asp Val 
    1355                 1360                 1365             


Asp Glu  Cys Glu Ile Gly Ala  His Asn Cys Asp Met  His Ala Ser 
    1370                 1375                 1380             


Cys Leu  Asn Ile Pro Gly Ser  Phe Lys Cys Ser Cys  Arg Glu Gly 
    1385                 1390                 1395             


Trp Ile  Gly Asn Gly Ile Lys  Cys Ile Asp Leu Asp  Glu Cys Ser 
    1400                 1405                 1410             


Asn Gly  Thr His Gln Cys Ser  Ile Asn Ala Gln Cys  Val Asn Thr 
    1415                 1420                 1425             


Pro Gly  Ser Tyr Arg Cys Ala  Cys Ser Glu Gly Phe  Thr Gly Asp 
    1430                 1435                 1440             


Gly Phe  Thr Cys Ser Asp Val  Asp Glu Cys Ala Glu  Asn Ile Asn 
    1445                 1450                 1455             


Leu Cys  Glu Asn Gly Gln Cys  Leu Asn Val Pro Gly  Ala Tyr Arg 
    1460                 1465                 1470             


Cys Glu  Cys Glu Met Gly Phe  Thr Pro Ala Ser Asp  Ser Arg Ser 
    1475                 1480                 1485             


Cys Gln  Asp Ile Asp Glu Cys  Ser Phe Gln Asn Ile  Cys Val Phe 
    1490                 1495                 1500             


Gly Thr  Cys Asn Asn Leu Pro  Gly Met Phe His Cys  Ile Cys Asp 
    1505                 1510                 1515             


Asp Gly  Tyr Glu Leu Asp Arg  Thr Gly Gly Asn Cys  Thr Asp Ile 
    1520                 1525                 1530             


Asp Glu  Cys Ala Asp Pro Ile  Asn Cys Val Asn Gly  Leu Cys Val 
    1535                 1540                 1545             


Asn Thr  Pro Gly Arg Tyr Glu  Cys Asn Cys Pro Pro  Asp Phe Gln 
    1550                 1555                 1560             


Leu Asn  Pro Thr Gly Val Gly  Cys Val Asp Asn Arg  Val Gly Asn 
    1565                 1570                 1575             


Cys Tyr  Leu Lys Phe Gly Pro  Arg Gly Asp Gly Ser  Leu Ser Cys 
    1580                 1585                 1590             


Asn Thr  Glu Ile Gly Val Gly  Val Ser Arg Ser Ser  Cys Cys Cys 
    1595                 1600                 1605             


Ser Leu  Gly Lys Ala Trp Gly  Asn Pro Cys Glu Thr  Cys Pro Pro 
    1610                 1615                 1620             


Val Asn  Ser Thr Glu Tyr Tyr  Thr Leu Cys Pro Gly  Gly Glu Gly 
    1625                 1630                 1635             


Phe Arg  Pro Asn Pro Ile Thr  Ile Ile Leu Glu Asp  Ile Asp Glu 
    1640                 1645                 1650             


Cys Gln  Glu Leu Pro Gly Leu  Cys Gln Gly Gly Asn  Cys Ile Asn 
    1655                 1660                 1665             


Thr Phe  Gly Ser Phe Gln Cys  Glu Cys Pro Gln Gly  Tyr Tyr Leu 
    1670                 1675                 1680             


Ser Glu  Asp Thr Arg Ile Cys  Glu Asp Ile Asp Glu  Cys Phe Ala 
    1685                 1690                 1695             


His Pro  Gly Val Cys Gly Pro  Gly Thr Cys Tyr Asn  Thr Leu Gly 
    1700                 1705                 1710             


Asn Tyr  Thr Cys Ile Cys Pro  Pro Glu Tyr Met Gln  Val Asn Gly 
    1715                 1720                 1725             


Gly His  Asn Cys Met Asp Met  Arg Lys Ser Phe Cys  Tyr Arg Ser 
    1730                 1735                 1740             


Tyr Asn  Gly Thr Thr Cys Glu  Asn Glu Leu Pro Phe  Asn Val Thr 
    1745                 1750                 1755             


Lys Arg  Met Cys Cys Cys Thr  Tyr Asn Val Gly Lys  Ala Trp Asn 
    1760                 1765                 1770             


Lys Pro  Cys Glu Pro Cys Pro  Thr Pro Gly Thr Ala  Asp Phe Lys 
    1775                 1780                 1785             


Thr Ile  Cys Gly Asn Ile Pro  Gly Phe Thr Phe Asp  Ile His Thr 
    1790                 1795                 1800             


Gly Lys  Ala Val Asp Ile Asp  Glu Cys Lys Glu Ile  Pro Gly Ile 
    1805                 1810                 1815             


Cys Ala  Asn Gly Val Cys Ile  Asn Gln Ile Gly Ser  Phe Arg Cys 
    1820                 1825                 1830             


Glu Cys  Pro Thr Gly Phe Ser  Tyr Asn Asp Leu Leu  Leu Val Cys 
    1835                 1840                 1845             


Glu Asp  Ile Asp Glu Cys Ser  Asn Gly Asp Asn Leu  Cys Gln Arg 
    1850                 1855                 1860             


Asn Ala  Asp Cys Ile Asn Ser  Pro Gly Ser Tyr Arg  Cys Glu Cys 
    1865                 1870                 1875             


Ala Ala  Gly Phe Lys Leu Ser  Pro Asn Gly Ala Cys  Val Asp Arg 
    1880                 1885                 1890             


Asn Glu  Cys Leu Glu Ile Pro  Asn Val Cys Ser His  Gly Leu Cys 
    1895                 1900                 1905             


Val Asp  Leu Gln Gly Ser Tyr  Gln Cys Ile Cys His  Asn Gly Phe 
    1910                 1915                 1920             


Lys Ala  Ser Gln Asp Gln Thr  Met Cys Met Asp Val  Asp Glu Cys 
    1925                 1930                 1935             


Glu Arg  His Pro Cys Gly Asn  Gly Thr Cys Lys Asn  Thr Val Gly 
    1940                 1945                 1950             


Ser Tyr  Asn Cys Leu Cys Tyr  Pro Gly Phe Glu Leu  Thr His Asn 
    1955                 1960                 1965             


Asn Asp  Cys Leu Asp Ile Asp  Glu Cys Ser Ser Phe  Phe Gly Gln 
    1970                 1975                 1980             


Val Cys  Arg Asn Gly Arg Cys  Phe Asn Glu Ile Gly  Ser Phe Lys 
    1985                 1990                 1995             


Cys Leu  Cys Asn Glu Gly Tyr  Glu Leu Thr Pro Asp  Gly Lys Asn 
    2000                 2005                 2010             


Cys Ile  Asp Thr Asn Glu Cys  Val Ala Leu Pro Gly  Ser Cys Ser 
    2015                 2020                 2025             


Pro Gly  Thr Cys Gln Asn Leu  Glu Gly Ser Phe Arg  Cys Ile Cys 
    2030                 2035                 2040             


Pro Pro  Gly Tyr Glu Val Lys  Ser Glu Asn Cys Ile  Asp Ile Asn 
    2045                 2050                 2055             


Glu Cys  Asp Glu Asp Pro Asn  Ile Cys Leu Phe Gly  Ser Cys Thr 
    2060                 2065                 2070             


Asn Thr  Pro Gly Gly Phe Gln  Cys Leu Cys Pro Pro  Gly Phe Val 
    2075                 2080                 2085             


Leu Ser  Asp Asn Gly Arg Arg  Cys Phe Asp Thr Arg  Gln Ser Phe 
    2090                 2095                 2100             


Cys Phe  Thr Asn Phe Glu Asn  Gly Lys Cys Ser Val  Pro Lys Ala 
    2105                 2110                 2115             


Phe Asn  Thr Thr Lys Ala Lys  Cys Cys Cys Ser Lys  Met Pro Gly 
    2120                 2125                 2130             


Glu Gly  Trp Gly Asp Pro Cys  Glu Leu Cys Pro Lys  Asp Asp Glu 
    2135                 2140                 2145             


Val Ala  Phe Gln Asp Leu Cys  Pro Tyr Gly His Gly  Thr Val Pro 
    2150                 2155                 2160             


Ser Leu  His Asp Thr Arg Glu  Asp Val Asn Glu Cys  Leu Glu Ser 
    2165                 2170                 2175             


Pro Gly  Ile Cys Ser Asn Gly  Gln Cys Ile Asn Thr  Asp Gly Ser 
    2180                 2185                 2190             


Phe Arg  Cys Glu Cys Pro Met  Gly Tyr Asn Leu Asp  Tyr Thr Gly 
    2195                 2200                 2205             


Val Arg  Cys Val Asp Thr Asp  Glu Cys Ser Ile Gly  Asn Pro Cys 
    2210                 2215                 2220             


Gly Asn  Gly Thr Cys Thr Asn  Val Ile Gly Ser Phe  Glu Cys Asn 
    2225                 2230                 2235             


Cys Asn  Glu Gly Phe Glu Pro  Gly Pro Met Met Asn  Cys Glu Asp 
    2240                 2245                 2250             


Ile Asn  Glu Cys Ala Gln Asn  Pro Leu Leu Cys Ala  Phe Arg Cys 
    2255                 2260                 2265             


Met Asn  Thr Phe Gly Ser Tyr  Glu Cys Thr Cys Pro  Ile Gly Tyr 
    2270                 2275                 2280             


Ala Leu  Arg Glu Asp Gln Lys  Met Cys Lys Asp Leu  Asp Glu Cys 
    2285                 2290                 2295             


Ala Glu  Gly Leu His Asp Cys  Glu Ser Arg Gly Met  Met Cys Lys 
    2300                 2305                 2310             


Asn Leu  Ile Gly Thr Phe Met  Cys Ile Cys Pro Pro  Gly Met Ala 
    2315                 2320                 2325             


Arg Arg  Pro Asp Gly Glu Gly  Cys Val Asp Glu Asn  Glu Cys Arg 
    2330                 2335                 2340             


Thr Lys  Pro Gly Ile Cys Glu  Asn Gly Arg Cys Val  Asn Ile Ile 
    2345                 2350                 2355             


Gly Ser  Tyr Arg Cys Glu Cys  Asn Glu Gly Phe Gln  Ser Ser Ser 
    2360                 2365                 2370             


Ser Gly  Thr Glu Cys Leu Asp  Asn Arg Gln Gly Leu  Cys Phe Ala 
    2375                 2380                 2385             


Glu Val  Leu Gln Thr Ile Cys  Gln Met Ala Ser Ser  Ser Arg Asn 
    2390                 2395                 2400             


Leu Val  Thr Lys Ser Glu Cys  Cys Cys Asp Gly Gly  Arg Gly Trp 
    2405                 2410                 2415             


Gly His  Gln Cys Glu Leu Cys  Pro Leu Pro Gly Thr  Ala Gln Tyr 
    2420                 2425                 2430             


Lys Lys  Ile Cys Pro His Gly  Pro Gly Tyr Thr Thr  Asp Gly Arg 
    2435                 2440                 2445             


Asp Ile  Asp Glu Cys Lys Val  Met Pro Asn Leu Cys  Thr Asn Gly 
    2450                 2455                 2460             


Gln Cys  Ile Asn Thr Met Gly  Ser Phe Arg Cys Phe  Cys Lys Val 
    2465                 2470                 2475             


Gly Tyr  Thr Thr Asp Ile Ser  Gly Thr Ser Cys Ile  Asp Leu Asp 
    2480                 2485                 2490             


Glu Cys  Ser Gln Ser Pro Lys  Pro Cys Asn Tyr Ile  Cys Lys Asn 
    2495                 2500                 2505             


Thr Glu  Gly Ser Tyr Gln Cys  Ser Cys Pro Arg Gly  Tyr Val Leu 
    2510                 2515                 2520             


Gln Glu  Asp Gly Lys Thr Cys  Lys Asp Leu Asp Glu  Cys Gln Thr 
    2525                 2530                 2535             


Lys Gln  His Asn Cys Gln Phe  Leu Cys Val Asn Thr  Leu Gly Gly 
    2540                 2545                 2550             


Phe Thr  Cys Lys Cys Pro Pro  Gly Phe Thr Gln His  His Thr Ala 
    2555                 2560                 2565             


Cys Ile  Asp Asn Asn Glu Cys  Gly Ser Gln Pro Ser  Leu Cys Gly 
    2570                 2575                 2580             


Ala Lys  Gly Ile Cys Gln Asn  Thr Pro Gly Ser Phe  Ser Cys Glu 
    2585                 2590                 2595             


Cys Gln  Arg Gly Phe Ser Leu  Asp Ala Thr Gly Leu  Asn Cys Glu 
    2600                 2605                 2610             


Asp Val  Asp Glu Cys Asp Gly  Asn His Arg Cys Gln  His Gly Cys 
    2615                 2620                 2625             


Gln Asn  Ile Leu Gly Gly Tyr  Arg Cys Gly Cys Pro  Gln Gly Tyr 
    2630                 2635                 2640             


Ile Gln  His Tyr Gln Trp Asn  Gln Cys Val Asp Glu  Asn Glu Cys 
    2645                 2650                 2655             


Ser Asn  Pro Asn Ala Cys Gly  Ser Ala Ser Cys Tyr  Asn Thr Leu 
    2660                 2665                 2670             


Gly Ser  Tyr Lys Cys Ala Cys  Pro Ser Gly Phe Ser  Phe Asp Gln 
    2675                 2680                 2685             


Phe Ser  Ser Ala Cys His Asp  Val Asn Glu Cys Ser  Ser Ser Lys 
    2690                 2695                 2700             


Asn Pro  Cys Asn Tyr Gly Cys  Ser Asn Thr Glu Gly  Gly Tyr Leu 
    2705                 2710                 2715             


Cys Gly  Cys Pro Pro Gly Tyr  Tyr Arg Val Gly Gln  Gly His Cys 
    2720                 2725                 2730             


Val Ser  Gly Met Gly Phe Asn  Lys Gly Gln Tyr Leu  Ser Leu Asp 
    2735                 2740                 2745             


Thr Glu  Val Asp Glu Glu Asn  Ala Leu Ser Pro Glu  Ala Cys Tyr 
    2750                 2755                 2760             


Glu Cys  Lys Ile Asn Gly Tyr  Ser Lys Lys Asp Ser  Arg Gln Lys 
    2765                 2770                 2775             


Arg Ser  Ile His Glu Pro Asp  Pro Thr Ala Val Glu  Gln Ile Ser 
    2780                 2785                 2790             


Leu Glu  Ser Val Asp Met Asp  Ser Pro Val Asn Met  Lys Phe Asn 
    2795                 2800                 2805             


Leu Ser  His Leu Gly Ser Lys  Glu His Ile Leu Glu  Leu Arg Pro 
    2810                 2815                 2820             


Ala Ile  Gln Pro Leu Asn Asn  His Ile Arg Tyr Val  Ile Ser Gln 
    2825                 2830                 2835             


Gly Asn  Asp Asp Ser Val Phe  Arg Ile His Gln Arg  Asn Gly Leu 
    2840                 2845                 2850             


Ser Tyr  Leu His Thr Ala Lys  Lys Lys Leu Met Pro  Gly Thr Tyr 
    2855                 2860                 2865             


Thr Leu  Glu Ile Thr Ser Ile  Pro Leu Tyr Lys Lys  Lys Glu Leu 
    2870                 2875                 2880             


Lys Lys  Leu Glu Glu Ser Asn  Glu Asp Asp Tyr Leu  Leu Gly Glu 
    2885                 2890                 2895             


Leu Gly  Glu Ala Leu Arg Met  Arg Leu Gln Ile Gln  Leu Tyr 
    2900                 2905                 2910         


<210>  5158
<211>  341
<212>  PRT
<213>  Homo Sapiens

<400>  5158

Met Gly Arg Arg Arg Arg Leu Cys Leu Gln Leu Tyr Phe Leu Trp Leu 
1               5                   10                  15      


Gly Cys Val Val Leu Trp Ala Gln Gly Thr Ala Gly Gln Pro Gln Pro 
            20                  25                  30          


Pro Pro Pro Lys Pro Pro Arg Pro Gln Pro Pro Pro Gln Gln Val Arg 
        35                  40                  45              


Ser Ala Thr Ala Gly Ser Glu Gly Gly Phe Leu Ala Pro Glu Tyr Arg 
    50                  55                  60                  


Glu Glu Gly Ala Ala Val Ala Ser Arg Val Arg Arg Arg Gly Gln Gln 
65                  70                  75                  80  


Asp Val Leu Arg Gly Pro Asn Val Cys Gly Ser Arg Phe His Ser Tyr 
                85                  90                  95      


Cys Cys Pro Gly Trp Lys Thr Leu Pro Gly Gly Asn Gln Cys Ile Val 
            100                 105                 110         


Pro Ile Cys Arg Asn Ser Cys Gly Asp Gly Phe Cys Ser Arg Pro Asn 
        115                 120                 125             


Met Cys Thr Cys Ser Ser Gly Gln Ile Ser Ser Thr Cys Gly Ser Lys 
    130                 135                 140                 


Ser Ile Gln Gln Cys Ser Val Arg Cys Met Asn Gly Gly Thr Cys Ala 
145                 150                 155                 160 


Asp Asp His Cys Gln Cys Gln Lys Gly Tyr Ile Gly Thr Tyr Cys Gly 
                165                 170                 175     


Gln Pro Val Cys Glu Asn Gly Cys Gln Asn Gly Gly Arg Cys Ile Gly 
            180                 185                 190         


Pro Asn Arg Cys Ala Cys Val Tyr Gly Phe Thr Gly Pro Gln Cys Glu 
        195                 200                 205             


Arg Asp Tyr Arg Thr Gly Pro Cys Phe Thr Gln Val Asn Asn Gln Met 
    210                 215                 220                 


Cys Gln Gly Gln Leu Thr Gly Ile Val Cys Thr Lys Thr Leu Cys Cys 
225                 230                 235                 240 


Ala Thr Ile Gly Arg Ala Trp Gly His Pro Cys Glu Met Cys Pro Ala 
                245                 250                 255     


Gln Pro Gln Pro Cys Arg Arg Gly Phe Ile Pro Asn Ile Arg Thr Gly 
            260                 265                 270         


Ala Cys Gln Asp Val Asp Glu Cys Gln Ala Ile Pro Gly Ile Cys Gln 
        275                 280                 285             


Gly Gly Asn Cys Ile Asn Thr Val Gly Ser Phe Glu Cys Arg Cys Pro 
    290                 295                 300                 


Ala Gly His Lys Gln Ser Glu Thr Thr Gln Lys Cys Glu Val His Val 
305                 310                 315                 320 


Asp Lys Ala Gln Ala Gly Ala Arg Cys Pro Cys Val Ile Leu Pro Ser 
                325                 330                 335     


Arg Leu Tyr Leu Arg 
            340     


<210>  5159
<211>  2912
<212>  PRT
<213>  Homo Sapiens

<400>  5159

Met Gly Arg Arg Arg Arg Leu Cys Leu Gln Leu Tyr Phe Leu Trp Leu 
1               5                   10                  15      


Gly Cys Val Val Leu Trp Ala Gln Gly Thr Ala Gly Gln Pro Gln Pro 
            20                  25                  30          


Pro Pro Pro Lys Pro Pro Arg Pro Gln Pro Pro Pro Gln Gln Val Arg 
        35                  40                  45              


Ser Ala Thr Ala Gly Ser Glu Gly Gly Phe Leu Ala Pro Glu Tyr Arg 
    50                  55                  60                  


Glu Glu Gly Ala Ala Val Ala Ser Arg Val Arg Arg Arg Gly Gln Gln 
65                  70                  75                  80  


Asp Val Leu Arg Gly Pro Asn Val Cys Gly Ser Arg Phe His Ser Tyr 
                85                  90                  95      


Cys Cys Pro Gly Trp Lys Thr Leu Pro Gly Gly Asn Gln Cys Ile Val 
            100                 105                 110         


Pro Ile Cys Arg Asn Ser Cys Gly Asp Gly Phe Cys Ser Arg Pro Asn 
        115                 120                 125             


Met Cys Thr Cys Ser Ser Gly Gln Ile Ser Ser Thr Cys Gly Ser Lys 
    130                 135                 140                 


Ser Ile Gln Gln Cys Ser Val Arg Cys Met Asn Gly Gly Thr Cys Ala 
145                 150                 155                 160 


Asp Asp His Cys Gln Cys Gln Lys Gly Tyr Ile Gly Thr Tyr Cys Gly 
                165                 170                 175     


Gln Pro Val Cys Glu Asn Gly Cys Gln Asn Gly Gly Arg Cys Ile Gly 
            180                 185                 190         


Pro Asn Arg Cys Ala Cys Val Tyr Gly Phe Thr Gly Pro Gln Cys Glu 
        195                 200                 205             


Arg Asp Tyr Arg Thr Gly Pro Cys Phe Thr Gln Val Asn Asn Gln Met 
    210                 215                 220                 


Cys Gln Gly Gln Leu Thr Gly Ile Val Cys Thr Lys Thr Leu Cys Cys 
225                 230                 235                 240 


Ala Thr Ile Gly Arg Ala Trp Gly His Pro Cys Glu Met Cys Pro Ala 
                245                 250                 255     


Gln Pro Gln Pro Cys Arg Arg Gly Phe Ile Pro Asn Ile Arg Thr Gly 
            260                 265                 270         


Ala Cys Gln Asp Val Asp Glu Cys Gln Ala Ile Pro Gly Ile Cys Gln 
        275                 280                 285             


Gly Gly Asn Cys Ile Asn Thr Val Gly Ser Phe Glu Cys Arg Cys Pro 
    290                 295                 300                 


Ala Gly His Lys Gln Ser Glu Thr Thr Gln Lys Cys Glu Asp Ile Asp 
305                 310                 315                 320 


Glu Cys Ser Ile Ile Pro Gly Ile Cys Glu Thr Gly Glu Cys Ser Asn 
                325                 330                 335     


Thr Val Gly Ser Tyr Phe Cys Val Cys Pro Arg Gly Tyr Val Thr Ser 
            340                 345                 350         


Thr Asp Gly Ser Arg Cys Ile Asp Gln Arg Thr Gly Met Cys Phe Ser 
        355                 360                 365             


Gly Leu Val Asn Gly Arg Cys Ala Gln Glu Leu Pro Gly Arg Met Thr 
    370                 375                 380                 


Lys Met Gln Cys Cys Cys Glu Pro Gly Arg Cys Trp Gly Ile Gly Thr 
385                 390                 395                 400 


Ile Pro Glu Ala Cys Pro Val Arg Gly Ser Glu Glu Tyr Arg Arg Leu 
                405                 410                 415     


Cys Met Asp Gly Leu Pro Met Gly Gly Ile Pro Gly Ser Ala Gly Ser 
            420                 425                 430         


Arg Pro Gly Gly Thr Gly Gly Asn Gly Phe Ala Pro Ser Gly Asn Gly 
        435                 440                 445             


Asn Gly Tyr Gly Pro Gly Gly Thr Gly Phe Ile Pro Ile Pro Gly Gly 
    450                 455                 460                 


Asn Gly Phe Ser Pro Gly Val Gly Gly Ala Gly Val Gly Ala Gly Gly 
465                 470                 475                 480 


Gln Gly Pro Ile Ile Thr Gly Leu Thr Ile Leu Asn Gln Thr Ile Asp 
                485                 490                 495     


Ile Cys Lys His His Ala Asn Leu Cys Leu Asn Gly Arg Cys Ile Pro 
            500                 505                 510         


Thr Val Ser Ser Tyr Arg Cys Glu Cys Asn Met Gly Tyr Lys Gln Asp 
        515                 520                 525             


Ala Asn Gly Asp Cys Ile Asp Val Asp Glu Cys Thr Ser Asn Pro Cys 
    530                 535                 540                 


Thr Asn Gly Asp Cys Val Asn Thr Pro Gly Ser Tyr Tyr Cys Lys Cys 
545                 550                 555                 560 


His Ala Gly Phe Gln Arg Thr Pro Thr Lys Gln Ala Cys Ile Asp Ile 
                565                 570                 575     


Asp Glu Cys Ile Gln Asn Gly Val Leu Cys Lys Asn Gly Arg Cys Val 
            580                 585                 590         


Asn Thr Asp Gly Ser Phe Gln Cys Ile Cys Asn Ala Gly Phe Glu Leu 
        595                 600                 605             


Thr Thr Asp Gly Lys Asn Cys Val Asp His Asp Glu Cys Thr Thr Thr 
    610                 615                 620                 


Asn Met Cys Leu Asn Gly Met Cys Ile Asn Glu Asp Gly Ser Phe Lys 
625                 630                 635                 640 


Cys Ile Cys Lys Pro Gly Phe Val Leu Ala Pro Asn Gly Arg Tyr Cys 
                645                 650                 655     


Thr Asp Val Asp Glu Cys Gln Thr Pro Gly Ile Cys Met Asn Gly His 
            660                 665                 670         


Cys Ile Asn Ser Glu Gly Ser Phe Arg Cys Asp Cys Pro Pro Gly Leu 
        675                 680                 685             


Ala Val Gly Met Asp Gly Arg Val Cys Val Asp Thr His Met Arg Ser 
    690                 695                 700                 


Thr Cys Tyr Gly Gly Ile Lys Lys Gly Val Cys Val Arg Pro Phe Pro 
705                 710                 715                 720 


Gly Ala Val Thr Lys Ser Glu Cys Cys Cys Ala Asn Pro Asp Tyr Gly 
                725                 730                 735     


Phe Gly Glu Pro Cys Gln Pro Cys Pro Ala Lys Asn Ser Ala Glu Phe 
            740                 745                 750         


His Gly Leu Cys Ser Ser Gly Val Gly Ile Thr Val Asp Gly Arg Asp 
        755                 760                 765             


Ile Asn Glu Cys Ala Leu Asp Pro Asp Ile Cys Ala Asn Gly Ile Cys 
    770                 775                 780                 


Glu Asn Leu Arg Gly Ser Tyr Arg Cys Asn Cys Asn Ser Gly Tyr Glu 
785                 790                 795                 800 


Pro Asp Ala Ser Gly Arg Asn Cys Ile Asp Ile Asp Glu Cys Leu Val 
                805                 810                 815     


Asn Arg Leu Leu Cys Asp Asn Gly Leu Cys Arg Asn Thr Pro Gly Ser 
            820                 825                 830         


Tyr Ser Cys Thr Cys Pro Pro Gly Tyr Val Phe Arg Thr Glu Thr Glu 
        835                 840                 845             


Thr Cys Glu Asp Ile Asn Glu Cys Glu Ser Asn Pro Cys Val Asn Gly 
    850                 855                 860                 


Ala Cys Arg Asn Asn Leu Gly Ser Phe Asn Cys Glu Cys Ser Pro Gly 
865                 870                 875                 880 


Ser Lys Leu Ser Ser Thr Gly Leu Ile Cys Ile Asp Ser Leu Lys Gly 
                885                 890                 895     


Thr Cys Trp Leu Asn Ile Gln Asp Ser Arg Cys Glu Val Asn Ile Asn 
            900                 905                 910         


Gly Ala Thr Leu Lys Ser Glu Cys Cys Ala Thr Leu Gly Ala Ala Trp 
        915                 920                 925             


Gly Ser Pro Cys Glu Arg Cys Glu Leu Asp Thr Ala Cys Pro Arg Gly 
    930                 935                 940                 


Leu Ala Arg Ile Lys Gly Val Thr Cys Glu Asp Val Asn Glu Cys Glu 
945                 950                 955                 960 


Val Phe Pro Gly Val Cys Pro Asn Gly Arg Cys Val Asn Ser Lys Gly 
                965                 970                 975     


Ser Phe His Cys Glu Cys Pro Glu Gly Leu Thr Leu Asp Gly Thr Gly 
            980                 985                 990         


Arg Val Cys Leu Asp Ile Arg Met  Glu Gln Cys Tyr Leu  Lys Trp Asp 
        995                 1000                 1005             


Glu Asp  Glu Cys Ile His Pro  Val Pro Gly Lys Phe  Arg Met Asp 
    1010                 1015                 1020             


Ala Cys  Cys Cys Ala Val Gly  Ala Ala Trp Gly Thr  Glu Cys Glu 
    1025                 1030                 1035             


Glu Cys  Pro Lys Pro Gly Thr  Lys Glu Tyr Glu Thr  Leu Cys Pro 
    1040                 1045                 1050             


Arg Gly  Ala Gly Phe Ala Asn  Arg Gly Asp Val Leu  Thr Gly Arg 
    1055                 1060                 1065             


Pro Phe  Tyr Lys Asp Ile Asn  Glu Cys Lys Ala Phe  Pro Gly Met 
    1070                 1075                 1080             


Cys Thr  Tyr Gly Lys Cys Arg  Asn Thr Ile Gly Ser  Phe Lys Cys 
    1085                 1090                 1095             


Arg Cys  Asn Ser Gly Phe Ala  Leu Asp Met Glu Glu  Arg Asn Cys 
    1100                 1105                 1110             


Thr Asp  Ile Asp Glu Cys Arg  Ile Ser Pro Asp Leu  Cys Gly Ser 
    1115                 1120                 1125             


Gly Ile  Cys Val Asn Thr Pro  Gly Ser Phe Glu Cys  Glu Cys Phe 
    1130                 1135                 1140             


Glu Gly  Tyr Glu Ser Gly Phe  Met Met Met Lys Asn  Cys Met Asp 
    1145                 1150                 1155             


Ile Asp  Glu Cys Glu Arg Asn  Pro Leu Leu Cys Arg  Gly Gly Thr 
    1160                 1165                 1170             


Cys Val  Asn Thr Glu Gly Ser  Phe Gln Cys Asp Cys  Pro Leu Gly 
    1175                 1180                 1185             


His Glu  Leu Ser Pro Ser Arg  Glu Asp Cys Val Asp  Ile Asn Glu 
    1190                 1195                 1200             


Cys Ser  Leu Ser Asp Asn Leu  Cys Arg Asn Gly Lys  Cys Val Asn 
    1205                 1210                 1215             


Met Ile  Gly Thr Tyr Gln Cys  Ser Cys Asn Pro Gly  Tyr Gln Ala 
    1220                 1225                 1230             


Thr Pro  Asp Arg Gln Gly Cys  Thr Asp Ile Asp Glu  Cys Met Ile 
    1235                 1240                 1245             


Met Asn  Gly Gly Cys Asp Thr  Gln Cys Thr Asn Ser  Glu Gly Ser 
    1250                 1255                 1260             


Tyr Glu  Cys Ser Cys Ser Glu  Gly Tyr Ala Leu Met  Pro Asp Gly 
    1265                 1270                 1275             


Arg Ser  Cys Ala Asp Ile Asp  Glu Cys Glu Asn Asn  Pro Asp Ile 
    1280                 1285                 1290             


Cys Asp  Gly Gly Gln Cys Thr  Asn Ile Pro Gly Glu  Tyr Arg Cys 
    1295                 1300                 1305             


Leu Cys  Tyr Asp Gly Phe Met  Ala Ser Met Asp Met  Lys Thr Cys 
    1310                 1315                 1320             


Ile Asp  Val Asn Glu Cys Asp  Leu Asn Ser Asn Ile  Cys Met Phe 
    1325                 1330                 1335             


Gly Glu  Cys Glu Asn Thr Lys  Gly Ser Phe Ile Cys  His Cys Gln 
    1340                 1345                 1350             


Leu Gly  Tyr Ser Val Lys Lys  Gly Thr Thr Gly Cys  Thr Asp Val 
    1355                 1360                 1365             


Asp Glu  Cys Glu Ile Gly Ala  His Asn Cys Asp Met  His Ala Ser 
    1370                 1375                 1380             


Cys Leu  Asn Ile Pro Gly Ser  Phe Lys Cys Ser Cys  Arg Glu Gly 
    1385                 1390                 1395             


Trp Ile  Gly Asn Gly Ile Lys  Cys Ile Asp Leu Asp  Glu Cys Ser 
    1400                 1405                 1410             


Asn Gly  Thr His Gln Cys Ser  Ile Asn Ala Gln Cys  Val Asn Thr 
    1415                 1420                 1425             


Pro Gly  Ser Tyr Arg Cys Ala  Cys Ser Glu Gly Phe  Thr Gly Asp 
    1430                 1435                 1440             


Gly Phe  Thr Cys Ser Asp Val  Asp Glu Cys Ala Glu  Asn Ile Asn 
    1445                 1450                 1455             


Leu Cys  Glu Asn Gly Gln Cys  Leu Asn Val Pro Gly  Ala Tyr Arg 
    1460                 1465                 1470             


Cys Glu  Cys Glu Met Gly Phe  Thr Pro Ala Ser Asp  Ser Arg Ser 
    1475                 1480                 1485             


Cys Gln  Asp Ile Asp Glu Cys  Ser Phe Gln Asn Ile  Cys Val Phe 
    1490                 1495                 1500             


Gly Thr  Cys Asn Asn Leu Pro  Gly Met Phe His Cys  Ile Cys Asp 
    1505                 1510                 1515             


Asp Gly  Tyr Glu Leu Asp Arg  Thr Gly Gly Asn Cys  Thr Asp Ile 
    1520                 1525                 1530             


Asp Glu  Cys Ala Asp Pro Ile  Asn Cys Val Asn Gly  Leu Cys Val 
    1535                 1540                 1545             


Asn Thr  Pro Gly Arg Tyr Glu  Cys Asn Cys Pro Pro  Asp Phe Gln 
    1550                 1555                 1560             


Leu Asn  Pro Thr Gly Val Gly  Cys Val Asp Asn Arg  Val Gly Asn 
    1565                 1570                 1575             


Cys Tyr  Leu Lys Phe Gly Pro  Arg Gly Asp Gly Ser  Leu Ser Cys 
    1580                 1585                 1590             


Asn Thr  Glu Ile Gly Val Gly  Val Ser Arg Ser Ser  Cys Cys Cys 
    1595                 1600                 1605             


Ser Leu  Gly Lys Ala Trp Gly  Asn Pro Cys Glu Thr  Cys Pro Pro 
    1610                 1615                 1620             


Val Asn  Ser Thr Glu Tyr Tyr  Thr Leu Cys Pro Gly  Gly Glu Gly 
    1625                 1630                 1635             


Phe Arg  Pro Asn Pro Ile Thr  Ile Ile Leu Glu Asp  Ile Asp Glu 
    1640                 1645                 1650             


Cys Gln  Glu Leu Pro Gly Leu  Cys Gln Gly Gly Asn  Cys Ile Asn 
    1655                 1660                 1665             


Thr Phe  Gly Ser Phe Gln Cys  Glu Cys Pro Gln Gly  Tyr Tyr Leu 
    1670                 1675                 1680             


Ser Glu  Asp Thr Arg Ile Cys  Glu Asp Ile Asp Glu  Cys Phe Ala 
    1685                 1690                 1695             


His Pro  Gly Val Cys Gly Pro  Gly Thr Cys Tyr Asn  Thr Leu Gly 
    1700                 1705                 1710             


Asn Tyr  Thr Cys Ile Cys Pro  Pro Glu Tyr Met Gln  Val Asn Gly 
    1715                 1720                 1725             


Gly His  Asn Cys Met Asp Met  Arg Lys Ser Phe Cys  Tyr Arg Ser 
    1730                 1735                 1740             


Tyr Asn  Gly Thr Thr Cys Glu  Asn Glu Leu Pro Phe  Asn Val Thr 
    1745                 1750                 1755             


Lys Arg  Met Cys Cys Cys Thr  Tyr Asn Val Gly Lys  Ala Trp Asn 
    1760                 1765                 1770             


Lys Pro  Cys Glu Pro Cys Pro  Thr Pro Gly Thr Ala  Asp Phe Lys 
    1775                 1780                 1785             


Thr Ile  Cys Gly Asn Ile Pro  Gly Phe Thr Phe Asp  Ile His Thr 
    1790                 1795                 1800             


Gly Lys  Ala Val Asp Ile Asp  Glu Cys Lys Glu Ile  Pro Gly Ile 
    1805                 1810                 1815             


Cys Ala  Asn Gly Val Cys Ile  Asn Gln Ile Gly Ser  Phe Arg Cys 
    1820                 1825                 1830             


Glu Cys  Pro Thr Gly Phe Ser  Tyr Asn Asp Leu Leu  Leu Val Cys 
    1835                 1840                 1845             


Glu Asp  Ile Asp Glu Cys Ser  Asn Gly Asp Asn Leu  Cys Gln Arg 
    1850                 1855                 1860             


Asn Ala  Asp Cys Ile Asn Ser  Pro Gly Ser Tyr Arg  Cys Glu Cys 
    1865                 1870                 1875             


Ala Ala  Gly Phe Lys Leu Ser  Pro Asn Gly Ala Cys  Val Asp Arg 
    1880                 1885                 1890             


Asn Glu  Cys Leu Glu Ile Pro  Asn Val Cys Ser His  Gly Leu Cys 
    1895                 1900                 1905             


Val Asp  Leu Gln Gly Ser Tyr  Gln Cys Ile Cys His  Asn Gly Phe 
    1910                 1915                 1920             


Lys Ala  Ser Gln Asp Gln Thr  Met Cys Met Asp Val  Asp Glu Cys 
    1925                 1930                 1935             


Glu Arg  His Pro Cys Gly Asn  Gly Thr Cys Lys Asn  Thr Val Gly 
    1940                 1945                 1950             


Ser Tyr  Asn Cys Leu Cys Tyr  Pro Gly Phe Glu Leu  Thr His Asn 
    1955                 1960                 1965             


Asn Asp  Cys Leu Asp Ile Asp  Glu Cys Ser Ser Phe  Phe Gly Gln 
    1970                 1975                 1980             


Val Cys  Arg Asn Gly Arg Cys  Phe Asn Glu Ile Gly  Ser Phe Lys 
    1985                 1990                 1995             


Cys Leu  Cys Asn Glu Gly Tyr  Glu Leu Thr Pro Asp  Gly Lys Asn 
    2000                 2005                 2010             


Cys Ile  Asp Thr Asn Glu Cys  Val Ala Leu Pro Gly  Ser Cys Ser 
    2015                 2020                 2025             


Pro Gly  Thr Cys Gln Asn Leu  Glu Gly Ser Phe Arg  Cys Ile Cys 
    2030                 2035                 2040             


Pro Pro  Gly Tyr Glu Val Lys  Ser Glu Asn Cys Ile  Asp Ile Asn 
    2045                 2050                 2055             


Glu Cys  Asp Glu Asp Pro Asn  Ile Cys Leu Phe Gly  Ser Cys Thr 
    2060                 2065                 2070             


Asn Thr  Pro Gly Gly Phe Gln  Cys Leu Cys Pro Pro  Gly Phe Val 
    2075                 2080                 2085             


Leu Ser  Asp Asn Gly Arg Arg  Cys Phe Asp Thr Arg  Gln Ser Phe 
    2090                 2095                 2100             


Cys Phe  Thr Asn Phe Glu Asn  Gly Lys Cys Ser Val  Pro Lys Ala 
    2105                 2110                 2115             


Phe Asn  Thr Thr Lys Ala Lys  Cys Cys Cys Ser Lys  Met Pro Gly 
    2120                 2125                 2130             


Glu Gly  Trp Gly Asp Pro Cys  Glu Leu Cys Pro Lys  Asp Asp Glu 
    2135                 2140                 2145             


Val Ala  Phe Gln Asp Leu Cys  Pro Tyr Gly His Gly  Thr Val Pro 
    2150                 2155                 2160             


Ser Leu  His Asp Thr Arg Glu  Asp Val Asn Glu Cys  Leu Glu Ser 
    2165                 2170                 2175             


Pro Gly  Ile Cys Ser Asn Gly  Gln Cys Ile Asn Thr  Asp Gly Ser 
    2180                 2185                 2190             


Phe Arg  Cys Glu Cys Pro Met  Gly Tyr Asn Leu Asp  Tyr Thr Gly 
    2195                 2200                 2205             


Val Arg  Cys Val Asp Thr Asp  Glu Cys Ser Ile Gly  Asn Pro Cys 
    2210                 2215                 2220             


Gly Asn  Gly Thr Cys Thr Asn  Val Ile Gly Ser Phe  Glu Cys Asn 
    2225                 2230                 2235             


Cys Asn  Glu Gly Phe Glu Pro  Gly Pro Met Met Asn  Cys Glu Asp 
    2240                 2245                 2250             


Ile Asn  Glu Cys Ala Gln Asn  Pro Leu Leu Cys Ala  Phe Arg Cys 
    2255                 2260                 2265             


Met Asn  Thr Phe Gly Ser Tyr  Glu Cys Thr Cys Pro  Ile Gly Tyr 
    2270                 2275                 2280             


Ala Leu  Arg Glu Asp Gln Lys  Met Cys Lys Asp Leu  Asp Glu Cys 
    2285                 2290                 2295             


Ala Glu  Gly Leu His Asp Cys  Glu Ser Arg Gly Met  Met Cys Lys 
    2300                 2305                 2310             


Asn Leu  Ile Gly Thr Phe Met  Cys Ile Cys Pro Pro  Gly Met Ala 
    2315                 2320                 2325             


Arg Arg  Pro Asp Gly Glu Gly  Cys Val Asp Glu Asn  Glu Cys Arg 
    2330                 2335                 2340             


Thr Lys  Pro Gly Ile Cys Glu  Asn Gly Arg Cys Val  Asn Ile Ile 
    2345                 2350                 2355             


Gly Ser  Tyr Arg Cys Glu Cys  Asn Glu Gly Phe Gln  Ser Ser Ser 
    2360                 2365                 2370             


Ser Gly  Thr Glu Cys Leu Asp  Asn Arg Gln Gly Leu  Cys Phe Ala 
    2375                 2380                 2385             


Glu Val  Leu Gln Thr Ile Cys  Gln Met Ala Ser Ser  Ser Arg Asn 
    2390                 2395                 2400             


Leu Val  Thr Lys Ser Glu Cys  Cys Cys Asp Gly Gly  Arg Gly Trp 
    2405                 2410                 2415             


Gly His  Gln Cys Glu Leu Cys  Pro Leu Pro Gly Thr  Ala Gln Tyr 
    2420                 2425                 2430             


Lys Lys  Ile Cys Pro His Gly  Pro Gly Tyr Thr Thr  Asp Gly Arg 
    2435                 2440                 2445             


Asp Ile  Asp Glu Cys Lys Val  Met Pro Asn Leu Cys  Thr Asn Gly 
    2450                 2455                 2460             


Gln Cys  Ile Asn Thr Met Gly  Ser Phe Arg Cys Phe  Cys Lys Val 
    2465                 2470                 2475             


Gly Tyr  Thr Thr Asp Ile Ser  Gly Thr Ser Cys Ile  Asp Leu Asp 
    2480                 2485                 2490             


Glu Cys  Ser Gln Ser Pro Lys  Pro Cys Asn Tyr Ile  Cys Lys Asn 
    2495                 2500                 2505             


Thr Glu  Gly Ser Tyr Gln Cys  Ser Cys Pro Arg Gly  Tyr Val Leu 
    2510                 2515                 2520             


Gln Glu  Asp Gly Lys Thr Cys  Lys Asp Leu Asp Glu  Cys Gln Thr 
    2525                 2530                 2535             


Lys Gln  His Asn Cys Gln Phe  Leu Cys Val Asn Thr  Leu Gly Gly 
    2540                 2545                 2550             


Phe Thr  Cys Lys Cys Pro Pro  Gly Phe Thr Gln His  His Thr Ala 
    2555                 2560                 2565             


Cys Ile  Asp Asn Asn Glu Cys  Gly Ser Gln Pro Ser  Leu Cys Gly 
    2570                 2575                 2580             


Ala Lys  Gly Ile Cys Gln Asn  Thr Pro Gly Ser Phe  Ser Cys Glu 
    2585                 2590                 2595             


Cys Gln  Arg Gly Phe Ser Leu  Asp Ala Thr Gly Leu  Asn Cys Glu 
    2600                 2605                 2610             


Asp Val  Asp Glu Cys Asp Gly  Asn His Arg Cys Gln  His Gly Cys 
    2615                 2620                 2625             


Gln Asn  Ile Leu Gly Gly Tyr  Arg Cys Gly Cys Pro  Gln Gly Tyr 
    2630                 2635                 2640             


Ile Gln  His Tyr Gln Trp Asn  Gln Cys Val Asp Glu  Asn Glu Cys 
    2645                 2650                 2655             


Ser Asn  Pro Asn Ala Cys Gly  Ser Ala Ser Cys Tyr  Asn Thr Leu 
    2660                 2665                 2670             


Gly Ser  Tyr Lys Cys Ala Cys  Pro Ser Gly Phe Ser  Phe Asp Gln 
    2675                 2680                 2685             


Phe Ser  Ser Ala Cys His Asp  Val Asn Glu Cys Ser  Ser Ser Lys 
    2690                 2695                 2700             


Asn Pro  Cys Asn Tyr Gly Cys  Ser Asn Thr Glu Gly  Gly Tyr Leu 
    2705                 2710                 2715             


Cys Gly  Cys Pro Pro Gly Tyr  Tyr Arg Val Gly Gln  Gly His Cys 
    2720                 2725                 2730             


Val Ser  Gly Met Gly Phe Asn  Lys Gly Gln Tyr Leu  Ser Leu Asp 
    2735                 2740                 2745             


Thr Glu  Val Asp Glu Glu Asn  Ala Leu Ser Pro Glu  Ala Cys Tyr 
    2750                 2755                 2760             


Glu Cys  Lys Ile Asn Gly Tyr  Ser Lys Lys Asp Ser  Arg Gln Lys 
    2765                 2770                 2775             


Arg Ser  Ile His Glu Pro Asp  Pro Thr Ala Val Glu  Gln Ile Ser 
    2780                 2785                 2790             


Leu Glu  Ser Val Asp Met Asp  Ser Pro Val Asn Met  Lys Phe Asn 
    2795                 2800                 2805             


Leu Ser  His Leu Gly Ser Lys  Glu His Ile Leu Glu  Leu Arg Pro 
    2810                 2815                 2820             


Ala Ile  Gln Pro Leu Asn Asn  His Ile Arg Tyr Val  Ile Ser Gln 
    2825                 2830                 2835             


Gly Asn  Asp Asp Ser Val Phe  Arg Ile His Gln Arg  Asn Gly Leu 
    2840                 2845                 2850             


Ser Tyr  Leu His Thr Ala Lys  Lys Lys Leu Met Pro  Gly Thr Tyr 
    2855                 2860                 2865             


Thr Leu  Glu Ile Thr Ser Ile  Pro Leu Tyr Lys Lys  Lys Glu Leu 
    2870                 2875                 2880             


Lys Lys  Leu Glu Glu Ser Asn  Glu Asp Asp Tyr Leu  Leu Gly Glu 
    2885                 2890                 2895             


Leu Gly  Glu Ala Leu Arg Met  Arg Leu Gln Ile Gln  Leu Tyr 
    2900                 2905                 2910         


<210>  5160
<211>  2911
<212>  PRT
<213>  Homo Sapiens

<400>  5160

Met Gly Arg Arg Arg Arg Leu Cys Leu Gln Leu Tyr Phe Leu Trp Leu 
1               5                   10                  15      


Gly Cys Val Val Leu Trp Ala Gln Gly Thr Ala Gly Gln Pro Gln Pro 
            20                  25                  30          


Pro Pro Pro Lys Pro Pro Arg Pro Gln Pro Pro Pro Gln Gln Val Arg 
        35                  40                  45              


Ser Ala Thr Ala Gly Ser Glu Gly Gly Phe Leu Ala Pro Glu Tyr Arg 
    50                  55                  60                  


Glu Glu Gly Ala Ala Val Ala Ser Arg Val Arg Arg Arg Gly Gln Gln 
65                  70                  75                  80  


Asp Val Leu Arg Gly Pro Asn Val Cys Gly Ser Arg Phe His Ser Tyr 
                85                  90                  95      


Cys Cys Pro Gly Trp Lys Thr Leu Pro Gly Gly Asn Gln Cys Ile Val 
            100                 105                 110         


Pro Ile Cys Arg Asn Ser Cys Gly Asp Gly Phe Cys Ser Arg Pro Asn 
        115                 120                 125             


Met Cys Thr Cys Ser Ser Gly Gln Ile Ser Ser Thr Cys Gly Ser Lys 
    130                 135                 140                 


Ser Ile Gln Gln Cys Ser Val Arg Cys Met Asn Gly Gly Thr Cys Ala 
145                 150                 155                 160 


Asp Asp His Cys Gln Cys Gln Lys Gly Tyr Ile Gly Thr Tyr Cys Gly 
                165                 170                 175     


Gln Pro Val Cys Glu Asn Gly Cys Gln Asn Gly Gly Arg Cys Ile Thr 
            180                 185                 190         


Gln Pro Cys Ala Cys Val Tyr Gly Phe Thr Gly Pro Gln Cys Glu Arg 
        195                 200                 205             


Asp Tyr Arg Thr Gly Pro Cys Phe Thr Gln Val Asn Asn Gln Met Cys 
    210                 215                 220                 


Gln Gly Gln Leu Thr Gly Ile Val Cys Thr Lys Thr Leu Cys Cys Ala 
225                 230                 235                 240 


Thr Ile Gly Arg Ala Trp Gly His Pro Cys Glu Met Cys Pro Ala Gln 
                245                 250                 255     


Pro Gln Pro Cys Arg Arg Gly Phe Ile Pro Asn Ile Arg Thr Gly Ala 
            260                 265                 270         


Cys Gln Asp Val Asp Glu Cys Gln Ala Ile Pro Gly Ile Cys Gln Gly 
        275                 280                 285             


Gly Asn Cys Ile Asn Thr Val Gly Ser Phe Glu Cys Arg Cys Pro Ala 
    290                 295                 300                 


Gly His Lys Gln Ser Glu Thr Thr Gln Lys Cys Glu Asp Ile Asp Glu 
305                 310                 315                 320 


Cys Ser Ile Ile Pro Gly Ile Cys Glu Thr Gly Glu Cys Ser Asn Thr 
                325                 330                 335     


Val Gly Ser Tyr Phe Cys Val Cys Pro Arg Gly Tyr Val Thr Ser Thr 
            340                 345                 350         


Asp Gly Ser Arg Cys Ile Asp Gln Arg Thr Gly Met Cys Phe Ser Gly 
        355                 360                 365             


Leu Val Asn Gly Arg Cys Ala Gln Glu Leu Pro Gly Arg Met Thr Lys 
    370                 375                 380                 


Met Gln Cys Cys Cys Glu Pro Gly Arg Cys Trp Gly Ile Gly Thr Ile 
385                 390                 395                 400 


Pro Glu Ala Cys Pro Val Arg Gly Ser Glu Glu Tyr Arg Arg Leu Cys 
                405                 410                 415     


Met Asp Gly Leu Pro Met Gly Gly Ile Pro Gly Ser Ala Gly Ser Arg 
            420                 425                 430         


Pro Gly Gly Thr Gly Gly Asn Gly Phe Ala Pro Ser Gly Asn Gly Asn 
        435                 440                 445             


Gly Tyr Gly Pro Gly Gly Thr Gly Phe Ile Pro Ile Pro Gly Gly Asn 
    450                 455                 460                 


Gly Phe Ser Pro Gly Val Gly Gly Ala Gly Val Gly Ala Gly Gly Gln 
465                 470                 475                 480 


Gly Pro Ile Ile Thr Gly Leu Thr Ile Leu Asn Gln Thr Ile Asp Ile 
                485                 490                 495     


Cys Lys His His Ala Asn Leu Cys Leu Asn Gly Arg Cys Ile Pro Thr 
            500                 505                 510         


Val Ser Ser Tyr Arg Cys Glu Cys Asn Met Gly Tyr Lys Gln Asp Ala 
        515                 520                 525             


Asn Gly Asp Cys Ile Asp Val Asp Glu Cys Thr Ser Asn Pro Cys Thr 
    530                 535                 540                 


Asn Gly Asp Cys Val Asn Thr Pro Gly Ser Tyr Tyr Cys Lys Cys His 
545                 550                 555                 560 


Ala Gly Phe Gln Arg Thr Pro Thr Lys Gln Ala Cys Ile Asp Ile Asp 
                565                 570                 575     


Glu Cys Ile Gln Asn Gly Val Leu Cys Lys Asn Gly Arg Cys Val Asn 
            580                 585                 590         


Thr Asp Gly Ser Phe Gln Cys Ile Cys Asn Ala Gly Phe Glu Leu Thr 
        595                 600                 605             


Thr Asp Gly Lys Asn Cys Val Asp His Asp Glu Cys Thr Thr Thr Asn 
    610                 615                 620                 


Met Cys Leu Asn Gly Met Cys Ile Asn Glu Asp Gly Ser Phe Lys Cys 
625                 630                 635                 640 


Ile Cys Lys Pro Gly Phe Val Leu Ala Pro Asn Gly Arg Tyr Cys Thr 
                645                 650                 655     


Asp Val Asp Glu Cys Gln Thr Pro Gly Ile Cys Met Asn Gly His Cys 
            660                 665                 670         


Ile Asn Ser Glu Gly Ser Phe Arg Cys Asp Cys Pro Pro Gly Leu Ala 
        675                 680                 685             


Val Gly Met Asp Gly Arg Val Cys Val Asp Thr His Met Arg Ser Thr 
    690                 695                 700                 


Cys Tyr Gly Gly Ile Lys Lys Gly Val Cys Val Arg Pro Phe Pro Gly 
705                 710                 715                 720 


Ala Val Thr Lys Ser Glu Cys Cys Cys Ala Asn Pro Asp Tyr Gly Phe 
                725                 730                 735     


Gly Glu Pro Cys Gln Pro Cys Pro Ala Lys Asn Ser Ala Glu Phe His 
            740                 745                 750         


Gly Leu Cys Ser Ser Gly Val Gly Ile Thr Val Asp Gly Arg Asp Ile 
        755                 760                 765             


Asn Glu Cys Ala Leu Asp Pro Asp Ile Cys Ala Asn Gly Ile Cys Glu 
    770                 775                 780                 


Asn Leu Arg Gly Ser Tyr Arg Cys Asn Cys Asn Ser Gly Tyr Glu Pro 
785                 790                 795                 800 


Asp Ala Ser Gly Arg Asn Cys Ile Asp Ile Asp Glu Cys Leu Val Asn 
                805                 810                 815     


Arg Leu Leu Cys Asp Asn Gly Leu Cys Arg Asn Thr Pro Gly Ser Tyr 
            820                 825                 830         


Ser Cys Thr Cys Pro Pro Gly Tyr Val Phe Arg Thr Glu Thr Glu Thr 
        835                 840                 845             


Cys Glu Asp Ile Asn Glu Cys Glu Ser Asn Pro Cys Val Asn Gly Ala 
    850                 855                 860                 


Cys Arg Asn Asn Leu Gly Ser Phe Asn Cys Glu Cys Ser Pro Gly Ser 
865                 870                 875                 880 


Lys Leu Ser Ser Thr Gly Leu Ile Cys Ile Asp Ser Leu Lys Gly Thr 
                885                 890                 895     


Cys Trp Leu Asn Ile Gln Asp Ser Arg Cys Glu Val Asn Ile Asn Gly 
            900                 905                 910         


Ala Thr Leu Lys Ser Glu Cys Cys Ala Thr Leu Gly Ala Ala Trp Gly 
        915                 920                 925             


Ser Pro Cys Glu Arg Cys Glu Leu Asp Thr Ala Cys Pro Arg Gly Leu 
    930                 935                 940                 


Ala Arg Ile Lys Gly Val Thr Cys Glu Asp Val Asn Glu Cys Glu Val 
945                 950                 955                 960 


Phe Pro Gly Val Cys Pro Asn Gly Arg Cys Val Asn Ser Lys Gly Ser 
                965                 970                 975     


Phe His Cys Glu Cys Pro Glu Gly Leu Thr Leu Asp Gly Thr Gly Arg 
            980                 985                 990         


Val Cys Leu Asp Ile Arg Met Glu  Gln Cys Tyr Leu Lys  Trp Asp Glu 
        995                 1000                 1005             


Asp Glu  Cys Ile His Pro Val  Pro Gly Lys Phe Arg  Met Asp Ala 
    1010                 1015                 1020             


Cys Cys  Cys Ala Val Gly Ala  Ala Trp Gly Thr Glu  Cys Glu Glu 
    1025                 1030                 1035             


Cys Pro  Lys Pro Gly Thr Lys  Glu Tyr Glu Thr Leu  Cys Pro Arg 
    1040                 1045                 1050             


Gly Ala  Gly Phe Ala Asn Arg  Gly Asp Val Leu Thr  Gly Arg Pro 
    1055                 1060                 1065             


Phe Tyr  Lys Asp Ile Asn Glu  Cys Lys Ala Phe Pro  Gly Met Cys 
    1070                 1075                 1080             


Thr Tyr  Gly Lys Cys Arg Asn  Thr Ile Gly Ser Phe  Lys Cys Arg 
    1085                 1090                 1095             


Cys Asn  Ser Gly Phe Ala Leu  Asp Met Glu Glu Arg  Asn Cys Thr 
    1100                 1105                 1110             


Asp Ile  Asp Glu Cys Arg Ile  Ser Pro Asp Leu Cys  Gly Ser Gly 
    1115                 1120                 1125             


Ile Cys  Val Asn Thr Pro Gly  Ser Phe Glu Cys Glu  Cys Phe Glu 
    1130                 1135                 1140             


Gly Tyr  Glu Ser Gly Phe Met  Met Met Lys Asn Cys  Met Asp Ile 
    1145                 1150                 1155             


Asp Glu  Cys Glu Arg Asn Pro  Leu Leu Cys Arg Gly  Gly Thr Cys 
    1160                 1165                 1170             


Val Asn  Thr Glu Gly Ser Phe  Gln Cys Asp Cys Pro  Leu Gly His 
    1175                 1180                 1185             


Glu Leu  Ser Pro Ser Arg Glu  Asp Cys Val Asp Ile  Asn Glu Cys 
    1190                 1195                 1200             


Ser Leu  Ser Asp Asn Leu Cys  Arg Asn Gly Lys Cys  Val Asn Met 
    1205                 1210                 1215             


Ile Gly  Thr Tyr Gln Cys Ser  Cys Asn Pro Gly Tyr  Gln Ala Thr 
    1220                 1225                 1230             


Pro Asp  Arg Gln Gly Cys Thr  Asp Ile Asp Glu Cys  Met Ile Met 
    1235                 1240                 1245             


Asn Gly  Gly Cys Asp Thr Gln  Cys Thr Asn Ser Glu  Gly Ser Tyr 
    1250                 1255                 1260             


Glu Cys  Ser Cys Ser Glu Gly  Tyr Ala Leu Met Pro  Asp Gly Arg 
    1265                 1270                 1275             


Ser Cys  Ala Asp Ile Asp Glu  Cys Glu Asn Asn Pro  Asp Ile Cys 
    1280                 1285                 1290             


Asp Gly  Gly Gln Cys Thr Asn  Ile Pro Gly Glu Tyr  Arg Cys Leu 
    1295                 1300                 1305             


Cys Tyr  Asp Gly Phe Met Ala  Ser Met Asp Met Lys  Thr Cys Ile 
    1310                 1315                 1320             


Asp Val  Asn Glu Cys Asp Leu  Asn Ser Asn Ile Cys  Met Phe Gly 
    1325                 1330                 1335             


Glu Cys  Glu Asn Thr Lys Gly  Ser Phe Ile Cys His  Cys Gln Leu 
    1340                 1345                 1350             


Gly Tyr  Ser Val Lys Lys Gly  Thr Thr Gly Cys Thr  Asp Val Asp 
    1355                 1360                 1365             


Glu Cys  Glu Ile Gly Ala His  Asn Cys Asp Met His  Ala Ser Cys 
    1370                 1375                 1380             


Leu Asn  Ile Pro Gly Ser Phe  Lys Cys Ser Cys Arg  Glu Gly Trp 
    1385                 1390                 1395             


Ile Gly  Asn Gly Ile Lys Cys  Ile Asp Leu Asp Glu  Cys Ser Asn 
    1400                 1405                 1410             


Gly Thr  His Gln Cys Ser Ile  Asn Ala Gln Cys Val  Asn Thr Pro 
    1415                 1420                 1425             


Gly Ser  Tyr Arg Cys Ala Cys  Ser Glu Gly Phe Thr  Gly Asp Gly 
    1430                 1435                 1440             


Phe Thr  Cys Ser Asp Val Asp  Glu Cys Ala Glu Asn  Ile Asn Leu 
    1445                 1450                 1455             


Cys Glu  Asn Gly Gln Cys Leu  Asn Val Pro Gly Ala  Tyr Arg Cys 
    1460                 1465                 1470             


Glu Cys  Glu Met Gly Phe Thr  Pro Ala Ser Asp Ser  Arg Ser Cys 
    1475                 1480                 1485             


Gln Asp  Ile Asp Glu Cys Ser  Phe Gln Asn Ile Cys  Val Phe Gly 
    1490                 1495                 1500             


Thr Cys  Asn Asn Leu Pro Gly  Met Phe His Cys Ile  Cys Asp Asp 
    1505                 1510                 1515             


Gly Tyr  Glu Leu Asp Arg Thr  Gly Gly Asn Cys Thr  Asp Ile Asp 
    1520                 1525                 1530             


Glu Cys  Ala Asp Pro Ile Asn  Cys Val Asn Gly Leu  Cys Val Asn 
    1535                 1540                 1545             


Thr Pro  Gly Arg Tyr Glu Cys  Asn Cys Pro Pro Asp  Phe Gln Leu 
    1550                 1555                 1560             


Asn Pro  Thr Gly Val Gly Cys  Val Asp Asn Arg Val  Gly Asn Cys 
    1565                 1570                 1575             


Tyr Leu  Lys Phe Gly Pro Arg  Gly Asp Gly Ser Leu  Ser Cys Asn 
    1580                 1585                 1590             


Thr Glu  Ile Gly Val Gly Val  Ser Arg Ser Ser Cys  Cys Cys Ser 
    1595                 1600                 1605             


Leu Gly  Lys Ala Trp Gly Asn  Pro Cys Glu Thr Cys  Pro Pro Val 
    1610                 1615                 1620             


Asn Ser  Thr Glu Tyr Tyr Thr  Leu Cys Pro Gly Gly  Glu Gly Phe 
    1625                 1630                 1635             


Arg Pro  Asn Pro Ile Thr Ile  Ile Leu Glu Asp Ile  Asp Glu Cys 
    1640                 1645                 1650             


Gln Glu  Leu Pro Gly Leu Cys  Gln Gly Gly Asn Cys  Ile Asn Thr 
    1655                 1660                 1665             


Phe Gly  Ser Phe Gln Cys Glu  Cys Pro Gln Gly Tyr  Tyr Leu Ser 
    1670                 1675                 1680             


Glu Asp  Thr Arg Ile Cys Glu  Asp Ile Asp Glu Cys  Phe Ala His 
    1685                 1690                 1695             


Pro Gly  Val Cys Gly Pro Gly  Thr Cys Tyr Asn Thr  Leu Gly Asn 
    1700                 1705                 1710             


Tyr Thr  Cys Ile Cys Pro Pro  Glu Tyr Met Gln Val  Asn Gly Gly 
    1715                 1720                 1725             


His Asn  Cys Met Asp Met Arg  Lys Ser Phe Cys Tyr  Arg Ser Tyr 
    1730                 1735                 1740             


Asn Gly  Thr Thr Cys Glu Asn  Glu Leu Pro Phe Asn  Val Thr Lys 
    1745                 1750                 1755             


Arg Met  Cys Cys Cys Thr Tyr  Asn Val Gly Lys Ala  Trp Asn Lys 
    1760                 1765                 1770             


Pro Cys  Glu Pro Cys Pro Thr  Pro Gly Thr Ala Asp  Phe Lys Thr 
    1775                 1780                 1785             


Ile Cys  Gly Asn Ile Pro Gly  Phe Thr Phe Asp Ile  His Thr Gly 
    1790                 1795                 1800             


Lys Ala  Val Asp Ile Asp Glu  Cys Lys Glu Ile Pro  Gly Ile Cys 
    1805                 1810                 1815             


Ala Asn  Gly Val Cys Ile Asn  Gln Ile Gly Ser Phe  Arg Cys Glu 
    1820                 1825                 1830             


Cys Pro  Thr Gly Phe Ser Tyr  Asn Asp Leu Leu Leu  Val Cys Glu 
    1835                 1840                 1845             


Asp Ile  Asp Glu Cys Ser Asn  Gly Asp Asn Leu Cys  Gln Arg Asn 
    1850                 1855                 1860             


Ala Asp  Cys Ile Asn Ser Pro  Gly Ser Tyr Arg Cys  Glu Cys Ala 
    1865                 1870                 1875             


Ala Gly  Phe Lys Leu Ser Pro  Asn Gly Ala Cys Val  Asp Arg Asn 
    1880                 1885                 1890             


Glu Cys  Leu Glu Ile Pro Asn  Val Cys Ser His Gly  Leu Cys Val 
    1895                 1900                 1905             


Asp Leu  Gln Gly Ser Tyr Gln  Cys Ile Cys His Asn  Gly Phe Lys 
    1910                 1915                 1920             


Ala Ser  Gln Asp Gln Thr Met  Cys Met Asp Val Asp  Glu Cys Glu 
    1925                 1930                 1935             


Arg His  Pro Cys Gly Asn Gly  Thr Cys Lys Asn Thr  Val Gly Ser 
    1940                 1945                 1950             


Tyr Asn  Cys Leu Cys Tyr Pro  Gly Phe Glu Leu Thr  His Asn Asn 
    1955                 1960                 1965             


Asp Cys  Leu Asp Ile Asp Glu  Cys Ser Ser Phe Phe  Gly Gln Val 
    1970                 1975                 1980             


Cys Arg  Asn Gly Arg Cys Phe  Asn Glu Ile Gly Ser  Phe Lys Cys 
    1985                 1990                 1995             


Leu Cys  Asn Glu Gly Tyr Glu  Leu Thr Pro Asp Gly  Lys Asn Cys 
    2000                 2005                 2010             


Ile Asp  Thr Asn Glu Cys Val  Ala Leu Pro Gly Ser  Cys Ser Pro 
    2015                 2020                 2025             


Gly Thr  Cys Gln Asn Leu Glu  Gly Ser Phe Arg Cys  Ile Cys Pro 
    2030                 2035                 2040             


Pro Gly  Tyr Glu Val Lys Ser  Glu Asn Cys Ile Asp  Ile Asn Glu 
    2045                 2050                 2055             


Cys Asp  Glu Asp Pro Asn Ile  Cys Leu Phe Gly Ser  Cys Thr Asn 
    2060                 2065                 2070             


Thr Pro  Gly Gly Phe Gln Cys  Leu Cys Pro Pro Gly  Phe Val Leu 
    2075                 2080                 2085             


Ser Asp  Asn Gly Arg Arg Cys  Phe Asp Thr Arg Gln  Ser Phe Cys 
    2090                 2095                 2100             


Phe Thr  Asn Phe Glu Asn Gly  Lys Cys Ser Val Pro  Lys Ala Phe 
    2105                 2110                 2115             


Asn Thr  Thr Lys Ala Lys Cys  Cys Cys Ser Lys Met  Pro Gly Glu 
    2120                 2125                 2130             


Gly Trp  Gly Asp Pro Cys Glu  Leu Cys Pro Lys Asp  Asp Glu Val 
    2135                 2140                 2145             


Ala Phe  Gln Asp Leu Cys Pro  Tyr Gly His Gly Thr  Val Pro Ser 
    2150                 2155                 2160             


Leu His  Asp Thr Arg Glu Asp  Val Asn Glu Cys Leu  Glu Ser Pro 
    2165                 2170                 2175             


Gly Ile  Cys Ser Asn Gly Gln  Cys Ile Asn Thr Asp  Gly Ser Phe 
    2180                 2185                 2190             


Arg Cys  Glu Cys Pro Met Gly  Tyr Asn Leu Asp Tyr  Thr Gly Val 
    2195                 2200                 2205             


Arg Cys  Val Asp Thr Asp Glu  Cys Ser Ile Gly Asn  Pro Cys Gly 
    2210                 2215                 2220             


Asn Gly  Thr Cys Thr Asn Val  Ile Gly Ser Phe Glu  Cys Asn Cys 
    2225                 2230                 2235             


Asn Glu  Gly Phe Glu Pro Gly  Pro Met Met Asn Cys  Glu Asp Ile 
    2240                 2245                 2250             


Asn Glu  Cys Ala Gln Asn Pro  Leu Leu Cys Ala Phe  Arg Cys Met 
    2255                 2260                 2265             


Asn Thr  Phe Gly Ser Tyr Glu  Cys Thr Cys Pro Ile  Gly Tyr Ala 
    2270                 2275                 2280             


Leu Arg  Glu Asp Gln Lys Met  Cys Lys Asp Leu Asp  Glu Cys Ala 
    2285                 2290                 2295             


Glu Gly  Leu His Asp Cys Glu  Ser Arg Gly Met Met  Cys Lys Asn 
    2300                 2305                 2310             


Leu Ile  Gly Thr Phe Met Cys  Ile Cys Pro Pro Gly  Met Ala Arg 
    2315                 2320                 2325             


Arg Pro  Asp Gly Glu Gly Cys  Val Asp Glu Asn Glu  Cys Arg Thr 
    2330                 2335                 2340             


Lys Pro  Gly Ile Cys Glu Asn  Gly Arg Cys Val Asn  Ile Ile Gly 
    2345                 2350                 2355             


Ser Tyr  Arg Cys Glu Cys Asn  Glu Gly Phe Gln Ser  Ser Ser Ser 
    2360                 2365                 2370             


Gly Thr  Glu Cys Leu Asp Asn  Arg Gln Gly Leu Cys  Phe Ala Glu 
    2375                 2380                 2385             


Val Leu  Gln Thr Ile Cys Gln  Met Ala Ser Ser Ser  Arg Asn Leu 
    2390                 2395                 2400             


Val Thr  Lys Ser Glu Cys Cys  Cys Asp Gly Gly Arg  Gly Trp Gly 
    2405                 2410                 2415             


His Gln  Cys Glu Leu Cys Pro  Leu Pro Gly Thr Ala  Gln Tyr Lys 
    2420                 2425                 2430             


Lys Ile  Cys Pro His Gly Pro  Gly Tyr Thr Thr Asp  Gly Arg Asp 
    2435                 2440                 2445             


Ile Asp  Glu Cys Lys Val Met  Pro Asn Leu Cys Thr  Asn Gly Gln 
    2450                 2455                 2460             


Cys Ile  Asn Thr Met Gly Ser  Phe Arg Cys Phe Cys  Lys Val Gly 
    2465                 2470                 2475             


Tyr Thr  Thr Asp Ile Ser Gly  Thr Ser Cys Ile Asp  Leu Asp Glu 
    2480                 2485                 2490             


Cys Ser  Gln Ser Pro Lys Pro  Cys Asn Tyr Ile Cys  Lys Asn Thr 
    2495                 2500                 2505             


Glu Gly  Ser Tyr Gln Cys Ser  Cys Pro Arg Gly Tyr  Val Leu Gln 
    2510                 2515                 2520             


Glu Asp  Gly Lys Thr Cys Lys  Asp Leu Asp Glu Cys  Gln Thr Lys 
    2525                 2530                 2535             


Gln His  Asn Cys Gln Phe Leu  Cys Val Asn Thr Leu  Gly Gly Phe 
    2540                 2545                 2550             


Thr Cys  Lys Cys Pro Pro Gly  Phe Thr Gln His His  Thr Ala Cys 
    2555                 2560                 2565             


Ile Asp  Asn Asn Glu Cys Gly  Ser Gln Pro Ser Leu  Cys Gly Ala 
    2570                 2575                 2580             


Lys Gly  Ile Cys Gln Asn Thr  Pro Gly Ser Phe Ser  Cys Glu Cys 
    2585                 2590                 2595             


Gln Arg  Gly Phe Ser Leu Asp  Ala Thr Gly Leu Asn  Cys Glu Asp 
    2600                 2605                 2610             


Val Asp  Glu Cys Asp Gly Asn  His Arg Cys Gln His  Gly Cys Gln 
    2615                 2620                 2625             


Asn Ile  Leu Gly Gly Tyr Arg  Cys Gly Cys Pro Gln  Gly Tyr Ile 
    2630                 2635                 2640             


Gln His  Tyr Gln Trp Asn Gln  Cys Val Asp Glu Asn  Glu Cys Ser 
    2645                 2650                 2655             


Asn Pro  Asn Ala Cys Gly Ser  Ala Ser Cys Tyr Asn  Thr Leu Gly 
    2660                 2665                 2670             


Ser Tyr  Lys Cys Ala Cys Pro  Ser Gly Phe Ser Phe  Asp Gln Phe 
    2675                 2680                 2685             


Ser Ser  Ala Cys His Asp Val  Asn Glu Cys Ser Ser  Ser Lys Asn 
    2690                 2695                 2700             


Pro Cys  Asn Tyr Gly Cys Ser  Asn Thr Glu Gly Gly  Tyr Leu Cys 
    2705                 2710                 2715             


Gly Cys  Pro Pro Gly Tyr Tyr  Arg Val Gly Gln Gly  His Cys Val 
    2720                 2725                 2730             


Ser Gly  Met Gly Phe Asn Lys  Gly Gln Tyr Leu Ser  Leu Asp Thr 
    2735                 2740                 2745             


Glu Val  Asp Glu Glu Asn Ala  Leu Ser Pro Glu Ala  Cys Tyr Glu 
    2750                 2755                 2760             


Cys Lys  Ile Asn Gly Tyr Ser  Lys Lys Asp Ser Arg  Gln Lys Arg 
    2765                 2770                 2775             


Ser Ile  His Glu Pro Asp Pro  Thr Ala Val Glu Gln  Ile Ser Leu 
    2780                 2785                 2790             


Glu Ser  Val Asp Met Asp Ser  Pro Val Asn Met Lys  Phe Asn Leu 
    2795                 2800                 2805             


Ser His  Leu Gly Ser Lys Glu  His Ile Leu Glu Leu  Arg Pro Ala 
    2810                 2815                 2820             


Ile Gln  Pro Leu Asn Asn His  Ile Arg Tyr Val Ile  Ser Gln Gly 
    2825                 2830                 2835             


Asn Asp  Asp Ser Val Phe Arg  Ile His Gln Arg Asn  Gly Leu Ser 
    2840                 2845                 2850             


Tyr Leu  His Thr Ala Lys Lys  Lys Leu Met Pro Gly  Thr Tyr Thr 
    2855                 2860                 2865             


Leu Glu  Ile Thr Ser Ile Pro  Leu Tyr Lys Lys Lys  Glu Leu Lys 
    2870                 2875                 2880             


Lys Leu  Glu Glu Ser Asn Glu  Asp Asp Tyr Leu Leu  Gly Glu Leu 
    2885                 2890                 2895             


Gly Glu  Ala Leu Arg Met Arg  Leu Gln Ile Gln Leu  Tyr 
    2900                 2905                 2910     


<210>  5161
<211>  356
<212>  PRT
<213>  Homo Sapiens

<400>  5161

Met Met Met Lys Asn Cys Met Asp Ile Asp Glu Cys Glu Arg Asn Pro 
1               5                   10                  15      


Leu Leu Cys Arg Gly Gly Thr Cys Val Asn Thr Glu Gly Ser Phe Gln 
            20                  25                  30          


Cys Asp Cys Pro Leu Gly His Glu Leu Ser Pro Ser Arg Glu Asp Cys 
        35                  40                  45              


Val Asp Ile Asn Glu Cys Ser Leu Ser Asp Asn Leu Cys Arg Asn Gly 
    50                  55                  60                  


Lys Cys Val Asn Met Ile Gly Thr Tyr Gln Cys Ser Cys Asn Pro Gly 
65                  70                  75                  80  


Tyr Gln Ala Thr Pro Asp Arg Gln Gly Cys Thr Asp Ile Asp Glu Cys 
                85                  90                  95      


Met Ile Met Asn Gly Gly Cys Asp Thr Gln Cys Thr Asn Ser Glu Gly 
            100                 105                 110         


Ser Tyr Glu Cys Ser Cys Ser Glu Gly Tyr Ala Leu Met Pro Asp Gly 
        115                 120                 125             


Arg Ser Cys Ala Asp Ile Asp Glu Cys Glu Asn Asn Pro Asp Ile Cys 
    130                 135                 140                 


Asp Gly Gly Gln Cys Thr Asn Ile Pro Gly Glu Tyr Arg Cys Leu Cys 
145                 150                 155                 160 


Tyr Asp Gly Phe Met Ala Ser Met Asp Met Lys Thr Cys Ile Asp Val 
                165                 170                 175     


Asn Glu Cys Asp Leu Asn Ser Asn Ile Cys Met Phe Gly Glu Cys Glu 
            180                 185                 190         


Asn Thr Lys Gly Ser Phe Ile Cys His Cys Gln Leu Gly Tyr Ser Val 
        195                 200                 205             


Lys Lys Gly Thr Thr Gly Cys Thr Asp Val Asp Glu Cys Glu Ile Gly 
    210                 215                 220                 


Ala His Asn Cys Asp Met His Ala Ser Cys Leu Asn Ile Pro Gly Ser 
225                 230                 235                 240 


Phe Lys Cys Ser Cys Arg Glu Gly Trp Ile Gly Asn Gly Ile Lys Cys 
                245                 250                 255     


Ile Asp Leu Asp Glu Cys Ser Asn Gly Thr His Gln Cys Ser Ile Asn 
            260                 265                 270         


Ala Gln Cys Val Asn Thr Pro Gly Ser Tyr Arg Cys Ala Cys Ser Glu 
        275                 280                 285             


Gly Phe Thr Gly Asp Gly Phe Thr Cys Ser Asp Val Asp Glu Cys Ala 
    290                 295                 300                 


Glu Asn Ile Asn Leu Cys Glu Asn Gly Gln Cys Leu Asn Val Pro Gly 
305                 310                 315                 320 


Ala Tyr Arg Cys Glu Cys Glu Met Gly Phe Thr Pro Ala Ser Asp Ser 
                325                 330                 335     


Arg Ser Cys Gln Gly Gly Ser Pro Gly Phe Gln Leu Ile Phe Lys Leu 
            340                 345                 350         


Asp Gln Pro Gln 
        355     


<210>  5162
<211>  2809
<212>  PRT
<213>  Homo Sapiens

<400>  5162

Met Thr Leu Glu Gly Leu Tyr Leu Ala Arg Gly Pro Leu Ala Arg Leu 
1               5                   10                  15      


Leu Leu Ala Trp Ser Ala Leu Leu Cys Met Ala Gly Gly Gln Gly Arg 
            20                  25                  30          


Trp Asp Gly Ala Leu Glu Ala Ala Gly Pro Gly Arg Val Arg Arg Arg 
        35                  40                  45              


Gly Ser Pro Gly Ile Leu Gln Gly Pro Asn Val Cys Gly Ser Arg Phe 
    50                  55                  60                  


His Ala Tyr Cys Cys Pro Gly Trp Arg Thr Phe Pro Gly Arg Ser Gln 
65                  70                  75                  80  


Cys Val Val Pro Ile Cys Arg Arg Ala Cys Gly Glu Gly Phe Cys Ser 
                85                  90                  95      


Gln Pro Asn Leu Cys Thr Cys Ala Asp Gly Thr Leu Ala Pro Ser Cys 
            100                 105                 110         


Gly Val Ser Arg Gly Ser Gly Cys Ser Val Ser Cys Met Asn Gly Gly 
        115                 120                 125             


Thr Cys Arg Gly Ala Ser Cys Leu Cys Gln Lys Gly Tyr Thr Gly Thr 
    130                 135                 140                 


Val Cys Gly Gln Pro Ile Cys Asp Arg Gly Cys His Asn Gly Gly Arg 
145                 150                 155                 160 


Cys Ile Gly Pro Asn Arg Cys Ala Cys Val Tyr Gly Phe Met Gly Pro 
                165                 170                 175     


Gln Cys Glu Arg Asp Tyr Arg Thr Gly Pro Cys Phe Gly Gln Val Gly 
            180                 185                 190         


Pro Glu Gly Cys Gln His Gln Leu Thr Gly Leu Val Cys Thr Lys Ala 
        195                 200                 205             


Leu Cys Cys Ala Thr Val Gly Arg Ala Trp Gly Leu Pro Cys Glu Leu 
    210                 215                 220                 


Cys Pro Ala Gln Pro His Pro Cys Arg Arg Gly Phe Ile Pro Asn Ile 
225                 230                 235                 240 


His Thr Gly Ala Cys Gln Asp Val Asp Glu Cys Gln Ala Val Pro Gly 
                245                 250                 255     


Leu Cys Gln Gly Gly Ser Cys Val Asn Met Val Gly Ser Phe His Cys 
            260                 265                 270         


Arg Cys Pro Val Gly His Arg Leu Ser Asp Ser Ser Ala Ala Cys Glu 
        275                 280                 285             


Asp Tyr Arg Ala Gly Ala Cys Phe Ser Val Leu Phe Gly Gly Arg Cys 
    290                 295                 300                 


Ala Gly Asp Leu Ala Gly His Tyr Thr Arg Arg Gln Cys Cys Cys Asp 
305                 310                 315                 320 


Arg Gly Arg Cys Trp Ala Ala Gly Pro Val Pro Glu Leu Cys Pro Pro 
                325                 330                 335     


Arg Gly Ser Asn Glu Phe Gln Gln Leu Cys Ala Gln Arg Leu Pro Leu 
            340                 345                 350         


Leu Pro Gly His Pro Gly Leu Phe Pro Gly Leu Leu Gly Phe Gly Ser 
        355                 360                 365             


Asn Gly Met Gly Pro Pro Leu Gly Pro Ala Arg Leu Asn Pro His Gly 
    370                 375                 380                 


Ser Asp Ala Arg Gly Ile Pro Ser Leu Gly Pro Gly Asn Ser Asn Ile 
385                 390                 395                 400 


Gly Thr Ala Thr Leu Asn Gln Thr Ile Asp Ile Cys Arg His Phe Thr 
                405                 410                 415     


Asn Leu Cys Leu Asn Gly Arg Cys Leu Pro Thr Pro Ser Ser Tyr Arg 
            420                 425                 430         


Cys Glu Cys Asn Val Gly Tyr Thr Gln Asp Val Arg Gly Glu Cys Ile 
        435                 440                 445             


Asp Val Asp Glu Cys Thr Ser Ser Pro Cys His His Gly Asp Cys Val 
    450                 455                 460                 


Asn Ile Pro Gly Thr Tyr His Cys Arg Cys Tyr Pro Gly Phe Gln Ala 
465                 470                 475                 480 


Thr Pro Thr Arg Gln Ala Cys Val Asp Val Asp Glu Cys Ile Val Ser 
                485                 490                 495     


Gly Gly Leu Cys His Leu Gly Arg Cys Val Asn Thr Glu Gly Ser Phe 
            500                 505                 510         


Gln Cys Val Cys Asn Ala Gly Phe Glu Leu Ser Pro Asp Gly Lys Asn 
        515                 520                 525             


Cys Val Asp His Asn Glu Cys Ala Thr Ser Thr Met Cys Val Asn Gly 
    530                 535                 540                 


Val Cys Leu Asn Glu Asp Gly Ser Phe Ser Cys Leu Cys Lys Pro Gly 
545                 550                 555                 560 


Phe Leu Leu Ala Pro Gly Gly His Tyr Cys Met Asp Ile Asp Glu Cys 
                565                 570                 575     


Gln Thr Pro Gly Ile Cys Val Asn Gly His Cys Thr Asn Thr Glu Gly 
            580                 585                 590         


Ser Phe Arg Cys Gln Cys Leu Gly Gly Leu Ala Val Gly Thr Asp Gly 
        595                 600                 605             


Arg Val Cys Val Asp Thr His Val Arg Ser Thr Cys Tyr Gly Ala Ile 
    610                 615                 620                 


Glu Lys Gly Ser Cys Ala Arg Pro Phe Pro Gly Thr Val Thr Lys Ser 
625                 630                 635                 640 


Glu Cys Cys Cys Ala Asn Pro Asp His Gly Phe Gly Glu Pro Cys Gln 
                645                 650                 655     


Leu Cys Pro Ala Lys Asp Ser Ala Glu Phe Gln Ala Leu Cys Ser Ser 
            660                 665                 670         


Gly Leu Gly Ile Thr Thr Asp Gly Arg Asp Ile Asn Glu Cys Ala Leu 
        675                 680                 685             


Asp Pro Glu Val Cys Ala Asn Gly Val Cys Glu Asn Leu Arg Gly Ser 
    690                 695                 700                 


Tyr Arg Cys Val Cys Asn Leu Gly Tyr Glu Ala Gly Ala Ser Gly Lys 
705                 710                 715                 720 


Asp Cys Thr Asp Val Asp Glu Cys Ala Leu Asn Ser Leu Leu Cys Asp 
                725                 730                 735     


Asn Gly Trp Cys Gln Asn Ser Pro Gly Ser Tyr Ser Cys Ser Cys Pro 
            740                 745                 750         


Pro Gly Phe His Phe Trp Gln Asp Thr Glu Ile Cys Lys Asp Val Asp 
        755                 760                 765             


Glu Cys Leu Ser Ser Pro Cys Val Ser Gly Val Cys Arg Asn Leu Ala 
    770                 775                 780                 


Gly Ser Tyr Thr Cys Lys Cys Gly Pro Gly Ser Arg Leu Asp Pro Ser 
785                 790                 795                 800 


Gly Thr Phe Cys Leu Asp Ser Thr Lys Gly Thr Cys Trp Leu Lys Ile 
                805                 810                 815     


Gln Glu Ser Arg Cys Glu Val Asn Leu Gln Gly Ala Ser Leu Arg Ser 
            820                 825                 830         


Glu Cys Cys Ala Thr Leu Gly Ala Ala Trp Gly Ser Pro Cys Glu Arg 
        835                 840                 845             


Cys Glu Ile Asp Pro Ala Cys Ala Arg Gly Phe Ala Arg Met Thr Gly 
    850                 855                 860                 


Val Thr Cys Asp Asp Val Asn Glu Cys Glu Ser Phe Pro Gly Val Cys 
865                 870                 875                 880 


Pro Asn Gly Arg Cys Val Asn Thr Ala Gly Ser Phe Arg Cys Glu Cys 
                885                 890                 895     


Pro Glu Gly Leu Met Leu Asp Ala Ser Gly Arg Leu Cys Val Asp Val 
            900                 905                 910         


Arg Leu Glu Pro Cys Phe Leu Arg Trp Asp Glu Asp Glu Cys Gly Val 
        915                 920                 925             


Thr Leu Pro Gly Lys Tyr Arg Met Asp Val Cys Cys Cys Ser Ile Gly 
    930                 935                 940                 


Ala Val Trp Gly Val Glu Cys Glu Ala Cys Pro Asp Pro Glu Ser Leu 
945                 950                 955                 960 


Glu Phe Ala Ser Leu Cys Pro Arg Gly Leu Gly Phe Ala Ser Arg Asp 
                965                 970                 975     


Phe Leu Ser Gly Arg Pro Phe Tyr Lys Asp Val Asn Glu Cys Lys Val 
            980                 985                 990         


Phe Pro Gly Leu Cys Thr His Gly  Thr Cys Arg Asn Thr  Val Gly Ser 
        995                 1000                 1005             


Phe His  Cys Ala Cys Ala Gly  Gly Phe Ala Leu Asp  Ala Gln Glu 
    1010                 1015                 1020             


Arg Asn  Cys Thr Asp Ile Asp  Glu Cys Arg Ile Ser  Pro Asp Leu 
    1025                 1030                 1035             


Cys Gly  Gln Gly Thr Cys Val  Asn Thr Pro Gly Ser  Phe Glu Cys 
    1040                 1045                 1050             


Glu Cys  Phe Pro Gly Tyr Glu  Ser Gly Phe Met Leu  Met Lys Asn 
    1055                 1060                 1065             


Cys Met  Asp Val Asp Glu Cys  Ala Arg Asp Pro Leu  Leu Cys Arg 
    1070                 1075                 1080             


Gly Gly  Thr Cys Thr Asn Thr  Asp Gly Ser Tyr Lys  Cys Gln Cys 
    1085                 1090                 1095             


Pro Pro  Gly His Glu Leu Thr  Ala Lys Gly Thr Ala  Cys Glu Asp 
    1100                 1105                 1110             


Ile Asp  Glu Cys Ser Leu Ser  Asp Gly Leu Cys Pro  His Gly Gln 
    1115                 1120                 1125             


Cys Val  Asn Val Ile Gly Ala  Phe Gln Cys Ser Cys  His Ala Gly 
    1130                 1135                 1140             


Phe Gln  Ser Thr Pro Asp Arg  Gln Gly Cys Val Asp  Ile Asn Glu 
    1145                 1150                 1155             


Cys Arg  Val Gln Asn Gly Gly  Cys Asp Val His Cys  Ile Asn Thr 
    1160                 1165                 1170             


Glu Gly  Ser Tyr Arg Cys Ser  Cys Gly Gln Gly Tyr  Ser Leu Met 
    1175                 1180                 1185             


Pro Asp  Gly Arg Ala Cys Ala  Asp Val Asp Glu Cys  Glu Glu Asn 
    1190                 1195                 1200             


Pro Arg  Val Cys Asp Gln Gly  His Cys Thr Asn Met  Pro Gly Gly 
    1205                 1210                 1215             


His Arg  Cys Leu Cys Tyr Asp  Gly Phe Met Ala Thr  Pro Asp Met 
    1220                 1225                 1230             


Arg Thr  Cys Val Asp Val Asp  Glu Cys Asp Leu Asn  Pro His Ile 
    1235                 1240                 1245             


Cys Leu  His Gly Asp Cys Glu  Asn Thr Lys Gly Ser  Phe Val Cys 
    1250                 1255                 1260             


His Cys  Gln Leu Gly Tyr Met  Val Arg Lys Gly Ala  Thr Gly Cys 
    1265                 1270                 1275             


Ser Asp  Val Asp Glu Cys Glu  Val Gly Gly His Asn  Cys Asp Ser 
    1280                 1285                 1290             


His Ala  Ser Cys Leu Asn Ile  Pro Gly Ser Phe Ser  Cys Arg Cys 
    1295                 1300                 1305             


Leu Pro  Gly Trp Val Gly Asp  Gly Phe Glu Cys His  Asp Leu Asp 
    1310                 1315                 1320             


Glu Cys  Val Ser Gln Glu His  Arg Cys Ser Pro Arg  Gly Asp Cys 
    1325                 1330                 1335             


Leu Asn  Val Pro Gly Ser Tyr  Arg Cys Thr Cys Arg  Gln Gly Phe 
    1340                 1345                 1350             


Ala Gly  Asp Gly Phe Phe Cys  Glu Asp Arg Asp Glu  Cys Ala Glu 
    1355                 1360                 1365             


Asn Val  Asp Leu Cys Asp Asn  Gly Gln Cys Leu Asn  Ala Pro Gly 
    1370                 1375                 1380             


Gly Tyr  Arg Cys Glu Cys Glu  Met Gly Phe Asp Pro  Thr Glu Asp 
    1385                 1390                 1395             


His Arg  Ala Cys Gln Asp Val  Asp Glu Cys Ala Gln  Gly Asn Leu 
    1400                 1405                 1410             


Cys Ala  Phe Gly Ser Cys Glu  Asn Leu Pro Gly Met  Phe Arg Cys 
    1415                 1420                 1425             


Ile Cys  Asn Gly Gly Tyr Glu  Leu Asp Arg Gly Gly  Gly Asn Cys 
    1430                 1435                 1440             


Thr Asp  Ile Asn Glu Cys Ala  Asp Pro Val Asn Cys  Ile Asn Gly 
    1445                 1450                 1455             


Val Cys  Ile Asn Thr Pro Gly  Ser Tyr Leu Cys Ser  Cys Pro Gln 
    1460                 1465                 1470             


Asp Phe  Glu Leu Asn Pro Ser  Gly Val Gly Cys Val  Asp Thr Arg 
    1475                 1480                 1485             


Ala Gly  Asn Cys Phe Leu Glu  Thr His Asp Arg Gly  Asp Ser Gly 
    1490                 1495                 1500             


Ile Ser  Cys Ser Ala Glu Ile  Gly Val Gly Val Thr  Arg Ala Ser 
    1505                 1510                 1515             


Cys Cys  Cys Ser Leu Gly Arg  Ala Trp Gly Asn Pro  Cys Glu Leu 
    1520                 1525                 1530             


Cys Pro  Met Ala Asn Thr Thr  Glu Tyr Arg Thr Leu  Cys Pro Gly 
    1535                 1540                 1545             


Gly Glu  Gly Phe Gln Pro Asn  Arg Ile Thr Val Ile  Leu Glu Asp 
    1550                 1555                 1560             


Ile Asp  Glu Cys Gln Glu Leu  Pro Gly Leu Cys Gln  Gly Gly Asp 
    1565                 1570                 1575             


Cys Val  Asn Thr Phe Gly Ser  Phe Gln Cys Glu Cys  Pro Pro Gly 
    1580                 1585                 1590             


Tyr His  Leu Ser Glu His Thr  Arg Ile Cys Glu Asp  Ile Asp Glu 
    1595                 1600                 1605             


Cys Ser  Thr His Ser Gly Ile  Cys Gly Pro Gly Thr  Cys Tyr Asn 
    1610                 1615                 1620             


Thr Leu  Gly Asn Tyr Thr Cys  Val Cys Pro Ala Glu  Tyr Leu Gln 
    1625                 1630                 1635             


Val Asn  Gly Gly Asn Asn Cys  Met Asp Met Arg Lys  Ser Val Cys 
    1640                 1645                 1650             


Phe Arg  His Tyr Asn Gly Thr  Cys Gln Asn Glu Leu  Ala Phe Asn 
    1655                 1660                 1665             


Val Thr  Arg Lys Met Cys Cys  Cys Ser Tyr Asn Ile  Gly Gln Ala 
    1670                 1675                 1680             


Trp Asn  Arg Pro Cys Glu Ala  Cys Pro Thr Pro Ile  Ser Pro Asp 
    1685                 1690                 1695             


Tyr Gln  Ile Leu Cys Gly Asn  Gln Ala Pro Gly Phe  Leu Thr Asp 
    1700                 1705                 1710             


Ile His  Thr Gly Lys Pro Leu  Asp Ile Asp Glu Cys  Gly Glu Ile 
    1715                 1720                 1725             


Pro Ala  Ile Cys Ala Asn Gly  Ile Cys Ile Asn Gln  Ile Gly Ser 
    1730                 1735                 1740             


Phe Arg  Cys Glu Cys Pro Ala  Gly Phe Asn Tyr Asn  Ser Ile Leu 
    1745                 1750                 1755             


Leu Ala  Cys Glu Asp Val Asp  Glu Cys Gly Ser Arg  Glu Ser Pro 
    1760                 1765                 1770             


Cys Gln  Gln Asn Ala Asp Cys  Ile Asn Ile Pro Gly  Ser Tyr Arg 
    1775                 1780                 1785             


Cys Lys  Cys Thr Arg Gly Tyr  Lys Leu Ser Pro Gly  Gly Ala Cys 
    1790                 1795                 1800             


Val Gly  Arg Asn Glu Cys Arg  Glu Ile Pro Asn Val  Cys Ser His 
    1805                 1810                 1815             


Gly Asp  Cys Met Asp Thr Glu  Gly Ser Tyr Met Cys  Leu Cys His 
    1820                 1825                 1830             


Arg Gly  Phe Gln Ala Ser Ala  Asp Gln Thr Leu Cys  Met Asp Ile 
    1835                 1840                 1845             


Asp Glu  Cys Asp Arg Gln Pro  Cys Gly Asn Gly Thr  Cys Lys Asn 
    1850                 1855                 1860             


Ile Ile  Gly Ser Tyr Asn Cys  Leu Cys Phe Pro Gly  Phe Val Val 
    1865                 1870                 1875             


Thr His  Asn Gly Asp Cys Val  Asp Phe Asp Glu Cys  Thr Thr Leu 
    1880                 1885                 1890             


Val Gly  Gln Val Cys Arg Phe  Gly His Cys Leu Asn  Thr Ala Gly 
    1895                 1900                 1905             


Ser Phe  His Cys Leu Cys Gln  Asp Gly Phe Glu Leu  Thr Ala Asp 
    1910                 1915                 1920             


Gly Lys  Asn Cys Val Asp Thr  Asn Glu Cys Leu Ser  Leu Ala Gly 
    1925                 1930                 1935             


Thr Cys  Leu Pro Gly Thr Cys  Gln Asn Leu Glu Gly  Ser Phe Arg 
    1940                 1945                 1950             


Cys Ile  Cys Pro Pro Gly Phe  Gln Val Gln Ser Asp  His Cys Ile 
    1955                 1960                 1965             


Asp Ile  Asp Glu Cys Ser Glu  Glu Pro Asn Leu Cys  Leu Phe Gly 
    1970                 1975                 1980             


Thr Cys  Thr Asn Ser Pro Gly  Ser Phe Gln Cys Leu  Cys Pro Pro 
    1985                 1990                 1995             


Gly Phe  Val Leu Ser Asp Asn  Gly His Arg Cys Phe  Asp Thr Arg 
    2000                 2005                 2010             


Gln Ser  Phe Cys Phe Thr Arg  Phe Glu Ala Gly Lys  Cys Ser Val 
    2015                 2020                 2025             


Pro Lys  Ala Phe Asn Thr Thr  Lys Thr Arg Cys Cys  Cys Ser Lys 
    2030                 2035                 2040             


Arg Pro  Gly Glu Gly Trp Gly  Asp Pro Cys Glu Leu  Cys Pro Gln 
    2045                 2050                 2055             


Glu Gly  Ser Ala Ala Phe Gln  Glu Leu Cys Pro Phe  Gly His Gly 
    2060                 2065                 2070             


Ala Val  Pro Gly Pro Asp Asp  Ser Arg Glu Asp Val  Asn Glu Cys 
    2075                 2080                 2085             


Ala Glu  Asn Pro Gly Val Cys  Thr Asn Gly Val Cys  Val Asn Thr 
    2090                 2095                 2100             


Asp Gly  Ser Phe Arg Cys Glu  Cys Pro Phe Gly Tyr  Ser Leu Asp 
    2105                 2110                 2115             


Phe Thr  Gly Ile Asn Cys Val  Asp Thr Asp Glu Cys  Ser Val Gly 
    2120                 2125                 2130             


His Pro  Cys Gly Gln Gly Thr  Cys Thr Asn Val Ile  Gly Gly Phe 
    2135                 2140                 2145             


Glu Cys  Ala Cys Ala Asp Gly  Phe Glu Pro Gly Leu  Met Met Thr 
    2150                 2155                 2160             


Cys Glu  Asp Ile Asp Glu Cys  Ser Leu Asn Pro Leu  Leu Cys Ala 
    2165                 2170                 2175             


Phe Arg  Cys His Asn Thr Glu  Gly Ser Tyr Leu Cys  Thr Cys Pro 
    2180                 2185                 2190             


Ala Gly  Tyr Thr Leu Arg Glu  Asp Gly Ala Met Cys  Arg Asp Val 
    2195                 2200                 2205             


Asp Glu  Cys Ala Asp Gly Gln  Gln Asp Cys His Ala  Arg Gly Met 
    2210                 2215                 2220             


Glu Cys  Lys Asn Leu Ile Gly  Thr Phe Ala Cys Val  Cys Pro Pro 
    2225                 2230                 2235             


Gly Met  Arg Pro Leu Pro Gly  Ser Gly Glu Gly Cys  Thr Asp Asp 
    2240                 2245                 2250             


Asn Glu  Cys His Ala Gln Pro  Asp Leu Cys Val Asn  Gly Arg Cys 
    2255                 2260                 2265             


Val Asn  Thr Ala Gly Ser Phe  Arg Cys Asp Cys Asp  Glu Gly Phe 
    2270                 2275                 2280             


Gln Pro  Ser Pro Thr Leu Thr  Glu Cys His Asp Ile  Arg Gln Gly 
    2285                 2290                 2295             


Pro Cys  Phe Ala Glu Val Leu  Gln Thr Met Cys Arg  Ser Leu Ser 
    2300                 2305                 2310             


Ser Ser  Ser Glu Ala Val Thr  Arg Ala Glu Cys Cys  Cys Gly Gly 
    2315                 2320                 2325             


Gly Arg  Gly Trp Gly Pro Arg  Cys Glu Leu Cys Pro  Leu Pro Gly 
    2330                 2335                 2340             


Thr Ser  Ala Tyr Arg Lys Leu  Cys Pro His Gly Ser  Gly Tyr Thr 
    2345                 2350                 2355             


Ala Glu  Gly Arg Asp Val Asp  Glu Cys Arg Met Leu  Ala His Leu 
    2360                 2365                 2370             


Cys Ala  His Gly Glu Cys Ile  Asn Ser Leu Gly Ser  Phe Arg Cys 
    2375                 2380                 2385             


His Cys  Gln Ala Gly Tyr Thr  Pro Asp Ala Thr Ala  Thr Thr Cys 
    2390                 2395                 2400             


Leu Asp  Met Asp Glu Cys Ser  Gln Val Pro Lys Pro  Cys Thr Phe 
    2405                 2410                 2415             


Leu Cys  Lys Asn Thr Lys Gly  Ser Phe Leu Cys Ser  Cys Pro Arg 
    2420                 2425                 2430             


Gly Tyr  Leu Leu Glu Glu Asp  Gly Arg Thr Cys Lys  Asp Leu Asp 
    2435                 2440                 2445             


Glu Cys  Thr Ser Arg Gln His  Asn Cys Gln Phe Leu  Cys Val Asn 
    2450                 2455                 2460             


Thr Val  Gly Ala Phe Thr Cys  Arg Cys Pro Pro Gly  Phe Thr Gln 
    2465                 2470                 2475             


His His  Gln Ala Cys Phe Asp  Asn Asp Glu Cys Ser  Ala Gln Pro 
    2480                 2485                 2490             


Gly Pro  Cys Gly Ala His Gly  His Cys His Asn Thr  Pro Gly Ser 
    2495                 2500                 2505             


Phe Arg  Cys Glu Cys His Gln  Gly Phe Thr Leu Val  Ser Ser Gly 
    2510                 2515                 2520             


His Gly  Cys Glu Asp Val Asn  Glu Cys Asp Gly Pro  His Arg Cys 
    2525                 2530                 2535             


Gln His  Gly Cys Gln Asn Gln  Leu Gly Gly Tyr Arg  Cys Ser Cys 
    2540                 2545                 2550             


Pro Gln  Gly Phe Thr Gln His  Ser Gln Trp Ala Gln  Cys Val Asp 
    2555                 2560                 2565             


Glu Asn  Glu Cys Ala Leu Ser  Pro Pro Thr Cys Gly  Ser Ala Ser 
    2570                 2575                 2580             


Cys Arg  Asn Thr Leu Gly Gly  Phe Arg Cys Val Cys  Pro Ser Gly 
    2585                 2590                 2595             


Phe Asp  Phe Asp Gln Ala Leu  Gly Gly Cys Gln Glu  Val Asp Glu 
    2600                 2605                 2610             


Cys Ala  Gly Arg Arg Gly Pro  Cys Ser Tyr Ser Cys  Ala Asn Thr 
    2615                 2620                 2625             


Pro Gly  Gly Phe Leu Cys Gly  Cys Pro Gln Gly Tyr  Phe Arg Ala 
    2630                 2635                 2640             


Gly Gln  Gly His Cys Val Ser  Gly Leu Gly Phe Ser  Pro Gly Pro 
    2645                 2650                 2655             


Gln Asp  Thr Pro Asp Lys Glu  Glu Leu Leu Ser Ser  Glu Ala Cys 
    2660                 2665                 2670             


Tyr Glu  Cys Lys Ile Asn Gly  Leu Ser Pro Arg Asp  Arg Pro Arg 
    2675                 2680                 2685             


Arg Ser  Ala His Arg Asp His  Gln Val Asn Leu Ala  Thr Leu Asp 
    2690                 2695                 2700             


Ser Glu  Ala Leu Leu Thr Leu  Gly Leu Asn Leu Ser  His Leu Gly 
    2705                 2710                 2715             


Arg Ala  Glu Arg Ile Leu Glu  Leu Arg Pro Ala Leu  Glu Gly Leu 
    2720                 2725                 2730             


Glu Gly  Arg Ile Arg Tyr Val  Ile Val Arg Gly Asn  Glu Gln Gly 
    2735                 2740                 2745             


Phe Phe  Arg Met His His Leu  Arg Gly Val Ser Ser  Leu Gln Leu 
    2750                 2755                 2760             


Gly Arg  Arg Arg Pro Gly Pro  Gly Thr Tyr Arg Leu  Glu Val Val 
    2765                 2770                 2775             


Ser His  Met Ala Gly Pro Trp  Gly Val Gln Pro Glu  Gly Gln Pro 
    2780                 2785                 2790             


Gly Pro  Trp Gly Gln Ala Leu  Arg Leu Lys Val Gln  Leu Gln Leu 
    2795                 2800                 2805             


Leu 
    


<210>  5163
<211>  2809
<212>  PRT
<213>  Homo Sapiens

<400>  5163

Met Thr Leu Glu Gly Leu Tyr Leu Ala Arg Gly Pro Leu Ala Arg Leu 
1               5                   10                  15      


Leu Leu Ala Trp Ser Ala Leu Leu Cys Met Ala Gly Gly Gln Gly Arg 
            20                  25                  30          


Trp Asp Gly Ala Leu Glu Ala Ala Gly Pro Gly Arg Val Arg Arg Arg 
        35                  40                  45              


Gly Ser Pro Gly Ile Leu Gln Gly Pro Asn Val Cys Gly Ser Arg Phe 
    50                  55                  60                  


His Ala Tyr Cys Cys Pro Gly Trp Arg Thr Phe Pro Gly Arg Ser Gln 
65                  70                  75                  80  


Cys Val Val Pro Ile Cys Arg Arg Ala Cys Gly Glu Gly Phe Cys Ser 
                85                  90                  95      


Gln Pro Asn Leu Cys Thr Cys Ala Asp Gly Thr Leu Ala Pro Ser Cys 
            100                 105                 110         


Gly Val Ser Arg Gly Ser Gly Cys Ser Val Ser Cys Met Asn Gly Gly 
        115                 120                 125             


Thr Cys Arg Gly Ala Ser Cys Leu Cys Gln Lys Gly Tyr Thr Gly Thr 
    130                 135                 140                 


Val Cys Gly Gln Pro Ile Cys Asp Arg Gly Cys His Asn Gly Gly Arg 
145                 150                 155                 160 


Cys Ile Gly Pro Asn Arg Cys Ala Cys Val Tyr Gly Phe Met Gly Pro 
                165                 170                 175     


Gln Cys Glu Arg Asp Tyr Arg Thr Gly Pro Cys Phe Gly Gln Val Gly 
            180                 185                 190         


Pro Glu Gly Cys Gln His Gln Leu Thr Gly Leu Val Cys Thr Lys Ala 
        195                 200                 205             


Leu Cys Cys Ala Thr Val Gly Arg Ala Trp Gly Leu Pro Cys Glu Leu 
    210                 215                 220                 


Cys Pro Ala Gln Pro His Pro Cys Arg Arg Gly Phe Ile Pro Asn Ile 
225                 230                 235                 240 


His Thr Gly Ala Cys Gln Asp Val Asp Glu Cys Gln Ala Val Pro Gly 
                245                 250                 255     


Leu Cys Gln Gly Gly Ser Cys Val Asn Met Val Gly Ser Phe His Cys 
            260                 265                 270         


Arg Cys Pro Val Gly His Arg Leu Ser Asp Ser Ser Ala Ala Cys Glu 
        275                 280                 285             


Asp Tyr Arg Ala Gly Ala Cys Phe Ser Val Leu Phe Gly Gly Arg Cys 
    290                 295                 300                 


Ala Gly Asp Leu Ala Gly His Tyr Thr Arg Arg Gln Cys Cys Cys Asp 
305                 310                 315                 320 


Arg Gly Arg Cys Trp Ala Ala Gly Pro Val Pro Glu Leu Cys Pro Pro 
                325                 330                 335     


Arg Gly Ser Asn Glu Phe Gln Gln Leu Cys Ala Gln Arg Leu Pro Leu 
            340                 345                 350         


Leu Pro Gly His Pro Gly Leu Phe Pro Gly Leu Leu Gly Phe Gly Ser 
        355                 360                 365             


Asn Gly Met Gly Pro Pro Leu Gly Pro Ala Arg Leu Asn Pro His Gly 
    370                 375                 380                 


Ser Asp Ala Arg Gly Ile Pro Ser Leu Gly Pro Gly Asn Ser Asn Ile 
385                 390                 395                 400 


Gly Thr Ala Thr Leu Asn Gln Thr Ile Asp Ile Cys Arg His Phe Thr 
                405                 410                 415     


Asn Leu Cys Leu Asn Gly Arg Cys Leu Pro Thr Pro Ser Ser Tyr Arg 
            420                 425                 430         


Cys Glu Cys Asn Val Gly Tyr Thr Gln Asp Val Arg Gly Glu Cys Ile 
        435                 440                 445             


Asp Val Asp Glu Cys Thr Ser Ser Pro Cys His His Gly Asp Cys Val 
    450                 455                 460                 


Asn Ile Pro Gly Thr Tyr His Cys Arg Cys Tyr Pro Gly Phe Gln Ala 
465                 470                 475                 480 


Thr Pro Thr Arg Gln Ala Cys Val Asp Val Asp Glu Cys Ile Val Ser 
                485                 490                 495     


Gly Gly Leu Cys His Leu Gly Arg Cys Val Asn Thr Glu Gly Ser Phe 
            500                 505                 510         


Gln Cys Val Cys Asn Ala Gly Phe Glu Leu Ser Pro Asp Gly Lys Asn 
        515                 520                 525             


Cys Val Asp His Asn Glu Cys Ala Thr Ser Thr Met Cys Val Asn Gly 
    530                 535                 540                 


Val Cys Leu Asn Glu Asp Gly Ser Phe Ser Cys Leu Cys Lys Pro Gly 
545                 550                 555                 560 


Phe Leu Leu Ala Pro Gly Gly His Tyr Cys Met Asp Ile Asp Glu Cys 
                565                 570                 575     


Gln Thr Pro Gly Ile Cys Val Asn Gly His Cys Thr Asn Thr Glu Gly 
            580                 585                 590         


Ser Phe Arg Cys Gln Cys Leu Gly Gly Leu Ala Val Gly Thr Asp Gly 
        595                 600                 605             


Arg Val Cys Val Asp Thr His Val Arg Ser Thr Cys Tyr Gly Ala Ile 
    610                 615                 620                 


Glu Lys Gly Ser Cys Ala Arg Pro Phe Pro Gly Thr Val Thr Lys Ser 
625                 630                 635                 640 


Glu Cys Cys Cys Ala Asn Pro Asp His Gly Phe Gly Glu Pro Cys Gln 
                645                 650                 655     


Leu Cys Pro Ala Lys Asp Ser Ala Glu Phe Gln Ala Leu Cys Ser Ser 
            660                 665                 670         


Gly Leu Gly Ile Thr Thr Asp Gly Arg Asp Ile Asn Glu Cys Ala Leu 
        675                 680                 685             


Asp Pro Glu Val Cys Ala Asn Gly Val Cys Glu Asn Leu Arg Gly Ser 
    690                 695                 700                 


Tyr Arg Cys Val Cys Asn Leu Gly Tyr Glu Ala Gly Ala Ser Gly Lys 
705                 710                 715                 720 


Asp Cys Thr Asp Val Asp Glu Cys Ala Leu Asn Ser Leu Leu Cys Asp 
                725                 730                 735     


Asn Gly Trp Cys Gln Asn Ser Pro Gly Ser Tyr Ser Cys Ser Cys Pro 
            740                 745                 750         


Pro Gly Phe His Phe Trp Gln Asp Thr Glu Ile Cys Lys Asp Val Asp 
        755                 760                 765             


Glu Cys Leu Ser Ser Pro Cys Val Ser Gly Val Cys Arg Asn Leu Ala 
    770                 775                 780                 


Gly Ser Tyr Thr Cys Lys Cys Gly Pro Gly Ser Arg Leu Asp Pro Ser 
785                 790                 795                 800 


Gly Thr Phe Cys Leu Asp Ser Thr Lys Gly Thr Cys Trp Leu Lys Ile 
                805                 810                 815     


Gln Glu Ser Arg Cys Glu Val Asn Leu Gln Gly Ala Ser Leu Arg Ser 
            820                 825                 830         


Glu Cys Cys Ala Thr Leu Gly Ala Ala Trp Gly Ser Pro Cys Glu Arg 
        835                 840                 845             


Cys Glu Ile Asp Pro Ala Cys Ala Arg Gly Phe Ala Arg Met Thr Gly 
    850                 855                 860                 


Val Thr Cys Asp Asp Val Asn Glu Cys Glu Ser Phe Pro Gly Val Cys 
865                 870                 875                 880 


Pro Asn Gly Arg Cys Val Asn Thr Ala Gly Ser Phe Arg Cys Glu Cys 
                885                 890                 895     


Pro Glu Gly Leu Met Leu Asp Ala Ser Gly Arg Leu Cys Val Asp Val 
            900                 905                 910         


Arg Leu Glu Pro Cys Phe Leu Arg Trp Asp Glu Asp Glu Cys Gly Val 
        915                 920                 925             


Thr Leu Pro Gly Lys Tyr Arg Met Asp Val Cys Cys Cys Ser Ile Gly 
    930                 935                 940                 


Ala Val Trp Gly Val Glu Cys Glu Ala Cys Pro Asp Pro Glu Ser Leu 
945                 950                 955                 960 


Glu Phe Ala Ser Leu Cys Pro Arg Gly Leu Gly Phe Ala Ser Arg Asp 
                965                 970                 975     


Phe Leu Ser Gly Arg Pro Phe Tyr Lys Asp Val Asn Glu Cys Lys Val 
            980                 985                 990         


Phe Pro Gly Leu Cys Thr His Gly  Thr Cys Arg Asn Thr  Val Gly Ser 
        995                 1000                 1005             


Phe His  Cys Ala Cys Ala Gly  Gly Phe Ala Leu Asp  Ala Gln Glu 
    1010                 1015                 1020             


Arg Asn  Cys Thr Asp Ile Asp  Glu Cys Arg Ile Ser  Pro Asp Leu 
    1025                 1030                 1035             


Cys Gly  Gln Gly Thr Cys Val  Asn Thr Pro Gly Ser  Phe Glu Cys 
    1040                 1045                 1050             


Glu Cys  Phe Pro Gly Tyr Glu  Ser Gly Phe Met Leu  Met Lys Asn 
    1055                 1060                 1065             


Cys Met  Asp Val Asp Glu Cys  Ala Arg Asp Pro Leu  Leu Cys Arg 
    1070                 1075                 1080             


Gly Gly  Thr Cys Thr Asn Thr  Asp Gly Ser Tyr Lys  Cys Gln Cys 
    1085                 1090                 1095             


Pro Pro  Gly His Glu Leu Thr  Ala Lys Gly Thr Ala  Cys Glu Asp 
    1100                 1105                 1110             


Ile Asp  Glu Cys Ser Leu Ser  Asp Gly Leu Cys Pro  His Gly Gln 
    1115                 1120                 1125             


Cys Val  Asn Val Ile Gly Ala  Phe Gln Cys Ser Cys  His Ala Gly 
    1130                 1135                 1140             


Phe Gln  Ser Thr Pro Asp Arg  Gln Gly Cys Val Asp  Ile Asn Glu 
    1145                 1150                 1155             


Cys Arg  Val Gln Asn Gly Gly  Cys Asp Val His Cys  Ile Asn Thr 
    1160                 1165                 1170             


Glu Gly  Ser Tyr Arg Cys Ser  Cys Gly Gln Gly Tyr  Ser Leu Met 
    1175                 1180                 1185             


Pro Asp  Gly Arg Ala Cys Ala  Asp Val Asp Glu Cys  Glu Glu Asn 
    1190                 1195                 1200             


Pro Arg  Val Cys Asp Gln Gly  His Cys Thr Asn Met  Pro Gly Gly 
    1205                 1210                 1215             


His Arg  Cys Leu Cys Tyr Asp  Gly Phe Met Ala Thr  Pro Asp Met 
    1220                 1225                 1230             


Arg Thr  Cys Val Asp Val Asp  Glu Cys Asp Leu Asn  Pro His Ile 
    1235                 1240                 1245             


Cys Leu  His Gly Asp Cys Glu  Asn Thr Lys Gly Ser  Phe Val Cys 
    1250                 1255                 1260             


His Cys  Gln Leu Gly Tyr Met  Val Arg Lys Gly Ala  Thr Gly Cys 
    1265                 1270                 1275             


Ser Asp  Val Asp Glu Cys Glu  Val Gly Gly His Asn  Cys Asp Ser 
    1280                 1285                 1290             


His Ala  Ser Cys Leu Asn Ile  Pro Gly Ser Phe Ser  Cys Arg Cys 
    1295                 1300                 1305             


Leu Pro  Gly Trp Val Gly Asp  Gly Phe Glu Cys His  Asp Leu Asp 
    1310                 1315                 1320             


Glu Cys  Val Ser Gln Glu His  Arg Cys Ser Pro Arg  Gly Asp Cys 
    1325                 1330                 1335             


Leu Asn  Val Pro Gly Ser Tyr  Arg Cys Thr Cys Arg  Gln Gly Phe 
    1340                 1345                 1350             


Ala Gly  Asp Gly Phe Phe Cys  Glu Asp Arg Asp Glu  Cys Ala Glu 
    1355                 1360                 1365             


Asn Val  Asp Leu Cys Asp Asn  Gly Gln Cys Leu Asn  Ala Pro Gly 
    1370                 1375                 1380             


Gly Tyr  Arg Cys Glu Cys Glu  Met Gly Phe Asp Pro  Thr Glu Asp 
    1385                 1390                 1395             


His Arg  Ala Cys Gln Asp Val  Asp Glu Cys Ala Gln  Gly Asn Leu 
    1400                 1405                 1410             


Cys Ala  Phe Gly Ser Cys Glu  Asn Leu Pro Gly Met  Phe Arg Cys 
    1415                 1420                 1425             


Ile Cys  Asn Gly Gly Tyr Glu  Leu Asp Arg Gly Gly  Gly Asn Cys 
    1430                 1435                 1440             


Thr Asp  Ile Asn Glu Cys Ala  Asp Pro Val Asn Cys  Ile Asn Gly 
    1445                 1450                 1455             


Val Cys  Ile Asn Thr Pro Gly  Ser Tyr Leu Cys Ser  Cys Pro Gln 
    1460                 1465                 1470             


Asp Phe  Glu Leu Asn Pro Ser  Gly Val Gly Cys Val  Asp Thr Arg 
    1475                 1480                 1485             


Ala Gly  Asn Cys Phe Leu Glu  Thr His Asp Arg Gly  Asp Ser Gly 
    1490                 1495                 1500             


Ile Ser  Cys Ser Ala Glu Ile  Gly Val Gly Val Thr  Arg Ala Ser 
    1505                 1510                 1515             


Cys Cys  Cys Ser Leu Gly Arg  Ala Trp Gly Asn Pro  Cys Glu Leu 
    1520                 1525                 1530             


Cys Pro  Met Ala Asn Thr Thr  Glu Tyr Arg Thr Leu  Cys Pro Gly 
    1535                 1540                 1545             


Gly Glu  Gly Phe Gln Pro Asn  Arg Ile Thr Val Ile  Leu Glu Asp 
    1550                 1555                 1560             


Ile Asp  Glu Cys Gln Glu Leu  Pro Gly Leu Cys Gln  Gly Gly Asp 
    1565                 1570                 1575             


Cys Val  Asn Thr Phe Gly Ser  Phe Gln Cys Glu Cys  Pro Pro Gly 
    1580                 1585                 1590             


Tyr His  Leu Ser Glu His Thr  Arg Ile Cys Glu Asp  Ile Asp Glu 
    1595                 1600                 1605             


Cys Ser  Thr His Ser Gly Ile  Cys Gly Pro Gly Thr  Cys Tyr Asn 
    1610                 1615                 1620             


Thr Leu  Gly Asn Tyr Thr Cys  Val Cys Pro Ala Glu  Tyr Leu Gln 
    1625                 1630                 1635             


Val Asn  Gly Gly Asn Asn Cys  Met Asp Met Arg Lys  Ser Val Cys 
    1640                 1645                 1650             


Phe Arg  His Tyr Asn Gly Thr  Cys Gln Asn Glu Leu  Ala Phe Asn 
    1655                 1660                 1665             


Val Thr  Arg Lys Met Cys Cys  Cys Ser Tyr Asn Ile  Gly Gln Ala 
    1670                 1675                 1680             


Trp Asn  Arg Pro Cys Glu Ala  Cys Pro Thr Pro Ile  Ser Pro Asp 
    1685                 1690                 1695             


Tyr Gln  Ile Leu Cys Gly Asn  Gln Ala Pro Gly Phe  Leu Thr Asp 
    1700                 1705                 1710             


Ile His  Thr Gly Lys Pro Leu  Asp Ile Asp Glu Cys  Gly Glu Ile 
    1715                 1720                 1725             


Pro Ala  Ile Cys Ala Asn Gly  Ile Cys Ile Asn Gln  Ile Gly Ser 
    1730                 1735                 1740             


Phe Arg  Cys Glu Cys Pro Ala  Gly Phe Asn Tyr Asn  Ser Ile Leu 
    1745                 1750                 1755             


Leu Ala  Cys Glu Asp Val Asp  Glu Cys Gly Ser Arg  Glu Ser Pro 
    1760                 1765                 1770             


Cys Gln  Gln Asn Ala Asp Cys  Ile Asn Ile Pro Gly  Ser Tyr Arg 
    1775                 1780                 1785             


Cys Lys  Cys Thr Arg Gly Tyr  Lys Leu Ser Pro Gly  Gly Ala Cys 
    1790                 1795                 1800             


Val Gly  Arg Asn Glu Cys Arg  Glu Ile Pro Asn Val  Cys Ser His 
    1805                 1810                 1815             


Gly Asp  Cys Met Asp Thr Glu  Gly Ser Tyr Met Cys  Leu Cys His 
    1820                 1825                 1830             


Arg Gly  Phe Gln Ala Ser Ala  Asp Gln Thr Leu Cys  Met Asp Ile 
    1835                 1840                 1845             


Asp Glu  Cys Asp Arg Gln Pro  Cys Gly Asn Gly Thr  Cys Lys Asn 
    1850                 1855                 1860             


Ile Ile  Gly Ser Tyr Asn Cys  Leu Cys Phe Pro Gly  Phe Val Val 
    1865                 1870                 1875             


Thr His  Asn Gly Asp Cys Val  Asp Phe Asp Glu Cys  Thr Thr Leu 
    1880                 1885                 1890             


Val Gly  Gln Val Cys Arg Phe  Gly His Cys Leu Asn  Thr Ala Gly 
    1895                 1900                 1905             


Ser Phe  His Cys Leu Cys Gln  Asp Gly Phe Glu Leu  Thr Ala Asp 
    1910                 1915                 1920             


Gly Lys  Asn Cys Val Asp Thr  Asn Glu Cys Leu Ser  Leu Ala Gly 
    1925                 1930                 1935             


Thr Cys  Leu Pro Gly Thr Cys  Gln Asn Leu Glu Gly  Ser Phe Arg 
    1940                 1945                 1950             


Cys Ile  Cys Pro Pro Gly Phe  Gln Val Gln Ser Asp  His Cys Ile 
    1955                 1960                 1965             


Asp Ile  Asp Glu Cys Ser Glu  Glu Pro Asn Leu Cys  Leu Phe Gly 
    1970                 1975                 1980             


Thr Cys  Thr Asn Ser Pro Gly  Ser Phe Gln Cys Leu  Cys Pro Pro 
    1985                 1990                 1995             


Gly Phe  Val Leu Ser Asp Asn  Gly His Arg Cys Phe  Asp Thr Arg 
    2000                 2005                 2010             


Gln Ser  Phe Cys Phe Thr Arg  Phe Glu Ala Gly Lys  Cys Ser Val 
    2015                 2020                 2025             


Pro Lys  Ala Phe Asn Thr Thr  Lys Thr Arg Cys Cys  Cys Ser Lys 
    2030                 2035                 2040             


Arg Pro  Gly Glu Gly Trp Gly  Asp Pro Cys Glu Leu  Cys Pro Gln 
    2045                 2050                 2055             


Glu Gly  Ser Ala Ala Phe Gln  Glu Leu Cys Pro Phe  Gly His Gly 
    2060                 2065                 2070             


Ala Val  Pro Gly Pro Asp Asp  Ser Arg Glu Asp Val  Asn Glu Cys 
    2075                 2080                 2085             


Ala Glu  Asn Pro Gly Val Cys  Thr Asn Gly Val Cys  Val Asn Thr 
    2090                 2095                 2100             


Asp Gly  Ser Phe Arg Cys Glu  Cys Pro Phe Gly Tyr  Ser Leu Asp 
    2105                 2110                 2115             


Phe Thr  Gly Ile Asn Cys Val  Asp Thr Asp Glu Cys  Ser Val Gly 
    2120                 2125                 2130             


His Pro  Cys Gly Gln Gly Thr  Cys Thr Asn Val Ile  Gly Gly Phe 
    2135                 2140                 2145             


Glu Cys  Ala Cys Ala Asp Gly  Phe Glu Pro Gly Leu  Met Met Thr 
    2150                 2155                 2160             


Cys Glu  Asp Ile Asp Glu Cys  Ser Leu Asn Pro Leu  Leu Cys Ala 
    2165                 2170                 2175             


Phe Arg  Cys His Asn Thr Glu  Gly Ser Tyr Leu Cys  Thr Cys Pro 
    2180                 2185                 2190             


Ala Gly  Tyr Thr Leu Arg Glu  Asp Gly Ala Met Cys  Arg Asp Val 
    2195                 2200                 2205             


Asp Glu  Cys Ala Asp Gly Gln  Gln Asp Cys His Ala  Arg Gly Met 
    2210                 2215                 2220             


Glu Cys  Lys Asn Leu Ile Gly  Thr Phe Ala Cys Val  Cys Pro Pro 
    2225                 2230                 2235             


Gly Met  Arg Pro Leu Pro Gly  Ser Gly Glu Gly Cys  Thr Asp Asp 
    2240                 2245                 2250             


Asn Glu  Cys His Ala Gln Pro  Asp Leu Cys Val Asn  Gly Arg Cys 
    2255                 2260                 2265             


Val Asn  Thr Ala Gly Ser Phe  Arg Cys Asp Cys Asp  Glu Gly Phe 
    2270                 2275                 2280             


Gln Pro  Ser Pro Thr Leu Thr  Glu Cys His Asp Ile  Arg Gln Gly 
    2285                 2290                 2295             


Pro Cys  Phe Ala Glu Val Leu  Gln Thr Met Cys Arg  Ser Leu Ser 
    2300                 2305                 2310             


Ser Ser  Ser Glu Ala Val Thr  Arg Ala Glu Cys Cys  Cys Gly Gly 
    2315                 2320                 2325             


Gly Arg  Gly Trp Gly Pro Arg  Cys Glu Leu Cys Pro  Leu Pro Gly 
    2330                 2335                 2340             


Thr Ser  Ala Tyr Arg Lys Leu  Cys Pro His Gly Ser  Gly Tyr Thr 
    2345                 2350                 2355             


Ala Glu  Gly Arg Asp Val Asp  Glu Cys Arg Met Leu  Ala His Leu 
    2360                 2365                 2370             


Cys Ala  His Gly Glu Cys Ile  Asn Ser Leu Gly Ser  Phe Arg Cys 
    2375                 2380                 2385             


His Cys  Gln Ala Gly Tyr Thr  Pro Asp Ala Thr Ala  Thr Thr Cys 
    2390                 2395                 2400             


Leu Asp  Met Asp Glu Cys Ser  Gln Val Pro Lys Pro  Cys Thr Phe 
    2405                 2410                 2415             


Leu Cys  Lys Asn Thr Lys Gly  Ser Phe Leu Cys Ser  Cys Pro Arg 
    2420                 2425                 2430             


Gly Tyr  Leu Leu Glu Glu Asp  Gly Arg Thr Cys Lys  Asp Leu Asp 
    2435                 2440                 2445             


Glu Cys  Thr Ser Arg Gln His  Asn Cys Gln Phe Leu  Cys Val Asn 
    2450                 2455                 2460             


Thr Val  Gly Ala Phe Thr Cys  Arg Cys Pro Pro Gly  Phe Thr Gln 
    2465                 2470                 2475             


His His  Gln Ala Cys Phe Asp  Asn Asp Glu Cys Ser  Ala Gln Pro 
    2480                 2485                 2490             


Gly Pro  Cys Gly Ala His Gly  His Cys His Asn Thr  Pro Gly Ser 
    2495                 2500                 2505             


Phe Arg  Cys Glu Cys His Gln  Gly Phe Thr Leu Val  Ser Ser Gly 
    2510                 2515                 2520             


His Gly  Cys Glu Asp Val Asn  Glu Cys Asp Gly Pro  His Arg Cys 
    2525                 2530                 2535             


Gln His  Gly Cys Gln Asn Gln  Leu Gly Gly Tyr Arg  Cys Ser Cys 
    2540                 2545                 2550             


Pro Gln  Gly Phe Thr Gln His  Ser Gln Trp Ala Gln  Cys Val Asp 
    2555                 2560                 2565             


Glu Asn  Glu Cys Ala Leu Ser  Pro Pro Thr Cys Gly  Ser Ala Ser 
    2570                 2575                 2580             


Cys Arg  Asn Thr Leu Gly Gly  Phe Arg Cys Val Cys  Pro Ser Gly 
    2585                 2590                 2595             


Phe Asp  Phe Asp Gln Ala Leu  Gly Gly Cys Gln Glu  Val Asp Glu 
    2600                 2605                 2610             


Cys Ala  Gly Arg Arg Gly Pro  Cys Ser Tyr Ser Cys  Ala Asn Thr 
    2615                 2620                 2625             


Pro Gly  Gly Phe Leu Cys Gly  Cys Pro Gln Gly Tyr  Phe Arg Ala 
    2630                 2635                 2640             


Gly Gln  Gly His Cys Val Ser  Gly Leu Gly Phe Ser  Pro Gly Pro 
    2645                 2650                 2655             


Gln Asp  Thr Pro Asp Lys Glu  Glu Leu Leu Ser Ser  Glu Ala Cys 
    2660                 2665                 2670             


Tyr Glu  Cys Lys Ile Asn Gly  Leu Ser Pro Arg Asp  Arg Pro Arg 
    2675                 2680                 2685             


Arg Ser  Ala His Arg Asp His  Gln Val Asn Leu Ala  Thr Leu Asp 
    2690                 2695                 2700             


Ser Glu  Ala Leu Leu Thr Leu  Gly Leu Asn Leu Ser  His Leu Gly 
    2705                 2710                 2715             


Arg Ala  Glu Arg Ile Leu Glu  Leu Arg Pro Ala Leu  Glu Gly Leu 
    2720                 2725                 2730             


Glu Gly  Arg Ile Arg Tyr Val  Ile Val Arg Gly Asn  Glu Gln Gly 
    2735                 2740                 2745             


Phe Phe  Arg Met His His Leu  Arg Gly Val Ser Ser  Leu Gln Leu 
    2750                 2755                 2760             


Gly Arg  Arg Arg Pro Gly Pro  Gly Thr Tyr Arg Leu  Glu Val Val 
    2765                 2770                 2775             


Ser His  Met Ala Gly Pro Trp  Gly Val Gln Pro Glu  Gly Gln Pro 
    2780                 2785                 2790             


Gly Pro  Trp Gly Gln Ala Leu  Arg Leu Lys Val Gln  Leu Gln Leu 
    2795                 2800                 2805             


Leu 
    


<210>  5164
<211>  2809
<212>  PRT
<213>  Homo Sapiens

<400>  5164

Met Thr Leu Glu Gly Leu Tyr Leu Ala Arg Gly Pro Leu Ala Arg Leu 
1               5                   10                  15      


Leu Leu Ala Trp Ser Ala Leu Leu Cys Met Ala Gly Gly Gln Gly Arg 
            20                  25                  30          


Trp Asp Gly Ala Leu Glu Ala Ala Gly Pro Gly Arg Val Arg Arg Arg 
        35                  40                  45              


Gly Ser Pro Gly Ile Leu Gln Gly Pro Asn Val Cys Gly Ser Arg Phe 
    50                  55                  60                  


His Ala Tyr Cys Cys Pro Gly Trp Arg Thr Phe Pro Gly Arg Ser Gln 
65                  70                  75                  80  


Cys Val Val Pro Ile Cys Arg Arg Ala Cys Gly Glu Gly Phe Cys Ser 
                85                  90                  95      


Gln Pro Asn Leu Cys Thr Cys Ala Asp Gly Thr Leu Ala Pro Ser Cys 
            100                 105                 110         


Gly Val Ser Arg Gly Ser Gly Cys Ser Val Ser Cys Met Asn Gly Gly 
        115                 120                 125             


Thr Cys Arg Gly Ala Ser Cys Leu Cys Gln Lys Gly Tyr Thr Gly Thr 
    130                 135                 140                 


Val Cys Gly Gln Pro Ile Cys Asp Arg Gly Cys His Asn Gly Gly Arg 
145                 150                 155                 160 


Cys Ile Gly Pro Asn Arg Cys Ala Cys Val Tyr Gly Phe Met Gly Pro 
                165                 170                 175     


Gln Cys Glu Arg Asp Tyr Arg Thr Gly Pro Cys Phe Gly Gln Val Gly 
            180                 185                 190         


Pro Glu Gly Cys Gln His Gln Leu Thr Gly Leu Val Cys Thr Lys Ala 
        195                 200                 205             


Leu Cys Cys Ala Thr Val Gly Arg Ala Trp Gly Leu Pro Cys Glu Leu 
    210                 215                 220                 


Cys Pro Ala Gln Pro His Pro Cys Arg Arg Gly Phe Ile Pro Asn Ile 
225                 230                 235                 240 


His Thr Gly Ala Cys Gln Asp Val Asp Glu Cys Gln Ala Val Pro Gly 
                245                 250                 255     


Leu Cys Gln Gly Gly Ser Cys Val Asn Met Val Gly Ser Phe His Cys 
            260                 265                 270         


Arg Cys Pro Val Gly His Arg Leu Ser Asp Ser Ser Ala Ala Cys Glu 
        275                 280                 285             


Asp Tyr Arg Ala Gly Ala Cys Phe Ser Val Leu Phe Gly Gly Arg Cys 
    290                 295                 300                 


Ala Gly Asp Leu Ala Gly His Tyr Thr Arg Arg Gln Cys Cys Cys Asp 
305                 310                 315                 320 


Arg Gly Arg Cys Trp Ala Ala Gly Pro Val Pro Glu Leu Cys Pro Pro 
                325                 330                 335     


Arg Gly Ser Asn Glu Phe Gln Gln Leu Cys Ala Gln Arg Leu Pro Leu 
            340                 345                 350         


Leu Pro Gly His Pro Gly Leu Phe Pro Gly Leu Leu Gly Phe Gly Ser 
        355                 360                 365             


Asn Gly Met Gly Pro Pro Leu Gly Pro Ala Arg Leu Asn Pro His Gly 
    370                 375                 380                 


Ser Asp Ala Arg Gly Ile Pro Ser Leu Gly Pro Gly Asn Ser Asn Ile 
385                 390                 395                 400 


Gly Thr Ala Thr Leu Asn Gln Thr Ile Asp Ile Cys Arg His Phe Thr 
                405                 410                 415     


Asn Leu Cys Leu Asn Gly Arg Cys Leu Pro Thr Pro Ser Ser Tyr Arg 
            420                 425                 430         


Cys Glu Cys Asn Val Gly Tyr Thr Gln Asp Val Arg Gly Glu Cys Ile 
        435                 440                 445             


Asp Val Asp Glu Cys Thr Ser Ser Pro Cys His His Gly Asp Cys Val 
    450                 455                 460                 


Asn Ile Pro Gly Thr Tyr His Cys Arg Cys Tyr Pro Gly Phe Gln Ala 
465                 470                 475                 480 


Thr Pro Thr Arg Gln Ala Cys Val Asp Val Asp Glu Cys Ile Val Ser 
                485                 490                 495     


Gly Gly Leu Cys His Leu Gly Arg Cys Val Asn Thr Glu Gly Ser Phe 
            500                 505                 510         


Gln Cys Val Cys Asn Ala Gly Phe Glu Leu Ser Pro Asp Gly Lys Asn 
        515                 520                 525             


Cys Val Asp His Asn Glu Cys Ala Thr Ser Thr Met Cys Val Asn Gly 
    530                 535                 540                 


Val Cys Leu Asn Glu Asp Gly Ser Phe Ser Cys Leu Cys Lys Pro Gly 
545                 550                 555                 560 


Phe Leu Leu Ala Pro Gly Gly His Tyr Cys Met Asp Ile Asp Glu Cys 
                565                 570                 575     


Gln Thr Pro Gly Ile Cys Val Asn Gly His Cys Thr Asn Thr Glu Gly 
            580                 585                 590         


Ser Phe Arg Cys Gln Cys Leu Gly Gly Leu Ala Val Gly Thr Asp Gly 
        595                 600                 605             


Arg Val Cys Val Asp Thr His Val Arg Ser Thr Cys Tyr Gly Ala Ile 
    610                 615                 620                 


Glu Lys Gly Ser Cys Ala Arg Pro Phe Pro Gly Thr Val Thr Lys Ser 
625                 630                 635                 640 


Glu Cys Cys Cys Ala Asn Pro Asp His Gly Phe Gly Glu Pro Cys Gln 
                645                 650                 655     


Leu Cys Pro Ala Lys Asp Ser Ala Glu Phe Gln Ala Leu Cys Ser Ser 
            660                 665                 670         


Gly Leu Gly Ile Thr Thr Asp Gly Arg Asp Ile Asn Glu Cys Ala Leu 
        675                 680                 685             


Asp Pro Glu Val Cys Ala Asn Gly Val Cys Glu Asn Leu Arg Gly Ser 
    690                 695                 700                 


Tyr Arg Cys Val Cys Asn Leu Gly Tyr Glu Ala Gly Ala Ser Gly Lys 
705                 710                 715                 720 


Asp Cys Thr Asp Val Asp Glu Cys Ala Leu Asn Ser Leu Leu Cys Asp 
                725                 730                 735     


Asn Gly Trp Cys Gln Asn Ser Pro Gly Ser Tyr Ser Cys Ser Cys Pro 
            740                 745                 750         


Pro Gly Phe His Phe Trp Gln Asp Thr Glu Ile Cys Lys Asp Val Asp 
        755                 760                 765             


Glu Cys Leu Ser Ser Pro Cys Val Ser Gly Val Cys Arg Asn Leu Ala 
    770                 775                 780                 


Gly Ser Tyr Thr Cys Lys Cys Gly Pro Gly Ser Arg Leu Asp Pro Ser 
785                 790                 795                 800 


Gly Thr Phe Cys Leu Asp Ser Thr Lys Gly Thr Cys Trp Leu Lys Ile 
                805                 810                 815     


Gln Glu Ser Arg Cys Glu Val Asn Leu Gln Gly Ala Ser Leu Arg Ser 
            820                 825                 830         


Glu Cys Cys Ala Thr Leu Gly Ala Ala Trp Gly Ser Pro Cys Glu Arg 
        835                 840                 845             


Cys Glu Ile Asp Pro Ala Cys Ala Arg Gly Phe Ala Arg Met Thr Gly 
    850                 855                 860                 


Val Thr Cys Asp Asp Val Asn Glu Cys Glu Ser Phe Pro Gly Val Cys 
865                 870                 875                 880 


Pro Asn Gly Arg Cys Val Asn Thr Ala Gly Ser Phe Arg Cys Glu Cys 
                885                 890                 895     


Pro Glu Gly Leu Met Leu Asp Ala Ser Gly Arg Leu Cys Val Asp Val 
            900                 905                 910         


Arg Leu Glu Pro Cys Phe Leu Arg Trp Asp Glu Asp Glu Cys Gly Val 
        915                 920                 925             


Thr Leu Pro Gly Lys Tyr Arg Met Asp Val Cys Cys Cys Ser Ile Gly 
    930                 935                 940                 


Ala Val Trp Gly Val Glu Cys Glu Ala Cys Pro Asp Pro Glu Ser Leu 
945                 950                 955                 960 


Glu Phe Ala Ser Leu Cys Pro Arg Gly Leu Gly Phe Ala Ser Arg Asp 
                965                 970                 975     


Phe Leu Ser Gly Arg Pro Phe Tyr Lys Asp Val Asn Glu Cys Lys Val 
            980                 985                 990         


Phe Pro Gly Leu Cys Thr His Gly  Thr Cys Arg Asn Thr  Val Gly Ser 
        995                 1000                 1005             


Phe His  Cys Ala Cys Ala Gly  Gly Phe Ala Leu Asp  Ala Gln Glu 
    1010                 1015                 1020             


Arg Asn  Cys Thr Asp Ile Asp  Glu Cys Arg Ile Ser  Pro Asp Leu 
    1025                 1030                 1035             


Cys Gly  Gln Gly Thr Cys Val  Asn Thr Pro Gly Ser  Phe Glu Cys 
    1040                 1045                 1050             


Glu Cys  Phe Pro Gly Tyr Glu  Ser Gly Phe Met Leu  Met Lys Asn 
    1055                 1060                 1065             


Cys Met  Asp Val Asp Glu Cys  Ala Arg Asp Pro Leu  Leu Cys Arg 
    1070                 1075                 1080             


Gly Gly  Thr Cys Thr Asn Thr  Asp Gly Ser Tyr Lys  Cys Gln Cys 
    1085                 1090                 1095             


Pro Pro  Gly His Glu Leu Thr  Ala Lys Gly Thr Ala  Cys Glu Asp 
    1100                 1105                 1110             


Ile Asp  Glu Cys Ser Leu Ser  Asp Gly Leu Cys Pro  His Gly Gln 
    1115                 1120                 1125             


Cys Val  Asn Val Ile Gly Ala  Phe Gln Cys Ser Cys  His Ala Gly 
    1130                 1135                 1140             


Phe Gln  Ser Thr Pro Asp Arg  Gln Gly Cys Val Asp  Ile Asn Glu 
    1145                 1150                 1155             


Cys Arg  Val Gln Asn Gly Gly  Cys Asp Val His Cys  Ile Asn Thr 
    1160                 1165                 1170             


Glu Gly  Ser Tyr Arg Cys Ser  Cys Gly Gln Gly Tyr  Ser Leu Met 
    1175                 1180                 1185             


Pro Asp  Gly Arg Ala Cys Ala  Asp Val Asp Glu Cys  Glu Glu Asn 
    1190                 1195                 1200             


Pro Arg  Val Cys Asp Gln Gly  His Cys Thr Asn Met  Pro Gly Gly 
    1205                 1210                 1215             


His Arg  Cys Leu Cys Tyr Asp  Gly Phe Met Ala Thr  Pro Asp Met 
    1220                 1225                 1230             


Arg Thr  Cys Val Asp Val Asp  Glu Cys Asp Leu Asn  Pro His Ile 
    1235                 1240                 1245             


Cys Leu  His Gly Asp Cys Glu  Asn Thr Lys Gly Ser  Phe Val Cys 
    1250                 1255                 1260             


His Cys  Gln Leu Gly Tyr Met  Val Arg Lys Gly Ala  Thr Gly Cys 
    1265                 1270                 1275             


Ser Asp  Val Asp Glu Cys Glu  Val Gly Gly His Asn  Cys Asp Ser 
    1280                 1285                 1290             


His Ala  Ser Cys Leu Asn Ile  Pro Gly Ser Phe Ser  Cys Arg Cys 
    1295                 1300                 1305             


Leu Pro  Gly Trp Val Gly Asp  Gly Phe Glu Cys His  Asp Leu Asp 
    1310                 1315                 1320             


Glu Cys  Val Ser Gln Glu His  Arg Cys Ser Pro Arg  Gly Asp Cys 
    1325                 1330                 1335             


Leu Asn  Val Pro Gly Ser Tyr  Arg Cys Thr Cys Arg  Gln Gly Phe 
    1340                 1345                 1350             


Ala Gly  Asp Gly Phe Phe Cys  Glu Asp Arg Asp Glu  Cys Ala Glu 
    1355                 1360                 1365             


Asn Val  Asp Leu Cys Asp Asn  Gly Gln Cys Leu Asn  Ala Pro Gly 
    1370                 1375                 1380             


Gly Tyr  Arg Cys Glu Cys Glu  Met Gly Phe Asp Pro  Thr Glu Asp 
    1385                 1390                 1395             


His Arg  Ala Cys Gln Asp Val  Asp Glu Cys Ala Gln  Gly Asn Leu 
    1400                 1405                 1410             


Cys Ala  Phe Gly Ser Cys Glu  Asn Leu Pro Gly Met  Phe Arg Cys 
    1415                 1420                 1425             


Ile Cys  Asn Gly Gly Tyr Glu  Leu Asp Arg Gly Gly  Gly Asn Cys 
    1430                 1435                 1440             


Thr Asp  Ile Asn Glu Cys Ala  Asp Pro Val Asn Cys  Ile Asn Gly 
    1445                 1450                 1455             


Val Cys  Ile Asn Thr Pro Gly  Ser Tyr Leu Cys Ser  Cys Pro Gln 
    1460                 1465                 1470             


Asp Phe  Glu Leu Asn Pro Ser  Gly Val Gly Cys Val  Asp Thr Arg 
    1475                 1480                 1485             


Ala Gly  Asn Cys Phe Leu Glu  Thr His Asp Arg Gly  Asp Ser Gly 
    1490                 1495                 1500             


Ile Ser  Cys Ser Ala Glu Ile  Gly Val Gly Val Thr  Arg Ala Ser 
    1505                 1510                 1515             


Cys Cys  Cys Ser Leu Gly Arg  Ala Trp Gly Asn Pro  Cys Glu Leu 
    1520                 1525                 1530             


Cys Pro  Met Ala Asn Thr Thr  Glu Tyr Arg Thr Leu  Cys Pro Gly 
    1535                 1540                 1545             


Gly Glu  Gly Phe Gln Pro Asn  Arg Ile Thr Val Ile  Leu Glu Asp 
    1550                 1555                 1560             


Ile Asp  Glu Cys Gln Glu Leu  Pro Gly Leu Cys Gln  Gly Gly Asp 
    1565                 1570                 1575             


Cys Val  Asn Thr Phe Gly Ser  Phe Gln Cys Glu Cys  Pro Pro Gly 
    1580                 1585                 1590             


Tyr His  Leu Ser Glu His Thr  Arg Ile Cys Glu Asp  Ile Asp Glu 
    1595                 1600                 1605             


Cys Ser  Thr His Ser Gly Ile  Cys Gly Pro Gly Thr  Cys Tyr Asn 
    1610                 1615                 1620             


Thr Leu  Gly Asn Tyr Thr Cys  Val Cys Pro Ala Glu  Tyr Leu Gln 
    1625                 1630                 1635             


Val Asn  Gly Gly Asn Asn Cys  Met Asp Met Arg Lys  Ser Val Cys 
    1640                 1645                 1650             


Phe Arg  His Tyr Asn Gly Thr  Cys Gln Asn Glu Leu  Ala Phe Asn 
    1655                 1660                 1665             


Val Thr  Arg Lys Met Cys Cys  Cys Ser Tyr Asn Ile  Gly Gln Ala 
    1670                 1675                 1680             


Trp Asn  Arg Pro Cys Glu Ala  Cys Pro Thr Pro Ile  Ser Pro Asp 
    1685                 1690                 1695             


Tyr Gln  Ile Leu Cys Gly Asn  Gln Ala Pro Gly Phe  Leu Thr Asp 
    1700                 1705                 1710             


Ile His  Thr Gly Lys Pro Leu  Asp Ile Asp Glu Cys  Gly Glu Ile 
    1715                 1720                 1725             


Pro Ala  Ile Cys Ala Asn Gly  Ile Cys Ile Asn Gln  Ile Gly Ser 
    1730                 1735                 1740             


Phe Arg  Cys Glu Cys Pro Ala  Gly Phe Asn Tyr Asn  Ser Ile Leu 
    1745                 1750                 1755             


Leu Ala  Cys Glu Asp Val Asp  Glu Cys Gly Ser Arg  Glu Ser Pro 
    1760                 1765                 1770             


Cys Gln  Gln Asn Ala Asp Cys  Ile Asn Ile Pro Gly  Ser Tyr Arg 
    1775                 1780                 1785             


Cys Lys  Cys Thr Arg Gly Tyr  Lys Leu Ser Pro Gly  Gly Ala Cys 
    1790                 1795                 1800             


Val Gly  Arg Asn Glu Cys Arg  Glu Ile Pro Asn Val  Cys Ser His 
    1805                 1810                 1815             


Gly Asp  Cys Met Asp Thr Glu  Gly Ser Tyr Met Cys  Leu Cys His 
    1820                 1825                 1830             


Arg Gly  Phe Gln Ala Ser Ala  Asp Gln Thr Leu Cys  Met Asp Ile 
    1835                 1840                 1845             


Asp Glu  Cys Asp Arg Gln Pro  Cys Gly Asn Gly Thr  Cys Lys Asn 
    1850                 1855                 1860             


Ile Ile  Gly Ser Tyr Asn Cys  Leu Cys Phe Pro Gly  Phe Val Val 
    1865                 1870                 1875             


Thr His  Asn Gly Asp Cys Val  Asp Phe Asp Glu Cys  Thr Thr Leu 
    1880                 1885                 1890             


Val Gly  Gln Val Cys Arg Phe  Gly His Cys Leu Asn  Thr Ala Gly 
    1895                 1900                 1905             


Ser Phe  His Cys Leu Cys Gln  Asp Gly Phe Glu Leu  Thr Ala Asp 
    1910                 1915                 1920             


Gly Lys  Asn Cys Val Asp Thr  Asn Glu Cys Leu Ser  Leu Ala Gly 
    1925                 1930                 1935             


Thr Cys  Leu Pro Gly Thr Cys  Gln Asn Leu Glu Gly  Ser Phe Arg 
    1940                 1945                 1950             


Cys Ile  Cys Pro Pro Gly Phe  Gln Val Gln Ser Asp  His Cys Ile 
    1955                 1960                 1965             


Asp Ile  Asp Glu Cys Ser Glu  Glu Pro Asn Leu Cys  Leu Phe Gly 
    1970                 1975                 1980             


Thr Cys  Thr Asn Ser Pro Gly  Ser Phe Gln Cys Leu  Cys Pro Pro 
    1985                 1990                 1995             


Gly Phe  Val Leu Ser Asp Asn  Gly His Arg Cys Phe  Asp Thr Arg 
    2000                 2005                 2010             


Gln Ser  Phe Cys Phe Thr Arg  Phe Glu Ala Gly Lys  Cys Ser Val 
    2015                 2020                 2025             


Pro Lys  Ala Phe Asn Thr Thr  Lys Thr Arg Cys Cys  Cys Ser Lys 
    2030                 2035                 2040             


Arg Pro  Gly Glu Gly Trp Gly  Asp Pro Cys Glu Leu  Cys Pro Gln 
    2045                 2050                 2055             


Glu Gly  Ser Ala Ala Phe Gln  Glu Leu Cys Pro Phe  Gly His Gly 
    2060                 2065                 2070             


Ala Val  Pro Gly Pro Asp Asp  Ser Arg Glu Asp Val  Asn Glu Cys 
    2075                 2080                 2085             


Ala Glu  Asn Pro Gly Val Cys  Thr Asn Gly Val Cys  Val Asn Thr 
    2090                 2095                 2100             


Asp Gly  Ser Phe Arg Cys Glu  Cys Pro Phe Gly Tyr  Ser Leu Asp 
    2105                 2110                 2115             


Phe Thr  Gly Ile Asn Cys Val  Asp Thr Asp Glu Cys  Ser Val Gly 
    2120                 2125                 2130             


His Pro  Cys Gly Gln Gly Thr  Cys Thr Asn Val Ile  Gly Gly Phe 
    2135                 2140                 2145             


Glu Cys  Ala Cys Ala Asp Gly  Phe Glu Pro Gly Leu  Met Met Thr 
    2150                 2155                 2160             


Cys Glu  Asp Ile Asp Glu Cys  Ser Leu Asn Pro Leu  Leu Cys Ala 
    2165                 2170                 2175             


Phe Arg  Cys His Asn Thr Glu  Gly Ser Tyr Leu Cys  Thr Cys Pro 
    2180                 2185                 2190             


Ala Gly  Tyr Thr Leu Arg Glu  Asp Gly Ala Met Cys  Arg Asp Val 
    2195                 2200                 2205             


Asp Glu  Cys Ala Asp Gly Gln  Gln Asp Cys His Ala  Arg Gly Met 
    2210                 2215                 2220             


Glu Cys  Lys Asn Leu Ile Gly  Thr Phe Ala Cys Val  Cys Pro Pro 
    2225                 2230                 2235             


Gly Met  Arg Pro Leu Pro Gly  Ser Gly Glu Gly Cys  Thr Asp Asp 
    2240                 2245                 2250             


Asn Glu  Cys His Ala Gln Pro  Asp Leu Cys Val Asn  Gly Arg Cys 
    2255                 2260                 2265             


Val Asn  Thr Ala Gly Ser Phe  Arg Cys Asp Cys Asp  Glu Gly Phe 
    2270                 2275                 2280             


Gln Pro  Ser Pro Thr Leu Thr  Glu Cys His Asp Ile  Arg Gln Gly 
    2285                 2290                 2295             


Pro Cys  Phe Ala Glu Val Leu  Gln Thr Met Cys Arg  Ser Leu Ser 
    2300                 2305                 2310             


Ser Ser  Ser Glu Ala Val Thr  Arg Ala Glu Cys Cys  Cys Gly Gly 
    2315                 2320                 2325             


Gly Arg  Gly Trp Gly Pro Arg  Cys Glu Leu Cys Pro  Leu Pro Gly 
    2330                 2335                 2340             


Thr Ser  Ala Tyr Arg Lys Leu  Cys Pro His Gly Ser  Gly Tyr Thr 
    2345                 2350                 2355             


Ala Glu  Gly Arg Asp Val Asp  Glu Cys Arg Met Leu  Ala His Leu 
    2360                 2365                 2370             


Cys Ala  His Gly Glu Cys Ile  Asn Ser Leu Gly Ser  Phe Arg Cys 
    2375                 2380                 2385             


His Cys  Gln Ala Gly Tyr Thr  Pro Asp Ala Thr Ala  Thr Thr Cys 
    2390                 2395                 2400             


Leu Asp  Met Asp Glu Cys Ser  Gln Val Pro Lys Pro  Cys Thr Phe 
    2405                 2410                 2415             


Leu Cys  Lys Asn Thr Lys Gly  Ser Phe Leu Cys Ser  Cys Pro Arg 
    2420                 2425                 2430             


Gly Tyr  Leu Leu Glu Glu Asp  Gly Arg Thr Cys Lys  Asp Leu Asp 
    2435                 2440                 2445             


Glu Cys  Thr Ser Arg Gln His  Asn Cys Gln Phe Leu  Cys Val Asn 
    2450                 2455                 2460             


Thr Val  Gly Ala Phe Thr Cys  Arg Cys Pro Pro Gly  Phe Thr Gln 
    2465                 2470                 2475             


His His  Gln Ala Cys Phe Asp  Asn Asp Glu Cys Ser  Ala Gln Pro 
    2480                 2485                 2490             


Gly Pro  Cys Gly Ala His Gly  His Cys His Asn Thr  Pro Gly Ser 
    2495                 2500                 2505             


Phe Arg  Cys Glu Cys His Gln  Gly Phe Thr Leu Val  Ser Ser Gly 
    2510                 2515                 2520             


His Gly  Cys Glu Asp Val Asn  Glu Cys Asp Gly Pro  His Arg Cys 
    2525                 2530                 2535             


Gln His  Gly Cys Gln Asn Gln  Leu Gly Gly Tyr Arg  Cys Ser Cys 
    2540                 2545                 2550             


Pro Gln  Gly Phe Thr Gln His  Ser Gln Trp Ala Gln  Cys Val Asp 
    2555                 2560                 2565             


Glu Asn  Glu Cys Ala Leu Ser  Pro Pro Thr Cys Gly  Ser Ala Ser 
    2570                 2575                 2580             


Cys Arg  Asn Thr Leu Gly Gly  Phe Arg Cys Val Cys  Pro Ser Gly 
    2585                 2590                 2595             


Phe Asp  Phe Asp Gln Ala Leu  Gly Gly Cys Gln Glu  Val Asp Glu 
    2600                 2605                 2610             


Cys Ala  Gly Arg Arg Gly Pro  Cys Ser Tyr Ser Cys  Ala Asn Thr 
    2615                 2620                 2625             


Pro Gly  Gly Phe Leu Cys Gly  Cys Pro Gln Gly Tyr  Phe Arg Ala 
    2630                 2635                 2640             


Gly Gln  Gly His Cys Val Ser  Gly Leu Gly Phe Ser  Pro Gly Pro 
    2645                 2650                 2655             


Gln Asp  Thr Pro Asp Lys Glu  Glu Leu Leu Ser Ser  Glu Ala Cys 
    2660                 2665                 2670             


Tyr Glu  Cys Lys Ile Asn Gly  Leu Ser Pro Arg Asp  Arg Pro Arg 
    2675                 2680                 2685             


Arg Ser  Ala His Arg Asp His  Gln Val Asn Leu Ala  Thr Leu Asp 
    2690                 2695                 2700             


Ser Glu  Ala Leu Leu Thr Leu  Gly Leu Asn Leu Ser  His Leu Gly 
    2705                 2710                 2715             


Arg Ala  Glu Arg Ile Leu Glu  Leu Arg Pro Ala Leu  Glu Gly Leu 
    2720                 2725                 2730             


Glu Gly  Arg Ile Arg Tyr Val  Ile Val Arg Gly Asn  Glu Gln Gly 
    2735                 2740                 2745             


Phe Phe  Arg Met His His Leu  Arg Gly Val Ser Ser  Leu Gln Leu 
    2750                 2755                 2760             


Gly Arg  Arg Arg Pro Gly Pro  Gly Thr Tyr Arg Leu  Glu Val Val 
    2765                 2770                 2775             


Ser His  Met Ala Gly Pro Trp  Gly Val Gln Pro Glu  Gly Gln Pro 
    2780                 2785                 2790             


Gly Pro  Trp Gly Gln Ala Leu  Arg Leu Lys Val Gln  Leu Gln Leu 
    2795                 2800                 2805             


Leu 
    


<210>  5165
<211>  171
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5165

Xaa Phe Thr Arg Phe Glu Ala Gly Lys Cys Ser Val Pro Lys Ala Phe 
1               5                   10                  15      


Asn Thr Thr Lys Thr Arg Cys Cys Cys Ser Lys Arg Pro Gly Glu Gly 
            20                  25                  30          


Trp Gly Asp Pro Cys Glu Leu Cys Pro Gln Glu Gly Ser Asp Val Asn 
        35                  40                  45              


Glu Cys Ala Glu Asn Pro Gly Val Cys Thr Asn Gly Val Cys Val Asn 
    50                  55                  60                  


Thr Asp Gly Ser Phe Arg Cys Glu Cys Pro Phe Gly Tyr Ser Leu Asp 
65                  70                  75                  80  


Phe Thr Gly Ile Asn Cys Val Asp Thr Asp Glu Cys Ser Val Gly His 
                85                  90                  95      


Pro Cys Gly Gln Gly Thr Cys Thr Asn Val Ile Gly Gly Phe Glu Cys 
            100                 105                 110         


Ala Cys Ala Asp Gly Phe Glu Pro Gly Leu Met Met Thr Cys Glu Asp 
        115                 120                 125             


Ile Asp Glu Cys Ser Leu Asn Pro Leu Leu Cys Ala Phe Arg Cys His 
    130                 135                 140                 


Asn Thr Glu Gly Ser Tyr Leu Cys Thr Cys Pro Ala Gly Tyr Thr Leu 
145                 150                 155                 160 


Arg Glu Asp Gly Ala Met Cys Arg Asp Val Asp 
                165                 170     


<210>  5166
<211>  188
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5166

Xaa Tyr Gln Ile Leu Cys Gly Asn Gln Ala Pro Gly Phe Leu Thr Asp 
1               5                   10                  15      


Ile His Thr Gly Lys Pro Leu Asp Val Asp Glu Cys Gly Ser Arg Glu 
            20                  25                  30          


Ser Pro Cys Gln Gln Asn Ala Asp Cys Ile Asn Ile Pro Gly Ser Tyr 
        35                  40                  45              


Arg Cys Lys Cys Thr Arg Gly Tyr Lys Leu Ser Pro Gly Gly Ala Cys 
    50                  55                  60                  


Val Gly Arg Asn Glu Cys Arg Glu Ile Pro Asn Val Cys Ser His Gly 
65                  70                  75                  80  


Asp Cys Met Asp Thr Glu Gly Ser Tyr Met Cys Leu Cys His Arg Gly 
                85                  90                  95      


Phe Gln Ala Ser Ala Asp Gln Thr Leu Cys Met Asp Ile Asp Glu Cys 
            100                 105                 110         


Asp Arg Gln Pro Cys Gly Asn Gly Thr Cys Lys Asn Ile Ile Gly Ser 
        115                 120                 125             


Tyr Asn Cys Leu Cys Phe Pro Gly Phe Val Val Thr His Asn Gly Asp 
    130                 135                 140                 


Cys Val Asp Phe Asp Glu Cys Thr Thr Leu Val Gly Gln Val Cys Arg 
145                 150                 155                 160 


Phe Gly His Cys Leu Asn Thr Ala Gly Ser Phe His Cys Leu Cys Gln 
                165                 170                 175     


Asp Gly Phe Glu Leu Thr Ala Asp Gly Lys Asn Cys 
            180                 185             


<210>  5167
<211>  627
<212>  PRT
<213>  Homo Sapiens

<400>  5167

Met Cys Val Pro Arg Ser Gly Leu Ile Leu Ser Cys Ile Cys Leu Tyr 
1               5                   10                  15      


Cys Gly Val Leu Leu Pro Val Leu Leu Pro Asn Leu Pro Phe Leu Thr 
            20                  25                  30          


Cys Leu Ser Met Ser Thr Leu Glu Ser Val Thr Tyr Leu Pro Glu Lys 
        35                  40                  45              


Gly Leu Tyr Cys Gln Arg Leu Pro Ser Ser Arg Thr His Gly Gly Thr 
    50                  55                  60                  


Glu Ser Leu Lys Gly Lys Asn Thr Glu Asn Met Gly Phe Tyr Gly Thr 
65                  70                  75                  80  


Leu Lys Met Ile Phe Tyr Lys Met Lys Arg Lys Leu Asp His Gly Ser 
                85                  90                  95      


Glu Val Arg Ser Phe Ser Leu Gly Lys Lys Pro Cys Lys Val Ser Glu 
            100                 105                 110         


Tyr Thr Ser Thr Thr Gly Leu Val Pro Cys Ser Ala Thr Pro Thr Thr 
        115                 120                 125             


Phe Gly Asp Leu Arg Ala Ala Asn Gly Gln Gly Gln Gln Arg Arg Arg 
    130                 135                 140                 


Ile Thr Ser Val Gln Pro Pro Thr Gly Leu Gln Glu Trp Leu Lys Met 
145                 150                 155                 160 


Phe Gln Ser Trp Ser Gly Pro Glu Lys Leu Leu Ala Leu Asp Glu Leu 
                165                 170                 175     


Ile Asp Ser Cys Glu Pro Thr Gln Val Lys His Met Met Gln Val Ile 
            180                 185                 190         


Glu Pro Gln Phe Gln Arg Asp Phe Ile Ser Leu Leu Pro Lys Glu Leu 
        195                 200                 205             


Ala Leu Tyr Val Leu Ser Phe Leu Glu Pro Lys Asp Leu Leu Gln Ala 
    210                 215                 220                 


Ala Gln Thr Cys Arg Tyr Trp Arg Ile Leu Ala Glu Asp Asn Leu Leu 
225                 230                 235                 240 


Trp Arg Glu Lys Cys Lys Glu Glu Gly Ile Asp Glu Pro Leu His Ile 
                245                 250                 255     


Lys Arg Arg Lys Val Ile Lys Pro Gly Phe Ile His Ser Pro Trp Lys 
            260                 265                 270         


Ser Ala Tyr Ile Arg Gln His Arg Ile Asp Thr Asn Trp Arg Arg Gly 
        275                 280                 285             


Glu Leu Lys Ser Pro Lys Val Leu Lys Gly His Asp Asp His Val Ile 
    290                 295                 300                 


Thr Cys Leu Gln Phe Cys Gly Asn Arg Ile Val Ser Gly Ser Asp Asp 
305                 310                 315                 320 


Asn Thr Leu Lys Val Trp Ser Ala Val Thr Gly Lys Cys Leu Arg Thr 
                325                 330                 335     


Leu Val Gly His Thr Gly Gly Val Trp Ser Ser Gln Met Arg Asp Asn 
            340                 345                 350         


Ile Ile Ile Ser Gly Ser Thr Asp Arg Thr Leu Lys Val Trp Asn Ala 
        355                 360                 365             


Glu Thr Gly Glu Cys Ile His Thr Leu Tyr Gly His Thr Ser Thr Val 
    370                 375                 380                 


Arg Cys Met His Leu His Glu Lys Arg Val Val Ser Gly Ser Arg Asp 
385                 390                 395                 400 


Ala Thr Leu Arg Val Trp Asp Ile Glu Thr Gly Gln Cys Leu His Val 
                405                 410                 415     


Leu Met Gly His Val Ala Ala Val Arg Cys Val Gln Tyr Asp Gly Arg 
            420                 425                 430         


Arg Val Val Ser Gly Ala Tyr Asp Phe Met Val Lys Val Trp Asp Pro 
        435                 440                 445             


Glu Thr Glu Thr Cys Leu His Thr Leu Gln Gly His Thr Asn Arg Val 
    450                 455                 460                 


Tyr Ser Leu Gln Phe Asp Gly Ile His Val Val Ser Gly Ser Leu Asp 
465                 470                 475                 480 


Thr Ser Ile Arg Val Trp Asp Val Glu Thr Gly Asn Cys Ile His Thr 
                485                 490                 495     


Leu Thr Gly His Gln Ser Leu Thr Ser Gly Met Glu Leu Lys Asp Asn 
            500                 505                 510         


Ile Leu Val Ser Gly Asn Ala Asp Ser Thr Val Lys Ile Trp Asp Ile 
        515                 520                 525             


Lys Thr Gly Gln Cys Leu Gln Thr Leu Gln Gly Pro Asn Lys His Gln 
    530                 535                 540                 


Ser Ala Val Thr Cys Leu Gln Phe Asn Lys Asn Phe Val Ile Thr Ser 
545                 550                 555                 560 


Ser Asp Asp Gly Thr Val Lys Leu Trp Asp Leu Lys Thr Gly Glu Phe 
                565                 570                 575     


Ile Arg Asn Leu Val Thr Leu Glu Ser Gly Gly Ser Gly Gly Val Val 
            580                 585                 590         


Trp Arg Ile Arg Ala Ser Asn Thr Lys Leu Val Cys Ala Val Gly Ser 
        595                 600                 605             


Arg Asn Gly Thr Glu Glu Thr Lys Leu Leu Val Leu Asp Phe Asp Val 
    610                 615                 620                 


Asp Met Lys 
625         


<210>  5168
<211>  627
<212>  PRT
<213>  Homo Sapiens

<400>  5168

Met Cys Val Pro Arg Ser Gly Leu Ile Leu Ser Cys Ile Cys Leu Tyr 
1               5                   10                  15      


Cys Gly Val Leu Leu Pro Val Leu Leu Pro Asn Leu Pro Phe Leu Thr 
            20                  25                  30          


Cys Leu Ser Met Ser Thr Leu Glu Ser Val Thr Tyr Leu Pro Glu Lys 
        35                  40                  45              


Gly Leu Tyr Cys Gln Arg Leu Pro Ser Ser Arg Thr His Gly Gly Thr 
    50                  55                  60                  


Glu Ser Leu Lys Gly Lys Asn Thr Glu Asn Met Gly Phe Tyr Gly Thr 
65                  70                  75                  80  


Leu Lys Met Ile Phe Tyr Lys Met Lys Arg Lys Leu Asp His Gly Ser 
                85                  90                  95      


Glu Val Arg Ser Phe Ser Leu Gly Lys Lys Pro Cys Lys Val Ser Glu 
            100                 105                 110         


Tyr Thr Ser Thr Thr Gly Leu Val Pro Cys Ser Ala Thr Pro Thr Thr 
        115                 120                 125             


Phe Gly Asp Leu Arg Ala Ala Asn Gly Gln Gly Gln Gln Arg Arg Arg 
    130                 135                 140                 


Ile Thr Ser Val Gln Pro Pro Thr Gly Leu Gln Glu Trp Leu Lys Met 
145                 150                 155                 160 


Phe Gln Ser Trp Ser Gly Pro Glu Lys Leu Leu Ala Leu Asp Glu Leu 
                165                 170                 175     


Ile Asp Ser Cys Glu Pro Thr Gln Val Lys His Met Met Gln Val Ile 
            180                 185                 190         


Glu Pro Gln Phe Gln Arg Asp Phe Ile Ser Leu Leu Pro Lys Glu Leu 
        195                 200                 205             


Ala Leu Tyr Val Leu Ser Phe Leu Glu Pro Lys Asp Leu Leu Gln Ala 
    210                 215                 220                 


Ala Gln Thr Cys Arg Tyr Trp Arg Ile Leu Ala Glu Asp Asn Leu Leu 
225                 230                 235                 240 


Trp Arg Glu Lys Cys Lys Glu Glu Gly Ile Asp Glu Pro Leu His Ile 
                245                 250                 255     


Lys Arg Arg Lys Val Ile Lys Pro Gly Phe Ile His Ser Pro Trp Lys 
            260                 265                 270         


Ser Ala Tyr Ile Arg Gln His Arg Ile Asp Thr Asn Trp Arg Arg Gly 
        275                 280                 285             


Glu Leu Lys Ser Pro Lys Val Leu Lys Gly His Asp Asp His Val Ile 
    290                 295                 300                 


Thr Cys Leu Gln Phe Cys Gly Asn Arg Ile Val Ser Gly Ser Asp Asp 
305                 310                 315                 320 


Asn Thr Leu Lys Val Trp Ser Ala Val Thr Gly Lys Cys Leu Arg Thr 
                325                 330                 335     


Leu Val Gly His Thr Gly Gly Val Trp Ser Ser Gln Met Arg Asp Asn 
            340                 345                 350         


Ile Ile Ile Ser Gly Ser Thr Asp Arg Thr Leu Lys Val Trp Asn Ala 
        355                 360                 365             


Glu Thr Gly Glu Cys Ile His Thr Leu Tyr Gly His Thr Ser Thr Val 
    370                 375                 380                 


Arg Cys Met His Leu His Glu Lys Arg Val Val Ser Gly Ser Arg Asp 
385                 390                 395                 400 


Ala Thr Leu Arg Val Trp Asp Ile Glu Thr Gly Gln Cys Leu His Val 
                405                 410                 415     


Leu Met Gly His Val Ala Ala Val Arg Cys Val Gln Tyr Asp Gly Arg 
            420                 425                 430         


Arg Val Val Ser Gly Ala Tyr Asp Phe Met Val Lys Val Trp Asp Pro 
        435                 440                 445             


Glu Thr Glu Thr Cys Leu His Thr Leu Gln Gly His Thr Asn Arg Val 
    450                 455                 460                 


Tyr Ser Leu Gln Phe Asp Gly Ile His Val Val Ser Gly Ser Leu Asp 
465                 470                 475                 480 


Thr Ser Ile Arg Val Trp Asp Val Glu Thr Gly Asn Cys Ile His Thr 
                485                 490                 495     


Leu Thr Gly His Gln Ser Leu Thr Ser Gly Met Glu Leu Lys Asp Asn 
            500                 505                 510         


Ile Leu Val Ser Gly Asn Ala Asp Ser Thr Val Lys Ile Trp Asp Ile 
        515                 520                 525             


Lys Thr Gly Gln Cys Leu Gln Thr Leu Gln Gly Pro Asn Lys His Gln 
    530                 535                 540                 


Ser Ala Val Thr Cys Leu Gln Phe Asn Lys Asn Phe Val Ile Thr Ser 
545                 550                 555                 560 


Ser Asp Asp Gly Thr Val Lys Leu Trp Asp Leu Lys Thr Gly Glu Phe 
                565                 570                 575     


Ile Arg Asn Leu Val Thr Leu Glu Ser Gly Gly Ser Gly Gly Val Val 
            580                 585                 590         


Trp Arg Ile Arg Ala Ser Asn Thr Lys Leu Val Cys Ala Val Gly Ser 
        595                 600                 605             


Arg Asn Gly Thr Glu Glu Thr Lys Leu Leu Val Leu Asp Phe Asp Val 
    610                 615                 620                 


Asp Met Lys 
625         


<210>  5169
<211>  70
<212>  PRT
<213>  Homo Sapiens

<400>  5169

Met Asn Gln Glu Leu Leu Ser Val Gly Ser Lys Arg Arg Arg Thr Gly 
1               5                   10                  15      


Gly Ser Leu Arg Gly Asn Pro Ser Ser Ser Gln Val Asp Glu Glu Gln 
            20                  25                  30          


Met Asn Arg Val Val Glu Glu Glu Gln Gln Gln Gln Leu Arg Gln Gln 
        35                  40                  45              


Glu Glu Glu His Thr Ala Arg Asn Gly Glu Val Val Gly Val Glu Pro 
    50                  55                  60                  


Arg Pro Gly Gly Gln Asn 
65                  70  


<210>  5170
<211>  70
<212>  PRT
<213>  Homo Sapiens

<400>  5170

Met Asn Gln Glu Leu Leu Ser Val Gly Ser Lys Arg Arg Arg Thr Gly 
1               5                   10                  15      


Gly Ser Leu Arg Gly Asn Pro Ser Ser Ser Gln Val Asp Glu Glu Gln 
            20                  25                  30          


Met Asn Arg Val Val Glu Glu Glu Gln Gln Gln Gln Leu Arg Gln Gln 
        35                  40                  45              


Glu Glu Glu His Thr Ala Arg Asn Gly Glu Val Val Gly Val Glu Pro 
    50                  55                  60                  


Arg Pro Gly Gly Gln Asn 
65                  70  


<210>  5171
<211>  70
<212>  PRT
<213>  Homo Sapiens

<400>  5171

Met Asn Gln Glu Leu Leu Ser Val Gly Ser Lys Arg Arg Arg Thr Gly 
1               5                   10                  15      


Gly Ser Leu Arg Gly Asn Pro Ser Ser Ser Gln Val Asp Glu Glu Gln 
            20                  25                  30          


Met Asn Arg Val Val Glu Glu Glu Gln Gln Gln Gln Leu Arg Gln Gln 
        35                  40                  45              


Glu Glu Glu His Thr Ala Arg Asn Gly Glu Val Val Gly Val Glu Pro 
    50                  55                  60                  


Arg Pro Gly Gly Gln Asn 
65                  70  


<210>  5172
<211>  158
<212>  PRT
<213>  Homo Sapiens

<400>  5172

Met Asn Gln Glu Leu Leu Ser Val Gly Ser Lys Arg Arg Arg Thr Gly 
1               5                   10                  15      


Gly Ser Leu Arg Gly Asn Pro Ser Ser Ser Gln Val Asp Glu Glu Gln 
            20                  25                  30          


Met Asn Arg Val Val Glu Glu Glu Gln Gln Gln Gln Leu Arg Gln Gln 
        35                  40                  45              


Glu Glu Glu His Thr Ala Arg Asn Gly Glu Val Val Gly Val Glu Pro 
    50                  55                  60                  


Arg Pro Gly Gly Gln Asn Asp Ser Gln Gln Gly Gln Leu Glu Glu Asn 
65                  70                  75                  80  


Asn Asn Arg Phe Ile Ser Val Asp Glu Asp Ser Ser Gly Asn Gln Glu 
                85                  90                  95      


Glu Gln Glu Glu Asp Glu Glu His Ala Gly Glu Gln Asp Glu Glu Asp 
            100                 105                 110         


Glu Glu Glu Glu Glu Met Asp Gln Glu Ser Asp Asp Phe Asp Gln Ser 
        115                 120                 125             


Asp Asp Ser Ser Arg Glu Asp Glu His Thr His Thr Asn Ser Val Thr 
    130                 135                 140                 


Asn Ser Ser Ser Ile Val Asp Leu Pro Val His Gln Leu Ser 
145                 150                 155             


<210>  5173
<211>  707
<212>  PRT
<213>  Homo Sapiens

<400>  5173

Met Asn Gln Glu Leu Leu Ser Val Gly Ser Lys Arg Arg Arg Thr Gly 
1               5                   10                  15      


Gly Ser Leu Arg Gly Asn Pro Ser Ser Ser Gln Val Asp Glu Glu Gln 
            20                  25                  30          


Met Asn Arg Val Val Glu Glu Glu Gln Gln Gln Gln Leu Arg Gln Gln 
        35                  40                  45              


Glu Glu Glu His Thr Ala Arg Asn Gly Glu Val Val Gly Val Glu Pro 
    50                  55                  60                  


Arg Pro Gly Gly Gln Asn Asp Ser Gln Gln Gly Gln Leu Glu Glu Asn 
65                  70                  75                  80  


Asn Asn Arg Phe Ile Ser Val Asp Glu Asp Ser Ser Gly Asn Gln Glu 
                85                  90                  95      


Glu Gln Glu Glu Asp Glu Glu His Ala Gly Glu Gln Asp Glu Glu Asp 
            100                 105                 110         


Glu Glu Glu Glu Glu Met Asp Gln Glu Ser Asp Asp Phe Asp Gln Ser 
        115                 120                 125             


Asp Asp Ser Ser Arg Glu Asp Glu His Thr His Thr Asn Ser Val Thr 
    130                 135                 140                 


Asn Ser Ser Ser Ile Val Asp Leu Pro Val His Gln Leu Ser Ser Pro 
145                 150                 155                 160 


Phe Tyr Thr Lys Thr Thr Lys Met Lys Arg Lys Leu Asp His Gly Ser 
                165                 170                 175     


Glu Val Arg Ser Phe Ser Leu Gly Lys Lys Pro Cys Lys Val Ser Glu 
            180                 185                 190         


Tyr Thr Ser Thr Thr Gly Leu Val Pro Cys Ser Ala Thr Pro Thr Thr 
        195                 200                 205             


Phe Gly Asp Leu Arg Ala Ala Asn Gly Gln Gly Gln Gln Arg Arg Arg 
    210                 215                 220                 


Ile Thr Ser Val Gln Pro Pro Thr Gly Leu Gln Glu Trp Leu Lys Met 
225                 230                 235                 240 


Phe Gln Ser Trp Ser Gly Pro Glu Lys Leu Leu Ala Leu Asp Glu Leu 
                245                 250                 255     


Ile Asp Ser Cys Glu Pro Thr Gln Val Lys His Met Met Gln Val Ile 
            260                 265                 270         


Glu Pro Gln Phe Gln Arg Asp Phe Ile Ser Leu Leu Pro Lys Glu Leu 
        275                 280                 285             


Ala Leu Tyr Val Leu Ser Phe Leu Glu Pro Lys Asp Leu Leu Gln Ala 
    290                 295                 300                 


Ala Gln Thr Cys Arg Tyr Trp Arg Ile Leu Ala Glu Asp Asn Leu Leu 
305                 310                 315                 320 


Trp Arg Glu Lys Cys Lys Glu Glu Gly Ile Asp Glu Pro Leu His Ile 
                325                 330                 335     


Lys Arg Arg Lys Val Ile Lys Pro Gly Phe Ile His Ser Pro Trp Lys 
            340                 345                 350         


Ser Ala Tyr Ile Arg Gln His Arg Ile Asp Thr Asn Trp Arg Arg Gly 
        355                 360                 365             


Glu Leu Lys Ser Pro Lys Val Leu Lys Gly His Asp Asp His Val Ile 
    370                 375                 380                 


Thr Cys Leu Gln Phe Cys Gly Asn Arg Ile Val Ser Gly Ser Asp Asp 
385                 390                 395                 400 


Asn Thr Leu Lys Val Trp Ser Ala Val Thr Gly Lys Cys Leu Arg Thr 
                405                 410                 415     


Leu Val Gly His Thr Gly Gly Val Trp Ser Ser Gln Met Arg Asp Asn 
            420                 425                 430         


Ile Ile Ile Ser Gly Ser Thr Asp Arg Thr Leu Lys Val Trp Asn Ala 
        435                 440                 445             


Glu Thr Gly Glu Cys Ile His Thr Leu Tyr Gly His Thr Ser Thr Val 
    450                 455                 460                 


Arg Cys Met His Leu His Glu Lys Arg Val Val Ser Gly Ser Arg Asp 
465                 470                 475                 480 


Ala Thr Leu Arg Val Trp Asp Ile Glu Thr Gly Gln Cys Leu His Val 
                485                 490                 495     


Leu Met Gly His Val Ala Ala Val Arg Cys Val Gln Tyr Asp Gly Arg 
            500                 505                 510         


Arg Val Val Ser Gly Ala Tyr Asp Phe Met Val Lys Val Trp Asp Pro 
        515                 520                 525             


Glu Thr Glu Thr Cys Leu His Thr Leu Gln Gly His Thr Asn Arg Val 
    530                 535                 540                 


Tyr Ser Leu Gln Phe Asp Gly Ile His Val Val Ser Gly Ser Leu Asp 
545                 550                 555                 560 


Thr Ser Ile Arg Val Trp Asp Val Glu Thr Gly Asn Cys Ile His Thr 
                565                 570                 575     


Leu Thr Gly His Gln Ser Leu Thr Ser Gly Met Glu Leu Lys Asp Asn 
            580                 585                 590         


Ile Leu Val Ser Gly Asn Ala Asp Ser Thr Val Lys Ile Trp Asp Ile 
        595                 600                 605             


Lys Thr Gly Gln Cys Leu Gln Thr Leu Gln Gly Pro Asn Lys His Gln 
    610                 615                 620                 


Ser Ala Val Thr Cys Leu Gln Phe Asn Lys Asn Phe Val Ile Thr Ser 
625                 630                 635                 640 


Ser Asp Asp Gly Thr Val Lys Leu Trp Asp Leu Lys Thr Gly Glu Phe 
                645                 650                 655     


Ile Arg Asn Leu Val Thr Leu Glu Ser Gly Gly Ser Gly Gly Val Val 
            660                 665                 670         


Trp Arg Ile Arg Ala Ser Asn Thr Lys Leu Val Cys Ala Val Gly Ser 
        675                 680                 685             


Arg Asn Gly Thr Glu Glu Thr Lys Leu Leu Val Leu Asp Phe Asp Val 
    690                 695                 700                 


Asp Met Lys 
705         


<210>  5174
<211>  707
<212>  PRT
<213>  Homo Sapiens

<400>  5174

Met Asn Gln Glu Leu Leu Ser Val Gly Ser Lys Arg Arg Arg Thr Gly 
1               5                   10                  15      


Gly Ser Leu Arg Gly Asn Pro Ser Ser Ser Gln Val Asp Glu Glu Gln 
            20                  25                  30          


Met Asn Arg Val Val Glu Glu Glu Gln Gln Gln Gln Leu Arg Gln Gln 
        35                  40                  45              


Glu Glu Glu His Thr Ala Arg Asn Gly Glu Val Val Gly Val Glu Pro 
    50                  55                  60                  


Arg Pro Gly Gly Gln Asn Asp Ser Gln Gln Gly Gln Leu Glu Glu Asn 
65                  70                  75                  80  


Asn Asn Arg Phe Ile Ser Val Asp Glu Asp Ser Ser Gly Asn Gln Glu 
                85                  90                  95      


Glu Gln Glu Glu Asp Glu Glu His Ala Gly Glu Gln Asp Glu Glu Asp 
            100                 105                 110         


Glu Glu Glu Glu Glu Met Asp Gln Glu Ser Asp Asp Phe Asp Gln Ser 
        115                 120                 125             


Asp Asp Ser Ser Arg Glu Asp Glu His Thr His Thr Asn Ser Val Thr 
    130                 135                 140                 


Asn Ser Ser Ser Ile Val Asp Leu Pro Val His Gln Leu Ser Ser Pro 
145                 150                 155                 160 


Phe Tyr Thr Lys Thr Thr Lys Met Lys Arg Lys Leu Asp His Gly Ser 
                165                 170                 175     


Glu Val Arg Ser Phe Ser Leu Gly Lys Lys Pro Cys Lys Val Ser Glu 
            180                 185                 190         


Tyr Thr Ser Thr Thr Gly Leu Val Pro Cys Ser Ala Thr Pro Thr Thr 
        195                 200                 205             


Phe Gly Asp Leu Arg Ala Ala Asn Gly Gln Gly Gln Gln Arg Arg Arg 
    210                 215                 220                 


Ile Thr Ser Val Gln Pro Pro Thr Gly Leu Gln Glu Trp Leu Lys Met 
225                 230                 235                 240 


Phe Gln Ser Trp Ser Gly Pro Glu Lys Leu Leu Ala Leu Asp Glu Leu 
                245                 250                 255     


Ile Asp Ser Cys Glu Pro Thr Gln Val Lys His Met Met Gln Val Ile 
            260                 265                 270         


Glu Pro Gln Phe Gln Arg Asp Phe Ile Ser Leu Leu Pro Lys Glu Leu 
        275                 280                 285             


Ala Leu Tyr Val Leu Ser Phe Leu Glu Pro Lys Asp Leu Leu Gln Ala 
    290                 295                 300                 


Ala Gln Thr Cys Arg Tyr Trp Arg Ile Leu Ala Glu Asp Asn Leu Leu 
305                 310                 315                 320 


Trp Arg Glu Lys Cys Lys Glu Glu Gly Ile Asp Glu Pro Leu His Ile 
                325                 330                 335     


Lys Arg Arg Lys Val Ile Lys Pro Gly Phe Ile His Ser Pro Trp Lys 
            340                 345                 350         


Ser Ala Tyr Ile Arg Gln His Arg Ile Asp Thr Asn Trp Arg Arg Gly 
        355                 360                 365             


Glu Leu Lys Ser Pro Lys Val Leu Lys Gly His Asp Asp His Val Ile 
    370                 375                 380                 


Thr Cys Leu Gln Phe Cys Gly Asn Arg Ile Val Ser Gly Ser Asp Asp 
385                 390                 395                 400 


Asn Thr Leu Lys Val Trp Ser Ala Val Thr Gly Lys Cys Leu Arg Thr 
                405                 410                 415     


Leu Val Gly His Thr Gly Gly Val Trp Ser Ser Gln Met Arg Asp Asn 
            420                 425                 430         


Ile Ile Ile Ser Gly Ser Thr Asp Arg Thr Leu Lys Val Trp Asn Ala 
        435                 440                 445             


Glu Thr Gly Glu Cys Ile His Thr Leu Tyr Gly His Thr Ser Thr Val 
    450                 455                 460                 


Arg Cys Met His Leu His Glu Lys Arg Val Val Ser Gly Ser Arg Asp 
465                 470                 475                 480 


Ala Thr Leu Arg Val Trp Asp Ile Glu Thr Gly Gln Cys Leu His Val 
                485                 490                 495     


Leu Met Gly His Val Ala Ala Val Arg Cys Val Gln Tyr Asp Gly Arg 
            500                 505                 510         


Arg Val Val Ser Gly Ala Tyr Asp Phe Met Val Lys Val Trp Asp Pro 
        515                 520                 525             


Glu Thr Glu Thr Cys Leu His Thr Leu Gln Gly His Thr Asn Arg Val 
    530                 535                 540                 


Tyr Ser Leu Gln Phe Asp Gly Ile His Val Val Ser Gly Ser Leu Asp 
545                 550                 555                 560 


Thr Ser Ile Arg Val Trp Asp Val Glu Thr Gly Asn Cys Ile His Thr 
                565                 570                 575     


Leu Thr Gly His Gln Ser Leu Thr Ser Gly Met Glu Leu Lys Asp Asn 
            580                 585                 590         


Ile Leu Val Ser Gly Asn Ala Asp Ser Thr Val Lys Ile Trp Asp Ile 
        595                 600                 605             


Lys Thr Gly Gln Cys Leu Gln Thr Leu Gln Gly Pro Asn Lys His Gln 
    610                 615                 620                 


Ser Ala Val Thr Cys Leu Gln Phe Asn Lys Asn Phe Val Ile Thr Ser 
625                 630                 635                 640 


Ser Asp Asp Gly Thr Val Lys Leu Trp Asp Leu Lys Thr Gly Glu Phe 
                645                 650                 655     


Ile Arg Asn Leu Val Thr Leu Glu Ser Gly Gly Ser Gly Gly Val Val 
            660                 665                 670         


Trp Arg Ile Arg Ala Ser Asn Thr Lys Leu Val Cys Ala Val Gly Ser 
        675                 680                 685             


Arg Asn Gly Thr Glu Glu Thr Lys Leu Leu Val Leu Asp Phe Asp Val 
    690                 695                 700                 


Asp Met Lys 
705         


<210>  5175
<211>  707
<212>  PRT
<213>  Homo Sapiens

<400>  5175

Met Asn Gln Glu Leu Leu Ser Val Gly Ser Lys Arg Arg Arg Thr Gly 
1               5                   10                  15      


Gly Ser Leu Arg Gly Asn Pro Ser Ser Ser Gln Val Asp Glu Glu Gln 
            20                  25                  30          


Met Asn Arg Val Val Glu Glu Glu Gln Gln Gln Gln Leu Arg Gln Gln 
        35                  40                  45              


Glu Glu Glu His Thr Ala Arg Asn Gly Glu Val Val Gly Val Glu Pro 
    50                  55                  60                  


Arg Pro Gly Gly Gln Asn Asp Ser Gln Gln Gly Gln Leu Glu Glu Asn 
65                  70                  75                  80  


Asn Asn Arg Phe Ile Ser Val Asp Glu Asp Ser Ser Gly Asn Gln Glu 
                85                  90                  95      


Glu Gln Glu Glu Asp Glu Glu His Ala Gly Glu Gln Asp Glu Glu Asp 
            100                 105                 110         


Glu Glu Glu Glu Glu Met Asp Gln Glu Ser Asp Asp Phe Asp Gln Ser 
        115                 120                 125             


Asp Asp Ser Ser Arg Glu Asp Glu His Thr His Thr Asn Ser Val Thr 
    130                 135                 140                 


Asn Ser Ser Ser Ile Val Asp Leu Pro Val His Gln Leu Ser Ser Pro 
145                 150                 155                 160 


Phe Tyr Thr Lys Thr Thr Lys Met Lys Arg Lys Leu Asp His Gly Ser 
                165                 170                 175     


Glu Val Arg Ser Phe Ser Leu Gly Lys Lys Pro Cys Lys Val Ser Glu 
            180                 185                 190         


Tyr Thr Ser Thr Thr Gly Leu Val Pro Cys Ser Ala Thr Pro Thr Thr 
        195                 200                 205             


Phe Gly Asp Leu Arg Ala Ala Asn Gly Gln Gly Gln Gln Arg Arg Arg 
    210                 215                 220                 


Ile Thr Ser Val Gln Pro Pro Thr Gly Leu Gln Glu Trp Leu Lys Met 
225                 230                 235                 240 


Phe Gln Ser Trp Ser Gly Pro Glu Lys Leu Leu Ala Leu Asp Glu Leu 
                245                 250                 255     


Ile Asp Ser Cys Glu Pro Thr Gln Val Lys His Met Met Gln Val Ile 
            260                 265                 270         


Glu Pro Gln Phe Gln Arg Asp Phe Ile Ser Leu Leu Pro Lys Glu Leu 
        275                 280                 285             


Ala Leu Tyr Val Leu Ser Phe Leu Glu Pro Lys Asp Leu Leu Gln Ala 
    290                 295                 300                 


Ala Gln Thr Cys Arg Tyr Trp Arg Ile Leu Ala Glu Asp Asn Leu Leu 
305                 310                 315                 320 


Trp Arg Glu Lys Cys Lys Glu Glu Gly Ile Asp Glu Pro Leu His Ile 
                325                 330                 335     


Lys Arg Arg Lys Val Ile Lys Pro Gly Phe Ile His Ser Pro Trp Lys 
            340                 345                 350         


Ser Ala Tyr Ile Arg Gln His Arg Ile Asp Thr Asn Trp Arg Arg Gly 
        355                 360                 365             


Glu Leu Lys Ser Pro Lys Val Leu Lys Gly His Asp Asp His Val Ile 
    370                 375                 380                 


Thr Cys Leu Gln Phe Cys Gly Asn Arg Ile Val Ser Gly Ser Asp Asp 
385                 390                 395                 400 


Asn Thr Leu Lys Val Trp Ser Ala Val Thr Gly Lys Cys Leu Arg Thr 
                405                 410                 415     


Leu Val Gly His Thr Gly Gly Val Trp Ser Ser Gln Met Arg Asp Asn 
            420                 425                 430         


Ile Ile Ile Ser Gly Ser Thr Asp Arg Thr Leu Lys Val Trp Asn Ala 
        435                 440                 445             


Glu Thr Gly Glu Cys Ile His Thr Leu Tyr Gly His Thr Ser Thr Val 
    450                 455                 460                 


Arg Cys Met His Leu His Glu Lys Arg Val Val Ser Gly Ser Arg Asp 
465                 470                 475                 480 


Ala Thr Leu Arg Val Trp Asp Ile Glu Thr Gly Gln Cys Leu His Val 
                485                 490                 495     


Leu Met Gly His Val Ala Ala Val Arg Cys Val Gln Tyr Asp Gly Arg 
            500                 505                 510         


Arg Val Val Ser Gly Ala Tyr Asp Phe Met Val Lys Val Trp Asp Pro 
        515                 520                 525             


Glu Thr Glu Thr Cys Leu His Thr Leu Gln Gly His Thr Asn Arg Val 
    530                 535                 540                 


Tyr Ser Leu Gln Phe Asp Gly Ile His Val Val Ser Gly Ser Leu Asp 
545                 550                 555                 560 


Thr Ser Ile Arg Val Trp Asp Val Glu Thr Gly Asn Cys Ile His Thr 
                565                 570                 575     


Leu Thr Gly His Gln Ser Leu Thr Ser Gly Met Glu Leu Lys Asp Asn 
            580                 585                 590         


Ile Leu Val Ser Gly Asn Ala Asp Ser Thr Val Lys Ile Trp Asp Ile 
        595                 600                 605             


Lys Thr Gly Gln Cys Leu Gln Thr Leu Gln Gly Pro Asn Lys His Gln 
    610                 615                 620                 


Ser Ala Val Thr Cys Leu Gln Phe Asn Lys Asn Phe Val Ile Thr Ser 
625                 630                 635                 640 


Ser Asp Asp Gly Thr Val Lys Leu Trp Asp Leu Lys Thr Gly Glu Phe 
                645                 650                 655     


Ile Arg Asn Leu Val Thr Leu Glu Ser Gly Gly Ser Gly Gly Val Val 
            660                 665                 670         


Trp Arg Ile Arg Ala Ser Asn Thr Lys Leu Val Cys Ala Val Gly Ser 
        675                 680                 685             


Arg Asn Gly Thr Glu Glu Thr Lys Leu Leu Val Leu Asp Phe Asp Val 
    690                 695                 700                 


Asp Met Lys 
705         


<210>  5176
<211>  176
<212>  PRT
<213>  Homo Sapiens

<400>  5176

Met Asn Gln Glu Leu Leu Ser Val Gly Ser Lys Arg Arg Arg Thr Gly 
1               5                   10                  15      


Gly Ser Leu Arg Gly Asn Pro Ser Ser Ser Gln Val Asp Glu Glu Gln 
            20                  25                  30          


Met Asn Arg Val Val Glu Glu Glu Gln Gln Gln Gln Leu Arg Gln Gln 
        35                  40                  45              


Glu Glu Glu His Thr Ala Arg Asn Gly Glu Val Val Gly Val Glu Pro 
    50                  55                  60                  


Arg Pro Gly Gly Gln Asn Asp Ser Gln Gln Gly Gln Leu Glu Glu Asn 
65                  70                  75                  80  


Asn Asn Arg Phe Ile Ser Val Asp Glu Asp Ser Ser Gly Asn Gln Glu 
                85                  90                  95      


Glu Gln Glu Glu Asp Glu Glu His Ala Gly Glu Gln Asp Glu Glu Asp 
            100                 105                 110         


Glu Glu Glu Glu Glu Met Asp Gln Glu Ser Asp Asp Phe Asp Gln Ser 
        115                 120                 125             


Asp Asp Ser Ser Arg Glu Asp Glu His Thr His Thr Asn Ser Val Thr 
    130                 135                 140                 


Asn Ser Ser Ser Ile Val Asp Leu Pro Val His Gln Leu Ser Ser Pro 
145                 150                 155                 160 


Phe Tyr Thr Lys Thr Thr Lys Val Ser Ile Phe Asn Ile Leu Leu Thr 
                165                 170                 175     


<210>  5177
<211>  589
<212>  PRT
<213>  Homo Sapiens

<400>  5177

Met Ser Lys Pro Gly Lys Pro Thr Leu Asn His Gly Leu Val Pro Val 
1               5                   10                  15      


Asp Leu Lys Ser Ala Lys Glu Pro Leu Pro His Gln Thr Val Met Lys 
            20                  25                  30          


Ile Phe Ser Ile Ser Ile Ile Ala Gln Gly Leu Pro Phe Cys Arg Arg 
        35                  40                  45              


Arg Met Lys Arg Lys Leu Asp His Gly Ser Glu Val Arg Ser Phe Ser 
    50                  55                  60                  


Leu Gly Lys Lys Pro Cys Lys Val Ser Glu Tyr Thr Ser Thr Thr Gly 
65                  70                  75                  80  


Leu Val Pro Cys Ser Ala Thr Pro Thr Thr Phe Gly Asp Leu Arg Ala 
                85                  90                  95      


Ala Asn Gly Gln Gly Gln Gln Arg Arg Arg Ile Thr Ser Val Gln Pro 
            100                 105                 110         


Pro Thr Gly Leu Gln Glu Trp Leu Lys Met Phe Gln Ser Trp Ser Gly 
        115                 120                 125             


Pro Glu Lys Leu Leu Ala Leu Asp Glu Leu Ile Asp Ser Cys Glu Pro 
    130                 135                 140                 


Thr Gln Val Lys His Met Met Gln Val Ile Glu Pro Gln Phe Gln Arg 
145                 150                 155                 160 


Asp Phe Ile Ser Leu Leu Pro Lys Glu Leu Ala Leu Tyr Val Leu Ser 
                165                 170                 175     


Phe Leu Glu Pro Lys Asp Leu Leu Gln Ala Ala Gln Thr Cys Arg Tyr 
            180                 185                 190         


Trp Arg Ile Leu Ala Glu Asp Asn Leu Leu Trp Arg Glu Lys Cys Lys 
        195                 200                 205             


Glu Glu Gly Ile Asp Glu Pro Leu His Ile Lys Arg Arg Lys Val Ile 
    210                 215                 220                 


Lys Pro Gly Phe Ile His Ser Pro Trp Lys Ser Ala Tyr Ile Arg Gln 
225                 230                 235                 240 


His Arg Ile Asp Thr Asn Trp Arg Arg Gly Glu Leu Lys Ser Pro Lys 
                245                 250                 255     


Val Leu Lys Gly His Asp Asp His Val Ile Thr Cys Leu Gln Phe Cys 
            260                 265                 270         


Gly Asn Arg Ile Val Ser Gly Ser Asp Asp Asn Thr Leu Lys Val Trp 
        275                 280                 285             


Ser Ala Val Thr Gly Lys Cys Leu Arg Thr Leu Val Gly His Thr Gly 
    290                 295                 300                 


Gly Val Trp Ser Ser Gln Met Arg Asp Asn Ile Ile Ile Ser Gly Ser 
305                 310                 315                 320 


Thr Asp Arg Thr Leu Lys Val Trp Asn Ala Glu Thr Gly Glu Cys Ile 
                325                 330                 335     


His Thr Leu Tyr Gly His Thr Ser Thr Val Arg Cys Met His Leu His 
            340                 345                 350         


Glu Lys Arg Val Val Ser Gly Ser Arg Asp Ala Thr Leu Arg Val Trp 
        355                 360                 365             


Asp Ile Glu Thr Gly Gln Cys Leu His Val Leu Met Gly His Val Ala 
    370                 375                 380                 


Ala Val Arg Cys Val Gln Tyr Asp Gly Arg Arg Val Val Ser Gly Ala 
385                 390                 395                 400 


Tyr Asp Phe Met Val Lys Val Trp Asp Pro Glu Thr Glu Thr Cys Leu 
                405                 410                 415     


His Thr Leu Gln Gly His Thr Asn Arg Val Tyr Ser Leu Gln Phe Asp 
            420                 425                 430         


Gly Ile His Val Val Ser Gly Ser Leu Asp Thr Ser Ile Arg Val Trp 
        435                 440                 445             


Asp Val Glu Thr Gly Asn Cys Ile His Thr Leu Thr Gly His Gln Ser 
    450                 455                 460                 


Leu Thr Ser Gly Met Glu Leu Lys Asp Asn Ile Leu Val Ser Gly Asn 
465                 470                 475                 480 


Ala Asp Ser Thr Val Lys Ile Trp Asp Ile Lys Thr Gly Gln Cys Leu 
                485                 490                 495     


Gln Thr Leu Gln Gly Pro Asn Lys His Gln Ser Ala Val Thr Cys Leu 
            500                 505                 510         


Gln Phe Asn Lys Asn Phe Val Ile Thr Ser Ser Asp Asp Gly Thr Val 
        515                 520                 525             


Lys Leu Trp Asp Leu Lys Thr Gly Glu Phe Ile Arg Asn Leu Val Thr 
    530                 535                 540                 


Leu Glu Ser Gly Gly Ser Gly Gly Val Val Trp Arg Ile Arg Ala Ser 
545                 550                 555                 560 


Asn Thr Lys Leu Val Cys Ala Val Gly Ser Arg Asn Gly Thr Glu Glu 
                565                 570                 575     


Thr Lys Leu Leu Val Leu Asp Phe Asp Val Asp Met Lys 
            580                 585                 


<210>  5178
<211>  179
<212>  PRT
<213>  Homo Sapiens

<400>  5178

Met Asp Pro Lys Gln Thr Thr Leu Leu Cys Leu Gly Asp Phe Pro Met 
1               5                   10                  15      


Pro Phe Ile Ser Ala Lys Ser Ser Pro Val Ile Pro Leu Asp Gly Ser 
            20                  25                  30          


Val Lys Ile Gln Cys Gln Ala Ile Arg Glu Ala Tyr Leu Thr Gln Leu 
        35                  40                  45              


Met Ile Ile Lys Asn Ser Thr Tyr Arg Glu Ile Gly Arg Arg Leu Lys 
    50                  55                  60                  


Phe Trp Asn Glu Thr Asp Pro Glu Phe Val Ile Asp His Met Asp Ala 
65                  70                  75                  80  


Asn Lys Ala Gly Arg Tyr Gln Cys Gln Tyr Arg Ile Gly His Tyr Arg 
                85                  90                  95      


Phe Arg Tyr Ser Asp Thr Leu Glu Leu Val Val Thr Asp Ser Ile His 
            100                 105                 110         


Gln Asp Tyr Thr Thr Gln Asn Leu Ile Arg Met Ala Val Ala Gly Leu 
        115                 120                 125             


Val Leu Val Ala Leu Leu Ala Ile Leu Val Glu Asn Trp His Ser His 
    130                 135                 140                 


Thr Ala Leu Asn Lys Glu Ala Ser Ala Asp Val Ala Glu Pro Ser Trp 
145                 150                 155                 160 


Ser Gln Gln Met Cys Gln Pro Gly Leu Thr Phe Ala Arg Thr Pro Ser 
                165                 170                 175     


Val Cys Lys 
            


<210>  5179
<211>  253
<212>  PRT
<213>  Homo Sapiens

<400>  5179

Met Asp Pro Lys Gln Thr Thr Leu Leu Cys Leu Gly Asp Phe Pro Met 
1               5                   10                  15      


Pro Phe Ile Ser Ala Lys Ser Ser Pro Val Ile Pro Leu Asp Gly Ser 
            20                  25                  30          


Val Lys Ile Gln Cys Gln Ala Ile Arg Glu Ala Tyr Leu Thr Gln Leu 
        35                  40                  45              


Met Ile Ile Lys Asn Ser Thr Tyr Arg Glu Ile Gly Arg Arg Leu Lys 
    50                  55                  60                  


Phe Trp Asn Glu Thr Asp Pro Glu Phe Val Ile Asp His Met Asp Ala 
65                  70                  75                  80  


Asn Lys Ala Gly Arg Tyr Gln Cys Gln Tyr Arg Ile Gly His Tyr Arg 
                85                  90                  95      


Phe Arg Tyr Ser Asp Thr Leu Glu Leu Val Val Thr Gly Leu Tyr Gly 
            100                 105                 110         


Lys Pro Phe Leu Ser Ala Asp Arg Gly Leu Val Leu Met Pro Gly Glu 
        115                 120                 125             


Asn Ile Ser Leu Thr Cys Ser Ser Ala His Ile Pro Phe Asp Arg Phe 
    130                 135                 140                 


Ser Leu Ala Lys Glu Gly Glu Leu Ser Leu Pro Gln His Gln Ser Gly 
145                 150                 155                 160 


Glu His Pro Ala Asn Phe Ser Leu Gly Pro Val Asp Leu Asn Val Ser 
                165                 170                 175     


Gly Ile Tyr Arg Cys Tyr Asp Ser Ile His Gln Asp Tyr Thr Thr Gln 
            180                 185                 190         


Asn Leu Ile Arg Met Ala Val Ala Gly Leu Val Leu Val Ala Leu Leu 
        195                 200                 205             


Ala Ile Leu Val Glu Asn Trp His Ser His Thr Ala Leu Asn Lys Glu 
    210                 215                 220                 


Ala Ser Ala Asp Val Ala Glu Pro Ser Trp Ser Gln Gln Met Cys Gln 
225                 230                 235                 240 


Pro Gly Leu Thr Phe Ala Arg Thr Pro Ser Val Cys Lys 
                245                 250             


<210>  5180
<211>  275
<212>  PRT
<213>  Homo Sapiens

<400>  5180

Met Asp Pro Lys Gln Thr Thr Leu Leu Cys Leu Gly Asp Phe Pro Met 
1               5                   10                  15      


Pro Phe Ile Ser Ala Lys Ser Ser Pro Val Ile Pro Leu Asp Gly Ser 
            20                  25                  30          


Val Lys Ile Gln Cys Gln Ala Ile Arg Glu Ala Tyr Leu Thr Gln Leu 
        35                  40                  45              


Met Ile Ile Lys Asn Ser Thr Tyr Arg Glu Ile Gly Arg Arg Leu Lys 
    50                  55                  60                  


Phe Trp Asn Glu Thr Asp Pro Glu Phe Val Ile Asp His Met Asp Ala 
65                  70                  75                  80  


Asn Lys Ala Gly Arg Tyr Gln Cys Gln Tyr Arg Ile Gly His Tyr Arg 
                85                  90                  95      


Phe Arg Tyr Ser Asp Thr Leu Glu Leu Val Val Thr Gly Leu Tyr Gly 
            100                 105                 110         


Lys Pro Phe Leu Ser Ala Asp Arg Gly Leu Val Leu Met Pro Gly Glu 
        115                 120                 125             


Asn Ile Ser Leu Thr Cys Ser Ser Ala His Ile Pro Phe Asp Arg Phe 
    130                 135                 140                 


Ser Leu Ala Lys Glu Gly Glu Leu Ser Leu Pro Gln His Gln Ser Gly 
145                 150                 155                 160 


Glu His Pro Ala Asn Phe Ser Leu Gly Pro Val Asp Leu Asn Val Ser 
                165                 170                 175     


Gly Ile Tyr Arg Cys Tyr Gly Trp Tyr Asn Arg Ser Pro Tyr Leu Trp 
            180                 185                 190         


Ser Phe Pro Ser Asn Ala Leu Glu Leu Val Val Thr Asp Ser Ile His 
        195                 200                 205             


Gln Asp Tyr Thr Thr Gln Asn Leu Ile Arg Met Ala Val Ala Gly Leu 
    210                 215                 220                 


Val Leu Val Ala Leu Leu Ala Ile Leu Val Glu Asn Trp His Ser His 
225                 230                 235                 240 


Thr Ala Leu Asn Lys Glu Ala Ser Ala Asp Val Ala Glu Pro Ser Trp 
                245                 250                 255     


Ser Gln Gln Met Cys Gln Pro Gly Leu Thr Phe Ala Arg Thr Pro Ser 
            260                 265                 270         


Val Cys Lys 
        275 


<210>  5181
<211>  227
<212>  PRT
<213>  Homo Sapiens

<400>  5181

Met Asp Pro Lys Gln Thr Thr Leu Leu Cys Leu Gly Asp Phe Pro Met 
1               5                   10                  15      


Pro Phe Ile Ser Ala Lys Ser Ser Pro Val Ile Pro Leu Asp Gly Ser 
            20                  25                  30          


Val Lys Ile Gln Cys Gln Ala Ile Arg Glu Ala Tyr Leu Thr Gln Leu 
        35                  40                  45              


Met Ile Ile Lys Asn Ser Thr Tyr Arg Glu Ile Gly Arg Arg Leu Lys 
    50                  55                  60                  


Phe Trp Asn Glu Thr Asp Pro Glu Phe Val Ile Asp His Met Asp Ala 
65                  70                  75                  80  


Asn Lys Ala Gly Arg Tyr Gln Cys Gln Tyr Arg Ile Gly His Tyr Arg 
                85                  90                  95      


Phe Arg Tyr Ser Asp Thr Leu Glu Leu Val Val Thr Gly Leu Tyr Gly 
            100                 105                 110         


Lys Pro Phe Leu Ser Ala Asp Arg Gly Leu Val Leu Met Pro Gly Glu 
        115                 120                 125             


Asn Ile Ser Leu Thr Cys Ser Ser Ala His Ile Pro Phe Asp Arg Phe 
    130                 135                 140                 


Ser Leu Ala Lys Glu Gly Glu Leu Ser Leu Pro Gln His Gln Ser Gly 
145                 150                 155                 160 


Glu His Pro Ala Asn Phe Ser Leu Gly Pro Val Asp Leu Asn Val Ser 
                165                 170                 175     


Gly Ile Tyr Arg Cys Tyr Gly Trp Tyr Asn Arg Ser Pro Tyr Leu Trp 
            180                 185                 190         


Ser Phe Pro Ser Asn Ala Leu Glu Leu Val Val Thr Gly Arg Tyr Arg 
        195                 200                 205             


Pro Val Gln Pro Cys Val Trp Val Gly Cys Pro Gly Pro Cys His Arg 
    210                 215                 220                 


Ala Gly Ile 
225         


<210>  5182
<211>  209
<212>  PRT
<213>  Homo Sapiens

<400>  5182

Met Asp Pro Lys Gln Thr Thr Leu Leu Cys Leu Gly Asp Phe Pro Met 
1               5                   10                  15      


Pro Phe Ile Ser Ala Lys Ser Ser Pro Val Ile Pro Leu Asp Gly Ser 
            20                  25                  30          


Val Lys Ile Gln Cys Gln Ala Ile Arg Glu Ala Tyr Leu Thr Gln Leu 
        35                  40                  45              


Met Ile Ile Lys Asn Ser Thr Tyr Arg Glu Ile Gly Arg Arg Leu Lys 
    50                  55                  60                  


Phe Trp Asn Glu Thr Asp Pro Glu Phe Val Ile Asp His Met Asp Ala 
65                  70                  75                  80  


Asn Lys Ala Gly Arg Tyr Gln Cys Gln Tyr Arg Ile Gly His Tyr Arg 
                85                  90                  95      


Phe Arg Tyr Ser Asp Thr Leu Glu Leu Val Val Thr Gly Leu Tyr Gly 
            100                 105                 110         


Lys Pro Phe Leu Ser Ala Asp Arg Gly Leu Val Leu Met Pro Gly Glu 
        115                 120                 125             


Asn Ile Ser Leu Thr Cys Ser Ser Ala His Ile Pro Phe Asp Arg Phe 
    130                 135                 140                 


Ser Leu Ala Lys Glu Gly Glu Leu Ser Leu Pro Gln His Gln Ser Gly 
145                 150                 155                 160 


Glu His Pro Ala Asn Phe Ser Leu Gly Pro Val Asp Leu Asn Val Ser 
                165                 170                 175     


Gly Ile Tyr Arg Leu His Pro Pro Arg Leu His Asp Ala Glu Leu Asp 
            180                 185                 190         


Pro His Gly Arg Gly Arg Thr Gly Pro Arg Gly Ser Leu Gly His Thr 
        195                 200                 205             


Gly 
    


<210>  5183
<211>  178
<212>  PRT
<213>  Homo Sapiens

<400>  5183

Met Asp Pro Lys Gln Thr Thr Leu Leu Cys Leu Gly Leu Tyr Gly Lys 
1               5                   10                  15      


Pro Phe Leu Ser Ala Asp Arg Gly Leu Val Leu Met Pro Gly Glu Asn 
            20                  25                  30          


Ile Ser Leu Thr Cys Ser Ser Ala His Ile Pro Phe Asp Arg Phe Ser 
        35                  40                  45              


Leu Ala Lys Glu Gly Glu Leu Ser Leu Pro Gln His Gln Ser Gly Glu 
    50                  55                  60                  


His Pro Ala Asn Phe Ser Leu Gly Pro Val Asp Leu Asn Val Ser Gly 
65                  70                  75                  80  


Ile Tyr Arg Cys Tyr Gly Trp Tyr Asn Arg Ser Pro Tyr Leu Trp Ser 
                85                  90                  95      


Phe Pro Ser Asn Ala Leu Glu Leu Val Val Thr Asp Ser Ile His Gln 
            100                 105                 110         


Asp Tyr Thr Thr Gln Asn Leu Ile Arg Met Ala Val Ala Gly Leu Val 
        115                 120                 125             


Leu Val Ala Leu Leu Ala Ile Leu Val Glu Asn Trp His Ser His Thr 
    130                 135                 140                 


Ala Leu Asn Lys Glu Ala Ser Ala Asp Val Ala Glu Pro Ser Trp Ser 
145                 150                 155                 160 


Gln Gln Met Cys Gln Pro Gly Leu Thr Phe Ala Arg Thr Pro Ser Val 
                165                 170                 175     


Cys Lys 
        


<210>  5184
<211>  191
<212>  PRT
<213>  Homo Sapiens

<400>  5184

Met Asp Pro Lys Gln Thr Thr Leu Leu Cys Leu Val Leu Cys Leu Gly 
1               5                   10                  15      


Gln Arg Ile Gln Ala Gln Glu Gly Asp Phe Pro Met Pro Phe Ile Ser 
            20                  25                  30          


Ala Lys Ser Ser Pro Val Ile Pro Leu Asp Gly Ser Val Lys Ile Gln 
        35                  40                  45              


Cys Gln Ala Ile Arg Glu Ala Tyr Leu Thr Gln Leu Met Ile Ile Lys 
    50                  55                  60                  


Asn Ser Thr Tyr Arg Glu Ile Gly Arg Arg Leu Lys Phe Trp Asn Glu 
65                  70                  75                  80  


Thr Asp Pro Glu Phe Val Ile Asp His Met Asp Ala Asn Lys Ala Gly 
                85                  90                  95      


Arg Tyr Gln Cys Gln Tyr Arg Ile Gly His Tyr Arg Phe Arg Tyr Ser 
            100                 105                 110         


Asp Thr Leu Glu Leu Val Val Thr Asp Ser Ile His Gln Asp Tyr Thr 
        115                 120                 125             


Thr Gln Asn Leu Ile Arg Met Ala Val Ala Gly Leu Val Leu Val Ala 
    130                 135                 140                 


Leu Leu Ala Ile Leu Val Glu Asn Trp His Ser His Thr Ala Leu Asn 
145                 150                 155                 160 


Lys Glu Ala Ser Ala Asp Val Ala Glu Pro Ser Trp Ser Gln Gln Met 
                165                 170                 175     


Cys Gln Pro Gly Leu Thr Phe Ala Arg Thr Pro Ser Val Cys Lys 
            180                 185                 190     


<210>  5185
<211>  265
<212>  PRT
<213>  Homo Sapiens

<400>  5185

Met Asp Pro Lys Gln Thr Thr Leu Leu Cys Leu Val Leu Cys Leu Gly 
1               5                   10                  15      


Gln Arg Ile Gln Ala Gln Glu Gly Asp Phe Pro Met Pro Phe Ile Ser 
            20                  25                  30          


Ala Lys Ser Ser Pro Val Ile Pro Leu Asp Gly Ser Val Lys Ile Gln 
        35                  40                  45              


Cys Gln Ala Ile Arg Glu Ala Tyr Leu Thr Gln Leu Met Ile Ile Lys 
    50                  55                  60                  


Asn Ser Thr Tyr Arg Glu Ile Gly Arg Arg Leu Lys Phe Trp Asn Glu 
65                  70                  75                  80  


Thr Asp Pro Glu Phe Val Ile Asp His Met Asp Ala Asn Lys Ala Gly 
                85                  90                  95      


Arg Tyr Gln Cys Gln Tyr Arg Ile Gly His Tyr Arg Phe Arg Tyr Ser 
            100                 105                 110         


Asp Thr Leu Glu Leu Val Val Thr Gly Leu Tyr Gly Lys Pro Phe Leu 
        115                 120                 125             


Ser Ala Asp Arg Gly Leu Val Leu Met Pro Gly Glu Asn Ile Ser Leu 
    130                 135                 140                 


Thr Cys Ser Ser Ala His Ile Pro Phe Asp Arg Phe Ser Leu Ala Lys 
145                 150                 155                 160 


Glu Gly Glu Leu Ser Leu Pro Gln His Gln Ser Gly Glu His Pro Ala 
                165                 170                 175     


Asn Phe Ser Leu Gly Pro Val Asp Leu Asn Val Ser Gly Ile Tyr Arg 
            180                 185                 190         


Cys Tyr Asp Ser Ile His Gln Asp Tyr Thr Thr Gln Asn Leu Ile Arg 
        195                 200                 205             


Met Ala Val Ala Gly Leu Val Leu Val Ala Leu Leu Ala Ile Leu Val 
    210                 215                 220                 


Glu Asn Trp His Ser His Thr Ala Leu Asn Lys Glu Ala Ser Ala Asp 
225                 230                 235                 240 


Val Ala Glu Pro Ser Trp Ser Gln Gln Met Cys Gln Pro Gly Leu Thr 
                245                 250                 255     


Phe Ala Arg Thr Pro Ser Val Cys Lys 
            260                 265 


<210>  5186
<211>  287
<212>  PRT
<213>  Homo Sapiens

<400>  5186

Met Asp Pro Lys Gln Thr Thr Leu Leu Cys Leu Val Leu Cys Leu Gly 
1               5                   10                  15      


Gln Arg Ile Gln Ala Gln Glu Gly Asp Phe Pro Met Pro Phe Ile Ser 
            20                  25                  30          


Ala Lys Ser Ser Pro Val Ile Pro Leu Asp Gly Ser Val Lys Ile Gln 
        35                  40                  45              


Cys Gln Ala Ile Arg Glu Ala Tyr Leu Thr Gln Leu Met Ile Ile Lys 
    50                  55                  60                  


Asn Ser Thr Tyr Arg Glu Ile Gly Arg Arg Leu Lys Phe Trp Asn Glu 
65                  70                  75                  80  


Thr Asp Pro Glu Phe Val Ile Asp His Met Asp Ala Asn Lys Ala Gly 
                85                  90                  95      


Arg Tyr Gln Cys Gln Tyr Arg Ile Gly His Tyr Arg Phe Arg Tyr Ser 
            100                 105                 110         


Asp Thr Leu Glu Leu Val Val Thr Gly Leu Tyr Gly Lys Pro Phe Leu 
        115                 120                 125             


Ser Ala Asp Arg Gly Leu Val Leu Met Pro Gly Glu Asn Ile Ser Leu 
    130                 135                 140                 


Thr Cys Ser Ser Ala His Ile Pro Phe Asp Arg Phe Ser Leu Ala Lys 
145                 150                 155                 160 


Glu Gly Glu Leu Ser Leu Pro Gln His Gln Ser Gly Glu His Pro Ala 
                165                 170                 175     


Asn Phe Ser Leu Gly Pro Val Asp Leu Asn Val Ser Gly Ile Tyr Arg 
            180                 185                 190         


Cys Tyr Gly Trp Tyr Asn Arg Ser Pro Tyr Leu Trp Ser Phe Pro Ser 
        195                 200                 205             


Asn Ala Leu Glu Leu Val Val Thr Asp Ser Ile His Gln Asp Tyr Thr 
    210                 215                 220                 


Thr Gln Asn Leu Ile Arg Met Ala Val Ala Gly Leu Val Leu Val Ala 
225                 230                 235                 240 


Leu Leu Ala Ile Leu Val Glu Asn Trp His Ser His Thr Ala Leu Asn 
                245                 250                 255     


Lys Glu Ala Ser Ala Asp Val Ala Glu Pro Ser Trp Ser Gln Gln Met 
            260                 265                 270         


Cys Gln Pro Gly Leu Thr Phe Ala Arg Thr Pro Ser Val Cys Lys 
        275                 280                 285         


<210>  5187
<211>  239
<212>  PRT
<213>  Homo Sapiens

<400>  5187

Met Asp Pro Lys Gln Thr Thr Leu Leu Cys Leu Val Leu Cys Leu Gly 
1               5                   10                  15      


Gln Arg Ile Gln Ala Gln Glu Gly Asp Phe Pro Met Pro Phe Ile Ser 
            20                  25                  30          


Ala Lys Ser Ser Pro Val Ile Pro Leu Asp Gly Ser Val Lys Ile Gln 
        35                  40                  45              


Cys Gln Ala Ile Arg Glu Ala Tyr Leu Thr Gln Leu Met Ile Ile Lys 
    50                  55                  60                  


Asn Ser Thr Tyr Arg Glu Ile Gly Arg Arg Leu Lys Phe Trp Asn Glu 
65                  70                  75                  80  


Thr Asp Pro Glu Phe Val Ile Asp His Met Asp Ala Asn Lys Ala Gly 
                85                  90                  95      


Arg Tyr Gln Cys Gln Tyr Arg Ile Gly His Tyr Arg Phe Arg Tyr Ser 
            100                 105                 110         


Asp Thr Leu Glu Leu Val Val Thr Gly Leu Tyr Gly Lys Pro Phe Leu 
        115                 120                 125             


Ser Ala Asp Arg Gly Leu Val Leu Met Pro Gly Glu Asn Ile Ser Leu 
    130                 135                 140                 


Thr Cys Ser Ser Ala His Ile Pro Phe Asp Arg Phe Ser Leu Ala Lys 
145                 150                 155                 160 


Glu Gly Glu Leu Ser Leu Pro Gln His Gln Ser Gly Glu His Pro Ala 
                165                 170                 175     


Asn Phe Ser Leu Gly Pro Val Asp Leu Asn Val Ser Gly Ile Tyr Arg 
            180                 185                 190         


Cys Tyr Gly Trp Tyr Asn Arg Ser Pro Tyr Leu Trp Ser Phe Pro Ser 
        195                 200                 205             


Asn Ala Leu Glu Leu Val Val Thr Gly Arg Tyr Arg Pro Val Gln Pro 
    210                 215                 220                 


Cys Val Trp Val Gly Cys Pro Gly Pro Cys His Arg Ala Gly Ile 
225                 230                 235                 


<210>  5188
<211>  1642
<212>  PRT
<213>  Homo Sapiens

<400>  5188

Cys Pro Pro His Ser His Tyr Glu Ala Cys Ser Tyr Gly Cys Pro Leu 
1               5                   10                  15      


Ser Cys Gly Asp Leu Pro Val Pro Glu Gly Cys Glu Ser Ala Cys Arg 
            20                  25                  30          


Glu Gly Cys Val Cys Asp Ala Gly Phe Val Leu Ser Gly Asp Thr Cys 
        35                  40                  45              


Val Pro Val Gly Gln Cys Gly Cys Leu His Asp Asp Arg Tyr Tyr Pro 
    50                  55                  60                  


Leu Gly Gln Thr Phe Tyr Pro Gly Pro Gly Cys Asp Ser Leu Cys Arg 
65                  70                  75                  80  


Cys Arg Glu Gly Gly Glu Val Ser Cys Glu Pro Ser Ser Cys Gly Pro 
                85                  90                  95      


His Glu Thr Cys Arg Pro Ser Gly Gly Ser Leu Gly Cys Val Ala Val 
            100                 105                 110         


Gly Ser Thr Thr Cys Gln Ala Ser Gly Asp Pro His Tyr Thr Thr Phe 
        115                 120                 125             


Asp Gly His Arg Phe Asp Phe Met Gly Thr Cys Val Tyr Val Leu Ala 
    130                 135                 140                 


Gln Thr Cys Gly Thr Arg Pro Gly Leu His Arg Phe Ala Val Leu Gln 
145                 150                 155                 160 


Glu Asn Val Ala Trp Gly Asn Gly Arg Val Ser Val Thr Arg Val Ile 
                165                 170                 175     


Thr Val Gln Val Ala Asn Phe Thr Leu Arg Leu Glu Gln Arg Gln Trp 
            180                 185                 190         


Lys Val Thr Val Asn Gly Val Asp Met Lys Leu Pro Val Val Leu Ala 
        195                 200                 205             


Asn Gly Gln Ile Arg Ala Ser Gln His Gly Ser Asp Val Val Ile Glu 
    210                 215                 220                 


Thr Asp Phe Gly Leu Arg Val Ala Tyr Asp Leu Val Tyr Tyr Val Arg 
225                 230                 235                 240 


Val Thr Val Pro Gly Asn Tyr Tyr Gln Leu Met Cys Gly Leu Cys Gly 
                245                 250                 255     


Asn Tyr Asn Gly Asp Pro Lys Asp Asp Phe Gln Lys Pro Asn Gly Ser 
            260                 265                 270         


Gln Ala Gly Asn Ala Asn Glu Phe Gly Asn Ser Trp Glu Glu Val Val 
        275                 280                 285             


Ser Asp Ser Pro Cys Leu Pro Pro Pro Thr Cys Pro Pro Gly Ser Glu 
    290                 295                 300                 


Gly Cys Ile Pro Ser Glu Glu Cys Pro Pro Glu Leu Glu Lys Lys Tyr 
305                 310                 315                 320 


Gln Lys Glu Glu Phe Cys Gly Leu Leu Ser Ser Pro Thr Gly Pro Leu 
                325                 330                 335     


Ser Ser Cys His Lys Leu Val Asp Pro Gln Gly Pro Leu Lys Asp Cys 
            340                 345                 350         


Ile Phe Asp Leu Cys Leu Gly Gly Gly Asn Leu Ser Ile Leu Cys Ser 
        355                 360                 365             


Asn Ile His Ala Tyr Val Ser Ala Cys Gln Val Ala Gly Gly His Val 
    370                 375                 380                 


Glu Pro Trp Arg Asn Glu Thr Phe Cys Pro Met Glu Cys Pro Gln Asn 
385                 390                 395                 400 


Ser His Tyr Glu Leu Cys Ala Asp Thr Cys Ser Leu Gly Cys Ser Ala 
                405                 410                 415     


Leu Ser Ala Pro Leu Gln Cys Pro Asp Gly Cys Ala Glu Gly Cys Gln 
            420                 425                 430         


Cys Asp Ser Gly Phe Leu Tyr Asn Gly Gln Ala Cys Val Pro Ile Gln 
        435                 440                 445             


Gln Cys Gly Cys Tyr His Asn Gly Ala Tyr Tyr Glu Pro Glu Gln Thr 
    450                 455                 460                 


Val Leu Ile Asp Asn Cys Arg Gln Gln Cys Thr Cys His Ala Gly Lys 
465                 470                 475                 480 


Val Val Val Cys Gln Glu His Ser Cys Lys Pro Gly Gln Val Cys Gln 
                485                 490                 495     


Pro Ser Gly Gly Ile Leu Ser Cys Val Thr Lys Asp Pro Cys His Gly 
            500                 505                 510         


Val Thr Cys Arg Pro Gln Glu Thr Cys Lys Glu Gln Gly Gly Gln Gly 
        515                 520                 525             


Val Cys Leu Pro Asn Tyr Glu Ala Thr Cys Trp Leu Trp Gly Asp Pro 
    530                 535                 540                 


His Tyr His Ser Phe Asp Gly Arg Lys Phe Asp Phe Gln Gly Thr Cys 
545                 550                 555                 560 


Asn Tyr Val Leu Ala Thr Thr Gly Cys Pro Gly Val Ser Thr Gln Gly 
                565                 570                 575     


Leu Thr Pro Phe Thr Val Thr Thr Lys Asn Gln Asn Arg Gly Asn Pro 
            580                 585                 590         


Ala Val Ser Tyr Val Arg Val Val Thr Val Ala Ala Leu Gly Thr Asn 
        595                 600                 605             


Ile Ser Ile His Lys Asp Glu Ile Gly Lys Val Arg Val Asn Gly Val 
    610                 615                 620                 


Leu Thr Ala Leu Pro Val Ser Val Ala Asp Gly Arg Ile Ser Val Thr 
625                 630                 635                 640 


Gln Gly Ala Ser Lys Ala Leu Leu Val Ala Asp Phe Gly Leu Gln Val 
                645                 650                 655     


Ser Tyr Asp Trp Asn Trp Arg Val Asp Val Thr Leu Pro Ser Ser Tyr 
            660                 665                 670         


His Gly Ala Val Cys Gly Leu Cys Gly Asn Met Asp Arg Asn Pro Asn 
        675                 680                 685             


Asn Asp Gln Val Phe Pro Asn Gly Thr Leu Ala Pro Ser Ile Pro Ile 
    690                 695                 700                 


Trp Gly Gly Ser Trp Arg Ala Pro Gly Trp Asp Pro Leu Cys Trp Asp 
705                 710                 715                 720 


Glu Cys Arg Gly Ser Cys Pro Thr Cys Pro Glu Asp Arg Leu Glu Gln 
                725                 730                 735     


Tyr Glu Gly Pro Gly Phe Cys Gly Pro Leu Ala Pro Gly Thr Gly Gly 
            740                 745                 750         


Pro Phe Thr Thr Cys His Ala His Val Pro Pro Glu Ser Phe Phe Lys 
        755                 760                 765             


Gly Cys Val Leu Asp Val Cys Met Gly Gly Gly Asp Arg Asp Ile Leu 
    770                 775                 780                 


Cys Lys Ala Leu Ala Ser Tyr Val Ala Ala Cys Gln Ala Ala Gly Val 
785                 790                 795                 800 


Val Ile Glu Asp Trp Arg Ala Gln Val Gly Cys Glu Ile Thr Cys Pro 
                805                 810                 815     


Glu Asn Ser His Tyr Glu Val Cys Gly Pro Pro Cys Pro Ala Ser Cys 
            820                 825                 830         


Pro Ser Pro Ala Pro Leu Thr Thr Pro Ala Val Cys Glu Gly Pro Cys 
        835                 840                 845             


Val Glu Gly Cys Gln Cys Asp Ala Gly Phe Val Leu Ser Ala Asp Arg 
    850                 855                 860                 


Cys Val Pro Leu Asn Asn Gly Cys Gly Cys Trp Ala Asn Gly Thr Tyr 
865                 870                 875                 880 


His Glu Ala Gly Ser Glu Phe Trp Ala Asp Gly Thr Cys Ser Gln Trp 
                885                 890                 895     


Cys Arg Cys Gly Pro Gly Gly Gly Ser Leu Val Cys Thr Pro Ala Ser 
            900                 905                 910         


Cys Gly Leu Gly Glu Val Cys Gly Leu Leu Pro Ser Gly Gln His Gly 
        915                 920                 925             


Cys Gln Pro Val Ser Thr Ala Glu Cys Gln Ala Trp Gly Asp Pro His 
    930                 935                 940                 


Tyr Val Thr Leu Asp Gly His Arg Phe Asp Phe Gln Gly Thr Cys Glu 
945                 950                 955                 960 


Tyr Leu Leu Ser Ala Pro Cys His Gly Pro Pro Leu Gly Ala Glu Asn 
                965                 970                 975     


Phe Thr Val Thr Val Ala Asn Glu His Arg Gly Ser Gln Ala Val Ser 
            980                 985                 990         


Tyr Thr Arg Ser Val Thr Leu Gln  Ile Tyr Asn His Ser  Leu Thr Leu 
        995                 1000                 1005             


Ser Ala  Arg Trp Pro Arg Lys  Leu Gln Val Asp Gly  Val Phe Val 
    1010                 1015                 1020             


Thr Leu  Pro Phe Gln Leu Asp  Ser Leu Leu His Ala  His Leu Ser 
    1025                 1030                 1035             


Gly Ala  Asp Val Val Val Thr  Thr Thr Ser Gly Leu  Ser Leu Ala 
    1040                 1045                 1050             


Phe Asp  Gly Asp Ser Phe Val  Arg Leu Arg Val Pro  Ala Ala Tyr 
    1055                 1060                 1065             


Ala Gly  Ser Leu Cys Gly Leu  Cys Gly Asn Tyr Asn  Gln Asp Pro 
    1070                 1075                 1080             


Ala Asp  Asp Leu Lys Ala Val  Gly Gly Lys Pro Ala  Gly Trp Gln 
    1085                 1090                 1095             


Val Gly  Gly Ala Gln Gly Cys  Gly Glu Cys Val Ser  Lys Pro Cys 
    1100                 1105                 1110             


Pro Ser  Pro Cys Thr Pro Glu  Gln Gln Glu Ser Phe  Gly Gly Pro 
    1115                 1120                 1125             


Asp Ala  Cys Gly Val Ile Ser  Ala Thr Asp Gly Pro  Leu Ala Pro 
    1130                 1135                 1140             


Cys His  Gly Leu Val Pro Pro  Ala Gln Tyr Phe Gln  Gly Cys Leu 
    1145                 1150                 1155             


Leu Asp  Ala Cys Gln Val Gln  Gly His Pro Gly Gly  Leu Cys Pro 
    1160                 1165                 1170             


Ala Val  Ala Thr Tyr Val Ala  Ala Cys Gln Ala Ala  Gly Ala Gln 
    1175                 1180                 1185             


Leu Arg  Glu Trp Arg Arg Pro  Asp Phe Cys Pro Phe  Gln Cys Pro 
    1190                 1195                 1200             


Ala His  Ser His Tyr Glu Leu  Cys Gly Asp Ser Cys  Pro Gly Ser 
    1205                 1210                 1215             


Cys Pro  Ser Leu Ser Ala Pro  Glu Gly Cys Glu Ser  Ala Cys Arg 
    1220                 1225                 1230             


Glu Gly  Cys Val Cys Asp Ala  Gly Phe Val Leu Ser  Gly Asp Thr 
    1235                 1240                 1245             


Cys Val  Pro Val Gly Gln Cys  Gly Cys Leu His Asp  Asp Arg Tyr 
    1250                 1255                 1260             


Tyr Pro  Leu Gly Gln Thr Phe  Tyr Pro Gly Pro Gly  Cys Asp Ser 
    1265                 1270                 1275             


Leu Cys  Arg Cys Arg Glu Gly  Gly Glu Val Ser Cys  Glu Pro Ser 
    1280                 1285                 1290             


Ser Cys  Gly Pro His Glu Thr  Cys Arg Pro Ser Gly  Gly Ser Leu 
    1295                 1300                 1305             


Gly Cys  Val Ala Val Gly Ser  Thr Thr Cys Gln Ala  Ser Gly Asp 
    1310                 1315                 1320             


Pro His  Tyr Thr Thr Phe Asp  Gly His Arg Phe Asp  Phe Met Gly 
    1325                 1330                 1335             


Thr Cys  Val Tyr Val Leu Ala  Gln Thr Cys Gly Thr  Arg Pro Gly 
    1340                 1345                 1350             


Leu His  Arg Phe Ala Val Leu  Gln Glu Asn Val Ala  Trp Gly Asn 
    1355                 1360                 1365             


Gly Arg  Val Ser Val Thr Arg  Val Ile Thr Val Gln  Val Ala Asn 
    1370                 1375                 1380             


Phe Thr  Leu Arg Leu Glu Gln  Arg Gln Trp Lys Val  Thr Val Asn 
    1385                 1390                 1395             


Gly Val  Asp Met Lys Leu Pro  Val Val Leu Ala Asn  Gly Gln Ile 
    1400                 1405                 1410             


Arg Ala  Ser Gln His Gly Ser  Asp Val Val Ile Glu  Thr Asp Phe 
    1415                 1420                 1425             


Gly Leu  Arg Val Ala Tyr Asp  Leu Val Tyr Tyr Val  Arg Val Thr 
    1430                 1435                 1440             


Val Pro  Gly Asn Tyr Tyr Gln  Leu Met Cys Gly Leu  Cys Gly Asn 
    1445                 1450                 1455             


Tyr Asn  Gly Asp Pro Lys Asp  Asp Phe Gln Lys Pro  Asn Gly Ser 
    1460                 1465                 1470             


Gln Ala  Gly Asn Ala Asn Glu  Phe Gly Asn Ser Trp  Glu Glu Val 
    1475                 1480                 1485             


Val Pro  Asp Ser Pro Cys Leu  Pro Pro Pro Thr Cys  Pro Pro Gly 
    1490                 1495                 1500             


Ser Ala  Gly Cys Ile Pro Ser  Asp Lys Cys Pro Pro  Glu Leu Glu 
    1505                 1510                 1515             


Lys Lys  Tyr Gln Lys Glu Glu  Phe Cys Gly Leu Leu  Ser Ser Pro 
    1520                 1525                 1530             


Thr Gly  Pro Leu Ser Ser Cys  His Lys Leu Val Asp  Pro Gln Gly 
    1535                 1540                 1545             


Pro Leu  Lys Asp Cys Ile Phe  Asp Leu Cys Leu Gly  Gly Gly Asn 
    1550                 1555                 1560             


Leu Ser  Ile Leu Cys Ser Asn  Ile His Ala Tyr Val  Ser Ala Cys 
    1565                 1570                 1575             


Gln Ala  Ala Gly Gly His Val  Glu Pro Trp Arg Asn  Glu Thr Phe 
    1580                 1585                 1590             


Cys Pro  Met Glu Cys Pro Gln  Asn Ser His Tyr Glu  Leu Cys Ala 
    1595                 1600                 1605             


Asp Thr  Cys Ser Leu Gly Cys  Ser Ala Leu Ser Ala  Pro Leu Gln 
    1610                 1615                 1620             


Cys Pro  Asp Gly Cys Ala Glu  Gly Cys Gln Cys Asp  Ser Gly Phe 
    1625                 1630                 1635             


Leu Tyr  Asn Gly 
    1640         


<210>  5189
<211>  1132
<212>  PRT
<213>  Homo Sapiens

<400>  5189

Met Gly Ala Leu Trp Ser Trp Trp Ile Leu Trp Ala Gly Ala Thr Leu 
1               5                   10                  15      


Leu Trp Gly Leu Thr Gln Glu Ala Ser Val Asp Leu Lys Asn Thr Gly 
            20                  25                  30          


Arg Glu Glu Phe Leu Thr Ala Phe Leu Gln Asn Tyr Gln Leu Ala Tyr 
        35                  40                  45              


Ser Lys Ala Tyr Pro Arg Leu Leu Ile Ser Ser Leu Ser Glu Ser Pro 
    50                  55                  60                  


Ala Ser Val Ser Ile Leu Ser Gln Ala Asp Asn Thr Ser Lys Lys Val 
65                  70                  75                  80  


Thr Val Arg Pro Gly Glu Ser Val Met Val Asn Ile Ser Ala Lys Ala 
                85                  90                  95      


Glu Met Ile Gly Ser Lys Ile Phe Gln His Ala Val Val Ile His Ser 
            100                 105                 110         


Asp Tyr Ala Ile Ser Val Gln Ala Leu Asn Ala Lys Pro Asp Thr Ala 
        115                 120                 125             


Glu Leu Thr Leu Leu Arg Pro Ile Gln Ala Leu Gly Thr Glu Tyr Phe 
    130                 135                 140                 


Val Leu Thr Pro Pro Gly Thr Ser Ala Arg Asn Val Lys Glu Phe Ala 
145                 150                 155                 160 


Val Val Ala Gly Ala Ala Gly Ala Ser Val Ser Val Thr Leu Lys Gly 
                165                 170                 175     


Ser Val Thr Phe Asn Gly Lys Phe Tyr Pro Ala Gly Asp Val Leu Arg 
            180                 185                 190         


Val Thr Leu Gln Pro Tyr Asn Val Ala Gln Leu Gln Ser Ser Val Asp 
        195                 200                 205             


Leu Ser Gly Ser Lys Val Thr Ala Ser Ser Pro Val Ala Val Leu Ser 
    210                 215                 220                 


Gly His Ser Cys Ala Gln Lys His Thr Thr Cys Asn His Val Val Glu 
225                 230                 235                 240 


Gln Leu Leu Pro Thr Ser Ala Trp Gly Thr His Tyr Val Val Pro Thr 
                245                 250                 255     


Leu Ala Ser Gln Ser Arg Tyr Asp Leu Ala Phe Val Val Ala Ser Gln 
            260                 265                 270         


Ala Thr Lys Leu Thr Tyr Asn His Gly Gly Ile Thr Gly Ser Arg Gly 
        275                 280                 285             


Leu Gln Ala Gly Asp Val Val Glu Phe Glu Val Arg Pro Ser Trp Pro 
    290                 295                 300                 


Leu Tyr Leu Ser Ala Asn Val Gly Ile Gln Val Leu Leu Phe Gly Thr 
305                 310                 315                 320 


Gly Ala Ile Arg Asn Glu Val Thr Tyr Asp Pro Tyr Leu Val Leu Ile 
                325                 330                 335     


Pro Asp Val Ala Ala Tyr Cys Pro Ala Tyr Val Val Lys Ser Val Pro 
            340                 345                 350         


Gly Cys Glu Gly Val Ala Leu Val Val Ala Gln Thr Lys Ala Ile Ser 
        355                 360                 365             


Gly Leu Thr Ile Asp Gly His Ala Val Gly Ala Lys Leu Thr Trp Glu 
    370                 375                 380                 


Ala Val Pro Gly Ser Glu Phe Ser Tyr Ala Glu Val Glu Leu Gly Thr 
385                 390                 395                 400 


Ala Asp Met Ile His Thr Ala Glu Ala Thr Thr Asn Leu Gly Leu Leu 
                405                 410                 415     


Thr Phe Gly Leu Ala Lys Ala Ile Gly Tyr Ala Thr Ala Ala Asp Cys 
            420                 425                 430         


Gly Arg Thr Val Leu Ser Pro Val Glu Pro Ser Cys Glu Gly Met Gln 
        435                 440                 445             


Cys Ala Ala Gly Gln Arg Cys Gln Val Val Gly Gly Lys Ala Gly Cys 
    450                 455                 460                 


Val Ala Glu Ser Thr Ala Val Cys Arg Ala Gln Gly Asp Pro His Tyr 
465                 470                 475                 480 


Thr Thr Phe Asp Gly Arg Arg Tyr Asp Met Met Gly Thr Cys Ser Tyr 
                485                 490                 495     


Thr Met Val Glu Leu Cys Ser Glu Asp Asp Thr Leu Pro Ala Phe Ser 
            500                 505                 510         


Val Glu Ala Lys Asn Glu His Arg Gly Ser Arg Arg Val Ser Tyr Val 
        515                 520                 525             


Gly Leu Val Thr Val Arg Ala Tyr Ser His Ser Val Ser Leu Thr Arg 
    530                 535                 540                 


Gly Glu Val Gly Phe Val Leu Val Asp Asn Gln Arg Ser Arg Leu Pro 
545                 550                 555                 560 


Val Ser Leu Ser Glu Gly Arg Leu Arg Val Tyr Gln Ser Gly Pro Arg 
                565                 570                 575     


Ala Val Val Glu Leu Val Phe Gly Leu Val Val Thr Tyr Asp Trp Asp 
            580                 585                 590         


Cys Gln Leu Ala Leu Ser Leu Pro Ala Arg Phe Gln Asp Gln Val Cys 
        595                 600                 605             


Gly Leu Cys Gly Asn Tyr Asn Gly Asp Pro Ala Asp Asp Phe Leu Thr 
    610                 615                 620                 


Pro Asp Gly Ala Leu Ala Pro Asp Ala Val Glu Phe Ala Ser Ser Trp 
625                 630                 635                 640 


Lys Leu Asp Asp Gly Asp Tyr Leu Cys Glu Asp Gly Cys Gln Asn Asn 
                645                 650                 655     


Cys Pro Ala Cys Thr Pro Gly Gln Ala Gln His Tyr Glu Gly Asp Arg 
            660                 665                 670         


Leu Cys Gly Met Leu Thr Lys Leu Asp Gly Pro Phe Ala Val Cys His 
        675                 680                 685             


Asp Thr Leu Asp Pro Arg Pro Phe Leu Glu Gln Cys Val Tyr Asp Leu 
    690                 695                 700                 


Cys Val Val Gly Gly Glu Arg Leu Ser Leu Cys Arg Gly Leu Ser Ala 
705                 710                 715                 720 


Tyr Ala Gln Ala Cys Leu Glu Leu Gly Ile Ser Val Gly Asp Trp Arg 
                725                 730                 735     


Ser Pro Ala Asn Cys Pro Leu Ser Cys Pro Ala Asn Ser Arg Tyr Glu 
            740                 745                 750         


Leu Cys Gly Pro Ala Cys Pro Thr Ser Cys Asn Gly Ala Ala Ala Pro 
        755                 760                 765             


Ser Asn Cys Ser Gly Arg Pro Cys Val Glu Gly Cys Val Cys Leu Pro 
    770                 775                 780                 


Gly Phe Val Ala Ser Gly Gly Ala Cys Val Pro Ala Ser Ser Cys Gly 
785                 790                 795                 800 


Cys Thr Phe Gln Gly Leu Gln Leu Ala Pro Gly Gln Glu Val Trp Ala 
                805                 810                 815     


Asp Glu Leu Cys Gln Arg Arg Cys Thr Cys Asn Gly Ala Thr His Gln 
            820                 825                 830         


Val Thr Cys Arg Asp Lys Gln Ser Cys Pro Ala Gly Glu Arg Cys Ser 
        835                 840                 845             


Val Gln Asn Gly Leu Leu Gly Cys Tyr Pro Asp Arg Phe Gly Thr Cys 
    850                 855                 860                 


Gln Gly Ser Gly Asp Pro His Tyr Val Ser Phe Asp Gly Arg Arg Phe 
865                 870                 875                 880 


Asp Phe Met Gly Thr Cys Thr Tyr Leu Leu Val Gly Ser Cys Gly Gln 
                885                 890                 895     


Asn Ala Ala Leu Pro Ala Phe Arg Val Leu Val Glu Asn Glu His Arg 
            900                 905                 910         


Gly Ser Gln Thr Val Ser Tyr Thr Arg Ala Val Arg Val Glu Ala Arg 
        915                 920                 925             


Gly Val Lys Val Ala Val Arg Arg Glu Tyr Pro Gly Gln Val Leu Val 
    930                 935                 940                 


Asp Asp Val Leu Gln Tyr Leu Pro Phe Gln Ala Ala Asp Gly Gln Val 
945                 950                 955                 960 


Gln Val Phe Arg Gln Gly Arg Asp Ala Val Val Arg Thr Asp Phe Gly 
                965                 970                 975     


Leu Thr Val Thr Tyr Asp Trp Asn Ala Arg Val Thr Ala Lys Val Pro 
            980                 985                 990         


Ser Ser Tyr Ala Glu Ala Leu Cys  Gly Leu Cys Gly Asn  Phe Asn Gly 
        995                 1000                 1005             


Asp Pro  Ala Asp Asp Leu Ala  Leu Arg Gly Gly Gly  Gln Ala Ala 
    1010                 1015                 1020             


Asn Ala  Leu Ala Phe Gly Asn  Ser Trp Gln Glu Glu  Thr Arg Pro 
    1025                 1030                 1035             


Gly Cys  Gly Ala Thr Glu Pro  Gly Asp Cys Pro Lys  Leu Asp Ser 
    1040                 1045                 1050             


Leu Val  Ala Gln Gln Leu Gln  Ser Lys Asn Glu Cys  Gly Ile Leu 
    1055                 1060                 1065             


Ala Asp  Pro Lys Gly Pro Phe  Arg Glu Cys His Ser  Lys Leu Asp 
    1070                 1075                 1080             


Pro Gln  Gly Ala Val Arg Asp  Cys Val Tyr Asp Arg  Cys Leu Leu 
    1085                 1090                 1095             


Pro Gly  Gln Ser Gly Pro Leu  Cys Asp Ala Leu Ala  Thr Tyr Ala 
    1100                 1105                 1110             


Ala Ala  Cys Gln Ala Ala Gly  Ala Thr Val His Pro  Trp Arg Ser 
    1115                 1120                 1125             


Glu Glu  Leu Cys 
    1130         


<210>  5190
<211>  3072
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5190

Xaa Leu Ser Cys Pro Pro His Ser His Tyr Glu Ala Cys Ser Tyr Gly 
1               5                   10                  15      


Cys Pro Leu Ser Cys Gly Asp Leu Pro Val Pro Glu Gly Cys Glu Ser 
            20                  25                  30          


Ala Cys Arg Glu Gly Cys Val Cys Asp Ala Gly Phe Val Leu Ser Gly 
        35                  40                  45              


Asp Thr Cys Val Pro Val Gly Gln Cys Gly Cys Leu His Asp Asp Arg 
    50                  55                  60                  


Tyr Tyr Pro Leu Gly Gln Thr Phe Tyr Pro Gly Pro Gly Cys Asp Ser 
65                  70                  75                  80  


Leu Cys Arg Cys Arg Glu Gly Gly Glu Val Ser Cys Glu Pro Ser Ser 
                85                  90                  95      


Cys Gly Pro His Glu Thr Cys Arg Pro Ser Gly Gly Ser Leu Gly Cys 
            100                 105                 110         


Val Ala Val Gly Ser Thr Thr Cys Gln Ala Ser Gly Asp Pro His Tyr 
        115                 120                 125             


Thr Thr Phe Asp Gly His Arg Phe Asp Phe Met Gly Thr Cys Val Tyr 
    130                 135                 140                 


Val Leu Ala Gln Thr Cys Gly Thr Arg Pro Gly Leu His Arg Phe Ala 
145                 150                 155                 160 


Val Leu Gln Glu Asn Val Ala Trp Gly Asn Gly Arg Val Ser Val Thr 
                165                 170                 175     


Arg Val Ile Thr Val Gln Val Ala Asn Phe Thr Leu Arg Leu Glu Gln 
            180                 185                 190         


Arg Gln Trp Lys Val Thr Val Asn Gly Val Asp Met Lys Leu Pro Val 
        195                 200                 205             


Val Leu Ala Asn Gly Gln Ile Arg Ala Ser Gln His Gly Ser Asp Val 
    210                 215                 220                 


Val Ile Glu Thr Asp Phe Gly Leu Arg Val Ala Tyr Asp Leu Val Tyr 
225                 230                 235                 240 


Tyr Val Arg Val Thr Val Pro Gly Asn Tyr Tyr Gln Leu Met Cys Gly 
                245                 250                 255     


Leu Cys Gly Asn Tyr Asn Gly Asp Pro Lys Asp Asp Phe Gln Lys Pro 
            260                 265                 270         


Asn Gly Ser Gln Ala Gly Asn Ala Asn Glu Phe Gly Asn Ser Trp Glu 
        275                 280                 285             


Glu Val Val Ser Asp Ser Pro Cys Leu Pro Pro Pro Thr Cys Pro Pro 
    290                 295                 300                 


Gly Ser Glu Gly Cys Ile Pro Ser Glu Glu Cys Pro Pro Glu Leu Glu 
305                 310                 315                 320 


Lys Lys Tyr Gln Lys Glu Glu Phe Cys Gly Leu Leu Ser Ser Pro Thr 
                325                 330                 335     


Gly Pro Leu Ser Ser Cys His Lys Leu Val Asp Pro Gln Gly Pro Leu 
            340                 345                 350         


Lys Asp Cys Ile Phe Asp Leu Cys Leu Gly Gly Gly Asn Leu Ser Ile 
        355                 360                 365             


Leu Cys Ser Asn Ile His Ala Tyr Val Ser Ala Cys Gln Val Ala Gly 
    370                 375                 380                 


Gly His Val Glu Pro Trp Arg Asn Glu Thr Phe Cys Pro Met Glu Cys 
385                 390                 395                 400 


Pro Gln Asn Ser His Tyr Glu Leu Cys Ala Asp Thr Cys Ser Leu Gly 
                405                 410                 415     


Cys Ser Ala Leu Ser Ala Pro Leu Gln Cys Pro Asp Gly Cys Ala Glu 
            420                 425                 430         


Gly Cys Gln Cys Asp Ser Gly Phe Leu Tyr Asn Gly Gln Ala Cys Val 
        435                 440                 445             


Pro Ile Gln Gln Cys Gly Cys Tyr His Asn Gly Ala Tyr Tyr Glu Pro 
    450                 455                 460                 


Glu Gln Thr Val Leu Ile Asp Asn Cys Arg Gln Gln Cys Thr Cys His 
465                 470                 475                 480 


Ala Gly Lys Val Val Val Cys Gln Glu His Ser Cys Lys Pro Gly Gln 
                485                 490                 495     


Val Cys Gln Pro Ser Gly Gly Ile Leu Ser Cys Val Thr Lys Asp Pro 
            500                 505                 510         


Cys His Gly Val Thr Cys Arg Pro Gln Glu Thr Cys Lys Glu Gln Gly 
        515                 520                 525             


Gly Gln Gly Val Cys Leu Pro Asn Tyr Glu Ala Thr Cys Trp Leu Trp 
    530                 535                 540                 


Gly Asp Pro His Tyr His Ser Phe Asp Gly Arg Lys Phe Asp Phe Gln 
545                 550                 555                 560 


Gly Thr Cys Asn Tyr Val Leu Ala Thr Thr Gly Cys Pro Gly Val Ser 
                565                 570                 575     


Thr Gln Gly Leu Thr Pro Phe Thr Val Thr Thr Lys Asn Gln Asn Arg 
            580                 585                 590         


Gly Asn Pro Ala Val Ser Tyr Val Arg Val Val Thr Val Ala Ala Leu 
        595                 600                 605             


Gly Thr Asn Ile Ser Ile His Lys Asp Glu Ile Gly Lys Val Arg Val 
    610                 615                 620                 


Asn Gly Val Leu Thr Ala Leu Pro Val Ser Val Ala Asp Gly Arg Ile 
625                 630                 635                 640 


Ser Val Thr Gln Gly Ala Ser Lys Ala Leu Leu Val Ala Asp Phe Gly 
                645                 650                 655     


Leu Gln Val Ser Tyr Asp Trp Asn Trp Arg Val Asp Val Thr Leu Pro 
            660                 665                 670         


Ser Ser Tyr His Gly Ala Val Cys Gly Leu Cys Gly Asn Met Asp Arg 
        675                 680                 685             


Asn Pro Asn Asn Asp Gln Val Phe Pro Asn Gly Thr Leu Ala Pro Ser 
    690                 695                 700                 


Ile Pro Ile Trp Gly Gly Ser Trp Arg Ala Pro Gly Trp Asp Pro Leu 
705                 710                 715                 720 


Cys Trp Asp Glu Cys Arg Gly Ser Cys Pro Thr Cys Pro Glu Asp Arg 
                725                 730                 735     


Leu Glu Gln Tyr Glu Gly Pro Gly Phe Cys Gly Pro Leu Ala Pro Gly 
            740                 745                 750         


Thr Gly Gly Pro Phe Thr Thr Cys His Ala His Val Pro Pro Glu Ser 
        755                 760                 765             


Phe Phe Lys Gly Cys Val Leu Asp Val Cys Met Gly Gly Gly Asp Arg 
    770                 775                 780                 


Asp Ile Leu Cys Lys Ala Leu Ala Ser Tyr Val Ala Ala Cys Gln Ala 
785                 790                 795                 800 


Ala Gly Val Val Ile Glu Asp Trp Arg Ala Gln Val Gly Cys Glu Ile 
                805                 810                 815     


Thr Cys Pro Glu Asn Ser His Tyr Glu Val Cys Gly Pro Pro Cys Pro 
            820                 825                 830         


Ala Ser Cys Pro Ser Pro Ala Pro Leu Thr Thr Pro Ala Val Cys Glu 
        835                 840                 845             


Gly Pro Cys Val Glu Gly Cys Gln Cys Asp Ala Gly Phe Val Leu Ser 
    850                 855                 860                 


Ala Asp Arg Cys Val Pro Leu Asn Asn Gly Cys Gly Cys Trp Ala Asn 
865                 870                 875                 880 


Gly Thr Tyr His Glu Ala Gly Ser Glu Phe Trp Ala Asp Gly Thr Cys 
                885                 890                 895     


Ser Gln Trp Cys Arg Cys Gly Pro Gly Gly Gly Ser Leu Val Cys Thr 
            900                 905                 910         


Pro Ala Ser Cys Gly Leu Gly Glu Val Cys Gly Leu Leu Pro Ser Gly 
        915                 920                 925             


Gln His Gly Cys Gln Pro Val Ser Thr Ala Glu Cys Gln Ala Trp Gly 
    930                 935                 940                 


Asp Pro His Tyr Val Thr Leu Asp Gly His Arg Phe Asp Phe Gln Gly 
945                 950                 955                 960 


Thr Cys Glu Tyr Leu Leu Ser Ala Pro Cys His Gly Pro Pro Leu Gly 
                965                 970                 975     


Ala Glu Asn Phe Thr Val Thr Val Ala Asn Glu His Arg Gly Ser Gln 
            980                 985                 990         


Ala Val Ser Tyr Thr Arg Ser Val  Thr Leu Gln Ile Tyr  Asn His Ser 
        995                 1000                 1005             


Leu Thr  Leu Ser Ala Arg Trp  Pro Arg Lys Leu Gln  Val Asp Gly 
    1010                 1015                 1020             


Val Phe  Val Thr Leu Pro Phe  Gln Leu Asp Ser Leu  Leu His Ala 
    1025                 1030                 1035             


His Leu  Ser Gly Ala Asp Val  Val Val Thr Thr Thr  Ser Gly Leu 
    1040                 1045                 1050             


Ser Leu  Ala Phe Asp Gly Asp  Ser Phe Val Arg Leu  Arg Val Pro 
    1055                 1060                 1065             


Ala Ala  Tyr Ala Gly Ser Leu  Cys Gly Leu Cys Gly  Asn Tyr Asn 
    1070                 1075                 1080             


Gln Asp  Pro Ala Asp Asp Leu  Lys Ala Val Gly Gly  Lys Pro Ala 
    1085                 1090                 1095             


Gly Trp  Gln Val Gly Gly Ala  Gln Gly Cys Gly Glu  Cys Val Ser 
    1100                 1105                 1110             


Lys Pro  Cys Pro Ser Pro Cys  Thr Pro Glu Gln Gln  Glu Ser Phe 
    1115                 1120                 1125             


Gly Gly  Pro Asp Ala Cys Gly  Val Ile Ser Ala Thr  Asp Gly Pro 
    1130                 1135                 1140             


Leu Ala  Pro Cys His Gly Leu  Val Pro Pro Ala Gln  Tyr Phe Gln 
    1145                 1150                 1155             


Gly Cys  Leu Leu Asp Ala Cys  Gln Val Gln Gly His  Pro Gly Gly 
    1160                 1165                 1170             


Leu Cys  Pro Ala Val Ala Thr  Tyr Val Ala Ala Cys  Gln Ala Ala 
    1175                 1180                 1185             


Gly Ala  Gln Leu Arg Glu Trp  Arg Arg Pro Asp Phe  Cys Pro Phe 
    1190                 1195                 1200             


Gln Cys  Pro Ala His Ser His  Tyr Glu Leu Cys Gly  Asp Ser Cys 
    1205                 1210                 1215             


Pro Gly  Ser Cys Pro Ser Leu  Ser Ala Pro Glu Gly  Cys Glu Ser 
    1220                 1225                 1230             


Ala Cys  Arg Glu Gly Cys Val  Cys Asp Ala Gly Phe  Val Leu Ser 
    1235                 1240                 1245             


Gly Asp  Thr Cys Val Pro Val  Gly Gln Cys Gly Cys  Leu His Asp 
    1250                 1255                 1260             


Asp Arg  Tyr Tyr Pro Leu Gly  Gln Thr Phe Tyr Pro  Gly Pro Gly 
    1265                 1270                 1275             


Cys Asp  Ser Leu Cys Arg Cys  Arg Glu Gly Gly Glu  Val Ser Cys 
    1280                 1285                 1290             


Glu Pro  Ser Ser Cys Gly Pro  His Glu Thr Cys Arg  Pro Ser Gly 
    1295                 1300                 1305             


Gly Ser  Leu Gly Cys Val Ala  Val Gly Ser Thr Thr  Cys Gln Ala 
    1310                 1315                 1320             


Ser Gly  Asp Pro His Tyr Thr  Thr Phe Asp Gly His  Arg Phe Asp 
    1325                 1330                 1335             


Phe Met  Gly Thr Cys Val Tyr  Val Leu Ala Gln Thr  Cys Gly Thr 
    1340                 1345                 1350             


Arg Pro  Gly Leu His Arg Phe  Ala Val Leu Gln Glu  Asn Val Ala 
    1355                 1360                 1365             


Trp Gly  Asn Gly Arg Val Ser  Val Thr Arg Val Ile  Thr Val Gln 
    1370                 1375                 1380             


Val Ala  Asn Phe Thr Leu Arg  Leu Glu Gln Arg Gln  Trp Lys Val 
    1385                 1390                 1395             


Thr Val  Asn Gly Val Asp Met  Lys Leu Pro Val Val  Leu Ala Asn 
    1400                 1405                 1410             


Gly Gln  Ile Arg Ala Ser Gln  His Gly Ser Asp Val  Val Ile Glu 
    1415                 1420                 1425             


Thr Asp  Phe Gly Leu Arg Val  Ala Tyr Asp Leu Val  Tyr Tyr Val 
    1430                 1435                 1440             


Arg Val  Thr Val Pro Gly Asn  Tyr Tyr Gln Leu Met  Cys Gly Leu 
    1445                 1450                 1455             


Cys Gly  Asn Tyr Asn Gly Asp  Pro Lys Asp Asp Phe  Gln Lys Pro 
    1460                 1465                 1470             


Asn Gly  Ser Gln Ala Gly Asn  Ala Asn Glu Phe Gly  Asn Ser Trp 
    1475                 1480                 1485             


Glu Glu  Val Val Pro Asp Ser  Pro Cys Leu Pro Pro  Pro Thr Cys 
    1490                 1495                 1500             


Pro Pro  Gly Ser Ala Gly Cys  Ile Pro Ser Asp Lys  Cys Pro Pro 
    1505                 1510                 1515             


Glu Leu  Glu Lys Lys Tyr Gln  Lys Glu Glu Phe Cys  Gly Leu Leu 
    1520                 1525                 1530             


Ser Ser  Pro Thr Gly Pro Leu  Ser Ser Cys His Lys  Leu Val Asp 
    1535                 1540                 1545             


Pro Gln  Gly Pro Leu Lys Asp  Cys Ile Phe Asp Leu  Cys Leu Gly 
    1550                 1555                 1560             


Gly Gly  Asn Leu Ser Ile Leu  Cys Ser Asn Ile His  Ala Tyr Val 
    1565                 1570                 1575             


Ser Ala  Cys Gln Ala Ala Gly  Gly His Val Glu Pro  Trp Arg Asn 
    1580                 1585                 1590             


Glu Thr  Phe Cys Pro Met Glu  Cys Pro Gln Asn Ser  His Tyr Glu 
    1595                 1600                 1605             


Leu Cys  Ala Asp Thr Cys Ser  Leu Gly Cys Ser Ala  Leu Ser Ala 
    1610                 1615                 1620             


Pro Leu  Gln Cys Pro Asp Gly  Cys Ala Glu Gly Cys  Gln Cys Asp 
    1625                 1630                 1635             


Ser Gly  Phe Leu Tyr Asn Gly  Gln Ala Cys Val Pro  Ile Gln Gln 
    1640                 1645                 1650             


Cys Gly  Cys Tyr His Asn Gly  Val Tyr Tyr Glu Pro  Glu Gln Thr 
    1655                 1660                 1665             


Val Leu  Ile Asp Asn Cys Arg  Gln Gln Cys Thr Cys  His Val Gly 
    1670                 1675                 1680             


Lys Val  Val Val Cys Gln Glu  His Ser Cys Lys Pro  Gly Gln Val 
    1685                 1690                 1695             


Cys Gln  Pro Ser Gly Gly Ile  Leu Ser Cys Val Thr  Lys Asp Pro 
    1700                 1705                 1710             


Cys His  Gly Val Thr Cys Arg  Pro Gln Glu Thr Cys  Lys Glu Gln 
    1715                 1720                 1725             


Gly Gly  Gln Gly Val Cys Leu  Pro Asn Tyr Glu Ala  Thr Cys Trp 
    1730                 1735                 1740             


Leu Trp  Gly Asp Pro His Tyr  His Ser Phe Asp Gly  Arg Lys Phe 
    1745                 1750                 1755             


Asp Phe  Gln Gly Thr Cys Asn  Tyr Val Leu Ala Thr  Thr Gly Cys 
    1760                 1765                 1770             


Pro Gly  Val Ser Thr Gln Gly  Leu Thr Pro Phe Thr  Val Thr Thr 
    1775                 1780                 1785             


Lys Asn  Gln Asn Arg Gly Asn  Pro Ala Val Ser Tyr  Val Arg Val 
    1790                 1795                 1800             


Val Thr  Val Ala Ala Leu Gly  Thr Asn Ile Ser Ile  His Lys Asp 
    1805                 1810                 1815             


Glu Ile  Gly Lys Val Arg Val  Asn Gly Val Leu Thr  Ala Leu Pro 
    1820                 1825                 1830             


Val Ser  Val Ala Asp Gly Arg  Ile Ser Val Ala Gln  Gly Ala Ser 
    1835                 1840                 1845             


Lys Ala  Leu Leu Val Ala Asp  Phe Gly Leu Gln Val  Ser Tyr Asp 
    1850                 1855                 1860             


Trp Asn  Trp Arg Val Asp Val  Thr Leu Pro Ser Ser  Tyr His Gly 
    1865                 1870                 1875             


Ala Val  Cys Gly Leu Cys Gly  Asn Met Asp Arg Asn  Pro Asn Asn 
    1880                 1885                 1890             


Asp Gln  Val Phe Pro Asn Gly  Thr Leu Ala Pro Ser  Ile Pro Ile 
    1895                 1900                 1905             


Trp Gly  Gly Ser Trp Arg Ala  Pro Gly Trp Asp Pro  Leu Cys Trp 
    1910                 1915                 1920             


Asp Glu  Cys Arg Gly Ser Cys  Pro Thr Cys Pro Glu  Asp Arg Leu 
    1925                 1930                 1935             


Glu Gln  Tyr Glu Gly Pro Gly  Phe Cys Gly Pro Leu  Ser Ser Gly 
    1940                 1945                 1950             


Thr Gly  Gly Pro Phe Thr Thr  Cys His Ala His Val  Pro Pro Glu 
    1955                 1960                 1965             


Ser Phe  Phe Lys Gly Cys Val  Leu Asp Val Cys Met  Gly Gly Gly 
    1970                 1975                 1980             


Asp Arg  Asp Ile Leu Cys Lys  Ala Leu Ala Ser Tyr  Val Ala Ala 
    1985                 1990                 1995             


Cys Gln  Ala Ala Gly Val Val  Ile Glu Asp Trp Arg  Ala Gln Val 
    2000                 2005                 2010             


Gly Cys  Glu Ile Thr Cys Pro  Glu Asn Ser His Tyr  Glu Val Cys 
    2015                 2020                 2025             


Gly Pro  Pro Cys Pro Ala Ser  Cys Pro Ser Pro Ala  Pro Leu Thr 
    2030                 2035                 2040             


Thr Pro  Ala Val Cys Glu Gly  Pro Cys Val Glu Gly  Cys Gln Cys 
    2045                 2050                 2055             


Asp Ala  Gly Phe Val Leu Ser  Ala Asp Arg Cys Val  Pro Leu Asn 
    2060                 2065                 2070             


Asn Gly  Cys Gly Cys Trp Ala  Asn Gly Thr Tyr His  Glu Ala Gly 
    2075                 2080                 2085             


Ser Glu  Phe Trp Ala Asp Gly  Thr Cys Ser Gln Trp  Cys Arg Cys 
    2090                 2095                 2100             


Gly Pro  Gly Gly Gly Ser Leu  Val Cys Thr Pro Ala  Ser Cys Gly 
    2105                 2110                 2115             


Leu Gly  Glu Val Cys Gly Leu  Leu Pro Ser Gly Gln  His Gly Cys 
    2120                 2125                 2130             


Gln Pro  Val Ser Thr Ala Glu  Cys Gln Ala Trp Gly  Asp Pro His 
    2135                 2140                 2145             


Tyr Val  Thr Leu Asp Gly His  Arg Phe Asp Phe Gln  Gly Thr Cys 
    2150                 2155                 2160             


Glu Tyr  Leu Leu Ser Ala Pro  Cys His Gly Pro Pro  Leu Gly Ala 
    2165                 2170                 2175             


Glu Asn  Phe Thr Val Thr Val  Ala Asn Glu His Arg  Gly Ser Gln 
    2180                 2185                 2190             


Ala Val  Ser Tyr Thr Arg Ser  Val Thr Leu Gln Ile  Tyr Asn His 
    2195                 2200                 2205             


Ser Leu  Thr Leu Ser Ala Arg  Trp Pro Arg Lys Leu  Gln Val Asp 
    2210                 2215                 2220             


Gly Val  Phe Val Ala Leu Pro  Phe Gln Leu Asp Ser  Leu Leu His 
    2225                 2230                 2235             


Ala His  Leu Ser Gly Ala Asp  Val Val Val Thr Thr  Thr Ser Gly 
    2240                 2245                 2250             


Leu Ser  Leu Ala Phe Asp Gly  Asp Ser Phe Val Arg  Leu Arg Val 
    2255                 2260                 2265             


Pro Ala  Ala Tyr Ala Ala Ser  Leu Cys Gly Leu Cys  Gly Asn Tyr 
    2270                 2275                 2280             


Asn Gln  Asp Pro Ala Asp Asp  Leu Lys Ala Val Gly  Gly Lys Pro 
    2285                 2290                 2295             


Ala Gly  Trp Gln Val Gly Gly  Ala Gln Gly Cys Gly  Glu Cys Val 
    2300                 2305                 2310             


Ser Lys  Pro Cys Pro Ser Pro  Cys Thr Pro Glu Gln  Gln Glu Ser 
    2315                 2320                 2325             


Phe Gly  Gly Pro Asp Ala Cys  Gly Val Ile Ser Ala  Thr Asp Gly 
    2330                 2335                 2340             


Pro Leu  Ala Pro Cys His Gly  Leu Val Pro Pro Ala  Gln Tyr Phe 
    2345                 2350                 2355             


Gln Gly  Cys Leu Leu Asp Ala  Cys Gln Val Gln Gly  His Pro Gly 
    2360                 2365                 2370             


Gly Leu  Cys Pro Ala Val Ala  Thr Tyr Val Ala Ala  Cys Gln Ala 
    2375                 2380                 2385             


Ala Gly  Ala Gln Leu Gly Glu  Trp Arg Arg Pro Asp  Phe Cys Pro 
    2390                 2395                 2400             


Leu Gln  Cys Pro Ala His Ser  His Tyr Glu Leu Cys  Gly Asp Ser 
    2405                 2410                 2415             


Cys Pro  Val Ser Cys Pro Ser  Leu Ser Ala Pro Glu  Gly Cys Glu 
    2420                 2425                 2430             


Ser Ala  Cys Arg Glu Gly Cys  Val Cys Asp Ala Gly  Phe Val Leu 
    2435                 2440                 2445             


Ser Gly  Asp Thr Cys Val Pro  Val Gly Gln Cys Gly  Cys Leu His 
    2450                 2455                 2460             


Asp Gly  Arg Tyr Tyr Pro Leu  Gly Glu Val Phe Tyr  Pro Gly Pro 
    2465                 2470                 2475             


Glu Cys  Glu Arg Arg Cys Glu  Cys Gly Pro Gly Gly  His Val Thr 
    2480                 2485                 2490             


Cys Gln  Glu Gly Ala Ala Cys  Gly Pro His Glu Glu  Cys Arg Leu 
    2495                 2500                 2505             


Glu Asp  Gly Val Gln Ala Cys  His Ala Thr Gly Cys  Gly Arg Cys 
    2510                 2515                 2520             


Leu Ala  Asn Gly Gly Ile His  Tyr Ile Thr Leu Asp  Gly Arg Val 
    2525                 2530                 2535             


Tyr Asp  Leu His Gly Ser Cys  Ser Tyr Val Leu Ala  Gln Val Cys 
    2540                 2545                 2550             


His Pro  Lys Pro Gly Asp Glu  Asp Phe Ser Ile Val  Leu Glu Lys 
    2555                 2560                 2565             


Asn Ala  Ala Gly Asp Leu Gln  Arg Leu Leu Val Thr  Val Ala Gly 
    2570                 2575                 2580             


Gln Val  Val Ser Leu Ala Gln  Gly Gln Gln Val Thr  Val Asp Gly 
    2585                 2590                 2595             


Glu Ala  Val Ala Leu Pro Val  Ala Val Gly Arg Val  Arg Val Thr 
    2600                 2605                 2610             


Ala Glu  Gly Arg Asn Met Val  Leu Gln Thr Thr Lys  Gly Leu Arg 
    2615                 2620                 2625             


Leu Leu  Phe Asp Gly Asp Ala  His Leu Leu Met Ser  Ile Pro Ser 
    2630                 2635                 2640             


Pro Phe  Arg Gly Arg Leu Cys  Gly Leu Cys Gly Asn  Phe Asn Gly 
    2645                 2650                 2655             


Asn Trp  Ser Asp Asp Phe Val  Leu Pro Asn Gly Ser  Ala Ala Ser 
    2660                 2665                 2670             


Ser Val  Glu Thr Phe Gly Ala  Ala Trp Arg Ala Pro  Gly Ser Ser 
    2675                 2680                 2685             


Lys Gly  Cys Gly Glu Gly Cys  Gly Pro Gln Gly Cys  Pro Val Cys 
    2690                 2695                 2700             


Leu Ala  Glu Glu Thr Ala Pro  Tyr Glu Ser Asn Glu  Ala Cys Gly 
    2705                 2710                 2715             


Gln Leu  Arg Asn Pro Gln Gly  Pro Phe Ala Thr Cys  Gln Ala Val 
    2720                 2725                 2730             


Leu Ser  Pro Ser Glu Tyr Phe  Arg Gln Cys Val Tyr  Asp Leu Cys 
    2735                 2740                 2745             


Ala Gln  Lys Gly Asp Lys Ala  Phe Leu Cys Arg Ser  Leu Ala Ala 
    2750                 2755                 2760             


Tyr Thr  Ala Ala Cys Gln Ala  Ala Gly Val Ala Val  Lys Pro Trp 
    2765                 2770                 2775             


Arg Thr  Asp Ser Phe Cys Pro  Leu His Cys Pro Ala  His Ser His 
    2780                 2785                 2790             


Tyr Ser  Ile Cys Thr Arg Thr  Cys Gln Gly Ser Cys  Ala Ala Leu 
    2795                 2800                 2805             


Ser Gly  Leu Thr Gly Cys Thr  Thr Arg Cys Phe Glu  Gly Cys Glu 
    2810                 2815                 2820             


Cys Asp  Asp Arg Phe Leu Leu  Ser Gln Gly Val Cys  Ile Pro Val 
    2825                 2830                 2835             


Gln Asp  Cys Gly Cys Thr His  Asn Gly Arg Tyr Leu  Pro Val Asn 
    2840                 2845                 2850             


Ser Ser  Leu Leu Thr Ser Asp  Cys Ser Glu Arg Cys  Ser Cys Ser 
    2855                 2860                 2865             


Ser Ser  Ser Gly Leu Thr Cys  Gln Ala Ala Gly Cys  Pro Pro Gly 
    2870                 2875                 2880             


Arg Val  Cys Glu Val Lys Ala  Glu Ala Arg Asn Cys  Trp Ala Thr 
    2885                 2890                 2895             


Arg Gly  Leu Cys Val Leu Ser  Val Gly Ala Asn Leu  Thr Thr Phe 
    2900                 2905                 2910             


Asp Gly  Ala Arg Gly Ala Thr  Thr Ser Pro Gly Val  Tyr Glu Leu 
    2915                 2920                 2925             


Ser Ser  Arg Cys Pro Gly Leu  Gln Asn Thr Ile Pro  Trp Tyr Arg 
    2930                 2935                 2940             


Val Val  Ala Glu Val Gln Ile  Cys His Gly Lys Thr  Glu Ala Val 
    2945                 2950                 2955             


Gly Gln  Val His Ile Phe Phe  Gln Asp Gly Met Val  Thr Leu Thr 
    2960                 2965                 2970             


Pro Asn  Lys Gly Val Trp Val  Asn Gly Leu Arg Val  Asp Leu Pro 
    2975                 2980                 2985             


Ala Glu  Lys Leu Ala Ser Val  Ser Val Ser Arg Thr  Pro Asp Gly 
    2990                 2995                 3000             


Ser Leu  Leu Val Arg Gln Lys  Ala Gly Val Gln Val  Trp Leu Gly 
    3005                 3010                 3015             


Ala Asn  Gly Lys Val Ala Val  Ile Val Ser Asn Asp  His Ala Gly 
    3020                 3025                 3030             


Lys Leu  Cys Gly Ala Cys Gly  Asn Phe Asp Gly Asp  Gln Thr Asn 
    3035                 3040                 3045             


Asp Trp  His Asp Ser Gln Glu  Lys Pro Ala Met Glu  Lys Trp Arg 
    3050                 3055                 3060             


Ala Gln  Asp Phe Ser Pro Cys  Tyr Gly 
    3065                 3070         


<210>  5191
<211>  250
<212>  PRT
<213>  Homo Sapiens

<400>  5191

Met Gly Lys Trp Pro Pro Trp Val Ser Val Phe Gln Glu Glu Thr Ile 
1               5                   10                  15      


Thr Leu His Cys Glu Val Leu His Leu Pro Gly Ser Ser Ser Thr Gln 
            20                  25                  30          


Trp Phe Leu Asn Gly Thr Ala Thr Gln Thr Ser Thr Pro Ser Tyr Arg 
        35                  40                  45              


Ile Thr Ser Ala Ser Val Asn Asp Ser Gly Glu Tyr Arg Cys Gln Arg 
    50                  55                  60                  


Gly Leu Ser Gly Arg Ser Asp Pro Ile Gln Leu Glu Ile His Arg Gly 
65                  70                  75                  80  


Trp Leu Leu Leu Gln Val Ser Ser Arg Val Phe Met Glu Gly Glu Pro 
                85                  90                  95      


Leu Ala Leu Arg Cys His Ala Trp Lys Asp Lys Leu Val Tyr Asn Val 
            100                 105                 110         


Leu Tyr Tyr Arg Asn Gly Lys Ala Phe Lys Phe Phe His Trp Asn Ser 
        115                 120                 125             


Asn Leu Thr Ile Leu Lys Thr Asn Ile Ser His Asn Gly Thr Tyr His 
    130                 135                 140                 


Cys Ser Gly Met Gly Lys His Arg Tyr Thr Ser Ala Gly Ile Ser Gln 
145                 150                 155                 160 


Tyr Thr Val Lys Gly Leu Gln Leu Pro Thr Pro Val Trp Phe His Val 
                165                 170                 175     


Leu Phe Tyr Leu Ala Val Gly Ile Met Phe Leu Val Asn Thr Val Leu 
            180                 185                 190         


Trp Val Thr Ile Arg Lys Glu Leu Lys Arg Lys Lys Lys Trp Asn Leu 
        195                 200                 205             


Glu Ile Ser Leu Asp Ser Gly His Glu Lys Lys Val Ile Ser Ser Leu 
    210                 215                 220                 


Gln Glu Asp Arg His Leu Glu Glu Glu Leu Lys Cys Gln Glu Gln Lys 
225                 230                 235                 240 


Glu Glu Gln Leu Gln Glu Gly Val His Arg 
                245                 250 


<210>  5192
<211>  188
<212>  PRT
<213>  Homo Sapiens

<400>  5192

Met Trp Phe Leu Thr Thr Leu Leu Leu Trp Gly Trp Leu Leu Leu Gln 
1               5                   10                  15      


Val Ser Ser Arg Val Phe Met Glu Gly Glu Pro Leu Ala Leu Arg Cys 
            20                  25                  30          


His Ala Trp Lys Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr Arg Asn 
        35                  40                  45              


Gly Lys Ala Phe Lys Phe Phe His Trp Asn Ser Asn Leu Thr Ile Leu 
    50                  55                  60                  


Lys Thr Asn Ile Ser His Asn Gly Thr Tyr His Cys Ser Gly Met Gly 
65                  70                  75                  80  


Lys His Arg Tyr Thr Ser Ala Gly Ile Ser Gln Tyr Thr Val Lys Gly 
                85                  90                  95      


Leu Gln Leu Pro Thr Pro Val Trp Phe His Val Leu Phe Tyr Leu Ala 
            100                 105                 110         


Val Gly Ile Met Phe Leu Val Asn Thr Val Leu Trp Val Thr Ile Arg 
        115                 120                 125             


Lys Glu Leu Lys Arg Lys Lys Lys Trp Asn Leu Glu Ile Ser Leu Asp 
    130                 135                 140                 


Ser Gly His Glu Lys Lys Val Ile Ser Ser Leu Gln Glu Asp Arg His 
145                 150                 155                 160 


Leu Glu Glu Glu Leu Lys Cys Gln Glu Gln Lys Glu Glu Gln Leu Gln 
                165                 170                 175     


Glu Gly Val His Arg Lys Glu Pro Gln Gly Ala Thr 
            180                 185             


<210>  5193
<211>  224
<212>  PRT
<213>  Homo Sapiens

<400>  5193

Met Trp Phe Leu Thr Thr Leu Leu Leu Trp Val Pro Val Asp Gly Gln 
1               5                   10                  15      


Val Asp Thr Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp Val Ser 
            20                  25                  30          


Val Phe Gln Glu Glu Thr Ile Thr Leu His Cys Glu Val Leu His Leu 
        35                  40                  45              


Pro Gly Ser Ser Ser Thr Gln Trp Phe Leu Asn Gly Thr Ala Thr Gln 
    50                  55                  60                  


Thr Ser Thr Pro Ser Tyr Arg Ile Thr Ser Ala Ser Val Asn Asp Ser 
65                  70                  75                  80  


Gly Glu Tyr Arg Cys Gln Arg Gly Leu Ser Gly Arg Ser Asp Pro Ile 
                85                  90                  95      


Gln Leu Glu Ile His Arg Gly Trp Leu Leu Leu Gln Val Ser Ser Arg 
            100                 105                 110         


Val Phe Met Glu Gly Glu Pro Leu Ala Leu Arg Cys His Ala Trp Lys 
        115                 120                 125             


Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr Arg Asn Gly Lys Ala Phe 
    130                 135                 140                 


Lys Phe Phe His Trp Asn Ser Asn Leu Thr Ile Leu Lys Thr Asn Ile 
145                 150                 155                 160 


Ser His Asn Gly Thr Tyr His Cys Ser Gly Met Gly Lys His Arg Tyr 
                165                 170                 175     


Thr Ser Ala Gly Ile Ser Gln Tyr Thr Val Lys Glu Leu Phe Pro Ala 
            180                 185                 190         


Pro Val Leu Asn Ala Ser Val Thr Ser Pro Leu Leu Glu Gly Asn Leu 
        195                 200                 205             


Val Thr Leu Ser Cys Glu Thr Lys Leu Leu Leu Gln Arg Pro Gly Leu 
    210                 215                 220                 


<210>  5194
<211>  224
<212>  PRT
<213>  Homo Sapiens

<400>  5194

Met Trp Phe Leu Thr Thr Leu Leu Leu Trp Val Pro Val Asp Gly Gln 
1               5                   10                  15      


Val Asp Thr Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp Val Ser 
            20                  25                  30          


Val Phe Gln Glu Glu Thr Ile Thr Leu His Cys Glu Val Leu His Leu 
        35                  40                  45              


Pro Gly Ser Ser Ser Thr Gln Trp Phe Leu Asn Gly Thr Ala Thr Gln 
    50                  55                  60                  


Thr Ser Thr Pro Ser Tyr Arg Ile Thr Ser Ala Ser Val Asn Asp Ser 
65                  70                  75                  80  


Gly Glu Tyr Arg Cys Gln Arg Gly Leu Ser Gly Arg Ser Asp Pro Ile 
                85                  90                  95      


Gln Leu Glu Ile His Arg Gly Trp Leu Leu Leu Gln Val Ser Ser Arg 
            100                 105                 110         


Val Phe Met Glu Gly Glu Pro Leu Ala Leu Arg Cys His Ala Trp Lys 
        115                 120                 125             


Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr Arg Asn Gly Lys Ala Phe 
    130                 135                 140                 


Lys Phe Phe His Trp Asn Ser Asn Leu Thr Ile Leu Lys Thr Asn Ile 
145                 150                 155                 160 


Ser His Asn Gly Thr Tyr His Cys Ser Gly Met Gly Lys His Arg Tyr 
                165                 170                 175     


Thr Ser Ala Gly Ile Ser Gln Tyr Thr Val Lys Glu Leu Phe Pro Ala 
            180                 185                 190         


Pro Val Leu Asn Ala Ser Val Thr Ser Pro Leu Leu Glu Gly Asn Leu 
        195                 200                 205             


Val Thr Leu Ser Cys Glu Thr Lys Leu Leu Leu Gln Arg Pro Gly Leu 
    210                 215                 220                 


<210>  5195
<211>  280
<212>  PRT
<213>  Homo Sapiens

<400>  5195

Met Trp Phe Leu Thr Thr Leu Leu Leu Trp Val Pro Val Asp Gly Gln 
1               5                   10                  15      


Val Asp Thr Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp Val Ser 
            20                  25                  30          


Val Phe Gln Glu Glu Thr Ile Thr Leu His Cys Glu Val Leu His Leu 
        35                  40                  45              


Pro Gly Ser Ser Ser Thr Gln Trp Phe Leu Asn Gly Thr Ala Thr Gln 
    50                  55                  60                  


Thr Ser Thr Pro Ser Tyr Arg Ile Thr Ser Ala Ser Val Asn Asp Ser 
65                  70                  75                  80  


Gly Glu Tyr Arg Cys Gln Arg Gly Leu Ser Gly Arg Ser Asp Pro Ile 
                85                  90                  95      


Gln Leu Glu Ile His Arg Gly Trp Leu Leu Leu Gln Val Ser Ser Arg 
            100                 105                 110         


Val Phe Met Glu Gly Glu Pro Leu Ala Leu Arg Cys His Ala Trp Lys 
        115                 120                 125             


Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr Arg Asn Gly Lys Ala Phe 
    130                 135                 140                 


Lys Phe Phe His Trp Asn Ser Asn Leu Thr Ile Leu Lys Thr Asn Ile 
145                 150                 155                 160 


Ser His Asn Gly Thr Tyr His Cys Ser Gly Met Gly Lys His Arg Tyr 
                165                 170                 175     


Thr Ser Ala Gly Ile Ser Gln Tyr Thr Val Lys Gly Leu Gln Leu Pro 
            180                 185                 190         


Thr Pro Val Trp Phe His Val Leu Phe Tyr Leu Ala Val Gly Ile Met 
        195                 200                 205             


Phe Leu Val Asn Thr Val Leu Trp Val Thr Ile Arg Lys Glu Leu Lys 
    210                 215                 220                 


Arg Lys Lys Lys Trp Asn Leu Glu Ile Ser Leu Asp Ser Gly His Glu 
225                 230                 235                 240 


Lys Lys Val Ile Ser Ser Leu Gln Glu Asp Arg His Leu Glu Glu Glu 
                245                 250                 255     


Leu Lys Cys Gln Glu Gln Lys Glu Glu Gln Leu Gln Glu Gly Val His 
            260                 265                 270         


Arg Lys Glu Pro Gln Gly Ala Thr 
        275                 280 


<210>  5196
<211>  225
<212>  PRT
<213>  Homo Sapiens

<400>  5196

Met Trp Phe Leu Thr Thr Leu Leu Leu Trp Val Pro Val Asp Gly Gln 
1               5                   10                  15      


Val Val Asp Thr Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp Val 
            20                  25                  30          


Ser Val Phe Gln Glu Glu Thr Ile Thr Leu His Cys Glu Val Leu His 
        35                  40                  45              


Leu Pro Gly Ser Ser Ser Thr Gln Trp Phe Leu Asn Gly Thr Ala Thr 
    50                  55                  60                  


Gln Thr Ser Thr Pro Ser Tyr Arg Ile Thr Ser Ala Ser Val Asn Asp 
65                  70                  75                  80  


Ser Gly Glu Tyr Arg Cys Gln Arg Gly Leu Ser Gly Arg Ser Asp Pro 
                85                  90                  95      


Ile Gln Leu Glu Ile His Arg Gly Trp Leu Leu Leu Gln Val Ser Ser 
            100                 105                 110         


Arg Val Phe Met Glu Gly Glu Pro Leu Ala Leu Arg Cys His Ala Trp 
        115                 120                 125             


Lys Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr Arg Asn Gly Lys Ala 
    130                 135                 140                 


Phe Lys Phe Phe His Trp Asn Ser Asn Leu Thr Ile Leu Lys Thr Asn 
145                 150                 155                 160 


Ile Ser His Asn Gly Thr Tyr His Cys Ser Gly Met Gly Lys His Arg 
                165                 170                 175     


Tyr Thr Ser Ala Gly Ile Ser Gln Tyr Thr Val Lys Glu Leu Phe Pro 
            180                 185                 190         


Ala Pro Val Leu Asn Ala Ser Val Thr Ser Pro Leu Leu Glu Gly Asn 
        195                 200                 205             


Leu Val Thr Leu Ser Cys Glu Thr Lys Leu Leu Leu Gln Arg Pro Gly 
    210                 215                 220                 


Leu 
225 


<210>  5197
<211>  359
<212>  PRT
<213>  Homo Sapiens

<400>  5197

Met Ala Glu Gly Thr Leu Trp Gln Ile Leu Cys Val Ser Ser Asp Ala 
1               5                   10                  15      


Gln Pro Gln Thr Phe Glu Gly Val Lys Gly Ala Asp Pro Pro Thr Leu 
            20                  25                  30          


Pro Pro Gly Ser Phe Leu Pro Gly Pro Val Leu Trp Trp Gly Ser Leu 
        35                  40                  45              


Ala Arg Leu Gln Thr Glu Lys Ser Asp Glu Val Ser Arg Lys Gly Asn 
    50                  55                  60                  


Trp Trp Val Thr Glu Met Gly Gly Gly Ala Gly Glu Arg Leu Phe Thr 
65                  70                  75                  80  


Ser Ser Cys Leu Val Gly Leu Val Pro Leu Gly Leu Arg Ile Ser Leu 
                85                  90                  95      


Val Thr Cys Pro Leu Gln Cys Gly Ile Met Trp Gln Leu Leu Leu Pro 
            100                 105                 110         


Thr Ala Leu Leu Leu Leu Val Ser Ala Gly Met Arg Thr Glu Asp Leu 
        115                 120                 125             


Pro Lys Ala Val Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu 
    130                 135                 140                 


Lys Asp Ser Val Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp 
145                 150                 155                 160 


Asn Ser Thr Gln Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala 
                165                 170                 175     


Ser Ser Tyr Phe Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr 
            180                 185                 190         


Arg Cys Gln Thr Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu 
        195                 200                 205             


Val His Ile Gly Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys 
    210                 215                 220                 


Glu Glu Asp Pro Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala 
225                 230                 235                 240 


Leu His Lys Val Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe 
                245                 250                 255     


His His Asn Ser Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser 
            260                 265                 270         


Gly Ser Tyr Phe Cys Arg Gly Leu Phe Gly Ser Lys Asn Val Ser Ser 
        275                 280                 285             


Glu Thr Val Asn Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile 
    290                 295                 300                 


Ser Ser Phe Phe Pro Pro Gly Tyr Gln Val Ser Phe Cys Leu Val Met 
305                 310                 315                 320 


Val Leu Leu Phe Ala Val Asp Thr Gly Leu Tyr Phe Ser Val Lys Thr 
                325                 330                 335     


Asn Ile Arg Ser Ser Thr Arg Asp Trp Lys Asp His Lys Phe Lys Trp 
            340                 345                 350         


Arg Lys Asp Pro Gln Asp Lys 
        355                 


<210>  5198
<211>  290
<212>  PRT
<213>  Homo Sapiens

<400>  5198

Met Gly Gly Gly Ala Gly Glu Arg Leu Phe Thr Ser Ser Cys Leu Val 
1               5                   10                  15      


Gly Leu Val Pro Leu Gly Leu Arg Ile Ser Leu Val Thr Cys Pro Leu 
            20                  25                  30          


Gln Cys Gly Ile Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu 
        35                  40                  45              


Leu Val Ser Ala Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val 
    50                  55                  60                  


Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr 
65                  70                  75                  80  


Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp 
                85                  90                  95      


Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile 
            100                 105                 110         


Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn 
        115                 120                 125             


Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp 
    130                 135                 140                 


Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile 
145                 150                 155                 160 


His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr 
                165                 170                 175     


Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp 
            180                 185                 190         


Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys 
        195                 200                 205             


Arg Gly Leu Phe Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile 
    210                 215                 220                 


Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro 
225                 230                 235                 240 


Pro Gly Tyr Gln Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala 
                245                 250                 255     


Val Asp Thr Gly Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser 
            260                 265                 270         


Thr Arg Asp Trp Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln 
        275                 280                 285             


Asp Lys 
    290 


<210>  5199
<211>  105
<212>  PRT
<213>  Homo Sapiens

<400>  5199

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro Gln 
            20                  25                  30          


Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln Gly 
        35                  40                  45              


Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu Ser 
    50                  55                  60                  


Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr Val 
65                  70                  75                  80  


Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu Ser 
                85                  90                  95      


Asp Pro Val Gln Leu Glu Val His Ile 
            100                 105 


<210>  5200
<211>  254
<212>  PRT
<213>  Homo Sapiens

<400>  5200

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Phe 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
    210                 215                 220                 


Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp 
225                 230                 235                 240 


Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
                245                 250                 


<210>  5201
<211>  254
<212>  PRT
<213>  Homo Sapiens

<400>  5201

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Phe 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
    210                 215                 220                 


Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp 
225                 230                 235                 240 


Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
                245                 250                 


<210>  5202
<211>  254
<212>  PRT
<213>  Homo Sapiens

<400>  5202

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Phe 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
    210                 215                 220                 


Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp 
225                 230                 235                 240 


Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
                245                 250                 


<210>  5203
<211>  307
<212>  PRT
<213>  Homo Sapiens

<400>  5203

Gln Thr Glu Lys Ser Asp Glu Val Ser Arg Lys Gly Asn Trp Trp Val 
1               5                   10                  15      


Thr Glu Met Gly Gly Gly Ala Gly Glu Arg Leu Phe Thr Ser Ser Cys 
            20                  25                  30          


Leu Val Gly Leu Val Pro Leu Gly Leu Arg Ile Ser Leu Val Thr Cys 
        35                  40                  45              


Pro Leu Gln Cys Gly Ile Met Trp Gln Leu Leu Leu Pro Thr Ala Leu 
    50                  55                  60                  


Leu Leu Leu Val Ser Ala Gly Met Arg Thr Asp Leu Pro Lys Ala Val 
65                  70                  75                  80  


Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val 
                85                  90                  95      


Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln 
            100                 105                 110         


Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe 
        115                 120                 125             


Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr 
    130                 135                 140                 


Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly 
145                 150                 155                 160 


Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro 
                165                 170                 175     


Ile His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val 
            180                 185                 190         


Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser 
        195                 200                 205             


Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe 
    210                 215                 220                 


Cys Arg Gly Leu Phe Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn 
225                 230                 235                 240 


Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe 
                245                 250                 255     


Pro Pro Gly Tyr Gln Val Ser Phe Cys Leu Val Met Val Leu Leu Phe 
            260                 265                 270         


Ala Val Asp Thr Gly Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser 
        275                 280                 285             


Ser Thr Arg Asp Trp Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro 
    290                 295                 300                 


Gln Asp Lys 
305         


<210>  5204
<211>  211
<212>  PRT
<213>  Homo Sapiens

<400>  5204

Gly Val Pro Arg Pro Gln Pro Trp Ala Leu Gly Leu Leu Leu Phe Leu 
1               5                   10                  15      


Leu Pro Gly Ser Leu Gly Ala Glu Ser His Leu Ser Leu Leu Tyr His 
            20                  25                  30          


Leu Thr Ala Val Ser Ser Pro Ala Pro Gly Thr Pro Ala Phe Trp Val 
        35                  40                  45              


Ser Gly Trp Leu Gly Pro Gln Gln Tyr Leu Ser Tyr Asn Ser Leu Arg 
    50                  55                  60                  


Gly Glu Ala Glu Pro Cys Gly Ala Trp Val Trp Glu Asn Gln Val Ser 
65                  70                  75                  80  


Trp Tyr Trp Glu Lys Glu Thr Thr Asp Leu Arg Ile Lys Glu Lys Leu 
                85                  90                  95      


Phe Leu Glu Ala Phe Lys Ala Leu Gly Gly Lys Gly Pro Tyr Thr Leu 
            100                 105                 110         


Gln Gly Leu Leu Gly Cys Glu Leu Gly Pro Asp Asn Thr Ser Val Pro 
        115                 120                 125             


Thr Ala Lys Phe Ala Leu Asn Gly Glu Glu Phe Met Asn Phe Asp Leu 
    130                 135                 140                 


Lys Gln Gly Thr Trp Gly Gly Asp Trp Pro Glu Ala Leu Ala Ile Ser 
145                 150                 155                 160 


Gln Arg Trp Gln Gln Gln Asp Lys Ala Ala Asn Lys Glu Leu Thr Phe 
                165                 170                 175     


Leu Leu Phe Ser Cys Pro His Arg Leu Arg Glu His Leu Glu Arg Gly 
            180                 185                 190         


Arg Gly Asn Leu Glu Trp Lys Glu Pro Lys Ala Arg Gln Ile Phe Cys 
        195                 200                 205             


Ala Trp Ile 
    210     


<210>  5205
<211>  273
<212>  PRT
<213>  Homo Sapiens

<400>  5205

Met Gly Val Pro Arg Pro Gln Pro Trp Ala Leu Gly Leu Leu Leu Phe 
1               5                   10                  15      


Leu Leu Pro Gly Ser Leu Gly Ala Glu Ser His Leu Ser Leu Leu Tyr 
            20                  25                  30          


His Leu Thr Ala Val Ser Ser Pro Ala Pro Gly Thr Pro Ala Phe Trp 
        35                  40                  45              


Val Ser Gly Trp Leu Gly Pro Gln Gln Tyr Leu Ser Tyr Asn Ser Leu 
    50                  55                  60                  


Arg Gly Glu Ala Glu Pro Cys Gly Ala Trp Val Trp Glu Asn Gln Val 
65                  70                  75                  80  


Ser Trp Tyr Trp Glu Lys Glu Thr Thr Asp Leu Arg Ile Lys Glu Lys 
                85                  90                  95      


Leu Phe Leu Glu Ala Phe Lys Ala Leu Gly Gly Lys Glu Pro Pro Ser 
            100                 105                 110         


Met Arg Leu Lys Ala Arg Pro Ser Ser Pro Gly Phe Ser Val Leu Thr 
        115                 120                 125             


Cys Ser Ala Phe Ser Phe Tyr Pro Pro Glu Leu Gln Leu Arg Phe Leu 
    130                 135                 140                 


Arg Asn Gly Leu Ala Ala Gly Thr Gly Gln Gly Asp Phe Gly Pro Asn 
145                 150                 155                 160 


Ser Asp Gly Ser Phe His Ala Ser Ser Ser Leu Thr Val Lys Ser Gly 
                165                 170                 175     


Asp Glu His His Tyr Cys Cys Ile Val Gln His Ala Gly Leu Ala Gln 
            180                 185                 190         


Pro Leu Arg Val Glu Leu Glu Ser Pro Ala Lys Ser Ser Val Leu Val 
        195                 200                 205             


Val Gly Ile Val Ile Gly Val Leu Leu Leu Thr Ala Ala Ala Val Gly 
    210                 215                 220                 


Gly Ala Leu Leu Trp Arg Arg Met Arg Ser Gly Leu Pro Ala Pro Trp 
225                 230                 235                 240 


Ile Ser Leu Arg Gly Asp Asp Thr Gly Val Leu Leu Pro Thr Pro Gly 
                245                 250                 255     


Glu Ala Gln Asp Ala Asp Leu Lys Asp Val Asn Val Ile Pro Ala Thr 
            260                 265                 270         


Ala 
    


<210>  5206
<211>  141
<212>  PRT
<213>  Homo Sapiens

<400>  5206

Met Gly Val Pro Arg Pro Gln Pro Trp Ala Leu Gly Leu Leu Leu Phe 
1               5                   10                  15      


Leu Leu Pro Gly Ser Leu Gly Ala Glu Ser His Leu Ser Leu Leu Tyr 
            20                  25                  30          


His Leu Thr Ala Val Ser Ser Pro Ala Pro Gly Thr Pro Ala Phe Trp 
        35                  40                  45              


Val Ser Gly Trp Leu Gly Pro Gln Gln Tyr Leu Ser Tyr Asn Ser Leu 
    50                  55                  60                  


Arg Gly Glu Ala Glu Pro Cys Gly Ala Trp Val Trp Glu Asn Gln Val 
65                  70                  75                  80  


Ser Trp Tyr Trp Glu Lys Glu Thr Thr Asp Leu Arg Ile Lys Glu Lys 
                85                  90                  95      


Leu Phe Leu Glu Ala Phe Lys Ala Leu Gly Gly Lys Gly Pro Tyr Thr 
            100                 105                 110         


Leu Gln Gly Leu Leu Gly Cys Glu Leu Gly Pro Asp Asn Thr Ser Val 
        115                 120                 125             


Pro Thr Ala Lys Phe Ala Leu Asn Gly Glu Glu Phe Met 
    130                 135                 140     


<210>  5207
<211>  167
<212>  PRT
<213>  Homo Sapiens

<400>  5207

Met Gly Val Pro Arg Pro Gln Pro Trp Ala Leu Gly Leu Leu Leu Phe 
1               5                   10                  15      


Leu Leu Pro Gly Ser Leu Gly Ala Glu Ser His Leu Ser Leu Leu Tyr 
            20                  25                  30          


His Leu Thr Ala Val Ser Ser Pro Ala Pro Gly Thr Pro Ala Phe Trp 
        35                  40                  45              


Val Ser Gly Trp Leu Gly Pro Gln Gln Tyr Leu Ser Tyr Asn Ser Leu 
    50                  55                  60                  


Arg Gly Glu Ala Glu Pro Cys Gly Ala Trp Val Trp Glu Asn Gln Val 
65                  70                  75                  80  


Ser Trp Tyr Trp Glu Lys Glu Thr Thr Asp Leu Arg Ile Lys Glu Lys 
                85                  90                  95      


Leu Phe Leu Glu Ala Phe Lys Ala Leu Gly Gly Lys Gly Pro Tyr Thr 
            100                 105                 110         


Leu Gln Gly Leu Leu Gly Cys Glu Leu Gly Pro Asp Asn Thr Ser Val 
        115                 120                 125             


Pro Thr Ala Lys Phe Ala Leu Asn Gly Glu Glu Phe Met Asn Phe Asp 
    130                 135                 140                 


Leu Lys Gln Gly Thr Trp Gly Gly Asp Trp Pro Glu Ala Leu Ala Ile 
145                 150                 155                 160 


Ser Gln Arg Trp Gln Gln Gln 
                165         


<210>  5208
<211>  225
<212>  PRT
<213>  Homo Sapiens

<400>  5208

Met Gly Val Pro Arg Pro Gln Pro Trp Ala Leu Gly Leu Leu Leu Phe 
1               5                   10                  15      


Leu Leu Pro Gly Ser Leu Gly Ala Glu Ser His Leu Ser Leu Leu Tyr 
            20                  25                  30          


His Leu Thr Ala Val Ser Ser Pro Ala Pro Gly Thr Pro Ala Phe Trp 
        35                  40                  45              


Val Ser Gly Trp Leu Gly Pro Gln Gln Tyr Leu Ser Tyr Asn Ser Leu 
    50                  55                  60                  


Arg Gly Glu Ala Glu Pro Cys Gly Ala Trp Val Trp Glu Asn Gln Val 
65                  70                  75                  80  


Ser Trp Tyr Trp Glu Lys Glu Thr Thr Asp Leu Arg Ile Lys Glu Lys 
                85                  90                  95      


Leu Phe Leu Glu Ala Phe Lys Ala Leu Gly Gly Lys Gly Pro Tyr Thr 
            100                 105                 110         


Leu Gln Gly Leu Leu Gly Cys Glu Leu Gly Pro Asp Asn Thr Ser Val 
        115                 120                 125             


Pro Thr Ala Lys Phe Ala Leu Asn Gly Glu Glu Phe Met Asn Phe Asp 
    130                 135                 140                 


Leu Lys Gln Gly Thr Trp Gly Gly Asp Trp Pro Glu Ala Leu Ala Ile 
145                 150                 155                 160 


Ser Gln Arg Trp Gln Gln Gln Asp Lys Ala Ala Asn Lys Glu Leu Thr 
                165                 170                 175     


Phe Leu Leu Phe Ser Cys Pro His Arg Leu Arg Glu His Leu Glu Arg 
            180                 185                 190         


Gly Arg Gly Asn Leu Glu Trp Lys Asp Thr Val Ser His Tyr Val Ala 
        195                 200                 205             


Gln Ala Gly Leu Glu Leu Leu Gly Ser Ser Asp Ser Pro Ala Leu Val 
    210                 215                 220                 


Ser 
225 


<210>  5209
<211>  365
<212>  PRT
<213>  Homo Sapiens

<400>  5209

Met Gly Val Pro Arg Pro Gln Pro Trp Ala Leu Gly Leu Leu Leu Phe 
1               5                   10                  15      


Leu Leu Pro Gly Ser Leu Gly Ala Glu Ser His Leu Ser Leu Leu Tyr 
            20                  25                  30          


His Leu Thr Ala Val Ser Ser Pro Ala Pro Gly Thr Pro Ala Phe Trp 
        35                  40                  45              


Val Ser Gly Trp Leu Gly Pro Gln Gln Tyr Leu Ser Tyr Asn Ser Leu 
    50                  55                  60                  


Arg Gly Glu Ala Glu Pro Cys Gly Ala Trp Val Trp Glu Asn Gln Val 
65                  70                  75                  80  


Ser Trp Tyr Trp Glu Lys Glu Thr Thr Asp Leu Arg Ile Lys Glu Lys 
                85                  90                  95      


Leu Phe Leu Glu Ala Phe Lys Ala Leu Gly Gly Lys Gly Pro Tyr Thr 
            100                 105                 110         


Leu Gln Gly Leu Leu Gly Cys Glu Leu Gly Pro Asp Asn Thr Ser Val 
        115                 120                 125             


Pro Thr Ala Lys Phe Ala Leu Asn Gly Glu Glu Phe Met Asn Phe Asp 
    130                 135                 140                 


Leu Lys Gln Gly Thr Trp Gly Gly Asp Trp Pro Glu Ala Leu Ala Ile 
145                 150                 155                 160 


Ser Gln Arg Trp Gln Gln Gln Asp Lys Ala Ala Asn Lys Glu Leu Thr 
                165                 170                 175     


Phe Leu Leu Phe Ser Cys Pro His Arg Leu Arg Glu His Leu Glu Arg 
            180                 185                 190         


Gly Arg Gly Asn Leu Glu Trp Lys Glu Pro Pro Ser Met Arg Leu Lys 
        195                 200                 205             


Ala Arg Pro Ser Ser Pro Gly Phe Ser Val Leu Thr Cys Ser Ala Phe 
    210                 215                 220                 


Ser Phe Tyr Pro Pro Glu Leu Gln Leu Arg Phe Leu Arg Asn Gly Leu 
225                 230                 235                 240 


Ala Ala Gly Thr Gly Gln Gly Asp Phe Gly Pro Asn Ser Asp Gly Ser 
                245                 250                 255     


Phe His Ala Ser Ser Ser Leu Thr Val Lys Ser Gly Asp Glu His His 
            260                 265                 270         


Tyr Cys Cys Ile Val Gln His Ala Gly Leu Ala Gln Pro Leu Arg Val 
        275                 280                 285             


Glu Leu Glu Ser Pro Ala Lys Ser Ser Val Leu Val Val Gly Ile Val 
    290                 295                 300                 


Ile Gly Val Leu Leu Leu Thr Ala Ala Ala Val Gly Gly Ala Leu Leu 
305                 310                 315                 320 


Trp Arg Arg Met Arg Ser Gly Leu Pro Ala Pro Trp Ile Ser Leu Arg 
                325                 330                 335     


Gly Asp Asp Thr Gly Val Leu Leu Pro Thr Pro Gly Glu Ala Gln Asp 
            340                 345                 350         


Ala Asp Leu Lys Asp Val Asn Val Ile Pro Ala Thr Ala 
        355                 360                 365 


<210>  5210
<211>  365
<212>  PRT
<213>  Homo Sapiens

<400>  5210

Met Gly Val Pro Arg Pro Gln Pro Trp Ala Leu Gly Leu Leu Leu Phe 
1               5                   10                  15      


Leu Leu Pro Gly Ser Leu Gly Ala Glu Ser His Leu Ser Leu Leu Tyr 
            20                  25                  30          


His Leu Thr Ala Val Ser Ser Pro Ala Pro Gly Thr Pro Ala Phe Trp 
        35                  40                  45              


Val Ser Gly Trp Leu Gly Pro Gln Gln Tyr Leu Ser Tyr Asn Ser Leu 
    50                  55                  60                  


Arg Gly Glu Ala Glu Pro Cys Gly Ala Trp Val Trp Glu Asn Gln Val 
65                  70                  75                  80  


Ser Trp Tyr Trp Glu Lys Glu Thr Thr Asp Leu Arg Ile Lys Glu Lys 
                85                  90                  95      


Leu Phe Leu Glu Ala Phe Lys Ala Leu Gly Gly Lys Gly Pro Tyr Thr 
            100                 105                 110         


Leu Gln Gly Leu Leu Gly Cys Glu Leu Gly Pro Asp Asn Thr Ser Val 
        115                 120                 125             


Pro Thr Ala Lys Phe Ala Leu Asn Gly Glu Glu Phe Met Asn Phe Asp 
    130                 135                 140                 


Leu Lys Gln Gly Thr Trp Gly Gly Asp Trp Pro Glu Ala Leu Ala Ile 
145                 150                 155                 160 


Ser Gln Arg Trp Gln Gln Gln Asp Lys Ala Ala Asn Lys Glu Leu Thr 
                165                 170                 175     


Phe Leu Leu Phe Ser Cys Pro His Arg Leu Arg Glu His Leu Glu Arg 
            180                 185                 190         


Gly Arg Gly Asn Leu Glu Trp Lys Glu Pro Pro Ser Met Arg Leu Lys 
        195                 200                 205             


Ala Arg Pro Ser Ser Pro Gly Phe Ser Val Leu Thr Cys Ser Ala Phe 
    210                 215                 220                 


Ser Phe Tyr Pro Pro Glu Leu Gln Leu Arg Phe Leu Arg Asn Gly Leu 
225                 230                 235                 240 


Ala Ala Gly Thr Gly Gln Gly Asp Phe Gly Pro Asn Ser Asp Gly Ser 
                245                 250                 255     


Phe His Ala Ser Ser Ser Leu Thr Val Lys Ser Gly Asp Glu His His 
            260                 265                 270         


Tyr Cys Cys Ile Val Gln His Ala Gly Leu Ala Gln Pro Leu Arg Val 
        275                 280                 285             


Glu Leu Glu Ser Pro Ala Lys Ser Ser Val Leu Val Val Gly Ile Val 
    290                 295                 300                 


Ile Gly Val Leu Leu Leu Thr Ala Ala Ala Val Gly Gly Ala Leu Leu 
305                 310                 315                 320 


Trp Arg Arg Met Arg Ser Gly Leu Pro Ala Pro Trp Ile Ser Leu Arg 
                325                 330                 335     


Gly Asp Asp Thr Gly Val Leu Leu Pro Thr Pro Gly Glu Ala Gln Asp 
            340                 345                 350         


Ala Asp Leu Lys Asp Val Asn Val Ile Pro Ala Thr Ala 
        355                 360                 365 


<210>  5211
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  5211

Met Gly Val Pro Arg Pro Gln Pro Trp Ala Leu Gly Leu Leu Leu Phe 
1               5                   10                  15      


Leu Leu Pro Gly Ser Leu Gly Ala Glu Ser Pro Ala Lys Ser Ser Val 
            20                  25                  30          


Leu Val Val Gly Ile Val Ile Gly Val Leu Leu Leu Thr Ala Ala Ala 
        35                  40                  45              


Val Gly Gly Ala Leu Leu Trp Arg Arg Met Arg Ser Gly Leu Pro Ala 
    50                  55                  60                  


Pro Trp Ile Ser Leu Arg Gly Asp Asp Thr Gly Val Leu Leu Pro Thr 
65                  70                  75                  80  


Pro Gly Glu Ala Gln Asp Ala Asp Leu Lys Asp Val Asn Val Ile Pro 
                85                  90                  95      


Ala Thr Ala 
            


<210>  5212
<211>  39
<212>  PRT
<213>  Homo Sapiens

<400>  5212

Met Asn Phe Asp Leu Lys Gln Gly Thr Trp Gly Gly Asp Trp Pro Glu 
1               5                   10                  15      


Ala Leu Ala Ile Ser Gln Arg Trp Gln Gln Gln Asp Lys Ala Ala Asn 
            20                  25                  30          


Lys Glu Leu Thr Phe Leu Leu 
        35                  


<210>  5213
<211>  153
<212>  PRT
<213>  Homo Sapiens

<400>  5213

Trp Glu Lys Glu Thr Thr Asp Leu Arg Ile Lys Glu Lys Leu Phe Leu 
1               5                   10                  15      


Glu Ala Phe Lys Ala Leu Gly Gly Lys Gly Pro Tyr Thr Leu Gln Gly 
            20                  25                  30          


Leu Leu Gly Cys Glu Leu Gly Pro Asp Asn Thr Ser Val Pro Thr Ala 
        35                  40                  45              


Lys Phe Ala Leu Asn Gly Glu Glu Phe Met Asn Phe Asp Leu Lys Gln 
    50                  55                  60                  


Gly Thr Trp Gly Gly Asp Trp Pro Glu Ala Leu Ala Ile Ser Gln Arg 
65                  70                  75                  80  


Trp Gln Gln Gln Asp Lys Ala Ala Asn Lys Glu Leu Thr Phe Leu Leu 
                85                  90                  95      


Phe Ser Cys Pro His Arg Leu Arg Glu His Leu Glu Arg Gly Arg Gly 
            100                 105                 110         


Asn Leu Glu Trp Lys Ala Pro Trp Ile Ser Leu Arg Gly Asp Asp Thr 
        115                 120                 125             


Gly Val Leu Leu Pro Thr Pro Gly Glu Ala Gln Asp Ala Asp Leu Lys 
    130                 135                 140                 


Asp Val Asn Val Ile Pro Ala Thr Ala 
145                 150             


<210>  5214
<211>  189
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5214

Xaa Ser Ser Pro Ala Pro Gly Thr Pro Ala Phe Trp Val Ser Gly Trp 
1               5                   10                  15      


Leu Gly Pro Gln Gln Tyr Leu Ser Tyr Asn Ser Leu Arg Gly Glu Ala 
            20                  25                  30          


Glu Pro Cys Gly Ala Trp Val Trp Glu Asn Gln Val Ser Trp Tyr Trp 
        35                  40                  45              


Glu Lys Glu Thr Thr Asp Leu Arg Ile Lys Glu Lys Leu Phe Leu Glu 
    50                  55                  60                  


Ala Phe Lys Ala Leu Gly Gly Lys Gly Pro Tyr Thr Leu Gln Gly Leu 
65                  70                  75                  80  


Leu Gly Cys Glu Leu Gly Pro Asp Asn Thr Ser Val Pro Thr Ala Lys 
                85                  90                  95      


Phe Ala Leu Asn Gly Glu Glu Phe Met Asn Phe Asp Leu Lys Gln Gly 
            100                 105                 110         


Thr Trp Gly Gly Asp Trp Pro Glu Ala Leu Ala Ile Ser Gln Arg Trp 
        115                 120                 125             


Gln Gln Gln Asp Lys Ala Ala Asn Lys Glu Leu Thr Phe Leu Leu Phe 
    130                 135                 140                 


Ser Cys Pro His Arg Leu Arg Glu His Leu Glu Arg Gly Arg Gly Asn 
145                 150                 155                 160 


Leu Glu Trp Lys Ala Pro Ser Pro Ser Thr Leu Arg Ser Cys Asn Phe 
                165                 170                 175     


Gly Ser Cys Gly Met Gly Trp Pro Leu Ala Pro Ala Arg 
            180                 185                 


<210>  5215
<211>  141
<212>  PRT
<213>  Homo Sapiens

<400>  5215

Met Asp Phe Trp Leu Trp Pro Leu Tyr Phe Leu Pro Glu Met Glu Ser 
1               5                   10                  15      


Cys Cys Val Ala Gln Asp Gly Leu Glu Leu Val Ala Leu Ser Asp Pro 
            20                  25                  30          


Pro Gly Ser Ala Ser Gln Ser Ala Gly Ile Thr Val Ser Gly Ala Leu 
        35                  40                  45              


Arg Ile Leu Pro Glu Val Lys Val Glu Gly Glu Leu Gly Gly Ser Val 
    50                  55                  60                  


Thr Ile Lys Cys Pro Leu Pro Glu Met His Val Arg Ile Tyr Leu Cys 
65                  70                  75                  80  


Arg Glu Met Ala Gly Ser Gly Thr Cys Gly Thr Val Val Ser Thr Thr 
                85                  90                  95      


Asn Phe Ile Lys Ala Glu Tyr Lys Gly Arg Val Thr Leu Lys Gln Tyr 
            100                 105                 110         


Pro Arg Lys Asn Leu Phe Leu Val Glu Val Thr Gln Leu Thr Glu Ser 
        115                 120                 125             


Asp Ser Gly Val Tyr Ala Cys Gly Ala Gly Met Asn Thr 
    130                 135                 140     


<210>  5216
<211>  278
<212>  PRT
<213>  Homo Sapiens

<400>  5216

Met Asp Phe Trp Leu Trp Pro Leu Tyr Phe Leu Pro Glu Tyr Glu Pro 
1               5                   10                  15      


Ser Trp Glu Glu Gln Pro Met Pro Glu Thr Pro Lys Trp Phe His Leu 
            20                  25                  30          


Pro Tyr Leu Phe Gln Met Pro Ala Tyr Ala Ser Ser Ser Lys Phe Val 
        35                  40                  45              


Thr Arg Val Thr Thr Pro Ala Gln Arg Gly Lys Val Pro Pro Val His 
    50                  55                  60                  


His Ser Ser Pro Thr Thr Gln Ile Thr His Arg Pro Arg Val Ser Arg 
65                  70                  75                  80  


Ala Ser Ser Val Ala Gly Asp Lys Pro Arg Thr Phe Leu Pro Ser Thr 
                85                  90                  95      


Thr Ala Ser Lys Ile Ser Ala Leu Glu Gly Leu Leu Lys Pro Gln Thr 
            100                 105                 110         


Pro Ser Tyr Asn His His Thr Arg Leu His Arg Gln Arg Ala Leu Asp 
        115                 120                 125             


Tyr Gly Ser Gln Ser Gly Arg Glu Gly Gln Gly Phe His Ile Leu Ile 
    130                 135                 140                 


Pro Thr Ile Leu Gly Leu Phe Leu Leu Ala Leu Leu Gly Leu Val Val 
145                 150                 155                 160 


Lys Arg Ala Val Glu Arg Arg Lys Ala Leu Ser Arg Arg Ala Arg Arg 
                165                 170                 175     


Leu Ala Val Arg Met Arg Ala Leu Glu Ser Ser Gln Arg Pro Arg Gly 
            180                 185                 190         


Ser Pro Arg Pro Arg Ser Gln Asn Asn Ile Tyr Ser Ala Cys Pro Arg 
        195                 200                 205             


Arg Ala Arg Gly Ala Asp Ala Ala Gly Thr Gly Glu Ala Pro Val Pro 
    210                 215                 220                 


Gly Pro Gly Ala Pro Leu Pro Pro Ala Pro Leu Gln Val Ser Glu Ser 
225                 230                 235                 240 


Pro Trp Leu His Ala Pro Ser Leu Lys Thr Ser Cys Glu Tyr Val Ser 
                245                 250                 255     


Leu Tyr His Gln Pro Ala Ala Met Met Glu Asp Ser Asp Ser Asp Asp 
            260                 265                 270         


Tyr Ile Asn Val Pro Ala 
        275             


<210>  5217
<211>  125
<212>  PRT
<213>  Homo Sapiens

<400>  5217

Met Asp Phe Trp Leu Trp Pro Leu Tyr Phe Leu Pro Val Ser Gly Ala 
1               5                   10                  15      


Leu Arg Ile Leu Pro Glu Val Lys Val Glu Gly Glu Leu Gly Gly Ser 
            20                  25                  30          


Val Thr Ile Lys Cys Pro Leu Pro Glu Met His Val Arg Ile Tyr Leu 
        35                  40                  45              


Cys Arg Glu Met Ala Gly Ser Gly Thr Cys Gly Thr Val Val Ser Thr 
    50                  55                  60                  


Thr Asn Phe Ile Lys Ala Glu Tyr Lys Gly Arg Val Thr Leu Lys Gln 
65                  70                  75                  80  


Tyr Pro Arg Lys Asn Leu Phe Leu Val Glu Asn Thr Ser His His Gly 
                85                  90                  95      


Lys Ser Ser Gln Cys Leu Arg Leu Gln Asn Gly Phe Ile Cys Pro Ile 
            100                 105                 110         


Cys Ser Arg Cys Leu His Met Pro Val Leu Pro Asn Ser 
        115                 120                 125 


<210>  5218
<211>  147
<212>  PRT
<213>  Homo Sapiens

<400>  5218

Met Asp Phe Trp Leu Trp Pro Leu Tyr Phe Leu Pro Val Ser Gly Ala 
1               5                   10                  15      


Leu Arg Ile Leu Pro Glu Val Lys Val Glu Gly Glu Leu Gly Gly Ser 
            20                  25                  30          


Val Thr Ile Lys Cys Pro Leu Pro Glu Met His Val Arg Ile Tyr Leu 
        35                  40                  45              


Cys Arg Glu Met Ala Gly Ser Gly Thr Cys Gly Thr Val Val Ser Thr 
    50                  55                  60                  


Thr Asn Phe Ile Lys Ala Glu Tyr Lys Gly Arg Val Thr Leu Lys Gln 
65                  70                  75                  80  


Tyr Pro Arg Lys Asn Leu Phe Leu Val Glu Val Thr Gln Leu Thr Glu 
                85                  90                  95      


Ser Asp Ser Gly Val Tyr Ala Cys Gly Ala Gly Met Asn Thr Asp Arg 
            100                 105                 110         


Gly Lys Thr Gln Lys Val Thr Leu Asn Val His Ser Glu Tyr Glu Pro 
        115                 120                 125             


Ser Trp Glu Glu Gln Pro Met Pro Glu Thr Pro Lys Trp Phe His Leu 
    130                 135                 140                 


Pro Tyr Leu 
145         


<210>  5219
<211>  151
<212>  PRT
<213>  Homo Sapiens

<400>  5219

Met Asp Phe Trp Leu Trp Pro Leu Tyr Phe Leu Pro Val Ser Gly Ala 
1               5                   10                  15      


Leu Arg Ile Leu Pro Glu Val Lys Val Glu Gly Glu Leu Gly Gly Ser 
            20                  25                  30          


Val Thr Ile Lys Cys Pro Leu Pro Glu Met His Val Arg Ile Tyr Leu 
        35                  40                  45              


Cys Arg Glu Met Ala Gly Ser Gly Thr Cys Gly Thr Val Val Ser Thr 
    50                  55                  60                  


Thr Asn Phe Ile Lys Ala Glu Tyr Lys Gly Arg Val Thr Leu Lys Gln 
65                  70                  75                  80  


Tyr Pro Arg Lys Asn Leu Phe Leu Val Glu Val Thr Gln Leu Thr Glu 
                85                  90                  95      


Ser Asp Ser Gly Val Tyr Ala Cys Gly Ala Gly Met Asn Thr Asp Arg 
            100                 105                 110         


Gly Lys Thr Gln Lys Val Thr Leu Asn Val His Ser Glu Tyr Glu Pro 
        115                 120                 125             


Ser Trp Glu Glu Gln Pro Met Pro Glu Thr Pro Lys Trp Phe His Leu 
    130                 135                 140                 


Pro Tyr Leu Phe Gln Met Pro 
145                 150     


<210>  5220
<211>  390
<212>  PRT
<213>  Homo Sapiens

<400>  5220

Met Asp Phe Trp Leu Trp Pro Leu Tyr Phe Leu Pro Val Ser Gly Ala 
1               5                   10                  15      


Leu Arg Ile Leu Pro Glu Val Lys Val Glu Gly Glu Leu Gly Gly Ser 
            20                  25                  30          


Val Thr Ile Lys Cys Pro Leu Pro Glu Met His Val Arg Ile Tyr Leu 
        35                  40                  45              


Cys Arg Glu Met Ala Gly Ser Gly Thr Cys Gly Thr Val Val Ser Thr 
    50                  55                  60                  


Thr Asn Phe Ile Lys Ala Glu Tyr Lys Gly Arg Val Thr Leu Lys Gln 
65                  70                  75                  80  


Tyr Pro Arg Lys Asn Leu Phe Leu Val Glu Val Thr Gln Leu Thr Glu 
                85                  90                  95      


Ser Asp Ser Gly Val Tyr Ala Cys Gly Ala Gly Met Asn Thr Asp Arg 
            100                 105                 110         


Gly Lys Thr Gln Lys Val Thr Leu Asn Val His Ser Glu Tyr Glu Pro 
        115                 120                 125             


Ser Trp Glu Glu Gln Pro Met Pro Glu Thr Pro Lys Trp Phe His Leu 
    130                 135                 140                 


Pro Tyr Leu Phe Gln Met Pro Ala Tyr Ala Ser Ser Ser Lys Phe Val 
145                 150                 155                 160 


Thr Arg Val Thr Thr Pro Ala Gln Arg Gly Lys Val Pro Pro Val His 
                165                 170                 175     


His Ser Ser Pro Thr Thr Gln Ile Thr His Arg Pro Arg Val Ser Arg 
            180                 185                 190         


Ala Ser Ser Val Ala Gly Asp Lys Pro Arg Thr Phe Leu Pro Ser Thr 
        195                 200                 205             


Thr Ala Ser Lys Ile Ser Ala Leu Glu Gly Leu Leu Lys Pro Gln Thr 
    210                 215                 220                 


Pro Ser Tyr Asn His His Thr Arg Leu His Arg Gln Arg Ala Leu Asp 
225                 230                 235                 240 


Tyr Gly Ser Gln Ser Gly Arg Glu Gly Gln Gly Phe His Ile Leu Ile 
                245                 250                 255     


Pro Thr Ile Leu Gly Leu Phe Leu Leu Ala Leu Leu Gly Leu Val Val 
            260                 265                 270         


Lys Arg Ala Val Glu Arg Arg Lys Ala Leu Ser Arg Arg Ala Arg Arg 
        275                 280                 285             


Leu Ala Val Arg Met Arg Ala Leu Glu Ser Ser Gln Arg Pro Arg Gly 
    290                 295                 300                 


Ser Pro Arg Pro Arg Ser Gln Asn Asn Ile Tyr Ser Ala Cys Pro Arg 
305                 310                 315                 320 


Arg Ala Arg Gly Ala Asp Ala Ala Gly Thr Gly Glu Ala Pro Val Pro 
                325                 330                 335     


Gly Pro Gly Ala Pro Leu Pro Pro Ala Pro Leu Gln Val Ser Glu Ser 
            340                 345                 350         


Pro Trp Leu His Ala Pro Ser Leu Lys Thr Ser Cys Glu Tyr Val Ser 
        355                 360                 365             


Leu Tyr His Gln Pro Ala Ala Met Met Glu Asp Ser Asp Ser Asp Asp 
    370                 375                 380                 


Tyr Ile Asn Val Pro Ala 
385                 390 


<210>  5221
<211>  306
<212>  PRT
<213>  Homo Sapiens

<400>  5221

Met Asp Phe Trp Leu Trp Pro Leu Tyr Phe Leu Pro Val Ser Gly Ala 
1               5                   10                  15      


Leu Arg Ile Leu Pro Glu Val Lys Val Glu Gly Glu Leu Gly Gly Ser 
            20                  25                  30          


Val Thr Ile Lys Cys Pro Leu Pro Glu Met His Val Arg Ile Tyr Leu 
        35                  40                  45              


Cys Arg Glu Met Ala Gly Ser Gly Thr Cys Gly Thr Val Val Ser Thr 
    50                  55                  60                  


Thr Asn Phe Ile Lys Ala Glu Tyr Lys Gly Arg Val Thr Leu Lys Gln 
65                  70                  75                  80  


Tyr Pro Arg Lys Asn Leu Phe Leu Val Glu Val Thr Gln Leu Thr Glu 
                85                  90                  95      


Ser Asp Ser Gly Val Tyr Ala Cys Gly Ala Gly Met Asn Thr Asp Arg 
            100                 105                 110         


Gly Lys Thr Gln Lys Val Thr Leu Asn Val His Ser Glu Tyr Glu Pro 
        115                 120                 125             


Ser Trp Glu Glu Gln Pro Met Pro Glu Thr Pro Lys Trp Phe His Leu 
    130                 135                 140                 


Pro Tyr Leu Phe Gln Met Pro Ala Tyr Ala Ser Ser Ser Lys Phe Val 
145                 150                 155                 160 


Thr Arg Val Thr Thr Pro Ala Gln Arg Gly Lys Val Pro Pro Val His 
                165                 170                 175     


His Ser Ser Pro Thr Thr Gln Ile Thr His Arg Pro Arg Val Ser Arg 
            180                 185                 190         


Ala Ser Ser Val Ala Gly Asp Lys Pro Arg Thr Phe Leu Pro Ser Thr 
        195                 200                 205             


Thr Ala Ser Lys Ile Ser Ala Leu Glu Gly Leu Leu Lys Pro Gln Thr 
    210                 215                 220                 


Pro Ser Tyr Asn His His Thr Arg Leu His Arg Gln Ser Pro Leu Gln 
225                 230                 235                 240 


Ala Gly Pro Pro Thr Gly Arg Glu Asp Ala Arg Pro Gly Glu Leu Pro 
                245                 250                 255     


Glu Ala Pro Arg Val Ala Ala Thr Ala Leu Pro Lys Gln His Leu Gln 
            260                 265                 270         


Arg Leu Pro Ala Ala Arg Ser Trp Ser Gly Arg Cys Arg His Arg Gly 
        275                 280                 285             


Gly Pro Arg Ser Arg Pro Arg Ser Ala Val Ala Pro Arg Pro Ala Ala 
    290                 295                 300                 


Gly Val 
305     


<210>  5222
<211>  326
<212>  PRT
<213>  Homo Sapiens

<400>  5222

Met Glu Leu Ser Gly Ala Thr Met Ala Arg Gly Leu Ala Val Leu Leu 
1               5                   10                  15      


Val Leu Phe Leu His Ile Lys Asn Leu Pro Ala Gln Ala Ala Asp Thr 
            20                  25                  30          


Cys Pro Glu Val Lys Val Val Gly Leu Glu Gly Ser Asp Lys Leu Thr 
        35                  40                  45              


Ile Leu Arg Gly Cys Pro Gly Leu Pro Gly Ala Pro Gly Pro Lys Gly 
    50                  55                  60                  


Glu Ala Gly Val Ile Gly Glu Arg Gly Glu Arg Gly Leu Pro Gly Ala 
65                  70                  75                  80  


Pro Gly Lys Ala Gly Pro Val Gly Pro Lys Gly Asp Arg Gly Glu Lys 
                85                  90                  95      


Gly Met Arg Gly Glu Lys Gly Asp Ala Gly Gln Ser Gln Ser Cys Ala 
            100                 105                 110         


Thr Gly Pro Arg Asn Cys Lys Asp Leu Leu Asp Arg Gly Tyr Phe Leu 
        115                 120                 125             


Ser Gly Trp His Thr Ile Tyr Leu Pro Asp Cys Arg Pro Leu Thr Val 
    130                 135                 140                 


Leu Cys Asp Met Asp Thr Asp Gly Gly Gly Trp Thr Val Phe Gln Arg 
145                 150                 155                 160 


Arg Met Asp Gly Ser Val Asp Phe Tyr Arg Asp Trp Ala Ala Tyr Lys 
                165                 170                 175     


Gln Gly Phe Gly Ser Gln Leu Gly Glu Phe Trp Leu Gly Asn Asp Asn 
            180                 185                 190         


Ile His Ala Leu Thr Ala Gln Gly Ser Ser Glu Leu Arg Val Asp Leu 
        195                 200                 205             


Val Asp Phe Glu Gly Asn His Gln Phe Ala Lys Tyr Lys Ser Phe Lys 
    210                 215                 220                 


Val Ala Asp Glu Ala Glu Lys Tyr Lys Leu Val Leu Gly Ala Phe Val 
225                 230                 235                 240 


Gly Gly Ser Ala Gly Asn Ser Leu Thr Gly His Asn Asn Asn Phe Phe 
                245                 250                 255     


Ser Thr Lys Asp Gln Asp Asn Asp Val Ser Ser Ser Asn Cys Ala Glu 
            260                 265                 270         


Lys Phe Gln Gly Ala Trp Trp Tyr Ala Asp Cys His Ala Ser Asn Leu 
        275                 280                 285             


Asn Gly Leu Tyr Leu Met Gly Pro His Glu Ser Tyr Ala Asn Gly Ile 
    290                 295                 300                 


Asn Trp Ser Ala Ala Lys Gly Tyr Lys Tyr Ser Tyr Lys Val Ser Glu 
305                 310                 315                 320 


Met Lys Val Arg Pro Ala 
                325     


<210>  5223
<211>  360
<212>  PRT
<213>  Homo Sapiens

<400>  5223

Met Glu Leu Ser Gly Ala Thr Met Ala Arg Gly Leu Ala Val Leu Leu 
1               5                   10                  15      


Val Leu Phe Leu His Ile Lys Asn Leu Pro Ala Gln Ala Ala Asp Thr 
            20                  25                  30          


Cys Pro Glu Val Lys Val Val Gly Leu Glu Gly Ser Asp Lys Leu Thr 
        35                  40                  45              


Ile Leu Arg Gly Cys Pro Gly Leu Pro Gly Ala Pro Gly Pro Lys Gly 
    50                  55                  60                  


Glu Ala Gly Val Ile Gly Glu Arg Gly Glu Arg Gly Leu Pro Gly Ala 
65                  70                  75                  80  


Pro Gly Lys Ala Gly Pro Val Gly Pro Lys Gly Asp Arg Gly Glu Lys 
                85                  90                  95      


Gly Met Arg Gly Glu Lys Gly Asp Ala Gly Gln Ser Gln Ser Cys Ala 
            100                 105                 110         


Thr Gly Pro Arg Asn Cys Lys Asp Leu Leu Asp Arg Gly Tyr Phe Leu 
        115                 120                 125             


Ser Gly Trp His Thr Ile Tyr Leu Pro Asp Cys Arg Pro Leu Thr Val 
    130                 135                 140                 


Leu Cys Asp Met Asp Thr Asp Gly Gly Gly Trp Thr Val Phe Gln Arg 
145                 150                 155                 160 


Arg Met Asp Gly Ser Val Asp Phe Tyr Arg Asp Trp Ala Ala Tyr Lys 
                165                 170                 175     


Gln Gly Phe Gly Ser Gln Thr His Ser His Asp Ala His Ser Cys Pro 
            180                 185                 190         


Phe Ala Pro Ser Ser Val Lys Pro Pro His Ala His Asn Leu Thr Arg 
        195                 200                 205             


Gly Arg Ile Met Phe Leu Asn Met Phe Thr Leu Gly Gln Lys Ser Phe 
    210                 215                 220                 


Thr Ser Phe Asn Val Cys Phe Leu Asn Thr Ser Gly Phe Asp His Phe 
225                 230                 235                 240 


Pro Val Ser Val Ala Arg Gln Val Phe Pro Trp Asn Leu Val Ser Arg 
                245                 250                 255     


Glu Glu Ser Gly Pro Leu Phe Ser Arg Trp His Tyr Arg Cys Ser Gly 
            260                 265                 270         


Arg Leu Ser Asp Phe Cys Glu Asp Phe Pro Pro Pro Val Ile Asp Thr 
        275                 280                 285             


Gly Arg Ser Ser Pro Pro Pro Pro Ser Leu Pro His Pro Pro Met Pro 
    290                 295                 300                 


His Ser Gln His Phe Thr Leu Leu Glu Lys Gly His Phe Gly Val Gln 
305                 310                 315                 320 


Lys Thr Leu Thr Lys Lys Gly Glu Ser Leu Val Gly Thr Phe Leu Leu 
                325                 330                 335     


Pro Thr Thr Ala Glu Phe Met Leu Trp Ala Gly Trp Leu Leu Gly Arg 
            340                 345                 350         


Asp Lys His Leu Ala Leu Thr Lys 
        355                 360 


<210>  5224
<211>  313
<212>  PRT
<213>  Homo Sapiens

<400>  5224

Met Glu Leu Asp Arg Ala Val Gly Val Leu Gly Ala Ala Thr Leu Leu 
1               5                   10                  15      


Leu Ser Phe Leu Gly Met Ala Trp Ala Leu Gln Ala Ala Asp Thr Cys 
            20                  25                  30          


Pro Glu Val Lys Met Val Gly Leu Glu Gly Ser Asp Lys Leu Thr Ile 
        35                  40                  45              


Leu Arg Gly Cys Pro Gly Leu Pro Gly Ala Pro Gly Pro Lys Gly Glu 
    50                  55                  60                  


Ala Gly Thr Asn Gly Lys Arg Gly Glu Arg Gly Pro Pro Gly Pro Pro 
65                  70                  75                  80  


Gly Lys Ala Gly Pro Pro Gly Pro Asn Gly Ala Pro Gly Glu Pro Gln 
                85                  90                  95      


Pro Cys Leu Thr Gly Pro Arg Thr Cys Lys Asp Leu Leu Asp Arg Gly 
            100                 105                 110         


His Phe Leu Ser Gly Trp His Thr Ile Tyr Leu Pro Asp Cys Arg Pro 
        115                 120                 125             


Leu Thr Val Leu Cys Asp Met Asp Thr Asp Gly Gly Gly Trp Thr Val 
    130                 135                 140                 


Phe Gln Arg Arg Val Asp Gly Ser Val Asp Phe Tyr Arg Asp Trp Ala 
145                 150                 155                 160 


Thr Tyr Lys Gln Gly Phe Gly Ser Arg Leu Gly Glu Phe Trp Leu Gly 
                165                 170                 175     


Asn Asp Asn Ile His Ala Leu Thr Ala Gln Gly Thr Ser Glu Leu Arg 
            180                 185                 190         


Val Asp Leu Val Asp Phe Glu Asp Asn Tyr Gln Phe Ala Lys Tyr Arg 
        195                 200                 205             


Ser Phe Lys Val Ala Asp Glu Ala Glu Lys Tyr Asn Leu Val Leu Gly 
    210                 215                 220                 


Ala Phe Val Glu Gly Ser Ala Gly Asp Ser Leu Thr Phe His Asn Asn 
225                 230                 235                 240 


Gln Ser Phe Ser Thr Lys Asp Gln Asp Asn Asp Leu Asn Thr Gly Asn 
                245                 250                 255     


Cys Ala Val Met Phe Gln Gly Ala Trp Trp Tyr Lys Asn Cys His Val 
            260                 265                 270         


Ser Asn Leu Asn Gly Arg Tyr Leu Arg Gly Thr His Gly Ser Phe Ala 
        275                 280                 285             


Asn Gly Ile Asn Trp Lys Ser Gly Lys Gly Tyr Asn Tyr Ser Tyr Lys 
    290                 295                 300                 


Val Ser Glu Met Lys Val Arg Pro Ala 
305                 310             


<210>  5225
<211>  275
<212>  PRT
<213>  Homo Sapiens

<400>  5225

Met Glu Leu Asp Arg Ala Val Gly Val Leu Gly Ala Ala Thr Leu Leu 
1               5                   10                  15      


Leu Ser Phe Leu Gly Met Ala Trp Ala Leu Gln Ala Ala Asp Thr Cys 
            20                  25                  30          


Pro Gly Glu Arg Gly Pro Pro Gly Pro Pro Gly Lys Ala Gly Pro Pro 
        35                  40                  45              


Gly Pro Asn Gly Ala Pro Gly Glu Pro Gln Pro Cys Leu Thr Gly Pro 
    50                  55                  60                  


Arg Thr Cys Lys Asp Leu Leu Asp Arg Gly His Phe Leu Ser Gly Trp 
65                  70                  75                  80  


His Thr Ile Tyr Leu Pro Asp Cys Arg Pro Leu Thr Val Leu Cys Asp 
                85                  90                  95      


Met Asp Thr Asp Gly Gly Gly Trp Thr Val Phe Gln Arg Arg Val Asp 
            100                 105                 110         


Gly Ser Val Asp Phe Tyr Arg Asp Trp Ala Thr Tyr Lys Gln Gly Phe 
        115                 120                 125             


Gly Ser Arg Leu Gly Glu Phe Trp Leu Gly Asn Asp Asn Ile His Ala 
    130                 135                 140                 


Leu Thr Ala Gln Gly Thr Ser Glu Leu Arg Val Asp Leu Val Asp Phe 
145                 150                 155                 160 


Glu Asp Asn Tyr Gln Phe Ala Lys Tyr Arg Ser Phe Lys Val Ala Asp 
                165                 170                 175     


Glu Ala Glu Lys Tyr Asn Leu Val Leu Gly Ala Phe Val Glu Gly Ser 
            180                 185                 190         


Ala Gly Asp Ser Leu Thr Phe His Asn Asn Gln Ser Phe Ser Thr Lys 
        195                 200                 205             


Asp Gln Asp Asn Asp Leu Asn Thr Gly Asn Cys Ala Val Met Phe Gln 
    210                 215                 220                 


Gly Ala Trp Trp Tyr Lys Asn Cys His Val Ser Asn Leu Asn Gly Arg 
225                 230                 235                 240 


Tyr Leu Arg Gly Thr His Gly Ser Phe Ala Asn Gly Ile Asn Trp Lys 
                245                 250                 255     


Ser Gly Lys Gly Tyr Asn Tyr Ser Tyr Lys Val Ser Glu Met Lys Val 
            260                 265                 270         


Arg Pro Ala 
        275 


<210>  5226
<211>  299
<212>  PRT
<213>  Homo Sapiens

<400>  5226

Met Asp Leu Leu Trp Ile Leu Pro Ser Leu Trp Leu Leu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ala Cys Leu Lys Thr Gln Glu His Pro Ser Cys Pro Gly Pro 
            20                  25                  30          


Arg Glu Leu Glu Ala Ser Lys Val Val Leu Leu Pro Ser Cys Pro Gly 
        35                  40                  45              


Ala Pro Gly Ser Pro Gly Glu Lys Gly Ala Pro Gly Pro Gln Gly Pro 
    50                  55                  60                  


Pro Gly Pro Pro Gly Lys Met Gly Pro Lys Gly Glu Pro Gly Asp Pro 
65                  70                  75                  80  


Val Asn Leu Leu Arg Cys Gln Glu Gly Pro Arg Asn Cys Arg Glu Leu 
                85                  90                  95      


Leu Ser Gln Gly Ala Thr Leu Ser Gly Trp Tyr His Leu Cys Leu Pro 
            100                 105                 110         


Glu Gly Arg Ala Leu Pro Val Phe Cys Asp Met Asp Thr Glu Gly Gly 
        115                 120                 125             


Gly Trp Leu Val Phe Gln Arg Arg Gln Asp Gly Ser Val Asp Phe Phe 
    130                 135                 140                 


Arg Ser Trp Ser Ser Tyr Arg Ala Gly Phe Gly Asn Gln Glu Ser Glu 
145                 150                 155                 160 


Phe Trp Leu Gly Asn Glu Asn Leu His Gln Leu Thr Leu Gln Gly Asn 
                165                 170                 175     


Trp Glu Leu Arg Val Glu Leu Glu Asp Phe Asn Gly Asn Arg Thr Phe 
            180                 185                 190         


Ala His Tyr Ala Thr Phe Arg Leu Leu Gly Glu Val Asp His Tyr Gln 
        195                 200                 205             


Leu Ala Leu Gly Lys Phe Ser Glu Gly Thr Ala Gly Asp Ser Leu Ser 
    210                 215                 220                 


Leu His Ser Gly Arg Pro Phe Thr Thr Tyr Asp Ala Asp His Asp Ser 
225                 230                 235                 240 


Ser Asn Ser Asn Cys Ala Val Ile Val His Gly Ala Trp Trp Tyr Ala 
                245                 250                 255     


Ser Cys Tyr Arg Ser Asn Leu Asn Gly Arg Tyr Ala Val Ser Glu Ala 
            260                 265                 270         


Ala Ala His Lys Tyr Gly Ile Asp Trp Ala Ser Gly Arg Gly Val Gly 
        275                 280                 285             


His Pro Tyr Arg Arg Val Arg Met Met Leu Arg 
    290                 295                 


<210>  5227
<211>  288
<212>  PRT
<213>  Homo Sapiens

<400>  5227

Met Asp Leu Leu Trp Ile Leu Pro Ser Leu Trp Leu Leu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ala Cys Leu Lys Thr Gln Glu His Pro Ser Cys Pro Gly Pro 
            20                  25                  30          


Arg Glu Leu Glu Ala Ser Lys Val Val Leu Leu Pro Ser Cys Pro Gly 
        35                  40                  45              


Ala Pro Gly Ser Pro Gly Glu Lys Gly Ala Pro Gly Pro Gln Gly Pro 
    50                  55                  60                  


Pro Gly Pro Pro Gly Lys Met Gly Pro Lys Gly Glu Pro Gly Pro Arg 
65                  70                  75                  80  


Asn Cys Arg Glu Leu Leu Ser Gln Gly Ala Thr Leu Ser Gly Trp Tyr 
                85                  90                  95      


His Leu Cys Leu Pro Glu Gly Arg Ala Leu Pro Val Phe Cys Asp Met 
            100                 105                 110         


Asp Thr Glu Gly Gly Gly Trp Leu Val Phe Gln Arg Arg Gln Asp Gly 
        115                 120                 125             


Ser Val Asp Phe Phe Arg Ser Trp Ser Ser Tyr Arg Ala Gly Phe Gly 
    130                 135                 140                 


Asn Gln Glu Ser Glu Phe Trp Leu Gly Asn Glu Asn Leu His Gln Leu 
145                 150                 155                 160 


Thr Leu Gln Gly Asn Trp Glu Leu Arg Val Glu Leu Glu Asp Phe Asn 
                165                 170                 175     


Gly Asn Arg Thr Phe Ala His Tyr Ala Thr Phe Arg Leu Leu Gly Glu 
            180                 185                 190         


Val Asp His Tyr Gln Leu Ala Leu Gly Lys Phe Ser Glu Gly Thr Ala 
        195                 200                 205             


Gly Asp Ser Leu Ser Leu His Ser Gly Arg Pro Phe Thr Thr Tyr Asp 
    210                 215                 220                 


Ala Asp His Asp Ser Ser Asn Ser Asn Cys Ala Val Ile Val His Gly 
225                 230                 235                 240 


Ala Trp Trp Tyr Ala Ser Cys Tyr Arg Ser Asn Leu Asn Gly Arg Tyr 
                245                 250                 255     


Ala Val Ser Glu Ala Ala Ala His Lys Tyr Gly Ile Asp Trp Ala Ser 
            260                 265                 270         


Gly Arg Gly Val Gly His Pro Tyr Arg Arg Val Arg Met Met Leu Arg 
        275                 280                 285             


<210>  5228
<211>  429
<212>  PRT
<213>  Homo Sapiens

<400>  5228

Met Leu Pro Arg Leu Leu Leu Leu Ile Cys Ala Pro Leu Cys Glu Pro 
1               5                   10                  15      


Ala Glu Leu Phe Leu Ile Ala Ser Pro Ser His Pro Thr Glu Gly Ser 
            20                  25                  30          


Pro Val Thr Leu Thr Cys Lys Met Pro Phe Leu Gln Ser Ser Asp Ala 
        35                  40                  45              


Gln Phe Gln Phe Cys Phe Phe Arg Asp Thr Arg Ala Leu Gly Pro Gly 
    50                  55                  60                  


Trp Ser Ser Ser Pro Lys Leu Gln Ile Ala Ala Met Trp Lys Glu Asp 
65                  70                  75                  80  


Thr Gly Ser Tyr Trp Cys Glu Ala Gln Thr Met Ala Ser Lys Val Leu 
                85                  90                  95      


Arg Ser Arg Arg Ser Gln Ile Asn Val His Arg Val Pro Val Ala Asp 
            100                 105                 110         


Val Ser Leu Glu Thr Gln Pro Pro Gly Gly Gln Val Met Glu Gly Asp 
        115                 120                 125             


Arg Leu Val Leu Ile Cys Ser Val Ala Met Gly Thr Gly Asp Ile Thr 
    130                 135                 140                 


Phe Leu Trp Tyr Lys Gly Ala Val Gly Leu Asn Leu Gln Ser Lys Thr 
145                 150                 155                 160 


Gln Arg Ser Leu Thr Ala Glu Tyr Glu Ile Pro Ser Val Arg Glu Ser 
                165                 170                 175     


Asp Ala Glu Gln Tyr Tyr Cys Val Ala Glu Asn Gly Tyr Gly Pro Ser 
            180                 185                 190         


Pro Ser Gly Leu Val Ser Ile Thr Val Arg Ile Pro Val Ser Arg Pro 
        195                 200                 205             


Ile Leu Met Leu Arg Ala Pro Arg Ala Gln Ala Ala Val Glu Asp Val 
    210                 215                 220                 


Leu Glu Leu His Cys Glu Ala Leu Arg Gly Ser Pro Pro Ile Leu Tyr 
225                 230                 235                 240 


Trp Phe Tyr His Glu Asp Ile Thr Leu Gly Ser Arg Ser Ala Pro Ser 
                245                 250                 255     


Gly Gly Gly Ala Ser Phe Asn Leu Ser Leu Thr Glu Glu His Ser Gly 
            260                 265                 270         


Asn Tyr Ser Cys Glu Ala Asn Asn Gly Leu Gly Ala Gln Arg Ser Glu 
        275                 280                 285             


Ala Val Thr Leu Asn Phe Thr Val Pro Thr Gly Ala Arg Ser Asn His 
    290                 295                 300                 


Leu Thr Ser Gly Val Ile Glu Gly Leu Leu Ser Thr Leu Gly Pro Ala 
305                 310                 315                 320 


Thr Val Ala Leu Leu Phe Cys Tyr Gly Leu Lys Arg Lys Ile Gly Arg 
                325                 330                 335     


Arg Ser Ala Arg Asp Pro Leu Arg Ser Leu Pro Ser Pro Leu Pro Gln 
            340                 345                 350         


Glu Phe Thr Tyr Leu Asn Ser Pro Thr Pro Gly Gln Leu Gln Pro Ile 
        355                 360                 365             


Tyr Glu Asn Val Asn Val Val Ser Gly Asp Glu Val Tyr Ser Leu Ala 
    370                 375                 380                 


Tyr Tyr Asn Gln Pro Glu Gln Glu Ser Val Ala Ala Glu Thr Leu Gly 
385                 390                 395                 400 


Thr His Met Glu Asp Lys Val Ser Leu Asp Ile Tyr Ser Arg Leu Arg 
                405                 410                 415     


Lys Ala Asn Ile Thr Asp Val Asp Tyr Glu Asp Ala Met 
            420                 425                 


<210>  5229
<211>  366
<212>  PRT
<213>  Homo Sapiens

<400>  5229

Met Leu Pro Arg Leu Leu Leu Leu Ile Cys Ala Pro Leu Cys Glu Pro 
1               5                   10                  15      


Ala Glu Leu Phe Leu Ile Ala Ser Pro Ser His Pro Thr Glu Gly Ser 
            20                  25                  30          


Pro Val Thr Leu Thr Cys Lys Met Pro Phe Leu Gln Ser Ser Asp Ala 
        35                  40                  45              


Gln Phe Gln Phe Cys Phe Phe Arg Asp Thr Arg Ala Leu Gly Pro Gly 
    50                  55                  60                  


Trp Ser Ser Ser Pro Lys Leu Gln Ile Ala Ala Met Trp Lys Glu Asp 
65                  70                  75                  80  


Thr Gly Ser Tyr Trp Cys Glu Ala Gln Thr Met Ala Ser Lys Val Leu 
                85                  90                  95      


Arg Ser Arg Arg Ser Gln Ile Asn Val His Arg Val Pro Val Ala Asp 
            100                 105                 110         


Val Ser Leu Glu Thr Gln Pro Pro Gly Gly Gln Val Met Glu Gly Asp 
        115                 120                 125             


Arg Leu Val Leu Ile Cys Ser Val Ala Met Gly Thr Gly Asp Ile Thr 
    130                 135                 140                 


Phe Leu Trp Tyr Lys Gly Ala Val Gly Leu Asn Leu Gln Ser Lys Thr 
145                 150                 155                 160 


Gln Arg Ser Leu Thr Ala Glu Tyr Glu Ile Pro Ser Val Arg Glu Ser 
                165                 170                 175     


Asp Ala Glu Gln Tyr Tyr Cys Val Ala Glu Asn Gly Tyr Gly Pro Ser 
            180                 185                 190         


Pro Ser Gly Leu Val Ser Ile Thr Val Arg Ile Pro Val Ser Arg Pro 
        195                 200                 205             


Ile Leu Met Leu Arg Ala Pro Arg Ala Gln Ala Ala Val Glu Asp Val 
    210                 215                 220                 


Leu Glu Leu His Cys Glu Ala Leu Arg Gly Ser Pro Pro Ile Leu Tyr 
225                 230                 235                 240 


Trp Phe Tyr His Glu Asp Ile Thr Leu Gly Ser Arg Ser Ala Pro Ser 
                245                 250                 255     


Gly Gly Gly Ala Ser Phe Asn Leu Ser Leu Thr Glu Glu His Ser Gly 
            260                 265                 270         


Asn Tyr Ser Cys Glu Ala Asn Asn Gly Leu Gly Ala Gln Arg Ser Glu 
        275                 280                 285             


Ala Val Thr Leu Asn Phe Thr Gly Arg Arg Ser Ala Arg Asp Pro Leu 
    290                 295                 300                 


Arg Ser Leu Pro Ser Pro Leu Pro Gln Glu Phe Thr Tyr Leu Asn Ser 
305                 310                 315                 320 


Pro Thr Pro Gly Gln Leu Gln Pro Ile Tyr Glu Asn Glu Pro Arg Glu 
                325                 330                 335     


Gln Ser Val Ala Val His Gly Arg Gln Gln His Ser Ser Glu Gln Lys 
            340                 345                 350         


Ala Gln Lys Pro Trp Gly His Ile Trp Arg Thr Arg Phe Pro 
        355                 360                 365     


<210>  5230
<211>  428
<212>  PRT
<213>  Homo Sapiens

<400>  5230

Met Leu Pro Arg Leu Leu Leu Leu Ile Cys Ala Pro Leu Cys Glu Pro 
1               5                   10                  15      


Ala Glu Leu Phe Leu Ile Ala Ser Pro Ser His Pro Thr Glu Gly Ser 
            20                  25                  30          


Pro Val Thr Leu Thr Cys Lys Met Pro Phe Leu Gln Ser Ser Asp Ala 
        35                  40                  45              


Gln Phe Gln Phe Cys Phe Phe Arg Asp Thr Arg Ala Leu Gly Pro Gly 
    50                  55                  60                  


Trp Ser Ser Ser Pro Lys Leu Gln Ile Ala Ala Met Trp Lys Glu Asp 
65                  70                  75                  80  


Thr Gly Ser Tyr Trp Cys Glu Ala Gln Thr Met Ala Ser Lys Val Leu 
                85                  90                  95      


Arg Ser Arg Arg Ser Gln Ile Asn Val His Arg Val Pro Val Ala Asp 
            100                 105                 110         


Val Ser Leu Glu Thr Gln Pro Pro Gly Gly Gln Val Met Glu Gly Asp 
        115                 120                 125             


Arg Leu Val Leu Ile Cys Ser Val Ala Met Gly Thr Gly Asp Ile Thr 
    130                 135                 140                 


Phe Leu Trp Tyr Lys Gly Ala Val Gly Leu Asn Leu Gln Ser Lys Thr 
145                 150                 155                 160 


Gln Arg Ser Leu Thr Ala Glu Tyr Glu Ile Pro Ser Val Arg Glu Ser 
                165                 170                 175     


Asp Ala Glu Gln Tyr Tyr Cys Val Ala Glu Asn Gly Tyr Gly Pro Ser 
            180                 185                 190         


Pro Ser Gly Leu Val Ser Ile Thr Val Arg Ile Pro Val Ser Arg Pro 
        195                 200                 205             


Ile Leu Met Leu Arg Ala Pro Arg Ala Gln Ala Ala Val Glu Asp Val 
    210                 215                 220                 


Leu Glu Leu His Cys Glu Ala Leu Arg Gly Ser Pro Pro Ile Leu Tyr 
225                 230                 235                 240 


Trp Phe Tyr His Glu Asp Ile Thr Leu Gly Ser Arg Ser Ala Pro Ser 
                245                 250                 255     


Gly Gly Gly Ala Ser Phe Asn Leu Ser Leu Thr Glu Glu His Ser Gly 
            260                 265                 270         


Asn Tyr Ser Cys Glu Ala Asn Asn Gly Leu Gly Ala Gln Arg Ser Glu 
        275                 280                 285             


Ala Val Thr Leu Asn Phe Thr Val Pro Thr Gly Ala Arg Ser Asn His 
    290                 295                 300                 


Leu Thr Ser Gly Val Ile Glu Gly Leu Leu Ser Thr Leu Gly Pro Ala 
305                 310                 315                 320 


Thr Val Ala Leu Leu Phe Cys Tyr Gly Leu Lys Arg Lys Ile Gly Arg 
                325                 330                 335     


Arg Ser Ala Arg Asp Pro Leu Arg Ser Leu Pro Ser Pro Leu Pro Gln 
            340                 345                 350         


Glu Phe Thr Tyr Leu Asn Ser Pro Thr Pro Gly Gln Leu Gln Pro Ile 
        355                 360                 365             


Tyr Glu Asn Val Asn Val Val Ser Gly Asp Glu Val Tyr Ser Leu Ala 
    370                 375                 380                 


Tyr Tyr Asn Gln Pro Glu Gln Glu Ser Val Ala Glu Thr Leu Gly Thr 
385                 390                 395                 400 


His Met Glu Asp Lys Val Ser Leu Asp Ile Tyr Ser Arg Leu Arg Lys 
                405                 410                 415     


Ala Asn Ile Thr Asp Val Asp Tyr Glu Asp Ala Met 
            420                 425             


<210>  5231
<211>  742
<212>  PRT
<213>  Homo Sapiens

<400>  5231

Met Leu Leu Trp Leu Leu Leu Leu Ile Leu Thr Pro Gly Arg Glu Gln 
1               5                   10                  15      


Ser Gly Val Ala Pro Lys Ala Val Leu Leu Leu Asn Pro Pro Trp Ser 
            20                  25                  30          


Thr Ala Phe Lys Gly Glu Lys Val Ala Leu Ile Cys Ser Ser Ile Ser 
        35                  40                  45              


His Ser Leu Ala Gln Gly Asp Thr Tyr Trp Tyr His Asp Glu Lys Leu 
    50                  55                  60                  


Leu Lys Ile Lys His Asp Lys Ile Gln Ile Thr Glu Pro Gly Asn Tyr 
65                  70                  75                  80  


Gln Cys Lys Thr Arg Gly Ser Ser Leu Ser Asp Ala Val His Val Glu 
                85                  90                  95      


Phe Ser Pro Asp Trp Leu Ile Leu Gln Ala Leu His Pro Val Phe Glu 
            100                 105                 110         


Gly Asp Asn Val Ile Leu Arg Cys Gln Gly Lys Asp Asn Lys Asn Thr 
        115                 120                 125             


His Gln Lys Val Tyr Tyr Lys Asp Gly Lys Gln Leu Pro Asn Ser Tyr 
    130                 135                 140                 


Asn Leu Glu Lys Ile Thr Val Asn Ser Val Ser Arg Asp Asn Ser Lys 
145                 150                 155                 160 


Tyr His Cys Thr Ala Tyr Arg Lys Phe Tyr Ile Leu Asp Ile Glu Val 
                165                 170                 175     


Thr Ser Lys Pro Leu Asn Ile Gln Val Gln Glu Leu Phe Leu His Pro 
            180                 185                 190         


Val Leu Arg Ala Ser Ser Ser Thr Pro Ile Glu Gly Ser Pro Met Thr 
        195                 200                 205             


Leu Thr Cys Glu Thr Gln Leu Ser Pro Gln Arg Pro Asp Val Gln Leu 
    210                 215                 220                 


Gln Phe Ser Leu Phe Arg Asp Ser Gln Thr Leu Gly Leu Gly Trp Ser 
225                 230                 235                 240 


Arg Ser Pro Arg Leu Gln Ile Pro Ala Met Trp Thr Glu Asp Ser Gly 
                245                 250                 255     


Ser Tyr Trp Cys Glu Val Glu Thr Val Thr His Ser Ile Lys Lys Arg 
            260                 265                 270         


Ser Leu Arg Ser Gln Ile Arg Val Gln Arg Val Pro Val Ser Asn Val 
        275                 280                 285             


Asn Leu Glu Ile Arg Pro Thr Gly Gly Gln Leu Ile Glu Gly Glu Asn 
    290                 295                 300                 


Met Val Leu Ile Cys Ser Val Ala Gln Gly Ser Gly Thr Val Thr Phe 
305                 310                 315                 320 


Ser Trp His Lys Glu Gly Arg Val Arg Ser Leu Gly Arg Lys Thr Gln 
                325                 330                 335     


Arg Ser Leu Leu Ala Glu Leu His Val Leu Thr Val Lys Glu Ser Asp 
            340                 345                 350         


Ala Gly Arg Tyr Tyr Cys Ala Ala Asp Asn Val His Ser Pro Ile Leu 
        355                 360                 365             


Ser Thr Trp Ile Arg Val Thr Val Arg Ile Pro Val Ser His Pro Val 
    370                 375                 380                 


Leu Thr Phe Arg Ala Pro Arg Ala His Thr Val Val Gly Asp Leu Leu 
385                 390                 395                 400 


Glu Leu His Cys Glu Ser Leu Arg Gly Ser Pro Pro Ile Leu Tyr Arg 
                405                 410                 415     


Phe Tyr His Glu Asp Val Thr Leu Gly Asn Ser Ser Ala Pro Ser Gly 
            420                 425                 430         


Gly Gly Ala Ser Phe Asn Leu Ser Leu Thr Ala Glu His Ser Gly Asn 
        435                 440                 445             


Tyr Ser Cys Asp Ala Asp Asn Gly Leu Gly Ala Gln His Ser His Gly 
    450                 455                 460                 


Val Ser Leu Arg Val Thr Val Pro Val Ser Arg Pro Val Leu Thr Leu 
465                 470                 475                 480 


Arg Ala Pro Gly Ala Gln Ala Val Val Gly Asp Leu Leu Glu Leu His 
                485                 490                 495     


Cys Glu Ser Leu Arg Gly Ser Phe Pro Ile Leu Tyr Trp Phe Tyr His 
            500                 505                 510         


Glu Asp Asp Thr Leu Gly Asn Ile Ser Ala His Ser Gly Gly Gly Ala 
        515                 520                 525             


Ser Phe Asn Leu Ser Leu Thr Thr Glu His Ser Gly Asn Tyr Ser Cys 
    530                 535                 540                 


Glu Ala Asp Asn Gly Leu Gly Ala Gln His Ser Lys Val Val Thr Leu 
545                 550                 555                 560 


Asn Val Thr Gly Thr Ser Arg Asn Arg Thr Gly Leu Thr Ala Ala Gly 
                565                 570                 575     


Ile Thr Gly Leu Val Leu Ser Ile Leu Val Leu Ala Ala Ala Ala Ala 
            580                 585                 590         


Leu Leu His Tyr Ala Arg Ala Arg Arg Lys Pro Gly Gly Leu Ser Ala 
        595                 600                 605             


Thr Gly Thr Ser Ser His Ser Pro Ser Glu Cys Gln Glu Pro Ser Ser 
    610                 615                 620                 


Ser Arg Pro Ser Arg Ile Asp Pro Gln Glu Pro Thr His Ser Lys Pro 
625                 630                 635                 640 


Leu Ala Pro Met Glu Leu Glu Pro Met Tyr Ser Asn Val Asn Pro Gly 
                645                 650                 655     


Asp Ser Asn Pro Ile Tyr Ser Gln Ile Trp Ser Ile Gln His Thr Lys 
            660                 665                 670         


Glu Asn Ser Ala Asn Cys Pro Met Met His Gln Glu His Glu Glu Leu 
        675                 680                 685             


Thr Val Leu Tyr Ser Glu Leu Lys Lys Thr His Pro Asp Asp Ser Ala 
    690                 695                 700                 


Gly Glu Ala Ser Ser Arg Gly Arg Ala His Glu Glu Asp Asp Glu Glu 
705                 710                 715                 720 


Asn Tyr Glu Asn Ile Leu Asn Pro Arg Lys Asn Lys Val Gln Asp Phe 
                725                 730                 735     


Pro Cys Leu Cys Asn Thr 
            740         


<210>  5232
<211>  734
<212>  PRT
<213>  Homo Sapiens

<400>  5232

Met Leu Leu Trp Leu Leu Leu Leu Ile Leu Thr Pro Gly Arg Glu Gln 
1               5                   10                  15      


Ser Gly Val Ala Pro Lys Ala Val Leu Leu Leu Asn Pro Pro Trp Ser 
            20                  25                  30          


Thr Ala Phe Lys Gly Glu Lys Val Ala Leu Ile Cys Ser Ser Ile Ser 
        35                  40                  45              


His Ser Leu Ala Gln Gly Asp Thr Tyr Trp Tyr His Asp Glu Lys Leu 
    50                  55                  60                  


Leu Lys Ile Lys His Asp Lys Ile Gln Ile Thr Glu Pro Gly Asn Tyr 
65                  70                  75                  80  


Gln Cys Lys Thr Arg Gly Ser Ser Leu Ser Asp Ala Val His Val Glu 
                85                  90                  95      


Phe Ser Pro Asp Trp Leu Ile Leu Gln Ala Leu His Pro Val Phe Glu 
            100                 105                 110         


Gly Asp Asn Val Ile Leu Arg Cys Gln Gly Lys Asp Asn Lys Asn Thr 
        115                 120                 125             


His Gln Lys Val Tyr Tyr Lys Asp Gly Lys Gln Leu Pro Asn Ser Tyr 
    130                 135                 140                 


Asn Leu Glu Lys Ile Thr Val Asn Ser Val Ser Arg Asp Asn Ser Lys 
145                 150                 155                 160 


Tyr His Cys Thr Ala Tyr Arg Lys Phe Tyr Ile Leu Asp Ile Glu Val 
                165                 170                 175     


Thr Ser Lys Pro Leu Asn Ile Gln Val Gln Glu Leu Phe Leu His Pro 
            180                 185                 190         


Val Leu Arg Ala Ser Ser Ser Thr Pro Ile Glu Gly Ser Pro Met Thr 
        195                 200                 205             


Leu Thr Cys Glu Thr Gln Leu Ser Pro Gln Arg Pro Asp Val Gln Leu 
    210                 215                 220                 


Gln Phe Ser Leu Phe Arg Asp Ser Gln Thr Leu Gly Leu Gly Trp Ser 
225                 230                 235                 240 


Arg Ser Pro Arg Leu Gln Ile Pro Ala Met Trp Thr Glu Asp Ser Gly 
                245                 250                 255     


Ser Tyr Trp Cys Glu Val Glu Thr Val Thr His Ser Ile Lys Lys Arg 
            260                 265                 270         


Ser Leu Arg Ser Gln Ile Arg Val Gln Arg Val Pro Val Ser Asn Val 
        275                 280                 285             


Asn Leu Glu Ile Arg Pro Thr Gly Gly Gln Leu Ile Glu Gly Glu Asn 
    290                 295                 300                 


Met Val Leu Ile Cys Ser Val Ala Gln Gly Ser Gly Thr Val Thr Phe 
305                 310                 315                 320 


Ser Trp His Lys Glu Gly Arg Val Arg Ser Leu Gly Arg Lys Thr Gln 
                325                 330                 335     


Arg Ser Leu Leu Ala Glu Leu His Val Leu Thr Val Lys Glu Ser Asp 
            340                 345                 350         


Ala Gly Arg Tyr Tyr Cys Ala Ala Asp Asn Val His Ser Pro Ile Leu 
        355                 360                 365             


Ser Thr Trp Ile Arg Val Thr Val Arg Ile Pro Val Ser His Pro Val 
    370                 375                 380                 


Leu Thr Phe Arg Ala Pro Arg Ala His Thr Val Val Gly Asp Leu Leu 
385                 390                 395                 400 


Glu Leu His Cys Glu Ser Leu Arg Gly Ser Pro Pro Ile Leu Tyr Arg 
                405                 410                 415     


Phe Tyr His Glu Asp Val Thr Leu Gly Asn Ser Ser Ala Pro Ser Gly 
            420                 425                 430         


Gly Gly Ala Ser Phe Asn Leu Ser Leu Thr Ala Glu His Ser Gly Asn 
        435                 440                 445             


Tyr Ser Cys Asp Ala Asp Asn Gly Leu Gly Ala Gln His Ser His Gly 
    450                 455                 460                 


Val Ser Leu Arg Val Thr Val Pro Val Ser Arg Pro Val Leu Thr Leu 
465                 470                 475                 480 


Arg Ala Pro Gly Ala Gln Ala Val Val Gly Asp Leu Leu Glu Leu His 
                485                 490                 495     


Cys Glu Ser Leu Arg Gly Ser Phe Pro Ile Leu Tyr Trp Phe Tyr His 
            500                 505                 510         


Glu Asp Asp Thr Leu Gly Asn Ile Ser Ala His Ser Gly Gly Gly Ala 
        515                 520                 525             


Ser Phe Asn Leu Ser Leu Thr Thr Glu His Ser Gly Asn Tyr Ser Cys 
    530                 535                 540                 


Glu Ala Asp Asn Gly Leu Gly Ala Gln His Ser Lys Val Val Thr Leu 
545                 550                 555                 560 


Asn Val Thr Gly Thr Ser Arg Asn Arg Thr Gly Leu Thr Ala Ala Gly 
                565                 570                 575     


Ile Thr Gly Leu Val Leu Ser Ile Leu Val Leu Ala Ala Ala Ala Ala 
            580                 585                 590         


Leu Leu His Tyr Ala Arg Ala Arg Arg Lys Pro Gly Gly Leu Ser Ala 
        595                 600                 605             


Thr Gly Thr Ser Ser His Ser Pro Ser Glu Cys Gln Glu Pro Ser Ser 
    610                 615                 620                 


Ser Arg Pro Ser Arg Ile Asp Pro Gln Glu Pro Thr His Ser Lys Pro 
625                 630                 635                 640 


Leu Ala Pro Met Glu Leu Glu Pro Met Tyr Ser Asn Val Asn Pro Gly 
                645                 650                 655     


Asp Ser Asn Pro Ile Tyr Ser Gln Ile Trp Ser Ile Gln His Thr Lys 
            660                 665                 670         


Glu Asn Ser Ala Asn Cys Pro Met Met His Gln Glu His Glu Glu Leu 
        675                 680                 685             


Thr Val Leu Tyr Ser Glu Leu Lys Lys Thr His Pro Asp Asp Ser Ala 
    690                 695                 700                 


Gly Glu Ala Ser Ser Arg Gly Arg Ala His Glu Glu Asp Asp Glu Glu 
705                 710                 715                 720 


Asn Tyr Glu Asn Val Pro Arg Val Leu Leu Ala Ser Asp His 
                725                 730                 


<210>  5233
<211>  256
<212>  PRT
<213>  Homo Sapiens

<400>  5233

Met Leu Leu Trp Leu Leu Leu Leu Ile Leu Thr Pro Gly Arg Glu Gln 
1               5                   10                  15      


Ser Gly Val Ala Pro Lys Ala Val Leu Leu Leu Asn Pro Pro Trp Ser 
            20                  25                  30          


Thr Ala Phe Lys Gly Glu Lys Val Ala Leu Ile Cys Ser Ser Ile Ser 
        35                  40                  45              


His Ser Leu Ala Gln Gly Asp Thr Tyr Trp Tyr His Asp Glu Lys Leu 
    50                  55                  60                  


Leu Lys Ile Lys His Asp Lys Ile Gln Ile Thr Glu Pro Gly Asn Tyr 
65                  70                  75                  80  


Gln Cys Lys Thr Arg Gly Ser Ser Leu Ser Asp Ala Val His Val Glu 
                85                  90                  95      


Phe Ser Pro Asp Trp Leu Ile Leu Gln Ala Leu His Pro Val Phe Glu 
            100                 105                 110         


Gly Asp Asn Val Ile Leu Arg Cys Gln Gly Lys Asp Asn Lys Asn Thr 
        115                 120                 125             


His Gln Lys Val Tyr Tyr Lys Asp Gly Lys Gln Leu Pro Asn Ser Tyr 
    130                 135                 140                 


Asn Leu Glu Lys Ile Thr Val Asn Ser Val Ser Arg Asp Asn Ser Lys 
145                 150                 155                 160 


Tyr His Cys Thr Ala Tyr Arg Lys Phe Tyr Ile Leu Asp Ile Glu Val 
                165                 170                 175     


Thr Ser Lys Pro Leu Asn Ile Gln Val Gln Glu Leu Phe Leu His Pro 
            180                 185                 190         


Val Leu Arg Ala Ser Ser Ser Thr Pro Ile Glu Gly Ser Pro Met Thr 
        195                 200                 205             


Leu Thr Cys Glu Thr Gln Leu Ser Pro Gln Arg Pro Asp Val Gln Leu 
    210                 215                 220                 


Gln Phe Ser Leu Phe Arg Asp Ser Gln Thr Leu Gly Leu Gly Trp Ser 
225                 230                 235                 240 


Arg Ser Pro Arg Leu Gln Ile Pro Ala Met Trp Thr Glu Asp Ser Gly 
                245                 250                 255     


<210>  5234
<211>  740
<212>  PRT
<213>  Homo Sapiens

<400>  5234

Met Leu Leu Trp Leu Leu Leu Leu Ile Leu Thr Pro Gly Arg Glu Gln 
1               5                   10                  15      


Ser Gly Val Ala Pro Lys Ala Val Leu Leu Leu Asn Pro Pro Trp Ser 
            20                  25                  30          


Thr Ala Phe Lys Gly Glu Lys Val Ala Leu Ile Cys Ser Ser Ile Ser 
        35                  40                  45              


His Ser Leu Ala Gln Gly Asp Thr Tyr Trp Tyr His Asp Glu Lys Leu 
    50                  55                  60                  


Leu Lys Ile Lys His Asp Lys Ile Gln Ile Thr Glu Pro Gly Asn Tyr 
65                  70                  75                  80  


Gln Cys Lys Thr Arg Gly Ser Ser Leu Ser Asp Ala Val His Val Glu 
                85                  90                  95      


Phe Ser Pro Asp Trp Leu Ile Leu Gln Ala Leu His Pro Val Phe Glu 
            100                 105                 110         


Gly Asp Asn Val Ile Leu Arg Cys Gln Gly Lys Asp Asn Lys Asn Thr 
        115                 120                 125             


His Gln Lys Val Tyr Tyr Lys Asp Gly Lys Gln Leu Pro Asn Ser Tyr 
    130                 135                 140                 


Asn Leu Glu Lys Ile Thr Val Asn Ser Val Ser Arg Asp Asn Ser Lys 
145                 150                 155                 160 


Tyr His Cys Thr Ala Tyr Arg Lys Phe Tyr Ile Leu Asp Ile Glu Val 
                165                 170                 175     


Thr Ser Lys Pro Leu Asn Ile Gln Val Gln Glu Leu Phe Leu His Pro 
            180                 185                 190         


Val Leu Arg Ala Ser Ser Ser Thr Pro Ile Glu Gly Ser Pro Met Thr 
        195                 200                 205             


Leu Thr Cys Glu Thr Gln Leu Ser Pro Gln Arg Pro Asp Val Gln Leu 
    210                 215                 220                 


Gln Phe Ser Leu Phe Arg Asp Ser Gln Thr Leu Gly Leu Gly Trp Ser 
225                 230                 235                 240 


Arg Ser Pro Arg Leu Gln Ile Pro Ala Met Trp Thr Glu Asp Ser Gly 
                245                 250                 255     


Ser Tyr Trp Cys Glu Val Glu Thr Val Thr His Ser Ile Lys Lys Arg 
            260                 265                 270         


Ser Leu Arg Ser Gln Ile Arg Val Gln Arg Val Pro Val Ser Asn Val 
        275                 280                 285             


Asn Leu Glu Ile Arg Pro Thr Gly Gly Gln Leu Ile Glu Gly Glu Asn 
    290                 295                 300                 


Met Val Leu Ile Cys Ser Val Ala Gln Gly Ser Gly Thr Val Thr Phe 
305                 310                 315                 320 


Ser Trp His Lys Glu Gly Arg Val Arg Ser Leu Gly Arg Lys Thr Gln 
                325                 330                 335     


Arg Ser Leu Leu Ala Glu Leu His Val Leu Thr Val Lys Glu Ser Asp 
            340                 345                 350         


Ala Gly Arg Tyr Tyr Cys Ala Ala Asp Asn Val His Ser Pro Ile Leu 
        355                 360                 365             


Ser Thr Trp Ile Arg Val Thr Val Arg Thr Leu Leu Ser Pro Ser Val 
    370                 375                 380                 


Pro Val Ser His Pro Val Leu Thr Phe Arg Ala Pro Arg Ala His Thr 
385                 390                 395                 400 


Val Val Gly Asp Leu Leu Glu Leu His Cys Glu Ser Leu Arg Gly Ser 
                405                 410                 415     


Pro Pro Ile Leu Tyr Arg Phe Tyr His Glu Asp Val Thr Leu Gly Asn 
            420                 425                 430         


Ser Ser Ala Pro Ser Gly Gly Gly Ala Ser Phe Asn Leu Ser Leu Thr 
        435                 440                 445             


Ala Glu His Ser Gly Asn Tyr Ser Cys Asp Ala Asp Asn Gly Leu Gly 
    450                 455                 460                 


Ala Gln His Ser His Gly Val Ser Leu Arg Val Thr Val Pro Val Ser 
465                 470                 475                 480 


Arg Pro Val Leu Thr Leu Arg Ala Pro Gly Ala Gln Ala Val Val Gly 
                485                 490                 495     


Asp Leu Leu Glu Leu His Cys Glu Ser Leu Arg Gly Ser Phe Pro Ile 
            500                 505                 510         


Leu Tyr Trp Phe Tyr His Glu Asp Asp Thr Leu Gly Asn Ile Ser Ala 
        515                 520                 525             


His Ser Gly Gly Gly Ala Ser Phe Asn Leu Ser Leu Thr Thr Glu His 
    530                 535                 540                 


Ser Gly Asn Tyr Ser Cys Glu Ala Asp Asn Gly Leu Gly Ala Gln His 
545                 550                 555                 560 


Ser Lys Val Val Thr Leu Asn Val Thr Gly Thr Ser Arg Asn Arg Thr 
                565                 570                 575     


Gly Leu Thr Ala Ala Gly Ile Thr Gly Leu Val Leu Ser Ile Leu Val 
            580                 585                 590         


Leu Ala Ala Ala Ala Ala Leu Leu His Tyr Ala Arg Ala Arg Arg Lys 
        595                 600                 605             


Pro Gly Gly Leu Ser Ala Thr Gly Thr Ser Ser His Ser Pro Ser Glu 
    610                 615                 620                 


Cys Gln Glu Pro Ser Ser Ser Arg Pro Ser Arg Ile Asp Pro Gln Glu 
625                 630                 635                 640 


Pro Thr His Ser Lys Pro Leu Ala Pro Met Glu Leu Glu Pro Met Tyr 
                645                 650                 655     


Ser Asn Val Asn Pro Gly Asp Ser Asn Pro Ile Tyr Ser Gln Ile Trp 
            660                 665                 670         


Ser Ile Gln His Thr Lys Glu Asn Ser Ala Asn Cys Pro Met Met His 
        675                 680                 685             


Gln Glu His Glu Glu Leu Thr Val Leu Tyr Ser Glu Leu Lys Lys Thr 
    690                 695                 700                 


His Pro Asp Asp Ser Ala Gly Glu Ala Ser Ser Arg Gly Arg Ala His 
705                 710                 715                 720 


Glu Glu Asp Asp Glu Glu Asn Tyr Glu Asn Val Pro Arg Val Leu Leu 
                725                 730                 735     


Ala Ser Asp His 
            740 


<210>  5235
<211>  734
<212>  PRT
<213>  Homo Sapiens

<400>  5235

Met Leu Leu Trp Leu Leu Leu Leu Ile Leu Thr Pro Gly Arg Glu Gln 
1               5                   10                  15      


Ser Gly Val Ala Pro Lys Ala Val Leu Leu Leu Asn Pro Pro Trp Ser 
            20                  25                  30          


Thr Ala Phe Lys Gly Glu Lys Val Ala Leu Ile Cys Ser Ser Ile Ser 
        35                  40                  45              


His Ser Leu Ala Gln Gly Asp Thr Tyr Trp Tyr His Asp Glu Lys Leu 
    50                  55                  60                  


Leu Lys Ile Lys His Asp Lys Ile Gln Ile Thr Glu Pro Gly Asn Tyr 
65                  70                  75                  80  


Gln Cys Lys Thr Arg Gly Ser Ser Leu Ser Asp Ala Val His Val Glu 
                85                  90                  95      


Phe Ser Pro Asp Trp Leu Ile Leu Gln Ala Leu His Pro Val Phe Glu 
            100                 105                 110         


Gly Asp Asn Val Ile Leu Arg Cys Gln Gly Lys Asp Asn Lys Asn Thr 
        115                 120                 125             


His Gln Lys Val Tyr Tyr Lys Asp Gly Lys Gln Leu Pro Asn Ser Tyr 
    130                 135                 140                 


Asn Leu Glu Lys Ile Thr Val Asn Ser Val Ser Arg Asp Asn Ser Lys 
145                 150                 155                 160 


Tyr His Cys Thr Ala Tyr Arg Lys Phe Tyr Ile Leu Asp Ile Glu Val 
                165                 170                 175     


Thr Ser Lys Pro Leu Asn Ile Gln Val Gln Glu Leu Phe Leu His Pro 
            180                 185                 190         


Val Leu Arg Ala Ser Ser Ser Thr Pro Ile Glu Gly Ser Pro Met Thr 
        195                 200                 205             


Leu Thr Cys Glu Thr Gln Leu Ser Pro Gln Arg Pro Asp Val Gln Leu 
    210                 215                 220                 


Gln Phe Ser Leu Phe Arg Asp Ser Gln Thr Leu Gly Leu Gly Trp Ser 
225                 230                 235                 240 


Arg Ser Pro Arg Leu Gln Ile Pro Ala Met Trp Thr Glu Asp Ser Gly 
                245                 250                 255     


Ser Tyr Trp Cys Glu Val Glu Thr Val Thr His Ser Ile Lys Lys Arg 
            260                 265                 270         


Ser Leu Arg Ser Gln Ile Arg Val Gln Arg Val Pro Val Ser Asn Val 
        275                 280                 285             


Asn Leu Glu Ile Arg Pro Thr Gly Gly Gln Leu Ile Glu Gly Glu Asn 
    290                 295                 300                 


Met Val Leu Ile Cys Ser Val Ala Gln Gly Ser Gly Thr Val Thr Phe 
305                 310                 315                 320 


Ser Trp His Lys Glu Gly Arg Val Arg Ser Leu Gly Arg Lys Thr Gln 
                325                 330                 335     


Arg Ser Leu Leu Ala Glu Leu His Val Leu Thr Val Lys Glu Ser Asp 
            340                 345                 350         


Ala Gly Arg Tyr Tyr Cys Ala Ala Asp Asn Val His Ser Pro Ile Leu 
        355                 360                 365             


Ser Thr Trp Ile Arg Val Thr Val Arg Ile Pro Val Ser His Pro Val 
    370                 375                 380                 


Leu Thr Phe Arg Ala Pro Arg Ala His Thr Val Val Gly Asp Leu Leu 
385                 390                 395                 400 


Glu Leu His Cys Glu Ser Leu Arg Gly Ser Pro Pro Ile Leu Tyr Arg 
                405                 410                 415     


Phe Tyr His Glu Asp Val Thr Leu Gly Asn Ser Ser Ala Pro Ser Gly 
            420                 425                 430         


Gly Gly Ala Ser Phe Asn Leu Ser Leu Thr Ala Glu His Ser Gly Asn 
        435                 440                 445             


Tyr Ser Cys Asp Ala Asp Asn Gly Leu Gly Ala Gln His Ser His Gly 
    450                 455                 460                 


Val Ser Leu Arg Val Thr Val Pro Val Ser Arg Pro Val Leu Thr Leu 
465                 470                 475                 480 


Arg Ala Pro Gly Ala Gln Ala Val Val Gly Asp Leu Leu Glu Leu His 
                485                 490                 495     


Cys Glu Ser Leu Arg Gly Ser Phe Pro Ile Leu Tyr Trp Phe Tyr His 
            500                 505                 510         


Glu Asp Asp Thr Leu Gly Asn Ile Ser Ala His Ser Gly Gly Gly Ala 
        515                 520                 525             


Ser Phe Asn Leu Ser Leu Thr Thr Glu His Ser Gly Asn Tyr Ser Cys 
    530                 535                 540                 


Glu Ala Asp Asn Gly Leu Gly Ala Gln His Ser Lys Val Val Thr Leu 
545                 550                 555                 560 


Asn Val Thr Gly Thr Ser Arg Asn Arg Thr Gly Leu Thr Ala Ala Gly 
                565                 570                 575     


Ile Thr Gly Leu Val Leu Ser Ile Leu Val Leu Ala Ala Ala Ala Ala 
            580                 585                 590         


Leu Leu His Tyr Ala Arg Ala Arg Arg Lys Pro Gly Gly Leu Ser Ala 
        595                 600                 605             


Thr Gly Thr Ser Ser His Ser Pro Ser Glu Cys Gln Glu Pro Ser Ser 
    610                 615                 620                 


Ser Arg Pro Ser Arg Ile Asp Pro Gln Glu Pro Thr His Ser Lys Pro 
625                 630                 635                 640 


Leu Ala Pro Met Glu Leu Glu Pro Met Tyr Ser Asn Val Asn Pro Gly 
                645                 650                 655     


Asp Ser Asn Pro Ile Tyr Ser Gln Ile Trp Ser Ile Gln His Thr Lys 
            660                 665                 670         


Glu Asn Ser Ala Asn Cys Pro Met Met His Gln Glu His Glu Glu Leu 
        675                 680                 685             


Thr Val Leu Tyr Ser Glu Leu Lys Lys Thr His Pro Asp Asp Ser Ala 
    690                 695                 700                 


Gly Glu Ala Ser Ser Arg Gly Arg Ala His Glu Glu Asp Asp Glu Glu 
705                 710                 715                 720 


Asn Tyr Glu Asn Val Pro Arg Val Leu Leu Ala Ser Asp His 
                725                 730                 


<210>  5236
<211>  639
<212>  PRT
<213>  Homo Sapiens

<400>  5236

Met Leu Leu Trp Leu Leu Leu Leu Ile Leu Thr Pro Gly Arg Glu Gln 
1               5                   10                  15      


Ser Gly Val Ala Pro Lys Ala Val Leu Leu Leu Asn Pro Pro Trp Ser 
            20                  25                  30          


Thr Ala Phe Lys Gly Glu Lys Val Ala Leu Ile Cys Ser Ser Ile Ser 
        35                  40                  45              


His Ser Leu Ala Gln Gly Asp Thr Tyr Trp Tyr His Asp Glu Lys Leu 
    50                  55                  60                  


Leu Lys Ile Lys His Asp Lys Ile Gln Ile Thr Glu Pro Gly Asn Tyr 
65                  70                  75                  80  


Gln Cys Lys Thr Arg Gly Ser Ser Leu Ser Asp Ala Val His Val Glu 
                85                  90                  95      


Phe Ser Pro Asp Trp Leu Ile Leu Gln Ala Leu His Pro Val Phe Glu 
            100                 105                 110         


Gly Asp Asn Val Ile Leu Arg Cys Gln Gly Lys Asp Asn Lys Asn Thr 
        115                 120                 125             


His Gln Lys Val Tyr Tyr Lys Asp Gly Lys Gln Leu Pro Asn Ser Tyr 
    130                 135                 140                 


Asn Leu Glu Lys Ile Thr Val Asn Ser Val Ser Arg Asp Asn Ser Lys 
145                 150                 155                 160 


Tyr His Cys Thr Ala Tyr Arg Lys Phe Tyr Ile Leu Asp Ile Glu Val 
                165                 170                 175     


Thr Ser Lys Pro Leu Asn Ile Gln Val Gln Gly Val Pro Val Ser Asn 
            180                 185                 190         


Val Asn Leu Glu Ile Arg Pro Thr Gly Gly Gln Leu Ile Glu Gly Glu 
        195                 200                 205             


Asn Met Val Leu Ile Cys Ser Val Ala Gln Gly Ser Gly Thr Val Thr 
    210                 215                 220                 


Phe Ser Trp His Lys Glu Gly Arg Val Arg Ser Leu Gly Arg Lys Thr 
225                 230                 235                 240 


Gln Arg Ser Leu Leu Ala Glu Leu His Val Leu Thr Val Lys Glu Ser 
                245                 250                 255     


Asp Ala Gly Arg Tyr Tyr Cys Ala Ala Asp Asn Val His Ser Pro Ile 
            260                 265                 270         


Leu Ser Thr Trp Ile Arg Val Thr Val Arg Ile Pro Val Ser His Pro 
        275                 280                 285             


Val Leu Thr Phe Arg Ala Pro Arg Ala His Thr Val Val Gly Asp Leu 
    290                 295                 300                 


Leu Glu Leu His Cys Glu Ser Leu Arg Gly Ser Pro Pro Ile Leu Tyr 
305                 310                 315                 320 


Arg Phe Tyr His Glu Asp Val Thr Leu Gly Asn Ser Ser Ala Pro Ser 
                325                 330                 335     


Gly Gly Gly Ala Ser Phe Asn Leu Ser Leu Thr Ala Glu His Ser Gly 
            340                 345                 350         


Asn Tyr Ser Cys Asp Ala Asp Asn Gly Leu Gly Ala Gln His Ser His 
        355                 360                 365             


Gly Val Ser Leu Arg Val Thr Val Pro Val Ser Arg Pro Val Leu Thr 
    370                 375                 380                 


Leu Arg Ala Pro Gly Ala Gln Ala Val Val Gly Asp Leu Leu Glu Leu 
385                 390                 395                 400 


His Cys Glu Ser Leu Arg Gly Ser Phe Pro Ile Leu Tyr Trp Phe Tyr 
                405                 410                 415     


His Glu Asp Asp Thr Leu Gly Asn Ile Ser Ala His Ser Gly Gly Gly 
            420                 425                 430         


Ala Ser Phe Asn Leu Ser Leu Thr Thr Glu His Ser Gly Asn Tyr Ser 
        435                 440                 445             


Cys Glu Ala Asp Asn Gly Leu Gly Ala Gln His Ser Lys Val Val Thr 
    450                 455                 460                 


Leu Asn Val Thr Gly Thr Ser Arg Asn Arg Thr Gly Leu Thr Ala Ala 
465                 470                 475                 480 


Gly Ile Thr Gly Leu Val Leu Ser Ile Leu Val Leu Ala Ala Ala Ala 
                485                 490                 495     


Ala Leu Leu His Tyr Ala Arg Ala Arg Arg Lys Pro Gly Gly Leu Ser 
            500                 505                 510         


Ala Thr Gly Thr Ser Ser His Ser Pro Ser Glu Cys Gln Glu Pro Ser 
        515                 520                 525             


Ser Ser Arg Pro Ser Arg Ile Asp Pro Gln Glu Pro Thr His Ser Lys 
    530                 535                 540                 


Pro Leu Ala Pro Met Glu Leu Glu Pro Met Tyr Ser Asn Val Asn Pro 
545                 550                 555                 560 


Gly Asp Ser Asn Pro Ile Tyr Ser Gln Ile Trp Ser Ile Gln His Thr 
                565                 570                 575     


Lys Glu Asn Ser Ala Asn Cys Pro Met Met His Gln Glu His Glu Glu 
            580                 585                 590         


Leu Thr Val Leu Tyr Ser Glu Leu Lys Lys Thr His Pro Asp Asp Ser 
        595                 600                 605             


Ala Gly Glu Ala Ser Ser Arg Gly Arg Ala His Glu Glu Asp Asp Glu 
    610                 615                 620                 


Glu Asn Tyr Glu Asn Val Pro Arg Val Leu Leu Ala Ser Asp His 
625                 630                 635                 


<210>  5237
<211>  592
<212>  PRT
<213>  Homo Sapiens

<400>  5237

Met Leu Leu Trp Val Ile Leu Leu Val Leu Ala Pro Val Ser Gly Gln 
1               5                   10                  15      


Phe Ala Arg Thr Pro Arg Pro Ile Ile Phe Leu Gln Pro Pro Trp Thr 
            20                  25                  30          


Thr Val Phe Gln Gly Glu Arg Val Thr Leu Thr Cys Lys Gly Phe Arg 
        35                  40                  45              


Phe Tyr Ser Pro Gln Lys Thr Lys Trp Tyr His Arg Tyr Leu Gly Lys 
    50                  55                  60                  


Glu Ile Leu Arg Glu Thr Pro Asp Asn Ile Leu Glu Val Gln Glu Ser 
65                  70                  75                  80  


Gly Glu Tyr Arg Cys Gln Ala Gln Gly Ser Pro Leu Ser Ser Pro Val 
                85                  90                  95      


His Leu Asp Phe Ser Ser Ala Ser Leu Ile Leu Gln Ala Pro Leu Ser 
            100                 105                 110         


Val Phe Glu Gly Asp Ser Val Val Leu Arg Cys Arg Ala Lys Ala Glu 
        115                 120                 125             


Val Thr Leu Asn Asn Thr Ile Tyr Lys Asn Asp Asn Val Leu Ala Phe 
    130                 135                 140                 


Leu Asn Lys Arg Thr Asp Phe His Ile Pro His Ala Cys Leu Lys Asp 
145                 150                 155                 160 


Asn Gly Ala Tyr Arg Cys Thr Gly Tyr Lys Glu Ser Cys Cys Pro Val 
                165                 170                 175     


Ser Ser Asn Thr Val Lys Ile Gln Val Gln Glu Pro Phe Thr Arg Pro 
            180                 185                 190         


Val Leu Arg Ala Ser Ser Phe Gln Pro Ile Ser Gly Asn Pro Val Thr 
        195                 200                 205             


Leu Thr Cys Glu Thr Gln Leu Ser Leu Glu Arg Ser Asp Val Pro Leu 
    210                 215                 220                 


Arg Phe Arg Phe Phe Arg Asp Asp Gln Thr Leu Gly Leu Gly Trp Ser 
225                 230                 235                 240 


Leu Ser Pro Asn Phe Gln Ile Thr Ala Met Trp Ser Lys Asp Ser Gly 
                245                 250                 255     


Phe Tyr Trp Cys Lys Ala Ala Thr Met Pro Tyr Ser Val Ile Ser Asp 
            260                 265                 270         


Ser Pro Arg Ser Trp Ile Gln Val Gln Ile Pro Ala Ser His Pro Val 
        275                 280                 285             


Leu Thr Leu Ser Pro Glu Lys Ala Leu Asn Phe Glu Gly Thr Lys Val 
    290                 295                 300                 


Thr Leu His Cys Glu Thr Gln Glu Asp Ser Leu Arg Thr Leu Tyr Arg 
305                 310                 315                 320 


Phe Tyr His Glu Gly Val Pro Leu Arg His Lys Ser Val Arg Cys Glu 
                325                 330                 335     


Arg Gly Ala Ser Ile Ser Phe Ser Leu Thr Thr Glu Asn Ser Gly Asn 
            340                 345                 350         


Tyr Tyr Cys Thr Ala Asp Asn Gly Leu Gly Ala Lys Pro Ser Lys Ala 
        355                 360                 365             


Val Ser Leu Ser Val Thr Val Pro Val Ser His Pro Val Leu Asn Leu 
    370                 375                 380                 


Ser Ser Pro Glu Asp Leu Ile Phe Glu Gly Ala Lys Val Thr Leu His 
385                 390                 395                 400 


Cys Glu Ala Gln Arg Gly Ser Leu Pro Ile Leu Tyr Gln Phe His His 
                405                 410                 415     


Glu Gly Ala Ala Leu Glu Arg Arg Ser Ala Asn Ser Ala Gly Gly Val 
            420                 425                 430         


Ala Ile Ser Phe Ser Leu Thr Ala Glu His Ser Gly Asn Tyr Tyr Cys 
        435                 440                 445             


Thr Ala Asp Asn Gly Phe Gly Pro Gln Arg Ser Lys Ala Val Ser Leu 
    450                 455                 460                 


Ser Val Thr Val Pro Val Ser His Pro Val Leu Thr Leu Ser Ser Ala 
465                 470                 475                 480 


Glu Ala Leu Thr Phe Glu Gly Ala Thr Val Thr Leu His Cys Glu Val 
                485                 490                 495     


Gln Arg Gly Ser Pro Gln Ile Leu Tyr Gln Phe Tyr His Glu Asp Met 
            500                 505                 510         


Pro Leu Trp Ser Ser Ser Thr Pro Ser Val Gly Arg Val Ser Phe Ser 
        515                 520                 525             


Phe Ser Leu Thr Glu Gly His Ser Gly Asn Tyr Tyr Cys Thr Ala Asp 
    530                 535                 540                 


Asn Gly Phe Gly Pro Gln Arg Ser Glu Val Val Ser Leu Phe Val Thr 
545                 550                 555                 560 


Gly Lys Cys Trp Val Leu Ala Ser His Pro Pro Leu Ala Glu Phe Ser 
                565                 570                 575     


Leu Thr His Ser Phe Lys Asn Leu Phe Ala Leu Ser Ser Phe Leu Pro 
            580                 585                 590         


<210>  5238
<211>  977
<212>  PRT
<213>  Homo Sapiens

<400>  5238

Met Leu Leu Trp Val Ile Leu Leu Val Leu Ala Pro Val Ser Gly Gln 
1               5                   10                  15      


Phe Ala Arg Thr Pro Arg Pro Ile Ile Phe Leu Gln Pro Pro Trp Thr 
            20                  25                  30          


Thr Val Phe Gln Gly Glu Arg Val Thr Leu Thr Cys Lys Gly Phe Arg 
        35                  40                  45              


Phe Tyr Ser Pro Gln Lys Thr Lys Trp Tyr His Arg Tyr Leu Gly Lys 
    50                  55                  60                  


Glu Ile Leu Arg Glu Thr Pro Asp Asn Ile Leu Glu Val Gln Glu Ser 
65                  70                  75                  80  


Gly Glu Tyr Arg Cys Gln Ala Gln Gly Ser Pro Leu Ser Ser Pro Val 
                85                  90                  95      


His Leu Asp Phe Ser Ser Ala Ser Leu Ile Leu Gln Ala Pro Leu Ser 
            100                 105                 110         


Val Phe Glu Gly Asp Ser Val Val Leu Arg Cys Arg Ala Lys Ala Glu 
        115                 120                 125             


Val Thr Leu Asn Asn Thr Ile Tyr Lys Asn Asp Asn Val Leu Ala Phe 
    130                 135                 140                 


Leu Asn Lys Arg Thr Asp Phe His Ile Pro His Ala Cys Leu Lys Asp 
145                 150                 155                 160 


Asn Gly Ala Tyr Arg Cys Thr Gly Tyr Lys Glu Ser Cys Cys Pro Val 
                165                 170                 175     


Ser Ser Asn Thr Val Lys Ile Gln Val Gln Glu Pro Phe Thr Arg Pro 
            180                 185                 190         


Val Leu Arg Ala Ser Ser Phe Gln Pro Ile Ser Gly Asn Pro Val Thr 
        195                 200                 205             


Leu Thr Cys Glu Thr Gln Leu Ser Leu Glu Arg Ser Asp Val Pro Leu 
    210                 215                 220                 


Arg Phe Arg Phe Phe Arg Asp Asp Gln Thr Leu Gly Leu Gly Trp Ser 
225                 230                 235                 240 


Leu Ser Pro Asn Phe Gln Ile Thr Ala Met Trp Ser Lys Asp Ser Gly 
                245                 250                 255     


Phe Tyr Trp Cys Lys Ala Ala Thr Met Pro Tyr Ser Val Ile Ser Asp 
            260                 265                 270         


Ser Pro Arg Ser Trp Ile Gln Val Gln Ile Pro Ala Ser His Pro Val 
        275                 280                 285             


Leu Thr Leu Ser Pro Glu Lys Ala Leu Asn Phe Glu Gly Thr Lys Val 
    290                 295                 300                 


Thr Leu His Cys Glu Thr Gln Glu Asp Ser Leu Arg Thr Leu Tyr Arg 
305                 310                 315                 320 


Phe Tyr His Glu Gly Val Pro Leu Arg His Lys Ser Val Arg Cys Glu 
                325                 330                 335     


Arg Gly Ala Ser Ile Ser Phe Ser Leu Thr Thr Glu Asn Ser Gly Asn 
            340                 345                 350         


Tyr Tyr Cys Thr Ala Asp Asn Gly Leu Gly Ala Lys Pro Ser Lys Ala 
        355                 360                 365             


Val Ser Leu Ser Val Thr Val Pro Val Ser His Pro Val Leu Asn Leu 
    370                 375                 380                 


Ser Ser Pro Glu Asp Leu Ile Phe Glu Gly Ala Lys Val Thr Leu His 
385                 390                 395                 400 


Cys Glu Ala Gln Arg Gly Ser Leu Pro Ile Leu Tyr Gln Phe His His 
                405                 410                 415     


Glu Gly Ala Ala Leu Glu Arg Arg Ser Ala Asn Ser Ala Gly Gly Val 
            420                 425                 430         


Ala Ile Ser Phe Ser Leu Thr Ala Glu His Ser Gly Asn Tyr Tyr Cys 
        435                 440                 445             


Thr Ala Asp Asn Gly Phe Gly Pro Gln Arg Ser Lys Ala Val Ser Leu 
    450                 455                 460                 


Ser Val Thr Val Pro Val Ser His Pro Val Leu Thr Leu Ser Ser Ala 
465                 470                 475                 480 


Glu Ala Leu Thr Phe Glu Gly Ala Thr Val Thr Leu His Cys Glu Val 
                485                 490                 495     


Gln Arg Gly Ser Pro Gln Ile Leu Tyr Gln Phe Tyr His Glu Asp Met 
            500                 505                 510         


Pro Leu Trp Ser Ser Ser Thr Pro Ser Val Gly Arg Val Ser Phe Ser 
        515                 520                 525             


Phe Ser Leu Thr Glu Gly His Ser Gly Asn Tyr Tyr Cys Thr Ala Asp 
    530                 535                 540                 


Asn Gly Phe Gly Pro Gln Arg Ser Glu Val Val Ser Leu Phe Val Thr 
545                 550                 555                 560 


Val Pro Val Ser Arg Pro Ile Leu Thr Leu Arg Val Pro Arg Ala Gln 
                565                 570                 575     


Ala Val Val Gly Asp Leu Leu Glu Leu His Cys Glu Ala Pro Arg Gly 
            580                 585                 590         


Ser Pro Pro Ile Leu Tyr Trp Phe Tyr His Glu Asp Val Thr Leu Gly 
        595                 600                 605             


Ser Ser Ser Ala Pro Ser Gly Gly Glu Ala Ser Phe Asn Leu Ser Leu 
    610                 615                 620                 


Thr Ala Glu His Ser Gly Asn Tyr Ser Cys Glu Ala Asn Asn Gly Leu 
625                 630                 635                 640 


Val Ala Gln His Ser Asp Thr Ile Ser Leu Ser Val Ile Val Pro Val 
                645                 650                 655     


Ser Arg Pro Ile Leu Thr Phe Arg Ala Pro Arg Ala Gln Ala Val Val 
            660                 665                 670         


Gly Asp Leu Leu Glu Leu His Cys Glu Ala Leu Arg Gly Ser Ser Pro 
        675                 680                 685             


Ile Leu Tyr Trp Phe Tyr His Glu Asp Val Thr Leu Gly Lys Ile Ser 
    690                 695                 700                 


Ala Pro Ser Gly Gly Gly Ala Ser Phe Asn Leu Ser Leu Thr Thr Glu 
705                 710                 715                 720 


His Ser Gly Ile Tyr Ser Cys Glu Ala Asp Asn Gly Leu Glu Ala Gln 
                725                 730                 735     


Arg Ser Glu Met Val Thr Leu Lys Val Ala Val Pro Val Ser Arg Pro 
            740                 745                 750         


Val Leu Thr Leu Arg Ala Pro Gly Thr His Ala Ala Val Gly Asp Leu 
        755                 760                 765             


Leu Glu Leu His Cys Glu Ala Leu Arg Gly Ser Pro Leu Ile Leu Tyr 
    770                 775                 780                 


Arg Phe Phe His Glu Asp Val Thr Leu Gly Asn Arg Ser Ser Pro Ser 
785                 790                 795                 800 


Gly Gly Ala Ser Leu Asn Leu Ser Leu Thr Ala Glu His Ser Gly Asn 
                805                 810                 815     


Tyr Ser Cys Glu Ala Asp Asn Gly Leu Gly Ala Gln Arg Ser Glu Thr 
            820                 825                 830         


Val Thr Leu Tyr Ile Thr Gly Leu Thr Ala Asn Arg Ser Gly Pro Phe 
        835                 840                 845             


Ala Thr Gly Val Ala Gly Gly Leu Leu Ser Ile Ala Gly Leu Ala Ala 
    850                 855                 860                 


Gly Ala Leu Leu Leu Tyr Cys Trp Leu Ser Arg Lys Ala Gly Arg Lys 
865                 870                 875                 880 


Pro Ala Ser Asp Pro Ala Arg Ser Pro Ser Asp Ser Asp Ser Gln Glu 
                885                 890                 895     


Pro Thr Tyr His Asn Val Pro Ala Trp Glu Glu Leu Gln Pro Val Tyr 
            900                 905                 910         


Thr Asn Ala Asn Pro Arg Gly Glu Asn Val Val Tyr Ser Glu Val Arg 
        915                 920                 925             


Ile Ile Gln Glu Lys Lys Lys His Ala Val Ala Ser Asp Pro Arg His 
    930                 935                 940                 


Leu Arg Asn Lys Gly Ser Pro Ile Ile Tyr Ser Glu Val Lys Val Ala 
945                 950                 955                 960 


Ser Thr Pro Val Ser Gly Ser Leu Phe Leu Ala Ser Ser Ala Pro His 
                965                 970                 975     


Arg 
    


<210>  5239
<211>  759
<212>  PRT
<213>  Homo Sapiens

<400>  5239

Met Leu Leu Trp Val Ile Leu Leu Val Leu Ala Pro Val Ser Gly Gln 
1               5                   10                  15      


Phe Ala Arg Thr Pro Arg Pro Ile Ile Phe Leu Gln Pro Pro Trp Thr 
            20                  25                  30          


Thr Val Phe Gln Gly Glu Arg Val Thr Leu Thr Cys Lys Gly Phe Arg 
        35                  40                  45              


Phe Tyr Ser Pro Gln Lys Thr Lys Trp Tyr His Arg Tyr Leu Gly Lys 
    50                  55                  60                  


Glu Ile Leu Arg Glu Thr Pro Asp Asn Ile Leu Glu Val Gln Glu Ser 
65                  70                  75                  80  


Gly Glu Tyr Arg Cys Gln Ala Gln Gly Ser Pro Leu Ser Ser Pro Val 
                85                  90                  95      


His Leu Asp Phe Ser Ser Ala Ser Leu Ile Leu Gln Ala Pro Leu Ser 
            100                 105                 110         


Val Phe Glu Gly Asp Ser Val Val Leu Arg Cys Arg Ala Lys Ala Glu 
        115                 120                 125             


Val Thr Leu Asn Asn Thr Ile Tyr Lys Asn Asp Asn Val Leu Ala Phe 
    130                 135                 140                 


Leu Asn Lys Arg Thr Asp Phe His Ile Pro His Ala Cys Leu Lys Asp 
145                 150                 155                 160 


Asn Gly Ala Tyr Arg Cys Thr Gly Tyr Lys Glu Ser Cys Cys Pro Val 
                165                 170                 175     


Ser Ser Asn Thr Val Lys Ile Gln Val Gln Glu Pro Phe Thr Arg Pro 
            180                 185                 190         


Val Leu Arg Ala Ser Ser Phe Gln Pro Ile Ser Gly Asn Pro Val Thr 
        195                 200                 205             


Leu Thr Cys Glu Thr Gln Leu Ser Leu Glu Arg Ser Asp Val Pro Leu 
    210                 215                 220                 


Arg Phe Arg Phe Phe Arg Asp Asp Gln Thr Leu Gly Leu Gly Trp Ser 
225                 230                 235                 240 


Leu Ser Pro Asn Phe Gln Ile Thr Ala Met Trp Ser Lys Asp Ser Gly 
                245                 250                 255     


Phe Tyr Trp Cys Lys Ala Ala Thr Met Pro Tyr Ser Val Ile Ser Asp 
            260                 265                 270         


Ser Pro Arg Ser Trp Ile Gln Val Gln Ile Pro Ala Ser His Pro Val 
        275                 280                 285             


Leu Thr Leu Ser Pro Glu Lys Ala Leu Asn Phe Glu Gly Thr Lys Val 
    290                 295                 300                 


Thr Leu His Cys Glu Thr Gln Glu Asp Ser Leu Arg Thr Leu Tyr Arg 
305                 310                 315                 320 


Phe Tyr His Glu Gly Val Pro Leu Arg His Lys Ser Val Arg Cys Glu 
                325                 330                 335     


Arg Gly Ala Ser Ile Ser Phe Ser Leu Thr Thr Glu Asn Ser Gly Asn 
            340                 345                 350         


Tyr Tyr Cys Thr Ala Asp Asn Gly Leu Gly Ala Lys Pro Ser Lys Ala 
        355                 360                 365             


Val Ser Leu Ser Val Thr Val Pro Val Ser His Pro Val Leu Asn Leu 
    370                 375                 380                 


Ser Ser Pro Glu Asp Leu Ile Phe Glu Gly Ala Lys Val Thr Leu His 
385                 390                 395                 400 


Cys Glu Ala Gln Arg Gly Ser Leu Pro Ile Leu Tyr Gln Phe His His 
                405                 410                 415     


Glu Gly Ala Ala Leu Glu Arg Arg Ser Ala Asn Ser Ala Gly Gly Val 
            420                 425                 430         


Ala Ile Ser Phe Ser Leu Thr Ala Glu His Ser Gly Asn Tyr Tyr Cys 
        435                 440                 445             


Thr Ala Asp Asn Gly Phe Gly Pro Gln Arg Ser Lys Ala Val Ser Leu 
    450                 455                 460                 


Ser Val Thr Val Pro Val Ser His Pro Val Leu Thr Leu Ser Ser Ala 
465                 470                 475                 480 


Glu Ala Leu Thr Phe Glu Gly Ala Thr Val Thr Leu His Cys Glu Val 
                485                 490                 495     


Gln Arg Gly Ser Pro Gln Ile Leu Tyr Gln Phe Tyr His Glu Asp Met 
            500                 505                 510         


Pro Leu Trp Ser Ser Ser Thr Pro Ser Val Gly Arg Val Ser Phe Ser 
        515                 520                 525             


Phe Ser Leu Thr Glu Gly His Ser Gly Asn Tyr Tyr Cys Thr Ala Asp 
    530                 535                 540                 


Asn Gly Phe Gly Pro Gln Arg Ser Glu Val Val Ser Leu Phe Val Thr 
545                 550                 555                 560 


Val Pro Val Ser Arg Pro Ile Leu Thr Leu Arg Val Pro Arg Ala Gln 
                565                 570                 575     


Ala Val Val Gly Asp Leu Leu Glu Leu His Cys Glu Ala Pro Arg Gly 
            580                 585                 590         


Ser Pro Pro Ile Leu Tyr Trp Phe Tyr His Glu Asp Val Thr Leu Gly 
        595                 600                 605             


Ser Ser Ser Ala Pro Ser Gly Gly Glu Ala Ser Phe Asn Leu Ser Leu 
    610                 615                 620                 


Thr Ala Glu His Ser Gly Asn Tyr Ser Cys Glu Ala Asn Asn Gly Leu 
625                 630                 635                 640 


Val Ala Gln His Ser Asp Thr Ile Ser Leu Ser Val Ile Val Pro Val 
                645                 650                 655     


Ser Arg Pro Ile Leu Thr Phe Arg Ala Pro Arg Ala Gln Ala Val Val 
            660                 665                 670         


Gly Asp Leu Leu Glu Leu His Cys Glu Ala Leu Arg Gly Ser Ser Pro 
        675                 680                 685             


Ile Leu Tyr Trp Phe Tyr His Glu Asp Val Thr Leu Gly Lys Ile Ser 
    690                 695                 700                 


Ala Pro Ser Gly Gly Gly Ala Ser Phe Asn Leu Ser Leu Thr Thr Glu 
705                 710                 715                 720 


His Ser Gly Ile Tyr Ser Cys Glu Ala Asp Asn Gly Leu Glu Ala Gln 
                725                 730                 735     


Arg Ser Glu Met Val Thr Leu Lys Val Ala Gly Glu Trp Ala Leu Pro 
            740                 745                 750         


Thr Ser Ser Thr Ser Glu Asn 
        755                 


<210>  5240
<211>  365
<212>  PRT
<213>  Homo Sapiens

<400>  5240

Met Lys Leu Gly Cys Val Leu Met Ala Trp Ala Leu Tyr Leu Ser Leu 
1               5                   10                  15      


Gly Val Leu Trp Val Ala Gln Met Leu Leu Ala Ala Gly Cys His Ala 
            20                  25                  30          


Ala Ala Ser Phe Glu Thr Leu Gln Cys Glu Gly Pro Val Cys Thr Glu 
        35                  40                  45              


Glu Ser Ser Cys His Thr Glu Asp Asp Leu Thr Asp Ala Arg Glu Ala 
    50                  55                  60                  


Gly Phe Gln Val Lys Ala Tyr Thr Phe Ser Glu Pro Phe His Leu Ile 
65                  70                  75                  80  


Val Ser Tyr Asp Trp Leu Ile Leu Gln Gly Pro Ala Lys Pro Val Phe 
                85                  90                  95      


Glu Gly Asp Leu Leu Val Leu Arg Cys Gln Ala Trp Gln Asp Trp Pro 
            100                 105                 110         


Leu Thr Gln Val Thr Phe Tyr Arg Asp Gly Ser Ala Leu Gly Pro Pro 
        115                 120                 125             


Gly Pro Asn Arg Glu Phe Ser Ile Thr Val Val Gln Lys Ala Asp Ser 
    130                 135                 140                 


Gly His Tyr His Cys Ser Gly Ile Phe Gln Ser Pro Gly Pro Gly Ile 
145                 150                 155                 160 


Pro Glu Thr Ala Ser Val Val Ala Ile Thr Val Gln Glu Leu Phe Pro 
                165                 170                 175     


Ala Pro Ile Leu Arg Ala Val Pro Ser Ala Glu Pro Gln Ala Gly Ser 
            180                 185                 190         


Pro Met Thr Leu Ser Cys Gln Thr Lys Leu Pro Leu Gln Arg Ser Ala 
        195                 200                 205             


Ala Arg Leu Leu Phe Ser Phe Tyr Lys Asp Gly Arg Ile Val Gln Ser 
    210                 215                 220                 


Arg Gly Leu Ser Ser Glu Phe Gln Ile Pro Thr Ala Ser Glu Asp His 
225                 230                 235                 240 


Ser Gly Ser Tyr Trp Cys Glu Ala Ala Thr Glu Asp Asn Gln Val Trp 
                245                 250                 255     


Lys Gln Ser Pro Gln Leu Glu Ile Arg Val Gln Gly Ala Ser Ser Ser 
            260                 265                 270         


Ala Ala Pro Pro Thr Leu Asn Pro Ala Pro Gln Lys Ser Ala Ala Pro 
        275                 280                 285             


Gly Thr Ala Pro Glu Glu Ala Pro Gly Pro Leu Pro Pro Pro Pro Thr 
    290                 295                 300                 


Pro Ser Ser Glu Asp Pro Gly Phe Ser Ser Pro Leu Gly Met Pro Asp 
305                 310                 315                 320 


Pro His Leu Tyr His Gln Met Gly Leu Leu Leu Lys His Met Gln Asp 
                325                 330                 335     


Val Arg Val Leu Leu Gly His Leu Leu Met Glu Leu Arg Glu Leu Ser 
            340                 345                 350         


Gly His Arg Lys Pro Gly Thr Thr Lys Ala Thr Ala Glu 
        355                 360                 365 


<210>  5241
<211>  225
<212>  PRT
<213>  Homo Sapiens

<400>  5241

Met Lys Leu Gly Cys Val Leu Met Ala Trp Ala Leu Tyr Leu Ser Leu 
1               5                   10                  15      


Gly Val Leu Trp Val Ala Gln Met Leu Leu Ala Ala Gly Cys His Ala 
            20                  25                  30          


Glu Leu Phe Pro Ala Pro Ile Leu Arg Ala Val Pro Ser Ala Glu Pro 
        35                  40                  45              


Gln Ala Gly Ser Pro Met Thr Leu Ser Cys Gln Thr Lys Leu Pro Leu 
    50                  55                  60                  


Gln Arg Ser Ala Ala Arg Leu Leu Phe Ser Phe Tyr Lys Asp Gly Arg 
65                  70                  75                  80  


Ile Val Gln Ser Arg Gly Leu Ser Ser Glu Phe Gln Ile Pro Thr Ala 
                85                  90                  95      


Ser Glu Asp His Ser Gly Ser Tyr Trp Cys Glu Ala Ala Thr Glu Asp 
            100                 105                 110         


Asn Gln Val Trp Lys Gln Ser Pro Gln Leu Glu Ile Arg Val Gln Gly 
        115                 120                 125             


Ala Ser Ser Ser Ala Ala Pro Pro Thr Leu Asn Pro Ala Pro Gln Lys 
    130                 135                 140                 


Ser Ala Ala Pro Gly Thr Ala Pro Glu Glu Ala Pro Gly Pro Leu Pro 
145                 150                 155                 160 


Pro Pro Pro Thr Pro Ser Ser Glu Asp Pro Gly Phe Ser Ser Pro Leu 
                165                 170                 175     


Gly Met Pro Asp Pro His Leu Tyr His Gln Met Gly Leu Leu Leu Lys 
            180                 185                 190         


His Met Gln Asp Val Arg Val Leu Leu Gly His Leu Leu Met Glu Leu 
        195                 200                 205             


Arg Glu Leu Ser Gly His Arg Lys Pro Gly Thr Thr Lys Ala Thr Ala 
    210                 215                 220                 


Glu 
225 


<210>  5242
<211>  264
<212>  PRT
<213>  Homo Sapiens

<400>  5242

Met Lys Leu Gly Cys Val Leu Met Ala Trp Ala Leu Tyr Leu Ser Leu 
1               5                   10                  15      


Gly Val Leu Trp Val Ala Gln Met Leu Leu Ala Ala Ser Phe Glu Thr 
            20                  25                  30          


Leu Gln Cys Glu Gly Pro Val Cys Thr Glu Glu Ser Ser Cys His Thr 
        35                  40                  45              


Glu Asp Asp Leu Thr Asp Ala Arg Glu Ala Gly Phe Gln Val Lys Ala 
    50                  55                  60                  


Tyr Thr Phe Ser Glu Pro Phe His Leu Ile Val Ser Tyr Asp Trp Leu 
65                  70                  75                  80  


Ile Leu Gln Gly Pro Ala Lys Pro Val Phe Glu Gly Asp Leu Leu Val 
                85                  90                  95      


Leu Arg Cys Gln Ala Trp Gln Asp Trp Pro Leu Thr Gln Val Thr Phe 
            100                 105                 110         


Tyr Arg Asp Gly Ser Ala Leu Gly Pro Pro Gly Pro Asn Arg Glu Phe 
        115                 120                 125             


Ser Ile Thr Val Val Gln Lys Ala Asp Ser Gly His Tyr His Cys Ser 
    130                 135                 140                 


Gly Ile Phe Gln Ser Pro Gly Pro Gly Ile Pro Glu Thr Ala Ser Val 
145                 150                 155                 160 


Val Ala Ile Thr Val Gln Gly Ala Ser Ser Ser Ala Ala Pro Pro Thr 
                165                 170                 175     


Leu Asn Pro Ala Pro Gln Lys Ser Ala Ala Pro Gly Thr Ala Pro Glu 
            180                 185                 190         


Glu Ala Pro Gly Pro Leu Pro Pro Pro Pro Thr Pro Ser Ser Glu Asp 
        195                 200                 205             


Pro Gly Phe Ser Ser Pro Leu Gly Met Pro Asp Pro His Leu Tyr His 
    210                 215                 220                 


Gln Met Gly Leu Leu Leu Lys His Met Gln Asp Val Arg Val Leu Leu 
225                 230                 235                 240 


Gly His Leu Leu Met Glu Leu Arg Glu Leu Ser Gly His Arg Lys Pro 
                245                 250                 255     


Gly Thr Thr Lys Ala Thr Ala Glu 
            260                 


<210>  5243
<211>  270
<212>  PRT
<213>  Homo Sapiens

<400>  5243

Met Lys Leu Gly Cys Val Leu Met Ala Trp Ala Leu Tyr Leu Ser Leu 
1               5                   10                  15      


Gly Val Leu Trp Val Ala Gln Met Leu Leu Ala Ala Ser Phe Glu Thr 
            20                  25                  30          


Leu Gln Cys Glu Gly Pro Val Cys Thr Glu Glu Ser Ser Cys His Thr 
        35                  40                  45              


Glu Asp Asp Leu Thr Asp Ala Arg Glu Ala Gly Phe Gln Val Lys Ala 
    50                  55                  60                  


Tyr Thr Phe Ser Glu Pro Phe His Leu Ile Val Ser Tyr Glu Leu Phe 
65                  70                  75                  80  


Pro Ala Pro Ile Leu Arg Ala Val Pro Ser Ala Glu Pro Gln Ala Gly 
                85                  90                  95      


Ser Pro Met Thr Leu Ser Cys Gln Thr Lys Leu Pro Leu Gln Arg Ser 
            100                 105                 110         


Ala Ala Arg Leu Leu Phe Ser Phe Tyr Lys Asp Gly Arg Ile Val Gln 
        115                 120                 125             


Ser Arg Gly Leu Ser Ser Glu Phe Gln Ile Pro Thr Ala Ser Glu Asp 
    130                 135                 140                 


His Ser Gly Ser Tyr Trp Cys Glu Ala Ala Thr Glu Asp Asn Gln Val 
145                 150                 155                 160 


Trp Lys Gln Ser Pro Gln Leu Glu Ile Arg Val Gln Gly Ala Ser Ser 
                165                 170                 175     


Ser Ala Ala Pro Pro Thr Leu Asn Pro Ala Pro Gln Lys Ser Ala Ala 
            180                 185                 190         


Pro Gly Thr Ala Pro Glu Glu Ala Pro Gly Pro Leu Pro Pro Pro Pro 
        195                 200                 205             


Thr Pro Ser Ser Glu Asp Pro Gly Phe Ser Ser Pro Leu Gly Met Pro 
    210                 215                 220                 


Asp Pro His Leu Tyr His Gln Met Gly Leu Leu Leu Lys His Met Gln 
225                 230                 235                 240 


Asp Val Arg Val Leu Leu Gly His Leu Leu Met Glu Leu Arg Glu Leu 
                245                 250                 255     


Ser Gly His Arg Lys Pro Gly Thr Thr Lys Ala Thr Ala Glu 
            260                 265                 270 


<210>  5244
<211>  382
<212>  PRT
<213>  Homo Sapiens

<400>  5244

Met Leu Lys Lys Ile Ser Val Gly Val Ala Gly Asp Leu Asn Thr Val 
1               5                   10                  15      


Thr Met Lys Leu Gly Cys Val Leu Met Ala Trp Ala Leu Tyr Leu Ser 
            20                  25                  30          


Leu Gly Val Leu Trp Val Ala Gln Met Leu Leu Ala Ala Gly Cys His 
        35                  40                  45              


Ala Ala Ala Ser Phe Glu Thr Leu Gln Cys Glu Gly Pro Val Cys Thr 
    50                  55                  60                  


Glu Glu Ser Ser Cys His Thr Glu Asp Asp Leu Thr Asp Ala Arg Glu 
65                  70                  75                  80  


Ala Gly Phe Gln Val Lys Ala Tyr Thr Phe Ser Glu Pro Phe His Leu 
                85                  90                  95      


Ile Val Ser Tyr Asp Trp Leu Ile Leu Gln Gly Pro Ala Lys Pro Val 
            100                 105                 110         


Phe Glu Gly Asp Leu Leu Val Leu Arg Cys Gln Ala Trp Gln Asp Trp 
        115                 120                 125             


Pro Leu Thr Gln Val Thr Phe Tyr Arg Asp Gly Ser Ala Leu Gly Pro 
    130                 135                 140                 


Pro Gly Pro Asn Arg Glu Phe Ser Ile Thr Val Val Gln Lys Ala Asp 
145                 150                 155                 160 


Ser Gly His Tyr His Cys Ser Gly Ile Phe Gln Ser Pro Gly Pro Gly 
                165                 170                 175     


Ile Pro Glu Thr Ala Ser Val Val Ala Ile Thr Val Gln Glu Leu Phe 
            180                 185                 190         


Pro Ala Pro Ile Leu Arg Ala Val Pro Ser Ala Glu Pro Gln Ala Gly 
        195                 200                 205             


Ser Pro Met Thr Leu Ser Cys Gln Thr Lys Leu Pro Leu Gln Arg Ser 
    210                 215                 220                 


Ala Ala Arg Leu Leu Phe Ser Phe Tyr Lys Asp Gly Arg Ile Val Gln 
225                 230                 235                 240 


Ser Arg Gly Leu Ser Ser Glu Phe Gln Ile Pro Thr Ala Ser Glu Asp 
                245                 250                 255     


His Ser Gly Ser Tyr Trp Cys Glu Ala Ala Thr Glu Asp Asn Gln Val 
            260                 265                 270         


Trp Lys Gln Ser Pro Gln Leu Glu Ile Arg Val Gln Gly Ala Ser Ser 
        275                 280                 285             


Ser Ala Ala Pro Pro Thr Leu Asn Pro Ala Pro Gln Lys Ser Ala Ala 
    290                 295                 300                 


Pro Gly Thr Ala Pro Glu Glu Ala Pro Gly Pro Leu Pro Pro Pro Pro 
305                 310                 315                 320 


Thr Pro Ser Ser Glu Asp Pro Gly Phe Ser Ser Pro Leu Gly Met Pro 
                325                 330                 335     


Asp Pro His Leu Tyr His Gln Met Gly Leu Leu Leu Lys His Met Gln 
            340                 345                 350         


Asp Val Arg Val Leu Leu Gly His Leu Leu Met Glu Leu Arg Glu Leu 
        355                 360                 365             


Ser Gly His Arg Lys Pro Gly Thr Thr Lys Ala Thr Ala Glu 
    370                 375                 380         


<210>  5245
<211>  242
<212>  PRT
<213>  Homo Sapiens

<400>  5245

Met Leu Lys Lys Ile Ser Val Gly Val Ala Gly Asp Leu Asn Thr Val 
1               5                   10                  15      


Thr Met Lys Leu Gly Cys Val Leu Met Ala Trp Ala Leu Tyr Leu Ser 
            20                  25                  30          


Leu Gly Val Leu Trp Val Ala Gln Met Leu Leu Ala Ala Gly Cys His 
        35                  40                  45              


Ala Glu Leu Phe Pro Ala Pro Ile Leu Arg Ala Val Pro Ser Ala Glu 
    50                  55                  60                  


Pro Gln Ala Gly Ser Pro Met Thr Leu Ser Cys Gln Thr Lys Leu Pro 
65                  70                  75                  80  


Leu Gln Arg Ser Ala Ala Arg Leu Leu Phe Ser Phe Tyr Lys Asp Gly 
                85                  90                  95      


Arg Ile Val Gln Ser Arg Gly Leu Ser Ser Glu Phe Gln Ile Pro Thr 
            100                 105                 110         


Ala Ser Glu Asp His Ser Gly Ser Tyr Trp Cys Glu Ala Ala Thr Glu 
        115                 120                 125             


Asp Asn Gln Val Trp Lys Gln Ser Pro Gln Leu Glu Ile Arg Val Gln 
    130                 135                 140                 


Gly Ala Ser Ser Ser Ala Ala Pro Pro Thr Leu Asn Pro Ala Pro Gln 
145                 150                 155                 160 


Lys Ser Ala Ala Pro Gly Thr Ala Pro Glu Glu Ala Pro Gly Pro Leu 
                165                 170                 175     


Pro Pro Pro Pro Thr Pro Ser Ser Glu Asp Pro Gly Phe Ser Ser Pro 
            180                 185                 190         


Leu Gly Met Pro Asp Pro His Leu Tyr His Gln Met Gly Leu Leu Leu 
        195                 200                 205             


Lys His Met Gln Asp Val Arg Val Leu Leu Gly His Leu Leu Met Glu 
    210                 215                 220                 


Leu Arg Glu Leu Ser Gly His Arg Lys Pro Gly Thr Thr Lys Ala Thr 
225                 230                 235                 240 


Ala Glu 
        


<210>  5246
<211>  376
<212>  PRT
<213>  Homo Sapiens

<400>  5246

Met Leu Lys Lys Ile Ser Val Gly Val Ala Gly Asp Leu Asn Thr Val 
1               5                   10                  15      


Thr Met Lys Leu Gly Cys Val Leu Met Ala Trp Ala Leu Tyr Leu Ser 
            20                  25                  30          


Leu Gly Val Leu Trp Val Ala Gln Met Leu Leu Ala Ala Ser Phe Glu 
        35                  40                  45              


Thr Leu Gln Cys Glu Gly Pro Val Cys Thr Glu Glu Ser Ser Cys His 
    50                  55                  60                  


Thr Glu Asp Asp Leu Thr Asp Ala Arg Glu Ala Gly Phe Gln Val Lys 
65                  70                  75                  80  


Ala Tyr Thr Phe Ser Glu Pro Phe His Leu Ile Val Ser Tyr Asp Trp 
                85                  90                  95      


Leu Ile Leu Gln Gly Pro Ala Lys Pro Val Phe Glu Gly Asp Leu Leu 
            100                 105                 110         


Val Leu Arg Cys Gln Ala Trp Gln Asp Trp Pro Leu Thr Gln Val Thr 
        115                 120                 125             


Phe Tyr Arg Asp Gly Ser Ala Leu Gly Pro Pro Gly Pro Asn Arg Glu 
    130                 135                 140                 


Phe Ser Ile Thr Val Val Gln Lys Ala Asp Ser Gly His Tyr His Cys 
145                 150                 155                 160 


Ser Gly Ile Phe Gln Ser Pro Gly Pro Gly Ile Pro Glu Thr Ala Ser 
                165                 170                 175     


Val Val Ala Ile Thr Val Gln Glu Leu Phe Pro Ala Pro Ile Leu Arg 
            180                 185                 190         


Ala Val Pro Ser Ala Glu Pro Gln Ala Gly Ser Pro Met Thr Leu Ser 
        195                 200                 205             


Cys Gln Thr Lys Leu Pro Leu Gln Arg Ser Ala Ala Arg Leu Leu Phe 
    210                 215                 220                 


Ser Phe Tyr Lys Asp Gly Arg Ile Val Gln Ser Arg Gly Leu Ser Ser 
225                 230                 235                 240 


Glu Phe Gln Ile Pro Thr Ala Ser Glu Asp His Ser Gly Ser Tyr Trp 
                245                 250                 255     


Cys Glu Ala Ala Thr Glu Asp Asn Gln Val Trp Lys Gln Ser Pro Gln 
            260                 265                 270         


Leu Glu Ile Arg Val Gln Gly Ala Ser Ser Ser Ala Ala Pro Pro Thr 
        275                 280                 285             


Leu Asn Pro Ala Pro Gln Lys Ser Ala Ala Pro Gly Thr Ala Pro Glu 
    290                 295                 300                 


Glu Ala Pro Gly Pro Leu Pro Pro Pro Pro Thr Pro Ser Ser Glu Asp 
305                 310                 315                 320 


Pro Gly Phe Ser Ser Pro Leu Gly Met Pro Asp Pro His Leu Tyr His 
                325                 330                 335     


Gln Met Gly Leu Leu Leu Lys His Met Gln Asp Val Arg Val Leu Leu 
            340                 345                 350         


Gly His Leu Leu Met Glu Leu Arg Glu Leu Ser Gly His Arg Lys Pro 
        355                 360                 365             


Gly Thr Thr Lys Ala Thr Ala Glu 
    370                 375     


<210>  5247
<211>  287
<212>  PRT
<213>  Homo Sapiens

<400>  5247

Met Leu Lys Lys Ile Ser Val Gly Val Ala Gly Asp Leu Asn Thr Val 
1               5                   10                  15      


Thr Met Lys Leu Gly Cys Val Leu Met Ala Trp Ala Leu Tyr Leu Ser 
            20                  25                  30          


Leu Gly Val Leu Trp Val Ala Gln Met Leu Leu Ala Ala Ser Phe Glu 
        35                  40                  45              


Thr Leu Gln Cys Glu Gly Pro Val Cys Thr Glu Glu Ser Ser Cys His 
    50                  55                  60                  


Thr Glu Asp Asp Leu Thr Asp Ala Arg Glu Ala Gly Phe Gln Val Lys 
65                  70                  75                  80  


Ala Tyr Thr Phe Ser Glu Pro Phe His Leu Ile Val Ser Tyr Glu Leu 
                85                  90                  95      


Phe Pro Ala Pro Ile Leu Arg Ala Val Pro Ser Ala Glu Pro Gln Ala 
            100                 105                 110         


Gly Ser Pro Met Thr Leu Ser Cys Gln Thr Lys Leu Pro Leu Gln Arg 
        115                 120                 125             


Ser Ala Ala Arg Leu Leu Phe Ser Phe Tyr Lys Asp Gly Arg Ile Val 
    130                 135                 140                 


Gln Ser Arg Gly Leu Ser Ser Glu Phe Gln Ile Pro Thr Ala Ser Glu 
145                 150                 155                 160 


Asp His Ser Gly Ser Tyr Trp Cys Glu Ala Ala Thr Glu Asp Asn Gln 
                165                 170                 175     


Val Trp Lys Gln Ser Pro Gln Leu Glu Ile Arg Val Gln Gly Ala Ser 
            180                 185                 190         


Ser Ser Ala Ala Pro Pro Thr Leu Asn Pro Ala Pro Gln Lys Ser Ala 
        195                 200                 205             


Ala Pro Gly Thr Ala Pro Glu Glu Ala Pro Gly Pro Leu Pro Pro Pro 
    210                 215                 220                 


Pro Thr Pro Ser Ser Glu Asp Pro Gly Phe Ser Ser Pro Leu Gly Met 
225                 230                 235                 240 


Pro Asp Pro His Leu Tyr His Gln Met Gly Leu Leu Leu Lys His Met 
                245                 250                 255     


Gln Asp Val Arg Val Leu Leu Gly His Leu Leu Met Glu Leu Arg Glu 
            260                 265                 270         


Leu Ser Gly His Arg Lys Pro Gly Thr Thr Lys Ala Thr Ala Glu 
        275                 280                 285         


<210>  5248
<211>  192
<212>  PRT
<213>  Homo Sapiens

<400>  5248

Met Leu Lys Lys Ile Ser Val Gly Val Ala Gly Asp Leu Asn Thr Val 
1               5                   10                  15      


Thr Met Lys Leu Gly Cys Val Leu Met Ala Trp Ala Leu Tyr Leu Ser 
            20                  25                  30          


Leu Gly Val Leu Trp Val Ala Gln Met Leu Leu Ala Ala Ser Phe Glu 
        35                  40                  45              


Thr Leu Gln Cys Glu Gly Pro Val Cys Thr Glu Glu Ser Ser Cys His 
    50                  55                  60                  


Thr Glu Asp Asp Leu Thr Asp Ala Arg Glu Ala Gly Phe Gln Val Lys 
65                  70                  75                  80  


Ala Tyr Thr Phe Ser Glu Pro Phe His Leu Ile Val Ser Tyr Gly Ala 
                85                  90                  95      


Ser Ser Ser Ala Ala Pro Pro Thr Leu Asn Pro Ala Pro Gln Lys Ser 
            100                 105                 110         


Ala Ala Pro Gly Thr Ala Pro Glu Glu Ala Pro Gly Pro Leu Pro Pro 
        115                 120                 125             


Pro Pro Thr Pro Ser Ser Glu Asp Pro Gly Phe Ser Ser Pro Leu Gly 
    130                 135                 140                 


Met Pro Asp Pro His Leu Tyr His Gln Met Gly Leu Leu Leu Lys His 
145                 150                 155                 160 


Met Gln Asp Val Arg Val Leu Leu Gly His Leu Leu Met Glu Leu Arg 
                165                 170                 175     


Glu Leu Ser Gly His Arg Lys Pro Gly Thr Thr Lys Ala Thr Ala Glu 
            180                 185                 190         


<210>  5249
<211>  236
<212>  PRT
<213>  Homo Sapiens

<400>  5249

Met Leu Lys Lys Ile Ser Val Gly Val Ala Gly Asp Leu Asn Thr Val 
1               5                   10                  15      


Thr Met Lys Leu Gly Cys Val Leu Met Ala Trp Ala Leu Tyr Leu Ser 
            20                  25                  30          


Leu Gly Val Leu Trp Val Ala Gln Met Leu Leu Glu Leu Phe Pro Ala 
        35                  40                  45              


Pro Ile Leu Arg Ala Val Pro Ser Ala Glu Pro Gln Ala Gly Ser Pro 
    50                  55                  60                  


Met Thr Leu Ser Cys Gln Thr Lys Leu Pro Leu Gln Arg Ser Ala Ala 
65                  70                  75                  80  


Arg Leu Leu Phe Ser Phe Tyr Lys Asp Gly Arg Ile Val Gln Ser Arg 
                85                  90                  95      


Gly Leu Ser Ser Glu Phe Gln Ile Pro Thr Ala Ser Glu Asp His Ser 
            100                 105                 110         


Gly Ser Tyr Trp Cys Glu Ala Ala Thr Glu Asp Asn Gln Val Trp Lys 
        115                 120                 125             


Gln Ser Pro Gln Leu Glu Ile Arg Val Gln Gly Ala Ser Ser Ser Ala 
    130                 135                 140                 


Ala Pro Pro Thr Leu Asn Pro Ala Pro Gln Lys Ser Ala Ala Pro Gly 
145                 150                 155                 160 


Thr Ala Pro Glu Glu Ala Pro Gly Pro Leu Pro Pro Pro Pro Thr Pro 
                165                 170                 175     


Ser Ser Glu Asp Pro Gly Phe Ser Ser Pro Leu Gly Met Pro Asp Pro 
            180                 185                 190         


His Leu Tyr His Gln Met Gly Leu Leu Leu Lys His Met Gln Asp Val 
        195                 200                 205             


Arg Val Leu Leu Gly His Leu Leu Met Glu Leu Arg Glu Leu Ser Gly 
    210                 215                 220                 


His Arg Lys Pro Gly Thr Thr Lys Ala Thr Ala Glu 
225                 230                 235     


<210>  5250
<211>  141
<212>  PRT
<213>  Homo Sapiens

<400>  5250

Met Leu Lys Lys Ile Ser Val Gly Val Ala Gly Asp Leu Asn Thr Val 
1               5                   10                  15      


Thr Met Lys Leu Gly Cys Val Leu Met Ala Trp Ala Leu Tyr Leu Ser 
            20                  25                  30          


Leu Gly Val Leu Trp Val Ala Gln Met Leu Leu Gly Ala Ser Ser Ser 
        35                  40                  45              


Ala Ala Pro Pro Thr Leu Asn Pro Ala Pro Gln Lys Ser Ala Ala Pro 
    50                  55                  60                  


Gly Thr Ala Pro Glu Glu Ala Pro Gly Pro Leu Pro Pro Pro Pro Thr 
65                  70                  75                  80  


Pro Ser Ser Glu Asp Pro Gly Phe Ser Ser Pro Leu Gly Met Pro Asp 
                85                  90                  95      


Pro His Leu Tyr His Gln Met Gly Leu Leu Leu Lys His Met Gln Asp 
            100                 105                 110         


Val Arg Val Leu Leu Gly His Leu Leu Met Glu Leu Arg Glu Leu Ser 
        115                 120                 125             


Gly His Arg Lys Pro Gly Thr Thr Lys Ala Thr Ala Glu 
    130                 135                 140     


<210>  5251
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  5251

Met Leu Leu Ala Ala Ser Phe Glu Thr Leu Gln Cys Glu Gly Pro Val 
1               5                   10                  15      


Cys Thr Glu Glu Ser Ser Cys His Thr Glu Asp Asp Leu Thr Asp Ala 
            20                  25                  30          


Arg Glu Ala Gly Phe Gln Val Lys Ala Tyr Thr Phe Ser Glu Pro Phe 
        35                  40                  45              


His Leu Ile Val Ser Tyr Gly Ala Ser Ser Ser Ala Ala Pro Pro Thr 
    50                  55                  60                  


Leu Asn Pro Ala Pro Gln Lys Ser Ala Ala Pro Gly Thr Ala Pro Glu 
65                  70                  75                  80  


Glu Ala Pro Gly Pro Leu Pro Pro Pro Pro Thr Pro Ser Ser Glu Asp 
                85                  90                  95      


Pro Gly Phe Ser Ser Pro Leu Gly Met Pro Asp Pro His Leu Tyr His 
            100                 105                 110         


Gln Met Gly Leu Leu Leu Lys His Met Gln Asp Val Arg Val Leu Leu 
        115                 120                 125             


Gly His Leu Leu Met Glu Leu Arg Glu Leu Ser Gly His Arg Lys Pro 
    130                 135                 140                 


Gly Thr Thr Lys Ala Thr Ala Glu 
145                 150         


<210>  5252
<211>  311
<212>  PRT
<213>  Homo Sapiens

<400>  5252

Met Trp Pro Leu Thr Ala Leu Leu Leu Leu Ala Thr Leu Glu Lys Pro 
1               5                   10                  15      


Ile Leu Ser Leu His Pro Pro Trp Thr Thr Ile Phe Lys Gly Glu Arg 
            20                  25                  30          


Val Thr Leu Lys Cys Asp Gly Tyr His Pro Leu Leu Leu Glu Leu Gln 
        35                  40                  45              


Pro Ile Ser Thr Leu Trp Tyr Leu Gly His Leu Leu Leu Pro Ser His 
    50                  55                  60                  


Lys Lys Ser Ile Glu Val Gln Thr Pro Gly Val Tyr Arg Cys Gln Thr 
65                  70                  75                  80  


Arg Gly Ala Pro Val Ser Asp Pro Ile His Leu Ser Val Ser Asn Asp 
                85                  90                  95      


Trp Leu Ile Leu Gln Val Pro Tyr Ala Pro Val Phe Glu Gly Glu Pro 
            100                 105                 110         


Leu Val Leu Arg Cys Arg Gly Trp Tyr Asp Lys Val Val Tyr Lys Leu 
        115                 120                 125             


His Tyr Tyr His Asp Gly Gln Ala Val Arg Tyr Phe His Ser Ser Ala 
    130                 135                 140                 


Asn Tyr Thr Val Leu Gln Ala Arg Ala Ser Asp Ser Gly Arg Tyr Gln 
145                 150                 155                 160 


Cys Ser Gly Thr Met Arg Ile Pro Val Glu Ser Ala Pro Met Phe Ser 
                165                 170                 175     


Ala Lys Val Ala Val Thr Val Gln Ala Ala Arg Cys Ala Ala Ser Thr 
            180                 185                 190         


Gly Ala Pro Ser Thr Gln Ser Arg Ser Pro Arg Ser Arg Ser Ser Asn 
        195                 200                 205             


Arg Thr Gly Ala Arg Arg Leu Pro Pro Pro Ala Val Ser Gly Asn Ala 
    210                 215                 220                 


Val Arg Gly Cys Ser Ser Arg Gly Arg Val Leu Pro Trp Thr Arg Pro 
225                 230                 235                 240 


Pro Pro Pro Pro Gln Leu His Gly Pro Gln Pro Trp Leu Leu Val Ile 
                245                 250                 255     


Gly Arg Phe Pro Ser Glu Ser Pro Arg Cys Pro Asp Arg Ser Arg Trp 
            260                 265                 270         


Ser Pro Pro Ser Gly Thr Pro Pro Pro Pro Gly Cys Ser Ser Arg Arg 
        275                 280                 285             


Ala Ala Pro Arg Leu Arg Gly His Pro Pro Ala Leu Arg Arg Arg Pro 
    290                 295                 300                 


Trp Asn Asn Arg Leu Glu Pro 
305                 310     


<210>  5253
<211>  268
<212>  PRT
<213>  Homo Sapiens

<400>  5253

Met Trp Pro Leu Thr Ala Leu Leu Leu Leu Ala Thr Leu Glu Lys Pro 
1               5                   10                  15      


Ile Leu Ser Leu His Pro Pro Trp Thr Thr Ile Phe Lys Gly Glu Arg 
            20                  25                  30          


Val Thr Leu Lys Cys Asp Gly Tyr His Pro Leu Leu Leu Glu Leu Gln 
        35                  40                  45              


Pro Ile Ser Thr Leu Trp Tyr Leu Gly His Leu Leu Leu Pro Ser His 
    50                  55                  60                  


Lys Lys Ser Ile Glu Val Gln Thr Pro Gly Val Tyr Arg Cys Gln Thr 
65                  70                  75                  80  


Arg Gly Ala Pro Val Ser Asp Pro Ile His Leu Ser Val Ser Asn Asp 
                85                  90                  95      


Trp Leu Ile Leu Gln Val Pro Tyr Ala Pro Val Phe Glu Gly Glu Pro 
            100                 105                 110         


Leu Val Leu Arg Cys Arg Gly Trp Tyr Asp Lys Val Val Tyr Lys Leu 
        115                 120                 125             


His Tyr Tyr His Asp Gly Gln Ala Val Arg Tyr Phe His Ser Ser Ala 
    130                 135                 140                 


Asn Tyr Thr Val Leu Gln Ala Arg Ala Ser Asp Ser Gly Arg Tyr Gln 
145                 150                 155                 160 


Cys Ser Gly Thr Met Arg Ile Pro Val Glu Ser Ala Pro Met Phe Ser 
                165                 170                 175     


Ala Lys Val Ala Val Thr Val Gln Glu Ala Arg His Ala Ala Ala Val 
            180                 185                 190         


Arg Val Leu Gln Val Gln Pro Arg Gly Ala Pro Leu Arg Leu Gly Arg 
        195                 200                 205             


Arg Val His Ser Pro Gly Ala Arg Gly Arg Gly Ala Arg Ile Val Leu 
    210                 215                 220                 


Val Arg Gly Gly Tyr Arg His Pro Gln Cys Pro Glu Thr Gln Ser Val 
225                 230                 235                 240 


Ala Ala Ala Pro Gly Ala Gly Phe Ser Pro Gly Pro Gly Leu His His 
                245                 250                 255     


Arg Pro Ser Ser Met Gly Arg Ser Leu Gly Ser Trp 
            260                 265             


<210>  5254
<211>  318
<212>  PRT
<213>  Homo Sapiens

<400>  5254

Met Trp Pro Leu Thr Ala Leu Leu Leu Leu Val Pro Ser Ser Gly Gln 
1               5                   10                  15      


Ala Ala Thr Leu Glu Lys Pro Ile Leu Ser Leu His Pro Pro Trp Thr 
            20                  25                  30          


Thr Ile Phe Lys Gly Glu Arg Val Thr Leu Lys Cys Asp Gly Tyr His 
        35                  40                  45              


Pro Leu Leu Leu Glu Leu Gln Pro Ile Ser Thr Leu Trp Tyr Leu Gly 
    50                  55                  60                  


His Leu Leu Leu Pro Ser His Lys Lys Ser Ile Glu Val Gln Thr Pro 
65                  70                  75                  80  


Gly Val Tyr Arg Cys Gln Thr Arg Gly Ala Pro Val Ser Asp Pro Ile 
                85                  90                  95      


His Leu Ser Val Ser Asn Asp Trp Leu Ile Leu Gln Val Pro Tyr Ala 
            100                 105                 110         


Pro Val Phe Glu Gly Glu Pro Leu Val Leu Arg Cys Arg Gly Trp Tyr 
        115                 120                 125             


Asp Lys Val Val Tyr Lys Leu His Tyr Tyr His Asp Gly Gln Ala Val 
    130                 135                 140                 


Arg Tyr Phe His Ser Ser Ala Asn Tyr Thr Val Leu Gln Ala Arg Ala 
145                 150                 155                 160 


Ser Asp Ser Gly Arg Tyr Gln Cys Ser Gly Thr Met Arg Ile Pro Val 
                165                 170                 175     


Glu Ser Ala Pro Met Phe Ser Ala Lys Val Ala Val Thr Val Gln Ala 
            180                 185                 190         


Ala Arg Cys Ala Ala Ser Thr Gly Ala Pro Ser Thr Gln Ser Arg Ser 
        195                 200                 205             


Pro Arg Ser Arg Ser Ser Asn Arg Thr Gly Ala Arg Arg Leu Pro Pro 
    210                 215                 220                 


Pro Ala Val Ser Gly Asn Ala Val Arg Gly Cys Ser Ser Arg Gly Arg 
225                 230                 235                 240 


Val Leu Pro Trp Thr Arg Pro Pro Pro Pro Pro Gln Leu His Gly Pro 
                245                 250                 255     


Gln Pro Trp Leu Leu Val Ile Gly Arg Phe Pro Ser Glu Ser Pro Arg 
            260                 265                 270         


Cys Pro Asp Arg Ser Arg Trp Ser Pro Pro Ser Gly Thr Pro Pro Pro 
        275                 280                 285             


Pro Gly Cys Ser Ser Arg Arg Ala Ala Pro Arg Leu Arg Gly His Pro 
    290                 295                 300                 


Pro Ala Leu Arg Arg Arg Pro Trp Asn Asn Arg Leu Glu Pro 
305                 310                 315             


<210>  5255
<211>  275
<212>  PRT
<213>  Homo Sapiens

<400>  5255

Met Trp Pro Leu Thr Ala Leu Leu Leu Leu Val Pro Ser Ser Gly Gln 
1               5                   10                  15      


Ala Ala Thr Leu Glu Lys Pro Ile Leu Ser Leu His Pro Pro Trp Thr 
            20                  25                  30          


Thr Ile Phe Lys Gly Glu Arg Val Thr Leu Lys Cys Asp Gly Tyr His 
        35                  40                  45              


Pro Leu Leu Leu Glu Leu Gln Pro Ile Ser Thr Leu Trp Tyr Leu Gly 
    50                  55                  60                  


His Leu Leu Leu Pro Ser His Lys Lys Ser Ile Glu Val Gln Thr Pro 
65                  70                  75                  80  


Gly Val Tyr Arg Cys Gln Thr Arg Gly Ala Pro Val Ser Asp Pro Ile 
                85                  90                  95      


His Leu Ser Val Ser Asn Asp Trp Leu Ile Leu Gln Val Pro Tyr Ala 
            100                 105                 110         


Pro Val Phe Glu Gly Glu Pro Leu Val Leu Arg Cys Arg Gly Trp Tyr 
        115                 120                 125             


Asp Lys Val Val Tyr Lys Leu His Tyr Tyr His Asp Gly Gln Ala Val 
    130                 135                 140                 


Arg Tyr Phe His Ser Ser Ala Asn Tyr Thr Val Leu Gln Ala Arg Ala 
145                 150                 155                 160 


Ser Asp Ser Gly Arg Tyr Gln Cys Ser Gly Thr Met Arg Ile Pro Val 
                165                 170                 175     


Glu Ser Ala Pro Met Phe Ser Ala Lys Val Ala Val Thr Val Gln Glu 
            180                 185                 190         


Ala Arg His Ala Ala Ala Val Arg Val Leu Gln Val Gln Pro Arg Gly 
        195                 200                 205             


Ala Pro Leu Arg Leu Gly Arg Arg Val His Ser Pro Gly Ala Arg Gly 
    210                 215                 220                 


Arg Gly Ala Arg Ile Val Leu Val Arg Gly Gly Tyr Arg His Pro Gln 
225                 230                 235                 240 


Cys Pro Glu Thr Gln Ser Val Ala Ala Ala Pro Gly Ala Gly Phe Ser 
                245                 250                 255     


Pro Gly Pro Gly Leu His His Arg Pro Ser Ser Met Gly Arg Ser Leu 
            260                 265                 270         


Gly Ser Trp 
        275 


<210>  5256
<211>  426
<212>  PRT
<213>  Homo Sapiens

<400>  5256

Met Trp Pro Leu Thr Ala Leu Leu Leu Leu Val Pro Ser Ser Gly Gln 
1               5                   10                  15      


Ala Ala Thr Leu Glu Lys Pro Ile Leu Ser Leu His Pro Pro Trp Thr 
            20                  25                  30          


Thr Ile Phe Lys Gly Glu Arg Val Thr Leu Lys Cys Asp Gly Tyr His 
        35                  40                  45              


Pro Leu Leu Leu Glu Leu Gln Pro Ile Ser Thr Leu Trp Tyr Leu Gly 
    50                  55                  60                  


His Leu Leu Leu Pro Ser His Lys Lys Ser Ile Glu Val Gln Thr Pro 
65                  70                  75                  80  


Gly Val Tyr Arg Cys Gln Thr Arg Gly Ala Pro Val Ser Asp Pro Ile 
                85                  90                  95      


His Leu Ser Val Ser Asn Asp Trp Leu Ile Leu Gln Val Pro Tyr Ala 
            100                 105                 110         


Pro Val Phe Glu Gly Glu Pro Leu Val Leu Arg Cys Arg Gly Trp Tyr 
        115                 120                 125             


Asp Lys Val Val Tyr Lys Leu His Tyr Tyr His Asp Gly Gln Ala Val 
    130                 135                 140                 


Arg Tyr Phe His Ser Ser Ala Asn Tyr Thr Val Leu Gln Ala Arg Ala 
145                 150                 155                 160 


Ser Asp Ser Gly Arg Tyr Gln Cys Ser Gly Thr Met Arg Ile Pro Val 
                165                 170                 175     


Glu Ser Ala Pro Met Phe Ser Ala Lys Val Ala Val Thr Val Gln Glu 
            180                 185                 190         


Leu Phe Arg Ala Pro Val Leu Arg Val Met Gly Pro Arg Glu Ala Arg 
        195                 200                 205             


Gly Ala Ala Leu Gly Gly Val Val Leu Arg Cys Asp Thr Arg Leu His 
    210                 215                 220                 


Pro Gln Lys Arg Asp Thr Pro Leu Gln Phe Ala Phe Tyr Lys Tyr Ser 
225                 230                 235                 240 


Arg Ala Val Arg Arg Phe Asp Trp Gly Ala Glu Tyr Thr Val Pro Glu 
                245                 250                 255     


Pro Glu Val Glu Glu Leu Glu Ser Tyr Trp Cys Glu Ala Ala Thr Ala 
            260                 265                 270         


Thr Arg Ser Val Arg Lys Arg Ser Pro Trp Leu Gln Leu Pro Gly Pro 
        275                 280                 285             


Gly Ser Pro Leu Asp Pro Ala Ser Thr Thr Ala Pro Ala Pro Trp Ala 
    290                 295                 300                 


Ala Ala Leu Ala Pro Gly Asn Arg Pro Leu Ser Phe Arg Lys Pro Pro 
305                 310                 315                 320 


Val Ser Arg Ser Val Pro Leu Val Thr Ser Val Arg Asn Thr Thr Ser 
                325                 330                 335     


Thr Gly Leu Gln Phe Pro Ala Ser Gly Ala Pro Thr Ala Gly Pro Pro 
            340                 345                 350         


Ala Cys Ala Pro Pro Thr Pro Leu Glu Gln Ser Ala Gly Ala Leu Lys 
        355                 360                 365             


Pro Asp Val Asp Leu Leu Leu Arg Glu Met Gln Leu Leu Lys Gly Leu 
    370                 375                 380                 


Leu Ser Arg Val Val Leu Glu Leu Lys Glu Pro Gln Ala Leu Arg Glu 
385                 390                 395                 400 


Leu Arg Gly Thr Pro Glu Thr Pro Thr Ser His Phe Ala Val Ser Pro 
                405                 410                 415     


Gly Thr Pro Glu Thr Thr Pro Val Glu Ser 
            420                 425     


<210>  5257
<211>  85
<212>  PRT
<213>  Homo Sapiens

<400>  5257

Met Lys Lys Val Leu Leu Leu Ile Thr Ala Ile Leu Ala Val Ala Val 
1               5                   10                  15      


Gly Phe Pro Val Ser Gln Asp Gln Glu Arg Glu Lys Arg Ser Ile Ser 
            20                  25                  30          


Asp Ser Asp Glu Leu Ala Ser Gly Phe Phe Val Phe Pro Tyr Pro Tyr 
        35                  40                  45              


Pro Phe Arg Pro Leu Pro Pro Ile Pro Phe Pro Arg Phe Pro Trp Phe 
    50                  55                  60                  


Arg Arg Asn Phe Pro Ile Pro Ile Pro Glu Ser Ala Pro Thr Thr Pro 
65                  70                  75                  80  


Leu Pro Ser Glu Lys 
                85  


<210>  5258
<211>  317
<212>  PRT
<213>  Homo Sapiens

<400>  5258

Met Gly Leu Leu Leu Pro Leu Ala Leu Cys Ile Leu Val Leu Cys Cys 
1               5                   10                  15      


Gly Ala Met Ser Pro Pro Gln Leu Ala Leu Asn Pro Ser Ala Leu Leu 
            20                  25                  30          


Ser Arg Gly Cys Asn Asp Ser Asp Val Leu Ala Val Ala Gly Phe Ala 
        35                  40                  45              


Leu Arg Asp Ile Asn Lys Asp Arg Lys Asp Gly Tyr Val Leu Arg Leu 
    50                  55                  60                  


Asn Arg Val Asn Asp Ala Gln Glu Tyr Arg Arg Ala Ile Ser Lys Lys 
65                  70                  75                  80  


Lys Ile Tyr Met Thr Cys Pro Asp Cys Pro Ser Ser Ile Pro Thr Asp 
                85                  90                  95      


Ser Ser Asn His Gln Val Leu Glu Ala Ala Thr Glu Ser Leu Ala Lys 
            100                 105                 110         


Tyr Asn Asn Glu Asn Thr Ser Lys Gln Tyr Ser Leu Phe Lys Val Thr 
        115                 120                 125             


Arg Ala Ser Ser Gln Trp Val Val Gly Pro Ser Tyr Phe Val Glu Tyr 
    130                 135                 140                 


Leu Ile Lys Glu Ser Pro Cys Thr Lys Ser Gln Ala Ser Ser Cys Ser 
145                 150                 155                 160 


Leu Gln Ser Ser Asp Ser Val Pro Val Gly Leu Cys Lys Gly Ser Leu 
                165                 170                 175     


Thr Arg Thr His Trp Glu Lys Phe Val Ser Val Thr Cys Asp Phe Phe 
            180                 185                 190         


Glu Ser Gln Ala Pro Ala Thr Gly Ser Glu Asn Ser Ala Val Asn Gln 
        195                 200                 205             


Lys Pro Thr Asn Leu Pro Lys Val Glu Glu Ser Gln Gln Lys Asn Thr 
    210                 215                 220                 


Pro Pro Thr Asp Ser Pro Ser Lys Ala Gly Pro Arg Gly Ser Val Gln 
225                 230                 235                 240 


Tyr Leu Pro Asp Leu Asp Asp Lys Asn Ser Gln Glu Lys Gly Pro Gln 
                245                 250                 255     


Glu Ala Phe Pro Val His Leu Asp Leu Thr Thr Asn Pro Gln Gly Glu 
            260                 265                 270         


Thr Leu Asp Ile Ser Phe Leu Phe Leu Glu Pro Met Glu Glu Lys Leu 
        275                 280                 285             


Val Val Leu Pro Phe Pro Lys Glu Lys Ala Arg Thr Ala Glu Cys Pro 
    290                 295                 300                 


Gly Pro Ala Gln Asn Ala Ser Pro Leu Val Leu Pro Pro 
305                 310                 315         


<210>  5259
<211>  92
<212>  PRT
<213>  Homo Sapiens

<400>  5259

Met Gly Leu Leu Leu Pro Leu Ala Leu Cys Ile Leu Val Leu Cys Cys 
1               5                   10                  15      


Gly Ala Met Ser Pro Pro Gln Leu Ala Leu Asn Pro Ser Ala Leu Leu 
            20                  25                  30          


Ser Arg Gly Cys Asn Asp Ser Asp Val Leu Ala Val Ala Gly Phe Ala 
        35                  40                  45              


Leu Arg Asp Ile Asn Lys Asp Arg Lys Asp Gly Tyr Val Leu Arg Leu 
    50                  55                  60                  


Asn Arg Val Asn Asp Ala Gln Glu Tyr Arg Arg Ala Arg Trp Pro Gly 
65                  70                  75                  80  


Ile Ser Val Leu Ser Tyr Thr Gly Cys Ala Arg Asp 
                85                  90          


<210>  5260
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  5260

Met Gly Leu Leu Leu Pro Leu Ala Leu Cys Ile Leu Val Leu Cys Cys 
1               5                   10                  15      


Gly Ala Met Ser Pro Pro Gln Leu Ala Leu Asn Pro Ser Ala Leu Leu 
            20                  25                  30          


Ser Arg Gly Cys Asn Asp Ser Asp Val Leu Ala Val Ala Gly Phe Ala 
        35                  40                  45              


Leu Arg Asp Ile Asn Lys Asp Arg Lys Asp Gly Tyr Val Leu Arg Leu 
    50                  55                  60                  


Asn Arg Val Asn Asp Ala Gln Glu Tyr Arg Arg Gly Gly Leu Gly Ser 
65                  70                  75                  80  


Leu Phe Tyr Leu Thr Leu Asp Val Leu Glu Thr Asp Cys His Val Leu 
                85                  90                  95      


Arg Lys Lys Ala Trp Gln Asp Cys Gly Met Arg Ile Phe Phe Glu Ser 
            100                 105                 110         


Phe Gln Lys Lys Arg Phe Thr 
        115                 


<210>  5261
<211>  382
<212>  PRT
<213>  Homo Sapiens

<400>  5261

Met Gly Leu Leu Leu Pro Leu Ala Leu Cys Ile Leu Val Leu Cys Cys 
1               5                   10                  15      


Gly Ala Met Ser Pro Pro Gln Leu Ala Leu Asn Pro Ser Ala Leu Leu 
            20                  25                  30          


Ser Arg Gly Cys Asn Asp Ser Asp Val Leu Ala Val Ala Gly Phe Ala 
        35                  40                  45              


Leu Arg Asp Ile Asn Lys Asp Arg Lys Asp Gly Tyr Val Leu Arg Leu 
    50                  55                  60                  


Asn Arg Val Asn Asp Ala Gln Glu Tyr Arg Arg Gly Gly Leu Gly Ser 
65                  70                  75                  80  


Leu Phe Tyr Leu Thr Leu Asp Val Leu Glu Thr Asp Cys His Val Leu 
                85                  90                  95      


Arg Lys Lys Ala Trp Gln Asp Cys Gly Met Arg Ile Phe Phe Glu Ser 
            100                 105                 110         


Val Tyr Gly Gln Cys Lys Ala Ile Phe Tyr Met Asn Asn Pro Ser Arg 
        115                 120                 125             


Val Leu Tyr Leu Ala Ala Tyr Asn Cys Thr Leu Arg Pro Val Ser Lys 
    130                 135                 140                 


Lys Lys Ile Tyr Met Thr Cys Pro Asp Cys Pro Ser Ser Ile Pro Thr 
145                 150                 155                 160 


Asp Ser Ser Asn His Gln Val Leu Glu Ala Ala Thr Glu Ser Leu Ala 
                165                 170                 175     


Lys Tyr Asn Asn Glu Asn Thr Ser Lys Gln Tyr Ser Leu Phe Lys Val 
            180                 185                 190         


Thr Arg Ala Ser Ser Gln Trp Val Val Gly Pro Ser Tyr Phe Val Glu 
        195                 200                 205             


Tyr Leu Ile Lys Glu Ser Pro Cys Thr Lys Ser Gln Ala Ser Ser Cys 
    210                 215                 220                 


Ser Leu Gln Ser Ser Asp Ser Val Pro Val Gly Leu Cys Lys Gly Ser 
225                 230                 235                 240 


Leu Thr Arg Thr His Trp Glu Lys Phe Val Ser Val Thr Cys Asp Phe 
                245                 250                 255     


Phe Glu Ser Gln Ala Pro Ala Thr Gly Ser Glu Asn Ser Ala Val Asn 
            260                 265                 270         


Gln Lys Pro Thr Asn Leu Pro Lys Val Glu Glu Ser Gln Gln Lys Asn 
        275                 280                 285             


Thr Pro Pro Thr Asp Ser Pro Ser Lys Ala Gly Pro Arg Gly Ser Val 
    290                 295                 300                 


Gln Tyr Leu Pro Asp Leu Asp Asp Lys Asn Ser Gln Glu Lys Gly Pro 
305                 310                 315                 320 


Gln Glu Ala Phe Pro Val His Leu Asp Leu Thr Thr Asn Pro Gln Gly 
                325                 330                 335     


Glu Thr Leu Asp Ile Ser Phe Leu Phe Leu Glu Pro Met Glu Glu Lys 
            340                 345                 350         


Leu Val Val Leu Pro Phe Pro Lys Glu Lys Ala Arg Thr Ala Glu Cys 
        355                 360                 365             


Pro Gly Pro Ala Gln Asn Ala Ser Pro Leu Val Leu Pro Pro 
    370                 375                 380         


<210>  5262
<211>  382
<212>  PRT
<213>  Homo Sapiens

<400>  5262

Met Gly Leu Leu Leu Pro Leu Ala Leu Cys Ile Leu Val Leu Cys Cys 
1               5                   10                  15      


Gly Ala Met Ser Pro Pro Gln Leu Ala Leu Asn Pro Ser Ala Leu Leu 
            20                  25                  30          


Ser Arg Gly Cys Asn Asp Ser Asp Val Leu Ala Val Ala Gly Phe Ala 
        35                  40                  45              


Leu Arg Asp Ile Asn Lys Asp Arg Lys Asp Gly Tyr Val Leu Arg Leu 
    50                  55                  60                  


Asn Arg Val Asn Asp Ala Gln Glu Tyr Arg Arg Gly Gly Leu Gly Ser 
65                  70                  75                  80  


Leu Phe Tyr Leu Thr Leu Asp Val Leu Glu Thr Asp Cys His Val Leu 
                85                  90                  95      


Arg Lys Lys Ala Trp Gln Asp Cys Gly Met Arg Ile Phe Phe Glu Ser 
            100                 105                 110         


Val Tyr Gly Gln Cys Lys Ala Ile Phe Tyr Met Asn Asn Pro Ser Arg 
        115                 120                 125             


Val Leu Tyr Leu Ala Ala Tyr Asn Cys Thr Leu Arg Pro Val Ser Lys 
    130                 135                 140                 


Lys Lys Ile Tyr Met Thr Cys Pro Asp Cys Pro Ser Ser Ile Pro Thr 
145                 150                 155                 160 


Asp Ser Ser Asn His Gln Val Leu Glu Ala Ala Thr Glu Ser Leu Ala 
                165                 170                 175     


Lys Tyr Asn Asn Glu Asn Thr Ser Lys Gln Tyr Ser Leu Phe Lys Val 
            180                 185                 190         


Thr Arg Ala Ser Ser Gln Trp Val Val Gly Pro Ser Tyr Phe Val Glu 
        195                 200                 205             


Tyr Leu Ile Lys Glu Ser Pro Cys Thr Lys Ser Gln Ala Ser Ser Cys 
    210                 215                 220                 


Ser Leu Gln Ser Ser Asp Ser Val Pro Val Gly Leu Cys Lys Gly Ser 
225                 230                 235                 240 


Leu Thr Arg Thr His Trp Glu Lys Phe Val Ser Val Thr Cys Asp Phe 
                245                 250                 255     


Phe Glu Ser Gln Ala Pro Ala Thr Gly Ser Glu Asn Ser Ala Val Asn 
            260                 265                 270         


Gln Lys Pro Thr Asn Leu Pro Lys Val Glu Glu Ser Gln Gln Lys Asn 
        275                 280                 285             


Thr Pro Pro Thr Asp Ser Pro Ser Lys Ala Gly Pro Arg Gly Ser Val 
    290                 295                 300                 


Gln Tyr Leu Pro Asp Leu Asp Asp Lys Asn Ser Gln Glu Lys Gly Pro 
305                 310                 315                 320 


Gln Glu Ala Phe Pro Val His Leu Asp Leu Thr Thr Asn Pro Gln Gly 
                325                 330                 335     


Glu Thr Leu Asp Ile Ser Phe Leu Phe Leu Glu Pro Met Glu Glu Lys 
            340                 345                 350         


Leu Val Val Leu Pro Phe Pro Lys Glu Lys Ala Arg Thr Ala Glu Cys 
        355                 360                 365             


Pro Gly Pro Ala Gln Asn Ala Ser Pro Leu Val Leu Pro Pro 
    370                 375                 380         


<210>  5263
<211>  345
<212>  PRT
<213>  Homo Sapiens

<400>  5263

Met Gly Leu Leu Leu Pro Leu Ala Leu Cys Ile Leu Val Leu Cys Cys 
1               5                   10                  15      


Gly Ala Met Ser Pro Pro Gln Leu Ala Leu Asn Pro Ser Ala Leu Leu 
            20                  25                  30          


Ser Arg Gly Cys Asn Asp Ser Asp Val Leu Ala Val Ala Gly Phe Ala 
        35                  40                  45              


Leu Arg Asp Ile Asn Lys Asp Arg Lys Asp Gly Tyr Val Leu Arg Leu 
    50                  55                  60                  


Asn Arg Val Asn Asp Ala Gln Glu Tyr Arg Arg Val Tyr Gly Gln Cys 
65                  70                  75                  80  


Lys Ala Ile Phe Tyr Met Asn Asn Pro Ser Arg Val Leu Tyr Leu Ala 
                85                  90                  95      


Ala Tyr Asn Cys Thr Leu Arg Pro Val Ser Lys Lys Lys Ile Tyr Met 
            100                 105                 110         


Thr Cys Pro Asp Cys Pro Ser Ser Ile Pro Thr Asp Ser Ser Asn His 
        115                 120                 125             


Gln Val Leu Glu Ala Ala Thr Glu Ser Leu Ala Lys Tyr Asn Asn Glu 
    130                 135                 140                 


Asn Thr Ser Lys Gln Tyr Ser Leu Phe Lys Val Thr Arg Ala Ser Ser 
145                 150                 155                 160 


Gln Trp Val Val Gly Pro Ser Tyr Phe Val Glu Tyr Leu Ile Lys Glu 
                165                 170                 175     


Ser Pro Cys Thr Lys Ser Gln Ala Ser Ser Cys Ser Leu Gln Ser Ser 
            180                 185                 190         


Asp Ser Val Pro Val Gly Leu Cys Lys Gly Ser Leu Thr Arg Thr His 
        195                 200                 205             


Trp Glu Lys Phe Val Ser Val Thr Cys Asp Phe Phe Glu Ser Gln Ala 
    210                 215                 220                 


Pro Ala Thr Gly Ser Glu Asn Ser Ala Val Asn Gln Lys Pro Thr Asn 
225                 230                 235                 240 


Leu Pro Lys Val Glu Glu Ser Gln Gln Lys Asn Thr Pro Pro Thr Asp 
                245                 250                 255     


Ser Pro Ser Lys Ala Gly Pro Arg Gly Ser Val Gln Tyr Leu Pro Asp 
            260                 265                 270         


Leu Asp Asp Lys Asn Ser Gln Glu Lys Gly Pro Gln Glu Ala Phe Pro 
        275                 280                 285             


Val His Leu Asp Leu Thr Thr Asn Pro Gln Gly Glu Thr Leu Asp Ile 
    290                 295                 300                 


Ser Phe Leu Phe Leu Glu Pro Met Glu Glu Lys Leu Val Val Leu Pro 
305                 310                 315                 320 


Phe Pro Lys Glu Lys Ala Arg Thr Ala Glu Cys Pro Gly Pro Ala Gln 
                325                 330                 335     


Asn Ala Ser Pro Leu Val Leu Pro Pro 
            340                 345 


<210>  5264
<211>  104
<212>  PRT
<213>  Homo Sapiens

<400>  5264

Met Thr Cys Pro Asp Cys Pro Ser Ser Ile Pro Thr Asp Ser Ser Asn 
1               5                   10                  15      


His Gln Val Leu Glu Ala Ala Thr Glu Ser Leu Ala Lys Tyr Asn Asn 
            20                  25                  30          


Glu Asn Thr Ser Lys Gln Tyr Ser Leu Phe Lys Val Thr Arg Ala Ser 
        35                  40                  45              


Ser Gln Trp Val Val Gly Pro Ser Tyr Phe Val Glu Tyr Leu Ile Lys 
    50                  55                  60                  


Glu Ser Pro Cys Thr Lys Ser Gln Ala Ser Ser Cys Ser Leu Gln Ser 
65                  70                  75                  80  


Ser Asp Ser Val Pro Val Gly Leu Cys Lys Gly Ser Leu Thr Arg Thr 
                85                  90                  95      


His Trp Glu Lys Phe Val Ser Val 
            100                 


<210>  5265
<211>  289
<212>  PRT
<213>  Homo Sapiens

<400>  5265

Met Phe Ser Met Arg Ile Val Cys Leu Val Leu Ser Val Val Gly Thr 
1               5                   10                  15      


Ala Trp Thr Ala Asp Ser Gly Glu Gly Asp Phe Leu Ala Glu Gly Gly 
            20                  25                  30          


Gly Val Arg Gly Pro Arg Val Val Glu Arg His Gln Ser Ala Cys Lys 
        35                  40                  45              


Asp Ser Asp Trp Pro Phe Cys Ser Asp Glu Asp Trp Asn Tyr Lys Cys 
    50                  55                  60                  


Pro Ser Gly Cys Arg Met Lys Gly Leu Ile Asp Glu Val Asn Gln Asp 
65                  70                  75                  80  


Phe Thr Asn Arg Ile Asn Lys Leu Lys Asn Ser Leu Phe Glu Tyr Gln 
                85                  90                  95      


Lys Asn Asn Lys Asp Ser His Ser Leu Thr Thr Asn Ile Met Glu Ile 
            100                 105                 110         


Leu Arg Gly Asp Phe Ser Ser Ala Asn Asn Arg Asp Asn Thr Tyr Asn 
        115                 120                 125             


Arg Val Ser Glu Asp Leu Arg Ser Arg Ile Glu Val Leu Lys Arg Lys 
    130                 135                 140                 


Val Ile Glu Lys Val Gln His Ile Gln Leu Leu Gln Lys Asn Val Arg 
145                 150                 155                 160 


Ala Gln Leu Val Asp Met Lys Arg Leu Glu Val Asp Ile Asp Ile Lys 
                165                 170                 175     


Ile Arg Ser Cys Arg Gly Ser Cys Ser Arg Ala Leu Ala Arg Glu Val 
            180                 185                 190         


Asp Leu Lys Asp Tyr Glu Asp Gln Gln Lys Gln Leu Glu Gln Val Ile 
        195                 200                 205             


Ala Lys Asp Leu Leu Pro Leu Val Asn Leu Gln Val Thr Ala Asn Asn 
    210                 215                 220                 


Leu Leu Val Ala Arg Val Thr Thr Glu Glu Thr Pro His Leu Lys Ala 
225                 230                 235                 240 


Arg Ala Ile Lys Trp Gln Met Arg Pro Glu Val Lys Pro Ile Met Lys 
                245                 250                 255     


Glu His Ile Ala Pro Arg Glu Ala Met Leu Asn Leu Ala Leu Ser Glu 
            260                 265                 270         


Val Ser Thr Leu Leu Leu Trp Gly Ser Leu Pro Cys Pro Pro Arg Leu 
        275                 280                 285             


Ser 
    


<210>  5266
<211>  866
<212>  PRT
<213>  Homo Sapiens

<400>  5266

Met Phe Ser Met Arg Ile Val Cys Leu Val Leu Ser Val Val Gly Thr 
1               5                   10                  15      


Ala Trp Thr Ala Asp Ser Gly Glu Gly Asp Phe Leu Ala Glu Gly Gly 
            20                  25                  30          


Gly Val Arg Gly Pro Arg Val Val Glu Arg His Gln Ser Ala Cys Lys 
        35                  40                  45              


Asp Ser Asp Trp Pro Phe Cys Ser Asp Glu Asp Trp Asn Tyr Lys Cys 
    50                  55                  60                  


Pro Ser Gly Cys Arg Met Lys Gly Leu Ile Asp Glu Val Asn Gln Asp 
65                  70                  75                  80  


Phe Thr Asn Arg Ile Asn Lys Leu Lys Asn Ser Leu Phe Glu Tyr Gln 
                85                  90                  95      


Lys Asn Asn Lys Asp Ser His Ser Leu Thr Thr Asn Ile Met Glu Ile 
            100                 105                 110         


Leu Arg Gly Asp Phe Ser Ser Ala Asn Asn Arg Asp Asn Thr Tyr Asn 
        115                 120                 125             


Arg Val Ser Glu Asp Leu Arg Ser Arg Ile Glu Val Leu Lys Arg Lys 
    130                 135                 140                 


Val Ile Glu Lys Val Gln His Ile Gln Leu Leu Gln Lys Asn Val Arg 
145                 150                 155                 160 


Ala Gln Leu Val Asp Met Lys Arg Leu Glu Val Asp Ile Asp Ile Lys 
                165                 170                 175     


Ile Arg Ser Cys Arg Gly Ser Cys Ser Arg Ala Leu Ala Arg Glu Val 
            180                 185                 190         


Asp Leu Lys Asp Tyr Glu Asp Gln Gln Lys Gln Leu Glu Gln Val Ile 
        195                 200                 205             


Ala Lys Asp Leu Leu Pro Ser Arg Asp Arg Gln His Leu Pro Leu Ile 
    210                 215                 220                 


Lys Met Lys Pro Val Pro Asp Leu Val Pro Gly Asn Phe Lys Ser Gln 
225                 230                 235                 240 


Leu Gln Lys Val Pro Pro Glu Trp Lys Ala Leu Thr Asp Met Pro Gln 
                245                 250                 255     


Met Arg Met Glu Leu Glu Arg Pro Gly Gly Asn Glu Ile Thr Arg Gly 
            260                 265                 270         


Gly Ser Thr Ser Tyr Gly Thr Gly Ser Glu Thr Glu Ser Pro Arg Asn 
        275                 280                 285             


Pro Ser Ser Ala Gly Ser Trp Asn Ser Gly Ser Ser Gly Pro Gly Ser 
    290                 295                 300                 


Thr Gly Asn Arg Asn Pro Gly Ser Ser Gly Thr Gly Gly Thr Ala Thr 
305                 310                 315                 320 


Trp Lys Pro Gly Ser Ser Gly Pro Gly Ser Thr Gly Ser Trp Asn Ser 
                325                 330                 335     


Gly Ser Ser Gly Thr Gly Ser Thr Gly Asn Gln Asn Pro Gly Ser Pro 
            340                 345                 350         


Arg Pro Gly Ser Thr Gly Thr Trp Asn Pro Gly Ser Ser Glu Arg Gly 
        355                 360                 365             


Ser Ala Gly His Trp Thr Ser Glu Ser Ser Val Ser Gly Ser Thr Gly 
    370                 375                 380                 


Gln Trp His Ser Glu Ser Gly Ser Phe Arg Pro Asp Ser Pro Gly Ser 
385                 390                 395                 400 


Gly Asn Ala Arg Pro Asn Asn Pro Asp Trp Gly Thr Phe Glu Glu Val 
                405                 410                 415     


Ser Gly Asn Val Ser Pro Gly Thr Arg Arg Glu Tyr His Thr Glu Lys 
            420                 425                 430         


Leu Val Thr Ser Lys Gly Asp Lys Glu Leu Arg Thr Gly Lys Glu Lys 
        435                 440                 445             


Val Thr Ser Gly Ser Thr Thr Thr Thr Arg Arg Ser Cys Ser Lys Thr 
    450                 455                 460                 


Val Thr Lys Thr Val Ile Gly Pro Asp Gly His Lys Glu Val Thr Lys 
465                 470                 475                 480 


Glu Val Val Thr Ser Glu Asp Gly Ser Asp Cys Pro Glu Ala Met Asp 
                485                 490                 495     


Leu Gly Thr Leu Ser Gly Ile Gly Thr Leu Asp Gly Phe Arg His Arg 
            500                 505                 510         


His Pro Asp Glu Ala Ala Phe Phe Asp Thr Ala Ser Thr Gly Lys Thr 
        515                 520                 525             


Phe Pro Gly Phe Phe Ser Pro Met Leu Gly Glu Phe Val Ser Glu Thr 
    530                 535                 540                 


Glu Ser Arg Gly Ser Glu Ser Gly Ile Phe Thr Asn Thr Lys Glu Ser 
545                 550                 555                 560 


Ser Ser His His Pro Gly Ile Ala Glu Phe Pro Ser Arg Gly Lys Ser 
                565                 570                 575     


Ser Ser Tyr Ser Lys Gln Phe Thr Ser Ser Thr Ser Tyr Asn Arg Gly 
            580                 585                 590         


Asp Ser Thr Phe Glu Ser Lys Ser Tyr Lys Met Ala Asp Glu Ala Gly 
        595                 600                 605             


Ser Glu Ala Asp His Glu Gly Thr His Ser Thr Lys Arg Gly His Ala 
    610                 615                 620                 


Lys Ser Arg Pro Val Arg Asp Cys Asp Asp Val Leu Gln Thr His Pro 
625                 630                 635                 640 


Ser Gly Thr Gln Ser Gly Ile Phe Asn Ile Lys Leu Pro Gly Ser Ser 
                645                 650                 655     


Lys Ile Phe Ser Val Tyr Cys Asp Gln Glu Thr Ser Leu Gly Gly Trp 
            660                 665                 670         


Leu Leu Ile Gln Gln Arg Met Asp Gly Ser Leu Asn Phe Asn Arg Thr 
        675                 680                 685             


Trp Gln Asp Tyr Lys Arg Gly Phe Gly Ser Leu Asn Asp Glu Gly Glu 
    690                 695                 700                 


Gly Glu Phe Trp Leu Gly Asn Asp Tyr Leu His Leu Leu Thr Gln Arg 
705                 710                 715                 720 


Gly Ser Val Leu Arg Val Glu Leu Glu Asp Trp Ala Gly Asn Glu Ala 
                725                 730                 735     


Tyr Ala Glu Tyr His Phe Arg Val Gly Ser Glu Ala Glu Gly Tyr Ala 
            740                 745                 750         


Leu Gln Val Ser Ser Tyr Glu Gly Thr Ala Gly Asp Ala Leu Ile Glu 
        755                 760                 765             


Gly Ser Val Glu Glu Gly Ala Glu Tyr Thr Ser His Asn Asn Met Gln 
    770                 775                 780                 


Phe Ser Thr Phe Asp Arg Asp Ala Asp Gln Trp Glu Glu Asn Cys Ala 
785                 790                 795                 800 


Glu Val Tyr Gly Gly Gly Trp Trp Tyr Asn Asn Cys Gln Ala Ala Asn 
                805                 810                 815     


Leu Asn Gly Ile Tyr Tyr Pro Gly Gly Ser Tyr Asp Pro Arg Asn Asn 
            820                 825                 830         


Ser Pro Tyr Glu Ile Glu Asn Gly Val Val Trp Val Ser Phe Arg Gly 
        835                 840                 845             


Ala Asp Tyr Ser Leu Arg Ala Val Arg Met Lys Ile Arg Pro Leu Val 
    850                 855                 860                 


Thr Gln 
865     


<210>  5267
<211>  644
<212>  PRT
<213>  Homo Sapiens

<400>  5267

Met Phe Ser Met Arg Ile Val Cys Leu Val Leu Ser Val Val Gly Thr 
1               5                   10                  15      


Ala Trp Thr Ala Asp Ser Gly Glu Gly Asp Phe Leu Ala Glu Gly Gly 
            20                  25                  30          


Gly Val Arg Gly Pro Arg Val Val Glu Arg His Gln Ser Ala Cys Lys 
        35                  40                  45              


Asp Ser Asp Trp Pro Phe Cys Ser Asp Glu Asp Trp Asn Tyr Lys Cys 
    50                  55                  60                  


Pro Ser Gly Cys Arg Met Lys Gly Leu Ile Asp Glu Val Asn Gln Asp 
65                  70                  75                  80  


Phe Thr Asn Arg Ile Asn Lys Leu Lys Asn Ser Leu Phe Glu Tyr Gln 
                85                  90                  95      


Lys Asn Asn Lys Asp Ser His Ser Leu Thr Thr Asn Ile Met Glu Ile 
            100                 105                 110         


Leu Arg Gly Asp Phe Ser Ser Ala Asn Asn Arg Asp Asn Thr Tyr Asn 
        115                 120                 125             


Arg Val Ser Glu Asp Leu Arg Ser Arg Ile Glu Val Leu Lys Arg Lys 
    130                 135                 140                 


Val Ile Glu Lys Val Gln His Ile Gln Leu Leu Gln Lys Asn Val Arg 
145                 150                 155                 160 


Ala Gln Leu Val Asp Met Lys Arg Leu Glu Val Asp Ile Asp Ile Lys 
                165                 170                 175     


Ile Arg Ser Cys Arg Gly Ser Cys Ser Arg Ala Leu Ala Arg Glu Val 
            180                 185                 190         


Asp Leu Lys Asp Tyr Glu Asp Gln Gln Lys Gln Leu Glu Gln Val Ile 
        195                 200                 205             


Ala Lys Asp Leu Leu Pro Ser Arg Asp Arg Gln His Leu Pro Leu Ile 
    210                 215                 220                 


Lys Met Lys Pro Val Pro Asp Leu Val Pro Gly Asn Phe Lys Ser Gln 
225                 230                 235                 240 


Leu Gln Lys Val Pro Pro Glu Trp Lys Ala Leu Thr Asp Met Pro Gln 
                245                 250                 255     


Met Arg Met Glu Leu Glu Arg Pro Gly Gly Asn Glu Ile Thr Arg Gly 
            260                 265                 270         


Gly Ser Thr Ser Tyr Gly Thr Gly Ser Glu Thr Glu Ser Pro Arg Asn 
        275                 280                 285             


Pro Ser Ser Ala Gly Ser Trp Asn Ser Gly Ser Ser Gly Pro Gly Ser 
    290                 295                 300                 


Thr Gly Asn Arg Asn Pro Gly Ser Ser Gly Thr Gly Gly Thr Ala Thr 
305                 310                 315                 320 


Trp Lys Pro Gly Ser Ser Gly Pro Gly Ser Thr Gly Ser Trp Asn Ser 
                325                 330                 335     


Gly Ser Ser Gly Thr Gly Ser Thr Gly Asn Gln Asn Pro Gly Ser Pro 
            340                 345                 350         


Arg Pro Gly Ser Thr Gly Thr Trp Asn Pro Gly Ser Ser Glu Arg Gly 
        355                 360                 365             


Ser Ala Gly His Trp Thr Ser Glu Ser Ser Val Ser Gly Ser Thr Gly 
    370                 375                 380                 


Gln Trp His Ser Glu Ser Gly Ser Phe Arg Pro Asp Ser Pro Gly Ser 
385                 390                 395                 400 


Gly Asn Ala Arg Pro Asn Asn Pro Asp Trp Gly Thr Phe Glu Glu Val 
                405                 410                 415     


Ser Gly Asn Val Ser Pro Gly Thr Arg Arg Glu Tyr His Thr Glu Lys 
            420                 425                 430         


Leu Val Thr Ser Lys Gly Asp Lys Glu Leu Arg Thr Gly Lys Glu Lys 
        435                 440                 445             


Val Thr Ser Gly Ser Thr Thr Thr Thr Arg Arg Ser Cys Ser Lys Thr 
    450                 455                 460                 


Val Thr Lys Thr Val Ile Gly Pro Asp Gly His Lys Glu Val Thr Lys 
465                 470                 475                 480 


Glu Val Val Thr Ser Glu Asp Gly Ser Asp Cys Pro Glu Ala Met Asp 
                485                 490                 495     


Leu Gly Thr Leu Ser Gly Ile Gly Thr Leu Asp Gly Phe Arg His Arg 
            500                 505                 510         


His Pro Asp Glu Ala Ala Phe Phe Asp Thr Ala Ser Thr Gly Lys Thr 
        515                 520                 525             


Phe Pro Gly Phe Phe Ser Pro Met Leu Gly Glu Phe Val Ser Glu Thr 
    530                 535                 540                 


Glu Ser Arg Gly Ser Glu Ser Gly Ile Phe Thr Asn Thr Lys Glu Ser 
545                 550                 555                 560 


Ser Ser His His Pro Gly Ile Ala Glu Phe Pro Ser Arg Gly Lys Ser 
                565                 570                 575     


Ser Ser Tyr Ser Lys Gln Phe Thr Ser Ser Thr Ser Tyr Asn Arg Gly 
            580                 585                 590         


Asp Ser Thr Phe Glu Ser Lys Ser Tyr Lys Met Ala Asp Glu Ala Gly 
        595                 600                 605             


Ser Glu Ala Asp His Glu Gly Thr His Ser Thr Lys Arg Gly His Ala 
    610                 615                 620                 


Lys Ser Arg Pro Val Arg Gly Ile His Thr Ser Pro Leu Gly Lys Pro 
625                 630                 635                 640 


Ser Leu Ser Pro 
                


<210>  5268
<211>  272
<212>  PRT
<213>  Homo Sapiens

<400>  5268

Met Glu Tyr Cys Arg Thr Pro Cys Thr Val Ser Cys Asn Ile Pro Val 
1               5                   10                  15      


Val Ser Gly Lys Glu Cys Glu Glu Ile Ile Arg Lys Gly Gly Glu Thr 
            20                  25                  30          


Ser Glu Met Tyr Leu Ile Gln Pro Asp Ser Ser Val Lys Pro Tyr Arg 
        35                  40                  45              


Val Tyr Cys Asp Met Asn Thr Glu Asn Gly Gly Trp Thr Val Ile Gln 
    50                  55                  60                  


Asn Arg Gln Asp Gly Ser Val Asp Phe Gly Arg Lys Trp Asp Pro Tyr 
65                  70                  75                  80  


Lys Gln Gly Phe Gly Asn Val Ala Thr Asn Thr Asp Gly Lys Asn Tyr 
                85                  90                  95      


Cys Gly Leu Pro Gly Glu Tyr Trp Leu Gly Asn Asp Lys Ile Ser Gln 
            100                 105                 110         


Leu Thr Arg Met Gly Pro Thr Glu Leu Leu Ile Glu Met Glu Asp Trp 
        115                 120                 125             


Lys Gly Asp Lys Val Lys Ala His Tyr Gly Gly Phe Thr Val Gln Asn 
    130                 135                 140                 


Glu Ala Asn Lys Tyr Gln Ile Ser Val Asn Lys Tyr Arg Gly Thr Ala 
145                 150                 155                 160 


Gly Asn Ala Leu Met Asp Gly Ala Ser Gln Leu Met Gly Glu Asn Arg 
                165                 170                 175     


Thr Met Thr Ile His Asn Gly Met Phe Phe Ser Thr Tyr Asp Arg Asp 
            180                 185                 190         


Asn Asp Gly Trp Leu Thr Ser Asp Pro Arg Lys Gln Cys Ser Lys Glu 
        195                 200                 205             


Asp Gly Gly Gly Trp Trp Tyr Asn Arg Cys His Ala Ala Asn Pro Asn 
    210                 215                 220                 


Gly Arg Tyr Tyr Trp Gly Gly Gln Tyr Thr Trp Asp Met Ala Lys His 
225                 230                 235                 240 


Gly Thr Asp Asp Gly Val Val Trp Met Asn Trp Lys Gly Ser Trp Tyr 
                245                 250                 255     


Ser Met Arg Lys Met Ser Met Lys Ile Arg Pro Phe Phe Pro Gln Gln 
            260                 265                 270         


<210>  5269
<211>  491
<212>  PRT
<213>  Homo Sapiens

<400>  5269

Met Lys Arg Met Val Ser Trp Ser Phe His Lys Leu Lys Thr Met Lys 
1               5                   10                  15      


His Leu Leu Leu Leu Leu Leu Cys Val Phe Leu Val Lys Ser Gln Gly 
            20                  25                  30          


Val Asn Asp Asn Glu Glu Gly Phe Phe Ser Ala Arg Gly His Arg Pro 
        35                  40                  45              


Leu Asp Lys Lys Arg Glu Glu Ala Pro Ser Leu Arg Pro Ala Pro Pro 
    50                  55                  60                  


Pro Ile Ser Gly Gly Gly Tyr Arg Ala Arg Pro Ala Lys Ala Ala Ala 
65                  70                  75                  80  


Thr Gln Lys Lys Val Glu Arg Lys Ala Pro Asp Ala Gly Gly Cys Leu 
                85                  90                  95      


His Ala Asp Pro Asp Leu Gly Val Leu Cys Pro Thr Gly Cys Gln Leu 
            100                 105                 110         


Gln Glu Ala Leu Leu Gln Gln Glu Arg Pro Ile Arg Asn Ser Val Asp 
        115                 120                 125             


Glu Leu Asn Asn Asn Val Glu Ala Val Ser Gln Thr Ser Ser Ser Ser 
    130                 135                 140                 


Phe Gln Tyr Met Tyr Leu Leu Lys Asp Leu Trp Gln Lys Arg Gln Lys 
145                 150                 155                 160 


Gln Val Lys Asp Asn Glu Asn Val Val Asn Glu Tyr Ser Ser Glu Leu 
                165                 170                 175     


Glu Lys His Gln Leu Tyr Ile Asp Glu Thr Val Asn Ser Asn Ile Pro 
            180                 185                 190         


Thr Asn Leu Arg Val Leu Arg Ser Ile Leu Glu Asn Leu Arg Ser Lys 
        195                 200                 205             


Ile Gln Lys Leu Glu Ser Asp Val Ser Ala Gln Met Glu Tyr Cys Arg 
    210                 215                 220                 


Thr Pro Cys Thr Val Ser Cys Asn Ile Pro Val Val Ser Gly Lys Glu 
225                 230                 235                 240 


Cys Glu Glu Ile Ile Arg Lys Gly Gly Glu Thr Ser Glu Met Tyr Leu 
                245                 250                 255     


Ile Gln Pro Asp Ser Ser Val Lys Pro Tyr Arg Val Tyr Cys Asp Met 
            260                 265                 270         


Asn Thr Glu Asn Gly Gly Trp Thr Val Ile Gln Asn Arg Gln Asp Gly 
        275                 280                 285             


Ser Val Asp Phe Gly Arg Lys Trp Asp Pro Tyr Lys Gln Gly Phe Gly 
    290                 295                 300                 


Asn Val Ala Thr Asn Thr Asp Gly Lys Asn Tyr Cys Gly Leu Pro Gly 
305                 310                 315                 320 


Glu Tyr Trp Leu Gly Asn Asp Lys Ile Ser Gln Leu Thr Arg Met Gly 
                325                 330                 335     


Pro Thr Glu Leu Leu Ile Glu Met Glu Asp Trp Lys Gly Asp Lys Val 
            340                 345                 350         


Lys Ala His Tyr Gly Gly Phe Thr Val Gln Asn Glu Ala Asn Lys Tyr 
        355                 360                 365             


Gln Ile Ser Val Asn Lys Tyr Arg Gly Thr Ala Gly Asn Ala Leu Met 
    370                 375                 380                 


Asp Gly Ala Ser Gln Leu Met Gly Glu Asn Arg Thr Met Thr Ile His 
385                 390                 395                 400 


Asn Gly Met Phe Phe Ser Thr Tyr Asp Arg Asp Asn Asp Gly Trp Leu 
                405                 410                 415     


Thr Ser Asp Pro Arg Lys Gln Cys Ser Lys Glu Asp Gly Gly Gly Trp 
            420                 425                 430         


Trp Tyr Asn Arg Cys His Ala Ala Asn Pro Asn Gly Arg Tyr Tyr Trp 
        435                 440                 445             


Gly Gly Gln Tyr Thr Trp Asp Met Ala Lys His Gly Thr Asp Asp Gly 
    450                 455                 460                 


Val Val Trp Met Asn Trp Lys Gly Ser Trp Tyr Ser Met Arg Lys Met 
465                 470                 475                 480 


Ser Met Lys Ile Arg Pro Phe Phe Pro Gln Gln 
                485                 490     


<210>  5270
<211>  45
<212>  PRT
<213>  Homo Sapiens

<400>  5270

Met Lys Arg Met Val Ser Trp Ser Phe His Lys Leu Lys Thr Met Lys 
1               5                   10                  15      


His Leu Leu Leu Leu Leu Leu Cys Val Phe Leu Val Lys Ser Gln Gly 
            20                  25                  30          


Val Asn Asp Asn Glu Glu Met Arg Lys Leu Gly His Arg 
        35                  40                  45  


<210>  5271
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  5271

Met Trp Lys Trp Ile Leu Thr His Cys Ala Ser Ala Phe Pro His Leu 
1               5                   10                  15      


Pro Gly Cys Cys Cys Cys Cys Phe Leu Leu Leu Phe Leu Val Ser Ser 
            20                  25                  30          


Val Pro Val Thr Cys Gln Ala Leu Gly Gln Asp Met Val Ser Pro Glu 
        35                  40                  45              


Ala Thr Asn Ser Ser Ser Ser Ser Phe Ser Ser Pro Ser Ser Ala Gly 
    50                  55                  60                  


Arg His 
65      


<210>  5272
<211>  208
<212>  PRT
<213>  Homo Sapiens

<400>  5272

Met Trp Lys Trp Ile Leu Thr His Cys Ala Ser Ala Phe Pro His Leu 
1               5                   10                  15      


Pro Gly Cys Cys Cys Cys Cys Phe Leu Leu Leu Phe Leu Val Ser Ser 
            20                  25                  30          


Val Pro Val Thr Cys Gln Ala Leu Gly Gln Asp Met Val Ser Pro Glu 
        35                  40                  45              


Ala Thr Asn Ser Ser Ser Ser Ser Phe Ser Ser Pro Ser Ser Ala Gly 
    50                  55                  60                  


Arg His Val Arg Ser Tyr Asn His Leu Gln Gly Asp Val Arg Trp Arg 
65                  70                  75                  80  


Lys Leu Phe Ser Phe Thr Lys Tyr Phe Leu Lys Ile Glu Lys Asn Gly 
                85                  90                  95      


Lys Val Ser Gly Thr Lys Lys Glu Asn Cys Pro Tyr Ser Ile Leu Glu 
            100                 105                 110         


Ile Thr Ser Val Glu Ile Gly Val Val Ala Val Lys Ala Ile Asn Ser 
        115                 120                 125             


Asn Tyr Tyr Leu Ala Met Asn Lys Lys Gly Lys Leu Tyr Gly Ser Lys 
    130                 135                 140                 


Glu Phe Asn Asn Asp Cys Lys Leu Lys Glu Arg Ile Glu Glu Asn Gly 
145                 150                 155                 160 


Tyr Asn Thr Tyr Ala Ser Phe Asn Trp Gln His Asn Gly Arg Gln Met 
                165                 170                 175     


Tyr Val Ala Leu Asn Gly Lys Gly Ala Pro Arg Arg Gly Gln Lys Thr 
            180                 185                 190         


Arg Arg Lys Asn Thr Ser Ala His Phe Leu Pro Met Val Val His Ser 
        195                 200                 205             


<210>  5273
<211>  216
<212>  PRT
<213>  Homo Sapiens

<400>  5273

Met Gly Ala Ala Arg Leu Leu Pro Asn Leu Thr Leu Cys Leu Gln Leu 
1               5                   10                  15      


Leu Ile Leu Cys Cys Gln Thr Gln Gly Glu Asn His Pro Ser Pro Asn 
            20                  25                  30          


Phe Asn Gln Tyr Val Arg Asp Gln Gly Ala Met Thr Asp Gln Leu Ser 
        35                  40                  45              


Arg Arg Gln Ile Arg Glu Tyr Gln Leu Tyr Ser Arg Thr Ser Gly Lys 
    50                  55                  60                  


His Val Gln Val Thr Gly Arg Arg Ile Ser Ala Thr Ala Glu Asp Gly 
65                  70                  75                  80  


Asn Lys Phe Ala Lys Leu Ile Val Glu Thr Asp Thr Phe Gly Ser Arg 
                85                  90                  95      


Val Arg Ile Lys Gly Ala Glu Ser Glu Lys Tyr Ile Cys Met Asn Lys 
            100                 105                 110         


Arg Gly Lys Leu Ile Gly Lys Pro Ser Gly Lys Ser Lys Asp Cys Val 
        115                 120                 125             


Phe Thr Glu Ile Val Leu Glu Asn Asn Tyr Thr Ala Phe Gln Asn Ala 
    130                 135                 140                 


Arg His Glu Gly Trp Phe Met Ala Phe Thr Arg Gln Gly Arg Pro Arg 
145                 150                 155                 160 


Gln Ala Ser Arg Ser Arg Gln Asn Gln Arg Glu Ala His Phe Ile Lys 
                165                 170                 175     


Arg Leu Tyr Gln Gly Gln Leu Pro Phe Pro Asn His Ala Glu Lys Gln 
            180                 185                 190         


Lys Gln Phe Glu Phe Val Gly Ser Ala Pro Thr Arg Arg Thr Lys Arg 
        195                 200                 205             


Thr Arg Arg Pro Gln Pro Leu Thr 
    210                 215     


<210>  5274
<211>  205
<212>  PRT
<213>  Homo Sapiens

<400>  5274

Met Gly Ala Ala Arg Leu Leu Pro Asn Leu Thr Leu Cys Leu Gln Leu 
1               5                   10                  15      


Leu Ile Leu Cys Cys Gln Thr Gln Tyr Val Arg Asp Gln Gly Ala Met 
            20                  25                  30          


Thr Asp Gln Leu Ser Arg Arg Gln Ile Arg Glu Tyr Gln Leu Tyr Ser 
        35                  40                  45              


Arg Thr Ser Gly Lys His Val Gln Val Thr Gly Arg Arg Ile Ser Ala 
    50                  55                  60                  


Thr Ala Glu Asp Gly Asn Lys Phe Ala Lys Leu Ile Val Glu Thr Asp 
65                  70                  75                  80  


Thr Phe Gly Ser Arg Val Arg Ile Lys Gly Ala Glu Ser Glu Lys Tyr 
                85                  90                  95      


Ile Cys Met Asn Lys Arg Gly Lys Leu Ile Gly Lys Pro Ser Gly Lys 
            100                 105                 110         


Ser Lys Asp Cys Val Phe Thr Glu Ile Val Leu Glu Asn Asn Tyr Thr 
        115                 120                 125             


Ala Phe Gln Asn Ala Arg His Glu Gly Trp Phe Met Ala Phe Thr Arg 
    130                 135                 140                 


Gln Gly Arg Pro Arg Gln Ala Ser Arg Ser Arg Gln Asn Gln Arg Glu 
145                 150                 155                 160 


Ala His Phe Ile Lys Arg Leu Tyr Gln Gly Gln Leu Pro Phe Pro Asn 
                165                 170                 175     


His Ala Glu Lys Gln Lys Gln Phe Glu Phe Val Gly Ser Ala Pro Thr 
            180                 185                 190         


Arg Arg Thr Lys Arg Thr Arg Arg Pro Gln Pro Leu Thr 
        195                 200                 205 


<210>  5275
<211>  207
<212>  PRT
<213>  Homo Sapiens

<400>  5275

Met Tyr Ser Ala Pro Ser Ala Cys Thr Cys Leu Cys Leu His Phe Leu 
1               5                   10                  15      


Leu Leu Cys Phe Gln Val Gln Val Leu Val Ala Glu Glu Asn Val Asp 
            20                  25                  30          


Phe Arg Ile His Val Glu Asn Gln Thr Arg Ala Arg Asp Asp Val Ser 
        35                  40                  45              


Arg Lys Gln Leu Arg Leu Tyr Gln Leu Tyr Ser Arg Thr Ser Gly Lys 
    50                  55                  60                  


His Ile Gln Val Leu Gly Arg Arg Ile Ser Ala Arg Gly Glu Asp Gly 
65                  70                  75                  80  


Asp Lys Tyr Ala Gln Leu Leu Val Glu Thr Asp Thr Phe Gly Ser Gln 
                85                  90                  95      


Val Arg Ile Lys Gly Lys Glu Thr Glu Phe Tyr Leu Cys Met Asn Arg 
            100                 105                 110         


Lys Gly Lys Leu Val Gly Lys Pro Asp Gly Thr Ser Lys Glu Cys Val 
        115                 120                 125             


Phe Ile Glu Lys Val Leu Glu Asn Asn Tyr Thr Ala Leu Met Ser Ala 
    130                 135                 140                 


Lys Tyr Ser Gly Trp Tyr Val Gly Phe Thr Lys Lys Gly Arg Pro Arg 
145                 150                 155                 160 


Lys Gly Pro Lys Thr Arg Glu Asn Gln Gln Asp Val His Phe Met Lys 
                165                 170                 175     


Arg Tyr Pro Lys Gly Gln Pro Glu Leu Gln Lys Pro Phe Lys Tyr Thr 
            180                 185                 190         


Thr Val Thr Lys Arg Ser Arg Arg Ile Arg Pro Thr His Pro Ala 
        195                 200                 205         


<210>  5276
<211>  216
<212>  PRT
<213>  Homo Sapiens

<400>  5276

Met Arg Ser Gly Cys Val Val Val His Val Trp Ile Leu Ala Gly Leu 
1               5                   10                  15      


Trp Leu Ala Val Ala Gly Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro 
            20                  25                  30          


His Val His Tyr Gly Trp Gly Asp Pro Ile Arg Leu Arg His Leu Tyr 
        35                  40                  45              


Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala 
    50                  55                  60                  


Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His Ser Leu Leu 
65                  70                  75                  80  


Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys Gly Val His 
                85                  90                  95      


Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met Gln Gly Leu 
            100                 105                 110         


Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro 
        115                 120                 125             


Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu Pro Val Ser 
    130                 135                 140                 


Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu 
145                 150                 155                 160 


Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro Glu Glu Pro 
                165                 170                 175     


Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser Ser Pro Leu 
            180                 185                 190         


Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly Leu Glu Ala 
        195                 200                 205             


Val Arg Ser Pro Ser Phe Glu Lys 
    210                 215     


<210>  5277
<211>  209
<212>  PRT
<213>  Homo Sapiens

<400>  5277

Met Asp Ser Asp Glu Thr Gly Phe Glu His Ser Gly Leu Trp Val Ser 
1               5                   10                  15      


Val Leu Ala Gly Leu Leu Leu Gly Ala Cys Gln Ala His Pro Ile Pro 
            20                  25                  30          


Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr 
        35                  40                  45              


Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg 
    50                  55                  60                  


Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu 
65                  70                  75                  80  


Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val 
                85                  90                  95      


Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly 
            100                 105                 110         


Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu 
        115                 120                 125             


Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu 
    130                 135                 140                 


His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly 
145                 150                 155                 160 


Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Leu Pro Glu 
                165                 170                 175     


Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp 
            180                 185                 190         


Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala 
        195                 200                 205             


Ser 
    


<210>  5278
<211>  209
<212>  PRT
<213>  Homo Sapiens

<400>  5278

Met Asp Ser Asp Glu Thr Gly Phe Glu His Ser Gly Leu Trp Val Ser 
1               5                   10                  15      


Val Leu Ala Gly Leu Leu Leu Gly Ala Cys Gln Ala His Pro Ile Pro 
            20                  25                  30          


Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr 
        35                  40                  45              


Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg 
    50                  55                  60                  


Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu 
65                  70                  75                  80  


Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val 
                85                  90                  95      


Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly 
            100                 105                 110         


Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu 
        115                 120                 125             


Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu 
    130                 135                 140                 


His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly 
145                 150                 155                 160 


Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Leu Pro Glu 
                165                 170                 175     


Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp 
            180                 185                 190         


Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala 
        195                 200                 205             


Ser 
    


<210>  5279
<211>  170
<212>  PRT
<213>  Homo Sapiens

<400>  5279

Met Arg Arg Arg Leu Trp Leu Gly Leu Ala Trp Leu Leu Leu Ala Arg 
1               5                   10                  15      


Ala Pro Asp Ala Ala Gly Thr Pro Ser Ala Ser Arg Gly Pro Arg Ser 
            20                  25                  30          


Tyr Pro His Leu Glu Gly Asp Val Arg Trp Arg Arg Leu Phe Ser Ser 
        35                  40                  45              


Thr His Phe Phe Leu Arg Val Asp Pro Gly Gly Arg Val Gln Gly Thr 
    50                  55                  60                  


Arg Trp Arg His Gly Gln Asp Ser Ile Leu Glu Ile Arg Ser Val His 
65                  70                  75                  80  


Val Gly Val Val Val Ile Lys Ala Val Ser Ser Gly Phe Tyr Val Ala 
                85                  90                  95      


Met Asn Arg Arg Gly Arg Leu Tyr Gly Ser Arg Leu Tyr Thr Val Asp 
            100                 105                 110         


Cys Arg Phe Arg Glu Arg Ile Glu Glu Asn Gly His Asn Thr Tyr Ala 
        115                 120                 125             


Ser Gln Arg Trp Arg Arg Arg Gly Gln Pro Met Phe Leu Ala Leu Asp 
    130                 135                 140                 


Arg Arg Gly Gly Pro Arg Pro Gly Gly Arg Thr Arg Arg Tyr His Leu 
145                 150                 155                 160 


Ser Ala His Phe Leu Pro Val Leu Val Ser 
                165                 170 


<210>  5280
<211>  165
<212>  PRT
<213>  Homo Sapiens

<400>  5280

Met Arg Arg Arg Leu Trp Leu Gly Leu Ala Trp Leu Leu Leu Ala Arg 
1               5                   10                  15      


Ala Pro Asp Ala Ala Gly Thr Pro Ser Ala Ser Arg Gly Pro Arg Ser 
            20                  25                  30          


Tyr Pro His Leu Glu Gly Asp Val Arg Trp Arg Arg Leu Phe Ser Ser 
        35                  40                  45              


Thr His Phe Phe Leu Arg Val Asp Pro Gly Gly Arg Val Gln Gly Thr 
    50                  55                  60                  


Arg Trp Arg His Gly Gln Asp Ser Ile Leu Glu Ile Arg Ser Val His 
65                  70                  75                  80  


Val Gly Val Val Val Ile Lys Ala Val Ser Ser Gly Phe Tyr Val Ala 
                85                  90                  95      


Met Asn Arg Arg Gly Arg Leu Tyr Gly Ser Val Pro Gly Ala His Arg 
            100                 105                 110         


Arg Glu Arg Pro Gln His Leu Arg Leu Thr Ala Leu Ala Pro Pro Arg 
        115                 120                 125             


Pro Ala His Val Pro Gly Ala Gly Gln Glu Gly Gly Ala Pro Ala Arg 
    130                 135                 140                 


Arg Pro Asp Ala Ala Val Pro Pro Val Arg Pro Leu Pro Ala Arg Pro 
145                 150                 155                 160 


Gly Leu Leu Arg Pro 
                165 


<210>  5281
<211>  251
<212>  PRT
<213>  Homo Sapiens

<400>  5281

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Tyr Pro Asn Ala Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Asn Ser Tyr His Leu Gln Ile His Lys Asn Gly His Val Asp Gly Ala 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Arg Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Phe Val Val Ile Thr Gly Val Met Ser Arg Arg Tyr Leu Cys Met 
                85                  90                  95      


Asp Phe Arg Gly Asn Ile Phe Gly Ser His Tyr Phe Asp Pro Glu Asn 
            100                 105                 110         


Cys Arg Phe Gln His Gln Thr Leu Glu Asn Gly Tyr Asp Val Tyr His 
        115                 120                 125             


Ser Pro Gln Tyr His Phe Leu Val Ser Leu Gly Arg Ala Lys Arg Ala 
    130                 135                 140                 


Phe Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser Gln Phe Leu Ser Arg 
145                 150                 155                 160 


Arg Asn Glu Ile Pro Leu Ile His Phe Asn Thr Pro Ile Pro Arg Arg 
                165                 170                 175     


His Thr Arg Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly 
225                 230                 235                 240 


Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile 
                245                 250     


<210>  5282
<211>  239
<212>  PRT
<213>  Homo Sapiens

<400>  5282

Met Gly Leu Ile Trp Leu Leu Leu Leu Ser Leu Leu Glu Pro Gly Trp 
1               5                   10                  15      


Pro Ala Ala Gly Pro Gly Ala Arg Leu Arg Arg Asp Ala Gly Gly Arg 
            20                  25                  30          


Gly Gly Val Tyr Glu His Leu Gly Gly Ala Pro Arg Arg Arg Lys Leu 
        35                  40                  45              


Tyr Cys Ala Thr Lys Tyr His Leu Gln Leu His Pro Ser Gly Arg Val 
    50                  55                  60                  


Asn Gly Ser Leu Glu Asn Ser Ala Tyr Ser Ile Leu Glu Ile Thr Ala 
65                  70                  75                  80  


Val Glu Val Gly Ile Val Ala Ile Arg Gly Leu Phe Ser Gly Arg Tyr 
                85                  90                  95      


Leu Ala Met Asn Lys Arg Gly Arg Leu Tyr Ala Ser Glu His Tyr Ser 
            100                 105                 110         


Ala Glu Cys Glu Phe Val Glu Arg Ile His Glu Leu Gly Tyr Asn Thr 
        115                 120                 125             


Tyr Ala Ser Arg Leu Tyr Arg Thr Val Ser Ser Thr Pro Gly Ala Arg 
    130                 135                 140                 


Arg Gln Pro Ser Ala Glu Arg Leu Trp Tyr Val Ser Val Asn Gly Lys 
145                 150                 155                 160 


Gly Arg Pro Arg Arg Gly Phe Lys Thr Arg Arg Thr Gln Lys Ser Ser 
                165                 170                 175     


Leu Phe Leu Pro Arg Val Leu Asp His Arg Asp His Glu Met Val Arg 
            180                 185                 190         


Gln Leu Gln Ser Gly Leu Pro Arg Pro Pro Gly Lys Gly Val Gln Pro 
        195                 200                 205             


Arg Arg Arg Arg Gln Lys Gln Ser Pro Asp Asn Leu Glu Pro Ser His 
    210                 215                 220                 


Val Gln Ala Ser Arg Leu Gly Ser Gln Leu Glu Ala Ser Ala His 
225                 230                 235                 


<210>  5283
<211>  206
<212>  PRT
<213>  Homo Sapiens

<400>  5283

Met Ser Gly Pro Gly Thr Ala Ala Val Ala Leu Leu Pro Ala Val Leu 
1               5                   10                  15      


Leu Ala Leu Leu Ala Pro Trp Ala Gly Arg Gly Gly Ala Ala Ala Pro 
            20                  25                  30          


Thr Ala Pro Asn Gly Thr Leu Glu Ala Glu Leu Glu Arg Arg Trp Glu 
        35                  40                  45              


Ser Leu Val Ala Leu Ser Leu Ala Arg Leu Pro Val Ala Ala Gln Pro 
    50                  55                  60                  


Lys Glu Ala Ala Val Gln Ser Gly Ala Gly Asp Tyr Leu Leu Gly Ile 
65                  70                  75                  80  


Lys Arg Leu Arg Arg Leu Tyr Cys Asn Val Gly Ile Gly Phe His Leu 
                85                  90                  95      


Gln Ala Leu Pro Asp Gly Arg Ile Gly Gly Ala His Ala Asp Thr Arg 
            100                 105                 110         


Asp Ser Leu Leu Glu Leu Ser Pro Val Glu Arg Gly Val Val Ser Ile 
        115                 120                 125             


Phe Gly Val Ala Ser Arg Phe Phe Val Ala Met Ser Ser Lys Gly Lys 
    130                 135                 140                 


Leu Tyr Gly Ser Pro Phe Phe Thr Asp Glu Cys Thr Phe Lys Glu Ile 
145                 150                 155                 160 


Leu Leu Pro Asn Asn Tyr Asn Ala Tyr Glu Ser Tyr Lys Tyr Pro Gly 
                165                 170                 175     


Met Phe Ile Ala Leu Ser Lys Asn Gly Lys Thr Lys Lys Gly Asn Arg 
            180                 185                 190         


Val Ser Pro Thr Met Lys Val Thr His Phe Leu Pro Arg Leu 
        195                 200                 205     


<210>  5284
<211>  123
<212>  PRT
<213>  Homo Sapiens

<400>  5284

Met Ser Leu Ser Phe Leu Leu Leu Leu Phe Phe Ser His Leu Ile Leu 
1               5                   10                  15      


Ser Ala Trp Ala His Gly Glu Lys Arg Leu Ala Pro Lys Gly Gln Pro 
            20                  25                  30          


Gly Pro Ala Ala Thr Asp Arg Asn Pro Arg Gly Ser Ser Ser Arg Gln 
        35                  40                  45              


Ser Ser Ser Ser Ala Met Ser Ser Ser Ser Ala Ser Ser Ser Pro Ala 
    50                  55                  60                  


Ala Ser Leu Gly Ser Gln Gly Ser Gly Leu Glu Gln Ser Ser Phe Gln 
65                  70                  75                  80  


Trp Ser Pro Ser Gly Arg Arg Thr Gly Ser Leu Tyr Cys Arg Val Gly 
                85                  90                  95      


Ile Gly Phe His Leu Gln Ile Tyr Pro Asp Gly Lys Val Asn Gly Ser 
            100                 105                 110         


His Glu Ala Asn Met Leu Ser Gln Val His Arg 
        115                 120             


<210>  5285
<211>  268
<212>  PRT
<213>  Homo Sapiens

<400>  5285

Met Ser Leu Ser Phe Leu Leu Leu Leu Phe Phe Ser His Leu Ile Leu 
1               5                   10                  15      


Ser Ala Trp Ala His Gly Glu Lys Arg Leu Ala Pro Lys Gly Gln Pro 
            20                  25                  30          


Gly Pro Ala Ala Thr Asp Arg Asn Pro Arg Gly Ser Ser Ser Arg Gln 
        35                  40                  45              


Ser Ser Ser Ser Ala Met Ser Ser Ser Ser Ala Ser Ser Ser Pro Ala 
    50                  55                  60                  


Ala Ser Leu Gly Ser Gln Gly Ser Gly Leu Glu Gln Ser Ser Phe Gln 
65                  70                  75                  80  


Trp Ser Pro Ser Gly Arg Arg Thr Gly Ser Leu Tyr Cys Arg Val Gly 
                85                  90                  95      


Ile Gly Phe His Leu Gln Ile Tyr Pro Asp Gly Lys Val Asn Gly Ser 
            100                 105                 110         


His Glu Ala Asn Met Leu Ser Val Leu Glu Ile Phe Ala Val Ser Gln 
        115                 120                 125             


Gly Ile Val Gly Ile Arg Gly Val Phe Ser Asn Lys Phe Leu Ala Met 
    130                 135                 140                 


Ser Lys Lys Gly Lys Leu His Ala Ser Ala Lys Phe Thr Asp Asp Cys 
145                 150                 155                 160 


Lys Phe Arg Glu Arg Phe Gln Glu Asn Ser Tyr Asn Thr Tyr Ala Ser 
                165                 170                 175     


Ala Ile His Arg Thr Glu Lys Thr Gly Arg Glu Trp Tyr Val Ala Leu 
            180                 185                 190         


Asn Lys Arg Gly Lys Ala Lys Arg Gly Cys Ser Pro Arg Val Lys Pro 
        195                 200                 205             


Gln His Ile Ser Thr His Phe Leu Pro Arg Phe Lys Gln Ser Glu Gln 
    210                 215                 220                 


Pro Glu Leu Ser Phe Thr Val Thr Val Pro Glu Lys Lys Lys Pro Pro 
225                 230                 235                 240 


Ser Pro Ile Lys Pro Lys Ile Pro Leu Ser Ala Pro Arg Lys Asn Thr 
                245                 250                 255     


Asn Ser Val Lys Tyr Arg Leu Lys Phe Arg Phe Gly 
            260                 265             


<210>  5286
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  5286

Asn Pro Arg Gly Ser Ser Ser Arg Gln Ser Ser Ser Ser Ala Met Ser 
1               5                   10                  15      


Ser Ser Ser Ala Ser Ser Ser Pro Ala Ala Ser Leu Gly Ser Gln Gly 
            20                  25                  30          


Ser Gly Leu Glu Gln Ser Ser Phe Gln Trp Ser Pro Ser Gly Arg Arg 
        35                  40                  45              


Thr Gly Ser Leu Tyr Cys Arg Val Gly Ile Gly Phe His Leu Gln Ile 
    50                  55                  60                  


Tyr Pro Asp Gly Lys Val Asn Gly Ser His Glu Ala Asn Met Leu Ser 
65                  70                  75                  80  


Val Leu Glu Ile Phe Ala Val Ser Gln Gly Ile Val Gly Ile Arg Gly 
                85                  90                  95      


Val Phe Ser Asn Lys Phe Leu Ala Met Ser Lys Lys Gly Lys Leu His 
            100                 105                 110         


Ala Ser Asn Thr Leu Glu Thr 
        115                 


<210>  5287
<211>  122
<212>  PRT
<213>  Homo Sapiens

<400>  5287

Met Glu Gly Gly Asp Ile Arg Val Arg Arg Leu Phe Cys Arg Thr Gln 
1               5                   10                  15      


Trp Tyr Leu Arg Ile Asp Lys Arg Gly Lys Val Lys Gly Thr Gln Glu 
            20                  25                  30          


Met Lys Asn Asn Tyr Asn Ile Met Glu Ile Arg Thr Val Ala Val Gly 
        35                  40                  45              


Ile Val Ala Ile Lys Gly Val Glu Ser Glu Phe Tyr Leu Ala Met Asn 
    50                  55                  60                  


Lys Glu Gly Lys Leu Tyr Ala Lys Lys Glu Cys Asn Glu Asp Cys Asn 
65                  70                  75                  80  


Phe Lys Glu Leu Ile Leu Glu Asn His Tyr Asn Thr Tyr Ala Ser Ala 
                85                  90                  95      


Lys Trp Thr His Asn Gly Gly Glu Met Phe Val Ala Leu Asn Gln Lys 
            100                 105                 110         


Gly Ile Pro Val Arg Gly Lys Lys Thr Lys 
        115                 120         


<210>  5288
<211>  194
<212>  PRT
<213>  Homo Sapiens

<400>  5288

Met His Lys Trp Ile Leu Thr Trp Ile Leu Pro Thr Leu Leu Tyr Arg 
1               5                   10                  15      


Ser Cys Phe His Ile Ile Cys Leu Val Gly Thr Ile Ser Leu Ala Cys 
            20                  25                  30          


Asn Asp Met Thr Pro Glu Gln Met Ala Thr Asn Val Asn Cys Ser Ser 
        35                  40                  45              


Pro Glu Arg His Thr Arg Ser Tyr Asp Tyr Met Glu Gly Gly Asp Ile 
    50                  55                  60                  


Arg Val Arg Arg Leu Phe Cys Arg Thr Gln Trp Tyr Leu Arg Ile Asp 
65                  70                  75                  80  


Lys Arg Gly Lys Val Lys Gly Thr Gln Glu Met Lys Asn Asn Tyr Asn 
                85                  90                  95      


Ile Met Glu Ile Arg Thr Val Ala Val Gly Ile Val Ala Ile Lys Gly 
            100                 105                 110         


Val Glu Ser Glu Phe Tyr Leu Ala Met Asn Lys Glu Gly Lys Leu Tyr 
        115                 120                 125             


Ala Lys Lys Glu Cys Asn Glu Asp Cys Asn Phe Lys Glu Leu Ile Leu 
    130                 135                 140                 


Glu Asn His Tyr Asn Thr Tyr Ala Ser Ala Lys Trp Thr His Asn Gly 
145                 150                 155                 160 


Gly Glu Met Phe Val Ala Leu Asn Gln Lys Gly Ile Pro Val Arg Gly 
                165                 170                 175     


Lys Lys Thr Lys Lys Glu Gln Lys Thr Ala His Phe Leu Pro Met Ala 
            180                 185                 190         


Ile Thr 
        


<210>  5289
<211>  194
<212>  PRT
<213>  Homo Sapiens

<400>  5289

Met His Lys Trp Ile Leu Thr Trp Ile Leu Pro Thr Leu Leu Tyr Arg 
1               5                   10                  15      


Ser Cys Phe His Ile Ile Cys Leu Val Gly Thr Ile Ser Leu Ala Cys 
            20                  25                  30          


Asn Asp Met Thr Pro Glu Gln Met Ala Thr Asn Val Asn Cys Ser Ser 
        35                  40                  45              


Pro Glu Arg His Thr Arg Ser Tyr Asp Tyr Met Glu Gly Gly Asp Ile 
    50                  55                  60                  


Arg Val Arg Arg Leu Phe Cys Arg Thr Gln Trp Tyr Leu Arg Ile Asp 
65                  70                  75                  80  


Lys Arg Gly Lys Val Lys Gly Thr Gln Glu Met Lys Asn Asn Tyr Asn 
                85                  90                  95      


Ile Met Glu Ile Arg Thr Val Ala Val Gly Ile Val Ala Ile Lys Gly 
            100                 105                 110         


Val Glu Ser Glu Phe Tyr Leu Ala Met Asn Lys Glu Gly Lys Leu Tyr 
        115                 120                 125             


Ala Lys Lys Glu Cys Asn Glu Asp Cys Asn Phe Lys Glu Leu Ile Leu 
    130                 135                 140                 


Glu Asn His Tyr Asn Thr Tyr Ala Ser Ala Lys Trp Thr His Asn Gly 
145                 150                 155                 160 


Gly Glu Met Phe Val Ala Leu Asn Gln Lys Gly Ile Pro Val Arg Gly 
                165                 170                 175     


Lys Lys Thr Lys Lys Glu Gln Lys Thr Ala His Phe Leu Pro Met Ala 
            180                 185                 190         


Ile Thr 
        


<210>  5290
<211>  194
<212>  PRT
<213>  Homo Sapiens

<400>  5290

Met His Lys Trp Ile Leu Thr Trp Ile Leu Pro Thr Leu Leu Tyr Arg 
1               5                   10                  15      


Ser Cys Phe His Ile Ile Cys Leu Val Gly Thr Ile Ser Leu Ala Cys 
            20                  25                  30          


Asn Asp Met Thr Pro Glu Gln Met Ala Thr Asn Val Asn Cys Ser Ser 
        35                  40                  45              


Pro Glu Arg His Thr Arg Ser Tyr Asp Tyr Met Glu Gly Gly Asp Ile 
    50                  55                  60                  


Arg Val Arg Arg Leu Phe Cys Arg Thr Gln Trp Tyr Leu Arg Ile Asp 
65                  70                  75                  80  


Lys Arg Gly Lys Val Lys Gly Thr Gln Glu Met Lys Asn Asn Tyr Asn 
                85                  90                  95      


Ile Met Glu Ile Arg Thr Val Ala Val Gly Ile Val Ala Ile Lys Gly 
            100                 105                 110         


Val Glu Ser Glu Phe Tyr Leu Ala Met Asn Lys Glu Gly Lys Leu Tyr 
        115                 120                 125             


Ala Lys Lys Glu Cys Asn Glu Asp Cys Asn Phe Lys Glu Leu Ile Leu 
    130                 135                 140                 


Glu Asn His Tyr Asn Thr Tyr Ala Ser Ala Lys Trp Thr His Asn Gly 
145                 150                 155                 160 


Gly Glu Met Phe Val Ala Leu Asn Gln Lys Gly Ile Pro Val Arg Gly 
                165                 170                 175     


Lys Lys Thr Lys Lys Glu Gln Lys Thr Ala His Phe Leu Pro Met Ala 
            180                 185                 190         


Ile Thr 
        


<210>  5291
<211>  97
<212>  PRT
<213>  Homo Sapiens

<400>  5291

Met His Lys Trp Ile Leu Thr Trp Ile Leu Pro Thr Leu Leu Tyr Arg 
1               5                   10                  15      


Ser Cys Phe His Ile Ile Cys Leu Val Gly Thr Ile Ser Leu Ala Cys 
            20                  25                  30          


Asn Asp Met Thr Pro Glu Gln Met Ala Thr Asn Val Asn Cys Ser Ser 
        35                  40                  45              


Pro Glu Arg His Thr Arg Ser Tyr Asp Tyr Met Glu Gly Gly Asp Ile 
    50                  55                  60                  


Arg Val Arg Arg Leu Phe Cys Arg Thr Gln Trp Tyr Leu Arg Ile Asp 
65                  70                  75                  80  


Lys Arg Gly Lys Val Lys Gly Thr Gln Glu Met Lys Asn Asn Tyr Ser 
                85                  90                  95      


Lys 
    


<210>  5292
<211>  140
<212>  PRT
<213>  Homo Sapiens

<400>  5292

Met Ala Glu Asp Gly Asp Pro Phe Ala Lys Leu Ile Val Glu Thr Asp 
1               5                   10                  15      


Thr Phe Gly Ser Arg Val Arg Val Arg Gly Ala Glu Thr Gly Leu Tyr 
            20                  25                  30          


Ile Cys Met Asn Lys Lys Gly Lys Leu Ile Ala Lys Ser Asn Gly Lys 
        35                  40                  45              


Gly Lys Asp Cys Val Phe Thr Glu Ile Val Leu Glu Asn Asn Tyr Thr 
    50                  55                  60                  


Ala Leu Gln Asn Ala Lys Tyr Glu Gly Trp Tyr Met Ala Phe Thr Arg 
65                  70                  75                  80  


Lys Gly Arg Pro Arg Lys Gly Ser Lys Thr Arg Gln His Gln Arg Glu 
                85                  90                  95      


Val His Phe Met Lys Arg Leu Pro Arg Gly His His Thr Thr Glu Gln 
            100                 105                 110         


Ser Leu Arg Phe Glu Phe Leu Asn Tyr Pro Pro Phe Thr Arg Ser Leu 
        115                 120                 125             


Arg Gly Ser Gln Arg Thr Trp Ala Pro Glu Pro Arg 
    130                 135                 140 


<210>  5293
<211>  233
<212>  PRT
<213>  Homo Sapiens

<400>  5293

Met Gly Ser Pro Arg Ser Ala Leu Ser Cys Leu Leu Leu His Leu Leu 
1               5                   10                  15      


Val Leu Cys Leu Gln Ala Gln Glu Gly Pro Gly Arg Gly Pro Ala Leu 
            20                  25                  30          


Gly Arg Glu Leu Ala Ser Leu Phe Arg Ala Gly Arg Glu Pro Gln Gly 
        35                  40                  45              


Val Ser Gln Gln His Val Arg Glu Gln Ser Leu Val Thr Asp Gln Leu 
    50                  55                  60                  


Ser Arg Arg Leu Ile Arg Thr Tyr Gln Leu Tyr Ser Arg Thr Ser Gly 
65                  70                  75                  80  


Lys His Val Gln Val Leu Ala Asn Lys Arg Ile Asn Ala Met Ala Glu 
                85                  90                  95      


Asp Gly Asp Pro Phe Ala Lys Leu Ile Val Glu Thr Asp Thr Phe Gly 
            100                 105                 110         


Ser Arg Val Arg Val Arg Gly Ala Glu Thr Gly Leu Tyr Ile Cys Met 
        115                 120                 125             


Asn Lys Lys Gly Lys Leu Ile Ala Lys Ser Asn Gly Lys Gly Lys Asp 
    130                 135                 140                 


Cys Val Phe Thr Glu Ile Val Leu Glu Asn Asn Tyr Thr Ala Leu Gln 
145                 150                 155                 160 


Asn Ala Lys Tyr Glu Gly Trp Tyr Met Ala Phe Thr Arg Lys Gly Arg 
                165                 170                 175     


Pro Arg Lys Gly Ser Lys Thr Arg Gln His Gln Arg Glu Val His Phe 
            180                 185                 190         


Met Lys Arg Leu Pro Arg Gly His His Thr Thr Glu Gln Ser Leu Arg 
        195                 200                 205             


Phe Glu Phe Leu Asn Tyr Pro Pro Phe Thr Arg Ser Leu Arg Gly Ser 
    210                 215                 220                 


Gln Arg Thr Trp Ala Pro Glu Pro Arg 
225                 230             


<210>  5294
<211>  244
<212>  PRT
<213>  Homo Sapiens

<400>  5294

Met Gly Ser Pro Arg Ser Ala Leu Ser Cys Leu Leu Leu His Leu Leu 
1               5                   10                  15      


Val Leu Cys Leu Gln Ala Gln Glu Gly Pro Gly Arg Gly Pro Ala Leu 
            20                  25                  30          


Gly Arg Glu Leu Ala Ser Leu Phe Arg Ala Gly Arg Glu Pro Gln Gly 
        35                  40                  45              


Val Ser Gln Gln Val Thr Val Gln Ser Ser Pro Asn Phe Thr Gln His 
    50                  55                  60                  


Val Arg Glu Gln Ser Leu Val Thr Asp Gln Leu Ser Arg Arg Leu Ile 
65                  70                  75                  80  


Arg Thr Tyr Gln Leu Tyr Ser Arg Thr Ser Gly Lys His Val Gln Val 
                85                  90                  95      


Leu Ala Asn Lys Arg Ile Asn Ala Met Ala Glu Asp Gly Asp Pro Phe 
            100                 105                 110         


Ala Lys Leu Ile Val Glu Thr Asp Thr Phe Gly Ser Arg Val Arg Val 
        115                 120                 125             


Arg Gly Ala Glu Thr Gly Leu Tyr Ile Cys Met Asn Lys Lys Gly Lys 
    130                 135                 140                 


Leu Ile Ala Lys Ser Asn Gly Lys Gly Lys Asp Cys Val Phe Thr Glu 
145                 150                 155                 160 


Ile Val Leu Glu Asn Asn Tyr Thr Ala Leu Gln Asn Ala Lys Tyr Glu 
                165                 170                 175     


Gly Trp Tyr Met Ala Phe Thr Arg Lys Gly Arg Pro Arg Lys Gly Ser 
            180                 185                 190         


Lys Thr Arg Gln His Gln Arg Glu Val His Phe Met Lys Arg Leu Pro 
        195                 200                 205             


Arg Gly His His Thr Thr Glu Gln Ser Leu Arg Phe Glu Phe Leu Asn 
    210                 215                 220                 


Tyr Pro Pro Phe Thr Arg Ser Leu Arg Gly Ser Gln Arg Thr Trp Ala 
225                 230                 235                 240 


Pro Glu Pro Arg 
                


<210>  5295
<211>  204
<212>  PRT
<213>  Homo Sapiens

<400>  5295

Met Gly Ser Pro Arg Ser Ala Leu Ser Cys Leu Leu Leu His Leu Leu 
1               5                   10                  15      


Val Leu Cys Leu Gln Ala Gln His Val Arg Glu Gln Ser Leu Val Thr 
            20                  25                  30          


Asp Gln Leu Ser Arg Arg Leu Ile Arg Thr Tyr Gln Leu Tyr Ser Arg 
        35                  40                  45              


Thr Ser Gly Lys His Val Gln Val Leu Ala Asn Lys Arg Ile Asn Ala 
    50                  55                  60                  


Met Ala Glu Asp Gly Asp Pro Phe Ala Lys Leu Ile Val Glu Thr Asp 
65                  70                  75                  80  


Thr Phe Gly Ser Arg Val Arg Val Arg Gly Ala Glu Thr Gly Leu Tyr 
                85                  90                  95      


Ile Cys Met Asn Lys Lys Gly Lys Leu Ile Ala Lys Ser Asn Gly Lys 
            100                 105                 110         


Gly Lys Asp Cys Val Phe Thr Glu Ile Val Leu Glu Asn Asn Tyr Thr 
        115                 120                 125             


Ala Leu Gln Asn Ala Lys Tyr Glu Gly Trp Tyr Met Ala Phe Thr Arg 
    130                 135                 140                 


Lys Gly Arg Pro Arg Lys Gly Ser Lys Thr Arg Gln His Gln Arg Glu 
145                 150                 155                 160 


Val His Phe Met Lys Arg Leu Pro Arg Gly His His Thr Thr Glu Gln 
                165                 170                 175     


Ser Leu Arg Phe Glu Phe Leu Asn Tyr Pro Pro Phe Thr Arg Ser Leu 
            180                 185                 190         


Arg Gly Ser Gln Arg Thr Trp Ala Pro Glu Pro Arg 
        195                 200                 


<210>  5296
<211>  37
<212>  PRT
<213>  Homo Sapiens

<400>  5296

Met Gly Ser Pro Arg Ser Ala Leu Ser Cys Leu Leu Leu His Leu Leu 
1               5                   10                  15      


Val Leu Cys Leu Gln Ala Gln Val Arg Arg Gly Ala Arg Arg Arg Gly 
            20                  25                  30          


Pro Gly Ala Pro Val 
        35          


<210>  5297
<211>  215
<212>  PRT
<213>  Homo Sapiens

<400>  5297

Met Gly Ser Pro Arg Ser Ala Leu Ser Cys Leu Leu Leu His Leu Leu 
1               5                   10                  15      


Val Leu Cys Leu Gln Ala Gln Val Thr Val Gln Ser Ser Pro Asn Phe 
            20                  25                  30          


Thr Gln His Val Arg Glu Gln Ser Leu Val Thr Asp Gln Leu Ser Arg 
        35                  40                  45              


Arg Leu Ile Arg Thr Tyr Gln Leu Tyr Ser Arg Thr Ser Gly Lys His 
    50                  55                  60                  


Val Gln Val Leu Ala Asn Lys Arg Ile Asn Ala Met Ala Glu Asp Gly 
65                  70                  75                  80  


Asp Pro Phe Ala Lys Leu Ile Val Glu Thr Asp Thr Phe Gly Ser Arg 
                85                  90                  95      


Val Arg Val Arg Gly Ala Glu Thr Gly Leu Tyr Ile Cys Met Asn Lys 
            100                 105                 110         


Lys Gly Lys Leu Ile Ala Lys Ser Asn Gly Lys Gly Lys Asp Cys Val 
        115                 120                 125             


Phe Thr Glu Ile Val Leu Glu Asn Asn Tyr Thr Ala Leu Gln Asn Ala 
    130                 135                 140                 


Lys Tyr Glu Gly Trp Tyr Met Ala Phe Thr Arg Lys Gly Arg Pro Arg 
145                 150                 155                 160 


Lys Gly Ser Lys Thr Arg Gln His Gln Arg Glu Val His Phe Met Lys 
                165                 170                 175     


Arg Leu Pro Arg Gly His His Thr Thr Glu Gln Ser Leu Arg Phe Glu 
            180                 185                 190         


Phe Leu Asn Tyr Pro Pro Phe Thr Arg Ser Leu Arg Gly Ser Gln Arg 
        195                 200                 205             


Thr Trp Ala Pro Glu Pro Arg 
    210                 215 


<210>  5298
<211>  234
<212>  PRT
<213>  Homo Sapiens

<400>  5298

Met Lys Ile Cys Ser Leu Thr Leu Leu Ser Phe Leu Leu Leu Ala Ala 
1               5                   10                  15      


Gln Val Leu Leu Val Glu Gly Lys Lys Lys Val Lys Asn Gly Leu His 
            20                  25                  30          


Ser Lys Val Val Ser Glu Gln Lys Asp Thr Leu Gly Asn Thr Gln Ile 
        35                  40                  45              


Lys Gln Lys Ser Arg Pro Gly Asn Lys Gly Lys Phe Val Thr Lys Asp 
    50                  55                  60                  


Gln Ala Asn Cys Arg Trp Ala Ala Thr Glu Gln Glu Glu Gly Ile Ser 
65                  70                  75                  80  


Leu Lys Val Glu Cys Thr Gln Leu Asp His Glu Phe Ser Cys Val Phe 
                85                  90                  95      


Ala Gly Asn Pro Thr Ser Cys Leu Lys Leu Lys Asp Glu Arg Val Tyr 
            100                 105                 110         


Trp Lys Gln Val Ala Arg Asn Leu Arg Ser Gln Lys Asp Ile Cys Arg 
        115                 120                 125             


Tyr Ser Lys Thr Ala Val Lys Thr Arg Val Cys Arg Lys Asp Phe Pro 
    130                 135                 140                 


Glu Ser Ser Leu Lys Leu Val Ser Ser Thr Leu Phe Gly Asn Thr Lys 
145                 150                 155                 160 


Pro Arg Lys Glu Lys Thr Glu Met Ser Pro Arg Glu His Ile Lys Gly 
                165                 170                 175     


Lys Glu Thr Thr Pro Ser Ser Leu Ala Val Thr Gln Thr Met Ala Thr 
            180                 185                 190         


Lys Ala Pro Glu Cys Val Glu Asp Pro Asp Met Ala Asn Gln Arg Lys 
        195                 200                 205             


Thr Ala Leu Glu Phe Cys Gly Glu Thr Trp Ser Ser Leu Cys Thr Phe 
    210                 215                 220                 


Phe Leu Ser Ile Val Gln Asp Thr Ser Cys 
225                 230                 


<210>  5299
<211>  223
<212>  PRT
<213>  Homo Sapiens

<400>  5299

Met Lys Phe Val Pro Cys Leu Leu Leu Val Thr Leu Ser Cys Leu Gly 
1               5                   10                  15      


Thr Leu Gly Gln Ala Pro Arg Gln Lys Gln Gly Ser Thr Gly Glu Glu 
            20                  25                  30          


Phe His Phe Gln Thr Gly Gly Arg Asp Ser Cys Thr Met Arg Pro Ser 
        35                  40                  45              


Ser Leu Gly Gln Gly Ala Gly Glu Val Trp Leu Arg Val Asp Cys Arg 
    50                  55                  60                  


Asn Thr Asp Gln Thr Tyr Trp Cys Glu Tyr Arg Gly Gln Pro Ser Met 
65                  70                  75                  80  


Cys Gln Ala Phe Ala Ala Asp Pro Lys Pro Tyr Trp Asn Gln Ala Leu 
                85                  90                  95      


Gln Glu Leu Arg Arg Leu His His Ala Cys Gln Gly Ala Pro Val Leu 
            100                 105                 110         


Arg Pro Ser Val Cys Arg Glu Ala Gly Pro Gln Ala His Met Gln Gln 
        115                 120                 125             


Val Thr Ser Ser Leu Lys Gly Ser Pro Glu Pro Asn Gln Gln Pro Glu 
    130                 135                 140                 


Ala Gly Thr Pro Ser Leu Arg Pro Lys Ala Thr Val Lys Leu Thr Glu 
145                 150                 155                 160 


Ala Thr Gln Leu Gly Lys Asp Ser Met Glu Glu Leu Gly Lys Ala Lys 
                165                 170                 175     


Pro Thr Thr Arg Pro Thr Ala Lys Pro Thr Gln Pro Gly Pro Arg Pro 
            180                 185                 190         


Gly Gly Asn Glu Glu Ala Lys Lys Lys Ala Trp Glu His Cys Trp Lys 
        195                 200                 205             


Pro Phe Gln Ala Leu Cys Ala Phe Leu Ile Ser Phe Phe Arg Gly 
    210                 215                 220             


<210>  5300
<211>  258
<212>  PRT
<213>  Homo Sapiens

<400>  5300

Met Thr Pro Pro Lys Leu Arg Ala Ser Leu Ser Pro Ser Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Gly Cys Leu Leu Ala Ala Ala Arg Arg Glu Lys Gly Ala 
            20                  25                  30          


Ala Ser Asn Val Ala Glu Pro Val Pro Gly Pro Thr Gly Gly Ser Ser 
        35                  40                  45              


Gly Arg Phe Leu Ser Pro Glu Gln His Ala Cys Ser Trp Gln Leu Leu 
    50                  55                  60                  


Leu Pro Ala Pro Glu Ala Ala Ala Gly Ser Glu Leu Ala Leu Arg Cys 
65                  70                  75                  80  


Gln Ser Pro Asp Gly Ala Arg His Gln Cys Ala Tyr Arg Gly His Pro 
                85                  90                  95      


Glu Arg Cys Ala Ala Tyr Ala Ala Arg Arg Ala His Phe Trp Lys Gln 
            100                 105                 110         


Val Leu Gly Gly Leu Arg Lys Lys Arg Arg Pro Cys His Asp Pro Ala 
        115                 120                 125             


Pro Leu Gln Ala Arg Leu Cys Ala Gly Lys Lys Gly His Gly Ala Glu 
    130                 135                 140                 


Leu Arg Leu Val Pro Arg Ala Ser Pro Pro Ala Arg Pro Thr Val Ala 
145                 150                 155                 160 


Gly Phe Ala Gly Glu Ser Lys Pro Arg Ala Arg Asn Arg Gly Arg Thr 
                165                 170                 175     


Arg Glu Arg Ala Ser Gly Pro Ala Ala Gly Thr Pro Pro Pro Gln Ser 
            180                 185                 190         


Ala Pro Pro Lys Glu Asn Pro Ser Glu Arg Lys Thr Asn Glu Gly Lys 
        195                 200                 205             


Arg Lys Ala Ala Leu Val Pro Asn Glu Glu Arg Pro Met Gly Thr Gly 
    210                 215                 220                 


Pro Asp Pro Asp Gly Leu Asp Gly Asn Ala Glu Leu Thr Glu Thr Tyr 
225                 230                 235                 240 


Cys Ala Glu Lys Trp His Ser Leu Cys Asn Phe Phe Val Asn Phe Trp 
                245                 250                 255     


Asn Gly 
        


<210>  5301
<211>  812
<212>  PRT
<213>  Homo Sapiens

<400>  5301

Met Ala Ala Val Thr Arg Asp Phe Gly Glu Met Leu Leu His Ser Gly 
1               5                   10                  15      


Arg Val Leu Pro Ala Glu Ala Gln Pro Trp Gly Ala Pro Val Glu Val 
            20                  25                  30          


Glu Ser Phe Leu Val His Pro Gly Asp Leu Leu Gln Leu Arg Cys Arg 
        35                  40                  45              


Leu Arg Asp Asp Val Gln Ser Ile Asn Trp Leu Arg Asp Gly Val Gln 
    50                  55                  60                  


Leu Ala Glu Ser Asn Arg Thr Arg Ile Thr Gly Glu Glu Val Glu Val 
65                  70                  75                  80  


Gln Asp Ser Val Pro Ala Asp Ser Gly Leu Tyr Ala Cys Val Thr Ser 
                85                  90                  95      


Ser Pro Ser Gly Ser Asp Thr Thr Tyr Phe Ser Val Asn Val Ser Asp 
            100                 105                 110         


Ala Leu Pro Ser Ser Glu Asp Asp Asp Asp Asp Asp Asp Ser Ser Ser 
        115                 120                 125             


Glu Glu Lys Glu Thr Asp Asn Thr Lys Pro Asn Arg Met Pro Val Ala 
    130                 135                 140                 


Pro Tyr Trp Thr Ser Pro Glu Lys Met Glu Lys Lys Leu His Ala Val 
145                 150                 155                 160 


Pro Ala Ala Lys Thr Val Lys Phe Lys Cys Pro Ser Ser Gly Thr Pro 
                165                 170                 175     


Asn Pro Thr Leu Arg Trp Leu Lys Asn Gly Lys Glu Phe Lys Pro Asp 
            180                 185                 190         


His Arg Ile Gly Gly Tyr Lys Val Arg Tyr Ala Thr Trp Ser Ile Ile 
        195                 200                 205             


Met Asp Ser Val Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys Ile Val 
    210                 215                 220                 


Glu Asn Glu Tyr Gly Ser Ile Asn His Thr Tyr Gln Leu Asp Val Val 
225                 230                 235                 240 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
                245                 250                 255     


Lys Thr Val Ala Leu Gly Ser Asn Val Glu Phe Met Cys Lys Val Tyr 
            260                 265                 270         


Ser Asp Pro Gln Pro His Ile Gln Trp Leu Lys His Ile Glu Val Asn 
        275                 280                 285             


Gly Ser Lys Ile Gly Pro Asp Asn Leu Pro Tyr Val Gln Ile Leu Lys 
    290                 295                 300                 


Thr Ala Gly Val Asn Thr Thr Asp Lys Glu Met Glu Val Leu His Leu 
305                 310                 315                 320 


Arg Asn Val Ser Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
                325                 330                 335     


Asn Ser Ile Gly Leu Ser His His Ser Ala Trp Leu Thr Val Leu Glu 
            340                 345                 350         


Ala Leu Glu Glu Arg Pro Ala Val Met Thr Ser Pro Leu Tyr Leu Glu 
        355                 360                 365             


Ile Ile Ile Tyr Cys Thr Gly Ala Phe Leu Ile Ser Cys Met Val Gly 
    370                 375                 380                 


Ser Val Ile Val Tyr Lys Met Lys Ser Gly Thr Lys Lys Ser Asp Phe 
385                 390                 395                 400 


His Ser Gln Met Ala Val His Lys Leu Ala Lys Ser Ile Pro Leu Arg 
                405                 410                 415     


Arg Gln Val Ser Ala Asp Ser Ser Ala Ser Met Asn Ser Gly Val Leu 
            420                 425                 430         


Leu Val Arg Pro Ser Arg Leu Ser Ser Ser Gly Thr Pro Met Leu Ala 
        435                 440                 445             


Gly Val Ser Glu Tyr Glu Leu Pro Glu Asp Pro Arg Trp Glu Leu Pro 
    450                 455                 460                 


Arg Asp Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly 
465                 470                 475                 480 


Gln Val Val Leu Ala Glu Ala Ile Gly Leu Asp Lys Asp Lys Pro Asn 
                485                 490                 495     


Arg Val Thr Lys Val Ala Val Lys Met Leu Lys Ser Asp Ala Thr Glu 
            500                 505                 510         


Lys Asp Leu Ser Asp Leu Ile Ser Glu Met Glu Met Met Lys Met Ile 
        515                 520                 525             


Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp 
    530                 535                 540                 


Gly Pro Leu Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg 
545                 550                 555                 560 


Glu Tyr Leu Gln Ala Arg Arg Pro Pro Gly Leu Glu Tyr Cys Tyr Asn 
                565                 570                 575     


Pro Ser His Asn Pro Glu Glu Gln Leu Ser Ser Lys Asp Leu Val Ser 
            580                 585                 590         


Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Lys Lys 
        595                 600                 605             


Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp 
    610                 615                 620                 


Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile His His 
625                 630                 635                 640 


Ile Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp 
                645                 650                 655     


Met Ala Pro Glu Ala Leu Phe Asp Arg Ile Tyr Thr His Gln Ser Asp 
            660                 665                 670         


Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly 
        675                 680                 685             


Ser Pro Tyr Pro Gly Val Pro Val Glu Glu Leu Phe Lys Leu Leu Lys 
    690                 695                 700                 


Glu Gly His Arg Met Asp Lys Pro Ser Asn Cys Thr Asn Glu Leu Tyr 
705                 710                 715                 720 


Met Met Met Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr 
                725                 730                 735     


Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Ile Val Ala Leu Thr Ser 
            740                 745                 750         


Asn Gln Glu Tyr Leu Asp Leu Ser Met Pro Leu Asp Gln Tyr Ser Pro 
        755                 760                 765             


Ser Phe Pro Asp Thr Arg Ser Ser Thr Cys Ser Ser Gly Glu Asp Ser 
    770                 775                 780                 


Val Phe Ser His Glu Pro Leu Pro Glu Glu Pro Cys Leu Pro Arg His 
785                 790                 795                 800 


Pro Ala Gln Leu Ala Asn Gly Gly Leu Lys Arg Arg 
                805                 810         


<210>  5302
<211>  853
<212>  PRT
<213>  Homo Sapiens

<400>  5302

Met Glu Ala Arg Val Ser Leu Lys Arg Arg Ile Glu Leu Thr Val Glu 
1               5                   10                  15      


Tyr Pro Trp Arg Cys Gly Ala Leu Ser Pro Thr Ser Asn Cys Arg Thr 
            20                  25                  30          


Gly Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr 
        35                  40                  45              


Ala Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala 
    50                  55                  60                  


Gln Pro Trp Gly Ala Pro Val Glu Val Glu Ser Phe Leu Val His Pro 
65                  70                  75                  80  


Gly Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser 
                85                  90                  95      


Ile Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Glu Ser Asn Arg Thr 
            100                 105                 110         


Arg Ile Thr Gly Glu Glu Val Glu Val Gln Asp Ser Val Pro Ala Asp 
        115                 120                 125             


Ser Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr 
    130                 135                 140                 


Thr Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp 
145                 150                 155                 160 


Asp Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn 
                165                 170                 175     


Thr Lys Pro Asn Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys Met 
            180                 185                 190         


Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe Lys 
        195                 200                 205             


Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys Asn 
    210                 215                 220                 


Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val Arg 
225                 230                 235                 240 


Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp Lys 
                245                 250                 255     


Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn His 
            260                 265                 270         


Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile Leu 
        275                 280                 285             


Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn Val 
    290                 295                 300                 


Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln Trp 
305                 310                 315                 320 


Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn Leu 
                325                 330                 335     


Pro Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp Lys 
            340                 345                 350         


Glu Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala Gly 
        355                 360                 365             


Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His Ser 
    370                 375                 380                 


Ala Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val Met 
385                 390                 395                 400 


Thr Ser Pro Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr Gly Ala Phe 
                405                 410                 415     


Leu Ile Ser Cys Met Val Gly Ser Val Ile Val Tyr Lys Met Lys Ser 
            420                 425                 430         


Gly Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala Val His Lys Leu 
        435                 440                 445             


Ala Lys Ser Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Asp Ser 
    450                 455                 460                 


Ser Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg Pro Ser Arg Leu 
465                 470                 475                 480 


Ser Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu 
                485                 490                 495     


Pro Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu Val Leu Gly 
            500                 505                 510         


Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Leu Ala Glu Ala 
        515                 520                 525             


Ile Gly Leu Asp Lys Asp Lys Pro Asn Arg Val Thr Lys Val Ala Val 
    530                 535                 540                 


Lys Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Ile 
545                 550                 555                 560 


Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile 
                565                 570                 575     


Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val 
            580                 585                 590         


Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln Ala Arg Arg 
        595                 600                 605             


Pro Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His Asn Pro Glu Glu 
    610                 615                 620                 


Gln Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg 
625                 630                 635                 640 


Gly Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg Asp Leu Ala 
                645                 650                 655     


Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp 
            660                 665                 670         


Phe Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr Lys Lys Thr 
        675                 680                 685             


Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe 
    690                 695                 700                 


Asp Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu 
705                 710                 715                 720 


Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Val Pro 
                725                 730                 735     


Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys 
            740                 745                 750         


Pro Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys Trp 
        755                 760                 765             


His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp 
    770                 775                 780                 


Leu Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr Leu Asp Leu 
785                 790                 795                 800 


Ser Met Pro Leu Asp Gln Tyr Ser Pro Ser Phe Pro Asp Thr Arg Ser 
                805                 810                 815     


Ser Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His Glu Pro Leu 
            820                 825                 830         


Pro Glu Glu Pro Cys Leu Pro Arg His Pro Ala Gln Leu Ala Asn Gly 
        835                 840                 845             


Gly Leu Lys Arg Arg 
    850             


<210>  5303
<211>  139
<212>  PRT
<213>  Homo Sapiens

<400>  5303

Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
1               5                   10                  15      


Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys 
            20                  25                  30          


Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
        35                  40                  45              


Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp 
    50                  55                  60                  


Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn 
65                  70                  75                  80  


His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile 
                85                  90                  95      


Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn 
            100                 105                 110         


Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln 
        115                 120                 125             


Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys 
    130                 135                 


<210>  5304
<211>  61
<212>  PRT
<213>  Homo Sapiens

<400>  5304

Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Cys 
            20                  25                  30          


Pro Asp Leu Gln Glu Ala Lys Trp Cys Ser Ala Ser Phe His Ser Ile 
        35                  40                  45              


Thr Pro Leu Pro Phe Gly Leu Gly Thr Arg Leu Ser Asp 
    50                  55                  60      


<210>  5305
<211>  107
<212>  PRT
<213>  Homo Sapiens

<400>  5305

Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln 
            20                  25                  30          


Pro Trp Gly Ala Pro Val Glu Val Glu Ser Phe Leu Val His Pro Gly 
        35                  40                  45              


Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile 
    50                  55                  60                  


Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg 
65                  70                  75                  80  


Ile Thr Gly Glu Glu Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser 
                85                  90                  95      


Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser 
            100                 105         


<210>  5306
<211>  150
<212>  PRT
<213>  Homo Sapiens

<400>  5306

Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln 
            20                  25                  30          


Pro Trp Gly Ala Pro Val Glu Val Glu Ser Phe Leu Val His Pro Gly 
        35                  40                  45              


Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile 
    50                  55                  60                  


Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg 
65                  70                  75                  80  


Ile Thr Gly Glu Glu Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser 
                85                  90                  95      


Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr 
            100                 105                 110         


Tyr Phe Ser Val Asn Val Ser Ala Cys Pro Asp Leu Gln Glu Ala Lys 
        115                 120                 125             


Trp Cys Ser Ala Ser Phe His Ser Ile Thr Pro Leu Pro Phe Gly Leu 
    130                 135                 140                 


Gly Thr Arg Leu Ser Asp 
145                 150 


<210>  5307
<211>  820
<212>  PRT
<213>  Homo Sapiens

<400>  5307

Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln 
            20                  25                  30          


Pro Trp Gly Ala Pro Val Glu Val Glu Ser Phe Leu Val His Pro Gly 
        35                  40                  45              


Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile 
    50                  55                  60                  


Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg 
65                  70                  75                  80  


Ile Thr Gly Glu Glu Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser 
                85                  90                  95      


Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr 
            100                 105                 110         


Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp 
        115                 120                 125             


Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr 
    130                 135                 140                 


Lys Pro Asn Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys Met Glu 
145                 150                 155                 160 


Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe Lys Cys 
                165                 170                 175     


Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys Asn Gly 
            180                 185                 190         


Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val Arg Tyr 
        195                 200                 205             


Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp Lys Gly 
    210                 215                 220                 


Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn His Thr 
225                 230                 235                 240 


Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile Leu Gln 
                245                 250                 255     


Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn Val Glu 
            260                 265                 270         


Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln Trp Leu 
        275                 280                 285             


Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn Leu Pro 
    290                 295                 300                 


Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp Lys Glu 
305                 310                 315                 320 


Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala Gly Glu 
                325                 330                 335     


Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His Ser Ala 
            340                 345                 350         


Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val Met Thr 
        355                 360                 365             


Ser Pro Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr Gly Ala Phe Leu 
    370                 375                 380                 


Ile Ser Cys Met Val Gly Ser Val Ile Val Tyr Lys Met Lys Ser Gly 
385                 390                 395                 400 


Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala Val His Lys Leu Ala 
                405                 410                 415     


Lys Ser Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Asp Ser Ser 
            420                 425                 430         


Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg Pro Ser Arg Leu Ser 
        435                 440                 445             


Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu Pro 
    450                 455                 460                 


Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu Val Leu Gly Lys 
465                 470                 475                 480 


Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Leu Ala Glu Ala Ile 
                485                 490                 495     


Gly Leu Asp Lys Asp Lys Pro Asn Arg Val Thr Lys Val Ala Val Lys 
            500                 505                 510         


Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Ile Ser 
        515                 520                 525             


Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn 
    530                 535                 540                 


Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val Glu 
545                 550                 555                 560 


Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln Ala Arg Arg Pro 
                565                 570                 575     


Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His Asn Pro Glu Glu Gln 
            580                 585                 590         


Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly 
        595                 600                 605             


Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg Asp Leu Ala Ala 
    610                 615                 620                 


Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe 
625                 630                 635                 640 


Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr Lys Lys Thr Thr 
                645                 650                 655     


Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp 
            660                 665                 670         


Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu 
        675                 680                 685             


Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Val Pro Val 
    690                 695                 700                 


Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro 
705                 710                 715                 720 


Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys Trp His 
                725                 730                 735     


Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu 
            740                 745                 750         


Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr Leu Asp Leu Ser 
        755                 760                 765             


Met Pro Leu Asp Gln Tyr Ser Pro Ser Phe Pro Asp Thr Arg Ser Ser 
    770                 775                 780                 


Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His Glu Pro Leu Pro 
785                 790                 795                 800 


Glu Glu Pro Cys Leu Pro Arg His Pro Ala Gln Leu Ala Asn Gly Gly 
                805                 810                 815     


Leu Lys Arg Arg 
            820 


<210>  5308
<211>  820
<212>  PRT
<213>  Homo Sapiens

<400>  5308

Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln 
            20                  25                  30          


Pro Trp Gly Ala Pro Val Glu Val Glu Ser Phe Leu Val His Pro Gly 
        35                  40                  45              


Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile 
    50                  55                  60                  


Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg 
65                  70                  75                  80  


Ile Thr Gly Glu Glu Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser 
                85                  90                  95      


Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr 
            100                 105                 110         


Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp 
        115                 120                 125             


Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr 
    130                 135                 140                 


Lys Pro Asn Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys Met Glu 
145                 150                 155                 160 


Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe Lys Cys 
                165                 170                 175     


Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys Asn Gly 
            180                 185                 190         


Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val Arg Tyr 
        195                 200                 205             


Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp Lys Gly 
    210                 215                 220                 


Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn His Thr 
225                 230                 235                 240 


Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile Leu Gln 
                245                 250                 255     


Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn Val Glu 
            260                 265                 270         


Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln Trp Leu 
        275                 280                 285             


Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn Leu Pro 
    290                 295                 300                 


Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp Lys Glu 
305                 310                 315                 320 


Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala Gly Glu 
                325                 330                 335     


Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His Ser Ala 
            340                 345                 350         


Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val Met Thr 
        355                 360                 365             


Ser Pro Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr Gly Ala Phe Leu 
    370                 375                 380                 


Ile Ser Cys Met Val Gly Ser Val Ile Val Tyr Lys Met Lys Ser Gly 
385                 390                 395                 400 


Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala Val His Lys Leu Ala 
                405                 410                 415     


Lys Ser Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Asp Ser Ser 
            420                 425                 430         


Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg Pro Ser Arg Leu Ser 
        435                 440                 445             


Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu Pro 
    450                 455                 460                 


Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu Val Leu Gly Lys 
465                 470                 475                 480 


Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Leu Ala Glu Ala Ile 
                485                 490                 495     


Gly Leu Asp Lys Asp Lys Pro Asn Arg Val Thr Lys Val Ala Val Lys 
            500                 505                 510         


Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Ile Ser 
        515                 520                 525             


Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn 
    530                 535                 540                 


Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val Glu 
545                 550                 555                 560 


Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln Ala Arg Arg Pro 
                565                 570                 575     


Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His Asn Pro Glu Glu Gln 
            580                 585                 590         


Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly 
        595                 600                 605             


Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg Asp Leu Ala Ala 
    610                 615                 620                 


Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe 
625                 630                 635                 640 


Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr Lys Lys Thr Thr 
                645                 650                 655     


Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp 
            660                 665                 670         


Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu 
        675                 680                 685             


Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Val Pro Val 
    690                 695                 700                 


Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro 
705                 710                 715                 720 


Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys Trp His 
                725                 730                 735     


Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu 
            740                 745                 750         


Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr Leu Asp Leu Ser 
        755                 760                 765             


Met Pro Leu Asp Gln Tyr Ser Pro Ser Phe Pro Asp Thr Arg Ser Ser 
    770                 775                 780                 


Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His Glu Pro Leu Pro 
785                 790                 795                 800 


Glu Glu Pro Cys Leu Pro Arg His Pro Ala Gln Leu Ala Asn Gly Gly 
                805                 810                 815     


Leu Lys Arg Arg 
            820 


<210>  5309
<211>  820
<212>  PRT
<213>  Homo Sapiens

<400>  5309

Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln 
            20                  25                  30          


Pro Trp Gly Ala Pro Val Glu Val Glu Ser Phe Leu Val His Pro Gly 
        35                  40                  45              


Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile 
    50                  55                  60                  


Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg 
65                  70                  75                  80  


Ile Thr Gly Glu Glu Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser 
                85                  90                  95      


Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr 
            100                 105                 110         


Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp 
        115                 120                 125             


Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr 
    130                 135                 140                 


Lys Pro Asn Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys Met Glu 
145                 150                 155                 160 


Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe Lys Cys 
                165                 170                 175     


Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys Asn Gly 
            180                 185                 190         


Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val Arg Tyr 
        195                 200                 205             


Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp Lys Gly 
    210                 215                 220                 


Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn His Thr 
225                 230                 235                 240 


Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile Leu Gln 
                245                 250                 255     


Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn Val Glu 
            260                 265                 270         


Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln Trp Leu 
        275                 280                 285             


Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn Leu Pro 
    290                 295                 300                 


Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp Lys Glu 
305                 310                 315                 320 


Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala Gly Glu 
                325                 330                 335     


Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His Ser Ala 
            340                 345                 350         


Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val Met Thr 
        355                 360                 365             


Ser Pro Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr Gly Ala Phe Leu 
    370                 375                 380                 


Ile Ser Cys Met Val Gly Ser Val Ile Val Tyr Lys Met Lys Ser Gly 
385                 390                 395                 400 


Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala Val His Lys Leu Ala 
                405                 410                 415     


Lys Ser Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Asp Ser Ser 
            420                 425                 430         


Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg Pro Ser Arg Leu Ser 
        435                 440                 445             


Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu Pro 
    450                 455                 460                 


Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu Val Leu Gly Lys 
465                 470                 475                 480 


Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Leu Ala Glu Ala Ile 
                485                 490                 495     


Gly Leu Asp Lys Asp Lys Pro Asn Arg Val Thr Lys Val Ala Val Lys 
            500                 505                 510         


Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Ile Ser 
        515                 520                 525             


Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn 
    530                 535                 540                 


Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val Glu 
545                 550                 555                 560 


Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln Ala Arg Arg Pro 
                565                 570                 575     


Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His Asn Pro Glu Glu Gln 
            580                 585                 590         


Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly 
        595                 600                 605             


Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg Asp Leu Ala Ala 
    610                 615                 620                 


Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe 
625                 630                 635                 640 


Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr Lys Lys Thr Thr 
                645                 650                 655     


Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp 
            660                 665                 670         


Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu 
        675                 680                 685             


Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Val Pro Val 
    690                 695                 700                 


Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro 
705                 710                 715                 720 


Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys Trp His 
                725                 730                 735     


Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu 
            740                 745                 750         


Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr Leu Asp Leu Ser 
        755                 760                 765             


Met Pro Leu Asp Gln Tyr Ser Pro Ser Phe Pro Asp Thr Arg Ser Ser 
    770                 775                 780                 


Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His Glu Pro Leu Pro 
785                 790                 795                 800 


Glu Glu Pro Cys Leu Pro Arg His Pro Ala Gln Leu Ala Asn Gly Gly 
                805                 810                 815     


Leu Lys Arg Arg 
            820 


<210>  5310
<211>  822
<212>  PRT
<213>  Homo Sapiens

<400>  5310

Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln 
            20                  25                  30          


Pro Trp Gly Ala Pro Val Glu Val Glu Ser Phe Leu Val His Pro Gly 
        35                  40                  45              


Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile 
    50                  55                  60                  


Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg 
65                  70                  75                  80  


Ile Thr Gly Glu Glu Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser 
                85                  90                  95      


Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr 
            100                 105                 110         


Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp 
        115                 120                 125             


Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr 
    130                 135                 140                 


Lys Pro Asn Arg Met Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys 
145                 150                 155                 160 


Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
                165                 170                 175     


Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys 
            180                 185                 190         


Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
        195                 200                 205             


Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp 
    210                 215                 220                 


Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn 
225                 230                 235                 240 


His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile 
                245                 250                 255     


Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn 
            260                 265                 270         


Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln 
        275                 280                 285             


Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn 
    290                 295                 300                 


Leu Pro Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp 
305                 310                 315                 320 


Lys Glu Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala 
                325                 330                 335     


Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His 
            340                 345                 350         


Ser Ala Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val 
        355                 360                 365             


Met Thr Ser Pro Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr Gly Ala 
    370                 375                 380                 


Phe Leu Ile Ser Cys Met Val Gly Ser Val Ile Val Tyr Lys Met Lys 
385                 390                 395                 400 


Ser Gly Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala Val His Lys 
                405                 410                 415     


Leu Ala Lys Ser Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Asp 
            420                 425                 430         


Ser Ser Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg Pro Ser Arg 
        435                 440                 445             


Leu Ser Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu 
    450                 455                 460                 


Leu Pro Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu Val Leu 
465                 470                 475                 480 


Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Leu Ala Glu 
                485                 490                 495     


Ala Ile Gly Leu Asp Lys Asp Lys Pro Asn Arg Val Thr Lys Val Ala 
            500                 505                 510         


Val Lys Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu 
        515                 520                 525             


Ile Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile 
    530                 535                 540                 


Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile 
545                 550                 555                 560 


Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln Ala Arg 
                565                 570                 575     


Arg Pro Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His Asn Pro Glu 
            580                 585                 590         


Glu Gln Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala 
        595                 600                 605             


Arg Gly Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg Asp Leu 
    610                 615                 620                 


Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala 
625                 630                 635                 640 


Asp Phe Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr Lys Lys 
                645                 650                 655     


Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu 
            660                 665                 670         


Phe Asp Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val 
        675                 680                 685             


Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Val 
    690                 695                 700                 


Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp 
705                 710                 715                 720 


Lys Pro Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys 
                725                 730                 735     


Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu 
            740                 745                 750         


Asp Leu Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr Leu Asp 
        755                 760                 765             


Leu Ser Met Pro Leu Asp Gln Tyr Ser Pro Ser Phe Pro Asp Thr Arg 
    770                 775                 780                 


Ser Ser Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His Glu Pro 
785                 790                 795                 800 


Leu Pro Glu Glu Pro Cys Leu Pro Arg His Pro Ala Gln Leu Ala Asn 
                805                 810                 815     


Gly Gly Leu Lys Arg Arg 
            820         


<210>  5311
<211>  298
<212>  PRT
<213>  Homo Sapiens

<400>  5311

Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln 
            20                  25                  30          


Pro Trp Gly Ala Pro Val Glu Val Glu Ser Phe Leu Val His Pro Gly 
        35                  40                  45              


Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile 
    50                  55                  60                  


Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg 
65                  70                  75                  80  


Ile Thr Gly Glu Glu Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser 
                85                  90                  95      


Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr 
            100                 105                 110         


Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp 
        115                 120                 125             


Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr 
    130                 135                 140                 


Lys Pro Asn Arg Met Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys 
145                 150                 155                 160 


Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
                165                 170                 175     


Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys 
            180                 185                 190         


Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
        195                 200                 205             


Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp 
    210                 215                 220                 


Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn 
225                 230                 235                 240 


His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile 
                245                 250                 255     


Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn 
            260                 265                 270         


Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln 
        275                 280                 285             


Trp Leu Lys His Ile Glu Val Asn Gly Ser 
    290                 295             


<210>  5312
<211>  820
<212>  PRT
<213>  Homo Sapiens

<400>  5312

Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln 
            20                  25                  30          


Pro Trp Gly Ala Pro Val Glu Val Glu Ser Phe Leu Val His Pro Gly 
        35                  40                  45              


Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile 
    50                  55                  60                  


Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg 
65                  70                  75                  80  


Ile Thr Gly Glu Glu Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser 
                85                  90                  95      


Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr 
            100                 105                 110         


Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp 
        115                 120                 125             


Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr 
    130                 135                 140                 


Lys Pro Asn Arg Met Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys 
145                 150                 155                 160 


Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
                165                 170                 175     


Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys 
            180                 185                 190         


Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
        195                 200                 205             


Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp 
    210                 215                 220                 


Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn 
225                 230                 235                 240 


His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile 
                245                 250                 255     


Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn 
            260                 265                 270         


Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln 
        275                 280                 285             


Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn 
    290                 295                 300                 


Leu Pro Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp 
305                 310                 315                 320 


Lys Glu Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala 
                325                 330                 335     


Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His 
            340                 345                 350         


Ser Ala Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val 
        355                 360                 365             


Met Thr Ser Pro Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr Gly Ala 
    370                 375                 380                 


Phe Leu Ile Ser Cys Met Val Gly Ser Val Ile Val Tyr Lys Met Lys 
385                 390                 395                 400 


Ser Gly Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala Val His Lys 
                405                 410                 415     


Leu Ala Lys Ser Ile Pro Leu Arg Arg Gln Val Ser Ala Asp Ser Ser 
            420                 425                 430         


Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg Pro Ser Arg Leu Ser 
        435                 440                 445             


Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu Pro 
    450                 455                 460                 


Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu Val Leu Gly Lys 
465                 470                 475                 480 


Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Leu Ala Glu Ala Ile 
                485                 490                 495     


Gly Leu Asp Lys Asp Lys Pro Asn Arg Val Thr Lys Val Ala Val Lys 
            500                 505                 510         


Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Ile Ser 
        515                 520                 525             


Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn 
    530                 535                 540                 


Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val Glu 
545                 550                 555                 560 


Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln Ala Arg Arg Pro 
                565                 570                 575     


Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His Asn Pro Glu Glu Gln 
            580                 585                 590         


Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly 
        595                 600                 605             


Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg Asp Leu Ala Ala 
    610                 615                 620                 


Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe 
625                 630                 635                 640 


Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr Lys Lys Thr Thr 
                645                 650                 655     


Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp 
            660                 665                 670         


Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu 
        675                 680                 685             


Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Val Pro Val 
    690                 695                 700                 


Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro 
705                 710                 715                 720 


Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys Trp His 
                725                 730                 735     


Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu 
            740                 745                 750         


Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr Leu Asp Leu Ser 
        755                 760                 765             


Met Pro Leu Asp Gln Tyr Ser Pro Ser Phe Pro Asp Thr Arg Ser Ser 
    770                 775                 780                 


Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His Glu Pro Leu Pro 
785                 790                 795                 800 


Glu Glu Pro Cys Leu Pro Arg His Pro Ala Gln Leu Ala Asn Gly Gly 
                805                 810                 815     


Leu Lys Arg Arg 
            820 


<210>  5313
<211>  367
<212>  PRT
<213>  Homo Sapiens

<400>  5313

Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln 
            20                  25                  30          


Pro Trp Gly Ala Pro Val Glu Val Glu Ser Phe Leu Val His Pro Gly 
        35                  40                  45              


Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile 
    50                  55                  60                  


Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg 
65                  70                  75                  80  


Ile Thr Gly Glu Glu Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser 
                85                  90                  95      


Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr 
            100                 105                 110         


Tyr Phe Ser Val Asn Val Ser Val Pro Ile Asp Ala Leu Pro Ser Ser 
        115                 120                 125             


Glu Asp Asp Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr 
    130                 135                 140                 


Asp Asn Thr Lys Pro Asn Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu 
145                 150                 155                 160 


Lys Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys 
                165                 170                 175     


Phe Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu 
            180                 185                 190         


Lys Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys 
        195                 200                 205             


Val Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser 
    210                 215                 220                 


Asp Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile 
225                 230                 235                 240 


Asn His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro 
                245                 250                 255     


Ile Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser 
            260                 265                 270         


Asn Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile 
        275                 280                 285             


Gln Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp 
    290                 295                 300                 


Asn Leu Pro Tyr Val Gln Ile Leu Lys His Ser Gly Ile Asn Ser Ser 
305                 310                 315                 320 


Asp Ala Glu Val Leu Thr Leu Phe Asn Val Thr Glu Ala Gln Ser Gly 
                325                 330                 335     


Glu Tyr Val Cys Lys Val Ser Asn Tyr Ile Gly Glu Ala Asn Gln Ser 
            340                 345                 350         


Ala Trp Leu Thr Val Thr Arg Pro Val Ala Lys Asp Cys Trp Ser 
        355                 360                 365         


<210>  5314
<211>  55
<212>  PRT
<213>  Homo Sapiens

<400>  5314

Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Asp Ala 
            20                  25                  30          


Leu Pro Ser Ser Glu Asp Asp Asp Asp Asp Asp Asp Ser Ser Ser Glu 
        35                  40                  45              


Glu Lys Glu Thr Asp Asn Thr 
    50                  55  


<210>  5315
<211>  85
<212>  PRT
<213>  Homo Sapiens

<400>  5315

Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Asp Ala 
            20                  25                  30          


Leu Pro Ser Ser Glu Asp Asp Asp Asp Asp Asp Asp Ser Ser Ser Glu 
        35                  40                  45              


Glu Lys Glu Thr Asp Asn Thr Lys Pro Asn Pro Val Ala Pro Tyr Trp 
    50                  55                  60                  


Thr Ser Pro Glu Lys Met Glu Lys Lys Leu His Ala Val Pro Ala Ala 
65                  70                  75                  80  


Lys Thr Val Lys Phe 
                85  


<210>  5316
<211>  145
<212>  PRT
<213>  Homo Sapiens

<400>  5316

Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Asp Ala 
            20                  25                  30          


Leu Pro Ser Ser Glu Asp Asp Asp Asp Asp Asp Asp Ser Ser Ser Glu 
        35                  40                  45              


Glu Lys Glu Thr Asp Asn Thr Lys Pro Asn Pro Val Ala Pro Tyr Trp 
    50                  55                  60                  


Thr Ser Pro Glu Lys Met Glu Lys Lys Leu His Ala Val Pro Ala Ala 
65                  70                  75                  80  


Lys Thr Val Lys Phe Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr 
                85                  90                  95      


Leu Arg Trp Leu Lys Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile 
            100                 105                 110         


Gly Gly Tyr Lys Val Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser 
        115                 120                 125             


Val Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu 
    130                 135                 140                 


Tyr 
145 


<210>  5317
<211>  733
<212>  PRT
<213>  Homo Sapiens

<400>  5317

Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Asp Ala 
            20                  25                  30          


Leu Pro Ser Ser Glu Asp Asp Asp Asp Asp Asp Asp Ser Ser Ser Glu 
        35                  40                  45              


Glu Lys Glu Thr Asp Asn Thr Lys Pro Asn Pro Val Ala Pro Tyr Trp 
    50                  55                  60                  


Thr Ser Pro Glu Lys Met Glu Lys Lys Leu His Ala Val Pro Ala Ala 
65                  70                  75                  80  


Lys Thr Val Lys Phe Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr 
                85                  90                  95      


Leu Arg Trp Leu Lys Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile 
            100                 105                 110         


Gly Gly Tyr Lys Val Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser 
        115                 120                 125             


Val Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu 
    130                 135                 140                 


Tyr Gly Ser Ile Asn His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser 
145                 150                 155                 160 


Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val 
                165                 170                 175     


Ala Leu Gly Ser Asn Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro 
            180                 185                 190         


Gln Pro His Ile Gln Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys 
        195                 200                 205             


Ile Gly Pro Asp Asn Leu Pro Tyr Val Gln Ile Leu Lys His Ser Gly 
    210                 215                 220                 


Ile Asn Ser Ser Asp Ala Glu Val Leu Thr Leu Phe Asn Val Thr Glu 
225                 230                 235                 240 


Ala Gln Ser Gly Glu Tyr Val Cys Lys Val Ser Asn Tyr Ile Gly Glu 
                245                 250                 255     


Ala Asn Gln Ser Ala Trp Leu Thr Val Thr Arg Pro Val Ala Lys Ala 
            260                 265                 270         


Leu Glu Glu Arg Pro Ala Val Met Thr Ser Pro Leu Tyr Leu Glu Ile 
        275                 280                 285             


Ile Ile Tyr Cys Thr Gly Ala Phe Leu Ile Ser Cys Met Val Gly Ser 
    290                 295                 300                 


Val Ile Val Tyr Lys Met Lys Ser Gly Thr Lys Lys Ser Asp Phe His 
305                 310                 315                 320 


Ser Gln Met Ala Val His Lys Leu Ala Lys Ser Ile Pro Leu Arg Arg 
                325                 330                 335     


Gln Val Thr Val Ser Ala Asp Ser Ser Ala Ser Met Asn Ser Gly Val 
            340                 345                 350         


Leu Leu Val Arg Pro Ser Arg Leu Ser Ser Ser Gly Thr Pro Met Leu 
        355                 360                 365             


Ala Gly Val Ser Glu Tyr Glu Leu Pro Glu Asp Pro Arg Trp Glu Leu 
    370                 375                 380                 


Pro Arg Asp Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe 
385                 390                 395                 400 


Gly Gln Val Val Leu Ala Glu Ala Ile Gly Leu Asp Lys Asp Lys Pro 
                405                 410                 415     


Asn Arg Val Thr Lys Val Ala Val Lys Met Leu Lys Ser Asp Ala Thr 
            420                 425                 430         


Glu Lys Asp Leu Ser Asp Leu Ile Ser Glu Met Glu Met Met Lys Met 
        435                 440                 445             


Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln 
    450                 455                 460                 


Asp Gly Pro Leu Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu 
465                 470                 475                 480 


Arg Glu Tyr Leu Gln Ala Arg Arg Pro Pro Gly Leu Glu Tyr Cys Tyr 
                485                 490                 495     


Asn Pro Ser His Asn Pro Glu Glu Gln Leu Ser Ser Lys Asp Leu Val 
            500                 505                 510         


Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Lys 
        515                 520                 525             


Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu 
    530                 535                 540                 


Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile His 
545                 550                 555                 560 


His Ile Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys 
                565                 570                 575     


Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Ile Tyr Thr His Gln Ser 
            580                 585                 590         


Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Thr Leu Gly 
        595                 600                 605             


Gly Ser Pro Tyr Pro Gly Val Pro Val Glu Glu Leu Phe Lys Leu Leu 
    610                 615                 620                 


Lys Glu Gly His Arg Met Asp Lys Pro Ser Asn Cys Thr Asn Glu Leu 
625                 630                 635                 640 


Tyr Met Met Met Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro 
                645                 650                 655     


Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Ile Val Ala Leu Thr 
            660                 665                 670         


Ser Asn Gln Glu Tyr Leu Asp Leu Ser Met Pro Leu Asp Gln Tyr Ser 
        675                 680                 685             


Pro Ser Phe Pro Asp Thr Arg Ser Ser Thr Cys Ser Ser Gly Glu Asp 
    690                 695                 700                 


Ser Val Phe Ser His Glu Pro Leu Pro Glu Glu Pro Cys Leu Pro Arg 
705                 710                 715                 720 


His Pro Ala Gln Leu Ala Asn Gly Gly Leu Lys Arg Arg 
                725                 730             


<210>  5318
<211>  228
<212>  PRT
<213>  Homo Sapiens

<400>  5318

Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Asp Ala 
            20                  25                  30          


Leu Pro Ser Ser Glu Asp Asp Asp Asp Asp Asp Asp Ser Ser Ser Glu 
        35                  40                  45              


Glu Lys Glu Thr Asp Asn Thr Lys Pro Asn Pro Val Ala Pro Tyr Trp 
    50                  55                  60                  


Thr Ser Pro Glu Lys Met Glu Lys Lys Leu His Ala Val Pro Ala Ala 
65                  70                  75                  80  


Lys Thr Val Lys Phe Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr 
                85                  90                  95      


Leu Arg Trp Leu Lys Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile 
            100                 105                 110         


Gly Gly Tyr Lys Val Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser 
        115                 120                 125             


Val Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu 
    130                 135                 140                 


Tyr Gly Ser Ile Asn His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser 
145                 150                 155                 160 


Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val 
                165                 170                 175     


Ala Leu Gly Ser Asn Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro 
            180                 185                 190         


Gln Pro His Ile Gln Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys 
        195                 200                 205             


Ile Gly Pro Asp Asn Leu Pro Tyr Val Gln Ile Leu Lys Pro Trp Lys 
    210                 215                 220                 


Arg Gly Arg Gln 
225             


<210>  5319
<211>  731
<212>  PRT
<213>  Homo Sapiens

<400>  5319

Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Asp Ala 
            20                  25                  30          


Leu Pro Ser Ser Glu Asp Asp Asp Asp Asp Asp Asp Ser Ser Ser Glu 
        35                  40                  45              


Glu Lys Glu Thr Asp Asn Thr Lys Pro Asn Pro Val Ala Pro Tyr Trp 
    50                  55                  60                  


Thr Ser Pro Glu Lys Met Glu Lys Lys Leu His Ala Val Pro Ala Ala 
65                  70                  75                  80  


Lys Thr Val Lys Phe Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr 
                85                  90                  95      


Leu Arg Trp Leu Lys Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile 
            100                 105                 110         


Gly Gly Tyr Lys Val Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser 
        115                 120                 125             


Val Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu 
    130                 135                 140                 


Tyr Gly Ser Ile Asn His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser 
145                 150                 155                 160 


Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val 
                165                 170                 175     


Ala Leu Gly Ser Asn Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro 
            180                 185                 190         


Gln Pro His Ile Gln Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys 
        195                 200                 205             


Ile Gly Pro Asp Asn Leu Pro Tyr Val Gln Ile Leu Lys Thr Ala Gly 
    210                 215                 220                 


Val Asn Thr Thr Asp Lys Glu Met Glu Val Leu His Leu Arg Asn Val 
225                 230                 235                 240 


Ser Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile 
                245                 250                 255     


Gly Leu Ser His His Ser Ala Trp Leu Thr Val Leu Glu Ala Leu Glu 
            260                 265                 270         


Glu Arg Pro Ala Val Met Thr Ser Pro Leu Tyr Leu Glu Ile Ile Ile 
        275                 280                 285             


Tyr Cys Thr Gly Ala Phe Leu Ile Ser Cys Met Val Gly Ser Val Ile 
    290                 295                 300                 


Val Tyr Lys Met Lys Ser Gly Thr Lys Lys Ser Asp Phe His Ser Gln 
305                 310                 315                 320 


Met Ala Val His Lys Leu Ala Lys Ser Ile Pro Leu Arg Arg Gln Val 
                325                 330                 335     


Thr Val Ser Ala Asp Ser Ser Ala Ser Met Asn Ser Gly Val Leu Leu 
            340                 345                 350         


Val Arg Pro Ser Arg Leu Ser Ser Ser Gly Thr Pro Met Leu Ala Gly 
        355                 360                 365             


Val Ser Glu Tyr Glu Leu Pro Glu Asp Pro Arg Trp Glu Leu Pro Arg 
    370                 375                 380                 


Asp Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln 
385                 390                 395                 400 


Val Val Leu Ala Glu Ala Ile Gly Leu Asp Lys Asp Lys Pro Asn Arg 
                405                 410                 415     


Val Thr Lys Val Ala Val Lys Met Leu Lys Ser Asp Ala Thr Glu Lys 
            420                 425                 430         


Asp Leu Ser Asp Leu Ile Ser Glu Met Glu Met Met Lys Met Ile Gly 
        435                 440                 445             


Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly 
    450                 455                 460                 


Pro Leu Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu 
465                 470                 475                 480 


Tyr Leu Gln Ala Arg Arg Pro Pro Gly Leu Glu Tyr Cys Tyr Asn Pro 
                485                 490                 495     


Ser His Asn Pro Glu Glu Gln Leu Ser Ser Lys Asp Leu Val Ser Cys 
            500                 505                 510         


Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Lys Lys Cys 
        515                 520                 525             


Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn 
    530                 535                 540                 


Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile His His Ile 
545                 550                 555                 560 


Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met 
                565                 570                 575     


Ala Pro Glu Ala Leu Phe Asp Arg Ile Tyr Thr His Gln Ser Asp Val 
            580                 585                 590         


Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser 
        595                 600                 605             


Pro Tyr Pro Gly Val Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu 
    610                 615                 620                 


Gly His Arg Met Asp Lys Pro Ser Asn Cys Thr Asn Glu Leu Tyr Met 
625                 630                 635                 640 


Met Met Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe 
                645                 650                 655     


Lys Gln Leu Val Glu Asp Leu Asp Arg Ile Val Ala Leu Thr Ser Asn 
            660                 665                 670         


Gln Glu Tyr Leu Asp Leu Ser Met Pro Leu Asp Gln Tyr Ser Pro Ser 
        675                 680                 685             


Phe Pro Asp Thr Arg Ser Ser Thr Cys Ser Ser Gly Glu Asp Ser Val 
    690                 695                 700                 


Phe Ser His Glu Pro Leu Pro Glu Glu Pro Cys Leu Pro Arg His Pro 
705                 710                 715                 720 


Ala Gln Leu Ala Asn Gly Gly Leu Lys Arg Arg 
                725                 730     


<210>  5320
<211>  142
<212>  PRT
<213>  Homo Sapiens

<400>  5320

Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Asp Ala 
            20                  25                  30          


Leu Pro Ser Ser Glu Asp Asp Asp Asp Asp Asp Asp Ser Ser Ser Glu 
        35                  40                  45              


Glu Lys Glu Thr Asp Asn Thr Lys Pro Asn Arg Met Pro Val Ala Pro 
    50                  55                  60                  


Tyr Trp Thr Ser Pro Glu Lys Met Glu Lys Lys Leu His Ala Val Pro 
65                  70                  75                  80  


Ala Ala Lys Thr Val Lys Phe Lys Cys Pro Ser Ser Gly Thr Pro Asn 
                85                  90                  95      


Pro Thr Leu Arg Trp Leu Lys Asn Gly Lys Glu Phe Lys Pro Asp His 
            100                 105                 110         


Arg Ile Gly Gly Tyr Lys Val Arg Tyr Ala Thr Trp Ser Ile Ile Met 
        115                 120                 125             


Asp Ser Val Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys Ile 
    130                 135                 140         


<210>  5321
<211>  733
<212>  PRT
<213>  Homo Sapiens

<400>  5321

Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Asp Ala 
            20                  25                  30          


Leu Pro Ser Ser Glu Asp Asp Asp Asp Asp Asp Asp Ser Ser Ser Glu 
        35                  40                  45              


Glu Lys Glu Thr Asp Asn Thr Lys Pro Asn Arg Met Pro Val Ala Pro 
    50                  55                  60                  


Tyr Trp Thr Ser Pro Glu Lys Met Glu Lys Lys Leu His Ala Val Pro 
65                  70                  75                  80  


Ala Ala Lys Thr Val Lys Phe Lys Cys Pro Ser Ser Gly Thr Pro Asn 
                85                  90                  95      


Pro Thr Leu Arg Trp Leu Lys Asn Gly Lys Glu Phe Lys Pro Asp His 
            100                 105                 110         


Arg Ile Gly Gly Tyr Lys Val Arg Tyr Ala Thr Trp Ser Ile Ile Met 
        115                 120                 125             


Asp Ser Val Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys Ile Val Glu 
    130                 135                 140                 


Asn Glu Tyr Gly Ser Ile Asn His Thr Tyr Gln Leu Asp Val Val Glu 
145                 150                 155                 160 


Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Lys 
                165                 170                 175     


Thr Val Ala Leu Gly Ser Asn Val Glu Phe Met Cys Lys Val Tyr Ser 
            180                 185                 190         


Asp Pro Gln Pro His Ile Gln Trp Leu Lys His Ile Glu Val Asn Gly 
        195                 200                 205             


Ser Lys Ile Gly Pro Asp Asn Leu Pro Tyr Val Gln Ile Leu Lys Thr 
    210                 215                 220                 


Ala Gly Val Asn Thr Thr Asp Lys Glu Met Glu Val Leu His Leu Arg 
225                 230                 235                 240 


Asn Val Ser Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn 
                245                 250                 255     


Ser Ile Gly Leu Ser His His Ser Ala Trp Leu Thr Val Leu Glu Ala 
            260                 265                 270         


Leu Glu Glu Arg Pro Ala Val Met Thr Ser Pro Leu Tyr Leu Glu Ile 
        275                 280                 285             


Ile Ile Tyr Cys Thr Gly Ala Phe Leu Ile Ser Cys Met Val Gly Ser 
    290                 295                 300                 


Val Ile Val Tyr Lys Met Lys Ser Gly Thr Lys Lys Ser Asp Phe His 
305                 310                 315                 320 


Ser Gln Met Ala Val His Lys Leu Ala Lys Ser Ile Pro Leu Arg Arg 
                325                 330                 335     


Gln Val Thr Val Ser Ala Asp Ser Ser Ala Ser Met Asn Ser Gly Val 
            340                 345                 350         


Leu Leu Val Arg Pro Ser Arg Leu Ser Ser Ser Gly Thr Pro Met Leu 
        355                 360                 365             


Ala Gly Val Ser Glu Tyr Glu Leu Pro Glu Asp Pro Arg Trp Glu Leu 
    370                 375                 380                 


Pro Arg Asp Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe 
385                 390                 395                 400 


Gly Gln Val Val Leu Ala Glu Ala Ile Gly Leu Asp Lys Asp Lys Pro 
                405                 410                 415     


Asn Arg Val Thr Lys Val Ala Val Lys Met Leu Lys Ser Asp Ala Thr 
            420                 425                 430         


Glu Lys Asp Leu Ser Asp Leu Ile Ser Glu Met Glu Met Met Lys Met 
        435                 440                 445             


Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln 
    450                 455                 460                 


Asp Gly Pro Leu Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu 
465                 470                 475                 480 


Arg Glu Tyr Leu Gln Ala Arg Arg Pro Pro Gly Leu Glu Tyr Cys Tyr 
                485                 490                 495     


Asn Pro Ser His Asn Pro Glu Glu Gln Leu Ser Ser Lys Asp Leu Val 
            500                 505                 510         


Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Lys 
        515                 520                 525             


Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu 
    530                 535                 540                 


Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile His 
545                 550                 555                 560 


His Ile Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys 
                565                 570                 575     


Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Ile Tyr Thr His Gln Ser 
            580                 585                 590         


Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Thr Leu Gly 
        595                 600                 605             


Gly Ser Pro Tyr Pro Gly Val Pro Val Glu Glu Leu Phe Lys Leu Leu 
    610                 615                 620                 


Lys Glu Gly His Arg Met Asp Lys Pro Ser Asn Cys Thr Asn Glu Leu 
625                 630                 635                 640 


Tyr Met Met Met Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro 
                645                 650                 655     


Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Ile Val Ala Leu Thr 
            660                 665                 670         


Ser Asn Gln Glu Tyr Leu Asp Leu Ser Met Pro Leu Asp Gln Tyr Ser 
        675                 680                 685             


Pro Ser Phe Pro Asp Thr Arg Ser Ser Thr Cys Ser Ser Gly Glu Asp 
    690                 695                 700                 


Ser Val Phe Ser His Glu Pro Leu Pro Glu Glu Pro Cys Leu Pro Arg 
705                 710                 715                 720 


His Pro Ala Gln Leu Ala Asn Gly Gly Leu Lys Arg Arg 
                725                 730             


<210>  5322
<211>  134
<212>  PRT
<213>  Homo Sapiens

<400>  5322

Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu Ala Ser 
1               5                   10                  15      


Lys Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr 
            20                  25                  30          


Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile 
        35                  40                  45              


His His Ile Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val 
    50                  55                  60                  


Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Ile Tyr Thr His Gln 
65                  70                  75                  80  


Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Thr Leu 
                85                  90                  95      


Gly Gly Ser Pro Tyr Pro Gly Val Pro Val Glu Glu Leu Phe Lys Leu 
            100                 105                 110         


Leu Lys Glu Gly His Arg Met Asp Lys Pro Ser Asn Cys Thr Asn Glu 
        115                 120                 125             


Leu Pro Ala Ala Gly Thr 
    130                 


<210>  5323
<211>  371
<212>  PRT
<213>  Homo Sapiens

<400>  5323

Phe Ser Ser Gln Pro Ala Val His Lys Leu Thr Lys Arg Ile Pro Leu 
1               5                   10                  15      


Arg Arg Gln Val Thr Val Ser Ala Glu Ser Ser Ser Ser Met Asn Ser 
            20                  25                  30          


Asn Thr Pro Leu Val Arg Ile Thr Thr Arg Leu Ser Ser Thr Ala Asp 
        35                  40                  45              


Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu Pro Glu Asp Pro 
    50                  55                  60                  


Lys Trp Glu Phe Pro Arg Asp Lys Leu Thr Leu Gly Lys Pro Leu Gly 
65                  70                  75                  80  


Glu Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Val Gly Ile Asp 
                85                  90                  95      


Lys Asp Lys Pro Lys Glu Ala Val Thr Val Ala Val Lys Met Leu Lys 
            100                 105                 110         


Asp Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu 
        115                 120                 125             


Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly 
    130                 135                 140                 


Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val Glu Tyr Ala Ser 
145                 150                 155                 160 


Lys Gly Asn Leu Arg Glu Tyr Leu Arg Ala Arg Arg Pro Pro Gly Met 
                165                 170                 175     


Glu Tyr Ser Tyr Asp Ile Asn Arg Val Pro Glu Glu Gln Met Thr Phe 
            180                 185                 190         


Lys Asp Leu Val Ser Cys Thr Tyr Gln Leu Ala Arg Gly Met Glu Tyr 
        195                 200                 205             


Leu Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val 
    210                 215                 220                 


Leu Val Thr Glu Asn Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala 
225                 230                 235                 240 


Arg Asp Ile Asn Asn Ile Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg 
                245                 250                 255     


Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr 
            260                 265                 270         


Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Met Trp Glu Ile 
        275                 280                 285             


Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu 
    290                 295                 300                 


Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys 
305                 310                 315                 320 


Thr Asn Glu Leu Asn Thr Trp Thr Ser Ala Asn Leu Ser Asn Ser Ile 
                325                 330                 335     


His Leu Val Thr Leu Thr Gln Glu Val Leu Val Leu Gln Glu Met Ile 
            340                 345                 350         


Leu Phe Phe Leu Gln Thr Pro Cys Leu Thr Asn His Ala Phe Leu Ser 
        355                 360                 365             


Ile His Thr 
    370     


<210>  5324
<211>  593
<212>  PRT
<213>  Homo Sapiens

<400>  5324

Met Cys Leu Asn Lys Thr Lys Gln Leu Phe Gly Val Ala Lys Arg Leu 
1               5                   10                  15      


Pro Phe Trp Arg Lys Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala 
            20                  25                  30          


Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly Asp Val Glu Phe 
        35                  40                  45              


Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Ile Lys 
    50                  55                  60                  


His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp Gly Leu Pro Tyr 
65                  70                  75                  80  


Leu Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr Asp Lys Glu Ile 
                85                  90                  95      


Glu Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr 
            100                 105                 110         


Thr Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe His Ser Ala Trp 
        115                 120                 125             


Leu Thr Val Leu Pro Ala Pro Gly Arg Glu Lys Glu Ile Thr Ala Ser 
    130                 135                 140                 


Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile Gly Val Phe Leu Ile 
145                 150                 155                 160 


Ala Cys Met Val Val Thr Val Ile Leu Cys Arg Met Lys Asn Thr Thr 
                165                 170                 175     


Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val His Lys Leu Thr Lys 
            180                 185                 190         


Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Glu Ser Ser Ser 
        195                 200                 205             


Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr Thr Arg Leu Ser 
    210                 215                 220                 


Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu 
225                 230                 235                 240 


Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys Leu Thr Leu Gly 
                245                 250                 255     


Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala 
            260                 265                 270         


Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val Thr Val Ala Val 
        275                 280                 285             


Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Val 
    290                 295                 300                 


Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile 
305                 310                 315                 320 


Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val 
                325                 330                 335     


Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Arg Ala Arg Arg 
            340                 345                 350         


Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg Val Pro Glu Glu 
        355                 360                 365             


Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr Gln Leu Ala Arg 
    370                 375                 380                 


Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala 
385                 390                 395                 400 


Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val Met Lys Ile Ala Asp 
                405                 410                 415     


Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr Tyr Lys Lys Thr 
            420                 425                 430         


Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe 
        435                 440                 445             


Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu 
    450                 455                 460                 


Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro 
465                 470                 475                 480 


Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys 
                485                 490                 495     


Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys Trp 
            500                 505                 510         


His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp 
        515                 520                 525             


Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu Tyr Leu Asp Leu 
    530                 535                 540                 


Ser Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro Asp Thr Arg Ser 
545                 550                 555                 560 


Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro Asp Pro Met Pro 
                565                 570                 575     


Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn Gly Ser Val Lys 
            580                 585                 590         


Thr 
    


<210>  5325
<211>  669
<212>  PRT
<213>  Homo Sapiens

<400>  5325

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Asp Ala Ile Ser Ser Gly Asp Asp Glu Asp Asp Thr 
        35                  40                  45              


Asp Gly Ala Glu Asp Phe Val Ser Glu Asn Ser Asn Asn Lys Arg Ala 
    50                  55                  60                  


Pro Tyr Trp Thr Asn Thr Glu Lys Met Glu Lys Arg Leu His Ala Val 
65                  70                  75                  80  


Pro Ala Ala Asn Thr Val Lys Phe Arg Cys Pro Ala Gly Gly Asn Pro 
                85                  90                  95      


Met Pro Thr Met Arg Trp Leu Lys Asn Gly Lys Glu Phe Lys Gln Glu 
            100                 105                 110         


His Arg Ile Gly Gly Tyr Lys Val Arg Asn Gln His Trp Ser Leu Ile 
        115                 120                 125             


Met Glu Ser Val Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys Val Val 
    130                 135                 140                 


Glu Asn Glu Tyr Gly Ser Ile Asn His Thr Tyr His Leu Asp Val Val 
145                 150                 155                 160 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
                165                 170                 175     


Ala Ser Thr Val Val Gly Gly Asp Val Glu Phe Val Cys Lys Val Tyr 
            180                 185                 190         


Ser Asp Ala Gln Pro His Ile Gln Trp Ile Lys His Val Glu Lys Asn 
        195                 200                 205             


Gly Ser Lys Tyr Gly Pro Asp Gly Leu Pro Tyr Leu Lys Val Leu Lys 
    210                 215                 220                 


Ala Ala Gly Val Asn Thr Thr Asp Lys Glu Ile Glu Val Leu Tyr Ile 
225                 230                 235                 240 


Arg Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
                245                 250                 255     


Asn Ser Ile Gly Ile Ser Phe His Ser Ala Trp Leu Thr Val Leu Pro 
            260                 265                 270         


Ala Pro Gly Arg Glu Lys Glu Ile Thr Ala Ser Pro Asp Tyr Leu Glu 
        275                 280                 285             


Ile Ala Ile Tyr Cys Ile Gly Val Phe Leu Ile Ala Cys Met Val Val 
    290                 295                 300                 


Thr Val Ile Leu Cys Arg Met Lys Asn Thr Thr Lys Lys Pro Asp Phe 
305                 310                 315                 320 


Ser Ser Gln Pro Ala Val His Lys Leu Thr Lys Arg Ile Pro Leu Arg 
                325                 330                 335     


Arg Gln Val Ser Ala Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro 
            340                 345                 350         


Leu Val Arg Ile Thr Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met 
        355                 360                 365             


Leu Ala Gly Val Ser Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu 
    370                 375                 380                 


Phe Pro Arg Asp Lys Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys 
385                 390                 395                 400 


Phe Gly Gln Val Val Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys 
                405                 410                 415     


Pro Lys Glu Ala Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala 
            420                 425                 430         


Thr Glu Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys 
        435                 440                 445             


Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr 
    450                 455                 460                 


Gln Asp Gly Pro Leu Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn 
465                 470                 475                 480 


Leu Arg Glu Tyr Leu Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser 
                485                 490                 495     


Tyr Asp Ile Asn Arg Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu 
            500                 505                 510         


Val Ser Cys Thr Tyr Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser 
        515                 520                 525             


Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr 
    530                 535                 540                 


Glu Asn Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile 
545                 550                 555                 560 


Asn Asn Ile Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val 
                565                 570                 575     


Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln 
            580                 585                 590         


Ser Asp Val Trp Ser Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu 
        595                 600                 605             


Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu 
    610                 615                 620                 


Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu 
625                 630                 635                 640 


Leu Tyr Met Met Met Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg 
                645                 650                 655     


Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Ile 
            660                 665                 


<210>  5326
<211>  707
<212>  PRT
<213>  Homo Sapiens

<400>  5326

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Asp Ala Ile Ser Ser Gly Asp Asp Glu Asp Asp Thr 
        35                  40                  45              


Asp Gly Ala Glu Asp Phe Val Ser Glu Asn Ser Asn Asn Lys Arg Ala 
    50                  55                  60                  


Pro Tyr Trp Thr Asn Thr Glu Lys Met Glu Lys Arg Leu His Ala Val 
65                  70                  75                  80  


Pro Ala Ala Asn Thr Val Lys Phe Arg Cys Pro Ala Gly Gly Asn Pro 
                85                  90                  95      


Met Pro Thr Met Arg Trp Leu Lys Asn Gly Lys Glu Phe Lys Gln Glu 
            100                 105                 110         


His Arg Ile Gly Gly Tyr Lys Val Arg Asn Gln His Trp Ser Leu Ile 
        115                 120                 125             


Met Glu Ser Val Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys Val Val 
    130                 135                 140                 


Glu Asn Glu Tyr Gly Ser Ile Asn His Thr Tyr His Leu Asp Val Val 
145                 150                 155                 160 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
                165                 170                 175     


Ala Ser Thr Val Val Gly Gly Asp Val Glu Phe Val Cys Lys Val Tyr 
            180                 185                 190         


Ser Asp Ala Gln Pro His Ile Gln Trp Ile Lys His Val Glu Lys Asn 
        195                 200                 205             


Gly Ser Lys Tyr Gly Pro Asp Gly Leu Pro Tyr Leu Lys Val Leu Lys 
    210                 215                 220                 


Ala Ala Gly Val Asn Thr Thr Asp Lys Glu Ile Glu Val Leu Tyr Ile 
225                 230                 235                 240 


Arg Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
                245                 250                 255     


Asn Ser Ile Gly Ile Ser Phe His Ser Ala Trp Leu Thr Val Leu Pro 
            260                 265                 270         


Ala Pro Gly Arg Glu Lys Glu Ile Thr Ala Ser Pro Asp Tyr Leu Glu 
        275                 280                 285             


Ile Ala Ile Tyr Cys Ile Gly Val Phe Leu Ile Ala Cys Met Val Val 
    290                 295                 300                 


Thr Val Ile Leu Cys Arg Met Lys Asn Thr Thr Lys Lys Pro Asp Phe 
305                 310                 315                 320 


Ser Ser Gln Pro Ala Val His Lys Leu Thr Lys Arg Ile Pro Leu Arg 
                325                 330                 335     


Arg Gln Val Thr Val Ser Ala Glu Ser Ser Ser Ser Met Asn Ser Asn 
            340                 345                 350         


Thr Pro Leu Val Arg Ile Thr Thr Arg Leu Ser Ser Thr Ala Asp Thr 
        355                 360                 365             


Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu Pro Glu Asp Pro Lys 
    370                 375                 380                 


Trp Glu Phe Pro Arg Asp Lys Leu Thr Leu Gly Lys Pro Leu Gly Glu 
385                 390                 395                 400 


Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Val Gly Ile Asp Lys 
                405                 410                 415     


Asp Lys Pro Lys Glu Ala Val Thr Val Ala Val Lys Met Leu Lys Asp 
            420                 425                 430         


Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met 
        435                 440                 445             


Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala 
    450                 455                 460                 


Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val Glu Tyr Ala Ser Lys 
465                 470                 475                 480 


Gly Asn Leu Arg Glu Tyr Leu Arg Ala Arg Arg Pro Pro Gly Met Glu 
                485                 490                 495     


Tyr Ser Tyr Asp Ile Asn Arg Val Pro Glu Glu Gln Met Thr Phe Lys 
            500                 505                 510         


Asp Leu Val Ser Cys Thr Tyr Gln Leu Ala Arg Gly Met Glu Tyr Leu 
        515                 520                 525             


Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu 
    530                 535                 540                 


Val Thr Glu Asn Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg 
545                 550                 555                 560 


Asp Ile Asn Asn Ile Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu 
                565                 570                 575     


Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr 
            580                 585                 590         


His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Met Trp Glu Ile Phe 
        595                 600                 605             


Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe 
    610                 615                 620                 


Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr 
625                 630                 635                 640 


Asn Glu Leu Tyr Met Met Met Arg Asp Cys Trp His Ala Val Pro Ser 
                645                 650                 655     


Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Ile Leu 
            660                 665                 670         


Thr Leu Thr Thr Asn Glu Glu Glu Lys Lys Val Ser Gly Ala Val Asp 
        675                 680                 685             


Cys His Lys Pro Pro Cys Asn Pro Ser His Leu Pro Cys Val Leu Ala 
    690                 695                 700                 


Val Asp Gln 
705         


<210>  5327
<211>  732
<212>  PRT
<213>  Homo Sapiens

<400>  5327

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Asp Ala Ile Ser Ser Gly Asp Asp Glu Asp Asp Thr 
        35                  40                  45              


Asp Gly Ala Glu Asp Phe Val Ser Glu Asn Ser Asn Asn Lys Arg Ala 
    50                  55                  60                  


Pro Tyr Trp Thr Asn Thr Glu Lys Met Glu Lys Arg Leu His Ala Val 
65                  70                  75                  80  


Pro Ala Ala Asn Thr Val Lys Phe Arg Cys Pro Ala Gly Gly Asn Pro 
                85                  90                  95      


Met Pro Thr Met Arg Trp Leu Lys Asn Gly Lys Glu Phe Lys Gln Glu 
            100                 105                 110         


His Arg Ile Gly Gly Tyr Lys Val Arg Asn Gln His Trp Ser Leu Ile 
        115                 120                 125             


Met Glu Ser Val Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys Val Val 
    130                 135                 140                 


Glu Asn Glu Tyr Gly Ser Ile Asn His Thr Tyr His Leu Asp Val Val 
145                 150                 155                 160 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
                165                 170                 175     


Ala Ser Thr Val Val Gly Gly Asp Val Glu Phe Val Cys Lys Val Tyr 
            180                 185                 190         


Ser Asp Ala Gln Pro His Ile Gln Trp Ile Lys His Val Glu Lys Asn 
        195                 200                 205             


Gly Ser Lys Tyr Gly Pro Asp Gly Leu Pro Tyr Leu Lys Val Leu Lys 
    210                 215                 220                 


Ala Ala Gly Val Asn Thr Thr Asp Lys Glu Ile Glu Val Leu Tyr Ile 
225                 230                 235                 240 


Arg Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
                245                 250                 255     


Asn Ser Ile Gly Ile Ser Phe His Ser Ala Trp Leu Thr Val Leu Pro 
            260                 265                 270         


Ala Pro Gly Arg Glu Lys Glu Ile Thr Ala Ser Pro Asp Tyr Leu Glu 
        275                 280                 285             


Ile Ala Ile Tyr Cys Ile Gly Val Phe Leu Ile Ala Cys Met Val Val 
    290                 295                 300                 


Thr Val Ile Leu Cys Arg Met Lys Asn Thr Thr Lys Lys Pro Asp Phe 
305                 310                 315                 320 


Ser Ser Gln Pro Ala Val His Lys Leu Thr Lys Arg Ile Pro Leu Arg 
                325                 330                 335     


Arg Gln Val Thr Val Ser Ala Glu Ser Ser Ser Ser Met Asn Ser Asn 
            340                 345                 350         


Thr Pro Leu Val Arg Ile Thr Thr Arg Leu Ser Ser Thr Ala Asp Thr 
        355                 360                 365             


Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu Pro Glu Asp Pro Lys 
    370                 375                 380                 


Trp Glu Phe Pro Arg Asp Lys Leu Thr Leu Gly Lys Pro Leu Gly Glu 
385                 390                 395                 400 


Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Val Gly Ile Asp Lys 
                405                 410                 415     


Asp Lys Pro Lys Glu Ala Val Thr Val Ala Val Lys Met Leu Lys Asp 
            420                 425                 430         


Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met 
        435                 440                 445             


Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala 
    450                 455                 460                 


Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val Glu Tyr Ala Ser Lys 
465                 470                 475                 480 


Gly Asn Leu Arg Glu Tyr Leu Arg Ala Arg Arg Pro Pro Gly Met Glu 
                485                 490                 495     


Tyr Ser Tyr Asp Ile Asn Arg Val Pro Glu Glu Gln Met Thr Phe Lys 
            500                 505                 510         


Asp Leu Val Ser Cys Thr Tyr Gln Leu Ala Arg Gly Met Glu Tyr Leu 
        515                 520                 525             


Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu 
    530                 535                 540                 


Val Thr Glu Asn Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg 
545                 550                 555                 560 


Asp Ile Asn Asn Ile Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu 
                565                 570                 575     


Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr 
            580                 585                 590         


His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Met Trp Glu Ile Phe 
        595                 600                 605             


Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe 
    610                 615                 620                 


Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr 
625                 630                 635                 640 


Asn Glu Leu Tyr Met Met Met Arg Asp Cys Trp His Ala Val Pro Ser 
                645                 650                 655     


Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Ile Leu 
            660                 665                 670         


Thr Leu Thr Thr Asn Glu Glu Tyr Leu Asp Leu Ser Gln Pro Leu Glu 
        675                 680                 685             


Gln Tyr Ser Pro Ser Tyr Pro Asp Thr Arg Ser Ser Cys Ser Ser Gly 
    690                 695                 700                 


Asp Asp Ser Val Phe Ser Pro Asp Pro Met Pro Tyr Glu Pro Cys Leu 
705                 710                 715                 720 


Pro Gln Tyr Pro His Ile Asn Gly Ser Val Lys Thr 
                725                 730         


<210>  5328
<211>  680
<212>  PRT
<213>  Homo Sapiens

<400>  5328

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Asp Ala Ile Ser Ser Gly Asp Asp Glu Asp Asp Thr 
        35                  40                  45              


Asp Gly Ala Glu Asp Phe Val Ser Glu Asn Ser Asn Asn Lys Arg Ala 
    50                  55                  60                  


Pro Tyr Trp Thr Asn Thr Glu Lys Met Glu Lys Arg Leu His Ala Val 
65                  70                  75                  80  


Pro Ala Ala Asn Thr Val Lys Phe Arg Cys Pro Ala Gly Gly Asn Pro 
                85                  90                  95      


Met Pro Thr Met Arg Trp Leu Lys Asn Gly Lys Glu Phe Lys Gln Glu 
            100                 105                 110         


His Arg Ile Gly Gly Tyr Lys Val Arg Asn Gln His Trp Ser Leu Ile 
        115                 120                 125             


Met Glu Ser Val Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys Val Val 
    130                 135                 140                 


Glu Asn Glu Tyr Gly Ser Ile Asn His Thr Tyr His Leu Asp Val Val 
145                 150                 155                 160 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
                165                 170                 175     


Ala Ser Thr Val Val Gly Gly Asp Val Glu Phe Val Cys Lys Val Tyr 
            180                 185                 190         


Ser Asp Ala Gln Pro His Ile Gln Trp Ile Lys His Val Glu Lys Asn 
        195                 200                 205             


Gly Ser Lys Tyr Gly Pro Asp Gly Leu Pro Tyr Leu Lys Val Leu Lys 
    210                 215                 220                 


His Ser Gly Ile Asn Ser Ser Asn Ala Glu Val Leu Ala Leu Phe Asn 
225                 230                 235                 240 


Val Thr Glu Ala Asp Ala Gly Glu Tyr Ile Cys Lys Val Ser Asn Tyr 
                245                 250                 255     


Ile Gly Gln Ala Asn Gln Ser Ala Trp Leu Thr Val Leu Pro Lys Gln 
            260                 265                 270         


Gln Ala Pro Gly Arg Glu Lys Glu Ile Thr Ala Ser Pro Asp Tyr Leu 
        275                 280                 285             


Glu Ile Ala Ile Tyr Cys Ile Gly Val Phe Leu Ile Ala Cys Met Val 
    290                 295                 300                 


Val Thr Val Ile Leu Cys Arg Met Lys Asn Thr Thr Lys Lys Pro Asp 
305                 310                 315                 320 


Phe Ser Ser Gln Pro Ala Val His Lys Leu Thr Lys Arg Ile Pro Leu 
                325                 330                 335     


Arg Arg Gln Val Thr Val Ser Ala Glu Ser Ser Ser Ser Met Asn Ser 
            340                 345                 350         


Asn Thr Pro Leu Val Arg Ile Thr Thr Arg Leu Ser Ser Thr Ala Asp 
        355                 360                 365             


Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu Pro Glu Asp Pro 
    370                 375                 380                 


Lys Trp Glu Phe Pro Arg Asp Lys Leu Thr Leu Gly Lys Pro Leu Gly 
385                 390                 395                 400 


Glu Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Val Gly Ile Asp 
                405                 410                 415     


Lys Asp Lys Pro Lys Glu Ala Val Thr Val Ala Val Lys Met Leu Lys 
            420                 425                 430         


Asp Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu 
        435                 440                 445             


Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly 
    450                 455                 460                 


Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val Glu Tyr Ala Ser 
465                 470                 475                 480 


Lys Gly Asn Leu Arg Glu Tyr Leu Arg Ala Arg Arg Pro Pro Gly Met 
                485                 490                 495     


Glu Tyr Ser Tyr Asp Ile Asn Arg Val Pro Glu Glu Gln Met Thr Phe 
            500                 505                 510         


Lys Asp Leu Val Ser Cys Thr Tyr Gln Leu Ala Arg Gly Met Glu Tyr 
        515                 520                 525             


Leu Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val 
    530                 535                 540                 


Leu Val Thr Glu Asn Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala 
545                 550                 555                 560 


Arg Asp Ile Asn Asn Ile Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg 
                565                 570                 575     


Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr 
            580                 585                 590         


Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Met Trp Glu Ile 
        595                 600                 605             


Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu 
    610                 615                 620                 


Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys 
625                 630                 635                 640 


Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys Trp His Ala Val Pro 
                645                 650                 655     


Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Ile 
            660                 665                 670         


Leu Thr Leu Thr Thr Asn Glu Ile 
        675                 680 


<210>  5329
<211>  64
<212>  PRT
<213>  Homo Sapiens

<400>  5329

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Asp Ala Ile Ser Ser Gly Asp Asp Glu Asp Asp Thr 
        35                  40                  45              


Asp Gly Ala Glu Asp Phe Val Ser Glu Asn Ser Asn Asn Lys Ser Lys 
    50                  55                  60                  


<210>  5330
<211>  144
<212>  PRT
<213>  Homo Sapiens

<400>  5330

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu 
        35                  40                  45              


Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Met Pro Ser His Pro 
    50                  55                  60                  


Glu Met Met Arg Met Thr Pro Met Val Arg Lys Ile Leu Ser Val Arg 
65                  70                  75                  80  


Thr Val Thr Thr Arg Val Ser Asn Cys Pro Ala Pro Met Val Pro Glu 
                85                  90                  95      


Arg Gly Ala Trp Arg Glu Val Leu Pro Val Thr Cys Leu Leu Val Asp 
            100                 105                 110         


Ser Ser Ala Pro Cys Cys Val Pro Arg Pro Leu Pro Phe Pro Ala Val 
        115                 120                 125             


Ser Thr Phe Leu Thr Phe Lys Pro Glu Asn Lys Pro Val Leu Leu His 
    130                 135                 140                 


<210>  5331
<211>  709
<212>  PRT
<213>  Homo Sapiens

<400>  5331

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu 
        35                  40                  45              


Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu 
    50                  55                  60                  


Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly 
65                  70                  75                  80  


Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly 
                85                  90                  95      


Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr 
            100                 105                 110         


Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile 
        115                 120                 125             


Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val 
    130                 135                 140                 


Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu 
145                 150                 155                 160 


Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys 
                165                 170                 175     


Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu 
            180                 185                 190         


Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys 
        195                 200                 205             


Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser 
    210                 215                 220                 


Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile 
225                 230                 235                 240 


Asn His Thr Tyr His Leu Asp Val Val Ala Pro Gly Arg Glu Lys Glu 
                245                 250                 255     


Ile Thr Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile Gly 
            260                 265                 270         


Val Phe Leu Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg Met 
        275                 280                 285             


Lys Asn Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val His 
    290                 295                 300                 


Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala 
305                 310                 315                 320 


Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr 
                325                 330                 335     


Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser 
            340                 345                 350         


Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys 
        355                 360                 365             


Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val 
    370                 375                 380                 


Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val 
385                 390                 395                 400 


Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu 
                405                 410                 415     


Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His 
            420                 425                 430         


Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu 
        435                 440                 445             


Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu 
    450                 455                 460                 


Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg 
465                 470                 475                 480 


Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr 
                485                 490                 495     


Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His 
            500                 505                 510         


Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val Met 
        515                 520                 525             


Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr 
    530                 535                 540                 


Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro 
545                 550                 555                 560 


Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser 
                565                 570                 575     


Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr 
            580                 585                 590         


Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His 
        595                 600                 605             


Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met Met 
    610                 615                 620                 


Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln 
625                 630                 635                 640 


Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu 
                645                 650                 655     


Tyr Leu Asp Leu Ser Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro 
            660                 665                 670         


Asp Thr Arg Ser Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro 
        675                 680                 685             


Asp Pro Met Pro Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn 
    690                 695                 700                 


Gly Ser Val Lys Thr 
705                 


<210>  5332
<211>  821
<212>  PRT
<213>  Homo Sapiens

<400>  5332

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu 
        35                  40                  45              


Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu 
    50                  55                  60                  


Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly 
65                  70                  75                  80  


Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly 
                85                  90                  95      


Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr 
            100                 105                 110         


Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile 
        115                 120                 125             


Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val 
    130                 135                 140                 


Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu 
145                 150                 155                 160 


Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys 
                165                 170                 175     


Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu 
            180                 185                 190         


Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys 
        195                 200                 205             


Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser 
    210                 215                 220                 


Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile 
225                 230                 235                 240 


Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro 
                245                 250                 255     


Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly 
            260                 265                 270         


Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile 
        275                 280                 285             


Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp 
    290                 295                 300                 


Gly Leu Pro Tyr Leu Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr 
305                 310                 315                 320 


Asp Lys Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp 
                325                 330                 335     


Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe 
            340                 345                 350         


His Ser Ala Trp Leu Thr Val Leu Pro Ala Pro Gly Arg Glu Lys Glu 
        355                 360                 365             


Ile Thr Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile Gly 
    370                 375                 380                 


Val Phe Leu Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg Met 
385                 390                 395                 400 


Lys Asn Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val His 
                405                 410                 415     


Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala 
            420                 425                 430         


Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr 
        435                 440                 445             


Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser 
    450                 455                 460                 


Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys 
465                 470                 475                 480 


Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val 
                485                 490                 495     


Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val 
            500                 505                 510         


Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu 
        515                 520                 525             


Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His 
    530                 535                 540                 


Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu 
545                 550                 555                 560 


Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu 
                565                 570                 575     


Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg 
            580                 585                 590         


Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr 
        595                 600                 605             


Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His 
    610                 615                 620                 


Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val Met 
625                 630                 635                 640 


Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr 
                645                 650                 655     


Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro 
            660                 665                 670         


Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser 
        675                 680                 685             


Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr 
    690                 695                 700                 


Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His 
705                 710                 715                 720 


Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met Met 
                725                 730                 735     


Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln 
            740                 745                 750         


Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu 
        755                 760                 765             


Tyr Leu Asp Leu Ser Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro 
    770                 775                 780                 


Asp Thr Arg Ser Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro 
785                 790                 795                 800 


Asp Pro Met Pro Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn 
                805                 810                 815     


Gly Ser Val Lys Thr 
            820     


<210>  5333
<211>  821
<212>  PRT
<213>  Homo Sapiens

<400>  5333

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu 
        35                  40                  45              


Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu 
    50                  55                  60                  


Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly 
65                  70                  75                  80  


Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly 
                85                  90                  95      


Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr 
            100                 105                 110         


Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile 
        115                 120                 125             


Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val 
    130                 135                 140                 


Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu 
145                 150                 155                 160 


Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys 
                165                 170                 175     


Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu 
            180                 185                 190         


Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys 
        195                 200                 205             


Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser 
    210                 215                 220                 


Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile 
225                 230                 235                 240 


Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro 
                245                 250                 255     


Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly 
            260                 265                 270         


Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile 
        275                 280                 285             


Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp 
    290                 295                 300                 


Gly Leu Pro Tyr Leu Lys Val Leu Lys Val Phe Ala Ala Gly Val Asn 
305                 310                 315                 320 


Thr Thr Asp Lys Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr Phe 
                325                 330                 335     


Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Ile 
            340                 345                 350         


Ser Phe His Ser Ala Trp Leu Thr Val Leu Pro Ala Pro Gly Arg Glu 
        355                 360                 365             


Lys Glu Ile Thr Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys 
    370                 375                 380                 


Ile Gly Val Phe Leu Ile Ala Cys Met Val Val Thr Val Ile Leu Cys 
385                 390                 395                 400 


Arg Met Lys Asn Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala 
                405                 410                 415     


Val His Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Ser Ala 
            420                 425                 430         


Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr 
        435                 440                 445             


Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser 
    450                 455                 460                 


Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys 
465                 470                 475                 480 


Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val 
                485                 490                 495     


Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val 
            500                 505                 510         


Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu 
        515                 520                 525             


Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His 
    530                 535                 540                 


Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu 
545                 550                 555                 560 


Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu 
                565                 570                 575     


Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg 
            580                 585                 590         


Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr 
        595                 600                 605             


Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His 
    610                 615                 620                 


Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val Met 
625                 630                 635                 640 


Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr 
                645                 650                 655     


Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro 
            660                 665                 670         


Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser 
        675                 680                 685             


Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr 
    690                 695                 700                 


Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His 
705                 710                 715                 720 


Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met Met 
                725                 730                 735     


Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln 
            740                 745                 750         


Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu 
        755                 760                 765             


Tyr Leu Asp Leu Ser Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro 
    770                 775                 780                 


Asp Thr Arg Ser Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro 
785                 790                 795                 800 


Asp Pro Met Pro Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn 
                805                 810                 815     


Gly Ser Val Lys Thr 
            820     


<210>  5334
<211>  819
<212>  PRT
<213>  Homo Sapiens

<400>  5334

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu 
        35                  40                  45              


Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu 
    50                  55                  60                  


Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly 
65                  70                  75                  80  


Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly 
                85                  90                  95      


Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr 
            100                 105                 110         


Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile 
        115                 120                 125             


Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val 
    130                 135                 140                 


Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu 
145                 150                 155                 160 


Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys 
                165                 170                 175     


Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu 
            180                 185                 190         


Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys 
        195                 200                 205             


Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser 
    210                 215                 220                 


Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile 
225                 230                 235                 240 


Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro 
                245                 250                 255     


Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly 
            260                 265                 270         


Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile 
        275                 280                 285             


Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp 
    290                 295                 300                 


Gly Leu Pro Tyr Leu Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr 
305                 310                 315                 320 


Asp Lys Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp 
                325                 330                 335     


Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe 
            340                 345                 350         


His Ser Ala Trp Leu Thr Val Leu Pro Ala Pro Gly Arg Glu Lys Glu 
        355                 360                 365             


Ile Thr Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile Gly 
    370                 375                 380                 


Val Phe Leu Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg Met 
385                 390                 395                 400 


Lys Asn Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val His 
                405                 410                 415     


Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Ser Ala Glu Ser 
            420                 425                 430         


Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr Thr Arg 
        435                 440                 445             


Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser Glu Tyr 
    450                 455                 460                 


Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys Leu Thr 
465                 470                 475                 480 


Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Met Ala 
                485                 490                 495     


Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val Thr Val 
            500                 505                 510         


Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu Ser Asp 
        515                 520                 525             


Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn 
    530                 535                 540                 


Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val 
545                 550                 555                 560 


Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Arg Ala 
                565                 570                 575     


Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg Val Pro 
            580                 585                 590         


Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr Gln Leu 
        595                 600                 605             


Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His Arg Asp 
    610                 615                 620                 


Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val Met Lys Ile 
625                 630                 635                 640 


Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr Tyr Lys 
                645                 650                 655     


Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala 
            660                 665                 670         


Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly 
        675                 680                 685             


Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly 
    690                 695                 700                 


Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met 
705                 710                 715                 720 


Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp 
                725                 730                 735     


Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val 
            740                 745                 750         


Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu Tyr Leu 
        755                 760                 765             


Asp Leu Ser Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro Asp Thr 
    770                 775                 780                 


Arg Ser Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro Asp Pro 
785                 790                 795                 800 


Met Pro Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn Gly Ser 
                805                 810                 815     


Val Lys Thr 
            


<210>  5335
<211>  768
<212>  PRT
<213>  Homo Sapiens

<400>  5335

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu 
        35                  40                  45              


Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu 
    50                  55                  60                  


Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly 
65                  70                  75                  80  


Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly 
                85                  90                  95      


Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr 
            100                 105                 110         


Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile 
        115                 120                 125             


Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val 
    130                 135                 140                 


Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu 
145                 150                 155                 160 


Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys 
                165                 170                 175     


Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu 
            180                 185                 190         


Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys 
        195                 200                 205             


Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser 
    210                 215                 220                 


Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile 
225                 230                 235                 240 


Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro 
                245                 250                 255     


Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly 
            260                 265                 270         


Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile 
        275                 280                 285             


Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp 
    290                 295                 300                 


Gly Leu Pro Tyr Leu Lys Val Leu Lys His Ser Gly Ile Asn Ser Ser 
305                 310                 315                 320 


Asn Ala Glu Val Leu Ala Leu Phe Asn Val Thr Glu Ala Asp Ala Gly 
                325                 330                 335     


Glu Tyr Ile Cys Lys Val Ser Asn Tyr Ile Gly Gln Ala Asn Gln Ser 
            340                 345                 350         


Ala Trp Leu Thr Val Leu Pro Lys Gln Gln Ala Pro Gly Arg Glu Lys 
        355                 360                 365             


Glu Ile Thr Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile 
    370                 375                 380                 


Gly Val Phe Leu Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg 
385                 390                 395                 400 


Met Lys Asn Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val 
                405                 410                 415     


His Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser 
            420                 425                 430         


Ala Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile 
        435                 440                 445             


Thr Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val 
    450                 455                 460                 


Ser Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp 
465                 470                 475                 480 


Lys Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val 
                485                 490                 495     


Val Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala 
            500                 505                 510         


Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp 
        515                 520                 525             


Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys 
    530                 535                 540                 


His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro 
545                 550                 555                 560 


Leu Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr 
                565                 570                 575     


Leu Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn 
            580                 585                 590         


Arg Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr 
        595                 600                 605             


Tyr Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile 
    610                 615                 620                 


His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val 
625                 630                 635                 640 


Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp 
                645                 650                 655     


Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala 
            660                 665                 670         


Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp 
        675                 680                 685             


Ser Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro 
    690                 695                 700                 


Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly 
705                 710                 715                 720 


His Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met 
                725                 730                 735     


Met Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys 
            740                 745                 750         


Gln Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu 
        755                 760                 765             


<210>  5336
<211>  769
<212>  PRT
<213>  Homo Sapiens

<400>  5336

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu 
        35                  40                  45              


Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu 
    50                  55                  60                  


Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly 
65                  70                  75                  80  


Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly 
                85                  90                  95      


Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr 
            100                 105                 110         


Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile 
        115                 120                 125             


Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val 
    130                 135                 140                 


Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu 
145                 150                 155                 160 


Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys 
                165                 170                 175     


Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu 
            180                 185                 190         


Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys 
        195                 200                 205             


Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser 
    210                 215                 220                 


Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile 
225                 230                 235                 240 


Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro 
                245                 250                 255     


Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly 
            260                 265                 270         


Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile 
        275                 280                 285             


Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp 
    290                 295                 300                 


Gly Leu Pro Tyr Leu Lys Val Leu Lys His Ser Gly Ile Asn Ser Ser 
305                 310                 315                 320 


Asn Ala Glu Val Leu Ala Leu Phe Asn Val Thr Glu Ala Asp Ala Gly 
                325                 330                 335     


Glu Tyr Ile Cys Lys Val Ser Asn Tyr Ile Gly Gln Ala Asn Gln Ser 
            340                 345                 350         


Ala Trp Leu Thr Val Leu Pro Lys Gln Gln Ala Pro Gly Arg Glu Lys 
        355                 360                 365             


Glu Ile Thr Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile 
    370                 375                 380                 


Gly Val Phe Leu Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg 
385                 390                 395                 400 


Met Lys Asn Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val 
                405                 410                 415     


His Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser 
            420                 425                 430         


Ala Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile 
        435                 440                 445             


Thr Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val 
    450                 455                 460                 


Ser Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp 
465                 470                 475                 480 


Lys Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val 
                485                 490                 495     


Val Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala 
            500                 505                 510         


Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp 
        515                 520                 525             


Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys 
    530                 535                 540                 


His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro 
545                 550                 555                 560 


Leu Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr 
                565                 570                 575     


Leu Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn 
            580                 585                 590         


Arg Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr 
        595                 600                 605             


Tyr Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile 
    610                 615                 620                 


His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val 
625                 630                 635                 640 


Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp 
                645                 650                 655     


Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala 
            660                 665                 670         


Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp 
        675                 680                 685             


Ser Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro 
    690                 695                 700                 


Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly 
705                 710                 715                 720 


His Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met 
                725                 730                 735     


Met Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys 
            740                 745                 750         


Gln Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu 
        755                 760                 765             


Ile 
    


<210>  5337
<211>  705
<212>  PRT
<213>  Homo Sapiens

<400>  5337

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu 
        35                  40                  45              


Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu 
    50                  55                  60                  


Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly 
65                  70                  75                  80  


Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly 
                85                  90                  95      


Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr 
            100                 105                 110         


Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile 
        115                 120                 125             


Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val 
    130                 135                 140                 


Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu 
145                 150                 155                 160 


Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys 
                165                 170                 175     


Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu 
            180                 185                 190         


Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys 
        195                 200                 205             


Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser 
    210                 215                 220                 


Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile 
225                 230                 235                 240 


Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro 
                245                 250                 255     


Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly 
            260                 265                 270         


Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile 
        275                 280                 285             


Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp 
    290                 295                 300                 


Gly Leu Pro Tyr Leu Lys Val Leu Lys Val Ser Ala Glu Ser Ser Ser 
305                 310                 315                 320 


Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr Thr Arg Leu Ser 
                325                 330                 335     


Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu 
            340                 345                 350         


Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys Leu Thr Leu Gly 
        355                 360                 365             


Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala 
    370                 375                 380                 


Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val Thr Val Ala Val 
385                 390                 395                 400 


Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Val 
                405                 410                 415     


Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile 
            420                 425                 430         


Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val 
        435                 440                 445             


Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Arg Ala Arg Arg 
    450                 455                 460                 


Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg Val Pro Glu Glu 
465                 470                 475                 480 


Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr Gln Leu Ala Arg 
                485                 490                 495     


Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala 
            500                 505                 510         


Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val Met Lys Ile Ala Asp 
        515                 520                 525             


Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr Tyr Lys Lys Thr 
    530                 535                 540                 


Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe 
545                 550                 555                 560 


Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu 
                565                 570                 575     


Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro 
            580                 585                 590         


Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys 
        595                 600                 605             


Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys Trp 
    610                 615                 620                 


His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp 
625                 630                 635                 640 


Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu Tyr Leu Asp Leu 
                645                 650                 655     


Ser Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro Asp Thr Arg Ser 
            660                 665                 670         


Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro Asp Pro Met Pro 
        675                 680                 685             


Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn Gly Ser Val Lys 
    690                 695                 700                 


Thr 
705 


<210>  5338
<211>  822
<212>  PRT
<213>  Homo Sapiens

<400>  5338

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu 
        35                  40                  45              


Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu 
    50                  55                  60                  


Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly 
65                  70                  75                  80  


Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly 
                85                  90                  95      


Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr 
            100                 105                 110         


Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile 
        115                 120                 125             


Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val 
    130                 135                 140                 


Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu 
145                 150                 155                 160 


Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys 
                165                 170                 175     


Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu 
            180                 185                 190         


Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys 
        195                 200                 205             


Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser 
    210                 215                 220                 


Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile 
225                 230                 235                 240 


Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro 
                245                 250                 255     


Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly 
            260                 265                 270         


Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile 
        275                 280                 285             


Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp 
    290                 295                 300                 


Gly Leu Pro Tyr Leu Lys Val Leu Lys His Ser Gly Ile Asn Ser Ser 
305                 310                 315                 320 


Asn Ala Glu Val Leu Ala Leu Phe Asn Val Thr Glu Ala Asp Ala Gly 
                325                 330                 335     


Glu Tyr Ile Cys Lys Val Ser Asn Tyr Ile Gly Gln Ala Asn Gln Ser 
            340                 345                 350         


Ala Trp Leu Thr Val Leu Pro Lys Gln Gln Ala Pro Gly Arg Glu Lys 
        355                 360                 365             


Glu Ile Thr Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile 
    370                 375                 380                 


Gly Val Phe Leu Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg 
385                 390                 395                 400 


Met Lys Asn Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val 
                405                 410                 415     


His Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser 
            420                 425                 430         


Ala Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile 
        435                 440                 445             


Thr Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val 
    450                 455                 460                 


Ser Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp 
465                 470                 475                 480 


Lys Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val 
                485                 490                 495     


Val Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala 
            500                 505                 510         


Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp 
        515                 520                 525             


Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys 
    530                 535                 540                 


His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro 
545                 550                 555                 560 


Leu Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr 
                565                 570                 575     


Leu Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn 
            580                 585                 590         


Arg Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr 
        595                 600                 605             


Tyr Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile 
    610                 615                 620                 


His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val 
625                 630                 635                 640 


Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp 
                645                 650                 655     


Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala 
            660                 665                 670         


Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp 
        675                 680                 685             


Ser Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro 
    690                 695                 700                 


Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly 
705                 710                 715                 720 


His Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met 
                725                 730                 735     


Met Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys 
            740                 745                 750         


Gln Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu 
        755                 760                 765             


Glu Tyr Leu Asp Leu Ser Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr 
    770                 775                 780                 


Pro Asp Thr Arg Ser Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser 
785                 790                 795                 800 


Pro Asp Pro Met Pro Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile 
                805                 810                 815     


Asn Gly Ser Val Lys Thr 
            820         


<210>  5339
<211>  254
<212>  PRT
<213>  Homo Sapiens

<400>  5339

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu 
        35                  40                  45              


Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu 
    50                  55                  60                  


Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly 
65                  70                  75                  80  


Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly 
                85                  90                  95      


Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr 
            100                 105                 110         


Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile 
        115                 120                 125             


Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val 
    130                 135                 140                 


Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu 
145                 150                 155                 160 


Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys 
                165                 170                 175     


Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu 
            180                 185                 190         


Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys 
        195                 200                 205             


Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser 
    210                 215                 220                 


Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile 
225                 230                 235                 240 


Asn His Thr Tyr His Leu Asp Val Val Gly Ser Gln Gly Leu 
                245                 250                 


<210>  5340
<211>  704
<212>  PRT
<213>  Homo Sapiens

<400>  5340

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Gly Ala Pro Tyr Trp Thr Asn Thr Glu Lys Met Glu 
        35                  40                  45              


Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys Phe Arg Cys 
    50                  55                  60                  


Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu Lys Asn Gly 
65                  70                  75                  80  


Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys Val Arg Asn 
                85                  90                  95      


Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser Asp Lys Gly 
            100                 105                 110         


Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile Asn His Thr 
        115                 120                 125             


Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile Leu Gln 
    130                 135                 140                 


Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly Asp Val Glu 
145                 150                 155                 160 


Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Ile 
                165                 170                 175     


Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp Gly Leu Pro 
            180                 185                 190         


Tyr Leu Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr Asp Lys Glu 
        195                 200                 205             


Ile Glu Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp Ala Gly Glu 
    210                 215                 220                 


Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe His Ser Ala 
225                 230                 235                 240 


Trp Leu Thr Val Leu Pro Ala Pro Gly Arg Glu Lys Glu Ile Thr Ala 
                245                 250                 255     


Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile Gly Val Phe Leu 
            260                 265                 270         


Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg Met Lys Asn Thr 
        275                 280                 285             


Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val His Lys Leu Thr 
    290                 295                 300                 


Lys Arg Ile Pro Leu Arg Arg Gln Val Ser Ala Glu Ser Ser Ser Ser 
305                 310                 315                 320 


Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr Thr Arg Leu Ser Ser 
                325                 330                 335     


Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu Pro 
            340                 345                 350         


Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys Leu Thr Leu Gly Lys 
        355                 360                 365             


Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Val 
    370                 375                 380                 


Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val Thr Val Ala Val Lys 
385                 390                 395                 400 


Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Val Ser 
                405                 410                 415     


Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn 
            420                 425                 430         


Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val Glu 
        435                 440                 445             


Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Arg Ala Arg Arg Pro 
    450                 455                 460                 


Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg Val Pro Glu Glu Gln 
465                 470                 475                 480 


Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr Gln Leu Ala Arg Gly 
                485                 490                 495     


Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala 
            500                 505                 510         


Arg Asn Val Leu Val Thr Glu Asn Asn Val Met Lys Ile Ala Asp Phe 
        515                 520                 525             


Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr Tyr Lys Lys Thr Thr 
    530                 535                 540                 


Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp 
545                 550                 555                 560 


Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Met 
                565                 570                 575     


Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val 
            580                 585                 590         


Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro 
        595                 600                 605             


Ala Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys Trp His 
    610                 615                 620                 


Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu 
625                 630                 635                 640 


Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu Tyr Leu Asp Leu Ser 
                645                 650                 655     


Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro Asp Thr Arg Ser Ser 
            660                 665                 670         


Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro Asp Pro Met Pro Tyr 
        675                 680                 685             


Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn Gly Ser Val Lys Thr 
    690                 695                 700                 


<210>  5341
<211>  707
<212>  PRT
<213>  Homo Sapiens

<400>  5341

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Gly Ala Pro Tyr Trp Thr Asn Thr Glu Lys Met Glu 
        35                  40                  45              


Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys Phe Arg Cys 
    50                  55                  60                  


Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu Lys Asn Gly 
65                  70                  75                  80  


Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys Val Arg Asn 
                85                  90                  95      


Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser Asp Lys Gly 
            100                 105                 110         


Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile Asn His Thr 
        115                 120                 125             


Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile Leu Gln 
    130                 135                 140                 


Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly Asp Val Glu 
145                 150                 155                 160 


Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Ile 
                165                 170                 175     


Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp Gly Leu Pro 
            180                 185                 190         


Tyr Leu Lys Val Leu Lys His Ser Gly Ile Asn Ser Ser Asn Ala Glu 
        195                 200                 205             


Val Leu Ala Leu Phe Asn Val Thr Glu Ala Asp Ala Gly Glu Tyr Ile 
    210                 215                 220                 


Cys Lys Val Ser Asn Tyr Ile Gly Gln Ala Asn Gln Ser Ala Trp Leu 
225                 230                 235                 240 


Thr Val Leu Pro Lys Gln Gln Ala Pro Gly Arg Glu Lys Glu Ile Thr 
                245                 250                 255     


Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile Gly Val Phe 
            260                 265                 270         


Leu Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg Met Lys Asn 
        275                 280                 285             


Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val His Lys Leu 
    290                 295                 300                 


Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Glu Ser 
305                 310                 315                 320 


Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr Thr Arg 
                325                 330                 335     


Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser Glu Tyr 
            340                 345                 350         


Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys Leu Thr 
        355                 360                 365             


Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Met Ala 
    370                 375                 380                 


Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val Thr Val 
385                 390                 395                 400 


Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu Ser Asp 
                405                 410                 415     


Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn 
            420                 425                 430         


Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val 
        435                 440                 445             


Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Arg Ala 
    450                 455                 460                 


Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg Val Pro 
465                 470                 475                 480 


Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr Gln Leu 
                485                 490                 495     


Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His Arg Asp 
            500                 505                 510         


Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val Met Lys Ile 
        515                 520                 525             


Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr Tyr Lys 
    530                 535                 540                 


Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala 
545                 550                 555                 560 


Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly 
                565                 570                 575     


Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly 
            580                 585                 590         


Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met 
        595                 600                 605             


Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp 
    610                 615                 620                 


Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val 
625                 630                 635                 640 


Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu Tyr Leu 
                645                 650                 655     


Asp Leu Ser Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro Asp Thr 
            660                 665                 670         


Arg Ser Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro Asp Pro 
        675                 680                 685             


Met Pro Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn Gly Ser 
    690                 695                 700                 


Val Lys Thr 
705         


<210>  5342
<211>  251
<212>  PRT
<213>  Homo Sapiens

<400>  5342

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Gly Ala Pro Tyr Trp Thr Asn Thr Glu Lys Met Glu 
        35                  40                  45              


Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys Phe Arg Cys 
    50                  55                  60                  


Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu Lys Asn Gly 
65                  70                  75                  80  


Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys Val Arg Asn 
                85                  90                  95      


Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser Asp Lys Gly 
            100                 105                 110         


Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile Asn His Thr 
        115                 120                 125             


Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile Leu Gln 
    130                 135                 140                 


Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly Asp Val Glu 
145                 150                 155                 160 


Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Ile 
                165                 170                 175     


Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp Gly Leu Pro 
            180                 185                 190         


Tyr Leu Lys Val Leu Lys His Ser Gly Ile Asn Ser Ser Asn Ala Glu 
        195                 200                 205             


Val Leu Ala Leu Phe Asn Val Thr Glu Ala Asp Ala Gly Glu Tyr Ile 
    210                 215                 220                 


Cys Lys Val Ser Asn Tyr Ile Gly Gln Ala Asn Gln Ser Ala Trp Leu 
225                 230                 235                 240 


Thr Val Leu Pro Lys Gln Gln Gly Arg Arg Cys 
                245                 250     


<210>  5343
<211>  86
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5343

Xaa Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys 
1               5                   10                  15      


Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr 
            20                  25                  30          


Met Met Met Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr 
        35                  40                  45              


Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr 
    50                  55                  60                  


Asn Glu Glu Tyr Leu Asp Leu Ser Gln Pro Leu Glu Pro Tyr Ser Pro 
65                  70                  75                  80  


Cys Tyr Pro Asp Pro Arg 
                85      


<210>  5344
<211>  136
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5344

Xaa Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr Leu 
1               5                   10                  15      


Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu Val 
            20                  25                  30          


Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu Lys 
        35                  40                  45              


Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly Pro 
    50                  55                  60                  


Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly Ala 
65                  70                  75                  80  


Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr Val 
                85                  90                  95      


Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile Ser 
            100                 105                 110         


Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val Ser 
        115                 120                 125             


Glu Asn Ser Asn Asn Lys Ser Lys 
    130                 135     


<210>  5345
<211>  364
<212>  PRT
<213>  Homo Sapiens

<400>  5345

Met Gly Ala Pro Ala Cys Ala Leu Ala Leu Cys Val Ala Val Ala Ile 
1               5                   10                  15      


Val Ala Gly Ala Ser Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val 
            20                  25                  30          


Gly Arg Ala Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln 
        35                  40                  45              


Leu Val Phe Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro 
    50                  55                  60                  


Gly Gly Gly Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly 
65                  70                  75                  80  


Leu Val Pro Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val 
                85                  90                  95      


Leu Asn Ala Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg 
            100                 105                 110         


Leu Thr Gln Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala 
        115                 120                 125             


Pro Ser Ser Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr 
    130                 135                 140                 


Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp 
145                 150                 155                 160 


Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys 
                165                 170                 175     


Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly 
            180                 185                 190         


Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His 
        195                 200                 205             


Gln Gln Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly 
    210                 215                 220                 


Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr 
225                 230                 235                 240 


Tyr Thr Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln 
                245                 250                 255     


Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu 
            260                 265                 270         


Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu 
        275                 280                 285             


Lys His Val Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro 
    290                 295                 300                 


Tyr Val Thr Val Leu Lys Ser Trp Ile Ser Glu Ser Val Glu Ala Asp 
305                 310                 315                 320 


Val Arg Leu Arg Leu Ala Asn Val Ser Glu Arg Asp Gly Gly Glu Tyr 
                325                 330                 335     


Leu Cys Arg Ala Thr Asn Phe Ile Gly Val Ala Glu Lys Ala Phe Trp 
            340                 345                 350         


Leu Ser Val His Gly Pro Arg Ala Asp Gly Gly Arg 
        355                 360                 


<210>  5346
<211>  694
<212>  PRT
<213>  Homo Sapiens

<400>  5346

Met Gly Ala Pro Ala Cys Ala Leu Ala Leu Cys Val Ala Val Ala Ile 
1               5                   10                  15      


Val Ala Gly Ala Ser Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val 
            20                  25                  30          


Gly Arg Ala Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln 
        35                  40                  45              


Leu Val Phe Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro 
    50                  55                  60                  


Gly Gly Gly Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly 
65                  70                  75                  80  


Leu Val Pro Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val 
                85                  90                  95      


Leu Asn Ala Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg 
            100                 105                 110         


Leu Thr Gln Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala 
        115                 120                 125             


Pro Ser Ser Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr 
    130                 135                 140                 


Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp 
145                 150                 155                 160 


Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys 
                165                 170                 175     


Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly 
            180                 185                 190         


Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His 
        195                 200                 205             


Gln Gln Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly 
    210                 215                 220                 


Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr 
225                 230                 235                 240 


Tyr Thr Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln 
                245                 250                 255     


Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu 
            260                 265                 270         


Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu 
        275                 280                 285             


Lys His Val Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro 
    290                 295                 300                 


Tyr Val Thr Val Leu Lys Val Ser Leu Glu Ser Asn Ala Ser Met Ser 
305                 310                 315                 320 


Ser Asn Thr Pro Leu Val Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly 
                325                 330                 335     


Pro Thr Leu Ala Asn Val Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys 
            340                 345                 350         


Trp Glu Leu Ser Arg Ala Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu 
        355                 360                 365             


Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Ile Gly Ile Asp Lys 
    370                 375                 380                 


Asp Arg Ala Ala Lys Pro Val Thr Val Ala Val Lys Met Leu Lys Asp 
385                 390                 395                 400 


Asp Ala Thr Asp Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met 
                405                 410                 415     


Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala 
            420                 425                 430         


Cys Thr Gln Gly Gly Pro Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys 
        435                 440                 445             


Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg Pro Pro Gly Leu Asp 
    450                 455                 460                 


Tyr Ser Phe Asp Thr Cys Lys Pro Pro Glu Glu Gln Leu Thr Phe Lys 
465                 470                 475                 480 


Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu 
                485                 490                 495     


Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu 
            500                 505                 510         


Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg 
        515                 520                 525             


Asp Val His Asn Leu Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu 
    530                 535                 540                 


Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr 
545                 550                 555                 560 


His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe 
                565                 570                 575     


Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe 
            580                 585                 590         


Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr 
        595                 600                 605             


His Asp Leu Tyr Met Ile Met Arg Glu Cys Trp His Ala Ala Pro Ser 
    610                 615                 620                 


Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Val Leu 
625                 630                 635                 640 


Thr Val Thr Ser Thr Asp Glu Tyr Leu Asp Leu Ser Ala Pro Phe Glu 
                645                 650                 655     


Gln Tyr Ser Pro Gly Gly Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly 
            660                 665                 670         


Asp Asp Ser Val Phe Ala His Asp Leu Leu Pro Pro Ala Pro Pro Ser 
        675                 680                 685             


Ser Gly Gly Ser Arg Thr 
    690                 


<210>  5347
<211>  808
<212>  PRT
<213>  Homo Sapiens

<400>  5347

Met Gly Ala Pro Ala Cys Ala Leu Ala Leu Cys Val Ala Val Ala Ile 
1               5                   10                  15      


Val Ala Gly Ala Ser Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val 
            20                  25                  30          


Gly Arg Ala Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln 
        35                  40                  45              


Leu Val Phe Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro 
    50                  55                  60                  


Gly Gly Gly Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly 
65                  70                  75                  80  


Leu Val Pro Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val 
                85                  90                  95      


Leu Asn Ala Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg 
            100                 105                 110         


Leu Thr Gln Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala 
        115                 120                 125             


Pro Ser Ser Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr 
    130                 135                 140                 


Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp 
145                 150                 155                 160 


Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys 
                165                 170                 175     


Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly 
            180                 185                 190         


Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His 
        195                 200                 205             


Gln Gln Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly 
    210                 215                 220                 


Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr 
225                 230                 235                 240 


Tyr Thr Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln 
                245                 250                 255     


Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu 
            260                 265                 270         


Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu 
        275                 280                 285             


Lys His Val Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro 
    290                 295                 300                 


Tyr Val Thr Val Leu Lys Ser Trp Ile Ser Glu Ser Val Glu Ala Asp 
305                 310                 315                 320 


Val Arg Leu Arg Leu Ala Asn Val Ser Glu Arg Asp Gly Gly Glu Tyr 
                325                 330                 335     


Leu Cys Arg Ala Thr Asn Phe Ile Gly Val Ala Glu Lys Ala Phe Trp 
            340                 345                 350         


Leu Ser Val His Gly Pro Arg Ala Ala Glu Glu Glu Leu Val Glu Ala 
        355                 360                 365             


Asp Glu Ala Gly Ser Val Tyr Ala Gly Ile Leu Ser Tyr Gly Val Gly 
    370                 375                 380                 


Phe Phe Leu Phe Ile Leu Val Val Ala Ala Val Thr Leu Cys Arg Leu 
385                 390                 395                 400 


Arg Ser Pro Pro Lys Lys Gly Leu Gly Ser Pro Thr Val His Lys Ile 
                405                 410                 415     


Ser Arg Phe Pro Leu Lys Arg Gln Val Ser Leu Glu Ser Asn Ala Ser 
            420                 425                 430         


Met Ser Ser Asn Thr Pro Leu Val Arg Ile Ala Arg Leu Ser Ser Gly 
        435                 440                 445             


Glu Gly Pro Thr Leu Ala Asn Val Ser Glu Leu Glu Leu Pro Ala Asp 
    450                 455                 460                 


Pro Lys Trp Glu Leu Ser Arg Ala Arg Leu Thr Leu Gly Lys Pro Leu 
465                 470                 475                 480 


Gly Glu Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Ile Gly Ile 
                485                 490                 495     


Asp Lys Asp Arg Ala Ala Lys Pro Val Thr Val Ala Val Lys Met Leu 
            500                 505                 510         


Lys Asp Asp Ala Thr Asp Lys Asp Leu Ser Asp Leu Val Ser Glu Met 
        515                 520                 525             


Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu 
    530                 535                 540                 


Gly Ala Cys Thr Gln Gly Gly Pro Leu Tyr Val Leu Val Glu Tyr Ala 
545                 550                 555                 560 


Ala Lys Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg Pro Pro Gly 
                565                 570                 575     


Leu Asp Tyr Ser Phe Asp Thr Cys Lys Pro Pro Glu Glu Gln Leu Thr 
            580                 585                 590         


Phe Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu 
        595                 600                 605             


Tyr Leu Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn 
    610                 615                 620                 


Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu 
625                 630                 635                 640 


Ala Arg Asp Val His Asn Leu Asp Tyr Tyr Lys Lys Thr Thr Asn Gly 
                645                 650                 655     


Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val 
            660                 665                 670         


Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu 
        675                 680                 685             


Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu 
    690                 695                 700                 


Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn 
705                 710                 715                 720 


Cys Thr His Asp Leu Tyr Met Ile Met Arg Glu Cys Trp His Ala Ala 
                725                 730                 735     


Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg 
            740                 745                 750         


Val Leu Thr Val Thr Ser Thr Asp Glu Tyr Leu Asp Leu Ser Ala Pro 
        755                 760                 765             


Phe Glu Gln Tyr Ser Pro Gly Gly Gln Asp Thr Pro Ser Ser Ser Ser 
    770                 775                 780                 


Ser Gly Asp Asp Ser Val Phe Ala His Asp Leu Leu Pro Pro Ala Pro 
785                 790                 795                 800 


Pro Ser Ser Gly Gly Ser Arg Thr 
                805             


<210>  5348
<211>  806
<212>  PRT
<213>  Homo Sapiens

<400>  5348

Met Gly Ala Pro Ala Cys Ala Leu Ala Leu Cys Val Ala Val Ala Ile 
1               5                   10                  15      


Val Ala Gly Ala Ser Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val 
            20                  25                  30          


Gly Arg Ala Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln 
        35                  40                  45              


Leu Val Phe Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro 
    50                  55                  60                  


Gly Gly Gly Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly 
65                  70                  75                  80  


Leu Val Pro Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val 
                85                  90                  95      


Leu Asn Ala Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg 
            100                 105                 110         


Leu Thr Gln Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala 
        115                 120                 125             


Pro Ser Ser Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr 
    130                 135                 140                 


Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp 
145                 150                 155                 160 


Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys 
                165                 170                 175     


Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly 
            180                 185                 190         


Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His 
        195                 200                 205             


Gln Gln Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly 
    210                 215                 220                 


Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr 
225                 230                 235                 240 


Tyr Thr Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln 
                245                 250                 255     


Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu 
            260                 265                 270         


Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu 
        275                 280                 285             


Lys His Val Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro 
    290                 295                 300                 


Tyr Val Thr Val Leu Lys Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu 
305                 310                 315                 320 


Leu Glu Val Leu Ser Leu His Asn Val Thr Phe Glu Asp Ala Gly Glu 
                325                 330                 335     


Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Phe Ser His His Ser Ala 
            340                 345                 350         


Trp Leu Val Val Leu Pro Ala Glu Glu Glu Leu Val Glu Ala Asp Glu 
        355                 360                 365             


Ala Gly Ser Val Tyr Ala Gly Ile Leu Ser Tyr Gly Val Gly Phe Phe 
    370                 375                 380                 


Leu Phe Ile Leu Val Val Ala Ala Val Thr Leu Cys Arg Leu Arg Ser 
385                 390                 395                 400 


Pro Pro Lys Lys Gly Leu Gly Ser Pro Thr Val His Lys Ile Ser Arg 
                405                 410                 415     


Phe Pro Leu Lys Arg Gln Val Ser Leu Glu Ser Asn Ala Ser Met Ser 
            420                 425                 430         


Ser Asn Thr Pro Leu Val Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly 
        435                 440                 445             


Pro Thr Leu Ala Asn Val Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys 
    450                 455                 460                 


Trp Glu Leu Ser Arg Ala Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu 
465                 470                 475                 480 


Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Ile Gly Ile Asp Lys 
                485                 490                 495     


Asp Arg Ala Ala Lys Pro Val Thr Val Ala Val Lys Met Leu Lys Asp 
            500                 505                 510         


Asp Ala Thr Asp Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met 
        515                 520                 525             


Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala 
    530                 535                 540                 


Cys Thr Gln Gly Gly Pro Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys 
545                 550                 555                 560 


Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg Pro Pro Gly Leu Asp 
                565                 570                 575     


Tyr Ser Phe Asp Thr Cys Lys Pro Pro Glu Glu Gln Leu Thr Phe Lys 
            580                 585                 590         


Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu 
        595                 600                 605             


Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu 
    610                 615                 620                 


Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg 
625                 630                 635                 640 


Asp Val His Asn Leu Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu 
                645                 650                 655     


Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr 
            660                 665                 670         


His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe 
        675                 680                 685             


Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe 
    690                 695                 700                 


Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr 
705                 710                 715                 720 


His Asp Leu Tyr Met Ile Met Arg Glu Cys Trp His Ala Ala Pro Ser 
                725                 730                 735     


Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Val Leu 
            740                 745                 750         


Thr Val Thr Ser Thr Asp Glu Tyr Leu Asp Leu Ser Ala Pro Phe Glu 
        755                 760                 765             


Gln Tyr Ser Pro Gly Gly Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly 
    770                 775                 780                 


Asp Asp Ser Val Phe Ala His Asp Leu Leu Pro Pro Ala Pro Pro Ser 
785                 790                 795                 800 


Ser Gly Gly Ser Arg Thr 
                805     


<210>  5349
<211>  694
<212>  PRT
<213>  Homo Sapiens

<400>  5349

Met Gly Ala Pro Ala Cys Ala Leu Ala Leu Cys Val Ala Val Ala Ile 
1               5                   10                  15      


Val Ala Gly Ala Ser Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val 
            20                  25                  30          


Gly Arg Ala Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln 
        35                  40                  45              


Leu Val Phe Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro 
    50                  55                  60                  


Gly Gly Gly Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly 
65                  70                  75                  80  


Leu Val Pro Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val 
                85                  90                  95      


Leu Asn Ala Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg 
            100                 105                 110         


Leu Thr Gln Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala 
        115                 120                 125             


Pro Ser Ser Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr 
    130                 135                 140                 


Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp 
145                 150                 155                 160 


Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys 
                165                 170                 175     


Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly 
            180                 185                 190         


Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His 
        195                 200                 205             


Gln Gln Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly 
    210                 215                 220                 


Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr 
225                 230                 235                 240 


Tyr Thr Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln 
                245                 250                 255     


Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu 
            260                 265                 270         


Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu 
        275                 280                 285             


Lys His Val Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro 
    290                 295                 300                 


Tyr Val Thr Val Leu Lys Val Ser Leu Glu Ser Asn Ala Ser Met Ser 
305                 310                 315                 320 


Ser Asn Thr Pro Leu Val Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly 
                325                 330                 335     


Pro Thr Leu Ala Asn Val Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys 
            340                 345                 350         


Trp Glu Leu Ser Arg Ala Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu 
        355                 360                 365             


Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Ile Gly Ile Asp Lys 
    370                 375                 380                 


Asp Arg Ala Ala Lys Pro Val Thr Val Ala Val Lys Met Leu Lys Asp 
385                 390                 395                 400 


Asp Ala Thr Asp Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met 
                405                 410                 415     


Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala 
            420                 425                 430         


Cys Thr Gln Gly Gly Pro Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys 
        435                 440                 445             


Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg Pro Pro Gly Leu Asp 
    450                 455                 460                 


Tyr Ser Phe Asp Thr Cys Lys Pro Pro Glu Glu Gln Leu Thr Phe Lys 
465                 470                 475                 480 


Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu 
                485                 490                 495     


Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu 
            500                 505                 510         


Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg 
        515                 520                 525             


Asp Val His Asn Leu Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu 
    530                 535                 540                 


Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr 
545                 550                 555                 560 


His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe 
                565                 570                 575     


Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe 
            580                 585                 590         


Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr 
        595                 600                 605             


His Asp Leu Tyr Met Ile Met Arg Glu Cys Trp His Ala Ala Pro Ser 
    610                 615                 620                 


Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Val Leu 
625                 630                 635                 640 


Thr Val Thr Ser Thr Asp Glu Tyr Leu Asp Leu Ser Ala Pro Phe Glu 
                645                 650                 655     


Gln Tyr Ser Pro Gly Gly Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly 
            660                 665                 670         


Asp Asp Ser Val Phe Ala His Asp Leu Leu Pro Pro Ala Pro Pro Ser 
        675                 680                 685             


Ser Gly Gly Ser Arg Thr 
    690                 


<210>  5350
<211>  792
<212>  PRT
<213>  Homo Sapiens

<400>  5350

Met Gly Ala Pro Ala Cys Ala Leu Ala Leu Cys Val Ala Val Ala Ile 
1               5                   10                  15      


Val Ala Gly Ala Ser Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val 
            20                  25                  30          


Gly Arg Ala Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln 
        35                  40                  45              


Leu Val Phe Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro 
    50                  55                  60                  


Gly Gly Gly Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly 
65                  70                  75                  80  


Leu Val Pro Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val 
                85                  90                  95      


Leu Asn Ala Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg 
            100                 105                 110         


Leu Thr Gln Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala 
        115                 120                 125             


Pro Ser Ser Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr 
    130                 135                 140                 


Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp 
145                 150                 155                 160 


Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys 
                165                 170                 175     


Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly 
            180                 185                 190         


Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His 
        195                 200                 205             


Gln Gln Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly 
    210                 215                 220                 


Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr 
225                 230                 235                 240 


Tyr Thr Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln 
                245                 250                 255     


Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu 
            260                 265                 270         


Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu 
        275                 280                 285             


Lys His Val Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro 
    290                 295                 300                 


Tyr Val Thr Val Leu Lys Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu 
305                 310                 315                 320 


Leu Glu Val Leu Ser Leu His Asn Val Thr Phe Glu Asp Ala Gly Glu 
                325                 330                 335     


Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Phe Ser His His Ser Ala 
            340                 345                 350         


Trp Leu Val Val Leu Pro Ala Glu Glu Glu Leu Val Glu Ala Asp Glu 
        355                 360                 365             


Ala Gly Ser Val Tyr Ala Gly Ile Leu Ser Tyr Gly Val Gly Phe Phe 
    370                 375                 380                 


Leu Phe Ile Leu Val Val Ala Ala Val Thr Leu Cys Arg Leu Arg Ser 
385                 390                 395                 400 


Pro Pro Lys Lys Gly Leu Gly Ser Pro Thr Val His Lys Ile Ser Arg 
                405                 410                 415     


Phe Pro Leu Lys Arg Gln Gln Val Ser Leu Glu Ser Asn Ala Ser Met 
            420                 425                 430         


Ser Ser Asn Thr Pro Leu Val Arg Ile Ala Arg Leu Ser Ser Gly Glu 
        435                 440                 445             


Gly Pro Thr Leu Ala Asn Val Ser Glu Leu Glu Leu Pro Ala Asp Pro 
    450                 455                 460                 


Lys Trp Glu Leu Ser Arg Ala Arg Leu Thr Leu Gly Lys Pro Leu Gly 
465                 470                 475                 480 


Glu Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Ile Gly Ile Asp 
                485                 490                 495     


Lys Asp Arg Ala Ala Lys Pro Val Thr Val Ala Val Lys Met Leu Lys 
            500                 505                 510         


Asp Asp Ala Thr Asp Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu 
        515                 520                 525             


Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly 
    530                 535                 540                 


Ala Cys Thr Gln Gly Gly Pro Leu Tyr Val Leu Val Glu Tyr Ala Ala 
545                 550                 555                 560 


Lys Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg Pro Pro Gly Leu 
                565                 570                 575     


Asp Tyr Ser Phe Asp Thr Cys Lys Pro Pro Glu Glu Gln Leu Thr Phe 
            580                 585                 590         


Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr 
        595                 600                 605             


Leu Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val 
    610                 615                 620                 


Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala 
625                 630                 635                 640 


Arg Asp Val His Asn Leu Asp Tyr Tyr Lys Lys Thr Thr Asn Leu Val 
                645                 650                 655     


Leu Trp Gly Pro Ala Leu Gly Asp Leu His Ala Gly Gly Leu Pro Val 
            660                 665                 670         


Pro Arg His Pro Cys Gly Gly Ala Leu Gln Ala Ala Glu Gly Gly Pro 
        675                 680                 685             


Pro His Gly Gln Ala Arg Gln Leu His Thr Arg Pro Val His Asp His 
    690                 695                 700                 


Ala Gly Val Leu Ala Cys Arg Ala Leu Pro Glu Ala His Leu Gln Ala 
705                 710                 715                 720 


Ala Gly Gly Gly Pro Gly Pro Cys Pro Tyr Arg Asp Val His Arg Arg 
                725                 730                 735     


Val Pro Gly Pro Val Gly Ala Phe Arg Ala Val Leu Pro Gly Trp Pro 
            740                 745                 750         


Gly His Pro Gln Leu Gln Leu Leu Arg Gly Arg Leu Arg Val Cys Pro 
        755                 760                 765             


Arg Pro Ala Ala Pro Gly Pro Thr Gln Gln Trp Gly Leu Ala Asp Val 
    770                 775                 780                 


Lys Gly His Trp Ser Pro Thr Met 
785                 790         


<210>  5351
<211>  364
<212>  PRT
<213>  Homo Sapiens

<400>  5351

Met Gly Ala Pro Ala Cys Ala Leu Ala Leu Cys Val Ala Val Ala Ile 
1               5                   10                  15      


Val Ala Gly Ala Ser Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val 
            20                  25                  30          


Gly Arg Ala Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln 
        35                  40                  45              


Leu Val Phe Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro 
    50                  55                  60                  


Gly Gly Gly Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly 
65                  70                  75                  80  


Leu Val Pro Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val 
                85                  90                  95      


Leu Asn Ala Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg 
            100                 105                 110         


Leu Thr Gln Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala 
        115                 120                 125             


Pro Ser Ser Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr 
    130                 135                 140                 


Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp 
145                 150                 155                 160 


Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys 
                165                 170                 175     


Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly 
            180                 185                 190         


Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His 
        195                 200                 205             


Gln Gln Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly 
    210                 215                 220                 


Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr 
225                 230                 235                 240 


Tyr Thr Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln 
                245                 250                 255     


Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu 
            260                 265                 270         


Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu 
        275                 280                 285             


Lys His Val Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro 
    290                 295                 300                 


Tyr Val Thr Val Leu Lys Ser Trp Ile Ser Glu Ser Val Glu Ala Asp 
305                 310                 315                 320 


Val Arg Leu Arg Leu Ala Asn Val Ser Glu Arg Asp Gly Gly Glu Tyr 
                325                 330                 335     


Leu Cys Arg Ala Thr Asn Phe Ile Gly Val Ala Glu Lys Ala Phe Trp 
            340                 345                 350         


Leu Ser Val His Gly Pro Arg Ala Asp Gly Gly Arg 
        355                 360                 


<210>  5352
<211>  112
<212>  PRT
<213>  Homo Sapiens

<400>  5352

Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg 
1               5                   10                  15      


Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser 
            20                  25                  30          


Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys 
        35                  40                  45              


Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp 
    50                  55                  60                  


Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro 
65                  70                  75                  80  


Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys 
                85                  90                  95      


Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu 
            100                 105                 110         


<210>  5353
<211>  72
<212>  PRT
<213>  Homo Sapiens

<400>  5353

Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly 
1               5                   10                  15      


Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Ala Ser 
            20                  25                  30          


Ile His Leu Ser Leu Cys Leu Arg Glu Arg Thr Gly Leu Ala Gly Arg 
        35                  40                  45              


Arg Ala Leu Ser Trp Ala Ala Glu Leu Val Ser Pro Ala Trp Leu Pro 
    50                  55                  60                  


Ala Trp Ser Ser Lys Ser Arg Ser 
65                  70          


<210>  5354
<211>  87
<212>  PRT
<213>  Homo Sapiens

<400>  5354

Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly 
1               5                   10                  15      


Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro 
            20                  25                  30          


Cys Leu Ala Pro Ser Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala 
        35                  40                  45              


Leu Gly Gln Pro Val Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly 
    50                  55                  60                  


His Trp Tyr Lys Glu Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg 
65                  70                  75                  80  


Gly Trp Arg Gly Arg Leu Glu 
                85          


<210>  5355
<211>  108
<212>  PRT
<213>  Homo Sapiens

<400>  5355

Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly 
1               5                   10                  15      


Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro 
            20                  25                  30          


Cys Leu Ala Pro Ser Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala 
        35                  40                  45              


Leu Gly Gln Pro Val Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly 
    50                  55                  60                  


His Trp Tyr Lys Glu Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg 
65                  70                  75                  80  


Gly Trp Arg Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala 
                85                  90                  95      


Gly Arg Tyr Leu Cys Leu Ala Arg Gly Ser Met Ile 
            100                 105             


<210>  5356
<211>  114
<212>  PRT
<213>  Homo Sapiens

<400>  5356

Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly 
1               5                   10                  15      


Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro 
            20                  25                  30          


Cys Leu Ala Pro Ser Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala 
        35                  40                  45              


Leu Gly Gln Pro Val Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly 
    50                  55                  60                  


His Trp Tyr Lys Glu Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg 
65                  70                  75                  80  


Gly Trp Arg Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala 
                85                  90                  95      


Gly Arg Tyr Leu Cys Leu Ala Arg Gly Ser Met Ile Val Leu Gln Asn 
            100                 105                 110         


Leu Thr 
        


<210>  5357
<211>  201
<212>  PRT
<213>  Homo Sapiens

<400>  5357

Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly 
1               5                   10                  15      


Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro 
            20                  25                  30          


Cys Leu Ala Pro Ser Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala 
        35                  40                  45              


Leu Gly Gln Pro Val Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly 
    50                  55                  60                  


His Trp Tyr Lys Glu Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg 
65                  70                  75                  80  


Gly Trp Arg Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala 
                85                  90                  95      


Gly Arg Tyr Leu Cys Leu Ala Arg Gly Ser Met Ile Val Leu Gln Asn 
            100                 105                 110         


Leu Thr Leu Ile Thr Gly Asp Ser Leu Thr Ser Ser Asn Asp Asp Glu 
        115                 120                 125             


Asp Pro Lys Ser His Arg Asp Pro Ser Asn Arg His Ser Tyr Pro Gln 
    130                 135                 140                 


Gln Ala Pro Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His 
145                 150                 155                 160 


Ala Val Pro Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly 
                165                 170                 175     


Asn Pro Thr Pro Thr Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His 
            180                 185                 190         


Gly Glu Asn Arg Ile Gly Gly Ile Arg 
        195                 200     


<210>  5358
<211>  802
<212>  PRT
<213>  Homo Sapiens

<400>  5358

Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly 
1               5                   10                  15      


Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro 
            20                  25                  30          


Cys Leu Ala Pro Ser Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala 
        35                  40                  45              


Leu Gly Gln Pro Val Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly 
    50                  55                  60                  


His Trp Tyr Lys Glu Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg 
65                  70                  75                  80  


Gly Trp Arg Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala 
                85                  90                  95      


Gly Arg Tyr Leu Cys Leu Ala Arg Gly Ser Met Ile Val Leu Gln Asn 
            100                 105                 110         


Leu Thr Leu Ile Thr Gly Asp Ser Leu Thr Ser Ser Asn Asp Asp Glu 
        115                 120                 125             


Asp Pro Lys Ser His Arg Asp Pro Ser Asn Arg His Ser Tyr Pro Gln 
    130                 135                 140                 


Gln Ala Pro Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His 
145                 150                 155                 160 


Ala Val Pro Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly 
                165                 170                 175     


Asn Pro Thr Pro Thr Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His 
            180                 185                 190         


Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser 
        195                 200                 205             


Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys 
    210                 215                 220                 


Leu Val Glu Asn Ala Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp 
225                 230                 235                 240 


Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro 
                245                 250                 255     


Ala Asn Thr Thr Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys 
            260                 265                 270         


Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val 
        275                 280                 285             


Ile Asn Gly Ser Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val 
    290                 295                 300                 


Leu Lys Thr Ala Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu 
305                 310                 315                 320 


Arg Asn Val Ser Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
                325                 330                 335     


Asn Ser Ile Gly Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro 
            340                 345                 350         


Glu Glu Asp Pro Thr Trp Thr Ala Ala Ala Pro Glu Ala Arg Tyr Thr 
        355                 360                 365             


Asp Ile Ile Leu Tyr Ala Ser Gly Ser Leu Ala Leu Ala Val Leu Leu 
    370                 375                 380                 


Leu Leu Ala Gly Leu Tyr Arg Gly Gln Ala Leu His Gly Arg His Pro 
385                 390                 395                 400 


Arg Pro Pro Ala Thr Val Gln Lys Leu Ser Arg Phe Pro Leu Ala Arg 
                405                 410                 415     


Gln Phe Ser Leu Glu Ser Gly Ser Ser Gly Lys Ser Ser Ser Ser Leu 
            420                 425                 430         


Val Arg Gly Val Arg Leu Ser Ser Ser Gly Pro Ala Leu Leu Ala Gly 
        435                 440                 445             


Leu Val Ser Leu Asp Leu Pro Leu Asp Pro Leu Trp Glu Phe Pro Arg 
    450                 455                 460                 


Asp Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln 
465                 470                 475                 480 


Val Val Arg Ala Glu Ala Phe Gly Met Asp Pro Ala Arg Pro Asp Gln 
                485                 490                 495     


Ala Ser Thr Val Ala Val Lys Met Leu Lys Asp Asn Ala Ser Asp Lys 
            500                 505                 510         


Asp Leu Ala Asp Leu Val Ser Glu Met Glu Val Met Lys Leu Ile Gly 
        515                 520                 525             


Arg His Lys Asn Ile Ile Asn Leu Leu Gly Val Cys Thr Gln Glu Gly 
    530                 535                 540                 


Pro Leu Tyr Val Ile Val Glu Cys Ala Ala Lys Gly Asn Leu Arg Glu 
545                 550                 555                 560 


Phe Leu Arg Ala Arg Arg Pro Pro Gly Pro Asp Leu Ser Pro Asp Gly 
                565                 570                 575     


Pro Arg Ser Ser Glu Gly Pro Leu Ser Phe Pro Val Leu Val Ser Cys 
            580                 585                 590         


Ala Tyr Gln Val Ala Arg Gly Met Gln Tyr Leu Glu Ser Arg Lys Cys 
        595                 600                 605             


Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn 
    610                 615                 620                 


Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Gly Val His His Ile 
625                 630                 635                 640 


Asp Tyr Tyr Lys Lys Thr Ser Asn Gly Arg Leu Pro Val Lys Trp Met 
                645                 650                 655     


Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val 
            660                 665                 670         


Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser 
        675                 680                 685             


Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Ser Leu Leu Arg Glu 
    690                 695                 700                 


Gly His Arg Met Asp Arg Pro Pro His Cys Pro Pro Glu Leu Tyr Gly 
705                 710                 715                 720 


Leu Met Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe 
                725                 730                 735     


Lys Gln Leu Val Glu Ala Leu Asp Lys Val Leu Leu Ala Val Ser Glu 
            740                 745                 750         


Glu Tyr Leu Asp Leu Arg Leu Thr Phe Gly Pro Tyr Ser Pro Ser Gly 
        755                 760                 765             


Gly Asp Ala Ser Ser Thr Cys Ser Ser Ser Asp Ser Val Phe Ser His 
    770                 775                 780                 


Asp Pro Leu Pro Leu Gly Ser Ser Ser Phe Pro Phe Gly Ser Gly Val 
785                 790                 795                 800 


Gln Thr 
        


<210>  5359
<211>  762
<212>  PRT
<213>  Homo Sapiens

<400>  5359

Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly 
1               5                   10                  15      


Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro 
            20                  25                  30          


Cys Leu Ala Pro Ser Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala 
        35                  40                  45              


Leu Gly Gln Pro Val Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly 
    50                  55                  60                  


His Trp Tyr Lys Glu Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg 
65                  70                  75                  80  


Gly Trp Arg Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala 
                85                  90                  95      


Gly Arg Tyr Leu Cys Leu Ala Arg Gly Ser Met Ile Val Leu Gln Asn 
            100                 105                 110         


Leu Thr Leu Ile Thr Gly Asp Ser Leu Thr Ser Ser Asn Asp Asp Glu 
        115                 120                 125             


Asp Pro Lys Ser His Arg Asp Pro Ser Asn Arg His Ser Tyr Pro Gln 
    130                 135                 140                 


Gln Ala Pro Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His 
145                 150                 155                 160 


Ala Val Pro Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly 
                165                 170                 175     


Asn Pro Thr Pro Thr Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His 
            180                 185                 190         


Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser 
        195                 200                 205             


Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys 
    210                 215                 220                 


Leu Val Glu Asn Ala Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp 
225                 230                 235                 240 


Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro 
                245                 250                 255     


Ala Asn Thr Thr Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys 
            260                 265                 270         


Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val 
        275                 280                 285             


Ile Asn Gly Ser Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val 
    290                 295                 300                 


Leu Lys Thr Ala Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu 
305                 310                 315                 320 


Arg Asn Val Ser Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
                325                 330                 335     


Asn Ser Ile Gly Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro 
            340                 345                 350         


Gly Thr Gly Arg Ile Pro His Leu Thr Cys Asp Ser Leu Thr Pro Ala 
        355                 360                 365             


Gly Arg Thr Lys Ser Pro Thr Leu Gln Phe Ser Leu Glu Ser Gly Ser 
    370                 375                 380                 


Ser Gly Lys Ser Ser Ser Ser Leu Val Arg Gly Val Arg Leu Ser Ser 
385                 390                 395                 400 


Ser Gly Pro Ala Leu Leu Ala Gly Leu Val Ser Leu Asp Leu Pro Leu 
                405                 410                 415     


Asp Pro Leu Trp Glu Phe Pro Arg Asp Arg Leu Val Leu Gly Lys Pro 
            420                 425                 430         


Leu Gly Glu Gly Cys Phe Gly Gln Val Val Arg Ala Glu Ala Phe Gly 
        435                 440                 445             


Met Asp Pro Ala Arg Pro Asp Gln Ala Ser Thr Val Ala Val Lys Met 
    450                 455                 460                 


Leu Lys Asp Asn Ala Ser Asp Lys Asp Leu Ala Asp Leu Val Ser Glu 
465                 470                 475                 480 


Met Glu Val Met Lys Leu Ile Gly Arg His Lys Asn Ile Ile Asn Leu 
                485                 490                 495     


Leu Gly Val Cys Thr Gln Glu Gly Pro Leu Tyr Val Ile Val Glu Cys 
            500                 505                 510         


Ala Ala Lys Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg Pro Pro 
        515                 520                 525             


Gly Pro Asp Leu Ser Pro Asp Gly Pro Arg Ser Ser Glu Gly Pro Leu 
    530                 535                 540                 


Ser Phe Pro Val Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met 
545                 550                 555                 560 


Gln Tyr Leu Glu Ser Arg Lys Cys Ile His Arg Asp Leu Ala Ala Arg 
                565                 570                 575     


Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly 
            580                 585                 590         


Leu Ala Arg Gly Val His His Ile Asp Tyr Tyr Lys Lys Thr Ser Asn 
        595                 600                 605             


Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg 
    610                 615                 620                 


Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Trp 
625                 630                 635                 640 


Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu 
                645                 650                 655     


Glu Leu Phe Ser Leu Leu Arg Glu Gly His Arg Met Asp Arg Pro Pro 
            660                 665                 670         


His Cys Pro Pro Glu Leu Tyr Gly Leu Met Arg Glu Cys Trp His Ala 
        675                 680                 685             


Ala Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Ala Leu Asp 
    690                 695                 700                 


Lys Val Leu Leu Ala Val Ser Glu Glu Tyr Leu Asp Leu Arg Leu Thr 
705                 710                 715                 720 


Phe Gly Pro Tyr Ser Pro Ser Gly Gly Asp Ala Ser Ser Thr Cys Ser 
                725                 730                 735     


Ser Ser Asp Ser Val Phe Ser His Asp Pro Leu Pro Leu Gly Ser Ser 
            740                 745                 750         


Ser Phe Pro Phe Gly Ser Gly Val Gln Thr 
        755                 760         


<210>  5360
<211>  734
<212>  PRT
<213>  Homo Sapiens

<400>  5360

Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly 
1               5                   10                  15      


Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro 
            20                  25                  30          


Cys Leu Ala Pro Ser Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala 
        35                  40                  45              


Leu Gly Gln Pro Val Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly 
    50                  55                  60                  


His Trp Tyr Lys Glu Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg 
65                  70                  75                  80  


Gly Trp Arg Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala 
                85                  90                  95      


Gly Arg Tyr Leu Cys Leu Ala Arg Gly Ser Met Ile Val Leu Gln Asn 
            100                 105                 110         


Leu Thr Leu Ile Thr Gly Asp Ser Leu Thr Ser Ser Asn Asp Asp Glu 
        115                 120                 125             


Asp Pro Lys Ser His Arg Asp Pro Ser Asn Arg His Ser Tyr Pro Gln 
    130                 135                 140                 


Gln Ala Pro Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His 
145                 150                 155                 160 


Ala Val Pro Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly 
                165                 170                 175     


Asn Pro Thr Pro Thr Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His 
            180                 185                 190         


Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser 
        195                 200                 205             


Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys 
    210                 215                 220                 


Leu Val Glu Asn Ala Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp 
225                 230                 235                 240 


Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro 
                245                 250                 255     


Ala Asn Thr Thr Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys 
            260                 265                 270         


Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val 
        275                 280                 285             


Ile Asn Gly Ser Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val 
    290                 295                 300                 


Leu Lys Thr Ala Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu 
305                 310                 315                 320 


Arg Asn Val Ser Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
                325                 330                 335     


Asn Ser Ile Gly Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro 
            340                 345                 350         


Glu Glu Asp Pro Thr Trp Thr Ala Ala Ala Pro Glu Ala Ser Ser Pro 
        355                 360                 365             


Trp Ser Gln Ala Leu Pro Ala Ser Gln Ala His Pro Trp Tyr Glu Ala 
    370                 375                 380                 


Cys Val Ser Pro Pro Ala Ala Pro Pro Cys Ser Pro Ala Ser Leu Val 
385                 390                 395                 400 


Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Arg Ala 
                405                 410                 415     


Glu Ala Phe Gly Met Asp Pro Ala Arg Pro Asp Gln Ala Ser Thr Val 
            420                 425                 430         


Ala Val Lys Met Leu Lys Asp Asn Ala Ser Asp Lys Asp Leu Ala Asp 
        435                 440                 445             


Leu Val Ser Glu Met Glu Val Met Lys Leu Ile Gly Arg His Lys Asn 
    450                 455                 460                 


Ile Ile Asn Leu Leu Gly Val Cys Thr Gln Glu Gly Pro Leu Tyr Val 
465                 470                 475                 480 


Ile Val Glu Cys Ala Ala Lys Gly Asn Leu Arg Glu Phe Leu Arg Ala 
                485                 490                 495     


Arg Arg Pro Pro Gly Pro Asp Leu Ser Pro Asp Gly Pro Arg Ser Ser 
            500                 505                 510         


Glu Gly Pro Leu Ser Phe Pro Val Leu Val Ser Cys Ala Tyr Gln Val 
        515                 520                 525             


Ala Arg Gly Met Gln Tyr Leu Glu Ser Arg Lys Cys Ile His Arg Asp 
    530                 535                 540                 


Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile 
545                 550                 555                 560 


Ala Asp Phe Gly Leu Ala Arg Gly Val His His Ile Asp Tyr Tyr Lys 
                565                 570                 575     


Lys Thr Ser Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala 
            580                 585                 590         


Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly 
        595                 600                 605             


Ile Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly 
    610                 615                 620                 


Ile Pro Val Glu Glu Leu Phe Ser Leu Leu Arg Glu Gly His Arg Met 
625                 630                 635                 640 


Asp Arg Pro Pro His Cys Pro Pro Glu Leu Tyr Gly Leu Met Arg Glu 
                645                 650                 655     


Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val 
            660                 665                 670         


Glu Ala Leu Asp Lys Val Leu Leu Ala Val Ser Glu Glu Tyr Leu Asp 
        675                 680                 685             


Leu Arg Leu Thr Phe Gly Pro Tyr Ser Pro Ser Gly Gly Asp Ala Ser 
    690                 695                 700                 


Ser Thr Cys Ser Ser Ser Asp Ser Val Phe Ser His Asp Pro Leu Pro 
705                 710                 715                 720 


Leu Gly Ser Ser Ser Phe Pro Phe Gly Ser Gly Val Gln Thr 
                725                 730                 


<210>  5361
<211>  802
<212>  PRT
<213>  Homo Sapiens

<400>  5361

Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly 
1               5                   10                  15      


Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro 
            20                  25                  30          


Cys Leu Ala Pro Ser Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala 
        35                  40                  45              


Leu Gly Gln Pro Val Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly 
    50                  55                  60                  


His Trp Tyr Lys Glu Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg 
65                  70                  75                  80  


Gly Trp Arg Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala 
                85                  90                  95      


Gly Arg Tyr Leu Cys Leu Ala Arg Gly Ser Met Ile Val Leu Gln Asn 
            100                 105                 110         


Leu Thr Leu Ile Thr Gly Asp Ser Leu Thr Ser Ser Asn Asp Asp Glu 
        115                 120                 125             


Asp Pro Lys Ser His Arg Asp Pro Ser Asn Arg His Ser Tyr Pro Gln 
    130                 135                 140                 


Gln Ala Pro Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His 
145                 150                 155                 160 


Ala Val Pro Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly 
                165                 170                 175     


Asn Pro Thr Pro Thr Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His 
            180                 185                 190         


Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser 
        195                 200                 205             


Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys 
    210                 215                 220                 


Leu Val Glu Asn Ala Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp 
225                 230                 235                 240 


Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro 
                245                 250                 255     


Ala Asn Thr Thr Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys 
            260                 265                 270         


Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val 
        275                 280                 285             


Ile Asn Gly Ser Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val 
    290                 295                 300                 


Leu Lys Thr Ala Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu 
305                 310                 315                 320 


Arg Asn Val Ser Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
                325                 330                 335     


Asn Ser Ile Gly Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro 
            340                 345                 350         


Glu Glu Asp Pro Thr Trp Thr Ala Ala Ala Pro Glu Ala Arg Tyr Thr 
        355                 360                 365             


Asp Ile Ile Leu Tyr Ala Ser Gly Ser Leu Ala Leu Ala Val Leu Leu 
    370                 375                 380                 


Leu Leu Ala Gly Leu Tyr Arg Gly Gln Ala Leu His Gly Arg His Pro 
385                 390                 395                 400 


Arg Pro Pro Ala Thr Val Gln Lys Leu Ser Arg Phe Pro Leu Ala Arg 
                405                 410                 415     


Gln Phe Ser Leu Glu Ser Gly Ser Ser Gly Lys Ser Ser Ser Ser Leu 
            420                 425                 430         


Val Arg Gly Val Arg Leu Ser Ser Ser Gly Pro Ala Leu Leu Ala Gly 
        435                 440                 445             


Leu Val Ser Leu Asp Leu Pro Leu Asp Pro Leu Trp Glu Phe Pro Arg 
    450                 455                 460                 


Asp Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln 
465                 470                 475                 480 


Val Val Arg Ala Glu Ala Phe Gly Met Asp Pro Ala Arg Pro Asp Gln 
                485                 490                 495     


Ala Ser Thr Val Ala Val Lys Met Leu Lys Asp Asn Ala Ser Asp Lys 
            500                 505                 510         


Asp Leu Ala Asp Leu Val Ser Glu Met Glu Val Met Lys Leu Ile Gly 
        515                 520                 525             


Arg His Lys Asn Ile Ile Asn Leu Leu Gly Val Cys Thr Gln Glu Gly 
    530                 535                 540                 


Pro Leu Tyr Val Ile Val Glu Cys Ala Ala Lys Gly Asn Leu Arg Glu 
545                 550                 555                 560 


Phe Leu Arg Ala Arg Arg Pro Pro Gly Pro Asp Leu Ser Pro Asp Gly 
                565                 570                 575     


Pro Arg Ser Ser Glu Gly Pro Leu Ser Phe Pro Val Leu Val Ser Cys 
            580                 585                 590         


Ala Tyr Gln Val Ala Arg Gly Met Gln Tyr Leu Glu Ser Arg Lys Cys 
        595                 600                 605             


Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn 
    610                 615                 620                 


Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Gly Val His His Ile 
625                 630                 635                 640 


Asp Tyr Tyr Lys Lys Thr Ser Asn Gly Arg Leu Pro Val Lys Trp Met 
                645                 650                 655     


Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val 
            660                 665                 670         


Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser 
        675                 680                 685             


Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Ser Leu Leu Arg Glu 
    690                 695                 700                 


Gly His Arg Met Asp Arg Pro Pro His Cys Pro Pro Glu Leu Tyr Gly 
705                 710                 715                 720 


Leu Met Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe 
                725                 730                 735     


Lys Gln Leu Val Glu Ala Leu Asp Lys Val Leu Leu Ala Val Ser Glu 
            740                 745                 750         


Glu Tyr Leu Asp Leu Arg Leu Thr Phe Gly Pro Tyr Ser Pro Ser Gly 
        755                 760                 765             


Gly Asp Ala Ser Ser Thr Cys Ser Ser Ser Asp Ser Val Phe Ser His 
    770                 775                 780                 


Asp Pro Leu Pro Leu Gly Ser Ser Ser Phe Pro Phe Gly Ser Gly Val 
785                 790                 795                 800 


Gln Thr 
        


<210>  5362
<211>  280
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5362

Xaa Arg Tyr Thr Asp Ile Ile Leu Tyr Ala Ser Gly Ser Leu Ala Leu 
1               5                   10                  15      


Ala Val Leu Leu Leu Leu Ala Gly Leu Tyr Arg Gly Gln Ala Leu His 
            20                  25                  30          


Gly Arg His Pro Arg Pro Pro Ala Thr Val Gln Lys Leu Ser Arg Phe 
        35                  40                  45              


Pro Leu Ala Arg Gln Ser Gly Ser Ser Gly Lys Ser Ser Ser Ser Leu 
    50                  55                  60                  


Val Arg Gly Val Arg Leu Ser Ser Ser Gly Pro Ala Leu Leu Ala Gly 
65                  70                  75                  80  


Leu Val Ser Leu Asp Leu Pro Leu Asp Pro Leu Trp Glu Phe Pro Arg 
                85                  90                  95      


Asp Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln 
            100                 105                 110         


Val Val Arg Ala Glu Ala Phe Gly Met Asp Pro Ala Arg Pro Asp Gln 
        115                 120                 125             


Ala Ser Thr Val Ala Val Lys Met Leu Lys Asp Asn Ala Ser Asp Lys 
    130                 135                 140                 


Asp Leu Ala Asp Leu Val Ser Glu Met Glu Val Met Lys Leu Ile Gly 
145                 150                 155                 160 


Arg His Lys Asn Ile Ile Asn Leu Leu Gly Val Cys Thr Gln Glu Gly 
                165                 170                 175     


Pro Leu Tyr Val Ile Val Glu Cys Ala Ala Lys Gly Asn Leu Arg Glu 
            180                 185                 190         


Phe Leu Arg Ala Arg Arg Pro Pro Gly Pro Asp Leu Ser Pro Asp Gly 
        195                 200                 205             


Pro Arg Ser Ser Glu Gly Pro Leu Ser Phe Pro Val Leu Val Ser Cys 
    210                 215                 220                 


Ala Tyr Gln Val Ala Arg Gly Met Gln Tyr Leu Glu Ser Arg Lys Cys 
225                 230                 235                 240 


Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn 
                245                 250                 255     


Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Gly Val His His Ile 
            260                 265                 270         


Asp Tyr Tyr Lys Lys Thr Ser Asn 
        275                 280 


<210>  5363
<211>  80
<212>  PRT
<213>  Homo Sapiens

<400>  5363

Met Thr Pro Ser Pro Leu Leu Leu Leu Leu Leu Pro Pro Leu Leu Leu 
1               5                   10                  15      


Gly Ala Phe Pro Pro Ala Ala Ala Ala Arg Gly Pro Pro Lys Met Ala 
            20                  25                  30          


Asp Lys Val Val Pro Arg Gln Val Ala Arg Leu Gly Arg Thr Val Arg 
        35                  40                  45              


Leu Gln Cys Pro Val Glu Gly Asp Pro Pro Pro Leu Thr Met Trp Thr 
    50                  55                  60                  


Lys Asp Gly Arg Thr Ile His Ser Gly Trp Ser Arg Phe Arg Val Leu 
65                  70                  75                  80  


<210>  5364
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  5364

Met Thr Pro Ser Pro Leu Leu Leu Leu Leu Leu Pro Pro Leu Leu Leu 
1               5                   10                  15      


Gly Ala Phe Pro Pro Ala Ala Ala Ala Arg Gly Pro Pro Lys Met Ala 
            20                  25                  30          


Asp Lys Val Val Pro Arg Gln Val Ala Arg Leu Gly Arg Thr Val Arg 
        35                  40                  45              


Leu Gln Cys Pro Val Glu Gly Asp Pro Pro Pro Leu Thr Met Trp Thr 
    50                  55                  60                  


Lys Asp Gly Arg Thr Ile His Ser Gly Trp Ser Arg Phe Arg Val Leu 
65                  70                  75                  80  


Pro Gln Gly Leu Lys Val Lys Gln Val Glu Arg Glu Asp Ala Gly Val 
                85                  90                  95      


Tyr Val Cys Lys Ala Thr Asn Gly Phe Gly Ser Leu Ser Val Asn Tyr 
            100                 105                 110         


Thr Leu Val Val Leu Asp Asp Ile Ser Pro Gly Lys Glu Ser Leu Gly 
        115                 120                 125             


Pro Asp Ser Ser Ser Gly Gly Gln Glu Asp Pro Ala Ser Gln Gln Trp 
    130                 135                 140                 


Ala Arg Pro Arg Phe Thr Gln Pro 
145                 150         


<210>  5365
<211>  504
<212>  PRT
<213>  Homo Sapiens

<400>  5365

Met Thr Pro Ser Pro Leu Leu Leu Leu Leu Leu Pro Pro Leu Leu Leu 
1               5                   10                  15      


Gly Ala Phe Pro Pro Ala Ala Ala Ala Arg Gly Pro Pro Lys Met Ala 
            20                  25                  30          


Asp Lys Val Val Pro Arg Gln Val Ala Arg Leu Gly Arg Thr Val Arg 
        35                  40                  45              


Leu Gln Cys Pro Val Glu Gly Asp Pro Pro Pro Leu Thr Met Trp Thr 
    50                  55                  60                  


Lys Asp Gly Arg Thr Ile His Ser Gly Trp Ser Arg Phe Arg Val Leu 
65                  70                  75                  80  


Pro Gln Gly Leu Lys Val Lys Gln Val Glu Arg Glu Asp Ala Gly Val 
                85                  90                  95      


Tyr Val Cys Lys Ala Thr Asn Gly Phe Gly Ser Leu Ser Val Asn Tyr 
            100                 105                 110         


Thr Leu Val Val Leu Asp Asp Ile Ser Pro Gly Lys Glu Ser Leu Gly 
        115                 120                 125             


Pro Asp Ser Ser Ser Gly Gly Gln Glu Asp Pro Ala Ser Gln Gln Trp 
    130                 135                 140                 


Ala Arg Pro Arg Phe Thr Gln Pro Ser Lys Met Arg Arg Arg Val Ile 
145                 150                 155                 160 


Ala Arg Pro Val Gly Ser Ser Val Arg Leu Lys Cys Val Ala Ser Gly 
                165                 170                 175     


His Pro Arg Pro Asp Ile Thr Trp Met Lys Asp Asp Gln Ala Leu Thr 
            180                 185                 190         


Arg Pro Glu Ala Ala Glu Pro Arg Lys Lys Lys Trp Thr Leu Ser Leu 
        195                 200                 205             


Lys Asn Leu Arg Pro Glu Asp Ser Gly Lys Tyr Thr Cys Arg Val Ser 
    210                 215                 220                 


Asn Arg Ala Gly Ala Ile Asn Ala Thr Tyr Lys Val Asp Val Ile Gln 
225                 230                 235                 240 


Arg Thr Arg Ser Lys Pro Val Leu Thr Gly Thr His Pro Val Asn Thr 
                245                 250                 255     


Thr Val Asp Phe Gly Gly Thr Thr Ser Phe Gln Cys Lys Val Arg Ser 
            260                 265                 270         


Asp Val Lys Pro Val Ile Gln Trp Leu Lys Arg Val Glu Tyr Gly Ala 
        275                 280                 285             


Glu Gly Arg His Asn Ser Thr Ile Asp Val Gly Gly Gln Lys Phe Val 
    290                 295                 300                 


Val Leu Pro Thr Gly Asp Val Trp Ser Arg Pro Asp Gly Ser Tyr Leu 
305                 310                 315                 320 


Asn Lys Leu Leu Ile Thr Arg Ala Arg Gln Asp Asp Ala Gly Met Tyr 
                325                 330                 335     


Ile Cys Leu Gly Ala Asn Thr Met Gly Tyr Ser Phe Arg Ser Ala Phe 
            340                 345                 350         


Leu Thr Val Leu Pro Asp Pro Lys Pro Pro Gly Pro Pro Val Ala Ser 
        355                 360                 365             


Ser Ser Ser Ala Thr Ser Leu Pro Trp Pro Val Val Ile Gly Ile Pro 
    370                 375                 380                 


Ala Gly Ala Val Phe Ile Leu Gly Thr Leu Leu Leu Trp Leu Cys Gln 
385                 390                 395                 400 


Ala Gln Lys Lys Pro Cys Thr Pro Ala Pro Ala Pro Pro Leu Pro Gly 
                405                 410                 415     


His Arg Pro Pro Gly Thr Ala Arg Asp Arg Ser Gly Asp Lys Asp Leu 
            420                 425                 430         


Pro Ser Leu Ala Ala Leu Ser Ala Gly Pro Gly Val Gly Leu Cys Glu 
        435                 440                 445             


Glu His Gly Ser Pro Ala Ala Pro Gln His Leu Leu Gly Pro Gly Pro 
    450                 455                 460                 


Val Ala Gly Pro Lys Leu Tyr Pro Lys Leu Tyr Thr Asp Ile His Thr 
465                 470                 475                 480 


His Thr His Thr His Ser His Thr His Ser His Val Glu Gly Lys Val 
                485                 490                 495     


His Gln His Ile His Tyr Gln Cys 
            500                 


<210>  5366
<211>  504
<212>  PRT
<213>  Homo Sapiens

<400>  5366

Met Thr Pro Ser Pro Leu Leu Leu Leu Leu Leu Pro Pro Leu Leu Leu 
1               5                   10                  15      


Gly Ala Phe Pro Pro Ala Ala Ala Ala Arg Gly Pro Pro Lys Met Ala 
            20                  25                  30          


Asp Lys Val Val Pro Arg Gln Val Ala Arg Leu Gly Arg Thr Val Arg 
        35                  40                  45              


Leu Gln Cys Pro Val Glu Gly Asp Pro Pro Pro Leu Thr Met Trp Thr 
    50                  55                  60                  


Lys Asp Gly Arg Thr Ile His Ser Gly Trp Ser Arg Phe Arg Val Leu 
65                  70                  75                  80  


Pro Gln Gly Leu Lys Val Lys Gln Val Glu Arg Glu Asp Ala Gly Val 
                85                  90                  95      


Tyr Val Cys Lys Ala Thr Asn Gly Phe Gly Ser Leu Ser Val Asn Tyr 
            100                 105                 110         


Thr Leu Val Val Leu Asp Asp Ile Ser Pro Gly Lys Glu Ser Leu Gly 
        115                 120                 125             


Pro Asp Ser Ser Ser Gly Gly Gln Glu Asp Pro Ala Ser Gln Gln Trp 
    130                 135                 140                 


Ala Arg Pro Arg Phe Thr Gln Pro Ser Lys Met Arg Arg Arg Val Ile 
145                 150                 155                 160 


Ala Arg Pro Val Gly Ser Ser Val Arg Leu Lys Cys Val Ala Ser Gly 
                165                 170                 175     


His Pro Arg Pro Asp Ile Thr Trp Met Lys Asp Asp Gln Ala Leu Thr 
            180                 185                 190         


Arg Pro Glu Ala Ala Glu Pro Arg Lys Lys Lys Trp Thr Leu Ser Leu 
        195                 200                 205             


Lys Asn Leu Arg Pro Glu Asp Ser Gly Lys Tyr Thr Cys Arg Val Ser 
    210                 215                 220                 


Asn Arg Ala Gly Ala Ile Asn Ala Thr Tyr Lys Val Asp Val Ile Gln 
225                 230                 235                 240 


Arg Thr Arg Ser Lys Pro Val Leu Thr Gly Thr His Pro Val Asn Thr 
                245                 250                 255     


Thr Val Asp Phe Gly Gly Thr Thr Ser Phe Gln Cys Lys Val Arg Ser 
            260                 265                 270         


Asp Val Lys Pro Val Ile Gln Trp Leu Lys Arg Val Glu Tyr Gly Ala 
        275                 280                 285             


Glu Gly Arg His Asn Ser Thr Ile Asp Val Gly Gly Gln Lys Phe Val 
    290                 295                 300                 


Val Leu Pro Thr Gly Asp Val Trp Ser Arg Pro Asp Gly Ser Tyr Leu 
305                 310                 315                 320 


Asn Lys Leu Leu Ile Thr Arg Ala Arg Gln Asp Asp Ala Gly Met Tyr 
                325                 330                 335     


Ile Cys Leu Gly Ala Asn Thr Met Gly Tyr Ser Phe Arg Ser Ala Phe 
            340                 345                 350         


Leu Thr Val Leu Pro Asp Pro Lys Pro Pro Gly Pro Pro Val Ala Ser 
        355                 360                 365             


Ser Ser Ser Ala Thr Ser Leu Pro Trp Pro Val Val Ile Gly Ile Pro 
    370                 375                 380                 


Ala Gly Ala Val Phe Ile Leu Gly Thr Leu Leu Leu Trp Leu Cys Gln 
385                 390                 395                 400 


Ala Gln Lys Lys Pro Cys Thr Pro Ala Pro Ala Pro Pro Leu Pro Gly 
                405                 410                 415     


His Arg Pro Pro Gly Thr Ala Arg Asp Arg Ser Gly Asp Lys Asp Leu 
            420                 425                 430         


Pro Ser Leu Ala Ala Leu Ser Ala Gly Pro Gly Val Gly Leu Cys Glu 
        435                 440                 445             


Glu His Gly Ser Pro Ala Ala Pro Gln His Leu Leu Gly Pro Gly Pro 
    450                 455                 460                 


Val Ala Gly Pro Lys Leu Tyr Pro Lys Leu Tyr Thr Asp Ile His Thr 
465                 470                 475                 480 


His Thr His Thr His Ser His Thr His Ser His Val Glu Gly Lys Val 
                485                 490                 495     


His Gln His Ile His Tyr Gln Cys 
            500                 


<210>  5367
<211>  504
<212>  PRT
<213>  Homo Sapiens

<400>  5367

Met Thr Pro Ser Pro Leu Leu Leu Leu Leu Leu Pro Pro Leu Leu Leu 
1               5                   10                  15      


Gly Ala Phe Pro Pro Ala Ala Ala Ala Arg Gly Pro Pro Lys Met Ala 
            20                  25                  30          


Asp Lys Val Val Pro Arg Gln Val Ala Arg Leu Gly Arg Thr Val Arg 
        35                  40                  45              


Leu Gln Cys Pro Val Glu Gly Asp Pro Pro Pro Leu Thr Met Trp Thr 
    50                  55                  60                  


Lys Asp Gly Arg Thr Ile His Ser Gly Trp Ser Arg Phe Arg Val Leu 
65                  70                  75                  80  


Pro Gln Gly Leu Lys Val Lys Gln Val Glu Arg Glu Asp Ala Gly Val 
                85                  90                  95      


Tyr Val Cys Lys Ala Thr Asn Gly Phe Gly Ser Leu Ser Val Asn Tyr 
            100                 105                 110         


Thr Leu Val Val Leu Asp Asp Ile Ser Pro Gly Lys Glu Ser Leu Gly 
        115                 120                 125             


Pro Asp Ser Ser Ser Gly Gly Gln Glu Asp Pro Ala Ser Gln Gln Trp 
    130                 135                 140                 


Ala Arg Pro Arg Phe Thr Gln Pro Ser Lys Met Arg Arg Arg Val Ile 
145                 150                 155                 160 


Ala Arg Pro Val Gly Ser Ser Val Arg Leu Lys Cys Val Ala Ser Gly 
                165                 170                 175     


His Pro Arg Pro Asp Ile Thr Trp Met Lys Asp Asp Gln Ala Leu Thr 
            180                 185                 190         


Arg Pro Glu Ala Ala Glu Pro Arg Lys Lys Lys Trp Thr Leu Ser Leu 
        195                 200                 205             


Lys Asn Leu Arg Pro Glu Asp Ser Gly Lys Tyr Thr Cys Arg Val Ser 
    210                 215                 220                 


Asn Arg Ala Gly Ala Ile Asn Ala Thr Tyr Lys Val Asp Val Ile Gln 
225                 230                 235                 240 


Arg Thr Arg Ser Lys Pro Val Leu Thr Gly Thr His Pro Val Asn Thr 
                245                 250                 255     


Thr Val Asp Phe Gly Gly Thr Thr Ser Phe Gln Cys Lys Val Arg Ser 
            260                 265                 270         


Asp Val Lys Pro Val Ile Gln Trp Leu Lys Arg Val Glu Tyr Gly Ala 
        275                 280                 285             


Glu Gly Arg His Asn Ser Thr Ile Asp Val Gly Gly Gln Lys Phe Val 
    290                 295                 300                 


Val Leu Pro Thr Gly Asp Val Trp Ser Arg Pro Asp Gly Ser Tyr Leu 
305                 310                 315                 320 


Asn Lys Leu Leu Ile Thr Arg Ala Arg Gln Asp Asp Ala Gly Met Tyr 
                325                 330                 335     


Ile Cys Leu Gly Ala Asn Thr Met Gly Tyr Ser Phe Arg Ser Ala Phe 
            340                 345                 350         


Leu Thr Val Leu Pro Asp Pro Lys Pro Pro Gly Pro Pro Val Ala Ser 
        355                 360                 365             


Ser Ser Ser Ala Thr Ser Leu Pro Trp Pro Val Val Ile Gly Ile Pro 
    370                 375                 380                 


Ala Gly Ala Val Phe Ile Leu Gly Thr Leu Leu Leu Trp Leu Cys Gln 
385                 390                 395                 400 


Ala Gln Lys Lys Pro Cys Thr Pro Ala Pro Ala Pro Pro Leu Pro Gly 
                405                 410                 415     


His Arg Pro Pro Gly Thr Ala Arg Asp Arg Ser Gly Asp Lys Asp Leu 
            420                 425                 430         


Pro Ser Leu Ala Ala Leu Ser Ala Gly Pro Gly Val Gly Leu Cys Glu 
        435                 440                 445             


Glu His Gly Ser Pro Ala Ala Pro Gln His Leu Leu Gly Pro Gly Pro 
    450                 455                 460                 


Val Ala Gly Pro Lys Leu Tyr Pro Lys Leu Tyr Thr Asp Ile His Thr 
465                 470                 475                 480 


His Thr His Thr His Ser His Thr His Ser His Val Glu Gly Lys Val 
                485                 490                 495     


His Gln His Ile His Tyr Gln Cys 
            500                 


<210>  5368
<211>  504
<212>  PRT
<213>  Homo Sapiens

<400>  5368

Met Thr Pro Ser Pro Leu Leu Leu Leu Leu Leu Pro Pro Leu Leu Leu 
1               5                   10                  15      


Gly Ala Phe Pro Pro Ala Ala Ala Ala Arg Gly Pro Pro Lys Met Ala 
            20                  25                  30          


Asp Lys Val Val Pro Arg Gln Val Ala Arg Leu Gly Arg Thr Val Arg 
        35                  40                  45              


Leu Gln Cys Pro Val Glu Gly Asp Pro Pro Pro Leu Thr Met Trp Thr 
    50                  55                  60                  


Lys Asp Gly Arg Thr Ile His Ser Gly Trp Ser Arg Phe Arg Val Leu 
65                  70                  75                  80  


Pro Gln Gly Leu Lys Val Lys Gln Val Glu Arg Glu Asp Ala Gly Val 
                85                  90                  95      


Tyr Val Cys Lys Ala Thr Asn Gly Phe Gly Ser Leu Ser Val Asn Tyr 
            100                 105                 110         


Thr Leu Val Val Leu Asp Asp Ile Ser Pro Gly Lys Glu Ser Leu Gly 
        115                 120                 125             


Pro Asp Ser Ser Ser Gly Gly Gln Glu Asp Pro Ala Ser Gln Gln Trp 
    130                 135                 140                 


Ala Arg Pro Arg Phe Thr Gln Pro Ser Lys Met Arg Arg Arg Val Ile 
145                 150                 155                 160 


Ala Arg Pro Val Gly Ser Ser Val Arg Leu Lys Cys Val Ala Ser Gly 
                165                 170                 175     


His Pro Arg Pro Asp Ile Thr Trp Met Lys Asp Asp Gln Ala Leu Thr 
            180                 185                 190         


Arg Pro Glu Ala Ala Glu Pro Arg Lys Lys Lys Trp Thr Leu Ser Leu 
        195                 200                 205             


Lys Asn Leu Arg Pro Glu Asp Ser Gly Lys Tyr Thr Cys Arg Val Ser 
    210                 215                 220                 


Asn Arg Ala Gly Ala Ile Asn Ala Thr Tyr Lys Val Asp Val Ile Gln 
225                 230                 235                 240 


Arg Thr Arg Ser Lys Pro Val Leu Thr Gly Thr His Pro Val Asn Thr 
                245                 250                 255     


Thr Val Asp Phe Gly Gly Thr Thr Ser Phe Gln Cys Lys Val Arg Ser 
            260                 265                 270         


Asp Val Lys Pro Val Ile Gln Trp Leu Lys Arg Val Glu Tyr Gly Ala 
        275                 280                 285             


Glu Gly Arg His Asn Ser Thr Ile Asp Val Gly Gly Gln Lys Phe Val 
    290                 295                 300                 


Val Leu Pro Thr Gly Asp Val Trp Ser Arg Pro Asp Gly Ser Tyr Leu 
305                 310                 315                 320 


Asn Lys Leu Leu Ile Thr Arg Ala Arg Gln Asp Asp Ala Gly Met Tyr 
                325                 330                 335     


Ile Cys Leu Gly Ala Asn Thr Met Gly Tyr Ser Phe Arg Ser Ala Phe 
            340                 345                 350         


Leu Thr Val Leu Pro Asp Pro Lys Pro Pro Gly Pro Pro Val Ala Ser 
        355                 360                 365             


Ser Ser Ser Ala Thr Ser Leu Pro Trp Pro Val Val Ile Gly Ile Pro 
    370                 375                 380                 


Ala Gly Ala Val Phe Ile Leu Gly Thr Leu Leu Leu Trp Leu Cys Gln 
385                 390                 395                 400 


Ala Gln Lys Lys Pro Cys Thr Pro Ala Pro Ala Pro Pro Leu Pro Gly 
                405                 410                 415     


His Arg Pro Pro Gly Thr Ala Arg Asp Arg Ser Gly Asp Lys Asp Leu 
            420                 425                 430         


Pro Ser Leu Ala Ala Leu Ser Ala Gly Pro Gly Val Gly Leu Cys Glu 
        435                 440                 445             


Glu His Gly Ser Pro Ala Ala Pro Gln His Leu Leu Gly Pro Gly Pro 
    450                 455                 460                 


Val Ala Gly Pro Lys Leu Tyr Pro Lys Leu Tyr Thr Asp Ile His Thr 
465                 470                 475                 480 


His Thr His Thr His Ser His Thr His Ser His Val Glu Gly Lys Val 
                485                 490                 495     


His Gln His Ile His Tyr Gln Cys 
            500                 


<210>  5369
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  5369

Met Ile Asp Ala Ala Thr Leu Lys Ser Arg Lys Met Leu Glu Glu Ile 
1               5                   10                  15      


Met Lys Tyr Glu Ala Ser Ile Leu Thr His Asp Ser Ser Ile Arg Tyr 
            20                  25                  30          


Leu Gln Glu Ile Tyr Asn Ser Asn Asn Gln Lys Ile Val Asn Leu Lys 
        35                  40                  45              


Glu Lys Val Ala Gln Leu Glu Ala Gln Cys Gln Glu Pro Cys Lys Asp 
    50                  55                  60                  


Thr Val Gln Ile His Asp Ile Thr Gly Lys Asp Cys Gln Asp Ile Ala 
65                  70                  75                  80  


Asn Lys Gly Ala Lys Gln Ser Gly Leu Tyr Phe Ile Lys Pro Leu Lys 
                85                  90                  95      


Ala Asn Gln Gln Phe Leu Val Tyr Cys Glu Ile Asp Gly Ser Gly Asn 
            100                 105                 110         


Gly Trp Thr Val Phe Gln Lys 
        115                 


<210>  5370
<211>  123
<212>  PRT
<213>  Homo Sapiens

<400>  5370

Met Ile Asp Ala Ala Thr Leu Lys Ser Arg Lys Met Leu Glu Glu Ile 
1               5                   10                  15      


Met Lys Tyr Glu Ala Ser Ile Leu Thr His Asp Ser Ser Ile Arg Tyr 
            20                  25                  30          


Leu Gln Glu Ile Tyr Asn Ser Asn Asn Gln Lys Ile Val Asn Leu Lys 
        35                  40                  45              


Glu Lys Val Ala Gln Leu Glu Ala Gln Cys Gln Glu Pro Cys Lys Asp 
    50                  55                  60                  


Thr Val Gln Ile His Asp Ile Thr Gly Lys Asp Cys Gln Asp Ile Ala 
65                  70                  75                  80  


Asn Lys Gly Ala Lys Gln Ser Gly Leu Tyr Phe Ile Lys Pro Leu Lys 
                85                  90                  95      


Ala Asn Gln Gln Phe Leu Val Tyr Cys Glu Ile Asp Gly Ser Gly Asn 
            100                 105                 110         


Gly Trp Thr Val Phe Gln Lys Arg Leu Asp Gly 
        115                 120             


<210>  5371
<211>  453
<212>  PRT
<213>  Homo Sapiens

<400>  5371

Met Ser Trp Ser Leu His Pro Arg Asn Leu Ile Leu Tyr Phe Tyr Ala 
1               5                   10                  15      


Leu Leu Phe Leu Ser Ser Thr Cys Val Ala Tyr Val Ala Thr Arg Asp 
            20                  25                  30          


Asn Cys Cys Ile Leu Asp Glu Arg Phe Gly Ser Tyr Cys Pro Thr Thr 
        35                  40                  45              


Cys Gly Ile Ala Asp Phe Leu Ser Thr Tyr Gln Thr Lys Val Asp Lys 
    50                  55                  60                  


Asp Leu Gln Ser Leu Glu Asp Ile Leu His Gln Val Glu Asn Lys Thr 
65                  70                  75                  80  


Ser Glu Val Lys Gln Leu Ile Lys Ala Ile Gln Leu Thr Tyr Asn Pro 
                85                  90                  95      


Asp Glu Ser Ser Lys Pro Asn Met Ile Asp Ala Ala Thr Leu Lys Ser 
            100                 105                 110         


Arg Lys Met Leu Glu Glu Ile Met Lys Tyr Glu Ala Ser Ile Leu Thr 
        115                 120                 125             


His Asp Ser Ser Ile Arg Tyr Leu Gln Glu Ile Tyr Asn Ser Asn Asn 
    130                 135                 140                 


Gln Lys Ile Val Asn Leu Lys Glu Lys Val Ala Gln Leu Glu Ala Gln 
145                 150                 155                 160 


Cys Gln Glu Pro Cys Lys Asp Thr Val Gln Ile His Asp Ile Thr Gly 
                165                 170                 175     


Lys Asp Cys Gln Asp Ile Ala Asn Lys Gly Ala Lys Gln Ser Gly Leu 
            180                 185                 190         


Tyr Phe Ile Lys Pro Leu Lys Ala Asn Gln Gln Phe Leu Val Tyr Cys 
        195                 200                 205             


Glu Ile Asp Gly Ser Gly Asn Gly Trp Thr Val Phe Gln Lys Arg Leu 
    210                 215                 220                 


Asp Gly Ser Val Asp Phe Lys Lys Asn Trp Ile Gln Tyr Lys Glu Gly 
225                 230                 235                 240 


Phe Gly His Leu Ser Pro Thr Gly Thr Thr Glu Phe Trp Leu Gly Asn 
                245                 250                 255     


Glu Lys Ile His Leu Ile Ser Thr Gln Ser Ala Ile Pro Tyr Ala Leu 
            260                 265                 270         


Arg Val Glu Leu Glu Asp Trp Asn Gly Arg Thr Ser Thr Ala Asp Tyr 
        275                 280                 285             


Ala Met Phe Lys Val Gly Pro Glu Ala Asp Lys Tyr Arg Leu Thr Tyr 
    290                 295                 300                 


Ala Tyr Phe Ala Gly Gly Asp Ala Gly Asp Ala Phe Asp Gly Phe Asp 
305                 310                 315                 320 


Phe Gly Asp Asp Pro Ser Asp Lys Phe Phe Thr Ser His Asn Gly Met 
                325                 330                 335     


Gln Phe Ser Thr Trp Asp Asn Asp Asn Asp Lys Phe Glu Gly Asn Cys 
            340                 345                 350         


Ala Glu Gln Asp Gly Ser Gly Trp Trp Met Asn Lys Cys His Ala Gly 
        355                 360                 365             


His Leu Asn Gly Val Tyr Tyr Gln Gly Gly Thr Tyr Ser Lys Ala Ser 
    370                 375                 380                 


Thr Pro Asn Gly Tyr Asp Asn Gly Ile Ile Trp Ala Thr Trp Lys Thr 
385                 390                 395                 400 


Arg Trp Tyr Ser Met Lys Lys Thr Thr Met Lys Ile Ile Pro Phe Asn 
                405                 410                 415     


Arg Leu Thr Ile Gly Glu Gly Gln Gln His His Leu Gly Gly Ala Lys 
            420                 425                 430         


Gln Val Arg Pro Glu His Pro Ala Glu Thr Glu Tyr Asp Ser Leu Tyr 
        435                 440                 445             


Pro Glu Asp Asp Leu 
    450             


<210>  5372
<211>  437
<212>  PRT
<213>  Homo Sapiens

<400>  5372

Met Ser Trp Ser Leu His Pro Arg Asn Leu Ile Leu Tyr Phe Tyr Ala 
1               5                   10                  15      


Leu Leu Phe Leu Ser Ser Thr Cys Val Ala Tyr Val Ala Thr Arg Asp 
            20                  25                  30          


Asn Cys Cys Ile Leu Asp Glu Arg Phe Gly Ser Tyr Cys Pro Thr Thr 
        35                  40                  45              


Cys Gly Ile Ala Asp Phe Leu Ser Thr Tyr Gln Thr Lys Val Asp Lys 
    50                  55                  60                  


Asp Leu Gln Ser Leu Glu Asp Ile Leu His Gln Val Glu Asn Lys Thr 
65                  70                  75                  80  


Ser Glu Val Lys Gln Leu Ile Lys Ala Ile Gln Leu Thr Tyr Asn Pro 
                85                  90                  95      


Asp Glu Ser Ser Lys Pro Asn Met Ile Asp Ala Ala Thr Leu Lys Ser 
            100                 105                 110         


Arg Lys Met Leu Glu Glu Ile Met Lys Tyr Glu Ala Ser Ile Leu Thr 
        115                 120                 125             


His Asp Ser Ser Ile Arg Tyr Leu Gln Glu Ile Tyr Asn Ser Asn Asn 
    130                 135                 140                 


Gln Lys Ile Val Asn Leu Lys Glu Lys Val Ala Gln Leu Glu Ala Gln 
145                 150                 155                 160 


Cys Gln Glu Pro Cys Lys Asp Thr Val Gln Ile His Asp Ile Thr Gly 
                165                 170                 175     


Lys Asp Cys Gln Asp Ile Ala Asn Lys Gly Ala Lys Gln Ser Gly Leu 
            180                 185                 190         


Tyr Phe Ile Lys Pro Leu Lys Ala Asn Gln Gln Phe Leu Val Tyr Cys 
        195                 200                 205             


Glu Ile Asp Gly Ser Gly Asn Gly Trp Thr Val Phe Gln Lys Arg Leu 
    210                 215                 220                 


Asp Gly Ser Val Asp Phe Lys Lys Asn Trp Ile Gln Tyr Lys Glu Gly 
225                 230                 235                 240 


Phe Gly His Leu Ser Pro Thr Gly Thr Thr Glu Phe Trp Leu Gly Asn 
                245                 250                 255     


Glu Lys Ile His Leu Ile Ser Thr Gln Ser Ala Ile Pro Tyr Ala Leu 
            260                 265                 270         


Arg Val Glu Leu Glu Asp Trp Asn Gly Arg Thr Ser Thr Ala Asp Tyr 
        275                 280                 285             


Ala Met Phe Lys Val Gly Pro Glu Ala Asp Lys Tyr Arg Leu Thr Tyr 
    290                 295                 300                 


Ala Tyr Phe Ala Gly Gly Asp Ala Gly Asp Ala Phe Asp Gly Phe Asp 
305                 310                 315                 320 


Phe Gly Asp Asp Pro Ser Asp Lys Phe Phe Thr Ser His Asn Gly Met 
                325                 330                 335     


Gln Phe Ser Thr Trp Asp Asn Asp Asn Asp Lys Phe Glu Gly Asn Cys 
            340                 345                 350         


Ala Glu Gln Asp Gly Ser Gly Trp Trp Met Asn Lys Cys His Ala Gly 
        355                 360                 365             


His Leu Asn Gly Val Tyr Tyr Gln Gly Gly Thr Tyr Ser Lys Ala Ser 
    370                 375                 380                 


Thr Pro Asn Gly Tyr Asp Asn Gly Ile Ile Trp Ala Thr Trp Lys Thr 
385                 390                 395                 400 


Arg Trp Tyr Ser Met Lys Lys Thr Thr Met Lys Ile Ile Pro Phe Asn 
                405                 410                 415     


Arg Leu Thr Ile Gly Glu Gly Gln Gln His His Leu Gly Gly Ala Lys 
            420                 425                 430         


Gln Ala Gly Asp Val 
        435         


<210>  5373
<211>  461
<212>  PRT
<213>  Homo Sapiens

<400>  5373

Met Ser Trp Ser Leu His Pro Arg Asn Leu Ile Leu Tyr Phe Tyr Ala 
1               5                   10                  15      


Leu Leu Phe Leu Ser Ser Thr Cys Val Ala Tyr Val Ala Thr Arg Asp 
            20                  25                  30          


Asn Cys Cys Ile Leu Asp Glu Arg Phe Gly Ser Tyr Cys Pro Thr Thr 
        35                  40                  45              


Cys Gly Ile Ala Asp Phe Leu Ser Thr Tyr Gln Thr Lys Val Asp Lys 
    50                  55                  60                  


Asp Leu Gln Ser Leu Glu Asp Ile Leu His Gln Val Glu Asn Lys Thr 
65                  70                  75                  80  


Ser Glu Val Lys Gln Leu Ile Lys Ala Ile Gln Leu Thr Tyr Asn Pro 
                85                  90                  95      


Asp Glu Ser Ser Lys Pro Asn Met Ile Asp Ala Ala Thr Leu Lys Ser 
            100                 105                 110         


Arg Lys Met Leu Glu Glu Ile Met Lys Tyr Glu Ala Ser Ile Leu Thr 
        115                 120                 125             


His Asp Ser Ser Ile Arg Tyr Leu Gln Glu Ile Tyr Asn Ser Asn Asn 
    130                 135                 140                 


Gln Lys Ile Val Asn Leu Lys Glu Lys Val Ala Gln Leu Glu Ala Gln 
145                 150                 155                 160 


Cys Gln Glu Pro Cys Lys Asp Thr Val Gln Ile His Asp Ile Thr Gly 
                165                 170                 175     


Lys Val Lys Val Asp Ser Pro Ser Leu Asp Cys Gln Asp Ile Ala Asn 
            180                 185                 190         


Lys Gly Ala Lys Gln Ser Gly Leu Tyr Phe Ile Lys Pro Leu Lys Ala 
        195                 200                 205             


Asn Gln Gln Phe Leu Val Tyr Cys Glu Ile Asp Gly Ser Gly Asn Gly 
    210                 215                 220                 


Trp Thr Val Phe Gln Lys Arg Leu Asp Gly Ser Val Asp Phe Lys Lys 
225                 230                 235                 240 


Asn Trp Ile Gln Tyr Lys Glu Gly Phe Gly His Leu Ser Pro Thr Gly 
                245                 250                 255     


Thr Thr Glu Phe Trp Leu Gly Asn Glu Lys Ile His Leu Ile Ser Thr 
            260                 265                 270         


Gln Ser Ala Ile Pro Tyr Ala Leu Arg Val Glu Leu Glu Asp Trp Asn 
        275                 280                 285             


Gly Arg Thr Ser Thr Ala Asp Tyr Ala Met Phe Lys Val Gly Pro Glu 
    290                 295                 300                 


Ala Asp Lys Tyr Arg Leu Thr Tyr Ala Tyr Phe Ala Gly Gly Asp Ala 
305                 310                 315                 320 


Gly Asp Ala Phe Asp Gly Phe Asp Phe Gly Asp Asp Pro Ser Asp Lys 
                325                 330                 335     


Phe Phe Thr Ser His Asn Gly Met Gln Phe Ser Thr Trp Asp Asn Asp 
            340                 345                 350         


Asn Asp Lys Phe Glu Gly Asn Cys Ala Glu Gln Asp Gly Ser Gly Trp 
        355                 360                 365             


Trp Met Asn Lys Cys His Ala Gly His Leu Asn Gly Val Tyr Tyr Gln 
    370                 375                 380                 


Gly Gly Thr Tyr Ser Lys Ala Ser Thr Pro Asn Gly Tyr Asp Asn Gly 
385                 390                 395                 400 


Ile Ile Trp Ala Thr Trp Lys Thr Arg Trp Tyr Ser Met Lys Lys Thr 
                405                 410                 415     


Thr Met Lys Ile Ile Pro Phe Asn Arg Leu Thr Ile Gly Glu Gly Gln 
            420                 425                 430         


Gln His His Leu Gly Gly Ala Lys Gln Val Arg Pro Glu His Pro Ala 
        435                 440                 445             


Glu Thr Glu Tyr Asp Ser Leu Tyr Pro Glu Asp Asp Leu 
    450                 455                 460     


<210>  5374
<211>  445
<212>  PRT
<213>  Homo Sapiens

<400>  5374

Met Ser Trp Ser Leu His Pro Arg Asn Leu Ile Leu Tyr Phe Tyr Ala 
1               5                   10                  15      


Leu Leu Phe Leu Ser Ser Thr Cys Val Ala Tyr Val Ala Thr Arg Asp 
            20                  25                  30          


Asn Cys Cys Ile Leu Asp Glu Arg Phe Gly Ser Tyr Cys Pro Thr Thr 
        35                  40                  45              


Cys Gly Ile Ala Asp Phe Leu Ser Thr Tyr Gln Thr Lys Val Asp Lys 
    50                  55                  60                  


Asp Leu Gln Ser Leu Glu Asp Ile Leu His Gln Val Glu Asn Lys Thr 
65                  70                  75                  80  


Ser Glu Val Lys Gln Leu Ile Lys Ala Ile Gln Leu Thr Tyr Asn Pro 
                85                  90                  95      


Asp Glu Ser Ser Lys Pro Asn Met Ile Asp Ala Ala Thr Leu Lys Ser 
            100                 105                 110         


Arg Lys Met Leu Glu Glu Ile Met Lys Tyr Glu Ala Ser Ile Leu Thr 
        115                 120                 125             


His Asp Ser Ser Ile Arg Tyr Leu Gln Glu Ile Tyr Asn Ser Asn Asn 
    130                 135                 140                 


Gln Lys Ile Val Asn Leu Lys Glu Lys Val Ala Gln Leu Glu Ala Gln 
145                 150                 155                 160 


Cys Gln Glu Pro Cys Lys Asp Thr Val Gln Ile His Asp Ile Thr Gly 
                165                 170                 175     


Lys Val Lys Val Asp Ser Pro Ser Leu Asp Cys Gln Asp Ile Ala Asn 
            180                 185                 190         


Lys Gly Ala Lys Gln Ser Gly Leu Tyr Phe Ile Lys Pro Leu Lys Ala 
        195                 200                 205             


Asn Gln Gln Phe Leu Val Tyr Cys Glu Ile Asp Gly Ser Gly Asn Gly 
    210                 215                 220                 


Trp Thr Val Phe Gln Lys Arg Leu Asp Gly Ser Val Asp Phe Lys Lys 
225                 230                 235                 240 


Asn Trp Ile Gln Tyr Lys Glu Gly Phe Gly His Leu Ser Pro Thr Gly 
                245                 250                 255     


Thr Thr Glu Phe Trp Leu Gly Asn Glu Lys Ile His Leu Ile Ser Thr 
            260                 265                 270         


Gln Ser Ala Ile Pro Tyr Ala Leu Arg Val Glu Leu Glu Asp Trp Asn 
        275                 280                 285             


Gly Arg Thr Ser Thr Ala Asp Tyr Ala Met Phe Lys Val Gly Pro Glu 
    290                 295                 300                 


Ala Asp Lys Tyr Arg Leu Thr Tyr Ala Tyr Phe Ala Gly Gly Asp Ala 
305                 310                 315                 320 


Gly Asp Ala Phe Asp Gly Phe Asp Phe Gly Asp Asp Pro Ser Asp Lys 
                325                 330                 335     


Phe Phe Thr Ser His Asn Gly Met Gln Phe Ser Thr Trp Asp Asn Asp 
            340                 345                 350         


Asn Asp Lys Phe Glu Gly Asn Cys Ala Glu Gln Asp Gly Ser Gly Trp 
        355                 360                 365             


Trp Met Asn Lys Cys His Ala Gly His Leu Asn Gly Val Tyr Tyr Gln 
    370                 375                 380                 


Gly Gly Thr Tyr Ser Lys Ala Ser Thr Pro Asn Gly Tyr Asp Asn Gly 
385                 390                 395                 400 


Ile Ile Trp Ala Thr Trp Lys Thr Arg Trp Tyr Ser Met Lys Lys Thr 
                405                 410                 415     


Thr Met Lys Ile Ile Pro Phe Asn Arg Leu Thr Ile Gly Glu Gly Gln 
            420                 425                 430         


Gln His His Leu Gly Gly Ala Lys Gln Ala Gly Asp Val 
        435                 440                 445 


<210>  5375
<211>  312
<212>  PRT
<213>  Homo Sapiens

<400>  5375

Met Ala Lys Val Phe Ser Phe Ile Leu Val Thr Thr Ala Leu Thr Met 
1               5                   10                  15      


Gly Arg Glu Ile Ser Ala Leu Glu Asp Cys Ala Gln Glu Gln Met Arg 
            20                  25                  30          


Leu Arg Ala Gln Val Arg Leu Leu Glu Thr Arg Val Lys Gln Gln Gln 
        35                  40                  45              


Val Lys Ile Lys Gln Leu Leu Gln Glu Asn Glu Val Gln Phe Leu Asp 
    50                  55                  60                  


Lys Gly Asp Glu Asn Thr Val Ile Asp Leu Gly Ser Lys Arg Gln Tyr 
65                  70                  75                  80  


Ala Asp Cys Ser Glu Ile Phe Asn Asp Gly Tyr Lys Leu Ser Gly Phe 
                85                  90                  95      


Tyr Lys Ile Lys Pro Leu Gln Ser Pro Ala Glu Phe Ser Val Tyr Cys 
            100                 105                 110         


Asp Met Ser Asp Gly Gly Gly Trp Thr Val Ile Gln Arg Arg Ser Asp 
        115                 120                 125             


Gly Ser Glu Asn Phe Asn Arg Gly Trp Lys Asp Tyr Glu Asn Gly Phe 
    130                 135                 140                 


Gly Asn Phe Val Gln Lys His Gly Glu Tyr Trp Leu Gly Asn Lys Asn 
145                 150                 155                 160 


Leu His Phe Leu Thr Thr Gln Glu Asp Tyr Thr Leu Lys Ile Asp Leu 
                165                 170                 175     


Ala Asp Phe Glu Lys Asn Ser Arg Tyr Ala Gln Tyr Lys Asn Phe Lys 
            180                 185                 190         


Val Gly Asp Glu Lys Asn Phe Tyr Glu Leu Asn Ile Gly Glu Tyr Ser 
        195                 200                 205             


Gly Thr Ala Gly Asp Ser Leu Ala Gly Asn Phe His Pro Glu Val Gln 
    210                 215                 220                 


Trp Trp Ala Ser His Gln Arg Met Lys Phe Ser Thr Trp Asp Arg Asp 
225                 230                 235                 240 


His Asp Asn Tyr Glu Gly Asn Cys Ala Glu Glu Asp Gln Ser Gly Trp 
                245                 250                 255     


Trp Phe Asn Arg Cys His Ser Ala Asn Leu Asn Gly Val Tyr Tyr Ser 
            260                 265                 270         


Gly Pro Tyr Thr Ala Lys Thr Asp Asn Gly Ile Val Trp Tyr Thr Trp 
        275                 280                 285             


His Gly Trp Trp Tyr Ser Leu Lys Ser Val Val Met Lys Ile Arg Pro 
    290                 295                 300                 


Asn Asp Phe Ile Pro Asn Val Ile 
305                 310         


<210>  5376
<211>  312
<212>  PRT
<213>  Homo Sapiens

<400>  5376

Met Ala Lys Val Phe Ser Phe Ile Leu Val Thr Thr Ala Leu Thr Met 
1               5                   10                  15      


Gly Arg Glu Ile Ser Ala Leu Glu Asp Cys Ala Gln Glu Gln Met Arg 
            20                  25                  30          


Leu Arg Ala Gln Val Arg Leu Leu Glu Thr Arg Val Lys Gln Gln Gln 
        35                  40                  45              


Val Lys Ile Lys Gln Leu Leu Gln Glu Asn Glu Val Gln Phe Leu Asp 
    50                  55                  60                  


Lys Gly Asp Glu Asn Thr Val Ile Asp Leu Gly Ser Lys Arg Gln Tyr 
65                  70                  75                  80  


Ala Asp Cys Ser Glu Ile Phe Asn Asp Gly Tyr Lys Leu Ser Gly Phe 
                85                  90                  95      


Tyr Lys Ile Lys Pro Leu Gln Ser Pro Ala Glu Phe Ser Val Tyr Cys 
            100                 105                 110         


Asp Met Ser Asp Gly Gly Gly Trp Thr Val Ile Gln Arg Arg Ser Asp 
        115                 120                 125             


Gly Ser Glu Asn Phe Asn Arg Gly Trp Lys Asp Tyr Glu Asn Gly Phe 
    130                 135                 140                 


Gly Asn Phe Val Gln Lys His Gly Glu Tyr Trp Leu Gly Asn Lys Asn 
145                 150                 155                 160 


Leu His Phe Leu Thr Thr Gln Glu Asp Tyr Thr Leu Lys Ile Asp Leu 
                165                 170                 175     


Ala Asp Phe Glu Lys Asn Ser Arg Tyr Ala Gln Tyr Lys Asn Phe Lys 
            180                 185                 190         


Val Gly Asp Glu Lys Asn Phe Tyr Glu Leu Asn Ile Gly Glu Tyr Ser 
        195                 200                 205             


Gly Thr Ala Gly Asp Ser Leu Ala Gly Asn Phe His Pro Glu Val Gln 
    210                 215                 220                 


Trp Trp Ala Ser His Gln Arg Met Lys Phe Ser Thr Trp Asp Arg Asp 
225                 230                 235                 240 


His Asp Asn Tyr Glu Gly Asn Cys Ala Glu Glu Asp Gln Ser Gly Trp 
                245                 250                 255     


Trp Phe Asn Arg Cys His Ser Ala Asn Leu Asn Gly Val Tyr Tyr Ser 
            260                 265                 270         


Gly Pro Tyr Thr Ala Lys Thr Asp Asn Gly Ile Val Trp Tyr Thr Trp 
        275                 280                 285             


His Gly Trp Trp Tyr Ser Leu Lys Ser Val Val Met Lys Ile Arg Pro 
    290                 295                 300                 


Asn Asp Phe Ile Pro Asn Val Ile 
305                 310         


<210>  5377
<211>  312
<212>  PRT
<213>  Homo Sapiens

<400>  5377

Met Ala Lys Val Phe Ser Phe Ile Leu Val Thr Thr Ala Leu Thr Met 
1               5                   10                  15      


Gly Arg Glu Ile Ser Ala Leu Glu Asp Cys Ala Gln Glu Gln Met Arg 
            20                  25                  30          


Leu Arg Ala Gln Val Arg Leu Leu Glu Thr Arg Val Lys Gln Gln Gln 
        35                  40                  45              


Val Lys Ile Lys Gln Leu Leu Gln Glu Asn Glu Val Gln Phe Leu Asp 
    50                  55                  60                  


Lys Gly Asp Glu Asn Thr Val Ile Asp Leu Gly Ser Lys Arg Gln Tyr 
65                  70                  75                  80  


Ala Asp Cys Ser Glu Ile Phe Asn Asp Gly Tyr Lys Leu Ser Gly Phe 
                85                  90                  95      


Tyr Lys Ile Lys Pro Leu Gln Ser Pro Ala Glu Phe Ser Val Tyr Cys 
            100                 105                 110         


Asp Met Ser Asp Gly Gly Gly Trp Thr Val Ile Gln Arg Arg Ser Asp 
        115                 120                 125             


Gly Ser Glu Asn Phe Asn Arg Gly Trp Lys Asp Tyr Glu Asn Gly Phe 
    130                 135                 140                 


Gly Asn Phe Val Gln Lys His Gly Glu Tyr Trp Leu Gly Asn Lys Asn 
145                 150                 155                 160 


Leu His Phe Leu Thr Thr Gln Glu Asp Tyr Thr Leu Lys Ile Asp Leu 
                165                 170                 175     


Ala Asp Phe Glu Lys Asn Ser Arg Tyr Ala Gln Tyr Lys Asn Phe Lys 
            180                 185                 190         


Val Gly Asp Glu Lys Asn Phe Tyr Glu Leu Asn Ile Gly Glu Tyr Ser 
        195                 200                 205             


Gly Thr Ala Gly Asp Ser Leu Ala Gly Asn Phe His Pro Glu Val Gln 
    210                 215                 220                 


Trp Trp Ala Ser His Gln Arg Met Lys Phe Ser Thr Trp Asp Arg Asp 
225                 230                 235                 240 


His Asp Asn Tyr Glu Gly Asn Cys Ala Glu Glu Asp Gln Ser Gly Trp 
                245                 250                 255     


Trp Phe Asn Arg Cys His Ser Ala Asn Leu Asn Gly Val Tyr Tyr Ser 
            260                 265                 270         


Gly Pro Tyr Thr Ala Lys Thr Asp Asn Gly Ile Val Trp Tyr Thr Trp 
        275                 280                 285             


His Gly Trp Trp Tyr Ser Leu Lys Ser Val Val Met Lys Ile Arg Pro 
    290                 295                 300                 


Asn Asp Phe Ile Pro Asn Val Ile 
305                 310         


<210>  5378
<211>  312
<212>  PRT
<213>  Homo Sapiens

<400>  5378

Met Ala Lys Val Phe Ser Phe Ile Leu Val Thr Thr Ala Leu Thr Met 
1               5                   10                  15      


Gly Arg Glu Ile Ser Ala Leu Glu Asp Cys Ala Gln Glu Gln Met Arg 
            20                  25                  30          


Leu Arg Ala Gln Val Arg Leu Leu Glu Thr Arg Val Lys Gln Gln Gln 
        35                  40                  45              


Val Lys Ile Lys Gln Leu Leu Gln Glu Asn Glu Val Gln Phe Leu Asp 
    50                  55                  60                  


Lys Gly Asp Glu Asn Thr Val Ile Asp Leu Gly Ser Lys Arg Gln Tyr 
65                  70                  75                  80  


Ala Asp Cys Ser Glu Ile Phe Asn Asp Gly Tyr Lys Leu Ser Gly Phe 
                85                  90                  95      


Tyr Lys Ile Lys Pro Leu Gln Ser Pro Ala Glu Phe Ser Val Tyr Cys 
            100                 105                 110         


Asp Met Ser Asp Gly Gly Gly Trp Thr Val Ile Gln Arg Arg Ser Asp 
        115                 120                 125             


Gly Ser Glu Asn Phe Asn Arg Gly Trp Lys Asp Tyr Glu Asn Gly Phe 
    130                 135                 140                 


Gly Asn Phe Val Gln Lys His Gly Glu Tyr Trp Leu Gly Asn Lys Asn 
145                 150                 155                 160 


Leu His Phe Leu Thr Thr Gln Glu Asp Tyr Thr Leu Lys Ile Asp Leu 
                165                 170                 175     


Ala Asp Phe Glu Lys Asn Ser Arg Tyr Ala Gln Tyr Lys Asn Phe Lys 
            180                 185                 190         


Val Gly Asp Glu Lys Asn Phe Tyr Glu Leu Asn Ile Gly Glu Tyr Ser 
        195                 200                 205             


Gly Thr Ala Gly Asp Ser Leu Ala Gly Asn Phe His Pro Glu Val Gln 
    210                 215                 220                 


Trp Trp Ala Ser His Gln Arg Met Lys Phe Ser Thr Trp Asp Arg Asp 
225                 230                 235                 240 


His Asp Asn Tyr Glu Gly Asn Cys Ala Glu Glu Asp Gln Ser Gly Trp 
                245                 250                 255     


Trp Phe Asn Arg Cys His Ser Ala Asn Leu Asn Gly Val Tyr Tyr Ser 
            260                 265                 270         


Gly Pro Tyr Thr Ala Lys Thr Asp Asn Gly Ile Val Trp Tyr Thr Trp 
        275                 280                 285             


His Gly Trp Trp Tyr Ser Leu Lys Ser Val Val Met Lys Ile Arg Pro 
    290                 295                 300                 


Asn Asp Phe Ile Pro Asn Val Ile 
305                 310         


<210>  5379
<211>  312
<212>  PRT
<213>  Homo Sapiens

<400>  5379

Met Ala Lys Val Phe Ser Phe Ile Leu Val Thr Thr Ala Leu Thr Met 
1               5                   10                  15      


Gly Arg Glu Ile Ser Ala Leu Glu Asp Cys Ala Gln Glu Gln Met Arg 
            20                  25                  30          


Leu Arg Ala Gln Val Arg Leu Leu Glu Thr Arg Val Lys Gln Gln Gln 
        35                  40                  45              


Val Lys Ile Lys Gln Leu Leu Gln Glu Asn Glu Val Gln Phe Leu Asp 
    50                  55                  60                  


Lys Gly Asp Glu Asn Thr Val Ile Asp Leu Gly Ser Lys Arg Gln Tyr 
65                  70                  75                  80  


Ala Asp Cys Ser Glu Ile Phe Asn Asp Gly Tyr Lys Leu Ser Gly Phe 
                85                  90                  95      


Tyr Lys Ile Lys Pro Leu Gln Ser Pro Ala Glu Phe Ser Val Tyr Cys 
            100                 105                 110         


Asp Met Ser Asp Gly Gly Gly Trp Thr Val Ile Gln Arg Arg Ser Asp 
        115                 120                 125             


Gly Ser Glu Asn Phe Asn Arg Gly Trp Lys Asp Tyr Glu Asn Gly Phe 
    130                 135                 140                 


Gly Asn Phe Val Gln Lys His Gly Glu Tyr Trp Leu Gly Asn Lys Asn 
145                 150                 155                 160 


Leu His Phe Leu Thr Thr Gln Glu Asp Tyr Thr Leu Lys Ile Asp Leu 
                165                 170                 175     


Ala Asp Phe Glu Lys Asn Ser Arg Tyr Ala Gln Tyr Lys Asn Phe Lys 
            180                 185                 190         


Val Gly Asp Glu Lys Asn Phe Tyr Glu Leu Asn Ile Gly Glu Tyr Ser 
        195                 200                 205             


Gly Thr Ala Gly Asp Ser Leu Ala Gly Asn Phe His Pro Glu Val Gln 
    210                 215                 220                 


Trp Trp Ala Ser His Gln Arg Met Lys Phe Ser Thr Trp Asp Arg Asp 
225                 230                 235                 240 


His Asp Asn Tyr Glu Gly Asn Cys Ala Glu Glu Asp Gln Ser Gly Trp 
                245                 250                 255     


Trp Phe Asn Arg Cys His Ser Ala Asn Leu Asn Gly Val Tyr Tyr Ser 
            260                 265                 270         


Gly Pro Tyr Thr Ala Lys Thr Asp Asn Gly Ile Val Trp Tyr Thr Trp 
        275                 280                 285             


His Gly Trp Trp Tyr Ser Leu Lys Ser Val Val Met Lys Ile Arg Pro 
    290                 295                 300                 


Asn Asp Phe Ile Pro Asn Val Ile 
305                 310         


<210>  5380
<211>  312
<212>  PRT
<213>  Homo Sapiens

<400>  5380

Met Ala Lys Val Phe Ser Phe Ile Leu Val Thr Thr Ala Leu Thr Met 
1               5                   10                  15      


Gly Arg Glu Ile Ser Ala Leu Glu Asp Cys Ala Gln Glu Gln Met Arg 
            20                  25                  30          


Leu Arg Ala Gln Val Arg Leu Leu Glu Thr Arg Val Lys Gln Gln Gln 
        35                  40                  45              


Val Lys Ile Lys Gln Leu Leu Gln Glu Asn Glu Val Gln Phe Leu Asp 
    50                  55                  60                  


Lys Gly Asp Glu Asn Thr Val Ile Asp Leu Gly Ser Lys Arg Gln Tyr 
65                  70                  75                  80  


Ala Asp Cys Ser Glu Ile Phe Asn Asp Gly Tyr Lys Leu Ser Gly Phe 
                85                  90                  95      


Tyr Lys Ile Lys Pro Leu Gln Ser Pro Ala Glu Phe Ser Val Tyr Cys 
            100                 105                 110         


Asp Met Ser Asp Gly Gly Gly Trp Thr Val Ile Gln Arg Arg Ser Asp 
        115                 120                 125             


Gly Ser Glu Asn Phe Asn Arg Gly Trp Lys Asp Tyr Glu Asn Gly Phe 
    130                 135                 140                 


Gly Asn Phe Val Gln Lys His Gly Glu Tyr Trp Leu Gly Asn Lys Asn 
145                 150                 155                 160 


Leu His Phe Leu Thr Thr Gln Glu Asp Tyr Thr Leu Lys Ile Asp Leu 
                165                 170                 175     


Ala Asp Phe Glu Lys Asn Ser Arg Tyr Ala Gln Tyr Lys Asn Phe Lys 
            180                 185                 190         


Val Gly Asp Glu Lys Asn Phe Tyr Glu Leu Asn Ile Gly Glu Tyr Ser 
        195                 200                 205             


Gly Thr Ala Gly Asp Ser Leu Ala Gly Asn Phe His Pro Glu Val Gln 
    210                 215                 220                 


Trp Trp Ala Ser His Gln Arg Met Lys Phe Ser Thr Trp Asp Arg Asp 
225                 230                 235                 240 


His Asp Asn Tyr Glu Gly Asn Cys Ala Glu Glu Asp Gln Ser Gly Trp 
                245                 250                 255     


Trp Phe Asn Arg Cys His Ser Ala Asn Leu Asn Gly Val Tyr Tyr Ser 
            260                 265                 270         


Gly Pro Tyr Thr Ala Lys Thr Asp Asn Gly Ile Val Trp Tyr Thr Trp 
        275                 280                 285             


His Gly Trp Trp Tyr Ser Leu Lys Ser Val Val Met Lys Ile Arg Pro 
    290                 295                 300                 


Asn Asp Phe Ile Pro Asn Val Ile 
305                 310         


<210>  5381
<211>  312
<212>  PRT
<213>  Homo Sapiens

<400>  5381

Met Ala Lys Val Phe Ser Phe Ile Leu Val Thr Thr Ala Leu Thr Met 
1               5                   10                  15      


Gly Arg Glu Ile Ser Ala Leu Glu Asp Cys Ala Gln Glu Gln Met Arg 
            20                  25                  30          


Leu Arg Ala Gln Val Arg Leu Leu Glu Thr Arg Val Lys Gln Gln Gln 
        35                  40                  45              


Val Lys Ile Lys Gln Leu Leu Gln Glu Asn Glu Val Gln Phe Leu Asp 
    50                  55                  60                  


Lys Gly Asp Glu Asn Thr Val Ile Asp Leu Gly Ser Lys Arg Gln Tyr 
65                  70                  75                  80  


Ala Asp Cys Ser Glu Ile Phe Asn Asp Gly Tyr Lys Leu Ser Gly Phe 
                85                  90                  95      


Tyr Lys Ile Lys Pro Leu Gln Ser Pro Ala Glu Phe Ser Val Tyr Cys 
            100                 105                 110         


Asp Met Ser Asp Gly Gly Gly Trp Thr Val Ile Gln Arg Arg Ser Asp 
        115                 120                 125             


Gly Ser Glu Asn Phe Asn Arg Gly Trp Lys Asp Tyr Glu Asn Gly Phe 
    130                 135                 140                 


Gly Asn Phe Val Gln Lys His Gly Glu Tyr Trp Leu Gly Asn Lys Asn 
145                 150                 155                 160 


Leu His Phe Leu Thr Thr Gln Glu Asp Tyr Thr Leu Lys Ile Asp Leu 
                165                 170                 175     


Ala Asp Phe Glu Lys Asn Ser Arg Tyr Ala Gln Tyr Lys Asn Phe Lys 
            180                 185                 190         


Val Gly Asp Glu Lys Asn Phe Tyr Glu Leu Asn Ile Gly Glu Tyr Ser 
        195                 200                 205             


Gly Thr Ala Gly Asp Ser Leu Ala Gly Asn Phe His Pro Glu Val Gln 
    210                 215                 220                 


Trp Trp Ala Ser His Gln Arg Met Lys Phe Ser Thr Trp Asp Arg Asp 
225                 230                 235                 240 


His Asp Asn Tyr Glu Gly Asn Cys Ala Glu Glu Asp Gln Ser Gly Trp 
                245                 250                 255     


Trp Phe Asn Arg Cys His Ser Ala Asn Leu Asn Gly Val Tyr Tyr Ser 
            260                 265                 270         


Gly Pro Tyr Thr Ala Lys Thr Asp Asn Gly Ile Val Trp Tyr Thr Trp 
        275                 280                 285             


His Gly Trp Trp Tyr Ser Leu Lys Ser Val Val Met Lys Ile Arg Pro 
    290                 295                 300                 


Asn Asp Phe Ile Pro Asn Val Ile 
305                 310         


<210>  5382
<211>  225
<212>  PRT
<213>  Homo Sapiens

<400>  5382

Met Lys Leu Ala Asn Trp Tyr Trp Leu Ser Ser Ala Val Leu Ala Thr 
1               5                   10                  15      


Tyr Gly Phe Leu Val Val Ala Asn Asn Glu Thr Glu Glu Ile Lys Asp 
            20                  25                  30          


Glu Arg Ala Lys Asp Val Cys Pro Val Arg Leu Glu Ser Arg Gly Lys 
        35                  40                  45              


Cys Glu Glu Ala Gly Glu Cys Pro Tyr Gln Val Ser Leu Pro Pro Leu 
    50                  55                  60                  


Thr Ile Gln Leu Pro Lys Gln Phe Ser Arg Ile Glu Glu Val Phe Lys 
65                  70                  75                  80  


Glu Val Gln Asn Leu Lys Glu Ile Val Asn Ser Leu Lys Lys Ser Cys 
                85                  90                  95      


Gln Asp Cys Lys Leu Gln Ala Asp Asp Asn Gly Asp Pro Gly Arg Asn 
            100                 105                 110         


Gly Leu Leu Leu Pro Ser Thr Gly Ala Pro Gly Glu Val Gly Asp Asn 
        115                 120                 125             


Arg Val Arg Glu Leu Glu Ser Glu Val Asn Lys Leu Ser Ser Glu Leu 
    130                 135                 140                 


Lys Asn Ala Lys Glu Glu Ile Asn Val Leu His Gly Arg Leu Glu Lys 
145                 150                 155                 160 


Leu Asn Leu Val Asn Met Asn Asn Ile Glu Asn Tyr Val Asp Ser Lys 
                165                 170                 175     


Val Ala Asn Leu Thr Phe Val Val Asn Ser Leu Asp Gly Lys Cys Ser 
            180                 185                 190         


Lys Cys Pro Ser Gln Glu Gln Ile Gln Ser Arg Pro Gly Met Tyr Asn 
        195                 200                 205             


Asn Val Phe Leu Ser Tyr Val His Lys Cys Tyr Thr Ala Arg Glu Tyr 
    210                 215                 220                 


Leu 
225 


<210>  5383
<211>  439
<212>  PRT
<213>  Homo Sapiens

<400>  5383

Met Lys Leu Ala Asn Trp Tyr Trp Leu Ser Ser Ala Val Leu Ala Thr 
1               5                   10                  15      


Tyr Gly Phe Leu Val Val Ala Asn Asn Glu Thr Glu Glu Ile Lys Asp 
            20                  25                  30          


Glu Arg Ala Lys Asp Val Cys Pro Val Arg Leu Glu Ser Arg Gly Lys 
        35                  40                  45              


Cys Glu Glu Ala Gly Glu Cys Pro Tyr Gln Val Ser Leu Pro Pro Leu 
    50                  55                  60                  


Thr Ile Gln Leu Pro Lys Gln Phe Ser Arg Ile Glu Glu Val Phe Lys 
65                  70                  75                  80  


Glu Val Gln Asn Leu Lys Glu Ile Val Asn Ser Leu Lys Lys Ser Cys 
                85                  90                  95      


Gln Asp Cys Lys Leu Gln Ala Asp Asp Asn Gly Asp Pro Gly Arg Asn 
            100                 105                 110         


Gly Leu Leu Leu Pro Ser Thr Gly Ala Pro Gly Glu Val Gly Asp Asn 
        115                 120                 125             


Arg Val Arg Glu Leu Glu Ser Glu Val Asn Lys Leu Ser Ser Glu Leu 
    130                 135                 140                 


Lys Asn Ala Lys Glu Glu Ile Asn Val Leu His Gly Arg Leu Glu Lys 
145                 150                 155                 160 


Leu Asn Leu Val Asn Met Asn Asn Ile Glu Asn Tyr Val Asp Ser Lys 
                165                 170                 175     


Val Ala Asn Leu Thr Phe Val Val Asn Ser Leu Asp Gly Lys Cys Ser 
            180                 185                 190         


Lys Cys Pro Ser Gln Glu Gln Ile Gln Ser Arg Pro Val Gln His Leu 
        195                 200                 205             


Ile Tyr Lys Asp Cys Ser Asp Tyr Tyr Ala Ile Gly Lys Arg Ser Ser 
    210                 215                 220                 


Glu Thr Tyr Arg Val Thr Pro Asp Pro Lys Asn Ser Ser Phe Glu Val 
225                 230                 235                 240 


Tyr Cys Asp Met Glu Thr Met Gly Gly Gly Trp Thr Val Leu Gln Ala 
                245                 250                 255     


Arg Leu Asp Gly Ser Thr Asn Phe Thr Arg Thr Trp Gln Asp Tyr Lys 
            260                 265                 270         


Ala Gly Phe Gly Asn Leu Arg Arg Glu Phe Trp Leu Gly Asn Asp Lys 
        275                 280                 285             


Ile His Leu Leu Thr Lys Ser Lys Glu Met Ile Leu Arg Ile Asp Leu 
    290                 295                 300                 


Glu Asp Phe Asn Gly Val Glu Leu Tyr Ala Leu Tyr Asp Gln Phe Tyr 
305                 310                 315                 320 


Val Ala Asn Glu Phe Leu Lys Tyr Arg Leu His Val Gly Asn Tyr Asn 
                325                 330                 335     


Gly Thr Ala Gly Asp Ala Leu Arg Phe Asn Lys His Tyr Asn His Asp 
            340                 345                 350         


Leu Lys Phe Phe Thr Thr Pro Asp Lys Asp Asn Asp Arg Tyr Pro Ser 
        355                 360                 365             


Gly Asn Cys Gly Leu Tyr Tyr Ser Ser Gly Trp Trp Phe Asp Ala Cys 
    370                 375                 380                 


Leu Ser Ala Asn Leu Asn Gly Lys Tyr Tyr His Gln Lys Tyr Arg Gly 
385                 390                 395                 400 


Val Arg Asn Gly Ile Phe Trp Gly Thr Trp Pro Gly Val Ser Glu Ala 
                405                 410                 415     


His Pro Gly Gly Tyr Lys Ser Ser Phe Lys Glu Ala Lys Met Met Ile 
            420                 425                 430         


Arg Pro Lys His Phe Lys Pro 
        435                 


<210>  5384
<211>  18
<212>  PRT
<213>  Homo Sapiens

<400>  5384

Met Ala Glu Lys Phe Asp Cys His Tyr Cys Arg Asp Pro Leu Gln Gly 
1               5                   10                  15      


Lys Lys 
        


<210>  5385
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  5385

Met Ala Glu Lys Phe Asp Cys His Tyr Cys Arg Asp Pro Leu Gln Gly 
1               5                   10                  15      


Lys Lys Tyr Val Gln Lys Asp Gly His His Cys Cys Leu Lys Cys Phe 
            20                  25                  30          


Asp Lys Phe Cys Ala Asn Thr Cys Val Glu Cys Arg Lys Pro Ile Gly 
        35                  40                  45              


Ala Asp Ser Lys Glu Val His Tyr Lys Asn Arg Phe Trp His Asp Thr 
    50                  55                  60                  


Cys Phe 
65      


<210>  5386
<211>  78
<212>  PRT
<213>  Homo Sapiens

<400>  5386

Met Ala Glu Lys Phe Asp Cys His Tyr Cys Arg Asp Pro Leu Gln Gly 
1               5                   10                  15      


Lys Lys Tyr Val Gln Lys Asp Gly His His Cys Cys Leu Lys Cys Phe 
            20                  25                  30          


Asp Lys Phe Cys Ala Asn Thr Cys Val Glu Cys Arg Lys Pro Ile Gly 
        35                  40                  45              


Ala Asp Ser Lys Glu Val His Tyr Lys Asn Arg Phe Trp His Asp Thr 
    50                  55                  60                  


Cys Phe Arg Cys Ala Lys Cys Leu His Pro Leu Ala Asn Glu 
65                  70                  75              


<210>  5387
<211>  130
<212>  PRT
<213>  Homo Sapiens

<400>  5387

Met Ala Glu Lys Phe Asp Cys His Tyr Cys Arg Asp Pro Leu Gln Gly 
1               5                   10                  15      


Lys Lys Tyr Val Gln Lys Asp Gly His His Cys Cys Leu Lys Cys Phe 
            20                  25                  30          


Asp Lys Phe Cys Ala Asn Thr Cys Val Glu Cys Arg Lys Pro Ile Gly 
        35                  40                  45              


Ala Asp Ser Lys Glu Val His Tyr Lys Asn Arg Phe Trp His Asp Thr 
    50                  55                  60                  


Cys Phe Arg Cys Ala Lys Cys Leu His Pro Leu Ala Asn Glu Thr Phe 
65                  70                  75                  80  


Val Ala Lys Asp Asn Lys Ile Leu Cys Asn Lys Cys Thr Thr Arg Glu 
                85                  90                  95      


Asp Ser Pro Lys Cys Lys Gly Cys Phe Lys Ala Ile Val Ala Gly Asp 
            100                 105                 110         


Gln Asn Val Glu Tyr Lys Gly Thr Val Trp His Lys Asp Cys Phe Thr 
        115                 120                 125             


Cys Ser 
    130 


<210>  5388
<211>  138
<212>  PRT
<213>  Homo Sapiens

<400>  5388

Met Ala Glu Lys Phe Asp Cys His Tyr Cys Arg Asp Pro Leu Gln Gly 
1               5                   10                  15      


Lys Lys Tyr Val Gln Lys Asp Gly His His Cys Cys Leu Lys Cys Phe 
            20                  25                  30          


Asp Lys Phe Cys Ala Asn Thr Cys Val Glu Cys Arg Lys Pro Ile Gly 
        35                  40                  45              


Ala Asp Ser Lys Glu Val His Tyr Lys Asn Arg Phe Trp His Asp Thr 
    50                  55                  60                  


Cys Phe Arg Cys Ala Lys Cys Leu His Pro Leu Ala Asn Glu Thr Phe 
65                  70                  75                  80  


Val Ala Lys Asp Asn Lys Ile Leu Cys Asn Lys Cys Thr Thr Arg Glu 
                85                  90                  95      


Asp Ser Pro Lys Cys Lys Gly Cys Phe Lys Ala Ile Val Ala Gly Asp 
            100                 105                 110         


Gln Asn Val Glu Tyr Lys Gly Thr Val Trp His Lys Asp Cys Phe Thr 
        115                 120                 125             


Cys Ser Asn Cys Lys Gln Val Ile Gly Thr 
    130                 135             


<210>  5389
<211>  141
<212>  PRT
<213>  Homo Sapiens

<400>  5389

Met Ala Glu Lys Phe Asp Cys His Tyr Cys Arg Asp Pro Leu Gln Gly 
1               5                   10                  15      


Lys Lys Tyr Val Gln Lys Asp Gly His His Cys Cys Leu Lys Cys Phe 
            20                  25                  30          


Asp Lys Phe Cys Ala Asn Thr Cys Val Glu Cys Arg Lys Pro Ile Gly 
        35                  40                  45              


Ala Asp Ser Lys Glu Val His Tyr Lys Asn Arg Phe Trp His Asp Thr 
    50                  55                  60                  


Cys Phe Arg Cys Ala Lys Cys Leu His Pro Leu Ala Asn Glu Thr Phe 
65                  70                  75                  80  


Val Ala Lys Asp Asn Lys Ile Leu Cys Asn Lys Cys Thr Thr Arg Glu 
                85                  90                  95      


Asp Ser Pro Lys Cys Lys Gly Cys Phe Lys Ala Ile Val Ala Gly Asp 
            100                 105                 110         


Gln Asn Val Glu Tyr Lys Gly Thr Val Trp His Lys Asp Cys Phe Thr 
        115                 120                 125             


Cys Ser Asn Cys Lys Gln Val Ile Gly Thr Gly Ser Phe 
    130                 135                 140     


<210>  5390
<211>  147
<212>  PRT
<213>  Homo Sapiens

<400>  5390

Met Ala Glu Lys Phe Asp Cys His Tyr Cys Arg Asp Pro Leu Gln Gly 
1               5                   10                  15      


Lys Lys Tyr Val Gln Lys Asp Gly His His Cys Cys Leu Lys Cys Phe 
            20                  25                  30          


Asp Lys Phe Cys Ala Asn Thr Cys Val Glu Cys Arg Lys Pro Ile Gly 
        35                  40                  45              


Ala Asp Ser Lys Glu Val His Tyr Lys Asn Arg Phe Trp His Asp Thr 
    50                  55                  60                  


Cys Phe Arg Cys Ala Lys Cys Leu His Pro Leu Ala Asn Glu Thr Phe 
65                  70                  75                  80  


Val Ala Lys Asp Asn Lys Ile Leu Cys Asn Lys Cys Thr Thr Arg Glu 
                85                  90                  95      


Asp Ser Pro Lys Cys Lys Gly Cys Phe Lys Ala Ile Val Ala Gly Asp 
            100                 105                 110         


Gln Asn Val Glu Tyr Lys Gly Thr Val Trp His Lys Asp Cys Phe Thr 
        115                 120                 125             


Cys Ser Asn Cys Lys Gln Val Ile Gly Thr Gly Ser Phe Phe Pro Lys 
    130                 135                 140                 


Gly Glu Asp 
145         


<210>  5391
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  5391

Met Ala Glu Lys Phe Asp Cys His Tyr Cys Arg Asp Pro Leu Gln Gly 
1               5                   10                  15      


Lys Lys Tyr Val Gln Lys Asp Gly His His Cys Cys Leu Lys Cys Phe 
            20                  25                  30          


Asp Lys Phe Cys Ala Asn Thr Cys Val Glu Cys Arg Lys Pro Ile Gly 
        35                  40                  45              


Ala Asp Ser Lys Glu Val His Tyr Lys Asn Arg Phe Trp His Asp Thr 
    50                  55                  60                  


Cys Phe Arg Cys Ala Lys Cys Leu His Pro Leu Ala Asn Glu Thr Phe 
65                  70                  75                  80  


Val Ala Lys Asp Asn Lys Ile Leu Cys Asn Lys Cys Thr Thr Arg Glu 
                85                  90                  95      


Asp Ser Pro Lys Cys Lys Gly Cys Phe Lys Ala Ile Val Ala Gly Asp 
            100                 105                 110         


Gln Asn Val Glu Tyr Lys Gly Thr Val Trp His Lys Asp Cys Phe Thr 
        115                 120                 125             


Cys Ser Asn Cys Lys Gln Val Ile Gly Thr Gly Ser Phe Phe Pro Lys 
    130                 135                 140                 


Gly Glu Asp Phe Tyr Cys Val Thr 
145                 150         


<210>  5392
<211>  155
<212>  PRT
<213>  Homo Sapiens

<400>  5392

Met Ala Glu Lys Phe Asp Cys His Tyr Cys Arg Asp Pro Leu Gln Gly 
1               5                   10                  15      


Lys Lys Tyr Val Gln Lys Asp Gly His His Cys Cys Leu Lys Cys Phe 
            20                  25                  30          


Asp Lys Phe Cys Ala Asn Thr Cys Val Glu Cys Arg Lys Pro Ile Gly 
        35                  40                  45              


Ala Asp Ser Lys Glu Val His Tyr Lys Asn Arg Phe Trp His Asp Thr 
    50                  55                  60                  


Cys Phe Arg Cys Ala Lys Cys Leu His Pro Leu Ala Asn Glu Thr Phe 
65                  70                  75                  80  


Val Ala Lys Asp Asn Lys Ile Leu Cys Asn Lys Cys Thr Thr Arg Glu 
                85                  90                  95      


Asp Ser Pro Lys Cys Lys Gly Cys Phe Lys Ala Ile Val Ala Gly Asp 
            100                 105                 110         


Gln Asn Val Glu Tyr Lys Gly Thr Val Trp His Lys Asp Cys Phe Thr 
        115                 120                 125             


Cys Ser Asn Cys Lys Gln Val Ile Gly Thr Gly Ser Phe Phe Pro Lys 
    130                 135                 140                 


Gly Glu Asp Phe Tyr Cys Val Thr Cys His Glu 
145                 150                 155 


<210>  5393
<211>  175
<212>  PRT
<213>  Homo Sapiens

<400>  5393

Met Ala Glu Lys Phe Asp Cys His Tyr Cys Arg Asp Pro Leu Gln Gly 
1               5                   10                  15      


Lys Lys Tyr Val Gln Lys Asp Gly His His Cys Cys Leu Lys Cys Phe 
            20                  25                  30          


Asp Lys Phe Cys Ala Asn Thr Cys Val Glu Cys Arg Lys Pro Ile Gly 
        35                  40                  45              


Ala Asp Ser Lys Glu Val His Tyr Lys Asn Arg Phe Trp His Asp Thr 
    50                  55                  60                  


Cys Phe Arg Cys Ala Lys Cys Leu His Pro Leu Ala Asn Glu Thr Phe 
65                  70                  75                  80  


Val Ala Lys Asp Asn Lys Ile Leu Cys Asn Lys Cys Thr Thr Arg Glu 
                85                  90                  95      


Asp Ser Pro Lys Cys Lys Gly Cys Phe Lys Ala Ile Val Ala Gly Asp 
            100                 105                 110         


Gln Asn Val Glu Tyr Lys Gly Thr Val Trp His Lys Asp Cys Phe Thr 
        115                 120                 125             


Cys Ser Asn Cys Lys Gln Val Ile Gly Thr Gly Ser Phe Phe Pro Lys 
    130                 135                 140                 


Gly Glu Asp Phe Tyr Cys Val Thr Cys His Glu Thr Lys Phe Ala Lys 
145                 150                 155                 160 


His Cys Val Lys Cys Asn Lys Ala Ile Thr Ser Gly Gly Ile Thr 
                165                 170                 175 


<210>  5394
<211>  204
<212>  PRT
<213>  Homo Sapiens

<400>  5394

Met Ala Glu Lys Phe Asp Cys His Tyr Cys Arg Asp Pro Leu Gln Gly 
1               5                   10                  15      


Lys Lys Tyr Val Gln Lys Asp Gly His His Cys Cys Leu Lys Cys Phe 
            20                  25                  30          


Asp Lys Phe Cys Ala Asn Thr Cys Val Glu Cys Arg Lys Pro Ile Gly 
        35                  40                  45              


Ala Asp Ser Lys Glu Val His Tyr Lys Asn Arg Phe Trp His Asp Thr 
    50                  55                  60                  


Cys Phe Arg Cys Ala Lys Cys Leu His Pro Leu Ala Asn Glu Thr Phe 
65                  70                  75                  80  


Val Ala Lys Asp Asn Lys Ile Leu Cys Asn Lys Cys Thr Thr Arg Glu 
                85                  90                  95      


Asp Ser Pro Lys Cys Lys Gly Cys Phe Lys Ala Ile Val Ala Gly Asp 
            100                 105                 110         


Gln Asn Val Glu Tyr Lys Gly Thr Val Trp His Lys Asp Cys Phe Thr 
        115                 120                 125             


Cys Ser Asn Cys Lys Gln Val Ile Gly Thr Gly Ser Phe Phe Pro Lys 
    130                 135                 140                 


Gly Glu Asp Phe Tyr Cys Val Thr Cys His Glu Thr Lys Phe Ala Lys 
145                 150                 155                 160 


His Cys Val Lys Cys Asn Lys Ala Ile Thr Ser Gly Gly Ile Thr Tyr 
                165                 170                 175     


Gln Asp Gln Pro Trp His Ala Asp Cys Phe Val Cys Val Thr Cys Ser 
            180                 185                 190         


Lys Lys Leu Ala Gly Gln Arg Phe Thr Ala Val Glu 
        195                 200                 


<210>  5395
<211>  205
<212>  PRT
<213>  Homo Sapiens

<400>  5395

Met Ala Glu Lys Phe Asp Cys His Tyr Cys Arg Asp Pro Leu Gln Gly 
1               5                   10                  15      


Lys Lys Tyr Val Gln Lys Asp Gly His His Cys Cys Leu Lys Cys Phe 
            20                  25                  30          


Asp Lys Phe Cys Ala Asn Thr Cys Val Glu Cys Arg Lys Pro Ile Gly 
        35                  40                  45              


Ala Asp Ser Lys Glu Val His Tyr Lys Asn Arg Phe Trp His Asp Thr 
    50                  55                  60                  


Cys Phe Arg Cys Ala Lys Cys Leu His Pro Leu Ala Asn Glu Thr Phe 
65                  70                  75                  80  


Val Ala Lys Asp Asn Lys Ile Leu Cys Asn Lys Cys Thr Thr Arg Glu 
                85                  90                  95      


Asp Ser Pro Lys Cys Lys Gly Cys Phe Lys Ala Ile Val Ala Gly Asp 
            100                 105                 110         


Gln Asn Val Glu Tyr Lys Gly Thr Val Trp His Lys Asp Cys Phe Thr 
        115                 120                 125             


Cys Ser Asn Cys Lys Gln Val Ile Gly Thr Gly Ser Phe Phe Pro Lys 
    130                 135                 140                 


Gly Glu Asp Phe Tyr Cys Val Thr Cys His Glu Thr Lys Phe Ala Lys 
145                 150                 155                 160 


His Cys Val Lys Cys Asn Lys Ala Ile Thr Ser Gly Gly Ile Thr Tyr 
                165                 170                 175     


Gln Asp Gln Pro Trp His Ala Asp Cys Phe Val Cys Val Thr Cys Ser 
            180                 185                 190         


Lys Lys Leu Ala Gly Gln Arg Phe Thr Ala Val Glu Asp 
        195                 200                 205 


<210>  5396
<211>  207
<212>  PRT
<213>  Homo Sapiens

<400>  5396

Met Ala Glu Lys Phe Asp Cys His Tyr Cys Arg Asp Pro Leu Gln Gly 
1               5                   10                  15      


Lys Lys Tyr Val Gln Lys Asp Gly His His Cys Cys Leu Lys Cys Phe 
            20                  25                  30          


Asp Lys Phe Cys Ala Asn Thr Cys Val Glu Cys Arg Lys Pro Ile Gly 
        35                  40                  45              


Ala Asp Ser Lys Glu Val His Tyr Lys Asn Arg Phe Trp His Asp Thr 
    50                  55                  60                  


Cys Phe Arg Cys Ala Lys Cys Leu His Pro Leu Ala Asn Glu Thr Phe 
65                  70                  75                  80  


Val Ala Lys Asp Asn Lys Ile Leu Cys Asn Lys Cys Thr Thr Arg Glu 
                85                  90                  95      


Asp Ser Pro Lys Cys Lys Gly Cys Phe Lys Ala Ile Val Ala Gly Asp 
            100                 105                 110         


Gln Asn Val Glu Tyr Lys Gly Thr Val Trp His Lys Asp Cys Phe Thr 
        115                 120                 125             


Cys Ser Asn Cys Lys Gln Val Ile Gly Thr Gly Ser Phe Phe Pro Lys 
    130                 135                 140                 


Gly Glu Asp Phe Tyr Cys Val Thr Cys His Glu Thr Lys Phe Ala Lys 
145                 150                 155                 160 


His Cys Val Lys Cys Asn Lys Ala Ile Thr Ser Gly Gly Ile Thr Tyr 
                165                 170                 175     


Gln Asp Gln Pro Trp His Ala Asp Cys Phe Val Cys Val Thr Cys Ser 
            180                 185                 190         


Lys Lys Leu Ala Gly Gln Arg Phe Thr Ala Val Glu Asp Gln Tyr 
        195                 200                 205         


<210>  5397
<211>  207
<212>  PRT
<213>  Homo Sapiens

<400>  5397

Met Ala Glu Lys Phe Asp Cys His Tyr Cys Arg Asp Pro Leu Gln Gly 
1               5                   10                  15      


Lys Lys Tyr Val Gln Lys Asp Gly His His Cys Cys Leu Lys Cys Phe 
            20                  25                  30          


Asp Lys Phe Cys Ala Asn Thr Cys Val Glu Cys Arg Lys Pro Ile Gly 
        35                  40                  45              


Ala Asp Ser Lys Glu Val His Tyr Lys Asn Arg Phe Trp His Asp Thr 
    50                  55                  60                  


Cys Phe Arg Cys Ala Lys Cys Leu His Pro Leu Ala Asn Glu Thr Phe 
65                  70                  75                  80  


Val Ala Lys Asp Asn Lys Ile Leu Cys Asn Lys Cys Thr Thr Arg Glu 
                85                  90                  95      


Asp Ser Pro Lys Cys Lys Gly Cys Phe Lys Ala Ile Val Ala Gly Asp 
            100                 105                 110         


Gln Asn Val Glu Tyr Lys Gly Thr Val Trp His Lys Asp Cys Phe Thr 
        115                 120                 125             


Cys Ser Asn Cys Lys Gln Val Ile Gly Thr Gly Ser Phe Phe Pro Lys 
    130                 135                 140                 


Gly Glu Asp Phe Tyr Cys Val Thr Cys His Glu Thr Lys Phe Ala Lys 
145                 150                 155                 160 


His Cys Val Lys Cys Asn Lys Ala Ile Thr Ser Gly Gly Ile Thr Tyr 
                165                 170                 175     


Gln Asp Gln Pro Trp His Ala Asp Cys Phe Val Cys Val Thr Cys Ser 
            180                 185                 190         


Lys Lys Leu Ala Gly Gln Arg Phe Thr Ala Val Glu Asp Gln Tyr 
        195                 200                 205         


<210>  5398
<211>  280
<212>  PRT
<213>  Homo Sapiens

<400>  5398

Met Ala Glu Lys Phe Asp Cys His Tyr Cys Arg Asp Pro Leu Gln Gly 
1               5                   10                  15      


Lys Lys Tyr Val Gln Lys Asp Gly His His Cys Cys Leu Lys Cys Phe 
            20                  25                  30          


Asp Lys Phe Cys Ala Asn Thr Cys Val Glu Cys Arg Lys Pro Ile Gly 
        35                  40                  45              


Ala Asp Ser Lys Glu Val His Tyr Lys Asn Arg Phe Trp His Asp Thr 
    50                  55                  60                  


Cys Phe Arg Cys Ala Lys Cys Leu His Pro Leu Ala Asn Glu Thr Phe 
65                  70                  75                  80  


Val Ala Lys Asp Asn Lys Ile Leu Cys Asn Lys Cys Thr Thr Arg Glu 
                85                  90                  95      


Asp Ser Pro Lys Cys Lys Gly Cys Phe Lys Ala Ile Val Ala Gly Asp 
            100                 105                 110         


Gln Asn Val Glu Tyr Lys Gly Thr Val Trp His Lys Asp Cys Phe Thr 
        115                 120                 125             


Cys Ser Asn Cys Lys Gln Val Ile Gly Thr Gly Ser Phe Phe Pro Lys 
    130                 135                 140                 


Gly Glu Asp Phe Tyr Cys Val Thr Cys His Glu Thr Lys Phe Ala Lys 
145                 150                 155                 160 


His Cys Val Lys Cys Asn Lys Ala Ile Thr Ser Gly Gly Ile Thr Tyr 
                165                 170                 175     


Gln Asp Gln Pro Trp His Ala Asp Cys Phe Val Cys Val Thr Cys Ser 
            180                 185                 190         


Lys Lys Leu Ala Gly Gln Arg Phe Thr Ala Val Glu Asp Gln Tyr Tyr 
        195                 200                 205             


Cys Val Asp Cys Tyr Lys Asn Phe Val Ala Lys Lys Cys Ala Gly Cys 
    210                 215                 220                 


Lys Asn Pro Ile Thr Gly Phe Gly Lys Gly Ser Ser Val Val Ala Tyr 
225                 230                 235                 240 


Glu Gly Gln Ser Trp His Asp Tyr Cys Phe His Cys Lys Lys Cys Ser 
                245                 250                 255     


Val Asn Leu Ala Asn Lys Arg Phe Val Phe His Gln Glu Gln Val Tyr 
            260                 265                 270         


Cys Pro Asp Cys Ala Lys Lys Leu 
        275                 280 


<210>  5399
<211>  280
<212>  PRT
<213>  Homo Sapiens

<400>  5399

Met Ala Glu Lys Phe Asp Cys His Tyr Cys Arg Asp Pro Leu Gln Gly 
1               5                   10                  15      


Lys Lys Tyr Val Gln Lys Asp Gly His His Cys Cys Leu Lys Cys Phe 
            20                  25                  30          


Asp Lys Phe Cys Ala Asn Thr Cys Val Glu Cys Arg Lys Pro Ile Gly 
        35                  40                  45              


Ala Asp Ser Lys Glu Val His Tyr Lys Asn Arg Phe Trp His Asp Thr 
    50                  55                  60                  


Cys Phe Arg Cys Ala Lys Cys Leu His Pro Leu Ala Asn Glu Thr Phe 
65                  70                  75                  80  


Val Ala Lys Asp Asn Lys Ile Leu Cys Asn Lys Cys Thr Thr Arg Glu 
                85                  90                  95      


Asp Ser Pro Lys Cys Lys Gly Cys Phe Lys Ala Ile Val Ala Gly Asp 
            100                 105                 110         


Gln Asn Val Glu Tyr Lys Gly Thr Val Trp His Lys Asp Cys Phe Thr 
        115                 120                 125             


Cys Ser Asn Cys Lys Gln Val Ile Gly Thr Gly Ser Phe Phe Pro Lys 
    130                 135                 140                 


Gly Glu Asp Phe Tyr Cys Val Thr Cys His Glu Thr Lys Phe Ala Lys 
145                 150                 155                 160 


His Cys Val Lys Cys Asn Lys Ala Ile Thr Ser Gly Gly Ile Thr Tyr 
                165                 170                 175     


Gln Asp Gln Pro Trp His Ala Asp Cys Phe Val Cys Val Thr Cys Ser 
            180                 185                 190         


Lys Lys Leu Ala Gly Gln Arg Phe Thr Ala Val Glu Asp Gln Tyr Tyr 
        195                 200                 205             


Cys Val Asp Cys Tyr Lys Asn Phe Val Ala Lys Lys Cys Ala Gly Cys 
    210                 215                 220                 


Lys Asn Pro Ile Thr Gly Phe Gly Lys Gly Ser Ser Val Val Ala Tyr 
225                 230                 235                 240 


Glu Gly Gln Ser Trp His Asp Tyr Cys Phe His Cys Lys Lys Cys Ser 
                245                 250                 255     


Val Asn Leu Ala Asn Lys Arg Phe Val Phe His Gln Glu Gln Val Tyr 
            260                 265                 270         


Cys Pro Asp Cys Ala Lys Lys Leu 
        275                 280 


<210>  5400
<211>  257
<212>  PRT
<213>  Homo Sapiens

<400>  5400

Met Ala Glu Lys Phe Asp Cys His Tyr Cys Arg Asp Pro Leu Gln Gly 
1               5                   10                  15      


Lys Lys Tyr Val Gln Lys Asp Gly His His Cys Cys Leu Lys Cys Phe 
            20                  25                  30          


Asp Lys Phe Cys Ala Asn Thr Cys Val Glu Cys Arg Lys Pro Ile Gly 
        35                  40                  45              


Ala Asp Ser Lys Glu Val His Tyr Lys Asn Arg Phe Trp His Asp Thr 
    50                  55                  60                  


Cys Phe Arg Cys Ala Lys Cys Leu His Pro Leu Ala Asn Glu Thr Phe 
65                  70                  75                  80  


Val Ala Lys Asp Asn Lys Ile Leu Cys Asn Lys Cys Thr Thr Arg Glu 
                85                  90                  95      


Asp Ser Pro Lys Cys Lys Gly Cys Phe Lys Ala Ile Val Ala Gly Asp 
            100                 105                 110         


Gln Asn Val Glu Tyr Lys Gly Thr Val Trp His Lys Asp Cys Phe Thr 
        115                 120                 125             


Cys Ser Asn Cys Lys Gln Val Ile Gly Thr Gly Ser Phe Phe Pro Lys 
    130                 135                 140                 


Gly Glu Asp Phe Tyr Cys Val Thr Cys His Glu Thr Lys Phe Ala Lys 
145                 150                 155                 160 


His Cys Val Lys Cys Asn Lys Ala Ile Thr Ser Gly Gly Ile Thr Tyr 
                165                 170                 175     


Gln Asp Gln Pro Trp His Ala Asp Cys Phe Val Cys Val Thr Cys Ser 
            180                 185                 190         


Lys Lys Leu Ala Gly Gln Arg Phe Thr Ala Val Glu Asp Gln Tyr Tyr 
        195                 200                 205             


Cys Val Asp Cys Tyr Lys Asn Phe Val Ala Lys Lys Cys Ala Gly Cys 
    210                 215                 220                 


Lys Asn Pro Ile Thr Gly Phe Gly Lys Gly Ser Ser Val Val Ala Tyr 
225                 230                 235                 240 


Glu Gly Gln Ser Trp His Asp Tyr Cys Phe His Cys Lys Lys Cys Ser 
                245                 250                 255     


Val 
    


<210>  5401
<211>  280
<212>  PRT
<213>  Homo Sapiens

<400>  5401

Met Ala Glu Lys Phe Asp Cys His Tyr Cys Arg Asp Pro Leu Gln Gly 
1               5                   10                  15      


Lys Lys Tyr Val Gln Lys Asp Gly His His Cys Cys Leu Lys Cys Phe 
            20                  25                  30          


Asp Lys Phe Cys Ala Asn Thr Cys Val Glu Cys Arg Lys Pro Ile Gly 
        35                  40                  45              


Ala Asp Ser Lys Glu Val His Tyr Lys Asn Arg Phe Trp His Asp Thr 
    50                  55                  60                  


Cys Phe Arg Cys Ala Lys Cys Leu His Pro Leu Ala Asn Glu Thr Phe 
65                  70                  75                  80  


Val Ala Lys Asp Asn Lys Ile Leu Cys Asn Lys Cys Thr Thr Arg Glu 
                85                  90                  95      


Asp Ser Pro Lys Cys Lys Gly Cys Phe Lys Ala Ile Val Ala Gly Asp 
            100                 105                 110         


Gln Asn Val Glu Tyr Lys Gly Thr Val Trp His Lys Asp Cys Phe Thr 
        115                 120                 125             


Cys Ser Asn Cys Lys Gln Val Ile Gly Thr Gly Ser Phe Phe Pro Lys 
    130                 135                 140                 


Gly Glu Asp Phe Tyr Cys Val Thr Cys His Glu Thr Lys Phe Ala Lys 
145                 150                 155                 160 


His Cys Val Lys Cys Asn Lys Ala Ile Thr Ser Gly Gly Ile Thr Tyr 
                165                 170                 175     


Gln Asp Gln Pro Trp His Ala Asp Cys Phe Val Cys Val Thr Cys Ser 
            180                 185                 190         


Lys Lys Leu Ala Gly Gln Arg Phe Thr Ala Val Glu Asp Gln Tyr Tyr 
        195                 200                 205             


Cys Val Asp Cys Tyr Lys Asn Phe Val Ala Lys Lys Cys Ala Gly Cys 
    210                 215                 220                 


Lys Asn Pro Ile Thr Gly Phe Gly Lys Gly Ser Ser Val Val Ala Tyr 
225                 230                 235                 240 


Glu Gly Gln Ser Trp His Asp Tyr Cys Phe His Cys Lys Lys Cys Ser 
                245                 250                 255     


Val Asn Leu Ala Asn Lys Arg Phe Val Phe His Gln Glu Gln Val Tyr 
            260                 265                 270         


Cys Pro Asp Cys Ala Lys Lys Leu 
        275                 280 


<210>  5402
<211>  280
<212>  PRT
<213>  Homo Sapiens

<400>  5402

Met Ala Glu Lys Phe Asp Cys His Tyr Cys Arg Asp Pro Leu Gln Gly 
1               5                   10                  15      


Lys Lys Tyr Val Gln Lys Asp Gly His His Cys Cys Leu Lys Cys Phe 
            20                  25                  30          


Asp Lys Phe Cys Ala Asn Thr Cys Val Glu Cys Arg Lys Pro Ile Gly 
        35                  40                  45              


Ala Asp Ser Lys Glu Val His Tyr Lys Asn Arg Phe Trp His Asp Thr 
    50                  55                  60                  


Cys Phe Arg Cys Ala Lys Cys Leu His Pro Leu Ala Asn Glu Thr Phe 
65                  70                  75                  80  


Val Ala Lys Asp Asn Lys Ile Leu Cys Asn Lys Cys Thr Thr Arg Glu 
                85                  90                  95      


Asp Ser Pro Lys Cys Lys Gly Cys Phe Lys Ala Ile Val Ala Gly Asp 
            100                 105                 110         


Gln Asn Val Glu Tyr Lys Gly Thr Val Trp His Lys Asp Cys Phe Thr 
        115                 120                 125             


Cys Ser Asn Cys Lys Gln Val Ile Gly Thr Gly Ser Phe Phe Pro Lys 
    130                 135                 140                 


Gly Glu Asp Phe Tyr Cys Val Thr Cys His Glu Thr Lys Phe Ala Lys 
145                 150                 155                 160 


His Cys Val Lys Cys Asn Lys Ala Ile Thr Ser Gly Gly Ile Thr Tyr 
                165                 170                 175     


Gln Asp Gln Pro Trp His Ala Asp Cys Phe Val Cys Val Thr Cys Ser 
            180                 185                 190         


Lys Lys Leu Ala Gly Gln Arg Phe Thr Ala Val Glu Asp Gln Tyr Tyr 
        195                 200                 205             


Cys Val Asp Cys Tyr Lys Asn Phe Val Ala Lys Lys Cys Ala Gly Cys 
    210                 215                 220                 


Lys Asn Pro Ile Thr Gly Phe Gly Lys Gly Ser Ser Val Val Ala Tyr 
225                 230                 235                 240 


Glu Gly Gln Ser Trp His Asp Tyr Cys Phe His Cys Lys Lys Cys Ser 
                245                 250                 255     


Val Asn Leu Ala Asn Lys Arg Phe Val Phe His Gln Glu Gln Val Tyr 
            260                 265                 270         


Cys Pro Asp Cys Ala Lys Lys Leu 
        275                 280 


<210>  5403
<211>  280
<212>  PRT
<213>  Homo Sapiens

<400>  5403

Met Ala Glu Lys Phe Asp Cys His Tyr Cys Arg Asp Pro Leu Gln Gly 
1               5                   10                  15      


Lys Lys Tyr Val Gln Lys Asp Gly His His Cys Cys Leu Lys Cys Phe 
            20                  25                  30          


Asp Lys Phe Cys Ala Asn Thr Cys Val Glu Cys Arg Lys Pro Ile Gly 
        35                  40                  45              


Ala Asp Ser Lys Glu Val His Tyr Lys Asn Arg Phe Trp His Asp Thr 
    50                  55                  60                  


Cys Phe Arg Cys Ala Lys Cys Leu His Pro Leu Ala Asn Glu Thr Phe 
65                  70                  75                  80  


Val Ala Lys Asp Asn Lys Ile Leu Cys Asn Lys Cys Thr Thr Arg Glu 
                85                  90                  95      


Asp Ser Pro Lys Cys Lys Gly Cys Phe Lys Ala Ile Val Ala Gly Asp 
            100                 105                 110         


Gln Asn Val Glu Tyr Lys Gly Thr Val Trp His Lys Asp Cys Phe Thr 
        115                 120                 125             


Cys Ser Asn Cys Lys Gln Val Ile Gly Thr Gly Ser Phe Phe Pro Lys 
    130                 135                 140                 


Gly Glu Asp Phe Tyr Cys Val Thr Cys His Glu Thr Lys Phe Ala Lys 
145                 150                 155                 160 


His Cys Val Lys Cys Asn Lys Ala Ile Thr Ser Gly Gly Ile Thr Tyr 
                165                 170                 175     


Gln Asp Gln Pro Trp His Ala Asp Cys Phe Val Cys Val Thr Cys Ser 
            180                 185                 190         


Lys Lys Leu Ala Gly Gln Arg Phe Thr Ala Val Glu Asp Gln Tyr Tyr 
        195                 200                 205             


Cys Val Asp Cys Tyr Lys Asn Phe Val Ala Lys Lys Cys Ala Gly Cys 
    210                 215                 220                 


Lys Asn Pro Ile Thr Gly Phe Gly Lys Gly Ser Ser Val Val Ala Tyr 
225                 230                 235                 240 


Glu Gly Gln Ser Trp His Asp Tyr Cys Phe His Cys Lys Lys Cys Ser 
                245                 250                 255     


Val Asn Leu Ala Asn Lys Arg Phe Val Phe His Gln Glu Gln Val Tyr 
            260                 265                 270         


Cys Pro Asp Cys Ala Lys Lys Leu 
        275                 280 


<210>  5404
<211>  280
<212>  PRT
<213>  Homo Sapiens

<400>  5404

Met Ala Glu Lys Phe Asp Cys His Tyr Cys Arg Asp Pro Leu Gln Gly 
1               5                   10                  15      


Lys Lys Tyr Val Gln Lys Asp Gly His His Cys Cys Leu Lys Cys Phe 
            20                  25                  30          


Asp Lys Phe Cys Ala Asn Thr Cys Val Glu Cys Arg Lys Pro Ile Gly 
        35                  40                  45              


Ala Asp Ser Lys Glu Val His Tyr Lys Asn Arg Phe Trp His Asp Thr 
    50                  55                  60                  


Cys Phe Arg Cys Ala Lys Cys Leu His Pro Leu Ala Asn Glu Thr Phe 
65                  70                  75                  80  


Val Ala Lys Asp Asn Lys Ile Leu Cys Asn Lys Cys Thr Thr Arg Glu 
                85                  90                  95      


Asp Ser Pro Lys Cys Lys Gly Cys Phe Lys Ala Ile Val Ala Gly Asp 
            100                 105                 110         


Gln Asn Val Glu Tyr Lys Gly Thr Val Trp His Lys Asp Cys Phe Thr 
        115                 120                 125             


Cys Ser Asn Cys Lys Gln Val Ile Gly Thr Gly Ser Phe Phe Pro Lys 
    130                 135                 140                 


Gly Glu Asp Phe Tyr Cys Val Thr Cys His Glu Thr Lys Phe Ala Lys 
145                 150                 155                 160 


His Cys Val Lys Cys Asn Lys Ala Ile Thr Ser Gly Gly Ile Thr Tyr 
                165                 170                 175     


Gln Asp Gln Pro Trp His Ala Asp Cys Phe Val Cys Val Thr Cys Ser 
            180                 185                 190         


Lys Lys Leu Ala Gly Gln Arg Phe Thr Ala Val Glu Asp Gln Tyr Tyr 
        195                 200                 205             


Cys Val Asp Cys Tyr Lys Asn Phe Val Ala Lys Lys Cys Ala Gly Cys 
    210                 215                 220                 


Lys Asn Pro Ile Thr Gly Phe Gly Lys Gly Ser Ser Val Val Ala Tyr 
225                 230                 235                 240 


Glu Gly Gln Ser Trp His Asp Tyr Cys Phe His Cys Lys Lys Cys Ser 
                245                 250                 255     


Val Asn Leu Ala Asn Lys Arg Phe Val Phe His Gln Glu Gln Val Tyr 
            260                 265                 270         


Cys Pro Asp Cys Ala Lys Lys Leu 
        275                 280 


<210>  5405
<211>  280
<212>  PRT
<213>  Homo Sapiens

<400>  5405

Met Ala Glu Lys Phe Asp Cys His Tyr Cys Arg Asp Pro Leu Gln Gly 
1               5                   10                  15      


Lys Lys Tyr Val Gln Lys Asp Gly His His Cys Cys Leu Lys Cys Phe 
            20                  25                  30          


Asp Lys Phe Cys Ala Asn Thr Cys Val Glu Cys Arg Lys Pro Ile Gly 
        35                  40                  45              


Ala Asp Ser Lys Glu Val His Tyr Lys Asn Arg Phe Trp His Asp Thr 
    50                  55                  60                  


Cys Phe Arg Cys Ala Lys Cys Leu His Pro Leu Ala Asn Glu Thr Phe 
65                  70                  75                  80  


Val Ala Lys Asp Asn Lys Ile Leu Cys Asn Lys Cys Thr Thr Arg Glu 
                85                  90                  95      


Asp Ser Pro Lys Cys Lys Gly Cys Phe Lys Ala Ile Val Ala Gly Asp 
            100                 105                 110         


Gln Asn Val Glu Tyr Lys Gly Thr Val Trp His Lys Asp Cys Phe Thr 
        115                 120                 125             


Cys Ser Asn Cys Lys Gln Val Ile Gly Thr Gly Ser Phe Phe Pro Lys 
    130                 135                 140                 


Gly Glu Asp Phe Tyr Cys Val Thr Cys His Glu Thr Lys Phe Ala Lys 
145                 150                 155                 160 


His Cys Val Lys Cys Asn Lys Ala Ile Thr Ser Gly Gly Ile Thr Tyr 
                165                 170                 175     


Gln Asp Gln Pro Trp His Ala Asp Cys Phe Val Cys Val Thr Cys Ser 
            180                 185                 190         


Lys Lys Leu Ala Gly Gln Arg Phe Thr Ala Val Glu Asp Gln Tyr Tyr 
        195                 200                 205             


Cys Val Asp Cys Tyr Lys Asn Phe Val Ala Lys Lys Cys Ala Gly Cys 
    210                 215                 220                 


Lys Asn Pro Ile Thr Gly Phe Gly Lys Gly Ser Ser Val Val Ala Tyr 
225                 230                 235                 240 


Glu Gly Gln Ser Trp His Asp Tyr Cys Phe His Cys Lys Lys Cys Ser 
                245                 250                 255     


Val Asn Leu Ala Asn Lys Arg Phe Val Phe His Gln Glu Gln Val Tyr 
            260                 265                 270         


Cys Pro Asp Cys Ala Lys Lys Leu 
        275                 280 


<210>  5406
<211>  323
<212>  PRT
<213>  Homo Sapiens

<400>  5406

Met Ala Glu Lys Phe Asp Cys His Tyr Cys Arg Asp Pro Leu Gln Gly 
1               5                   10                  15      


Lys Lys Tyr Val Gln Lys Asp Gly His His Cys Cys Leu Lys Cys Phe 
            20                  25                  30          


Asp Lys Phe Cys Ala Asn Thr Cys Val Glu Cys Arg Lys Pro Ile Gly 
        35                  40                  45              


Ala Asp Ser Lys Glu Val His Tyr Lys Asn Arg Phe Trp His Asp Thr 
    50                  55                  60                  


Cys Phe Arg Cys Ala Lys Cys Leu His Pro Leu Ala Asn Glu Thr Phe 
65                  70                  75                  80  


Val Ala Lys Asp Asn Lys Ile Leu Cys Asn Lys Cys Thr Thr Arg Glu 
                85                  90                  95      


Asp Ser Pro Lys Cys Lys Gly Cys Phe Lys Ala Ile Val Ala Gly Asp 
            100                 105                 110         


Gln Asn Val Glu Tyr Lys Gly Thr Val Trp His Lys Asp Cys Phe Thr 
        115                 120                 125             


Cys Ser Asn Cys Lys Gln Val Ile Gly Thr Gly Ser Phe Phe Pro Lys 
    130                 135                 140                 


Gly Glu Asp Phe Tyr Cys Val Thr Cys His Glu Thr Lys Phe Ala Lys 
145                 150                 155                 160 


His Cys Val Lys Cys Asn Lys Ala Ile Thr Ser Gly Gly Ile Thr Tyr 
                165                 170                 175     


Gln Asp Gln Pro Trp His Ala Asp Cys Phe Val Cys Val Thr Cys Ser 
            180                 185                 190         


Lys Lys Leu Ala Gly Gln Arg Phe Thr Ala Val Glu Asp Gln Tyr Tyr 
        195                 200                 205             


Cys Val Asp Cys Tyr Lys Asn Phe Val Ala Lys Lys Cys Ala Gly Cys 
    210                 215                 220                 


Lys Asn Pro Ile Thr Gly Lys Arg Thr Val Ser Arg Val Ser His Pro 
225                 230                 235                 240 


Val Ser Lys Ala Arg Lys Pro Pro Val Cys His Gly Lys Arg Leu Pro 
                245                 250                 255     


Leu Thr Leu Phe Pro Ser Ala Asn Leu Arg Gly Arg His Pro Gly Gly 
            260                 265                 270         


Glu Arg Thr Cys Pro Ser Trp Val Val Val Leu Tyr Arg Lys Asn Arg 
        275                 280                 285             


Ser Leu Ala Ala Pro Arg Gly Pro Gly Leu Val Lys Ala Pro Val Trp 
    290                 295                 300                 


Trp Pro Met Lys Asp Asn Pro Gly Thr Thr Thr Ala Ser Thr Ala Lys 
305                 310                 315                 320 


Asn Ala Pro 
            


<210>  5407
<211>  323
<212>  PRT
<213>  Homo Sapiens

<400>  5407

Met Ala Glu Lys Phe Asp Cys His Tyr Cys Arg Asp Pro Leu Gln Gly 
1               5                   10                  15      


Lys Lys Tyr Val Gln Lys Asp Gly His His Cys Cys Leu Lys Cys Phe 
            20                  25                  30          


Asp Lys Phe Cys Ala Asn Thr Cys Val Glu Cys Arg Lys Pro Ile Gly 
        35                  40                  45              


Ala Asp Ser Lys Glu Val His Tyr Lys Asn Arg Phe Trp His Asp Thr 
    50                  55                  60                  


Cys Phe Arg Cys Ala Lys Cys Leu His Pro Leu Ala Asn Glu Thr Phe 
65                  70                  75                  80  


Val Ala Lys Asp Asn Lys Ile Leu Cys Asn Lys Cys Thr Thr Arg Glu 
                85                  90                  95      


Asp Ser Pro Lys Cys Lys Gly Cys Phe Lys Ala Ile Val Ala Gly Asp 
            100                 105                 110         


Gln Asn Val Glu Tyr Lys Gly Thr Val Trp His Lys Asp Cys Phe Thr 
        115                 120                 125             


Cys Ser Asn Cys Lys Gln Val Ile Gly Thr Gly Ser Phe Phe Pro Lys 
    130                 135                 140                 


Gly Glu Asp Phe Tyr Cys Val Thr Cys His Glu Thr Lys Phe Ala Lys 
145                 150                 155                 160 


His Cys Val Lys Cys Asn Lys Ala Ile Thr Ser Gly Gly Ile Thr Tyr 
                165                 170                 175     


Gln Asp Gln Pro Trp His Ala Asp Cys Phe Val Cys Val Thr Cys Ser 
            180                 185                 190         


Lys Lys Leu Ala Gly Gln Arg Phe Thr Ala Val Glu Asp Gln Tyr Tyr 
        195                 200                 205             


Cys Val Asp Cys Tyr Lys Asn Phe Val Ala Lys Lys Cys Ala Gly Cys 
    210                 215                 220                 


Lys Asn Pro Ile Thr Gly Lys Arg Thr Val Ser Arg Val Ser His Pro 
225                 230                 235                 240 


Val Ser Lys Ala Arg Lys Pro Pro Val Cys His Gly Lys Arg Leu Pro 
                245                 250                 255     


Leu Thr Leu Phe Pro Ser Ala Asn Leu Arg Gly Arg His Pro Gly Gly 
            260                 265                 270         


Glu Arg Thr Cys Pro Ser Trp Val Val Val Leu Tyr Arg Lys Asn Arg 
        275                 280                 285             


Ser Leu Ala Ala Pro Arg Gly Pro Gly Leu Val Lys Ala Pro Val Trp 
    290                 295                 300                 


Trp Pro Met Lys Asp Asn Pro Gly Thr Thr Thr Ala Ser Thr Ala Lys 
305                 310                 315                 320 


Asn Ala Pro 
            


<210>  5408
<211>  194
<212>  PRT
<213>  Homo Sapiens

<400>  5408

Met Ala Glu Lys Phe Asp Cys His Tyr Cys Arg Asp Pro Leu Gln Gly 
1               5                   10                  15      


Lys Lys Tyr Val Gln Lys Asp Gly His His Cys Cys Leu Lys Cys Phe 
            20                  25                  30          


Asp Lys Phe Cys Ala Asn Thr Cys Val Glu Cys Arg Lys Pro Ile Gly 
        35                  40                  45              


Ala Asp Ser Lys Glu Val His Tyr Lys Asn Arg Phe Trp His Asp Thr 
    50                  55                  60                  


Cys Phe Arg Cys Ala Lys Cys Leu His Pro Leu Ala Asn Glu Thr Phe 
65                  70                  75                  80  


Val Ala Lys Asp Asn Lys Ile Leu Cys Asn Lys Cys Thr Thr Arg Glu 
                85                  90                  95      


Asp Ser Pro Lys Cys Lys Gly Cys Phe Lys Ala Ile Val Ala Gly Asp 
            100                 105                 110         


Gln Asn Val Glu Tyr Lys Gly Thr Val Trp His Lys Asp Cys Phe Thr 
        115                 120                 125             


Cys Ser Asn Cys Lys Gln Val Ile Gly Thr Gly Ser Phe Phe Pro Lys 
    130                 135                 140                 


Gly Glu Asp Phe Tyr Cys Val Thr Cys His Glu Thr Lys Phe Ala Lys 
145                 150                 155                 160 


His Cys Val Lys Cys Asn Lys Gly Leu Val Lys Ala Pro Val Trp Trp 
                165                 170                 175     


Pro Met Lys Asp Asn Pro Gly Thr Thr Thr Ala Ser Thr Ala Lys Asn 
            180                 185                 190         


Ala Pro 
        


<210>  5409
<211>  296
<212>  PRT
<213>  Homo Sapiens

<400>  5409

Met Ala Ser His Arg His Ser Gly Pro Ser Ser Tyr Lys Val Gly Thr 
1               5                   10                  15      


Met Ala Glu Lys Phe Asp Cys His Tyr Cys Arg Asp Pro Leu Gln Gly 
            20                  25                  30          


Lys Lys Tyr Val Gln Lys Asp Gly His His Cys Cys Leu Lys Cys Phe 
        35                  40                  45              


Asp Lys Phe Cys Ala Asn Thr Cys Val Glu Cys Arg Lys Pro Ile Gly 
    50                  55                  60                  


Ala Asp Ser Lys Glu Val His Tyr Lys Asn Arg Phe Trp His Asp Thr 
65                  70                  75                  80  


Cys Phe Arg Cys Ala Lys Cys Leu His Pro Leu Ala Asn Glu Thr Phe 
                85                  90                  95      


Val Ala Lys Asp Asn Lys Ile Leu Cys Asn Lys Cys Thr Thr Arg Glu 
            100                 105                 110         


Asp Ser Pro Lys Cys Lys Gly Cys Phe Lys Ala Ile Val Ala Gly Asp 
        115                 120                 125             


Gln Asn Val Glu Tyr Lys Gly Thr Val Trp His Lys Asp Cys Phe Thr 
    130                 135                 140                 


Cys Ser Asn Cys Lys Gln Val Ile Gly Thr Gly Ser Phe Phe Pro Lys 
145                 150                 155                 160 


Gly Glu Asp Phe Tyr Cys Val Thr Cys His Glu Thr Lys Phe Ala Lys 
                165                 170                 175     


His Cys Val Lys Cys Asn Lys Ala Ile Thr Ser Gly Gly Ile Thr Tyr 
            180                 185                 190         


Gln Asp Gln Pro Trp His Ala Asp Cys Phe Val Cys Val Thr Cys Ser 
        195                 200                 205             


Lys Lys Leu Ala Gly Gln Arg Phe Thr Ala Val Glu Asp Gln Tyr Tyr 
    210                 215                 220                 


Cys Val Asp Cys Tyr Lys Asn Phe Val Ala Lys Lys Cys Ala Gly Cys 
225                 230                 235                 240 


Lys Asn Pro Ile Thr Gly Phe Gly Lys Gly Ser Ser Val Val Ala Tyr 
                245                 250                 255     


Glu Gly Gln Ser Trp His Asp Tyr Cys Phe His Cys Lys Lys Cys Ser 
            260                 265                 270         


Val Asn Leu Ala Asn Lys Arg Phe Val Phe His Gln Glu Gln Val Tyr 
        275                 280                 285             


Cys Pro Asp Cys Ala Lys Lys Leu 
    290                 295     


<210>  5410
<211>  210
<212>  PRT
<213>  Homo Sapiens

<400>  5410

Met Ala Ser His Arg His Ser Gly Pro Ser Ser Tyr Lys Val Gly Thr 
1               5                   10                  15      


Met Ala Glu Lys Phe Asp Cys His Tyr Cys Arg Asp Pro Leu Gln Gly 
            20                  25                  30          


Lys Lys Tyr Val Gln Lys Asp Gly His His Cys Cys Leu Lys Cys Phe 
        35                  40                  45              


Asp Lys Phe Cys Ala Asn Thr Cys Val Glu Cys Arg Lys Pro Ile Gly 
    50                  55                  60                  


Ala Asp Ser Lys Glu Val His Tyr Lys Asn Arg Phe Trp His Asp Thr 
65                  70                  75                  80  


Cys Phe Arg Cys Ala Lys Cys Leu His Pro Leu Ala Asn Glu Thr Phe 
                85                  90                  95      


Val Ala Lys Asp Asn Lys Ile Leu Cys Asn Lys Cys Thr Thr Arg Glu 
            100                 105                 110         


Asp Ser Pro Lys Cys Lys Gly Cys Phe Lys Ala Ile Val Ala Gly Asp 
        115                 120                 125             


Gln Asn Val Glu Tyr Lys Gly Thr Val Trp His Lys Asp Cys Phe Thr 
    130                 135                 140                 


Cys Ser Asn Cys Lys Gln Val Ile Gly Thr Gly Ser Phe Phe Pro Lys 
145                 150                 155                 160 


Gly Glu Asp Phe Tyr Cys Val Thr Cys His Glu Thr Lys Phe Ala Lys 
                165                 170                 175     


His Cys Val Lys Cys Asn Lys Gly Leu Val Lys Ala Pro Val Trp Trp 
            180                 185                 190         


Pro Met Lys Asp Asn Pro Gly Thr Thr Thr Ala Ser Thr Ala Lys Asn 
        195                 200                 205             


Ala Pro 
    210 


<210>  5411
<211>  309
<212>  PRT
<213>  Homo Sapiens

<400>  5411

Met Thr Phe Tyr Val Ala Ser Leu Ala Leu Glu Leu Ile Trp Met Leu 
1               5                   10                  15      


Ser Ser Pro Ala Gly Pro Ser Ser Tyr Lys Val Gly Thr Met Ala Glu 
            20                  25                  30          


Lys Phe Asp Cys His Tyr Cys Arg Asp Pro Leu Gln Gly Lys Lys Tyr 
        35                  40                  45              


Val Gln Lys Asp Gly His His Cys Cys Leu Lys Cys Phe Asp Lys Phe 
    50                  55                  60                  


Cys Ala Asn Thr Cys Val Glu Cys Arg Lys Pro Ile Gly Ala Asp Ser 
65                  70                  75                  80  


Lys Glu Val His Tyr Lys Asn Arg Phe Trp His Asp Thr Cys Phe Arg 
                85                  90                  95      


Cys Ala Lys Cys Leu His Pro Leu Ala Asn Glu Thr Phe Val Ala Lys 
            100                 105                 110         


Asp Asn Lys Ile Leu Cys Asn Lys Cys Thr Thr Arg Glu Asp Ser Pro 
        115                 120                 125             


Lys Cys Lys Gly Cys Phe Lys Ala Ile Val Ala Gly Asp Gln Asn Val 
    130                 135                 140                 


Glu Tyr Lys Gly Thr Val Trp His Lys Asp Cys Phe Thr Cys Ser Asn 
145                 150                 155                 160 


Cys Lys Gln Val Ile Gly Thr Gly Ser Phe Phe Pro Lys Gly Glu Asp 
                165                 170                 175     


Phe Tyr Cys Val Thr Cys His Glu Thr Lys Phe Ala Lys His Cys Val 
            180                 185                 190         


Lys Cys Asn Lys Ala Ile Thr Ser Gly Gly Ile Thr Tyr Gln Asp Gln 
        195                 200                 205             


Pro Trp His Ala Asp Cys Phe Val Cys Val Thr Cys Ser Lys Lys Leu 
    210                 215                 220                 


Ala Gly Gln Arg Phe Thr Ala Val Glu Asp Gln Tyr Tyr Cys Val Asp 
225                 230                 235                 240 


Cys Tyr Lys Asn Phe Val Ala Lys Lys Cys Ala Gly Cys Lys Asn Pro 
                245                 250                 255     


Ile Thr Gly Phe Gly Lys Gly Ser Ser Val Val Ala Tyr Glu Gly Gln 
            260                 265                 270         


Ser Trp His Asp Tyr Cys Phe His Cys Lys Lys Cys Ser Val Asn Leu 
        275                 280                 285             


Ala Asn Lys Arg Phe Val Phe His Gln Glu Gln Val Tyr Cys Pro Asp 
    290                 295                 300                 


Cys Ala Lys Lys Leu 
305                 


<210>  5412
<211>  635
<212>  PRT
<213>  Homo Sapiens

<400>  5412

Met Ala Met Arg Pro Arg Ser His Pro Pro Val Gly Ala Gly Thr Gly 
1               5                   10                  15      


Gly Gly Pro Ala Cys Val Pro Val Ala Glu Ala Ser Thr Gly Ala Trp 
            20                  25                  30          


Thr Ala Glu Gly Ala Ala Gly Thr Arg Cys Arg Ala Ser Arg Ala Pro 
        35                  40                  45              


Cys Arg Pro Pro Pro Val Pro Ala Pro Ser Gln Leu Pro Ala Ser Ser 
    50                  55                  60                  


Pro Thr Lys Cys Glu Ile Cys Val Lys Asn Thr Ala Ile Leu Ala Ile 
65                  70                  75                  80  


Thr Leu Ile Thr Pro Gln Asp Pro His Leu Asp Pro Val Pro Arg Gly 
                85                  90                  95      


Gln Pro Thr Phe Thr Lys Lys Lys Lys Thr Ile Arg Leu Phe Trp Asn 
            100                 105                 110         


Glu Val Arg Pro Phe Asp Trp Pro Cys Lys Asn Asn Arg Arg Cys Arg 
        115                 120                 125             


Glu Phe Leu Trp Ser Lys Leu Glu Pro Ile Lys Val Asp Thr Ser Arg 
    130                 135                 140                 


Leu Glu His Leu Phe Glu Ser Lys Ser Lys Glu Leu Ser Val Ser Lys 
145                 150                 155                 160 


Lys Thr Ala Ala Asp Gly Lys Arg Gln Glu Ile Ile Val Leu Asp Ser 
                165                 170                 175     


Lys Arg Ser Asn Ala Ile Asn Ile Gly Leu Thr Val Leu Pro Pro Pro 
            180                 185                 190         


Arg Thr Ile Lys Ile Ala Ile Leu Asn Phe Asp Glu Tyr Ala Leu Asn 
        195                 200                 205             


Lys Glu Gly Ile Glu Lys Ile Leu Thr Met Ile Pro Thr Asp Glu Glu 
    210                 215                 220                 


Lys Gln Lys Ile Gln Glu Ala Gln Leu Ala Asn Pro Glu Ile Pro Leu 
225                 230                 235                 240 


Gly Ser Ala Glu Gln Phe Leu Leu Thr Leu Ser Ser Ile Ser Glu Leu 
                245                 250                 255     


Ser Ala Arg Leu His Leu Trp Ala Phe Lys Met Asp Tyr Glu Thr Thr 
            260                 265                 270         


Glu Lys Glu Val Ala Glu Pro Leu Leu Asp Leu Lys Glu Gly Ile Asp 
        275                 280                 285             


Gln Leu Glu Asn Asn Lys Thr Leu Gly Phe Ile Leu Ser Thr Leu Leu 
    290                 295                 300                 


Ala Ile Gly Asn Phe Leu Asn Gly Thr Asn Ala Lys Ala Phe Glu Leu 
305                 310                 315                 320 


Ser Tyr Leu Glu Lys Val Pro Glu Val Lys Asp Thr Val His Lys Gln 
                325                 330                 335     


Ser Leu Leu His His Val Cys Thr Met Val Val Glu Asn Phe Pro Asp 
            340                 345                 350         


Ser Ser Asp Leu Tyr Ser Glu Ile Gly Ala Ile Thr Arg Ser Ala Lys 
        355                 360                 365             


Val Asp Phe Asp Gln Leu Gln Asp Asn Leu Cys Gln Met Glu Arg Arg 
    370                 375                 380                 


Cys Lys Ala Ser Trp Asp His Leu Lys Ala Ile Ala Lys His Glu Met 
385                 390                 395                 400 


Lys Pro Val Leu Lys Gln Arg Met Ser Glu Phe Leu Lys Asp Cys Ala 
                405                 410                 415     


Glu Arg Ile Ile Ile Leu Lys Ile Val His Arg Arg Ile Ile Asn Arg 
            420                 425                 430         


Phe His Ser Phe Leu Leu Phe Met Gly His Pro Pro Tyr Ala Ile Arg 
        435                 440                 445             


Glu Val Asn Ile Asn Lys Phe Cys Arg Ile Ile Ser Glu Phe Ala Leu 
    450                 455                 460                 


Glu Tyr Arg Thr Thr Arg Glu Arg Val Leu Gln Gln Lys Gln Lys Arg 
465                 470                 475                 480 


Ala Asn His Arg Glu Arg Asn Lys Thr Arg Gly Lys Met Ile Thr Asp 
                485                 490                 495     


Ser Gly Lys Phe Ser Gly Ser Ser Pro Ala Pro Pro Ser Gln Pro Gln 
            500                 505                 510         


Gly Leu Ser Tyr Ala Glu Asp Ala Ala Glu His Glu Asn Met Lys Ala 
        515                 520                 525             


Val Leu Lys Thr Ser Ser Pro Ser Val Glu Asp Ala Thr Pro Ala Leu 
    530                 535                 540                 


Gly Val Arg Thr Arg Ser Arg Ala Ser Arg Gly Ser Thr Ser Ser Trp 
545                 550                 555                 560 


Thr Met Gly Thr Asp Asp Ser Pro Asn Val Thr Asp Asp Ala Ala Asp 
                565                 570                 575     


Glu Ile Met Asp Arg Ile Val Lys Ser Ala Thr Gln Val Pro Ser Gln 
            580                 585                 590         


Arg Val Val Pro Arg Glu Arg Lys Arg Ser Arg Ala Asn Arg Lys Ser 
        595                 600                 605             


Leu Arg Arg Thr Leu Lys Ser Gly Leu Thr Pro Glu Glu Ala Arg Ala 
    610                 615                 620                 


Leu Gly Leu Val Gly Thr Ser Glu Leu Gln Leu 
625                 630                 635 


<210>  5413
<211>  1439
<212>  PRT
<213>  Homo Sapiens

<400>  5413

Met Ala Thr Leu Ala Cys Arg Val Gln Phe Leu Asp Asp Thr Asp Pro 
1               5                   10                  15      


Phe Asn Ser Thr Asn Phe Pro Glu Pro Ser Arg Pro Pro Leu Phe Thr 
            20                  25                  30          


Phe Arg Glu Asp Leu Ala Leu Gly Thr Gln Leu Ala Gly Val His Arg 
        35                  40                  45              


Leu Leu Gln Ala Pro His Lys Leu Asp Asp Cys Thr Leu Gln Leu Ser 
    50                  55                  60                  


His Asn Gly Ala Tyr Leu Asp Leu Glu Ala Thr Leu Ala Glu Gln Arg 
65                  70                  75                  80  


Asp Glu Leu Glu Gly Phe Gln Asp Asp Ala Gly Arg Gly Lys Lys His 
                85                  90                  95      


Ser Ile Ile Leu Arg Thr Gln Leu Ser Val Arg Val His Ala Cys Ile 
            100                 105                 110         


Glu Lys Leu Tyr Asn Ser Ser Gly Arg Asp Leu Arg Arg Ala Leu Phe 
        115                 120                 125             


Ser Leu Lys Gln Ile Phe Gln Asp Asp Lys Asp Leu Val His Glu Phe 
    130                 135                 140                 


Val Val Ala Glu Gly Leu Thr Cys Leu Ile Lys Val Gly Ala Glu Ala 
145                 150                 155                 160 


Asp Gln Asn Tyr Gln Asn Tyr Ile Leu Arg Ala Leu Gly Gln Ile Met 
                165                 170                 175     


Leu Tyr Val Asp Gly Met Asn Gly Val Ile Asn Arg Asn Glu Thr Ile 
            180                 185                 190         


Gln Trp Leu Tyr Thr Leu Ile Gly Ser Lys Phe Arg Leu Val Val Lys 
        195                 200                 205             


Thr Ala Leu Lys Leu Leu Leu Val Phe Val Glu Tyr Ser Glu Ser Asn 
    210                 215                 220                 


Ala Pro Leu Leu Ile Gln Ala Val Thr Ala Val Asp Thr Lys Arg Gly 
225                 230                 235                 240 


Val Lys Pro Trp Ser Asn Ile Met Glu Ile Leu Glu Glu Lys Asp Gly 
                245                 250                 255     


Val Asp Thr Glu Leu Leu Val Tyr Ala Met Thr Leu Val Asn Lys Thr 
            260                 265                 270         


Leu Ser Gly Leu Pro Asp Gln Asp Thr Phe Tyr Asp Val Val Asp Cys 
        275                 280                 285             


Leu Glu Glu Leu Gly Ile Ala Ala Val Ser Gln Arg His Leu Asn Lys 
    290                 295                 300                 


Lys Gly Thr Asp Leu Asp Leu Val Glu Gln Leu Asn Ile Tyr Glu Val 
305                 310                 315                 320 


Ala Leu Arg His Glu Asp Gly Asp Glu Thr Thr Glu Pro Pro Pro Ser 
                325                 330                 335     


Gly Cys Arg Asp Arg Arg Arg Ala Ser Val Cys Ser Ser Gly Gly Gly 
            340                 345                 350         


Glu His Arg Gly Leu Asp Arg Arg Arg Ser Arg Arg His Ser Val Gln 
        355                 360                 365             


Ser Ile Lys Ser Thr Leu Ser Ala Pro Thr Ser Pro Cys Ser Gln Ser 
    370                 375                 380                 


Ala Pro Ser Phe Lys Pro Asn Gln Val Arg Asp Leu Arg Glu Lys Tyr 
385                 390                 395                 400 


Ser Asn Phe Gly Asn Asn Ser Tyr His Ser Ser Arg Pro Ser Ser Gly 
                405                 410                 415     


Ser Ser Val Pro Thr Thr Pro Thr Ser Ser Val Ser Pro Pro Gln Glu 
            420                 425                 430         


Ala Arg Leu Glu Arg Ser Ser Pro Ser Gly Leu Leu Thr Ser Ser Phe 
        435                 440                 445             


Arg Gln His Gln Glu Ser Leu Ala Ala Glu Arg Glu Arg Arg Arg Gln 
    450                 455                 460                 


Glu Arg Glu Glu Arg Leu Gln Arg Ile Glu Arg Glu Glu Arg Asn Lys 
465                 470                 475                 480 


Phe Ser Arg Asp Tyr Leu Asp Lys Arg Glu Glu Gln Arg Gln Ala Arg 
                485                 490                 495     


Glu Glu Arg Tyr Lys Tyr Leu Glu Gln Leu Ala Ala Glu Glu His Glu 
            500                 505                 510         


Lys Glu Leu Arg Ser Arg Ser Val Ser Arg Gly Arg Ala Asp Leu Ser 
        515                 520                 525             


Leu Asp Leu Thr Ser Pro Ala Ala Pro Ala Cys Leu Ala Pro Leu Ser 
    530                 535                 540                 


His Ser Pro Ser Ser Ser Asp Ser Gln Glu Ala Leu Thr Val Ser Ala 
545                 550                 555                 560 


Ser Ser Pro Gly Thr Pro His His Pro Gln Ala Ser Ala Gly Asp Pro 
                565                 570                 575     


Glu Pro Glu Ser Glu Ala Glu Pro Glu Ala Glu Ala Gly Ala Gly Gln 
            580                 585                 590         


Val Ala Asp Glu Ala Gly Gln Asp Ile Ala Ser Ala His Glu Gly Ala 
        595                 600                 605             


Glu Thr Glu Val Glu Gln Ala Leu Glu Gln Glu Pro Glu Glu Arg Ala 
    610                 615                 620                 


Ser Leu Ser Glu Lys Glu Arg Gln Asn Glu Gly Val Asn Glu Arg Asp 
625                 630                 635                 640 


Asn Cys Ser Ala Ser Ser Val Ser Ser Ser Ser Ser Thr Leu Glu Arg 
                645                 650                 655     


Glu Glu Lys Glu Asp Lys Leu Ser Arg Asp Arg Thr Thr Gly Leu Trp 
            660                 665                 670         


Pro Ala Gly Val Gln Asp Ala Gly Val Asn Gly Gln Cys Gly Asp Ile 
        675                 680                 685             


Leu Thr Asn Lys Arg Phe Met Leu Asp Met Leu Tyr Ala His Asn Arg 
    690                 695                 700                 


Lys Ser Pro Asp Asp Glu Glu Lys Gly Asp Gly Glu Ala Gly Arg Thr 
705                 710                 715                 720 


Gln Gln Glu Ala Glu Ala Val Ala Ser Leu Ala Thr Arg Ile Ser Thr 
                725                 730                 735     


Leu Gln Ala Asn Ser Gln Thr Gln Asp Glu Ser Val Arg Arg Val Asp 
            740                 745                 750         


Val Gly Cys Leu Asp Asn Arg Gly Ser Val Lys Ala Phe Ala Glu Lys 
        755                 760                 765             


Phe Asn Ser Gly Asp Leu Gly Arg Gly Ser Ile Ser Pro Asp Ala Glu 
    770                 775                 780                 


Pro Asn Asp Lys Val Pro Glu Thr Ala Pro Val Gln Pro Lys Thr Glu 
785                 790                 795                 800 


Ser Asp Tyr Ile Trp Asp Gln Leu Met Ala Asn Pro Arg Glu Leu Arg 
                805                 810                 815     


Ile Gln Asp Met Asp Phe Thr Asp Leu Gly Glu Glu Asp Asp Ile Asp 
            820                 825                 830         


Val Leu Asp Val Asp Leu Gly His Arg Glu Ala Pro Gly Pro Pro Pro 
        835                 840                 845             


Pro Pro Pro Pro Thr Phe Leu Gly Leu Pro Pro Pro Pro Pro Pro Pro 
    850                 855                 860                 


Leu Leu Asp Ser Ile Pro Pro Pro Pro Val Pro Gly Asn Leu Leu Val 
865                 870                 875                 880 


Pro Pro Pro Pro Val Phe Asn Ala Pro Gln Gly Leu Gly Trp Ser Gln 
                885                 890                 895     


Val Pro Arg Gly Gln Pro Thr Phe Thr Lys Lys Lys Lys Thr Ile Arg 
            900                 905                 910         


Leu Phe Trp Asn Glu Val Arg Pro Phe Asp Trp Pro Cys Lys Asn Asn 
        915                 920                 925             


Arg Arg Cys Arg Glu Phe Leu Trp Ser Lys Leu Glu Pro Ile Lys Val 
    930                 935                 940                 


Asp Thr Ser Arg Leu Glu His Leu Phe Glu Ser Lys Ser Lys Glu Leu 
945                 950                 955                 960 


Ser Val Ser Lys Lys Thr Ala Ala Asp Gly Lys Arg Gln Glu Ile Ile 
                965                 970                 975     


Val Leu Asp Ser Lys Arg Ser Asn Ala Ile Asn Ile Gly Leu Thr Val 
            980                 985                 990         


Leu Pro Pro Pro Arg Thr Ile Lys  Ile Ala Ile Leu Asn  Phe Asp Glu 
        995                 1000                 1005             


Tyr Ala  Leu Asn Lys Glu Gly  Ile Glu Lys Ile Leu  Thr Met Ile 
    1010                 1015                 1020             


Pro Thr  Asp Glu Glu Lys Gln  Lys Ile Gln Glu Ala  Gln Leu Ala 
    1025                 1030                 1035             


Asn Pro  Glu Ile Pro Leu Gly  Ser Ala Glu Gln Phe  Leu Leu Thr 
    1040                 1045                 1050             


Leu Ser  Ser Ile Ser Glu Leu  Ser Ala Arg Leu His  Leu Trp Ala 
    1055                 1060                 1065             


Phe Lys  Met Asp Tyr Glu Thr  Thr Glu Lys Glu Val  Ala Glu Pro 
    1070                 1075                 1080             


Leu Leu  Asp Leu Lys Glu Gly  Ile Asp Gln Leu Glu  Asn Asn Lys 
    1085                 1090                 1095             


Thr Leu  Gly Phe Ile Leu Ser  Thr Leu Leu Ala Ile  Gly Asn Phe 
    1100                 1105                 1110             


Leu Asn  Gly Thr Asn Ala Lys  Ala Phe Glu Leu Ser  Tyr Leu Glu 
    1115                 1120                 1125             


Lys Val  Pro Glu Val Lys Asp  Thr Val His Lys Gln  Ser Leu Leu 
    1130                 1135                 1140             


His His  Val Cys Thr Met Val  Val Glu Asn Phe Pro  Asp Ser Ser 
    1145                 1150                 1155             


Asp Leu  Tyr Ser Glu Ile Gly  Ala Ile Thr Arg Ser  Ala Lys Val 
    1160                 1165                 1170             


Asp Phe  Asp Gln Leu Gln Asp  Asn Leu Cys Gln Met  Glu Arg Arg 
    1175                 1180                 1185             


Cys Lys  Ala Ser Trp Asp His  Leu Lys Ala Ile Ala  Lys His Glu 
    1190                 1195                 1200             


Met Lys  Pro Val Leu Lys Gln  Arg Met Ser Glu Phe  Leu Lys Asp 
    1205                 1210                 1215             


Cys Ala  Glu Arg Ile Ile Ile  Leu Lys Ile Val His  Arg Arg Ile 
    1220                 1225                 1230             


Ile Asn  Arg Phe His Ser Phe  Leu Leu Phe Met Gly  His Pro Pro 
    1235                 1240                 1245             


Tyr Ala  Ile Arg Glu Val Asn  Ile Asn Lys Phe Cys  Arg Ile Ile 
    1250                 1255                 1260             


Ser Glu  Phe Ala Leu Glu Tyr  Arg Thr Thr Arg Glu  Arg Val Leu 
    1265                 1270                 1275             


Gln Gln  Lys Gln Lys Arg Ala  Asn His Arg Glu Arg  Asn Lys Thr 
    1280                 1285                 1290             


Arg Gly  Lys Met Ile Thr Asp  Ser Gly Lys Phe Ser  Gly Ser Ser 
    1295                 1300                 1305             


Pro Ala  Pro Pro Ser Gln Pro  Gln Gly Leu Ser Tyr  Ala Glu Asp 
    1310                 1315                 1320             


Ala Ala  Glu His Glu Asn Met  Lys Ala Val Leu Lys  Thr Ser Ser 
    1325                 1330                 1335             


Pro Ser  Val Glu Asp Ala Thr  Pro Ala Leu Gly Val  Arg Thr Arg 
    1340                 1345                 1350             


Ser Arg  Ala Ser Arg Gly Ser  Thr Ser Ser Trp Thr  Met Gly Thr 
    1355                 1360                 1365             


Asp Asp  Ser Pro Asn Val Thr  Asp Asp Ala Ala Asp  Glu Ile Met 
    1370                 1375                 1380             


Asp Arg  Ile Val Lys Ser Ala  Thr Gln Val Pro Ser  Gln Arg Val 
    1385                 1390                 1395             


Val Pro  Arg Glu Arg Lys Arg  Ser Arg Ala Asn Arg  Lys Ser Leu 
    1400                 1405                 1410             


Arg Arg  Thr Leu Lys Ser Gly  Leu Thr Pro Glu Glu  Ala Arg Ala 
    1415                 1420                 1425             


Leu Gly  Leu Val Gly Thr Ser  Glu Leu Gln Leu 
    1430                 1435                 


<210>  5414
<211>  1422
<212>  PRT
<213>  Homo Sapiens

<400>  5414

Met Ala Thr Leu Ala Cys Arg Val Gln Phe Leu Asp Asp Thr Asp Pro 
1               5                   10                  15      


Phe Asn Ser Thr Asn Phe Pro Glu Pro Ser Arg Pro Pro Leu Phe Thr 
            20                  25                  30          


Phe Arg Glu Asp Leu Ala Leu Gly Thr Gln Leu Ala Gly Val His Arg 
        35                  40                  45              


Leu Leu Gln Ala Pro His Lys Leu Asp Asp Cys Thr Leu Gln Leu Ser 
    50                  55                  60                  


His Asn Gly Ala Tyr Leu Asp Leu Glu Ala Thr Leu Ala Glu Gln Arg 
65                  70                  75                  80  


Asp Glu Leu Glu Gly Phe Gln Asp Asp Ala Gly Arg Gly Lys Lys His 
                85                  90                  95      


Ser Ile Ile Leu Arg Thr Gln Leu Ser Val Arg Val His Ala Cys Ile 
            100                 105                 110         


Glu Lys Leu Tyr Asn Ser Ser Gly Arg Asp Leu Arg Arg Ala Leu Phe 
        115                 120                 125             


Ser Leu Lys Gln Ile Phe Gln Asp Asp Lys Asp Leu Val His Glu Phe 
    130                 135                 140                 


Val Val Ala Glu Gly Leu Thr Cys Leu Ile Lys Val Gly Ala Glu Ala 
145                 150                 155                 160 


Asp Gln Asn Tyr Gln Asn Tyr Ile Leu Arg Ala Leu Gly Gln Ile Met 
                165                 170                 175     


Leu Tyr Val Asp Gly Met Asn Gly Val Ile Asn Arg Asn Glu Thr Ile 
            180                 185                 190         


Gln Trp Leu Tyr Thr Leu Ile Gly Ser Lys Phe Arg Leu Val Val Lys 
        195                 200                 205             


Thr Ala Leu Lys Leu Leu Leu Val Phe Val Glu Tyr Ser Glu Ser Asn 
    210                 215                 220                 


Ala Pro Leu Leu Ile Gln Ala Val Thr Ala Val Asp Thr Lys Arg Gly 
225                 230                 235                 240 


Val Lys Pro Trp Ser Asn Ile Met Glu Ile Leu Glu Glu Lys Asp Gly 
                245                 250                 255     


Val Asp Thr Glu Leu Leu Val Tyr Ala Met Thr Leu Val Asn Lys Thr 
            260                 265                 270         


Leu Ser Gly Leu Pro Asp Gln Asp Thr Phe Tyr Asp Val Val Asp Cys 
        275                 280                 285             


Leu Glu Glu Leu Gly Ile Ala Ala Val Ser Gln Arg His Leu Asn Lys 
    290                 295                 300                 


Lys Gly Thr Asp Leu Asp Leu Val Glu Gln Leu Asn Ile Tyr Glu Val 
305                 310                 315                 320 


Ala Leu Arg His Glu Asp Gly Asp Glu Thr Thr Glu Pro Pro Pro Ser 
                325                 330                 335     


Gly Cys Arg Asp Arg Arg Arg Ala Ser Val Cys Ser Ser Gly Gly Gly 
            340                 345                 350         


Glu His Arg Gly Leu Asp Arg Arg Arg Ser Arg Arg His Ser Val Gln 
        355                 360                 365             


Ser Ile Lys Ser Thr Leu Ser Ala Pro Thr Ser Pro Cys Ser Gln Ser 
    370                 375                 380                 


Ala Pro Ser Phe Lys Pro Asn Gln Val Arg Asp Leu Arg Glu Lys Tyr 
385                 390                 395                 400 


Ser Asn Phe Gly Asn Asn Ser Tyr His Ser Ser Arg Pro Ser Ser Gly 
                405                 410                 415     


Ser Ser Val Pro Thr Thr Pro Thr Ser Ser Val Ser Pro Pro Gln Glu 
            420                 425                 430         


Ala Arg Leu Glu Arg Ser Ser Pro Ser Gly Leu Leu Thr Ser Ser Phe 
        435                 440                 445             


Arg Gln His Gln Glu Ser Leu Ala Ala Glu Arg Glu Arg Arg Arg Gln 
    450                 455                 460                 


Glu Arg Glu Glu Arg Leu Gln Arg Ile Glu Arg Glu Glu Arg Asn Lys 
465                 470                 475                 480 


Phe Arg Tyr Lys Tyr Leu Glu Gln Leu Ala Ala Glu Glu His Glu Lys 
                485                 490                 495     


Glu Leu Arg Ser Arg Ser Val Ser Arg Gly Arg Ala Asp Leu Ser Leu 
            500                 505                 510         


Asp Leu Thr Ser Pro Ala Ala Pro Ala Cys Leu Ala Pro Leu Ser His 
        515                 520                 525             


Ser Pro Ser Ser Ser Asp Ser Gln Glu Ala Leu Thr Val Ser Ala Ser 
    530                 535                 540                 


Ser Pro Gly Thr Pro His His Pro Gln Ala Ser Ala Gly Asp Pro Glu 
545                 550                 555                 560 


Pro Glu Ser Glu Ala Glu Pro Glu Ala Glu Ala Gly Ala Gly Gln Val 
                565                 570                 575     


Ala Asp Glu Ala Gly Gln Asp Ile Ala Ser Ala His Glu Gly Ala Glu 
            580                 585                 590         


Thr Glu Val Glu Gln Ala Leu Glu Gln Glu Pro Glu Glu Arg Ala Ser 
        595                 600                 605             


Leu Ser Glu Lys Glu Arg Gln Asn Glu Gly Val Asn Glu Arg Asp Asn 
    610                 615                 620                 


Cys Ser Ala Ser Ser Val Ser Ser Ser Ser Ser Thr Leu Glu Arg Glu 
625                 630                 635                 640 


Glu Lys Glu Asp Lys Leu Ser Arg Asp Arg Thr Thr Gly Leu Trp Pro 
                645                 650                 655     


Ala Gly Val Gln Asp Ala Gly Val Asn Gly Gln Cys Gly Asp Ile Leu 
            660                 665                 670         


Thr Asn Lys Arg Phe Met Leu Asp Met Leu Tyr Ala His Asn Arg Lys 
        675                 680                 685             


Ser Pro Asp Asp Glu Glu Lys Gly Asp Gly Glu Ala Gly Arg Thr Gln 
    690                 695                 700                 


Gln Glu Ala Glu Ala Val Ala Ser Leu Ala Thr Arg Ile Ser Thr Leu 
705                 710                 715                 720 


Gln Ala Asn Ser Gln Thr Gln Asp Glu Ser Val Arg Arg Val Asp Val 
                725                 730                 735     


Gly Cys Leu Asp Asn Arg Gly Ser Val Lys Ala Phe Ala Glu Lys Phe 
            740                 745                 750         


Asn Ser Gly Asp Leu Gly Arg Gly Ser Ile Ser Pro Asp Ala Glu Pro 
        755                 760                 765             


Asn Asp Lys Val Pro Glu Thr Ala Pro Val Gln Pro Lys Thr Glu Ser 
    770                 775                 780                 


Asp Tyr Ile Trp Asp Gln Leu Met Ala Asn Pro Arg Glu Leu Arg Ile 
785                 790                 795                 800 


Gln Asp Met Asp Phe Thr Asp Leu Gly Glu Glu Asp Asp Ile Asp Val 
                805                 810                 815     


Leu Asp Val Asp Leu Gly His Arg Glu Ala Pro Gly Pro Pro Pro Pro 
            820                 825                 830         


Pro Pro Pro Thr Phe Leu Gly Leu Pro Pro Pro Pro Pro Pro Pro Leu 
        835                 840                 845             


Leu Asp Ser Ile Pro Pro Pro Pro Val Pro Gly Asn Leu Leu Val Pro 
    850                 855                 860                 


Pro Pro Pro Val Phe Asn Ala Pro Gln Gly Leu Gly Trp Ser Gln Val 
865                 870                 875                 880 


Pro Arg Gly Gln Pro Thr Phe Thr Lys Lys Lys Lys Thr Ile Arg Leu 
                885                 890                 895     


Phe Trp Asn Glu Val Arg Pro Phe Asp Trp Pro Cys Lys Asn Asn Arg 
            900                 905                 910         


Arg Cys Arg Glu Phe Leu Trp Ser Lys Leu Glu Pro Ile Lys Val Asp 
        915                 920                 925             


Thr Ser Arg Leu Glu His Leu Phe Glu Ser Lys Ser Lys Glu Leu Ser 
    930                 935                 940                 


Val Ser Lys Lys Thr Ala Ala Asp Gly Lys Arg Gln Glu Ile Ile Val 
945                 950                 955                 960 


Leu Asp Ser Lys Arg Ser Asn Ala Ile Asn Ile Gly Leu Thr Val Leu 
                965                 970                 975     


Pro Pro Pro Arg Thr Ile Lys Ile Ala Ile Leu Asn Phe Asp Glu Tyr 
            980                 985                 990         


Ala Leu Asn Lys Glu Gly Ile Glu  Lys Ile Leu Thr Met  Ile Pro Thr 
        995                 1000                 1005             


Asp Glu  Glu Lys Gln Lys Ile  Gln Glu Ala Gln Leu  Ala Asn Pro 
    1010                 1015                 1020             


Glu Ile  Pro Leu Gly Ser Ala  Glu Gln Phe Leu Leu  Thr Leu Ser 
    1025                 1030                 1035             


Ser Ile  Ser Glu Leu Ser Ala  Arg Leu His Leu Trp  Ala Phe Lys 
    1040                 1045                 1050             


Met Asp  Tyr Glu Thr Thr Glu  Lys Glu Val Ala Glu  Pro Leu Leu 
    1055                 1060                 1065             


Asp Leu  Lys Glu Gly Ile Asp  Gln Leu Glu Asn Asn  Lys Thr Leu 
    1070                 1075                 1080             


Gly Phe  Ile Leu Ser Thr Leu  Leu Ala Ile Gly Asn  Phe Leu Asn 
    1085                 1090                 1095             


Gly Thr  Asn Ala Lys Ala Phe  Glu Leu Ser Tyr Leu  Glu Lys Val 
    1100                 1105                 1110             


Pro Glu  Val Lys Asp Thr Val  His Lys Gln Ser Leu  Leu His His 
    1115                 1120                 1125             


Val Cys  Thr Met Val Val Glu  Asn Phe Pro Asp Ser  Ser Asp Leu 
    1130                 1135                 1140             


Tyr Ser  Glu Ile Gly Ala Ile  Thr Arg Ser Ala Lys  Val Asp Phe 
    1145                 1150                 1155             


Asp Gln  Leu Gln Asp Asn Leu  Cys Gln Met Glu Arg  Arg Cys Lys 
    1160                 1165                 1170             


Ala Ser  Trp Asp His Leu Lys  Ala Ile Ala Lys His  Glu Met Lys 
    1175                 1180                 1185             


Pro Val  Leu Lys Gln Arg Met  Ser Glu Phe Leu Lys  Asp Cys Ala 
    1190                 1195                 1200             


Glu Arg  Ile Ile Ile Leu Lys  Ile Val His Arg Arg  Ile Ile Asn 
    1205                 1210                 1215             


Arg Phe  His Ser Phe Leu Leu  Phe Met Gly His Pro  Pro Tyr Ala 
    1220                 1225                 1230             


Ile Arg  Glu Val Asn Ile Asn  Lys Phe Cys Arg Ile  Ile Ser Glu 
    1235                 1240                 1245             


Phe Ala  Leu Glu Tyr Arg Thr  Thr Arg Glu Arg Val  Leu Gln Gln 
    1250                 1255                 1260             


Lys Gln  Lys Arg Ala Asn His  Arg Glu Arg Asn Lys  Thr Arg Gly 
    1265                 1270                 1275             


Lys Met  Ile Thr Asp Ser Gly  Lys Phe Ser Gly Ser  Ser Pro Ala 
    1280                 1285                 1290             


Pro Pro  Ser Gln Pro Gln Gly  Leu Ser Tyr Ala Glu  Asp Ala Ala 
    1295                 1300                 1305             


Glu His  Glu Asn Met Lys Ala  Val Leu Lys Thr Ser  Ser Pro Ser 
    1310                 1315                 1320             


Val Glu  Asp Ala Thr Pro Ala  Leu Gly Val Arg Thr  Arg Ser Arg 
    1325                 1330                 1335             


Ala Ser  Arg Gly Ser Thr Ser  Ser Trp Thr Met Gly  Thr Asp Asp 
    1340                 1345                 1350             


Ser Pro  Asn Val Thr Asp Asp  Ala Ala Asp Glu Ile  Met Asp Arg 
    1355                 1360                 1365             


Ile Val  Lys Ser Ala Thr Gln  Val Pro Ser Gln Arg  Val Val Pro 
    1370                 1375                 1380             


Arg Glu  Arg Lys Arg Ser Arg  Ala Asn Arg Lys Ser  Leu Arg Arg 
    1385                 1390                 1395             


Thr Leu  Lys Ser Gly Leu Thr  Pro Glu Glu Ala Arg  Ala Leu Gly 
    1400                 1405                 1410             


Leu Val  Gly Thr Ser Glu Leu  Gln Leu 
    1415                 1420         


<210>  5415
<211>  1622
<212>  PRT
<213>  Homo Sapiens

<400>  5415

Met Ala Thr Leu Ala Cys Arg Val Gln Phe Leu Asp Asp Thr Asp Pro 
1               5                   10                  15      


Phe Asn Ser Thr Asn Phe Pro Glu Pro Ser Arg Pro Pro Leu Phe Thr 
            20                  25                  30          


Phe Arg Glu Asp Leu Ala Leu Gly Thr Gln Leu Ala Gly Val His Arg 
        35                  40                  45              


Leu Leu Gln Ala Pro His Lys Leu Asp Asp Cys Thr Leu Gln Leu Ser 
    50                  55                  60                  


His Asn Gly Ala Tyr Leu Asp Leu Glu Ala Thr Leu Ala Glu Gln Arg 
65                  70                  75                  80  


Asp Glu Leu Glu Gly Phe Gln Asp Asp Ala Gly Arg Gly Lys Lys His 
                85                  90                  95      


Ser Ile Ile Leu Arg Thr Gln Leu Ser Val Arg Val His Ala Cys Ile 
            100                 105                 110         


Glu Lys Leu Tyr Asn Ser Ser Gly Arg Asp Leu Arg Arg Ala Leu Phe 
        115                 120                 125             


Ser Leu Lys Gln Ile Phe Gln Asp Asp Lys Asp Leu Val His Glu Phe 
    130                 135                 140                 


Val Val Ala Glu Gly Leu Thr Cys Leu Ile Lys Val Gly Ala Glu Ala 
145                 150                 155                 160 


Asp Gln Asn Tyr Gln Asn Tyr Ile Leu Arg Ala Leu Gly Gln Ile Met 
                165                 170                 175     


Leu Tyr Val Asp Gly Met Asn Gly Val Ile Asn Arg Asn Glu Thr Ile 
            180                 185                 190         


Gln Trp Leu Tyr Thr Leu Ile Gly Ser Lys Phe Arg Leu Val Val Lys 
        195                 200                 205             


Thr Ala Leu Lys Leu Leu Leu Val Phe Val Glu Tyr Ser Glu Ser Asn 
    210                 215                 220                 


Ala Pro Leu Leu Ile Gln Ala Val Thr Ala Val Asp Thr Lys Arg Gly 
225                 230                 235                 240 


Val Lys Pro Trp Ser Asn Ile Met Glu Ile Leu Glu Glu Lys Asp Gly 
                245                 250                 255     


Val Asp Thr Glu Leu Leu Val Tyr Ala Met Thr Leu Val Asn Lys Thr 
            260                 265                 270         


Leu Ser Gly Leu Pro Asp Gln Asp Thr Phe Tyr Asp Val Val Asp Cys 
        275                 280                 285             


Leu Glu Glu Leu Gly Ile Ala Ala Val Ser Gln Arg His Leu Asn Lys 
    290                 295                 300                 


Lys Gly Thr Asp Leu Asp Leu Val Glu Gln Leu Asn Ile Tyr Glu Val 
305                 310                 315                 320 


Ala Leu Arg His Glu Asp Gly Asp Glu Thr Thr Glu Pro Pro Pro Ser 
                325                 330                 335     


Gly Cys Arg Asp Arg Arg Arg Ala Ser Val Cys Ser Ser Gly Gly Gly 
            340                 345                 350         


Glu His Arg Gly Leu Asp Arg Arg Arg Ser Arg Arg His Ser Val Gln 
        355                 360                 365             


Ser Ile Lys Ser Thr Leu Ser Ala Pro Thr Ser Pro Cys Ser Gln Ser 
    370                 375                 380                 


Ala Pro Ser Phe Lys Pro Asn Gln Val Arg Asp Leu Arg Glu Lys Glu 
385                 390                 395                 400 


Glu Glu Glu Glu Glu Glu Gln Pro Ile Thr Glu Pro Ser Ser Glu Glu 
                405                 410                 415     


Glu Arg Glu Asp Asp Ala Ser Cys Gln Gly Lys Asp Ser Lys Val Gly 
            420                 425                 430         


Ala Ala Ser Gly Gln Ser Pro Thr Gly Arg Asp Ala Ala Pro Lys Ser 
        435                 440                 445             


Ser Ala Leu Pro Ala Val Ser Asn Ala Ser Ser Gln Gly Lys Pro Leu 
    450                 455                 460                 


Leu Val Gly Thr Ala Gly Gly Thr Thr Trp His Ser Gly Ser Ser Gly 
465                 470                 475                 480 


Ser Glu Ala Thr Pro Ser Ala Leu Leu Ser Pro Pro Ala Ser Ala Ala 
                485                 490                 495     


Arg Pro Ser Ser Ala Thr Pro Gly Ser Leu Lys Val Ser Pro Thr Ile 
            500                 505                 510         


Asp Lys Leu Pro Tyr Val Pro His Ser Pro Phe His Leu Phe Ser Tyr 
        515                 520                 525             


Asp Phe Glu Asp Ser Ser Leu Ser Thr Lys Glu Lys Glu Ala Glu Ser 
    530                 535                 540                 


Gln Lys Glu Asn Ser Ser Ser Asp Ser Phe Ser Leu Ser Thr Tyr Ser 
545                 550                 555                 560 


Ala Ser Glu Pro Tyr His Phe Arg Ser Phe Ser Ser Asn Arg Tyr Ser 
                565                 570                 575     


Asn Phe Gly Asn Asn Ser Tyr His Ser Ser Arg Pro Ser Ser Gly Ser 
            580                 585                 590         


Ser Val Pro Thr Thr Pro Thr Ser Ser Val Ser Pro Pro Gln Glu Ala 
        595                 600                 605             


Arg Leu Glu Arg Ser Ser Pro Ser Gly Leu Leu Thr Ser Ser Phe Arg 
    610                 615                 620                 


Gln His Gln Glu Ser Leu Ala Ala Glu Arg Glu Arg Arg Arg Gln Glu 
625                 630                 635                 640 


Arg Glu Glu Arg Leu Gln Arg Ile Glu Arg Glu Glu Arg Asn Lys Phe 
                645                 650                 655     


Ser Arg Asp Tyr Leu Asp Lys Arg Glu Glu Gln Arg Gln Ala Arg Glu 
            660                 665                 670         


Glu Arg Tyr Lys Tyr Leu Glu Gln Leu Ala Ala Glu Glu His Glu Lys 
        675                 680                 685             


Glu Leu Arg Ser Arg Ser Val Ser Arg Gly Arg Ala Asp Leu Ser Leu 
    690                 695                 700                 


Asp Leu Thr Ser Pro Ala Ala Pro Ala Cys Leu Ala Pro Leu Ser His 
705                 710                 715                 720 


Ser Pro Ser Ser Ser Asp Ser Gln Glu Ala Leu Thr Val Ser Ala Ser 
                725                 730                 735     


Ser Pro Gly Thr Pro His His Pro Gln Ala Ser Ala Gly Asp Pro Glu 
            740                 745                 750         


Pro Glu Ser Glu Ala Glu Pro Glu Ala Glu Ala Gly Ala Gly Gln Val 
        755                 760                 765             


Ala Asp Glu Ala Gly Gln Asp Ile Ala Ser Ala His Glu Gly Ala Glu 
    770                 775                 780                 


Thr Glu Val Glu Gln Ala Leu Glu Gln Glu Pro Glu Glu Arg Ala Ser 
785                 790                 795                 800 


Leu Ser Glu Lys Glu Arg Gln Asn Glu Gly Val Asn Glu Arg Asp Asn 
                805                 810                 815     


Cys Ser Ala Ser Ser Val Ser Ser Ser Ser Ser Thr Leu Glu Arg Glu 
            820                 825                 830         


Glu Lys Glu Asp Lys Leu Ser Arg Asp Arg Thr Thr Gly Leu Trp Pro 
        835                 840                 845             


Ala Gly Val Gln Asp Ala Gly Val Asn Gly Gln Cys Gly Asp Ile Leu 
    850                 855                 860                 


Thr Asn Lys Arg Phe Met Leu Asp Met Leu Tyr Ala His Asn Arg Lys 
865                 870                 875                 880 


Ser Pro Asp Asp Glu Glu Lys Gly Asp Gly Glu Ala Gly Arg Thr Gln 
                885                 890                 895     


Gln Glu Ala Glu Ala Val Ala Ser Leu Ala Thr Arg Ile Ser Thr Leu 
            900                 905                 910         


Gln Ala Asn Ser Gln Thr Gln Asp Glu Ser Val Arg Arg Val Asp Val 
        915                 920                 925             


Gly Cys Leu Asp Asn Arg Gly Ser Val Lys Ala Phe Ala Glu Lys Phe 
    930                 935                 940                 


Asn Ser Gly Asp Leu Gly Arg Gly Ser Ile Ser Pro Asp Ala Glu Pro 
945                 950                 955                 960 


Asn Asp Lys Val Pro Glu Thr Ala Pro Val Gln Pro Lys Thr Glu Ser 
                965                 970                 975     


Asp Tyr Ile Trp Asp Gln Leu Met Ala Asn Pro Arg Glu Leu Arg Ile 
            980                 985                 990         


Gln Asp Met Asp Phe Thr Asp Leu  Gly Glu Glu Asp Asp  Ile Asp Val 
        995                 1000                 1005             


Leu Asp  Val Asp Leu Gly His  Arg Glu Ala Pro Gly  Pro Pro Pro 
    1010                 1015                 1020             


Pro Pro  Pro Pro Thr Phe Leu  Gly Leu Pro Pro Pro  Pro Pro Pro 
    1025                 1030                 1035             


Pro Leu  Leu Asp Ser Ile Pro  Pro Pro Pro Val Pro  Gly Asn Leu 
    1040                 1045                 1050             


Leu Val  Pro Pro Pro Pro Val  Phe Asn Ala Pro Gln  Gly Leu Gly 
    1055                 1060                 1065             


Trp Ser  Gln Val Pro Arg Gly  Gln Pro Thr Phe Thr  Lys Lys Lys 
    1070                 1075                 1080             


Lys Thr  Ile Arg Leu Phe Trp  Asn Glu Val Arg Pro  Phe Asp Trp 
    1085                 1090                 1095             


Pro Cys  Lys Asn Asn Arg Arg  Cys Arg Glu Phe Leu  Trp Ser Lys 
    1100                 1105                 1110             


Leu Glu  Pro Ile Lys Val Asp  Thr Ser Arg Leu Glu  His Leu Phe 
    1115                 1120                 1125             


Glu Ser  Lys Ser Lys Glu Leu  Ser Val Ser Lys Lys  Thr Ala Ala 
    1130                 1135                 1140             


Asp Gly  Lys Arg Gln Glu Ile  Ile Val Leu Asp Ser  Lys Arg Ser 
    1145                 1150                 1155             


Asn Ala  Ile Asn Ile Gly Leu  Thr Val Leu Pro Pro  Pro Arg Thr 
    1160                 1165                 1170             


Ile Lys  Ile Ala Ile Leu Asn  Phe Asp Glu Tyr Ala  Leu Asn Lys 
    1175                 1180                 1185             


Glu Gly  Ile Glu Lys Ile Leu  Thr Met Ile Pro Thr  Asp Glu Glu 
    1190                 1195                 1200             


Lys Gln  Lys Ile Gln Glu Ala  Gln Leu Ala Asn Pro  Glu Ile Pro 
    1205                 1210                 1215             


Leu Gly  Ser Ala Glu Gln Phe  Leu Leu Thr Leu Ser  Ser Ile Ser 
    1220                 1225                 1230             


Glu Leu  Ser Ala Arg Leu His  Leu Trp Ala Phe Lys  Met Asp Tyr 
    1235                 1240                 1245             


Glu Thr  Thr Glu Lys Glu Val  Ala Glu Pro Leu Leu  Asp Leu Lys 
    1250                 1255                 1260             


Glu Gly  Ile Asp Gln Leu Glu  Asn Asn Lys Thr Leu  Gly Phe Ile 
    1265                 1270                 1275             


Leu Ser  Thr Leu Leu Ala Ile  Gly Asn Phe Leu Asn  Gly Thr Asn 
    1280                 1285                 1290             


Ala Lys  Ala Phe Glu Leu Ser  Tyr Leu Glu Lys Val  Pro Glu Val 
    1295                 1300                 1305             


Lys Asp  Thr Val His Lys Gln  Ser Leu Leu His His  Val Cys Thr 
    1310                 1315                 1320             


Met Val  Val Glu Asn Phe Pro  Asp Ser Ser Asp Leu  Tyr Ser Glu 
    1325                 1330                 1335             


Ile Gly  Ala Ile Thr Arg Ser  Ala Lys Val Asp Phe  Asp Gln Leu 
    1340                 1345                 1350             


Gln Asp  Asn Leu Cys Gln Met  Glu Arg Arg Cys Lys  Ala Ser Trp 
    1355                 1360                 1365             


Asp His  Leu Lys Ala Ile Ala  Lys His Glu Met Lys  Pro Val Leu 
    1370                 1375                 1380             


Lys Gln  Arg Met Ser Glu Phe  Leu Lys Asp Cys Ala  Glu Arg Ile 
    1385                 1390                 1395             


Ile Ile  Leu Lys Ile Val His  Arg Arg Ile Ile Asn  Arg Phe His 
    1400                 1405                 1410             


Ser Phe  Leu Leu Phe Met Gly  His Pro Pro Tyr Ala  Ile Arg Glu 
    1415                 1420                 1425             


Val Asn  Ile Asn Lys Phe Cys  Arg Ile Ile Ser Glu  Phe Ala Leu 
    1430                 1435                 1440             


Glu Tyr  Arg Thr Thr Arg Glu  Arg Val Leu Gln Gln  Lys Gln Lys 
    1445                 1450                 1455             


Arg Ala  Asn His Arg Glu Arg  Asn Lys Thr Arg Gly  Lys Met Ile 
    1460                 1465                 1470             


Thr Asp  Thr Asp Glu Glu Glu  Glu Val Glu Ser Gly  Lys Phe Ser 
    1475                 1480                 1485             


Gly Ser  Ser Pro Ala Pro Pro  Ser Gln Pro Gln Gly  Leu Ser Tyr 
    1490                 1495                 1500             


Ala Glu  Asp Ala Ala Glu His  Glu Asn Met Lys Ala  Val Leu Lys 
    1505                 1510                 1515             


Thr Ser  Ser Pro Ser Val Glu  Asp Ala Thr Pro Ala  Leu Gly Val 
    1520                 1525                 1530             


Arg Thr  Arg Ser Arg Ala Ser  Arg Gly Ser Thr Ser  Ser Trp Thr 
    1535                 1540                 1545             


Met Gly  Thr Asp Asp Ser Pro  Asn Val Thr Asp Asp  Ala Ala Asp 
    1550                 1555                 1560             


Glu Ile  Met Asp Arg Ile Val  Lys Ser Ala Thr Gln  Val Pro Ser 
    1565                 1570                 1575             


Gln Arg  Val Val Pro Arg Glu  Arg Lys Arg Ser Arg  Ala Asn Arg 
    1580                 1585                 1590             


Lys Ser  Leu Arg Arg Thr Leu  Lys Ser Gly Leu Thr  Pro Glu Glu 
    1595                 1600                 1605             


Ala Arg  Ala Leu Gly Leu Val  Gly Thr Ser Glu Leu  Gln Leu 
    1610                 1615                 1620         


<210>  5416
<211>  528
<212>  PRT
<213>  Homo Sapiens

<400>  5416

Arg Leu Phe Trp Asn Glu Val Arg Pro Phe Asp Trp Pro Cys Lys Asn 
1               5                   10                  15      


Asn Arg Arg Cys Arg Glu Phe Leu Trp Ser Lys Leu Glu Pro Ile Lys 
            20                  25                  30          


Val Asp Thr Ser Arg Leu Glu His Leu Phe Glu Ser Lys Ser Lys Glu 
        35                  40                  45              


Leu Ser Val Ser Lys Lys Thr Ala Ala Asp Gly Lys Arg Gln Glu Ile 
    50                  55                  60                  


Ile Val Leu Asp Ser Lys Arg Ser Asn Ala Ile Asn Ile Gly Leu Thr 
65                  70                  75                  80  


Val Leu Pro Pro Pro Arg Thr Ile Lys Ile Ala Ile Leu Asn Phe Asp 
                85                  90                  95      


Glu Tyr Ala Leu Asn Lys Glu Gly Ile Glu Lys Ile Leu Thr Met Ile 
            100                 105                 110         


Pro Thr Asp Glu Glu Lys Gln Lys Ile Gln Glu Ala Gln Leu Ala Asn 
        115                 120                 125             


Pro Glu Ile Pro Leu Gly Ser Ala Glu Gln Phe Leu Leu Thr Leu Ser 
    130                 135                 140                 


Ser Ile Ser Glu Leu Ser Ala Arg Leu His Leu Trp Ala Phe Lys Met 
145                 150                 155                 160 


Asp Tyr Glu Thr Thr Glu Lys Glu Val Ala Glu Pro Leu Leu Asp Leu 
                165                 170                 175     


Lys Glu Gly Ile Asp Gln Leu Glu Asn Asn Lys Thr Leu Gly Phe Ile 
            180                 185                 190         


Leu Ser Thr Leu Leu Ala Ile Gly Asn Phe Leu Asn Gly Thr Asn Ala 
        195                 200                 205             


Lys Ala Phe Glu Leu Ser Tyr Leu Glu Lys Val Pro Glu Val Lys Asp 
    210                 215                 220                 


Thr Val His Lys Gln Ser Leu Leu His His Val Cys Thr Met Val Val 
225                 230                 235                 240 


Glu Asn Phe Pro Asp Ser Ser Asp Leu Tyr Ser Glu Ile Gly Ala Ile 
                245                 250                 255     


Thr Arg Ser Ala Lys Val Asp Phe Asp Gln Leu Gln Asp Asn Leu Cys 
            260                 265                 270         


Gln Met Glu Arg Arg Cys Lys Ala Ser Trp Asp His Leu Lys Ala Ile 
        275                 280                 285             


Ala Lys His Glu Met Lys Pro Val Leu Lys Gln Arg Met Ser Glu Phe 
    290                 295                 300                 


Leu Lys Asp Cys Ala Glu Arg Ile Ile Ile Leu Lys Ile Val His Arg 
305                 310                 315                 320 


Arg Ile Ile Asn Arg Phe His Ser Phe Leu Leu Phe Met Gly His Pro 
                325                 330                 335     


Pro Tyr Ala Ile Arg Glu Val Asn Ile Asn Lys Phe Cys Arg Ile Ile 
            340                 345                 350         


Ser Glu Phe Ala Leu Glu Tyr Arg Thr Thr Arg Glu Arg Val Leu Gln 
        355                 360                 365             


Gln Lys Gln Lys Arg Ala Asn His Arg Glu Arg Asn Lys Thr Arg Gly 
    370                 375                 380                 


Lys Met Ile Thr Asp Ser Gly Lys Phe Ser Gly Ser Ser Pro Ala Pro 
385                 390                 395                 400 


Pro Ser Gln Pro Gln Gly Leu Ser Tyr Ala Glu Asp Ala Ala Glu His 
                405                 410                 415     


Glu Asn Met Lys Ala Val Leu Lys Thr Ser Ser Pro Ser Val Glu Asp 
            420                 425                 430         


Ala Thr Pro Ala Leu Gly Val Arg Thr Arg Ser Arg Ala Ser Arg Gly 
        435                 440                 445             


Ser Thr Ser Ser Trp Thr Met Gly Thr Asp Asp Ser Pro Asn Val Thr 
    450                 455                 460                 


Asp Asp Ala Ala Asp Glu Ile Met Asp Arg Ile Val Lys Ser Ala Thr 
465                 470                 475                 480 


Gln Val Pro Ser Gln Arg Val Val Pro Arg Glu Arg Lys Arg Ser Arg 
                485                 490                 495     


Ala Asn Arg Lys Ser Leu Arg Arg Thr Leu Lys Ser Gly Leu Thr Pro 
            500                 505                 510         


Glu Glu Ala Arg Ala Leu Gly Leu Val Gly Thr Ser Glu Leu Gln Leu 
        515                 520                 525             


<210>  5417
<211>  375
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5417

Xaa Ala Ile Asn Ile Gly Leu Thr Val Leu Pro Pro Pro Arg Thr Ile 
1               5                   10                  15      


Lys Ile Ala Ile Leu Asn Phe Asp Glu Tyr Ala Leu Asn Lys Glu Gly 
            20                  25                  30          


Ile Glu Lys Ile Leu Thr Met Ile Pro Thr Asp Glu Glu Lys Gln Lys 
        35                  40                  45              


Ile Gln Glu Ala Gln Leu Ala Asn Pro Glu Ile Pro Leu Gly Ser Ala 
    50                  55                  60                  


Glu Gln Phe Leu Leu Thr Leu Ser Ser Ile Ser Glu Leu Ser Ala Arg 
65                  70                  75                  80  


Leu His Leu Trp Ala Phe Lys Met Asp Tyr Glu Thr Thr Glu Lys Glu 
                85                  90                  95      


Val Ala Glu Pro Leu Leu Asp Leu Lys Glu Gly Ile Asp Gln Leu Glu 
            100                 105                 110         


Asn Asn Lys Thr Leu Gly Phe Ile Leu Ser Thr Leu Leu Ala Ile Gly 
        115                 120                 125             


Asn Phe Leu Asn Gly Thr Asn Ala Lys Ala Phe Glu Leu Ser Tyr Leu 
    130                 135                 140                 


Glu Lys Val Pro Glu Val Lys Asp Thr Val His Lys Gln Ser Leu Leu 
145                 150                 155                 160 


His His Val Cys Thr Met Val Val Glu Asn Phe Pro Asp Ser Ser Asp 
                165                 170                 175     


Leu Tyr Ser Glu Ile Gly Ala Ile Thr Arg Ser Ala Lys Val Asp Phe 
            180                 185                 190         


Asp Gln Leu Gln Asp Asn Leu Cys Gln Met Glu Arg Arg Cys Lys Ala 
        195                 200                 205             


Ser Trp Asp His Leu Lys Ala Ile Ala Lys His Glu Met Lys Pro Val 
    210                 215                 220                 


Leu Lys Gln Arg Met Ser Glu Phe Leu Lys Asp Cys Ala Glu Arg Ile 
225                 230                 235                 240 


Ile Ile Leu Lys Ile Val His Arg Arg Ile Ile Asn Arg Phe His Ser 
                245                 250                 255     


Phe Leu Leu Phe Met Gly His Pro Pro Tyr Ala Ile Arg Glu Val Asn 
            260                 265                 270         


Ile Asn Lys Phe Cys Arg Ile Ile Ser Glu Phe Ala Leu Glu Tyr Arg 
        275                 280                 285             


Thr Thr Arg Glu Arg Val Leu Gln Gln Lys Gln Lys Arg Ala Asn His 
    290                 295                 300                 


Arg Glu Arg Asn Lys Thr Arg Gly Lys Met Ile Thr Asp Asp Pro Leu 
305                 310                 315                 320 


Val Pro Gly Leu Trp Glu Leu Met Thr Arg Pro Met Ser Gln Met Met 
                325                 330                 335     


Gln Leu Met Arg Ser Trp Thr Ala Ser Ser Ser Gln Pro Pro Lys Cys 
            340                 345                 350         


Pro Val Ser Glu Trp Cys Arg Gly Arg Gly Asn Asp Pro Gly Pro Thr 
        355                 360                 365             


Gly Asn Leu Cys Glu Glu Pro 
    370                 375 


<210>  5418
<211>  1200
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5418

Xaa Phe Arg Leu Val Val Lys Thr Ala Leu Lys Leu Leu Leu Val Phe 
1               5                   10                  15      


Val Glu Tyr Ser Glu Ser Asn Ala Pro Leu Leu Ile Gln Ala Val Thr 
            20                  25                  30          


Ala Val Asp Thr Lys Arg Gly Val Lys Pro Trp Ser Asn Ile Met Glu 
        35                  40                  45              


Ile Leu Glu Glu Lys Asp Gly Val Asp Thr Glu Leu Leu Val Tyr Ala 
    50                  55                  60                  


Met Thr Leu Val Asn Lys Thr Leu Ser Gly Leu Pro Asp Gln Asp Thr 
65                  70                  75                  80  


Phe Tyr Asp Val Val Asp Cys Leu Glu Glu Leu Gly Ile Ala Ala Val 
                85                  90                  95      


Ser Gln Arg His Leu Asn Lys Lys Gly Thr Asp Leu Asp Leu Val Glu 
            100                 105                 110         


Gln Leu Asn Ile Tyr Glu Val Ala Leu Arg His Glu Asp Gly Asp Glu 
        115                 120                 125             


Thr Thr Glu Pro Pro Pro Ser Gly Cys Arg Asp Arg Arg Arg Ala Ser 
    130                 135                 140                 


Val Cys Ser Ser Gly Gly Gly Glu His Arg Gly Leu Asp Arg Arg Arg 
145                 150                 155                 160 


Ser Arg Arg His Ser Val Gln Ser Ile Lys Ser Thr Leu Ser Ala Pro 
                165                 170                 175     


Thr Ser Pro Cys Ser Gln Ser Ala Pro Ser Phe Lys Pro Asn Gln Val 
            180                 185                 190         


Arg Asp Leu Arg Glu Lys Ser Ser Pro Ser Gly Leu Leu Thr Ser Ser 
        195                 200                 205             


Phe Arg Gln His Gln Glu Ser Leu Ala Ala Glu Arg Glu Arg Arg Arg 
    210                 215                 220                 


Gln Glu Arg Glu Glu Arg Leu Gln Arg Ile Glu Arg Glu Glu Arg Asn 
225                 230                 235                 240 


Lys Phe Ser Arg Asp Tyr Leu Asp Lys Arg Glu Glu Gln Arg Gln Ala 
                245                 250                 255     


Arg Glu Glu Arg Tyr Lys Tyr Leu Glu Gln Leu Ala Ala Glu Glu His 
            260                 265                 270         


Glu Lys Glu Leu Arg Ser Arg Ser Val Ser Arg Gly Arg Ala Asp Leu 
        275                 280                 285             


Ser Leu Asp Leu Thr Ser Pro Ala Ala Pro Ala Cys Leu Ala Pro Leu 
    290                 295                 300                 


Ser His Ser Pro Ser Ser Ser Asp Ser Gln Glu Ala Leu Thr Val Ser 
305                 310                 315                 320 


Ala Ser Ser Pro Gly Thr Pro His His Pro Gln Ala Ser Ala Gly Asp 
                325                 330                 335     


Pro Glu Pro Glu Ser Glu Ala Glu Pro Glu Ala Glu Ala Gly Ala Gly 
            340                 345                 350         


Gln Val Ala Asp Glu Ala Gly Gln Asp Ile Ala Ser Ala His Glu Gly 
        355                 360                 365             


Ala Glu Thr Glu Val Glu Gln Ala Leu Glu Gln Glu Pro Glu Glu Arg 
    370                 375                 380                 


Ala Ser Leu Ser Glu Lys Glu Arg Gln Asn Glu Gly Val Asn Glu Arg 
385                 390                 395                 400 


Asp Asn Cys Ser Ala Ser Ser Val Ser Ser Ser Ser Ser Thr Leu Glu 
                405                 410                 415     


Arg Glu Glu Lys Glu Asp Lys Leu Ser Arg Asp Arg Thr Thr Gly Leu 
            420                 425                 430         


Trp Pro Ala Gly Val Gln Asp Ala Gly Val Asn Gly Gln Cys Gly Asp 
        435                 440                 445             


Ile Leu Thr Asn Lys Arg Phe Met Leu Asp Met Leu Tyr Ala His Asn 
    450                 455                 460                 


Arg Lys Ser Pro Asp Asp Glu Glu Lys Gly Asp Gly Glu Ala Gly Arg 
465                 470                 475                 480 


Thr Gln Gln Glu Ala Glu Ala Val Ala Ser Leu Ala Thr Arg Ile Ser 
                485                 490                 495     


Thr Leu Gln Ala Asn Ser Gln Thr Gln Asp Glu Ser Val Arg Arg Val 
            500                 505                 510         


Asp Val Gly Cys Leu Asp Asn Arg Gly Ser Val Lys Ala Phe Ala Glu 
        515                 520                 525             


Lys Phe Asn Ser Gly Asp Leu Gly Arg Gly Ser Ile Ser Pro Asp Ala 
    530                 535                 540                 


Glu Pro Asn Asp Lys Val Pro Glu Thr Ala Pro Val Gln Pro Lys Thr 
545                 550                 555                 560 


Glu Ser Asp Tyr Ile Trp Asp Gln Leu Met Ala Asn Pro Arg Glu Leu 
                565                 570                 575     


Arg Ile Gln Asp Met Asp Phe Thr Asp Leu Gly Glu Glu Asp Asp Ile 
            580                 585                 590         


Asp Val Leu Asp Val Asp Leu Gly His Arg Glu Ala Pro Gly Pro Pro 
        595                 600                 605             


Pro Pro Pro Pro Pro Thr Phe Leu Gly Leu Pro Pro Pro Pro Pro Pro 
    610                 615                 620                 


Pro Leu Leu Asp Ser Ile Pro Pro Pro Pro Val Pro Gly Asn Leu Leu 
625                 630                 635                 640 


Val Pro Pro Pro Pro Val Phe Asn Ala Pro Gln Gly Leu Gly Trp Ser 
                645                 650                 655     


Gln Val Pro Arg Gly Gln Pro Thr Phe Thr Lys Lys Lys Lys Thr Ile 
            660                 665                 670         


Arg Leu Phe Trp Asn Glu Val Arg Pro Phe Asp Trp Pro Cys Lys Asn 
        675                 680                 685             


Asn Arg Arg Cys Arg Glu Phe Leu Trp Ser Lys Leu Glu Pro Ile Lys 
    690                 695                 700                 


Val Asp Thr Ser Arg Leu Glu His Leu Phe Glu Ser Lys Ser Lys Glu 
705                 710                 715                 720 


Leu Ser Val Ser Lys Lys Thr Ala Ala Asp Gly Lys Arg Gln Glu Ile 
                725                 730                 735     


Ile Val Leu Asp Ser Lys Arg Ser Asn Ala Ile Asn Ile Gly Leu Thr 
            740                 745                 750         


Val Leu Pro Pro Pro Arg Thr Ile Lys Ile Ala Ile Leu Asn Phe Asp 
        755                 760                 765             


Glu Tyr Ala Leu Asn Lys Glu Gly Ile Glu Lys Ile Leu Thr Met Ile 
    770                 775                 780                 


Pro Thr Asp Glu Glu Lys Gln Lys Ile Gln Glu Ala Gln Leu Ala Asn 
785                 790                 795                 800 


Pro Glu Ile Pro Leu Gly Ser Ala Glu Gln Phe Leu Leu Thr Leu Ser 
                805                 810                 815     


Ser Ile Ser Glu Leu Ser Ala Arg Leu His Leu Trp Ala Phe Lys Met 
            820                 825                 830         


Asp Tyr Glu Thr Thr Glu Lys Glu Val Ala Glu Pro Leu Leu Asp Leu 
        835                 840                 845             


Lys Glu Gly Ile Asp Gln Leu Glu Asn Asn Lys Thr Leu Gly Phe Ile 
    850                 855                 860                 


Leu Ser Thr Leu Leu Ala Ile Gly Asn Phe Leu Asn Gly Thr Asn Ala 
865                 870                 875                 880 


Lys Ala Phe Glu Leu Ser Tyr Leu Glu Lys Val Pro Glu Val Lys Asp 
                885                 890                 895     


Thr Val His Lys Gln Ser Leu Leu His His Val Cys Thr Met Val Val 
            900                 905                 910         


Glu Asn Phe Pro Asp Ser Ser Asp Leu Tyr Ser Glu Ile Gly Ala Ile 
        915                 920                 925             


Thr Arg Ser Ala Lys Val Asp Phe Asp Gln Leu Gln Asp Asn Leu Cys 
    930                 935                 940                 


Gln Met Glu Arg Arg Cys Lys Ala Ser Trp Asp His Leu Lys Ala Ile 
945                 950                 955                 960 


Ala Lys His Glu Met Lys Pro Val Leu Lys Gln Arg Met Ser Glu Phe 
                965                 970                 975     


Leu Lys Asp Cys Ala Glu Arg Ile Ile Ile Leu Lys Ile Val His Arg 
            980                 985                 990         


Arg Ile Ile Asn Arg Phe His Ser  Phe Leu Leu Phe Met  Gly His Pro 
        995                 1000                 1005             


Pro Tyr  Ala Ile Arg Glu Val  Asn Ile Asn Lys Phe  Cys Arg Ile 
    1010                 1015                 1020             


Ile Ser  Glu Phe Ala Leu Glu  Tyr Arg Thr Thr Arg  Glu Arg Val 
    1025                 1030                 1035             


Leu Gln  Gln Lys Gln Lys Arg  Ala Asn His Arg Glu  Arg Asn Lys 
    1040                 1045                 1050             


Thr Arg  Gly Lys Met Ile Thr  Asp Ser Gly Lys Phe  Ser Gly Ser 
    1055                 1060                 1065             


Ser Pro  Ala Pro Pro Ser Gln  Pro Gln Gly Leu Ser  Tyr Ala Glu 
    1070                 1075                 1080             


Asp Ala  Ala Glu His Glu Asn  Met Lys Ala Val Leu  Lys Thr Ser 
    1085                 1090                 1095             


Ser Pro  Ser Val Glu Asp Ala  Thr Pro Ala Leu Gly  Val Arg Thr 
    1100                 1105                 1110             


Arg Ser  Arg Ala Ser Arg Gly  Ser Thr Ser Ser Trp  Thr Met Gly 
    1115                 1120                 1125             


Thr Asp  Asp Ser Pro Asn Val  Thr Asp Asp Ala Ala  Asp Glu Ile 
    1130                 1135                 1140             


Met Asp  Arg Ile Val Lys Ser  Ala Thr Gln Val Pro  Ser Gln Arg 
    1145                 1150                 1155             


Val Val  Pro Arg Glu Arg Lys  Arg Ser Arg Ala Asn  Arg Lys Ser 
    1160                 1165                 1170             


Leu Arg  Arg Thr Leu Lys Ser  Gly Leu Thr Pro Glu  Glu Ala Arg 
    1175                 1180                 1185             


Ala Leu  Gly Leu Val Gly Thr  Ser Glu Leu Gln Leu  
    1190                 1195                 1200 


<210>  5419
<211>  211
<212>  PRT
<213>  Homo Sapiens

<400>  5419

Met Val Phe Leu Lys Phe Phe Cys Met Ser Phe Phe Cys His Leu Cys 
1               5                   10                  15      


Gln Gly Tyr Phe Asp Gly Pro Leu Tyr Pro Glu Met Ser Asn Gly Thr 
            20                  25                  30          


Leu His His Tyr Phe Val Pro Asp Gly Asp Tyr Glu Glu Asn Asp Asp 
        35                  40                  45              


Pro Glu Lys Cys Gln Leu Leu Phe Arg Val Ser Asp His Arg Arg Cys 
    50                  55                  60                  


Ser Gln Gly Glu Gly Ser Gln Val Gly Ser Leu Leu Ser Leu Thr Leu 
65                  70                  75                  80  


Arg Glu Glu Phe Thr Val Leu Gly Arg Gln Val Glu Asp Ala Gly Arg 
                85                  90                  95      


Val Leu Glu Gly Ile Ser Lys Ser Ile Ser Tyr Asp Leu Asp Gly Glu 
            100                 105                 110         


Glu Ser Tyr Gly Lys Tyr Leu Arg Arg Glu Ser His Gln Ile Gly Asp 
        115                 120                 125             


Ala Tyr Ser Asn Ser Asp Lys Ser Leu Thr Glu Leu Glu Ser Lys Phe 
    130                 135                 140                 


Lys Gln Gly Gln Glu Gln Asp Ser Arg Gln Glu Ser Arg Leu Asn Glu 
145                 150                 155                 160 


Asp Phe Leu Gly Met Leu Val His Thr Arg Ser Leu Leu Lys Glu Thr 
                165                 170                 175     


Leu Asp Ile Ser Val Gly Leu Arg Asp Lys Tyr Glu Leu Leu Ala Leu 
            180                 185                 190         


Thr Ile Arg Ser His Gly Thr Arg Leu Gly Arg Leu Lys Asn Asp Tyr 
        195                 200                 205             


Leu Lys Val 
    210     


<210>  5420
<211>  458
<212>  PRT
<213>  Homo Sapiens

<400>  5420

Met Met Leu Ile Pro Met Ala Ser Val Met Ala Val Thr Glu Pro Lys 
1               5                   10                  15      


Trp Val Ser Val Trp Ser Arg Phe Leu Trp Val Thr Leu Leu Ser Met 
            20                  25                  30          


Val Leu Gly Ser Leu Leu Ala Leu Leu Leu Pro Leu Gly Ala Val Glu 
        35                  40                  45              


Glu Gln Cys Leu Ala Val Leu Lys Gly Leu Tyr Leu Leu Arg Ser Lys 
    50                  55                  60                  


Pro Asp Arg Ala Gln His Ala Ala Thr Lys Cys Thr Ser Pro Ser Thr 
65                  70                  75                  80  


Glu Leu Ser Ile Thr Ser Arg Gly Ala Thr Leu Leu Val Ala Lys Thr 
                85                  90                  95      


Lys Ala Ser Pro Ala Gly Lys Leu Glu Ala Arg Ala Ala Leu Asn Gln 
            100                 105                 110         


Ala Leu Glu Met Lys Arg Gln Gly Lys Arg Glu Lys Ala Gln Lys Leu 
        115                 120                 125             


Phe Met His Ala Leu Lys Met Asp Pro Asp Phe Val Asp Ala Leu Thr 
    130                 135                 140                 


Glu Phe Gly Ile Phe Ser Glu Glu Asp Lys Asp Ile Ile Gln Ala Asp 
145                 150                 155                 160 


Tyr Leu Tyr Thr Arg Ala Leu Thr Ile Ser Pro Tyr His Glu Lys Ala 
                165                 170                 175     


Leu Val Asn Arg Asp Arg Thr Leu Pro Leu Val Glu Glu Ile Asp Gln 
            180                 185                 190         


Arg Tyr Phe Ser Ile Ile Asp Ser Lys Val Lys Lys Val Met Ser Ile 
        195                 200                 205             


Pro Lys Gly Asn Ser Ala Leu Arg Arg Val Met Glu Glu Thr Tyr Tyr 
    210                 215                 220                 


His His Ile Tyr His Thr Val Ala Ile Glu Gly Asn Thr Leu Thr Leu 
225                 230                 235                 240 


Ser Glu Ile Arg His Ile Leu Glu Thr Arg Tyr Ala Val Pro Gly Lys 
                245                 250                 255     


Ser Leu Glu Glu Gln Asn Glu Val Ile Gly Met His Ala Ala Met Lys 
            260                 265                 270         


Tyr Ile Asn Thr Thr Leu Val Ser Arg Ile Gly Ser Val Thr Ile Ser 
        275                 280                 285             


Asp Val Leu Glu Ile His Arg Arg Val Leu Gly Tyr Val Asp Pro Val 
    290                 295                 300                 


Glu Ala Gly Arg Phe Arg Thr Thr Gln Val Leu Val Gly His His Ile 
305                 310                 315                 320 


Pro Pro His Pro Gln Asp Val Glu Lys Gln Met Gln Glu Phe Val Gln 
                325                 330                 335     


Trp Leu Asn Ser Glu Glu Ala Met Asn Leu His Pro Val Glu Phe Ala 
            340                 345                 350         


Ala Leu Ala His Tyr Lys Leu Val Tyr Ile His Pro Phe Ile Asp Gly 
        355                 360                 365             


Asn Gly Arg Thr Ser Arg Leu Leu Met Asn Leu Ile Leu Met Gln Ala 
    370                 375                 380                 


Gly Tyr Pro Pro Ile Thr Ile Arg Lys Glu Gln Arg Ser Asp Tyr Tyr 
385                 390                 395                 400 


His Val Leu Glu Ala Ala Asn Glu Gly Asp Val Arg Pro Phe Ile Arg 
                405                 410                 415     


Phe Ile Ala Lys Cys Thr Glu Thr Thr Leu Asp Thr Leu Leu Phe Ala 
            420                 425                 430         


Thr Thr Glu Tyr Ser Val Ala Leu Pro Glu Ala Gln Pro Asn His Ser 
        435                 440                 445             


Gly Phe Lys Glu Thr Leu Pro Val Lys Pro 
    450                 455             


<210>  5421
<211>  180
<212>  PRT
<213>  Homo Sapiens

<400>  5421

Met Met Leu Ile Pro Met Ala Ser Val Met Ala Val Thr Glu Pro Lys 
1               5                   10                  15      


Trp Val Ser Val Trp Ser Arg Phe Leu Trp Val Thr Leu Leu Ser Met 
            20                  25                  30          


Val Leu Gly Ser Leu Leu Ala Leu Leu Leu Pro Leu Gly Ala Val Glu 
        35                  40                  45              


Glu Gln Cys Leu Ala Val Leu Lys Gly Leu Tyr Leu Leu Arg Ser Lys 
    50                  55                  60                  


Pro Asp Arg Ala Gln His Ala Ala Thr Lys Cys Thr Ser Pro Ser Thr 
65                  70                  75                  80  


Glu Leu Ser Ile Thr Ser Arg Gly Ala Thr Leu Leu Val Ala Lys Thr 
                85                  90                  95      


Lys Ala Ser Pro Glu Ser Arg Arg Leu Gly Ser Gln Gly Gly Ala Ser 
            100                 105                 110         


Gln Asn Thr Arg Glu Trp Leu Trp Gly His Thr Asp Ser Asp Cys Ile 
        115                 120                 125             


Pro Pro His Gly Trp Gly Asn Arg Val Val Pro Gly Met Leu Ser Thr 
    130                 135                 140                 


His Asp Ala Ala Ala Thr Ser Ser Ser Arg Pro Gly Thr Gln Ala Gly 
145                 150                 155                 160 


His His Gly Phe Leu Arg Arg Pro Ala Gln Gly Thr Ala Pro Arg Met 
                165                 170                 175     


Ser Ser Ala Pro 
            180 


<210>  5422
<211>  139
<212>  PRT
<213>  Homo Sapiens

<400>  5422

Met Met Leu Ile Pro Met Ala Ser Val Met Ala Val Thr Glu Pro Lys 
1               5                   10                  15      


Trp Val Ser Val Trp Ser Arg Phe Leu Trp Val Thr Leu Leu Ser Met 
            20                  25                  30          


Val Leu Gly Ser Leu Leu Ala Leu Leu Leu Pro Leu Gly Ala Val Glu 
        35                  40                  45              


Glu Gln Cys Leu Ala Val Leu Lys Gly Leu Tyr Leu Leu Arg Ser Lys 
    50                  55                  60                  


Pro Asp Arg Ala Gln His Ala Ala Thr Lys Cys Thr Ser Pro Ser Thr 
65                  70                  75                  80  


Glu Leu Ser Ile Thr Ser Arg Gly Ala Thr Leu Leu Val Ala Lys Thr 
                85                  90                  95      


Lys Ala Ser Pro Gly Lys Thr Asp Trp Pro Ser Ser Ser Met Leu Val 
            100                 105                 110         


Asn Trp Ile Asp Arg His Arg Met Cys His Val Leu Tyr Val Gly His 
        115                 120                 125             


Arg Gly Ile Val Asn Lys Ser Ala Leu Ser Ser 
    130                 135                 


<210>  5423
<211>  56
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5423

Xaa Cys Leu Ala Val Leu Lys Gly Leu Tyr Leu Leu Arg Ser Lys Pro 
1               5                   10                  15      


Asp Arg Ala Gln His Ala Ala Thr Lys Cys Thr Ser Pro Ser Thr Glu 
            20                  25                  30          


Leu Ser Ile Thr Ser Arg Gly Ala Thr Leu Leu Val Ala Lys Thr Lys 
        35                  40                  45              


Ala Ser Pro Gly Lys Cys Cys Thr 
    50                  55      


<210>  5424
<211>  437
<212>  PRT
<213>  Homo Sapiens

<400>  5424

Met Gly Arg Arg Met Arg Gly Ala Ala Ala Thr Ala Gly Leu Trp Leu 
1               5                   10                  15      


Leu Ala Leu Gly Ser Leu Leu Ala Leu Trp Gly Gly Leu Leu Pro Pro 
            20                  25                  30          


Arg Thr Glu Leu Pro Ala Ser Arg Pro Pro Glu Asp Arg Leu Pro Arg 
        35                  40                  45              


Arg Pro Ala Arg Ser Gly Gly Pro Ala Pro Ala Pro Arg Phe Pro Leu 
    50                  55                  60                  


Pro Pro Pro Leu Ala Trp Asp Ala Arg Gly Gly Ser Leu Lys Thr Phe 
65                  70                  75                  80  


Arg Ala Leu Leu Thr Leu Ala Ala Gly Ala Asp Gly Pro Pro Arg Gln 
                85                  90                  95      


Ser Arg Ser Glu Pro Arg Trp His Val Ser Ala Arg Gln Pro Arg Pro 
            100                 105                 110         


Glu Glu Ser Ala Ala Val His Gly Gly Val Phe Trp Ser Arg Gly Leu 
        115                 120                 125             


Glu Glu Gln Val Pro Pro Gly Phe Ser Glu Ala Gln Ala Ala Ala Trp 
    130                 135                 140                 


Leu Glu Ala Ala Arg Gly Ala Arg Met Val Ala Leu Glu Arg Gly Gly 
145                 150                 155                 160 


Cys Gly Arg Ser Ser Asn Arg Leu Ala Arg Phe Ala Asp Gly Thr Arg 
                165                 170                 175     


Ala Cys Val Arg Tyr Gly Ile Asn Pro Glu Gln Ile Gln Gly Glu Ala 
            180                 185                 190         


Leu Ser Tyr Tyr Leu Ala Arg Leu Leu Gly Leu Gln Arg His Val Pro 
        195                 200                 205             


Pro Leu Ala Leu Ala Arg Val Glu Ala Arg Gly Ala Gln Trp Ala Gln 
    210                 215                 220                 


Val Gln Glu Glu Leu Arg Ala Ala His Trp Thr Glu Gly Ser Val Val 
225                 230                 235                 240 


Ser Leu Thr Arg Trp Leu Pro Asn Leu Thr Asp Val Val Val Pro Ala 
                245                 250                 255     


Pro Trp Arg Ser Glu Asp Gly Arg Leu Arg Pro Leu Arg Asp Ala Gly 
            260                 265                 270         


Gly Glu Leu Ala Asn Leu Ser Gln Ala Glu Leu Val Asp Leu Val Gln 
        275                 280                 285             


Trp Thr Asp Leu Ile Leu Phe Asp Tyr Leu Thr Ala Asn Phe Asp Arg 
    290                 295                 300                 


Leu Val Ser Asn Leu Phe Ser Leu Gln Trp Asp Pro Arg Val Met Gln 
305                 310                 315                 320 


Arg Ala Thr Ser Asn Leu His Arg Gly Pro Gly Gly Ala Leu Val Phe 
                325                 330                 335     


Leu Asp Asn Glu Ala Gly Leu Val His Gly Tyr Arg Val Ala Gly Met 
            340                 345                 350         


Trp Asp Lys Tyr Asn Glu Pro Leu Leu Gln Ser Val Cys Val Phe Arg 
        355                 360                 365             


Glu Arg Thr Ala Arg Arg Val Leu Glu Leu His Arg Gly Gln Asp Ala 
    370                 375                 380                 


Ala Ala Arg Leu Leu Arg Leu Tyr Arg Arg His Glu Pro Arg Phe Pro 
385                 390                 395                 400 


Glu Leu Ala Ala Leu Ala Asp Pro His Ala Gln Leu Leu Gln Arg Arg 
                405                 410                 415     


Leu Asp Phe Leu Ala Lys His Ile Leu His Cys Lys Ala Lys Tyr Gly 
            420                 425                 430         


Arg Arg Ser Gly Thr 
        435         


<210>  5425
<211>  147
<212>  PRT
<213>  Homo Sapiens

<400>  5425

Met Phe Pro Ala Gly Pro Pro Ser His Ser Leu Leu Arg Leu Pro Leu 
1               5                   10                  15      


Leu Gln Leu Leu Leu Leu Val Val Gln Ala Val Gly Arg Gly Leu Gly 
            20                  25                  30          


Arg Ala Ser Pro Ala Gly Gly Pro Leu Glu Asp Val Val Ile Glu Arg 
        35                  40                  45              


Tyr His Ile Pro Arg Ala Cys Pro Arg Glu Val Gln Met Gly Asp Phe 
    50                  55                  60                  


Val Arg Tyr His Tyr Asn Gly Thr Phe Glu Asp Gly Lys Lys Phe Asp 
65                  70                  75                  80  


Ser Ser Gly Ala His Ser Thr Gly Cys His Pro Leu Leu Arg Cys Gly 
                85                  90                  95      


Ser Ala Gly Cys Val Glu Gln Gly Arg His Arg Ala Gly Glu His Ile 
            100                 105                 110         


Ala Ala Pro Ala Pro Leu Pro Pro His Gly Pro Gly Arg Arg Leu Cys 
        115                 120                 125             


Pro Leu Pro Leu Gln Trp His Pro Ala Gly Arg His Leu Leu Arg His 
    130                 135                 140                 


Gln Leu Gln 
145         


<210>  5426
<211>  171
<212>  PRT
<213>  Homo Sapiens

<400>  5426

Met Phe Pro Ala Gly Pro Pro Ser His Ser Leu Leu Arg Leu Pro Leu 
1               5                   10                  15      


Leu Gln Leu Leu Leu Leu Val Val Gln Ala Val Gly Arg Gly Leu Gly 
            20                  25                  30          


Arg Ala Ser Pro Ala Gly Gly Pro Leu Glu Asp Val Val Ile Glu Arg 
        35                  40                  45              


Tyr His Ile Pro Arg Ala Cys Pro Arg Glu Val Gln Met Gly Asp Phe 
    50                  55                  60                  


Val Arg Tyr His Tyr Asn Gly Thr Phe Glu Asp Gly Lys Lys Phe Asp 
65                  70                  75                  80  


Ser Ser Tyr Asp Arg Asn Thr Leu Val Ala Ile Val Val Gly Val Gly 
                85                  90                  95      


Arg Leu Ile Thr Gly Met Asp Arg Gly Leu Met Gly Met Cys Val Asn 
            100                 105                 110         


Glu Arg Arg Arg Leu Ile Val Pro Pro His Leu Gly Tyr Gly Ser Ile 
        115                 120                 125             


Gly Leu Ala Gly Leu Ile Pro Pro Asp Ala Thr Leu Tyr Phe Asp Val 
    130                 135                 140                 


Val Leu Leu Asp Val Trp Asn Lys Glu Asp Thr Val Gln Val Ser Thr 
145                 150                 155                 160 


Leu Leu Arg Pro Pro His Cys Pro Arg Met Val 
                165                 170     


<210>  5427
<211>  582
<212>  PRT
<213>  Homo Sapiens

<400>  5427

Met Phe Pro Ala Gly Pro Pro Ser His Ser Leu Leu Arg Leu Pro Leu 
1               5                   10                  15      


Leu Gln Leu Leu Leu Leu Val Val Gln Ala Val Gly Arg Gly Leu Gly 
            20                  25                  30          


Arg Ala Ser Pro Ala Gly Gly Pro Leu Glu Asp Val Val Ile Glu Arg 
        35                  40                  45              


Tyr His Ile Pro Arg Ala Cys Pro Arg Glu Val Gln Met Gly Asp Phe 
    50                  55                  60                  


Val Arg Tyr His Tyr Asn Gly Thr Phe Glu Asp Gly Lys Lys Phe Asp 
65                  70                  75                  80  


Ser Ser Tyr Asp Arg Asn Thr Leu Val Ala Ile Val Val Gly Val Gly 
                85                  90                  95      


Arg Leu Ile Thr Gly Met Asp Arg Gly Leu Met Gly Met Cys Val Asn 
            100                 105                 110         


Glu Arg Arg Arg Leu Ile Val Pro Pro His Leu Gly Tyr Gly Ser Ile 
        115                 120                 125             


Gly Leu Ala Gly Leu Ile Pro Pro Asp Ala Thr Leu Tyr Phe Asp Val 
    130                 135                 140                 


Val Leu Leu Asp Val Trp Asn Lys Glu Asp Thr Val Gln Val Ser Thr 
145                 150                 155                 160 


Leu Leu Arg Pro Pro His Cys Pro Arg Met Val Gln Asp Gly Asp Phe 
                165                 170                 175     


Val Arg Tyr His Tyr Asn Gly Thr Leu Leu Asp Gly Thr Ser Phe Asp 
            180                 185                 190         


Thr Ser Tyr Ser Lys Gly Gly Thr Tyr Asp Thr Tyr Val Gly Ser Gly 
        195                 200                 205             


Trp Leu Ile Lys Gly Met Asp Gln Gly Leu Leu Gly Met Cys Pro Gly 
    210                 215                 220                 


Glu Arg Arg Lys Ile Ile Ile Pro Pro Phe Leu Ala Tyr Gly Glu Lys 
225                 230                 235                 240 


Gly Tyr Gly Thr Val Ile Pro Pro Gln Ala Ser Leu Val Phe His Val 
                245                 250                 255     


Leu Leu Ile Asp Val His Asn Pro Lys Asp Ala Val Gln Leu Glu Thr 
            260                 265                 270         


Leu Glu Leu Pro Pro Gly Cys Val Arg Arg Ala Gly Ala Gly Asp Phe 
        275                 280                 285             


Met Arg Tyr His Tyr Asn Gly Ser Leu Met Asp Gly Thr Leu Phe Asp 
    290                 295                 300                 


Ser Ser Tyr Ser Arg Asn His Thr Tyr Asn Thr Tyr Ile Gly Gln Gly 
305                 310                 315                 320 


Tyr Ile Ile Pro Gly Met Asp Gln Gly Leu Gln Gly Ala Cys Met Gly 
                325                 330                 335     


Glu Arg Arg Arg Ile Thr Ile Pro Pro His Leu Ala Tyr Gly Glu Asn 
            340                 345                 350         


Gly Thr Gly Asp Lys Ile Pro Gly Ser Ala Val Leu Ile Phe Asn Val 
        355                 360                 365             


His Val Ile Asp Phe His Asn Pro Ala Asp Val Val Glu Ile Arg Thr 
    370                 375                 380                 


Leu Ser Arg Pro Ser Glu Thr Cys Asn Glu Thr Thr Lys Leu Gly Asp 
385                 390                 395                 400 


Phe Val Arg Tyr His Tyr Asn Cys Ser Leu Leu Asp Gly Thr Gln Leu 
                405                 410                 415     


Phe Thr Ser His Asp Tyr Gly Ala Pro Gln Glu Ala Thr Leu Gly Ala 
            420                 425                 430         


Asn Lys Val Ile Glu Gly Leu Asp Thr Gly Leu Gln Gly Met Cys Val 
        435                 440                 445             


Gly Glu Arg Arg Gln Leu Ile Val Pro Pro His Leu Ala His Gly Glu 
    450                 455                 460                 


Ser Gly Ala Arg Gly Val Pro Gly Ser Ala Val Leu Leu Phe Glu Val 
465                 470                 475                 480 


Glu Leu Val Ser Arg Glu Asp Gly Leu Pro Thr Gly Tyr Leu Phe Val 
                485                 490                 495     


Trp His Lys Asp Pro Pro Ala Asn Leu Phe Glu Asp Met Asp Leu Asn 
            500                 505                 510         


Lys Asp Gly Glu Val Pro Pro Glu Glu Phe Ser Thr Phe Ile Lys Ala 
        515                 520                 525             


Gln Val Ser Glu Gly Lys Gly Arg Leu Met Pro Gly Gln Asp Pro Glu 
    530                 535                 540                 


Lys Thr Ile Gly Asp Met Phe Gln Asn Gln Asp Arg Asn Gln Asp Gly 
545                 550                 555                 560 


Lys Ile Thr Val Asp Glu Leu Lys Leu Lys Ser Asp Glu Asp Glu Glu 
                565                 570                 575     


Arg Val His Glu Glu Leu 
            580         


<210>  5428
<211>  81
<212>  PRT
<213>  Homo Sapiens

<400>  5428

Met Gly Asp Phe Val Arg Tyr His Tyr Asn Gly Thr Phe Glu Asp Gly 
1               5                   10                  15      


Lys Lys Phe Asp Ser Ser Tyr Asp Arg Asn Thr Leu Val Ala Ile Val 
            20                  25                  30          


Val Gly Val Gly Arg Leu Ile Thr Gly Met Asp Arg Gly Leu Met Gly 
        35                  40                  45              


Met Cys Val Asn Glu Arg Arg Arg Leu Ile Val Pro Pro His Leu Gly 
    50                  55                  60                  


Tyr Gly Ser Ile Gly Leu Ala Gly Leu Ile Pro Pro Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr 
    


<210>  5429
<211>  172
<212>  PRT
<213>  Homo Sapiens

<400>  5429

Met Gly Asp Phe Val Arg Tyr His Tyr Asn Gly Thr Phe Glu Asp Gly 
1               5                   10                  15      


Lys Lys Phe Asp Ser Ser Tyr Asp Arg Asn Thr Leu Val Ala Ile Val 
            20                  25                  30          


Val Gly Val Gly Arg Leu Ile Thr Gly Met Asp Arg Gly Leu Met Gly 
        35                  40                  45              


Met Cys Val Asn Glu Arg Arg Arg Leu Ile Val Pro Pro His Leu Gly 
    50                  55                  60                  


Tyr Gly Ser Ile Gly Leu Ala Gly Leu Ile Pro Pro Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Phe Asp Val Val Leu Leu Asp Val Trp Asn Lys Glu Asp Thr Val 
                85                  90                  95      


Gln Val Ser Thr Leu Leu Arg Pro Pro His Cys Pro Arg Met Val Gln 
            100                 105                 110         


Asp Gly Asp Phe Val Arg Tyr His Tyr Asn Gly Thr Leu Leu Asp Gly 
        115                 120                 125             


Thr Ser Phe Asp Thr Ser Tyr Ser Lys Gly Gly Thr Tyr Asp Thr Tyr 
    130                 135                 140                 


Val Gly Ser Gly Trp Leu Ile Lys Gly Met Asp Gln Gly Leu Leu Gly 
145                 150                 155                 160 


Met Cys Pro Gly Glu Arg Arg Lys Ile Ile Ile Pro 
                165                 170         


<210>  5430
<211>  386
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5430

Xaa Ile Asp Val His Asn Pro Lys Asp Ala Val Gln Leu Glu Thr Leu 
1               5                   10                  15      


Glu Leu Pro Pro Gly Cys Val Arg Arg Ala Gly Ala Gly Asp Phe Met 
            20                  25                  30          


Arg Tyr His Tyr Asn Gly Ser Leu Met Asp Gly Thr Leu Phe Asp Ser 
        35                  40                  45              


Ser Tyr Ser Arg Asn His Thr Tyr Asn Thr Tyr Ile Gly Gln Gly Tyr 
    50                  55                  60                  


Ile Ile Pro Gly Met Asp Gln Gly Leu Gln Gly Ala Cys Met Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Ile Thr Ile Pro Pro His Leu Ala Tyr Gly Glu Asn Gly 
                85                  90                  95      


Thr Asp Ser Ile Gly Phe Leu Gln Gly Ser Ala Pro Leu Arg Pro Phe 
            100                 105                 110         


Arg Ser Gly Glu Gly Gln Pro Ser Leu Gly Arg Glu Gly Gly Tyr Gly 
        115                 120                 125             


Lys Thr Glu Pro Ala Tyr Pro Gln Asp Pro Ala Val Leu Gly Ala Ser 
    130                 135                 140                 


Val Ser Ser Pro Val Lys Trp Ala Ser His Ala Asp Pro Gln Gly Asp 
145                 150                 155                 160 


Lys Ile Pro Gly Ser Ala Val Leu Ile Phe Asn Val His Val Ile Asp 
                165                 170                 175     


Phe His Asn Pro Ala Asp Val Val Glu Ile Arg Thr Leu Ser Arg Pro 
            180                 185                 190         


Ser Glu Thr Cys Asn Glu Thr Thr Lys Leu Gly Asp Phe Val Arg Tyr 
        195                 200                 205             


His Tyr Asn Cys Ser Leu Leu Asp Gly Thr Gln Leu Phe Thr Ser His 
    210                 215                 220                 


Asp Tyr Gly Ala Pro Gln Glu Ala Thr Leu Gly Ala Asn Lys Val Ile 
225                 230                 235                 240 


Glu Gly Leu Asp Thr Gly Leu Gln Gly Met Cys Val Gly Glu Arg Arg 
                245                 250                 255     


Gln Leu Ile Val Pro Pro His Leu Ala His Gly Glu Ser Gly Ala Arg 
            260                 265                 270         


Gly Val Pro Gly Ser Ala Val Leu Leu Phe Glu Val Glu Leu Val Ser 
        275                 280                 285             


Arg Glu Asp Gly Leu Pro Thr Gly Tyr Leu Phe Val Trp His Lys Asp 
    290                 295                 300                 


Pro Pro Ala Asn Leu Phe Glu Asp Met Asp Leu Asn Lys Asp Gly Glu 
305                 310                 315                 320 


Val Pro Pro Glu Glu Phe Ser Thr Phe Ile Lys Ala Gln Val Ser Glu 
                325                 330                 335     


Gly Lys Gly Arg Leu Met Pro Gly Gln Asp Pro Glu Lys Thr Ile Gly 
            340                 345                 350         


Asp Met Phe Gln Asn Gln Asp Arg Asn Gln Asp Gly Lys Ile Thr Val 
        355                 360                 365             


Asp Glu Leu Lys Leu Lys Ser Asp Glu Asp Glu Glu Arg Val His Glu 
    370                 375                 380                 


Glu Leu 
385     


<210>  5431
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  5431

Met Cys Val Gly Glu Lys Arg Arg Ala Ile Ile Pro Ser His Leu Ala 
1               5                   10                  15      


Tyr Gly Lys Arg Gly Phe Pro Pro Ser Val Pro Ala Asp Ala Val Val 
            20                  25                  30          


Gln Tyr Asp Val Glu Leu Ile Ala Leu Ile Arg Ala Asn Tyr Trp Leu 
        35                  40                  45              


Lys Leu Val Lys Gly Ile Leu Pro Leu Val Gly Met Ala Met Val Pro 
    50                  55                  60                  


Ala Leu Leu Gly Leu Ile Gly Tyr His Leu Tyr Arg Lys Ala Asn Arg 
65                  70                  75                  80  


Pro Lys Val Ser Lys Lys Lys Leu Lys Glu Glu Lys Arg Asn Lys Ser 
                85                  90                  95      


Lys Lys Lys 
            


<210>  5432
<211>  92
<212>  PRT
<213>  Homo Sapiens

<400>  5432

Met Thr Leu Arg Pro Ser Leu Leu Pro Leu His Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ala Ala Val Cys Arg Ala Glu Ala Gly Leu Glu Thr Glu 
            20                  25                  30          


Ser Pro Val Arg Thr Leu Gln Val Glu Thr Leu Gly Arg Glu Arg Asp 
        35                  40                  45              


Leu Trp Lys Ser Ile Arg Asp Pro Cys Ser Pro Ile Val Gly Gly Ala 
    50                  55                  60                  


Pro Arg Thr Met Cys Arg Ala Arg Cys Phe Trp Arg His Ala Ser His 
65                  70                  75                  80  


Thr Leu His Gly Lys Leu Gly Arg Trp Thr Tyr Tyr 
                85                  90          


<210>  5433
<211>  72
<212>  PRT
<213>  Homo Sapiens

<400>  5433

Met Thr Leu Arg Pro Ser Leu Leu Pro Leu His Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ala Ala Val Cys Arg Ala Glu Ala Gly Leu Glu Thr Glu 
            20                  25                  30          


Ser Pro Val Arg Thr Leu Gln Val Glu Thr Leu Ser Asp Arg Arg Trp 
        35                  40                  45              


Ser Pro Gln Asn His Val Pro Ser Pro Leu Leu Leu Glu Thr Arg Phe 
    50                  55                  60                  


Thr Tyr Thr Thr Arg Glu Ala Trp 
65                  70          


<210>  5434
<211>  201
<212>  PRT
<213>  Homo Sapiens

<400>  5434

Met Thr Leu Arg Pro Ser Leu Leu Pro Leu His Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ala Ala Val Cys Arg Ala Glu Ala Gly Leu Glu Thr Glu 
            20                  25                  30          


Ser Pro Val Arg Thr Leu Gln Val Glu Thr Leu Val Glu Pro Pro Glu 
        35                  40                  45              


Pro Cys Ala Glu Pro Ala Ala Phe Gly Asp Thr Leu His Ile His Tyr 
    50                  55                  60                  


Thr Gly Ser Leu Val Asp Gly Arg Ile Ile Asp Thr Ser Leu Thr Arg 
65                  70                  75                  80  


Asp Pro Leu Val Ile Glu Leu Gly Gln Lys Gln Val Ile Pro Gly Leu 
                85                  90                  95      


Glu Gln Ser Leu Leu Asp Met Cys Val Gly Glu Lys Arg Arg Ala Ile 
            100                 105                 110         


Ile Pro Ser His Leu Ala Tyr Gly Lys Arg Gly Phe Pro Pro Ser Val 
        115                 120                 125             


Pro Ala Asp Ala Val Val Gln Tyr Asp Val Glu Leu Ile Ala Leu Ile 
    130                 135                 140                 


Arg Ala Asn Tyr Trp Leu Lys Leu Val Lys Gly Ile Leu Pro Leu Val 
145                 150                 155                 160 


Gly Met Ala Met Val Pro Ala Leu Leu Gly Leu Ile Gly Tyr His Leu 
                165                 170                 175     


Tyr Arg Lys Ala Asn Arg Pro Lys Val Ser Lys Lys Lys Leu Lys Glu 
            180                 185                 190         


Glu Lys Arg Asn Lys Ser Lys Lys Lys 
        195                 200     


<210>  5435
<211>  182
<212>  PRT
<213>  Homo Sapiens

<400>  5435

Met Thr Leu Arg Pro Ser Leu Leu Pro Leu His Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ala Ala Val Cys Arg Ala Glu Ala Gly Leu Glu Thr Glu 
            20                  25                  30          


Ser Pro Val Arg Thr Leu Gln Val Glu Thr Leu Val Glu Pro Pro Glu 
        35                  40                  45              


Pro Cys Ala Glu Pro Ala Ala Phe Gly Asp Thr Leu His Ile His Tyr 
    50                  55                  60                  


Thr Gly Ser Leu Val Asp Gly Arg Ile Ile Asp Thr Ser Leu Thr Arg 
65                  70                  75                  80  


Asp Pro Leu Val Ile Glu Leu Gly Gln Lys Gln Val Ile Pro Gly Leu 
                85                  90                  95      


Glu Gln Ser Leu Leu Asp Met Cys Val Gly Glu Lys Arg Arg Ala Ile 
            100                 105                 110         


Ile Pro Ser His Leu Ala Tyr Gly Lys Arg Gly Phe Pro Pro Ser Val 
        115                 120                 125             


Pro Asp Gly Val Ser Leu Leu Leu Pro Arg Leu Glu Cys Asn Ser Ala 
    130                 135                 140                 


Ile Phe Thr His His Asn Leu Arg His Pro Gly Ser Ser Asn Ser Pro 
145                 150                 155                 160 


Val Ser Ala Ser Arg Val Ala Gly Ile Thr Gly Met Arg His His Asp 
                165                 170                 175     


Arg Leu Ile Leu Tyr Phe 
            180         


<210>  5436
<211>  146
<212>  PRT
<213>  Homo Sapiens

<400>  5436

Met Thr Leu Arg Pro Ser Leu Leu Pro Leu His Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ala Ala Val Cys Arg Ala Glu Ala Gly Leu Glu Thr Glu 
            20                  25                  30          


Ser Pro Val Arg Thr Leu Gln Val Glu Thr Leu Val Glu Pro Pro Glu 
        35                  40                  45              


Pro Cys Ala Glu Pro Ala Ala Phe Gly Asp Thr Leu His Ile His Tyr 
    50                  55                  60                  


Thr Gly Ser Leu Val Asp Gly Arg Ile Ile Asp Thr Ser Leu Thr Arg 
65                  70                  75                  80  


Asp Pro Leu Val Ile Glu Leu Gly Gln Lys Gln Val Ile Pro Gly Leu 
                85                  90                  95      


Glu Gln Ser Leu Leu Asp Met Cys Val Gly Glu Lys Arg Arg Ala Ile 
            100                 105                 110         


Ile Pro Ser His Leu Ala Tyr Gly Lys Arg Gly Phe Pro Pro Ser Val 
        115                 120                 125             


Pro Gly Thr Lys Asp Asn Leu Met Arg Pro Pro Gly Met Thr Ser Ser 
    130                 135                 140                 


Ser Gln 
145     


<210>  5437
<211>  63
<212>  PRT
<213>  Homo Sapiens

<400>  5437

Ser Leu Thr Arg Asp Pro Leu Val Ile Glu Leu Gly Gln Lys Gln Val 
1               5                   10                  15      


Ile Pro Gly Leu Glu Gln Ser Leu Leu Asp Met Cys Val Gly Trp Lys 
            20                  25                  30          


Asn Ser Cys Phe Gly Cys Glu Asp Ser Gly Gly Phe Ala Glu Gly Ala 
        35                  40                  45              


Ser Ala Gly Leu Arg Leu Leu Ala Tyr Leu Ser Cys Leu Trp Leu 
    50                  55                  60              


<210>  5438
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  5438

Met Arg Leu Phe Leu Trp Asn Ala Val Leu Thr Leu Phe Val Thr Ser 
1               5                   10                  15      


Leu Ile Gly Ala Leu Ile Pro Glu Pro Glu Val Lys Ile Glu Val Leu 
            20                  25                  30          


Gln Lys Pro Phe Ile Cys His Arg Lys Thr Lys Gly Gly Asp Leu Met 
        35                  40                  45              


Leu Val His Tyr Glu Gly Tyr Leu Glu Lys Asp Gly Ser Leu Phe His 
    50                  55                  60                  


Ser Thr 
65      


<210>  5439
<211>  211
<212>  PRT
<213>  Homo Sapiens

<400>  5439

Met Arg Leu Phe Leu Trp Asn Ala Val Leu Thr Leu Phe Val Thr Ser 
1               5                   10                  15      


Leu Ile Gly Ala Leu Ile Pro Glu Pro Glu Val Lys Ile Glu Val Leu 
            20                  25                  30          


Gln Lys Pro Phe Ile Cys His Arg Lys Thr Lys Gly Gly Asp Leu Met 
        35                  40                  45              


Leu Val His Tyr Glu Gly Tyr Leu Glu Lys Asp Gly Ser Leu Phe His 
    50                  55                  60                  


Ser Thr His Lys His Asn Asn Gly Gln Pro Ile Trp Phe Thr Leu Gly 
65                  70                  75                  80  


Ile Leu Glu Ala Leu Lys Gly Trp Asp Gln Gly Leu Lys Gly Met Cys 
                85                  90                  95      


Val Gly Glu Lys Arg Lys Leu Ile Ile Pro Pro Ala Leu Gly Tyr Gly 
            100                 105                 110         


Lys Glu Gly Lys Gly Lys Ile Pro Pro Glu Ser Thr Leu Ile Phe Asn 
        115                 120                 125             


Ile Asp Leu Leu Glu Ile Arg Asn Gly Pro Arg Ser His Glu Ser Phe 
    130                 135                 140                 


Gln Glu Met Asp Leu Asn Asp Asp Trp Lys Leu Ser Lys Asp Glu Val 
145                 150                 155                 160 


Lys Ala Tyr Leu Lys Lys Glu Phe Glu Lys His Gly Ala Val Val Asn 
                165                 170                 175     


Glu Ser His His Asp Ala Leu Val Glu Asp Ile Phe Asp Lys Glu Asp 
            180                 185                 190         


Glu Asp Lys Asp Gly Phe Ile Ser Ala Arg Glu Phe Thr Tyr Lys His 
        195                 200                 205             


Asp Glu Leu 
    210     


<210>  5440
<211>  89
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5440

Xaa Val Leu Gln Lys Pro Phe Ile Cys His Arg Lys Thr Lys Gly Gly 
1               5                   10                  15      


Asp Leu Met Leu Val His Tyr Glu Gly Tyr Leu Glu Lys Asp Gly Ser 
            20                  25                  30          


Leu Phe His Ser Thr His Lys His Asn Asn Gly Gln Pro Ile Trp Phe 
        35                  40                  45              


Thr Leu Gly Ile Leu Glu Ala Leu Lys Gly Trp Asp Gln Gly Leu Lys 
    50                  55                  60                  


Gly Met Cys Val Gly Glu Lys Arg Lys Leu Ile Ile Pro Pro Ala Leu 
65                  70                  75                  80  


Gly Tyr Gly Lys Glu Gly Lys Val Phe 
                85                  


<210>  5441
<211>  102
<212>  PRT
<213>  Homo Sapiens

<400>  5441

Met Arg Leu Ser Trp Phe Arg Val Leu Thr Val Leu Ser Ile Cys Leu 
1               5                   10                  15      


Ser Ala Val Ala Thr Ala Thr Gly Ala Glu Gly Lys Arg Lys Leu Gln 
            20                  25                  30          


Ile Gly Val Lys Lys Arg Val Asp His Cys Pro Ile Lys Ser Arg Lys 
        35                  40                  45              


Gly Asp Val Leu His Met His Tyr Thr Gly Lys Leu Glu Asp Gly Thr 
    50                  55                  60                  


Glu Phe Asp Ser Ser Leu Pro Gln Asn Gln Pro Phe Val Phe Ser Leu 
65                  70                  75                  80  


Gly Thr Gly Gln Val Ile Lys Gly Trp Asp Gln Gly Leu Leu Gly Met 
                85                  90                  95      


Cys Glu Gly Glu Lys Arg 
            100         


<210>  5442
<211>  142
<212>  PRT
<213>  Homo Sapiens

<400>  5442

Met Arg Leu Ser Trp Phe Arg Val Leu Thr Val Leu Ser Ile Cys Leu 
1               5                   10                  15      


Ser Ala Val Ala Thr Ala Thr Gly Ala Glu Gly Lys Arg Lys Leu Gln 
            20                  25                  30          


Ile Gly Val Lys Lys Arg Val Asp His Cys Pro Ile Lys Ser Arg Lys 
        35                  40                  45              


Gly Asp Val Leu His Met His Tyr Thr Gly Lys Leu Glu Asp Gly Thr 
    50                  55                  60                  


Glu Phe Asp Ser Ser Leu Pro Gln Asn Gln Pro Phe Val Phe Ser Leu 
65                  70                  75                  80  


Gly Thr Gly Gln Val Ile Lys Gly Trp Asp Gln Gly Leu Leu Gly Met 
                85                  90                  95      


Cys Glu Gly Glu Lys Arg Lys Leu Val Ile Pro Ser Glu Leu Gly Tyr 
            100                 105                 110         


Gly Glu Arg Gly Ala Pro Pro Lys Ile Pro Gly Gly Ala Thr Leu Val 
        115                 120                 125             


Phe Glu Val Glu Leu Leu Lys Ile Glu Arg Arg Thr Glu Leu 
    130                 135                 140         


<210>  5443
<211>  142
<212>  PRT
<213>  Homo Sapiens

<400>  5443

Met Arg Leu Ser Trp Phe Arg Val Leu Thr Val Leu Ser Ile Cys Leu 
1               5                   10                  15      


Ser Ala Val Ala Thr Ala Thr Gly Ala Glu Gly Lys Arg Lys Leu Gln 
            20                  25                  30          


Ile Gly Val Lys Lys Arg Val Asp His Cys Pro Ile Lys Ser Arg Lys 
        35                  40                  45              


Gly Asp Val Leu His Met His Tyr Thr Gly Lys Leu Glu Asp Gly Thr 
    50                  55                  60                  


Glu Phe Asp Ser Ser Leu Pro Gln Asn Gln Pro Phe Val Phe Ser Leu 
65                  70                  75                  80  


Gly Thr Gly Gln Val Ile Lys Gly Trp Asp Gln Gly Leu Leu Gly Met 
                85                  90                  95      


Cys Glu Gly Glu Lys Arg Lys Leu Val Ile Pro Ser Glu Leu Gly Tyr 
            100                 105                 110         


Gly Glu Arg Gly Ala Pro Pro Lys Ile Pro Gly Gly Ala Thr Leu Val 
        115                 120                 125             


Phe Glu Val Glu Leu Leu Lys Ile Glu Arg Arg Thr Glu Leu 
    130                 135                 140         


<210>  5444
<211>  142
<212>  PRT
<213>  Homo Sapiens

<400>  5444

Met Arg Leu Ser Trp Phe Arg Val Leu Thr Val Leu Ser Ile Cys Leu 
1               5                   10                  15      


Ser Ala Val Ala Thr Ala Thr Gly Ala Glu Gly Lys Arg Lys Leu Gln 
            20                  25                  30          


Ile Gly Val Lys Lys Arg Val Asp His Cys Pro Ile Lys Ser Arg Lys 
        35                  40                  45              


Gly Asp Val Leu His Met His Tyr Thr Gly Lys Leu Glu Asp Gly Thr 
    50                  55                  60                  


Glu Phe Asp Ser Ser Leu Pro Gln Asn Gln Pro Phe Val Phe Ser Leu 
65                  70                  75                  80  


Gly Thr Gly Gln Val Ile Lys Gly Trp Asp Gln Gly Leu Leu Gly Met 
                85                  90                  95      


Cys Glu Gly Glu Lys Arg Lys Leu Val Ile Pro Ser Glu Leu Gly Tyr 
            100                 105                 110         


Gly Glu Arg Gly Ala Pro Pro Lys Ile Pro Gly Gly Ala Thr Leu Val 
        115                 120                 125             


Phe Glu Val Glu Leu Leu Lys Ile Glu Arg Arg Thr Glu Leu 
    130                 135                 140         


<210>  5445
<211>  74
<212>  PRT
<213>  Homo Sapiens

<400>  5445

Met Pro Lys Thr Met His Phe Leu Phe Arg Phe Ile Val Phe Phe Tyr 
1               5                   10                  15      


Leu Trp Gly Leu Phe Thr Ala Gln Arg Gln Lys Lys Glu Glu Ser Thr 
            20                  25                  30          


Glu Glu Val Lys Ile Glu Val Leu His Arg Pro Glu Asn Cys Ser Lys 
        35                  40                  45              


Thr Ser Lys Lys Gly Asp Leu Leu Asn Ala His Tyr Asp Gly Tyr Leu 
    50                  55                  60                  


Ala Lys Asp Gly Ser Lys Phe Tyr Cys Arg 
65                  70                  


<210>  5446
<211>  86
<212>  PRT
<213>  Homo Sapiens

<400>  5446

Met Pro Lys Thr Met His Phe Leu Phe Arg Phe Ile Val Phe Phe Tyr 
1               5                   10                  15      


Leu Trp Gly Leu Phe Thr Ala Gln Arg Gln Lys Lys Glu Glu Ser Thr 
            20                  25                  30          


Glu Glu Val Lys Ile Glu Val Leu His Arg Pro Glu Asn Cys Ser Lys 
        35                  40                  45              


Thr Ser Lys Lys Gly Asp Leu Leu Asn Ala His Tyr Asp Gly Tyr Leu 
    50                  55                  60                  


Ala Lys Asp Gly Ser Lys Phe Tyr Cys Ser Arg Arg Gln Asp Ser Thr 
65                  70                  75                  80  


Gly Cys Tyr Ile Asp Phe 
                85      


<210>  5447
<211>  222
<212>  PRT
<213>  Homo Sapiens

<400>  5447

Met Pro Lys Thr Met His Phe Leu Phe Arg Phe Ile Val Phe Phe Tyr 
1               5                   10                  15      


Leu Trp Gly Leu Phe Thr Ala Gln Arg Gln Lys Lys Glu Glu Ser Thr 
            20                  25                  30          


Glu Glu Val Lys Ile Glu Val Leu His Arg Pro Glu Asn Cys Ser Lys 
        35                  40                  45              


Thr Ser Lys Lys Gly Asp Leu Leu Asn Ala His Tyr Asp Gly Tyr Leu 
    50                  55                  60                  


Ala Lys Asp Gly Ser Lys Phe Tyr Cys Ser Arg Thr Gln Asn Glu Gly 
65                  70                  75                  80  


His Pro Lys Trp Phe Val Leu Gly Val Gly Gln Val Ile Lys Gly Leu 
                85                  90                  95      


Asp Ile Ala Met Thr Asp Met Cys Pro Gly Glu Lys Arg Lys Val Val 
            100                 105                 110         


Ile Pro Pro Ser Phe Ala Tyr Gly Lys Glu Gly Tyr Ala Glu Gly Lys 
        115                 120                 125             


Ile Pro Pro Asp Ala Thr Leu Ile Phe Glu Ile Glu Leu Tyr Ala Val 
    130                 135                 140                 


Thr Lys Gly Pro Arg Ser Ile Glu Thr Phe Lys Gln Ile Asp Met Asp 
145                 150                 155                 160 


Asn Asp Arg Gln Leu Ser Lys Ala Glu Ile Asn Leu Tyr Leu Gln Arg 
                165                 170                 175     


Glu Phe Glu Lys Asp Glu Lys Pro Arg Asp Lys Ser Tyr Gln Asp Ala 
            180                 185                 190         


Val Leu Glu Asp Ile Phe Lys Lys Asn Asp His Asp Gly Asp Gly Phe 
        195                 200                 205             


Ile Ser Pro Lys Glu Tyr Asn Val Tyr Gln His Asp Glu Leu 
    210                 215                 220         


<210>  5448
<211>  221
<212>  PRT
<213>  Homo Sapiens

<400>  5448

Met Pro Lys Thr Met His Phe Leu Phe Arg Phe Ile Val Phe Phe Tyr 
1               5                   10                  15      


Leu Trp Gly Leu Phe Thr Ala Gln Arg Gln Lys Lys Glu Glu Ser Thr 
            20                  25                  30          


Glu Glu Val Lys Ile Glu Val Leu His Arg Pro Glu Asn Cys Ser Lys 
        35                  40                  45              


Thr Ser Lys Lys Gly Asp Leu Leu Asn Ala His Tyr Asp Gly Tyr Leu 
    50                  55                  60                  


Ala Lys Asp Gly Ser Lys Phe Tyr Cys Ser Arg Thr Gln Asn Glu Gly 
65                  70                  75                  80  


His Pro Lys Trp Phe Val Leu Gly Val Gly Gln Val Ile Lys Gly Leu 
                85                  90                  95      


Asp Ile Ala Met Thr Asp Met Cys Pro Gly Glu Lys Arg Lys Val Val 
            100                 105                 110         


Ile Pro Pro Ser Phe Ala Tyr Gly Lys Glu Gly Tyr Glu Gly Lys Ile 
        115                 120                 125             


Pro Pro Asp Ala Thr Leu Ile Phe Glu Ile Glu Leu Tyr Ala Val Thr 
    130                 135                 140                 


Lys Gly Pro Arg Ser Ile Glu Thr Phe Lys Gln Ile Asp Met Asp Asn 
145                 150                 155                 160 


Asp Arg Gln Leu Ser Lys Ala Glu Ile Asn Leu Tyr Leu Gln Arg Glu 
                165                 170                 175     


Phe Glu Lys Asp Glu Lys Pro Arg Asp Lys Ser Tyr Gln Asp Ala Val 
            180                 185                 190         


Leu Glu Asp Ile Phe Lys Lys Asn Asp His Asp Gly Asp Gly Phe Ile 
        195                 200                 205             


Ser Pro Lys Glu Tyr Asn Val Tyr Gln His Asp Glu Leu 
    210                 215                 220     


<210>  5449
<211>  127
<212>  PRT
<213>  Homo Sapiens

<400>  5449

Met Pro Lys Thr Met His Phe Leu Phe Arg Phe Ile Val Phe Phe Tyr 
1               5                   10                  15      


Leu Trp Gly Leu Phe Thr Ala Gln Arg Gln Lys Lys Glu Glu Ser Thr 
            20                  25                  30          


Glu Glu Val Lys Ile Glu Val Leu His Arg Pro Glu Asn Cys Ser Lys 
        35                  40                  45              


Thr Ser Lys Lys Gly Asp Leu Leu Asn Ala His Tyr Asp Gly Tyr Leu 
    50                  55                  60                  


Ala Lys Asp Gly Ser Lys Phe Tyr Cys Ser Arg Thr Gln Asn Glu Gly 
65                  70                  75                  80  


His Pro Lys Trp Phe Val Leu Gly Val Gly Gln Val Ile Lys Gly Leu 
                85                  90                  95      


Asp Ile Ala Met Thr Asp Met Cys Pro Gly Glu Lys Arg Lys Val Val 
            100                 105                 110         


Ile Pro Pro Ser Phe Ala Tyr Gly Lys Glu Gly Tyr Gly Ser Thr 
        115                 120                 125         


<210>  5450
<211>  67
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5450

Xaa Gly Tyr Leu Ala Lys Asp Gly Ser Lys Phe Tyr Cys Ser Arg Thr 
1               5                   10                  15      


Gln Asn Glu Gly His Pro Lys Trp Phe Val Leu Gly Val Gly Gln Val 
            20                  25                  30          


Ile Lys Gly Leu Asp Ile Ala Met Thr Asp Met Cys Pro Gly Glu Lys 
        35                  40                  45              


Arg Lys Val Val Ile Pro Pro Ser Phe Ala Tyr Gly Lys Glu Gly Tyr 
    50                  55                  60                  


Gly Ser Thr 
65          


<210>  5451
<211>  623
<212>  PRT
<213>  Homo Sapiens

<400>  5451

Met Ala Phe Arg Gly Trp Arg Pro Pro Pro Pro Pro Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Trp Val Thr Gly Gln Ala Ala Pro Val Ala Gly Leu Gly Ser 
            20                  25                  30          


Asp Ala Glu Leu Gln Ile Glu Arg Arg Phe Val Pro Asp Glu Cys Pro 
        35                  40                  45              


Arg Thr Val Arg Ser Gly Asp Phe Val Arg Tyr His Tyr Val Gly Thr 
    50                  55                  60                  


Phe Pro Asp Gly Gln Lys Phe Asp Ser Arg Tyr Trp Asp Thr Ala Glu 
65                  70                  75                  80  


Asp Lys Ala Asp Lys Ser Pro Cys Pro Gln Val Arg Val Gly Val Asn 
                85                  90                  95      


Thr Ser Pro Ser Cys Arg Leu Lys Gln Lys Gly Val Gly Ile Tyr Trp 
            100                 105                 110         


Lys Asp Leu Gln Phe Leu Val Arg Val Gln Asn His Gly Leu Ser Tyr 
        115                 120                 125             


Asp Arg Asp Ser Thr Phe Asn Val Phe Val Gly Lys Gly Gln Leu Ile 
    130                 135                 140                 


Thr Gly Met Asp Gln Ala Leu Val Gly Met Cys Val Asn Glu Arg Arg 
145                 150                 155                 160 


Phe Val Lys Ile Pro Pro Lys Leu Ala Tyr Gly Asn Glu Gly Val Ser 
                165                 170                 175     


Gly Val Ile Pro Pro Asn Ser Val Leu His Phe Asp Val Leu Leu Met 
            180                 185                 190         


Asp Ile Trp Asn Ser Glu Asp Gln Val Gln Ile His Thr Tyr Phe Lys 
        195                 200                 205             


Pro Pro Ser Cys Pro Arg Thr Ile Gln Val Ser Asp Phe Val Arg Tyr 
    210                 215                 220                 


His Tyr Asn Gly Thr Phe Leu Asp Gly Thr Leu Phe Asp Ser Ser His 
225                 230                 235                 240 


Asn Arg Met Lys Thr Tyr Asp Thr Tyr Val Gly Ile Gly Trp Leu Ile 
                245                 250                 255     


Pro Gly Met Asp Lys Gly Leu Leu Gly Met Cys Val Gly Glu Lys Arg 
            260                 265                 270         


Ile Ile Thr Ile Pro Pro Phe Leu Ala Tyr Gly Glu Asp Gly Asp Gly 
        275                 280                 285             


Lys Asp Ile Pro Gly Gln Ala Ser Leu Val Phe Asp Val Ala Leu Leu 
    290                 295                 300                 


Asp Leu His Asn Pro Lys Asp Ser Ile Ser Ile Glu Asn Lys Val Val 
305                 310                 315                 320 


Pro Glu Asn Cys Glu Arg Ile Ser Gln Ser Gly Asp Phe Leu Arg Tyr 
                325                 330                 335     


His Tyr Asn Gly Thr Leu Leu Asp Gly Thr Leu Phe Asp Ser Ser Tyr 
            340                 345                 350         


Ser Arg Asn Arg Thr Phe Asp Thr Tyr Ile Gly Gln Gly Tyr Val Ile 
        355                 360                 365             


Pro Gly Met Asp Glu Gly Leu Leu Gly Val Cys Ile Gly Glu Lys Arg 
    370                 375                 380                 


Arg Ile Val Val Pro Pro His Leu Gly Tyr Gly Glu Glu Gly Arg Gly 
385                 390                 395                 400 


Asn Ile Pro Gly Ser Ala Val Leu Val Phe Asp Ile His Val Ile Asp 
                405                 410                 415     


Phe His Asn Pro Ser Asp Ser Ile Ser Ile Thr Ser His Tyr Lys Pro 
            420                 425                 430         


Pro Asp Cys Ser Val Leu Ser Lys Lys Gly Asp Tyr Leu Lys Tyr His 
        435                 440                 445             


Tyr Asn Ala Ser Leu Leu Asp Gly Thr Leu Leu Asp Ser Thr Trp Asn 
    450                 455                 460                 


Leu Gly Lys Thr Tyr Asn Ile Val Leu Gly Ser Gly Gln Val Val Leu 
465                 470                 475                 480 


Gly Met Asp Met Gly Leu Arg Glu Met Cys Val Gly Glu Lys Arg Thr 
                485                 490                 495     


Val Ile Ile Pro Pro His Leu Gly Tyr Gly Glu Ala Gly Val Asp Gly 
            500                 505                 510         


Glu Val Pro Gly Ser Ala Val Leu Val Phe Asp Ile Glu Leu Leu Glu 
        515                 520                 525             


Leu Val Ala Gly Leu Pro Glu Gly Tyr Met Phe Ile Trp Asn Gly Glu 
    530                 535                 540                 


Val Ser Pro Asn Leu Phe Glu Glu Ile Asp Lys Asp Gly Asn Gly Glu 
545                 550                 555                 560 


Val Leu Leu Glu Glu Phe Ser Glu Tyr Ile His Ala Gln Val Ala Ser 
                565                 570                 575     


Gly Lys Gly Lys Leu Ala Pro Gly Phe Asp Ala Glu Leu Ile Val Lys 
            580                 585                 590         


Asn Met Phe Thr Asn Gln Asp Arg Asn Gly Asp Gly Lys Val Thr Ala 
        595                 600                 605             


Glu Glu Phe Lys Leu Lys Asp Gln Glu Ala Lys His Asp Glu Leu 
    610                 615                 620             


<210>  5452
<211>  570
<212>  PRT
<213>  Homo Sapiens

<400>  5452

Met Ala Phe Arg Gly Trp Arg Pro Pro Pro Pro Pro Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Trp Val Thr Gly Gln Ala Ala Pro Val Ala Gly Leu Gly Ser 
            20                  25                  30          


Asp Ala Glu Leu Gln Ile Glu Arg Arg Phe Val Pro Asp Glu Cys Pro 
        35                  40                  45              


Arg Thr Val Arg Ser Gly Asp Phe Val Arg Tyr His Tyr Val Gly Thr 
    50                  55                  60                  


Phe Pro Asp Gly Gln Lys Phe Asp Ser Ser Tyr Asp Arg Asp Ser Thr 
65                  70                  75                  80  


Phe Asn Val Phe Val Gly Lys Gly Gln Leu Ile Thr Gly Met Asp Gln 
                85                  90                  95      


Ala Leu Val Gly Met Cys Val Asn Glu Arg Arg Phe Val Lys Ile Pro 
            100                 105                 110         


Pro Lys Leu Ala Tyr Gly Asn Glu Gly Val Ser Gly Val Ile Pro Pro 
        115                 120                 125             


Asn Ser Val Leu His Phe Asp Val Leu Leu Met Asp Ile Trp Asn Ser 
    130                 135                 140                 


Glu Asp Gln Val Gln Ile His Thr Tyr Phe Lys Pro Pro Ser Cys Pro 
145                 150                 155                 160 


Arg Thr Ile Gln Val Ser Asp Phe Val Arg Tyr His Tyr Asn Gly Thr 
                165                 170                 175     


Phe Leu Asp Gly Thr Leu Phe Asp Ser Ser His Asn Arg Met Lys Thr 
            180                 185                 190         


Tyr Asp Thr Tyr Val Gly Ile Gly Trp Leu Ile Pro Gly Met Asp Lys 
        195                 200                 205             


Gly Leu Leu Gly Met Cys Val Gly Glu Lys Arg Ile Ile Thr Ile Pro 
    210                 215                 220                 


Pro Phe Leu Ala Tyr Gly Glu Asp Gly Asp Gly Lys Asp Ile Pro Gly 
225                 230                 235                 240 


Gln Ala Ser Leu Val Phe Asp Val Ala Leu Leu Asp Leu His Asn Pro 
                245                 250                 255     


Lys Asp Ser Ile Ser Ile Glu Asn Lys Val Val Pro Glu Asn Cys Glu 
            260                 265                 270         


Arg Ile Ser Gln Ser Gly Asp Phe Leu Arg Tyr His Tyr Asn Gly Thr 
        275                 280                 285             


Leu Leu Asp Gly Thr Leu Phe Asp Ser Ser Tyr Ser Arg Asn Arg Thr 
    290                 295                 300                 


Phe Asp Thr Tyr Ile Gly Gln Gly Tyr Val Ile Pro Gly Met Asp Glu 
305                 310                 315                 320 


Gly Leu Leu Gly Val Cys Ile Gly Glu Lys Arg Arg Ile Val Val Pro 
                325                 330                 335     


Pro His Leu Gly Tyr Gly Glu Glu Gly Arg Gly Asn Ile Pro Gly Ser 
            340                 345                 350         


Ala Val Leu Val Phe Asp Ile His Val Ile Asp Phe His Asn Pro Ser 
        355                 360                 365             


Asp Ser Ile Ser Ile Thr Ser His Tyr Lys Pro Pro Asp Cys Ser Val 
    370                 375                 380                 


Leu Ser Lys Lys Gly Asp Tyr Leu Lys Tyr His Tyr Asn Ala Ser Leu 
385                 390                 395                 400 


Leu Asp Gly Thr Leu Leu Asp Ser Thr Trp Asn Leu Gly Lys Thr Tyr 
                405                 410                 415     


Asn Ile Val Leu Gly Ser Gly Gln Val Val Leu Gly Met Asp Met Gly 
            420                 425                 430         


Leu Arg Glu Met Cys Val Gly Glu Lys Arg Thr Val Ile Ile Pro Pro 
        435                 440                 445             


His Leu Gly Tyr Gly Glu Ala Gly Val Asp Gly Glu Val Pro Gly Ser 
    450                 455                 460                 


Ala Val Leu Val Phe Asp Ile Glu Leu Leu Glu Leu Val Ala Gly Leu 
465                 470                 475                 480 


Pro Glu Gly Tyr Met Phe Ile Trp Asn Gly Glu Val Ser Pro Asn Leu 
                485                 490                 495     


Phe Glu Glu Ile Asp Lys Asp Gly Asn Gly Glu Val Leu Leu Glu Glu 
            500                 505                 510         


Phe Ser Glu Tyr Ile His Ala Gln Val Ala Ser Gly Lys Gly Lys Leu 
        515                 520                 525             


Ala Pro Gly Phe Asp Ala Glu Leu Ile Val Lys Asn Met Phe Thr Asn 
    530                 535                 540                 


Gln Asp Arg Asn Gly Asp Gly Lys Val Thr Ala Glu Glu Phe Lys Leu 
545                 550                 555                 560 


Lys Asp Gln Glu Ala Lys His Asp Glu Leu 
                565                 570 


<210>  5453
<211>  338
<212>  PRT
<213>  Homo Sapiens

<400>  5453

Met Ala Gly Lys Asp Ile Pro Gly Gln Ala Ser Leu Val Phe Asp Val 
1               5                   10                  15      


Ala Leu Leu Asp Leu His Asn Pro Lys Asp Ser Ile Ser Ile Glu Asn 
            20                  25                  30          


Lys Val Val Pro Glu Asn Cys Glu Arg Ile Ser Gln Ser Gly Asp Phe 
        35                  40                  45              


Leu Arg Tyr His Tyr Asn Gly Thr Leu Leu Asp Gly Thr Leu Phe Asp 
    50                  55                  60                  


Ser Ser Tyr Ser Arg Asn Arg Thr Phe Asp Thr Tyr Ile Gly Gln Gly 
65                  70                  75                  80  


Tyr Val Ile Pro Gly Met Asp Glu Gly Leu Leu Gly Val Cys Ile Gly 
                85                  90                  95      


Glu Lys Arg Arg Ile Val Val Pro Pro His Leu Gly Tyr Gly Glu Glu 
            100                 105                 110         


Gly Arg Gly Asn Ile Pro Gly Ser Ala Val Leu Val Phe Asp Ile His 
        115                 120                 125             


Val Ile Asp Phe His Asn Pro Ser Asp Ser Ile Ser Ile Thr Ser His 
    130                 135                 140                 


Tyr Lys Pro Pro Asp Cys Ser Val Leu Ser Lys Lys Gly Asp Tyr Leu 
145                 150                 155                 160 


Lys Tyr His Tyr Asn Ala Ser Leu Leu Asp Gly Thr Leu Leu Asp Ser 
                165                 170                 175     


Thr Trp Asn Leu Gly Lys Thr Tyr Asn Ile Val Leu Gly Ser Gly Gln 
            180                 185                 190         


Val Val Leu Gly Met Asp Met Gly Leu Arg Glu Met Cys Val Gly Glu 
        195                 200                 205             


Lys Arg Thr Val Ile Ile Pro Pro His Leu Gly Tyr Gly Glu Ala Gly 
    210                 215                 220                 


Val Asp Gly Glu Val Pro Gly Ser Ala Val Leu Val Phe Asp Ile Glu 
225                 230                 235                 240 


Leu Leu Glu Leu Val Ala Gly Leu Pro Glu Gly Tyr Met Phe Ile Trp 
                245                 250                 255     


Asn Gly Glu Val Ser Pro Asn Leu Phe Glu Glu Ile Asp Lys Asp Gly 
            260                 265                 270         


Asn Gly Glu Val Leu Leu Glu Glu Phe Ser Glu Tyr Ile His Ala Gln 
        275                 280                 285             


Val Ala Ser Gly Lys Gly Lys Leu Ala Pro Gly Phe Asp Ala Glu Leu 
    290                 295                 300                 


Ile Val Lys Asn Met Phe Thr Asn Gln Asp Arg Asn Gly Asp Gly Lys 
305                 310                 315                 320 


Val Thr Ala Glu Glu Phe Lys Leu Lys Asp Gln Glu Ala Lys His Asp 
                325                 330                 335     


Glu Leu 
        


<210>  5454
<211>  226
<212>  PRT
<213>  Homo Sapiens

<400>  5454

Met Ala Gly Lys Asp Ile Pro Gly Gln Ala Ser Leu Val Phe Asp Val 
1               5                   10                  15      


Ala Leu Leu Asp Leu His Asn Pro Lys Asp Ser Ile Ser Ile Glu Asn 
            20                  25                  30          


Lys Val Val Pro Glu Asn Cys Glu Arg Ile Ser Gln Ser Gly Asp Phe 
        35                  40                  45              


Leu Arg Tyr His Tyr Asn Gly Thr Leu Leu Asp Gly Thr Leu Phe Asp 
    50                  55                  60                  


Ser Ser Tyr Ser Arg Asn Arg Thr Phe Asp Thr Tyr Ile Gly Gln Gly 
65                  70                  75                  80  


Tyr Val Ile Pro Gly Met Asp Glu Gly Leu Leu Gly Val Cys Ile Gly 
                85                  90                  95      


Glu Lys Arg Arg Ile Val Val Pro Pro His Leu Gly Tyr Gly Glu Glu 
            100                 105                 110         


Gly Arg Gly Asn Ile Pro Gly Ser Ala Val Leu Val Phe Asp Ile His 
        115                 120                 125             


Val Ile Asp Phe His Asn Pro Ser Asp Ser Ile Ser Ile Thr Ser His 
    130                 135                 140                 


Tyr Lys Pro Pro Asp Cys Ser Val Leu Ser Lys Lys Gly Asp Tyr Leu 
145                 150                 155                 160 


Lys Tyr His Tyr Asn Ala Ser Leu Leu Asp Gly Thr Leu Leu Asp Ser 
                165                 170                 175     


Thr Trp Asn Leu Gly Lys Thr Tyr Asn Ile Val Leu Gly Ser Gly Gln 
            180                 185                 190         


Val Val Leu Gly Met Asp Met Gly Leu Arg Glu Met Cys Val Gly Glu 
        195                 200                 205             


Lys Arg Thr Val Ile Ile Pro Pro His Leu Gly Tyr Gly Glu Ala Gly 
    210                 215                 220                 


Val Gly 
225     


<210>  5455
<211>  85
<212>  PRT
<213>  Homo Sapiens

<400>  5455

Met Leu Lys Arg Phe Thr Trp Thr Asp Ser Lys Pro Lys Ala Ser Leu 
1               5                   10                  15      


Lys Ile Asp Leu Arg Val Thr Ser Lys Ser Lys Glu Ser Gly Leu Ser 
            20                  25                  30          


Asp Val Ser Arg Pro Ser Phe Cys His Ser Ser Cys Gly His Val Ser 
        35                  40                  45              


Glu Gly Lys Arg Arg Phe Thr Tyr Asp His Ala Glu Leu Glu Arg Lys 
    50                  55                  60                  


Ile Ala Cys Cys Ser Pro Pro Pro Asp Tyr Asn Ser Val Val Leu Tyr 
65                  70                  75                  80  


Ser Thr Pro Pro Ile 
                85  


<210>  5456
<211>  85
<212>  PRT
<213>  Homo Sapiens

<400>  5456

Met Leu Lys Arg Phe Thr Trp Thr Asp Ser Lys Pro Lys Ala Ser Leu 
1               5                   10                  15      


Lys Ile Asp Leu Arg Val Thr Ser Lys Ser Lys Glu Ser Gly Leu Ser 
            20                  25                  30          


Asp Val Ser Arg Pro Ser Phe Cys His Ser Ser Cys Gly His Val Ser 
        35                  40                  45              


Glu Gly Lys Arg Arg Phe Thr Tyr Asp His Ala Glu Leu Glu Arg Lys 
    50                  55                  60                  


Ile Ala Cys Cys Ser Pro Pro Pro Asp Tyr Asn Ser Val Val Leu Tyr 
65                  70                  75                  80  


Ser Thr Pro Pro Ile 
                85  


<210>  5457
<211>  361
<212>  PRT
<213>  Homo Sapiens

<400>  5457

Met Asn Ser Asp Leu Leu Val Asp Ser Asp Gly Phe Tyr Lys Glu Pro 
1               5                   10                  15      


Ile Thr Met Glu Asp Leu Ile Ser Tyr Ser Phe Gln Val Ala Arg Gly 
            20                  25                  30          


Met Glu Phe Leu Ser Ser Arg Lys Cys Ile His Arg Asp Leu Ala Ala 
        35                  40                  45              


Arg Asn Ile Leu Leu Ser Glu Asn Asn Val Val Lys Ile Cys Asp Phe 
    50                  55                  60                  


Gly Leu Ala Arg Asp Ile Tyr Lys Asn Pro Asp Tyr Val Arg Lys Gly 
65                  70                  75                  80  


Asp Thr Arg Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asp 
                85                  90                  95      


Lys Ile Tyr Ser Thr Lys Ser Asp Val Trp Ser Tyr Gly Val Leu Leu 
            100                 105                 110         


Trp Glu Ile Phe Ser Leu Gly Gly Ser Pro Tyr Pro Gly Val Gln Met 
        115                 120                 125             


Asp Glu Asp Phe Cys Ser Arg Leu Arg Glu Gly Met Arg Met Arg Ala 
    130                 135                 140                 


Pro Glu Tyr Ser Thr Pro Glu Ile Tyr Gln Ile Met Leu Asp Cys Trp 
145                 150                 155                 160 


His Arg Asp Pro Lys Glu Arg Pro Arg Phe Ala Glu Leu Val Glu Lys 
                165                 170                 175     


Leu Gly Asp Leu Leu Gln Ala Asn Val Gln Gln Asp Gly Lys Asp Tyr 
            180                 185                 190         


Ile Pro Ile Asn Ala Ile Leu Thr Gly Asn Ser Gly Phe Thr Tyr Ser 
        195                 200                 205             


Thr Pro Ala Phe Ser Glu Asp Phe Phe Lys Glu Ser Ile Ser Ala Pro 
    210                 215                 220                 


Lys Phe Asn Ser Gly Ser Ser Asp Asp Val Arg Tyr Val Asn Ala Phe 
225                 230                 235                 240 


Lys Phe Met Ser Leu Glu Arg Ile Lys Thr Phe Glu Glu Leu Leu Pro 
                245                 250                 255     


Asn Ala Thr Ser Met Phe Asp Asp Tyr Gln Gly Asp Ser Ser Thr Leu 
            260                 265                 270         


Leu Ala Ser Pro Met Leu Lys Arg Phe Thr Trp Thr Asp Ser Lys Pro 
        275                 280                 285             


Lys Ala Ser Leu Lys Ile Asp Leu Arg Val Thr Ser Lys Ser Lys Glu 
    290                 295                 300                 


Ser Gly Leu Ser Asp Val Ser Arg Pro Ser Phe Cys His Ser Ser Cys 
305                 310                 315                 320 


Gly His Val Ser Glu Gly Lys Arg Arg Phe Thr Tyr Asp His Ala Glu 
                325                 330                 335     


Leu Glu Arg Lys Ile Ala Cys Cys Ser Pro Pro Pro Asp Tyr Asn Ser 
            340                 345                 350         


Val Val Leu Tyr Ser Thr Pro Pro Ile 
        355                 360     


<210>  5458
<211>  433
<212>  PRT
<213>  Homo Sapiens

<400>  5458

Met Val Ile Val Glu Tyr Cys Lys Tyr Gly Asn Leu Ser Asn Tyr Leu 
1               5                   10                  15      


Lys Ser Lys Arg Asp Leu Phe Phe Leu Asn Lys Asp Ala Ala Leu His 
            20                  25                  30          


Met Glu Pro Lys Lys Glu Lys Met Glu Pro Gly Leu Glu Gln Gly Lys 
        35                  40                  45              


Lys Pro Arg Leu Asp Ser Val Thr Ser Ser Glu Ser Phe Ala Ser Ser 
    50                  55                  60                  


Gly Phe Gln Glu Asp Lys Ser Leu Ser Asp Val Glu Glu Glu Glu Asp 
65                  70                  75                  80  


Ser Asp Gly Phe Tyr Lys Glu Pro Ile Thr Met Glu Asp Leu Ile Ser 
                85                  90                  95      


Tyr Ser Phe Gln Val Ala Arg Gly Met Glu Phe Leu Ser Ser Arg Lys 
            100                 105                 110         


Cys Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu Ser Glu Asn 
        115                 120                 125             


Asn Val Val Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp Ile Tyr Lys 
    130                 135                 140                 


Asn Pro Asp Tyr Val Arg Lys Gly Asp Thr Arg Leu Pro Leu Lys Trp 
145                 150                 155                 160 


Met Ala Pro Glu Ser Ile Phe Asp Lys Ile Tyr Ser Thr Lys Ser Asp 
                165                 170                 175     


Val Trp Ser Tyr Gly Val Leu Leu Trp Glu Ile Phe Ser Leu Gly Gly 
            180                 185                 190         


Ser Pro Tyr Pro Gly Val Gln Met Asp Glu Asp Phe Cys Ser Arg Leu 
        195                 200                 205             


Arg Glu Gly Met Arg Met Arg Ala Pro Glu Tyr Ser Thr Pro Glu Ile 
    210                 215                 220                 


Tyr Gln Ile Met Leu Asp Cys Trp His Arg Asp Pro Lys Glu Arg Pro 
225                 230                 235                 240 


Arg Phe Ala Glu Leu Val Glu Lys Leu Gly Asp Leu Leu Gln Ala Asn 
                245                 250                 255     


Val Gln Gln Asp Gly Lys Asp Tyr Ile Pro Ile Asn Ala Ile Leu Thr 
            260                 265                 270         


Gly Asn Ser Gly Phe Thr Tyr Ser Thr Pro Ala Phe Ser Glu Asp Phe 
        275                 280                 285             


Phe Lys Glu Ser Ile Ser Ala Pro Lys Phe Asn Ser Gly Ser Ser Asp 
    290                 295                 300                 


Asp Val Arg Tyr Val Asn Ala Phe Lys Phe Met Ser Leu Glu Arg Ile 
305                 310                 315                 320 


Lys Thr Phe Glu Glu Leu Leu Pro Asn Ala Thr Ser Met Phe Asp Asp 
                325                 330                 335     


Tyr Gln Gly Asp Ser Ser Thr Leu Leu Ala Ser Pro Met Leu Lys Arg 
            340                 345                 350         


Phe Thr Trp Thr Asp Ser Lys Pro Lys Ala Ser Leu Lys Ile Asp Leu 
        355                 360                 365             


Arg Val Thr Ser Lys Ser Lys Glu Ser Gly Leu Ser Asp Val Ser Arg 
    370                 375                 380                 


Pro Ser Phe Cys His Ser Ser Cys Gly His Val Ser Glu Gly Lys Arg 
385                 390                 395                 400 


Arg Phe Thr Tyr Asp His Ala Glu Leu Glu Arg Lys Ile Ala Cys Cys 
                405                 410                 415     


Ser Pro Pro Pro Asp Tyr Asn Ser Val Val Leu Tyr Ser Thr Pro Pro 
            420                 425                 430         


Ile 
    


<210>  5459
<211>  1338
<212>  PRT
<213>  Homo Sapiens

<400>  5459

Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro 
            20                  25                  30          


Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr 
        35                  40                  45              


Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro 
    50                  55                  60                  


Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala 
65                  70                  75                  80  


Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr 
                85                  90                  95      


Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val 
            100                 105                 110         


Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile 
        115                 120                 125             


Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
    130                 135                 140                 


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
145                 150                 155                 160 


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
                165                 170                 175     


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
            180                 185                 190         


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
        195                 200                 205             


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
    210                 215                 220                 


Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val 
225                 230                 235                 240 


Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr 
                245                 250                 255     


Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys 
            260                 265                 270         


Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His 
        275                 280                 285             


Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys 
    290                 295                 300                 


Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys 
305                 310                 315                 320 


Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys Ala Phe Ile Thr Val 
                325                 330                 335     


Lys His Arg Lys Gln Gln Val Leu Glu Thr Val Ala Gly Lys Arg Ser 
            340                 345                 350         


Tyr Arg Leu Ser Met Lys Val Lys Ala Phe Pro Ser Pro Glu Val Val 
        355                 360                 365             


Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu Lys Ser Ala Arg Tyr Leu 
    370                 375                 380                 


Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp Val Thr Glu Glu Asp Ala 
385                 390                 395                 400 


Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys Gln Ser Asn Val Phe Lys 
                405                 410                 415     


Asn Leu Thr Ala Thr Leu Ile Val Asn Val Lys Pro Gln Ile Tyr Glu 
            420                 425                 430         


Lys Ala Val Ser Ser Phe Pro Asp Pro Ala Leu Tyr Pro Leu Gly Ser 
        435                 440                 445             


Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly Ile Pro Gln Pro Thr Ile 
    450                 455                 460                 


Lys Trp Phe Trp His Pro Cys Asn His Asn His Ser Glu Ala Arg Cys 
465                 470                 475                 480 


Asp Phe Cys Ser Asn Asn Glu Glu Ser Phe Ile Leu Asp Ala Asp Ser 
                485                 490                 495     


Asn Met Gly Asn Arg Ile Glu Ser Ile Thr Gln Arg Met Ala Ile Ile 
            500                 505                 510         


Glu Gly Lys Asn Lys Met Ala Ser Thr Leu Val Val Ala Asp Ser Arg 
        515                 520                 525             


Ile Ser Gly Ile Tyr Ile Cys Ile Ala Ser Asn Lys Val Gly Thr Val 
    530                 535                 540                 


Gly Arg Asn Ile Ser Phe Tyr Ile Thr Asp Val Pro Asn Gly Phe His 
545                 550                 555                 560 


Val Asn Leu Glu Lys Met Pro Thr Glu Gly Glu Asp Leu Lys Leu Ser 
                565                 570                 575     


Cys Thr Val Asn Lys Phe Leu Tyr Arg Asp Val Thr Trp Ile Leu Leu 
            580                 585                 590         


Arg Thr Val Asn Asn Arg Thr Met His Tyr Ser Ile Ser Lys Gln Lys 
        595                 600                 605             


Met Ala Ile Thr Lys Glu His Ser Ile Thr Leu Asn Leu Thr Ile Met 
    610                 615                 620                 


Asn Val Ser Leu Gln Asp Ser Gly Thr Tyr Ala Cys Arg Ala Arg Asn 
625                 630                 635                 640 


Val Tyr Thr Gly Glu Glu Ile Leu Gln Lys Lys Glu Ile Thr Ile Arg 
                645                 650                 655     


Asp Gln Glu Ala Pro Tyr Leu Leu Arg Asn Leu Ser Asp His Thr Val 
            660                 665                 670         


Ala Ile Ser Ser Ser Thr Thr Leu Asp Cys His Ala Asn Gly Val Pro 
        675                 680                 685             


Glu Pro Gln Ile Thr Trp Phe Lys Asn Asn His Lys Ile Gln Gln Glu 
    690                 695                 700                 


Pro Gly Ile Ile Leu Gly Pro Gly Ser Ser Thr Leu Phe Ile Glu Arg 
705                 710                 715                 720 


Val Thr Glu Glu Asp Glu Gly Val Tyr His Cys Lys Ala Thr Asn Gln 
                725                 730                 735     


Lys Gly Ser Val Glu Ser Ser Ala Tyr Leu Thr Val Gln Gly Thr Ser 
            740                 745                 750         


Asp Lys Ser Asn Leu Glu Leu Ile Thr Leu Thr Cys Thr Cys Val Ala 
        755                 760                 765             


Ala Thr Leu Phe Trp Leu Leu Leu Thr Leu Phe Ile Arg Lys Met Lys 
    770                 775                 780                 


Arg Ser Ser Ser Glu Ile Lys Thr Asp Tyr Leu Ser Ile Ile Met Asp 
785                 790                 795                 800 


Pro Asp Glu Val Pro Leu Asp Glu Gln Cys Glu Arg Leu Pro Tyr Asp 
                805                 810                 815     


Ala Ser Lys Trp Glu Phe Ala Arg Glu Arg Leu Lys Leu Gly Lys Ser 
            820                 825                 830         


Leu Gly Arg Gly Ala Phe Gly Lys Val Val Gln Ala Ser Ala Phe Gly 
        835                 840                 845             


Ile Lys Lys Ser Pro Thr Cys Arg Thr Val Ala Val Lys Met Leu Lys 
    850                 855                 860                 


Glu Gly Ala Thr Ala Ser Glu Tyr Lys Ala Leu Met Thr Glu Leu Lys 
865                 870                 875                 880 


Ile Leu Thr His Ile Gly His His Leu Asn Val Val Asn Leu Leu Gly 
                885                 890                 895     


Ala Cys Thr Lys Gln Gly Gly Pro Leu Met Val Ile Val Glu Tyr Cys 
            900                 905                 910         


Lys Tyr Gly Asn Leu Ser Asn Tyr Leu Lys Ser Lys Arg Asp Leu Phe 
        915                 920                 925             


Phe Leu Asn Lys Asp Ala Ala Leu His Met Glu Pro Lys Lys Glu Lys 
    930                 935                 940                 


Met Glu Pro Gly Leu Glu Gln Gly Lys Lys Pro Arg Leu Asp Ser Val 
945                 950                 955                 960 


Thr Ser Ser Glu Ser Phe Ala Ser Ser Gly Phe Gln Glu Asp Lys Ser 
                965                 970                 975     


Leu Ser Asp Val Glu Glu Glu Glu Asp Ser Asp Gly Phe Tyr Lys Glu 
            980                 985                 990         


Pro Ile Thr Met Glu Asp Leu Ile  Ser Tyr Ser Phe Gln  Val Ala Arg 
        995                 1000                 1005             


Gly Met  Glu Phe Leu Ser Ser  Arg Lys Cys Ile His  Arg Asp Leu 
    1010                 1015                 1020             


Ala Ala  Arg Asn Ile Leu Leu  Ser Glu Asn Asn Val  Val Lys Ile 
    1025                 1030                 1035             


Cys Asp  Phe Gly Leu Ala Arg  Asp Ile Tyr Lys Asn  Pro Asp Tyr 
    1040                 1045                 1050             


Val Arg  Lys Gly Asp Thr Arg  Leu Pro Leu Lys Trp  Met Ala Pro 
    1055                 1060                 1065             


Glu Ser  Ile Phe Asp Lys Ile  Tyr Ser Thr Lys Ser  Asp Val Trp 
    1070                 1075                 1080             


Ser Tyr  Gly Val Leu Leu Trp  Glu Ile Phe Ser Leu  Gly Gly Ser 
    1085                 1090                 1095             


Pro Tyr  Pro Gly Val Gln Met  Asp Glu Asp Phe Cys  Ser Arg Leu 
    1100                 1105                 1110             


Arg Glu  Gly Met Arg Met Arg  Ala Pro Glu Tyr Ser  Thr Pro Glu 
    1115                 1120                 1125             


Ile Tyr  Gln Ile Met Leu Asp  Cys Trp His Arg Asp  Pro Lys Glu 
    1130                 1135                 1140             


Arg Pro  Arg Phe Ala Glu Leu  Val Glu Lys Leu Gly  Asp Leu Leu 
    1145                 1150                 1155             


Gln Ala  Asn Val Gln Gln Asp  Gly Lys Asp Tyr Ile  Pro Ile Asn 
    1160                 1165                 1170             


Ala Ile  Leu Thr Gly Asn Ser  Gly Phe Thr Tyr Ser  Thr Pro Ala 
    1175                 1180                 1185             


Phe Ser  Glu Asp Phe Phe Lys  Glu Ser Ile Ser Ala  Pro Lys Phe 
    1190                 1195                 1200             


Asn Ser  Gly Ser Ser Asp Asp  Val Arg Tyr Val Asn  Ala Phe Lys 
    1205                 1210                 1215             


Phe Met  Ser Leu Glu Arg Ile  Lys Thr Phe Glu Glu  Leu Leu Pro 
    1220                 1225                 1230             


Asn Ala  Thr Ser Met Phe Asp  Asp Tyr Gln Gly Asp  Ser Ser Thr 
    1235                 1240                 1245             


Leu Leu  Ala Ser Pro Met Leu  Lys Arg Phe Thr Trp  Thr Asp Ser 
    1250                 1255                 1260             


Lys Pro  Lys Ala Ser Leu Lys  Ile Asp Leu Arg Val  Thr Ser Lys 
    1265                 1270                 1275             


Ser Lys  Glu Ser Gly Leu Ser  Asp Val Ser Arg Pro  Ser Phe Cys 
    1280                 1285                 1290             


His Ser  Ser Cys Gly His Val  Ser Glu Gly Lys Arg  Arg Phe Thr 
    1295                 1300                 1305             


Tyr Asp  His Ala Glu Leu Glu  Arg Lys Ile Ala Cys  Cys Ser Pro 
    1310                 1315                 1320             


Pro Pro  Asp Tyr Asn Ser Val  Val Leu Tyr Ser Thr  Pro Pro Ile 
    1325                 1330                 1335             


<210>  5460
<211>  541
<212>  PRT
<213>  Homo Sapiens

<400>  5460

Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro 
            20                  25                  30          


Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr 
        35                  40                  45              


Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro 
    50                  55                  60                  


Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala 
65                  70                  75                  80  


Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr 
                85                  90                  95      


Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val 
            100                 105                 110         


Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile 
        115                 120                 125             


Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
    130                 135                 140                 


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
145                 150                 155                 160 


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
                165                 170                 175     


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
            180                 185                 190         


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
        195                 200                 205             


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
    210                 215                 220                 


Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val 
225                 230                 235                 240 


Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr 
                245                 250                 255     


Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys 
            260                 265                 270         


Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His 
        275                 280                 285             


Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys 
    290                 295                 300                 


Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys 
305                 310                 315                 320 


Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys Ala Phe Ile Thr Val 
                325                 330                 335     


Lys His Arg Lys Gln Gln Val Leu Glu Thr Val Ala Gly Lys Arg Ser 
            340                 345                 350         


Tyr Arg Leu Ser Met Lys Val Lys Ala Phe Pro Ser Pro Glu Val Val 
        355                 360                 365             


Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu Lys Ser Ala Arg Tyr Leu 
    370                 375                 380                 


Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp Val Thr Glu Glu Asp Ala 
385                 390                 395                 400 


Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys Gln Ser Asn Val Phe Lys 
                405                 410                 415     


Asn Leu Thr Ala Thr Leu Ile Val Asn Val Lys Pro Gln Ile Tyr Glu 
            420                 425                 430         


Lys Ala Val Ser Ser Phe Pro Asp Pro Ala Leu Tyr Pro Leu Gly Ser 
        435                 440                 445             


Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly Ile Pro Gln Pro Thr Ile 
    450                 455                 460                 


Lys Trp Phe Trp His Pro Cys Asn His Asn His Ser Glu Ala Arg Cys 
465                 470                 475                 480 


Asp Phe Cys Ser Asn Asn Glu Glu Ser Phe Ile Leu Asp Ala Asp Ser 
                485                 490                 495     


Asn Met Gly Asn Arg Ile Glu Ser Ile Thr Gln Arg Met Ala Ile Ile 
            500                 505                 510         


Glu Gly Lys Asn Lys Leu Pro Pro Ala Asn Ser Ser Phe Met Leu Pro 
        515                 520                 525             


Pro Thr Ser Phe Ser Ser Asn Tyr Phe His Phe Leu Pro 
    530                 535                 540     


<210>  5461
<211>  733
<212>  PRT
<213>  Homo Sapiens

<400>  5461

Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro 
            20                  25                  30          


Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr 
        35                  40                  45              


Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro 
    50                  55                  60                  


Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala 
65                  70                  75                  80  


Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr 
                85                  90                  95      


Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val 
            100                 105                 110         


Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile 
        115                 120                 125             


Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
    130                 135                 140                 


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
145                 150                 155                 160 


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
                165                 170                 175     


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
            180                 185                 190         


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
        195                 200                 205             


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
    210                 215                 220                 


Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val 
225                 230                 235                 240 


Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr 
                245                 250                 255     


Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys 
            260                 265                 270         


Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His 
        275                 280                 285             


Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys 
    290                 295                 300                 


Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys 
305                 310                 315                 320 


Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys Ala Phe Ile Thr Val 
                325                 330                 335     


Lys His Arg Lys Gln Gln Val Leu Glu Thr Val Ala Gly Lys Arg Ser 
            340                 345                 350         


Tyr Arg Leu Ser Met Lys Val Lys Ala Phe Pro Ser Pro Glu Val Val 
        355                 360                 365             


Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu Lys Ser Ala Arg Tyr Leu 
    370                 375                 380                 


Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp Val Thr Glu Glu Asp Ala 
385                 390                 395                 400 


Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys Gln Ser Asn Val Phe Lys 
                405                 410                 415     


Asn Leu Thr Ala Thr Leu Ile Val Asn Val Lys Pro Gln Ile Tyr Glu 
            420                 425                 430         


Lys Ala Val Ser Ser Phe Pro Asp Pro Ala Leu Tyr Pro Leu Gly Ser 
        435                 440                 445             


Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly Ile Pro Gln Pro Thr Ile 
    450                 455                 460                 


Lys Trp Phe Trp His Pro Cys Asn His Asn His Ser Glu Ala Arg Cys 
465                 470                 475                 480 


Asp Phe Cys Ser Asn Asn Glu Glu Ser Phe Ile Leu Asp Ala Asp Ser 
                485                 490                 495     


Asn Met Gly Asn Arg Ile Glu Ser Ile Thr Gln Arg Met Ala Ile Ile 
            500                 505                 510         


Glu Gly Lys Asn Lys Met Ala Ser Thr Leu Val Val Ala Asp Ser Arg 
        515                 520                 525             


Ile Ser Gly Ile Tyr Ile Cys Ile Ala Ser Asn Lys Val Gly Thr Val 
    530                 535                 540                 


Gly Arg Asn Ile Ser Phe Tyr Ile Thr Asp Val Pro Asn Gly Phe His 
545                 550                 555                 560 


Val Asn Leu Glu Lys Met Pro Thr Glu Gly Glu Asp Leu Lys Leu Ser 
                565                 570                 575     


Cys Thr Val Asn Lys Phe Leu Tyr Arg Asp Val Thr Trp Ile Leu Leu 
            580                 585                 590         


Arg Thr Val Asn Asn Arg Thr Met His Tyr Ser Ile Ser Lys Gln Lys 
        595                 600                 605             


Met Ala Ile Thr Lys Glu His Ser Ile Thr Leu Asn Leu Thr Ile Met 
    610                 615                 620                 


Asn Val Ser Leu Gln Asp Ser Gly Thr Tyr Ala Cys Arg Ala Arg Asn 
625                 630                 635                 640 


Val Tyr Thr Gly Glu Glu Ile Leu Gln Lys Lys Glu Ile Thr Ile Arg 
                645                 650                 655     


Asp Gln Glu Ala Pro Tyr Leu Leu Arg Asn Leu Ser Asp His Thr Val 
            660                 665                 670         


Ala Ile Ser Ser Ser Thr Thr Leu Asp Cys His Ala Asn Gly Val Pro 
        675                 680                 685             


Glu Pro Gln Ile Thr Trp Phe Lys Asn Asn His Lys Ile Gln Gln Glu 
    690                 695                 700                 


Pro Glu Leu Tyr Thr Ser Thr Ser Pro Ser Ser Ser Ser Ser Ser Pro 
705                 710                 715                 720 


Leu Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
                725                 730             


<210>  5462
<211>  687
<212>  PRT
<213>  Homo Sapiens

<400>  5462

Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro 
            20                  25                  30          


Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr 
        35                  40                  45              


Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro 
    50                  55                  60                  


Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala 
65                  70                  75                  80  


Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr 
                85                  90                  95      


Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val 
            100                 105                 110         


Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile 
        115                 120                 125             


Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
    130                 135                 140                 


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
145                 150                 155                 160 


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
                165                 170                 175     


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
            180                 185                 190         


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
        195                 200                 205             


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
    210                 215                 220                 


Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val 
225                 230                 235                 240 


Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr 
                245                 250                 255     


Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys 
            260                 265                 270         


Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His 
        275                 280                 285             


Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys 
    290                 295                 300                 


Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys 
305                 310                 315                 320 


Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys Ala Phe Ile Thr Val 
                325                 330                 335     


Lys His Arg Lys Gln Gln Val Leu Glu Thr Val Ala Gly Lys Arg Ser 
            340                 345                 350         


Tyr Arg Leu Ser Met Lys Val Lys Ala Phe Pro Ser Pro Glu Val Val 
        355                 360                 365             


Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu Lys Ser Ala Arg Tyr Leu 
    370                 375                 380                 


Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp Val Thr Glu Glu Asp Ala 
385                 390                 395                 400 


Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys Gln Ser Asn Val Phe Lys 
                405                 410                 415     


Asn Leu Thr Ala Thr Leu Ile Val Asn Val Lys Pro Gln Ile Tyr Glu 
            420                 425                 430         


Lys Ala Val Ser Ser Phe Pro Asp Pro Ala Leu Tyr Pro Leu Gly Ser 
        435                 440                 445             


Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly Ile Pro Gln Pro Thr Ile 
    450                 455                 460                 


Lys Trp Phe Trp His Pro Cys Asn His Asn His Ser Glu Ala Arg Cys 
465                 470                 475                 480 


Asp Phe Cys Ser Asn Asn Glu Glu Ser Phe Ile Leu Asp Ala Asp Ser 
                485                 490                 495     


Asn Met Gly Asn Arg Ile Glu Ser Ile Thr Gln Arg Met Ala Ile Ile 
            500                 505                 510         


Glu Gly Lys Asn Lys Met Ala Ser Thr Leu Val Val Ala Asp Ser Arg 
        515                 520                 525             


Ile Ser Gly Ile Tyr Ile Cys Ile Ala Ser Asn Lys Val Gly Thr Val 
    530                 535                 540                 


Gly Arg Asn Ile Ser Phe Tyr Ile Thr Asp Val Pro Asn Gly Phe His 
545                 550                 555                 560 


Val Asn Leu Glu Lys Met Pro Thr Glu Gly Glu Asp Leu Lys Leu Ser 
                565                 570                 575     


Cys Thr Val Asn Lys Phe Leu Tyr Arg Asp Val Thr Trp Ile Leu Leu 
            580                 585                 590         


Arg Thr Val Asn Asn Arg Thr Met His Tyr Ser Ile Ser Lys Gln Lys 
        595                 600                 605             


Met Ala Ile Thr Lys Glu His Ser Ile Thr Leu Asn Leu Thr Ile Met 
    610                 615                 620                 


Asn Val Ser Leu Gln Asp Ser Gly Thr Tyr Ala Cys Arg Ala Arg Asn 
625                 630                 635                 640 


Val Tyr Thr Gly Glu Glu Ile Leu Gln Lys Lys Glu Ile Thr Ile Arg 
                645                 650                 655     


Gly Glu His Cys Asn Lys Lys Ala Val Phe Ser Arg Ile Ser Lys Phe 
            660                 665                 670         


Lys Ser Thr Arg Asn Asp Cys Thr Thr Gln Ser Asn Val Lys His 
        675                 680                 685         


<210>  5463
<211>  665
<212>  PRT
<213>  Homo Sapiens

<400>  5463

Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro 
            20                  25                  30          


Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr 
        35                  40                  45              


Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro 
    50                  55                  60                  


Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala 
65                  70                  75                  80  


Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr 
                85                  90                  95      


Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val 
            100                 105                 110         


Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile 
        115                 120                 125             


Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
    130                 135                 140                 


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
145                 150                 155                 160 


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
                165                 170                 175     


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
            180                 185                 190         


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
        195                 200                 205             


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
    210                 215                 220                 


Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val 
225                 230                 235                 240 


Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr 
                245                 250                 255     


Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys 
            260                 265                 270         


Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His 
        275                 280                 285             


Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys 
    290                 295                 300                 


Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys 
305                 310                 315                 320 


Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys Ala Phe Ile Thr Val 
                325                 330                 335     


Lys His Arg Lys Gln Gln Val Leu Glu Thr Val Ala Gly Lys Arg Ser 
            340                 345                 350         


Tyr Arg Leu Ser Met Lys Val Lys Ala Phe Pro Ser Pro Glu Val Val 
        355                 360                 365             


Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu Lys Ser Ala Arg Tyr Leu 
    370                 375                 380                 


Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp Val Thr Glu Glu Asp Ala 
385                 390                 395                 400 


Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys Gln Ser Asn Val Phe Lys 
                405                 410                 415     


Asn Leu Thr Ala Thr Leu Ile Val Asn Val Lys Pro Gln Ile Tyr Glu 
            420                 425                 430         


Lys Ala Val Ser Ser Phe Pro Asp Pro Ala Leu Tyr Pro Leu Gly Ser 
        435                 440                 445             


Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly Ile Pro Gln Pro Thr Ile 
    450                 455                 460                 


Lys Trp Phe Trp His Pro Cys Asn His Asn His Ser Glu Ala Arg Cys 
465                 470                 475                 480 


Asp Phe Cys Ser Asn Asn Glu Glu Ser Phe Ile Leu Asp Ala Asp Ser 
                485                 490                 495     


Asn Met Gly Asn Arg Ile Glu Ser Ile Thr Gln Arg Met Ala Ile Ile 
            500                 505                 510         


Glu Gly Lys Asn Lys Met Ala Ser Thr Leu Val Val Ala Asp Ser Arg 
        515                 520                 525             


Ile Ser Gly Ile Tyr Ile Cys Ile Ala Ser Asn Lys Val Gly Thr Val 
    530                 535                 540                 


Gly Arg Asn Ile Ser Phe Tyr Ile Thr Asp Val Pro Asn Gly Phe His 
545                 550                 555                 560 


Val Asn Leu Glu Lys Met Pro Thr Glu Gly Glu Asp Leu Lys Leu Ser 
                565                 570                 575     


Cys Thr Val Asn Lys Phe Leu Tyr Arg Asp Val Thr Trp Ile Leu Leu 
            580                 585                 590         


Arg Thr Val Asn Asn Arg Thr Met His Tyr Ser Ile Ser Lys Gln Lys 
        595                 600                 605             


Met Ala Ile Thr Lys Glu His Ser Ile Thr Leu Asn Leu Thr Ile Met 
    610                 615                 620                 


Asn Val Ser Leu Gln Asp Ser Gly Thr Tyr Ala Cys Arg Ala Arg Asn 
625                 630                 635                 640 


Val Tyr Thr Gly Glu Glu Ile Leu Gln Lys Lys Glu Ile Thr Ile Arg 
                645                 650                 655     


Gly Ser Glu Glu Met Leu Leu Pro Lys 
            660                 665 


<210>  5464
<211>  1363
<212>  PRT
<213>  Homo Sapiens

<400>  5464

Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu Trp Leu Cys Leu Gly 
1               5                   10                  15      


Leu Leu Asp Gly Leu Val Ser Gly Tyr Ser Met Thr Pro Pro Thr Leu 
            20                  25                  30          


Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr Gly Asp Ser Leu Ser 
        35                  40                  45              


Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp Ala Trp Pro Gly Ala 
    50                  55                  60                  


Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser Glu Asp Thr Gly Val 
65                  70                  75                  80  


Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro Tyr Cys Lys Val Leu 
                85                  90                  95      


Leu Leu His Glu Val His Ala Asn Asp Thr Gly Ser Tyr Val Cys Tyr 
            100                 105                 110         


Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr Thr Ala Ala Ser Ser 
        115                 120                 125             


Tyr Val Phe Val Arg Asp Phe Glu Gln Pro Phe Ile Asn Lys Pro Asp 
    130                 135                 140                 


Thr Leu Leu Val Asn Arg Lys Asp Ala Met Trp Val Pro Cys Leu Val 
145                 150                 155                 160 


Ser Ile Pro Gly Leu Asn Val Thr Leu Arg Ser Gln Ser Ser Val Leu 
                165                 170                 175     


Trp Pro Asp Gly Gln Glu Val Val Trp Asp Asp Arg Arg Gly Met Leu 
            180                 185                 190         


Val Ser Thr Pro Leu Leu His Asp Ala Leu Tyr Leu Gln Cys Glu Thr 
        195                 200                 205             


Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn Pro Phe Leu Val His Ile 
    210                 215                 220                 


Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu Leu Pro Arg Lys Ser Leu 
225                 230                 235                 240 


Glu Leu Leu Val Gly Glu Lys Leu Val Leu Asn Cys Thr Val Trp Ala 
                245                 250                 255     


Glu Phe Asn Ser Gly Val Thr Phe Asp Trp Asp Tyr Pro Gly Lys Gln 
            260                 265                 270         


Ala Glu Arg Gly Lys Trp Val Pro Glu Arg Arg Ser Gln Gln Thr His 
        275                 280                 285             


Thr Glu Leu Ser Ser Ile Leu Thr Ile His Asn Val Ser Gln His Asp 
    290                 295                 300                 


Leu Gly Ser Tyr Val Cys Lys Ala Asn Asn Gly Ile Gln Arg Phe Arg 
305                 310                 315                 320 


Glu Ser Thr Glu Val Ile Val His Glu Asn Pro Phe Ile Ser Val Glu 
                325                 330                 335     


Trp Leu Lys Gly Pro Ile Leu Glu Ala Thr Ala Gly Asp Glu Leu Val 
            340                 345                 350         


Lys Leu Pro Val Lys Leu Ala Ala Tyr Pro Pro Pro Glu Phe Gln Trp 
        355                 360                 365             


Tyr Lys Asp Gly Lys Ala Leu Ser Gly Arg His Ser Pro His Ala Leu 
    370                 375                 380                 


Val Leu Lys Glu Val Thr Glu Ala Ser Thr Gly Thr Tyr Thr Leu Ala 
385                 390                 395                 400 


Leu Trp Asn Ser Ala Ala Gly Leu Arg Arg Asn Ile Ser Leu Glu Leu 
                405                 410                 415     


Val Val Asn Val Pro Pro Gln Ile His Glu Lys Glu Ala Ser Ser Pro 
            420                 425                 430         


Ser Ile Tyr Ser Arg His Ser Arg Gln Ala Leu Thr Cys Thr Ala Tyr 
        435                 440                 445             


Gly Val Pro Leu Pro Leu Ser Ile Gln Trp His Trp Arg Pro Trp Thr 
    450                 455                 460                 


Pro Cys Lys Met Phe Ala Gln Arg Ser Leu Arg Arg Arg Gln Gln Gln 
465                 470                 475                 480 


Asp Leu Met Pro Gln Cys Arg Asp Trp Arg Ala Val Thr Thr Gln Asp 
                485                 490                 495     


Ala Val Asn Pro Ile Glu Ser Leu Asp Thr Trp Thr Glu Phe Val Glu 
            500                 505                 510         


Gly Lys Asn Lys Thr Val Ser Lys Leu Val Ile Gln Asn Ala Asn Val 
        515                 520                 525             


Ser Ala Met Tyr Lys Cys Val Val Ser Asn Lys Val Gly Gln Asp Glu 
    530                 535                 540                 


Arg Leu Ile Tyr Phe Tyr Val Thr Thr Ile Pro Asp Gly Phe Thr Ile 
545                 550                 555                 560 


Glu Ser Lys Pro Ser Glu Glu Leu Leu Glu Gly Gln Pro Val Leu Leu 
                565                 570                 575     


Ser Cys Gln Ala Asp Ser Tyr Lys Tyr Glu His Leu Arg Trp Tyr Arg 
            580                 585                 590         


Leu Asn Leu Ser Thr Leu His Asp Ala His Gly Asn Pro Leu Leu Leu 
        595                 600                 605             


Asp Cys Lys Asn Val His Leu Phe Ala Thr Pro Leu Ala Ala Ser Leu 
    610                 615                 620                 


Glu Glu Val Ala Pro Gly Ala Arg His Ala Thr Leu Ser Leu Ser Ile 
625                 630                 635                 640 


Pro Arg Val Ala Pro Glu His Glu Gly His Tyr Val Cys Glu Val Gln 
                645                 650                 655     


Asp Arg Arg Ser His Asp Lys His Cys His Lys Lys Tyr Leu Ser Val 
            660                 665                 670         


Gln Ala Leu Glu Ala Pro Arg Leu Thr Gln Asn Leu Thr Asp Leu Leu 
        675                 680                 685             


Val Asn Val Ser Asp Ser Leu Glu Met Gln Cys Leu Val Ala Gly Ala 
    690                 695                 700                 


His Ala Pro Ser Ile Val Trp Tyr Lys Asp Glu Arg Leu Leu Glu Glu 
705                 710                 715                 720 


Lys Ser Gly Val Asp Leu Ala Asp Ser Asn Gln Lys Leu Ser Ile Gln 
                725                 730                 735     


Arg Val Arg Glu Glu Asp Ala Gly Arg Tyr Leu Cys Ser Val Cys Asn 
            740                 745                 750         


Ala Lys Gly Cys Val Asn Ser Ser Ala Ser Val Ala Val Glu Gly Ser 
        755                 760                 765             


Glu Asp Lys Gly Ser Met Glu Ile Val Ile Leu Val Gly Thr Gly Val 
    770                 775                 780                 


Ile Ala Val Phe Phe Trp Val Leu Leu Leu Leu Ile Phe Cys Asn Met 
785                 790                 795                 800 


Arg Arg Pro Ala His Ala Asp Ile Lys Thr Gly Tyr Leu Ser Ile Ile 
                805                 810                 815     


Met Asp Pro Gly Glu Val Pro Leu Glu Glu Gln Cys Glu Tyr Leu Ser 
            820                 825                 830         


Tyr Asp Ala Ser Gln Trp Glu Phe Pro Arg Glu Arg Leu His Leu Gly 
        835                 840                 845             


Arg Val Leu Gly Tyr Gly Ala Phe Gly Lys Val Val Glu Ala Ser Ala 
    850                 855                 860                 


Phe Gly Ile His Lys Gly Ser Ser Cys Asp Thr Val Ala Val Lys Met 
865                 870                 875                 880 


Leu Lys Glu Gly Ala Thr Ala Ser Glu His Arg Ala Leu Met Ser Glu 
                885                 890                 895     


Leu Lys Ile Leu Ile His Ile Gly Asn His Leu Asn Val Val Asn Leu 
            900                 905                 910         


Leu Gly Ala Cys Thr Lys Pro Gln Gly Pro Leu Met Val Ile Val Glu 
        915                 920                 925             


Phe Cys Lys Tyr Gly Asn Leu Ser Asn Phe Leu Arg Ala Lys Arg Asp 
    930                 935                 940                 


Ala Phe Ser Pro Cys Ala Glu Lys Ser Pro Glu Gln Arg Gly Arg Phe 
945                 950                 955                 960 


Arg Ala Met Val Glu Leu Ala Arg Leu Asp Arg Arg Arg Pro Gly Ser 
                965                 970                 975     


Ser Asp Arg Val Leu Phe Ala Arg Phe Ser Lys Thr Glu Gly Gly Ala 
            980                 985                 990         


Arg Arg Ala Ser Pro Asp Gln Glu  Ala Glu Asp Leu Trp  Leu Ser Pro 
        995                 1000                 1005             


Leu Thr  Met Glu Asp Leu Val  Cys Tyr Ser Phe Gln  Val Ala Arg 
    1010                 1015                 1020             


Gly Met  Glu Phe Leu Ala Ser  Arg Lys Cys Ile His  Arg Asp Leu 
    1025                 1030                 1035             


Ala Ala  Arg Asn Ile Leu Leu  Ser Glu Ser Asp Val  Val Lys Ile 
    1040                 1045                 1050             


Cys Asp  Phe Gly Leu Ala Arg  Asp Ile Tyr Lys Asp  Pro Asp Tyr 
    1055                 1060                 1065             


Val Arg  Lys Gly Ser Ala Arg  Leu Pro Leu Lys Trp  Met Ala Pro 
    1070                 1075                 1080             


Glu Ser  Ile Phe Asp Lys Val  Tyr Thr Thr Gln Ser  Asp Val Trp 
    1085                 1090                 1095             


Ser Phe  Gly Val Leu Leu Trp  Glu Ile Phe Ser Leu  Gly Ala Ser 
    1100                 1105                 1110             


Pro Tyr  Pro Gly Val Gln Ile  Asn Glu Glu Phe Cys  Gln Arg Leu 
    1115                 1120                 1125             


Arg Asp  Gly Thr Arg Met Arg  Ala Pro Glu Leu Ala  Thr Pro Ala 
    1130                 1135                 1140             


Ile Arg  Arg Ile Met Leu Asn  Cys Trp Ser Gly Asp  Pro Lys Ala 
    1145                 1150                 1155             


Arg Pro  Ala Phe Ser Glu Leu  Val Glu Ile Leu Gly  Asp Leu Leu 
    1160                 1165                 1170             


Gln Gly  Arg Gly Leu Gln Glu  Glu Glu Glu Val Cys  Met Ala Pro 
    1175                 1180                 1185             


Arg Ser  Ser Gln Ser Ser Glu  Glu Gly Ser Phe Ser  Gln Val Ser 
    1190                 1195                 1200             


Thr Met  Ala Leu His Ile Ala  Gln Ala Asp Ala Glu  Asp Ser Pro 
    1205                 1210                 1215             


Pro Ser  Leu Gln Arg His Ser  Leu Ala Ala Arg Tyr  Tyr Asn Trp 
    1220                 1225                 1230             


Val Ser  Phe Pro Gly Cys Leu  Ala Arg Gly Ala Glu  Thr Arg Gly 
    1235                 1240                 1245             


Ser Ser  Arg Met Lys Thr Phe  Glu Glu Phe Pro Met  Thr Pro Thr 
    1250                 1255                 1260             


Thr Tyr  Lys Gly Ser Val Asp  Asn Gln Thr Asp Ser  Gly Met Val 
    1265                 1270                 1275             


Leu Ala  Ser Glu Glu Phe Glu  Gln Ile Glu Ser Arg  His Arg Gln 
    1280                 1285                 1290             


Glu Ser  Gly Phe Ser Cys Lys  Gly Pro Gly Gln Asn  Val Ala Val 
    1295                 1300                 1305             


Thr Arg  Ala His Pro Asp Ser  Gln Gly Arg Arg Arg  Arg Pro Glu 
    1310                 1315                 1320             


Arg Gly  Ala Arg Gly Gly Gln  Val Phe Tyr Asn Ser  Glu Tyr Gly 
    1325                 1330                 1335             


Glu Leu  Ser Glu Pro Ser Glu  Glu Asp His Cys Ser  Pro Ser Ala 
    1340                 1345                 1350             


Arg Val  Thr Phe Phe Thr Asp  Asn Ser Tyr 
    1355                 1360             


<210>  5465
<211>  1298
<212>  PRT
<213>  Homo Sapiens

<400>  5465

Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu Trp Leu Cys Leu Gly 
1               5                   10                  15      


Leu Leu Asp Gly Leu Val Ser Gly Tyr Ser Met Thr Pro Pro Thr Leu 
            20                  25                  30          


Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr Gly Asp Ser Leu Ser 
        35                  40                  45              


Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp Ala Trp Pro Gly Ala 
    50                  55                  60                  


Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser Glu Asp Thr Gly Val 
65                  70                  75                  80  


Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro Tyr Cys Lys Val Leu 
                85                  90                  95      


Leu Leu His Glu Val His Ala Asn Asp Thr Gly Ser Tyr Val Cys Tyr 
            100                 105                 110         


Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr Thr Ala Ala Ser Ser 
        115                 120                 125             


Tyr Val Phe Val Arg Asp Phe Glu Gln Pro Phe Ile Asn Lys Pro Asp 
    130                 135                 140                 


Thr Leu Leu Val Asn Arg Lys Asp Ala Met Trp Val Pro Cys Leu Val 
145                 150                 155                 160 


Ser Ile Pro Gly Leu Asn Val Thr Leu Arg Ser Gln Ser Ser Val Leu 
                165                 170                 175     


Trp Pro Asp Gly Gln Glu Val Val Trp Asp Asp Arg Arg Gly Met Leu 
            180                 185                 190         


Val Ser Thr Pro Leu Leu His Asp Ala Leu Tyr Leu Gln Cys Glu Thr 
        195                 200                 205             


Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn Pro Phe Leu Val His Ile 
    210                 215                 220                 


Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu Leu Pro Arg Lys Ser Leu 
225                 230                 235                 240 


Glu Leu Leu Val Gly Glu Lys Leu Val Leu Asn Cys Thr Val Trp Ala 
                245                 250                 255     


Glu Phe Asn Ser Gly Val Thr Phe Asp Trp Asp Tyr Pro Gly Lys Gln 
            260                 265                 270         


Ala Glu Arg Gly Lys Trp Val Pro Glu Arg Arg Ser Gln Gln Thr His 
        275                 280                 285             


Thr Glu Leu Ser Ser Ile Leu Thr Ile His Asn Val Ser Gln His Asp 
    290                 295                 300                 


Leu Gly Ser Tyr Val Cys Lys Ala Asn Asn Gly Ile Gln Arg Phe Arg 
305                 310                 315                 320 


Glu Ser Thr Glu Val Ile Val His Glu Asn Pro Phe Ile Ser Val Glu 
                325                 330                 335     


Trp Leu Lys Gly Pro Ile Leu Glu Ala Thr Ala Gly Asp Glu Leu Val 
            340                 345                 350         


Lys Leu Pro Val Lys Leu Ala Ala Tyr Pro Pro Pro Glu Phe Gln Trp 
        355                 360                 365             


Tyr Lys Asp Gly Lys Ala Leu Ser Gly Arg His Ser Pro His Ala Leu 
    370                 375                 380                 


Val Leu Lys Glu Val Thr Glu Ala Ser Thr Gly Thr Tyr Thr Leu Ala 
385                 390                 395                 400 


Leu Trp Asn Ser Ala Ala Gly Leu Arg Arg Asn Ile Ser Leu Glu Leu 
                405                 410                 415     


Val Val Asn Val Pro Pro Gln Ile His Glu Lys Glu Ala Ser Ser Pro 
            420                 425                 430         


Ser Ile Tyr Ser Arg His Ser Arg Gln Ala Leu Thr Cys Thr Ala Tyr 
        435                 440                 445             


Gly Val Pro Leu Pro Leu Ser Ile Gln Trp His Trp Arg Pro Trp Thr 
    450                 455                 460                 


Pro Cys Lys Met Phe Ala Gln Arg Ser Leu Arg Arg Arg Gln Gln Gln 
465                 470                 475                 480 


Asp Leu Met Pro Gln Cys Arg Asp Trp Arg Ala Val Thr Thr Gln Asp 
                485                 490                 495     


Ala Val Asn Pro Ile Glu Ser Leu Asp Thr Trp Thr Glu Phe Val Glu 
            500                 505                 510         


Gly Lys Asn Lys Thr Val Ser Lys Leu Val Ile Gln Asn Ala Asn Val 
        515                 520                 525             


Ser Ala Met Tyr Lys Cys Val Val Ser Asn Lys Val Gly Gln Asp Glu 
    530                 535                 540                 


Arg Leu Ile Tyr Phe Tyr Val Thr Thr Ile Pro Asp Gly Phe Thr Ile 
545                 550                 555                 560 


Glu Ser Lys Pro Ser Glu Glu Leu Leu Glu Gly Gln Pro Val Leu Leu 
                565                 570                 575     


Ser Cys Gln Ala Asp Ser Tyr Lys Tyr Glu His Leu Arg Trp Tyr Arg 
            580                 585                 590         


Leu Asn Leu Ser Thr Leu His Asp Ala His Gly Asn Pro Leu Leu Leu 
        595                 600                 605             


Asp Cys Lys Asn Val His Leu Phe Ala Thr Pro Leu Ala Ala Ser Leu 
    610                 615                 620                 


Glu Glu Val Ala Pro Gly Ala Arg His Ala Thr Leu Ser Leu Ser Ile 
625                 630                 635                 640 


Pro Arg Val Ala Pro Glu His Glu Gly His Tyr Val Cys Glu Val Gln 
                645                 650                 655     


Asp Arg Arg Ser His Asp Lys His Cys His Lys Lys Tyr Leu Ser Val 
            660                 665                 670         


Gln Ala Leu Glu Ala Pro Arg Leu Thr Gln Asn Leu Thr Asp Leu Leu 
        675                 680                 685             


Val Asn Val Ser Asp Ser Leu Glu Met Gln Cys Leu Val Ala Gly Ala 
    690                 695                 700                 


His Ala Pro Ser Ile Val Trp Tyr Lys Asp Glu Arg Leu Leu Glu Glu 
705                 710                 715                 720 


Lys Ser Gly Val Asp Leu Ala Asp Ser Asn Gln Lys Leu Ser Ile Gln 
                725                 730                 735     


Arg Val Arg Glu Glu Asp Ala Gly Arg Tyr Leu Cys Ser Val Cys Asn 
            740                 745                 750         


Ala Lys Gly Cys Val Asn Ser Ser Ala Ser Val Ala Val Glu Gly Ser 
        755                 760                 765             


Glu Asp Lys Gly Ser Met Glu Ile Val Ile Leu Val Gly Thr Gly Val 
    770                 775                 780                 


Ile Ala Val Phe Phe Trp Val Leu Leu Leu Leu Ile Phe Cys Asn Met 
785                 790                 795                 800 


Arg Arg Pro Ala His Ala Asp Ile Lys Thr Gly Tyr Leu Ser Ile Ile 
                805                 810                 815     


Met Asp Pro Gly Glu Val Pro Leu Glu Glu Gln Cys Glu Tyr Leu Ser 
            820                 825                 830         


Tyr Asp Ala Ser Gln Trp Glu Phe Pro Arg Glu Arg Leu His Leu Gly 
        835                 840                 845             


Arg Val Leu Gly Tyr Gly Ala Phe Gly Lys Val Val Glu Ala Ser Ala 
    850                 855                 860                 


Phe Gly Ile His Lys Gly Ser Ser Cys Asp Thr Val Ala Val Lys Met 
865                 870                 875                 880 


Leu Lys Glu Gly Ala Thr Ala Ser Glu His Arg Ala Leu Met Ser Glu 
                885                 890                 895     


Leu Lys Ile Leu Ile His Ile Gly Asn His Leu Asn Val Val Asn Leu 
            900                 905                 910         


Leu Gly Ala Cys Thr Lys Pro Gln Gly Pro Leu Met Val Ile Val Glu 
        915                 920                 925             


Phe Cys Lys Tyr Gly Asn Leu Ser Asn Phe Leu Arg Ala Lys Arg Asp 
    930                 935                 940                 


Ala Phe Ser Pro Cys Ala Glu Lys Ser Pro Glu Gln Arg Gly Arg Phe 
945                 950                 955                 960 


Arg Ala Met Val Glu Leu Ala Arg Leu Asp Arg Arg Arg Pro Gly Ser 
                965                 970                 975     


Ser Asp Arg Val Leu Phe Ala Arg Phe Ser Lys Thr Glu Gly Gly Ala 
            980                 985                 990         


Arg Arg Ala Ser Pro Asp Gln Glu  Ala Glu Asp Leu Trp  Leu Ser Pro 
        995                 1000                 1005             


Leu Thr  Met Glu Asp Leu Val  Cys Tyr Ser Phe Gln  Val Ala Arg 
    1010                 1015                 1020             


Gly Met  Glu Phe Leu Ala Ser  Arg Lys Cys Ile His  Arg Asp Leu 
    1025                 1030                 1035             


Ala Ala  Arg Asn Ile Leu Leu  Ser Glu Ser Asp Val  Val Lys Ile 
    1040                 1045                 1050             


Cys Asp  Phe Gly Leu Ala Arg  Asp Ile Tyr Lys Asp  Pro Asp Tyr 
    1055                 1060                 1065             


Val Arg  Lys Gly Ser Ala Arg  Leu Pro Leu Lys Trp  Met Ala Pro 
    1070                 1075                 1080             


Glu Ser  Ile Phe Asp Lys Val  Tyr Thr Thr Gln Ser  Asp Val Trp 
    1085                 1090                 1095             


Ser Phe  Gly Val Leu Leu Trp  Glu Ile Phe Ser Leu  Gly Ala Ser 
    1100                 1105                 1110             


Pro Tyr  Pro Gly Val Gln Ile  Asn Glu Glu Phe Cys  Gln Arg Leu 
    1115                 1120                 1125             


Arg Asp  Gly Thr Arg Met Arg  Ala Pro Glu Leu Ala  Thr Pro Ala 
    1130                 1135                 1140             


Ile Arg  Arg Ile Met Leu Asn  Cys Trp Ser Gly Asp  Pro Lys Ala 
    1145                 1150                 1155             


Arg Pro  Ala Phe Ser Glu Leu  Val Glu Ile Leu Gly  Asp Leu Leu 
    1160                 1165                 1170             


Gln Gly  Arg Gly Leu Gln Glu  Glu Glu Glu Val Cys  Met Ala Pro 
    1175                 1180                 1185             


Arg Ser  Ser Gln Ser Ser Glu  Glu Gly Ser Phe Ser  Gln Val Ser 
    1190                 1195                 1200             


Thr Met  Ala Leu His Ile Ala  Gln Ala Asp Ala Glu  Asp Ser Pro 
    1205                 1210                 1215             


Pro Ser  Leu Gln Arg His Ser  Leu Ala Ala Arg Tyr  Tyr Asn Trp 
    1220                 1225                 1230             


Val Ser  Phe Pro Gly Cys Leu  Ala Arg Gly Ala Glu  Thr Arg Gly 
    1235                 1240                 1245             


Ser Ser  Arg Met Lys Thr Phe  Glu Glu Phe Pro Met  Thr Pro Thr 
    1250                 1255                 1260             


Thr Tyr  Lys Gly Ser Val Asp  Asn Gln Thr Asp Ser  Gly Met Val 
    1265                 1270                 1275             


Leu Ala  Ser Glu Glu Phe Glu  Gln Ile Glu Ser Arg  His Arg Gln 
    1280                 1285                 1290             


Glu Ser  Gly Phe Arg 
    1295             


<210>  5466
<211>  1306
<212>  PRT
<213>  Homo Sapiens

<400>  5466

Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu Trp Leu Cys Leu Gly 
1               5                   10                  15      


Leu Leu Asp Gly Leu Val Ser Gly Tyr Ser Met Thr Pro Pro Thr Leu 
            20                  25                  30          


Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr Gly Asp Ser Leu Ser 
        35                  40                  45              


Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp Ala Trp Pro Gly Ala 
    50                  55                  60                  


Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser Glu Asp Thr Gly Val 
65                  70                  75                  80  


Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro Tyr Cys Lys Val Leu 
                85                  90                  95      


Leu Leu His Glu Val His Ala Asn Asp Thr Gly Ser Tyr Val Cys Tyr 
            100                 105                 110         


Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr Thr Ala Ala Ser Ser 
        115                 120                 125             


Tyr Val Phe Val Arg Asp Phe Glu Gln Pro Phe Ile Asn Lys Pro Asp 
    130                 135                 140                 


Thr Leu Leu Val Asn Arg Lys Asp Ala Met Trp Val Pro Cys Leu Val 
145                 150                 155                 160 


Ser Ile Pro Gly Leu Asn Val Thr Leu Arg Ser Gln Ser Ser Val Leu 
                165                 170                 175     


Trp Pro Asp Gly Gln Glu Val Val Trp Asp Asp Arg Arg Gly Met Leu 
            180                 185                 190         


Val Ser Thr Pro Leu Leu His Asp Ala Leu Tyr Leu Gln Cys Glu Thr 
        195                 200                 205             


Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn Pro Phe Leu Val His Ile 
    210                 215                 220                 


Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu Leu Pro Arg Lys Ser Leu 
225                 230                 235                 240 


Glu Leu Leu Val Gly Glu Lys Leu Val Leu Asn Cys Thr Val Trp Ala 
                245                 250                 255     


Glu Phe Asn Ser Gly Val Thr Phe Asp Trp Asp Tyr Pro Gly Lys Gln 
            260                 265                 270         


Ala Glu Arg Gly Lys Trp Val Pro Glu Arg Arg Ser Gln Gln Thr His 
        275                 280                 285             


Thr Glu Leu Ser Ser Ile Leu Thr Ile His Asn Val Ser Gln His Asp 
    290                 295                 300                 


Leu Gly Ser Tyr Val Cys Lys Ala Asn Asn Gly Ile Gln Arg Phe Arg 
305                 310                 315                 320 


Glu Ser Thr Glu Val Ile Val His Glu Asn Pro Phe Ile Ser Val Glu 
                325                 330                 335     


Trp Leu Lys Gly Pro Ile Leu Glu Ala Thr Ala Gly Asp Glu Leu Val 
            340                 345                 350         


Lys Leu Pro Val Lys Leu Ala Ala Tyr Pro Pro Pro Glu Phe Gln Trp 
        355                 360                 365             


Tyr Lys Asp Gly Lys Ala Leu Ser Gly Arg His Ser Pro His Ala Leu 
    370                 375                 380                 


Val Leu Lys Glu Val Thr Glu Ala Ser Thr Gly Thr Tyr Thr Leu Ala 
385                 390                 395                 400 


Leu Trp Asn Ser Ala Ala Gly Leu Arg Arg Asn Ile Ser Leu Glu Leu 
                405                 410                 415     


Val Val Asn Val Pro Pro Gln Ile His Glu Lys Glu Ala Ser Ser Pro 
            420                 425                 430         


Ser Ile Tyr Ser Arg His Ser Arg Gln Ala Leu Thr Cys Thr Ala Tyr 
        435                 440                 445             


Gly Val Pro Leu Pro Leu Ser Ile Gln Trp His Trp Arg Pro Trp Thr 
    450                 455                 460                 


Pro Cys Lys Met Phe Ala Gln Arg Ser Leu Arg Arg Arg Gln Gln Gln 
465                 470                 475                 480 


Asp Leu Met Pro Gln Cys Arg Asp Trp Arg Ala Val Thr Thr Gln Asp 
                485                 490                 495     


Ala Val Asn Pro Ile Glu Ser Leu Asp Thr Trp Thr Glu Phe Val Glu 
            500                 505                 510         


Gly Lys Asn Lys Thr Val Ser Lys Leu Val Ile Gln Asn Ala Asn Val 
        515                 520                 525             


Ser Ala Met Tyr Lys Cys Val Val Ser Asn Lys Val Gly Gln Asp Glu 
    530                 535                 540                 


Arg Leu Ile Tyr Phe Tyr Val Thr Thr Ile Pro Asp Gly Phe Thr Ile 
545                 550                 555                 560 


Glu Ser Lys Pro Ser Glu Glu Leu Leu Glu Gly Gln Pro Val Leu Leu 
                565                 570                 575     


Ser Cys Gln Ala Asp Ser Tyr Lys Tyr Glu His Leu Arg Trp Tyr Arg 
            580                 585                 590         


Leu Asn Leu Ser Thr Leu His Asp Ala His Gly Asn Pro Leu Leu Leu 
        595                 600                 605             


Asp Cys Lys Asn Val His Leu Phe Ala Thr Pro Leu Ala Ala Ser Leu 
    610                 615                 620                 


Glu Glu Val Ala Pro Gly Ala Arg His Ala Thr Leu Ser Leu Ser Ile 
625                 630                 635                 640 


Pro Arg Val Ala Pro Glu His Glu Gly His Tyr Val Cys Glu Val Gln 
                645                 650                 655     


Asp Arg Arg Ser His Asp Lys His Cys His Lys Lys Tyr Leu Ser Val 
            660                 665                 670         


Gln Ala Leu Glu Ala Pro Arg Leu Thr Gln Asn Leu Thr Asp Leu Leu 
        675                 680                 685             


Val Asn Val Ser Asp Ser Leu Glu Met Gln Cys Leu Val Ala Gly Ala 
    690                 695                 700                 


His Ala Pro Ser Ile Val Trp Tyr Lys Asp Glu Arg Leu Leu Glu Glu 
705                 710                 715                 720 


Lys Ser Gly Val Asp Leu Ala Asp Ser Asn Gln Lys Leu Ser Ile Gln 
                725                 730                 735     


Arg Val Arg Glu Glu Asp Ala Gly Arg Tyr Leu Cys Ser Val Cys Asn 
            740                 745                 750         


Ala Lys Gly Cys Val Asn Ser Ser Ala Ser Val Ala Val Glu Gly Ser 
        755                 760                 765             


Glu Asp Lys Gly Ser Met Glu Ile Val Ile Leu Val Gly Thr Gly Val 
    770                 775                 780                 


Ile Ala Val Phe Phe Trp Val Leu Leu Leu Leu Ile Phe Cys Asn Met 
785                 790                 795                 800 


Arg Arg Pro Ala His Ala Asp Ile Lys Thr Gly Tyr Leu Ser Ile Ile 
                805                 810                 815     


Met Asp Pro Gly Glu Val Pro Leu Glu Glu Gln Cys Glu Tyr Leu Ser 
            820                 825                 830         


Tyr Asp Ala Ser Gln Trp Glu Phe Pro Arg Glu Arg Leu His Leu Gly 
        835                 840                 845             


Arg Val Leu Gly Tyr Gly Ala Phe Gly Lys Val Val Glu Ala Ser Ala 
    850                 855                 860                 


Phe Gly Ile His Lys Gly Ser Ser Cys Asp Thr Val Ala Val Lys Met 
865                 870                 875                 880 


Leu Lys Glu Gly Ala Thr Ala Ser Glu His Arg Ala Leu Met Ser Glu 
                885                 890                 895     


Leu Lys Ile Leu Ile His Ile Gly Asn His Leu Asn Val Val Asn Leu 
            900                 905                 910         


Leu Gly Ala Cys Thr Lys Pro Gln Gly Pro Leu Met Val Ile Val Glu 
        915                 920                 925             


Phe Cys Lys Tyr Gly Asn Leu Ser Asn Phe Leu Arg Ala Lys Arg Asp 
    930                 935                 940                 


Ala Phe Ser Pro Cys Ala Glu Lys Ser Pro Glu Gln Arg Gly Arg Phe 
945                 950                 955                 960 


Arg Ala Met Val Glu Leu Ala Arg Leu Asp Arg Arg Arg Pro Gly Ser 
                965                 970                 975     


Ser Asp Arg Val Leu Phe Ala Arg Phe Ser Lys Thr Glu Gly Gly Ala 
            980                 985                 990         


Arg Arg Ala Ser Pro Asp Gln Glu  Ala Glu Asp Leu Trp  Leu Ser Pro 
        995                 1000                 1005             


Leu Thr  Met Glu Asp Leu Val  Cys Tyr Ser Phe Gln  Val Ala Arg 
    1010                 1015                 1020             


Gly Met  Glu Phe Leu Ala Ser  Arg Lys Cys Ile His  Arg Asp Leu 
    1025                 1030                 1035             


Ala Ala  Arg Asn Ile Leu Leu  Ser Glu Ser Asp Val  Val Lys Ile 
    1040                 1045                 1050             


Cys Asp  Phe Gly Leu Ala Arg  Asp Ile Tyr Lys Asp  Pro Asp Tyr 
    1055                 1060                 1065             


Val Arg  Lys Gly Ser Ala Arg  Leu Pro Leu Lys Trp  Met Ala Pro 
    1070                 1075                 1080             


Glu Ser  Ile Phe Asp Lys Val  Tyr Thr Thr Gln Ser  Asp Val Trp 
    1085                 1090                 1095             


Ser Phe  Gly Val Leu Leu Trp  Glu Ile Phe Ser Leu  Gly Ala Ser 
    1100                 1105                 1110             


Pro Tyr  Pro Gly Val Gln Ile  Asn Glu Glu Phe Cys  Gln Arg Leu 
    1115                 1120                 1125             


Arg Asp  Gly Thr Arg Met Arg  Ala Pro Glu Leu Ala  Thr Pro Ala 
    1130                 1135                 1140             


Ile Arg  Arg Ile Met Leu Asn  Cys Trp Ser Gly Asp  Pro Lys Ala 
    1145                 1150                 1155             


Arg Pro  Ala Phe Ser Glu Leu  Val Glu Ile Leu Gly  Asp Leu Leu 
    1160                 1165                 1170             


Gln Gly  Arg Gly Leu Gln Glu  Glu Glu Glu Val Cys  Met Ala Pro 
    1175                 1180                 1185             


Arg Ser  Ser Gln Ser Ser Glu  Glu Gly Ser Phe Ser  Gln Val Ser 
    1190                 1195                 1200             


Thr Met  Ala Leu His Ile Ala  Gln Ala Asp Ala Glu  Asp Ser Pro 
    1205                 1210                 1215             


Pro Ser  Leu Gln Arg His Ser  Leu Ala Ala Arg Tyr  Tyr Asn Trp 
    1220                 1225                 1230             


Val Ser  Phe Pro Gly Cys Leu  Ala Arg Gly Ala Glu  Thr Arg Gly 
    1235                 1240                 1245             


Ser Ser  Arg Met Lys Thr Phe  Glu Glu Phe Pro Met  Thr Pro Thr 
    1250                 1255                 1260             


Thr Tyr  Lys Gly Ser Val Asp  Asn Gln Thr Asp Ser  Gly Met Val 
    1265                 1270                 1275             


Leu Ala  Ser Glu Glu Phe Glu  Gln Ile Glu Ser Arg  His Arg Gln 
    1280                 1285                 1290             


Glu Ser  Gly Phe Arg Gly Thr  Arg Arg Thr Arg Gly  Ala 
    1295                 1300                 1305     


<210>  5467
<211>  295
<212>  PRT
<213>  Homo Sapiens

<400>  5467

Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu Trp Leu Cys Leu Gly 
1               5                   10                  15      


Leu Leu Asp Gly Leu Val Ser Gly Tyr Ser Met Thr Pro Pro Thr Leu 
            20                  25                  30          


Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr Gly Asp Ser Leu Ser 
        35                  40                  45              


Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp Ala Trp Pro Gly Ala 
    50                  55                  60                  


Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser Glu Asp Thr Gly Val 
65                  70                  75                  80  


Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro Tyr Cys Lys Val Leu 
                85                  90                  95      


Leu Leu His Glu Val His Ala Asn Asp Thr Gly Ser Tyr Val Cys Tyr 
            100                 105                 110         


Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr Thr Ala Ala Ser Ser 
        115                 120                 125             


Tyr Val Phe Val Arg Asp Phe Glu Gln Pro Phe Ile Asn Lys Pro Asp 
    130                 135                 140                 


Thr Leu Leu Val Asn Arg Lys Asp Ala Met Trp Val Pro Cys Leu Val 
145                 150                 155                 160 


Ser Ile Pro Gly Leu Asn Val Thr Leu Arg Ser Gln Ser Ser Val Leu 
                165                 170                 175     


Trp Pro Asp Gly Gln Glu Val Val Trp Asp Asp Arg Arg Gly Met Leu 
            180                 185                 190         


Val Ser Thr Pro Leu Leu His Asp Ala Leu Tyr Leu Gln Cys Glu Thr 
        195                 200                 205             


Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn Pro Phe Leu Val His Ile 
    210                 215                 220                 


Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu Leu Pro Arg Lys Ser Leu 
225                 230                 235                 240 


Glu Leu Leu Val Gly Glu Lys Leu Val Leu Asn Cys Thr Val Trp Ala 
                245                 250                 255     


Glu Phe Asn Ser Gly Val Thr Phe Asp Trp Asp Tyr Pro Gly Lys Gln 
            260                 265                 270         


Lys Ile Pro Ser Ser Ala Ser Ser Gly Ser Lys Asp Pro Ser Trp Arg 
        275                 280                 285             


Pro Arg Gln Glu Thr Ser Trp 
    290                 295 


<210>  5468
<211>  142
<212>  PRT
<213>  Homo Sapiens

<400>  5468

Met Val Glu Leu Ala Arg Leu Asp Arg Arg Arg Pro Gly Ser Ser Asp 
1               5                   10                  15      


Arg Val Leu Phe Ala Arg Phe Ser Lys Thr Glu Gly Gly Ala Arg Arg 
            20                  25                  30          


Ala Ser Pro Asp Gln Glu Ala Glu Asp Leu Trp Leu Ser Pro Leu Thr 
        35                  40                  45              


Met Glu Asp Leu Val Cys Tyr Ser Phe Gln Val Ala Arg Gly Met Glu 
    50                  55                  60                  


Phe Leu Ala Ser Arg Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn 
65                  70                  75                  80  


Ile Leu Leu Ser Glu Ser Asp Val Val Lys Ile Cys Asp Phe Gly Leu 
                85                  90                  95      


Ala Arg Asp Ile Tyr Lys Asp Pro Asp Tyr Val Arg Lys Gly Ser Ala 
            100                 105                 110         


Arg Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asp Lys Val 
        115                 120                 125             


Tyr Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu 
    130                 135                 140         


<210>  5469
<211>  126
<212>  PRT
<213>  Homo Sapiens

<400>  5469

Met Ala Lys Arg Val Ala Ile Val Gly Ala Gly Val Ser Gly Leu Ala 
1               5                   10                  15      


Ser Ile Lys Cys Cys Leu Glu Glu Gly Leu Glu Pro Thr Cys Phe Glu 
            20                  25                  30          


Arg Ser Asp Asp Leu Gly Gly Leu Trp Arg Phe Thr Glu His Val Glu 
        35                  40                  45              


Glu Gly Arg Ala Ser Leu Tyr Lys Ser Val Val Ser Asn Ser Cys Lys 
    50                  55                  60                  


Glu Met Ser Cys Tyr Ser Asp Phe Pro Phe Pro Glu Asp Tyr Pro Asn 
65                  70                  75                  80  


Tyr Val Pro Asn Ser Gln Phe Leu Glu Tyr Leu Lys Met Tyr Ala Asn 
                85                  90                  95      


His Phe Asp Leu Leu Lys His Ile Gln Phe Lys Ser Gly Ile Gln Leu 
            100                 105                 110         


Thr Glu Gln Gln Leu Phe Pro Ile Ser Cys Ile Arg Asp Ser 
        115                 120                 125     


<210>  5470
<211>  532
<212>  PRT
<213>  Homo Sapiens

<400>  5470

Met Ala Lys Arg Val Ala Ile Val Gly Ala Gly Val Ser Gly Leu Ala 
1               5                   10                  15      


Ser Ile Lys Cys Cys Leu Glu Glu Gly Leu Glu Pro Thr Cys Phe Glu 
            20                  25                  30          


Arg Ser Asp Asp Leu Gly Gly Leu Trp Arg Phe Thr Glu His Val Glu 
        35                  40                  45              


Glu Gly Arg Ala Ser Leu Tyr Lys Ser Val Val Ser Asn Ser Cys Lys 
    50                  55                  60                  


Glu Met Ser Cys Tyr Ser Asp Phe Pro Phe Pro Glu Asp Tyr Pro Asn 
65                  70                  75                  80  


Tyr Val Pro Asn Ser Gln Phe Leu Glu Tyr Leu Lys Met Tyr Ala Asn 
                85                  90                  95      


His Phe Asp Leu Leu Lys His Ile Gln Phe Lys Thr Lys Val Cys Ser 
            100                 105                 110         


Val Thr Lys Cys Ser Asp Ser Ala Val Ser Gly Gln Trp Glu Val Val 
        115                 120                 125             


Thr Met His Glu Glu Lys Gln Glu Ser Ala Ile Phe Asp Ala Val Met 
    130                 135                 140                 


Val Cys Thr Gly Phe Leu Thr Asn Pro Tyr Leu Pro Leu Asp Ser Phe 
145                 150                 155                 160 


Pro Gly Ile Asn Ala Phe Lys Gly Gln Tyr Phe His Ser Arg Gln Tyr 
                165                 170                 175     


Lys His Pro Asp Ile Phe Lys Asp Lys Arg Val Leu Val Ile Gly Met 
            180                 185                 190         


Gly Asn Ser Gly Thr Asp Ile Ala Val Glu Ala Ser His Leu Ala Glu 
        195                 200                 205             


Lys Val Phe Leu Ser Thr Thr Gly Gly Gly Trp Val Ile Ser Arg Ile 
    210                 215                 220                 


Phe Asp Ser Gly Tyr Pro Trp Asp Met Val Phe Met Thr Arg Phe Gln 
225                 230                 235                 240 


Asn Met Leu Arg Asn Ser Leu Pro Thr Pro Ile Val Thr Trp Leu Met 
                245                 250                 255     


Glu Arg Lys Ile Asn Asn Trp Leu Asn His Ala Asn Tyr Gly Leu Ile 
            260                 265                 270         


Pro Glu Asp Arg Thr Gln Leu Lys Glu Phe Val Leu Asn Asp Glu Leu 
        275                 280                 285             


Pro Gly Arg Ile Ile Thr Gly Lys Val Phe Ile Arg Pro Ser Ile Lys 
    290                 295                 300                 


Glu Val Lys Glu Asn Ser Val Ile Phe Asn Asn Thr Ser Lys Glu Glu 
305                 310                 315                 320 


Pro Ile Asp Ile Ile Val Phe Ala Thr Gly Tyr Thr Phe Ala Phe Pro 
                325                 330                 335     


Phe Leu Asp Glu Ser Val Val Lys Val Glu Asp Gly Gln Ala Ser Leu 
            340                 345                 350         


Tyr Lys Tyr Ile Phe Pro Ala His Leu Gln Lys Pro Thr Leu Ala Ile 
        355                 360                 365             


Ile Gly Leu Ile Lys Pro Leu Gly Ser Met Ile Pro Thr Gly Glu Thr 
    370                 375                 380                 


Gln Ala Arg Trp Ala Val Arg Val Leu Lys Gly Val Asn Lys Leu Pro 
385                 390                 395                 400 


Pro Pro Ser Val Met Ile Glu Glu Ile Asn Ala Arg Lys Glu Asn Lys 
                405                 410                 415     


Pro Ser Trp Phe Gly Leu Cys Tyr Cys Lys Ala Leu Gln Ser Asp Tyr 
            420                 425                 430         


Ile Thr Tyr Ile Asp Glu Leu Leu Thr Tyr Ile Asn Ala Lys Pro Asn 
        435                 440                 445             


Leu Phe Ser Met Leu Leu Thr Asp Pro His Leu Ala Leu Thr Val Phe 
    450                 455                 460                 


Phe Gly Pro Cys Ser Pro Tyr Gln Phe Arg Leu Thr Gly Pro Gly Lys 
465                 470                 475                 480 


Trp Glu Gly Ala Arg Asn Ala Ile Met Thr Gln Trp Asp Arg Thr Phe 
                485                 490                 495     


Lys Val Ile Lys Ala Arg Val Val Gln Glu Ser Pro Ser Pro Phe Glu 
            500                 505                 510         


Ser Phe Leu Lys Val Phe Ser Phe Leu Ala Leu Leu Val Ala Ile Phe 
        515                 520                 525             


Leu Ile Phe Leu 
    530         


<210>  5471
<211>  532
<212>  PRT
<213>  Homo Sapiens

<400>  5471

Met Ala Lys Arg Val Ala Ile Val Gly Ala Gly Val Ser Gly Leu Ala 
1               5                   10                  15      


Ser Ile Lys Cys Cys Leu Glu Glu Gly Leu Glu Pro Thr Cys Phe Glu 
            20                  25                  30          


Arg Ser Asp Asp Leu Gly Gly Leu Trp Arg Phe Thr Glu His Val Glu 
        35                  40                  45              


Glu Gly Arg Ala Ser Leu Tyr Lys Ser Val Val Ser Asn Ser Cys Lys 
    50                  55                  60                  


Glu Met Ser Cys Tyr Ser Asp Phe Pro Phe Pro Glu Asp Tyr Pro Asn 
65                  70                  75                  80  


Tyr Val Pro Asn Ser Gln Phe Leu Glu Tyr Leu Lys Met Tyr Ala Asn 
                85                  90                  95      


His Phe Asp Leu Leu Lys His Ile Gln Phe Lys Thr Lys Val Cys Ser 
            100                 105                 110         


Val Thr Lys Cys Ser Asp Ser Ala Val Ser Gly Gln Trp Glu Val Val 
        115                 120                 125             


Thr Met His Glu Glu Lys Gln Glu Ser Ala Ile Phe Asp Ala Val Met 
    130                 135                 140                 


Val Cys Thr Gly Phe Leu Thr Asn Pro Tyr Leu Pro Leu Asp Ser Phe 
145                 150                 155                 160 


Pro Gly Ile Asn Ala Phe Lys Gly Gln Tyr Phe His Ser Arg Gln Tyr 
                165                 170                 175     


Lys His Pro Asp Ile Phe Lys Asp Lys Arg Val Leu Val Ile Gly Met 
            180                 185                 190         


Gly Asn Ser Gly Thr Asp Ile Ala Val Glu Ala Ser His Leu Ala Glu 
        195                 200                 205             


Lys Val Phe Leu Ser Thr Thr Gly Gly Gly Trp Val Ile Ser Arg Ile 
    210                 215                 220                 


Phe Asp Ser Gly Tyr Pro Trp Asp Met Val Phe Met Thr Arg Phe Gln 
225                 230                 235                 240 


Asn Met Leu Arg Asn Ser Leu Pro Thr Pro Ile Val Thr Trp Leu Met 
                245                 250                 255     


Glu Arg Lys Ile Asn Asn Trp Leu Asn His Ala Asn Tyr Gly Leu Ile 
            260                 265                 270         


Pro Glu Asp Arg Thr Gln Leu Lys Glu Phe Val Leu Asn Asp Glu Leu 
        275                 280                 285             


Pro Gly Arg Ile Ile Thr Gly Lys Val Phe Ile Arg Pro Ser Ile Lys 
    290                 295                 300                 


Glu Val Lys Glu Asn Ser Val Ile Phe Asn Asn Thr Ser Lys Glu Glu 
305                 310                 315                 320 


Pro Ile Asp Ile Ile Val Phe Ala Thr Gly Tyr Thr Phe Ala Phe Pro 
                325                 330                 335     


Phe Leu Asp Glu Ser Val Val Lys Val Glu Asp Gly Gln Ala Ser Leu 
            340                 345                 350         


Tyr Lys Tyr Ile Phe Pro Ala His Leu Gln Lys Pro Thr Leu Ala Ile 
        355                 360                 365             


Ile Gly Leu Ile Lys Pro Leu Gly Ser Met Ile Pro Thr Gly Glu Thr 
    370                 375                 380                 


Gln Ala Arg Trp Ala Val Arg Val Leu Lys Gly Val Asn Lys Leu Pro 
385                 390                 395                 400 


Pro Pro Ser Val Met Ile Glu Glu Ile Asn Ala Arg Lys Glu Asn Lys 
                405                 410                 415     


Pro Ser Trp Phe Gly Leu Cys Tyr Cys Lys Ala Leu Gln Ser Asp Tyr 
            420                 425                 430         


Ile Thr Tyr Ile Asp Glu Leu Leu Thr Tyr Ile Asn Ala Lys Pro Asn 
        435                 440                 445             


Leu Phe Ser Met Leu Leu Thr Asp Pro His Leu Ala Leu Thr Val Phe 
    450                 455                 460                 


Phe Gly Pro Cys Ser Pro Tyr Gln Phe Arg Leu Thr Gly Pro Gly Lys 
465                 470                 475                 480 


Trp Glu Gly Ala Arg Asn Ala Ile Met Thr Gln Trp Asp Arg Thr Phe 
                485                 490                 495     


Lys Val Ile Lys Ala Arg Val Val Gln Glu Ser Pro Ser Pro Phe Glu 
            500                 505                 510         


Ser Phe Leu Lys Val Phe Ser Phe Leu Ala Leu Leu Val Ala Ile Phe 
        515                 520                 525             


Leu Ile Phe Leu 
    530         


<210>  5472
<211>  532
<212>  PRT
<213>  Homo Sapiens

<400>  5472

Met Ala Lys Arg Val Ala Ile Val Gly Ala Gly Val Ser Gly Leu Ala 
1               5                   10                  15      


Ser Ile Lys Cys Cys Leu Glu Glu Gly Leu Glu Pro Thr Cys Phe Glu 
            20                  25                  30          


Arg Ser Asp Asp Leu Gly Gly Leu Trp Arg Phe Thr Glu His Val Glu 
        35                  40                  45              


Glu Gly Arg Ala Ser Leu Tyr Lys Ser Val Val Ser Asn Ser Cys Lys 
    50                  55                  60                  


Glu Met Ser Cys Tyr Ser Asp Phe Pro Phe Pro Glu Asp Tyr Pro Asn 
65                  70                  75                  80  


Tyr Val Pro Asn Ser Gln Phe Leu Glu Tyr Leu Lys Met Tyr Ala Asn 
                85                  90                  95      


His Phe Asp Leu Leu Lys His Ile Gln Phe Lys Thr Lys Val Cys Ser 
            100                 105                 110         


Val Thr Lys Cys Ser Asp Ser Ala Val Ser Gly Gln Trp Glu Val Val 
        115                 120                 125             


Thr Met His Glu Glu Lys Gln Glu Ser Ala Ile Phe Asp Ala Val Met 
    130                 135                 140                 


Val Cys Thr Gly Phe Leu Thr Asn Pro Tyr Leu Pro Leu Asp Ser Phe 
145                 150                 155                 160 


Pro Gly Ile Asn Ala Phe Lys Gly Gln Tyr Phe His Ser Arg Gln Tyr 
                165                 170                 175     


Lys His Pro Asp Ile Phe Lys Asp Lys Arg Val Leu Val Ile Gly Met 
            180                 185                 190         


Gly Asn Ser Gly Thr Asp Ile Ala Val Glu Ala Ser His Leu Ala Glu 
        195                 200                 205             


Lys Val Phe Leu Ser Thr Thr Gly Gly Gly Trp Val Ile Ser Arg Ile 
    210                 215                 220                 


Phe Asp Ser Gly Tyr Pro Trp Asp Met Val Phe Met Thr Arg Phe Gln 
225                 230                 235                 240 


Asn Met Leu Arg Asn Ser Leu Pro Thr Pro Ile Val Thr Trp Leu Met 
                245                 250                 255     


Glu Arg Lys Ile Asn Asn Trp Leu Asn His Ala Asn Tyr Gly Leu Ile 
            260                 265                 270         


Pro Glu Asp Arg Thr Gln Leu Lys Glu Phe Val Leu Asn Asp Glu Leu 
        275                 280                 285             


Pro Gly Arg Ile Ile Thr Gly Lys Val Phe Ile Arg Pro Ser Ile Lys 
    290                 295                 300                 


Glu Val Lys Glu Asn Ser Val Ile Phe Asn Asn Thr Ser Lys Glu Glu 
305                 310                 315                 320 


Pro Ile Asp Ile Ile Val Phe Ala Thr Gly Tyr Thr Phe Ala Phe Pro 
                325                 330                 335     


Phe Leu Asp Glu Ser Val Val Lys Val Glu Asp Gly Gln Ala Ser Leu 
            340                 345                 350         


Tyr Lys Tyr Ile Phe Pro Ala His Leu Gln Lys Pro Thr Leu Ala Ile 
        355                 360                 365             


Ile Gly Leu Ile Lys Pro Leu Gly Ser Met Ile Pro Thr Gly Glu Thr 
    370                 375                 380                 


Gln Ala Arg Trp Ala Val Arg Val Leu Lys Gly Val Asn Lys Leu Pro 
385                 390                 395                 400 


Pro Pro Ser Val Met Ile Glu Glu Ile Asn Ala Arg Lys Glu Asn Lys 
                405                 410                 415     


Pro Ser Trp Phe Gly Leu Cys Tyr Cys Lys Ala Leu Gln Ser Asp Tyr 
            420                 425                 430         


Ile Thr Tyr Ile Asp Glu Leu Leu Thr Tyr Ile Asn Ala Lys Pro Asn 
        435                 440                 445             


Leu Phe Ser Met Leu Leu Thr Asp Pro His Leu Ala Leu Thr Val Phe 
    450                 455                 460                 


Phe Gly Pro Cys Ser Pro Tyr Gln Phe Arg Leu Thr Gly Pro Gly Lys 
465                 470                 475                 480 


Trp Glu Gly Ala Arg Asn Ala Ile Met Thr Gln Trp Asp Arg Thr Phe 
                485                 490                 495     


Lys Val Ile Lys Ala Arg Val Val Gln Glu Ser Pro Ser Pro Phe Glu 
            500                 505                 510         


Ser Phe Leu Lys Val Phe Ser Phe Leu Ala Leu Leu Val Ala Ile Phe 
        515                 520                 525             


Leu Ile Phe Leu 
    530         


<210>  5473
<211>  469
<212>  PRT
<213>  Homo Sapiens

<400>  5473

Met Ala Lys Arg Val Ala Ile Val Gly Ala Gly Val Ser Gly Leu Ala 
1               5                   10                  15      


Ser Ile Lys Cys Cys Leu Glu Glu Gly Leu Glu Pro Thr Cys Phe Glu 
            20                  25                  30          


Arg Ser Asp Asp Leu Gly Gly Leu Trp Arg Phe Thr Thr Lys Val Cys 
        35                  40                  45              


Ser Val Thr Lys Cys Ser Asp Ser Ala Val Ser Gly Gln Trp Glu Val 
    50                  55                  60                  


Val Thr Met His Glu Glu Lys Gln Glu Ser Ala Ile Phe Asp Ala Val 
65                  70                  75                  80  


Met Val Cys Thr Gly Phe Leu Thr Asn Pro Tyr Leu Pro Leu Asp Ser 
                85                  90                  95      


Phe Pro Gly Ile Asn Ala Phe Lys Gly Gln Tyr Phe His Ser Arg Gln 
            100                 105                 110         


Tyr Lys His Pro Asp Ile Phe Lys Asp Lys Arg Val Leu Val Ile Gly 
        115                 120                 125             


Met Gly Asn Ser Gly Thr Asp Ile Ala Val Glu Ala Ser His Leu Ala 
    130                 135                 140                 


Glu Lys Val Phe Leu Ser Thr Thr Gly Gly Gly Trp Val Ile Ser Arg 
145                 150                 155                 160 


Ile Phe Asp Ser Gly Tyr Pro Trp Asp Met Val Phe Met Thr Arg Phe 
                165                 170                 175     


Gln Asn Met Leu Arg Asn Ser Leu Pro Thr Pro Ile Val Thr Trp Leu 
            180                 185                 190         


Met Glu Arg Lys Ile Asn Asn Trp Leu Asn His Ala Asn Tyr Gly Leu 
        195                 200                 205             


Ile Pro Glu Asp Arg Thr Gln Leu Lys Glu Phe Val Leu Asn Asp Glu 
    210                 215                 220                 


Leu Pro Gly Arg Ile Ile Thr Gly Lys Val Phe Ile Arg Pro Ser Ile 
225                 230                 235                 240 


Lys Glu Val Lys Glu Asn Ser Val Ile Phe Asn Asn Thr Ser Lys Glu 
                245                 250                 255     


Glu Pro Ile Asp Ile Ile Val Phe Ala Thr Gly Tyr Thr Phe Ala Phe 
            260                 265                 270         


Pro Phe Leu Asp Glu Ser Val Val Lys Val Glu Asp Gly Gln Ala Ser 
        275                 280                 285             


Leu Tyr Lys Tyr Ile Phe Pro Ala His Leu Gln Lys Pro Thr Leu Ala 
    290                 295                 300                 


Ile Ile Gly Leu Ile Lys Pro Leu Gly Ser Met Ile Pro Thr Gly Glu 
305                 310                 315                 320 


Thr Gln Ala Arg Trp Ala Val Arg Val Leu Lys Gly Val Asn Lys Leu 
                325                 330                 335     


Pro Pro Pro Ser Val Met Ile Glu Glu Ile Asn Ala Arg Lys Glu Asn 
            340                 345                 350         


Lys Pro Ser Trp Phe Gly Leu Cys Tyr Cys Lys Ala Leu Gln Ser Asp 
        355                 360                 365             


Tyr Ile Thr Tyr Ile Asp Glu Leu Leu Thr Tyr Ile Asn Ala Lys Pro 
    370                 375                 380                 


Asn Leu Phe Ser Met Leu Leu Thr Asp Pro His Leu Ala Leu Thr Val 
385                 390                 395                 400 


Phe Phe Gly Pro Cys Ser Pro Tyr Gln Phe Arg Leu Thr Gly Pro Gly 
                405                 410                 415     


Lys Trp Glu Gly Ala Arg Asn Ala Ile Met Thr Gln Trp Asp Arg Thr 
            420                 425                 430         


Phe Lys Val Ile Lys Ala Arg Val Val Gln Glu Ser Pro Ser Pro Phe 
        435                 440                 445             


Glu Ser Phe Leu Lys Val Phe Ser Phe Leu Ala Leu Leu Val Ala Ile 
    450                 455                 460                 


Phe Leu Ile Phe Leu 
465                 


<210>  5474
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  5474

Met Ala Lys Lys Val Ala Val Ile Gly Ala Gly Val Ser Gly Leu Ile 
1               5                   10                  15      


Ser Leu Lys Cys Cys Val Asp Glu Gly Leu Glu Pro Thr Cys Phe Glu 
            20                  25                  30          


Arg Thr Glu Asp Ile Gly Gly Val Trp Arg Phe Lys Glu Asn Val Glu 
        35                  40                  45              


Asp Gly Arg Ala Ser Ile Tyr Gln Ser Val Val Thr Asn Thr Ser Lys 
    50                  55                  60                  


Glu Met Ser Cys Phe Ser Asp Phe Pro Met Pro Glu Asp Phe Pro Asn 
65                  70                  75                  80  


Phe Leu His Asn Ser Lys Leu Leu Glu Tyr Phe Arg Ile Phe Ala Lys 
                85                  90                  95      


Lys Phe Asp Leu Leu Lys Tyr Ile Gln Phe Gln Thr Thr Val Leu Ser 
            100                 105                 110         


Val Arg Lys Cys Pro Asp Phe Ser Ser Ser Gly Gln Trp Lys Val Val 
        115                 120                 125             


Thr Gln Ser 
    130     


<210>  5475
<211>  535
<212>  PRT
<213>  Homo Sapiens

<400>  5475

Met Ala Lys Lys Val Ala Val Ile Gly Ala Gly Val Ser Gly Leu Ile 
1               5                   10                  15      


Ser Leu Lys Cys Cys Val Asp Glu Gly Leu Glu Pro Thr Cys Phe Glu 
            20                  25                  30          


Arg Thr Glu Asp Ile Gly Gly Val Trp Arg Phe Lys Glu Asn Val Glu 
        35                  40                  45              


Asp Gly Arg Ala Ser Ile Tyr Gln Ser Val Val Thr Asn Thr Ser Lys 
    50                  55                  60                  


Glu Met Ser Cys Phe Ser Asp Phe Pro Met Pro Glu Asp Phe Pro Asn 
65                  70                  75                  80  


Phe Leu His Asn Ser Lys Leu Leu Glu Tyr Phe Arg Ile Phe Ala Lys 
                85                  90                  95      


Lys Phe Asp Leu Leu Lys Tyr Ile Gln Phe Gln Thr Thr Val Leu Ser 
            100                 105                 110         


Val Arg Lys Cys Pro Asp Phe Ser Ser Ser Gly Gln Trp Lys Val Val 
        115                 120                 125             


Thr Gln Ser Asn Gly Lys Glu Gln Ser Ala Val Phe Asp Ala Val Met 
    130                 135                 140                 


Val Cys Ser Gly His His Ile Leu Pro His Ile Pro Leu Lys Ser Phe 
145                 150                 155                 160 


Pro Gly Met Glu Arg Phe Lys Gly Gln Tyr Phe His Ser Arg Gln Tyr 
                165                 170                 175     


Lys His Pro Asp Gly Phe Glu Gly Lys Arg Ile Leu Val Ile Gly Met 
            180                 185                 190         


Gly Asn Ser Gly Ser Asp Ile Ala Val Glu Leu Ser Lys Asn Ala Ala 
        195                 200                 205             


Gln Val Phe Ile Ser Thr Arg His Gly Thr Trp Val Met Ser Arg Ile 
    210                 215                 220                 


Ser Glu Asp Gly Tyr Pro Trp Asp Ser Val Phe His Thr Arg Phe Arg 
225                 230                 235                 240 


Ser Met Leu Arg Asn Val Leu Pro Arg Thr Ala Val Lys Trp Met Ile 
                245                 250                 255     


Glu Gln Gln Met Asn Arg Trp Phe Asn His Glu Asn Tyr Gly Leu Glu 
            260                 265                 270         


Pro Gln Asn Lys Tyr Ile Met Lys Glu Pro Val Leu Asn Asp Asp Val 
        275                 280                 285             


Pro Ser Arg Leu Leu Cys Gly Ala Ile Lys Val Lys Ser Thr Val Lys 
    290                 295                 300                 


Glu Leu Thr Glu Thr Ser Ala Ile Phe Glu Asp Gly Thr Val Glu Glu 
305                 310                 315                 320 


Asn Ile Asp Val Ile Ile Phe Ala Thr Gly Tyr Ser Phe Ser Phe Pro 
                325                 330                 335     


Phe Leu Glu Asp Ser Leu Val Lys Val Glu Asn Asn Met Val Ser Leu 
            340                 345                 350         


Tyr Lys Tyr Ile Phe Pro Ala His Leu Asp Lys Ser Thr Leu Ala Cys 
        355                 360                 365             


Ile Gly Leu Ile Gln Pro Leu Gly Ser Ile Phe Pro Thr Ala Glu Leu 
    370                 375                 380                 


Gln Ala Arg Trp Val Thr Arg Val Phe Lys Gly Leu Cys Ser Leu Pro 
385                 390                 395                 400 


Ser Glu Arg Thr Met Met Met Asp Ile Ile Lys Arg Asn Glu Lys Arg 
                405                 410                 415     


Ile Asp Leu Phe Gly Glu Ser Gln Ser Gln Thr Leu Gln Thr Asn Tyr 
            420                 425                 430         


Val Asp Tyr Leu Asp Glu Leu Ala Leu Glu Ile Gly Ala Lys Pro Asp 
        435                 440                 445             


Phe Cys Ser Leu Leu Phe Lys Asp Pro Lys Leu Ala Val Arg Leu Tyr 
    450                 455                 460                 


Phe Gly Pro Cys Asn Ser Tyr Gln Tyr Arg Leu Val Gly Pro Gly Gln 
465                 470                 475                 480 


Trp Glu Gly Ala Arg Asn Ala Ile Phe Thr Gln Lys Gln Arg Ile Leu 
                485                 490                 495     


Lys Pro Leu Lys Thr Arg Ala Leu Lys Asp Ser Ser Asn Phe Ser Val 
            500                 505                 510         


Ser Phe Leu Leu Lys Ile Leu Gly Leu Leu Ala Val Val Val Ala Phe 
        515                 520                 525             


Phe Cys Gln Leu Gln Trp Ser 
    530                 535 


<210>  5476
<211>  153
<212>  PRT
<213>  Homo Sapiens

<400>  5476

Thr Gln Pro Arg Glu Lys Thr Ile Leu Ser Lys Arg Arg Cys Gln Lys 
1               5                   10                  15      


Ala Lys Thr Lys Glu Asn Val Glu Asp Gly Arg Ala Ser Ile Tyr Gln 
            20                  25                  30          


Ser Val Val Thr Asn Thr Ser Lys Glu Met Ser Cys Phe Ser Asp Phe 
        35                  40                  45              


Pro Met Pro Glu Asp Phe Pro Asn Phe Leu His Asn Ser Lys Leu Leu 
    50                  55                  60                  


Glu Tyr Phe Arg Ile Phe Ala Lys Lys Phe Asp Leu Leu Lys Tyr Ile 
65                  70                  75                  80  


Gln Phe Gln Thr Thr Val Leu Ser Val Arg Lys Cys Pro Asp Phe Ser 
                85                  90                  95      


Ser Ser Gly Gln Trp Lys Val Val Thr Gln Ser Asn Gly Lys Glu Gln 
            100                 105                 110         


Ser Ala Val Phe Asp Ala Val Met Val Cys Ser Gly His His Ile Leu 
        115                 120                 125             


Pro His Ile Pro Leu Lys Ser Phe Pro Gly Phe Tyr Gln His Gln Ala 
    130                 135                 140                 


Trp His Leu Gly His Glu Pro Tyr Leu 
145                 150             


<210>  5477
<211>  218
<212>  PRT
<213>  Homo Sapiens

<400>  5477

Met Gly Lys Lys Val Ala Ile Ile Gly Ala Gly Val Ser Gly Leu Ala 
1               5                   10                  15      


Ser Ile Arg Ser Cys Leu Glu Glu Gly Leu Glu Pro Thr Cys Phe Glu 
            20                  25                  30          


Lys Ser Asn Asp Ile Gly Gly Leu Trp Lys Phe Ser Asp His Ala Glu 
        35                  40                  45              


Glu Gly Arg Ala Ser Ile Tyr Lys Ser Val Phe Ser Asn Ser Ser Lys 
    50                  55                  60                  


Glu Met Met Cys Phe Pro Asp Phe Pro Phe Pro Asp Asp Phe Pro Asn 
65                  70                  75                  80  


Phe Met His Asn Ser Lys Ile Gln Glu Tyr Ile Ile Ala Phe Ala Lys 
                85                  90                  95      


Glu Lys Asn Leu Leu Lys Tyr Ile Gln Phe Lys Thr Phe Val Ser Ser 
            100                 105                 110         


Val Asn Lys His Pro Asp Phe Ala Thr Thr Gly Gln Trp Asp Val Thr 
        115                 120                 125             


Thr Glu Arg Asp Gly Lys Lys Glu Ser Ala Val Phe Asp Ala Val Met 
    130                 135                 140                 


Val Cys Ser Gly His His Val Tyr Pro Asn Leu Pro Asp Tyr Lys Glu 
145                 150                 155                 160 


Pro Gly Val Phe Asn Gly Lys Arg Val Leu Val Val Gly Leu Gly Asn 
                165                 170                 175     


Ser Gly Cys Asp Ile Ala Thr Glu Leu Ser Arg Thr Ala Glu Gln Val 
            180                 185                 190         


Met Ile Ser Ser Arg Ser Gly Ser Trp Val Met Ser Arg Val Trp Asp 
        195                 200                 205             


Asn Gly Tyr Pro Trp Asp Met Leu Leu Val 
    210                 215             


<210>  5478
<211>  532
<212>  PRT
<213>  Homo Sapiens

<400>  5478

Met Gly Lys Lys Val Ala Ile Ile Gly Ala Gly Val Ser Gly Leu Ala 
1               5                   10                  15      


Ser Ile Arg Ser Cys Leu Glu Glu Gly Leu Glu Pro Thr Cys Phe Glu 
            20                  25                  30          


Lys Ser Asn Asp Ile Gly Gly Leu Trp Lys Phe Ser Asp His Ala Glu 
        35                  40                  45              


Glu Gly Arg Ala Ser Ile Tyr Lys Ser Val Phe Ser Asn Ser Ser Lys 
    50                  55                  60                  


Glu Met Met Cys Phe Pro Asp Phe Pro Phe Pro Asp Asp Phe Pro Asn 
65                  70                  75                  80  


Phe Met His Asn Ser Lys Ile Gln Glu Tyr Ile Ile Ala Phe Ala Lys 
                85                  90                  95      


Glu Lys Asn Leu Leu Lys Tyr Ile Gln Phe Lys Thr Phe Val Ser Ser 
            100                 105                 110         


Val Asn Lys His Pro Asp Phe Ala Thr Thr Gly Gln Trp Asp Val Thr 
        115                 120                 125             


Thr Glu Arg Asp Gly Lys Lys Glu Ser Ala Val Phe Asp Ala Val Met 
    130                 135                 140                 


Val Cys Ser Gly His His Val Tyr Pro Asn Leu Pro Lys Glu Ser Phe 
145                 150                 155                 160 


Pro Gly Leu Asn His Phe Lys Gly Lys Cys Phe His Ser Arg Asp Tyr 
                165                 170                 175     


Lys Glu Pro Gly Val Phe Asn Gly Lys Arg Val Leu Val Val Gly Leu 
            180                 185                 190         


Gly Asn Ser Gly Cys Asp Ile Ala Thr Glu Leu Ser Arg Thr Ala Glu 
        195                 200                 205             


Gln Val Met Ile Ser Ser Arg Ser Gly Ser Trp Val Met Ser Arg Val 
    210                 215                 220                 


Trp Asp Asn Gly Tyr Pro Trp Asp Met Leu Leu Val Thr Arg Phe Gly 
225                 230                 235                 240 


Thr Phe Leu Lys Asn Asn Leu Pro Thr Ala Ile Ser Asp Trp Leu Tyr 
                245                 250                 255     


Val Lys Gln Met Asn Ala Arg Phe Lys His Glu Asn Tyr Gly Leu Met 
            260                 265                 270         


Pro Leu Asn Gly Val Leu Arg Lys Glu Pro Val Phe Asn Asp Glu Leu 
        275                 280                 285             


Pro Ala Ser Ile Leu Cys Gly Ile Val Ser Val Lys Pro Asn Val Lys 
    290                 295                 300                 


Glu Phe Thr Glu Thr Ser Ala Ile Phe Glu Asp Gly Thr Ile Phe Glu 
305                 310                 315                 320 


Gly Ile Asp Cys Val Ile Phe Ala Thr Gly Tyr Ser Phe Ala Tyr Pro 
                325                 330                 335     


Phe Leu Asp Glu Ser Ile Ile Lys Ser Arg Asn Asn Glu Ile Ile Leu 
            340                 345                 350         


Phe Lys Gly Val Phe Pro Pro Leu Leu Glu Lys Ser Thr Ile Ala Val 
        355                 360                 365             


Ile Gly Phe Val Gln Ser Leu Gly Ala Ala Ile Pro Thr Val Asp Leu 
    370                 375                 380                 


Gln Ser Arg Trp Ala Ala Gln Val Ile Lys Gly Thr Cys Thr Leu Pro 
385                 390                 395                 400 


Ser Met Glu Asp Met Met Asn Asp Ile Asn Glu Lys Met Glu Lys Lys 
                405                 410                 415     


Arg Lys Trp Phe Gly Lys Ser Glu Thr Ile Gln Thr Asp Tyr Ile Val 
            420                 425                 430         


Tyr Met Asp Glu Leu Ser Ser Phe Ile Gly Ala Lys Pro Asn Ile Pro 
        435                 440                 445             


Trp Leu Phe Leu Thr Asp Pro Lys Leu Ala Met Glu Val Tyr Phe Gly 
    450                 455                 460                 


Pro Cys Ser Pro Tyr Gln Phe Arg Leu Val Gly Pro Gly Gln Trp Pro 
465                 470                 475                 480 


Gly Ala Arg Asn Ala Ile Leu Thr Gln Trp Asp Arg Ser Leu Lys Pro 
                485                 490                 495     


Met Gln Thr Arg Val Val Gly Arg Leu Gln Lys Pro Cys Phe Phe Phe 
            500                 505                 510         


His Trp Leu Lys Leu Phe Ala Ile Pro Ile Leu Leu Ile Ala Val Phe 
        515                 520                 525             


Leu Val Leu Thr 
    530         


<210>  5479
<211>  48
<212>  PRT
<213>  Homo Sapiens

<400>  5479

Met Gly Lys Lys Val Ala Ile Ile Gly Ala Gly Val Ser Gly Leu Ala 
1               5                   10                  15      


Ser Ile Arg Ser Cys Leu Glu Glu Gly Leu Glu Pro Thr Cys Phe Glu 
            20                  25                  30          


Lys Ser Asn Asp Ile Gly Gly Leu Trp Lys Phe Ser Arg Ser His Glu 
        35                  40                  45              


<210>  5480
<211>  145
<212>  PRT
<213>  Homo Sapiens

<400>  5480

Met Thr Lys Lys Arg Ile Ala Val Ile Gly Gly Gly Val Ser Gly Leu 
1               5                   10                  15      


Ser Ser Ile Lys Cys Cys Val Glu Glu Gly Leu Glu Pro Val Cys Phe 
            20                  25                  30          


Glu Arg Thr Asp Asp Ile Gly Gly Leu Trp Arg Phe Gln Glu Asn Pro 
        35                  40                  45              


Glu Glu Gly Arg Ala Ser Ile Tyr Lys Ser Val Ile Ile Asn Thr Ser 
    50                  55                  60                  


Lys Glu Met Met Cys Phe Ser Asp Tyr Pro Ile Pro Asp His Tyr Pro 
65                  70                  75                  80  


Asn Phe Met His Asn Ala Gln Val Leu Glu Tyr Phe Arg Met Tyr Ala 
                85                  90                  95      


Lys Glu Phe Asp Leu Leu Lys Tyr Ile Arg Phe Lys Thr Thr Val Cys 
            100                 105                 110         


Ser Val Lys Lys Gln Pro Asp Phe Ala Thr Ser Gly Gln Trp Glu Val 
        115                 120                 125             


Val Thr Glu Ser Glu Gly Lys Lys Glu Met Asn Val Phe Asp Gly Val 
    130                 135                 140                 


Met 
145 


<210>  5481
<211>  192
<212>  PRT
<213>  Homo Sapiens

<400>  5481

Met Thr Lys Lys Arg Ile Ala Val Ile Gly Gly Gly Val Ser Gly Leu 
1               5                   10                  15      


Ser Ser Ile Lys Cys Cys Val Glu Glu Gly Leu Glu Pro Val Cys Phe 
            20                  25                  30          


Glu Arg Thr Asp Asp Ile Gly Gly Leu Trp Arg Phe Gln Glu Asn Pro 
        35                  40                  45              


Glu Glu Gly Arg Ala Ser Ile Tyr Lys Ser Val Ile Ile Asn Thr Ser 
    50                  55                  60                  


Lys Glu Met Met Cys Phe Ser Asp Tyr Pro Ile Pro Asp His Tyr Pro 
65                  70                  75                  80  


Asn Phe Met His Asn Ala Gln Val Leu Glu Tyr Phe Arg Met Tyr Ala 
                85                  90                  95      


Lys Glu Phe Asp Leu Leu Lys Tyr Ile Arg Phe Lys Thr Thr Val Cys 
            100                 105                 110         


Ser Val Lys Lys Gln Pro Asp Phe Ala Thr Ser Gly Gln Trp Glu Val 
        115                 120                 125             


Val Thr Glu Ser Glu Gly Lys Lys Glu Met Asn Val Phe Asp Gly Val 
    130                 135                 140                 


Met Val Cys Thr Gly His His Thr Asn Ala His Leu Pro Leu Glu Ser 
145                 150                 155                 160 


Phe Pro Gly Ile Glu Lys Phe Lys Gly Gln Tyr Phe His Ser Arg Asp 
                165                 170                 175     


Tyr Lys Asn Pro Glu Gly Phe Thr Gly Lys Arg Val Ile Ile Ile Gly 
            180                 185                 190         


<210>  5482
<211>  533
<212>  PRT
<213>  Homo Sapiens

<400>  5482

Met Thr Lys Lys Arg Ile Ala Val Ile Gly Gly Gly Val Ser Gly Leu 
1               5                   10                  15      


Ser Ser Ile Lys Cys Cys Val Glu Glu Gly Leu Glu Pro Val Cys Phe 
            20                  25                  30          


Glu Arg Thr Asp Asp Ile Gly Gly Leu Trp Arg Phe Gln Glu Asn Pro 
        35                  40                  45              


Glu Glu Gly Arg Ala Ser Ile Tyr Lys Ser Val Ile Ile Asn Thr Ser 
    50                  55                  60                  


Lys Glu Met Met Cys Phe Ser Asp Tyr Pro Ile Pro Asp His Tyr Pro 
65                  70                  75                  80  


Asn Phe Met His Asn Ala Gln Val Leu Glu Tyr Phe Arg Met Tyr Ala 
                85                  90                  95      


Lys Glu Phe Asp Leu Leu Lys Tyr Ile Arg Phe Lys Thr Thr Val Cys 
            100                 105                 110         


Ser Val Lys Lys Gln Pro Asp Phe Ala Thr Ser Gly Gln Trp Glu Val 
        115                 120                 125             


Val Thr Glu Ser Glu Gly Lys Lys Glu Met Asn Val Phe Asp Gly Val 
    130                 135                 140                 


Met Val Cys Thr Gly His His Thr Asn Ala His Leu Pro Leu Glu Ser 
145                 150                 155                 160 


Phe Pro Gly Ile Glu Lys Phe Lys Gly Gln Tyr Phe His Ser Arg Asp 
                165                 170                 175     


Tyr Lys Asn Pro Glu Gly Phe Thr Gly Lys Arg Val Ile Ile Ile Gly 
            180                 185                 190         


Ile Gly Asn Ser Gly Gly Asp Leu Ala Val Glu Ile Ser Gln Thr Ala 
        195                 200                 205             


Lys Gln Val Phe Leu Ser Thr Arg Arg Gly Ala Trp Ile Leu Asn Arg 
    210                 215                 220                 


Val Gly Asp Tyr Gly Tyr Pro Ala Asp Val Leu Phe Ser Ser Arg Leu 
225                 230                 235                 240 


Thr His Phe Ile Trp Lys Ile Cys Gly Gln Ser Leu Ala Asn Lys Tyr 
                245                 250                 255     


Leu Glu Lys Lys Ile Asn Gln Arg Phe Asp His Glu Met Phe Gly Leu 
            260                 265                 270         


Lys Pro Lys His Arg Ala Leu Ser Gln His Pro Thr Leu Asn Asp Asp 
        275                 280                 285             


Leu Pro Asn Arg Ile Ile Ser Gly Leu Val Lys Val Lys Gly Asn Val 
    290                 295                 300                 


Lys Glu Phe Thr Glu Thr Ala Ala Ile Phe Glu Asp Gly Ser Arg Glu 
305                 310                 315                 320 


Asp Asp Ile Asp Ala Val Ile Phe Ala Thr Gly Tyr Ser Phe Asp Phe 
                325                 330                 335     


Pro Phe Leu Glu Asp Ser Val Lys Val Val Lys Asn Lys Ile Ser Leu 
            340                 345                 350         


Tyr Lys Lys Val Phe Pro Pro Asn Leu Glu Arg Pro Thr Leu Ala Ile 
        355                 360                 365             


Ile Gly Leu Ile Gln Pro Leu Gly Ala Ile Met Pro Ile Ser Glu Leu 
    370                 375                 380                 


Gln Gly Arg Trp Ala Thr Gln Val Phe Lys Gly Leu Lys Thr Leu Pro 
385                 390                 395                 400 


Ser Gln Ser Glu Met Met Ala Glu Ile Ser Lys Ala Gln Glu Glu Ile 
                405                 410                 415     


Asp Lys Arg Tyr Val Glu Ser Gln Arg His Thr Ile Gln Gly Asp Tyr 
            420                 425                 430         


Ile Asp Thr Met Glu Glu Leu Ala Asp Leu Val Gly Val Arg Pro Asn 
        435                 440                 445             


Leu Leu Ser Leu Ala Phe Thr Asp Pro Lys Leu Ala Leu His Leu Leu 
    450                 455                 460                 


Leu Gly Pro Cys Thr Pro Ile His Tyr Arg Val Gln Gly Pro Gly Lys 
465                 470                 475                 480 


Trp Asp Gly Ala Arg Lys Ala Ile Leu Thr Thr Asp Asp Arg Ile Arg 
                485                 490                 495     


Lys Pro Leu Met Thr Arg Val Val Glu Arg Ser Ser Ser Met Thr Ser 
            500                 505                 510         


Thr Met Thr Ile Gly Lys Phe Met Leu Ala Leu Ala Phe Phe Ala Ile 
        515                 520                 525             


Ile Ile Ala Tyr Phe 
    530             


<210>  5483
<211>  285
<212>  PRT
<213>  Homo Sapiens

<400>  5483

Met Thr Lys Lys Arg Ile Ala Val Ile Gly Gly Gly Val Ser Gly Leu 
1               5                   10                  15      


Ser Ser Ile Lys Cys Cys Val Glu Glu Gly Leu Glu Pro Val Cys Phe 
            20                  25                  30          


Glu Arg Thr Asp Asp Ile Gly Gly Leu Trp Arg Phe Gln Glu Asn Pro 
        35                  40                  45              


Glu Glu Gly Arg Ala Ser Ile Tyr Lys Ser Val Ile Ile Asn Thr Ser 
    50                  55                  60                  


Lys Glu Met Met Cys Phe Ser Asp Tyr Pro Ile Pro Asp His Tyr Pro 
65                  70                  75                  80  


Asn Phe Met His Asn Ala Gln Val Leu Glu Tyr Phe Arg Met Tyr Ala 
                85                  90                  95      


Lys Glu Phe Asp Leu Leu Lys Tyr Ile Arg Phe Lys Thr Thr Val Cys 
            100                 105                 110         


Ser Val Lys Lys Gln Pro Asp Phe Ala Thr Ser Gly Gln Trp Glu Val 
        115                 120                 125             


Val Thr Glu Ser Glu Gly Lys Lys Glu Met Asn Val Phe Asp Gly Val 
    130                 135                 140                 


Met Val Cys Thr Gly His His Thr Asn Ala His Leu Pro Leu Glu Ser 
145                 150                 155                 160 


Phe Pro Gly Ile Glu Lys Phe Lys Gly Gln Tyr Phe His Ser Arg Asp 
                165                 170                 175     


Tyr Lys Asn Pro Glu Gly Phe Thr Gly Lys Arg Val Ile Ile Ile Gly 
            180                 185                 190         


Ile Gly Asn Ser Gly Gly Asp Leu Ala Val Glu Ile Ser Gln Thr Ala 
        195                 200                 205             


Lys Gln Val Phe Leu Ser Thr Arg Arg Gly Ala Trp Ile Leu Asn Arg 
    210                 215                 220                 


Val Gly Asp Tyr Gly Tyr Pro Ala Asp Val Leu Phe Ser Ser Arg Leu 
225                 230                 235                 240 


Thr His Phe Ile Trp Lys Ile Cys Gly Gln Ser Leu Ala Asn Lys Tyr 
                245                 250                 255     


Leu Glu Lys Lys Ile Asn Gln Arg Phe Asp His Glu Met Phe Gly Leu 
            260                 265                 270         


Lys Pro Lys His Arg Ser Lys Asp Ile Ala Leu Thr Glu 
        275                 280                 285 


<210>  5484
<211>  464
<212>  PRT
<213>  Homo Sapiens

<400>  5484

Met Thr Lys Lys Arg Ile Ala Val Ile Gly Gly Gly Val Ser Gly Leu 
1               5                   10                  15      


Ser Ser Ile Lys Cys Cys Val Glu Glu Gly Leu Glu Pro Val Cys Phe 
            20                  25                  30          


Glu Arg Thr Asp Asp Ile Gly Gly Leu Trp Arg Phe Gln Glu Asn Pro 
        35                  40                  45              


Glu Glu Gly Arg Ala Ser Ile Tyr Lys Ser Val Ile Ile Asn Thr Ser 
    50                  55                  60                  


Lys Glu Met Met Cys Phe Ser Asp Tyr Pro Ile Pro Asp His Tyr Pro 
65                  70                  75                  80  


Asn Phe Met His Asn Ala Gln Val Leu Glu Tyr Phe Arg Met Tyr Ala 
                85                  90                  95      


Lys Glu Phe Asp Leu Leu Lys Tyr Ile Arg Phe Lys Thr Thr Val Cys 
            100                 105                 110         


Ser Val Lys Lys Gln Pro Asp Phe Ala Thr Ser Gly Gln Trp Glu Val 
        115                 120                 125             


Val Thr Glu Ser Glu Gly Lys Lys Glu Met Asn Val Phe Asp Gly Val 
    130                 135                 140                 


Met Val Cys Thr Gly His His Thr Asn Ala His Leu Pro Leu Glu Ser 
145                 150                 155                 160 


Phe Pro Gly Ile Glu Lys Phe Lys Gly Gln Tyr Phe His Ser Arg Asp 
                165                 170                 175     


Tyr Lys Asn Pro Glu Gly Phe Thr Gly Lys Arg Val Ile Ile Ile Gly 
            180                 185                 190         


Ile Gly Asn Ser Gly Gly Asp Leu Ala Val Glu Ile Ser Gln Thr Ala 
        195                 200                 205             


Lys Gln Val Phe Leu Ser Thr Arg Arg Gly Ala Trp Ile Leu Asn Arg 
    210                 215                 220                 


Val Gly Asp Tyr Gly Tyr Pro Ala Asp Val Leu Phe Ser Ser Arg Leu 
225                 230                 235                 240 


Thr His Phe Ile Trp Lys Ile Cys Gly Gln Ser Leu Ala Asn Lys Tyr 
                245                 250                 255     


Leu Glu Lys Lys Ile Asn Gln Arg Phe Asp His Glu Met Phe Gly Leu 
            260                 265                 270         


Lys Pro Lys His Arg Ala Leu Ser Gln His Pro Thr Leu Asn Asp Asp 
        275                 280                 285             


Leu Pro Asn Arg Ile Ile Ser Gly Leu Val Lys Val Lys Gly Asn Val 
    290                 295                 300                 


Lys Glu Phe Thr Glu Thr Ala Ala Ile Phe Glu Asp Gly Ser Arg Glu 
305                 310                 315                 320 


Asp Asp Ile Asp Ala Val Ile Phe Ala Thr Gly Tyr Ser Phe Asp Phe 
                325                 330                 335     


Pro Phe Leu Glu Asp Ser Val Lys Val Val Lys Asn Lys Ile Ser Leu 
            340                 345                 350         


Tyr Lys Lys Val Phe Pro Pro Asn Leu Glu Arg Pro Thr Leu Ala Ile 
        355                 360                 365             


Ile Gly Leu Ile Gln Pro Leu Gly Ala Ile Met Pro Ile Ser Glu Leu 
    370                 375                 380                 


Gln Gly Arg Trp Ala Thr Gln Val Phe Lys Gly Leu Lys Thr Leu Pro 
385                 390                 395                 400 


Ser Gln Ser Glu Met Met Ala Glu Ile Ser Lys Ala Gln Glu Glu Ile 
                405                 410                 415     


Asp Lys Ser Leu Thr Met Arg Lys Thr Ser Asp Lys Pro Lys Leu Lys 
            420                 425                 430         


Asn Ile Leu Gln Ile Pro Asp Tyr Leu Lys Thr Val Lys Ile Ile Asn 
        435                 440                 445             


Lys Glu Ser Leu Arg Asn Cys Pro Gly Ile Lys Gly Pro Lys Glu Thr 
    450                 455                 460                 


<210>  5485
<211>  278
<212>  PRT
<213>  Homo Sapiens

<400>  5485

Met Thr Lys Lys Arg Ile Ala Val Ile Gly Gly Gly Val Ser Gly Leu 
1               5                   10                  15      


Ser Ser Ile Lys Cys Cys Val Glu Glu Gly Leu Glu Pro Val Cys Phe 
            20                  25                  30          


Glu Arg Thr Asp Asp Ile Gly Gly Leu Trp Arg Phe Gln Glu Asn Pro 
        35                  40                  45              


Glu Glu Gly Arg Ala Ser Ile Tyr Lys Ser Val Ile Ile Asn Thr Ser 
    50                  55                  60                  


Lys Glu Met Met Cys Phe Ser Asp Tyr Pro Ile Pro Asp His Tyr Pro 
65                  70                  75                  80  


Asn Phe Met His Asn Ala Gln Val Leu Glu Tyr Phe Arg Met Tyr Ala 
                85                  90                  95      


Lys Glu Phe Asp Leu Leu Lys Tyr Ile Arg Phe Lys Thr Thr Val Cys 
            100                 105                 110         


Ser Val Lys Lys Gln Pro Asp Phe Ala Thr Ser Gly Gln Trp Glu Val 
        115                 120                 125             


Val Thr Glu Ser Glu Gly Lys Lys Glu Met Asn Val Phe Asp Gly Val 
    130                 135                 140                 


Met Val Cys Thr Gly His His Thr Asn Ala His Leu Pro Leu Glu Ser 
145                 150                 155                 160 


Phe Pro Gly Ile Glu Lys Phe Lys Gly Gln Tyr Phe His Ser Arg Asp 
                165                 170                 175     


Tyr Lys Asn Pro Glu Gly Phe Thr Gly Lys Arg Val Ile Ile Ile Gly 
            180                 185                 190         


Ile Gly Asn Ser Gly Gly Asp Leu Ala Val Glu Ile Ser Gln Thr Ala 
        195                 200                 205             


Lys Gln Val Phe Leu Ser Thr Arg Arg Gly Ala Trp Ile Leu Asn Arg 
    210                 215                 220                 


Val Gly Asp Tyr Gly Tyr Pro Ala Asp Val Leu Phe Ser Ser Arg Leu 
225                 230                 235                 240 


Thr His Phe Ile Trp Lys Ile Cys Gly Gln Ser Leu Ala Asn Lys Tyr 
                245                 250                 255     


Leu Glu Lys Lys Ile Asn Gln Arg Phe Asp His Glu Met Phe Gly Leu 
            260                 265                 270         


Lys Pro Lys His Arg Leu 
        275             


<210>  5486
<211>  464
<212>  PRT
<213>  Homo Sapiens

<400>  5486

Met Thr Lys Lys Arg Ile Ala Val Ile Gly Gly Gly Val Ser Gly Leu 
1               5                   10                  15      


Ser Ser Ile Lys Cys Cys Val Glu Glu Gly Leu Glu Pro Val Cys Phe 
            20                  25                  30          


Glu Arg Thr Asp Asp Ile Gly Gly Leu Trp Arg Phe Gln Glu Asn Pro 
        35                  40                  45              


Glu Glu Gly Arg Ala Ser Ile Tyr Lys Ser Val Ile Ile Asn Thr Ser 
    50                  55                  60                  


Lys Glu Met Met Cys Phe Ser Asp Tyr Pro Ile Pro Asp His Tyr Pro 
65                  70                  75                  80  


Asn Phe Met His Asn Ala Gln Val Leu Glu Tyr Phe Arg Met Tyr Ala 
                85                  90                  95      


Lys Glu Phe Asp Leu Leu Lys Tyr Ile Arg Phe Lys Thr Thr Val Cys 
            100                 105                 110         


Ser Val Lys Lys Gln Pro Asp Phe Ala Thr Ser Gly Gln Trp Glu Val 
        115                 120                 125             


Val Thr Glu Ser Glu Gly Lys Lys Glu Met Asn Val Phe Asp Gly Val 
    130                 135                 140                 


Met Val Cys Thr Gly His His Thr Asn Ala His Leu Pro Leu Glu Ser 
145                 150                 155                 160 


Phe Pro Gly Ile Glu Lys Phe Lys Gly Gln Tyr Phe His Ser Arg Asp 
                165                 170                 175     


Tyr Lys Asn Pro Glu Gly Phe Thr Gly Lys Arg Val Ile Ile Ile Gly 
            180                 185                 190         


Ile Gly Asn Ser Gly Gly Asp Leu Ala Val Glu Ile Ser Gln Thr Ala 
        195                 200                 205             


Lys Gln Val Phe Leu Ser Thr Arg Arg Gly Ala Trp Ile Leu Asn Arg 
    210                 215                 220                 


Val Gly Asp Tyr Gly Tyr Pro Ala Asp Val Leu Phe Ser Ser Arg Leu 
225                 230                 235                 240 


Thr His Phe Ile Trp Lys Ile Cys Gly Gln Ser Leu Ala Asn Lys Tyr 
                245                 250                 255     


Leu Glu Lys Lys Ile Asn Gln Arg Phe Asp His Glu Met Phe Gly Leu 
            260                 265                 270         


Lys Pro Lys His Arg Ala Leu Ser Gln His Pro Thr Leu Asn Asp Asp 
        275                 280                 285             


Leu Pro Asn Arg Ile Ile Ser Gly Leu Val Lys Val Lys Gly Asn Val 
    290                 295                 300                 


Lys Glu Phe Thr Glu Thr Ala Ala Ile Phe Glu Asp Gly Ser Arg Glu 
305                 310                 315                 320 


Asp Asp Ile Asp Ala Val Ile Phe Ala Thr Gly Tyr Ser Phe Asp Phe 
                325                 330                 335     


Pro Phe Leu Glu Asp Ser Val Lys Val Val Lys Asn Lys Ile Ser Leu 
            340                 345                 350         


Tyr Lys Lys Val Phe Pro Pro Asn Leu Glu Arg Pro Thr Leu Ala Ile 
        355                 360                 365             


Ile Gly Leu Ile Gln Pro Leu Gly Ala Ile Met Pro Ile Ser Glu Leu 
    370                 375                 380                 


Gln Gly Arg Trp Ala Thr Gln Val Phe Lys Gly Leu Lys Thr Leu Pro 
385                 390                 395                 400 


Ser Gln Ser Glu Met Met Ala Glu Ile Ser Lys Ala Gln Glu Glu Ile 
                405                 410                 415     


Asp Lys Ser Leu Thr Met Arg Lys Thr Ser Asp Lys Pro Lys Leu Lys 
            420                 425                 430         


Asn Ile Leu Gln Ile Pro Asp Tyr Leu Lys Thr Val Lys Ile Ile Asn 
        435                 440                 445             


Lys Glu Ser Leu Arg Asn Cys Pro Gly Ile Lys Gly Pro Lys Glu Thr 
    450                 455                 460                 


<210>  5487
<211>  376
<212>  PRT
<213>  Homo Sapiens

<400>  5487

Met Gln Trp Thr Ser Leu Leu Leu Leu Ala Gly Leu Phe Ser Leu Ser 
1               5                   10                  15      


Gln Ala Gln Tyr Glu Asp Asp Pro His Trp Trp Phe His Tyr Leu Arg 
            20                  25                  30          


Ser Gln Gln Ser Thr Tyr Tyr Asp Pro Tyr Asp Pro Tyr Pro Tyr Glu 
        35                  40                  45              


Thr Tyr Glu Pro Tyr Pro Tyr Gly Val Asp Glu Gly Pro Ala Tyr Thr 
    50                  55                  60                  


Tyr Gly Ser Pro Ser Pro Pro Asp Pro Arg Asp Cys Pro Gln Glu Cys 
65                  70                  75                  80  


Asp Cys Pro Pro Asn Phe Pro Thr Ala Met Tyr Cys Asp Asn Arg Asn 
                85                  90                  95      


Leu Lys Tyr Leu Pro Phe Val Pro Ser Arg Met Lys Tyr Val Tyr Phe 
            100                 105                 110         


Gln Asn Asn Gln Ile Thr Ser Ile Gln Glu Gly Val Phe Asp Asn Ala 
        115                 120                 125             


Thr Gly Leu Leu Trp Ile Ala Leu His Gly Asn Gln Ile Thr Ser Asp 
    130                 135                 140                 


Lys Val Gly Arg Lys Val Phe Ser Lys Leu Arg His Leu Glu Arg Leu 
145                 150                 155                 160 


Tyr Leu Asp His Asn Asn Leu Thr Arg Met Pro Gly Pro Leu Pro Arg 
                165                 170                 175     


Ser Leu Arg Glu Leu His Leu Asp His Asn Gln Ile Ser Arg Val Pro 
            180                 185                 190         


Asn Asn Ala Leu Glu Gly Leu Glu Asn Leu Thr Ala Leu Tyr Leu Gln 
        195                 200                 205             


His Asn Glu Ile Gln Glu Val Gly Ser Ser Met Arg Gly Leu Arg Ser 
    210                 215                 220                 


Leu Ile Leu Leu Asp Leu Ser Tyr Asn His Leu Arg Lys Val Pro Asp 
225                 230                 235                 240 


Gly Leu Pro Ser Ala Leu Glu Gln Leu Tyr Met Glu His Asn Asn Val 
                245                 250                 255     


Tyr Thr Val Pro Asp Ser Tyr Phe Arg Gly Ala Pro Lys Leu Leu Tyr 
            260                 265                 270         


Val Arg Leu Ser His Asn Ser Leu Thr Asn Asn Gly Leu Ala Ser Asn 
        275                 280                 285             


Thr Phe Asn Ser Ser Ser Leu Leu Glu Leu Asp Leu Ser Tyr Asn Gln 
    290                 295                 300                 


Leu Gln Lys Ile Pro Pro Val Asn Thr Asn Leu Glu Asn Leu Tyr Leu 
305                 310                 315                 320 


Gln Gly Asn Arg Ile Asn Glu Phe Ser Ile Ser Ser Phe Cys Thr Val 
                325                 330                 335     


Val Asp Val Val Asn Phe Ser Lys Leu Gln Val Leu Arg Leu Asp Gly 
            340                 345                 350         


Asn Glu Ile Lys Arg Ser Ala Met Pro Ala Asp Ala Pro Leu Cys Leu 
        355                 360                 365             


Arg Leu Ala Ser Leu Ile Glu Ile 
    370                 375     


<210>  5488
<211>  1103
<212>  PRT
<213>  Homo Sapiens

<400>  5488

Leu Arg Trp Thr Pro Leu Asn Ser Ser Thr Ile Ile Gly Tyr Arg Ile 
1               5                   10                  15      


Thr Val Val Ala Ala Gly Glu Gly Ile Pro Ile Phe Glu Asp Phe Val 
            20                  25                  30          


Asp Ser Ser Val Gly Tyr Tyr Thr Val Thr Gly Leu Glu Pro Gly Ile 
        35                  40                  45              


Asp Tyr Asp Ile Ser Val Ile Thr Leu Ile Asn Gly Gly Glu Ser Ala 
    50                  55                  60                  


Pro Thr Thr Leu Thr Gln Gln Thr Ala Val Pro Pro Pro Thr Asp Leu 
65                  70                  75                  80  


Arg Phe Thr Asn Ile Gly Pro Asp Thr Met Arg Val Thr Trp Ala Pro 
                85                  90                  95      


Pro Pro Ser Ile Asp Leu Thr Asn Phe Leu Val Arg Tyr Ser Pro Val 
            100                 105                 110         


Lys Asn Glu Glu Asp Val Ala Glu Leu Ser Ile Ser Pro Ser Asp Asn 
        115                 120                 125             


Ala Val Val Leu Thr Asn Leu Leu Pro Gly Thr Glu Tyr Val Val Ser 
    130                 135                 140                 


Val Ser Ser Val Tyr Glu Gln His Glu Ser Thr Pro Leu Arg Gly Arg 
145                 150                 155                 160 


Gln Lys Thr Gly Leu Asp Ser Pro Thr Gly Ile Asp Phe Ser Asp Ile 
                165                 170                 175     


Thr Ala Asn Ser Phe Thr Val His Trp Ile Ala Pro Arg Ala Thr Ile 
            180                 185                 190         


Thr Gly Tyr Arg Ile Arg His His Pro Glu His Phe Ser Gly Arg Pro 
        195                 200                 205             


Arg Glu Asp Arg Val Pro His Ser Arg Asn Ser Ile Thr Leu Thr Asn 
    210                 215                 220                 


Leu Thr Pro Gly Thr Glu Tyr Val Val Ser Ile Val Ala Leu Asn Gly 
225                 230                 235                 240 


Arg Glu Glu Ser Pro Leu Leu Ile Gly Gln Gln Ser Thr Val Ser Asp 
                245                 250                 255     


Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu 
            260                 265                 270         


Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr Tyr Arg Ile Thr 
        275                 280                 285             


Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro 
    290                 295                 300                 


Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp 
305                 310                 315                 320 


Tyr Thr Ile Thr Val Tyr Ala Val Thr Gly Arg Gly Asp Ser Pro Ala 
                325                 330                 335     


Ser Ser Lys Pro Ile Ser Ile Asn Tyr Arg Thr Glu Ile Asp Lys Pro 
            340                 345                 350         


Ser Gln Met Gln Val Thr Asp Val Gln Asp Asn Ser Ile Ser Val Lys 
        355                 360                 365             


Trp Leu Pro Ser Ser Ser Pro Val Thr Gly Tyr Arg Val Thr Thr Thr 
    370                 375                 380                 


Pro Lys Asn Gly Pro Gly Pro Thr Lys Thr Lys Thr Ala Gly Pro Asp 
385                 390                 395                 400 


Gln Thr Glu Met Thr Ile Glu Gly Leu Gln Pro Thr Val Glu Tyr Val 
                405                 410                 415     


Val Ser Val Tyr Ala Gln Asn Pro Ser Gly Glu Ser Gln Pro Leu Val 
            420                 425                 430         


Gln Thr Ala Val Thr Thr Ile Pro Ala Pro Thr Asp Leu Lys Phe Thr 
        435                 440                 445             


Gln Val Thr Pro Thr Ser Leu Ser Ala Gln Trp Thr Pro Pro Asn Val 
    450                 455                 460                 


Gln Leu Thr Gly Tyr Arg Val Arg Val Thr Pro Lys Glu Lys Thr Gly 
465                 470                 475                 480 


Pro Met Lys Glu Ile Asn Leu Ala Pro Asp Ser Ser Ser Val Val Val 
                485                 490                 495     


Ser Gly Leu Met Val Ala Thr Lys Tyr Glu Val Ser Val Tyr Ala Leu 
            500                 505                 510         


Lys Asp Thr Leu Thr Ser Arg Pro Ala Gln Gly Val Val Thr Thr Leu 
        515                 520                 525             


Glu Asn Val Ser Pro Pro Arg Arg Ala Arg Val Thr Asp Ala Thr Glu 
    530                 535                 540                 


Thr Thr Ile Thr Ile Ser Trp Arg Thr Lys Thr Glu Thr Ile Thr Gly 
545                 550                 555                 560 


Phe Gln Val Asp Ala Val Pro Ala Asn Gly Gln Thr Pro Ile Gln Arg 
                565                 570                 575     


Thr Ile Lys Pro Asp Val Arg Ser Tyr Thr Ile Thr Gly Leu Gln Pro 
            580                 585                 590         


Gly Thr Asp Tyr Lys Ile Tyr Leu Tyr Thr Leu Asn Asp Asn Ala Arg 
        595                 600                 605             


Ser Ser Pro Val Val Ile Asp Ala Ser Thr Ala Ile Asp Ala Pro Ser 
    610                 615                 620                 


Asn Leu Arg Phe Leu Ala Thr Thr Pro Asn Ser Leu Leu Val Ser Trp 
625                 630                 635                 640 


Gln Pro Pro Arg Ala Arg Ile Thr Gly Tyr Ile Ile Lys Tyr Glu Lys 
                645                 650                 655     


Pro Gly Ser Pro Pro Arg Glu Val Val Pro Arg Pro Arg Pro Gly Val 
            660                 665                 670         


Thr Glu Ala Thr Ile Thr Gly Leu Glu Pro Gly Thr Glu Tyr Thr Ile 
        675                 680                 685             


Tyr Val Ile Ala Leu Lys Asn Asn Gln Lys Ser Glu Pro Leu Ile Gly 
    690                 695                 700                 


Arg Lys Lys Thr Asp Glu Leu Pro Gln Leu Val Thr Leu Pro His Pro 
705                 710                 715                 720 


Asn Leu His Gly Pro Glu Ile Leu Asp Val Pro Ser Thr Val Gln Lys 
                725                 730                 735     


Thr Pro Phe Val Thr His Pro Gly Tyr Asp Thr Gly Asn Gly Ile Gln 
            740                 745                 750         


Leu Pro Gly Thr Ser Gly Gln Gln Pro Ser Val Gly Gln Gln Met Ile 
        755                 760                 765             


Phe Glu Glu His Gly Phe Arg Arg Thr Thr Pro Pro Thr Thr Ala Thr 
    770                 775                 780                 


Pro Ile Arg His Arg Pro Arg Pro Tyr Pro Pro Asn Val Gly Glu Glu 
785                 790                 795                 800 


Ile Gln Ile Gly His Ile Pro Arg Glu Asp Val Asp Tyr His Leu Tyr 
                805                 810                 815     


Pro His Gly Pro Gly Leu Asn Pro Asn Ala Ser Thr Gly Gln Glu Ala 
            820                 825                 830         


Leu Ser Gln Thr Thr Ile Ser Trp Ala Pro Phe Gln Asp Thr Ser Glu 
        835                 840                 845             


Tyr Ile Ile Ser Cys His Pro Val Gly Thr Asp Glu Glu Pro Leu Gln 
    850                 855                 860                 


Phe Arg Val Pro Gly Thr Ser Thr Ser Ala Thr Leu Thr Gly Leu Thr 
865                 870                 875                 880 


Arg Gly Ala Thr Tyr Asn Val Ile Val Glu Ala Leu Lys Asp Gln Gln 
                885                 890                 895     


Arg His Lys Val Arg Glu Glu Val Val Thr Val Gly Asn Ser Val Asn 
            900                 905                 910         


Glu Gly Leu Asn Gln Pro Thr Asp Asp Ser Cys Phe Asp Pro Tyr Thr 
        915                 920                 925             


Val Ser His Tyr Ala Val Gly Asp Glu Trp Glu Arg Met Ser Glu Ser 
    930                 935                 940                 


Gly Phe Lys Leu Leu Cys Gln Cys Leu Gly Phe Gly Ser Gly His Phe 
945                 950                 955                 960 


Arg Cys Asp Ser Ser Arg Trp Cys His Asp Asn Gly Val Asn Tyr Lys 
                965                 970                 975     


Ile Gly Glu Lys Trp Asp Arg Gln Gly Glu Asn Gly Gln Met Met Ser 
            980                 985                 990         


Cys Thr Cys Leu Gly Asn Gly Lys  Gly Glu Phe Lys Cys  Asp Pro His 
        995                 1000                 1005             


Glu Ala  Thr Cys Tyr Asp Asp  Gly Lys Thr Tyr His  Val Gly Glu 
    1010                 1015                 1020             


Gln Trp  Gln Lys Glu Tyr Leu  Gly Ala Ile Cys Ser  Cys Thr Cys 
    1025                 1030                 1035             


Phe Gly  Gly Gln Arg Gly Trp  Arg Cys Asp Asn Cys  Arg Arg Pro 
    1040                 1045                 1050             


Gly Gly  Glu Pro Ser Pro Glu  Gly Thr Thr Gly Gln  Ser Tyr Asn 
    1055                 1060                 1065             


Gln Tyr  Ser Gln Arg Tyr His  Gln Arg Thr Asn Thr  Asn Val Asn 
    1070                 1075                 1080             


Cys Pro  Ile Glu Cys Phe Met  Pro Leu Asp Val Gln  Ala Asp Arg 
    1085                 1090                 1095             


Glu Asp  Ser Arg Glu 
    1100             


<210>  5489
<211>  2355
<212>  PRT
<213>  Homo Sapiens

<400>  5489

Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln 
            20                  25                  30          


Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser 
        35                  40                  45              


Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln 
    50                  55                  60                  


Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly 
65                  70                  75                  80  


Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr 
                85                  90                  95      


Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr 
            100                 105                 110         


Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala 
        115                 120                 125             


Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly 
    130                 135                 140                 


Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr 
145                 150                 155                 160 


Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu 
                165                 170                 175     


Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly 
            180                 185                 190         


Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp 
        195                 200                 205             


Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr 
    210                 215                 220                 


Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr 
225                 230                 235                 240 


Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu 
                245                 250                 255     


Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg 
            260                 265                 270         


His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp 
        275                 280                 285             


Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro 
    290                 295                 300                 


Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met 
305                 310                 315                 320 


Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu 
                325                 330                 335     


Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 
            340                 345                 350         


Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly 
        355                 360                 365             


Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 
    370                 375                 380                 


Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe 
385                 390                 395                 400 


Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn 
                405                 410                 415     


Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr 
            420                 425                 430         


Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr 
        435                 440                 445             


Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala 
    450                 455                 460                 


Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 
465                 470                 475                 480 


Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys 
                485                 490                 495     


Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser 
            500                 505                 510         


Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn 
        515                 520                 525             


Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr 
    530                 535                 540                 


Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln 
545                 550                 555                 560 


Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp 
                565                 570                 575     


Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 
            580                 585                 590         


Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser 
        595                 600                 605             


Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn 
    610                 615                 620                 


Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys 
625                 630                 635                 640 


Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu 
                645                 650                 655     


Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys 
            660                 665                 670         


Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly 
        675                 680                 685             


His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr 
    690                 695                 700                 


Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro 
705                 710                 715                 720 


Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe 
                725                 730                 735     


Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val 
            740                 745                 750         


Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu 
        755                 760                 765             


Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg 
    770                 775                 780                 


Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser 
785                 790                 795                 800 


Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp 
                805                 810                 815     


Thr Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser 
            820                 825                 830         


Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser 
        835                 840                 845             


Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser 
    850                 855                 860                 


Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile 
865                 870                 875                 880 


Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln 
                885                 890                 895     


Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp 
            900                 905                 910         


Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr 
        915                 920                 925             


Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val 
    930                 935                 940                 


Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr 
945                 950                 955                 960 


Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys 
                965                 970                 975     


Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln 
            980                 985                 990         


Gln Thr Thr Lys Leu Asp Ala Pro  Thr Asn Leu Gln Phe  Val Asn Glu 
        995                 1000                 1005             


Thr Asp  Ser Thr Val Leu Val  Arg Trp Thr Pro Pro  Arg Ala Gln 
    1010                 1015                 1020             


Ile Thr  Gly Tyr Arg Leu Thr  Val Gly Leu Thr Arg  Arg Gly Gln 
    1025                 1030                 1035             


Pro Arg  Gln Tyr Asn Val Gly  Pro Ser Val Ser Lys  Tyr Pro Leu 
    1040                 1045                 1050             


Arg Asn  Leu Gln Pro Ala Ser  Glu Tyr Thr Val Ser  Leu Val Ala 
    1055                 1060                 1065             


Ile Lys  Gly Asn Gln Glu Ser  Pro Lys Ala Thr Gly  Val Phe Thr 
    1070                 1075                 1080             


Thr Leu  Gln Pro Gly Ser Ser  Ile Pro Pro Tyr Asn  Thr Glu Val 
    1085                 1090                 1095             


Thr Glu  Thr Thr Ile Val Ile  Thr Trp Thr Pro Ala  Pro Arg Ile 
    1100                 1105                 1110             


Gly Phe  Lys Leu Gly Val Arg  Pro Ser Gln Gly Gly  Glu Ala Pro 
    1115                 1120                 1125             


Arg Glu  Val Thr Ser Asp Ser  Gly Ser Ile Val Val  Ser Gly Leu 
    1130                 1135                 1140             


Thr Pro  Gly Val Glu Tyr Val  Tyr Thr Ile Gln Val  Leu Arg Asp 
    1145                 1150                 1155             


Gly Gln  Glu Arg Asp Ala Pro  Ile Val Asn Lys Val  Val Thr Pro 
    1160                 1165                 1170             


Leu Ser  Pro Pro Thr Asn Leu  His Leu Glu Ala Asn  Pro Asp Thr 
    1175                 1180                 1185             


Gly Val  Leu Thr Val Ser Trp  Glu Arg Ser Thr Thr  Pro Asp Ile 
    1190                 1195                 1200             


Thr Gly  Tyr Arg Ile Thr Thr  Thr Pro Thr Asn Gly  Gln Gln Gly 
    1205                 1210                 1215             


Asn Ser  Leu Glu Glu Val Val  His Ala Asp Gln Ser  Ser Cys Thr 
    1220                 1225                 1230             


Phe Asp  Asn Leu Ser Pro Gly  Leu Glu Tyr Asn Val  Ser Val Tyr 
    1235                 1240                 1245             


Thr Val  Lys Asp Asp Lys Glu  Ser Val Pro Ile Ser  Asp Thr Ile 
    1250                 1255                 1260             


Ile Pro  Ala Val Pro Pro Pro  Thr Asp Leu Arg Phe  Thr Asn Ile 
    1265                 1270                 1275             


Gly Pro  Asp Thr Met Arg Val  Thr Trp Ala Pro Pro  Pro Ser Ile 
    1280                 1285                 1290             


Asp Leu  Thr Asn Phe Leu Val  Arg Tyr Ser Pro Val  Lys Asn Glu 
    1295                 1300                 1305             


Glu Asp  Val Ala Glu Leu Ser  Ile Ser Pro Ser Asp  Asn Ala Val 
    1310                 1315                 1320             


Val Leu  Thr Asn Leu Leu Pro  Gly Thr Glu Tyr Val  Val Ser Val 
    1325                 1330                 1335             


Ser Ser  Val Tyr Glu Gln His  Glu Ser Thr Pro Leu  Arg Gly Arg 
    1340                 1345                 1350             


Gln Lys  Thr Gly Leu Asp Ser  Pro Thr Gly Ile Asp  Phe Ser Asp 
    1355                 1360                 1365             


Ile Thr  Ala Asn Ser Phe Thr  Val His Trp Ile Ala  Pro Arg Ala 
    1370                 1375                 1380             


Thr Ile  Thr Gly Tyr Arg Ile  Arg His His Pro Glu  His Phe Ser 
    1385                 1390                 1395             


Gly Arg  Pro Arg Glu Asp Arg  Val Pro His Ser Arg  Asn Ser Ile 
    1400                 1405                 1410             


Thr Leu  Thr Asn Leu Thr Pro  Gly Thr Glu Tyr Val  Val Ser Ile 
    1415                 1420                 1425             


Val Ala  Leu Asn Gly Arg Glu  Glu Ser Pro Leu Leu  Ile Gly Gln 
    1430                 1435                 1440             


Gln Ser  Thr Val Ser Asp Val  Pro Arg Asp Leu Glu  Val Val Ala 
    1445                 1450                 1455             


Ala Thr  Pro Thr Ser Leu Leu  Ile Ser Trp Asp Ala  Pro Ala Val 
    1460                 1465                 1470             


Thr Val  Arg Tyr Tyr Arg Ile  Thr Tyr Gly Glu Thr  Gly Gly Asn 
    1475                 1480                 1485             


Ser Pro  Val Gln Glu Phe Thr  Val Pro Gly Ser Lys  Ser Thr Ala 
    1490                 1495                 1500             


Thr Ile  Ser Gly Leu Lys Pro  Gly Val Asp Tyr Thr  Ile Thr Val 
    1505                 1510                 1515             


Tyr Ala  Val Thr Gly Arg Gly  Asp Ser Pro Ala Ser  Ser Lys Pro 
    1520                 1525                 1530             


Ile Ser  Ile Asn Tyr Arg Thr  Glu Ile Asp Lys Pro  Ser Gln Met 
    1535                 1540                 1545             


Gln Val  Thr Asp Val Gln Asp  Asn Ser Ile Ser Val  Lys Trp Leu 
    1550                 1555                 1560             


Pro Ser  Ser Ser Pro Val Thr  Gly Tyr Arg Val Thr  Thr Thr Pro 
    1565                 1570                 1575             


Lys Asn  Gly Pro Gly Pro Thr  Lys Thr Lys Thr Ala  Gly Pro Asp 
    1580                 1585                 1590             


Gln Thr  Glu Met Thr Ile Glu  Gly Leu Gln Pro Thr  Val Glu Tyr 
    1595                 1600                 1605             


Val Val  Ser Val Tyr Ala Gln  Asn Pro Ser Gly Glu  Ser Gln Pro 
    1610                 1615                 1620             


Leu Val  Gln Thr Ala Val Thr  Asn Ile Asp Arg Pro  Lys Gly Leu 
    1625                 1630                 1635             


Ala Phe  Thr Asp Val Asp Val  Asp Ser Ile Lys Ile  Ala Trp Glu 
    1640                 1645                 1650             


Ser Pro  Gln Gly Gln Val Ser  Arg Tyr Arg Val Thr  Tyr Ser Ser 
    1655                 1660                 1665             


Pro Glu  Asp Gly Ile His Glu  Leu Phe Pro Ala Pro  Asp Gly Glu 
    1670                 1675                 1680             


Glu Asp  Thr Ala Glu Leu Gln  Gly Leu Arg Pro Gly  Ser Glu Tyr 
    1685                 1690                 1695             


Thr Val  Ser Val Val Ala Leu  His Asp Asp Met Glu  Ser Gln Pro 
    1700                 1705                 1710             


Leu Ile  Gly Thr Gln Ser Thr  Ala Ile Pro Ala Pro  Thr Asp Leu 
    1715                 1720                 1725             


Lys Phe  Thr Gln Val Thr Pro  Thr Ser Leu Ser Ala  Gln Trp Thr 
    1730                 1735                 1740             


Pro Pro  Asn Val Gln Leu Thr  Gly Tyr Arg Val Arg  Val Thr Pro 
    1745                 1750                 1755             


Lys Glu  Lys Thr Gly Pro Met  Lys Glu Ile Asn Leu  Ala Pro Asp 
    1760                 1765                 1770             


Ser Ser  Ser Val Val Val Ser  Gly Leu Met Val Ala  Thr Lys Tyr 
    1775                 1780                 1785             


Glu Val  Ser Val Tyr Ala Leu  Lys Asp Thr Leu Thr  Ser Arg Pro 
    1790                 1795                 1800             


Ala Gln  Gly Val Val Thr Thr  Leu Glu Asn Val Ser  Pro Pro Arg 
    1805                 1810                 1815             


Arg Ala  Arg Val Thr Asp Ala  Thr Glu Thr Thr Ile  Thr Ile Ser 
    1820                 1825                 1830             


Trp Arg  Thr Lys Thr Glu Thr  Ile Thr Gly Phe Gln  Val Asp Ala 
    1835                 1840                 1845             


Val Pro  Ala Asn Gly Gln Thr  Pro Ile Gln Arg Thr  Ile Lys Pro 
    1850                 1855                 1860             


Asp Val  Arg Ser Tyr Thr Ile  Thr Gly Leu Gln Pro  Gly Thr Asp 
    1865                 1870                 1875             


Tyr Lys  Ile Tyr Leu Tyr Thr  Leu Asn Asp Asn Ala  Arg Ser Ser 
    1880                 1885                 1890             


Pro Val  Val Ile Asp Ala Ser  Thr Ala Ile Asp Ala  Pro Ser Asn 
    1895                 1900                 1905             


Leu Arg  Phe Leu Ala Thr Thr  Pro Asn Ser Leu Leu  Val Ser Trp 
    1910                 1915                 1920             


Gln Pro  Pro Arg Ala Arg Ile  Thr Gly Tyr Ile Ile  Lys Tyr Glu 
    1925                 1930                 1935             


Lys Pro  Gly Ser Pro Pro Arg  Glu Val Val Pro Arg  Pro Arg Pro 
    1940                 1945                 1950             


Gly Val  Thr Glu Ala Thr Ile  Thr Gly Leu Glu Pro  Gly Thr Glu 
    1955                 1960                 1965             


Tyr Thr  Ile Tyr Val Ile Ala  Leu Lys Asn Asn Gln  Lys Ser Glu 
    1970                 1975                 1980             


Pro Leu  Ile Gly Arg Lys Lys  Thr Asp Glu Leu Pro  Gln Leu Val 
    1985                 1990                 1995             


Thr Leu  Pro His Pro Asn Leu  His Gly Pro Glu Ile  Leu Asp Val 
    2000                 2005                 2010             


Pro Ser  Thr Val Gln Lys Thr  Pro Phe Val Thr His  Pro Gly Tyr 
    2015                 2020                 2025             


Asp Thr  Gly Asn Gly Ile Gln  Leu Pro Gly Thr Ser  Gly Gln Gln 
    2030                 2035                 2040             


Pro Ser  Val Gly Gln Gln Met  Ile Phe Glu Glu His  Gly Phe Arg 
    2045                 2050                 2055             


Arg Thr  Thr Pro Pro Thr Thr  Ala Thr Pro Ile Arg  His Arg Pro 
    2060                 2065                 2070             


Arg Pro  Tyr Pro Pro Asn Val  Gly Gln Glu Ala Leu  Ser Gln Thr 
    2075                 2080                 2085             


Thr Ile  Ser Trp Ala Pro Phe  Gln Asp Thr Ser Glu  Tyr Ile Ile 
    2090                 2095                 2100             


Ser Cys  His Pro Val Gly Thr  Asp Glu Glu Pro Leu  Gln Phe Arg 
    2105                 2110                 2115             


Val Pro  Gly Thr Ser Thr Ser  Ala Thr Leu Thr Gly  Leu Thr Arg 
    2120                 2125                 2130             


Gly Ala  Thr Tyr Asn Val Ile  Val Glu Ala Leu Lys  Asp Gln Gln 
    2135                 2140                 2145             


Arg His  Lys Val Arg Glu Glu  Val Val Thr Val Gly  Asn Ser Val 
    2150                 2155                 2160             


Asn Glu  Gly Leu Asn Gln Pro  Thr Asp Asp Ser Cys  Phe Asp Pro 
    2165                 2170                 2175             


Tyr Thr  Val Ser His Tyr Ala  Val Gly Asp Glu Trp  Glu Arg Met 
    2180                 2185                 2190             


Ser Glu  Ser Gly Phe Lys Leu  Leu Cys Gln Cys Leu  Gly Phe Gly 
    2195                 2200                 2205             


Ser Gly  His Phe Arg Cys Asp  Ser Ser Arg Trp Cys  His Asp Asn 
    2210                 2215                 2220             


Gly Val  Asn Tyr Lys Ile Gly  Glu Lys Trp Asp Arg  Gln Gly Glu 
    2225                 2230                 2235             


Asn Gly  Gln Met Met Ser Cys  Thr Cys Leu Gly Asn  Gly Lys Gly 
    2240                 2245                 2250             


Glu Phe  Lys Cys Asp Pro His  Glu Ala Thr Cys Tyr  Asp Asp Gly 
    2255                 2260                 2265             


Lys Thr  Tyr His Val Gly Glu  Gln Trp Gln Lys Glu  Tyr Leu Gly 
    2270                 2275                 2280             


Ala Ile  Cys Ser Cys Thr Cys  Phe Gly Gly Gln Arg  Gly Trp Arg 
    2285                 2290                 2295             


Cys Asp  Asn Cys Arg Arg Pro  Gly Gly Glu Pro Ser  Pro Glu Gly 
    2300                 2305                 2310             


Thr Thr  Gly Gln Ser Tyr Asn  Gln Tyr Ser Gln Arg  Tyr His Gln 
    2315                 2320                 2325             


Arg Thr  Asn Thr Asn Val Asn  Cys Pro Ile Glu Cys  Phe Met Pro 
    2330                 2335                 2340             


Leu Asp  Val Gln Ala Asp Arg  Glu Asp Ser Arg Glu  
    2345                 2350                 2355 


<210>  5490
<211>  2477
<212>  PRT
<213>  Homo Sapiens

<400>  5490

Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln 
            20                  25                  30          


Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser 
        35                  40                  45              


Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln 
    50                  55                  60                  


Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly 
65                  70                  75                  80  


Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr 
                85                  90                  95      


Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr 
            100                 105                 110         


Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala 
        115                 120                 125             


Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly 
    130                 135                 140                 


Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr 
145                 150                 155                 160 


Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu 
                165                 170                 175     


Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly 
            180                 185                 190         


Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp 
        195                 200                 205             


Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr 
    210                 215                 220                 


Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr 
225                 230                 235                 240 


Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu 
                245                 250                 255     


Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg 
            260                 265                 270         


His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp 
        275                 280                 285             


Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro 
    290                 295                 300                 


Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met 
305                 310                 315                 320 


Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu 
                325                 330                 335     


Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 
            340                 345                 350         


Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly 
        355                 360                 365             


Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 
    370                 375                 380                 


Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe 
385                 390                 395                 400 


Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn 
                405                 410                 415     


Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr 
            420                 425                 430         


Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr 
        435                 440                 445             


Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala 
    450                 455                 460                 


Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 
465                 470                 475                 480 


Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys 
                485                 490                 495     


Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser 
            500                 505                 510         


Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn 
        515                 520                 525             


Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr 
    530                 535                 540                 


Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln 
545                 550                 555                 560 


Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp 
                565                 570                 575     


Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 
            580                 585                 590         


Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser 
        595                 600                 605             


Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn 
    610                 615                 620                 


Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys 
625                 630                 635                 640 


Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu 
                645                 650                 655     


Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys 
            660                 665                 670         


Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly 
        675                 680                 685             


His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr 
    690                 695                 700                 


Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro 
705                 710                 715                 720 


Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe 
                725                 730                 735     


Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val 
            740                 745                 750         


Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu 
        755                 760                 765             


Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg 
    770                 775                 780                 


Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser 
785                 790                 795                 800 


Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp 
                805                 810                 815     


Thr Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser 
            820                 825                 830         


Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser 
        835                 840                 845             


Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser 
    850                 855                 860                 


Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile 
865                 870                 875                 880 


Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln 
                885                 890                 895     


Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp 
            900                 905                 910         


Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr 
        915                 920                 925             


Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val 
    930                 935                 940                 


Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr 
945                 950                 955                 960 


Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys 
                965                 970                 975     


Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln 
            980                 985                 990         


Gln Thr Thr Lys Leu Asp Ala Pro  Thr Asn Leu Gln Phe  Val Asn Glu 
        995                 1000                 1005             


Thr Asp  Ser Thr Val Leu Val  Arg Trp Thr Pro Pro  Arg Ala Gln 
    1010                 1015                 1020             


Ile Thr  Gly Tyr Arg Leu Thr  Val Gly Leu Thr Arg  Arg Gly Gln 
    1025                 1030                 1035             


Pro Arg  Gln Tyr Asn Val Gly  Pro Ser Val Ser Lys  Tyr Pro Leu 
    1040                 1045                 1050             


Arg Asn  Leu Gln Pro Ala Ser  Glu Tyr Thr Val Ser  Leu Val Ala 
    1055                 1060                 1065             


Ile Lys  Gly Asn Gln Glu Ser  Pro Lys Ala Thr Gly  Val Phe Thr 
    1070                 1075                 1080             


Thr Leu  Gln Pro Gly Ser Ser  Ile Pro Pro Tyr Asn  Thr Glu Val 
    1085                 1090                 1095             


Thr Glu  Thr Thr Ile Val Ile  Thr Trp Thr Pro Ala  Pro Arg Ile 
    1100                 1105                 1110             


Gly Phe  Lys Leu Gly Val Arg  Pro Ser Gln Gly Gly  Glu Ala Pro 
    1115                 1120                 1125             


Arg Glu  Val Thr Ser Asp Ser  Gly Ser Ile Val Val  Ser Gly Leu 
    1130                 1135                 1140             


Thr Pro  Gly Val Glu Tyr Val  Tyr Thr Ile Gln Val  Leu Arg Asp 
    1145                 1150                 1155             


Gly Gln  Glu Arg Asp Ala Pro  Ile Val Asn Lys Val  Val Thr Pro 
    1160                 1165                 1170             


Leu Ser  Pro Pro Thr Asn Leu  His Leu Glu Ala Asn  Pro Asp Thr 
    1175                 1180                 1185             


Gly Val  Leu Thr Val Ser Trp  Glu Arg Ser Thr Thr  Pro Asp Ile 
    1190                 1195                 1200             


Thr Gly  Tyr Arg Ile Thr Thr  Thr Pro Thr Asn Gly  Gln Gln Gly 
    1205                 1210                 1215             


Asn Ser  Leu Glu Glu Val Val  His Ala Asp Gln Ser  Ser Cys Thr 
    1220                 1225                 1230             


Phe Asp  Asn Leu Ser Pro Gly  Leu Glu Tyr Asn Val  Ser Val Tyr 
    1235                 1240                 1245             


Thr Val  Lys Asp Asp Lys Glu  Ser Val Pro Ile Ser  Asp Thr Ile 
    1250                 1255                 1260             


Ile Pro  Glu Val Pro Gln Leu  Thr Asp Leu Ser Phe  Val Asp Ile 
    1265                 1270                 1275             


Thr Asp  Ser Ser Ile Gly Leu  Arg Trp Thr Pro Leu  Asn Ser Ser 
    1280                 1285                 1290             


Thr Ile  Ile Gly Tyr Arg Ile  Thr Val Val Ala Ala  Gly Glu Gly 
    1295                 1300                 1305             


Ile Pro  Ile Phe Glu Asp Phe  Val Asp Ser Ser Val  Gly Tyr Tyr 
    1310                 1315                 1320             


Thr Val  Thr Gly Leu Glu Pro  Gly Ile Asp Tyr Asp  Ile Ser Val 
    1325                 1330                 1335             


Ile Thr  Leu Ile Asn Gly Gly  Glu Ser Ala Pro Thr  Thr Leu Thr 
    1340                 1345                 1350             


Gln Gln  Thr Ala Val Pro Pro  Pro Thr Asp Leu Arg  Phe Thr Asn 
    1355                 1360                 1365             


Ile Gly  Pro Asp Thr Met Arg  Val Thr Trp Ala Pro  Pro Pro Ser 
    1370                 1375                 1380             


Ile Asp  Leu Thr Asn Phe Leu  Val Arg Tyr Ser Pro  Val Lys Asn 
    1385                 1390                 1395             


Glu Glu  Asp Val Ala Glu Leu  Ser Ile Ser Pro Ser  Asp Asn Ala 
    1400                 1405                 1410             


Val Val  Leu Thr Asn Leu Leu  Pro Gly Thr Glu Tyr  Val Val Ser 
    1415                 1420                 1425             


Val Ser  Ser Val Tyr Glu Gln  His Glu Ser Thr Pro  Leu Arg Gly 
    1430                 1435                 1440             


Arg Gln  Lys Thr Gly Leu Asp  Ser Pro Thr Gly Ile  Asp Phe Ser 
    1445                 1450                 1455             


Asp Ile  Thr Ala Asn Ser Phe  Thr Val His Trp Ile  Ala Pro Arg 
    1460                 1465                 1470             


Ala Thr  Ile Thr Gly Tyr Arg  Ile Arg His His Pro  Glu His Phe 
    1475                 1480                 1485             


Ser Gly  Arg Pro Arg Glu Asp  Arg Val Pro His Ser  Arg Asn Ser 
    1490                 1495                 1500             


Ile Thr  Leu Thr Asn Leu Thr  Pro Gly Thr Glu Tyr  Val Val Ser 
    1505                 1510                 1515             


Ile Val  Ala Leu Asn Gly Arg  Glu Glu Ser Pro Leu  Leu Ile Gly 
    1520                 1525                 1530             


Gln Gln  Ser Thr Val Ser Asp  Val Pro Arg Asp Leu  Glu Val Val 
    1535                 1540                 1545             


Ala Ala  Thr Pro Thr Ser Leu  Leu Ile Ser Trp Asp  Ala Pro Ala 
    1550                 1555                 1560             


Val Thr  Val Arg Tyr Tyr Arg  Ile Thr Tyr Gly Glu  Thr Gly Gly 
    1565                 1570                 1575             


Asn Ser  Pro Val Gln Glu Phe  Thr Val Pro Gly Ser  Lys Ser Thr 
    1580                 1585                 1590             


Ala Thr  Ile Ser Gly Leu Lys  Pro Gly Val Asp Tyr  Thr Ile Thr 
    1595                 1600                 1605             


Val Tyr  Ala Val Thr Gly Arg  Gly Asp Ser Pro Ala  Ser Ser Lys 
    1610                 1615                 1620             


Pro Ile  Ser Ile Asn Tyr Arg  Thr Glu Ile Asp Lys  Pro Ser Gln 
    1625                 1630                 1635             


Met Gln  Val Thr Asp Val Gln  Asp Asn Ser Ile Ser  Val Lys Trp 
    1640                 1645                 1650             


Leu Pro  Ser Ser Ser Pro Val  Thr Gly Tyr Arg Val  Thr Thr Thr 
    1655                 1660                 1665             


Pro Lys  Asn Gly Pro Gly Pro  Thr Lys Thr Lys Thr  Ala Gly Pro 
    1670                 1675                 1680             


Asp Gln  Thr Glu Met Thr Ile  Glu Gly Leu Gln Pro  Thr Val Glu 
    1685                 1690                 1695             


Tyr Val  Val Ser Val Tyr Ala  Gln Asn Pro Ser Gly  Glu Ser Gln 
    1700                 1705                 1710             


Pro Leu  Val Gln Thr Ala Val  Thr Asn Ile Asp Arg  Pro Lys Gly 
    1715                 1720                 1725             


Leu Ala  Phe Thr Asp Val Asp  Val Asp Ser Ile Lys  Ile Ala Trp 
    1730                 1735                 1740             


Glu Ser  Pro Gln Gly Gln Val  Ser Arg Tyr Arg Val  Thr Tyr Ser 
    1745                 1750                 1755             


Ser Pro  Glu Asp Gly Ile His  Glu Leu Phe Pro Ala  Pro Asp Gly 
    1760                 1765                 1770             


Glu Glu  Asp Thr Ala Glu Leu  Gln Gly Leu Arg Pro  Gly Ser Glu 
    1775                 1780                 1785             


Tyr Thr  Val Ser Val Val Ala  Leu His Asp Asp Met  Glu Ser Gln 
    1790                 1795                 1800             


Pro Leu  Ile Gly Thr Gln Ser  Thr Ala Ile Pro Ala  Pro Thr Asp 
    1805                 1810                 1815             


Leu Lys  Phe Thr Gln Val Thr  Pro Thr Ser Leu Ser  Ala Gln Trp 
    1820                 1825                 1830             


Thr Pro  Pro Asn Val Gln Leu  Thr Gly Tyr Arg Val  Arg Val Thr 
    1835                 1840                 1845             


Pro Lys  Glu Lys Thr Gly Pro  Met Lys Glu Ile Asn  Leu Ala Pro 
    1850                 1855                 1860             


Asp Ser  Ser Ser Val Val Val  Ser Gly Leu Met Val  Ala Thr Lys 
    1865                 1870                 1875             


Tyr Glu  Val Ser Val Tyr Ala  Leu Lys Asp Thr Leu  Thr Ser Arg 
    1880                 1885                 1890             


Pro Ala  Gln Gly Val Val Thr  Thr Leu Glu Asn Val  Ser Pro Pro 
    1895                 1900                 1905             


Arg Arg  Ala Arg Val Thr Asp  Ala Thr Glu Thr Thr  Ile Thr Ile 
    1910                 1915                 1920             


Ser Trp  Arg Thr Lys Thr Glu  Thr Ile Thr Gly Phe  Gln Val Asp 
    1925                 1930                 1935             


Ala Val  Pro Ala Asn Gly Gln  Thr Pro Ile Gln Arg  Thr Ile Lys 
    1940                 1945                 1950             


Pro Asp  Val Arg Ser Tyr Thr  Ile Thr Gly Leu Gln  Pro Gly Thr 
    1955                 1960                 1965             


Asp Tyr  Lys Ile Tyr Leu Tyr  Thr Leu Asn Asp Asn  Ala Arg Ser 
    1970                 1975                 1980             


Ser Pro  Val Val Ile Asp Ala  Ser Thr Ala Ile Asp  Ala Pro Ser 
    1985                 1990                 1995             


Asn Leu  Arg Phe Leu Ala Thr  Thr Pro Asn Ser Leu  Leu Val Ser 
    2000                 2005                 2010             


Trp Gln  Pro Pro Arg Ala Arg  Ile Thr Gly Tyr Ile  Ile Lys Tyr 
    2015                 2020                 2025             


Glu Lys  Pro Gly Ser Pro Pro  Arg Glu Val Val Pro  Arg Pro Arg 
    2030                 2035                 2040             


Pro Gly  Val Thr Glu Ala Thr  Ile Thr Gly Leu Glu  Pro Gly Thr 
    2045                 2050                 2055             


Glu Tyr  Thr Ile Tyr Val Ile  Ala Leu Lys Asn Asn  Gln Lys Ser 
    2060                 2065                 2070             


Glu Pro  Leu Ile Gly Arg Lys  Lys Thr Asp Glu Leu  Pro Gln Leu 
    2075                 2080                 2085             


Val Thr  Leu Pro His Pro Asn  Leu His Gly Pro Glu  Ile Leu Asp 
    2090                 2095                 2100             


Val Pro  Ser Thr Val Gln Lys  Thr Pro Phe Val Thr  His Pro Gly 
    2105                 2110                 2115             


Tyr Asp  Thr Gly Asn Gly Ile  Gln Leu Pro Gly Thr  Ser Gly Gln 
    2120                 2125                 2130             


Gln Pro  Ser Val Gly Gln Gln  Met Ile Phe Glu Glu  His Gly Phe 
    2135                 2140                 2145             


Arg Arg  Thr Thr Pro Pro Thr  Thr Ala Thr Pro Ile  Arg His Arg 
    2150                 2155                 2160             


Pro Arg  Pro Tyr Pro Pro Asn  Val Gly Glu Glu Ile  Gln Ile Gly 
    2165                 2170                 2175             


His Ile  Pro Arg Glu Asp Val  Asp Tyr His Leu Tyr  Pro His Gly 
    2180                 2185                 2190             


Pro Gly  Leu Asn Pro Asn Ala  Ser Thr Gly Gln Glu  Ala Leu Ser 
    2195                 2200                 2205             


Gln Thr  Thr Ile Ser Trp Ala  Pro Phe Gln Asp Thr  Ser Glu Tyr 
    2210                 2215                 2220             


Ile Ile  Ser Cys His Pro Val  Gly Thr Asp Glu Glu  Pro Leu Gln 
    2225                 2230                 2235             


Phe Arg  Val Pro Gly Thr Ser  Thr Ser Ala Thr Leu  Thr Gly Leu 
    2240                 2245                 2250             


Thr Arg  Gly Ala Thr Tyr Asn  Val Ile Val Glu Ala  Leu Lys Asp 
    2255                 2260                 2265             


Gln Gln  Arg His Lys Val Arg  Glu Glu Val Val Thr  Val Gly Asn 
    2270                 2275                 2280             


Ser Val  Asn Glu Gly Leu Asn  Gln Pro Thr Asp Asp  Ser Cys Phe 
    2285                 2290                 2295             


Asp Pro  Tyr Thr Val Ser His  Tyr Ala Val Gly Asp  Glu Trp Glu 
    2300                 2305                 2310             


Arg Met  Ser Glu Ser Gly Phe  Lys Leu Leu Cys Gln  Cys Leu Gly 
    2315                 2320                 2325             


Phe Gly  Ser Gly His Phe Arg  Cys Asp Ser Ser Arg  Trp Cys His 
    2330                 2335                 2340             


Asp Asn  Gly Val Asn Tyr Lys  Ile Gly Glu Lys Trp  Asp Arg Gln 
    2345                 2350                 2355             


Gly Glu  Asn Gly Gln Met Met  Ser Cys Thr Cys Leu  Gly Asn Gly 
    2360                 2365                 2370             


Lys Gly  Glu Phe Lys Cys Asp  Pro His Glu Ala Thr  Cys Tyr Asp 
    2375                 2380                 2385             


Asp Gly  Lys Thr Tyr His Val  Gly Glu Gln Trp Gln  Lys Glu Tyr 
    2390                 2395                 2400             


Leu Gly  Ala Ile Cys Ser Cys  Thr Cys Phe Gly Gly  Gln Arg Gly 
    2405                 2410                 2415             


Trp Arg  Cys Asp Asn Cys Arg  Arg Pro Gly Gly Glu  Pro Ser Pro 
    2420                 2425                 2430             


Glu Gly  Thr Thr Gly Gln Ser  Tyr Asn Gln Tyr Ser  Gln Arg Tyr 
    2435                 2440                 2445             


His Gln  Arg Thr Asn Thr Asn  Val Asn Cys Pro Ile  Glu Cys Phe 
    2450                 2455                 2460             


Met Pro  Leu Asp Val Gln Ala  Asp Arg Glu Asp Ser  Arg Glu 
    2465                 2470                 2475         


<210>  5491
<211>  2176
<212>  PRT
<213>  Homo Sapiens

<400>  5491

Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln 
            20                  25                  30          


Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser 
        35                  40                  45              


Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln 
    50                  55                  60                  


Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly 
65                  70                  75                  80  


Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr 
                85                  90                  95      


Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr 
            100                 105                 110         


Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala 
        115                 120                 125             


Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly 
    130                 135                 140                 


Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr 
145                 150                 155                 160 


Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu 
                165                 170                 175     


Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly 
            180                 185                 190         


Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp 
        195                 200                 205             


Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr 
    210                 215                 220                 


Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr 
225                 230                 235                 240 


Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu 
                245                 250                 255     


Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg 
            260                 265                 270         


His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp 
        275                 280                 285             


Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro 
    290                 295                 300                 


Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met 
305                 310                 315                 320 


Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu 
                325                 330                 335     


Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 
            340                 345                 350         


Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly 
        355                 360                 365             


Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 
    370                 375                 380                 


Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe 
385                 390                 395                 400 


Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn 
                405                 410                 415     


Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr 
            420                 425                 430         


Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr 
        435                 440                 445             


Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala 
    450                 455                 460                 


Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 
465                 470                 475                 480 


Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys 
                485                 490                 495     


Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser 
            500                 505                 510         


Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn 
        515                 520                 525             


Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr 
    530                 535                 540                 


Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln 
545                 550                 555                 560 


Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp 
                565                 570                 575     


Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 
            580                 585                 590         


Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser 
        595                 600                 605             


Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn 
    610                 615                 620                 


Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys 
625                 630                 635                 640 


Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu 
                645                 650                 655     


Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys 
            660                 665                 670         


Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly 
        675                 680                 685             


His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr 
    690                 695                 700                 


Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro 
705                 710                 715                 720 


Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe 
                725                 730                 735     


Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val 
            740                 745                 750         


Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu 
        755                 760                 765             


Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg 
    770                 775                 780                 


Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser 
785                 790                 795                 800 


Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp 
                805                 810                 815     


Thr Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser 
            820                 825                 830         


Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser 
        835                 840                 845             


Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser 
    850                 855                 860                 


Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile 
865                 870                 875                 880 


Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln 
                885                 890                 895     


Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp 
            900                 905                 910         


Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr 
        915                 920                 925             


Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val 
    930                 935                 940                 


Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr 
945                 950                 955                 960 


Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys 
                965                 970                 975     


Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln 
            980                 985                 990         


Gln Thr Thr Lys Leu Asp Ala Pro  Thr Asn Leu Gln Phe  Val Asn Glu 
        995                 1000                 1005             


Thr Asp  Ser Thr Val Leu Val  Arg Trp Thr Pro Pro  Arg Ala Gln 
    1010                 1015                 1020             


Ile Thr  Gly Tyr Arg Leu Thr  Val Gly Leu Thr Arg  Arg Gly Gln 
    1025                 1030                 1035             


Pro Arg  Gln Tyr Asn Val Gly  Pro Ser Val Ser Lys  Tyr Pro Leu 
    1040                 1045                 1050             


Arg Asn  Leu Gln Pro Ala Ser  Glu Tyr Thr Val Ser  Leu Val Ala 
    1055                 1060                 1065             


Ile Lys  Gly Asn Gln Glu Ser  Pro Lys Ala Thr Gly  Val Phe Thr 
    1070                 1075                 1080             


Thr Leu  Gln Pro Gly Ser Ser  Ile Pro Pro Tyr Asn  Thr Glu Val 
    1085                 1090                 1095             


Thr Glu  Thr Thr Ile Val Ile  Thr Trp Thr Pro Ala  Pro Arg Ile 
    1100                 1105                 1110             


Gly Phe  Lys Leu Gly Val Arg  Pro Ser Gln Gly Gly  Glu Ala Pro 
    1115                 1120                 1125             


Arg Glu  Val Thr Ser Asp Ser  Gly Ser Ile Val Val  Ser Gly Leu 
    1130                 1135                 1140             


Thr Pro  Gly Val Glu Tyr Val  Tyr Thr Ile Gln Val  Leu Arg Asp 
    1145                 1150                 1155             


Gly Gln  Glu Arg Asp Ala Pro  Ile Val Asn Lys Val  Val Thr Pro 
    1160                 1165                 1170             


Leu Ser  Pro Pro Thr Asn Leu  His Leu Glu Ala Asn  Pro Asp Thr 
    1175                 1180                 1185             


Gly Val  Leu Thr Val Ser Trp  Glu Arg Ser Thr Thr  Pro Asp Ile 
    1190                 1195                 1200             


Thr Gly  Tyr Arg Ile Thr Thr  Thr Pro Thr Asn Gly  Gln Gln Gly 
    1205                 1210                 1215             


Asn Ser  Leu Glu Glu Val Val  His Ala Asp Gln Ser  Ser Cys Thr 
    1220                 1225                 1230             


Phe Asp  Asn Leu Ser Pro Gly  Leu Glu Tyr Asn Val  Ser Val Tyr 
    1235                 1240                 1245             


Thr Val  Lys Asp Asp Lys Glu  Ser Val Pro Ile Ser  Asp Thr Ile 
    1250                 1255                 1260             


Ile Pro  Ala Val Pro Pro Pro  Thr Asp Leu Arg Phe  Thr Asn Ile 
    1265                 1270                 1275             


Gly Pro  Asp Thr Met Arg Val  Thr Trp Ala Pro Pro  Pro Ser Ile 
    1280                 1285                 1290             


Asp Leu  Thr Asn Phe Leu Val  Arg Tyr Ser Pro Val  Lys Asn Glu 
    1295                 1300                 1305             


Glu Asp  Val Ala Glu Leu Ser  Ile Ser Pro Ser Asp  Asn Ala Val 
    1310                 1315                 1320             


Val Leu  Thr Asn Leu Leu Pro  Gly Thr Glu Tyr Val  Val Ser Val 
    1325                 1330                 1335             


Ser Ser  Val Tyr Glu Gln His  Glu Ser Thr Pro Leu  Arg Gly Arg 
    1340                 1345                 1350             


Gln Lys  Thr Gly Leu Asp Ser  Pro Thr Gly Ile Asp  Phe Ser Asp 
    1355                 1360                 1365             


Ile Thr  Ala Asn Ser Phe Thr  Val His Trp Ile Ala  Pro Arg Ala 
    1370                 1375                 1380             


Thr Ile  Thr Gly Tyr Arg Ile  Arg His His Pro Glu  His Phe Ser 
    1385                 1390                 1395             


Gly Arg  Pro Arg Glu Asp Arg  Val Pro His Ser Arg  Asn Ser Ile 
    1400                 1405                 1410             


Thr Leu  Thr Asn Leu Thr Pro  Gly Thr Glu Tyr Val  Val Ser Ile 
    1415                 1420                 1425             


Val Ala  Leu Asn Gly Arg Glu  Glu Ser Pro Leu Leu  Ile Gly Gln 
    1430                 1435                 1440             


Gln Ser  Thr Val Ser Asp Val  Pro Arg Asp Leu Glu  Val Val Ala 
    1445                 1450                 1455             


Ala Thr  Pro Thr Ser Leu Leu  Ile Ser Trp Asp Ala  Pro Ala Val 
    1460                 1465                 1470             


Thr Val  Arg Tyr Tyr Arg Ile  Thr Tyr Gly Glu Thr  Gly Gly Asn 
    1475                 1480                 1485             


Ser Pro  Val Gln Glu Phe Thr  Val Pro Gly Ser Lys  Ser Thr Ala 
    1490                 1495                 1500             


Thr Ile  Ser Gly Leu Lys Pro  Gly Val Asp Tyr Thr  Ile Thr Val 
    1505                 1510                 1515             


Tyr Ala  Val Thr Gly Arg Gly  Asp Ser Pro Ala Ser  Ser Lys Pro 
    1520                 1525                 1530             


Ile Ser  Ile Asn Tyr Arg Thr  Glu Ile Asp Lys Pro  Ser Gln Met 
    1535                 1540                 1545             


Gln Val  Thr Asp Val Gln Asp  Asn Ser Ile Ser Val  Lys Trp Leu 
    1550                 1555                 1560             


Pro Ser  Ser Ser Pro Val Thr  Gly Tyr Arg Val Thr  Thr Thr Pro 
    1565                 1570                 1575             


Lys Asn  Gly Pro Gly Pro Thr  Lys Thr Lys Thr Ala  Gly Pro Asp 
    1580                 1585                 1590             


Gln Thr  Glu Met Thr Ile Glu  Gly Leu Gln Pro Thr  Val Glu Tyr 
    1595                 1600                 1605             


Val Val  Ser Val Tyr Ala Gln  Asn Pro Ser Gly Glu  Ser Gln Pro 
    1610                 1615                 1620             


Leu Val  Gln Thr Ala Val Thr  Thr Ile Pro Ala Pro  Thr Asp Leu 
    1625                 1630                 1635             


Lys Phe  Thr Gln Val Thr Pro  Thr Ser Leu Ser Ala  Gln Trp Thr 
    1640                 1645                 1650             


Pro Pro  Asn Val Gln Leu Thr  Gly Tyr Arg Val Arg  Val Thr Pro 
    1655                 1660                 1665             


Lys Glu  Lys Thr Gly Pro Met  Lys Glu Ile Asn Leu  Ala Pro Asp 
    1670                 1675                 1680             


Ser Ser  Ser Val Val Val Ser  Gly Leu Met Val Ala  Thr Lys Tyr 
    1685                 1690                 1695             


Glu Val  Ser Val Tyr Ala Leu  Lys Asp Thr Leu Thr  Ser Arg Pro 
    1700                 1705                 1710             


Ala Gln  Gly Val Val Thr Thr  Leu Glu Asn Val Ser  Pro Pro Arg 
    1715                 1720                 1725             


Arg Ala  Arg Val Thr Asp Ala  Thr Glu Thr Thr Ile  Thr Ile Ser 
    1730                 1735                 1740             


Trp Arg  Thr Lys Thr Glu Thr  Ile Thr Gly Phe Gln  Val Asp Ala 
    1745                 1750                 1755             


Val Pro  Ala Asn Gly Gln Thr  Pro Ile Gln Arg Thr  Ile Lys Pro 
    1760                 1765                 1770             


Asp Val  Arg Ser Tyr Thr Ile  Thr Gly Leu Gln Pro  Gly Thr Asp 
    1775                 1780                 1785             


Tyr Lys  Ile Tyr Leu Tyr Thr  Leu Asn Asp Asn Ala  Arg Ser Ser 
    1790                 1795                 1800             


Pro Val  Val Ile Asp Ala Ser  Thr Ala Ile Asp Ala  Pro Ser Asn 
    1805                 1810                 1815             


Leu Arg  Phe Leu Ala Thr Thr  Pro Asn Ser Leu Leu  Val Ser Trp 
    1820                 1825                 1830             


Gln Pro  Pro Arg Ala Arg Ile  Thr Gly Tyr Ile Ile  Lys Tyr Glu 
    1835                 1840                 1845             


Lys Pro  Gly Ser Pro Pro Arg  Glu Val Val Pro Arg  Pro Arg Pro 
    1850                 1855                 1860             


Gly Val  Thr Glu Ala Thr Ile  Thr Gly Leu Glu Pro  Gly Thr Glu 
    1865                 1870                 1875             


Tyr Thr  Ile Tyr Val Ile Ala  Leu Lys Asn Asn Gln  Lys Ser Glu 
    1880                 1885                 1890             


Pro Leu  Ile Gly Arg Lys Lys  Thr Gly Gln Glu Ala  Leu Ser Gln 
    1895                 1900                 1905             


Thr Thr  Ile Ser Trp Ala Pro  Phe Gln Asp Thr Ser  Glu Tyr Ile 
    1910                 1915                 1920             


Ile Ser  Cys His Pro Val Gly  Thr Asp Glu Glu Pro  Leu Gln Phe 
    1925                 1930                 1935             


Arg Val  Pro Gly Thr Ser Thr  Ser Ala Thr Leu Thr  Gly Leu Thr 
    1940                 1945                 1950             


Arg Gly  Ala Thr Tyr Asn Val  Ile Val Glu Ala Leu  Lys Asp Gln 
    1955                 1960                 1965             


Gln Arg  His Lys Val Arg Glu  Glu Val Val Thr Val  Gly Asn Ser 
    1970                 1975                 1980             


Val Asn  Glu Gly Leu Asn Gln  Pro Thr Asp Asp Ser  Cys Phe Asp 
    1985                 1990                 1995             


Pro Tyr  Thr Val Ser His Tyr  Ala Val Gly Asp Glu  Trp Glu Arg 
    2000                 2005                 2010             


Met Ser  Glu Ser Gly Phe Lys  Leu Leu Cys Gln Cys  Leu Gly Phe 
    2015                 2020                 2025             


Gly Ser  Gly His Phe Arg Cys  Asp Ser Ser Arg Trp  Cys His Asp 
    2030                 2035                 2040             


Asn Gly  Val Asn Tyr Lys Ile  Gly Glu Lys Trp Asp  Arg Gln Gly 
    2045                 2050                 2055             


Glu Asn  Gly Gln Met Met Ser  Cys Thr Cys Leu Gly  Asn Gly Lys 
    2060                 2065                 2070             


Gly Glu  Phe Lys Cys Asp Pro  His Glu Ala Thr Cys  Tyr Asp Asp 
    2075                 2080                 2085             


Gly Lys  Thr Tyr His Val Gly  Glu Gln Trp Gln Lys  Glu Tyr Leu 
    2090                 2095                 2100             


Gly Ala  Ile Cys Ser Cys Thr  Cys Phe Gly Gly Gln  Arg Gly Trp 
    2105                 2110                 2115             


Arg Cys  Asp Asn Cys Arg Arg  Pro Gly Gly Glu Pro  Ser Pro Glu 
    2120                 2125                 2130             


Gly Thr  Thr Gly Gln Ser Tyr  Asn Gln Tyr Ser Gln  Arg Tyr His 
    2135                 2140                 2145             


Gln Arg  Thr Asn Thr Asn Val  Asn Cys Pro Ile Glu  Cys Phe Met 
    2150                 2155                 2160             


Pro Leu  Asp Val Gln Ala Asp  Arg Glu Asp Ser Arg  Glu 
    2165                 2170                 2175     


<210>  5492
<211>  2386
<212>  PRT
<213>  Homo Sapiens

<400>  5492

Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln 
            20                  25                  30          


Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser 
        35                  40                  45              


Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln 
    50                  55                  60                  


Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly 
65                  70                  75                  80  


Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr 
                85                  90                  95      


Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr 
            100                 105                 110         


Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala 
        115                 120                 125             


Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly 
    130                 135                 140                 


Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr 
145                 150                 155                 160 


Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu 
                165                 170                 175     


Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly 
            180                 185                 190         


Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp 
        195                 200                 205             


Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr 
    210                 215                 220                 


Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr 
225                 230                 235                 240 


Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu 
                245                 250                 255     


Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg 
            260                 265                 270         


His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp 
        275                 280                 285             


Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro 
    290                 295                 300                 


Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met 
305                 310                 315                 320 


Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu 
                325                 330                 335     


Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 
            340                 345                 350         


Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly 
        355                 360                 365             


Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 
    370                 375                 380                 


Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe 
385                 390                 395                 400 


Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn 
                405                 410                 415     


Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr 
            420                 425                 430         


Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr 
        435                 440                 445             


Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala 
    450                 455                 460                 


Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 
465                 470                 475                 480 


Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys 
                485                 490                 495     


Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser 
            500                 505                 510         


Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn 
        515                 520                 525             


Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr 
    530                 535                 540                 


Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln 
545                 550                 555                 560 


Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp 
                565                 570                 575     


Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 
            580                 585                 590         


Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser 
        595                 600                 605             


Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn 
    610                 615                 620                 


Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys 
625                 630                 635                 640 


Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu 
                645                 650                 655     


Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys 
            660                 665                 670         


Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly 
        675                 680                 685             


His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr 
    690                 695                 700                 


Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro 
705                 710                 715                 720 


Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe 
                725                 730                 735     


Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val 
            740                 745                 750         


Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu 
        755                 760                 765             


Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg 
    770                 775                 780                 


Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser 
785                 790                 795                 800 


Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp 
                805                 810                 815     


Thr Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser 
            820                 825                 830         


Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser 
        835                 840                 845             


Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser 
    850                 855                 860                 


Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile 
865                 870                 875                 880 


Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln 
                885                 890                 895     


Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp 
            900                 905                 910         


Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr 
        915                 920                 925             


Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val 
    930                 935                 940                 


Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr 
945                 950                 955                 960 


Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys 
                965                 970                 975     


Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln 
            980                 985                 990         


Gln Thr Thr Lys Leu Asp Ala Pro  Thr Asn Leu Gln Phe  Val Asn Glu 
        995                 1000                 1005             


Thr Asp  Ser Thr Val Leu Val  Arg Trp Thr Pro Pro  Arg Ala Gln 
    1010                 1015                 1020             


Ile Thr  Gly Tyr Arg Leu Thr  Val Gly Leu Thr Arg  Arg Gly Gln 
    1025                 1030                 1035             


Pro Arg  Gln Tyr Asn Val Gly  Pro Ser Val Ser Lys  Tyr Pro Leu 
    1040                 1045                 1050             


Arg Asn  Leu Gln Pro Ala Ser  Glu Tyr Thr Val Ser  Leu Val Ala 
    1055                 1060                 1065             


Ile Lys  Gly Asn Gln Glu Ser  Pro Lys Ala Thr Gly  Val Phe Thr 
    1070                 1075                 1080             


Thr Leu  Gln Pro Gly Ser Ser  Ile Pro Pro Tyr Asn  Thr Glu Val 
    1085                 1090                 1095             


Thr Glu  Thr Thr Ile Val Ile  Thr Trp Thr Pro Ala  Pro Arg Ile 
    1100                 1105                 1110             


Gly Phe  Lys Leu Gly Val Arg  Pro Ser Gln Gly Gly  Glu Ala Pro 
    1115                 1120                 1125             


Arg Glu  Val Thr Ser Asp Ser  Gly Ser Ile Val Val  Ser Gly Leu 
    1130                 1135                 1140             


Thr Pro  Gly Val Glu Tyr Val  Tyr Thr Ile Gln Val  Leu Arg Asp 
    1145                 1150                 1155             


Gly Gln  Glu Arg Asp Ala Pro  Ile Val Asn Lys Val  Val Thr Pro 
    1160                 1165                 1170             


Leu Ser  Pro Pro Thr Asn Leu  His Leu Glu Ala Asn  Pro Asp Thr 
    1175                 1180                 1185             


Gly Val  Leu Thr Val Ser Trp  Glu Arg Ser Thr Thr  Pro Asp Ile 
    1190                 1195                 1200             


Thr Gly  Tyr Arg Ile Thr Thr  Thr Pro Thr Asn Gly  Gln Gln Gly 
    1205                 1210                 1215             


Asn Ser  Leu Glu Glu Val Val  His Ala Asp Gln Ser  Ser Cys Thr 
    1220                 1225                 1230             


Phe Asp  Asn Leu Ser Pro Gly  Leu Glu Tyr Asn Val  Ser Val Tyr 
    1235                 1240                 1245             


Thr Val  Lys Asp Asp Lys Glu  Ser Val Pro Ile Ser  Asp Thr Ile 
    1250                 1255                 1260             


Ile Pro  Ala Val Pro Pro Pro  Thr Asp Leu Arg Phe  Thr Asn Ile 
    1265                 1270                 1275             


Gly Pro  Asp Thr Met Arg Val  Thr Trp Ala Pro Pro  Pro Ser Ile 
    1280                 1285                 1290             


Asp Leu  Thr Asn Phe Leu Val  Arg Tyr Ser Pro Val  Lys Asn Glu 
    1295                 1300                 1305             


Glu Asp  Val Ala Glu Leu Ser  Ile Ser Pro Ser Asp  Asn Ala Val 
    1310                 1315                 1320             


Val Leu  Thr Asn Leu Leu Pro  Gly Thr Glu Tyr Val  Val Ser Val 
    1325                 1330                 1335             


Ser Ser  Val Tyr Glu Gln His  Glu Ser Thr Pro Leu  Arg Gly Arg 
    1340                 1345                 1350             


Gln Lys  Thr Gly Leu Asp Ser  Pro Thr Gly Ile Asp  Phe Ser Asp 
    1355                 1360                 1365             


Ile Thr  Ala Asn Ser Phe Thr  Val His Trp Ile Ala  Pro Arg Ala 
    1370                 1375                 1380             


Thr Ile  Thr Gly Tyr Arg Ile  Arg His His Pro Glu  His Phe Ser 
    1385                 1390                 1395             


Gly Arg  Pro Arg Glu Asp Arg  Val Pro His Ser Arg  Asn Ser Ile 
    1400                 1405                 1410             


Thr Leu  Thr Asn Leu Thr Pro  Gly Thr Glu Tyr Val  Val Ser Ile 
    1415                 1420                 1425             


Val Ala  Leu Asn Gly Arg Glu  Glu Ser Pro Leu Leu  Ile Gly Gln 
    1430                 1435                 1440             


Gln Ser  Thr Val Ser Asp Val  Pro Arg Asp Leu Glu  Val Val Ala 
    1445                 1450                 1455             


Ala Thr  Pro Thr Ser Leu Leu  Ile Ser Trp Asp Ala  Pro Ala Val 
    1460                 1465                 1470             


Thr Val  Arg Tyr Tyr Arg Ile  Thr Tyr Gly Glu Thr  Gly Gly Asn 
    1475                 1480                 1485             


Ser Pro  Val Gln Glu Phe Thr  Val Pro Gly Ser Lys  Ser Thr Ala 
    1490                 1495                 1500             


Thr Ile  Ser Gly Leu Lys Pro  Gly Val Asp Tyr Thr  Ile Thr Val 
    1505                 1510                 1515             


Tyr Ala  Val Thr Gly Arg Gly  Asp Ser Pro Ala Ser  Ser Lys Pro 
    1520                 1525                 1530             


Ile Ser  Ile Asn Tyr Arg Thr  Glu Ile Asp Lys Pro  Ser Gln Met 
    1535                 1540                 1545             


Gln Val  Thr Asp Val Gln Asp  Asn Ser Ile Ser Val  Lys Trp Leu 
    1550                 1555                 1560             


Pro Ser  Ser Ser Pro Val Thr  Gly Tyr Arg Val Thr  Thr Thr Pro 
    1565                 1570                 1575             


Lys Asn  Gly Pro Gly Pro Thr  Lys Thr Lys Thr Ala  Gly Pro Asp 
    1580                 1585                 1590             


Gln Thr  Glu Met Thr Ile Glu  Gly Leu Gln Pro Thr  Val Glu Tyr 
    1595                 1600                 1605             


Val Val  Ser Val Tyr Ala Gln  Asn Pro Ser Gly Glu  Ser Gln Pro 
    1610                 1615                 1620             


Leu Val  Gln Thr Ala Val Thr  Asn Ile Asp Arg Pro  Lys Gly Leu 
    1625                 1630                 1635             


Ala Phe  Thr Asp Val Asp Val  Asp Ser Ile Lys Ile  Ala Trp Glu 
    1640                 1645                 1650             


Ser Pro  Gln Gly Gln Val Ser  Arg Tyr Arg Val Thr  Tyr Ser Ser 
    1655                 1660                 1665             


Pro Glu  Asp Gly Ile His Glu  Leu Phe Pro Ala Pro  Asp Gly Glu 
    1670                 1675                 1680             


Glu Asp  Thr Ala Glu Leu Gln  Gly Leu Arg Pro Gly  Ser Glu Tyr 
    1685                 1690                 1695             


Thr Val  Ser Val Val Ala Leu  His Asp Asp Met Glu  Ser Gln Pro 
    1700                 1705                 1710             


Leu Ile  Gly Thr Gln Ser Thr  Ala Ile Pro Ala Pro  Thr Asp Leu 
    1715                 1720                 1725             


Lys Phe  Thr Gln Val Thr Pro  Thr Ser Leu Ser Ala  Gln Trp Thr 
    1730                 1735                 1740             


Pro Pro  Asn Val Gln Leu Thr  Gly Tyr Arg Val Arg  Val Thr Pro 
    1745                 1750                 1755             


Lys Glu  Lys Thr Gly Pro Met  Lys Glu Ile Asn Leu  Ala Pro Asp 
    1760                 1765                 1770             


Ser Ser  Ser Val Val Val Ser  Gly Leu Met Val Ala  Thr Lys Tyr 
    1775                 1780                 1785             


Glu Val  Ser Val Tyr Ala Leu  Lys Asp Thr Leu Thr  Ser Arg Pro 
    1790                 1795                 1800             


Ala Gln  Gly Val Val Thr Thr  Leu Glu Asn Val Ser  Pro Pro Arg 
    1805                 1810                 1815             


Arg Ala  Arg Val Thr Asp Ala  Thr Glu Thr Thr Ile  Thr Ile Ser 
    1820                 1825                 1830             


Trp Arg  Thr Lys Thr Glu Thr  Ile Thr Gly Phe Gln  Val Asp Ala 
    1835                 1840                 1845             


Val Pro  Ala Asn Gly Gln Thr  Pro Ile Gln Arg Thr  Ile Lys Pro 
    1850                 1855                 1860             


Asp Val  Arg Ser Tyr Thr Ile  Thr Gly Leu Gln Pro  Gly Thr Asp 
    1865                 1870                 1875             


Tyr Lys  Ile Tyr Leu Tyr Thr  Leu Asn Asp Asn Ala  Arg Ser Ser 
    1880                 1885                 1890             


Pro Val  Val Ile Asp Ala Ser  Thr Ala Ile Asp Ala  Pro Ser Asn 
    1895                 1900                 1905             


Leu Arg  Phe Leu Ala Thr Thr  Pro Asn Ser Leu Leu  Val Ser Trp 
    1910                 1915                 1920             


Gln Pro  Pro Arg Ala Arg Ile  Thr Gly Tyr Ile Ile  Lys Tyr Glu 
    1925                 1930                 1935             


Lys Pro  Gly Ser Pro Pro Arg  Glu Val Val Pro Arg  Pro Arg Pro 
    1940                 1945                 1950             


Gly Val  Thr Glu Ala Thr Ile  Thr Gly Leu Glu Pro  Gly Thr Glu 
    1955                 1960                 1965             


Tyr Thr  Ile Tyr Val Ile Ala  Leu Lys Asn Asn Gln  Lys Ser Glu 
    1970                 1975                 1980             


Pro Leu  Ile Gly Arg Lys Lys  Thr Asp Glu Leu Pro  Gln Leu Val 
    1985                 1990                 1995             


Thr Leu  Pro His Pro Asn Leu  His Gly Pro Glu Ile  Leu Asp Val 
    2000                 2005                 2010             


Pro Ser  Thr Val Gln Lys Thr  Pro Phe Val Thr His  Pro Gly Tyr 
    2015                 2020                 2025             


Asp Thr  Gly Asn Gly Ile Gln  Leu Pro Gly Thr Ser  Gly Gln Gln 
    2030                 2035                 2040             


Pro Ser  Val Gly Gln Gln Met  Ile Phe Glu Glu His  Gly Phe Arg 
    2045                 2050                 2055             


Arg Thr  Thr Pro Pro Thr Thr  Ala Thr Pro Ile Arg  His Arg Pro 
    2060                 2065                 2070             


Arg Pro  Tyr Pro Pro Asn Val  Gly Glu Glu Ile Gln  Ile Gly His 
    2075                 2080                 2085             


Ile Pro  Arg Glu Asp Val Asp  Tyr His Leu Tyr Pro  His Gly Pro 
    2090                 2095                 2100             


Gly Leu  Asn Pro Asn Ala Ser  Thr Gly Gln Glu Ala  Leu Ser Gln 
    2105                 2110                 2115             


Thr Thr  Ile Ser Trp Ala Pro  Phe Gln Asp Thr Ser  Glu Tyr Ile 
    2120                 2125                 2130             


Ile Ser  Cys His Pro Val Gly  Thr Asp Glu Glu Pro  Leu Gln Phe 
    2135                 2140                 2145             


Arg Val  Pro Gly Thr Ser Thr  Ser Ala Thr Leu Thr  Gly Leu Thr 
    2150                 2155                 2160             


Arg Gly  Ala Thr Tyr Asn Val  Ile Val Glu Ala Leu  Lys Asp Gln 
    2165                 2170                 2175             


Gln Arg  His Lys Val Arg Glu  Glu Val Val Thr Val  Gly Asn Ser 
    2180                 2185                 2190             


Val Asn  Glu Gly Leu Asn Gln  Pro Thr Asp Asp Ser  Cys Phe Asp 
    2195                 2200                 2205             


Pro Tyr  Thr Val Ser His Tyr  Ala Val Gly Asp Glu  Trp Glu Arg 
    2210                 2215                 2220             


Met Ser  Glu Ser Gly Phe Lys  Leu Leu Cys Gln Cys  Leu Gly Phe 
    2225                 2230                 2235             


Gly Ser  Gly His Phe Arg Cys  Asp Ser Ser Arg Trp  Cys His Asp 
    2240                 2245                 2250             


Asn Gly  Val Asn Tyr Lys Ile  Gly Glu Lys Trp Asp  Arg Gln Gly 
    2255                 2260                 2265             


Glu Asn  Gly Gln Met Met Ser  Cys Thr Cys Leu Gly  Asn Gly Lys 
    2270                 2275                 2280             


Gly Glu  Phe Lys Cys Asp Pro  His Glu Ala Thr Cys  Tyr Asp Asp 
    2285                 2290                 2295             


Gly Lys  Thr Tyr His Val Gly  Glu Gln Trp Gln Lys  Glu Tyr Leu 
    2300                 2305                 2310             


Gly Ala  Ile Cys Ser Cys Thr  Cys Phe Gly Gly Gln  Arg Gly Trp 
    2315                 2320                 2325             


Arg Cys  Asp Asn Cys Arg Arg  Pro Gly Gly Glu Pro  Ser Pro Glu 
    2330                 2335                 2340             


Gly Thr  Thr Gly Gln Ser Tyr  Asn Gln Tyr Ser Gln  Arg Tyr His 
    2345                 2350                 2355             


Gln Arg  Thr Asn Thr Asn Val  Asn Cys Pro Ile Glu  Cys Phe Met 
    2360                 2365                 2370             


Pro Leu  Asp Val Gln Ala Asp  Arg Glu Asp Ser Arg  Glu 
    2375                 2380                 2385     


<210>  5493
<211>  2296
<212>  PRT
<213>  Homo Sapiens

<400>  5493

Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln 
            20                  25                  30          


Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser 
        35                  40                  45              


Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln 
    50                  55                  60                  


Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly 
65                  70                  75                  80  


Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr 
                85                  90                  95      


Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr 
            100                 105                 110         


Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala 
        115                 120                 125             


Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly 
    130                 135                 140                 


Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr 
145                 150                 155                 160 


Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu 
                165                 170                 175     


Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly 
            180                 185                 190         


Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp 
        195                 200                 205             


Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr 
    210                 215                 220                 


Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr 
225                 230                 235                 240 


Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu 
                245                 250                 255     


Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg 
            260                 265                 270         


His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp 
        275                 280                 285             


Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro 
    290                 295                 300                 


Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met 
305                 310                 315                 320 


Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu 
                325                 330                 335     


Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 
            340                 345                 350         


Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly 
        355                 360                 365             


Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 
    370                 375                 380                 


Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe 
385                 390                 395                 400 


Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn 
                405                 410                 415     


Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr 
            420                 425                 430         


Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr 
        435                 440                 445             


Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala 
    450                 455                 460                 


Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 
465                 470                 475                 480 


Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys 
                485                 490                 495     


Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser 
            500                 505                 510         


Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn 
        515                 520                 525             


Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr 
    530                 535                 540                 


Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln 
545                 550                 555                 560 


Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp 
                565                 570                 575     


Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 
            580                 585                 590         


Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser 
        595                 600                 605             


Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn 
    610                 615                 620                 


Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys 
625                 630                 635                 640 


Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu 
                645                 650                 655     


Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys 
            660                 665                 670         


Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly 
        675                 680                 685             


His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr 
    690                 695                 700                 


Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro 
705                 710                 715                 720 


Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe 
                725                 730                 735     


Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val 
            740                 745                 750         


Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu 
        755                 760                 765             


Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg 
    770                 775                 780                 


Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser 
785                 790                 795                 800 


Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp 
                805                 810                 815     


Thr Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser 
            820                 825                 830         


Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser 
        835                 840                 845             


Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser 
    850                 855                 860                 


Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile 
865                 870                 875                 880 


Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln 
                885                 890                 895     


Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp 
            900                 905                 910         


Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr 
        915                 920                 925             


Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val 
    930                 935                 940                 


Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr 
945                 950                 955                 960 


Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys 
                965                 970                 975     


Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln 
            980                 985                 990         


Gln Thr Thr Lys Leu Asp Ala Pro  Thr Asn Leu Gln Phe  Val Asn Glu 
        995                 1000                 1005             


Thr Asp  Ser Thr Val Leu Val  Arg Trp Thr Pro Pro  Arg Ala Gln 
    1010                 1015                 1020             


Ile Thr  Gly Tyr Arg Leu Thr  Val Gly Leu Thr Arg  Arg Gly Gln 
    1025                 1030                 1035             


Pro Arg  Gln Tyr Asn Val Gly  Pro Ser Val Ser Lys  Tyr Pro Leu 
    1040                 1045                 1050             


Arg Asn  Leu Gln Pro Ala Ser  Glu Tyr Thr Val Ser  Leu Val Ala 
    1055                 1060                 1065             


Ile Lys  Gly Asn Gln Glu Ser  Pro Lys Ala Thr Gly  Val Phe Thr 
    1070                 1075                 1080             


Thr Leu  Gln Pro Gly Ser Ser  Ile Pro Pro Tyr Asn  Thr Glu Val 
    1085                 1090                 1095             


Thr Glu  Thr Thr Ile Val Ile  Thr Trp Thr Pro Ala  Pro Arg Ile 
    1100                 1105                 1110             


Gly Phe  Lys Leu Gly Val Arg  Pro Ser Gln Gly Gly  Glu Ala Pro 
    1115                 1120                 1125             


Arg Glu  Val Thr Ser Asp Ser  Gly Ser Ile Val Val  Ser Gly Leu 
    1130                 1135                 1140             


Thr Pro  Gly Val Glu Tyr Val  Tyr Thr Ile Gln Val  Leu Arg Asp 
    1145                 1150                 1155             


Gly Gln  Glu Arg Asp Ala Pro  Ile Val Asn Lys Val  Val Thr Pro 
    1160                 1165                 1170             


Leu Ser  Pro Pro Thr Asn Leu  His Leu Glu Ala Asn  Pro Asp Thr 
    1175                 1180                 1185             


Gly Val  Leu Thr Val Ser Trp  Glu Arg Ser Thr Thr  Pro Asp Ile 
    1190                 1195                 1200             


Thr Gly  Tyr Arg Ile Thr Thr  Thr Pro Thr Asn Gly  Gln Gln Gly 
    1205                 1210                 1215             


Asn Ser  Leu Glu Glu Val Val  His Ala Asp Gln Ser  Ser Cys Thr 
    1220                 1225                 1230             


Phe Asp  Asn Leu Ser Pro Gly  Leu Glu Tyr Asn Val  Ser Val Tyr 
    1235                 1240                 1245             


Thr Val  Lys Asp Asp Lys Glu  Ser Val Pro Ile Ser  Asp Thr Ile 
    1250                 1255                 1260             


Ile Pro  Ala Val Pro Pro Pro  Thr Asp Leu Arg Phe  Thr Asn Ile 
    1265                 1270                 1275             


Gly Pro  Asp Thr Met Arg Val  Thr Trp Ala Pro Pro  Pro Ser Ile 
    1280                 1285                 1290             


Asp Leu  Thr Asn Phe Leu Val  Arg Tyr Ser Pro Val  Lys Asn Glu 
    1295                 1300                 1305             


Glu Asp  Val Ala Glu Leu Ser  Ile Ser Pro Ser Asp  Asn Ala Val 
    1310                 1315                 1320             


Val Leu  Thr Asn Leu Leu Pro  Gly Thr Glu Tyr Val  Val Ser Val 
    1325                 1330                 1335             


Ser Ser  Val Tyr Glu Gln His  Glu Ser Thr Pro Leu  Arg Gly Arg 
    1340                 1345                 1350             


Gln Lys  Thr Gly Leu Asp Ser  Pro Thr Gly Ile Asp  Phe Ser Asp 
    1355                 1360                 1365             


Ile Thr  Ala Asn Ser Phe Thr  Val His Trp Ile Ala  Pro Arg Ala 
    1370                 1375                 1380             


Thr Ile  Thr Gly Tyr Arg Ile  Arg His His Pro Glu  His Phe Ser 
    1385                 1390                 1395             


Gly Arg  Pro Arg Glu Asp Arg  Val Pro His Ser Arg  Asn Ser Ile 
    1400                 1405                 1410             


Thr Leu  Thr Asn Leu Thr Pro  Gly Thr Glu Tyr Val  Val Ser Ile 
    1415                 1420                 1425             


Val Ala  Leu Asn Gly Arg Glu  Glu Ser Pro Leu Leu  Ile Gly Gln 
    1430                 1435                 1440             


Gln Ser  Thr Val Ser Asp Val  Pro Arg Asp Leu Glu  Val Val Ala 
    1445                 1450                 1455             


Ala Thr  Pro Thr Ser Leu Leu  Ile Ser Trp Asp Ala  Pro Ala Val 
    1460                 1465                 1470             


Thr Val  Arg Tyr Tyr Arg Ile  Thr Tyr Gly Glu Thr  Gly Gly Asn 
    1475                 1480                 1485             


Ser Pro  Val Gln Glu Phe Thr  Val Pro Gly Ser Lys  Ser Thr Ala 
    1490                 1495                 1500             


Thr Ile  Ser Gly Leu Lys Pro  Gly Val Asp Tyr Thr  Ile Thr Val 
    1505                 1510                 1515             


Tyr Ala  Val Thr Gly Arg Gly  Asp Ser Pro Ala Ser  Ser Lys Pro 
    1520                 1525                 1530             


Ile Ser  Ile Asn Tyr Arg Thr  Glu Ile Asp Lys Pro  Ser Gln Met 
    1535                 1540                 1545             


Gln Val  Thr Asp Val Gln Asp  Asn Ser Ile Ser Val  Lys Trp Leu 
    1550                 1555                 1560             


Pro Ser  Ser Ser Pro Val Thr  Gly Tyr Arg Val Thr  Thr Thr Pro 
    1565                 1570                 1575             


Lys Asn  Gly Pro Gly Pro Thr  Lys Thr Lys Thr Ala  Gly Pro Asp 
    1580                 1585                 1590             


Gln Thr  Glu Met Thr Ile Glu  Gly Leu Gln Pro Thr  Val Glu Tyr 
    1595                 1600                 1605             


Val Val  Ser Val Tyr Ala Gln  Asn Pro Ser Gly Glu  Ser Gln Pro 
    1610                 1615                 1620             


Leu Val  Gln Thr Ala Val Thr  Thr Ile Pro Ala Pro  Thr Asp Leu 
    1625                 1630                 1635             


Lys Phe  Thr Gln Val Thr Pro  Thr Ser Leu Ser Ala  Gln Trp Thr 
    1640                 1645                 1650             


Pro Pro  Asn Val Gln Leu Thr  Gly Tyr Arg Val Arg  Val Thr Pro 
    1655                 1660                 1665             


Lys Glu  Lys Thr Gly Pro Met  Lys Glu Ile Asn Leu  Ala Pro Asp 
    1670                 1675                 1680             


Ser Ser  Ser Val Val Val Ser  Gly Leu Met Val Ala  Thr Lys Tyr 
    1685                 1690                 1695             


Glu Val  Ser Val Tyr Ala Leu  Lys Asp Thr Leu Thr  Ser Arg Pro 
    1700                 1705                 1710             


Ala Gln  Gly Val Val Thr Thr  Leu Glu Asn Val Ser  Pro Pro Arg 
    1715                 1720                 1725             


Arg Ala  Arg Val Thr Asp Ala  Thr Glu Thr Thr Ile  Thr Ile Ser 
    1730                 1735                 1740             


Trp Arg  Thr Lys Thr Glu Thr  Ile Thr Gly Phe Gln  Val Asp Ala 
    1745                 1750                 1755             


Val Pro  Ala Asn Gly Gln Thr  Pro Ile Gln Arg Thr  Ile Lys Pro 
    1760                 1765                 1770             


Asp Val  Arg Ser Tyr Thr Ile  Thr Gly Leu Gln Pro  Gly Thr Asp 
    1775                 1780                 1785             


Tyr Lys  Ile Tyr Leu Tyr Thr  Leu Asn Asp Asn Ala  Arg Ser Ser 
    1790                 1795                 1800             


Pro Val  Val Ile Asp Ala Ser  Thr Ala Ile Asp Ala  Pro Ser Asn 
    1805                 1810                 1815             


Leu Arg  Phe Leu Ala Thr Thr  Pro Asn Ser Leu Leu  Val Ser Trp 
    1820                 1825                 1830             


Gln Pro  Pro Arg Ala Arg Ile  Thr Gly Tyr Ile Ile  Lys Tyr Glu 
    1835                 1840                 1845             


Lys Pro  Gly Ser Pro Pro Arg  Glu Val Val Pro Arg  Pro Arg Pro 
    1850                 1855                 1860             


Gly Val  Thr Glu Ala Thr Ile  Thr Gly Leu Glu Pro  Gly Thr Glu 
    1865                 1870                 1875             


Tyr Thr  Ile Tyr Val Ile Ala  Leu Lys Asn Asn Gln  Lys Ser Glu 
    1880                 1885                 1890             


Pro Leu  Ile Gly Arg Lys Lys  Thr Asp Glu Leu Pro  Gln Leu Val 
    1895                 1900                 1905             


Thr Leu  Pro His Pro Asn Leu  His Gly Pro Glu Ile  Leu Asp Val 
    1910                 1915                 1920             


Pro Ser  Thr Val Gln Lys Thr  Pro Phe Val Thr His  Pro Gly Tyr 
    1925                 1930                 1935             


Asp Thr  Gly Asn Gly Ile Gln  Leu Pro Gly Thr Ser  Gly Gln Gln 
    1940                 1945                 1950             


Pro Ser  Val Gly Gln Gln Met  Ile Phe Glu Glu His  Gly Phe Arg 
    1955                 1960                 1965             


Arg Thr  Thr Pro Pro Thr Thr  Ala Thr Pro Ile Arg  His Arg Pro 
    1970                 1975                 1980             


Arg Pro  Tyr Pro Pro Asn Val  Gly Glu Glu Ile Gln  Ile Gly His 
    1985                 1990                 1995             


Ile Pro  Arg Glu Asp Val Asp  Tyr His Leu Tyr Pro  His Gly Pro 
    2000                 2005                 2010             


Gly Leu  Asn Pro Asn Ala Ser  Thr Gly Gln Glu Ala  Leu Ser Gln 
    2015                 2020                 2025             


Thr Thr  Ile Ser Trp Ala Pro  Phe Gln Asp Thr Ser  Glu Tyr Ile 
    2030                 2035                 2040             


Ile Ser  Cys His Pro Val Gly  Thr Asp Glu Glu Pro  Leu Gln Phe 
    2045                 2050                 2055             


Arg Val  Pro Gly Thr Ser Thr  Ser Ala Thr Leu Thr  Gly Leu Thr 
    2060                 2065                 2070             


Arg Gly  Ala Thr Tyr Asn Val  Ile Val Glu Ala Leu  Lys Asp Gln 
    2075                 2080                 2085             


Gln Arg  His Lys Val Arg Glu  Glu Val Val Thr Val  Gly Asn Ser 
    2090                 2095                 2100             


Val Asn  Glu Gly Leu Asn Gln  Pro Thr Asp Asp Ser  Cys Phe Asp 
    2105                 2110                 2115             


Pro Tyr  Thr Val Ser His Tyr  Ala Val Gly Asp Glu  Trp Glu Arg 
    2120                 2125                 2130             


Met Ser  Glu Ser Gly Phe Lys  Leu Leu Cys Gln Cys  Leu Gly Phe 
    2135                 2140                 2145             


Gly Ser  Gly His Phe Arg Cys  Asp Ser Ser Arg Trp  Cys His Asp 
    2150                 2155                 2160             


Asn Gly  Val Asn Tyr Lys Ile  Gly Glu Lys Trp Asp  Arg Gln Gly 
    2165                 2170                 2175             


Glu Asn  Gly Gln Met Met Ser  Cys Thr Cys Leu Gly  Asn Gly Lys 
    2180                 2185                 2190             


Gly Glu  Phe Lys Cys Asp Pro  His Glu Ala Thr Cys  Tyr Asp Asp 
    2195                 2200                 2205             


Gly Lys  Thr Tyr His Val Gly  Glu Gln Trp Gln Lys  Glu Tyr Leu 
    2210                 2215                 2220             


Gly Ala  Ile Cys Ser Cys Thr  Cys Phe Gly Gly Gln  Arg Gly Trp 
    2225                 2230                 2235             


Arg Cys  Asp Asn Cys Arg Arg  Pro Gly Gly Glu Pro  Ser Pro Glu 
    2240                 2245                 2250             


Gly Thr  Thr Gly Gln Ser Tyr  Asn Gln Tyr Ser Gln  Arg Tyr His 
    2255                 2260                 2265             


Gln Arg  Thr Asn Thr Asn Val  Asn Cys Pro Ile Glu  Cys Phe Met 
    2270                 2275                 2280             


Pro Leu  Asp Val Gln Ala Asp  Arg Glu Asp Ser Arg  Glu 
    2285                 2290                 2295     


<210>  5494
<211>  2446
<212>  PRT
<213>  Homo Sapiens

<400>  5494

Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln 
            20                  25                  30          


Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser 
        35                  40                  45              


Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln 
    50                  55                  60                  


Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly 
65                  70                  75                  80  


Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr 
                85                  90                  95      


Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr 
            100                 105                 110         


Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala 
        115                 120                 125             


Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly 
    130                 135                 140                 


Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr 
145                 150                 155                 160 


Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu 
                165                 170                 175     


Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly 
            180                 185                 190         


Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp 
        195                 200                 205             


Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr 
    210                 215                 220                 


Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr 
225                 230                 235                 240 


Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu 
                245                 250                 255     


Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg 
            260                 265                 270         


His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp 
        275                 280                 285             


Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro 
    290                 295                 300                 


Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met 
305                 310                 315                 320 


Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu 
                325                 330                 335     


Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 
            340                 345                 350         


Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly 
        355                 360                 365             


Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 
    370                 375                 380                 


Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe 
385                 390                 395                 400 


Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn 
                405                 410                 415     


Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr 
            420                 425                 430         


Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr 
        435                 440                 445             


Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala 
    450                 455                 460                 


Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 
465                 470                 475                 480 


Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys 
                485                 490                 495     


Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser 
            500                 505                 510         


Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn 
        515                 520                 525             


Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr 
    530                 535                 540                 


Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln 
545                 550                 555                 560 


Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp 
                565                 570                 575     


Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 
            580                 585                 590         


Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser 
        595                 600                 605             


Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn 
    610                 615                 620                 


Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys 
625                 630                 635                 640 


Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu 
                645                 650                 655     


Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys 
            660                 665                 670         


Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly 
        675                 680                 685             


His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr 
    690                 695                 700                 


Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro 
705                 710                 715                 720 


Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe 
                725                 730                 735     


Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val 
            740                 745                 750         


Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu 
        755                 760                 765             


Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg 
    770                 775                 780                 


Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser 
785                 790                 795                 800 


Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp 
                805                 810                 815     


Thr Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser 
            820                 825                 830         


Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser 
        835                 840                 845             


Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser 
    850                 855                 860                 


Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile 
865                 870                 875                 880 


Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln 
                885                 890                 895     


Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp 
            900                 905                 910         


Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr 
        915                 920                 925             


Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val 
    930                 935                 940                 


Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr 
945                 950                 955                 960 


Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys 
                965                 970                 975     


Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln 
            980                 985                 990         


Gln Thr Thr Lys Leu Asp Ala Pro  Thr Asn Leu Gln Phe  Val Asn Glu 
        995                 1000                 1005             


Thr Asp  Ser Thr Val Leu Val  Arg Trp Thr Pro Pro  Arg Ala Gln 
    1010                 1015                 1020             


Ile Thr  Gly Tyr Arg Leu Thr  Val Gly Leu Thr Arg  Arg Gly Gln 
    1025                 1030                 1035             


Pro Arg  Gln Tyr Asn Val Gly  Pro Ser Val Ser Lys  Tyr Pro Leu 
    1040                 1045                 1050             


Arg Asn  Leu Gln Pro Ala Ser  Glu Tyr Thr Val Ser  Leu Val Ala 
    1055                 1060                 1065             


Ile Lys  Gly Asn Gln Glu Ser  Pro Lys Ala Thr Gly  Val Phe Thr 
    1070                 1075                 1080             


Thr Leu  Gln Pro Gly Ser Ser  Ile Pro Pro Tyr Asn  Thr Glu Val 
    1085                 1090                 1095             


Thr Glu  Thr Thr Ile Val Ile  Thr Trp Thr Pro Ala  Pro Arg Ile 
    1100                 1105                 1110             


Gly Phe  Lys Leu Gly Val Arg  Pro Ser Gln Gly Gly  Glu Ala Pro 
    1115                 1120                 1125             


Arg Glu  Val Thr Ser Asp Ser  Gly Ser Ile Val Val  Ser Gly Leu 
    1130                 1135                 1140             


Thr Pro  Gly Val Glu Tyr Val  Tyr Thr Ile Gln Val  Leu Arg Asp 
    1145                 1150                 1155             


Gly Gln  Glu Arg Asp Ala Pro  Ile Val Asn Lys Val  Val Thr Pro 
    1160                 1165                 1170             


Leu Ser  Pro Pro Thr Asn Leu  His Leu Glu Ala Asn  Pro Asp Thr 
    1175                 1180                 1185             


Gly Val  Leu Thr Val Ser Trp  Glu Arg Ser Thr Thr  Pro Asp Ile 
    1190                 1195                 1200             


Thr Gly  Tyr Arg Ile Thr Thr  Thr Pro Thr Asn Gly  Gln Gln Gly 
    1205                 1210                 1215             


Asn Ser  Leu Glu Glu Val Val  His Ala Asp Gln Ser  Ser Cys Thr 
    1220                 1225                 1230             


Phe Asp  Asn Leu Ser Pro Gly  Leu Glu Tyr Asn Val  Ser Val Tyr 
    1235                 1240                 1245             


Thr Val  Lys Asp Asp Lys Glu  Ser Val Pro Ile Ser  Asp Thr Ile 
    1250                 1255                 1260             


Ile Pro  Glu Val Pro Gln Leu  Thr Asp Leu Ser Phe  Val Asp Ile 
    1265                 1270                 1275             


Thr Asp  Ser Ser Ile Gly Leu  Arg Trp Thr Pro Leu  Asn Ser Ser 
    1280                 1285                 1290             


Thr Ile  Ile Gly Tyr Arg Ile  Thr Val Val Ala Ala  Gly Glu Gly 
    1295                 1300                 1305             


Ile Pro  Ile Phe Glu Asp Phe  Val Asp Ser Ser Val  Gly Tyr Tyr 
    1310                 1315                 1320             


Thr Val  Thr Gly Leu Glu Pro  Gly Ile Asp Tyr Asp  Ile Ser Val 
    1325                 1330                 1335             


Ile Thr  Leu Ile Asn Gly Gly  Glu Ser Ala Pro Thr  Thr Leu Thr 
    1340                 1345                 1350             


Gln Gln  Thr Ala Val Pro Pro  Pro Thr Asp Leu Arg  Phe Thr Asn 
    1355                 1360                 1365             


Ile Gly  Pro Asp Thr Met Arg  Val Thr Trp Ala Pro  Pro Pro Ser 
    1370                 1375                 1380             


Ile Asp  Leu Thr Asn Phe Leu  Val Arg Tyr Ser Pro  Val Lys Asn 
    1385                 1390                 1395             


Glu Glu  Asp Val Ala Glu Leu  Ser Ile Ser Pro Ser  Asp Asn Ala 
    1400                 1405                 1410             


Val Val  Leu Thr Asn Leu Leu  Pro Gly Thr Glu Tyr  Val Val Ser 
    1415                 1420                 1425             


Val Ser  Ser Val Tyr Glu Gln  His Glu Ser Thr Pro  Leu Arg Gly 
    1430                 1435                 1440             


Arg Gln  Lys Thr Gly Leu Asp  Ser Pro Thr Gly Ile  Asp Phe Ser 
    1445                 1450                 1455             


Asp Ile  Thr Ala Asn Ser Phe  Thr Val His Trp Ile  Ala Pro Arg 
    1460                 1465                 1470             


Ala Thr  Ile Thr Gly Tyr Arg  Ile Arg His His Pro  Glu His Phe 
    1475                 1480                 1485             


Ser Gly  Arg Pro Arg Glu Asp  Arg Val Pro His Ser  Arg Asn Ser 
    1490                 1495                 1500             


Ile Thr  Leu Thr Asn Leu Thr  Pro Gly Thr Glu Tyr  Val Val Ser 
    1505                 1510                 1515             


Ile Val  Ala Leu Asn Gly Arg  Glu Glu Ser Pro Leu  Leu Ile Gly 
    1520                 1525                 1530             


Gln Gln  Ser Thr Val Ser Asp  Val Pro Arg Asp Leu  Glu Val Val 
    1535                 1540                 1545             


Ala Ala  Thr Pro Thr Ser Leu  Leu Ile Ser Trp Asp  Ala Pro Ala 
    1550                 1555                 1560             


Val Thr  Val Arg Tyr Tyr Arg  Ile Thr Tyr Gly Glu  Thr Gly Gly 
    1565                 1570                 1575             


Asn Ser  Pro Val Gln Glu Phe  Thr Val Pro Gly Ser  Lys Ser Thr 
    1580                 1585                 1590             


Ala Thr  Ile Ser Gly Leu Lys  Pro Gly Val Asp Tyr  Thr Ile Thr 
    1595                 1600                 1605             


Val Tyr  Ala Val Thr Gly Arg  Gly Asp Ser Pro Ala  Ser Ser Lys 
    1610                 1615                 1620             


Pro Ile  Ser Ile Asn Tyr Arg  Thr Glu Ile Asp Lys  Pro Ser Gln 
    1625                 1630                 1635             


Met Gln  Val Thr Asp Val Gln  Asp Asn Ser Ile Ser  Val Lys Trp 
    1640                 1645                 1650             


Leu Pro  Ser Ser Ser Pro Val  Thr Gly Tyr Arg Val  Thr Thr Thr 
    1655                 1660                 1665             


Pro Lys  Asn Gly Pro Gly Pro  Thr Lys Thr Lys Thr  Ala Gly Pro 
    1670                 1675                 1680             


Asp Gln  Thr Glu Met Thr Ile  Glu Gly Leu Gln Pro  Thr Val Glu 
    1685                 1690                 1695             


Tyr Val  Val Ser Val Tyr Ala  Gln Asn Pro Ser Gly  Glu Ser Gln 
    1700                 1705                 1710             


Pro Leu  Val Gln Thr Ala Val  Thr Asn Ile Asp Arg  Pro Lys Gly 
    1715                 1720                 1725             


Leu Ala  Phe Thr Asp Val Asp  Val Asp Ser Ile Lys  Ile Ala Trp 
    1730                 1735                 1740             


Glu Ser  Pro Gln Gly Gln Val  Ser Arg Tyr Arg Val  Thr Tyr Ser 
    1745                 1750                 1755             


Ser Pro  Glu Asp Gly Ile His  Glu Leu Phe Pro Ala  Pro Asp Gly 
    1760                 1765                 1770             


Glu Glu  Asp Thr Ala Glu Leu  Gln Gly Leu Arg Pro  Gly Ser Glu 
    1775                 1780                 1785             


Tyr Thr  Val Ser Val Val Ala  Leu His Asp Asp Met  Glu Ser Gln 
    1790                 1795                 1800             


Pro Leu  Ile Gly Thr Gln Ser  Thr Ala Ile Pro Ala  Pro Thr Asp 
    1805                 1810                 1815             


Leu Lys  Phe Thr Gln Val Thr  Pro Thr Ser Leu Ser  Ala Gln Trp 
    1820                 1825                 1830             


Thr Pro  Pro Asn Val Gln Leu  Thr Gly Tyr Arg Val  Arg Val Thr 
    1835                 1840                 1845             


Pro Lys  Glu Lys Thr Gly Pro  Met Lys Glu Ile Asn  Leu Ala Pro 
    1850                 1855                 1860             


Asp Ser  Ser Ser Val Val Val  Ser Gly Leu Met Val  Ala Thr Lys 
    1865                 1870                 1875             


Tyr Glu  Val Ser Val Tyr Ala  Leu Lys Asp Thr Leu  Thr Ser Arg 
    1880                 1885                 1890             


Pro Ala  Gln Gly Val Val Thr  Thr Leu Glu Asn Val  Ser Pro Pro 
    1895                 1900                 1905             


Arg Arg  Ala Arg Val Thr Asp  Ala Thr Glu Thr Thr  Ile Thr Ile 
    1910                 1915                 1920             


Ser Trp  Arg Thr Lys Thr Glu  Thr Ile Thr Gly Phe  Gln Val Asp 
    1925                 1930                 1935             


Ala Val  Pro Ala Asn Gly Gln  Thr Pro Ile Gln Arg  Thr Ile Lys 
    1940                 1945                 1950             


Pro Asp  Val Arg Ser Tyr Thr  Ile Thr Gly Leu Gln  Pro Gly Thr 
    1955                 1960                 1965             


Asp Tyr  Lys Ile Tyr Leu Tyr  Thr Leu Asn Asp Asn  Ala Arg Ser 
    1970                 1975                 1980             


Ser Pro  Val Val Ile Asp Ala  Ser Thr Ala Ile Asp  Ala Pro Ser 
    1985                 1990                 1995             


Asn Leu  Arg Phe Leu Ala Thr  Thr Pro Asn Ser Leu  Leu Val Ser 
    2000                 2005                 2010             


Trp Gln  Pro Pro Arg Ala Arg  Ile Thr Gly Tyr Ile  Ile Lys Tyr 
    2015                 2020                 2025             


Glu Lys  Pro Gly Ser Pro Pro  Arg Glu Val Val Pro  Arg Pro Arg 
    2030                 2035                 2040             


Pro Gly  Val Thr Glu Ala Thr  Ile Thr Gly Leu Glu  Pro Gly Thr 
    2045                 2050                 2055             


Glu Tyr  Thr Ile Tyr Val Ile  Ala Leu Lys Asn Asn  Gln Lys Ser 
    2060                 2065                 2070             


Glu Pro  Leu Ile Gly Arg Lys  Lys Thr Asp Glu Leu  Pro Gln Leu 
    2075                 2080                 2085             


Val Thr  Leu Pro His Pro Asn  Leu His Gly Pro Glu  Ile Leu Asp 
    2090                 2095                 2100             


Val Pro  Ser Thr Val Gln Lys  Thr Pro Phe Val Thr  His Pro Gly 
    2105                 2110                 2115             


Tyr Asp  Thr Gly Asn Gly Ile  Gln Leu Pro Gly Thr  Ser Gly Gln 
    2120                 2125                 2130             


Gln Pro  Ser Val Gly Gln Gln  Met Ile Phe Glu Glu  His Gly Phe 
    2135                 2140                 2145             


Arg Arg  Thr Thr Pro Pro Thr  Thr Ala Thr Pro Ile  Arg His Arg 
    2150                 2155                 2160             


Pro Arg  Pro Tyr Pro Pro Asn  Val Gly Gln Glu Ala  Leu Ser Gln 
    2165                 2170                 2175             


Thr Thr  Ile Ser Trp Ala Pro  Phe Gln Asp Thr Ser  Glu Tyr Ile 
    2180                 2185                 2190             


Ile Ser  Cys His Pro Val Gly  Thr Asp Glu Glu Pro  Leu Gln Phe 
    2195                 2200                 2205             


Arg Val  Pro Gly Thr Ser Thr  Ser Ala Thr Leu Thr  Gly Leu Thr 
    2210                 2215                 2220             


Arg Gly  Ala Thr Tyr Asn Val  Ile Val Glu Ala Leu  Lys Asp Gln 
    2225                 2230                 2235             


Gln Arg  His Lys Val Arg Glu  Glu Val Val Thr Val  Gly Asn Ser 
    2240                 2245                 2250             


Val Asn  Glu Gly Leu Asn Gln  Pro Thr Asp Asp Ser  Cys Phe Asp 
    2255                 2260                 2265             


Pro Tyr  Thr Val Ser His Tyr  Ala Val Gly Asp Glu  Trp Glu Arg 
    2270                 2275                 2280             


Met Ser  Glu Ser Gly Phe Lys  Leu Leu Cys Gln Cys  Leu Gly Phe 
    2285                 2290                 2295             


Gly Ser  Gly His Phe Arg Cys  Asp Ser Ser Arg Trp  Cys His Asp 
    2300                 2305                 2310             


Asn Gly  Val Asn Tyr Lys Ile  Gly Glu Lys Trp Asp  Arg Gln Gly 
    2315                 2320                 2325             


Glu Asn  Gly Gln Met Met Ser  Cys Thr Cys Leu Gly  Asn Gly Lys 
    2330                 2335                 2340             


Gly Glu  Phe Lys Cys Asp Pro  His Glu Ala Thr Cys  Tyr Asp Asp 
    2345                 2350                 2355             


Gly Lys  Thr Tyr His Val Gly  Glu Gln Trp Gln Lys  Glu Tyr Leu 
    2360                 2365                 2370             


Gly Ala  Ile Cys Ser Cys Thr  Cys Phe Gly Gly Gln  Arg Gly Trp 
    2375                 2380                 2385             


Arg Cys  Asp Asn Cys Arg Arg  Pro Gly Gly Glu Pro  Ser Pro Glu 
    2390                 2395                 2400             


Gly Thr  Thr Gly Gln Ser Tyr  Asn Gln Tyr Ser Gln  Arg Tyr His 
    2405                 2410                 2415             


Gln Arg  Thr Asn Thr Asn Val  Asn Cys Pro Ile Glu  Cys Phe Met 
    2420                 2425                 2430             


Pro Leu  Asp Val Gln Ala Asp  Arg Glu Asp Ser Arg  Glu 
    2435                 2440                 2445     


<210>  5495
<211>  2330
<212>  PRT
<213>  Homo Sapiens

<400>  5495

Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln 
            20                  25                  30          


Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser 
        35                  40                  45              


Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln 
    50                  55                  60                  


Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly 
65                  70                  75                  80  


Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr 
                85                  90                  95      


Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr 
            100                 105                 110         


Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala 
        115                 120                 125             


Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly 
    130                 135                 140                 


Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr 
145                 150                 155                 160 


Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu 
                165                 170                 175     


Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly 
            180                 185                 190         


Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp 
        195                 200                 205             


Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr 
    210                 215                 220                 


Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr 
225                 230                 235                 240 


Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu 
                245                 250                 255     


Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg 
            260                 265                 270         


His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp 
        275                 280                 285             


Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro 
    290                 295                 300                 


Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met 
305                 310                 315                 320 


Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu 
                325                 330                 335     


Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 
            340                 345                 350         


Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly 
        355                 360                 365             


Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 
    370                 375                 380                 


Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe 
385                 390                 395                 400 


Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn 
                405                 410                 415     


Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr 
            420                 425                 430         


Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr 
        435                 440                 445             


Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala 
    450                 455                 460                 


Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 
465                 470                 475                 480 


Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys 
                485                 490                 495     


Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser 
            500                 505                 510         


Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn 
        515                 520                 525             


Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr 
    530                 535                 540                 


Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln 
545                 550                 555                 560 


Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp 
                565                 570                 575     


Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 
            580                 585                 590         


Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser 
        595                 600                 605             


Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn 
    610                 615                 620                 


Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys 
625                 630                 635                 640 


Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu 
                645                 650                 655     


Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys 
            660                 665                 670         


Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly 
        675                 680                 685             


His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr 
    690                 695                 700                 


Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro 
705                 710                 715                 720 


Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe 
                725                 730                 735     


Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val 
            740                 745                 750         


Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu 
        755                 760                 765             


Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg 
    770                 775                 780                 


Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser 
785                 790                 795                 800 


Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp 
                805                 810                 815     


Thr Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser 
            820                 825                 830         


Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser 
        835                 840                 845             


Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser 
    850                 855                 860                 


Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile 
865                 870                 875                 880 


Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln 
                885                 890                 895     


Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp 
            900                 905                 910         


Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr 
        915                 920                 925             


Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val 
    930                 935                 940                 


Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr 
945                 950                 955                 960 


Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys 
                965                 970                 975     


Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln 
            980                 985                 990         


Gln Thr Thr Lys Leu Asp Ala Pro  Thr Asn Leu Gln Phe  Val Asn Glu 
        995                 1000                 1005             


Thr Asp  Ser Thr Val Leu Val  Arg Trp Thr Pro Pro  Arg Ala Gln 
    1010                 1015                 1020             


Ile Thr  Gly Tyr Arg Leu Thr  Val Gly Leu Thr Arg  Arg Gly Gln 
    1025                 1030                 1035             


Pro Arg  Gln Tyr Asn Val Gly  Pro Ser Val Ser Lys  Tyr Pro Leu 
    1040                 1045                 1050             


Arg Asn  Leu Gln Pro Ala Ser  Glu Tyr Thr Val Ser  Leu Val Ala 
    1055                 1060                 1065             


Ile Lys  Gly Asn Gln Glu Ser  Pro Lys Ala Thr Gly  Val Phe Thr 
    1070                 1075                 1080             


Thr Leu  Gln Pro Gly Ser Ser  Ile Pro Pro Tyr Asn  Thr Glu Val 
    1085                 1090                 1095             


Thr Glu  Thr Thr Ile Val Ile  Thr Trp Thr Pro Ala  Pro Arg Ile 
    1100                 1105                 1110             


Gly Phe  Lys Leu Gly Val Arg  Pro Ser Gln Gly Gly  Glu Ala Pro 
    1115                 1120                 1125             


Arg Glu  Val Thr Ser Asp Ser  Gly Ser Ile Val Val  Ser Gly Leu 
    1130                 1135                 1140             


Thr Pro  Gly Val Glu Tyr Val  Tyr Thr Ile Gln Val  Leu Arg Asp 
    1145                 1150                 1155             


Gly Gln  Glu Arg Asp Ala Pro  Ile Val Asn Lys Val  Val Thr Pro 
    1160                 1165                 1170             


Leu Ser  Pro Pro Thr Asn Leu  His Leu Glu Ala Asn  Pro Asp Thr 
    1175                 1180                 1185             


Gly Val  Leu Thr Val Ser Trp  Glu Arg Ser Thr Thr  Pro Asp Ile 
    1190                 1195                 1200             


Thr Gly  Tyr Arg Ile Thr Thr  Thr Pro Thr Asn Gly  Gln Gln Gly 
    1205                 1210                 1215             


Asn Ser  Leu Glu Glu Val Val  His Ala Asp Gln Ser  Ser Cys Thr 
    1220                 1225                 1230             


Phe Asp  Asn Leu Ser Pro Gly  Leu Glu Tyr Asn Val  Ser Val Tyr 
    1235                 1240                 1245             


Thr Val  Lys Asp Asp Lys Glu  Ser Val Pro Ile Ser  Asp Thr Ile 
    1250                 1255                 1260             


Ile Pro  Ala Val Pro Pro Pro  Thr Asp Leu Arg Phe  Thr Asn Ile 
    1265                 1270                 1275             


Gly Pro  Asp Thr Met Arg Val  Thr Trp Ala Pro Pro  Pro Ser Ile 
    1280                 1285                 1290             


Asp Leu  Thr Asn Phe Leu Val  Arg Tyr Ser Pro Val  Lys Asn Glu 
    1295                 1300                 1305             


Glu Asp  Val Ala Glu Leu Ser  Ile Ser Pro Ser Asp  Asn Ala Val 
    1310                 1315                 1320             


Val Leu  Thr Asn Leu Leu Pro  Gly Thr Glu Tyr Val  Val Ser Val 
    1325                 1330                 1335             


Ser Ser  Val Tyr Glu Gln His  Glu Ser Thr Pro Leu  Arg Gly Arg 
    1340                 1345                 1350             


Gln Lys  Thr Gly Leu Asp Ser  Pro Thr Gly Ile Asp  Phe Ser Asp 
    1355                 1360                 1365             


Ile Thr  Ala Asn Ser Phe Thr  Val His Trp Ile Ala  Pro Arg Ala 
    1370                 1375                 1380             


Thr Ile  Thr Gly Tyr Arg Ile  Arg His His Pro Glu  His Phe Ser 
    1385                 1390                 1395             


Gly Arg  Pro Arg Glu Asp Arg  Val Pro His Ser Arg  Asn Ser Ile 
    1400                 1405                 1410             


Thr Leu  Thr Asn Leu Thr Pro  Gly Thr Glu Tyr Val  Val Ser Ile 
    1415                 1420                 1425             


Val Ala  Leu Asn Gly Arg Glu  Glu Ser Pro Leu Leu  Ile Gly Gln 
    1430                 1435                 1440             


Gln Ser  Thr Val Ser Asp Val  Pro Arg Asp Leu Glu  Val Val Ala 
    1445                 1450                 1455             


Ala Thr  Pro Thr Ser Leu Leu  Ile Ser Trp Asp Ala  Pro Ala Val 
    1460                 1465                 1470             


Thr Val  Arg Tyr Tyr Arg Ile  Thr Tyr Gly Glu Thr  Gly Gly Asn 
    1475                 1480                 1485             


Ser Pro  Val Gln Glu Phe Thr  Val Pro Gly Ser Lys  Ser Thr Ala 
    1490                 1495                 1500             


Thr Ile  Ser Gly Leu Lys Pro  Gly Val Asp Tyr Thr  Ile Thr Val 
    1505                 1510                 1515             


Tyr Ala  Val Thr Gly Arg Gly  Asp Ser Pro Ala Ser  Ser Lys Pro 
    1520                 1525                 1530             


Ile Ser  Ile Asn Tyr Arg Thr  Glu Ile Asp Lys Pro  Ser Gln Met 
    1535                 1540                 1545             


Gln Val  Thr Asp Val Gln Asp  Asn Ser Ile Ser Val  Lys Trp Leu 
    1550                 1555                 1560             


Pro Ser  Ser Ser Pro Val Thr  Gly Tyr Arg Val Thr  Thr Thr Pro 
    1565                 1570                 1575             


Lys Asn  Gly Pro Gly Pro Thr  Lys Thr Lys Thr Ala  Gly Pro Asp 
    1580                 1585                 1590             


Gln Thr  Glu Met Thr Ile Glu  Gly Leu Gln Pro Thr  Val Glu Tyr 
    1595                 1600                 1605             


Val Val  Ser Val Tyr Ala Gln  Asn Pro Ser Gly Glu  Ser Gln Pro 
    1610                 1615                 1620             


Leu Val  Gln Thr Ala Val Thr  Asn Ile Asp Arg Pro  Lys Gly Leu 
    1625                 1630                 1635             


Ala Phe  Thr Asp Val Asp Val  Asp Ser Ile Lys Ile  Ala Trp Glu 
    1640                 1645                 1650             


Ser Pro  Gln Gly Gln Val Ser  Arg Tyr Arg Val Thr  Tyr Ser Ser 
    1655                 1660                 1665             


Pro Glu  Asp Gly Ile His Glu  Leu Phe Pro Ala Pro  Asp Gly Glu 
    1670                 1675                 1680             


Glu Asp  Thr Ala Glu Leu Gln  Gly Leu Arg Pro Gly  Ser Glu Tyr 
    1685                 1690                 1695             


Thr Val  Ser Val Val Ala Leu  His Asp Asp Met Glu  Ser Gln Pro 
    1700                 1705                 1710             


Leu Ile  Gly Thr Gln Ser Thr  Ala Ile Pro Ala Pro  Thr Asp Leu 
    1715                 1720                 1725             


Lys Phe  Thr Gln Val Thr Pro  Thr Ser Leu Ser Ala  Gln Trp Thr 
    1730                 1735                 1740             


Pro Pro  Asn Val Gln Leu Thr  Gly Tyr Arg Val Arg  Val Thr Pro 
    1745                 1750                 1755             


Lys Glu  Lys Thr Gly Pro Met  Lys Glu Ile Asn Leu  Ala Pro Asp 
    1760                 1765                 1770             


Ser Ser  Ser Val Val Val Ser  Gly Leu Met Val Ala  Thr Lys Tyr 
    1775                 1780                 1785             


Glu Val  Ser Val Tyr Ala Leu  Lys Asp Thr Leu Thr  Ser Arg Pro 
    1790                 1795                 1800             


Ala Gln  Gly Val Val Thr Thr  Leu Glu Asn Val Ser  Pro Pro Arg 
    1805                 1810                 1815             


Arg Ala  Arg Val Thr Asp Ala  Thr Glu Thr Thr Ile  Thr Ile Ser 
    1820                 1825                 1830             


Trp Arg  Thr Lys Thr Glu Thr  Ile Thr Gly Phe Gln  Val Asp Ala 
    1835                 1840                 1845             


Val Pro  Ala Asn Gly Gln Thr  Pro Ile Gln Arg Thr  Ile Lys Pro 
    1850                 1855                 1860             


Asp Val  Arg Ser Tyr Thr Ile  Thr Gly Leu Gln Pro  Gly Thr Asp 
    1865                 1870                 1875             


Tyr Lys  Ile Tyr Leu Tyr Thr  Leu Asn Asp Asn Ala  Arg Ser Ser 
    1880                 1885                 1890             


Pro Val  Val Ile Asp Ala Ser  Thr Ala Ile Asp Ala  Pro Ser Asn 
    1895                 1900                 1905             


Leu Arg  Phe Leu Ala Thr Thr  Pro Asn Ser Leu Leu  Val Ser Trp 
    1910                 1915                 1920             


Gln Pro  Pro Arg Ala Arg Ile  Thr Gly Tyr Ile Ile  Lys Tyr Glu 
    1925                 1930                 1935             


Lys Pro  Gly Ser Pro Pro Arg  Glu Val Val Pro Arg  Pro Arg Pro 
    1940                 1945                 1950             


Gly Val  Thr Glu Ala Thr Ile  Thr Gly Leu Glu Pro  Gly Thr Glu 
    1955                 1960                 1965             


Tyr Thr  Ile Tyr Val Ile Ala  Leu Lys Asn Asn Gln  Lys Ser Glu 
    1970                 1975                 1980             


Pro Leu  Ile Gly Arg Lys Lys  Thr Val Gln Lys Thr  Pro Phe Val 
    1985                 1990                 1995             


Thr His  Pro Gly Tyr Asp Thr  Gly Asn Gly Ile Gln  Leu Pro Gly 
    2000                 2005                 2010             


Thr Ser  Gly Gln Gln Pro Ser  Val Gly Gln Gln Met  Ile Phe Glu 
    2015                 2020                 2025             


Glu His  Gly Phe Arg Arg Thr  Thr Pro Pro Thr Thr  Ala Thr Pro 
    2030                 2035                 2040             


Ile Arg  His Arg Pro Arg Pro  Tyr Pro Pro Asn Val  Gly Gln Glu 
    2045                 2050                 2055             


Ala Leu  Ser Gln Thr Thr Ile  Ser Trp Ala Pro Phe  Gln Asp Thr 
    2060                 2065                 2070             


Ser Glu  Tyr Ile Ile Ser Cys  His Pro Val Gly Thr  Asp Glu Glu 
    2075                 2080                 2085             


Pro Leu  Gln Phe Arg Val Pro  Gly Thr Ser Thr Ser  Ala Thr Leu 
    2090                 2095                 2100             


Thr Gly  Leu Thr Arg Gly Ala  Thr Tyr Asn Val Ile  Val Glu Ala 
    2105                 2110                 2115             


Leu Lys  Asp Gln Gln Arg His  Lys Val Arg Glu Glu  Val Val Thr 
    2120                 2125                 2130             


Val Gly  Asn Ser Val Asn Glu  Gly Leu Asn Gln Pro  Thr Asp Asp 
    2135                 2140                 2145             


Ser Cys  Phe Asp Pro Tyr Thr  Val Ser His Tyr Ala  Val Gly Asp 
    2150                 2155                 2160             


Glu Trp  Glu Arg Met Ser Glu  Ser Gly Phe Lys Leu  Leu Cys Gln 
    2165                 2170                 2175             


Cys Leu  Gly Phe Gly Ser Gly  His Phe Arg Cys Asp  Ser Ser Arg 
    2180                 2185                 2190             


Trp Cys  His Asp Asn Gly Val  Asn Tyr Lys Ile Gly  Glu Lys Trp 
    2195                 2200                 2205             


Asp Arg  Gln Gly Glu Asn Gly  Gln Met Met Ser Cys  Thr Cys Leu 
    2210                 2215                 2220             


Gly Asn  Gly Lys Gly Glu Phe  Lys Cys Asp Pro His  Glu Ala Thr 
    2225                 2230                 2235             


Cys Tyr  Asp Asp Gly Lys Thr  Tyr His Val Gly Glu  Gln Trp Gln 
    2240                 2245                 2250             


Lys Glu  Tyr Leu Gly Ala Ile  Cys Ser Cys Thr Cys  Phe Gly Gly 
    2255                 2260                 2265             


Gln Arg  Gly Trp Arg Cys Asp  Asn Cys Arg Arg Pro  Gly Gly Glu 
    2270                 2275                 2280             


Pro Ser  Pro Glu Gly Thr Thr  Gly Gln Ser Tyr Asn  Gln Tyr Ser 
    2285                 2290                 2295             


Gln Arg  Tyr His Gln Arg Thr  Asn Thr Asn Val Asn  Cys Pro Ile 
    2300                 2305                 2310             


Glu Cys  Phe Met Pro Leu Asp  Val Gln Ala Asp Arg  Glu Asp Ser 
    2315                 2320                 2325             


Arg Glu  
    2330 


<210>  5496
<211>  2240
<212>  PRT
<213>  Homo Sapiens

<400>  5496

Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln 
            20                  25                  30          


Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser 
        35                  40                  45              


Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln 
    50                  55                  60                  


Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly 
65                  70                  75                  80  


Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr 
                85                  90                  95      


Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr 
            100                 105                 110         


Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala 
        115                 120                 125             


Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly 
    130                 135                 140                 


Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr 
145                 150                 155                 160 


Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu 
                165                 170                 175     


Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly 
            180                 185                 190         


Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp 
        195                 200                 205             


Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr 
    210                 215                 220                 


Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr 
225                 230                 235                 240 


Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu 
                245                 250                 255     


Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg 
            260                 265                 270         


His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp 
        275                 280                 285             


Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro 
    290                 295                 300                 


Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met 
305                 310                 315                 320 


Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu 
                325                 330                 335     


Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 
            340                 345                 350         


Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly 
        355                 360                 365             


Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 
    370                 375                 380                 


Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe 
385                 390                 395                 400 


Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn 
                405                 410                 415     


Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr 
            420                 425                 430         


Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr 
        435                 440                 445             


Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala 
    450                 455                 460                 


Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 
465                 470                 475                 480 


Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys 
                485                 490                 495     


Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser 
            500                 505                 510         


Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn 
        515                 520                 525             


Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr 
    530                 535                 540                 


Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln 
545                 550                 555                 560 


Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp 
                565                 570                 575     


Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 
            580                 585                 590         


Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser 
        595                 600                 605             


Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn 
    610                 615                 620                 


Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys 
625                 630                 635                 640 


Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu 
                645                 650                 655     


Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys 
            660                 665                 670         


Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly 
        675                 680                 685             


His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr 
    690                 695                 700                 


Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro 
705                 710                 715                 720 


Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe 
                725                 730                 735     


Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val 
            740                 745                 750         


Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu 
        755                 760                 765             


Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg 
    770                 775                 780                 


Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser 
785                 790                 795                 800 


Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp 
                805                 810                 815     


Thr Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser 
            820                 825                 830         


Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser 
        835                 840                 845             


Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser 
    850                 855                 860                 


Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile 
865                 870                 875                 880 


Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln 
                885                 890                 895     


Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp 
            900                 905                 910         


Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr 
        915                 920                 925             


Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val 
    930                 935                 940                 


Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr 
945                 950                 955                 960 


Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys 
                965                 970                 975     


Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln 
            980                 985                 990         


Gln Thr Thr Lys Leu Asp Ala Pro  Thr Asn Leu Gln Phe  Val Asn Glu 
        995                 1000                 1005             


Thr Asp  Ser Thr Val Leu Val  Arg Trp Thr Pro Pro  Arg Ala Gln 
    1010                 1015                 1020             


Ile Thr  Gly Tyr Arg Leu Thr  Val Gly Leu Thr Arg  Arg Gly Gln 
    1025                 1030                 1035             


Pro Arg  Gln Tyr Asn Val Gly  Pro Ser Val Ser Lys  Tyr Pro Leu 
    1040                 1045                 1050             


Arg Asn  Leu Gln Pro Ala Ser  Glu Tyr Thr Val Ser  Leu Val Ala 
    1055                 1060                 1065             


Ile Lys  Gly Asn Gln Glu Ser  Pro Lys Ala Thr Gly  Val Phe Thr 
    1070                 1075                 1080             


Thr Leu  Gln Pro Gly Ser Ser  Ile Pro Pro Tyr Asn  Thr Glu Val 
    1085                 1090                 1095             


Thr Glu  Thr Thr Ile Val Ile  Thr Trp Thr Pro Ala  Pro Arg Ile 
    1100                 1105                 1110             


Gly Phe  Lys Leu Gly Val Arg  Pro Ser Gln Gly Gly  Glu Ala Pro 
    1115                 1120                 1125             


Arg Glu  Val Thr Ser Asp Ser  Gly Ser Ile Val Val  Ser Gly Leu 
    1130                 1135                 1140             


Thr Pro  Gly Val Glu Tyr Val  Tyr Thr Ile Gln Val  Leu Arg Asp 
    1145                 1150                 1155             


Gly Gln  Glu Arg Asp Ala Pro  Ile Val Asn Lys Val  Val Thr Pro 
    1160                 1165                 1170             


Leu Ser  Pro Pro Thr Asn Leu  His Leu Glu Ala Asn  Pro Asp Thr 
    1175                 1180                 1185             


Gly Val  Leu Thr Val Ser Trp  Glu Arg Ser Thr Thr  Pro Asp Ile 
    1190                 1195                 1200             


Thr Gly  Tyr Arg Ile Thr Thr  Thr Pro Thr Asn Gly  Gln Gln Gly 
    1205                 1210                 1215             


Asn Ser  Leu Glu Glu Val Val  His Ala Asp Gln Ser  Ser Cys Thr 
    1220                 1225                 1230             


Phe Asp  Asn Leu Ser Pro Gly  Leu Glu Tyr Asn Val  Ser Val Tyr 
    1235                 1240                 1245             


Thr Val  Lys Asp Asp Lys Glu  Ser Val Pro Ile Ser  Asp Thr Ile 
    1250                 1255                 1260             


Ile Pro  Ala Val Pro Pro Pro  Thr Asp Leu Arg Phe  Thr Asn Ile 
    1265                 1270                 1275             


Gly Pro  Asp Thr Met Arg Val  Thr Trp Ala Pro Pro  Pro Ser Ile 
    1280                 1285                 1290             


Asp Leu  Thr Asn Phe Leu Val  Arg Tyr Ser Pro Val  Lys Asn Glu 
    1295                 1300                 1305             


Glu Asp  Val Ala Glu Leu Ser  Ile Ser Pro Ser Asp  Asn Ala Val 
    1310                 1315                 1320             


Val Leu  Thr Asn Leu Leu Pro  Gly Thr Glu Tyr Val  Val Ser Val 
    1325                 1330                 1335             


Ser Ser  Val Tyr Glu Gln His  Glu Ser Thr Pro Leu  Arg Gly Arg 
    1340                 1345                 1350             


Gln Lys  Thr Gly Leu Asp Ser  Pro Thr Gly Ile Asp  Phe Ser Asp 
    1355                 1360                 1365             


Ile Thr  Ala Asn Ser Phe Thr  Val His Trp Ile Ala  Pro Arg Ala 
    1370                 1375                 1380             


Thr Ile  Thr Gly Tyr Arg Ile  Arg His His Pro Glu  His Phe Ser 
    1385                 1390                 1395             


Gly Arg  Pro Arg Glu Asp Arg  Val Pro His Ser Arg  Asn Ser Ile 
    1400                 1405                 1410             


Thr Leu  Thr Asn Leu Thr Pro  Gly Thr Glu Tyr Val  Val Ser Ile 
    1415                 1420                 1425             


Val Ala  Leu Asn Gly Arg Glu  Glu Ser Pro Leu Leu  Ile Gly Gln 
    1430                 1435                 1440             


Gln Ser  Thr Val Ser Asp Val  Pro Arg Asp Leu Glu  Val Val Ala 
    1445                 1450                 1455             


Ala Thr  Pro Thr Ser Leu Leu  Ile Ser Trp Asp Ala  Pro Ala Val 
    1460                 1465                 1470             


Thr Val  Arg Tyr Tyr Arg Ile  Thr Tyr Gly Glu Thr  Gly Gly Asn 
    1475                 1480                 1485             


Ser Pro  Val Gln Glu Phe Thr  Val Pro Gly Ser Lys  Ser Thr Ala 
    1490                 1495                 1500             


Thr Ile  Ser Gly Leu Lys Pro  Gly Val Asp Tyr Thr  Ile Thr Val 
    1505                 1510                 1515             


Tyr Ala  Val Thr Gly Arg Gly  Asp Ser Pro Ala Ser  Ser Lys Pro 
    1520                 1525                 1530             


Ile Ser  Ile Asn Tyr Arg Thr  Glu Ile Asp Lys Pro  Ser Gln Met 
    1535                 1540                 1545             


Gln Val  Thr Asp Val Gln Asp  Asn Ser Ile Ser Val  Lys Trp Leu 
    1550                 1555                 1560             


Pro Ser  Ser Ser Pro Val Thr  Gly Tyr Arg Val Thr  Thr Thr Pro 
    1565                 1570                 1575             


Lys Asn  Gly Pro Gly Pro Thr  Lys Thr Lys Thr Ala  Gly Pro Asp 
    1580                 1585                 1590             


Gln Thr  Glu Met Thr Ile Glu  Gly Leu Gln Pro Thr  Val Glu Tyr 
    1595                 1600                 1605             


Val Val  Ser Val Tyr Ala Gln  Asn Pro Ser Gly Glu  Ser Gln Pro 
    1610                 1615                 1620             


Leu Val  Gln Thr Ala Val Thr  Thr Ile Pro Ala Pro  Thr Asp Leu 
    1625                 1630                 1635             


Lys Phe  Thr Gln Val Thr Pro  Thr Ser Leu Ser Ala  Gln Trp Thr 
    1640                 1645                 1650             


Pro Pro  Asn Val Gln Leu Thr  Gly Tyr Arg Val Arg  Val Thr Pro 
    1655                 1660                 1665             


Lys Glu  Lys Thr Gly Pro Met  Lys Glu Ile Asn Leu  Ala Pro Asp 
    1670                 1675                 1680             


Ser Ser  Ser Val Val Val Ser  Gly Leu Met Val Ala  Thr Lys Tyr 
    1685                 1690                 1695             


Glu Val  Ser Val Tyr Ala Leu  Lys Asp Thr Leu Thr  Ser Arg Pro 
    1700                 1705                 1710             


Ala Gln  Gly Val Val Thr Thr  Leu Glu Asn Val Ser  Pro Pro Arg 
    1715                 1720                 1725             


Arg Ala  Arg Val Thr Asp Ala  Thr Glu Thr Thr Ile  Thr Ile Ser 
    1730                 1735                 1740             


Trp Arg  Thr Lys Thr Glu Thr  Ile Thr Gly Phe Gln  Val Asp Ala 
    1745                 1750                 1755             


Val Pro  Ala Asn Gly Gln Thr  Pro Ile Gln Arg Thr  Ile Lys Pro 
    1760                 1765                 1770             


Asp Val  Arg Ser Tyr Thr Ile  Thr Gly Leu Gln Pro  Gly Thr Asp 
    1775                 1780                 1785             


Tyr Lys  Ile Tyr Leu Tyr Thr  Leu Asn Asp Asn Ala  Arg Ser Ser 
    1790                 1795                 1800             


Pro Val  Val Ile Asp Ala Ser  Thr Ala Ile Asp Ala  Pro Ser Asn 
    1805                 1810                 1815             


Leu Arg  Phe Leu Ala Thr Thr  Pro Asn Ser Leu Leu  Val Ser Trp 
    1820                 1825                 1830             


Gln Pro  Pro Arg Ala Arg Ile  Thr Gly Tyr Ile Ile  Lys Tyr Glu 
    1835                 1840                 1845             


Lys Pro  Gly Ser Pro Pro Arg  Glu Val Val Pro Arg  Pro Arg Pro 
    1850                 1855                 1860             


Gly Val  Thr Glu Ala Thr Ile  Thr Gly Leu Glu Pro  Gly Thr Glu 
    1865                 1870                 1875             


Tyr Thr  Ile Tyr Val Ile Ala  Leu Lys Asn Asn Gln  Lys Ser Glu 
    1880                 1885                 1890             


Pro Leu  Ile Gly Arg Lys Lys  Thr Val Gln Lys Thr  Pro Phe Val 
    1895                 1900                 1905             


Thr His  Pro Gly Tyr Asp Thr  Gly Asn Gly Ile Gln  Leu Pro Gly 
    1910                 1915                 1920             


Thr Ser  Gly Gln Gln Pro Ser  Val Gly Gln Gln Met  Ile Phe Glu 
    1925                 1930                 1935             


Glu His  Gly Phe Arg Arg Thr  Thr Pro Pro Thr Thr  Ala Thr Pro 
    1940                 1945                 1950             


Ile Arg  His Arg Pro Arg Pro  Tyr Pro Pro Asn Val  Gly Gln Glu 
    1955                 1960                 1965             


Ala Leu  Ser Gln Thr Thr Ile  Ser Trp Ala Pro Phe  Gln Asp Thr 
    1970                 1975                 1980             


Ser Glu  Tyr Ile Ile Ser Cys  His Pro Val Gly Thr  Asp Glu Glu 
    1985                 1990                 1995             


Pro Leu  Gln Phe Arg Val Pro  Gly Thr Ser Thr Ser  Ala Thr Leu 
    2000                 2005                 2010             


Thr Gly  Leu Thr Arg Gly Ala  Thr Tyr Asn Val Ile  Val Glu Ala 
    2015                 2020                 2025             


Leu Lys  Asp Gln Gln Arg His  Lys Val Arg Glu Glu  Val Val Thr 
    2030                 2035                 2040             


Val Gly  Asn Ser Val Asn Glu  Gly Leu Asn Gln Pro  Thr Asp Asp 
    2045                 2050                 2055             


Ser Cys  Phe Asp Pro Tyr Thr  Val Ser His Tyr Ala  Val Gly Asp 
    2060                 2065                 2070             


Glu Trp  Glu Arg Met Ser Glu  Ser Gly Phe Lys Leu  Leu Cys Gln 
    2075                 2080                 2085             


Cys Leu  Gly Phe Gly Ser Gly  His Phe Arg Cys Asp  Ser Ser Arg 
    2090                 2095                 2100             


Trp Cys  His Asp Asn Gly Val  Asn Tyr Lys Ile Gly  Glu Lys Trp 
    2105                 2110                 2115             


Asp Arg  Gln Gly Glu Asn Gly  Gln Met Met Ser Cys  Thr Cys Leu 
    2120                 2125                 2130             


Gly Asn  Gly Lys Gly Glu Phe  Lys Cys Asp Pro His  Glu Ala Thr 
    2135                 2140                 2145             


Cys Tyr  Asp Asp Gly Lys Thr  Tyr His Val Gly Glu  Gln Trp Gln 
    2150                 2155                 2160             


Lys Glu  Tyr Leu Gly Ala Ile  Cys Ser Cys Thr Cys  Phe Gly Gly 
    2165                 2170                 2175             


Gln Arg  Gly Trp Arg Cys Asp  Asn Cys Arg Arg Pro  Gly Gly Glu 
    2180                 2185                 2190             


Pro Ser  Pro Glu Gly Thr Thr  Gly Gln Ser Tyr Asn  Gln Tyr Ser 
    2195                 2200                 2205             


Gln Arg  Tyr His Gln Arg Thr  Asn Thr Asn Val Asn  Cys Pro Ile 
    2210                 2215                 2220             


Glu Cys  Phe Met Pro Leu Asp  Val Gln Ala Asp Arg  Glu Asp Ser 
    2225                 2230                 2235             


Arg Glu  
    2240 


<210>  5497
<211>  657
<212>  PRT
<213>  Homo Sapiens

<400>  5497

Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln 
            20                  25                  30          


Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser 
        35                  40                  45              


Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln 
    50                  55                  60                  


Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly 
65                  70                  75                  80  


Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr 
                85                  90                  95      


Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr 
            100                 105                 110         


Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala 
        115                 120                 125             


Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly 
    130                 135                 140                 


Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr 
145                 150                 155                 160 


Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu 
                165                 170                 175     


Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly 
            180                 185                 190         


Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp 
        195                 200                 205             


Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr 
    210                 215                 220                 


Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr 
225                 230                 235                 240 


Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu 
                245                 250                 255     


Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg 
            260                 265                 270         


His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp 
        275                 280                 285             


Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro 
    290                 295                 300                 


Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met 
305                 310                 315                 320 


Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu 
                325                 330                 335     


Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 
            340                 345                 350         


Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly 
        355                 360                 365             


Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 
    370                 375                 380                 


Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe 
385                 390                 395                 400 


Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn 
                405                 410                 415     


Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr 
            420                 425                 430         


Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr 
        435                 440                 445             


Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala 
    450                 455                 460                 


Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 
465                 470                 475                 480 


Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys 
                485                 490                 495     


Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser 
            500                 505                 510         


Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn 
        515                 520                 525             


Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr 
    530                 535                 540                 


Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln 
545                 550                 555                 560 


Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp 
                565                 570                 575     


Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 
            580                 585                 590         


Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser 
        595                 600                 605             


Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn 
    610                 615                 620                 


Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys 
625                 630                 635                 640 


Tyr Ile Leu Arg Trp Arg Pro Val Ser Ile Pro Pro Arg Asn Leu Gly 
                645                 650                 655     


Tyr 
    


<210>  5498
<211>  2267
<212>  PRT
<213>  Homo Sapiens

<400>  5498

Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln 
            20                  25                  30          


Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser 
        35                  40                  45              


Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln 
    50                  55                  60                  


Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly 
65                  70                  75                  80  


Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr 
                85                  90                  95      


Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr 
            100                 105                 110         


Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala 
        115                 120                 125             


Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly 
    130                 135                 140                 


Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr 
145                 150                 155                 160 


Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu 
                165                 170                 175     


Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly 
            180                 185                 190         


Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp 
        195                 200                 205             


Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr 
    210                 215                 220                 


Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr 
225                 230                 235                 240 


Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu 
                245                 250                 255     


Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg 
            260                 265                 270         


His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp 
        275                 280                 285             


Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro 
    290                 295                 300                 


Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met 
305                 310                 315                 320 


Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu 
                325                 330                 335     


Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 
            340                 345                 350         


Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly 
        355                 360                 365             


Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 
    370                 375                 380                 


Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe 
385                 390                 395                 400 


Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn 
                405                 410                 415     


Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr 
            420                 425                 430         


Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr 
        435                 440                 445             


Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala 
    450                 455                 460                 


Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 
465                 470                 475                 480 


Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys 
                485                 490                 495     


Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser 
            500                 505                 510         


Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn 
        515                 520                 525             


Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr 
    530                 535                 540                 


Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln 
545                 550                 555                 560 


Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp 
                565                 570                 575     


Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 
            580                 585                 590         


Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser 
        595                 600                 605             


Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn 
    610                 615                 620                 


Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys 
625                 630                 635                 640 


Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu 
                645                 650                 655     


Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys 
            660                 665                 670         


Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly 
        675                 680                 685             


His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr 
    690                 695                 700                 


Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro 
705                 710                 715                 720 


Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe 
                725                 730                 735     


Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val 
            740                 745                 750         


Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu 
        755                 760                 765             


Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg 
    770                 775                 780                 


Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser 
785                 790                 795                 800 


Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp 
                805                 810                 815     


Thr Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser 
            820                 825                 830         


Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser 
        835                 840                 845             


Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser 
    850                 855                 860                 


Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile 
865                 870                 875                 880 


Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln 
                885                 890                 895     


Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp 
            900                 905                 910         


Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr 
        915                 920                 925             


Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val 
    930                 935                 940                 


Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr 
945                 950                 955                 960 


Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys 
                965                 970                 975     


Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln 
            980                 985                 990         


Gln Thr Thr Lys Leu Asp Ala Pro  Thr Asn Leu Gln Phe  Val Asn Glu 
        995                 1000                 1005             


Thr Asp  Ser Thr Val Leu Val  Arg Trp Thr Pro Pro  Arg Ala Gln 
    1010                 1015                 1020             


Ile Thr  Gly Tyr Arg Leu Thr  Val Gly Leu Thr Arg  Arg Gly Gln 
    1025                 1030                 1035             


Pro Arg  Gln Tyr Asn Val Gly  Pro Ser Val Ser Lys  Tyr Pro Leu 
    1040                 1045                 1050             


Arg Asn  Leu Gln Pro Ala Ser  Glu Tyr Thr Val Ser  Leu Val Ala 
    1055                 1060                 1065             


Ile Lys  Gly Asn Gln Glu Ser  Pro Lys Ala Thr Gly  Val Phe Thr 
    1070                 1075                 1080             


Thr Leu  Gln Pro Gly Ser Ser  Ile Pro Pro Tyr Asn  Thr Glu Val 
    1085                 1090                 1095             


Thr Glu  Thr Thr Ile Val Ile  Thr Trp Thr Pro Ala  Pro Arg Ile 
    1100                 1105                 1110             


Gly Phe  Lys Leu Gly Val Arg  Pro Ser Gln Gly Gly  Glu Ala Pro 
    1115                 1120                 1125             


Arg Glu  Val Thr Ser Asp Ser  Gly Ser Ile Val Val  Ser Gly Leu 
    1130                 1135                 1140             


Thr Pro  Gly Val Glu Tyr Val  Tyr Thr Ile Gln Val  Leu Arg Asp 
    1145                 1150                 1155             


Gly Gln  Glu Arg Asp Ala Pro  Ile Val Asn Lys Val  Val Thr Pro 
    1160                 1165                 1170             


Leu Ser  Pro Pro Thr Asn Leu  His Leu Glu Ala Asn  Pro Asp Thr 
    1175                 1180                 1185             


Gly Val  Leu Thr Val Ser Trp  Glu Arg Ser Thr Thr  Pro Asp Ile 
    1190                 1195                 1200             


Thr Gly  Tyr Arg Ile Thr Thr  Thr Pro Thr Asn Gly  Gln Gln Gly 
    1205                 1210                 1215             


Asn Ser  Leu Glu Glu Val Val  His Ala Asp Gln Ser  Ser Cys Thr 
    1220                 1225                 1230             


Phe Asp  Asn Leu Ser Pro Gly  Leu Glu Tyr Asn Val  Ser Val Tyr 
    1235                 1240                 1245             


Thr Val  Lys Asp Asp Lys Glu  Ser Val Pro Ile Ser  Asp Thr Ile 
    1250                 1255                 1260             


Ile Pro  Glu Val Pro Gln Leu  Thr Asp Leu Ser Phe  Val Asp Ile 
    1265                 1270                 1275             


Thr Asp  Ser Ser Ile Gly Leu  Arg Trp Thr Pro Leu  Asn Ser Ser 
    1280                 1285                 1290             


Thr Ile  Ile Gly Tyr Arg Ile  Thr Val Val Ala Ala  Gly Glu Gly 
    1295                 1300                 1305             


Ile Pro  Ile Phe Glu Asp Phe  Val Asp Ser Ser Val  Gly Tyr Tyr 
    1310                 1315                 1320             


Thr Val  Thr Gly Leu Glu Pro  Gly Ile Asp Tyr Asp  Ile Ser Val 
    1325                 1330                 1335             


Ile Thr  Leu Ile Asn Gly Gly  Glu Ser Ala Pro Thr  Thr Leu Thr 
    1340                 1345                 1350             


Gln Gln  Thr Ala Val Pro Pro  Pro Thr Asp Leu Arg  Phe Thr Asn 
    1355                 1360                 1365             


Ile Gly  Pro Asp Thr Met Arg  Val Thr Trp Ala Pro  Pro Pro Ser 
    1370                 1375                 1380             


Ile Asp  Leu Thr Asn Phe Leu  Val Arg Tyr Ser Pro  Val Lys Asn 
    1385                 1390                 1395             


Glu Glu  Asp Val Ala Glu Leu  Ser Ile Ser Pro Ser  Asp Asn Ala 
    1400                 1405                 1410             


Val Val  Leu Thr Asn Leu Leu  Pro Gly Thr Glu Tyr  Val Val Ser 
    1415                 1420                 1425             


Val Ser  Ser Val Tyr Glu Gln  His Glu Ser Thr Pro  Leu Arg Gly 
    1430                 1435                 1440             


Arg Gln  Lys Thr Gly Leu Asp  Ser Pro Thr Gly Ile  Asp Phe Ser 
    1445                 1450                 1455             


Asp Ile  Thr Ala Asn Ser Phe  Thr Val His Trp Ile  Ala Pro Arg 
    1460                 1465                 1470             


Ala Thr  Ile Thr Gly Tyr Arg  Ile Arg His His Pro  Glu His Phe 
    1475                 1480                 1485             


Ser Gly  Arg Pro Arg Glu Asp  Arg Val Pro His Ser  Arg Asn Ser 
    1490                 1495                 1500             


Ile Thr  Leu Thr Asn Leu Thr  Pro Gly Thr Glu Tyr  Val Val Ser 
    1505                 1510                 1515             


Ile Val  Ala Leu Asn Gly Arg  Glu Glu Ser Pro Leu  Leu Ile Gly 
    1520                 1525                 1530             


Gln Gln  Ser Thr Val Ser Asp  Val Pro Arg Asp Leu  Glu Val Val 
    1535                 1540                 1545             


Ala Ala  Thr Pro Thr Ser Leu  Leu Ile Ser Trp Asp  Ala Pro Ala 
    1550                 1555                 1560             


Val Thr  Val Arg Tyr Tyr Arg  Ile Thr Tyr Gly Glu  Thr Gly Gly 
    1565                 1570                 1575             


Asn Ser  Pro Val Gln Glu Phe  Thr Val Pro Gly Ser  Lys Ser Thr 
    1580                 1585                 1590             


Ala Thr  Ile Ser Gly Leu Lys  Pro Gly Val Asp Tyr  Thr Ile Thr 
    1595                 1600                 1605             


Val Tyr  Ala Val Thr Gly Arg  Gly Asp Ser Pro Ala  Ser Ser Lys 
    1610                 1615                 1620             


Pro Ile  Ser Ile Asn Tyr Arg  Thr Glu Ile Asp Lys  Pro Ser Gln 
    1625                 1630                 1635             


Met Gln  Val Thr Asp Val Gln  Asp Asn Ser Ile Ser  Val Lys Trp 
    1640                 1645                 1650             


Leu Pro  Ser Ser Ser Pro Val  Thr Gly Tyr Arg Val  Thr Thr Thr 
    1655                 1660                 1665             


Pro Lys  Asn Gly Pro Gly Pro  Thr Lys Thr Lys Thr  Ala Gly Pro 
    1670                 1675                 1680             


Asp Gln  Thr Glu Met Thr Ile  Glu Gly Leu Gln Pro  Thr Val Glu 
    1685                 1690                 1695             


Tyr Val  Val Ser Val Tyr Ala  Gln Asn Pro Ser Gly  Glu Ser Gln 
    1700                 1705                 1710             


Pro Leu  Val Gln Thr Ala Val  Thr Thr Ile Pro Ala  Pro Thr Asp 
    1715                 1720                 1725             


Leu Lys  Phe Thr Gln Val Thr  Pro Thr Ser Leu Ser  Ala Gln Trp 
    1730                 1735                 1740             


Thr Pro  Pro Asn Val Gln Leu  Thr Gly Tyr Arg Val  Arg Val Thr 
    1745                 1750                 1755             


Pro Lys  Glu Lys Thr Gly Pro  Met Lys Glu Ile Asn  Leu Ala Pro 
    1760                 1765                 1770             


Asp Ser  Ser Ser Val Val Val  Ser Gly Leu Met Val  Ala Thr Lys 
    1775                 1780                 1785             


Tyr Glu  Val Ser Val Tyr Ala  Leu Lys Asp Thr Leu  Thr Ser Arg 
    1790                 1795                 1800             


Pro Ala  Gln Gly Val Val Thr  Thr Leu Glu Asn Val  Ser Pro Pro 
    1805                 1810                 1815             


Arg Arg  Ala Arg Val Thr Asp  Ala Thr Glu Thr Thr  Ile Thr Ile 
    1820                 1825                 1830             


Ser Trp  Arg Thr Lys Thr Glu  Thr Ile Thr Gly Phe  Gln Val Asp 
    1835                 1840                 1845             


Ala Val  Pro Ala Asn Gly Gln  Thr Pro Ile Gln Arg  Thr Ile Lys 
    1850                 1855                 1860             


Pro Asp  Val Arg Ser Tyr Thr  Ile Thr Gly Leu Gln  Pro Gly Thr 
    1865                 1870                 1875             


Asp Tyr  Lys Ile Tyr Leu Tyr  Thr Leu Asn Asp Asn  Ala Arg Ser 
    1880                 1885                 1890             


Ser Pro  Val Val Ile Asp Ala  Ser Thr Ala Ile Asp  Ala Pro Ser 
    1895                 1900                 1905             


Asn Leu  Arg Phe Leu Ala Thr  Thr Pro Asn Ser Leu  Leu Val Ser 
    1910                 1915                 1920             


Trp Gln  Pro Pro Arg Ala Arg  Ile Thr Gly Tyr Ile  Ile Lys Tyr 
    1925                 1930                 1935             


Glu Lys  Pro Gly Ser Pro Pro  Arg Glu Val Val Pro  Arg Pro Arg 
    1940                 1945                 1950             


Pro Gly  Val Thr Glu Ala Thr  Ile Thr Gly Leu Glu  Pro Gly Thr 
    1955                 1960                 1965             


Glu Tyr  Thr Ile Tyr Val Ile  Ala Leu Lys Asn Asn  Gln Lys Ser 
    1970                 1975                 1980             


Glu Pro  Leu Ile Gly Arg Lys  Lys Thr Gly Gln Glu  Ala Leu Ser 
    1985                 1990                 1995             


Gln Thr  Thr Ile Ser Trp Ala  Pro Phe Gln Asp Thr  Ser Glu Tyr 
    2000                 2005                 2010             


Ile Ile  Ser Cys His Pro Val  Gly Thr Asp Glu Glu  Pro Leu Gln 
    2015                 2020                 2025             


Phe Arg  Val Pro Gly Thr Ser  Thr Ser Ala Thr Leu  Thr Gly Leu 
    2030                 2035                 2040             


Thr Arg  Gly Ala Thr Tyr Asn  Val Ile Val Glu Ala  Leu Lys Asp 
    2045                 2050                 2055             


Gln Gln  Arg His Lys Val Arg  Glu Glu Val Val Thr  Val Gly Asn 
    2060                 2065                 2070             


Ser Val  Asn Glu Gly Leu Asn  Gln Pro Thr Asp Asp  Ser Cys Phe 
    2075                 2080                 2085             


Asp Pro  Tyr Thr Val Ser His  Tyr Ala Val Gly Asp  Glu Trp Glu 
    2090                 2095                 2100             


Arg Met  Ser Glu Ser Gly Phe  Lys Leu Leu Cys Gln  Cys Leu Gly 
    2105                 2110                 2115             


Phe Gly  Ser Gly His Phe Arg  Cys Asp Ser Ser Arg  Trp Cys His 
    2120                 2125                 2130             


Asp Asn  Gly Val Asn Tyr Lys  Ile Gly Glu Lys Trp  Asp Arg Gln 
    2135                 2140                 2145             


Gly Glu  Asn Gly Gln Met Met  Ser Cys Thr Cys Leu  Gly Asn Gly 
    2150                 2155                 2160             


Lys Gly  Glu Phe Lys Cys Asp  Pro His Glu Ala Thr  Cys Tyr Asp 
    2165                 2170                 2175             


Asp Gly  Lys Thr Tyr His Val  Gly Glu Gln Trp Gln  Lys Glu Tyr 
    2180                 2185                 2190             


Leu Gly  Ala Ile Cys Ser Cys  Thr Cys Phe Gly Gly  Gln Arg Gly 
    2195                 2200                 2205             


Trp Arg  Cys Asp Asn Cys Arg  Arg Pro Gly Gly Glu  Pro Ser Pro 
    2210                 2215                 2220             


Glu Gly  Thr Thr Gly Gln Ser  Tyr Asn Gln Tyr Ser  Gln Arg Tyr 
    2225                 2230                 2235             


His Gln  Arg Thr Asn Thr Asn  Val Asn Cys Pro Ile  Glu Cys Phe 
    2240                 2245                 2250             


Met Pro  Leu Asp Val Gln Ala  Asp Arg Glu Asp Ser  Arg Glu 
    2255                 2260                 2265         


<210>  5499
<211>  2265
<212>  PRT
<213>  Homo Sapiens

<400>  5499

Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln 
            20                  25                  30          


Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser 
        35                  40                  45              


Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln 
    50                  55                  60                  


Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly 
65                  70                  75                  80  


Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr 
                85                  90                  95      


Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr 
            100                 105                 110         


Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala 
        115                 120                 125             


Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly 
    130                 135                 140                 


Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr 
145                 150                 155                 160 


Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu 
                165                 170                 175     


Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly 
            180                 185                 190         


Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp 
        195                 200                 205             


Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr 
    210                 215                 220                 


Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr 
225                 230                 235                 240 


Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu 
                245                 250                 255     


Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg 
            260                 265                 270         


His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp 
        275                 280                 285             


Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro 
    290                 295                 300                 


Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met 
305                 310                 315                 320 


Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu 
                325                 330                 335     


Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 
            340                 345                 350         


Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly 
        355                 360                 365             


Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 
    370                 375                 380                 


Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe 
385                 390                 395                 400 


Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn 
                405                 410                 415     


Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr 
            420                 425                 430         


Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr 
        435                 440                 445             


Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala 
    450                 455                 460                 


Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 
465                 470                 475                 480 


Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys 
                485                 490                 495     


Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser 
            500                 505                 510         


Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn 
        515                 520                 525             


Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr 
    530                 535                 540                 


Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln 
545                 550                 555                 560 


Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp 
                565                 570                 575     


Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 
            580                 585                 590         


Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser 
        595                 600                 605             


Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn 
    610                 615                 620                 


Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys 
625                 630                 635                 640 


Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu 
                645                 650                 655     


Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys 
            660                 665                 670         


Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly 
        675                 680                 685             


His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr 
    690                 695                 700                 


Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro 
705                 710                 715                 720 


Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe 
                725                 730                 735     


Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val 
            740                 745                 750         


Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu 
        755                 760                 765             


Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg 
    770                 775                 780                 


Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser 
785                 790                 795                 800 


Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp 
                805                 810                 815     


Thr Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser 
            820                 825                 830         


Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser 
        835                 840                 845             


Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser 
    850                 855                 860                 


Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile 
865                 870                 875                 880 


Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln 
                885                 890                 895     


Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp 
            900                 905                 910         


Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr 
        915                 920                 925             


Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val 
    930                 935                 940                 


Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr 
945                 950                 955                 960 


Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys 
                965                 970                 975     


Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln 
            980                 985                 990         


Gln Thr Thr Lys Leu Asp Ala Pro  Thr Asn Leu Gln Phe  Val Asn Glu 
        995                 1000                 1005             


Thr Asp  Ser Thr Val Leu Val  Arg Trp Thr Pro Pro  Arg Ala Gln 
    1010                 1015                 1020             


Ile Thr  Gly Tyr Arg Leu Thr  Val Gly Leu Thr Arg  Arg Gly Gln 
    1025                 1030                 1035             


Pro Arg  Gln Tyr Asn Val Gly  Pro Ser Val Ser Lys  Tyr Pro Leu 
    1040                 1045                 1050             


Arg Asn  Leu Gln Pro Ala Ser  Glu Tyr Thr Val Ser  Leu Val Ala 
    1055                 1060                 1065             


Ile Lys  Gly Asn Gln Glu Ser  Pro Lys Ala Thr Gly  Val Phe Thr 
    1070                 1075                 1080             


Thr Leu  Gln Pro Gly Ser Ser  Ile Pro Pro Tyr Asn  Thr Glu Val 
    1085                 1090                 1095             


Thr Glu  Thr Thr Ile Val Ile  Thr Trp Thr Pro Ala  Pro Arg Ile 
    1100                 1105                 1110             


Gly Phe  Lys Leu Gly Val Arg  Pro Ser Gln Gly Gly  Glu Ala Pro 
    1115                 1120                 1125             


Arg Glu  Val Thr Ser Asp Ser  Gly Ser Ile Val Val  Ser Gly Leu 
    1130                 1135                 1140             


Thr Pro  Gly Val Glu Tyr Val  Tyr Thr Ile Gln Val  Leu Arg Asp 
    1145                 1150                 1155             


Gly Gln  Glu Arg Asp Ala Pro  Ile Val Asn Lys Val  Val Thr Pro 
    1160                 1165                 1170             


Leu Ser  Pro Pro Thr Asn Leu  His Leu Glu Ala Asn  Pro Asp Thr 
    1175                 1180                 1185             


Gly Val  Leu Thr Val Ser Trp  Glu Arg Ser Thr Thr  Pro Asp Ile 
    1190                 1195                 1200             


Thr Gly  Tyr Arg Ile Thr Thr  Thr Pro Thr Asn Gly  Gln Gln Gly 
    1205                 1210                 1215             


Asn Ser  Leu Glu Glu Val Val  His Ala Asp Gln Ser  Ser Cys Thr 
    1220                 1225                 1230             


Phe Asp  Asn Leu Ser Pro Gly  Leu Glu Tyr Asn Val  Ser Val Tyr 
    1235                 1240                 1245             


Thr Val  Lys Asp Asp Lys Glu  Ser Val Pro Ile Ser  Asp Thr Ile 
    1250                 1255                 1260             


Ile Pro  Ala Val Pro Pro Pro  Thr Asp Leu Arg Phe  Thr Asn Ile 
    1265                 1270                 1275             


Gly Pro  Asp Thr Met Arg Val  Thr Trp Ala Pro Pro  Pro Ser Ile 
    1280                 1285                 1290             


Asp Leu  Thr Asn Phe Leu Val  Arg Tyr Ser Pro Val  Lys Asn Glu 
    1295                 1300                 1305             


Glu Asp  Val Ala Glu Leu Ser  Ile Ser Pro Ser Asp  Asn Ala Val 
    1310                 1315                 1320             


Val Leu  Thr Asn Leu Leu Pro  Gly Thr Glu Tyr Val  Val Ser Val 
    1325                 1330                 1335             


Ser Ser  Val Tyr Glu Gln His  Glu Ser Thr Pro Leu  Arg Gly Arg 
    1340                 1345                 1350             


Gln Lys  Thr Gly Leu Asp Ser  Pro Thr Gly Ile Asp  Phe Ser Asp 
    1355                 1360                 1365             


Ile Thr  Ala Asn Ser Phe Thr  Val His Trp Ile Ala  Pro Arg Ala 
    1370                 1375                 1380             


Thr Ile  Thr Gly Tyr Arg Ile  Arg His His Pro Glu  His Phe Ser 
    1385                 1390                 1395             


Gly Arg  Pro Arg Glu Asp Arg  Val Pro His Ser Arg  Asn Ser Ile 
    1400                 1405                 1410             


Thr Leu  Thr Asn Leu Thr Pro  Gly Thr Glu Tyr Val  Val Ser Ile 
    1415                 1420                 1425             


Val Ala  Leu Asn Gly Arg Glu  Glu Ser Pro Leu Leu  Ile Gly Gln 
    1430                 1435                 1440             


Gln Ser  Thr Val Ser Asp Val  Pro Arg Asp Leu Glu  Val Val Ala 
    1445                 1450                 1455             


Ala Thr  Pro Thr Ser Leu Leu  Ile Ser Trp Asp Ala  Pro Ala Val 
    1460                 1465                 1470             


Thr Val  Arg Tyr Tyr Arg Ile  Thr Tyr Gly Glu Thr  Gly Gly Asn 
    1475                 1480                 1485             


Ser Pro  Val Gln Glu Phe Thr  Val Pro Gly Ser Lys  Ser Thr Ala 
    1490                 1495                 1500             


Thr Ile  Ser Gly Leu Lys Pro  Gly Val Asp Tyr Thr  Ile Thr Val 
    1505                 1510                 1515             


Tyr Ala  Val Thr Gly Arg Gly  Asp Ser Pro Ala Ser  Ser Lys Pro 
    1520                 1525                 1530             


Ile Ser  Ile Asn Tyr Arg Thr  Glu Ile Asp Lys Pro  Ser Gln Met 
    1535                 1540                 1545             


Gln Val  Thr Asp Val Gln Asp  Asn Ser Ile Ser Val  Lys Trp Leu 
    1550                 1555                 1560             


Pro Ser  Ser Ser Pro Val Thr  Gly Tyr Arg Val Thr  Thr Thr Pro 
    1565                 1570                 1575             


Lys Asn  Gly Pro Gly Pro Thr  Lys Thr Lys Thr Ala  Gly Pro Asp 
    1580                 1585                 1590             


Gln Thr  Glu Met Thr Ile Glu  Gly Leu Gln Pro Thr  Val Glu Tyr 
    1595                 1600                 1605             


Val Val  Ser Val Tyr Ala Gln  Asn Pro Ser Gly Glu  Ser Gln Pro 
    1610                 1615                 1620             


Leu Val  Gln Thr Ala Val Thr  Thr Ile Pro Ala Pro  Thr Asp Leu 
    1625                 1630                 1635             


Lys Phe  Thr Gln Val Thr Pro  Thr Ser Leu Ser Ala  Gln Trp Thr 
    1640                 1645                 1650             


Pro Pro  Asn Val Gln Leu Thr  Gly Tyr Arg Val Arg  Val Thr Pro 
    1655                 1660                 1665             


Lys Glu  Lys Thr Gly Pro Met  Lys Glu Ile Asn Leu  Ala Pro Asp 
    1670                 1675                 1680             


Ser Ser  Ser Val Val Val Ser  Gly Leu Met Val Ala  Thr Lys Tyr 
    1685                 1690                 1695             


Glu Val  Ser Val Tyr Ala Leu  Lys Asp Thr Leu Thr  Ser Arg Pro 
    1700                 1705                 1710             


Ala Gln  Gly Val Val Thr Thr  Leu Glu Asn Val Ser  Pro Pro Arg 
    1715                 1720                 1725             


Arg Ala  Arg Val Thr Asp Ala  Thr Glu Thr Thr Ile  Thr Ile Ser 
    1730                 1735                 1740             


Trp Arg  Thr Lys Thr Glu Thr  Ile Thr Gly Phe Gln  Val Asp Ala 
    1745                 1750                 1755             


Val Pro  Ala Asn Gly Gln Thr  Pro Ile Gln Arg Thr  Ile Lys Pro 
    1760                 1765                 1770             


Asp Val  Arg Ser Tyr Thr Ile  Thr Gly Leu Gln Pro  Gly Thr Asp 
    1775                 1780                 1785             


Tyr Lys  Ile Tyr Leu Tyr Thr  Leu Asn Asp Asn Ala  Arg Ser Ser 
    1790                 1795                 1800             


Pro Val  Val Ile Asp Ala Ser  Thr Ala Ile Asp Ala  Pro Ser Asn 
    1805                 1810                 1815             


Leu Arg  Phe Leu Ala Thr Thr  Pro Asn Ser Leu Leu  Val Ser Trp 
    1820                 1825                 1830             


Gln Pro  Pro Arg Ala Arg Ile  Thr Gly Tyr Ile Ile  Lys Tyr Glu 
    1835                 1840                 1845             


Lys Pro  Gly Ser Pro Pro Arg  Glu Val Val Pro Arg  Pro Arg Pro 
    1850                 1855                 1860             


Gly Val  Thr Glu Ala Thr Ile  Thr Gly Leu Glu Pro  Gly Thr Glu 
    1865                 1870                 1875             


Tyr Thr  Ile Tyr Val Ile Ala  Leu Lys Asn Asn Gln  Lys Ser Glu 
    1880                 1885                 1890             


Pro Leu  Ile Gly Arg Lys Lys  Thr Asp Glu Leu Pro  Gln Leu Val 
    1895                 1900                 1905             


Thr Leu  Pro His Pro Asn Leu  His Gly Pro Glu Ile  Leu Asp Val 
    1910                 1915                 1920             


Pro Ser  Thr Val Gln Lys Thr  Pro Phe Val Thr His  Pro Gly Tyr 
    1925                 1930                 1935             


Asp Thr  Gly Asn Gly Ile Gln  Leu Pro Gly Thr Ser  Gly Gln Gln 
    1940                 1945                 1950             


Pro Ser  Val Gly Gln Gln Met  Ile Phe Glu Glu His  Gly Phe Arg 
    1955                 1960                 1965             


Arg Thr  Thr Pro Pro Thr Thr  Ala Thr Pro Ile Arg  His Arg Pro 
    1970                 1975                 1980             


Arg Pro  Tyr Pro Pro Asn Val  Gly Gln Glu Ala Leu  Ser Gln Thr 
    1985                 1990                 1995             


Thr Ile  Ser Trp Ala Pro Phe  Gln Asp Thr Ser Glu  Tyr Ile Ile 
    2000                 2005                 2010             


Ser Cys  His Pro Val Gly Thr  Asp Glu Glu Pro Leu  Gln Phe Arg 
    2015                 2020                 2025             


Val Pro  Gly Thr Ser Thr Ser  Ala Thr Leu Thr Gly  Leu Thr Arg 
    2030                 2035                 2040             


Gly Ala  Thr Tyr Asn Val Ile  Val Glu Ala Leu Lys  Asp Gln Gln 
    2045                 2050                 2055             


Arg His  Lys Val Arg Glu Glu  Val Val Thr Val Gly  Asn Ser Val 
    2060                 2065                 2070             


Asn Glu  Gly Leu Asn Gln Pro  Thr Asp Asp Ser Cys  Phe Asp Pro 
    2075                 2080                 2085             


Tyr Thr  Val Ser His Tyr Ala  Val Gly Asp Glu Trp  Glu Arg Met 
    2090                 2095                 2100             


Ser Glu  Ser Gly Phe Lys Leu  Leu Cys Gln Cys Leu  Gly Phe Gly 
    2105                 2110                 2115             


Ser Gly  His Phe Arg Cys Asp  Ser Ser Arg Trp Cys  His Asp Asn 
    2120                 2125                 2130             


Gly Val  Asn Tyr Lys Ile Gly  Glu Lys Trp Asp Arg  Gln Gly Glu 
    2135                 2140                 2145             


Asn Gly  Gln Met Met Ser Cys  Thr Cys Leu Gly Asn  Gly Lys Gly 
    2150                 2155                 2160             


Glu Phe  Lys Cys Asp Pro His  Glu Ala Thr Cys Tyr  Asp Asp Gly 
    2165                 2170                 2175             


Lys Thr  Tyr His Val Gly Glu  Gln Trp Gln Lys Glu  Tyr Leu Gly 
    2180                 2185                 2190             


Ala Ile  Cys Ser Cys Thr Cys  Phe Gly Gly Gln Arg  Gly Trp Arg 
    2195                 2200                 2205             


Cys Asp  Asn Cys Arg Arg Pro  Gly Gly Glu Pro Ser  Pro Glu Gly 
    2210                 2215                 2220             


Thr Thr  Gly Gln Ser Tyr Asn  Gln Tyr Ser Gln Arg  Tyr His Gln 
    2225                 2230                 2235             


Arg Thr  Asn Thr Asn Val Asn  Cys Pro Ile Glu Cys  Phe Met Pro 
    2240                 2245                 2250             


Leu Asp  Val Gln Ala Asp Arg  Glu Asp Ser Arg Glu  
    2255                 2260                 2265 


<210>  5500
<211>  241
<212>  PRT
<213>  Homo Sapiens

<400>  5500

Tyr Leu Tyr Thr Leu Asn Asp Asn Ala Arg Ser Ser Pro Val Val Ile 
1               5                   10                  15      


Asp Ala Ser Thr Ala Ile Asp Ala Pro Ser Asn Leu Arg Phe Leu Ala 
            20                  25                  30          


Thr Thr Pro Asn Ser Leu Leu Val Ser Trp Gln Pro Pro Arg Ala Arg 
        35                  40                  45              


Ile Thr Gly Tyr Ile Ile Lys Tyr Glu Lys Pro Gly Ser Pro Pro Arg 
    50                  55                  60                  


Glu Val Val Pro Arg Pro Arg Pro Gly Val Thr Glu Ala Thr Ile Thr 
65                  70                  75                  80  


Gly Leu Glu Pro Gly Thr Glu Tyr Thr Ile Tyr Val Ile Ala Leu Lys 
                85                  90                  95      


Asn Asn Gln Lys Ser Glu Pro Leu Ile Gly Arg Lys Lys Thr Val Gln 
            100                 105                 110         


Lys Thr Pro Phe Val Thr His Pro Gly Tyr Asp Thr Gly Asn Gly Ile 
        115                 120                 125             


Gln Leu Pro Gly Thr Ser Gly Gln Gln Pro Ser Val Gly Gln Gln Met 
    130                 135                 140                 


Ile Phe Glu Glu His Gly Phe Arg Arg Thr Thr Pro Pro Thr Thr Ala 
145                 150                 155                 160 


Thr Pro Ile Arg His Arg Pro Arg Pro Tyr Pro Pro Asn Val Gly Glu 
                165                 170                 175     


Glu Ile Gln Ile Gly His Ile Pro Arg Glu Asp Val Asp Tyr His Leu 
            180                 185                 190         


Tyr Pro His Gly Pro Gly Leu Asn Pro Asn Ala Ser Thr Gly Gln Glu 
        195                 200                 205             


Ala Leu Ser Gln Thr Thr Ile Ser Trp Ala Pro Phe Gln Asp Thr Ser 
    210                 215                 220                 


Glu Tyr Ile Ile Ser Cys His Pro Val Gly Thr Asp Glu Glu Pro Leu 
225                 230                 235                 240 


Gln 
    


<210>  5501
<211>  1894
<212>  PRT
<213>  Homo Sapiens

<400>  5501

Met Ala Pro Glu Ala Gly Ala Thr Leu Arg Ala Pro Arg Arg Leu Ser 
1               5                   10                  15      


Trp Ala Ala Leu Leu Leu Leu Ala Ala Leu Leu Pro Val Ala Ser Ser 
            20                  25                  30          


Ala Ala Ala Ser Val Asp His Pro Leu Lys Pro Arg His Val Lys Leu 
        35                  40                  45              


Leu Ser Thr Lys Met Gly Leu Lys Val Thr Trp Asp Pro Pro Lys Asp 
    50                  55                  60                  


Ala Thr Ser Arg Pro Val Glu His Tyr Asn Ile Ala Tyr Gly Lys Ser 
65                  70                  75                  80  


Leu Lys Ser Leu Lys Tyr Ile Lys Val Asn Ala Glu Thr Tyr Ser Phe 
                85                  90                  95      


Leu Ile Glu Asp Val Glu Pro Gly Val Val Tyr Phe Val Leu Leu Thr 
            100                 105                 110         


Ala Glu Asn His Ser Gly Val Ser Arg Pro Val Tyr Arg Ala Glu Ser 
        115                 120                 125             


Pro Pro Gly Gly Glu Trp Ile Glu Ile Asp Gly Phe Pro Ile Lys Gly 
    130                 135                 140                 


Pro Gly Pro Phe Asn Glu Thr Val Thr Glu Lys Glu Val Pro Asn Lys 
145                 150                 155                 160 


Pro Leu Arg Val Arg Val Arg Ser Ser Asp Asp Arg Leu Ser Val Ala 
                165                 170                 175     


Trp Lys Ala Pro Arg Leu Ser Gly Ala Lys Ser Pro Arg Arg Ser Arg 
            180                 185                 190         


Gly Phe Leu Leu Gly Tyr Gly Glu Ser Gly Arg Lys Met Asn Tyr Val 
        195                 200                 205             


Pro Leu Thr Arg Asp Glu Arg Thr His Glu Ile Lys Lys Leu Ala Ser 
    210                 215                 220                 


Glu Ser Val Tyr Val Val Ser Leu Gln Ser Met Asn Ser Gln Gly Arg 
225                 230                 235                 240 


Ser Gln Pro Val Tyr Arg Ala Ala Leu Thr Lys Arg Lys Ile Ser Glu 
                245                 250                 255     


Glu Asp Glu Leu Asp Val Pro Asp Asp Ile Ser Val Arg Val Met Ser 
            260                 265                 270         


Ser Gln Ser Val Leu Val Ser Trp Val Asp Pro Val Leu Glu Lys Gln 
        275                 280                 285             


Lys Lys Val Val Ala Ser Arg Gln Tyr Thr Val Arg Tyr Arg Glu Lys 
    290                 295                 300                 


Gly Glu Leu Ala Arg Trp Asp Tyr Lys Gln Ile Ala Asn Arg Arg Val 
305                 310                 315                 320 


Leu Ile Glu Asn Leu Ile Pro Asp Thr Val Tyr Glu Phe Ala Val Arg 
                325                 330                 335     


Ile Ser Gln Gly Glu Arg Asp Gly Lys Trp Ser Thr Ser Val Phe Gln 
            340                 345                 350         


Arg Thr Pro Glu Ser Ala Pro Thr Thr Ala Pro Glu Asn Leu Asn Val 
        355                 360                 365             


Trp Pro Val Asn Gly Lys Pro Thr Val Val Ala Ala Ser Trp Asp Ala 
    370                 375                 380                 


Leu Pro Glu Thr Glu Gly Lys Val Lys Glu Tyr Ile Leu Ser Tyr Ala 
385                 390                 395                 400 


Pro Ala Leu Lys Pro Phe Gly Ala Lys Ser Leu Thr Tyr Pro Gly Asp 
                405                 410                 415     


Thr Thr Ser Ala Leu Val Asp Gly Leu Gln Pro Gly Glu Arg Tyr Leu 
            420                 425                 430         


Phe Lys Ile Arg Ala Thr Asn Arg Arg Gly Leu Gly Pro His Ser Lys 
        435                 440                 445             


Ala Phe Ile Val Ala Met Pro Thr Thr Ser Lys Ala Asp Val Glu Gln 
    450                 455                 460                 


Asn Thr Glu Asp Asn Gly Lys Pro Glu Lys Pro Glu Pro Ser Ser Pro 
465                 470                 475                 480 


Ser Pro Arg Ala Pro Ala Ser Ser Gln His Pro Ser Val Pro Ala Ser 
                485                 490                 495     


Pro Gln Gly Arg Asn Ala Lys Asp Leu Leu Leu Asp Leu Lys Asn Lys 
            500                 505                 510         


Ile Leu Ala Asn Gly Gly Ala Pro Arg Lys Pro Gln Leu Arg Ala Lys 
        515                 520                 525             


Lys Ala Glu Glu Leu Asp Leu Gln Ser Thr Glu Ile Thr Gly Glu Glu 
    530                 535                 540                 


Glu Leu Gly Ser Arg Glu Asp Ser Pro Met Ser Pro Ser Asp Thr Gln 
545                 550                 555                 560 


Asp Gln Lys Arg Thr Leu Arg Pro Pro Ser Arg His Gly His Ser Val 
                565                 570                 575     


Val Ala Pro Gly Arg Thr Ala Val Arg Ala Arg Met Pro Ala Leu Pro 
            580                 585                 590         


Arg Arg Glu Gly Val Asp Lys Pro Gly Phe Ser Leu Ala Thr Gln Pro 
        595                 600                 605             


Arg Pro Gly Ala Pro Pro Ser Ala Ser Ala Ser Pro Ala His His Ala 
    610                 615                 620                 


Ser Thr Gln Gly Thr Ser His Arg Pro Ser Leu Pro Ala Ser Leu Asn 
625                 630                 635                 640 


Asp Asn Asp Leu Val Asp Ser Asp Glu Asp Glu Arg Ala Val Gly Ser 
                645                 650                 655     


Leu His Pro Lys Gly Ala Phe Ala Gln Pro Arg Pro Ala Leu Ser Pro 
            660                 665                 670         


Ser Arg Gln Ser Pro Ser Ser Val Leu Arg Asp Arg Ser Ser Val His 
        675                 680                 685             


Pro Gly Ala Lys Pro Ala Ser Pro Ala Arg Arg Thr Pro His Ser Gly 
    690                 695                 700                 


Ala Ala Glu Glu Asp Ser Ser Ala Ser Ala Pro Pro Ser Arg Leu Ser 
705                 710                 715                 720 


Pro Pro His Gly Gly Ser Ser Arg Leu Leu Pro Thr Gln Pro His Leu 
                725                 730                 735     


Ser Ser Pro Leu Ser Lys Gly Gly Lys Asp Gly Glu Asp Ala Pro Ala 
            740                 745                 750         


Thr Asn Ser Asn Ala Pro Ser Arg Ser Thr Met Ser Ser Ser Val Ser 
        755                 760                 765             


Ser His Leu Ser Ser Arg Thr Gln Val Ser Glu Gly Ala Glu Ala Ser 
    770                 775                 780                 


Asp Gly Glu Ser His Gly Asp Gly Asp Arg Glu Asp Gly Gly Arg Gln 
785                 790                 795                 800 


Ala Glu Ala Thr Ala Gln Thr Leu Arg Ala Arg Pro Ala Ser Gly His 
                805                 810                 815     


Phe His Leu Leu Arg His Lys Pro Phe Ala Ala Asn Gly Arg Ser Pro 
            820                 825                 830         


Ser Arg Phe Ser Ile Gly Arg Gly Pro Arg Leu Gln Pro Ser Ser Ser 
        835                 840                 845             


Pro Gln Ser Thr Val Pro Ser Arg Ala His Pro Arg Val Pro Ser His 
    850                 855                 860                 


Ser Asp Ser His Pro Lys Leu Ser Ser Gly Ile His Gly Asp Glu Glu 
865                 870                 875                 880 


Asp Glu Lys Pro Leu Pro Ala Thr Val Val Asn Asp His Val Pro Ser 
                885                 890                 895     


Ser Ser Arg Gln Pro Ile Ser Arg Gly Trp Glu Asp Leu Arg Arg Ser 
            900                 905                 910         


Pro Gln Arg Gly Ala Ser Leu His Arg Lys Glu Pro Ile Pro Glu Asn 
        915                 920                 925             


Pro Lys Ser Thr Gly Ala Asp Thr His Pro Gln Gly Lys Tyr Ser Ser 
    930                 935                 940                 


Leu Ala Ser Lys Ala Gln Asp Val Gln Gln Ser Thr Asp Ala Asp Thr 
945                 950                 955                 960 


Glu Gly His Ser Pro Lys Ala Gln Pro Gly Ser Thr Asp Arg His Ala 
                965                 970                 975     


Ser Pro Ala Arg Pro Pro Ala Ala Arg Ser Gln Gln His Pro Ser Val 
            980                 985                 990         


Pro Arg Arg Met Thr Pro Gly Arg  Ala Pro Gln Gln Gln  Pro Pro Pro 
        995                 1000                 1005             


Pro Val  Ala Thr Ser Gln His  His Pro Gly Pro Gln  Ser Arg Asp 
    1010                 1015                 1020             


Ala Gly  Arg Ser Pro Ser Gln  Pro Arg Leu Ser Leu  Thr Gln Ala 
    1025                 1030                 1035             


Gly Arg  Pro Arg Pro Thr Ser  Gln Gly Arg Ser His  Ser Ser Ser 
    1040                 1045                 1050             


Asp Pro  Tyr Thr Ala Ser Ser  Arg Gly Met Leu Pro  Thr Ala Leu 
    1055                 1060                 1065             


Gln Asn  Gln Asp Glu Asp Ala  Gln Gly Ser Tyr Asp  Asp Asp Ser 
    1070                 1075                 1080             


Thr Glu  Val Glu Ala Gln Asp  Val Arg Ala Pro Ala  His Ala Ala 
    1085                 1090                 1095             


Arg Ala  Lys Glu Ala Ala Ala  Ser Leu Pro Lys His  Gln Gln Val 
    1100                 1105                 1110             


Glu Ser  Pro Thr Gly Ala Gly  Ala Gly Gly Asp His  Arg Ser Gln 
    1115                 1120                 1125             


Arg Gly  His Ala Ala Ser Pro  Ala Arg Pro Ser Arg  Pro Gly Gly 
    1130                 1135                 1140             


Pro Gln  Ser Arg Ala Arg Val  Pro Ser Arg Ala Ala  Pro Gly Lys 
    1145                 1150                 1155             


Ser Glu  Pro Pro Ser Lys Arg  Pro Leu Ser Ser Lys  Ser Gln Gln 
    1160                 1165                 1170             


Ser Val  Ser Ala Glu Asp Asp  Glu Glu Glu Asp Ala  Gly Phe Phe 
    1175                 1180                 1185             


Lys Gly  Gly Lys Glu Asp Leu  Leu Ser Ser Ser Val  Pro Lys Trp 
    1190                 1195                 1200             


Pro Ser  Ser Ser Thr Pro Arg  Gly Gly Lys Asp Ala  Asp Gly Ser 
    1205                 1210                 1215             


Leu Ala  Lys Glu Glu Arg Glu  Pro Ala Ile Ala Leu  Ala Pro Arg 
    1220                 1225                 1230             


Gly Gly  Ser Leu Ala Pro Val  Lys Arg Pro Leu Pro  Pro Pro Pro 
    1235                 1240                 1245             


Gly Ser  Ser Pro Arg Ala Ser  His Val Pro Ser Arg  Leu Pro Pro 
    1250                 1255                 1260             


Arg Ser  Ala Ala Thr Val Ser  Pro Val Ala Gly Thr  His Pro Trp 
    1265                 1270                 1275             


Pro Gln  Tyr Thr Thr Arg Ala  Pro Pro Gly His Phe  Ser Thr Thr 
    1280                 1285                 1290             


Pro Met  Leu Ser Leu Arg Gln  Arg Met Met His Ala  Arg Phe Arg 
    1295                 1300                 1305             


Asn Pro  Leu Ser Arg Gln Pro  Ala Arg Pro Ser Tyr  Arg Gln Gly 
    1310                 1315                 1320             


Tyr Asn  Gly Arg Pro Asn Val  Glu Gly Lys Val Leu  Pro Gly Ser 
    1325                 1330                 1335             


Asn Gly  Lys Pro Asn Gly Gln  Arg Ile Ile Asn Gly  Pro Gln Gly 
    1340                 1345                 1350             


Thr Lys  Trp Val Val Asp Leu  Asp Arg Gly Leu Val  Leu Asn Ala 
    1355                 1360                 1365             


Glu Gly  Arg Tyr Leu Gln Asp  Ser His Gly Asn Pro  Leu Arg Ile 
    1370                 1375                 1380             


Lys Leu  Gly Gly Asp Gly Arg  Thr Ile Val Asp Leu  Glu Gly Thr 
    1385                 1390                 1395             


Pro Val  Val Ser Pro Asp Gly  Leu Pro Leu Phe Gly  Gln Gly Arg 
    1400                 1405                 1410             


His Gly  Thr Pro Leu Ala Asn  Ala Gln Asp Lys Pro  Ile Leu Ser 
    1415                 1420                 1425             


Leu Gly  Gly Lys Pro Leu Val  Gly Leu Glu Val Ile  Lys Lys Thr 
    1430                 1435                 1440             


Thr His  Pro Pro Thr Thr Thr  Met Gln Pro Thr Thr  Thr Thr Thr 
    1445                 1450                 1455             


Pro Leu  Pro Thr Thr Thr Thr  Pro Arg Pro Thr Thr  Ala Thr Thr 
    1460                 1465                 1470             


Arg Arg  Thr Thr Thr Thr Arg  Arg Thr Thr Thr Arg  Arg Pro Thr 
    1475                 1480                 1485             


Thr Thr  Val Arg Thr Thr Thr  Arg Thr Thr Thr Thr  Thr Thr Pro 
    1490                 1495                 1500             


Thr Pro  Thr Thr Pro Ile Pro  Thr Cys Pro Pro Gly  Thr Leu Glu 
    1505                 1510                 1515             


Arg His  Asp Asp Asp Gly Asn  Leu Ile Met Ser Ser  Asn Gly Ile 
    1520                 1525                 1530             


Pro Glu  Cys Tyr Ala Glu Glu  Asp Glu Phe Ser Gly  Leu Glu Thr 
    1535                 1540                 1545             


Asp Thr  Ala Val Pro Thr Glu  Glu Ala Tyr Val Ile  Tyr Asp Glu 
    1550                 1555                 1560             


Asp Tyr  Glu Phe Glu Thr Ser  Arg Pro Pro Thr Thr  Thr Glu Pro 
    1565                 1570                 1575             


Ser Thr  Thr Ala Thr Thr Pro  Arg Val Ile Pro Glu  Glu Gly Ala 
    1580                 1585                 1590             


Ile Ser  Ser Phe Pro Glu Glu  Glu Phe Asp Leu Ala  Gly Arg Lys 
    1595                 1600                 1605             


Arg Phe  Val Ala Pro Tyr Val  Thr Tyr Leu Asn Lys  Asp Pro Ser 
    1610                 1615                 1620             


Ala Pro  Cys Ser Leu Thr Asp  Ala Leu Asp His Phe  Gln Val Asp 
    1625                 1630                 1635             


Ser Leu  Asp Glu Ile Ile Pro  Asn Asp Leu Lys Lys  Ser Asp Leu 
    1640                 1645                 1650             


Pro Pro  Gln His Ala Pro Arg  Asn Ile Thr Val Val  Ala Val Glu 
    1655                 1660                 1665             


Gly Cys  His Ser Phe Val Ile  Val Asp Trp Asp Lys  Ala Thr Pro 
    1670                 1675                 1680             


Gly Asp  Val Val Thr Gly Tyr  Leu Val Tyr Ser Ala  Ser Tyr Glu 
    1685                 1690                 1695             


Asp Phe  Ile Arg Asn Lys Trp  Ser Thr Gln Ala Ser  Ser Val Thr 
    1700                 1705                 1710             


His Leu  Pro Ile Glu Asn Leu  Lys Pro Asn Thr Arg  Tyr Tyr Phe 
    1715                 1720                 1725             


Lys Val  Gln Ala Gln Asn Pro  His Gly Tyr Gly Pro  Ile Ser Pro 
    1730                 1735                 1740             


Ser Val  Ser Phe Val Thr Glu  Ser Asp Asn Pro Leu  Leu Val Val 
    1745                 1750                 1755             


Arg Pro  Pro Gly Gly Glu Pro  Ile Trp Ile Pro Phe  Ala Phe Lys 
    1760                 1765                 1770             


His Asp  Pro Ser Tyr Thr Asp  Cys His Gly Arg Gln  Tyr Val Lys 
    1775                 1780                 1785             


Arg Thr  Trp Tyr Arg Lys Phe  Val Gly Val Val Leu  Cys Asn Ser 
    1790                 1795                 1800             


Leu Arg  Tyr Lys Ile Tyr Leu  Ser Asp Asn Leu Lys  Asp Thr Phe 
    1805                 1810                 1815             


Tyr Ser  Ile Gly Asp Ser Trp  Gly Arg Gly Glu Asp  His Cys Gln 
    1820                 1825                 1830             


Phe Val  Asp Ser His Leu Asp  Gly Arg Thr Gly Pro  Gln Ser Tyr 
    1835                 1840                 1845             


Val Glu  Ala Leu Pro Thr Ile  Gln Gly Tyr Tyr Arg  Gln Tyr Arg 
    1850                 1855                 1860             


Gln Glu  Pro Val Arg Phe Gly  Asn Ile Gly Phe Gly  Thr Pro Tyr 
    1865                 1870                 1875             


Tyr Tyr  Val Gly Trp Tyr Glu  Cys Gly Val Ser Ile  Pro Gly Lys 
    1880                 1885                 1890             


Trp 
    


<210>  5502
<211>  1790
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5502

Xaa Pro Arg His Val Lys Leu Leu Ser Thr Lys Met Gly Leu Lys Val 
1               5                   10                  15      


Thr Trp Asp Pro Pro Lys Asp Ala Thr Ser Arg Pro Val Glu His Tyr 
            20                  25                  30          


Asn Ile Ala Tyr Gly Lys Ser Leu Lys Ser Leu Lys Tyr Ile Lys Val 
        35                  40                  45              


Asn Ala Glu Thr Tyr Ser Phe Leu Ile Glu Asp Val Glu Pro Gly Val 
    50                  55                  60                  


Val Tyr Phe Val Leu Leu Thr Ala Glu Asn His Ser Gly Val Ser Arg 
65                  70                  75                  80  


Pro Val Tyr Arg Ala Glu Ser Pro Pro Gly Gly Glu Trp Ile Glu Ile 
                85                  90                  95      


Asp Gly Phe Pro Ile Lys Gly Pro Gly Pro Phe Asn Glu Thr Val Thr 
            100                 105                 110         


Glu Lys Glu Val Pro Asn Lys Pro Leu Arg Val Arg Val Arg Ser Ser 
        115                 120                 125             


Asp Asp Arg Leu Ser Val Ala Trp Lys Ala Pro Arg Leu Ser Gly Ala 
    130                 135                 140                 


Lys Ser Pro Arg Arg Ser Arg Gly Phe Leu Leu Gly Tyr Gly Glu Ser 
145                 150                 155                 160 


Gly Arg Lys Met Asn Tyr Val Pro Leu Thr Arg Asp Glu Arg Thr His 
                165                 170                 175     


Glu Ile Lys Lys Leu Ala Ser Glu Ser Val Tyr Val Val Ser Leu Gln 
            180                 185                 190         


Ser Met Asn Ser Gln Gly Arg Ser Gln Pro Val Tyr Arg Ala Ala Leu 
        195                 200                 205             


Thr Lys Arg Lys Ile Ser Glu Glu Asp Glu Leu Asp Val Pro Asp Asp 
    210                 215                 220                 


Ile Ser Val Arg Val Met Ser Ser Gln Ser Val Leu Val Ser Trp Val 
225                 230                 235                 240 


Asp Pro Val Leu Glu Lys Gln Lys Lys Val Val Ala Ser Arg Gln Tyr 
                245                 250                 255     


Thr Val Arg Tyr Arg Glu Lys Gly Glu Leu Ala Arg Trp Asp Tyr Lys 
            260                 265                 270         


Gln Ile Ala Asn Arg Arg Val Leu Ile Glu Asn Leu Ile Pro Asp Thr 
        275                 280                 285             


Val Tyr Glu Phe Ala Val Arg Ile Ser Gln Gly Glu Arg Asp Gly Lys 
    290                 295                 300                 


Trp Ser Thr Ser Val Phe Gln Arg Thr Pro Glu Ser Ala Pro Thr Thr 
305                 310                 315                 320 


Ala Pro Glu Asn Leu Asn Val Trp Pro Val Asn Gly Lys Pro Thr Val 
                325                 330                 335     


Val Ala Ala Ser Trp Asp Ala Leu Pro Glu Thr Glu Gly Lys Val Lys 
            340                 345                 350         


Ala Ser Lys Ala Asp Val Glu Gln Asn Thr Glu Asp Asn Gly Lys Pro 
        355                 360                 365             


Glu Lys Pro Glu Pro Ser Ser Pro Ser Pro Arg Ala Pro Ala Ser Ser 
    370                 375                 380                 


Gln His Pro Ser Val Pro Ala Ser Pro Gln Gly Arg Asn Ala Lys Asp 
385                 390                 395                 400 


Leu Leu Leu Asp Leu Lys Asn Lys Ile Leu Ala Asn Gly Gly Ala Pro 
                405                 410                 415     


Arg Lys Pro Gln Leu Arg Ala Lys Lys Ala Glu Glu Leu Asp Leu Gln 
            420                 425                 430         


Ser Thr Glu Ile Thr Gly Glu Glu Glu Leu Gly Ser Arg Glu Asp Ser 
        435                 440                 445             


Pro Met Ser Pro Ser Asp Thr Gln Asp Gln Lys Arg Thr Leu Arg Pro 
    450                 455                 460                 


Pro Ser Arg His Gly His Ser Val Val Ala Pro Gly Arg Thr Ala Val 
465                 470                 475                 480 


Arg Ala Arg Met Pro Ala Leu Pro Arg Arg Glu Gly Val Asp Lys Pro 
                485                 490                 495     


Gly Phe Ser Leu Ala Thr Gln Pro Arg Pro Gly Ala Pro Pro Ser Ala 
            500                 505                 510         


Ser Ala Ser Pro Ala His His Ala Ser Thr Gln Gly Thr Ser His Arg 
        515                 520                 525             


Pro Ser Leu Pro Ala Ser Leu Asn Asp Asn Asp Leu Val Asp Ser Asp 
    530                 535                 540                 


Glu Asp Glu Arg Ala Val Gly Ser Leu His Pro Lys Gly Ala Phe Ala 
545                 550                 555                 560 


Gln Pro Arg Pro Ala Leu Ser Pro Ser Arg Gln Ser Pro Ser Ser Val 
                565                 570                 575     


Leu Arg Asp Arg Ser Ser Val His Pro Gly Ala Lys Pro Ala Ser Pro 
            580                 585                 590         


Ala Arg Arg Thr Pro His Ser Gly Ala Ala Glu Glu Asp Ser Ser Ala 
        595                 600                 605             


Ser Ala Pro Pro Ser Arg Leu Ser Pro Pro His Gly Gly Ser Ser Arg 
    610                 615                 620                 


Leu Leu Pro Thr Gln Pro His Leu Ser Ser Pro Leu Ser Lys Gly Gly 
625                 630                 635                 640 


Lys Asp Gly Glu Asp Ala Pro Ala Thr Asn Ser Asn Ala Pro Ser Arg 
                645                 650                 655     


Ser Thr Met Ser Ser Ser Val Ser Ser His Leu Ser Ser Arg Thr Gln 
            660                 665                 670         


Val Ser Glu Gly Ala Glu Ala Ser Asp Gly Glu Ser His Gly Asp Gly 
        675                 680                 685             


Asp Arg Glu Asp Gly Gly Arg Gln Ala Glu Ala Thr Ala Gln Thr Leu 
    690                 695                 700                 


Arg Ala Arg Pro Ala Ser Gly His Phe His Leu Leu Arg His Lys Pro 
705                 710                 715                 720 


Phe Ala Ala Asn Gly Arg Ser Pro Ser Arg Phe Ser Ile Gly Arg Gly 
                725                 730                 735     


Pro Arg Leu Gln Pro Ser Ser Ser Pro Gln Ser Thr Val Pro Ser Arg 
            740                 745                 750         


Ala His Pro Arg Val Pro Ser His Ser Asp Ser His Pro Lys Leu Ser 
        755                 760                 765             


Ser Gly Ile His Gly Asp Glu Glu Asp Glu Lys Pro Leu Pro Ala Thr 
    770                 775                 780                 


Val Val Asn Asp His Val Pro Ser Ser Ser Arg Gln Pro Ile Ser Arg 
785                 790                 795                 800 


Gly Trp Glu Asp Leu Arg Arg Ser Pro Gln Arg Gly Ala Ser Leu His 
                805                 810                 815     


Arg Lys Glu Pro Ile Pro Glu Asn Pro Lys Ser Thr Gly Ala Asp Thr 
            820                 825                 830         


His Pro Gln Gly Lys Tyr Ser Ser Leu Ala Ser Lys Ala Gln Asp Val 
        835                 840                 845             


Gln Gln Ser Thr Asp Ala Asp Thr Glu Gly His Ser Pro Lys Ala Gln 
    850                 855                 860                 


Pro Gly Ser Thr Asp Arg His Ala Ser Pro Ala Arg Pro Pro Ala Ala 
865                 870                 875                 880 


Arg Ser Gln Gln His Pro Ser Val Pro Arg Arg Met Thr Pro Gly Arg 
                885                 890                 895     


Ala Pro Gln Gln Gln Pro Pro Pro Pro Val Ala Thr Ser Gln His His 
            900                 905                 910         


Pro Gly Pro Gln Ser Arg Asp Ala Gly Arg Ser Pro Ser Gln Pro Arg 
        915                 920                 925             


Leu Ser Leu Thr Gln Ala Gly Arg Pro Arg Pro Thr Ser Gln Gly Arg 
    930                 935                 940                 


Ser His Ser Ser Ser Asp Pro Tyr Thr Ala Ser Ser Arg Gly Met Leu 
945                 950                 955                 960 


Pro Thr Ala Leu Gln Asn Gln Asp Glu Asp Ala Gln Gly Ser Tyr Asp 
                965                 970                 975     


Asp Asp Ser Thr Glu Val Glu Ala Gln Asp Val Arg Ala Pro Ala His 
            980                 985                 990         


Ala Ala Arg Ala Lys Glu Ala Ala  Ala Ser Leu Pro Lys  His Gln Gln 
        995                 1000                 1005             


Val Glu  Ser Pro Thr Gly Ala  Gly Ala Gly Gly Asp  His Arg Ser 
    1010                 1015                 1020             


Gln Arg  Gly His Ala Ala Ser  Pro Ala Arg Pro Ser  Arg Pro Gly 
    1025                 1030                 1035             


Gly Pro  Gln Ser Arg Ala Arg  Val Pro Ser Arg Ala  Ala Pro Gly 
    1040                 1045                 1050             


Lys Ser  Glu Pro Pro Ser Lys  Arg Pro Leu Ser Ser  Lys Ser Gln 
    1055                 1060                 1065             


Gln Ser  Val Ser Ala Glu Asp  Asp Glu Glu Glu Asp  Ala Gly Phe 
    1070                 1075                 1080             


Phe Lys  Gly Gly Lys Glu Asp  Leu Leu Ser Ser Ser  Val Pro Lys 
    1085                 1090                 1095             


Trp Pro  Ser Ser Ser Thr Pro  Arg Gly Gly Lys Asp  Ala Asp Gly 
    1100                 1105                 1110             


Ser Leu  Ala Lys Glu Glu Arg  Glu Pro Ala Ile Ala  Leu Ala Pro 
    1115                 1120                 1125             


Arg Gly  Gly Ser Leu Ala Pro  Val Lys Arg Pro Leu  Pro Pro Pro 
    1130                 1135                 1140             


Pro Gly  Ser Ser Pro Arg Ala  Ser His Val Pro Ser  Arg Leu Pro 
    1145                 1150                 1155             


Pro Arg  Ser Ala Ala Thr Val  Ser Pro Val Ala Gly  Thr His Pro 
    1160                 1165                 1170             


Trp Pro  Gln Tyr Thr Thr Arg  Ala Pro Pro Gly His  Phe Ser Thr 
    1175                 1180                 1185             


Thr Pro  Met Leu Ser Leu Arg  Gln Arg Met Met His  Ala Arg Phe 
    1190                 1195                 1200             


Arg Asn  Pro Leu Ser Arg Gln  Pro Ala Arg Pro Ser  Tyr Arg Gln 
    1205                 1210                 1215             


Gly Tyr  Asn Gly Arg Pro Asn  Val Glu Gly Lys Val  Leu Pro Gly 
    1220                 1225                 1230             


Ser Asn  Gly Lys Pro Asn Gly  Gln Arg Ile Ile Asn  Gly Pro Gln 
    1235                 1240                 1245             


Gly Thr  Lys Trp Val Val Asp  Leu Asp Arg Gly Leu  Val Leu Asn 
    1250                 1255                 1260             


Ala Glu  Gly Arg Tyr Leu Gln  Asp Ser His Gly Asn  Pro Leu Arg 
    1265                 1270                 1275             


Ile Lys  Leu Gly Gly Asp Gly  Arg Thr Ile Val Asp  Leu Glu Gly 
    1280                 1285                 1290             


Thr Pro  Val Val Ser Pro Asp  Gly Leu Pro Leu Phe  Gly Gln Gly 
    1295                 1300                 1305             


Arg His  Gly Thr Pro Leu Ala  Asn Ala Gln Asp Lys  Pro Ile Leu 
    1310                 1315                 1320             


Ser Leu  Gly Gly Lys Pro Leu  Val Gly Leu Glu Val  Ile Lys Lys 
    1325                 1330                 1335             


Thr Thr  His Pro Pro Thr Thr  Thr Met Gln Pro Thr  Thr Thr Thr 
    1340                 1345                 1350             


Thr Pro  Leu Pro Thr Thr Thr  Thr Pro Arg Pro Thr  Thr Ala Thr 
    1355                 1360                 1365             


Thr Arg  Arg Thr Thr Thr Thr  Arg Arg Thr Thr Thr  Arg Arg Pro 
    1370                 1375                 1380             


Thr Thr  Thr Val Arg Thr Thr  Thr Arg Thr Thr Thr  Thr Thr Thr 
    1385                 1390                 1395             


Pro Thr  Pro Thr Thr Pro Ile  Pro Thr Cys Pro Pro  Gly Thr Leu 
    1400                 1405                 1410             


Glu Arg  His Asp Asp Asp Gly  Asn Leu Ile Met Ser  Ser Asn Gly 
    1415                 1420                 1425             


Ile Pro  Glu Cys Tyr Ala Glu  Glu Asp Glu Phe Ser  Gly Leu Glu 
    1430                 1435                 1440             


Thr Asp  Thr Ala Val Pro Thr  Glu Glu Ala Tyr Val  Ile Tyr Asp 
    1445                 1450                 1455             


Glu Asp  Tyr Glu Phe Glu Thr  Ser Arg Pro Pro Thr  Thr Thr Glu 
    1460                 1465                 1470             


Pro Ser  Thr Thr Ala Thr Thr  Pro Arg Val Ile Pro  Glu Glu Gly 
    1475                 1480                 1485             


Ala Ile  Ser Ser Phe Pro Glu  Glu Glu Phe Asp Leu  Ala Gly Arg 
    1490                 1495                 1500             


Lys Arg  Phe Val Ala Pro Tyr  Val Thr Tyr Leu Asn  Lys Asp Pro 
    1505                 1510                 1515             


Ser Ala  Pro Cys Ser Leu Thr  Asp Ala Leu Asp His  Phe Gln Val 
    1520                 1525                 1530             


Asp Ser  Leu Asp Glu Ile Ile  Pro Asn Asp Leu Lys  Lys Ser Asp 
    1535                 1540                 1545             


Leu Pro  Pro Gln His Ala Pro  Arg Asn Ile Thr Val  Val Ala Val 
    1550                 1555                 1560             


Glu Gly  Cys His Ser Phe Val  Ile Val Asp Trp Asp  Lys Ala Thr 
    1565                 1570                 1575             


Pro Gly  Asp Val Val Thr Gly  Tyr Leu Val Tyr Ser  Ala Ser Tyr 
    1580                 1585                 1590             


Glu Asp  Phe Ile Arg Asn Lys  Trp Ser Thr Gln Ala  Ser Ser Val 
    1595                 1600                 1605             


Thr His  Leu Pro Ile Glu Asn  Leu Lys Pro Asn Thr  Arg Tyr Tyr 
    1610                 1615                 1620             


Phe Lys  Val Gln Ala Gln Asn  Pro His Gly Tyr Gly  Pro Ile Ser 
    1625                 1630                 1635             


Pro Ser  Val Ser Phe Val Thr  Glu Ser Asp Asn Pro  Leu Leu Val 
    1640                 1645                 1650             


Val Arg  Pro Pro Gly Gly Glu  Pro Ile Trp Ile Pro  Phe Ala Phe 
    1655                 1660                 1665             


Lys His  Asp Pro Ser Tyr Thr  Asp Cys His Gly Arg  Gln Tyr Val 
    1670                 1675                 1680             


Lys Arg  Thr Trp Tyr Arg Lys  Phe Val Gly Val Val  Leu Cys Asn 
    1685                 1690                 1695             


Ser Leu  Arg Tyr Lys Ile Tyr  Leu Ser Asp Asn Leu  Lys Asp Thr 
    1700                 1705                 1710             


Phe Tyr  Ser Ile Gly Asp Ser  Trp Gly Arg Gly Glu  Asp His Cys 
    1715                 1720                 1725             


Gln Phe  Val Asp Ser His Leu  Asp Gly Arg Thr Gly  Pro Gln Ser 
    1730                 1735                 1740             


Tyr Val  Glu Ala Leu Pro Thr  Ile Gln Gly Tyr Tyr  Arg Gln Tyr 
    1745                 1750                 1755             


Arg Gln  Glu Pro Val Arg Phe  Gly Asn Ile Gly Phe  Gly Thr Pro 
    1760                 1765                 1770             


Tyr Tyr  Tyr Val Gly Trp Tyr  Glu Cys Gly Val Ser  Ile Pro Gly 
    1775                 1780                 1785             


Lys Trp  
    1790 


<210>  5503
<211>  733
<212>  PRT
<213>  Homo Sapiens

<400>  5503

Met Ala Gly Gly Arg Glu Thr Cys Leu Pro Leu Ile Gly Phe Ile Leu 
1               5                   10                  15      


Ile Cys Leu Lys Met Val Ala Ser Ala Lys Ser Ala Pro Glu Ile Pro 
            20                  25                  30          


Thr Ile Asp Gln Ala Tyr Ser Lys Leu Ser Asn Ser Ile Thr Val Glu 
        35                  40                  45              


Trp Ala Thr Val Pro Gly Ala Thr Ser Tyr Leu Leu Thr Ala Glu Asp 
    50                  55                  60                  


Gly Asp Thr Val Ile Glu Thr Thr Val Ala Asn Ser Pro Gly Thr Val 
65                  70                  75                  80  


Thr Gly Leu Lys Ala Ala Thr Trp Tyr Glu Ile Thr Ile Arg Ser Ile 
                85                  90                  95      


Ser Ala Ala Gly Arg Ser Gln Ala Ser Pro Pro Lys Gln Ala Lys Thr 
            100                 105                 110         


Val Leu Ala Ala Pro Ile Leu Glu Val Ser Ser Pro Ser Ser Asp Ser 
        115                 120                 125             


Ile Leu Val Gln Trp Glu Ala Val Tyr Met Ala Ile Ala Phe Ser Val 
    130                 135                 140                 


Ser Ile Met Arg Ala Asn Gly Leu Gly Ser Ile Trp Lys Glu Asn Thr 
145                 150                 155                 160 


Thr Asn Thr Ser Leu Thr Phe Thr Ser Leu Glu Ala Gly Thr Leu Tyr 
                165                 170                 175     


Thr Ile Lys Ala Tyr Ala Trp Asn Ala Asn Arg Ile Pro Gly Asp Asp 
            180                 185                 190         


Ser Thr Cys Asn Gln Arg Thr Ser Pro Arg Ala Pro Ala Asn Ile Gln 
        195                 200                 205             


Val Ser Phe Asp Ser Gly Ala Leu Lys Ala Ser Phe Ser Trp Ala Arg 
    210                 215                 220                 


Ala Glu Gly Ala Phe Asn Tyr Thr Val Met Ala Leu Ser Asp Ser Ser 
225                 230                 235                 240 


Glu Leu Thr Cys Ser Thr Thr Phe Ser Ser Cys Thr Ile Ser Ser Leu 
                245                 250                 255     


Gln Cys Gly Thr Glu Tyr Leu Ile Ser Val Leu Ala Ser Asn Asp Ala 
            260                 265                 270         


Gly Ser Ser Lys Ser Ser Ser Ala Met Thr Leu Lys Thr Val Ala Cys 
        275                 280                 285             


Ala Pro Gly Arg Val Thr Ile Gln Glu Asp Pro Pro Gly His Leu Ser 
    290                 295                 300                 


Val Ala Trp Ser Ser Val Asp Leu Gly Asp Tyr Tyr Val Val Phe Val 
305                 310                 315                 320 


Lys Ser Asp Asp Gly Leu Glu Val His Cys Asn Thr Ser Leu Thr Gln 
                325                 330                 335     


Cys Asn Phe Leu Ser Glu Cys Gly Phe Thr Tyr Phe Ile Ser Val Phe 
            340                 345                 350         


Val Tyr Asn Lys Ala Gly Gln Ser Pro Leu Gly Asp Ile Phe Asn Tyr 
        355                 360                 365             


Thr Thr Ala Pro Cys Cys Pro Ser Asp Ile Asn Pro Val Leu Val Ser 
    370                 375                 380                 


Ser Asp Arg Val Glu Ile Val Trp Ser Pro Val Arg Gly Ala Glu Leu 
385                 390                 395                 400 


Tyr Glu Thr Lys Ala Val Asp Gly Tyr Asn Met Val Glu Cys Asn Asp 
                405                 410                 415     


Thr Thr Pro Ala Cys Thr Leu Ser Ala Leu Glu Cys Asp Thr Lys Tyr 
            420                 425                 430         


Asn Ile Thr Val Tyr Ser Phe Asn Glu Val Arg Gly Ser Asn Met Ser 
        435                 440                 445             


Cys Thr Pro Gln Phe Ile Thr Thr Ala Pro Cys Ser Pro Glu Ile Lys 
    450                 455                 460                 


Asn Val Ser Arg Asp Ala Phe Ser Met Ile Asn Val His Trp Arg Ser 
465                 470                 475                 480 


Thr Asn Asp Asp Ala Thr Tyr Thr Val Thr Ala Gln Gly Glu Lys Gly 
                485                 490                 495     


Leu Tyr Gln Cys Ser Ser Thr Gly Glu Ser Cys Thr Met Arg Gly Leu 
            500                 505                 510         


Pro Cys Gly Ser Val Phe Ser Val Thr Ala Val Ala Glu Thr Gln Ala 
        515                 520                 525             


Gly Arg Ser Leu Pro Ser Tyr Ser Val Pro Leu Glu Thr Val Pro Cys 
    530                 535                 540                 


Cys Pro Thr Gly Leu Thr Val Thr Gln Ile Thr Gln Ser Val Ile Asn 
545                 550                 555                 560 


Val Ser Trp Thr Ile Gly Arg Val Ala Gln Thr His Val Ala Val Leu 
                565                 570                 575     


Glu Ser His Thr Gly Gln Ser Lys Cys His Thr His Gln Asn His Cys 
            580                 585                 590         


Leu Leu Gly Cys Ile Thr Cys Gly Ile Asn Tyr Thr Val Thr Leu Lys 
        595                 600                 605             


Ala Ile Ser Ala Thr Gly Leu Thr Ala Asp Cys Ser Tyr Gln Ser Tyr 
    610                 615                 620                 


Phe Ser Gly Ala Cys Cys Pro Leu Gly Val Lys Leu Tyr Arg Leu Gly 
625                 630                 635                 640 


Pro Asn Gly Ile Arg Ile Tyr Trp Gln Ala Ser Arg Gly Ser Ala Asn 
                645                 650                 655     


Tyr Ser Thr Asp Leu Tyr Gly Ser Lys Gly Ile Phe Thr Cys Thr Pro 
            660                 665                 670         


Ser Ala Gly Leu Ser Phe Cys Asp Val Thr Glu Ile Pro Cys Gly Asp 
        675                 680                 685             


Val Tyr Thr Val Met Val Ser Pro Val Ala Lys Thr Gly Leu Lys Leu 
    690                 695                 700                 


Thr Phe Cys Pro Lys Lys Ile Tyr Ser Val Thr Cys Ser Gly Ser Thr 
705                 710                 715                 720 


Leu Gly Met Val Ile Tyr Arg Gly Lys Arg Asn Glu Glu 
                725                 730             


<210>  5504
<211>  499
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5504

Xaa Glu Gly Ala Phe Asn Tyr Thr Val Met Ala Leu Ser Asp Ser Ser 
1               5                   10                  15      


Glu Leu Thr Cys Ser Thr Thr Phe Ser Ser Cys Thr Ile Ser Ser Leu 
            20                  25                  30          


Gln Cys Gly Thr Glu Tyr Leu Ile Ser Val Leu Ala Ser Asn Asp Ala 
        35                  40                  45              


Gly Ser Ser Lys Ser Ser Ser Ala Met Thr Leu Lys Thr Val Ala Cys 
    50                  55                  60                  


Ala Pro Gly Arg Val Thr Ile Gln Glu Asp Pro Pro Gly His Leu Ser 
65                  70                  75                  80  


Val Ala Trp Ser Ser Val Asp Leu Gly Asp Tyr Tyr Val Val Phe Val 
                85                  90                  95      


Lys Ser Asp Asp Gly Leu Glu Val His Cys Asn Thr Ser Leu Thr Gln 
            100                 105                 110         


Cys Asn Phe Leu Ser Glu Cys Gly Phe Thr Tyr Phe Ile Ser Val Phe 
        115                 120                 125             


Val Tyr Asn Lys Ala Gly Gln Ser Pro Leu Gly Asp Ile Phe Asn Tyr 
    130                 135                 140                 


Thr Thr Ala Pro Cys Cys Pro Ser Asp Ile Asn Pro Val Leu Val Ser 
145                 150                 155                 160 


Ser Asp Arg Val Glu Ile Val Trp Ser Pro Val Arg Gly Ala Glu Leu 
                165                 170                 175     


Tyr Glu Thr Lys Ala Val Asp Gly Tyr Asn Met Val Glu Cys Asn Asp 
            180                 185                 190         


Thr Thr Pro Ala Cys Thr Leu Ser Ala Leu Glu Cys Asp Thr Lys Tyr 
        195                 200                 205             


Asn Ile Thr Val Tyr Ser Phe Asn Glu Val Arg Gly Ser Asn Met Ser 
    210                 215                 220                 


Cys Thr Pro Gln Phe Ile Thr Thr Ala Pro Cys Ser Pro Glu Ile Lys 
225                 230                 235                 240 


Asn Val Ser Arg Asp Ala Phe Ser Met Ile Asn Val His Trp Arg Ser 
                245                 250                 255     


Thr Asn Asp Asp Ala Thr Tyr Thr Val Thr Ala Gln Gly Glu Lys Gly 
            260                 265                 270         


Leu Tyr Gln Cys Ser Ser Thr Gly Glu Ser Cys Thr Met Arg Gly Leu 
        275                 280                 285             


Pro Cys Gly Ser Val Phe Ser Val Thr Ala Val Ala Glu Thr Gln Ala 
    290                 295                 300                 


Gly Arg Ser Leu Pro Ser Tyr Ser Val Pro Leu Glu Thr Val Pro Cys 
305                 310                 315                 320 


Cys Pro Thr Gly Leu Thr Val Thr Gln Ile Thr Gln Ser Val Ile Asn 
                325                 330                 335     


Val Ser Trp Thr Ile Gly Arg Val Ala Gln Thr His Val Ala Val Leu 
            340                 345                 350         


Glu Ser His Thr Gly Gln Ser Lys Cys His Thr His Gln Asn His Cys 
        355                 360                 365             


Leu Leu Gly Cys Ile Thr Cys Gly Ile Asn Tyr Thr Val Thr Leu Lys 
    370                 375                 380                 


Ala Ile Ser Ala Thr Gly Leu Thr Ala Asp Cys Ser Tyr Gln Ser Tyr 
385                 390                 395                 400 


Phe Ser Gly Ala Cys Cys Pro Leu Gly Val Lys Leu Tyr Arg Leu Gly 
                405                 410                 415     


Pro Asn Gly Ile Arg Ile Tyr Trp Gln Ala Ser Arg Gly Ser Ala Asn 
            420                 425                 430         


Tyr Ser Thr Asp Leu Tyr Gly Ser Lys Gly Ile Phe Thr Cys Thr Pro 
        435                 440                 445             


Ser Ala Gly Leu Ser Phe Cys Asp Val Thr Glu Ile Pro Cys Gly Asp 
    450                 455                 460                 


Val Tyr Thr Val Met Val Ser Pro Val Ala Lys Thr Gly Leu Lys Leu 
465                 470                 475                 480 


Thr Phe Cys Pro Lys Lys Ile Tyr Ser Val Ile Tyr Arg Gly Lys Arg 
                485                 490                 495     


Asn Glu Glu 
            


<210>  5505
<211>  46
<212>  PRT
<213>  Homo Sapiens

<400>  5505

Met Ala Val Ser Asp Val Pro Ser Leu Ser Val Gly Lys Glu Val Gln 
1               5                   10                  15      


Trp Glu Lys Leu Ile Ala Lys Ala Ala Ser Ile Arg Asp Ile Cys His 
            20                  25                  30          


Ile Asn Met Val Gln Ile Cys Trp Gln Leu Phe Leu Lys Cys 
        35                  40                  45      


<210>  5506
<211>  1237
<212>  PRT
<213>  Homo Sapiens

<400>  5506

Met Ala Val Ser Asp Val Pro Ser Leu Ser Val Gly Lys Glu Val Gln 
1               5                   10                  15      


Trp Glu Lys Leu Ile Ala Lys Ala Ala Ser Ile Arg Asp Ile Cys Lys 
            20                  25                  30          


Gln Arg Pro Tyr Gln His Gly Ala Asp Met Leu Ala Ala Ile Ser Gln 
        35                  40                  45              


Val Leu Asn Glu Cys Thr Lys Pro Asp Gln Ala Thr Pro Ala Ala Leu 
    50                  55                  60                  


Val Leu Gln Gly Leu His Ala Leu Cys Gln Ala Glu Val Val Cys Ile 
65                  70                  75                  80  


Arg Ser Thr Trp Asn Ala Leu Ser Pro Lys Leu Ser Cys Asp Thr Arg 
                85                  90                  95      


Pro Leu Ile Leu Lys Thr Leu Ser Glu Leu Phe Ser Leu Val Pro Ser 
            100                 105                 110         


Leu Thr Val Asn Thr Thr Glu Tyr Glu Asn Phe Lys Val Gln Val Leu 
        115                 120                 125             


Ser Phe Leu Trp Thr His Thr Gln Asn Lys Asp Pro Ile Val Ala Asn 
    130                 135                 140                 


Ala Ala Tyr Arg Ser Leu Ala Asn Phe Ser Ala Gly Glu His Thr Ile 
145                 150                 155                 160 


Leu His Leu Pro Glu Lys Ile Arg Pro Glu Ile Pro Ile Pro Glu Glu 
                165                 170                 175     


Leu Asp Asp Asp Glu Asp Val Glu Asp Val Asp Leu Ser Val Pro Gly 
            180                 185                 190         


Ser Cys Tyr Leu Lys Leu Leu Ser Leu Thr Pro Pro Leu Val Leu Pro 
        195                 200                 205             


Ala Leu Glu Glu Phe Phe Thr Ser Leu Val Lys Gln Glu Met Val Asn 
    210                 215                 220                 


Met Pro Arg Gly Ile Tyr His Ser Ala Leu Lys Gly Gly Ala Arg Ser 
225                 230                 235                 240 


Asp Gln Gly Lys Thr Val Ala Gly Ile Pro Asn Phe Ile Leu Lys Met 
                245                 250                 255     


Tyr Glu Thr Asn Lys Gln Pro Gly Leu Lys Pro Gly Leu Ala Gly Gly 
            260                 265                 270         


Met Leu Phe Cys Tyr Asp Val Ser Met Tyr Gln Ser Lys Asp Gly Lys 
        275                 280                 285             


Pro Leu Asn Arg Leu Met Ala Ser Arg Gly Arg Ser Phe Lys Gln Thr 
    290                 295                 300                 


Ser Leu Ala Leu Val His Glu Val His Ile Gln Leu Ser Glu Trp His 
305                 310                 315                 320 


Arg Ala Ile Phe Leu Pro Gln Ala Trp Leu Ala Tyr Met Asn Arg Ala 
                325                 330                 335     


Tyr His Ala Ile Leu Gln Gly Arg Leu Gly Glu Leu Glu Leu Gln Leu 
            340                 345                 350         


Lys His Gly Lys Glu Glu Pro Glu Glu Val Gln Tyr Lys Lys Ser Thr 
        355                 360                 365             


Ala Trp Leu Trp Val Arg Asp Met Leu Thr Asp Glu Ile Thr Lys Ala 
    370                 375                 380                 


Ala Ala Lys Glu Ser Pro Val Val Lys Gly Asn Ala Leu Leu Ala Leu 
385                 390                 395                 400 


Ser Ser Leu Ala Val Val Val Ser Arg His Glu Ala Ser Leu Ser Ser 
                405                 410                 415     


Asp Ser Asp Gly Leu Leu Glu Val Gln Pro Asn Phe Leu Ser Met Lys 
            420                 425                 430         


Glu Trp Val Ser Met Val Leu Asp Thr Leu Leu Val Ile Val Asp Ser 
        435                 440                 445             


His Tyr Gln Pro Arg Gly Gln Leu Leu Ser Trp Phe Tyr Tyr Lys Ser 
    450                 455                 460                 


Tyr Ser Gly Glu Asn Thr Ala Ser Ala Ile Ala Arg Ser Ala Ala Ala 
465                 470                 475                 480 


Thr Ala Leu Ser Leu Leu Val Pro Val Phe Ile Ile Ser Cys Lys Glu 
                485                 490                 495     


Lys Val Glu Glu Ile Leu Asn Met Leu Thr Ala Arg Leu Pro Gly Lys 
            500                 505                 510         


Pro Ser Ala Asp Glu Ser Gln Ala Val Gln Ile His Met Gly Leu Ala 
        515                 520                 525             


Leu Gly Met Phe Leu Ser Arg Leu Cys Glu Glu Lys Leu Ser Asp Ile 
    530                 535                 540                 


Ser Gly Gln Glu Met Asn Leu Leu Leu Met Lys Ser Leu Asp Ala Leu 
545                 550                 555                 560 


Glu Asn Cys Cys Phe Asp Thr Ser Leu Glu Tyr Asn Thr Gly Cys Ile 
                565                 570                 575     


Leu Gly Val Gly Leu Val Leu Ser Leu Met Ser His Ser Ser Gln Met 
            580                 585                 590         


Gln Ser Arg Val His Val Ala Ala Leu Leu Arg Lys Leu Ser Ala His 
        595                 600                 605             


Val Asp Asp Ser Gly Ser Gln Ser Arg Thr Phe Gln Glu Val Leu Ala 
    610                 615                 620                 


Tyr Thr Leu Ser Cys Val Cys Thr Ser Ala Phe Ser Ala Gly Ile Ile 
625                 630                 635                 640 


Glu Ala Thr Glu Ala Glu Asp Val Met Asn Lys Leu Arg Leu Leu Val 
                645                 650                 655     


Glu Asn Ser Gln Gln Thr Ser Gly Phe Ala Leu Ala Leu Gly Asn Ile 
            660                 665                 670         


Val His Gly Leu Ser Val Cys Gly His Gly Lys Ala Glu Asp Leu Gly 
        675                 680                 685             


Ser Lys Leu Leu Pro Ala Trp Ile Arg Ile Val Leu Thr Glu Gly Thr 
    690                 695                 700                 


Pro Thr Met Leu Cys Leu Ala Ala Leu His Gly Met Val Ala Leu Val 
705                 710                 715                 720 


Gly Ser Glu Gly Asp Val Met Gln Leu Lys Ser Glu Ala Ile Gln Thr 
                725                 730                 735     


Ser His Phe Gln Gly Arg Leu Asn Glu Val Ile Arg Thr Leu Thr Gln 
            740                 745                 750         


Val Ile Ser Val Ser Gly Val Ile Gly Leu Gln Ser Asn Ala Val Trp 
        755                 760                 765             


Leu Leu Gly His Leu His Leu Ser Thr Leu Ser Ser Ser Gln Ser Arg 
    770                 775                 780                 


Ala Ser Val Pro Thr Asp Tyr Ser Tyr Leu Pro Glu Ser Ser Phe Ile 
785                 790                 795                 800 


Gly Ala Ala Ile Gly Phe Phe Ile Thr Gly Gly Lys Lys Gly Pro Glu 
                805                 810                 815     


Ser Val Pro Pro Ser Leu Leu Lys Val Val Met Lys Pro Ile Ala Thr 
            820                 825                 830         


Val Gly Glu Ser Tyr Gln Tyr Pro Pro Val Asn Trp Ala Ala Leu Leu 
        835                 840                 845             


Ser Pro Leu Met Arg Leu Asn Phe Gly Glu Glu Ile Gln Gln Leu Cys 
    850                 855                 860                 


Leu Glu Ile Met Val Thr Gln Ala Gln Ser Ser Gln Asn Ala Ala Ala 
865                 870                 875                 880 


Leu Leu Gly Leu Trp Val Thr Pro Pro Leu Ile His Ser Leu Ser Leu 
                885                 890                 895     


Asn Thr Lys Arg Tyr Leu Leu Ile Ser Ala Pro Leu Trp Ile Lys His 
            900                 905                 910         


Ile Ser Asp Glu Gln Ile Leu Gly Phe Val Glu Asn Leu Met Val Ala 
        915                 920                 925             


Val Phe Lys Ala Ala Ser Pro Leu Gly Ser Pro Glu Leu Cys Pro Ser 
    930                 935                 940                 


Ala Leu His Gly Leu Ser Gln Ala Met Lys Leu Pro Ser Pro Ala His 
945                 950                 955                 960 


His Leu Trp Ser Leu Leu Ser Glu Ala Thr Gly Lys Ile Phe Asp Leu 
                965                 970                 975     


Leu Pro Asn Lys Ile Arg Arg Lys Asp Leu Glu Leu Tyr Ile Ser Ile 
            980                 985                 990         


Ala Lys Cys Leu Leu Glu Met Thr  Asp Asp Asp Ala Asn  Arg Ile Ala 
        995                 1000                 1005             


Gln Val  Thr Lys Ser Asn Ile  Glu Lys Ala Ala Phe  Val Lys Leu 
    1010                 1015                 1020             


Tyr Leu  Val Ser Gln Gly Arg  Phe Pro Leu Val Asn  Leu Thr Asp 
    1025                 1030                 1035             


Met Leu  Ser Val Ala Val Gln  His Arg Glu Lys Glu  Val Leu Ala 
    1040                 1045                 1050             


Trp Met  Ile Leu His Ser Leu  Tyr Gln Ala Arg Ile  Val Ser His 
    1055                 1060                 1065             


Ala Asn  Thr Gly Val Leu Lys  Arg Met Glu Trp Leu  Leu Glu Leu 
    1070                 1075                 1080             


Met Gly  Tyr Ile Arg Asn Val  Ala Tyr Gln Ser Thr  Ser Phe His 
    1085                 1090                 1095             


Asn Thr  Ala Leu Asp Lys Ala  Leu Asp Phe Phe Leu  Leu Ile Phe 
    1100                 1105                 1110             


Ala Thr  Ala Val Val Ala Trp  Ala Asp His Thr Ala  Pro Leu Leu 
    1115                 1120                 1125             


Leu Gly  Leu Ser Ala Ser Trp  Leu Pro Trp His Gln  Glu Asn Gly 
    1130                 1135                 1140             


Pro Ala  Gly Pro Val Pro Ser  Phe Leu Gly Arg Ser  Pro Met His 
    1145                 1150                 1155             


Arg Val  Thr Leu Gln Glu Val  Leu Thr Leu Leu Pro  Asn Ser Met 
    1160                 1165                 1170             


Ala Leu  Leu Leu Gln Lys Glu  Pro Trp Lys Glu Gln  Thr Gln Lys 
    1175                 1180                 1185             


Phe Ile  Asp Trp Leu Phe Ser  Ile Met Glu Ser Pro  Lys Glu Ala 
    1190                 1195                 1200             


Leu Ser  Ala Gln Ser Arg Asp  Leu Leu Lys Ala Thr  Leu Leu Ser 
    1205                 1210                 1215             


Leu Arg  Val Leu Pro Glu Phe  Lys Lys Lys Ala Val  Trp Thr Arg 
    1220                 1225                 1230             


Ala Tyr  Gly Trp 
    1235         


<210>  5507
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  5507

Met Leu Thr Ala Arg Leu Pro Gly Lys Pro Ser Ala Asp Glu Ser Gln 
1               5                   10                  15      


Ala Val Gln Ile His Met Gly Leu Ala Leu Gly Met Phe Leu Ser Arg 
            20                  25                  30          


Leu Cys Glu Glu Lys Leu Ser Asp Ile Ser Gly Gln Glu Met Asn Leu 
        35                  40                  45              


Leu Leu Met Lys Ser Leu Asp Ala Leu Glu Asn Cys Cys Phe Asp Thr 
    50                  55                  60                  


Ser Leu Glu Tyr Asn Thr Gly Cys Ile Leu Gly Val Gly Leu Val Leu 
65                  70                  75                  80  


Ser Leu Met Ser His Ser Ser Gln Met Gln Ser Arg Val His Val Ala 
                85                  90                  95      


Ala Leu Leu 
            


<210>  5508
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  5508

Met Leu Thr Ala Arg Leu Pro Gly Lys Pro Ser Ala Asp Glu Ser Gln 
1               5                   10                  15      


Ala Val Gln Ile His Met Gly Leu Ala Leu Gly Met Phe Leu Ser Arg 
            20                  25                  30          


Leu Cys Glu Glu Lys Leu Ser Asp Ile Ser Gly Gln Glu Met Asn Leu 
        35                  40                  45              


Leu Leu Met Lys Ser Leu Asp Ala Leu Glu Asn Cys Cys Phe Asp Thr 
    50                  55                  60                  


Ser Leu Glu Tyr Asn Thr Gly Cys Ile Leu Gly Val Gly Leu Val Leu 
65                  70                  75                  80  


Ser Leu Met Ser His Ser Ser Gln Met Gln Ser Arg Val His Val Ala 
                85                  90                  95      


Ala Leu Leu Arg Lys Leu Ser Ala His Val Asp Asp Ser Gly Ser Gln 
            100                 105                 110         


Ser Arg Thr Phe Gln Glu Val Leu Ala Tyr Thr Leu Ser Cys Val Cys 
        115                 120                 125             


<210>  5509
<211>  180
<212>  PRT
<213>  Homo Sapiens

<400>  5509

Met Pro Lys Val Phe Ser Val Tyr Phe Val Cys Leu Cys Pro Ala Leu 
1               5                   10                  15      


Gly Lys Ile Cys Asp Ile Ser Gly Gln Glu Met Asn Leu Leu Leu Met 
            20                  25                  30          


Lys Ser Leu Asp Ala Leu Glu Asn Cys Cys Phe Asp Thr Ser Leu Glu 
        35                  40                  45              


Tyr Asn Thr Gly Cys Ile Leu Gly Val Gly Leu Val Leu Ser Leu Met 
    50                  55                  60                  


Ser His Ser Ser Gln Met Gln Ser Arg Val His Val Ala Ala Leu Leu 
65                  70                  75                  80  


Arg Lys Leu Ser Ala His Val Asp Asp Ser Gly Ser Gln Ser Arg Thr 
                85                  90                  95      


Phe Gln Glu Val Leu Ala Tyr Thr Leu Ser Cys Val Cys Thr Ser Ala 
            100                 105                 110         


Phe Ser Ala Gly Ile Ile Glu Ala Thr Glu Ala Glu Asp Val Met Asn 
        115                 120                 125             


Lys Leu Arg Leu Leu Val Glu Asn Ser Gln Gln Thr Ser Gly Phe Ala 
    130                 135                 140                 


Leu Ala Leu Gly Asn Ile Val His Gly Leu Ser Val Cys Gly His Gly 
145                 150                 155                 160 


Lys Ala Glu Asp Leu Gly Ser Lys Leu Leu Pro Ala Trp Ile Arg Ile 
                165                 170                 175     


Val Leu Thr Glu 
            180 


<210>  5510
<211>  1801
<212>  PRT
<213>  Homo Sapiens

<400>  5510

Met Ser Asp Asp Ile Arg Lys Arg Phe Glu Phe Pro Asn Ser Leu Ile 
1               5                   10                  15      


Gln Ser Gln Ala Val Gly His Leu Ile Ala Ala Val Leu Lys Glu Asn 
            20                  25                  30          


Gly Phe Ser Glu Lys Ile His Gln Ser Thr Asn Gln Thr Pro Ala Leu 
        35                  40                  45              


Asn Leu Leu Trp Glu Lys Cys Cys Ser Asp Asn Val Val Val Arg Thr 
    50                  55                  60                  


Ala Cys Cys Glu Gly Leu Val Ala Leu Val Ala Gln Asp His Ala Glu 
65                  70                  75                  80  


Phe Ser Tyr Val Leu Asn Gly Ile Leu Asn Leu Ile Pro Ser Thr Arg 
                85                  90                  95      


Asn Thr His Gly Leu Ile Lys Ala Ile Met His Leu Leu Gln Met Gln 
            100                 105                 110         


Ala Leu Lys Glu Gly Gln Gly Gly Glu Lys Asn Ile Gln Ser Ile Tyr 
        115                 120                 125             


Thr Ile Arg Asn His Pro His Pro Leu Ile Thr Val Leu Glu His Arg 
    130                 135                 140                 


Pro Asp Cys Trp Pro Val Phe Leu Gln Gln Leu Thr Ala Phe Phe Gln 
145                 150                 155                 160 


Gln Cys Pro Glu Arg Leu Glu Val Ser Cys Ile Gln Ile Met Ala Pro 
                165                 170                 175     


Phe Leu Trp Tyr Leu Tyr Cys Glu Pro Ser Gln Leu Gln Glu Tyr Ala 
            180                 185                 190         


Lys Leu Arg Leu Ala Leu Leu Lys Val Leu Leu Gln Pro Gln Val Leu 
        195                 200                 205             


Cys Asp Lys Asp Gln Pro Ser Ile Leu Glu Gln Gln Ile Leu Gln Leu 
    210                 215                 220                 


Cys Cys Asp Ile Val Pro Cys Leu Gln Val Lys Asp Leu Ile Gln Thr 
225                 230                 235                 240 


Thr Glu Ala Met Met Phe Ile Glu Glu Val Cys Leu Ser Leu Leu Arg 
                245                 250                 255     


His Pro Val Phe Trp Lys Ile Gln Leu Thr Gln Met Ser Leu Gln Leu 
            260                 265                 270         


Leu Cys Val Ser Glu Val Ser Leu Lys Ile Thr Gly Glu Cys Ser Ser 
        275                 280                 285             


Ser Ile His Leu Leu Glu His Ser Val Glu Leu Leu Lys Glu Asp Phe 
    290                 295                 300                 


Pro Val Glu Leu Val Ile Ile Gly Ile Ala Leu Leu Leu Leu Gln Thr 
305                 310                 315                 320 


Pro Ala Ser Gln Gln Lys Pro Ile Leu Asn Leu Ala Leu Lys Leu Leu 
                325                 330                 335     


Ser Val Thr Glu Asp Gln Lys Ile Pro Lys Ser Ser Leu Leu Leu Val 
            340                 345                 350         


Met Pro Ile Leu Gln Ile Leu Ser Ser Thr Ala Leu Glu Asp Cys Ile 
        355                 360                 365             


Ser Val Asp Glu Glu Gly Pro Ser Arg Gln Gln Leu Ala Leu Asn Leu 
    370                 375                 380                 


Leu Glu Met Ile Gln Gln Glu Cys Tyr Arg Asp Asp His Gln Lys Leu 
385                 390                 395                 400 


Ser Tyr Lys Leu Val Cys Pro Val Thr Ser Met Tyr Gly Thr Ile Phe 
                405                 410                 415     


Thr Ala Trp Arg Ile Leu Glu Val Met Thr Asp Ser Ser Ala Ala Ser 
            420                 425                 430         


Asp Trp Leu Ala Ser Val Glu Ser Leu Leu Pro Ile Thr Ala Val Ile 
        435                 440                 445             


Pro Ala Pro Ala Phe Leu Leu Leu Ala His Leu Leu Val Glu Asp Lys 
    450                 455                 460                 


Gly Gln Asn Leu His Gln Ile Leu Lys Val Thr Thr Glu Leu Ala Gln 
465                 470                 475                 480 


Ala Asp Ser Ser Gln Val Pro Asn Leu Ile Pro Val Leu Met Phe Lys 
                485                 490                 495     


Leu Gly Arg Pro Leu Glu Pro Ile Leu Tyr Asn Asp Ile Leu Tyr Thr 
            500                 505                 510         


Leu Pro Lys Leu Gly Val His Lys Val Cys Ile Gly Gln Ile Leu Arg 
        515                 520                 525             


Ile Ile Gln Leu Leu Gly Thr Thr Pro Arg Leu Arg Ala Val Thr Leu 
    530                 535                 540                 


Arg Leu Leu Thr Ser Leu Trp Glu Lys Gln Asp Arg Val Tyr Pro Glu 
545                 550                 555                 560 


Leu Gln Arg Phe Met Ala Val Ser Asp Val Pro Ser Leu Ser Val Gly 
                565                 570                 575     


Lys Glu Val Gln Trp Glu Lys Leu Ile Ala Lys Ala Ala Ser Ile Arg 
            580                 585                 590         


Asp Ile Cys Lys Gln Arg Pro Tyr Gln His Gly Ala Asp Met Leu Ala 
        595                 600                 605             


Ala Ile Ser Gln Val Leu Asn Glu Cys Thr Lys Pro Asp Gln Ala Thr 
    610                 615                 620                 


Pro Ala Ala Leu Val Leu Gln Gly Leu His Ala Leu Cys Gln Ala Glu 
625                 630                 635                 640 


Val Val Cys Ile Arg Ser Thr Trp Asn Ala Leu Ser Pro Lys Leu Ser 
                645                 650                 655     


Cys Asp Thr Arg Pro Leu Ile Leu Lys Thr Leu Ser Glu Leu Phe Ser 
            660                 665                 670         


Leu Val Pro Ser Leu Thr Val Asn Thr Thr Glu Tyr Glu Asn Phe Lys 
        675                 680                 685             


Val Gln Val Leu Ser Phe Leu Trp Thr His Thr Gln Asn Lys Asp Pro 
    690                 695                 700                 


Ile Val Ala Asn Ala Ala Tyr Arg Ser Leu Ala Asn Phe Ser Ala Gly 
705                 710                 715                 720 


Glu His Thr Ile Leu His Leu Pro Glu Lys Ile Arg Pro Glu Ile Pro 
                725                 730                 735     


Ile Pro Glu Glu Leu Asp Asp Asp Glu Asp Val Glu Asp Val Asp Leu 
            740                 745                 750         


Ser Val Pro Gly Ser Cys Tyr Leu Lys Leu Leu Ser Leu Thr Pro Pro 
        755                 760                 765             


Leu Val Leu Pro Ala Leu Glu Glu Phe Phe Thr Ser Leu Val Lys Gln 
    770                 775                 780                 


Glu Met Val Asn Met Pro Arg Gly Ile Tyr His Ser Ala Leu Lys Gly 
785                 790                 795                 800 


Gly Ala Arg Ser Asp Gln Gly Lys Thr Val Ala Gly Ile Pro Asn Phe 
                805                 810                 815     


Ile Leu Lys Met Tyr Glu Thr Asn Lys Gln Pro Gly Leu Lys Pro Gly 
            820                 825                 830         


Leu Ala Gly Gly Met Leu Phe Cys Tyr Asp Val Ser Met Tyr Gln Ser 
        835                 840                 845             


Lys Asp Gly Lys Pro Leu Asn Arg Leu Met Ala Ser Arg Gly Arg Ser 
    850                 855                 860                 


Phe Lys Gln Thr Ser Leu Ala Leu Val His Glu Val His Ile Gln Leu 
865                 870                 875                 880 


Ser Glu Trp His Arg Ala Ile Phe Leu Pro Gln Ala Trp Leu Ala Tyr 
                885                 890                 895     


Met Asn Arg Ala Tyr His Ala Ile Leu Gln Gly Arg Leu Gly Glu Leu 
            900                 905                 910         


Glu Leu Gln Leu Lys His Gly Lys Glu Glu Pro Glu Glu Val Gln Tyr 
        915                 920                 925             


Lys Lys Ser Thr Ala Trp Leu Trp Val Arg Asp Met Leu Thr Asp Glu 
    930                 935                 940                 


Ile Thr Lys Ala Ala Ala Lys Glu Ser Pro Val Val Lys Gly Asn Ala 
945                 950                 955                 960 


Leu Leu Ala Leu Ser Ser Leu Ala Val Val Val Ser Arg His Glu Ala 
                965                 970                 975     


Ser Leu Ser Ser Asp Ser Asp Gly Leu Leu Glu Val Gln Pro Asn Phe 
            980                 985                 990         


Leu Ser Met Lys Glu Trp Val Ser  Met Val Leu Asp Thr  Leu Leu Val 
        995                 1000                 1005             


Ile Val  Asp Ser His Tyr Gln  Pro Arg Gly Gln Leu  Leu Ser Trp 
    1010                 1015                 1020             


Phe Tyr  Tyr Lys Ser Tyr Ser  Gly Glu Asn Thr Ala  Ser Ala Ile 
    1025                 1030                 1035             


Ala Arg  Ser Ala Ala Ala Thr  Ala Leu Ser Leu Leu  Val Pro Val 
    1040                 1045                 1050             


Phe Ile  Ile Ser Cys Lys Glu  Lys Val Glu Glu Ile  Leu Asn Met 
    1055                 1060                 1065             


Leu Thr  Ala Arg Leu Pro Gly  Lys Pro Ser Ala Asp  Glu Ser Gln 
    1070                 1075                 1080             


Ala Val  Gln Ile His Met Gly  Leu Ala Leu Gly Met  Phe Leu Ser 
    1085                 1090                 1095             


Arg Leu  Cys Glu Glu Lys Leu  Ser Asp Ile Ser Gly  Gln Glu Met 
    1100                 1105                 1110             


Asn Leu  Leu Leu Met Lys Ser  Leu Asp Ala Leu Glu  Asn Cys Cys 
    1115                 1120                 1125             


Phe Asp  Thr Ser Leu Glu Tyr  Asn Thr Gly Cys Ile  Leu Gly Val 
    1130                 1135                 1140             


Gly Leu  Val Leu Ser Leu Met  Ser His Ser Ser Gln  Met Gln Ser 
    1145                 1150                 1155             


Arg Val  His Val Ala Ala Leu  Leu Arg Lys Leu Ser  Ala His Val 
    1160                 1165                 1170             


Asp Asp  Ser Gly Ser Gln Ser  Arg Thr Phe Gln Glu  Val Leu Ala 
    1175                 1180                 1185             


Tyr Thr  Leu Ser Cys Val Cys  Thr Ser Ala Phe Ser  Ala Gly Ile 
    1190                 1195                 1200             


Ile Glu  Ala Thr Glu Ala Glu  Asp Val Met Asn Lys  Leu Arg Leu 
    1205                 1210                 1215             


Leu Val  Glu Asn Ser Gln Gln  Thr Ser Gly Phe Ala  Leu Ala Leu 
    1220                 1225                 1230             


Gly Asn  Ile Val His Gly Leu  Ser Val Cys Gly His  Gly Lys Ala 
    1235                 1240                 1245             


Glu Asp  Leu Gly Ser Lys Leu  Leu Pro Ala Trp Ile  Arg Ile Val 
    1250                 1255                 1260             


Leu Thr  Glu Gly Thr Pro Thr  Met Leu Cys Leu Ala  Ala Leu His 
    1265                 1270                 1275             


Gly Met  Val Ala Leu Val Gly  Ser Glu Gly Asp Val  Met Gln Leu 
    1280                 1285                 1290             


Lys Ser  Glu Ala Ile Gln Thr  Ser His Phe Gln Gly  Arg Leu Asn 
    1295                 1300                 1305             


Glu Val  Ile Arg Thr Leu Thr  Gln Val Ile Ser Val  Ser Gly Val 
    1310                 1315                 1320             


Ile Gly  Leu Gln Ser Asn Ala  Val Trp Leu Leu Gly  His Leu His 
    1325                 1330                 1335             


Leu Ser  Thr Leu Ser Ser Ser  Gln Ser Arg Ala Ser  Val Pro Thr 
    1340                 1345                 1350             


Asp Tyr  Ser Tyr Leu Pro Glu  Ser Ser Phe Ile Gly  Ala Ala Ile 
    1355                 1360                 1365             


Gly Phe  Phe Ile Thr Gly Gly  Lys Lys Gly Pro Glu  Ser Val Pro 
    1370                 1375                 1380             


Pro Ser  Leu Leu Lys Val Val  Met Lys Pro Ile Ala  Thr Val Gly 
    1385                 1390                 1395             


Glu Ser  Tyr Gln Tyr Pro Pro  Val Asn Trp Ala Ala  Leu Leu Ser 
    1400                 1405                 1410             


Pro Leu  Met Arg Leu Asn Phe  Gly Glu Glu Ile Gln  Gln Leu Cys 
    1415                 1420                 1425             


Leu Glu  Ile Met Val Thr Gln  Ala Gln Ser Ser Gln  Asn Ala Ala 
    1430                 1435                 1440             


Ala Leu  Leu Gly Leu Trp Val  Thr Pro Pro Leu Ile  His Ser Leu 
    1445                 1450                 1455             


Ser Leu  Asn Thr Lys Arg Tyr  Leu Leu Ile Ser Ala  Pro Leu Trp 
    1460                 1465                 1470             


Ile Lys  His Ile Ser Asp Glu  Gln Ile Leu Gly Phe  Val Glu Asn 
    1475                 1480                 1485             


Leu Met  Val Ala Val Phe Lys  Ala Ala Ser Pro Leu  Gly Ser Pro 
    1490                 1495                 1500             


Glu Leu  Cys Pro Ser Ala Leu  His Gly Leu Ser Gln  Ala Met Lys 
    1505                 1510                 1515             


Leu Pro  Ser Pro Ala His His  Leu Trp Ser Leu Leu  Ser Glu Ala 
    1520                 1525                 1530             


Thr Gly  Lys Ile Phe Asp Leu  Leu Pro Asn Lys Ile  Arg Arg Lys 
    1535                 1540                 1545             


Asp Leu  Glu Leu Tyr Ile Ser  Ile Ala Lys Cys Leu  Leu Glu Met 
    1550                 1555                 1560             


Thr Asp  Asp Asp Ala Asn Arg  Ile Ala Gln Val Thr  Lys Ser Asn 
    1565                 1570                 1575             


Ile Glu  Lys Ala Ala Phe Val  Lys Leu Tyr Leu Val  Ser Gln Gly 
    1580                 1585                 1590             


Arg Phe  Pro Leu Val Asn Leu  Thr Asp Met Leu Ser  Val Ala Val 
    1595                 1600                 1605             


Gln His  Arg Glu Lys Glu Val  Leu Ala Trp Met Ile  Leu His Ser 
    1610                 1615                 1620             


Leu Tyr  Gln Ala Arg Ile Val  Ser His Ala Asn Thr  Gly Val Leu 
    1625                 1630                 1635             


Lys Arg  Met Glu Trp Leu Leu  Glu Leu Met Gly Tyr  Ile Arg Asn 
    1640                 1645                 1650             


Val Ala  Tyr Gln Ser Thr Ser  Phe His Asn Thr Ala  Leu Asp Lys 
    1655                 1660                 1665             


Ala Leu  Asp Phe Phe Leu Leu  Ile Phe Ala Thr Ala  Val Val Ala 
    1670                 1675                 1680             


Trp Ala  Asp His Thr Ala Pro  Leu Leu Leu Gly Leu  Ser Ala Ser 
    1685                 1690                 1695             


Trp Leu  Pro Trp His Gln Glu  Asn Gly Pro Ala Gly  Pro Val Pro 
    1700                 1705                 1710             


Ser Phe  Leu Gly Arg Ser Pro  Met His Arg Val Thr  Leu Gln Glu 
    1715                 1720                 1725             


Val Leu  Thr Leu Leu Pro Asn  Ser Met Ala Leu Leu  Leu Gln Lys 
    1730                 1735                 1740             


Glu Pro  Trp Lys Glu Gln Thr  Gln Lys Phe Ile Asp  Trp Leu Phe 
    1745                 1750                 1755             


Ser Ile  Met Glu Ser Pro Lys  Glu Ala Leu Ser Ala  Gln Ser Arg 
    1760                 1765                 1770             


Asp Leu  Leu Lys Ala Thr Leu  Leu Ser Leu Arg Val  Leu Pro Glu 
    1775                 1780                 1785             


Phe Lys  Lys Lys Ala Val Trp  Thr Arg Ala Tyr Gly  Trp 
    1790                 1795                 1800     


<210>  5511
<211>  1801
<212>  PRT
<213>  Homo Sapiens

<400>  5511

Met Ser Asp Asp Ile Arg Lys Arg Phe Glu Phe Pro Asn Ser Leu Ile 
1               5                   10                  15      


Gln Ser Gln Ala Val Gly His Leu Ile Ala Ala Val Leu Lys Glu Asn 
            20                  25                  30          


Gly Phe Ser Glu Lys Ile His Gln Ser Thr Asn Gln Thr Pro Ala Leu 
        35                  40                  45              


Asn Leu Leu Trp Glu Lys Cys Cys Ser Asp Asn Val Val Val Arg Thr 
    50                  55                  60                  


Ala Cys Cys Glu Gly Leu Val Ala Leu Val Ala Gln Asp His Ala Glu 
65                  70                  75                  80  


Phe Ser Tyr Val Leu Asn Gly Ile Leu Asn Leu Ile Pro Ser Thr Arg 
                85                  90                  95      


Asn Thr His Gly Leu Ile Lys Ala Ile Met His Leu Leu Gln Met Gln 
            100                 105                 110         


Ala Leu Lys Glu Gly Gln Gly Gly Glu Lys Asn Ile Gln Ser Ile Tyr 
        115                 120                 125             


Thr Ile Arg Asn His Pro His Pro Leu Ile Thr Val Leu Glu His Arg 
    130                 135                 140                 


Pro Asp Cys Trp Pro Val Phe Leu Gln Gln Leu Thr Ala Phe Phe Gln 
145                 150                 155                 160 


Gln Cys Pro Glu Arg Leu Glu Val Ser Cys Ile Gln Ile Met Ala Pro 
                165                 170                 175     


Phe Leu Trp Tyr Leu Tyr Cys Glu Pro Ser Gln Leu Gln Glu Tyr Ala 
            180                 185                 190         


Lys Leu Arg Leu Ala Leu Leu Lys Val Leu Leu Gln Pro Gln Val Leu 
        195                 200                 205             


Cys Asp Lys Asp Gln Pro Ser Ile Leu Glu Gln Gln Ile Leu Gln Leu 
    210                 215                 220                 


Cys Cys Asp Ile Val Pro Cys Leu Gln Val Lys Asp Leu Ile Gln Thr 
225                 230                 235                 240 


Thr Glu Ala Met Met Phe Ile Glu Glu Val Cys Leu Ser Leu Leu Arg 
                245                 250                 255     


His Pro Val Phe Trp Lys Ile Gln Leu Thr Gln Met Ser Leu Gln Leu 
            260                 265                 270         


Leu Cys Val Ser Glu Val Ser Leu Lys Ile Thr Gly Glu Cys Ser Ser 
        275                 280                 285             


Ser Ile His Leu Leu Glu His Ser Val Glu Leu Leu Lys Glu Asp Phe 
    290                 295                 300                 


Pro Val Glu Leu Val Ile Ile Gly Ile Ala Leu Leu Leu Leu Gln Thr 
305                 310                 315                 320 


Pro Ala Ser Gln Gln Lys Pro Ile Leu Asn Leu Ala Leu Lys Leu Leu 
                325                 330                 335     


Ser Val Thr Glu Asp Gln Lys Ile Pro Lys Ser Ser Leu Leu Leu Val 
            340                 345                 350         


Met Pro Ile Leu Gln Ile Leu Ser Ser Thr Ala Leu Glu Asp Cys Ile 
        355                 360                 365             


Ser Val Asp Glu Glu Gly Pro Ser Arg Gln Gln Leu Ala Leu Asn Leu 
    370                 375                 380                 


Leu Glu Met Ile Gln Gln Glu Cys Tyr Arg Asp Asp His Gln Lys Leu 
385                 390                 395                 400 


Ser Tyr Lys Leu Val Cys Pro Val Thr Ser Met Tyr Gly Thr Ile Phe 
                405                 410                 415     


Thr Ala Trp Arg Ile Leu Glu Val Met Thr Asp Ser Ser Ala Ala Ser 
            420                 425                 430         


Asp Trp Leu Ala Ser Val Glu Ser Leu Leu Pro Ile Thr Ala Val Ile 
        435                 440                 445             


Pro Ala Pro Ala Phe Leu Leu Leu Ala His Leu Leu Val Glu Asp Lys 
    450                 455                 460                 


Gly Gln Asn Leu His Gln Ile Leu Lys Val Thr Thr Glu Leu Ala Gln 
465                 470                 475                 480 


Ala Asp Ser Ser Gln Val Pro Asn Leu Ile Pro Val Leu Met Phe Lys 
                485                 490                 495     


Leu Gly Arg Pro Leu Glu Pro Ile Leu Tyr Asn Asp Ile Leu Tyr Thr 
            500                 505                 510         


Leu Pro Lys Leu Gly Val His Lys Val Cys Ile Gly Gln Ile Leu Arg 
        515                 520                 525             


Ile Ile Gln Leu Leu Gly Thr Thr Pro Arg Leu Arg Ala Val Thr Leu 
    530                 535                 540                 


Arg Leu Leu Thr Ser Leu Trp Glu Lys Gln Asp Arg Val Tyr Pro Glu 
545                 550                 555                 560 


Leu Gln Arg Phe Met Ala Val Ser Asp Val Pro Ser Leu Ser Val Gly 
                565                 570                 575     


Lys Glu Val Gln Trp Glu Lys Leu Ile Ala Lys Ala Ala Ser Ile Arg 
            580                 585                 590         


Asp Ile Cys Lys Gln Arg Pro Tyr Gln His Gly Ala Asp Met Leu Ala 
        595                 600                 605             


Ala Ile Ser Gln Val Leu Asn Glu Cys Thr Lys Pro Asp Gln Ala Thr 
    610                 615                 620                 


Pro Ala Ala Leu Val Leu Gln Gly Leu His Ala Leu Cys Gln Ala Glu 
625                 630                 635                 640 


Val Val Cys Ile Arg Ser Thr Trp Asn Ala Leu Ser Pro Lys Leu Ser 
                645                 650                 655     


Cys Asp Thr Arg Pro Leu Ile Leu Lys Thr Leu Ser Glu Leu Phe Ser 
            660                 665                 670         


Leu Val Pro Ser Leu Thr Val Asn Thr Thr Glu Tyr Glu Asn Phe Lys 
        675                 680                 685             


Val Gln Val Leu Ser Phe Leu Trp Thr His Thr Gln Asn Lys Asp Pro 
    690                 695                 700                 


Ile Val Ala Asn Ala Ala Tyr Arg Ser Leu Ala Asn Phe Ser Ala Gly 
705                 710                 715                 720 


Glu His Thr Ile Leu His Leu Pro Glu Lys Ile Arg Pro Glu Ile Pro 
                725                 730                 735     


Ile Pro Glu Glu Leu Asp Asp Asp Glu Asp Val Glu Asp Val Asp Leu 
            740                 745                 750         


Ser Val Pro Gly Ser Cys Tyr Leu Lys Leu Leu Ser Leu Thr Pro Pro 
        755                 760                 765             


Leu Val Leu Pro Ala Leu Glu Glu Phe Phe Thr Ser Leu Val Lys Gln 
    770                 775                 780                 


Glu Met Val Asn Met Pro Arg Gly Ile Tyr His Ser Ala Leu Lys Gly 
785                 790                 795                 800 


Gly Ala Arg Ser Asp Gln Gly Lys Thr Val Ala Gly Ile Pro Asn Phe 
                805                 810                 815     


Ile Leu Lys Met Tyr Glu Thr Asn Lys Gln Pro Gly Leu Lys Pro Gly 
            820                 825                 830         


Leu Ala Gly Gly Met Leu Phe Cys Tyr Asp Val Ser Met Tyr Gln Ser 
        835                 840                 845             


Lys Asp Gly Lys Pro Leu Asn Arg Leu Met Ala Ser Arg Gly Arg Ser 
    850                 855                 860                 


Phe Lys Gln Thr Ser Leu Ala Leu Val His Glu Val His Ile Gln Leu 
865                 870                 875                 880 


Ser Glu Trp His Arg Ala Ile Phe Leu Pro Gln Ala Trp Leu Ala Tyr 
                885                 890                 895     


Met Asn Arg Ala Tyr His Ala Ile Leu Gln Gly Arg Leu Gly Glu Leu 
            900                 905                 910         


Glu Leu Gln Leu Lys His Gly Lys Glu Glu Pro Glu Glu Val Gln Tyr 
        915                 920                 925             


Lys Lys Ser Thr Ala Trp Leu Trp Val Arg Asp Met Leu Thr Asp Glu 
    930                 935                 940                 


Ile Thr Lys Ala Ala Ala Lys Glu Ser Pro Val Val Lys Gly Asn Ala 
945                 950                 955                 960 


Leu Leu Ala Leu Ser Ser Leu Ala Val Val Val Ser Arg His Glu Ala 
                965                 970                 975     


Ser Leu Ser Ser Asp Ser Asp Gly Leu Leu Glu Val Gln Pro Asn Phe 
            980                 985                 990         


Leu Ser Met Lys Glu Trp Val Ser  Met Val Leu Asp Thr  Leu Leu Val 
        995                 1000                 1005             


Ile Val  Asp Ser His Tyr Gln  Pro Arg Gly Gln Leu  Leu Ser Trp 
    1010                 1015                 1020             


Phe Tyr  Tyr Lys Ser Tyr Ser  Gly Glu Asn Thr Ala  Ser Ala Ile 
    1025                 1030                 1035             


Ala Arg  Ser Ala Ala Ala Thr  Ala Leu Ser Leu Leu  Val Pro Val 
    1040                 1045                 1050             


Phe Ile  Ile Ser Cys Lys Glu  Lys Val Glu Glu Ile  Leu Asn Met 
    1055                 1060                 1065             


Leu Thr  Ala Arg Leu Pro Gly  Lys Pro Ser Ala Asp  Glu Ser Gln 
    1070                 1075                 1080             


Ala Val  Gln Ile His Met Gly  Leu Ala Leu Gly Met  Phe Leu Ser 
    1085                 1090                 1095             


Arg Leu  Cys Glu Glu Lys Leu  Ser Asp Ile Ser Gly  Gln Glu Met 
    1100                 1105                 1110             


Asn Leu  Leu Leu Met Lys Ser  Leu Asp Ala Leu Glu  Asn Cys Cys 
    1115                 1120                 1125             


Phe Asp  Thr Ser Leu Glu Tyr  Asn Thr Gly Cys Ile  Leu Gly Val 
    1130                 1135                 1140             


Gly Leu  Val Leu Ser Leu Met  Ser His Ser Ser Gln  Met Gln Ser 
    1145                 1150                 1155             


Arg Val  His Val Ala Ala Leu  Leu Arg Lys Leu Ser  Ala His Val 
    1160                 1165                 1170             


Asp Asp  Ser Gly Ser Gln Ser  Arg Thr Phe Gln Glu  Val Leu Ala 
    1175                 1180                 1185             


Tyr Thr  Leu Ser Cys Val Cys  Thr Ser Ala Phe Ser  Ala Gly Ile 
    1190                 1195                 1200             


Ile Glu  Ala Thr Glu Ala Glu  Asp Val Met Asn Lys  Leu Arg Leu 
    1205                 1210                 1215             


Leu Val  Glu Asn Ser Gln Gln  Thr Ser Gly Phe Ala  Leu Ala Leu 
    1220                 1225                 1230             


Gly Asn  Ile Val His Gly Leu  Ser Val Cys Gly His  Gly Lys Ala 
    1235                 1240                 1245             


Glu Asp  Leu Gly Ser Lys Leu  Leu Pro Ala Trp Ile  Arg Ile Val 
    1250                 1255                 1260             


Leu Thr  Glu Gly Thr Pro Thr  Met Leu Cys Leu Ala  Ala Leu His 
    1265                 1270                 1275             


Gly Met  Val Ala Leu Val Gly  Ser Glu Gly Asp Val  Met Gln Leu 
    1280                 1285                 1290             


Lys Ser  Glu Ala Ile Gln Thr  Ser His Phe Gln Gly  Arg Leu Asn 
    1295                 1300                 1305             


Glu Val  Ile Arg Thr Leu Thr  Gln Val Ile Ser Val  Ser Gly Val 
    1310                 1315                 1320             


Ile Gly  Leu Gln Ser Asn Ala  Val Trp Leu Leu Gly  His Leu His 
    1325                 1330                 1335             


Leu Ser  Thr Leu Ser Ser Ser  Gln Ser Arg Ala Ser  Val Pro Thr 
    1340                 1345                 1350             


Asp Tyr  Ser Tyr Leu Pro Glu  Ser Ser Phe Ile Gly  Ala Ala Ile 
    1355                 1360                 1365             


Gly Phe  Phe Ile Thr Gly Gly  Lys Lys Gly Pro Glu  Ser Val Pro 
    1370                 1375                 1380             


Pro Ser  Leu Leu Lys Val Val  Met Lys Pro Ile Ala  Thr Val Gly 
    1385                 1390                 1395             


Glu Ser  Tyr Gln Tyr Pro Pro  Val Asn Trp Ala Ala  Leu Leu Ser 
    1400                 1405                 1410             


Pro Leu  Met Arg Leu Asn Phe  Gly Glu Glu Ile Gln  Gln Leu Cys 
    1415                 1420                 1425             


Leu Glu  Ile Met Val Thr Gln  Ala Gln Ser Ser Gln  Asn Ala Ala 
    1430                 1435                 1440             


Ala Leu  Leu Gly Leu Trp Val  Thr Pro Pro Leu Ile  His Ser Leu 
    1445                 1450                 1455             


Ser Leu  Asn Thr Lys Arg Tyr  Leu Leu Ile Ser Ala  Pro Leu Trp 
    1460                 1465                 1470             


Ile Lys  His Ile Ser Asp Glu  Gln Ile Leu Gly Phe  Val Glu Asn 
    1475                 1480                 1485             


Leu Met  Val Ala Val Phe Lys  Ala Ala Ser Pro Leu  Gly Ser Pro 
    1490                 1495                 1500             


Glu Leu  Cys Pro Ser Ala Leu  His Gly Leu Ser Gln  Ala Met Lys 
    1505                 1510                 1515             


Leu Pro  Ser Pro Ala His His  Leu Trp Ser Leu Leu  Ser Glu Ala 
    1520                 1525                 1530             


Thr Gly  Lys Ile Phe Asp Leu  Leu Pro Asn Lys Ile  Arg Arg Lys 
    1535                 1540                 1545             


Asp Leu  Glu Leu Tyr Ile Ser  Ile Ala Lys Cys Leu  Leu Glu Met 
    1550                 1555                 1560             


Thr Asp  Asp Asp Ala Asn Arg  Ile Ala Gln Val Thr  Lys Ser Asn 
    1565                 1570                 1575             


Ile Glu  Lys Ala Ala Phe Val  Lys Leu Tyr Leu Val  Ser Gln Gly 
    1580                 1585                 1590             


Arg Phe  Pro Leu Val Asn Leu  Thr Asp Met Leu Ser  Val Ala Val 
    1595                 1600                 1605             


Gln His  Arg Glu Lys Glu Val  Leu Ala Trp Met Ile  Leu His Ser 
    1610                 1615                 1620             


Leu Tyr  Gln Ala Arg Ile Val  Ser His Ala Asn Thr  Gly Val Leu 
    1625                 1630                 1635             


Lys Arg  Met Glu Trp Leu Leu  Glu Leu Met Gly Tyr  Ile Arg Asn 
    1640                 1645                 1650             


Val Ala  Tyr Gln Ser Thr Ser  Phe His Asn Thr Ala  Leu Asp Lys 
    1655                 1660                 1665             


Ala Leu  Asp Phe Phe Leu Leu  Ile Phe Ala Thr Ala  Val Val Ala 
    1670                 1675                 1680             


Trp Ala  Asp His Thr Ala Pro  Leu Leu Leu Gly Leu  Ser Ala Ser 
    1685                 1690                 1695             


Trp Leu  Pro Trp His Gln Glu  Asn Gly Pro Ala Gly  Pro Val Pro 
    1700                 1705                 1710             


Ser Phe  Leu Gly Arg Ser Pro  Met His Arg Val Thr  Leu Gln Glu 
    1715                 1720                 1725             


Val Leu  Thr Leu Leu Pro Asn  Ser Met Ala Leu Leu  Leu Gln Lys 
    1730                 1735                 1740             


Glu Pro  Trp Lys Glu Gln Thr  Gln Lys Phe Ile Asp  Trp Leu Phe 
    1745                 1750                 1755             


Ser Ile  Met Glu Ser Pro Lys  Glu Ala Leu Ser Ala  Gln Ser Arg 
    1760                 1765                 1770             


Asp Leu  Leu Lys Ala Thr Leu  Leu Ser Leu Arg Val  Leu Pro Glu 
    1775                 1780                 1785             


Phe Lys  Lys Lys Ala Val Trp  Thr Arg Ala Tyr Gly  Trp 
    1790                 1795                 1800     


<210>  5512
<211>  181
<212>  PRT
<213>  Homo Sapiens

<400>  5512

Met Leu Pro Ala Ala Thr Glu Gly Gln Lys Asp Met Val Trp Lys Trp 
1               5                   10                  15      


Met Pro Leu Leu Leu Leu Leu Val Cys Val Ala Thr Met Cys Ser Ala 
            20                  25                  30          


Gln Asp Arg Thr Asp Leu Leu Asn Val Cys Met Asp Ala Lys His His 
        35                  40                  45              


Lys Thr Lys Pro Gly Pro Glu Asp Lys Leu His Asp Gln Cys Ser Pro 
    50                  55                  60                  


Trp Lys Lys Asn Ala Cys Cys Thr Ala Ser Thr Ser Gln Glu Leu His 
65                  70                  75                  80  


Lys Asp Thr Ser Arg Leu Tyr Asn Phe Asn Trp Asp His Cys Gly Lys 
                85                  90                  95      


Met Glu Pro Ala Cys Lys Arg His Phe Ile Gln Asp Thr Cys Leu Tyr 
            100                 105                 110         


Glu Cys Ser Pro Asn Leu Gly Pro Trp Ile Gln Gln Val Asn Gln Ser 
        115                 120                 125             


Trp Arg Lys Glu Arg Phe Leu Asp Val Pro Leu Cys Lys Glu Asp Cys 
    130                 135                 140                 


Gln Arg Trp Trp Glu Asp Cys His Thr Ser His Thr Cys Lys Ser Asn 
145                 150                 155                 160 


Trp His Arg Gly Trp Asp Trp Thr Ser Gly Val Asn Lys Cys Pro Ala 
                165                 170                 175     


Gly Ala Leu Cys Arg 
            180     


<210>  5513
<211>  198
<212>  PRT
<213>  Homo Sapiens

<400>  5513

Met Leu Pro Ala Ala Thr Glu Leu Arg Leu Gln Gly Gln Lys Asp Met 
1               5                   10                  15      


Val Trp Lys Trp Met Pro Leu Leu Leu Leu Leu Val Cys Val Ala Thr 
            20                  25                  30          


Met Cys Ser Ala Gln Asp Arg Thr Asp Leu Leu Asn Val Cys Met Asp 
        35                  40                  45              


Ala Lys His His Lys Thr Lys Pro Gly Pro Glu Asp Lys Leu His Asp 
    50                  55                  60                  


Gln Cys Ser Pro Trp Lys Lys Asn Ala Cys Cys Thr Ala Ser Thr Ser 
65                  70                  75                  80  


Gln Glu Leu His Lys Asp Thr Ser Arg Leu Tyr Asn Phe Asn Trp Asp 
                85                  90                  95      


His Cys Gly Lys Met Glu Pro Ala Cys Lys Arg His Phe Ile Gln Asp 
            100                 105                 110         


Thr Cys Leu Tyr Glu Cys Ser Pro Asn Leu Gly Pro Trp Ile Gln Gln 
        115                 120                 125             


Val Asn Gln Ser Trp Arg Lys Glu Arg Phe Leu Asp Val Pro Leu Cys 
    130                 135                 140                 


Lys Glu Asp Cys Gln Arg Trp Trp Glu Asp Cys His Thr Ser His Thr 
145                 150                 155                 160 


Cys Lys Ser Asn Trp His Arg Gly Trp Asp Trp Thr Ser Gly Val Asn 
                165                 170                 175     


Lys Cys Pro Ala Gly Ala Leu Cys Arg Thr Phe Glu Ser Tyr Phe Pro 
            180                 185                 190         


Thr Pro Ala Ala Leu Cys 
        195             


<210>  5514
<211>  214
<212>  PRT
<213>  Homo Sapiens

<400>  5514

Met Leu Pro Ala Ala Thr Glu Val Gln Cys Ser Pro Trp Lys Lys Asn 
1               5                   10                  15      


Ala Cys Cys Thr Ala Ser Thr Ser Gln Glu Leu His Lys Asp Thr Ser 
            20                  25                  30          


Arg Leu Tyr Asn Phe Asn Trp Asp His Cys Gly Lys Met Glu Pro Ala 
        35                  40                  45              


Cys Lys Arg His Phe Ile Gln Asp Thr Cys Leu Tyr Glu Cys Ser Pro 
    50                  55                  60                  


Asn Leu Gly Pro Trp Ile Gln Gln Val Asn Gln Ser Trp Arg Lys Glu 
65                  70                  75                  80  


Arg Phe Leu Asp Val Pro Leu Cys Lys Glu Asp Cys Gln Arg Trp Trp 
                85                  90                  95      


Glu Asp Cys His Thr Ser His Thr Cys Lys Ser Asn Trp His Arg Gly 
            100                 105                 110         


Trp Asp Trp Thr Ser Gly Val Asn Lys Cys Pro Ala Gly Ala Leu Cys 
        115                 120                 125             


Arg Thr Phe Glu Ser Tyr Phe Pro Thr Pro Ala Ala Leu Cys Glu Gly 
    130                 135                 140                 


Leu Trp Ser His Ser Tyr Lys Val Ser Asn Tyr Ser Arg Gly Ser Gly 
145                 150                 155                 160 


Arg Cys Ile Gln Met Trp Phe Asp Ser Ala Gln Gly Asn Pro Asn Glu 
                165                 170                 175     


Glu Val Ala Arg Phe Tyr Ala Ala Ala Met His Val Asn Ala Gly Glu 
            180                 185                 190         


Met Leu His Gly Thr Gly Gly Leu Leu Leu Ser Leu Ala Leu Met Leu 
        195                 200                 205             


Gln Leu Trp Leu Leu Gly 
    210                 


<210>  5515
<211>  210
<212>  PRT
<213>  Homo Sapiens

<400>  5515

Met Leu Pro Ala Ala Thr Glu Val Gln Gly Gln Lys Asp Met Val Trp 
1               5                   10                  15      


Lys Trp Met Pro Leu Leu Leu Leu Leu Val Cys Val Ala Thr Met Cys 
            20                  25                  30          


Ser Ala Gln Asp Arg Thr Asp Leu Leu Asn Val Cys Met Asp Ala Lys 
        35                  40                  45              


His His Lys Thr Lys Pro Gly Pro Glu Asp Lys Leu His Asp Gln Cys 
    50                  55                  60                  


Ser Pro Trp Lys Lys Asn Ala Cys Cys Thr Ala Ser Thr Ser Gln Glu 
65                  70                  75                  80  


Leu His Lys Asp Thr Ser Arg Leu Tyr Asn Phe Asn Trp Asp His Cys 
                85                  90                  95      


Gly Lys Met Glu Pro Ala Cys Lys Arg His Phe Ile Gln Asp Thr Cys 
            100                 105                 110         


Leu Tyr Glu Cys Ser Pro Asn Leu Gly Pro Trp Ile Gln Gln Val Asn 
        115                 120                 125             


Gln Ser Trp Arg Lys Glu Arg Phe Leu Asp Val Pro Leu Cys Lys Glu 
    130                 135                 140                 


Asp Cys Gln Arg Trp Trp Glu Asp Cys His Thr Ser His Thr Cys Lys 
145                 150                 155                 160 


Ser Asn Trp His Arg Gly Trp Asp Trp Thr Ser Gly Val Asn Lys Cys 
                165                 170                 175     


Pro Ala Gly Ala Leu Cys Arg Thr Phe Glu Ser Tyr Phe Pro Thr Pro 
            180                 185                 190         


Ala Ala Leu Cys Glu Gly Leu Trp Ser His Ser Tyr Lys Val Ser Asn 
        195                 200                 205             


Tyr Ser 
    210 


<210>  5516
<211>  148
<212>  PRT
<213>  Homo Sapiens

<400>  5516

Met Leu Pro Ala Ala Thr Glu Val Gln Lys Asp His Ala Gly Ser Cys 
1               5                   10                  15      


Gly Glu Gly Asn Leu Lys Gly Lys Lys Leu Glu Glu Gly Arg Leu Asp 
            20                  25                  30          


Thr Lys His Arg Ala Met Leu Arg Leu Gln Gly Gln Lys Asp Met Val 
        35                  40                  45              


Trp Lys Trp Met Pro Leu Leu Leu Leu Leu Val Cys Val Ala Thr Met 
    50                  55                  60                  


Cys Ser Ala Gln Asp Arg Thr Asp Leu Leu Asn Val Cys Met Asp Ala 
65                  70                  75                  80  


Lys His His Lys Thr Lys Pro Gly Pro Glu Asp Lys Leu His Asp Gln 
                85                  90                  95      


Cys Ser Pro Trp Lys Lys Asn Ala Cys Cys Thr Ala Ser Thr Ser Gln 
            100                 105                 110         


Glu Leu His Lys Asp Thr Ser Arg Leu Tyr Asn Phe Asn Trp Asp His 
        115                 120                 125             


Cys Gly Lys Met Glu Pro Ala Cys Lys Arg His Phe Ile Gln Asp Thr 
    130                 135                 140                 


Cys Leu Tyr Glu 
145             


<210>  5517
<211>  251
<212>  PRT
<213>  Homo Sapiens

<400>  5517

Met Leu Pro Ala Ala Thr Glu Val Gln Leu Arg Leu Gln Gly Gln Lys 
1               5                   10                  15      


Asp Met Val Trp Lys Trp Met Pro Leu Leu Leu Leu Leu Val Cys Val 
            20                  25                  30          


Ala Thr Met Cys Ser Ala Gln Asp Arg Thr Asp Leu Leu Asn Val Cys 
        35                  40                  45              


Met Asp Ala Lys His His Lys Thr Lys Pro Gly Pro Glu Asp Lys Leu 
    50                  55                  60                  


His Asp Gln Cys Ser Pro Trp Lys Lys Asn Ala Cys Cys Thr Ala Ser 
65                  70                  75                  80  


Thr Ser Gln Glu Leu His Lys Asp Thr Ser Arg Leu Tyr Asn Phe Asn 
                85                  90                  95      


Trp Asp His Cys Gly Lys Met Glu Pro Ala Cys Lys Arg His Phe Ile 
            100                 105                 110         


Gln Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn Leu Gly Pro Trp Ile 
        115                 120                 125             


Gln Gln Val Asn Gln Ser Trp Arg Lys Glu Arg Phe Leu Asp Val Pro 
    130                 135                 140                 


Leu Cys Lys Glu Asp Cys Gln Arg Trp Trp Glu Asp Cys His Thr Ser 
145                 150                 155                 160 


His Thr Cys Lys Ser Asn Trp His Arg Gly Trp Asp Trp Thr Ser Ala 
                165                 170                 175     


Ala Leu Cys Glu Gly Leu Trp Ser His Ser Tyr Lys Val Ser Asn Tyr 
            180                 185                 190         


Ser Arg Gly Ser Gly Arg Cys Ile Gln Met Trp Phe Asp Ser Ala Gln 
        195                 200                 205             


Gly Asn Pro Asn Glu Glu Val Ala Arg Phe Tyr Ala Ala Ala Met His 
    210                 215                 220                 


Val Asn Ala Gly Glu Met Leu His Gly Thr Gly Gly Leu Leu Leu Ser 
225                 230                 235                 240 


Leu Ala Leu Met Leu Gln Leu Trp Leu Leu Gly 
                245                 250     


<210>  5518
<211>  244
<212>  PRT
<213>  Homo Sapiens

<400>  5518

Met Leu Pro Ala Ala Thr Glu Val Gln Leu Arg Leu Gln Gly Gln Lys 
1               5                   10                  15      


Asp Met Val Trp Lys Trp Met Pro Leu Leu Leu Leu Leu Val Cys Val 
            20                  25                  30          


Ala Thr Met Cys Ser Ala Gln Asp Arg Thr Asp Leu Leu Asn Val Cys 
        35                  40                  45              


Met Asp Ala Lys His His Lys Thr Lys Pro Gly Pro Glu Asp Lys Leu 
    50                  55                  60                  


His Asp Gln Cys Ser Pro Trp Lys Lys Asn Ala Cys Cys Thr Ala Ser 
65                  70                  75                  80  


Thr Ser Gln Glu Leu His Lys Asp Thr Ser Arg Leu Tyr Asn Phe Asn 
                85                  90                  95      


Trp Asp His Cys Gly Lys Met Glu Pro Ala Cys Ser Ala Thr Ser Ser 
            100                 105                 110         


Arg Thr Pro Val Ser Met Ser Ala His Gln Pro Gly Ala Leu Asp Pro 
        115                 120                 125             


Ala Gly Ile Arg Ala Gly Ala Lys Asn Ala Ser Trp Met Cys Pro Tyr 
    130                 135                 140                 


Ala Lys Arg Thr Val Ser Ala Gly Gly Arg Ile Val Thr Pro Pro Thr 
145                 150                 155                 160 


Arg Ala Arg Ala Thr Gly Thr Glu Asp Gly Thr Gly Pro Gln Glu Leu 
                165                 170                 175     


Thr Ser Ala Gln Leu Gly Leu Ser Ala Ala Pro Leu Ser Pro Thr Ser 
            180                 185                 190         


Pro Leu Gln Leu Pro Phe Val Lys Ala Ser Gly Val Thr His Thr Arg 
        195                 200                 205             


Ser Ala Thr Thr Ala Glu Gly Ala Ala Ala Ala Ser Arg Cys Gly Leu 
    210                 215                 220                 


Ile Gln Pro Arg Ala Thr Pro Thr Arg Lys Trp Arg Gly Ser Met Leu 
225                 230                 235                 240 


Gln Pro Cys Met 
                


<210>  5519
<211>  169
<212>  PRT
<213>  Homo Sapiens

<400>  5519

Met Val Trp Lys Trp Met Pro Leu Leu Leu Leu Leu Val Cys Val Ala 
1               5                   10                  15      


Thr Met Cys Ser Ala Gln Asp Arg Thr Asp Leu Leu Asn Val Cys Met 
            20                  25                  30          


Asp Ala Lys His His Lys Thr Lys Pro Gly Pro Glu Asp Lys Leu His 
        35                  40                  45              


Asp Gln Cys Ser Pro Trp Lys Lys Asn Ala Cys Cys Thr Ala Ser Thr 
    50                  55                  60                  


Ser Gln Glu Leu His Lys Asp Thr Ser Arg Leu Tyr Asn Phe Asn Trp 
65                  70                  75                  80  


Asp His Cys Gly Lys Met Glu Pro Ala Cys Lys Arg His Phe Ile Gln 
                85                  90                  95      


Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn Leu Gly Pro Trp Ile Gln 
            100                 105                 110         


Gln Val Asn Gln Ser Trp Arg Lys Glu Arg Phe Leu Asp Val Pro Leu 
        115                 120                 125             


Cys Lys Glu Asp Cys Gln Arg Trp Trp Glu Asp Cys His Thr Ser His 
    130                 135                 140                 


Thr Cys Lys Ser Asn Trp His Arg Gly Trp Asp Trp Thr Ser Ala Ala 
145                 150                 155                 160 


Leu Cys Glu Gly Leu Trp Ser His Ser 
                165                 


<210>  5520
<211>  171
<212>  PRT
<213>  Homo Sapiens

<400>  5520

Met Val Trp Lys Trp Met Pro Leu Leu Leu Leu Leu Val Cys Val Ala 
1               5                   10                  15      


Thr Met Cys Ser Ala Gln Asp Arg Thr Asp Leu Leu Asn Val Cys Met 
            20                  25                  30          


Asp Ala Lys His His Lys Thr Lys Pro Gly Pro Glu Asp Lys Leu His 
        35                  40                  45              


Asp Gln Cys Ser Pro Trp Lys Lys Asn Ala Cys Cys Thr Ala Ser Thr 
    50                  55                  60                  


Ser Gln Glu Leu His Lys Asp Thr Ser Arg Leu Tyr Asn Phe Asn Trp 
65                  70                  75                  80  


Asp His Cys Gly Lys Met Glu Pro Ala Cys Lys Arg His Phe Ile Gln 
                85                  90                  95      


Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn Leu Gly Pro Trp Ile Gln 
            100                 105                 110         


Gln Val Asn Gln Ser Trp Arg Lys Glu Arg Phe Leu Asp Val Pro Leu 
        115                 120                 125             


Cys Lys Glu Asp Cys Gln Arg Trp Trp Glu Asp Cys His Thr Ser His 
    130                 135                 140                 


Thr Cys Lys Ser Asn Trp His Arg Gly Trp Asp Trp Thr Ser Gly Val 
145                 150                 155                 160 


Asn Lys Cys Pro Ala Gly Ala Leu Cys Arg Thr 
                165                 170     


<210>  5521
<211>  255
<212>  PRT
<213>  Homo Sapiens

<400>  5521

Met Val Trp Lys Trp Met Pro Leu Leu Leu Leu Leu Val Cys Val Ala 
1               5                   10                  15      


Thr Met Cys Ser Ala Gln Asp Arg Thr Asp Leu Leu Asn Val Cys Met 
            20                  25                  30          


Asp Ala Lys His His Lys Thr Lys Pro Gly Pro Glu Asp Lys Leu His 
        35                  40                  45              


Asp Gln Cys Ser Pro Trp Lys Lys Asn Ala Cys Cys Thr Ala Ser Thr 
    50                  55                  60                  


Ser Gln Glu Leu His Lys Asp Thr Ser Arg Leu Tyr Asn Phe Asn Trp 
65                  70                  75                  80  


Asp His Cys Gly Lys Met Glu Pro Ala Cys Lys Arg His Phe Ile Gln 
                85                  90                  95      


Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn Leu Gly Pro Trp Ile Gln 
            100                 105                 110         


Gln Val Asn Gln Ser Trp Arg Lys Glu Arg Phe Leu Asp Val Pro Leu 
        115                 120                 125             


Cys Lys Glu Asp Cys Gln Arg Trp Trp Glu Asp Cys His Thr Ser His 
    130                 135                 140                 


Thr Cys Lys Ser Asn Trp His Arg Gly Trp Asp Trp Thr Ser Gly Val 
145                 150                 155                 160 


Asn Lys Cys Pro Ala Gly Ala Leu Cys Arg Thr Phe Glu Ser Tyr Phe 
                165                 170                 175     


Pro Thr Pro Ala Ala Leu Cys Glu Gly Leu Trp Ser His Ser Tyr Lys 
            180                 185                 190         


Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg Cys Ile Gln Met Trp Phe 
        195                 200                 205             


Asp Ser Ala Gln Gly Asn Pro Asn Glu Glu Val Ala Arg Phe Tyr Ala 
    210                 215                 220                 


Ala Ala Met His Val Asn Ala Gly Glu Met Leu His Gly Thr Gly Gly 
225                 230                 235                 240 


Leu Leu Leu Ser Leu Ala Leu Met Leu Gln Leu Trp Leu Leu Gly 
                245                 250                 255 


<210>  5522
<211>  74
<212>  PRT
<213>  Homo Sapiens

<400>  5522

Met Ala Trp Gln Met Met Gln Leu Leu Leu Leu Ala Leu Val Thr Ala 
1               5                   10                  15      


Ala Gly Ser Ala Gln Pro Arg Ser Ala Arg Ala Arg Thr Asp Leu Leu 
            20                  25                  30          


Asn Val Cys Met Asn Ala Lys His His Lys Thr Gln Pro Ser Pro Glu 
        35                  40                  45              


Asp Glu Leu Tyr Gly Gln Cys Ser Pro Trp Lys Lys Asn Ala Cys Cys 
    50                  55                  60                  


Thr Ala Ser Thr Ser Gln Glu Leu His Lys 
65                  70                  


<210>  5523
<211>  104
<212>  PRT
<213>  Homo Sapiens

<400>  5523

Met Ala Trp Gln Met Met Gln Leu Leu Leu Leu Ala Leu Val Thr Ala 
1               5                   10                  15      


Ala Gly Ser Ala Gln Pro Arg Ser Ala Arg Ala Arg Thr Asp Leu Leu 
            20                  25                  30          


Asn Val Cys Met Asn Ala Lys His His Lys Thr Gln Pro Ser Pro Glu 
        35                  40                  45              


Asp Glu Leu Tyr Gly Gln Cys Ser Pro Trp Lys Lys Asn Ala Cys Cys 
    50                  55                  60                  


Thr Ala Ser Thr Ser Gln Glu Leu His Lys Asp Thr Ser Arg Leu Tyr 
65                  70                  75                  80  


Asn Phe Asn Trp Asp His Cys Gly Lys Met Glu Pro Thr Cys Lys Arg 
                85                  90                  95      


His Phe Ile Gln Asp Ser Cys Leu 
            100                 


<210>  5524
<211>  178
<212>  PRT
<213>  Homo Sapiens

<400>  5524

Met Asp Met Ala Trp Gln Met Met Gln Leu Leu Leu Leu Ala Leu Val 
1               5                   10                  15      


Thr Ala Ala Gly Ser Ala Gln Pro Arg Ser Ala Arg Ala Arg Thr Asp 
            20                  25                  30          


Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys Thr Gln Pro Ser 
        35                  40                  45              


Pro Glu Asp Glu Leu Tyr Gly Gln Cys Ser Pro Trp Lys Lys Asn Ala 
    50                  55                  60                  


Cys Cys Thr Ala Ser Thr Ser Gln Glu Leu His Lys Asp Thr Ser Arg 
65                  70                  75                  80  


Leu Tyr Asn Phe Asn Trp Asp His Cys Gly Lys Met Glu Pro Thr Cys 
                85                  90                  95      


Lys Arg His Phe Ile Gln Asp Ser Cys Leu Tyr Glu Cys Ser Pro Asn 
            100                 105                 110         


Leu Gly Pro Trp Ile Arg Gln Val Asn Gln Ser Trp Arg Lys Glu Arg 
        115                 120                 125             


Ile Leu Asn Val Pro Leu Cys Lys Glu Asp Cys Glu Arg Trp Trp Glu 
    130                 135                 140                 


Asp Cys Arg Thr Ser Tyr Thr Cys Lys Ser Asn Trp His Lys Gly Trp 
145                 150                 155                 160 


Asn Trp Thr Ser Gly Ile Asn Glu Cys Pro Ala Gly Ala Leu Cys Ser 
                165                 170                 175     


Thr Phe 
        


<210>  5525
<211>  245
<212>  PRT
<213>  Homo Sapiens

<400>  5525

Met Asp Met Ala Trp Gln Met Met Gln Leu Leu Leu Leu Ala Leu Val 
1               5                   10                  15      


Thr Ala Ala Gly Ser Ala Gln Pro Arg Ser Ala Arg Ala Arg Thr Asp 
            20                  25                  30          


Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys Thr Gln Pro Ser 
        35                  40                  45              


Pro Glu Asp Glu Leu Tyr Gly Gln Cys Ser Pro Trp Lys Lys Asn Ala 
    50                  55                  60                  


Cys Cys Thr Ala Ser Thr Ser Gln Glu Leu His Lys Asp Thr Ser Arg 
65                  70                  75                  80  


Leu Tyr Asn Phe Asn Trp Asp His Cys Gly Lys Met Glu Pro Thr Cys 
                85                  90                  95      


Lys Arg His Phe Ile Gln Asp Ser Cys Leu Tyr Glu Cys Ser Pro Asn 
            100                 105                 110         


Leu Gly Pro Trp Ile Arg Gln Val Asn Gln Ser Trp Arg Lys Glu Arg 
        115                 120                 125             


Ile Leu Asn Val Pro Leu Cys Lys Glu Asp Cys Glu Arg Trp Trp Glu 
    130                 135                 140                 


Asp Cys Arg Thr Ser Tyr Thr Cys Lys Ser Asn Trp His Lys Gly Trp 
145                 150                 155                 160 


Asn Trp Thr Ser Gly Ile Asn Glu Cys Pro Ala Gly Ala Leu Cys Ser 
                165                 170                 175     


Thr Phe Glu Ser Tyr Phe Pro Thr Pro Ala Ala Leu Cys Glu Gly Leu 
            180                 185                 190         


Trp Ser His Ser Phe Lys Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg 
        195                 200                 205             


Cys Ile Gln Met Trp Phe Asp Ser Ala Gln Gly Asn Pro Asn Glu Glu 
    210                 215                 220                 


Val Ala Lys Phe Tyr Ala Ala Ala Met Asn Ala Gly Ala Pro Ser Arg 
225                 230                 235                 240 


Gly Ile Ile Asp Ser 
                245 


<210>  5526
<211>  172
<212>  PRT
<213>  Homo Sapiens

<400>  5526

Met Asp Met Ala Trp Gln Met Met Gln Leu Leu Leu Leu Ala Leu Val 
1               5                   10                  15      


Thr Ala Ala Gly Ser Ala Gln Pro Arg Ser Ala Arg Ala Arg Thr Asp 
            20                  25                  30          


Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys Thr Gln Pro Ser 
        35                  40                  45              


Pro Glu Asp Glu Leu Tyr Gly Gln Val Gly Ala Pro Gln Gly Pro Ser 
    50                  55                  60                  


Pro Gly Ser Val Pro Leu Asp Asp Leu Pro Gly Ala Glu Glu Pro Glu 
65                  70                  75                  80  


Tyr Gly Gly Asp Gly Cys Gly Gly Glu Arg Leu Ser Pro Val Ser Ser 
                85                  90                  95      


Pro Pro Ser Ala Val Pro Gly Arg Arg Met Pro Ala Ala Arg Pro Ala 
            100                 105                 110         


Pro Ala Arg Ser Cys Thr Arg Thr Pro Pro Ala Cys Thr Thr Leu Thr 
        115                 120                 125             


Gly Ile Thr Val Val Arg Trp Asn Pro Pro Ala Ser Ala Thr Leu Ser 
    130                 135                 140                 


Arg Thr Ala Val Ser Met Ser Ala His Pro Thr Trp Gly Pro Gly Ser 
145                 150                 155                 160 


Gly Arg Ser Thr Arg Ala Gly Ala Lys Ser Ala Phe 
                165                 170         


<210>  5527
<211>  86
<212>  PRT
<213>  Homo Sapiens

<400>  5527

Met Gly Leu Ser Ala Ala Ala Pro Leu Trp Gly Pro Pro Gly Leu Leu 
1               5                   10                  15      


Leu Ala Ile Ala Leu His Pro Ala Leu Ser Val Pro Pro Arg Arg Asp 
            20                  25                  30          


Tyr Cys Val Leu Gly Ala Gly Pro Ala Gly Leu Gln Met Ala Tyr Phe 
        35                  40                  45              


Leu Gln Arg Ala Gly Arg Asp Tyr Ala Val Phe Glu Arg Ala Pro Arg 
    50                  55                  60                  


Pro Gly Ser Phe Phe Thr Arg Tyr Pro Arg His Arg Lys Leu Ile Ser 
65                  70                  75                  80  


Ile Asn Lys Arg Tyr Thr 
                85      


<210>  5528
<211>  684
<212>  PRT
<213>  Homo Sapiens

<400>  5528

Met Gly Leu Ser Ala Ala Ala Pro Leu Trp Gly Pro Pro Gly Leu Leu 
1               5                   10                  15      


Leu Ala Ile Ala Leu His Pro Ala Leu Ser Val Pro Pro Arg Arg Asp 
            20                  25                  30          


Tyr Cys Val Leu Gly Ala Gly Pro Ala Gly Leu Gln Met Ala Tyr Phe 
        35                  40                  45              


Leu Gln Arg Ala Gly Arg Asp Tyr Ala Val Phe Glu Arg Ala Pro Arg 
    50                  55                  60                  


Pro Gly Ser Phe Phe Thr Arg Tyr Pro Arg His Arg Lys Leu Ile Ser 
65                  70                  75                  80  


Ile Asn Lys Arg Tyr Thr Gly Lys Ala Asn Ala Glu Phe Asn Leu Arg 
                85                  90                  95      


His Asp Trp Asn Ser Leu Leu Ser His Asp Pro Arg Leu Leu Phe Arg 
            100                 105                 110         


His Tyr Ser Arg Ala Tyr Phe Pro Asp Ala Arg Asp Met Val Arg Tyr 
        115                 120                 125             


Leu Gly Asp Phe Ala Asp Thr Leu Gly Leu Arg Val Gln Tyr Asn Thr 
    130                 135                 140                 


Thr Ile Ala His Val Thr Leu Asp Lys Asp Arg Gln Ala Trp Asn Gly 
145                 150                 155                 160 


His Tyr Phe Ile Leu Thr Asp Gln Lys Gly Gln Val His Gln Cys Ser 
                165                 170                 175     


Val Leu Phe Val Ala Thr Gly Leu Ser Val Pro Asn Gln Val Asp Phe 
            180                 185                 190         


Pro Gly Ser Glu Tyr Ala Glu Gly Tyr Glu Ser Val Ser Val Asp Pro 
        195                 200                 205             


Glu Asp Phe Val Gly Gln Asn Val Leu Ile Leu Gly Arg Gly Asn Ser 
    210                 215                 220                 


Ala Phe Glu Thr Ala Glu Asn Ile Leu Gly Val Thr Asn Phe Ile His 
225                 230                 235                 240 


Met Leu Ser Arg Ser Arg Val Arg Leu Ser Trp Ala Thr His Tyr Val 
                245                 250                 255     


Gly Asp Leu Arg Ala Ile Asn Asn Gly Leu Leu Asp Thr Tyr Gln Leu 
            260                 265                 270         


Lys Ser Leu Asp Gly Leu Leu Glu Ser Asp Leu Thr Asp Leu Ala Ile 
        275                 280                 285             


Leu Lys Asp Ser Lys Gly Lys Phe His Val Thr Pro Lys Phe Phe Leu 
    290                 295                 300                 


Glu Glu Ala Asn Thr Asn Gln Ser Ala Asp Ser Ile Thr Leu Pro Gln 
305                 310                 315                 320 


Asp Asp Asn Asp Asn Phe Ala Met Arg Val Pro Tyr Asp Arg Val Ile 
                325                 330                 335     


Arg Cys Leu Gly Trp Asn Phe Asp Phe Ser Ile Phe Asn Lys Ser Leu 
            340                 345                 350         


Arg Leu Asn Ser Gly Asn Ala Phe Gly Lys Lys Tyr Pro Leu Ile Arg 
        355                 360                 365             


Ala Ser Tyr Glu Ser Lys Gly Ser Arg Gly Leu Phe Ile Leu Gly Thr 
    370                 375                 380                 


Ala Ser His Ser Val Asp Tyr Arg Lys Ser Ala Gly Gly Phe Ile His 
385                 390                 395                 400 


Gly Phe Arg Tyr Thr Val Arg Ala Val His Arg Leu Leu Glu His Arg 
                405                 410                 415     


His His Ser Val Thr Trp Pro Ala Thr Glu Leu Pro Ile Thr Gln Leu 
            420                 425                 430         


Thr Ser Ser Ile Val Arg Arg Val Asn Glu Ala Ser Gly Leu Tyr Gln 
        435                 440                 445             


Met Phe Gly Val Leu Ala Asp Val Ile Leu Leu Lys Glu Asn Ser Thr 
    450                 455                 460                 


Ala Phe Glu Tyr Leu Glu Glu Phe Pro Ile Gln Met Leu Ala Gln Leu 
465                 470                 475                 480 


Glu Thr Leu Thr Gly Arg Lys Ala Lys His Gly Leu Phe Val Ile Asn 
                485                 490                 495     


Met Glu Tyr Gly Arg Asn Phe Ser Gly Pro Asp Lys Asp Val Phe Phe 
            500                 505                 510         


Asp Asp Arg Ser Val Gly His Thr Glu Asp Ala Trp Gln Ser Asn Phe 
        515                 520                 525             


Leu His Pro Val Ile Tyr Tyr Tyr Arg Tyr Leu Pro Thr Glu Gln Glu 
    530                 535                 540                 


Val Arg Phe Arg Pro Ala His Trp Pro Leu Pro Arg Pro Thr Ala Ile 
545                 550                 555                 560 


His His Ile Val Glu Asp Phe Leu Thr Asp Trp Thr Ala Pro Ile Gly 
                565                 570                 575     


His Ile Leu Pro Leu Arg Arg Phe Leu Glu Asn Cys Leu Asp Thr Asp 
            580                 585                 590         


Leu Arg Ser Phe Tyr Ala Glu Ser Cys Phe Leu Phe Ala Leu Thr Arg 
        595                 600                 605             


Gln Lys Leu Pro Pro Phe Cys Gln Gln Gly Tyr Leu Arg Met Gln Gly 
    610                 615                 620                 


Leu Val Ser Thr Glu Ser Leu Trp Gln His Arg Val Glu Ser Arg Leu 
625                 630                 635                 640 


Leu Arg Asp Tyr Ala Pro Thr Gly Arg Arg Leu Glu Asp Ser Ser Gln 
                645                 650                 655     


Gln Leu Gly Asp Gln Glu Pro Leu Gly Ser Pro Leu Ala Pro Gly Pro 
            660                 665                 670         


Leu Ala Gln Ser Val Asp Ser Asn Lys Glu Glu Leu 
        675                 680                 


<210>  5529
<211>  684
<212>  PRT
<213>  Homo Sapiens

<400>  5529

Met Gly Leu Ser Ala Ala Ala Pro Leu Trp Gly Pro Pro Gly Leu Leu 
1               5                   10                  15      


Leu Ala Ile Ala Leu His Pro Ala Leu Ser Val Pro Pro Arg Arg Asp 
            20                  25                  30          


Tyr Cys Val Leu Gly Ala Gly Pro Ala Gly Leu Gln Met Ala Tyr Phe 
        35                  40                  45              


Leu Gln Arg Ala Gly Arg Asp Tyr Ala Val Phe Glu Arg Ala Pro Arg 
    50                  55                  60                  


Pro Gly Ser Phe Phe Thr Arg Tyr Pro Arg His Arg Lys Leu Ile Ser 
65                  70                  75                  80  


Ile Asn Lys Arg Tyr Thr Gly Lys Ala Asn Ala Glu Phe Asn Leu Arg 
                85                  90                  95      


His Asp Trp Asn Ser Leu Leu Ser His Asp Pro Arg Leu Leu Phe Arg 
            100                 105                 110         


His Tyr Ser Arg Ala Tyr Phe Pro Asp Ala Arg Asp Met Val Arg Tyr 
        115                 120                 125             


Leu Gly Asp Phe Ala Asp Thr Leu Gly Leu Arg Val Gln Tyr Asn Thr 
    130                 135                 140                 


Thr Ile Ala His Val Thr Leu Asp Lys Asp Arg Gln Ala Trp Asn Gly 
145                 150                 155                 160 


His Tyr Phe Ile Leu Thr Asp Gln Lys Gly Gln Val His Gln Cys Ser 
                165                 170                 175     


Val Leu Phe Val Ala Thr Gly Leu Ser Val Pro Asn Gln Val Asp Phe 
            180                 185                 190         


Pro Gly Ser Glu Tyr Ala Glu Gly Tyr Glu Ser Val Ser Val Asp Pro 
        195                 200                 205             


Glu Asp Phe Val Gly Gln Asn Val Leu Ile Leu Gly Arg Gly Asn Ser 
    210                 215                 220                 


Ala Phe Glu Thr Ala Glu Asn Ile Leu Gly Val Thr Asn Phe Ile His 
225                 230                 235                 240 


Met Leu Ser Arg Ser Arg Val Arg Leu Ser Trp Ala Thr His Tyr Val 
                245                 250                 255     


Gly Asp Leu Arg Ala Ile Asn Asn Gly Leu Leu Asp Thr Tyr Gln Leu 
            260                 265                 270         


Lys Ser Leu Asp Gly Leu Leu Glu Ser Asp Leu Thr Asp Leu Ala Ile 
        275                 280                 285             


Leu Lys Asp Ser Lys Gly Lys Phe His Val Thr Pro Lys Phe Phe Leu 
    290                 295                 300                 


Glu Glu Ala Asn Thr Asn Gln Ser Ala Asp Ser Ile Thr Leu Pro Gln 
305                 310                 315                 320 


Asp Asp Asn Asp Asn Phe Ala Met Arg Val Pro Tyr Asp Arg Val Ile 
                325                 330                 335     


Arg Cys Leu Gly Trp Asn Phe Asp Phe Ser Ile Phe Asn Lys Ser Leu 
            340                 345                 350         


Arg Leu Asn Ser Gly Asn Ala Phe Gly Lys Lys Tyr Pro Leu Ile Arg 
        355                 360                 365             


Ala Ser Tyr Glu Ser Lys Gly Ser Arg Gly Leu Phe Ile Leu Gly Thr 
    370                 375                 380                 


Ala Ser His Ser Val Asp Tyr Arg Lys Ser Ala Gly Gly Phe Ile His 
385                 390                 395                 400 


Gly Phe Arg Tyr Thr Val Arg Ala Val His Arg Leu Leu Glu His Arg 
                405                 410                 415     


His His Ser Val Thr Trp Pro Ala Thr Glu Leu Pro Ile Thr Gln Leu 
            420                 425                 430         


Thr Ser Ser Ile Val Arg Arg Val Asn Glu Ala Ser Gly Leu Tyr Gln 
        435                 440                 445             


Met Phe Gly Val Leu Ala Asp Val Ile Leu Leu Lys Glu Asn Ser Thr 
    450                 455                 460                 


Ala Phe Glu Tyr Leu Glu Glu Phe Pro Ile Gln Met Leu Ala Gln Leu 
465                 470                 475                 480 


Glu Thr Leu Thr Gly Arg Lys Ala Lys His Gly Leu Phe Val Ile Asn 
                485                 490                 495     


Met Glu Tyr Gly Arg Asn Phe Ser Gly Pro Asp Lys Asp Val Phe Phe 
            500                 505                 510         


Asp Asp Arg Ser Val Gly His Thr Glu Asp Ala Trp Gln Ser Asn Phe 
        515                 520                 525             


Leu His Pro Val Ile Tyr Tyr Tyr Arg Tyr Leu Pro Thr Glu Gln Glu 
    530                 535                 540                 


Val Arg Phe Arg Pro Ala His Trp Pro Leu Pro Arg Pro Thr Ala Ile 
545                 550                 555                 560 


His His Ile Val Glu Asp Phe Leu Thr Asp Trp Thr Ala Pro Ile Gly 
                565                 570                 575     


His Ile Leu Pro Leu Arg Arg Phe Leu Glu Asn Cys Leu Asp Thr Asp 
            580                 585                 590         


Leu Arg Ser Phe Tyr Ala Glu Ser Cys Phe Leu Phe Ala Leu Thr Arg 
        595                 600                 605             


Gln Lys Leu Pro Pro Phe Cys Gln Gln Gly Tyr Leu Arg Met Gln Gly 
    610                 615                 620                 


Leu Val Ser Thr Glu Ser Leu Trp Gln His Arg Val Glu Ser Arg Leu 
625                 630                 635                 640 


Leu Arg Asp Tyr Ala Pro Thr Gly Arg Arg Leu Glu Asp Ser Ser Gln 
                645                 650                 655     


Gln Leu Gly Asp Gln Glu Pro Leu Gly Ser Pro Leu Ala Pro Gly Pro 
            660                 665                 670         


Leu Ala Gln Ser Val Asp Ser Asn Lys Glu Glu Leu 
        675                 680                 


<210>  5530
<211>  684
<212>  PRT
<213>  Homo Sapiens

<400>  5530

Met Gly Leu Ser Ala Ala Ala Pro Leu Trp Gly Pro Pro Gly Leu Leu 
1               5                   10                  15      


Leu Ala Ile Ala Leu His Pro Ala Leu Ser Val Pro Pro Arg Arg Asp 
            20                  25                  30          


Tyr Cys Val Leu Gly Ala Gly Pro Ala Gly Leu Gln Met Ala Tyr Phe 
        35                  40                  45              


Leu Gln Arg Ala Gly Arg Asp Tyr Ala Val Phe Glu Arg Ala Pro Arg 
    50                  55                  60                  


Pro Gly Ser Phe Phe Thr Arg Tyr Pro Arg His Arg Lys Leu Ile Ser 
65                  70                  75                  80  


Ile Asn Lys Arg Tyr Thr Gly Lys Ala Asn Ala Glu Phe Asn Leu Arg 
                85                  90                  95      


His Asp Trp Asn Ser Leu Leu Ser His Asp Pro Arg Leu Leu Phe Arg 
            100                 105                 110         


His Tyr Ser Arg Ala Tyr Phe Pro Asp Ala Arg Asp Met Val Arg Tyr 
        115                 120                 125             


Leu Gly Asp Phe Ala Asp Thr Leu Gly Leu Arg Val Gln Tyr Asn Thr 
    130                 135                 140                 


Thr Ile Ala His Val Thr Leu Asp Lys Asp Arg Gln Ala Trp Asn Gly 
145                 150                 155                 160 


His Tyr Phe Ile Leu Thr Asp Gln Lys Gly Gln Val His Gln Cys Ser 
                165                 170                 175     


Val Leu Phe Val Ala Thr Gly Leu Ser Val Pro Asn Gln Val Asp Phe 
            180                 185                 190         


Pro Gly Ser Glu Tyr Ala Glu Gly Tyr Glu Ser Val Ser Val Asp Pro 
        195                 200                 205             


Glu Asp Phe Val Gly Gln Asn Val Leu Ile Leu Gly Arg Gly Asn Ser 
    210                 215                 220                 


Ala Phe Glu Thr Ala Glu Asn Ile Leu Gly Val Thr Asn Phe Ile His 
225                 230                 235                 240 


Met Leu Ser Arg Ser Arg Val Arg Leu Ser Trp Ala Thr His Tyr Val 
                245                 250                 255     


Gly Asp Leu Arg Ala Ile Asn Asn Gly Leu Leu Asp Thr Tyr Gln Leu 
            260                 265                 270         


Lys Ser Leu Asp Gly Leu Leu Glu Ser Asp Leu Thr Asp Leu Ala Ile 
        275                 280                 285             


Leu Lys Asp Ser Lys Gly Lys Phe His Val Thr Pro Lys Phe Phe Leu 
    290                 295                 300                 


Glu Glu Ala Asn Thr Asn Gln Ser Ala Asp Ser Ile Thr Leu Pro Gln 
305                 310                 315                 320 


Asp Asp Asn Asp Asn Phe Ala Met Arg Val Pro Tyr Asp Arg Val Ile 
                325                 330                 335     


Arg Cys Leu Gly Trp Asn Phe Asp Phe Ser Ile Phe Asn Lys Ser Leu 
            340                 345                 350         


Arg Leu Asn Ser Gly Asn Ala Phe Gly Lys Lys Tyr Pro Leu Ile Arg 
        355                 360                 365             


Ala Ser Tyr Glu Ser Lys Gly Ser Arg Gly Leu Phe Ile Leu Gly Thr 
    370                 375                 380                 


Ala Ser His Ser Val Asp Tyr Arg Lys Ser Ala Gly Gly Phe Ile His 
385                 390                 395                 400 


Gly Phe Arg Tyr Thr Val Arg Ala Val His Arg Leu Leu Glu His Arg 
                405                 410                 415     


His His Ser Val Thr Trp Pro Ala Thr Glu Leu Pro Ile Thr Gln Leu 
            420                 425                 430         


Thr Ser Ser Ile Val Arg Arg Val Asn Glu Ala Ser Gly Leu Tyr Gln 
        435                 440                 445             


Met Phe Gly Val Leu Ala Asp Val Ile Leu Leu Lys Glu Asn Ser Thr 
    450                 455                 460                 


Ala Phe Glu Tyr Leu Glu Glu Phe Pro Ile Gln Met Leu Ala Gln Leu 
465                 470                 475                 480 


Glu Thr Leu Thr Gly Arg Lys Ala Lys His Gly Leu Phe Val Ile Asn 
                485                 490                 495     


Met Glu Tyr Gly Arg Asn Phe Ser Gly Pro Asp Lys Asp Val Phe Phe 
            500                 505                 510         


Asp Asp Arg Ser Val Gly His Thr Glu Asp Ala Trp Gln Ser Asn Phe 
        515                 520                 525             


Leu His Pro Val Ile Tyr Tyr Tyr Arg Tyr Leu Pro Thr Glu Gln Glu 
    530                 535                 540                 


Val Arg Phe Arg Pro Ala His Trp Pro Leu Pro Arg Pro Thr Ala Ile 
545                 550                 555                 560 


His His Ile Val Glu Asp Phe Leu Thr Asp Trp Thr Ala Pro Ile Gly 
                565                 570                 575     


His Ile Leu Pro Leu Arg Arg Phe Leu Glu Asn Cys Leu Asp Thr Asp 
            580                 585                 590         


Leu Arg Ser Phe Tyr Ala Glu Ser Cys Phe Leu Phe Ala Leu Thr Arg 
        595                 600                 605             


Gln Lys Leu Pro Pro Phe Cys Gln Gln Gly Tyr Leu Arg Met Gln Gly 
    610                 615                 620                 


Leu Val Ser Thr Glu Ser Leu Trp Gln His Arg Val Glu Ser Arg Leu 
625                 630                 635                 640 


Leu Arg Asp Tyr Ala Pro Thr Gly Arg Arg Leu Glu Asp Ser Ser Gln 
                645                 650                 655     


Gln Leu Gly Asp Gln Glu Pro Leu Gly Ser Pro Leu Ala Pro Gly Pro 
            660                 665                 670         


Leu Ala Gln Ser Val Asp Ser Asn Lys Glu Glu Leu 
        675                 680                 


<210>  5531
<211>  157
<212>  PRT
<213>  Homo Sapiens

<400>  5531

Met Leu Pro Glu Gln Gly Pro Gln Pro Ser Thr Met Pro Leu Trp Cys 
1               5                   10                  15      


Leu Leu Ala Ala Cys Thr Ser Leu Pro Arg Gln Ala Ala Thr Met Leu 
            20                  25                  30          


Glu Glu Ala Ala Ser Pro Asn Glu Ala Val His Ala Ser Thr Ser Gly 
        35                  40                  45              


Ser Gly Ala Leu Thr Asp Gln Thr Phe Thr Asp Leu Ser Ala Ala Glu 
    50                  55                  60                  


Ala Ser Ser Glu Glu Val Pro Asp Phe Met Glu Val Pro His Ser Val 
65                  70                  75                  80  


His His Lys Ile Asn Cys Phe Phe Tyr Leu Glu Lys Gln Leu Cys Gln 
                85                  90                  95      


Leu Pro Ser Pro Leu Cys Leu Ser Ser Leu Leu Thr Leu Lys Leu Lys 
            100                 105                 110         


Thr Thr Val Pro Ala Pro Gly Arg Trp Trp Ser Phe Gln Pro His Lys 
        115                 120                 125             


Ala Phe Pro Leu Leu Val Gly Thr Pro Gly Ser Trp Gln Ser Thr Ile 
    130                 135                 140                 


Asp Pro Ala Trp Ala Ala Pro Ser Gln Pro Ser Pro Gly 
145                 150                 155         


<210>  5532
<211>  57
<212>  PRT
<213>  Homo Sapiens

<400>  5532

Met Ala Ala Val Arg Ala Leu Val Ala Ser Arg Leu Ala Ala Ala Ser 
1               5                   10                  15      


Ala Phe Thr Ser Leu Ser Pro Gly Gly Arg Thr Pro Ser Gln Arg Ala 
            20                  25                  30          


Ala Leu His Leu Ser Val Pro Arg Pro Ala Ala Arg Val Ala Leu Asp 
        35                  40                  45              


Pro Gly Ala Pro Glu Pro Trp Arg Gly 
    50                  55          


<210>  5533
<211>  237
<212>  PRT
<213>  Homo Sapiens

<400>  5533

Met Ala Ala Val Arg Ala Leu Val Ala Ser Arg Leu Ala Ala Ala Ser 
1               5                   10                  15      


Ala Phe Thr Ser Leu Ser Pro Gly Gly Arg Thr Pro Ser Gln Arg Ala 
            20                  25                  30          


Ala Leu His Leu Ser Val Pro Arg Pro Ala Ala Arg Val Ala Leu Val 
        35                  40                  45              


Leu Ser Gly Cys Gly Val Tyr Asp Gly Thr Glu Ile His Glu Ala Ser 
    50                  55                  60                  


Ala Ile Leu Val His Leu Ser Arg Gly Gly Ala Glu Val Gln Ile Phe 
65                  70                  75                  80  


Ala Pro Asp Val Pro Gln Met His Val Ile Asp His Thr Lys Gly Gln 
                85                  90                  95      


Pro Ser Glu Gly Glu Ser Arg Asn Val Leu Thr Glu Ser Ala Arg Ile 
            100                 105                 110         


Ala Arg Gly Lys Ile Thr Asp Leu Ala Asn Leu Ser Ala Ala Asn His 
        115                 120                 125             


Asp Ala Ala Ile Phe Pro Gly Gly Phe Gly Ala Ala Lys Asn Leu Leu 
    130                 135                 140                 


Cys Cys Ile Ala Pro Val Leu Ala Ala Lys Val Leu Arg Gly Val Glu 
145                 150                 155                 160 


Val Thr Val Gly His Glu Gln Glu Glu Gly Gly Lys Trp Pro Tyr Ala 
                165                 170                 175     


Gly Thr Ala Glu Ala Ile Lys Ala Leu Gly Ala Lys His Cys Val Lys 
            180                 185                 190         


Glu Val Val Glu Ala His Val Asp Gln Lys Asn Lys Val Val Thr Thr 
        195                 200                 205             


Pro Ala Phe Met Cys Glu Thr Ala Leu His Tyr Ile His Asp Gly Ile 
    210                 215                 220                 


Gly Ala Met Val Arg Lys Val Leu Glu Leu Thr Gly Lys 
225                 230                 235         


<210>  5534
<211>  268
<212>  PRT
<213>  Homo Sapiens

<400>  5534

Met Ala Ala Val Arg Ala Leu Val Ala Ser Arg Leu Ala Ala Ala Ser 
1               5                   10                  15      


Ala Phe Thr Ser Leu Ser Pro Gly Gly Arg Thr Pro Ser Gln Arg Ala 
            20                  25                  30          


Ala Leu His Leu Ser Val Pro Arg Pro Ala Ala Arg Val Ala Leu Val 
        35                  40                  45              


Leu Ser Gly Cys Gly Val Tyr Asp Gly Thr Glu Ile His Glu Ala Ser 
    50                  55                  60                  


Ala Ile Leu Val His Leu Ser Arg Gly Gly Ala Glu Val Gln Ile Phe 
65                  70                  75                  80  


Ala Pro Asp Val Pro Gln Met His Val Ile Asp His Thr Lys Gly Gln 
                85                  90                  95      


Pro Ser Glu Gly Glu Ser Arg Asn Val Leu Thr Glu Ser Ala Arg Ile 
            100                 105                 110         


Ala Arg Gly Lys Ile Thr Asp Leu Ala Asn Leu Ser Ala Ala Asn His 
        115                 120                 125             


Asp Ala Ala Ile Phe Pro Gly Gly Phe Gly Ala Ala Lys Asn Leu Ser 
    130                 135                 140                 


Thr Phe Ala Val Asp Gly Lys Asp Cys Lys Val Asn Lys Glu Val Glu 
145                 150                 155                 160 


Arg Val Leu Lys Glu Phe His Gln Ala Gly Lys Pro Ile Gly Leu Cys 
                165                 170                 175     


Cys Ile Ala Pro Val Leu Ala Ala Lys Val Leu Arg Gly Val Glu Val 
            180                 185                 190         


Thr Val Gly His Glu Gln Glu Glu Gly Gly Lys Trp Pro Tyr Ala Gly 
        195                 200                 205             


Thr Ala Glu Ala Ile Lys Ala Leu Gly Ala Lys His Cys Val Lys Glu 
    210                 215                 220                 


Val Val Glu Ala His Val Asp Gln Lys Asn Lys Val Val Thr Thr Pro 
225                 230                 235                 240 


Ala Phe Met Cys Glu Thr Ala Leu His Tyr Ile His Asp Gly Ile Gly 
                245                 250                 255     


Ala Met Val Arg Lys Val Leu Glu Leu Thr Gly Lys 
            260                 265             


<210>  5535
<211>  182
<212>  PRT
<213>  Homo Sapiens

<400>  5535

Met His Val Ile Asp His Thr Lys Gly Gln Pro Ser Glu Gly Glu Ser 
1               5                   10                  15      


Arg Asn Val Leu Thr Glu Ser Ala Arg Ile Ala Arg Gly Lys Ile Thr 
            20                  25                  30          


Asp Leu Ala Asn Leu Ser Ala Ala Asn His Asp Ala Ala Ile Phe Pro 
        35                  40                  45              


Gly Gly Phe Gly Ala Ala Lys Asn Leu Ser Thr Phe Ala Val Asp Gly 
    50                  55                  60                  


Lys Asp Cys Lys Val Asn Lys Glu Val Glu Arg Val Leu Lys Glu Phe 
65                  70                  75                  80  


His Gln Ala Gly Lys Pro Ile Gly Leu Cys Cys Ile Ala Pro Val Leu 
                85                  90                  95      


Ala Ala Lys Val Leu Arg Gly Val Glu Val Thr Val Gly His Glu Gln 
            100                 105                 110         


Glu Glu Gly Gly Lys Trp Pro Tyr Ala Gly Thr Ala Glu Ala Ile Lys 
        115                 120                 125             


Ala Leu Gly Ala Lys His Cys Val Lys Glu Val Val Glu Ala His Val 
    130                 135                 140                 


Asp Gln Lys Asn Lys Val Val Thr Thr Pro Ala Phe Met Cys Glu Thr 
145                 150                 155                 160 


Ala Leu His Tyr Ile His Asp Gly Ile Gly Ala Met Val Arg Lys Val 
                165                 170                 175     


Leu Glu Leu Thr Gly Lys 
            180         


<210>  5536
<211>  224
<212>  PRT
<213>  Homo Sapiens

<400>  5536

Pro Ser Gln Arg Ala Ala Leu His Leu Ser Val Pro Arg Pro Ala Ala 
1               5                   10                  15      


Arg Val Ala Leu Val Leu Ser Gly Cys Gly Val Tyr Asp Gly Thr Glu 
            20                  25                  30          


Ile His Glu Ala Ser Ala Ile Leu Val His Leu Ser Arg Gly Gly Ala 
        35                  40                  45              


Glu Val Gln Ile Phe Ala Pro Asp Val Pro Gln Met His Val Ile Asp 
    50                  55                  60                  


His Thr Lys Gly Gln Pro Ser Glu Gly Glu Ser Arg Asn Val Leu Thr 
65                  70                  75                  80  


Glu Ser Ala Arg Ile Ala Arg Gly Lys Ile Thr Asp Leu Ala Asn Leu 
                85                  90                  95      


Ser Ala Ala Asn His Asp Ala Ala Ile Phe Pro Gly Gly Phe Gly Ala 
            100                 105                 110         


Ala Lys Asn Leu Ser Thr Phe Ala Val Asp Gly Lys Asp Cys Lys Val 
        115                 120                 125             


Asn Lys Glu Val Glu Arg Val Leu Lys Glu Phe His Gln Ala Gly Lys 
    130                 135                 140                 


Pro Ile Gly His Ser Leu Lys Asp Leu Pro Gly His Cys Pro Gly Arg 
145                 150                 155                 160 


Pro Leu Lys Trp Ser Leu Arg Lys Arg Cys Arg Leu Arg Ala Pro Glu 
                165                 170                 175     


Gly Gly Pro Cys Cys Ser Arg Val Thr Ala Gly Val Lys Val Ser Pro 
            180                 185                 190         


Met Val Ser Thr Ser Gly Ser Arg Pro Cys Gln Arg Ser Val Pro Trp 
        195                 200                 205             


Met Ser Ala Gln Arg Glu Glu Pro Met Ala Leu Ser Ser Val Thr Asp 
    210                 215                 220                 


<210>  5537
<211>  106
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5537

Xaa Asp Gly Thr Glu Ile His Glu Ala Ser Ala Ile Leu Val His Leu 
1               5                   10                  15      


Ser Arg Gly Gly Ala Glu Val Gln Ile Phe Ala Pro Asp Val Pro Gln 
            20                  25                  30          


Met His Val Ile Asp His Thr Lys Gly Gln Pro Ser Glu Gly Glu Ser 
        35                  40                  45              


Arg Asn Val Leu Thr Glu Ser Ala Arg Ile Ala Arg Gly Lys Ile Thr 
    50                  55                  60                  


Asp Leu Ala Asn Leu Ser Ala Ala Asn His Asp Ala Ala Ile Phe Pro 
65                  70                  75                  80  


Gly Gly Phe Gly Ala Ala Lys Asn Leu Gly Ser Pro Tyr Ser Asp Pro 
                85                  90                  95      


Ala Lys His Arg Ser Leu Gly Leu Gln Leu 
            100                 105     


<210>  5538
<211>  137
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5538

Xaa Asp Gly Thr Glu Ile His Glu Ala Ser Ala Ile Leu Val His Leu 
1               5                   10                  15      


Ser Arg Gly Gly Ala Glu Val Gln Ile Phe Ala Pro Asp Val Pro Gln 
            20                  25                  30          


Met His Val Ile Asp His Thr Lys Gly Gln Pro Ser Glu Gly Glu Ser 
        35                  40                  45              


Arg Asn Val Leu Thr Glu Ser Ala Arg Ile Ala Arg Gly Lys Ile Thr 
    50                  55                  60                  


Asp Leu Ala Asn Leu Ser Ala Ala Asn His Asp Ala Ala Ile Phe Pro 
65                  70                  75                  80  


Gly Gly Phe Gly Ala Ala Lys Asn Leu Ser Thr Phe Ala Val Asp Gly 
                85                  90                  95      


Lys Asp Cys Lys Val Asn Lys Glu Val Glu Arg Val Leu Lys Glu Phe 
            100                 105                 110         


His Gln Ala Gly Lys Pro Ile Gly Gly Ser Pro Tyr Ser Asp Pro Ala 
        115                 120                 125             


Lys His Arg Ser Leu Gly Leu Gln Leu 
    130                 135         


<210>  5539
<211>  537
<212>  PRT
<213>  Homo Sapiens

<400>  5539

Met Leu Asn Thr Leu Gln Thr Asn Ala Gly Tyr Leu Glu Gln Val Lys 
1               5                   10                  15      


Arg Gln Arg Gly Asp Pro Gln Thr Gln Leu Glu Ala Met Glu Leu Tyr 
            20                  25                  30          


Leu Ala Arg Ser Gly Leu Gln Val Glu Asp Leu Asp Arg Leu Asn Ile 
        35                  40                  45              


Ile His Val Thr Gly Thr Lys Gly Lys Gly Ser Thr Cys Ala Phe Thr 
    50                  55                  60                  


Glu Cys Ile Leu Arg Ser Tyr Gly Leu Lys Thr Gly Phe Phe Ser Ser 
65                  70                  75                  80  


Pro His Leu Val Gln Val Arg Glu Arg Ile Arg Ile Asn Gly Gln Pro 
                85                  90                  95      


Ile Ser Pro Glu Leu Phe Thr Lys Tyr Phe Trp Arg Leu Tyr His Arg 
            100                 105                 110         


Leu Glu Glu Thr Lys Asp Gly Ser Cys Val Ser Met Pro Pro Tyr Phe 
        115                 120                 125             


Arg Phe Leu Thr Leu Met Ala Phe His Val Phe Leu Gln Glu Lys Val 
    130                 135                 140                 


Asp Leu Ala Val Val Glu Val Gly Ile Gly Gly Ala Tyr Asp Cys Thr 
145                 150                 155                 160 


Asn Ile Ile Arg Lys Pro Val Val Cys Gly Val Ser Ser Leu Gly Ile 
                165                 170                 175     


Asp His Thr Ser Leu Leu Gly Asp Thr Val Glu Lys Ile Ala Trp Gln 
            180                 185                 190         


Lys Gly Gly Ile Phe Lys Gln Gly Val Pro Ala Phe Thr Val Leu Gln 
        195                 200                 205             


Pro Glu Gly Pro Leu Ala Val Leu Arg Asp Arg Ala Gln Gln Ile Ser 
    210                 215                 220                 


Cys Pro Leu Tyr Leu Cys Pro Met Leu Glu Ala Leu Glu Glu Gly Gly 
225                 230                 235                 240 


Pro Pro Leu Thr Leu Gly Leu Glu Gly Glu His Gln Arg Ser Asn Ala 
                245                 250                 255     


Ala Leu Ala Leu Gln Leu Ala His Cys Trp Leu Gln Arg Gln Asp Arg 
            260                 265                 270         


His Gly Ala Gly Glu Pro Lys Ala Ser Arg Pro Gly Leu Leu Trp Gln 
        275                 280                 285             


Leu Pro Leu Ala Pro Val Phe Gln Pro Thr Ser His Met Arg Leu Gly 
    290                 295                 300                 


Leu Arg Asn Thr Glu Trp Pro Gly Arg Thr Gln Val Leu Arg Arg Gly 
305                 310                 315                 320 


Pro Leu Thr Trp Tyr Leu Asp Gly Ala His Thr Ala Ser Ser Ala Gln 
                325                 330                 335     


Ala Cys Val Arg Trp Phe Arg Gln Ala Leu Gln Gly Arg Glu Arg Pro 
            340                 345                 350         


Ser Gly Gly Pro Glu Val Arg Val Leu Leu Phe Asn Ala Thr Gly Asp 
        355                 360                 365             


Arg Asp Pro Ala Ala Leu Leu Lys Leu Leu Gln Pro Cys Gln Phe Asp 
    370                 375                 380                 


Tyr Ala Val Phe Cys Pro Asn Leu Thr Glu Val Ser Ser Thr Gly Asn 
385                 390                 395                 400 


Ala Asp Gln Gln Asn Phe Thr Val Thr Leu Asp Gln Val Leu Leu Arg 
                405                 410                 415     


Cys Leu Glu His Gln Gln His Trp Asn His Leu Asp Glu Glu Gln Ala 
            420                 425                 430         


Ser Pro Asp Leu Trp Ser Ala Pro Ser Pro Glu Pro Gly Gly Ser Ala 
        435                 440                 445             


Ser Leu Leu Leu Ala Pro His Pro Pro His Thr Cys Ser Ala Ser Ser 
    450                 455                 460                 


Leu Val Phe Ser Cys Ile Ser His Ala Leu Gln Trp Ile Ser Gln Gly 
465                 470                 475                 480 


Arg Asp Pro Ile Phe Gln Pro Pro Ser Pro Pro Lys Gly Leu Leu Thr 
                485                 490                 495     


His Pro Val Ala His Ser Gly Ala Ser Ile Leu Arg Glu Ala Ala Ala 
            500                 505                 510         


Ile His Val Leu Val Thr Gly Ser Leu His Leu Val Gly Gly Val Leu 
        515                 520                 525             


Lys Leu Leu Glu Pro Ala Leu Ser Gln 
    530                 535         


<210>  5540
<211>  265
<212>  PRT
<213>  Homo Sapiens

<400>  5540

Met Leu Asn Thr Leu Gln Thr Asn Ala Gly Tyr Leu Glu Gln Val Lys 
1               5                   10                  15      


Arg Gln Arg Gly Asp Pro Gln Thr Gln Leu Glu Ala Met Glu Leu Tyr 
            20                  25                  30          


Leu Ala Arg Ser Gly Leu Gln Val Glu Asp Leu Asp Arg Leu Asn Ile 
        35                  40                  45              


Ile His Val Thr Gly Thr Lys Gly Lys Gly Ser Thr Cys Ala Phe Thr 
    50                  55                  60                  


Glu Cys Ile Leu Arg Ser Tyr Gly Leu Lys Thr Gly Phe Phe Ser Ser 
65                  70                  75                  80  


Pro His Leu Val Gln Val Arg Glu Arg Ile Arg Ile Asn Gly Gln Pro 
                85                  90                  95      


Ile Ser Pro Glu Leu Phe Thr Lys Tyr Phe Trp Arg Leu Tyr His Arg 
            100                 105                 110         


Leu Glu Glu Thr Lys Asp Gly Ser Cys Val Ser Met Pro Pro Tyr Phe 
        115                 120                 125             


Arg Phe Leu Thr Leu Met Ala Phe His Val Phe Leu Gln Glu Lys Val 
    130                 135                 140                 


Asp Leu Ala Val Val Glu Val Gly Ile Gly Gly Ala Tyr Asp Cys Thr 
145                 150                 155                 160 


Asn Ile Ile Arg Lys Pro Val Val Cys Gly Val Ser Ser Leu Gly Ile 
                165                 170                 175     


Asp His Thr Ser Leu Leu Gly Asp Thr Val Glu Lys Ile Ala Trp Gln 
            180                 185                 190         


Lys Gly Gly Ile Phe Lys Gln Gly Val Pro Ala Phe Thr Val Leu Gln 
        195                 200                 205             


Pro Glu Gly Pro Leu Ala Val Leu Arg Asp Arg Ala Gln Gln Ile Ser 
    210                 215                 220                 


Val Leu Gly Ser Gln Arg His Pro Gly Gln Gly Ser Cys Gly Ser Cys 
225                 230                 235                 240 


Pro Trp His Leu Cys Ser Ser Pro His Pro Thr Cys Gly Ser Gly Phe 
                245                 250                 255     


Gly Thr Arg Ser Gly Arg Ala Gly Arg 
            260                 265 


<210>  5541
<211>  194
<212>  PRT
<213>  Homo Sapiens

<400>  5541

Met Leu Asn Thr Leu Gln Thr Asn Ala Gly Tyr Leu Glu Gln Val Lys 
1               5                   10                  15      


Arg Gln Arg Gly Asp Pro Gln Thr Gln Leu Glu Ala Met Glu Leu Tyr 
            20                  25                  30          


Leu Ala Arg Ser Gly Leu Gln Val Glu Asp Leu Asp Arg Leu Asn Ile 
        35                  40                  45              


Ile His Val Thr Gly Thr Lys Gly Lys Gly Ser Thr Cys Ala Phe Thr 
    50                  55                  60                  


Glu Cys Ile Leu Arg Ser Tyr Gly Leu Lys Thr Gly Phe Phe Ser Ser 
65                  70                  75                  80  


Pro His Leu Val Gln Val Arg Glu Arg Ile Arg Ile Asn Gly Gln Pro 
                85                  90                  95      


Ile Ser Pro Glu Leu Phe Thr Lys Tyr Phe Trp Arg Leu Tyr His Arg 
            100                 105                 110         


Leu Glu Glu Thr Lys Val Asp Leu Ala Val Val Glu Val Gly Ile Gly 
        115                 120                 125             


Gly Ala Tyr Asp Cys Thr Asn Ile Ile Arg Lys Pro Val Val Cys Gly 
    130                 135                 140                 


Val Ser Ser Leu Gly Ile Asp His Thr Ser Leu Leu Gly Asp Thr Val 
145                 150                 155                 160 


Glu Lys Ile Ala Trp Gln Lys Gly Gly Ile Phe Lys Gln Gly Val Pro 
                165                 170                 175     


Ala Phe Thr Val Leu Gln Pro Glu Gly Pro Leu Ala Val Leu Arg Asp 
            180                 185                 190         


Arg Ala 
        


<210>  5542
<211>  375
<212>  PRT
<213>  Homo Sapiens

<400>  5542

Met Ser Arg Ala Arg Ser His Leu Arg Ala Ala Leu Phe Leu Ala Ala 
1               5                   10                  15      


Ala Ser Ala Arg Gly Ile Thr Thr Gln Val Ala Ala Arg Arg Gly Leu 
            20                  25                  30          


Ser Ala Trp Pro Val Pro Gln Glu Pro Ser Met Glu Tyr Gln Asp Ala 
        35                  40                  45              


Val Arg Met Leu Asn Thr Leu Gln Thr Asn Ala Gly Tyr Leu Glu Gln 
    50                  55                  60                  


Val Lys Arg Gln Arg Gly Asp Pro Gln Thr Gln Leu Glu Ala Met Glu 
65                  70                  75                  80  


Leu Tyr Leu Ala Arg Ser Gly Leu Gln Val Glu Asp Leu Asp Arg Leu 
                85                  90                  95      


Asn Ile Ile His Val Thr Gly Thr Lys Gly Lys Gly Ser Thr Cys Ala 
            100                 105                 110         


Phe Thr Glu Cys Ile Leu Arg Ser Tyr Gly Leu Lys Thr Gly Phe Phe 
        115                 120                 125             


Ser Ser Pro His Leu Val Gln Val Arg Glu Arg Ile Arg Ile Asn Gly 
    130                 135                 140                 


Gln Pro Ile Ser Pro Glu Leu Phe Thr Lys Tyr Phe Trp Arg Leu Tyr 
145                 150                 155                 160 


His Arg Leu Glu Glu Thr Lys Asp Gly Ser Cys Val Ser Met Pro Pro 
                165                 170                 175     


Tyr Phe Arg Phe Leu Thr Leu Met Ala Phe His Val Phe Leu Gln Glu 
            180                 185                 190         


Lys Val Asp Leu Ala Val Val Glu Val Gly Ile Gly Gly Ala Tyr Asp 
        195                 200                 205             


Cys Thr Asn Ile Ile Arg Lys Pro Val Val Cys Gly Val Ser Ser Leu 
    210                 215                 220                 


Gly Ile Asp His Thr Ser Leu Leu Gly Asp Thr Val Glu Lys Ile Ala 
225                 230                 235                 240 


Trp Gln Lys Gly Gly Ile Phe Lys Gln Gly Val Pro Ala Phe Thr Val 
                245                 250                 255     


Leu Gln Pro Glu Gly Pro Leu Ala Val Leu Arg Asp Arg Ala Gln Gln 
            260                 265                 270         


Ile Ser Val Leu Gly Ser Gln Arg His Pro Gly Gln Gly Ser Cys Gly 
        275                 280                 285             


Ser Cys Pro Trp His Leu Cys Ser Ser Pro His Pro Thr Cys Gly Ser 
    290                 295                 300                 


Gly Phe Gly Thr Arg Ser Gly Arg Ala Gly Arg Arg Cys Cys Gly Ala 
305                 310                 315                 320 


Gly Pro Ser Pro Gly Thr Trp Thr Val Arg Thr Pro Pro Ala Ala Arg 
                325                 330                 335     


Arg Pro Ala Cys Ala Gly Ser Ala Arg Arg Cys Arg Ala Ala Arg Gly 
            340                 345                 350         


Arg Ala Val Ala Pro Arg Phe Glu Ser Cys Ser Ser Met Leu Pro Gly 
        355                 360                 365             


Thr Gly Thr Arg Arg Pro Cys 
    370                 375 


<210>  5543
<211>  587
<212>  PRT
<213>  Homo Sapiens

<400>  5543

Met Ser Arg Ala Arg Ser His Leu Arg Ala Ala Leu Phe Leu Ala Ala 
1               5                   10                  15      


Ala Ser Ala Arg Gly Ile Thr Thr Gln Val Ala Ala Arg Arg Gly Leu 
            20                  25                  30          


Ser Ala Trp Pro Val Pro Gln Glu Pro Ser Met Glu Tyr Gln Asp Ala 
        35                  40                  45              


Val Arg Met Leu Asn Thr Leu Gln Thr Asn Ala Gly Tyr Leu Glu Gln 
    50                  55                  60                  


Val Lys Arg Gln Arg Gly Asp Pro Gln Thr Gln Leu Glu Ala Met Glu 
65                  70                  75                  80  


Leu Tyr Leu Ala Arg Ser Gly Leu Gln Val Glu Asp Leu Asp Arg Leu 
                85                  90                  95      


Asn Ile Ile His Val Thr Gly Thr Lys Gly Lys Gly Ser Thr Cys Ala 
            100                 105                 110         


Phe Thr Glu Cys Ile Leu Arg Ser Tyr Gly Leu Lys Thr Gly Phe Phe 
        115                 120                 125             


Ser Ser Pro His Leu Val Gln Val Arg Glu Arg Ile Arg Ile Asn Gly 
    130                 135                 140                 


Gln Pro Ile Ser Pro Glu Leu Phe Thr Lys Tyr Phe Trp Arg Leu Tyr 
145                 150                 155                 160 


His Arg Leu Glu Glu Thr Lys Asp Gly Ser Cys Val Ser Met Pro Pro 
                165                 170                 175     


Tyr Phe Arg Phe Leu Thr Leu Met Ala Phe His Val Phe Leu Gln Glu 
            180                 185                 190         


Lys Val Asp Leu Ala Val Val Glu Val Gly Ile Gly Gly Ala Tyr Asp 
        195                 200                 205             


Cys Thr Asn Ile Ile Arg Lys Pro Val Val Cys Gly Val Ser Ser Leu 
    210                 215                 220                 


Gly Ile Asp His Thr Ser Leu Leu Gly Asp Thr Val Glu Lys Ile Ala 
225                 230                 235                 240 


Trp Gln Lys Gly Gly Ile Phe Lys Gln Gly Val Pro Ala Phe Thr Val 
                245                 250                 255     


Leu Gln Pro Glu Gly Pro Leu Ala Val Leu Arg Asp Arg Ala Gln Gln 
            260                 265                 270         


Ile Ser Cys Pro Leu Tyr Leu Cys Pro Met Leu Glu Ala Leu Glu Glu 
        275                 280                 285             


Gly Gly Pro Pro Leu Thr Leu Gly Leu Glu Gly Glu His Gln Arg Ser 
    290                 295                 300                 


Asn Ala Ala Leu Ala Leu Gln Leu Ala His Cys Trp Leu Gln Arg Gln 
305                 310                 315                 320 


Asp Arg His Gly Ala Gly Glu Pro Lys Ala Ser Arg Pro Gly Leu Leu 
                325                 330                 335     


Trp Gln Leu Pro Leu Ala Pro Val Phe Gln Pro Thr Ser His Met Arg 
            340                 345                 350         


Leu Gly Leu Arg Asn Thr Glu Trp Pro Gly Arg Thr Gln Val Leu Arg 
        355                 360                 365             


Arg Gly Pro Leu Thr Trp Tyr Leu Asp Gly Ala His Thr Ala Ser Ser 
    370                 375                 380                 


Ala Gln Ala Cys Val Arg Trp Phe Arg Gln Ala Leu Gln Gly Arg Glu 
385                 390                 395                 400 


Arg Pro Ser Gly Gly Pro Glu Val Arg Val Leu Leu Phe Asn Ala Thr 
                405                 410                 415     


Gly Asp Arg Asp Pro Ala Ala Leu Leu Lys Leu Leu Gln Pro Cys Gln 
            420                 425                 430         


Phe Asp Tyr Ala Val Phe Cys Pro Asn Leu Thr Glu Val Ser Ser Thr 
        435                 440                 445             


Gly Asn Ala Asp Gln Gln Asn Phe Thr Val Thr Leu Asp Gln Val Leu 
    450                 455                 460                 


Leu Arg Cys Leu Glu His Gln Gln His Trp Asn His Leu Asp Glu Glu 
465                 470                 475                 480 


Gln Ala Ser Pro Asp Leu Trp Ser Ala Pro Ser Pro Glu Pro Gly Gly 
                485                 490                 495     


Ser Ala Ser Leu Leu Leu Ala Pro His Pro Pro His Thr Cys Ser Ala 
            500                 505                 510         


Ser Ser Leu Val Phe Ser Cys Ile Ser His Ala Leu Gln Trp Ile Ser 
        515                 520                 525             


Gln Gly Arg Asp Pro Ile Phe Gln Pro Pro Ser Pro Pro Lys Gly Leu 
    530                 535                 540                 


Leu Thr His Pro Val Ala His Ser Gly Ala Ser Ile Leu Arg Glu Ala 
545                 550                 555                 560 


Ala Ala Ile His Val Leu Val Thr Gly Ser Leu His Leu Val Gly Gly 
                565                 570                 575     


Val Leu Lys Leu Leu Glu Pro Ala Leu Ser Gln 
            580                 585         


<210>  5544
<211>  375
<212>  PRT
<213>  Homo Sapiens

<400>  5544

Met Ser Arg Ala Arg Ser His Leu Arg Ala Ala Leu Phe Leu Ala Ala 
1               5                   10                  15      


Ala Ser Ala Arg Gly Ile Thr Thr Gln Val Ala Ala Arg Arg Gly Leu 
            20                  25                  30          


Ser Ala Trp Pro Val Pro Gln Glu Pro Ser Met Glu Tyr Gln Asp Ala 
        35                  40                  45              


Val Arg Met Leu Asn Thr Leu Gln Thr Asn Ala Gly Tyr Leu Glu Gln 
    50                  55                  60                  


Val Lys Arg Gln Arg Gly Asp Pro Gln Thr Gln Leu Glu Ala Met Glu 
65                  70                  75                  80  


Leu Tyr Leu Ala Arg Ser Gly Leu Gln Val Glu Asp Leu Asp Arg Leu 
                85                  90                  95      


Asn Ile Ile His Val Thr Gly Thr Lys Gly Lys Gly Ser Thr Cys Ala 
            100                 105                 110         


Phe Thr Glu Cys Ile Leu Arg Ser Tyr Gly Leu Lys Thr Gly Phe Phe 
        115                 120                 125             


Ser Ser Pro His Leu Val Gln Val Arg Glu Arg Ile Arg Ile Asn Gly 
    130                 135                 140                 


Gln Pro Ile Ser Pro Glu Leu Phe Thr Lys Tyr Phe Trp Arg Leu Tyr 
145                 150                 155                 160 


His Arg Leu Glu Glu Thr Lys Asp Gly Ser Cys Val Ser Met Pro Pro 
                165                 170                 175     


Tyr Phe Arg Phe Leu Thr Leu Met Ala Phe His Val Phe Leu Gln Glu 
            180                 185                 190         


Lys Val Asp Leu Ala Val Val Glu Val Gly Ile Gly Gly Ala Tyr Asp 
        195                 200                 205             


Cys Thr Asn Ile Ile Arg Lys Pro Val Val Cys Gly Val Ser Ser Leu 
    210                 215                 220                 


Gly Ile Asp His Thr Ser Leu Leu Gly Asp Thr Val Glu Lys Ile Ala 
225                 230                 235                 240 


Trp Gln Lys Gly Gly Ile Phe Lys Gln Gly Val Pro Ala Phe Thr Val 
                245                 250                 255     


Leu Gln Pro Glu Gly Pro Leu Ala Val Leu Arg Asp Arg Ala Gln Gln 
            260                 265                 270         


Ile Ser Val Leu Gly Ser Gln Arg His Pro Gly Gln Gly Ser Cys Gly 
        275                 280                 285             


Ser Cys Pro Trp His Leu Cys Ser Ser Pro His Pro Thr Cys Gly Ser 
    290                 295                 300                 


Gly Phe Gly Thr Arg Ser Gly Arg Ala Gly Arg Arg Cys Cys Gly Ala 
305                 310                 315                 320 


Gly Pro Ser Pro Gly Thr Trp Thr Val Arg Thr Pro Pro Ala Ala Arg 
                325                 330                 335     


Arg Pro Ala Cys Ala Gly Ser Ala Arg Arg Cys Arg Ala Ala Arg Gly 
            340                 345                 350         


Arg Ala Val Ala Pro Arg Phe Glu Ser Cys Ser Ser Met Leu Pro Gly 
        355                 360                 365             


Thr Gly Thr Arg Arg Pro Cys 
    370                 375 


<210>  5545
<211>  561
<212>  PRT
<213>  Homo Sapiens

<400>  5545

Met Ser Arg Ala Arg Ser His Leu Arg Ala Ala Leu Phe Leu Ala Ala 
1               5                   10                  15      


Ala Ser Ala Arg Gly Ile Thr Thr Gln Val Ala Ala Arg Arg Gly Leu 
            20                  25                  30          


Ser Ala Trp Pro Val Pro Gln Glu Pro Ser Met Glu Tyr Gln Asp Ala 
        35                  40                  45              


Val Arg Met Leu Asn Thr Leu Gln Thr Asn Ala Gly Tyr Leu Glu Gln 
    50                  55                  60                  


Val Lys Arg Gln Arg Gly Asp Pro Gln Thr Gln Leu Glu Ala Met Glu 
65                  70                  75                  80  


Leu Tyr Leu Ala Arg Ser Gly Leu Gln Val Glu Asp Leu Asp Arg Leu 
                85                  90                  95      


Asn Ile Ile His Val Thr Gly Thr Lys Gly Lys Gly Ser Thr Cys Ala 
            100                 105                 110         


Phe Thr Glu Cys Ile Leu Arg Ser Tyr Gly Leu Lys Thr Gly Phe Phe 
        115                 120                 125             


Ser Ser Pro His Leu Val Gln Val Arg Glu Arg Ile Arg Ile Asn Gly 
    130                 135                 140                 


Gln Pro Ile Ser Pro Glu Leu Phe Thr Lys Tyr Phe Trp Arg Leu Tyr 
145                 150                 155                 160 


His Arg Leu Glu Glu Thr Lys Val Asp Leu Ala Val Val Glu Val Gly 
                165                 170                 175     


Ile Gly Gly Ala Tyr Asp Cys Thr Asn Ile Ile Arg Lys Pro Val Val 
            180                 185                 190         


Cys Gly Val Ser Ser Leu Gly Ile Asp His Thr Ser Leu Leu Gly Asp 
        195                 200                 205             


Thr Val Glu Lys Ile Ala Trp Gln Lys Gly Gly Ile Phe Lys Gln Gly 
    210                 215                 220                 


Val Pro Ala Phe Thr Val Leu Gln Pro Glu Gly Pro Leu Ala Val Leu 
225                 230                 235                 240 


Arg Asp Arg Ala Gln Gln Ile Ser Cys Pro Leu Tyr Leu Cys Pro Met 
                245                 250                 255     


Leu Glu Ala Leu Glu Glu Gly Gly Pro Pro Leu Thr Leu Gly Leu Glu 
            260                 265                 270         


Gly Glu His Gln Arg Ser Asn Ala Ala Leu Ala Leu Gln Leu Ala His 
        275                 280                 285             


Cys Trp Leu Gln Arg Gln Asp Arg His Gly Ala Gly Glu Pro Lys Ala 
    290                 295                 300                 


Ser Arg Pro Gly Leu Leu Trp Gln Leu Pro Leu Ala Pro Val Phe Gln 
305                 310                 315                 320 


Pro Thr Ser His Met Arg Leu Gly Leu Arg Asn Thr Glu Trp Pro Gly 
                325                 330                 335     


Arg Thr Gln Val Leu Arg Arg Gly Pro Leu Thr Trp Tyr Leu Asp Gly 
            340                 345                 350         


Ala His Thr Ala Ser Ser Ala Gln Ala Cys Val Arg Trp Phe Arg Gln 
        355                 360                 365             


Ala Leu Gln Gly Arg Glu Arg Pro Ser Gly Gly Pro Glu Val Arg Val 
    370                 375                 380                 


Leu Leu Phe Asn Ala Thr Gly Asp Arg Asp Pro Ala Ala Leu Leu Lys 
385                 390                 395                 400 


Leu Leu Gln Pro Cys Gln Phe Asp Tyr Ala Val Phe Cys Pro Asn Leu 
                405                 410                 415     


Thr Glu Val Ser Ser Thr Gly Asn Ala Asp Gln Gln Asn Phe Thr Val 
            420                 425                 430         


Thr Leu Asp Gln Val Leu Leu Arg Cys Leu Glu His Gln Gln His Trp 
        435                 440                 445             


Asn His Leu Asp Glu Glu Gln Ala Ser Pro Asp Leu Trp Ser Ala Pro 
    450                 455                 460                 


Ser Pro Glu Pro Gly Gly Ser Ala Ser Leu Leu Leu Ala Pro His Pro 
465                 470                 475                 480 


Pro His Thr Cys Ser Ala Ser Ser Leu Val Phe Ser Cys Ile Ser His 
                485                 490                 495     


Ala Leu Gln Trp Ile Ser Gln Gly Arg Asp Pro Ile Phe Gln Pro Pro 
            500                 505                 510         


Ser Pro Pro Lys Gly Leu Leu Thr His Pro Val Ala His Ser Gly Ala 
        515                 520                 525             


Ser Ile Leu Arg Glu Ala Ala Ala Ile His Val Leu Val Thr Gly Ser 
    530                 535                 540                 


Leu His Leu Val Gly Gly Val Leu Lys Leu Leu Glu Pro Ala Leu Ser 
545                 550                 555                 560 


Gln 
    


<210>  5546
<211>  1976
<212>  PRT
<213>  Homo Sapiens

<400>  5546

Met Gly Val Leu Lys Val Trp Leu Gly Leu Ala Leu Ala Leu Ala Glu 
1               5                   10                  15      


Phe Ala Val Leu Pro His His Ser Glu Gly Ala Cys Val Tyr Gln Asp 
            20                  25                  30          


Ser Leu Leu Ala Asp Ala Thr Ile Trp Lys Pro Asp Ser Cys Gln Ser 
        35                  40                  45              


Cys Arg Cys His Gly Asp Ile Val Ile Cys Lys Pro Ala Val Cys Arg 
    50                  55                  60                  


Asn Pro Gln Cys Ala Phe Glu Lys Gly Glu Val Leu Gln Ile Ala Ala 
65                  70                  75                  80  


Asn Gln Cys Cys Pro Glu Cys Val Leu Arg Thr Pro Gly Ser Cys His 
                85                  90                  95      


His Glu Lys Lys Ile His Glu His Gly Thr Glu Trp Ala Ser Ser Pro 
            100                 105                 110         


Cys Ser Val Cys Ser Cys Asn His Gly Glu Val Arg Cys Thr Pro Gln 
        115                 120                 125             


Pro Cys Pro Pro Leu Ser Cys Gly His Gln Glu Leu Ala Phe Ile Pro 
    130                 135                 140                 


Glu Gly Ser Cys Cys Pro Val Cys Val Gly Leu Gly Lys Pro Cys Ser 
145                 150                 155                 160 


Tyr Glu Gly His Val Phe Gln Asp Gly Glu Asp Trp Arg Leu Ser Arg 
                165                 170                 175     


Cys Ala Lys Cys Leu Cys Arg Asn Gly Val Ala Gln Cys Phe Thr Ala 
            180                 185                 190         


Gln Cys Gln Pro Leu Phe Cys Asn Gln Asp Glu Thr Val Val Arg Val 
        195                 200                 205             


Pro Gly Lys Cys Cys Pro Gln Cys Ser Ala Arg Ser Cys Ser Ala Ala 
    210                 215                 220                 


Gly Gln Val Tyr Glu His Gly Glu Gln Trp Ser Glu Asn Ala Cys Thr 
225                 230                 235                 240 


Thr Cys Ile Cys Asp Arg Gly Glu Val Arg Cys His Lys Gln Ala Cys 
                245                 250                 255     


Leu Pro Leu Arg Cys Gly Lys Gly Gln Ser Arg Ala Arg Arg His Gly 
            260                 265                 270         


Gln Cys Cys Glu Glu Cys Val Ser Pro Ala Gly Ser Cys Ser Tyr Asp 
        275                 280                 285             


Gly Val Val Arg Tyr Gln Asp Glu Met Trp Lys Gly Ser Ala Cys Glu 
    290                 295                 300                 


Phe Cys Met Cys Asp His Gly Gln Val Thr Cys Gln Thr Gly Glu Cys 
305                 310                 315                 320 


Ala Lys Val Glu Cys Ala Arg Asp Glu Glu Leu Ile His Leu Asp Gly 
                325                 330                 335     


Lys Cys Cys Pro Glu Cys Ile Ser Arg Asn Gly Tyr Cys Val Tyr Glu 
            340                 345                 350         


Glu Thr Gly Glu Phe Met Ser Ser Asn Ala Ser Glu Val Lys Arg Ile 
        355                 360                 365             


Pro Glu Gly Glu Lys Trp Glu Asp Gly Pro Cys Lys Val Cys Glu Cys 
    370                 375                 380                 


Arg Gly Ala Gln Val Thr Cys Tyr Glu Pro Ser Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Val Gly Thr Leu Ala Leu Glu Val Lys Gly Gln Cys Cys Pro Asp Cys 
                405                 410                 415     


Thr Ser Val His Cys His Pro Asp Cys Leu Thr Cys Ser Gln Ser Pro 
            420                 425                 430         


Asp His Cys Asp Leu Cys Gln Asp Pro Thr Lys Leu Leu Gln Asn Gly 
        435                 440                 445             


Trp Cys Val His Ser Cys Gly Leu Gly Phe Tyr Gln Ala Gly Ser Leu 
    450                 455                 460                 


Cys Leu Ala Cys Gln Pro Gln Cys Ser Thr Cys Thr Ser Gly Leu Glu 
465                 470                 475                 480 


Cys Ser Ser Cys Gln Pro Pro Leu Leu Met Arg His Gly Gln Cys Val 
                485                 490                 495     


Pro Thr Cys Gly Asp Gly Phe Tyr Gln Asp Arg His Ser Cys Ala Val 
            500                 505                 510         


Cys His Glu Ser Cys Ala Gly Cys Trp Gly Pro Thr Glu Lys His Cys 
        515                 520                 525             


Leu Ala Cys Arg Asp Pro Leu His Val Leu Arg Asp Gly Gly Cys Glu 
    530                 535                 540                 


Ser Ser Cys Gly Lys Gly Phe Tyr Asn Arg Gln Gly Thr Cys Ser Ala 
545                 550                 555                 560 


Cys Asp Gln Ser Cys Asp Ser Cys Gly Pro Ser Ser Pro Arg Cys Leu 
                565                 570                 575     


Thr Cys Thr Glu Lys Thr Val Leu His Asp Gly Lys Cys Met Ser Glu 
            580                 585                 590         


Cys Pro Gly Gly Tyr Tyr Ala Asp Ala Thr Gly Arg Cys Lys Val Cys 
        595                 600                 605             


His Asn Ser Cys Ala Ser Cys Ser Gly Pro Thr Pro Ser His Cys Thr 
    610                 615                 620                 


Ala Cys Ser Pro Pro Lys Ala Leu Arg Gln Gly His Cys Leu Pro Arg 
625                 630                 635                 640 


Cys Gly Glu Gly Phe Tyr Ser Asp His Gly Val Cys Lys Ala Cys His 
                645                 650                 655     


Ser Ser Cys Leu Ala Cys Met Gly Pro Ala Pro Ser His Cys Thr Gly 
            660                 665                 670         


Cys Lys Lys Pro Glu Glu Gly Leu Gln Val Glu Gln Leu Ser Asp Val 
        675                 680                 685             


Gly Ile Pro Ser Gly Glu Cys Leu Ala Gln Cys Arg Ala His Phe Tyr 
    690                 695                 700                 


Leu Glu Ser Thr Gly Ile Cys Glu Ala Cys His Gln Ser Cys Phe Arg 
705                 710                 715                 720 


Cys Ala Gly Lys Ser Pro His Asn Cys Thr Asp Cys Gly Pro Ser His 
                725                 730                 735     


Val Leu Leu Asp Gly Gln Cys Leu Ser Gln Cys Pro Asp Gly Tyr Phe 
            740                 745                 750         


His Gln Glu Gly Ser Cys Thr Glu Cys His Pro Thr Cys Arg Gln Cys 
        755                 760                 765             


His Gly Pro Leu Glu Ser Asp Cys Ile Ser Cys Tyr Pro His Ile Ser 
    770                 775                 780                 


Leu Thr Asn Gly Asn Cys Arg Thr Ser Cys Arg Glu Glu Gln Phe Leu 
785                 790                 795                 800 


Asn Leu Val Gly Tyr Cys Ala Asp Cys His His Leu Cys Gln His Cys 
                805                 810                 815     


Ala Ala Asp Leu His Asn Thr Gly Ser Ile Cys Leu Arg Cys Gln Asn 
            820                 825                 830         


Ala His Tyr Leu Leu Leu Gly Asp His Cys Val Pro Asp Cys Pro Ser 
        835                 840                 845             


Gly Tyr Tyr Ala Glu Arg Gly Ala Cys Lys Lys Cys His Ser Ser Cys 
    850                 855                 860                 


Arg Thr Cys Gln Gly Arg Gly Pro Phe Ser Cys Ser Ser Cys Asp Thr 
865                 870                 875                 880 


Asn Leu Val Leu Ser His Thr Gly Thr Cys Ser Thr Thr Cys Phe Pro 
                885                 890                 895     


Gly His Tyr Leu Asp Asp Asn His Val Cys Gln Pro Cys Asn Thr His 
            900                 905                 910         


Cys Gly Ser Cys Asp Ser Gln Ala Ser Cys Thr Ser Cys Arg Asp Pro 
        915                 920                 925             


Asn Lys Val Leu Leu Phe Gly Glu Cys Gln Tyr Glu Ser Cys Ala Pro 
    930                 935                 940                 


Gln Tyr Tyr Leu Asp Phe Ser Thr Asn Thr Cys Lys Glu Cys Asp Trp 
945                 950                 955                 960 


Ser Cys Ser Ala Cys Ser Gly Pro Leu Lys Thr Asp Cys Leu Gln Cys 
                965                 970                 975     


Met Asp Gly Tyr Val Leu Gln Asp Gly Ala Cys Val Glu Gln Cys Leu 
            980                 985                 990         


Ser Ser Phe Tyr Gln Asp Ser Gly  Leu Cys Lys Asn Cys  Asp Ser Tyr 
        995                 1000                 1005             


Cys Leu  Gln Cys Gln Gly Pro  His Glu Cys Thr Arg  Cys Lys Gly 
    1010                 1015                 1020             


Pro Phe  Leu Leu Leu Glu Ala  Gln Cys Val Gln Glu  Cys Gly Lys 
    1025                 1030                 1035             


Gly Tyr  Phe Ala Asp His Ala  Lys His Lys Cys Thr  Ala Cys Pro 
    1040                 1045                 1050             


Gln Gly  Cys Leu Gln Cys Ser  His Arg Asp Arg Cys  His Leu Cys 
    1055                 1060                 1065             


Asp His  Gly Phe Phe Leu Lys  Ser Gly Leu Cys Val  Tyr Asn Cys 
    1070                 1075                 1080             


Val Pro  Gly Phe Ser Val His  Thr Ser Asn Glu Thr  Cys Ser Gly 
    1085                 1090                 1095             


Lys Ile  His Thr Pro Ser Leu  His Val Asn Gly Ser  Leu Ile Leu 
    1100                 1105                 1110             


Pro Ile  Gly Ser Ile Lys Pro  Leu Asp Phe Ser Leu  Leu Asn Val 
    1115                 1120                 1125             


Gln Asp  Gln Glu Gly Arg Val  Glu Asp Leu Leu Phe  His Val Val 
    1130                 1135                 1140             


Ser Thr  Pro Thr Asn Gly Gln  Leu Val Leu Ser Arg  Asn Gly Lys 
    1145                 1150                 1155             


Glu Val  Gln Leu Asp Lys Ala  Gly Arg Phe Ser Trp  Lys Asp Val 
    1160                 1165                 1170             


Asn Glu  Lys Lys Val Arg Phe  Val His Ser Lys Glu  Lys Leu Arg 
    1175                 1180                 1185             


Lys Gly  Tyr Leu Phe Leu Lys  Ile Ser Asp Gln Gln  Phe Phe Ser 
    1190                 1195                 1200             


Glu Pro  Gln Leu Ile Asn Ile  Gln Ala Phe Ser Thr  Gln Ala Pro 
    1205                 1210                 1215             


Tyr Val  Leu Arg Asn Glu Val  Leu His Ile Ser Arg  Gly Glu Arg 
    1220                 1225                 1230             


Ala Thr  Ile Thr Thr Gln Met  Leu Asp Ile Arg Asp  Asp Asp Asn 
    1235                 1240                 1245             


Pro Gln  Asp Val Val Ile Glu  Ile Ile Asp Pro Pro  Leu His Gly 
    1250                 1255                 1260             


Gln Leu  Leu Gln Thr Leu Gln  Ser Pro Ala Thr Pro  Ile Tyr Gln 
    1265                 1270                 1275             


Phe Gln  Leu Asp Glu Leu Ser  Arg Gly Leu Leu His  Tyr Ala His 
    1280                 1285                 1290             


Asp Gly  Ser Asp Ser Thr Ser  Asp Val Ala Val Leu  Gln Ala Asn 
    1295                 1300                 1305             


Asp Gly  His Ser Phe His Asn  Ile Leu Phe Gln Val  Lys Thr Val 
    1310                 1315                 1320             


Pro Gln  Asn Asp Arg Gly Leu  Gln Leu Val Ala Asn  Ser Met Val 
    1325                 1330                 1335             


Trp Val  Pro Glu Gly Gly Met  Leu Gln Ile Thr Asn  Arg Ile Leu 
    1340                 1345                 1350             


Gln Ala  Glu Ala Pro Gly Ala  Ser Ala Glu Glu Ile  Ile Tyr Lys 
    1355                 1360                 1365             


Ile Thr  Gln Asp Tyr Pro Gln  Phe Gly Glu Val Val  Leu Leu Val 
    1370                 1375                 1380             


Asn Met  Pro Ala Asp Ser Pro  Ala Asp Glu Gly Gln  His Leu Pro 
    1385                 1390                 1395             


Asp Gly  Arg Thr Ala Thr Pro  Thr Ser Thr Phe Thr  Gln Gln Asp 
    1400                 1405                 1410             


Ile Asn  Glu Gly Ile Val Trp  Tyr Arg His Ser Gly  Ala Pro Ala 
    1415                 1420                 1425             


Gln Ser  Asp Ser Phe Arg Phe  Glu Val Ser Ser Ala  Ser Asn Ala 
    1430                 1435                 1440             


Gln Thr  Arg Leu Glu Ser His  Met Phe Asn Ile Ala  Ile Leu Pro 
    1445                 1450                 1455             


Gln Thr  Pro Glu Ala Pro Lys  Val Ser Leu Glu Ala  Ser Leu His 
    1460                 1465                 1470             


Met Thr  Ala Arg Glu Asp Gly  Leu Thr Val Ile Gln  Pro His Ser 
    1475                 1480                 1485             


Leu Ser  Phe Ile Asn Ser Glu  Lys Pro Ser Gly Lys  Ile Val Tyr 
    1490                 1495                 1500             


Asn Ile  Thr Leu Pro Leu His  Pro Asn Gln Gly Ile  Ile Glu His 
    1505                 1510                 1515             


Arg Asp  His Pro His Ser Pro  Ile Arg Tyr Phe Thr  Gln Glu Asp 
    1520                 1525                 1530             


Ile Asn  Gln Gly Lys Val Met  Tyr Arg Pro Pro Pro  Ala Ala Pro 
    1535                 1540                 1545             


His Leu  Gln Glu Leu Met Ala  Phe Ser Phe Ala Gly  Leu Pro Glu 
    1550                 1555                 1560             


Ser Val  Lys Phe His Phe Thr  Val Ser Asp Gly Glu  His Thr Ser 
    1565                 1570                 1575             


Pro Glu  Met Val Leu Thr Ile  His Leu Leu Pro Ser  Asp Gln Gln 
    1580                 1585                 1590             


Leu Pro  Val Phe Gln Val Thr  Ala Pro Arg Leu Ala  Val Ser Pro 
    1595                 1600                 1605             


Gly Gly  Ser Thr Ser Val Gly  Leu Gln Val Val Val  Arg Asp Ala 
    1610                 1615                 1620             


Glu Thr  Ala Pro Lys Glu Leu  Phe Phe Glu Leu Arg  Arg Pro Pro 
    1625                 1630                 1635             


Gln His  Gly Val Leu Leu Lys  His Thr Ala Glu Phe  Arg Arg Pro 
    1640                 1645                 1650             


Met Ala  Thr Gly Asp Thr Phe  Thr Tyr Glu Asp Val  Glu Lys Asn 
    1655                 1660                 1665             


Ala Leu  Gln Tyr Ile His Asp  Gly Ser Ser Thr Arg  Glu Asp Ser 
    1670                 1675                 1680             


Met Glu  Ile Ser Val Thr Asp  Gly Leu Thr Val Thr  Met Leu Glu 
    1685                 1690                 1695             


Val Arg  Val Glu Val Ser Leu  Ser Glu Asp Arg Gly  Pro Arg Leu 
    1700                 1705                 1710             


Ala Ala  Gly Ser Ser Leu Ser  Ile Thr Val Ala Ser  Lys Ser Thr 
    1715                 1720                 1725             


Ala Ile  Ile Thr Arg Ser His  Leu Ala Tyr Val Asp  Asp Ser Ser 
    1730                 1735                 1740             


Pro Asp  Pro Glu Ile Trp Ile  Gln Leu Asn Tyr Leu  Pro Ser Tyr 
    1745                 1750                 1755             


Gly Thr  Leu Leu Arg Ile Ser  Gly Ser Glu Val Glu  Glu Leu Ser 
    1760                 1765                 1770             


Glu Val  Ser Asn Phe Thr Met  Glu Asp Ile Asn Asn  Lys Lys Ile 
    1775                 1780                 1785             


Arg Tyr  Ser Ala Val Phe Glu  Thr Asp Gly His Leu  Val Thr Asp 
    1790                 1795                 1800             


Ser Phe  Tyr Phe Ser Val Ser  Asp Met Asp His Asn  His Leu Asp 
    1805                 1810                 1815             


Asn Gln  Ile Phe Thr Ile Met  Ile Thr Pro Ala Glu  Asn Pro Pro 
    1820                 1825                 1830             


Pro Val  Ile Ala Phe Ala Asp  Leu Ile Thr Val Asp  Glu Gly Gly 
    1835                 1840                 1845             


Arg Ala  Pro Leu Ser Phe His  His Phe Phe Ala Thr  Asp Asp Asp 
    1850                 1855                 1860             


Asp Asn  Leu Gln Arg Asp Ala  Ile Ile Lys Leu Ser  Ala Leu Pro 
    1865                 1870                 1875             


Lys Tyr  Gly Cys Ile Glu Asn  Thr Gly Thr Gly Asp  Arg Phe Gly 
    1880                 1885                 1890             


Pro Glu  Thr Ala Ser Asp Leu  Glu Ala Ser Phe Pro  Ile Gln Asp 
    1895                 1900                 1905             


Val Leu  Glu Asn Tyr Ile Tyr  Tyr Phe Gln Ser Val  His Glu Ser 
    1910                 1915                 1920             


Ile Glu  Pro Thr His Asp Ile  Phe Ser Phe Tyr Val  Ser Asp Gly 
    1925                 1930                 1935             


Thr Ser  Arg Ser Glu Ile His  Ser Ile Asn Ile Thr  Ile Glu Val 
    1940                 1945                 1950             


Lys Thr  Leu Glu Val Gly Lys  Val Glu Pro Leu Thr  Thr Ile Phe 
    1955                 1960                 1965             


His Thr  Ile Arg Glu Leu Ser  Leu 
    1970                 1975     


<210>  5547
<211>  4012
<212>  PRT
<213>  Homo Sapiens

<400>  5547

Met Gly Val Leu Lys Val Trp Leu Gly Leu Ala Leu Ala Leu Ala Glu 
1               5                   10                  15      


Phe Ala Val Leu Pro His His Ser Glu Gly Ala Cys Val Tyr Gln Asp 
            20                  25                  30          


Ser Leu Leu Ala Asp Ala Thr Ile Trp Lys Pro Asp Ser Cys Gln Ser 
        35                  40                  45              


Cys Arg Cys His Gly Asp Ile Val Ile Cys Lys Pro Ala Val Cys Arg 
    50                  55                  60                  


Asn Pro Gln Cys Ala Phe Glu Lys Gly Glu Val Leu Gln Ile Ala Ala 
65                  70                  75                  80  


Asn Gln Cys Cys Pro Glu Cys Val Leu Arg Thr Pro Gly Ser Cys His 
                85                  90                  95      


His Glu Lys Lys Ile His Glu His Gly Thr Glu Trp Ala Ser Ser Pro 
            100                 105                 110         


Cys Ser Val Cys Ser Cys Asn His Gly Glu Val Arg Cys Thr Pro Gln 
        115                 120                 125             


Pro Cys Pro Pro Leu Ser Cys Gly His Gln Glu Leu Ala Phe Ile Pro 
    130                 135                 140                 


Glu Gly Ser Cys Cys Pro Val Cys Val Gly Leu Gly Lys Pro Cys Ser 
145                 150                 155                 160 


Tyr Glu Gly His Val Phe Gln Asp Gly Glu Asp Trp Arg Leu Ser Arg 
                165                 170                 175     


Cys Ala Lys Cys Leu Cys Arg Asn Gly Val Ala Gln Cys Phe Thr Ala 
            180                 185                 190         


Gln Cys Gln Pro Leu Phe Cys Asn Gln Asp Glu Thr Val Val Arg Val 
        195                 200                 205             


Pro Gly Lys Cys Cys Pro Gln Cys Ser Ala Arg Ser Cys Ser Ala Ala 
    210                 215                 220                 


Gly Gln Val Tyr Glu His Gly Glu Gln Trp Ser Glu Asn Ala Cys Thr 
225                 230                 235                 240 


Thr Cys Ile Cys Asp Arg Gly Glu Val Arg Cys His Lys Gln Ala Cys 
                245                 250                 255     


Leu Pro Leu Arg Cys Gly Lys Gly Gln Ser Arg Ala Arg Arg His Gly 
            260                 265                 270         


Gln Cys Cys Glu Glu Cys Val Ser Pro Ala Gly Ser Cys Ser Tyr Asp 
        275                 280                 285             


Gly Val Val Arg Tyr Gln Asp Glu Met Trp Lys Gly Ser Ala Cys Glu 
    290                 295                 300                 


Phe Cys Met Cys Asp His Gly Gln Val Thr Cys Gln Thr Gly Glu Cys 
305                 310                 315                 320 


Ala Lys Val Glu Cys Ala Arg Asp Glu Glu Leu Ile His Leu Asp Gly 
                325                 330                 335     


Lys Cys Cys Pro Glu Cys Ile Ser Arg Asn Gly Tyr Cys Val Tyr Glu 
            340                 345                 350         


Glu Thr Gly Glu Phe Met Ser Ser Asn Ala Ser Glu Val Lys Arg Ile 
        355                 360                 365             


Pro Glu Gly Glu Lys Trp Glu Asp Gly Pro Cys Lys Val Cys Glu Cys 
    370                 375                 380                 


Arg Gly Ala Gln Val Thr Cys Tyr Glu Pro Ser Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Val Gly Thr Leu Ala Leu Glu Val Lys Gly Gln Cys Cys Pro Asp Cys 
                405                 410                 415     


Thr Ser Val His Cys His Pro Asp Cys Leu Thr Cys Ser Gln Ser Pro 
            420                 425                 430         


Asp His Cys Asp Leu Cys Gln Asp Pro Thr Lys Leu Leu Gln Asn Gly 
        435                 440                 445             


Trp Cys Val His Ser Cys Gly Leu Gly Phe Tyr Gln Ala Gly Ser Leu 
    450                 455                 460                 


Cys Leu Ala Cys Gln Pro Gln Cys Ser Thr Cys Thr Ser Gly Leu Glu 
465                 470                 475                 480 


Cys Ser Ser Cys Gln Pro Pro Leu Leu Met Arg His Gly Gln Cys Val 
                485                 490                 495     


Pro Thr Cys Gly Asp Gly Phe Tyr Gln Asp Arg His Ser Cys Ala Val 
            500                 505                 510         


Cys His Glu Ser Cys Ala Gly Cys Trp Gly Pro Thr Glu Lys His Cys 
        515                 520                 525             


Leu Ala Cys Arg Asp Pro Leu His Val Leu Arg Asp Gly Gly Cys Glu 
    530                 535                 540                 


Ser Ser Cys Gly Lys Gly Phe Tyr Asn Arg Gln Gly Thr Cys Ser Ala 
545                 550                 555                 560 


Cys Asp Gln Ser Cys Asp Ser Cys Gly Pro Ser Ser Pro Arg Cys Leu 
                565                 570                 575     


Thr Cys Thr Glu Lys Thr Val Leu His Asp Gly Lys Cys Met Ser Glu 
            580                 585                 590         


Cys Pro Gly Gly Tyr Tyr Ala Asp Ala Thr Gly Arg Cys Lys Val Cys 
        595                 600                 605             


His Asn Ser Cys Ala Ser Cys Ser Gly Pro Thr Pro Ser His Cys Thr 
    610                 615                 620                 


Ala Cys Ser Pro Pro Lys Ala Leu Arg Gln Gly His Cys Leu Pro Arg 
625                 630                 635                 640 


Cys Gly Glu Gly Phe Tyr Ser Asp His Gly Val Cys Lys Ala Cys His 
                645                 650                 655     


Ser Ser Cys Leu Ala Cys Met Gly Pro Ala Pro Ser His Cys Thr Gly 
            660                 665                 670         


Cys Lys Lys Pro Glu Glu Gly Leu Gln Val Glu Gln Leu Ser Asp Val 
        675                 680                 685             


Gly Ile Pro Ser Gly Glu Cys Leu Ala Gln Cys Arg Ala His Phe Tyr 
    690                 695                 700                 


Leu Glu Ser Thr Gly Ile Cys Glu Ala Cys His Gln Ser Cys Phe Arg 
705                 710                 715                 720 


Cys Ala Gly Lys Ser Pro His Asn Cys Thr Asp Cys Gly Pro Ser His 
                725                 730                 735     


Val Leu Leu Asp Gly Gln Cys Leu Ser Gln Cys Pro Asp Gly Tyr Phe 
            740                 745                 750         


His Gln Glu Gly Ser Cys Thr Glu Cys His Pro Thr Cys Arg Gln Cys 
        755                 760                 765             


His Gly Pro Leu Glu Ser Asp Cys Ile Ser Cys Tyr Pro His Ile Ser 
    770                 775                 780                 


Leu Thr Asn Gly Asn Cys Arg Thr Ser Cys Arg Glu Glu Gln Phe Leu 
785                 790                 795                 800 


Asn Leu Val Gly Tyr Cys Ala Asp Cys His His Leu Cys Gln His Cys 
                805                 810                 815     


Ala Ala Asp Leu His Asn Thr Gly Ser Ile Cys Leu Arg Cys Gln Asn 
            820                 825                 830         


Ala His Tyr Leu Leu Leu Gly Asp His Cys Val Pro Asp Cys Pro Ser 
        835                 840                 845             


Gly Tyr Tyr Ala Glu Arg Gly Ala Cys Lys Lys Cys His Ser Ser Cys 
    850                 855                 860                 


Arg Thr Cys Gln Gly Arg Gly Pro Phe Ser Cys Ser Ser Cys Asp Thr 
865                 870                 875                 880 


Asn Leu Val Leu Ser His Thr Gly Thr Cys Ser Thr Thr Cys Phe Pro 
                885                 890                 895     


Gly His Tyr Leu Asp Asp Asn His Val Cys Gln Pro Cys Asn Thr His 
            900                 905                 910         


Cys Gly Ser Cys Asp Ser Gln Ala Ser Cys Thr Ser Cys Arg Asp Pro 
        915                 920                 925             


Asn Lys Val Leu Leu Phe Gly Glu Cys Gln Tyr Glu Ser Cys Ala Pro 
    930                 935                 940                 


Gln Tyr Tyr Leu Asp Phe Ser Thr Asn Thr Cys Lys Glu Cys Asp Trp 
945                 950                 955                 960 


Ser Cys Ser Ala Cys Ser Gly Pro Leu Lys Thr Asp Cys Leu Gln Cys 
                965                 970                 975     


Met Asp Gly Tyr Val Leu Gln Asp Gly Ala Cys Val Glu Gln Cys Leu 
            980                 985                 990         


Ser Ser Phe Tyr Gln Asp Ser Gly  Leu Cys Lys Asn Cys  Asp Ser Tyr 
        995                 1000                 1005             


Cys Leu  Gln Cys Gln Gly Pro  His Glu Cys Thr Arg  Cys Lys Gly 
    1010                 1015                 1020             


Pro Phe  Leu Leu Leu Glu Ala  Gln Cys Val Gln Glu  Cys Gly Lys 
    1025                 1030                 1035             


Gly Tyr  Phe Ala Asp His Ala  Lys His Lys Cys Thr  Ala Cys Pro 
    1040                 1045                 1050             


Gln Gly  Cys Leu Gln Cys Ser  His Arg Asp Arg Cys  His Leu Cys 
    1055                 1060                 1065             


Asp His  Gly Phe Phe Leu Lys  Ser Gly Leu Cys Val  Tyr Asn Cys 
    1070                 1075                 1080             


Val Pro  Gly Phe Ser Val His  Thr Ser Asn Glu Thr  Cys Ser Gly 
    1085                 1090                 1095             


Lys Ile  His Thr Pro Ser Leu  His Val Asn Gly Ser  Leu Ile Leu 
    1100                 1105                 1110             


Pro Ile  Gly Ser Ile Lys Pro  Leu Asp Phe Ser Leu  Leu Asn Val 
    1115                 1120                 1125             


Gln Asp  Gln Glu Gly Arg Val  Glu Asp Leu Leu Phe  His Val Val 
    1130                 1135                 1140             


Ser Thr  Pro Thr Asn Gly Gln  Leu Val Leu Ser Arg  Asn Gly Lys 
    1145                 1150                 1155             


Glu Val  Gln Leu Asp Lys Ala  Gly Arg Phe Ser Trp  Lys Asp Val 
    1160                 1165                 1170             


Asn Glu  Lys Lys Val Arg Phe  Val His Ser Lys Glu  Lys Leu Arg 
    1175                 1180                 1185             


Lys Gly  Tyr Leu Phe Leu Lys  Ile Ser Asp Gln Gln  Phe Phe Ser 
    1190                 1195                 1200             


Glu Pro  Gln Leu Ile Asn Ile  Gln Ala Phe Ser Thr  Gln Ala Pro 
    1205                 1210                 1215             


Tyr Val  Leu Arg Asn Glu Val  Leu His Ile Ser Arg  Gly Glu Arg 
    1220                 1225                 1230             


Ala Thr  Ile Thr Thr Gln Met  Leu Asp Ile Arg Asp  Asp Asp Asn 
    1235                 1240                 1245             


Pro Gln  Asp Val Val Ile Glu  Ile Ile Asp Pro Pro  Leu His Gly 
    1250                 1255                 1260             


Gln Leu  Leu Gln Thr Leu Gln  Ser Pro Ala Thr Pro  Ile Tyr Gln 
    1265                 1270                 1275             


Phe Gln  Leu Asp Glu Leu Ser  Arg Gly Leu Leu His  Tyr Ala His 
    1280                 1285                 1290             


Asp Gly  Ser Asp Ser Thr Ser  Asp Val Ala Val Leu  Gln Ala Asn 
    1295                 1300                 1305             


Asp Gly  His Ser Phe His Asn  Ile Leu Phe Gln Val  Lys Thr Val 
    1310                 1315                 1320             


Pro Gln  Asn Asp Arg Gly Leu  Gln Leu Val Ala Asn  Ser Met Val 
    1325                 1330                 1335             


Trp Val  Pro Glu Gly Gly Met  Leu Gln Ile Thr Asn  Arg Ile Leu 
    1340                 1345                 1350             


Gln Ala  Glu Ala Pro Gly Ala  Ser Ala Glu Glu Ile  Ile Tyr Lys 
    1355                 1360                 1365             


Ile Thr  Gln Asp Tyr Pro Gln  Phe Gly Glu Val Val  Leu Leu Val 
    1370                 1375                 1380             


Asn Met  Pro Ala Asp Ser Pro  Ala Asp Glu Gly Gln  His Leu Pro 
    1385                 1390                 1395             


Asp Gly  Arg Thr Ala Thr Pro  Thr Ser Thr Phe Thr  Gln Gln Asp 
    1400                 1405                 1410             


Ile Asn  Glu Gly Ile Val Trp  Tyr Arg His Ser Gly  Ala Pro Ala 
    1415                 1420                 1425             


Gln Ser  Asp Ser Phe Arg Phe  Glu Val Ser Ser Ala  Ser Asn Ala 
    1430                 1435                 1440             


Gln Thr  Arg Leu Glu Ser His  Met Phe Asn Ile Ala  Ile Leu Pro 
    1445                 1450                 1455             


Gln Thr  Pro Glu Ala Pro Lys  Val Ser Leu Glu Ala  Ser Leu His 
    1460                 1465                 1470             


Met Thr  Ala Arg Glu Asp Gly  Leu Thr Val Ile Gln  Pro His Ser 
    1475                 1480                 1485             


Leu Ser  Phe Ile Asn Ser Glu  Lys Pro Ser Gly Lys  Ile Val Tyr 
    1490                 1495                 1500             


Asn Ile  Thr Leu Pro Leu His  Pro Asn Gln Gly Ile  Ile Glu His 
    1505                 1510                 1515             


Arg Asp  His Pro His Ser Pro  Ile Arg Tyr Phe Thr  Gln Glu Asp 
    1520                 1525                 1530             


Ile Asn  Gln Gly Lys Val Met  Tyr Arg Pro Pro Pro  Ala Ala Pro 
    1535                 1540                 1545             


His Leu  Gln Glu Leu Met Ala  Phe Ser Phe Ala Gly  Leu Pro Glu 
    1550                 1555                 1560             


Ser Val  Lys Phe His Phe Thr  Val Ser Asp Gly Glu  His Thr Ser 
    1565                 1570                 1575             


Pro Glu  Met Val Leu Thr Ile  His Leu Leu Pro Ser  Asp Gln Gln 
    1580                 1585                 1590             


Leu Pro  Val Phe Gln Val Thr  Ala Pro Arg Leu Ala  Val Ser Pro 
    1595                 1600                 1605             


Gly Gly  Ser Thr Ser Val Gly  Leu Gln Val Val Val  Arg Asp Ala 
    1610                 1615                 1620             


Glu Thr  Ala Pro Lys Glu Leu  Phe Phe Glu Leu Arg  Arg Pro Pro 
    1625                 1630                 1635             


Gln His  Gly Val Leu Leu Lys  His Thr Ala Glu Phe  Arg Arg Pro 
    1640                 1645                 1650             


Met Ala  Thr Gly Asp Thr Phe  Thr Tyr Glu Asp Val  Glu Lys Asn 
    1655                 1660                 1665             


Ala Leu  Gln Tyr Ile His Asp  Gly Ser Ser Thr Arg  Glu Asp Ser 
    1670                 1675                 1680             


Met Glu  Ile Ser Val Thr Asp  Gly Leu Thr Val Thr  Met Leu Glu 
    1685                 1690                 1695             


Val Arg  Val Glu Val Ser Leu  Ser Glu Asp Arg Gly  Pro Arg Leu 
    1700                 1705                 1710             


Ala Ala  Gly Ser Ser Leu Ser  Ile Thr Val Ala Ser  Lys Ser Thr 
    1715                 1720                 1725             


Ala Ile  Ile Thr Arg Ser His  Leu Ala Tyr Val Asp  Asp Ser Ser 
    1730                 1735                 1740             


Pro Asp  Pro Glu Ile Trp Ile  Gln Leu Asn Tyr Leu  Pro Ser Tyr 
    1745                 1750                 1755             


Gly Thr  Leu Leu Arg Ile Ser  Gly Ser Glu Val Glu  Glu Leu Ser 
    1760                 1765                 1770             


Glu Val  Ser Asn Phe Thr Met  Glu Asp Ile Asn Asn  Lys Lys Ile 
    1775                 1780                 1785             


Arg Tyr  Ser Ala Val Phe Glu  Thr Asp Gly His Leu  Val Thr Asp 
    1790                 1795                 1800             


Ser Phe  Tyr Phe Ser Val Ser  Asp Met Asp His Asn  His Leu Asp 
    1805                 1810                 1815             


Asn Gln  Ile Phe Thr Ile Met  Ile Thr Pro Ala Glu  Asn Pro Pro 
    1820                 1825                 1830             


Pro Val  Ile Ala Phe Ala Asp  Leu Ile Thr Val Asp  Glu Gly Gly 
    1835                 1840                 1845             


Arg Ala  Pro Leu Ser Phe His  His Phe Phe Ala Thr  Asp Asp Asp 
    1850                 1855                 1860             


Asp Asn  Leu Gln Arg Asp Ala  Ile Ile Lys Leu Ser  Ala Leu Pro 
    1865                 1870                 1875             


Lys Tyr  Gly Cys Ile Glu Asn  Thr Gly Thr Gly Asp  Arg Phe Gly 
    1880                 1885                 1890             


Pro Glu  Thr Ala Ser Asp Leu  Glu Ala Ser Phe Pro  Ile Gln Asp 
    1895                 1900                 1905             


Val Leu  Glu Asn Tyr Ile Tyr  Tyr Phe Gln Ser Val  His Glu Ser 
    1910                 1915                 1920             


Ile Glu  Pro Thr His Asp Ile  Phe Ser Phe Tyr Val  Ser Asp Gly 
    1925                 1930                 1935             


Thr Ser  Arg Ser Glu Ile His  Ser Ile Asn Ile Thr  Ile Glu Arg 
    1940                 1945                 1950             


Lys Asn  Asp Glu Pro Pro Arg  Met Thr Leu Gln Pro  Leu Arg Val 
    1955                 1960                 1965             


Gln Leu  Ser Ser Gly Val Val  Ile Ser Asn Ser Ser  Leu Ser Leu 
    1970                 1975                 1980             


Gln Asp  Leu Asp Thr Pro Asp  Asn Glu Leu Ile Phe  Val Leu Thr 
    1985                 1990                 1995             


Lys Lys  Pro Asp His Gly His  Val Leu Trp Arg Gln  Thr Ala Ser 
    2000                 2005                 2010             


Glu Pro  Leu Glu Asn Gly Arg  Val Leu Val Gln Gly  Ser Thr Phe 
    2015                 2020                 2025             


Thr Tyr  Gln Asp Ile Leu Ala  Gly Leu Val Gly Tyr  Val Pro Ser 
    2030                 2035                 2040             


Val Pro  Gly Met Val Val Asp  Glu Phe Gln Phe Ser  Leu Thr Asp 
    2045                 2050                 2055             


Gly Leu  His Val Asp Thr Gly  Arg Met Lys Ile Tyr  Thr Glu Leu 
    2060                 2065                 2070             


Pro Ala  Ser Asp Thr Pro His  Leu Ala Ile Asn Gln  Gly Leu Gln 
    2075                 2080                 2085             


Leu Ser  Ala Gly Ser Val Ala  Arg Ile Thr Glu Gln  His Leu Lys 
    2090                 2095                 2100             


Val Thr  Asp Ile Asp Ser Asp  Asp His Gln Val Met  Tyr Ile Met 
    2105                 2110                 2115             


Lys Glu  Asp Pro Gly Ala Gly  Arg Leu Gln Met Met  Lys His Gly 
    2120                 2125                 2130             


Asn Leu  Glu Gln Ile Ser Ile  Lys Gly Pro Ile Arg  Ser Phe Thr 
    2135                 2140                 2145             


Gln Ala  Asp Ile Ser Gln Gly  His Val Glu Tyr Ser  His Gly Thr 
    2150                 2155                 2160             


Gly Glu  Pro Gly Gly Ser Phe  Ala Phe Lys Phe Asp  Val Val Asp 
    2165                 2170                 2175             


Gly Glu  Gly Asn Arg Leu Ile  Asp Lys Ser Phe Ser  Ile Ser Ile 
    2180                 2185                 2190             


Leu Glu  Asp Lys Ser Pro Pro  Val Ile Thr Thr Asn  Lys Gly Leu 
    2195                 2200                 2205             


Val Leu  Asp Glu Asn Ser Val  Lys Lys Ile Thr Thr  Leu Gln Leu 
    2210                 2215                 2220             


Ser Ala  Thr Asp Gln Asp Ser  Gly Pro Thr Glu Leu  Ile Tyr Arg 
    2225                 2230                 2235             


Ile Thr  Arg Gln Pro Gln Leu  Gly His Leu Glu His  Ala Ala Ser 
    2240                 2245                 2250             


Pro Gly  Ile Gln Ile Ser Ser  Phe Thr Gln Ala Asp  Leu Thr Ser 
    2255                 2260                 2265             


Arg Asn  Val Gln Tyr Val His  Ser Ser Glu Ala Glu  Lys His Ser 
    2270                 2275                 2280             


Asp Ala  Phe Ser Phe Thr Leu  Ser Asp Gly Val Ser  Glu Val Thr 
    2285                 2290                 2295             


Gln Thr  Phe His Ile Thr Leu  His Pro Val Asp Asp  Ser Leu Pro 
    2300                 2305                 2310             


Val Val  Gln Asn Leu Gly Met  Arg Val Gln Glu Gly  Met Arg Lys 
    2315                 2320                 2325             


Thr Ile  Thr Glu Phe Glu Leu  Lys Ala Val Asp Ala  Asp Thr Glu 
    2330                 2335                 2340             


Ala Glu  Ser Val Thr Phe Thr  Ile Val Gln Pro Pro  Arg His Gly 
    2345                 2350                 2355             


Thr Ile  Glu Arg Thr Ser Asn  Gly Gln His Phe His  Leu Thr Ser 
    2360                 2365                 2370             


Thr Phe  Thr Met Lys Asp Ile  Tyr Gln Asn Arg Val  Ser Tyr Ser 
    2375                 2380                 2385             


His Asp  Gly Ser Asn Ser Leu  Lys Asp Arg Phe Thr  Phe Thr Val 
    2390                 2395                 2400             


Ser Asp  Gly Thr Asn Pro Phe  Phe Ile Ile Glu Glu  Gly Gly Lys 
    2405                 2410                 2415             


Glu Ile  Met Thr Ala Ala Pro  Gln Pro Phe Arg Val  Asp Ile Leu 
    2420                 2425                 2430             


Pro Val  Asp Asp Gly Thr Pro  Arg Ile Val Thr Asn  Leu Gly Leu 
    2435                 2440                 2445             


Gln Trp  Leu Glu Tyr Met Asp  Gly Lys Ala Thr Asn  Leu Ile Thr 
    2450                 2455                 2460             


Lys Lys  Glu Leu Leu Thr Met  Asp Pro Asp Thr Glu  Asp Ala Gln 
    2465                 2470                 2475             


Leu Val  Tyr Glu Ile Thr Thr  Gly Pro Lys His Gly  Phe Val Glu 
    2480                 2485                 2490             


Asn Lys  Leu Gln Pro Gly Arg  Ala Ala Ala Thr Phe  Thr Gln Glu 
    2495                 2500                 2505             


Asp Val  Asn Leu Gly Leu Ile  Arg Tyr Val Leu His  Lys Glu Lys 
    2510                 2515                 2520             


Ile Arg  Glu Met Met Asp Ser  Phe Gln Phe Leu Val  Lys Asp Ser 
    2525                 2530                 2535             


Lys Pro  Asn Val Val Ser Asp  Asn Val Phe His Ile  Gln Trp Ser 
    2540                 2545                 2550             


Leu Ile  Ser Phe Lys Tyr Thr  Ser Tyr Asn Val Ser  Glu Lys Ala 
    2555                 2560                 2565             


Gly Ser  Val Ser Val Thr Val  Gln Arg Thr Gly Asn  Leu Asn Gln 
    2570                 2575                 2580             


Tyr Ala  Ile Val Leu Cys Arg  Thr Glu Gln Gly Thr  Ala Ser Ser 
    2585                 2590                 2595             


Ser Ser  Arg Val Ser Ser Gln  Pro Gly Gln Gln Asp  Tyr Val Glu 
    2600                 2605                 2610             


Tyr Ala  Gly Gln Val Gln Phe  Asp Glu Arg Glu Asp  Thr Lys Ser 
    2615                 2620                 2625             


Cys Thr  Ile Val Ile Asn Asp  Asp Asp Val Phe Glu  Asn Val Glu 
    2630                 2635                 2640             


Ser Phe  Thr Val Glu Leu Ser  Met Pro Ala Tyr Ala  Leu Leu Gly 
    2645                 2650                 2655             


Glu Phe  Thr Gln Ala Lys Val  Ile Ile Asn Asp Thr  Glu Asp Glu 
    2660                 2665                 2670             


Pro Thr  Leu Glu Phe Asp Lys  Lys Ile Tyr Trp Val  Asn Glu Ser 
    2675                 2680                 2685             


Ala Gly  Phe Leu Phe Ala Pro  Ile Glu Arg Lys Gly  Asp Ala Ser 
    2690                 2695                 2700             


Ser Ile  Val Ser Ala Ile Cys  Tyr Thr Val Pro Lys  Ser Ala Met 
    2705                 2710                 2715             


Gly Ser  Ser Leu Tyr Ala Leu  Glu Ser Gly Ser Asp  Phe Lys Ser 
    2720                 2725                 2730             


Arg Gly  Met Ser Ala Ala Ser  Arg Val Ile Phe Gly  Pro Gly Val 
    2735                 2740                 2745             


Thr Met  Ser Thr Cys Asp Val  Met Leu Ile Asp Asp  Ser Glu Tyr 
    2750                 2755                 2760             


Glu Glu  Glu Glu Glu Phe Glu  Ile Ala Leu Ala Asp  Ala Ser Asp 
    2765                 2770                 2775             


Asn Ala  Arg Ile Gly Arg Val  Ala Thr Ala Lys Val  Leu Ile Ser 
    2780                 2785                 2790             


Gly Pro  Asn Asp Ala Ser Thr  Val Ser Leu Gly Asn  Thr Ala Phe 
    2795                 2800                 2805             


Thr Val  Ser Glu Asp Ala Gly  Thr Val Lys Ile Pro  Val Ile Arg 
    2810                 2815                 2820             


His Gly  Thr Asp Leu Ser Thr  Phe Ala Ser Val Trp  Cys Ala Thr 
    2825                 2830                 2835             


Arg Pro  Ser Asp Pro Ala Ser  Ala Thr Pro Gly Val  Asp Tyr Val 
    2840                 2845                 2850             


Pro Ser  Ser Arg Lys Val Glu  Phe Gly Pro Gly Val  Ile Glu Gln 
    2855                 2860                 2865             


Tyr Cys  Thr Leu Thr Ile Leu  Asp Asp Thr Gln Tyr  Pro Val Ile 
    2870                 2875                 2880             


Glu Gly  Leu Glu Thr Phe Val  Val Phe Leu Ser Ser  Ala Gln Gly 
    2885                 2890                 2895             


Ala Glu  Leu Thr Lys Pro Phe  Gln Ala Val Ile Ala  Ile Asn Asp 
    2900                 2905                 2910             


Thr Phe  Gln Asp Val Pro Ser  Met Gln Phe Ala Lys  Asp Leu Leu 
    2915                 2920                 2925             


Leu Val  Lys Glu Lys Glu Gly  Val Leu His Val Pro  Ile Thr Arg 
    2930                 2935                 2940             


Ser Gly  Asp Leu Ser Tyr Glu  Ser Ser Val Arg Cys  Tyr Thr Gln 
    2945                 2950                 2955             


Ser His  Ser Ala Gln Val Met  Glu Asp Phe Glu Glu  Arg Gln Asn 
    2960                 2965                 2970             


Ala Asp  Ser Ser Arg Ile Thr  Phe Leu Lys Gly Asp  Lys Val Lys 
    2975                 2980                 2985             


Asn Cys  Thr Val Tyr Ile His  Asp Asp Ser Met Phe  Glu Pro Glu 
    2990                 2995                 3000             


Glu Gln  Phe Arg Val Tyr Leu  Gly Leu Pro Leu Gly  Asn His Trp 
    3005                 3010                 3015             


Ser Gly  Ala Arg Ile Gly Lys  Asn Asn Met Ala Thr  Ile Thr Ile 
    3020                 3025                 3030             


Ser Asn  Asp Glu Asp Ala Pro  Thr Ile Glu Phe Glu  Glu Ala Ala 
    3035                 3040                 3045             


Tyr Gln  Val Arg Glu Pro Ala  Gly Pro Asp Ala Ile  Ala Ile Leu 
    3050                 3055                 3060             


Asn Ile  Lys Val Ile Arg Arg  Gly Asp Gln Asn Arg  Thr Ser Lys 
    3065                 3070                 3075             


Val Arg  Cys Ser Thr Arg Asp  Gly Ser Ala Gln Ser  Gly Val Asp 
    3080                 3085                 3090             


Tyr Tyr  Pro Lys Ser Arg Val  Leu Lys Phe Ser Pro  Gly Val Asp 
    3095                 3100                 3105             


His Ile  Phe Phe Lys Val Glu  Ile Leu Ser Asn Glu  Asp Arg Glu 
    3110                 3115                 3120             


Trp His  Glu Ser Phe Ser Leu  Val Leu Gly Pro Asp  Asp Pro Val 
    3125                 3130                 3135             


Glu Ala  Val Leu Gly Asp Val  Thr Thr Ala Thr Val  Thr Ile Leu 
    3140                 3145                 3150             


Asp Gln  Glu Ala Ala Gly Ser  Leu Ile Leu Pro Ala  Pro Pro Ile 
    3155                 3160                 3165             


Val Val  Thr Leu Ala Asp Tyr  Asp His Val Glu Glu  Val Thr Lys 
    3170                 3175                 3180             


Glu Gly  Val Lys Lys Ser Pro  Ser Pro Gly Tyr Pro  Leu Val Cys 
    3185                 3190                 3195             


Val Thr  Pro Cys Asp Pro His  Phe Pro Arg Tyr Ala  Val Met Lys 
    3200                 3205                 3210             


Glu Arg  Cys Ser Glu Ala Gly  Ile Asn Gln Thr Ser  Val Gln Phe 
    3215                 3220                 3225             


Ser Trp  Glu Val Ala Ala Pro  Thr Asp Gly Asn Gly  Ala Arg Ser 
    3230                 3235                 3240             


Pro Phe  Glu Thr Ile Thr Asp  Asn Thr Pro Phe Thr  Ser Val Asn 
    3245                 3250                 3255             


His Met  Val Leu Asp Ser Ile  Tyr Phe Ser Arg Arg  Phe His Val 
    3260                 3265                 3270             


Arg Cys  Val Ala Lys Ala Val  Asp Lys Val Gly His  Val Gly Thr 
    3275                 3280                 3285             


Pro Leu  Arg Ser Asn Ile Val  Thr Ile Gly Thr Asp  Ser Ala Ile 
    3290                 3295                 3300             


Cys His  Thr Pro Val Val Ala  Gly Thr Ser Arg Gly  Phe Gln Ala 
    3305                 3310                 3315             


Gln Ser  Phe Ile Ala Thr Leu  Lys Tyr Leu Asp Val  Lys His Lys 
    3320                 3325                 3330             


Glu His  Pro Asn Arg Ile His  Ile Ser Val Gln Ile  Pro His Gln 
    3335                 3340                 3345             


Asp Gly  Met Leu Pro Leu Ile  Ser Thr Met Pro Leu  His Asn Leu 
    3350                 3355                 3360             


His Phe  Leu Leu Ser Glu Ser  Ile Tyr Arg His Gln  His Val Cys 
    3365                 3370                 3375             


Ser Asn  Leu Val Thr Thr Tyr  Asp Leu Arg Gly Ile  Ser Glu Ala 
    3380                 3385                 3390             


Gly Phe  Leu Asp Asp Val Val  Tyr Asp Ser Thr Ala  Leu Gly Pro 
    3395                 3400                 3405             


Gly Tyr  Asp Arg Pro Phe Gln  Phe Asp Pro Ser Val  Arg Glu Pro 
    3410                 3415                 3420             


Lys Thr  Ile Gln Leu Tyr Lys  His Leu Asn Leu Lys  Ser Cys Val 
    3425                 3430                 3435             


Trp Thr  Phe Asp Ala Tyr Tyr  Asp Met Thr Glu Leu  Ile Asp Val 
    3440                 3445                 3450             


Cys Gly  Gly Ser Val Thr Ala  Asp Phe Gln Val Arg  Asp Ser Ala 
    3455                 3460                 3465             


Gln Ser  Phe Leu Thr Val His  Val Pro Leu Tyr Val  Ser Tyr Ile 
    3470                 3475                 3480             


Tyr Val  Thr Ala Pro Arg Gly  Trp Ala Ser Leu Glu  His His Thr 
    3485                 3490                 3495             


Glu Met  Glu Phe Ser Phe Phe  Tyr Asp Thr Val Leu  Trp Arg Thr 
    3500                 3505                 3510             


Gly Ile  Gln Thr Asp Ser Val  Leu Ser Ala Arg Leu  Gln Ile Ile 
    3515                 3520                 3525             


Arg Ile  Tyr Ile Arg Glu Asp  Gly Arg Leu Val Ile  Glu Phe Lys 
    3530                 3535                 3540             


Thr His  Ala Lys Phe Arg Gly  Gln Phe Val Met Glu  His His Thr 
    3545                 3550                 3555             


Leu Pro  Glu Val Lys Ser Phe  Val Leu Thr Pro Asp  His Leu Gly 
    3560                 3565                 3570             


Gly Ile  Glu Phe Asp Leu Gln  Leu Leu Trp Ser Ala  Gln Thr Phe 
    3575                 3580                 3585             


Asp Ser  Pro His Gln Leu Trp  Arg Ala Thr Ser Ser  Tyr Asn Arg 
    3590                 3595                 3600             


Lys Asp  Tyr Ser Gly Glu Tyr  Thr Ile Tyr Leu Ile  Pro Cys Thr 
    3605                 3610                 3615             


Val Gln  Pro Thr Gln Pro Trp  Val Asp Pro Gly Glu  Lys Pro Leu 
    3620                 3625                 3630             


Ala Cys  Thr Ala His Ala Pro  Glu Arg Phe Leu Ile  Pro Ile Ala 
    3635                 3640                 3645             


Phe Gln  Gln Thr Asn Arg Pro  Val Pro Val Val Tyr  Ser Leu Asn 
    3650                 3655                 3660             


Thr Glu  Phe Gln Leu Cys Asn  Asn Glu Lys Val Phe  Leu Met Asp 
    3665                 3670                 3675             


Pro Asn  Thr Ser Asp Met Ser  Leu Ala Glu Met Asp  Tyr Lys Gly 
    3680                 3685                 3690             


Ala Phe  Ser Lys Gly Gln Ile  Leu Tyr Gly Arg Val  Leu Trp Asn 
    3695                 3700                 3705             


Pro Glu  Gln Asn Leu Asn Ser  Ala Tyr Lys Leu Gln  Leu Glu Lys 
    3710                 3715                 3720             


Val Tyr  Leu Cys Thr Gly Lys  Asp Gly Tyr Val Pro  Phe Phe Asp 
    3725                 3730                 3735             


Pro Thr  Gly Thr Ile Tyr Asn  Glu Gly Pro Gln Tyr  Gly Cys Ile 
    3740                 3745                 3750             


Gln Pro  Asn Lys His Leu Lys  His Arg Phe Leu Leu  Leu Asp Arg 
    3755                 3760                 3765             


Asn Gln  Pro Glu Val Thr Asp  Lys Tyr Phe His Asp  Val Pro Phe 
    3770                 3775                 3780             


Glu Ala  His Phe Ala Ser Glu  Leu Pro Asp Phe His  Val Val Ser 
    3785                 3790                 3795             


Asn Met  Pro Gly Val Asp Gly  Phe Thr Leu Lys Val  Asp Ala Leu 
    3800                 3805                 3810             


Tyr Lys  Val Glu Ala Gly His  Gln Trp Tyr Leu Gln  Val Ile Tyr 
    3815                 3820                 3825             


Ile Ile  Gly Pro Asp Thr Ile  Ser Gly Pro Arg Val  Gln Arg Ser 
    3830                 3835                 3840             


Leu Thr  Ala Pro Leu Arg Arg  Asn Arg Arg Asp Leu  Val Glu Pro 
    3845                 3850                 3855             


Asp Gly  Gln Leu Ile Leu Asp  Asp Ser Leu Ile Tyr  Asp Asn Glu 
    3860                 3865                 3870             


Gly Asp  Gln Val Lys Asn Gly  Thr Asn Met Lys Ser  Leu Asn Leu 
    3875                 3880                 3885             


Glu Met  Gln Glu Leu Ala Val  Ala Ala Ser Leu Ser  Gln Thr Gly 
    3890                 3895                 3900             


Ala Ser  Ile Gly Ser Ala Leu  Ala Ala Ile Met Leu  Leu Leu Leu 
    3905                 3910                 3915             


Val Phe  Leu Val Ala Cys Phe  Ile Asn Arg Lys Cys  Gln Lys Gln 
    3920                 3925                 3930             


Arg Lys  Lys Lys Pro Ala Glu  Asp Ile Leu Glu Glu  Tyr Pro Leu 
    3935                 3940                 3945             


Asn Thr  Lys Val Glu Val Pro  Lys Arg His Pro Asp  Arg Val Glu 
    3950                 3955                 3960             


Lys Asn  Val Asn Arg His Tyr  Cys Thr Val Arg Asn  Val Asn Ile 
    3965                 3970                 3975             


Leu Ser  Glu Pro Glu Ala Ala  Tyr Thr Phe Lys Gly  Ala Lys Val 
    3980                 3985                 3990             


Lys Arg  Leu Asn Leu Glu Val  Arg Val His Asn Asn  Leu Gln Asp 
    3995                 4000                 4005             


Gly Thr  Glu Val 
    4010         


<210>  5548
<211>  39
<212>  PRT
<213>  Homo Sapiens

<400>  5548

Met Gly Val Leu Lys Val Trp Leu Gly Leu Ala Leu Ala Leu Ala Glu 
1               5                   10                  15      


Phe Ala Val Leu Pro His His Ser Glu Gly Ala Cys Val Tyr Gln Asp 
            20                  25                  30          


Ser Leu Leu Ala Glu Gly Gly 
        35                  


<210>  5549
<211>  652
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5549

Xaa Cys Ser Tyr Glu Gly His Val Phe Gln Asp Gly Glu Asp Trp Arg 
1               5                   10                  15      


Leu Ser Arg Cys Ala Lys Cys Leu Cys Arg Asn Gly Val Ala Gln Cys 
            20                  25                  30          


Phe Thr Ala Gln Cys Gln Pro Leu Phe Cys Asn Gln Asp Glu Thr Val 
        35                  40                  45              


Val Arg Val Pro Gly Lys Cys Cys Pro Gln Cys Ser Ala Arg Ser Cys 
    50                  55                  60                  


Ser Ala Ala Gly Gln Val Tyr Glu His Gly Glu Gln Trp Ser Glu Asn 
65                  70                  75                  80  


Ala Cys Thr Thr Cys Ile Cys Asp Arg Gly Glu Val Arg Cys His Lys 
                85                  90                  95      


Gln Ala Cys Leu Pro Leu Arg Cys Gly Lys Gly Gln Ser Arg Ala Arg 
            100                 105                 110         


Arg His Gly Gln Cys Cys Glu Glu Cys Val Ser Pro Ala Gly Ser Cys 
        115                 120                 125             


Ser Tyr Asp Gly Val Val Arg Tyr Gln Asp Glu Met Trp Lys Gly Ser 
    130                 135                 140                 


Ala Cys Glu Phe Cys Met Cys Asp His Gly Gln Val Thr Cys Gln Thr 
145                 150                 155                 160 


Gly Glu Cys Ala Lys Val Glu Cys Ala Arg Asp Glu Glu Leu Ile His 
                165                 170                 175     


Leu Asp Gly Lys Cys Cys Pro Glu Cys Ile Ser Arg Asn Gly Tyr Cys 
            180                 185                 190         


Val Tyr Glu Glu Thr Gly Glu Phe Met Ser Ser Asn Ala Ser Glu Val 
        195                 200                 205             


Lys Arg Ile Pro Glu Gly Glu Lys Trp Glu Asp Gly Pro Cys Lys Val 
    210                 215                 220                 


Cys Glu Cys Arg Gly Ala Gln Val Thr Cys Tyr Glu Pro Ser Cys Pro 
225                 230                 235                 240 


Pro Cys Pro Val Gly Thr Leu Ala Leu Glu Val Lys Gly Gln Cys Cys 
                245                 250                 255     


Pro Asp Cys Thr Ser Val His Cys His Pro Asp Cys Leu Thr Cys Ser 
            260                 265                 270         


Gln Ser Pro Asp His Cys Asp Leu Cys Gln Asp Pro Thr Lys Leu Leu 
        275                 280                 285             


Gln Asn Gly Trp Cys Val His Ser Cys Gly Leu Gly Phe Tyr Gln Ala 
    290                 295                 300                 


Gly Ser Leu Cys Leu Ala Cys Gln Pro Gln Cys Ser Thr Cys Thr Ser 
305                 310                 315                 320 


Gly Leu Glu Cys Ser Ser Cys Gln Pro Pro Leu Leu Met Arg His Gly 
                325                 330                 335     


Gln Cys Val Pro Thr Cys Gly Asp Gly Phe Tyr Gln Asp Arg His Ser 
            340                 345                 350         


Cys Ala Val Cys His Glu Ser Cys Ala Gly Cys Trp Gly Pro Thr Glu 
        355                 360                 365             


Lys His Cys Leu Ala Cys Arg Asp Pro Leu His Val Leu Arg Asp Gly 
    370                 375                 380                 


Gly Cys Glu Ser Ser Cys Gly Lys Gly Phe Tyr Asn Arg Gln Gly Thr 
385                 390                 395                 400 


Cys Ser Ala Cys Asp Gln Ser Cys Asp Ser Cys Gly Pro Ser Ser Pro 
                405                 410                 415     


Arg Cys Leu Thr Cys Thr Glu Lys Thr Val Leu His Asp Gly Lys Cys 
            420                 425                 430         


Met Ser Glu Cys Pro Gly Gly Tyr Tyr Ala Asp Ala Thr Gly Arg Cys 
        435                 440                 445             


Lys Val Cys His Asn Ser Cys Ala Ser Cys Ser Gly Pro Thr Pro Ser 
    450                 455                 460                 


His Cys Thr Ala Cys Ser Pro Pro Lys Ala Leu Arg Gln Gly His Cys 
465                 470                 475                 480 


Leu Pro Arg Cys Gly Glu Gly Phe Tyr Ser Asp His Gly Val Cys Lys 
                485                 490                 495     


Ala Cys His Ser Ser Cys Leu Ala Cys Met Gly Pro Ala Pro Ser His 
            500                 505                 510         


Cys Thr Gly Cys Lys Lys Pro Glu Glu Gly Leu Gln Val Glu Gln Leu 
        515                 520                 525             


Ser Asp Val Gly Ile Pro Ser Gly Glu Cys Leu Ala Gln Cys Arg Ala 
    530                 535                 540                 


His Phe Tyr Leu Glu Ser Thr Gly Ile Cys Glu Ala Cys His Gln Ser 
545                 550                 555                 560 


Cys Phe Arg Cys Ala Gly Lys Ser Pro His Asn Cys Thr Asp Cys Gly 
                565                 570                 575     


Pro Ser His Val Leu Leu Asp Gly Gln Cys Leu Ser Gln Cys Pro Asp 
            580                 585                 590         


Gly Tyr Phe His Gln Glu Gly Ser Cys Thr Glu Cys His Pro Thr Cys 
        595                 600                 605             


Arg Gln Cys His Gly Pro Leu Glu Ser Asp Cys Ile Ser Cys Tyr Pro 
    610                 615                 620                 


His Ile Ser Leu Thr Asn Gly Asn Cys Arg Thr Ser Cys Arg Glu Glu 
625                 630                 635                 640 


Gln Phe Leu Asn Leu Val Gly Tyr Cys Ala Gly Glu 
                645                 650         


<210>  5550
<211>  666
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5550

Xaa Gly Glu Val Leu Gln Ile Ala Ala Asn Gln Cys Cys Pro Glu Cys 
1               5                   10                  15      


Val Leu Arg Thr Pro Gly Ser Cys His His Glu Lys Lys Ile His Glu 
            20                  25                  30          


His Gly Thr Glu Trp Ala Ser Ser Pro Cys Ser Val Cys Ser Cys Asn 
        35                  40                  45              


His Gly Glu Val Arg Cys Thr Pro Gln Pro Cys Pro Pro Leu Ser Cys 
    50                  55                  60                  


Gly His Gln Glu Leu Ala Phe Ile Pro Glu Gly Ser Cys Cys Pro Val 
65                  70                  75                  80  


Cys Val Gly Leu Gly Lys Pro Cys Ser Tyr Glu Gly His Val Phe Gln 
                85                  90                  95      


Asp Gly Glu Asp Trp Arg Leu Ser Arg Cys Ala Lys Cys Leu Cys Arg 
            100                 105                 110         


Asn Gly Val Ala Gln Cys Phe Thr Ala Gln Cys Gln Pro Leu Phe Cys 
        115                 120                 125             


Asn Gln Asp Glu Thr Val Val Arg Val Pro Gly Lys Cys Cys Pro Gln 
    130                 135                 140                 


Cys Ser Ala Arg Ser Cys Ser Ala Ala Gly Gln Val Tyr Glu His Gly 
145                 150                 155                 160 


Glu Gln Trp Ser Glu Asn Ala Cys Thr Thr Cys Ile Cys Asp Arg Gly 
                165                 170                 175     


Glu Val Arg Cys His Lys Gln Ala Cys Leu Pro Leu Arg Cys Gly Lys 
            180                 185                 190         


Gly Gln Ser Arg Ala Arg Arg His Gly Gln Cys Cys Glu Glu Cys Val 
        195                 200                 205             


Ser Pro Ala Gly Ser Cys Ser Tyr Asp Gly Val Val Arg Tyr Gln Asp 
    210                 215                 220                 


Glu Met Trp Lys Gly Ser Ala Cys Glu Phe Cys Met Cys Asp His Gly 
225                 230                 235                 240 


Gln Val Thr Cys Gln Thr Gly Glu Cys Ala Lys Val Glu Cys Ala Arg 
                245                 250                 255     


Asp Glu Glu Leu Ile His Leu Asp Gly Lys Cys Cys Pro Glu Cys Ile 
            260                 265                 270         


Ser Arg Asn Gly Tyr Cys Val Tyr Glu Glu Thr Gly Glu Phe Met Ser 
        275                 280                 285             


Ser Asn Ala Ser Glu Val Lys Arg Ile Pro Glu Gly Glu Lys Trp Glu 
    290                 295                 300                 


Asp Gly Pro Cys Lys Val Cys Glu Cys Arg Gly Ala Gln Val Thr Cys 
305                 310                 315                 320 


Tyr Glu Pro Ser Cys Pro Pro Cys Pro Val Gly Thr Leu Ala Leu Glu 
                325                 330                 335     


Val Lys Gly Gln Cys Cys Pro Asp Cys Thr Ser Val His Cys His Pro 
            340                 345                 350         


Asp Cys Leu Thr Cys Ser Gln Ser Pro Asp His Cys Asp Leu Cys Gln 
        355                 360                 365             


Asp Pro Thr Lys Leu Leu Gln Asn Gly Trp Cys Val His Ser Cys Gly 
    370                 375                 380                 


Leu Gly Phe Tyr Gln Ala Gly Ser Leu Cys Leu Ala Cys Gln Pro Gln 
385                 390                 395                 400 


Cys Ser Thr Cys Thr Ser Gly Leu Glu Cys Ser Ser Cys Gln Pro Pro 
                405                 410                 415     


Leu Leu Met Arg His Gly Gln Cys Val Pro Thr Cys Gly Asp Gly Phe 
            420                 425                 430         


Tyr Gln Asp Arg His Ser Cys Ala Val Cys His Glu Ser Cys Ala Gly 
        435                 440                 445             


Cys Trp Gly Pro Thr Glu Lys His Cys Leu Ala Cys Arg Asp Pro Leu 
    450                 455                 460                 


His Val Leu Arg Asp Gly Gly Cys Glu Ser Ser Cys Gly Lys Gly Phe 
465                 470                 475                 480 


Tyr Asn Arg Gln Gly Thr Cys Ser Ala Cys Asp Gln Ser Cys Asp Ser 
                485                 490                 495     


Cys Gly Pro Ser Ser Pro Arg Cys Leu Thr Cys Thr Glu Lys Thr Val 
            500                 505                 510         


Leu His Asp Gly Lys Cys Met Ser Glu Cys Pro Gly Gly Tyr Tyr Ala 
        515                 520                 525             


Asp Ala Thr Gly Arg Cys Lys Val Cys His Asn Ser Cys Ala Ser Cys 
    530                 535                 540                 


Ser Gly Pro Thr Pro Ser His Cys Thr Ala Cys Ser Pro Pro Lys Ala 
545                 550                 555                 560 


Leu Arg Gln Gly His Cys Leu Pro Arg Cys Gly Glu Gly Phe Tyr Ser 
                565                 570                 575     


Asp His Gly Val Cys Lys Ala Cys His Ser Ser Cys Leu Ala Cys Met 
            580                 585                 590         


Gly Pro Ala Pro Ser His Cys Thr Gly Cys Lys Lys Pro Glu Glu Gly 
        595                 600                 605             


Leu Gln Val Glu Gln Leu Ser Asp Val Gly Ile Pro Ser Gly Glu Cys 
    610                 615                 620                 


Leu Ala Gln Cys Arg Ala His Phe Tyr Leu Glu Ser Thr Gly Ile Cys 
625                 630                 635                 640 


Glu Gly Gln Asn Leu Asp Phe Cys Gln Asn Leu Glu Val Ile Ser Ala 
                645                 650                 655     


Val Cys Leu Gly Ile Ser Ser Thr Glu Asn 
            660                 665     


<210>  5551
<211>  426
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5551

Xaa Thr Leu Pro Leu His Pro Asn Gln Gly Leu Pro Glu Ser Val Lys 
1               5                   10                  15      


Phe His Phe Thr Val Ser Asp Gly Glu His Thr Ser Pro Glu Met Val 
            20                  25                  30          


Leu Thr Ile His Leu Leu Pro Ser Asp Gln Gln Leu Pro Val Phe Gln 
        35                  40                  45              


Val Thr Ala Pro Arg Leu Ala Val Ser Pro Gly Gly Ser Thr Ser Val 
    50                  55                  60                  


Gly Leu Gln Val Val Val Arg Asp Ala Glu Thr Ala Pro Lys Glu Leu 
65                  70                  75                  80  


Phe Phe Glu Leu Arg Arg Pro Pro Gln His Gly Val Leu Leu Lys His 
                85                  90                  95      


Thr Ala Glu Phe Arg Arg Pro Met Ala Thr Gly Asp Thr Phe Thr Tyr 
            100                 105                 110         


Glu Asp Val Glu Lys Asn Ala Leu Gln Tyr Ile His Asp Gly Ser Ser 
        115                 120                 125             


Thr Arg Glu Asp Ser Met Glu Ile Ser Val Thr Asp Gly Leu Thr Val 
    130                 135                 140                 


Thr Met Leu Glu Val Arg Val Glu Val Ser Leu Ser Glu Asp Arg Gly 
145                 150                 155                 160 


Pro Arg Leu Ala Ala Gly Ser Ser Leu Ser Ile Thr Val Ala Ser Lys 
                165                 170                 175     


Ser Thr Ala Ile Ile Thr Arg Ser His Leu Ala Tyr Val Asp Asp Ser 
            180                 185                 190         


Ser Pro Asp Pro Glu Ile Trp Ile Gln Leu Asn Tyr Leu Pro Ser Tyr 
        195                 200                 205             


Gly Thr Leu Leu Arg Ile Ser Gly Ser Glu Val Glu Glu Leu Ser Glu 
    210                 215                 220                 


Val Ser Asn Phe Thr Met Glu Asp Ile Asn Asn Lys Lys Ile Arg Tyr 
225                 230                 235                 240 


Ser Ala Val Phe Glu Thr Asp Gly His Leu Val Thr Asp Ser Phe Tyr 
                245                 250                 255     


Phe Ser Val Ser Asp Met Asp His Asn His Leu Asp Asn Gln Ile Phe 
            260                 265                 270         


Thr Ile Met Ile Thr Pro Ala Glu Asn Pro Pro Pro Val Ile Ala Phe 
        275                 280                 285             


Ala Asp Leu Ile Thr Val Asp Glu Gly Gly Arg Ala Pro Leu Ser Phe 
    290                 295                 300                 


His His Phe Phe Ala Thr Asp Asp Asp Asp Asn Leu Gln Arg Asp Ala 
305                 310                 315                 320 


Ile Ile Lys Leu Ser Ala Leu Pro Lys Tyr Gly Cys Ile Glu Asn Thr 
                325                 330                 335     


Gly Thr Gly Asp Arg Phe Gly Pro Glu Thr Ala Ser Asp Leu Glu Ala 
            340                 345                 350         


Ser Phe Pro Ile Gln Asp Val Leu Glu Asn Tyr Ile Tyr Tyr Phe Gln 
        355                 360                 365             


Ser Val His Glu Ser Ile Glu Pro Thr His Asp Ile Phe Ser Phe Tyr 
    370                 375                 380                 


Val Ser Asp Gly Thr Ser Arg Ser Glu Ile His Ser Ile Asn Ile Thr 
385                 390                 395                 400 


Ile Glu Val Lys Thr Leu Glu Val Gly Lys Val Glu Pro Leu Thr Thr 
                405                 410                 415     


Ile Phe His Thr Ile Arg Glu Leu Ser Leu 
            420                 425     


<210>  5552
<211>  222
<212>  PRT
<213>  Homo Sapiens

<400>  5552

Met Leu Asp Glu Ser Leu Ala Val Arg Arg Ser Lys Lys Cys Lys Glu 
1               5                   10                  15      


Met Ile Met His Trp Glu Lys Lys Glu Asp Ile Asp Ile Val Asn Thr 
            20                  25                  30          


Val Asp Gln Leu Asp Lys Thr Ala Pro Arg Ile Thr Leu Leu His Ser 
        35                  40                  45              


Pro Ser Gln Val Gly Leu Leu Lys Asn Gly Cys Tyr Gly Ile Tyr Ile 
    50                  55                  60                  


Thr Ser Arg Val Leu Lys Ala Ser Asp Pro Asp Thr Glu Asp Asp Gln 
65                  70                  75                  80  


Ile Ile Phe Lys Ile Leu Gln Gly Pro Lys His Gly His Leu Glu Asn 
                85                  90                  95      


Thr Thr Thr Gly Glu Phe Ile His Glu Lys Phe Ser Gln Lys Asp Leu 
            100                 105                 110         


Asn Ser Lys Thr Ile Leu Tyr Ile Ile Asn Pro Ser Leu Glu Val Asn 
        115                 120                 125             


Ser Asp Thr Val Glu Phe Gln Ile Met Asp Pro Thr Gly Asn Ser Ala 
    130                 135                 140                 


Thr Pro Gln Ile Leu Glu Leu Lys Trp Ser His Ile Glu Trp Ser Gln 
145                 150                 155                 160 


Thr Glu Tyr Glu Val Cys Glu Asn Val Gly Leu Leu Pro Leu Glu Ile 
                165                 170                 175     


Ile Arg Arg Gly Tyr Ser Met Asp Ser Ala Phe Val Gly Ile Lys Val 
            180                 185                 190         


Asn Gln Val Ser Ala Ala Val Gly Lys Asp Phe Thr Val Ile Pro Ser 
        195                 200                 205             


Lys Leu Ile Gln Phe Asp Pro Gly Ser Ser Ile Leu Cys Leu 
    210                 215                 220         


<210>  5553
<211>  2179
<212>  PRT
<213>  Homo Sapiens

<400>  5553

Met Asn Ser Leu Ser Trp Gly Ala Ala Asn Ala Val Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ala Trp Ala Ser Pro Thr Phe Ile Ser Ile Asn Arg Gly Val 
            20                  25                  30          


Arg Val Met Lys Gly His Ser Ala Phe Leu Ser Gly Asp Asp Leu Lys 
        35                  40                  45              


Phe Ala Ile Pro Lys Glu Lys Asp Ala Cys Lys Val Glu Val Val Met 
    50                  55                  60                  


Asn Glu Pro Ile Thr Gln Arg Val Gly Lys Leu Thr Pro Gln Val Phe 
65                  70                  75                  80  


Asp Cys His Phe Leu Pro Asn Glu Val Lys Tyr Val His Asn Gly Cys 
                85                  90                  95      


Pro Ile Leu Asp Glu Asp Thr Val Lys Leu Arg Leu Tyr Arg Phe Thr 
            100                 105                 110         


Glu Arg Asp Thr Phe Ile Glu Thr Phe Ile Leu Trp Val Tyr Leu Leu 
        115                 120                 125             


Glu Pro Asp Cys Asn Ile Ile His Met Ser Asn Asn Val Leu Glu Val 
    130                 135                 140                 


Pro Glu Phe Asn Gly Leu Ser Gln Ala Ile Asp Lys Asn Leu Leu Arg 
145                 150                 155                 160 


Phe Asp Tyr Asp Arg Met Ala Ser Leu Glu Cys Thr Val Ser Leu Asp 
                165                 170                 175     


Thr Ala Arg Thr Arg Leu Pro Ala His Gly Gln Met Val Leu Gly Glu 
            180                 185                 190         


Pro Arg Pro Glu Glu Pro Arg Gly Asp Gln Pro His Ser Phe Phe Pro 
        195                 200                 205             


Glu Ser Gln Leu Arg Ala Lys Leu Lys Cys Pro Gly Gly Ser Cys Thr 
    210                 215                 220                 


Pro Gly Leu Lys Lys Ile Gly Ser Leu Lys Val Ser Cys Glu Glu Phe 
225                 230                 235                 240 


Leu Leu Met Gly Leu Arg Tyr Gln His Leu Asp Pro Pro Ser Pro Asn 
                245                 250                 255     


Ile Asp Tyr Ile Ser Ile Gln Leu Asp Leu Thr Asp Thr Arg Ser Lys 
            260                 265                 270         


Ile Val Tyr Lys Ser Glu Ser Ala Trp Leu Pro Val Tyr Ile Arg Ala 
        275                 280                 285             


Gly Ile Pro Asn Gln Ile Pro Lys Ala Ala Phe Met Ala Val Phe Ile 
    290                 295                 300                 


Leu Glu Val Asp Gln Phe Ile Leu Thr Ser Leu Thr Thr Ser Val Leu 
305                 310                 315                 320 


Asp Cys Glu Glu Asp Glu Thr Pro Lys Pro Leu Leu Val Phe Asn Ile 
                325                 330                 335     


Thr Lys Ala Pro Leu Gln Gly Tyr Val Thr His Leu Leu Asp His Thr 
            340                 345                 350         


Arg Pro Ile Ser Ser Phe Thr Trp Lys Asp Leu Ser Asp Met Gln Ile 
        355                 360                 365             


Ala Tyr Gln Pro Pro Asn Ser Ser His Ser Glu Arg Arg His Asp Glu 
    370                 375                 380                 


Val Glu Leu Glu Val Tyr Asp Phe Phe Phe Glu Arg Ser Ala Pro Met 
385                 390                 395                 400 


Thr Val His Ile Ser Ile Arg Thr Ala Asp Thr Asn Ala Pro Arg Val 
                405                 410                 415     


Ser Trp Asn Thr Gly Leu Ser Leu Leu Glu Gly Gln Ser Arg Ala Ile 
            420                 425                 430         


Thr Trp Glu Gln Phe Gln Val Val Asp Asn Asp Asp Ile Gly Ala Val 
        435                 440                 445             


Arg Leu Val Thr Val Gly Gly Leu Gln His Gly Trp Leu Thr Leu Arg 
    450                 455                 460                 


Gly Gly Lys Gly Phe Leu Phe Thr Val Ala Asp Leu Gln Ala Gly Val 
465                 470                 475                 480 


Val Arg Tyr His His Asp Asp Ser Asp Ser Thr Lys Asp Phe Val Val 
                485                 490                 495     


Phe Arg Ile Phe Asp Gly His His Ser Ile Arg His Lys Phe Pro Ile 
            500                 505                 510         


Asn Val Leu Pro Lys Asp Asp Ser Pro Pro Phe Leu Ile Thr Asn Val 
        515                 520                 525             


Val Ile Glu Leu Glu Glu Gly Gln Thr Ile Leu Ile Gln Gly Ser Met 
    530                 535                 540                 


Leu Arg Ala Ser Asp Val Asp Ala Ser Asp Asp Tyr Ile Phe Phe Asn 
545                 550                 555                 560 


Ile Thr Lys Pro Pro Gln Ala Gly Glu Ile Met Lys Lys Pro Gly Pro 
                565                 570                 575     


Gly Leu Ile Gly Tyr Pro Val His Gly Phe Leu Gln Arg Asp Leu Phe 
            580                 585                 590         


Asn Gly Ile Ile Tyr Tyr Arg His Phe Gly Gly Glu Ile Phe Glu Asp 
        595                 600                 605             


Ser Phe Gln Phe Val Leu Trp Asp Ser His Glu Pro Pro Asn Leu Ser 
    610                 615                 620                 


Val Pro Gln Val Ala Thr Ile His Ile Thr Pro Val Asp Asp Gln Leu 
625                 630                 635                 640 


Pro Lys Glu Ala Pro Gly Val Ser Arg His Leu Val Val Lys Glu Thr 
                645                 650                 655     


Glu Val Ala Tyr Ile Thr Lys Lys Gln Leu His Phe Ile Asp Ser Glu 
            660                 665                 670         


Ser Tyr Asp Arg Glu Leu Val Tyr Thr Ile Thr Thr Pro Pro Phe Phe 
        675                 680                 685             


Ser Phe Ser His Arg His Leu Asp Ala Gly Lys Leu Phe Met Val Asp 
    690                 695                 700                 


Ser Ile Pro Lys Val Val Lys Asn Pro Thr Ala Leu Glu Leu Arg Ser 
705                 710                 715                 720 


Phe Thr Gln His Ala Val Asn Tyr Met Lys Val Ala Tyr Met Pro Pro 
                725                 730                 735     


Met Gln Asp Ile Gly Pro His Cys Arg Asp Val Gln Phe Thr Phe Ser 
            740                 745                 750         


Val Ser Asn Gln His Gly Gly Thr Leu His Gly Ile Cys Phe Asn Ile 
        755                 760                 765             


Thr Ile Leu Pro Val Asp Asn Gln Val Pro Glu Ala Phe Thr Asn Pro 
    770                 775                 780                 


Leu Lys Val Thr Glu Gly Gly Gln Ser Ile Ile Ser Thr Glu His Ile 
785                 790                 795                 800 


Leu Ile Ser Asp Ala Asp Thr Lys Leu Asp Asn Ile Asp Leu Ser Leu 
                805                 810                 815     


Arg Glu Leu Pro Leu His Gly Arg Val Glu Leu Asn Gly Phe Pro Leu 
            820                 825                 830         


Asn Ser Gly Gly Thr Phe Ser Trp Gly Asp Leu His Thr Leu Lys Val 
        835                 840                 845             


Arg Tyr Gln His Asp Gly Thr Glu Val Leu Gln Asp Asp Leu Leu Leu 
    850                 855                 860                 


Glu Val Thr Asp Gly Thr Asn Ser Ala Glu Phe Val Leu His Val Glu 
865                 870                 875                 880 


Val Phe Pro Val Asn Asp Glu Pro Pro Val Leu Lys Ala Asp Leu Met 
                885                 890                 895     


Pro Val Met Asn Cys Ser Glu Gly Gly Glu Val Val Ile Thr Ser Glu 
            900                 905                 910         


Tyr Ile Phe Ala Thr Asp Val Asp Ser Asp Asn Leu Lys Leu Met Phe 
        915                 920                 925             


Val Ile Ala Arg Glu Pro Gln His Gly Val Val Arg Arg Ala Gly Val 
    930                 935                 940                 


Thr Val Asp Gln Phe Ser Gln Arg Asp Val Ile Ser Glu Ala Val Thr 
945                 950                 955                 960 


Tyr Lys His Thr Gly Gly Glu Ile Gly Leu Met Pro Cys Phe Asp Thr 
                965                 970                 975     


Ile Thr Leu Val Val Ser Asp Gly Glu Ala Gly Pro Phe Val Asn Gly 
            980                 985                 990         


Cys Cys Tyr Asn Gly Pro Asn Pro  Ser Val Pro Leu His  Ala Ser Phe 
        995                 1000                 1005             


Pro Val  Tyr Asp Leu Asn Ile  Thr Val Tyr Pro Val  Asp Asn Gln 
    1010                 1015                 1020             


Pro Pro  Ser Ile Ala Ile Gly  Pro Val Phe Val Val  Asp Glu Gly 
    1025                 1030                 1035             


Cys Ser  Thr Ala Leu Thr Val  Asn His Leu Ser Ala  Thr Asp Pro 
    1040                 1045                 1050             


Asp Thr  Ala Ala Asp Asp Leu  Glu Phe Val Leu Val  Ser Pro Pro 
    1055                 1060                 1065             


Gln Phe  Gly Tyr Leu Glu Asn  Ile Leu Pro Ser Val  Gly Phe Glu 
    1070                 1075                 1080             


Lys Ser  Asn Ile Gly Ile Ser  Ile Asp Ser Phe Gln  Trp Lys Asp 
    1085                 1090                 1095             


Met Asn  Ala Phe His Ile Asn  Tyr Val Gln Ser Arg  His Leu Arg 
    1100                 1105                 1110             


Ile Glu  Pro Thr Ala Asp Gln  Phe Thr Val Tyr Val  Thr Asp Gly 
    1115                 1120                 1125             


Lys His  His Ser Leu Glu Ile  Pro Phe Ser Ile Ile  Ile Asn Pro 
    1130                 1135                 1140             


Thr Asn  Asp Glu Ala Pro Asp  Phe Val Val Gln Asn  Ile Thr Val 
    1145                 1150                 1155             


Cys Glu  Gly Gln Met Lys Glu  Leu Asp Ser Ser Ile  Ile Ser Ala 
    1160                 1165                 1170             


Val Asp  Leu Asp Ile Pro Gln  Asp Ala Leu Leu Phe  Ser Ile Thr 
    1175                 1180                 1185             


Gln Lys  Pro Arg His Gly Leu  Leu Ile Asp Arg Gly  Phe Ser Lys 
    1190                 1195                 1200             


Asp Phe  Ser Glu Asn Lys Gln  Pro Ala Asn Pro His  Gln Lys His 
    1205                 1210                 1215             


Ala Pro  Val His Ser Phe Ser  Met Glu Leu Leu Lys  Thr Gly Met 
    1220                 1225                 1230             


Arg Leu  Thr Tyr Met His Asp  Asp Ser Glu Ser Leu  Ala Asp Asp 
    1235                 1240                 1245             


Phe Thr  Ile Gln Leu Ser Asp  Gly Lys His Lys Ile  Leu Lys Thr 
    1250                 1255                 1260             


Ile Ser  Val Glu Val Ile Pro  Val Asn Asp Glu Lys  Pro Met Leu 
    1265                 1270                 1275             


Ser Lys  Lys Ala Glu Ile Ala  Met Asn Met Gly Glu  Thr Arg Ile 
    1280                 1285                 1290             


Ile Ser  Ser Ala Ile Leu Ser  Ala Ile Asp Glu Asp  Ser Pro Arg 
    1295                 1300                 1305             


Glu Lys  Ile Tyr Tyr Val Phe  Glu Arg Leu Pro Gln  Asn Gly Gln 
    1310                 1315                 1320             


Leu Gln  Leu Lys Ile Gly Arg  Asp Trp Val Pro Leu  Ser Pro Gly 
    1325                 1330                 1335             


Met Lys  Cys Thr Gln Glu Glu  Val Asp Leu Asn Leu  Leu Arg Tyr 
    1340                 1345                 1350             


Thr His  Thr Gly Ala Met Asp  Ser Gln Asn Gln Asp  Ser Phe Thr 
    1355                 1360                 1365             


Phe Tyr  Leu Trp Asp Gly Asn  Asn Arg Ser Pro Ala  Leu Asp Cys 
    1370                 1375                 1380             


Gln Ile  Thr Ile Lys Asp Met  Glu Lys Gly Asp Ile  Val Ile Leu 
    1385                 1390                 1395             


Thr Lys  Pro Leu Val Val Ser  Lys Gly Asp Arg Gly  Phe Leu Thr 
    1400                 1405                 1410             


Thr Thr  Thr Leu Leu Ala Val  Asp Gly Thr Asp Lys  Pro Glu Glu 
    1415                 1420                 1425             


Leu Leu  Tyr Val Ile Thr Ser  Pro Pro Arg Tyr Gly  Gln Ile Glu 
    1430                 1435                 1440             


Tyr Val  His Tyr Pro Gly Val  Pro Ile Thr Asn Phe  Ser Gln Met 
    1445                 1450                 1455             


Asp Val  Val Gly Gln Thr Val  Cys Tyr Val His Lys  Ser Lys Val 
    1460                 1465                 1470             


Thr Val  Ser Ser Asp Arg Phe  Arg Phe Ile Ile Ser  Asn Gly Leu 
    1475                 1480                 1485             


Arg Thr  Glu His Gly Val Phe  Glu Ile Thr Leu Glu  Thr Val Asp 
    1490                 1495                 1500             


Arg Ala  Leu Pro Val Val Thr  Arg Asn Lys Gly Leu  Arg Leu Ala 
    1505                 1510                 1515             


Gln Gly  Ala Val Gly Leu Leu  Ser Pro Asp Leu Leu  Gln Leu Thr 
    1520                 1525                 1530             


Asp Pro  Asp Thr Pro Ala Glu  Asn Leu Thr Phe Leu  Leu Val Gln 
    1535                 1540                 1545             


Leu Pro  Gln His Gly Gln Leu  Tyr Leu Trp Gly Thr  Gly Leu Leu 
    1550                 1555                 1560             


Gln His  Asn Phe Thr Gln Gln  Asp Val Asp Ser Lys  Asn Val Ala 
    1565                 1570                 1575             


Tyr Arg  His Ser Gly Gly Asp  Ser Gln Thr Asp Cys  Phe Thr Phe 
    1580                 1585                 1590             


Met Ala  Thr Asp Gly Thr Asn  Gln Gly Phe Ile Val  Asn Gly Arg 
    1595                 1600                 1605             


Val Trp  Glu Glu Pro Val Leu  Phe Thr Ile Gln Val  Asp Gln Leu 
    1610                 1615                 1620             


Asp Lys  Thr Ala Pro Arg Ile  Thr Leu Leu His Ser  Pro Ser Gln 
    1625                 1630                 1635             


Val Gly  Leu Leu Lys Asn Gly  Cys Tyr Gly Ile Tyr  Ile Thr Ser 
    1640                 1645                 1650             


Arg Val  Leu Lys Ala Ser Asp  Pro Asp Thr Glu Asp  Asp Gln Ile 
    1655                 1660                 1665             


Ile Phe  Lys Ile Leu Gln Gly  Pro Lys His Gly His  Leu Glu Asn 
    1670                 1675                 1680             


Thr Thr  Thr Gly Glu Phe Ile  His Glu Lys Phe Ser  Gln Lys Asp 
    1685                 1690                 1695             


Leu Asn  Ser Lys Thr Ile Leu  Tyr Ile Ile Asn Pro  Ser Leu Glu 
    1700                 1705                 1710             


Val Asn  Ser Asp Thr Val Glu  Phe Gln Ile Met Asp  Pro Thr Gly 
    1715                 1720                 1725             


Asn Ser  Ala Thr Pro Gln Ile  Leu Glu Leu Lys Trp  Ser His Ile 
    1730                 1735                 1740             


Glu Trp  Ser Gln Thr Glu Tyr  Glu Val Cys Glu Asn  Val Gly Leu 
    1745                 1750                 1755             


Leu Pro  Leu Glu Ile Ile Arg  Arg Gly Tyr Ser Met  Asp Ser Ala 
    1760                 1765                 1770             


Phe Val  Gly Ile Lys Val Asn  Gln Val Ser Ala Ala  Val Gly Lys 
    1775                 1780                 1785             


Asp Phe  Thr Val Ile Pro Ser  Lys Leu Ile Gln Phe  Asp Pro Gly 
    1790                 1795                 1800             


Met Ser  Thr Lys Met Trp Asn  Ile Ala Ile Thr Tyr  Asp Gly Leu 
    1805                 1810                 1815             


Glu Glu  Asp Asp Glu Val Phe  Glu Val Ile Leu Asn  Ser Pro Val 
    1820                 1825                 1830             


Asn Ala  Val Leu Gly Thr Lys  Thr Lys Ala Ala Val  Lys Ile Leu 
    1835                 1840                 1845             


Asp Ser  Lys Gly Gly Gln Cys  His Pro Ser Tyr Ser  Ser Asn Gln 
    1850                 1855                 1860             


Ser Lys  His Ser Thr Trp Glu  Lys Gly Ile Trp His  Leu Leu Pro 
    1865                 1870                 1875             


Pro Gly  Ser Ser Ser Ser Thr  Thr Ser Gly Ser Phe  His Leu Glu 
    1880                 1885                 1890             


Arg Arg  Pro Leu Pro Ser Ser  Met Gln Leu Ala Val  Ile Arg Gly 
    1895                 1900                 1905             


Asp Thr  Leu Arg Gly Phe Asp  Ser Thr Asp Leu Ser  Gln Arg Lys 
    1910                 1915                 1920             


Leu Arg  Thr Arg Gly Asn Gly  Lys Thr Val Arg Pro  Ser Ser Val 
    1925                 1930                 1935             


Tyr Arg  Asn Gly Thr Asp Ile  Ile Tyr Asn Tyr His  Gly Ile Val 
    1940                 1945                 1950             


Ser Leu  Lys Leu Glu Asp Asp  Ser Phe Pro Thr His  Lys Arg Lys 
    1955                 1960                 1965             


Ala Lys  Val Ser Ile Ile Ser  Gln Pro Gln Lys Thr  Ile Lys Val 
    1970                 1975                 1980             


Ala Glu  Leu Pro Gln Ala Asp  Lys Val Glu Ser Thr  Thr Asp Ser 
    1985                 1990                 1995             


His Phe  Pro Arg Gln Asp Gln  Leu Pro Ser Phe Pro  Lys Asn Cys 
    2000                 2005                 2010             


Thr Leu  Glu Leu Lys Gly Leu  Phe His Phe Glu Glu  Gly Ile Gln 
    2015                 2020                 2025             


Lys Leu  Tyr Gln Cys Asn Gly  Ile Ala Trp Lys Ala  Trp Ser Pro 
    2030                 2035                 2040             


Gln Thr  Lys Asp Val Glu Asp  Lys Ser Cys Pro Ala  Gly Trp His 
    2045                 2050                 2055             


Gln His  Ser Gly Tyr Cys His  Ile Leu Ile Thr Glu  Gln Lys Gly 
    2060                 2065                 2070             


Thr Trp  Asn Ala Ala Ala Gln  Ala Cys Arg Glu Gln  Tyr Leu Gly 
    2075                 2080                 2085             


Asn Leu  Val Thr Val Phe Ser  Arg Gln His Met Arg  Trp Leu Trp 
    2090                 2095                 2100             


Asp Ile  Gly Gly Arg Lys Ser  Phe Trp Ile Gly Leu  Asn Asp Gln 
    2105                 2110                 2115             


Val His  Ala Gly His Trp Glu  Trp Ile Gly Gly Glu  Pro Val Ala 
    2120                 2125                 2130             


Phe Thr  Asn Gly Arg Arg Gly  Pro Ser Gln Arg Ser  Lys Leu Gly 
    2135                 2140                 2145             


Lys Ser  Cys Val Leu Val Gln  Arg Gln Gly Lys Trp  Gln Thr Lys 
    2150                 2155                 2160             


Asp Cys  Arg Arg Ala Lys Pro  His Asn Tyr Val Cys  Ser Arg Lys 
    2165                 2170                 2175             


Leu 
    


<210>  5554
<211>  2179
<212>  PRT
<213>  Homo Sapiens

<400>  5554

Met Asn Ser Leu Ser Trp Gly Ala Ala Asn Ala Val Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ala Trp Ala Ser Pro Thr Phe Ile Ser Ile Asn Arg Gly Val 
            20                  25                  30          


Arg Val Met Lys Gly His Ser Ala Phe Leu Ser Gly Asp Asp Leu Lys 
        35                  40                  45              


Phe Ala Ile Pro Lys Glu Lys Asp Ala Cys Lys Val Glu Val Val Met 
    50                  55                  60                  


Asn Glu Pro Ile Thr Gln Arg Val Gly Lys Leu Thr Pro Gln Val Phe 
65                  70                  75                  80  


Asp Cys His Phe Leu Pro Asn Glu Val Lys Tyr Val His Asn Gly Cys 
                85                  90                  95      


Pro Ile Leu Asp Glu Asp Thr Val Lys Leu Arg Leu Tyr Arg Phe Thr 
            100                 105                 110         


Glu Arg Asp Thr Phe Ile Glu Thr Phe Ile Leu Trp Val Tyr Leu Leu 
        115                 120                 125             


Glu Pro Asp Cys Asn Ile Ile His Met Ser Asn Asn Val Leu Glu Val 
    130                 135                 140                 


Pro Glu Phe Asn Gly Leu Ser Gln Ala Ile Asp Lys Asn Leu Leu Arg 
145                 150                 155                 160 


Phe Asp Tyr Asp Arg Met Ala Ser Leu Glu Cys Thr Val Ser Leu Asp 
                165                 170                 175     


Thr Ala Arg Thr Arg Leu Pro Ala His Gly Gln Met Val Leu Gly Glu 
            180                 185                 190         


Pro Arg Pro Glu Glu Pro Arg Gly Asp Gln Pro His Ser Phe Phe Pro 
        195                 200                 205             


Glu Ser Gln Leu Arg Ala Lys Leu Lys Cys Pro Gly Gly Ser Cys Thr 
    210                 215                 220                 


Pro Gly Leu Lys Lys Ile Gly Ser Leu Lys Val Ser Cys Glu Glu Phe 
225                 230                 235                 240 


Leu Leu Met Gly Leu Arg Tyr Gln His Leu Asp Pro Pro Ser Pro Asn 
                245                 250                 255     


Ile Asp Tyr Ile Ser Ile Gln Leu Asp Leu Thr Asp Thr Arg Ser Lys 
            260                 265                 270         


Ile Val Tyr Lys Ser Glu Ser Ala Trp Leu Pro Val Tyr Ile Arg Ala 
        275                 280                 285             


Gly Ile Pro Asn Gln Ile Pro Lys Ala Ala Phe Met Ala Val Phe Ile 
    290                 295                 300                 


Leu Glu Val Asp Gln Phe Ile Leu Thr Ser Leu Thr Thr Ser Val Leu 
305                 310                 315                 320 


Asp Cys Glu Glu Asp Glu Thr Pro Lys Pro Leu Leu Val Phe Asn Ile 
                325                 330                 335     


Thr Lys Ala Pro Leu Gln Gly Tyr Val Thr His Leu Leu Asp His Thr 
            340                 345                 350         


Arg Pro Ile Ser Ser Phe Thr Trp Lys Asp Leu Ser Asp Met Gln Ile 
        355                 360                 365             


Ala Tyr Gln Pro Pro Asn Ser Ser His Ser Glu Arg Arg His Asp Glu 
    370                 375                 380                 


Val Glu Leu Glu Val Tyr Asp Phe Phe Phe Glu Arg Ser Ala Pro Met 
385                 390                 395                 400 


Thr Val His Ile Ser Ile Arg Thr Ala Asp Thr Asn Ala Pro Arg Val 
                405                 410                 415     


Ser Trp Asn Thr Gly Leu Ser Leu Leu Glu Gly Gln Ser Arg Ala Ile 
            420                 425                 430         


Thr Trp Glu Gln Phe Gln Val Val Asp Asn Asp Asp Ile Gly Ala Val 
        435                 440                 445             


Arg Leu Val Thr Val Gly Gly Leu Gln His Gly Trp Leu Thr Leu Arg 
    450                 455                 460                 


Gly Gly Lys Gly Phe Leu Phe Thr Val Ala Asp Leu Gln Ala Gly Val 
465                 470                 475                 480 


Val Arg Tyr His His Asp Asp Ser Asp Ser Thr Lys Asp Phe Val Val 
                485                 490                 495     


Phe Arg Ile Phe Asp Gly His His Ser Ile Arg His Lys Phe Pro Ile 
            500                 505                 510         


Asn Val Leu Pro Lys Asp Asp Ser Pro Pro Phe Leu Ile Thr Asn Val 
        515                 520                 525             


Val Ile Glu Leu Glu Glu Gly Gln Thr Ile Leu Ile Gln Gly Ser Met 
    530                 535                 540                 


Leu Arg Ala Ser Asp Val Asp Ala Ser Asp Asp Tyr Ile Phe Phe Asn 
545                 550                 555                 560 


Ile Thr Lys Pro Pro Gln Ala Gly Glu Ile Met Lys Lys Pro Gly Pro 
                565                 570                 575     


Gly Leu Ile Gly Tyr Pro Val His Gly Phe Leu Gln Arg Asp Leu Phe 
            580                 585                 590         


Asn Gly Ile Ile Tyr Tyr Arg His Phe Gly Gly Glu Ile Phe Glu Asp 
        595                 600                 605             


Ser Phe Gln Phe Val Leu Trp Asp Ser His Glu Pro Pro Asn Leu Ser 
    610                 615                 620                 


Val Pro Gln Val Ala Thr Ile His Ile Thr Pro Val Asp Asp Gln Leu 
625                 630                 635                 640 


Pro Lys Glu Ala Pro Gly Val Ser Arg His Leu Val Val Lys Glu Thr 
                645                 650                 655     


Glu Val Ala Tyr Ile Thr Lys Lys Gln Leu His Phe Ile Asp Ser Glu 
            660                 665                 670         


Ser Tyr Asp Arg Glu Leu Val Tyr Thr Ile Thr Thr Pro Pro Phe Phe 
        675                 680                 685             


Ser Phe Ser His Arg His Leu Asp Ala Gly Lys Leu Phe Met Val Asp 
    690                 695                 700                 


Ser Ile Pro Lys Val Val Lys Asn Pro Thr Ala Leu Glu Leu Arg Ser 
705                 710                 715                 720 


Phe Thr Gln His Ala Val Asn Tyr Met Lys Val Ala Tyr Met Pro Pro 
                725                 730                 735     


Met Gln Asp Ile Gly Pro His Cys Arg Asp Val Gln Phe Thr Phe Ser 
            740                 745                 750         


Val Ser Asn Gln His Gly Gly Thr Leu His Gly Ile Cys Phe Asn Ile 
        755                 760                 765             


Thr Ile Leu Pro Val Asp Asn Gln Val Pro Glu Ala Phe Thr Asn Pro 
    770                 775                 780                 


Leu Lys Val Thr Glu Gly Gly Gln Ser Ile Ile Ser Thr Glu His Ile 
785                 790                 795                 800 


Leu Ile Ser Asp Ala Asp Thr Lys Leu Asp Asn Ile Asp Leu Ser Leu 
                805                 810                 815     


Arg Glu Leu Pro Leu His Gly Arg Val Glu Leu Asn Gly Phe Pro Leu 
            820                 825                 830         


Asn Ser Gly Gly Thr Phe Ser Trp Gly Asp Leu His Thr Leu Lys Val 
        835                 840                 845             


Arg Tyr Gln His Asp Gly Thr Glu Val Leu Gln Asp Asp Leu Leu Leu 
    850                 855                 860                 


Glu Val Thr Asp Gly Thr Asn Ser Ala Glu Phe Val Leu His Val Glu 
865                 870                 875                 880 


Val Phe Pro Val Asn Asp Glu Pro Pro Val Leu Lys Ala Asp Leu Met 
                885                 890                 895     


Pro Val Met Asn Cys Ser Glu Gly Gly Glu Val Val Ile Thr Ser Glu 
            900                 905                 910         


Tyr Ile Phe Ala Thr Asp Val Asp Ser Asp Asn Leu Lys Leu Met Phe 
        915                 920                 925             


Val Ile Ala Arg Glu Pro Gln His Gly Val Val Arg Arg Ala Gly Val 
    930                 935                 940                 


Thr Val Asp Gln Phe Ser Gln Arg Asp Val Ile Ser Glu Ala Val Thr 
945                 950                 955                 960 


Tyr Lys His Thr Gly Gly Glu Ile Gly Leu Met Pro Cys Phe Asp Thr 
                965                 970                 975     


Ile Thr Leu Val Val Ser Asp Gly Glu Ala Gly Pro Phe Val Asn Gly 
            980                 985                 990         


Cys Cys Tyr Asn Gly Pro Asn Pro  Ser Val Pro Leu His  Ala Ser Phe 
        995                 1000                 1005             


Pro Val  Tyr Asp Leu Asn Ile  Thr Val Tyr Pro Val  Asp Asn Gln 
    1010                 1015                 1020             


Pro Pro  Ser Ile Ala Ile Gly  Pro Val Phe Val Val  Asp Glu Gly 
    1025                 1030                 1035             


Cys Ser  Thr Ala Leu Thr Val  Asn His Leu Ser Ala  Thr Asp Pro 
    1040                 1045                 1050             


Asp Thr  Ala Ala Asp Asp Leu  Glu Phe Val Leu Val  Ser Pro Pro 
    1055                 1060                 1065             


Gln Phe  Gly Tyr Leu Glu Asn  Ile Leu Pro Ser Val  Gly Phe Glu 
    1070                 1075                 1080             


Lys Ser  Asn Ile Gly Ile Ser  Ile Asp Ser Phe Gln  Trp Lys Asp 
    1085                 1090                 1095             


Met Asn  Ala Phe His Ile Asn  Tyr Val Gln Ser Arg  His Leu Arg 
    1100                 1105                 1110             


Ile Glu  Pro Thr Ala Asp Gln  Phe Thr Val Tyr Val  Thr Asp Gly 
    1115                 1120                 1125             


Lys His  His Ser Leu Glu Ile  Pro Phe Ser Ile Ile  Ile Asn Pro 
    1130                 1135                 1140             


Thr Asn  Asp Glu Ala Pro Asp  Phe Val Val Gln Asn  Ile Thr Val 
    1145                 1150                 1155             


Cys Glu  Gly Gln Met Lys Glu  Leu Asp Ser Ser Ile  Ile Ser Ala 
    1160                 1165                 1170             


Val Asp  Leu Asp Ile Pro Gln  Asp Ala Leu Leu Phe  Ser Ile Thr 
    1175                 1180                 1185             


Gln Lys  Pro Arg His Gly Leu  Leu Ile Asp Arg Gly  Phe Ser Lys 
    1190                 1195                 1200             


Asp Phe  Ser Glu Asn Lys Gln  Pro Ala Asn Pro His  Gln Lys His 
    1205                 1210                 1215             


Ala Pro  Val His Ser Phe Ser  Met Glu Leu Leu Lys  Thr Gly Met 
    1220                 1225                 1230             


Arg Leu  Thr Tyr Met His Asp  Asp Ser Glu Ser Leu  Ala Asp Asp 
    1235                 1240                 1245             


Phe Thr  Ile Gln Leu Ser Asp  Gly Lys His Lys Ile  Leu Lys Thr 
    1250                 1255                 1260             


Ile Ser  Val Glu Val Ile Pro  Val Asn Asp Glu Lys  Pro Met Leu 
    1265                 1270                 1275             


Ser Lys  Lys Ala Glu Ile Ala  Met Asn Met Gly Glu  Thr Arg Ile 
    1280                 1285                 1290             


Ile Ser  Ser Ala Ile Leu Ser  Ala Ile Asp Glu Asp  Ser Pro Arg 
    1295                 1300                 1305             


Glu Lys  Ile Tyr Tyr Val Phe  Glu Arg Leu Pro Gln  Asn Gly Gln 
    1310                 1315                 1320             


Leu Gln  Leu Lys Ile Gly Arg  Asp Trp Val Pro Leu  Ser Pro Gly 
    1325                 1330                 1335             


Met Lys  Cys Thr Gln Glu Glu  Val Asp Leu Asn Leu  Leu Arg Tyr 
    1340                 1345                 1350             


Thr His  Thr Gly Ala Met Asp  Ser Gln Asn Gln Asp  Ser Phe Thr 
    1355                 1360                 1365             


Phe Tyr  Leu Trp Asp Gly Asn  Asn Arg Ser Pro Ala  Leu Asp Cys 
    1370                 1375                 1380             


Gln Ile  Thr Ile Lys Asp Met  Glu Lys Gly Asp Ile  Val Ile Leu 
    1385                 1390                 1395             


Thr Lys  Pro Leu Val Val Ser  Lys Gly Asp Arg Gly  Phe Leu Thr 
    1400                 1405                 1410             


Thr Thr  Thr Leu Leu Ala Val  Asp Gly Thr Asp Lys  Pro Glu Glu 
    1415                 1420                 1425             


Leu Leu  Tyr Val Ile Thr Ser  Pro Pro Arg Tyr Gly  Gln Ile Glu 
    1430                 1435                 1440             


Tyr Val  His Tyr Pro Gly Val  Pro Ile Thr Asn Phe  Ser Gln Met 
    1445                 1450                 1455             


Asp Val  Val Gly Gln Thr Val  Cys Tyr Val His Lys  Ser Lys Val 
    1460                 1465                 1470             


Thr Val  Ser Ser Asp Arg Phe  Arg Phe Ile Ile Ser  Asn Gly Leu 
    1475                 1480                 1485             


Arg Thr  Glu His Gly Val Phe  Glu Ile Thr Leu Glu  Thr Val Asp 
    1490                 1495                 1500             


Arg Ala  Leu Pro Val Val Thr  Arg Asn Lys Gly Leu  Arg Leu Ala 
    1505                 1510                 1515             


Gln Gly  Ala Val Gly Leu Leu  Ser Pro Asp Leu Leu  Gln Leu Thr 
    1520                 1525                 1530             


Asp Pro  Asp Thr Pro Ala Glu  Asn Leu Thr Phe Leu  Leu Val Gln 
    1535                 1540                 1545             


Leu Pro  Gln His Gly Gln Leu  Tyr Leu Trp Gly Thr  Gly Leu Leu 
    1550                 1555                 1560             


Gln His  Asn Phe Thr Gln Gln  Asp Val Asp Ser Lys  Asn Val Ala 
    1565                 1570                 1575             


Tyr Arg  His Ser Gly Gly Asp  Ser Gln Thr Asp Cys  Phe Thr Phe 
    1580                 1585                 1590             


Met Ala  Thr Asp Gly Thr Asn  Gln Gly Phe Ile Val  Asn Gly Arg 
    1595                 1600                 1605             


Val Trp  Glu Glu Pro Val Leu  Phe Thr Ile Gln Val  Asp Gln Leu 
    1610                 1615                 1620             


Asp Lys  Thr Ala Pro Arg Ile  Thr Leu Leu His Ser  Pro Ser Gln 
    1625                 1630                 1635             


Val Gly  Leu Leu Lys Asn Gly  Cys Tyr Gly Ile Tyr  Ile Thr Ser 
    1640                 1645                 1650             


Arg Val  Leu Lys Ala Ser Asp  Pro Asp Thr Glu Asp  Asp Gln Ile 
    1655                 1660                 1665             


Ile Phe  Lys Ile Leu Gln Gly  Pro Lys His Gly His  Leu Glu Asn 
    1670                 1675                 1680             


Thr Thr  Thr Gly Glu Phe Ile  His Glu Lys Phe Ser  Gln Lys Asp 
    1685                 1690                 1695             


Leu Asn  Ser Lys Thr Ile Leu  Tyr Ile Ile Asn Pro  Ser Leu Glu 
    1700                 1705                 1710             


Val Asn  Ser Asp Thr Val Glu  Phe Gln Ile Met Asp  Pro Thr Gly 
    1715                 1720                 1725             


Asn Ser  Ala Thr Pro Gln Ile  Leu Glu Leu Lys Trp  Ser His Ile 
    1730                 1735                 1740             


Glu Trp  Ser Gln Thr Glu Tyr  Glu Val Cys Glu Asn  Val Gly Leu 
    1745                 1750                 1755             


Leu Pro  Leu Glu Ile Ile Arg  Arg Gly Tyr Ser Met  Asp Ser Ala 
    1760                 1765                 1770             


Phe Val  Gly Ile Lys Val Asn  Gln Val Ser Ala Ala  Val Gly Lys 
    1775                 1780                 1785             


Asp Phe  Thr Val Ile Pro Ser  Lys Leu Ile Gln Phe  Asp Pro Gly 
    1790                 1795                 1800             


Met Ser  Thr Lys Met Trp Asn  Ile Ala Ile Thr Tyr  Asp Gly Leu 
    1805                 1810                 1815             


Glu Glu  Asp Asp Glu Val Phe  Glu Val Ile Leu Asn  Ser Pro Val 
    1820                 1825                 1830             


Asn Ala  Val Leu Gly Thr Lys  Thr Lys Ala Ala Val  Lys Ile Leu 
    1835                 1840                 1845             


Asp Ser  Lys Gly Gly Gln Cys  His Pro Ser Tyr Ser  Ser Asn Gln 
    1850                 1855                 1860             


Ser Lys  His Ser Thr Trp Glu  Lys Gly Ile Trp His  Leu Leu Pro 
    1865                 1870                 1875             


Pro Gly  Ser Ser Ser Ser Thr  Thr Ser Gly Ser Phe  His Leu Glu 
    1880                 1885                 1890             


Arg Arg  Pro Leu Pro Ser Ser  Met Gln Leu Ala Val  Ile Arg Gly 
    1895                 1900                 1905             


Asp Thr  Leu Arg Gly Phe Asp  Ser Thr Asp Leu Ser  Gln Arg Lys 
    1910                 1915                 1920             


Leu Arg  Thr Arg Gly Asn Gly  Lys Thr Val Arg Pro  Ser Ser Val 
    1925                 1930                 1935             


Tyr Arg  Asn Gly Thr Asp Ile  Ile Tyr Asn Tyr His  Gly Ile Val 
    1940                 1945                 1950             


Ser Leu  Lys Leu Glu Asp Asp  Ser Phe Pro Thr His  Lys Arg Lys 
    1955                 1960                 1965             


Ala Lys  Val Ser Ile Ile Ser  Gln Pro Gln Lys Thr  Ile Lys Val 
    1970                 1975                 1980             


Ala Glu  Leu Pro Gln Ala Asp  Lys Val Glu Ser Thr  Thr Asp Ser 
    1985                 1990                 1995             


His Phe  Pro Arg Gln Asp Gln  Leu Pro Ser Phe Pro  Lys Asn Cys 
    2000                 2005                 2010             


Thr Leu  Glu Leu Lys Gly Leu  Phe His Phe Glu Glu  Gly Ile Gln 
    2015                 2020                 2025             


Lys Leu  Tyr Gln Cys Asn Gly  Ile Ala Trp Lys Ala  Trp Ser Pro 
    2030                 2035                 2040             


Gln Thr  Lys Asp Val Glu Asp  Lys Ser Cys Pro Ala  Gly Trp His 
    2045                 2050                 2055             


Gln His  Ser Gly Tyr Cys His  Ile Leu Ile Thr Glu  Gln Lys Gly 
    2060                 2065                 2070             


Thr Trp  Asn Ala Ala Ala Gln  Ala Cys Arg Glu Gln  Tyr Leu Gly 
    2075                 2080                 2085             


Asn Leu  Val Thr Val Phe Ser  Arg Gln His Met Arg  Trp Leu Trp 
    2090                 2095                 2100             


Asp Ile  Gly Gly Arg Lys Ser  Phe Trp Ile Gly Leu  Asn Asp Gln 
    2105                 2110                 2115             


Val His  Ala Gly His Trp Glu  Trp Ile Gly Gly Glu  Pro Val Ala 
    2120                 2125                 2130             


Phe Thr  Asn Gly Arg Arg Gly  Pro Ser Gln Arg Ser  Lys Leu Gly 
    2135                 2140                 2145             


Lys Ser  Cys Val Leu Val Gln  Arg Gln Gly Lys Trp  Gln Thr Lys 
    2150                 2155                 2160             


Asp Cys  Arg Arg Ala Lys Pro  His Asn Tyr Val Cys  Ser Arg Lys 
    2165                 2170                 2175             


Leu 
    


<210>  5555
<211>  1335
<212>  PRT
<213>  Homo Sapiens

<400>  5555

Met Asn Ser Leu Ser Trp Gly Ala Ala Asn Ala Val Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ala Trp Ala Ser Pro Thr Phe Ile Ser Ile Asn Arg Gly Val 
            20                  25                  30          


Arg Val Met Lys Gly His Ser Ala Phe Leu Ser Gly Asp Asp Leu Lys 
        35                  40                  45              


Phe Ala Ile Pro Lys Glu Lys Asp Ala Cys Lys Val Glu Val Val Met 
    50                  55                  60                  


Asn Glu Pro Ile Thr Gln Arg Val Gly Lys Leu Thr Pro Gln Val Phe 
65                  70                  75                  80  


Asp Cys His Phe Leu Pro Asn Glu Val Lys Tyr Val His Asn Gly Cys 
                85                  90                  95      


Pro Ile Leu Asp Glu Asp Thr Val Lys Leu Arg Leu Tyr Arg Phe Thr 
            100                 105                 110         


Glu Arg Asp Thr Phe Ile Glu Thr Phe Ile Leu Trp Val Tyr Leu Leu 
        115                 120                 125             


Glu Pro Asp Cys Asn Ile Ile His Met Ser Asn Asn Val Leu Glu Val 
    130                 135                 140                 


Pro Glu Phe Asn Gly Leu Ser Gln Ala Ile Asp Lys Asn Leu Leu Arg 
145                 150                 155                 160 


Phe Asp Tyr Asp Arg Met Ala Ser Leu Glu Cys Thr Val Ser Leu Asp 
                165                 170                 175     


Thr Ala Arg Thr Arg Leu Pro Ala His Gly Gln Met Val Leu Gly Glu 
            180                 185                 190         


Pro Arg Pro Glu Glu Pro Arg Gly Asp Gln Pro His Ser Phe Phe Pro 
        195                 200                 205             


Glu Ser Gln Leu Arg Ala Lys Leu Lys Cys Pro Gly Gly Ser Cys Thr 
    210                 215                 220                 


Pro Gly Leu Lys Lys Ile Gly Ser Leu Lys Val Ser Cys Glu Glu Phe 
225                 230                 235                 240 


Leu Leu Met Gly Leu Arg Tyr Gln His Leu Asp Pro Pro Ser Pro Asn 
                245                 250                 255     


Ile Asp Tyr Ile Ser Ile Gln Leu Asp Leu Thr Asp Thr Arg Ser Lys 
            260                 265                 270         


Ile Val Tyr Lys Ser Glu Ser Ala Trp Leu Pro Val Tyr Ile Arg Ala 
        275                 280                 285             


Gly Ile Pro Asn Gln Ile Pro Lys Ala Ala Phe Met Ala Val Phe Ile 
    290                 295                 300                 


Leu Glu Val Asp Gln Phe Ile Leu Thr Ser Leu Thr Thr Ser Val Leu 
305                 310                 315                 320 


Asp Cys Glu Glu Asp Glu Thr Pro Lys Pro Leu Leu Val Phe Asn Ile 
                325                 330                 335     


Thr Lys Ala Pro Leu Gln Gly Tyr Val Thr His Leu Leu Asp His Thr 
            340                 345                 350         


Arg Pro Ile Ser Ser Phe Thr Trp Lys Asp Leu Ser Asp Met Gln Ile 
        355                 360                 365             


Ala Tyr Gln Pro Pro Asn Ser Ser His Ser Glu Arg Arg His Asp Glu 
    370                 375                 380                 


Val Glu Leu Glu Val Tyr Asp Phe Phe Phe Glu Arg Ser Ala Pro Met 
385                 390                 395                 400 


Thr Val His Ile Ser Ile Arg Thr Ala Asp Thr Asn Ala Pro Arg Val 
                405                 410                 415     


Ser Trp Asn Thr Gly Leu Ser Leu Leu Glu Gly Gln Ser Arg Ala Ile 
            420                 425                 430         


Thr Trp Glu Gln Phe Gln Val Val Asp Asn Asp Asp Ile Gly Ala Val 
        435                 440                 445             


Arg Leu Val Thr Val Gly Gly Leu Gln His Gly Trp Leu Thr Leu Arg 
    450                 455                 460                 


Gly Gly Lys Gly Phe Leu Phe Thr Val Ala Asp Leu Gln Ala Gly Val 
465                 470                 475                 480 


Val Arg Tyr His His Asp Asp Ser Asp Ser Thr Lys Asp Phe Val Val 
                485                 490                 495     


Phe Arg Ile Phe Asp Gly His His Ser Ile Arg His Lys Phe Pro Ile 
            500                 505                 510         


Asn Val Leu Pro Lys Asp Asp Ser Pro Pro Phe Leu Ile Thr Asn Val 
        515                 520                 525             


Val Ile Glu Leu Glu Glu Gly Gln Thr Ile Leu Ile Gln Gly Ser Met 
    530                 535                 540                 


Leu Arg Ala Ser Asp Val Asp Ala Ser Asp Asp Tyr Ile Phe Phe Asn 
545                 550                 555                 560 


Ile Thr Lys Pro Pro Gln Ala Gly Glu Ile Met Lys Lys Pro Gly Pro 
                565                 570                 575     


Gly Leu Ile Gly Tyr Pro Val His Gly Phe Leu Gln Arg Asp Leu Phe 
            580                 585                 590         


Asn Gly Ile Ile Tyr Tyr Arg His Phe Gly Gly Glu Ile Phe Glu Asp 
        595                 600                 605             


Ser Phe Gln Phe Val Leu Trp Asp Ser His Glu Pro Pro Asn Leu Ser 
    610                 615                 620                 


Val Pro Gln Val Ala Thr Ile His Ile Thr Pro Val Asp Asp Gln Leu 
625                 630                 635                 640 


Pro Lys Glu Ala Pro Gly Val Ser Arg His Leu Val Val Lys Glu Thr 
                645                 650                 655     


Glu Val Ala Tyr Ile Thr Lys Lys Gln Leu His Phe Ile Asp Ser Glu 
            660                 665                 670         


Ser Tyr Asp Arg Glu Leu Val Tyr Thr Ile Thr Thr Pro Pro Phe Phe 
        675                 680                 685             


Ser Phe Ser His Arg His Leu Asp Ala Gly Lys Leu Phe Met Val Asp 
    690                 695                 700                 


Ser Ile Pro Lys Val Val Lys Asn Pro Thr Ala Leu Glu Leu Arg Ser 
705                 710                 715                 720 


Phe Thr Gln His Ala Val Asn Tyr Met Lys Val Ala Tyr Met Pro Pro 
                725                 730                 735     


Met Gln Asp Ile Gly Pro His Cys Arg Asp Val Gln Phe Thr Phe Ser 
            740                 745                 750         


Val Ser Asn Gln His Gly Gly Thr Leu His Gly Ile Cys Phe Asn Ile 
        755                 760                 765             


Thr Ile Leu Pro Val Asp Asn Gln Val Pro Glu Ala Phe Thr Asn Pro 
    770                 775                 780                 


Leu Lys Val Thr Glu Gly Gly Gln Ser Ile Ile Ser Thr Glu His Ile 
785                 790                 795                 800 


Leu Ile Ser Asp Ala Asp Thr Lys Leu Asp Asn Ile Asp Leu Ser Leu 
                805                 810                 815     


Arg Glu Leu Pro Leu His Gly Arg Val Glu Leu Asn Gly Phe Pro Leu 
            820                 825                 830         


Asn Ser Gly Gly Thr Phe Ser Trp Gly Asp Leu His Thr Leu Lys Val 
        835                 840                 845             


Arg Tyr Gln His Asp Gly Thr Glu Val Leu Gln Asp Asp Leu Leu Leu 
    850                 855                 860                 


Glu Val Thr Asp Gly Thr Asn Ser Ala Glu Phe Val Leu His Val Glu 
865                 870                 875                 880 


Val Phe Pro Val Asn Asp Glu Pro Pro Val Leu Lys Ala Asp Leu Met 
                885                 890                 895     


Pro Val Met Asn Cys Ser Glu Gly Gly Glu Val Val Ile Thr Ser Glu 
            900                 905                 910         


Tyr Ile Phe Ala Thr Asp Val Asp Ser Asp Asn Leu Lys Leu Met Phe 
        915                 920                 925             


Val Ile Ala Arg Glu Pro Gln His Gly Val Val Arg Arg Ala Gly Val 
    930                 935                 940                 


Thr Val Asp Gln Phe Ser Gln Arg Asp Val Ile Ser Glu Ala Val Thr 
945                 950                 955                 960 


Tyr Lys His Thr Gly Gly Glu Ile Gly Leu Met Pro Cys Phe Asp Thr 
                965                 970                 975     


Ile Thr Leu Val Val Ser Asp Gly Glu Ala Gly Pro Phe Val Asn Gly 
            980                 985                 990         


Cys Cys Tyr Asn Gly Pro Asn Pro  Ser Val Pro Leu His  Ala Ser Phe 
        995                 1000                 1005             


Pro Val  Tyr Asp Leu Asn Ile  Thr Val Tyr Pro Val  Asp Asn Gln 
    1010                 1015                 1020             


Pro Pro  Ser Ile Ala Ile Gly  Pro Val Phe Val Val  Asp Glu Gly 
    1025                 1030                 1035             


Cys Ser  Thr Ala Leu Thr Val  Asn His Leu Ser Ala  Thr Asp Pro 
    1040                 1045                 1050             


Asp Thr  Ala Ala Asp Asp Leu  Glu Phe Val Leu Val  Ser Pro Pro 
    1055                 1060                 1065             


Gln Phe  Gly Tyr Leu Glu Asn  Ile Leu Pro Ser Val  Gly Phe Glu 
    1070                 1075                 1080             


Lys Ser  Asn Ile Gly Ile Ser  Ile Asp Ser Phe Gln  Trp Lys Asp 
    1085                 1090                 1095             


Met Asn  Ala Phe His Ile Asn  Tyr Val Gln Ser Arg  His Leu Arg 
    1100                 1105                 1110             


Ile Glu  Pro Thr Ala Asp Gln  Phe Thr Val Tyr Val  Thr Asp Gly 
    1115                 1120                 1125             


Lys His  His Ser Leu Glu Ile  Pro Phe Ser Ile Ile  Ile Asn Pro 
    1130                 1135                 1140             


Thr Asn  Asp Glu Ala Pro Asp  Phe Val Val Gln Asn  Ile Thr Val 
    1145                 1150                 1155             


Cys Glu  Gly Gln Met Lys Glu  Leu Asp Ser Ser Ile  Ile Ser Ala 
    1160                 1165                 1170             


Val Asp  Leu Asp Ile Pro Gln  Asp Ala Leu Leu Phe  Ser Ile Thr 
    1175                 1180                 1185             


Gln Lys  Pro Arg His Gly Leu  Leu Ile Asp Arg Gly  Phe Ser Lys 
    1190                 1195                 1200             


Asp Phe  Ser Glu Asn Lys Gln  Pro Ala Asn Pro His  Gln Lys His 
    1205                 1210                 1215             


Ala Pro  Val His Ser Phe Ser  Met Glu Leu Leu Lys  Thr Gly Met 
    1220                 1225                 1230             


Arg Leu  Thr Tyr Met His Asp  Asp Ser Glu Ser Leu  Ala Asp Asp 
    1235                 1240                 1245             


Phe Thr  Ile Gln Leu Ser Asp  Gly Lys His Lys Ile  Leu Lys Thr 
    1250                 1255                 1260             


Ile Ser  Val Glu Val Ile Pro  Val Asn Asp Glu Lys  Pro Met Leu 
    1265                 1270                 1275             


Ser Lys  Lys Ala Glu Ile Ala  Met Asn Met Gly Glu  Thr Arg Ile 
    1280                 1285                 1290             


Ile Ser  Ser Ala Ile Leu Ser  Ala Ile Asp Glu Asp  Ser Pro Arg 
    1295                 1300                 1305             


Glu Lys  Ile Tyr Tyr Val Phe  Glu Arg Leu Pro Gln  Asn Gly Gln 
    1310                 1315                 1320             


Leu Gln  Leu Lys Glu Cys Gln  Leu Arg Cys Gly Ile  
    1325                 1330                 1335 


<210>  5556
<211>  715
<212>  PRT
<213>  Homo Sapiens

<400>  5556

Met Val Thr Gln Glu Ser Met Leu Lys Ala Ala Leu Pro Leu Phe Thr 
1               5                   10                  15      


Arg Phe Ile Ile Ser Asn Gly Leu Arg Thr Glu His Gly Val Phe Glu 
            20                  25                  30          


Ile Thr Leu Glu Thr Val Asp Arg Ala Leu Pro Val Val Thr Arg Asn 
        35                  40                  45              


Lys Gly Leu Arg Leu Ala Gln Gly Ala Val Gly Leu Leu Ser Pro Asp 
    50                  55                  60                  


Leu Leu Gln Leu Thr Asp Pro Asp Thr Pro Ala Glu Asn Leu Thr Phe 
65                  70                  75                  80  


Leu Leu Val Gln Leu Pro Gln His Gly Gln Leu Tyr Leu Trp Gly Thr 
                85                  90                  95      


Gly Leu Leu Gln His Asn Phe Thr Gln Gln Asp Val Asp Ser Lys Asn 
            100                 105                 110         


Val Ala Tyr Arg His Ser Gly Gly Asp Ser Gln Thr Asp Cys Phe Thr 
        115                 120                 125             


Phe Met Ala Thr Asp Gly Thr Asn Gln Gly Phe Ile Val Asn Gly Arg 
    130                 135                 140                 


Val Trp Glu Glu Pro Val Leu Phe Thr Ile Gln Val Asp Gln Leu Asp 
145                 150                 155                 160 


Lys Thr Ala Pro Arg Ile Thr Leu Leu His Ser Pro Ser Gln Val Gly 
                165                 170                 175     


Leu Leu Lys Asn Gly Cys Tyr Gly Ile Tyr Ile Thr Ser Arg Val Leu 
            180                 185                 190         


Lys Ala Ser Asp Pro Asp Thr Glu Asp Asp Gln Ile Ile Phe Lys Ile 
        195                 200                 205             


Leu Gln Gly Pro Lys His Gly His Leu Glu Asn Thr Thr Thr Gly Glu 
    210                 215                 220                 


Phe Ile His Glu Lys Phe Ser Gln Lys Asp Leu Asn Ser Lys Thr Ile 
225                 230                 235                 240 


Leu Tyr Ile Ile Asn Pro Ser Leu Glu Val Asn Ser Asp Thr Val Glu 
                245                 250                 255     


Phe Gln Ile Met Asp Pro Thr Gly Asn Ser Ala Thr Pro Gln Ile Leu 
            260                 265                 270         


Glu Leu Lys Trp Ser His Ile Glu Trp Ser Gln Thr Glu Tyr Glu Val 
        275                 280                 285             


Cys Glu Asn Val Gly Leu Leu Pro Leu Glu Ile Ile Arg Arg Gly Tyr 
    290                 295                 300                 


Ser Met Asp Ser Ala Phe Val Gly Ile Lys Val Asn Gln Val Ser Ala 
305                 310                 315                 320 


Ala Val Gly Lys Asp Phe Thr Val Ile Pro Ser Lys Leu Ile Gln Phe 
                325                 330                 335     


Asp Pro Gly Met Ser Thr Lys Met Trp Asn Ile Ala Ile Thr Tyr Asp 
            340                 345                 350         


Gly Leu Glu Glu Asp Asp Glu Val Phe Glu Val Ile Leu Asn Ser Pro 
        355                 360                 365             


Val Asn Ala Val Leu Gly Thr Lys Thr Lys Ala Ala Val Lys Ile Leu 
    370                 375                 380                 


Asp Ser Lys Gly Gly Gln Cys His Pro Ser Tyr Ser Ser Asn Gln Ser 
385                 390                 395                 400 


Lys His Ser Thr Trp Glu Lys Gly Ile Trp His Leu Leu Pro Pro Gly 
                405                 410                 415     


Ser Ser Ser Ser Thr Thr Ser Gly Ser Phe His Leu Glu Arg Arg Pro 
            420                 425                 430         


Leu Pro Ser Ser Met Gln Leu Ala Val Ile Arg Gly Asp Thr Leu Arg 
        435                 440                 445             


Gly Phe Asp Ser Thr Asp Leu Ser Gln Arg Lys Leu Arg Thr Arg Gly 
    450                 455                 460                 


Asn Gly Lys Thr Val Arg Pro Ser Ser Val Tyr Arg Asn Gly Thr Asp 
465                 470                 475                 480 


Ile Ile Tyr Asn Tyr His Gly Ile Val Ser Leu Lys Leu Glu Asp Asp 
                485                 490                 495     


Ser Phe Pro Thr His Lys Arg Lys Ala Lys Val Ser Ile Ile Ser Gln 
            500                 505                 510         


Pro Gln Lys Thr Ile Lys Val Ala Glu Leu Pro Gln Ala Asp Lys Val 
        515                 520                 525             


Glu Ser Thr Thr Asp Ser His Phe Pro Arg Gln Asp Gln Leu Pro Ser 
    530                 535                 540                 


Phe Pro Lys Asn Cys Thr Leu Glu Leu Lys Gly Leu Phe His Phe Glu 
545                 550                 555                 560 


Glu Gly Ile Gln Lys Leu Tyr Gln Cys Asn Gly Ile Ala Trp Lys Ala 
                565                 570                 575     


Trp Ser Pro Gln Thr Lys Asp Val Glu Asp Lys Ser Cys Pro Ala Gly 
            580                 585                 590         


Trp His Gln His Ser Gly Tyr Cys His Ile Leu Ile Thr Glu Gln Lys 
        595                 600                 605             


Gly Thr Trp Asn Ala Ala Ala Gln Ala Cys Arg Glu Gln Tyr Leu Gly 
    610                 615                 620                 


Asn Leu Val Thr Val Phe Ser Arg Gln His Met Arg Trp Leu Trp Asp 
625                 630                 635                 640 


Ile Gly Gly Arg Lys Ser Phe Trp Ile Gly Leu Asn Asp Gln Val His 
                645                 650                 655     


Ala Gly His Trp Glu Trp Ile Gly Gly Glu Pro Val Ala Phe Thr Asn 
            660                 665                 670         


Gly Arg Arg Gly Pro Ser Gln Arg Ser Lys Leu Gly Lys Ser Cys Val 
        675                 680                 685             


Leu Val Gln Arg Gln Gly Lys Trp Gln Thr Lys Asp Cys Arg Arg Ala 
    690                 695                 700                 


Lys Pro His Asn Tyr Val Cys Ser Arg Lys Leu 
705                 710                 715 


<210>  5557
<211>  2139
<212>  PRT
<213>  Homo Sapiens

<400>  5557

Met Ala Gly Ala Ser Arg His Pro Thr Gly Thr Pro Arg Gln Leu Leu 
1               5                   10                  15      


Val Ala Leu Ala Cys Leu Leu Leu Ser Arg Pro Ala Leu Gln Gly Arg 
            20                  25                  30          


Ala Ser Ser Leu Gly Thr Glu Pro Asp Pro Ala Leu Tyr Leu Pro Ala 
        35                  40                  45              


Arg Gly Ala Leu Asp Gly Thr Arg Pro Asp Gly Pro Ser Val Leu Ile 
    50                  55                  60                  


Ala Asn Pro Gly Leu Arg Val Pro Leu Gly Arg Ser Leu Trp Leu Asp 
65                  70                  75                  80  


Pro Leu Arg Asp Leu Val Ile Gly Val Gln Pro Gly Asp Arg Cys Glu 
                85                  90                  95      


Val Thr Val Leu Asp Ala Leu Pro Arg Leu Lys Gly Ala Leu Ser Pro 
            100                 105                 110         


Arg Arg Phe Pro Cys Thr Phe Gly Pro Arg Gln Val Gln Tyr Thr His 
        115                 120                 125             


Phe Gly Ser His Ser Pro Gly Arg Ala Arg Val Leu Leu Gln Leu Arg 
    130                 135                 140                 


Tyr Asp Ala Pro Thr His Thr Leu Val Leu Pro Phe Thr Leu Ala Val 
145                 150                 155                 160 


Asp Leu Val Phe Ser Gln Leu Glu Leu Val Thr Arg Asn Arg Pro Leu 
                165                 170                 175     


Val Val Glu Lys Leu Arg Ser Trp Ser Arg Ala Ile Asp Arg Arg Val 
            180                 185                 190         


Leu Asp Phe Ala Ser Leu Lys Ser Gly Ala Thr Ala Thr Arg Arg Cys 
        195                 200                 205             


Arg Leu Thr Pro Leu Pro His Glu Asp Gly Pro Leu Pro Lys Tyr Gly 
    210                 215                 220                 


Arg Leu Val Asp Ala Val Gly Ala Pro Leu Pro Arg Gly Lys Gly Val 
225                 230                 235                 240 


Asp Cys Glu Ala Phe Leu Arg Ala Gly Val Arg Tyr Gln His Thr Ala 
                245                 250                 255     


Thr Ser Ser Pro Asn Arg Asp Tyr Val Pro Met Met Val Glu Leu Leu 
            260                 265                 270         


Gly Pro Glu Gly Gln Asp Ala Gly Ser Ala Gly Val Leu Val Arg Glu 
        275                 280                 285             


His Phe Gln Leu Leu Val Arg Ile Arg Gly Gly Ala Glu Asn Thr Pro 
    290                 295                 300                 


Pro Arg Pro Ser Phe Met Ala Thr Met Met Met Glu Val Asp Pro Leu 
305                 310                 315                 320 


Val Leu Thr Ala Leu Thr Pro Asp Ala Leu Ala Ala Glu Asp Val Glu 
                325                 330                 335     


Ser Asp Pro Gly Asp Leu Val Phe Asn Ile Leu Asn Ala Pro Thr His 
            340                 345                 350         


Pro Pro Gly His Pro Gly Gln Gln Gly Tyr Val Val Ser Thr Asp Asp 
        355                 360                 365             


Pro Leu Gly Leu Pro Val Ser Phe Phe Thr Gln Gln Glu Leu Arg Glu 
    370                 375                 380                 


Leu Lys Ile Ala Tyr Gln Pro Pro Ala Glu Asn Ser His Gly Glu Arg 
385                 390                 395                 400 


Leu Phe Gln Leu Glu Leu Glu Val Val Asp Gly Asp Gly Ala Ala Ser 
                405                 410                 415     


Asp Pro Phe Ala Phe Met Val Thr Val Lys Ser Met Asn Thr Leu Val 
            420                 425                 430         


Pro Val Ala Ser His Asn Arg Gly Leu Val Leu Phe Glu Gly Gln Ser 
        435                 440                 445             


Arg Pro Leu Ser Ser Thr His Ser Ile Pro Ile Ser Asp Lys Asp Asn 
    450                 455                 460                 


Leu Glu Glu Val Lys Met Ala Ala Val Arg Gly Leu Arg His Gly Gln 
465                 470                 475                 480 


Leu Val Val Phe Gly Ala Pro Ala Gly Cys Lys Tyr Phe Thr Pro Ala 
                485                 490                 495     


Asp Leu Ala Ala Gly Arg Val Val Tyr Gln His Asp Gly Ser Asn Thr 
            500                 505                 510         


Tyr Ser Asp Asn Ile Ile Phe Arg Met Glu Asp Gly His His Gln Val 
        515                 520                 525             


Asp Phe Leu Phe Pro Leu Thr Ile Leu Pro Val Asp Asp Glu Pro Pro 
    530                 535                 540                 


Met Val Asn Thr Asn Thr Gly Leu Ser Leu Thr Glu Gly Gln Val Val 
545                 550                 555                 560 


Gln Ile Ser Pro Phe Val Leu Ser Ala Thr Asp Ile Asp Ser Glu Asp 
                565                 570                 575     


Ser Thr Ile His Phe Val Leu Glu Asn Gln Pro Leu Lys Gly Asn Glu 
            580                 585                 590         


Glu Glu Pro Gln Trp Glu Leu Ala Pro Gly Ser Ser His Ser Gly His 
        595                 600                 605             


Tyr Leu Gly Asp Leu Leu Leu Gln Gln Ala Glu Leu Pro Leu Ser Thr 
    610                 615                 620                 


Glu Asp Glu Asp Trp His Tyr Met Glu Lys Glu Gly Leu Tyr Glu Lys 
625                 630                 635                 640 


Val Val Thr Glu Trp Leu Gln Arg Asp Ile Met Glu Gly Arg Leu Phe 
                645                 650                 655     


Tyr Arg His Leu Gly Pro His Ser Pro Gln Ser Val Met Val Gln Leu 
            660                 665                 670         


Ala Phe His Val Gln Asp Asp His Asp Pro Pro Asn Leu Ser Lys Gln 
        675                 680                 685             


His Ile Phe Thr Ile Lys Val Gln Pro Val Asp Ile Leu Ser Pro Gln 
    690                 695                 700                 


Leu Tyr Pro Gly Thr Thr Leu Glu Met Thr Val Gln Glu Tyr Gln Leu 
705                 710                 715                 720 


Thr His Phe Gln Lys Asn Phe Leu Arg Tyr Ile Asp Gln Asp Ser Asp 
                725                 730                 735     


Asp Gln Asn Leu Trp Tyr Thr Leu Leu Thr Leu Pro Thr Asp Thr Asp 
            740                 745                 750         


Gly Asn His Gln Val Arg Ala Gly Glu Ile Val Leu Thr Asp Ser Pro 
        755                 760                 765             


Asp Thr Leu Ile Met His Phe Thr Gln Ala Gln Val Asn Gln His Lys 
    770                 775                 780                 


Val Ala Tyr Gln Pro Pro Gln Lys Leu Gly Ile Ala Pro Arg Val Val 
785                 790                 795                 800 


Gln Phe Thr Tyr Gln Val Glu Asp Ala Ala Gly Asn Ser Val Pro Gly 
                805                 810                 815     


Thr Phe Thr Leu Phe Leu Gln Pro Val Asp Asn Gln Pro Pro Glu Val 
            820                 825                 830         


Thr Asn Arg Gly Phe Ala Ile Leu Glu Gly Gly Ser Phe Asn Leu Ser 
        835                 840                 845             


Ser Asn Glu Leu His Val Thr Asp Pro Asp Thr Asp Ile Asp Gln Ile 
    850                 855                 860                 


Val Phe Ile Leu Val Arg Gly Pro Gln His Gly His Leu Gln Tyr Phe 
865                 870                 875                 880 


Lys Arg Cys Met Val Pro Gly Glu Ser Phe Met Gln Ala Asp Val Ile 
                885                 890                 895     


Asn Gly Ser Val Ser Tyr Gln His Gly Arg Asp Gln Thr Thr Thr Ser 
            900                 905                 910         


Asp Thr Phe His Leu Glu Val Ser Asp Gly Val His His Ile Pro Ile 
        915                 920                 925             


Thr Ile Pro Ile Ser Val His Pro Asn Val Ala Asn Arg Ser Pro Arg 
    930                 935                 940                 


Ile Ser Leu Arg Ser Ser Ser Leu Leu Asp Val Ser Ile Asp Val Leu 
945                 950                 955                 960 


Glu Asn Lys Ala Thr Glu Ile Thr Met Gly Val Ile His Gly Lys Arg 
                965                 970                 975     


Lys Asp Val Gly Asp Leu Met Leu Ser Phe Ile Val Lys Asp Ser Pro 
            980                 985                 990         


Lys Leu Gly Thr Ile Leu Val Asn  Gly Leu Pro Thr Glu  Arg Phe Thr 
        995                 1000                 1005             


Gln Glu  Asp Leu Ile Asn Gly  Arg Val Ala Tyr Ala  His Thr Ala 
    1010                 1015                 1020             


Gly Glu  Val Gly Phe Gln Lys  Gln His Asp Ala Phe  Ser Leu Ile 
    1025                 1030                 1035             


Leu Ser  Lys Asp Ser Tyr Gln  Trp Val Val Gly Asn  Ser Ile Ile 
    1040                 1045                 1050             


Glu Lys  Val Gln Val Gln Val  Thr Val Leu Pro Val  Asp Asn Val 
    1055                 1060                 1065             


Gly Pro  Lys Val Phe Val Gly  Glu Ser Phe Ile Val  Tyr Glu Gly 
    1070                 1075                 1080             


Glu Lys  Asn Ser Leu Thr Leu  Gln His Leu His Val  Glu Asp Val 
    1085                 1090                 1095             


Asp Thr  His Gln Asp Glu Leu  Leu Cys Thr Val Thr  Ser Gln Pro 
    1100                 1105                 1110             


Ala Ser  Gly Tyr Leu Glu Lys  Ile Ala Ser Ala Pro  Gly Ser Lys 
    1115                 1120                 1125             


Met Ser  Gln Ser Gly Ser Pro  Ile Ser Ala Phe Ser  Leu Arg Asp 
    1130                 1135                 1140             


Ile Gln  Val Arg His Ile Asn  Tyr Val Gln Ser Ile  His Lys Gly 
    1145                 1150                 1155             


Val Glu  Pro Gln Glu Asp Gln  Phe Thr Phe Tyr Cys  Ser Asp Gly 
    1160                 1165                 1170             


Ile Asn  Phe Ser Pro Asn Val  Phe Phe Pro Ile Ile  Ile Leu Pro 
    1175                 1180                 1185             


Thr Asn  Asp Glu Gln Pro Lys  Leu Phe Ala His Glu  Phe Lys Val 
    1190                 1195                 1200             


Leu Glu  Gly Met Ser Leu Val  Ile Asp Thr Gln Leu  Leu Asn Gly 
    1205                 1210                 1215             


Ala Asp  Ala Asp Leu Pro Pro  Asn Glu Leu His Phe  Gln Leu Thr 
    1220                 1225                 1230             


Ala Leu  Pro Arg His Gly Arg  Ile Ile Gln Gln Leu  Ala Thr Gly 
    1235                 1240                 1245             


Ser Gln  Pro Ile His Ser Phe  Thr Leu Lys Glu Ile  Gln Glu Ala 
    1250                 1255                 1260             


Ser Thr  Ile Val Tyr Glu His  Asp Asp Ser Glu Thr  Lys Glu Asp 
    1265                 1270                 1275             


Ser Phe  Glu Val Trp Leu Ser  Asp Gly Lys His Thr  Thr His Arg 
    1280                 1285                 1290             


Lys Val  Pro Ile Val Val Thr  Leu Val Asp Asp Glu  Thr Pro His 
    1295                 1300                 1305             


Leu Thr  Val Asn Asn Gly Leu  Lys Val Glu Lys Gly  His Ser Glu 
    1310                 1315                 1320             


Ile Ile  Thr Asn Arg Ile Leu  Lys Ala Thr Asp Leu  Asp Ser Asp 
    1325                 1330                 1335             


Asp Lys  Ser Leu Ser Phe Val  Leu His Ser Gly Pro  Gln Gln Gly 
    1340                 1345                 1350             


Leu Leu  Gln Arg Leu Arg Lys  Pro Arg Gly Glu Val  Arg Asn Asn 
    1355                 1360                 1365             


Leu Thr  Leu Gly Met Asn Phe  Thr Gln Asp Glu Ile  Asn Arg Gly 
    1370                 1375                 1380             


Leu Ile  Cys Tyr Ile His Thr  Gly Gln Glu Gly Ile  Val Asp Ile 
    1385                 1390                 1395             


Ile Lys  Phe Asp Val Thr Asp  Gly Val Asn Thr Leu  Thr Asp His 
    1400                 1405                 1410             


Tyr Phe  Tyr Val Thr Ile Gly  Asn Leu Asp Ser Val  Phe Pro Glu 
    1415                 1420                 1425             


Val Ile  Ser Lys Arg Ile Thr  Leu Ile Glu Gly Ala  Arg Val Thr 
    1430                 1435                 1440             


Leu Thr  Asn Asn Leu Leu Thr  Asn Ser Asp Ile Asn  Ser Ser Asp 
    1445                 1450                 1455             


Glu His  His Phe Ser Ile Thr  Arg Ala Pro Ser Leu  Gly His Leu 
    1460                 1465                 1470             


Glu Ser  Ser Asp Tyr Ala Gly  Glu Pro Ile Ala Ser  Phe Thr Gln 
    1475                 1480                 1485             


Leu Gln  Leu Ala Ser Asn Lys  Ile Ser Tyr Val His  Thr Ser Asn 
    1490                 1495                 1500             


Asp Glu  Lys Lys Met Asp Ser  Phe Glu Phe Gln Val  Ile Gly Glu 
    1505                 1510                 1515             


Leu Tyr  Pro Val Phe Arg Thr  Phe Arg Ile Phe Ile  Thr Asp Val 
    1520                 1525                 1530             


Asp Asn  Lys Lys Pro Ile Leu  Thr Ile His Arg Leu  Thr Leu Gln 
    1535                 1540                 1545             


Lys Glu  Asp Ser Gln Leu Ile  Thr Leu Leu Glu Leu  Thr Val Glu 
    1550                 1555                 1560             


Asp Ser  Asp Thr Pro Asp Asp  Leu Ile Leu Phe Thr  Ile Thr Gln 
    1565                 1570                 1575             


Val Pro  Met His Gly Lys Ile  Leu Tyr Asn Gly Ser  Arg Pro Val 
    1580                 1585                 1590             


Thr Thr  Phe Thr Lys Gln Asp  Leu Asn Lys Asn Leu  Ile Ser Tyr 
    1595                 1600                 1605             


Lys His  Asp Gly Ser Glu Thr  Thr Glu Asp Ser Phe  Ser Leu Thr 
    1610                 1615                 1620             


Val Thr  Asp Gly Thr His Thr  Asp Phe Tyr Val Leu  Pro Asp Thr 
    1625                 1630                 1635             


Ala Leu  Ala Thr His Lys Pro  Gln Val Met Arg Val  Gln Ile Arg 
    1640                 1645                 1650             


Ser Leu  Asp Asn Arg Leu Pro  Gln Ile Thr Thr Asn  Arg Gly Ala 
    1655                 1660                 1665             


Pro Ala  Leu Lys Arg Leu His  Thr Gly His Met Gly  Phe Leu Ile 
    1670                 1675                 1680             


Thr Ser  Lys Ser Leu Lys Ala  Glu Asp Gln Asp Ser  Pro His Arg 
    1685                 1690                 1695             


Leu Leu  Lys Tyr Lys Val Thr  Arg Gly Pro Glu His  Gly Phe Ile 
    1700                 1705                 1710             


Ile Lys  Thr Gly Leu Gly Asn  Gln Ser Thr Arg Val  Phe Thr Gln 
    1715                 1720                 1725             


Ala Asp  Ile Asp Glu Met Lys  Ile Ser Tyr Val Leu  Asn Glu Gly 
    1730                 1735                 1740             


Ser Asn  Ala Ser Lys Asp Ile  Phe Tyr Phe Ser Val  Glu Asp Asn 
    1745                 1750                 1755             


Gly Gly  Asn Lys Leu Thr Asn  Gln Pro Phe His Leu  Asn Trp Ala 
    1760                 1765                 1770             


Trp Ile  Cys Leu Glu Lys Glu  Tyr Tyr Ile Val Asp  Glu Asp Ser 
    1775                 1780                 1785             


Thr Phe  Leu Glu Val Thr Leu  Thr Arg Arg Gly Tyr  Leu Gly Glu 
    1790                 1795                 1800             


Thr Ser  Phe Ile Ser Ile Gly  Thr Lys Asp Glu Thr  Ala Lys Lys 
    1805                 1810                 1815             


Asp Lys  Asp Phe Lys Trp Lys  Thr Asn Lys Gln Ile  Gln Phe Asn 
    1820                 1825                 1830             


Pro Gly  Gln Thr Thr Ala Thr  Trp Arg Val Arg Ile  Ile Pro Asp 
    1835                 1840                 1845             


Asn Glu  Tyr Glu Thr Ser Glu  Thr Phe Gln Ile Ile  Leu Ser Glu 
    1850                 1855                 1860             


Pro Leu  Met Ala Val Leu Glu  Phe Pro Glu Met Ala  Thr Val Glu 
    1865                 1870                 1875             


Ile Val  Asp Pro Gly Asp Glu  Ser Thr Val Tyr Ile  Pro Glu Ala 
    1880                 1885                 1890             


Glu Tyr  Lys Ile Glu Glu Asp  Ile Gly Glu Leu Leu  Ile Pro Val 
    1895                 1900                 1905             


Arg Arg  Ser Gly Asp Ala Ser  Gln Glu Leu Ile Val  Ile Cys Ser 
    1910                 1915                 1920             


Thr Arg  Gln Gly Ser Ala Thr  Gly Thr Ile Ser Ser  Thr Val Leu 
    1925                 1930                 1935             


Phe Ser  Asp Tyr Ile Ser Arg  Pro Glu Asp His Thr  Ser Ile Leu 
    1940                 1945                 1950             


His Phe  Asp Lys Asn Glu Thr  Gln Lys Thr Cys Gln  Val Leu Ile 
    1955                 1960                 1965             


Ile Asp  Asp Ser Leu Tyr Glu  Glu Glu Glu Ser Phe  Ser Val Ser 
    1970                 1975                 1980             


Leu Arg  Leu Pro Val Gly Gly  Gln Leu Gly Ala Arg  Phe Pro Thr 
    1985                 1990                 1995             


Thr Lys  Val Thr Ile Leu Ala  Asp Arg Tyr Asp Glu  Pro Val Leu 
    2000                 2005                 2010             


His Phe  Gly Asp Ala Glu Tyr  His Val Asn Glu Ser  Ala Arg Tyr 
    2015                 2020                 2025             


Val Glu  Val Cys Val Trp Arg  Arg Gly Thr Asp Leu  Ser Gln Pro 
    2030                 2035                 2040             


Ser Ser  Ile Ala Val Arg Ser  Arg Lys Ser Glu Gln  Glu Ser Ala 
    2045                 2050                 2055             


Glu Ala  Gly Thr Asp Tyr Val  Gly Ile Ser Arg Asn  Leu Asp Phe 
    2060                 2065                 2070             


Ala Pro  Gly Val Arg Met Gln  Thr Phe Gln Val Thr  Ile Leu Asp 
    2075                 2080                 2085             


Asp Leu  Gly Gln Pro Thr Leu  Glu Gly Pro Glu Lys  Phe Glu Leu 
    2090                 2095                 2100             


Leu Leu  Gln Met Pro Met Gly  Ala Val Leu Gly Glu  Pro Asn Lys 
    2105                 2110                 2115             


Thr Thr  Ile Phe Ile Glu Asp  Thr Ile Thr Asp Cys  Lys Gln Ser 
    2120                 2125                 2130             


Ala Cys  Ser Ser Phe Asp 
    2135                 


<210>  5558
<211>  1284
<212>  PRT
<213>  Homo Sapiens

<400>  5558

Met His Val Phe Ile Val Gly Met Ser Leu Ser Ser Val Thr Leu Ala 
1               5                   10                  15      


Ser Ala Leu Gln Val Arg Gly Glu Ala Leu Ser Glu Glu Glu Ile Trp 
            20                  25                  30          


Ser Leu Leu Phe Leu Ala Ala Glu Gln Leu Leu Glu Asp Leu Arg Asn 
        35                  40                  45              


Asp Ser Ser Asp Tyr Val Val Cys Pro Trp Ser Ala Leu Leu Ser Ala 
    50                  55                  60                  


Ala Gly Ser Leu Ser Phe Gln Gly Arg Val Ser His Ile Glu Ala Ala 
65                  70                  75                  80  


Pro Phe Lys Ala Pro Glu Leu Leu Gln Gly Gln Ser Glu Asp Glu Gln 
                85                  90                  95      


Pro Asp Ala Ser Gln Pro Leu Gln Leu Cys Glu Pro Leu His Ser Ile 
            100                 105                 110         


Leu Leu Thr Met Cys Glu Asp Gln Pro His Arg Arg Cys Thr Leu Gln 
        115                 120                 125             


Ser Val Leu Glu Ala Cys Arg Val His Glu Lys Glu Val Ser Val Tyr 
    130                 135                 140                 


Pro Ala Pro Ala Gly Leu His Ile Arg Arg Leu Val Gly Leu Val Leu 
145                 150                 155                 160 


Gly Thr Ile Ser Glu Val Glu Lys Arg Val Val Glu Glu Ser Ser Ser 
                165                 170                 175     


Val Gln Gln Asn Arg Ser Tyr Leu Leu Arg Lys Arg Leu Arg Gly Thr 
            180                 185                 190         


Ser Ser Glu Ser Pro Ala Ala Gln Ala Pro Glu Cys Leu His Pro Cys 
        195                 200                 205             


Arg Val Ser Glu Arg Ser Thr Glu Thr Gln Ser Ser Pro Glu Pro His 
    210                 215                 220                 


Trp Ser Thr Leu Thr His Ser His Cys Ser Leu Leu Val Asn Arg Ala 
225                 230                 235                 240 


Leu Pro Gly Ala Asp Pro Gln Asp Gln Gln Ala Gly Arg Arg Leu Ser 
                245                 250                 255     


Ser Gly Ser Val His Ser Ala Ala Asp Ser Ser Trp Pro Thr Thr Pro 
            260                 265                 270         


Ser Gln Arg Gly Phe Leu Gln Arg Arg Ser Lys Phe Ser Arg Pro Glu 
        275                 280                 285             


Phe Ile Leu Leu Ala Gly Glu Ala Pro Met Thr Leu His Leu Pro Gly 
    290                 295                 300                 


Ser Val Val Thr Lys Lys Gly Lys Ser Tyr Leu Ala Leu Arg Asp Leu 
305                 310                 315                 320 


Cys Val Val Leu Leu Asn Gly Gln His Leu Glu Val Lys Cys Asp Val 
                325                 330                 335     


Glu Ser Thr Val Gly Ala Val Phe Asn Ala Val Thr Ser Phe Ala Asn 
            340                 345                 350         


Leu Glu Glu Leu Thr Tyr Phe Gly Leu Ala Tyr Met Lys Ser Lys Glu 
        355                 360                 365             


Phe Phe Phe Leu Asp Ser Glu Thr Arg Leu Cys Lys Ile Ala Pro Glu 
    370                 375                 380                 


Gly Trp Arg Glu Gln Pro Gln Lys Thr Ser Met Asn Thr Phe Thr Leu 
385                 390                 395                 400 


Phe Leu Arg Ile Lys Phe Phe Val Ser His Tyr Gly Leu Leu Gln His 
                405                 410                 415     


Ser Leu Thr Arg His Gln Phe Tyr Leu Gln Leu Arg Lys Asp Ile Leu 
            420                 425                 430         


Glu Glu Arg Leu Tyr Cys Asn Glu Glu Ile Leu Leu Gln Leu Gly Val 
        435                 440                 445             


Leu Ala Leu Gln Ala Glu Phe Gly Asn Tyr Pro Lys Glu Val Glu Ser 
    450                 455                 460                 


Lys Pro Tyr Phe His Val Glu Asp Tyr Ile Pro Ala Ser Leu Ile Glu 
465                 470                 475                 480 


Arg Met Thr Ala Leu Arg Val Gln Val Glu Val Ser Glu Met His Arg 
                485                 490                 495     


Leu Ser Ser Ala Leu Trp Gly Glu Asp Ala Glu Leu Lys Phe Leu Arg 
            500                 505                 510         


Val Thr Gln Gln Leu Pro Glu Tyr Gly Val Leu Val His Gln Val Phe 
        515                 520                 525             


Ser Glu Lys Arg Arg Pro Glu Glu Glu Met Ala Leu Gly Ile Cys Ala 
    530                 535                 540                 


Lys Gly Val Ile Val Tyr Glu Val Lys Asn Asn Ser Arg Ile Ala Met 
545                 550                 555                 560 


Leu Arg Phe Gln Trp Arg Glu Thr Gly Lys Ile Ser Thr Tyr Gln Lys 
                565                 570                 575     


Lys Phe Thr Ile Thr Ser Ser Val Thr Gly Lys Lys His Thr Phe Val 
            580                 585                 590         


Thr Asp Ser Ala Lys Thr Ser Lys Tyr Leu Leu Asp Leu Cys Ser Ala 
        595                 600                 605             


Gln His Gly Phe Asn Ala Gln Met Gly Ser Gly Gln Pro Ser His Val 
    610                 615                 620                 


Leu Phe Asp His Asp Lys Phe Val Gln Met Ala Asn Leu Ser Pro Ala 
625                 630                 635                 640 


His Gln Ala Arg Ser Lys Pro Leu Ile Trp Ile Gln Arg Leu Ser Cys 
                645                 650                 655     


Ser Glu Asn Glu Leu Phe Val Ser Arg Leu Gln Gly Ala Ala Gly Gly 
            660                 665                 670         


Leu Leu Ser Thr Ser Met Asp Asn Phe Asn Val Asp Gly Ser Lys Glu 
        675                 680                 685             


Ala Gly Ala Glu Gly Ile Gly Arg Ser Pro Cys Thr Gly Arg Glu Gln 
    690                 695                 700                 


Leu Lys Ser Ala Cys Val Ile Gln Lys Pro Met Thr Trp Asp Ser Leu 
705                 710                 715                 720 


Ser Gly Pro Pro Val Gln Ser Met His Ala Gly Ser Lys Asn Asn Arg 
                725                 730                 735     


Arg Lys Ser Phe Ile Ala Glu Pro Gly Arg Glu Ile Val Arg Val Thr 
            740                 745                 750         


Leu Lys Arg Asp Pro His Arg Gly Phe Gly Phe Val Ile Asn Glu Gly 
        755                 760                 765             


Glu Tyr Ser Gly Gln Ala Asp Pro Gly Ile Phe Ile Ser Ser Ile Ile 
    770                 775                 780                 


Pro Gly Gly Pro Ala Glu Lys Ala Lys Thr Ile Lys Pro Gly Gly Gln 
785                 790                 795                 800 


Ile Leu Ala Leu Asn His Ile Ser Leu Glu Gly Phe Thr Phe Asn Met 
                805                 810                 815     


Ala Val Arg Met Ile Gln Asn Ser Pro Asp Asn Ile Glu Leu Ile Ile 
            820                 825                 830         


Ser Gln Ser Lys Gly Val Gly Gly Asn Asn Pro Asp Glu Glu Lys Asn 
        835                 840                 845             


Ser Thr Ala Asn Ser Gly Val Ser Ser Thr Asp Ile Leu Ser Phe Gly 
    850                 855                 860                 


Tyr Gln Gly Ser Leu Leu Ser His Thr Gln Asp Gln Asp Arg Asn Thr 
865                 870                 875                 880 


Glu Glu Leu Asp Met Ala Gly Val Gln Ser Leu Val Pro Arg Leu Arg 
                885                 890                 895     


His Gln Leu Ser Phe Leu Pro Leu Lys Gly Ala Gly Ser Ser Cys Pro 
            900                 905                 910         


Pro Ser Pro Pro Glu Ile Ser Ala Gly Glu Ile Tyr Phe Val Glu Leu 
        915                 920                 925             


Val Lys Glu Asp Gly Thr Leu Gly Phe Ser Val Thr Gly Gly Ile Asn 
    930                 935                 940                 


Thr Ser Val Pro Tyr Gly Gly Ile Tyr Val Lys Ser Ile Val Pro Gly 
945                 950                 955                 960 


Gly Pro Ala Ala Lys Glu Gly Gln Ile Leu Gln Gly Asp Arg Leu Leu 
                965                 970                 975     


Gln Val Asp Gly Val Ile Leu Cys Gly Leu Thr His Lys Gln Ala Val 
            980                 985                 990         


Gln Cys Leu Thr Gly Pro Gly Gln  Val Ala Arg Leu Val  Leu Glu Arg 
        995                 1000                 1005             


Arg Val  Pro Arg Ser Thr Gln  Gln Cys Pro Ser Ala  Asn Asp Ser 
    1010                 1015                 1020             


Met Gly  Asp Glu Arg Thr Ala  Val Ser Leu Val Thr  Ala Leu Pro 
    1025                 1030                 1035             


Gly Arg  Pro Ser Ser Cys Val  Ser Val Thr Asp Gly  Pro Lys Phe 
    1040                 1045                 1050             


Glu Val  Lys Leu Lys Lys Asn  Ala Asn Gly Leu Gly  Phe Ser Phe 
    1055                 1060                 1065             


Val Gln  Met Glu Lys Glu Ser  Cys Ser His Leu Lys  Ser Asp Leu 
    1070                 1075                 1080             


Val Arg  Ile Lys Arg Leu Phe  Pro Gly Gln Pro Ala  Glu Glu Asn 
    1085                 1090                 1095             


Gly Ala  Ile Ala Ala Gly Asp  Ile Ile Leu Ala Val  Asn Gly Arg 
    1100                 1105                 1110             


Ser Thr  Glu Gly Leu Ile Phe  Gln Glu Val Leu His  Leu Leu Arg 
    1115                 1120                 1125             


Gly Ala  Pro Gln Glu Val Thr  Leu Leu Leu Cys Arg  Pro Pro Pro 
    1130                 1135                 1140             


Gly Ala  Leu Pro Glu Leu Glu  Gln Glu Trp Gln Thr  Pro Glu Leu 
    1145                 1150                 1155             


Ser Ala  Asp Lys Glu Phe Thr  Arg Ala Thr Cys Thr  Asp Ser Cys 
    1160                 1165                 1170             


Thr Ser  Pro Ile Leu Asp Gln  Glu Asp Ser Trp Arg  Asp Ser Ala 
    1175                 1180                 1185             


Ser Pro  Asp Ala Gly Glu Gly  Leu Gly Leu Arg Pro  Glu Ser Ser 
    1190                 1195                 1200             


Gln Lys  Ala Ile Arg Glu Ala  Gln Trp Gly Gln Asn  Arg Glu Arg 
    1205                 1210                 1215             


Pro Trp  Ala Ser Ser Leu Thr  His Ser Pro Glu Ser  His Pro His 
    1220                 1225                 1230             


Leu Cys  Lys Leu His Gln Glu  Arg Asp Glu Ser Thr  Leu Ala Thr 
    1235                 1240                 1245             


Ser Leu  Glu Lys Asp Val Arg  Gln Asn Cys Tyr Ser  Val Cys Asp 
    1250                 1255                 1260             


Ile Met  Arg Leu Gly Arg Tyr  Ser Phe Ser Ser Pro  Leu Thr Arg 
    1265                 1270                 1275             


Leu Ser  Thr Asp Ile Phe 
    1280                 


<210>  5559
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  5559

Met Gln Pro Leu Thr Lys Asp Ala Gly Met Ser Leu Ser Ser Val Thr 
1               5                   10                  15      


Leu Ala Ser Ala Leu Gln Val Arg Gly Glu Ala Leu Ser Glu Glu Glu 
            20                  25                  30          


Ile Trp Ser Leu Leu Phe Leu Ala Ala Glu Gln Leu Leu Glu Asp Leu 
        35                  40                  45              


Arg Asn Ala Pro Ala Ala Leu Arg Ala Pro Ala Leu His Pro Ala Asp 
    50                  55                  60                  


His Val 
65      


<210>  5560
<211>  1309
<212>  PRT
<213>  Homo Sapiens

<400>  5560

Met Gln Pro Leu Thr Lys Asp Ala Gly Met Ser Leu Ser Ser Val Thr 
1               5                   10                  15      


Leu Ala Ser Ala Leu Gln Val Arg Gly Glu Ala Leu Ser Glu Glu Glu 
            20                  25                  30          


Ile Trp Ser Leu Leu Phe Leu Ala Ala Glu Gln Leu Leu Glu Asp Leu 
        35                  40                  45              


Arg Asn Asp Ser Ser Asp Tyr Val Val Cys Pro Trp Ser Ala Leu Leu 
    50                  55                  60                  


Ser Ala Ala Gly Ser Leu Ser Phe Gln Gly Arg Val Ser His Ile Glu 
65                  70                  75                  80  


Ala Ala Pro Phe Lys Ala Pro Glu Leu Leu Gln Gly Gln Ser Glu Asp 
                85                  90                  95      


Glu Gln Pro Asp Ala Ser Gln Met His Val Tyr Ser Leu Gly Met Thr 
            100                 105                 110         


Leu Tyr Trp Ser Ala Gly Phe His Val Pro Pro His Gln Pro Leu Gln 
        115                 120                 125             


Leu Cys Glu Pro Leu His Ser Ile Leu Leu Thr Met Cys Glu Asp Gln 
    130                 135                 140                 


Pro His Arg Arg Cys Thr Leu Gln Ser Val Leu Glu Ala Cys Arg Val 
145                 150                 155                 160 


His Glu Lys Glu Val Ser Val Tyr Pro Ala Pro Ala Gly Leu His Ile 
                165                 170                 175     


Arg Arg Leu Val Gly Leu Val Leu Gly Thr Ile Ser Glu Val Glu Lys 
            180                 185                 190         


Arg Val Val Glu Glu Ser Ser Ser Val Gln Gln Asn Arg Ser Tyr Leu 
        195                 200                 205             


Leu Arg Lys Arg Leu Arg Gly Thr Ser Ser Glu Ser Pro Ala Ala Gln 
    210                 215                 220                 


Ala Pro Glu Cys Leu His Pro Cys Arg Val Ser Glu Arg Ser Thr Glu 
225                 230                 235                 240 


Thr Gln Ser Ser Pro Glu Pro His Trp Ser Thr Leu Thr His Ser His 
                245                 250                 255     


Cys Ser Leu Leu Val Asn Arg Ala Leu Pro Gly Ala Asp Pro Gln Asp 
            260                 265                 270         


Gln Gln Ala Gly Arg Arg Leu Ser Ser Gly Ser Val His Ser Ala Ala 
        275                 280                 285             


Asp Ser Ser Trp Pro Thr Thr Pro Ser Gln Arg Gly Phe Leu Gln Arg 
    290                 295                 300                 


Arg Ser Lys Phe Ser Arg Pro Glu Phe Ile Leu Leu Ala Gly Glu Ala 
305                 310                 315                 320 


Pro Met Thr Leu His Leu Pro Gly Ser Val Val Thr Lys Lys Gly Lys 
                325                 330                 335     


Ser Tyr Leu Ala Leu Arg Asp Leu Cys Val Val Leu Leu Asn Gly Gln 
            340                 345                 350         


His Leu Glu Val Lys Cys Asp Val Glu Ser Thr Val Gly Ala Val Phe 
        355                 360                 365             


Asn Ala Val Thr Ser Phe Ala Asn Leu Glu Glu Leu Thr Tyr Phe Gly 
    370                 375                 380                 


Leu Ala Tyr Met Lys Ser Lys Glu Phe Phe Phe Leu Asp Ser Glu Thr 
385                 390                 395                 400 


Arg Leu Cys Lys Ile Ala Pro Glu Gly Trp Arg Glu Gln Pro Gln Lys 
                405                 410                 415     


Thr Ser Met Asn Thr Phe Thr Leu Phe Leu Arg Ile Lys Phe Phe Val 
            420                 425                 430         


Ser His Tyr Gly Leu Leu Gln His Ser Leu Thr Arg His Gln Phe Tyr 
        435                 440                 445             


Leu Gln Leu Arg Lys Asp Ile Leu Glu Glu Arg Leu Tyr Cys Asn Glu 
    450                 455                 460                 


Glu Ile Leu Leu Gln Leu Gly Val Leu Ala Leu Gln Ala Glu Phe Gly 
465                 470                 475                 480 


Asn Tyr Pro Lys Glu Gln Val Glu Ser Lys Pro Tyr Phe His Val Glu 
                485                 490                 495     


Asp Tyr Ile Pro Ala Ser Leu Ile Glu Arg Met Thr Ala Leu Arg Val 
            500                 505                 510         


Gln Val Glu Val Ser Glu Met His Arg Leu Ser Ser Ala Leu Trp Gly 
        515                 520                 525             


Glu Asp Ala Glu Leu Lys Phe Leu Arg Val Thr Gln Gln Leu Pro Glu 
    530                 535                 540                 


Tyr Gly Val Leu Val His Gln Val Phe Ser Glu Lys Arg Arg Pro Glu 
545                 550                 555                 560 


Glu Glu Met Ala Leu Gly Ile Cys Ala Lys Gly Val Ile Val Tyr Glu 
                565                 570                 575     


Val Lys Asn Asn Ser Arg Ile Ala Met Leu Arg Phe Gln Trp Arg Glu 
            580                 585                 590         


Thr Gly Lys Ile Ser Thr Tyr Gln Lys Lys Phe Thr Ile Thr Ser Ser 
        595                 600                 605             


Val Thr Gly Lys Lys His Thr Phe Val Thr Asp Ser Ala Lys Thr Ser 
    610                 615                 620                 


Lys Tyr Leu Leu Asp Leu Cys Ser Ala Gln His Gly Phe Asn Ala Gln 
625                 630                 635                 640 


Met Gly Ser Gly Gln Pro Ser His Val Leu Phe Asp His Asp Lys Phe 
                645                 650                 655     


Val Gln Met Ala Asn Leu Ser Pro Ala His Gln Ala Arg Ser Lys Pro 
            660                 665                 670         


Leu Ile Trp Ile Gln Arg Leu Ser Cys Ser Glu Asn Glu Leu Phe Val 
        675                 680                 685             


Ser Arg Leu Gln Gly Ala Ala Gly Gly Leu Leu Ser Thr Ser Met Asp 
    690                 695                 700                 


Asn Phe Asn Val Asp Gly Ser Lys Glu Ala Gly Ala Glu Gly Ile Gly 
705                 710                 715                 720 


Arg Ser Pro Cys Thr Gly Arg Glu Gln Leu Lys Ser Ala Cys Val Ile 
                725                 730                 735     


Gln Lys Pro Met Thr Trp Asp Ser Leu Ser Gly Pro Pro Val Gln Ser 
            740                 745                 750         


Met His Ala Gly Ser Lys Asn Asn Arg Arg Lys Ser Phe Ile Ala Glu 
        755                 760                 765             


Pro Gly Arg Glu Ile Val Arg Val Thr Leu Lys Arg Asp Pro His Arg 
    770                 775                 780                 


Gly Phe Gly Phe Val Ile Asn Glu Gly Glu Tyr Ser Gly Gln Ala Asp 
785                 790                 795                 800 


Pro Gly Ile Phe Ile Ser Ser Ile Ile Pro Gly Gly Pro Ala Glu Lys 
                805                 810                 815     


Ala Lys Thr Ile Lys Pro Gly Gly Gln Ile Leu Ala Leu Asn His Ile 
            820                 825                 830         


Ser Leu Glu Gly Phe Thr Phe Asn Met Ala Val Arg Met Ile Gln Asn 
        835                 840                 845             


Ser Pro Asp Asn Ile Glu Leu Ile Ile Ser Gln Ser Lys Gly Val Gly 
    850                 855                 860                 


Gly Asn Asn Pro Asp Glu Glu Lys Asn Ser Thr Ala Asn Ser Gly Val 
865                 870                 875                 880 


Ser Ser Thr Asp Ile Leu Ser Phe Gly Tyr Gln Gly Ser Leu Leu Ser 
                885                 890                 895     


His Thr Gln Asp Gln Asp Arg Asn Thr Glu Glu Leu Asp Met Ala Gly 
            900                 905                 910         


Val Gln Ser Leu Val Pro Arg Leu Arg His Gln Leu Ser Phe Leu Pro 
        915                 920                 925             


Leu Lys Gly Ala Gly Ser Ser Cys Pro Pro Ser Pro Pro Glu Ile Ser 
    930                 935                 940                 


Ala Gly Glu Ile Tyr Phe Val Glu Leu Val Lys Glu Asp Gly Thr Leu 
945                 950                 955                 960 


Gly Phe Ser Val Thr Gly Gly Ile Asn Thr Ser Val Pro Tyr Gly Gly 
                965                 970                 975     


Ile Tyr Val Lys Ser Ile Val Pro Gly Gly Pro Ala Ala Lys Glu Gly 
            980                 985                 990         


Gln Ile Leu Gln Gly Asp Arg Leu  Leu Gln Val Asp Gly  Val Ile Leu 
        995                 1000                 1005             


Cys Gly  Leu Thr His Lys Gln  Ala Val Gln Cys Leu  Thr Gly Pro 
    1010                 1015                 1020             


Gly Gln  Val Ala Arg Leu Val  Leu Glu Arg Arg Val  Pro Arg Ser 
    1025                 1030                 1035             


Thr Gln  Gln Cys Pro Ser Ala  Asn Asp Ser Met Gly  Asp Glu Arg 
    1040                 1045                 1050             


Thr Ala  Val Ser Leu Val Thr  Ala Leu Pro Gly Arg  Pro Ser Ser 
    1055                 1060                 1065             


Cys Val  Ser Val Thr Asp Gly  Pro Lys Phe Glu Val  Lys Leu Lys 
    1070                 1075                 1080             


Lys Asn  Ala Asn Gly Leu Gly  Phe Ser Phe Val Gln  Met Glu Lys 
    1085                 1090                 1095             


Glu Ser  Cys Ser His Leu Lys  Ser Asp Leu Val Arg  Ile Lys Arg 
    1100                 1105                 1110             


Leu Phe  Pro Gly Gln Pro Ala  Glu Glu Asn Gly Ala  Ile Ala Ala 
    1115                 1120                 1125             


Gly Asp  Ile Ile Leu Ala Val  Asn Gly Arg Ser Thr  Glu Gly Leu 
    1130                 1135                 1140             


Ile Phe  Gln Glu Val Leu His  Leu Leu Arg Gly Ala  Pro Gln Glu 
    1145                 1150                 1155             


Val Thr  Leu Leu Leu Cys Arg  Pro Pro Pro Gly Ala  Leu Pro Glu 
    1160                 1165                 1170             


Leu Glu  Gln Glu Trp Gln Thr  Pro Glu Leu Ser Ala  Asp Lys Glu 
    1175                 1180                 1185             


Phe Thr  Arg Ala Thr Cys Thr  Asp Ser Cys Thr Ser  Pro Ile Leu 
    1190                 1195                 1200             


Asp Gln  Glu Asp Ser Trp Arg  Asp Ser Ala Ser Pro  Asp Ala Gly 
    1205                 1210                 1215             


Glu Gly  Leu Gly Leu Arg Pro  Glu Ser Ser Gln Lys  Ala Ile Arg 
    1220                 1225                 1230             


Glu Ala  Gln Trp Gly Gln Asn  Arg Glu Arg Pro Trp  Ala Ser Ser 
    1235                 1240                 1245             


Leu Thr  His Ser Pro Glu Ser  His Pro His Leu Cys  Lys Leu His 
    1250                 1255                 1260             


Gln Glu  Arg Asp Glu Ser Thr  Leu Ala Thr Ser Leu  Glu Lys Asp 
    1265                 1270                 1275             


Val Arg  Gln Asn Cys Tyr Ser  Val Cys Asp Ile Met  Arg Leu Gly 
    1280                 1285                 1290             


Arg Tyr  Ser Phe Ser Ser Pro  Leu Thr Arg Leu Ser  Thr Asp Ile 
    1295                 1300                 1305             


Phe 
    


<210>  5561
<211>  1397
<212>  PRT
<213>  Homo Sapiens

<400>  5561

Met Gln Pro Leu Thr Lys Asp Ala Gly Met Ser Leu Ser Ser Val Thr 
1               5                   10                  15      


Leu Ala Ser Ala Leu Gln Val Arg Gly Glu Ala Leu Ser Glu Glu Glu 
            20                  25                  30          


Ile Trp Ser Leu Leu Phe Leu Ala Ala Glu Gln Leu Leu Glu Asp Leu 
        35                  40                  45              


Arg Asn Asp Ser Ser Asp Tyr Val Val Cys Pro Trp Ser Ala Leu Leu 
    50                  55                  60                  


Ser Ala Ala Gly Ser Leu Ser Phe Gln Gly Arg Val Ser His Ile Glu 
65                  70                  75                  80  


Ala Ala Pro Phe Lys Ala Pro Glu Leu Leu Gln Gly Gln Ser Glu Asp 
                85                  90                  95      


Glu Gln Pro Asp Ala Ser Gln Met His Val Tyr Ser Leu Gly Met Thr 
            100                 105                 110         


Leu Tyr Trp Ser Ala Gly Phe His Val Pro Pro His Gln Pro Leu Gln 
        115                 120                 125             


Leu Cys Glu Pro Leu His Ser Ile Leu Leu Thr Met Cys Glu Asp Gln 
    130                 135                 140                 


Pro His Arg Arg Cys Thr Leu Gln Ser Val Leu Glu Ala Cys Arg Val 
145                 150                 155                 160 


His Glu Lys Glu Val Ser Val Tyr Pro Ala Pro Ala Gly Leu His Ile 
                165                 170                 175     


Arg Arg Leu Val Gly Leu Val Leu Gly Thr Ile Ser Glu Val Glu Lys 
            180                 185                 190         


Arg Val Val Glu Glu Ser Ser Ser Val Gln Gln Asn Arg Ser Tyr Leu 
        195                 200                 205             


Leu Arg Lys Arg Leu Arg Gly Thr Ser Ser Glu Ser Pro Ala Ala Gln 
    210                 215                 220                 


Ala Pro Glu Cys Leu His Pro Cys Arg Val Ser Glu Arg Ser Thr Glu 
225                 230                 235                 240 


Thr Gln Ser Ser Pro Glu Pro His Trp Ser Thr Leu Thr His Ser His 
                245                 250                 255     


Cys Ser Leu Leu Val Asn Arg Ala Leu Pro Gly Ala Asp Pro Gln Asp 
            260                 265                 270         


Gln Gln Ala Gly Arg Arg Leu Ser Ser Gly Ser Val His Ser Ala Ala 
        275                 280                 285             


Asp Ser Ser Trp Pro Thr Thr Pro Ser Gln Arg Gly Phe Leu Gln Arg 
    290                 295                 300                 


Arg Ser Lys Phe Ser Arg Pro Glu Phe Ile Leu Leu Ala Gly Glu Ala 
305                 310                 315                 320 


Pro Met Thr Leu His Leu Pro Gly Ser Val Val Thr Lys Lys Gly Lys 
                325                 330                 335     


Ser Tyr Leu Ala Leu Arg Asp Leu Cys Val Val Leu Leu Asn Gly Gln 
            340                 345                 350         


His Leu Glu Val Lys Cys Asp Val Glu Ser Thr Val Gly Ala Val Phe 
        355                 360                 365             


Asn Ala Val Thr Ser Phe Ala Asn Leu Glu Glu Leu Thr Tyr Phe Gly 
    370                 375                 380                 


Leu Ala Tyr Met Lys Ser Lys Glu Phe Phe Phe Leu Asp Ser Glu Thr 
385                 390                 395                 400 


Arg Leu Cys Lys Ile Ala Pro Glu Gly Trp Arg Glu Gln Pro Gln Lys 
                405                 410                 415     


Thr Ser Met Asn Thr Phe Thr Leu Phe Leu Arg Ile Lys Phe Phe Val 
            420                 425                 430         


Ser His Tyr Gly Leu Leu Gln His Ser Leu Thr Arg His Gln Phe Tyr 
        435                 440                 445             


Leu Gln Leu Arg Lys Asp Ile Leu Glu Glu Arg Leu Tyr Cys Asn Glu 
    450                 455                 460                 


Glu Ile Leu Leu Gln Leu Gly Val Leu Ala Leu Gln Ala Glu Phe Gly 
465                 470                 475                 480 


Asn Tyr Pro Lys Glu Gln Val Glu Ser Lys Pro Tyr Phe His Val Glu 
                485                 490                 495     


Asp Tyr Ile Pro Ala Ser Leu Ile Glu Arg Met Thr Ala Leu Arg Val 
            500                 505                 510         


Gln Val Glu Val Ser Glu Met His Arg Leu Ser Ser Ala Leu Trp Gly 
        515                 520                 525             


Glu Asp Ala Glu Leu Lys Phe Leu Arg Val Thr Gln Gln Leu Pro Glu 
    530                 535                 540                 


Tyr Gly Val Leu Val His Gln Val Phe Ser Glu Lys Arg Arg Pro Glu 
545                 550                 555                 560 


Glu Glu Met Ala Leu Gly Ile Cys Ala Lys Gly Val Ile Val Tyr Glu 
                565                 570                 575     


Val Lys Asn Asn Ser Arg Ile Ala Met Leu Arg Phe Gln Trp Arg Glu 
            580                 585                 590         


Thr Gly Lys Ile Ser Thr Tyr Gln Lys Lys Phe Thr Ile Thr Ser Ser 
        595                 600                 605             


Val Thr Gly Lys Lys His Thr Phe Val Thr Asp Ser Ala Lys Thr Ser 
    610                 615                 620                 


Lys Tyr Leu Leu Asp Leu Cys Ser Ala Gln His Gly Phe Asn Ala Gln 
625                 630                 635                 640 


Met Gly Ser Gly Gln Pro Ser His Val Leu Phe Asp His Asp Lys Phe 
                645                 650                 655     


Val Gln Met Ala Asn Leu Ser Pro Ala His Gln Ala Arg Ser Lys Pro 
            660                 665                 670         


Leu Ile Trp Ile Gln Arg Leu Ser Cys Ser Glu Asn Glu Leu Phe Val 
        675                 680                 685             


Ser Arg Leu Gln Gly Ala Ala Gly Gly Leu Leu Ser Thr Ser Met Asp 
    690                 695                 700                 


Asn Phe Asn Val Asp Gly Ser Lys Glu Ala Gly Ala Glu Gly Ile Gly 
705                 710                 715                 720 


Arg Ser Pro Cys Thr Gly Arg Glu Gln Leu Lys Ser Ala Cys Val Ile 
                725                 730                 735     


Gln Lys Pro Met Thr Trp Asp Ser Leu Ser Gly Pro Pro Val Gln Ser 
            740                 745                 750         


Met His Ala Gly Ser Lys Asn Asn Arg Arg Lys Ser Phe Ile Ala Glu 
        755                 760                 765             


Pro Gly Arg Glu Ile Val Arg Val Thr Leu Lys Arg Asp Pro His Arg 
    770                 775                 780                 


Gly Phe Gly Phe Val Ile Asn Glu Gly Glu Tyr Ser Gly Gln Ala Asp 
785                 790                 795                 800 


Pro Gly Ile Phe Ile Ser Ser Ile Ile Pro Gly Gly Pro Ala Glu Lys 
                805                 810                 815     


Ala Lys Thr Ile Lys Pro Gly Gly Gln Ile Leu Ala Leu Asn His Ile 
            820                 825                 830         


Ser Leu Glu Gly Phe Thr Phe Asn Met Ala Val Arg Met Ile Gln Asn 
        835                 840                 845             


Ser Pro Asp Asn Ile Glu Leu Ile Ile Ser Gln Ser Lys Gly Val Gly 
    850                 855                 860                 


Gly Asn Asn Pro Asp Glu Glu Lys Asn Ser Thr Ala Asn Ser Gly Val 
865                 870                 875                 880 


Ser Ser Thr Asp Ile Leu Ser Phe Gly Tyr Gln Gly Ser Leu Leu Ser 
                885                 890                 895     


His Thr Gln Asp Gln Asp Arg Asn Thr Glu Glu Leu Asp Met Ala Gly 
            900                 905                 910         


Val Gln Ser Leu Val Pro Arg Leu Arg His Gln Leu Ser Phe Leu Pro 
        915                 920                 925             


Leu Lys Gly Ala Gly Ser Ser Cys Pro Pro Ser Pro Pro Glu Ile Ser 
    930                 935                 940                 


Ala Gly Glu Ile Tyr Phe Val Glu Leu Val Lys Glu Asp Gly Thr Leu 
945                 950                 955                 960 


Gly Phe Ser Val Thr Gly Gly Ile Asn Thr Ser Val Pro Tyr Gly Gly 
                965                 970                 975     


Ile Tyr Val Lys Ser Ile Val Pro Gly Gly Pro Ala Ala Lys Glu Gly 
            980                 985                 990         


Gln Ile Leu Gln Gly Asp Arg Leu  Leu Gln Val Asp Gly  Val Ile Leu 
        995                 1000                 1005             


Cys Gly  Leu Thr His Lys Gln  Ala Val Gln Cys Leu  Thr Gly Pro 
    1010                 1015                 1020             


Gly Gln  Val Ala Arg Leu Val  Leu Glu Arg Arg Val  Pro Arg Ser 
    1025                 1030                 1035             


Thr Gln  Gln Cys Pro Ser Ala  Asn Asp Ser Met Gly  Asp Glu Arg 
    1040                 1045                 1050             


Thr Ala  Val Ser Leu Val Thr  Ala Leu Pro Gly Arg  Pro Ser Ser 
    1055                 1060                 1065             


Cys Val  Ser Val Thr Asp Gly  Pro Lys Phe Glu Val  Lys Leu Lys 
    1070                 1075                 1080             


Lys Asn  Ala Asn Gly Leu Gly  Phe Ser Phe Val Gln  Met Glu Lys 
    1085                 1090                 1095             


Glu Ser  Cys Ser His Leu Lys  Ser Asp Leu Val Arg  Ile Lys Arg 
    1100                 1105                 1110             


Leu Phe  Pro Gly Gln Pro Ala  Glu Glu Asn Gly Ala  Ile Ala Ala 
    1115                 1120                 1125             


Gly Asp  Ile Ile Leu Ala Val  Asn Gly Arg Ser Thr  Glu Gly Leu 
    1130                 1135                 1140             


Ile Phe  Gln Glu Val Leu His  Leu Leu Arg Gly Ala  Pro Gln Glu 
    1145                 1150                 1155             


Val Thr  Leu Leu Leu Cys Arg  Pro Pro Pro Gly Ala  Leu Pro Glu 
    1160                 1165                 1170             


Leu Glu  Gln Glu Trp Gln Thr  Pro Glu Leu Ser Ala  Asp Lys Glu 
    1175                 1180                 1185             


Phe Thr  Arg Ala Thr Cys Thr  Asp Ser Cys Thr Ser  Pro Ile Leu 
    1190                 1195                 1200             


Asp Gln  Glu Asp Ser Trp Arg  Asp Ser Ala Ser Pro  Asp Ala Gly 
    1205                 1210                 1215             


Glu Gly  Leu Gly Leu Arg Pro  Glu Ser Ser Gln Lys  Ala Ile Arg 
    1220                 1225                 1230             


Glu Ala  Gln Trp Gly Gln Asn  Arg Glu Arg Pro Trp  Ala Ser Ser 
    1235                 1240                 1245             


Leu Thr  His Ser Pro Glu Ser  His Pro His Leu Cys  Lys Leu His 
    1250                 1255                 1260             


Gln Glu  Arg Asp Glu Ser Thr  Leu Ala Thr Ser Leu  Glu Lys Asp 
    1265                 1270                 1275             


Val Arg  Gln Asn Cys Tyr Ser  Val Cys Asp Ile Met  Arg Leu Gly 
    1280                 1285                 1290             


Ser Pro  Glu Leu Asp Gly Glu  Asp Gly Glu Gly Asp  Met Tyr His 
    1295                 1300                 1305             


Pro Cys  Gly Ala Pro Ser Pro  Thr Ser Glu Asp Glu  Glu Tyr Leu 
    1310                 1315                 1320             


Thr Ile  Asn Ser Thr Cys Gln  Gly Gln Leu Pro Cys  Glu Glu Cys 
    1325                 1330                 1335             


Leu Glu  Ala Asp Ser Gly Thr  Ile Pro Leu Pro Gln  Phe Cys Ser 
    1340                 1345                 1350             


Trp Gly  Thr Val Pro Glu Ser  Leu Pro Pro Glu Glu  Ser Pro Glu 
    1355                 1360                 1365             


Ser Gly  Ser Glu Trp Glu Asp  Leu Glu Glu Pro Val  Ala Leu Glu 
    1370                 1375                 1380             


Tyr Gly  Ala Leu Arg Ser Leu  Ser Phe Gly Gly Leu  Asn Val 
    1385                 1390                 1395         


<210>  5562
<211>  325
<212>  PRT
<213>  Homo Sapiens

<400>  5562

Met Val Cys Gly Ser Pro Gly Gly Met Leu Leu Leu Arg Ala Gly Leu 
1               5                   10                  15      


Leu Ala Leu Ala Ala Leu Cys Leu Leu Arg Val Pro Gly Ala Arg Ala 
            20                  25                  30          


Ala Ala Cys Glu Pro Val Arg Ile Pro Leu Cys Lys Ser Leu Pro Trp 
        35                  40                  45              


Asn Met Thr Lys Met Pro Asn His Leu His His Ser Thr Gln Ala Asn 
    50                  55                  60                  


Ala Ile Leu Ala Ile Glu Gln Phe Glu Gly Leu Leu Gly Thr His Cys 
65                  70                  75                  80  


Ser Pro Asp Leu Leu Phe Phe Leu Cys Ala Met Tyr Ala Pro Ile Cys 
                85                  90                  95      


Thr Ile Asp Phe Gln His Glu Pro Ile Lys Pro Cys Lys Ser Val Cys 
            100                 105                 110         


Glu Arg Ala Arg Gln Gly Cys Glu Pro Ile Leu Ile Lys Tyr Arg His 
        115                 120                 125             


Ser Trp Pro Glu Asn Leu Ala Cys Glu Glu Leu Pro Val Tyr Asp Arg 
    130                 135                 140                 


Gly Val Cys Ile Ser Pro Glu Ala Ile Val Thr Ala Asp Gly Ala Asp 
145                 150                 155                 160 


Phe Pro Met Asp Ser Ser Asn Gly Asn Cys Arg Gly Ala Ser Ser Glu 
                165                 170                 175     


Arg Cys Lys Cys Lys Pro Ile Arg Ala Thr Gln Lys Thr Tyr Phe Arg 
            180                 185                 190         


Asn Asn Tyr Asn Tyr Val Ile Arg Ala Lys Val Lys Glu Ile Lys Thr 
        195                 200                 205             


Lys Cys His Asp Val Thr Ala Val Val Glu Val Lys Glu Ile Leu Lys 
    210                 215                 220                 


Ser Ser Leu Val Asn Ile Pro Arg Asp Thr Val Asn Leu Tyr Thr Ser 
225                 230                 235                 240 


Ser Gly Cys Leu Cys Pro Pro Leu Asn Val Asn Glu Glu Tyr Ile Ile 
                245                 250                 255     


Met Gly Tyr Glu Asp Glu Glu Arg Ser Arg Leu Leu Leu Val Glu Gly 
            260                 265                 270         


Ser Ile Ala Glu Lys Trp Lys Asp Arg Leu Gly Lys Lys Val Lys Arg 
        275                 280                 285             


Trp Asp Met Lys Leu Arg His Leu Gly Leu Ser Lys Ser Asp Ser Ser 
    290                 295                 300                 


Asn Ser Asp Ser Thr Gln Ser Gln Lys Ser Gly Arg Asn Ser Asn Pro 
305                 310                 315                 320 


Arg Gln Ala Arg Asn 
                325 


<210>  5563
<211>  129
<212>  PRT
<213>  Homo Sapiens

<400>  5563

Met Lys Thr Leu Gln Phe Phe Phe Leu Phe Cys Cys Trp Lys Ala Ile 
1               5                   10                  15      


Cys Cys Asn Ser Cys Glu Leu Thr Asn Ile Thr Ile Ala Ile Glu Lys 
            20                  25                  30          


Glu Glu Cys Arg Phe Cys Ile Ser Ile Asn Thr Thr Trp Cys Ala Gly 
        35                  40                  45              


Tyr Cys Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys 
    50                  55                  60                  


Ile Gln Lys Thr Cys Thr Phe Lys Glu Leu Val Tyr Glu Thr Val Arg 
65                  70                  75                  80  


Val Pro Gly Cys Ala His His Ala Asp Ser Leu Tyr Thr Tyr Pro Val 
                85                  90                  95      


Ala Thr Gln Cys His Cys Gly Lys Cys Asp Ser Asp Ser Thr Asp Cys 
            100                 105                 110         


Thr Val Arg Gly Leu Gly Pro Ser Tyr Cys Ser Phe Gly Glu Met Lys 
        115                 120                 125             


Glu 
    


<210>  5564
<211>  129
<212>  PRT
<213>  Homo Sapiens

<400>  5564

Met Lys Thr Leu Gln Phe Phe Phe Leu Phe Cys Cys Trp Lys Ala Ile 
1               5                   10                  15      


Cys Cys Asn Ser Cys Glu Leu Thr Asn Ile Thr Ile Ala Ile Glu Lys 
            20                  25                  30          


Glu Glu Cys Arg Phe Cys Ile Ser Ile Asn Thr Thr Trp Cys Ala Gly 
        35                  40                  45              


Tyr Cys Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys 
    50                  55                  60                  


Ile Gln Lys Thr Cys Thr Phe Lys Glu Leu Val Tyr Glu Thr Val Arg 
65                  70                  75                  80  


Val Pro Gly Cys Ala His His Ala Asp Ser Leu Tyr Thr Tyr Pro Val 
                85                  90                  95      


Ala Thr Gln Cys His Cys Gly Lys Cys Asp Ser Asp Ser Thr Asp Cys 
            100                 105                 110         


Thr Val Arg Gly Leu Gly Pro Ser Tyr Cys Ser Phe Gly Glu Met Lys 
        115                 120                 125             


Glu 
    


<210>  5565
<211>  129
<212>  PRT
<213>  Homo Sapiens

<400>  5565

Met Lys Thr Leu Gln Phe Phe Phe Leu Phe Cys Cys Trp Lys Ala Ile 
1               5                   10                  15      


Cys Cys Asn Ser Cys Glu Leu Thr Asn Ile Thr Ile Ala Ile Glu Lys 
            20                  25                  30          


Glu Glu Cys Arg Phe Cys Ile Ser Ile Asn Thr Thr Trp Cys Ala Gly 
        35                  40                  45              


Tyr Cys Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys 
    50                  55                  60                  


Ile Gln Lys Thr Cys Thr Phe Lys Glu Leu Val Tyr Glu Thr Val Arg 
65                  70                  75                  80  


Val Pro Gly Cys Ala His His Ala Asp Ser Leu Tyr Thr Tyr Pro Val 
                85                  90                  95      


Ala Thr Gln Cys His Cys Gly Lys Cys Asp Ser Asp Ser Thr Asp Cys 
            100                 105                 110         


Thr Val Arg Gly Leu Gly Pro Ser Tyr Cys Ser Phe Gly Glu Met Lys 
        115                 120                 125             


Glu 
    


<210>  5566
<211>  695
<212>  PRT
<213>  Homo Sapiens

<400>  5566

Met Ala Leu Leu Leu Val Ser Leu Leu Ala Phe Leu Ser Leu Gly Ser 
1               5                   10                  15      


Gly Cys His His Arg Ile Cys His Cys Ser Asn Arg Val Phe Leu Cys 
            20                  25                  30          


Gln Glu Ser Lys Val Thr Glu Ile Pro Ser Asp Leu Pro Arg Asn Ala 
        35                  40                  45              


Ile Glu Leu Arg Phe Val Leu Thr Lys Leu Arg Val Ile Gln Lys Gly 
    50                  55                  60                  


Ala Phe Ser Gly Phe Gly Asp Leu Glu Lys Ile Glu Ile Ser Gln Asn 
65                  70                  75                  80  


Asp Val Leu Glu Val Ile Glu Ala Asp Val Phe Ser Asn Leu Pro Lys 
                85                  90                  95      


Leu His Glu Ile Arg Ile Glu Lys Ala Asn Asn Leu Leu Tyr Ile Asn 
            100                 105                 110         


Pro Glu Ala Phe Gln Asn Leu Pro Asn Leu Gln Tyr Leu Leu Ile Ser 
        115                 120                 125             


Asn Thr Gly Ile Lys His Leu Pro Asp Val His Lys Ile His Ser Leu 
    130                 135                 140                 


Gln Lys Val Leu Leu Asp Ile Gln Asp Asn Ile Asn Ile His Thr Ile 
145                 150                 155                 160 


Glu Arg Asn Ser Phe Val Gly Leu Ser Phe Glu Ser Val Ile Leu Trp 
                165                 170                 175     


Leu Asn Lys Asn Gly Ile Gln Glu Ile His Asn Cys Ala Phe Asn Gly 
            180                 185                 190         


Thr Gln Leu Asp Glu Leu Asn Leu Ser Asp Asn Asn Asn Leu Glu Glu 
        195                 200                 205             


Leu Pro Asn Asp Val Phe His Gly Ala Ser Gly Pro Val Ile Leu Asp 
    210                 215                 220                 


Ile Ser Arg Thr Arg Ile His Ser Leu Pro Ser Tyr Gly Leu Glu Asn 
225                 230                 235                 240 


Leu Lys Lys Leu Arg Ala Arg Ser Thr Tyr Asn Leu Lys Lys Leu Pro 
                245                 250                 255     


Thr Leu Glu Lys Leu Val Ala Leu Met Glu Ala Ser Leu Thr Tyr Pro 
            260                 265                 270         


Ser His Cys Cys Ala Phe Ala Asn Trp Arg Arg Gln Ile Ser Glu Leu 
        275                 280                 285             


His Pro Ile Cys Asn Lys Ser Ile Leu Arg Gln Glu Val Asp Tyr Met 
    290                 295                 300                 


Thr Gln Ala Arg Gly Gln Arg Ser Ser Leu Ala Glu Asp Asn Glu Ser 
305                 310                 315                 320 


Ser Tyr Ser Arg Gly Phe Asp Met Thr Tyr Thr Glu Phe Asp Tyr Asp 
                325                 330                 335     


Leu Cys Asn Glu Val Val Asp Val Thr Cys Ser Pro Lys Pro Asp Ala 
            340                 345                 350         


Phe Asn Pro Cys Glu Asp Ile Met Gly Tyr Asn Ile Leu Arg Val Leu 
        355                 360                 365             


Ile Trp Phe Ile Ser Ile Leu Ala Ile Thr Gly Asn Ile Ile Val Leu 
    370                 375                 380                 


Val Ile Leu Thr Thr Ser Gln Tyr Lys Leu Thr Val Pro Arg Phe Leu 
385                 390                 395                 400 


Met Cys Asn Leu Ala Phe Ala Asp Leu Cys Ile Gly Ile Tyr Leu Leu 
                405                 410                 415     


Leu Ile Ala Ser Val Asp Ile His Thr Lys Ser Gln Tyr His Asn Tyr 
            420                 425                 430         


Ala Ile Asp Trp Gln Thr Gly Ala Gly Cys Asp Ala Ala Gly Phe Phe 
        435                 440                 445             


Thr Val Phe Ala Ser Glu Leu Ser Val Tyr Thr Leu Thr Ala Ile Thr 
    450                 455                 460                 


Leu Glu Arg Trp His Thr Ile Thr His Ala Met Gln Leu Asp Cys Lys 
465                 470                 475                 480 


Val Gln Leu Arg His Ala Ala Ser Val Met Val Met Gly Trp Ile Phe 
                485                 490                 495     


Ala Phe Ala Ala Ala Leu Phe Pro Ile Phe Gly Ile Ser Ser Tyr Met 
            500                 505                 510         


Lys Val Ser Ile Cys Leu Pro Met Asp Ile Asp Ser Pro Leu Ser Gln 
        515                 520                 525             


Leu Tyr Val Met Ser Leu Leu Val Leu Asn Val Leu Ala Phe Val Val 
    530                 535                 540                 


Ile Cys Gly Cys Tyr Ile His Ile Tyr Leu Thr Val Arg Asn Pro Asn 
545                 550                 555                 560 


Ile Val Ser Ser Ser Ser Asp Thr Arg Ile Ala Lys Arg Met Ala Met 
                565                 570                 575     


Leu Ile Phe Thr Asp Phe Leu Cys Met Ala Pro Ile Ser Phe Phe Ala 
            580                 585                 590         


Ile Ser Ala Ser Leu Lys Val Pro Leu Ile Thr Val Ser Lys Ala Lys 
        595                 600                 605             


Ile Leu Leu Val Leu Phe His Pro Ile Asn Ser Cys Ala Asn Pro Phe 
    610                 615                 620                 


Leu Tyr Ala Ile Phe Thr Lys Asn Phe Arg Arg Asp Phe Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Lys Cys Gly Cys Tyr Glu Met Gln Ala Gln Ile Tyr Arg Thr 
                645                 650                 655     


Glu Thr Ser Ser Thr Val His Asn Thr His Pro Arg Asn Gly His Cys 
            660                 665                 670         


Ser Ser Ala Pro Arg Val Thr Ser Gly Ser Thr Tyr Ile Leu Val Pro 
        675                 680                 685             


Leu Ser His Leu Ala Gln Asn 
    690                 695 


<210>  5567
<211>  278
<212>  PRT
<213>  Homo Sapiens

<400>  5567

Met Ala Leu Leu Leu Val Ser Leu Leu Ala Phe Leu Ser Leu Gly Ser 
1               5                   10                  15      


Gly Cys His His Arg Ile Cys His Cys Ser Asn Arg Val Phe Leu Cys 
            20                  25                  30          


Gln Glu Ser Lys Val Thr Glu Ile Pro Ser Asp Leu Pro Arg Asn Ala 
        35                  40                  45              


Ile Glu Leu Arg Phe Val Leu Thr Lys Leu Arg Val Ile Gln Lys Gly 
    50                  55                  60                  


Ala Phe Ser Gly Phe Gly Asp Leu Glu Lys Ile Glu Ile Ser Gln Asn 
65                  70                  75                  80  


Asp Val Leu Glu Val Ile Glu Ala Asp Val Phe Ser Asn Leu Pro Lys 
                85                  90                  95      


Leu His Glu Ile Arg Ile Glu Lys Ala Asn Asn Leu Leu Tyr Ile Asn 
            100                 105                 110         


Pro Glu Ala Phe Gln Asn Leu Pro Asn Leu Gln Tyr Leu Leu Ile Ser 
        115                 120                 125             


Asn Thr Gly Ile Lys His Leu Pro Asp Val His Lys Ile His Ser Leu 
    130                 135                 140                 


Gln Lys Val Leu Leu Asp Ile Gln Asp Asn Ile Asn Ile His Thr Ile 
145                 150                 155                 160 


Glu Arg Asn Ser Phe Val Gly Leu Ser Phe Glu Ser Val Ile Leu Trp 
                165                 170                 175     


Leu Asn Lys Asn Gly Ile Gln Glu Ile His Asn Cys Ala Phe Asn Gly 
            180                 185                 190         


Thr Gln Leu Asp Glu Leu Asn Leu Ser Asp Asn Asn Asn Leu Glu Glu 
        195                 200                 205             


Leu Pro Asn Asp Val Phe His Gly Ala Ser Gly Pro Val Ile Leu Ser 
    210                 215                 220                 


Glu Leu His Pro Ile Cys Asn Lys Ser Ile Leu Arg Gln Glu Val Asp 
225                 230                 235                 240 


Tyr Met Thr Gln Ala Arg Gly Gln Arg Ser Ser Leu Ala Glu Asp Asn 
                245                 250                 255     


Glu Ser Ser Tyr Ser Arg Gly Phe Asp Met Thr Tyr Thr Glu Phe Asp 
            260                 265                 270         


Tyr Asp Leu Cys Asn Glu 
        275             


<210>  5568
<211>  669
<212>  PRT
<213>  Homo Sapiens

<400>  5568

Met Ala Leu Leu Leu Val Ser Leu Leu Ala Phe Leu Ser Leu Gly Ser 
1               5                   10                  15      


Gly Cys His His Arg Ile Cys His Cys Ser Asn Arg Val Phe Leu Cys 
            20                  25                  30          


Gln Glu Ser Lys Val Thr Glu Ile Pro Ser Asp Leu Pro Arg Asn Ala 
        35                  40                  45              


Ile Glu Leu Arg Phe Val Leu Thr Lys Leu Arg Val Ile Gln Lys Gly 
    50                  55                  60                  


Ala Phe Ser Gly Phe Gly Asp Leu Glu Lys Ile Glu Ile Ser Gln Asn 
65                  70                  75                  80  


Asp Val Leu Glu Val Ile Glu Ala Asp Val Phe Ser Asn Leu Pro Lys 
                85                  90                  95      


Leu His Glu Ile Arg Ile Glu Lys Ala Asn Asn Leu Leu Tyr Ile Asn 
            100                 105                 110         


Pro Glu Ala Phe Gln Asn Leu Pro Asn Leu Gln Tyr Leu Leu Ile Ser 
        115                 120                 125             


Asn Thr Gly Ile Lys His Leu Pro Asp Val His Lys Ile His Ser Leu 
    130                 135                 140                 


Gln Lys Val Leu Leu Trp Leu Asn Lys Asn Gly Ile Gln Glu Ile His 
145                 150                 155                 160 


Asn Cys Ala Phe Asn Gly Thr Gln Leu Asp Glu Leu Asn Leu Ser Asp 
                165                 170                 175     


Asn Asn Asn Leu Glu Glu Leu Pro Asn Asp Val Phe His Gly Ala Ser 
            180                 185                 190         


Gly Pro Val Ile Leu Asp Ile Ser Arg Thr Arg Ile His Ser Leu Pro 
        195                 200                 205             


Ser Tyr Gly Leu Glu Asn Leu Lys Lys Leu Arg Ala Arg Ser Thr Tyr 
    210                 215                 220                 


Asn Leu Lys Lys Leu Pro Thr Leu Glu Lys Leu Val Ala Leu Met Glu 
225                 230                 235                 240 


Ala Ser Leu Thr Tyr Pro Ser His Cys Cys Ala Phe Ala Asn Trp Arg 
                245                 250                 255     


Arg Gln Ile Ser Glu Leu His Pro Ile Cys Asn Lys Ser Ile Leu Arg 
            260                 265                 270         


Gln Glu Val Asp Tyr Met Thr Gln Ala Arg Gly Gln Arg Ser Ser Leu 
        275                 280                 285             


Ala Glu Asp Asn Glu Ser Ser Tyr Ser Arg Gly Phe Asp Met Thr Tyr 
    290                 295                 300                 


Thr Glu Phe Asp Tyr Asp Leu Cys Asn Glu Val Val Asp Val Thr Cys 
305                 310                 315                 320 


Ser Pro Lys Pro Asp Ala Phe Asn Pro Cys Glu Asp Ile Met Gly Tyr 
                325                 330                 335     


Asn Ile Leu Arg Val Leu Ile Trp Phe Ile Ser Ile Leu Ala Ile Thr 
            340                 345                 350         


Gly Asn Ile Ile Val Leu Val Ile Leu Thr Thr Ser Gln Tyr Lys Leu 
        355                 360                 365             


Thr Val Pro Arg Phe Leu Met Cys Asn Leu Ala Phe Ala Asp Leu Cys 
    370                 375                 380                 


Ile Gly Ile Tyr Leu Leu Leu Ile Ala Ser Val Asp Ile His Thr Lys 
385                 390                 395                 400 


Ser Gln Tyr His Asn Tyr Ala Ile Asp Trp Gln Thr Gly Ala Gly Cys 
                405                 410                 415     


Asp Ala Ala Gly Phe Phe Thr Val Phe Ala Ser Glu Leu Ser Val Tyr 
            420                 425                 430         


Thr Leu Thr Ala Ile Thr Leu Glu Arg Trp His Thr Ile Thr His Ala 
        435                 440                 445             


Met Gln Leu Asp Cys Lys Val Gln Leu Arg His Ala Ala Ser Val Met 
    450                 455                 460                 


Val Met Gly Trp Ile Phe Ala Phe Ala Ala Ala Leu Phe Pro Ile Phe 
465                 470                 475                 480 


Gly Ile Ser Ser Tyr Met Lys Val Ser Ile Cys Leu Pro Met Asp Ile 
                485                 490                 495     


Asp Ser Pro Leu Ser Gln Leu Tyr Val Met Ser Leu Leu Val Leu Asn 
            500                 505                 510         


Val Leu Ala Phe Val Val Ile Cys Gly Cys Tyr Ile His Ile Tyr Leu 
        515                 520                 525             


Thr Val Arg Asn Pro Asn Ile Val Ser Ser Ser Ser Asp Thr Arg Ile 
    530                 535                 540                 


Ala Lys Arg Met Ala Met Leu Ile Phe Thr Asp Phe Leu Cys Met Ala 
545                 550                 555                 560 


Pro Ile Ser Phe Phe Ala Ile Ser Ala Ser Leu Lys Val Pro Leu Ile 
                565                 570                 575     


Thr Val Ser Lys Ala Lys Ile Leu Leu Val Leu Phe His Pro Ile Asn 
            580                 585                 590         


Ser Cys Ala Asn Pro Phe Leu Tyr Ala Ile Phe Thr Lys Asn Phe Arg 
        595                 600                 605             


Arg Asp Phe Phe Ile Leu Leu Ser Lys Cys Gly Cys Tyr Glu Met Gln 
    610                 615                 620                 


Ala Gln Ile Tyr Arg Thr Glu Thr Ser Ser Thr Val His Asn Thr His 
625                 630                 635                 640 


Pro Arg Asn Gly His Cys Ser Ser Ala Pro Arg Val Thr Ser Gly Ser 
                645                 650                 655     


Thr Tyr Ile Leu Val Pro Leu Ser His Leu Ala Gln Asn 
            660                 665                 


<210>  5569
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  5569

Met Ala Leu Leu Leu Val Ser Leu Leu Ala Phe Leu Ser Leu Gly Ser 
1               5                   10                  15      


Gly Cys His His Arg Ile Cys His Cys Ser Asn Arg Val Phe Leu Cys 
            20                  25                  30          


Gln Glu Ser Lys Val Thr Glu Ile Pro Ser Asp Leu Pro Arg Asn Ala 
        35                  40                  45              


Ile Glu Leu Arg Phe Val Leu Thr Lys Leu Arg Val Ile Gln Lys Gly 
    50                  55                  60                  


Ala Phe Ser Gly Phe Gly Asp Leu Glu Lys Ile Glu Ile Ser Gln Asn 
65                  70                  75                  80  


Asp Val Leu Glu Val Ile Glu Ala Asp Val Phe Ser Asn Leu Pro Lys 
                85                  90                  95      


Leu His Glu Ile Arg Ile Glu Lys Ala Asn Asn Leu Leu Tyr Ile Asn 
            100                 105                 110         


Pro Glu Ala Phe Gln Asn Leu Pro Asn Leu Gln Tyr Leu Ser Phe Ser 
        115                 120                 125             


Ser Phe Val Leu Glu Asn Ala Lys Val Glu Asn Gly Asp His Arg Ala 
    130                 135                 140                 


Phe Ser Asp Arg Thr Asn Ala Leu 
145                 150         


<210>  5570
<211>  215
<212>  PRT
<213>  Homo Sapiens

<400>  5570

Gly Pro Val Cys Gly Leu Asp Gly Lys Thr Tyr Arg Asn Glu Cys Ala 
1               5                   10                  15      


Leu Leu Lys Ala Arg Cys Lys Glu Gln Pro Glu Leu Glu Val Gln Tyr 
            20                  25                  30          


Gln Gly Arg Cys Lys Lys Thr Cys Arg Asp Val Phe Cys Pro Gly Ser 
        35                  40                  45              


Ser Thr Cys Val Val Asp Gln Thr Asn Asn Ala Tyr Cys Val Thr Cys 
    50                  55                  60                  


Asn Arg Ile Cys Pro Glu Pro Ala Ser Ser Glu Gln Tyr Leu Cys Gly 
65                  70                  75                  80  


Asn Asp Gly Val Thr Tyr Ser Ser Ala Cys His Leu Arg Lys Ala Thr 
                85                  90                  95      


Cys Leu Leu Gly Arg Ser Ile Gly Leu Ala Tyr Glu Gly Lys Cys Ile 
            100                 105                 110         


Thr Lys Ser Cys Glu Asp Ile Gln Cys Thr Gly Gly Lys Lys Cys Leu 
        115                 120                 125             


Trp Asp Phe Lys Val Gly Arg Gly Arg Cys Ser Leu Cys Asp Glu Leu 
    130                 135                 140                 


Cys Pro Asp Ser Lys Ser Asp Glu Pro Val Cys Ala Ser Asp Asn Ala 
145                 150                 155                 160 


Thr Tyr Ala Ser Glu Cys Ala Met Lys Glu Ala Ala Cys Ser Ser Gly 
                165                 170                 175     


Val Leu Leu Glu Val Lys His Ser Gly Ser Cys Asn Ser Ile Ser Glu 
            180                 185                 190         


Asp Thr Glu Glu Glu Glu Glu Asp Glu Asp Gln Asp Tyr Ser Phe Pro 
        195                 200                 205             


Ile Ser Ser Ile Leu Glu Trp 
    210                 215 


<210>  5571
<211>  344
<212>  PRT
<213>  Homo Sapiens

<400>  5571

Met Val Arg Ala Arg His Gln Pro Gly Gly Leu Cys Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Cys Gln Phe Met Glu Asp Arg Ser Ala Gln Ala Gly Asn Cys 
            20                  25                  30          


Trp Leu Arg Gln Ala Lys Asn Gly Arg Cys Gln Val Leu Tyr Lys Thr 
        35                  40                  45              


Glu Leu Ser Lys Glu Glu Cys Cys Ser Thr Gly Arg Leu Ser Thr Ser 
    50                  55                  60                  


Trp Thr Glu Glu Asp Val Asn Asp Asn Thr Leu Phe Lys Trp Met Ile 
65                  70                  75                  80  


Phe Asn Gly Gly Ala Pro Asn Cys Ile Pro Cys Lys Glu Thr Cys Glu 
                85                  90                  95      


Asn Val Asp Cys Gly Pro Gly Lys Lys Cys Arg Met Asn Lys Lys Asn 
            100                 105                 110         


Lys Pro Arg Cys Val Cys Ala Pro Asp Cys Ser Asn Ile Thr Trp Lys 
        115                 120                 125             


Gly Pro Val Cys Gly Leu Asp Gly Lys Thr Tyr Arg Asn Glu Cys Ala 
    130                 135                 140                 


Leu Leu Lys Ala Arg Cys Lys Glu Gln Pro Glu Leu Glu Val Gln Tyr 
145                 150                 155                 160 


Gln Gly Arg Cys Lys Lys Thr Cys Arg Asp Val Phe Cys Pro Gly Ser 
                165                 170                 175     


Ser Thr Cys Val Val Asp Gln Thr Asn Asn Ala Tyr Cys Val Thr Cys 
            180                 185                 190         


Asn Arg Ile Cys Pro Glu Pro Ala Ser Ser Glu Gln Tyr Leu Cys Gly 
        195                 200                 205             


Asn Asp Gly Val Thr Tyr Ser Ser Ala Cys His Leu Arg Lys Ala Thr 
    210                 215                 220                 


Cys Leu Leu Gly Arg Ser Ile Gly Leu Ala Tyr Glu Gly Lys Cys Ile 
225                 230                 235                 240 


Lys Ala Lys Ser Cys Glu Asp Ile Gln Cys Thr Gly Gly Lys Lys Cys 
                245                 250                 255     


Leu Trp Asp Phe Lys Val Gly Arg Gly Arg Cys Ser Leu Cys Asp Glu 
            260                 265                 270         


Leu Cys Pro Asp Ser Lys Ser Asp Glu Pro Val Cys Ala Ser Asp Asn 
        275                 280                 285             


Ala Thr Tyr Ala Ser Glu Cys Ala Met Lys Glu Ala Ala Cys Ser Ser 
    290                 295                 300                 


Gly Val Leu Leu Glu Val Lys His Ser Gly Ser Cys Asn Ser Ile Ser 
305                 310                 315                 320 


Glu Asp Thr Glu Glu Glu Glu Glu Asp Glu Asp Gln Asp Tyr Ser Phe 
                325                 330                 335     


Pro Ile Ser Ser Ile Leu Glu Trp 
            340                 


<210>  5572
<211>  317
<212>  PRT
<213>  Homo Sapiens

<400>  5572

Met Val Arg Ala Arg His Gln Pro Gly Gly Leu Cys Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Cys Gln Phe Met Glu Asp Arg Ser Ala Gln Ala Gly Asn Cys 
            20                  25                  30          


Trp Leu Arg Gln Ala Lys Asn Gly Arg Cys Gln Val Leu Tyr Lys Thr 
        35                  40                  45              


Glu Leu Ser Lys Glu Glu Cys Cys Ser Thr Gly Arg Leu Ser Thr Ser 
    50                  55                  60                  


Trp Thr Glu Glu Asp Val Asn Asp Asn Thr Leu Phe Lys Trp Met Ile 
65                  70                  75                  80  


Phe Asn Gly Gly Ala Pro Asn Cys Ile Pro Cys Lys Glu Thr Cys Glu 
                85                  90                  95      


Asn Val Asp Cys Gly Pro Gly Lys Lys Cys Arg Met Asn Lys Lys Asn 
            100                 105                 110         


Lys Pro Arg Cys Val Cys Ala Pro Asp Cys Ser Asn Ile Thr Trp Lys 
        115                 120                 125             


Gly Pro Val Cys Gly Leu Asp Gly Lys Thr Tyr Arg Asn Glu Cys Ala 
    130                 135                 140                 


Leu Leu Lys Ala Arg Cys Lys Glu Gln Pro Glu Leu Glu Val Gln Tyr 
145                 150                 155                 160 


Gln Gly Arg Cys Lys Lys Thr Cys Arg Asp Val Phe Cys Pro Gly Ser 
                165                 170                 175     


Ser Thr Cys Val Val Asp Gln Thr Asn Asn Ala Tyr Cys Val Thr Cys 
            180                 185                 190         


Asn Arg Ile Cys Pro Glu Pro Ala Ser Ser Glu Gln Tyr Leu Cys Gly 
        195                 200                 205             


Asn Asp Gly Val Thr Tyr Ser Ser Ala Cys His Leu Arg Lys Ala Thr 
    210                 215                 220                 


Cys Leu Leu Gly Arg Ser Ile Gly Leu Ala Tyr Glu Gly Lys Cys Ile 
225                 230                 235                 240 


Lys Ala Lys Ser Cys Glu Asp Ile Gln Cys Thr Gly Gly Lys Lys Cys 
                245                 250                 255     


Leu Trp Asp Phe Lys Val Gly Arg Gly Arg Cys Ser Leu Cys Asp Glu 
            260                 265                 270         


Leu Cys Pro Asp Ser Lys Ser Asp Glu Pro Val Cys Ala Ser Asp Asn 
        275                 280                 285             


Ala Thr Tyr Ala Ser Glu Cys Ala Met Lys Glu Ala Ala Cys Ser Ser 
    290                 295                 300                 


Gly Val Leu Leu Glu Val Lys His Ser Gly Ser Cys Asn 
305                 310                 315         


<210>  5573
<211>  102
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5573

Xaa Ser Ala Cys His Leu Arg Lys Ala Thr Cys Leu Leu Gly Arg Ser 
1               5                   10                  15      


Ile Gly Leu Ala Tyr Glu Gly Lys Cys Ile Thr Lys Ser Cys Glu Asp 
            20                  25                  30          


Ile Gln Cys Thr Gly Gly Lys Lys Cys Leu Trp Asp Phe Lys Val Gly 
        35                  40                  45              


Arg Gly Arg Cys Ser Leu Cys Asp Glu Leu Cys Pro Asp Ser Lys Ser 
    50                  55                  60                  


Asp Glu Pro Val Cys Ala Ser Asp Asn Ala Thr Tyr Ala Ser Glu Cys 
65                  70                  75                  80  


Ala Met Lys Glu Ala Ala Cys Ser Ser Gly Val Leu Leu Glu Val Lys 
                85                  90                  95      


His Ser Gly Ser Cys Asn 
            100         


<210>  5574
<211>  140
<212>  PRT
<213>  Homo Sapiens

<400>  5574

Met Trp Lys Arg Trp Leu Ala Leu Ala Leu Ala Leu Val Ala Val Ala 
1               5                   10                  15      


Trp Val Arg Ala Glu Glu Glu Leu Arg Ser Lys Ser Lys Ile Cys Ala 
            20                  25                  30          


Asn Val Phe Cys Gly Ala Gly Arg Glu Cys Ala Val Thr Glu Lys Gly 
        35                  40                  45              


Glu Pro Thr Cys Leu Cys Ile Glu Gln Cys Lys Pro His Lys Arg Pro 
    50                  55                  60                  


Val Cys Gly Ser Asn Gly Lys Thr Tyr Leu Asn His Cys Glu Leu His 
65                  70                  75                  80  


Arg Asp Ala Cys Leu Thr Gly Ser Lys Ile Gln Val Asp Tyr Asp Gly 
                85                  90                  95      


His Cys Lys Glu Lys Lys Ser Val Ser Pro Ser Ala Ser Pro Val Val 
            100                 105                 110         


Cys Tyr Gln Ser Asn Arg Asp Glu Leu Arg Arg Arg Ile Ile Gln Trp 
        115                 120                 125             


Leu Glu Ala Glu Ile Ile Pro Asp Gly Trp Phe Ser 
    130                 135                 140 


<210>  5575
<211>  308
<212>  PRT
<213>  Homo Sapiens

<400>  5575

Met Trp Lys Arg Trp Leu Ala Leu Ala Leu Ala Leu Val Ala Val Ala 
1               5                   10                  15      


Trp Val Arg Ala Glu Glu Glu Leu Arg Ser Lys Ser Lys Ile Cys Ala 
            20                  25                  30          


Asn Val Phe Cys Gly Ala Gly Arg Glu Cys Ala Val Thr Glu Lys Gly 
        35                  40                  45              


Glu Pro Thr Cys Leu Cys Ile Glu Gln Cys Lys Pro His Lys Arg Pro 
    50                  55                  60                  


Val Cys Gly Ser Asn Gly Lys Thr Tyr Leu Asn His Cys Glu Leu His 
65                  70                  75                  80  


Arg Asp Ala Cys Leu Thr Gly Ser Lys Ile Gln Val Asp Tyr Asp Gly 
                85                  90                  95      


His Cys Lys Glu Lys Lys Ser Val Ser Pro Ser Ala Ser Pro Val Val 
            100                 105                 110         


Cys Tyr Gln Ser Asn Arg Asp Glu Leu Arg Arg Arg Ile Ile Gln Trp 
        115                 120                 125             


Leu Glu Ala Glu Ile Ile Pro Asp Gly Trp Phe Ser Lys Gly Ser Asn 
    130                 135                 140                 


Tyr Ser Glu Ile Leu Asp Lys Tyr Phe Lys Asn Phe Asp Asn Gly Asp 
145                 150                 155                 160 


Ser Arg Leu Asp Ser Ser Glu Phe Leu Lys Phe Val Glu Gln Asn Glu 
                165                 170                 175     


Thr Ala Ile Asn Ile Thr Thr Tyr Pro Asp Gln Glu Asn Asn Lys Leu 
            180                 185                 190         


Leu Arg Gly Leu Cys Val Asp Ala Leu Ile Glu Leu Ser Asp Glu Asn 
        195                 200                 205             


Ala Asp Trp Lys Leu Ser Phe Gln Glu Phe Leu Lys Cys Leu Asn Pro 
    210                 215                 220                 


Ser Phe Asn Pro Pro Glu Lys Lys Cys Ala Leu Glu Asp Glu Thr Tyr 
225                 230                 235                 240 


Ala Asp Gly Ala Glu Thr Glu Val Asp Cys Asn Arg Cys Val Cys Ala 
                245                 250                 255     


Cys Gly Asn Trp Val Cys Thr Ala Met Thr Cys Asp Gly Lys Asn Gln 
            260                 265                 270         


Lys Gly Ala Gln Thr Gln Thr Glu Glu Glu Met Thr Arg Tyr Val Gln 
        275                 280                 285             


Glu Leu Gln Lys His Gln Glu Thr Ala Glu Lys Thr Lys Arg Val Ser 
    290                 295                 300                 


Thr Lys Glu Ile 
305             


<210>  5576
<211>  273
<212>  PRT
<213>  Homo Sapiens

<400>  5576

Met Trp Lys Arg Trp Leu Ala Leu Ala Leu Ala Leu Val Ala Val Ala 
1               5                   10                  15      


Trp Val Arg Ala Glu Gln Cys Lys Pro His Lys Arg Pro Val Cys Gly 
            20                  25                  30          


Ser Asn Gly Lys Thr Tyr Leu Asn His Cys Glu Leu His Arg Asp Ala 
        35                  40                  45              


Cys Leu Thr Gly Ser Lys Ile Gln Val Asp Tyr Asp Gly His Cys Lys 
    50                  55                  60                  


Glu Lys Lys Ser Val Ser Pro Ser Ala Ser Pro Val Val Cys Tyr Gln 
65                  70                  75                  80  


Ser Asn Arg Asp Glu Leu Arg Arg Arg Ile Ile Gln Trp Leu Glu Ala 
                85                  90                  95      


Glu Ile Ile Pro Asp Gly Trp Phe Ser Lys Gly Ser Asn Tyr Ser Glu 
            100                 105                 110         


Ile Leu Asp Lys Tyr Phe Lys Asn Phe Asp Asn Gly Asp Ser Arg Leu 
        115                 120                 125             


Asp Ser Ser Glu Phe Leu Lys Phe Val Glu Gln Asn Glu Thr Ala Ile 
    130                 135                 140                 


Asn Ile Thr Thr Tyr Pro Asp Gln Glu Asn Asn Lys Leu Leu Arg Gly 
145                 150                 155                 160 


Leu Cys Val Asp Ala Leu Ile Glu Leu Ser Asp Glu Asn Ala Asp Trp 
                165                 170                 175     


Lys Leu Ser Phe Gln Glu Phe Leu Lys Cys Leu Asn Pro Ser Phe Asn 
            180                 185                 190         


Pro Pro Glu Lys Lys Cys Ala Leu Glu Asp Glu Thr Tyr Ala Asp Gly 
        195                 200                 205             


Ala Glu Thr Glu Val Asp Cys Asn Arg Cys Val Cys Ala Cys Gly Asn 
    210                 215                 220                 


Trp Val Cys Thr Ala Met Thr Cys Asp Gly Lys Asn Gln Lys Gly Ala 
225                 230                 235                 240 


Gln Thr Gln Thr Glu Glu Glu Met Thr Arg Tyr Val Gln Glu Leu Gln 
                245                 250                 255     


Lys His Gln Glu Thr Ala Glu Lys Thr Lys Arg Val Ser Thr Lys Glu 
            260                 265                 270         


Ile 
    


<210>  5577
<211>  20
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5577

Xaa Ser Phe Gln Glu Phe Leu Lys Cys Leu Asn Pro Ser Phe Asn Pro 
1               5                   10                  15      


Pro Glu Lys Lys 
            20  


<210>  5578
<211>  84
<212>  PRT
<213>  Homo Sapiens

<400>  5578

Met Leu Gly Gly Arg Pro Arg Cys Glu Cys Ala Pro Asp Cys Ser Gly 
1               5                   10                  15      


Leu Pro Ala Arg Leu Gln Val Cys Gly Ser Asp Gly Ala Thr Tyr Arg 
            20                  25                  30          


Asp Glu Cys Glu Leu Arg Ala Ala Arg Cys Arg Gly His Pro Asp Leu 
        35                  40                  45              


Ser Val Met Tyr Arg Gly Arg Cys Arg Lys Ser Cys Glu His Val Val 
    50                  55                  60                  


Cys Pro Arg Pro Gln Ser Cys Val Val Asp Gln Thr Gly Ser Ala His 
65                  70                  75                  80  


Cys Val Val Cys 
                


<210>  5579
<211>  263
<212>  PRT
<213>  Homo Sapiens

<400>  5579

Met Arg Pro Gly Ala Pro Gly Pro Leu Trp Pro Leu Pro Trp Gly Ala 
1               5                   10                  15      


Leu Ala Trp Ala Val Gly Phe Val Ser Ser Met Gly Ser Gly Asn Pro 
            20                  25                  30          


Ala Pro Gly Gly Val Cys Trp Leu Gln Gln Gly Gln Glu Ala Thr Cys 
        35                  40                  45              


Ser Leu Val Leu Gln Thr Asp Val Thr Arg Ala Glu Cys Cys Ala Ser 
    50                  55                  60                  


Gly Asn Ile Asp Thr Ala Trp Ser Asn Leu Thr His Pro Gly Asn Lys 
65                  70                  75                  80  


Ile Asn Leu Leu Gly Phe Leu Gly Leu Val His Cys Leu Pro Cys Lys 
                85                  90                  95      


Asp Ser Cys Asp Gly Val Glu Cys Gly Pro Gly Lys Ala Cys Arg Met 
            100                 105                 110         


Leu Gly Gly Arg Pro Arg Cys Glu Cys Ala Pro Asp Cys Ser Gly Leu 
        115                 120                 125             


Pro Ala Arg Leu Gln Val Cys Gly Ser Asp Gly Ala Thr Tyr Arg Asp 
    130                 135                 140                 


Glu Cys Glu Leu Arg Ala Ala Arg Cys Arg Gly His Pro Asp Leu Ser 
145                 150                 155                 160 


Val Met Tyr Arg Gly Arg Cys Arg Lys Ser Cys Glu His Val Val Cys 
                165                 170                 175     


Pro Arg Pro Gln Ser Cys Val Val Asp Gln Thr Gly Ser Ala His Cys 
            180                 185                 190         


Val Val Cys Arg Ala Ala Pro Cys Pro Val Pro Ser Ser Pro Gly Gln 
        195                 200                 205             


Glu Leu Cys Gly Asn Asn Asn Val Thr Tyr Ile Ser Ser Cys His Met 
    210                 215                 220                 


Arg Gln Ala Thr Cys Phe Leu Gly Arg Ser Ile Gly Val Arg His Ala 
225                 230                 235                 240 


Gly Ser Cys Ala Gly Thr Pro Glu Glu Pro Pro Gly Gly Glu Ser Ala 
                245                 250                 255     


Glu Glu Glu Glu Asn Phe Val 
            260             


<210>  5580
<211>  92
<212>  PRT
<213>  Homo Sapiens

<400>  5580

Met Arg Gln Ala Thr Cys Phe Leu Gly Arg Ser Ile Gly Val Arg His 
1               5                   10                  15      


Ala Gly Ser Cys Ala Gly Ala Asp Ala Gly Arg Gly His Arg Pro Val 
            20                  25                  30          


Leu Gly Ala Gly Glu Pro Pro Ala Leu Arg Pro Gln Cys Ser Tyr Arg 
        35                  40                  45              


Pro Leu Gln Ala Pro Leu Arg Ser Arg Gln Val Val Ser Leu Gln Lys 
    50                  55                  60                  


Arg Lys Arg Thr Ser Cys Glu Pro Ala Gly Gln Ala Trp Ala Trp Cys 
65                  70                  75                  80  


Pro Arg Pro Pro Ile Ile Pro Cys Tyr Leu Leu Pro 
                85                  90          


<210>  5581
<211>  40
<212>  PRT
<213>  Homo Sapiens

<400>  5581

Met Arg Gln Ala Thr Cys Phe Leu Gly Arg Ser Ile Gly Val Arg His 
1               5                   10                  15      


Ala Gly Ser Cys Ala Gly Thr Pro Glu Glu Pro Pro Gly Gly Glu Ser 
            20                  25                  30          


Ala Glu Glu Glu Glu Asn Phe Val 
        35                  40  


<210>  5582
<211>  40
<212>  PRT
<213>  Homo Sapiens

<400>  5582

Met Arg Gln Ala Thr Cys Phe Leu Gly Arg Ser Ile Gly Val Arg His 
1               5                   10                  15      


Ala Gly Ser Cys Ala Gly Thr Pro Glu Glu Pro Pro Gly Gly Glu Ser 
            20                  25                  30          


Ala Glu Glu Glu Glu Asn Phe Val 
        35                  40  


<210>  5583
<211>  40
<212>  PRT
<213>  Homo Sapiens

<400>  5583

Met Arg Gln Ala Thr Cys Phe Leu Gly Arg Ser Ile Gly Val Arg His 
1               5                   10                  15      


Ala Gly Ser Cys Ala Gly Thr Pro Glu Glu Pro Pro Gly Gly Glu Ser 
            20                  25                  30          


Ala Glu Glu Glu Glu Asn Phe Val 
        35                  40  


<210>  5584
<211>  673
<212>  PRT
<213>  Homo Sapiens

<400>  5584

Met Lys Pro Gly Gly Phe Trp Leu His Leu Thr Leu Leu Gly Ala Ser 
1               5                   10                  15      


Leu Pro Ala Ala Leu Gly Trp Met Asp Pro Gly Thr Ser Arg Gly Pro 
            20                  25                  30          


Asp Val Gly Val Gly Glu Ser Gln Ala Glu Glu Pro Arg Ser Phe Glu 
        35                  40                  45              


Val Thr Arg Arg Glu Gly Leu Ser Ser His Asn Glu Leu Leu Ala Ser 
    50                  55                  60                  


Cys Gly Lys Lys Phe Cys Ser Arg Gly Ser Arg Cys Val Leu Ser Leu 
65                  70                  75                  80  


Ala Pro Glu Asp Arg Val Ser Val Thr Thr Val Thr Val Gly Leu Ser 
                85                  90                  95      


Thr Val Leu Thr Cys Ala Val His Gly Asp Leu Arg Pro Pro Ile Ile 
            100                 105                 110         


Trp Lys Arg Asn Gly Leu Thr Leu Asn Phe Leu Asp Leu Glu Asp Ile 
        115                 120                 125             


Asn Asp Phe Gly Glu Asp Asp Ser Leu Tyr Ile Thr Lys Val Thr Thr 
    130                 135                 140                 


Ile His Met Gly Asn Tyr Thr Cys His Ala Ser Gly His Glu Gln Leu 
145                 150                 155                 160 


Phe Gln Thr His Val Leu Gln Val Asn Val Pro Pro Val Ile Arg Val 
                165                 170                 175     


Tyr Pro Glu Ser Gln Ala Gln Glu Pro Gly Val Ala Ala Ser Leu Arg 
            180                 185                 190         


Cys His Ala Glu Gly Ile Pro Met Pro Arg Ile Thr Trp Leu Lys Asn 
        195                 200                 205             


Gly Val Asp Val Ser Thr Gln Met Ser Lys Gln Leu Ser Leu Leu Ala 
    210                 215                 220                 


Asn Gly Ser Glu Leu His Ile Ser Ser Val Arg Tyr Glu Asp Thr Gly 
225                 230                 235                 240 


Ala Tyr Thr Cys Ile Ala Lys Asn Glu Val Gly Val Asp Glu Asp Ile 
                245                 250                 255     


Ser Ser Leu Phe Ile Glu Asp Ser Ala Arg Lys Thr Leu Ala Asn Ile 
            260                 265                 270         


Leu Trp Arg Glu Glu Gly Leu Ser Val Gly Asn Met Phe Tyr Val Phe 
        275                 280                 285             


Ser Asp Asp Gly Ile Ile Val Ile His Pro Val Asp Cys Glu Ile Gln 
    290                 295                 300                 


Arg His Leu Lys Pro Thr Glu Lys Ile Phe Met Ser Tyr Glu Glu Ile 
305                 310                 315                 320 


Cys Pro Gln Arg Glu Lys Asn Ala Thr Gln Pro Cys Gln Trp Val Ser 
                325                 330                 335     


Ala Val Asn Val Arg Asn Arg Tyr Ile Tyr Val Ala Gln Pro Ala Leu 
            340                 345                 350         


Ser Arg Val Leu Val Val Asp Ile Gln Ala Gln Lys Val Leu Gln Ser 
        355                 360                 365             


Ile Gly Val Asp Pro Leu Pro Ala Lys Leu Ser Tyr Asp Lys Ser His 
    370                 375                 380                 


Asp Gln Val Trp Val Leu Ser Trp Gly Asp Val His Lys Ser Arg Pro 
385                 390                 395                 400 


Ser Leu Gln Val Ile Thr Glu Ala Ser Thr Gly Gln Ser Gln His Leu 
                405                 410                 415     


Ile Arg Thr Pro Phe Ala Gly Val Asp Asp Phe Phe Ile Pro Pro Thr 
            420                 425                 430         


Asn Leu Ile Ile Asn His Ile Arg Phe Gly Phe Ile Phe Asn Lys Ser 
        435                 440                 445             


Asp Pro Ala Val His Lys Val Asp Leu Glu Thr Met Met Pro Leu Lys 
    450                 455                 460                 


Thr Ile Gly Leu His His His Gly Cys Val Pro Gln Ala Met Ala His 
465                 470                 475                 480 


Thr His Leu Gly Gly Tyr Phe Phe Ile Gln Cys Arg Gln Asp Ser Pro 
                485                 490                 495     


Ala Ser Ala Ala Arg Gln Leu Leu Val Asp Ser Val Thr Asp Ser Val 
            500                 505                 510         


Leu Gly Pro Asn Gly Asp Val Thr Gly Thr Pro His Thr Ser Pro Asp 
        515                 520                 525             


Gly Arg Phe Ile Val Ser Ala Ala Ala Asp Ser Pro Trp Leu His Val 
    530                 535                 540                 


Gln Glu Ile Thr Val Arg Gly Glu Ile Gln Thr Leu Tyr Asp Leu Gln 
545                 550                 555                 560 


Ile Asn Ser Gly Ile Ser Asp Leu Ala Phe Gln Arg Ser Phe Thr Glu 
                565                 570                 575     


Ser Asn Gln Tyr Asn Ile Tyr Ala Ala Leu His Thr Glu Pro Asp Leu 
            580                 585                 590         


Leu Phe Leu Glu Leu Ser Thr Gly Lys Val Gly Met Leu Lys Asn Leu 
        595                 600                 605             


Lys Glu Pro Pro Ala Gly Pro Ala Gln Pro Trp Gly Gly Thr His Arg 
    610                 615                 620                 


Ile Met Arg Asp Ser Gly Leu Phe Gly Gln Tyr Leu Leu Thr Pro Ala 
625                 630                 635                 640 


Arg Glu Ser Leu Phe Leu Ile Asn Gly Arg Gln Asn Thr Leu Arg Cys 
                645                 650                 655     


Glu Val Ser Gly Ile Lys Gly Gly Thr Thr Val Val Trp Val Gly Glu 
            660                 665                 670         


Val 
    


<210>  5585
<211>  842
<212>  PRT
<213>  Homo Sapiens

<400>  5585

Met Lys Pro Gly Gly Phe Trp Leu His Leu Thr Leu Leu Gly Ala Ser 
1               5                   10                  15      


Leu Pro Ala Ala Leu Gly Trp Met Asp Pro Gly Thr Ser Arg Gly Pro 
            20                  25                  30          


Asp Val Gly Val Gly Glu Ser Gln Ala Glu Glu Pro Arg Ser Phe Glu 
        35                  40                  45              


Val Thr Arg Arg Glu Gly Leu Ser Ser His Asn Glu Leu Leu Ala Ser 
    50                  55                  60                  


Cys Gly Lys Lys Phe Cys Ser Arg Gly Ser Arg Cys Val Leu Ser Arg 
65                  70                  75                  80  


Lys Thr Gly Glu Pro Glu Cys Gln Cys Leu Glu Ala Cys Arg Pro Ser 
                85                  90                  95      


Tyr Val Pro Val Cys Gly Ser Asp Gly Arg Phe Tyr Glu Asn His Cys 
            100                 105                 110         


Lys Leu His Arg Ala Ala Cys Leu Leu Gly Lys Arg Ile Thr Val Ile 
        115                 120                 125             


His Ser Lys Asp Cys Phe Leu Lys Gly Asp Thr Cys Thr Met Ala Gly 
    130                 135                 140                 


Tyr Ala Arg Leu Lys Asn Val Leu Leu Ala Leu Gln Thr Arg Leu Gln 
145                 150                 155                 160 


Pro Leu Gln Glu Gly Asp Ser Arg Gln Asp Pro Ala Ser Gln Lys Arg 
                165                 170                 175     


Leu Leu Val Glu Ser Leu Phe Arg Asp Leu Asp Ala Asp Gly Asn Gly 
            180                 185                 190         


His Leu Ser Ser Ser Glu Leu Ala Gln His Val Leu Lys Lys Gln Asp 
        195                 200                 205             


Leu Asp Glu Asp Leu Leu Gly Cys Ser Pro Gly Asp Leu Leu Arg Phe 
    210                 215                 220                 


Asp Asp Tyr Asn Ser Asp Ser Ser Leu Thr Leu Arg Glu Phe Tyr Met 
225                 230                 235                 240 


Ala Phe Gln Val Val Gln Leu Ser Leu Ala Pro Glu Asp Arg Val Ser 
                245                 250                 255     


Val Thr Thr Val Thr Val Gly Leu Ser Thr Val Leu Thr Cys Ala Val 
            260                 265                 270         


His Gly Asp Leu Arg Pro Pro Ile Ile Trp Lys Arg Asn Gly Leu Thr 
        275                 280                 285             


Leu Asn Phe Leu Asp Leu Glu Asp Ile Asn Asp Phe Gly Glu Asp Asp 
    290                 295                 300                 


Ser Leu Tyr Ile Thr Lys Val Thr Thr Ile His Met Gly Asn Tyr Thr 
305                 310                 315                 320 


Cys His Ala Ser Gly His Glu Gln Leu Phe Gln Thr His Val Leu Gln 
                325                 330                 335     


Val Asn Val Pro Pro Val Ile Arg Val Tyr Pro Glu Ser Gln Ala Gln 
            340                 345                 350         


Glu Pro Gly Val Ala Ala Ser Leu Arg Cys His Ala Glu Gly Ile Pro 
        355                 360                 365             


Met Pro Arg Ile Thr Trp Leu Lys Asn Gly Val Asp Val Ser Thr Gln 
    370                 375                 380                 


Met Ser Lys Gln Leu Ser Leu Leu Ala Asn Gly Ser Glu Leu His Ile 
385                 390                 395                 400 


Ser Ser Val Arg Tyr Glu Asp Thr Gly Ala Tyr Thr Cys Ile Ala Lys 
                405                 410                 415     


Asn Glu Val Gly Val Asp Glu Asp Ile Ser Ser Leu Phe Ile Glu Asp 
            420                 425                 430         


Ser Ala Arg Lys Thr Leu Ala Asn Ile Leu Trp Arg Glu Glu Gly Leu 
        435                 440                 445             


Ser Val Gly Asn Met Phe Tyr Val Phe Ser Asp Asp Gly Ile Ile Val 
    450                 455                 460                 


Ile His Pro Val Asp Cys Glu Ile Gln Arg His Leu Lys Pro Thr Glu 
465                 470                 475                 480 


Lys Ile Phe Met Ser Tyr Glu Glu Ile Cys Pro Gln Arg Glu Lys Asn 
                485                 490                 495     


Ala Thr Gln Pro Cys Gln Trp Val Ser Ala Val Asn Val Arg Asn Arg 
            500                 505                 510         


Tyr Ile Tyr Val Ala Gln Pro Ala Leu Ser Arg Val Leu Val Val Asp 
        515                 520                 525             


Ile Gln Ala Gln Lys Val Leu Gln Ser Ile Gly Val Asp Pro Leu Pro 
    530                 535                 540                 


Ala Lys Leu Ser Tyr Asp Lys Ser His Asp Gln Val Trp Val Leu Ser 
545                 550                 555                 560 


Trp Gly Asp Val His Lys Ser Arg Pro Ser Leu Gln Val Ile Thr Glu 
                565                 570                 575     


Ala Ser Thr Gly Gln Ser Gln His Leu Ile Arg Thr Pro Phe Ala Gly 
            580                 585                 590         


Val Asp Asp Phe Phe Ile Pro Pro Thr Asn Leu Ile Ile Asn His Ile 
        595                 600                 605             


Arg Phe Gly Phe Ile Phe Asn Lys Ser Asp Pro Ala Val His Lys Val 
    610                 615                 620                 


Asp Leu Glu Thr Met Met Pro Leu Lys Thr Ile Gly Leu His His His 
625                 630                 635                 640 


Gly Cys Val Pro Gln Ala Met Ala His Thr His Leu Gly Gly Tyr Phe 
                645                 650                 655     


Phe Ile Gln Cys Arg Gln Asp Ser Pro Ala Ser Ala Ala Arg Gln Leu 
            660                 665                 670         


Leu Val Asp Ser Val Thr Asp Ser Val Leu Gly Pro Asn Gly Asp Val 
        675                 680                 685             


Thr Gly Thr Pro His Thr Ser Pro Asp Gly Arg Phe Ile Val Ser Ala 
    690                 695                 700                 


Ala Ala Asp Ser Pro Trp Leu His Val Gln Glu Ile Thr Val Arg Gly 
705                 710                 715                 720 


Glu Ile Gln Thr Leu Tyr Asp Leu Gln Ile Asn Ser Gly Ile Ser Asp 
                725                 730                 735     


Leu Ala Phe Gln Arg Ser Phe Thr Glu Ser Asn Gln Tyr Asn Ile Tyr 
            740                 745                 750         


Ala Ala Leu His Thr Glu Pro Asp Leu Leu Phe Leu Glu Leu Ser Thr 
        755                 760                 765             


Gly Lys Val Gly Met Leu Lys Asn Leu Lys Glu Pro Pro Ala Gly Pro 
    770                 775                 780                 


Ala Gln Pro Trp Gly Gly Thr His Arg Ile Met Arg Asp Ser Gly Leu 
785                 790                 795                 800 


Phe Gly Gln Tyr Leu Leu Thr Pro Ala Arg Glu Ser Leu Phe Leu Ile 
                805                 810                 815     


Asn Gly Arg Gln Asn Thr Leu Arg Cys Glu Val Ser Gly Ile Lys Gly 
            820                 825                 830         


Gly Thr Thr Val Val Trp Val Gly Glu Val 
        835                 840         


<210>  5586
<211>  157
<212>  PRT
<213>  Homo Sapiens

<400>  5586

Met Asn Pro Val Pro Gln Met Glu Met Gln Lys Ser Pro Val Phe Cys 
1               5                   10                  15      


Val Ala His Ala Gly Ser Cys Arg Pro Glu Leu Phe Leu Phe Gly His 
            20                  25                  30          


Leu Gly Ser Ser Trp Gly Leu Asp Leu Lys Glu Glu Glu Pro Arg Ser 
        35                  40                  45              


Phe Glu Val Thr Arg Arg Glu Gly Leu Ser Ser His Asn Glu Leu Leu 
    50                  55                  60                  


Ala Ser Cys Gly Lys Lys Phe Cys Ser Arg Gly Ser Arg Cys Val Leu 
65                  70                  75                  80  


Ser Arg Lys Thr Gly Glu Pro Glu Cys Gln Cys Leu Glu Ala Cys Arg 
                85                  90                  95      


Pro Ser Tyr Val Pro Val Cys Gly Ser Asp Gly Arg Phe Tyr Glu Asn 
            100                 105                 110         


His Cys Lys Leu His Arg Ala Ala Cys Leu Leu Gly Lys Arg Ile Thr 
        115                 120                 125             


Val Ile His Ser Lys Asp Cys Phe Leu Lys Gly Asp Thr Cys Thr Met 
    130                 135                 140                 


Ala Gly Tyr Ala Arg Leu Lys Asn Val Leu Leu Ala Leu 
145                 150                 155         


<210>  5587
<211>  846
<212>  PRT
<213>  Homo Sapiens

<400>  5587

Met Phe Lys Cys Trp Ser Val Val Leu Val Leu Gly Phe Ile Phe Leu 
1               5                   10                  15      


Glu Ser Glu Gly Arg Pro Thr Lys Glu Gly Gly Tyr Gly Leu Lys Ser 
            20                  25                  30          


Tyr Gln Pro Leu Met Arg Leu Arg His Lys Glu Lys Asn Gln Glu Ser 
        35                  40                  45              


Ser Arg Val Lys Gly Phe Met Ile Gln Asp Gly Pro Phe Gly Ser Cys 
    50                  55                  60                  


Glu Asn Lys Tyr Cys Gly Leu Gly Arg His Cys Val Thr Ser Arg Glu 
65                  70                  75                  80  


Thr Gly Gln Ala Glu Cys Ala Cys Met Asp Leu Cys Lys Arg His Tyr 
                85                  90                  95      


Lys Pro Val Cys Gly Ser Asp Gly Glu Phe Tyr Glu Asn His Cys Glu 
            100                 105                 110         


Val His Arg Ala Ala Cys Leu Lys Lys Gln Lys Ile Thr Ile Val His 
        115                 120                 125             


Asn Glu Asp Cys Phe Phe Lys Gly Asp Lys Cys Lys Thr Thr Glu Tyr 
    130                 135                 140                 


Ser Lys Met Lys Asn Met Leu Leu Asp Leu Gln Asn Gln Lys Tyr Ile 
145                 150                 155                 160 


Met Gln Glu Asn Glu Asn Pro Asn Gly Asp Asp Ile Ser Arg Lys Lys 
                165                 170                 175     


Leu Leu Val Asp Gln Met Phe Lys Tyr Phe Asp Ala Asp Ser Asn Gly 
            180                 185                 190         


Leu Val Asp Ile Asn Glu Leu Thr Gln Val Ile Lys Gln Glu Glu Leu 
        195                 200                 205             


Gly Lys Asp Leu Phe Asp Cys Thr Leu Tyr Val Leu Leu Lys Tyr Asp 
    210                 215                 220                 


Asp Phe Asn Ala Asp Lys His Leu Ala Leu Glu Glu Phe Tyr Arg Ala 
225                 230                 235                 240 


Phe Gln Val Ile Gln Leu Ser Leu Pro Glu Asp Gln Lys Leu Ser Ile 
                245                 250                 255     


Thr Ala Ala Thr Val Gly Gln Ser Ala Val Leu Ser Cys Ala Ile Gln 
            260                 265                 270         


Gly Thr Leu Arg Pro Pro Ile Ile Trp Lys Arg Asn Asn Ile Ile Leu 
        275                 280                 285             


Asn Asn Leu Asp Leu Glu Asp Ile Asn Asp Phe Gly Asp Asp Gly Ser 
    290                 295                 300                 


Leu Tyr Ile Thr Lys Val Thr Thr Thr His Val Gly Asn Tyr Thr Cys 
305                 310                 315                 320 


Tyr Ala Asp Gly Tyr Glu Gln Val Tyr Gln Thr His Ile Phe Gln Val 
                325                 330                 335     


Asn Val Pro Pro Val Ile Arg Val Tyr Pro Glu Ser Gln Ala Arg Glu 
            340                 345                 350         


Pro Gly Val Thr Ala Ser Leu Arg Cys His Ala Glu Gly Ile Pro Lys 
        355                 360                 365             


Pro Gln Leu Gly Trp Leu Lys Asn Gly Ile Asp Ile Thr Pro Lys Leu 
    370                 375                 380                 


Ser Lys Gln Leu Thr Leu Gln Ala Asn Gly Ser Glu Val His Ile Ser 
385                 390                 395                 400 


Asn Val Arg Tyr Glu Asp Thr Gly Ala Tyr Thr Cys Ile Ala Lys Asn 
                405                 410                 415     


Glu Ala Gly Val Asp Glu Asp Ile Ser Ser Leu Phe Val Glu Asp Ser 
            420                 425                 430         


Ala Arg Lys Thr Leu Ala Asn Ile Leu Trp Arg Glu Glu Gly Leu Gly 
        435                 440                 445             


Ile Gly Asn Met Phe Tyr Val Phe Tyr Glu Asp Gly Ile Lys Val Ile 
    450                 455                 460                 


Gln Pro Ile Glu Cys Glu Phe Gln Arg His Ile Lys Pro Ser Glu Lys 
465                 470                 475                 480 


Leu Leu Gly Phe Gln Asp Glu Val Cys Pro Lys Ala Glu Gly Asp Glu 
                485                 490                 495     


Val Gln Arg Cys Val Trp Ala Ser Ala Val Asn Val Lys Asp Lys Phe 
            500                 505                 510         


Ile Tyr Val Ala Gln Pro Thr Leu Asp Arg Val Leu Ile Val Asp Val 
        515                 520                 525             


Gln Ser Gln Lys Val Val Gln Ala Val Ser Thr Asp Pro Val Pro Val 
    530                 535                 540                 


Lys Leu His Tyr Asp Lys Ser His Asp Gln Val Trp Val Leu Ser Trp 
545                 550                 555                 560 


Gly Thr Leu Glu Lys Thr Ser Pro Thr Leu Gln Val Ile Thr Leu Ala 
                565                 570                 575     


Ser Gly Asn Val Pro His His Thr Ile His Thr Gln Pro Val Gly Lys 
            580                 585                 590         


Gln Phe Asp Arg Val Asp Asp Phe Phe Ile Pro Thr Thr Thr Leu Ile 
        595                 600                 605             


Ile Thr His Met Arg Phe Gly Phe Ile Leu His Lys Asp Glu Ala Ala 
    610                 615                 620                 


Leu Gln Lys Ile Asp Leu Glu Thr Met Ser Tyr Ile Lys Thr Ile Asn 
625                 630                 635                 640 


Leu Lys Asp Tyr Lys Cys Val Pro Gln Ser Leu Ala Tyr Thr His Leu 
                645                 650                 655     


Gly Gly Tyr Tyr Phe Ile Gly Cys Lys Pro Asp Ser Thr Gly Ala Val 
            660                 665                 670         


Ser Pro Gln Val Met Val Asp Gly Val Thr Asp Ser Val Ile Gly Phe 
        675                 680                 685             


Asn Ser Asp Val Thr Gly Thr Pro Tyr Val Ser Pro Asp Gly His Tyr 
    690                 695                 700                 


Leu Val Ser Ile Asn Asp Val Lys Gly Leu Val Arg Val Gln Tyr Ile 
705                 710                 715                 720 


Thr Ile Arg Gly Glu Ile Gln Glu Ala Phe Asp Ile Tyr Thr Asn Leu 
                725                 730                 735     


His Ile Ser Asp Leu Ala Phe Gln Pro Ser Phe Thr Glu Ala His Gln 
            740                 745                 750         


Tyr Asn Ile Tyr Gly Ser Ser Ser Thr Gln Thr Asp Val Leu Phe Val 
        755                 760                 765             


Glu Leu Ser Ser Gly Lys Val Lys Met Ile Lys Ser Leu Lys Glu Pro 
    770                 775                 780                 


Leu Lys Ala Glu Glu Trp Pro Trp Asn Arg Lys Asn Arg Gln Ile Gln 
785                 790                 795                 800 


Asp Ser Gly Leu Phe Gly Gln Tyr Leu Met Thr Pro Ser Lys Asp Ser 
                805                 810                 815     


Leu Phe Ile Leu Asp Gly Arg Leu Asn Lys Leu Asn Cys Glu Ile Thr 
            820                 825                 830         


Glu Val Glu Lys Gly Asn Thr Val Ile Trp Val Gly Asp Ala 
        835                 840                 845     


<210>  5588
<211>  837
<212>  PRT
<213>  Homo Sapiens

<400>  5588

Met Phe Lys Cys Trp Ser Val Val Leu Val Leu Gly Phe Ile Phe Leu 
1               5                   10                  15      


Glu Ser Glu Gly Arg Pro Thr Lys Glu Gly Gly Tyr Gly Leu Lys Ser 
            20                  25                  30          


Tyr Gln Pro Leu Met Arg Leu Arg His Lys Glu Lys Asn Gln Glu Ser 
        35                  40                  45              


Ser Arg Val Lys Gly Phe Met Ile Gln Asp Gly Pro Phe Gly Ser Cys 
    50                  55                  60                  


Glu Asn Lys Tyr Cys Gly Leu Gly Arg His Cys Val Thr Ser Arg Glu 
65                  70                  75                  80  


Thr Gly Gln Ala Glu Cys Ala Cys Met Asp Leu Cys Lys Arg His Tyr 
                85                  90                  95      


Lys Pro Val Cys Gly Ser Asp Gly Glu Phe Tyr Glu Asn His Cys Glu 
            100                 105                 110         


Val His Arg Ala Ala Cys Leu Lys Lys Gln Lys Ile Thr Ile Val His 
        115                 120                 125             


Asn Glu Asp Cys Phe Phe Lys Gly Asp Lys Cys Lys Thr Thr Glu Tyr 
    130                 135                 140                 


Ser Lys Met Lys Asn Met Leu Leu Asp Leu Gln Asn Gln Lys Tyr Ile 
145                 150                 155                 160 


Met Gln Glu Asn Glu Asn Pro Asn Gly Asp Asp Ile Ser Arg Lys Lys 
                165                 170                 175     


Leu Leu Val Asp Gln Met Phe Lys Tyr Phe Asp Ala Asp Ser Asn Gly 
            180                 185                 190         


Leu Val Asp Ile Asn Glu Leu Thr Gln Val Ile Lys Gln Glu Glu Leu 
        195                 200                 205             


Gly Lys Asp Leu Phe Asp Cys Thr Leu Tyr Val Leu Leu Lys Tyr Asp 
    210                 215                 220                 


Asp Phe Asn Ala Asp Lys His Leu Ala Leu Glu Glu Phe Tyr Arg Ala 
225                 230                 235                 240 


Phe Gln Val Ile Gln Leu Ser Leu Pro Glu Asp Gln Lys Leu Ser Ile 
                245                 250                 255     


Thr Ala Ala Thr Val Gly Gln Ser Ala Val Leu Ser Cys Ala Ile Gln 
            260                 265                 270         


Gly Thr Leu Arg Pro Pro Ile Ile Trp Lys Arg Asn Asn Ile Ile Leu 
        275                 280                 285             


Asn Asn Leu Asp Leu Glu Asp Ile Asn Asp Phe Gly Asp Asp Gly Ser 
    290                 295                 300                 


Leu Tyr Ile Thr Lys Val Thr Thr Thr His Val Gly Asn Tyr Thr Cys 
305                 310                 315                 320 


Tyr Ala Asp Gly Tyr Glu Gln Val Tyr Gln Thr His Ile Phe Gln Val 
                325                 330                 335     


Asn Val Pro Pro Val Ile Arg Val Tyr Pro Glu Ser Gln Ala Arg Glu 
            340                 345                 350         


Pro Gly Val Thr Ala Ser Leu Arg Cys His Ala Glu Gly Ile Pro Lys 
        355                 360                 365             


Pro Gln Leu Gly Trp Leu Lys Asn Gly Ile Asp Ile Thr Pro Lys Leu 
    370                 375                 380                 


Ser Lys Gln Leu Thr Leu Gln Ala Asn Gly Ser Glu Val His Ile Ser 
385                 390                 395                 400 


Asn Val Arg Tyr Glu Asp Thr Gly Ala Tyr Thr Cys Ile Ala Lys Asn 
                405                 410                 415     


Glu Ala Gly Val Asp Glu Asp Ile Ser Ser Leu Phe Val Glu Asp Ser 
            420                 425                 430         


Ala Arg Lys Thr Arg Leu Gly Ile Gly Asn Met Phe Tyr Val Phe Tyr 
        435                 440                 445             


Glu Asp Gly Ile Lys Val Ile Gln Pro Ile Glu Cys Glu Phe Gln Arg 
    450                 455                 460                 


His Ile Lys Pro Ser Glu Lys Leu Leu Gly Phe Gln Asp Glu Val Cys 
465                 470                 475                 480 


Pro Lys Ala Glu Gly Asp Glu Val Gln Arg Cys Val Trp Ala Ser Ala 
                485                 490                 495     


Val Asn Val Lys Asp Lys Phe Ile Tyr Val Ala Gln Pro Thr Leu Asp 
            500                 505                 510         


Arg Val Leu Ile Val Asp Val Gln Ser Gln Lys Val Val Gln Ala Val 
        515                 520                 525             


Ser Thr Asp Pro Val Pro Val Lys Leu His Tyr Asp Lys Ser His Asp 
    530                 535                 540                 


Gln Val Trp Val Leu Ser Trp Gly Thr Leu Glu Lys Thr Ser Pro Thr 
545                 550                 555                 560 


Leu Gln Val Ile Thr Leu Ala Ser Gly Asn Val Pro His His Thr Ile 
                565                 570                 575     


His Thr Gln Pro Val Gly Lys Gln Phe Asp Arg Val Asp Asp Phe Phe 
            580                 585                 590         


Ile Pro Thr Thr Thr Leu Ile Ile Thr His Met Arg Phe Gly Phe Ile 
        595                 600                 605             


Leu His Lys Asp Glu Ala Ala Leu Gln Lys Ile Asp Leu Glu Thr Met 
    610                 615                 620                 


Ser Tyr Ile Lys Thr Ile Asn Leu Lys Asp Tyr Lys Cys Val Pro Gln 
625                 630                 635                 640 


Ser Leu Ala Tyr Thr His Leu Gly Gly Tyr Tyr Phe Ile Gly Cys Lys 
                645                 650                 655     


Pro Asp Ser Thr Gly Ala Val Ser Pro Gln Val Met Val Asp Gly Val 
            660                 665                 670         


Thr Asp Ser Val Ile Gly Phe Asn Ser Asp Val Thr Gly Thr Pro Tyr 
        675                 680                 685             


Val Ser Pro Asp Gly His Tyr Leu Val Ser Ile Asn Asp Val Lys Gly 
    690                 695                 700                 


Leu Val Arg Val Gln Tyr Ile Thr Ile Arg Gly Glu Ile Gln Glu Ala 
705                 710                 715                 720 


Phe Asp Ile Tyr Thr Asn Leu His Ile Ser Asp Leu Ala Phe Gln Pro 
                725                 730                 735     


Ser Phe Thr Glu Ala His Gln Tyr Asn Ile Tyr Gly Ser Ser Ser Thr 
            740                 745                 750         


Gln Thr Asp Val Leu Phe Val Glu Leu Ser Ser Gly Lys Val Lys Met 
        755                 760                 765             


Ile Lys Ser Leu Lys Glu Pro Leu Lys Ala Glu Glu Trp Pro Trp Asn 
    770                 775                 780                 


Arg Lys Asn Arg Gln Ile Gln Asp Ser Gly Leu Phe Gly Gln Tyr Leu 
785                 790                 795                 800 


Met Thr Pro Ser Lys Asp Ser Leu Phe Ile Leu Asp Gly Arg Leu Asn 
                805                 810                 815     


Lys Leu Asn Cys Glu Ile Thr Glu Val Glu Lys Gly Asn Thr Val Ile 
            820                 825                 830         


Trp Val Gly Asp Ala 
        835         


<210>  5589
<211>  847
<212>  PRT
<213>  Homo Sapiens

<400>  5589

Met Phe Lys Cys Trp Ser Val Val Leu Val Leu Gly Phe Ile Phe Leu 
1               5                   10                  15      


Glu Ser Glu Gly Arg Pro Thr Lys Glu Gly Gly Tyr Gly Leu Lys Ser 
            20                  25                  30          


Tyr Gln Pro Leu Met Arg Leu Arg His Lys Gln Glu Lys Asn Gln Glu 
        35                  40                  45              


Ser Ser Arg Val Lys Gly Phe Met Ile Gln Asp Gly Pro Phe Gly Ser 
    50                  55                  60                  


Cys Glu Asn Lys Tyr Cys Gly Leu Gly Arg His Cys Val Thr Ser Arg 
65                  70                  75                  80  


Glu Thr Gly Gln Ala Glu Cys Ala Cys Met Asp Leu Cys Lys Arg His 
                85                  90                  95      


Tyr Lys Pro Val Cys Gly Ser Asp Gly Glu Phe Tyr Glu Asn His Cys 
            100                 105                 110         


Glu Val His Arg Ala Ala Cys Leu Lys Lys Gln Lys Ile Thr Ile Val 
        115                 120                 125             


His Asn Glu Asp Cys Phe Phe Lys Gly Asp Lys Cys Lys Thr Thr Glu 
    130                 135                 140                 


Tyr Ser Lys Met Lys Asn Met Leu Leu Asp Leu Gln Asn Gln Lys Tyr 
145                 150                 155                 160 


Ile Met Gln Glu Asn Glu Asn Pro Asn Gly Asp Asp Ile Ser Arg Lys 
                165                 170                 175     


Lys Leu Leu Val Asp Gln Met Phe Lys Tyr Phe Asp Ala Asp Ser Asn 
            180                 185                 190         


Gly Leu Val Asp Ile Asn Glu Leu Thr Gln Val Ile Lys Gln Glu Glu 
        195                 200                 205             


Leu Gly Lys Asp Leu Phe Asp Cys Thr Leu Tyr Val Leu Leu Lys Tyr 
    210                 215                 220                 


Asp Asp Phe Asn Ala Asp Lys His Leu Ala Leu Glu Glu Phe Tyr Arg 
225                 230                 235                 240 


Ala Phe Gln Val Ile Gln Leu Ser Leu Pro Glu Asp Gln Lys Leu Ser 
                245                 250                 255     


Ile Thr Ala Ala Thr Val Gly Gln Ser Ala Val Leu Ser Cys Ala Ile 
            260                 265                 270         


Gln Gly Thr Leu Arg Pro Pro Ile Ile Trp Lys Arg Asn Asn Ile Ile 
        275                 280                 285             


Leu Asn Asn Leu Asp Leu Glu Asp Ile Asn Asp Phe Gly Asp Asp Gly 
    290                 295                 300                 


Ser Leu Tyr Ile Thr Lys Val Thr Thr Thr His Val Gly Asn Tyr Thr 
305                 310                 315                 320 


Cys Tyr Ala Asp Gly Tyr Glu Gln Val Tyr Gln Thr His Ile Phe Gln 
                325                 330                 335     


Val Asn Val Pro Pro Val Ile Arg Val Tyr Pro Glu Ser Gln Ala Arg 
            340                 345                 350         


Glu Pro Gly Val Thr Ala Ser Leu Arg Cys His Ala Glu Gly Ile Pro 
        355                 360                 365             


Lys Pro Gln Leu Gly Trp Leu Lys Asn Gly Ile Asp Ile Thr Pro Lys 
    370                 375                 380                 


Leu Ser Lys Gln Leu Thr Leu Gln Ala Asn Gly Ser Glu Val His Ile 
385                 390                 395                 400 


Ser Asn Val Arg Tyr Glu Asp Thr Gly Ala Tyr Thr Cys Ile Ala Lys 
                405                 410                 415     


Asn Glu Ala Gly Val Asp Glu Asp Ile Ser Ser Leu Phe Val Glu Asp 
            420                 425                 430         


Ser Ala Arg Lys Thr Leu Ala Asn Ile Leu Trp Arg Glu Glu Gly Leu 
        435                 440                 445             


Gly Ile Gly Asn Met Phe Tyr Val Phe Tyr Glu Asp Gly Ile Lys Val 
    450                 455                 460                 


Ile Gln Pro Ile Glu Cys Glu Phe Gln Arg His Ile Lys Pro Ser Glu 
465                 470                 475                 480 


Lys Leu Leu Gly Phe Gln Asp Glu Val Cys Pro Lys Ala Glu Gly Asp 
                485                 490                 495     


Glu Val Gln Arg Cys Val Trp Ala Ser Ala Val Asn Val Lys Asp Lys 
            500                 505                 510         


Phe Ile Tyr Val Ala Gln Pro Thr Leu Asp Arg Val Leu Ile Val Asp 
        515                 520                 525             


Val Gln Ser Gln Lys Val Val Gln Ala Val Ser Thr Asp Pro Val Pro 
    530                 535                 540                 


Val Lys Leu His Tyr Asp Lys Ser His Asp Gln Val Trp Val Leu Ser 
545                 550                 555                 560 


Trp Gly Thr Leu Glu Lys Thr Ser Pro Thr Leu Gln Val Ile Thr Leu 
                565                 570                 575     


Ala Ser Gly Asn Val Pro His His Thr Ile His Thr Gln Pro Val Gly 
            580                 585                 590         


Lys Gln Phe Asp Arg Val Asp Asp Phe Phe Ile Pro Thr Thr Thr Leu 
        595                 600                 605             


Ile Ile Thr His Met Arg Phe Gly Phe Ile Leu His Lys Asp Glu Ala 
    610                 615                 620                 


Ala Leu Gln Lys Ile Asp Leu Glu Thr Met Ser Tyr Ile Lys Thr Ile 
625                 630                 635                 640 


Asn Leu Lys Asp Tyr Lys Cys Val Pro Gln Ser Leu Ala Tyr Thr His 
                645                 650                 655     


Leu Gly Gly Tyr Tyr Phe Ile Gly Cys Lys Pro Asp Ser Thr Gly Ala 
            660                 665                 670         


Val Ser Pro Gln Val Met Val Asp Gly Val Thr Asp Ser Val Ile Gly 
        675                 680                 685             


Phe Asn Ser Asp Val Thr Gly Thr Pro Tyr Val Ser Pro Asp Gly His 
    690                 695                 700                 


Tyr Leu Val Ser Ile Asn Asp Val Lys Gly Leu Val Arg Val Gln Tyr 
705                 710                 715                 720 


Ile Thr Ile Arg Gly Glu Ile Gln Glu Ala Phe Asp Ile Tyr Thr Asn 
                725                 730                 735     


Leu His Ile Ser Asp Leu Ala Phe Gln Pro Ser Phe Thr Glu Ala His 
            740                 745                 750         


Gln Tyr Asn Ile Tyr Gly Ser Ser Ser Thr Gln Thr Asp Val Leu Phe 
        755                 760                 765             


Val Glu Leu Ser Ser Gly Lys Val Lys Met Ile Lys Ser Leu Lys Glu 
    770                 775                 780                 


Pro Leu Lys Ala Glu Glu Trp Pro Trp Asn Arg Lys Asn Arg Gln Ile 
785                 790                 795                 800 


Gln Asp Ser Gly Leu Phe Gly Gln Tyr Leu Met Thr Pro Ser Lys Asp 
                805                 810                 815     


Ser Leu Phe Ile Leu Asp Gly Arg Leu Asn Lys Leu Asn Cys Glu Ile 
            820                 825                 830         


Thr Glu Val Glu Lys Gly Asn Thr Val Ile Trp Val Gly Asp Ala 
        835                 840                 845         


<210>  5590
<211>  138
<212>  PRT
<213>  Homo Sapiens

<400>  5590

Met Ser Ser Ser Arg Val Gly Leu Arg Leu Ala Ala Cys Leu Leu Asn 
1               5                   10                  15      


Val Ser Glu Ala Gly Arg Lys Tyr Ile Val Glu Asn Ile Ala Lys Ala 
            20                  25                  30          


Ala Leu Leu Asp Lys Asn Gly Lys Lys His Pro Gln Val Ser Val Leu 
        35                  40                  45              


Asn Ile Phe Ser Asp Gln Asp Tyr Lys Arg Ser Val Ile Thr Ile Ala 
    50                  55                  60                  


Thr Ser Val Asp Lys Leu Gly Leu Ala Glu Asp Leu Val Leu His Val 
65                  70                  75                  80  


Pro Gly Cys Ser Val Phe Leu Phe Gly Glu Ala Asp Leu Pro Glu Lys 
                85                  90                  95      


Arg Ser Leu Val Gln Arg Arg Lys Gln Leu Gly Trp Phe Thr Arg Arg 
            100                 105                 110         


Asp Phe Ser Ala Leu Gln Pro Asp Leu Gly Ala Ala Pro Ser Gln Arg 
        115                 120                 125             


Cys Gly Leu Thr Ala Cys Phe Arg Ala Leu 
    130                 135             


<210>  5591
<211>  147
<212>  PRT
<213>  Homo Sapiens

<400>  5591

Met Ser Ser Ser Arg Val Gly Leu Arg Leu Ala Ala Cys Leu Leu Asn 
1               5                   10                  15      


Val Ser Glu Ala Gly Arg Lys Tyr Ile Val Glu Asn Ile Ala Lys Ala 
            20                  25                  30          


Ala Leu Leu Asp Lys Asn Gly Lys Lys His Pro Gln Val Ser Val Leu 
        35                  40                  45              


Asn Ile Phe Ser Asp Gln Asp Tyr Lys Arg Ser Val Ile Thr Ile Ala 
    50                  55                  60                  


Thr Ser Val Asp Lys Leu Gly Leu Ala Glu Asp Leu Val Leu His Val 
65                  70                  75                  80  


Pro Gly Cys Ser Val Phe Leu Phe Gly Glu Ala Asp Leu Pro Glu Lys 
                85                  90                  95      


Arg Ser Leu Val Gln Arg Arg Lys Gln Leu Gly Trp Phe Thr Arg Arg 
            100                 105                 110         


Asp Phe Ser Ala Leu Gln Pro Asp Leu Gly Ala Ala Pro Ser Gln Arg 
        115                 120                 125             


Cys Gly Leu Thr Gly Ser Glu His Gly Phe Cys Phe Ala Leu Phe Phe 
    130                 135                 140                 


Phe Phe Phe 
145         


<210>  5592
<211>  114
<212>  PRT
<213>  Homo Sapiens

<400>  5592

Met Ser Ser Ser Arg Val Gly Leu Arg Leu Ala Ala Cys Leu Leu Asn 
1               5                   10                  15      


Val Ser Glu Ala Gly Arg Lys Tyr Ile Val Glu Asn Ile Ala Lys Ala 
            20                  25                  30          


Ala Leu Leu Asp Lys Asn Gly Lys Lys His Pro Gln Val Ser Val Leu 
        35                  40                  45              


Asn Ile Phe Ser Asp Gln Asp Tyr Lys Arg Ser Val Ile Thr Ile Ala 
    50                  55                  60                  


Thr Ser Val Asp Lys Leu Gly Ser Ser Val Leu Ala Ala Cys Leu Glu 
65                  70                  75                  80  


Ala Phe Gln Ala Ile Asp Met Glu Val Gln Glu Gly Ile His Pro Cys 
                85                  90                  95      


Leu Gly Ala Val Asp Leu Ile Pro Ile Tyr Pro Leu Ser Gly Val Thr 
            100                 105                 110         


Val Glu 
        


<210>  5593
<211>  77
<212>  PRT
<213>  Homo Sapiens

<400>  5593

Met Ser Ser Ser Arg Val Gly Leu Arg Leu Ala Ala Cys Leu Leu Asn 
1               5                   10                  15      


Val Ser Glu Ala Gly Arg Lys Tyr Ile Val Glu Asn Ile Ala Lys Ala 
            20                  25                  30          


Ala Leu Leu Asp Lys Asn Gly Lys Lys His Pro Gln Val Ser Val Leu 
        35                  40                  45              


Asn Ile Phe Ser Asp Gln Asp Tyr Lys Arg Ser Val Ile Thr Ile Ala 
    50                  55                  60                  


Thr Ser Val Asp Lys Leu Val Asp Lys Arg Asn Gln Ala 
65                  70                  75          


<210>  5594
<211>  466
<212>  PRT
<213>  Homo Sapiens

<400>  5594

Met Arg Ala Pro Gly Met Arg Ser Arg Pro Ala Gly Pro Ala Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Phe Leu Gly Ala Ala Glu Ser Val Arg Arg Ala Gln 
            20                  25                  30          


Pro Pro Arg Arg Tyr Thr Pro Asp Trp Pro Ser Leu Asp Ser Arg Pro 
        35                  40                  45              


Leu Pro Ala Trp Phe Asp Glu Ala Lys Phe Gly Val Phe Ile His Trp 
    50                  55                  60                  


Gly Val Phe Ser Val Pro Ala Trp Gly Ser Glu Trp Phe Trp Trp His 
65                  70                  75                  80  


Trp Gln Gly Glu Gly Arg Pro Gln Tyr Gln Arg Phe Met Arg Asp Asn 
                85                  90                  95      


Tyr Pro Pro Gly Phe Ser Tyr Ala Asp Phe Gly Pro Gln Phe Thr Ala 
            100                 105                 110         


Arg Phe Phe His Pro Glu Glu Trp Ala Asp Leu Phe Gln Ala Ala Gly 
        115                 120                 125             


Ala Lys Tyr Val Val Leu Thr Thr Lys His His Glu Gly Phe Thr Asn 
    130                 135                 140                 


Trp Pro Ser Pro Val Ser Trp Asn Trp Asn Ser Lys Asp Val Gly Pro 
145                 150                 155                 160 


His Arg Asp Leu Val Gly Glu Leu Gly Thr Ala Leu Arg Lys Arg Asn 
                165                 170                 175     


Ile Arg Tyr Gly Leu Tyr His Ser Leu Leu Glu Trp Phe His Pro Leu 
            180                 185                 190         


Tyr Leu Leu Asp Lys Lys Asn Gly Phe Lys Thr Gln His Phe Val Ser 
        195                 200                 205             


Ala Lys Thr Met Pro Glu Leu Tyr Asp Leu Val Asn Ser Tyr Lys Pro 
    210                 215                 220                 


Asp Leu Ile Trp Ser Asp Gly Glu Trp Glu Cys Pro Asp Thr Tyr Trp 
225                 230                 235                 240 


Asn Ser Thr Asn Phe Leu Ser Trp Leu Tyr Asn Asp Ser Pro Val Lys 
                245                 250                 255     


Asp Glu Val Val Val Asn Asp Arg Trp Gly Gln Asn Cys Ser Cys His 
            260                 265                 270         


His Gly Gly Tyr Tyr Asn Cys Glu Asp Lys Phe Lys Pro Gln Ser Leu 
        275                 280                 285             


Pro Asp His Lys Trp Glu Met Cys Thr Ser Ile Asp Lys Phe Ser Trp 
    290                 295                 300                 


Gly Tyr Arg Arg Asp Met Ala Leu Ser Asp Val Thr Glu Glu Ser Glu 
305                 310                 315                 320 


Ile Ile Ser Glu Leu Val Gln Thr Val Ser Leu Gly Gly Asn Tyr Leu 
                325                 330                 335     


Leu Asn Ile Gly Pro Thr Lys Asp Gly Leu Ile Val Pro Ile Phe Gln 
            340                 345                 350         


Glu Arg Leu Leu Ala Val Gly Lys Trp Leu Ser Ile Asn Gly Glu Ala 
        355                 360                 365             


Ile Tyr Ala Ser Lys Pro Trp Arg Val Gln Trp Glu Lys Asn Thr Thr 
    370                 375                 380                 


Ser Val Trp Tyr Thr Ser Lys Gly Ser Ala Val Tyr Ala Ile Phe Leu 
385                 390                 395                 400 


His Trp Pro Glu Asn Gly Val Leu Asn Leu Glu Ser Pro Ile Thr Thr 
                405                 410                 415     


Ser Thr Thr Lys Ile Thr Met Leu Gly Ile Gln Gly Asp Leu Lys Trp 
            420                 425                 430         


Ser Thr Asp Pro Asp Lys Gly Leu Phe Ile Ser Leu Pro Gln Leu Pro 
        435                 440                 445             


Pro Ser Ala Val Pro Ala Glu Phe Ala Trp Thr Ile Lys Leu Thr Gly 
    450                 455                 460                 


Val Lys 
465     


<210>  5595
<211>  467
<212>  PRT
<213>  Homo Sapiens

<400>  5595

Met Arg Pro Gln Glu Leu Pro Arg Leu Ala Phe Pro Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Pro Pro Pro Pro Cys Pro Ala His Ser Ala Thr 
            20                  25                  30          


Arg Phe Asp Pro Thr Trp Glu Ser Leu Asp Ala Arg Gln Leu Pro Ala 
        35                  40                  45              


Trp Phe Asp Gln Ala Lys Phe Gly Ile Phe Ile His Trp Gly Val Phe 
    50                  55                  60                  


Ser Val Pro Ser Phe Gly Ser Glu Trp Phe Trp Trp Tyr Trp Gln Lys 
65                  70                  75                  80  


Glu Lys Ile Pro Lys Tyr Val Glu Phe Met Lys Asp Asn Tyr Pro Pro 
                85                  90                  95      


Ser Phe Lys Tyr Glu Asp Phe Gly Pro Leu Phe Thr Ala Lys Phe Phe 
            100                 105                 110         


Asn Ala Asn Gln Trp Ala Asp Ile Phe Gln Ala Ser Gly Ala Lys Tyr 
        115                 120                 125             


Ile Val Leu Thr Ser Lys His His Glu Gly Phe Thr Leu Trp Gly Ser 
    130                 135                 140                 


Glu Tyr Ser Trp Asn Trp Asn Ala Ile Asp Glu Gly Pro Lys Arg Asp 
145                 150                 155                 160 


Ile Val Lys Glu Leu Glu Val Ala Ile Arg Asn Arg Thr Asp Leu Arg 
                165                 170                 175     


Phe Gly Leu Tyr Tyr Ser Leu Phe Glu Trp Phe His Pro Leu Phe Leu 
            180                 185                 190         


Glu Asp Glu Ser Ser Ser Phe His Lys Arg Gln Phe Pro Val Ser Lys 
        195                 200                 205             


Thr Leu Pro Glu Leu Tyr Glu Leu Val Asn Asn Tyr Gln Pro Glu Val 
    210                 215                 220                 


Leu Trp Ser Asp Gly Asp Gly Gly Ala Pro Asp Gln Tyr Trp Asn Ser 
225                 230                 235                 240 


Thr Gly Phe Leu Ala Trp Leu Tyr Asn Glu Ser Pro Val Arg Gly Thr 
                245                 250                 255     


Val Val Thr Asn Asp Arg Trp Gly Ala Gly Ser Ile Cys Lys His Gly 
            260                 265                 270         


Gly Phe Tyr Thr Cys Ser Asp Arg Tyr Asn Pro Gly His Leu Leu Pro 
        275                 280                 285             


His Lys Trp Glu Asn Cys Met Thr Ile Asp Lys Leu Ser Trp Gly Tyr 
    290                 295                 300                 


Arg Arg Glu Ala Gly Ile Ser Asp Tyr Leu Thr Ile Glu Glu Leu Val 
305                 310                 315                 320 


Lys Gln Leu Val Glu Thr Val Ser Cys Gly Gly Asn Leu Leu Met Asn 
                325                 330                 335     


Ile Gly Pro Thr Leu Asp Gly Thr Ile Ser Val Val Phe Glu Glu Arg 
            340                 345                 350         


Leu Arg Gln Met Gly Ser Trp Leu Lys Val Asn Gly Glu Ala Ile Tyr 
        355                 360                 365             


Glu Thr His Thr Trp Arg Ser Gln Asn Asp Thr Val Thr Pro Asp Val 
    370                 375                 380                 


Trp Tyr Thr Ser Lys Pro Lys Glu Lys Leu Val Tyr Ala Ile Phe Leu 
385                 390                 395                 400 


Lys Trp Pro Thr Ser Gly Gln Leu Phe Leu Gly His Pro Lys Ala Ile 
                405                 410                 415     


Leu Gly Ala Thr Glu Val Lys Leu Leu Gly His Gly Gln Pro Leu Asn 
            420                 425                 430         


Trp Ile Ser Leu Glu Gln Asn Gly Ile Met Val Glu Leu Pro Gln Leu 
        435                 440                 445             


Thr Ile His Gln Met Pro Cys Lys Trp Gly Trp Ala Leu Ala Leu Thr 
    450                 455                 460                 


Asn Val Ile 
465         


<210>  5596
<211>  109
<212>  PRT
<213>  Homo Sapiens

<400>  5596

Gln Leu Val Glu Thr Val Ser Cys Gly Gly Asn Leu Leu Met Asn Ile 
1               5                   10                  15      


Gly Pro Thr Leu Asp Gly Thr Ile Ser Val Val Phe Glu Glu Arg Leu 
            20                  25                  30          


Arg Gln Met Gly Ser Trp Leu Lys Val Asn Gly Glu Ala Ile Tyr Glu 
        35                  40                  45              


Thr His Thr Trp Arg Ser Gln Asn Asp Thr Val Thr Pro Asp Val Trp 
    50                  55                  60                  


Tyr Thr Ser Lys Pro Lys Glu Lys Leu Val Tyr Ala Ile Phe Leu Lys 
65                  70                  75                  80  


Trp Pro Thr Ser Gly Gln Leu Phe Leu Gly His Pro Lys Ala Ile Leu 
                85                  90                  95      


Gly Ala Thr Glu Val Arg Gly Asn Phe Thr Leu Phe Leu 
            100                 105                 


<210>  5597
<211>  69
<212>  PRT
<213>  Homo Sapiens

<400>  5597

Lys Pro Ala His Leu Asn Ala Asn Asp Trp Ala Thr Asn Gly Val Gly 
1               5                   10                  15      


Arg Lys Val Ser His Ser Tyr Gly Tyr Gly Leu Trp Thr Gln Ala Pro 
            20                  25                  30          


Trp Trp Pro Trp Pro Arg Ile Gly Pro Gln Trp Pro Pro Ser Gly Ser 
        35                  40                  45              


Ala Ser Ser Thr Ser Ser Pro Ser Pro Lys Thr Ser Gly Asn Gly Ser 
    50                  55                  60                  


Arg Cys Gly Arg Pro 
65                  


<210>  5598
<211>  69
<212>  PRT
<213>  Homo Sapiens

<400>  5598

Met Glu Leu Arg Pro Trp Leu Leu Trp Val Val Ala Ala Thr Gly Thr 
1               5                   10                  15      


Leu Val Leu Leu Ala Ala Asp Ala Gln Gly Gln Lys Val Phe Thr Asn 
            20                  25                  30          


Thr Trp Ala Val Arg Ile Pro Gly Gly Pro Ala Val Ala Asn Ser Val 
        35                  40                  45              


Ala Arg Lys His Gly Phe Leu Asn Leu Gly Gln Ile Phe Gly Asp Tyr 
    50                  55                  60                  


Tyr His Phe Trp His 
65                  


<210>  5599
<211>  794
<212>  PRT
<213>  Homo Sapiens

<400>  5599

Met Glu Leu Arg Pro Trp Leu Leu Trp Val Val Ala Ala Thr Gly Thr 
1               5                   10                  15      


Leu Val Leu Leu Ala Ala Asp Ala Gln Gly Gln Lys Val Phe Thr Asn 
            20                  25                  30          


Thr Trp Ala Val Arg Ile Pro Gly Gly Pro Ala Val Ala Asn Ser Val 
        35                  40                  45              


Ala Arg Lys His Gly Phe Leu Asn Leu Gly Gln Ile Phe Gly Asp Tyr 
    50                  55                  60                  


Tyr His Phe Trp His Arg Gly Val Thr Lys Arg Ser Leu Ser Pro His 
65                  70                  75                  80  


Arg Pro Arg His Ser Arg Leu Gln Arg Glu Pro Gln Val Gln Trp Leu 
                85                  90                  95      


Glu Gln Gln Val Ala Lys Arg Arg Thr Lys Arg Asp Val Tyr Gln Glu 
            100                 105                 110         


Pro Thr Asp Pro Lys Phe Pro Gln Gln Trp Tyr Leu Ser Gly Val Thr 
        115                 120                 125             


Gln Arg Asp Leu Asn Val Lys Ala Ala Trp Ala Gln Gly Tyr Thr Gly 
    130                 135                 140                 


His Gly Ile Val Val Ser Ile Leu Asp Asp Gly Ile Glu Lys Asn His 
145                 150                 155                 160 


Pro Asp Leu Ala Gly Asn Tyr Asp Pro Gly Ala Ser Phe Asp Val Asn 
                165                 170                 175     


Asp Gln Asp Pro Asp Pro Gln Pro Arg Tyr Thr Gln Met Asn Asp Asn 
            180                 185                 190         


Arg His Gly Thr Arg Cys Ala Gly Glu Val Ala Ala Val Ala Asn Asn 
        195                 200                 205             


Gly Val Cys Gly Val Gly Val Ala Tyr Asn Ala Arg Ile Gly Gly Val 
    210                 215                 220                 


Arg Met Leu Asp Gly Glu Val Thr Asp Ala Val Glu Ala Arg Ser Leu 
225                 230                 235                 240 


Gly Leu Asn Pro Asn His Ile His Ile Tyr Ser Ala Ser Trp Gly Pro 
                245                 250                 255     


Glu Asp Asp Gly Lys Thr Val Asp Gly Pro Ala Arg Leu Ala Glu Glu 
            260                 265                 270         


Ala Phe Phe Arg Gly Val Ser Gln Gly Arg Gly Gly Leu Gly Ser Ile 
        275                 280                 285             


Phe Val Trp Ala Ser Gly Asn Gly Gly Arg Glu His Asp Ser Cys Asn 
    290                 295                 300                 


Cys Asp Gly Tyr Thr Asn Ser Ile Tyr Thr Leu Ser Ile Ser Ser Ala 
305                 310                 315                 320 


Thr Gln Phe Gly Asn Val Pro Trp Tyr Ser Glu Ala Cys Ser Ser Thr 
                325                 330                 335     


Leu Ala Thr Thr Tyr Ser Ser Gly Asn Gln Asn Glu Lys Gln Ile Val 
            340                 345                 350         


Thr Thr Asp Leu Arg Gln Lys Cys Thr Glu Ser His Thr Gly Thr Ser 
        355                 360                 365             


Ala Ser Ala Pro Leu Ala Ala Gly Ile Ile Ala Leu Thr Leu Glu Ala 
    370                 375                 380                 


Asn Lys Asn Leu Thr Trp Arg Asp Met Gln His Leu Val Val Gln Thr 
385                 390                 395                 400 


Ser Lys Pro Ala His Leu Asn Ala Asn Asp Trp Ala Thr Asn Gly Val 
                405                 410                 415     


Gly Arg Lys Val Ser His Ser Tyr Gly Tyr Gly Leu Leu Asp Ala Gly 
            420                 425                 430         


Ala Met Val Ala Leu Ala Gln Asn Trp Thr Thr Val Ala Pro Gln Arg 
        435                 440                 445             


Lys Cys Ile Ile Asp Ile Leu Thr Glu Pro Lys Asp Ile Gly Lys Arg 
    450                 455                 460                 


Leu Glu Val Arg Lys Thr Val Thr Ala Cys Leu Gly Glu Pro Asn His 
465                 470                 475                 480 


Ile Thr Arg Leu Glu His Ala Gln Ala Arg Leu Thr Leu Ser Tyr Asn 
                485                 490                 495     


Arg Arg Gly Asp Leu Ala Ile His Leu Val Ser Pro Met Gly Thr Arg 
            500                 505                 510         


Ser Thr Leu Leu Ala Ala Arg Pro His Asp Tyr Ser Ala Asp Gly Phe 
        515                 520                 525             


Asn Asp Trp Ala Phe Met Thr Thr His Ser Trp Asp Glu Asp Pro Ser 
    530                 535                 540                 


Gly Glu Trp Val Leu Glu Ile Glu Asn Thr Ser Glu Ala Asn Asn Tyr 
545                 550                 555                 560 


Gly Thr Leu Thr Lys Phe Thr Leu Val Leu Tyr Gly Thr Ala Pro Glu 
                565                 570                 575     


Gly Leu Pro Val Pro Pro Glu Ser Ser Gly Cys Lys Thr Leu Thr Ser 
            580                 585                 590         


Ser Gln Ala Cys Val Val Cys Glu Glu Gly Phe Ser Leu His Gln Lys 
        595                 600                 605             


Ser Cys Val Gln His Cys Pro Pro Gly Phe Ala Pro Gln Val Leu Asp 
    610                 615                 620                 


Thr His Tyr Ser Thr Glu Asn Asp Val Glu Thr Ile Arg Ala Ser Val 
625                 630                 635                 640 


Cys Ala Pro Cys His Ala Ser Cys Ala Thr Cys Gln Gly Pro Ala Leu 
                645                 650                 655     


Thr Asp Cys Leu Ser Cys Pro Ser His Ala Ser Leu Asp Pro Val Glu 
            660                 665                 670         


Gln Thr Cys Ser Arg Gln Ser Gln Ser Ser Arg Glu Ser Pro Pro Gln 
        675                 680                 685             


Gln Gln Pro Pro Arg Leu Pro Pro Glu Val Glu Ala Gly Gln Arg Leu 
    690                 695                 700                 


Arg Ala Gly Leu Leu Pro Ser His Leu Pro Glu Val Val Ala Gly Leu 
705                 710                 715                 720 


Ser Cys Ala Phe Ile Val Leu Val Phe Val Thr Val Phe Leu Val Leu 
                725                 730                 735     


Gln Leu Arg Ser Gly Phe Ser Phe Arg Gly Val Lys Val Tyr Thr Met 
            740                 745                 750         


Asp Arg Gly Leu Ile Ser Tyr Lys Gly Leu Pro Pro Glu Ala Trp Gln 
        755                 760                 765             


Glu Glu Cys Pro Ser Asp Ser Glu Glu Asp Glu Gly Arg Gly Glu Arg 
    770                 775                 780                 


Thr Ala Phe Ile Lys Asp Gln Ser Ala Leu 
785                 790                 


<210>  5600
<211>  794
<212>  PRT
<213>  Homo Sapiens

<400>  5600

Met Glu Leu Arg Pro Trp Leu Leu Trp Val Val Ala Ala Thr Gly Thr 
1               5                   10                  15      


Leu Val Leu Leu Ala Ala Asp Ala Gln Gly Gln Lys Val Phe Thr Asn 
            20                  25                  30          


Thr Trp Ala Val Arg Ile Pro Gly Gly Pro Ala Val Ala Asn Ser Val 
        35                  40                  45              


Ala Arg Lys His Gly Phe Leu Asn Leu Gly Gln Ile Phe Gly Asp Tyr 
    50                  55                  60                  


Tyr His Phe Trp His Arg Gly Val Thr Lys Arg Ser Leu Ser Pro His 
65                  70                  75                  80  


Arg Pro Arg His Ser Arg Leu Gln Arg Glu Pro Gln Val Gln Trp Leu 
                85                  90                  95      


Glu Gln Gln Val Ala Lys Arg Arg Thr Lys Arg Asp Val Tyr Gln Glu 
            100                 105                 110         


Pro Thr Asp Pro Lys Phe Pro Gln Gln Trp Tyr Leu Ser Gly Val Thr 
        115                 120                 125             


Gln Arg Asp Leu Asn Val Lys Ala Ala Trp Ala Gln Gly Tyr Thr Gly 
    130                 135                 140                 


His Gly Ile Val Val Ser Ile Leu Asp Asp Gly Ile Glu Lys Asn His 
145                 150                 155                 160 


Pro Asp Leu Ala Gly Asn Tyr Asp Pro Gly Ala Ser Phe Asp Val Asn 
                165                 170                 175     


Asp Gln Asp Pro Asp Pro Gln Pro Arg Tyr Thr Gln Met Asn Asp Asn 
            180                 185                 190         


Arg His Gly Thr Arg Cys Ala Gly Glu Val Ala Ala Val Ala Asn Asn 
        195                 200                 205             


Gly Val Cys Gly Val Gly Val Ala Tyr Asn Ala Arg Ile Gly Gly Val 
    210                 215                 220                 


Arg Met Leu Asp Gly Glu Val Thr Asp Ala Val Glu Ala Arg Ser Leu 
225                 230                 235                 240 


Gly Leu Asn Pro Asn His Ile His Ile Tyr Ser Ala Ser Trp Gly Pro 
                245                 250                 255     


Glu Asp Asp Gly Lys Thr Val Asp Gly Pro Ala Arg Leu Ala Glu Glu 
            260                 265                 270         


Ala Phe Phe Arg Gly Val Ser Gln Gly Arg Gly Gly Leu Gly Ser Ile 
        275                 280                 285             


Phe Val Trp Ala Ser Gly Asn Gly Gly Arg Glu His Asp Ser Cys Asn 
    290                 295                 300                 


Cys Asp Gly Tyr Thr Asn Ser Ile Tyr Thr Leu Ser Ile Ser Ser Ala 
305                 310                 315                 320 


Thr Gln Phe Gly Asn Val Pro Trp Tyr Ser Glu Ala Cys Ser Ser Thr 
                325                 330                 335     


Leu Ala Thr Thr Tyr Ser Ser Gly Asn Gln Asn Glu Lys Gln Ile Val 
            340                 345                 350         


Thr Thr Asp Leu Arg Gln Lys Cys Thr Glu Ser His Thr Gly Thr Ser 
        355                 360                 365             


Ala Ser Ala Pro Leu Ala Ala Gly Ile Ile Ala Leu Thr Leu Glu Ala 
    370                 375                 380                 


Asn Lys Asn Leu Thr Trp Arg Asp Met Gln His Leu Val Val Gln Thr 
385                 390                 395                 400 


Ser Lys Pro Ala His Leu Asn Ala Asn Asp Trp Ala Thr Asn Gly Val 
                405                 410                 415     


Gly Arg Lys Val Ser His Ser Tyr Gly Tyr Gly Leu Leu Asp Ala Gly 
            420                 425                 430         


Ala Met Val Ala Leu Ala Gln Asn Trp Thr Thr Val Ala Pro Gln Arg 
        435                 440                 445             


Lys Cys Ile Ile Asp Ile Leu Thr Glu Pro Lys Asp Ile Gly Lys Arg 
    450                 455                 460                 


Leu Glu Val Arg Lys Thr Val Thr Ala Cys Leu Gly Glu Pro Asn His 
465                 470                 475                 480 


Ile Thr Arg Leu Glu His Ala Gln Ala Arg Leu Thr Leu Ser Tyr Asn 
                485                 490                 495     


Arg Arg Gly Asp Leu Ala Ile His Leu Val Ser Pro Met Gly Thr Arg 
            500                 505                 510         


Ser Thr Leu Leu Ala Ala Arg Pro His Asp Tyr Ser Ala Asp Gly Phe 
        515                 520                 525             


Asn Asp Trp Ala Phe Met Thr Thr His Ser Trp Asp Glu Asp Pro Ser 
    530                 535                 540                 


Gly Glu Trp Val Leu Glu Ile Glu Asn Thr Ser Glu Ala Asn Asn Tyr 
545                 550                 555                 560 


Gly Thr Leu Thr Lys Phe Thr Leu Val Leu Tyr Gly Thr Ala Pro Glu 
                565                 570                 575     


Gly Leu Pro Val Pro Pro Glu Ser Ser Gly Cys Lys Thr Leu Thr Ser 
            580                 585                 590         


Ser Gln Ala Cys Val Val Cys Glu Glu Gly Phe Ser Leu His Gln Lys 
        595                 600                 605             


Ser Cys Val Gln His Cys Pro Pro Gly Phe Ala Pro Gln Val Leu Asp 
    610                 615                 620                 


Thr His Tyr Ser Thr Glu Asn Asp Val Glu Thr Ile Arg Ala Ser Val 
625                 630                 635                 640 


Cys Ala Pro Cys His Ala Ser Cys Ala Thr Cys Gln Gly Pro Ala Leu 
                645                 650                 655     


Thr Asp Cys Leu Ser Cys Pro Ser His Ala Ser Leu Asp Pro Val Glu 
            660                 665                 670         


Gln Thr Cys Ser Arg Gln Ser Gln Ser Ser Arg Glu Ser Pro Pro Gln 
        675                 680                 685             


Gln Gln Pro Pro Arg Leu Pro Pro Glu Val Glu Ala Gly Gln Arg Leu 
    690                 695                 700                 


Arg Ala Gly Leu Leu Pro Ser His Leu Pro Glu Val Val Ala Gly Leu 
705                 710                 715                 720 


Ser Cys Ala Phe Ile Val Leu Val Phe Val Thr Val Phe Leu Val Leu 
                725                 730                 735     


Gln Leu Arg Ser Gly Phe Ser Phe Arg Gly Val Lys Val Tyr Thr Met 
            740                 745                 750         


Asp Arg Gly Leu Ile Ser Tyr Lys Gly Leu Pro Pro Glu Ala Trp Gln 
        755                 760                 765             


Glu Glu Cys Pro Ser Asp Ser Glu Glu Asp Glu Gly Arg Gly Glu Arg 
    770                 775                 780                 


Thr Ala Phe Ile Lys Asp Gln Ser Ala Leu 
785                 790                 


<210>  5601
<211>  794
<212>  PRT
<213>  Homo Sapiens

<400>  5601

Met Glu Leu Arg Pro Trp Leu Leu Trp Val Val Ala Ala Thr Gly Thr 
1               5                   10                  15      


Leu Val Leu Leu Ala Ala Asp Ala Gln Gly Gln Lys Val Phe Thr Asn 
            20                  25                  30          


Thr Trp Ala Val Arg Ile Pro Gly Gly Pro Ala Val Ala Asn Ser Val 
        35                  40                  45              


Ala Arg Lys His Gly Phe Leu Asn Leu Gly Gln Ile Phe Gly Asp Tyr 
    50                  55                  60                  


Tyr His Phe Trp His Arg Gly Val Thr Lys Arg Ser Leu Ser Pro His 
65                  70                  75                  80  


Arg Pro Arg His Ser Arg Leu Gln Arg Glu Pro Gln Val Gln Trp Leu 
                85                  90                  95      


Glu Gln Gln Val Ala Lys Arg Arg Thr Lys Arg Asp Val Tyr Gln Glu 
            100                 105                 110         


Pro Thr Asp Pro Lys Phe Pro Gln Gln Trp Tyr Leu Ser Gly Val Thr 
        115                 120                 125             


Gln Arg Asp Leu Asn Val Lys Ala Ala Trp Ala Gln Gly Tyr Thr Gly 
    130                 135                 140                 


His Gly Ile Val Val Ser Ile Leu Asp Asp Gly Ile Glu Lys Asn His 
145                 150                 155                 160 


Pro Asp Leu Ala Gly Asn Tyr Asp Pro Gly Ala Ser Phe Asp Val Asn 
                165                 170                 175     


Asp Gln Asp Pro Asp Pro Gln Pro Arg Tyr Thr Gln Met Asn Asp Asn 
            180                 185                 190         


Arg His Gly Thr Arg Cys Ala Gly Glu Val Ala Ala Val Ala Asn Asn 
        195                 200                 205             


Gly Val Cys Gly Val Gly Val Ala Tyr Asn Ala Arg Ile Gly Gly Val 
    210                 215                 220                 


Arg Met Leu Asp Gly Glu Val Thr Asp Ala Val Glu Ala Arg Ser Leu 
225                 230                 235                 240 


Gly Leu Asn Pro Asn His Ile His Ile Tyr Ser Ala Ser Trp Gly Pro 
                245                 250                 255     


Glu Asp Asp Gly Lys Thr Val Asp Gly Pro Ala Arg Leu Ala Glu Glu 
            260                 265                 270         


Ala Phe Phe Arg Gly Val Ser Gln Gly Arg Gly Gly Leu Gly Ser Ile 
        275                 280                 285             


Phe Val Trp Ala Ser Gly Asn Gly Gly Arg Glu His Asp Ser Cys Asn 
    290                 295                 300                 


Cys Asp Gly Tyr Thr Asn Ser Ile Tyr Thr Leu Ser Ile Ser Ser Ala 
305                 310                 315                 320 


Thr Gln Phe Gly Asn Val Pro Trp Tyr Ser Glu Ala Cys Ser Ser Thr 
                325                 330                 335     


Leu Ala Thr Thr Tyr Ser Ser Gly Asn Gln Asn Glu Lys Gln Ile Val 
            340                 345                 350         


Thr Thr Asp Leu Arg Gln Lys Cys Thr Glu Ser His Thr Gly Thr Ser 
        355                 360                 365             


Ala Ser Ala Pro Leu Ala Ala Gly Ile Ile Ala Leu Thr Leu Glu Ala 
    370                 375                 380                 


Asn Lys Asn Leu Thr Trp Arg Asp Met Gln His Leu Val Val Gln Thr 
385                 390                 395                 400 


Ser Lys Pro Ala His Leu Asn Ala Asn Asp Trp Ala Thr Asn Gly Val 
                405                 410                 415     


Gly Arg Lys Val Ser His Ser Tyr Gly Tyr Gly Leu Leu Asp Ala Gly 
            420                 425                 430         


Ala Met Val Ala Leu Ala Gln Asn Trp Thr Thr Val Ala Pro Gln Arg 
        435                 440                 445             


Lys Cys Ile Ile Asp Ile Leu Thr Glu Pro Lys Asp Ile Gly Lys Arg 
    450                 455                 460                 


Leu Glu Val Arg Lys Thr Val Thr Ala Cys Leu Gly Glu Pro Asn His 
465                 470                 475                 480 


Ile Thr Arg Leu Glu His Ala Gln Ala Arg Leu Thr Leu Ser Tyr Asn 
                485                 490                 495     


Arg Arg Gly Asp Leu Ala Ile His Leu Val Ser Pro Met Gly Thr Arg 
            500                 505                 510         


Ser Thr Leu Leu Ala Ala Arg Pro His Asp Tyr Ser Ala Asp Gly Phe 
        515                 520                 525             


Asn Asp Trp Ala Phe Met Thr Thr His Ser Trp Asp Glu Asp Pro Ser 
    530                 535                 540                 


Gly Glu Trp Val Leu Glu Ile Glu Asn Thr Ser Glu Ala Asn Asn Tyr 
545                 550                 555                 560 


Gly Thr Leu Thr Lys Phe Thr Leu Val Leu Tyr Gly Thr Ala Pro Glu 
                565                 570                 575     


Gly Leu Pro Val Pro Pro Glu Ser Ser Gly Cys Lys Thr Leu Thr Ser 
            580                 585                 590         


Ser Gln Ala Cys Val Val Cys Glu Glu Gly Phe Ser Leu His Gln Lys 
        595                 600                 605             


Ser Cys Val Gln His Cys Pro Pro Gly Phe Ala Pro Gln Val Leu Asp 
    610                 615                 620                 


Thr His Tyr Ser Thr Glu Asn Asp Val Glu Thr Ile Arg Ala Ser Val 
625                 630                 635                 640 


Cys Ala Pro Cys His Ala Ser Cys Ala Thr Cys Gln Gly Pro Ala Leu 
                645                 650                 655     


Thr Asp Cys Leu Ser Cys Pro Ser His Ala Ser Leu Asp Pro Val Glu 
            660                 665                 670         


Gln Thr Cys Ser Arg Gln Ser Gln Ser Ser Arg Glu Ser Pro Pro Gln 
        675                 680                 685             


Gln Gln Pro Pro Arg Leu Pro Pro Glu Val Glu Ala Gly Gln Arg Leu 
    690                 695                 700                 


Arg Ala Gly Leu Leu Pro Ser His Leu Pro Glu Val Val Ala Gly Leu 
705                 710                 715                 720 


Ser Cys Ala Phe Ile Val Leu Val Phe Val Thr Val Phe Leu Val Leu 
                725                 730                 735     


Gln Leu Arg Ser Gly Phe Ser Phe Arg Gly Val Lys Val Tyr Thr Met 
            740                 745                 750         


Asp Arg Gly Leu Ile Ser Tyr Lys Gly Leu Pro Pro Glu Ala Trp Gln 
        755                 760                 765             


Glu Glu Cys Pro Ser Asp Ser Glu Glu Asp Glu Gly Arg Gly Glu Arg 
    770                 775                 780                 


Thr Ala Phe Ile Lys Asp Gln Ser Ala Leu 
785                 790                 


<210>  5602
<211>  175
<212>  PRT
<213>  Homo Sapiens

<400>  5602

Met Glu Leu Arg Pro Trp Leu Leu Trp Val Val Ala Ala Thr Gly Thr 
1               5                   10                  15      


Leu Val Leu Leu Ala Ala Asp Ala Gln Gly Gln Lys Val Phe Thr Asn 
            20                  25                  30          


Thr Trp Ala Val Arg Ile Pro Gly Gly Pro Ala Val Ala Asn Ser Val 
        35                  40                  45              


Ala Arg Lys His Gly Phe Leu Asn Leu Gly Gln Ile Phe Gly Asp Tyr 
    50                  55                  60                  


Tyr His Phe Trp His Arg Gly Val Thr Lys Arg Ser Leu Ser Pro His 
65                  70                  75                  80  


Arg Pro Arg His Ser Arg Leu Gln Arg Glu Pro Gln Trp Leu Glu Gln 
                85                  90                  95      


Gln Val Ala Lys Arg Arg Thr Lys Arg Asp Val Tyr Gln Glu Pro Thr 
            100                 105                 110         


Asp Pro Lys Phe Pro Gln Gln Trp Tyr Leu Ser Gly Val Thr Gln Arg 
        115                 120                 125             


Asp Leu Asn Val Lys Ala Ala Trp Ala Gln Gly Tyr Thr Gly His Gly 
    130                 135                 140                 


Ile Val Val Ser Ile Leu Asp Asp Gly Ile Glu Lys Asn His Pro Asp 
145                 150                 155                 160 


Leu Ala Gly Asn Tyr Asp Pro Gly Ala Ser Phe Asp Val Asn Asp 
                165                 170                 175 


<210>  5603
<211>  216
<212>  PRT
<213>  Homo Sapiens

<400>  5603

Pro Asn His Ile His Ile Tyr Ser Ala Ser Trp Gly Pro Glu Asp Asp 
1               5                   10                  15      


Gly Lys Thr Val Asp Gly Pro Ala Arg Leu Ala Glu Glu Ala Phe Phe 
            20                  25                  30          


Arg Gly Val Ser Gln Gly Arg Gly Gly Leu Gly Ser Ile Phe Val Trp 
        35                  40                  45              


Ala Ser Gly Asn Gly Gly Arg Glu His Asp Ser Cys Asn Cys Asp Gly 
    50                  55                  60                  


Tyr Thr Asn Ser Ile Tyr Thr Leu Ser Ile Ser Ser Ala Thr Gln Phe 
65                  70                  75                  80  


Gly Asn Val Pro Trp Tyr Ser Glu Ala Cys Ser Ser Thr Leu Ala Thr 
                85                  90                  95      


Thr Tyr Ser Ser Gly Asn Gln Asn Glu Lys Gln Ile Val Thr Thr Asp 
            100                 105                 110         


Leu Arg Gln Lys Cys Thr Glu Ser His Thr Gly Thr Ser Ala Ser Ala 
        115                 120                 125             


Pro Leu Ala Ala Gly Ile Ile Ala Leu Thr Leu Glu Ala Asn Lys Asn 
    130                 135                 140                 


Leu Thr Trp Arg Asp Met Gln His Leu Val Val Gln Thr Ser Lys Pro 
145                 150                 155                 160 


Ala His Leu Asn Ala Asn Asp Trp Ala Thr Asn Gly Val Gly Arg Lys 
                165                 170                 175     


Val Ser His Ser Tyr Gly Tyr Gly Leu Leu Asp Ala Gly Ala Met Val 
            180                 185                 190         


Ala Leu Ala Gln Asn Trp Thr Thr Val Ala Pro Gln Arg Lys Cys Ile 
        195                 200                 205             


Ile Asp Ile Leu Thr Glu Pro Lys 
    210                 215     


<210>  5604
<211>  451
<212>  PRT
<213>  Homo Sapiens

<400>  5604

Met Val Glu Leu Gly Lys Phe Glu Arg Lys Glu Phe Lys Ser Ser Ser 
1               5                   10                  15      


Leu Gln Asp Gly His Thr Lys Met Glu Glu Ala Pro Thr His Leu Asn 
            20                  25                  30          


Ser Phe Leu Lys Lys Glu Gly Leu Thr Phe Asn Arg Lys Arg Lys Trp 
        35                  40                  45              


Glu Leu Asp Ser Tyr Pro Ile Met Leu Trp Trp Ser Pro Leu Thr Gly 
    50                  55                  60                  


Glu Thr Gly Arg Leu Gly Gln Cys Gly Ala Asp Ala Cys Phe Phe Thr 
65                  70                  75                  80  


Ile Asn Arg Thr Tyr Leu His His His Met Thr Lys Ala Phe Leu Phe 
                85                  90                  95      


Tyr Gly Thr Asp Phe Asn Ile Asp Ser Leu Pro Leu Pro Arg Lys Ala 
            100                 105                 110         


His His Asp Trp Ala Val Phe His Glu Glu Ser Pro Lys Asn Asn Tyr 
        115                 120                 125             


Lys Leu Phe His Lys Pro Val Ile Thr Leu Phe Asn Tyr Thr Ala Thr 
    130                 135                 140                 


Phe Ser Arg His Ser His Leu Pro Leu Thr Thr Gln Tyr Leu Glu Ser 
145                 150                 155                 160 


Ile Glu Val Leu Lys Ser Leu Arg Tyr Leu Val Pro Leu Gln Ser Lys 
                165                 170                 175     


Asn Lys Leu Arg Lys Arg Leu Ala Pro Leu Val Tyr Val Gln Ser Asp 
            180                 185                 190         


Cys Asp Pro Pro Ser Asp Arg Asp Ser Tyr Val Arg Glu Leu Met Thr 
        195                 200                 205             


Tyr Ile Glu Val Asp Ser Tyr Gly Glu Cys Leu Arg Asn Lys Asp Leu 
    210                 215                 220                 


Pro Gln Gln Leu Lys Asn Pro Ala Ser Met Asp Ala Asp Gly Phe Tyr 
225                 230                 235                 240 


Arg Ile Ile Ala Gln Tyr Lys Phe Ile Leu Ala Phe Glu Asn Ala Val 
                245                 250                 255     


Cys Asp Asp Tyr Ile Thr Glu Lys Phe Trp Arg Pro Leu Lys Leu Gly 
            260                 265                 270         


Val Val Pro Val Tyr Tyr Gly Ser Pro Ser Ile Thr Asp Trp Leu Pro 
        275                 280                 285             


Ser Asn Lys Ser Ala Ile Leu Val Ser Glu Phe Ser His Pro Arg Glu 
    290                 295                 300                 


Leu Ala Ser Tyr Ile Arg Arg Leu Asp Ser Asp Asp Arg Leu Tyr Glu 
305                 310                 315                 320 


Ala Tyr Val Glu Trp Lys Leu Lys Gly Glu Ile Ser Asn Gln Arg Leu 
                325                 330                 335     


Leu Thr Ala Leu Arg Glu Arg Lys Trp Gly Val Gln Asp Val Asn Gln 
            340                 345                 350         


Asp Asn Tyr Ile Asp Ala Phe Glu Cys Met Val Cys Thr Lys Val Trp 
        355                 360                 365             


Ala Asn Ile Arg Leu Gln Glu Lys Gly Leu Pro Pro Lys Arg Trp Glu 
    370                 375                 380                 


Ala Glu Asp Thr His Leu Ser Cys Pro Glu Pro Thr Val Phe Ala Phe 
385                 390                 395                 400 


Ser Pro Leu Arg Thr Pro Pro Leu Ser Ser Leu Arg Glu Met Trp Ile 
                405                 410                 415     


Ser Ser Phe Glu Gln Ser Lys Lys Glu Ala Gln Ala Leu Arg Trp Leu 
            420                 425                 430         


Val Asp Arg Asn Gln Asn Phe Ser Ser Gln Glu Phe Trp Gly Leu Val 
        435                 440                 445             


Phe Lys Asp 
    450     


<210>  5605
<211>  451
<212>  PRT
<213>  Homo Sapiens

<400>  5605

Met Val Glu Leu Gly Lys Phe Glu Arg Lys Glu Phe Lys Ser Ser Ser 
1               5                   10                  15      


Leu Gln Asp Gly His Thr Lys Met Glu Glu Ala Pro Thr His Leu Asn 
            20                  25                  30          


Ser Phe Leu Lys Lys Glu Gly Leu Thr Phe Asn Arg Lys Arg Lys Trp 
        35                  40                  45              


Glu Leu Asp Ser Tyr Pro Ile Met Leu Trp Trp Ser Pro Leu Thr Gly 
    50                  55                  60                  


Glu Thr Gly Arg Leu Gly Gln Cys Gly Ala Asp Ala Cys Phe Phe Thr 
65                  70                  75                  80  


Ile Asn Arg Thr Tyr Leu His His His Met Thr Lys Ala Phe Leu Phe 
                85                  90                  95      


Tyr Gly Thr Asp Phe Asn Ile Asp Ser Leu Pro Leu Pro Arg Lys Ala 
            100                 105                 110         


His His Asp Trp Ala Val Phe His Glu Glu Ser Pro Lys Asn Asn Tyr 
        115                 120                 125             


Lys Leu Phe His Lys Pro Val Ile Thr Leu Phe Asn Tyr Thr Ala Thr 
    130                 135                 140                 


Phe Ser Arg His Ser His Leu Pro Leu Thr Thr Gln Tyr Leu Glu Ser 
145                 150                 155                 160 


Ile Glu Val Leu Lys Ser Leu Arg Tyr Leu Val Pro Leu Gln Ser Lys 
                165                 170                 175     


Asn Lys Leu Arg Lys Arg Leu Ala Pro Leu Val Tyr Val Gln Ser Asp 
            180                 185                 190         


Cys Asp Pro Pro Ser Asp Arg Asp Ser Tyr Val Arg Glu Leu Met Thr 
        195                 200                 205             


Tyr Ile Glu Val Asp Ser Tyr Gly Glu Cys Leu Arg Asn Lys Asp Leu 
    210                 215                 220                 


Pro Gln Gln Leu Lys Asn Pro Ala Ser Met Asp Ala Asp Gly Phe Tyr 
225                 230                 235                 240 


Arg Ile Ile Ala Gln Tyr Lys Phe Ile Leu Ala Phe Glu Asn Ala Val 
                245                 250                 255     


Cys Asp Asp Tyr Ile Thr Glu Lys Phe Trp Arg Pro Leu Lys Leu Gly 
            260                 265                 270         


Val Val Pro Val Tyr Tyr Gly Ser Pro Ser Ile Thr Asp Trp Leu Pro 
        275                 280                 285             


Ser Asn Lys Ser Ala Ile Leu Val Ser Glu Phe Ser His Pro Arg Glu 
    290                 295                 300                 


Leu Ala Ser Tyr Ile Arg Arg Leu Asp Ser Asp Asp Arg Leu Tyr Glu 
305                 310                 315                 320 


Ala Tyr Val Glu Trp Lys Leu Lys Gly Glu Ile Ser Asn Gln Arg Leu 
                325                 330                 335     


Leu Thr Ala Leu Arg Glu Arg Lys Trp Gly Val Gln Asp Val Asn Gln 
            340                 345                 350         


Asp Asn Tyr Ile Asp Ala Phe Glu Cys Met Val Cys Thr Lys Val Trp 
        355                 360                 365             


Ala Asn Ile Arg Leu Gln Glu Lys Gly Leu Pro Pro Lys Arg Trp Glu 
    370                 375                 380                 


Ala Glu Asp Thr His Leu Ser Cys Pro Glu Pro Thr Val Phe Ala Phe 
385                 390                 395                 400 


Ser Pro Leu Arg Thr Pro Pro Leu Ser Ser Leu Arg Glu Met Trp Ile 
                405                 410                 415     


Ser Ser Phe Glu Gln Ser Lys Lys Glu Ala Gln Ala Leu Arg Trp Leu 
            420                 425                 430         


Val Asp Arg Asn Gln Asn Phe Ser Ser Gln Glu Phe Trp Gly Leu Val 
        435                 440                 445             


Phe Lys Asp 
    450     


<210>  5606
<211>  479
<212>  PRT
<213>  Homo Sapiens

<400>  5606

Met Val Arg Ile Gln Arg Arg Lys Leu Leu Ala Ser Cys Leu Cys Val 
1               5                   10                  15      


Thr Ala Thr Val Phe Leu Leu Val Thr Leu Gln Val Met Val Glu Leu 
            20                  25                  30          


Gly Lys Phe Glu Arg Lys Glu Phe Lys Ser Ser Ser Leu Gln Asp Gly 
        35                  40                  45              


His Thr Lys Met Glu Glu Ala Pro Thr His Leu Asn Ser Phe Leu Lys 
    50                  55                  60                  


Lys Glu Gly Leu Thr Phe Asn Arg Lys Arg Lys Trp Glu Leu Asp Ser 
65                  70                  75                  80  


Tyr Pro Ile Met Leu Trp Trp Ser Pro Leu Thr Gly Glu Thr Gly Arg 
                85                  90                  95      


Leu Gly Gln Cys Gly Ala Asp Ala Cys Phe Phe Thr Ile Asn Arg Thr 
            100                 105                 110         


Tyr Leu His His His Met Thr Lys Ala Phe Leu Phe Tyr Gly Thr Asp 
        115                 120                 125             


Phe Asn Ile Asp Ser Leu Pro Leu Pro Arg Lys Ala His His Asp Trp 
    130                 135                 140                 


Ala Val Phe His Glu Glu Ser Pro Lys Asn Asn Tyr Lys Leu Phe His 
145                 150                 155                 160 


Lys Pro Val Ile Thr Leu Phe Asn Tyr Thr Ala Thr Phe Ser Arg His 
                165                 170                 175     


Ser His Leu Pro Leu Thr Thr Gln Tyr Leu Glu Ser Ile Glu Val Leu 
            180                 185                 190         


Lys Ser Leu Arg Tyr Leu Val Pro Leu Gln Ser Lys Asn Lys Leu Arg 
        195                 200                 205             


Lys Arg Leu Ala Pro Leu Val Tyr Val Gln Ser Asp Cys Asp Pro Pro 
    210                 215                 220                 


Ser Asp Arg Asp Ser Tyr Val Arg Glu Leu Met Thr Tyr Ile Glu Val 
225                 230                 235                 240 


Asp Ser Tyr Gly Glu Cys Leu Arg Asn Lys Asp Leu Pro Gln Gln Leu 
                245                 250                 255     


Lys Asn Pro Ala Ser Met Asp Ala Asp Gly Phe Tyr Arg Ile Ile Ala 
            260                 265                 270         


Gln Tyr Lys Phe Ile Leu Ala Phe Glu Asn Ala Val Cys Asp Asp Tyr 
        275                 280                 285             


Ile Thr Glu Lys Phe Trp Arg Pro Leu Lys Leu Gly Val Val Pro Val 
    290                 295                 300                 


Tyr Tyr Gly Ser Pro Ser Ile Thr Asp Trp Leu Pro Ser Asn Lys Ser 
305                 310                 315                 320 


Ala Ile Leu Val Ser Glu Phe Ser His Pro Arg Glu Leu Ala Ser Tyr 
                325                 330                 335     


Ile Arg Arg Leu Asp Ser Asp Asp Arg Leu Tyr Glu Ala Tyr Val Glu 
            340                 345                 350         


Trp Lys Leu Lys Gly Glu Ile Ser Asn Gln Arg Leu Leu Thr Ala Leu 
        355                 360                 365             


Arg Glu Arg Lys Trp Gly Val Gln Asp Val Asn Gln Asp Asn Tyr Ile 
    370                 375                 380                 


Asp Ala Phe Glu Cys Met Val Cys Thr Lys Val Trp Ala Asn Ile Arg 
385                 390                 395                 400 


Leu Gln Glu Lys Gly Leu Pro Pro Lys Arg Trp Glu Ala Glu Asp Thr 
                405                 410                 415     


His Leu Ser Cys Pro Glu Pro Thr Val Phe Ala Phe Ser Pro Leu Arg 
            420                 425                 430         


Thr Pro Pro Leu Ser Ser Leu Arg Glu Met Trp Ile Ser Ser Phe Glu 
        435                 440                 445             


Gln Ser Lys Lys Glu Ala Gln Ala Leu Arg Trp Leu Val Asp Arg Asn 
    450                 455                 460                 


Gln Asn Phe Ser Ser Gln Glu Phe Trp Gly Leu Val Phe Lys Asp 
465                 470                 475                 


<210>  5607
<211>  492
<212>  PRT
<213>  Homo Sapiens

<400>  5607

Met Ala Ala Gly Pro Ile Arg Val Val Leu Val Leu Leu Gly Val Leu 
1               5                   10                  15      


Ser Val Cys Ala Ala Ser Gly His Gly Ser Val Ala Glu Arg Glu Ala 
            20                  25                  30          


Gly Gly Glu Ala Glu Trp Ala Glu Pro Trp Asp Gly Ala Val Phe Arg 
        35                  40                  45              


Pro Pro Ser Ala Leu Gly Ala Val Gly Val Thr Arg Ser Ser Gly Thr 
    50                  55                  60                  


Pro Arg Pro Gly Arg Glu Glu Ala Gly Asp Leu Pro Val Leu Leu Trp 
65                  70                  75                  80  


Trp Ser Pro Gly Leu Phe Pro His Phe Pro Gly Asp Ser Glu Arg Ile 
                85                  90                  95      


Glu Cys Ala Arg Gly Ala Cys Val Ala Ser Arg Asn Arg Arg Ala Leu 
            100                 105                 110         


Arg Asp Ser Arg Thr Arg Ala Leu Leu Phe Tyr Gly Thr Asp Phe Arg 
        115                 120                 125             


Ala Ser Ala Ala Pro Leu Pro Arg Leu Ala His Gln Ser Trp Ala Leu 
    130                 135                 140                 


Leu His Glu Glu Ser Pro Leu Asn Asn Phe Leu Leu Ser His Gly Pro 
145                 150                 155                 160 


Gly Ile Arg Leu Phe Asn Leu Thr Ser Thr Phe Ser Arg His Ser Asp 
                165                 170                 175     


Tyr Pro Leu Ser Leu Gln Trp Leu Pro Gly Thr Ala Tyr Leu Arg Arg 
            180                 185                 190         


Pro Val Pro Pro Pro Met Glu Arg Ala Glu Trp Arg Arg Arg Gly Tyr 
        195                 200                 205             


Ala Pro Leu Leu Tyr Leu Gln Ser His Cys Asp Val Pro Ala Asp Arg 
    210                 215                 220                 


Asp Arg Tyr Val Arg Glu Leu Met Arg His Ile Pro Val Asp Ser Tyr 
225                 230                 235                 240 


Gly Lys Cys Leu Gln Asn Arg Glu Leu Pro Thr Ala Arg Leu Gln Asp 
                245                 250                 255     


Thr Ala Thr Ala Thr Thr Glu Asp Pro Glu Leu Leu Ala Phe Leu Ser 
            260                 265                 270         


Arg Tyr Lys Phe His Leu Ala Leu Glu Asn Ala Ile Cys Asn Asp Tyr 
        275                 280                 285             


Met Thr Glu Lys Leu Trp Arg Pro Met His Leu Gly Ala Val Pro Val 
    290                 295                 300                 


Tyr Arg Gly Ser Pro Ser Val Arg Asp Trp Met Pro Asn Asn His Ser 
305                 310                 315                 320 


Val Ile Leu Ile Asp Asp Phe Glu Ser Pro Gln Lys Leu Ala Glu Phe 
                325                 330                 335     


Ile Asp Phe Leu Asp Lys Asn Asp Glu Glu Tyr Met Lys Tyr Leu Ala 
            340                 345                 350         


Tyr Lys Gln Pro Gly Gly Ile Thr Asn Gln Phe Leu Leu Asp Ser Leu 
        355                 360                 365             


Lys His Arg Glu Trp Gly Val Asn Asp Pro Leu Leu Pro Asn Tyr Leu 
    370                 375                 380                 


Asn Gly Phe Glu Cys Phe Val Cys Asp Tyr Glu Leu Ala Arg Leu Asp 
385                 390                 395                 400 


Ala Glu Lys Ala His Ala Ala Ser Pro Gly Asp Ser Pro Val Phe Glu 
                405                 410                 415     


Pro His Ile Ala Gln Pro Ser His Met Asp Cys Pro Val Pro Thr Pro 
            420                 425                 430         


Gly Phe Gly Asn Val Glu Glu Ile Pro Glu Asn Asp Ser Trp Lys Glu 
        435                 440                 445             


Met Trp Leu Gln Asp Tyr Trp Gln Gly Leu Asp Gln Gly Glu Ala Leu 
    450                 455                 460                 


Thr Ala Met Ile His Asn Asn Glu Thr Glu Gln Thr Lys Phe Trp Asp 
465                 470                 475                 480 


Tyr Leu His Glu Ile Phe Met Lys Arg Gln His Leu 
                485                 490         


<210>  5608
<211>  476
<212>  PRT
<213>  Homo Sapiens

<400>  5608

Met Ala Ala Gly Pro Ile Arg Val Val Leu Val Leu Leu Gly Val Leu 
1               5                   10                  15      


Ser Val Cys Ala Ala Ser Gly His Gly Ser Val Ala Glu Arg Glu Ala 
            20                  25                  30          


Gly Gly Glu Ala Glu Trp Ala Glu Pro Trp Asp Gly Ala Val Phe Arg 
        35                  40                  45              


Pro Pro Ser Ala Leu Gly Ala Val Gly Val Thr Arg Ser Ser Gly Thr 
    50                  55                  60                  


Pro Arg Pro Gly Arg Glu Glu Ala Gly Asp Leu Pro Val Leu Leu Trp 
65                  70                  75                  80  


Trp Ser Pro Gly Leu Phe Pro His Phe Pro Gly Asp Ser Glu Arg Ile 
                85                  90                  95      


Glu Cys Ala Arg Gly Ala Cys Val Ala Ser Arg Asn Arg Arg Ala Leu 
            100                 105                 110         


Arg Asp Ser Arg Thr Arg Ala Leu Leu Phe Tyr Gly Thr Asp Phe Arg 
        115                 120                 125             


Ala Ser Ala Ala Pro Leu Pro Arg Leu Ala His Gln Ser Trp Ala Leu 
    130                 135                 140                 


Leu His Glu Glu Ser Pro Leu Asn Asn Phe Leu Leu Ser His Gly Pro 
145                 150                 155                 160 


Gly Ile Arg Leu Phe Asn Leu Thr Ser Thr Phe Ser Arg His Ser Asp 
                165                 170                 175     


Tyr Pro Leu Ser Leu Gln Trp Leu Pro Gly Thr Ala Tyr Leu Arg Arg 
            180                 185                 190         


Pro Val Pro Pro Pro Met Glu Arg Ala Glu Trp Arg Arg Arg Gly Tyr 
        195                 200                 205             


Ala Pro Leu Leu Tyr Leu Gln Ser His Cys Asp Val Pro Ala Asp Arg 
    210                 215                 220                 


Asp Arg Tyr Val Arg Glu Leu Met Arg His Ile Pro Val Asp Ser Tyr 
225                 230                 235                 240 


Gly Lys Cys Leu Gln Asn Arg Glu Leu Pro Thr Ala Arg Leu Gln Asp 
                245                 250                 255     


Thr Ala Thr Ala Thr Thr Glu Asp Pro Glu Leu Leu Ala Phe Leu Ser 
            260                 265                 270         


Arg Tyr Lys Phe His Leu Ala Leu Glu Asn Ala Ile Cys Asn Asp Tyr 
        275                 280                 285             


Met Thr Glu Lys Leu Trp Arg Pro Met His Leu Gly Ala Val Pro Val 
    290                 295                 300                 


Tyr Arg Gly Ser Pro Ser Val Arg Asp Trp Met Pro Asn Asn His Ser 
305                 310                 315                 320 


Val Ile Leu Ile Asp Asp Phe Glu Ser Pro Gln Lys Leu Ala Glu Phe 
                325                 330                 335     


Ile Asp Phe Leu Asp Lys Asn Asp Glu Glu Tyr Met Lys Tyr Leu Ala 
            340                 345                 350         


Tyr Lys Gln Pro Gly Gly Ile Thr Asn Gln Phe Leu Leu Asp Ser Leu 
        355                 360                 365             


Lys His Arg Glu Trp Gly Val Asn Asp Pro Leu Leu Pro Asn Tyr Leu 
    370                 375                 380                 


Asn Gly Phe Glu Cys Phe Val Cys Asp Tyr Glu Leu Ala Arg Leu Asp 
385                 390                 395                 400 


Ala Glu Lys Ala His Ala Ala Ser Pro Gly Asp Ser Pro Val Phe Glu 
                405                 410                 415     


Pro His Ile Ala Gln Pro Ser His Met Asp Cys Pro Val Pro Thr Pro 
            420                 425                 430         


Gly Phe Gly Asn Val Glu Glu Ile Pro Glu Asn Asp Ser Ser Leu Val 
        435                 440                 445             


Gln Val Arg Asp His Cys Ile Cys Leu Arg Phe Leu Trp Pro His Ser 
    450                 455                 460                 


Glu Lys Gly Arg Thr His Asn Tyr Ala Ala Val Pro 
465                 470                 475     


<210>  5609
<211>  135
<212>  PRT
<213>  Homo Sapiens

<400>  5609

Met Asn Leu Arg Lys Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp 
1               5                   10                  15      


Glu Thr Thr Tyr Glu Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala 
            20                  25                  30          


Glu Phe Phe Glu Asp Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr 
        35                  40                  45              


Asp Val Ser Phe Gly Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp 
    50                  55                  60                  


Leu Gly Thr Tyr Val Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp 
65                  70                  75                  80  


Leu Ser Ser Pro Ser Ser Gly Pro Lys Arg Tyr Asp Trp Thr Gly Lys 
                85                  90                  95      


Asn Trp Val Tyr Ser His Asp Gly Val Ser Leu His Glu Leu Leu Ala 
            100                 105                 110         


Ala Glu Leu Thr Lys Ala Leu Lys Thr Lys Leu Asp Leu Ser Ser Leu 
        115                 120                 125             


Ala Tyr Ser Gly Lys Asp Ala 
    130                 135 


<210>  5610
<211>  135
<212>  PRT
<213>  Homo Sapiens

<400>  5610

Met Asn Leu Arg Lys Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp 
1               5                   10                  15      


Glu Thr Thr Tyr Glu Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala 
            20                  25                  30          


Glu Phe Phe Glu Asp Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr 
        35                  40                  45              


Asp Val Ser Phe Gly Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp 
    50                  55                  60                  


Leu Gly Thr Tyr Val Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp 
65                  70                  75                  80  


Leu Ser Ser Pro Ser Ser Gly Pro Lys Arg Tyr Asp Trp Thr Gly Lys 
                85                  90                  95      


Asn Trp Val Tyr Ser His Asp Gly Val Ser Leu His Glu Leu Leu Ala 
            100                 105                 110         


Ala Glu Leu Thr Lys Ala Leu Lys Thr Lys Leu Asp Leu Ser Ser Leu 
        115                 120                 125             


Ala Tyr Ser Gly Lys Asp Ala 
    130                 135 


<210>  5611
<211>  171
<212>  PRT
<213>  Homo Sapiens

<400>  5611

Met Trp Thr Leu Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser Pro 
1               5                   10                  15      


Ser Pro Ala Gln Ala Gln Thr Leu Thr Arg Val Pro Arg Pro Ala Glu 
            20                  25                  30          


Leu Ala Pro Leu Cys Gly Arg Arg Gly Leu Arg Thr Asp Ile Asp Ala 
        35                  40                  45              


Thr Cys Thr Pro Arg Arg Ala Ser Ser Asn Gln Arg Gly Leu Asn Gln 
    50                  55                  60                  


Ile Trp Asn Val Lys Lys Gln Ser Val Tyr Leu Met Asn Leu Arg Lys 
65                  70                  75                  80  


Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr Glu 
                85                  90                  95      


Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp 
            100                 105                 110         


Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly 
        115                 120                 125             


Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val 
    130                 135                 140                 


Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser 
145                 150                 155                 160 


Arg Leu Thr Trp Leu Leu Trp Leu Phe His Pro 
                165                 170     


<210>  5612
<211>  196
<212>  PRT
<213>  Homo Sapiens

<400>  5612

Met Trp Thr Leu Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser Pro 
1               5                   10                  15      


Ser Pro Ala Gln Ala Gln Thr Leu Thr Arg Val Pro Arg Pro Ala Glu 
            20                  25                  30          


Leu Ala Pro Leu Cys Gly Arg Arg Gly Leu Arg Thr Asp Ile Asp Ala 
        35                  40                  45              


Thr Cys Thr Pro Arg Arg Ala Ser Ser Asn Gln Arg Gly Leu Asn Gln 
    50                  55                  60                  


Ile Trp Asn Val Lys Lys Gln Ser Val Tyr Leu Met Asn Leu Arg Lys 
65                  70                  75                  80  


Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr Glu 
                85                  90                  95      


Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp 
            100                 105                 110         


Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly 
        115                 120                 125             


Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val 
    130                 135                 140                 


Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser 
145                 150                 155                 160 


Arg Tyr Val Val Asp Leu Ser Val Met Thr Gly Leu Gly Lys Thr Gly 
                165                 170                 175     


Cys Thr Pro Thr Thr Ala Cys Pro Ser Met Ser Cys Trp Pro Gln Ser 
            180                 185                 190         


Ser Leu Lys Pro 
        195     


<210>  5613
<211>  210
<212>  PRT
<213>  Homo Sapiens

<400>  5613

Met Trp Thr Leu Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser Pro 
1               5                   10                  15      


Ser Pro Ala Gln Ala Gln Thr Leu Thr Arg Val Pro Arg Pro Ala Glu 
            20                  25                  30          


Leu Ala Pro Leu Cys Gly Arg Arg Gly Leu Arg Thr Asp Ile Asp Ala 
        35                  40                  45              


Thr Cys Thr Pro Arg Arg Ala Ser Ser Asn Gln Arg Gly Leu Asn Gln 
    50                  55                  60                  


Ile Trp Asn Val Lys Lys Gln Ser Val Tyr Leu Met Asn Leu Arg Lys 
65                  70                  75                  80  


Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr Glu 
                85                  90                  95      


Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp 
            100                 105                 110         


Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly 
        115                 120                 125             


Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val 
    130                 135                 140                 


Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser 
145                 150                 155                 160 


Ser Gly Pro Lys Arg Tyr Asp Trp Thr Gly Lys Asn Trp Val Tyr Ser 
                165                 170                 175     


His Asp Gly Val Ser Leu His Glu Leu Leu Ala Ala Glu Leu Thr Lys 
            180                 185                 190         


Ala Leu Lys Thr Lys Leu Asp Leu Ser Ser Leu Ala Tyr Ser Gly Lys 
        195                 200                 205             


Asp Ala 
    210 


<210>  5614
<211>  210
<212>  PRT
<213>  Homo Sapiens

<400>  5614

Met Trp Thr Leu Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser Pro 
1               5                   10                  15      


Ser Pro Ala Gln Ala Gln Thr Leu Thr Arg Val Pro Arg Pro Ala Glu 
            20                  25                  30          


Leu Ala Pro Leu Cys Gly Arg Arg Gly Leu Arg Thr Asp Ile Asp Ala 
        35                  40                  45              


Thr Cys Thr Pro Arg Arg Ala Ser Ser Asn Gln Arg Gly Leu Asn Gln 
    50                  55                  60                  


Ile Trp Asn Val Lys Lys Gln Ser Val Tyr Leu Met Asn Leu Arg Lys 
65                  70                  75                  80  


Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr Glu 
                85                  90                  95      


Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp 
            100                 105                 110         


Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly 
        115                 120                 125             


Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val 
    130                 135                 140                 


Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser 
145                 150                 155                 160 


Ser Gly Pro Lys Arg Tyr Asp Trp Thr Gly Lys Asn Trp Val Tyr Ser 
                165                 170                 175     


His Asp Gly Val Ser Leu His Glu Leu Leu Ala Ala Glu Leu Thr Lys 
            180                 185                 190         


Ala Leu Lys Thr Lys Leu Asp Leu Ser Ser Leu Ala Tyr Ser Gly Lys 
        195                 200                 205             


Asp Ala 
    210 


<210>  5615
<211>  196
<212>  PRT
<213>  Homo Sapiens

<400>  5615

Met Trp Thr Leu Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser Pro 
1               5                   10                  15      


Ser Pro Ala Gln Ala Gln Thr Leu Thr Arg Val Pro Arg Pro Ala Glu 
            20                  25                  30          


Leu Ala Pro Leu Cys Gly Arg Arg Gly Leu Arg Thr Asp Ile Asp Ala 
        35                  40                  45              


Thr Cys Thr Pro Arg Arg Ala Ser Ser Asn Gln Arg Gly Leu Asn Gln 
    50                  55                  60                  


Ile Trp Asn Val Lys Lys Gln Ser Val Tyr Leu Met Asn Leu Arg Lys 
65                  70                  75                  80  


Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr Glu 
                85                  90                  95      


Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp 
            100                 105                 110         


Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly 
        115                 120                 125             


Val Asn Val Ala Pro Val Ala Val Pro Ser Leu Arg Lys Ser Glu Asp 
    130                 135                 140                 


His Ala Leu Gln Thr Gly His Val Leu Asp Tyr Leu Cys Phe Cys Leu 
145                 150                 155                 160 


Leu Gly Phe Gln Ser Ala Ser Glu Gln Arg Ser Asn Pro Asp Ser Val 
                165                 170                 175     


Val His Arg Met Ala Gly Asp Gly Val Trp Leu Cys Arg Pro Gly Trp 
            180                 185                 190         


Ser Ala Met Ala 
        195     


<210>  5616
<211>  91
<212>  PRT
<213>  Homo Sapiens

<400>  5616

Met Trp Thr Leu Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser Pro 
1               5                   10                  15      


Ser Pro Ala Gln Ala Gln Thr Leu Thr Arg Val Pro Arg Pro Ala Glu 
            20                  25                  30          


Leu Ala Pro Leu Cys Gly Arg Arg Gly Leu Arg Thr Asp Ile Asp Ala 
        35                  40                  45              


Thr Cys Thr Pro Arg Arg Ala Ser Ser Asn Gln Arg Gly Leu Asn Gln 
    50                  55                  60                  


Ile Trp Asn Val Lys Lys Gln Ser Val Tyr Leu Met Asn Leu Arg Lys 
65                  70                  75                  80  


Ser Gly Thr Leu Gly His Pro Gly Val Val Ser 
                85                  90      


<210>  5617
<211>  19
<212>  PRT
<213>  Homo Sapiens

<400>  5617

Met Ala Glu Leu Thr Val Glu Val Arg Gly Ser Asn Gly Ala Phe Tyr 
1               5                   10                  15      


Lys Ala Ile 
            


<210>  5618
<211>  621
<212>  PRT
<213>  Homo Sapiens

<400>  5618

Met Ala Glu Leu Thr Val Glu Val Arg Gly Ser Asn Gly Ala Phe Tyr 
1               5                   10                  15      


Lys Gly Phe Ile Lys Asp Val His Glu Asp Ser Leu Thr Val Val Phe 
            20                  25                  30          


Glu Asn Asn Trp Gln Pro Glu Arg Gln Val Pro Phe Asn Glu Val Arg 
        35                  40                  45              


Leu Pro Pro Pro Pro Asp Ile Lys Lys Glu Ile Ser Glu Gly Asp Glu 
    50                  55                  60                  


Val Glu Val Tyr Ser Arg Ala Asn Asp Gln Glu Pro Cys Gly Trp Trp 
65                  70                  75                  80  


Leu Ala Lys Val Arg Met Met Lys Gly Glu Phe Tyr Val Ile Glu Tyr 
                85                  90                  95      


Ala Ala Cys Asp Ala Thr Tyr Asn Glu Ile Val Thr Phe Glu Arg Leu 
            100                 105                 110         


Arg Pro Val Asn Gln Asn Lys Thr Val Lys Lys Asn Thr Phe Phe Lys 
        115                 120                 125             


Cys Thr Val Asp Val Pro Glu Asp Leu Arg Glu Ala Cys Ala Asn Glu 
    130                 135                 140                 


Asn Ala His Lys Asp Phe Lys Lys Ala Val Gly Ala Cys Arg Ile Phe 
145                 150                 155                 160 


Tyr His Pro Glu Thr Thr Gln Leu Met Ile Leu Ser Ala Ser Glu Ala 
                165                 170                 175     


Thr Val Lys Arg Val Asn Ile Leu Ser Asp Met His Leu Arg Ser Ile 
            180                 185                 190         


Arg Thr Lys Leu Met Leu Met Ser Arg Asn Glu Glu Ala Thr Lys His 
        195                 200                 205             


Leu Glu Cys Thr Lys Gln Leu Ala Ala Ala Phe His Glu Glu Phe Val 
    210                 215                 220                 


Val Arg Glu Asp Leu Met Gly Leu Ala Ile Gly Thr His Gly Ser Asn 
225                 230                 235                 240 


Ile Gln Gln Ala Arg Lys Val Pro Gly Val Thr Ala Ile Glu Leu Asp 
                245                 250                 255     


Glu Asp Thr Gly Thr Phe Arg Ile Tyr Gly Glu Ser Ala Asp Ala Val 
            260                 265                 270         


Lys Lys Ala Arg Gly Phe Leu Glu Phe Val Glu Asp Phe Ile Gln Val 
        275                 280                 285             


Pro Arg Asn Leu Val Gly Lys Val Ile Gly Lys Asn Gly Lys Val Ile 
    290                 295                 300                 


Gln Glu Ile Val Asp Lys Ser Gly Val Val Arg Val Arg Ile Glu Gly 
305                 310                 315                 320 


Asp Asn Glu Asn Lys Leu Pro Arg Glu Asp Gly Met Val Pro Phe Val 
                325                 330                 335     


Phe Val Gly Thr Lys Glu Ser Ile Gly Asn Val Gln Val Leu Leu Glu 
            340                 345                 350         


Tyr His Ile Ala Tyr Leu Lys Glu Val Glu Gln Leu Arg Met Glu Arg 
        355                 360                 365             


Leu Gln Ile Asp Glu Gln Leu Arg Gln Ile Gly Ser Arg Ser Tyr Ser 
    370                 375                 380                 


Gly Arg Gly Arg Gly Arg Arg Gly Pro Asn Tyr Thr Ser Gly Tyr Gly 
385                 390                 395                 400 


Thr Asn Ser Glu Leu Ser Asn Pro Ser Glu Thr Glu Ser Glu Arg Lys 
                405                 410                 415     


Asp Glu Leu Ser Asp Trp Ser Leu Ala Gly Glu Asp Asp Arg Asp Ser 
            420                 425                 430         


Arg His Gln Arg Asp Ser Arg Arg Arg Pro Gly Gly Arg Gly Arg Ser 
        435                 440                 445             


Val Ser Gly Gly Arg Gly Arg Gly Gly Pro Arg Gly Gly Lys Ser Ser 
    450                 455                 460                 


Ile Ser Ser Val Leu Lys Asp Pro Asp Ser Asn Pro Tyr Ser Leu Leu 
465                 470                 475                 480 


Asp Asn Thr Glu Ser Asp Gln Thr Ala Asp Thr Asp Ala Ser Glu Ser 
                485                 490                 495     


His His Ser Thr Asn Arg Arg Arg Arg Ser Arg Arg Arg Arg Thr Asp 
            500                 505                 510         


Glu Asp Ala Val Leu Met Asp Gly Met Thr Glu Ser Asp Thr Ala Ser 
        515                 520                 525             


Val Asn Glu Asn Gly Leu Val Thr Val Ala Asp Tyr Ile Ser Arg Ala 
    530                 535                 540                 


Glu Ser Gln Ser Arg Gln Arg Asn Leu Pro Arg Glu Thr Leu Ala Lys 
545                 550                 555                 560 


Asn Lys Lys Glu Met Ala Lys Asp Val Ile Glu Glu His Gly Pro Ser 
                565                 570                 575     


Glu Lys Ala Ile Asn Gly Pro Thr Ser Ala Ser Gly Asp Asp Ile Ser 
            580                 585                 590         


Lys Leu Gln Arg Thr Pro Gly Glu Glu Lys Ile Asn Thr Leu Lys Glu 
        595                 600                 605             


Glu Asn Thr Gln Glu Ala Ala Val Leu Asn Gly Val Ser 
    610                 615                 620     


<210>  5619
<211>  539
<212>  PRT
<213>  Homo Sapiens

<400>  5619

Met Ala Glu Leu Thr Val Glu Val Arg Gly Ser Asn Gly Ala Phe Tyr 
1               5                   10                  15      


Lys Gly Phe Ile Lys Asp Val His Glu Asp Ser Leu Thr Val Val Phe 
            20                  25                  30          


Glu Asn Asn Trp Gln Pro Glu Arg Gln Val Pro Phe Asn Glu Val Arg 
        35                  40                  45              


Leu Pro Pro Pro Pro Asp Ile Lys Lys Glu Ile Ser Glu Gly Asp Glu 
    50                  55                  60                  


Val Glu Val Tyr Ser Arg Ala Asn Asp Gln Glu Pro Cys Gly Trp Trp 
65                  70                  75                  80  


Leu Ala Lys Val Arg Met Met Lys Gly Glu Phe Tyr Val Ile Glu Tyr 
                85                  90                  95      


Ala Ala Cys Asp Ala Thr Tyr Asn Glu Ile Val Thr Phe Glu Arg Leu 
            100                 105                 110         


Arg Pro Val Asn Gln Asn Lys Thr Val Lys Lys Asn Thr Phe Phe Lys 
        115                 120                 125             


Cys Thr Val Asp Val Pro Glu Asp Leu Arg Glu Ala Cys Ala Asn Glu 
    130                 135                 140                 


Asn Ala His Lys Asp Phe Lys Lys Ala Val Gly Ala Cys Arg Ile Phe 
145                 150                 155                 160 


Tyr His Pro Glu Thr Thr Gln Leu Met Ile Leu Ser Ala Ser Glu Ala 
                165                 170                 175     


Thr Val Lys Arg Val Asn Ile Leu Ser Asp Met His Leu Arg Ser Ile 
            180                 185                 190         


Arg Thr Lys Leu Met Leu Met Ser Arg Asn Glu Glu Ala Thr Lys His 
        195                 200                 205             


Leu Glu Cys Thr Lys Gln Leu Ala Ala Ala Phe His Glu Glu Phe Val 
    210                 215                 220                 


Val Arg Glu Asp Leu Met Gly Leu Ala Ile Gly Thr His Gly Ser Asn 
225                 230                 235                 240 


Ile Gln Gln Ala Arg Lys Val Pro Gly Val Thr Ala Ile Glu Leu Asp 
                245                 250                 255     


Glu Asp Thr Gly Thr Phe Arg Ile Tyr Gly Glu Ser Ala Asp Ala Val 
            260                 265                 270         


Lys Lys Ala Arg Gly Phe Leu Glu Phe Val Glu Asp Phe Ile Gln Val 
        275                 280                 285             


Pro Arg Asn Leu Val Gly Lys Val Ile Gly Lys Asn Gly Lys Val Ile 
    290                 295                 300                 


Gln Glu Ile Val Asp Lys Ser Gly Val Val Arg Val Arg Ile Glu Gly 
305                 310                 315                 320 


Asp Asn Glu Asn Lys Leu Pro Arg Glu Asp Gly Met Val Pro Phe Val 
                325                 330                 335     


Phe Val Gly Thr Lys Glu Ser Ile Gly Asn Val Gln Val Leu Leu Glu 
            340                 345                 350         


Tyr His Ile Ala Tyr Leu Lys Glu Val Glu Gln Leu Arg Met Glu Arg 
        355                 360                 365             


Leu Gln Ile Asp Glu Gln Leu Arg Gln Ile Gly Ser Arg Ser Tyr Ser 
    370                 375                 380                 


Gly Arg Gly Arg Gly Arg Arg Gly Pro Asn Tyr Thr Ser Gly Tyr Gly 
385                 390                 395                 400 


Thr Asn Ser Glu Leu Ser Asn Pro Ser Glu Thr Glu Ser Glu Arg Lys 
                405                 410                 415     


Asp Glu Leu Ser Asp Trp Ser Leu Ala Gly Glu Asp Asp Arg Asp Ser 
            420                 425                 430         


Arg His Gln Arg Asp Ser Arg Arg Arg Pro Gly Gly Arg Gly Arg Ser 
        435                 440                 445             


Val Ser Gly Gly Arg Gly Arg Gly Gly Pro Arg Gly Gly Lys Ser Ser 
    450                 455                 460                 


Ile Ser Ser Val Leu Lys Asp Pro Asp Ser Asn Pro Tyr Ser Leu Leu 
465                 470                 475                 480 


Asp Asn Thr Glu Ser Asp Gln Thr Ala Asp Thr Asp Ala Ser Glu Ser 
                485                 490                 495     


His His Ser Thr Asn Arg Arg Arg Arg Ser Arg Arg Arg Arg Thr Asp 
            500                 505                 510         


Glu Asp Ala Val Leu Met Asp Gly Met Thr Glu Ser Asp Thr Ala Ser 
        515                 520                 525             


Val Asn Glu Asn Gly Leu Gly Lys Arg Cys Asp 
    530                 535                 


<210>  5620
<211>  490
<212>  PRT
<213>  Homo Sapiens

<400>  5620

Met Ala Glu Leu Thr Val Glu Val Arg Gly Ser Asn Gly Ala Phe Tyr 
1               5                   10                  15      


Lys Val Tyr Ser Arg Ala Asn Asp Gln Glu Pro Cys Gly Trp Trp Leu 
            20                  25                  30          


Ala Lys Val Arg Met Met Lys Gly Glu Phe Tyr Val Ile Glu Tyr Ala 
        35                  40                  45              


Ala Cys Asp Ala Thr Tyr Asn Glu Ile Val Thr Phe Glu Arg Leu Arg 
    50                  55                  60                  


Pro Val Asn Gln Asn Lys Thr Val Lys Lys Asn Thr Phe Phe Lys Cys 
65                  70                  75                  80  


Thr Val Asp Val Pro Glu Asp Leu Arg Glu Ala Cys Ala Asn Glu Asn 
                85                  90                  95      


Ala His Lys Asp Phe Lys Lys Ala Val Gly Ala Cys Arg Ile Phe Tyr 
            100                 105                 110         


His Pro Glu Thr Thr Gln Leu Met Ile Leu Ser Ala Ser Glu Ala Thr 
        115                 120                 125             


Val Lys Arg Val Asn Ile Leu Ser Asp Met His Leu Arg Ser Ile Arg 
    130                 135                 140                 


Thr Lys Leu Met Leu Met Ser Arg Asn Glu Glu Ala Thr Lys His Leu 
145                 150                 155                 160 


Glu Cys Thr Lys Gln Leu Ala Ala Ala Phe His Glu Glu Phe Val Val 
                165                 170                 175     


Arg Glu Asp Leu Met Gly Leu Ala Ile Gly Thr His Gly Ser Asn Ile 
            180                 185                 190         


Gln Gln Ala Arg Lys Val Pro Gly Val Thr Ala Ile Glu Leu Asp Glu 
        195                 200                 205             


Asp Thr Gly Thr Phe Arg Ile Tyr Gly Glu Ser Ala Asp Ala Val Lys 
    210                 215                 220                 


Lys Ala Arg Gly Phe Leu Glu Phe Val Glu Asp Phe Ile Gln Val Pro 
225                 230                 235                 240 


Arg Asn Leu Val Gly Lys Val Ile Gly Lys Asn Gly Lys Val Ile Gln 
                245                 250                 255     


Glu Ile Val Asp Lys Ser Gly Val Val Arg Val Arg Ile Glu Gly Asp 
            260                 265                 270         


Asn Glu Asn Lys Leu Pro Arg Glu Asp Gly Met Val Pro Phe Val Phe 
        275                 280                 285             


Val Gly Thr Lys Glu Ser Ile Gly Asn Val Gln Val Leu Leu Glu Tyr 
    290                 295                 300                 


His Ile Ala Tyr Leu Lys Glu Val Glu Gln Leu Arg Met Glu Arg Leu 
305                 310                 315                 320 


Gln Ile Asp Glu Gln Leu Arg Gln Ile Gly Ser Arg Ser Tyr Ser Gly 
                325                 330                 335     


Arg Gly Arg Gly Arg Arg Gly Pro Asn Tyr Thr Ser Gly Tyr Gly Thr 
            340                 345                 350         


Asn Ser Glu Leu Ser Asn Pro Ser Glu Thr Glu Ser Glu Arg Lys Asp 
        355                 360                 365             


Glu Leu Ser Asp Trp Ser Leu Ala Gly Glu Asp Asp Arg Asp Ser Arg 
    370                 375                 380                 


His Gln Arg Asp Ser Arg Arg Arg Pro Gly Gly Arg Gly Arg Ser Val 
385                 390                 395                 400 


Ser Gly Gly Arg Gly Arg Gly Gly Pro Arg Gly Gly Lys Ser Ser Ile 
                405                 410                 415     


Ser Ser Val Leu Lys Asp Pro Asp Ser Asn Pro Tyr Ser Leu Leu Asp 
            420                 425                 430         


Asn Thr Glu Ser Asp Gln Thr Ala Asp Thr Asp Ala Ser Glu Ser His 
        435                 440                 445             


His Ser Thr Asn Arg Arg Arg Arg Ser Arg Arg Arg Arg Thr Asp Glu 
    450                 455                 460                 


Asp Ala Val Leu Met Asp Gly Met Thr Glu Ser Asp Thr Ala Ser Val 
465                 470                 475                 480 


Asn Glu Asn Gly Leu Gly Lys Arg Cys Asp 
                485                 490 


<210>  5621
<211>  75
<212>  PRT
<213>  Homo Sapiens

<400>  5621

Met Met Lys Gly Glu Phe Tyr Val Ile Glu Tyr Ala Ala Cys Asp Ala 
1               5                   10                  15      


Thr Tyr Asn Glu Ile Val Thr Phe Glu Arg Leu Arg Pro Val Asn Gln 
            20                  25                  30          


Asn Lys Thr Val Lys Lys Asn Thr Phe Phe Lys Cys Thr Val Asp Val 
        35                  40                  45              


Pro Glu Asp Leu Arg Glu Ala Cys Ala Asn Glu Asn Ala His Lys Asp 
    50                  55                  60                  


Phe Lys Lys Ala Val Gly Ala Cys Arg Ile Phe 
65                  70                  75  


<210>  5622
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  5622

Met Met Lys Gly Glu Phe Tyr Val Ile Glu Tyr Ala Ala Cys Asp Ala 
1               5                   10                  15      


Thr Tyr Asn Glu Ile Val Thr Phe Glu Arg Leu Arg Pro Val Asn Gln 
            20                  25                  30          


Asn Lys Thr Val Lys Lys Asn Thr Phe Phe Lys Cys Thr Val Asp Val 
        35                  40                  45              


Pro Glu Asp Leu Arg Glu Ala Cys Ala Asn Glu Asn Ala His Lys Asp 
    50                  55                  60                  


Phe Lys Lys Ala Val Gly Ala Cys Arg Ile Phe Tyr His Pro Glu Thr 
65                  70                  75                  80  


Thr Gln Leu Met Ile Leu Ser Ala Ser Glu Ala Thr Val Lys 
                85                  90                  


<210>  5623
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  5623

Met Met Lys Gly Glu Phe Tyr Val Ile Glu Tyr Ala Ala Cys Asp Ala 
1               5                   10                  15      


Thr Tyr Asn Glu Ile Val Thr Phe Glu Arg Leu Arg Pro Val Asn Gln 
            20                  25                  30          


Asn Lys Thr Val Lys Lys Asn Thr Phe Phe Lys Cys Thr Val Asp Val 
        35                  40                  45              


Pro Glu Asp Leu Arg Glu Ala Cys Ala Asn Glu Asn Ala His Lys Asp 
    50                  55                  60                  


Phe Lys Lys Ala Val Gly Ala Cys Arg Ile Phe Tyr His Pro Glu Thr 
65                  70                  75                  80  


Thr Gln Leu Met Ile Leu Ser Ala Ser Glu Ala Thr Val Lys Arg Val 
                85                  90                  95      


Asn Ile Leu Ser Asp Met His Leu Arg Ser Ile Arg Thr Lys Leu Met 
            100                 105                 110         


Leu Met Ser Arg Asn Glu Glu 
        115                 


<210>  5624
<211>  123
<212>  PRT
<213>  Homo Sapiens

<400>  5624

Met Met Lys Gly Glu Phe Tyr Val Ile Glu Tyr Ala Ala Cys Asp Ala 
1               5                   10                  15      


Thr Tyr Asn Glu Ile Val Thr Phe Glu Arg Leu Arg Pro Val Asn Gln 
            20                  25                  30          


Asn Lys Thr Val Lys Lys Asn Thr Phe Phe Lys Cys Thr Val Asp Val 
        35                  40                  45              


Pro Glu Asp Leu Arg Glu Ala Cys Ala Asn Glu Asn Ala His Lys Asp 
    50                  55                  60                  


Phe Lys Lys Ala Val Gly Ala Cys Arg Ile Phe Tyr His Pro Glu Thr 
65                  70                  75                  80  


Thr Gln Leu Met Ile Leu Ser Ala Ser Glu Ala Thr Val Lys Arg Val 
                85                  90                  95      


Asn Ile Leu Ser Asp Met His Leu Arg Ser Ile Arg Thr Lys Leu Met 
            100                 105                 110         


Leu Met Ser Arg Asn Glu Glu Ala Thr Lys His 
        115                 120             


<210>  5625
<211>  536
<212>  PRT
<213>  Homo Sapiens

<400>  5625

Met Met Lys Gly Glu Phe Tyr Val Ile Glu Tyr Ala Ala Cys Asp Ala 
1               5                   10                  15      


Thr Tyr Asn Glu Ile Val Thr Phe Glu Arg Leu Arg Pro Val Asn Gln 
            20                  25                  30          


Asn Lys Thr Val Lys Lys Asn Thr Phe Phe Lys Cys Thr Val Asp Val 
        35                  40                  45              


Pro Glu Asp Leu Arg Glu Ala Cys Ala Asn Glu Asn Ala His Lys Asp 
    50                  55                  60                  


Phe Lys Lys Ala Val Gly Ala Cys Arg Ile Phe Tyr His Pro Glu Thr 
65                  70                  75                  80  


Thr Gln Leu Met Ile Leu Ser Ala Ser Glu Ala Thr Val Lys Arg Val 
                85                  90                  95      


Asn Ile Leu Ser Asp Met His Leu Arg Ser Ile Arg Thr Lys Leu Met 
            100                 105                 110         


Leu Met Ser Arg Asn Glu Glu Ala Thr Lys His Leu Glu Cys Thr Lys 
        115                 120                 125             


Gln Leu Ala Ala Ala Phe His Glu Glu Phe Val Val Arg Glu Asp Leu 
    130                 135                 140                 


Met Gly Leu Ala Ile Gly Thr His Gly Ser Asn Ile Gln Gln Ala Arg 
145                 150                 155                 160 


Lys Val Pro Gly Val Thr Ala Ile Glu Leu Asp Glu Asp Thr Gly Thr 
                165                 170                 175     


Phe Arg Ile Tyr Gly Glu Ser Ala Asp Ala Val Lys Lys Ala Arg Gly 
            180                 185                 190         


Phe Leu Glu Phe Val Glu Asp Phe Ile Gln Val Pro Arg Asn Leu Val 
        195                 200                 205             


Gly Lys Val Ile Gly Lys Asn Gly Lys Val Ile Gln Glu Ile Val Asp 
    210                 215                 220                 


Lys Ser Gly Val Val Arg Val Arg Ile Glu Gly Asp Asn Glu Asn Lys 
225                 230                 235                 240 


Leu Pro Arg Glu Asp Gly Met Val Pro Phe Val Phe Val Gly Thr Lys 
                245                 250                 255     


Glu Ser Ile Gly Asn Val Gln Val Leu Leu Glu Tyr His Ile Ala Tyr 
            260                 265                 270         


Leu Lys Glu Val Glu Gln Leu Arg Met Glu Arg Leu Gln Ile Asp Glu 
        275                 280                 285             


Gln Leu Arg Gln Ile Gly Ser Arg Ser Tyr Ser Gly Arg Gly Arg Gly 
    290                 295                 300                 


Arg Arg Gly Pro Asn Tyr Thr Ser Gly Tyr Gly Thr Asn Ser Glu Leu 
305                 310                 315                 320 


Ser Asn Pro Ser Glu Thr Glu Ser Glu Arg Lys Asp Glu Leu Ser Asp 
                325                 330                 335     


Trp Ser Leu Ala Gly Glu Asp Asp Arg Asp Ser Arg His Gln Arg Asp 
            340                 345                 350         


Ser Arg Arg Arg Pro Gly Gly Arg Gly Arg Ser Val Ser Gly Gly Arg 
        355                 360                 365             


Gly Arg Gly Gly Pro Arg Gly Gly Lys Ser Ser Ile Ser Ser Val Leu 
    370                 375                 380                 


Lys Asp Pro Asp Ser Asn Pro Tyr Ser Leu Leu Asp Asn Thr Glu Ser 
385                 390                 395                 400 


Asp Gln Thr Ala Asp Thr Asp Ala Ser Glu Ser His His Ser Thr Asn 
                405                 410                 415     


Arg Arg Arg Arg Ser Arg Arg Arg Arg Thr Asp Glu Asp Ala Val Leu 
            420                 425                 430         


Met Asp Gly Met Thr Glu Ser Asp Thr Ala Ser Val Asn Glu Asn Gly 
        435                 440                 445             


Leu Val Thr Val Ala Asp Tyr Ile Ser Arg Ala Glu Ser Gln Ser Arg 
    450                 455                 460                 


Gln Arg Asn Leu Pro Arg Glu Thr Leu Ala Lys Asn Lys Lys Glu Met 
465                 470                 475                 480 


Ala Lys Asp Val Ile Glu Glu His Gly Pro Ser Glu Lys Ala Ile Asn 
                485                 490                 495     


Gly Pro Thr Ser Ala Ser Gly Asp Asp Ile Ser Lys Leu Gln Arg Thr 
            500                 505                 510         


Pro Gly Glu Glu Lys Ile Asn Thr Leu Lys Glu Glu Asn Thr Gln Glu 
        515                 520                 525             


Ala Ala Val Leu Asn Gly Val Ser 
    530                 535     


<210>  5626
<211>  454
<212>  PRT
<213>  Homo Sapiens

<400>  5626

Met Met Lys Gly Glu Phe Tyr Val Ile Glu Tyr Ala Ala Cys Asp Ala 
1               5                   10                  15      


Thr Tyr Asn Glu Ile Val Thr Phe Glu Arg Leu Arg Pro Val Asn Gln 
            20                  25                  30          


Asn Lys Thr Val Lys Lys Asn Thr Phe Phe Lys Cys Thr Val Asp Val 
        35                  40                  45              


Pro Glu Asp Leu Arg Glu Ala Cys Ala Asn Glu Asn Ala His Lys Asp 
    50                  55                  60                  


Phe Lys Lys Ala Val Gly Ala Cys Arg Ile Phe Tyr His Pro Glu Thr 
65                  70                  75                  80  


Thr Gln Leu Met Ile Leu Ser Ala Ser Glu Ala Thr Val Lys Arg Val 
                85                  90                  95      


Asn Ile Leu Ser Asp Met His Leu Arg Ser Ile Arg Thr Lys Leu Met 
            100                 105                 110         


Leu Met Ser Arg Asn Glu Glu Ala Thr Lys His Leu Glu Cys Thr Lys 
        115                 120                 125             


Gln Leu Ala Ala Ala Phe His Glu Glu Phe Val Val Arg Glu Asp Leu 
    130                 135                 140                 


Met Gly Leu Ala Ile Gly Thr His Gly Ser Asn Ile Gln Gln Ala Arg 
145                 150                 155                 160 


Lys Val Pro Gly Val Thr Ala Ile Glu Leu Asp Glu Asp Thr Gly Thr 
                165                 170                 175     


Phe Arg Ile Tyr Gly Glu Ser Ala Asp Ala Val Lys Lys Ala Arg Gly 
            180                 185                 190         


Phe Leu Glu Phe Val Glu Asp Phe Ile Gln Val Pro Arg Asn Leu Val 
        195                 200                 205             


Gly Lys Val Ile Gly Lys Asn Gly Lys Val Ile Gln Glu Ile Val Asp 
    210                 215                 220                 


Lys Ser Gly Val Val Arg Val Arg Ile Glu Gly Asp Asn Glu Asn Lys 
225                 230                 235                 240 


Leu Pro Arg Glu Asp Gly Met Val Pro Phe Val Phe Val Gly Thr Lys 
                245                 250                 255     


Glu Ser Ile Gly Asn Val Gln Val Leu Leu Glu Tyr His Ile Ala Tyr 
            260                 265                 270         


Leu Lys Glu Val Glu Gln Leu Arg Met Glu Arg Leu Gln Ile Asp Glu 
        275                 280                 285             


Gln Leu Arg Gln Ile Gly Ser Arg Ser Tyr Ser Gly Arg Gly Arg Gly 
    290                 295                 300                 


Arg Arg Gly Pro Asn Tyr Thr Ser Gly Tyr Gly Thr Asn Ser Glu Leu 
305                 310                 315                 320 


Ser Asn Pro Ser Glu Thr Glu Ser Glu Arg Lys Asp Glu Leu Ser Asp 
                325                 330                 335     


Trp Ser Leu Ala Gly Glu Asp Asp Arg Asp Ser Arg His Gln Arg Asp 
            340                 345                 350         


Ser Arg Arg Arg Pro Gly Gly Arg Gly Arg Ser Val Ser Gly Gly Arg 
        355                 360                 365             


Gly Arg Gly Gly Pro Arg Gly Gly Lys Ser Ser Ile Ser Ser Val Leu 
    370                 375                 380                 


Lys Asp Pro Asp Ser Asn Pro Tyr Ser Leu Leu Asp Asn Thr Glu Ser 
385                 390                 395                 400 


Asp Gln Thr Ala Asp Thr Asp Ala Ser Glu Ser His His Ser Thr Asn 
                405                 410                 415     


Arg Arg Arg Arg Ser Arg Arg Arg Arg Thr Asp Glu Asp Ala Val Leu 
            420                 425                 430         


Met Asp Gly Met Thr Glu Ser Asp Thr Ala Ser Val Asn Glu Asn Gly 
        435                 440                 445             


Leu Gly Lys Arg Cys Asp 
    450                 


<210>  5627
<211>  151
<212>  PRT
<213>  Homo Sapiens

<400>  5627

Met Arg Ala Val Asn Ile Leu Val Tyr Phe Phe Gly Phe Phe Trp Trp 
1               5                   10                  15      


Phe Phe Asn Val Gln Gly Phe Ile Lys Asp Val His Glu Asp Ser Leu 
            20                  25                  30          


Thr Val Val Phe Glu Asn Asn Trp Gln Pro Glu Arg Gln Val Pro Phe 
        35                  40                  45              


Asn Glu Val Arg Leu Pro Pro Pro Pro Asp Ile Lys Lys Glu Ile Ser 
    50                  55                  60                  


Glu Gly Asp Glu Val Glu Val Tyr Ser Arg Ala Asn Asp Gln Glu Pro 
65                  70                  75                  80  


Cys Gly Trp Trp Leu Ala Lys Val Arg Met Met Lys Gly Glu Phe Tyr 
                85                  90                  95      


Val Ile Glu Tyr Ala Ala Cys Asp Ala Thr Tyr Asn Glu Ile Val Thr 
            100                 105                 110         


Phe Glu Arg Leu Arg Pro Val Asn Gln Asn Lys Thr Val Lys Lys Asn 
        115                 120                 125             


Thr Phe Phe Lys Cys Thr Val Asp Val Pro Glu Asp Leu Arg Glu Ala 
    130                 135                 140                 


Cys Ala Asn Glu Asn Ala His 
145                 150     


<210>  5628
<211>  608
<212>  PRT
<213>  Homo Sapiens

<400>  5628

Met Val Thr Glu Gly Phe Ile Lys Asp Val His Glu Asp Ser Leu Thr 
1               5                   10                  15      


Val Val Phe Glu Asn Asn Trp Gln Pro Glu Arg Gln Val Pro Phe Asn 
            20                  25                  30          


Glu Val Arg Leu Pro Pro Pro Pro Asp Ile Lys Lys Glu Ile Ser Glu 
        35                  40                  45              


Gly Asp Glu Val Glu Val Tyr Ser Arg Ala Asn Asp Gln Glu Pro Cys 
    50                  55                  60                  


Gly Trp Trp Leu Ala Lys Val Arg Met Met Lys Gly Glu Phe Tyr Val 
65                  70                  75                  80  


Ile Glu Tyr Ala Ala Cys Asp Ala Thr Tyr Asn Glu Ile Val Thr Phe 
                85                  90                  95      


Glu Arg Leu Arg Pro Val Asn Gln Asn Lys Thr Val Lys Lys Asn Thr 
            100                 105                 110         


Phe Phe Lys Cys Thr Val Asp Val Pro Glu Asp Leu Arg Glu Ala Cys 
        115                 120                 125             


Ala Asn Glu Asn Ala His Lys Asp Phe Lys Lys Ala Val Gly Ala Cys 
    130                 135                 140                 


Arg Ile Phe Tyr His Pro Glu Thr Thr Gln Leu Met Ile Leu Ser Ala 
145                 150                 155                 160 


Ser Glu Ala Thr Val Lys Arg Val Asn Ile Leu Ser Asp Met His Leu 
                165                 170                 175     


Arg Ser Ile Arg Thr Lys Leu Met Leu Met Ser Arg Asn Glu Glu Ala 
            180                 185                 190         


Thr Lys His Leu Glu Cys Thr Lys Gln Leu Ala Ala Ala Phe His Glu 
        195                 200                 205             


Glu Phe Val Val Arg Glu Asp Leu Met Gly Leu Ala Ile Gly Thr His 
    210                 215                 220                 


Gly Ser Asn Ile Gln Gln Ala Arg Lys Val Pro Gly Val Thr Ala Ile 
225                 230                 235                 240 


Glu Leu Asp Glu Asp Thr Gly Thr Phe Arg Ile Tyr Gly Glu Ser Ala 
                245                 250                 255     


Asp Ala Val Lys Lys Ala Arg Gly Phe Leu Glu Phe Val Glu Asp Phe 
            260                 265                 270         


Ile Gln Val Pro Arg Asn Leu Val Gly Lys Val Ile Gly Lys Asn Gly 
        275                 280                 285             


Lys Val Ile Gln Glu Ile Val Asp Lys Ser Gly Val Val Arg Val Arg 
    290                 295                 300                 


Ile Glu Gly Asp Asn Glu Asn Lys Leu Pro Arg Glu Asp Gly Met Val 
305                 310                 315                 320 


Pro Phe Val Phe Val Gly Thr Lys Glu Ser Ile Gly Asn Val Gln Val 
                325                 330                 335     


Leu Leu Glu Tyr His Ile Ala Tyr Leu Lys Glu Val Glu Gln Leu Arg 
            340                 345                 350         


Met Glu Arg Leu Gln Ile Asp Glu Gln Leu Arg Gln Ile Gly Ser Arg 
        355                 360                 365             


Ser Tyr Ser Gly Arg Gly Arg Gly Arg Arg Gly Pro Asn Tyr Thr Ser 
    370                 375                 380                 


Gly Tyr Gly Thr Asn Ser Glu Leu Ser Asn Pro Ser Glu Thr Glu Ser 
385                 390                 395                 400 


Glu Arg Lys Asp Glu Leu Ser Asp Trp Ser Leu Ala Gly Glu Asp Asp 
                405                 410                 415     


Arg Asp Ser Arg His Gln Arg Asp Ser Arg Arg Arg Pro Gly Gly Arg 
            420                 425                 430         


Gly Arg Ser Val Ser Gly Gly Arg Gly Arg Gly Gly Pro Arg Gly Gly 
        435                 440                 445             


Lys Ser Ser Ile Ser Ser Val Leu Lys Asp Pro Asp Ser Asn Pro Tyr 
    450                 455                 460                 


Ser Leu Leu Asp Asn Thr Glu Ser Asp Gln Thr Ala Asp Thr Asp Ala 
465                 470                 475                 480 


Ser Glu Ser His His Ser Thr Asn Arg Arg Arg Arg Ser Arg Arg Arg 
                485                 490                 495     


Arg Thr Asp Glu Asp Ala Val Leu Met Asp Gly Met Thr Glu Ser Asp 
            500                 505                 510         


Thr Ala Ser Val Asn Glu Asn Gly Leu Val Thr Val Ala Asp Tyr Ile 
        515                 520                 525             


Ser Arg Ala Glu Ser Gln Ser Arg Gln Arg Asn Leu Pro Arg Glu Thr 
    530                 535                 540                 


Leu Ala Lys Asn Lys Lys Glu Met Ala Lys Asp Val Ile Glu Glu His 
545                 550                 555                 560 


Gly Pro Ser Glu Lys Ala Ile Asn Gly Pro Thr Ser Ala Ser Gly Asp 
                565                 570                 575     


Asp Ile Ser Lys Leu Gln Arg Thr Pro Gly Glu Glu Lys Ile Asn Thr 
            580                 585                 590         


Leu Lys Glu Glu Asn Thr Gln Glu Ala Ala Val Leu Asn Gly Val Ser 
        595                 600                 605             


<210>  5629
<211>  247
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5629

Xaa Thr Asn Ser Glu Leu Ser Asn Pro Ser Glu Thr Glu Ser Glu Arg 
1               5                   10                  15      


Lys Asp Glu Leu Ser Asp Trp Ser Leu Ala Gly Glu Asp Asp Arg Asp 
            20                  25                  30          


Ser Arg His Gln Arg Asp Ser Arg Arg Arg Pro Gly Gly Arg Gly Arg 
        35                  40                  45              


Ser Val Ser Gly Gly Arg Gly Arg Gly Gly Pro Arg Gly Gly Lys Ser 
    50                  55                  60                  


Ser Ile Ser Ser Val Leu Lys Asp Pro Asp Ser Asn Pro Tyr Ser Leu 
65                  70                  75                  80  


Leu Asp Asn Thr Glu Ser Asp Gln Thr Ala Asp Thr Asp Ala Ser Glu 
                85                  90                  95      


Ser His His Ser Thr Asn Arg Arg Arg Arg Ser Arg Arg Arg Arg Thr 
            100                 105                 110         


Asp Glu Asp Ala Val Leu Met Asp Gly Met Thr Glu Ser Asp Thr Ala 
        115                 120                 125             


Ser Val Asn Glu Asn Gly Leu Asp Asp Ser Glu Lys Lys Pro Gln Arg 
    130                 135                 140                 


Arg Asn Arg Ser Arg Arg Arg Arg Phe Arg Gly Gln Ala Glu Asp Arg 
145                 150                 155                 160 


Gln Pro Val Thr Val Ala Asp Tyr Ile Ser Arg Ala Glu Ser Gln Ser 
                165                 170                 175     


Arg Gln Arg Asn Leu Pro Arg Glu Thr Leu Ala Lys Asn Lys Lys Glu 
            180                 185                 190         


Met Ala Lys Asp Val Ile Glu Glu His Gly Pro Ser Glu Lys Ala Ile 
        195                 200                 205             


Asn Gly Pro Thr Ser Ala Ser Gly Asp Asp Ile Ser Lys Leu Gln Arg 
    210                 215                 220                 


Thr Pro Gly Glu Glu Lys Ile Asn Thr Leu Lys Glu Glu Asn Thr Gln 
225                 230                 235                 240 


Glu Ala Ala Val Leu Asn Gly 
                245         


<210>  5630
<211>  144
<212>  PRT
<213>  Homo Sapiens

<400>  5630

Met Gly Arg Gly Tyr Ser Gly Ala Leu Gln Ala Arg Gly Gly Leu Glu 
1               5                   10                  15      


Glu Pro Leu Glu Arg Gly Leu Arg Gly Pro Ser Phe Thr Gln Ser Pro 
            20                  25                  30          


Leu His Gly Ala Ala Ala Ala Tyr Leu Ser Ala Gln Arg Asp Ala Ser 
        35                  40                  45              


Leu Pro Val Pro Gly Gln Arg Ser Asp Met Gln Lys Val Thr Leu Gly 
    50                  55                  60                  


Leu Leu Val Phe Leu Ala Gly Phe Pro Val Leu Asp Ala Asn Asp Leu 
65                  70                  75                  80  


Glu Asp Lys Asn Ser Pro Phe Tyr Tyr Asp Trp His Ser Leu Gln Val 
                85                  90                  95      


Gly Gly Leu Ile Cys Ala Gly Val Leu Cys Ala Met Gly Ile Ile Ile 
            100                 105                 110         


Val Met Ser Ala Lys Cys Lys Cys Lys Phe Gly Gln Lys Ser Gly His 
        115                 120                 125             


His Pro Gly Glu Thr Pro Pro Leu Ile Thr Pro Gly Ser Ala Gln Ser 
    130                 135                 140                 


<210>  5631
<211>  70
<212>  PRT
<213>  Homo Sapiens

<400>  5631

Met Gln Lys Val Thr Leu Gly Leu Leu Val Phe Leu Ala Gly Phe Pro 
1               5                   10                  15      


Val Leu Asp Ala Asn Asp Leu Glu Asp Lys Asn Ser Pro Phe Tyr Tyr 
            20                  25                  30          


Asp Trp His Ser Leu Gln Val Gly Gly Leu Ile Cys Ala Gly Val Leu 
        35                  40                  45              


Cys Ala Met Gly Ile Ile Ile Val Met Ser Ala Lys Cys Lys Cys Lys 
    50                  55                  60                  


Phe Gly Gln Lys Ser Gly 
65                  70  


<210>  5632
<211>  87
<212>  PRT
<213>  Homo Sapiens

<400>  5632

Met Gln Lys Val Thr Leu Gly Leu Leu Val Phe Leu Ala Gly Phe Pro 
1               5                   10                  15      


Val Leu Asp Ala Asn Asp Leu Glu Asp Lys Asn Ser Pro Phe Tyr Tyr 
            20                  25                  30          


Asp Trp His Ser Leu Gln Val Gly Gly Leu Ile Cys Ala Gly Val Leu 
        35                  40                  45              


Cys Ala Met Gly Ile Ile Ile Val Met Ser Ala Lys Cys Lys Cys Lys 
    50                  55                  60                  


Phe Gly Gln Lys Ser Gly His His Pro Gly Glu Thr Pro Pro Leu Ile 
65                  70                  75                  80  


Thr Pro Gly Ser Ala Gln Ser 
                85          


<210>  5633
<211>  87
<212>  PRT
<213>  Homo Sapiens

<400>  5633

Met Gln Lys Val Thr Leu Gly Leu Leu Val Phe Leu Ala Gly Phe Pro 
1               5                   10                  15      


Val Leu Asp Ala Asn Asp Leu Glu Asp Lys Asn Ser Pro Phe Tyr Tyr 
            20                  25                  30          


Asp Trp His Ser Leu Gln Val Gly Gly Leu Ile Cys Ala Gly Val Leu 
        35                  40                  45              


Cys Ala Met Gly Ile Ile Ile Val Met Ser Ala Lys Cys Lys Cys Lys 
    50                  55                  60                  


Phe Gly Gln Lys Ser Gly His His Pro Gly Glu Thr Pro Pro Leu Ile 
65                  70                  75                  80  


Thr Pro Gly Ser Ala Gln Ser 
                85          


<210>  5634
<211>  87
<212>  PRT
<213>  Homo Sapiens

<400>  5634

Met Gln Lys Val Thr Leu Gly Leu Leu Val Phe Leu Ala Gly Phe Pro 
1               5                   10                  15      


Val Leu Asp Ala Asn Asp Leu Glu Asp Lys Asn Ser Pro Phe Tyr Tyr 
            20                  25                  30          


Asp Trp His Ser Leu Gln Val Gly Gly Leu Ile Cys Ala Gly Val Leu 
        35                  40                  45              


Cys Ala Met Gly Ile Ile Ile Val Met Ser Ala Lys Cys Lys Cys Lys 
    50                  55                  60                  


Phe Gly Gln Lys Ser Gly His His Pro Gly Glu Thr Pro Pro Leu Ile 
65                  70                  75                  80  


Thr Pro Gly Ser Ala Gln Ser 
                85          


<210>  5635
<211>  96
<212>  PRT
<213>  Homo Sapiens

<400>  5635

Met Gln Lys Val Thr Leu Gly Leu Leu Val Phe Leu Ala Gly Phe Pro 
1               5                   10                  15      


Val Leu Asp Ala Asn Asp Leu Glu Asp Lys Asn Ser Pro Phe Tyr Tyr 
            20                  25                  30          


Asp Trp His Ser Leu Gln Val Gly Gly Leu Ile Cys Ala Gly Val Leu 
        35                  40                  45              


Cys Ala Met Gly Ile Ile Ile Val Met Ser Glu Trp Arg Ser Ser Gly 
    50                  55                  60                  


Glu Gln Ala Gly Arg Gly Trp Gly Ser Pro Pro Leu Thr Thr Gln Leu 
65                  70                  75                  80  


Ser Pro Thr Gly Ala Lys Cys Lys Cys Lys Phe Gly Gln Lys Ser Gly 
                85                  90                  95      


<210>  5636
<211>  113
<212>  PRT
<213>  Homo Sapiens

<400>  5636

Met Gln Lys Val Thr Leu Gly Leu Leu Val Phe Leu Ala Gly Phe Pro 
1               5                   10                  15      


Val Leu Asp Ala Asn Asp Leu Glu Asp Lys Asn Ser Pro Phe Tyr Tyr 
            20                  25                  30          


Asp Trp His Ser Leu Gln Val Gly Gly Leu Ile Cys Ala Gly Val Leu 
        35                  40                  45              


Cys Ala Met Gly Ile Ile Ile Val Met Ser Glu Trp Arg Ser Ser Gly 
    50                  55                  60                  


Glu Gln Ala Gly Arg Gly Trp Gly Ser Pro Pro Leu Thr Thr Gln Leu 
65                  70                  75                  80  


Ser Pro Thr Gly Ala Lys Cys Lys Cys Lys Phe Gly Gln Lys Ser Gly 
                85                  90                  95      


His His Pro Gly Glu Thr Pro Pro Leu Ile Thr Pro Gly Ser Ala Gln 
            100                 105                 110         


Ser 
    


<210>  5637
<211>  113
<212>  PRT
<213>  Homo Sapiens

<400>  5637

Met Gln Lys Val Thr Leu Gly Leu Leu Val Phe Leu Ala Gly Phe Pro 
1               5                   10                  15      


Val Leu Asp Ala Asn Asp Leu Glu Asp Lys Asn Ser Pro Phe Tyr Tyr 
            20                  25                  30          


Asp Trp His Ser Leu Gln Val Gly Gly Leu Ile Cys Ala Gly Val Leu 
        35                  40                  45              


Cys Ala Met Gly Ile Ile Ile Val Met Ser Glu Trp Arg Ser Ser Gly 
    50                  55                  60                  


Glu Gln Ala Gly Arg Gly Trp Gly Ser Pro Pro Leu Thr Thr Gln Leu 
65                  70                  75                  80  


Ser Pro Thr Gly Ala Lys Cys Lys Cys Lys Phe Gly Gln Lys Ser Gly 
                85                  90                  95      


His His Pro Gly Glu Thr Pro Pro Leu Ile Thr Pro Gly Ser Ala Gln 
            100                 105                 110         


Ser 
    


<210>  5638
<211>  113
<212>  PRT
<213>  Homo Sapiens

<400>  5638

Met Gln Lys Val Thr Leu Gly Leu Leu Val Phe Leu Ala Gly Phe Pro 
1               5                   10                  15      


Val Leu Asp Ala Asn Asp Leu Glu Asp Lys Asn Ser Pro Phe Tyr Tyr 
            20                  25                  30          


Asp Trp His Ser Leu Gln Val Gly Gly Leu Ile Cys Ala Gly Val Leu 
        35                  40                  45              


Cys Ala Met Gly Ile Ile Ile Val Met Ser Glu Trp Arg Ser Ser Gly 
    50                  55                  60                  


Glu Gln Ala Gly Arg Gly Trp Gly Ser Pro Pro Leu Thr Thr Gln Leu 
65                  70                  75                  80  


Ser Pro Thr Gly Ala Lys Cys Lys Cys Lys Phe Gly Gln Lys Ser Gly 
                85                  90                  95      


His His Pro Gly Glu Thr Pro Pro Leu Ile Thr Pro Gly Ser Ala Gln 
            100                 105                 110         


Ser 
    


<210>  5639
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  5639

Met Gln Lys Val Thr Leu Gly Leu Leu Val Phe Leu Ala Gly Phe Pro 
1               5                   10                  15      


Val Leu Asp Ala Asn Asp Leu Glu Asp Lys Asn Ser Pro Phe Tyr Tyr 
            20                  25                  30          


Gly Ala Pro Tyr Ile Phe Val Lys Arg Met Gly Gly Gln Met Glu Arg 
        35                  40                  45              


Thr Gln Ala Gly Thr Glu Val Pro Ser Thr Phe Leu Leu Asp Trp His 
    50                  55                  60                  


Ser Leu Gln Val Gly Gly Leu Ile Cys Ala Gly Val Leu Cys Ala Met 
65                  70                  75                  80  


Gly Ile Ile Ile Val Met Ser Ala Lys Cys Lys Cys Lys Phe Gly Gln 
                85                  90                  95      


Lys Ser Gly His His Pro Gly Glu Thr Pro Pro Leu Ile Thr Pro Gly 
            100                 105                 110         


Ser Ala Gln Ser 
        115     


<210>  5640
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  5640

Met Gln Lys Val Thr Leu Gly Leu Leu Val Phe Leu Ala Gly Phe Pro 
1               5                   10                  15      


Val Leu Asp Ala Asn Asp Leu Glu Asp Lys Asn Ser Pro Phe Tyr Tyr 
            20                  25                  30          


Gly Ala Pro Tyr Ile Phe Val Lys Arg Met Gly Gly Gln Met Glu Arg 
        35                  40                  45              


Thr Gln Ala Gly Thr Glu Val Pro Ser Thr Phe Leu Leu Asp Trp His 
    50                  55                  60                  


Ser Leu Gln Val Gly Gly Leu Ile Cys Ala Gly Val Leu Cys Ala Met 
65                  70                  75                  80  


Gly Ile Ile Ile Val Met Ser Ala Lys Cys Lys Cys Lys Phe Gly Gln 
                85                  90                  95      


Lys Ser Gly His His Pro Gly Glu Thr Pro Pro Leu Ile Thr Pro Gly 
            100                 105                 110         


Ser Ala Gln Ser 
        115     


<210>  5641
<211>  61
<212>  PRT
<213>  Homo Sapiens

<400>  5641

Met Gln Lys Val Thr Leu Gly Leu Leu Val Phe Leu Ala Gly Phe Pro 
1               5                   10                  15      


Val Leu Asp Ala Asn Asp Leu Glu Asp Lys Asn Ser Pro Phe Tyr Tyr 
            20                  25                  30          


Gly Glu Ser Pro Cys Pro Leu Ser Pro Pro His Asn Pro Thr Tyr Cys 
        35                  40                  45              


Leu Val Pro Arg Val Pro Ile Gln Gly Trp Gly Leu Thr 
    50                  55                  60      


<210>  5642
<211>  61
<212>  PRT
<213>  Homo Sapiens

<400>  5642

Met Gln Lys Val Thr Leu Gly Leu Leu Val Phe Leu Ala Gly Phe Pro 
1               5                   10                  15      


Val Leu Asp Ala Asn Asp Leu Glu Asp Lys Asn Ser Pro Phe Tyr Tyr 
            20                  25                  30          


Gly Glu Ser Pro Cys Pro Leu Ser Pro Pro His Asn Pro Thr Tyr Cys 
        35                  40                  45              


Leu Val Pro Arg Val Pro Ile Gln Gly Trp Gly Leu Thr 
    50                  55                  60      


<210>  5643
<211>  844
<212>  PRT
<213>  Homo Sapiens

<400>  5643

Met Gly Pro Gly Ala Pro Phe Ala Arg Val Gly Trp Pro Leu Pro Leu 
1               5                   10                  15      


Leu Val Val Met Ala Ala Gly Val Ala Pro Val Trp Ala Ser His Ser 
            20                  25                  30          


Pro His Leu Pro Arg Pro His Ser Arg Val Pro Pro His Pro Ser Ser 
        35                  40                  45              


Glu Arg Arg Ala Val Tyr Ile Gly Ala Leu Phe Pro Met Ser Gly Gly 
    50                  55                  60                  


Trp Pro Gly Gly Gln Ala Cys Gln Pro Ala Val Glu Met Ala Leu Glu 
65                  70                  75                  80  


Asp Val Asn Ser Arg Arg Asp Ile Leu Pro Asp Tyr Glu Leu Lys Leu 
                85                  90                  95      


Ile His His Asp Ser Lys Cys Asp Pro Gly Gln Ala Thr Lys Tyr Leu 
            100                 105                 110         


Tyr Glu Leu Leu Tyr Asn Asp Pro Ile Lys Ile Ile Leu Met Pro Gly 
        115                 120                 125             


Cys Ser Ser Val Ser Thr Leu Val Ala Glu Ala Ala Arg Met Trp Asn 
    130                 135                 140                 


Leu Ile Val Leu Ser Tyr Gly Ser Ser Ser Pro Ala Leu Ser Asn Arg 
145                 150                 155                 160 


Gln Arg Phe Pro Thr Phe Phe Arg Thr His Pro Ser Ala Thr Leu His 
                165                 170                 175     


Asn Pro Thr Arg Val Lys Leu Phe Glu Lys Trp Gly Trp Lys Lys Ile 
            180                 185                 190         


Ala Thr Ile Gln Gln Thr Thr Glu Val Phe Thr Ser Thr Leu Asp Asp 
        195                 200                 205             


Leu Glu Glu Arg Val Lys Glu Ala Gly Ile Glu Ile Thr Phe Arg Gln 
    210                 215                 220                 


Ser Phe Phe Ser Asp Pro Ala Val Pro Val Lys Asn Leu Lys Arg Gln 
225                 230                 235                 240 


Asp Ala Arg Ile Ile Val Gly Leu Phe Tyr Glu Thr Glu Ala Arg Lys 
                245                 250                 255     


Val Phe Cys Glu Val Tyr Lys Glu Arg Leu Phe Gly Lys Lys Tyr Val 
            260                 265                 270         


Trp Phe Leu Ile Gly Trp Tyr Ala Asp Asn Trp Phe Lys Ile Tyr Asp 
        275                 280                 285             


Pro Ser Ile Asn Cys Thr Val Asp Glu Met Thr Glu Ala Val Glu Gly 
    290                 295                 300                 


His Ile Thr Thr Glu Ile Val Met Leu Asn Pro Ala Asn Thr Arg Ser 
305                 310                 315                 320 


Ile Ser Asn Met Thr Ser Gln Glu Phe Val Glu Lys Leu Thr Lys Arg 
                325                 330                 335     


Leu Lys Arg His Pro Glu Glu Thr Gly Gly Phe Gln Glu Ala Pro Leu 
            340                 345                 350         


Ala Tyr Asp Ala Ile Trp Ala Leu Ala Leu Ala Leu Asn Lys Thr Ser 
        355                 360                 365             


Gly Gly Gly Gly Arg Ser Gly Val Arg Leu Glu Asp Phe Asn Tyr Asn 
    370                 375                 380                 


Asn Gln Thr Ile Thr Asp Gln Ile Tyr Arg Ala Met Asn Ser Ser Ser 
385                 390                 395                 400 


Phe Glu Gly Val Ser Gly His Val Val Phe Asp Ala Ser Gly Ser Arg 
                405                 410                 415     


Met Ala Trp Thr Leu Ile Glu Gln Leu Gln Gly Gly Ser Tyr Lys Lys 
            420                 425                 430         


Ile Gly Tyr Tyr Asp Ser Thr Lys Asp Asp Leu Ser Trp Ser Lys Thr 
        435                 440                 445             


Asp Lys Trp Ile Gly Gly Ser Pro Pro Ala Asp Gln Thr Leu Val Ile 
    450                 455                 460                 


Lys Thr Phe Arg Phe Leu Ser Gln Lys Leu Phe Ile Ser Val Ser Val 
465                 470                 475                 480 


Leu Ser Ser Leu Gly Ile Val Leu Ala Val Val Cys Leu Ser Phe Asn 
                485                 490                 495     


Ile Tyr Asn Ser His Val Arg Tyr Ile Gln Asn Ser Gln Pro Asn Leu 
            500                 505                 510         


Asn Asn Leu Thr Ala Val Gly Cys Ser Leu Ala Leu Ala Ala Val Phe 
        515                 520                 525             


Pro Leu Gly Leu Asp Gly Tyr His Ile Gly Arg Asn Gln Phe Pro Phe 
    530                 535                 540                 


Val Cys Gln Ala Arg Leu Trp Leu Leu Gly Leu Gly Phe Ser Leu Gly 
545                 550                 555                 560 


Tyr Gly Ser Met Phe Thr Lys Ile Trp Trp Val His Thr Val Phe Thr 
                565                 570                 575     


Lys Lys Glu Glu Lys Lys Glu Trp Arg Lys Thr Leu Glu Pro Trp Lys 
            580                 585                 590         


Leu Tyr Ala Thr Val Gly Leu Leu Val Gly Met Asp Val Leu Thr Leu 
        595                 600                 605             


Ala Ile Trp Gln Ile Val Asp Pro Leu His Arg Thr Ile Glu Thr Phe 
    610                 615                 620                 


Ala Lys Glu Glu Pro Lys Glu Asp Ile Asp Val Ser Ile Leu Pro Gln 
625                 630                 635                 640 


Leu Glu His Cys Ser Ser Arg Lys Met Asn Thr Trp Leu Gly Ile Phe 
                645                 650                 655     


Tyr Gly Tyr Lys Gly Leu Leu Leu Leu Leu Gly Ile Phe Leu Ala Tyr 
            660                 665                 670         


Glu Thr Lys Ser Val Ser Thr Glu Lys Ile Asn Asp His Arg Ala Val 
        675                 680                 685             


Gly Met Ala Ile Tyr Asn Val Ala Val Leu Cys Leu Ile Thr Ala Pro 
    690                 695                 700                 


Val Thr Met Ile Leu Ser Ser Gln Gln Asp Ala Ala Phe Ala Phe Ala 
705                 710                 715                 720 


Ser Leu Ala Ile Val Phe Ser Ser Tyr Ile Thr Leu Val Val Leu Phe 
                725                 730                 735     


Val Pro Lys Met Arg Arg Leu Ile Thr Arg Gly Glu Trp Gln Ser Glu 
            740                 745                 750         


Ala Gln Asp Thr Met Lys Thr Gly Ser Ser Thr Asn Asn Asn Glu Glu 
        755                 760                 765             


Glu Lys Ser Arg Leu Leu Glu Lys Glu Asn Arg Glu Leu Glu Lys Ile 
    770                 775                 780                 


Ile Ala Glu Lys Glu Glu Arg Val Ser Glu Leu Arg His Gln Leu Gln 
785                 790                 795                 800 


Ser Arg Gln Gln Leu Arg Ser Arg Arg His Pro Pro Thr Pro Pro Glu 
                805                 810                 815     


Pro Ser Gly Gly Leu Pro Arg Gly Pro Pro Glu Pro Pro Asp Arg Leu 
            820                 825                 830         


Ser Cys Asp Gly Ser Arg Val His Leu Leu Tyr Lys 
        835                 840                 


<210>  5644
<211>  844
<212>  PRT
<213>  Homo Sapiens

<400>  5644

Met Gly Pro Gly Ala Pro Phe Ala Arg Val Gly Trp Pro Leu Pro Leu 
1               5                   10                  15      


Leu Val Val Met Ala Ala Gly Val Ala Pro Val Trp Ala Ser His Ser 
            20                  25                  30          


Pro His Leu Pro Arg Pro His Ser Arg Val Pro Pro His Pro Ser Ser 
        35                  40                  45              


Glu Arg Arg Ala Val Tyr Ile Gly Ala Leu Phe Pro Met Ser Gly Gly 
    50                  55                  60                  


Trp Pro Gly Gly Gln Ala Cys Gln Pro Ala Val Glu Met Ala Leu Glu 
65                  70                  75                  80  


Asp Val Asn Ser Arg Arg Asp Ile Leu Pro Asp Tyr Glu Leu Lys Leu 
                85                  90                  95      


Ile His His Asp Ser Lys Cys Asp Pro Gly Gln Ala Thr Lys Tyr Leu 
            100                 105                 110         


Tyr Glu Leu Leu Tyr Asn Asp Pro Ile Lys Ile Ile Leu Met Pro Gly 
        115                 120                 125             


Cys Ser Ser Val Ser Thr Leu Val Ala Glu Ala Ala Arg Met Trp Asn 
    130                 135                 140                 


Leu Ile Val Leu Ser Tyr Gly Ser Ser Ser Pro Ala Leu Ser Asn Arg 
145                 150                 155                 160 


Gln Arg Phe Pro Thr Phe Phe Arg Thr His Pro Ser Ala Thr Leu His 
                165                 170                 175     


Asn Pro Thr Arg Val Lys Leu Phe Glu Lys Trp Gly Trp Lys Lys Ile 
            180                 185                 190         


Ala Thr Ile Gln Gln Thr Thr Glu Val Phe Thr Ser Thr Leu Asp Asp 
        195                 200                 205             


Leu Glu Glu Arg Val Lys Glu Ala Gly Ile Glu Ile Thr Phe Arg Gln 
    210                 215                 220                 


Ser Phe Phe Ser Asp Pro Ala Val Pro Val Lys Asn Leu Lys Arg Gln 
225                 230                 235                 240 


Asp Ala Arg Ile Ile Val Gly Leu Phe Tyr Glu Thr Glu Ala Arg Lys 
                245                 250                 255     


Val Phe Cys Glu Val Tyr Lys Glu Arg Leu Phe Gly Lys Lys Tyr Val 
            260                 265                 270         


Trp Phe Leu Ile Gly Trp Tyr Ala Asp Asn Trp Phe Lys Ile Tyr Asp 
        275                 280                 285             


Pro Ser Ile Asn Cys Thr Val Asp Glu Met Thr Glu Ala Val Glu Gly 
    290                 295                 300                 


His Ile Thr Thr Glu Ile Val Met Leu Asn Pro Ala Asn Thr Arg Ser 
305                 310                 315                 320 


Ile Ser Asn Met Thr Ser Gln Glu Phe Val Glu Lys Leu Thr Lys Arg 
                325                 330                 335     


Leu Lys Arg His Pro Glu Glu Thr Gly Gly Phe Gln Glu Ala Pro Leu 
            340                 345                 350         


Ala Tyr Asp Ala Ile Trp Ala Leu Ala Leu Ala Leu Asn Lys Thr Ser 
        355                 360                 365             


Gly Gly Gly Gly Arg Ser Gly Val Arg Leu Glu Asp Phe Asn Tyr Asn 
    370                 375                 380                 


Asn Gln Thr Ile Thr Asp Gln Ile Tyr Arg Ala Met Asn Ser Ser Ser 
385                 390                 395                 400 


Phe Glu Gly Val Ser Gly His Val Val Phe Asp Ala Ser Gly Ser Arg 
                405                 410                 415     


Met Ala Trp Thr Leu Ile Glu Gln Leu Gln Gly Gly Ser Tyr Lys Lys 
            420                 425                 430         


Ile Gly Tyr Tyr Asp Ser Thr Lys Asp Asp Leu Ser Trp Ser Lys Thr 
        435                 440                 445             


Asp Lys Trp Ile Gly Gly Ser Pro Pro Ala Asp Gln Thr Leu Val Ile 
    450                 455                 460                 


Lys Thr Phe Arg Phe Leu Ser Gln Lys Leu Phe Ile Ser Val Ser Val 
465                 470                 475                 480 


Leu Ser Ser Leu Gly Ile Val Leu Ala Val Val Cys Leu Ser Phe Asn 
                485                 490                 495     


Ile Tyr Asn Ser His Val Arg Tyr Ile Gln Asn Ser Gln Pro Asn Leu 
            500                 505                 510         


Asn Asn Leu Thr Ala Val Gly Cys Ser Leu Ala Leu Ala Ala Val Phe 
        515                 520                 525             


Pro Leu Gly Leu Asp Gly Tyr His Ile Gly Arg Asn Gln Phe Pro Phe 
    530                 535                 540                 


Val Cys Gln Ala Arg Leu Trp Leu Leu Gly Leu Gly Phe Ser Leu Gly 
545                 550                 555                 560 


Tyr Gly Ser Met Phe Thr Lys Ile Trp Trp Val His Thr Val Phe Thr 
                565                 570                 575     


Lys Lys Glu Glu Lys Lys Glu Trp Arg Lys Thr Leu Glu Pro Trp Lys 
            580                 585                 590         


Leu Tyr Ala Thr Val Gly Leu Leu Val Gly Met Asp Val Leu Thr Leu 
        595                 600                 605             


Ala Ile Trp Gln Ile Val Asp Pro Leu His Arg Thr Ile Glu Thr Phe 
    610                 615                 620                 


Ala Lys Glu Glu Pro Lys Glu Asp Ile Asp Val Ser Ile Leu Pro Gln 
625                 630                 635                 640 


Leu Glu His Cys Ser Ser Arg Lys Met Asn Thr Trp Leu Gly Ile Phe 
                645                 650                 655     


Tyr Gly Tyr Lys Gly Leu Leu Leu Leu Leu Gly Ile Phe Leu Ala Tyr 
            660                 665                 670         


Glu Thr Lys Ser Val Ser Thr Glu Lys Ile Asn Asp His Arg Ala Val 
        675                 680                 685             


Gly Met Ala Ile Tyr Asn Val Ala Val Leu Cys Leu Ile Thr Ala Pro 
    690                 695                 700                 


Val Thr Met Ile Leu Ser Ser Gln Gln Asp Ala Ala Phe Ala Phe Ala 
705                 710                 715                 720 


Ser Leu Ala Ile Val Phe Ser Ser Tyr Ile Thr Leu Val Val Leu Phe 
                725                 730                 735     


Val Pro Lys Met Arg Arg Leu Ile Thr Arg Gly Glu Trp Gln Ser Glu 
            740                 745                 750         


Ala Gln Asp Thr Met Lys Thr Gly Ser Ser Thr Asn Asn Asn Glu Glu 
        755                 760                 765             


Glu Lys Ser Arg Leu Leu Glu Lys Glu Asn Arg Glu Leu Glu Lys Ile 
    770                 775                 780                 


Ile Ala Glu Lys Glu Glu Arg Val Ser Glu Leu Arg His Gln Leu Gln 
785                 790                 795                 800 


Ser Arg Gln Gln Leu Arg Ser Arg Arg His Pro Pro Thr Pro Pro Glu 
                805                 810                 815     


Pro Ser Gly Gly Leu Pro Arg Gly Pro Pro Glu Pro Pro Asp Arg Leu 
            820                 825                 830         


Ser Cys Asp Gly Ser Arg Val His Leu Leu Tyr Lys 
        835                 840                 


<210>  5645
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  5645

Met Leu Leu Leu Leu Leu Leu Ala Pro Leu Phe Leu Arg Pro Pro Gly 
1               5                   10                  15      


Ala Gly Gly Ala Gln Thr Pro Asn Ala Thr Ser Glu Gly Cys Gln Ile 
            20                  25                  30          


Ile His Pro Pro Trp Glu Gly Gly Ile Arg Tyr Arg Gly Leu Thr Arg 
        35                  40                  45              


Asp Gln Val Lys Ala Ile Asn Phe Leu Pro Val Asp Tyr Glu Ile Glu 
    50                  55                  60                  


Tyr Val Cys Arg Gly Glu Arg Glu Val Val Gly Pro Lys Val Arg Lys 
65                  70                  75                  80  


Cys Leu Ala Asn Gly Ser Trp Thr Asp Met Asp Thr Pro Ser Arg Cys 
                85                  90                  95      


Gly Thr Leu Pro Ser Glu Thr Gln Ala Ser Ala Leu Pro Gly Leu Gln 
            100                 105                 110         


His Gly Gln Val Trp Glu Gly Ala Gly Asp Gln Ala Arg Glu Ala Gly 
        115                 120                 125             


Arg Gln Trp 
    130     


<210>  5646
<211>  97
<212>  PRT
<213>  Homo Sapiens

<400>  5646

Met Leu Leu Leu Leu Leu Leu Ala Pro Leu Phe Leu Arg Pro Pro Gly 
1               5                   10                  15      


Ala Gly Gly Ala Gln Thr Pro Asn Ala Thr Ser Glu Gly Cys Gln Ile 
            20                  25                  30          


Ile His Pro Pro Trp Glu Gly Gly Ile Arg Tyr Arg Gly Leu Thr Arg 
        35                  40                  45              


Asp Gln Val Lys Ala Ile Asn Phe Leu Pro Val Asp Tyr Glu Ile Glu 
    50                  55                  60                  


Tyr Val Cys Arg Gly Glu Arg Glu Val Val Gly Pro Lys Val Arg Lys 
65                  70                  75                  80  


Cys Leu Ala Asn Gly Ser Trp Thr Asp Met Asp Thr Pro Ser Arg Cys 
                85                  90                  95      


Val 
    


<210>  5647
<211>  899
<212>  PRT
<213>  Homo Sapiens

<400>  5647

Met Leu Leu Leu Leu Leu Leu Ala Pro Leu Phe Leu Arg Pro Pro Gly 
1               5                   10                  15      


Ala Gly Gly Ala Gln Thr Pro Asn Ala Thr Ser Glu Gly Cys Gln Ile 
            20                  25                  30          


Ile His Pro Pro Trp Glu Gly Gly Ile Arg Tyr Arg Gly Leu Thr Arg 
        35                  40                  45              


Asp Gln Val Lys Ala Ile Asn Phe Leu Pro Val Asp Tyr Glu Ile Glu 
    50                  55                  60                  


Tyr Val Cys Arg Gly Glu Arg Glu Val Val Gly Pro Lys Val Arg Lys 
65                  70                  75                  80  


Cys Leu Ala Asn Gly Ser Trp Thr Asp Met Asp Thr Pro Ser Arg Cys 
                85                  90                  95      


Val Asn Arg Thr Pro His Ser Glu Arg Arg Ala Val Tyr Ile Gly Ala 
            100                 105                 110         


Leu Phe Pro Met Ser Gly Gly Trp Pro Gly Gly Gln Ala Cys Gln Pro 
        115                 120                 125             


Ala Val Glu Met Ala Leu Glu Asp Val Asn Ser Arg Arg Asp Ile Leu 
    130                 135                 140                 


Pro Asp Tyr Glu Leu Lys Leu Ile His His Asp Ser Lys Cys Asp Pro 
145                 150                 155                 160 


Gly Gln Ala Thr Lys Tyr Leu Tyr Glu Leu Leu Tyr Asn Asp Pro Ile 
                165                 170                 175     


Lys Ile Ile Leu Met Pro Gly Cys Ser Ser Val Ser Thr Leu Val Ala 
            180                 185                 190         


Glu Ala Ala Arg Met Trp Asn Leu Ile Val Leu Ser Tyr Gly Ser Ser 
        195                 200                 205             


Ser Pro Ala Leu Ser Asn Arg Gln Arg Phe Pro Thr Phe Phe Arg Thr 
    210                 215                 220                 


His Pro Ser Ala Thr Leu His Asn Pro Thr Arg Val Lys Leu Phe Glu 
225                 230                 235                 240 


Lys Trp Gly Trp Lys Lys Ile Ala Thr Ile Gln Gln Thr Thr Glu Val 
                245                 250                 255     


Phe Thr Ser Thr Leu Asp Asp Leu Glu Glu Arg Val Lys Glu Ala Gly 
            260                 265                 270         


Ile Glu Ile Thr Phe Arg Gln Ser Phe Phe Ser Asp Pro Ala Val Pro 
        275                 280                 285             


Val Lys Asn Leu Lys Arg Gln Asp Ala Arg Ile Ile Val Gly Leu Phe 
    290                 295                 300                 


Tyr Glu Thr Glu Ala Arg Lys Val Phe Cys Glu Val Tyr Lys Glu Arg 
305                 310                 315                 320 


Leu Phe Gly Lys Lys Tyr Val Trp Phe Leu Ile Gly Trp Tyr Ala Asp 
                325                 330                 335     


Asn Trp Phe Lys Ile Tyr Asp Pro Ser Ile Asn Cys Thr Val Asp Glu 
            340                 345                 350         


Met Thr Glu Ala Val Glu Gly His Ile Thr Thr Glu Ile Val Met Leu 
        355                 360                 365             


Asn Pro Ala Asn Thr Arg Ser Ile Ser Asn Met Thr Ser Gln Glu Phe 
    370                 375                 380                 


Val Glu Lys Leu Thr Lys Arg Leu Lys Arg His Pro Glu Glu Thr Gly 
385                 390                 395                 400 


Gly Phe Gln Glu Ala Pro Leu Ala Tyr Asp Ala Ile Trp Ala Leu Ala 
                405                 410                 415     


Leu Ala Leu Asn Lys Thr Ser Gly Gly Gly Gly Arg Ser Gly Val Arg 
            420                 425                 430         


Leu Glu Asp Phe Asn Tyr Asn Asn Gln Thr Ile Thr Asp Gln Ile Tyr 
        435                 440                 445             


Arg Ala Met Asn Ser Ser Ser Phe Glu Gly Val Ser Gly His Val Val 
    450                 455                 460                 


Phe Asp Ala Ser Gly Ser Arg Met Ala Trp Thr Leu Ile Glu Gln Leu 
465                 470                 475                 480 


Gln Gly Gly Ser Tyr Lys Lys Ile Gly Tyr Tyr Asp Ser Thr Lys Asp 
                485                 490                 495     


Asp Leu Ser Trp Ser Lys Thr Asp Lys Trp Ile Gly Gly Ser Pro Pro 
            500                 505                 510         


Ala Asp Gln Thr Leu Val Ile Lys Thr Phe Arg Phe Leu Ser Gln Lys 
        515                 520                 525             


Leu Phe Ile Ser Val Ser Val Leu Ser Ser Leu Gly Ile Val Leu Ala 
    530                 535                 540                 


Val Val Cys Leu Ser Phe Asn Ile Tyr Asn Ser His Val Arg Tyr Ile 
545                 550                 555                 560 


Gln Asn Ser Gln Pro Asn Leu Asn Asn Leu Thr Ala Val Gly Cys Ser 
                565                 570                 575     


Leu Ala Leu Ala Ala Val Phe Pro Leu Gly Leu Asp Gly Tyr His Ile 
            580                 585                 590         


Gly Arg Asn Gln Phe Pro Phe Val Cys Gln Ala Arg Leu Trp Leu Leu 
        595                 600                 605             


Gly Leu Gly Phe Ser Leu Gly Tyr Gly Ser Met Phe Thr Lys Ile Trp 
    610                 615                 620                 


Trp Val His Thr Val Phe Thr Lys Lys Glu Glu Lys Lys Glu Trp Arg 
625                 630                 635                 640 


Lys Thr Leu Glu Pro Trp Lys Leu Tyr Ala Thr Val Gly Leu Leu Val 
                645                 650                 655     


Gly Met Asp Val Leu Thr Leu Ala Ile Trp Gln Ile Val Asp Pro Leu 
            660                 665                 670         


His Arg Thr Ile Glu Thr Phe Ala Lys Glu Glu Pro Lys Glu Asp Ile 
        675                 680                 685             


Asp Val Ser Ile Leu Pro Gln Leu Glu His Cys Ser Ser Arg Lys Met 
    690                 695                 700                 


Asn Thr Trp Leu Gly Ile Phe Tyr Gly Tyr Lys Gly Leu Leu Leu Leu 
705                 710                 715                 720 


Leu Gly Ile Phe Leu Ala Tyr Glu Thr Lys Ser Val Ser Thr Glu Lys 
                725                 730                 735     


Ile Asn Asp His Arg Ala Val Gly Met Ala Ile Tyr Asn Val Ala Val 
            740                 745                 750         


Leu Cys Leu Ile Thr Ala Pro Val Thr Met Ile Leu Ser Ser Gln Gln 
        755                 760                 765             


Asp Ala Ala Phe Ala Phe Ala Ser Leu Ala Ile Val Phe Ser Ser Tyr 
    770                 775                 780                 


Ile Thr Leu Val Val Leu Phe Val Pro Lys Met Arg Arg Leu Ile Thr 
785                 790                 795                 800 


Arg Gly Glu Trp Gln Ser Glu Ala Gln Asp Thr Met Lys Thr Gly Ser 
                805                 810                 815     


Ser Thr Asn Asn Asn Glu Glu Glu Lys Ser Arg Leu Leu Glu Lys Glu 
            820                 825                 830         


Asn Arg Glu Leu Glu Lys Ile Ile Ala Glu Lys Glu Glu Arg Val Ser 
        835                 840                 845             


Glu Leu Arg His Gln Leu Gln Ser Arg Gln Gln Leu Arg Ser Arg Arg 
    850                 855                 860                 


His Pro Pro Thr Pro Pro Glu Pro Ser Gly Gly Leu Pro Arg Gly Pro 
865                 870                 875                 880 


Pro Glu Pro Pro Asp Arg Leu Ser Cys Asp Gly Ser Arg Val His Leu 
                885                 890                 895     


Leu Tyr Lys 
            


<210>  5648
<211>  137
<212>  PRT
<213>  Homo Sapiens

<400>  5648

Met Leu Leu Leu Leu Leu Leu Ala Pro Leu Phe Leu Arg Pro Pro Gly 
1               5                   10                  15      


Ala Gly Gly Ala Gln Thr Pro Asn Ala Thr Ser Glu Gly Cys Gln Ile 
            20                  25                  30          


Ile His Pro Pro Trp Glu Gly Gly Ile Arg Tyr Arg Gly Leu Thr Arg 
        35                  40                  45              


Asp Gln Val Lys Ala Ile Asn Phe Leu Pro Val Asp Tyr Glu Ile Glu 
    50                  55                  60                  


Tyr Val Cys Arg Gly Glu Arg Glu Val Val Gly Pro Lys Val Arg Lys 
65                  70                  75                  80  


Cys Leu Ala Asn Gly Ser Trp Thr Asp Met Asp Thr Pro Ser Arg Cys 
                85                  90                  95      


Val Arg Ile Cys Ser Lys Ser Tyr Leu Thr Leu Glu Asn Gly Lys Val 
            100                 105                 110         


Phe Leu Thr Gly Gly Asp Leu Pro Ala Leu Asp Gly Ala Arg Val Asp 
        115                 120                 125             


Phe Arg Cys Asp Pro Asp Phe His Leu 
    130                 135         


<210>  5649
<211>  156
<212>  PRT
<213>  Homo Sapiens

<400>  5649

Met Leu Leu Leu Leu Leu Leu Ala Pro Leu Phe Leu Arg Pro Pro Gly 
1               5                   10                  15      


Ala Gly Gly Ala Gln Thr Pro Asn Ala Thr Ser Glu Gly Cys Gln Ile 
            20                  25                  30          


Ile His Pro Pro Trp Glu Gly Gly Ile Arg Tyr Arg Gly Leu Thr Arg 
        35                  40                  45              


Asp Gln Val Lys Ala Ile Asn Phe Leu Pro Val Asp Tyr Glu Ile Glu 
    50                  55                  60                  


Tyr Val Cys Arg Gly Glu Arg Glu Val Val Gly Pro Lys Val Arg Lys 
65                  70                  75                  80  


Cys Leu Ala Asn Gly Ser Trp Thr Asp Met Asp Thr Pro Ser Arg Cys 
                85                  90                  95      


Val Arg Ile Cys Ser Lys Ser Tyr Leu Thr Leu Glu Asn Gly Lys Val 
            100                 105                 110         


Phe Leu Thr Gly Gly Asp Leu Pro Ala Leu Asp Gly Ala Arg Val Asp 
        115                 120                 125             


Phe Arg Cys Asp Pro Asp Phe His Leu Val Gly Ser Ser Arg Ser Ile 
    130                 135                 140                 


Cys Ser Gln Gly Gln Trp Ser Thr Pro Lys Pro His 
145                 150                 155     


<210>  5650
<211>  193
<212>  PRT
<213>  Homo Sapiens

<400>  5650

Met Leu Leu Leu Leu Leu Leu Ala Pro Leu Phe Leu Arg Pro Pro Gly 
1               5                   10                  15      


Ala Gly Gly Ala Gln Thr Pro Asn Ala Thr Ser Glu Gly Cys Gln Ile 
            20                  25                  30          


Ile His Pro Pro Trp Glu Gly Gly Ile Arg Tyr Arg Gly Leu Thr Arg 
        35                  40                  45              


Asp Gln Val Lys Ala Ile Asn Phe Leu Pro Val Asp Tyr Glu Ile Glu 
    50                  55                  60                  


Tyr Val Cys Arg Gly Glu Arg Glu Val Val Gly Pro Lys Val Arg Lys 
65                  70                  75                  80  


Cys Leu Ala Asn Gly Ser Trp Thr Asp Met Asp Thr Pro Ser Arg Cys 
                85                  90                  95      


Val Arg Ile Cys Ser Lys Ser Tyr Leu Thr Leu Glu Asn Gly Lys Val 
            100                 105                 110         


Phe Leu Thr Gly Gly Asp Leu Pro Ala Leu Asp Gly Ala Arg Val Asp 
        115                 120                 125             


Phe Arg Cys Asp Pro Asp Phe His Leu Val Gly Ser Ser Arg Ser Ile 
    130                 135                 140                 


Cys Ser Gln Gly Gln Trp Ser Thr Pro Lys Pro His Cys Gln Gly Thr 
145                 150                 155                 160 


Leu Pro Ser Glu Thr Gln Ala Ser Ala Leu Pro Gly Leu Gln His Gly 
                165                 170                 175     


Gln Val Trp Glu Gly Ala Gly Asp Gln Ala Arg Glu Ala Gly Arg Gln 
            180                 185                 190         


Trp 
    


<210>  5651
<211>  961
<212>  PRT
<213>  Homo Sapiens

<400>  5651

Met Leu Leu Leu Leu Leu Leu Ala Pro Leu Phe Leu Arg Pro Pro Gly 
1               5                   10                  15      


Ala Gly Gly Ala Gln Thr Pro Asn Ala Thr Ser Glu Gly Cys Gln Ile 
            20                  25                  30          


Ile His Pro Pro Trp Glu Gly Gly Ile Arg Tyr Arg Gly Leu Thr Arg 
        35                  40                  45              


Asp Gln Val Lys Ala Ile Asn Phe Leu Pro Val Asp Tyr Glu Ile Glu 
    50                  55                  60                  


Tyr Val Cys Arg Gly Glu Arg Glu Val Val Gly Pro Lys Val Arg Lys 
65                  70                  75                  80  


Cys Leu Ala Asn Gly Ser Trp Thr Asp Met Asp Thr Pro Ser Arg Cys 
                85                  90                  95      


Val Arg Ile Cys Ser Lys Ser Tyr Leu Thr Leu Glu Asn Gly Lys Val 
            100                 105                 110         


Phe Leu Thr Gly Gly Asp Leu Pro Ala Leu Asp Gly Ala Arg Val Asp 
        115                 120                 125             


Phe Arg Cys Asp Pro Asp Phe His Leu Val Gly Ser Ser Arg Ser Ile 
    130                 135                 140                 


Cys Ser Gln Gly Gln Trp Ser Thr Pro Lys Pro His Cys Gln Val Asn 
145                 150                 155                 160 


Arg Thr Pro His Ser Glu Arg Arg Ala Val Tyr Ile Gly Ala Leu Phe 
                165                 170                 175     


Pro Met Ser Gly Gly Trp Pro Gly Gly Gln Ala Cys Gln Pro Ala Val 
            180                 185                 190         


Glu Met Ala Leu Glu Asp Val Asn Ser Arg Arg Asp Ile Leu Pro Asp 
        195                 200                 205             


Tyr Glu Leu Lys Leu Ile His His Asp Ser Lys Cys Asp Pro Gly Gln 
    210                 215                 220                 


Ala Thr Lys Tyr Leu Tyr Glu Leu Leu Tyr Asn Asp Pro Ile Lys Ile 
225                 230                 235                 240 


Ile Leu Met Pro Gly Cys Ser Ser Val Ser Thr Leu Val Ala Glu Ala 
                245                 250                 255     


Ala Arg Met Trp Asn Leu Ile Val Leu Ser Tyr Gly Ser Ser Ser Pro 
            260                 265                 270         


Ala Leu Ser Asn Arg Gln Arg Phe Pro Thr Phe Phe Arg Thr His Pro 
        275                 280                 285             


Ser Ala Thr Leu His Asn Pro Thr Arg Val Lys Leu Phe Glu Lys Trp 
    290                 295                 300                 


Gly Trp Lys Lys Ile Ala Thr Ile Gln Gln Thr Thr Glu Val Phe Thr 
305                 310                 315                 320 


Ser Thr Leu Asp Asp Leu Glu Glu Arg Val Lys Glu Ala Gly Ile Glu 
                325                 330                 335     


Ile Thr Phe Arg Gln Ser Phe Phe Ser Asp Pro Ala Val Pro Val Lys 
            340                 345                 350         


Asn Leu Lys Arg Gln Asp Ala Arg Ile Ile Val Gly Leu Phe Tyr Glu 
        355                 360                 365             


Thr Glu Ala Arg Lys Val Phe Cys Glu Val Tyr Lys Glu Arg Leu Phe 
    370                 375                 380                 


Gly Lys Lys Tyr Val Trp Phe Leu Ile Gly Trp Tyr Ala Asp Asn Trp 
385                 390                 395                 400 


Phe Lys Ile Tyr Asp Pro Ser Ile Asn Cys Thr Val Asp Glu Met Thr 
                405                 410                 415     


Glu Ala Val Glu Gly His Ile Thr Thr Glu Ile Val Met Leu Asn Pro 
            420                 425                 430         


Ala Asn Thr Arg Ser Ile Ser Asn Met Thr Ser Gln Glu Phe Val Glu 
        435                 440                 445             


Lys Leu Thr Lys Arg Leu Lys Arg His Pro Glu Glu Thr Gly Gly Phe 
    450                 455                 460                 


Gln Glu Ala Pro Leu Ala Tyr Asp Ala Ile Trp Ala Leu Ala Leu Ala 
465                 470                 475                 480 


Leu Asn Lys Thr Ser Gly Gly Gly Gly Arg Ser Gly Val Arg Leu Glu 
                485                 490                 495     


Asp Phe Asn Tyr Asn Asn Gln Thr Ile Thr Asp Gln Ile Tyr Arg Ala 
            500                 505                 510         


Met Asn Ser Ser Ser Phe Glu Gly Val Ser Gly His Val Val Phe Asp 
        515                 520                 525             


Ala Ser Gly Ser Arg Met Ala Trp Thr Leu Ile Glu Gln Leu Gln Gly 
    530                 535                 540                 


Gly Ser Tyr Lys Lys Ile Gly Tyr Tyr Asp Ser Thr Lys Asp Asp Leu 
545                 550                 555                 560 


Ser Trp Ser Lys Thr Asp Lys Trp Ile Gly Gly Ser Pro Pro Ala Asp 
                565                 570                 575     


Gln Thr Leu Val Ile Lys Thr Phe Arg Phe Leu Ser Gln Lys Leu Phe 
            580                 585                 590         


Ile Ser Val Ser Val Leu Ser Ser Leu Gly Ile Val Leu Ala Val Val 
        595                 600                 605             


Cys Leu Ser Phe Asn Ile Tyr Asn Ser His Val Arg Tyr Ile Gln Asn 
    610                 615                 620                 


Ser Gln Pro Asn Leu Asn Asn Leu Thr Ala Val Gly Cys Ser Leu Ala 
625                 630                 635                 640 


Leu Ala Ala Val Phe Pro Leu Gly Leu Asp Gly Tyr His Ile Gly Arg 
                645                 650                 655     


Asn Gln Phe Pro Phe Val Cys Gln Ala Arg Leu Trp Leu Leu Gly Leu 
            660                 665                 670         


Gly Phe Ser Leu Gly Tyr Gly Ser Met Phe Thr Lys Ile Trp Trp Val 
        675                 680                 685             


His Thr Val Phe Thr Lys Lys Glu Glu Lys Lys Glu Trp Arg Lys Thr 
    690                 695                 700                 


Leu Glu Pro Trp Lys Leu Tyr Ala Thr Val Gly Leu Leu Val Gly Met 
705                 710                 715                 720 


Asp Val Leu Thr Leu Ala Ile Trp Gln Ile Val Asp Pro Leu His Arg 
                725                 730                 735     


Thr Ile Glu Thr Phe Ala Lys Glu Glu Pro Lys Glu Asp Ile Asp Val 
            740                 745                 750         


Ser Ile Leu Pro Gln Leu Glu His Cys Ser Ser Arg Lys Met Asn Thr 
        755                 760                 765             


Trp Leu Gly Ile Phe Tyr Gly Tyr Lys Gly Leu Leu Leu Leu Leu Gly 
    770                 775                 780                 


Ile Phe Leu Ala Tyr Glu Thr Lys Ser Val Ser Thr Glu Lys Ile Asn 
785                 790                 795                 800 


Asp His Arg Ala Val Gly Met Ala Ile Tyr Asn Val Ala Val Leu Cys 
                805                 810                 815     


Leu Ile Thr Ala Pro Val Thr Met Ile Leu Ser Ser Gln Gln Asp Ala 
            820                 825                 830         


Ala Phe Ala Phe Ala Ser Leu Ala Ile Val Phe Ser Ser Tyr Ile Thr 
        835                 840                 845             


Leu Val Val Leu Phe Val Pro Lys Met Arg Arg Leu Ile Thr Arg Gly 
    850                 855                 860                 


Glu Trp Gln Ser Glu Ala Gln Asp Thr Met Lys Thr Gly Ser Ser Thr 
865                 870                 875                 880 


Asn Asn Asn Glu Glu Glu Lys Ser Arg Leu Leu Glu Lys Glu Asn Arg 
                885                 890                 895     


Glu Leu Glu Lys Ile Ile Ala Glu Lys Glu Glu Arg Val Ser Glu Leu 
            900                 905                 910         


Arg His Gln Leu Gln Ser Arg Gln Gln Leu Arg Ser Arg Arg His Pro 
        915                 920                 925             


Pro Thr Pro Pro Glu Pro Ser Gly Gly Leu Pro Arg Gly Pro Pro Glu 
    930                 935                 940                 


Pro Pro Asp Arg Leu Ser Cys Asp Gly Ser Arg Val His Leu Leu Tyr 
945                 950                 955                 960 


Lys 
    


<210>  5652
<211>  578
<212>  PRT
<213>  Homo Sapiens

<400>  5652

Met Leu Leu Leu Leu Leu Leu Ala Pro Leu Phe Leu Arg Pro Pro Gly 
1               5                   10                  15      


Ala Gly Gly Ala Gln Thr Pro Asn Ala Thr Ser Glu Gly Cys Gln Ile 
            20                  25                  30          


Ile His Pro Pro Trp Glu Gly Gly Ile Arg Tyr Arg Gly Leu Thr Arg 
        35                  40                  45              


Asp Gln Val Lys Ala Ile Asn Phe Leu Pro Val Asp Tyr Glu Ile Glu 
    50                  55                  60                  


Tyr Val Cys Arg Gly Glu Arg Glu Val Val Gly Pro Lys Val Arg Lys 
65                  70                  75                  80  


Cys Leu Ala Asn Gly Ser Trp Thr Asp Met Asp Thr Pro Ser Arg Cys 
                85                  90                  95      


Val Arg Ile Cys Ser Lys Ser Tyr Leu Thr Leu Glu Asn Gly Lys Val 
            100                 105                 110         


Phe Leu Thr Gly Gly Asp Leu Pro Ala Leu Asp Gly Ala Arg Val Asp 
        115                 120                 125             


Phe Arg Cys Asp Pro Asp Phe His Leu Val Gly Ser Ser Arg Ser Ile 
    130                 135                 140                 


Cys Ser Gln Gly Gln Trp Ser Thr Pro Lys Pro His Cys Gln Val Asn 
145                 150                 155                 160 


Arg Thr Pro His Ser Glu Arg Arg Ala Val Tyr Ile Gly Ala Leu Phe 
                165                 170                 175     


Pro Met Ser Gly Gly Trp Pro Gly Gly Gln Ala Cys Gln Pro Ala Val 
            180                 185                 190         


Glu Met Ala Leu Glu Asp Val Asn Ser Arg Arg Asp Ile Leu Pro Asp 
        195                 200                 205             


Tyr Glu Leu Lys Leu Ile His His Asp Ser Lys Cys Asp Pro Gly Gln 
    210                 215                 220                 


Ala Thr Lys Tyr Leu Tyr Glu Leu Leu Tyr Asn Asp Pro Ile Lys Ile 
225                 230                 235                 240 


Ile Leu Met Pro Gly Cys Ser Ser Val Ser Thr Leu Val Ala Glu Ala 
                245                 250                 255     


Ala Arg Met Trp Asn Leu Ile Val Leu Ser Tyr Gly Ser Ser Ser Pro 
            260                 265                 270         


Ala Leu Ser Asn Arg Gln Arg Phe Pro Thr Phe Phe Arg Thr His Pro 
        275                 280                 285             


Ser Ala Thr Leu His Asn Pro Thr Arg Val Lys Leu Phe Glu Lys Trp 
    290                 295                 300                 


Gly Trp Lys Lys Ile Ala Thr Ile Gln Gln Thr Thr Glu Val Phe Thr 
305                 310                 315                 320 


Ser Thr Leu Asp Asp Leu Glu Glu Arg Val Lys Glu Ala Gly Ile Glu 
                325                 330                 335     


Ile Thr Phe Arg Gln Ser Phe Phe Ser Asp Pro Ala Val Pro Val Lys 
            340                 345                 350         


Asn Leu Lys Arg Gln Asp Ala Arg Ile Ile Val Gly Leu Phe Tyr Glu 
        355                 360                 365             


Thr Glu Ala Arg Lys Val Phe Cys Glu Val Tyr Lys Glu Arg Leu Phe 
    370                 375                 380                 


Gly Lys Lys Tyr Val Trp Phe Leu Ile Gly Trp Tyr Ala Asp Asn Trp 
385                 390                 395                 400 


Phe Lys Ile Tyr Asp Pro Ser Ile Asn Cys Thr Val Asp Glu Met Thr 
                405                 410                 415     


Glu Ala Val Glu Gly His Ile Thr Thr Glu Ile Val Met Leu Asn Pro 
            420                 425                 430         


Ala Asn Thr Arg Ser Ile Ser Asn Met Thr Ser Gln Glu Phe Val Glu 
        435                 440                 445             


Lys Leu Thr Lys Arg Leu Lys Arg His Pro Glu Glu Thr Gly Gly Phe 
    450                 455                 460                 


Gln Glu Ala Pro Leu Ala Tyr Asp Ala Ile Trp Ala Leu Ala Leu Ala 
465                 470                 475                 480 


Leu Asn Lys Thr Ser Gly Gly Gly Gly Arg Ser Gly Val Arg Leu Glu 
                485                 490                 495     


Asp Phe Asn Tyr Asn Asn Gln Thr Ile Thr Asp Gln Ile Tyr Arg Ala 
            500                 505                 510         


Met Asn Ser Ser Ser Phe Glu Gly Val Ser Gly His Val Val Phe Asp 
        515                 520                 525             


Ala Ser Gly Ser Arg Met Ala Trp Thr Leu Ile Glu Gln Leu Gln Gly 
    530                 535                 540                 


Gly Ser Tyr Lys Lys Ile Gly Tyr Tyr Asp Ser Thr Lys Asp Asp Leu 
545                 550                 555                 560 


Ser Trp Ser Lys Thr Asp Lys Trp Ile Val Ile Ser Arg Thr His Ser 
                565                 570                 575     


Pro Thr 
        


<210>  5653
<211>  578
<212>  PRT
<213>  Homo Sapiens

<400>  5653

Met Leu Leu Leu Leu Leu Leu Ala Pro Leu Phe Leu Arg Pro Pro Gly 
1               5                   10                  15      


Ala Gly Gly Ala Gln Thr Pro Asn Ala Thr Ser Glu Gly Cys Gln Ile 
            20                  25                  30          


Ile His Pro Pro Trp Glu Gly Gly Ile Arg Tyr Arg Gly Leu Thr Arg 
        35                  40                  45              


Asp Gln Val Lys Ala Ile Asn Phe Leu Pro Val Asp Tyr Glu Ile Glu 
    50                  55                  60                  


Tyr Val Cys Arg Gly Glu Arg Glu Val Val Gly Pro Lys Val Arg Lys 
65                  70                  75                  80  


Cys Leu Ala Asn Gly Ser Trp Thr Asp Met Asp Thr Pro Ser Arg Cys 
                85                  90                  95      


Val Arg Ile Cys Ser Lys Ser Tyr Leu Thr Leu Glu Asn Gly Lys Val 
            100                 105                 110         


Phe Leu Thr Gly Gly Asp Leu Pro Ala Leu Asp Gly Ala Arg Val Asp 
        115                 120                 125             


Phe Arg Cys Asp Pro Asp Phe His Leu Val Gly Ser Ser Arg Ser Ile 
    130                 135                 140                 


Cys Ser Gln Gly Gln Trp Ser Thr Pro Lys Pro His Cys Gln Val Asn 
145                 150                 155                 160 


Arg Thr Pro His Ser Glu Arg Arg Ala Val Tyr Ile Gly Ala Leu Phe 
                165                 170                 175     


Pro Met Ser Gly Gly Trp Pro Gly Gly Gln Ala Cys Gln Pro Ala Val 
            180                 185                 190         


Glu Met Ala Leu Glu Asp Val Asn Ser Arg Arg Asp Ile Leu Pro Asp 
        195                 200                 205             


Tyr Glu Leu Lys Leu Ile His His Asp Ser Lys Cys Asp Pro Gly Gln 
    210                 215                 220                 


Ala Thr Lys Tyr Leu Tyr Glu Leu Leu Tyr Asn Asp Pro Ile Lys Ile 
225                 230                 235                 240 


Ile Leu Met Pro Gly Cys Ser Ser Val Ser Thr Leu Val Ala Glu Ala 
                245                 250                 255     


Ala Arg Met Trp Asn Leu Ile Val Leu Ser Tyr Gly Ser Ser Ser Pro 
            260                 265                 270         


Ala Leu Ser Asn Arg Gln Arg Phe Pro Thr Phe Phe Arg Thr His Pro 
        275                 280                 285             


Ser Ala Thr Leu His Asn Pro Thr Arg Val Lys Leu Phe Glu Lys Trp 
    290                 295                 300                 


Gly Trp Lys Lys Ile Ala Thr Ile Gln Gln Thr Thr Glu Val Phe Thr 
305                 310                 315                 320 


Ser Thr Leu Asp Asp Leu Glu Glu Arg Val Lys Glu Ala Gly Ile Glu 
                325                 330                 335     


Ile Thr Phe Arg Gln Ser Phe Phe Ser Asp Pro Ala Val Pro Val Lys 
            340                 345                 350         


Asn Leu Lys Arg Gln Asp Ala Arg Ile Ile Val Gly Leu Phe Tyr Glu 
        355                 360                 365             


Thr Glu Ala Arg Lys Val Phe Cys Glu Val Tyr Lys Glu Arg Leu Phe 
    370                 375                 380                 


Gly Lys Lys Tyr Val Trp Phe Leu Ile Gly Trp Tyr Ala Asp Asn Trp 
385                 390                 395                 400 


Phe Lys Ile Tyr Asp Pro Ser Ile Asn Cys Thr Val Asp Glu Met Thr 
                405                 410                 415     


Glu Ala Val Glu Gly His Ile Thr Thr Glu Ile Val Met Leu Asn Pro 
            420                 425                 430         


Ala Asn Thr Arg Ser Ile Ser Asn Met Thr Ser Gln Glu Phe Val Glu 
        435                 440                 445             


Lys Leu Thr Lys Arg Leu Lys Arg His Pro Glu Glu Thr Gly Gly Phe 
    450                 455                 460                 


Gln Glu Ala Pro Leu Ala Tyr Asp Ala Ile Trp Ala Leu Ala Leu Ala 
465                 470                 475                 480 


Leu Asn Lys Thr Ser Gly Gly Gly Gly Arg Ser Gly Val Arg Leu Glu 
                485                 490                 495     


Asp Phe Asn Tyr Asn Asn Gln Thr Ile Thr Asp Gln Ile Tyr Arg Ala 
            500                 505                 510         


Met Asn Ser Ser Ser Phe Glu Gly Val Ser Gly His Val Val Phe Asp 
        515                 520                 525             


Ala Ser Gly Ser Arg Met Ala Trp Thr Leu Ile Glu Gln Leu Gln Gly 
    530                 535                 540                 


Gly Ser Tyr Lys Lys Ile Gly Tyr Tyr Asp Ser Thr Lys Asp Asp Leu 
545                 550                 555                 560 


Ser Trp Ser Lys Thr Asp Lys Trp Ile Val Ile Ser Arg Thr His Ser 
                565                 570                 575     


Pro Thr 
        


<210>  5654
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  5654

Met Pro Gly Ala Trp Met Leu Leu Leu Leu Leu Leu Ala Pro Leu Phe 
1               5                   10                  15      


Leu Arg Pro Pro Gly Ala Gly Gly Ala Gln Thr Pro Asn Ala Thr Ser 
            20                  25                  30          


Glu Gly Cys Gln Ile Ile His Pro Pro Trp Glu Gly Gly Ile Arg Tyr 
        35                  40                  45              


Arg Gly Leu Thr Arg Asp Gln Val Lys Ala Ile Asn Phe Leu Pro Val 
    50                  55                  60                  


Asp Tyr Glu Ile Glu Tyr Val Cys Arg Gly Glu Arg Glu Val Val Gly 
65                  70                  75                  80  


Pro Lys Val Arg Lys Cys Leu Ala Asn Gly Ser Trp Thr Asp Met Asp 
                85                  90                  95      


Thr Pro Ser Arg Cys Val Arg Ile Cys Ser Lys Ser Tyr Leu Thr Leu 
            100                 105                 110         


Glu Asn Gly Lys Val Phe Leu Thr Gly Gly Asp Leu Pro Ala Leu Asp 
        115                 120                 125             


Gly Ala Arg Val Asp 
    130             


<210>  5655
<211>  70
<212>  PRT
<213>  Homo Sapiens

<400>  5655

Met Arg Lys Ser Pro Gly Leu Ser Asp Cys Leu Trp Ala Trp Ile Leu 
1               5                   10                  15      


Leu Leu Ser Thr Leu Thr Gly Arg Arg Thr Ser Arg Lys Ser His Gln 
            20                  25                  30          


Asn Thr Asp Leu Tyr Glu Val Asn Glu Gly Lys Asp Val Ala Met Asp 
        35                  40                  45              


Ser Arg His Tyr Lys Met Asn Leu Lys Thr Ile Pro Leu Ser Ser Pro 
    50                  55                  60                  


Gly Phe Trp Thr Asp Ser 
65                  70  


<210>  5656
<211>  35
<212>  PRT
<213>  Homo Sapiens

<400>  5656

Met Arg Lys Ser Pro Gly Leu Ser Asp Cys Leu Trp Ala Trp Ile Leu 
1               5                   10                  15      


Leu Leu Ser Thr Leu Thr Gly Arg Ser Tyr Gly Gln Pro Ser Leu Gln 
            20                  25                  30          


Asp Glu Leu 
        35  


<210>  5657
<211>  85
<212>  PRT
<213>  Homo Sapiens

<400>  5657

Met Arg Lys Ser Pro Gly Leu Ser Asp Cys Leu Trp Ala Trp Ile Leu 
1               5                   10                  15      


Leu Leu Ser Thr Leu Thr Gly Arg Ser Tyr Gly Gln Pro Ser Leu Gln 
            20                  25                  30          


Asp Glu Leu Lys Asp Asn Thr Thr Val Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Glu Arg 
    50                  55                  60                  


Val Thr Glu Val Lys Thr Asp Ile Phe Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp His Asp Met 
                85  


<210>  5658
<211>  168
<212>  PRT
<213>  Homo Sapiens

<400>  5658

Met Arg Lys Ser Pro Gly Leu Ser Asp Cys Leu Trp Ala Trp Ile Leu 
1               5                   10                  15      


Leu Leu Ser Thr Leu Thr Gly Arg Ser Tyr Gly Gln Pro Ser Leu Gln 
            20                  25                  30          


Asp Glu Leu Lys Asp Asn Thr Thr Val Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Glu Arg 
    50                  55                  60                  


Val Thr Glu Val Lys Thr Asp Ile Phe Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp His Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Ser 
                85                  90                  95      


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Thr Val Leu Arg 
            100                 105                 110         


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125             


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Thr Glu Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu 
145                 150                 155                 160 


Thr Val Arg Ala Glu Cys Pro Met 
                165             


<210>  5659
<211>  456
<212>  PRT
<213>  Homo Sapiens

<400>  5659

Met Arg Lys Ser Pro Gly Leu Ser Asp Cys Leu Trp Ala Trp Ile Leu 
1               5                   10                  15      


Leu Leu Ser Thr Leu Thr Gly Arg Ser Tyr Gly Gln Pro Ser Leu Gln 
            20                  25                  30          


Asp Glu Leu Lys Asp Asn Thr Thr Val Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Glu Arg 
    50                  55                  60                  


Val Thr Glu Val Lys Thr Asp Ile Phe Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp His Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Ser 
                85                  90                  95      


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Thr Val Leu Arg 
            100                 105                 110         


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125             


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Thr Glu Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu 
145                 150                 155                 160 


Thr Val Arg Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp 
                165                 170                 175     


Ala His Ala Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Arg Ala 
            180                 185                 190         


Glu Val Val Tyr Glu Trp Thr Arg Glu Pro Ala Arg Ser Val Val Val 
        195                 200                 205             


Ala Glu Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Thr 
    210                 215                 220                 


Val Asp Ser Gly Ile Val Gln Ser Ser Thr Gly Glu Tyr Val Val Met 
225                 230                 235                 240 


Thr Thr His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln 
                245                 250                 255     


Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe 
            260                 265                 270         


Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr 
        275                 280                 285             


Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu 
    290                 295                 300                 


Pro Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys 
305                 310                 315                 320 


Tyr Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr 
                325                 330                 335     


Phe Thr Lys Arg Gly Tyr Ala Trp Asp Gly Lys Ser Val Val Pro Glu 
            340                 345                 350         


Lys Pro Lys Lys Val Lys Asp Pro Leu Ile Lys Lys Asn Asn Thr Tyr 
        355                 360                 365             


Ala Pro Thr Ala Thr Ser Tyr Thr Pro Asn Leu Ala Arg Gly Asp Pro 
    370                 375                 380                 


Gly Leu Ala Thr Ile Ala Lys Ser Ala Thr Ile Glu Pro Lys Glu Val 
385                 390                 395                 400 


Lys Pro Glu Thr Lys Pro Pro Glu Pro Lys Lys Thr Phe Asn Ser Val 
                405                 410                 415     


Ser Lys Ile Asp Arg Leu Ser Arg Ile Ala Phe Pro Leu Leu Phe Gly 
            420                 425                 430         


Ile Phe Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Gln 
        435                 440                 445             


Leu Lys Ala Pro Thr Pro His Gln 
    450                 455     


<210>  5660
<211>  456
<212>  PRT
<213>  Homo Sapiens

<400>  5660

Met Arg Lys Ser Pro Gly Leu Ser Asp Cys Leu Trp Ala Trp Ile Leu 
1               5                   10                  15      


Leu Leu Ser Thr Leu Thr Gly Arg Ser Tyr Gly Gln Pro Ser Leu Gln 
            20                  25                  30          


Asp Glu Leu Lys Asp Asn Thr Thr Val Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Glu Arg 
    50                  55                  60                  


Val Thr Glu Val Lys Thr Asp Ile Phe Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp His Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Ser 
                85                  90                  95      


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Thr Val Leu Arg 
            100                 105                 110         


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125             


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Thr Glu Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu 
145                 150                 155                 160 


Thr Val Arg Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp 
                165                 170                 175     


Ala His Ala Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Arg Ala 
            180                 185                 190         


Glu Val Val Tyr Glu Trp Thr Arg Glu Pro Ala Arg Ser Val Val Val 
        195                 200                 205             


Ala Glu Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Thr 
    210                 215                 220                 


Val Asp Ser Gly Ile Val Gln Ser Ser Thr Gly Glu Tyr Val Val Met 
225                 230                 235                 240 


Thr Thr His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln 
                245                 250                 255     


Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe 
            260                 265                 270         


Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr 
        275                 280                 285             


Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu 
    290                 295                 300                 


Pro Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys 
305                 310                 315                 320 


Tyr Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr 
                325                 330                 335     


Phe Thr Lys Arg Gly Tyr Ala Trp Asp Gly Lys Ser Val Val Pro Glu 
            340                 345                 350         


Lys Pro Lys Lys Val Lys Asp Pro Leu Ile Lys Lys Asn Asn Thr Tyr 
        355                 360                 365             


Ala Pro Thr Ala Thr Ser Tyr Thr Pro Asn Leu Ala Arg Gly Asp Pro 
    370                 375                 380                 


Gly Leu Ala Thr Ile Ala Lys Ser Ala Thr Ile Glu Pro Lys Glu Val 
385                 390                 395                 400 


Lys Pro Glu Thr Lys Pro Pro Glu Pro Lys Lys Thr Phe Asn Ser Val 
                405                 410                 415     


Ser Lys Ile Asp Arg Leu Ser Arg Ile Ala Phe Pro Leu Leu Phe Gly 
            420                 425                 430         


Ile Phe Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Gln 
        435                 440                 445             


Leu Lys Ala Pro Thr Pro His Gln 
    450                 455     


<210>  5661
<211>  456
<212>  PRT
<213>  Homo Sapiens

<400>  5661

Met Arg Lys Ser Pro Gly Leu Ser Asp Cys Leu Trp Ala Trp Ile Leu 
1               5                   10                  15      


Leu Leu Ser Thr Leu Thr Gly Arg Ser Tyr Gly Gln Pro Ser Leu Gln 
            20                  25                  30          


Asp Glu Leu Lys Asp Asn Thr Thr Val Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Glu Arg 
    50                  55                  60                  


Val Thr Glu Val Lys Thr Asp Ile Phe Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp His Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Ser 
                85                  90                  95      


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Thr Val Leu Arg 
            100                 105                 110         


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125             


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Thr Glu Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu 
145                 150                 155                 160 


Thr Val Arg Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp 
                165                 170                 175     


Ala His Ala Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Arg Ala 
            180                 185                 190         


Glu Val Val Tyr Glu Trp Thr Arg Glu Pro Ala Arg Ser Val Val Val 
        195                 200                 205             


Ala Glu Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Thr 
    210                 215                 220                 


Val Asp Ser Gly Ile Val Gln Ser Ser Thr Gly Glu Tyr Val Val Met 
225                 230                 235                 240 


Thr Thr His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln 
                245                 250                 255     


Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe 
            260                 265                 270         


Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr 
        275                 280                 285             


Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu 
    290                 295                 300                 


Pro Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys 
305                 310                 315                 320 


Tyr Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr 
                325                 330                 335     


Phe Thr Lys Arg Gly Tyr Ala Trp Asp Gly Lys Ser Val Val Pro Glu 
            340                 345                 350         


Lys Pro Lys Lys Val Lys Asp Pro Leu Ile Lys Lys Asn Asn Thr Tyr 
        355                 360                 365             


Ala Pro Thr Ala Thr Ser Tyr Thr Pro Asn Leu Ala Arg Gly Asp Pro 
    370                 375                 380                 


Gly Leu Ala Thr Ile Ala Lys Ser Ala Thr Ile Glu Pro Lys Glu Val 
385                 390                 395                 400 


Lys Pro Glu Thr Lys Pro Pro Glu Pro Lys Lys Thr Phe Asn Ser Val 
                405                 410                 415     


Ser Lys Ile Asp Arg Leu Ser Arg Ile Ala Phe Pro Leu Leu Phe Gly 
            420                 425                 430         


Ile Phe Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Gln 
        435                 440                 445             


Leu Lys Ala Pro Thr Pro His Gln 
    450                 455     


<210>  5662
<211>  456
<212>  PRT
<213>  Homo Sapiens

<400>  5662

Met Arg Lys Ser Pro Gly Leu Ser Asp Cys Leu Trp Ala Trp Ile Leu 
1               5                   10                  15      


Leu Leu Ser Thr Leu Thr Gly Arg Ser Tyr Gly Gln Pro Ser Leu Gln 
            20                  25                  30          


Asp Glu Leu Lys Asp Asn Thr Thr Val Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Glu Arg 
    50                  55                  60                  


Val Thr Glu Val Lys Thr Asp Ile Phe Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp His Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Ser 
                85                  90                  95      


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Thr Val Leu Arg 
            100                 105                 110         


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125             


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Thr Glu Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu 
145                 150                 155                 160 


Thr Val Arg Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp 
                165                 170                 175     


Ala His Ala Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Arg Ala 
            180                 185                 190         


Glu Val Val Tyr Glu Trp Thr Arg Glu Pro Ala Arg Ser Val Val Val 
        195                 200                 205             


Ala Glu Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Thr 
    210                 215                 220                 


Val Asp Ser Gly Ile Val Gln Ser Ser Thr Gly Glu Tyr Val Val Met 
225                 230                 235                 240 


Thr Thr His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln 
                245                 250                 255     


Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe 
            260                 265                 270         


Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr 
        275                 280                 285             


Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu 
    290                 295                 300                 


Pro Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys 
305                 310                 315                 320 


Tyr Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr 
                325                 330                 335     


Phe Thr Lys Arg Gly Tyr Ala Trp Asp Gly Lys Ser Val Val Pro Glu 
            340                 345                 350         


Lys Pro Lys Lys Val Lys Asp Pro Leu Ile Lys Lys Asn Asn Thr Tyr 
        355                 360                 365             


Ala Pro Thr Ala Thr Ser Tyr Thr Pro Asn Leu Ala Arg Gly Asp Pro 
    370                 375                 380                 


Gly Leu Ala Thr Ile Ala Lys Ser Ala Thr Ile Glu Pro Lys Glu Val 
385                 390                 395                 400 


Lys Pro Glu Thr Lys Pro Pro Glu Pro Lys Lys Thr Phe Asn Ser Val 
                405                 410                 415     


Ser Lys Ile Asp Arg Leu Ser Arg Ile Ala Phe Pro Leu Leu Phe Gly 
            420                 425                 430         


Ile Phe Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Gln 
        435                 440                 445             


Leu Lys Ala Pro Thr Pro His Gln 
    450                 455     


<210>  5663
<211>  456
<212>  PRT
<213>  Homo Sapiens

<400>  5663

Met Arg Lys Ser Pro Gly Leu Ser Asp Cys Leu Trp Ala Trp Ile Leu 
1               5                   10                  15      


Leu Leu Ser Thr Leu Thr Gly Arg Ser Tyr Gly Gln Pro Ser Leu Gln 
            20                  25                  30          


Asp Glu Leu Lys Asp Asn Thr Thr Val Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Glu Arg 
    50                  55                  60                  


Val Thr Glu Val Lys Thr Asp Ile Phe Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp His Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Ser 
                85                  90                  95      


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Thr Val Leu Arg 
            100                 105                 110         


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125             


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Thr Glu Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu 
145                 150                 155                 160 


Thr Val Arg Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp 
                165                 170                 175     


Ala His Ala Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Arg Ala 
            180                 185                 190         


Glu Val Val Tyr Glu Trp Thr Arg Glu Pro Ala Arg Ser Val Val Val 
        195                 200                 205             


Ala Glu Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Thr 
    210                 215                 220                 


Val Asp Ser Gly Ile Val Gln Ser Ser Thr Gly Glu Tyr Val Val Met 
225                 230                 235                 240 


Thr Thr His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln 
                245                 250                 255     


Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe 
            260                 265                 270         


Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr 
        275                 280                 285             


Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu 
    290                 295                 300                 


Pro Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys 
305                 310                 315                 320 


Tyr Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr 
                325                 330                 335     


Phe Thr Lys Arg Gly Tyr Ala Trp Asp Gly Lys Ser Val Val Pro Glu 
            340                 345                 350         


Lys Pro Lys Lys Val Lys Asp Pro Leu Ile Lys Lys Asn Asn Thr Tyr 
        355                 360                 365             


Ala Pro Thr Ala Thr Ser Tyr Thr Pro Asn Leu Ala Arg Gly Asp Pro 
    370                 375                 380                 


Gly Leu Ala Thr Ile Ala Lys Ser Ala Thr Ile Glu Pro Lys Glu Val 
385                 390                 395                 400 


Lys Pro Glu Thr Lys Pro Pro Glu Pro Lys Lys Thr Phe Asn Ser Val 
                405                 410                 415     


Ser Lys Ile Asp Arg Leu Ser Arg Ile Ala Phe Pro Leu Leu Phe Gly 
            420                 425                 430         


Ile Phe Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Gln 
        435                 440                 445             


Leu Lys Ala Pro Thr Pro His Gln 
    450                 455     


<210>  5664
<211>  456
<212>  PRT
<213>  Homo Sapiens

<400>  5664

Met Arg Lys Ser Pro Gly Leu Ser Asp Cys Leu Trp Ala Trp Ile Leu 
1               5                   10                  15      


Leu Leu Ser Thr Leu Thr Gly Arg Ser Tyr Gly Gln Pro Ser Leu Gln 
            20                  25                  30          


Asp Glu Leu Lys Asp Asn Thr Thr Val Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Glu Arg 
    50                  55                  60                  


Val Thr Glu Val Lys Thr Asp Ile Phe Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp His Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Ser 
                85                  90                  95      


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Thr Val Leu Arg 
            100                 105                 110         


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125             


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Thr Glu Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu 
145                 150                 155                 160 


Thr Val Arg Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp 
                165                 170                 175     


Ala His Ala Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Arg Ala 
            180                 185                 190         


Glu Val Val Tyr Glu Trp Thr Arg Glu Pro Ala Arg Ser Val Val Val 
        195                 200                 205             


Ala Glu Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Thr 
    210                 215                 220                 


Val Asp Ser Gly Ile Val Gln Ser Ser Thr Gly Glu Tyr Val Val Met 
225                 230                 235                 240 


Thr Thr His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln 
                245                 250                 255     


Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe 
            260                 265                 270         


Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr 
        275                 280                 285             


Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu 
    290                 295                 300                 


Pro Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys 
305                 310                 315                 320 


Tyr Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr 
                325                 330                 335     


Phe Thr Lys Arg Gly Tyr Ala Trp Asp Gly Lys Ser Val Val Pro Glu 
            340                 345                 350         


Lys Pro Lys Lys Val Lys Asp Pro Leu Ile Lys Lys Asn Asn Thr Tyr 
        355                 360                 365             


Ala Pro Thr Ala Thr Ser Tyr Thr Pro Asn Leu Ala Arg Gly Asp Pro 
    370                 375                 380                 


Gly Leu Ala Thr Ile Ala Lys Ser Ala Thr Ile Glu Pro Lys Glu Val 
385                 390                 395                 400 


Lys Pro Glu Thr Lys Pro Pro Glu Pro Lys Lys Thr Phe Asn Ser Val 
                405                 410                 415     


Ser Lys Ile Asp Arg Leu Ser Arg Ile Ala Phe Pro Leu Leu Phe Gly 
            420                 425                 430         


Ile Phe Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Gln 
        435                 440                 445             


Leu Lys Ala Pro Thr Pro His Gln 
    450                 455     


<210>  5665
<211>  285
<212>  PRT
<213>  Homo Sapiens

<400>  5665

Met Arg Lys Ser Pro Gly Leu Ser Asp Cys Leu Trp Ala Trp Ile Leu 
1               5                   10                  15      


Leu Leu Ser Thr Leu Thr Gly Arg Ser Tyr Gly Gln Pro Ser Leu Gln 
            20                  25                  30          


Asp Glu Leu Lys Asp Asn Thr Thr Val Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Glu Arg 
    50                  55                  60                  


Val Thr Glu Val Lys Thr Asp Ile Phe Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp His Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Ser 
                85                  90                  95      


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Thr Val Leu Arg 
            100                 105                 110         


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125             


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Thr Glu Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu 
145                 150                 155                 160 


Thr Val Arg Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp 
                165                 170                 175     


Ala His Ala Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Arg Ala 
            180                 185                 190         


Glu Val Val Tyr Glu Trp Thr Arg Glu Pro Ala Arg Ser Val Val Val 
        195                 200                 205             


Ala Glu Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Thr 
    210                 215                 220                 


Val Asp Ser Gly Ile Val Gln Ser Ser Thr Gly Glu Tyr Val Val Met 
225                 230                 235                 240 


Thr Thr His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln 
                245                 250                 255     


Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe 
            260                 265                 270         


Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe 
        275                 280                 285 


<210>  5666
<211>  456
<212>  PRT
<213>  Homo Sapiens

<400>  5666

Met Arg Lys Ser Pro Gly Leu Ser Asp Cys Leu Trp Ala Trp Ile Leu 
1               5                   10                  15      


Leu Leu Ser Thr Leu Thr Gly Arg Ser Tyr Gly Gln Pro Ser Leu Gln 
            20                  25                  30          


Asp Glu Leu Lys Asp Asn Thr Thr Val Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Glu Arg 
    50                  55                  60                  


Val Thr Glu Val Lys Thr Asp Ile Phe Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp His Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Ser 
                85                  90                  95      


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Thr Val Leu Arg 
            100                 105                 110         


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125             


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Thr Glu Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu 
145                 150                 155                 160 


Thr Val Arg Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp 
                165                 170                 175     


Ala His Ala Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Arg Ala 
            180                 185                 190         


Glu Val Val Tyr Glu Trp Thr Arg Glu Pro Ala Arg Ser Val Val Val 
        195                 200                 205             


Ala Glu Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Thr 
    210                 215                 220                 


Val Asp Ser Gly Ile Val Gln Ser Ser Thr Gly Glu Tyr Val Val Met 
225                 230                 235                 240 


Thr Thr His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln 
                245                 250                 255     


Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe 
            260                 265                 270         


Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr 
        275                 280                 285             


Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu 
    290                 295                 300                 


Pro Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys 
305                 310                 315                 320 


Tyr Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr 
                325                 330                 335     


Phe Thr Lys Arg Gly Tyr Ala Trp Asp Gly Lys Ser Val Val Pro Glu 
            340                 345                 350         


Lys Pro Lys Lys Val Lys Asp Pro Leu Ile Lys Lys Asn Asn Thr Tyr 
        355                 360                 365             


Ala Pro Thr Ala Thr Ser Tyr Thr Pro Asn Leu Ala Arg Gly Asp Pro 
    370                 375                 380                 


Gly Leu Ala Thr Ile Ala Lys Ser Ala Thr Ile Glu Pro Lys Glu Val 
385                 390                 395                 400 


Lys Pro Glu Thr Lys Pro Pro Glu Pro Lys Lys Thr Phe Asn Ser Val 
                405                 410                 415     


Ser Lys Ile Asp Arg Leu Ser Arg Ile Ala Phe Pro Leu Leu Phe Gly 
            420                 425                 430         


Ile Phe Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Gln 
        435                 440                 445             


Leu Lys Ala Pro Thr Pro His Gln 
    450                 455     


<210>  5667
<211>  456
<212>  PRT
<213>  Homo Sapiens

<400>  5667

Met Arg Lys Ser Pro Gly Leu Ser Asp Cys Leu Trp Ala Trp Ile Leu 
1               5                   10                  15      


Leu Leu Ser Thr Leu Thr Gly Arg Ser Tyr Gly Gln Pro Ser Leu Gln 
            20                  25                  30          


Asp Glu Leu Lys Asp Asn Thr Thr Val Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Glu Arg 
    50                  55                  60                  


Val Thr Glu Val Lys Thr Asp Ile Phe Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp His Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Ser 
                85                  90                  95      


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Thr Val Leu Arg 
            100                 105                 110         


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125             


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Thr Glu Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu 
145                 150                 155                 160 


Thr Val Arg Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp 
                165                 170                 175     


Ala His Ala Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Arg Ala 
            180                 185                 190         


Glu Val Val Tyr Glu Trp Thr Arg Glu Pro Ala Arg Ser Val Val Val 
        195                 200                 205             


Ala Glu Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Thr 
    210                 215                 220                 


Val Asp Ser Gly Ile Val Gln Ser Ser Thr Gly Glu Tyr Val Val Met 
225                 230                 235                 240 


Thr Thr His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln 
                245                 250                 255     


Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe 
            260                 265                 270         


Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr 
        275                 280                 285             


Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu 
    290                 295                 300                 


Pro Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys 
305                 310                 315                 320 


Tyr Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr 
                325                 330                 335     


Phe Thr Lys Arg Gly Tyr Ala Trp Asp Gly Lys Ser Val Val Pro Glu 
            340                 345                 350         


Lys Pro Lys Lys Val Lys Asp Pro Leu Ile Lys Lys Asn Asn Thr Tyr 
        355                 360                 365             


Ala Pro Thr Ala Thr Ser Tyr Thr Pro Asn Leu Ala Arg Gly Asp Pro 
    370                 375                 380                 


Gly Leu Ala Thr Ile Ala Lys Ser Ala Thr Ile Glu Pro Lys Glu Val 
385                 390                 395                 400 


Lys Pro Glu Thr Lys Pro Pro Glu Pro Lys Lys Thr Phe Asn Ser Val 
                405                 410                 415     


Ser Lys Ile Asp Arg Leu Ser Arg Ile Ala Phe Pro Leu Leu Phe Gly 
            420                 425                 430         


Ile Phe Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Gln 
        435                 440                 445             


Leu Lys Ala Pro Thr Pro His Gln 
    450                 455     


<210>  5668
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  5668

Met Arg Lys Ser Pro Gly Leu Ser Asp Cys Leu Trp Ala Trp Ile Leu 
1               5                   10                  15      


Leu Leu Ser Thr Leu Thr Gly Arg Ser Tyr Gly Gln Pro Ser Leu Gln 
            20                  25                  30          


Asp Glu Leu Lys Asp Asn Thr Thr Val Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Glu Arg 
    50                  55                  60                  


Val Thr Glu Val Lys Thr Asp Ile Phe Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp His Asp Met Ile Phe Ala Leu Gln Asn Thr Ala Gln 
                85                  90                  


<210>  5669
<211>  471
<212>  PRT
<213>  Homo Sapiens

<400>  5669

Met Val Gln Val Ser Ile Ala Ser Asn Glu Leu Leu Gln Pro Ala Met 
1               5                   10                  15      


Arg Lys Ser Pro Gly Leu Ser Asp Cys Leu Trp Ala Trp Ile Leu Leu 
            20                  25                  30          


Leu Ser Thr Leu Thr Gly Arg Ser Tyr Gly Gln Pro Ser Leu Gln Asp 
        35                  40                  45              


Glu Leu Lys Asp Asn Thr Thr Val Phe Thr Arg Ile Leu Asp Arg Leu 
    50                  55                  60                  


Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Glu Arg Val 
65                  70                  75                  80  


Thr Glu Val Lys Thr Asp Ile Phe Val Thr Ser Phe Gly Pro Val Ser 
                85                  90                  95      


Asp His Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Ser Trp 
            100                 105                 110         


Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Thr Val Leu Arg Leu 
        115                 120                 125             


Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe His 
    130                 135                 140                 


Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys Leu 
145                 150                 155                 160 


Leu Arg Ile Thr Glu Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu Thr 
                165                 170                 175     


Val Arg Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp Ala 
            180                 185                 190         


His Ala Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Arg Ala Glu 
        195                 200                 205             


Val Val Tyr Glu Trp Thr Arg Glu Pro Ala Arg Ser Val Val Val Ala 
    210                 215                 220                 


Glu Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Thr Val 
225                 230                 235                 240 


Asp Ser Gly Ile Val Gln Ser Ser Thr Gly Glu Tyr Val Val Met Thr 
                245                 250                 255     


Thr His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln Thr 
            260                 265                 270         


Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe Trp 
        275                 280                 285             


Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr Thr 
    290                 295                 300                 


Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu Pro 
305                 310                 315                 320 


Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys Tyr 
                325                 330                 335     


Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr Phe 
            340                 345                 350         


Thr Lys Arg Gly Tyr Ala Trp Asp Gly Lys Ser Val Val Pro Glu Lys 
        355                 360                 365             


Pro Lys Lys Val Lys Asp Pro Leu Ile Lys Lys Asn Asn Thr Tyr Ala 
    370                 375                 380                 


Pro Thr Ala Thr Ser Tyr Thr Pro Asn Leu Ala Arg Gly Asp Pro Gly 
385                 390                 395                 400 


Leu Ala Thr Ile Ala Lys Ser Ala Thr Ile Glu Pro Lys Glu Val Lys 
                405                 410                 415     


Pro Glu Thr Lys Pro Pro Glu Pro Lys Lys Thr Phe Asn Ser Val Ser 
            420                 425                 430         


Lys Ile Asp Arg Leu Ser Arg Ile Ala Phe Pro Leu Leu Phe Gly Ile 
        435                 440                 445             


Phe Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Gln Leu 
    450                 455                 460                 


Lys Ala Pro Thr Pro His Gln 
465                 470     


<210>  5670
<211>  113
<212>  PRT
<213>  Homo Sapiens

<400>  5670

Met Val Gln Val Ser Ile Ala Ser Asn Glu Val Ser Tyr Pro Ser Glu 
1               5                   10                  15      


Leu Leu Gln Pro Ala Met Arg Lys Ser Pro Gly Leu Ser Asp Cys Leu 
            20                  25                  30          


Trp Ala Trp Ile Leu Leu Leu Ser Thr Leu Thr Gly Arg Ser Tyr Gly 
        35                  40                  45              


Gln Pro Ser Leu Gln Asp Glu Leu Lys Asp Asn Thr Thr Val Phe Thr 
    50                  55                  60                  


Arg Ile Leu Asp Arg Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro 
65                  70                  75                  80  


Gly Leu Gly Glu Arg Val Thr Glu Val Lys Thr Asp Ile Phe Val Thr 
                85                  90                  95      


Ser Phe Gly Pro Val Ser Asp His Asp Met Glu Tyr Thr Ile Asp Val 
            100                 105                 110         


Phe 
    


<210>  5671
<211>  427
<212>  PRT
<213>  Homo Sapiens

<400>  5671

Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Lys Trp Lys Asp Glu 
1               5                   10                  15      


Arg Leu Lys Phe Lys Gly Pro Met Asn Ile Leu Arg Leu Asn Asn Leu 
            20                  25                  30          


Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe His Asn Gly Lys 
        35                  40                  45              


Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys Leu Leu Arg Ile 
    50                  55                  60                  


Gln Asp Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu Thr Val Gln Ala 
65                  70                  75                  80  


Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp Ala His Ser Cys 
                85                  90                  95      


Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Thr Ser Glu Val Thr Tyr 
            100                 105                 110         


Ile Trp Thr Tyr Asn Ala Ser Asp Ser Val Gln Val Ala Pro Asp Gly 
        115                 120                 125             


Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Ser Ile Gly Lys Glu 
    130                 135                 140                 


Thr Ile Lys Ser Ser Thr Gly Glu Tyr Thr Val Met Thr Ala His Phe 
145                 150                 155                 160 


His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln Thr Tyr Leu Pro 
                165                 170                 175     


Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe Trp Leu Asn Arg 
            180                 185                 190         


Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr Thr Val Leu Thr 
        195                 200                 205             


Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu Pro Lys Val Ala 
    210                 215                 220                 


Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys Tyr Ala Phe Val 
225                 230                 235                 240 


Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr Phe Thr Lys Arg 
                245                 250                 255     


Gly Trp Ala Trp Asp Gly Lys Ser Val Val Asn Asp Lys Ser Pro Ser 
            260                 265                 270         


Ile Lys Ala Glu Gly Ile Thr Leu Thr Tyr Asn Ser Val Lys Ala Ile 
        275                 280                 285             


Leu Gln Gly Ala Lys Leu Ile Trp Ser Lys Tyr Ile Ala Phe Ser Trp 
    290                 295                 300                 


Pro Ser Leu Phe Gln Glu Lys Thr Leu Glu Tyr Leu Glu Lys Trp Met 
305                 310                 315                 320 


Asp Cys Leu Thr Phe Lys Gln Ser Ser Lys Lys Glu Lys Ala Ser Val 
                325                 330                 335     


Met Ile Gln Asn Asn Ala Tyr Ala Val Ala Val Ala Asn Tyr Ala Pro 
            340                 345                 350         


Asn Leu Ser Lys Asp Pro Val Leu Ser Thr Ile Ser Lys Ser Ala Thr 
        355                 360                 365             


Thr Pro Glu Pro Asn Lys Lys Pro Glu Asn Lys Pro Ala Glu Ala Lys 
    370                 375                 380                 


Lys Thr Phe Asn Ser Val Ser Lys Ile Asp Arg Met Ser Arg Ile Val 
385                 390                 395                 400 


Phe Pro Val Leu Phe Gly Thr Phe Asn Leu Val Tyr Trp Ala Thr Tyr 
                405                 410                 415     


Leu Asn Arg Glu Pro Val Leu Gly Val Ser Pro 
            420                 425         


<210>  5672
<211>  137
<212>  PRT
<213>  Homo Sapiens

<400>  5672

Met Lys Thr Lys Leu Asn Ile Tyr Asn Met Gln Phe Leu Leu Phe Val 
1               5                   10                  15      


Phe Leu Val Trp Asp Pro Ala Arg Leu Val Leu Ala Asn Ile Gln Glu 
            20                  25                  30          


Asp Glu Ala Lys Asn Asn Ile Thr Ile Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Asp Ser 
    50                  55                  60                  


Ile Thr Glu Val Phe Thr Asn Ile Tyr Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp Thr Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Lys 
                85                  90                  95      


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Asn Ile Leu Arg 
            100                 105                 110         


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125             


His Asn Gly Lys Lys Ser Val Ala His 
    130                 135         


<210>  5673
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  5673

Met Lys Thr Lys Leu Asn Ile Tyr Asn Met Gln Phe Leu Leu Phe Val 
1               5                   10                  15      


Phe Leu Val Trp Asp Pro Ala Arg Leu Val Leu Ala Asn Ile Gln Glu 
            20                  25                  30          


Asp Glu Ala Lys Asn Asn Ile Thr Ile Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Asp Ser 
    50                  55                  60                  


Ile Thr Glu Val Phe Thr Asn Ile Tyr Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp Thr Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Lys 
                85                  90                  95      


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Asn Ile Leu Arg 
            100                 105                 110         


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125             


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Gln Asp Asp Gly 
145                 150         


<210>  5674
<211>  159
<212>  PRT
<213>  Homo Sapiens

<400>  5674

Met Lys Thr Lys Leu Asn Ile Tyr Asn Met Gln Phe Leu Leu Phe Val 
1               5                   10                  15      


Phe Leu Val Trp Asp Pro Ala Arg Leu Val Leu Ala Asn Ile Gln Glu 
            20                  25                  30          


Asp Glu Ala Lys Asn Asn Ile Thr Ile Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Asp Ser 
    50                  55                  60                  


Ile Thr Glu Val Phe Thr Asn Ile Tyr Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp Thr Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Lys 
                85                  90                  95      


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Asn Ile Leu Arg 
            100                 105                 110         


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125             


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Gln Asp Asp Gly Thr Leu Leu Tyr Thr Met Arg 
145                 150                 155                 


<210>  5675
<211>  451
<212>  PRT
<213>  Homo Sapiens

<400>  5675

Met Lys Thr Lys Leu Asn Ile Tyr Asn Met Gln Phe Leu Leu Phe Val 
1               5                   10                  15      


Phe Leu Val Trp Asp Pro Ala Arg Leu Val Leu Ala Asn Ile Gln Glu 
            20                  25                  30          


Asp Glu Ala Lys Asn Asn Ile Thr Ile Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Asp Ser 
    50                  55                  60                  


Ile Thr Glu Val Phe Thr Asn Ile Tyr Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp Thr Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Lys 
                85                  90                  95      


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Asn Ile Leu Arg 
            100                 105                 110         


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125             


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Gln Asp Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu 
145                 150                 155                 160 


Thr Val Gln Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp 
                165                 170                 175     


Ala His Ser Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Thr Ser 
            180                 185                 190         


Glu Val Thr Tyr Ile Trp Thr Tyr Asn Ala Ser Asp Ser Val Gln Val 
        195                 200                 205             


Ala Pro Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Ser 
    210                 215                 220                 


Ile Gly Lys Glu Thr Ile Lys Ser Ser Thr Gly Glu Tyr Thr Val Met 
225                 230                 235                 240 


Thr Ala His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln 
                245                 250                 255     


Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe 
            260                 265                 270         


Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr 
        275                 280                 285             


Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu 
    290                 295                 300                 


Pro Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys 
305                 310                 315                 320 


Tyr Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr 
                325                 330                 335     


Phe Thr Lys Arg Gly Trp Ala Trp Asp Gly Lys Ser Val Val Asn Asp 
            340                 345                 350         


Lys Lys Lys Glu Lys Ala Ser Val Met Ile Gln Asn Asn Ala Tyr Ala 
        355                 360                 365             


Val Ala Val Ala Asn Tyr Ala Pro Asn Leu Ser Lys Asp Pro Val Leu 
    370                 375                 380                 


Ser Thr Ile Ser Lys Ser Ala Thr Thr Pro Glu Pro Asn Lys Lys Pro 
385                 390                 395                 400 


Glu Asn Lys Pro Ala Glu Ala Lys Lys Thr Phe Asn Ser Val Ser Lys 
                405                 410                 415     


Ile Asp Arg Met Ser Arg Ile Val Phe Pro Val Leu Phe Gly Thr Phe 
            420                 425                 430         


Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Val Leu Gly 
        435                 440                 445             


Val Ser Pro 
    450     


<210>  5676
<211>  451
<212>  PRT
<213>  Homo Sapiens

<400>  5676

Met Lys Thr Lys Leu Asn Ile Tyr Asn Met Gln Phe Leu Leu Phe Val 
1               5                   10                  15      


Phe Leu Val Trp Asp Pro Ala Arg Leu Val Leu Ala Asn Ile Gln Glu 
            20                  25                  30          


Asp Glu Ala Lys Asn Asn Ile Thr Ile Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Asp Ser 
    50                  55                  60                  


Ile Thr Glu Val Phe Thr Asn Ile Tyr Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp Thr Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Lys 
                85                  90                  95      


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Asn Ile Leu Arg 
            100                 105                 110         


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125             


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Gln Asp Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu 
145                 150                 155                 160 


Thr Val Gln Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp 
                165                 170                 175     


Ala His Ser Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Thr Ser 
            180                 185                 190         


Glu Val Thr Tyr Ile Trp Thr Tyr Asn Ala Ser Asp Ser Val Gln Val 
        195                 200                 205             


Ala Pro Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Ser 
    210                 215                 220                 


Ile Gly Lys Glu Thr Ile Lys Ser Ser Thr Gly Glu Tyr Thr Val Met 
225                 230                 235                 240 


Thr Ala His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln 
                245                 250                 255     


Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe 
            260                 265                 270         


Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr 
        275                 280                 285             


Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu 
    290                 295                 300                 


Pro Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys 
305                 310                 315                 320 


Tyr Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr 
                325                 330                 335     


Phe Thr Lys Arg Gly Trp Ala Trp Asp Gly Lys Ser Val Val Asn Asp 
            340                 345                 350         


Lys Lys Lys Glu Lys Ala Ser Val Met Ile Gln Asn Asn Ala Tyr Ala 
        355                 360                 365             


Val Ala Val Ala Asn Tyr Ala Pro Asn Leu Ser Lys Asp Pro Val Leu 
    370                 375                 380                 


Ser Thr Ile Ser Lys Ser Ala Thr Thr Pro Glu Pro Asn Lys Lys Pro 
385                 390                 395                 400 


Glu Asn Lys Pro Ala Glu Ala Lys Lys Thr Phe Asn Ser Val Ser Lys 
                405                 410                 415     


Ile Asp Arg Met Ser Arg Ile Val Phe Pro Val Leu Phe Gly Thr Phe 
            420                 425                 430         


Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Val Leu Gly 
        435                 440                 445             


Val Ser Pro 
    450     


<210>  5677
<211>  511
<212>  PRT
<213>  Homo Sapiens

<400>  5677

Met Lys Thr Lys Leu Asn Ile Tyr Asn Met Gln Phe Leu Leu Phe Val 
1               5                   10                  15      


Phe Leu Val Trp Asp Pro Ala Arg Leu Val Leu Ala Asn Ile Gln Glu 
            20                  25                  30          


Asp Glu Ala Lys Asn Asn Ile Thr Ile Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Asp Ser 
    50                  55                  60                  


Ile Thr Glu Val Phe Thr Asn Ile Tyr Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp Thr Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Lys 
                85                  90                  95      


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Asn Ile Leu Arg 
            100                 105                 110         


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125             


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Gln Asp Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu 
145                 150                 155                 160 


Thr Val Gln Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp 
                165                 170                 175     


Ala His Ser Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Thr Ser 
            180                 185                 190         


Glu Val Thr Tyr Ile Trp Thr Tyr Asn Ala Ser Asp Ser Val Gln Val 
        195                 200                 205             


Ala Pro Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Ser 
    210                 215                 220                 


Ile Gly Lys Glu Thr Ile Lys Ser Ser Thr Gly Glu Tyr Thr Val Met 
225                 230                 235                 240 


Thr Ala His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln 
                245                 250                 255     


Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe 
            260                 265                 270         


Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr 
        275                 280                 285             


Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu 
    290                 295                 300                 


Pro Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys 
305                 310                 315                 320 


Tyr Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr 
                325                 330                 335     


Phe Thr Lys Arg Gly Trp Ala Trp Asp Gly Lys Ser Val Val Asn Asp 
            340                 345                 350         


Lys Ser Pro Ser Ile Lys Ala Glu Gly Ile Thr Leu Thr Tyr Asn Ser 
        355                 360                 365             


Val Lys Ala Ile Leu Gln Gly Ala Lys Leu Ile Trp Ser Lys Tyr Ile 
    370                 375                 380                 


Ala Phe Ser Trp Pro Ser Leu Phe Gln Glu Lys Thr Leu Glu Tyr Leu 
385                 390                 395                 400 


Glu Lys Trp Met Asp Cys Leu Thr Phe Lys Gln Ser Ser Lys Lys Glu 
                405                 410                 415     


Lys Ala Ser Val Met Ile Gln Asn Asn Ala Tyr Ala Val Ala Val Ala 
            420                 425                 430         


Asn Tyr Ala Pro Asn Leu Ser Lys Asp Pro Val Leu Ser Thr Ile Ser 
        435                 440                 445             


Lys Ser Ala Thr Thr Pro Glu Pro Asn Lys Lys Pro Glu Asn Lys Pro 
    450                 455                 460                 


Ala Glu Ala Lys Lys Thr Phe Asn Ser Val Ser Lys Ile Asp Arg Met 
465                 470                 475                 480 


Ser Arg Ile Val Phe Pro Val Leu Phe Gly Thr Phe Asn Leu Val Tyr 
                485                 490                 495     


Trp Ala Thr Tyr Leu Asn Arg Glu Pro Val Leu Gly Val Ser Pro 
            500                 505                 510     


<210>  5678
<211>  451
<212>  PRT
<213>  Homo Sapiens

<400>  5678

Met Lys Thr Lys Leu Asn Ile Tyr Asn Met Gln Phe Leu Leu Phe Val 
1               5                   10                  15      


Phe Leu Val Trp Asp Pro Ala Arg Leu Val Leu Ala Asn Ile Gln Glu 
            20                  25                  30          


Asp Glu Ala Lys Asn Asn Ile Thr Ile Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Asp Ser 
    50                  55                  60                  


Ile Thr Glu Val Phe Thr Asn Ile Tyr Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp Thr Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Lys 
                85                  90                  95      


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Asn Ile Leu Arg 
            100                 105                 110         


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125             


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Gln Asp Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu 
145                 150                 155                 160 


Thr Val Gln Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp 
                165                 170                 175     


Ala His Ser Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Thr Ser 
            180                 185                 190         


Glu Val Thr Tyr Ile Trp Thr Tyr Asn Ala Ser Asp Ser Val Gln Val 
        195                 200                 205             


Ala Pro Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Ser 
    210                 215                 220                 


Ile Gly Lys Glu Thr Ile Lys Ser Ser Thr Gly Glu Tyr Thr Val Met 
225                 230                 235                 240 


Thr Ala His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln 
                245                 250                 255     


Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe 
            260                 265                 270         


Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr 
        275                 280                 285             


Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu 
    290                 295                 300                 


Pro Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys 
305                 310                 315                 320 


Tyr Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr 
                325                 330                 335     


Phe Thr Lys Arg Gly Trp Ala Trp Asp Gly Lys Ser Val Val Asn Asp 
            340                 345                 350         


Lys Lys Lys Glu Lys Ala Ser Val Met Ile Gln Asn Asn Ala Tyr Ala 
        355                 360                 365             


Val Ala Val Ala Asn Tyr Ala Pro Asn Leu Ser Lys Asp Pro Val Leu 
    370                 375                 380                 


Ser Thr Ile Ser Lys Ser Ala Thr Thr Pro Glu Pro Asn Lys Lys Pro 
385                 390                 395                 400 


Glu Asn Lys Pro Ala Glu Ala Lys Lys Thr Phe Asn Ser Val Ser Lys 
                405                 410                 415     


Ile Asp Arg Met Ser Arg Ile Val Phe Pro Val Leu Phe Gly Thr Phe 
            420                 425                 430         


Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Val Leu Gly 
        435                 440                 445             


Val Ser Pro 
    450     


<210>  5679
<211>  367
<212>  PRT
<213>  Homo Sapiens

<400>  5679

Met Lys Thr Lys Leu Asn Ile Tyr Asn Met Gln Phe Leu Leu Phe Val 
1               5                   10                  15      


Phe Leu Val Trp Asp Pro Ala Arg Leu Val Leu Ala Asn Ile Gln Glu 
            20                  25                  30          


Asp Glu Ala Lys Asn Asn Ile Thr Ile Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Asp Ser 
    50                  55                  60                  


Ile Thr Glu Val Phe Thr Asn Ile Tyr Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp Thr Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Lys 
                85                  90                  95      


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Asn Ile Leu Arg 
            100                 105                 110         


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125             


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Gln Asp Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu 
145                 150                 155                 160 


Thr Val Gln Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp 
                165                 170                 175     


Ala His Ser Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Thr Ser 
            180                 185                 190         


Glu Val Thr Tyr Ile Trp Thr Tyr Asn Ala Ser Asp Ser Val Gln Val 
        195                 200                 205             


Ala Pro Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Ser 
    210                 215                 220                 


Ile Gly Lys Glu Thr Ile Lys Ser Ser Thr Gly Glu Tyr Thr Val Met 
225                 230                 235                 240 


Thr Ala His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln 
                245                 250                 255     


Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe 
            260                 265                 270         


Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr 
        275                 280                 285             


Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu 
    290                 295                 300                 


Pro Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys 
305                 310                 315                 320 


Tyr Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr 
                325                 330                 335     


Phe Thr Lys Arg Gly Trp Ala Trp Asp Gly Lys Ser Val Val Asn Asp 
            340                 345                 350         


Lys Val Ser Glu Ser Phe Arg Val Ile Ile Ile Lys Lys Ile Pro 
        355                 360                 365         


<210>  5680
<211>  451
<212>  PRT
<213>  Homo Sapiens

<400>  5680

Met Lys Thr Lys Leu Asn Ile Tyr Asn Met Gln Phe Leu Leu Phe Val 
1               5                   10                  15      


Phe Leu Val Trp Asp Pro Ala Arg Leu Val Leu Ala Asn Ile Gln Glu 
            20                  25                  30          


Asp Glu Ala Lys Asn Asn Ile Thr Ile Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Asp Ser 
    50                  55                  60                  


Ile Thr Glu Val Phe Thr Asn Ile Tyr Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp Thr Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Lys 
                85                  90                  95      


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Asn Ile Leu Arg 
            100                 105                 110         


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125             


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Gln Asp Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu 
145                 150                 155                 160 


Thr Val Gln Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp 
                165                 170                 175     


Ala His Ser Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Thr Ser 
            180                 185                 190         


Glu Val Thr Tyr Ile Trp Thr Tyr Asn Ala Ser Asp Ser Val Gln Val 
        195                 200                 205             


Ala Pro Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Ser 
    210                 215                 220                 


Ile Gly Lys Glu Thr Ile Lys Ser Ser Thr Gly Glu Tyr Thr Val Met 
225                 230                 235                 240 


Thr Ala His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln 
                245                 250                 255     


Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe 
            260                 265                 270         


Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr 
        275                 280                 285             


Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu 
    290                 295                 300                 


Pro Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys 
305                 310                 315                 320 


Tyr Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr 
                325                 330                 335     


Phe Thr Lys Arg Gly Trp Ala Trp Asp Gly Lys Ser Val Val Asn Asp 
            340                 345                 350         


Lys Lys Lys Glu Lys Ala Ser Val Met Ile Gln Asn Asn Ala Tyr Ala 
        355                 360                 365             


Val Ala Val Ala Asn Tyr Ala Pro Asn Leu Ser Lys Asp Pro Val Leu 
    370                 375                 380                 


Ser Thr Ile Ser Lys Ser Ala Thr Thr Pro Glu Pro Asn Lys Lys Pro 
385                 390                 395                 400 


Glu Asn Lys Pro Ala Glu Ala Lys Lys Thr Phe Asn Ser Val Ser Lys 
                405                 410                 415     


Ile Asp Arg Met Ser Arg Ile Val Phe Pro Val Leu Phe Gly Thr Phe 
            420                 425                 430         


Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Val Leu Gly 
        435                 440                 445             


Val Ser Pro 
    450     


<210>  5681
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  5681

Met Lys Thr Lys Leu Asn Ile Tyr Asn Met Gln Phe Leu Leu Phe Val 
1               5                   10                  15      


Phe Leu Val Trp Asp Pro Ala Arg Leu Val Leu Ala Asn Ile Gln Glu 
            20                  25                  30          


Asp Glu Ala Lys Asn Asn Ile Thr Ile Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Gly Ile 
    50                  55                  60                  


Tyr Asn 
65      


<210>  5682
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  5682

Met Lys Thr Lys Leu Asn Ile Tyr Asn Met Gln Phe Leu Leu Phe Val 
1               5                   10                  15      


Phe Leu Val Trp Asp Pro Ala Arg Leu Val Leu Ala Asn Ile Gln Glu 
            20                  25                  30          


Asp Glu Ala Lys Asn Asn Ile Thr Ile Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Gly Ile 
    50                  55                  60                  


Tyr Asn 
65      


<210>  5683
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  5683

Met Lys Thr Lys Leu Asn Ile Tyr Asn Met Gln Phe Leu Leu Phe Val 
1               5                   10                  15      


Phe Leu Val Trp Asp Pro Ala Arg Leu Val Leu Ala Asn Ile Gln Glu 
            20                  25                  30          


Asp Glu Ala Lys Asn Asn Ile Thr Ile Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Gly Ile 
    50                  55                  60                  


Tyr Asn 
65      


<210>  5684
<211>  73
<212>  PRT
<213>  Homo Sapiens

<400>  5684

Met Lys Thr Lys Leu Asn Ile Tyr Asn Met Gln Phe Leu Leu Phe Val 
1               5                   10                  15      


Phe Leu Val Trp Asp Pro Ala Arg Leu Val Leu Ala Asn Ile Gln Glu 
            20                  25                  30          


Asp Glu Ala Lys Asn Asn Ile Thr Ile Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Val Ser 
    50                  55                  60                  


Arg Val Glu Ser Pro Val Cys Val Thr 
65                  70              


<210>  5685
<211>  56
<212>  PRT
<213>  Homo Sapiens

<400>  5685

Ser Ser Thr Gly Glu Tyr Thr Val Met Thr Ala His Phe His Leu Lys 
1               5                   10                  15      


Arg Lys Ile Gly Tyr Phe Val Ile Gln Thr Tyr Leu Pro Cys Ile Met 
            20                  25                  30          


Thr Val Ile Leu Ser Gln Val Ser Phe Trp Leu Asn Arg Glu Ser Val 
        35                  40                  45              


Pro Ala Arg Thr Val Phe Gly Glu 
    50                  55      


<210>  5686
<211>  16
<212>  PRT
<213>  Homo Sapiens

<400>  5686

Met Asp Asn Gly Met Phe Ser Gly Phe Ile Met Ile Lys Asn Leu Leu 
1               5                   10                  15      


<210>  5687
<211>  86
<212>  PRT
<213>  Homo Sapiens

<400>  5687

Met Asp Asn Gly Met Phe Ser Gly Phe Ile Met Ile Lys Asn Leu Leu 
1               5                   10                  15      


Leu Phe Cys Ile Ser Met Asn Leu Ser Ser His Phe Gly Phe Ser Gln 
            20                  25                  30          


Met Pro Thr Ser Ser Val Lys Asp Glu Thr Asn Asp Asn Ile Thr Ile 
        35                  40                  45              


Phe Thr Arg Ile Leu Asp Gly Leu Leu Asp Gly Tyr Asp Asn Arg Leu 
    50                  55                  60                  


Arg Pro Gly Leu Gly Glu Arg Ile Thr Gln Val Arg Thr Asp Ile Tyr 
65                  70                  75                  80  


Val Thr Ser Phe Gly Pro 
                85      


<210>  5688
<211>  149
<212>  PRT
<213>  Homo Sapiens

<400>  5688

Met Asp Asn Gly Met Phe Ser Gly Phe Ile Met Ile Lys Asn Leu Leu 
1               5                   10                  15      


Leu Phe Cys Ile Ser Met Asn Leu Ser Ser His Phe Gly Phe Ser Gln 
            20                  25                  30          


Met Pro Thr Ser Ser Val Lys Asp Glu Thr Asn Asp Asn Ile Thr Ile 
        35                  40                  45              


Phe Thr Arg Ile Leu Asp Gly Leu Leu Asp Gly Tyr Asp Asn Arg Leu 
    50                  55                  60                  


Arg Pro Gly Leu Gly Glu Arg Ile Thr Gln Val Arg Thr Asp Ile Tyr 
65                  70                  75                  80  


Val Thr Ser Phe Gly Pro Val Ser Asp Thr Glu Met Glu Tyr Thr Ile 
                85                  90                  95      


Asp Val Phe Phe Arg Gln Ser Trp Lys Asp Glu Arg Leu Arg Phe Lys 
            100                 105                 110         


Gly Pro Met Gln Arg Leu Pro Leu Asn Asn Leu Leu Ala Ser Lys Ile 
        115                 120                 125             


Trp Thr Pro Asp Thr Phe Phe His Asn Gly Lys Lys Ser Ile Ala His 
    130                 135                 140                 


Asn Met Thr Thr Pro 
145                 


<210>  5689
<211>  166
<212>  PRT
<213>  Homo Sapiens

<400>  5689

Met Asp Asn Gly Met Phe Ser Gly Phe Ile Met Ile Lys Asn Leu Leu 
1               5                   10                  15      


Leu Phe Cys Ile Ser Met Asn Leu Ser Ser His Phe Gly Phe Ser Gln 
            20                  25                  30          


Met Pro Thr Ser Ser Val Lys Asp Glu Thr Asn Asp Asn Ile Thr Ile 
        35                  40                  45              


Phe Thr Arg Ile Leu Asp Gly Leu Leu Asp Gly Tyr Asp Asn Arg Leu 
    50                  55                  60                  


Arg Pro Gly Leu Gly Glu Arg Ile Thr Gln Val Arg Thr Asp Ile Tyr 
65                  70                  75                  80  


Val Thr Ser Phe Gly Pro Val Ser Asp Thr Glu Met Glu Tyr Thr Ile 
                85                  90                  95      


Asp Val Phe Phe Arg Gln Ser Trp Lys Asp Glu Arg Leu Arg Phe Lys 
            100                 105                 110         


Gly Pro Met Gln Arg Leu Pro Leu Asn Asn Leu Leu Ala Ser Lys Ile 
        115                 120                 125             


Trp Thr Pro Asp Thr Phe Phe His Asn Gly Lys Lys Ser Ile Ala His 
    130                 135                 140                 


Asn Met Thr Thr Pro Asn Lys Leu Leu Arg Leu Glu Asp Asp Gly Thr 
145                 150                 155                 160 


Leu Leu Tyr Thr Met Arg 
                165     


<210>  5690
<211>  462
<212>  PRT
<213>  Homo Sapiens

<400>  5690

Met Asp Asn Gly Met Phe Ser Gly Phe Ile Met Ile Lys Asn Leu Leu 
1               5                   10                  15      


Leu Phe Cys Ile Ser Met Asn Leu Ser Ser His Phe Gly Phe Ser Gln 
            20                  25                  30          


Met Pro Thr Ser Ser Val Lys Asp Glu Thr Asn Asp Asn Ile Thr Ile 
        35                  40                  45              


Phe Thr Arg Ile Leu Asp Gly Leu Leu Asp Gly Tyr Asp Asn Arg Leu 
    50                  55                  60                  


Arg Pro Gly Leu Gly Glu Arg Ile Thr Gln Val Arg Thr Asp Ile Tyr 
65                  70                  75                  80  


Val Thr Ser Phe Gly Pro Val Ser Asp Thr Glu Met Glu Tyr Thr Ile 
                85                  90                  95      


Asp Val Phe Phe Arg Gln Ser Trp Lys Asp Glu Arg Leu Arg Phe Lys 
            100                 105                 110         


Gly Pro Met Gln Arg Leu Pro Leu Asn Asn Leu Leu Ala Ser Lys Ile 
        115                 120                 125             


Trp Thr Pro Asp Thr Phe Phe His Asn Gly Lys Lys Ser Ile Ala His 
    130                 135                 140                 


Asn Met Thr Thr Pro Asn Lys Leu Leu Arg Leu Glu Asp Asp Gly Thr 
145                 150                 155                 160 


Leu Leu Tyr Thr Met Arg Leu Thr Ile Ser Ala Glu Cys Pro Met Gln 
                165                 170                 175     


Leu Glu Asp Phe Pro Met Asp Ala His Ala Cys Pro Leu Lys Phe Gly 
            180                 185                 190         


Ser Tyr Ala Tyr Pro Asn Ser Glu Val Val Tyr Val Trp Thr Asn Gly 
        195                 200                 205             


Ser Thr Lys Ser Val Val Val Ala Glu Asp Gly Ser Arg Leu Asn Gln 
    210                 215                 220                 


Tyr His Leu Met Gly Gln Thr Val Gly Thr Glu Asn Ile Ser Thr Ser 
225                 230                 235                 240 


Thr Gly Glu Tyr Thr Ile Met Thr Ala His Phe His Leu Lys Arg Lys 
                245                 250                 255     


Ile Gly Tyr Phe Val Ile Gln Thr Tyr Leu Pro Cys Ile Met Thr Val 
            260                 265                 270         


Ile Leu Ser Gln Val Ser Phe Trp Leu Asn Arg Glu Ser Val Pro Ala 
        275                 280                 285             


Arg Thr Val Phe Gly Val Thr Thr Val Leu Thr Met Thr Thr Leu Ser 
    290                 295                 300                 


Ile Ser Ala Arg Asn Ser Leu Pro Lys Val Ala Tyr Ala Thr Ala Met 
305                 310                 315                 320 


Asp Trp Phe Ile Ala Val Cys Tyr Ala Phe Val Phe Ser Ala Leu Ile 
                325                 330                 335     


Glu Phe Ala Thr Val Asn Tyr Phe Thr Lys Arg Gly Trp Ala Trp Asp 
            340                 345                 350         


Gly Lys Lys Ala Leu Glu Ala Ala Lys Ile Lys Lys Lys Arg Glu Val 
        355                 360                 365             


Ile Leu Asn Lys Ser Thr Asn Ala Phe Thr Thr Gly Lys Met Ser His 
    370                 375                 380                 


Pro Pro Asn Ile Pro Lys Glu Gln Thr Pro Ala Gly Thr Ser Asn Thr 
385                 390                 395                 400 


Thr Ser Val Ser Val Lys Pro Ser Glu Glu Lys Thr Ser Glu Ser Lys 
                405                 410                 415     


Lys Thr Tyr Asn Ser Ile Ser Lys Ile Asp Lys Met Ser Arg Ile Val 
            420                 425                 430         


Phe Pro Val Leu Phe Gly Thr Phe Asn Leu Val Tyr Trp Ala Thr Tyr 
        435                 440                 445             


Leu Asn Arg Glu Pro Val Ile Lys Gly Ala Ala Ser Pro Lys 
    450                 455                 460         


<210>  5691
<211>  462
<212>  PRT
<213>  Homo Sapiens

<400>  5691

Met Asp Asn Gly Met Phe Ser Gly Phe Ile Met Ile Lys Asn Leu Leu 
1               5                   10                  15      


Leu Phe Cys Ile Ser Met Asn Leu Ser Ser His Phe Gly Phe Ser Gln 
            20                  25                  30          


Met Pro Thr Ser Ser Val Lys Asp Glu Thr Asn Asp Asn Ile Thr Ile 
        35                  40                  45              


Phe Thr Arg Ile Leu Asp Gly Leu Leu Asp Gly Tyr Asp Asn Arg Leu 
    50                  55                  60                  


Arg Pro Gly Leu Gly Glu Arg Ile Thr Gln Val Arg Thr Asp Ile Tyr 
65                  70                  75                  80  


Val Thr Ser Phe Gly Pro Val Ser Asp Thr Glu Met Glu Tyr Thr Ile 
                85                  90                  95      


Asp Val Phe Phe Arg Gln Ser Trp Lys Asp Glu Arg Leu Arg Phe Lys 
            100                 105                 110         


Gly Pro Met Gln Arg Leu Pro Leu Asn Asn Leu Leu Ala Ser Lys Ile 
        115                 120                 125             


Trp Thr Pro Asp Thr Phe Phe His Asn Gly Lys Lys Ser Ile Ala His 
    130                 135                 140                 


Asn Met Thr Thr Pro Asn Lys Leu Leu Arg Leu Glu Asp Asp Gly Thr 
145                 150                 155                 160 


Leu Leu Tyr Thr Met Arg Leu Thr Ile Ser Ala Glu Cys Pro Met Gln 
                165                 170                 175     


Leu Glu Asp Phe Pro Met Asp Ala His Ala Cys Pro Leu Lys Phe Gly 
            180                 185                 190         


Ser Tyr Ala Tyr Pro Asn Ser Glu Val Val Tyr Val Trp Thr Asn Gly 
        195                 200                 205             


Ser Thr Lys Ser Val Val Val Ala Glu Asp Gly Ser Arg Leu Asn Gln 
    210                 215                 220                 


Tyr His Leu Met Gly Gln Thr Val Gly Thr Glu Asn Ile Ser Thr Ser 
225                 230                 235                 240 


Thr Gly Glu Tyr Thr Ile Met Thr Ala His Phe His Leu Lys Arg Lys 
                245                 250                 255     


Ile Gly Tyr Phe Val Ile Gln Thr Tyr Leu Pro Cys Ile Met Thr Val 
            260                 265                 270         


Ile Leu Ser Gln Val Ser Phe Trp Leu Asn Arg Glu Ser Val Pro Ala 
        275                 280                 285             


Arg Thr Val Phe Gly Val Thr Thr Val Leu Thr Met Thr Thr Leu Ser 
    290                 295                 300                 


Ile Ser Ala Arg Asn Ser Leu Pro Lys Val Ala Tyr Ala Thr Ala Met 
305                 310                 315                 320 


Asp Trp Phe Ile Ala Val Cys Tyr Ala Phe Val Phe Ser Ala Leu Ile 
                325                 330                 335     


Glu Phe Ala Thr Val Asn Tyr Phe Thr Lys Arg Gly Trp Ala Trp Asp 
            340                 345                 350         


Gly Lys Lys Ala Leu Glu Ala Ala Lys Ile Lys Lys Lys Arg Glu Val 
        355                 360                 365             


Ile Leu Asn Lys Ser Thr Asn Ala Phe Thr Thr Gly Lys Met Ser His 
    370                 375                 380                 


Pro Pro Asn Ile Pro Lys Glu Gln Thr Pro Ala Gly Thr Ser Asn Thr 
385                 390                 395                 400 


Thr Ser Val Ser Val Lys Pro Ser Glu Glu Lys Thr Ser Glu Ser Lys 
                405                 410                 415     


Lys Thr Tyr Asn Ser Ile Ser Lys Ile Asp Lys Met Ser Arg Ile Val 
            420                 425                 430         


Phe Pro Val Leu Phe Gly Thr Phe Asn Leu Val Tyr Trp Ala Thr Tyr 
        435                 440                 445             


Leu Asn Arg Glu Pro Val Ile Lys Gly Ala Ala Ser Pro Lys 
    450                 455                 460         


<210>  5692
<211>  462
<212>  PRT
<213>  Homo Sapiens

<400>  5692

Met Asp Asn Gly Met Phe Ser Gly Phe Ile Met Ile Lys Asn Leu Leu 
1               5                   10                  15      


Leu Phe Cys Ile Ser Met Asn Leu Ser Ser His Phe Gly Phe Ser Gln 
            20                  25                  30          


Met Pro Thr Ser Ser Val Lys Asp Glu Thr Asn Asp Asn Ile Thr Ile 
        35                  40                  45              


Phe Thr Arg Ile Leu Asp Gly Leu Leu Asp Gly Tyr Asp Asn Arg Leu 
    50                  55                  60                  


Arg Pro Gly Leu Gly Glu Arg Ile Thr Gln Val Arg Thr Asp Ile Tyr 
65                  70                  75                  80  


Val Thr Ser Phe Gly Pro Val Ser Asp Thr Glu Met Glu Tyr Thr Ile 
                85                  90                  95      


Asp Val Phe Phe Arg Gln Ser Trp Lys Asp Glu Arg Leu Arg Phe Lys 
            100                 105                 110         


Gly Pro Met Gln Arg Leu Pro Leu Asn Asn Leu Leu Ala Ser Lys Ile 
        115                 120                 125             


Trp Thr Pro Asp Thr Phe Phe His Asn Gly Lys Lys Ser Ile Ala His 
    130                 135                 140                 


Asn Met Thr Thr Pro Asn Lys Leu Leu Arg Leu Glu Asp Asp Gly Thr 
145                 150                 155                 160 


Leu Leu Tyr Thr Met Arg Leu Thr Ile Ser Ala Glu Cys Pro Met Gln 
                165                 170                 175     


Leu Glu Asp Phe Pro Met Asp Ala His Ala Cys Pro Leu Lys Phe Gly 
            180                 185                 190         


Ser Tyr Ala Tyr Pro Asn Ser Glu Val Val Tyr Val Trp Thr Asn Gly 
        195                 200                 205             


Ser Thr Lys Ser Val Val Val Ala Glu Asp Gly Ser Arg Leu Asn Gln 
    210                 215                 220                 


Tyr His Leu Met Gly Gln Thr Val Gly Thr Glu Asn Ile Ser Thr Ser 
225                 230                 235                 240 


Thr Gly Glu Tyr Thr Ile Met Thr Ala His Phe His Leu Lys Arg Lys 
                245                 250                 255     


Ile Gly Tyr Phe Val Ile Gln Thr Tyr Leu Pro Cys Ile Met Thr Val 
            260                 265                 270         


Ile Leu Ser Gln Val Ser Phe Trp Leu Asn Arg Glu Ser Val Pro Ala 
        275                 280                 285             


Arg Thr Val Phe Gly Val Thr Thr Val Leu Thr Met Thr Thr Leu Ser 
    290                 295                 300                 


Ile Ser Ala Arg Asn Ser Leu Pro Lys Val Ala Tyr Ala Thr Ala Met 
305                 310                 315                 320 


Asp Trp Phe Ile Ala Val Cys Tyr Ala Phe Val Phe Ser Ala Leu Ile 
                325                 330                 335     


Glu Phe Ala Thr Val Asn Tyr Phe Thr Lys Arg Gly Trp Ala Trp Asp 
            340                 345                 350         


Gly Lys Lys Ala Leu Glu Ala Ala Lys Ile Lys Lys Lys Arg Glu Val 
        355                 360                 365             


Ile Leu Asn Lys Ser Thr Asn Ala Phe Thr Thr Gly Lys Met Ser His 
    370                 375                 380                 


Pro Pro Asn Ile Pro Lys Glu Gln Thr Pro Ala Gly Thr Ser Asn Thr 
385                 390                 395                 400 


Thr Ser Val Ser Val Lys Pro Ser Glu Glu Lys Thr Ser Glu Ser Lys 
                405                 410                 415     


Lys Thr Tyr Asn Ser Ile Ser Lys Ile Asp Lys Met Ser Arg Ile Val 
            420                 425                 430         


Phe Pro Val Leu Phe Gly Thr Phe Asn Leu Val Tyr Trp Ala Thr Tyr 
        435                 440                 445             


Leu Asn Arg Glu Pro Val Ile Lys Gly Ala Ala Ser Pro Lys 
    450                 455                 460         


<210>  5693
<211>  86
<212>  PRT
<213>  Homo Sapiens

<400>  5693

Met Pro Thr Ser Ser Val Lys Asp Glu Thr Asn Asp Asn Ile Thr Ile 
1               5                   10                  15      


Phe Thr Arg Ile Leu Asp Gly Leu Leu Asp Gly Tyr Asp Asn Arg Leu 
            20                  25                  30          


Arg Pro Gly Leu Gly Glu Arg Ile Thr Gln Val Arg Thr Asp Ile Tyr 
        35                  40                  45              


Val Thr Ser Phe Gly Pro Val Ser Asp Thr Glu Met Glu Tyr Thr Ile 
    50                  55                  60                  


Asp Val Phe Phe Arg Gln Ser Trp Lys Asp Glu Arg Leu Arg Phe Lys 
65                  70                  75                  80  


Gly Pro Met Gln Arg Leu 
                85      


<210>  5694
<211>  166
<212>  PRT
<213>  Homo Sapiens

<400>  5694

Met Pro Thr Ser Ser Val Lys Asp Glu Thr Asn Asp Asn Ile Thr Ile 
1               5                   10                  15      


Phe Thr Arg Ile Leu Asp Gly Leu Leu Asp Gly Tyr Asp Asn Arg Leu 
            20                  25                  30          


Arg Pro Gly Leu Gly Glu Arg Ile Thr Gln Val Arg Thr Asp Ile Tyr 
        35                  40                  45              


Val Thr Ser Phe Gly Pro Val Ser Asp Thr Glu Met Glu Tyr Thr Ile 
    50                  55                  60                  


Asp Val Phe Phe Arg Gln Ser Trp Lys Asp Glu Arg Leu Arg Phe Lys 
65                  70                  75                  80  


Gly Pro Met Gln Arg Leu Pro Leu Asn Asn Leu Leu Ala Ser Lys Ile 
                85                  90                  95      


Trp Thr Pro Asp Thr Phe Phe His Asn Gly Lys Lys Ser Ile Ala His 
            100                 105                 110         


Asn Met Thr Thr Pro Asn Lys Leu Leu Arg Leu Glu Asp Asp Gly Thr 
        115                 120                 125             


Leu Leu Tyr Thr Met Arg Leu Thr Ile Ser Ala Glu Cys Pro Met Gln 
    130                 135                 140                 


Leu Glu Asp Phe Pro Met Asp Ala His Ala Cys Pro Leu Lys Phe Gly 
145                 150                 155                 160 


Ser Tyr Ala Tyr Pro Asn 
                165     


<210>  5695
<211>  258
<212>  PRT
<213>  Homo Sapiens

<400>  5695

Glu Ala Gly Val Arg Gly Thr Glu Glu Asp Gly Cys Trp Val Cys Asn 
1               5                   10                  15      


Leu Glu Ser Val Ser Gln Ser Gln Thr Trp Gln Glu Asn Lys Leu Ser 
            20                  25                  30          


Glu Tyr Gln Ile Asp Ile Phe Phe Ala Gln Thr Trp Thr Asp Ser Arg 
        35                  40                  45              


Leu Arg Phe Asn Ser Thr Met Lys Ile Leu Thr Leu Asn Ser Asn Met 
    50                  55                  60                  


Val Gly Leu Ile Trp Ile Pro Asp Thr Ile Phe Arg Asn Ser Lys Thr 
65                  70                  75                  80  


Ala Glu Ala His Trp Ile Thr Thr Pro Asn Gln Leu Leu Arg Ile Trp 
                85                  90                  95      


Asn Asp Gly Lys Ile Leu Tyr Thr Leu Arg Leu Thr Ile Asn Ala Glu 
            100                 105                 110         


Cys Gln Leu Gln Leu His Asn Phe Pro Met Asp Glu His Ser Cys Pro 
        115                 120                 125             


Leu Ile Phe Ser Ser Tyr Gly Tyr Pro Lys Glu Glu Met Ile Tyr Arg 
    130                 135                 140                 


Trp Arg Lys Asn Ser Val Glu Ala Ala Asp Gln Lys Ser Trp Arg Leu 
145                 150                 155                 160 


Tyr Gln Phe Asp Phe Met Gly Leu Arg Asn Thr Thr Glu Ile Val Thr 
                165                 170                 175     


Thr Ser Ala Gly Asp Tyr Val Val Met Thr Ile Tyr Phe Glu Leu Ser 
            180                 185                 190         


Arg Arg Met Gly Tyr Phe Thr Ile Gln Thr Tyr Ile Pro Cys Ile Leu 
        195                 200                 205             


Thr Val Val Leu Ser Trp Val Ser Phe Trp Ile Lys Lys Asp Ala Thr 
    210                 215                 220                 


Pro Ala Arg Thr Ala Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr 
225                 230                 235                 240 


Leu Ser Thr Ile Ala Arg Lys Ser Leu Pro Arg Val Ser Tyr Val Thr 
                245                 250                 255     


Ala Met 
        


<210>  5696
<211>  467
<212>  PRT
<213>  Homo Sapiens

<400>  5696

Met Ala Pro Lys Leu Leu Leu Leu Leu Cys Leu Phe Ser Gly Leu His 
1               5                   10                  15      


Ala Arg Ser Arg Lys Val Glu Glu Asp Glu Tyr Glu Asp Ser Ser Ser 
            20                  25                  30          


Asn Gln Lys Trp Val Leu Ala Pro Lys Ser Gln Asp Thr Asp Val Thr 
        35                  40                  45              


Leu Ile Leu Asn Lys Leu Leu Arg Glu Tyr Asp Lys Lys Leu Arg Pro 
    50                  55                  60                  


Asp Ile Gly Ile Lys Pro Thr Val Ile Asp Val Asp Ile Tyr Val Asn 
65                  70                  75                  80  


Ser Ile Gly Pro Val Ser Ser Ile Asn Met Glu Tyr Gln Ile Asp Ile 
                85                  90                  95      


Phe Phe Ala Gln Thr Trp Thr Asp Ser Arg Leu Arg Phe Asn Ser Thr 
            100                 105                 110         


Met Lys Ile Leu Thr Leu Asn Ser Asn Met Val Gly Leu Ile Trp Ile 
        115                 120                 125             


Pro Asp Thr Ile Phe Arg Asn Ser Lys Thr Ala Glu Ala His Trp Ile 
    130                 135                 140                 


Thr Thr Pro Asn Gln Leu Leu Arg Ile Trp Asn Asp Gly Lys Ile Leu 
145                 150                 155                 160 


Tyr Thr Leu Arg Leu Thr Ile Asn Ala Glu Cys Gln Leu Gln Leu His 
                165                 170                 175     


Asn Phe Pro Met Asp Glu His Ser Cys Pro Leu Ile Phe Ser Ser Tyr 
            180                 185                 190         


Gly Tyr Pro Lys Glu Glu Met Ile Tyr Arg Trp Arg Lys Asn Ser Val 
        195                 200                 205             


Glu Ala Ala Asp Gln Lys Ser Trp Arg Leu Tyr Gln Phe Asp Phe Met 
    210                 215                 220                 


Gly Leu Arg Asn Thr Thr Glu Ile Val Thr Thr Ser Ala Gly Asp Tyr 
225                 230                 235                 240 


Val Val Met Thr Ile Tyr Phe Glu Leu Ser Arg Arg Met Gly Tyr Phe 
                245                 250                 255     


Thr Ile Gln Thr Tyr Ile Pro Cys Ile Leu Thr Val Val Leu Ser Trp 
            260                 265                 270         


Val Ser Phe Trp Ile Lys Lys Asp Ala Thr Pro Ala Arg Thr Ala Leu 
        275                 280                 285             


Gly Ile Thr Thr Val Leu Thr Met Thr Thr Leu Ser Thr Ile Ala Arg 
    290                 295                 300                 


Lys Ser Leu Pro Arg Val Ser Tyr Val Thr Ala Met Asp Leu Phe Val 
305                 310                 315                 320 


Thr Val Cys Phe Leu Phe Val Phe Ala Ala Leu Met Glu Tyr Ala Thr 
                325                 330                 335     


Leu Asn Tyr Tyr Ser Ser Cys Arg Lys Pro Thr Thr Thr Lys Lys Thr 
            340                 345                 350         


Thr Ser Leu Leu His Pro Asp Ser Ser Arg Trp Ile Pro Glu Arg Ile 
        355                 360                 365             


Ser Leu Gln Ala Pro Ser Asn Tyr Ser Leu Leu Asp Met Arg Pro Pro 
    370                 375                 380                 


Pro Thr Ala Met Ile Thr Leu Asn Asn Ser Val Tyr Trp Gln Glu Phe 
385                 390                 395                 400 


Glu Asp Thr Cys Val Tyr Glu Cys Leu Asp Gly Lys Asp Cys Gln Ser 
                405                 410                 415     


Phe Phe Cys Cys Tyr Glu Glu Cys Lys Ser Gly Ser Trp Arg Lys Gly 
            420                 425                 430         


Arg Ile His Ile Asp Ile Leu Glu Leu Asp Ser Tyr Ser Arg Val Phe 
        435                 440                 445             


Phe Pro Thr Ser Phe Leu Leu Phe Asn Leu Val Tyr Trp Val Gly Tyr 
    450                 455                 460                 


Leu Tyr Leu 
465         


<210>  5697
<211>  253
<212>  PRT
<213>  Homo Sapiens

<400>  5697

Met Ala Pro Lys Leu Leu Leu Leu Leu Cys Leu Phe Ser Gly Leu His 
1               5                   10                  15      


Ala Arg Ser Arg Lys Val Glu Glu Asp Glu Tyr Glu Asp Ser Ser Ser 
            20                  25                  30          


Asn Gln Lys Trp Val Leu Ala Pro Lys Ser Gln Asp Thr Asp Val Thr 
        35                  40                  45              


Leu Ile Leu Asn Lys Leu Leu Arg Glu Tyr Asp Lys Lys Leu Arg Pro 
    50                  55                  60                  


Asp Ile Gly Ile Lys Pro Thr Val Ile Asp Val Asp Ile Tyr Val Asn 
65                  70                  75                  80  


Ser Ile Gly Pro Val Ser Ser Ile Asn Met Glu Tyr Gln Ile Asp Ile 
                85                  90                  95      


Phe Phe Ala Gln Thr Trp Thr Asp Ser Arg Leu Arg Phe Asn Ser Thr 
            100                 105                 110         


Met Lys Ile Leu Thr Leu Asn Ser Asn Met Val Gly Leu Ile Trp Ile 
        115                 120                 125             


Pro Asp Thr Ile Phe Arg Asn Ser Lys Thr Ala Glu Ala His Trp Ile 
    130                 135                 140                 


Thr Thr Pro Asn Gln Leu Leu Arg Ile Trp Asn Asp Gly Lys Ile Leu 
145                 150                 155                 160 


Tyr Thr Leu Arg Leu Thr Ile Asn Ala Glu Cys Gln Leu Gln Leu His 
                165                 170                 175     


Asn Phe Pro Met Asp Glu His Ser Cys Pro Leu Ile Phe Ser Ser Tyr 
            180                 185                 190         


Gly Tyr Pro Lys Glu Glu Met Ile Tyr Arg Trp Arg Lys Asn Ser Val 
        195                 200                 205             


Glu Ala Ala Asp Gln Lys Ser Trp Arg Leu Tyr Gln Phe Asp Phe Met 
    210                 215                 220                 


Gly Leu Arg Asn Thr Thr Glu Ile Val Thr Thr Ser Ala Gly Arg Asn 
225                 230                 235                 240 


Leu Leu Lys Glu Ala Gln Leu Ser Lys Ala Arg Glu Ala 
                245                 250             


<210>  5698
<211>  288
<212>  PRT
<213>  Homo Sapiens

<400>  5698

Met Asp Glu His Ser Cys Pro Leu Ile Phe Ser Ser Tyr Gly Tyr Pro 
1               5                   10                  15      


Lys Glu Glu Met Ile Tyr Arg Trp Arg Lys Asn Ser Val Glu Ala Ala 
            20                  25                  30          


Asp Gln Lys Ser Trp Arg Leu Tyr Gln Phe Asp Phe Met Gly Leu Arg 
        35                  40                  45              


Asn Thr Thr Glu Ile Val Thr Thr Ser Ala Gly Asp Tyr Val Val Met 
    50                  55                  60                  


Thr Ile Tyr Phe Glu Leu Ser Arg Arg Met Gly Tyr Phe Thr Ile Gln 
65                  70                  75                  80  


Thr Tyr Ile Pro Cys Ile Leu Thr Val Val Leu Ser Trp Val Ser Phe 
                85                  90                  95      


Trp Ile Lys Lys Asp Ala Thr Pro Ala Arg Thr Ala Leu Gly Ile Thr 
            100                 105                 110         


Thr Val Leu Thr Met Thr Thr Leu Ser Thr Ile Ala Arg Lys Ser Leu 
        115                 120                 125             


Pro Arg Val Ser Tyr Val Thr Ala Met Asp Leu Phe Val Thr Val Cys 
    130                 135                 140                 


Phe Leu Phe Val Phe Ala Ala Leu Met Glu Tyr Ala Thr Leu Asn Tyr 
145                 150                 155                 160 


Tyr Ser Ser Cys Arg Lys Pro Thr Thr Thr Lys Lys Thr Thr Ser Leu 
                165                 170                 175     


Leu His Pro Asp Ser Ser Arg Trp Ile Pro Glu Arg Ile Ser Leu Gln 
            180                 185                 190         


Ala Pro Ser Asn Tyr Ser Leu Leu Asp Met Arg Pro Pro Pro Thr Ala 
        195                 200                 205             


Met Ile Thr Leu Asn Asn Ser Val Tyr Trp Gln Glu Phe Glu Asp Thr 
    210                 215                 220                 


Cys Val Tyr Glu Cys Leu Asp Gly Lys Asp Cys Gln Ser Phe Phe Cys 
225                 230                 235                 240 


Cys Tyr Glu Glu Cys Lys Ser Gly Ser Trp Arg Lys Gly Arg Ile His 
                245                 250                 255     


Ile Asp Ile Leu Glu Leu Asp Ser Tyr Ser Arg Val Phe Phe Pro Thr 
            260                 265                 270         


Ser Phe Leu Leu Phe Asn Leu Val Tyr Trp Val Gly Tyr Leu Tyr Leu 
        275                 280                 285             


<210>  5699
<211>  38
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5699

Xaa Ala Glu Cys Gln Leu Gln Leu His Asn Phe Pro Met Asp Glu His 
1               5                   10                  15      


Ser Cys Pro Leu Ile Phe Ser Ser Ser Thr Ile Leu Ala Phe Arg Leu 
            20                  25                  30          


Ser Leu His Ala Tyr Arg 
        35              


<210>  5700
<211>  169
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5700

Xaa Asp Tyr Val Val Met Thr Ile Tyr Phe Glu Leu Ser Arg Arg Met 
1               5                   10                  15      


Gly Tyr Phe Thr Ile Gln Thr Tyr Ile Pro Cys Ile Leu Thr Val Val 
            20                  25                  30          


Leu Ser Trp Val Ser Phe Trp Ile Lys Lys Asp Ala Thr Pro Ala Arg 
        35                  40                  45              


Thr Ala Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr Leu Ser Thr 
    50                  55                  60                  


Ile Ala Arg Lys Ser Leu Pro Arg Val Ser Tyr Val Thr Ala Met Asp 
65                  70                  75                  80  


Leu Phe Val Thr Val Cys Phe Leu Phe Val Phe Ala Ala Leu Met Glu 
                85                  90                  95      


Tyr Ala Thr Leu Asn Tyr Tyr Ser Ser Cys Arg Lys Pro Thr Thr Thr 
            100                 105                 110         


Lys Lys Thr Thr Ser Leu Leu His Pro Asp Ser Ser Arg Trp Ile Pro 
        115                 120                 125             


Glu Arg Ile Ser Leu Gln Ala Pro Ser Lys Pro Ser Cys Cys Pro Ala 
    130                 135                 140                 


Cys Gly Leu Gln Gly Leu Pro Phe Arg Ser Leu Val Ser His Pro Arg 
145                 150                 155                 160 


Ile Ser Arg Ala Phe Cys Leu Pro Val 
                165                 


<210>  5701
<211>  52
<212>  PRT
<213>  Homo Sapiens

<400>  5701

Met Asn Tyr Ser Leu His Leu Ala Phe Val Cys Leu Ser Leu Phe Thr 
1               5                   10                  15      


Glu Arg Met Cys Ile Gln Gly Ser Gln Phe Asn Val Glu Val Gly Arg 
            20                  25                  30          


Ser Asp Lys Leu Ser Leu Pro Gly Phe Glu Asn Leu Thr Ala Gly Tyr 
        35                  40                  45              


Asn Lys Phe Leu 
    50          


<210>  5702
<211>  59
<212>  PRT
<213>  Homo Sapiens

<400>  5702

Met Asn Tyr Ser Leu His Leu Ala Phe Val Cys Leu Ser Leu Phe Thr 
1               5                   10                  15      


Glu Arg Met Cys Ile Gln Gly Ser Gln Phe Asn Val Glu Val Gly Arg 
            20                  25                  30          


Ser Asp Lys Leu Ser Leu Pro Gly Phe Glu Asn Leu Thr Ala Gly Tyr 
        35                  40                  45              


Asn Lys Phe Leu Arg Pro Asn Phe Gly Gly Glu 
    50                  55                  


<210>  5703
<211>  92
<212>  PRT
<213>  Homo Sapiens

<400>  5703

Met Asn Tyr Ser Leu His Leu Ala Phe Val Cys Leu Ser Leu Phe Thr 
1               5                   10                  15      


Glu Arg Met Cys Ile Gln Gly Ser Gln Phe Asn Val Glu Val Gly Arg 
            20                  25                  30          


Ser Asp Lys Leu Ser Leu Pro Gly Phe Glu Asn Leu Thr Ala Gly Tyr 
        35                  40                  45              


Asn Lys Phe Leu Arg Pro Asn Phe Gly Gly Glu Pro Val Gln Ile Ala 
    50                  55                  60                  


Leu Thr Leu Asp Ile Ala Ser Ile Ser Ser Ile Ser Glu Ser Asn Met 
65                  70                  75                  80  


Asp Tyr Thr Ala Thr Ile Tyr Leu Arg Gln Arg Trp 
                85                  90          


<210>  5704
<211>  171
<212>  PRT
<213>  Homo Sapiens

<400>  5704

Met Asn Tyr Ser Leu His Leu Ala Phe Val Cys Leu Ser Leu Phe Thr 
1               5                   10                  15      


Glu Arg Met Cys Ile Gln Gly Ser Gln Phe Asn Val Glu Val Gly Arg 
            20                  25                  30          


Ser Asp Lys Leu Ser Leu Pro Gly Phe Glu Asn Leu Thr Ala Gly Tyr 
        35                  40                  45              


Asn Lys Phe Leu Arg Pro Asn Phe Gly Gly Glu Pro Val Gln Ile Ala 
    50                  55                  60                  


Leu Thr Leu Asp Ile Ala Ser Ile Ser Ser Ile Ser Glu Ser Asn Met 
65                  70                  75                  80  


Asp Tyr Thr Ala Thr Ile Tyr Leu Arg Gln Arg Trp Met Asp Gln Arg 
                85                  90                  95      


Leu Val Phe Glu Gly Asn Lys Ser Phe Thr Leu Asp Ala Arg Leu Val 
            100                 105                 110         


Glu Phe Leu Trp Val Pro Asp Thr Tyr Ile Val Glu Ser Lys Lys Ser 
        115                 120                 125             


Phe Leu His Glu Val Thr Val Gly Asn Arg Leu Ile Arg Leu Phe Ser 
    130                 135                 140                 


Asn Gly Thr Val Leu Tyr Ala Leu Arg Ile Thr Thr Thr Val Ala Cys 
145                 150                 155                 160 


Asn Met Asp Leu Ser Lys Tyr Pro Met Asp Thr 
                165                 170     


<210>  5705
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  5705

Met Asn Tyr Ser Leu His Leu Ala Phe Val Cys Leu Ser Leu Phe Thr 
1               5                   10                  15      


Glu Arg Met Cys Ile Gln Gly Ser Gln Phe Asn Val Glu Val Gly Arg 
            20                  25                  30          


Ser Asp Lys Leu Ser Leu Pro Gly Phe Glu Asn Leu Thr Ala Gly Tyr 
        35                  40                  45              


Asn Lys Phe Leu Arg Pro Asn Phe Gly Gly Glu Pro Val Gln Ile Ala 
    50                  55                  60                  


Leu Thr Leu Asp Ile Ala Ser Ile Ser Ser Ile Ser Glu Ser Asn Met 
65                  70                  75                  80  


Asp Tyr Thr Ala Thr Ile Tyr Leu Arg Gln Arg Trp Met Asp Gln Arg 
                85                  90                  95      


Leu Val Phe Glu Gly Asn Lys Ser Phe Thr Leu Asp Ala Arg Leu Val 
            100                 105                 110         


Glu Phe Leu Trp Val Pro Asp Thr Tyr Ile Val Glu Ser Lys Lys Ser 
        115                 120                 125             


Phe Leu His Glu Val Thr Val Gly Asn Arg Leu Ile Arg Leu Phe Ser 
    130                 135                 140                 


Asn Gly Thr Val Leu Tyr Ala Leu Arg Ile Thr Thr Thr Val Ala Cys 
145                 150                 155                 160 


Asn Met Asp Leu Ser Lys Tyr Pro Met Asp Thr Gln Thr Cys Lys Leu 
                165                 170                 175     


Gln Leu Glu Ser Trp Gly Tyr Asp Gly Asn Asp Val Glu 
            180                 185                 


<210>  5706
<211>  440
<212>  PRT
<213>  Homo Sapiens

<400>  5706

Met Asn Tyr Ser Leu His Leu Ala Phe Val Cys Leu Ser Leu Phe Thr 
1               5                   10                  15      


Glu Arg Met Cys Ile Gln Gly Ser Gln Phe Asn Val Glu Val Gly Arg 
            20                  25                  30          


Ser Asp Lys Leu Ser Leu Pro Gly Phe Glu Asn Leu Thr Ala Gly Tyr 
        35                  40                  45              


Asn Lys Phe Leu Arg Pro Asn Phe Gly Gly Glu Pro Val Gln Ile Ala 
    50                  55                  60                  


Leu Thr Leu Asp Ile Ala Ser Ile Ser Ser Ile Ser Glu Ser Asn Met 
65                  70                  75                  80  


Asp Tyr Thr Ala Thr Ile Tyr Leu Arg Gln Arg Trp Met Asp Gln Arg 
                85                  90                  95      


Leu Val Phe Glu Gly Asn Lys Ser Phe Thr Leu Asp Ala Arg Leu Val 
            100                 105                 110         


Glu Phe Leu Trp Val Pro Asp Thr Tyr Ile Val Glu Ser Lys Lys Ser 
        115                 120                 125             


Phe Leu His Glu Val Thr Val Gly Asn Arg Leu Ile Arg Leu Phe Ser 
    130                 135                 140                 


Asn Gly Thr Val Leu Tyr Ala Leu Arg Ile Thr Thr Thr Val Ala Cys 
145                 150                 155                 160 


Asn Met Asp Leu Ser Lys Tyr Pro Met Asp Thr Gln Thr Cys Lys Leu 
                165                 170                 175     


Gln Leu Glu Ser Trp Gly Tyr Asp Gly Asn Asp Val Glu Phe Thr Trp 
            180                 185                 190         


Leu Arg Gly Asn Asp Ser Val Arg Gly Leu Glu His Leu Arg Leu Ala 
        195                 200                 205             


Gln Tyr Thr Ile Glu Arg Tyr Phe Thr Leu Val Thr Arg Ser Gln Gln 
    210                 215                 220                 


Glu Thr Gly Asn Tyr Thr Arg Leu Val Leu Gln Phe Glu Leu Arg Arg 
225                 230                 235                 240 


Asn Val Leu Tyr Phe Ile Leu Glu Thr Tyr Val Pro Ser Thr Phe Leu 
                245                 250                 255     


Val Val Leu Ser Trp Val Ser Phe Trp Ile Ser Leu Asp Ser Val Pro 
            260                 265                 270         


Ala Arg Thr Cys Ile Gly Val Thr Thr Val Leu Ser Met Thr Thr Leu 
        275                 280                 285             


Met Ile Gly Ser Arg Thr Ser Leu Pro Asn Thr Asn Cys Phe Ile Lys 
    290                 295                 300                 


Ala Ile Asp Val Tyr Leu Gly Ile Cys Phe Ser Phe Val Phe Gly Ala 
305                 310                 315                 320 


Leu Leu Glu Tyr Ala Val Ala His Tyr Ser Ser Leu Gln Gln Met Ala 
                325                 330                 335     


Ala Lys Asp Arg Gly Thr Thr Lys Glu Val Glu Glu Val Ser Ile Thr 
            340                 345                 350         


Asn Ile Ile Asn Ser Ser Ile Ser Ser Phe Lys Arg Lys Ile Ser Phe 
        355                 360                 365             


Ala Ser Ile Glu Ile Ser Ser Asp Asn Val Asp Tyr Ser Asp Leu Thr 
    370                 375                 380                 


Met Lys Thr Ser Asp Lys Phe Lys Phe Val Phe Arg Glu Lys Met Gly 
385                 390                 395                 400 


Arg Ile Val Asp Tyr Phe Thr Ile Gln Asn Pro Ser Asn Val Asp His 
                405                 410                 415     


Tyr Ser Lys Leu Leu Phe Pro Leu Ile Phe Met Leu Ala Asn Val Phe 
            420                 425                 430         


Tyr Trp Ala Tyr Tyr Met Tyr Phe 
        435                 440 


<210>  5707
<211>  440
<212>  PRT
<213>  Homo Sapiens

<400>  5707

Met Asn Tyr Ser Leu His Leu Ala Phe Val Cys Leu Ser Leu Phe Thr 
1               5                   10                  15      


Glu Arg Met Cys Ile Gln Gly Ser Gln Phe Asn Val Glu Val Gly Arg 
            20                  25                  30          


Ser Asp Lys Leu Ser Leu Pro Gly Phe Glu Asn Leu Thr Ala Gly Tyr 
        35                  40                  45              


Asn Lys Phe Leu Arg Pro Asn Phe Gly Gly Glu Pro Val Gln Ile Ala 
    50                  55                  60                  


Leu Thr Leu Asp Ile Ala Ser Ile Ser Ser Ile Ser Glu Ser Asn Met 
65                  70                  75                  80  


Asp Tyr Thr Ala Thr Ile Tyr Leu Arg Gln Arg Trp Met Asp Gln Arg 
                85                  90                  95      


Leu Val Phe Glu Gly Asn Lys Ser Phe Thr Leu Asp Ala Arg Leu Val 
            100                 105                 110         


Glu Phe Leu Trp Val Pro Asp Thr Tyr Ile Val Glu Ser Lys Lys Ser 
        115                 120                 125             


Phe Leu His Glu Val Thr Val Gly Asn Arg Leu Ile Arg Leu Phe Ser 
    130                 135                 140                 


Asn Gly Thr Val Leu Tyr Ala Leu Arg Ile Thr Thr Thr Val Ala Cys 
145                 150                 155                 160 


Asn Met Asp Leu Ser Lys Tyr Pro Met Asp Thr Gln Thr Cys Lys Leu 
                165                 170                 175     


Gln Leu Glu Ser Trp Gly Tyr Asp Gly Asn Asp Val Glu Phe Thr Trp 
            180                 185                 190         


Leu Arg Gly Asn Asp Ser Val Arg Gly Leu Glu His Leu Arg Leu Ala 
        195                 200                 205             


Gln Tyr Thr Ile Glu Arg Tyr Phe Thr Leu Val Thr Arg Ser Gln Gln 
    210                 215                 220                 


Glu Thr Gly Asn Tyr Thr Arg Leu Val Leu Gln Phe Glu Leu Arg Arg 
225                 230                 235                 240 


Asn Val Leu Tyr Phe Ile Leu Glu Thr Tyr Val Pro Ser Thr Phe Leu 
                245                 250                 255     


Val Val Leu Ser Trp Val Ser Phe Trp Ile Ser Leu Asp Ser Val Pro 
            260                 265                 270         


Ala Arg Thr Cys Ile Gly Val Thr Thr Val Leu Ser Met Thr Thr Leu 
        275                 280                 285             


Met Ile Gly Ser Arg Thr Ser Leu Pro Asn Thr Asn Cys Phe Ile Lys 
    290                 295                 300                 


Ala Ile Asp Val Tyr Leu Gly Ile Cys Phe Ser Phe Val Phe Gly Ala 
305                 310                 315                 320 


Leu Leu Glu Tyr Ala Val Ala His Tyr Ser Ser Leu Gln Gln Met Ala 
                325                 330                 335     


Ala Lys Asp Arg Gly Thr Thr Lys Glu Val Glu Glu Val Ser Ile Thr 
            340                 345                 350         


Asn Ile Ile Asn Ser Ser Ile Ser Ser Phe Lys Arg Lys Ile Ser Phe 
        355                 360                 365             


Ala Ser Ile Glu Ile Ser Ser Asp Asn Val Asp Tyr Ser Asp Leu Thr 
    370                 375                 380                 


Met Lys Thr Ser Asp Lys Phe Lys Phe Val Phe Arg Glu Lys Met Gly 
385                 390                 395                 400 


Arg Ile Val Asp Tyr Phe Thr Ile Gln Asn Pro Ser Asn Val Asp His 
                405                 410                 415     


Tyr Ser Lys Leu Leu Phe Pro Leu Ile Phe Met Leu Ala Asn Val Phe 
            420                 425                 430         


Tyr Trp Ala Tyr Tyr Met Tyr Phe 
        435                 440 


<210>  5708
<211>  349
<212>  PRT
<213>  Homo Sapiens

<400>  5708

Met Asn Tyr Ser Leu His Leu Ala Phe Val Cys Leu Ser Leu Phe Thr 
1               5                   10                  15      


Glu Arg Met Cys Ile Gln Gly Ser Gln Phe Asn Val Glu Val Gly Arg 
            20                  25                  30          


Ser Asp Lys Leu Ser Leu Pro Gly Phe Glu Asn Leu Thr Ala Gly Tyr 
        35                  40                  45              


Asn Lys Phe Leu Arg Pro Asn Phe Gly Gly Glu Pro Val Gln Ile Ala 
    50                  55                  60                  


Leu Thr Leu Asp Ile Ala Ser Ile Ser Ser Ile Ser Glu Ser Asn Met 
65                  70                  75                  80  


Asp Tyr Thr Ala Thr Ile Tyr Leu Arg Gln Arg Trp Met Asp Gln Arg 
                85                  90                  95      


Leu Val Phe Glu Gly Asn Lys Ser Phe Thr Leu Asp Ala Arg Leu Val 
            100                 105                 110         


Glu Phe Leu Trp Val Pro Asp Thr Tyr Ile Val Glu Ser Lys Lys Ser 
        115                 120                 125             


Phe Leu His Glu Val Thr Val Gly Asn Arg Leu Ile Arg Leu Phe Ser 
    130                 135                 140                 


Asn Gly Thr Val Leu Tyr Ala Leu Arg Ile Thr Thr Thr Val Ala Cys 
145                 150                 155                 160 


Asn Met Asp Leu Ser Lys Tyr Pro Met Asp Thr Gln Thr Cys Lys Leu 
                165                 170                 175     


Gln Leu Glu Ser Trp Gly Tyr Asp Gly Asn Asp Val Glu Phe Thr Trp 
            180                 185                 190         


Leu Arg Gly Asn Asp Ser Val Arg Gly Leu Glu His Leu Arg Leu Ala 
        195                 200                 205             


Gln Tyr Thr Ile Glu Arg Tyr Phe Thr Leu Val Thr Arg Ser Gln Gln 
    210                 215                 220                 


Glu Thr Gly Asn Tyr Thr Arg Leu Val Leu Gln Phe Glu Leu Arg Arg 
225                 230                 235                 240 


Asn Val Leu Tyr Phe Ile Leu Glu Thr Tyr Val Pro Ser Thr Phe Leu 
                245                 250                 255     


Val Val Leu Ser Trp Val Ser Phe Trp Ile Ser Leu Asp Ser Val Pro 
            260                 265                 270         


Ala Arg Thr Cys Ile Gly Val Thr Thr Val Leu Ser Met Thr Thr Leu 
        275                 280                 285             


Met Ile Gly Ser Arg Thr Ser Leu Pro Asn Thr Asn Cys Phe Ile Lys 
    290                 295                 300                 


Ala Ile Asp Val Tyr Leu Gly Ile Cys Phe Ser Phe Val Phe Gly Ala 
305                 310                 315                 320 


Leu Leu Glu Tyr Ala Val Ala His Tyr Ser Ser Leu Gln Gln Met Ala 
                325                 330                 335     


Ala Lys Asp Arg Gln Lys Ile Cys Tyr Leu Tyr Ala Ala 
            340                 345                 


<210>  5709
<211>  289
<212>  PRT
<213>  Homo Sapiens

<400>  5709

Met Asn Tyr Ser Leu His Leu Ala Phe Val Cys Leu Ser Leu Phe Thr 
1               5                   10                  15      


Glu Arg Met Cys Ile Gln Gly Ser Gln Phe Asn Val Glu Val Gly Arg 
            20                  25                  30          


Ser Asp Lys Leu Ser Leu Pro Gly Phe Glu Asn Leu Thr Ala Gly Tyr 
        35                  40                  45              


Asn Lys Phe Leu Arg Pro Asn Phe Gly Gly Glu Pro Val Gln Ile Ala 
    50                  55                  60                  


Leu Thr Leu Asp Ile Ala Ser Ile Ser Ser Ile Ser Glu Ser Asn Met 
65                  70                  75                  80  


Asp Tyr Thr Ala Thr Ile Tyr Leu Arg Gln Arg Trp Met Asp Gln Arg 
                85                  90                  95      


Leu Val Phe Glu Gly Asn Lys Ser Phe Thr Leu Asp Ala Arg Leu Val 
            100                 105                 110         


Glu Phe Leu Trp Val Pro Asp Thr Tyr Ile Val Glu Ser Lys Lys Ser 
        115                 120                 125             


Phe Leu His Glu Val Thr Val Gly Asn Arg Leu Ile Arg Leu Phe Ser 
    130                 135                 140                 


Asn Gly Thr Val Leu Tyr Ala Leu Arg Ile Thr Thr Thr Val Ala Cys 
145                 150                 155                 160 


Asn Met Asp Leu Ser Lys Tyr Pro Met Asp Thr Gln Thr Cys Lys Leu 
                165                 170                 175     


Gln Leu Glu Ser Trp Gly Tyr Asp Gly Asn Asp Val Glu Phe Thr Trp 
            180                 185                 190         


Leu Arg Gly Asn Asp Ser Val Arg Gly Leu Glu His Leu Arg Leu Ala 
        195                 200                 205             


Gln Tyr Thr Ile Glu Arg Tyr Phe Thr Leu Val Thr Arg Ser Gln Gln 
    210                 215                 220                 


Glu Thr Gly Asn Tyr Thr Arg Leu Val Leu Gln Phe Glu Leu Arg Arg 
225                 230                 235                 240 


Asn Val Leu Tyr Phe Ile Leu Glu Thr Tyr Val Pro Ser Thr Phe Leu 
                245                 250                 255     


Val Val Leu Ser Trp Val Ser Phe Trp Ile Ser Leu Asp Ser Val Pro 
            260                 265                 270         


Ala Arg Thr Cys Ile Gly Asp Asn Lys Gly Ser Arg Arg Ser Gln Tyr 
        275                 280                 285             


Tyr 
    


<210>  5710
<211>  123
<212>  PRT
<213>  Homo Sapiens

<400>  5710

Met Ala Arg Gly Ser Ala Leu Leu Leu Ala Ser Leu Leu Leu Ala Ala 
1               5                   10                  15      


Ala Leu Ser Ala Ser Ala Gly Leu Trp Ser Pro Ala Lys Glu Lys Arg 
            20                  25                  30          


Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Pro His Ala Val 
        35                  40                  45              


Gly Asn His Arg Ser Phe Ser Asp Lys Asn Gly Leu Thr Ser Lys Arg 
    50                  55                  60                  


Glu Leu Arg Pro Glu Asp Asp Met Lys Pro Gly Ser Phe Asp Arg Ser 
65                  70                  75                  80  


Ile Pro Glu Asn Asn Ile Met Arg Thr Ile Ile Glu Phe Leu Ser Phe 
                85                  90                  95      


Leu His Leu Lys Glu Ala Gly Ala Leu Asp Arg Leu Leu Asp Leu Pro 
            100                 105                 110         


Ala Ala Ala Ser Ser Glu Asp Ile Glu Arg Ser 
        115                 120             


<210>  5711
<211>  113
<212>  PRT
<213>  Homo Sapiens

<400>  5711

Met Leu Pro Pro Gln Lys Lys Pro Trp Glu Ser Met Ala Lys Gly Leu 
1               5                   10                  15      


Val Leu Gly Ala Leu Phe Thr Ser Phe Leu Leu Leu Val Tyr Ser Tyr 
            20                  25                  30          


Ala Val Pro Pro Leu His Ala Gly Leu Ala Ser Thr Arg Thr Pro Glu 
        35                  40                  45              


Ala Ala Ala Ser Cys Ser Pro Pro Ala Leu Glu Pro Glu Ala Val Ile 
    50                  55                  60                  


Arg Ala Asn Gly Ser Ala Gly Glu Cys Gln Pro Arg Arg Asn Ile Val 
65                  70                  75                  80  


Phe Leu Lys Thr His Lys Thr Ala Ser Ser Thr Leu Leu Asn Ile Leu 
                85                  90                  95      


Phe Arg Phe Gly Gln Lys His Arg Leu Lys Phe Ala Phe Pro Asn Gly 
            100                 105                 110         


Arg 
    


<210>  5712
<211>  164
<212>  PRT
<213>  Homo Sapiens

<400>  5712

Met Leu Pro Pro Gln Lys Lys Pro Trp Glu Ser Met Ala Lys Gly Leu 
1               5                   10                  15      


Val Leu Gly Ala Leu Phe Thr Ser Phe Leu Leu Leu Val Tyr Ser Tyr 
            20                  25                  30          


Ala Val Pro Pro Leu His Ala Gly Leu Ala Ser Thr Arg Thr Pro Glu 
        35                  40                  45              


Ala Ala Ala Ser Cys Ser Pro Pro Ala Leu Glu Pro Glu Ala Val Ile 
    50                  55                  60                  


Arg Ala Asn Gly Ser Ala Gly Glu Cys Gln Pro Arg Arg Asn Ile Val 
65                  70                  75                  80  


Phe Leu Lys Thr His Lys Thr Ala Ser Ser Thr Leu Leu Asn Ile Leu 
                85                  90                  95      


Phe Arg Phe Gly Gln Lys His Arg Leu Lys Phe Ala Phe Pro Asn Gly 
            100                 105                 110         


Arg Asn Asp Phe Asp Tyr Pro Thr Phe Phe Ala Arg Ser Leu Val Gln 
        115                 120                 125             


Asp Tyr Arg Pro Gly Ala Cys Phe Asn Ile Ile Cys Asn His Met Arg 
    130                 135                 140                 


Phe His Tyr Asp Glu Val Arg Gly Leu Val Pro Thr Asn Ala Ile Phe 
145                 150                 155                 160 


Ile Thr Val Leu 
                


<210>  5713
<211>  265
<212>  PRT
<213>  Homo Sapiens

<400>  5713

Met Leu Pro Pro Gln Lys Lys Pro Trp Glu Ser Met Ala Lys Gly Leu 
1               5                   10                  15      


Val Leu Gly Ala Leu Phe Thr Ser Phe Leu Leu Leu Val Tyr Ser Tyr 
            20                  25                  30          


Ala Val Pro Pro Leu His Ala Gly Leu Ala Ser Thr Arg Thr Pro Glu 
        35                  40                  45              


Ala Ala Ala Ser Cys Ser Pro Pro Ala Leu Glu Pro Glu Ala Val Ile 
    50                  55                  60                  


Arg Ala Asn Gly Ser Ala Gly Glu Cys Gln Pro Arg Arg Asn Ile Val 
65                  70                  75                  80  


Phe Leu Lys Thr His Lys Thr Ala Ser Ser Thr Leu Leu Asn Ile Leu 
                85                  90                  95      


Phe Arg Phe Gly Gln Lys His Arg Leu Lys Phe Ala Phe Pro Asn Gly 
            100                 105                 110         


Arg Asn Asp Phe Asp Tyr Pro Thr Phe Phe Ala Arg Ser Leu Val Gln 
        115                 120                 125             


Asp Tyr Arg Pro Gly Ala Cys Phe Asn Ile Ile Cys Asn His Met Arg 
    130                 135                 140                 


Phe His Tyr Asp Glu Val Arg Gly Leu Val Pro Thr Asn Ala Ile Phe 
145                 150                 155                 160 


Ile Thr Val Leu Arg Asp Pro Ala Arg Leu Phe Glu Ser Ser Phe His 
                165                 170                 175     


Tyr Phe Gly Pro Val Val Pro Leu Thr Trp Lys Leu Ser Ala Gly Asp 
            180                 185                 190         


Lys Leu Thr Glu Phe Leu Gln Asp Pro Asp Arg Tyr Tyr Asp Pro Asn 
        195                 200                 205             


Gly Phe Asn Ala His Tyr Leu Arg Asn Leu Leu Phe Phe Asp Leu Gly 
    210                 215                 220                 


Tyr Asp Asn Ser Leu Asp Pro Ser Ser Pro Gln Val Gln Glu His Ile 
225                 230                 235                 240 


Leu Glu Val Glu Arg Arg Phe His Leu Val Leu Leu Gln Glu Tyr Phe 
                245                 250                 255     


Asp Glu Ser Leu Val Leu Leu Lys Asp 
            260                 265 


<210>  5714
<211>  71
<212>  PRT
<213>  Homo Sapiens

<400>  5714

Met Leu Pro Pro Gln Lys Lys Pro Trp Glu Ser Met Ala Lys Gly Leu 
1               5                   10                  15      


Val Leu Gly Ala Leu Phe Thr Ser Phe Leu Leu Leu Val Tyr Ser Tyr 
            20                  25                  30          


Ala Val Pro Pro Leu His Ala Gly Leu Ala Ser Thr Thr Pro Glu Ala 
        35                  40                  45              


Ala Ala Ser Cys Ser Pro Pro Ala Leu Glu Pro Glu Ala Val Ile Arg 
    50                  55                  60                  


Ala Asn Gly Ser Ala Gly Glu 
65                  70      


<210>  5715
<211>  76
<212>  PRT
<213>  Homo Sapiens

<400>  5715

Met Leu Pro Pro Gln Lys Lys Pro Trp Glu Ser Met Ala Lys Gly Leu 
1               5                   10                  15      


Val Leu Gly Ala Leu Phe Thr Ser Phe Leu Leu Leu Val Tyr Ser Tyr 
            20                  25                  30          


Ala Val Pro Pro Leu His Ala Gly Leu Ala Ser Thr Thr Pro Glu Ala 
        35                  40                  45              


Ala Ala Ser Cys Ser Pro Pro Ala Leu Glu Pro Glu Ala Val Ile Arg 
    50                  55                  60                  


Ala Asn Gly Ser Ala Gly Glu Cys Gln Pro Arg Arg 
65                  70                  75      


<210>  5716
<211>  85
<212>  PRT
<213>  Homo Sapiens

<400>  5716

Met Leu Pro Pro Gln Lys Lys Pro Trp Glu Ser Met Ala Lys Gly Leu 
1               5                   10                  15      


Val Leu Gly Ala Leu Phe Thr Ser Phe Leu Leu Leu Val Tyr Ser Tyr 
            20                  25                  30          


Ala Val Pro Pro Leu His Ala Gly Leu Ala Ser Thr Thr Pro Glu Ala 
        35                  40                  45              


Ala Ala Ser Cys Ser Pro Pro Ala Leu Glu Pro Glu Ala Val Ile Arg 
    50                  55                  60                  


Ala Asn Gly Ser Ala Gly Glu Cys Gln Pro Arg Arg Asn Ile Val Phe 
65                  70                  75                  80  


Leu Lys Thr His Lys 
                85  


<210>  5717
<211>  95
<212>  PRT
<213>  Homo Sapiens

<400>  5717

Met Leu Pro Pro Gln Lys Lys Pro Trp Glu Ser Met Ala Lys Gly Leu 
1               5                   10                  15      


Val Leu Gly Ala Leu Phe Thr Ser Phe Leu Leu Leu Val Tyr Ser Tyr 
            20                  25                  30          


Ala Val Pro Pro Leu His Ala Gly Leu Ala Ser Thr Thr Pro Glu Ala 
        35                  40                  45              


Ala Ala Ser Cys Ser Pro Pro Ala Leu Glu Pro Glu Ala Val Ile Arg 
    50                  55                  60                  


Ala Asn Gly Ser Ala Gly Glu Cys Gln Pro Arg Arg Asn Ile Val Phe 
65                  70                  75                  80  


Leu Lys Thr His Lys Thr Ala Ser Ser Thr Leu Leu Asn Ile Leu 
                85                  90                  95  


<210>  5718
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  5718

Met Leu Pro Pro Gln Lys Lys Pro Trp Glu Ser Met Ala Lys Gly Leu 
1               5                   10                  15      


Val Leu Gly Ala Leu Phe Thr Ser Phe Leu Leu Leu Val Tyr Ser Tyr 
            20                  25                  30          


Ala Val Pro Pro Leu His Ala Gly Leu Ala Ser Thr Thr Pro Glu Ala 
        35                  40                  45              


Ala Ala Ser Cys Ser Pro Pro Ala Leu Glu Pro Glu Ala Val Ile Arg 
    50                  55                  60                  


Ala Asn Gly Ser Ala Gly Glu Cys Gln Pro Arg Arg Asn Ile Val Phe 
65                  70                  75                  80  


Leu Lys Thr His Lys Thr Ala Ser Ser Thr Leu Leu Asn Ile Leu Phe 
                85                  90                  95      


Arg Phe Gly 
            


<210>  5719
<211>  100
<212>  PRT
<213>  Homo Sapiens

<400>  5719

Met Leu Pro Pro Gln Lys Lys Pro Trp Glu Ser Met Ala Lys Gly Leu 
1               5                   10                  15      


Val Leu Gly Ala Leu Phe Thr Ser Phe Leu Leu Leu Val Tyr Ser Tyr 
            20                  25                  30          


Ala Val Pro Pro Leu His Ala Gly Leu Ala Ser Thr Thr Pro Glu Ala 
        35                  40                  45              


Ala Ala Ser Cys Ser Pro Pro Ala Leu Glu Pro Glu Ala Val Ile Arg 
    50                  55                  60                  


Ala Asn Gly Ser Ala Gly Glu Cys Gln Pro Arg Arg Asn Ile Val Phe 
65                  70                  75                  80  


Leu Lys Thr His Lys Thr Ala Ser Ser Thr Leu Leu Asn Ile Leu Phe 
                85                  90                  95      


Arg Phe Gly Gln 
            100 


<210>  5720
<211>  103
<212>  PRT
<213>  Homo Sapiens

<400>  5720

Met Leu Pro Pro Gln Lys Lys Pro Trp Glu Ser Met Ala Lys Gly Leu 
1               5                   10                  15      


Val Leu Gly Ala Leu Phe Thr Ser Phe Leu Leu Leu Val Tyr Ser Tyr 
            20                  25                  30          


Ala Val Pro Pro Leu His Ala Gly Leu Ala Ser Thr Thr Pro Glu Ala 
        35                  40                  45              


Ala Ala Ser Cys Ser Pro Pro Ala Leu Glu Pro Glu Ala Val Ile Arg 
    50                  55                  60                  


Ala Asn Gly Ser Ala Gly Glu Cys Gln Pro Arg Arg Asn Ile Val Phe 
65                  70                  75                  80  


Leu Lys Thr His Lys Thr Ala Ser Ser Thr Leu Leu Asn Ile Leu Phe 
                85                  90                  95      


Arg Phe Gly Gln Lys His Arg 
            100             


<210>  5721
<211>  143
<212>  PRT
<213>  Homo Sapiens

<400>  5721

Met Leu Pro Pro Gln Lys Lys Pro Trp Glu Ser Met Ala Lys Gly Leu 
1               5                   10                  15      


Val Leu Gly Ala Leu Phe Thr Ser Phe Leu Leu Leu Val Tyr Ser Tyr 
            20                  25                  30          


Ala Val Pro Pro Leu His Ala Gly Leu Ala Ser Thr Thr Pro Glu Ala 
        35                  40                  45              


Ala Ala Ser Cys Ser Pro Pro Ala Leu Glu Pro Glu Ala Val Ile Arg 
    50                  55                  60                  


Ala Asn Gly Ser Ala Gly Glu Cys Gln Pro Arg Arg Asn Ile Val Phe 
65                  70                  75                  80  


Leu Lys Thr His Lys Thr Ala Ser Ser Thr Leu Leu Asn Ile Leu Phe 
                85                  90                  95      


Arg Phe Gly Gln Lys His Arg Leu Lys Phe Ala Phe Pro Asn Gly Arg 
            100                 105                 110         


Asn Asp Phe Asp Tyr Pro Thr Phe Phe Ala Arg Ser Leu Val Gln Asp 
        115                 120                 125             


Tyr Arg Pro Gly Ala Cys Phe Asn Ile Ile Cys Asn His Met Arg 
    130                 135                 140             


<210>  5722
<211>  149
<212>  PRT
<213>  Homo Sapiens

<400>  5722

Met Leu Pro Pro Gln Lys Lys Pro Trp Glu Ser Met Ala Lys Gly Leu 
1               5                   10                  15      


Val Leu Gly Ala Leu Phe Thr Ser Phe Leu Leu Leu Val Tyr Ser Tyr 
            20                  25                  30          


Ala Val Pro Pro Leu His Ala Gly Leu Ala Ser Thr Thr Pro Glu Ala 
        35                  40                  45              


Ala Ala Ser Cys Ser Pro Pro Ala Leu Glu Pro Glu Ala Val Ile Arg 
    50                  55                  60                  


Ala Asn Gly Ser Ala Gly Glu Cys Gln Pro Arg Arg Asn Ile Val Phe 
65                  70                  75                  80  


Leu Lys Thr His Lys Thr Ala Ser Ser Thr Leu Leu Asn Ile Leu Phe 
                85                  90                  95      


Arg Phe Gly Gln Lys His Arg Leu Lys Phe Ala Phe Pro Asn Gly Arg 
            100                 105                 110         


Asn Asp Phe Asp Tyr Pro Thr Phe Phe Ala Arg Ser Leu Val Gln Asp 
        115                 120                 125             


Tyr Arg Pro Gly Ala Cys Phe Asn Ile Ile Cys Asn His Met Arg Phe 
    130                 135                 140                 


His Tyr Asp Glu Val 
145                 


<210>  5723
<211>  170
<212>  PRT
<213>  Homo Sapiens

<400>  5723

Met Leu Pro Pro Gln Lys Lys Pro Trp Glu Ser Met Ala Lys Gly Leu 
1               5                   10                  15      


Val Leu Gly Ala Leu Phe Thr Ser Phe Leu Leu Leu Val Tyr Ser Tyr 
            20                  25                  30          


Ala Val Pro Pro Leu His Ala Gly Leu Ala Ser Thr Thr Pro Glu Ala 
        35                  40                  45              


Ala Ala Ser Cys Ser Pro Pro Ala Leu Glu Pro Glu Ala Val Ile Arg 
    50                  55                  60                  


Ala Asn Gly Ser Ala Gly Glu Cys Gln Pro Arg Arg Asn Ile Val Phe 
65                  70                  75                  80  


Leu Lys Thr His Lys Thr Ala Ser Ser Thr Leu Leu Asn Ile Leu Phe 
                85                  90                  95      


Arg Phe Gly Gln Lys His Arg Leu Lys Phe Ala Phe Pro Asn Gly Arg 
            100                 105                 110         


Asn Asp Phe Asp Tyr Pro Thr Phe Phe Ala Arg Ser Leu Val Gln Asp 
        115                 120                 125             


Tyr Arg Pro Gly Ala Cys Phe Asn Ile Ile Cys Asn His Met Arg Phe 
    130                 135                 140                 


His Tyr Asp Glu Val Arg Gly Leu Val Pro Thr Asn Ala Ile Phe Ile 
145                 150                 155                 160 


Thr Val Leu Arg Asp Pro Ala Arg Leu Phe 
                165                 170 


<210>  5724
<211>  199
<212>  PRT
<213>  Homo Sapiens

<400>  5724

Met Leu Pro Pro Gln Lys Lys Pro Trp Glu Ser Met Ala Lys Gly Leu 
1               5                   10                  15      


Val Leu Gly Ala Leu Phe Thr Ser Phe Leu Leu Leu Val Tyr Ser Tyr 
            20                  25                  30          


Ala Val Pro Pro Leu His Ala Gly Leu Ala Ser Thr Thr Pro Glu Ala 
        35                  40                  45              


Ala Ala Ser Cys Ser Pro Pro Ala Leu Glu Pro Glu Ala Val Ile Arg 
    50                  55                  60                  


Ala Asn Gly Ser Ala Gly Glu Cys Gln Pro Arg Arg Asn Ile Val Phe 
65                  70                  75                  80  


Leu Lys Thr His Lys Thr Ala Ser Ser Thr Leu Leu Asn Ile Leu Phe 
                85                  90                  95      


Arg Phe Gly Gln Lys His Arg Leu Lys Phe Ala Phe Pro Asn Gly Arg 
            100                 105                 110         


Asn Asp Phe Asp Tyr Pro Thr Phe Phe Ala Arg Ser Leu Val Gln Asp 
        115                 120                 125             


Tyr Arg Pro Gly Ala Cys Phe Asn Ile Ile Cys Asn His Met Arg Phe 
    130                 135                 140                 


His Tyr Asp Glu Val Arg Gly Leu Val Pro Thr Asn Ala Ile Phe Ile 
145                 150                 155                 160 


Thr Val Leu Arg Asp Pro Ala Arg Leu Phe Glu Ser Ser Phe His Tyr 
                165                 170                 175     


Phe Gly Pro Val Val Pro Leu Thr Trp Lys Leu Ser Ala Gly Asp Lys 
            180                 185                 190         


Leu Thr Glu Phe Leu Gln Asp 
        195                 


<210>  5725
<211>  242
<212>  PRT
<213>  Homo Sapiens

<400>  5725

Met Leu Pro Pro Gln Lys Lys Pro Trp Glu Ser Met Ala Lys Gly Leu 
1               5                   10                  15      


Val Leu Gly Ala Leu Phe Thr Ser Phe Leu Leu Leu Val Tyr Ser Tyr 
            20                  25                  30          


Ala Val Pro Pro Leu His Ala Gly Leu Ala Ser Thr Thr Pro Glu Ala 
        35                  40                  45              


Ala Ala Ser Cys Ser Pro Pro Ala Leu Glu Pro Glu Ala Val Ile Arg 
    50                  55                  60                  


Ala Asn Gly Ser Ala Gly Glu Cys Gln Pro Arg Arg Asn Ile Val Phe 
65                  70                  75                  80  


Leu Lys Thr His Lys Thr Ala Ser Ser Thr Leu Leu Asn Ile Leu Phe 
                85                  90                  95      


Arg Phe Gly Gln Lys His Arg Leu Lys Phe Ala Phe Pro Asn Gly Arg 
            100                 105                 110         


Asn Asp Phe Asp Tyr Pro Thr Phe Phe Ala Arg Ser Leu Val Gln Asp 
        115                 120                 125             


Tyr Arg Pro Gly Ala Cys Phe Asn Ile Ile Cys Asn His Met Arg Phe 
    130                 135                 140                 


His Tyr Asp Glu Val Arg Gly Leu Val Pro Thr Asn Ala Ile Phe Ile 
145                 150                 155                 160 


Thr Val Leu Arg Asp Pro Ala Arg Leu Phe Glu Ser Ser Phe His Tyr 
                165                 170                 175     


Phe Gly Pro Val Val Pro Leu Thr Trp Lys Leu Ser Ala Gly Asp Lys 
            180                 185                 190         


Leu Thr Glu Phe Leu Gln Asp Pro Asp Arg Tyr Tyr Asp Pro Asn Gly 
        195                 200                 205             


Phe Asn Ala His Tyr Leu Arg Asn Leu Leu Phe Phe Asp Leu Gly Tyr 
    210                 215                 220                 


Asp Asn Ser Leu Asp Pro Ser Ser Pro Gln Val Gln Glu His Ile Leu 
225                 230                 235                 240 


Glu Val 
        


<210>  5726
<211>  423
<212>  PRT
<213>  Homo Sapiens

<400>  5726

Met Leu Pro Pro Gln Lys Lys Pro Trp Glu Ser Met Ala Lys Gly Leu 
1               5                   10                  15      


Val Leu Gly Ala Leu Phe Thr Ser Phe Leu Leu Leu Val Tyr Ser Tyr 
            20                  25                  30          


Ala Val Pro Pro Leu His Ala Gly Leu Ala Ser Thr Thr Pro Glu Ala 
        35                  40                  45              


Ala Ala Ser Cys Ser Pro Pro Ala Leu Glu Pro Glu Ala Val Ile Arg 
    50                  55                  60                  


Ala Asn Gly Ser Ala Gly Glu Cys Gln Pro Arg Arg Asn Ile Val Phe 
65                  70                  75                  80  


Leu Lys Thr His Lys Thr Ala Ser Ser Thr Leu Leu Asn Ile Leu Phe 
                85                  90                  95      


Arg Phe Gly Gln Lys His Arg Leu Lys Phe Ala Phe Pro Asn Gly Arg 
            100                 105                 110         


Asn Asp Phe Asp Tyr Pro Thr Phe Phe Ala Arg Ser Leu Val Gln Asp 
        115                 120                 125             


Tyr Arg Pro Gly Ala Cys Phe Asn Ile Ile Cys Asn His Met Arg Phe 
    130                 135                 140                 


His Tyr Asp Glu Val Arg Gly Leu Val Pro Thr Asn Ala Ile Phe Ile 
145                 150                 155                 160 


Thr Val Leu Arg Asp Pro Ala Arg Leu Phe Glu Ser Ser Phe His Tyr 
                165                 170                 175     


Phe Gly Pro Val Val Pro Leu Thr Trp Lys Leu Ser Ala Gly Asp Lys 
            180                 185                 190         


Leu Thr Glu Phe Leu Gln Asp Pro Asp Arg Tyr Tyr Asp Pro Asn Gly 
        195                 200                 205             


Phe Asn Ala His Tyr Leu Arg Asn Leu Leu Phe Phe Asp Leu Gly Tyr 
    210                 215                 220                 


Asp Asn Ser Leu Asp Pro Ser Ser Pro Gln Val Gln Glu His Ile Leu 
225                 230                 235                 240 


Glu Val Glu Arg Arg Phe His Leu Val Leu Leu Gln Glu Tyr Phe Asp 
                245                 250                 255     


Glu Ser Leu Val Leu Leu Lys Asp Leu Leu Cys Trp Glu Leu Glu Asp 
            260                 265                 270         


Val Leu Tyr Phe Lys Leu Asn Ala Arg Arg Asp Ser Pro Val Pro Arg 
        275                 280                 285             


Leu Ser Gly Glu Leu Tyr Gly Arg Ala Thr Ala Trp Asn Met Leu Asp 
    290                 295                 300                 


Ser His Leu Tyr Arg His Phe Asn Ala Ser Phe Trp Arg Lys Val Glu 
305                 310                 315                 320 


Ala Phe Gly Arg Glu Arg Met Ala Arg Glu Val Ala Ala Leu Arg His 
                325                 330                 335     


Ala Asn Glu Arg Met Arg Thr Ile Cys Ile Asp Gly Gly His Ala Val 
            340                 345                 350         


Asp Ala Ala Ala Ile Gln Asp Glu Ala Met Gln Pro Trp Gln Pro Leu 
        355                 360                 365             


Gly Thr Lys Ser Ile Leu Gly Tyr Asn Leu Lys Lys Ser Ile Gly Gln 
    370                 375                 380                 


Arg His Ala Gln Leu Cys Arg Arg Met Leu Thr Pro Glu Ile Gln Tyr 
385                 390                 395                 400 


Leu Met Asp Leu Gly Ala Asn Leu Trp Val Thr Lys Leu Trp Lys Phe 
                405                 410                 415     


Ile Arg Asp Phe Leu Arg Trp 
            420             


<210>  5727
<211>  279
<212>  PRT
<213>  Homo Sapiens

<400>  5727

Met Leu Pro Pro Gln Lys Lys Pro Trp Glu Ser Met Ala Lys Gly Leu 
1               5                   10                  15      


Val Leu Gly Ala Leu Phe Thr Ser Phe Leu Leu Leu Val Tyr Ser Tyr 
            20                  25                  30          


Ala Val Pro Pro Leu His Ala Gly Leu Ala Ser Thr Thr Pro Glu Ala 
        35                  40                  45              


Ala Ala Ser Cys Ser Pro Pro Ala Leu Glu Pro Glu Ala Val Ile Arg 
    50                  55                  60                  


Ala Asn Gly Ser Ala Gly Glu Cys Gln Pro Arg Arg Asn Ile Val Phe 
65                  70                  75                  80  


Leu Lys Thr His Lys Thr Ala Ser Ser Thr Leu Leu Asn Ile Leu Phe 
                85                  90                  95      


Arg Phe Gly Gln Lys His Arg Leu Lys Phe Ala Phe Pro Asn Gly Arg 
            100                 105                 110         


Asn Asp Phe Asp Tyr Pro Thr Phe Phe Ala Arg Ser Leu Val Gln Asp 
        115                 120                 125             


Tyr Arg Pro Gly Ala Cys Phe Asn Ile Ile Cys Asn His Met Arg Phe 
    130                 135                 140                 


His Tyr Asp Glu Val Arg Gly Leu Val Pro Thr Asn Ala Ile Phe Ile 
145                 150                 155                 160 


Thr Val Leu Arg Asp Pro Ala Arg Leu Phe Glu Ser Ser Phe His Tyr 
                165                 170                 175     


Phe Gly Pro Val Val Pro Leu Thr Trp Lys Leu Ser Ala Gly Asp Lys 
            180                 185                 190         


Leu Thr Glu Phe Leu Gln Asp Pro Asp Arg Tyr Tyr Asp Pro Asn Gly 
        195                 200                 205             


Phe Asn Ala His Tyr Leu Arg Asn Leu Leu Phe Phe Asp Leu Gly Tyr 
    210                 215                 220                 


Asp Asn Ser Leu Asp Pro Ser Ser Pro Gln Val Gln Glu His Ile Leu 
225                 230                 235                 240 


Glu Val Glu Arg Arg Phe His Leu Val Leu Leu Gln Glu Tyr Phe Asp 
                245                 250                 255     


Glu Ser Leu Val Leu Leu Lys Asp Leu Leu Cys Trp Glu Leu Glu Asp 
            260                 265                 270         


Val Leu Tyr Phe Lys Leu Asn 
        275                 


<210>  5728
<211>  423
<212>  PRT
<213>  Homo Sapiens

<400>  5728

Met Leu Pro Pro Gln Lys Lys Pro Trp Glu Ser Met Ala Lys Gly Leu 
1               5                   10                  15      


Val Leu Gly Ala Leu Phe Thr Ser Phe Leu Leu Leu Val Tyr Ser Tyr 
            20                  25                  30          


Ala Val Pro Pro Leu His Ala Gly Leu Ala Ser Thr Thr Pro Glu Ala 
        35                  40                  45              


Ala Ala Ser Cys Ser Pro Pro Ala Leu Glu Pro Glu Ala Val Ile Arg 
    50                  55                  60                  


Ala Asn Gly Ser Ala Gly Glu Cys Gln Pro Arg Arg Asn Ile Val Phe 
65                  70                  75                  80  


Leu Lys Thr His Lys Thr Ala Ser Ser Thr Leu Leu Asn Ile Leu Phe 
                85                  90                  95      


Arg Phe Gly Gln Lys His Arg Leu Lys Phe Ala Phe Pro Asn Gly Arg 
            100                 105                 110         


Asn Asp Phe Asp Tyr Pro Thr Phe Phe Ala Arg Ser Leu Val Gln Asp 
        115                 120                 125             


Tyr Arg Pro Gly Ala Cys Phe Asn Ile Ile Cys Asn His Met Arg Phe 
    130                 135                 140                 


His Tyr Asp Glu Val Arg Gly Leu Val Pro Thr Asn Ala Ile Phe Ile 
145                 150                 155                 160 


Thr Val Leu Arg Asp Pro Ala Arg Leu Phe Glu Ser Ser Phe His Tyr 
                165                 170                 175     


Phe Gly Pro Val Val Pro Leu Thr Trp Lys Leu Ser Ala Gly Asp Lys 
            180                 185                 190         


Leu Thr Glu Phe Leu Gln Asp Pro Asp Arg Tyr Tyr Asp Pro Asn Gly 
        195                 200                 205             


Phe Asn Ala His Tyr Leu Arg Asn Leu Leu Phe Phe Asp Leu Gly Tyr 
    210                 215                 220                 


Asp Asn Ser Leu Asp Pro Ser Ser Pro Gln Val Gln Glu His Ile Leu 
225                 230                 235                 240 


Glu Val Glu Arg Arg Phe His Leu Val Leu Leu Gln Glu Tyr Phe Asp 
                245                 250                 255     


Glu Ser Leu Val Leu Leu Lys Asp Leu Leu Cys Trp Glu Leu Glu Asp 
            260                 265                 270         


Val Leu Tyr Phe Lys Leu Asn Ala Arg Arg Asp Ser Pro Val Pro Arg 
        275                 280                 285             


Leu Ser Gly Glu Leu Tyr Gly Arg Ala Thr Ala Trp Asn Met Leu Asp 
    290                 295                 300                 


Ser His Leu Tyr Arg His Phe Asn Ala Ser Phe Trp Arg Lys Val Glu 
305                 310                 315                 320 


Ala Phe Gly Arg Glu Arg Met Ala Arg Glu Val Ala Ala Leu Arg His 
                325                 330                 335     


Ala Asn Glu Arg Met Arg Thr Ile Cys Ile Asp Gly Gly His Ala Val 
            340                 345                 350         


Asp Ala Ala Ala Ile Gln Asp Glu Ala Met Gln Pro Trp Gln Pro Leu 
        355                 360                 365             


Gly Thr Lys Ser Ile Leu Gly Tyr Asn Leu Lys Lys Ser Ile Gly Gln 
    370                 375                 380                 


Arg His Ala Gln Leu Cys Arg Arg Met Leu Thr Pro Glu Ile Gln Tyr 
385                 390                 395                 400 


Leu Met Asp Leu Gly Ala Asn Leu Trp Val Thr Lys Leu Trp Lys Phe 
                405                 410                 415     


Ile Arg Asp Phe Leu Arg Trp 
            420             


<210>  5729
<211>  423
<212>  PRT
<213>  Homo Sapiens

<400>  5729

Met Leu Pro Pro Gln Lys Lys Pro Trp Glu Ser Met Ala Lys Gly Leu 
1               5                   10                  15      


Val Leu Gly Ala Leu Phe Thr Ser Phe Leu Leu Leu Val Tyr Ser Tyr 
            20                  25                  30          


Ala Val Pro Pro Leu His Ala Gly Leu Ala Ser Thr Thr Pro Glu Ala 
        35                  40                  45              


Ala Ala Ser Cys Ser Pro Pro Ala Leu Glu Pro Glu Ala Val Ile Arg 
    50                  55                  60                  


Ala Asn Gly Ser Ala Gly Glu Cys Gln Pro Arg Arg Asn Ile Val Phe 
65                  70                  75                  80  


Leu Lys Thr His Lys Thr Ala Ser Ser Thr Leu Leu Asn Ile Leu Phe 
                85                  90                  95      


Arg Phe Gly Gln Lys His Arg Leu Lys Phe Ala Phe Pro Asn Gly Arg 
            100                 105                 110         


Asn Asp Phe Asp Tyr Pro Thr Phe Phe Ala Arg Ser Leu Val Gln Asp 
        115                 120                 125             


Tyr Arg Pro Gly Ala Cys Phe Asn Ile Ile Cys Asn His Met Arg Phe 
    130                 135                 140                 


His Tyr Asp Glu Val Arg Gly Leu Val Pro Thr Asn Ala Ile Phe Ile 
145                 150                 155                 160 


Thr Val Leu Arg Asp Pro Ala Arg Leu Phe Glu Ser Ser Phe His Tyr 
                165                 170                 175     


Phe Gly Pro Val Val Pro Leu Thr Trp Lys Leu Ser Ala Gly Asp Lys 
            180                 185                 190         


Leu Thr Glu Phe Leu Gln Asp Pro Asp Arg Tyr Tyr Asp Pro Asn Gly 
        195                 200                 205             


Phe Asn Ala His Tyr Leu Arg Asn Leu Leu Phe Phe Asp Leu Gly Tyr 
    210                 215                 220                 


Asp Asn Ser Leu Asp Pro Ser Ser Pro Gln Val Gln Glu His Ile Leu 
225                 230                 235                 240 


Glu Val Glu Arg Arg Phe His Leu Val Leu Leu Gln Glu Tyr Phe Asp 
                245                 250                 255     


Glu Ser Leu Val Leu Leu Lys Asp Leu Leu Cys Trp Glu Leu Glu Asp 
            260                 265                 270         


Val Leu Tyr Phe Lys Leu Asn Ala Arg Arg Asp Ser Pro Val Pro Arg 
        275                 280                 285             


Leu Ser Gly Glu Leu Tyr Gly Arg Ala Thr Ala Trp Asn Met Leu Asp 
    290                 295                 300                 


Ser His Leu Tyr Arg His Phe Asn Ala Ser Phe Trp Arg Lys Val Glu 
305                 310                 315                 320 


Ala Phe Gly Arg Glu Arg Met Ala Arg Glu Val Ala Ala Leu Arg His 
                325                 330                 335     


Ala Asn Glu Arg Met Arg Thr Ile Cys Ile Asp Gly Gly His Ala Val 
            340                 345                 350         


Asp Ala Ala Ala Ile Gln Asp Glu Ala Met Gln Pro Trp Gln Pro Leu 
        355                 360                 365             


Gly Thr Lys Ser Ile Leu Gly Tyr Asn Leu Lys Lys Ser Ile Gly Gln 
    370                 375                 380                 


Arg His Ala Gln Leu Cys Arg Arg Met Leu Thr Pro Glu Ile Gln Tyr 
385                 390                 395                 400 


Leu Met Asp Leu Gly Ala Asn Leu Trp Val Thr Lys Leu Trp Lys Phe 
                405                 410                 415     


Ile Arg Asp Phe Leu Arg Trp 
            420             


<210>  5730
<211>  423
<212>  PRT
<213>  Homo Sapiens

<400>  5730

Met Leu Pro Pro Gln Lys Lys Pro Trp Glu Ser Met Ala Lys Gly Leu 
1               5                   10                  15      


Val Leu Gly Ala Leu Phe Thr Ser Phe Leu Leu Leu Val Tyr Ser Tyr 
            20                  25                  30          


Ala Val Pro Pro Leu His Ala Gly Leu Ala Ser Thr Thr Pro Glu Ala 
        35                  40                  45              


Ala Ala Ser Cys Ser Pro Pro Ala Leu Glu Pro Glu Ala Val Ile Arg 
    50                  55                  60                  


Ala Asn Gly Ser Ala Gly Glu Cys Gln Pro Arg Arg Asn Ile Val Phe 
65                  70                  75                  80  


Leu Lys Thr His Lys Thr Ala Ser Ser Thr Leu Leu Asn Ile Leu Phe 
                85                  90                  95      


Arg Phe Gly Gln Lys His Arg Leu Lys Phe Ala Phe Pro Asn Gly Arg 
            100                 105                 110         


Asn Asp Phe Asp Tyr Pro Thr Phe Phe Ala Arg Ser Leu Val Gln Asp 
        115                 120                 125             


Tyr Arg Pro Gly Ala Cys Phe Asn Ile Ile Cys Asn His Met Arg Phe 
    130                 135                 140                 


His Tyr Asp Glu Val Arg Gly Leu Val Pro Thr Asn Ala Ile Phe Ile 
145                 150                 155                 160 


Thr Val Leu Arg Asp Pro Ala Arg Leu Phe Glu Ser Ser Phe His Tyr 
                165                 170                 175     


Phe Gly Pro Val Val Pro Leu Thr Trp Lys Leu Ser Ala Gly Asp Lys 
            180                 185                 190         


Leu Thr Glu Phe Leu Gln Asp Pro Asp Arg Tyr Tyr Asp Pro Asn Gly 
        195                 200                 205             


Phe Asn Ala His Tyr Leu Arg Asn Leu Leu Phe Phe Asp Leu Gly Tyr 
    210                 215                 220                 


Asp Asn Ser Leu Asp Pro Ser Ser Pro Gln Val Gln Glu His Ile Leu 
225                 230                 235                 240 


Glu Val Glu Arg Arg Phe His Leu Val Leu Leu Gln Glu Tyr Phe Asp 
                245                 250                 255     


Glu Ser Leu Val Leu Leu Lys Asp Leu Leu Cys Trp Glu Leu Glu Asp 
            260                 265                 270         


Val Leu Tyr Phe Lys Leu Asn Ala Arg Arg Asp Ser Pro Val Pro Arg 
        275                 280                 285             


Leu Ser Gly Glu Leu Tyr Gly Arg Ala Thr Ala Trp Asn Met Leu Asp 
    290                 295                 300                 


Ser His Leu Tyr Arg His Phe Asn Ala Ser Phe Trp Arg Lys Val Glu 
305                 310                 315                 320 


Ala Phe Gly Arg Glu Arg Met Ala Arg Glu Val Ala Ala Leu Arg His 
                325                 330                 335     


Ala Asn Glu Arg Met Arg Thr Ile Cys Ile Asp Gly Gly His Ala Val 
            340                 345                 350         


Asp Ala Ala Ala Ile Gln Asp Glu Ala Met Gln Pro Trp Gln Pro Leu 
        355                 360                 365             


Gly Thr Lys Ser Ile Leu Gly Tyr Asn Leu Lys Lys Ser Ile Gly Gln 
    370                 375                 380                 


Arg His Ala Gln Leu Cys Arg Arg Met Leu Thr Pro Glu Ile Gln Tyr 
385                 390                 395                 400 


Leu Met Asp Leu Gly Ala Asn Leu Trp Val Thr Lys Leu Trp Lys Phe 
                405                 410                 415     


Ile Arg Asp Phe Leu Arg Trp 
            420             


<210>  5731
<211>  423
<212>  PRT
<213>  Homo Sapiens

<400>  5731

Met Leu Pro Pro Gln Lys Lys Pro Trp Glu Ser Met Ala Lys Gly Leu 
1               5                   10                  15      


Val Leu Gly Ala Leu Phe Thr Ser Phe Leu Leu Leu Val Tyr Ser Tyr 
            20                  25                  30          


Ala Val Pro Pro Leu His Ala Gly Leu Ala Ser Thr Thr Pro Glu Ala 
        35                  40                  45              


Ala Ala Ser Cys Ser Pro Pro Ala Leu Glu Pro Glu Ala Val Ile Arg 
    50                  55                  60                  


Ala Asn Gly Ser Ala Gly Glu Cys Gln Pro Arg Arg Asn Ile Val Phe 
65                  70                  75                  80  


Leu Lys Thr His Lys Thr Ala Ser Ser Thr Leu Leu Asn Ile Leu Phe 
                85                  90                  95      


Arg Phe Gly Gln Lys His Arg Leu Lys Phe Ala Phe Pro Asn Gly Arg 
            100                 105                 110         


Asn Asp Phe Asp Tyr Pro Thr Phe Phe Ala Arg Ser Leu Val Gln Asp 
        115                 120                 125             


Tyr Arg Pro Gly Ala Cys Phe Asn Ile Ile Cys Asn His Met Arg Phe 
    130                 135                 140                 


His Tyr Asp Glu Val Arg Gly Leu Val Pro Thr Asn Ala Ile Phe Ile 
145                 150                 155                 160 


Thr Val Leu Arg Asp Pro Ala Arg Leu Phe Glu Ser Ser Phe His Tyr 
                165                 170                 175     


Phe Gly Pro Val Val Pro Leu Thr Trp Lys Leu Ser Ala Gly Asp Lys 
            180                 185                 190         


Leu Thr Glu Phe Leu Gln Asp Pro Asp Arg Tyr Tyr Asp Pro Asn Gly 
        195                 200                 205             


Phe Asn Ala His Tyr Leu Arg Asn Leu Leu Phe Phe Asp Leu Gly Tyr 
    210                 215                 220                 


Asp Asn Ser Leu Asp Pro Ser Ser Pro Gln Val Gln Glu His Ile Leu 
225                 230                 235                 240 


Glu Val Glu Arg Arg Phe His Leu Val Leu Leu Gln Glu Tyr Phe Asp 
                245                 250                 255     


Glu Ser Leu Val Leu Leu Lys Asp Leu Leu Cys Trp Glu Leu Glu Asp 
            260                 265                 270         


Val Leu Tyr Phe Lys Leu Asn Ala Arg Arg Asp Ser Pro Val Pro Arg 
        275                 280                 285             


Leu Ser Gly Glu Leu Tyr Gly Arg Ala Thr Ala Trp Asn Met Leu Asp 
    290                 295                 300                 


Ser His Leu Tyr Arg His Phe Asn Ala Ser Phe Trp Arg Lys Val Glu 
305                 310                 315                 320 


Ala Phe Gly Arg Glu Arg Met Ala Arg Glu Val Ala Ala Leu Arg His 
                325                 330                 335     


Ala Asn Glu Arg Met Arg Thr Ile Cys Ile Asp Gly Gly His Ala Val 
            340                 345                 350         


Asp Ala Ala Ala Ile Gln Asp Glu Ala Met Gln Pro Trp Gln Pro Leu 
        355                 360                 365             


Gly Thr Lys Ser Ile Leu Gly Tyr Asn Leu Lys Lys Ser Ile Gly Gln 
    370                 375                 380                 


Arg His Ala Gln Leu Cys Arg Arg Met Leu Thr Pro Glu Ile Gln Tyr 
385                 390                 395                 400 


Leu Met Asp Leu Gly Ala Asn Leu Trp Val Thr Lys Leu Trp Lys Phe 
                405                 410                 415     


Ile Arg Asp Phe Leu Arg Trp 
            420             


<210>  5732
<211>  423
<212>  PRT
<213>  Homo Sapiens

<400>  5732

Met Leu Pro Pro Gln Lys Lys Pro Trp Glu Ser Met Ala Lys Gly Leu 
1               5                   10                  15      


Val Leu Gly Ala Leu Phe Thr Ser Phe Leu Leu Leu Val Tyr Ser Tyr 
            20                  25                  30          


Ala Val Pro Pro Leu His Ala Gly Leu Ala Ser Thr Thr Pro Glu Ala 
        35                  40                  45              


Ala Ala Ser Cys Ser Pro Pro Ala Leu Glu Pro Glu Ala Val Ile Arg 
    50                  55                  60                  


Ala Asn Gly Ser Ala Gly Glu Cys Gln Pro Arg Arg Asn Ile Val Phe 
65                  70                  75                  80  


Leu Lys Thr His Lys Thr Ala Ser Ser Thr Leu Leu Asn Ile Leu Phe 
                85                  90                  95      


Arg Phe Gly Gln Lys His Arg Leu Lys Phe Ala Phe Pro Asn Gly Arg 
            100                 105                 110         


Asn Asp Phe Asp Tyr Pro Thr Phe Phe Ala Arg Ser Leu Val Gln Asp 
        115                 120                 125             


Tyr Arg Pro Gly Ala Cys Phe Asn Ile Ile Cys Asn His Met Arg Phe 
    130                 135                 140                 


His Tyr Asp Glu Val Arg Gly Leu Val Pro Thr Asn Ala Ile Phe Ile 
145                 150                 155                 160 


Thr Val Leu Arg Asp Pro Ala Arg Leu Phe Glu Ser Ser Phe His Tyr 
                165                 170                 175     


Phe Gly Pro Val Val Pro Leu Thr Trp Lys Leu Ser Ala Gly Asp Lys 
            180                 185                 190         


Leu Thr Glu Phe Leu Gln Asp Pro Asp Arg Tyr Tyr Asp Pro Asn Gly 
        195                 200                 205             


Phe Asn Ala His Tyr Leu Arg Asn Leu Leu Phe Phe Asp Leu Gly Tyr 
    210                 215                 220                 


Asp Asn Ser Leu Asp Pro Ser Ser Pro Gln Val Gln Glu His Ile Leu 
225                 230                 235                 240 


Glu Val Glu Arg Arg Phe His Leu Val Leu Leu Gln Glu Tyr Phe Asp 
                245                 250                 255     


Glu Ser Leu Val Leu Leu Lys Asp Leu Leu Cys Trp Glu Leu Glu Asp 
            260                 265                 270         


Val Leu Tyr Phe Lys Leu Asn Ala Arg Arg Asp Ser Pro Val Pro Arg 
        275                 280                 285             


Leu Ser Gly Glu Leu Tyr Gly Arg Ala Thr Ala Trp Asn Met Leu Asp 
    290                 295                 300                 


Ser His Leu Tyr Arg His Phe Asn Ala Ser Phe Trp Arg Lys Val Glu 
305                 310                 315                 320 


Ala Phe Gly Arg Glu Arg Met Ala Arg Glu Val Ala Ala Leu Arg His 
                325                 330                 335     


Ala Asn Glu Arg Met Arg Thr Ile Cys Ile Asp Gly Gly His Ala Val 
            340                 345                 350         


Asp Ala Ala Ala Ile Gln Asp Glu Ala Met Gln Pro Trp Gln Pro Leu 
        355                 360                 365             


Gly Thr Lys Ser Ile Leu Gly Tyr Asn Leu Lys Lys Ser Ile Gly Gln 
    370                 375                 380                 


Arg His Ala Gln Leu Cys Arg Arg Met Leu Thr Pro Glu Ile Gln Tyr 
385                 390                 395                 400 


Leu Met Asp Leu Gly Ala Asn Leu Trp Val Thr Lys Leu Trp Lys Phe 
                405                 410                 415     


Ile Arg Asp Phe Leu Arg Trp 
            420             


<210>  5733
<211>  398
<212>  PRT
<213>  Homo Sapiens

<400>  5733

Met Met Ser Met Leu Gly Gly Leu Gln Arg Tyr Phe Arg Val Ile Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ala Leu Thr Leu Leu Leu Leu Ala Gly Phe Leu His 
            20                  25                  30          


Ser Asp Leu Glu Leu Asp Thr Pro Leu Phe Gly Gly Gln Ala Glu Gly 
        35                  40                  45              


Pro Pro Val Thr Asn Ile Met Phe Leu Lys Thr His Lys Thr Ala Ser 
    50                  55                  60                  


Ser Thr Val Leu Asn Ile Leu Tyr Arg Phe Ala Glu Thr His Asn Leu 
65                  70                  75                  80  


Ser Val Ala Leu Pro Ala Gly Ser Arg Val His Leu Gly Tyr Pro Trp 
                85                  90                  95      


Leu Phe Leu Ala Arg Tyr Val Glu Gly Val Gly Ser Gln Gln Arg Phe 
            100                 105                 110         


Asn Ile Met Cys Asn His Leu Arg Phe Asn Leu Pro Gln Val Gln Lys 
        115                 120                 125             


Val Met Pro Asn Asp Thr Phe Tyr Phe Ser Ile Leu Arg Asn Pro Val 
    130                 135                 140                 


Phe Gln Leu Glu Ser Ser Phe Ile Tyr Tyr Lys Thr Tyr Ala Pro Ala 
145                 150                 155                 160 


Phe Arg Gly Ala Pro Ser Leu Asp Ala Phe Leu Ala Ser Pro Arg Thr 
                165                 170                 175     


Phe Tyr Asn Asp Ser Arg His Leu Arg Asn Val Tyr Ala Lys Asn Asn 
            180                 185                 190         


Met Trp Phe Asp Phe Gly Phe Asp Pro Asn Ala Gln Cys Glu Glu Gly 
        195                 200                 205             


Tyr Val Arg Ala Arg Ile Ala Glu Val Glu Arg Arg Phe Arg Leu Val 
    210                 215                 220                 


Leu Ile Ala Glu His Leu Asp Glu Ser Leu Val Leu Leu Arg Arg Arg 
225                 230                 235                 240 


Leu Arg Trp Ala Leu Asp Asp Val Val Ala Phe Arg Leu Asn Ser Arg 
                245                 250                 255     


Ser Ala Arg Ser Val Ala Arg Leu Ser Pro Glu Thr Arg Glu Arg Ala 
            260                 265                 270         


Arg Ser Trp Cys Ala Leu Asp Trp Arg Leu Tyr Glu His Phe Asn Arg 
        275                 280                 285             


Thr Leu Trp Ala Gln Leu Arg Ala Glu Leu Gly Pro Arg Arg Leu Arg 
    290                 295                 300                 


Gly Glu Val Glu Arg Leu Arg Ala Arg Arg Arg Glu Leu Ala Ser Leu 
305                 310                 315                 320 


Cys Leu Gln Asp Gly Gly Ala Leu Lys Asn His Thr Gln Ile Arg Asp 
                325                 330                 335     


Pro Arg Leu Arg Pro Tyr Gln Ser Gly Lys Ala Asp Ile Leu Gly Tyr 
            340                 345                 350         


Asn Leu Arg Pro Gly Leu Asp Asn Gln Thr Leu Gly Val Cys Gln Arg 
        355                 360                 365             


Leu Val Met Pro Glu Leu Gln Tyr Met Ala Arg Leu Tyr Ala Leu Gln 
    370                 375                 380                 


Phe Pro Glu Lys Pro Leu Lys Asn Ile Pro Phe Leu Gly Ala 
385                 390                 395             


<210>  5734
<211>  431
<212>  PRT
<213>  Homo Sapiens

<400>  5734

Met Pro Pro Ile Leu Gln Arg Leu Gln Gln Ala Thr Lys Met Met Ser 
1               5                   10                  15      


Arg Arg Lys Ile Leu Leu Leu Val Leu Gly Cys Ser Thr Val Ser Leu 
            20                  25                  30          


Leu Ile His Gln Gly Ala Gln Leu Ser Trp Tyr Pro Lys Leu Phe Pro 
        35                  40                  45              


Leu Ser Cys Pro Pro Leu Arg Asn Ser Pro Pro Arg Pro Lys His Met 
    50                  55                  60                  


Thr Val Ala Phe Leu Lys Thr His Lys Thr Ala Gly Thr Thr Val Gln 
65                  70                  75                  80  


Asn Ile Leu Phe Arg Phe Ala Glu Arg His Asn Leu Thr Val Ala Leu 
                85                  90                  95      


Pro His Pro Ser Cys Glu His Gln Phe Cys Tyr Pro Arg Asn Phe Ser 
            100                 105                 110         


Ala His Phe Val His Pro Ala Thr Arg Pro Pro His Val Leu Ala Ser 
        115                 120                 125             


His Leu Arg Phe Asp Arg Ala Glu Leu Glu Arg Leu Met Pro Pro Ser 
    130                 135                 140                 


Thr Val Tyr Val Thr Ile Leu Arg Glu Pro Ala Ala Met Phe Glu Ser 
145                 150                 155                 160 


Leu Phe Ser Tyr Tyr Asn Gln Tyr Cys Pro Ala Phe Arg Arg Val Pro 
                165                 170                 175     


Asn Ala Ser Leu Glu Ala Phe Leu Arg Ala Pro Glu Ala Tyr Tyr Arg 
            180                 185                 190         


Ala Gly Glu His Phe Ala Met Phe Ala His Asn Thr Leu Ala Tyr Asp 
        195                 200                 205             


Leu Gly Gly Asp Asn Glu Arg Ser Pro Arg Asp Asp Ala Ala Tyr Leu 
    210                 215                 220                 


Ala Gly Leu Ile Arg Gln Val Glu Glu Val Phe Ser Leu Val Met Ile 
225                 230                 235                 240 


Ala Glu Tyr Phe Asp Glu Ser Leu Val Leu Leu Arg Arg Leu Leu Ala 
                245                 250                 255     


Trp Asp Leu Asp Asp Val Leu Tyr Ala Lys Leu Asn Ala Arg Ala Ala 
            260                 265                 270         


Ser Ser Arg Leu Ala Ala Ile Pro Ala Ala Leu Ala Arg Ala Ala Arg 
        275                 280                 285             


Thr Trp Asn Ala Leu Asp Ala Gly Leu Tyr Asp His Phe Asn Ala Thr 
    290                 295                 300                 


Phe Trp Arg His Val Ala Arg Ala Gly Arg Ala Cys Val Glu Arg Glu 
305                 310                 315                 320 


Ala Arg Glu Leu Arg Glu Ala Arg Gln Arg Leu Leu Arg Arg Cys Phe 
                325                 330                 335     


Gly Asp Glu Pro Leu Leu Arg Pro Ala Ala Gln Ile Arg Thr Lys Gln 
            340                 345                 350         


Leu Gln Pro Trp Gln Pro Ser Arg Lys Val Asp Ile Met Gly Tyr Asp 
        355                 360                 365             


Leu Pro Gly Gly Gly Ala Gly Pro Ala Thr Glu Ala Cys Leu Lys Leu 
    370                 375                 380                 


Ala Met Pro Glu Val Gln Tyr Ser Asn Tyr Leu Leu Arg Lys Gln Lys 
385                 390                 395                 400 


Arg Arg Gly Gly Ala Arg Ala Arg Pro Glu Pro Val Leu Asp Asn Pro 
                405                 410                 415     


Pro Pro Arg Pro Ile Arg Val Leu Pro Arg Gly Pro Gln Gly Pro 
            420                 425                 430     


<210>  5735
<211>  431
<212>  PRT
<213>  Homo Sapiens

<400>  5735

Met Pro Pro Ile Leu Gln Arg Leu Gln Gln Ala Thr Lys Met Met Ser 
1               5                   10                  15      


Arg Arg Lys Ile Leu Leu Leu Val Leu Gly Cys Ser Thr Val Ser Leu 
            20                  25                  30          


Leu Ile His Gln Gly Ala Gln Leu Ser Trp Tyr Pro Lys Leu Phe Pro 
        35                  40                  45              


Leu Ser Cys Pro Pro Leu Arg Asn Ser Pro Pro Arg Pro Lys His Met 
    50                  55                  60                  


Thr Val Ala Phe Leu Lys Thr His Lys Thr Ala Gly Thr Thr Val Gln 
65                  70                  75                  80  


Asn Ile Leu Phe Arg Phe Ala Glu Arg His Asn Leu Thr Val Ala Leu 
                85                  90                  95      


Pro His Pro Ser Cys Glu His Gln Phe Cys Tyr Pro Arg Asn Phe Ser 
            100                 105                 110         


Ala His Phe Val His Pro Ala Thr Arg Pro Pro His Val Leu Ala Ser 
        115                 120                 125             


His Leu Arg Phe Asp Arg Ala Glu Leu Glu Arg Leu Met Pro Pro Ser 
    130                 135                 140                 


Thr Val Tyr Val Thr Ile Leu Arg Glu Pro Ala Ala Met Phe Glu Ser 
145                 150                 155                 160 


Leu Phe Ser Tyr Tyr Asn Gln Tyr Cys Pro Ala Phe Arg Arg Val Pro 
                165                 170                 175     


Asn Ala Ser Leu Glu Ala Phe Leu Arg Ala Pro Glu Ala Tyr Tyr Arg 
            180                 185                 190         


Ala Gly Glu His Phe Ala Met Phe Ala His Asn Thr Leu Ala Tyr Asp 
        195                 200                 205             


Leu Gly Gly Asp Asn Glu Arg Ser Pro Arg Asp Asp Ala Ala Tyr Leu 
    210                 215                 220                 


Ala Gly Leu Ile Arg Gln Val Glu Glu Val Phe Ser Leu Val Met Ile 
225                 230                 235                 240 


Ala Glu Tyr Phe Asp Glu Ser Leu Val Leu Leu Arg Arg Leu Leu Ala 
                245                 250                 255     


Trp Asp Leu Asp Asp Val Leu Tyr Ala Lys Leu Asn Ala Arg Ala Ala 
            260                 265                 270         


Ser Ser Arg Leu Ala Ala Ile Pro Ala Ala Leu Ala Arg Ala Ala Arg 
        275                 280                 285             


Thr Trp Asn Ala Leu Asp Ala Gly Leu Tyr Asp His Phe Asn Ala Thr 
    290                 295                 300                 


Phe Trp Arg His Val Ala Arg Ala Gly Arg Ala Cys Val Glu Arg Glu 
305                 310                 315                 320 


Ala Arg Glu Leu Arg Glu Ala Arg Gln Arg Leu Leu Arg Arg Cys Phe 
                325                 330                 335     


Gly Asp Glu Pro Leu Leu Arg Pro Ala Ala Gln Ile Arg Thr Lys Gln 
            340                 345                 350         


Leu Gln Pro Trp Gln Pro Ser Arg Lys Val Asp Ile Met Gly Tyr Asp 
        355                 360                 365             


Leu Pro Gly Gly Gly Ala Gly Pro Ala Thr Glu Ala Cys Leu Lys Leu 
    370                 375                 380                 


Ala Met Pro Glu Val Gln Tyr Ser Asn Tyr Leu Leu Arg Lys Gln Lys 
385                 390                 395                 400 


Arg Arg Gly Gly Ala Arg Ala Arg Pro Glu Pro Val Leu Asp Asn Pro 
                405                 410                 415     


Pro Pro Arg Pro Ile Arg Val Leu Pro Arg Gly Pro Gln Gly Pro 
            420                 425                 430     


<210>  5736
<211>  62
<212>  PRT
<213>  Homo Sapiens

<400>  5736

Lys Ala Met Thr Ala Ala Ala Gly Ser Ala Gly Arg Ala Ala Val Pro 
1               5                   10                  15      


Leu Leu Leu Cys Ala Leu Leu Ala Pro Gly Gly Ala Tyr Val Leu Asp 
            20                  25                  30          


Asp Ser Asp Gly Leu Gly Arg Glu Phe Asp Gly Ile Gly Ala Val Ser 
        35                  40                  45              


Gly Gly Gly Asp Trp Cys Leu Lys Val Ser Leu Lys Gly Arg 
    50                  55                  60          


<210>  5737
<211>  685
<212>  PRT
<213>  Homo Sapiens

<400>  5737

Met Ala Glu Trp Leu Leu Ser Ala Ser Trp Gln Arg Arg Ala Lys Ala 
1               5                   10                  15      


Met Thr Ala Ala Ala Gly Ser Ala Gly Arg Ala Ala Val Pro Leu Leu 
            20                  25                  30          


Leu Cys Ala Leu Leu Ala Pro Gly Gly Ala Tyr Val Leu Asp Asp Ser 
        35                  40                  45              


Asp Gly Leu Gly Arg Glu Phe Asp Gly Ile Gly Ala Val Ser Gly Gly 
    50                  55                  60                  


Gly Ala Thr Ser Arg Leu Leu Val Asn Tyr Pro Glu Pro Tyr Arg Ser 
65                  70                  75                  80  


Gln Ile Leu Asp Tyr Leu Phe Lys Pro Asn Phe Gly Ala Ser Leu His 
                85                  90                  95      


Ile Leu Lys Val Glu Ile Gly Gly Asp Gly Gln Thr Thr Asp Gly Thr 
            100                 105                 110         


Glu Pro Ser His Met His Tyr Ala Leu Asp Glu Asn Tyr Phe Arg Gly 
        115                 120                 125             


Tyr Glu Trp Trp Leu Met Lys Glu Ala Lys Lys Arg Asn Pro Asn Ile 
    130                 135                 140                 


Thr Leu Ile Gly Leu Pro Trp Ser Phe Pro Gly Trp Leu Gly Lys Gly 
145                 150                 155                 160 


Phe Asp Trp Pro Tyr Val Asn Leu Gln Leu Thr Ala Tyr Tyr Val Val 
                165                 170                 175     


Thr Trp Ile Val Gly Ala Lys Arg Tyr His Asp Leu Asp Ile Asp Tyr 
            180                 185                 190         


Ile Gly Ile Trp Asn Glu Arg Ser Tyr Asn Ala Asn Tyr Ile Lys Ile 
        195                 200                 205             


Leu Arg Lys Met Leu Asn Tyr Gln Gly Leu Gln Arg Val Lys Ile Ile 
    210                 215                 220                 


Ala Ser Asp Asn Leu Trp Glu Ser Ile Ser Ala Ser Met Leu Leu Asp 
225                 230                 235                 240 


Ala Glu Leu Phe Lys Val Val Asp Val Ile Gly Ala His Tyr Pro Gly 
                245                 250                 255     


Thr His Ser Ala Lys Asp Ala Lys Leu Thr Gly Lys Lys Leu Trp Ser 
            260                 265                 270         


Ser Glu Asp Phe Ser Thr Leu Asn Ser Asp Met Gly Ala Gly Cys Trp 
        275                 280                 285             


Gly Arg Ile Leu Asn Gln Asn Tyr Ile Asn Gly Tyr Met Thr Ser Thr 
    290                 295                 300                 


Ile Ala Trp Asn Leu Val Ala Ser Tyr Tyr Glu Gln Leu Pro Tyr Gly 
305                 310                 315                 320 


Arg Cys Gly Leu Met Thr Ala Gln Glu Pro Trp Ser Gly His Tyr Val 
                325                 330                 335     


Val Glu Ser Pro Val Trp Val Ser Ala His Thr Thr Gln Phe Thr Gln 
            340                 345                 350         


Pro Gly Trp Tyr Tyr Leu Lys Thr Val Gly His Leu Glu Lys Gly Gly 
        355                 360                 365             


Ser Tyr Val Ala Leu Thr Asp Gly Leu Gly Asn Leu Thr Ile Ile Ile 
    370                 375                 380                 


Glu Thr Met Ser His Lys His Ser Lys Cys Ile Arg Pro Phe Leu Pro 
385                 390                 395                 400 


Tyr Phe Asn Val Ser Gln Gln Phe Ala Thr Phe Val Leu Lys Gly Ser 
                405                 410                 415     


Phe Ser Glu Ile Pro Glu Leu Gln Val Trp Tyr Thr Lys Leu Gly Lys 
            420                 425                 430         


Thr Ser Glu Arg Phe Leu Phe Lys Gln Leu Asp Ser Leu Trp Leu Leu 
        435                 440                 445             


Asp Ser Asp Gly Ser Phe Thr Leu Ser Leu His Glu Asp Glu Leu Phe 
    450                 455                 460                 


Thr Leu Thr Thr Leu Thr Thr Gly Arg Lys Gly Ser Tyr Pro Leu Pro 
465                 470                 475                 480 


Pro Lys Ser Gln Pro Phe Pro Ser Thr Tyr Lys Asp Asp Phe Asn Val 
                485                 490                 495     


Asp Tyr Pro Phe Phe Ser Glu Ala Pro Asn Phe Ala Asp Gln Thr Gly 
            500                 505                 510         


Val Phe Glu Tyr Phe Thr Asn Ile Glu Asp Pro Gly Glu His His Phe 
        515                 520                 525             


Thr Leu Arg Gln Val Leu Asn Gln Arg Pro Ile Thr Trp Ala Ala Asp 
    530                 535                 540                 


Ala Ser Asn Thr Ile Ser Ile Ile Gly Asp Tyr Asn Trp Thr Asn Leu 
545                 550                 555                 560 


Thr Ile Lys Cys Asp Val Tyr Ile Glu Thr Pro Asp Thr Gly Gly Val 
                565                 570                 575     


Phe Ile Ala Gly Arg Val Asn Lys Gly Gly Ile Leu Ile Arg Ser Ala 
            580                 585                 590         


Arg Gly Ile Phe Phe Trp Ile Phe Ala Asn Gly Ser Tyr Arg Val Thr 
        595                 600                 605             


Gly Asp Leu Ala Gly Trp Ile Ile Tyr Ala Leu Gly Arg Val Glu Val 
    610                 615                 620                 


Thr Ala Lys Lys Trp Tyr Thr Leu Thr Leu Thr Ile Lys Gly His Phe 
625                 630                 635                 640 


Thr Ser Gly Met Leu Asn Asp Lys Ser Leu Trp Thr Asp Ile Pro Val 
                645                 650                 655     


Asn Phe Pro Lys Asn Gly Trp Ala Ala Ile Gly Thr His Ser Phe Glu 
            660                 665                 670         


Phe Ala Gln Phe Asp Asn Phe Leu Val Glu Ala Thr Arg 
        675                 680                 685 


<210>  5738
<211>  211
<212>  PRT
<213>  Homo Sapiens

<400>  5738

Met Ala Glu Trp Leu Leu Ser Ala Ser Trp Gln Arg Arg Ala Lys Ala 
1               5                   10                  15      


Met Thr Ala Ala Ala Gly Ser Ala Gly Arg Ala Ala Val Pro Leu Leu 
            20                  25                  30          


Leu Cys Ala Leu Leu Ala Pro Gly Gly Ala Tyr Val Leu Asp Asp Ser 
        35                  40                  45              


Asp Gly Leu Gly Arg Glu Phe Asp Gly Ile Gly Ala Val Ser Gly Gly 
    50                  55                  60                  


Gly Ala Thr Ser Arg Leu Leu Val Asn Tyr Pro Glu Pro Tyr Arg Ser 
65                  70                  75                  80  


Gln Ile Leu Asp Tyr Leu Phe Lys Pro Asn Phe Gly Ala Ser Leu His 
                85                  90                  95      


Ile Leu Lys Val Glu Ile Gly Gly Asp Gly Gln Thr Thr Asp Gly Thr 
            100                 105                 110         


Glu Pro Ser His Met His Tyr Ala Leu Asp Glu Asn Tyr Phe Arg Gly 
        115                 120                 125             


Tyr Glu Trp Trp Leu Met Lys Glu Ala Lys Lys Arg Asn Pro Asn Ile 
    130                 135                 140                 


Thr Leu Ile Gly Leu Pro Trp Ser Phe Pro Gly Trp Leu Gly Lys Gly 
145                 150                 155                 160 


Phe Asp Trp Pro Tyr Val Asn Leu Gln Leu Thr Ala Tyr Tyr Val Val 
                165                 170                 175     


Thr Trp Ile Val Gly Ala Lys Arg Tyr His Asp Leu Asp Ile Asp Tyr 
            180                 185                 190         


Ile Gly Ile Trp Asn Glu Arg Ser Tyr Asn Ala Asn Tyr Ile Lys Val 
        195                 200                 205             


Phe Gly Glu 
    210     


<210>  5739
<211>  112
<212>  PRT
<213>  Homo Sapiens

<400>  5739

Met Ala Glu Trp Leu Leu Ser Ala Ser Trp Gln Arg Arg Ala Lys Ala 
1               5                   10                  15      


Met Thr Ala Ala Ala Gly Ser Ala Gly Arg Ala Ala Val Pro Leu Leu 
            20                  25                  30          


Leu Cys Ala Leu Leu Ala Pro Gly Gly Ala Tyr Val Leu Asp Asp Ser 
        35                  40                  45              


Asp Gly Leu Gly Arg Glu Phe Asp Gly Ile Gly Ala Val Ser Gly Gly 
    50                  55                  60                  


Gly Ala Thr Ser Arg Leu Leu Val Asn Tyr Pro Glu Pro Tyr Arg Ser 
65                  70                  75                  80  


Gln Ile Leu Asp Tyr Leu Phe Lys Pro Asn Phe Gly Ala Ser Leu His 
                85                  90                  95      


Ile Leu Lys Val Glu Ile Gly Gly Asp Gly Gln Thr Thr Asp Ile Leu 
            100                 105                 110         


<210>  5740
<211>  662
<212>  PRT
<213>  Homo Sapiens

<400>  5740

Met Ala Glu Trp Leu Leu Ser Ala Ser Trp Gln Arg Arg Ala Lys Ala 
1               5                   10                  15      


Met Thr Ala Ala Ala Gly Ser Ala Gly Arg Ala Ala Val Pro Leu Leu 
            20                  25                  30          


Leu Cys Ala Leu Leu Ala Pro Gly Gly Ala Tyr Val Leu Asp Asp Ser 
        35                  40                  45              


Asp Gly Leu Gly Arg Glu Phe Asp Gly Ile Gly Ala Val Ser Gly Gly 
    50                  55                  60                  


Gly Pro Asn Phe Gly Ala Ser Leu His Ile Leu Lys Val Glu Ile Gly 
65                  70                  75                  80  


Gly Asp Gly Gln Thr Thr Asp Gly Thr Glu Pro Ser His Met His Tyr 
                85                  90                  95      


Ala Leu Asp Glu Asn Tyr Phe Arg Gly Tyr Glu Trp Trp Leu Met Lys 
            100                 105                 110         


Glu Ala Lys Lys Arg Asn Pro Asn Ile Thr Leu Ile Gly Leu Pro Trp 
        115                 120                 125             


Ser Phe Pro Gly Trp Leu Gly Lys Gly Phe Asp Trp Pro Tyr Val Asn 
    130                 135                 140                 


Leu Gln Leu Thr Ala Tyr Tyr Val Val Thr Trp Ile Val Gly Ala Lys 
145                 150                 155                 160 


Arg Tyr His Asp Leu Asp Ile Asp Tyr Ile Gly Ile Trp Asn Glu Arg 
                165                 170                 175     


Ser Tyr Asn Ala Asn Tyr Ile Lys Ile Leu Arg Lys Met Leu Asn Tyr 
            180                 185                 190         


Gln Gly Leu Gln Arg Val Lys Ile Ile Ala Ser Asp Asn Leu Trp Glu 
        195                 200                 205             


Ser Ile Ser Ala Ser Met Leu Leu Asp Ala Glu Leu Phe Lys Val Val 
    210                 215                 220                 


Asp Val Ile Gly Ala His Tyr Pro Gly Thr His Ser Ala Lys Asp Ala 
225                 230                 235                 240 


Lys Leu Thr Gly Lys Lys Leu Trp Ser Ser Glu Asp Phe Ser Thr Leu 
                245                 250                 255     


Asn Ser Asp Met Gly Ala Gly Cys Trp Gly Arg Ile Leu Asn Gln Asn 
            260                 265                 270         


Tyr Ile Asn Gly Tyr Met Thr Ser Thr Ile Ala Trp Asn Leu Val Ala 
        275                 280                 285             


Ser Tyr Tyr Glu Gln Leu Pro Tyr Gly Arg Cys Gly Leu Met Thr Ala 
    290                 295                 300                 


Gln Glu Pro Trp Ser Gly His Tyr Val Val Glu Ser Pro Val Trp Val 
305                 310                 315                 320 


Ser Ala His Thr Thr Gln Phe Thr Gln Pro Gly Trp Tyr Tyr Leu Lys 
                325                 330                 335     


Thr Val Gly His Leu Glu Lys Gly Gly Ser Tyr Val Ala Leu Thr Asp 
            340                 345                 350         


Gly Leu Gly Asn Leu Thr Ile Ile Ile Glu Thr Met Ser His Lys His 
        355                 360                 365             


Ser Lys Cys Ile Arg Pro Phe Leu Pro Tyr Phe Asn Val Ser Gln Gln 
    370                 375                 380                 


Phe Ala Thr Phe Val Leu Lys Gly Ser Phe Ser Glu Ile Pro Glu Leu 
385                 390                 395                 400 


Gln Val Trp Tyr Thr Lys Leu Gly Lys Thr Ser Glu Arg Phe Leu Phe 
                405                 410                 415     


Lys Gln Leu Asp Ser Leu Trp Leu Leu Asp Ser Asp Gly Ser Phe Thr 
            420                 425                 430         


Leu Ser Leu His Glu Asp Glu Leu Phe Thr Leu Thr Thr Leu Thr Thr 
        435                 440                 445             


Gly Arg Lys Gly Ser Tyr Pro Leu Pro Pro Lys Ser Gln Pro Phe Pro 
    450                 455                 460                 


Ser Thr Tyr Lys Asp Asp Phe Asn Val Asp Tyr Pro Phe Phe Ser Glu 
465                 470                 475                 480 


Ala Pro Asn Phe Ala Asp Gln Thr Gly Val Phe Glu Tyr Phe Thr Asn 
                485                 490                 495     


Ile Glu Asp Pro Gly Glu His His Phe Thr Leu Arg Gln Val Leu Asn 
            500                 505                 510         


Gln Arg Pro Ile Thr Trp Ala Ala Asp Ala Ser Asn Thr Ile Ser Ile 
        515                 520                 525             


Ile Gly Asp Tyr Asn Trp Thr Asn Leu Thr Ile Lys Cys Asp Val Tyr 
    530                 535                 540                 


Ile Glu Thr Pro Asp Thr Gly Gly Val Phe Ile Ala Gly Arg Val Asn 
545                 550                 555                 560 


Lys Gly Gly Ile Leu Ile Arg Ser Ala Arg Gly Ile Phe Phe Trp Ile 
                565                 570                 575     


Phe Ala Asn Gly Ser Tyr Arg Val Thr Gly Asp Leu Ala Gly Trp Ile 
            580                 585                 590         


Ile Tyr Ala Leu Gly Arg Val Glu Val Thr Ala Lys Lys Trp Tyr Thr 
        595                 600                 605             


Leu Thr Leu Thr Ile Lys Gly His Phe Thr Ser Gly Met Leu Asn Asp 
    610                 615                 620                 


Lys Ser Leu Trp Thr Asp Ile Pro Val Asn Phe Pro Lys Asn Gly Trp 
625                 630                 635                 640 


Ala Ala Ile Gly Thr His Ser Phe Glu Phe Ala Gln Phe Asp Asn Phe 
                645                 650                 655     


Leu Val Glu Ala Thr Arg 
            660         


<210>  5741
<211>  589
<212>  PRT
<213>  Homo Sapiens

<400>  5741

Met Gly Phe Met Val Ala Asp Leu Trp Ala Thr Ser Arg Leu Leu Val 
1               5                   10                  15      


Asn Tyr Pro Glu Pro Tyr Arg Ser Gln Ile Leu Asp Tyr Leu Phe Lys 
            20                  25                  30          


Pro Asn Phe Gly Ala Ser Leu His Ile Leu Lys Val Glu Ile Gly Gly 
        35                  40                  45              


Asp Gly Gln Thr Thr Asp Gly Thr Glu Pro Ser His Met His Tyr Ala 
    50                  55                  60                  


Leu Asp Glu Asn Tyr Phe Arg Gly Tyr Glu Trp Trp Leu Met Lys Glu 
65                  70                  75                  80  


Ala Lys Lys Arg Asn Pro Asn Ile Thr Leu Ile Gly Leu Pro Trp Ser 
                85                  90                  95      


Phe Pro Gly Trp Leu Gly Lys Gly Phe Asp Trp Pro Tyr Val Asn Leu 
            100                 105                 110         


Gln Leu Thr Ala Tyr Tyr Val Val Thr Trp Ile Val Gly Ala Lys Arg 
        115                 120                 125             


Tyr His Asp Leu Asp Ile Asp Tyr Ile Gly Ile Trp Asn Glu Arg Ser 
    130                 135                 140                 


Tyr Asn Ala Asn Tyr Ile Lys Ile Leu Arg Lys Met Leu Asn Tyr Gln 
145                 150                 155                 160 


Gly Leu Gln Arg Val Lys Ile Ile Ala Ser Asp Asn Leu Trp Glu Ser 
                165                 170                 175     


Ile Ser Ala Ser Met Leu Leu Asp Ala Glu Leu Phe Lys Val Val Asp 
            180                 185                 190         


Val Ile Gly Ala His Tyr Pro Gly Thr His Ser Ala Lys Asp Ala Lys 
        195                 200                 205             


Leu Thr Gly Lys Lys Leu Trp Ser Ser Glu Asp Phe Ser Thr Leu Asn 
    210                 215                 220                 


Ser Asp Met Gly Ala Gly Cys Trp Gly Arg Ile Leu Asn Gln Asn Tyr 
225                 230                 235                 240 


Ile Asn Gly Tyr Met Thr Ser Thr Ile Ala Trp Asn Leu Val Ala Ser 
                245                 250                 255     


Tyr Tyr Glu Gln Leu Pro Tyr Gly Arg Cys Gly Leu Met Thr Ala Gln 
            260                 265                 270         


Glu Pro Trp Ser Gly His Tyr Val Val Glu Ser Pro Val Trp Val Ser 
        275                 280                 285             


Ala His Thr Thr Gln Phe Thr Gln Pro Gly Trp Tyr Tyr Leu Lys Thr 
    290                 295                 300                 


Val Gly His Leu Glu Lys Gly Gly Ser Tyr Val Ala Leu Thr Asp Gly 
305                 310                 315                 320 


Leu Gly Asn Leu Thr Ile Ile Ile Glu Thr Met Ser His Lys His Ser 
                325                 330                 335     


Lys Cys Ile Arg Pro Phe Leu Pro Tyr Phe Asn Val Ser Gln Gln Phe 
            340                 345                 350         


Ala Thr Phe Val Leu Lys Gly Ser Phe Ser Glu Ile Pro Glu Leu Gln 
        355                 360                 365             


Val Trp Tyr Thr Lys Leu Gly Lys Thr Ser Glu Arg Phe Leu Phe Lys 
    370                 375                 380                 


Gln Leu Asp Ser Leu Trp Leu Leu Asp Ser Asp Gly Ser Phe Thr Leu 
385                 390                 395                 400 


Ser Leu His Glu Asp Glu Leu Phe Thr Leu Thr Thr Leu Thr Thr Gly 
                405                 410                 415     


Arg Lys Gly Ser Tyr Pro Leu Pro Pro Lys Ser Gln Pro Phe Pro Ser 
            420                 425                 430         


Thr Tyr Lys Asp Asp Phe Asn Val Asp Tyr Pro Phe Phe Ser Glu Ala 
        435                 440                 445             


Pro Asn Phe Ala Asp Gln Thr Gly Val Phe Glu Tyr Phe Thr Asn Ile 
    450                 455                 460                 


Glu Asp Pro Gly Glu His His Phe Thr Leu Arg Gln Val Leu Asn Gln 
465                 470                 475                 480 


Arg Pro Ile Thr Trp Ala Ala Asp Ala Ser Asn Thr Ile Ser Ile Ile 
                485                 490                 495     


Gly Asp Tyr Asn Trp Thr Asn Leu Thr Ile Lys Cys Asp Val Tyr Ile 
            500                 505                 510         


Glu Thr Pro Asp Thr Gly Gly Val Phe Ile Ala Gly Arg Val Asn Lys 
        515                 520                 525             


Gly Gly Ile Leu Ile Arg Ser Ala Arg Gly Ile Phe Phe Trp Ile Phe 
    530                 535                 540                 


Ala Asn Gly Ser Tyr Arg Val Thr Gly Asp Leu Ala Gly Trp Ile Ile 
545                 550                 555                 560 


Tyr Ala Leu Gly Arg Val Glu Val Thr Ala Lys Lys Trp Tyr Thr Leu 
                565                 570                 575     


Thr Leu Thr Ile Lys Val Ala Gly Arg Arg Lys Lys Thr 
            580                 585                 


<210>  5742
<211>  659
<212>  PRT
<213>  Homo Sapiens

<400>  5742

Met Leu Gly Lys Ser His Gly Arg Ala Thr His Gly Pro Leu Pro Leu 
1               5                   10                  15      


Ala Asp Leu Gly Ile His Leu Pro Cys Val Lys Val Leu His Gln Val 
            20                  25                  30          


Thr Pro Glu Glu Lys Pro Ala Ala Thr Ser Arg Leu Leu Val Asn Tyr 
        35                  40                  45              


Pro Glu Pro Tyr Arg Ser Gln Ile Leu Asp Tyr Leu Phe Lys Pro Asn 
    50                  55                  60                  


Phe Gly Ala Ser Leu His Ile Leu Lys Val Glu Ile Gly Gly Asp Gly 
65                  70                  75                  80  


Gln Thr Thr Asp Gly Thr Glu Pro Ser His Met His Tyr Ala Leu Asp 
                85                  90                  95      


Glu Asn Tyr Phe Arg Gly Tyr Glu Trp Trp Leu Met Lys Glu Ala Lys 
            100                 105                 110         


Lys Arg Asn Pro Asn Ile Thr Leu Ile Gly Leu Pro Trp Ser Phe Pro 
        115                 120                 125             


Gly Trp Leu Gly Lys Gly Phe Asp Trp Pro Tyr Val Asn Leu Gln Leu 
    130                 135                 140                 


Thr Ala Tyr Tyr Val Val Thr Trp Ile Val Gly Ala Lys Arg Tyr His 
145                 150                 155                 160 


Asp Leu Asp Ile Asp Tyr Ile Gly Ile Trp Asn Glu Arg Ser Tyr Asn 
                165                 170                 175     


Ala Asn Tyr Ile Lys Ile Leu Arg Lys Met Leu Asn Tyr Gln Gly Leu 
            180                 185                 190         


Gln Arg Val Lys Ile Ile Ala Ser Asp Asn Leu Trp Glu Ser Ile Ser 
        195                 200                 205             


Ala Ser Met Leu Leu Asp Ala Glu Leu Phe Lys Val Val Asp Val Ile 
    210                 215                 220                 


Gly Ala His Tyr Pro Gly Thr His Ser Ala Lys Asp Ala Lys Leu Thr 
225                 230                 235                 240 


Gly Lys Lys Leu Trp Ser Ser Glu Asp Phe Ser Thr Leu Asn Ser Asp 
                245                 250                 255     


Met Gly Ala Gly Cys Trp Gly Arg Ile Leu Asn Gln Asn Tyr Ile Asn 
            260                 265                 270         


Gly Tyr Met Thr Ser Thr Ile Ala Trp Asn Leu Val Ala Ser Tyr Tyr 
        275                 280                 285             


Glu Gln Leu Pro Tyr Gly Arg Cys Gly Leu Met Thr Ala Gln Glu Pro 
    290                 295                 300                 


Trp Ser Gly His Tyr Val Val Glu Ser Pro Val Trp Val Ser Ala His 
305                 310                 315                 320 


Thr Thr Gln Phe Thr Gln Pro Gly Trp Tyr Tyr Leu Lys Thr Val Gly 
                325                 330                 335     


His Leu Glu Lys Gly Gly Ser Tyr Val Ala Leu Thr Asp Gly Leu Gly 
            340                 345                 350         


Asn Leu Thr Ile Ile Ile Glu Thr Met Ser His Lys His Ser Lys Cys 
        355                 360                 365             


Ile Arg Pro Phe Leu Pro Tyr Phe Asn Val Ser Gln Gln Phe Ala Thr 
    370                 375                 380                 


Phe Val Leu Lys Gly Ser Phe Ser Glu Ile Pro Glu Leu Gln Val Trp 
385                 390                 395                 400 


Tyr Thr Lys Leu Gly Lys Thr Ser Glu Arg Phe Leu Phe Lys Gln Leu 
                405                 410                 415     


Asp Ser Leu Trp Leu Leu Asp Ser Asp Gly Ser Phe Thr Leu Ser Leu 
            420                 425                 430         


His Glu Asp Glu Leu Phe Thr Leu Thr Thr Leu Thr Thr Gly Arg Lys 
        435                 440                 445             


Gly Ser Tyr Pro Leu Pro Pro Lys Ser Gln Pro Phe Pro Ser Thr Tyr 
    450                 455                 460                 


Lys Asp Asp Phe Asn Val Asp Tyr Pro Phe Phe Ser Glu Ala Pro Asn 
465                 470                 475                 480 


Phe Ala Asp Gln Thr Gly Val Phe Glu Tyr Phe Thr Asn Ile Glu Asp 
                485                 490                 495     


Pro Gly Glu His His Phe Thr Leu Arg Gln Val Leu Asn Gln Arg Pro 
            500                 505                 510         


Ile Thr Trp Ala Ala Asp Ala Ser Asn Thr Ile Ser Ile Ile Gly Asp 
        515                 520                 525             


Tyr Asn Trp Thr Asn Leu Thr Ile Lys Cys Asp Val Tyr Ile Glu Thr 
    530                 535                 540                 


Pro Asp Thr Gly Gly Val Phe Ile Ala Gly Arg Val Asn Lys Gly Gly 
545                 550                 555                 560 


Ile Leu Ile Arg Ser Ala Arg Gly Ile Phe Phe Trp Ile Phe Ala Asn 
                565                 570                 575     


Gly Ser Tyr Arg Val Thr Gly Asp Leu Ala Gly Trp Ile Ile Tyr Ala 
            580                 585                 590         


Leu Gly Arg Val Glu Val Thr Ala Lys Lys Trp Tyr Thr Leu Thr Leu 
        595                 600                 605             


Thr Ile Lys Gly His Phe Thr Ser Gly Met Leu Asn Asp Lys Ser Leu 
    610                 615                 620                 


Trp Thr Asp Ile Pro Val Asn Phe Pro Lys Asn Gly Trp Ala Ala Ile 
625                 630                 635                 640 


Gly Thr His Ser Phe Glu Phe Ala Gln Phe Asp Asn Phe Leu Val Glu 
                645                 650                 655     


Ala Thr Arg 
            


<210>  5743
<211>  434
<212>  PRT
<213>  Homo Sapiens

<400>  5743

Met Leu Asn Tyr Gln Gly Leu Gln Arg Val Lys Ile Ile Ala Ser Asp 
1               5                   10                  15      


Asn Leu Trp Glu Ser Ile Ser Ala Ser Met Leu Leu Asp Ala Glu Leu 
            20                  25                  30          


Phe Lys Val Val Asp Val Ile Gly Ala His Tyr Pro Gly Thr His Ser 
        35                  40                  45              


Ala Lys Asp Ala Lys Leu Thr Gly Lys Lys Leu Trp Ser Ser Glu Asp 
    50                  55                  60                  


Phe Ser Thr Leu Asn Ser Asp Met Gly Ala Gly Cys Trp Gly Arg Ile 
65                  70                  75                  80  


Leu Asn Gln Asn Tyr Ile Asn Gly Tyr Met Thr Ser Thr Ile Ala Trp 
                85                  90                  95      


Asn Leu Val Ala Ser Tyr Tyr Glu Gln Leu Pro Tyr Gly Arg Cys Gly 
            100                 105                 110         


Leu Met Thr Ala Gln Glu Pro Trp Ser Gly His Tyr Val Val Glu Ser 
        115                 120                 125             


Pro Val Trp Val Ser Ala His Thr Thr Gln Phe Thr Gln Pro Gly Trp 
    130                 135                 140                 


Tyr Tyr Leu Lys Thr Val Gly His Leu Glu Lys Gly Gly Ser Tyr Val 
145                 150                 155                 160 


Ala Leu Thr Asp Gly Leu Gly Asn Leu Thr Ile Ile Ile Glu Thr Met 
                165                 170                 175     


Ser His Lys His Ser Lys Cys Ile Arg Pro Phe Leu Pro Tyr Phe Asn 
            180                 185                 190         


Val Ser Gln Gln Phe Ala Thr Phe Val Leu Lys Gly Ser Phe Ser Glu 
        195                 200                 205             


Ile Pro Glu Leu Gln Val Trp Tyr Thr Lys Leu Gly Lys Thr Ser Glu 
    210                 215                 220                 


Arg Phe Leu Phe Lys Gln Leu Asp Ser Leu Trp Leu Leu Asp Ser Asp 
225                 230                 235                 240 


Gly Ser Phe Thr Leu Ser Leu His Glu Asp Glu Leu Phe Thr Leu Thr 
                245                 250                 255     


Thr Leu Thr Thr Gly Arg Lys Gly Ser Tyr Pro Leu Pro Pro Lys Ser 
            260                 265                 270         


Gln Pro Phe Pro Ser Thr Tyr Lys Asp Asp Phe Asn Val Asp Tyr Pro 
        275                 280                 285             


Phe Phe Ser Glu Ala Pro Asn Phe Ala Asp Gln Thr Gly Val Phe Glu 
    290                 295                 300                 


Tyr Phe Thr Asn Ile Glu Asp Pro Gly Glu His His Phe Thr Leu Arg 
305                 310                 315                 320 


Gln Val Leu Asn Gln Arg Pro Ile Thr Trp Ala Ala Asp Ala Ser Asn 
                325                 330                 335     


Thr Ile Ser Ile Ile Gly Asp Tyr Asn Trp Thr Asn Leu Thr Ile Lys 
            340                 345                 350         


Cys Asp Val Tyr Ile Glu Thr Pro Asp Thr Gly Gly Val Phe Ile Ala 
        355                 360                 365             


Gly Arg Val Asn Lys Gly Gly Ile Leu Ile Arg Ser Ala Arg Gly Ile 
    370                 375                 380                 


Phe Phe Trp Ile Phe Ala Asn Gly Ser Tyr Arg Val Thr Gly Asp Leu 
385                 390                 395                 400 


Ala Gly Trp Ile Ile Tyr Ala Leu Gly Arg Val Glu Val Thr Ala Lys 
                405                 410                 415     


Lys Trp Tyr Thr Leu Thr Leu Thr Ile Lys Val Ala Gly Arg Arg Lys 
            420                 425                 430         


Lys Thr 
        


<210>  5744
<211>  72
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5744

Xaa Lys Leu Gly Lys Thr Ser Glu Arg Phe Leu Phe Lys Gln Leu Asp 
1               5                   10                  15      


Ser Leu Trp Leu Leu Asp Ser Asp Gly Ser Phe Thr Leu Ser Leu His 
            20                  25                  30          


Glu Asp Glu Leu Phe Thr Leu Thr Thr Leu Thr Thr Gly Arg Lys Gly 
        35                  40                  45              


Ser Tyr Pro Leu Pro Pro Lys Ser Gln Pro Phe Pro Ser Thr Tyr Lys 
    50                  55                  60                  


Asp Asp Phe Asn Val Gly Pro Ile 
65                  70          


<210>  5745
<211>  404
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5745

Xaa Leu Leu Ser Ala Ser Trp Gln Arg Arg Ala Lys Ala Met Thr Ala 
1               5                   10                  15      


Ala Ala Gly Ser Ala Gly Arg Ala Ala Val Pro Leu Leu Leu Cys Ala 
            20                  25                  30          


Leu Leu Ala Pro Gly Gly Ala Tyr Val Leu Asp Asp Ser Asp Gly Leu 
        35                  40                  45              


Gly Arg Glu Phe Asp Gly Ile Gly Ala Val Ser Gly Gly Gly Ala Thr 
    50                  55                  60                  


Ser Arg Leu Leu Val Asn Tyr Pro Glu Pro Tyr Arg Ser Gln Ile Leu 
65                  70                  75                  80  


Asp Tyr Leu Phe Lys Pro Asn Phe Gly Ala Ser Leu His Ile Leu Lys 
                85                  90                  95      


Val Glu Ile Gly Gly Asp Gly Gln Thr Thr Asp Gly Thr Glu Pro Ser 
            100                 105                 110         


His Met His Tyr Ala Leu Asp Glu Asn Tyr Phe Arg Gly Tyr Glu Trp 
        115                 120                 125             


Trp Leu Met Lys Glu Ala Lys Lys Arg Asn Pro Asn Ile Thr Leu Ile 
    130                 135                 140                 


Gly Leu Pro Trp Ser Phe Pro Gly Trp Leu Gly Lys Gly Phe Asp Trp 
145                 150                 155                 160 


Pro Tyr Val Asn Leu Gln Leu Thr Ala Tyr Tyr Val Val Thr Trp Ile 
                165                 170                 175     


Val Gly Ala Lys Arg Tyr His Asp Leu Asp Ile Asp Tyr Ile Gly Ile 
            180                 185                 190         


Trp Asn Glu Arg Ser Tyr Asn Ala Asn Tyr Ile Lys Ile Leu Arg Lys 
        195                 200                 205             


Met Leu Asn Tyr Gln Gly Leu Gln Arg Val Lys Ile Ile Ala Ser Asp 
    210                 215                 220                 


Asn Leu Trp Glu Ser Ile Ser Ala Ser Met Leu Leu Asp Ala Glu Leu 
225                 230                 235                 240 


Phe Lys Val Val Asp Val Ile Gly Ala His Tyr Pro Gly Thr His Ser 
                245                 250                 255     


Ala Lys Asp Ala Lys Leu Thr Gly Lys Lys Leu Trp Ser Ser Glu Asp 
            260                 265                 270         


Phe Ser Thr Leu Asn Ser Asp Met Gly Ala Gly Cys Trp Gly Arg Ile 
        275                 280                 285             


Leu Asn Gln Asn Tyr Ile Asn Gly Tyr Met Thr Ser Thr Ile Ala Trp 
    290                 295                 300                 


Asn Leu Val Ala Ser Tyr Tyr Glu Gln Leu Pro Tyr Gly Arg Cys Gly 
305                 310                 315                 320 


Leu Met Thr Ala Gln Glu Pro Trp Ser Gly His Tyr Val Val Glu Ser 
                325                 330                 335     


Pro Val Trp Val Ser Ala His Thr Thr Gln Phe Thr Gln Pro Gly Trp 
            340                 345                 350         


Tyr Tyr Leu Lys Thr Val Gly His Leu Glu Lys Gly Gly Ser Tyr Val 
        355                 360                 365             


Ala Leu Thr Asp Gly Leu Gly Asn Leu Thr Ile Ile Ile Glu Thr Met 
    370                 375                 380                 


Val Asn Phe Cys Cys Cys Tyr Trp Ile Asn Ser Leu Leu Tyr Tyr Trp 
385                 390                 395                 400 


Lys Asn Lys Ile 
                


<210>  5746
<211>  78
<212>  PRT
<213>  Homo Sapiens

<400>  5746

Met Ala Ala Val Val Ala Ala Thr Arg Trp Trp Gln Leu Leu Leu Val 
1               5                   10                  15      


Leu Ser Ala Ala Gly Met Gly Ala Ser Gly Ala Pro Gln Pro Pro Asn 
            20                  25                  30          


Ile Leu Leu Leu Leu Met Asp Asp Glu Ser Leu Pro Pro Pro Arg Ala 
        35                  40                  45              


Ala Gly Ser Pro Arg Trp Ala Pro Val Leu Pro Asp Gly Cys Leu Cys 
    50                  55                  60                  


Pro Leu Glu Asn Ala Glu Arg Arg Ser Gly Val Pro Lys Val 
65                  70                  75              


<210>  5747
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  5747

Met Ala Ala Val Val Ala Ala Thr Arg Trp Trp Gln Leu Leu Leu Val 
1               5                   10                  15      


Leu Ser Ala Ala Gly Met Gly Ala Ser Gly Ala Pro Gln Pro Pro Asn 
            20                  25                  30          


Ile Leu Leu Leu Leu Met Asp Asp Glu Ser Leu Pro Pro Pro Arg Ala 
        35                  40                  45              


Ala Gly Ser Pro Arg Trp Ala Pro Val Leu Pro Asp Gly Cys Leu Cys 
    50                  55                  60                  


Pro Leu Glu Asn Ala Glu Arg Ser Asp Cys Phe Pro Glu His Ala Leu 
65                  70                  75                  80  


Gln Arg Pro Gly Val Arg Val Leu Thr Ala Val Ala Gly Pro Phe Ser 
                85                  90                  95      


Ala Leu Ser Gly Ile Ser Leu Leu Lys Ile Leu Cys Phe Arg Ile Ser 
            100                 105                 110         


Ser Phe His Phe 
        115     


<210>  5748
<211>  522
<212>  PRT
<213>  Homo Sapiens

<400>  5748

Met Ala Ala Val Val Ala Ala Thr Arg Trp Trp Gln Leu Leu Leu Val 
1               5                   10                  15      


Leu Ser Ala Ala Gly Met Gly Ala Ser Gly Ala Pro Gln Pro Pro Asn 
            20                  25                  30          


Ile Leu Leu Leu Leu Met Asp Asp Met Gly Trp Gly Asp Leu Gly Val 
        35                  40                  45              


Tyr Gly Glu Pro Ser Arg Glu Thr Pro Asn Leu Asp Arg Met Ala Ala 
    50                  55                  60                  


Glu Gly Leu Leu Phe Pro Asn Phe Tyr Ser Ala Asn Pro Leu Cys Ser 
65                  70                  75                  80  


Pro Ser Arg Ala Ala Leu Leu Thr Gly Arg Leu Pro Ile Arg Asn Gly 
                85                  90                  95      


Phe Tyr Thr Thr Asn Ala His Ala Arg Asn Ala Tyr Thr Pro Gln Glu 
            100                 105                 110         


Ile Val Gly Gly Ile Pro Asp Ser Glu Gln Leu Leu Pro Glu Leu Leu 
        115                 120                 125             


Lys Lys Ala Gly Tyr Val Ser Lys Ile Val Gly Lys Trp His Leu Gly 
    130                 135                 140                 


His Arg Pro Gln Phe His Pro Leu Lys His Gly Phe Asp Glu Trp Phe 
145                 150                 155                 160 


Gly Ser Pro Asn Cys His Phe Gly Pro Tyr Asp Asn Lys Ala Arg Pro 
                165                 170                 175     


Asn Ile Pro Val Tyr Arg Asp Trp Glu Met Val Gly Arg Tyr Tyr Glu 
            180                 185                 190         


Glu Phe Pro Ile Asn Leu Lys Thr Gly Glu Ala Asn Leu Thr Gln Ile 
        195                 200                 205             


Tyr Leu Gln Glu Ala Leu Asp Phe Ile Lys Arg Gln Ala Arg His His 
    210                 215                 220                 


Pro Phe Phe Leu Tyr Trp Ala Val Asp Ala Thr His Ala Pro Val Tyr 
225                 230                 235                 240 


Ala Ser Lys Pro Phe Leu Gly Thr Ser Gln Arg Gly Arg Tyr Gly Asp 
                245                 250                 255     


Ala Val Arg Glu Ile Asp Asp Ser Ile Gly Lys Ile Leu Glu Leu Leu 
            260                 265                 270         


Gln Asp Leu His Val Ala Asp Asn Thr Phe Val Phe Phe Thr Ser Asp 
        275                 280                 285             


Asn Gly Ala Ala Leu Ile Ser Ala Pro Glu Gln Gly Gly Ser Asn Gly 
    290                 295                 300                 


Pro Phe Leu Cys Gly Lys Gln Thr Thr Phe Glu Gly Gly Met Arg Glu 
305                 310                 315                 320 


Pro Ala Leu Ala Trp Trp Pro Gly His Val Thr Ala Gly Gln Val Ser 
                325                 330                 335     


His Gln Leu Gly Ser Ile Met Asp Leu Phe Thr Thr Ser Leu Ala Leu 
            340                 345                 350         


Ala Gly Leu Thr Pro Pro Ser Asp Arg Ala Ile Asp Gly Leu Asn Leu 
        355                 360                 365             


Leu Pro Thr Leu Leu Gln Gly Arg Leu Met Asp Arg Pro Ile Phe Tyr 
    370                 375                 380                 


Tyr Arg Gly Asp Thr Leu Met Ala Ala Thr Leu Gly Gln His Lys Ala 
385                 390                 395                 400 


His Phe Trp Thr Trp Thr Asn Ser Trp Glu Asn Phe Arg Gln Gly Ile 
                405                 410                 415     


Asp Phe Cys Pro Gly Gln Asn Val Ser Gly Val Thr Thr His Asn Leu 
            420                 425                 430         


Glu Asp His Thr Lys Leu Pro Leu Ile Phe His Leu Gly Arg Asp Pro 
        435                 440                 445             


Gly Glu Arg Phe Pro Leu Ser Phe Ala Ser Ala Glu Tyr Gln Glu Ala 
    450                 455                 460                 


Leu Ser Arg Ile Thr Ser Val Val Gln Gln His Gln Glu Ala Leu Val 
465                 470                 475                 480 


Pro Ala Gln Pro Gln Leu Asn Val Cys Asn Trp Ala Val Met Asn Trp 
                485                 490                 495     


Ala Pro Pro Gly Cys Glu Lys Leu Gly Lys Cys Leu Thr Pro Pro Glu 
            500                 505                 510         


Ser Ile Pro Lys Lys Cys Leu Trp Ser His 
        515                 520         


<210>  5749
<211>  170
<212>  PRT
<213>  Homo Sapiens

<400>  5749

Met Thr Gly Thr Ala Ser Ser Leu Ala Ala Arg Ala Ala Leu Leu Thr 
1               5                   10                  15      


Gly Arg Leu Pro Ile Arg Asn Gly Phe Tyr Thr Thr Asn Ala His Ala 
            20                  25                  30          


Arg Asn Ala Tyr Thr Pro Gln Glu Ile Val Gly Gly Ile Pro Asp Ser 
        35                  40                  45              


Glu Gln Leu Leu Pro Glu Leu Leu Lys Lys Ala Gly Tyr Val Ser Lys 
    50                  55                  60                  


Ile Val Gly Lys Trp His Leu Gly His Arg Pro Gln Phe His Pro Leu 
65                  70                  75                  80  


Lys His Gly Phe Asp Glu Trp Phe Gly Ser Pro Asn Cys His Phe Gly 
                85                  90                  95      


Pro Tyr Asp Asn Lys Ala Arg Pro Asn Ile Pro Val Tyr Arg Asp Trp 
            100                 105                 110         


Glu Met Val Gly Arg Tyr Tyr Glu Glu Phe Pro Ile Asn Leu Lys Thr 
        115                 120                 125             


Gly Glu Ala Asn Leu Thr Gln Ile Tyr Leu Gln Glu Ala Leu Asp Phe 
    130                 135                 140                 


Ile Lys Arg Gln Ala Arg His His Pro Phe Phe Leu Tyr Trp Ala Val 
145                 150                 155                 160 


Asp Ala Thr His Ala Pro Val Tyr Ala Ser 
                165                 170 


<210>  5750
<211>  51
<212>  PRT
<213>  Homo Sapiens

<400>  5750

Ser Ala Ala Gly Met Gly Ala Ser Gly Ala Pro Gln Pro Pro Asn Ile 
1               5                   10                  15      


Leu Leu Leu Leu Met Asp Asp Met His Val Phe Arg Gly Gln Leu Leu 
            20                  25                  30          


Arg Ala Cys Arg Cys Trp Cys Gln Ala Gly Arg Arg Gln Thr Asp Thr 
        35                  40                  45              


Phe Pro Thr 
    50      


<210>  5751
<211>  69
<212>  PRT
<213>  Homo Sapiens

<400>  5751

Ser Ala Ala Gly Met Gly Ala Ser Gly Ala Pro Gln Pro Pro Asn Ile 
1               5                   10                  15      


Leu Leu Leu Leu Met Asp Asp Arg Gly Arg His Cys Ser Gln Asp Gly 
            20                  25                  30          


Tyr Pro Ser Ala Met Ala Ser Thr Pro Pro Thr Pro Met Pro Glu Thr 
        35                  40                  45              


Pro Thr His Arg Arg Arg Leu Trp Ala Ala Ser Gln Thr Arg Ser Ser 
    50                  55                  60                  


Ser Cys Arg Ser Phe 
65                  


<210>  5752
<211>  202
<212>  PRT
<213>  Homo Sapiens

<400>  5752

Met Arg Arg Lys Glu Lys Arg Leu Leu Gln Ala Val Ala Leu Val Leu 
1               5                   10                  15      


Ala Ala Leu Val Leu Leu Pro Asn Val Gly Leu Trp Ala Leu Tyr Arg 
            20                  25                  30          


Glu Arg Gln Pro Asp Gly Thr Pro Gly Gly Ser Gly Ala Ala Val Ala 
        35                  40                  45              


Pro Ala Ala Gly Gln Gly Ser His Ser Arg Gln Lys Lys Thr Phe Phe 
    50                  55                  60                  


Leu Gly Asp Gly Gln Lys Leu Lys Asp Trp His Asp Lys Glu Ala Ile 
65                  70                  75                  80  


Arg Arg Asp Ala Gln Arg Val Gly Asn Gly Glu Gln Gly Arg Pro Tyr 
                85                  90                  95      


Pro Met Thr Asp Ala Glu Arg Val Asp Gln Ala Tyr Arg Glu Asn Gly 
            100                 105                 110         


Phe Asn Ile Tyr Val Ser Asp Lys Ile Ser Leu Asn Arg Ser Leu Pro 
        115                 120                 125             


Asp Ile Arg His Pro Asn Cys Asn Ser Lys Arg Tyr Leu Glu Thr Leu 
    130                 135                 140                 


Pro Asn Thr Ser Ile Ile Ile Pro Phe His Asn Glu Gly Trp Ser Ser 
145                 150                 155                 160 


Leu Leu Arg Thr Val His Ser Val Leu Asn Arg Ser Pro Pro Glu Leu 
                165                 170                 175     


Val Ala Glu Ile Val Leu Val Asp Asp Phe Ser Asp Arg Asp Leu Pro 
            180                 185                 190         


Thr Ala Ser Thr Pro Ser Pro Phe Val Cys 
        195                 200         


<210>  5753
<211>  541
<212>  PRT
<213>  Homo Sapiens

<400>  5753

Met Arg Arg Lys Glu Lys Arg Leu Leu Gln Ala Val Ala Leu Val Leu 
1               5                   10                  15      


Ala Ala Leu Val Leu Leu Pro Asn Val Gly Leu Trp Ala Leu Tyr Arg 
            20                  25                  30          


Glu Arg Gln Pro Asp Gly Thr Pro Gly Gly Ser Gly Ala Ala Val Ala 
        35                  40                  45              


Pro Ala Ala Gly Gln Gly Ser His Ser Arg Gln Lys Lys Thr Phe Phe 
    50                  55                  60                  


Leu Gly Asp Gly Gln Lys Leu Lys Asp Trp His Asp Lys Glu Ala Ile 
65                  70                  75                  80  


Arg Arg Asp Ala Gln Arg Val Gly Asn Gly Glu Gln Gly Arg Pro Tyr 
                85                  90                  95      


Pro Met Thr Asp Ala Glu Arg Val Asp Gln Ala Tyr Arg Glu Asn Gly 
            100                 105                 110         


Phe Asn Ile Tyr Val Ser Asp Lys Ile Ser Leu Asn Arg Ser Leu Pro 
        115                 120                 125             


Asp Ile Arg His Pro Asn Cys Asn Ser Lys Arg Tyr Leu Glu Thr Leu 
    130                 135                 140                 


Pro Asn Thr Ser Ile Ile Ile Pro Phe His Asn Glu Gly Trp Ser Ser 
145                 150                 155                 160 


Leu Leu Arg Thr Val His Ser Val Leu Asn Arg Ser Pro Pro Glu Leu 
                165                 170                 175     


Val Ala Glu Ile Val Leu Val Asp Asp Phe Ser Asp Arg Asp Arg Ile 
            180                 185                 190         


Ala Arg Asn Arg Lys Thr Ile Val Cys Pro Met Ile Asp Val Ile Asp 
        195                 200                 205             


His Asp Asp Phe Arg Tyr Glu Thr Gln Ala Gly Asp Ala Met Arg Gly 
    210                 215                 220                 


Ala Phe Asp Trp Glu Met Tyr Tyr Lys Arg Ile Pro Ile Pro Pro Glu 
225                 230                 235                 240 


Leu Gln Lys Ala Asp Pro Ser Asp Pro Phe Glu Ser Pro Val Met Ala 
                245                 250                 255     


Gly Gly Leu Phe Ala Val Asp Arg Lys Trp Phe Trp Glu Leu Gly Gly 
            260                 265                 270         


Tyr Asp Pro Gly Leu Glu Ile Trp Gly Gly Glu Gln Tyr Glu Ile Ser 
        275                 280                 285             


Phe Lys Val Trp Met Cys Gly Gly Arg Met Glu Asp Ile Pro Cys Ser 
    290                 295                 300                 


Arg Val Gly His Ile Tyr Arg Lys Tyr Val Pro Tyr Lys Val Pro Ala 
305                 310                 315                 320 


Gly Val Ser Leu Ala Arg Asn Leu Lys Arg Val Ala Glu Val Trp Met 
                325                 330                 335     


Asp Glu Tyr Ala Glu Tyr Ile Tyr Gln Arg Arg Pro Glu Tyr Arg His 
            340                 345                 350         


Leu Ser Ala Gly Asp Val Ala Val Gln Lys Lys Leu Arg Ser Ser Leu 
        355                 360                 365             


Asn Cys Lys Ser Phe Lys Trp Phe Met Thr Lys Ile Ala Trp Asp Leu 
    370                 375                 380                 


Pro Lys Phe Tyr Pro Pro Val Glu Pro Pro Ala Ala Ala Trp Gly Glu 
385                 390                 395                 400 


Ile Arg Asn Val Gly Thr Gly Leu Cys Ala Asp Thr Lys His Gly Ala 
                405                 410                 415     


Leu Gly Ser Pro Leu Arg Leu Glu Gly Cys Val Arg Gly Arg Gly Glu 
            420                 425                 430         


Ala Ala Trp Asn Asn Met Gln Val Phe Thr Phe Thr Trp Arg Glu Asp 
        435                 440                 445             


Ile Arg Pro Gly Asp Pro Gln His Thr Lys Lys Phe Cys Phe Asp Ala 
    450                 455                 460                 


Ile Ser His Thr Ser Pro Val Thr Leu Tyr Asp Cys His Ser Met Lys 
465                 470                 475                 480 


Gly Asn Gln Leu Trp Lys Tyr Arg Lys Asp Lys Thr Leu Tyr His Pro 
                485                 490                 495     


Val Ser Gly Ser Cys Met Asp Cys Ser Glu Ser Asp His Arg Ile Phe 
            500                 505                 510         


Met Asn Thr Cys Asn Pro Ser Ser Leu Thr Gln Gln Trp Leu Phe Glu 
        515                 520                 525             


His Thr Asn Ser Thr Val Leu Glu Lys Phe Asn Arg Asn 
    530                 535                 540     


<210>  5754
<211>  603
<212>  PRT
<213>  Homo Sapiens

<400>  5754

Met Arg Arg Lys Glu Lys Arg Leu Leu Gln Ala Val Ala Leu Val Leu 
1               5                   10                  15      


Ala Ala Leu Val Leu Leu Pro Asn Val Gly Leu Trp Ala Leu Tyr Arg 
            20                  25                  30          


Glu Arg Gln Pro Asp Gly Thr Pro Gly Gly Ser Gly Ala Ala Val Ala 
        35                  40                  45              


Pro Ala Ala Gly Gln Gly Ser His Ser Arg Gln Lys Lys Thr Phe Phe 
    50                  55                  60                  


Leu Gly Asp Gly Gln Lys Leu Lys Asp Trp His Asp Lys Glu Ala Ile 
65                  70                  75                  80  


Arg Arg Asp Ala Gln Arg Val Gly Asn Gly Glu Gln Gly Arg Pro Tyr 
                85                  90                  95      


Pro Met Thr Asp Ala Glu Arg Val Asp Gln Ala Tyr Arg Glu Asn Gly 
            100                 105                 110         


Phe Asn Ile Tyr Val Ser Asp Lys Ile Ser Leu Asn Arg Ser Leu Pro 
        115                 120                 125             


Asp Ile Arg His Pro Asn Cys Asn Ser Lys Arg Tyr Leu Glu Thr Leu 
    130                 135                 140                 


Pro Asn Thr Ser Ile Ile Ile Pro Phe His Asn Glu Gly Trp Ser Ser 
145                 150                 155                 160 


Leu Leu Arg Thr Val His Ser Val Leu Asn Arg Ser Pro Pro Glu Leu 
                165                 170                 175     


Val Ala Glu Ile Val Leu Val Asp Asp Phe Ser Asp Arg Glu His Leu 
            180                 185                 190         


Lys Lys Pro Leu Glu Asp Tyr Met Ala Leu Phe Pro Ser Val Arg Ile 
        195                 200                 205             


Leu Arg Thr Lys Lys Arg Glu Gly Leu Ile Arg Thr Arg Met Leu Gly 
    210                 215                 220                 


Ala Ser Val Ala Thr Gly Asp Val Ile Thr Phe Leu Asp Ser His Cys 
225                 230                 235                 240 


Glu Ala Asn Val Asn Trp Leu Pro Pro Leu Leu Asp Arg Ile Ala Arg 
                245                 250                 255     


Asn Arg Lys Thr Ile Val Cys Pro Met Ile Asp Val Ile Asp His Asp 
            260                 265                 270         


Asp Phe Arg Tyr Glu Thr Gln Ala Gly Asp Ala Met Arg Gly Ala Phe 
        275                 280                 285             


Asp Trp Glu Met Tyr Tyr Lys Arg Ile Pro Ile Pro Pro Glu Leu Gln 
    290                 295                 300                 


Lys Ala Asp Pro Ser Asp Pro Phe Glu Ser Pro Val Met Ala Gly Gly 
305                 310                 315                 320 


Leu Phe Ala Val Asp Arg Lys Trp Phe Trp Glu Leu Gly Gly Tyr Asp 
                325                 330                 335     


Pro Gly Leu Glu Ile Trp Gly Gly Glu Gln Tyr Glu Ile Ser Phe Lys 
            340                 345                 350         


Val Trp Met Cys Gly Gly Arg Met Glu Asp Ile Pro Cys Ser Arg Val 
        355                 360                 365             


Gly His Ile Tyr Arg Lys Tyr Val Pro Tyr Lys Val Pro Ala Gly Val 
    370                 375                 380                 


Ser Leu Ala Arg Asn Leu Lys Arg Val Ala Glu Val Trp Met Asp Glu 
385                 390                 395                 400 


Tyr Ala Glu Tyr Ile Tyr Gln Arg Arg Pro Glu Tyr Arg His Leu Ser 
                405                 410                 415     


Ala Gly Asp Val Ala Val Gln Lys Lys Leu Arg Ser Ser Leu Asn Cys 
            420                 425                 430         


Lys Ser Phe Lys Trp Phe Met Thr Lys Ile Ala Trp Asp Leu Pro Lys 
        435                 440                 445             


Phe Tyr Pro Pro Val Glu Pro Pro Ala Ala Ala Trp Gly Glu Ile Arg 
    450                 455                 460                 


Asn Val Gly Thr Gly Leu Cys Ala Asp Thr Lys His Gly Ala Leu Gly 
465                 470                 475                 480 


Ser Pro Leu Arg Leu Glu Gly Cys Val Arg Gly Arg Gly Glu Ala Ala 
                485                 490                 495     


Trp Asn Asn Met Gln Val Phe Thr Phe Thr Trp Arg Glu Asp Ile Arg 
            500                 505                 510         


Pro Gly Asp Pro Gln His Thr Lys Lys Phe Cys Phe Asp Ala Ile Ser 
        515                 520                 525             


His Thr Ser Pro Val Thr Leu Tyr Asp Cys His Ser Met Lys Gly Asn 
    530                 535                 540                 


Gln Leu Trp Lys Tyr Arg Lys Asp Lys Thr Leu Tyr His Pro Val Ser 
545                 550                 555                 560 


Gly Ser Cys Met Asp Cys Ser Glu Ser Asp His Arg Ile Phe Met Asn 
                565                 570                 575     


Thr Cys Asn Pro Ser Ser Leu Thr Gln Gln Trp Leu Phe Glu His Thr 
            580                 585                 590         


Asn Ser Thr Val Leu Glu Lys Phe Asn Arg Asn 
        595                 600             


<210>  5755
<211>  366
<212>  PRT
<213>  Homo Sapiens

<400>  5755

Met Arg Arg Lys Glu Lys Arg Leu Leu Gln Ala Val Ala Leu Val Leu 
1               5                   10                  15      


Ala Ala Leu Val Leu Leu Pro Asn Val Gly Leu Trp Ala Leu Tyr Arg 
            20                  25                  30          


Glu Arg Gln Pro Asp Gly Thr Pro Gly Gly Ser Gly Ala Ala Val Ala 
        35                  40                  45              


Pro Ala Ala Gly Gln Gly Ser His Ser Arg Gln Lys Lys Thr Phe Phe 
    50                  55                  60                  


Leu Gly Asp Gly Gln Lys Leu Lys Asp Trp His Asp Lys Glu Ala Ile 
65                  70                  75                  80  


Arg Arg Asp Ala Gln Arg Val Gly Asn Gly Glu Gln Gly Arg Pro Tyr 
                85                  90                  95      


Pro Met Thr Asp Ala Glu Arg Val Asp Gln Ala Tyr Arg Glu Asn Gly 
            100                 105                 110         


Phe Asn Ile Tyr Val Ser Asp Lys Ile Ser Leu Asn Arg Ser Leu Pro 
        115                 120                 125             


Asp Ile Arg His Pro Asn Cys Asn Ser Lys Arg Tyr Leu Glu Thr Leu 
    130                 135                 140                 


Pro Asn Thr Ser Ile Ile Ile Pro Phe His Asn Glu Gly Trp Ser Ser 
145                 150                 155                 160 


Leu Leu Arg Thr Val His Ser Val Leu Asn Arg Ser Pro Pro Glu Leu 
                165                 170                 175     


Val Ala Glu Ile Val Leu Val Asp Asp Phe Ser Asp Arg Glu His Leu 
            180                 185                 190         


Lys Lys Pro Leu Glu Asp Tyr Met Ala Leu Phe Pro Ser Val Arg Ile 
        195                 200                 205             


Leu Arg Thr Lys Lys Arg Glu Gly Leu Ile Arg Thr Arg Met Leu Gly 
    210                 215                 220                 


Ala Ser Val Ala Thr Gly Asp Val Ile Thr Phe Leu Asp Ser His Cys 
225                 230                 235                 240 


Glu Ala Asn Val Asn Trp Leu Pro Pro Leu Leu Asp Arg Ile Ala Arg 
                245                 250                 255     


Asn Arg Lys Thr Ile Val Cys Pro Met Ile Asp Val Ile Asp His Asp 
            260                 265                 270         


Asp Phe Arg Tyr Glu Thr Gln Ala Gly Asp Ala Met Arg Gly Ala Phe 
        275                 280                 285             


Asp Trp Glu Met Tyr Tyr Lys Arg Ile Pro Ile Pro Pro Glu Leu Gln 
    290                 295                 300                 


Lys Ala Asp Pro Ser Asp Pro Phe Glu Ser Pro Val Met Ala Gly Gly 
305                 310                 315                 320 


Leu Phe Ala Val Asp Arg Lys Trp Phe Trp Glu Leu Gly Gly Tyr Asp 
                325                 330                 335     


Pro Gly Leu Glu Ile Trp Gly Gly Glu Gln Tyr Glu Ile Ser Phe Lys 
            340                 345                 350         


Val Ser Gln Leu Ser Arg Arg Pro Val Leu Gly Thr Ala Ser 
        355                 360                 365     


<210>  5756
<211>  581
<212>  PRT
<213>  Homo Sapiens

<400>  5756

Met Trp Gly Arg Thr Ala Arg Arg Arg Cys Pro Arg Glu Leu Arg Arg 
1               5                   10                  15      


Gly Arg Glu Ala Leu Leu Val Leu Leu Ala Leu Leu Ala Leu Ala Gly 
            20                  25                  30          


Leu Gly Ser Val Leu Arg Ala Gln Arg Gly Ala Gly Ala Gly Ala Ala 
        35                  40                  45              


Glu Pro Gly Pro Pro Arg Thr Pro Arg Pro Gly Arg Arg Glu Pro Val 
    50                  55                  60                  


Met Pro Arg Pro Pro Val Pro Ala Asn Ala Leu Gly Ala Arg Gly Glu 
65                  70                  75                  80  


Ala Val Arg Leu Gln Leu Gln Gly Glu Glu Leu Arg Leu Gln Glu Glu 
                85                  90                  95      


Ser Val Arg Leu His Gln Ile Asn Ile Tyr Leu Ser Asp Arg Ile Ser 
            100                 105                 110         


Leu His Arg Arg Leu Pro Glu Arg Trp Asn Pro Leu Cys Lys Glu Lys 
        115                 120                 125             


Lys Tyr Asp Tyr Asp Asn Leu Pro Arg Thr Ser Val Ile Ile Ala Phe 
    130                 135                 140                 


Tyr Asn Glu Ala Trp Ser Thr Leu Leu Arg Thr Val Tyr Ser Val Leu 
145                 150                 155                 160 


Glu Thr Ser Pro Asp Ile Leu Leu Glu Glu Val Ile Leu Val Asp Asp 
                165                 170                 175     


Tyr Ser Asp Arg Glu His Leu Lys Glu Arg Leu Ala Asn Glu Leu Ser 
            180                 185                 190         


Gly Leu Pro Lys Val Arg Leu Ile Arg Ala Asn Lys Arg Glu Gly Leu 
        195                 200                 205             


Val Arg Ala Arg Leu Leu Gly Ala Ser Ala Ala Arg Gly Asp Val Leu 
    210                 215                 220                 


Thr Phe Leu Asp Cys His Cys Glu Cys His Glu Gly Trp Leu Glu Pro 
225                 230                 235                 240 


Leu Leu Gln Arg Ile His Glu Glu Glu Ser Ala Val Val Cys Pro Val 
                245                 250                 255     


Ile Asp Val Ile Asp Trp Asn Thr Phe Glu Tyr Leu Gly Asn Ser Gly 
            260                 265                 270         


Glu Pro Gln Ile Gly Gly Phe Asp Trp Arg Leu Val Phe Thr Trp His 
        275                 280                 285             


Thr Val Pro Glu Arg Glu Arg Ile Arg Met Gln Ser Pro Val Asp Val 
    290                 295                 300                 


Ile Arg Ser Pro Thr Met Ala Gly Gly Leu Phe Ala Val Ser Lys Lys 
305                 310                 315                 320 


Tyr Phe Glu Tyr Leu Gly Ser Tyr Asp Thr Gly Met Glu Val Trp Gly 
                325                 330                 335     


Gly Glu Asn Leu Glu Phe Ser Phe Arg Ile Trp Gln Cys Gly Gly Val 
            340                 345                 350         


Leu Glu Thr His Pro Cys Ser His Val Gly His Val Phe Pro Lys Gln 
        355                 360                 365             


Ala Pro Tyr Ser Arg Asn Lys Ala Leu Ala Asn Ser Val Arg Ala Ala 
    370                 375                 380                 


Glu Val Trp Met Asp Glu Phe Lys Glu Leu Tyr Tyr His Arg Asn Pro 
385                 390                 395                 400 


Arg Ala Arg Leu Glu Pro Phe Gly Asp Val Thr Glu Arg Lys Gln Leu 
                405                 410                 415     


Arg Asp Lys Leu Gln Cys Lys Asp Phe Lys Trp Phe Leu Glu Thr Val 
            420                 425                 430         


Tyr Pro Glu Leu His Val Pro Glu Asp Arg Pro Gly Phe Phe Gly Met 
        435                 440                 445             


Leu Gln Asn Lys Gly Leu Thr Asp Tyr Cys Phe Asp Tyr Asn Pro Pro 
    450                 455                 460                 


Asp Glu Asn Gln Ile Val Gly His Gln Val Ile Leu Tyr Leu Cys His 
465                 470                 475                 480 


Gly Met Gly Gln Asn Gln Phe Phe Glu Tyr Thr Ser Gln Lys Glu Ile 
                485                 490                 495     


Arg Tyr Asn Thr His Gln Pro Glu Gly Cys Ile Ala Val Glu Ala Gly 
            500                 505                 510         


Met Asp Thr Leu Ile Met His Leu Cys Glu Glu Thr Ala Pro Glu Asn 
        515                 520                 525             


Gln Lys Phe Ile Leu Gln Glu Asp Gly Ser Leu Phe His Glu Gln Ser 
    530                 535                 540                 


Lys Lys Cys Val Gln Ala Ala Arg Lys Glu Ser Ser Asp Ser Phe Val 
545                 550                 555                 560 


Pro Leu Leu Arg Asp Cys Thr Asn Ser Asp His Gln Lys Trp Phe Phe 
                565                 570                 575     


Lys Glu Arg Met Leu 
            580     


<210>  5757
<211>  31
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5757

Xaa Ile Asn Ile Tyr Leu Ser Asp Arg Ile Ser Leu His Arg Arg Leu 
1               5                   10                  15      


Pro Glu Arg Trp Asn Pro Leu Ala Pro Glu Gly Ala Leu Gly Gln 
            20                  25                  30      


<210>  5758
<211>  141
<212>  PRT
<213>  Homo Sapiens

<400>  5758

Ala Leu Pro Glu Val Arg His Pro Leu Cys Leu Gln Gln His Pro Gln 
1               5                   10                  15      


Asp Ser Leu Pro Thr Ala Ser Val Ile Leu Cys Phe His Asp Glu Ala 
            20                  25                  30          


Trp Ser Thr Leu Leu Arg Thr Val His Ser Ile Leu Asp Thr Val Pro 
        35                  40                  45              


Arg Ala Phe Leu Lys Glu Ile Ile Leu Val Asp Asp Leu Ser Gln Gln 
    50                  55                  60                  


Gly Ser His Gly Phe Pro Pro Gly Ser Ser Gly Thr Thr Gln Val Cys 
65                  70                  75                  80  


Ser Gln Arg Ile Cys Gly Gln Ala Gly Gly Gly Glu Val Thr Gln Glu 
                85                  90                  95      


Gln Gln Glu Ala Gly Cys His Gln Gly Pro Asp Ala Gly Gly His Gln 
            100                 105                 110         


Ser His Arg Gly Cys Ala Arg Leu His Gly Cys Pro Leu Arg Val Pro 
        115                 120                 125             


Pro Arg Leu Ala Gly Ala Pro Pro Gln Gln Asn Ser Trp 
    130                 135                 140     


<210>  5759
<211>  196
<212>  PRT
<213>  Homo Sapiens

<400>  5759

Met Glu Arg Leu Gln Leu Gln Arg Arg Leu Gly Cys Arg Thr Phe His 
1               5                   10                  15      


Trp Phe Leu Ala Asn Val Tyr Pro Glu Leu Tyr Pro Ser Glu Pro Arg 
            20                  25                  30          


Pro Ser Phe Ser Gly Lys Leu His Asn Thr Gly Leu Gly Leu Cys Ala 
        35                  40                  45              


Asp Cys Gln Ala Glu Gly Asp Ile Leu Gly Cys Pro Met Val Leu Ala 
    50                  55                  60                  


Pro Cys Ser Asp Ser Arg Gln Gln Gln Tyr Leu Gln His Thr Ser Arg 
65                  70                  75                  80  


Lys Glu Ile His Phe Gly Ser Pro Gln His Leu Cys Phe Ala Val Arg 
                85                  90                  95      


Gln Glu Gln Val Ile Leu Gln Asn Cys Thr Glu Glu Gly Leu Ala Ile 
            100                 105                 110         


His Gln Gln His Trp Asp Phe Gln Glu Asn Gly Met Ile Val His Ile 
        115                 120                 125             


Leu Ser Gly Lys Cys Met Glu Ala Val Val Gln Glu Asn Asn Lys Asp 
    130                 135                 140                 


Leu Tyr Leu Arg Pro Cys Asp Glu Lys Pro Ala Ser Ser Gly Val Leu 
145                 150                 155                 160 


Thr Arg Ser Met Leu Trp Met Asn Asp Glu Cys Gln Cys Gln Lys Glu 
                165                 170                 175     


Lys Arg Ile Leu Ala Ile Lys Ile Gln Leu Gln Val Asn Leu Lys Ser 
            180                 185                 190         


Leu Tyr Ile Ser 
        195     


<210>  5760
<211>  639
<212>  PRT
<213>  Homo Sapiens

<400>  5760

Met Leu Leu Arg Lys Arg Tyr Arg His Arg Pro Cys Arg Leu Gln Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Met Leu Gly Cys Val Leu Met Met Val Ala Met 
            20                  25                  30          


Leu His Pro Pro His His Thr Leu His Gln Thr Val Thr Ala Gln Ala 
        35                  40                  45              


Ser Lys His Ser Pro Glu Ala Arg Tyr Arg Leu Asp Phe Gly Glu Ser 
    50                  55                  60                  


Gln Asp Trp Val Leu Glu Ala Glu Asp Glu Gly Glu Glu Tyr Ser Pro 
65                  70                  75                  80  


Leu Glu Gly Leu Pro Pro Phe Ile Ser Leu Arg Glu Asp Gln Leu Leu 
                85                  90                  95      


Val Ala Val Ala Leu Pro Gln Ala Arg Arg Asn Gln Ser Gln Gly Arg 
            100                 105                 110         


Arg Gly Gly Ser Tyr Arg Leu Ile Lys Gln Pro Arg Arg Gln Asp Lys 
        115                 120                 125             


Glu Ala Pro Lys Arg Asp Trp Gly Ala Asp Glu Asp Gly Glu Val Ser 
    130                 135                 140                 


Glu Glu Glu Glu Leu Thr Pro Phe Ser Leu Asp Pro Arg Gly Leu Gln 
145                 150                 155                 160 


Glu Ala Leu Ser Ala Arg Ile Pro Leu Gln Arg Ala Leu Pro Glu Val 
                165                 170                 175     


Arg His Pro Leu Cys Leu Gln Gln His Pro Gln Asp Ser Leu Pro Thr 
            180                 185                 190         


Ala Ser Val Ile Leu Cys Phe His Asp Glu Ala Trp Ser Thr Leu Leu 
        195                 200                 205             


Arg Thr Val His Ser Ile Leu Asp Thr Val Pro Arg Ala Phe Leu Lys 
    210                 215                 220                 


Glu Ile Ile Leu Val Asp Asp Leu Ser Gln Gln Gly Gln Leu Lys Ser 
225                 230                 235                 240 


Ala Leu Ser Glu Tyr Val Ala Arg Leu Glu Gly Val Lys Leu Leu Arg 
                245                 250                 255     


Ser Asn Lys Arg Leu Gly Ala Ile Arg Ala Arg Met Leu Gly Ala Thr 
            260                 265                 270         


Arg Ala Thr Gly Asp Val Leu Val Phe Met Asp Ala His Cys Glu Cys 
        275                 280                 285             


His Pro Gly Trp Leu Glu Pro Leu Leu Ser Arg Ile Ala Gly Asp Arg 
    290                 295                 300                 


Ser Arg Val Val Ser Pro Val Ile Asp Val Ile Asp Trp Lys Thr Phe 
305                 310                 315                 320 


Gln Tyr Tyr Pro Ser Lys Asp Leu Gln Arg Gly Val Leu Asp Trp Lys 
                325                 330                 335     


Leu Asp Phe His Trp Glu Pro Leu Pro Glu His Val Arg Lys Ala Leu 
            340                 345                 350         


Gln Ser Pro Ile Ser Pro Ile Arg Ser Pro Val Val Pro Gly Glu Val 
        355                 360                 365             


Val Ala Met Asp Arg His Tyr Phe Gln Asn Thr Gly Ala Tyr Asp Ser 
    370                 375                 380                 


Leu Met Ser Leu Arg Gly Gly Glu Asn Leu Glu Leu Ser Phe Lys Ala 
385                 390                 395                 400 


Trp Leu Cys Gly Gly Ser Val Glu Ile Leu Pro Cys Ser Arg Val Gly 
                405                 410                 415     


His Ile Tyr Gln Asn Gln Asp Ser His Ser Pro Leu Asp Gln Glu Ala 
            420                 425                 430         


Thr Leu Arg Asn Arg Val Arg Ile Ala Glu Thr Trp Leu Gly Ser Phe 
        435                 440                 445             


Lys Glu Thr Phe Tyr Lys His Ser Pro Glu Ala Phe Ser Leu Ser Lys 
    450                 455                 460                 


Ala Glu Lys Pro Asp Cys Met Glu Arg Leu Gln Leu Gln Arg Arg Leu 
465                 470                 475                 480 


Gly Cys Arg Thr Phe His Trp Phe Leu Ala Asn Val Tyr Pro Glu Leu 
                485                 490                 495     


Tyr Pro Ser Glu Pro Arg Pro Ser Phe Ser Gly Lys Leu His Asn Thr 
            500                 505                 510         


Gly Leu Gly Leu Cys Ala Asp Cys Gln Ala Glu Gly Asp Ile Leu Gly 
        515                 520                 525             


Cys Pro Met Val Leu Ala Pro Cys Ser Asp Ser Arg Gln Gln Gln Tyr 
    530                 535                 540                 


Leu Gln His Thr Ser Arg Lys Glu Ile His Phe Gly Ser Pro Gln His 
545                 550                 555                 560 


Leu Cys Phe Ala Val Arg Gln Glu Gln Val Ile Leu Gln Asn Cys Thr 
                565                 570                 575     


Glu Glu Gly Leu Ala Ile His Gln Gln His Trp Asp Phe Gln Glu Asn 
            580                 585                 590         


Gly Met Ile Val His Ile Leu Ser Gly Lys Cys Met Glu Ala Val Val 
        595                 600                 605             


Gln Glu Asn Asn Lys Asp Leu Tyr Leu Arg Pro Cys Asp Gly Lys Ala 
    610                 615                 620                 


Arg Gln Gln Trp Arg Phe Asp Gln Ile Asn Ala Val Asp Glu Arg 
625                 630                 635                 


<210>  5761
<211>  617
<212>  PRT
<213>  Homo Sapiens

<400>  5761

Met Leu Leu Arg Lys Arg Tyr Arg His Arg Pro Cys Arg Leu Gln Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Met Leu Gly Cys Val Leu Met Met Val Ala Met 
            20                  25                  30          


Leu His Pro Pro His His Thr Leu His Gln Thr Val Thr Ala Gln Ala 
        35                  40                  45              


Ser Lys His Ser Pro Glu Ala Arg Tyr Arg Leu Asp Phe Gly Glu Ser 
    50                  55                  60                  


Gln Asp Trp Val Leu Glu Ala Glu Asp Glu Gly Glu Glu Tyr Ser Pro 
65                  70                  75                  80  


Leu Glu Gly Leu Pro Pro Phe Ile Ser Leu Arg Glu Asp Gln Leu Leu 
                85                  90                  95      


Val Ala Val Ala Leu Pro Gln Ala Arg Arg Asn Gln Ser Gln Gly Arg 
            100                 105                 110         


Arg Gly Gly Ser Tyr Arg Leu Ile Lys Gln Pro Arg Arg Gln Asp Lys 
        115                 120                 125             


Glu Ala Pro Lys Arg Asp Trp Gly Ala Asp Glu Asp Gly Glu Val Ser 
    130                 135                 140                 


Glu Glu Glu Glu Leu Thr Pro Phe Ser Leu Asp Pro Arg Gly Leu Gln 
145                 150                 155                 160 


Glu Ala Leu Ser Ala Arg Ile Pro Leu Gln Arg Ala Leu Pro Glu Val 
                165                 170                 175     


Arg His Pro Leu Cys Leu Gln Gln His Pro Gln Asp Ser Leu Pro Thr 
            180                 185                 190         


Ala Ser Val Ile Leu Cys Phe His Asp Glu Ala Trp Ser Thr Leu Leu 
        195                 200                 205             


Arg Thr Val His Ser Ile Leu Asp Thr Val Pro Arg Ala Phe Leu Lys 
    210                 215                 220                 


Glu Ile Ile Leu Val Asp Asp Leu Ser Gln Gln Gly Gln Leu Lys Ser 
225                 230                 235                 240 


Ala Leu Ser Glu Tyr Val Ala Arg Leu Glu Gly Val Lys Leu Leu Arg 
                245                 250                 255     


Ser Asn Lys Arg Leu Gly Ala Ile Arg Ala Arg Met Leu Gly Ala Thr 
            260                 265                 270         


Arg Ala Thr Gly Asp Val Leu Val Phe Met Asp Ala His Cys Glu Cys 
        275                 280                 285             


His Pro Gly Trp Leu Glu Pro Leu Leu Ser Arg Ile Ala Gly Asp Arg 
    290                 295                 300                 


Ser Arg Val Val Ser Pro Val Ile Asp Val Ile Asp Trp Lys Thr Phe 
305                 310                 315                 320 


Gln Tyr Tyr Pro Ser Lys Asp Leu Gln Arg Gly Val Leu Asp Trp Lys 
                325                 330                 335     


Leu Asp Phe His Trp Glu Pro Leu Pro Glu His Val Arg Lys Ala Leu 
            340                 345                 350         


Gln Ser Pro Ile Ser Pro Ile Arg Ser Pro Val Val Pro Gly Glu Val 
        355                 360                 365             


Val Ala Met Asp Arg His Tyr Phe Gln Asn Thr Gly Ala Tyr Asp Ser 
    370                 375                 380                 


Leu Met Ser Leu Arg Gly Gly Glu Asn Leu Glu Leu Ser Phe Lys Ala 
385                 390                 395                 400 


Trp Leu Cys Gly Gly Ser Val Glu Ile Leu Pro Cys Ser Arg Val Gly 
                405                 410                 415     


His Ile Tyr Gln Asn Gln Asp Ser His Ser Pro Leu Asp Gln Glu Ala 
            420                 425                 430         


Thr Leu Arg Asn Arg Val Arg Ile Ala Glu Thr Trp Leu Gly Ser Phe 
        435                 440                 445             


Lys Glu Thr Phe Tyr Lys His Ser Pro Glu Ala Phe Ser Leu Ser Lys 
    450                 455                 460                 


Ala Glu Lys Pro Asp Cys Met Glu Arg Leu Gln Leu Gln Arg Arg Leu 
465                 470                 475                 480 


Gly Cys Arg Thr Phe His Trp Phe Leu Ala Asn Val Tyr Pro Glu Leu 
                485                 490                 495     


Tyr Pro Ser Glu Pro Arg Pro Ser Phe Ser Gly Lys Leu His Asn Thr 
            500                 505                 510         


Gly Leu Gly Leu Cys Ala Asp Cys Gln Ala Glu Gly Asp Ile Leu Gly 
        515                 520                 525             


Cys Pro Met Val Leu Ala Pro Cys Ser Asp Ser Arg Gln Gln Gln Tyr 
    530                 535                 540                 


Leu Gln His Thr Ser Arg Lys Glu Ile His Phe Gly Ser Pro Gln His 
545                 550                 555                 560 


Leu Cys Phe Ala Val Arg Gln Glu Gln Val Ile Leu Gln Asn Cys Thr 
                565                 570                 575     


Glu Glu Gly Leu Ala Ile His Gln Gln His Trp Asp Phe Gln Glu Asp 
            580                 585                 590         


Glu Asn Arg Ala Asn Ser Ala Ala Ala Glu Ala Tyr Gln Arg Pro Leu 
        595                 600                 605             


Thr Phe Gln Gln Ile Val Asn Asn Gly 
    610                 615         


<210>  5762
<211>  571
<212>  PRT
<213>  Homo Sapiens

<400>  5762

Met Arg Arg Arg Ser Arg Met Leu Leu Cys Phe Ala Phe Leu Trp Val 
1               5                   10                  15      


Leu Gly Ile Ala Tyr Tyr Met Tyr Ser Gly Gly Gly Ser Ala Leu Ala 
            20                  25                  30          


Gly Gly Ala Gly Gly Gly Ala Gly Arg Lys Glu Asp Trp Asn Glu Ile 
        35                  40                  45              


Asp Pro Ile Lys Lys Lys Asp Leu His His Ser Asn Gly Glu Glu Lys 
    50                  55                  60                  


Ala Gln Ser Met Glu Thr Leu Pro Pro Gly Lys Val Arg Trp Pro Asp 
65                  70                  75                  80  


Phe Asn Gln Glu Ala Tyr Val Gly Gly Thr Met Val Arg Ser Gly Gln 
                85                  90                  95      


Asp Pro Tyr Ala Arg Asn Lys Phe Asn Gln Val Glu Ser Asp Lys Leu 
            100                 105                 110         


Arg Met Asp Arg Ala Ile Pro Asp Thr Arg His Asp Gln Cys Gln Arg 
        115                 120                 125             


Lys Gln Trp Arg Val Asp Leu Pro Ala Thr Ser Val Val Ile Thr Phe 
    130                 135                 140                 


His Asn Glu Ala Arg Ser Ala Leu Leu Arg Thr Val Val Ser Val Leu 
145                 150                 155                 160 


Lys Lys Ser Pro Pro His Leu Ile Lys Glu Ile Ile Leu Val Asp Asp 
                165                 170                 175     


Tyr Ser Asn Asp Pro Glu Asp Gly Ala Leu Leu Gly Lys Ile Glu Lys 
            180                 185                 190         


Val Arg Val Leu Arg Asn Asp Arg Arg Glu Gly Leu Met Arg Ser Arg 
        195                 200                 205             


Val Arg Gly Ala Asp Ala Ala Gln Ala Lys Val Leu Thr Phe Leu Asp 
    210                 215                 220                 


Ser His Cys Glu Cys Asn Glu His Trp Leu Glu Pro Leu Leu Glu Arg 
225                 230                 235                 240 


Val Ala Glu Asp Arg Thr Arg Val Val Ser Pro Ile Ile Asp Val Ile 
                245                 250                 255     


Asn Met Asp Asn Phe Gln Tyr Val Gly Ala Ser Ala Asp Leu Lys Gly 
            260                 265                 270         


Gly Phe Asp Trp Asn Leu Val Phe Lys Trp Asp Tyr Met Thr Pro Glu 
        275                 280                 285             


Gln Arg Arg Ser Arg Gln Gly Asn Pro Val Ala Pro Ile Lys Thr Pro 
    290                 295                 300                 


Met Ile Ala Gly Gly Leu Phe Val Met Asp Lys Phe Tyr Phe Glu Glu 
305                 310                 315                 320 


Leu Gly Lys Tyr Asp Met Met Met Asp Val Trp Gly Gly Glu Asn Leu 
                325                 330                 335     


Glu Ile Ser Phe Arg Val Trp Gln Cys Gly Gly Ser Leu Glu Ile Ile 
            340                 345                 350         


Pro Cys Ser Arg Val Gly His Val Phe Arg Lys Gln His Pro Tyr Thr 
        355                 360                 365             


Phe Pro Gly Gly Ser Gly Thr Val Phe Ala Arg Asn Thr Arg Arg Ala 
    370                 375                 380                 


Ala Glu Val Trp Met Asp Glu Tyr Lys Asn Phe Tyr Tyr Ala Ala Val 
385                 390                 395                 400 


Pro Ser Ala Arg Asn Val Pro Tyr Gly Asn Ile Gln Ser Arg Leu Glu 
                405                 410                 415     


Leu Arg Lys Lys Leu Ser Cys Lys Pro Phe Lys Trp Tyr Leu Glu Asn 
            420                 425                 430         


Val Tyr Pro Glu Leu Arg Val Pro Asp His Gln Asp Ile Ala Phe Gly 
        435                 440                 445             


Ala Leu Gln Gln Gly Thr Asn Cys Leu Asp Thr Leu Gly His Phe Ala 
    450                 455                 460                 


Asp Gly Val Val Gly Val Tyr Glu Cys His Asn Ala Gly Gly Asn Gln 
465                 470                 475                 480 


Glu Trp Ala Leu Thr Lys Glu Lys Ser Val Lys His Met Asp Leu Cys 
                485                 490                 495     


Leu Thr Val Val Asp Arg Ala Pro Gly Ser Leu Ile Lys Leu Gln Gly 
            500                 505                 510         


Cys Arg Glu Asn Asp Ser Arg Gln Lys Trp Glu Gln Ile Glu Gly Asn 
        515                 520                 525             


Ser Lys Leu Arg His Val Gly Ser Asn Leu Cys Leu Asp Ser Arg Thr 
    530                 535                 540                 


Ala Lys Ser Gly Gly Leu Ser Val Glu Val Cys Gly Pro Ala Leu Ser 
545                 550                 555                 560 


Gln Gln Trp Lys Phe Thr Leu Asn Leu Gln Gln 
                565                 570     


<210>  5763
<211>  23
<212>  PRT
<213>  Homo Sapiens

<400>  5763

Met Arg Leu Leu Arg Arg Arg His Met Pro Leu Arg Leu Ala Met Val 
1               5                   10                  15      


Gly Cys Ala Phe Val Leu Phe 
            20              


<210>  5764
<211>  23
<212>  PRT
<213>  Homo Sapiens

<400>  5764

Met Arg Leu Leu Arg Arg Arg His Met Pro Leu Arg Leu Ala Met Val 
1               5                   10                  15      


Gly Cys Ala Phe Val Leu Phe 
            20              


<210>  5765
<211>  39
<212>  PRT
<213>  Homo Sapiens

<400>  5765

Met Arg Leu Leu Arg Arg Arg His Met Pro Leu Arg Leu Ala Met Val 
1               5                   10                  15      


Gly Cys Ala Phe Val Leu Phe Leu Phe Leu Leu His Arg Asp Val Ser 
            20                  25                  30          


Ser Arg Glu Glu Ala Thr Glu 
        35                  


<210>  5766
<211>  55
<212>  PRT
<213>  Homo Sapiens

<400>  5766

Met Arg Leu Leu Arg Arg Arg His Met Pro Leu Arg Leu Ala Met Val 
1               5                   10                  15      


Gly Cys Ala Phe Val Leu Phe Leu Phe Leu Leu His Arg Asp Val Ser 
            20                  25                  30          


Ser Arg Glu Glu Ala Thr Glu Lys Pro Trp Leu Lys Ser Leu Val Ser 
        35                  40                  45              


Arg Lys Asp His Val Leu Asp 
    50                  55  


<210>  5767
<211>  62
<212>  PRT
<213>  Homo Sapiens

<400>  5767

Met Arg Leu Leu Arg Arg Arg His Met Pro Leu Arg Leu Ala Met Val 
1               5                   10                  15      


Gly Cys Ala Phe Val Leu Phe Leu Phe Leu Leu His Arg Asp Val Ser 
            20                  25                  30          


Ser Arg Glu Glu Ala Thr Glu Lys Pro Trp Leu Lys Ser Leu Val Ser 
        35                  40                  45              


Arg Lys Asp His Val Leu Asp Leu Met Leu Glu Ala Met Asn 
    50                  55                  60          


<210>  5768
<211>  69
<212>  PRT
<213>  Homo Sapiens

<400>  5768

Met Arg Leu Leu Arg Arg Arg His Met Pro Leu Arg Leu Ala Met Val 
1               5                   10                  15      


Gly Cys Ala Phe Val Leu Phe Leu Phe Leu Leu His Arg Asp Val Ser 
            20                  25                  30          


Ser Arg Glu Glu Ala Thr Glu Lys Pro Trp Leu Lys Ser Leu Val Ser 
        35                  40                  45              


Arg Lys Asp His Val Leu Asp Leu Met Leu Glu Ala Met Asn Asn Leu 
    50                  55                  60                  


Arg Asp Ser Met Pro 
65                  


<210>  5769
<211>  78
<212>  PRT
<213>  Homo Sapiens

<400>  5769

Met Arg Leu Leu Arg Arg Arg His Met Pro Leu Arg Leu Ala Met Val 
1               5                   10                  15      


Gly Cys Ala Phe Val Leu Phe Leu Phe Leu Leu His Arg Asp Val Ser 
            20                  25                  30          


Ser Arg Glu Glu Ala Thr Glu Lys Pro Trp Leu Lys Ser Leu Val Ser 
        35                  40                  45              


Arg Lys Asp His Val Leu Asp Leu Met Leu Glu Ala Met Asn Asn Leu 
    50                  55                  60                  


Arg Asp Ser Met Pro Lys Leu Gln Ile Arg Ala Pro Glu Ala 
65                  70                  75              


<210>  5770
<211>  123
<212>  PRT
<213>  Homo Sapiens

<400>  5770

Met Arg Leu Leu Arg Arg Arg His Met Pro Leu Arg Leu Ala Met Val 
1               5                   10                  15      


Gly Cys Ala Phe Val Leu Phe Leu Phe Leu Leu His Arg Asp Val Ser 
            20                  25                  30          


Ser Arg Glu Glu Ala Thr Glu Lys Pro Trp Leu Lys Ser Leu Val Ser 
        35                  40                  45              


Arg Lys Asp His Val Leu Asp Leu Met Leu Glu Ala Met Asn Asn Leu 
    50                  55                  60                  


Arg Asp Ser Met Pro Lys Leu Gln Ile Arg Ala Pro Glu Ala Gln Gln 
65                  70                  75                  80  


Thr Leu Phe Ser Ile Asn Gln Ser Cys Leu Pro Gly Phe Tyr Thr Pro 
                85                  90                  95      


Ala Glu Leu Lys Pro Phe Trp Glu Arg Pro Pro Gln Asp Pro Asn Ala 
            100                 105                 110         


Pro Gly Ala Asp Gly Lys Ala Phe Gln Lys Ser 
        115                 120             


<210>  5771
<211>  137
<212>  PRT
<213>  Homo Sapiens

<400>  5771

Met Arg Leu Leu Arg Arg Arg His Met Pro Leu Arg Leu Ala Met Val 
1               5                   10                  15      


Gly Cys Ala Phe Val Leu Phe Leu Phe Leu Leu His Arg Asp Val Ser 
            20                  25                  30          


Ser Arg Glu Glu Ala Thr Glu Lys Pro Trp Leu Lys Ser Leu Val Ser 
        35                  40                  45              


Arg Lys Asp His Val Leu Asp Leu Met Leu Glu Ala Met Asn Asn Leu 
    50                  55                  60                  


Arg Asp Ser Met Pro Lys Leu Gln Ile Arg Ala Pro Glu Ala Gln Gln 
65                  70                  75                  80  


Thr Leu Phe Ser Ile Asn Gln Ser Cys Leu Pro Gly Phe Tyr Thr Pro 
                85                  90                  95      


Ala Glu Leu Lys Pro Phe Trp Glu Arg Pro Pro Gln Asp Pro Asn Ala 
            100                 105                 110         


Pro Gly Ala Asp Gly Lys Ala Phe Gln Lys Ser Lys Trp Thr Pro Leu 
        115                 120                 125             


Glu Thr Gln Glu Lys Glu Glu Gly Tyr 
    130                 135         


<210>  5772
<211>  622
<212>  PRT
<213>  Homo Sapiens

<400>  5772

Met Arg Leu Leu Arg Arg Arg His Met Pro Leu Arg Leu Ala Met Val 
1               5                   10                  15      


Gly Cys Ala Phe Val Leu Phe Leu Phe Leu Leu His Arg Asp Val Ser 
            20                  25                  30          


Ser Arg Glu Glu Ala Thr Glu Lys Pro Trp Leu Lys Ser Leu Val Ser 
        35                  40                  45              


Arg Lys Asp His Val Leu Asp Leu Met Leu Glu Ala Met Asn Asn Leu 
    50                  55                  60                  


Arg Asp Ser Met Pro Lys Leu Gln Ile Arg Ala Pro Glu Ala Gln Gln 
65                  70                  75                  80  


Thr Leu Phe Ser Ile Asn Gln Ser Cys Leu Pro Gly Phe Tyr Thr Pro 
                85                  90                  95      


Ala Glu Leu Lys Pro Phe Trp Glu Arg Pro Pro Gln Asp Pro Asn Ala 
            100                 105                 110         


Pro Gly Ala Asp Gly Lys Ala Phe Gln Lys Ser Lys Trp Thr Pro Leu 
        115                 120                 125             


Glu Thr Gln Glu Lys Glu Glu Gly Tyr Lys Lys His Cys Phe Asn Ala 
    130                 135                 140                 


Phe Ala Ser Asp Arg Ile Ser Leu Gln Arg Ser Leu Gly Pro Asp Thr 
145                 150                 155                 160 


Arg Pro Pro Glu Cys Val Asp Gln Lys Phe Arg Arg Cys Pro Pro Leu 
                165                 170                 175     


Ala Thr Thr Ser Val Ile Ile Val Phe His Asn Glu Ala Trp Ser Thr 
            180                 185                 190         


Leu Leu Arg Thr Val Tyr Ser Val Leu His Thr Thr Pro Ala Ile Leu 
        195                 200                 205             


Leu Lys Glu Ile Ile Leu Val Asp Asp Ala Ser Thr Glu Glu His Leu 
    210                 215                 220                 


Lys Glu Lys Leu Glu Gln Tyr Val Lys Gln Leu Gln Val Val Arg Val 
225                 230                 235                 240 


Val Arg Gln Glu Glu Arg Lys Gly Leu Ile Thr Ala Arg Leu Leu Gly 
                245                 250                 255     


Ala Ser Val Ala Gln Ala Glu Val Leu Thr Phe Leu Asp Ala His Cys 
            260                 265                 270         


Glu Cys Phe His Gly Trp Leu Glu Pro Leu Leu Ala Arg Ile Ala Glu 
        275                 280                 285             


Asp Lys Thr Val Val Val Ser Pro Asp Ile Val Thr Ile Asp Leu Asn 
    290                 295                 300                 


Thr Phe Glu Phe Ala Lys Pro Val Gln Arg Gly Arg Val His Ser Arg 
305                 310                 315                 320 


Gly Asn Phe Asp Trp Ser Leu Thr Phe Gly Trp Glu Thr Leu Pro Pro 
                325                 330                 335     


His Glu Lys Gln Arg Arg Lys Asp Glu Thr Tyr Pro Ile Lys Ser Pro 
            340                 345                 350         


Thr Phe Ala Gly Gly Leu Phe Ser Ile Ser Lys Ser Tyr Phe Glu His 
        355                 360                 365             


Ile Gly Thr Tyr Asp Asn Gln Met Glu Ile Trp Gly Gly Glu Asn Val 
    370                 375                 380                 


Glu Met Ser Phe Arg Val Trp Gln Cys Gly Gly Gln Leu Glu Ile Ile 
385                 390                 395                 400 


Pro Cys Ser Val Val Gly His Val Phe Arg Thr Lys Ser Pro His Thr 
                405                 410                 415     


Phe Pro Lys Gly Thr Ser Val Ile Ala Arg Asn Gln Val Arg Leu Ala 
            420                 425                 430         


Glu Val Trp Met Asp Ser Tyr Lys Lys Ile Phe Tyr Arg Arg Asn Leu 
        435                 440                 445             


Gln Ala Ala Lys Met Ala Gln Glu Lys Ser Phe Gly Asp Ile Ser Glu 
    450                 455                 460                 


Arg Leu Gln Leu Arg Glu Gln Leu His Cys His Asn Phe Ser Trp Tyr 
465                 470                 475                 480 


Leu His Asn Val Tyr Pro Glu Met Phe Val Pro Asp Leu Thr Pro Thr 
                485                 490                 495     


Phe Tyr Gly Ala Ile Lys Asn Leu Gly Thr Asn Gln Cys Leu Asp Val 
            500                 505                 510         


Gly Glu Asn Asn Arg Gly Gly Lys Pro Leu Ile Met Tyr Ser Cys His 
        515                 520                 525             


Gly Leu Gly Gly Asn Gln Tyr Phe Glu Tyr Thr Thr Gln Arg Asp Leu 
    530                 535                 540                 


Arg His Asn Ile Ala Lys Gln Leu Cys Leu His Val Ser Lys Gly Ala 
545                 550                 555                 560 


Leu Gly Leu Gly Ser Cys His Phe Thr Gly Lys Asn Ser Gln Val Pro 
                565                 570                 575     


Lys Asp Glu Glu Trp Glu Leu Ala Gln Asp Gln Leu Ile Arg Asn Ser 
            580                 585                 590         


Gly Ser Gly Thr Cys Leu Thr Ser Gln Asp Lys Lys Pro Ala Met Ala 
        595                 600                 605             


Pro Cys Asn Pro Ser Asp Pro His Gln Leu Trp Leu Phe Val 
    610                 615                 620         


<210>  5773
<211>  365
<212>  PRT
<213>  Homo Sapiens

<400>  5773

Met Arg Leu Leu Arg Arg Arg His Met Pro Leu Arg Leu Ala Met Val 
1               5                   10                  15      


Gly Cys Ala Phe Val Leu Phe Leu Phe Leu Leu His Arg Asp Val Ser 
            20                  25                  30          


Ser Arg Glu Glu Ala Thr Glu Lys Pro Trp Leu Lys Ser Leu Val Ser 
        35                  40                  45              


Arg Lys Asp His Val Leu Asp Leu Met Leu Glu Ala Met Asn Asn Leu 
    50                  55                  60                  


Arg Asp Ser Met Pro Lys Leu Gln Ile Arg Ala Pro Glu Ala Gln Gln 
65                  70                  75                  80  


Thr Leu Phe Ser Ile Asn Gln Ser Cys Leu Pro Gly Phe Tyr Thr Pro 
                85                  90                  95      


Ala Glu Leu Lys Pro Phe Trp Glu Arg Pro Pro Gln Asp Pro Asn Ala 
            100                 105                 110         


Pro Gly Ala Asp Gly Lys Ala Phe Gln Lys Ser Lys Trp Thr Pro Leu 
        115                 120                 125             


Glu Thr Gln Glu Lys Glu Glu Gly Tyr Lys Lys His Cys Phe Asn Ala 
    130                 135                 140                 


Phe Ala Ser Asp Arg Ile Ser Leu Gln Arg Ser Leu Gly Pro Asp Thr 
145                 150                 155                 160 


Arg Pro Pro Glu Cys Val Asp Gln Lys Phe Arg Arg Cys Pro Pro Leu 
                165                 170                 175     


Ala Thr Thr Ser Val Ile Ile Val Phe His Asn Glu Ala Trp Ser Thr 
            180                 185                 190         


Leu Leu Arg Thr Val Tyr Ser Val Leu His Thr Thr Pro Ala Ile Leu 
        195                 200                 205             


Leu Lys Glu Ile Ile Leu Val Asp Asp Ala Ser Thr Glu Glu His Leu 
    210                 215                 220                 


Lys Glu Lys Leu Glu Gln Tyr Val Lys Gln Leu Gln Val Val Arg Val 
225                 230                 235                 240 


Val Arg Gln Glu Glu Arg Lys Gly Leu Ile Thr Ala Arg Leu Leu Gly 
                245                 250                 255     


Ala Ser Val Ala Gln Ala Glu Val Leu Thr Phe Leu Asp Ala His Cys 
            260                 265                 270         


Glu Cys Phe His Gly Trp Leu Glu Pro Leu Leu Ala Arg Ile Ala Glu 
        275                 280                 285             


Asp Lys Thr Val Val Val Ser Pro Asp Ile Val Thr Ile Asp Leu Asn 
    290                 295                 300                 


Thr Phe Glu Phe Ala Lys Pro Val Gln Arg Gly Arg Val His Ser Arg 
305                 310                 315                 320 


Gly Asn Phe Asp Trp Ser Leu Thr Phe Gly Trp Glu Thr Leu Pro Pro 
                325                 330                 335     


His Glu Lys Gln Arg Arg Lys Asp Glu Thr Tyr Pro Ile Lys Cys Gly 
            340                 345                 350         


Ser Val Gly Ala Ser Trp Arg Ser Ser Pro Ala Leu Ser 
        355                 360                 365 


<210>  5774
<211>  622
<212>  PRT
<213>  Homo Sapiens

<400>  5774

Met Arg Leu Leu Arg Arg Arg His Met Pro Leu Arg Leu Ala Met Val 
1               5                   10                  15      


Gly Cys Ala Phe Val Leu Phe Leu Phe Leu Leu His Arg Asp Val Ser 
            20                  25                  30          


Ser Arg Glu Glu Ala Thr Glu Lys Pro Trp Leu Lys Ser Leu Val Ser 
        35                  40                  45              


Arg Lys Asp His Val Leu Asp Leu Met Leu Glu Ala Met Asn Asn Leu 
    50                  55                  60                  


Arg Asp Ser Met Pro Lys Leu Gln Ile Arg Ala Pro Glu Ala Gln Gln 
65                  70                  75                  80  


Thr Leu Phe Ser Ile Asn Gln Ser Cys Leu Pro Gly Phe Tyr Thr Pro 
                85                  90                  95      


Ala Glu Leu Lys Pro Phe Trp Glu Arg Pro Pro Gln Asp Pro Asn Ala 
            100                 105                 110         


Pro Gly Ala Asp Gly Lys Ala Phe Gln Lys Ser Lys Trp Thr Pro Leu 
        115                 120                 125             


Glu Thr Gln Glu Lys Glu Glu Gly Tyr Lys Lys His Cys Phe Asn Ala 
    130                 135                 140                 


Phe Ala Ser Asp Arg Ile Ser Leu Gln Arg Ser Leu Gly Pro Asp Thr 
145                 150                 155                 160 


Arg Pro Pro Glu Cys Val Asp Gln Lys Phe Arg Arg Cys Pro Pro Leu 
                165                 170                 175     


Ala Thr Thr Ser Val Ile Ile Val Phe His Asn Glu Ala Trp Ser Thr 
            180                 185                 190         


Leu Leu Arg Thr Val Tyr Ser Val Leu His Thr Thr Pro Ala Ile Leu 
        195                 200                 205             


Leu Lys Glu Ile Ile Leu Val Asp Asp Ala Ser Thr Glu Glu His Leu 
    210                 215                 220                 


Lys Glu Lys Leu Glu Gln Tyr Val Lys Gln Leu Gln Val Val Arg Val 
225                 230                 235                 240 


Val Arg Gln Glu Glu Arg Lys Gly Leu Ile Thr Ala Arg Leu Leu Gly 
                245                 250                 255     


Ala Ser Val Ala Gln Ala Glu Val Leu Thr Phe Leu Asp Ala His Cys 
            260                 265                 270         


Glu Cys Phe His Gly Trp Leu Glu Pro Leu Leu Ala Arg Ile Ala Glu 
        275                 280                 285             


Asp Lys Thr Val Val Val Ser Pro Asp Ile Val Thr Ile Asp Leu Asn 
    290                 295                 300                 


Thr Phe Glu Phe Ala Lys Pro Val Gln Arg Gly Arg Val His Ser Arg 
305                 310                 315                 320 


Gly Asn Phe Asp Trp Ser Leu Thr Phe Gly Trp Glu Thr Leu Pro Pro 
                325                 330                 335     


His Glu Lys Gln Arg Arg Lys Asp Glu Thr Tyr Pro Ile Lys Ser Pro 
            340                 345                 350         


Thr Phe Ala Gly Gly Leu Phe Ser Ile Ser Lys Ser Tyr Phe Glu His 
        355                 360                 365             


Ile Gly Thr Tyr Asp Asn Gln Met Glu Ile Trp Gly Gly Glu Asn Val 
    370                 375                 380                 


Glu Met Ser Phe Arg Val Trp Gln Cys Gly Gly Gln Leu Glu Ile Ile 
385                 390                 395                 400 


Pro Cys Ser Val Val Gly His Val Phe Arg Thr Lys Ser Pro His Thr 
                405                 410                 415     


Phe Pro Lys Gly Thr Ser Val Ile Ala Arg Asn Gln Val Arg Leu Ala 
            420                 425                 430         


Glu Val Trp Met Asp Ser Tyr Lys Lys Ile Phe Tyr Arg Arg Asn Leu 
        435                 440                 445             


Gln Ala Ala Lys Met Ala Gln Glu Lys Ser Phe Gly Asp Ile Ser Glu 
    450                 455                 460                 


Arg Leu Gln Leu Arg Glu Gln Leu His Cys His Asn Phe Ser Trp Tyr 
465                 470                 475                 480 


Leu His Asn Val Tyr Pro Glu Met Phe Val Pro Asp Leu Thr Pro Thr 
                485                 490                 495     


Phe Tyr Gly Ala Ile Lys Asn Leu Gly Thr Asn Gln Cys Leu Asp Val 
            500                 505                 510         


Gly Glu Asn Asn Arg Gly Gly Lys Pro Leu Ile Met Tyr Ser Cys His 
        515                 520                 525             


Gly Leu Gly Gly Asn Gln Tyr Phe Glu Tyr Thr Thr Gln Arg Asp Leu 
    530                 535                 540                 


Arg His Asn Ile Ala Lys Gln Leu Cys Leu His Val Ser Lys Gly Ala 
545                 550                 555                 560 


Leu Gly Leu Gly Ser Cys His Phe Thr Gly Lys Asn Ser Gln Val Pro 
                565                 570                 575     


Lys Asp Glu Glu Trp Glu Leu Ala Gln Asp Gln Leu Ile Arg Asn Ser 
            580                 585                 590         


Gly Ser Gly Thr Cys Leu Thr Ser Gln Asp Lys Lys Pro Ala Met Ala 
        595                 600                 605             


Pro Cys Asn Pro Ser Asp Pro His Gln Leu Trp Leu Phe Val 
    610                 615                 620         


<210>  5775
<211>  637
<212>  PRT
<213>  Homo Sapiens

<400>  5775

Met Met Phe Trp Arg Lys Leu Pro Lys Ala Leu Phe Ile Gly Leu Thr 
1               5                   10                  15      


Leu Ala Ile Ala Val Asn Leu Leu Leu Val Phe Ser Ser Lys Gly Thr 
            20                  25                  30          


Leu Gln Asn Leu Phe Thr Gly Gly Leu His Arg Glu Leu Pro Leu His 
        35                  40                  45              


Leu Asn Lys Arg Tyr Gly Ala Val Ile Lys Arg Leu Ser His Leu Glu 
    50                  55                  60                  


Val Glu Leu Gln Asp Leu Lys Glu Ser Met Lys Leu Ala Leu Arg Gln 
65                  70                  75                  80  


Gln Glu Asn Val Asn Ser Thr Leu Lys Arg Ala Lys Asp Glu Val Arg 
                85                  90                  95      


Pro Leu Leu Lys Ala Met Glu Thr Lys Val Asn Glu Thr Lys Lys His 
            100                 105                 110         


Lys Thr Gln Met Lys Leu Phe Pro His Ser Gln Leu Phe Arg Gln Trp 
        115                 120                 125             


Gly Glu Asp Leu Ser Glu Ala Gln Gln Lys Ala Ala Gln Asp Leu Phe 
    130                 135                 140                 


Arg Lys Phe Gly Tyr Asn Ala Tyr Leu Ser Asn Gln Leu Pro Leu Asn 
145                 150                 155                 160 


Arg Thr Ile Pro Asp Thr Arg Asp Tyr Arg Cys Leu Arg Lys Thr Tyr 
                165                 170                 175     


Pro Ser Gln Leu Pro Ser Leu Ser Val Ile Leu Ile Phe Val Asn Glu 
            180                 185                 190         


Ala Leu Ser Ile Ile Gln Arg Ala Ile Thr Ser Ile Ile Asn Arg Thr 
        195                 200                 205             


Pro Ser Arg Leu Leu Lys Glu Ile Ile Leu Val Asp Asp Phe Ser Ser 
    210                 215                 220                 


Asn Gly Glu Leu Lys Val His Leu Asp Glu Lys Ile Lys Leu Tyr Asn 
225                 230                 235                 240 


Gln Lys Tyr Pro Gly Leu Leu Lys Ile Ile Arg His Pro Glu Arg Lys 
                245                 250                 255     


Gly Leu Ala Gln Ala Arg Asn Thr Gly Trp Glu Ala Ala Thr Ala Asp 
            260                 265                 270         


Val Val Ala Ile Leu Asp Ala His Ile Glu Val Asn Val Gly Trp Ala 
        275                 280                 285             


Glu Pro Ile Leu Ala Arg Ile Gln Glu Asp Arg Thr Val Ile Val Ser 
    290                 295                 300                 


Pro Val Phe Asp Asn Ile Arg Phe Asp Thr Phe Lys Leu Asp Lys Tyr 
305                 310                 315                 320 


Glu Leu Ala Val Asp Gly Phe Asn Trp Glu Leu Trp Cys Arg Tyr Asp 
                325                 330                 335     


Ala Leu Pro Gln Ala Trp Ile Asp Leu His Asp Val Thr Ala Pro Val 
            340                 345                 350         


Lys Ser Pro Ser Ile Met Gly Ile Leu Ala Ala Asn Arg His Phe Leu 
        355                 360                 365             


Gly Glu Ile Gly Ser Leu Asp Gly Gly Met Leu Ile Tyr Gly Gly Glu 
    370                 375                 380                 


Asn Val Glu Leu Ser Leu Arg Val Trp Gln Cys Gly Gly Lys Val Glu 
385                 390                 395                 400 


Ile Leu Pro Cys Ser Arg Ile Ala His Leu Glu Arg His His Lys Pro 
                405                 410                 415     


Tyr Ala Leu Asp Leu Thr Ala Ala Leu Lys Arg Asn Ala Leu Arg Val 
            420                 425                 430         


Ala Glu Ile Trp Met Asp Glu His Lys His Met Val Tyr Leu Ala Trp 
        435                 440                 445             


Asn Ile Pro Leu Gln Asn Ser Gly Ile Asp Phe Gly Asp Val Ser Ser 
    450                 455                 460                 


Arg Met Ala Leu Arg Glu Lys Leu Lys Cys Lys Thr Phe Asp Trp Tyr 
465                 470                 475                 480 


Leu Lys Asn Val Tyr Pro Leu Leu Lys Pro Leu His Thr Ile Val Gly 
                485                 490                 495     


Tyr Gly Arg Met Lys Asn Leu Leu Asp Glu Asn Val Cys Leu Asp Gln 
            500                 505                 510         


Gly Pro Val Pro Gly Asn Thr Pro Ile Met Tyr Tyr Cys His Glu Phe 
        515                 520                 525             


Ser Ser Gln Asn Val Tyr Tyr His Leu Thr Gly Glu Leu Tyr Val Gly 
    530                 535                 540                 


Gln Leu Ile Ala Glu Ala Ser Ala Ser Asp Arg Cys Leu Thr Asp Pro 
545                 550                 555                 560 


Gly Lys Ala Glu Lys Pro Thr Leu Glu Pro Cys Ser Lys Ala Ala Lys 
                565                 570                 575     


Asn Arg Leu His Ile Tyr Trp Asp Phe Lys Pro Gly Gly Ala Val Ile 
            580                 585                 590         


Asn Arg Asp Thr Lys Arg Cys Leu Glu Met Lys Lys Asp Leu Leu Gly 
        595                 600                 605             


Ser His Val Leu Val Leu Gln Thr Cys Ser Thr Gln Val Trp Glu Ile 
    610                 615                 620                 


Gln His Thr Val Arg Asp Trp Gly Gln Thr Asn Ser Gln 
625                 630                 635         


<210>  5776
<211>  529
<212>  PRT
<213>  Homo Sapiens

<400>  5776

Met Arg Ser Glu Lys Ser Leu Thr Leu Ala Ala Pro Gly Glu Val Arg 
1               5                   10                  15      


Gly Pro Glu Gly Glu Gln Gln Asp Ala Gly Asp Phe Pro Glu Ala Gly 
            20                  25                  30          


Gly Gly Gly Gly Cys Cys Ser Ser Glu Arg Leu Val Ile Asn Ile Ser 
        35                  40                  45              


Gly Leu Arg Phe Glu Thr Gln Leu Arg Thr Leu Ser Leu Phe Pro Asp 
    50                  55                  60                  


Thr Leu Leu Gly Asp Pro Gly Arg Arg Val Arg Phe Phe Asp Pro Leu 
65                  70                  75                  80  


Arg Asn Glu Tyr Phe Phe Asp Arg Asn Arg Pro Ser Phe Asp Ala Ile 
                85                  90                  95      


Leu Tyr Tyr Tyr Gln Ser Gly Gly Arg Leu Arg Arg Pro Val Asn Val 
            100                 105                 110         


Pro Leu Asp Ile Phe Leu Glu Glu Ile Arg Phe Tyr Gln Leu Gly Asp 
        115                 120                 125             


Glu Ala Leu Ala Ala Phe Arg Glu Asp Glu Gly Cys Leu Pro Glu Gly 
    130                 135                 140                 


Gly Glu Asp Glu Lys Pro Leu Pro Ser Gln Pro Phe Gln Arg Gln Val 
145                 150                 155                 160 


Trp Leu Leu Phe Glu Tyr Pro Glu Ser Ser Gly Pro Ala Arg Gly Ile 
                165                 170                 175     


Ala Ile Val Ser Val Leu Val Ile Leu Ile Ser Ile Val Ile Phe Cys 
            180                 185                 190         


Leu Glu Thr Leu Pro Gln Phe Arg Val Asp Gly Arg Gly Gly Asn Asn 
        195                 200                 205             


Gly Gly Val Ser Arg Val Ser Pro Val Ser Arg Gly Ser Gln Glu Glu 
    210                 215                 220                 


Glu Glu Asp Glu Asp Asp Ser Tyr Thr Phe His His Gly Ile Thr Pro 
225                 230                 235                 240 


Gly Glu Met Gly Thr Gly Gly Ser Ser Ser Leu Ser Thr Leu Gly Gly 
                245                 250                 255     


Ser Phe Phe Thr Asp Pro Phe Phe Leu Val Glu Thr Leu Cys Ile Val 
            260                 265                 270         


Trp Phe Thr Phe Glu Leu Leu Val Arg Phe Ser Ala Cys Pro Ser Lys 
        275                 280                 285             


Pro Ala Phe Phe Arg Asn Ile Met Asn Ile Ile Asp Leu Val Ala Ile 
    290                 295                 300                 


Phe Pro Tyr Phe Ile Thr Leu Gly Thr Glu Leu Val Gln Gln Gln Glu 
305                 310                 315                 320 


Gln Gln Pro Ala Ser Gly Gly Gly Gly Gln Asn Gly Gln Gln Ala Met 
                325                 330                 335     


Ser Leu Ala Ile Leu Arg Val Ile Arg Leu Val Arg Val Phe Arg Ile 
            340                 345                 350         


Phe Lys Leu Ser Arg His Ser Lys Gly Leu Gln Ile Leu Gly Lys Thr 
        355                 360                 365             


Leu Gln Ala Ser Met Arg Glu Leu Gly Leu Leu Ile Phe Phe Leu Phe 
    370                 375                 380                 


Ile Gly Val Ile Leu Phe Ser Ser Ala Val Tyr Phe Ala Glu Ala Asp 
385                 390                 395                 400 


Asp Asp Asp Ser Leu Phe Pro Ser Ile Pro Asp Ala Phe Trp Trp Ala 
                405                 410                 415     


Val Val Thr Met Thr Thr Val Gly Tyr Gly Asp Met Tyr Pro Met Thr 
            420                 425                 430         


Val Gly Gly Lys Ile Val Gly Ser Leu Cys Ala Ile Ala Gly Val Leu 
        435                 440                 445             


Thr Ile Ala Leu Pro Val Pro Val Ile Val Ser Asn Phe Asn Tyr Phe 
    450                 455                 460                 


Tyr His Arg Glu Thr Glu Gln Glu Glu Gln Gly Gln Tyr Thr His Val 
465                 470                 475                 480 


Thr Cys Gly Gln Pro Ala Pro Asp Leu Arg Ala Thr Asp Asn Gly Leu 
                485                 490                 495     


Gly Lys Pro Asp Phe Pro Glu Ala Asn Arg Glu Arg Arg Pro Ser Tyr 
            500                 505                 510         


Leu Pro Thr Pro His Arg Ala Tyr Ala Glu Lys Arg Met Leu Thr Glu 
        515                 520                 525             


Val 
    


<210>  5777
<211>  88
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5777

Xaa Glu Asn Val Cys Leu Asp Gln Gly Pro Val Pro Gly Asn Thr Pro 
1               5                   10                  15      


Ile Met Tyr Tyr Cys His Glu Phe Ser Ser Gln Asn Val Tyr Tyr His 
            20                  25                  30          


Leu Thr Gly Glu Leu Tyr Val Gly Gln Leu Ile Ala Glu Ala Ser Ala 
        35                  40                  45              


Ser Asp Arg Cys Leu Thr Asp Pro Gly Lys Ala Glu Lys Pro Thr Leu 
    50                  55                  60                  


Glu Pro Cys Ser Lys Ala Ala Lys Asn Arg Leu His Ile Tyr Trp Asp 
65                  70                  75                  80  


Phe Lys Pro Pro Thr Ile Thr Lys 
                85              


<210>  5778
<211>  161
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5778

Xaa Tyr Pro Leu Leu Lys Pro Leu His Thr Ile Val Gly Tyr Gly Arg 
1               5                   10                  15      


Met Lys Asn Leu Leu Asp Glu Asn Val Cys Leu Asp Gln Gly Pro Val 
            20                  25                  30          


Pro Gly Asn Thr Pro Ile Met Tyr Tyr Cys His Glu Phe Ser Ser Gln 
        35                  40                  45              


Asn Val Tyr Tyr His Leu Thr Gly Glu Leu Tyr Val Gly Gln Leu Ile 
    50                  55                  60                  


Ala Glu Ala Ser Ala Ser Asp Arg Cys Leu Thr Asp Pro Gly Lys Ala 
65                  70                  75                  80  


Glu Lys Pro Thr Leu Glu Pro Cys Ser Lys Ala Ala Lys Asn Arg Leu 
                85                  90                  95      


His Ile Tyr Trp Asp Phe Lys Pro Glu Lys Cys Trp Gln Val Val Gln 
            100                 105                 110         


Ala Arg Thr Ser Met His Arg Ile Leu Thr Ala Ala Gly Pro Ser Thr 
        115                 120                 125             


Ser Ser Glu Asp Glu Asn Pro Ala Trp His Arg Trp Gln Ala Ser Gly 
    130                 135                 140                 


Leu Thr Pro Leu Trp Arg Pro Pro Thr Ser Ser Asn Gln Ala Arg Lys 
145                 150                 155                 160 


Ser 
    


<210>  5779
<211>  417
<212>  PRT
<213>  Homo Sapiens

<400>  5779

Glu His Leu Lys Asp Lys Leu Glu Glu Tyr Met Ala Arg Phe Ser Lys 
1               5                   10                  15      


Val Arg Ile Val Arg Thr Lys Lys Arg Glu Gly Leu Ile Arg Thr Arg 
            20                  25                  30          


Leu Leu Gly Ala Ser Met Ala Arg Gly Glu Val Leu Thr Phe Leu Asp 
        35                  40                  45              


Ser His Cys Glu Val Asn Val Asn Trp Leu Pro Pro Leu Leu Asn Gln 
    50                  55                  60                  


Ile Ala Leu Asn His Lys Thr Ile Val Cys Pro Met Ile Asp Val Ile 
65                  70                  75                  80  


Asp His Asn His Phe Gly Tyr Glu Ala Gln Ala Gly Asp Ala Met Arg 
                85                  90                  95      


Gly Ala Phe Asp Trp Glu Met Tyr Tyr Lys Arg Ile Pro Ile Pro Pro 
            100                 105                 110         


Glu Leu Gln Arg Ala Asp Pro Ser Asp Pro Phe Glu Ser Pro Val Met 
        115                 120                 125             


Ala Gly Gly Leu Phe Ala Val Asp Arg Lys Trp Phe Trp Glu Leu Gly 
    130                 135                 140                 


Gly Tyr Asp Pro Gly Leu Glu Ile Trp Gly Gly Glu Gln Tyr Glu Ile 
145                 150                 155                 160 


Ser Phe Lys Val Trp Met Cys Gly Gly Glu Met Phe Asp Val Pro Cys 
                165                 170                 175     


Ser Arg Val Gly His Ile Tyr Arg Lys Tyr Val Pro Tyr Lys Val Pro 
            180                 185                 190         


Ser Gly Thr Ser Leu Ala Arg Asn Leu Lys Arg Val Ala Glu Thr Trp 
        195                 200                 205             


Met Asp Glu Phe Ala Glu Tyr Ile Tyr Gln Arg Arg Pro Glu Tyr Arg 
    210                 215                 220                 


His Leu Ser Thr Gly Asp Ile Ser Ala Gln Lys Glu Leu Arg Lys Gln 
225                 230                 235                 240 


Leu Lys Cys Lys Asp Phe Lys Trp Phe Met Ala Ala Val Ala Trp Asp 
                245                 250                 255     


Val Pro Lys Tyr Tyr Pro Pro Val Glu Pro Pro Pro Ala Ala Trp Gly 
            260                 265                 270         


Glu Ile Arg Asn Val Ala Ala Asn Leu Cys Val Asp Ser Lys His Gly 
        275                 280                 285             


Ala Thr Gly Thr Glu Leu Arg Leu Asp Ile Cys Val Lys Asp Gly Ser 
    290                 295                 300                 


Glu Arg Thr Trp Ser His Glu Gln Leu Phe Thr Phe Gly Trp Arg Glu 
305                 310                 315                 320 


Asp Ile Arg Pro Gly Glu Pro Leu His Thr Arg Lys Phe Cys Phe Asp 
                325                 330                 335     


Ala Ile Ser His Asn Ser Pro Val Thr Leu Tyr Asp Cys His Gly Met 
            340                 345                 350         


Lys Gly Asn Gln Leu Trp Gly Tyr Arg Lys Asp Arg Thr Leu Phe His 
        355                 360                 365             


Pro Val Ser Asn Ser Cys Met Asp Cys Asn Pro Ala Glu Lys Lys Ile 
    370                 375                 380                 


Phe Met Ala Arg Cys Asp Pro Leu Ser Glu Thr Gln Gln Trp Ile Phe 
385                 390                 395                 400 


Glu His Ile Asn Met Thr Val Leu Glu Lys Phe Asn His His Ala Asn 
                405                 410                 415     


Ser 
    


<210>  5780
<211>  601
<212>  PRT
<213>  Homo Sapiens

<400>  5780

Met Lys Arg Lys Gln Lys Arg Phe Leu Gln Met Thr Leu Leu Phe Thr 
1               5                   10                  15      


Val Ala Leu Ile Phe Leu Pro Asn Val Gly Leu Trp Ser Leu Tyr Lys 
            20                  25                  30          


Asp Lys His Leu Val Lys Ser Ala Glu Pro Gly Glu Gln Gln Thr Phe 
        35                  40                  45              


Pro Leu Gly Leu Gly Asp Gly Gln Phe Tyr Ser Trp Thr Asp Gly Leu 
    50                  55                  60                  


Arg Arg Lys Asp Trp His Asp Tyr Glu Ser Ile Gln Lys Glu Ala Met 
65                  70                  75                  80  


Arg Ser Gly Lys Gly Glu His Gly Lys Pro Tyr Pro Leu Thr Glu Glu 
                85                  90                  95      


Asp His Asp Asp Ser Ala Tyr Arg Glu Asn Gly Phe Asn Ile Phe Val 
            100                 105                 110         


Ser Asn Asn Ile Ala Leu Glu Arg Ser Leu Pro Asp Ile Arg His Ala 
        115                 120                 125             


Asn Cys Lys His Lys Met Tyr Leu Glu Arg Leu Pro Asn Thr Ser Ile 
    130                 135                 140                 


Ile Ile Pro Phe His Asn Glu Gly Trp Thr Ser Leu Leu Arg Thr Ile 
145                 150                 155                 160 


His Ser Ile Ile Asn Arg Thr Pro Gly Ser Leu Ile Ala Glu Ile Ile 
                165                 170                 175     


Leu Val Asp Asp Phe Ser Glu Arg Glu His Leu Lys Asp Lys Leu Glu 
            180                 185                 190         


Glu Tyr Met Ala Arg Phe Ser Lys Val Arg Ile Val Arg Thr Lys Lys 
        195                 200                 205             


Arg Glu Gly Leu Ile Arg Thr Arg Leu Leu Gly Ala Ser Met Ala Arg 
    210                 215                 220                 


Gly Glu Val Leu Thr Phe Leu Asp Ser His Cys Glu Val Asn Val Asn 
225                 230                 235                 240 


Trp Leu Pro Pro Leu Leu Asn Gln Ile Ala Leu Asn His Lys Thr Ile 
                245                 250                 255     


Val Cys Pro Met Ile Asp Val Ile Asp His Asn His Phe Gly Tyr Glu 
            260                 265                 270         


Ala Gln Ala Gly Asp Ala Met Arg Gly Ala Phe Asp Trp Glu Met Tyr 
        275                 280                 285             


Tyr Lys Arg Ile Pro Ile Pro Pro Glu Leu Gln Arg Ala Asp Pro Ser 
    290                 295                 300                 


Asp Pro Phe Glu Ser Pro Val Met Ala Gly Gly Leu Phe Ala Val Asp 
305                 310                 315                 320 


Arg Lys Trp Phe Trp Glu Leu Gly Gly Tyr Asp Pro Gly Leu Glu Ile 
                325                 330                 335     


Trp Gly Gly Glu Gln Tyr Glu Ile Ser Phe Lys Val Trp Met Cys Gly 
            340                 345                 350         


Gly Glu Met Phe Asp Val Pro Cys Ser Arg Val Gly His Ile Tyr Arg 
        355                 360                 365             


Lys Tyr Val Pro Tyr Lys Val Pro Ser Gly Thr Ser Leu Ala Arg Asn 
    370                 375                 380                 


Leu Lys Arg Val Ala Glu Thr Trp Met Asp Glu Phe Ala Glu Tyr Ile 
385                 390                 395                 400 


Tyr Gln Arg Arg Pro Glu Tyr Arg His Leu Ser Thr Gly Asp Ile Ser 
                405                 410                 415     


Ala Gln Lys Glu Leu Arg Lys Gln Leu Lys Cys Lys Asp Phe Lys Trp 
            420                 425                 430         


Phe Met Ala Ala Val Ala Trp Asp Val Pro Lys Tyr Tyr Pro Pro Val 
        435                 440                 445             


Glu Pro Pro Pro Ala Ala Trp Gly Glu Ile Arg Asn Val Ala Ala Asn 
    450                 455                 460                 


Leu Cys Val Asp Ser Lys His Gly Ala Thr Gly Thr Glu Leu Arg Leu 
465                 470                 475                 480 


Asp Ile Cys Val Lys Asp Gly Ser Glu Arg Thr Trp Ser His Glu Gln 
                485                 490                 495     


Leu Phe Thr Phe Gly Trp Arg Glu Asp Ile Arg Pro Gly Glu Pro Leu 
            500                 505                 510         


His Thr Arg Lys Phe Cys Phe Asp Ala Ile Ser His Asn Ser Pro Val 
        515                 520                 525             


Thr Leu Tyr Asp Cys His Gly Met Lys Gly Asn Gln Leu Trp Gly Tyr 
    530                 535                 540                 


Arg Lys Asp Arg Thr Leu Phe His Pro Val Ser Asn Ser Cys Met Asp 
545                 550                 555                 560 


Cys Asn Pro Ala Glu Lys Lys Ile Phe Met Ala Arg Cys Asp Pro Leu 
                565                 570                 575     


Ser Glu Thr Gln Gln Trp Ile Phe Glu His Ile Asn Met Thr Val Leu 
            580                 585                 590         


Glu Lys Phe Asn His His Ala Asn Ser 
        595                 600     


<210>  5781
<211>  61
<212>  PRT
<213>  Homo Sapiens

<400>  5781

Met Lys Arg Lys Gln Lys Arg Phe Leu Gln Met Thr Leu Leu Phe Thr 
1               5                   10                  15      


Val Ala Leu Ile Phe Leu Pro Asn Val Gly Leu Trp Ser Leu Tyr Lys 
            20                  25                  30          


Asp Lys His Leu Val Lys Ser Ala Glu Pro Gly Glu Gln Gln Val Ser 
        35                  40                  45              


Ala Thr Gln Arg Lys Ile Thr Gln Gly Leu Val Arg Gln 
    50                  55                  60      


<210>  5782
<211>  584
<212>  PRT
<213>  Homo Sapiens

<400>  5782

Met Arg Ala Lys Phe Arg Ala Gly Ala Gly His Gln Arg Asn Pro Ser 
1               5                   10                  15      


Ile Ser Ala Asp His Gly Val His Glu Leu Val Tyr Gln Thr Phe Pro 
            20                  25                  30          


Leu Gly Leu Gly Asp Gly Gln Phe Tyr Ser Trp Thr Asp Gly Leu Arg 
        35                  40                  45              


Arg Lys Asp Trp His Asp Tyr Glu Ser Ile Gln Lys Glu Ala Met Arg 
    50                  55                  60                  


Ser Gly Lys Gly Glu His Gly Lys Pro Tyr Pro Leu Thr Glu Glu Asp 
65                  70                  75                  80  


His Asp Asp Ser Ala Tyr Arg Glu Asn Gly Phe Asn Ile Phe Val Ser 
                85                  90                  95      


Asn Asn Ile Ala Leu Glu Arg Ser Leu Pro Asp Ile Arg His Ala Asn 
            100                 105                 110         


Cys Lys His Lys Met Tyr Leu Glu Arg Leu Pro Asn Thr Ser Ile Ile 
        115                 120                 125             


Ile Pro Phe His Asn Glu Gly Trp Thr Ser Leu Leu Arg Thr Ile His 
    130                 135                 140                 


Ser Ile Ile Asn Arg Thr Pro Gly Ser Leu Ile Ala Glu Ile Ile Leu 
145                 150                 155                 160 


Val Asp Asp Phe Ser Glu Arg Glu His Leu Lys Asp Lys Leu Glu Glu 
                165                 170                 175     


Tyr Met Ala Arg Phe Ser Lys Val Arg Ile Val Arg Thr Lys Lys Arg 
            180                 185                 190         


Glu Gly Leu Ile Arg Thr Arg Leu Leu Gly Ala Ser Met Ala Arg Gly 
        195                 200                 205             


Glu Val Leu Thr Phe Leu Asp Ser His Cys Glu Val Asn Val Asn Trp 
    210                 215                 220                 


Leu Pro Pro Leu Leu Asn Gln Ile Ala Leu Asn His Lys Thr Ile Val 
225                 230                 235                 240 


Cys Pro Met Ile Asp Val Ile Asp His Asn His Phe Gly Tyr Glu Ala 
                245                 250                 255     


Gln Ala Gly Asp Ala Met Arg Gly Ala Phe Asp Trp Glu Met Tyr Tyr 
            260                 265                 270         


Lys Arg Ile Pro Ile Pro Pro Glu Leu Gln Arg Ala Asp Pro Ser Asp 
        275                 280                 285             


Pro Phe Glu Ser Pro Val Met Ala Gly Gly Leu Phe Ala Val Asp Arg 
    290                 295                 300                 


Lys Trp Phe Trp Glu Leu Gly Gly Tyr Asp Pro Gly Leu Glu Ile Trp 
305                 310                 315                 320 


Gly Gly Glu Gln Tyr Glu Ile Ser Phe Lys Val Trp Met Cys Gly Gly 
                325                 330                 335     


Glu Met Phe Asp Val Pro Cys Ser Arg Val Gly His Ile Tyr Arg Lys 
            340                 345                 350         


Tyr Val Pro Tyr Lys Val Pro Ser Gly Thr Ser Leu Ala Arg Asn Leu 
        355                 360                 365             


Lys Arg Val Ala Glu Thr Trp Met Asp Glu Phe Ala Glu Tyr Ile Tyr 
    370                 375                 380                 


Gln Arg Arg Pro Glu Tyr Arg His Leu Ser Thr Gly Asp Ile Ser Ala 
385                 390                 395                 400 


Gln Lys Glu Leu Arg Lys Gln Leu Lys Cys Lys Asp Phe Lys Trp Phe 
                405                 410                 415     


Met Ala Ala Val Ala Trp Asp Val Pro Lys Tyr Tyr Pro Pro Val Glu 
            420                 425                 430         


Pro Pro Pro Ala Ala Trp Gly Glu Ile Arg Asn Val Ala Ala Asn Leu 
        435                 440                 445             


Cys Val Asp Ser Lys His Gly Ala Thr Gly Thr Glu Leu Arg Leu Asp 
    450                 455                 460                 


Ile Cys Val Lys Asp Gly Ser Glu Arg Thr Trp Ser His Glu Gln Leu 
465                 470                 475                 480 


Phe Thr Phe Gly Trp Arg Glu Asp Ile Arg Pro Gly Glu Pro Leu His 
                485                 490                 495     


Thr Arg Lys Phe Cys Phe Asp Ala Ile Ser His Asn Ser Pro Val Thr 
            500                 505                 510         


Leu Tyr Asp Cys His Gly Met Lys Gly Asn Gln Leu Trp Gly Tyr Arg 
        515                 520                 525             


Lys Asp Arg Thr Leu Phe His Pro Val Ser Asn Ser Cys Met Asp Cys 
    530                 535                 540                 


Asn Pro Ala Glu Lys Lys Ile Phe Met Ala Arg Cys Asp Pro Leu Ser 
545                 550                 555                 560 


Glu Thr Gln Gln Trp Ile Phe Glu His Ile Asn Met Thr Val Leu Glu 
                565                 570                 575     


Lys Phe Asn His His Ala Asn Ser 
            580                 


<210>  5783
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  5783

Met Ala Pro Pro Ser Val Pro Leu Val Leu Leu Leu Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Ala Glu Thr Pro Ala Ser Ala Pro Ala His Arg Gly Arg Gly 
            20                  25                  30          


Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Pro Val Leu His 
        35                  40                  45              


Leu Pro Gln Met Gly Asp Gln Asp Gly Lys Arg Glu Thr Ala Leu Glu 
    50                  55                  60                  


Ile Leu Asp Leu Trp Lys Ala Ile Asp Gly Leu Pro Tyr Ser His Pro 
65                  70                  75                  80  


Pro Gln Pro Ser Lys Arg Asn Val Met Glu Thr Phe Ala Lys Pro Glu 
                85                  90                  95      


Ile Gly Asp Leu Gly Met Leu Ser Met Lys Ile Pro Lys Glu Glu Asp 
            100                 105                 110         


Val Leu Lys Ser 
        115     


<210>  5784
<211>  49
<212>  PRT
<213>  Homo Sapiens

<400>  5784

Met Ala Pro Pro Ser Val Pro Leu Val Leu Leu Leu Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Ala Glu Thr Pro Ala Ser Ala Pro Ala His Arg Ser Ser Thr 
            20                  25                  30          


Phe Pro Lys Trp Val Thr Lys Thr Glu Arg Gly Arg Gln Pro Leu Arg 
        35                  40                  45              


Ser 
    


<210>  5785
<211>  49
<212>  PRT
<213>  Homo Sapiens

<400>  5785

Met Ala Pro Pro Ser Val Pro Leu Val Leu Leu Leu Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Ala Glu Thr Pro Ala Ser Ala Pro Ala His Arg Ser Ser Thr 
            20                  25                  30          


Phe Pro Lys Trp Val Thr Lys Thr Glu Arg Gly Arg Gln Pro Leu Arg 
        35                  40                  45              


Ser 
    


<210>  5786
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  5786

Met Ala Ala Val Ala Ala Val Ala Ala Arg Arg Arg Arg Leu Ser Val 
1               5                   10                  15      


Ser Gly Arg Asp Glu Asn Ser Val Glu Leu Thr Met Ala Glu Gly Pro 
            20                  25                  30          


Tyr Lys Ile Ile Leu Thr Ala Arg Pro Phe Arg Leu Asp Leu Leu Glu 
        35                  40                  45              


Asp Arg Ser Leu Leu Leu Ser Val Asn Ala Arg Gly Leu Leu Glu Phe 
    50                  55                  60                  


Glu His Gln Arg Ala Pro Arg Val Ser Phe Ser Asp Lys Val Asn Leu 
65                  70                  75                  80  


Thr Leu Gly Ser Ile Trp Asp Lys Ile Lys Asn Leu Phe Ser Arg Gln 
                85                  90                  95      


Gly Ser Lys Asp Pro Ala Glu Gly Asp Gly Ala Gln Pro Glu Glu Thr 
            100                 105                 110         


Pro Arg Asp Gly Asp Lys Ala 
        115                 


<210>  5787
<211>  852
<212>  PRT
<213>  Homo Sapiens

<400>  5787

Met Ala Ala Val Ala Ala Val Ala Ala Arg Arg Arg Arg Leu Ser Val 
1               5                   10                  15      


Ser Gly Arg Asp Glu Asn Ser Val Glu Leu Thr Met Ala Glu Gly Pro 
            20                  25                  30          


Tyr Lys Ile Ile Leu Thr Ala Arg Pro Phe Arg Leu Asp Leu Leu Glu 
        35                  40                  45              


Asp Arg Ser Leu Leu Leu Ser Val Asn Ala Arg Gly Leu Leu Glu Phe 
    50                  55                  60                  


Glu His Gln Arg Ala Pro Arg Val Ser Phe Ser Asp Lys Val Asn Leu 
65                  70                  75                  80  


Thr Leu Gly Ser Ile Trp Asp Lys Ile Lys Asn Leu Phe Ser Arg Gln 
                85                  90                  95      


Gly Ser Lys Asp Pro Ala Glu Gly Asp Gly Ala Gln Pro Glu Glu Thr 
            100                 105                 110         


Pro Arg Asp Gly Asp Lys Pro Glu Glu Thr Gln Gly Lys Ala Glu Lys 
        115                 120                 125             


Asp Glu Pro Gly Ala Trp Glu Glu Thr Phe Lys Thr His Ser Asp Ser 
    130                 135                 140                 


Lys Pro Tyr Gly Pro Met Ser Val Gly Leu Asp Phe Ser Leu Pro Gly 
145                 150                 155                 160 


Met Glu His Val Tyr Gly Ile Pro Glu His Ala Asp Asn Leu Arg Leu 
                165                 170                 175     


Lys Val Thr Glu Gly Gly Glu Pro Tyr Arg Leu Tyr Asn Leu Asp Val 
            180                 185                 190         


Phe Gln Tyr Glu Leu Tyr Asn Pro Met Ala Leu Tyr Gly Ser Val Pro 
        195                 200                 205             


Val Leu Leu Ala His Asn Pro His Arg Asp Leu Gly Ile Phe Trp Leu 
    210                 215                 220                 


Asn Ala Ala Glu Thr Trp Val Asp Ile Ser Ser Asn Thr Ala Gly Lys 
225                 230                 235                 240 


Thr Leu Phe Gly Lys Met Met Asp Tyr Leu Gln Gly Ser Gly Glu Thr 
                245                 250                 255     


Pro Gln Thr Asp Val Arg Trp Met Ser Glu Thr Gly Ile Ile Asp Val 
            260                 265                 270         


Phe Leu Leu Leu Gly Pro Ser Ile Ser Asp Val Phe Arg Gln Tyr Ala 
        275                 280                 285             


Ser Leu Thr Gly Thr Gln Ala Leu Pro Pro Leu Phe Ser Leu Gly Tyr 
    290                 295                 300                 


His Gln Ser Arg Trp Asn Tyr Arg Asp Glu Ala Asp Val Leu Glu Val 
305                 310                 315                 320 


Asp Gln Gly Phe Asp Asp His Asn Leu Pro Cys Asp Val Ile Trp Leu 
                325                 330                 335     


Asp Ile Glu His Ala Asp Gly Lys Arg Tyr Phe Thr Trp Asp Pro Ser 
            340                 345                 350         


Arg Phe Pro Gln Pro Arg Thr Met Leu Glu Arg Leu Ala Ser Lys Arg 
        355                 360                 365             


Arg Lys Leu Val Ala Ile Val Asp Pro His Ile Lys Val Asp Ser Gly 
    370                 375                 380                 


Tyr Arg Val His Glu Glu Leu Arg Asn Leu Gly Leu Tyr Val Lys Thr 
385                 390                 395                 400 


Arg Asp Gly Ser Asp Tyr Glu Gly Trp Cys Trp Pro Gly Ser Ala Gly 
                405                 410                 415     


Tyr Pro Asp Phe Thr Asn Pro Thr Met Arg Ala Trp Trp Ala Asn Met 
            420                 425                 430         


Phe Ser Tyr Asp Asn Tyr Glu Gly Ser Ala Pro Asn Leu Phe Val Trp 
        435                 440                 445             


Asn Asp Met Asn Glu Pro Ser Val Phe Asn Gly Pro Glu Val Thr Met 
    450                 455                 460                 


Leu Lys Asp Ala Gln His Tyr Gly Gly Trp Glu His Arg Asp Val His 
465                 470                 475                 480 


Asn Ile Tyr Gly Leu Tyr Val His Met Ala Thr Ala Asp Gly Leu Arg 
                485                 490                 495     


Gln Arg Ser Gly Gly Met Glu Arg Pro Phe Val Leu Ala Arg Ala Phe 
            500                 505                 510         


Phe Ala Gly Ser Gln Arg Phe Gly Ala Val Trp Thr Gly Asp Asn Thr 
        515                 520                 525             


Ala Glu Trp Asp His Leu Lys Ile Ser Ile Pro Met Cys Leu Ser Leu 
    530                 535                 540                 


Gly Leu Val Gly Leu Ser Phe Cys Gly Ala Asp Val Gly Gly Phe Phe 
545                 550                 555                 560 


Lys Asn Pro Glu Pro Glu Leu Leu Val Arg Trp Tyr Gln Met Gly Ala 
                565                 570                 575     


Tyr Gln Pro Phe Phe Arg Ala His Ala His Leu Asp Thr Gly Arg Arg 
            580                 585                 590         


Glu Pro Trp Leu Leu Pro Ser Gln His Asn Asp Ile Ile Arg Asp Ala 
        595                 600                 605             


Leu Gly Gln Arg Tyr Ser Leu Leu Pro Phe Trp Tyr Thr Leu Leu Tyr 
    610                 615                 620                 


Gln Ala His Arg Glu Gly Ile Pro Val Met Arg Pro Leu Trp Val Gln 
625                 630                 635                 640 


Tyr Pro Gln Asp Val Thr Thr Phe Asn Ile Asp Asp Gln Tyr Leu Leu 
                645                 650                 655     


Gly Asp Ala Leu Leu Val His Pro Val Ser Asp Ser Gly Ala His Gly 
            660                 665                 670         


Val Gln Val Tyr Leu Pro Gly Gln Gly Glu Val Trp Tyr Asp Ile Gln 
        675                 680                 685             


Ser Tyr Gln Lys His His Gly Pro Gln Thr Leu Tyr Leu Pro Val Thr 
    690                 695                 700                 


Leu Ser Ser Ile Pro Val Phe Gln Arg Gly Gly Thr Ile Val Pro Arg 
705                 710                 715                 720 


Trp Met Arg Val Arg Arg Ser Ser Glu Cys Met Lys Asp Asp Pro Ile 
                725                 730                 735     


Thr Leu Phe Val Ala Leu Ser Pro Gln Gly Thr Ala Gln Gly Glu Leu 
            740                 745                 750         


Phe Leu Asp Asp Gly His Thr Phe Asn Tyr Gln Thr Arg Gln Glu Phe 
        755                 760                 765             


Leu Leu Arg Arg Phe Ser Phe Ser Gly Asn Thr Leu Val Ser Ser Ser 
    770                 775                 780                 


Ala Asp Pro Glu Gly His Phe Glu Thr Pro Ile Trp Ile Glu Arg Val 
785                 790                 795                 800 


Val Ile Ile Gly Ala Gly Lys Pro Ala Ala Val Val Leu Gln Thr Lys 
                805                 810                 815     


Gly Ser Pro Glu Ser Arg Leu Ser Phe Gln His Asp Pro Glu Thr Ser 
            820                 825                 830         


Val Leu Val Leu Arg Lys Pro Gly Ile Asn Val Ala Ser Asp Trp Ser 
        835                 840                 845             


Ile His Leu Arg 
    850         


<210>  5788
<211>  76
<212>  PRT
<213>  Homo Sapiens

<400>  5788

Met Ala Ala Val Ala Ala Val Ala Ala Arg Arg Arg Arg Ser Trp Ala 
1               5                   10                  15      


Ser Leu Val Leu Ala Phe Leu Gly Val Cys Leu Gly Ile Thr Leu Ala 
            20                  25                  30          


Val Asp Arg Ser Asn Phe Lys Thr Cys Glu Glu Ser Ser Phe Cys Asp 
        35                  40                  45              


Arg Glu Ala Tyr Gly Gln Ala Ser Leu His Thr Glu Pro Cys Trp Thr 
    50                  55                  60                  


Leu Tyr Ser Leu Val Leu Ile Pro Ser Arg Ser Ile 
65                  70                  75      


<210>  5789
<211>  52
<212>  PRT
<213>  Homo Sapiens

<400>  5789

Met Ala Ala Val Ala Ala Val Ala Ala Arg Arg Arg Arg Ser Trp Ala 
1               5                   10                  15      


Ser Leu Val Leu Ala Phe Leu Gly Val Cys Leu Gly Ile Thr Leu Ala 
            20                  25                  30          


Val Asp Arg Ser Asn Phe Lys Thr Cys Glu Glu Ser Ser Phe Cys Lys 
        35                  40                  45              


Cys Cys Trp Cys 
    50          


<210>  5790
<211>  52
<212>  PRT
<213>  Homo Sapiens

<400>  5790

Met Ala Ala Val Ala Ala Val Ala Ala Arg Arg Arg Arg Ser Trp Ala 
1               5                   10                  15      


Ser Leu Val Leu Ala Phe Leu Gly Val Cys Leu Gly Ile Thr Leu Ala 
            20                  25                  30          


Val Asp Arg Ser Asn Phe Lys Thr Cys Glu Glu Ser Ser Phe Cys Lys 
        35                  40                  45              


Cys Cys Trp Cys 
    50          


<210>  5791
<211>  52
<212>  PRT
<213>  Homo Sapiens

<400>  5791

Met Ala Ala Val Ala Ala Val Ala Ala Arg Arg Arg Arg Ser Trp Ala 
1               5                   10                  15      


Ser Leu Val Leu Ala Phe Leu Gly Val Cys Leu Gly Ile Thr Leu Ala 
            20                  25                  30          


Val Asp Arg Ser Asn Phe Lys Thr Cys Glu Glu Ser Ser Phe Cys Lys 
        35                  40                  45              


Cys Cys Trp Cys 
    50          


<210>  5792
<211>  966
<212>  PRT
<213>  Homo Sapiens

<400>  5792

Met Ala Ala Val Ala Ala Val Ala Ala Arg Arg Arg Arg Ser Trp Ala 
1               5                   10                  15      


Ser Leu Val Leu Ala Phe Leu Gly Val Cys Leu Gly Ile Thr Leu Ala 
            20                  25                  30          


Val Asp Arg Ser Asn Phe Lys Thr Cys Glu Glu Ser Ser Phe Cys Lys 
        35                  40                  45              


Arg Gln Arg Ser Ile Arg Pro Gly Leu Ser Pro Tyr Arg Ala Leu Leu 
    50                  55                  60                  


Asp Ser Leu Gln Leu Gly Pro Asp Ser Leu Thr Val His Leu Ile His 
65                  70                  75                  80  


Glu Val Thr Lys Val Leu Leu Val Leu Glu Leu Gln Gly Leu Gln Lys 
                85                  90                  95      


Asn Met Thr Arg Phe Arg Ile Asp Glu Leu Glu Pro Arg Arg Pro Arg 
            100                 105                 110         


Tyr Arg Val Pro Asp Val Leu Val Ala Asp Pro Pro Ile Ala Arg Leu 
        115                 120                 125             


Ser Val Ser Gly Arg Asp Glu Asn Ser Val Glu Leu Thr Met Ala Glu 
    130                 135                 140                 


Gly Pro Tyr Lys Ile Ile Leu Thr Ala Arg Pro Phe Arg Leu Asp Leu 
145                 150                 155                 160 


Leu Glu Asp Arg Ser Leu Leu Leu Ser Val Asn Ala Arg Gly Leu Leu 
                165                 170                 175     


Glu Phe Glu His Gln Arg Ala Pro Arg Val Ser Phe Ser Asp Lys Val 
            180                 185                 190         


Asn Leu Thr Leu Gly Ser Ile Trp Asp Lys Ile Lys Asn Leu Phe Ser 
        195                 200                 205             


Arg Gln Gly Ser Lys Asp Pro Ala Glu Gly Asp Gly Ala Gln Pro Glu 
    210                 215                 220                 


Glu Thr Pro Arg Asp Gly Asp Lys Pro Glu Glu Thr Gln Gly Lys Ala 
225                 230                 235                 240 


Glu Lys Asp Glu Pro Gly Ala Trp Glu Glu Thr Phe Lys Thr His Ser 
                245                 250                 255     


Asp Ser Lys Pro Tyr Gly Pro Met Ser Val Gly Leu Asp Phe Ser Leu 
            260                 265                 270         


Pro Gly Met Glu His Val Tyr Gly Ile Pro Glu His Ala Asp Asn Leu 
        275                 280                 285             


Arg Leu Lys Val Thr Glu Gly Gly Glu Pro Tyr Arg Leu Tyr Asn Leu 
    290                 295                 300                 


Asp Val Phe Gln Tyr Glu Leu Tyr Asn Pro Met Ala Leu Tyr Gly Ser 
305                 310                 315                 320 


Val Pro Val Leu Leu Ala His Asn Pro His Arg Asp Leu Gly Ile Phe 
                325                 330                 335     


Trp Leu Asn Ala Ala Glu Thr Trp Val Asp Ile Ser Ser Asn Thr Ala 
            340                 345                 350         


Gly Lys Thr Leu Phe Gly Lys Met Met Asp Tyr Leu Gln Gly Ser Gly 
        355                 360                 365             


Glu Thr Pro Gln Thr Asp Val Arg Trp Met Ser Glu Thr Gly Ile Ile 
    370                 375                 380                 


Asp Val Phe Leu Leu Leu Gly Pro Ser Ile Ser Asp Val Phe Arg Gln 
385                 390                 395                 400 


Tyr Ala Ser Leu Thr Gly Thr Gln Ala Leu Pro Pro Leu Phe Ser Leu 
                405                 410                 415     


Gly Tyr His Gln Ser Arg Trp Asn Tyr Arg Asp Glu Ala Asp Val Leu 
            420                 425                 430         


Glu Val Asp Gln Gly Phe Asp Asp His Asn Leu Pro Cys Asp Val Ile 
        435                 440                 445             


Trp Leu Asp Ile Glu His Ala Asp Gly Lys Arg Tyr Phe Thr Trp Asp 
    450                 455                 460                 


Pro Ser Arg Phe Pro Gln Pro Arg Thr Met Leu Glu Arg Leu Ala Ser 
465                 470                 475                 480 


Lys Arg Arg Lys Leu Val Ala Ile Val Asp Pro His Ile Lys Val Asp 
                485                 490                 495     


Ser Gly Tyr Arg Val His Glu Glu Leu Arg Asn Leu Gly Leu Tyr Val 
            500                 505                 510         


Lys Thr Arg Asp Gly Ser Asp Tyr Glu Gly Trp Cys Trp Pro Gly Ser 
        515                 520                 525             


Ala Gly Tyr Pro Asp Phe Thr Asn Pro Thr Met Arg Ala Trp Trp Ala 
    530                 535                 540                 


Asn Met Phe Ser Tyr Asp Asn Tyr Glu Gly Ser Ala Pro Asn Leu Phe 
545                 550                 555                 560 


Val Trp Asn Asp Met Asn Glu Pro Ser Val Phe Asn Gly Pro Glu Val 
                565                 570                 575     


Thr Met Leu Lys Asp Ala Gln His Tyr Gly Gly Trp Glu His Arg Asp 
            580                 585                 590         


Val His Asn Ile Tyr Gly Leu Tyr Val His Met Ala Thr Ala Asp Gly 
        595                 600                 605             


Leu Arg Gln Arg Ser Gly Gly Met Glu Arg Pro Phe Val Leu Ala Arg 
    610                 615                 620                 


Ala Phe Phe Ala Gly Ser Gln Arg Phe Gly Ala Val Trp Thr Gly Asp 
625                 630                 635                 640 


Asn Thr Ala Glu Trp Asp His Leu Lys Ile Ser Ile Pro Met Cys Leu 
                645                 650                 655     


Ser Leu Gly Leu Val Gly Leu Ser Phe Cys Gly Ala Asp Val Gly Gly 
            660                 665                 670         


Phe Phe Lys Asn Pro Glu Pro Glu Leu Leu Val Arg Trp Tyr Gln Met 
        675                 680                 685             


Gly Ala Tyr Gln Pro Phe Phe Arg Ala His Ala His Leu Asp Thr Gly 
    690                 695                 700                 


Arg Arg Glu Pro Trp Leu Leu Pro Ser Gln His Asn Asp Ile Ile Arg 
705                 710                 715                 720 


Asp Ala Leu Gly Gln Arg Tyr Ser Leu Leu Pro Phe Trp Tyr Thr Leu 
                725                 730                 735     


Leu Tyr Gln Ala His Arg Glu Gly Ile Pro Val Met Arg Pro Leu Trp 
            740                 745                 750         


Val Gln Tyr Pro Gln Asp Val Thr Thr Phe Asn Ile Asp Asp Gln Tyr 
        755                 760                 765             


Leu Leu Gly Asp Ala Leu Leu Val His Pro Val Ser Asp Ser Gly Ala 
    770                 775                 780                 


His Gly Val Gln Val Tyr Leu Pro Gly Gln Gly Glu Val Trp Tyr Asp 
785                 790                 795                 800 


Ile Gln Ser Tyr Gln Lys His His Gly Pro Gln Thr Leu Tyr Leu Pro 
                805                 810                 815     


Val Thr Leu Ser Ser Ile Pro Val Phe Gln Arg Gly Gly Thr Ile Val 
            820                 825                 830         


Pro Arg Trp Met Arg Val Arg Arg Ser Ser Glu Cys Met Lys Asp Asp 
        835                 840                 845             


Pro Ile Thr Leu Phe Val Ala Leu Ser Pro Gln Gly Thr Ala Gln Gly 
    850                 855                 860                 


Glu Leu Phe Leu Asp Asp Gly His Thr Phe Asn Tyr Gln Thr Arg Gln 
865                 870                 875                 880 


Glu Phe Leu Leu Arg Arg Phe Ser Phe Ser Gly Asn Thr Leu Val Ser 
                885                 890                 895     


Ser Ser Ala Asp Pro Glu Gly His Phe Glu Thr Pro Ile Trp Ile Glu 
            900                 905                 910         


Arg Val Val Ile Ile Gly Ala Gly Lys Pro Ala Ala Val Val Leu Gln 
        915                 920                 925             


Thr Lys Gly Ser Pro Glu Ser Arg Leu Ser Phe Gln His Asp Pro Glu 
    930                 935                 940                 


Thr Ser Val Leu Val Leu Arg Lys Pro Gly Ile Asn Val Ala Ser Asp 
945                 950                 955                 960 


Trp Ser Ile His Leu Arg 
                965     


<210>  5793
<211>  944
<212>  PRT
<213>  Homo Sapiens

<400>  5793

Met Ala Ala Val Ala Ala Val Ala Ala Arg Arg Arg Arg Ser Trp Ala 
1               5                   10                  15      


Ser Leu Val Leu Ala Phe Leu Gly Val Cys Leu Gly Ile Thr Leu Ala 
            20                  25                  30          


Val Asp Arg Ser Asn Phe Lys Thr Cys Glu Glu Ser Ser Phe Cys Lys 
        35                  40                  45              


Arg Gln Arg Ser Ile Arg Pro Gly Leu Ser Pro Tyr Arg Ala Leu Leu 
    50                  55                  60                  


Asp Ser Leu Gln Leu Gly Pro Asp Ser Leu Thr Val His Leu Ile His 
65                  70                  75                  80  


Glu Val Thr Lys Val Leu Leu Val Leu Glu Leu Gln Gly Leu Gln Lys 
                85                  90                  95      


Asn Met Thr Arg Phe Arg Ile Asp Glu Leu Glu Pro Arg Arg Pro Arg 
            100                 105                 110         


Tyr Arg Val Pro Asp Val Leu Val Ala Asp Pro Pro Ile Ala Arg Leu 
        115                 120                 125             


Ser Val Ser Gly Arg Asp Glu Asn Ser Val Glu Leu Thr Met Ala Glu 
    130                 135                 140                 


Gly Pro Tyr Lys Ile Ile Leu Thr Ala Arg Pro Phe Arg Leu Asp Leu 
145                 150                 155                 160 


Leu Glu Asp Arg Ser Leu Leu Leu Ser Val Asn Ala Arg Gly Leu Leu 
                165                 170                 175     


Glu Phe Glu His Gln Arg Ala Pro Arg Val Ser Gln Gly Ser Lys Asp 
            180                 185                 190         


Pro Ala Glu Gly Asp Gly Ala Gln Pro Glu Glu Thr Pro Arg Asp Gly 
        195                 200                 205             


Asp Lys Pro Glu Glu Thr Gln Gly Lys Ala Glu Lys Asp Glu Pro Gly 
    210                 215                 220                 


Ala Trp Glu Glu Thr Phe Lys Thr His Ser Asp Ser Lys Pro Tyr Gly 
225                 230                 235                 240 


Pro Met Ser Val Gly Leu Asp Phe Ser Leu Pro Gly Met Glu His Val 
                245                 250                 255     


Tyr Gly Ile Pro Glu His Ala Asp Asn Leu Arg Leu Lys Val Thr Glu 
            260                 265                 270         


Gly Gly Glu Pro Tyr Arg Leu Tyr Asn Leu Asp Val Phe Gln Tyr Glu 
        275                 280                 285             


Leu Tyr Asn Pro Met Ala Leu Tyr Gly Ser Val Pro Val Leu Leu Ala 
    290                 295                 300                 


His Asn Pro His Arg Asp Leu Gly Ile Phe Trp Leu Asn Ala Ala Glu 
305                 310                 315                 320 


Thr Trp Val Asp Ile Ser Ser Asn Thr Ala Gly Lys Thr Leu Phe Gly 
                325                 330                 335     


Lys Met Met Asp Tyr Leu Gln Gly Ser Gly Glu Thr Pro Gln Thr Asp 
            340                 345                 350         


Val Arg Trp Met Ser Glu Thr Gly Ile Ile Asp Val Phe Leu Leu Leu 
        355                 360                 365             


Gly Pro Ser Ile Ser Asp Val Phe Arg Gln Tyr Ala Ser Leu Thr Gly 
    370                 375                 380                 


Thr Gln Ala Leu Pro Pro Leu Phe Ser Leu Gly Tyr His Gln Ser Arg 
385                 390                 395                 400 


Trp Asn Tyr Arg Asp Glu Ala Asp Val Leu Glu Val Asp Gln Gly Phe 
                405                 410                 415     


Asp Asp His Asn Leu Pro Cys Asp Val Ile Trp Leu Asp Ile Glu His 
            420                 425                 430         


Ala Asp Gly Lys Arg Tyr Phe Thr Trp Asp Pro Ser Arg Phe Pro Gln 
        435                 440                 445             


Pro Arg Thr Met Leu Glu Arg Leu Ala Ser Lys Arg Arg Lys Leu Val 
    450                 455                 460                 


Ala Ile Val Asp Pro His Ile Lys Val Asp Ser Gly Tyr Arg Val His 
465                 470                 475                 480 


Glu Glu Leu Arg Asn Leu Gly Leu Tyr Val Lys Thr Arg Asp Gly Ser 
                485                 490                 495     


Asp Tyr Glu Gly Trp Cys Trp Pro Gly Ser Ala Gly Tyr Pro Asp Phe 
            500                 505                 510         


Thr Asn Pro Thr Met Arg Ala Trp Trp Ala Asn Met Phe Ser Tyr Asp 
        515                 520                 525             


Asn Tyr Glu Gly Ser Ala Pro Asn Leu Phe Val Trp Asn Asp Met Asn 
    530                 535                 540                 


Glu Pro Ser Val Phe Asn Gly Pro Glu Val Thr Met Leu Lys Asp Ala 
545                 550                 555                 560 


Gln His Tyr Gly Gly Trp Glu His Arg Asp Val His Asn Ile Tyr Gly 
                565                 570                 575     


Leu Tyr Val His Met Ala Thr Ala Asp Gly Leu Arg Gln Arg Ser Gly 
            580                 585                 590         


Gly Met Glu Arg Pro Phe Val Leu Ala Arg Ala Phe Phe Ala Gly Ser 
        595                 600                 605             


Gln Arg Phe Gly Ala Val Trp Thr Gly Asp Asn Thr Ala Glu Trp Asp 
    610                 615                 620                 


His Leu Lys Ile Ser Ile Pro Met Cys Leu Ser Leu Gly Leu Val Gly 
625                 630                 635                 640 


Leu Ser Phe Cys Gly Ala Asp Val Gly Gly Phe Phe Lys Asn Pro Glu 
                645                 650                 655     


Pro Glu Leu Leu Val Arg Trp Tyr Gln Met Gly Ala Tyr Gln Pro Phe 
            660                 665                 670         


Phe Arg Ala His Ala His Leu Asp Thr Gly Arg Arg Glu Pro Trp Leu 
        675                 680                 685             


Leu Pro Ser Gln His Asn Asp Ile Ile Arg Asp Ala Leu Gly Gln Arg 
    690                 695                 700                 


Tyr Ser Leu Leu Pro Phe Trp Tyr Thr Leu Leu Tyr Gln Ala His Arg 
705                 710                 715                 720 


Glu Gly Ile Pro Val Met Arg Pro Leu Trp Val Gln Tyr Pro Gln Asp 
                725                 730                 735     


Val Thr Thr Phe Asn Ile Asp Asp Gln Tyr Leu Leu Gly Asp Ala Leu 
            740                 745                 750         


Leu Val His Pro Val Ser Asp Ser Gly Ala His Gly Val Gln Val Tyr 
        755                 760                 765             


Leu Pro Gly Gln Gly Glu Val Trp Tyr Asp Ile Gln Ser Tyr Gln Lys 
    770                 775                 780                 


His His Gly Pro Gln Thr Leu Tyr Leu Pro Val Thr Leu Ser Ser Ile 
785                 790                 795                 800 


Pro Val Phe Gln Arg Gly Gly Thr Ile Val Pro Arg Trp Met Arg Val 
                805                 810                 815     


Arg Arg Ser Ser Glu Cys Met Lys Asp Asp Pro Ile Thr Leu Phe Val 
            820                 825                 830         


Ala Leu Ser Pro Gln Gly Thr Ala Gln Gly Glu Leu Phe Leu Asp Asp 
        835                 840                 845             


Gly His Thr Phe Asn Tyr Gln Thr Arg Gln Glu Phe Leu Leu Arg Arg 
    850                 855                 860                 


Phe Ser Phe Ser Gly Asn Thr Leu Val Ser Ser Ser Ala Asp Pro Glu 
865                 870                 875                 880 


Gly His Phe Glu Thr Pro Ile Trp Ile Glu Arg Val Val Ile Ile Gly 
                885                 890                 895     


Ala Gly Lys Pro Ala Ala Val Val Leu Gln Thr Lys Gly Ser Pro Glu 
            900                 905                 910         


Ser Arg Leu Ser Phe Gln His Asp Pro Glu Thr Ser Val Leu Val Leu 
        915                 920                 925             


Arg Lys Pro Gly Ile Asn Val Ala Ser Asp Trp Ser Ile His Leu Arg 
    930                 935                 940                 


<210>  5794
<211>  847
<212>  PRT
<213>  Homo Sapiens

<400>  5794

Met Thr Arg Phe Arg Ile Asp Glu Leu Glu Pro Arg Arg Pro Arg Tyr 
1               5                   10                  15      


Arg Val Pro Asp Val Leu Val Ala Asp Pro Pro Ile Ala Arg Leu Ser 
            20                  25                  30          


Val Ser Gly Arg Asp Glu Asn Ser Val Glu Leu Thr Met Ala Glu Gly 
        35                  40                  45              


Pro Tyr Lys Ile Ile Leu Thr Ala Arg Pro Phe Arg Leu Asp Leu Leu 
    50                  55                  60                  


Glu Asp Arg Ser Leu Leu Leu Ser Val Asn Ala Arg Gly Leu Leu Glu 
65                  70                  75                  80  


Phe Glu His Gln Arg Ala Pro Arg Val Ser Gln Gly Ser Lys Asp Pro 
                85                  90                  95      


Ala Glu Gly Asp Gly Ala Gln Pro Glu Glu Thr Pro Arg Asp Gly Asp 
            100                 105                 110         


Lys Pro Glu Glu Thr Gln Gly Lys Ala Glu Lys Asp Glu Pro Gly Ala 
        115                 120                 125             


Trp Glu Glu Thr Phe Lys Thr His Ser Asp Ser Lys Pro Tyr Gly Pro 
    130                 135                 140                 


Met Ser Val Gly Leu Asp Phe Ser Leu Pro Gly Met Glu His Val Tyr 
145                 150                 155                 160 


Gly Ile Pro Glu His Ala Asp Asn Leu Arg Leu Lys Val Thr Glu Gly 
                165                 170                 175     


Gly Glu Pro Tyr Arg Leu Tyr Asn Leu Asp Val Phe Gln Tyr Glu Leu 
            180                 185                 190         


Tyr Asn Pro Met Ala Leu Tyr Gly Ser Val Pro Val Leu Leu Ala His 
        195                 200                 205             


Asn Pro His Arg Asp Leu Gly Ile Phe Trp Leu Asn Ala Ala Glu Thr 
    210                 215                 220                 


Trp Val Asp Ile Ser Ser Asn Thr Ala Gly Lys Thr Leu Phe Gly Lys 
225                 230                 235                 240 


Met Met Asp Tyr Leu Gln Gly Ser Gly Glu Thr Pro Gln Thr Asp Val 
                245                 250                 255     


Arg Trp Met Ser Glu Thr Gly Ile Ile Asp Val Phe Leu Leu Leu Gly 
            260                 265                 270         


Pro Ser Ile Ser Asp Val Phe Arg Gln Tyr Ala Ser Leu Thr Gly Thr 
        275                 280                 285             


Gln Ala Leu Pro Pro Leu Phe Ser Leu Gly Tyr His Gln Ser Arg Trp 
    290                 295                 300                 


Asn Tyr Arg Asp Glu Ala Asp Val Leu Glu Val Asp Gln Gly Phe Asp 
305                 310                 315                 320 


Asp His Asn Leu Pro Cys Asp Val Ile Trp Leu Asp Ile Glu His Ala 
                325                 330                 335     


Asp Gly Lys Arg Tyr Phe Thr Trp Asp Pro Ser Arg Phe Pro Gln Pro 
            340                 345                 350         


Arg Thr Met Leu Glu Arg Leu Ala Ser Lys Arg Arg Lys Leu Val Ala 
        355                 360                 365             


Ile Val Asp Pro His Ile Lys Val Asp Ser Gly Tyr Arg Val His Glu 
    370                 375                 380                 


Glu Leu Arg Asn Leu Gly Leu Tyr Val Lys Thr Arg Asp Gly Ser Asp 
385                 390                 395                 400 


Tyr Glu Gly Trp Cys Trp Pro Gly Ser Ala Gly Tyr Pro Asp Phe Thr 
                405                 410                 415     


Asn Pro Thr Met Arg Ala Trp Trp Ala Asn Met Phe Ser Tyr Asp Asn 
            420                 425                 430         


Tyr Glu Gly Ser Ala Pro Asn Leu Phe Val Trp Asn Asp Met Asn Glu 
        435                 440                 445             


Pro Ser Val Phe Asn Gly Pro Glu Val Thr Met Leu Lys Asp Ala Gln 
    450                 455                 460                 


His Tyr Gly Gly Trp Glu His Arg Asp Val His Asn Ile Tyr Gly Leu 
465                 470                 475                 480 


Tyr Val His Met Ala Thr Ala Asp Gly Leu Arg Gln Arg Ser Gly Gly 
                485                 490                 495     


Met Glu Arg Pro Phe Val Leu Ala Arg Ala Phe Phe Ala Gly Ser Gln 
            500                 505                 510         


Arg Phe Gly Ala Val Trp Thr Gly Asp Asn Thr Ala Glu Trp Asp His 
        515                 520                 525             


Leu Lys Ile Ser Ile Pro Met Cys Leu Ser Leu Gly Leu Val Gly Leu 
    530                 535                 540                 


Ser Phe Cys Gly Ala Asp Val Gly Gly Phe Phe Lys Asn Pro Glu Pro 
545                 550                 555                 560 


Glu Leu Leu Val Arg Trp Tyr Gln Met Gly Ala Tyr Gln Pro Phe Phe 
                565                 570                 575     


Arg Ala His Ala His Leu Asp Thr Gly Arg Arg Glu Pro Trp Leu Leu 
            580                 585                 590         


Pro Ser Gln His Asn Asp Ile Ile Arg Asp Ala Leu Gly Gln Arg Tyr 
        595                 600                 605             


Ser Leu Leu Pro Phe Trp Tyr Thr Leu Leu Tyr Gln Ala His Arg Glu 
    610                 615                 620                 


Gly Ile Pro Val Met Arg Pro Leu Trp Val Gln Tyr Pro Gln Asp Val 
625                 630                 635                 640 


Thr Thr Phe Asn Ile Asp Asp Gln Tyr Leu Leu Gly Asp Ala Leu Leu 
                645                 650                 655     


Val His Pro Val Ser Asp Ser Gly Ala His Gly Val Gln Val Tyr Leu 
            660                 665                 670         


Pro Gly Gln Gly Glu Val Trp Tyr Asp Ile Gln Ser Tyr Gln Lys His 
        675                 680                 685             


His Gly Pro Gln Thr Leu Tyr Leu Pro Val Thr Leu Ser Ser Ile Pro 
    690                 695                 700                 


Val Phe Gln Arg Gly Gly Thr Ile Val Pro Arg Trp Met Arg Val Arg 
705                 710                 715                 720 


Arg Ser Ser Glu Cys Met Lys Asp Asp Pro Ile Thr Leu Phe Val Ala 
                725                 730                 735     


Leu Ser Pro Gln Gly Thr Ala Gln Gly Glu Leu Phe Leu Asp Asp Gly 
            740                 745                 750         


His Thr Phe Asn Tyr Gln Thr Arg Gln Glu Phe Leu Leu Arg Arg Phe 
        755                 760                 765             


Ser Phe Ser Gly Asn Thr Leu Val Ser Ser Ser Ala Asp Pro Glu Gly 
    770                 775                 780                 


His Phe Glu Thr Pro Ile Trp Ile Glu Arg Val Val Ile Ile Gly Ala 
785                 790                 795                 800 


Gly Lys Pro Ala Ala Val Val Leu Gln Thr Lys Gly Ser Pro Glu Ser 
                805                 810                 815     


Arg Leu Ser Phe Gln His Asp Pro Glu Thr Ser Val Leu Val Leu Arg 
            820                 825                 830         


Lys Pro Gly Ile Asn Val Ala Ser Asp Trp Ser Ile His Leu Arg 
        835                 840                 845         


<210>  5795
<211>  79
<212>  PRT
<213>  Homo Sapiens

<400>  5795

Met Pro Ser Pro Arg Pro Val Leu Leu Arg Gly Ala Arg Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Leu Pro Pro Arg Leu Leu Ala Arg Pro Ser Leu Leu Leu 
            20                  25                  30          


Arg Arg Ser Leu Ser Ala Ala Ser Cys Pro Pro Ile Ser Leu Pro Ala 
        35                  40                  45              


Ala Ala Ser Arg Ser Ser Met Asp Gly Ala Gly Ala Glu Glu Val Leu 
    50                  55                  60                  


Ala Pro Leu Arg Leu Ala Val Arg Gln Gln Ala Val Trp Asn Gln 
65                  70                  75                  


<210>  5796
<211>  79
<212>  PRT
<213>  Homo Sapiens

<400>  5796

Met Pro Ser Pro Arg Pro Val Leu Leu Arg Gly Ala Arg Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Leu Pro Pro Arg Leu Leu Ala Arg Pro Ser Leu Leu Leu 
            20                  25                  30          


Arg Arg Ser Leu Ser Ala Ala Ser Cys Pro Pro Ile Ser Leu Pro Ala 
        35                  40                  45              


Ala Ala Ser Arg Ser Ser Met Asp Gly Ala Gly Ala Glu Glu Val Leu 
    50                  55                  60                  


Ala Pro Leu Arg Leu Ala Val Arg Gln Gln Ala Val Trp Asn Gln 
65                  70                  75                  


<210>  5797
<211>  739
<212>  PRT
<213>  Homo Sapiens

<400>  5797

Met Pro Ser Pro Arg Pro Val Leu Leu Arg Gly Ala Arg Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Leu Pro Pro Arg Leu Leu Ala Arg Pro Ser Leu Leu Leu 
            20                  25                  30          


Arg Arg Ser Leu Ser Ala Ala Ser Cys Pro Pro Ile Ser Leu Pro Ala 
        35                  40                  45              


Ala Ala Ser Arg Ser Ser Met Asp Gly Ala Gly Ala Glu Glu Val Leu 
    50                  55                  60                  


Ala Pro Leu Arg Leu Ala Val Arg Gln Gln Gly Asp Leu Val Arg Lys 
65                  70                  75                  80  


Leu Lys Glu Asp Lys Ala Pro Gln Val Asp Val Asp Lys Ala Val Ala 
                85                  90                  95      


Glu Leu Lys Ala Arg Lys Arg Val Leu Glu Ala Lys Glu Leu Ala Leu 
            100                 105                 110         


Gln Pro Lys Asp Asp Ile Val Asp Arg Ala Lys Met Glu Asp Thr Leu 
        115                 120                 125             


Lys Arg Arg Phe Phe Tyr Asp Gln Ala Phe Ala Ile Tyr Gly Gly Val 
    130                 135                 140                 


Ser Gly Leu Tyr Asp Phe Gly Pro Val Gly Cys Ala Leu Lys Asn Asn 
145                 150                 155                 160 


Ile Ile Gln Thr Trp Arg Gln His Phe Ile Gln Glu Glu Gln Ile Leu 
                165                 170                 175     


Glu Ile Asp Cys Thr Met Leu Thr Pro Glu Pro Val Leu Lys Thr Ser 
            180                 185                 190         


Gly His Val Asp Lys Phe Ala Asp Phe Met Val Lys Asp Val Lys Asn 
        195                 200                 205             


Gly Glu Cys Phe Arg Ala Asp His Leu Leu Lys Ala His Leu Gln Lys 
    210                 215                 220                 


Leu Met Ser Asp Lys Lys Cys Ser Val Glu Lys Lys Ser Glu Met Glu 
225                 230                 235                 240 


Ser Val Leu Ala Gln Leu Asp Asn Tyr Gly Gln Gln Glu Leu Ala Asp 
                245                 250                 255     


Leu Phe Val Asn Tyr Asn Val Lys Ser Pro Ile Thr Gly Asn Asp Leu 
            260                 265                 270         


Ser Pro Pro Val Ser Phe Asn Leu Met Phe Lys Thr Phe Ile Gly Pro 
        275                 280                 285             


Gly Gly Asn Met Pro Gly Tyr Leu Arg Pro Glu Thr Ala Gln Gly Ile 
    290                 295                 300                 


Phe Leu Asn Phe Lys Arg Leu Leu Glu Phe Asn Gln Gly Lys Leu Pro 
305                 310                 315                 320 


Phe Ala Ala Ala Gln Ile Gly Asn Ser Phe Arg Asn Glu Ile Ser Pro 
                325                 330                 335     


Arg Ser Gly Leu Ile Arg Val Arg Glu Phe Thr Met Ala Glu Ile Glu 
            340                 345                 350         


His Phe Val Asp Pro Ser Glu Lys Asp His Pro Lys Phe Gln Asn Val 
        355                 360                 365             


Ala Asp Leu His Leu Tyr Leu Tyr Ser Ala Lys Ala Gln Val Ser Gly 
    370                 375                 380                 


Gln Ser Ala Arg Lys Met Arg Leu Gly Asp Ala Val Glu Gln Gly Val 
385                 390                 395                 400 


Ile Asn Asn Thr Val Leu Gly Tyr Phe Ile Gly Arg Ile Tyr Leu Tyr 
                405                 410                 415     


Leu Thr Lys Val Gly Ile Ser Pro Asp Lys Leu Arg Phe Arg Gln His 
            420                 425                 430         


Met Glu Asn Glu Met Ala His Tyr Ala Cys Asp Cys Trp Asp Ala Glu 
        435                 440                 445             


Ser Lys Thr Ser Tyr Gly Trp Ile Glu Ile Val Gly Cys Ala Asp Arg 
    450                 455                 460                 


Ser Cys Tyr Asp Leu Ser Cys His Ala Arg Ala Thr Lys Val Pro Leu 
465                 470                 475                 480 


Val Ala Glu Lys Pro Leu Lys Glu Pro Lys Thr Val Asn Val Val Gln 
                485                 490                 495     


Phe Glu Pro Ser Lys Gly Ala Ile Gly Lys Ala Tyr Lys Lys Asp Ala 
            500                 505                 510         


Lys Leu Val Met Glu Tyr Leu Ala Ile Cys Asp Glu Cys Tyr Ile Thr 
        515                 520                 525             


Glu Met Glu Met Leu Leu Asn Glu Lys Gly Glu Phe Thr Ile Glu Thr 
    530                 535                 540                 


Glu Gly Lys Thr Phe Gln Leu Thr Lys Asp Met Ile Asn Val Lys Arg 
545                 550                 555                 560 


Phe Gln Lys Thr Leu Tyr Val Glu Glu Val Val Pro Asn Val Ile Glu 
                565                 570                 575     


Pro Ser Phe Gly Leu Gly Arg Ile Met Tyr Thr Val Phe Glu His Thr 
            580                 585                 590         


Phe His Val Arg Glu Gly Asp Glu Gln Arg Thr Phe Phe Ser Phe Pro 
        595                 600                 605             


Ala Val Val Ala Pro Phe Lys Cys Ser Val Leu Pro Leu Ser Gln Asn 
    610                 615                 620                 


Gln Glu Phe Met Pro Phe Val Lys Glu Leu Ser Glu Ala Leu Thr Arg 
625                 630                 635                 640 


His Gly Val Ser His Lys Val Asp Asp Ser Ser Gly Ser Ile Gly Arg 
                645                 650                 655     


Arg Tyr Ala Arg Thr Asp Glu Ile Gly Val Ala Phe Gly Val Thr Ile 
            660                 665                 670         


Asp Phe Asp Thr Val Asn Lys Thr Pro His Thr Ala Thr Leu Arg Asp 
        675                 680                 685             


Arg Asp Ser Met Arg Gln Ile Arg Ala Glu Ile Ser Glu Leu Pro Ser 
    690                 695                 700                 


Ile Val Gln Asp Leu Ala Asn Gly Asn Ile Thr Trp Ala Asp Val Glu 
705                 710                 715                 720 


Ala Arg Tyr Pro Leu Phe Glu Gly Gln Glu Thr Gly Lys Lys Glu Thr 
                725                 730                 735     


Ile Glu Glu 
            


<210>  5798
<211>  77
<212>  PRT
<213>  Homo Sapiens

<400>  5798

Val Val Gln Phe Glu Pro Ser Lys Gly Ala Ile Gly Lys Ala Tyr Lys 
1               5                   10                  15      


Lys Asp Ala Lys Leu Val Met Glu Tyr Leu Ala Ile Cys Asp Glu Cys 
            20                  25                  30          


Tyr Ile Thr Glu Met Glu Met Leu Leu Asn Glu Lys Gly Glu Phe Thr 
        35                  40                  45              


Ile Glu Thr Glu Gly Lys Thr Phe Gln Leu Thr Lys Asp Met Ile Asn 
    50                  55                  60                  


Val Lys Arg Phe Gln Lys Thr Leu Tyr Glu Gln Ile Leu 
65                  70                  75          


<210>  5799
<211>  345
<212>  PRT
<213>  Homo Sapiens

<400>  5799

Met Val Ala Ala Leu Leu Gly Gly Gly Gly Glu Ala Arg Gly Gly Thr 
1               5                   10                  15      


Val Pro Gly Ala Trp Leu Cys Leu Met Ala Leu Leu Gln Leu Leu Gly 
            20                  25                  30          


Ser Ala Pro Arg Gly Ser Gly Leu Ala His Gly Arg Arg Leu Ile Cys 
        35                  40                  45              


Trp Gln Ala Leu Leu Gln Cys Gln Gly Glu Pro Glu Cys Ser Tyr Ala 
    50                  55                  60                  


Tyr Asn Gln Tyr Ala Glu Ala Cys Ala Pro Val Leu Ala Gln His Gly 
65                  70                  75                  80  


Gly Gly Asp Ala Pro Gly Ala Ala Ala Ala Ala Phe Pro Ala Ser Ala 
                85                  90                  95      


Ala Ser Phe Ser Ser Arg Trp Arg Cys Pro Ser His Cys Ile Ser Ala 
            100                 105                 110         


Leu Ile Gln Leu Asn His Thr Arg Arg Gly Pro Ala Leu Glu Asp Cys 
        115                 120                 125             


Asp Cys Ala Gln Asp Glu Asn Cys Lys Ser Thr Lys Arg Ala Ile Glu 
    130                 135                 140                 


Pro Cys Leu Pro Arg Thr Ser Gly Gly Gly Ala Gly Gly Pro Gly Ala 
145                 150                 155                 160 


Gly Gly Val Met Gly Cys Thr Glu Ala Arg Arg Arg Cys Asp Arg Asp 
                165                 170                 175     


Ser Arg Cys Asn Leu Ala Leu Ser Arg Tyr Leu Thr Tyr Cys Gly Lys 
            180                 185                 190         


Val Phe Asn Gly Leu Arg Cys Thr Asp Glu Cys Arg Thr Val Ile Glu 
        195                 200                 205             


Asp Met Leu Ala Met Pro Lys Ala Ala Leu Leu Asn Asp Cys Val Cys 
    210                 215                 220                 


Asp Gly Leu Glu Arg Pro Ile Cys Glu Ser Val Lys Glu Asn Met Ala 
225                 230                 235                 240 


Arg Leu Cys Phe Gly Ala Glu Leu Gly Asn Gly Pro Gly Ser Ser Gly 
                245                 250                 255     


Ser Asp Gly Gly Leu Asp Asp Tyr Tyr Asp Glu Asp Tyr Asp Asp Glu 
            260                 265                 270         


Gln Arg Thr Gly Gly Ala Gly Gly Glu Gln Pro Leu Asp Asp Asp Asp 
        275                 280                 285             


Gly Val Pro His Pro Pro Arg Pro Gly Ser Gly Ala Ala Ala Ser Gly 
    290                 295                 300                 


Gly Arg Gly Asp Leu Pro Tyr Gly Pro Gly Arg Arg Ser Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Arg Leu Ala Pro Arg Gly Ala Trp Thr Pro Leu Ala Ser Ile 
                325                 330                 335     


Leu Leu Leu Leu Leu Gly Pro Leu Phe 
            340                 345 


<210>  5800
<211>  678
<212>  PRT
<213>  Homo Sapiens

<400>  5800

Met Ala Pro Ser Leu Ser Pro Gly Pro Ala Ala Leu Arg Arg Ala Pro 
1               5                   10                  15      


Gln Leu Leu Leu Leu Leu Leu Ala Ala Glu Cys Ala Leu Ala Ala Leu 
            20                  25                  30          


Leu Pro Ala Arg Glu Ala Thr Gln Phe Leu Arg Pro Arg Gln Arg Arg 
        35                  40                  45              


Ala Phe Gln Val Phe Glu Glu Ala Lys Gln Gly His Leu Glu Arg Glu 
    50                  55                  60                  


Cys Val Glu Glu Leu Cys Ser Arg Glu Glu Ala Arg Glu Val Phe Glu 
65                  70                  75                  80  


Asn Asp Pro Glu Thr Asp Tyr Phe Tyr Pro Arg Tyr Leu Asp Cys Ile 
                85                  90                  95      


Asn Lys Tyr Gly Ser Pro Tyr Thr Lys Asn Ser Gly Phe Ala Thr Cys 
            100                 105                 110         


Val Gln Asn Leu Pro Asp Gln Cys Thr Pro Asn Pro Cys Asp Arg Lys 
        115                 120                 125             


Gly Thr Gln Ala Cys Gln Asp Leu Met Gly Asn Phe Phe Cys Leu Cys 
    130                 135                 140                 


Lys Ala Gly Trp Gly Gly Arg Leu Cys Asp Lys Asp Val Asn Glu Cys 
145                 150                 155                 160 


Ser Gln Glu Asn Gly Gly Cys Leu Gln Ile Cys His Asn Lys Pro Gly 
                165                 170                 175     


Ser Phe His Cys Ser Cys His Ser Gly Phe Glu Leu Ser Ser Asp Gly 
            180                 185                 190         


Arg Thr Cys Gln Asp Ile Asp Glu Cys Ala Asp Ser Glu Ala Cys Gly 
        195                 200                 205             


Glu Ala Arg Cys Lys Asn Leu Pro Gly Ser Tyr Ser Cys Leu Cys Asp 
    210                 215                 220                 


Glu Gly Phe Ala Tyr Ser Ser Gln Glu Lys Ala Cys Arg Asp Val Asp 
225                 230                 235                 240 


Glu Cys Leu Gln Gly Arg Cys Glu Gln Val Cys Val Asn Ser Pro Gly 
                245                 250                 255     


Ser Tyr Thr Cys His Cys Asp Gly Arg Gly Gly Leu Lys Leu Ser Gln 
            260                 265                 270         


Asp Met Asp Thr Cys Glu Asp Ile Leu Pro Cys Val Pro Phe Ser Val 
        275                 280                 285             


Ala Lys Ser Val Lys Ser Leu Tyr Leu Gly Arg Met Phe Ser Gly Thr 
    290                 295                 300                 


Pro Val Ile Arg Leu Arg Phe Lys Arg Leu Gln Pro Thr Arg Leu Val 
305                 310                 315                 320 


Ala Glu Phe Asp Phe Arg Thr Phe Asp Pro Glu Gly Ile Leu Leu Phe 
                325                 330                 335     


Ala Gly Gly His Gln Asp Ser Thr Trp Ile Val Leu Ala Leu Arg Ala 
            340                 345                 350         


Gly Arg Leu Glu Leu Gln Leu Arg Tyr Asn Gly Val Gly Arg Val Thr 
        355                 360                 365             


Ser Ser Gly Pro Val Ile Asn His Gly Met Trp Gln Thr Ile Ser Val 
    370                 375                 380                 


Glu Glu Leu Ala Arg Asn Leu Val Ile Lys Val Asn Arg Asp Ala Val 
385                 390                 395                 400 


Met Lys Ile Ala Val Ala Gly Asp Leu Phe Gln Pro Glu Arg Gly Leu 
                405                 410                 415     


Tyr His Leu Asn Leu Thr Val Gly Gly Ile Pro Phe His Glu Lys Asp 
            420                 425                 430         


Leu Val Gln Pro Ile Asn Pro Arg Leu Asp Gly Cys Met Arg Ser Trp 
        435                 440                 445             


Asn Trp Leu Asn Gly Glu Asp Thr Thr Ile Gln Glu Thr Val Lys Val 
    450                 455                 460                 


Asn Thr Arg Met Gln Cys Phe Ser Val Thr Glu Arg Gly Ser Phe Tyr 
465                 470                 475                 480 


Pro Gly Ser Gly Phe Ala Phe Tyr Ser Leu Asp Tyr Met Arg Thr Pro 
                485                 490                 495     


Leu Asp Val Gly Thr Glu Ser Thr Trp Glu Val Glu Val Val Ala His 
            500                 505                 510         


Ile Arg Pro Ala Ala Asp Thr Gly Val Leu Phe Ala Leu Trp Ala Pro 
        515                 520                 525             


Asp Leu Arg Ala Val Pro Leu Ser Val Ala Leu Val Asp Tyr His Ser 
    530                 535                 540                 


Thr Lys Lys Leu Lys Lys Gln Leu Val Val Leu Ala Val Glu His Thr 
545                 550                 555                 560 


Ala Leu Ala Leu Met Glu Ile Lys Val Cys Asp Gly Gln Glu His Val 
                565                 570                 575     


Val Thr Val Ser Leu Arg Asp Gly Glu Ala Thr Leu Glu Val Asp Gly 
            580                 585                 590         


Thr Arg Gly Gln Ser Glu Val Ser Ala Ala Gln Leu Gln Glu Arg Leu 
        595                 600                 605             


Ala Val Leu Glu Arg His Leu Arg Ser Pro Val Leu Thr Phe Ala Gly 
    610                 615                 620                 


Gly Leu Pro Asp Val Pro Val Thr Ser Ala Pro Val Thr Ala Phe Tyr 
625                 630                 635                 640 


Arg Gly Cys Met Thr Leu Glu Val Asn Arg Arg Leu Leu Asp Leu Asp 
                645                 650                 655     


Glu Ala Ala Tyr Lys His Ser Asp Ile Thr Ala His Ser Cys Pro Pro 
            660                 665                 670         


Val Glu Pro Ala Ala Ala 
        675             


<210>  5801
<211>  101
<212>  PRT
<213>  Homo Sapiens

<400>  5801

Met Gln Arg Leu Cys Val Tyr Val Leu Ile Phe Ala Leu Ala Leu Ala 
1               5                   10                  15      


Ala Phe Ser Glu Ala Ser Trp Lys Pro Arg Ser Gln Gln Pro Asp Ala 
            20                  25                  30          


Pro Leu Gly Thr Gly Ala Asn Arg Asp Leu Glu Leu Pro Trp Leu Glu 
        35                  40                  45              


Gln Gln Gly Pro Ala Ser His His Arg Arg Gln Leu Gly Pro Gln Gly 
    50                  55                  60                  


Pro Pro His Leu Val Ala Asp Pro Ser Lys Lys Gln Gly Pro Trp Leu 
65                  70                  75                  80  


Glu Glu Glu Glu Glu Ala Tyr Gly Trp Met Asp Phe Gly Arg Arg Ser 
                85                  90                  95      


Ala Glu Asp Glu Asn 
            100     


<210>  5802
<211>  144
<212>  PRT
<213>  Homo Sapiens

<400>  5802

Lys Leu Glu Ser Ile Asp Gly Ala Arg Tyr His Ala Leu Leu Ile Pro 
1               5                   10                  15      


Ser Cys Pro Gly Ala Leu Thr Asp Leu Ala Ser Ser Gly Ser Leu Ala 
            20                  25                  30          


Arg Ile Leu Gln His Phe His Ser Glu Ser Lys Pro Ile Cys Ala Val 
        35                  40                  45              


Gly His Gly Val Ala Ala Leu Cys Cys Ala Thr Asn Glu Asp Arg Ser 
    50                  55                  60                  


Trp Val Phe Asp Ser Tyr Ser Leu Thr Gly Pro Ser Val Cys Glu Leu 
65                  70                  75                  80  


Val Arg Ala Pro Gly Phe Ala Arg Leu Pro Leu Val Val Glu Asp Phe 
                85                  90                  95      


Val Lys Asp Ser Gly Ala Cys Phe Ser Gly Leu Gly Ala Ala Pro Gly 
            100                 105                 110         


Trp Gly Arg Gly Gly Lys Gln Glu Asp Arg Pro Pro Glu Glu Gln Arg 
        115                 120                 125             


Arg Ala Gly Glu Asp Phe Pro Ile Tyr Gln Cys Val Phe Ile Tyr Pro 
    130                 135                 140                 


<210>  5803
<211>  184
<212>  PRT
<213>  Homo Sapiens

<400>  5803

Met Ala Ser Glu Arg Leu Pro Asn Arg Pro Ala Cys Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Ala Ala Glu Gly Val Ser Ala Gln Ser Phe Leu His Cys Phe 
            20                  25                  30          


Thr Met Ala Ser Thr Ala Phe Asn Leu Gln Val Ala Thr Pro Gly Gly 
        35                  40                  45              


Lys Ala Met Glu Phe Val Asp Val Thr Glu Ser Asn Ala Arg Trp Val 
    50                  55                  60                  


Gln Asp Phe Arg Leu Lys Ala Tyr Ala Ser Pro Ala Lys Leu Glu Ser 
65                  70                  75                  80  


Ile Asp Glu Pro Ile Cys Ala Val Gly His Gly Val Ala Ala Leu Cys 
                85                  90                  95      


Cys Ala Thr Asn Glu Asp Arg Ser Trp Val Phe Asp Ser Tyr Ser Leu 
            100                 105                 110         


Thr Gly Pro Ser Val Cys Glu Leu Val Arg Ala Pro Gly Phe Ala Arg 
        115                 120                 125             


Leu Pro Leu Val Val Glu Asp Phe Val Lys Asp Ser Gly Ala Cys Phe 
    130                 135                 140                 


Ser Ala Ser Glu Pro Asp Ala Val His Val Val Leu Asp Arg His Leu 
145                 150                 155                 160 


Val Thr Gly Gln Asn Ala Ser Ser Thr Val Pro Ala Val Gln Asn Leu 
                165                 170                 175     


Leu Phe Leu Cys Gly Ser Arg Lys 
            180                 


<210>  5804
<211>  184
<212>  PRT
<213>  Homo Sapiens

<400>  5804

Met Ala Ser Glu Arg Leu Pro Asn Arg Pro Ala Cys Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Ala Ala Glu Gly Val Ser Ala Gln Ser Phe Leu His Cys Phe 
            20                  25                  30          


Thr Met Ala Ser Thr Ala Phe Asn Leu Gln Val Ala Thr Pro Gly Gly 
        35                  40                  45              


Lys Ala Met Glu Phe Val Asp Val Thr Glu Ser Asn Ala Arg Trp Val 
    50                  55                  60                  


Gln Asp Phe Arg Leu Lys Ala Tyr Ala Ser Pro Ala Lys Leu Glu Ser 
65                  70                  75                  80  


Ile Asp Glu Pro Ile Cys Ala Val Gly His Gly Val Ala Ala Leu Cys 
                85                  90                  95      


Cys Ala Thr Asn Glu Asp Arg Ser Trp Val Phe Asp Ser Tyr Ser Leu 
            100                 105                 110         


Thr Gly Pro Ser Val Cys Glu Leu Val Arg Ala Pro Gly Phe Ala Arg 
        115                 120                 125             


Leu Pro Leu Val Val Glu Asp Phe Val Lys Asp Ser Gly Ala Cys Phe 
    130                 135                 140                 


Ser Ala Ser Glu Pro Asp Ala Val His Val Val Leu Asp Arg His Leu 
145                 150                 155                 160 


Val Thr Gly Gln Asn Ala Ser Ser Thr Val Pro Ala Val Gln Asn Leu 
                165                 170                 175     


Leu Phe Leu Cys Gly Ser Arg Lys 
            180                 


<210>  5805
<211>  186
<212>  PRT
<213>  Homo Sapiens

<400>  5805

Met Ala Ser Glu Arg Leu Pro Asn Arg Pro Ala Cys Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Ala Ala Glu Gly Val Ser Ala Gln Ser Phe Leu His Cys Phe 
            20                  25                  30          


Thr Met Ala Ser Thr Ala Phe Asn Leu Gln Val Ala Thr Pro Gly Gly 
        35                  40                  45              


Lys Ala Met Glu Phe Val Asp Val Thr Glu Ser Asn Ala Arg Trp Val 
    50                  55                  60                  


Gln Asp Phe Arg Leu Lys Ala Tyr Ala Ser Pro Ala Lys Leu Glu Ser 
65                  70                  75                  80  


Ile Asp Gly Ala Arg Tyr His Ala Leu Leu Ile Pro Ser Cys Pro Gly 
                85                  90                  95      


Ala Leu Thr Asp Leu Ala Ser Ser Gly Ser Leu Ala Arg Ile Leu Gln 
            100                 105                 110         


His Phe His Ser Glu Ser Lys Pro Ile Cys Ala Val Gly His Gly Val 
        115                 120                 125             


Ala Ala Leu Cys Cys Ala Thr Asn Glu Asp Arg Ser Trp Val Phe Asp 
    130                 135                 140                 


Ser Tyr Ser Leu Thr Gly Gly Leu Gly Leu Ser Gln Glu Pro Pro Pro 
145                 150                 155                 160 


Arg Ser Arg Ser Pro Leu Cys Val Ser Ser Ser Gly Pro Pro Ala Ser 
                165                 170                 175     


Pro Ala Cys Arg Ser Trp Trp Arg Thr Ser 
            180                 185     


<210>  5806
<211>  220
<212>  PRT
<213>  Homo Sapiens

<400>  5806

Met Ala Ser Glu Arg Leu Pro Asn Arg Pro Ala Cys Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Ala Ala Glu Gly Val Ser Ala Gln Ser Phe Leu His Cys Phe 
            20                  25                  30          


Thr Met Ala Ser Thr Ala Phe Asn Leu Gln Val Ala Thr Pro Gly Gly 
        35                  40                  45              


Lys Ala Met Glu Phe Val Asp Val Thr Glu Ser Asn Ala Arg Trp Val 
    50                  55                  60                  


Gln Asp Phe Arg Leu Lys Ala Tyr Ala Ser Pro Ala Lys Leu Glu Ser 
65                  70                  75                  80  


Ile Asp Gly Ala Arg Tyr His Ala Leu Leu Ile Pro Ser Cys Pro Gly 
                85                  90                  95      


Ala Leu Thr Asp Leu Ala Ser Ser Gly Ser Leu Ala Arg Ile Leu Gln 
            100                 105                 110         


His Phe His Ser Glu Ser Lys Pro Ile Cys Ala Val Gly His Gly Val 
        115                 120                 125             


Ala Ala Leu Cys Cys Ala Thr Asn Glu Asp Arg Ser Trp Val Phe Asp 
    130                 135                 140                 


Ser Tyr Ser Leu Thr Gly Pro Ser Val Cys Glu Leu Val Arg Ala Pro 
145                 150                 155                 160 


Gly Phe Ala Arg Leu Pro Leu Val Val Glu Asp Phe Val Lys Asp Ser 
                165                 170                 175     


Gly Ala Cys Phe Ser Ala Ser Glu Pro Asp Ala Val His Val Val Leu 
            180                 185                 190         


Asp Arg His Leu Val Thr Gly Gln Asn Ala Ser Ser Thr Val Pro Ala 
        195                 200                 205             


Val Gln Asn Leu Leu Phe Leu Cys Gly Ser Arg Lys 
    210                 215                 220 


<210>  5807
<211>  250
<212>  PRT
<213>  Homo Sapiens

<400>  5807

Met Ala Ser Glu Arg Leu Pro Asn Arg Pro Ala Cys Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Ala Ala Glu Gly Val Ser Ala Gln Ser Phe Leu His Cys Phe 
            20                  25                  30          


Thr Met Ala Ser Thr Ala Phe Asn Leu Gln Val Ala Thr Pro Gly Gly 
        35                  40                  45              


Lys Ala Met Glu Phe Val Asp Val Thr Glu Ser Asn Ala Arg Trp Val 
    50                  55                  60                  


Gln Asp Phe Arg Leu Lys Ala Tyr Ala Ser Pro Ala Lys Leu Glu Ser 
65                  70                  75                  80  


Ile Asp Gly Ala Arg Tyr His Ala Leu Leu Ile Pro Ser Cys Pro Gly 
                85                  90                  95      


Ala Leu Thr Asp Leu Ala Ser Ser Gly Ser Leu Ala Arg Ile Leu Gln 
            100                 105                 110         


His Phe His Ser Glu Ser Lys Pro Ile Cys Ala Val Gly His Gly Val 
        115                 120                 125             


Ala Ala Leu Cys Cys Ala Thr Asn Glu Asp Arg Ser Trp Val Phe Asp 
    130                 135                 140                 


Ser Tyr Ser Leu Thr Gly Pro Ser Val Cys Glu Leu Val Arg Ala Pro 
145                 150                 155                 160 


Gly Phe Ala Arg Leu Pro Leu Val Val Glu Asp Phe Val Lys Asp Ser 
                165                 170                 175     


Gly Ala Cys Phe Ser Gly Ala Ala Ala Ser Cys Pro Lys Ala Asp Arg 
            180                 185                 190         


His Trp Gln His Phe Pro Val Glu Glu Ile Phe Leu Ala Cys Gly Phe 
        195                 200                 205             


Lys Val Ala Gly Leu Gly Ala Ala Pro Gly Trp Gly Arg Gly Gly Lys 
    210                 215                 220                 


Gln Glu Asp Arg Pro Pro Glu Glu Gln Arg Arg Ala Gly Glu Asp Phe 
225                 230                 235                 240 


Pro Ile Tyr Gln Cys Val Phe Ile Tyr Pro 
                245                 250 


<210>  5808
<211>  120
<212>  PRT
<213>  Homo Sapiens

<400>  5808

Met Ala Ser Glu Arg Leu Pro Asn Arg Pro Ala Cys Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Ala Ala Glu Gly Val Ser Ala Gln Ser Phe Leu His Cys Phe 
            20                  25                  30          


Thr Met Ala Ser Thr Ala Phe Asn Leu Gln Val Ala Thr Pro Gly Gly 
        35                  40                  45              


Lys Ala Met Glu Phe Val Asp Val Thr Glu Ser Asn Ala Arg Trp Val 
    50                  55                  60                  


Gln Asp Phe Arg Leu Lys Ala Tyr Ala Ser Pro Ala Lys Leu Glu Ser 
65                  70                  75                  80  


Ile Asp Gly Ala Arg Tyr His Ala Leu Leu Ile Pro Ser Cys Pro Gly 
                85                  90                  95      


Ala Leu Thr Asp Leu Ala Ser Ser Gly Ser Leu Ala Arg Ile Leu Gln 
            100                 105                 110         


His Phe His Ser Glu Ser Ser Arg 
        115                 120 


<210>  5809
<211>  162
<212>  PRT
<213>  Homo Sapiens

<400>  5809

Trp Val Gln Asp Phe Arg Leu Lys Ala Tyr Ala Ser Pro Ala Lys Leu 
1               5                   10                  15      


Glu Ser Ile Asp Gly Ala Arg Tyr His Ala Leu Leu Ile Pro Ser Cys 
            20                  25                  30          


Pro Gly Ala Leu Thr Asp Leu Ala Ser Ser Gly Ser Leu Ala Arg Ile 
        35                  40                  45              


Leu Gln His Phe His Ser Glu Ser Lys Pro Ile Cys Ala Val Gly His 
    50                  55                  60                  


Gly Val Ala Ala Leu Cys Cys Ala Thr Asn Glu Asp Arg Ser Trp Val 
65                  70                  75                  80  


Phe Asp Ser Tyr Ser Leu Thr Gly Pro Ser Val Cys Glu Leu Val Arg 
                85                  90                  95      


Ala Pro Gly Phe Ala Arg Leu Pro Leu Val Val Glu Asp Phe Val Lys 
            100                 105                 110         


Asp Ser Gly Ala Cys Phe Ser Gly Gln Gly Leu Gly Gln His Gln Ala 
        115                 120                 125             


Gly Ala Glu Glu Glu Ser Lys Arg Thr Asp Leu Gln Lys Ser Ser Gly 
    130                 135                 140                 


Gly Arg Val Arg Ile Ser Pro Tyr Thr Ser Val Cys Ser Ser Thr His 
145                 150                 155                 160 


Glu Glu 
        


<210>  5810
<211>  87
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5810

Xaa Pro Ser Val Cys Glu Leu Val Arg Ala Pro Gly Phe Ala Arg Leu 
1               5                   10                  15      


Pro Leu Val Val Glu Asp Phe Val Lys Asp Ser Gly Ala Cys Phe Ser 
            20                  25                  30          


Ala Ser Glu Pro Asp Ala Val His Val Val Leu Asp Arg His Leu Val 
        35                  40                  45              


Thr Gly Gln Asn Ala Ser Ser Thr Val Pro Ala Val Gln Asn Leu Leu 
    50                  55                  60                  


Phe Leu Cys Gly Ser Arg Ser Ser Ser Leu Leu Pro Gln Gly Arg Pro 
65                  70                  75                  80  


Ala Leu Ala Ala Leu Ser Cys 
                85          


<210>  5811
<211>  487
<212>  PRT
<213>  Homo Sapiens

<400>  5811

Met Glu Phe Ser Ser Pro Ser Arg Glu Glu Cys Pro Lys Pro Leu Ser 
1               5                   10                  15      


Arg Val Ser Ile Met Ala Gly Ser Leu Thr Gly Leu Leu Leu Leu Gln 
            20                  25                  30          


Ala Val Ser Trp Ala Ser Gly Ala Arg Pro Cys Ile Pro Lys Ser Phe 
        35                  40                  45              


Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala Thr Tyr Cys Asp Ser 
    50                  55                  60                  


Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr Phe Ser Arg Tyr Glu 
65                  70                  75                  80  


Ser Thr Arg Ser Gly Arg Arg Met Glu Leu Ser Met Gly Pro Ile Gln 
                85                  90                  95      


Ala Asn His Thr Gly Thr Gly Ile Gly Tyr Asn Ile Ile Arg Val Pro 
            100                 105                 110         


Met Ala Ser Cys Asp Phe Ser Ile Arg Thr Tyr Thr Tyr Ala Asp Thr 
        115                 120                 125             


Pro Asp Asp Phe Gln Leu His Asn Phe Ser Leu Pro Glu Glu Asp Thr 
    130                 135                 140                 


Lys Leu Lys Ile Pro Leu Ile His Arg Ala Leu Gln Leu Ala Gln Arg 
145                 150                 155                 160 


Pro Val Ser Leu Leu Ala Ser Pro Trp Thr Ser Pro Thr Trp Leu Lys 
                165                 170                 175     


Thr Asn Gly Ala Val Asn Gly Lys Gly Ser Leu Lys Gly Gln Pro Gly 
            180                 185                 190         


Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe Val Lys Phe Leu Asp 
        195                 200                 205             


Ala Tyr Ala Glu His Lys Leu Gln Phe Trp Ala Val Thr Ala Glu Asn 
    210                 215                 220                 


Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro Phe Gln Cys Leu Gly 
225                 230                 235                 240 


Phe Thr Pro Glu His Gln Arg Asp Phe Ile Ala Arg Asp Leu Gly Pro 
                245                 250                 255     


Thr Leu Ala Asn Ser Thr His His Asn Val Arg Leu Leu Met Leu Asp 
            260                 265                 270         


Asp Gln Arg Leu Leu Leu Pro His Trp Ala Lys Val Val Leu Thr Asp 
        275                 280                 285             


Pro Glu Ala Ala Lys Tyr Val His Gly Ile Ala Val His Trp Tyr Leu 
    290                 295                 300                 


Asp Phe Leu Ala Pro Ala Lys Ala Thr Leu Gly Glu Thr His Arg Leu 
305                 310                 315                 320 


Phe Pro Asn Thr Met Leu Phe Ala Ser Glu Ala Cys Val Gly Ser Lys 
                325                 330                 335     


Phe Trp Glu Gln Ser Val Arg Leu Gly Ser Trp Asp Arg Gly Met Gln 
            340                 345                 350         


Tyr Ser His Ser Ile Ile Thr Asn Leu Leu Tyr His Val Val Gly Trp 
        355                 360                 365             


Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly Gly Pro Asn Trp Val 
    370                 375                 380                 


Arg Asn Phe Val Asp Ser Pro Ile Ile Val Asp Ile Thr Lys Asp Thr 
385                 390                 395                 400 


Phe Tyr Lys Gln Pro Met Phe Tyr His Leu Gly His Phe Ser Lys Phe 
                405                 410                 415     


Ile Pro Glu Gly Ser Gln Arg Val Gly Leu Val Ala Ser Gln Lys Asn 
            420                 425                 430         


Asp Leu Asp Ala Val Ala Leu Met His Pro Asp Gly Ser Ala Val Val 
        435                 440                 445             


Val Val Leu Asn Arg Ser Ser Lys Asp Val Pro Leu Thr Ile Lys Asp 
    450                 455                 460                 


Pro Ala Val Gly Phe Leu Glu Thr Ile Ser Pro Gly Tyr Ser Ile His 
465                 470                 475                 480 


Thr Tyr Leu Trp Arg Arg Gln 
                485         


<210>  5812
<211>  536
<212>  PRT
<213>  Homo Sapiens

<400>  5812

Met Glu Phe Ser Ser Pro Ser Arg Glu Glu Cys Pro Lys Pro Leu Ser 
1               5                   10                  15      


Arg Val Ser Ile Met Ala Gly Ser Leu Thr Gly Leu Leu Leu Leu Gln 
            20                  25                  30          


Ala Val Ser Trp Ala Ser Gly Ala Arg Pro Cys Ile Pro Lys Ser Phe 
        35                  40                  45              


Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala Thr Tyr Cys Asp Ser 
    50                  55                  60                  


Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr Phe Ser Arg Tyr Glu 
65                  70                  75                  80  


Ser Thr Arg Ser Gly Arg Arg Met Glu Leu Ser Met Gly Pro Ile Gln 
                85                  90                  95      


Ala Asn His Thr Gly Thr Gly Leu Leu Leu Thr Leu Gln Pro Glu Gln 
            100                 105                 110         


Lys Phe Gln Lys Val Lys Gly Phe Gly Gly Ala Met Thr Asp Ala Ala 
        115                 120                 125             


Ala Leu Asn Ile Leu Ala Leu Ser Pro Pro Ala Gln Asn Leu Leu Leu 
    130                 135                 140                 


Lys Ser Tyr Phe Ser Glu Glu Gly Ile Gly Tyr Asn Ile Ile Arg Val 
145                 150                 155                 160 


Pro Met Ala Ser Cys Asp Phe Ser Ile Arg Thr Tyr Thr Tyr Ala Asp 
                165                 170                 175     


Thr Pro Asp Asp Phe Gln Leu His Asn Phe Ser Leu Pro Glu Glu Asp 
            180                 185                 190         


Thr Lys Leu Lys Ile Pro Leu Ile His Arg Ala Leu Gln Leu Ala Gln 
        195                 200                 205             


Arg Pro Val Ser Leu Leu Ala Ser Pro Trp Thr Ser Pro Thr Trp Leu 
    210                 215                 220                 


Lys Thr Asn Gly Ala Val Asn Gly Lys Gly Ser Leu Lys Gly Gln Pro 
225                 230                 235                 240 


Gly Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe Val Lys Phe Leu 
                245                 250                 255     


Asp Ala Tyr Ala Glu His Lys Leu Gln Phe Trp Ala Val Thr Ala Glu 
            260                 265                 270         


Asn Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro Phe Gln Cys Leu 
        275                 280                 285             


Gly Phe Thr Pro Glu His Gln Arg Asp Phe Ile Ala Arg Asp Leu Gly 
    290                 295                 300                 


Pro Thr Leu Ala Asn Ser Thr His His Asn Val Arg Leu Leu Met Leu 
305                 310                 315                 320 


Asp Asp Gln Arg Leu Leu Leu Pro His Trp Ala Lys Val Val Leu Thr 
                325                 330                 335     


Asp Pro Glu Ala Ala Lys Tyr Val His Gly Ile Ala Val His Trp Tyr 
            340                 345                 350         


Leu Asp Phe Leu Ala Pro Ala Lys Ala Thr Leu Gly Glu Thr His Arg 
        355                 360                 365             


Leu Phe Pro Asn Thr Met Leu Phe Ala Ser Glu Ala Cys Val Gly Ser 
    370                 375                 380                 


Lys Phe Trp Glu Gln Ser Val Arg Leu Gly Ser Trp Asp Arg Gly Met 
385                 390                 395                 400 


Gln Tyr Ser His Ser Ile Ile Thr Asn Leu Leu Tyr His Val Val Gly 
                405                 410                 415     


Trp Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly Gly Pro Asn Trp 
            420                 425                 430         


Val Arg Asn Phe Val Asp Ser Pro Ile Ile Val Asp Ile Thr Lys Asp 
        435                 440                 445             


Thr Phe Tyr Lys Gln Pro Met Phe Tyr His Leu Gly His Phe Ser Lys 
    450                 455                 460                 


Phe Ile Pro Glu Gly Ser Gln Arg Val Gly Leu Val Ala Ser Gln Lys 
465                 470                 475                 480 


Asn Asp Leu Asp Ala Val Ala Leu Met His Pro Asp Gly Ser Ala Val 
                485                 490                 495     


Val Val Val Leu Asn Arg Ser Ser Lys Asp Val Pro Leu Thr Ile Lys 
            500                 505                 510         


Asp Pro Ala Val Gly Phe Leu Glu Thr Ile Ser Pro Gly Tyr Ser Ile 
        515                 520                 525             


His Thr Tyr Leu Trp Arg Arg Gln 
    530                 535     


<210>  5813
<211>  536
<212>  PRT
<213>  Homo Sapiens

<400>  5813

Met Glu Phe Ser Ser Pro Ser Arg Glu Glu Cys Pro Lys Pro Leu Ser 
1               5                   10                  15      


Arg Val Ser Ile Met Ala Gly Ser Leu Thr Gly Leu Leu Leu Leu Gln 
            20                  25                  30          


Ala Val Ser Trp Ala Ser Gly Ala Arg Pro Cys Ile Pro Lys Ser Phe 
        35                  40                  45              


Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala Thr Tyr Cys Asp Ser 
    50                  55                  60                  


Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr Phe Ser Arg Tyr Glu 
65                  70                  75                  80  


Ser Thr Arg Ser Gly Arg Arg Met Glu Leu Ser Met Gly Pro Ile Gln 
                85                  90                  95      


Ala Asn His Thr Gly Thr Gly Leu Leu Leu Thr Leu Gln Pro Glu Gln 
            100                 105                 110         


Lys Phe Gln Lys Val Lys Gly Phe Gly Gly Ala Met Thr Asp Ala Ala 
        115                 120                 125             


Ala Leu Asn Ile Leu Ala Leu Ser Pro Pro Ala Gln Asn Leu Leu Leu 
    130                 135                 140                 


Lys Ser Tyr Phe Ser Glu Glu Gly Ile Gly Tyr Asn Ile Ile Arg Val 
145                 150                 155                 160 


Pro Met Ala Ser Cys Asp Phe Ser Ile Arg Thr Tyr Thr Tyr Ala Asp 
                165                 170                 175     


Thr Pro Asp Asp Phe Gln Leu His Asn Phe Ser Leu Pro Glu Glu Asp 
            180                 185                 190         


Thr Lys Leu Lys Ile Pro Leu Ile His Arg Ala Leu Gln Leu Ala Gln 
        195                 200                 205             


Arg Pro Val Ser Leu Leu Ala Ser Pro Trp Thr Ser Pro Thr Trp Leu 
    210                 215                 220                 


Lys Thr Asn Gly Ala Val Asn Gly Lys Gly Ser Leu Lys Gly Gln Pro 
225                 230                 235                 240 


Gly Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe Val Lys Phe Leu 
                245                 250                 255     


Asp Ala Tyr Ala Glu His Lys Leu Gln Phe Trp Ala Val Thr Ala Glu 
            260                 265                 270         


Asn Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro Phe Gln Cys Leu 
        275                 280                 285             


Gly Phe Thr Pro Glu His Gln Arg Asp Phe Ile Ala Arg Asp Leu Gly 
    290                 295                 300                 


Pro Thr Leu Ala Asn Ser Thr His His Asn Val Arg Leu Leu Met Leu 
305                 310                 315                 320 


Asp Asp Gln Arg Leu Leu Leu Pro His Trp Ala Lys Val Val Leu Thr 
                325                 330                 335     


Asp Pro Glu Ala Ala Lys Tyr Val His Gly Ile Ala Val His Trp Tyr 
            340                 345                 350         


Leu Asp Phe Leu Ala Pro Ala Lys Ala Thr Leu Gly Glu Thr His Arg 
        355                 360                 365             


Leu Phe Pro Asn Thr Met Leu Phe Ala Ser Glu Ala Cys Val Gly Ser 
    370                 375                 380                 


Lys Phe Trp Glu Gln Ser Val Arg Leu Gly Ser Trp Asp Arg Gly Met 
385                 390                 395                 400 


Gln Tyr Ser His Ser Ile Ile Thr Asn Leu Leu Tyr His Val Val Gly 
                405                 410                 415     


Trp Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly Gly Pro Asn Trp 
            420                 425                 430         


Val Arg Asn Phe Val Asp Ser Pro Ile Ile Val Asp Ile Thr Lys Asp 
        435                 440                 445             


Thr Phe Tyr Lys Gln Pro Met Phe Tyr His Leu Gly His Phe Ser Lys 
    450                 455                 460                 


Phe Ile Pro Glu Gly Ser Gln Arg Val Gly Leu Val Ala Ser Gln Lys 
465                 470                 475                 480 


Asn Asp Leu Asp Ala Val Ala Leu Met His Pro Asp Gly Ser Ala Val 
                485                 490                 495     


Val Val Val Leu Asn Arg Ser Ser Lys Asp Val Pro Leu Thr Ile Lys 
            500                 505                 510         


Asp Pro Ala Val Gly Phe Leu Glu Thr Ile Ser Pro Gly Tyr Ser Ile 
        515                 520                 525             


His Thr Tyr Leu Trp Arg Arg Gln 
    530                 535     


<210>  5814
<211>  449
<212>  PRT
<213>  Homo Sapiens

<400>  5814

Met Glu Leu Ser Met Gly Pro Ile Gln Ala Asn His Thr Gly Thr Gly 
1               5                   10                  15      


Leu Leu Leu Thr Leu Gln Pro Glu Gln Lys Phe Gln Lys Val Lys Gly 
            20                  25                  30          


Phe Gly Gly Ala Met Thr Asp Ala Ala Ala Leu Asn Ile Leu Ala Leu 
        35                  40                  45              


Ser Pro Pro Ala Gln Asn Leu Leu Leu Lys Ser Tyr Phe Ser Glu Glu 
    50                  55                  60                  


Gly Ile Gly Tyr Asn Ile Ile Arg Val Pro Met Ala Ser Cys Asp Phe 
65                  70                  75                  80  


Ser Ile Arg Thr Tyr Thr Tyr Ala Asp Thr Pro Asp Asp Phe Gln Leu 
                85                  90                  95      


His Asn Phe Ser Leu Pro Glu Glu Asp Thr Lys Leu Lys Ile Pro Leu 
            100                 105                 110         


Ile His Arg Ala Leu Gln Leu Ala Gln Arg Pro Val Ser Leu Leu Ala 
        115                 120                 125             


Ser Pro Trp Thr Ser Pro Thr Trp Leu Lys Thr Asn Gly Ala Val Asn 
    130                 135                 140                 


Gly Lys Gly Ser Leu Lys Gly Gln Pro Gly Asp Ile Tyr His Gln Thr 
145                 150                 155                 160 


Trp Ala Arg Tyr Phe Val Lys Phe Leu Asp Ala Tyr Ala Glu His Lys 
                165                 170                 175     


Leu Gln Phe Trp Ala Val Thr Ala Glu Asn Glu Pro Ser Ala Gly Leu 
            180                 185                 190         


Leu Ser Gly Tyr Pro Phe Gln Cys Leu Gly Phe Thr Pro Glu His Gln 
        195                 200                 205             


Arg Asp Phe Ile Ala Arg Asp Leu Gly Pro Thr Leu Ala Asn Ser Thr 
    210                 215                 220                 


His His Asn Val Arg Leu Leu Met Leu Asp Asp Gln Arg Leu Leu Leu 
225                 230                 235                 240 


Pro His Trp Ala Lys Val Val Leu Thr Asp Pro Glu Ala Ala Lys Tyr 
                245                 250                 255     


Val His Gly Ile Ala Val His Trp Tyr Leu Asp Phe Leu Ala Pro Ala 
            260                 265                 270         


Lys Ala Thr Leu Gly Glu Thr His Arg Leu Phe Pro Asn Thr Met Leu 
        275                 280                 285             


Phe Ala Ser Glu Ala Cys Val Gly Ser Lys Phe Trp Glu Gln Ser Val 
    290                 295                 300                 


Arg Leu Gly Ser Trp Asp Arg Gly Met Gln Tyr Ser His Ser Ile Ile 
305                 310                 315                 320 


Thr Asn Leu Leu Tyr His Val Val Gly Trp Thr Asp Trp Asn Leu Ala 
                325                 330                 335     


Leu Asn Pro Glu Gly Gly Pro Asn Trp Val Arg Asn Phe Val Asp Ser 
            340                 345                 350         


Pro Ile Ile Val Asp Ile Thr Lys Asp Thr Phe Tyr Lys Gln Pro Met 
        355                 360                 365             


Phe Tyr His Leu Gly His Phe Ser Lys Phe Ile Pro Glu Gly Ser Gln 
    370                 375                 380                 


Arg Val Gly Leu Val Ala Ser Gln Lys Asn Asp Leu Asp Ala Val Ala 
385                 390                 395                 400 


Leu Met His Pro Asp Gly Ser Ala Val Val Val Val Leu Asn Arg Ser 
                405                 410                 415     


Ser Lys Asp Val Pro Leu Thr Ile Lys Asp Pro Ala Val Gly Phe Leu 
            420                 425                 430         


Glu Thr Ile Ser Pro Gly Tyr Ser Ile His Thr Tyr Leu Trp Arg Arg 
        435                 440                 445             


Gln 
    


<210>  5815
<211>  54
<212>  PRT
<213>  Homo Sapiens

<400>  5815

Met His Arg Arg Arg Leu Ala Leu Gly Leu Gly Phe Cys Leu Leu Ala 
1               5                   10                  15      


Gly Thr Ser Leu Ser Val Leu Trp Val Tyr Leu Glu Asn Trp Leu Pro 
            20                  25                  30          


Val Ser Tyr Val Pro Tyr Tyr Leu Pro Cys Pro Glu Ile Phe Ile Leu 
        35                  40                  45              


Ala Ala Pro Cys Met Val 
    50                  


<210>  5816
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  5816

Met His Arg Arg Arg Leu Ala Leu Gly Leu Gly Phe Cys Leu Leu Ala 
1               5                   10                  15      


Gly Thr Ser Leu Ser Val Leu Trp Val Tyr Leu Glu Asn Trp Leu Pro 
            20                  25                  30          


Val Ser Tyr Val Pro Tyr Tyr Leu Pro Cys Pro Glu Ile Phe Asn Met 
        35                  40                  45              


Lys Leu His Tyr Lys Arg Glu Lys Pro Leu Gln Pro Val Val Trp Ser 
    50                  55                  60                  


Gln Tyr Pro Gln Pro Lys Leu Leu Glu His Arg Gly Gly Ser Gln Cys 
65                  70                  75                  80  


Pro Arg Pro Pro Cys Cys Gln Ala His Thr Ala Ala Asp Thr His Thr 
                85                  90                  95      


Leu Val Gly Ala His Arg Leu Arg Gly Asn Leu Gln Pro Arg Ala Ser 
            100                 105                 110         


Ala Ala His Leu Pro Ala Thr Glu Pro Asp His Trp Gly His Gly Val 
        115                 120                 125             


Cys Arg Gly Glu Val His Ser Phe His Pro Val Leu Pro Gly Val Ser 
    130                 135                 140                 


Arg Gly Val Leu His Ala Trp Val Pro Gly Ala Leu Leu His Leu His 
145                 150                 155                 160 


<210>  5817
<211>  120
<212>  PRT
<213>  Homo Sapiens

<400>  5817

Met His Arg Arg Arg Leu Ala Leu Gly Leu Gly Phe Cys Leu Leu Ala 
1               5                   10                  15      


Gly Thr Ser Leu Ser Val Leu Trp Val Tyr Leu Glu Asn Trp Leu Pro 
            20                  25                  30          


Val Ser Tyr Val Pro Tyr Tyr Leu Pro Cys Pro Glu Ile Phe Asn Met 
        35                  40                  45              


Lys Leu His Tyr Lys Arg Glu Lys Pro Leu Gln Pro Val Val Trp Ser 
    50                  55                  60                  


Gln Tyr Pro Gln Pro Lys Leu Leu Glu His Arg Pro Thr Gln Leu Leu 
65                  70                  75                  80  


Thr Leu Thr Pro Trp Leu Ala Pro Ile Val Ser Glu Gly Thr Phe Asn 
                85                  90                  95      


Pro Glu Leu Leu Gln His Ile Tyr Gln Pro Leu Asn Leu Thr Ile Gly 
            100                 105                 110         


Val Thr Val Phe Ala Val Gly Lys 
        115                 120 


<210>  5818
<211>  347
<212>  PRT
<213>  Homo Sapiens

<400>  5818

Met His Arg Arg Arg Leu Ala Leu Gly Leu Gly Phe Cys Leu Leu Ala 
1               5                   10                  15      


Gly Thr Ser Leu Ser Val Leu Trp Val Tyr Leu Glu Asn Trp Leu Pro 
            20                  25                  30          


Val Ser Tyr Val Pro Tyr Tyr Leu Pro Cys Pro Glu Ile Phe Asn Met 
        35                  40                  45              


Lys Leu His Tyr Lys Arg Glu Lys Pro Leu Gln Pro Val Val Trp Ser 
    50                  55                  60                  


Gln Tyr Pro Gln Pro Lys Leu Leu Glu His Arg Pro Thr Gln Leu Leu 
65                  70                  75                  80  


Thr Leu Thr Pro Trp Leu Ala Pro Ile Val Ser Glu Gly Thr Phe Asn 
                85                  90                  95      


Pro Glu Leu Leu Gln His Ile Tyr Gln Pro Leu Asn Leu Thr Ile Gly 
            100                 105                 110         


Val Thr Val Phe Ala Val Gly Lys Tyr Thr His Phe Ile Gln Ser Phe 
        115                 120                 125             


Leu Glu Ser Ala Glu Glu Phe Phe Met Arg Gly Tyr Arg Val His Tyr 
    130                 135                 140                 


Tyr Ile Phe Thr Asp Asn Pro Ala Ala Val Pro Gly Val Pro Leu Gly 
145                 150                 155                 160 


Pro His Arg Leu Leu Ser Ser Ile Pro Ile Gln Gly His Ser His Trp 
                165                 170                 175     


Glu Glu Thr Ser Met Arg Arg Met Glu Thr Ile Ser Gln His Ile Ala 
            180                 185                 190         


Lys Arg Ala His Arg Glu Val Asp Tyr Leu Phe Cys Leu Asp Val Asp 
        195                 200                 205             


Met Val Phe Arg Asn Pro Trp Gly Pro Glu Thr Leu Gly Asp Leu Val 
    210                 215                 220                 


Ala Ala Ile His Pro Ser Tyr Tyr Ala Val Pro Arg Gln Gln Phe Pro 
225                 230                 235                 240 


Tyr Glu Arg Arg Arg Val Ser Thr Ala Phe Val Ala Asp Ser Glu Gly 
                245                 250                 255     


Asp Phe Tyr Tyr Gly Gly Ala Val Phe Gly Gly Gln Val Ala Arg Val 
            260                 265                 270         


Tyr Glu Phe Thr Arg Gly Cys His Met Ala Ile Leu Ala Asp Lys Ala 
        275                 280                 285             


Asn Gly Ile Met Ala Ala Trp Arg Glu Glu Ser His Leu Asn Arg His 
    290                 295                 300                 


Phe Ile Ser Asn Lys Pro Ser Lys Val Leu Ser Pro Glu Tyr Leu Trp 
305                 310                 315                 320 


Asp Asp Arg Lys Pro Gln Pro Pro Ser Leu Lys Leu Ile Arg Phe Ser 
                325                 330                 335     


Thr Leu Asp Lys Asp Ile Ser Cys Leu Arg Ser 
            340                 345         


<210>  5819
<211>  294
<212>  PRT
<213>  Homo Sapiens

<400>  5819

Met His Arg Arg Arg Leu Ala Leu Gly Leu Gly Phe Cys Leu Leu Ala 
1               5                   10                  15      


Gly Thr Ser Leu Ser Val Leu Trp Val Tyr Leu Glu Asn Trp Leu Pro 
            20                  25                  30          


Val Ser Tyr Val Pro Tyr Tyr Leu Pro Cys Pro Glu Ile Phe Asn Met 
        35                  40                  45              


Lys Leu His Tyr Lys Arg Glu Lys Pro Leu Gln Pro Val Val Trp Ser 
    50                  55                  60                  


Gln Tyr Pro Gln Pro Lys Leu Leu Glu His Arg Pro Thr Gln Leu Leu 
65                  70                  75                  80  


Thr Leu Thr Pro Trp Leu Ala Pro Ile Val Ser Glu Gly Thr Phe Asn 
                85                  90                  95      


Pro Glu Leu Leu Gln His Ile Tyr Gln Pro Leu Asn Leu Thr Ile Gly 
            100                 105                 110         


Val Thr Val Phe Ala Val Gly Asn Pro Ser Trp Ser Gln Pro Arg Ser 
        115                 120                 125             


Ser Ser Cys Val Gly Thr Gly Cys Thr Thr Thr Ser Ser Leu Thr Thr 
    130                 135                 140                 


Leu Gln Pro Phe Pro Gly Ser Arg Trp Val Pro Thr Gly Phe Ser Ala 
145                 150                 155                 160 


Pro Ser Pro Ser Arg Val Thr Pro Thr Gly Arg Arg His Pro Cys Ala 
                165                 170                 175     


Gly Trp Arg Pro Ser Ala Ser Thr Leu Leu Arg Gly Leu Thr Gly Arg 
            180                 185                 190         


Trp Thr Thr Ser Ser Ala Leu Met Trp Thr Trp Cys Phe Gly Thr Arg 
        195                 200                 205             


Gly Ala Leu Arg Pro Trp Glu Thr Trp Trp Leu Pro Phe Thr Gln Ala 
    210                 215                 220                 


Thr Thr Pro Phe Pro Ala Ser Ser Ser Pro Met Ser Ala Gly Val Phe 
225                 230                 235                 240 


Pro Leu Pro Leu Trp Gln Thr Ala Lys Gly Thr Ser Ile Met Val Gly 
                245                 250                 255     


Gln Ser Ser Gly Gly Arg Trp Pro Gly Tyr Met Ser Leu Leu Gly Ala 
            260                 265                 270         


Ala Thr Trp Pro Ser Trp Arg Thr Arg Pro Met Ala Ser Trp Leu Pro 
        275                 280                 285             


Gly Gly Arg Lys Ala Thr 
    290                 


<210>  5820
<211>  72
<212>  PRT
<213>  Homo Sapiens

<400>  5820

Met His Arg Arg Arg Leu Ala Leu Gly Leu Gly Phe Cys Leu Leu Ala 
1               5                   10                  15      


Gly Thr Ser Leu Ser Val Leu Trp Val Tyr Leu Glu Asn Trp Leu Pro 
            20                  25                  30          


Val Ser Tyr Val Pro Tyr Tyr Leu Pro Cys Pro Glu Ile Leu Leu Glu 
        35                  40                  45              


Tyr Arg Gly Val Ile Ser Ala His Cys Asn Leu His Leu Pro Gly Ser 
    50                  55                  60                  


Ser Asn Cys His Ala Ser Ala Thr 
65                  70          


<210>  5821
<211>  72
<212>  PRT
<213>  Homo Sapiens

<400>  5821

Met His Arg Arg Arg Leu Ala Leu Gly Leu Gly Phe Cys Leu Leu Ala 
1               5                   10                  15      


Gly Thr Ser Leu Ser Val Leu Trp Val Tyr Leu Glu Asn Trp Leu Pro 
            20                  25                  30          


Val Ser Tyr Val Pro Tyr Tyr Leu Pro Cys Pro Glu Ile Leu Leu Glu 
        35                  40                  45              


Tyr Arg Gly Val Ile Ser Ala His Cys Asn Leu His Leu Pro Gly Ser 
    50                  55                  60                  


Ser Asn Cys His Ala Ser Ala Thr 
65                  70          


<210>  5822
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  5822

Met His Arg Arg Arg Leu Ala Leu Gly Leu Gly Phe Cys Leu Leu Ala 
1               5                   10                  15      


Gly Thr Ser Leu Ser Val Leu Trp Val Tyr Leu Glu Asn Trp Leu Pro 
            20                  25                  30          


Val Ser Tyr Val Pro Tyr Tyr Leu Pro Cys Pro Glu Ile Leu Pro Met 
        35                  40                  45              


Met Met Ala Leu Ser Cys Leu Cys His Gln Gln His Glu Ala Ala Leu 
    50                  55                  60                  


Gln Glu Gly Glu Ala Thr Pro Ala Arg Gly Met Val Thr Val Pro Ser 
65                  70                  75                  80  


Ala Gln Ala Ala Gly Ala Gln Ala His Thr Ala Ala Asp Thr His Thr 
                85                  90                  95      


Leu Val Gly Ala His Arg Leu Arg Gly Asn Leu Gln Pro Arg Ala Ser 
            100                 105                 110         


Ala Ala His Leu Pro Ala Thr Glu Pro Asp His Trp Gly His Gly Val 
        115                 120                 125             


Cys Arg Gly Glu Val His Ser Phe His Pro Val Leu Pro Gly Val Ser 
    130                 135                 140                 


Arg Gly Val Leu His Ala Trp Val Pro Gly Ala Leu Leu His Leu His 
145                 150                 155                 160 


<210>  5823
<211>  330
<212>  PRT
<213>  Homo Sapiens

<400>  5823

Met His Arg Arg Arg Leu Ala Leu Gly Leu Gly Phe Cys Leu Leu Ala 
1               5                   10                  15      


Gly Thr Ser Leu Ser Val Leu Trp Val Tyr Leu Glu Asn Trp Leu Pro 
            20                  25                  30          


Val Ser Tyr Val Pro Tyr Tyr Leu Pro Cys Pro Glu Ile Leu Ser Gln 
        35                  40                  45              


Tyr Pro Gln Pro Lys Leu Leu Glu His Arg Pro Thr Gln Leu Leu Thr 
    50                  55                  60                  


Leu Thr Pro Trp Leu Ala Pro Ile Val Ser Glu Gly Thr Phe Asn Pro 
65                  70                  75                  80  


Glu Leu Leu Gln His Ile Tyr Gln Pro Leu Asn Leu Thr Ile Gly Val 
                85                  90                  95      


Thr Val Phe Ala Val Gly Lys Tyr Thr His Phe Ile Gln Ser Phe Leu 
            100                 105                 110         


Glu Ser Ala Glu Glu Phe Phe Met Arg Gly Tyr Arg Val His Tyr Tyr 
        115                 120                 125             


Ile Phe Thr Asp Asn Pro Ala Ala Val Pro Gly Val Pro Leu Gly Pro 
    130                 135                 140                 


His Arg Leu Leu Ser Ser Ile Pro Ile Gln Gly His Ser His Trp Glu 
145                 150                 155                 160 


Glu Thr Ser Met Arg Arg Met Glu Thr Ile Ser Gln His Ile Ala Lys 
                165                 170                 175     


Arg Ala His Arg Glu Val Asp Tyr Leu Phe Cys Leu Asp Val Asp Met 
            180                 185                 190         


Val Phe Arg Asn Pro Trp Gly Pro Glu Thr Leu Gly Asp Leu Val Ala 
        195                 200                 205             


Ala Ile His Pro Ser Tyr Tyr Ala Val Pro Arg Gln Gln Phe Pro Tyr 
    210                 215                 220                 


Glu Arg Arg Arg Val Ser Thr Ala Phe Val Ala Asp Ser Glu Gly Asp 
225                 230                 235                 240 


Phe Tyr Tyr Gly Gly Ala Val Phe Gly Gly Gln Val Ala Arg Val Tyr 
                245                 250                 255     


Glu Phe Thr Arg Gly Cys His Met Ala Ile Leu Ala Asp Lys Ala Asn 
            260                 265                 270         


Gly Ile Met Ala Ala Trp Arg Glu Glu Ser His Leu Asn Arg His Phe 
        275                 280                 285             


Ile Ser Asn Lys Pro Ser Lys Val Leu Ser Pro Glu Tyr Leu Trp Asp 
    290                 295                 300                 


Asp Arg Lys Pro Gln Pro Pro Ser Leu Lys Leu Ile Arg Phe Ser Thr 
305                 310                 315                 320 


Leu Asp Lys Asp Ile Ser Cys Leu Arg Ser 
                325                 330 


<210>  5824
<211>  145
<212>  PRT
<213>  Homo Sapiens

<400>  5824

Met Lys Arg Val Leu Val Leu Leu Leu Ala Val Ala Phe Gly His Ala 
1               5                   10                  15      


Leu Glu Arg Gly Arg Asp Tyr Glu Lys Asn Lys Val Cys Lys Glu Phe 
            20                  25                  30          


Ser His Leu Gly Lys Glu Asp Phe Thr Ser Leu Ser Leu Val Leu Tyr 
        35                  40                  45              


Ser Arg Lys Phe Pro Ser Gly Thr Phe Glu Gln Val Ser Gln Leu Val 
    50                  55                  60                  


Lys Glu Val Val Ser Leu Thr Glu Ala Cys Cys Ala Glu Gly Ala Asp 
65                  70                  75                  80  


Pro Asp Cys Tyr Asp Thr Arg Thr Ser Ala Leu Ser Ala Lys Ser Cys 
                85                  90                  95      


Glu Ser Asn Ser Pro Phe Pro Val His Pro Gly Thr Ala Glu Cys Cys 
            100                 105                 110         


Thr Lys Glu Gly Leu Glu Arg Lys Leu Cys Met Ala Ala Leu Lys His 
        115                 120                 125             


Gln Pro Gln Glu Phe Pro Thr Tyr Val Glu Pro Thr Asn Asp Glu Ile 
    130                 135                 140                 


Cys 
145 


<210>  5825
<211>  474
<212>  PRT
<213>  Homo Sapiens

<400>  5825

Met Lys Arg Val Leu Val Leu Leu Leu Ala Val Ala Phe Gly His Ala 
1               5                   10                  15      


Leu Glu Arg Gly Arg Asp Tyr Glu Lys Asn Lys Val Cys Lys Glu Phe 
            20                  25                  30          


Ser His Leu Gly Lys Glu Asp Phe Thr Ser Leu Ser Leu Val Leu Tyr 
        35                  40                  45              


Ser Arg Lys Phe Pro Ser Gly Thr Phe Glu Gln Val Ser Gln Leu Val 
    50                  55                  60                  


Lys Glu Val Val Ser Leu Thr Glu Ala Cys Cys Ala Glu Gly Ala Asp 
65                  70                  75                  80  


Pro Asp Cys Tyr Asp Thr Arg Thr Ser Ala Leu Ser Ala Lys Ser Cys 
                85                  90                  95      


Glu Ser Asn Ser Pro Phe Pro Val His Pro Gly Thr Ala Glu Cys Cys 
            100                 105                 110         


Thr Lys Glu Gly Leu Glu Arg Lys Leu Cys Met Ala Ala Leu Lys His 
        115                 120                 125             


Gln Pro Gln Glu Phe Pro Thr Tyr Val Glu Pro Thr Asn Asp Glu Ile 
    130                 135                 140                 


Cys Glu Ala Phe Arg Lys Asp Pro Lys Glu Tyr Ala Asn Gln Phe Met 
145                 150                 155                 160 


Trp Glu Tyr Ser Thr Asn Tyr Gly Gln Ala Pro Leu Ser Leu Leu Val 
                165                 170                 175     


Ser Tyr Thr Lys Ser Tyr Leu Ser Met Val Gly Ser Cys Cys Thr Ser 
            180                 185                 190         


Ala Ser Pro Thr Val Cys Phe Leu Lys Glu Arg Leu Gln Leu Lys His 
        195                 200                 205             


Leu Ser Leu Leu Thr Thr Leu Ser Asn Arg Val Cys Ser Gln Tyr Ala 
    210                 215                 220                 


Ala Tyr Gly Glu Lys Lys Ser Arg Leu Ser Asn Leu Ile Lys Leu Ala 
225                 230                 235                 240 


Gln Lys Val Pro Thr Ala Asp Leu Glu Asp Val Leu Pro Leu Ala Glu 
                245                 250                 255     


Asp Ile Thr Asn Ile Leu Ser Lys Cys Cys Glu Ser Ala Ser Glu Asp 
            260                 265                 270         


Cys Met Ala Lys Glu Leu Pro Glu His Thr Val Lys Leu Cys Asp Asn 
        275                 280                 285             


Leu Ser Thr Lys Asn Ser Lys Phe Glu Asp Cys Cys Gln Glu Lys Thr 
    290                 295                 300                 


Ala Met Asp Val Phe Val Cys Thr Tyr Phe Met Pro Ala Ala Gln Leu 
305                 310                 315                 320 


Pro Glu Leu Pro Asp Val Glu Leu Pro Thr Asn Lys Asp Val Cys Asp 
                325                 330                 335     


Pro Gly Asn Thr Lys Val Met Asp Lys Tyr Thr Phe Glu Leu Ser Arg 
            340                 345                 350         


Arg Thr His Leu Pro Glu Val Phe Leu Ser Lys Val Leu Glu Pro Thr 
        355                 360                 365             


Leu Lys Ser Leu Gly Glu Cys Cys Asp Val Glu Asp Ser Thr Thr Cys 
    370                 375                 380                 


Phe Asn Ala Lys Gly Pro Leu Leu Lys Lys Glu Leu Ser Ser Phe Ile 
385                 390                 395                 400 


Asp Lys Gly Gln Glu Leu Cys Ala Asp Tyr Ser Glu Asn Thr Phe Thr 
                405                 410                 415     


Glu Tyr Lys Lys Lys Leu Ala Glu Arg Leu Lys Ala Lys Leu Pro Asp 
            420                 425                 430         


Ala Thr Pro Thr Glu Leu Ala Lys Leu Val Asn Lys His Ser Asp Phe 
        435                 440                 445             


Ala Ser Asn Cys Cys Ser Ile Asn Ser Pro Pro Leu Tyr Cys Asp Ser 
    450                 455                 460                 


Glu Ile Asp Ala Glu Leu Lys Asn Ile Leu 
465                 470                 


<210>  5826
<211>  348
<212>  PRT
<213>  Homo Sapiens

<400>  5826

Met Lys Arg Val Leu Val Leu Leu Leu Ala Val Ala Phe Gly His Ala 
1               5                   10                  15      


Leu Glu Arg Gly Arg Asp Tyr Glu Lys Asn Lys Val Cys Lys Glu Phe 
            20                  25                  30          


Ser His Leu Gly Lys Glu Asp Phe Thr Ser Leu Ser Leu Val Leu Tyr 
        35                  40                  45              


Ser Arg Lys Phe Pro Ser Gly Thr Phe Glu Gln Val Ser Gln Leu Val 
    50                  55                  60                  


Lys Glu Val Val Ser Leu Thr Glu Ala Cys Cys Ala Glu Gly Ala Asp 
65                  70                  75                  80  


Pro Asp Cys Tyr Asp Thr Arg Thr Ser Ala Leu Ser Ala Lys Ser Cys 
                85                  90                  95      


Glu Ser Asn Ser Pro Phe Pro Val His Pro Gly Thr Ala Glu Cys Cys 
            100                 105                 110         


Thr Lys Glu Gly Leu Glu Arg Lys Leu Cys Met Ala Ala Leu Lys His 
        115                 120                 125             


Gln Pro Gln Glu Phe Pro Thr Tyr Val Glu Pro Thr Asn Asp Glu Ile 
    130                 135                 140                 


Cys Glu Ala Phe Arg Lys Asp Pro Lys Glu Tyr Ala Asn Gln Phe Met 
145                 150                 155                 160 


Trp Glu Tyr Ser Thr Asn Tyr Gly Gln Ala Pro Leu Ser Leu Leu Val 
                165                 170                 175     


Ser Tyr Thr Lys Ser Tyr Leu Ser Met Val Gly Ser Cys Cys Thr Ser 
            180                 185                 190         


Ala Ser Pro Thr Val Cys Phe Leu Lys Glu Arg Leu Gln Leu Lys His 
        195                 200                 205             


Leu Ser Leu Leu Thr Thr Leu Ser Asn Arg Val Cys Ser Gln Tyr Ala 
    210                 215                 220                 


Ala Tyr Gly Glu Lys Lys Ser Arg Leu Ser Asn Leu Ile Lys Leu Ala 
225                 230                 235                 240 


Gln Lys Val Pro Thr Ala Asp Leu Glu Asp Val Leu Pro Leu Ala Glu 
                245                 250                 255     


Asp Ile Thr Asn Ile Leu Ser Lys Cys Cys Glu Ser Ala Ser Glu Asp 
            260                 265                 270         


Cys Met Ala Lys Glu Leu Pro Glu His Thr Val Lys Leu Cys Asp Asn 
        275                 280                 285             


Leu Ser Thr Lys Asn Ser Lys Phe Glu Asp Cys Cys Gln Glu Lys Thr 
    290                 295                 300                 


Ala Met Asp Val Phe Val Cys Thr Tyr Phe Met Pro Ala Ala Gln Leu 
305                 310                 315                 320 


Pro Glu Leu Pro Asp Val Glu Leu Pro Thr Asn Lys Asp Val Cys Asp 
                325                 330                 335     


Pro Gly Asn Thr Lys Val Met Asp Lys Ala Leu Tyr 
            340                 345             


<210>  5827
<211>  476
<212>  PRT
<213>  Homo Sapiens

<400>  5827

Met Lys Arg Val Leu Val Leu Leu Leu Ala Val Ala Phe Gly His Ala 
1               5                   10                  15      


Leu Glu Arg Gly Arg Asp Tyr Glu Lys Asn Lys Val Cys Lys Glu Phe 
            20                  25                  30          


Ser His Leu Gly Lys Glu Asp Phe Thr Ser Leu Ser Leu Val Leu Tyr 
        35                  40                  45              


Ser Arg Lys Phe Pro Ser Gly Thr Phe Glu Gln Val Ser Gln Leu Val 
    50                  55                  60                  


Lys Glu Val Val Ser Leu Thr Glu Ala Cys Cys Ala Glu Gly Ala Asp 
65                  70                  75                  80  


Pro Asp Cys Tyr Asp Thr Arg Thr Ser Ala Leu Ser Ala Lys Ser Cys 
                85                  90                  95      


Glu Ser Asn Ser Pro Phe Pro Val His Pro Gly Thr Ala Glu Cys Cys 
            100                 105                 110         


Thr Lys Glu Gly Leu Glu Arg Lys Leu Cys Met Ala Ala Leu Lys His 
        115                 120                 125             


Gln Pro Gln Glu Phe Pro Thr Tyr Val Glu Pro Thr Asn Asp Glu Ile 
    130                 135                 140                 


Cys Glu Ala Phe Arg Lys Asp Pro Lys Glu Tyr Ala Asn Gln Phe Met 
145                 150                 155                 160 


Trp Glu Tyr Ser Thr Asn Tyr Gly Gln Ala Pro Leu Ser Leu Leu Val 
                165                 170                 175     


Ser Tyr Thr Lys Ser Tyr Leu Ser Met Val Gly Ser Cys Cys Thr Ser 
            180                 185                 190         


Ala Ser Pro Thr Val Cys Phe Leu Lys Glu Arg Leu Gln Leu Lys His 
        195                 200                 205             


Leu Ser Leu Leu Thr Thr Leu Ser Asn Arg Val Cys Ser Gln Tyr Ala 
    210                 215                 220                 


Ala Tyr Gly Glu Lys Lys Ser Arg Leu Ser Asn Leu Ile Lys Leu Ala 
225                 230                 235                 240 


Gln Lys Val Pro Thr Ala Asp Leu Glu Asp Val Leu Pro Leu Ala Glu 
                245                 250                 255     


Asp Ile Thr Asn Ile Leu Ser Lys Cys Cys Glu Ser Ala Ser Glu Asp 
            260                 265                 270         


Cys Met Ala Lys Glu Leu Pro Glu His Thr Val Lys Leu Cys Asp Asn 
        275                 280                 285             


Leu Ser Thr Lys Asn Ser Lys Phe Glu Asp Cys Cys Gln Glu Lys Thr 
    290                 295                 300                 


Ala Met Asp Val Phe Val Cys Thr Tyr Phe Met Pro Ala Ala Gln Leu 
305                 310                 315                 320 


Pro Glu Leu Pro Asp Val Glu Leu Pro Thr Asn Lys Asp Val Cys Asp 
                325                 330                 335     


Pro Gly Asn Thr Lys Val Met Asp Lys Tyr Thr Phe Glu Leu Ser Arg 
            340                 345                 350         


Arg Thr His Leu Pro Glu Val Phe Leu Ser Lys Val Leu Glu Pro Thr 
        355                 360                 365             


Leu Lys Ser Leu Gly Glu Cys Cys Asp Val Glu Asp Ser Thr Thr Cys 
    370                 375                 380                 


Phe Asn Ala Lys Gly Pro Leu Leu Lys Lys Glu Leu Ser Ser Phe Ile 
385                 390                 395                 400 


Asp Lys Gly Gln Glu Leu Cys Ala Asp Tyr Ser Glu Asn Thr Phe Thr 
                405                 410                 415     


Glu Tyr Lys Lys Lys Leu Ala Glu Arg Leu Lys Ala Lys Leu Pro Asp 
            420                 425                 430         


Ala Thr Pro Thr Glu Leu Ala Lys Leu Val Asn Lys His Ser Asp Phe 
        435                 440                 445             


Ala Ser Asn Cys Cys Ser Ile Asn Ser Pro Pro Leu Tyr Cys Asp Ser 
    450                 455                 460                 


Glu Thr Arg Val Gly Ala Thr Gln Gly Asn Asp Leu 
465                 470                 475     


<210>  5828
<211>  493
<212>  PRT
<213>  Homo Sapiens

<400>  5828

Met Leu Trp Ser Trp Ser Glu Glu Arg Gly Gly Ala Ala Arg Leu Ser 
1               5                   10                  15      


Gly Arg Lys Met Lys Arg Val Leu Val Leu Leu Leu Ala Val Ala Phe 
            20                  25                  30          


Gly His Ala Leu Glu Arg Gly Arg Asp Tyr Glu Lys Asn Lys Val Cys 
        35                  40                  45              


Lys Glu Phe Ser His Leu Gly Lys Glu Asp Phe Thr Ser Leu Ser Leu 
    50                  55                  60                  


Val Leu Tyr Ser Arg Lys Phe Pro Ser Gly Thr Phe Glu Gln Val Ser 
65                  70                  75                  80  


Gln Leu Val Lys Glu Val Val Ser Leu Thr Glu Ala Cys Cys Ala Glu 
                85                  90                  95      


Gly Ala Asp Pro Asp Cys Tyr Asp Thr Arg Thr Ser Ala Leu Ser Ala 
            100                 105                 110         


Lys Ser Cys Glu Ser Asn Ser Pro Phe Pro Val His Pro Gly Thr Ala 
        115                 120                 125             


Glu Cys Cys Thr Lys Glu Gly Leu Glu Arg Lys Leu Cys Met Ala Ala 
    130                 135                 140                 


Leu Lys His Gln Pro Gln Glu Phe Pro Thr Tyr Val Glu Pro Thr Asn 
145                 150                 155                 160 


Asp Glu Ile Cys Glu Ala Phe Arg Lys Asp Pro Lys Glu Tyr Ala Asn 
                165                 170                 175     


Gln Phe Met Trp Glu Tyr Ser Thr Asn Tyr Gly Gln Ala Pro Leu Ser 
            180                 185                 190         


Leu Leu Val Ser Tyr Thr Lys Ser Tyr Leu Ser Met Val Gly Ser Cys 
        195                 200                 205             


Cys Thr Ser Ala Ser Pro Thr Val Cys Phe Leu Lys Glu Arg Leu Gln 
    210                 215                 220                 


Leu Lys His Leu Ser Leu Leu Thr Thr Leu Ser Asn Arg Val Cys Ser 
225                 230                 235                 240 


Gln Tyr Ala Ala Tyr Gly Glu Lys Lys Ser Arg Leu Ser Asn Leu Ile 
                245                 250                 255     


Lys Leu Ala Gln Lys Val Pro Thr Ala Asp Leu Glu Asp Val Leu Pro 
            260                 265                 270         


Leu Ala Glu Asp Ile Thr Asn Ile Leu Ser Lys Cys Cys Glu Ser Ala 
        275                 280                 285             


Ser Glu Asp Cys Met Ala Lys Glu Leu Pro Glu His Thr Val Lys Leu 
    290                 295                 300                 


Cys Asp Asn Leu Ser Thr Lys Asn Ser Lys Phe Glu Asp Cys Cys Gln 
305                 310                 315                 320 


Glu Lys Thr Ala Met Asp Val Phe Val Cys Thr Tyr Phe Met Pro Ala 
                325                 330                 335     


Ala Gln Leu Pro Glu Leu Pro Asp Val Glu Leu Pro Thr Asn Lys Asp 
            340                 345                 350         


Val Cys Asp Pro Gly Asn Thr Lys Val Met Asp Lys Tyr Thr Phe Glu 
        355                 360                 365             


Leu Ser Arg Arg Thr His Leu Pro Glu Val Phe Leu Ser Lys Val Leu 
    370                 375                 380                 


Glu Pro Thr Leu Lys Ser Leu Gly Glu Cys Cys Asp Val Glu Asp Ser 
385                 390                 395                 400 


Thr Thr Cys Phe Asn Ala Lys Gly Pro Leu Leu Lys Lys Glu Leu Ser 
                405                 410                 415     


Ser Phe Ile Asp Lys Gly Gln Glu Leu Cys Ala Asp Tyr Ser Glu Asn 
            420                 425                 430         


Thr Phe Thr Glu Tyr Lys Lys Lys Leu Ala Glu Arg Leu Lys Ala Lys 
        435                 440                 445             


Leu Pro Asp Ala Thr Pro Thr Glu Leu Ala Lys Leu Val Asn Lys His 
    450                 455                 460                 


Ser Asp Phe Ala Ser Asn Cys Cys Ser Ile Asn Ser Pro Pro Leu Tyr 
465                 470                 475                 480 


Cys Asp Ser Glu Ile Asp Ala Glu Leu Lys Asn Ile Leu 
                485                 490             


<210>  5829
<211>  180
<212>  PRT
<213>  Homo Sapiens

<400>  5829

Met Lys Ser Ile Tyr Phe Val Ala Gly Leu Phe Val Met Leu Val Gln 
1               5                   10                  15      


Gly Ser Trp Gln Arg Ser Leu Gln Asp Thr Glu Glu Lys Ser Arg Ser 
            20                  25                  30          


Phe Ser Ala Ser Gln Ala Asp Pro Leu Ser Asp Pro Asp Gln Met Asn 
        35                  40                  45              


Glu Asp Lys Arg His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys 
    50                  55                  60                  


Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn 
65                  70                  75                  80  


Thr Lys Arg Asn Arg Asn Asn Ile Ala Lys Arg His Asp Glu Phe Glu 
                85                  90                  95      


Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu 
            100                 105                 110         


Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
        115                 120                 125             


Arg Arg Asp Phe Pro Glu Glu Val Ala Ile Val Glu Glu Leu Gly Arg 
    130                 135                 140                 


Arg His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp 
145                 150                 155                 160 


Asn Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile 
                165                 170                 175     


Thr Asp Arg Lys 
            180 


<210>  5830
<211>  180
<212>  PRT
<213>  Homo Sapiens

<400>  5830

Met Lys Ser Ile Tyr Phe Val Ala Gly Leu Phe Val Met Leu Val Gln 
1               5                   10                  15      


Gly Ser Trp Gln Arg Ser Leu Gln Asp Thr Glu Glu Lys Ser Arg Ser 
            20                  25                  30          


Phe Ser Ala Ser Gln Ala Asp Pro Leu Ser Asp Pro Asp Gln Met Asn 
        35                  40                  45              


Glu Asp Lys Arg His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys 
    50                  55                  60                  


Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn 
65                  70                  75                  80  


Thr Lys Arg Asn Arg Asn Asn Ile Ala Lys Arg His Asp Glu Phe Glu 
                85                  90                  95      


Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu 
            100                 105                 110         


Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
        115                 120                 125             


Arg Arg Asp Phe Pro Glu Glu Val Ala Ile Val Glu Glu Leu Gly Arg 
    130                 135                 140                 


Arg His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp 
145                 150                 155                 160 


Asn Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile 
                165                 170                 175     


Thr Asp Arg Lys 
            180 


<210>  5831
<211>  80
<212>  PRT
<213>  Homo Sapiens

<400>  5831

Met Pro Pro Cys Gln Pro Gln Arg Pro Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ala Cys Gln Pro Gln Val Pro Ser Ala Gln Val Met Asp Phe Leu 
            20                  25                  30          


Phe Glu Lys Trp Lys Leu Tyr Gly Asp Gln Cys His His Asn Leu Ser 
        35                  40                  45              


Leu Leu Pro Pro Pro Thr Glu Leu Val Cys Asn Arg Thr Phe Asp Lys 
    50                  55                  60                  


Tyr Ser Cys Trp Pro Asp Thr Pro Ala Asn Thr Thr Ala Asn Ile Ser 
65                  70                  75                  80  


<210>  5832
<211>  477
<212>  PRT
<213>  Homo Sapiens

<400>  5832

Met Pro Pro Cys Gln Pro Gln Arg Pro Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ala Cys Gln Pro Gln Val Pro Ser Ala Gln Val Met Asp Phe Leu 
            20                  25                  30          


Phe Glu Lys Trp Lys Leu Tyr Gly Asp Gln Cys His His Asn Leu Ser 
        35                  40                  45              


Leu Leu Pro Pro Pro Thr Glu Leu Val Cys Asn Arg Thr Phe Asp Lys 
    50                  55                  60                  


Tyr Ser Cys Trp Pro Asp Thr Pro Ala Asn Thr Thr Ala Asn Ile Ser 
65                  70                  75                  80  


Cys Pro Trp Tyr Leu Pro Trp His His Lys Val Gln His Arg Phe Val 
                85                  90                  95      


Phe Lys Arg Cys Gly Pro Asp Gly Gln Trp Val Arg Gly Pro Arg Gly 
            100                 105                 110         


Gln Pro Trp Arg Asp Ala Ser Gln Cys Gln Met Asp Gly Glu Glu Ile 
        115                 120                 125             


Glu Val Gln Lys Glu Val Ala Lys Met Tyr Ser Ser Phe Gln Val Met 
    130                 135                 140                 


Tyr Thr Val Gly Tyr Ser Leu Ser Leu Gly Ala Leu Leu Leu Ala Leu 
145                 150                 155                 160 


Ala Ile Leu Gly Gly Leu Ser Lys Leu His Cys Thr Arg Asn Ala Ile 
                165                 170                 175     


His Ala Asn Leu Phe Ala Ser Phe Val Leu Lys Ala Ser Ser Val Leu 
            180                 185                 190         


Val Ile Asp Gly Leu Leu Arg Thr Arg Tyr Ser Gln Lys Ile Gly Asp 
        195                 200                 205             


Asp Leu Ser Val Ser Thr Trp Leu Ser Asp Gly Ala Val Ala Gly Cys 
    210                 215                 220                 


Arg Val Ala Ala Val Phe Met Gln Tyr Gly Ile Val Ala Asn Tyr Cys 
225                 230                 235                 240 


Trp Leu Leu Val Glu Gly Leu Tyr Leu His Asn Leu Leu Gly Leu Ala 
                245                 250                 255     


Thr Leu Pro Glu Arg Ser Phe Phe Ser Leu Tyr Leu Gly Ile Gly Trp 
            260                 265                 270         


Gly Ala Pro Met Leu Phe Val Val Pro Trp Ala Val Val Lys Cys Leu 
        275                 280                 285             


Phe Glu Asn Val Gln Cys Trp Thr Ser Asn Asp Asn Met Gly Phe Trp 
    290                 295                 300                 


Trp Ile Leu Arg Phe Pro Val Phe Leu Ala Ile Leu Ile Asn Phe Phe 
305                 310                 315                 320 


Ile Phe Val Arg Ile Val Gln Leu Leu Val Ala Lys Leu Arg Ala Arg 
                325                 330                 335     


Gln Met His His Thr Asp Tyr Lys Phe Arg Leu Ala Lys Ser Thr Leu 
            340                 345                 350         


Thr Leu Ile Pro Leu Leu Gly Val His Glu Val Val Phe Ala Phe Val 
        355                 360                 365             


Thr Asp Glu His Ala Gln Gly Thr Leu Arg Ser Ala Lys Leu Phe Phe 
    370                 375                 380                 


Asp Leu Phe Leu Ser Ser Phe Gln Gly Leu Leu Val Ala Val Leu Tyr 
385                 390                 395                 400 


Cys Phe Leu Asn Lys Glu Val Gln Ser Glu Leu Arg Arg Arg Trp His 
                405                 410                 415     


Arg Trp Arg Leu Gly Lys Val Leu Trp Glu Glu Arg Asn Thr Ser Asn 
            420                 425                 430         


His Arg Ala Ser Ser Ser Pro Gly His Gly Pro Pro Ser Lys Glu Leu 
        435                 440                 445             


Gln Phe Gly Arg Gly Gly Gly Ser Gln Asp Ser Ser Ala Glu Thr Pro 
    450                 455                 460                 


Leu Ala Gly Gly Leu Pro Arg Leu Ala Glu Ser Pro Phe 
465                 470                 475         


<210>  5833
<211>  523
<212>  PRT
<213>  Homo Sapiens

<400>  5833

Met Pro Pro Cys Gln Pro Gln Arg Pro Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ala Cys Gln Pro Gln Val Pro Ser Ala Gln Val Met Asp Phe Leu 
            20                  25                  30          


Phe Glu Lys Trp Lys Leu Tyr Gly Asp Gln Cys His His Asn Leu Ser 
        35                  40                  45              


Leu Leu Pro Pro Pro Thr Glu Leu Val Cys Asn Arg Thr Phe Asp Lys 
    50                  55                  60                  


Tyr Ser Cys Trp Pro Asp Thr Pro Ala Asn Thr Thr Ala Asn Ile Ser 
65                  70                  75                  80  


Cys Pro Trp Tyr Leu Pro Trp His His Lys Val Gln His Arg Phe Val 
                85                  90                  95      


Phe Lys Arg Cys Gly Pro Asp Gly Gln Trp Val Arg Gly Pro Arg Gly 
            100                 105                 110         


Gln Pro Trp Arg Asp Ala Ser Gln Cys Gln Met Asp Gly Glu Glu Ile 
        115                 120                 125             


Glu Val Gln Lys Glu Val Ala Lys Met Tyr Ser Ser Phe Gln Val Met 
    130                 135                 140                 


Tyr Thr Val Gly Tyr Ser Leu Ser Leu Gly Ala Leu Leu Leu Ala Leu 
145                 150                 155                 160 


Ala Ile Leu Gly Gly Leu Ser Lys Leu His Cys Thr Arg Asn Ala Ile 
                165                 170                 175     


His Ala Asn Leu Phe Ala Ser Phe Val Leu Lys Ala Ser Ser Val Leu 
            180                 185                 190         


Val Ile Asp Gly Leu Leu Arg Thr Arg Tyr Ser Gln Lys Ile Gly Asp 
        195                 200                 205             


Asp Leu Ser Val Ser Thr Trp Leu Ser Asp Gly Val Ser Pro Pro Arg 
    210                 215                 220                 


Arg Pro Gln Ala Gly Gly Trp Val Gly Ser Gln Ala Gly Gly His Val 
225                 230                 235                 240 


Ala Ala Leu Thr Leu His Leu Tyr Gln Ala Val Ala Gly Cys Arg Val 
                245                 250                 255     


Ala Ala Val Phe Met Gln Tyr Gly Ile Val Ala Asn Tyr Cys Trp Leu 
            260                 265                 270         


Leu Val Glu Gly Leu Tyr Leu His Asn Leu Leu Gly Leu Ala Thr Leu 
        275                 280                 285             


Pro Glu Arg Ser Phe Phe Ser Leu Tyr Leu Gly Ile Gly Trp Gly Ala 
    290                 295                 300                 


Pro Met Leu Phe Val Val Pro Trp Ala Val Val Lys Cys Leu Phe Glu 
305                 310                 315                 320 


Asn Val Gln Cys Trp Thr Ser Asn Asp Asn Met Gly Phe Trp Trp Ile 
                325                 330                 335     


Leu Arg Phe Pro Val Phe Leu Ala Ile Leu Ile Asn Phe Phe Ile Phe 
            340                 345                 350         


Val Arg Ile Val Gln Leu Leu Val Ala Lys Leu Arg Ala Arg Gln Met 
        355                 360                 365             


His His Thr Asp Tyr Lys Phe Arg Leu Ala Lys Ser Thr Leu Thr Leu 
    370                 375                 380                 


Ile Pro Leu Leu Gly Val His Glu Val Val Phe Ala Phe Val Thr Asp 
385                 390                 395                 400 


Glu His Ala Gln Gly Thr Leu Arg Ser Ala Lys Leu Phe Phe Asp Leu 
                405                 410                 415     


Phe Leu Ser Ser Phe Gln Val Pro Ala Arg Pro Pro Ala Pro Pro Pro 
            420                 425                 430         


Gly Ala Gln Cys Ala Thr Pro Asp His Pro Val Ser Pro Gly Pro Ala 
        435                 440                 445             


Gly Gly Cys Pro Leu Leu Leu Pro Gln Gln Gly Gly Ala Val Gly Ala 
    450                 455                 460                 


Ala Ala Ala Leu Ala Pro Leu Ala Pro Gly Gln Ser Ala Met Gly Gly 
465                 470                 475                 480 


Ala Glu His Gln Gln Pro Gln Gly Leu Ile Phe Ala Arg Pro Arg Pro 
                485                 490                 495     


Ser Gln Gln Gly Ala Ala Val Trp Glu Gly Trp Trp Gln Pro Gly Phe 
            500                 505                 510         


Ile Cys Gly Asp Pro Leu Gly Trp Trp Pro Pro 
        515                 520             


<210>  5834
<211>  308
<212>  PRT
<213>  Homo Sapiens

<400>  5834

Met Phe Val Gln Leu Leu Arg Ala Ile Tyr Val Pro Gln Asn Val Tyr 
1               5                   10                  15      


Cys Ile His Val Asp Glu Lys Ala Pro Met Lys Tyr Lys Thr Ala Val 
            20                  25                  30          


Gln Thr Leu Val Asn Cys Phe Glu Asn Val Phe Ile Ser Ser Lys Thr 
        35                  40                  45              


Glu Lys Val Ala Tyr Ala Gly Phe Thr Arg Leu Gln Ala Asp Ile Asn 
    50                  55                  60                  


Cys Met Lys Val Leu Val His Ser Lys Phe Gln Trp Asn Tyr Val Ile 
65                  70                  75                  80  


Asn Leu Cys Gly Gln Asp Phe Pro Ile Lys Thr Asn Arg Glu Ile Ile 
                85                  90                  95      


His Tyr Ile Arg Ser Lys Trp Ser Asp Lys Asn Ile Thr Pro Gly Val 
            100                 105                 110         


Ile Gln Pro Leu His Ile Lys Ser Lys Thr Ser Gln Ser His Leu Glu 
        115                 120                 125             


Phe Val Pro Lys Gly Ser Ile Tyr Ala Pro Pro Asn Asn Arg Phe Lys 
    130                 135                 140                 


Asp Lys Pro Pro His Asn Leu Thr Ile Tyr Phe Gly Ser Ala Tyr Tyr 
145                 150                 155                 160 


Val Leu Thr Arg Lys Phe Val Glu Phe Ile Leu Thr Asp Ile His Ala 
                165                 170                 175     


Lys Asp Met Leu Gln Trp Ser Lys Asp Ile Arg Ser Pro Glu Gln His 
            180                 185                 190         


Tyr Trp Val Thr Leu Asn Arg Leu Lys Asp Ala Pro Gly Ala Thr Pro 
        195                 200                 205             


Asn Ala Gly Trp Glu Gly Asn Val Arg Ala Ile Lys Arg Lys Ser Glu 
    210                 215                 220                 


Glu Gly Asn Val His Asp Gly Cys Lys Gly Arg Tyr Val Glu Asp Ile 
225                 230                 235                 240 


Cys Val Tyr Gly Pro Gly Asp Leu Pro Trp Leu Ile Gln Ser Pro Ser 
                245                 250                 255     


Leu Phe Ala Asn Lys Phe Glu Pro Ser Thr Asp Pro Leu Val Val Thr 
            260                 265                 270         


Cys Leu Glu Arg Arg His Arg Leu Gln Val Leu Arg Gln Ala Glu Val 
        275                 280                 285             


Pro Ile Glu Pro His Trp His Phe Gln Gln Gln Ser His Phe Asn Met 
    290                 295                 300                 


Arg Leu Asn Arg 
305             


<210>  5835
<211>  429
<212>  PRT
<213>  Homo Sapiens

<400>  5835

Met Ser Gln Leu Arg Ala Thr Lys Ser Gly Leu Val Val Arg Ala Val 
1               5                   10                  15      


Ile Cys Ile Phe Ile Phe Leu Tyr Leu Arg Asn Pro Thr Pro Ala Glu 
            20                  25                  30          


Ser Glu Glu Glu Pro Ala Gln Pro Glu Val Val Glu Cys Gly Phe Tyr 
        35                  40                  45              


Pro Asp Glu Leu Cys Ser Ala Leu Phe Glu Gly Lys Gly Ala Ala Pro 
    50                  55                  60                  


Ile Ala Lys Phe Cys Lys Thr Pro His Lys Ser Glu Ile His Ala His 
65                  70                  75                  80  


Leu His Thr Pro Gly Asn Cys Ser Arg Ile Ser Arg Gly Leu His Phe 
                85                  90                  95      


Ile Thr Arg Pro Leu Ser Ala Glu Glu Gly Asp Phe Ser Leu Ala Tyr 
            100                 105                 110         


Ile Ile Thr Ile His Lys Glu Leu Ala Met Phe Val Gln Leu Leu Arg 
        115                 120                 125             


Ala Ile Tyr Val Pro Gln Asn Val Tyr Cys Ile His Val Asp Glu Lys 
    130                 135                 140                 


Ala Pro Met Lys Tyr Lys Thr Ala Val Gln Thr Leu Val Asn Cys Phe 
145                 150                 155                 160 


Glu Asn Val Phe Ile Ser Ser Lys Thr Glu Lys Val Ala Tyr Ala Gly 
                165                 170                 175     


Phe Thr Arg Leu Gln Ala Asp Ile Asn Cys Met Lys Val Leu Val His 
            180                 185                 190         


Ser Lys Phe Gln Trp Asn Tyr Val Ile Asn Leu Cys Gly Gln Asp Phe 
        195                 200                 205             


Pro Ile Lys Thr Asn Arg Glu Ile Ile His Tyr Ile Arg Ser Lys Trp 
    210                 215                 220                 


Ser Asp Lys Asn Ile Thr Pro Gly Val Ile Gln Pro Leu His Ile Lys 
225                 230                 235                 240 


Ser Lys Thr Ser Gln Ser His Leu Glu Phe Val Pro Lys Gly Ser Ile 
                245                 250                 255     


Tyr Ala Pro Pro Asn Asn Arg Phe Lys Asp Lys Pro Pro His Asn Leu 
            260                 265                 270         


Thr Ile Tyr Phe Gly Ser Ala Tyr Tyr Val Leu Thr Arg Lys Phe Val 
        275                 280                 285             


Glu Phe Ile Leu Thr Asp Ile His Ala Lys Asp Met Leu Gln Trp Ser 
    290                 295                 300                 


Lys Asp Ile Arg Ser Pro Glu Gln His Tyr Trp Val Thr Leu Asn Arg 
305                 310                 315                 320 


Leu Lys Asp Ala Pro Gly Ala Thr Pro Asn Ala Gly Trp Glu Gly Asn 
                325                 330                 335     


Val Arg Ala Ile Lys Arg Lys Ser Glu Glu Gly Asn Val His Asp Gly 
            340                 345                 350         


Cys Lys Gly Arg Tyr Val Glu Asp Ile Cys Val Tyr Gly Pro Gly Asp 
        355                 360                 365             


Leu Pro Trp Leu Ile Gln Ser Pro Ser Leu Phe Ala Asn Lys Phe Glu 
    370                 375                 380                 


Pro Ser Thr Asp Pro Leu Val Val Thr Cys Leu Glu Arg Arg His Arg 
385                 390                 395                 400 


Leu Gln Val Leu Arg Gln Ala Glu Val Pro Ile Glu Pro His Trp His 
                405                 410                 415     


Phe Gln Gln Gln Ser His Phe Asn Met Arg Leu Asn Arg 
            420                 425                 


<210>  5836
<211>  50
<212>  PRT
<213>  Homo Sapiens

<400>  5836

Met Ala Leu Arg Val Val Arg Ser Val Arg Ala Leu Leu Cys Thr Leu 
1               5                   10                  15      


Arg Ala Val Pro Ser Pro Ala Ala Pro Cys Pro Pro Arg Pro Trp Gln 
            20                  25                  30          


Leu Gly Val Gly Ala Val Arg Thr Leu Arg Thr Gly Pro Ala Leu Leu 
        35                  40                  45              


Ser Gly 
    50  


<210>  5837
<211>  58
<212>  PRT
<213>  Homo Sapiens

<400>  5837

Met Ala Leu Arg Val Val Arg Ser Val Arg Ala Leu Leu Cys Thr Leu 
1               5                   10                  15      


Arg Ala Val Pro Ser Pro Ala Ala Pro Cys Pro Pro Arg Pro Trp Gln 
            20                  25                  30          


Leu Gly Val Gly Ala Val Arg Thr Leu Arg Thr Gly Pro Ala Leu Leu 
        35                  40                  45              


Ser Gly Ser Val Gly Arg Cys Cys Leu Leu 
    50                  55              


<210>  5838
<211>  162
<212>  PRT
<213>  Homo Sapiens

<400>  5838

Met Ala Leu Arg Val Val Arg Ser Val Arg Ala Leu Leu Cys Thr Leu 
1               5                   10                  15      


Arg Ala Val Pro Ser Pro Ala Ala Pro Cys Pro Pro Arg Pro Trp Gln 
            20                  25                  30          


Leu Gly Val Gly Ala Val Arg Thr Leu Arg Thr Gly Pro Ala Leu Leu 
        35                  40                  45              


Ser Val Arg Lys Phe Thr Glu Lys His Glu Trp Val Thr Thr Glu Asn 
    50                  55                  60                  


Gly Ile Gly Thr Val Gly Ile Ser Asn Phe Ala Gln Glu Ala Leu Gly 
65                  70                  75                  80  


Asp Val Val Tyr Cys Ser Leu Pro Glu Val Gly Thr Lys Leu Asn Lys 
                85                  90                  95      


Gln Asp Glu Phe Gly Ala Leu Glu Ser Val Lys Ala Ala Ser Glu Leu 
            100                 105                 110         


Tyr Ser Pro Leu Ser Gly Glu Val Thr Glu Ile Asn Glu Ala Leu Ala 
        115                 120                 125             


Glu Asn Pro Gly Leu Val Asn Lys Ser Cys Tyr Glu Asp Gly Lys Leu 
    130                 135                 140                 


Leu Leu Glu Ile Ser Gln Gly Ile Thr Thr Thr Val Asn Ile Leu Ser 
145                 150                 155                 160 


Arg Ile 
        


<210>  5839
<211>  173
<212>  PRT
<213>  Homo Sapiens

<400>  5839

Met Ala Leu Arg Val Val Arg Ser Val Arg Ala Leu Leu Cys Thr Leu 
1               5                   10                  15      


Arg Ala Val Pro Ser Pro Ala Ala Pro Cys Pro Pro Arg Pro Trp Gln 
            20                  25                  30          


Leu Gly Val Gly Ala Val Arg Thr Leu Arg Thr Gly Pro Ala Leu Leu 
        35                  40                  45              


Ser Val Arg Lys Phe Thr Glu Lys His Glu Trp Val Thr Thr Glu Asn 
    50                  55                  60                  


Gly Ile Gly Thr Val Gly Ile Ser Asn Phe Ala Gln Glu Ala Leu Gly 
65                  70                  75                  80  


Asp Val Val Tyr Cys Ser Leu Pro Glu Val Gly Thr Lys Leu Asn Lys 
                85                  90                  95      


Gln Asp Glu Phe Gly Ala Leu Glu Ser Val Lys Ala Ala Ser Glu Leu 
            100                 105                 110         


Tyr Ser Pro Leu Ser Gly Glu Val Thr Glu Ile Asn Glu Ala Leu Ala 
        115                 120                 125             


Glu Asn Pro Gly Leu Val Asn Lys Ser Cys Tyr Glu Asp Gly Trp Leu 
    130                 135                 140                 


Ile Lys Met Thr Leu Ser Asn Pro Ser Glu Leu Asp Glu Leu Met Ser 
145                 150                 155                 160 


Glu Glu Ala Tyr Glu Lys Tyr Ile Lys Ser Ile Glu Glu 
                165                 170             


<210>  5840
<211>  118
<212>  PRT
<213>  Homo Sapiens

<400>  5840

Ser Val Arg Ala Leu Leu Cys Thr Leu Arg Ala Val Pro Ser Pro Ala 
1               5                   10                  15      


Ala Pro Cys Pro Pro Arg Pro Trp Gln Leu Gly Val Gly Ala Val Arg 
            20                  25                  30          


Thr Leu Arg Thr Gly Pro Ala Leu Leu Ser Asp Glu Phe Gly Ala Leu 
        35                  40                  45              


Glu Ser Val Lys Ala Ala Ser Glu Leu Tyr Ser Pro Leu Ser Gly Glu 
    50                  55                  60                  


Val Thr Glu Ile Asn Glu Ala Leu Ala Glu Asn Pro Gly Leu Val Asn 
65                  70                  75                  80  


Lys Ser Cys Tyr Glu Asp Gly Trp Leu Ile Lys Met Thr Leu Ser Asn 
                85                  90                  95      


Pro Ser Glu Leu Asp Glu Leu Met Ser Glu Glu Ala Tyr Glu Lys Tyr 
            100                 105                 110         


Ile Lys Ser Ile Glu Glu 
        115             


<210>  5841
<211>  66
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5841

Xaa Cys Thr Leu Arg Ala Val Pro Ser Pro Ala Ala Pro Cys Pro Pro 
1               5                   10                  15      


Arg Pro Trp Gln Leu Gly Val Gly Ala Val Arg Thr Leu Arg Thr Gly 
            20                  25                  30          


Pro Ala Leu Leu Ser Val Arg Lys Phe Thr Glu Lys His Glu Trp Val 
        35                  40                  45              


Thr Thr Glu Asn Gly Ile Gly Thr Val Gly Ile Ser Asn Phe Ala Gln 
    50                  55                  60                  


Val Gly 
65      


<210>  5842
<211>  100
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5842

Xaa Glu Lys His Glu Trp Val Thr Thr Glu Asn Gly Ile Gly Thr Val 
1               5                   10                  15      


Gly Ile Ser Asn Phe Ala Gln Glu Ala Leu Gly Asp Val Val Tyr Cys 
            20                  25                  30          


Ser Leu Pro Glu Val Gly Thr Lys Leu Asn Lys Gln Gly Glu Val Thr 
        35                  40                  45              


Glu Ile Asn Glu Ala Leu Ala Glu Asn Pro Gly Leu Val Asn Lys Ser 
    50                  55                  60                  


Cys Tyr Glu Asp Gly Trp Leu Ile Lys Met Thr Leu Ser Asn Pro Ser 
65                  70                  75                  80  


Glu Leu Asp Glu Leu Met Ser Glu Glu Ala Tyr Glu Lys Tyr Ile Lys 
                85                  90                  95      


Ser Ile Glu Glu 
            100 


<210>  5843
<211>  105
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5843

Xaa Thr Leu Arg Thr Gly Pro Ala Leu Leu Ser Val Arg Lys Phe Thr 
1               5                   10                  15      


Glu Lys His Glu Trp Val Thr Thr Glu Asn Gly Ile Gly Thr Val Gly 
            20                  25                  30          


Ile Ser Asn Phe Ala Gln Glu Ala Leu Gly Asp Val Val Tyr Cys Ser 
        35                  40                  45              


Leu Pro Glu Val Gly Thr Lys Leu Asn Lys Gln Asp Glu Phe Gly Ala 
    50                  55                  60                  


Leu Glu Ser Val Lys Ala Ala Ser Glu Leu Tyr Ser Pro Leu Ser Gly 
65                  70                  75                  80  


Glu Val Thr Glu Ile Asn Glu Ala Leu Ala Glu Asn Pro Gly Leu Val 
                85                  90                  95      


Asn Lys Ser Cys Tyr Glu Asp Val Ser 
            100                 105 


<210>  5844
<211>  80
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5844

Xaa Val Arg Ser Val Arg Ala Leu Leu Cys Thr Leu Arg Ala Val Pro 
1               5                   10                  15      


Ser Pro Ala Ala Pro Cys Pro Pro Arg Pro Trp Gln Leu Gly Val Gly 
            20                  25                  30          


Ala Val Arg Thr Leu Arg Thr Gly Pro Ala Leu Leu Ser Val Arg Lys 
        35                  40                  45              


Phe Thr Glu Lys His Glu Trp Val Thr Thr Glu Asn Gly Ile Gly Thr 
    50                  55                  60                  


Val Gly Ile Ser Asn Phe Ala Gln Met Ser Leu Val Leu Trp Lys Val 
65                  70                  75                  80  


<210>  5845
<211>  372
<212>  PRT
<213>  Homo Sapiens

<400>  5845

Met Pro Pro Pro Gln Gln Gly Pro Cys Gly His His Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ala Leu Leu Leu Pro Ser Leu Pro Leu Thr Arg Ala Pro Val Pro 
            20                  25                  30          


Pro Gly Pro Ala Ala Ala Leu Leu Gln Ala Leu Gly Leu Arg Asp Glu 
        35                  40                  45              


Pro Gln Gly Ala Pro Arg Leu Arg Pro Val Pro Pro Val Met Trp Arg 
    50                  55                  60                  


Leu Phe Arg Arg Arg Asp Pro Gln Glu Thr Arg Ser Gly Ser Arg Arg 
65                  70                  75                  80  


Thr Ser Pro Gly Val Thr Leu Gln Pro Cys His Val Glu Glu Leu Gly 
                85                  90                  95      


Val Ala Gly Asn Ile Val Arg His Ile Pro Asp Arg Gly Ala Pro Thr 
            100                 105                 110         


Arg Ala Ser Glu Pro Ala Ser Ala Ala Gly His Cys Pro Glu Trp Thr 
        115                 120                 125             


Val Val Phe Asp Leu Ser Ala Val Glu Pro Ala Glu Arg Pro Ser Arg 
    130                 135                 140                 


Ala Arg Leu Glu Leu Arg Phe Ala Ala Ala Ala Ala Ala Ala Pro Glu 
145                 150                 155                 160 


Gly Gly Trp Glu Leu Ser Val Ala Gln Ala Gly Gln Gly Ala Gly Ala 
                165                 170                 175     


Asp Pro Gly Pro Val Leu Leu Arg Gln Leu Val Pro Ala Leu Gly Pro 
            180                 185                 190         


Pro Val Arg Ala Glu Leu Leu Gly Ala Ala Trp Ala Arg Asn Ala Ser 
        195                 200                 205             


Trp Pro Arg Ser Leu Arg Leu Ala Leu Ala Leu Arg Pro Arg Ala Pro 
    210                 215                 220                 


Ala Ala Cys Ala Arg Leu Ala Glu Ala Ser Leu Leu Leu Val Thr Leu 
225                 230                 235                 240 


Asp Pro Arg Leu Cys His Pro Leu Ala Arg Pro Arg Arg Asp Ala Glu 
                245                 250                 255     


Pro Val Leu Gly Gly Gly Pro Gly Gly Ala Cys Arg Ala Arg Arg Leu 
            260                 265                 270         


Tyr Val Ser Phe Arg Glu Val Gly Trp His Arg Trp Val Ile Ala Pro 
        275                 280                 285             


Arg Gly Phe Leu Ala Asn Tyr Cys Gln Gly Gln Cys Ala Leu Pro Val 
    290                 295                 300                 


Ala Leu Ser Gly Ser Gly Gly Pro Pro Ala Leu Asn His Ala Val Leu 
305                 310                 315                 320 


Arg Ala Leu Met His Ala Ala Ala Pro Gly Ala Ala Asp Leu Pro Cys 
                325                 330                 335     


Cys Val Pro Ala Arg Leu Ser Pro Ile Ser Val Leu Phe Phe Asp Asn 
            340                 345                 350         


Ser Asp Asn Val Val Leu Arg Gln Tyr Glu Asp Met Val Val Asp Glu 
        355                 360                 365             


Cys Gly Cys Arg 
    370         


<210>  5846
<211>  478
<212>  PRT
<213>  Homo Sapiens

<400>  5846

Met Ala His Val Pro Ala Arg Thr Ser Pro Gly Pro Gly Pro Gln Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Pro Leu Phe Leu Leu Leu Leu Arg Asp Val Ala 
            20                  25                  30          


Gly Ser His Arg Ala Pro Ala Trp Ser Ala Leu Pro Ala Ala Ala Asp 
        35                  40                  45              


Gly Leu Gln Gly Asp Arg Asp Leu Gln Arg His Pro Gly Asp Ala Ala 
    50                  55                  60                  


Ala Thr Leu Gly Pro Ser Ala Gln Asp Met Val Ala Val His Met His 
65                  70                  75                  80  


Arg Leu Tyr Glu Lys Tyr Ser Arg Gln Gly Ala Arg Pro Gly Gly Gly 
                85                  90                  95      


Asn Thr Val Arg Ser Phe Arg Ala Arg Leu Glu Val Val Asp Gln Lys 
            100                 105                 110         


Ala Val Tyr Phe Phe Asn Leu Thr Ser Met Gln Asp Ser Glu Met Ile 
        115                 120                 125             


Leu Thr Ala Thr Phe His Phe Tyr Ser Glu Pro Pro Arg Trp Pro Arg 
    130                 135                 140                 


Ala Leu Glu Val Leu Cys Lys Pro Arg Ala Lys Asn Ala Ser Gly Arg 
145                 150                 155                 160 


Pro Leu Pro Leu Gly Pro Pro Thr Arg Gln His Leu Leu Phe Arg Ser 
                165                 170                 175     


Leu Ser Gln Asn Thr Ala Thr Gln Gly Leu Leu Arg Gly Ala Met Ala 
            180                 185                 190         


Leu Ala Pro Pro Pro Arg Gly Leu Trp Gln Ala Lys Asp Ile Ser Pro 
        195                 200                 205             


Ile Val Lys Ala Ala Arg Arg Asp Gly Glu Leu Leu Leu Ser Ala Gln 
    210                 215                 220                 


Leu Asp Ser Glu Glu Arg Asp Pro Gly Val Pro Arg Pro Ser Pro Tyr 
225                 230                 235                 240 


Ala Pro Tyr Ile Leu Val Tyr Ala Asn Asp Leu Ala Ile Ser Glu Pro 
                245                 250                 255     


Asn Ser Val Ala Val Thr Leu Gln Arg Tyr Asp Pro Phe Pro Ala Gly 
            260                 265                 270         


Asp Pro Glu Pro Arg Ala Ala Pro Asn Asn Ser Ala Asp Pro Arg Val 
        275                 280                 285             


Arg Arg Ala Ala Gln Ala Thr Gly Pro Leu Gln Asp Asn Glu Leu Pro 
    290                 295                 300                 


Gly Leu Asp Glu Arg Pro Pro Arg Ala His Ala Gln His Phe His Lys 
305                 310                 315                 320 


His Gln Leu Trp Pro Ser Pro Phe Arg Ala Leu Lys Pro Arg Pro Gly 
                325                 330                 335     


Arg Lys Asp Arg Arg Lys Lys Gly Gln Glu Val Phe Met Ala Ala Ser 
            340                 345                 350         


Gln Val Leu Asp Phe Asp Glu Lys Thr Met Gln Lys Ala Arg Arg Lys 
        355                 360                 365             


Gln Trp Asp Glu Pro Arg Val Cys Ser Arg Arg Tyr Leu Lys Val Asp 
    370                 375                 380                 


Phe Ala Asp Ile Gly Trp Asn Glu Trp Ile Ile Ser Pro Lys Ser Phe 
385                 390                 395                 400 


Asp Ala Tyr Tyr Cys Ala Gly Ala Cys Glu Phe Pro Met Pro Lys Ile 
                405                 410                 415     


Val Arg Pro Ser Asn His Ala Thr Ile Gln Ser Ile Val Arg Ala Val 
            420                 425                 430         


Gly Ile Ile Pro Gly Ile Pro Glu Pro Cys Cys Val Pro Asp Lys Met 
        435                 440                 445             


Asn Ser Leu Gly Val Leu Phe Leu Asp Glu Asn Arg Asn Val Val Leu 
    450                 455                 460                 


Lys Val Tyr Pro Asn Met Ser Val Asp Thr Cys Ala Cys Arg 
465                 470                 475             


<210>  5847
<211>  407
<212>  PRT
<213>  Homo Sapiens

<400>  5847

Met Val Leu Ala Ala Pro Leu Leu Leu Gly Phe Leu Leu Leu Ala Leu 
1               5                   10                  15      


Glu Leu Arg Pro Arg Gly Glu Ala Ala Glu Gly Pro Ala Ala Ala Ala 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Val Gly Gly Glu Arg Ser 
        35                  40                  45              


Ser Arg Pro Ala Pro Ser Val Ala Pro Glu Pro Asp Gly Cys Pro Val 
    50                  55                  60                  


Cys Val Trp Arg Gln His Ser Arg Glu Leu Arg Leu Glu Ser Ile Lys 
65                  70                  75                  80  


Ser Gln Ile Leu Ser Lys Leu Arg Leu Lys Glu Ala Pro Asn Ile Ser 
                85                  90                  95      


Arg Glu Val Val Lys Gln Leu Leu Pro Lys Ala Pro Pro Leu Gln Gln 
            100                 105                 110         


Ile Leu Asp Leu His Asp Phe Gln Gly Asp Ala Leu Gln Pro Glu Asp 
        115                 120                 125             


Phe Leu Glu Glu Asp Glu Tyr His Ala Thr Thr Glu Thr Val Ile Ser 
    130                 135                 140                 


Met Ala Gln Glu Thr Asp Pro Ala Val Gln Thr Asp Gly Ser Pro Leu 
145                 150                 155                 160 


Cys Cys His Phe His Phe Ser Pro Lys Val Met Phe Thr Lys Val Leu 
                165                 170                 175     


Lys Ala Gln Leu Trp Val Tyr Leu Arg Pro Val Pro Arg Pro Ala Thr 
            180                 185                 190         


Val Tyr Leu Gln Ile Leu Arg Leu Lys Pro Leu Thr Gly Glu Gly Thr 
        195                 200                 205             


Ala Gly Gly Gly Gly Gly Gly Arg Arg His Ile Arg Ile Arg Ser Leu 
    210                 215                 220                 


Lys Ile Glu Leu His Ser Arg Ser Gly His Trp Gln Ser Ile Asp Phe 
225                 230                 235                 240 


Lys Gln Val Leu His Ser Trp Phe Arg Gln Pro Gln Ser Asn Trp Gly 
                245                 250                 255     


Ile Glu Ile Asn Ala Phe Asp Pro Ser Gly Thr Asp Leu Ala Val Thr 
            260                 265                 270         


Ser Leu Gly Pro Gly Ala Glu Gly Leu His Pro Phe Met Glu Leu Arg 
        275                 280                 285             


Val Leu Glu Asn Thr Lys Arg Ser Arg Arg Asn Leu Gly Leu Asp Cys 
    290                 295                 300                 


Asp Glu His Ser Ser Glu Ser Arg Cys Cys Arg Tyr Pro Leu Thr Val 
305                 310                 315                 320 


Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile Ile Ala Pro Lys Arg Tyr 
                325                 330                 335     


Lys Ala Asn Tyr Cys Ser Gly Gln Cys Glu Tyr Met Phe Met Gln Lys 
            340                 345                 350         


Tyr Pro His Thr His Leu Val Gln Gln Ala Asn Pro Arg Gly Ser Ala 
        355                 360                 365             


Gly Pro Cys Cys Thr Pro Thr Lys Met Ser Pro Ile Asn Met Leu Tyr 
    370                 375                 380                 


Phe Asn Asp Lys Gln Gln Ile Ile Tyr Gly Lys Ile Pro Gly Met Val 
385                 390                 395                 400 


Val Asp Arg Cys Gly Cys Ser 
                405         


<210>  5848
<211>  380
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5848

Xaa Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Val 
1               5                   10                  15      


Gly Gly Glu Arg Ser Ser Arg Pro Ala Pro Ser Val Ala Pro Glu Pro 
            20                  25                  30          


Asp Gly Cys Pro Val Cys Val Trp Arg Gln His Ser Arg Glu Leu Arg 
        35                  40                  45              


Leu Glu Ser Ile Lys Ser Gln Ile Leu Ser Lys Leu Arg Leu Lys Glu 
    50                  55                  60                  


Ala Pro Asn Ile Ser Arg Glu Val Val Lys Gln Leu Leu Pro Lys Ala 
65                  70                  75                  80  


Pro Pro Leu Gln Gln Ile Leu Asp Leu His Asp Phe Gln Gly Asp Ala 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Leu Glu Glu Asp Glu Tyr His Ala Thr Thr 
            100                 105                 110         


Glu Thr Val Ile Ser Met Ala Gln Glu Thr Asp Pro Ala Val Gln Thr 
        115                 120                 125             


Asp Gly Ser Pro Leu Cys Cys His Phe His Phe Ser Pro Lys Val Met 
    130                 135                 140                 


Phe Thr Lys Val Leu Lys Ala Gln Leu Trp Val Tyr Leu Arg Pro Val 
145                 150                 155                 160 


Pro Arg Pro Ala Thr Val Tyr Leu Gln Ile Leu Arg Leu Lys Pro Leu 
                165                 170                 175     


Thr Gly Glu Gly Thr Ala Gly Gly Gly Gly Gly Gly Arg Arg His Ile 
            180                 185                 190         


Arg Ile Arg Ser Leu Lys Ile Glu Leu His Ser Arg Ser Gly His Trp 
        195                 200                 205             


Gln Ser Ile Asp Phe Lys Gln Val Leu His Ser Trp Phe Arg Gln Pro 
    210                 215                 220                 


Gln Ser Asn Trp Gly Ile Glu Ile Asn Ala Phe Asp Pro Ser Gly Thr 
225                 230                 235                 240 


Asp Leu Ala Val Thr Ser Leu Gly Pro Gly Ala Glu Gly Leu His Pro 
                245                 250                 255     


Phe Met Glu Leu Arg Val Leu Glu Asn Thr Lys Arg Ser Arg Arg Asn 
            260                 265                 270         


Leu Gly Leu Asp Cys Asp Glu His Ser Ser Glu Ser Arg Cys Cys Arg 
        275                 280                 285             


Tyr Pro Leu Thr Val Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile Ile 
    290                 295                 300                 


Ala Pro Lys Arg Tyr Lys Ala Asn Tyr Cys Ser Gly Gln Cys Glu Tyr 
305                 310                 315                 320 


Met Phe Met Gln Lys Tyr Pro His Thr His Leu Val Gln Gln Ala Asn 
                325                 330                 335     


Pro Arg Gly Ser Ala Gly Pro Cys Cys Thr Pro Thr Lys Met Ser Pro 
            340                 345                 350         


Ile Asn Met Leu Tyr Phe Asn Asp Lys Gln Gln Ile Ile Tyr Gly Lys 
        355                 360                 365             


Ile Pro Gly Met Val Val Asp Arg Cys Gly Cys Ser 
    370                 375                 380 


<210>  5849
<211>  6
<212>  PRT
<213>  Homo Sapiens

<400>  5849

Met Pro Gly Gln Glu Leu 
1               5       


<210>  5850
<211>  113
<212>  PRT
<213>  Homo Sapiens

<400>  5850

Met Pro Gly Gln Glu Leu Arg Thr Val Asn Gly Ser Gln Met Leu Leu 
1               5                   10                  15      


Val Leu Leu Val Leu Ser Trp Leu Pro His Gly Gly Ala Leu Ser Leu 
            20                  25                  30          


Ala Glu Ala Ser Arg Ala Ser Phe Pro Gly Pro Ser Glu Leu His Ser 
        35                  40                  45              


Glu Asp Ser Arg Phe Arg Glu Leu Arg Lys Arg Tyr Glu Asp Leu Leu 
    50                  55                  60                  


Thr Arg Leu Arg Ala Asn Gln Ser Trp Glu Asp Ser Asn Thr Asp Leu 
65                  70                  75                  80  


Val Pro Ala Pro Ala Val Arg Ile Leu Thr Pro Glu Val Arg Leu Gly 
                85                  90                  95      


Ser Gly Gly His Leu His Leu Arg Ile Ser Arg Ala Ala Leu Pro Glu 
            100                 105                 110         


Gly 
    


<210>  5851
<211>  308
<212>  PRT
<213>  Homo Sapiens

<400>  5851

Met Pro Gly Gln Glu Leu Arg Thr Val Asn Gly Ser Gln Met Leu Leu 
1               5                   10                  15      


Val Leu Leu Val Leu Ser Trp Leu Pro His Gly Gly Ala Leu Ser Leu 
            20                  25                  30          


Ala Glu Ala Ser Arg Ala Ser Phe Pro Gly Pro Ser Glu Leu His Ser 
        35                  40                  45              


Glu Asp Ser Arg Phe Arg Glu Leu Arg Lys Arg Tyr Glu Asp Leu Leu 
    50                  55                  60                  


Thr Arg Leu Arg Ala Asn Gln Ser Trp Glu Asp Ser Asn Thr Asp Leu 
65                  70                  75                  80  


Val Pro Ala Pro Ala Val Arg Ile Leu Thr Pro Glu Val Arg Leu Gly 
                85                  90                  95      


Ser Gly Gly His Leu His Leu Arg Ile Ser Arg Ala Ala Leu Pro Glu 
            100                 105                 110         


Gly Leu Pro Glu Ala Ser Arg Leu His Arg Ala Leu Phe Arg Leu Ser 
        115                 120                 125             


Pro Thr Ala Ser Arg Ser Trp Asp Val Thr Arg Pro Leu Arg Arg Gln 
    130                 135                 140                 


Leu Ser Leu Ala Arg Pro Gln Ala Pro Ala Leu His Leu Arg Leu Ser 
145                 150                 155                 160 


Pro Pro Pro Ser Gln Ser Asp Gln Leu Leu Ala Glu Ser Ser Ser Ala 
                165                 170                 175     


Arg Pro Gln Leu Glu Leu His Leu Arg Pro Gln Ala Ala Arg Gly Arg 
            180                 185                 190         


Arg Arg Ala Arg Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly 
        195                 200                 205             


Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly 
    210                 215                 220                 


Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys 
225                 230                 235                 240 


Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln 
                245                 250                 255     


Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro 
            260                 265                 270         


Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr 
        275                 280                 285             


Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp 
    290                 295                 300                 


Cys His Cys Ile 
305             


<210>  5852
<211>  429
<212>  PRT
<213>  Homo Sapiens

<400>  5852

Met Cys Pro Gly Ala Leu Trp Val Ala Leu Pro Leu Leu Ser Leu Leu 
1               5                   10                  15      


Ala Gly Ser Leu Gln Gly Lys Pro Leu Gln Ser Trp Gly Arg Gly Ser 
            20                  25                  30          


Ala Gly Gly Asn Ala His Ser Pro Leu Gly Val Pro Gly Gly Gly Leu 
        35                  40                  45              


Pro Glu His Thr Phe Asn Leu Lys Met Phe Leu Glu Asn Val Lys Val 
    50                  55                  60                  


Asp Phe Leu Arg Ser Leu Asn Leu Ser Gly Val Pro Ser Gln Asp Lys 
65                  70                  75                  80  


Thr Arg Val Glu Pro Pro Gln Tyr Met Ile Asp Leu Tyr Asn Arg Tyr 
                85                  90                  95      


Thr Ser Asp Lys Ser Thr Thr Pro Ala Ser Asn Ile Val Arg Ser Phe 
            100                 105                 110         


Ser Met Glu Asp Ala Ile Ser Ile Thr Ala Thr Glu Asp Phe Pro Phe 
        115                 120                 125             


Gln Lys His Ile Leu Leu Phe Asn Ile Ser Ile Pro Arg His Glu Gln 
    130                 135                 140                 


Ile Thr Arg Ala Glu Leu Arg Leu Tyr Val Ser Cys Gln Asn His Val 
145                 150                 155                 160 


Asp Pro Ser His Asp Leu Lys Gly Ser Val Val Ile Tyr Asp Val Leu 
                165                 170                 175     


Asp Gly Thr Asp Ala Trp Asp Ser Ala Thr Glu Thr Lys Thr Phe Leu 
            180                 185                 190         


Val Ser Gln Asp Ile Gln Asp Glu Gly Trp Glu Thr Leu Glu Val Ser 
        195                 200                 205             


Ser Ala Val Lys Arg Trp Val Arg Ser Asp Ser Thr Lys Ser Lys Asn 
    210                 215                 220                 


Lys Leu Glu Val Thr Val Glu Ser His Arg Lys Gly Cys Asp Thr Leu 
225                 230                 235                 240 


Asp Ile Ser Val Pro Pro Gly Ser Arg Asn Leu Pro Phe Phe Val Val 
                245                 250                 255     


Phe Ser Asn Asp His Ser Ser Gly Thr Lys Glu Thr Arg Leu Glu Leu 
            260                 265                 270         


Arg Glu Met Ile Ser His Glu Gln Glu Ser Val Leu Lys Lys Leu Ser 
        275                 280                 285             


Lys Asp Gly Ser Thr Glu Ala Gly Glu Ser Ser His Glu Glu Asp Thr 
    290                 295                 300                 


Asp Gly His Val Ala Ala Gly Ser Thr Leu Ala Arg Arg Lys Arg Ser 
305                 310                 315                 320 


Ala Gly Ala Gly Ser His Cys Gln Lys Thr Ser Leu Arg Val Asn Phe 
                325                 330                 335     


Glu Asp Ile Gly Trp Asp Ser Trp Ile Ile Ala Pro Lys Glu Tyr Glu 
            340                 345                 350         


Ala Tyr Glu Cys Lys Gly Gly Cys Phe Phe Pro Leu Ala Asp Asp Val 
        355                 360                 365             


Thr Pro Thr Lys His Ala Ile Val Gln Thr Leu Val His Leu Lys Phe 
    370                 375                 380                 


Pro Thr Lys Val Gly Lys Ala Cys Cys Val Pro Thr Lys Leu Ser Pro 
385                 390                 395                 400 


Ile Ser Val Leu Tyr Lys Asp Asp Met Gly Val Pro Thr Leu Lys Tyr 
                405                 410                 415     


His Tyr Glu Gly Met Ser Val Ala Glu Cys Gly Cys Arg 
            420                 425                 


<210>  5853
<211>  364
<212>  PRT
<213>  Homo Sapiens

<400>  5853

Met Leu Arg Phe Leu Pro Asp Leu Ala Phe Ser Phe Leu Leu Ile Leu 
1               5                   10                  15      


Ala Leu Gly Gln Ala Val Gln Phe Gln Glu Tyr Val Phe Leu Gln Phe 
            20                  25                  30          


Leu Gly Leu Asp Lys Ala Pro Ser Pro Gln Lys Phe Gln Pro Val Pro 
        35                  40                  45              


Tyr Ile Leu Lys Lys Ile Phe Gln Asp Arg Glu Ala Ala Ala Thr Thr 
    50                  55                  60                  


Gly Val Ser Arg Asp Leu Cys Tyr Val Lys Glu Leu Gly Val Arg Gly 
65                  70                  75                  80  


Asn Val Leu Arg Phe Leu Pro Asp Gln Gly Phe Phe Leu Tyr Pro Lys 
                85                  90                  95      


Lys Ile Ser Gln Ala Ser Ser Cys Leu Gln Lys Leu Leu Tyr Phe Asn 
            100                 105                 110         


Leu Ser Ala Ile Lys Glu Arg Glu Gln Leu Thr Leu Ala Gln Leu Gly 
        115                 120                 125             


Leu Asp Leu Gly Pro Asn Ser Tyr Tyr Asn Leu Gly Pro Glu Leu Glu 
    130                 135                 140                 


Leu Ala Leu Phe Leu Val Gln Glu Pro His Val Trp Gly Gln Thr Thr 
145                 150                 155                 160 


Pro Lys Pro Gly Lys Met Phe Val Leu Arg Ser Val Pro Trp Pro Gln 
                165                 170                 175     


Gly Ala Val His Phe Asn Leu Leu Asp Val Ala Lys Asp Trp Asn Asp 
            180                 185                 190         


Asn Pro Arg Lys Asn Phe Gly Leu Phe Leu Glu Ile Leu Val Lys Glu 
        195                 200                 205             


Asp Arg Asp Ser Gly Val Asn Phe Gln Pro Glu Asp Thr Cys Ala Arg 
    210                 215                 220                 


Leu Arg Cys Ser Leu His Ala Ser Leu Leu Val Val Thr Leu Asn Pro 
225                 230                 235                 240 


Asp Gln Cys His Pro Ser Arg Lys Arg Arg Ala Ala Ile Pro Val Pro 
                245                 250                 255     


Lys Leu Ser Cys Lys Asn Leu Cys His Arg His Gln Leu Phe Ile Asn 
            260                 265                 270         


Phe Arg Asp Leu Gly Trp His Lys Trp Ile Ile Ala Pro Lys Gly Phe 
        275                 280                 285             


Met Ala Asn Tyr Cys His Gly Glu Cys Pro Phe Ser Leu Thr Ile Ser 
    290                 295                 300                 


Leu Asn Ser Ser Asn Tyr Ala Phe Met Gln Ala Leu Met His Ala Val 
305                 310                 315                 320 


Asp Pro Glu Ile Pro Gln Ala Val Cys Ile Pro Thr Lys Leu Ser Pro 
                325                 330                 335     


Ile Ser Met Leu Tyr Gln Asp Asn Asn Asp Asn Val Ile Leu Arg His 
            340                 345                 350         


Tyr Glu Asp Met Val Val Asp Glu Cys Gly Cys Gly 
        355                 360                 


<210>  5854
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  5854

Met Arg Leu Pro Lys Leu Leu Thr Phe Leu Leu Trp Tyr Leu Ala Trp 
1               5                   10                  15      


Leu Asp Leu Glu Phe Ile Cys Thr Val Leu Gly Ala Pro Asp Leu Gly 
            20                  25                  30          


Gln Arg Pro Gln Gly Thr Arg Pro Gly Leu Ala Lys Ala Glu Ala Lys 
        35                  40                  45              


Glu Arg Pro Pro Leu Ala Arg Asn Val Phe Arg Pro Gly Gly His Ser 
    50                  55                  60                  


Tyr Gly Gly Gly Ala Thr Asn Ala Asn Ala Arg Ala Lys Gly Gly Thr 
65                  70                  75                  80  


Gly Gln Thr Gly Gly Leu Thr Gln Pro Lys Lys Asp Glu Pro Lys Lys 
                85                  90                  95      


Leu Pro Pro Arg Pro Gly Gly Pro Glu Pro Lys Pro Gly His Pro Pro 
            100                 105                 110         


Gln Thr Arg Gln Ala Thr Ala Arg Thr Val Thr Pro Lys Gly Gln Leu 
        115                 120                 125             


Pro Gly Gly Lys Ala Pro Pro Lys Ala Gly Ser Val Pro Ser Ser Phe 
    130                 135                 140                 


Leu Leu Lys Lys Ala Arg Glu Pro Gly Pro Pro Arg Glu Pro Lys Glu 
145                 150                 155                 160 


Pro Phe Arg Pro Pro Pro Ile Thr Pro His Glu Tyr Met Leu Ser Leu 
                165                 170                 175     


Tyr Arg Thr Leu Ser Asp Ala Asp Arg Lys Gly Gly Asn Ser Ser Val 
            180                 185                 190         


Lys Leu Glu Ala Gly Leu Ala Asn Thr Ile Thr Ser Phe Ile Asp Lys 
        195                 200                 205             


Gly Gln Asp Asp Arg Gly Pro Val Val Arg Lys Gln Arg Tyr Val Phe 
    210                 215                 220                 


Asp Ile Ser Ala Leu Glu Lys Asp Gly Leu Leu Gly Ala Glu Leu Arg 
225                 230                 235                 240 


Ile Leu Arg Lys Lys Pro Ser Asp Thr Ala Lys Pro Ala Ala Pro Gly 
                245                 250                 255     


Gly Gly Arg Ala Ala Gln Leu Lys Leu Ser Ser Cys Pro Ser Gly Arg 
            260                 265                 270         


Gln Pro Ala Ala Leu Leu Asp Val Arg Ser Val Pro Gly Leu Asp Gly 
        275                 280                 285             


Ser Gly Trp Glu Val Phe Asp Ile Trp Lys Leu Phe Arg Asn Phe Lys 
    290                 295                 300                 


Asn Ser Ala Gln Leu Cys Leu Glu Leu Glu Ala Trp Glu Arg Gly Arg 
305                 310                 315                 320 


Ala Val Asp Leu Arg Gly Leu Gly Phe Asp Arg Ala Ala Arg Gln Val 
                325                 330                 335     


His Glu Lys Ala Leu Phe Leu Val Phe Gly Arg Thr Lys Lys Arg Asp 
            340                 345                 350         


Leu Phe Phe Asn Glu Ile Lys Ala Arg Ser Gly Gln Asp Asp Lys Thr 
        355                 360                 365             


Val Tyr Glu Tyr Leu Phe Ser Gln Arg Arg Lys Arg Arg Ala Pro Leu 
    370                 375                 380                 


Ala Thr Arg Gln Gly Lys Arg Pro Ser Lys Asn Leu Lys Ala Arg Cys 
385                 390                 395                 400 


Ser Arg Lys Ala Leu His Val Asn Phe Lys Asp Met Gly Trp Asp Asp 
                405                 410                 415     


Trp Ile Ile Ala Pro Leu Glu Tyr Glu Ala Phe His Cys Glu Gly Leu 
            420                 425                 430         


Cys Glu Phe Pro Leu Arg Ser His Leu Glu Pro Thr Asn His Ala Val 
        435                 440                 445             


Ile Gln Thr Leu Met Asn Ser Met Asp Pro Glu Ser Thr Pro Pro Thr 
    450                 455                 460                 


Cys Cys Val Pro Thr Arg Leu Ser Pro Ile Ser Ile Leu Phe Ile Asp 
465                 470                 475                 480 


Ser Ala Asn Asn Val Val Tyr Lys Gln Tyr Glu Asp Met Val Val Glu 
                485                 490                 495     


Ser Cys Gly Cys Arg 
            500     


<210>  5855
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  5855

Met Arg Leu Pro Lys Leu Leu Thr Phe Leu Leu Trp Tyr Leu Ala Trp 
1               5                   10                  15      


Leu Asp Leu Glu Phe Ile Cys Thr Val Leu Gly Ala Pro Asp Leu Gly 
            20                  25                  30          


Gln Arg Pro Gln Gly Thr Arg Pro Gly Leu Ala Lys Ala Glu Ala Lys 
        35                  40                  45              


Glu Arg Pro Pro Leu Ala Arg Asn Val Phe Arg Pro Gly Gly His Ser 
    50                  55                  60                  


Tyr Gly Gly Gly Ala Thr Asn Ala Asn Ala Arg Ala Lys Gly Gly Thr 
65                  70                  75                  80  


Gly Gln Thr Gly Gly Leu Thr Gln Pro Lys Lys Asp Glu Pro Lys Lys 
                85                  90                  95      


Leu Pro Pro Arg Pro Gly Gly Pro Glu Pro Lys Pro Gly His Pro Pro 
            100                 105                 110         


Gln Thr Arg Gln Ala Thr Ala Arg Thr Val Thr Pro Lys Gly Gln Leu 
        115                 120                 125             


Pro Gly Gly Lys Ala Pro Pro Lys Ala Gly Ser Val Pro Ser Ser Phe 
    130                 135                 140                 


Leu Leu Lys Lys Ala Arg Glu Pro Gly Pro Pro Arg Glu Pro Lys Glu 
145                 150                 155                 160 


Pro Phe Arg Pro Pro Pro Ile Thr Pro His Glu Tyr Met Leu Ser Leu 
                165                 170                 175     


Tyr Arg Thr Leu Ser Asp Ala Asp Arg Lys Gly Gly Asn Ser Ser Val 
            180                 185                 190         


Lys Leu Glu Ala Gly Leu Ala Asn Thr Ile Thr Ser Phe Ile Asp Lys 
        195                 200                 205             


Gly Gln Asp Asp Arg Gly Pro Val Val Arg Lys Gln Arg Tyr Val Phe 
    210                 215                 220                 


Asp Ile Ser Ala Leu Glu Lys Asp Gly Leu Leu Gly Ala Glu Leu Arg 
225                 230                 235                 240 


Ile Leu Arg Lys Lys Pro Ser Asp Thr Ala Lys Pro Ala Ala Pro Gly 
                245                 250                 255     


Gly Gly Arg Ala Ala Gln Leu Lys Leu Ser Ser Cys Pro Ser Gly Arg 
            260                 265                 270         


Gln Pro Ala Ala Leu Leu Asp Val Arg Ser Val Pro Gly Leu Asp Gly 
        275                 280                 285             


Ser Gly Trp Glu Val Phe Asp Ile Trp Lys Leu Phe Arg Asn Phe Lys 
    290                 295                 300                 


Asn Ser Ala Gln Leu Cys Leu Glu Leu Glu Ala Trp Glu Arg Gly Arg 
305                 310                 315                 320 


Ala Val Asp Leu Arg Gly Leu Gly Phe Asp Arg Ala Ala Arg Gln Val 
                325                 330                 335     


His Glu Lys Ala Leu Phe Leu Val Phe Gly Arg Thr Lys Lys Arg Asp 
            340                 345                 350         


Leu Phe Phe Asn Glu Ile Lys Ala Arg Ser Gly Gln Asp Asp Lys Thr 
        355                 360                 365             


Val Tyr Glu Tyr Leu Phe Ser Gln Arg Arg Lys Arg Arg Ala Pro Leu 
    370                 375                 380                 


Ala Thr Arg Gln Gly Lys Arg Pro Ser Lys Asn Leu Lys Ala Arg Cys 
385                 390                 395                 400 


Ser Arg Lys Ala Leu His Val Asn Phe Lys Asp Met Gly Trp Asp Asp 
                405                 410                 415     


Trp Ile Ile Ala Pro Leu Glu Tyr Glu Ala Phe His Cys Glu Gly Leu 
            420                 425                 430         


Cys Glu Phe Pro Leu Arg Ser His Leu Glu Pro Thr Asn His Ala Val 
        435                 440                 445             


Ile Gln Thr Leu Met Asn Ser Met Asp Pro Glu Ser Thr Pro Pro Thr 
    450                 455                 460                 


Cys Cys Val Pro Thr Arg Leu Ser Pro Ile Ser Ile Leu Phe Ile Asp 
465                 470                 475                 480 


Ser Ala Asn Asn Val Val Tyr Lys Gln Tyr Glu Asp Met Val Val Glu 
                485                 490                 495     


Ser Cys Gly Cys Arg 
            500     


<210>  5856
<211>  271
<212>  PRT
<213>  Homo Sapiens

<400>  5856

Met Asp Thr Pro Arg Val Leu Leu Ser Ala Val Phe Leu Ile Ser Phe 
1               5                   10                  15      


Leu Trp Asp Leu Pro Gly Phe Gln Gln Ala Ser Ile Ser Ser Ser Ser 
            20                  25                  30          


Ser Ser Ala Glu Leu Gly Ser Thr Lys Gly Met Arg Ser Arg Lys Glu 
        35                  40                  45              


Gly Lys Met Gln Arg Ala Pro Arg Asp Ser Asp Ala Gly Arg Glu Gly 
    50                  55                  60                  


Gln Glu Pro Gln Pro Arg Pro Gln Asp Glu Pro Arg Ala Gln Gln Pro 
65                  70                  75                  80  


Arg Ala Gln Glu Pro Pro Gly Arg Gly Pro Arg Val Val Pro His Glu 
                85                  90                  95      


Tyr Met Leu Ser Ile Tyr Arg Thr Tyr Ser Ile Ala Glu Lys Leu Gly 
            100                 105                 110         


Ile Asn Ala Ser Phe Phe Gln Ser Ser Lys Ser Ala Asn Thr Ile Thr 
        115                 120                 125             


Ser Phe Val Asp Arg Gly Leu Asp Asp Leu Ser His Thr Pro Leu Arg 
    130                 135                 140                 


Arg Gln Lys Tyr Leu Phe Asp Val Ser Met Leu Ser Asp Lys Glu Glu 
145                 150                 155                 160 


Leu Val Gly Ala Glu Leu Arg Leu Phe Arg Gln Ala Pro Ser Ala Pro 
                165                 170                 175     


Trp Gly Pro Pro Ala Gly Pro Leu His Val Gln Leu Phe Pro Cys Leu 
            180                 185                 190         


Ser Pro Leu Leu Leu Asp Ala Arg Thr Leu Asp Pro Gln Gly Ala Pro 
        195                 200                 205             


Pro Ala Gly Trp Glu Val Phe Asp Val Trp Gln Gly Leu Arg His Gln 
    210                 215                 220                 


Pro Trp Lys Gln Leu Cys Leu Glu Leu Arg Ala Ala Pro Gly Pro Ala 
225                 230                 235                 240 


Glu Ser Gly Leu Arg Pro Glu Gly Ala Ala Ser Pro Gly Ala Gly Pro 
                245                 250                 255     


Ala Gly Gly Ile His Gln Ile Pro Ala Ala Ala Cys Pro Pro Asn 
            260                 265                 270     


<210>  5857
<211>  455
<212>  PRT
<213>  Homo Sapiens

<400>  5857

Met Asp Thr Pro Arg Val Leu Leu Ser Ala Val Phe Leu Ile Ser Phe 
1               5                   10                  15      


Leu Trp Asp Leu Pro Gly Phe Gln Gln Ala Ser Ile Ser Ser Ser Ser 
            20                  25                  30          


Ser Ser Ala Glu Leu Gly Ser Thr Lys Gly Met Arg Ser Arg Lys Glu 
        35                  40                  45              


Gly Lys Met Gln Arg Ala Pro Arg Asp Ser Asp Ala Gly Arg Glu Gly 
    50                  55                  60                  


Gln Glu Pro Gln Pro Arg Pro Gln Asp Glu Pro Arg Ala Gln Gln Pro 
65                  70                  75                  80  


Arg Ala Gln Glu Pro Pro Gly Arg Gly Pro Arg Val Val Pro His Glu 
                85                  90                  95      


Tyr Met Leu Ser Ile Tyr Arg Thr Tyr Ser Ile Ala Glu Lys Leu Gly 
            100                 105                 110         


Ile Asn Ala Ser Phe Phe Gln Ser Ser Lys Ser Ala Asn Thr Ile Thr 
        115                 120                 125             


Ser Phe Val Asp Arg Gly Leu Asp Asp Leu Ser His Thr Pro Leu Arg 
    130                 135                 140                 


Arg Gln Lys Tyr Leu Phe Asp Val Ser Met Leu Ser Asp Lys Glu Glu 
145                 150                 155                 160 


Leu Val Gly Ala Glu Leu Arg Leu Phe Arg Gln Ala Pro Ser Ala Pro 
                165                 170                 175     


Trp Gly Pro Pro Ala Gly Pro Leu His Val Gln Leu Phe Pro Cys Leu 
            180                 185                 190         


Ser Pro Leu Leu Leu Asp Ala Arg Thr Leu Asp Pro Gln Gly Ala Pro 
        195                 200                 205             


Pro Ala Gly Trp Glu Val Phe Asp Val Trp Gln Gly Leu Arg His Gln 
    210                 215                 220                 


Pro Trp Lys Gln Leu Cys Leu Glu Leu Arg Ala Ala Trp Gly Glu Leu 
225                 230                 235                 240 


Asp Ala Gly Glu Ala Glu Ala Arg Ala Arg Gly Pro Gln Gln Pro Pro 
                245                 250                 255     


Pro Pro Asp Leu Arg Ser Leu Gly Phe Gly Arg Arg Val Arg Pro Pro 
            260                 265                 270         


Gln Glu Arg Ala Leu Leu Val Val Phe Thr Arg Ser Gln Arg Lys Asn 
        275                 280                 285             


Leu Phe Ala Glu Met Arg Glu Gln Leu Gly Ser Ala Glu Ala Ala Gly 
    290                 295                 300                 


Pro Gly Ala Gly Ala Glu Gly Ser Trp Pro Pro Pro Ser Gly Ala Pro 
305                 310                 315                 320 


Asp Ala Arg Pro Trp Leu Pro Ser Pro Gly Arg Arg Arg Arg Arg Thr 
                325                 330                 335     


Ala Phe Ala Ser Arg His Gly Lys Arg His Gly Lys Lys Ser Arg Leu 
            340                 345                 350         


Arg Cys Ser Lys Lys Pro Leu His Val Asn Phe Lys Glu Leu Gly Trp 
        355                 360                 365             


Asp Asp Trp Ile Ile Ala Pro Leu Glu Tyr Glu Ala Tyr His Cys Glu 
    370                 375                 380                 


Gly Val Cys Asp Phe Pro Leu Arg Ser His Leu Glu Pro Thr Asn His 
385                 390                 395                 400 


Ala Ile Ile Gln Thr Leu Met Asn Ser Met Asp Pro Gly Ser Thr Pro 
                405                 410                 415     


Pro Ser Cys Cys Val Pro Thr Lys Leu Thr Pro Ile Ser Ile Leu Tyr 
            420                 425                 430         


Ile Asp Ala Gly Asn Asn Val Val Tyr Lys Gln Tyr Glu Asp Met Val 
        435                 440                 445             


Val Glu Ser Cys Gly Cys Arg 
    450                 455 


<210>  5858
<211>  353
<212>  PRT
<213>  Homo Sapiens

<400>  5858

Met Asp Thr Pro Arg Val Leu Leu Ser Ala Val Phe Leu Ile Ser Phe 
1               5                   10                  15      


Leu Trp Asp Leu Pro Gly Phe Gln Gln Ala Ser Ile Ser Ser Ser Ser 
            20                  25                  30          


Ser Ser Ala Glu Leu Gly Ser Thr Lys Gly Met Arg Ser Arg Lys Glu 
        35                  40                  45              


Gly Lys Met Gln Arg Ala Pro Arg Asp Ser Asp Ala Gly Arg Glu Gly 
    50                  55                  60                  


Gln Glu Pro Gln Pro Arg Pro Gln Asp Glu Pro Arg Ala Gln Gln Pro 
65                  70                  75                  80  


Arg Ala Gln Glu Pro Pro Gly Arg Gly Pro Arg Val Val Pro His Glu 
                85                  90                  95      


Tyr Met Leu Ser Ile Tyr Arg Thr Tyr Ser Ile Ala Glu Lys Leu Gly 
            100                 105                 110         


Ile Asn Ala Ser Phe Phe Gln Ser Ser Lys Ser Ala Asn Thr Ile Thr 
        115                 120                 125             


Ser Phe Val Asp Arg Gly Leu Asp Asp Leu Ser His Thr Pro Leu Arg 
    130                 135                 140                 


Arg Gln Lys Tyr Leu Phe Asp Val Ser Met Leu Ser Asp Lys Glu Glu 
145                 150                 155                 160 


Leu Val Gly Ala Glu Leu Arg Leu Phe Arg Gln Ala Pro Ser Ala Pro 
                165                 170                 175     


Trp Gly Pro Pro Ala Gly Pro Leu His Val Gln Leu Phe Pro Cys Leu 
            180                 185                 190         


Ser Pro Leu Leu Leu Asp Ala Arg Thr Leu Asp Pro Gln Gly Ala Pro 
        195                 200                 205             


Pro Ala Gly Trp Glu Val Phe Asp Val Trp Gln Gly Leu Arg His Gln 
    210                 215                 220                 


Pro Trp Lys Gln Leu Cys Leu Glu Leu Arg Ala Ala Trp Gly Glu Leu 
225                 230                 235                 240 


Asp Ala Gly Glu Ala Glu Ala Arg Ala Arg Gly Pro Gln Gln Pro Pro 
                245                 250                 255     


Pro Pro Asp Leu Arg Ser Leu Gly Phe Gly Arg Arg Val Arg Pro Pro 
            260                 265                 270         


Gln Glu Arg Ala Leu Leu Val Val Phe Thr Arg Ser Gln Arg Lys Asn 
        275                 280                 285             


Leu Phe Ala Ala Gly Val Arg Gly Leu Ser Leu Arg Gly Cys Met Arg 
    290                 295                 300                 


Leu Pro Ala Ala Leu Ala Pro Gly Ala His Gln Pro Arg His His Pro 
305                 310                 315                 320 


Asp Ala Asp Glu Leu His Gly Pro Arg Leu His Pro Ala Gln Leu Leu 
                325                 330                 335     


Arg Ala His Gln Ile Asp Ser His Gln His Ser Ile His Arg Arg Gly 
            340                 345                 350         


Gln 
    


<210>  5859
<211>  450
<212>  PRT
<213>  Homo Sapiens

<400>  5859

Met Asp Leu Ser Ala Ala Ala Ala Leu Cys Leu Trp Leu Leu Ser Ala 
1               5                   10                  15      


Cys Arg Pro Arg Asp Gly Leu Glu Ala Ala Ala Val Leu Arg Ala Ala 
            20                  25                  30          


Gly Ala Gly Pro Val Arg Ser Pro Gly Gly Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Gly Gly Arg Thr Leu Ala Gln Ala Ala Gly Ala Ala Ala Val Pro Ala 
    50                  55                  60                  


Ala Ala Val Pro Arg Ala Arg Ala Ala Arg Arg Ala Ala Gly Ser Gly 
65                  70                  75                  80  


Phe Arg Asn Gly Ser Val Val Pro His His Phe Met Met Ser Leu Tyr 
                85                  90                  95      


Arg Ser Leu Ala Gly Arg Ala Pro Ala Gly Ala Ala Ala Val Ser Ala 
            100                 105                 110         


Ser Gly His Gly Arg Ala Asp Thr Ile Thr Gly Phe Thr Asp Gln Ala 
        115                 120                 125             


Thr Gln Asp Glu Ser Ala Ala Glu Thr Gly Gln Ser Phe Leu Phe Asp 
    130                 135                 140                 


Val Ser Ser Leu Asn Asp Ala Asp Glu Val Val Gly Ala Glu Leu Arg 
145                 150                 155                 160 


Val Leu Arg Arg Gly Ser Pro Glu Ser Gly Pro Gly Ser Trp Thr Ser 
                165                 170                 175     


Pro Pro Leu Leu Leu Leu Ser Thr Cys Pro Gly Ala Ala Arg Ala Pro 
            180                 185                 190         


Arg Leu Leu Tyr Ser Arg Ala Ala Glu Pro Leu Val Gly Gln Arg Trp 
        195                 200                 205             


Glu Ala Phe Asp Val Ala Asp Ala Met Arg Arg His Arg Arg Glu Pro 
    210                 215                 220                 


Arg Pro Pro Arg Ala Phe Cys Leu Leu Leu Arg Ala Val Ala Gly Pro 
225                 230                 235                 240 


Val Pro Ser Pro Leu Ala Leu Arg Arg Leu Gly Phe Gly Trp Pro Gly 
                245                 250                 255     


Gly Gly Gly Ser Ala Ala Glu Glu Arg Ala Val Leu Val Val Ser Ser 
            260                 265                 270         


Arg Thr Gln Arg Lys Glu Ser Leu Phe Arg Glu Ile Arg Ala Gln Ala 
        275                 280                 285             


Arg Ala Leu Gly Ala Ala Leu Ala Ser Glu Pro Leu Pro Asp Pro Gly 
    290                 295                 300                 


Thr Gly Thr Ala Ser Pro Arg Ala Val Ile Gly Gly Arg Arg Arg Arg 
305                 310                 315                 320 


Arg Thr Ala Leu Ala Gly Thr Arg Thr Ala Gln Gly Ser Gly Gly Gly 
                325                 330                 335     


Ala Gly Arg Gly His Gly Arg Arg Gly Arg Ser Arg Cys Ser Arg Lys 
            340                 345                 350         


Pro Leu His Val Asp Phe Lys Glu Leu Gly Trp Asp Asp Trp Ile Ile 
        355                 360                 365             


Ala Pro Leu Asp Tyr Glu Ala Tyr His Cys Glu Gly Leu Cys Asp Phe 
    370                 375                 380                 


Pro Leu Arg Ser His Leu Glu Pro Thr Asn His Ala Ile Ile Gln Thr 
385                 390                 395                 400 


Leu Leu Asn Ser Met Ala Pro Asp Ala Ala Pro Ala Ser Cys Cys Val 
                405                 410                 415     


Pro Ala Arg Leu Ser Pro Ile Ser Ile Leu Tyr Ile Asp Ala Ala Asn 
            420                 425                 430         


Asn Val Val Tyr Lys Gln Tyr Glu Asp Met Val Val Glu Ala Cys Gly 
        435                 440                 445             


Cys Arg 
    450 


<210>  5860
<211>  454
<212>  PRT
<213>  Homo Sapiens

<400>  5860

Met Ala Arg Pro Asn Lys Phe Leu Leu Trp Phe Cys Cys Phe Ala Trp 
1               5                   10                  15      


Leu Cys Phe Pro Ile Ser Leu Gly Ser Gln Ala Ser Gly Gly Glu Ala 
            20                  25                  30          


Gln Ile Ala Ala Ser Ala Glu Leu Glu Ser Gly Ala Met Pro Trp Ser 
        35                  40                  45              


Leu Leu Gln His Ile Asp Glu Arg Asp Arg Ala Gly Leu Leu Pro Ala 
    50                  55                  60                  


Leu Phe Lys Val Leu Ser Val Gly Arg Gly Gly Ser Pro Arg Leu Gln 
65                  70                  75                  80  


Pro Asp Ser Arg Ala Leu His Tyr Met Lys Lys Leu Tyr Lys Thr Tyr 
                85                  90                  95      


Ala Thr Lys Glu Gly Ile Pro Lys Ser Asn Arg Ser His Leu Tyr Asn 
            100                 105                 110         


Thr Val Arg Leu Phe Thr Pro Cys Thr Arg His Lys Gln Ala Pro Gly 
        115                 120                 125             


Asp Gln Val Thr Gly Ile Leu Pro Ser Val Glu Leu Leu Phe Asn Leu 
    130                 135                 140                 


Asp Arg Ile Thr Thr Val Glu His Leu Leu Lys Ser Val Leu Leu Tyr 
145                 150                 155                 160 


Asn Ile Asn Asn Ser Val Ser Phe Ser Ser Ala Val Lys Cys Val Cys 
                165                 170                 175     


Asn Leu Met Ile Lys Glu Pro Lys Ser Ser Ser Arg Thr Leu Gly Arg 
            180                 185                 190         


Ala Pro Tyr Ser Phe Thr Phe Asn Ser Gln Phe Glu Phe Gly Lys Lys 
        195                 200                 205             


His Lys Trp Ile Gln Ile Asp Val Thr Ser Leu Leu Gln Pro Leu Val 
    210                 215                 220                 


Ala Ser Asn Lys Arg Ser Ile His Met Ser Ile Asn Phe Thr Cys Met 
225                 230                 235                 240 


Lys Asp Gln Leu Glu His Pro Ser Ala Gln Asn Gly Leu Phe Asn Met 
                245                 250                 255     


Thr Leu Val Ser Pro Ser Leu Ile Leu Tyr Leu Asn Asp Thr Ser Ala 
            260                 265                 270         


Gln Ala Tyr His Ser Trp Tyr Ser Leu His Tyr Lys Arg Arg Pro Ser 
        275                 280                 285             


Gln Gly Pro Asp Gln Glu Arg Ser Leu Ser Ala Tyr Pro Val Gly Glu 
    290                 295                 300                 


Glu Ala Ala Glu Asp Gly Arg Ser Ser His His Arg His Arg Arg Gly 
305                 310                 315                 320 


Gln Glu Thr Val Ser Ser Glu Leu Lys Lys Pro Leu Gly Pro Ala Ser 
                325                 330                 335     


Phe Asn Leu Ser Glu Tyr Phe Arg Gln Phe Leu Leu Pro Gln Asn Glu 
            340                 345                 350         


Cys Glu Leu His Asp Phe Arg Leu Ser Phe Ser Gln Leu Lys Trp Asp 
        355                 360                 365             


Asn Trp Ile Val Ala Pro His Arg Tyr Asn Pro Arg Tyr Cys Lys Gly 
    370                 375                 380                 


Asp Cys Pro Arg Ala Val Gly His Arg Tyr Gly Ser Pro Val His Thr 
385                 390                 395                 400 


Met Val Gln Asn Ile Ile Tyr Glu Lys Leu Asp Ser Ser Val Pro Arg 
                405                 410                 415     


Pro Ser Cys Val Pro Ala Lys Tyr Ser Pro Leu Ser Val Leu Thr Ile 
            420                 425                 430         


Glu Pro Asp Gly Ser Ile Ala Tyr Lys Glu Tyr Glu Asp Met Ile Ala 
        435                 440                 445             


Thr Lys Cys Thr Cys Arg 
    450                 


<210>  5861
<211>  366
<212>  PRT
<213>  Homo Sapiens

<400>  5861

Met Lys Lys Leu Tyr Lys Thr Tyr Ala Thr Lys Glu Gly Ile Pro Lys 
1               5                   10                  15      


Ser Asn Arg Ser His Leu Tyr Asn Thr Val Arg Leu Phe Thr Pro Cys 
            20                  25                  30          


Thr Arg His Lys Gln Ala Pro Gly Asp Gln Val Thr Gly Ile Leu Pro 
        35                  40                  45              


Ser Val Glu Leu Leu Phe Asn Leu Asp Arg Ile Thr Thr Val Glu His 
    50                  55                  60                  


Leu Leu Lys Ser Val Leu Leu Tyr Asn Ile Asn Asn Ser Val Ser Phe 
65                  70                  75                  80  


Ser Ser Ala Val Lys Cys Val Cys Asn Leu Met Ile Lys Glu Pro Lys 
                85                  90                  95      


Ser Ser Ser Arg Thr Leu Gly Arg Ala Pro Tyr Ser Phe Thr Phe Asn 
            100                 105                 110         


Ser Gln Phe Glu Phe Gly Lys Lys His Lys Trp Ile Gln Ile Asp Val 
        115                 120                 125             


Thr Ser Leu Leu Gln Pro Leu Val Ala Ser Asn Lys Arg Ser Ile His 
    130                 135                 140                 


Met Ser Ile Asn Phe Thr Cys Met Lys Asp Gln Leu Glu His Pro Ser 
145                 150                 155                 160 


Ala Gln Asn Gly Leu Phe Asn Met Thr Leu Val Ser Pro Ser Leu Ile 
                165                 170                 175     


Leu Tyr Leu Asn Asp Thr Ser Ala Gln Ala Tyr His Ser Trp Tyr Ser 
            180                 185                 190         


Leu His Tyr Lys Arg Arg Pro Ser Gln Gly Pro Asp Gln Glu Arg Ser 
        195                 200                 205             


Leu Ser Ala Tyr Pro Val Gly Glu Glu Ala Ala Glu Asp Gly Arg Ser 
    210                 215                 220                 


Ser His His Arg His Arg Arg Gly Gln Glu Thr Val Ser Ser Glu Leu 
225                 230                 235                 240 


Lys Lys Pro Leu Gly Pro Ala Ser Phe Asn Leu Ser Glu Tyr Phe Arg 
                245                 250                 255     


Gln Phe Leu Leu Pro Gln Asn Glu Cys Glu Leu His Asp Phe Arg Leu 
            260                 265                 270         


Ser Phe Ser Gln Leu Lys Trp Asp Asn Trp Ile Val Ala Pro His Arg 
        275                 280                 285             


Tyr Asn Pro Arg Tyr Cys Lys Gly Asp Cys Pro Arg Ala Val Gly His 
    290                 295                 300                 


Arg Tyr Gly Ser Pro Val His Thr Met Val Gln Asn Ile Ile Tyr Glu 
305                 310                 315                 320 


Lys Leu Asp Ser Ser Val Pro Arg Pro Ser Cys Val Pro Ala Lys Tyr 
                325                 330                 335     


Ser Pro Leu Ser Val Leu Thr Ile Glu Pro Asp Gly Ser Ile Ala Tyr 
            340                 345                 350         


Lys Glu Tyr Glu Asp Met Ile Ala Thr Lys Cys Thr Cys Arg 
        355                 360                 365     


<210>  5862
<211>  366
<212>  PRT
<213>  Homo Sapiens

<400>  5862

Met Lys Lys Leu Tyr Lys Thr Tyr Ala Thr Lys Glu Gly Ile Pro Lys 
1               5                   10                  15      


Ser Asn Arg Ser His Leu Tyr Asn Thr Val Arg Leu Phe Thr Pro Cys 
            20                  25                  30          


Thr Arg His Lys Gln Ala Pro Gly Asp Gln Val Thr Gly Ile Leu Pro 
        35                  40                  45              


Ser Val Glu Leu Leu Phe Asn Leu Asp Arg Ile Thr Thr Val Glu His 
    50                  55                  60                  


Leu Leu Lys Ser Val Leu Leu Tyr Asn Ile Asn Asn Ser Val Ser Phe 
65                  70                  75                  80  


Ser Ser Ala Val Lys Cys Val Cys Asn Leu Met Ile Lys Glu Pro Lys 
                85                  90                  95      


Ser Ser Ser Arg Thr Leu Gly Arg Ala Pro Tyr Ser Phe Thr Phe Asn 
            100                 105                 110         


Ser Gln Phe Glu Phe Gly Lys Lys His Lys Trp Ile Gln Ile Asp Val 
        115                 120                 125             


Thr Ser Leu Leu Gln Pro Leu Val Ala Ser Asn Lys Arg Ser Ile His 
    130                 135                 140                 


Met Ser Ile Asn Phe Thr Cys Met Lys Asp Gln Leu Glu His Pro Ser 
145                 150                 155                 160 


Ala Gln Asn Gly Leu Phe Asn Met Thr Leu Val Ser Pro Ser Leu Ile 
                165                 170                 175     


Leu Tyr Leu Asn Asp Thr Ser Ala Gln Ala Tyr His Ser Trp Tyr Ser 
            180                 185                 190         


Leu His Tyr Lys Arg Arg Pro Ser Gln Gly Pro Asp Gln Glu Arg Ser 
        195                 200                 205             


Leu Ser Ala Tyr Pro Val Gly Glu Glu Ala Ala Glu Asp Gly Arg Ser 
    210                 215                 220                 


Ser His His Arg His Arg Arg Gly Gln Glu Thr Val Ser Ser Glu Leu 
225                 230                 235                 240 


Lys Lys Pro Leu Gly Pro Ala Ser Phe Asn Leu Ser Glu Tyr Phe Arg 
                245                 250                 255     


Gln Phe Leu Leu Pro Gln Asn Glu Cys Glu Leu His Asp Phe Arg Leu 
            260                 265                 270         


Ser Phe Ser Gln Leu Lys Trp Asp Asn Trp Ile Val Ala Pro His Arg 
        275                 280                 285             


Tyr Asn Pro Arg Tyr Cys Lys Gly Asp Cys Pro Arg Ala Val Gly His 
    290                 295                 300                 


Arg Tyr Gly Ser Pro Val His Thr Met Val Gln Asn Ile Ile Tyr Glu 
305                 310                 315                 320 


Lys Leu Asp Ser Ser Val Pro Arg Pro Ser Cys Val Pro Ala Lys Tyr 
                325                 330                 335     


Ser Pro Leu Ser Val Leu Thr Ile Glu Pro Asp Gly Ser Ile Ala Tyr 
            340                 345                 350         


Lys Glu Tyr Glu Asp Met Ile Ala Thr Lys Cys Thr Cys Arg 
        355                 360                 365     


<210>  5863
<211>  366
<212>  PRT
<213>  Homo Sapiens

<400>  5863

Met Lys Lys Leu Tyr Lys Thr Tyr Ala Thr Lys Glu Gly Ile Pro Lys 
1               5                   10                  15      


Ser Asn Arg Ser His Leu Tyr Asn Thr Val Arg Leu Phe Thr Pro Cys 
            20                  25                  30          


Thr Arg His Lys Gln Ala Pro Gly Asp Gln Val Thr Gly Ile Leu Pro 
        35                  40                  45              


Ser Val Glu Leu Leu Phe Asn Leu Asp Arg Ile Thr Thr Val Glu His 
    50                  55                  60                  


Leu Leu Lys Ser Val Leu Leu Tyr Asn Ile Asn Asn Ser Val Ser Phe 
65                  70                  75                  80  


Ser Ser Ala Val Lys Cys Val Cys Asn Leu Met Ile Lys Glu Pro Lys 
                85                  90                  95      


Ser Ser Ser Arg Thr Leu Gly Arg Ala Pro Tyr Ser Phe Thr Phe Asn 
            100                 105                 110         


Ser Gln Phe Glu Phe Gly Lys Lys His Lys Trp Ile Gln Ile Asp Val 
        115                 120                 125             


Thr Ser Leu Leu Gln Pro Leu Val Ala Ser Asn Lys Arg Ser Ile His 
    130                 135                 140                 


Met Ser Ile Asn Phe Thr Cys Met Lys Asp Gln Leu Glu His Pro Ser 
145                 150                 155                 160 


Ala Gln Asn Gly Leu Phe Asn Met Thr Leu Val Ser Pro Ser Leu Ile 
                165                 170                 175     


Leu Tyr Leu Asn Asp Thr Ser Ala Gln Ala Tyr His Ser Trp Tyr Ser 
            180                 185                 190         


Leu His Tyr Lys Arg Arg Pro Ser Gln Gly Pro Asp Gln Glu Arg Ser 
        195                 200                 205             


Leu Ser Ala Tyr Pro Val Gly Glu Glu Ala Ala Glu Asp Gly Arg Ser 
    210                 215                 220                 


Ser His His Arg His Arg Arg Gly Gln Glu Thr Val Ser Ser Glu Leu 
225                 230                 235                 240 


Lys Lys Pro Leu Gly Pro Ala Ser Phe Asn Leu Ser Glu Tyr Phe Arg 
                245                 250                 255     


Gln Phe Leu Leu Pro Gln Asn Glu Cys Glu Leu His Asp Phe Arg Leu 
            260                 265                 270         


Ser Phe Ser Gln Leu Lys Trp Asp Asn Trp Ile Val Ala Pro His Arg 
        275                 280                 285             


Tyr Asn Pro Arg Tyr Cys Lys Gly Asp Cys Pro Arg Ala Val Gly His 
    290                 295                 300                 


Arg Tyr Gly Ser Pro Val His Thr Met Val Gln Asn Ile Ile Tyr Glu 
305                 310                 315                 320 


Lys Leu Asp Ser Ser Val Pro Arg Pro Ser Cys Val Pro Ala Lys Tyr 
                325                 330                 335     


Ser Pro Leu Ser Val Leu Thr Ile Glu Pro Asp Gly Ser Ile Ala Tyr 
            340                 345                 350         


Lys Glu Tyr Glu Asp Met Ile Ala Thr Lys Cys Thr Cys Arg 
        355                 360                 365     


<210>  5864
<211>  366
<212>  PRT
<213>  Homo Sapiens

<400>  5864

Met Lys Lys Leu Tyr Lys Thr Tyr Ala Thr Lys Glu Gly Ile Pro Lys 
1               5                   10                  15      


Ser Asn Arg Ser His Leu Tyr Asn Thr Val Arg Leu Phe Thr Pro Cys 
            20                  25                  30          


Thr Arg His Lys Gln Ala Pro Gly Asp Gln Val Thr Gly Ile Leu Pro 
        35                  40                  45              


Ser Val Glu Leu Leu Phe Asn Leu Asp Arg Ile Thr Thr Val Glu His 
    50                  55                  60                  


Leu Leu Lys Ser Val Leu Leu Tyr Asn Ile Asn Asn Ser Val Ser Phe 
65                  70                  75                  80  


Ser Ser Ala Val Lys Cys Val Cys Asn Leu Met Ile Lys Glu Pro Lys 
                85                  90                  95      


Ser Ser Ser Arg Thr Leu Gly Arg Ala Pro Tyr Ser Phe Thr Phe Asn 
            100                 105                 110         


Ser Gln Phe Glu Phe Gly Lys Lys His Lys Trp Ile Gln Ile Asp Val 
        115                 120                 125             


Thr Ser Leu Leu Gln Pro Leu Val Ala Ser Asn Lys Arg Ser Ile His 
    130                 135                 140                 


Met Ser Ile Asn Phe Thr Cys Met Lys Asp Gln Leu Glu His Pro Ser 
145                 150                 155                 160 


Ala Gln Asn Gly Leu Phe Asn Met Thr Leu Val Ser Pro Ser Leu Ile 
                165                 170                 175     


Leu Tyr Leu Asn Asp Thr Ser Ala Gln Ala Tyr His Ser Trp Tyr Ser 
            180                 185                 190         


Leu His Tyr Lys Arg Arg Pro Ser Gln Gly Pro Asp Gln Glu Arg Ser 
        195                 200                 205             


Leu Ser Ala Tyr Pro Val Gly Glu Glu Ala Ala Glu Asp Gly Arg Ser 
    210                 215                 220                 


Ser His His Arg His Arg Arg Gly Gln Glu Thr Val Ser Ser Glu Leu 
225                 230                 235                 240 


Lys Lys Pro Leu Gly Pro Ala Ser Phe Asn Leu Ser Glu Tyr Phe Arg 
                245                 250                 255     


Gln Phe Leu Leu Pro Gln Asn Glu Cys Glu Leu His Asp Phe Arg Leu 
            260                 265                 270         


Ser Phe Ser Gln Leu Lys Trp Asp Asn Trp Ile Val Ala Pro His Arg 
        275                 280                 285             


Tyr Asn Pro Arg Tyr Cys Lys Gly Asp Cys Pro Arg Ala Val Gly His 
    290                 295                 300                 


Arg Tyr Gly Ser Pro Val His Thr Met Val Gln Asn Ile Ile Tyr Glu 
305                 310                 315                 320 


Lys Leu Asp Ser Ser Val Pro Arg Pro Ser Cys Val Pro Ala Lys Tyr 
                325                 330                 335     


Ser Pro Leu Ser Val Leu Thr Ile Glu Pro Asp Gly Ser Ile Ala Tyr 
            340                 345                 350         


Lys Glu Tyr Glu Asp Met Ile Ala Thr Lys Cys Thr Cys Arg 
        355                 360                 365     


<210>  5865
<211>  61
<212>  PRT
<213>  Homo Sapiens

<400>  5865

Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His Thr 
1               5                   10                  15      


Ala Ser Ala Phe Pro Leu Pro Ala Ala Asn Met Pro Glu Asp Tyr Pro 
            20                  25                  30          


Asp Gln Phe Asp Asp Val Met Asp Phe Ile Gln Ala Thr Ile Lys Arg 
        35                  40                  45              


Leu Lys Arg Ser Pro Asp Lys Gln Met Ala Val Leu Pro 
    50                  55                  60      


<210>  5866
<211>  61
<212>  PRT
<213>  Homo Sapiens

<400>  5866

Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His Thr 
1               5                   10                  15      


Ala Ser Ala Phe Pro Leu Pro Ala Ala Asn Met Pro Glu Asp Tyr Pro 
            20                  25                  30          


Asp Gln Phe Asp Asp Val Met Asp Phe Ile Gln Ala Thr Ile Lys Arg 
        35                  40                  45              


Leu Lys Arg Ser Pro Asp Lys Gln Met Ala Val Leu Pro 
    50                  55                  60      


<210>  5867
<211>  185
<212>  PRT
<213>  Homo Sapiens

<400>  5867

Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His Thr 
1               5                   10                  15      


Ala Ser Ala Phe Pro Leu Pro Ala Ala Asn Met Pro Glu Asp Tyr Pro 
            20                  25                  30          


Asp Gln Phe Asp Asp Val Met Asp Phe Ile Gln Ala Thr Ile Lys Arg 
        35                  40                  45              


Leu Lys Arg Ser Pro Asp Lys Gln Met Ala Val Leu Pro Arg Arg Glu 
    50                  55                  60                  


Arg Asn Arg Gln Ala Ala Ala Ala Asn Pro Glu Asn Ser Arg Gly Lys 
65                  70                  75                  80  


Gly Arg Arg Gly Gln Arg Gly Lys Asn Arg Gly Cys Val Leu Thr Ala 
                85                  90                  95      


Ile His Leu Asn Val Thr Asp Leu Gly Leu Gly Tyr Glu Thr Lys Glu 
            100                 105                 110         


Glu Leu Ile Phe Arg Tyr Cys Ser Gly Ser Cys Asp Ala Ala Glu Thr 
        115                 120                 125             


Thr Tyr Asp Lys Ile Leu Lys Asn Leu Ser Arg Asn Arg Arg Leu Val 
    130                 135                 140                 


Ser Asp Lys Val Gly Gln Ala Cys Cys Arg Pro Ile Ala Phe Asp Asp 
145                 150                 155                 160 


Asp Leu Ser Phe Leu Asp Asp Asn Leu Val Tyr His Ile Leu Arg Lys 
                165                 170                 175     


His Ser Ala Lys Arg Cys Gly Cys Ile 
            180                 185 


<210>  5868
<211>  185
<212>  PRT
<213>  Homo Sapiens

<400>  5868

Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His Thr 
1               5                   10                  15      


Ala Ser Ala Phe Pro Leu Pro Ala Ala Asn Met Pro Glu Asp Tyr Pro 
            20                  25                  30          


Asp Gln Phe Asp Asp Val Met Asp Phe Ile Gln Ala Thr Ile Lys Arg 
        35                  40                  45              


Leu Lys Arg Ser Pro Asp Lys Gln Met Ala Val Leu Pro Arg Arg Glu 
    50                  55                  60                  


Arg Asn Arg Gln Ala Ala Ala Ala Asn Pro Glu Asn Ser Arg Gly Lys 
65                  70                  75                  80  


Gly Arg Arg Gly Gln Arg Gly Lys Asn Arg Gly Cys Val Leu Thr Ala 
                85                  90                  95      


Ile His Leu Asn Val Thr Asp Leu Gly Leu Gly Tyr Glu Thr Lys Glu 
            100                 105                 110         


Glu Leu Ile Phe Arg Tyr Cys Ser Gly Ser Cys Asp Ala Ala Glu Thr 
        115                 120                 125             


Thr Tyr Asp Lys Ile Leu Lys Asn Leu Ser Arg Asn Arg Arg Leu Val 
    130                 135                 140                 


Ser Asp Lys Val Gly Gln Ala Cys Cys Arg Pro Ile Ala Phe Asp Asp 
145                 150                 155                 160 


Asp Leu Ser Phe Leu Asp Asp Asn Leu Val Tyr His Ile Leu Arg Lys 
                165                 170                 175     


His Ser Ala Lys Arg Cys Gly Cys Ile 
            180                 185 


<210>  5869
<211>  211
<212>  PRT
<213>  Homo Sapiens

<400>  5869

Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His Thr 
1               5                   10                  15      


Ala Ser Ala Phe Pro Leu Pro Ala Gly Lys Arg Pro Pro Glu Ala Pro 
            20                  25                  30          


Ala Glu Asp Arg Ser Leu Gly Arg Arg Arg Ala Pro Phe Ala Leu Ser 
        35                  40                  45              


Ser Asp Ser Asn Met Pro Glu Asp Tyr Pro Asp Gln Phe Asp Asp Val 
    50                  55                  60                  


Met Asp Phe Ile Gln Ala Thr Ile Lys Arg Leu Lys Arg Ser Pro Asp 
65                  70                  75                  80  


Lys Gln Met Ala Val Leu Pro Arg Arg Glu Arg Asn Arg Gln Ala Ala 
                85                  90                  95      


Ala Ala Asn Pro Glu Asn Ser Arg Gly Lys Gly Arg Arg Gly Gln Arg 
            100                 105                 110         


Gly Lys Asn Arg Gly Cys Val Leu Thr Ala Ile His Leu Asn Val Thr 
        115                 120                 125             


Asp Leu Gly Leu Gly Tyr Glu Thr Lys Glu Glu Leu Ile Phe Arg Tyr 
    130                 135                 140                 


Cys Ser Gly Ser Cys Asp Ala Ala Glu Thr Thr Tyr Asp Lys Ile Leu 
145                 150                 155                 160 


Lys Asn Leu Ser Arg Asn Arg Arg Leu Val Ser Asp Lys Val Gly Gln 
                165                 170                 175     


Ala Cys Cys Arg Pro Ile Ala Phe Asp Asp Asp Leu Ser Phe Leu Asp 
            180                 185                 190         


Asp Asn Leu Val Tyr His Ile Leu Arg Lys His Ser Ala Lys Arg Cys 
        195                 200                 205             


Gly Cys Ile 
    210     


<210>  5870
<211>  159
<212>  PRT
<213>  Homo Sapiens

<400>  5870

Met Pro Glu Asp Tyr Pro Asp Gln Phe Asp Asp Val Met Asp Phe Ile 
1               5                   10                  15      


Gln Ala Thr Ile Lys Arg Leu Lys Arg Ser Pro Asp Lys Gln Met Ala 
            20                  25                  30          


Val Leu Pro Arg Arg Glu Arg Asn Arg Gln Ala Ala Ala Ala Asn Pro 
        35                  40                  45              


Glu Asn Ser Arg Gly Lys Gly Arg Arg Gly Gln Arg Gly Lys Asn Arg 
    50                  55                  60                  


Gly Cys Val Leu Thr Ala Ile His Leu Asn Val Thr Asp Leu Gly Leu 
65                  70                  75                  80  


Gly Tyr Glu Thr Lys Glu Glu Leu Ile Phe Arg Tyr Cys Ser Gly Ser 
                85                  90                  95      


Cys Asp Ala Ala Glu Thr Thr Tyr Asp Lys Ile Leu Lys Asn Leu Ser 
            100                 105                 110         


Arg Asn Arg Arg Leu Val Ser Asp Lys Val Gly Gln Ala Cys Cys Arg 
        115                 120                 125             


Pro Ile Ala Phe Asp Asp Asp Leu Ser Phe Leu Asp Asp Asn Leu Val 
    130                 135                 140                 


Tyr His Ile Leu Arg Lys His Ser Ala Lys Arg Cys Gly Cys Ile 
145                 150                 155                 


<210>  5871
<211>  202
<212>  PRT
<213>  Homo Sapiens

<400>  5871

Met Gln Ser Leu Pro Asn Ser Asn Gly Ala Ala Ala Gly Arg Asp Phe 
1               5                   10                  15      


Lys Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His 
            20                  25                  30          


Thr Ala Ser Ala Phe Pro Leu Pro Ala Ala Asn Met Pro Glu Asp Tyr 
        35                  40                  45              


Pro Asp Gln Phe Asp Asp Val Met Asp Phe Ile Gln Ala Thr Ile Lys 
    50                  55                  60                  


Arg Leu Lys Arg Ser Pro Asp Lys Gln Met Ala Val Leu Pro Arg Arg 
65                  70                  75                  80  


Glu Arg Asn Arg Gln Ala Ala Ala Ala Asn Pro Glu Asn Ser Arg Gly 
                85                  90                  95      


Lys Gly Arg Arg Gly Gln Arg Gly Lys Asn Arg Gly Cys Val Leu Thr 
            100                 105                 110         


Ala Ile His Leu Asn Val Thr Asp Leu Gly Leu Gly Tyr Glu Thr Lys 
        115                 120                 125             


Glu Glu Leu Ile Phe Arg Tyr Cys Ser Gly Ser Cys Asp Ala Ala Glu 
    130                 135                 140                 


Thr Thr Tyr Asp Lys Ile Leu Lys Asn Leu Ser Arg Asn Arg Arg Leu 
145                 150                 155                 160 


Val Ser Asp Lys Val Gly Gln Ala Cys Cys Arg Pro Ile Ala Phe Asp 
                165                 170                 175     


Asp Asp Leu Ser Phe Leu Asp Asp Asn Leu Val Tyr His Ile Leu Arg 
            180                 185                 190         


Lys His Ser Ala Lys Arg Cys Gly Cys Ile 
        195                 200         


<210>  5872
<211>  228
<212>  PRT
<213>  Homo Sapiens

<400>  5872

Met Gln Ser Leu Pro Asn Ser Asn Gly Ala Ala Ala Gly Arg Asp Phe 
1               5                   10                  15      


Lys Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His 
            20                  25                  30          


Thr Ala Ser Ala Phe Pro Leu Pro Ala Gly Lys Arg Pro Pro Glu Ala 
        35                  40                  45              


Pro Ala Glu Asp Arg Ser Leu Gly Arg Arg Arg Ala Pro Phe Ala Leu 
    50                  55                  60                  


Ser Ser Asp Ser Asn Met Pro Glu Asp Tyr Pro Asp Gln Phe Asp Asp 
65                  70                  75                  80  


Val Met Asp Phe Ile Gln Ala Thr Ile Lys Arg Leu Lys Arg Ser Pro 
                85                  90                  95      


Asp Lys Gln Met Ala Val Leu Pro Arg Arg Glu Arg Asn Arg Gln Ala 
            100                 105                 110         


Ala Ala Ala Asn Pro Glu Asn Ser Arg Gly Lys Gly Arg Arg Gly Gln 
        115                 120                 125             


Arg Gly Lys Asn Arg Gly Cys Val Leu Thr Ala Ile His Leu Asn Val 
    130                 135                 140                 


Thr Asp Leu Gly Leu Gly Tyr Glu Thr Lys Glu Glu Leu Ile Phe Arg 
145                 150                 155                 160 


Tyr Cys Ser Gly Ser Cys Asp Ala Ala Glu Thr Thr Tyr Asp Lys Ile 
                165                 170                 175     


Leu Lys Asn Leu Ser Arg Asn Arg Arg Leu Val Ser Asp Lys Val Gly 
            180                 185                 190         


Gln Ala Cys Cys Arg Pro Ile Ala Phe Asp Asp Asp Leu Ser Phe Leu 
        195                 200                 205             


Asp Asp Asn Leu Val Tyr His Ile Leu Arg Lys His Ser Ala Lys Arg 
    210                 215                 220                 


Cys Gly Cys Ile 
225             


<210>  5873
<211>  90
<212>  PRT
<213>  Homo Sapiens

<400>  5873

Met Lys Met Leu Pro Gly Val Gly Val Phe Gly Thr Gly Ser Ser Ala 
1               5                   10                  15      


Arg Val Leu Val Pro Leu Leu Arg Ala Glu Gly Phe Thr Val Glu Ala 
            20                  25                  30          


Leu Trp Gly Lys Thr Glu Glu Glu Ala Lys Gln Leu Ala Glu Glu Met 
        35                  40                  45              


Asn Ile Ala Phe Tyr Thr Ser Arg Thr Asp Asp Ile Leu Leu His Gln 
    50                  55                  60                  


Asp Val Asp Leu Val Cys Ile Ser Ile Pro Pro Pro Leu Thr Arg Gln 
65                  70                  75                  80  


Ile Ser Val Lys Ala Leu Glu Ser Ser Leu 
                85                  90  


<210>  5874
<211>  385
<212>  PRT
<213>  Homo Sapiens

<400>  5874

Met Lys Met Leu Pro Gly Val Gly Val Phe Gly Thr Gly Ser Ser Ala 
1               5                   10                  15      


Arg Val Leu Val Pro Leu Leu Arg Ala Glu Gly Phe Thr Val Glu Ala 
            20                  25                  30          


Leu Trp Gly Lys Thr Glu Glu Glu Ala Lys Gln Leu Ala Glu Glu Met 
        35                  40                  45              


Asn Ile Ala Phe Tyr Thr Ser Arg Thr Asp Asp Ile Leu Leu His Gln 
    50                  55                  60                  


Asp Val Asp Leu Val Cys Ile Ser Ile Pro Pro Pro Leu Thr Arg Gln 
65                  70                  75                  80  


Ile Ser Val Lys Ala Leu Gly Ile Gly Lys Asn Val Val Cys Glu Lys 
                85                  90                  95      


Ala Ala Thr Ser Val Asp Ala Phe Arg Met Val Thr Ala Ser Arg Tyr 
            100                 105                 110         


Tyr Pro Gln Leu Met Ser Leu Val Gly Asn Val Leu Arg Phe Leu Pro 
        115                 120                 125             


Ala Phe Val Arg Met Lys Gln Leu Ile Ser Glu His Tyr Val Gly Ala 
    130                 135                 140                 


Val Met Ile Cys Asp Ala Arg Ile Tyr Ser Gly Ser Leu Leu Ser Pro 
145                 150                 155                 160 


Ser Tyr Gly Trp Ile Cys Asp Glu Leu Met Gly Gly Gly Gly Leu His 
                165                 170                 175     


Thr Met Gly Thr Tyr Ile Val Asp Leu Leu Thr His Leu Thr Gly Arg 
            180                 185                 190         


Arg Ala Glu Lys Val His Gly Leu Leu Lys Thr Phe Val Arg Gln Asn 
        195                 200                 205             


Ala Ala Ile Arg Gly Ile Arg His Val Thr Ser Asp Asp Phe Cys Phe 
    210                 215                 220                 


Phe Gln Met Leu Met Gly Gly Gly Val Cys Ser Thr Val Thr Leu Asn 
225                 230                 235                 240 


Phe Asn Met Pro Gly Ala Phe Val His Glu Val Met Val Val Gly Ser 
                245                 250                 255     


Ala Gly Arg Leu Val Ala Arg Gly Ala Asp Leu Tyr Gly Gln Lys Asn 
            260                 265                 270         


Ser Ala Thr Gln Glu Glu Leu Leu Leu Arg Asp Ser Leu Ala Val Gly 
        275                 280                 285             


Ala Gly Leu Pro Glu Gln Gly Pro Gln Asp Val Pro Leu Leu Tyr Leu 
    290                 295                 300                 


Lys Gly Met Val Tyr Met Val Gln Ala Leu Arg Gln Ser Phe Gln Gly 
305                 310                 315                 320 


Gln Gly Asp Arg Arg Thr Trp Asp Arg Thr Pro Val Ser Met Ala Ala 
                325                 330                 335     


Ser Phe Glu Asp Gly Leu Tyr Met Gln Ser Val Val Asp Ala Ile Lys 
            340                 345                 350         


Arg Ser Ser Arg Ser Gly Glu Trp Glu Ala Val Glu Val Leu Thr Glu 
        355                 360                 365             


Glu Pro Asp Thr Asn Gln Asn Leu Cys Glu Ala Leu Gln Arg Asn Asn 
    370                 375                 380                 


Leu 
385 


<210>  5875
<211>  112
<212>  PRT
<213>  Homo Sapiens

<400>  5875

Met Lys Met Leu Pro Gly Val Gly Val Phe Gly Thr Gly Ser Ser Ala 
1               5                   10                  15      


Arg Val Leu Val Pro Leu Leu Arg Ala Glu Gly Phe Thr Val Glu Ala 
            20                  25                  30          


Leu Trp Gly Lys Thr Glu Glu Glu Ala Lys Gln Leu Ala Glu Glu Met 
        35                  40                  45              


Asn Ile Ala Phe Tyr Thr Ser Arg Thr Asp Asp Ile Leu Leu His Gln 
    50                  55                  60                  


Asp Val Asp Leu Val Cys Ile Ser Ile Pro Pro Pro Leu Thr Arg Gln 
65                  70                  75                  80  


Ile Ser Val Lys Ala Leu Gly Thr Pro Gly Arg Pro Gln Gln Gly Gln 
                85                  90                  95      


Ile Met Ser Leu Pro Leu Gly Ser Pro Leu Arg Val Thr Pro Leu Leu 
            100                 105                 110         


<210>  5876
<211>  112
<212>  PRT
<213>  Homo Sapiens

<400>  5876

Met Lys Met Leu Pro Gly Val Gly Val Phe Gly Thr Gly Ser Ser Ala 
1               5                   10                  15      


Arg Val Leu Val Pro Leu Leu Arg Ala Glu Gly Phe Thr Val Glu Ala 
            20                  25                  30          


Leu Trp Gly Lys Thr Glu Glu Glu Ala Lys Gln Leu Ala Glu Glu Met 
        35                  40                  45              


Asn Ile Ala Phe Tyr Thr Ser Arg Thr Asp Asp Ile Leu Leu His Gln 
    50                  55                  60                  


Asp Val Asp Leu Val Cys Ile Ser Ile Pro Pro Pro Leu Thr Arg Gln 
65                  70                  75                  80  


Ile Ser Val Lys Ala Leu Gly Thr Pro Gly Arg Pro Gln Gln Gly Gln 
                85                  90                  95      


Ile Met Ser Leu Pro Leu Gly Ser Pro Leu Arg Val Thr Pro Leu Leu 
            100                 105                 110         


<210>  5877
<211>  88
<212>  PRT
<213>  Homo Sapiens

<400>  5877

Met Lys Met Leu Pro Gly Val Gly Val Phe Gly Thr Gly Ser Ser Ala 
1               5                   10                  15      


Arg Val Leu Val Pro Leu Leu Arg Ala Glu Gly Phe Thr Val Glu Ala 
            20                  25                  30          


Leu Trp Gly Lys Thr Glu Glu Glu Ala Lys Gln Leu Ala Glu Glu Met 
        35                  40                  45              


Asn Ile Ala Phe Tyr Thr Ser Arg Thr Asp Asp Ile Leu Leu His Gln 
    50                  55                  60                  


Asp Val Asp Leu Val Leu Gly Arg Met Trp Phe Ala Arg Arg Gln Gln 
65                  70                  75                  80  


His Arg Trp Met Pro Ser Gly Trp 
                85              


<210>  5878
<211>  103
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5878

Xaa Lys Thr Glu Glu Glu Ala Lys Gln Leu Ala Glu Glu Met Asn Ile 
1               5                   10                  15      


Ala Phe Tyr Thr Ser Arg Thr Asp Asp Ile Leu Leu His Gln Asp Val 
            20                  25                  30          


Asp Leu Val Cys Ile Ser Ile Pro Pro Pro Leu Thr Arg Gln Ile Ser 
        35                  40                  45              


Val Lys Ala Leu Gly Ser Thr Cys Gly Val Pro Glu Trp Ser Leu Asp 
    50                  55                  60                  


Gly Cys Gly Gly Glu Ala Gln Val His Thr Leu Pro Arg Trp Ala Ser 
65                  70                  75                  80  


Thr Arg Arg Val Leu Gly Arg Met Trp Phe Ala Arg Arg Gln Gln His 
                85                  90                  95      


Arg Trp Met Pro Ser Gly Trp 
            100             


<210>  5879
<211>  682
<212>  PRT
<213>  Homo Sapiens

<400>  5879

Met Cys Gly Ile Phe Ala Tyr Met Asn Tyr Arg Val Pro Arg Thr Arg 
1               5                   10                  15      


Lys Glu Ile Phe Glu Thr Leu Ile Lys Gly Leu Gln Arg Leu Glu Tyr 
            20                  25                  30          


Arg Gly Tyr Asp Ser Ala Gly Val Ala Ile Asp Gly Asn Asn His Glu 
        35                  40                  45              


Val Lys Glu Arg His Ile Gln Leu Val Lys Lys Arg Gly Lys Val Lys 
    50                  55                  60                  


Ala Leu Asp Glu Glu Leu Tyr Lys Gln Asp Ser Met Asp Leu Lys Val 
65                  70                  75                  80  


Glu Phe Glu Thr His Phe Gly Ile Ala His Thr Arg Trp Ala Thr His 
                85                  90                  95      


Gly Val Pro Ser Ala Val Asn Ser His Pro Gln Arg Ser Asp Lys Gly 
            100                 105                 110         


Asn Glu Phe Val Val Ile His Asn Gly Ile Ile Thr Asn Tyr Lys Asp 
        115                 120                 125             


Leu Arg Lys Phe Leu Glu Ser Lys Gly Tyr Glu Phe Glu Ser Glu Thr 
    130                 135                 140                 


Asp Thr Glu Thr Ile Ala Lys Leu Ile Lys Tyr Val Phe Asp Asn Arg 
145                 150                 155                 160 


Glu Thr Glu Asp Ile Thr Phe Ser Thr Leu Val Glu Arg Val Ile Gln 
                165                 170                 175     


Gln Leu Glu Gly Ala Phe Ala Leu Val Phe Lys Ser Val His Tyr Pro 
            180                 185                 190         


Gly Glu Ala Val Ala Thr Arg Arg Gly Ser Pro Leu Leu Ile Gly Val 
        195                 200                 205             


Arg Ser Lys Tyr Lys Leu Ser Thr Glu Gln Ile Pro Ile Leu Tyr Arg 
    210                 215                 220                 


Thr Cys Thr Leu Glu Asn Val Lys Asn Ile Cys Lys Thr Arg Met Lys 
225                 230                 235                 240 


Arg Leu Asp Ser Ser Ala Cys Leu His Ala Val Gly Asp Lys Ala Val 
                245                 250                 255     


Glu Phe Phe Phe Ala Ser Asp Ala Ser Ala Ile Ile Glu His Thr Asn 
            260                 265                 270         


Arg Val Ile Phe Leu Glu Asp Asp Asp Ile Ala Ala Val Ala Asp Gly 
        275                 280                 285             


Lys Leu Ser Ile His Arg Val Lys Arg Ser Ala Ser Asp Asp Pro Ser 
    290                 295                 300                 


Arg Ala Ile Gln Thr Leu Gln Met Glu Leu Gln Gln Ile Met Lys Gly 
305                 310                 315                 320 


Asn Phe Ser Ala Phe Met Gln Lys Glu Ile Phe Glu Gln Pro Glu Ser 
                325                 330                 335     


Val Phe Asn Thr Met Arg Gly Arg Val Asn Phe Glu Thr Asn Thr Val 
            340                 345                 350         


Leu Leu Gly Gly Leu Lys Asp His Leu Lys Glu Ile Arg Arg Cys Arg 
        355                 360                 365             


Arg Leu Ile Val Ile Gly Cys Gly Thr Ser Tyr His Ala Ala Val Ala 
    370                 375                 380                 


Thr Arg Gln Val Leu Glu Glu Leu Thr Glu Leu Pro Val Met Val Glu 
385                 390                 395                 400 


Leu Ala Ser Asp Phe Leu Asp Arg Asn Thr Pro Val Phe Arg Asp Asp 
                405                 410                 415     


Val Cys Phe Phe Ile Ser Gln Ser Gly Glu Thr Ala Asp Thr Leu Leu 
            420                 425                 430         


Ala Leu Arg Tyr Cys Lys Asp Arg Gly Ala Leu Thr Val Gly Val Thr 
        435                 440                 445             


Asn Thr Val Gly Ser Ser Ile Ser Arg Glu Thr Asp Cys Gly Val His 
    450                 455                 460                 


Ile Asn Ala Gly Pro Glu Ile Gly Val Ala Ser Thr Lys Ala Tyr Thr 
465                 470                 475                 480 


Ser Gln Phe Ile Ser Leu Val Met Phe Gly Leu Met Met Ser Glu Asp 
                485                 490                 495     


Arg Ile Ser Leu Gln Asn Arg Arg Gln Glu Ile Ile Arg Gly Leu Arg 
            500                 505                 510         


Ser Leu Pro Glu Leu Ile Lys Glu Val Leu Ser Leu Glu Glu Lys Ile 
        515                 520                 525             


His Asp Leu Ala Leu Glu Leu Tyr Thr Gln Arg Ser Leu Leu Val Met 
    530                 535                 540                 


Gly Arg Gly Tyr Asn Tyr Ala Thr Cys Leu Glu Gly Ala Leu Lys Ile 
545                 550                 555                 560 


Lys Glu Ile Thr Tyr Met His Ser Glu Gly Ile Leu Ala Gly Glu Leu 
                565                 570                 575     


Lys His Gly Pro Leu Ala Leu Ile Asp Lys Gln Met Pro Val Ile Met 
            580                 585                 590         


Val Ile Met Lys Asp Pro Cys Phe Ala Lys Cys Gln Asn Ala Leu Gln 
        595                 600                 605             


Gln Val Thr Ala Arg Gln Gly Arg Pro Ile Ile Leu Cys Ser Lys Asp 
    610                 615                 620                 


Asp Thr Glu Ser Ser Lys Phe Ala Tyr Lys Thr Ile Glu Leu Pro His 
625                 630                 635                 640 


Thr Val Asp Cys Leu Gln Gly Ile Leu Ser Val Ile Pro Leu Gln Leu 
                645                 650                 655     


Leu Ser Phe His Leu Ala Val Leu Arg Gly Tyr Asp Val Asp Phe Pro 
            660                 665                 670         


Arg Asn Leu Ala Lys Ser Val Thr Val Glu 
        675                 680         


<210>  5880
<211>  216
<212>  PRT
<213>  Homo Sapiens

<400>  5880

Met Asn Leu Leu Leu Asn Ser Ile Ser Leu Leu Thr Phe Leu Ser Glu 
1               5                   10                  15      


Phe Val Val Ile His Asn Gly Ile Ile Thr Asn Tyr Lys Asp Leu Arg 
            20                  25                  30          


Lys Phe Leu Glu Ser Lys Gly Tyr Glu Phe Glu Ser Glu Thr Asp Thr 
        35                  40                  45              


Glu Thr Ile Ala Lys Leu Ile Lys Tyr Val Phe Asp Asn Arg Glu Thr 
    50                  55                  60                  


Glu Asp Ile Thr Phe Ser Thr Leu Val Glu Arg Val Ile Gln Gln Leu 
65                  70                  75                  80  


Glu Gly Ala Phe Ala Leu Val Phe Lys Ser Val His Tyr Pro Gly Glu 
                85                  90                  95      


Ala Val Ala Thr Arg Arg Gly Ser Pro Leu Leu Ile Gly Val Arg Ser 
            100                 105                 110         


Lys Tyr Lys Leu Ser Thr Glu Gln Ile Pro Ile Leu Tyr Arg Thr Cys 
        115                 120                 125             


Thr Leu Glu Asn Val Lys Asn Ile Cys Lys Thr Arg Met Lys Arg Leu 
    130                 135                 140                 


Asp Ser Ser Ala Cys Leu His Ala Val Gly Asp Lys Ala Val Glu Phe 
145                 150                 155                 160 


Phe Phe Ala Ser Asp Ala Ser Ala Ile Ile Glu His Thr Asn Arg Val 
                165                 170                 175     


Ile Phe Leu Glu Asp Asp Asp Ile Ala Ala Val Ala Asp Gly Lys Leu 
            180                 185                 190         


Ser Ile His Arg Val Lys Arg Ser Ala Ser Asp Asp Pro Ser Arg Ala 
        195                 200                 205             


Ile Gln Thr Leu Gln Met Glu Leu 
    210                 215     


<210>  5881
<211>  179
<212>  PRT
<213>  Homo Sapiens

<400>  5881

Met Pro Thr Glu Val Ala Leu Leu His Val Ser Gln Ser Pro Thr Lys 
1               5                   10                  15      


Ala Ala Thr Arg Arg Pro Ala His Pro Glu Cys Gly Ala Pro Ile Pro 
            20                  25                  30          


Thr Gln Pro Ala Ala Pro Thr Glu Glu Arg Arg Gly Asp Pro Ala Pro 
        35                  40                  45              


Pro Ser Pro Gln Pro Ala Arg Ser Pro Pro Leu Arg Gln Cys Leu Arg 
    50                  55                  60                  


Gln Gly Leu Arg Val Leu Leu Ala Thr Pro Lys Glu Arg Leu Val Pro 
65                  70                  75                  80  


Arg Arg Val Ala Ala Ala Leu Pro Pro Leu Cys Ala Gly Lys Arg Gln 
                85                  90                  95      


Ser Leu Pro Glu Pro Arg Pro Glu Ala Thr Arg Gly Ser Pro Gly Arg 
            100                 105                 110         


Gly Ala Gly Pro Gly Val Arg Phe Pro Arg Arg Ser Arg Ala Val Pro 
        115                 120                 125             


Arg Gly Cys Gly Thr Val Gly Arg Ala Ala Ala Ala Arg Ser Ala His 
    130                 135                 140                 


Leu Gln Phe Phe Thr Leu Leu Ala Gly Pro Pro Pro Leu Ala Gly Arg 
145                 150                 155                 160 


Glu Pro Gly Thr Ser Ala Gly Thr Lys Gly Ile Phe Ala Tyr Met Asn 
                165                 170                 175     


Tyr Arg Val 
            


<210>  5882
<211>  464
<212>  PRT
<213>  Homo Sapiens

<400>  5882

Met Ile Leu Ala Asn Val Phe Cys Leu Phe Phe Phe Leu Asp Glu Thr 
1               5                   10                  15      


Leu Arg Ser Leu Ala Ser Pro Ser Ser Leu Gln Gly Pro Glu Leu His 
            20                  25                  30          


Gly Trp Arg Pro Pro Val Asp Cys Val Arg Ala Asn Glu Leu Cys Ala 
        35                  40                  45              


Ala Glu Ser Asn Cys Ser Ser Arg Tyr Arg Thr Leu Arg Gln Cys Leu 
    50                  55                  60                  


Ala Gly Arg Asp Arg Asn Thr Met Leu Ala Asn Lys Glu Cys Gln Ala 
65                  70                  75                  80  


Ala Leu Glu Val Leu Gln Glu Ser Pro Leu Tyr Asp Cys Arg Cys Lys 
                85                  90                  95      


Arg Gly Met Lys Lys Glu Leu Gln Cys Leu Gln Ile Tyr Trp Ser Ile 
            100                 105                 110         


His Leu Gly Leu Thr Glu Gly Glu Glu Phe Tyr Glu Ala Ser Pro Tyr 
        115                 120                 125             


Glu Pro Val Thr Ser Arg Leu Ser Asp Ile Phe Arg Leu Ala Ser Ile 
    130                 135                 140                 


Phe Ser Gly Thr Gly Ala Asp Pro Val Val Ser Ala Lys Ser Asn His 
145                 150                 155                 160 


Cys Leu Asp Ala Ala Lys Ala Cys Asn Leu Asn Asp Asn Cys Lys Lys 
                165                 170                 175     


Leu Arg Ser Ser Tyr Ile Ser Ile Cys Asn Arg Glu Ile Ser Pro Thr 
            180                 185                 190         


Glu Arg Cys Asn Arg Arg Lys Cys His Lys Ala Leu Arg Gln Phe Phe 
        195                 200                 205             


Asp Arg Val Pro Ser Glu Tyr Thr Tyr Arg Met Leu Phe Cys Ser Cys 
    210                 215                 220                 


Gln Asp Gln Ala Cys Ala Glu Arg Arg Arg Gln Thr Ile Leu Pro Ser 
225                 230                 235                 240 


Cys Ser Tyr Glu Asp Lys Glu Lys Pro Asn Cys Leu Asp Leu Arg Gly 
                245                 250                 255     


Val Cys Arg Thr Asp His Leu Cys Arg Ser Arg Leu Ala Asp Phe His 
            260                 265                 270         


Ala Asn Cys Arg Ala Ser Tyr Gln Thr Val Thr Ser Cys Pro Ala Asp 
        275                 280                 285             


Asn Tyr Gln Ala Cys Leu Gly Ser Tyr Ala Gly Met Ile Gly Phe Asp 
    290                 295                 300                 


Met Thr Pro Asn Tyr Val Asp Ser Ser Pro Thr Gly Ile Val Val Ser 
305                 310                 315                 320 


Pro Trp Cys Ser Cys Arg Gly Ser Gly Asn Met Glu Glu Glu Cys Glu 
                325                 330                 335     


Lys Phe Leu Arg Asp Phe Thr Glu Asn Pro Cys Leu Arg Asn Ala Ile 
            340                 345                 350         


Gln Ala Phe Gly Asn Gly Thr Asp Val Asn Val Ser Pro Lys Gly Pro 
        355                 360                 365             


Ser Phe Gln Ala Thr Gln Ala Pro Arg Val Glu Lys Thr Pro Ser Leu 
    370                 375                 380                 


Pro Asp Asp Leu Ser Asp Ser Thr Ser Leu Gly Thr Ser Val Ile Thr 
385                 390                 395                 400 


Thr Cys Thr Ser Val Gln Glu Gln Gly Leu Lys Ala Asn Asn Ser Lys 
                405                 410                 415     


Glu Leu Ser Met Cys Phe Thr Glu Leu Thr Thr Asn Ile Ile Pro Gly 
            420                 425                 430         


Ser Asn Lys Val Ile Lys Pro Asn Ser Gly Pro Ser Arg Ala Arg Pro 
        435                 440                 445             


Ser Ala Ala Leu Thr Val Leu Ser Val Leu Met Leu Lys Leu Ala Leu 
    450                 455                 460                 


<210>  5883
<211>  265
<212>  PRT
<213>  Homo Sapiens

<400>  5883

Met Ile Leu Ala Asn Val Phe Cys Leu Phe Phe Phe Leu Asp Glu Thr 
1               5                   10                  15      


Leu Arg Ser Leu Ala Ser Pro Ser Ser Leu Gln Gly Pro Glu Leu His 
            20                  25                  30          


Gly Trp Arg Pro Pro Val Asp Cys Val Arg Ala Asn Glu Leu Cys Ala 
        35                  40                  45              


Ala Glu Ser Asn Cys Ser Ser Arg Tyr Arg Thr Leu Arg Gln Cys Leu 
    50                  55                  60                  


Ala Gly Arg Asp Arg Asn Thr Met Leu Ala Asn Lys Glu Cys Gln Ala 
65                  70                  75                  80  


Ala Leu Glu Val Leu Gln Glu Ser Pro Leu Tyr Asp Cys Arg Cys Lys 
                85                  90                  95      


Arg Gly Met Lys Lys Glu Leu Gln Cys Leu Gln Ile Tyr Trp Ser Ile 
            100                 105                 110         


His Leu Gly Leu Thr Glu Gly Glu Glu Phe Tyr Glu Ala Ser Pro Tyr 
        115                 120                 125             


Glu Pro Val Thr Ser Arg Leu Ser Asp Ile Phe Arg Leu Ala Ser Ile 
    130                 135                 140                 


Phe Ser Gly Thr Gly Ala Asp Pro Val Val Ser Ala Lys Ser Asn His 
145                 150                 155                 160 


Cys Leu Asp Ala Ala Lys Ala Cys Asn Leu Asn Asp Asn Cys Lys Lys 
                165                 170                 175     


Leu Arg Ser Ser Tyr Ile Ser Ile Cys Asn Arg Glu Ile Ser Pro Thr 
            180                 185                 190         


Glu Arg Cys Asn Arg Arg Lys Cys His Lys Ala Leu Arg Gln Phe Phe 
        195                 200                 205             


Asp Arg Val Pro Ser Glu Tyr Thr Tyr Arg Met Leu Phe Cys Ser Cys 
    210                 215                 220                 


Gln Asp Gln Ala Cys Ala Glu Arg Arg Arg Gln Thr Ile Leu Pro Ser 
225                 230                 235                 240 


Cys Ser Tyr Glu Asp Lys Glu Lys Pro Asn Cys Leu Asp Leu Arg Gly 
                245                 250                 255     


Val Cys Arg Thr Asp His Leu Cys Arg 
            260                 265 


<210>  5884
<211>  464
<212>  PRT
<213>  Homo Sapiens

<400>  5884

Met Ile Leu Ala Asn Val Phe Cys Leu Phe Phe Phe Leu Asp Glu Thr 
1               5                   10                  15      


Leu Arg Ser Leu Ala Ser Pro Ser Ser Leu Gln Gly Pro Glu Leu His 
            20                  25                  30          


Gly Trp Arg Pro Pro Val Asp Cys Val Arg Ala Asn Glu Leu Cys Ala 
        35                  40                  45              


Ala Glu Ser Asn Cys Ser Ser Arg Tyr Arg Thr Leu Arg Gln Cys Leu 
    50                  55                  60                  


Ala Gly Arg Asp Arg Asn Thr Met Leu Ala Asn Lys Glu Cys Gln Ala 
65                  70                  75                  80  


Ala Leu Glu Val Leu Gln Glu Ser Pro Leu Tyr Asp Cys Arg Cys Lys 
                85                  90                  95      


Arg Gly Met Lys Lys Glu Leu Gln Cys Leu Gln Ile Tyr Trp Ser Ile 
            100                 105                 110         


His Leu Gly Leu Thr Glu Gly Glu Glu Phe Tyr Glu Ala Ser Pro Tyr 
        115                 120                 125             


Glu Pro Val Thr Ser Arg Leu Ser Asp Ile Phe Arg Leu Ala Ser Ile 
    130                 135                 140                 


Phe Ser Gly Thr Gly Ala Asp Pro Val Val Ser Ala Lys Ser Asn His 
145                 150                 155                 160 


Cys Leu Asp Ala Ala Lys Ala Cys Asn Leu Asn Asp Asn Cys Lys Lys 
                165                 170                 175     


Leu Arg Ser Ser Tyr Ile Ser Ile Cys Asn Arg Glu Ile Ser Pro Thr 
            180                 185                 190         


Glu Arg Cys Asn Arg Arg Lys Cys His Lys Ala Leu Arg Gln Phe Phe 
        195                 200                 205             


Asp Arg Val Pro Ser Glu Tyr Thr Tyr Arg Met Leu Phe Cys Ser Cys 
    210                 215                 220                 


Gln Asp Gln Ala Cys Ala Glu Arg Arg Arg Gln Thr Ile Leu Pro Ser 
225                 230                 235                 240 


Cys Ser Tyr Glu Asp Lys Glu Lys Pro Asn Cys Leu Asp Leu Arg Gly 
                245                 250                 255     


Val Cys Arg Thr Asp His Leu Cys Arg Ser Arg Leu Ala Asp Phe His 
            260                 265                 270         


Ala Asn Cys Arg Ala Ser Tyr Gln Thr Val Thr Ser Cys Pro Ala Asp 
        275                 280                 285             


Asn Tyr Gln Ala Cys Leu Gly Ser Tyr Ala Gly Met Ile Gly Phe Asp 
    290                 295                 300                 


Met Thr Pro Asn Tyr Val Asp Ser Ser Pro Thr Gly Ile Val Val Ser 
305                 310                 315                 320 


Pro Trp Cys Ser Cys Arg Gly Ser Gly Asn Met Glu Glu Glu Cys Glu 
                325                 330                 335     


Lys Phe Leu Arg Asp Phe Thr Glu Asn Pro Cys Leu Arg Asn Ala Ile 
            340                 345                 350         


Gln Ala Phe Gly Asn Gly Thr Asp Val Asn Val Ser Pro Lys Gly Pro 
        355                 360                 365             


Ser Phe Gln Ala Thr Gln Ala Pro Arg Val Glu Lys Thr Pro Ser Leu 
    370                 375                 380                 


Pro Asp Asp Leu Ser Asp Ser Thr Ser Leu Gly Thr Ser Val Ile Thr 
385                 390                 395                 400 


Thr Cys Thr Ser Val Gln Glu Gln Gly Leu Lys Ala Asn Asn Ser Lys 
                405                 410                 415     


Glu Leu Ser Met Cys Phe Thr Glu Leu Thr Thr Asn Ile Ile Pro Gly 
            420                 425                 430         


Ser Asn Lys Val Ile Lys Pro Asn Ser Gly Pro Ser Arg Ala Arg Pro 
        435                 440                 445             


Ser Ala Ala Leu Thr Val Leu Ser Val Leu Met Leu Lys Leu Ala Leu 
    450                 455                 460                 


<210>  5885
<211>  359
<212>  PRT
<213>  Homo Sapiens

<400>  5885

Met Ile Leu Ala Asn Val Phe Cys Leu Phe Phe Phe Leu Gly Glu Glu 
1               5                   10                  15      


Phe Tyr Glu Ala Ser Pro Tyr Glu Pro Val Thr Ser Arg Leu Ser Asp 
            20                  25                  30          


Ile Phe Arg Leu Ala Ser Ile Phe Ser Gly Thr Gly Ala Asp Pro Val 
        35                  40                  45              


Val Ser Ala Lys Ser Asn His Cys Leu Asp Ala Ala Lys Ala Cys Asn 
    50                  55                  60                  


Leu Asn Asp Asn Cys Lys Lys Leu Arg Ser Ser Tyr Ile Ser Ile Cys 
65                  70                  75                  80  


Asn Arg Glu Ile Ser Pro Thr Glu Arg Cys Asn Arg Arg Lys Cys His 
                85                  90                  95      


Lys Ala Leu Arg Gln Phe Phe Asp Arg Val Pro Ser Glu Tyr Thr Tyr 
            100                 105                 110         


Arg Met Leu Phe Cys Ser Cys Gln Asp Gln Ala Cys Ala Glu Arg Arg 
        115                 120                 125             


Arg Gln Thr Ile Leu Pro Ser Cys Ser Tyr Glu Asp Lys Glu Lys Pro 
    130                 135                 140                 


Asn Cys Leu Asp Leu Arg Gly Val Cys Arg Thr Asp His Leu Cys Arg 
145                 150                 155                 160 


Ser Arg Leu Ala Asp Phe His Ala Asn Cys Arg Ala Ser Tyr Gln Thr 
                165                 170                 175     


Val Thr Ser Cys Pro Ala Asp Asn Tyr Gln Ala Cys Leu Gly Ser Tyr 
            180                 185                 190         


Ala Gly Met Ile Gly Phe Asp Met Thr Pro Asn Tyr Val Asp Ser Ser 
        195                 200                 205             


Pro Thr Gly Ile Val Val Ser Pro Trp Cys Ser Cys Arg Gly Ser Gly 
    210                 215                 220                 


Asn Met Glu Glu Glu Cys Glu Lys Phe Leu Arg Asp Phe Thr Glu Asn 
225                 230                 235                 240 


Pro Cys Leu Arg Asn Ala Ile Gln Ala Phe Gly Asn Gly Thr Asp Val 
                245                 250                 255     


Asn Val Ser Pro Lys Gly Pro Ser Phe Gln Ala Thr Gln Ala Pro Arg 
            260                 265                 270         


Val Glu Lys Thr Pro Ser Leu Pro Asp Asp Leu Ser Asp Ser Thr Ser 
        275                 280                 285             


Leu Gly Thr Ser Val Ile Thr Thr Cys Thr Ser Val Gln Glu Gln Gly 
    290                 295                 300                 


Leu Lys Ala Asn Asn Ser Lys Glu Leu Ser Met Cys Phe Thr Glu Leu 
305                 310                 315                 320 


Thr Thr Asn Ile Ile Pro Gly Ser Asn Lys Val Ile Lys Pro Asn Ser 
                325                 330                 335     


Gly Pro Ser Arg Ala Arg Pro Ser Ala Ala Leu Thr Val Leu Ser Val 
            340                 345                 350         


Leu Met Leu Lys Leu Ala Leu 
        355                 


<210>  5886
<211>  62
<212>  PRT
<213>  Homo Sapiens

<400>  5886

Met Ile Leu Ala Asn Val Phe Cys Leu Phe Phe Phe Leu Gly Pro Gly 
1               5                   10                  15      


Pro Leu Leu Arg Arg Asn Gly Val Gln Arg Glu Lys Thr Cys Ser Tyr 
            20                  25                  30          


Ile Gln Gly Arg Met Met Pro Glu Phe Ser Leu Gly Tyr Glu Glu Gly 
        35                  40                  45              


Cys Pro Thr Glu Ser Pro Trp Cys Ala Leu Ala Lys Trp Val 
    50                  55                  60          


<210>  5887
<211>  331
<212>  PRT
<213>  Homo Sapiens

<400>  5887

Met Ile Leu Ala Asn Val Phe Cys Leu Phe Phe Phe Leu Gly Thr Gly 
1               5                   10                  15      


Ala Asp Pro Val Val Ser Ala Lys Ser Asn His Cys Leu Asp Ala Ala 
            20                  25                  30          


Lys Ala Cys Asn Leu Asn Asp Asn Cys Lys Lys Leu Arg Ser Ser Tyr 
        35                  40                  45              


Ile Ser Ile Cys Asn Arg Glu Ile Ser Pro Thr Glu Arg Cys Asn Arg 
    50                  55                  60                  


Arg Lys Cys His Lys Ala Leu Arg Gln Phe Phe Asp Arg Val Pro Ser 
65                  70                  75                  80  


Glu Tyr Thr Tyr Arg Met Leu Phe Cys Ser Cys Gln Asp Gln Ala Cys 
                85                  90                  95      


Ala Glu Arg Arg Arg Gln Thr Ile Leu Pro Ser Cys Ser Tyr Glu Asp 
            100                 105                 110         


Lys Glu Lys Pro Asn Cys Leu Asp Leu Arg Gly Val Cys Arg Thr Asp 
        115                 120                 125             


His Leu Cys Arg Ser Arg Leu Ala Asp Phe His Ala Asn Cys Arg Ala 
    130                 135                 140                 


Ser Tyr Gln Thr Val Thr Ser Cys Pro Ala Asp Asn Tyr Gln Ala Cys 
145                 150                 155                 160 


Leu Gly Ser Tyr Ala Gly Met Ile Gly Phe Asp Met Thr Pro Asn Tyr 
                165                 170                 175     


Val Asp Ser Ser Pro Thr Gly Ile Val Val Ser Pro Trp Cys Ser Cys 
            180                 185                 190         


Arg Gly Ser Gly Asn Met Glu Glu Glu Cys Glu Lys Phe Leu Arg Asp 
        195                 200                 205             


Phe Thr Glu Asn Pro Cys Leu Arg Asn Ala Ile Gln Ala Phe Gly Asn 
    210                 215                 220                 


Gly Thr Asp Val Asn Val Ser Pro Lys Gly Pro Ser Phe Gln Ala Thr 
225                 230                 235                 240 


Gln Ala Pro Arg Val Glu Lys Thr Pro Ser Leu Pro Asp Asp Leu Ser 
                245                 250                 255     


Asp Ser Thr Ser Leu Gly Thr Ser Val Ile Thr Thr Cys Thr Ser Val 
            260                 265                 270         


Gln Glu Gln Gly Leu Lys Ala Asn Asn Ser Lys Glu Leu Ser Met Cys 
        275                 280                 285             


Phe Thr Glu Leu Thr Thr Asn Ile Ile Pro Gly Ser Asn Lys Val Ile 
    290                 295                 300                 


Lys Pro Asn Ser Gly Pro Ser Arg Ala Arg Pro Ser Ala Ala Leu Thr 
305                 310                 315                 320 


Val Leu Ser Val Leu Met Leu Lys Leu Ala Leu 
                325                 330     


<210>  5888
<211>  74
<212>  PRT
<213>  Homo Sapiens

<400>  5888

Met Leu Ala Asn Lys Glu Cys Gln Ala Ala Leu Glu Val Leu Gln Glu 
1               5                   10                  15      


Ser Pro Leu Tyr Asp Cys Arg Cys Lys Arg Gly Met Lys Lys Glu Leu 
            20                  25                  30          


Gln Cys Leu Gln Ile Tyr Trp Ser Ile His Leu Gly Leu Thr Glu Gly 
        35                  40                  45              


Glu Glu Phe Tyr Glu Ala Ser Pro Tyr Glu Pro Val Thr Ser Arg Leu 
    50                  55                  60                  


Ser Asp Ile Phe Arg Leu Ala Ser Ile Phe 
65                  70                  


<210>  5889
<211>  299
<212>  PRT
<213>  Homo Sapiens

<400>  5889

Met Val Arg Cys Leu Gly Pro Ala Leu Leu Leu Leu Leu Leu Leu Gly 
1               5                   10                  15      


Ser Ala Ser Ser Val Gly Gly Asn Arg Cys Val Asp Ala Ala Glu Ala 
            20                  25                  30          


Cys Thr Ala Asp Ala Arg Cys Gln Arg Leu Arg Ser Glu Tyr Val Ala 
        35                  40                  45              


Gln Cys Leu Gly Arg Ala Ala Gln Gly Gly Cys Pro Arg Ala Arg Cys 
    50                  55                  60                  


Arg Arg Ala Leu Arg Arg Phe Phe Ala Arg Gly Pro Pro Ala Leu Thr 
65                  70                  75                  80  


His Ala Leu Leu Phe Cys Pro Cys Ala Gly Pro Ala Cys Ala Glu Arg 
                85                  90                  95      


Arg Arg Gln Thr Phe Val Pro Ser Cys Ala Phe Ser Gly Pro Gly Pro 
            100                 105                 110         


Ala Pro Pro Ser Cys Leu Glu Pro Leu Asn Phe Cys Glu Arg Ser Arg 
        115                 120                 125             


Val Cys Arg Cys Ala Arg Ala Ala Ala Gly Pro Trp Arg Gly Trp Gly 
    130                 135                 140                 


Arg Gly Leu Ser Pro Ala His Arg Pro Pro Ala Ala Gln Ala Ser Pro 
145                 150                 155                 160 


Pro Gly Leu Ser Gly Leu Val His Pro Ser Ala Gln Arg Pro Arg Arg 
                165                 170                 175     


Leu Pro Ala Gly Pro Gly Arg Pro Leu Pro Ala Arg Leu Arg Gly Pro 
            180                 185                 190         


Arg Gly Val Pro Ala Gly Thr Ala Val Thr Pro Asn Tyr Val Asp Asn 
        195                 200                 205             


Val Ser Ala Arg Val Ala Pro Trp Cys Asp Cys Gly Ala Ser Gly Asn 
    210                 215                 220                 


Arg Arg Glu Asp Cys Glu Ala Phe Arg Gly Leu Phe Thr Arg Asn Arg 
225                 230                 235                 240 


Cys Leu Asp Gly Ala Ile Gln Ala Phe Ala Ser Gly Trp Pro Pro Val 
                245                 250                 255     


Leu Leu Asp Gln Leu Asn Pro Gln Gly Asp Pro Glu His Ser Leu Leu 
            260                 265                 270         


Gln Val Ser Ser Thr Gly Arg Ala Leu Glu Arg Arg Ser Leu Leu Ser 
        275                 280                 285             


Ile Leu Pro Val Leu Ala Leu Pro Ala Leu Leu 
    290                 295                 


<210>  5890
<211>  182
<212>  PRT
<213>  Homo Sapiens

<400>  5890

Met Val Arg Cys Leu Gly Pro Ala Leu Leu Leu Leu Leu Leu Leu Gly 
1               5                   10                  15      


Ser Ala Ser Ser Val Gly Gly Asn Arg Cys Val Asp Ala Ala Glu Ala 
            20                  25                  30          


Cys Thr Ala Asp Ala Arg Cys Gln Arg Leu Arg Ser Glu Tyr Val Ala 
        35                  40                  45              


Gln Cys Leu Gly Arg Ala Ala Gln Gly Gly Cys Pro Arg Ala Arg Cys 
    50                  55                  60                  


Arg Arg Ala Leu Arg Arg Phe Phe Ala Arg Gly Pro Pro Ala Leu Thr 
65                  70                  75                  80  


His Ala Leu Leu Phe Cys Pro Cys Ala Gly Pro Ala Cys Ala Glu Arg 
                85                  90                  95      


Arg Arg Gln Thr Phe Val Pro Ser Cys Ala Phe Ser Gly Pro Gly Pro 
            100                 105                 110         


Ala Pro Pro Ser Cys Leu Glu Pro Leu Asn Phe Cys Glu Arg Ser Arg 
        115                 120                 125             


Val Cys Arg Pro Arg Leu Leu Ala Phe Gln Val Ser Cys Thr Pro Ala 
    130                 135                 140                 


Pro Ser Ala Pro Asp Gly Cys Leu Leu Asp Gln Gly Ala Arg Cys Leu 
145                 150                 155                 160 


Arg Ala Tyr Ala Gly Leu Val Gly Ser Pro Gln Ala Pro Pro Ser Pro 
                165                 170                 175     


Leu Thr Thr Trp Thr Thr 
            180         


<210>  5891
<211>  269
<212>  PRT
<213>  Homo Sapiens

<400>  5891

Met Val Arg Cys Leu Gly Pro Ala Leu Leu Leu Leu Leu Leu Leu Gly 
1               5                   10                  15      


Ser Ala Ser Ser Val Gly Gly Asn Arg Cys Val Asp Ala Ala Glu Ala 
            20                  25                  30          


Cys Thr Ala Asp Ala Arg Cys Gln Arg Leu Arg Ser Glu Tyr Val Ala 
        35                  40                  45              


Gln Cys Leu Gly Arg Ala Ala Gln Gly Gly Cys Pro Arg Ala Arg Cys 
    50                  55                  60                  


Arg Arg Ala Leu Arg Arg Phe Phe Ala Arg Gly Pro Pro Ala Leu Thr 
65                  70                  75                  80  


His Ala Leu Leu Phe Cys Pro Cys Ala Gly Pro Ala Cys Ala Glu Arg 
                85                  90                  95      


Arg Arg Gln Thr Phe Val Pro Ser Cys Ala Phe Ser Gly Pro Gly Pro 
            100                 105                 110         


Ala Pro Pro Ser Cys Leu Glu Pro Leu Asn Phe Cys Glu Arg Ser Arg 
        115                 120                 125             


Val Cys Arg Pro Arg Leu Leu Ala Phe Gln Val Ser Cys Thr Pro Ala 
    130                 135                 140                 


Pro Ser Ala Pro Asp Gly Cys Leu Leu Asp Gln Gly Ala Arg Cys Leu 
145                 150                 155                 160 


Arg Ala Tyr Ala Gly Leu Val Gly Thr Ala Val Thr Pro Asn Tyr Val 
                165                 170                 175     


Asp Asn Val Ser Ala Arg Val Ala Pro Trp Cys Asp Cys Gly Ala Ser 
            180                 185                 190         


Gly Asn Arg Arg Glu Asp Cys Glu Ala Phe Arg Gly Leu Phe Thr Arg 
        195                 200                 205             


Asn Arg Cys Leu Asp Gly Ala Ile Gln Ala Phe Ala Ser Gly Trp Pro 
    210                 215                 220                 


Pro Val Leu Leu Asp Gln Leu Asn Pro Gln Gly Asp Pro Glu His Ser 
225                 230                 235                 240 


Leu Leu Gln Val Ser Ser Thr Gly Arg Ala Leu Glu Arg Arg Ser Leu 
                245                 250                 255     


Leu Ser Ile Leu Pro Val Leu Ala Leu Pro Ala Leu Leu 
            260                 265                 


<210>  5892
<211>  59
<212>  PRT
<213>  Homo Sapiens

<400>  5892

Met Ala Ala Thr Ala Val Ala Ala Ala Val Ala Gly Thr Glu Ser Ala 
1               5                   10                  15      


Gln Gly Pro Pro Gly Pro Ala Ala Ser Leu Glu Leu Trp Leu Asn Lys 
            20                  25                  30          


Ala Thr Asp Pro Ser Met Ser Glu Gln Asp Trp Ser Ala Ile Gln Asn 
        35                  40                  45              


Phe Cys Glu Gln Val Asn Thr Asp Pro Asn Gly 
    50                  55                  


<210>  5893
<211>  59
<212>  PRT
<213>  Homo Sapiens

<400>  5893

Met Ala Ala Thr Ala Val Ala Ala Ala Val Ala Gly Thr Glu Ser Ala 
1               5                   10                  15      


Gln Gly Pro Pro Gly Pro Ala Ala Ser Leu Glu Leu Trp Leu Asn Lys 
            20                  25                  30          


Ala Thr Asp Pro Ser Met Ser Glu Gln Asp Trp Ser Ala Ile Gln Asn 
        35                  40                  45              


Phe Cys Glu Gln Val Asn Thr Asp Pro Asn Gly 
    50                  55                  


<210>  5894
<211>  59
<212>  PRT
<213>  Homo Sapiens

<400>  5894

Met Ala Ala Thr Ala Val Ala Ala Ala Val Ala Gly Thr Glu Ser Ala 
1               5                   10                  15      


Gln Gly Pro Pro Gly Pro Ala Ala Ser Leu Glu Leu Trp Leu Asn Lys 
            20                  25                  30          


Ala Thr Asp Pro Ser Met Ser Glu Gln Asp Trp Ser Ala Ile Gln Asn 
        35                  40                  45              


Phe Cys Glu Gln Val Asn Thr Asp Pro Asn Gly 
    50                  55                  


<210>  5895
<211>  117
<212>  PRT
<213>  Homo Sapiens

<400>  5895

Met Ala Ala Thr Ala Val Ala Ala Ala Val Ala Gly Thr Glu Ser Ala 
1               5                   10                  15      


Gln Gly Pro Pro Gly Pro Ala Ala Ser Leu Glu Leu Trp Leu Asn Lys 
            20                  25                  30          


Ala Thr Asp Pro Ser Met Ser Glu Gln Asp Trp Ser Ala Ile Gln Asn 
        35                  40                  45              


Phe Cys Glu Gln Val Asn Thr Asp Pro Asn Gly Pro Thr His Ala Pro 
    50                  55                  60                  


Trp Leu Leu Ala His Lys Ile Gln Ser Pro Gln Glu Lys Glu Ala Leu 
65                  70                  75                  80  


Tyr Ala Leu Thr Pro Gly Gly Glu Pro Gly Thr Thr Gly Phe Pro Pro 
                85                  90                  95      


Ser Pro Gly Gly Pro Val Ser Val Gln Val Leu Glu Met Cys Met Asn 
            100                 105                 110         


His Cys Gly Glu Lys 
        115         


<210>  5896
<211>  613
<212>  PRT
<213>  Homo Sapiens

<400>  5896

Met Ala Ala Thr Ala Val Ala Ala Ala Val Ala Gly Thr Glu Ser Ala 
1               5                   10                  15      


Gln Gly Pro Pro Gly Pro Ala Ala Ser Leu Glu Leu Trp Leu Asn Lys 
            20                  25                  30          


Ala Thr Asp Pro Ser Met Ser Glu Gln Asp Trp Ser Ala Ile Gln Asn 
        35                  40                  45              


Phe Cys Glu Gln Val Asn Thr Asp Pro Asn Gly Pro Thr His Ala Pro 
    50                  55                  60                  


Trp Leu Leu Ala His Lys Ile Gln Ser Pro Gln Glu Lys Glu Ala Leu 
65                  70                  75                  80  


Tyr Ala Leu Thr Val Leu Glu Met Cys Met Asn His Cys Gly Glu Lys 
                85                  90                  95      


Phe His Ser Glu Val Ala Lys Phe Arg Phe Leu Asn Glu Leu Ile Lys 
            100                 105                 110         


Val Leu Ser Pro Lys Tyr Leu Gly Ser Trp Ala Thr Gly Lys Val Lys 
        115                 120                 125             


Gly Arg Val Ile Glu Ile Leu Phe Ser Trp Thr Val Trp Phe Pro Glu 
    130                 135                 140                 


Asp Ile Lys Ile Arg Asp Ala Tyr Gln Met Leu Lys Lys Gln Gly Ile 
145                 150                 155                 160 


Ile Lys Gln Asp Pro Lys Leu Pro Val Asp Lys Ile Leu Pro Pro Pro 
                165                 170                 175     


Ser Pro Trp Pro Lys Ser Ser Ile Phe Asp Ala Asp Glu Glu Lys Ser 
            180                 185                 190         


Lys Leu Leu Thr Arg Leu Leu Lys Ser Asn His Pro Glu Asp Leu Gln 
        195                 200                 205             


Ala Ala Asn Arg Leu Ile Lys Asn Leu Val Lys Glu Glu Gln Glu Lys 
    210                 215                 220                 


Ser Glu Lys Val Ser Lys Arg Val Ser Ala Val Glu Glu Val Arg Ser 
225                 230                 235                 240 


His Val Lys Val Leu Gln Glu Met Leu Ser Met Tyr Arg Arg Pro Gly 
                245                 250                 255     


Gln Ala Pro Pro Asp Gln Glu Ala Leu Gln Val Val Tyr Glu Arg Cys 
            260                 265                 270         


Glu Lys Leu Arg Pro Thr Leu Phe Arg Leu Ala Ser Asp Thr Thr Asp 
        275                 280                 285             


Asp Asp Asp Ala Leu Ala Glu Ile Leu Gln Ala Asn Asp Leu Leu Thr 
    290                 295                 300                 


Gln Gly Val Leu Leu Tyr Lys Gln Val Met Glu Gly Arg Val Thr Phe 
305                 310                 315                 320 


Gly Asn Arg Val Thr Ser Ser Leu Gly Asp Ile Pro Val Ser Arg Val 
                325                 330                 335     


Phe Gln Asn Pro Ala Gly Cys Met Lys Thr Cys Pro Leu Ile Asp Leu 
            340                 345                 350         


Glu Val Asp Asn Gly Pro Ala Gln Met Gly Thr Val Val Pro Ser Leu 
        355                 360                 365             


Leu His Gln Asp Leu Ala Ala Leu Gly Ile Ser Asp Ala Pro Val Thr 
    370                 375                 380                 


Gly Met Val Ser Gly Gln Asn Cys Cys Glu Glu Lys Arg Asn Pro Ser 
385                 390                 395                 400 


Ser Ser Thr Leu Pro Gly Gly Gly Val Gln Asn Pro Ser Ala Asp Arg 
                405                 410                 415     


Asn Leu Leu Asp Leu Leu Ser Ala Gln Pro Ala Pro Cys Pro Leu Asn 
            420                 425                 430         


Tyr Val Ser Gln Lys Ser Val Pro Lys Glu Val Pro Pro Gly Thr Lys 
        435                 440                 445             


Ser Ser Pro Gly Trp Ser Trp Glu Ala Gly Pro Leu Ala Pro Ser Pro 
    450                 455                 460                 


Ser Ser Gln Asn Thr Pro Leu Ala Gln Val Phe Val Pro Leu Glu Ser 
465                 470                 475                 480 


Val Lys Pro Ser Ser Leu Pro Pro Leu Ile Val Tyr Asp Arg Asn Gly 
                485                 490                 495     


Phe Arg Ile Leu Leu His Phe Ser Gln Thr Gly Ala Pro Gly His Pro 
            500                 505                 510         


Glu Val Gln Val Leu Leu Leu Thr Met Met Ser Thr Ala Pro Gln Pro 
        515                 520                 525             


Val Trp Asp Ile Met Phe Gln Val Ala Val Pro Lys Ser Met Arg Val 
    530                 535                 540                 


Lys Leu Gln Pro Ala Ser Ser Ser Lys Leu Pro Ala Phe Ser Pro Leu 
545                 550                 555                 560 


Met Pro Pro Ala Val Ile Ser Gln Met Leu Leu Leu Asp Asn Pro His 
                565                 570                 575     


Lys Glu Pro Ile Arg Leu Arg Tyr Lys Leu Thr Phe Asn Gln Gly Gly 
            580                 585                 590         


Gln Pro Phe Ser Glu Val Gly Glu Val Lys Asp Phe Pro Asp Leu Ala 
        595                 600                 605             


Val Leu Gly Ala Ala 
    610             


<210>  5897
<211>  223
<212>  PRT
<213>  Homo Sapiens

<400>  5897

Met Ala Ala Thr Ala Val Ala Ala Ala Val Ala Gly Thr Glu Ser Ala 
1               5                   10                  15      


Gln Gly Pro Pro Gly Pro Ala Ala Ser Leu Glu Leu Trp Leu Asn Lys 
            20                  25                  30          


Ala Thr Asp Pro Ser Met Ser Glu Gln Asp Trp Ser Ala Ile Gln Asn 
        35                  40                  45              


Phe Cys Glu Gln Val Asn Thr Asp Pro Asn Gly Pro Thr His Ala Pro 
    50                  55                  60                  


Trp Leu Leu Ala His Lys Ile Gln Ser Pro Gln Glu Lys Glu Ala Leu 
65                  70                  75                  80  


Tyr Ala Leu Thr Val Leu Glu Met Cys Met Asn His Cys Gly Glu Lys 
                85                  90                  95      


Phe His Ser Glu Val Ala Lys Phe Arg Phe Leu Asn Glu Leu Ile Lys 
            100                 105                 110         


Val Leu Ser Pro Lys Tyr Leu Gly Ser Trp Ala Thr Gly Lys Val Lys 
        115                 120                 125             


Gly Arg Val Ile Glu Ile Leu Phe Ser Trp Thr Val Trp Phe Pro Glu 
    130                 135                 140                 


Asp Ile Lys Ile Arg Asp Ala Tyr Gln Met Leu Lys Lys Gln Gly Ile 
145                 150                 155                 160 


Ile Lys Gln Asp Pro Lys Leu Pro Val Asp Lys Ile Leu Pro Pro Pro 
                165                 170                 175     


Ser Pro Trp Pro Lys Ser Ser Ile Phe Asp Ala Asp Glu Glu Lys Ser 
            180                 185                 190         


Lys Leu Leu Thr Arg Leu Leu Lys Ser Asn His Pro Glu Asp Leu Gln 
        195                 200                 205             


Ala Ala Val Leu Lys Val Ala Val Val Tyr Gly Ile Thr Pro Phe 
    210                 215                 220             


<210>  5898
<211>  49
<212>  PRT
<213>  Homo Sapiens

<400>  5898

Met Ala Ala Thr Ala Val Ala Ala Ala Val Ala Gly Thr Glu Ser Ala 
1               5                   10                  15      


Gln Gly Pro Pro Gly Pro Ala Ala Ser Leu Glu Leu Trp Leu Ser Asp 
            20                  25                  30          


His Arg Pro Lys His Val Gly Thr Gly Leu Val Ser Tyr Pro Glu Phe 
        35                  40                  45              


Leu 
    


<210>  5899
<211>  125
<212>  PRT
<213>  Homo Sapiens

<400>  5899

Met Val Lys Leu Pro Phe Ser Leu Ser Leu Gln Leu Ala Asn Ser Cys 
1               5                   10                  15      


Pro Ser Pro Glu Asp Lys Ala Thr Asp Pro Ser Met Ser Glu Gln Asp 
            20                  25                  30          


Trp Ser Ala Ile Gln Asn Phe Cys Glu Gln Val Asn Thr Asp Pro Asn 
        35                  40                  45              


Gly Pro Thr His Ala Pro Trp Leu Leu Ala His Lys Ile Gln Ser Pro 
    50                  55                  60                  


Gln Glu Lys Glu Ala Leu Tyr Ala Leu Thr Val Leu Glu Met Cys Met 
65                  70                  75                  80  


Asn His Cys Gly Glu Lys Phe His Ser Glu Val Ala Lys Phe Arg Phe 
                85                  90                  95      


Leu Asn Glu Leu Ile Lys Val Leu Ser Pro Lys Tyr Leu Gly Ser Trp 
            100                 105                 110         


Ala Thr Gly Lys Val Lys Gly Arg Val Ile Glu Ile Leu 
        115                 120                 125 


<210>  5900
<211>  129
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5900

Xaa Ala Val Ala Gly Thr Glu Ser Ala Gln Gly Pro Pro Gly Pro Ala 
1               5                   10                  15      


Ala Ser Leu Glu Leu Trp Leu Asn Lys Ala Thr Asp Pro Ser Met Ser 
            20                  25                  30          


Glu Gln Asp Trp Ser Ala Ile Gln Asn Phe Cys Glu Gln Val Asn Thr 
        35                  40                  45              


Asp Pro Asn Gly Pro Thr His Ala Pro Trp Leu Leu Ala His Lys Ile 
    50                  55                  60                  


Gln Ser Pro Gln Glu Lys Glu Ala Leu Tyr Ala Leu Thr Cys Pro His 
65                  70                  75                  80  


Arg Leu Glu Ala Gly Leu Ala Leu Val Pro Ala Gln Ser Pro Ala Ser 
                85                  90                  95      


Asp Tyr Gln Pro Gly Gly Glu Pro Gly Thr Thr Gly Phe Pro Pro Ser 
            100                 105                 110         


Pro Gly Gly Pro Val Ser Val Gln Val Leu Glu Met Cys Met Asn His 
        115                 120                 125             


Cys 
    


<210>  5901
<211>  318
<212>  PRT
<213>  Homo Sapiens

<400>  5901

Met Ala Ser Pro Gly Cys Leu Leu Cys Val Leu Gly Leu Leu Leu Cys 
1               5                   10                  15      


Gly Ala Ala Ser Leu Glu Leu Ser Arg Pro His Gly Asp Thr Ala Lys 
            20                  25                  30          


Lys Pro Ile Ile Gly Ile Leu Met Gln Lys Cys Arg Asn Lys Val Met 
        35                  40                  45              


Lys Asn Tyr Gly Arg Tyr Tyr Ile Ala Ala Ser Tyr Val Lys Tyr Leu 
    50                  55                  60                  


Glu Ser Ala Gly Ala Arg Val Val Pro Val Arg Leu Asp Leu Thr Glu 
65                  70                  75                  80  


Lys Asp Tyr Glu Ile Leu Phe Lys Ser Ile Asn Gly Ile Leu Phe Pro 
                85                  90                  95      


Gly Gly Ser Val Asp Leu Arg Arg Ser Asp Tyr Ala Lys Val Ala Lys 
            100                 105                 110         


Ile Phe Tyr Asn Leu Ser Ile Gln Ser Phe Asp Asp Gly Asp Tyr Phe 
        115                 120                 125             


Pro Val Trp Gly Thr Cys Leu Gly Phe Glu Glu Leu Ser Leu Leu Ile 
    130                 135                 140                 


Ser Gly Glu Cys Leu Leu Thr Ala Thr Asp Thr Val Asp Val Ala Met 
145                 150                 155                 160 


Pro Leu Asn Phe Thr Gly Gly Gln Leu His Ser Arg Met Phe Gln Asn 
                165                 170                 175     


Phe Pro Thr Glu Leu Leu Leu Ser Leu Ala Val Glu Pro Leu Thr Ala 
            180                 185                 190         


Asn Phe His Lys Trp Ser Leu Ser Val Lys Asn Phe Thr Met Asn Glu 
        195                 200                 205             


Lys Leu Lys Lys Phe Phe Asn Val Leu Thr Thr Asn Thr Asp Gly Lys 
    210                 215                 220                 


Ile Glu Phe Ile Ser Thr Met Glu Gly Tyr Lys Tyr Pro Val Tyr Gly 
225                 230                 235                 240 


Val Gln Trp His Pro Glu Lys Ala Pro Tyr Glu Trp Lys Asn Leu Asp 
                245                 250                 255     


Gly Ile Ser His Ala Pro Asn Ala Val Lys Thr Ala Phe Tyr Leu Ala 
            260                 265                 270         


Glu Phe Phe Val Asn Glu Ala Arg Lys Asn Asn His His Phe Lys Ser 
        275                 280                 285             


Glu Ser Glu Glu Glu Lys Ala Leu Ile Tyr Gln Phe Ser Pro Ile Tyr 
    290                 295                 300                 


Thr Gly Asn Ile Ser Ser Phe Gln Gln Cys Tyr Ile Phe Asp 
305                 310                 315             


<210>  5902
<211>  30
<212>  PRT
<213>  Homo Sapiens

<400>  5902

Met Lys Lys Lys Leu Val Val Leu Gly Leu Leu Ala Val Val Leu Val 
1               5                   10                  15      


Leu Val Ile Val Gly Leu Cys Leu Trp Leu Pro Ser Ala Ser 
            20                  25                  30  


<210>  5903
<211>  37
<212>  PRT
<213>  Homo Sapiens

<400>  5903

Met Lys Lys Lys Leu Val Val Leu Gly Leu Leu Ala Val Val Leu Val 
1               5                   10                  15      


Leu Val Ile Val Gly Leu Cys Leu Trp Leu Pro Ser Ala Ser Lys Glu 
            20                  25                  30          


Pro Asp Asn His Val 
        35          


<210>  5904
<211>  68
<212>  PRT
<213>  Homo Sapiens

<400>  5904

Met Lys Lys Lys Leu Val Val Leu Gly Leu Leu Ala Val Val Leu Val 
1               5                   10                  15      


Leu Val Ile Val Gly Leu Cys Leu Trp Leu Pro Ser Ala Ser Lys Glu 
            20                  25                  30          


Pro Asp Asn His Val Tyr Thr Arg Ala Ala Val Ala Ala Asp Ala Lys 
        35                  40                  45              


Gln Cys Ser Lys Ile Gly Arg Asp Ala Leu Arg Asp Gly Gly Ser Ala 
    50                  55                  60                  


Val Asp Ala Ala 
65              


<210>  5905
<211>  80
<212>  PRT
<213>  Homo Sapiens

<400>  5905

Met Lys Lys Lys Leu Val Val Leu Gly Leu Leu Ala Val Val Leu Val 
1               5                   10                  15      


Leu Val Ile Val Gly Leu Cys Leu Trp Leu Pro Ser Ala Ser Lys Glu 
            20                  25                  30          


Pro Asp Asn His Val Tyr Thr Arg Ala Ala Val Ala Ala Asp Ala Lys 
        35                  40                  45              


Gln Cys Ser Lys Ile Gly Arg Asp Ala Leu Arg Asp Gly Gly Ser Ala 
    50                  55                  60                  


Val Asp Ala Ala Ile Ala Ala Leu Leu Cys Val Gly Leu Met Asn Ala 
65                  70                  75                  80  


<210>  5906
<211>  98
<212>  PRT
<213>  Homo Sapiens

<400>  5906

Met Lys Lys Lys Leu Val Val Leu Gly Leu Leu Ala Val Val Leu Val 
1               5                   10                  15      


Leu Val Ile Val Gly Leu Cys Leu Trp Leu Pro Ser Ala Ser Lys Glu 
            20                  25                  30          


Pro Asp Asn His Val Tyr Thr Arg Ala Ala Val Ala Ala Asp Ala Lys 
        35                  40                  45              


Gln Cys Ser Lys Ile Gly Arg Asp Ala Leu Arg Asp Gly Gly Ser Ala 
    50                  55                  60                  


Val Asp Ala Ala Ile Ala Ala Leu Leu Cys Val Gly Leu Met Asn Ala 
65                  70                  75                  80  


His Ser Met Gly Ile Gly Gly Gly Leu Phe Leu Thr Ile Tyr Asn Ser 
                85                  90                  95      


Thr Thr 
        


<210>  5907
<211>  109
<212>  PRT
<213>  Homo Sapiens

<400>  5907

Met Lys Lys Lys Leu Val Val Leu Gly Leu Leu Ala Val Val Leu Val 
1               5                   10                  15      


Leu Val Ile Val Gly Leu Cys Leu Trp Leu Pro Ser Ala Ser Lys Glu 
            20                  25                  30          


Pro Asp Asn His Val Tyr Thr Arg Ala Ala Val Ala Ala Asp Ala Lys 
        35                  40                  45              


Gln Cys Ser Lys Ile Gly Arg Asp Ala Leu Arg Asp Gly Gly Ser Ala 
    50                  55                  60                  


Val Asp Ala Ala Ile Ala Ala Leu Leu Cys Val Gly Leu Met Asn Ala 
65                  70                  75                  80  


His Ser Met Gly Ile Gly Gly Gly Leu Phe Leu Thr Ile Tyr Asn Ser 
                85                  90                  95      


Thr Thr Arg Lys Ala Glu Val Ile Asn Ala Arg Glu Val 
            100                 105                 


<210>  5908
<211>  111
<212>  PRT
<213>  Homo Sapiens

<400>  5908

Met Lys Lys Lys Leu Val Val Leu Gly Leu Leu Ala Val Val Leu Val 
1               5                   10                  15      


Leu Val Ile Val Gly Leu Cys Leu Trp Leu Pro Ser Ala Ser Lys Glu 
            20                  25                  30          


Pro Asp Asn His Val Tyr Thr Arg Ala Ala Val Ala Ala Asp Ala Lys 
        35                  40                  45              


Gln Cys Ser Lys Ile Gly Arg Asp Ala Leu Arg Asp Gly Gly Ser Ala 
    50                  55                  60                  


Val Asp Ala Ala Ile Ala Ala Leu Leu Cys Val Gly Leu Met Asn Ala 
65                  70                  75                  80  


His Ser Met Gly Ile Gly Gly Gly Leu Phe Leu Thr Ile Tyr Asn Ser 
                85                  90                  95      


Thr Thr Arg Lys Ala Glu Val Ile Asn Ala Arg Glu Val Ala Pro 
            100                 105                 110     


<210>  5909
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  5909

Met Lys Lys Lys Leu Val Val Leu Gly Leu Leu Ala Val Val Leu Val 
1               5                   10                  15      


Leu Val Ile Val Gly Leu Cys Leu Trp Leu Pro Ser Ala Ser Lys Glu 
            20                  25                  30          


Pro Asp Asn His Val Tyr Thr Arg Ala Ala Val Ala Ala Asp Ala Lys 
        35                  40                  45              


Gln Cys Ser Lys Ile Gly Arg Asp Ala Leu Arg Asp Gly Gly Ser Ala 
    50                  55                  60                  


Val Asp Ala Ala Ile Ala Ala Leu Leu Cys Val Gly Leu Met Asn Ala 
65                  70                  75                  80  


His Ser Met Gly Ile Gly Gly Gly Leu Phe Leu Thr Ile Tyr Asn Ser 
                85                  90                  95      


Thr Thr Arg Lys Ala Glu Val Ile Asn Ala Arg Glu Val Ala Pro Arg 
            100                 105                 110         


Leu Ala Phe Ala 
        115     


<210>  5910
<211>  120
<212>  PRT
<213>  Homo Sapiens

<400>  5910

Met Lys Lys Lys Leu Val Val Leu Gly Leu Leu Ala Val Val Leu Val 
1               5                   10                  15      


Leu Val Ile Val Gly Leu Cys Leu Trp Leu Pro Ser Ala Ser Lys Glu 
            20                  25                  30          


Pro Asp Asn His Val Tyr Thr Arg Ala Ala Val Ala Ala Asp Ala Lys 
        35                  40                  45              


Gln Cys Ser Lys Ile Gly Arg Asp Ala Leu Arg Asp Gly Gly Ser Ala 
    50                  55                  60                  


Val Asp Ala Ala Ile Ala Ala Leu Leu Cys Val Gly Leu Met Asn Ala 
65                  70                  75                  80  


His Ser Met Gly Ile Gly Gly Gly Leu Phe Leu Thr Ile Tyr Asn Ser 
                85                  90                  95      


Thr Thr Arg Lys Ala Glu Val Ile Asn Ala Arg Glu Val Ala Pro Arg 
            100                 105                 110         


Leu Ala Phe Ala Thr Met Phe Asn 
        115                 120 


<210>  5911
<211>  126
<212>  PRT
<213>  Homo Sapiens

<400>  5911

Met Lys Lys Lys Leu Val Val Leu Gly Leu Leu Ala Val Val Leu Val 
1               5                   10                  15      


Leu Val Ile Val Gly Leu Cys Leu Trp Leu Pro Ser Ala Ser Lys Glu 
            20                  25                  30          


Pro Asp Asn His Val Tyr Thr Arg Ala Ala Val Ala Ala Asp Ala Lys 
        35                  40                  45              


Gln Cys Ser Lys Ile Gly Arg Asp Ala Leu Arg Asp Gly Gly Ser Ala 
    50                  55                  60                  


Val Asp Ala Ala Ile Ala Ala Leu Leu Cys Val Gly Leu Met Asn Ala 
65                  70                  75                  80  


His Ser Met Gly Ile Gly Gly Gly Leu Phe Leu Thr Ile Tyr Asn Ser 
                85                  90                  95      


Thr Thr Arg Lys Ala Glu Val Ile Asn Ala Arg Glu Val Ala Pro Arg 
            100                 105                 110         


Leu Ala Phe Ala Thr Met Phe Asn Ser Ser Glu Gln Ser Gln 
        115                 120                 125     


<210>  5912
<211>  126
<212>  PRT
<213>  Homo Sapiens

<400>  5912

Met Lys Lys Lys Leu Val Val Leu Gly Leu Leu Ala Val Val Leu Val 
1               5                   10                  15      


Leu Val Ile Val Gly Leu Cys Leu Trp Leu Pro Ser Ala Ser Lys Glu 
            20                  25                  30          


Pro Asp Asn His Val Tyr Thr Arg Ala Ala Val Ala Ala Asp Ala Lys 
        35                  40                  45              


Gln Cys Ser Lys Ile Gly Arg Asp Ala Leu Arg Asp Gly Gly Ser Ala 
    50                  55                  60                  


Val Asp Ala Ala Ile Ala Ala Leu Leu Cys Val Gly Leu Met Asn Ala 
65                  70                  75                  80  


His Ser Met Gly Ile Gly Gly Gly Leu Phe Leu Thr Ile Tyr Asn Ser 
                85                  90                  95      


Thr Thr Arg Lys Ala Glu Val Ile Asn Ala Arg Glu Val Ala Pro Arg 
            100                 105                 110         


Leu Ala Phe Ala Thr Met Phe Asn Ser Ser Glu Gln Ser Gln 
        115                 120                 125     


<210>  5913
<211>  127
<212>  PRT
<213>  Homo Sapiens

<400>  5913

Met Lys Lys Lys Leu Val Val Leu Gly Leu Leu Ala Val Val Leu Val 
1               5                   10                  15      


Leu Val Ile Val Gly Leu Cys Leu Trp Leu Pro Ser Ala Ser Lys Glu 
            20                  25                  30          


Pro Asp Asn His Val Tyr Thr Arg Ala Ala Val Ala Ala Asp Ala Lys 
        35                  40                  45              


Gln Cys Ser Lys Ile Gly Arg Asp Ala Leu Arg Asp Gly Gly Ser Ala 
    50                  55                  60                  


Val Asp Ala Ala Ile Ala Ala Leu Leu Cys Val Gly Leu Met Asn Ala 
65                  70                  75                  80  


His Ser Met Gly Ile Gly Gly Gly Leu Phe Leu Thr Ile Tyr Asn Ser 
                85                  90                  95      


Thr Thr Arg Lys Ala Glu Val Ile Asn Ala Arg Glu Val Ala Pro Arg 
            100                 105                 110         


Leu Ala Phe Ala Thr Met Phe Asn Ser Ser Glu Gln Ser Gln Lys 
        115                 120                 125         


<210>  5914
<211>  174
<212>  PRT
<213>  Homo Sapiens

<400>  5914

Met Lys Lys Lys Leu Val Val Leu Gly Leu Leu Ala Val Val Leu Val 
1               5                   10                  15      


Leu Val Ile Val Gly Leu Cys Leu Trp Leu Pro Ser Ala Ser Lys Glu 
            20                  25                  30          


Pro Asp Asn His Val Tyr Thr Arg Ala Ala Val Ala Ala Asp Ala Lys 
        35                  40                  45              


Gln Cys Ser Lys Ile Gly Arg Asp Ala Leu Arg Asp Gly Gly Ser Ala 
    50                  55                  60                  


Val Asp Ala Ala Ile Ala Ala Leu Leu Cys Val Gly Leu Met Asn Ala 
65                  70                  75                  80  


His Ser Met Gly Ile Gly Gly Gly Leu Phe Leu Thr Ile Tyr Asn Ser 
                85                  90                  95      


Thr Thr Arg Lys Ala Glu Val Ile Asn Ala Arg Glu Val Ala Pro Arg 
            100                 105                 110         


Leu Ala Phe Ala Thr Met Phe Asn Ser Ser Glu Gln Ser Gln Lys Gly 
        115                 120                 125             


Gly Leu Ser Val Ala Val Pro Gly Glu Ile Arg Gly Tyr Glu Leu Ala 
    130                 135                 140                 


His Gln Arg His Gly Arg Leu Pro Trp Ala Arg Leu Phe Gln Pro Ser 
145                 150                 155                 160 


Ile Gln Leu Ala Arg Gln Gly Phe Pro Val Gly Lys Gly Leu 
                165                 170                 


<210>  5915
<211>  569
<212>  PRT
<213>  Homo Sapiens

<400>  5915

Met Lys Lys Lys Leu Val Val Leu Gly Leu Leu Ala Val Val Leu Val 
1               5                   10                  15      


Leu Val Ile Val Gly Leu Cys Leu Trp Leu Pro Ser Ala Ser Lys Glu 
            20                  25                  30          


Pro Asp Asn His Val Tyr Thr Arg Ala Ala Val Ala Ala Asp Ala Lys 
        35                  40                  45              


Gln Cys Ser Lys Ile Gly Arg Asp Ala Leu Arg Asp Gly Gly Ser Ala 
    50                  55                  60                  


Val Asp Ala Ala Ile Ala Ala Leu Leu Cys Val Gly Leu Met Asn Ala 
65                  70                  75                  80  


His Ser Met Gly Ile Gly Gly Gly Leu Phe Leu Thr Ile Tyr Asn Ser 
                85                  90                  95      


Thr Thr Arg Lys Ala Glu Val Ile Asn Ala Arg Glu Val Ala Pro Arg 
            100                 105                 110         


Leu Ala Phe Ala Thr Met Phe Asn Ser Ser Glu Gln Ser Gln Lys Gly 
        115                 120                 125             


Gly Leu Ser Val Ala Val Pro Gly Glu Ile Arg Gly Tyr Glu Leu Ala 
    130                 135                 140                 


His Gln Arg His Gly Arg Leu Pro Trp Ala Arg Leu Phe Gln Pro Ser 
145                 150                 155                 160 


Ile Gln Leu Ala Arg Gln Gly Phe Pro Val Gly Lys Gly Leu Ala Ala 
                165                 170                 175     


Ala Leu Glu Asn Lys Arg Thr Val Ile Glu Gln Gln Pro Val Leu Cys 
            180                 185                 190         


Glu Val Phe Cys Arg Asp Arg Lys Val Leu Arg Glu Gly Glu Arg Leu 
        195                 200                 205             


Thr Leu Pro Gln Leu Ala Asp Thr Tyr Glu Thr Leu Ala Ile Glu Gly 
    210                 215                 220                 


Ala Gln Ala Phe Tyr Asn Gly Ser Leu Thr Ala Gln Ile Val Lys Asp 
225                 230                 235                 240 


Ile Gln Ala Ala Gly Gly Ile Val Thr Ala Glu Asp Leu Asn Asn Tyr 
                245                 250                 255     


Arg Ala Glu Leu Ile Glu His Pro Leu Asn Ile Ser Leu Gly Asp Val 
            260                 265                 270         


Val Leu Tyr Met Pro Ser Ala Pro Leu Ser Gly Pro Val Leu Ala Leu 
        275                 280                 285             


Ile Leu Asn Ile Leu Lys Gly Tyr Asn Phe Ser Arg Glu Ser Val Glu 
    290                 295                 300                 


Ser Pro Glu Gln Lys Gly Leu Thr Tyr His Arg Ile Val Glu Ala Phe 
305                 310                 315                 320 


Arg Phe Ala Tyr Ala Lys Arg Thr Leu Leu Gly Asp Pro Lys Phe Val 
                325                 330                 335     


Asp Val Thr Glu Val Val Arg Asn Met Thr Ser Glu Phe Phe Ala Ala 
            340                 345                 350         


Gln Leu Arg Ala Gln Ile Ser Asp Asp Thr Thr His Pro Ile Ser Tyr 
        355                 360                 365             


Tyr Lys Pro Glu Phe Tyr Thr Pro Asp Asp Gly Gly Thr Ala His Leu 
    370                 375                 380                 


Ser Val Val Ala Glu Asp Gly Ser Ala Val Ser Ala Thr Ser Thr Ile 
385                 390                 395                 400 


Asn Leu Tyr Phe Gly Ser Lys Val Arg Ser Pro Val Ser Gly Ile Leu 
                405                 410                 415     


Phe Asn Asn Glu Met Asp Asp Phe Ser Ser Pro Ser Ile Thr Asn Glu 
            420                 425                 430         


Phe Gly Val Pro Pro Ser Pro Ala Asn Phe Ile Gln Pro Gly Lys Gln 
        435                 440                 445             


Pro Leu Ser Ser Met Cys Pro Thr Ile Met Val Gly Gln Asp Gly Gln 
    450                 455                 460                 


Val Arg Met Val Val Gly Ala Ala Gly Gly Thr Gln Ile Thr Thr Ala 
465                 470                 475                 480 


Thr Ala Leu Ala Ile Ile Tyr Asn Leu Trp Phe Gly Tyr Asp Val Lys 
                485                 490                 495     


Arg Ala Val Glu Glu Pro Arg Leu His Asn Gln Leu Leu Pro Asn Val 
            500                 505                 510         


Thr Thr Val Glu Arg Asn Ile Asp Gln Ala Val Thr Ala Ala Leu Glu 
        515                 520                 525             


Thr Arg His His His Thr Gln Ile Ala Ser Thr Phe Ile Ala Val Val 
    530                 535                 540                 


Gln Ala Ile Val Arg Thr Ala Gly Gly Trp Ala Ala Ala Ser Asp Ser 
545                 550                 555                 560 


Arg Lys Gly Gly Glu Pro Ala Gly Tyr 
                565                 


<210>  5916
<211>  366
<212>  PRT
<213>  Homo Sapiens

<400>  5916

Met Lys Lys Lys Leu Val Val Leu Gly Leu Leu Ala Val Val Leu Val 
1               5                   10                  15      


Leu Val Ile Val Gly Leu Cys Leu Trp Leu Pro Ser Ala Ser Lys Glu 
            20                  25                  30          


Pro Asp Asn His Val Tyr Thr Arg Ala Ala Val Ala Ala Asp Ala Lys 
        35                  40                  45              


Gln Cys Ser Lys Ile Gly Arg Asp Ala Leu Arg Asp Gly Gly Ser Ala 
    50                  55                  60                  


Val Asp Ala Ala Ile Ala Ala Leu Leu Cys Val Gly Leu Met Asn Ala 
65                  70                  75                  80  


His Ser Met Gly Ile Gly Gly Gly Leu Phe Leu Thr Ile Tyr Asn Ser 
                85                  90                  95      


Thr Thr Arg Lys Ala Glu Val Ile Asn Ala Arg Glu Val Ala Pro Arg 
            100                 105                 110         


Leu Ala Phe Ala Thr Met Phe Asn Ser Ser Glu Gln Ser Gln Lys Gly 
        115                 120                 125             


Gly Leu Ser Val Ala Val Pro Gly Glu Ile Arg Gly Tyr Glu Leu Ala 
    130                 135                 140                 


His Gln Arg His Gly Arg Leu Pro Trp Ala Arg Leu Phe Gln Pro Ser 
145                 150                 155                 160 


Ile Gln Leu Ala Arg Gln Gly Phe Pro Val Gly Lys Gly Leu Ala Ala 
                165                 170                 175     


Ala Leu Glu Asn Lys Arg Thr Val Ile Glu Gln Gln Pro Val Leu Cys 
            180                 185                 190         


Glu Val Phe Cys Arg Asp Arg Lys Val Leu Arg Glu Gly Glu Arg Leu 
        195                 200                 205             


Thr Leu Pro Gln Leu Ala Asp Thr Tyr Glu Thr Leu Ala Ile Glu Gly 
    210                 215                 220                 


Ala Gln Ala Phe Tyr Asn Gly Ser Leu Thr Ala Gln Ile Val Lys Asp 
225                 230                 235                 240 


Ile Gln Ala Ala Gly Gly Ile Val Thr Ala Glu Asp Leu Asn Asn Tyr 
                245                 250                 255     


Arg Ala Glu Leu Ile Glu His Pro Leu Asn Ile Ser Leu Gly Asp Val 
            260                 265                 270         


Val Leu Tyr Met Pro Ser Ala Pro Leu Ser Gly Pro Val Leu Ala Leu 
        275                 280                 285             


Ile Leu Asn Ile Leu Lys Gly Tyr Asn Phe Ser Arg Glu Ser Val Glu 
    290                 295                 300                 


Ser Pro Glu Gln Lys Gly Leu Thr Tyr His Arg Ile Val Glu Ala Phe 
305                 310                 315                 320 


Arg Phe Ala Tyr Ala Lys Arg Thr Leu Leu Gly Asp Pro Lys Phe Val 
                325                 330                 335     


Asp Val Thr Glu Ala Ser Ser Gly Val Ser Ala Gly Gly Pro Gln His 
            340                 345                 350         


Asp Leu Arg Val Leu Arg Cys Pro Ala Pro Gly Pro Asp Leu 
        355                 360                 365     


<210>  5917
<211>  463
<212>  PRT
<213>  Homo Sapiens

<400>  5917

Met Lys Lys Lys Leu Val Val Leu Gly Leu Leu Ala Val Val Leu Val 
1               5                   10                  15      


Leu Val Ile Val Gly Leu Cys Leu Trp Leu Pro Ser Ala Ser Lys Glu 
            20                  25                  30          


Pro Asp Asn His Val Tyr Thr Arg Ala Ala Val Ala Ala Asp Ala Lys 
        35                  40                  45              


Gln Cys Ser Lys Ile Gly Arg Asp Ala Leu Arg Asp Gly Gly Ser Ala 
    50                  55                  60                  


Val Asp Ala Ala Ile Ala Ala Leu Leu Cys Val Gly Leu Met Asn Ala 
65                  70                  75                  80  


His Ser Met Gly Ile Gly Gly Gly Leu Phe Leu Thr Ile Tyr Asn Ser 
                85                  90                  95      


Thr Thr Arg Lys Ala Glu Val Ile Asn Ala Arg Glu Val Ala Pro Arg 
            100                 105                 110         


Leu Ala Phe Ala Thr Met Phe Asn Ser Ser Glu Gln Ser Gln Lys Gly 
        115                 120                 125             


Gly Leu Ser Val Ala Val Pro Gly Glu Ile Arg Gly Tyr Glu Leu Ala 
    130                 135                 140                 


His Gln Arg His Gly Arg Leu Pro Trp Ala Arg Leu Phe Gln Pro Ser 
145                 150                 155                 160 


Ile Gln Leu Ala Arg Gln Gly Phe Pro Val Gly Lys Gly Leu Ala Ala 
                165                 170                 175     


Ala Leu Glu Asn Lys Arg Thr Val Ile Glu Gln Gln Pro Val Leu Cys 
            180                 185                 190         


Glu Val Phe Cys Arg Asp Arg Lys Val Leu Arg Glu Gly Glu Arg Leu 
        195                 200                 205             


Thr Leu Pro Gln Leu Ala Asp Thr Tyr Glu Thr Leu Ala Ile Glu Gly 
    210                 215                 220                 


Ala Gln Ala Phe Tyr Asn Gly Ser Leu Thr Ala Gln Ile Val Lys Asp 
225                 230                 235                 240 


Ile Gln Ala Ala Gly Gly Ile Val Thr Ala Glu Asp Leu Asn Asn Tyr 
                245                 250                 255     


Arg Ala Glu Leu Ile Glu His Pro Leu Asn Ile Ser Leu Gly Asp Val 
            260                 265                 270         


Val Leu Tyr Met Pro Ser Ala Pro Leu Ser Gly Pro Val Leu Ala Leu 
        275                 280                 285             


Ile Leu Asn Ile Leu Lys Gly Tyr Asn Phe Ser Arg Glu Ser Val Glu 
    290                 295                 300                 


Ser Pro Glu Gln Lys Gly Leu Thr Tyr His Arg Ile Val Glu Ala Phe 
305                 310                 315                 320 


Arg Phe Ala Tyr Ala Lys Arg Thr Leu Leu Gly Asp Pro Lys Phe Val 
                325                 330                 335     


Asp Val Thr Glu Val Val Arg Asn Met Thr Ser Glu Phe Phe Ala Ala 
            340                 345                 350         


Gln Leu Arg Ala Gln Ile Ser Asp Asp Thr Thr His Pro Ile Ser Tyr 
        355                 360                 365             


Tyr Lys Pro Glu Phe Tyr Thr Pro Asp Asp Gly Gly Thr Ala His Leu 
    370                 375                 380                 


Ser Val Val Ala Glu Asp Gly Ser Ala Val Ser Ala Thr Ser Thr Ile 
385                 390                 395                 400 


Asn Leu Tyr Phe Gly Ser Lys Val Arg Ser Pro Val Ser Gly Ile Leu 
                405                 410                 415     


Phe Asn Asn Glu Met Asp Asp Phe Ser Ser Pro Ser Ile Thr Asn Glu 
            420                 425                 430         


Phe Gly Val Pro Pro Ser Pro Ala Asn Phe Ile Gln Pro Gly Lys Gln 
        435                 440                 445             


Pro Leu Ser Ser Met Cys Pro Thr Ile Met Val Gly Gln Asp Gly 
    450                 455                 460             


<210>  5918
<211>  569
<212>  PRT
<213>  Homo Sapiens

<400>  5918

Met Lys Lys Lys Leu Val Val Leu Gly Leu Leu Ala Val Val Leu Val 
1               5                   10                  15      


Leu Val Ile Val Gly Leu Cys Leu Trp Leu Pro Ser Ala Ser Lys Glu 
            20                  25                  30          


Pro Asp Asn His Val Tyr Thr Arg Ala Ala Val Ala Ala Asp Ala Lys 
        35                  40                  45              


Gln Cys Ser Lys Ile Gly Arg Asp Ala Leu Arg Asp Gly Gly Ser Ala 
    50                  55                  60                  


Val Asp Ala Ala Ile Ala Ala Leu Leu Cys Val Gly Leu Met Asn Ala 
65                  70                  75                  80  


His Ser Met Gly Ile Gly Gly Gly Leu Phe Leu Thr Ile Tyr Asn Ser 
                85                  90                  95      


Thr Thr Arg Lys Ala Glu Val Ile Asn Ala Arg Glu Val Ala Pro Arg 
            100                 105                 110         


Leu Ala Phe Ala Thr Met Phe Asn Ser Ser Glu Gln Ser Gln Lys Gly 
        115                 120                 125             


Gly Leu Ser Val Ala Val Pro Gly Glu Ile Arg Gly Tyr Glu Leu Ala 
    130                 135                 140                 


His Gln Arg His Gly Arg Leu Pro Trp Ala Arg Leu Phe Gln Pro Ser 
145                 150                 155                 160 


Ile Gln Leu Ala Arg Gln Gly Phe Pro Val Gly Lys Gly Leu Ala Ala 
                165                 170                 175     


Ala Leu Glu Asn Lys Arg Thr Val Ile Glu Gln Gln Pro Val Leu Cys 
            180                 185                 190         


Glu Val Phe Cys Arg Asp Arg Lys Val Leu Arg Glu Gly Glu Arg Leu 
        195                 200                 205             


Thr Leu Pro Gln Leu Ala Asp Thr Tyr Glu Thr Leu Ala Ile Glu Gly 
    210                 215                 220                 


Ala Gln Ala Phe Tyr Asn Gly Ser Leu Thr Ala Gln Ile Val Lys Asp 
225                 230                 235                 240 


Ile Gln Ala Ala Gly Gly Ile Val Thr Ala Glu Asp Leu Asn Asn Tyr 
                245                 250                 255     


Arg Ala Glu Leu Ile Glu His Pro Leu Asn Ile Ser Leu Gly Asp Val 
            260                 265                 270         


Val Leu Tyr Met Pro Ser Ala Pro Leu Ser Gly Pro Val Leu Ala Leu 
        275                 280                 285             


Ile Leu Asn Ile Leu Lys Gly Tyr Asn Phe Ser Arg Glu Ser Val Glu 
    290                 295                 300                 


Ser Pro Glu Gln Lys Gly Leu Thr Tyr His Arg Ile Val Glu Ala Phe 
305                 310                 315                 320 


Arg Phe Ala Tyr Ala Lys Arg Thr Leu Leu Gly Asp Pro Lys Phe Val 
                325                 330                 335     


Asp Val Thr Glu Val Val Arg Asn Met Thr Ser Glu Phe Phe Ala Ala 
            340                 345                 350         


Gln Leu Arg Ala Gln Ile Ser Asp Asp Thr Thr His Pro Ile Ser Tyr 
        355                 360                 365             


Tyr Lys Pro Glu Phe Tyr Thr Pro Asp Asp Gly Gly Thr Ala His Leu 
    370                 375                 380                 


Ser Val Val Ala Glu Asp Gly Ser Ala Val Ser Ala Thr Ser Thr Ile 
385                 390                 395                 400 


Asn Leu Tyr Phe Gly Ser Lys Val Arg Ser Pro Val Ser Gly Ile Leu 
                405                 410                 415     


Phe Asn Asn Glu Met Asp Asp Phe Ser Ser Pro Ser Ile Thr Asn Glu 
            420                 425                 430         


Phe Gly Val Pro Pro Ser Pro Ala Asn Phe Ile Gln Pro Gly Lys Gln 
        435                 440                 445             


Pro Leu Ser Ser Met Cys Pro Thr Ile Met Val Gly Gln Asp Gly Gln 
    450                 455                 460                 


Val Arg Met Val Val Gly Ala Ala Gly Gly Thr Gln Ile Thr Thr Ala 
465                 470                 475                 480 


Thr Ala Leu Ala Ile Ile Tyr Asn Leu Trp Phe Gly Tyr Asp Val Lys 
                485                 490                 495     


Arg Ala Val Glu Glu Pro Arg Leu His Asn Gln Leu Leu Pro Asn Val 
            500                 505                 510         


Thr Thr Val Glu Arg Asn Ile Asp Gln Ala Val Thr Ala Ala Leu Glu 
        515                 520                 525             


Thr Arg His His His Thr Gln Ile Ala Ser Thr Phe Ile Ala Val Val 
    530                 535                 540                 


Gln Ala Ile Val Arg Thr Ala Gly Gly Trp Ala Ala Ala Ser Asp Ser 
545                 550                 555                 560 


Arg Lys Gly Gly Glu Pro Ala Gly Tyr 
                565                 


<210>  5919
<211>  569
<212>  PRT
<213>  Homo Sapiens

<400>  5919

Met Lys Lys Lys Leu Val Val Leu Gly Leu Leu Ala Val Val Leu Val 
1               5                   10                  15      


Leu Val Ile Val Gly Leu Cys Leu Trp Leu Pro Ser Ala Ser Lys Glu 
            20                  25                  30          


Pro Asp Asn His Val Tyr Thr Arg Ala Ala Val Ala Ala Asp Ala Lys 
        35                  40                  45              


Gln Cys Ser Lys Ile Gly Arg Asp Ala Leu Arg Asp Gly Gly Ser Ala 
    50                  55                  60                  


Val Asp Ala Ala Ile Ala Ala Leu Leu Cys Val Gly Leu Met Asn Ala 
65                  70                  75                  80  


His Ser Met Gly Ile Gly Gly Gly Leu Phe Leu Thr Ile Tyr Asn Ser 
                85                  90                  95      


Thr Thr Arg Lys Ala Glu Val Ile Asn Ala Arg Glu Val Ala Pro Arg 
            100                 105                 110         


Leu Ala Phe Ala Thr Met Phe Asn Ser Ser Glu Gln Ser Gln Lys Gly 
        115                 120                 125             


Gly Leu Ser Val Ala Val Pro Gly Glu Ile Arg Gly Tyr Glu Leu Ala 
    130                 135                 140                 


His Gln Arg His Gly Arg Leu Pro Trp Ala Arg Leu Phe Gln Pro Ser 
145                 150                 155                 160 


Ile Gln Leu Ala Arg Gln Gly Phe Pro Val Gly Lys Gly Leu Ala Ala 
                165                 170                 175     


Ala Leu Glu Asn Lys Arg Thr Val Ile Glu Gln Gln Pro Val Leu Cys 
            180                 185                 190         


Glu Val Phe Cys Arg Asp Arg Lys Val Leu Arg Glu Gly Glu Arg Leu 
        195                 200                 205             


Thr Leu Pro Gln Leu Ala Asp Thr Tyr Glu Thr Leu Ala Ile Glu Gly 
    210                 215                 220                 


Ala Gln Ala Phe Tyr Asn Gly Ser Leu Thr Ala Gln Ile Val Lys Asp 
225                 230                 235                 240 


Ile Gln Ala Ala Gly Gly Ile Val Thr Ala Glu Asp Leu Asn Asn Tyr 
                245                 250                 255     


Arg Ala Glu Leu Ile Glu His Pro Leu Asn Ile Ser Leu Gly Asp Val 
            260                 265                 270         


Val Leu Tyr Met Pro Ser Ala Pro Leu Ser Gly Pro Val Leu Ala Leu 
        275                 280                 285             


Ile Leu Asn Ile Leu Lys Gly Tyr Asn Phe Ser Arg Glu Ser Val Glu 
    290                 295                 300                 


Ser Pro Glu Gln Lys Gly Leu Thr Tyr His Arg Ile Val Glu Ala Phe 
305                 310                 315                 320 


Arg Phe Ala Tyr Ala Lys Arg Thr Leu Leu Gly Asp Pro Lys Phe Val 
                325                 330                 335     


Asp Val Thr Glu Val Val Arg Asn Met Thr Ser Glu Phe Phe Ala Ala 
            340                 345                 350         


Gln Leu Arg Ala Gln Ile Ser Asp Asp Thr Thr His Pro Ile Ser Tyr 
        355                 360                 365             


Tyr Lys Pro Glu Phe Tyr Thr Pro Asp Asp Gly Gly Thr Ala His Leu 
    370                 375                 380                 


Ser Val Val Ala Glu Asp Gly Ser Ala Val Ser Ala Thr Ser Thr Ile 
385                 390                 395                 400 


Asn Leu Tyr Phe Gly Ser Lys Val Arg Ser Pro Val Ser Gly Ile Leu 
                405                 410                 415     


Phe Asn Asn Glu Met Asp Asp Phe Ser Ser Pro Ser Ile Thr Asn Glu 
            420                 425                 430         


Phe Gly Val Pro Pro Ser Pro Ala Asn Phe Ile Gln Pro Gly Lys Gln 
        435                 440                 445             


Pro Leu Ser Ser Met Cys Pro Thr Ile Met Val Gly Gln Asp Gly Gln 
    450                 455                 460                 


Val Arg Met Val Val Gly Ala Ala Gly Gly Thr Gln Ile Thr Thr Ala 
465                 470                 475                 480 


Thr Ala Leu Ala Ile Ile Tyr Asn Leu Trp Phe Gly Tyr Asp Val Lys 
                485                 490                 495     


Arg Ala Val Glu Glu Pro Arg Leu His Asn Gln Leu Leu Pro Asn Val 
            500                 505                 510         


Thr Thr Val Glu Arg Asn Ile Asp Gln Ala Val Thr Ala Ala Leu Glu 
        515                 520                 525             


Thr Arg His His His Thr Gln Ile Ala Ser Thr Phe Ile Ala Val Val 
    530                 535                 540                 


Gln Ala Ile Val Arg Thr Ala Gly Gly Trp Ala Ala Ala Ser Asp Ser 
545                 550                 555                 560 


Arg Lys Gly Gly Glu Pro Ala Gly Tyr 
                565                 


<210>  5920
<211>  218
<212>  PRT
<213>  Homo Sapiens

<400>  5920

Met Thr Ser Glu Phe Phe Ala Ala Gln Leu Arg Ala Gln Ile Ser Asp 
1               5                   10                  15      


Asp Thr Thr His Pro Ile Ser Tyr Tyr Lys Pro Glu Phe Tyr Thr Pro 
            20                  25                  30          


Asp Asp Gly Gly Thr Ala His Leu Ser Val Val Ala Glu Asp Gly Ser 
        35                  40                  45              


Ala Val Ser Ala Thr Ser Thr Ile Asn Leu Tyr Phe Gly Ser Lys Val 
    50                  55                  60                  


Arg Ser Pro Val Ser Gly Ile Leu Phe Asn Asn Glu Met Asp Asp Phe 
65                  70                  75                  80  


Ser Ser Pro Ser Ile Thr Asn Glu Phe Gly Val Pro Pro Ser Pro Ala 
                85                  90                  95      


Asn Phe Ile Gln Pro Gly Lys Gln Pro Leu Ser Ser Met Cys Pro Thr 
            100                 105                 110         


Ile Met Val Gly Gln Asp Gly Gln Pro Pro Ser His Ala Asp His Thr 
        115                 120                 125             


Pro Met Pro Gln Ala Ile Ile Tyr Asn Leu Trp Phe Gly Tyr Asp Val 
    130                 135                 140                 


Lys Arg Ala Val Glu Glu Pro Arg Leu His Asn Gln Leu Leu Pro Asn 
145                 150                 155                 160 


Val Thr Thr Val Glu Arg Asn Ile Asp Gln Ala Val Thr Ala Ala Leu 
                165                 170                 175     


Glu Thr Arg His His His Thr Gln Ile Ala Ser Thr Phe Ile Ala Val 
            180                 185                 190         


Val Gln Ala Ile Val Arg Thr Ala Gly Gly Trp Ala Ala Ala Ser Asp 
        195                 200                 205             


Ser Arg Lys Gly Gly Glu Pro Ala Gly Tyr 
    210                 215             


<210>  5921
<211>  225
<212>  PRT
<213>  Homo Sapiens

<400>  5921

Met Thr Ser Glu Phe Phe Ala Ala Gln Leu Arg Ala Gln Ile Ser Asp 
1               5                   10                  15      


Asp Thr Thr His Pro Ile Ser Tyr Tyr Lys Pro Glu Phe Tyr Thr Pro 
            20                  25                  30          


Asp Asp Gly Gly Thr Ala His Leu Ser Val Val Ala Glu Asp Gly Ser 
        35                  40                  45              


Ala Val Ser Ala Thr Ser Thr Ile Asn Leu Tyr Phe Gly Ser Lys Val 
    50                  55                  60                  


Arg Ser Pro Val Ser Gly Ile Leu Phe Asn Asn Glu Met Asp Asp Phe 
65                  70                  75                  80  


Ser Ser Pro Ser Ile Thr Asn Glu Phe Gly Val Pro Pro Ser Pro Ala 
                85                  90                  95      


Asn Phe Ile Gln Pro Gly Lys Gln Pro Leu Ser Ser Met Cys Pro Thr 
            100                 105                 110         


Ile Met Val Gly Gln Asp Gly Gln Val Arg Met Val Val Gly Ala Ala 
        115                 120                 125             


Gly Gly Thr Gln Ile Thr Thr Ala Thr Ala Leu Ala Ile Ile Tyr Asn 
    130                 135                 140                 


Leu Trp Phe Gly Tyr Asp Val Lys Arg Ala Val Glu Glu Pro Arg Leu 
145                 150                 155                 160 


His Asn Gln Leu Leu Pro Asn Val Thr Thr Val Glu Arg Asn Ile Asp 
                165                 170                 175     


Gln Ala Val Thr Ala Ala Leu Glu Thr Arg His His His Thr Gln Ile 
            180                 185                 190         


Ala Ser Thr Phe Ile Ala Val Val Gln Ala Ile Val Arg Thr Ala Gly 
        195                 200                 205             


Gly Trp Ala Ala Ala Ser Asp Ser Arg Lys Gly Gly Glu Pro Ala Gly 
    210                 215                 220                 


Tyr 
225 


<210>  5922
<211>  225
<212>  PRT
<213>  Homo Sapiens

<400>  5922

Met Thr Ser Glu Phe Phe Ala Ala Gln Leu Arg Ala Gln Ile Ser Asp 
1               5                   10                  15      


Asp Thr Thr His Pro Ile Ser Tyr Tyr Lys Pro Glu Phe Tyr Thr Pro 
            20                  25                  30          


Asp Asp Gly Gly Thr Ala His Leu Ser Val Val Ala Glu Asp Gly Ser 
        35                  40                  45              


Ala Val Ser Ala Thr Ser Thr Ile Asn Leu Tyr Phe Gly Ser Lys Val 
    50                  55                  60                  


Arg Ser Pro Val Ser Gly Ile Leu Phe Asn Asn Glu Met Asp Asp Phe 
65                  70                  75                  80  


Ser Ser Pro Ser Ile Thr Asn Glu Phe Gly Val Pro Pro Ser Pro Ala 
                85                  90                  95      


Asn Phe Ile Gln Pro Gly Lys Gln Pro Leu Ser Ser Met Cys Pro Thr 
            100                 105                 110         


Ile Met Val Gly Gln Asp Gly Gln Val Arg Met Val Val Gly Ala Ala 
        115                 120                 125             


Gly Gly Thr Gln Ile Thr Thr Ala Thr Ala Leu Ala Ile Ile Tyr Asn 
    130                 135                 140                 


Leu Trp Phe Gly Tyr Asp Val Lys Arg Ala Val Glu Glu Pro Arg Leu 
145                 150                 155                 160 


His Asn Gln Leu Leu Pro Asn Val Thr Thr Val Glu Arg Asn Ile Asp 
                165                 170                 175     


Gln Ala Val Thr Ala Ala Leu Glu Thr Arg His His His Thr Gln Ile 
            180                 185                 190         


Ala Ser Thr Phe Ile Ala Val Val Gln Ala Ile Val Arg Thr Ala Gly 
        195                 200                 205             


Gly Trp Ala Ala Ala Ser Asp Ser Arg Lys Gly Gly Glu Pro Ala Gly 
    210                 215                 220                 


Tyr 
225 


<210>  5923
<211>  225
<212>  PRT
<213>  Homo Sapiens

<400>  5923

Met Thr Ser Glu Phe Phe Ala Ala Gln Leu Arg Ala Gln Ile Ser Asp 
1               5                   10                  15      


Asp Thr Thr His Pro Ile Ser Tyr Tyr Lys Pro Glu Phe Tyr Thr Pro 
            20                  25                  30          


Asp Asp Gly Gly Thr Ala His Leu Ser Val Val Ala Glu Asp Gly Ser 
        35                  40                  45              


Ala Val Ser Ala Thr Ser Thr Ile Asn Leu Tyr Phe Gly Ser Lys Val 
    50                  55                  60                  


Arg Ser Pro Val Ser Gly Ile Leu Phe Asn Asn Glu Met Asp Asp Phe 
65                  70                  75                  80  


Ser Ser Pro Ser Ile Thr Asn Glu Phe Gly Val Pro Pro Ser Pro Ala 
                85                  90                  95      


Asn Phe Ile Gln Pro Gly Lys Gln Pro Leu Ser Ser Met Cys Pro Thr 
            100                 105                 110         


Ile Met Val Gly Gln Asp Gly Gln Val Arg Met Val Val Gly Ala Ala 
        115                 120                 125             


Gly Gly Thr Gln Ile Thr Thr Ala Thr Ala Leu Ala Ile Ile Tyr Asn 
    130                 135                 140                 


Leu Trp Phe Gly Tyr Asp Val Lys Arg Ala Val Glu Glu Pro Arg Leu 
145                 150                 155                 160 


His Asn Gln Leu Leu Pro Asn Val Thr Thr Val Glu Arg Asn Ile Asp 
                165                 170                 175     


Gln Ala Val Thr Ala Ala Leu Glu Thr Arg His His His Thr Gln Ile 
            180                 185                 190         


Ala Ser Thr Phe Ile Ala Val Val Gln Ala Ile Val Arg Thr Ala Gly 
        195                 200                 205             


Gly Trp Ala Ala Ala Ser Asp Ser Arg Lys Gly Gly Glu Pro Ala Gly 
    210                 215                 220                 


Tyr 
225 


<210>  5924
<211>  252
<212>  PRT
<213>  Homo Sapiens

<400>  5924

Met Thr Ser Glu Phe Phe Ala Ala Gln Leu Arg Ala Gln Ile Ser Asp 
1               5                   10                  15      


Asp Thr Thr His Pro Ile Ser Tyr Tyr Lys Pro Glu Phe Tyr Thr Pro 
            20                  25                  30          


Asp Asp Gly Gly Thr Ala His Leu Ser Val Val Ala Glu Asp Gly Ser 
        35                  40                  45              


Ala Val Ser Ala Thr Ser Thr Ile Asn Leu Tyr Phe Gly Ser Lys Val 
    50                  55                  60                  


Arg Ser Pro Val Ser Gly Ile Leu Phe Asn Asn Glu Met Asp Asp Phe 
65                  70                  75                  80  


Ser Ser Pro Ser Ile Thr Asn Glu Phe Gly Val Pro Pro Ser Pro Ala 
                85                  90                  95      


Asn Phe Ile Gln Pro Gly Lys Gln Pro Leu Ser Ser Met Cys Pro Thr 
            100                 105                 110         


Ile Met Val Gly Gln Asp Gly Gln Val Arg Met Val Val Gly Ala Ala 
        115                 120                 125             


Gly Gly Thr Gln Ile Thr Thr Ala Thr Ala Leu Val Cys Val Thr Pro 
    130                 135                 140                 


Phe Leu Pro Gly Arg Ala His Pro Ala Gln Pro Pro Ser His Ala Asp 
145                 150                 155                 160 


His Thr Pro Met Pro Gln Ala Ile Ile Tyr Asn Leu Trp Phe Gly Tyr 
                165                 170                 175     


Asp Val Lys Arg Ala Val Glu Glu Pro Arg Leu His Asn Gln Leu Leu 
            180                 185                 190         


Pro Asn Val Thr Thr Val Glu Arg Asn Ile Asp Gln Ala Val Thr Ala 
        195                 200                 205             


Ala Leu Glu Thr Arg His His His Thr Gln Ile Ala Ser Thr Phe Ile 
    210                 215                 220                 


Ala Val Val Gln Ala Ile Val Arg Thr Ala Gly Gly Trp Ala Ala Ala 
225                 230                 235                 240 


Ser Asp Ser Arg Lys Gly Gly Glu Pro Ala Gly Tyr 
                245                 250         


<210>  5925
<211>  554
<212>  PRT
<213>  Homo Sapiens

<400>  5925

Met Ala Arg Gly Tyr Gly Ala Thr Val Ser Leu Val Leu Leu Gly Leu 
1               5                   10                  15      


Gly Leu Ala Leu Ala Val Ile Val Leu Ala Val Val Leu Ser Arg His 
            20                  25                  30          


Gln Ala Pro Cys Gly Pro Gln Ala Phe Ala His Ala Ala Val Ala Ala 
        35                  40                  45              


Asp Ser Lys Val Cys Ser Asp Ile Gly Arg Ala Ile Leu Gln Gln Gln 
    50                  55                  60                  


Gly Ser Pro Val Asp Ala Thr Ile Ala Ala Leu Val Cys Thr Ser Val 
65                  70                  75                  80  


Val Asn Pro Gln Ser Met Gly Leu Gly Gly Gly Val Ile Phe Thr Ile 
                85                  90                  95      


Tyr Asn Val Thr Thr Gly Ala Gln Trp Ile Gly Val Pro Gly Glu Leu 
            100                 105                 110         


Arg Gly Tyr Ala Glu Ala His Arg Arg His Gly Arg Leu Pro Trp Ala 
        115                 120                 125             


Gln Leu Phe Gln Pro Thr Ile Ala Leu Leu Arg Gly Gly His Val Val 
    130                 135                 140                 


Ala Pro Val Leu Ser Arg Phe Leu His Asn Ser Ile Leu Arg Pro Ser 
145                 150                 155                 160 


Leu Gln Ala Ser Thr Leu Arg Gln Leu Phe Phe Asn Gly Thr Glu Pro 
                165                 170                 175     


Leu Arg Pro Gln Asp Pro Leu Pro Trp Pro Ala Leu Ala Thr Thr Leu 
            180                 185                 190         


Glu Thr Val Ala Thr Glu Gly Val Glu Val Phe Tyr Thr Gly Arg Leu 
        195                 200                 205             


Gly Gln Met Leu Val Glu Asp Ile Ala Lys Glu Gly Ser Gln Leu Thr 
    210                 215                 220                 


Leu Gln Asp Leu Ala Lys Phe Gln Pro Glu Val Val Asp Ala Leu Glu 
225                 230                 235                 240 


Val Pro Leu Gly Asp Tyr Thr Leu Tyr Ser Pro Pro Pro Pro Ala Gly 
                245                 250                 255     


Gly Ala Ile Leu Ser Phe Ile Leu Asn Val Leu Arg Gly Phe Asn Phe 
            260                 265                 270         


Ser Thr Glu Ser Met Ala Arg Pro Glu Gly Arg Val Asn Val Tyr His 
        275                 280                 285             


His Leu Val Glu Thr Leu Lys Phe Ala Lys Gly Gln Arg Trp Arg Leu 
    290                 295                 300                 


Gly Asp Pro Arg Ser His Pro Lys Leu Gln Asn Ala Ser Arg Asp Leu 
305                 310                 315                 320 


Leu Gly Glu Thr Leu Ala Gln Leu Ile Arg Gln Gln Ile Asp Gly Arg 
                325                 330                 335     


Gly Asp His Gln Leu Ser His Tyr Ser Leu Ala Glu Ala Trp Gly His 
            340                 345                 350         


Gly Thr Gly Thr Ser His Val Ser Val Leu Gly Glu Asp Gly Ser Ala 
        355                 360                 365             


Val Ala Ala Thr Ser Thr Ile Asn Thr Pro Phe Gly Ala Met Val Tyr 
    370                 375                 380                 


Ser Pro Arg Thr Gly Ile Ile Leu Asn Asn Glu Leu Leu Asp Leu Cys 
385                 390                 395                 400 


Glu Arg Cys Pro Arg Gly Ser Gly Thr Thr Pro Ser Pro Val Ser Gly 
                405                 410                 415     


Asp Arg Val Gly Gly Ala Pro Gly Arg Cys Trp Pro Pro Val Pro Gly 
            420                 425                 430         


Glu Arg Ser Pro Ser Ser Met Val Pro Ser Ile Leu Ile Asn Lys Ala 
        435                 440                 445             


Gln Gly Ser Lys Leu Val Ile Gly Gly Ala Gly Gly Glu Leu Ile Ile 
    450                 455                 460                 


Ser Ala Val Ala Gln Ala Ile Met Ser Lys Leu Trp Leu Gly Phe Asp 
465                 470                 475                 480 


Leu Arg Ala Ala Ile Ala Ala Pro Ile Leu His Val Asn Ser Lys Gly 
                485                 490                 495     


Cys Val Glu Tyr Glu Pro Asn Phe Ser Gln Glu Val Gln Arg Gly Leu 
            500                 505                 510         


Gln Asp Arg Gly Gln Asn Gln Thr Gln Arg Pro Phe Phe Leu Asn Val 
        515                 520                 525             


Val Gln Ala Val Ser Gln Glu Gly Ala Cys Val Tyr Ala Val Ser Asp 
    530                 535                 540                 


Leu Arg Lys Ser Gly Glu Ala Ala Gly Tyr 
545                 550                 


<210>  5926
<211>  586
<212>  PRT
<213>  Homo Sapiens

<400>  5926

Met Ala Arg Gly Tyr Gly Ala Thr Val Ser Leu Val Leu Leu Gly Leu 
1               5                   10                  15      


Gly Leu Ala Leu Ala Val Ile Val Leu Ala Val Val Leu Ser Arg His 
            20                  25                  30          


Gln Ala Pro Cys Gly Pro Gln Ala Phe Ala His Ala Ala Val Ala Ala 
        35                  40                  45              


Asp Ser Lys Val Cys Ser Asp Ile Gly Arg Ala Ile Leu Gln Gln Gln 
    50                  55                  60                  


Gly Ser Pro Val Asp Ala Thr Ile Ala Ala Leu Val Cys Thr Ser Val 
65                  70                  75                  80  


Val Asn Pro Gln Ser Met Gly Leu Gly Gly Gly Val Ile Phe Thr Ile 
                85                  90                  95      


Tyr Asn Val Thr Thr Gly Lys Val Glu Val Ile Asn Ala Arg Glu Thr 
            100                 105                 110         


Val Pro Ala Ser His Ala Pro Ser Leu Leu Asp Gln Cys Ala Gln Ala 
        115                 120                 125             


Leu Pro Leu Gly Thr Gly Ala Gln Trp Ile Gly Val Pro Gly Glu Leu 
    130                 135                 140                 


Arg Gly Tyr Ala Glu Ala His Arg Arg His Gly Arg Leu Pro Trp Ala 
145                 150                 155                 160 


Gln Leu Phe Gln Pro Thr Ile Ala Leu Leu Arg Gly Gly His Val Val 
                165                 170                 175     


Ala Pro Val Leu Ser Arg Phe Leu His Asn Ser Ile Leu Arg Pro Ser 
            180                 185                 190         


Leu Gln Ala Ser Thr Leu Arg Gln Leu Phe Phe Asn Gly Thr Glu Pro 
        195                 200                 205             


Leu Arg Pro Gln Asp Pro Leu Pro Trp Pro Ala Leu Ala Thr Thr Leu 
    210                 215                 220                 


Glu Thr Val Ala Thr Glu Gly Val Glu Val Phe Tyr Thr Gly Arg Leu 
225                 230                 235                 240 


Gly Gln Met Leu Val Glu Asp Ile Ala Lys Glu Gly Ser Gln Leu Thr 
                245                 250                 255     


Leu Gln Asp Leu Ala Lys Phe Gln Pro Glu Val Val Asp Ala Leu Glu 
            260                 265                 270         


Val Pro Leu Gly Asp Tyr Thr Leu Tyr Ser Pro Pro Pro Pro Ala Gly 
        275                 280                 285             


Gly Ala Ile Leu Ser Phe Ile Leu Asn Val Leu Arg Gly Phe Asn Phe 
    290                 295                 300                 


Ser Thr Glu Ser Met Ala Arg Pro Glu Gly Arg Val Asn Val Tyr His 
305                 310                 315                 320 


His Leu Val Glu Thr Leu Lys Phe Ala Lys Gly Gln Arg Trp Arg Leu 
                325                 330                 335     


Gly Asp Pro Arg Ser His Pro Lys Leu Gln Asn Ala Ser Arg Asp Leu 
            340                 345                 350         


Leu Gly Glu Thr Leu Ala Gln Leu Ile Arg Gln Gln Ile Asp Gly Arg 
        355                 360                 365             


Gly Asp His Gln Leu Ser His Tyr Ser Leu Ala Glu Ala Trp Gly His 
    370                 375                 380                 


Gly Thr Gly Thr Ser His Val Ser Val Leu Gly Glu Asp Gly Ser Ala 
385                 390                 395                 400 


Val Ala Ala Thr Ser Thr Ile Asn Thr Pro Phe Gly Ala Met Val Tyr 
                405                 410                 415     


Ser Pro Arg Thr Gly Ile Ile Leu Asn Asn Glu Leu Leu Asp Leu Cys 
            420                 425                 430         


Glu Arg Cys Pro Arg Gly Ser Gly Thr Thr Pro Ser Pro Val Ser Gly 
        435                 440                 445             


Asp Arg Val Gly Gly Ala Pro Gly Arg Cys Trp Pro Pro Val Pro Gly 
    450                 455                 460                 


Glu Arg Ser Pro Ser Ser Met Val Pro Ser Ile Leu Ile Asn Lys Ala 
465                 470                 475                 480 


Gln Gly Ser Lys Leu Val Ile Gly Gly Ala Gly Gly Glu Leu Ile Ile 
                485                 490                 495     


Ser Ala Val Ala Gln Ala Ile Met Ser Lys Leu Trp Leu Gly Phe Asp 
            500                 505                 510         


Leu Arg Ala Ala Ile Ala Ala Pro Ile Leu His Val Asn Ser Lys Gly 
        515                 520                 525             


Cys Val Glu Tyr Glu Pro Asn Phe Ser Gln Glu Val Gln Arg Gly Leu 
    530                 535                 540                 


Gln Asp Arg Gly Gln Asn Gln Thr Gln Arg Pro Phe Phe Leu Asn Val 
545                 550                 555                 560 


Val Gln Ala Val Ser Gln Glu Gly Ala Cys Val Tyr Ala Val Ser Asp 
                565                 570                 575     


Leu Arg Lys Ser Gly Glu Ala Ala Gly Tyr 
            580                 585     


<210>  5927
<211>  587
<212>  PRT
<213>  Homo Sapiens

<400>  5927

Met Ala Arg Gly Tyr Gly Ala Thr Val Ser Leu Val Leu Leu Gly Leu 
1               5                   10                  15      


Gly Leu Ala Leu Ala Val Ile Val Leu Ala Val Val Leu Ser Arg His 
            20                  25                  30          


Gln Ala Pro Cys Gly Pro Gln Ala Phe Ala His Ala Ala Val Ala Ala 
        35                  40                  45              


Asp Ser Lys Val Cys Ser Asp Ile Gly Arg Ala Ile Leu Gln Gln Gln 
    50                  55                  60                  


Gly Ser Pro Val Asp Ala Thr Ile Ala Ala Leu Val Cys Thr Ser Val 
65                  70                  75                  80  


Val Asn Pro Gln Ser Met Gly Leu Gly Gly Gly Val Ile Phe Thr Ile 
                85                  90                  95      


Tyr Asn Val Thr Thr Gly Lys Val Glu Val Ile Asn Ala Arg Glu Thr 
            100                 105                 110         


Val Pro Ala Ser His Ala Pro Ser Leu Leu Asp Gln Cys Ala Gln Ala 
        115                 120                 125             


Leu Pro Leu Gly Thr Gly Ala Gln Trp Ile Gly Val Pro Gly Glu Leu 
    130                 135                 140                 


Arg Gly Tyr Ala Glu Ala His Arg Arg His Gly Arg Leu Pro Trp Ala 
145                 150                 155                 160 


Gln Leu Phe Gln Pro Thr Ile Ala Leu Leu Arg Gly Gly His Val Val 
                165                 170                 175     


Ala Pro Val Leu Ser Arg Phe Leu His Asn Ser Ile Leu Arg Pro Ser 
            180                 185                 190         


Leu Gln Ala Ser Thr Leu Arg Gln Leu Phe Phe Asn Gly Thr Glu Pro 
        195                 200                 205             


Leu Arg Pro Gln Asp Pro Leu Pro Trp Pro Ala Leu Ala Thr Thr Leu 
    210                 215                 220                 


Glu Thr Val Ala Thr Glu Gly Val Glu Val Phe Tyr Thr Gly Arg Leu 
225                 230                 235                 240 


Gly Gln Met Leu Val Glu Asp Ile Ala Lys Glu Gly Ser Gln Leu Thr 
                245                 250                 255     


Leu Gln Asp Leu Ala Lys Phe Gln Pro Glu Val Val Asp Ala Leu Glu 
            260                 265                 270         


Val Pro Leu Gly Asp Tyr Thr Leu Tyr Ser Pro Pro Pro Pro Ala Gly 
        275                 280                 285             


Gly Ala Ile Leu Ser Phe Ile Leu Asn Val Leu Arg Gly Phe Asn Phe 
    290                 295                 300                 


Ser Thr Glu Ser Met Ala Arg Pro Glu Gly Arg Val Asn Val Tyr His 
305                 310                 315                 320 


His Leu Val Glu Thr Leu Lys Phe Ala Lys Gly Gln Arg Trp Arg Leu 
                325                 330                 335     


Gly Asp Pro Arg Ser His Pro Lys Leu Gln Asn Ala Ser Arg Asp Leu 
            340                 345                 350         


Leu Gly Glu Thr Leu Ala Gln Leu Ile Arg Gln Gln Ile Asp Gly Arg 
        355                 360                 365             


Gly Asp His Gln Leu Ser His Tyr Ser Leu Ala Glu Ala Trp Gly His 
    370                 375                 380                 


Gly Thr Gly Thr Ser His Val Ser Val Leu Gly Glu Asp Gly Ser Ala 
385                 390                 395                 400 


Val Ala Ala Thr Ser Thr Ile Asn Thr Pro Phe Gly Ala Met Val Tyr 
                405                 410                 415     


Ser Pro Arg Thr Gly Ile Ile Leu Asn Asn Glu Leu Leu Asp Leu Cys 
            420                 425                 430         


Glu Arg Cys Pro Arg Gly Ser Gly Thr Thr Pro Ser Pro Ala Val Ser 
        435                 440                 445             


Gly Asp Arg Val Gly Gly Ala Pro Gly Arg Cys Trp Pro Pro Val Pro 
    450                 455                 460                 


Gly Glu Arg Ser Pro Ser Ser Met Val Pro Ser Ile Leu Ile Asn Lys 
465                 470                 475                 480 


Ala Gln Gly Ser Lys Leu Val Ile Gly Gly Ala Gly Gly Glu Leu Ile 
                485                 490                 495     


Ile Ser Ala Val Ala Gln Ala Ile Met Ser Lys Leu Trp Leu Gly Phe 
            500                 505                 510         


Asp Leu Arg Ala Ala Ile Ala Ala Pro Ile Leu His Val Asn Ser Lys 
        515                 520                 525             


Gly Cys Val Glu Tyr Glu Pro Asn Phe Ser Gln Glu Val Gln Arg Gly 
    530                 535                 540                 


Leu Gln Asp Arg Gly Gln Asn Gln Thr Gln Arg Pro Phe Phe Leu Asn 
545                 550                 555                 560 


Val Val Gln Ala Val Ser Gln Glu Gly Ala Cys Val Tyr Ala Val Ser 
                565                 570                 575     


Asp Leu Arg Lys Ser Gly Glu Ala Ala Gly Tyr 
            580                 585         


<210>  5928
<211>  73
<212>  PRT
<213>  Homo Sapiens

<400>  5928

Met Ala Arg Gly Tyr Gly Ala Thr Val Ser Leu Val Leu Leu Gly Leu 
1               5                   10                  15      


Gly Leu Ala Leu Ala Val Ile Val Leu Ala Val Val Leu Ser Arg His 
            20                  25                  30          


Gln Ala Pro Cys Gly Pro Gln Ala Phe Ala His Ala Ala Val Ala Ala 
        35                  40                  45              


Asp Ser Lys Val Cys Ser Asp Ile Gly Arg Gly Pro Val Asp Arg Gly 
    50                  55                  60                  


Ala Arg Gly Ala Pro Trp Leu Cys Arg 
65                  70              


<210>  5929
<211>  220
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5929

Xaa Ser Ala Val Ala Ala Thr Ser Thr Ile Asn Thr Pro Phe Gly Ala 
1               5                   10                  15      


Met Val Tyr Ser Pro Arg Thr Gly Ile Ile Leu Asn Asn Glu Leu Leu 
            20                  25                  30          


Asp Leu Cys Glu Arg Cys Pro Arg Gly Ser Gly Thr Thr Pro Ser Pro 
        35                  40                  45              


Val Ser Gly Asp Arg Val Gly Gly Ala Pro Gly Arg Cys Trp Pro Pro 
    50                  55                  60                  


Val Pro Gly Glu Arg Ser Pro Ser Ser Met Val Pro Ser Ile Leu Ile 
65                  70                  75                  80  


Asn Lys Ala Gln Gly Ser Lys Leu Val Ile Gly Gly Ala Gly Gly Glu 
                85                  90                  95      


Leu Ile Ile Ser Ala Val Ala Gln Ala Ile Met Ser Lys Leu Trp Leu 
            100                 105                 110         


Gly Phe Asp Leu Arg Ala Ala Ile Ala Ala Pro Ile Leu His Val Asn 
        115                 120                 125             


Ser Lys Gly Cys Val Glu Tyr Glu Pro Asn Phe Ser Gln Lys Gln Asp 
    130                 135                 140                 


Leu Ala Ala Leu Pro Arg Leu Val Ser Asn Ser Trp Pro Gln Val Ile 
145                 150                 155                 160 


Leu Leu Pro Gln Pro Pro Lys Leu Leu Ala Leu Gln Glu Val Gln Arg 
                165                 170                 175     


Gly Leu Gln Asp Arg Gly Gln Asn Gln Thr Gln Arg Pro Phe Phe Leu 
            180                 185                 190         


Asn Val Val Gln Ala Val Ser Gln Glu Gly Ala Cys Val Tyr Ala Val 
        195                 200                 205             


Ser Asp Leu Arg Lys Ser Gly Glu Ala Ala Gly Tyr 
    210                 215                 220 


<210>  5930
<211>  30
<212>  PRT
<213>  Homo Sapiens

<400>  5930

Met Ala Thr Glu Ala Gly Arg Trp Gln Pro Pro Asp Trp Ala Asp Leu 
1               5                   10                  15      


Gln Ala Asp Leu Gln Gln Val Arg His Lys Leu Thr Gln Arg 
            20                  25                  30  


<210>  5931
<211>  217
<212>  PRT
<213>  Homo Sapiens

<400>  5931

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Phe Pro Thr Ile Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His Arg Leu His Gln 
        35                  40                  45              


Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys 
    50                  55                  60                  


Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe 
65                  70                  75                  80  


Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp 
            100                 105                 110         


Leu Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala Asn Ser Leu Val 
        115                 120                 125             


Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Pro Arg 
145                 150                 155                 160 


Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser 
                165                 170                 175     


His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe 
            180                 185                 190         


Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Ile Val Gln Cys 
        195                 200                 205             


Arg Ser Val Glu Gly Ser Cys Gly Phe 
    210                 215         


<210>  5932
<211>  177
<212>  PRT
<213>  Homo Sapiens

<400>  5932

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Phe Pro Thr Ile Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His Arg Leu His Gln 
        35                  40                  45              


Leu Ala Phe Asp Thr Tyr Gln Glu Phe Asn Leu Glu Leu Leu Arg Ile 
    50                  55                  60                  


Ser Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg 
65                  70                  75                  80  


Ser Val Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val 
                85                  90                  95      


Tyr Asp Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly 
            100                 105                 110         


Arg Leu Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr 
        115                 120                 125             


Tyr Ser Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys 
    130                 135                 140                 


Asn Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu 
145                 150                 155                 160 


Thr Phe Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly 
                165                 170                 175     


Phe 
    


<210>  5933
<211>  202
<212>  PRT
<213>  Homo Sapiens

<400>  5933

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Phe Pro Thr Ile Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His Arg Leu His Gln 
        35                  40                  45              


Leu Ala Phe Asp Thr Tyr Gln Glu Phe Asn Pro Gln Thr Ser Leu Cys 
    50                  55                  60                  


Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu Thr Gln Gln 
65                  70                  75                  80  


Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser 
                85                  90                  95      


Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala Asn Ser Leu 
            100                 105                 110         


Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu Lys Asp Leu 
        115                 120                 125             


Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Pro 
    130                 135                 140                 


Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn 
145                 150                 155                 160 


Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys 
                165                 170                 175     


Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Ile Val Gln 
            180                 185                 190         


Cys Arg Ser Val Glu Gly Ser Cys Gly Phe 
        195                 200         


<210>  5934
<211>  122
<212>  PRT
<213>  Homo Sapiens

<400>  5934

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Phe Pro Thr Ile Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His Arg Leu His Gln 
        35                  40                  45              


Leu Ala Phe Asp Thr Tyr Gln Glu Phe Arg Leu Glu Asp Gly Ser Pro 
    50                  55                  60                  


Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn 
65                  70                  75                  80  


Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys 
                85                  90                  95      


Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Ile Val Gln 
            100                 105                 110         


Cys Arg Ser Val Glu Gly Ser Cys Gly Phe 
        115                 120         


<210>  5935
<211>  245
<212>  PRT
<213>  Homo Sapiens

<400>  5935

Met Ala Ala Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Ser Trp Leu Gln Glu Gly Ser Ala Phe Pro Thr Ile Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala Arg Arg Leu Tyr Gln 
        35                  40                  45              


Leu Ala Tyr Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Leu Lys 
    50                  55                  60                  


Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe 
65                  70                  75                  80  


Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Val Lys Thr Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp 
            100                 105                 110         


Leu Glu Pro Val Gln Leu Leu Arg Ser Val Phe Ala Asn Ser Leu Val 
        115                 120                 125             


Tyr Gly Ala Ser Asp Ser Asn Val Tyr Arg His Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Thr Leu Ile Gly Trp Lys Met Ala Ala Pro Gly Leu 
145                 150                 155                 160 


Gly Arg Ser Ser Ile Ser Pro Thr Ala Ser Leu Thr Gln Asn Arg Thr 
                165                 170                 175     


Thr Met Thr His Cys Ser Arg Thr Thr Gly Cys Ser Thr Ala Ser Gly 
            180                 185                 190         


Arg Thr Trp Thr Arg Ser Arg His Ser Cys Ala Ser Cys Ser Ala Ala 
        195                 200                 205             


Leu Trp Arg Ala Ala Val Ala Ser Ser Cys Pro Gly Gly Ile Pro Val 
    210                 215                 220                 


Thr Pro Pro Gln Cys Leu Ser Trp Ser Trp Lys Val Leu Leu Gln Cys 
225                 230                 235                 240 


Pro Pro Ala Leu Ser 
                245 


<210>  5936
<211>  217
<212>  PRT
<213>  Homo Sapiens

<400>  5936

Met Ala Ala Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Ser Trp Leu Gln Glu Gly Ser Ala Phe Pro Thr Ile Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala Arg Arg Leu Tyr Gln 
        35                  40                  45              


Leu Ala Tyr Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Leu Lys 
    50                  55                  60                  


Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe 
65                  70                  75                  80  


Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Val Lys Thr Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp 
            100                 105                 110         


Leu Glu Pro Val Gln Leu Leu Arg Ser Val Phe Ala Asn Ser Leu Val 
        115                 120                 125             


Tyr Gly Ala Ser Asp Ser Asn Val Tyr Arg His Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Thr Leu Met Trp Arg Leu Glu Asp Gly Ser Pro Arg 
145                 150                 155                 160 


Thr Gly Gln Ile Phe Asn Gln Ser Tyr Ser Lys Phe Asp Thr Lys Ser 
                165                 170                 175     


His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe 
            180                 185                 190         


Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Ile Val Gln Cys 
        195                 200                 205             


Arg Ser Val Glu Gly Ser Cys Gly Phe 
    210                 215         


<210>  5937
<211>  256
<212>  PRT
<213>  Homo Sapiens

<400>  5937

Met Ala Ala Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Ser Trp Leu Gln Glu Gly Ser Ala Phe Pro Thr Ile Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala Arg Arg Leu Tyr Gln 
        35                  40                  45              


Leu Ala Tyr Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Leu Lys 
    50                  55                  60                  


Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe 
65                  70                  75                  80  


Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Val Lys Thr Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp 
            100                 105                 110         


Leu Glu Pro Val Gln Leu Leu Arg Ser Val Phe Ala Asn Ser Leu Val 
        115                 120                 125             


Tyr Gly Ala Ser Asp Ser Asn Val Tyr Arg His Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Thr Leu Met Trp Val Arg Val Ala Pro Gly Ile Pro 
145                 150                 155                 160 


Asn Pro Gly Ala Pro Leu Ala Ser Arg Asp Trp Gly Glu Lys His Cys 
                165                 170                 175     


Cys Pro Leu Phe Ser Ser Gln Ala Leu Thr Gln Glu Asn Ser Pro Tyr 
            180                 185                 190         


Ser Ser Phe Pro Leu Val Asn Pro Pro Gly Leu Ser Leu Gln Pro Gly 
        195                 200                 205             


Gly Glu Gly Gly Lys Trp Met Asn Glu Arg Gly Arg Glu Gln Cys Pro 
    210                 215                 220                 


Ser Ala Trp Pro Leu Leu Leu Phe Leu His Phe Ala Glu Ala Gly Arg 
225                 230                 235                 240 


Trp Gln Pro Pro Asp Trp Ala Asp Leu Gln Ser Val Leu Gln Gln Val 
                245                 250                 255     


<210>  5938
<211>  177
<212>  PRT
<213>  Homo Sapiens

<400>  5938

Met Ala Ala Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Ser Trp Leu Gln Glu Gly Ser Ala Phe Pro Thr Ile Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala Arg Arg Leu Tyr Gln 
        35                  40                  45              


Leu Ala Tyr Asp Thr Tyr Gln Glu Phe Asn Leu Glu Leu Leu Arg Ile 
    50                  55                  60                  


Ser Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Leu Leu Arg 
65                  70                  75                  80  


Ser Val Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val 
                85                  90                  95      


Tyr Arg His Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Trp 
            100                 105                 110         


Arg Leu Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Asn Gln Ser 
        115                 120                 125             


Tyr Ser Lys Phe Asp Thr Lys Ser His Asn Asp Asp Ala Leu Leu Lys 
    130                 135                 140                 


Asn Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu 
145                 150                 155                 160 


Thr Phe Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly 
                165                 170                 175     


Phe 
    


<210>  5939
<211>  202
<212>  PRT
<213>  Homo Sapiens

<400>  5939

Met Ala Ala Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Ser Trp Leu Gln Glu Gly Ser Ala Phe Pro Thr Ile Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala Arg Arg Leu Tyr Gln 
        35                  40                  45              


Leu Ala Tyr Asp Thr Tyr Gln Glu Phe Asn Pro Gln Thr Ser Leu Cys 
    50                  55                  60                  


Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Val Lys Thr Gln Gln 
65                  70                  75                  80  


Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser 
                85                  90                  95      


Trp Leu Glu Pro Val Gln Leu Leu Arg Ser Val Phe Ala Asn Ser Leu 
            100                 105                 110         


Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Arg His Leu Lys Asp Leu 
        115                 120                 125             


Glu Glu Gly Ile Gln Thr Leu Met Trp Arg Leu Glu Asp Gly Ser Pro 
    130                 135                 140                 


Arg Thr Gly Gln Ile Phe Asn Gln Ser Tyr Ser Lys Phe Asp Thr Lys 
145                 150                 155                 160 


Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys 
                165                 170                 175     


Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Ile Val Gln 
            180                 185                 190         


Cys Arg Ser Val Glu Gly Ser Cys Gly Phe 
        195                 200         


<210>  5940
<211>  130
<212>  PRT
<213>  Homo Sapiens

<400>  5940

Met Leu Leu Trp Pro Leu Leu Leu Leu Leu Leu Leu Leu Pro Thr Leu 
1               5                   10                  15      


Ala Leu Leu Arg Gln Gln Arg Ser Gln Asp Ala Arg Leu Ser Trp Leu 
            20                  25                  30          


Ala Gly Leu Gln His Arg Val Ala Trp Gly Ala Leu Val Trp Ala Ala 
        35                  40                  45              


Thr Trp Gln Arg Arg Arg Leu Glu Gln Ser Thr Leu His Val His Gln 
    50                  55                  60                  


Ser Gln Gln Gln Ala Leu Arg Trp Cys Leu Gln Gly Ala Gln Arg Pro 
65                  70                  75                  80  


His Cys Ser Leu Arg Arg Ser Thr Asp Ile Ser Thr Phe Arg Asn His 
                85                  90                  95      


Leu Pro Leu Thr Lys Ala Ser Gln Thr Gln Gln Glu Asp Ser Gly Glu 
            100                 105                 110         


Gln Pro Leu Pro Pro Thr Ser Asn Gln Asp Leu Gly Glu Ala Ser Leu 
        115                 120                 125             


Gln Ala 
    130 


<210>  5941
<211>  146
<212>  PRT
<213>  Homo Sapiens

<400>  5941

Met Leu Leu Trp Pro Leu Leu Leu Leu Leu Leu Leu Leu Pro Thr Leu 
1               5                   10                  15      


Ala Leu Leu Arg Gln Gln Arg Ser Gln Asp Ala Arg Leu Ser Trp Leu 
            20                  25                  30          


Ala Gly Leu Gln His Arg Val Ala Trp Gly Ala Leu Val Trp Ala Ala 
        35                  40                  45              


Thr Trp Gln Arg Arg Arg Leu Glu Gln Ser Thr Leu His Val His Gln 
    50                  55                  60                  


Ser Gln Gln Gln Ala Leu Arg Trp Cys Leu Gln Gly Ala Gln Arg Pro 
65                  70                  75                  80  


His Cys Ser Leu Arg Arg Ser Thr Asp Ile Ser Thr Phe Arg Asn His 
                85                  90                  95      


Leu Pro Leu Thr Lys Ala Ser Gln Thr Gln Gln Glu Asp Ser Gly Glu 
            100                 105                 110         


Gln Pro Leu Pro Pro Thr Ser Asn Gln Asp Leu Gly Glu Ala Ser Leu 
        115                 120                 125             


Gln Ala Thr Leu Leu Gly Leu Ala Ala Leu Asn Lys Ala Tyr Pro Glu 
    130                 135                 140                 


Val Leu 
145     


<210>  5942
<211>  530
<212>  PRT
<213>  Homo Sapiens

<400>  5942

Met Leu Leu Trp Pro Leu Leu Leu Leu Leu Leu Leu Leu Pro Thr Leu 
1               5                   10                  15      


Ala Leu Leu Arg Gln Gln Arg Ser Gln Asp Ala Arg Leu Ser Trp Leu 
            20                  25                  30          


Ala Gly Leu Gln His Arg Val Ala Trp Gly Ala Leu Val Trp Ala Ala 
        35                  40                  45              


Thr Trp Gln Arg Arg Arg Leu Glu Gln Ser Thr Leu His Val His Gln 
    50                  55                  60                  


Ser Gln Gln Gln Ala Leu Arg Trp Cys Leu Gln Gly Ala Gln Arg Pro 
65                  70                  75                  80  


His Cys Ser Leu Arg Arg Ser Thr Asp Ile Ser Thr Phe Arg Asn His 
                85                  90                  95      


Leu Pro Leu Thr Lys Ala Ser Gln Thr Gln Gln Glu Asp Ser Gly Glu 
            100                 105                 110         


Gln Pro Leu Pro Pro Thr Ser Asn Gln Asp Leu Gly Glu Ala Ser Leu 
        115                 120                 125             


Gln Ala Thr Leu Leu Gly Leu Ala Ala Leu Asn Lys Ala Tyr Pro Glu 
    130                 135                 140                 


Val Leu Ala Gln Gly Arg Thr Ala Arg Val Thr Leu Thr Ser Pro Trp 
145                 150                 155                 160 


Pro Arg Pro Leu Pro Trp Pro Gly Asn Thr Leu Gly Gln Val Gly Thr 
                165                 170                 175     


Pro Gly Thr Lys Asp Pro Arg Ala Leu Leu Leu Asp Ala Leu Arg Ser 
            180                 185                 190         


Pro Gly Leu Arg Ala Leu Glu Ala Gly Thr Ala Val Glu Leu Leu Asp 
        195                 200                 205             


Val Phe Leu Gly Leu Glu Thr Asp Gly Glu Glu Leu Ala Gly Ala Ile 
    210                 215                 220                 


Ala Ala Gly Asn Pro Gly Ala Pro Leu Arg Glu Arg Ala Ala Glu Leu 
225                 230                 235                 240 


Arg Glu Ala Leu Glu Gln Gly Pro Arg Gly Leu Ala Leu Arg Leu Trp 
                245                 250                 255     


Pro Lys Leu Gln Val Val Val Thr Leu Asp Ala Gly Gly Gln Ala Glu 
            260                 265                 270         


Ala Val Ala Ala Leu Gly Ala Leu Trp Cys Gln Gly Leu Ala Phe Phe 
        275                 280                 285             


Ser Pro Ala Tyr Ala Ala Ser Gly Gly Val Leu Gly Leu Asn Leu Gln 
    290                 295                 300                 


Pro Glu Gln Pro His Gly Leu Tyr Leu Leu Pro Pro Gly Ala Pro Phe 
305                 310                 315                 320 


Ile Glu Leu Leu Pro Val Lys Glu Gly Thr Gln Glu Glu Ala Ala Ser 
                325                 330                 335     


Thr Leu Leu Leu Ala Glu Ala Gln Gln Gly Lys Glu Tyr Glu Leu Val 
            340                 345                 350         


Leu Thr Asp Arg Ala Ser Leu Thr Arg Cys Arg Leu Gly Asp Val Val 
        355                 360                 365             


Arg Val Val Gly Ala Tyr Asn Gln Cys Pro Val Val Arg Phe Ile Cys 
    370                 375                 380                 


Arg Leu Asp Gln Thr Leu Ser Val Arg Gly Glu Asp Ile Gly Glu Asp 
385                 390                 395                 400 


Leu Phe Ser Glu Ala Leu Gly Arg Ala Val Gly Gln Trp Ala Gly Ala 
                405                 410                 415     


Lys Leu Leu Asp His Gly Cys Val Glu Ser Ser Ile Leu Asp Ser Ser 
            420                 425                 430         


Ala Gly Ser Ala Pro His Tyr Glu Val Phe Val Ala Leu Arg Gly Leu 
        435                 440                 445             


Arg Asn Leu Ser Glu Glu Asn Arg Asp Lys Leu Asp His Cys Leu Gln 
    450                 455                 460                 


Glu Ala Ser Pro Arg Tyr Lys Ser Leu Arg Phe Trp Gly Ser Val Gly 
465                 470                 475                 480 


Pro Ala Arg Val His Leu Val Gly Gln Gly Ala Phe Arg Ala Leu Arg 
                485                 490                 495     


Ala Ala Leu Ala Ala Cys Pro Ser Ser Pro Phe Pro Pro Ala Met Pro 
            500                 505                 510         


Arg Val Leu Arg His Arg His Leu Ala Gln Cys Leu Gln Glu Arg Val 
        515                 520                 525             


Val Ser 
    530 


<210>  5943
<211>  474
<212>  PRT
<213>  Homo Sapiens

<400>  5943

Met Leu Leu Trp Pro Leu Leu Leu Leu Leu Leu Leu Leu Pro Thr Leu 
1               5                   10                  15      


Ala Leu Leu Arg Gln Gln Arg Ser Gln Asp Ala Arg Leu Ser Trp Leu 
            20                  25                  30          


Ala Gly Leu Gln His Arg Val Ala Trp Gly Ala Leu Val Trp Ala Ala 
        35                  40                  45              


Thr Trp Gln Arg Arg Arg Leu Glu Gln Ser Thr Leu His Val His Gln 
    50                  55                  60                  


Ser Gln Gln Gln Ala Leu Arg Trp Cys Leu Gln Gly Ala Gln Arg Pro 
65                  70                  75                  80  


His Cys Ser Leu Arg Arg Ser Thr Asp Ile Ser Thr Phe Arg Asn His 
                85                  90                  95      


Leu Pro Leu Thr Lys Ala Ser Gln Thr Gln Gln Glu Asp Ser Gly Glu 
            100                 105                 110         


Gln Pro Leu Pro Pro Thr Ser Asn Gln Asp Leu Gly Glu Ala Ser Leu 
        115                 120                 125             


Gln Ala Thr Leu Leu Gly Leu Ala Ala Leu Asn Lys Ala Tyr Pro Glu 
    130                 135                 140                 


Val Leu Ala Gln Gly Arg Thr Ala Arg Val Thr Leu Thr Ser Pro Trp 
145                 150                 155                 160 


Pro Arg Pro Leu Pro Trp Pro Gly Asn Thr Leu Gly Gln Val Gly Thr 
                165                 170                 175     


Pro Gly Thr Lys Asp Pro Arg Ala Leu Leu Leu Asp Ala Leu Arg Ser 
            180                 185                 190         


Pro Gly Leu Arg Ala Leu Glu Ala Gly Thr Ala Val Glu Leu Leu Asp 
        195                 200                 205             


Val Phe Leu Gly Leu Glu Thr Asp Gly Glu Glu Leu Ala Gly Ala Ile 
    210                 215                 220                 


Ala Ala Gly Asn Pro Gly Ala Pro Leu Arg Glu Arg Ala Ala Glu Leu 
225                 230                 235                 240 


Arg Glu Ala Leu Glu Gln Gly Pro Arg Gly Leu Ala Leu Arg Leu Trp 
                245                 250                 255     


Pro Lys Leu Gln Val Val Val Thr Leu Asp Ala Gly Gly Gln Ala Glu 
            260                 265                 270         


Ala Val Ala Ala Leu Gly Ala Leu Trp Cys Gln Gly Leu Ala Phe Phe 
        275                 280                 285             


Ser Pro Ala Tyr Ala Ala Ser Gly Gly Val Leu Gly Leu Asn Leu Gln 
    290                 295                 300                 


Pro Glu Gln Pro His Gly Leu Tyr Leu Leu Pro Pro Gly Ala Pro Phe 
305                 310                 315                 320 


Ile Glu Leu Leu Pro Val Lys Glu Gly Thr Gln Glu Glu Ala Ala Ser 
                325                 330                 335     


Thr Leu Leu Leu Ala Glu Ala Gln Gln Gly Lys Glu Tyr Glu Leu Val 
            340                 345                 350         


Leu Thr Asp Arg Ala Ser Leu Thr Arg Cys Arg Leu Gly Asp Val Val 
        355                 360                 365             


Arg Val Val Gly Ala Tyr Asn Gln Cys Pro Val Val Arg Phe Ile Cys 
    370                 375                 380                 


Arg Leu Asp Gln Thr Leu Ser Val Arg Gly Glu Asp Ile Gly Glu Asp 
385                 390                 395                 400 


Leu Phe Ser Glu Ala Leu Gly Arg Ala Val Gly Gln Trp Ala Gly Ala 
                405                 410                 415     


Lys Leu Leu Asp His Gly Cys Val Glu Ser Ser Ile Leu Glu Trp Gly 
            420                 425                 430         


Arg Thr Asp Arg Ala Glu Asp Thr Arg Leu Gly Ser Cys Pro Phe Thr 
        435                 440                 445             


Gly Ser Met Cys Ala His Gly Val Tyr Ser Gln Ile Pro Leu Arg Ala 
    450                 455                 460                 


Leu Leu Pro Thr Thr Arg Cys Leu Trp Arg 
465                 470                 


<210>  5944
<211>  474
<212>  PRT
<213>  Homo Sapiens

<400>  5944

Met Leu Leu Trp Pro Leu Leu Leu Leu Leu Leu Leu Leu Pro Thr Leu 
1               5                   10                  15      


Ala Leu Leu Arg Gln Gln Arg Ser Gln Asp Ala Arg Leu Ser Trp Leu 
            20                  25                  30          


Ala Gly Leu Gln His Arg Val Ala Trp Gly Ala Leu Val Trp Ala Ala 
        35                  40                  45              


Thr Trp Gln Arg Arg Arg Leu Glu Gln Ser Thr Leu His Val His Gln 
    50                  55                  60                  


Ser Gln Gln Gln Ala Leu Arg Trp Cys Leu Gln Gly Ala Gln Arg Pro 
65                  70                  75                  80  


His Cys Ser Leu Arg Arg Ser Thr Asp Ile Ser Thr Phe Arg Asn His 
                85                  90                  95      


Leu Pro Leu Thr Lys Ala Ser Gln Thr Gln Gln Glu Asp Ser Gly Glu 
            100                 105                 110         


Gln Pro Leu Pro Pro Thr Ser Asn Gln Asp Leu Gly Glu Ala Ser Leu 
        115                 120                 125             


Gln Ala Thr Leu Leu Gly Leu Ala Ala Leu Asn Lys Ala Tyr Pro Glu 
    130                 135                 140                 


Val Leu Ala Gln Gly Arg Thr Ala Arg Val Thr Leu Thr Ser Pro Trp 
145                 150                 155                 160 


Pro Arg Pro Leu Pro Trp Pro Gly Asn Thr Leu Gly Gln Val Gly Thr 
                165                 170                 175     


Pro Gly Thr Lys Asp Pro Arg Ala Leu Leu Leu Asp Ala Leu Arg Ser 
            180                 185                 190         


Pro Gly Leu Arg Ala Leu Glu Ala Gly Thr Ala Val Glu Leu Leu Asp 
        195                 200                 205             


Val Phe Leu Gly Leu Glu Thr Asp Gly Glu Glu Leu Ala Gly Ala Ile 
    210                 215                 220                 


Ala Ala Gly Asn Pro Gly Ala Pro Leu Arg Glu Arg Ala Ala Glu Leu 
225                 230                 235                 240 


Arg Glu Ala Leu Glu Gln Gly Pro Arg Gly Leu Ala Leu Arg Leu Trp 
                245                 250                 255     


Pro Lys Leu Gln Val Val Val Thr Leu Asp Ala Gly Gly Gln Ala Glu 
            260                 265                 270         


Ala Val Ala Ala Leu Gly Ala Leu Trp Cys Gln Gly Leu Ala Phe Phe 
        275                 280                 285             


Ser Pro Ala Tyr Ala Ala Ser Gly Gly Val Leu Gly Leu Asn Leu Gln 
    290                 295                 300                 


Pro Glu Gln Pro His Gly Leu Tyr Leu Leu Pro Pro Gly Ala Pro Phe 
305                 310                 315                 320 


Ile Glu Leu Leu Pro Val Lys Glu Gly Thr Gln Glu Glu Ala Ala Ser 
                325                 330                 335     


Thr Leu Leu Leu Ala Glu Ala Gln Gln Gly Lys Glu Tyr Glu Leu Val 
            340                 345                 350         


Leu Thr Asp Arg Ala Ser Leu Thr Arg Cys Arg Leu Gly Asp Val Val 
        355                 360                 365             


Arg Val Val Gly Ala Tyr Asn Gln Cys Pro Val Val Arg Phe Ile Cys 
    370                 375                 380                 


Arg Leu Asp Gln Thr Leu Ser Val Arg Gly Glu Asp Ile Gly Glu Asp 
385                 390                 395                 400 


Leu Phe Ser Glu Ala Leu Gly Arg Ala Val Gly Gln Trp Ala Gly Ala 
                405                 410                 415     


Lys Leu Leu Asp His Gly Cys Val Glu Ser Ser Ile Leu Glu Trp Gly 
            420                 425                 430         


Arg Thr Asp Arg Ala Glu Asp Thr Arg Leu Gly Ser Cys Pro Phe Thr 
        435                 440                 445             


Gly Ser Met Cys Ala His Gly Val Tyr Ser Gln Ile Pro Leu Arg Ala 
    450                 455                 460                 


Leu Leu Pro Thr Thr Arg Cys Leu Trp Arg 
465                 470                 


<210>  5945
<211>  530
<212>  PRT
<213>  Homo Sapiens

<400>  5945

Met Leu Leu Trp Pro Leu Leu Leu Leu Leu Leu Leu Leu Pro Thr Leu 
1               5                   10                  15      


Ala Leu Leu Arg Gln Gln Arg Ser Gln Asp Ala Arg Leu Ser Trp Leu 
            20                  25                  30          


Ala Gly Leu Gln His Arg Val Ala Trp Gly Ala Leu Val Trp Ala Ala 
        35                  40                  45              


Thr Trp Gln Arg Arg Arg Leu Glu Gln Ser Thr Leu His Val His Gln 
    50                  55                  60                  


Ser Gln Gln Gln Ala Leu Arg Trp Cys Leu Gln Gly Ala Gln Arg Pro 
65                  70                  75                  80  


His Cys Ser Leu Arg Arg Ser Thr Asp Ile Ser Thr Phe Arg Asn His 
                85                  90                  95      


Leu Pro Leu Thr Lys Ala Ser Gln Thr Gln Gln Glu Asp Ser Gly Glu 
            100                 105                 110         


Gln Pro Leu Pro Pro Thr Ser Asn Gln Asp Leu Gly Glu Ala Ser Leu 
        115                 120                 125             


Gln Ala Thr Leu Leu Gly Leu Ala Ala Leu Asn Lys Ala Tyr Pro Glu 
    130                 135                 140                 


Val Leu Ala Gln Gly Arg Thr Ala Arg Val Thr Leu Thr Ser Pro Trp 
145                 150                 155                 160 


Pro Arg Pro Leu Pro Trp Pro Gly Asn Thr Leu Gly Gln Val Gly Thr 
                165                 170                 175     


Pro Gly Thr Lys Asp Pro Arg Ala Leu Leu Leu Asp Ala Leu Arg Ser 
            180                 185                 190         


Pro Gly Leu Arg Ala Leu Glu Ala Gly Thr Ala Val Glu Leu Leu Asp 
        195                 200                 205             


Val Phe Leu Gly Leu Glu Thr Asp Gly Glu Glu Leu Ala Gly Ala Ile 
    210                 215                 220                 


Ala Ala Gly Asn Pro Gly Ala Pro Leu Arg Glu Arg Ala Ala Glu Leu 
225                 230                 235                 240 


Arg Glu Ala Leu Glu Gln Gly Pro Arg Gly Leu Ala Leu Arg Leu Trp 
                245                 250                 255     


Pro Lys Leu Gln Val Val Val Thr Leu Asp Ala Gly Gly Gln Ala Glu 
            260                 265                 270         


Ala Val Ala Ala Leu Gly Ala Leu Trp Cys Gln Gly Leu Ala Phe Phe 
        275                 280                 285             


Ser Pro Ala Tyr Ala Ala Ser Gly Gly Val Leu Gly Leu Asn Leu Gln 
    290                 295                 300                 


Pro Glu Gln Pro His Gly Leu Tyr Leu Leu Pro Pro Gly Ala Pro Phe 
305                 310                 315                 320 


Ile Glu Leu Leu Pro Val Lys Glu Gly Thr Gln Glu Glu Ala Ala Ser 
                325                 330                 335     


Thr Leu Leu Leu Ala Glu Ala Gln Gln Gly Lys Glu Tyr Glu Leu Val 
            340                 345                 350         


Leu Thr Asp Arg Ala Ser Leu Thr Arg Cys Arg Leu Gly Asp Val Val 
        355                 360                 365             


Arg Val Val Gly Ala Tyr Asn Gln Cys Pro Val Val Arg Phe Ile Cys 
    370                 375                 380                 


Arg Leu Asp Gln Thr Leu Ser Val Arg Gly Glu Asp Ile Gly Glu Asp 
385                 390                 395                 400 


Leu Phe Ser Glu Ala Leu Gly Arg Ala Val Gly Gln Trp Ala Gly Ala 
                405                 410                 415     


Lys Leu Leu Asp His Gly Cys Val Glu Ser Ser Ile Leu Asp Ser Ser 
            420                 425                 430         


Ala Gly Ser Ala Pro His Tyr Glu Val Phe Val Ala Leu Arg Gly Leu 
        435                 440                 445             


Arg Asn Leu Ser Glu Glu Asn Arg Asp Lys Leu Asp His Cys Leu Gln 
    450                 455                 460                 


Glu Ala Ser Pro Arg Tyr Lys Ser Leu Arg Phe Trp Gly Ser Val Gly 
465                 470                 475                 480 


Pro Ala Arg Val His Leu Val Gly Gln Gly Ala Phe Arg Ala Leu Arg 
                485                 490                 495     


Ala Ala Leu Ala Ala Cys Pro Ser Ser Pro Phe Pro Pro Ala Met Pro 
            500                 505                 510         


Arg Val Leu Arg His Arg His Leu Ala Gln Cys Leu Gln Glu Arg Val 
        515                 520                 525             


Val Ser 
    530 


<210>  5946
<211>  479
<212>  PRT
<213>  Homo Sapiens

<400>  5946

Met Leu Leu Trp Pro Leu Leu Leu Leu Leu Leu Leu Leu Pro Thr Leu 
1               5                   10                  15      


Ala Leu Leu Arg Gln Gln Arg Ser Gln Asp Ala Arg Leu Ser Trp Leu 
            20                  25                  30          


Ala Gly Leu Gln His Arg Val Ala Trp Gly Ala Leu Val Trp Ala Ala 
        35                  40                  45              


Thr Trp Gln Arg Arg Arg Leu Glu Gln Ser Thr Leu His Val His Gln 
    50                  55                  60                  


Ser Gln Gln Gln Ala Leu Arg Trp Cys Leu Gln Gly Ala Gln Arg Pro 
65                  70                  75                  80  


His Cys Ser Leu Arg Arg Ser Thr Asp Ile Ser Thr Phe Arg Asn His 
                85                  90                  95      


Leu Pro Leu Thr Lys Ala Ser Gln Thr Gln Gln Glu Asp Ser Gly Glu 
            100                 105                 110         


Gln Pro Leu Pro Pro Thr Ser Asn Gln Asp Leu Gly Glu Ala Ser Leu 
        115                 120                 125             


Gln Ala Thr Leu Leu Gly Leu Ala Ala Leu Asn Lys Ala Tyr Pro Glu 
    130                 135                 140                 


Val Leu Ala Gln Gly Arg Thr Ala Arg Val Thr Leu Thr Ser Pro Trp 
145                 150                 155                 160 


Pro Arg Pro Leu Pro Trp Pro Gly Asn Thr Leu Gly Gln Val Gly Thr 
                165                 170                 175     


Pro Gly Thr Lys Asp Pro Arg Ala Leu Leu Leu Asp Ala Leu Arg Ser 
            180                 185                 190         


Pro Gly Leu Arg Ala Leu Glu Ala Gly Thr Ala Val Glu Leu Leu Asp 
        195                 200                 205             


Val Phe Leu Gly Leu Glu Thr Asp Gly Glu Glu Leu Ala Gly Ala Ile 
    210                 215                 220                 


Ala Ala Gly Asn Pro Gly Ala Pro Leu Arg Glu Arg Ala Ala Glu Leu 
225                 230                 235                 240 


Arg Glu Ala Leu Glu Gln Gly Pro Arg Gly Leu Ala Leu Arg Leu Trp 
                245                 250                 255     


Pro Lys Leu Gln Val Val Val Thr Leu Asp Ala Gly Gly Gln Ala Glu 
            260                 265                 270         


Ala Val Ala Ala Leu Gly Ala Leu Trp Cys Gln Gly Leu Ala Phe Phe 
        275                 280                 285             


Ser Pro Ala Tyr Ala Ala Ser Gly Gly Val Leu Gly Leu Asn Leu Gln 
    290                 295                 300                 


Pro Glu Gln Pro His Gly Leu Tyr Leu Leu Pro Pro Gly Ala Pro Phe 
305                 310                 315                 320 


Ile Glu Leu Leu Pro Val Lys Glu Gly Thr Gln Glu Glu Ala Ala Ser 
                325                 330                 335     


Thr Leu Leu Leu Ala Glu Ala Gln Gln Gly Lys Glu Tyr Glu Leu Val 
            340                 345                 350         


Leu Thr Asp Arg Ala Ser Leu Thr Arg Cys Arg Leu Gly Asp Val Val 
        355                 360                 365             


Arg Val Val Gly Ala Tyr Asn Gln Cys Pro Val Val Arg Phe Ile Cys 
    370                 375                 380                 


Arg Leu Asp Gln Thr Leu Ser Val Arg Gly Glu Asp Ile Gly Glu Asp 
385                 390                 395                 400 


Leu Phe Ser Glu Ala Leu Gly Arg Ala Val Gly Gln Trp Ala Gly Ala 
                405                 410                 415     


Lys Leu Leu Asp His Gly Cys Val Glu Ser Ser Ile Leu Asp Ser Ser 
            420                 425                 430         


Ala Gly Ser Ala Pro His Tyr Glu Val Phe Val Ala Leu Arg Gly Leu 
        435                 440                 445             


Arg Asn Leu Ser Glu Glu Asn Arg Asp Lys Ile Leu Ala Ser Gly Ser 
    450                 455                 460                 


Ala Leu Gly Lys Arg Glu Trp Thr Pro Ala Gln Pro Phe Pro His 
465                 470                 475                 


<210>  5947
<211>  112
<212>  PRT
<213>  Homo Sapiens

<400>  5947

Met Leu Leu Trp Pro Leu Leu Leu Leu Leu Leu Leu Leu Pro Thr Leu 
1               5                   10                  15      


Ala Leu Leu Arg Gln Gln Arg Ser Gln Asp Ala Arg Leu Ser Trp Leu 
            20                  25                  30          


Ala Gly Leu Gln His Arg Val Ala Trp Gly Ala Leu Val Trp Ala Ala 
        35                  40                  45              


Thr Trp Gln Arg Arg Arg Leu Glu Gln Ser Thr Leu His Val His Gln 
    50                  55                  60                  


Ser Gln Gln Gln Ala Leu Arg Trp Cys Leu Gln Gly Ala Gln Arg Pro 
65                  70                  75                  80  


His Cys Ser Leu Arg Arg Ser Thr Gly Ser His Gln Ser Cys Leu Lys 
                85                  90                  95      


Leu Leu Gly Asn Trp Leu Pro Glu Ala Phe Leu Leu Ser Leu Gly Leu 
            100                 105                 110         


<210>  5948
<211>  107
<212>  PRT
<213>  Homo Sapiens

<400>  5948

Met Pro Leu Trp Val Phe Phe Phe Val Ile Leu Thr Leu Ser Asn Ser 
1               5                   10                  15      


Ser His Cys Ser Pro Pro Pro Pro Leu Thr Leu Arg Met Arg Arg Tyr 
            20                  25                  30          


Ala Asp Ala Ile Phe Thr Asn Ser Tyr Arg Lys Val Leu Gly Gln Leu 
        35                  40                  45              


Ser Ala Arg Lys Leu Leu Gln Asp Ile Met Ser Arg Gln Gln Gly Glu 
    50                  55                  60                  


Ser Asn Gln Glu Arg Gly Ala Arg Ala Arg Leu Gly Arg Gln Val Asp 
65                  70                  75                  80  


Ser Met Trp Ala Glu Gln Lys Gln Met Glu Leu Glu Ser Ile Leu Val 
                85                  90                  95      


Ala Leu Leu Gln Lys His Arg Asn Ser Gln Gly 
            100                 105         


<210>  5949
<211>  108
<212>  PRT
<213>  Homo Sapiens

<400>  5949

Met Pro Leu Trp Val Phe Phe Phe Val Ile Leu Thr Leu Ser Asn Ser 
1               5                   10                  15      


Ser His Cys Ser Pro Pro Pro Pro Leu Thr Leu Arg Met Arg Arg Tyr 
            20                  25                  30          


Ala Asp Ala Ile Phe Thr Asn Ser Tyr Arg Lys Val Leu Gly Gln Leu 
        35                  40                  45              


Ser Ala Arg Lys Leu Leu Gln Asp Ile Met Ser Arg Gln Gln Gly Glu 
    50                  55                  60                  


Ser Asn Gln Glu Arg Gly Ala Arg Ala Arg Leu Gly Arg Gln Val Asp 
65                  70                  75                  80  


Ser Met Trp Ala Glu Gln Lys Gln Met Glu Leu Glu Ser Ile Leu Val 
                85                  90                  95      


Ala Leu Leu Gln Lys His Ser Arg Asn Ser Gln Gly 
            100                 105             


<210>  5950
<211>  108
<212>  PRT
<213>  Homo Sapiens

<400>  5950

Met Pro Leu Trp Val Phe Phe Phe Val Ile Leu Thr Leu Ser Asn Ser 
1               5                   10                  15      


Ser His Cys Ser Pro Pro Pro Pro Leu Thr Leu Arg Met Arg Arg Tyr 
            20                  25                  30          


Ala Asp Ala Ile Phe Thr Asn Ser Tyr Arg Lys Val Leu Gly Gln Leu 
        35                  40                  45              


Ser Ala Arg Lys Leu Leu Gln Asp Ile Met Ser Arg Gln Gln Gly Glu 
    50                  55                  60                  


Ser Asn Gln Glu Arg Gly Ala Arg Ala Arg Leu Gly Arg Gln Val Asp 
65                  70                  75                  80  


Ser Met Trp Ala Glu Gln Lys Gln Met Glu Leu Glu Ser Ile Leu Val 
                85                  90                  95      


Ala Leu Leu Gln Lys His Ser Arg Asn Ser Gln Gly 
            100                 105             


<210>  5951
<211>  207
<212>  PRT
<213>  Homo Sapiens

<400>  5951

Met Ala Met Gly Glu Gly Ala Gly Gln Val Gly Glu Arg Gly Gly Ser 
1               5                   10                  15      


Met Gln Gly Leu Cys Gly Arg Leu Pro Phe Arg His His Asp Gln Leu 
            20                  25                  30          


Gln Leu Ala Val Gly Arg Ser Arg Leu Pro Glu Leu Pro Pro Gly Leu 
        35                  40                  45              


His Leu Pro Gln Leu Lys Glu Ser Leu Leu Val Ala Gly Ser Arg Trp 
    50                  55                  60                  


Leu Gly Ala Ala Arg Ala Leu His Trp His Val Gly Glu Leu Gln Thr 
65                  70                  75                  80  


Gly Leu Arg Gly His Arg Val Leu Gly Pro Gly Arg His Leu Pro Leu 
                85                  90                  95      


Leu Val Asp His Gln Arg Ala His Cys Pro Leu Gly Arg Gly Glu Leu 
            100                 105                 110         


Trp Ala Phe Ser Gln Tyr Tyr Pro His Pro Gly Glu Glu Thr Gly Ala 
        115                 120                 125             


Ser Ser Gly Gln Pro Pro Tyr Pro Val Ser Val Leu Ala Ser Leu Gln 
    130                 135                 140                 


Val Asp Thr Phe Pro Asp Pro Thr Leu Trp Asn Ser Leu His His Leu 
145                 150                 155                 160 


Gln Leu Pro Ala Arg Gln Cys Trp Pro Gly His Pro Pro Pro Pro Gly 
                165                 170                 175     


Ala Gly Thr Gly Phe Leu Pro Gly Ile Arg Arg Leu Gly Leu Arg Cys 
            180                 185                 190         


Arg Phe Leu Gly Arg Ser Phe Asp Cys Gln Pro Pro Arg Gly Ser 
        195                 200                 205         


<210>  5952
<211>  423
<212>  PRT
<213>  Homo Sapiens

<400>  5952

Met Asp Arg Arg Met Trp Gly Ala His Val Phe Cys Val Leu Ser Pro 
1               5                   10                  15      


Leu Pro Thr Val Leu Gly His Met His Pro Glu Cys Asp Phe Ile Thr 
            20                  25                  30          


Gln Leu Arg Glu Asp Glu Ser Ala Cys Leu Gln Ala Ala Glu Glu Met 
        35                  40                  45              


Pro Asn Thr Thr Leu Gly Cys Pro Ala Thr Trp Asp Gly Leu Leu Cys 
    50                  55                  60                  


Trp Pro Thr Ala Gly Ser Gly Glu Trp Val Thr Leu Pro Cys Pro Asp 
65                  70                  75                  80  


Phe Phe Ser His Phe Ser Ser Glu Ser Gly Ala Val Lys Arg Asp Cys 
                85                  90                  95      


Thr Ile Thr Gly Trp Ser Glu Pro Phe Pro Pro Tyr Pro Val Ala Cys 
            100                 105                 110         


Pro Val Pro Leu Glu Leu Leu Ala Glu Glu Glu Ser Tyr Phe Ser Thr 
        115                 120                 125             


Val Lys Ile Ile Tyr Thr Val Gly His Ser Ile Ser Ile Val Ala Leu 
    130                 135                 140                 


Phe Val Ala Ile Thr Ile Leu Val Ala Leu Arg Arg Leu His Cys Pro 
145                 150                 155                 160 


Arg Asn Tyr Val His Thr Gln Leu Phe Thr Thr Phe Ile Leu Lys Ala 
                165                 170                 175     


Gly Ala Val Phe Leu Lys Asp Ala Ala Leu Phe His Ser Asp Asp Thr 
            180                 185                 190         


Asp His Cys Ser Phe Ser Thr Val Leu Cys Lys Val Ser Val Ala Ala 
        195                 200                 205             


Ser His Phe Ala Thr Met Thr Asn Phe Ser Trp Leu Leu Ala Glu Ala 
    210                 215                 220                 


Val Tyr Leu Asn Cys Leu Leu Ala Ser Thr Ser Pro Ser Ser Arg Arg 
225                 230                 235                 240 


Ala Phe Trp Trp Leu Val Leu Ala Gly Trp Gly Leu Pro Val Leu Phe 
                245                 250                 255     


Thr Gly Thr Trp Val Ser Cys Lys Leu Ala Phe Glu Asp Ile Ala Cys 
            260                 265                 270         


Trp Asp Leu Asp Asp Thr Ser Pro Tyr Trp Trp Ile Ile Lys Gly Pro 
        275                 280                 285             


Ile Val Leu Ser Val Gly Val Asn Phe Gly Leu Phe Leu Asn Ile Ile 
    290                 295                 300                 


Arg Ile Leu Val Arg Lys Leu Glu Pro Ala Gln Gly Ser Leu His Thr 
305                 310                 315                 320 


Gln Ser Gln Tyr Trp Arg Leu Ser Lys Ser Thr Leu Phe Leu Ile Pro 
                325                 330                 335     


Leu Phe Gly Ile His Tyr Ile Ile Phe Asn Phe Leu Pro Asp Asn Ala 
            340                 345                 350         


Gly Leu Gly Ile Arg Leu Pro Leu Glu Leu Gly Leu Gly Ser Phe Gln 
        355                 360                 365             


Gly Phe Ile Val Ala Ile Leu Tyr Cys Phe Leu Asn Gln Glu Val Arg 
    370                 375                 380                 


Thr Glu Ile Ser Arg Lys Trp His Gly His Asp Pro Glu Leu Leu Pro 
385                 390                 395                 400 


Ala Trp Arg Thr Arg Ala Lys Trp Thr Thr Pro Ser Arg Ser Ala Ala 
                405                 410                 415     


Lys Val Leu Thr Ser Met Cys 
            420             


<210>  5953
<211>  151
<212>  PRT
<213>  Homo Sapiens

<400>  5953

Met Leu Pro Phe Ser Thr Ala Thr Thr Leu Thr Thr Ala Ala Ser Pro 
1               5                   10                  15      


Leu Ala Ala Arg Ala Leu His Trp His Val Gly Glu Leu Gln Thr Gly 
            20                  25                  30          


Leu Arg Gly His Arg Val Leu Gly Pro Gly Arg His Leu Pro Leu Leu 
        35                  40                  45              


Val Asp His Gln Arg Ala His Cys Pro Leu Gly Arg Gly Glu Leu Trp 
    50                  55                  60                  


Ala Phe Ser Gln Tyr Tyr Pro His Pro Gly Glu Glu Thr Gly Ala Ser 
65                  70                  75                  80  


Ser Gly Gln Pro Pro Tyr Pro Val Ser Val Leu Ala Ser Leu Gln Val 
                85                  90                  95      


Asp Thr Phe Pro Asp Pro Thr Leu Trp Asn Ser Leu His His Leu Gln 
            100                 105                 110         


Leu Pro Ala Arg Gln Cys Trp Pro Gly His Pro Pro Pro Pro Gly Ala 
        115                 120                 125             


Gly Thr Gly Phe Leu Pro Gly Leu His Cys Cys His Pro Leu Leu Leu 
    130                 135                 140                 


Pro Gln Pro Arg Gly Glu Asp 
145                 150     


<210>  5954
<211>  145
<212>  PRT
<213>  Homo Sapiens

<400>  5954

Met Val Pro Gly Thr Pro Ser Pro Leu Leu Gly Arg Gly Lys Glu Leu 
1               5                   10                  15      


Trp Leu Glu Ser Leu Ala Cys Leu Pro Gly Ala Val Lys Arg Asp Cys 
            20                  25                  30          


Thr Ile Thr Gly Trp Ser Glu Pro Phe Pro Pro Tyr Pro Val Ala Cys 
        35                  40                  45              


Pro Val Pro Leu Glu Leu Leu Ala Glu Glu Glu Ser Tyr Phe Ser Thr 
    50                  55                  60                  


Val Lys Ile Ile Tyr Thr Val Gly His Ser Ile Ser Ile Val Ala Leu 
65                  70                  75                  80  


Phe Val Ala Ile Thr Ile Leu Val Ala Leu Arg Arg Leu His Cys Pro 
                85                  90                  95      


Arg Asn Tyr Val His Thr Gln Leu Phe Thr Thr Phe Ile Leu Lys Ala 
            100                 105                 110         


Gly Ala Val Phe Leu Lys Asp Ala Ala Leu Phe His Ser Asp Asp Thr 
        115                 120                 125             


Asp His Cys Ser Phe Ser Thr Gly Cys Pro Cys Ser Ser Leu Ala Arg 
    130                 135                 140                 


Gly 
145 


<210>  5955
<211>  359
<212>  PRT
<213>  Homo Sapiens

<400>  5955

Met Val Pro Gly Thr Pro Ser Pro Leu Leu Gly Arg Gly Lys Glu Leu 
1               5                   10                  15      


Trp Leu Glu Ser Leu Ala Cys Leu Pro Gly Ala Val Lys Arg Asp Cys 
            20                  25                  30          


Thr Ile Thr Gly Trp Ser Glu Pro Phe Pro Pro Tyr Pro Val Ala Cys 
        35                  40                  45              


Pro Val Pro Leu Glu Leu Leu Ala Glu Glu Glu Ser Tyr Phe Ser Thr 
    50                  55                  60                  


Val Lys Ile Ile Tyr Thr Val Gly His Ser Ile Ser Ile Val Ala Leu 
65                  70                  75                  80  


Phe Val Ala Ile Thr Ile Leu Val Ala Leu Arg Arg Leu His Cys Pro 
                85                  90                  95      


Arg Asn Tyr Val His Thr Gln Leu Phe Thr Thr Phe Ile Leu Lys Ala 
            100                 105                 110         


Gly Ala Val Phe Leu Lys Asp Ala Ala Leu Phe His Ser Asp Asp Thr 
        115                 120                 125             


Asp His Cys Ser Phe Ser Thr Val Leu Cys Lys Val Ser Val Ala Ala 
    130                 135                 140                 


Ser His Phe Ala Thr Met Thr Asn Phe Ser Trp Leu Leu Ala Glu Ala 
145                 150                 155                 160 


Val Tyr Leu Asn Cys Leu Leu Ala Ser Thr Ser Pro Ser Ser Arg Arg 
                165                 170                 175     


Ala Phe Trp Trp Leu Val Leu Ala Gly Trp Gly Leu Pro Val Leu Phe 
            180                 185                 190         


Thr Gly Thr Trp Val Ser Cys Lys Leu Ala Phe Glu Asp Ile Ala Cys 
        195                 200                 205             


Trp Asp Leu Asp Asp Thr Ser Pro Tyr Trp Trp Ile Ile Lys Gly Pro 
    210                 215                 220                 


Ile Val Leu Ser Val Gly Val Asn Phe Gly Leu Phe Leu Asn Ile Ile 
225                 230                 235                 240 


Arg Ile Leu Val Arg Lys Leu Glu Pro Ala Gln Gly Ser Leu His Thr 
                245                 250                 255     


Gln Ser Gln Tyr Trp Arg Leu Ser Lys Ser Thr Leu Phe Leu Ile Pro 
            260                 265                 270         


Leu Phe Gly Ile His Tyr Ile Ile Phe Asn Phe Leu Pro Asp Asn Ala 
        275                 280                 285             


Gly Leu Gly Ile Arg Leu Pro Leu Glu Leu Gly Leu Gly Ser Phe Gln 
    290                 295                 300                 


Gly Phe Ile Val Ala Ile Leu Tyr Cys Phe Leu Asn Gln Glu Val Arg 
305                 310                 315                 320 


Thr Glu Ile Ser Arg Lys Trp His Gly His Asp Pro Glu Leu Leu Pro 
                325                 330                 335     


Ala Trp Arg Thr Arg Ala Lys Trp Thr Thr Pro Ser Arg Ser Ala Ala 
            340                 345                 350         


Lys Val Leu Thr Ser Met Cys 
        355                 


<210>  5956
<211>  68
<212>  PRT
<213>  Homo Sapiens

<400>  5956

Met Val Pro Gly Thr Pro Ser Pro Leu Leu Gly Arg Gly Lys Glu Leu 
1               5                   10                  15      


Trp Leu Glu Ser Leu Ala Cys Leu Pro Gly Ala Val Lys Arg Asp Cys 
            20                  25                  30          


Thr Ile Thr Gly Trp Ser Glu Pro Phe Pro Pro Tyr Pro Val Ala Cys 
        35                  40                  45              


Pro Val Pro Leu Glu Leu Leu Ala Glu Glu Gly Cys Pro Cys Ser Ser 
    50                  55                  60                  


Leu Ala Arg Gly 
65              


<210>  5957
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  5957

Met Phe Thr Cys Trp Trp Ser Tyr Leu Arg Ser Thr Leu Ala Ala Val 
1               5                   10                  15      


Pro Gly Glu Ala Ser Arg Val Gln Phe Asn Ala Pro Phe Asp Val Gly 
            20                  25                  30          


Ile Lys Leu Ser Gly Val Gln Tyr Gln Gln His Ser Gln Ala Leu Gly 
        35                  40                  45              


Lys Phe Leu Gln Asp Ile Leu Trp Glu Glu Ala Lys Glu Ala Pro Ala 
    50                  55                  60                  


Asp Lys 
65      


<210>  5958
<211>  105
<212>  PRT
<213>  Homo Sapiens

<400>  5958

Met Phe Thr Cys Trp Trp Ser Tyr Leu Arg Ser Thr Leu Ala Ala Val 
1               5                   10                  15      


Pro Gly Glu Ala Ser Arg Val Gln Gln Arg Lys Glu Ser Lys Lys Pro 
            20                  25                  30          


Pro Ala Lys Leu Gln Pro Arg Ala Leu Ala Gly Trp Leu Arg Pro Glu 
        35                  40                  45              


Asp Gly Gly Gln Ala Glu Gly Ala Glu Asp Glu Leu Glu Val Arg Phe 
    50                  55                  60                  


Asn Ala Pro Phe Asp Val Gly Ile Lys Leu Ser Gly Val Gln Tyr Gln 
65                  70                  75                  80  


Gln His Ser Gln Ala Leu Gly Lys Phe Leu Gln Asp Ile Leu Trp Glu 
                85                  90                  95      


Glu Ala Lys Glu Ala Pro Ala Asp Lys 
            100                 105 


<210>  5959
<211>  104
<212>  PRT
<213>  Homo Sapiens

<400>  5959

Met Phe Thr Cys Trp Trp Ser Tyr Leu Arg Ser Thr Leu Ala Ala Val 
1               5                   10                  15      


Pro Gly Glu Ala Ser Arg Val Gln Arg Lys Glu Ser Lys Lys Pro Pro 
            20                  25                  30          


Ala Lys Leu Gln Pro Arg Ala Leu Ala Gly Trp Leu Arg Pro Glu Asp 
        35                  40                  45              


Gly Gly Gln Ala Glu Gly Ala Glu Asp Glu Leu Glu Val Arg Phe Asn 
    50                  55                  60                  


Ala Pro Phe Asp Val Gly Ile Lys Leu Ser Gly Val Gln Tyr Gln Gln 
65                  70                  75                  80  


His Ser Gln Ala Leu Gly Lys Phe Leu Gln Asp Ile Leu Trp Glu Glu 
                85                  90                  95      


Ala Lys Glu Ala Pro Ala Asp Lys 
            100                 


<210>  5960
<211>  40
<212>  PRT
<213>  Homo Sapiens

<400>  5960

Met Phe Thr Cys Trp Trp Ser Tyr Leu Arg Ser Thr Leu Ala Ala Val 
1               5                   10                  15      


Pro Gly Glu Ala Ser Arg Val Gln Arg Pro Gln Pro Thr Ser Asp Arg 
            20                  25                  30          


Pro Gln Ala Leu Leu Thr Ser Leu 
        35                  40  


<210>  5961
<211>  33
<212>  PRT
<213>  Homo Sapiens

<400>  5961

Met Pro Ser Pro Gly Thr Val Cys Ser Leu Leu Leu Leu Gly Met Leu 
1               5                   10                  15      


Trp Leu Asp Leu Ala Met Ala Gly Ser Ser Phe Leu Ser Pro Glu His 
            20                  25                  30          


Gln 
    


<210>  5962
<211>  117
<212>  PRT
<213>  Homo Sapiens

<400>  5962

Met Pro Ser Pro Gly Thr Val Cys Ser Leu Leu Leu Leu Gly Met Leu 
1               5                   10                  15      


Trp Leu Asp Leu Ala Met Ala Gly Ser Ser Phe Leu Ser Pro Glu His 
            20                  25                  30          


Gln Arg Val Gln Gln Arg Lys Glu Ser Lys Lys Pro Pro Ala Lys Leu 
        35                  40                  45              


Gln Pro Arg Ala Leu Ala Gly Trp Leu Arg Pro Glu Asp Gly Gly Gln 
    50                  55                  60                  


Ala Glu Gly Ala Glu Asp Glu Leu Glu Val Arg Phe Asn Ala Pro Phe 
65                  70                  75                  80  


Asp Val Gly Ile Lys Leu Ser Gly Val Gln Tyr Gln Gln His Ser Gln 
                85                  90                  95      


Ala Leu Gly Lys Phe Leu Gln Asp Ile Leu Trp Glu Glu Ala Lys Glu 
            100                 105                 110         


Ala Pro Ala Asp Lys 
        115         


<210>  5963
<211>  117
<212>  PRT
<213>  Homo Sapiens

<400>  5963

Met Pro Ser Pro Gly Thr Val Cys Ser Leu Leu Leu Leu Gly Met Leu 
1               5                   10                  15      


Trp Leu Asp Leu Ala Met Ala Gly Ser Ser Phe Leu Ser Pro Glu His 
            20                  25                  30          


Gln Arg Val Gln Gln Arg Lys Glu Ser Lys Lys Pro Pro Ala Lys Leu 
        35                  40                  45              


Gln Pro Arg Ala Leu Ala Gly Trp Leu Arg Pro Glu Asp Gly Gly Gln 
    50                  55                  60                  


Ala Glu Gly Ala Glu Asp Glu Leu Glu Val Arg Phe Asn Ala Pro Phe 
65                  70                  75                  80  


Asp Val Gly Ile Lys Leu Ser Gly Val Gln Tyr Gln Gln His Ser Gln 
                85                  90                  95      


Ala Leu Gly Lys Phe Leu Gln Asp Ile Leu Trp Glu Glu Ala Lys Glu 
            100                 105                 110         


Ala Pro Ala Asp Lys 
        115         


<210>  5964
<211>  117
<212>  PRT
<213>  Homo Sapiens

<400>  5964

Met Pro Ser Pro Gly Thr Val Cys Ser Leu Leu Leu Leu Gly Met Leu 
1               5                   10                  15      


Trp Leu Asp Leu Ala Met Ala Gly Ser Ser Phe Leu Ser Pro Glu His 
            20                  25                  30          


Gln Arg Val Gln Gln Arg Lys Glu Ser Lys Lys Pro Pro Ala Lys Leu 
        35                  40                  45              


Gln Pro Arg Ala Leu Ala Gly Trp Leu Arg Pro Glu Asp Gly Gly Gln 
    50                  55                  60                  


Ala Glu Gly Ala Glu Asp Glu Leu Glu Val Arg Phe Asn Ala Pro Phe 
65                  70                  75                  80  


Asp Val Gly Ile Lys Leu Ser Gly Val Gln Tyr Gln Gln His Ser Gln 
                85                  90                  95      


Ala Leu Gly Lys Phe Leu Gln Asp Ile Leu Trp Glu Glu Ala Lys Glu 
            100                 105                 110         


Ala Pro Ala Asp Lys 
        115         


<210>  5965
<211>  91
<212>  PRT
<213>  Homo Sapiens

<400>  5965

Met Pro Ser Pro Gly Thr Val Cys Ser Leu Leu Leu Leu Gly Met Leu 
1               5                   10                  15      


Trp Leu Asp Leu Ala Met Ala Gly Ser Ser Phe Leu Ser Pro Glu His 
            20                  25                  30          


Gln Arg Val Gln Gln Arg Lys Glu Ser Lys Lys Pro Pro Ala Lys Leu 
        35                  40                  45              


Gln Pro Arg Ala Leu Ala Gly Trp Leu Arg Pro Glu Asp Gly Gly Gln 
    50                  55                  60                  


Ala Glu Gly Ala Glu Asp Glu Leu Glu Val Arg Arg Pro Gln Pro Thr 
65                  70                  75                  80  


Ser Asp Arg Pro Gln Ala Leu Leu Thr Ser Leu 
                85                  90      


<210>  5966
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  5966

Met Pro Ser Pro Gly Thr Val Cys Ser Leu Leu Leu Leu Gly Met Leu 
1               5                   10                  15      


Trp Leu Asp Leu Ala Met Ala Gly Ser Ser Phe Leu Ser Pro Glu His 
            20                  25                  30          


Gln Arg Val Gln Arg Lys Glu Ser Lys Lys Pro Pro Ala Lys Leu Gln 
        35                  40                  45              


Pro Arg Ala Leu Ala Gly Trp Leu Arg Pro Glu Asp Gly Gly Gln Ala 
    50                  55                  60                  


Glu Gly Ala Glu Asp Glu Leu Glu Val Arg Phe Asn Ala Pro Phe Asp 
65                  70                  75                  80  


Val Gly Ile Lys Leu Ser Gly Val Gln Tyr Gln Gln His Ser Gln Ala 
                85                  90                  95      


Leu Gly Lys Phe Leu Gln Asp Ile Leu Trp Glu Glu Ala Lys Glu Ala 
            100                 105                 110         


Pro Ala Asp Lys 
        115     


<210>  5967
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  5967

Met Pro Ser Pro Gly Thr Val Cys Ser Leu Leu Leu Leu Gly Met Leu 
1               5                   10                  15      


Trp Leu Asp Leu Ala Met Ala Gly Ser Ser Phe Leu Ser Pro Glu His 
            20                  25                  30          


Gln Arg Val Gln Arg Lys Glu Ser Lys Lys Pro Pro Ala Lys Leu Gln 
        35                  40                  45              


Pro Arg Ala Leu Ala Gly Trp Leu Arg Pro Glu Asp Gly Gly Gln Ala 
    50                  55                  60                  


Glu Gly Ala Glu Asp Glu Leu Glu Val Arg Phe Asn Ala Pro Phe Asp 
65                  70                  75                  80  


Val Gly Ile Lys Leu Ser Gly Val Gln Tyr Gln Gln His Ser Gln Ala 
                85                  90                  95      


Leu Gly Lys Phe Leu Gln Asp Ile Leu Trp Glu Glu Ala Lys Glu Ala 
            100                 105                 110         


Pro Ala Asp Lys 
        115     


<210>  5968
<211>  48
<212>  PRT
<213>  Homo Sapiens

<400>  5968

Met Ala Trp Phe Ala Leu Tyr Leu Leu Ser Leu Leu Trp Ala Thr Ala 
1               5                   10                  15      


Gly Thr Ser Thr Gln Thr Gln Ser Ser Cys Cys Glu Tyr Asp Val Phe 
            20                  25                  30          


Pro Arg Arg Ser Gly Lys Gln Leu Pro Trp Gly Arg Gly Cys Asp Leu 
        35                  40                  45              


<210>  5969
<211>  417
<212>  PRT
<213>  Homo Sapiens

<400>  5969

Met Ala Trp Phe Ala Leu Tyr Leu Leu Ser Leu Leu Trp Ala Thr Ala 
1               5                   10                  15      


Gly Thr Ser Thr Gln Thr Gln Ser Ser Cys Ser Val Pro Ser Ala Gln 
            20                  25                  30          


Glu Pro Leu Val Asn Gly Ile Gln Val Leu Met Glu Asn Ser Val Thr 
        35                  40                  45              


Ser Ser Ala Tyr Pro Asn Pro Ser Ile Leu Ile Ala Met Asn Leu Ala 
    50                  55                  60                  


Gly Ala Tyr Asn Leu Lys Ala Gln Lys Leu Leu Thr Tyr Gln Leu Met 
65                  70                  75                  80  


Ser Ser Asp Asn Asn Asp Leu Thr Ile Gly Gln Leu Gly Leu Thr Ile 
                85                  90                  95      


Met Ala Leu Thr Ser Ser Cys Arg Asp Pro Gly Asp Lys Val Ser Ile 
            100                 105                 110         


Leu Gln Arg Gln Met Glu Asn Trp Ala Pro Ser Ser Pro Asn Ala Glu 
        115                 120                 125             


Ala Ser Ala Phe Tyr Gly Pro Ser Leu Ala Ile Leu Ala Leu Cys Gln 
    130                 135                 140                 


Lys Asn Ser Glu Ala Thr Leu Pro Ile Ala Val Arg Phe Ala Lys Thr 
145                 150                 155                 160 


Leu Leu Ala Asn Ser Ser Pro Phe Asn Val Asp Thr Gly Ala Met Ala 
                165                 170                 175     


Thr Leu Ala Leu Thr Cys Met Tyr Asn Lys Ile Pro Val Gly Ser Glu 
            180                 185                 190         


Glu Gly Tyr Arg Ser Leu Phe Gly Gln Val Leu Lys Asp Ile Val Glu 
        195                 200                 205             


Lys Ile Ser Met Lys Ile Lys Asp Asn Gly Ile Ile Gly Asp Ile Tyr 
    210                 215                 220                 


Ser Thr Gly Leu Ala Met Gln Ala Leu Ser Val Thr Pro Glu Pro Ser 
225                 230                 235                 240 


Lys Lys Glu Trp Asn Cys Lys Lys Thr Thr Asp Met Ile Leu Asn Glu 
                245                 250                 255     


Ile Lys Gln Gly Lys Phe His Asn Pro Met Ser Ile Ala Gln Ile Leu 
            260                 265                 270         


Pro Ser Leu Lys Gly Lys Thr Tyr Leu Asp Val Pro Gln Val Thr Cys 
        275                 280                 285             


Ser Pro Asp His Glu Val Gln Pro Thr Leu Pro Ser Asn Pro Gly Pro 
    290                 295                 300                 


Gly Pro Thr Ser Ala Ser Asn Ile Thr Val Ile Tyr Thr Ile Asn Asn 
305                 310                 315                 320 


Gln Leu Arg Gly Val Glu Leu Leu Phe Asn Glu Thr Ile Asn Val Ser 
                325                 330                 335     


Val Lys Ser Gly Ser Val Leu Leu Val Val Leu Glu Glu Ala Gln Arg 
            340                 345                 350         


Lys Asn Pro Met Phe Lys Phe Glu Thr Thr Met Thr Ser Trp Gly Leu 
        355                 360                 365             


Val Val Ser Ser Ile Asn Asn Ile Ala Glu Asn Val Asn His Lys Thr 
    370                 375                 380                 


Tyr Trp Gln Phe Leu Ser Gly Val Thr Pro Leu Asn Glu Gly Val Ala 
385                 390                 395                 400 


Asp Tyr Ile Pro Phe Asn His Glu His Ile Thr Ala Asn Phe Thr Gln 
                405                 410                 415     


Tyr 
    


<210>  5970
<211>  153
<212>  PRT
<213>  Homo Sapiens

<400>  5970

Met Val Ala Thr Lys Thr Phe Ala Leu Leu Leu Leu Ser Leu Phe Leu 
1               5                   10                  15      


Ala Val Gly Leu Gly Glu Lys Lys Glu Gly His Phe Ser Ala Leu Pro 
            20                  25                  30          


Ser Leu Pro Val Gly Ser His Ala Lys Val Ser Ser Pro Gln Pro Arg 
        35                  40                  45              


Gly Pro Arg Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala 
    50                  55                  60                  


Met Asp Lys Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln 
65                  70                  75                  80  


Lys Gly Lys Lys Asn Asp Trp Lys His Asn Ile Thr Gln Arg Glu Ala 
                85                  90                  95      


Arg Ala Leu Glu Leu Ala Ser Gln Ala Asn Arg Lys Glu Glu Glu Ala 
            100                 105                 110         


Val Glu Pro Gln Ser Ser Pro Ala Lys Asn Pro Ser Asp Glu Asp Leu 
        115                 120                 125             


Leu Arg Asp Leu Leu Ile Gln Glu Leu Leu Ala Cys Leu Leu Asp Gln 
    130                 135                 140                 


Thr Asn Leu Cys Arg Leu Arg Ser Arg 
145                 150             


<210>  5971
<211>  199
<212>  PRT
<213>  Homo Sapiens

<400>  5971

Met Leu Ala Tyr Ser Ser Val His Cys Phe Arg Glu Asp Lys Met Lys 
1               5                   10                  15      


Phe Thr Ile Val Phe Ala Gly Leu Leu Gly Val Phe Leu Ala Pro Ala 
            20                  25                  30          


Leu Ala Asn Tyr Asn Ile Asn Val Asn Asp Asp Asn Asn Asn Ala Gly 
        35                  40                  45              


Ser Gly Gln Gln Ser Val Ser Val Asn Asn Glu His Asn Val Ala Asn 
    50                  55                  60                  


Val Asp Asn Asn Asn Gly Trp Asp Ser Trp Asn Ser Ile Trp Asp Tyr 
65                  70                  75                  80  


Gly Asn Gly Phe Ala Ala Thr Arg Leu Phe Gln Lys Lys Thr Cys Ile 
                85                  90                  95      


Val His Lys Met Asn Lys Glu Val Met Pro Ser Ile Gln Ser Leu Asp 
            100                 105                 110         


Ala Leu Val Lys Glu Lys Lys Leu Gln Gly Lys Gly Pro Gly Gly Pro 
        115                 120                 125             


Pro Pro Lys Gly Leu Met Tyr Ser Val Asn Pro Asn Lys Val Asp Asp 
    130                 135                 140                 


Leu Ser Lys Phe Gly Lys Asn Ile Ala Asn Met Cys Arg Gly Ile Pro 
145                 150                 155                 160 


Thr Tyr Met Ala Glu Glu Met Gln Glu Ala Ser Leu Phe Phe Tyr Ser 
                165                 170                 175     


Gly Thr Cys Tyr Thr Thr Ser Val Leu Trp Ile Val Asp Ile Ser Phe 
            180                 185                 190         


Cys Gly Asp Thr Val Glu Asn 
        195                 


<210>  5972
<211>  184
<212>  PRT
<213>  Homo Sapiens

<400>  5972

Met Lys Ile Leu Val Ala Phe Leu Val Val Leu Thr Ile Phe Gly Ile 
1               5                   10                  15      


Gln Ser His Gly Tyr Glu Val Phe Asn Ile Ile Ser Pro Ser Asn Asn 
            20                  25                  30          


Gly Gly Asn Val Gln Glu Thr Val Thr Ile Asp Asn Glu Lys Asn Thr 
        35                  40                  45              


Ala Ile Ile Asn Ile His Ala Gly Ser Cys Ser Ser Thr Thr Ile Phe 
    50                  55                  60                  


Asp Tyr Lys His Gly Tyr Ile Ala Ser Arg Val Leu Ser Arg Arg Ala 
65                  70                  75                  80  


Cys Phe Ile Leu Lys Met Asp His Gln Asn Ile Pro Pro Leu Asn Asn 
                85                  90                  95      


Leu Gln Trp Tyr Ile Tyr Glu Lys Gln Ala Leu Asp Asn Met Phe Ser 
            100                 105                 110         


Ser Lys Tyr Thr Trp Val Lys Tyr Asn Pro Leu Glu Ser Leu Ile Lys 
        115                 120                 125             


Asp Val Asp Trp Phe Leu Leu Gly Ser Pro Ile Glu Lys Leu Cys Lys 
    130                 135                 140                 


His Ile Pro Leu Tyr Lys Gly Glu Val Val Glu Asn Thr His Asn Val 
145                 150                 155                 160 


Gly Ala Gly Gly Cys Ala Lys Ala Gly Leu Leu Gly Ile Leu Gly Ile 
                165                 170                 175     


Ser Ile Cys Ala Asp Ile His Val 
            180                 


<210>  5973
<211>  161
<212>  PRT
<213>  Homo Sapiens

<400>  5973

Met Lys Ile Leu Val Ala Phe Leu Val Val Leu Thr Ile Phe Gly Ile 
1               5                   10                  15      


Gln Ser His Gly Tyr Glu Val Phe Asn Ile Ile Ser Pro Ser Asn Asn 
            20                  25                  30          


Gly Gly Asn Val Gln Glu Thr Val Thr Ile Asp Asn Glu Lys Asn Thr 
        35                  40                  45              


Ala Ile Ile Asn Ile His Ala Gly Ser Cys Ser Ser Thr Thr Ile Phe 
    50                  55                  60                  


Asp Tyr Lys His Gly Tyr Ile Ala Ser Arg Val Leu Ser Arg Arg Ala 
65                  70                  75                  80  


Cys Phe Ile Leu Lys Met Asp His Gln Asn Ile Pro Pro Leu Asn Asn 
                85                  90                  95      


Leu Gln Trp Tyr Ile Tyr Glu Lys Gln Ala Leu Asp Asn Met Phe Ser 
            100                 105                 110         


Ser Lys Tyr Thr Trp Val Lys Tyr Asn Pro Leu Glu Ser Leu Ile Lys 
        115                 120                 125             


Asp Val Asp Trp Phe Leu Leu Gly Ser Pro Ile Glu Lys Leu Cys Lys 
    130                 135                 140                 


His Ile Pro Leu Tyr Lys Gly Glu Val Val Glu Asn Thr Arg Glu Tyr 
145                 150                 155                 160 


Gln 
    


<210>  5974
<211>  429
<212>  PRT
<213>  Homo Sapiens

<400>  5974

Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Met Glu Met Ala Glu Leu Met Val Ser Glu Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn Tyr Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu Asn 
            180                 185                 190         


Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr Met 
        195                 200                 205             


Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys Asn 
    210                 215                 220                 


His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Lys Ser Ile Lys 
225                 230                 235                 240 


Ser Ile Leu Asp Trp Thr Ser Phe Asn Gln Glu Arg Ile Val Asp Val 
                245                 250                 255     


Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly Asn 
            260                 265                 270         


Phe Gly Leu Ser Trp Asn Gln Gln Val Thr Gln Met Ala Leu Trp Ala 
        275                 280                 285             


Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile Ser 
    290                 295                 300                 


Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile Asn 
305                 310                 315                 320 


Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Gln Gly Asp Asn 
                325                 330                 335     


Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Leu Ala Trp Ala Val Ala 
            340                 345                 350         


Met Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile Ala 
        355                 360                 365             


Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe Ile 
    370                 375                 380                 


Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Trp Thr 
385                 390                 395                 400 


Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu Gln 
                405                 410                 415     


Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
            420                 425                 


<210>  5975
<211>  222
<212>  PRT
<213>  Homo Sapiens

<400>  5975

Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Met Glu Met Ala Glu Leu Met Val Ser Glu Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn Tyr Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu Asn 
            180                 185                 190         


Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr Met 
        195                 200                 205             


Trp Pro Phe Gln Lys Ser Ser Thr Leu Phe Gly Ser Ile Cys 
    210                 215                 220         


<210>  5976
<211>  84
<212>  PRT
<213>  Homo Sapiens

<400>  5976

Met Phe Glu Ile Asp Tyr Ser Arg Asp Ser Phe Leu Lys Asp Gly Gln 
1               5                   10                  15      


Pro Phe Arg Tyr Ile Ser Gly Ser Ile His Tyr Ser Arg Val Pro Arg 
            20                  25                  30          


Phe Tyr Trp Lys Asp Arg Leu Leu Lys Met Lys Met Ala Gly Leu Asn 
        35                  40                  45              


Ala Ile Gln Thr Leu Pro Gly Ser Cys Gly Gln Val Val Gly Ser Pro 
    50                  55                  60                  


Ser Ala Gln Asp Glu Ala Ser Pro Leu Ser Glu Trp Arg Ala Ser Tyr 
65                  70                  75                  80  


Asn Ser Ala Gly 
                


<210>  5977
<211>  102
<212>  PRT
<213>  Homo Sapiens

<400>  5977

Met Phe Glu Ile Asp Tyr Ser Arg Asp Ser Phe Leu Lys Asp Gly Gln 
1               5                   10                  15      


Pro Phe Arg Tyr Ile Ser Gly Ser Ile His Tyr Ser Arg Val Pro Arg 
            20                  25                  30          


Phe Tyr Trp Lys Asp Arg Leu Leu Lys Met Lys Met Ala Gly Leu Asn 
        35                  40                  45              


Ala Ile Gln Thr Tyr Val Pro Trp Asn Phe His Glu Pro Trp Pro Gly 
    50                  55                  60                  


Gln Tyr Gln Phe Ser Glu Asp His Asp Val Glu Tyr Phe Leu Arg Leu 
65                  70                  75                  80  


Ala His Glu Leu Gly Leu Leu Val Ile Leu Arg Pro Gly Pro Tyr Ile 
                85                  90                  95      


Cys Ala Glu Trp Glu Met 
            100         


<210>  5978
<211>  647
<212>  PRT
<213>  Homo Sapiens

<400>  5978

Met Phe Glu Ile Asp Tyr Ser Arg Asp Ser Phe Leu Lys Asp Gly Gln 
1               5                   10                  15      


Pro Phe Arg Tyr Ile Ser Gly Ser Ile His Tyr Ser Arg Val Pro Arg 
            20                  25                  30          


Phe Tyr Trp Lys Asp Arg Leu Leu Lys Met Lys Met Ala Gly Leu Asn 
        35                  40                  45              


Ala Ile Gln Thr Tyr Val Pro Trp Asn Phe His Glu Pro Trp Pro Gly 
    50                  55                  60                  


Gln Tyr Gln Phe Ser Glu Asp His Asp Val Glu Tyr Phe Leu Arg Leu 
65                  70                  75                  80  


Ala His Glu Leu Gly Leu Leu Val Ile Leu Arg Pro Gly Pro Tyr Ile 
                85                  90                  95      


Cys Ala Glu Trp Glu Met Gly Gly Leu Pro Ala Trp Leu Leu Glu Lys 
            100                 105                 110         


Glu Ser Ile Leu Leu Arg Ser Ser Asp Pro Asp Tyr Leu Ala Ala Val 
        115                 120                 125             


Asp Lys Trp Leu Gly Val Leu Leu Pro Lys Met Lys Pro Leu Leu Tyr 
    130                 135                 140                 


Gln Asn Gly Gly Pro Val Ile Thr Val Gln Val Glu Asn Glu Tyr Gly 
145                 150                 155                 160 


Ser Tyr Phe Ala Cys Asp Phe Asp Tyr Leu Arg Phe Leu Gln Lys Arg 
                165                 170                 175     


Phe Arg His His Leu Gly Asp Asp Val Val Leu Phe Thr Thr Asp Gly 
            180                 185                 190         


Ala His Lys Thr Phe Leu Lys Cys Gly Ala Leu Gln Gly Leu Tyr Thr 
        195                 200                 205             


Thr Val Asp Phe Gly Thr Gly Ser Asn Ile Thr Asp Ala Phe Leu Ser 
    210                 215                 220                 


Gln Arg Lys Cys Glu Pro Lys Gly Pro Leu Ile Asn Ser Glu Phe Tyr 
225                 230                 235                 240 


Thr Gly Trp Leu Asp His Trp Gly Gln Pro His Ser Thr Ile Lys Thr 
                245                 250                 255     


Glu Ala Val Ala Ser Ser Leu Tyr Asp Ile Leu Ala Arg Gly Ala Ser 
            260                 265                 270         


Val Asn Leu Tyr Met Phe Ile Gly Gly Thr Asn Phe Ala Tyr Trp Asn 
        275                 280                 285             


Gly Ala Asn Ser Pro Tyr Ala Ala Gln Pro Thr Ser Tyr Asp Tyr Asp 
    290                 295                 300                 


Ala Pro Leu Ser Glu Ala Gly Asp Leu Thr Glu Lys Tyr Phe Ala Leu 
305                 310                 315                 320 


Arg Asn Ile Ile Gln Lys Phe Glu Lys Val Pro Glu Gly Pro Ile Pro 
                325                 330                 335     


Pro Ser Thr Pro Lys Phe Ala Tyr Gly Lys Val Thr Leu Glu Lys Leu 
            340                 345                 350         


Lys Thr Val Gly Ala Ala Leu Asp Ile Leu Cys Pro Ser Gly Pro Ile 
        355                 360                 365             


Lys Ser Leu Tyr Pro Leu Thr Phe Ile Gln Val Lys Gln His Tyr Gly 
    370                 375                 380                 


Phe Val Leu Tyr Arg Thr Thr Leu Pro Gln Asp Cys Ser Asn Pro Ala 
385                 390                 395                 400 


Pro Leu Ser Ser Pro Leu Asn Gly Val His Asp Arg Ala Tyr Val Ala 
                405                 410                 415     


Val Asp Gly Ile Pro Gln Gly Val Leu Glu Arg Asn Asn Val Ile Thr 
            420                 425                 430         


Leu Asn Ile Thr Gly Lys Ala Gly Ala Thr Leu Asp Leu Leu Val Glu 
        435                 440                 445             


Asn Met Gly Arg Val Asn Tyr Gly Ala Tyr Ile Asn Asp Phe Lys Gly 
    450                 455                 460                 


Leu Val Ser Asn Leu Thr Leu Ser Ser Asn Ile Leu Thr Asp Trp Thr 
465                 470                 475                 480 


Ile Phe Pro Leu Asp Thr Glu Asp Ala Val Cys Ser His Leu Gly Gly 
                485                 490                 495     


Trp Gly His Arg Asp Ser Gly His His Asp Glu Ala Trp Ala His Asn 
            500                 505                 510         


Ser Ser Asn Tyr Thr Leu Pro Ala Phe Tyr Met Gly Asn Phe Ser Ile 
        515                 520                 525             


Pro Ser Gly Ile Pro Asp Leu Pro Gln Asp Thr Phe Ile Gln Phe Pro 
    530                 535                 540                 


Gly Trp Thr Lys Gly Gln Val Trp Ile Asn Gly Phe Asn Leu Gly Arg 
545                 550                 555                 560 


Tyr Trp Pro Ala Arg Gly Pro Gln Leu Thr Leu Phe Val Pro Gln His 
                565                 570                 575     


Ile Leu Met Thr Ser Ala Pro Asn Thr Ile Thr Val Leu Glu Leu Glu 
            580                 585                 590         


Trp Ala Pro Cys Ser Ser Asp Asp Pro Glu Leu Cys Ala Val Thr Phe 
        595                 600                 605             


Val Asp Arg Pro Val Ile Gly Ser Ser Val Thr Tyr Asp His Pro Ser 
    610                 615                 620                 


Lys Pro Val Glu Lys Arg Leu Met Pro Pro Pro Pro Gln Lys Asn Lys 
625                 630                 635                 640 


Asp Ser Trp Leu Asp His Val 
                645         


<210>  5979
<211>  114
<212>  PRT
<213>  Homo Sapiens

<400>  5979

Met Gly Gly Leu Pro Ala Trp Leu Leu Glu Lys Glu Ser Ile Leu Leu 
1               5                   10                  15      


Arg Ser Ser Asp Pro Asp Tyr Leu Ala Ala Val Asp Lys Trp Leu Gly 
            20                  25                  30          


Val Leu Leu Pro Lys Met Lys Pro Leu Leu Tyr Gln Asn Gly Gly Pro 
        35                  40                  45              


Val Ile Thr Val Gln Val Glu Asn Glu Tyr Gly Ser Tyr Phe Ala Cys 
    50                  55                  60                  


Asp Phe Asp Tyr Leu Arg Phe Leu Gln Lys Arg Phe Arg His His Leu 
65                  70                  75                  80  


Gly Asp Asp Val Val Leu Phe Thr Thr Asp Gly Ala His Lys Thr Phe 
                85                  90                  95      


Leu Lys Cys Gly Ala Leu Gln Gly Leu Tyr Thr Thr Val Asp Phe Gly 
            100                 105                 110         


Thr Gly 
        


<210>  5980
<211>  41
<212>  PRT
<213>  Homo Sapiens

<400>  5980

Met Pro Gly Phe Leu Val Arg Ile Leu Pro Leu Leu Leu Val Leu Leu 
1               5                   10                  15      


Leu Leu Gly Pro Thr Arg Gly Leu Arg Ile Thr Trp Gln Leu Trp Thr 
            20                  25                  30          


Ser Gly Trp Glu Ser Phe Cys Pro Arg 
        35                  40      


<210>  5981
<211>  546
<212>  PRT
<213>  Homo Sapiens

<400>  5981

Met Pro Gly Phe Leu Val Arg Ile Leu Pro Leu Leu Leu Val Leu Leu 
1               5                   10                  15      


Leu Leu Gly Pro Thr Arg Gly Leu Arg Asn Ala Thr Gln Arg Met Phe 
            20                  25                  30          


Glu Ile Asp Tyr Ser Arg Asp Ser Phe Leu Lys Asp Gly Gln Pro Phe 
        35                  40                  45              


Arg Tyr Ile Ser Gly Ser Ile His Tyr Ser Arg Val Pro Arg Phe Tyr 
    50                  55                  60                  


Trp Lys Asp Arg Leu Leu Lys Met Lys Met Ala Gly Leu Asn Ala Ile 
65                  70                  75                  80  


Gln Thr Leu Pro Gly Ser Cys Gly Gln Val Val Gly Ser Pro Ser Ala 
                85                  90                  95      


Gln Asp Glu Ala Ser Pro Leu Ser Glu Trp Arg Ala Ser Tyr Asn Ser 
            100                 105                 110         


Ala Gly Ser Asn Ile Thr Asp Ala Phe Leu Ser Gln Arg Lys Cys Glu 
        115                 120                 125             


Pro Lys Gly Pro Leu Ile Asn Ser Glu Phe Tyr Thr Gly Trp Leu Asp 
    130                 135                 140                 


His Trp Gly Gln Pro His Ser Thr Ile Lys Thr Glu Ala Val Ala Ser 
145                 150                 155                 160 


Ser Leu Tyr Asp Ile Leu Ala Arg Gly Ala Ser Val Asn Leu Tyr Met 
                165                 170                 175     


Phe Ile Gly Gly Thr Asn Phe Ala Tyr Trp Asn Gly Ala Asn Ser Pro 
            180                 185                 190         


Tyr Ala Ala Gln Pro Thr Ser Tyr Asp Tyr Asp Ala Pro Leu Ser Glu 
        195                 200                 205             


Ala Gly Asp Leu Thr Glu Lys Tyr Phe Ala Leu Arg Asn Ile Ile Gln 
    210                 215                 220                 


Lys Phe Glu Lys Val Pro Glu Gly Pro Ile Pro Pro Ser Thr Pro Lys 
225                 230                 235                 240 


Phe Ala Tyr Gly Lys Val Thr Leu Glu Lys Leu Lys Thr Val Gly Ala 
                245                 250                 255     


Ala Leu Asp Ile Leu Cys Pro Ser Gly Pro Ile Lys Ser Leu Tyr Pro 
            260                 265                 270         


Leu Thr Phe Ile Gln Val Lys Gln His Tyr Gly Phe Val Leu Tyr Arg 
        275                 280                 285             


Thr Thr Leu Pro Gln Asp Cys Ser Asn Pro Ala Pro Leu Ser Ser Pro 
    290                 295                 300                 


Leu Asn Gly Val His Asp Arg Ala Tyr Val Ala Val Asp Gly Ile Pro 
305                 310                 315                 320 


Gln Gly Val Leu Glu Arg Asn Asn Val Ile Thr Leu Asn Ile Thr Gly 
                325                 330                 335     


Lys Ala Gly Ala Thr Leu Asp Leu Leu Val Glu Asn Met Gly Arg Val 
            340                 345                 350         


Asn Tyr Gly Ala Tyr Ile Asn Asp Phe Lys Gly Leu Val Ser Asn Leu 
        355                 360                 365             


Thr Leu Ser Ser Asn Ile Leu Thr Asp Trp Thr Ile Phe Pro Leu Asp 
    370                 375                 380                 


Thr Glu Asp Ala Val Cys Ser His Leu Gly Gly Trp Gly His Arg Asp 
385                 390                 395                 400 


Ser Gly His His Asp Glu Ala Trp Ala His Asn Ser Ser Asn Tyr Thr 
                405                 410                 415     


Leu Pro Ala Phe Tyr Met Gly Asn Phe Ser Ile Pro Ser Gly Ile Pro 
            420                 425                 430         


Asp Leu Pro Gln Asp Thr Phe Ile Gln Phe Pro Gly Trp Thr Lys Gly 
        435                 440                 445             


Gln Val Trp Ile Asn Gly Phe Asn Leu Gly Arg Tyr Trp Pro Ala Arg 
    450                 455                 460                 


Gly Pro Gln Leu Thr Leu Phe Val Pro Gln His Ile Leu Met Thr Ser 
465                 470                 475                 480 


Ala Pro Asn Thr Ile Thr Val Leu Glu Leu Glu Trp Ala Pro Cys Ser 
                485                 490                 495     


Ser Asp Asp Pro Glu Leu Cys Ala Val Thr Phe Val Asp Arg Pro Val 
            500                 505                 510         


Ile Gly Ser Ser Val Thr Tyr Asp His Pro Ser Lys Pro Val Glu Lys 
        515                 520                 525             


Arg Leu Met Pro Pro Pro Pro Gln Lys Asn Lys Asp Ser Trp Leu Asp 
    530                 535                 540                 


His Val 
545     


<210>  5982
<211>  677
<212>  PRT
<213>  Homo Sapiens

<400>  5982

Met Pro Gly Phe Leu Val Arg Ile Leu Pro Leu Leu Leu Val Leu Leu 
1               5                   10                  15      


Leu Leu Gly Pro Thr Arg Gly Leu Arg Asn Ala Thr Gln Arg Met Phe 
            20                  25                  30          


Glu Ile Asp Tyr Ser Arg Asp Ser Phe Leu Lys Asp Gly Gln Pro Phe 
        35                  40                  45              


Arg Tyr Ile Ser Gly Ser Ile His Tyr Ser Arg Val Pro Arg Phe Tyr 
    50                  55                  60                  


Trp Lys Asp Arg Leu Leu Lys Met Lys Met Ala Gly Leu Asn Ala Ile 
65                  70                  75                  80  


Gln Thr Tyr Val Pro Trp Asn Phe His Glu Pro Trp Pro Gly Gln Tyr 
                85                  90                  95      


Gln Phe Ser Glu Asp His Asp Val Glu Tyr Phe Leu Arg Leu Ala His 
            100                 105                 110         


Glu Leu Gly Leu Leu Val Ile Leu Arg Pro Gly Pro Tyr Ile Cys Ala 
        115                 120                 125             


Glu Trp Glu Met Gly Gly Leu Pro Ala Trp Leu Leu Glu Lys Glu Ser 
    130                 135                 140                 


Ile Leu Leu Arg Ser Ser Asp Pro Asp Tyr Leu Ala Ala Val Asp Lys 
145                 150                 155                 160 


Trp Leu Gly Val Leu Leu Pro Lys Met Lys Pro Leu Leu Tyr Gln Asn 
                165                 170                 175     


Gly Gly Pro Val Ile Thr Val Gln Val Glu Asn Glu Tyr Gly Ser Tyr 
            180                 185                 190         


Phe Ala Cys Asp Phe Asp Tyr Leu Arg Phe Leu Gln Lys Arg Phe Arg 
        195                 200                 205             


His His Leu Gly Asp Asp Val Val Leu Phe Thr Thr Asp Gly Ala His 
    210                 215                 220                 


Lys Thr Phe Leu Lys Cys Gly Ala Leu Gln Gly Leu Tyr Thr Thr Val 
225                 230                 235                 240 


Asp Phe Gly Thr Gly Ser Asn Ile Thr Asp Ala Phe Leu Ser Gln Arg 
                245                 250                 255     


Lys Cys Glu Pro Lys Gly Pro Leu Ile Asn Ser Glu Phe Tyr Thr Gly 
            260                 265                 270         


Trp Leu Asp His Trp Gly Gln Pro His Ser Thr Ile Lys Thr Glu Ala 
        275                 280                 285             


Val Ala Ser Ser Leu Tyr Asp Ile Leu Ala Arg Gly Ala Ser Val Asn 
    290                 295                 300                 


Leu Tyr Met Phe Ile Gly Gly Thr Asn Phe Ala Tyr Trp Asn Gly Ala 
305                 310                 315                 320 


Asn Ser Pro Tyr Ala Ala Gln Pro Thr Ser Tyr Asp Tyr Asp Ala Pro 
                325                 330                 335     


Leu Ser Glu Ala Gly Asp Leu Thr Glu Lys Tyr Phe Ala Leu Arg Asn 
            340                 345                 350         


Ile Ile Gln Lys Phe Glu Lys Val Pro Glu Gly Pro Ile Pro Pro Ser 
        355                 360                 365             


Thr Pro Lys Phe Ala Tyr Gly Lys Val Thr Leu Glu Lys Leu Lys Thr 
    370                 375                 380                 


Val Gly Ala Ala Leu Asp Ile Leu Cys Pro Ser Gly Pro Ile Lys Ser 
385                 390                 395                 400 


Leu Tyr Pro Leu Thr Phe Ile Gln Val Lys Gln His Tyr Gly Phe Val 
                405                 410                 415     


Leu Tyr Arg Thr Thr Leu Pro Gln Asp Cys Ser Asn Pro Ala Pro Leu 
            420                 425                 430         


Ser Ser Pro Leu Asn Gly Val His Asp Arg Ala Tyr Val Ala Val Asp 
        435                 440                 445             


Gly Ile Pro Gln Gly Val Leu Glu Arg Asn Asn Val Ile Thr Leu Asn 
    450                 455                 460                 


Ile Thr Gly Lys Ala Gly Ala Thr Leu Asp Leu Leu Val Glu Asn Met 
465                 470                 475                 480 


Gly Arg Val Asn Tyr Gly Ala Tyr Ile Asn Asp Phe Lys Gly Leu Val 
                485                 490                 495     


Ser Asn Leu Thr Leu Ser Ser Asn Ile Leu Thr Asp Trp Thr Ile Phe 
            500                 505                 510         


Pro Leu Asp Thr Glu Asp Ala Val Cys Ser His Leu Gly Gly Trp Gly 
        515                 520                 525             


His Arg Asp Ser Gly His His Asp Glu Ala Trp Ala His Asn Ser Ser 
    530                 535                 540                 


Asn Tyr Thr Leu Pro Ala Phe Tyr Met Gly Asn Phe Ser Ile Pro Ser 
545                 550                 555                 560 


Gly Ile Pro Asp Leu Pro Gln Asp Thr Phe Ile Gln Phe Pro Gly Trp 
                565                 570                 575     


Thr Lys Gly Gln Val Trp Ile Asn Gly Phe Asn Leu Gly Arg Tyr Trp 
            580                 585                 590         


Pro Ala Arg Gly Pro Gln Leu Thr Leu Phe Val Pro Gln His Ile Leu 
        595                 600                 605             


Met Thr Ser Ala Pro Asn Thr Ile Thr Val Leu Glu Leu Glu Trp Ala 
    610                 615                 620                 


Pro Cys Ser Ser Asp Asp Pro Glu Leu Cys Ala Val Thr Phe Val Asp 
625                 630                 635                 640 


Arg Pro Val Ile Gly Ser Ser Val Thr Tyr Asp His Pro Ser Lys Pro 
                645                 650                 655     


Val Glu Lys Arg Leu Met Pro Pro Pro Pro Gln Lys Asn Lys Asp Ser 
            660                 665                 670         


Trp Leu Asp His Val 
        675         


<210>  5983
<211>  147
<212>  PRT
<213>  Homo Sapiens

<400>  5983

Met Pro Gly Phe Leu Val Arg Ile Leu Pro Leu Leu Leu Val Leu Leu 
1               5                   10                  15      


Leu Leu Gly Pro Thr Arg Gly Leu Arg Ser Arg Phe Leu Pro Trp Ala 
            20                  25                  30          


Phe His Leu Pro Arg Gln Ala Pro Lys Ser Gln Leu Pro Leu His Lys 
        35                  40                  45              


Arg Gly Thr Lys Thr Ala Pro Asn Glu His Ala Ser Ser Asn Arg Ser 
    50                  55                  60                  


Gly Arg Arg Arg Arg Arg Gln Gln Trp Asn Ala Thr Gln Arg Met Phe 
65                  70                  75                  80  


Glu Ile Asp Tyr Ser Arg Asp Ser Phe Leu Lys Asp Gly Gln Pro Phe 
                85                  90                  95      


Arg Tyr Ile Ser Gly Ser Ile His Tyr Ser Arg Val Pro Arg Phe Tyr 
            100                 105                 110         


Trp Lys Asp Arg Leu Leu Lys Met Lys Met Ala Gly Leu Asn Ala Ile 
        115                 120                 125             


Gln Thr Tyr Val Pro Trp Asn Phe His Glu Pro Trp Pro Gly Gln Tyr 
    130                 135                 140                 


Gln Phe Ser 
145         


<210>  5984
<211>  185
<212>  PRT
<213>  Homo Sapiens

<400>  5984

Met Pro Gly Phe Leu Val Arg Ile Leu Pro Leu Leu Leu Val Leu Leu 
1               5                   10                  15      


Leu Leu Gly Pro Thr Arg Gly Leu Arg Val Glu Asn Glu Tyr Gly Ser 
            20                  25                  30          


Tyr Phe Ala Cys Asp Phe Asp Tyr Leu Arg Phe Leu Gln Lys Arg Phe 
        35                  40                  45              


Arg His His Leu Gly Asp Asp Val Val Leu Phe Thr Thr Asp Gly Ala 
    50                  55                  60                  


His Lys Thr Phe Leu Lys Cys Gly Ala Leu Gln Gly Leu Tyr Thr Thr 
65                  70                  75                  80  


Val Asp Phe Gly Thr Gly Ser Asn Ile Thr Asp Ala Phe Leu Ser Gln 
                85                  90                  95      


Arg Lys Cys Glu Pro Lys Gly Pro Leu Ile Asn Ser Glu Phe Tyr Thr 
            100                 105                 110         


Gly Trp Leu Asp His Trp Gly Gln Pro His Ser Thr Ile Lys Thr Glu 
        115                 120                 125             


Ala Val Ala Ser Ser Leu Tyr Asp Ile Leu Ala Arg Gly Ala Ser Val 
    130                 135                 140                 


Asn Leu Tyr Met Phe Ile Gly Gly Thr Asn Phe Ala Tyr Trp Asn Gly 
145                 150                 155                 160 


Ala Asn Ser Pro Tyr Ala Ala Gln Pro Thr Ser Tyr Asp Tyr Asp Ala 
                165                 170                 175     


Pro Leu Ser Glu Ala Gly Asp Leu Thr 
            180                 185 


<210>  5985
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  5985

Met Ala Pro Lys Lys Leu Ser Cys Leu 
1               5                   


<210>  5986
<211>  26
<212>  PRT
<213>  Homo Sapiens

<400>  5986

Met Ala Pro Lys Lys Leu Ser Cys Leu Arg Ser Leu Leu Leu Pro Leu 
1               5                   10                  15      


Ser Leu Thr Leu Leu Leu Pro Gln Ala Asp 
            20                  25      


<210>  5987
<211>  114
<212>  PRT
<213>  Homo Sapiens

<400>  5987

Met Ala Pro Lys Lys Leu Ser Cys Leu Arg Ser Leu Leu Leu Pro Leu 
1               5                   10                  15      


Ser Leu Thr Leu Leu Leu Pro Gln Ala Asp Thr Arg Ser Phe Val Val 
            20                  25                  30          


Asp Arg Gly His Asp Arg Phe Leu Leu Asp Gly Ala Pro Phe Arg Tyr 
        35                  40                  45              


Val Ser Gly Ser Leu His Tyr Phe Arg Val Pro Arg Val Leu Trp Ala 
    50                  55                  60                  


Asp Arg Leu Leu Lys Met Arg Trp Ser Gly Leu Asn Ala Ile Gln Phe 
65                  70                  75                  80  


Tyr Val Pro Trp Asn Tyr His Glu Pro Gln Pro Gly Val Tyr Asn Phe 
                85                  90                  95      


Asn Gly Ser Arg Asp Leu Ile Ala Phe Leu Asn Glu Ala Ala Leu Ala 
            100                 105                 110         


Asn Leu 
        


<210>  5988
<211>  564
<212>  PRT
<213>  Homo Sapiens

<400>  5988

Met Ala Pro Lys Lys Leu Ser Cys Leu Arg Ser Leu Leu Leu Pro Leu 
1               5                   10                  15      


Ser Leu Thr Leu Leu Leu Pro Gln Ala Asp Thr Arg Ser Phe Val Val 
            20                  25                  30          


Asp Arg Gly His Asp Arg Phe Leu Leu Asp Gly Ala Pro Phe Arg Tyr 
        35                  40                  45              


Val Ser Gly Ser Leu His Tyr Phe Arg Val Pro Arg Val Leu Trp Ala 
    50                  55                  60                  


Asp Arg Leu Leu Lys Met Arg Trp Ser Gly Leu Asn Ala Ile Gln Phe 
65                  70                  75                  80  


Tyr Val Pro Trp Asn Tyr His Glu Pro Gln Pro Gly Val Tyr Asn Phe 
                85                  90                  95      


Asn Gly Ser Arg Asp Leu Ile Ala Phe Leu Asn Glu Ala Ala Leu Ala 
            100                 105                 110         


Asn Leu Leu Val Ile Leu Arg Pro Gly Pro Tyr Ile Cys Ala Glu Trp 
        115                 120                 125             


Glu Met Gly Gly Leu Pro Ser Trp Leu Leu Arg Lys Pro Glu Ile His 
    130                 135                 140                 


Leu Arg Thr Ser Asp Pro Ala Asp Asn Met Thr Lys Ile Phe Thr Leu 
145                 150                 155                 160 


Leu Arg Lys Tyr Glu Pro His Gly Pro Leu Val Asn Ser Glu Tyr Tyr 
                165                 170                 175     


Thr Gly Trp Leu Asp Tyr Trp Gly Gln Asn His Ser Thr Arg Ser Val 
            180                 185                 190         


Ser Ala Val Thr Lys Gly Leu Glu Asn Met Leu Lys Leu Gly Ala Ser 
        195                 200                 205             


Val Asn Met Tyr Met Phe His Gly Gly Thr Asn Phe Gly Tyr Trp Asn 
    210                 215                 220                 


Gly Ala Asp Lys Lys Gly Arg Phe Leu Pro Ile Thr Thr Ser Tyr Asp 
225                 230                 235                 240 


Tyr Asp Ala Pro Ile Ser Glu Ala Gly Asp Pro Thr Pro Lys Leu Phe 
                245                 250                 255     


Ala Leu Arg Asp Val Ile Ser Lys Phe Gln Glu Val Pro Leu Gly Pro 
            260                 265                 270         


Leu Pro Pro Pro Ser Pro Lys Met Met Leu Gly Pro Val Thr Leu His 
        275                 280                 285             


Leu Val Gly His Leu Leu Ala Phe Leu Asp Leu Leu Cys Pro Arg Gly 
    290                 295                 300                 


Pro Ile His Ser Ile Leu Pro Met Thr Phe Glu Ala Val Lys Gln Asp 
305                 310                 315                 320 


His Gly Phe Met Leu Tyr Arg Thr Tyr Met Thr His Thr Ile Phe Glu 
                325                 330                 335     


Pro Thr Pro Phe Trp Val Pro Asn Asn Gly Val His Asp Arg Ala Tyr 
            340                 345                 350         


Val Met Val Asp Gly Val Phe Gln Gly Val Val Glu Arg Asn Met Arg 
        355                 360                 365             


Asp Lys Leu Phe Leu Thr Gly Lys Leu Gly Ser Lys Leu Asp Ile Leu 
    370                 375                 380                 


Val Glu Asn Met Gly Arg Leu Ser Phe Gly Ser Asn Ser Ser Asp Phe 
385                 390                 395                 400 


Lys Gly Leu Leu Lys Pro Pro Ile Leu Gly Gln Thr Ile Leu Thr Gln 
                405                 410                 415     


Trp Met Met Phe Pro Leu Lys Ile Asp Asn Leu Val Lys Trp Trp Phe 
            420                 425                 430         


Pro Leu Gln Leu Pro Lys Trp Pro Tyr Pro Gln Ala Pro Ser Gly Pro 
        435                 440                 445             


Thr Phe Tyr Ser Lys Thr Phe Pro Ile Leu Gly Ser Val Gly Asp Thr 
    450                 455                 460                 


Phe Leu Tyr Leu Pro Gly Trp Thr Lys Gly Gln Val Trp Ile Asn Gly 
465                 470                 475                 480 


Phe Asn Leu Gly Arg Tyr Trp Thr Lys Gln Gly Pro Gln Gln Thr Leu 
                485                 490                 495     


Tyr Val Pro Arg Phe Leu Leu Phe Pro Arg Gly Ala Leu Asn Lys Ile 
            500                 505                 510         


Thr Leu Leu Glu Leu Glu Asp Val Pro Leu Gln Pro Gln Val Gln Phe 
        515                 520                 525             


Leu Asp Lys Pro Ile Leu Asn Ser Thr Ser Thr Leu His Arg Thr His 
    530                 535                 540                 


Ile Asn Ser Leu Ser Ala Asp Thr Leu Ser Ala Ser Glu Pro Met Glu 
545                 550                 555                 560 


Leu Ser Gly His 
                


<210>  5989
<211>  654
<212>  PRT
<213>  Homo Sapiens

<400>  5989

Met Ala Pro Lys Lys Leu Ser Cys Leu Arg Ser Leu Leu Leu Pro Leu 
1               5                   10                  15      


Ser Leu Thr Leu Leu Leu Pro Gln Ala Asp Thr Arg Ser Phe Val Val 
            20                  25                  30          


Asp Arg Gly His Asp Arg Phe Leu Leu Asp Gly Ala Pro Phe Arg Tyr 
        35                  40                  45              


Val Ser Gly Ser Leu His Tyr Phe Arg Val Pro Arg Val Leu Trp Ala 
    50                  55                  60                  


Asp Arg Leu Leu Lys Met Arg Trp Ser Gly Leu Asn Ala Ile Gln Phe 
65                  70                  75                  80  


Tyr Val Pro Trp Asn Tyr His Glu Pro Gln Pro Gly Val Tyr Asn Phe 
                85                  90                  95      


Asn Gly Ser Arg Asp Leu Ile Ala Phe Leu Asn Glu Ala Ala Leu Ala 
            100                 105                 110         


Asn Leu Leu Val Ile Leu Arg Pro Gly Pro Tyr Ile Cys Ala Glu Trp 
        115                 120                 125             


Glu Met Gly Gly Leu Pro Ser Trp Leu Leu Arg Lys Pro Glu Ile His 
    130                 135                 140                 


Leu Arg Thr Ser Asp Pro Asp Phe Leu Ala Ala Val Asp Ser Trp Phe 
145                 150                 155                 160 


Lys Val Leu Leu Pro Lys Ile Tyr Pro Trp Leu Tyr His Asn Gly Gly 
                165                 170                 175     


Asn Ile Ile Ser Ile Gln Val Glu Asn Glu Tyr Gly Ser Tyr Arg Ala 
            180                 185                 190         


Cys Asp Phe Ser Tyr Met Arg His Leu Ala Gly Leu Phe Arg Ala Leu 
        195                 200                 205             


Leu Gly Glu Lys Ile Leu Leu Phe Thr Thr Asp Gly Pro Glu Gly Leu 
    210                 215                 220                 


Lys Cys Gly Ser Leu Arg Gly Leu Tyr Thr Thr Val Asp Phe Gly Pro 
225                 230                 235                 240 


Ala Asp Asn Met Thr Lys Ile Phe Thr Leu Leu Arg Lys Tyr Glu Pro 
                245                 250                 255     


His Gly Pro Leu Val Asn Ser Glu Tyr Tyr Thr Gly Trp Leu Asp Tyr 
            260                 265                 270         


Trp Gly Gln Asn His Ser Thr Arg Ser Val Ser Ala Val Thr Lys Gly 
        275                 280                 285             


Leu Glu Asn Met Leu Lys Leu Gly Ala Ser Val Asn Met Tyr Met Phe 
    290                 295                 300                 


His Gly Gly Thr Asn Phe Gly Tyr Trp Asn Gly Ala Asp Lys Lys Gly 
305                 310                 315                 320 


Arg Phe Leu Pro Ile Thr Thr Ser Tyr Asp Tyr Asp Ala Pro Ile Ser 
                325                 330                 335     


Glu Ala Gly Asp Pro Thr Pro Lys Leu Phe Ala Leu Arg Asp Val Ile 
            340                 345                 350         


Ser Lys Phe Gln Glu Val Pro Leu Gly Pro Leu Pro Pro Pro Ser Pro 
        355                 360                 365             


Lys Met Met Leu Gly Pro Val Thr Leu His Leu Val Gly His Leu Leu 
    370                 375                 380                 


Ala Phe Leu Asp Leu Leu Cys Pro Arg Gly Pro Ile His Ser Ile Leu 
385                 390                 395                 400 


Pro Met Thr Phe Glu Ala Val Lys Gln Asp His Gly Phe Met Leu Tyr 
                405                 410                 415     


Arg Thr Tyr Met Thr His Thr Ile Phe Glu Pro Thr Pro Phe Trp Val 
            420                 425                 430         


Pro Asn Asn Gly Val His Asp Arg Ala Tyr Val Met Val Asp Gly Val 
        435                 440                 445             


Phe Gln Gly Val Val Glu Arg Asn Met Arg Asp Lys Leu Phe Leu Thr 
    450                 455                 460                 


Gly Lys Leu Gly Ser Lys Leu Asp Ile Leu Val Glu Asn Met Gly Arg 
465                 470                 475                 480 


Leu Ser Phe Gly Ser Asn Ser Ser Asp Phe Lys Gly Leu Leu Lys Pro 
                485                 490                 495     


Pro Ile Leu Gly Gln Thr Ile Leu Thr Gln Trp Met Met Phe Pro Leu 
            500                 505                 510         


Lys Ile Asp Asn Leu Val Lys Trp Trp Phe Pro Leu Gln Leu Pro Lys 
        515                 520                 525             


Trp Pro Tyr Pro Gln Ala Pro Ser Gly Pro Thr Phe Tyr Ser Lys Thr 
    530                 535                 540                 


Phe Pro Ile Leu Gly Ser Val Gly Asp Thr Phe Leu Tyr Leu Pro Gly 
545                 550                 555                 560 


Trp Thr Lys Gly Gln Val Trp Ile Asn Gly Phe Asn Leu Gly Arg Tyr 
                565                 570                 575     


Trp Thr Lys Gln Gly Pro Gln Gln Thr Leu Tyr Val Pro Arg Phe Leu 
            580                 585                 590         


Leu Phe Pro Arg Gly Ala Leu Asn Lys Ile Thr Leu Leu Glu Leu Glu 
        595                 600                 605             


Asp Val Pro Leu Gln Pro Gln Val Gln Phe Leu Asp Lys Pro Ile Leu 
    610                 615                 620                 


Asn Ser Thr Ser Thr Leu His Arg Thr His Ile Asn Ser Leu Ser Ala 
625                 630                 635                 640 


Asp Thr Leu Ser Ala Ser Glu Pro Met Glu Leu Ser Gly His 
                645                 650                 


<210>  5990
<211>  654
<212>  PRT
<213>  Homo Sapiens

<400>  5990

Met Ala Pro Lys Lys Leu Ser Cys Leu Arg Ser Leu Leu Leu Pro Leu 
1               5                   10                  15      


Ser Leu Thr Leu Leu Leu Pro Gln Ala Asp Thr Arg Ser Phe Val Val 
            20                  25                  30          


Asp Arg Gly His Asp Arg Phe Leu Leu Asp Gly Ala Pro Phe Arg Tyr 
        35                  40                  45              


Val Ser Gly Ser Leu His Tyr Phe Arg Val Pro Arg Val Leu Trp Ala 
    50                  55                  60                  


Asp Arg Leu Leu Lys Met Arg Trp Ser Gly Leu Asn Ala Ile Gln Phe 
65                  70                  75                  80  


Tyr Val Pro Trp Asn Tyr His Glu Pro Gln Pro Gly Val Tyr Asn Phe 
                85                  90                  95      


Asn Gly Ser Arg Asp Leu Ile Ala Phe Leu Asn Glu Ala Ala Leu Ala 
            100                 105                 110         


Asn Leu Leu Val Ile Leu Arg Pro Gly Pro Tyr Ile Cys Ala Glu Trp 
        115                 120                 125             


Glu Met Gly Gly Leu Pro Ser Trp Leu Leu Arg Lys Pro Glu Ile His 
    130                 135                 140                 


Leu Arg Thr Ser Asp Pro Asp Phe Leu Ala Ala Val Asp Ser Trp Phe 
145                 150                 155                 160 


Lys Val Leu Leu Pro Lys Ile Tyr Pro Trp Leu Tyr His Asn Gly Gly 
                165                 170                 175     


Asn Ile Ile Ser Ile Gln Val Glu Asn Glu Tyr Gly Ser Tyr Arg Ala 
            180                 185                 190         


Cys Asp Phe Ser Tyr Met Arg His Leu Ala Gly Leu Phe Arg Ala Leu 
        195                 200                 205             


Leu Gly Glu Lys Ile Leu Leu Phe Thr Thr Asp Gly Pro Glu Gly Leu 
    210                 215                 220                 


Lys Cys Gly Ser Leu Arg Gly Leu Tyr Thr Thr Val Asp Phe Gly Pro 
225                 230                 235                 240 


Ala Asp Asn Met Thr Lys Ile Phe Thr Leu Leu Arg Lys Tyr Glu Pro 
                245                 250                 255     


His Gly Pro Leu Val Asn Ser Glu Tyr Tyr Thr Gly Trp Leu Asp Tyr 
            260                 265                 270         


Trp Gly Gln Asn His Ser Thr Arg Ser Val Ser Ala Val Thr Lys Gly 
        275                 280                 285             


Leu Glu Asn Met Leu Lys Leu Gly Ala Ser Val Asn Met Tyr Met Phe 
    290                 295                 300                 


His Gly Gly Thr Asn Phe Gly Tyr Trp Asn Gly Ala Asp Lys Lys Gly 
305                 310                 315                 320 


Arg Phe Leu Pro Ile Thr Thr Ser Tyr Asp Tyr Asp Ala Pro Ile Ser 
                325                 330                 335     


Glu Ala Gly Asp Pro Thr Pro Lys Leu Phe Ala Leu Arg Asp Val Ile 
            340                 345                 350         


Ser Lys Phe Gln Glu Val Pro Leu Gly Pro Leu Pro Pro Pro Ser Pro 
        355                 360                 365             


Lys Met Met Leu Gly Pro Val Thr Leu His Leu Val Gly His Leu Leu 
    370                 375                 380                 


Ala Phe Leu Asp Leu Leu Cys Pro Arg Gly Pro Ile His Ser Ile Leu 
385                 390                 395                 400 


Pro Met Thr Phe Glu Ala Val Lys Gln Asp His Gly Phe Met Leu Tyr 
                405                 410                 415     


Arg Thr Tyr Met Thr His Thr Ile Phe Glu Pro Thr Pro Phe Trp Val 
            420                 425                 430         


Pro Asn Asn Gly Val His Asp Arg Ala Tyr Val Met Val Asp Gly Val 
        435                 440                 445             


Phe Gln Gly Val Val Glu Arg Asn Met Arg Asp Lys Leu Phe Leu Thr 
    450                 455                 460                 


Gly Lys Leu Gly Ser Lys Leu Asp Ile Leu Val Glu Asn Met Gly Arg 
465                 470                 475                 480 


Leu Ser Phe Gly Ser Asn Ser Ser Asp Phe Lys Gly Leu Leu Lys Pro 
                485                 490                 495     


Pro Ile Leu Gly Gln Thr Ile Leu Thr Gln Trp Met Met Phe Pro Leu 
            500                 505                 510         


Lys Ile Asp Asn Leu Val Lys Trp Trp Phe Pro Leu Gln Leu Pro Lys 
        515                 520                 525             


Trp Pro Tyr Pro Gln Ala Pro Ser Gly Pro Thr Phe Tyr Ser Lys Thr 
    530                 535                 540                 


Phe Pro Ile Leu Gly Ser Val Gly Asp Thr Phe Leu Tyr Leu Pro Gly 
545                 550                 555                 560 


Trp Thr Lys Gly Gln Val Trp Ile Asn Gly Phe Asn Leu Gly Arg Tyr 
                565                 570                 575     


Trp Thr Lys Gln Gly Pro Gln Gln Thr Leu Tyr Val Pro Arg Phe Leu 
            580                 585                 590         


Leu Phe Pro Arg Gly Ala Leu Asn Lys Ile Thr Leu Leu Glu Leu Glu 
        595                 600                 605             


Asp Val Pro Leu Gln Pro Gln Val Gln Phe Leu Asp Lys Pro Ile Leu 
    610                 615                 620                 


Asn Ser Thr Ser Thr Leu His Arg Thr His Ile Asn Ser Leu Ser Ala 
625                 630                 635                 640 


Asp Thr Leu Ser Ala Ser Glu Pro Met Glu Leu Ser Gly His 
                645                 650                 


<210>  5991
<211>  50
<212>  PRT
<213>  Homo Sapiens

<400>  5991

Met Ala Pro Lys Lys Leu Ser Cys Leu Arg Ser Leu Leu Leu Pro Leu 
1               5                   10                  15      


Ser Leu Thr Leu Leu Leu Pro Gln Thr Gly Pro Arg Ser Ala Met Cys 
            20                  25                  30          


Leu Ala Ala Cys Thr Thr Phe Gly Tyr Arg Gly Cys Phe Gly Pro Thr 
        35                  40                  45              


Gly Phe 
    50  


<210>  5992
<211>  185
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  5992

Xaa Lys Met Arg Trp Ser Gly Leu Asn Ala Ile Gln Phe Tyr Val Pro 
1               5                   10                  15      


Trp Asn Tyr His Glu Pro Gln Pro Gly Val Tyr Asn Phe Asn Gly Ser 
            20                  25                  30          


Arg Asp Leu Ile Ala Phe Leu Asn Glu Ala Ala Leu Ala Asn Leu Leu 
        35                  40                  45              


Val Ile Leu Arg Pro Gly Pro Tyr Ile Cys Ala Glu Trp Glu Met Gly 
    50                  55                  60                  


Gly Leu Pro Ser Trp Leu Leu Arg Lys Pro Glu Ile His Leu Arg Thr 
65                  70                  75                  80  


Ser Asp Pro Asp Phe Leu Ala Ala Val Asp Ser Trp Phe Lys Val Leu 
                85                  90                  95      


Leu Pro Lys Ile Tyr Pro Trp Leu Tyr His Asn Gly Gly Asn Ile Ile 
            100                 105                 110         


Ser Ile Gln Val Glu Asn Glu Tyr Gly Ser Tyr Arg Ala Cys Asp Phe 
        115                 120                 125             


Ser Tyr Met Arg His Leu Ala Gly Leu Phe Arg Ala Leu Leu Gly Glu 
    130                 135                 140                 


Lys Ile Leu Leu Phe Thr Thr Asp Gly Pro Glu Gly Leu Lys Cys Gly 
145                 150                 155                 160 


Ser Leu Arg Gly Leu Tyr Thr Thr Val Asp Phe Gly Pro Gly Leu Lys 
                165                 170                 175     


Gln Gly Leu Gly Val Glu Ser Gly Glu 
            180                 185 


<210>  5993
<211>  636
<212>  PRT
<213>  Homo Sapiens

<400>  5993

Met Thr Thr Trp Ser Leu Arg Arg Arg Pro Ala Arg Thr Leu Gly Leu 
1               5                   10                  15      


Leu Leu Leu Val Val Leu Gly Phe Leu Val Leu Arg Arg Leu Asp Trp 
            20                  25                  30          


Ser Thr Leu Val Pro Leu Arg Leu Arg His Arg Gln Leu Gly Leu Gln 
        35                  40                  45              


Ala Lys Gly Trp Asn Phe Met Leu Glu Asp Ser Thr Phe Trp Ile Phe 
    50                  55                  60                  


Gly Gly Ser Ile His Tyr Phe Arg Val Pro Arg Glu Tyr Trp Arg Asp 
65                  70                  75                  80  


Arg Leu Leu Lys Met Lys Ala Cys Gly Leu Asn Thr Leu Thr Thr Tyr 
                85                  90                  95      


Val Pro Trp Asn Leu His Glu Pro Glu Arg Gly Lys Phe Asp Phe Ser 
            100                 105                 110         


Gly Asn Leu Asp Leu Glu Ala Phe Val Leu Met Ala Ala Glu Ile Gly 
        115                 120                 125             


Leu Trp Val Ile Leu Arg Pro Gly Pro Tyr Ile Cys Ser Glu Met Asp 
    130                 135                 140                 


Leu Gly Gly Leu Pro Ser Trp Leu Leu Gln Asp Pro Gly Met Arg Leu 
145                 150                 155                 160 


Arg Thr Thr Tyr Lys Gly Phe Thr Glu Ala Val Asp Leu Tyr Phe Asp 
                165                 170                 175     


His Leu Met Ser Arg Val Val Pro Leu Gln Tyr Lys Arg Gly Gly Pro 
            180                 185                 190         


Ile Ile Ala Val Gln Val Glu Asn Glu Tyr Gly Ser Tyr Asn Lys Asp 
        195                 200                 205             


Pro Ala Tyr Met Pro Tyr Val Lys Lys Ala Leu Glu Asp Arg Gly Ile 
    210                 215                 220                 


Val Glu Leu Leu Leu Thr Ser Asp Asn Lys Asp Gly Leu Ser Lys Gly 
225                 230                 235                 240 


Ile Val Gln Gly Val Leu Ala Thr Ile Asn Leu Gln Ser Thr His Glu 
                245                 250                 255     


Leu Gln Leu Leu Thr Thr Phe Leu Phe Asn Val Gln Gly Thr Gln Pro 
            260                 265                 270         


Lys Met Val Met Glu Tyr Trp Thr Gly Trp Phe Asp Ser Trp Gly Gly 
        275                 280                 285             


Pro His Asn Ile Leu Asp Ser Ser Glu Val Leu Lys Thr Val Ser Ala 
    290                 295                 300                 


Ile Val Asp Ala Gly Ser Ser Ile Asn Leu Tyr Met Phe His Gly Gly 
305                 310                 315                 320 


Thr Asn Phe Gly Phe Met Asn Gly Ala Met His Phe His Asp Tyr Lys 
                325                 330                 335     


Ser Asp Val Thr Ser Tyr Asp Tyr Asp Ala Val Leu Thr Glu Ala Gly 
            340                 345                 350         


Asp Tyr Thr Ala Lys Tyr Met Lys Leu Arg Asp Phe Phe Gly Ser Ile 
        355                 360                 365             


Ser Gly Ile Pro Leu Pro Pro Pro Pro Asp Leu Leu Pro Lys Met Pro 
    370                 375                 380                 


Tyr Glu Pro Leu Thr Pro Val Leu Tyr Leu Ser Leu Trp Asp Ala Leu 
385                 390                 395                 400 


Lys Tyr Leu Gly Glu Pro Ile Lys Ser Glu Lys Pro Ile Asn Met Glu 
                405                 410                 415     


Asn Leu Pro Val Asn Gly Gly Asn Gly Gln Ser Phe Gly Tyr Ile Leu 
            420                 425                 430         


Tyr Glu Thr Ser Ile Thr Ser Ser Gly Ile Leu Ser Gly His Val His 
        435                 440                 445             


Asp Arg Gly Gln Val Phe Val Asn Thr Val Ser Ile Gly Phe Leu Asp 
    450                 455                 460                 


Tyr Lys Thr Thr Lys Ile Ala Val Pro Leu Ile Gln Gly Tyr Thr Val 
465                 470                 475                 480 


Leu Arg Ile Leu Val Glu Asn Arg Gly Arg Val Asn Tyr Gly Glu Asn 
                485                 490                 495     


Ile Asp Asp Gln Arg Lys Gly Leu Ile Gly Asn Leu Tyr Leu Asn Asp 
            500                 505                 510         


Ser Pro Leu Lys Asn Phe Arg Ile Tyr Ser Leu Asp Met Lys Lys Ser 
        515                 520                 525             


Phe Phe Gln Arg Phe Gly Leu Asp Lys Trp Ser Ser Leu Pro Glu Thr 
    530                 535                 540                 


Pro Thr Leu Pro Ala Phe Phe Leu Gly Ser Leu Ser Ile Ser Ser Thr 
545                 550                 555                 560 


Pro Cys Asp Thr Phe Leu Lys Leu Glu Gly Trp Glu Lys Gly Val Val 
                565                 570                 575     


Phe Ile Asn Gly Gln Asn Leu Gly Arg Tyr Trp Asn Ile Gly Pro Gln 
            580                 585                 590         


Lys Thr Leu Tyr Leu Pro Gly Pro Trp Leu Ser Ser Gly Ile Asn Gln 
        595                 600                 605             


Val Ile Val Phe Glu Glu Thr Met Ala Gly Pro Ala Leu Gln Phe Thr 
    610                 615                 620                 


Glu Thr Pro His Leu Gly Arg Asn Gln Tyr Ile Lys 
625                 630                 635     


<210>  5994
<211>  636
<212>  PRT
<213>  Homo Sapiens

<400>  5994

Met Thr Thr Trp Ser Leu Arg Arg Arg Pro Ala Arg Thr Leu Gly Leu 
1               5                   10                  15      


Leu Leu Leu Val Val Leu Gly Phe Leu Val Leu Arg Arg Leu Asp Trp 
            20                  25                  30          


Ser Thr Leu Val Pro Leu Arg Leu Arg His Arg Gln Leu Gly Leu Gln 
        35                  40                  45              


Ala Lys Gly Trp Asn Phe Met Leu Glu Asp Ser Thr Phe Trp Ile Phe 
    50                  55                  60                  


Gly Gly Ser Ile His Tyr Phe Arg Val Pro Arg Glu Tyr Trp Arg Asp 
65                  70                  75                  80  


Arg Leu Leu Lys Met Lys Ala Cys Gly Leu Asn Thr Leu Thr Thr Tyr 
                85                  90                  95      


Val Pro Trp Asn Leu His Glu Pro Glu Arg Gly Lys Phe Asp Phe Ser 
            100                 105                 110         


Gly Asn Leu Asp Leu Glu Ala Phe Val Leu Met Ala Ala Glu Ile Gly 
        115                 120                 125             


Leu Trp Val Ile Leu Arg Pro Gly Pro Tyr Ile Cys Ser Glu Met Asp 
    130                 135                 140                 


Leu Gly Gly Leu Pro Ser Trp Leu Leu Gln Asp Pro Gly Met Arg Leu 
145                 150                 155                 160 


Arg Thr Thr Tyr Lys Gly Phe Thr Glu Ala Val Asp Leu Tyr Phe Asp 
                165                 170                 175     


His Leu Met Ser Arg Val Val Pro Leu Gln Tyr Lys Arg Gly Gly Pro 
            180                 185                 190         


Ile Ile Ala Val Gln Val Glu Asn Glu Tyr Gly Ser Tyr Asn Lys Asp 
        195                 200                 205             


Pro Ala Tyr Met Pro Tyr Val Lys Lys Ala Leu Glu Asp Arg Gly Ile 
    210                 215                 220                 


Val Glu Leu Leu Leu Thr Ser Asp Asn Lys Asp Gly Leu Ser Lys Gly 
225                 230                 235                 240 


Ile Val Gln Gly Val Leu Ala Thr Ile Asn Leu Gln Ser Thr His Glu 
                245                 250                 255     


Leu Gln Leu Leu Thr Thr Phe Leu Phe Asn Val Gln Gly Thr Gln Pro 
            260                 265                 270         


Lys Met Val Met Glu Tyr Trp Thr Gly Trp Phe Asp Ser Trp Gly Gly 
        275                 280                 285             


Pro His Asn Ile Leu Asp Ser Ser Glu Val Leu Lys Thr Val Ser Ala 
    290                 295                 300                 


Ile Val Asp Ala Gly Ser Ser Ile Asn Leu Tyr Met Phe His Gly Gly 
305                 310                 315                 320 


Thr Asn Phe Gly Phe Met Asn Gly Ala Met His Phe His Asp Tyr Lys 
                325                 330                 335     


Ser Asp Val Thr Ser Tyr Asp Tyr Asp Ala Val Leu Thr Glu Ala Gly 
            340                 345                 350         


Asp Tyr Thr Ala Lys Tyr Met Lys Leu Arg Asp Phe Phe Gly Ser Ile 
        355                 360                 365             


Ser Gly Ile Pro Leu Pro Pro Pro Pro Asp Leu Leu Pro Lys Met Pro 
    370                 375                 380                 


Tyr Glu Pro Leu Thr Pro Val Leu Tyr Leu Ser Leu Trp Asp Ala Leu 
385                 390                 395                 400 


Lys Tyr Leu Gly Glu Pro Ile Lys Ser Glu Lys Pro Ile Asn Met Glu 
                405                 410                 415     


Asn Leu Pro Val Asn Gly Gly Asn Gly Gln Ser Phe Gly Tyr Ile Leu 
            420                 425                 430         


Tyr Glu Thr Ser Ile Thr Ser Ser Gly Ile Leu Ser Gly His Val His 
        435                 440                 445             


Asp Arg Gly Gln Val Phe Val Asn Thr Val Ser Ile Gly Phe Leu Asp 
    450                 455                 460                 


Tyr Lys Thr Thr Lys Ile Ala Val Pro Leu Ile Gln Gly Tyr Thr Val 
465                 470                 475                 480 


Leu Arg Ile Leu Val Glu Asn Arg Gly Arg Val Asn Tyr Gly Glu Asn 
                485                 490                 495     


Ile Asp Asp Gln Arg Lys Gly Leu Ile Gly Asn Leu Tyr Leu Asn Asp 
            500                 505                 510         


Ser Pro Leu Lys Asn Phe Arg Ile Tyr Ser Leu Asp Met Lys Lys Ser 
        515                 520                 525             


Phe Phe Gln Arg Phe Gly Leu Asp Lys Trp Ser Ser Leu Pro Glu Thr 
    530                 535                 540                 


Pro Thr Leu Pro Ala Phe Phe Leu Gly Ser Leu Ser Ile Ser Ser Thr 
545                 550                 555                 560 


Pro Cys Asp Thr Phe Leu Lys Leu Glu Gly Trp Glu Lys Gly Val Val 
                565                 570                 575     


Phe Ile Asn Gly Gln Asn Leu Gly Arg Tyr Trp Asn Ile Gly Pro Gln 
            580                 585                 590         


Lys Thr Leu Tyr Leu Pro Gly Pro Trp Leu Ser Ser Gly Ile Asn Gln 
        595                 600                 605             


Val Ile Val Phe Glu Glu Thr Met Ala Gly Pro Ala Leu Gln Phe Thr 
    610                 615                 620                 


Glu Thr Pro His Leu Gly Arg Asn Gln Tyr Ile Lys 
625                 630                 635     


<210>  5995
<211>  553
<212>  PRT
<213>  Homo Sapiens

<400>  5995

Met Asn His Val Ala Lys Gln Gln Ser Glu Glu Ala Phe Pro Gln Glu 
1               5                   10                  15      


Gln Gln Lys Ala Pro Pro Val Val Gly Gly Phe Asn Ser Asn Val Gly 
            20                  25                  30          


Ser Lys Val Leu Gly Leu Lys Tyr Glu Glu Ile Asp Cys Leu Ile Asn 
        35                  40                  45              


Asp Glu His Thr Ile Lys Gly Arg Arg Glu Gly Asn Glu Val Phe Leu 
    50                  55                  60                  


Pro Phe Thr Trp Val Glu Lys Tyr Phe Asp Val Tyr Gly Lys Val Val 
65                  70                  75                  80  


Gln Tyr Asp Gly Tyr Asp Arg Phe Glu Phe Ser His Ser Tyr Ser Lys 
                85                  90                  95      


Val Tyr Ala Gln Arg Ala Pro Tyr His Pro Asp Gly Val Phe Met Ser 
            100                 105                 110         


Phe Glu Gly Tyr Asn Val Glu Val Arg Asp Arg Val Lys Cys Ile Ser 
        115                 120                 125             


Gly Val Glu Gly Val Pro Leu Ser Thr Gln Trp Gly Pro Gln Gly Tyr 
    130                 135                 140                 


Phe Tyr Pro Ile Gln Ile Ala Gln Tyr Gly Leu Ser His Tyr Ser Lys 
145                 150                 155                 160 


Asn Leu Thr Glu Lys Pro Pro His Ile Glu Val Tyr Glu Thr Ala Glu 
                165                 170                 175     


Asp Arg Asp Lys Asn Lys Pro Asn Asp Trp Thr Val Pro Lys Gly Cys 
            180                 185                 190         


Phe Met Ala Asn Val Ala Asp Lys Ser Arg Phe Thr Asn Val Lys Gln 
        195                 200                 205             


Phe Ile Ala Pro Glu Thr Ser Glu Gly Val Ser Leu Gln Leu Gly Asn 
    210                 215                 220                 


Thr Lys Asp Phe Ile Ile Ser Phe Asp Leu Lys Phe Leu Thr Asn Gly 
225                 230                 235                 240 


Ser Val Ser Val Val Leu Glu Thr Thr Glu Lys Asn Gln Leu Phe Thr 
                245                 250                 255     


Ile His Tyr Val Ser Asn Ala Gln Leu Ile Ala Phe Lys Glu Arg Asp 
            260                 265                 270         


Ile Tyr Tyr Gly Ile Gly Pro Arg Thr Ser Trp Ser Thr Val Thr Arg 
        275                 280                 285             


Asp Leu Val Thr Asp Leu Arg Lys Gly Val Gly Leu Ser Asn Thr Lys 
    290                 295                 300                 


Ala Val Lys Pro Thr Lys Ile Met Pro Lys Lys Val Val Arg Leu Ile 
305                 310                 315                 320 


Ala Lys Gly Lys Gly Phe Leu Asp Asn Ile Thr Ile Ser Thr Thr Ala 
                325                 330                 335     


His Met Ala Ala Phe Phe Ala Ala Ser Asp Trp Leu Val Arg Asn Gln 
            340                 345                 350         


Asp Glu Lys Gly Gly Trp Pro Ile Met Val Thr Arg Lys Leu Gly Glu 
        355                 360                 365             


Gly Phe Lys Ser Leu Glu Pro Gly Trp Tyr Ser Ala Met Ala Gln Gly 
    370                 375                 380                 


Gln Ala Ile Ser Thr Leu Val Arg Ala Tyr Leu Leu Thr Lys Asp His 
385                 390                 395                 400 


Ile Phe Leu Asn Ser Ala Leu Arg Ala Thr Ala Pro Tyr Lys Phe Leu 
                405                 410                 415     


Ser Glu Gln His Gly Val Lys Ala Val Phe Met Asn Lys His Asp Trp 
            420                 425                 430         


Tyr Glu Glu Tyr Pro Thr Thr Pro Ser Ser Phe Val Leu Asn Gly Phe 
        435                 440                 445             


Met Tyr Ser Leu Ile Gly Leu Tyr Asp Leu Lys Glu Thr Ala Gly Glu 
    450                 455                 460                 


Lys Leu Gly Lys Glu Ala Arg Ser Leu Tyr Glu Arg Gly Met Glu Ser 
465                 470                 475                 480 


Leu Lys Ala Met Leu Pro Leu Tyr Asp Thr Gly Ser Gly Thr Ile Tyr 
                485                 490                 495     


Asp Leu Arg His Phe Met Leu Gly Ile Ala Pro Asn Leu Ala Arg Trp 
            500                 505                 510         


Asp Tyr His Thr Thr His Ile Asn Gln Leu Gln Leu Leu Ser Thr Ile 
        515                 520                 525             


Asp Glu Ser Pro Val Phe Lys Glu Phe Val Lys Arg Trp Lys Ser Tyr 
    530                 535                 540                 


Leu Lys Gly Ser Arg Ala Lys His Asn 
545                 550             


<210>  5996
<211>  617
<212>  PRT
<213>  Homo Sapiens

<400>  5996

Met Arg Cys Leu Ala Ala Arg Val Asn Tyr Lys Thr Leu Ile Ile Ile 
1               5                   10                  15      


Cys Ala Leu Phe Thr Leu Val Thr Val Leu Leu Trp Asn Lys Cys Ser 
            20                  25                  30          


Ser Asp Lys Ala Ile Gln Phe Pro Arg Arg Ser Ser Ser Gly Phe Arg 
        35                  40                  45              


Val Asp Gly Phe Glu Lys Arg Ala Ala Ala Ser Glu Ser Asn Asn Tyr 
    50                  55                  60                  


Met Asn His Val Ala Lys Gln Gln Ser Glu Glu Ala Phe Pro Gln Glu 
65                  70                  75                  80  


Gln Gln Lys Ala Pro Pro Val Val Gly Gly Phe Asn Ser Asn Val Gly 
                85                  90                  95      


Ser Lys Val Leu Gly Leu Lys Tyr Glu Glu Ile Asp Cys Leu Ile Asn 
            100                 105                 110         


Asp Glu His Thr Ile Lys Gly Arg Arg Glu Gly Asn Glu Val Phe Leu 
        115                 120                 125             


Pro Phe Thr Trp Val Glu Lys Tyr Phe Asp Val Tyr Gly Lys Val Val 
    130                 135                 140                 


Gln Tyr Asp Gly Tyr Asp Arg Phe Glu Phe Ser His Ser Tyr Ser Lys 
145                 150                 155                 160 


Val Tyr Ala Gln Arg Ala Pro Tyr His Pro Asp Gly Val Phe Met Ser 
                165                 170                 175     


Phe Glu Gly Tyr Asn Val Glu Val Arg Asp Arg Val Lys Cys Ile Ser 
            180                 185                 190         


Gly Val Glu Gly Val Pro Leu Ser Thr Gln Trp Gly Pro Gln Gly Tyr 
        195                 200                 205             


Phe Tyr Pro Ile Gln Ile Ala Gln Tyr Gly Leu Ser His Tyr Ser Lys 
    210                 215                 220                 


Asn Leu Thr Glu Lys Pro Pro His Ile Glu Val Tyr Glu Thr Ala Glu 
225                 230                 235                 240 


Asp Arg Asp Lys Asn Lys Pro Asn Asp Trp Thr Val Pro Lys Gly Cys 
                245                 250                 255     


Phe Met Ala Asn Val Ala Asp Lys Ser Arg Phe Thr Asn Val Lys Gln 
            260                 265                 270         


Phe Ile Ala Pro Glu Thr Ser Glu Gly Val Ser Leu Gln Leu Gly Asn 
        275                 280                 285             


Thr Lys Asp Phe Ile Ile Ser Phe Asp Leu Lys Phe Leu Thr Asn Gly 
    290                 295                 300                 


Ser Val Ser Val Val Leu Glu Thr Thr Glu Lys Asn Gln Leu Phe Thr 
305                 310                 315                 320 


Ile His Tyr Val Ser Asn Ala Gln Leu Ile Ala Phe Lys Glu Arg Asp 
                325                 330                 335     


Ile Tyr Tyr Gly Ile Gly Pro Arg Thr Ser Trp Ser Thr Val Thr Arg 
            340                 345                 350         


Asp Leu Val Thr Asp Leu Arg Lys Gly Val Gly Leu Ser Asn Thr Lys 
        355                 360                 365             


Ala Val Lys Pro Thr Lys Ile Met Pro Lys Lys Val Val Arg Leu Ile 
    370                 375                 380                 


Ala Lys Gly Lys Gly Phe Leu Asp Asn Ile Thr Ile Ser Thr Thr Ala 
385                 390                 395                 400 


His Met Ala Ala Phe Phe Ala Ala Ser Asp Trp Leu Val Arg Asn Gln 
                405                 410                 415     


Asp Glu Lys Gly Gly Trp Pro Ile Met Val Thr Arg Lys Leu Gly Glu 
            420                 425                 430         


Gly Phe Lys Ser Leu Glu Pro Gly Trp Tyr Ser Ala Met Ala Gln Gly 
        435                 440                 445             


Gln Ala Ile Ser Thr Leu Val Arg Ala Tyr Leu Leu Thr Lys Asp His 
    450                 455                 460                 


Ile Phe Leu Asn Ser Ala Leu Arg Ala Thr Ala Pro Tyr Lys Phe Leu 
465                 470                 475                 480 


Ser Glu Gln His Gly Val Lys Ala Val Phe Met Asn Lys His Asp Trp 
                485                 490                 495     


Tyr Glu Glu Tyr Pro Thr Thr Pro Ser Ser Phe Val Leu Asn Gly Phe 
            500                 505                 510         


Met Tyr Ser Leu Ile Gly Leu Tyr Asp Leu Lys Glu Thr Ala Gly Glu 
        515                 520                 525             


Lys Leu Gly Lys Glu Ala Arg Ser Leu Tyr Glu Arg Gly Met Glu Ser 
    530                 535                 540                 


Leu Lys Ala Met Leu Pro Leu Tyr Asp Thr Gly Ser Gly Thr Ile Tyr 
545                 550                 555                 560 


Asp Leu Arg His Phe Met Leu Gly Ile Ala Pro Asn Leu Ala Arg Trp 
                565                 570                 575     


Asp Tyr His Thr Thr His Ile Asn Gln Leu Gln Leu Leu Ser Thr Ile 
            580                 585                 590         


Asp Glu Ser Pro Val Phe Lys Glu Phe Val Lys Arg Trp Lys Ser Tyr 
        595                 600                 605             


Leu Lys Gly Ser Arg Ala Lys His Asn 
    610                 615         


<210>  5997
<211>  1192
<212>  PRT
<213>  Homo Sapiens

<400>  5997

Met Ala Ala Cys Gly Arg Val Arg Arg Met Phe Arg Leu Ser Ala Ala 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Phe Ala Ala Gly Ala Glu Lys Leu Pro Gly 
            20                  25                  30          


Gln Gly Val His Ser Gln Gly Gln Gly Pro Gly Ala Asn Phe Val Ser 
        35                  40                  45              


Phe Val Gly Gln Ala Gly Gly Gly Gly Pro Ala Gly Gln Gln Leu Pro 
    50                  55                  60                  


Gln Leu Pro Gln Ser Ser Gln Leu Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Gln Gln Gln Gln Pro Gln Pro Pro Gln Pro Pro Phe Pro Ala Gly Gly 
                85                  90                  95      


Pro Pro Ala Arg Arg Gly Gly Ala Gly Ala Gly Gly Gly Trp Lys Leu 
            100                 105                 110         


Ala Glu Glu Glu Ser Cys Arg Glu Asp Val Thr Arg Val Cys Pro Lys 
        115                 120                 125             


His Thr Trp Ser Asn Asn Leu Ala Val Leu Glu Cys Leu Gln Asp Val 
    130                 135                 140                 


Arg Glu Leu Leu Trp Asn Tyr Lys Leu Asn Leu Thr Thr Asp Pro Lys 
145                 150                 155                 160 


Phe Glu Ser Val Ala Arg Glu Val Cys Lys Ser Thr Ile Thr Glu Ile 
                165                 170                 175     


Lys Glu Cys Ala Asp Glu Pro Val Gly Lys Gly Tyr Met Val Ser Cys 
            180                 185                 190         


Leu Val Asp His Arg Gly Asn Ile Thr Glu Tyr Gln Cys His Gln Tyr 
        195                 200                 205             


Ile Thr Lys Met Thr Ala Ile Ile Phe Ser Asp Tyr Arg Leu Ile Cys 
    210                 215                 220                 


Gly Phe Met Asp Asp Cys Lys Asn Asp Ile Asn Ile Leu Lys Cys Gly 
225                 230                 235                 240 


Ser Ile Arg Leu Gly Glu Lys Asp Ala His Ser Gln Gly Glu Val Val 
                245                 250                 255     


Ser Cys Leu Glu Lys Gly Leu Val Lys Glu Ala Glu Glu Arg Glu Pro 
            260                 265                 270         


Lys Ile Gln Val Ser Glu Leu Cys Lys Lys Ala Ile Leu Arg Val Ala 
        275                 280                 285             


Glu Leu Ser Ser Asp Asp Phe His Leu Asp Arg His Leu Tyr Phe Ala 
    290                 295                 300                 


Cys Arg Asp Asp Arg Glu Arg Phe Cys Glu Asn Thr Gln Ala Gly Glu 
305                 310                 315                 320 


Gly Arg Val Tyr Lys Cys Leu Phe Asn His Lys Phe Glu Glu Ser Met 
                325                 330                 335     


Ser Glu Lys Cys Arg Glu Ala Leu Thr Thr Arg Gln Lys Leu Ile Ala 
            340                 345                 350         


Gln Asp Tyr Lys Val Ser Tyr Ser Leu Ala Lys Ser Cys Lys Ser Asp 
        355                 360                 365             


Leu Lys Lys Tyr Arg Cys Asn Val Glu Asn Leu Pro Arg Ser Arg Glu 
    370                 375                 380                 


Ala Arg Leu Ser Tyr Leu Leu Met Cys Leu Glu Ser Ala Val His Arg 
385                 390                 395                 400 


Gly Arg Gln Val Ser Ser Glu Cys Gln Gly Glu Met Leu Asp Tyr Arg 
                405                 410                 415     


Arg Met Leu Met Glu Asp Phe Ser Leu Ser Pro Glu Ile Ile Leu Ser 
            420                 425                 430         


Cys Arg Gly Glu Ile Glu His His Cys Ser Gly Leu His Arg Lys Gly 
        435                 440                 445             


Arg Thr Leu His Cys Leu Met Lys Val Val Arg Gly Glu Lys Gly Asn 
    450                 455                 460                 


Leu Gly Met Asn Cys Gln Gln Ala Leu Gln Thr Leu Ile Gln Glu Thr 
465                 470                 475                 480 


Asp Pro Gly Ala Asp Tyr Arg Ile Asp Arg Ala Leu Asn Glu Ala Cys 
                485                 490                 495     


Glu Ser Val Ile Gln Thr Ala Cys Lys His Ile Arg Ser Gly Asp Pro 
            500                 505                 510         


Met Ile Leu Ser Cys Leu Met Glu His Leu Tyr Thr Glu Lys Met Val 
        515                 520                 525             


Glu Asp Cys Glu His Arg Leu Leu Glu Leu Gln Tyr Phe Ile Ser Arg 
    530                 535                 540                 


Asp Trp Lys Leu Asp Pro Val Leu Tyr Arg Lys Cys Gln Gly Asp Ala 
545                 550                 555                 560 


Ser Arg Leu Cys His Thr His Gly Trp Asn Glu Thr Ser Glu Phe Met 
                565                 570                 575     


Pro Gln Gly Ala Val Phe Ser Cys Leu Tyr Arg His Ala Tyr Arg Thr 
            580                 585                 590         


Glu Glu Gln Gly Arg Arg Leu Ser Arg Glu Cys Arg Ala Glu Val Gln 
        595                 600                 605             


Arg Ile Leu His Gln Arg Ala Met Asp Val Lys Leu Asp Pro Ala Leu 
    610                 615                 620                 


Gln Asp Lys Cys Leu Ile Asp Leu Gly Lys Trp Cys Ser Glu Lys Thr 
625                 630                 635                 640 


Glu Thr Gly Gln Glu Leu Glu Cys Leu Gln Asp His Leu Asp Asp Leu 
                645                 650                 655     


Val Val Glu Cys Arg Asp Ile Val Gly Asn Leu Thr Glu Leu Glu Ser 
            660                 665                 670         


Glu Asp Ile Gln Ile Glu Ala Leu Leu Met Arg Ala Cys Glu Pro Ile 
        675                 680                 685             


Ile Gln Asn Phe Cys His Asp Val Ala Asp Asn Gln Ile Asp Ser Gly 
    690                 695                 700                 


Asp Leu Met Glu Cys Leu Ile Gln Asn Lys His Gln Lys Asp Met Asn 
705                 710                 715                 720 


Glu Lys Cys Ala Ile Gly Val Thr His Phe Gln Leu Val Gln Met Lys 
                725                 730                 735     


Asp Phe Arg Phe Ser Tyr Lys Phe Lys Met Ala Cys Lys Glu Asp Val 
            740                 745                 750         


Leu Lys Leu Cys Pro Asn Ile Lys Lys Lys Val Asp Val Val Ile Cys 
        755                 760                 765             


Leu Ser Thr Thr Val Arg Asn Asp Thr Leu Gln Glu Ala Lys Glu His 
    770                 775                 780                 


Arg Val Ser Leu Lys Cys Arg Arg Gln Leu Arg Val Glu Glu Leu Glu 
785                 790                 795                 800 


Met Thr Glu Asp Ile Arg Leu Glu Pro Asp Leu Tyr Glu Ala Cys Lys 
                805                 810                 815     


Ser Asp Ile Lys Asn Phe Cys Ser Ala Val Gln Tyr Gly Asn Ala Gln 
            820                 825                 830         


Ile Ile Glu Cys Leu Lys Glu Asn Lys Lys Gln Leu Ser Thr Arg Cys 
        835                 840                 845             


His Gln Lys Val Phe Lys Leu Gln Glu Thr Glu Met Met Asp Pro Glu 
    850                 855                 860                 


Leu Asp Tyr Thr Leu Met Arg Val Cys Lys Gln Met Ile Lys Arg Phe 
865                 870                 875                 880 


Cys Pro Glu Ala Asp Ser Lys Thr Met Leu Gln Cys Leu Lys Gln Asn 
                885                 890                 895     


Lys Asn Ser Glu Leu Met Asp Pro Lys Cys Lys Gln Met Ile Thr Lys 
            900                 905                 910         


Arg Gln Ile Thr Gln Asn Thr Asp Tyr Arg Leu Asn Pro Met Leu Arg 
        915                 920                 925             


Lys Ala Cys Lys Ala Asp Ile Pro Lys Phe Cys His Gly Ile Leu Thr 
    930                 935                 940                 


Lys Ala Lys Asp Asp Ser Glu Leu Glu Gly Gln Val Ile Ser Cys Leu 
945                 950                 955                 960 


Lys Leu Arg Tyr Ala Asp Gln Arg Leu Ser Ser Asp Cys Glu Asp Gln 
                965                 970                 975     


Ile Arg Ile Ile Ile Gln Glu Ser Ala Leu Asp Tyr Arg Leu Asp Pro 
            980                 985                 990         


Gln Leu Gln Leu His Cys Ser Asp  Glu Ile Ser Ser Leu  Cys Ala Glu 
        995                 1000                 1005             


Glu Ala  Ala Ala Gln Glu Gln  Thr Gly Gln Val Glu  Glu Cys Leu 
    1010                 1015                 1020             


Lys Val  Asn Leu Leu Lys Ile  Lys Thr Glu Leu Cys  Lys Lys Glu 
    1025                 1030                 1035             


Val Leu  Asn Met Leu Lys Glu  Ser Lys Ala Asp Ile  Phe Val Asp 
    1040                 1045                 1050             


Pro Val  Leu His Thr Ala Cys  Ala Leu Asp Ile Lys  His His Cys 
    1055                 1060                 1065             


Ala Ala  Ile Thr Pro Gly Arg  Gly Arg Gln Met Ser  Cys Leu Met 
    1070                 1075                 1080             


Glu Ala  Leu Glu Asp Lys Arg  Val Arg Leu Gln Pro  Glu Cys Lys 
    1085                 1090                 1095             


Lys Arg  Leu Asn Asp Arg Ile  Glu Met Trp Ser Tyr  Ala Ala Lys 
    1100                 1105                 1110             


Val Ala  Pro Ala Asp Gly Phe  Ser Asp Leu Ala Met  Gln Val Met 
    1115                 1120                 1125             


Thr Ser  Pro Ser Lys Asn Tyr  Ile Leu Ser Val Ile  Ser Gly Ser 
    1130                 1135                 1140             


Ile Cys  Ile Leu Phe Leu Ile  Gly Leu Met Cys Gly  Arg Ile Thr 
    1145                 1150                 1155             


Lys Arg  Val Thr Arg Glu Leu  Lys Asp Arg Leu Gln  Tyr Arg Ser 
    1160                 1165                 1170             


Glu Thr  Met Ala Tyr Lys Gly  Leu Val Trp Ser Gln  Asp Val Thr 
    1175                 1180                 1185             


Gly Ser  Pro Ala 
    1190         


<210>  5998
<211>  1203
<212>  PRT
<213>  Homo Sapiens

<400>  5998

Met Ala Ala Cys Gly Arg Val Arg Arg Met Phe Arg Leu Ser Ala Ala 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Phe Ala Ala Gly Ala Glu Lys Leu Pro Gly 
            20                  25                  30          


Gln Gly Val His Ser Gln Gly Gln Gly Pro Gly Ala Asn Phe Val Ser 
        35                  40                  45              


Phe Val Gly Gln Ala Gly Gly Gly Gly Pro Ala Gly Gln Gln Leu Pro 
    50                  55                  60                  


Gln Leu Pro Gln Ser Ser Gln Leu Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Gln Gln Gln Gln Pro Gln Pro Pro Gln Pro Pro Phe Pro Ala Gly Gly 
                85                  90                  95      


Pro Pro Ala Arg Arg Gly Gly Ala Gly Ala Gly Gly Gly Trp Lys Leu 
            100                 105                 110         


Ala Glu Glu Glu Ser Cys Arg Glu Asp Val Thr Arg Val Cys Pro Lys 
        115                 120                 125             


His Thr Trp Ser Asn Asn Leu Ala Val Leu Glu Cys Leu Gln Asp Val 
    130                 135                 140                 


Arg Glu Pro Glu Asn Glu Ile Ser Ser Asp Cys Asn His Leu Leu Trp 
145                 150                 155                 160 


Asn Tyr Lys Leu Asn Leu Thr Thr Asp Pro Lys Phe Glu Ser Val Ala 
                165                 170                 175     


Arg Glu Val Cys Lys Ser Thr Ile Thr Glu Ile Lys Glu Cys Ala Asp 
            180                 185                 190         


Glu Pro Val Gly Lys Gly Tyr Met Val Ser Cys Leu Val Asp His Arg 
        195                 200                 205             


Gly Asn Ile Thr Glu Tyr Gln Cys His Gln Tyr Ile Thr Lys Met Thr 
    210                 215                 220                 


Ala Ile Ile Phe Ser Asp Tyr Arg Leu Ile Cys Gly Phe Met Asp Asp 
225                 230                 235                 240 


Cys Lys Asn Asp Ile Asn Ile Leu Lys Cys Gly Ser Ile Arg Leu Gly 
                245                 250                 255     


Glu Lys Asp Ala His Ser Gln Gly Glu Val Val Ser Cys Leu Glu Lys 
            260                 265                 270         


Gly Leu Val Lys Glu Ala Glu Glu Arg Glu Pro Lys Ile Gln Val Ser 
        275                 280                 285             


Glu Leu Cys Lys Lys Ala Ile Leu Arg Val Ala Glu Leu Ser Ser Asp 
    290                 295                 300                 


Asp Phe His Leu Asp Arg His Leu Tyr Phe Ala Cys Arg Asp Asp Arg 
305                 310                 315                 320 


Glu Arg Phe Cys Glu Asn Thr Gln Ala Gly Glu Gly Arg Val Tyr Lys 
                325                 330                 335     


Cys Leu Phe Asn His Lys Phe Glu Glu Ser Met Ser Glu Lys Cys Arg 
            340                 345                 350         


Glu Ala Leu Thr Thr Arg Gln Lys Leu Ile Ala Gln Asp Tyr Lys Val 
        355                 360                 365             


Ser Tyr Ser Leu Ala Lys Ser Cys Lys Ser Asp Leu Lys Lys Tyr Arg 
    370                 375                 380                 


Cys Asn Val Glu Asn Leu Pro Arg Ser Arg Glu Ala Arg Leu Ser Tyr 
385                 390                 395                 400 


Leu Leu Met Cys Leu Glu Ser Ala Val His Arg Gly Arg Gln Val Ser 
                405                 410                 415     


Ser Glu Cys Gln Gly Glu Met Leu Asp Tyr Arg Arg Met Leu Met Glu 
            420                 425                 430         


Asp Phe Ser Leu Ser Pro Glu Ile Ile Leu Ser Cys Arg Gly Glu Ile 
        435                 440                 445             


Glu His His Cys Ser Gly Leu His Arg Lys Gly Arg Thr Leu His Cys 
    450                 455                 460                 


Leu Met Lys Val Val Arg Gly Glu Lys Gly Asn Leu Gly Met Asn Cys 
465                 470                 475                 480 


Gln Gln Ala Leu Gln Thr Leu Ile Gln Glu Thr Asp Pro Gly Ala Asp 
                485                 490                 495     


Tyr Arg Ile Asp Arg Ala Leu Asn Glu Ala Cys Glu Ser Val Ile Gln 
            500                 505                 510         


Thr Ala Cys Lys His Ile Arg Ser Gly Asp Pro Met Ile Leu Ser Cys 
        515                 520                 525             


Leu Met Glu His Leu Tyr Thr Glu Lys Met Val Glu Asp Cys Glu His 
    530                 535                 540                 


Arg Leu Leu Glu Leu Gln Tyr Phe Ile Ser Arg Asp Trp Lys Leu Asp 
545                 550                 555                 560 


Pro Val Leu Tyr Arg Lys Cys Gln Gly Asp Ala Ser Arg Leu Cys His 
                565                 570                 575     


Thr His Gly Trp Asn Glu Thr Ser Glu Phe Met Pro Gln Gly Ala Val 
            580                 585                 590         


Phe Ser Cys Leu Tyr Arg His Ala Tyr Arg Thr Glu Glu Gln Gly Arg 
        595                 600                 605             


Arg Leu Ser Arg Glu Cys Arg Ala Glu Val Gln Arg Ile Leu His Gln 
    610                 615                 620                 


Arg Ala Met Asp Val Lys Leu Asp Pro Ala Leu Gln Asp Lys Cys Leu 
625                 630                 635                 640 


Ile Asp Leu Gly Lys Trp Cys Ser Glu Lys Thr Glu Thr Gly Gln Glu 
                645                 650                 655     


Leu Glu Cys Leu Gln Asp His Leu Asp Asp Leu Val Val Glu Cys Arg 
            660                 665                 670         


Asp Ile Val Gly Asn Leu Thr Glu Leu Glu Ser Glu Asp Ile Gln Ile 
        675                 680                 685             


Glu Ala Leu Leu Met Arg Ala Cys Glu Pro Ile Ile Gln Asn Phe Cys 
    690                 695                 700                 


His Asp Val Ala Asp Asn Gln Ile Asp Ser Gly Asp Leu Met Glu Cys 
705                 710                 715                 720 


Leu Ile Gln Asn Lys His Gln Lys Asp Met Asn Glu Lys Cys Ala Ile 
                725                 730                 735     


Gly Val Thr His Phe Gln Leu Val Gln Met Lys Asp Phe Arg Phe Ser 
            740                 745                 750         


Tyr Lys Phe Lys Met Ala Cys Lys Glu Asp Val Leu Lys Leu Cys Pro 
        755                 760                 765             


Asn Ile Lys Lys Lys Val Asp Val Val Ile Cys Leu Ser Thr Thr Val 
    770                 775                 780                 


Arg Asn Asp Thr Leu Gln Glu Ala Lys Glu His Arg Val Ser Leu Lys 
785                 790                 795                 800 


Cys Arg Arg Gln Leu Arg Val Glu Glu Leu Glu Met Thr Glu Asp Ile 
                805                 810                 815     


Arg Leu Glu Pro Asp Leu Tyr Glu Ala Cys Lys Ser Asp Ile Lys Asn 
            820                 825                 830         


Phe Cys Ser Ala Val Gln Tyr Gly Asn Ala Gln Ile Ile Glu Cys Leu 
        835                 840                 845             


Lys Glu Asn Lys Lys Gln Leu Ser Thr Arg Cys His Gln Lys Val Phe 
    850                 855                 860                 


Lys Leu Gln Glu Thr Glu Met Met Asp Pro Glu Leu Asp Tyr Thr Leu 
865                 870                 875                 880 


Met Arg Val Cys Lys Gln Met Ile Lys Arg Phe Cys Pro Glu Ala Asp 
                885                 890                 895     


Ser Lys Thr Met Leu Gln Cys Leu Lys Gln Asn Lys Asn Ser Glu Leu 
            900                 905                 910         


Met Asp Pro Lys Cys Lys Gln Met Ile Thr Lys Arg Gln Ile Thr Gln 
        915                 920                 925             


Asn Thr Asp Tyr Arg Leu Asn Pro Met Leu Arg Lys Ala Cys Lys Ala 
    930                 935                 940                 


Asp Ile Pro Lys Phe Cys His Gly Ile Leu Thr Lys Ala Lys Asp Asp 
945                 950                 955                 960 


Ser Glu Leu Glu Gly Gln Val Ile Ser Cys Leu Lys Leu Arg Tyr Ala 
                965                 970                 975     


Asp Gln Arg Leu Ser Ser Asp Cys Glu Asp Gln Ile Arg Ile Ile Ile 
            980                 985                 990         


Gln Glu Ser Ala Leu Asp Tyr Arg  Leu Asp Pro Gln Leu  Gln Leu His 
        995                 1000                 1005             


Cys Ser  Asp Glu Ile Ser Ser  Leu Cys Ala Glu Glu  Ala Ala Ala 
    1010                 1015                 1020             


Gln Glu  Gln Thr Gly Gln Val  Glu Glu Cys Leu Lys  Val Asn Leu 
    1025                 1030                 1035             


Leu Lys  Ile Lys Thr Glu Leu  Cys Lys Lys Glu Val  Leu Asn Met 
    1040                 1045                 1050             


Leu Lys  Glu Ser Lys Ala Asp  Ile Phe Val Asp Pro  Val Leu His 
    1055                 1060                 1065             


Thr Ala  Cys Ala Leu Asp Ile  Lys His His Cys Ala  Ala Ile Thr 
    1070                 1075                 1080             


Pro Gly  Arg Gly Arg Gln Met  Ser Cys Leu Met Glu  Ala Leu Glu 
    1085                 1090                 1095             


Asp Lys  Arg Val Arg Leu Gln  Pro Glu Cys Lys Lys  Arg Leu Asn 
    1100                 1105                 1110             


Asp Arg  Ile Glu Met Trp Ser  Tyr Ala Ala Lys Val  Ala Pro Ala 
    1115                 1120                 1125             


Asp Gly  Phe Ser Asp Leu Ala  Met Gln Val Met Thr  Ser Pro Ser 
    1130                 1135                 1140             


Lys Asn  Tyr Ile Leu Ser Val  Ile Ser Gly Ser Ile  Cys Ile Leu 
    1145                 1150                 1155             


Phe Leu  Ile Gly Leu Met Cys  Gly Arg Ile Thr Lys  Arg Val Thr 
    1160                 1165                 1170             


Arg Glu  Leu Lys Asp Arg Leu  Gln Tyr Arg Ser Glu  Thr Met Ala 
    1175                 1180                 1185             


Tyr Lys  Gly Leu Val Trp Ser  Gln Asp Val Thr Gly  Ser Pro Ala 
    1190                 1195                 1200             


<210>  5999
<211>  1179
<212>  PRT
<213>  Homo Sapiens

<400>  5999

Met Ala Ala Cys Gly Arg Val Arg Arg Met Phe Arg Leu Ser Ala Ala 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Phe Ala Ala Gly Ala Glu Lys Leu Pro Gly 
            20                  25                  30          


Gln Gly Val His Ser Gln Gly Gln Gly Pro Gly Ala Asn Phe Val Ser 
        35                  40                  45              


Phe Val Gly Gln Ala Gly Gly Gly Gly Pro Ala Gly Gln Gln Leu Pro 
    50                  55                  60                  


Gln Leu Pro Gln Ser Ser Gln Leu Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Gln Gln Gln Gln Pro Gln Pro Pro Gln Pro Pro Phe Pro Ala Gly Gly 
                85                  90                  95      


Pro Pro Ala Arg Arg Gly Gly Ala Gly Ala Gly Gly Gly Trp Lys Leu 
            100                 105                 110         


Ala Glu Glu Glu Ser Cys Arg Glu Asp Val Thr Arg Val Cys Pro Lys 
        115                 120                 125             


His Thr Trp Ser Asn Asn Leu Ala Val Leu Glu Cys Leu Gln Asp Val 
    130                 135                 140                 


Arg Glu Pro Glu Asn Glu Ile Ser Ser Asp Cys Asn His Leu Leu Trp 
145                 150                 155                 160 


Asn Tyr Lys Leu Asn Leu Thr Thr Asp Pro Lys Phe Glu Ser Val Ala 
                165                 170                 175     


Arg Glu Val Cys Lys Ser Thr Ile Thr Glu Ile Lys Glu Cys Ala Asp 
            180                 185                 190         


Glu Pro Val Gly Lys Gly Tyr Met Val Ser Cys Leu Val Asp His Arg 
        195                 200                 205             


Gly Asn Ile Thr Glu Tyr Gln Cys His Gln Tyr Ile Thr Lys Met Thr 
    210                 215                 220                 


Ala Ile Ile Phe Ser Asp Tyr Arg Leu Ile Cys Gly Phe Met Asp Asp 
225                 230                 235                 240 


Cys Lys Asn Asp Ile Asn Ile Leu Lys Cys Gly Ser Ile Arg Leu Gly 
                245                 250                 255     


Glu Lys Asp Ala His Ser Gln Gly Glu Val Val Ser Cys Leu Glu Lys 
            260                 265                 270         


Gly Leu Val Lys Glu Ala Glu Glu Arg Glu Pro Lys Ile Gln Val Ser 
        275                 280                 285             


Glu Leu Cys Lys Lys Ala Ile Leu Arg Val Ala Glu Leu Ser Ser Asp 
    290                 295                 300                 


Asp Phe His Leu Asp Arg His Leu Tyr Phe Ala Cys Arg Asp Asp Arg 
305                 310                 315                 320 


Glu Arg Phe Cys Glu Asn Thr Gln Ala Gly Glu Gly Arg Val Tyr Lys 
                325                 330                 335     


Cys Leu Phe Asn His Lys Phe Glu Glu Ser Met Ser Glu Lys Cys Arg 
            340                 345                 350         


Glu Ala Leu Thr Thr Arg Gln Lys Leu Ile Ala Gln Asp Tyr Lys Val 
        355                 360                 365             


Ser Tyr Ser Leu Ala Lys Ser Cys Lys Ser Asp Leu Lys Lys Tyr Arg 
    370                 375                 380                 


Cys Asn Val Glu Asn Leu Pro Arg Ser Arg Glu Ala Arg Leu Ser Tyr 
385                 390                 395                 400 


Leu Leu Met Cys Leu Glu Ser Ala Val His Arg Gly Arg Gln Val Ser 
                405                 410                 415     


Ser Glu Cys Gln Gly Glu Met Leu Asp Tyr Arg Arg Met Leu Met Glu 
            420                 425                 430         


Asp Phe Ser Leu Ser Pro Glu Ile Ile Leu Ser Cys Arg Gly Glu Ile 
        435                 440                 445             


Glu His His Cys Ser Gly Leu His Arg Lys Gly Arg Thr Leu His Cys 
    450                 455                 460                 


Leu Met Lys Val Val Arg Gly Glu Lys Gly Asn Leu Gly Met Asn Cys 
465                 470                 475                 480 


Gln Gln Ala Leu Gln Thr Leu Ile Gln Glu Thr Asp Pro Gly Ala Asp 
                485                 490                 495     


Tyr Arg Ile Asp Arg Ala Leu Asn Glu Ala Cys Glu Ser Val Ile Gln 
            500                 505                 510         


Thr Ala Cys Lys His Ile Arg Ser Gly Asp Pro Met Ile Leu Ser Cys 
        515                 520                 525             


Leu Met Glu His Leu Tyr Thr Glu Lys Met Val Glu Asp Cys Glu His 
    530                 535                 540                 


Arg Leu Leu Glu Leu Gln Tyr Phe Ile Ser Arg Asp Trp Lys Leu Asp 
545                 550                 555                 560 


Pro Val Leu Tyr Arg Lys Cys Gln Gly Asp Ala Ser Arg Leu Cys His 
                565                 570                 575     


Thr His Gly Trp Asn Glu Thr Ser Glu Phe Met Pro Gln Gly Ala Val 
            580                 585                 590         


Phe Ser Cys Leu Tyr Arg His Ala Tyr Arg Thr Glu Glu Gln Gly Arg 
        595                 600                 605             


Arg Leu Ser Arg Glu Cys Arg Ala Glu Val Gln Arg Ile Leu His Gln 
    610                 615                 620                 


Arg Ala Met Asp Val Lys Leu Asp Pro Ala Leu Gln Asp Lys Cys Leu 
625                 630                 635                 640 


Ile Asp Leu Gly Lys Trp Cys Ser Glu Lys Thr Glu Thr Gly Gln Glu 
                645                 650                 655     


Leu Glu Cys Leu Gln Asp His Leu Asp Asp Leu Val Val Glu Cys Arg 
            660                 665                 670         


Asp Ile Val Gly Asn Leu Thr Glu Leu Glu Ser Glu Asp Ile Gln Ile 
        675                 680                 685             


Glu Ala Leu Leu Met Arg Ala Cys Glu Pro Ile Ile Gln Asn Phe Cys 
    690                 695                 700                 


His Asp Val Ala Asp Asn Gln Ile Asp Ser Gly Asp Leu Met Glu Cys 
705                 710                 715                 720 


Leu Ile Gln Asn Lys His Gln Lys Asp Met Asn Glu Lys Cys Ala Ile 
                725                 730                 735     


Gly Val Thr His Phe Gln Leu Val Gln Met Lys Asp Phe Arg Phe Ser 
            740                 745                 750         


Tyr Lys Phe Lys Met Ala Cys Lys Glu Asp Val Leu Lys Leu Cys Pro 
        755                 760                 765             


Asn Ile Lys Lys Lys Val Asp Val Val Ile Cys Leu Ser Thr Thr Val 
    770                 775                 780                 


Arg Asn Asp Thr Leu Gln Glu Ala Lys Glu His Arg Val Ser Leu Lys 
785                 790                 795                 800 


Cys Arg Arg Gln Leu Arg Val Glu Glu Leu Glu Met Thr Glu Asp Ile 
                805                 810                 815     


Arg Leu Glu Pro Asp Leu Tyr Glu Ala Cys Lys Ser Asp Ile Lys Asn 
            820                 825                 830         


Phe Cys Ser Ala Val Gln Tyr Gly Asn Ala Gln Ile Ile Glu Cys Leu 
        835                 840                 845             


Lys Glu Asn Lys Lys Gln Leu Ser Thr Arg Cys His Gln Lys Val Phe 
    850                 855                 860                 


Lys Leu Gln Glu Thr Glu Met Met Asp Pro Glu Leu Asp Tyr Thr Leu 
865                 870                 875                 880 


Met Arg Val Cys Lys Gln Met Ile Lys Arg Phe Cys Pro Glu Ala Asp 
                885                 890                 895     


Ser Lys Thr Met Leu Gln Cys Leu Lys Gln Asn Lys Asn Ser Glu Leu 
            900                 905                 910         


Met Asp Pro Lys Cys Lys Gln Met Ile Thr Lys Arg Gln Ile Thr Gln 
        915                 920                 925             


Asn Thr Asp Tyr Arg Leu Asn Pro Met Leu Arg Lys Ala Cys Lys Ala 
    930                 935                 940                 


Asp Ile Pro Lys Phe Cys His Gly Ile Leu Thr Lys Ala Lys Asp Asp 
945                 950                 955                 960 


Ser Glu Leu Glu Gly Gln Val Ile Ser Cys Leu Lys Leu Arg Tyr Ala 
                965                 970                 975     


Asp Gln Arg Leu Ser Ser Asp Cys Glu Asp Gln Ile Arg Ile Ile Ile 
            980                 985                 990         


Gln Glu Ser Ala Leu Asp Tyr Arg  Leu Asp Pro Gln Leu  Gln Leu His 
        995                 1000                 1005             


Cys Ser  Asp Glu Ile Ser Ser  Leu Cys Ala Glu Glu  Ala Ala Ala 
    1010                 1015                 1020             


Gln Glu  Gln Thr Gly Gln Val  Glu Glu Cys Leu Lys  Val Asn Leu 
    1025                 1030                 1035             


Leu Lys  Ile Lys Thr Glu Leu  Cys Lys Lys Glu Val  Leu Asn Met 
    1040                 1045                 1050             


Leu Lys  Glu Ser Lys Ala Asp  Ile Phe Val Asp Pro  Val Leu His 
    1055                 1060                 1065             


Thr Ala  Cys Ala Leu Asp Ile  Lys His His Cys Ala  Ala Ile Thr 
    1070                 1075                 1080             


Pro Gly  Arg Gly Arg Gln Met  Ser Cys Leu Met Glu  Ala Leu Glu 
    1085                 1090                 1095             


Asp Lys  Arg Val Arg Leu Gln  Pro Glu Cys Lys Lys  Arg Leu Asn 
    1100                 1105                 1110             


Asp Arg  Ile Glu Met Trp Ser  Tyr Ala Ala Lys Val  Ala Pro Ala 
    1115                 1120                 1125             


Asp Gly  Phe Ser Asp Leu Ala  Met Gln Val Met Thr  Ser Pro Ser 
    1130                 1135                 1140             


Lys Asn  Tyr Ile Leu Ser Val  Ile Ser Gly Ser Ile  Cys Ile Leu 
    1145                 1150                 1155             


Phe Leu  Ile Gly Leu Met Cys  Gly Arg Ile Thr Lys  Arg Val Thr 
    1160                 1165                 1170             


Arg Glu  Leu Lys Asp Arg 
    1175                 


<210>  6000
<211>  698
<212>  PRT
<213>  Homo Sapiens

<400>  6000

Met Ala Ala Cys Gly Arg Val Arg Arg Met Phe Arg Leu Ser Ala Ala 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Phe Ala Ala Gly Ala Glu Lys Leu Pro Gly 
            20                  25                  30          


Gln Gly Val His Ser Gln Gly Gln Gly Pro Gly Ala Asn Phe Val Ser 
        35                  40                  45              


Phe Val Gly Gln Ala Gly Gly Gly Gly Pro Ala Gly Gln Gln Leu Pro 
    50                  55                  60                  


Gln Leu Pro Gln Ser Ser Gln Leu Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Gln Gln Gln Gln Pro Gln Pro Pro Gln Pro Pro Phe Pro Ala Gly Gly 
                85                  90                  95      


Pro Pro Ala Arg Arg Gly Gly Ala Gly Ala Gly Gly Gly Trp Lys Leu 
            100                 105                 110         


Ala Glu Glu Glu Ser Cys Arg Glu Asp Val Thr Arg Val Cys Pro Lys 
        115                 120                 125             


His Thr Trp Ser Asn Asn Leu Ala Val Leu Glu Cys Leu Gln Asp Val 
    130                 135                 140                 


Arg Glu Pro Glu Asn Glu Ile Ser Ser Asp Cys Asn His Leu Leu Trp 
145                 150                 155                 160 


Asn Tyr Lys Leu Asn Leu Thr Thr Asp Pro Lys Phe Glu Ser Val Ala 
                165                 170                 175     


Arg Glu Val Cys Lys Ser Thr Ile Thr Glu Ile Lys Glu Cys Ala Asp 
            180                 185                 190         


Glu Pro Val Gly Lys Gly Tyr Met Val Ser Cys Leu Val Asp His Arg 
        195                 200                 205             


Gly Asn Ile Thr Glu Tyr Gln Cys His Gln Tyr Ile Thr Lys Met Thr 
    210                 215                 220                 


Ala Ile Ile Phe Ser Asp Tyr Arg Leu Ile Cys Gly Phe Met Asp Asp 
225                 230                 235                 240 


Cys Lys Asn Asp Ile Asn Ile Leu Lys Cys Gly Ser Ile Arg Leu Gly 
                245                 250                 255     


Glu Lys Asp Ala His Ser Gln Gly Glu Val Val Ser Cys Leu Glu Lys 
            260                 265                 270         


Gly Leu Val Lys Glu Ala Glu Glu Arg Glu Pro Lys Ile Gln Val Ser 
        275                 280                 285             


Glu Leu Cys Lys Lys Ala Ile Leu Arg Val Ala Glu Leu Ser Ser Asp 
    290                 295                 300                 


Asp Phe His Leu Asp Arg His Leu Tyr Phe Ala Cys Arg Asp Asp Arg 
305                 310                 315                 320 


Glu Arg Phe Cys Glu Asn Thr Gln Ala Gly Glu Gly Arg Val Tyr Lys 
                325                 330                 335     


Cys Leu Phe Asn His Lys Phe Glu Glu Ser Met Ser Glu Lys Cys Arg 
            340                 345                 350         


Glu Ala Leu Thr Thr Arg Gln Lys Leu Ile Ala Gln Asp Tyr Lys Val 
        355                 360                 365             


Ser Tyr Ser Leu Ala Lys Ser Cys Lys Ser Asp Leu Lys Lys Tyr Arg 
    370                 375                 380                 


Cys Asn Val Glu Asn Leu Pro Arg Ser Arg Glu Ala Arg Leu Ser Tyr 
385                 390                 395                 400 


Leu Leu Met Cys Leu Glu Ser Ala Val His Arg Gly Arg Gln Val Ser 
                405                 410                 415     


Ser Glu Cys Gln Gly Glu Met Leu Asp Tyr Arg Arg Met Leu Met Glu 
            420                 425                 430         


Asp Phe Ser Leu Ser Pro Glu Ile Ile Leu Ser Cys Arg Gly Glu Ile 
        435                 440                 445             


Glu His His Cys Ser Gly Leu His Arg Lys Gly Arg Thr Leu His Cys 
    450                 455                 460                 


Leu Met Lys Val Val Arg Gly Glu Lys Gly Asn Leu Gly Met Asn Cys 
465                 470                 475                 480 


Gln Gln Ala Leu Gln Thr Leu Ile Gln Glu Thr Asp Pro Gly Ala Asp 
                485                 490                 495     


Tyr Arg Ile Asp Arg Ala Leu Asn Glu Ala Cys Glu Ser Val Ile Gln 
            500                 505                 510         


Thr Ala Cys Lys His Ile Arg Ser Gly Asp Pro Met Ile Leu Ser Cys 
        515                 520                 525             


Leu Met Glu His Leu Tyr Thr Glu Lys Met Val Glu Asp Cys Glu His 
    530                 535                 540                 


Arg Leu Leu Glu Leu Gln Tyr Phe Ile Ser Arg Asp Trp Lys Leu Asp 
545                 550                 555                 560 


Pro Val Leu Tyr Arg Lys Cys Gln Gly Asp Ala Ser Arg Leu Cys His 
                565                 570                 575     


Thr His Gly Trp Asn Glu Thr Ser Glu Phe Met Pro Gln Gly Ala Val 
            580                 585                 590         


Phe Ser Cys Leu Tyr Arg His Ala Tyr Arg Thr Glu Glu Gln Gly Arg 
        595                 600                 605             


Arg Leu Ser Arg Glu Cys Arg Ala Glu Val Gln Arg Ile Leu His Gln 
    610                 615                 620                 


Arg Ala Met Asp Val Lys Leu Asp Pro Ala Leu Gln Asp Lys Cys Leu 
625                 630                 635                 640 


Ile Asp Leu Gly Lys Trp Cys Ser Glu Lys Thr Glu Thr Gly Gln Glu 
                645                 650                 655     


Leu Glu Cys Leu Gln Asp His Leu Asp Asp Leu Val Val Glu Cys Arg 
            660                 665                 670         


Asp Ile Val Gly Asn Leu Thr Glu Leu Glu Ser Glu Ala Glu Arg Glu 
        675                 680                 685             


Tyr Val Phe Lys Asn Leu Pro Phe Lys Val 
    690                 695             


<210>  6001
<211>  305
<212>  PRT
<213>  Homo Sapiens

<400>  6001

Met Ala Ala Cys Gly Arg Val Arg Arg Met Phe Arg Leu Ser Ala Ala 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Phe Ala Ala Gly Ala Glu Lys Leu Pro Gly 
            20                  25                  30          


Gln Gly Val His Ser Gln Gly Gln Gly Pro Gly Ala Asn Phe Val Ser 
        35                  40                  45              


Phe Val Gly Gln Ala Gly Gly Gly Gly Pro Ala Gly Gln Gln Leu Pro 
    50                  55                  60                  


Gln Leu Pro Gln Ser Ser Gln Leu Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Gln Gln Gln Gln Pro Gln Pro Pro Gln Pro Pro Phe Pro Ala Gly Gly 
                85                  90                  95      


Pro Pro Ala Arg Arg Gly Gly Ala Gly Ala Gly Gly Gly Trp Lys Leu 
            100                 105                 110         


Ala Glu Glu Glu Ser Cys Arg Glu Asp Val Thr Arg Val Cys Pro Lys 
        115                 120                 125             


His Thr Trp Ser Asn Asn Leu Ala Val Leu Glu Cys Leu Gln Asp Val 
    130                 135                 140                 


Arg Glu Pro Glu Asn Glu Ile Ser Ser Asp Cys Asn His Leu Leu Trp 
145                 150                 155                 160 


Asn Tyr Lys Leu Asn Leu Thr Thr Asp Pro Lys Phe Glu Ser Val Ala 
                165                 170                 175     


Arg Glu Val Cys Lys Ser Thr Ile Thr Glu Ile Lys Glu Cys Ala Asp 
            180                 185                 190         


Glu Pro Val Gly Lys Gly Tyr Met Val Ser Cys Leu Val Asp His Arg 
        195                 200                 205             


Gly Asn Ile Thr Glu Tyr Gln Cys His Gln Tyr Ile Thr Lys Met Thr 
    210                 215                 220                 


Ala Ile Ile Phe Ser Asp Tyr Arg Leu Ile Cys Gly Phe Met Asp Asp 
225                 230                 235                 240 


Cys Lys Asn Asp Ile Asn Ile Leu Lys Cys Gly Ser Ile Arg Leu Gly 
                245                 250                 255     


Glu Lys Asp Ala His Ser Gln Asp Thr Pro Thr Ala Leu Arg Asn Arg 
            260                 265                 270         


Glu Gly Gly Ser His Gly Ser Ala Glu Leu Lys Ser Lys Gly Ser Tyr 
        275                 280                 285             


Thr Ser Val Pro Trp Met Ser Ser Trp Ile Leu Pro Ser Arg Ile Ser 
    290                 295                 300                 


Ala 
305 


<210>  6002
<211>  698
<212>  PRT
<213>  Homo Sapiens

<400>  6002

Met Ala Ala Cys Gly Arg Val Arg Arg Met Phe Arg Leu Ser Ala Ala 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Phe Ala Ala Gly Ala Glu Lys Leu Pro Gly 
            20                  25                  30          


Gln Gly Val His Ser Gln Gly Gln Gly Pro Gly Ala Asn Phe Val Ser 
        35                  40                  45              


Phe Val Gly Gln Ala Gly Gly Gly Gly Pro Ala Gly Gln Gln Leu Pro 
    50                  55                  60                  


Gln Leu Pro Gln Ser Ser Gln Leu Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Gln Gln Gln Gln Pro Gln Pro Pro Gln Pro Pro Phe Pro Ala Gly Gly 
                85                  90                  95      


Pro Pro Ala Arg Arg Gly Gly Ala Gly Ala Gly Gly Gly Trp Lys Leu 
            100                 105                 110         


Ala Glu Glu Glu Ser Cys Arg Glu Asp Val Thr Arg Val Cys Pro Lys 
        115                 120                 125             


His Thr Trp Ser Asn Asn Leu Ala Val Leu Glu Cys Leu Gln Asp Val 
    130                 135                 140                 


Arg Glu Pro Glu Asn Glu Ile Ser Ser Asp Cys Asn His Leu Leu Trp 
145                 150                 155                 160 


Asn Tyr Lys Leu Asn Leu Thr Thr Asp Pro Lys Phe Glu Ser Val Ala 
                165                 170                 175     


Arg Glu Val Cys Lys Ser Thr Ile Thr Glu Ile Lys Glu Cys Ala Asp 
            180                 185                 190         


Glu Pro Val Gly Lys Gly Tyr Met Val Ser Cys Leu Val Asp His Arg 
        195                 200                 205             


Gly Asn Ile Thr Glu Tyr Gln Cys His Gln Tyr Ile Thr Lys Met Thr 
    210                 215                 220                 


Ala Ile Ile Phe Ser Asp Tyr Arg Leu Ile Cys Gly Phe Met Asp Asp 
225                 230                 235                 240 


Cys Lys Asn Asp Ile Asn Ile Leu Lys Cys Gly Ser Ile Arg Leu Gly 
                245                 250                 255     


Glu Lys Asp Ala His Ser Gln Gly Glu Val Val Ser Cys Leu Glu Lys 
            260                 265                 270         


Gly Leu Val Lys Glu Ala Glu Glu Arg Glu Pro Lys Ile Gln Val Ser 
        275                 280                 285             


Glu Leu Cys Lys Lys Ala Ile Leu Arg Val Ala Glu Leu Ser Ser Asp 
    290                 295                 300                 


Asp Phe His Leu Asp Arg His Leu Tyr Phe Ala Cys Arg Asp Asp Arg 
305                 310                 315                 320 


Glu Arg Phe Cys Glu Asn Thr Gln Ala Gly Glu Gly Arg Val Tyr Lys 
                325                 330                 335     


Cys Leu Phe Asn His Lys Phe Glu Glu Ser Met Ser Glu Lys Cys Arg 
            340                 345                 350         


Glu Ala Leu Thr Thr Arg Gln Lys Leu Ile Ala Gln Asp Tyr Lys Val 
        355                 360                 365             


Ser Tyr Ser Leu Ala Lys Ser Cys Lys Ser Asp Leu Lys Lys Tyr Arg 
    370                 375                 380                 


Cys Asn Val Glu Asn Leu Pro Arg Ser Arg Glu Ala Arg Leu Ser Tyr 
385                 390                 395                 400 


Leu Leu Met Cys Leu Glu Ser Ala Val His Arg Gly Arg Gln Val Ser 
                405                 410                 415     


Ser Glu Cys Gln Gly Glu Met Leu Asp Tyr Arg Arg Met Leu Met Glu 
            420                 425                 430         


Asp Phe Ser Leu Ser Pro Glu Ile Ile Leu Ser Cys Arg Gly Glu Ile 
        435                 440                 445             


Glu His His Cys Ser Gly Leu His Arg Lys Gly Arg Thr Leu His Cys 
    450                 455                 460                 


Leu Met Lys Val Val Arg Gly Glu Lys Gly Asn Leu Gly Met Asn Cys 
465                 470                 475                 480 


Gln Gln Ala Leu Gln Thr Leu Ile Gln Glu Thr Asp Pro Gly Ala Asp 
                485                 490                 495     


Tyr Arg Ile Asp Arg Ala Leu Asn Glu Ala Cys Glu Ser Val Ile Gln 
            500                 505                 510         


Thr Ala Cys Lys His Ile Arg Ser Gly Asp Pro Met Ile Leu Ser Cys 
        515                 520                 525             


Leu Met Glu His Leu Tyr Thr Glu Lys Met Val Glu Asp Cys Glu His 
    530                 535                 540                 


Arg Leu Leu Glu Leu Gln Tyr Phe Ile Ser Arg Asp Trp Lys Leu Asp 
545                 550                 555                 560 


Pro Val Leu Tyr Arg Lys Cys Gln Gly Asp Ala Ser Arg Leu Cys His 
                565                 570                 575     


Thr His Gly Trp Asn Glu Thr Ser Glu Phe Met Pro Gln Gly Ala Val 
            580                 585                 590         


Phe Ser Cys Leu Tyr Arg His Ala Tyr Arg Thr Glu Glu Gln Gly Arg 
        595                 600                 605             


Arg Leu Ser Arg Glu Cys Arg Ala Glu Val Gln Arg Ile Leu His Gln 
    610                 615                 620                 


Arg Ala Met Asp Val Lys Leu Asp Pro Ala Leu Gln Asp Lys Cys Leu 
625                 630                 635                 640 


Ile Asp Leu Gly Lys Trp Cys Ser Glu Lys Thr Glu Thr Gly Gln Glu 
                645                 650                 655     


Leu Glu Cys Leu Gln Asp His Leu Asp Asp Leu Val Val Glu Cys Arg 
            660                 665                 670         


Asp Ile Val Gly Asn Leu Thr Glu Leu Glu Ser Glu Ala Glu Arg Glu 
        675                 680                 685             


Tyr Val Phe Lys Asn Leu Pro Phe Lys Val 
    690                 695             


<210>  6003
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  6003

Met Ala Ala Cys Gly Arg Val Arg Arg Met Phe Arg Leu Ser Ala Ala 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Phe Ala Ala Gly Ala Glu Lys Leu Pro Gly 
            20                  25                  30          


Gln Gly Val His Ser Gln Gly Gln Gly Pro Gly Ala Asn Phe Val Ser 
        35                  40                  45              


Phe Val Gly Gln Pro Pro Phe Pro Ala Gly Gly Pro Pro Ala Arg Arg 
    50                  55                  60                  


Gly Gly Ala Gly Ala Gly Gly Gly Trp Lys Leu Ala Glu Glu Glu Ser 
65                  70                  75                  80  


Cys Arg Glu Asp Val Thr Arg Val Cys Pro Lys His Thr Trp Ser Asn 
                85                  90                  95      


Asn Leu Ala Val Leu Glu Cys Leu Gln Asp Val Arg Glu Pro Glu Asn 
            100                 105                 110         


Glu Ile Ser Ser Asp Cys Asn His Leu Leu Trp Asn Tyr Lys Leu Asn 
        115                 120                 125             


Leu Thr Thr Asp Pro Lys Phe Glu Ser Val Ala Arg Glu Val Cys Lys 
    130                 135                 140                 


Ser Thr Ile Thr Glu Ile Lys Glu 
145                 150         


<210>  6004
<211>  74
<212>  PRT
<213>  Homo Sapiens

<400>  6004

Met Val Ser Cys Leu Val Asp His Arg Gly Asn Ile Thr Glu Tyr Gln 
1               5                   10                  15      


Cys His Gln Tyr Ile Thr Lys Met Thr Ala Ile Ile Phe Ser Asp Tyr 
            20                  25                  30          


Arg Leu Ile Cys Gly Phe Met Asp Asp Cys Lys Asn Asp Ile Asn Ile 
        35                  40                  45              


Leu Lys Cys Gly Ser Ile Arg Leu Gly Glu Lys Asp Ala His Ser Gln 
    50                  55                  60                  


Gly Glu Val Val Ser Cys Leu Glu Lys Gly 
65                  70                  


<210>  6005
<211>  148
<212>  PRT
<213>  Homo Sapiens

<400>  6005

Met Arg Val Thr Leu Ala Thr Ile Ala Trp Met Val Ser Phe Val Ser 
1               5                   10                  15      


Asn Tyr Ser His Thr Ala Asn Ile Leu Pro Asp Ile Glu Asn Glu Asp 
            20                  25                  30          


Phe Ile Lys Asp Cys Val Arg Ile His Asn Lys Phe Arg Ser Glu Val 
        35                  40                  45              


Lys Pro Thr Ala Ser Asp Met Leu Tyr Met Thr Trp Asp Pro Ala Leu 
    50                  55                  60                  


Ala Gln Ile Ala Lys Ala Trp Ala Ser Asn Cys Gln Phe Ser His Asn 
65                  70                  75                  80  


Thr Arg Leu Lys Pro Pro His Lys Leu His Pro Asn Phe Thr Ser Leu 
                85                  90                  95      


Gly Glu Asn Ile Trp Thr Gly Ser Val Pro Ile Phe Ser Val Ser Ser 
            100                 105                 110         


Ala Ile Thr Asn Trp Tyr Asp Glu Ile Gln Asp Tyr Asp Phe Lys Thr 
        115                 120                 125             


Arg Ile Cys Lys Lys Val Cys Gly His Tyr Thr Gln Arg Glu Leu Pro 
    130                 135                 140                 


Asn Leu Ala Ile 
145             


<210>  6006
<211>  238
<212>  PRT
<213>  Homo Sapiens

<400>  6006

Met Arg Val Thr Leu Ala Thr Ile Ala Trp Met Val Ser Phe Val Ser 
1               5                   10                  15      


Asn Tyr Ser His Thr Ala Asn Ile Leu Pro Asp Ile Glu Asn Glu Asp 
            20                  25                  30          


Phe Ile Lys Asp Cys Val Arg Ile His Asn Lys Phe Arg Ser Glu Val 
        35                  40                  45              


Lys Pro Thr Ala Ser Asp Met Leu Tyr Met Thr Trp Asp Pro Ala Leu 
    50                  55                  60                  


Ala Gln Ile Ala Lys Ala Trp Ala Ser Asn Cys Gln Phe Ser His Asn 
65                  70                  75                  80  


Thr Arg Leu Lys Pro Pro His Lys Leu His Pro Asn Phe Thr Ser Leu 
                85                  90                  95      


Gly Glu Asn Ile Trp Thr Gly Ser Val Pro Ile Phe Ser Val Ser Ser 
            100                 105                 110         


Ala Ile Thr Asn Trp Tyr Asp Glu Ile Gln Asp Tyr Asp Phe Lys Thr 
        115                 120                 125             


Arg Ile Cys Lys Lys Val Cys Gly His Tyr Thr Gln Val Ser Gln Glu 
    130                 135                 140                 


Arg Gly Arg Asp Pro Asn Pro Lys Arg Gly Phe Leu Asn Leu Ala Arg 
145                 150                 155                 160 


Glu Asn Pro Gly Leu Phe Gly Gln Ile Val Thr Lys Leu Ala Ala Gln 
                165                 170                 175     


Phe Asn Phe Ala Leu Lys Phe Leu Ala Leu Thr Leu Phe Pro Met Glu 
            180                 185                 190         


His Ile Leu Tyr Ala Thr Thr Asp Gln Glu Gly Ile Thr Gln Leu Gly 
        195                 200                 205             


His Ile Arg Glu Glu Pro Pro Ala Val Pro Ala Pro Ile Met Thr Ser 
    210                 215                 220                 


Val Trp Thr Ile Ser Val Leu Thr Asp Ser Glu Thr Lys Ser 
225                 230                 235             


<210>  6007
<211>  266
<212>  PRT
<213>  Homo Sapiens

<400>  6007

Met Arg Val Thr Leu Ala Thr Ile Ala Trp Met Val Ser Phe Val Ser 
1               5                   10                  15      


Asn Tyr Ser His Thr Ala Asn Ile Leu Pro Asp Ile Glu Asn Glu Asp 
            20                  25                  30          


Phe Ile Lys Asp Cys Val Arg Ile His Asn Lys Phe Arg Ser Glu Val 
        35                  40                  45              


Lys Pro Thr Ala Ser Asp Met Leu Tyr Met Thr Trp Asp Pro Ala Leu 
    50                  55                  60                  


Ala Gln Ile Ala Lys Ala Trp Ala Ser Asn Cys Gln Phe Ser His Asn 
65                  70                  75                  80  


Thr Arg Leu Lys Pro Pro His Lys Leu His Pro Asn Phe Thr Ser Leu 
                85                  90                  95      


Gly Glu Asn Ile Trp Thr Gly Ser Val Pro Ile Phe Ser Val Ser Ser 
            100                 105                 110         


Ala Ile Thr Asn Trp Tyr Asp Glu Ile Gln Asp Tyr Asp Phe Lys Thr 
        115                 120                 125             


Arg Ile Cys Lys Lys Val Cys Gly His Tyr Thr Gln Val Val Trp Ala 
    130                 135                 140                 


Asp Ser Tyr Lys Val Gly Cys Ala Val Gln Phe Cys Pro Lys Val Ser 
145                 150                 155                 160 


Gly Phe Asp Ala Leu Ser Asn Gly Ala His Phe Ile Cys Asn Tyr Gly 
                165                 170                 175     


Pro Gly Gly Asn Tyr Pro Thr Trp Pro Tyr Lys Arg Gly Ala Thr Cys 
            180                 185                 190         


Ser Ala Cys Pro Asn Asn Asp Lys Cys Leu Asp Asn Leu Cys Val Asn 
        195                 200                 205             


Arg Gln Arg Asp Gln Val Lys Arg Tyr Tyr Ser Val Val Tyr Pro Gly 
    210                 215                 220                 


Trp Pro Ile Tyr Pro Arg Asn Arg Tyr Thr Ser Leu Phe Leu Ile Val 
225                 230                 235                 240 


Asn Ser Val Ile Leu Ile Leu Ser Val Ile Ile Thr Ile Leu Val Gln 
                245                 250                 255     


His Lys Tyr Pro Asn Leu Val Leu Leu Asp 
            260                 265     


<210>  6008
<211>  89
<212>  PRT
<213>  Homo Sapiens

<400>  6008

Met Thr Lys Ser Arg Thr Met Thr Ser Arg Leu Gly Tyr Ala Lys Lys 
1               5                   10                  15      


Ser Val Ala Thr Thr Leu Arg Leu Phe Gly Gln Ile Val Thr Lys Leu 
            20                  25                  30          


Ala Ala Gln Phe Asn Phe Ala Leu Lys Phe Leu Ala Leu Thr Leu Phe 
        35                  40                  45              


Pro Met Glu His Ile Leu Tyr Ala Thr Thr Asp Gln Glu Gly Ile Thr 
    50                  55                  60                  


Gln Leu Gly His Ile Arg Glu Glu Pro Pro Ala Val Pro Ala Pro Ile 
65                  70                  75                  80  


Met Thr Ser Val Trp Thr Ile Ser Val 
                85                  


<210>  6009
<211>  233
<212>  PRT
<213>  Homo Sapiens

<400>  6009

Met Ala Leu Lys Asn Lys Phe Ser Cys Leu Trp Ile Leu Gly Leu Cys 
1               5                   10                  15      


Leu Val Ala Thr Thr Ser Ser Lys Ile Pro Ser Ile Thr Asp Pro His 
            20                  25                  30          


Phe Ile Asp Asn Cys Ile Glu Ala His Asn Glu Trp Arg Gly Lys Val 
        35                  40                  45              


Asn Pro Pro Ala Ala Asp Met Lys Tyr Met Ile Trp Asp Lys Gly Leu 
    50                  55                  60                  


Ala Lys Met Ala Lys Ala Trp Ala Asn Gln Cys Lys Phe Glu His Asn 
65                  70                  75                  80  


Asp Cys Leu Asp Lys Ser Tyr Lys Cys Tyr Ala Ala Phe Glu Tyr Val 
                85                  90                  95      


Gly Glu Asn Ile Trp Leu Gly Gly Ile Lys Ser Phe Thr Pro Arg His 
            100                 105                 110         


Ala Ile Thr Ala Trp Tyr Asn Glu Thr Gln Phe Tyr Asp Phe Asp Ser 
        115                 120                 125             


Leu Ser Cys Ser Arg Val Cys Gly His Tyr Thr Gln Leu Val Trp Ala 
    130                 135                 140                 


Asn Ser Phe Tyr Val Gly Cys Ala Val Ala Met Cys Pro Asn Leu Gly 
145                 150                 155                 160 


Gly Ala Ser Thr Ala Ile Phe Val Cys Asn Tyr Gly Pro Ala Gly Asn 
                165                 170                 175     


Phe Ala Asn Met Pro Pro Tyr Val Arg Gly Glu Ser Cys Ser Leu Cys 
            180                 185                 190         


Ser Lys Glu Glu Lys Cys Val Lys Asn Leu Cys Lys Asn Pro Phe Leu 
        195                 200                 205             


Lys Pro Thr Gly Arg Ala Pro Gln Gln Thr Ala Phe Asn Pro Phe Ser 
    210                 215                 220                 


Leu Gly Phe Leu Leu Leu Arg Ile Phe 
225                 230             


<210>  6010
<211>  242
<212>  PRT
<213>  Homo Sapiens

<400>  6010

Met Ala Leu Lys Asn Lys Phe Ser Cys Leu Trp Ile Leu Gly Leu Cys 
1               5                   10                  15      


Leu Val Ala Thr Thr Ser Ser Lys Ile Pro Ser Ile Thr Asp Pro His 
            20                  25                  30          


Phe Ile Asp Asn Cys Ile Glu Ala His Asn Glu Trp Arg Gly Lys Val 
        35                  40                  45              


Asn Pro Pro Ala Ala Asp Met Lys Tyr Met Ile Trp Asp Lys Gly Leu 
    50                  55                  60                  


Ala Lys Met Ala Lys Ala Trp Ala Asn Gln Cys Lys Phe Glu His Asn 
65                  70                  75                  80  


Asp Cys Leu Asp Lys Ser Tyr Lys Cys Tyr Ala Ala Phe Glu Tyr Val 
                85                  90                  95      


Gly Glu Asn Ile Trp Leu Gly Gly Ile Lys Ser Phe Thr Pro Arg His 
            100                 105                 110         


Ala Ile Thr Ala Trp Tyr Asn Glu Thr Gln Phe Tyr Asp Phe Asp Ser 
        115                 120                 125             


Leu Ser Cys Ser Arg Val Cys Gly His Tyr Thr Gln Leu Val Trp Ala 
    130                 135                 140                 


Asn Ser Phe Tyr Val Gly Cys Ala Val Ala Met Cys Pro Asn Leu Gly 
145                 150                 155                 160 


Gly Ala Ser Thr Ala Ile Phe Val Cys Asn Tyr Gly Pro Ala Gly Asn 
                165                 170                 175     


Phe Ala Asn Met Pro Pro Tyr Val Arg Gly Glu Ser Cys Ser Leu Cys 
            180                 185                 190         


Ser Lys Glu Glu Lys Cys Val Lys Asn Leu Cys Arg Thr Pro Gln Leu 
        195                 200                 205             


Ile Ile Pro Asn Gln Asn Pro Phe Leu Lys Pro Thr Gly Arg Ala Pro 
    210                 215                 220                 


Gln Gln Thr Ala Phe Asn Pro Phe Ser Leu Gly Phe Leu Leu Leu Arg 
225                 230                 235                 240 


Ile Phe 
        


<210>  6011
<211>  57
<212>  PRT
<213>  Homo Sapiens

<400>  6011

Met Ser Leu Leu Lys Leu Ile Leu Leu Arg Val Pro Cys Arg Ala Thr 
1               5                   10                  15      


Ala Cys Gln Lys Gly Leu Thr Thr Gln Thr Phe Pro Leu Ser Pro Gln 
            20                  25                  30          


Ser Pro Lys Gly Gln Leu Ala Ala Cys Ser Asn Lys Met Ser Phe Leu 
        35                  40                  45              


Phe Arg Ala Glu Glu Lys Ile His Phe 
    50                  55          


<210>  6012
<211>  39
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6012

Xaa Leu Ser Pro Gln Ser Pro Lys Gly Gln Leu Ala Ala Cys Ser Asn 
1               5                   10                  15      


Lys Met Ser Phe Leu Phe Arg Ala Glu Glu Gly Leu His Asn Leu Leu 
            20                  25                  30          


Tyr Leu Thr Lys Ile His Phe 
        35                  


<210>  6013
<211>  56
<212>  PRT
<213>  Homo Sapiens

<400>  6013

Met Met Val Gln Arg Leu Gly Leu Ile Ser Pro Pro Ala Ser Gln Val 
1               5                   10                  15      


Ser Thr Ala Cys Asn Gln Ile Ser Pro Ser Leu Gln Arg Ala Met Asn 
            20                  25                  30          


Ala Ala Asn Leu Asn Ile Pro Pro Ser Asp Thr Arg Lys Cys Gly Lys 
        35                  40                  45              


His Gly Lys Val Pro Ser Thr Lys 
    50                  55      


<210>  6014
<211>  89
<212>  PRT
<213>  Homo Sapiens

<400>  6014

Met Met Val Gln Arg Leu Gly Leu Ile Ser Pro Pro Ala Ser Gln Val 
1               5                   10                  15      


Ser Thr Ala Cys Asn Gln Ile Ser Pro Ser Leu Gln Arg Ala Met Asn 
            20                  25                  30          


Ala Ala Asn Leu Asn Ile Pro Pro Ser Asp Thr Arg Ser Leu Ile Ser 
        35                  40                  45              


Arg Glu Ser Leu Ala Ser Thr Thr Leu Ser Leu Thr Glu Ser Gln Ser 
    50                  55                  60                  


Ala Ser Ser Met Lys Gln Glu Trp Ser Gln Gly Tyr Arg Ala Leu Pro 
65                  70                  75                  80  


Ser Leu Ser Asn His Gly Ser Gln Asn 
                85                  


<210>  6015
<211>  89
<212>  PRT
<213>  Homo Sapiens

<400>  6015

Met Met Val Gln Arg Leu Gly Leu Ile Ser Pro Pro Ala Ser Gln Val 
1               5                   10                  15      


Ser Thr Ala Cys Asn Gln Ile Ser Pro Ser Leu Gln Arg Ala Met Asn 
            20                  25                  30          


Ala Ala Asn Leu Asn Ile Pro Pro Ser Asp Thr Arg Ser Leu Ile Ser 
        35                  40                  45              


Arg Glu Ser Leu Ala Ser Thr Thr Leu Ser Leu Thr Glu Ser Gln Ser 
    50                  55                  60                  


Ala Ser Ser Met Lys Gln Glu Trp Ser Gln Gly Tyr Arg Ala Leu Pro 
65                  70                  75                  80  


Ser Leu Ser Asn His Gly Ser Gln Asn 
                85                  


<210>  6016
<211>  89
<212>  PRT
<213>  Homo Sapiens

<400>  6016

Met Met Val Gln Arg Leu Gly Leu Ile Ser Pro Pro Ala Ser Gln Val 
1               5                   10                  15      


Ser Thr Ala Cys Asn Gln Ile Ser Pro Ser Leu Gln Arg Ala Met Asn 
            20                  25                  30          


Ala Ala Asn Leu Asn Ile Pro Pro Ser Asp Thr Arg Ser Leu Ile Ser 
        35                  40                  45              


Arg Glu Ser Leu Ala Ser Thr Thr Leu Ser Leu Thr Glu Ser Gln Ser 
    50                  55                  60                  


Ala Ser Ser Met Lys Gln Glu Trp Ser Gln Gly Tyr Arg Ala Leu Pro 
65                  70                  75                  80  


Ser Leu Ser Asn His Gly Ser Gln Asn 
                85                  


<210>  6017
<211>  775
<212>  PRT
<213>  Homo Sapiens

<400>  6017

Met Met Val Gln Arg Leu Gly Leu Ile Ser Pro Pro Ala Ser Gln Val 
1               5                   10                  15      


Ser Thr Ala Cys Asn Gln Ile Ser Pro Ser Leu Gln Arg Ala Met Asn 
            20                  25                  30          


Ala Ala Asn Leu Asn Ile Pro Pro Ser Asp Thr Arg Ser Leu Ile Ser 
        35                  40                  45              


Arg Glu Ser Leu Ala Ser Thr Thr Leu Ser Leu Thr Glu Ser Gln Ser 
    50                  55                  60                  


Ala Ser Ser Met Lys Gln Glu Trp Ser Gln Gly Tyr Arg Ala Leu Pro 
65                  70                  75                  80  


Ser Leu Ser Asn His Gly Ser Gln Asn Gly Leu Asp Leu Gly Asp Leu 
                85                  90                  95      


Leu Ser Leu Pro Pro Gly Thr Ser Met Ser Ser Asn Ser Val Ser Asn 
            100                 105                 110         


Ser Leu Pro Ser Tyr Leu Phe Gly Thr Glu Ser Ser His Ser Pro Tyr 
        115                 120                 125             


Pro Ser Pro Arg His Ser Ser Thr Arg Ser His Ser Ala Arg Ser Lys 
    130                 135                 140                 


Lys Arg Ala Leu Ser Leu Ser Pro Leu Ser Asp Gly Ile Gly Ile Asp 
145                 150                 155                 160 


Phe Asn Thr Ile Ile Arg Thr Ser Pro Thr Ser Leu Val Ala Tyr Ile 
                165                 170                 175     


Asn Gly Ser Arg Ala Ser Pro Ala Asn Leu Ser Pro Gln Pro Glu Val 
            180                 185                 190         


Tyr Gly His Phe Leu Gly Val Arg Gly Ser Cys Ile Pro Gln Pro Arg 
        195                 200                 205             


Pro Val Pro Gly Ser Gln Lys Gly Val Leu Val Ala Pro Gly Gly Leu 
    210                 215                 220                 


Ala Leu Pro Ala Tyr Gly Glu Asp Gly Ala Leu Glu His Glu Arg Met 
225                 230                 235                 240 


Gln Gln Leu Glu His Gly Gly Leu Gln Pro Gly Leu Val Asn His Met 
                245                 250                 255     


Val Val Gln His Gly Leu Pro Gly Pro Asp Ser Gln Ser Ala Gly Leu 
            260                 265                 270         


Phe Lys Thr Glu Arg Leu Glu Glu Phe Pro Gly Ser Thr Val Asp Leu 
        275                 280                 285             


Pro Pro Ala Pro Pro Leu Pro Pro Leu Pro Pro Pro Pro Gly Pro Pro 
    290                 295                 300                 


Pro Pro Tyr His Ala His Ala His Leu His His Pro Glu Leu Gly Pro 
305                 310                 315                 320 


His Ala Gln Gln Leu Ala Leu Pro Gln Ala Thr Leu Asp Asp Asp Gly 
                325                 330                 335     


Glu Met Asp Gly Ile Gly Gly Lys His Cys Cys Arg Trp Ile Asp Cys 
            340                 345                 350         


Ser Ala Leu Tyr Asp Gln Gln Glu Glu Leu Val Arg His Ile Glu Lys 
        355                 360                 365             


Val His Ile Asp Gln Arg Lys Gly Glu Asp Phe Thr Cys Phe Trp Ala 
    370                 375                 380                 


Gly Cys Pro Arg Arg Tyr Lys Pro Phe Asn Ala Arg Tyr Lys Leu Leu 
385                 390                 395                 400 


Ile His Met Arg Val His Ser Gly Glu Lys Pro Asn Lys Cys Thr Phe 
                405                 410                 415     


Glu Gly Cys Glu Lys Ala Phe Ser Arg Leu Glu Asn Leu Lys Ile His 
            420                 425                 430         


Leu Arg Ser His Thr Gly Glu Lys Pro Tyr Leu Cys Gln His Pro Gly 
        435                 440                 445             


Cys Gln Lys Ala Phe Ser Asn Ser Ser Asp Arg Ala Lys His Gln Arg 
    450                 455                 460                 


Thr His Leu Asp Thr Lys Pro Tyr Ala Cys Gln Ile Pro Gly Cys Thr 
465                 470                 475                 480 


Lys Arg Tyr Thr Asp Pro Ser Ser Leu Arg Lys His Val Lys Ala His 
                485                 490                 495     


Ser Ser Lys Glu Gln Gln Ala Arg Lys Lys Leu Arg Ser Ser Thr Glu 
            500                 505                 510         


Leu His Pro Asp Leu Leu Thr Asp Cys Leu Thr Val Gln Ser Leu Gln 
        515                 520                 525             


Pro Ala Thr Ser Pro Arg Asp Ala Ala Ala Glu Gly Thr Val Gly Arg 
    530                 535                 540                 


Ser Pro Gly Pro Gly Pro Asp Leu Tyr Ser Ala Pro Ile Phe Ser Ser 
545                 550                 555                 560 


Asn Tyr Ser Ser Arg Ser Gly Thr Ala Ala Gly Ala Val Pro Pro Pro 
                565                 570                 575     


His Pro Val Ser His Pro Ser Pro Gly His Asn Val Gln Gly Ser Pro 
            580                 585                 590         


His Asn Pro Ser Ser Gln Leu Pro Pro Leu Thr Ala Val Asp Ala Gly 
        595                 600                 605             


Ala Glu Arg Phe Ala Pro Ser Ala Pro Ser Pro His His Ile Ser Pro 
    610                 615                 620                 


Arg Arg Val Pro Ala Pro Ser Ser Ile Leu Gln Arg Thr Gln Pro Pro 
625                 630                 635                 640 


Tyr Thr Gln Gln Pro Ser Gly Ser His Leu Lys Ser Tyr Gln Pro Glu 
                645                 650                 655     


Thr Asn Ser Ser Phe Gln Pro Asn Gly Ile His Val His Gly Phe Tyr 
            660                 665                 670         


Gly Gln Leu Gln Lys Phe Cys Pro Pro His Tyr Pro Asp Ser Gln Arg 
        675                 680                 685             


Ile Val Pro Pro Val Ser Ser Cys Ser Val Val Pro Ser Phe Glu Asp 
    690                 695                 700                 


Cys Leu Val Pro Thr Ser Met Gly Gln Ala Ser Phe Asp Val Phe His 
705                 710                 715                 720 


Arg Ala Phe Ser Thr His Ser Gly Ile Thr Val Tyr Asp Leu Pro Ser 
                725                 730                 735     


Ser Ser Ser Ser Leu Phe Gly Glu Ser Leu Arg Ser Gly Ala Glu Asp 
            740                 745                 750         


Ala Thr Phe Leu Gln Ile Ser Thr Val Asp Arg Cys Pro Ser Gln Leu 
        755                 760                 765             


Ser Ser Val Tyr Thr Glu Gly 
    770                 775 


<210>  6018
<211>  244
<212>  PRT
<213>  Homo Sapiens

<400>  6018

Met Asn Gly Arg Ser Cys Ser Met Ser Leu His Arg Thr Ser Gly Thr 
1               5                   10                  15      


Pro Gln Gly Pro Arg Met Val Ser Gly His His Ile Pro Ala Ile Arg 
            20                  25                  30          


Ala His Ser Gly Thr Pro Gly Pro Ser Pro Cys Gly Ser Thr Ser Ser 
        35                  40                  45              


Pro Thr Met Ala Ser Leu Ala Asn Asn Leu His Leu Lys Met Pro Ser 
    50                  55                  60                  


Gly Gly Gly Met Ala Pro Gln Asn Asn Val Ala Glu Ser Arg Ile His 
65                  70                  75                  80  


Leu Pro Ala Leu Ser Pro Arg Arg Gln Met Leu Thr Asn Gly Lys Pro 
                85                  90                  95      


Arg Phe Gln Val Thr Gln Ala Gly Gly Met Ser Gly Ser His Thr Leu 
            100                 105                 110         


Lys Pro Lys Gln Gln Glu Phe Gly Ser Pro Phe Pro Pro Asn Pro Gly 
        115                 120                 125             


Lys Gly Ala Leu Gly Phe Gly Pro Gln Cys Lys Ser Ile Gly Lys Gly 
    130                 135                 140                 


Ser Cys Asn Asn Leu Val Val Thr Ser Ser Pro Met Met Val Gln Arg 
145                 150                 155                 160 


Leu Gly Leu Ile Ser Pro Pro Ala Ser Gln Val Ser Thr Ala Cys Asn 
                165                 170                 175     


Gln Ile Ser Pro Ser Leu Gln Arg Ala Met Asn Ala Ala Asn Leu Asn 
            180                 185                 190         


Ile Pro Pro Ser Asp Thr Arg Ser Leu Ile Ser Arg Glu Ser Leu Ala 
        195                 200                 205             


Ser Thr Thr Leu Ser Leu Thr Glu Ser Gln Ser Ala Ser Ser Met Lys 
    210                 215                 220                 


Gln Glu Trp Ser Gln Gly Tyr Arg Ala Leu Pro Ser Leu Ser Asn His 
225                 230                 235                 240 


Gly Ser Gln Asn 
                


<210>  6019
<211>  244
<212>  PRT
<213>  Homo Sapiens

<400>  6019

Met Asn Gly Arg Ser Cys Ser Met Ser Leu His Arg Thr Ser Gly Thr 
1               5                   10                  15      


Pro Gln Gly Pro Arg Met Val Ser Gly His His Ile Pro Ala Ile Arg 
            20                  25                  30          


Ala His Ser Gly Thr Pro Gly Pro Ser Pro Cys Gly Ser Thr Ser Ser 
        35                  40                  45              


Pro Thr Met Ala Ser Leu Ala Asn Asn Leu His Leu Lys Met Pro Ser 
    50                  55                  60                  


Gly Gly Gly Met Ala Pro Gln Asn Asn Val Ala Glu Ser Arg Ile His 
65                  70                  75                  80  


Leu Pro Ala Leu Ser Pro Arg Arg Gln Met Leu Thr Asn Gly Lys Pro 
                85                  90                  95      


Arg Phe Gln Val Thr Gln Ala Gly Gly Met Ser Gly Ser His Thr Leu 
            100                 105                 110         


Lys Pro Lys Gln Gln Glu Phe Gly Ser Pro Phe Pro Pro Asn Pro Gly 
        115                 120                 125             


Lys Gly Ala Leu Gly Phe Gly Pro Gln Cys Lys Ser Ile Gly Lys Gly 
    130                 135                 140                 


Ser Cys Asn Asn Leu Val Val Thr Ser Ser Pro Met Met Val Gln Arg 
145                 150                 155                 160 


Leu Gly Leu Ile Ser Pro Pro Ala Ser Gln Val Ser Thr Ala Cys Asn 
                165                 170                 175     


Gln Ile Ser Pro Ser Leu Gln Arg Ala Met Asn Ala Ala Asn Leu Asn 
            180                 185                 190         


Ile Pro Pro Ser Asp Thr Arg Ser Leu Ile Ser Arg Glu Ser Leu Ala 
        195                 200                 205             


Ser Thr Thr Leu Ser Leu Thr Glu Ser Gln Ser Ala Ser Ser Met Lys 
    210                 215                 220                 


Gln Glu Trp Ser Gln Gly Tyr Arg Ala Leu Pro Ser Leu Ser Asn His 
225                 230                 235                 240 


Gly Ser Gln Asn 
                


<210>  6020
<211>  930
<212>  PRT
<213>  Homo Sapiens

<400>  6020

Met Asn Gly Arg Ser Cys Ser Met Ser Leu His Arg Thr Ser Gly Thr 
1               5                   10                  15      


Pro Gln Gly Pro Arg Met Val Ser Gly His His Ile Pro Ala Ile Arg 
            20                  25                  30          


Ala His Ser Gly Thr Pro Gly Pro Ser Pro Cys Gly Ser Thr Ser Ser 
        35                  40                  45              


Pro Thr Met Ala Ser Leu Ala Asn Asn Leu His Leu Lys Met Pro Ser 
    50                  55                  60                  


Gly Gly Gly Met Ala Pro Gln Asn Asn Val Ala Glu Ser Arg Ile His 
65                  70                  75                  80  


Leu Pro Ala Leu Ser Pro Arg Arg Gln Met Leu Thr Asn Gly Lys Pro 
                85                  90                  95      


Arg Phe Gln Val Thr Gln Ala Gly Gly Met Ser Gly Ser His Thr Leu 
            100                 105                 110         


Lys Pro Lys Gln Gln Glu Phe Gly Ser Pro Phe Pro Pro Asn Pro Gly 
        115                 120                 125             


Lys Gly Ala Leu Gly Phe Gly Pro Gln Cys Lys Ser Ile Gly Lys Gly 
    130                 135                 140                 


Ser Cys Asn Asn Leu Val Val Thr Ser Ser Pro Met Met Val Gln Arg 
145                 150                 155                 160 


Leu Gly Leu Ile Ser Pro Pro Ala Ser Gln Val Ser Thr Ala Cys Asn 
                165                 170                 175     


Gln Ile Ser Pro Ser Leu Gln Arg Ala Met Asn Ala Ala Asn Leu Asn 
            180                 185                 190         


Ile Pro Pro Ser Asp Thr Arg Ser Leu Ile Ser Arg Glu Ser Leu Ala 
        195                 200                 205             


Ser Thr Thr Leu Ser Leu Thr Glu Ser Gln Ser Ala Ser Ser Met Lys 
    210                 215                 220                 


Gln Glu Trp Ser Gln Gly Tyr Arg Ala Leu Pro Ser Leu Ser Asn His 
225                 230                 235                 240 


Gly Ser Gln Asn Gly Leu Asp Leu Gly Asp Leu Leu Ser Leu Pro Pro 
                245                 250                 255     


Gly Thr Ser Met Ser Ser Asn Ser Val Ser Asn Ser Leu Pro Ser Tyr 
            260                 265                 270         


Leu Phe Gly Thr Glu Ser Ser His Ser Pro Tyr Pro Ser Pro Arg His 
        275                 280                 285             


Ser Ser Thr Arg Ser His Ser Ala Arg Ser Lys Lys Arg Ala Leu Ser 
    290                 295                 300                 


Leu Ser Pro Leu Ser Asp Gly Ile Gly Ile Asp Phe Asn Thr Ile Ile 
305                 310                 315                 320 


Arg Thr Ser Pro Thr Ser Leu Val Ala Tyr Ile Asn Gly Ser Arg Ala 
                325                 330                 335     


Ser Pro Ala Asn Leu Ser Pro Gln Pro Glu Val Tyr Gly His Phe Leu 
            340                 345                 350         


Gly Val Arg Gly Ser Cys Ile Pro Gln Pro Arg Pro Val Pro Gly Ser 
        355                 360                 365             


Gln Lys Gly Val Leu Val Ala Pro Gly Gly Leu Ala Leu Pro Ala Tyr 
    370                 375                 380                 


Gly Glu Asp Gly Ala Leu Glu His Glu Arg Met Gln Gln Leu Glu His 
385                 390                 395                 400 


Gly Gly Leu Gln Pro Gly Leu Val Asn His Met Val Val Gln His Gly 
                405                 410                 415     


Leu Pro Gly Pro Asp Ser Gln Ser Ala Gly Leu Phe Lys Thr Glu Arg 
            420                 425                 430         


Leu Glu Glu Phe Pro Gly Ser Thr Val Asp Leu Pro Pro Ala Pro Pro 
        435                 440                 445             


Leu Pro Pro Leu Pro Pro Pro Pro Gly Pro Pro Pro Pro Tyr His Ala 
    450                 455                 460                 


His Ala His Leu His His Pro Glu Leu Gly Pro His Ala Gln Gln Leu 
465                 470                 475                 480 


Ala Leu Pro Gln Ala Thr Leu Asp Asp Asp Gly Glu Met Asp Gly Ile 
                485                 490                 495     


Gly Gly Lys His Cys Cys Arg Trp Ile Asp Cys Ser Ala Leu Tyr Asp 
            500                 505                 510         


Gln Gln Glu Glu Leu Val Arg His Ile Glu Lys Val His Ile Asp Gln 
        515                 520                 525             


Arg Lys Gly Glu Asp Phe Thr Cys Phe Trp Ala Gly Cys Pro Arg Arg 
    530                 535                 540                 


Tyr Lys Pro Phe Asn Ala Arg Tyr Lys Leu Leu Ile His Met Arg Val 
545                 550                 555                 560 


His Ser Gly Glu Lys Pro Asn Lys Cys Thr Phe Glu Gly Cys Glu Lys 
                565                 570                 575     


Ala Phe Ser Arg Leu Glu Asn Leu Lys Ile His Leu Arg Ser His Thr 
            580                 585                 590         


Gly Glu Lys Pro Tyr Leu Cys Gln His Pro Gly Cys Gln Lys Ala Phe 
        595                 600                 605             


Ser Asn Ser Ser Asp Arg Ala Lys His Gln Arg Thr His Leu Asp Thr 
    610                 615                 620                 


Lys Pro Tyr Ala Cys Gln Ile Pro Gly Cys Thr Lys Arg Tyr Thr Asp 
625                 630                 635                 640 


Pro Ser Ser Leu Arg Lys His Val Lys Ala His Ser Ser Lys Glu Gln 
                645                 650                 655     


Gln Ala Arg Lys Lys Leu Arg Ser Ser Thr Glu Leu His Pro Asp Leu 
            660                 665                 670         


Leu Thr Asp Cys Leu Thr Val Gln Ser Leu Gln Pro Ala Thr Ser Pro 
        675                 680                 685             


Arg Asp Ala Ala Ala Glu Gly Thr Val Gly Arg Ser Pro Gly Pro Gly 
    690                 695                 700                 


Pro Asp Leu Tyr Ser Ala Pro Ile Phe Ser Ser Asn Tyr Ser Ser Arg 
705                 710                 715                 720 


Ser Gly Thr Ala Ala Gly Ala Val Pro Pro Pro His Pro Val Ser His 
                725                 730                 735     


Pro Ser Pro Gly His Asn Val Gln Gly Ser Pro His Asn Pro Ser Ser 
            740                 745                 750         


Gln Leu Pro Pro Leu Thr Ala Val Asp Ala Gly Ala Glu Arg Phe Ala 
        755                 760                 765             


Pro Ser Ala Pro Ser Pro His His Ile Ser Pro Arg Arg Val Pro Ala 
    770                 775                 780                 


Pro Ser Ser Ile Leu Gln Arg Thr Gln Pro Pro Tyr Thr Gln Gln Pro 
785                 790                 795                 800 


Ser Gly Ser His Leu Lys Ser Tyr Gln Pro Glu Thr Asn Ser Ser Phe 
                805                 810                 815     


Gln Pro Asn Gly Ile His Val His Gly Phe Tyr Gly Gln Leu Gln Lys 
            820                 825                 830         


Phe Cys Pro Pro His Tyr Pro Asp Ser Gln Arg Ile Val Pro Pro Val 
        835                 840                 845             


Ser Ser Cys Ser Val Val Pro Ser Phe Glu Asp Cys Leu Val Pro Thr 
    850                 855                 860                 


Ser Met Gly Gln Ala Ser Phe Asp Val Phe His Arg Ala Phe Ser Thr 
865                 870                 875                 880 


His Ser Gly Ile Thr Val Tyr Asp Leu Pro Ser Ser Ser Ser Ser Leu 
                885                 890                 895     


Phe Gly Glu Ser Leu Arg Ser Gly Ala Glu Asp Ala Thr Phe Leu Gln 
            900                 905                 910         


Ile Ser Thr Val Asp Arg Cys Pro Ser Gln Leu Ser Ser Val Tyr Thr 
        915                 920                 925             


Glu Gly 
    930 


<210>  6021
<211>  142
<212>  PRT
<213>  Homo Sapiens

<400>  6021

Met Asn Gly Arg Ser Cys Ser Met Ser Leu His Arg Thr Ser Gly Thr 
1               5                   10                  15      


Pro Gln Gly Pro Arg Met Val Ser Gly His His Ile Pro Ala Ile Arg 
            20                  25                  30          


Ala His Ser Gly Thr Pro Gly Pro Ser Pro Cys Gly Ser Thr Ser Ser 
        35                  40                  45              


Pro Thr Met Ala Ser Leu Ala Asn Asn Leu His Leu Lys Met Pro Ser 
    50                  55                  60                  


Gly Gly Gly Met Ala Pro Gln Asn Asn Val Ala Glu Ser Arg Ile His 
65                  70                  75                  80  


Leu Pro Ala Leu Ser Pro Arg Arg Gln Met Leu Thr Asn Gly Lys Pro 
                85                  90                  95      


Arg Phe Gln Val Thr Gln Ala Gly Gly Met Ser Gly Ser His Thr Leu 
            100                 105                 110         


Lys Pro Lys Gln Gln Glu Phe Gly Ser Pro Phe Pro Pro Asn Pro Gly 
        115                 120                 125             


Lys Gly Pro Leu Phe Arg Val Ser Leu Trp Arg Pro Arg Pro 
    130                 135                 140         


<210>  6022
<211>  75
<212>  PRT
<213>  Homo Sapiens

<400>  6022

Phe Asn Leu Thr Phe Gly Ala Ser Thr Gly Pro Gly Tyr Trp Asp Gln 
1               5                   10                  15      


His Tyr Leu Ser Trp Ser Met Leu Leu Gly Val Gly Phe Pro Pro Val 
            20                  25                  30          


Asp Gly Leu Ser Pro Leu Val Leu Gly Ile Met Ala Val Ala Leu Gly 
        35                  40                  45              


Ala Pro Gly Leu Met Leu Leu Gly Gly Gly Leu Val Leu Leu Leu His 
    50                  55                  60                  


His Lys Lys Tyr Ser Glu Tyr Gln Ser Ile Asn 
65                  70                  75  


<210>  6023
<211>  320
<212>  PRT
<213>  Homo Sapiens

<400>  6023

Met Arg Gly Ser Val Glu Cys Thr Trp Gly Trp Gly His Cys Ala Pro 
1               5                   10                  15      


Ser Pro Leu Leu Leu Trp Thr Leu Leu Leu Phe Ala Ala Pro Phe Gly 
            20                  25                  30          


Leu Leu Gly Glu Lys Thr Arg Gln Leu Leu Glu Phe Asp Ser Thr Asn 
        35                  40                  45              


Val Ser Asp Thr Ala Ala Lys Pro Leu Gly Arg Pro Tyr Pro Pro Tyr 
    50                  55                  60                  


Ser Leu Ala Asp Phe Ser Trp Asn Asn Ile Thr Asp Ser Leu Asp Pro 
65                  70                  75                  80  


Ala Thr Leu Ser Ala Thr Phe Gln Gly His Pro Met Asn Asp Pro Thr 
                85                  90                  95      


Arg Thr Phe Ala Asn Gly Ser Leu Ala Phe Arg Val Gln Ala Phe Ser 
            100                 105                 110         


Arg Ser Ser Arg Pro Ala Gln Pro Pro Arg Leu Leu His Thr Ala Asp 
        115                 120                 125             


Thr Cys Gln Leu Glu Val Ala Leu Ile Gly Ala Ser Pro Arg Gly Asn 
    130                 135                 140                 


Arg Ser Leu Phe Gly Leu Glu Val Ala Thr Leu Gly Gln Gly Pro Asp 
145                 150                 155                 160 


Cys Pro Ser Met Gln Glu Gln His Ser Ile Asp Asp Glu Tyr Ala Pro 
                165                 170                 175     


Ala Val Phe Gln Leu Asp Gln Leu Leu Trp Gly Ser Leu Pro Ser Gly 
            180                 185                 190         


Phe Ala Gln Trp Arg Pro Val Ala Tyr Ser Gln Lys Pro Gly Gly Arg 
        195                 200                 205             


Glu Ser Ala Leu Pro Cys Gln Ala Ser Pro Leu His Pro Ala Leu Ala 
    210                 215                 220                 


Tyr Ser Leu Pro Gln Ser Pro Ile Val Arg Ala Phe Phe Gly Ser Gln 
225                 230                 235                 240 


Asn Asn Phe Cys Ala Phe Asn Leu Thr Phe Gly Ala Ser Thr Gly Pro 
                245                 250                 255     


Gly Tyr Trp Asp Gln His Tyr Leu Ser Trp Ser Met Leu Leu Gly Val 
            260                 265                 270         


Gly Phe Pro Pro Val Asp Gly Leu Ser Pro Leu Val Leu Gly Ile Met 
        275                 280                 285             


Ala Val Ala Leu Gly Ala Pro Gly Leu Met Leu Leu Gly Gly Gly Leu 
    290                 295                 300                 


Val Leu Leu Leu His His Lys Lys Tyr Ser Glu Tyr Gln Ser Ile Asn 
305                 310                 315                 320 


<210>  6024
<211>  183
<212>  PRT
<213>  Homo Sapiens

<400>  6024

Met Arg Gly Ser Val Glu Cys Thr Trp Gly Trp Gly His Cys Ala Pro 
1               5                   10                  15      


Ser Pro Leu Leu Leu Trp Thr Leu Leu Leu Phe Ala Ala Pro Phe Gly 
            20                  25                  30          


Leu Leu Gly Glu Lys Thr Arg Gln Leu Leu Glu Phe Asp Ser Thr Asn 
        35                  40                  45              


Val Ser Asp Thr Ala Ala Lys Pro Leu Gly Arg Pro Tyr Pro Pro Tyr 
    50                  55                  60                  


Ser Leu Ala Asp Phe Ser Trp Asn Asn Ile Thr Asp Ser Leu Asp Pro 
65                  70                  75                  80  


Ala Thr Leu Ser Ala Thr Phe Gln Gly His Pro Met Asn Asp Pro Thr 
                85                  90                  95      


Arg Thr Phe Ala Asn Gly Ser Leu Ala Phe Arg Val Gln Ala Phe Ser 
            100                 105                 110         


Arg Ser Ser Arg Pro Ala Gln Pro Pro Arg Leu Leu His Thr Ala Asp 
        115                 120                 125             


Thr Cys Gln Leu Glu Val Ala Leu Ile Gly Ala Ser Pro Arg Gly Asn 
    130                 135                 140                 


Arg Ser Leu Phe Gly Leu Glu Val Ala Thr Leu Gly Gln Gly Pro Asp 
145                 150                 155                 160 


Cys Pro Ser Met Gln Glu Gln His Ser Ile Asp Asp Glu Tyr Ala Pro 
                165                 170                 175     


Ala Val Phe Gln Arg Arg Asp 
            180             


<210>  6025
<211>  89
<212>  PRT
<213>  Homo Sapiens

<400>  6025

Met Arg Gly Ser Val Glu Cys Thr Trp Gly Trp Gly His Cys Ala Pro 
1               5                   10                  15      


Ser Pro Leu Leu Leu Trp Thr Leu Leu Leu Phe Ala Ala Pro Phe Gly 
            20                  25                  30          


Leu Leu Gly Glu Lys Thr Arg Gln Val Arg Arg Leu Gly Glu Asn Gln 
        35                  40                  45              


Gly Glu Glu Cys Arg Gly Glu Ser Ser Ser Gln Leu Glu Gly Gly Thr 
    50                  55                  60                  


Lys Asp Trp Gly Lys Ala Phe Gly Lys Thr Ile Ser Ser Ile Leu Leu 
65                  70                  75                  80  


Gly Arg Phe Leu Leu Glu Gln His His 
                85                  


<210>  6026
<211>  130
<212>  PRT
<213>  Homo Sapiens

<400>  6026

Met Arg Gly Ser Val Glu Cys Thr Trp Gly Trp Gly His Cys Ala Pro 
1               5                   10                  15      


Ser Pro Leu Leu Leu Trp Thr Leu Leu Leu Phe Ala Ala Pro Phe Gly 
            20                  25                  30          


Leu Leu Gly Glu Lys Thr Arg Gln Val Ser Leu Glu Val Ile Pro Asn 
        35                  40                  45              


Trp Leu Gly Pro Leu Gln Asn Leu Leu His Ile Arg Ala Val Gly Thr 
    50                  55                  60                  


Asn Ser Thr Leu His Tyr Val Trp Ser Ser Leu Gly Pro Leu Ala Val 
65                  70                  75                  80  


Val Met Val Ala Thr Asn Thr Pro His Ser Thr Leu Ser Val Asn Trp 
                85                  90                  95      


Ser Leu Leu Leu Ser Pro Glu Pro Asp Gly Gly Leu Met Val Leu Pro 
            100                 105                 110         


Lys Asp Ser Ile Gln Phe Ser Ser Ala Leu Val Phe Thr Arg Gly Ser 
        115                 120                 125             


Cys Cys 
    130 


<210>  6027
<211>  406
<212>  PRT
<213>  Homo Sapiens

<400>  6027

Met Arg Gly Ser Val Glu Cys Thr Trp Gly Trp Gly His Cys Ala Pro 
1               5                   10                  15      


Ser Pro Leu Leu Leu Trp Thr Leu Leu Leu Phe Ala Ala Pro Phe Gly 
            20                  25                  30          


Leu Leu Gly Glu Lys Thr Arg Gln Val Ser Leu Glu Val Ile Pro Asn 
        35                  40                  45              


Trp Leu Gly Pro Leu Gln Asn Leu Leu His Ile Arg Ala Val Gly Thr 
    50                  55                  60                  


Asn Ser Thr Leu His Tyr Val Trp Ser Ser Leu Gly Pro Leu Ala Val 
65                  70                  75                  80  


Val Met Val Ala Thr Asn Thr Pro His Ser Thr Leu Ser Val Asn Trp 
                85                  90                  95      


Ser Leu Leu Leu Ser Pro Glu Pro Asp Gly Gly Leu Met Val Leu Pro 
            100                 105                 110         


Lys Asp Ser Ile Gln Phe Ser Ser Ala Leu Val Phe Thr Arg Leu Leu 
        115                 120                 125             


Glu Phe Asp Ser Thr Asn Val Ser Asp Thr Ala Ala Lys Pro Leu Gly 
    130                 135                 140                 


Arg Pro Tyr Pro Pro Tyr Ser Leu Ala Asp Phe Ser Trp Asn Asn Ile 
145                 150                 155                 160 


Thr Asp Ser Leu Asp Pro Ala Thr Leu Ser Ala Thr Phe Gln Gly His 
                165                 170                 175     


Pro Met Asn Asp Pro Thr Arg Thr Phe Ala Asn Gly Ser Leu Ala Phe 
            180                 185                 190         


Arg Val Gln Ala Phe Ser Arg Ser Ser Arg Pro Ala Gln Pro Pro Arg 
        195                 200                 205             


Leu Leu His Thr Ala Asp Thr Cys Gln Leu Glu Val Ala Leu Ile Gly 
    210                 215                 220                 


Ala Ser Pro Arg Gly Asn Arg Ser Leu Phe Gly Leu Glu Val Ala Thr 
225                 230                 235                 240 


Leu Gly Gln Gly Pro Asp Cys Pro Ser Met Gln Glu Gln His Ser Ile 
                245                 250                 255     


Asp Asp Glu Tyr Ala Pro Ala Val Phe Gln Leu Asp Gln Leu Leu Trp 
            260                 265                 270         


Gly Ser Leu Pro Ser Gly Phe Ala Gln Trp Arg Pro Val Ala Tyr Ser 
        275                 280                 285             


Gln Lys Pro Gly Gly Arg Glu Ser Ala Leu Pro Cys Gln Ala Ser Pro 
    290                 295                 300                 


Leu His Pro Ala Leu Ala Tyr Ser Leu Pro Gln Ser Pro Ile Val Arg 
305                 310                 315                 320 


Ala Phe Phe Gly Ser Gln Asn Asn Phe Cys Ala Phe Asn Leu Thr Phe 
                325                 330                 335     


Gly Ala Ser Thr Gly Pro Gly Tyr Trp Asp Gln His Tyr Leu Ser Trp 
            340                 345                 350         


Ser Met Leu Leu Gly Val Gly Phe Pro Pro Val Asp Gly Leu Ser Pro 
        355                 360                 365             


Leu Val Leu Gly Ile Met Ala Val Ala Leu Gly Ala Pro Gly Leu Met 
    370                 375                 380                 


Leu Leu Gly Gly Gly Leu Val Leu Leu Leu His His Lys Lys Tyr Ser 
385                 390                 395                 400 


Glu Tyr Gln Ser Ile Asn 
                405     


<210>  6028
<211>  331
<212>  PRT
<213>  Homo Sapiens

<400>  6028

Met Arg Gly Ser Val Glu Cys Thr Trp Gly Trp Gly His Cys Ala Pro 
1               5                   10                  15      


Ser Pro Leu Leu Leu Trp Thr Leu Leu Leu Phe Ala Ala Pro Phe Gly 
            20                  25                  30          


Leu Leu Gly Glu Lys Thr Arg Gln Val Ser Leu Glu Val Ile Pro Asn 
        35                  40                  45              


Trp Leu Gly Pro Leu Gln Asn Leu Leu His Ile Arg Ala Val Gly Thr 
    50                  55                  60                  


Asn Ser Thr Leu His Tyr Val Trp Ser Ser Leu Gly Pro Leu Ala Val 
65                  70                  75                  80  


Val Met Val Ala Thr Asn Thr Pro His Ser Thr Leu Ser Val Asn Trp 
                85                  90                  95      


Ser Leu Leu Leu Ser Pro Glu Pro Asp Gly Gly Leu Met Val Leu Pro 
            100                 105                 110         


Lys Asp Ser Ile Gln Phe Ser Ser Ala Leu Val Phe Thr Arg Leu Leu 
        115                 120                 125             


Glu Phe Asp Ser Thr Asn Val Ser Asp Thr Ala Ala Lys Pro Leu Gly 
    130                 135                 140                 


Arg Pro Tyr Pro Pro Tyr Ser Leu Ala Asp Phe Ser Trp Asn Asn Ile 
145                 150                 155                 160 


Thr Asp Ser Leu Asp Pro Ala Thr Leu Ser Ala Thr Phe Gln Gly His 
                165                 170                 175     


Pro Met Asn Asp Pro Thr Arg Thr Phe Ala Asn Gly Ser Leu Ala Phe 
            180                 185                 190         


Arg Val Gln Ala Phe Ser Arg Ser Ser Arg Pro Ala Gln Pro Pro Arg 
        195                 200                 205             


Leu Leu His Thr Ala Asp Thr Cys Gln Leu Glu Val Ala Leu Ile Gly 
    210                 215                 220                 


Ala Ser Pro Arg Gly Asn Arg Ser Leu Phe Gly Leu Glu Val Ala Thr 
225                 230                 235                 240 


Leu Gly Gln Gly Pro Asp Cys Pro Ser Met Gln Glu Gln His Ser Ile 
                245                 250                 255     


Asp Asp Glu Tyr Ala Pro Ala Val Phe Gln Val Asp Ala Pro Gly Cys 
            260                 265                 270         


Gly Leu Pro Ser Ser Gly Arg Leu Val Pro Thr Ser Pro Gly His His 
        275                 280                 285             


Gly Ser Gly Pro Gly Cys Pro Arg Ala His Ala Ala Arg Gly Arg Leu 
    290                 295                 300                 


Gly Ser Ala Ala Ala Pro Gln Glu Val Leu Arg Val Pro Val His Lys 
305                 310                 315                 320 


Leu Arg Pro Ala Leu Trp Arg Glu Gly His Tyr 
                325                 330     


<210>  6029
<211>  325
<212>  PRT
<213>  Homo Sapiens

<400>  6029

Met Val Ala Thr Asn Thr Pro His Ser Thr Leu Ser Val Asn Trp Ser 
1               5                   10                  15      


Leu Leu Leu Ser Pro Glu Pro Asp Gly Gly Leu Met Val Leu Pro Lys 
            20                  25                  30          


Asp Ser Ile Gln Phe Ser Ser Ala Leu Val Phe Thr Arg Leu Leu Glu 
        35                  40                  45              


Phe Asp Ser Thr Asn Val Ser Asp Thr Ala Ala Lys Pro Leu Gly Arg 
    50                  55                  60                  


Pro Tyr Pro Pro Tyr Ser Leu Ala Asp Phe Ser Trp Asn Asn Ile Thr 
65                  70                  75                  80  


Asp Ser Leu Asp Pro Ala Thr Leu Ser Ala Thr Phe Gln Gly His Pro 
                85                  90                  95      


Met Asn Asp Pro Thr Arg Thr Phe Ala Asn Gly Ser Leu Ala Phe Arg 
            100                 105                 110         


Val Gln Ala Phe Ser Arg Ser Ser Arg Pro Ala Gln Pro Pro Arg Leu 
        115                 120                 125             


Leu His Thr Ala Asp Thr Cys Gln Leu Glu Val Ala Leu Ile Gly Ala 
    130                 135                 140                 


Ser Pro Arg Gly Asn Arg Ser Leu Phe Gly Leu Glu Val Ala Thr Leu 
145                 150                 155                 160 


Gly Gln Gly Pro Asp Cys Pro Ser Met Gln Glu Gln His Ser Ile Asp 
                165                 170                 175     


Asp Glu Tyr Ala Pro Ala Val Phe Gln Leu Asp Gln Leu Leu Trp Gly 
            180                 185                 190         


Ser Leu Pro Ser Gly Phe Ala Gln Trp Arg Pro Val Ala Tyr Ser Gln 
        195                 200                 205             


Lys Pro Gly Gly Arg Glu Ser Ala Leu Pro Cys Gln Ala Ser Pro Leu 
    210                 215                 220                 


His Pro Ala Leu Ala Tyr Ser Leu Pro Gln Ser Pro Ile Val Arg Ala 
225                 230                 235                 240 


Phe Phe Gly Ser Gln Asn Asn Phe Cys Ala Phe Asn Leu Thr Phe Gly 
                245                 250                 255     


Ala Ser Thr Gly Pro Gly Tyr Trp Asp Gln His Tyr Leu Ser Trp Ser 
            260                 265                 270         


Met Leu Leu Gly Val Gly Phe Pro Pro Val Asp Gly Leu Ser Pro Leu 
        275                 280                 285             


Val Leu Gly Ile Met Ala Val Ala Leu Gly Ala Pro Gly Leu Met Leu 
    290                 295                 300                 


Leu Gly Gly Gly Leu Val Leu Leu Leu His His Lys Lys Tyr Ser Glu 
305                 310                 315                 320 


Tyr Gln Ser Ile Asn 
                325 


<210>  6030
<211>  111
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6030

Xaa Pro Ser Met Gln Glu Gln His Ser Ile Asp Asp Glu Tyr Ala Pro 
1               5                   10                  15      


Ala Val Phe Gln Ser Pro Ile Val Arg Ala Phe Phe Gly Ser Gln Asn 
            20                  25                  30          


Asn Phe Cys Ala Phe Asn Leu Thr Phe Gly Ala Ser Thr Gly Pro Gly 
        35                  40                  45              


Tyr Trp Asp Gln His Tyr Leu Ser Trp Ser Met Leu Leu Gly Val Gly 
    50                  55                  60                  


Phe Pro Pro Val Asp Gly Leu Ser Pro Leu Val Leu Gly Ile Met Ala 
65                  70                  75                  80  


Val Ala Leu Gly Ala Pro Gly Leu Met Leu Leu Gly Gly Gly Leu Val 
                85                  90                  95      


Leu Leu Leu His His Lys Lys Tyr Ser Glu Tyr Gln Ser Ile Asn 
            100                 105                 110     


<210>  6031
<211>  46
<212>  PRT
<213>  Homo Sapiens

<400>  6031

Met Lys Phe Leu Leu Thr Thr Ala Phe Leu Ile Leu Ile Ser Leu Trp 
1               5                   10                  15      


Val Glu Glu Ala Tyr Ser Lys Glu Lys Ser Ser Lys Lys Gly Lys Gly 
            20                  25                  30          


Lys Lys Lys Gln Tyr Leu Cys Pro Ser Glu Arg Leu Tyr His 
        35                  40                  45      


<210>  6032
<211>  46
<212>  PRT
<213>  Homo Sapiens

<400>  6032

Met Lys Phe Leu Leu Thr Thr Ala Phe Leu Ile Leu Ile Ser Leu Trp 
1               5                   10                  15      


Val Glu Glu Ala Tyr Ser Lys Glu Lys Ser Ser Lys Lys Gly Lys Gly 
            20                  25                  30          


Lys Lys Lys Gln Tyr Leu Cys Pro Ser Glu Arg Leu Tyr His 
        35                  40                  45      


<210>  6033
<211>  56
<212>  PRT
<213>  Homo Sapiens

<400>  6033

Met Lys Phe Leu Leu Thr Thr Ala Phe Leu Ile Leu Ile Ser Leu Trp 
1               5                   10                  15      


Val Glu Glu Ala Tyr Ser Lys Glu Lys Ser Ser Lys Lys Gly Lys Gly 
            20                  25                  30          


Lys Lys Lys Gln Tyr Leu Cys Pro Ser Leu Val Arg Pro Asp Ala Lys 
        35                  40                  45              


Lys Phe Val Leu Leu Ser Leu Ile 
    50                  55      


<210>  6034
<211>  497
<212>  PRT
<213>  Homo Sapiens

<400>  6034

Met Lys Phe Leu Leu Thr Thr Ala Phe Leu Ile Leu Ile Ser Leu Trp 
1               5                   10                  15      


Val Glu Glu Ala Tyr Ser Lys Glu Lys Ser Ser Lys Lys Gly Lys Gly 
            20                  25                  30          


Lys Lys Lys Gln Tyr Leu Cys Pro Ser Gln Gln Ser Ala Glu Asp Leu 
        35                  40                  45              


Ala Arg Val Pro Ala Asn Ser Thr Ser Asn Ile Leu Asn Arg Leu Leu 
    50                  55                  60                  


Val Ser Tyr Asp Pro Arg Ile Arg Pro Asn Phe Lys Gly Ile Pro Val 
65                  70                  75                  80  


Asp Val Val Val Asn Ile Phe Ile Asn Ser Phe Gly Ser Ile Gln Glu 
                85                  90                  95      


Thr Thr Met Asp Tyr Arg Val Asn Ile Phe Leu Arg Gln Lys Trp Asn 
            100                 105                 110         


Asp Pro Arg Leu Lys Leu Pro Ser Asp Phe Arg Gly Ser Asp Ala Leu 
        115                 120                 125             


Thr Val Asp Pro Thr Met Tyr Lys Cys Leu Trp Lys Pro Asp Leu Phe 
    130                 135                 140                 


Phe Ala Asn Glu Lys Ser Ala Asn Phe His Asp Val Thr Gln Glu Asn 
145                 150                 155                 160 


Ile Leu Leu Phe Ile Phe Arg Asp Gly Asp Val Leu Val Ser Met Arg 
                165                 170                 175     


Leu Ser Ile Thr Leu Ser Cys Pro Leu Asp Leu Thr Leu Phe Pro Met 
            180                 185                 190         


Asp Thr Gln Arg Cys Lys Met Gln Leu Glu Ser Phe Gly Tyr Thr Thr 
        195                 200                 205             


Asp Asp Leu Arg Phe Ile Trp Gln Ser Gly Asp Pro Val Gln Leu Glu 
    210                 215                 220                 


Lys Ile Ala Leu Pro Gln Phe Asp Ile Lys Lys Glu Asp Ile Glu Tyr 
225                 230                 235                 240 


Gly Asn Cys Thr Lys Tyr Tyr Lys Gly Thr Gly Tyr Tyr Thr Cys Val 
                245                 250                 255     


Glu Val Ile Phe Thr Leu Arg Arg Gln Val Gly Phe Tyr Met Met Gly 
            260                 265                 270         


Val Tyr Ala Pro Thr Leu Leu Ile Val Val Leu Ser Trp Leu Ser Phe 
        275                 280                 285             


Trp Ile Asn Pro Asp Ala Ser Ala Ala Arg Val Pro Leu Gly Ile Phe 
    290                 295                 300                 


Ser Val Leu Ser Leu Ala Ser Glu Cys Thr Thr Leu Ala Ala Glu Leu 
305                 310                 315                 320 


Pro Lys Val Ser Tyr Val Lys Ala Leu Asp Val Trp Leu Ile Ala Cys 
                325                 330                 335     


Leu Leu Phe Gly Phe Ala Ser Leu Val Glu Tyr Ala Val Val Gln Val 
            340                 345                 350         


Met Leu Asn Asn Pro Lys Arg Val Glu Ala Glu Lys Ala Arg Ile Ala 
        355                 360                 365             


Lys Ala Glu Gln Ala Asp Gly Lys Gly Gly Asn Val Ala Lys Lys Asn 
    370                 375                 380                 


Thr Val Asn Gly Thr Gly Thr Pro Val His Ile Ser Thr Leu Gln Val 
385                 390                 395                 400 


Gly Glu Thr Arg Cys Lys Lys Val Cys Thr Ser Lys Ser Asp Leu Arg 
                405                 410                 415     


Ser Asn Asp Phe Ser Ile Val Gly Ser Leu Pro Arg Asp Phe Glu Leu 
            420                 425                 430         


Ser Asn Tyr Asp Cys Tyr Gly Lys Pro Ile Glu Val Asn Asn Gly Leu 
        435                 440                 445             


Gly Lys Ser Gln Ala Lys Asn Asn Lys Lys Pro Pro Pro Ala Lys Pro 
    450                 455                 460                 


Val Ile Pro Thr Ala Ala Lys Arg Ile Asp Leu Tyr Ala Arg Ala Leu 
465                 470                 475                 480 


Phe Pro Phe Cys Phe Leu Phe Phe Asn Val Ile Tyr Trp Ser Ile Tyr 
                485                 490                 495     


Leu 
    


<210>  6035
<211>  497
<212>  PRT
<213>  Homo Sapiens

<400>  6035

Met Lys Phe Leu Leu Thr Thr Ala Phe Leu Ile Leu Ile Ser Leu Trp 
1               5                   10                  15      


Val Glu Glu Ala Tyr Ser Lys Glu Lys Ser Ser Lys Lys Gly Lys Gly 
            20                  25                  30          


Lys Lys Lys Gln Tyr Leu Cys Pro Ser Gln Gln Ser Ala Glu Asp Leu 
        35                  40                  45              


Ala Arg Val Pro Ala Asn Ser Thr Ser Asn Ile Leu Asn Arg Leu Leu 
    50                  55                  60                  


Val Ser Tyr Asp Pro Arg Ile Arg Pro Asn Phe Lys Gly Ile Pro Val 
65                  70                  75                  80  


Asp Val Val Val Asn Ile Phe Ile Asn Ser Phe Gly Ser Ile Gln Glu 
                85                  90                  95      


Thr Thr Met Asp Tyr Arg Val Asn Ile Phe Leu Arg Gln Lys Trp Asn 
            100                 105                 110         


Asp Pro Arg Leu Lys Leu Pro Ser Asp Phe Arg Gly Ser Asp Ala Leu 
        115                 120                 125             


Thr Val Asp Pro Thr Met Tyr Lys Cys Leu Trp Lys Pro Asp Leu Phe 
    130                 135                 140                 


Phe Ala Asn Glu Lys Ser Ala Asn Phe His Asp Val Thr Gln Glu Asn 
145                 150                 155                 160 


Ile Leu Leu Phe Ile Phe Arg Asp Gly Asp Val Leu Val Ser Met Arg 
                165                 170                 175     


Leu Ser Ile Thr Leu Ser Cys Pro Leu Asp Leu Thr Leu Phe Pro Met 
            180                 185                 190         


Asp Thr Gln Arg Cys Lys Met Gln Leu Glu Ser Phe Gly Tyr Thr Thr 
        195                 200                 205             


Asp Asp Leu Arg Phe Ile Trp Gln Ser Gly Asp Pro Val Gln Leu Glu 
    210                 215                 220                 


Lys Ile Ala Leu Pro Gln Phe Asp Ile Lys Lys Glu Asp Ile Glu Tyr 
225                 230                 235                 240 


Gly Asn Cys Thr Lys Tyr Tyr Lys Gly Thr Gly Tyr Tyr Thr Cys Val 
                245                 250                 255     


Glu Val Ile Phe Thr Leu Arg Arg Gln Val Gly Phe Tyr Met Met Gly 
            260                 265                 270         


Val Tyr Ala Pro Thr Leu Leu Ile Val Val Leu Ser Trp Leu Ser Phe 
        275                 280                 285             


Trp Ile Asn Pro Asp Ala Ser Ala Ala Arg Val Pro Leu Gly Ile Phe 
    290                 295                 300                 


Ser Val Leu Ser Leu Ala Ser Glu Cys Thr Thr Leu Ala Ala Glu Leu 
305                 310                 315                 320 


Pro Lys Val Ser Tyr Val Lys Ala Leu Asp Val Trp Leu Ile Ala Cys 
                325                 330                 335     


Leu Leu Phe Gly Phe Ala Ser Leu Val Glu Tyr Ala Val Val Gln Val 
            340                 345                 350         


Met Leu Asn Asn Pro Lys Arg Val Glu Ala Glu Lys Ala Arg Ile Ala 
        355                 360                 365             


Lys Ala Glu Gln Ala Asp Gly Lys Gly Gly Asn Val Ala Lys Lys Asn 
    370                 375                 380                 


Thr Val Asn Gly Thr Gly Thr Pro Val His Ile Ser Thr Leu Gln Val 
385                 390                 395                 400 


Gly Glu Thr Arg Cys Lys Lys Val Cys Thr Ser Lys Ser Asp Leu Arg 
                405                 410                 415     


Ser Asn Asp Phe Ser Ile Val Gly Ser Leu Pro Arg Asp Phe Glu Leu 
            420                 425                 430         


Ser Asn Tyr Asp Cys Tyr Gly Lys Pro Ile Glu Val Asn Asn Gly Leu 
        435                 440                 445             


Gly Lys Ser Gln Ala Lys Asn Asn Lys Lys Pro Pro Pro Ala Lys Pro 
    450                 455                 460                 


Val Ile Pro Thr Ala Ala Lys Arg Ile Asp Leu Tyr Ala Arg Ala Leu 
465                 470                 475                 480 


Phe Pro Phe Cys Phe Leu Phe Phe Asn Val Ile Tyr Trp Ser Ile Tyr 
                485                 490                 495     


Leu 
    


<210>  6036
<211>  303
<212>  PRT
<213>  Homo Sapiens

<400>  6036

Met Lys Phe Leu Leu Thr Thr Ala Phe Leu Ile Leu Ile Ser Leu Trp 
1               5                   10                  15      


Val Glu Glu Ala Tyr Ser Lys Glu Lys Ser Ser Lys Lys Gly Lys Gly 
            20                  25                  30          


Lys Lys Lys Gln Tyr Leu Cys Pro Ser Gln Gln Ser Ala Glu Asp Leu 
        35                  40                  45              


Ala Arg Val Pro Ala Asn Ser Thr Ser Asn Ile Leu Asn Arg Leu Leu 
    50                  55                  60                  


Val Ser Tyr Asp Pro Arg Ile Arg Pro Asn Phe Lys Gly Ile Pro Val 
65                  70                  75                  80  


Asp Val Val Val Asn Ile Phe Ile Asn Ser Phe Gly Ser Ile Gln Glu 
                85                  90                  95      


Thr Thr Met Asp Tyr Arg Val Asn Ile Phe Leu Arg Gln Lys Trp Asn 
            100                 105                 110         


Asp Pro Arg Leu Lys Leu Pro Ser Asp Phe Arg Gly Ser Asp Ala Leu 
        115                 120                 125             


Thr Val Asp Pro Thr Met Tyr Lys Cys Leu Trp Lys Pro Asp Leu Phe 
    130                 135                 140                 


Phe Ala Asn Glu Lys Ser Ala Asn Phe His Asp Val Thr Gln Glu Asn 
145                 150                 155                 160 


Ile Leu Leu Phe Ile Phe Arg Asp Gly Asp Val Leu Val Ser Met Arg 
                165                 170                 175     


Leu Ser Ile Thr Leu Ser Cys Pro Leu Asp Leu Thr Leu Phe Pro Met 
            180                 185                 190         


Asp Thr Gln Arg Cys Lys Met Gln Leu Glu Ser Phe Gly Tyr Thr Thr 
        195                 200                 205             


Asp Asp Leu Arg Phe Ile Trp Gln Ser Gly Asp Pro Val Gln Leu Glu 
    210                 215                 220                 


Lys Ile Ala Leu Pro Gln Phe Asp Ile Lys Lys Glu Asp Ile Glu Tyr 
225                 230                 235                 240 


Gly Asn Cys Thr Lys Tyr Tyr Lys Gly Thr Gly Tyr Tyr Thr Cys Val 
                245                 250                 255     


Glu Val Ile Phe Thr Leu Arg Arg Gln Val Gly Phe Tyr Met Met Gly 
            260                 265                 270         


Val Tyr Ala Pro Thr Leu Leu Ile Val Val Leu Ser Trp Leu Ser Phe 
        275                 280                 285             


Trp Ile Asn Pro Asp Ala Ser Ala Ala Arg Val Pro Leu Gly Trp 
    290                 295                 300             


<210>  6037
<211>  182
<212>  PRT
<213>  Homo Sapiens

<400>  6037

Ala Lys Ser Gly Val Ala Gly Gly Ile Leu Leu Val Val Pro Asn Val 
1               5                   10                  15      


Met Gly Met Met Cys Trp Ser Pro Pro Leu Asp Lys Met Gly Asn Ser 
            20                  25                  30          


Val Lys Gly Ile His Phe Cys His Asp Leu Val Ser Leu Cys Asn Phe 
        35                  40                  45              


His Asn Tyr Asp Asn Leu Arg His Phe Ala Lys Lys Leu Asp Pro Arg 
    50                  55                  60                  


Arg Glu Gly Gly Asp Gln Arg Val Lys Ser Val Ile Asn Leu Leu Phe 
65                  70                  75                  80  


Ala Ala Tyr Thr Gly Asp Val Ser Ala Leu Arg Arg Phe Ala Leu Ser 
                85                  90                  95      


Ala Met Asp Met Glu Gln Arg Asp Tyr Asp Ser Arg Thr Ala Leu His 
            100                 105                 110         


Val Ala Ala Ala Glu Gly Gly Ile Thr Leu Pro Trp Met Lys His Cys 
        115                 120                 125             


Thr Leu Asp Thr Met Met Tyr Leu Lys Phe Ser Lys Asn Thr Lys Ser 
    130                 135                 140                 


Ser Thr His Leu Lys Glu Ile Leu Thr Thr Gly Arg Lys Ile Lys Pro 
145                 150                 155                 160 


Ser Ile Arg Ile Leu Met Asp Cys Cys Asn Gly Leu Lys Ser Gln Asp 
                165                 170                 175     


Leu Asn His Leu Pro Ile 
            180         


<210>  6038
<211>  114
<212>  PRT
<213>  Homo Sapiens

<400>  6038

Glu Ser Ala Lys Lys Gln Ser Gly Gly Lys Val Ala Asp Tyr Ile Pro 
1               5                   10                  15      


Gln Leu Ala Lys Phe Ser Pro Asp Leu Trp Gly Val Ser Val Cys Thr 
            20                  25                  30          


Val Asp Gly Gln Arg His Ser Thr Gly Asp Thr Lys Val Pro Phe Cys 
        35                  40                  45              


Leu Gln Ser Cys Val Lys Pro Leu Lys Tyr Ala Ile Ala Val Asn Asp 
    50                  55                  60                  


Leu Gly Thr Glu Tyr Val His Arg Tyr Val Gly Lys Glu Pro Ser Gly 
65                  70                  75                  80  


Leu Arg Phe Asn Lys Leu Phe Leu Asn Glu Asp Asp Lys Pro His Asn 
                85                  90                  95      


Pro Met Val Asn Ala Gly Ala Ile Val Val Thr Ser Leu Ile Lys Asp 
            100                 105                 110         


Trp Trp 
        


<210>  6039
<211>  169
<212>  PRT
<213>  Homo Sapiens

<400>  6039

Met Ala Ala Thr Leu Ala Asn Gly Gly Phe Cys Pro Ile Thr Gly Glu 
1               5                   10                  15      


Arg Val Leu Ser Pro Glu Ala Val Arg Asn Thr Leu Ser Leu Met His 
            20                  25                  30          


Ser Cys Gly Met Tyr Asp Phe Ser Gly Gln Phe Ala Phe His Val Gly 
        35                  40                  45              


Leu Pro Ala Lys Ser Gly Val Ala Gly Gly Ile Leu Leu Val Val Pro 
    50                  55                  60                  


Asn Val Met Gly Met Met Cys Trp Ser Pro Pro Leu Asp Lys Met Gly 
65                  70                  75                  80  


Asn Ser Val Lys Gly Ile His Phe Cys His Asp Leu Val Ser Leu Cys 
                85                  90                  95      


Asn Phe His Asn Tyr Asp Asn Leu Arg His Phe Ala Lys Lys Leu Asp 
            100                 105                 110         


Pro Arg Arg Glu Gly Gly Asp Gln Arg His Ser Phe Gly Pro Leu Asp 
        115                 120                 125             


Tyr Glu Ser Leu Gln Gln Glu Leu Ala Leu Lys Glu Thr Val Trp Lys 
    130                 135                 140                 


Lys Val Ser Pro Glu Ser Asn Glu Asp Ile Ser Thr Thr Val Val Tyr 
145                 150                 155                 160 


Arg Met Glu Ser Leu Gly Glu Lys Ser 
                165                 


<210>  6040
<211>  164
<212>  PRT
<213>  Homo Sapiens

<400>  6040

Met Ala Ala Thr Leu Ala Asn Gly Gly Phe Cys Pro Ile Thr Gly Glu 
1               5                   10                  15      


Arg Val Leu Ser Pro Glu Ala Val Arg Asn Thr Leu Ser Leu Met His 
            20                  25                  30          


Ser Cys Gly Met Tyr Asp Phe Ser Gly Gln Phe Ala Phe His Val Gly 
        35                  40                  45              


Leu Pro Ala Lys Ser Gly Val Ala Gly Gly Ile Leu Leu Val Val Pro 
    50                  55                  60                  


Asn Val Met Gly Met Met Cys Trp Ser Pro Pro Leu Asp Lys Met Gly 
65                  70                  75                  80  


Asn Ser Val Lys Gly Ile His Phe Cys His Asp Leu Val Ser Leu Cys 
                85                  90                  95      


Asn Phe His Asn Tyr Asp Asn Leu Arg His Phe Ala Lys Lys Leu Asp 
            100                 105                 110         


Pro Arg Arg Glu Gly Gly Asp Gln Arg Val Lys Ser Val Ile Asn Leu 
        115                 120                 125             


Leu Phe Ala Ala Tyr Thr Gly Asp Val Ser Ala Leu Arg Arg Phe Ala 
    130                 135                 140                 


Leu Ser Ala Met Asp Met Glu Gln Arg Asp Tyr Asp Ser Arg Thr Ala 
145                 150                 155                 160 


Leu His Val Ala 
                


<210>  6041
<211>  103
<212>  PRT
<213>  Homo Sapiens

<400>  6041

Met Gly Met Met Cys Trp Ser Pro Pro Leu Asp Lys Met Gly Asn Ser 
1               5                   10                  15      


Val Lys Gly Ile His Phe Cys His Asp Leu Val Ser Leu Cys Asn Phe 
            20                  25                  30          


His Asn Tyr Asp Asn Leu Arg His Phe Ala Lys Lys Leu Asp Pro Arg 
        35                  40                  45              


Arg Glu Gly Gly Asp Gln Arg His Ser Phe Gly Pro Leu Asp Tyr Glu 
    50                  55                  60                  


Ser Leu Gln Gln Glu Leu Ala Leu Lys Glu Thr Val Trp Lys Lys Val 
65                  70                  75                  80  


Ser Pro Glu Ser Asn Glu Asp Ile Ser Thr Thr Val Val Tyr Arg Met 
                85                  90                  95      


Glu Ser Leu Gly Glu Lys Ser 
            100             


<210>  6042
<211>  174
<212>  PRT
<213>  Homo Sapiens

<400>  6042

Met Gly Met Met Cys Trp Ser Pro Pro Leu Asp Lys Met Gly Asn Ser 
1               5                   10                  15      


Val Lys Gly Ile His Phe Cys His Asp Leu Val Ser Leu Cys Asn Phe 
            20                  25                  30          


His Asn Tyr Asp Asn Leu Arg His Phe Ala Lys Lys Leu Asp Pro Arg 
        35                  40                  45              


Arg Glu Gly Gly Asp Gln Arg Val Lys Ser Val Ile Asn Leu Leu Phe 
    50                  55                  60                  


Ala Ala Tyr Thr Gly Asp Val Ser Ala Leu Arg Arg Phe Ala Leu Ser 
65                  70                  75                  80  


Ala Met Asp Met Glu Gln Arg Asp Tyr Asp Ser Arg Thr Ala Leu His 
                85                  90                  95      


Val Ala Ala Ala Glu Gly His Val Glu Val Val Lys Phe Leu Leu Glu 
            100                 105                 110         


Ala Cys Lys Val Asn Pro Phe Pro Lys Asp Arg Trp Asn Asn Thr Pro 
        115                 120                 125             


Met Asp Glu Ala Leu His Phe Gly His His Asp Val Phe Lys Ile Leu 
    130                 135                 140                 


Gln Glu Tyr Gln Val Gln Tyr Thr Pro Gln Gly Asp Ser Asp Asn Gly 
145                 150                 155                 160 


Lys Glu Asn Gln Thr Val His Lys Asn Leu Asp Gly Leu Leu 
                165                 170                 


<210>  6043
<211>  669
<212>  PRT
<213>  Homo Sapiens

<400>  6043

Met Met Arg Leu Arg Gly Ser Gly Met Leu Arg Asp Leu Leu Leu Arg 
1               5                   10                  15      


Ser Pro Ala Gly Val Ser Ala Thr Leu Arg Arg Ala Gln Pro Leu Val 
            20                  25                  30          


Thr Leu Cys Arg Arg Pro Arg Gly Gly Gly Arg Pro Ala Ala Gly Pro 
        35                  40                  45              


Ala Ala Ala Ala Arg Leu His Pro Trp Trp Gly Gly Gly Gly Trp Pro 
    50                  55                  60                  


Ala Glu Pro Leu Ala Arg Gly Leu Ser Ser Ser Pro Ser Glu Ile Leu 
65                  70                  75                  80  


Gln Glu Leu Gly Lys Gly Ser Thr His Pro Gln Pro Gly Val Ser Pro 
                85                  90                  95      


Pro Ala Ala Pro Ala Ala Pro Gly Pro Lys Asp Gly Pro Gly Glu Thr 
            100                 105                 110         


Asp Ala Phe Gly Asn Ser Glu Gly Lys Glu Leu Val Ala Ser Gly Glu 
        115                 120                 125             


Asn Lys Ile Lys Gln Gly Leu Leu Pro Ser Leu Glu Asp Leu Leu Phe 
    130                 135                 140                 


Tyr Thr Ile Ala Glu Gly Gln Glu Lys Ile Pro Val His Lys Phe Ile 
145                 150                 155                 160 


Thr Ala Leu Lys Ser Thr Gly Leu Arg Thr Ser Asp Pro Arg Leu Lys 
                165                 170                 175     


Glu Cys Met Asp Met Leu Arg Leu Thr Leu Gln Thr Thr Ser Asp Gly 
            180                 185                 190         


Val Met Leu Asp Lys Asp Leu Phe Lys Lys Cys Val Gln Ser Asn Ile 
        195                 200                 205             


Val Leu Leu Thr Gln Ala Phe Arg Arg Lys Phe Val Ile Pro Asp Phe 
    210                 215                 220                 


Met Ser Phe Thr Ser His Ile Asp Glu Leu Tyr Glu Ser Ala Lys Lys 
225                 230                 235                 240 


Gln Ser Gly Gly Lys Val Ala Asp Tyr Ile Pro Gln Leu Ala Lys Phe 
                245                 250                 255     


Ser Pro Asp Leu Trp Gly Val Ser Val Cys Thr Val Asp Gly Gln Arg 
            260                 265                 270         


His Ser Thr Gly Asp Thr Lys Val Pro Phe Cys Leu Gln Ser Cys Val 
        275                 280                 285             


Lys Pro Leu Lys Tyr Ala Ile Ala Val Asn Asp Leu Gly Thr Glu Tyr 
    290                 295                 300                 


Val His Arg Tyr Val Gly Lys Glu Pro Ser Gly Leu Arg Phe Asn Lys 
305                 310                 315                 320 


Leu Phe Leu Asn Glu Asp Asp Lys Pro His Asn Pro Met Val Asn Ala 
                325                 330                 335     


Gly Ala Ile Val Val Thr Ser Leu Ile Lys Gln Gly Val Asn Asn Ala 
            340                 345                 350         


Glu Lys Phe Asp Tyr Val Met Gln Phe Leu Asn Lys Met Ala Gly Asn 
        355                 360                 365             


Glu Tyr Val Gly Phe Ser Asn Ala Thr Phe Gln Ser Glu Arg Glu Ser 
    370                 375                 380                 


Gly Asp Arg Asn Phe Ala Ile Gly Tyr Tyr Leu Lys Glu Lys Lys Cys 
385                 390                 395                 400 


Phe Pro Glu Gly Thr Asp Met Val Gly Ile Leu Asp Phe Tyr Phe Gln 
                405                 410                 415     


Leu Cys Ser Ile Glu Val Thr Cys Glu Ser Ala Ser Val Met Ala Ala 
            420                 425                 430         


Thr Leu Ala Asn Gly Gly Phe Cys Pro Ile Thr Gly Glu Arg Val Leu 
        435                 440                 445             


Ser Pro Glu Ala Val Arg Asn Thr Leu Ser Leu Met His Ser Cys Gly 
    450                 455                 460                 


Met Tyr Asp Phe Ser Gly Gln Phe Ala Phe His Val Gly Leu Pro Ala 
465                 470                 475                 480 


Lys Ser Gly Val Ala Gly Gly Ile Leu Leu Val Val Pro Asn Val Met 
                485                 490                 495     


Gly Met Met Cys Trp Ser Pro Pro Leu Asp Lys Met Gly Asn Ser Val 
            500                 505                 510         


Lys Gly Ile His Phe Cys His Asp Leu Val Ser Leu Cys Asn Phe His 
        515                 520                 525             


Asn Tyr Asp Asn Leu Arg His Phe Ala Lys Lys Leu Asp Pro Arg Arg 
    530                 535                 540                 


Glu Gly Gly Asp Gln Arg Val Lys Ser Val Ile Asn Leu Leu Phe Ala 
545                 550                 555                 560 


Ala Tyr Thr Gly Asp Val Ser Ala Leu Arg Arg Phe Ala Leu Ser Ala 
                565                 570                 575     


Met Asp Met Glu Gln Arg Asp Tyr Asp Ser Arg Thr Ala Leu His Val 
            580                 585                 590         


Ala Ala Ala Glu Gly His Val Glu Val Val Lys Phe Leu Leu Glu Ala 
        595                 600                 605             


Cys Lys Val Asn Pro Phe Pro Lys Asp Arg Trp Asn Asn Thr Pro Met 
    610                 615                 620                 


Asp Glu Ala Leu His Phe Gly His His Asp Val Phe Lys Ile Leu Gln 
625                 630                 635                 640 


Glu Tyr Gln Val Gln Tyr Thr Pro Gln Gly Asp Ser Asp Asn Gly Lys 
                645                 650                 655     


Glu Asn Gln Thr Val His Lys Asn Leu Asp Gly Leu Leu 
            660                 665                 


<210>  6044
<211>  598
<212>  PRT
<213>  Homo Sapiens

<400>  6044

Met Met Arg Leu Arg Gly Ser Gly Met Leu Arg Asp Leu Leu Leu Arg 
1               5                   10                  15      


Ser Pro Ala Gly Val Ser Ala Thr Leu Arg Arg Ala Gln Pro Leu Val 
            20                  25                  30          


Thr Leu Cys Arg Arg Pro Arg Gly Gly Gly Arg Pro Ala Ala Gly Pro 
        35                  40                  45              


Ala Ala Ala Ala Arg Leu His Pro Trp Trp Gly Gly Gly Gly Trp Pro 
    50                  55                  60                  


Ala Glu Pro Leu Ala Arg Gly Leu Ser Ser Ser Pro Ser Glu Ile Leu 
65                  70                  75                  80  


Gln Glu Leu Gly Lys Gly Ser Thr His Pro Gln Pro Gly Val Ser Pro 
                85                  90                  95      


Pro Ala Ala Pro Ala Ala Pro Gly Pro Lys Asp Gly Pro Gly Glu Thr 
            100                 105                 110         


Asp Ala Phe Gly Asn Ser Glu Gly Lys Glu Leu Val Ala Ser Gly Glu 
        115                 120                 125             


Asn Lys Ile Lys Gln Gly Leu Leu Pro Ser Leu Glu Asp Leu Leu Phe 
    130                 135                 140                 


Tyr Thr Ile Ala Glu Gly Gln Glu Lys Ile Pro Val His Lys Phe Ile 
145                 150                 155                 160 


Thr Ala Leu Lys Ser Thr Gly Leu Arg Thr Ser Asp Pro Arg Leu Lys 
                165                 170                 175     


Glu Cys Met Asp Met Leu Arg Leu Thr Leu Gln Thr Thr Ser Asp Gly 
            180                 185                 190         


Val Met Leu Asp Lys Asp Leu Phe Lys Lys Cys Val Gln Ser Asn Ile 
        195                 200                 205             


Val Leu Leu Thr Gln Ala Phe Arg Arg Lys Phe Val Ile Pro Asp Phe 
    210                 215                 220                 


Met Ser Phe Thr Ser His Ile Asp Glu Leu Tyr Glu Ser Ala Lys Lys 
225                 230                 235                 240 


Gln Ser Gly Gly Lys Val Ala Asp Tyr Ile Pro Gln Leu Ala Lys Phe 
                245                 250                 255     


Ser Pro Asp Leu Trp Gly Val Ser Val Cys Thr Val Asp Gly Gln Arg 
            260                 265                 270         


His Ser Thr Gly Asp Thr Lys Val Pro Phe Cys Leu Gln Ser Cys Val 
        275                 280                 285             


Lys Pro Leu Lys Tyr Ala Ile Ala Val Asn Asp Leu Gly Thr Glu Tyr 
    290                 295                 300                 


Val His Arg Tyr Val Gly Lys Glu Pro Ser Gly Leu Arg Phe Asn Lys 
305                 310                 315                 320 


Leu Phe Leu Asn Glu Asp Asp Lys Pro His Asn Pro Met Val Asn Ala 
                325                 330                 335     


Gly Ala Ile Val Val Thr Ser Leu Ile Lys Gln Gly Val Asn Asn Ala 
            340                 345                 350         


Glu Lys Phe Asp Tyr Val Met Gln Phe Leu Asn Lys Met Ala Gly Asn 
        355                 360                 365             


Glu Tyr Val Gly Phe Ser Asn Ala Thr Phe Gln Ser Glu Arg Glu Ser 
    370                 375                 380                 


Gly Asp Arg Asn Phe Ala Ile Gly Tyr Tyr Leu Lys Glu Lys Lys Cys 
385                 390                 395                 400 


Phe Pro Glu Gly Thr Asp Met Val Gly Ile Leu Asp Phe Tyr Phe Gln 
                405                 410                 415     


Leu Cys Ser Ile Glu Val Thr Cys Glu Ser Ala Ser Val Met Ala Ala 
            420                 425                 430         


Thr Leu Ala Asn Gly Gly Phe Cys Pro Ile Thr Gly Glu Arg Val Leu 
        435                 440                 445             


Ser Pro Glu Ala Val Arg Asn Thr Leu Ser Leu Met His Ser Cys Gly 
    450                 455                 460                 


Met Tyr Asp Phe Ser Gly Gln Phe Ala Phe His Val Gly Leu Pro Ala 
465                 470                 475                 480 


Lys Ser Gly Val Ala Gly Gly Ile Leu Leu Val Val Pro Asn Val Met 
                485                 490                 495     


Gly Met Met Cys Trp Ser Pro Pro Leu Asp Lys Met Gly Asn Ser Val 
            500                 505                 510         


Lys Gly Ile His Phe Cys His Asp Leu Val Ser Leu Cys Asn Phe His 
        515                 520                 525             


Asn Tyr Asp Asn Leu Arg His Phe Ala Lys Lys Leu Asp Pro Arg Arg 
    530                 535                 540                 


Glu Gly Gly Asp Gln Arg His Ser Phe Gly Pro Leu Asp Tyr Glu Ser 
545                 550                 555                 560 


Leu Gln Gln Glu Leu Ala Leu Lys Glu Thr Val Trp Lys Lys Val Ser 
                565                 570                 575     


Pro Glu Ser Asn Glu Asp Ile Ser Thr Thr Val Val Tyr Arg Met Glu 
            580                 585                 590         


Ser Leu Gly Glu Lys Ser 
        595             


<210>  6045
<211>  276
<212>  PRT
<213>  Homo Sapiens

<400>  6045

Met Asn Ser Lys Arg Met Leu Leu Leu Val Leu Phe Ala Phe Ser Leu 
1               5                   10                  15      


Met Leu Val Glu Arg Tyr Phe Arg Asn His Gln Val Glu Glu Leu Arg 
            20                  25                  30          


Leu Ser Asp Trp Phe His Pro Arg Lys Arg Pro Asp Val Ile Thr Lys 
        35                  40                  45              


Thr Asp Trp Leu Ala Pro Val Leu Trp Glu Gly Thr Phe Asp Arg Arg 
    50                  55                  60                  


Val Leu Glu Lys His Tyr Arg Arg Arg Asn Ile Thr Val Gly Leu Ala 
65                  70                  75                  80  


Val Phe Ala Thr Gly Arg Phe Ala Glu Glu Tyr Leu Arg Pro Phe Leu 
                85                  90                  95      


His Ser Ala Asn Lys His Phe Met Thr Gly Tyr Arg Val Ile Phe Tyr 
            100                 105                 110         


Ile Met Val Asp Ala Phe Phe Lys Leu Pro Asp Ile Glu Pro Ser Pro 
        115                 120                 125             


Leu Arg Thr Phe Lys Ala Phe Lys Val Gly Thr Glu Arg Trp Trp Leu 
    130                 135                 140                 


Asp Gly Pro Leu Val His Val Lys Ser Leu Gly Glu His Ile Ala Ser 
145                 150                 155                 160 


His Ile Gln Asp Glu Val Asp Phe Leu Phe Ser Met Ala Ala Asn Gln 
                165                 170                 175     


Val Phe Gln Asn Glu Phe Gly Val Glu Thr Leu Gly Pro Leu Val Ala 
            180                 185                 190         


Gln Leu His Ala Trp Trp Tyr Phe Arg Asn Thr Lys Asn Phe Pro Tyr 
        195                 200                 205             


Glu Arg Arg Pro Thr Ser Ala Ala Cys Ile Pro Phe Gly Gln Gly Asp 
    210                 215                 220                 


Phe Tyr Tyr Gly Asn Leu Met Val Gly Gly Thr Pro His Asn Ile Leu 
225                 230                 235                 240 


Asp Phe Ile Lys Glu Tyr Leu Asn Gly Val Ile His Asp Ile Lys Asn 
                245                 250                 255     


Gly Leu Asn Ser Thr Tyr Glu Lys His Leu Asn Lys Tyr Phe Tyr Leu 
            260                 265                 270         


Asn Lys Pro Thr 
        275     


<210>  6046
<211>  307
<212>  PRT
<213>  Homo Sapiens

<400>  6046

Met Asn Ser Lys Arg Met Leu Leu Leu Val Leu Phe Ala Phe Ser Leu 
1               5                   10                  15      


Met Leu Val Glu Arg Tyr Phe Arg Asn His Gln Val Glu Glu Leu Arg 
            20                  25                  30          


Leu Ser Asp Trp Phe His Pro Arg Lys Arg Pro Asp Val Ile Thr Lys 
        35                  40                  45              


Thr Asp Trp Leu Ala Pro Val Leu Trp Glu Gly Thr Phe Asp Arg Arg 
    50                  55                  60                  


Val Leu Glu Lys His Tyr Arg Arg Arg Asn Ile Thr Val Gly Leu Ala 
65                  70                  75                  80  


Val Phe Ala Thr Gly Arg Phe Ala Glu Glu Tyr Leu Arg Pro Phe Leu 
                85                  90                  95      


His Ser Ala Asn Lys His Phe Met Thr Gly Tyr Arg Val Ile Phe Tyr 
            100                 105                 110         


Ile Met Val Asp Ala Phe Phe Lys Leu Pro Asp Ile Glu Pro Ser Pro 
        115                 120                 125             


Leu Arg Thr Phe Lys Ala Phe Lys Val Gly Thr Glu Arg Trp Trp Leu 
    130                 135                 140                 


Asp Gly Pro Leu Val His Val Lys Ser Leu Gly Glu His Ile Ala Ser 
145                 150                 155                 160 


His Ile Gln Asp Glu Val Asp Phe Leu Phe Ser Met Ala Ala Asn Gln 
                165                 170                 175     


Val Phe Gln Asn Glu Phe Gly Val Glu Thr Leu Gly Pro Leu Val Ala 
            180                 185                 190         


Gln Leu His Ala Trp Trp Tyr Phe Arg Asn Thr Lys Asn Phe Pro Tyr 
        195                 200                 205             


Glu Arg Arg Pro Thr Ser Ala Ala Cys Ile Pro Phe Gly Gln Gly Asp 
    210                 215                 220                 


Phe Tyr Tyr Gly Asn Leu Met Val Gly Gly Thr Pro His Asn Ile Leu 
225                 230                 235                 240 


Asp Phe Ile Lys Glu Tyr Leu Asn Gly Val Ile His Asp Ile Lys Asn 
                245                 250                 255     


Gly Leu Asn Ser Thr Tyr Glu Lys His Leu Asn Lys Tyr Phe Tyr Leu 
            260                 265                 270         


Asn Lys Pro Thr Leu Leu Ser Pro Ala Tyr Ser Trp Asp Leu Ala Phe 
        275                 280                 285             


Ser Pro Pro Pro Gln Ile Gln Tyr Val Lys Val Ala His Asp Ser Gln 
    290                 295                 300                 


Arg Lys Leu 
305         


<210>  6047
<211>  291
<212>  PRT
<213>  Homo Sapiens

<400>  6047

Met Gly Val Ala Ala Arg Pro Pro Ala Leu Arg His Trp Phe Ser His 
1               5                   10                  15      


Ser Ile Pro Leu Ala Ile Phe Ala Leu Leu Leu Leu Tyr Leu Ser Val 
            20                  25                  30          


Arg Ser Leu Gly Ala Arg Ser Gly Cys Gly Pro Arg Ala Gln Pro Cys 
        35                  40                  45              


Val Pro Gly Glu Thr Ala Pro Phe Gln Val Arg Gln Glu Ser Gly Thr 
    50                  55                  60                  


Leu Glu Ala Pro Glu Arg Lys Gln Pro Pro Cys Leu Gly Pro Arg Gly 
65                  70                  75                  80  


Met Leu Gly Arg Met Met Arg Arg Phe His Ala Ser Leu Lys Pro Glu 
                85                  90                  95      


Gly Asp Val Gly Leu Ser Pro Tyr Leu Ala Gly Trp Arg Ala Leu Val 
            100                 105                 110         


Glu Phe Leu Thr Pro Leu Gly Ser Val Phe Ala Phe Ala Thr Arg Glu 
        115                 120                 125             


Ala Phe Thr Lys Val Thr Asp Leu Glu Ala Arg Val His Gly Pro Asp 
    130                 135                 140                 


Ala Glu His Tyr Trp Ser Leu Val Ala Met Ala Ala Trp Glu Arg Arg 
145                 150                 155                 160 


Ala Gly Leu Leu Glu Gln Pro Gly Ala Ala Pro Arg Asp Pro Thr Arg 
                165                 170                 175     


Ser Ser Gly Ser Arg Thr Leu Leu Leu Leu His Arg Ala Leu Arg Trp 
            180                 185                 190         


Ser Gln Leu Cys Leu His Arg Val Ala Thr Gly Ala Leu Gly Gly Pro 
        195                 200                 205             


Asp Ala Gly Val Gln Cys Ser Asp Ala Tyr Arg Ala Ala Leu Gly Pro 
    210                 215                 220                 


His His Pro Trp Leu Val Arg Gln Thr Ala Arg Leu Ala Phe Leu Ala 
225                 230                 235                 240 


Phe Pro Gly Arg Arg Arg Leu Leu Glu Leu Ala Cys Pro Gly Ala Thr 
                245                 250                 255     


Glu Ala Glu Ala Arg Ala Ala Leu Val Arg Ala Ala Gly Thr Leu Glu 
            260                 265                 270         


Asp Val Tyr Asn Arg Thr Gln Ser Leu Leu Ala Glu Arg Gly Leu Leu 
        275                 280                 285             


Gln Leu Ala 
    290     


<210>  6048
<211>  558
<212>  PRT
<213>  Homo Sapiens

<400>  6048

Met Tyr Arg Tyr Leu Gly Glu Ala Leu Leu Leu Ser Arg Ala Gly Pro 
1               5                   10                  15      


Ala Ala Leu Gly Ser Ala Ser Ala Asp Ser Ala Ala Leu Leu Gly Trp 
            20                  25                  30          


Ala Arg Gly Gln Pro Ala Ala Ala Pro Gln Pro Gly Leu Ala Leu Ala 
        35                  40                  45              


Ala Arg Arg His Tyr Ser Glu Ala Val Ala Asp Arg Glu Asp Asp Pro 
    50                  55                  60                  


Asn Phe Phe Lys Met Val Glu Gly Phe Phe Asp Arg Gly Ala Ser Ile 
65                  70                  75                  80  


Val Glu Asp Lys Leu Val Glu Asp Leu Arg Thr Arg Glu Ser Glu Glu 
                85                  90                  95      


Gln Lys Arg Asn Arg Val Arg Gly Ile Leu Arg Ile Ile Lys Pro Cys 
            100                 105                 110         


Asn His Val Leu Ser Leu Ser Phe Pro Ile Arg Arg Asp Asp Gly Ser 
        115                 120                 125             


Trp Glu Val Ile Glu Gly Tyr Arg Ala Gln His Ser Gln His Arg Thr 
    130                 135                 140                 


Pro Cys Lys Gly Gly Ile Arg Tyr Ser Thr Asp Val Ser Val Asp Glu 
145                 150                 155                 160 


Val Lys Ala Leu Ala Ser Leu Met Thr Tyr Lys Cys Ala Val Val Asp 
                165                 170                 175     


Val Pro Phe Gly Gly Ala Lys Ala Gly Val Lys Ile Asn Pro Lys Asn 
            180                 185                 190         


Tyr Thr Asp Asn Glu Leu Glu Lys Ile Thr Arg Arg Phe Thr Met Glu 
        195                 200                 205             


Leu Ala Lys Lys Gly Phe Ile Gly Pro Gly Ile Asp Val Pro Ala Pro 
    210                 215                 220                 


Asp Met Ser Thr Gly Glu Arg Glu Met Ser Trp Ile Ala Asp Thr Tyr 
225                 230                 235                 240 


Ala Ser Thr Ile Gly His Tyr Asp Ile Asn Ala His Ala Cys Val Thr 
                245                 250                 255     


Gly Lys Pro Ile Ser Gln Gly Gly Ile His Gly Arg Ile Ser Ala Thr 
            260                 265                 270         


Gly Arg Gly Val Phe His Gly Ile Glu Asn Phe Ile Asn Glu Ala Ser 
        275                 280                 285             


Tyr Met Ser Ile Leu Gly Met Thr Pro Gly Phe Gly Asp Lys Thr Phe 
    290                 295                 300                 


Val Val Gln Gly Phe Gly Asn Val Gly Leu His Ser Met Arg Tyr Leu 
305                 310                 315                 320 


His Arg Phe Gly Ala Lys Cys Ile Ala Val Gly Glu Ser Asp Gly Ser 
                325                 330                 335     


Ile Trp Asn Pro Asp Gly Ile Asp Pro Lys Glu Leu Glu Asp Phe Lys 
            340                 345                 350         


Leu Gln His Gly Ser Ile Leu Gly Phe Pro Lys Ala Lys Pro Tyr Glu 
        355                 360                 365             


Gly Ser Ile Leu Glu Ala Asp Cys Asp Ile Leu Ile Pro Ala Ala Ser 
    370                 375                 380                 


Glu Lys Gln Leu Thr Lys Ser Asn Ala Pro Arg Val Lys Ala Lys Ile 
385                 390                 395                 400 


Ile Ala Glu Gly Ala Asn Gly Pro Thr Thr Pro Glu Ala Asp Lys Ile 
                405                 410                 415     


Phe Leu Glu Arg Asn Ile Met Val Ile Pro Asp Leu Tyr Leu Asn Ala 
            420                 425                 430         


Gly Gly Val Thr Val Ser Tyr Phe Glu Trp Leu Lys Asn Leu Asn His 
        435                 440                 445             


Val Ser Tyr Gly Arg Leu Thr Phe Lys Tyr Glu Arg Asp Ser Asn Tyr 
    450                 455                 460                 


His Leu Leu Met Ser Val Gln Glu Ser Leu Glu Arg Lys Phe Gly Lys 
465                 470                 475                 480 


His Gly Gly Thr Ile Pro Ile Val Pro Thr Ala Glu Phe Gln Asp Arg 
                485                 490                 495     


Ile Ser Gly Ala Ser Glu Lys Asp Ile Val His Ser Gly Leu Ala Tyr 
            500                 505                 510         


Thr Met Glu Arg Ser Ala Arg Gln Ile Met Arg Thr Ala Met Lys Tyr 
        515                 520                 525             


Asn Leu Gly Leu Asp Leu Arg Thr Ala Ala Tyr Val Asn Ala Ile Glu 
    530                 535                 540                 


Lys Val Phe Lys Val Tyr Asn Glu Ala Gly Val Thr Phe Thr 
545                 550                 555             


<210>  6049
<211>  193
<212>  PRT
<213>  Homo Sapiens

<400>  6049

Met Gln Ser Leu Met Gln Ala Pro Leu Leu Ile Ala Leu Gly Leu Leu 
1               5                   10                  15      


Leu Ala Ala Pro Ala Gln Ala His Leu Lys Lys Pro Ser Gln Leu Ser 
            20                  25                  30          


Ser Phe Ser Trp Asp Asn Cys Asp Glu Gly Lys Asp Pro Ala Val Ile 
        35                  40                  45              


Arg Ser Leu Thr Leu Glu Pro Asp Pro Ile Ile Val Pro Gly Asn Val 
    50                  55                  60                  


Thr Leu Ser Val Met Gly Ser Thr Ser Val Pro Leu Ser Ser Pro Leu 
65                  70                  75                  80  


Lys Val Asp Leu Val Leu Glu Lys Glu Val Ala Gly Leu Trp Ile Lys 
                85                  90                  95      


Ile Pro Cys Thr Asp Tyr Ile Gly Ser Cys Thr Phe Glu His Phe Cys 
            100                 105                 110         


Asp Val Leu Asp Met Leu Ile Pro Thr Gly Glu Pro Cys Pro Glu Pro 
        115                 120                 125             


Leu Arg Thr Tyr Gly Leu Pro Cys His Cys Pro Phe Lys Glu Gly Thr 
    130                 135                 140                 


Tyr Ser Leu Pro Lys Ser Glu Phe Val Val Pro Asp Leu Glu Leu Pro 
145                 150                 155                 160 


Ser Trp Leu Thr Thr Gly Asn Tyr Arg Ile Glu Ser Val Leu Ser Ser 
                165                 170                 175     


Ser Gly Lys Arg Leu Gly Cys Ile Lys Ile Ala Ala Ser Leu Lys Gly 
            180                 185                 190         


Ile 
    


<210>  6050
<211>  146
<212>  PRT
<213>  Homo Sapiens

<400>  6050

Met Ser Trp Val Glu Ala Ala Gly Val Ser Ser Thr Ala Leu Glu Asp 
1               5                   10                  15      


Arg Ile Val Ala Lys His Glu Glu Val Pro Glu Val Ser Val Gln Tyr 
            20                  25                  30          


Glu Glu Lys Phe Gln Asn His His Lys Leu Pro Ser Gln Leu Ser Ser 
        35                  40                  45              


Phe Ser Trp Asp Asn Cys Asp Glu Gly Lys Asp Pro Ala Val Ile Arg 
    50                  55                  60                  


Ser Leu Thr Leu Glu Pro Asp Pro Ile Ile Val Pro Gly Asn Val Thr 
65                  70                  75                  80  


Leu Ser Val Met Gly Ser Thr Ser Val Pro Leu Ser Ser Pro Leu Lys 
                85                  90                  95      


Val Asp Leu Val Leu Glu Lys Glu Val Ala Gly Leu Trp Ile Lys Ile 
            100                 105                 110         


Pro Cys Thr Asp Tyr Ile Gly Ser Cys Thr Phe Glu His Phe Cys Asp 
        115                 120                 125             


Val Leu Asp Met Leu Ile Pro Thr Gly Glu Pro Cys Pro Glu Pro Leu 
    130                 135                 140                 


Arg Thr 
145     


<210>  6051
<211>  104
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6051

Xaa Lys Asp Pro Ala Val Ile Arg Ser Leu Thr Leu Glu Pro Asp Pro 
1               5                   10                  15      


Ile Ile Val Pro Gly Asn Val Thr Leu Ser Val Met Gly Ser Thr Ser 
            20                  25                  30          


Val Pro Leu Ser Ser Pro Leu Lys Val Asp Leu Val Leu Glu Lys Glu 
        35                  40                  45              


Val Ala Gly Leu Trp Ile Lys Ile Pro Cys Thr Asp Tyr Ile Gly Ser 
    50                  55                  60                  


Cys Thr Phe Glu His Phe Cys Asp Val Leu Asp Met Leu Ile Pro Thr 
65                  70                  75                  80  


Gly Glu Pro Cys Pro Glu Pro Leu Arg Thr Tyr Gly Leu Pro Cys His 
                85                  90                  95      


Cys Pro Phe Lys Glu Val Ser Thr 
            100                 


<210>  6052
<211>  118
<212>  PRT
<213>  Homo Sapiens

<400>  6052

Met Leu Leu Phe Ala Leu Leu Leu Ala Met Glu Leu Pro Leu Val Ala 
1               5                   10                  15      


Ala Ser Ala Thr Met Arg Ala Gln Trp Thr Tyr Ser Leu Arg Cys His 
            20                  25                  30          


Asp Cys Ala Val Ile Asn Asp Phe Asn Cys Pro Asn Ile Arg Val Cys 
        35                  40                  45              


Pro Tyr His Ile Arg Arg Cys Met Thr Ile Ser Ile Gln Leu Ser Ser 
    50                  55                  60                  


Gly Asp Arg Ala Ala Val Cys Pro Gly Pro His Pro Thr Phe Phe Gln 
65                  70                  75                  80  


Pro Gly Ala Trp Ile Pro Thr Gln Val Thr Asp Ser Lys His Gln Pro 
                85                  90                  95      


Leu Pro Ala His Leu Thr Arg Arg His Pro Leu His Gly Pro Gly Asn 
            100                 105                 110         


Ile Leu Pro Ser Ala Ile 
        115             


<210>  6053
<211>  158
<212>  PRT
<213>  Homo Sapiens

<400>  6053

Met Leu Leu Phe Ala Leu Leu Leu Ala Met Glu Leu Pro Leu Val Ala 
1               5                   10                  15      


Ala Ser Ala Thr Met Arg Ala Gln Trp Thr Tyr Ser Leu Arg Cys His 
            20                  25                  30          


Asp Cys Ala Val Ile Asn Asp Phe Asn Cys Pro Asn Ile Arg Val Cys 
        35                  40                  45              


Pro Tyr His Ile Arg Arg Cys Met Thr Ile Ser Ile Arg Ile Asn Ser 
    50                  55                  60                  


Arg Glu Leu Leu Val Tyr Lys Asn Cys Thr Asn Asn Cys Thr Phe Val 
65                  70                  75                  80  


Tyr Ala Ala Glu Gln Pro Pro Glu Ala Pro Gly Lys Ile Phe Lys Thr 
                85                  90                  95      


Asn Ser Phe Tyr Trp Val Cys Cys Cys Asn Ser Met Val Cys Asn Ala 
            100                 105                 110         


Gly Gly Pro Thr Asn Leu Glu Arg Asp Met Leu Pro Asp Glu Val Thr 
        115                 120                 125             


Glu Glu Glu Leu Pro Glu Gly Thr Val Arg Leu Gly Val Ser Lys Leu 
    130                 135                 140                 


Leu Leu Ser Phe Ala Ser Ile Ile Val Ser Asn Ile Leu Pro 
145                 150                 155             


<210>  6054
<211>  625
<212>  PRT
<213>  Homo Sapiens

<400>  6054

Met Ala Arg Pro Val Asp Pro Gln Arg Ser Pro Asp Pro Thr Phe Arg 
1               5                   10                  15      


Ser Ser Thr Arg His Ser Gly Lys Leu Glu Pro Met Glu Ala Thr Ala 
            20                  25                  30          


His Leu Leu Arg Lys Gln Cys Pro Ser Arg Leu Asn Ser Pro Ala Trp 
        35                  40                  45              


Glu Ala Ser Gly Leu His Trp Ser Ser Leu Asp Ser Pro Val Gly Ser 
    50                  55                  60                  


Met Gln Ala Leu Arg Pro Ser Ala Gln His Ser Trp Ser Pro Glu Pro 
65                  70                  75                  80  


Ser Val Val Pro Asp Gln Ala Trp Glu Asp Thr Ala Leu His Gln Lys 
                85                  90                  95      


Lys Leu Cys Pro Leu Ser Leu Thr Ser Leu Pro Arg Glu Ala Ala Val 
            100                 105                 110         


Asn Phe Ser Tyr Arg Ser Gln Thr Leu Leu Gln Glu Ala Gln Val Leu 
        115                 120                 125             


Gln Gly Ser Pro Glu Leu Leu Pro Arg Ser Pro Lys Pro Ser Gly Leu 
    130                 135                 140                 


Gln Arg Leu Ala Pro Glu Glu Ala Thr Ala Leu Pro Leu Arg Arg Leu 
145                 150                 155                 160 


Cys His Leu Ser Leu Met Glu Lys Asp Leu Gly Thr Thr Ala His Pro 
                165                 170                 175     


Arg Gly Phe Pro Glu Leu Ser His Lys Ser Thr Ala Ala Ala Ser Ser 
            180                 185                 190         


Arg Gln Ser Arg Pro Arg Val Arg Ser Ala Ser Leu Pro Pro Arg Thr 
        195                 200                 205             


Arg Leu Pro Ser Gly Ser Gln Ala Pro Ser Ala Ala His Pro Lys Arg 
    210                 215                 220                 


Leu Ser Asp Leu Leu Leu Thr Ser Arg Ala Ala Ala Pro Gly Trp Arg 
225                 230                 235                 240 


Ser Pro Asp Pro Arg Ser Arg Leu Ala Ala Pro Pro Leu Gly Ser Thr 
                245                 250                 255     


Thr Leu Pro Ser Thr Trp Thr Ala Pro Gln Ser Arg Leu Thr Ala Arg 
            260                 265                 270         


Pro Ser Arg Ser Pro Glu Pro Gln Ile Arg Glu Ser Glu Gln Arg Asp 
        275                 280                 285             


Pro Gln Leu Arg Arg Lys Gln Gln Arg Trp Lys Glu Pro Leu Met Pro 
    290                 295                 300                 


Arg Arg Glu Glu Lys Tyr Pro Leu Arg Gly Thr Asp Pro Leu Pro Pro 
305                 310                 315                 320 


Gly Gln Pro Gln Arg Ile Pro Leu Pro Gly Gln Pro Leu Gln Pro Gln 
                325                 330                 335     


Pro Ile Leu Thr Pro Gly Gln Pro Gln Lys Ile Pro Thr Pro Gly Gln 
            340                 345                 350         


His Gln Pro Ile Leu Thr Pro Gly His Ser Gln Pro Ile Pro Thr Pro 
        355                 360                 365             


Gly Gln Pro Leu Pro Pro Gln Pro Ile Pro Thr Pro Gly Arg Pro Leu 
    370                 375                 380                 


Thr Pro Gln Pro Ile Pro Thr Pro Gly Arg Pro Leu Thr Pro Gln Pro 
385                 390                 395                 400 


Ile Gln Met Pro Gly Arg Pro Leu Arg Leu Pro Pro Pro Leu Arg Leu 
                405                 410                 415     


Leu Arg Pro Gly Gln Pro Met Ser Pro Gln Leu Arg Gln Thr Gln Gly 
            420                 425                 430         


Leu Pro Leu Pro Gln Pro Leu Leu Pro Pro Gly Gln Pro Lys Ser Ala 
        435                 440                 445             


Gly Arg Pro Leu Gln Pro Leu Pro Pro Gly Pro Asp Ala Arg Ser Ile 
    450                 455                 460                 


Ser Asp Pro Pro Ala Pro Arg Ser Arg Leu Pro Ile Arg Leu Leu Arg 
465                 470                 475                 480 


Gly Leu Leu Ala Arg Leu Pro Gly Gly Ala Ser Pro Arg Ala Ala Ala 
                485                 490                 495     


Ala Ala Ala Cys Thr Thr Met Lys Gly Trp Pro Ala Ala Thr Met Thr 
            500                 505                 510         


Pro Ala Glu Thr Ser Pro Thr Met Gly Pro Pro Asp Ala Ser Ala Gly 
        515                 520                 525             


Phe Ser Ile Gly Glu Ile Ala Ala Ala Glu Ser Pro Ser Ala Thr Tyr 
    530                 535                 540                 


Ser Ala Thr Phe Ser Cys Lys Pro Ser Gly Ala Ala Ser Val Asp Leu 
545                 550                 555                 560 


Arg Val Pro Ser Pro Lys Pro Arg Ala Leu Ser Arg Ser Arg Arg Tyr 
                565                 570                 575     


Pro Trp Arg Arg Ser Ala Asp Arg Cys Ala Lys Lys Pro Trp Arg Ser 
            580                 585                 590         


Gly Pro Arg Ser Ala Gln Arg Arg Asn Ala Val Ser Ser Ser Thr Asn 
        595                 600                 605             


Asn Ser Arg Thr Lys Arg Trp Ala Thr Cys Val Arg Thr Ala Cys Cys 
    610                 615                 620                 


Phe 
625 


<210>  6055
<211>  245
<212>  PRT
<213>  Homo Sapiens

<400>  6055

Met Asp Arg Arg Ser Arg Ala Gln Gln Trp Arg Arg Ala Arg His Asn 
1               5                   10                  15      


Tyr Asn Asp Leu Cys Pro Pro Ile Gly Arg Arg Ala Ala Thr Ala Leu 
            20                  25                  30          


Leu Trp Leu Ser Cys Ser Ile Ala Leu Leu Arg Ala Leu Ala Thr Ser 
        35                  40                  45              


Asn Ala Arg Ala Gln Gln Arg Ala Ala Ala Gln Gln Arg Arg Ser Phe 
    50                  55                  60                  


Leu Asn Ala His His Arg Ser Gly Ala Gln Val Phe Pro Glu Ser Pro 
65                  70                  75                  80  


Glu Ser Glu Ser Asp His Glu His Glu Glu Ala Asp Leu Glu Leu Ser 
                85                  90                  95      


Leu Pro Glu Cys Leu Glu Tyr Glu Glu Glu Phe Asp Tyr Glu Thr Glu 
            100                 105                 110         


Ser Glu Thr Glu Ser Glu Ile Glu Ser Glu Thr Asp Phe Glu Thr Glu 
        115                 120                 125             


Pro Glu Thr Ala Pro Thr Thr Glu Pro Glu Thr Glu Pro Glu Asp Asp 
    130                 135                 140                 


Arg Gly Pro Val Val Pro Lys His Ser Thr Phe Gly Gln Ser Leu Thr 
145                 150                 155                 160 


Gln Arg Leu His Ala Leu Lys Leu Arg Ser Pro Asp Ala Ser Pro Ser 
                165                 170                 175     


Arg Ala Pro Pro Ser Thr Gln Glu Pro Gln Ser Pro Arg Glu Gly Glu 
            180                 185                 190         


Glu Leu Lys Pro Glu Asp Lys Asp Pro Arg Asp Pro Glu Glu Ser Lys 
        195                 200                 205             


Glu Pro Lys Glu Glu Lys Gln Arg Arg Arg Cys Lys Pro Lys Lys Pro 
    210                 215                 220                 


Thr Arg Arg Asp Ala Ser Pro Glu Ser Pro Ser Lys Lys Gly Pro Ile 
225                 230                 235                 240 


Pro Ile Arg Arg His 
                245 


<210>  6056
<211>  245
<212>  PRT
<213>  Homo Sapiens

<400>  6056

Met Asp Arg Arg Ser Arg Ala Gln Gln Trp Arg Arg Ala Arg His Asn 
1               5                   10                  15      


Tyr Asn Asp Leu Cys Pro Pro Ile Gly Arg Arg Ala Ala Thr Ala Leu 
            20                  25                  30          


Leu Trp Leu Ser Cys Ser Ile Ala Leu Leu Arg Ala Leu Ala Thr Ser 
        35                  40                  45              


Asn Ala Arg Ala Gln Gln Arg Ala Ala Ala Gln Gln Arg Arg Ser Phe 
    50                  55                  60                  


Leu Asn Ala His His Arg Ser Gly Ala Gln Val Phe Pro Glu Ser Pro 
65                  70                  75                  80  


Glu Ser Glu Ser Asp His Glu His Glu Glu Ala Asp Leu Glu Leu Ser 
                85                  90                  95      


Leu Pro Glu Cys Leu Glu Tyr Glu Glu Glu Phe Asp Tyr Glu Thr Glu 
            100                 105                 110         


Ser Glu Thr Glu Ser Glu Ile Glu Ser Glu Thr Asp Phe Glu Thr Glu 
        115                 120                 125             


Pro Glu Thr Ala Pro Thr Thr Glu Pro Glu Thr Glu Pro Glu Asp Asp 
    130                 135                 140                 


Arg Gly Pro Val Val Pro Lys His Ser Thr Phe Gly Gln Ser Leu Thr 
145                 150                 155                 160 


Gln Arg Leu His Ala Leu Lys Leu Arg Ser Pro Asp Ala Ser Pro Ser 
                165                 170                 175     


Arg Ala Pro Pro Ser Thr Gln Glu Pro Gln Ser Pro Arg Glu Gly Glu 
            180                 185                 190         


Glu Leu Lys Pro Glu Asp Lys Asp Pro Arg Asp Pro Glu Glu Ser Lys 
        195                 200                 205             


Glu Pro Lys Glu Glu Lys Gln Arg Arg Arg Cys Lys Pro Lys Lys Pro 
    210                 215                 220                 


Thr Arg Arg Asp Ala Ser Pro Glu Ser Pro Ser Lys Lys Gly Pro Ile 
225                 230                 235                 240 


Pro Ile Arg Arg His 
                245 


<210>  6057
<211>  245
<212>  PRT
<213>  Homo Sapiens

<400>  6057

Met Asp Arg Arg Ser Arg Ala Gln Gln Trp Arg Arg Ala Arg His Asn 
1               5                   10                  15      


Tyr Asn Asp Leu Cys Pro Pro Ile Gly Arg Arg Ala Ala Thr Ala Leu 
            20                  25                  30          


Leu Trp Leu Ser Cys Ser Ile Ala Leu Leu Arg Ala Leu Ala Thr Ser 
        35                  40                  45              


Asn Ala Arg Ala Gln Gln Arg Ala Ala Ala Gln Gln Arg Arg Ser Phe 
    50                  55                  60                  


Leu Asn Ala His His Arg Ser Gly Ala Gln Val Phe Pro Glu Ser Pro 
65                  70                  75                  80  


Glu Ser Glu Ser Asp His Glu His Glu Glu Ala Asp Leu Glu Leu Ser 
                85                  90                  95      


Leu Pro Glu Cys Leu Glu Tyr Glu Glu Glu Phe Asp Tyr Glu Thr Glu 
            100                 105                 110         


Ser Glu Thr Glu Ser Glu Ile Glu Ser Glu Thr Asp Phe Glu Thr Glu 
        115                 120                 125             


Pro Glu Thr Ala Pro Thr Thr Glu Pro Glu Thr Glu Pro Glu Asp Asp 
    130                 135                 140                 


Arg Gly Pro Val Val Pro Lys His Ser Thr Phe Gly Gln Ser Leu Thr 
145                 150                 155                 160 


Gln Arg Leu His Ala Leu Lys Leu Arg Ser Pro Asp Ala Ser Pro Ser 
                165                 170                 175     


Arg Ala Pro Pro Ser Thr Gln Glu Pro Gln Ser Pro Arg Glu Gly Glu 
            180                 185                 190         


Glu Leu Lys Pro Glu Asp Lys Asp Pro Arg Asp Pro Glu Glu Ser Lys 
        195                 200                 205             


Glu Pro Lys Glu Glu Lys Gln Arg Arg Arg Cys Lys Pro Lys Lys Pro 
    210                 215                 220                 


Thr Arg Arg Asp Ala Ser Pro Glu Ser Pro Ser Lys Lys Gly Pro Ile 
225                 230                 235                 240 


Pro Ile Arg Arg His 
                245 


<210>  6058
<211>  158
<212>  PRT
<213>  Homo Sapiens

<400>  6058

Met Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp Gln Arg Asn Glu Glu 
1               5                   10                  15      


Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu Gln Glu 
            20                  25                  30          


Ala Leu Asn Leu Phe Lys Ser Ile Trp Asn Asn Arg Trp Leu Arg Thr 
        35                  40                  45              


Ile Ser Val Ile Leu Phe Leu Asn Lys Gln Asp Leu Leu Ala Glu Lys 
    50                  55                  60                  


Val Leu Ala Gly Lys Ser Lys Ile Glu Asp Tyr Phe Pro Glu Phe Ala 
65                  70                  75                  80  


Arg Tyr Thr Thr Pro Glu Asp Ala Thr Pro Glu Pro Gly Glu Asp Pro 
                85                  90                  95      


Arg Val Thr Arg Ala Lys Tyr Phe Ile Arg Asp Glu Phe Leu Arg Ile 
            100                 105                 110         


Ser Thr Ala Ser Gly Asp Gly Arg His Tyr Cys Tyr Pro His Phe Thr 
        115                 120                 125             


Cys Ala Val Asp Thr Glu Asn Ile Arg Arg Val Phe Asn Asp Cys Arg 
    130                 135                 140                 


Asp Ile Ile Gln Arg Met His Leu Arg Gln Tyr Glu Leu Leu 
145                 150                 155             


<210>  6059
<211>  379
<212>  PRT
<213>  Homo Sapiens

<400>  6059

Met Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp Gln Arg Asn Glu Glu 
1               5                   10                  15      


Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu Gln Lys 
            20                  25                  30          


Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu Leu Leu Leu Gly Ala 
        35                  40                  45              


Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu His 
    50                  55                  60                  


Val Asn Gly Phe Asn Gly Asp Glu Lys Ala Thr Lys Val Gln Asp Ile 
65                  70                  75                  80  


Lys Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala Ala Met Ser 
                85                  90                  95      


Asn Leu Val Pro Pro Val Glu Leu Ala Asn Pro Glu Asn Gln Phe Arg 
            100                 105                 110         


Val Asp Tyr Ile Leu Ser Val Met Asn Val Pro Asp Phe Asp Phe Pro 
        115                 120                 125             


Pro Glu Phe Tyr Glu His Ala Lys Ala Leu Trp Glu Asp Glu Gly Val 
    130                 135                 140                 


Arg Ala Cys Tyr Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp Cys Ala 
145                 150                 155                 160 


Gln Tyr Phe Leu Asp Lys Ile Asp Val Ile Lys Gln Ala Asp Tyr Val 
                165                 170                 175     


Pro Ser Asp Gln Asp Leu Leu Arg Cys Arg Val Leu Thr Ser Gly Ile 
            180                 185                 190         


Phe Glu Thr Lys Phe Gln Val Asp Lys Val Asn Phe His Met Phe Asp 
        195                 200                 205             


Val Gly Gly Gln Arg Asp Glu Arg Arg Lys Trp Ile Gln Cys Phe Asn 
    210                 215                 220                 


Asp Val Thr Ala Ile Ile Phe Val Val Ala Ser Ser Ser Tyr Asn Met 
225                 230                 235                 240 


Val Ile Arg Glu Asp Asn Gln Thr Asn Arg Leu Gln Glu Ala Leu Asn 
                245                 250                 255     


Leu Phe Lys Ser Ile Trp Asn Asn Arg Trp Leu Arg Thr Ile Ser Val 
            260                 265                 270         


Ile Leu Phe Leu Asn Lys Gln Asp Leu Leu Ala Glu Lys Val Leu Ala 
        275                 280                 285             


Gly Lys Ser Lys Ile Glu Asp Tyr Phe Pro Glu Phe Ala Arg Tyr Thr 
    290                 295                 300                 


Thr Pro Glu Asp Ala Thr Pro Glu Pro Gly Glu Asp Pro Arg Val Thr 
305                 310                 315                 320 


Arg Ala Lys Tyr Phe Ile Arg Asp Glu Phe Leu Arg Ile Ser Thr Ala 
                325                 330                 335     


Ser Gly Asp Gly Arg His Tyr Cys Tyr Pro His Phe Thr Cys Ala Val 
            340                 345                 350         


Asp Thr Glu Asn Ile Arg Arg Val Phe Asn Asp Cys Arg Asp Ile Ile 
        355                 360                 365             


Gln Arg Met His Leu Arg Gln Tyr Glu Leu Leu 
    370                 375                 


<210>  6060
<211>  380
<212>  PRT
<213>  Homo Sapiens

<400>  6060

Met Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp Gln Arg Asn Glu Glu 
1               5                   10                  15      


Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu Gln Lys 
            20                  25                  30          


Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu Leu Leu Leu Gly Ala 
        35                  40                  45              


Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu His 
    50                  55                  60                  


Val Asn Gly Phe Asn Gly Asp Ser Glu Lys Ala Thr Lys Val Gln Asp 
65                  70                  75                  80  


Ile Lys Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala Ala Met 
                85                  90                  95      


Ser Asn Leu Val Pro Pro Val Glu Leu Ala Asn Pro Glu Asn Gln Phe 
            100                 105                 110         


Arg Val Asp Tyr Ile Leu Ser Val Met Asn Val Pro Asp Phe Asp Phe 
        115                 120                 125             


Pro Pro Glu Phe Tyr Glu His Ala Lys Ala Leu Trp Glu Asp Glu Gly 
    130                 135                 140                 


Val Arg Ala Cys Tyr Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp Cys 
145                 150                 155                 160 


Ala Gln Tyr Phe Leu Asp Lys Ile Asp Val Ile Lys Gln Ala Asp Tyr 
                165                 170                 175     


Val Pro Ser Asp Gln Asp Leu Leu Arg Cys Arg Val Leu Thr Ser Gly 
            180                 185                 190         


Ile Phe Glu Thr Lys Phe Gln Val Asp Lys Val Asn Phe His Met Phe 
        195                 200                 205             


Asp Val Gly Gly Gln Arg Asp Glu Arg Arg Lys Trp Ile Gln Cys Phe 
    210                 215                 220                 


Asn Asp Val Thr Ala Ile Ile Phe Val Val Ala Ser Ser Ser Tyr Asn 
225                 230                 235                 240 


Met Val Ile Arg Glu Asp Asn Gln Thr Asn Arg Leu Gln Glu Ala Leu 
                245                 250                 255     


Asn Leu Phe Lys Ser Ile Trp Asn Asn Arg Trp Leu Arg Thr Ile Ser 
            260                 265                 270         


Val Ile Leu Phe Leu Asn Lys Gln Asp Leu Leu Ala Glu Lys Val Leu 
        275                 280                 285             


Ala Gly Lys Ser Lys Ile Glu Asp Tyr Phe Pro Glu Phe Ala Arg Tyr 
    290                 295                 300                 


Thr Thr Pro Glu Asp Ala Thr Pro Glu Pro Gly Glu Asp Pro Arg Val 
305                 310                 315                 320 


Thr Arg Ala Lys Tyr Phe Ile Arg Asp Glu Phe Leu Arg Ile Ser Thr 
                325                 330                 335     


Ala Ser Gly Asp Gly Arg His Tyr Cys Tyr Pro His Phe Thr Cys Ala 
            340                 345                 350         


Val Asp Thr Glu Asn Ile Arg Arg Val Phe Asn Asp Cys Arg Asp Ile 
        355                 360                 365             


Ile Gln Arg Met His Leu Arg Gln Tyr Glu Leu Leu 
    370                 375                 380 


<210>  6061
<211>  394
<212>  PRT
<213>  Homo Sapiens

<400>  6061

Met Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp Gln Arg Asn Glu Glu 
1               5                   10                  15      


Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu Gln Lys 
            20                  25                  30          


Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu Leu Leu Leu Gly Ala 
        35                  40                  45              


Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu His 
    50                  55                  60                  


Val Asn Gly Phe Asn Gly Glu Gly Gly Glu Glu Asp Pro Gln Ala Ala 
65                  70                  75                  80  


Arg Ser Asn Ser Asp Gly Glu Lys Ala Thr Lys Val Gln Asp Ile Lys 
                85                  90                  95      


Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala Ala Met Ser Asn 
            100                 105                 110         


Leu Val Pro Pro Val Glu Leu Ala Asn Pro Glu Asn Gln Phe Arg Val 
        115                 120                 125             


Asp Tyr Ile Leu Ser Val Met Asn Val Pro Asp Phe Asp Phe Pro Pro 
    130                 135                 140                 


Glu Phe Tyr Glu His Ala Lys Ala Leu Trp Glu Asp Glu Gly Val Arg 
145                 150                 155                 160 


Ala Cys Tyr Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp Cys Ala Gln 
                165                 170                 175     


Tyr Phe Leu Asp Lys Ile Asp Val Ile Lys Gln Ala Asp Tyr Val Pro 
            180                 185                 190         


Ser Asp Gln Asp Leu Leu Arg Cys Arg Val Leu Thr Ser Gly Ile Phe 
        195                 200                 205             


Glu Thr Lys Phe Gln Val Asp Lys Val Asn Phe His Met Phe Asp Val 
    210                 215                 220                 


Gly Gly Gln Arg Asp Glu Arg Arg Lys Trp Ile Gln Cys Phe Asn Asp 
225                 230                 235                 240 


Val Thr Ala Ile Ile Phe Val Val Ala Ser Ser Ser Tyr Asn Met Val 
                245                 250                 255     


Ile Arg Glu Asp Asn Gln Thr Asn Arg Leu Gln Glu Ala Leu Asn Leu 
            260                 265                 270         


Phe Lys Ser Ile Trp Asn Asn Arg Trp Leu Arg Thr Ile Ser Val Ile 
        275                 280                 285             


Leu Phe Leu Asn Lys Gln Asp Leu Leu Ala Glu Lys Val Leu Ala Gly 
    290                 295                 300                 


Lys Ser Lys Ile Glu Asp Tyr Phe Pro Glu Phe Ala Arg Tyr Thr Thr 
305                 310                 315                 320 


Pro Glu Asp Ala Thr Pro Glu Pro Gly Glu Asp Pro Arg Val Thr Arg 
                325                 330                 335     


Ala Lys Tyr Phe Ile Arg Asp Glu Phe Leu Arg Ile Ser Thr Ala Ser 
            340                 345                 350         


Gly Asp Gly Arg His Tyr Cys Tyr Pro His Phe Thr Cys Ala Val Asp 
        355                 360                 365             


Thr Glu Asn Ile Arg Arg Val Phe Asn Asp Cys Arg Asp Ile Ile Gln 
    370                 375                 380                 


Arg Met His Leu Arg Gln Tyr Glu Leu Leu 
385                 390                 


<210>  6062
<211>  87
<212>  PRT
<213>  Homo Sapiens

<400>  6062

Met Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp Gln Arg Asn Glu Glu 
1               5                   10                  15      


Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu Gln Lys 
            20                  25                  30          


Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu Leu Leu Leu Gly Ala 
        35                  40                  45              


Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu His 
    50                  55                  60                  


Val Asn Gly Phe Asn Gly Glu Gly Gly Glu Glu Asp Pro Gln Ala Ala 
65                  70                  75                  80  


Arg Ser Asn Ser Asp Gly Ile 
                85          


<210>  6063
<211>  395
<212>  PRT
<213>  Homo Sapiens

<400>  6063

Met Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp Gln Arg Asn Glu Glu 
1               5                   10                  15      


Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu Gln Lys 
            20                  25                  30          


Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu Leu Leu Leu Gly Ala 
        35                  40                  45              


Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu His 
    50                  55                  60                  


Val Asn Gly Phe Asn Gly Glu Gly Gly Glu Glu Asp Pro Gln Ala Ala 
65                  70                  75                  80  


Arg Ser Asn Ser Asp Gly Ser Glu Lys Ala Thr Lys Val Gln Asp Ile 
                85                  90                  95      


Lys Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala Ala Met Ser 
            100                 105                 110         


Asn Leu Val Pro Pro Val Glu Leu Ala Asn Pro Glu Asn Gln Phe Arg 
        115                 120                 125             


Val Asp Tyr Ile Leu Ser Val Met Asn Val Pro Asp Phe Asp Phe Pro 
    130                 135                 140                 


Pro Glu Phe Tyr Glu His Ala Lys Ala Leu Trp Glu Asp Glu Gly Val 
145                 150                 155                 160 


Arg Ala Cys Tyr Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp Cys Ala 
                165                 170                 175     


Gln Tyr Phe Leu Asp Lys Ile Asp Val Ile Lys Gln Ala Asp Tyr Val 
            180                 185                 190         


Pro Ser Asp Gln Asp Leu Leu Arg Cys Arg Val Leu Thr Ser Gly Ile 
        195                 200                 205             


Phe Glu Thr Lys Phe Gln Val Asp Lys Val Asn Phe His Met Phe Asp 
    210                 215                 220                 


Val Gly Gly Gln Arg Asp Glu Arg Arg Lys Trp Ile Gln Cys Phe Asn 
225                 230                 235                 240 


Asp Val Thr Ala Ile Ile Phe Val Val Ala Ser Ser Ser Tyr Asn Met 
                245                 250                 255     


Val Ile Arg Glu Asp Asn Gln Thr Asn Arg Leu Gln Glu Ala Leu Asn 
            260                 265                 270         


Leu Phe Lys Ser Ile Trp Asn Asn Arg Trp Leu Arg Thr Ile Ser Val 
        275                 280                 285             


Ile Leu Phe Leu Asn Lys Gln Asp Leu Leu Ala Glu Lys Val Leu Ala 
    290                 295                 300                 


Gly Lys Ser Lys Ile Glu Asp Tyr Phe Pro Glu Phe Ala Arg Tyr Thr 
305                 310                 315                 320 


Thr Pro Glu Asp Ala Thr Pro Glu Pro Gly Glu Asp Pro Arg Val Thr 
                325                 330                 335     


Arg Ala Lys Tyr Phe Ile Arg Asp Glu Phe Leu Arg Ile Ser Thr Ala 
            340                 345                 350         


Ser Gly Asp Gly Arg His Tyr Cys Tyr Pro His Phe Thr Cys Ala Val 
        355                 360                 365             


Asp Thr Glu Asn Ile Arg Arg Val Phe Asn Asp Cys Arg Asp Ile Ile 
    370                 375                 380                 


Gln Arg Met His Leu Arg Gln Tyr Glu Leu Leu 
385                 390                 395 


<210>  6064
<211>  1023
<212>  PRT
<213>  Homo Sapiens

<400>  6064

Met Gly Val Arg Asn Cys Leu Tyr Gly Asn Asn Met Ser Gly Gln Arg 
1               5                   10                  15      


Asp Ile Pro Pro Glu Ile Gly Glu Gln Pro Glu Gln Pro Pro Leu Glu 
            20                  25                  30          


Ala Pro Gly Ala Ala Ala Pro Gly Ala Gly Pro Ser Pro Ala Glu Glu 
        35                  40                  45              


Met Glu Thr Glu Pro Pro His Asn Glu Pro Ile Pro Val Glu Asn Asp 
    50                  55                  60                  


Gly Glu Ala Cys Gly Pro Pro Glu Val Ser Arg Pro Asn Phe Gln Val 
65                  70                  75                  80  


Leu Asn Pro Ala Phe Arg Glu Ala Gly Ala His Gly Ser Tyr Ser Pro 
                85                  90                  95      


Pro Pro Glu Glu Ala Met Pro Phe Glu Ala Glu Gln Pro Ser Leu Gly 
            100                 105                 110         


Gly Phe Trp Pro Thr Leu Glu Gln Pro Gly Phe Pro Ser Gly Val His 
        115                 120                 125             


Ala Gly Leu Glu Ala Phe Gly Pro Ala Leu Met Glu Pro Gly Ala Phe 
    130                 135                 140                 


Ser Gly Ala Arg Pro Gly Leu Gly Gly Tyr Ser Pro Pro Pro Glu Glu 
145                 150                 155                 160 


Ala Met Pro Phe Glu Phe Asp Gln Pro Ala Gln Arg Gly Cys Ser Gln 
                165                 170                 175     


Leu Leu Leu Gln Val Pro Asp Leu Ala Pro Gly Gly Pro Gly Ala Ala 
            180                 185                 190         


Gly Val Pro Gly Ala Pro Pro Glu Glu Pro Gln Ala Leu Arg Pro Ala 
        195                 200                 205             


Lys Ala Gly Ser Arg Gly Gly Tyr Ser Pro Pro Pro Glu Glu Thr Met 
    210                 215                 220                 


Pro Phe Glu Leu Asp Gly Glu Gly Phe Gly Asp Asp Ser Pro Pro Pro 
225                 230                 235                 240 


Gly Leu Ser Arg Val Ile Ala Gln Val Asp Gly Ser Ser Gln Phe Ala 
                245                 250                 255     


Ala Val Ala Ala Ser Ser Ala Val Arg Leu Thr Pro Ala Ala Asn Ala 
            260                 265                 270         


Pro Pro Leu Trp Val Pro Gly Ala Ile Gly Ser Pro Ser Gln Glu Ala 
        275                 280                 285             


Val Arg Pro Pro Ser Asn Phe Thr Gly Ser Ser Pro Trp Met Glu Ile 
    290                 295                 300                 


Ser Gly Pro Pro Phe Glu Ile Gly Ser Ala Pro Ala Gly Val Asp Asp 
305                 310                 315                 320 


Thr Pro Val Asn Met Asp Ser Pro Pro Ile Ala Leu Asp Gly Pro Pro 
                325                 330                 335     


Ile Lys Val Ser Gly Ala Pro Asp Lys Arg Glu Arg Ala Glu Arg Pro 
            340                 345                 350         


Pro Val Glu Glu Glu Ala Ala Glu Met Glu Gly Ala Ala Asp Ala Ala 
        355                 360                 365             


Glu Gly Gly Lys Val Pro Ser Pro Gly Tyr Gly Ser Pro Ala Ala Gly 
    370                 375                 380                 


Ala Ala Ser Ala Asp Thr Ala Ala Arg Ala Ala Pro Ala Ala Pro Ala 
385                 390                 395                 400 


Asp Pro Asp Ser Gly Ala Thr Pro Glu Asp Pro Asp Ser Gly Thr Ala 
                405                 410                 415     


Pro Ala Asp Pro Asp Ser Gly Ala Phe Ala Ala Asp Pro Asp Ser Gly 
            420                 425                 430         


Ala Ala Pro Ala Ala Pro Ala Asp Pro Asp Ser Gly Ala Ala Pro Asp 
        435                 440                 445             


Ala Pro Ala Asp Pro Asp Ser Gly Ala Ala Pro Asp Ala Pro Ala Asp 
    450                 455                 460                 


Pro Asp Ala Gly Ala Ala Pro Glu Ala Pro Ala Ala Pro Ala Ala Ala 
465                 470                 475                 480 


Glu Thr Arg Ala Ala His Val Ala Pro Ala Ala Pro Asp Ala Gly Ala 
                485                 490                 495     


Pro Thr Ala Pro Ala Ala Ser Ala Thr Arg Ala Ala Gln Val Arg Arg 
            500                 505                 510         


Ala Ala Ser Ala Ala Pro Ala Ser Gly Ala Arg Arg Lys Ile His Leu 
        515                 520                 525             


Arg Pro Pro Ser Pro Glu Ile Gln Ala Ala Asp Pro Pro Thr Pro Arg 
    530                 535                 540                 


Pro Thr Arg Ala Ser Ala Trp Arg Gly Lys Ser Glu Ser Ser Arg Gly 
545                 550                 555                 560 


Arg Arg Val Tyr Tyr Asp Glu Gly Val Ala Ser Ser Asp Asp Asp Ser 
                565                 570                 575     


Ser Gly Asp Glu Ser Asp Asp Gly Thr Ser Gly Cys Leu Arg Trp Phe 
            580                 585                 590         


Gln His Arg Arg Asn Arg Arg Arg Arg Lys Pro Gln Arg Asn Leu Leu 
        595                 600                 605             


Arg Asn Phe Leu Val Gln Ala Phe Gly Gly Cys Phe Gly Arg Ser Glu 
    610                 615                 620                 


Ser Pro Gln Pro Lys Ala Ser Arg Ser Leu Lys Val Lys Lys Val Pro 
625                 630                 635                 640 


Leu Ala Glu Lys Arg Arg Gln Met Arg Lys Glu Ala Leu Glu Lys Arg 
                645                 650                 655     


Ala Gln Lys Arg Ala Glu Lys Lys Arg Ser Lys Leu Ile Asp Lys Gln 
            660                 665                 670         


Leu Gln Asp Glu Lys Met Gly Tyr Met Cys Thr His Arg Leu Leu Leu 
        675                 680                 685             


Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg 
    690                 695                 700                 


Ile Leu His Val Asn Gly Phe Asn Gly Asp Ser Glu Lys Ala Thr Lys 
705                 710                 715                 720 


Val Gln Asp Ile Lys Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val 
                725                 730                 735     


Ala Ala Met Ser Asn Leu Val Pro Pro Val Glu Leu Ala Asn Pro Glu 
            740                 745                 750         


Asn Gln Phe Arg Val Asp Tyr Ile Leu Ser Val Met Asn Val Pro Asp 
        755                 760                 765             


Phe Asp Phe Pro Pro Glu Phe Tyr Glu His Ala Lys Ala Leu Trp Glu 
    770                 775                 780                 


Asp Glu Gly Val Arg Ala Cys Tyr Glu Arg Ser Asn Glu Tyr Gln Leu 
785                 790                 795                 800 


Ile Asp Cys Ala Gln Tyr Phe Leu Asp Lys Ile Asp Val Ile Lys Gln 
                805                 810                 815     


Ala Asp Tyr Val Pro Ser Asp Gln Asp Leu Leu Arg Cys Arg Val Leu 
            820                 825                 830         


Thr Ser Gly Ile Phe Glu Thr Lys Phe Gln Val Asp Lys Val Asn Phe 
        835                 840                 845             


His Met Phe Asp Val Gly Gly Gln Arg Asp Glu Arg Arg Lys Trp Ile 
    850                 855                 860                 


Gln Cys Phe Asn Asp Val Thr Ala Ile Ile Phe Val Val Ala Ser Ser 
865                 870                 875                 880 


Ser Tyr Asn Met Val Ile Arg Glu Asp Asn Gln Thr Asn Arg Leu Gln 
                885                 890                 895     


Glu Ala Leu Asn Leu Phe Lys Ser Ile Trp Asn Asn Arg Trp Leu Arg 
            900                 905                 910         


Thr Ile Ser Val Ile Leu Phe Leu Asn Lys Gln Asp Leu Leu Ala Glu 
        915                 920                 925             


Lys Val Leu Ala Gly Lys Ser Lys Ile Glu Asp Tyr Phe Pro Glu Phe 
    930                 935                 940                 


Ala Arg Tyr Thr Thr Pro Glu Asp Ala Thr Pro Glu Pro Gly Glu Asp 
945                 950                 955                 960 


Pro Arg Val Thr Arg Ala Lys Tyr Phe Ile Arg Asp Glu Phe Leu Arg 
                965                 970                 975     


Ile Ser Thr Ala Ser Gly Asp Gly Arg His Tyr Cys Tyr Pro His Phe 
            980                 985                 990         


Thr Cys Ala Val Asp Thr Glu Asn  Ile Arg Arg Val Phe  Asn Asp Cys 
        995                 1000                 1005             


Arg Asp  Ile Ile Gln Arg Met  His Leu Arg Gln Tyr  Glu Leu Leu 
    1010                 1015                 1020             


<210>  6065
<211>  720
<212>  PRT
<213>  Homo Sapiens

<400>  6065

Met Gly Val Arg Asn Cys Leu Tyr Gly Asn Asn Met Ser Gly Gln Arg 
1               5                   10                  15      


Asp Ile Pro Pro Glu Ile Gly Glu Gln Pro Glu Gln Pro Pro Leu Glu 
            20                  25                  30          


Ala Pro Gly Ala Ala Ala Pro Gly Ala Gly Pro Ser Pro Ala Glu Glu 
        35                  40                  45              


Met Glu Thr Glu Pro Pro His Asn Glu Pro Ile Pro Val Glu Asn Asp 
    50                  55                  60                  


Gly Glu Ala Cys Gly Pro Pro Glu Val Ser Arg Pro Asn Phe Gln Val 
65                  70                  75                  80  


Leu Asn Pro Ala Phe Arg Glu Ala Gly Ala His Gly Ser Tyr Ser Pro 
                85                  90                  95      


Pro Pro Glu Glu Ala Met Pro Phe Glu Ala Glu Gln Pro Ser Leu Gly 
            100                 105                 110         


Gly Phe Trp Pro Thr Leu Glu Gln Pro Gly Phe Pro Ser Gly Val His 
        115                 120                 125             


Ala Gly Leu Glu Ala Phe Gly Pro Ala Leu Met Glu Pro Gly Ala Phe 
    130                 135                 140                 


Ser Gly Ala Arg Pro Gly Leu Gly Gly Tyr Ser Pro Pro Pro Glu Glu 
145                 150                 155                 160 


Ala Met Pro Phe Glu Phe Asp Gln Pro Ala Gln Arg Gly Cys Ser Gln 
                165                 170                 175     


Leu Leu Leu Gln Val Pro Asp Leu Ala Pro Gly Gly Pro Gly Ala Ala 
            180                 185                 190         


Gly Val Pro Gly Ala Pro Pro Glu Glu Pro Gln Ala Leu Arg Pro Ala 
        195                 200                 205             


Lys Ala Gly Ser Arg Gly Gly Tyr Ser Pro Pro Pro Glu Glu Thr Met 
    210                 215                 220                 


Pro Phe Glu Leu Asp Gly Glu Gly Phe Gly Asp Asp Ser Pro Pro Pro 
225                 230                 235                 240 


Gly Leu Ser Arg Val Ile Ala Gln Val Asp Gly Ser Ser Gln Phe Ala 
                245                 250                 255     


Ala Val Ala Ala Ser Ser Ala Val Arg Leu Thr Pro Ala Ala Asn Ala 
            260                 265                 270         


Pro Pro Leu Trp Val Pro Gly Ala Ile Gly Ser Pro Ser Gln Glu Ala 
        275                 280                 285             


Val Arg Pro Pro Ser Asn Phe Thr Gly Ser Ser Pro Trp Met Glu Ile 
    290                 295                 300                 


Ser Gly Pro Pro Phe Glu Ile Gly Ser Ala Pro Ala Gly Val Asp Asp 
305                 310                 315                 320 


Thr Pro Val Asn Met Asp Ser Pro Pro Ile Ala Leu Asp Gly Pro Pro 
                325                 330                 335     


Ile Lys Val Ser Gly Ala Pro Asp Lys Arg Glu Arg Ala Glu Arg Pro 
            340                 345                 350         


Pro Val Glu Glu Glu Ala Ala Glu Met Glu Gly Ala Ala Asp Ala Ala 
        355                 360                 365             


Glu Gly Gly Lys Val Pro Ser Pro Gly Tyr Gly Ser Pro Ala Ala Gly 
    370                 375                 380                 


Ala Ala Ser Ala Asp Thr Ala Ala Arg Ala Ala Pro Ala Ala Pro Ala 
385                 390                 395                 400 


Asp Pro Asp Ser Gly Ala Thr Pro Glu Asp Pro Asp Ser Gly Thr Ala 
                405                 410                 415     


Pro Ala Asp Pro Asp Ser Gly Ala Phe Ala Ala Asp Pro Asp Ser Gly 
            420                 425                 430         


Ala Ala Pro Ala Ala Pro Ala Asp Pro Asp Ser Gly Ala Ala Pro Asp 
        435                 440                 445             


Ala Pro Ala Asp Pro Asp Ser Gly Ala Ala Pro Asp Ala Pro Ala Asp 
    450                 455                 460                 


Pro Asp Ala Gly Ala Ala Pro Glu Ala Pro Ala Ala Pro Ala Ala Ala 
465                 470                 475                 480 


Glu Thr Arg Ala Ala His Val Ala Pro Ala Ala Pro Asp Ala Gly Ala 
                485                 490                 495     


Pro Thr Ala Pro Ala Ala Ser Ala Thr Arg Ala Ala Gln Val Arg Arg 
            500                 505                 510         


Ala Ala Ser Ala Ala Pro Ala Ser Gly Ala Arg Arg Lys Ile His Leu 
        515                 520                 525             


Arg Pro Pro Ser Pro Glu Ile Gln Ala Ala Asp Pro Pro Thr Pro Arg 
    530                 535                 540                 


Pro Thr Arg Ala Ser Ala Trp Arg Gly Lys Ser Glu Ser Ser Arg Gly 
545                 550                 555                 560 


Arg Arg Val Tyr Tyr Asp Glu Gly Val Ala Ser Ser Asp Asp Asp Ser 
                565                 570                 575     


Ser Gly Asp Glu Ser Asp Asp Gly Thr Ser Gly Cys Leu Arg Trp Phe 
            580                 585                 590         


Gln His Arg Arg Asn Arg Arg Arg Arg Lys Pro Gln Arg Asn Leu Leu 
        595                 600                 605             


Arg Asn Phe Leu Val Gln Ala Phe Gly Gly Cys Phe Gly Arg Ser Glu 
    610                 615                 620                 


Ser Pro Gln Pro Lys Ala Ser Arg Ser Leu Lys Val Lys Lys Val Pro 
625                 630                 635                 640 


Leu Ala Glu Lys Arg Arg Gln Met Arg Lys Glu Ala Leu Glu Lys Arg 
                645                 650                 655     


Ala Gln Lys Arg Ala Glu Lys Lys Arg Ser Lys Leu Ile Asp Lys Gln 
            660                 665                 670         


Leu Gln Asp Glu Lys Met Gly Tyr Met Cys Thr His Arg Leu Leu Leu 
        675                 680                 685             


Leu Gly Arg Lys Val Val Pro Ser Asp Thr Glu Gly Arg Phe Arg Leu 
    690                 695                 700                 


Asp Arg Pro Ala Pro Ala Thr Val Ser Trp Thr Gly Arg Gly Phe Arg 
705                 710                 715                 720 


<210>  6066
<211>  1037
<212>  PRT
<213>  Homo Sapiens

<400>  6066

Met Gly Val Arg Asn Cys Leu Tyr Gly Asn Asn Met Ser Gly Gln Arg 
1               5                   10                  15      


Asp Ile Pro Pro Glu Ile Gly Glu Gln Pro Glu Gln Pro Pro Leu Glu 
            20                  25                  30          


Ala Pro Gly Ala Ala Ala Pro Gly Ala Gly Pro Ser Pro Ala Glu Glu 
        35                  40                  45              


Met Glu Thr Glu Pro Pro His Asn Glu Pro Ile Pro Val Glu Asn Asp 
    50                  55                  60                  


Gly Glu Ala Cys Gly Pro Pro Glu Val Ser Arg Pro Asn Phe Gln Val 
65                  70                  75                  80  


Leu Asn Pro Ala Phe Arg Glu Ala Gly Ala His Gly Ser Tyr Ser Pro 
                85                  90                  95      


Pro Pro Glu Glu Ala Met Pro Phe Glu Ala Glu Gln Pro Ser Leu Gly 
            100                 105                 110         


Gly Phe Trp Pro Thr Leu Glu Gln Pro Gly Phe Pro Ser Gly Val His 
        115                 120                 125             


Ala Gly Leu Glu Ala Phe Gly Pro Ala Leu Met Glu Pro Gly Ala Phe 
    130                 135                 140                 


Ser Gly Ala Arg Pro Gly Leu Gly Gly Tyr Ser Pro Pro Pro Glu Glu 
145                 150                 155                 160 


Ala Met Pro Phe Glu Phe Asp Gln Pro Ala Gln Arg Gly Cys Ser Gln 
                165                 170                 175     


Leu Leu Leu Gln Val Pro Asp Leu Ala Pro Gly Gly Pro Gly Ala Ala 
            180                 185                 190         


Gly Val Pro Gly Ala Pro Pro Glu Glu Pro Gln Ala Leu Arg Pro Ala 
        195                 200                 205             


Lys Ala Gly Ser Arg Gly Gly Tyr Ser Pro Pro Pro Glu Glu Thr Met 
    210                 215                 220                 


Pro Phe Glu Leu Asp Gly Glu Gly Phe Gly Asp Asp Ser Pro Pro Pro 
225                 230                 235                 240 


Gly Leu Ser Arg Val Ile Ala Gln Val Asp Gly Ser Ser Gln Phe Ala 
                245                 250                 255     


Ala Val Ala Ala Ser Ser Ala Val Arg Leu Thr Pro Ala Ala Asn Ala 
            260                 265                 270         


Pro Pro Leu Trp Val Pro Gly Ala Ile Gly Ser Pro Ser Gln Glu Ala 
        275                 280                 285             


Val Arg Pro Pro Ser Asn Phe Thr Gly Ser Ser Pro Trp Met Glu Ile 
    290                 295                 300                 


Ser Gly Pro Pro Phe Glu Ile Gly Ser Ala Pro Ala Gly Val Asp Asp 
305                 310                 315                 320 


Thr Pro Val Asn Met Asp Ser Pro Pro Ile Ala Leu Asp Gly Pro Pro 
                325                 330                 335     


Ile Lys Val Ser Gly Ala Pro Asp Lys Arg Glu Arg Ala Glu Arg Pro 
            340                 345                 350         


Pro Val Glu Glu Glu Ala Ala Glu Met Glu Gly Ala Ala Asp Ala Ala 
        355                 360                 365             


Glu Gly Gly Lys Val Pro Ser Pro Gly Tyr Gly Ser Pro Ala Ala Gly 
    370                 375                 380                 


Ala Ala Ser Ala Asp Thr Ala Ala Arg Ala Ala Pro Ala Ala Pro Ala 
385                 390                 395                 400 


Asp Pro Asp Ser Gly Ala Thr Pro Glu Asp Pro Asp Ser Gly Thr Ala 
                405                 410                 415     


Pro Ala Asp Pro Asp Ser Gly Ala Phe Ala Ala Asp Pro Asp Ser Gly 
            420                 425                 430         


Ala Ala Pro Ala Ala Pro Ala Asp Pro Asp Ser Gly Ala Ala Pro Asp 
        435                 440                 445             


Ala Pro Ala Asp Pro Asp Ser Gly Ala Ala Pro Asp Ala Pro Ala Asp 
    450                 455                 460                 


Pro Asp Ala Gly Ala Ala Pro Glu Ala Pro Ala Ala Pro Ala Ala Ala 
465                 470                 475                 480 


Glu Thr Arg Ala Ala His Val Ala Pro Ala Ala Pro Asp Ala Gly Ala 
                485                 490                 495     


Pro Thr Ala Pro Ala Ala Ser Ala Thr Arg Ala Ala Gln Val Arg Arg 
            500                 505                 510         


Ala Ala Ser Ala Ala Pro Ala Ser Gly Ala Arg Arg Lys Ile His Leu 
        515                 520                 525             


Arg Pro Pro Ser Pro Glu Ile Gln Ala Ala Asp Pro Pro Thr Pro Arg 
    530                 535                 540                 


Pro Thr Arg Ala Ser Ala Trp Arg Gly Lys Ser Glu Ser Ser Arg Gly 
545                 550                 555                 560 


Arg Arg Val Tyr Tyr Asp Glu Gly Val Ala Ser Ser Asp Asp Asp Ser 
                565                 570                 575     


Ser Gly Asp Glu Ser Asp Asp Gly Thr Ser Gly Cys Leu Arg Trp Phe 
            580                 585                 590         


Gln His Arg Arg Asn Arg Arg Arg Arg Lys Pro Gln Arg Asn Leu Leu 
        595                 600                 605             


Arg Asn Phe Leu Val Gln Ala Phe Gly Gly Cys Phe Gly Arg Ser Glu 
    610                 615                 620                 


Ser Pro Gln Pro Lys Ala Ser Arg Ser Leu Lys Val Lys Lys Val Pro 
625                 630                 635                 640 


Leu Ala Glu Lys Arg Arg Gln Met Arg Lys Glu Ala Leu Glu Lys Arg 
                645                 650                 655     


Ala Gln Lys Arg Ala Glu Lys Lys Arg Ser Lys Leu Ile Asp Lys Gln 
            660                 665                 670         


Leu Gln Asp Glu Lys Met Gly Tyr Met Cys Thr His Arg Leu Leu Leu 
        675                 680                 685             


Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg 
    690                 695                 700                 


Ile Leu His Val Asn Gly Phe Asn Gly Glu Gly Gly Glu Glu Asp Pro 
705                 710                 715                 720 


Gln Ala Ala Arg Ser Asn Ser Asp Gly Glu Lys Ala Thr Lys Val Gln 
                725                 730                 735     


Asp Ile Lys Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala Ala 
            740                 745                 750         


Met Ser Asn Leu Val Pro Pro Val Glu Leu Ala Asn Pro Glu Asn Gln 
        755                 760                 765             


Phe Arg Val Asp Tyr Ile Leu Ser Val Met Asn Val Pro Asp Phe Asp 
    770                 775                 780                 


Phe Pro Pro Glu Phe Tyr Glu His Ala Lys Ala Leu Trp Glu Asp Glu 
785                 790                 795                 800 


Gly Val Arg Ala Cys Tyr Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp 
                805                 810                 815     


Cys Ala Gln Tyr Phe Leu Asp Lys Ile Asp Val Ile Lys Gln Ala Asp 
            820                 825                 830         


Tyr Val Pro Ser Asp Gln Asp Leu Leu Arg Cys Arg Val Leu Thr Ser 
        835                 840                 845             


Gly Ile Phe Glu Thr Lys Phe Gln Val Asp Lys Val Asn Phe His Met 
    850                 855                 860                 


Phe Asp Val Gly Gly Gln Arg Asp Glu Arg Arg Lys Trp Ile Gln Cys 
865                 870                 875                 880 


Phe Asn Asp Val Thr Ala Ile Ile Phe Val Val Ala Ser Ser Ser Tyr 
                885                 890                 895     


Asn Met Val Ile Arg Glu Asp Asn Gln Thr Asn Arg Leu Gln Glu Ala 
            900                 905                 910         


Leu Asn Leu Phe Lys Ser Ile Trp Asn Asn Arg Trp Leu Arg Thr Ile 
        915                 920                 925             


Ser Val Ile Leu Phe Leu Asn Lys Gln Asp Leu Leu Ala Glu Lys Val 
    930                 935                 940                 


Leu Ala Gly Lys Ser Lys Ile Glu Asp Tyr Phe Pro Glu Phe Ala Arg 
945                 950                 955                 960 


Tyr Thr Thr Pro Glu Asp Ala Thr Pro Glu Pro Gly Glu Asp Pro Arg 
                965                 970                 975     


Val Thr Arg Ala Lys Tyr Phe Ile Arg Asp Glu Phe Leu Arg Ile Ser 
            980                 985                 990         


Thr Ala Ser Gly Asp Gly Arg His  Tyr Cys Tyr Pro His  Phe Thr Cys 
        995                 1000                 1005             


Ala Val  Asp Thr Glu Asn Ile  Arg Arg Val Phe Asn  Asp Cys Arg 
    1010                 1015                 1020             


Asp Ile  Ile Gln Arg Met His  Leu Arg Gln Tyr Glu  Leu Leu 
    1025                 1030                 1035         


<210>  6067
<211>  120
<212>  PRT
<213>  Homo Sapiens

<400>  6067

Met Arg Ile Leu His Val Asn Gly Phe Asn Gly Glu Gly Gly Glu Glu 
1               5                   10                  15      


Asp Pro Gln Ala Ala Arg Ser Asn Ser Asp Gly Glu Lys Ala Thr Lys 
            20                  25                  30          


Val Gln Asp Ile Lys Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val 
        35                  40                  45              


Ala Ala Met Ser Asn Leu Val Pro Pro Val Glu Leu Ala Asn Pro Glu 
    50                  55                  60                  


Asn Gln Phe Arg Val Asp Tyr Ile Leu Ser Val Met Asn Val Pro Asp 
65                  70                  75                  80  


Phe Asp Phe Pro Pro Glu Phe Tyr Glu His Ala Lys Ala Leu Trp Glu 
                85                  90                  95      


Asp Glu Gly Val Arg Ala Cys Tyr Glu Arg Ser Asn Glu Tyr Gln Leu 
            100                 105                 110         


Ile Asp Cys Ala Gln Tyr Phe Leu 
        115                 120 


<210>  6068
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  6068

Met Arg Ile Leu His Val Asn Gly Phe Asn Gly Glu Gly Gly Glu Glu 
1               5                   10                  15      


Asp Pro Gln Ala Ala Arg Ser Asn Ser Asp Gly Glu Lys Ala Thr Lys 
            20                  25                  30          


Val Gln Asp Ile Lys Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val 
        35                  40                  45              


Ala Ala Met Ser Asn Leu Val Pro Pro Val Glu Leu Ala Asn Pro Glu 
    50                  55                  60                  


Asn Gln Phe Arg Val Asp Tyr Ile Leu Ser Val Met Asn Val Pro Asp 
65                  70                  75                  80  


Phe Asp Phe Pro Pro Glu Phe Tyr Glu His Ala Lys Ala Leu Trp Glu 
                85                  90                  95      


Asp Glu Gly Val Arg Ala Cys Tyr Glu Arg Ser Asn Glu Tyr Gln Leu 
            100                 105                 110         


Ile Asp Cys Ala Gln Tyr Phe Leu Asp Lys Ile Asp Val Ile Lys Gln 
        115                 120                 125             


Ala Asp Tyr Val Pro Ser Asp Gln Asp Leu Leu Arg Cys Arg Val Leu 
    130                 135                 140                 


Thr Ser Gly Ile Phe Glu Thr Lys Phe Gln Val Asp Lys Val Asn Phe 
145                 150                 155                 160 


<210>  6069
<211>  166
<212>  PRT
<213>  Homo Sapiens

<400>  6069

Pro Glu Ser Glu Ser Asp His Glu His Glu Glu Ala Asp Leu Glu Leu 
1               5                   10                  15      


Ser Leu Pro Glu Cys Leu Glu Tyr Glu Glu Glu Phe Asp Tyr Glu Thr 
            20                  25                  30          


Glu Ser Glu Thr Glu Ser Glu Ile Glu Ser Glu Thr Asp Phe Glu Thr 
        35                  40                  45              


Glu Pro Glu Thr Ala Pro Thr Thr Glu Pro Glu Thr Glu Pro Glu Asp 
    50                  55                  60                  


Asp Arg Gly Pro Val Val Pro Lys His Ser Thr Phe Gly Gln Ser Leu 
65                  70                  75                  80  


Thr Gln Arg Leu His Ala Leu Lys Leu Arg Ser Pro Asp Ala Ser Pro 
                85                  90                  95      


Ser Arg Ala Pro Pro Ser Thr Gln Glu Pro Gln Ser Pro Arg Glu Gly 
            100                 105                 110         


Glu Glu Leu Lys Pro Glu Asp Lys Asp Pro Arg Asp Pro Glu Glu Ser 
        115                 120                 125             


Lys Glu Pro Lys Glu Glu Lys Gln Arg Arg Arg Cys Lys Pro Lys Lys 
    130                 135                 140                 


Pro Thr Arg Arg Asp Ala Ser Pro Glu Ser Pro Ser Lys Lys Gly Pro 
145                 150                 155                 160 


Ile Pro Ile Arg Arg His 
                165     


<210>  6070
<211>  193
<212>  PRT
<213>  Homo Sapiens

<400>  6070

Pro Lys Ala Ser Arg Ser Leu Lys Val Lys Lys Val Pro Leu Ala Glu 
1               5                   10                  15      


Lys Arg Arg Gln Met Arg Lys Glu Ala Leu Glu Lys Arg Ala Gln Lys 
            20                  25                  30          


Arg Ala Glu Lys Lys Arg Ser Lys Leu Ile Asp Lys Gln Leu Gln Asp 
        35                  40                  45              


Glu Lys Met Gly Tyr Met Cys Thr His Arg Leu Leu Leu Leu Gly Ala 
    50                  55                  60                  


Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu His 
65                  70                  75                  80  


Val Asn Gly Phe Asn Gly Glu Gly Gly Glu Glu Asp Pro Gln Ala Ala 
                85                  90                  95      


Arg Ser Asn Ser Asp Gly Ser Glu Lys Ala Thr Lys Val Gln Asp Ile 
            100                 105                 110         


Lys Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala Ala Met Ser 
        115                 120                 125             


Asn Leu Val Pro Pro Val Glu Leu Ala Asn Pro Glu Asn Gln Phe Arg 
    130                 135                 140                 


Val Asp Tyr Ile Leu Ser Val Met Asn Val Pro Asp Phe Asp Phe Pro 
145                 150                 155                 160 


Pro Glu Phe Tyr Glu His Ala Lys Ala Leu Trp Glu Asp Glu Gly Val 
                165                 170                 175     


Arg Ala Cys Tyr Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp Cys Ala 
            180                 185                 190         


Gln 
    


<210>  6071
<211>  61
<212>  PRT
<213>  Homo Sapiens

<400>  6071

Gln Arg Asn Glu Glu Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu 
1               5                   10                  15      


Lys Gln Leu Gln Lys Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu 
            20                  25                  30          


Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln 
        35                  40                  45              


Met Arg Ile Leu His Val Asn Gly Phe Asn Gly Glu Ile 
    50                  55                  60      


<210>  6072
<211>  199
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6072

Xaa Ala Phe Gly Gly Cys Phe Gly Arg Ser Glu Ser Pro Gln Pro Lys 
1               5                   10                  15      


Ala Ser Arg Ser Leu Lys Val Lys Lys Val Pro Leu Ala Glu Lys Arg 
            20                  25                  30          


Arg Gln Met Arg Lys Glu Ala Leu Glu Lys Arg Ala Gln Lys Arg Ala 
        35                  40                  45              


Glu Lys Lys Arg Ser Lys Leu Ile Asp Lys Gln Leu Gln Asp Glu Lys 
    50                  55                  60                  


Met Gly Tyr Met Cys Thr His Arg Leu Leu Leu Leu Gly Ala Gly Glu 
65                  70                  75                  80  


Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu His Val Asn 
                85                  90                  95      


Gly Phe Asn Gly Asp Glu Lys Ala Thr Lys Val Gln Asp Ile Lys Asn 
            100                 105                 110         


Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala Ala Met Ser Asn Leu 
        115                 120                 125             


Val Pro Pro Val Glu Leu Ala Asn Pro Glu Asn Gln Phe Arg Val Asp 
    130                 135                 140                 


Tyr Ile Leu Ser Val Met Asn Val Pro Asp Phe Asp Phe Pro Pro Glu 
145                 150                 155                 160 


Phe Tyr Glu His Ala Lys Ala Leu Trp Glu Asp Glu Gly Val Arg Ala 
                165                 170                 175     


Cys Tyr Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp Cys Ala Gln Tyr 
            180                 185                 190         


Phe Leu Asp Lys Ile Asp Val 
        195                 


<210>  6073
<211>  184
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6073

Xaa Gly Arg Arg Val Tyr Tyr Asp Glu Gly Val Ala Ser Ser Asp Asp 
1               5                   10                  15      


Asp Ser Ser Gly Asp Glu Ser Asp Asp Gly Thr Ser Gly Cys Leu Arg 
            20                  25                  30          


Trp Phe Gln His Arg Arg Asn Arg Arg Arg Arg Lys Pro Gln Arg Asn 
        35                  40                  45              


Leu Leu Arg Asn Phe Leu Val Gln Ala Phe Gly Gly Cys Phe Gly Arg 
    50                  55                  60                  


Ser Glu Ser Pro Gln Pro Lys Ala Ser Arg Ser Leu Lys Val Lys Lys 
65                  70                  75                  80  


Val Pro Leu Ala Glu Lys Arg Arg Gln Met Arg Lys Glu Ala Leu Glu 
                85                  90                  95      


Lys Arg Ala Gln Lys Arg Ala Glu Lys Lys Arg Ser Lys Leu Ile Asp 
            100                 105                 110         


Lys Gln Leu Gln Asp Glu Lys Met Gly Tyr Met Cys Thr His Arg Leu 
        115                 120                 125             


Leu Leu Leu Gly Arg Lys Val Val Pro Ser Asp Thr Glu Gly Arg Phe 
    130                 135                 140                 


Arg Leu Asp Arg Pro Ala Pro Ala Thr Val Ser Trp Thr Gly Arg Gly 
145                 150                 155                 160 


Phe Ser Val Ser Ser Leu Leu Ile Arg Ser Pro Asn Pro Pro Ala Phe 
                165                 170                 175     


Thr Val Glu Lys Pro Asp Thr Gln 
            180                 


<210>  6074
<211>  113
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6074

Xaa Thr Thr Glu Pro Glu Thr Glu Pro Glu Asp Asp Arg Gly Pro Val 
1               5                   10                  15      


Val Pro Lys His Ser Thr Phe Gly Gln Ser Leu Thr Gln Arg Leu His 
            20                  25                  30          


Ala Leu Lys Leu Arg Ser Pro Asp Ala Ser Pro Ser Arg Ala Pro Pro 
        35                  40                  45              


Ser Thr Gln Glu Pro Gln Ser Pro Arg Glu Gly Glu Glu Leu Lys Pro 
    50                  55                  60                  


Glu Asp Lys Asp Pro Arg Asp Pro Glu Glu Ser Lys Glu Pro Lys Glu 
65                  70                  75                  80  


Glu Lys Gln Arg Arg Arg Cys Lys Pro Lys Lys Pro Thr Arg Arg Asp 
                85                  90                  95      


Ala Ser Pro Glu Ser Pro Ser Lys Lys Gly Pro Ile Pro Ile Arg Arg 
            100                 105                 110         


His 
    


<210>  6075
<211>  93
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6075

Xaa Val Pro Leu Ala Glu Lys Arg Arg Gln Met Arg Lys Glu Ala Leu 
1               5                   10                  15      


Glu Lys Arg Ala Gln Lys Arg Ala Glu Lys Lys Arg Ser Lys Leu Ile 
            20                  25                  30          


Asp Lys Gln Leu Gln Asp Glu Lys Met Gly Tyr Met Cys Thr His Arg 
        35                  40                  45              


Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr Ile Val Lys 
    50                  55                  60                  


Gln Met Arg Ile Leu His Val Asn Gly Phe Asn Gly Glu Gly Gly Glu 
65                  70                  75                  80  


Glu Asp Pro Gln Ala Ala Arg Ser Asn Ser Asp Gly Ile 
                85                  90              


<210>  6076
<211>  172
<212>  PRT
<213>  Homo Sapiens

<400>  6076

Met Ala Thr Trp Ala Leu Leu Leu Leu Ala Ala Met Leu Leu Gly Asn 
1               5                   10                  15      


Pro Gly Leu Glu Val Ser Val Ser Pro Lys Gly Lys Asn Thr Ser Gly 
            20                  25                  30          


Arg Glu Ser Gly Phe Gly Trp Ala Ile Trp Met Glu Gly Leu Val Phe 
        35                  40                  45              


Ser Arg Leu Ser Pro Glu Tyr Tyr Asp Leu Ala Arg Ala His Leu Arg 
    50                  55                  60                  


Asp Glu Glu Lys Ser Cys Pro Cys Leu Ala Gln Glu Gly Pro Gln Gly 
65                  70                  75                  80  


Asp Leu Leu Thr Lys Thr Gln Glu Leu Gly Arg Asp Tyr Arg Thr Cys 
                85                  90                  95      


Leu Thr Ile Val Gln Lys Leu Lys Lys Met Val Asp Lys Pro Thr Gln 
            100                 105                 110         


Arg Ser Val Ser Asn Ala Ala Thr Arg Val Cys Arg Thr Gly Arg Ser 
        115                 120                 125             


Arg Trp Arg Asp Val Cys Arg Asn Phe Met Arg Arg Tyr Gln Ser Arg 
    130                 135                 140                 


Val Thr Gln Gly Leu Val Ala Gly Glu Thr Ala Gln Gln Ile Cys Glu 
145                 150                 155                 160 


Asp Leu Arg Leu Cys Ile Pro Ser Thr Gly Pro Leu 
                165                 170         


<210>  6077
<211>  145
<212>  PRT
<213>  Homo Sapiens

<400>  6077

Met Ala Thr Trp Ala Leu Leu Leu Leu Ala Ala Met Leu Leu Gly Asn 
1               5                   10                  15      


Pro Gly Leu Val Phe Ser Arg Leu Ser Pro Glu Tyr Tyr Asp Leu Ala 
            20                  25                  30          


Arg Ala His Leu Arg Asp Glu Glu Lys Ser Cys Pro Cys Leu Ala Gln 
        35                  40                  45              


Glu Gly Pro Gln Gly Asp Leu Leu Thr Lys Thr Gln Glu Leu Gly Arg 
    50                  55                  60                  


Asp Tyr Arg Thr Cys Leu Thr Ile Val Gln Lys Leu Lys Lys Met Val 
65                  70                  75                  80  


Asp Lys Pro Thr Gln Arg Ser Val Ser Asn Ala Ala Thr Arg Val Cys 
                85                  90                  95      


Arg Thr Gly Arg Ser Arg Trp Arg Asp Val Cys Arg Asn Phe Met Arg 
            100                 105                 110         


Arg Tyr Gln Ser Arg Val Thr Gln Gly Leu Val Ala Gly Glu Thr Ala 
        115                 120                 125             


Gln Gln Ile Cys Glu Asp Leu Arg Leu Cys Ile Pro Ser Thr Gly Pro 
    130                 135                 140                 


Leu 
145 


<210>  6078
<211>  130
<212>  PRT
<213>  Homo Sapiens

<400>  6078

Met Glu Gly Leu Val Phe Ser Arg Leu Ser Pro Glu Tyr Tyr Asp Leu 
1               5                   10                  15      


Ala Arg Ala His Leu Arg Asp Glu Glu Lys Ser Cys Pro Cys Leu Ala 
            20                  25                  30          


Gln Glu Gly Pro Gln Gly Asp Leu Leu Thr Lys Thr Gln Glu Leu Gly 
        35                  40                  45              


Arg Asp Tyr Arg Thr Cys Leu Thr Ile Val Gln Lys Leu Lys Lys Met 
    50                  55                  60                  


Val Asp Lys Pro Thr Gln Arg Ser Val Ser Asn Ala Ala Thr Arg Val 
65                  70                  75                  80  


Cys Arg Thr Gly Arg Ser Arg Trp Arg Asp Val Cys Arg Asn Phe Met 
                85                  90                  95      


Arg Arg Tyr Gln Ser Arg Val Thr Gln Gly Leu Val Ala Gly Glu Thr 
            100                 105                 110         


Ala Gln Gln Ile Cys Glu Asp Leu Arg Leu Cys Ile Pro Ser Thr Gly 
        115                 120                 125             


Pro Leu 
    130 


<210>  6079
<211>  187
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6079

Xaa His Leu Arg Asp Glu Glu Lys Ser Cys Pro Cys Leu Ala Gln Glu 
1               5                   10                  15      


Gly Pro Gln Gly Asp Leu Leu Thr Lys Thr Gln Glu Leu Gly Arg Asp 
            20                  25                  30          


Tyr Arg Thr Cys Leu Thr Ile Val Gln Lys Leu Lys Lys Met Val Asp 
        35                  40                  45              


Lys Pro Thr Gln Arg Ser Val Ser Asn Ala Ala Thr Arg Val Cys Arg 
    50                  55                  60                  


Thr Gly Arg Ser Arg Trp Arg Asp Val Cys Arg Asn Phe Met Arg Arg 
65                  70                  75                  80  


Tyr Gln Ser Arg Val Thr Gln Gly Leu Val Ala Gly Glu Thr Ala Gln 
                85                  90                  95      


Gln Ile Cys Glu Asp Leu Arg Leu Cys Ile Pro Ser Thr Gly Pro Thr 
            100                 105                 110         


Thr Cys Ser Gly Cys Arg Leu Ala Ser Arg Met Cys Leu Trp Val Pro 
        115                 120                 125             


Ser Glu Pro Ser His Leu Val Leu Trp Lys Lys His Arg Leu Leu Ser 
    130                 135                 140                 


Ser Asp Pro Gly Asn Leu Ser Asn Leu Cys Arg Leu Leu Ala Ser Ser 
145                 150                 155                 160 


Ile Gln Asn Pro Leu Ser Ser Leu Pro Pro Leu Thr Pro Ser Ala Val 
                165                 170                 175     


Leu Pro Ser His Glu Asn Lys Val Ser Ser Lys 
            180                 185         


<210>  6080
<211>  76
<212>  PRT
<213>  Homo Sapiens

<400>  6080

Met Ala Ala Gly Leu Ala Arg Leu Leu Leu Leu Leu Gly Leu Ser Ala 
1               5                   10                  15      


Gly Gly Pro Ala Pro Ala Gly Ala Ala Lys Met Lys Val Val Glu Glu 
            20                  25                  30          


Pro Asn Ala Phe Gly Val Asn Asn Pro Phe Leu Pro Gln Ala Ser Arg 
        35                  40                  45              


Leu Gln Ala Lys Arg Asp Pro Ser Pro Val Ser Glu Thr Gly Phe His 
    50                  55                  60                  


Arg Val Ser Gln Asp Gly Leu Asp Leu Leu Thr Ser 
65                  70                  75      


<210>  6081
<211>  76
<212>  PRT
<213>  Homo Sapiens

<400>  6081

Met Ala Ala Gly Leu Ala Arg Leu Leu Leu Leu Leu Gly Leu Ser Ala 
1               5                   10                  15      


Gly Gly Pro Ala Pro Ala Gly Ala Ala Lys Met Lys Val Val Glu Glu 
            20                  25                  30          


Pro Asn Ala Phe Gly Val Asn Asn Pro Phe Leu Pro Gln Ala Ser Arg 
        35                  40                  45              


Leu Gln Ala Lys Arg Asp Pro Ser Pro Val Ser Glu Thr Gly Phe His 
    50                  55                  60                  


Arg Val Ser Gln Asp Gly Leu Asp Leu Leu Thr Ser 
65                  70                  75      


<210>  6082
<211>  61
<212>  PRT
<213>  Homo Sapiens

<400>  6082

Met Ala Ala Gly Leu Ala Arg Leu Leu Leu Leu Leu Gly Leu Ser Ala 
1               5                   10                  15      


Gly Gly Pro Ala Pro Ala Gly Ala Ala Lys Met Lys Val Val Glu Glu 
            20                  25                  30          


Pro Asn Ala Phe Gly Val Asn Asn Pro Phe Leu Pro Gln Ala Ser Arg 
        35                  40                  45              


Leu Gln Ala Lys Arg Asp Pro Ser Pro Val Ser Gly Glu 
    50                  55                  60      


<210>  6083
<211>  305
<212>  PRT
<213>  Homo Sapiens

<400>  6083

Met Ala Ala Gly Leu Ala Arg Leu Leu Leu Leu Leu Gly Leu Ser Ala 
1               5                   10                  15      


Gly Gly Pro Ala Pro Ala Gly Ala Ala Lys Met Lys Val Val Glu Glu 
            20                  25                  30          


Pro Asn Ala Phe Gly Val Asn Asn Pro Phe Leu Pro Gln Ala Ser Arg 
        35                  40                  45              


Leu Gln Ala Lys Arg Asp Pro Ser Pro Val Ser Gly Pro Val His Leu 
    50                  55                  60                  


Phe Arg Leu Ser Gly Lys Cys Phe Ser Leu Val Glu Ser Thr Tyr Lys 
65                  70                  75                  80  


Tyr Glu Phe Cys Pro Phe His Asn Val Thr Gln His Glu Gln Thr Phe 
                85                  90                  95      


Arg Trp Asn Ala Tyr Ser Gly Ile Leu Gly Ile Trp His Glu Trp Glu 
            100                 105                 110         


Ile Ala Asn Asn Thr Phe Thr Gly Met Trp Met Arg Asp Gly Asp Ala 
        115                 120                 125             


Cys Arg Ser Arg Ser Arg Gln Ser Lys Val Glu Leu Ala Cys Gly Lys 
    130                 135                 140                 


Ser Asn Arg Leu Ala His Val Ser Glu Pro Ser Thr Cys Val Tyr Ala 
145                 150                 155                 160 


Leu Thr Phe Glu Thr Pro Leu Val Cys His Pro His Ala Leu Leu Val 
                165                 170                 175     


Tyr Pro Thr Leu Pro Glu Ala Leu Gln Arg Gln Trp Asp Gln Val Glu 
            180                 185                 190         


Gln Asp Leu Ala Asp Glu Leu Ile Thr Pro Gln Gly His Glu Lys Leu 
        195                 200                 205             


Leu Arg Thr Leu Phe Glu Asp Ala Gly Tyr Leu Lys Thr Pro Glu Glu 
    210                 215                 220                 


Asn Glu Pro Thr Gln Leu Glu Gly Gly Pro Asp Ser Leu Gly Phe Glu 
225                 230                 235                 240 


Thr Leu Glu Asn Cys Arg Lys Ala His Lys Glu Leu Ser Lys Glu Ile 
                245                 250                 255     


Lys Arg Leu Lys Gly Leu Leu Thr Gln His Gly Ile Pro Tyr Thr Arg 
            260                 265                 270         


Pro Thr Glu Thr Ser Asn Leu Glu His Leu Gly His Glu Thr Pro Arg 
        275                 280                 285             


Ala Lys Ser Pro Glu Gln Leu Arg Gly Asp Pro Gly Leu Arg Gly Ser 
    290                 295                 300                 


Leu 
305 


<210>  6084
<211>  185
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6084

Xaa Arg Leu Leu Leu Leu Leu Gly Leu Ser Ala Gly Gly Glu Trp Pro 
1               5                   10                  15      


Gly Arg Pro Arg Pro Gln Ala Pro Arg Ala Leu Cys Thr Pro Ala Ser 
            20                  25                  30          


Pro Leu Thr Val Ser Leu Pro Val Gly Pro Ala Pro Ala Gly Ala Ala 
        35                  40                  45              


Lys Met Lys Val Val Glu Glu Pro Asn Ala Phe Gly Val Asn Asn Pro 
    50                  55                  60                  


Phe Leu Pro Gln Ala Ser Arg Leu Gln Ala Lys Arg Asp Pro Ser Pro 
65                  70                  75                  80  


Val Ser Gly Pro Val His Leu Phe Arg Leu Ser Gly Lys Cys Phe Ser 
                85                  90                  95      


Leu Val Glu Ser Thr Tyr Lys Tyr Glu Phe Cys Pro Phe His Asn Val 
            100                 105                 110         


Thr Gln His Glu Gln Thr Phe Arg Trp Asn Ala Tyr Ser Gly Ile Leu 
        115                 120                 125             


Gly Ile Trp His Glu Trp Glu Ile Ala Asn Asn Thr Phe Thr Gly Met 
    130                 135                 140                 


Trp Met Arg Asp Gly Asp Ala Cys Arg Ser Arg Ser Arg Gln Ser Lys 
145                 150                 155                 160 


Val Glu Leu Ala Cys Gly Lys Ser Asn Arg Leu Ala His Val Ser Glu 
                165                 170                 175     


Pro Ser Thr Cys Val Tyr Ala Leu Thr 
            180                 185 


<210>  6085
<211>  92
<212>  PRT
<213>  Homo Sapiens

<400>  6085

Met Lys Pro Ile Gln Lys Leu Leu Ala Gly Leu Ile Leu Leu Thr Trp 
1               5                   10                  15      


Cys Val Glu Gly Cys Ser Ser Gln His Trp Ser Tyr Gly Leu Arg Pro 
            20                  25                  30          


Gly Gly Lys Arg Asp Ala Glu Asn Leu Ile Asp Ser Phe Gln Glu Ile 
        35                  40                  45              


Val Lys Glu Val Gly Gln Leu Ala Glu Thr Gln Arg Phe Glu Cys Thr 
    50                  55                  60                  


Thr His Gln Pro Arg Ser Pro Leu Arg Asp Leu Lys Gly Ala Leu Glu 
65                  70                  75                  80  


Ser Leu Ile Glu Glu Glu Thr Gly Gln Lys Lys Ile 
                85                  90          


<210>  6086
<211>  92
<212>  PRT
<213>  Homo Sapiens

<400>  6086

Met Lys Pro Ile Gln Lys Leu Leu Ala Gly Leu Ile Leu Leu Thr Trp 
1               5                   10                  15      


Cys Val Glu Gly Cys Ser Ser Gln His Trp Ser Tyr Gly Leu Arg Pro 
            20                  25                  30          


Gly Gly Lys Arg Asp Ala Glu Asn Leu Ile Asp Ser Phe Gln Glu Ile 
        35                  40                  45              


Val Lys Glu Val Gly Gln Leu Ala Glu Thr Gln Arg Phe Glu Cys Thr 
    50                  55                  60                  


Thr His Gln Pro Arg Ser Pro Leu Arg Asp Leu Lys Gly Ala Leu Glu 
65                  70                  75                  80  


Ser Leu Ile Glu Glu Glu Thr Gly Gln Lys Lys Ile 
                85                  90          


<210>  6087
<211>  113
<212>  PRT
<213>  Homo Sapiens

<400>  6087

Met Ala Ser Ser Arg Arg Gly Leu Leu Leu Leu Leu Leu Leu Thr Ala 
1               5                   10                  15      


His Leu Gly Pro Ser Glu Ala Gln His Trp Ser His Gly Trp Tyr Pro 
            20                  25                  30          


Gly Gly Lys Arg Ala Leu Ser Ser Ala Gln Asp Pro Gln Asn Ala Leu 
        35                  40                  45              


Arg Pro Pro Ala Gly Ser Pro Val Gln Thr Ala His Gly Leu Pro Ser 
    50                  55                  60                  


Asp Ala Leu Ala Pro Leu Asp Asp Ser Met Pro Trp Glu Gly Arg Thr 
65                  70                  75                  80  


Thr Ala Gln Trp Ser Leu His Arg Lys Arg His Leu Ala Arg Thr Leu 
                85                  90                  95      


Leu Thr Ala Ala Arg Glu Pro Arg Pro Ala Pro Pro Ser Ser Asn Lys 
            100                 105                 110         


Val 
    


<210>  6088
<211>  113
<212>  PRT
<213>  Homo Sapiens

<400>  6088

Met Ala Ser Ser Arg Arg Gly Leu Leu Leu Leu Leu Leu Leu Thr Ala 
1               5                   10                  15      


His Leu Gly Pro Ser Glu Ala Gln His Trp Ser His Gly Trp Tyr Pro 
            20                  25                  30          


Gly Gly Lys Arg Ala Leu Ser Ser Ala Gln Asp Pro Gln Asn Ala Leu 
        35                  40                  45              


Arg Pro Pro Ala Gly Ser Pro Val Gln Thr Ala His Gly Leu Pro Ser 
    50                  55                  60                  


Asp Ala Leu Ala Pro Leu Asp Asp Ser Met Pro Trp Glu Gly Arg Thr 
65                  70                  75                  80  


Thr Ala Gln Trp Ser Leu His Arg Lys Arg His Leu Ala Arg Thr Leu 
                85                  90                  95      


Leu Thr Ala Ala Arg Glu Pro Arg Pro Ala Pro Pro Ser Ser Asn Lys 
            100                 105                 110         


Val 
    


<210>  6089
<211>  120
<212>  PRT
<213>  Homo Sapiens

<400>  6089

Met Ala Ser Ser Arg Arg Gly Leu Leu Leu Leu Leu Leu Leu Thr Ala 
1               5                   10                  15      


His Leu Gly Pro Ser Glu Ala Gln His Trp Ser His Gly Trp Tyr Pro 
            20                  25                  30          


Gly Gly Lys Arg Ala Leu Ser Ser Ala Gln Asp Pro Gln Asn Ala Leu 
        35                  40                  45              


Arg Pro Pro Gly Arg Ala Leu Asp Thr Ala Ala Gly Ser Pro Val Gln 
    50                  55                  60                  


Thr Ala His Gly Leu Pro Ser Asp Ala Leu Ala Pro Leu Asp Asp Ser 
65                  70                  75                  80  


Met Pro Trp Glu Gly Arg Thr Thr Ala Gln Trp Ser Leu His Arg Lys 
                85                  90                  95      


Arg His Leu Ala Arg Thr Leu Leu Thr Ala Ala Arg Glu Pro Arg Pro 
            100                 105                 110         


Ala Pro Pro Ser Ser Asn Lys Val 
        115                 120 


<210>  6090
<211>  112
<212>  PRT
<213>  Homo Sapiens

<400>  6090

Met Ala Ser Ser Arg Arg Gly Leu Leu Leu Leu Leu Leu Leu Thr Ala 
1               5                   10                  15      


His Leu Gly Pro Ser Glu Ala Gln His Trp Ser His Gly Trp Tyr Pro 
            20                  25                  30          


Gly Gly Lys Arg Ala Leu Ser Ser Ala Gln Asp Pro Gln Asn Ala Leu 
        35                  40                  45              


Arg Pro Pro Gly Ser Pro Val Gln Thr Ala His Gly Leu Pro Ser Asp 
    50                  55                  60                  


Ala Leu Ala Pro Leu Asp Asp Ser Met Pro Trp Glu Gly Arg Thr Thr 
65                  70                  75                  80  


Ala Gln Trp Ser Leu His Arg Lys Arg His Leu Ala Arg Thr Leu Leu 
                85                  90                  95      


Thr Ala Ala Arg Glu Pro Arg Pro Ala Pro Pro Ser Ser Asn Lys Val 
            100                 105                 110         


<210>  6091
<211>  496
<212>  PRT
<213>  Homo Sapiens

<400>  6091

Met Asp Asn Tyr Leu Leu Leu Gln Thr Pro Leu Lys Lys Thr Lys Ala 
1               5                   10                  15      


Leu Ile Gly Glu Met Gly Met Thr Phe Ser Ser Ala Tyr Val Pro Ser 
            20                  25                  30          


Ala Leu Cys Cys Pro Ser Arg Ala Ser Ile Leu Thr Gly Lys Tyr Pro 
        35                  40                  45              


His Asn His His Val Val Asn Asn Thr Leu Glu Gly Asn Cys Ser Ser 
    50                  55                  60                  


Lys Ser Trp Gln Lys Ile Gln Glu Pro Asn Thr Phe Pro Ala Ile Leu 
65                  70                  75                  80  


Arg Ser Met Cys Gly Tyr Gln Thr Phe Phe Ala Gly Lys Tyr Leu Asn 
                85                  90                  95      


Glu Tyr Gly Ala Pro Asp Ala Gly Gly Leu Glu His Val Pro Leu Gly 
            100                 105                 110         


Trp Ser Tyr Trp Tyr Ala Leu Glu Lys Asn Ser Lys Tyr Tyr Asn Tyr 
        115                 120                 125             


Thr Leu Ser Ile Asn Gly Lys Ala Arg Lys His Gly Glu Asn Tyr Ser 
    130                 135                 140                 


Val Asp Tyr Leu Thr Asp Val Leu Ala Asn Val Ser Leu Asp Phe Leu 
145                 150                 155                 160 


Asp Tyr Lys Ser Asn Phe Glu Pro Phe Phe Met Met Ile Ala Thr Pro 
                165                 170                 175     


Ala Pro His Ser Pro Trp Thr Ala Ala Pro Gln Tyr Gln Lys Ala Phe 
            180                 185                 190         


Gln Asn Val Phe Ala Pro Arg Asn Lys Asn Phe Asn Ile His Gly Thr 
        195                 200                 205             


Asn Lys His Trp Leu Ile Arg Gln Ala Lys Thr Pro Met Thr Asn Ser 
    210                 215                 220                 


Ser Ile Gln Phe Leu Asp Asn Ala Phe Arg Lys Arg Trp Gln Thr Leu 
225                 230                 235                 240 


Leu Ser Val Asp Asp Leu Val Glu Lys Leu Val Lys Arg Leu Glu Phe 
                245                 250                 255     


Thr Gly Glu Leu Asn Asn Thr Tyr Ile Phe Tyr Thr Ser Asp Asn Gly 
            260                 265                 270         


Tyr His Thr Gly Gln Phe Ser Leu Pro Ile Asp Lys Arg Gln Leu Tyr 
        275                 280                 285             


Glu Phe Asp Ile Lys Val Pro Leu Leu Val Arg Gly Pro Gly Ile Lys 
    290                 295                 300                 


Pro Asn Gln Thr Ser Lys Met Leu Val Ala Asn Ile Asp Leu Gly Pro 
305                 310                 315                 320 


Thr Ile Leu Asp Ile Ala Gly Tyr Asp Leu Asn Lys Thr Gln Met Asp 
                325                 330                 335     


Gly Met Ser Leu Leu Pro Ile Leu Arg Gly Ala Ser Asn Leu Thr Trp 
            340                 345                 350         


Arg Ser Asp Val Leu Val Glu Tyr Gln Gly Glu Gly Arg Asn Val Thr 
        355                 360                 365             


Asp Pro Thr Cys Pro Ser Leu Ser Pro Gly Val Ser Gln Cys Phe Pro 
    370                 375                 380                 


Asp Cys Val Cys Glu Asp Ala Tyr Asn Asn Thr Tyr Ala Cys Val Arg 
385                 390                 395                 400 


Thr Met Ser Ala Leu Trp Asn Leu Gln Tyr Cys Glu Phe Asp Asp Gln 
                405                 410                 415     


Glu Val Phe Val Glu Val Tyr Asn Leu Thr Ala Asp Pro Asp Gln Ile 
            420                 425                 430         


Thr Asn Ile Ala Lys Thr Ile Asp Pro Glu Leu Leu Gly Lys Met Asn 
        435                 440                 445             


Tyr Arg Leu Met Met Leu Gln Ser Cys Ser Gly Pro Thr Cys Arg Thr 
    450                 455                 460                 


Pro Gly Val Phe Asp Pro Gly Tyr Arg Phe Asp Pro Arg Leu Met Phe 
465                 470                 475                 480 


Ser Asn Arg Gly Ser Val Arg Thr Arg Arg Phe Ser Lys His Leu Leu 
                485                 490                 495     


<210>  6092
<211>  248
<212>  PRT
<213>  Homo Sapiens

<400>  6092

Met Gly Met Thr Phe Ser Ser Ala Tyr Val Pro Ser Ala Leu Cys Cys 
1               5                   10                  15      


Pro Ser Arg Ala Ser Ile Leu Thr Gly Lys Tyr Pro His Asn His His 
            20                  25                  30          


Val Val Asn Asn Thr Leu Glu Gly Asn Cys Ser Ser Lys Ser Trp Gln 
        35                  40                  45              


Lys Ile Gln Glu Pro Asn Thr Phe Pro Ala Ile Leu Arg Ser Met Cys 
    50                  55                  60                  


Gly Tyr Gln Thr Phe Phe Ala Gly Lys Tyr Leu Asn Glu Tyr Gly Ala 
65                  70                  75                  80  


Pro Asp Ala Gly Gly Leu Glu His Val Pro Leu Gly Trp Ser Tyr Trp 
                85                  90                  95      


Tyr Ala Leu Glu Lys Asn Ser Lys Tyr Tyr Asn Tyr Thr Leu Ser Ile 
            100                 105                 110         


Asn Gly Lys Ala Arg Lys His Gly Glu Asn Tyr Ser Val Asp Tyr Leu 
        115                 120                 125             


Thr Asp Val Leu Ala Asn Val Ser Leu Asp Phe Leu Asp Tyr Lys Ser 
    130                 135                 140                 


Asn Phe Glu Pro Phe Phe Met Met Ile Ala Thr Pro Ala Pro His Ser 
145                 150                 155                 160 


Pro Trp Thr Ala Ala Pro Gln Tyr Gln Lys Ala Phe Gln Asn Val Phe 
                165                 170                 175     


Ala Pro Arg Asn Lys Asn Phe Asn Ile His Gly Thr Asn Lys His Trp 
            180                 185                 190         


Leu Ile Arg Gln Ala Lys Thr Pro Met Thr Asn Ser Ser Ile Gln Phe 
        195                 200                 205             


Leu Asp Asn Ala Phe Arg Lys Arg Trp Gln Thr Leu Leu Ser Val Asp 
    210                 215                 220                 


Asp Leu Val Glu Lys Leu Val Lys Arg Leu Glu Phe Thr Gly Glu Leu 
225                 230                 235                 240 


Asn Asn Thr Tyr Ile Phe Tyr Thr 
                245             


<210>  6093
<211>  584
<212>  PRT
<213>  Homo Sapiens

<400>  6093

Met Arg Leu Leu Pro Leu Ala Pro Gly Arg Leu Arg Arg Gly Ser Pro 
1               5                   10                  15      


Arg His Leu Pro Ser Cys Ser Pro Ala Leu Leu Leu Leu Val Leu Gly 
            20                  25                  30          


Gly Cys Leu Gly Val Phe Gly Val Ala Ala Gly Thr Arg Arg Pro Asn 
        35                  40                  45              


Val Val Leu Leu Leu Thr Asp Asp Gln Asp Glu Val Leu Gly Gly Met 
    50                  55                  60                  


Ala Phe Ser Glu Tyr Ser Thr Thr Asn Cys Gln Thr Gly Leu Gln Gly 
65                  70                  75                  80  


Glu Glu Leu Gly Gln Glu His Leu Arg Thr Tyr Leu Glu Pro Ser Arg 
                85                  90                  95      


Thr Pro Leu Lys Lys Thr Lys Ala Leu Ile Gly Glu Met Gly Met Thr 
            100                 105                 110         


Phe Ser Ser Ala Tyr Val Pro Ser Ala Leu Cys Cys Pro Ser Arg Ala 
        115                 120                 125             


Ser Ile Leu Thr Gly Lys Tyr Pro His Asn His His Val Val Asn Asn 
    130                 135                 140                 


Thr Leu Glu Gly Asn Cys Ser Ser Lys Ser Trp Gln Lys Ile Gln Glu 
145                 150                 155                 160 


Pro Asn Thr Phe Pro Ala Ile Leu Arg Ser Met Cys Gly Tyr Gln Thr 
                165                 170                 175     


Phe Phe Ala Gly Lys Tyr Leu Asn Glu Tyr Gly Ala Pro Asp Ala Gly 
            180                 185                 190         


Gly Leu Glu His Val Pro Leu Gly Trp Ser Tyr Trp Tyr Ala Leu Glu 
        195                 200                 205             


Lys Asn Ser Lys Tyr Tyr Asn Tyr Thr Leu Ser Ile Asn Gly Lys Ala 
    210                 215                 220                 


Arg Lys His Gly Glu Asn Tyr Ser Val Asp Tyr Leu Thr Asp Val Leu 
225                 230                 235                 240 


Ala Asn Val Ser Leu Asp Phe Leu Asp Tyr Lys Ser Asn Phe Glu Pro 
                245                 250                 255     


Phe Phe Met Met Ile Ala Thr Pro Ala Pro His Ser Pro Trp Thr Ala 
            260                 265                 270         


Ala Pro Gln Tyr Gln Lys Ala Phe Gln Asn Val Phe Ala Pro Arg Asn 
        275                 280                 285             


Lys Asn Phe Asn Ile His Gly Thr Asn Lys His Trp Leu Ile Arg Gln 
    290                 295                 300                 


Ala Lys Thr Pro Met Thr Asn Ser Ser Ile Gln Phe Leu Asp Asn Ala 
305                 310                 315                 320 


Phe Arg Lys Arg Trp Gln Thr Leu Leu Ser Val Asp Asp Leu Val Glu 
                325                 330                 335     


Lys Leu Val Lys Arg Leu Glu Phe Thr Gly Glu Leu Asn Asn Thr Tyr 
            340                 345                 350         


Ile Phe Tyr Thr Ser Asp Asn Gly Tyr His Thr Gly Gln Phe Ser Leu 
        355                 360                 365             


Pro Ile Asp Lys Arg Gln Leu Tyr Glu Phe Asp Ile Lys Val Pro Leu 
    370                 375                 380                 


Leu Val Arg Gly Pro Gly Ile Lys Pro Asn Gln Thr Ser Lys Met Leu 
385                 390                 395                 400 


Val Ala Asn Ile Asp Leu Gly Pro Thr Ile Leu Asp Ile Ala Gly Tyr 
                405                 410                 415     


Asp Leu Asn Lys Thr Gln Met Asp Gly Met Ser Leu Leu Pro Ile Leu 
            420                 425                 430         


Arg Gly Ala Ser Asn Leu Thr Trp Arg Ser Asp Val Leu Val Glu Tyr 
        435                 440                 445             


Gln Gly Glu Gly Arg Asn Val Thr Asp Pro Thr Cys Pro Ser Leu Ser 
    450                 455                 460                 


Pro Gly Val Ser Gln Cys Phe Pro Asp Cys Val Cys Glu Asp Ala Tyr 
465                 470                 475                 480 


Asn Asn Thr Tyr Ala Cys Val Arg Thr Met Ser Ala Leu Trp Asn Leu 
                485                 490                 495     


Gln Tyr Cys Glu Phe Asp Asp Gln Glu Val Phe Val Glu Val Tyr Asn 
            500                 505                 510         


Leu Thr Ala Asp Pro Asp Gln Ile Thr Asn Ile Ala Lys Thr Ile Asp 
        515                 520                 525             


Pro Glu Leu Leu Gly Lys Met Asn Tyr Arg Leu Met Met Leu Gln Ser 
    530                 535                 540                 


Cys Ser Gly Pro Thr Cys Arg Thr Pro Gly Val Phe Asp Pro Gly Tyr 
545                 550                 555                 560 


Arg Phe Asp Pro Arg Leu Met Phe Ser Asn Arg Gly Ser Val Arg Thr 
                565                 570                 575     


Arg Arg Phe Ser Lys His Leu Leu 
            580                 


<210>  6094
<211>  552
<212>  PRT
<213>  Homo Sapiens

<400>  6094

Met Arg Leu Leu Pro Leu Ala Pro Gly Arg Leu Arg Arg Gly Ser Pro 
1               5                   10                  15      


Arg His Leu Pro Ser Cys Ser Pro Ala Leu Leu Leu Leu Val Leu Gly 
            20                  25                  30          


Gly Cys Leu Gly Val Phe Gly Val Ala Ala Gly Thr Arg Arg Pro Asn 
        35                  40                  45              


Val Val Leu Leu Leu Thr Asp Asp Gln Asp Glu Val Leu Gly Gly Met 
    50                  55                  60                  


Thr Pro Leu Lys Lys Thr Lys Ala Leu Ile Gly Glu Met Gly Met Thr 
65                  70                  75                  80  


Phe Ser Ser Ala Tyr Val Pro Ser Ala Leu Cys Cys Pro Ser Arg Ala 
                85                  90                  95      


Ser Ile Leu Thr Gly Lys Tyr Pro His Asn His His Val Val Asn Asn 
            100                 105                 110         


Thr Leu Glu Gly Asn Cys Ser Ser Lys Ser Trp Gln Lys Ile Gln Glu 
        115                 120                 125             


Pro Asn Thr Phe Pro Ala Ile Leu Arg Ser Met Cys Gly Tyr Gln Thr 
    130                 135                 140                 


Phe Phe Ala Gly Lys Tyr Leu Asn Glu Tyr Gly Ala Pro Asp Ala Gly 
145                 150                 155                 160 


Gly Leu Glu His Val Pro Leu Gly Trp Ser Tyr Trp Tyr Ala Leu Glu 
                165                 170                 175     


Lys Asn Ser Lys Tyr Tyr Asn Tyr Thr Leu Ser Ile Asn Gly Lys Ala 
            180                 185                 190         


Arg Lys His Gly Glu Asn Tyr Ser Val Asp Tyr Leu Thr Asp Val Leu 
        195                 200                 205             


Ala Asn Val Ser Leu Asp Phe Leu Asp Tyr Lys Ser Asn Phe Glu Pro 
    210                 215                 220                 


Phe Phe Met Met Ile Ala Thr Pro Ala Pro His Ser Pro Trp Thr Ala 
225                 230                 235                 240 


Ala Pro Gln Tyr Gln Lys Ala Phe Gln Asn Val Phe Ala Pro Arg Asn 
                245                 250                 255     


Lys Asn Phe Asn Ile His Gly Thr Asn Lys His Trp Leu Ile Arg Gln 
            260                 265                 270         


Ala Lys Thr Pro Met Thr Asn Ser Ser Ile Gln Phe Leu Asp Asn Ala 
        275                 280                 285             


Phe Arg Lys Arg Trp Gln Thr Leu Leu Ser Val Asp Asp Leu Val Glu 
    290                 295                 300                 


Lys Leu Val Lys Arg Leu Glu Phe Thr Gly Glu Leu Asn Asn Thr Tyr 
305                 310                 315                 320 


Ile Phe Tyr Thr Ser Asp Asn Gly Tyr His Thr Gly Gln Phe Ser Leu 
                325                 330                 335     


Pro Ile Asp Lys Arg Gln Leu Tyr Glu Phe Asp Ile Lys Val Pro Leu 
            340                 345                 350         


Leu Val Arg Gly Pro Gly Ile Lys Pro Asn Gln Thr Ser Lys Met Leu 
        355                 360                 365             


Val Ala Asn Ile Asp Leu Gly Pro Thr Ile Leu Asp Ile Ala Gly Tyr 
    370                 375                 380                 


Asp Leu Asn Lys Thr Gln Met Asp Gly Met Ser Leu Leu Pro Ile Leu 
385                 390                 395                 400 


Arg Gly Ala Ser Asn Leu Thr Trp Arg Ser Asp Val Leu Val Glu Tyr 
                405                 410                 415     


Gln Gly Glu Gly Arg Asn Val Thr Asp Pro Thr Cys Pro Ser Leu Ser 
            420                 425                 430         


Pro Gly Val Ser Gln Cys Phe Pro Asp Cys Val Cys Glu Asp Ala Tyr 
        435                 440                 445             


Asn Asn Thr Tyr Ala Cys Val Arg Thr Met Ser Ala Leu Trp Asn Leu 
    450                 455                 460                 


Gln Tyr Cys Glu Phe Asp Asp Gln Glu Val Phe Val Glu Val Tyr Asn 
465                 470                 475                 480 


Leu Thr Ala Asp Pro Asp Gln Ile Thr Asn Ile Ala Lys Thr Ile Asp 
                485                 490                 495     


Pro Glu Leu Leu Gly Lys Met Asn Tyr Arg Leu Met Met Leu Gln Ser 
            500                 505                 510         


Cys Ser Gly Pro Thr Cys Arg Thr Pro Gly Val Phe Asp Pro Gly Tyr 
        515                 520                 525             


Arg Phe Asp Pro Arg Leu Met Phe Ser Asn Arg Gly Ser Val Arg Thr 
    530                 535                 540                 


Arg Arg Phe Ser Lys His Leu Leu 
545                 550         


<210>  6095
<211>  532
<212>  PRT
<213>  Homo Sapiens

<400>  6095

Met Arg Leu Leu Pro Leu Ala Pro Gly Arg Leu Arg Arg Gly Ser Pro 
1               5                   10                  15      


Arg His Leu Pro Ser Cys Ser Pro Ala Leu Leu Leu Leu Val Leu Gly 
            20                  25                  30          


Gly Cys Leu Gly Val Phe Gly Val Ala Ala Gly Thr Arg Arg Pro Asn 
        35                  40                  45              


Val Val Leu Leu Leu Thr Asp Asp Gln Asp Glu Val Leu Gly Gly Met 
    50                  55                  60                  


Tyr Val Pro Ser Ala Leu Cys Cys Pro Ser Arg Ala Ser Ile Leu Thr 
65                  70                  75                  80  


Gly Lys Tyr Pro His Asn His His Val Val Asn Asn Thr Leu Glu Gly 
                85                  90                  95      


Asn Cys Ser Ser Lys Ser Trp Gln Lys Ile Gln Glu Pro Asn Thr Phe 
            100                 105                 110         


Pro Ala Ile Leu Arg Ser Met Cys Gly Tyr Gln Thr Phe Phe Ala Gly 
        115                 120                 125             


Lys Tyr Leu Asn Glu Tyr Gly Ala Pro Asp Ala Gly Gly Leu Glu His 
    130                 135                 140                 


Val Pro Leu Gly Trp Ser Tyr Trp Tyr Ala Leu Glu Lys Asn Ser Lys 
145                 150                 155                 160 


Tyr Tyr Asn Tyr Thr Leu Ser Ile Asn Gly Lys Ala Arg Lys His Gly 
                165                 170                 175     


Glu Asn Tyr Ser Val Asp Tyr Leu Thr Asp Val Leu Ala Asn Val Ser 
            180                 185                 190         


Leu Asp Phe Leu Asp Tyr Lys Ser Asn Phe Glu Pro Phe Phe Met Met 
        195                 200                 205             


Ile Ala Thr Pro Ala Pro His Ser Pro Trp Thr Ala Ala Pro Gln Tyr 
    210                 215                 220                 


Gln Lys Ala Phe Gln Asn Val Phe Ala Pro Arg Asn Lys Asn Phe Asn 
225                 230                 235                 240 


Ile His Gly Thr Asn Lys His Trp Leu Ile Arg Gln Ala Lys Thr Pro 
                245                 250                 255     


Met Thr Asn Ser Ser Ile Gln Phe Leu Asp Asn Ala Phe Arg Lys Arg 
            260                 265                 270         


Trp Gln Thr Leu Leu Ser Val Asp Asp Leu Val Glu Lys Leu Val Lys 
        275                 280                 285             


Arg Leu Glu Phe Thr Gly Glu Leu Asn Asn Thr Tyr Ile Phe Tyr Thr 
    290                 295                 300                 


Ser Asp Asn Gly Tyr His Thr Gly Gln Phe Ser Leu Pro Ile Asp Lys 
305                 310                 315                 320 


Arg Gln Leu Tyr Glu Phe Asp Ile Lys Val Pro Leu Leu Val Arg Gly 
                325                 330                 335     


Pro Gly Ile Lys Pro Asn Gln Thr Ser Lys Met Leu Val Ala Asn Ile 
            340                 345                 350         


Asp Leu Gly Pro Thr Ile Leu Asp Ile Ala Gly Tyr Asp Leu Asn Lys 
        355                 360                 365             


Thr Gln Met Asp Gly Met Ser Leu Leu Pro Ile Leu Arg Gly Ala Ser 
    370                 375                 380                 


Asn Leu Thr Trp Arg Ser Asp Val Leu Val Glu Tyr Gln Gly Glu Gly 
385                 390                 395                 400 


Arg Asn Val Thr Asp Pro Thr Cys Pro Ser Leu Ser Pro Gly Val Ser 
                405                 410                 415     


Gln Cys Phe Pro Asp Cys Val Cys Glu Asp Ala Tyr Asn Asn Thr Tyr 
            420                 425                 430         


Ala Cys Val Arg Thr Met Ser Ala Leu Trp Asn Leu Gln Tyr Cys Glu 
        435                 440                 445             


Phe Asp Asp Gln Glu Val Phe Val Glu Val Tyr Asn Leu Thr Ala Asp 
    450                 455                 460                 


Pro Asp Gln Ile Thr Asn Ile Ala Lys Thr Ile Asp Pro Glu Leu Leu 
465                 470                 475                 480 


Gly Lys Met Asn Tyr Arg Leu Met Met Leu Gln Ser Cys Ser Gly Pro 
                485                 490                 495     


Thr Cys Arg Thr Pro Gly Val Phe Asp Pro Gly Tyr Arg Phe Asp Pro 
            500                 505                 510         


Arg Leu Met Phe Ser Asn Arg Gly Ser Val Arg Thr Arg Arg Phe Ser 
        515                 520                 525             


Lys His Leu Leu 
    530         


<210>  6096
<211>  303
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6096

Xaa Tyr Asn Tyr Thr Leu Ser Ile Asn Gly Lys Ala Arg Lys His Gly 
1               5                   10                  15      


Glu Asn Tyr Ser Val Asp Tyr Leu Thr Asp Val Leu Ala Asn Val Ser 
            20                  25                  30          


Leu Asp Phe Leu Asp Tyr Lys Ser Asn Phe Glu Pro Phe Phe Met Met 
        35                  40                  45              


Ile Ala Thr Pro Ala Pro His Ser Pro Trp Thr Ala Ala Pro Gln Tyr 
    50                  55                  60                  


Gln Lys Ala Phe Gln Asn Val Phe Ala Pro Arg Asn Lys Asn Phe Asn 
65                  70                  75                  80  


Ile His Gly Thr Asn Lys His Trp Leu Ile Arg Gln Ala Lys Thr Pro 
                85                  90                  95      


Met Thr Asn Ser Ser Ile Gln Phe Leu Asp Asn Ala Phe Arg Lys Arg 
            100                 105                 110         


Trp Gln Thr Leu Leu Ser Val Asp Asp Leu Val Glu Lys Leu Val Lys 
        115                 120                 125             


Arg Leu Glu Phe Thr Gly Glu Leu Asn Asn Thr Tyr Ile Phe Tyr Thr 
    130                 135                 140                 


Ser Asp Asn Gly Tyr His Thr Gly Gln Phe Ser Leu Pro Ile Asp Lys 
145                 150                 155                 160 


Arg Gln Leu Tyr Glu Phe Asp Ile Lys Val Pro Leu Leu Val Arg Gly 
                165                 170                 175     


Pro Gly Ile Lys Pro Asn Gln Thr Ser Lys Arg Gly Ala Ser Asn Leu 
            180                 185                 190         


Thr Trp Arg Ser Asp Val Leu Val Glu Tyr Gln Gly Glu Gly Arg Asn 
        195                 200                 205             


Val Thr Asp Pro Thr Cys Pro Ser Leu Ser Pro Gly Val Ser Gln Cys 
    210                 215                 220                 


Phe Pro Asp Cys Val Cys Glu Asp Ala Tyr Asn Asn Thr Tyr Ala Cys 
225                 230                 235                 240 


Val Arg Thr Met Ser Ala Leu Trp Asn Leu Gln Tyr Cys Glu Phe Asp 
                245                 250                 255     


Asp Gln Glu Val Phe Val Glu Val Tyr Asn Leu Thr Ala Asp Pro Asp 
            260                 265                 270         


Gln Ile Thr Asn Ile Ala Lys Thr Ile Asp Pro Glu Leu Leu Gly Lys 
        275                 280                 285             


Met Asn Tyr Arg Leu Met Met Leu Gln Ser Cys Ser Gly Pro Thr 
    290                 295                 300             


<210>  6097
<211>  80
<212>  PRT
<213>  Homo Sapiens

<400>  6097

Met Met Gly Leu Gly Asn Gly Arg Arg Ser Met Lys Ser Pro Pro Leu 
1               5                   10                  15      


Val Leu Ala Ala Leu Val Ala Cys Ile Ile Val Leu Gly Phe Asn Tyr 
            20                  25                  30          


Trp Ile Ala Ser Ser Arg Ser Val Asp Leu Gln Thr Arg Ile Met Glu 
        35                  40                  45              


Leu Glu Gly Arg Val Arg Arg Ala Ala Ala Glu Arg Gly Ala Val Glu 
    50                  55                  60                  


Leu Lys Lys Asn Glu Phe Gln Gly Glu Leu Glu Lys Gln Arg Glu Gln 
65                  70                  75                  80  


<210>  6098
<211>  121
<212>  PRT
<213>  Homo Sapiens

<400>  6098

Met Met Gly Leu Gly Asn Gly Arg Arg Ser Met Lys Ser Pro Pro Leu 
1               5                   10                  15      


Val Leu Ala Ala Leu Val Ala Cys Ile Ile Val Leu Gly Phe Asn Tyr 
            20                  25                  30          


Trp Ile Ala Ser Ser Arg Ser Val Asp Leu Gln Thr Arg Ile Met Glu 
        35                  40                  45              


Leu Glu Gly Arg Val Arg Arg Ala Ala Ala Glu Arg Gly Ala Val Glu 
    50                  55                  60                  


Leu Lys Lys Asn Glu Phe Gln Gly Glu Leu Glu Lys Gln Arg Glu Gln 
65                  70                  75                  80  


Leu Asp Lys Ile Gln Ser Ser His Asn Phe Gln Leu Glu Ser Val Asn 
                85                  90                  95      


Lys Leu Tyr Gln Asp Glu Lys Ala Val Leu Val Asn Asn Ile Thr Thr 
            100                 105                 110         


Gly Glu Arg Leu Ile Arg Val Leu Gln 
        115                 120     


<210>  6099
<211>  401
<212>  PRT
<213>  Homo Sapiens

<400>  6099

Met Met Gly Leu Gly Asn Gly Arg Arg Ser Met Lys Ser Pro Pro Leu 
1               5                   10                  15      


Val Leu Ala Ala Leu Val Ala Cys Ile Ile Val Leu Gly Phe Asn Tyr 
            20                  25                  30          


Trp Ile Ala Ser Ser Arg Ser Val Asp Leu Gln Thr Arg Ile Met Glu 
        35                  40                  45              


Leu Glu Gly Arg Val Arg Arg Ala Ala Ala Glu Arg Gly Ala Val Glu 
    50                  55                  60                  


Leu Lys Lys Asn Glu Phe Gln Gly Glu Leu Glu Lys Gln Arg Glu Gln 
65                  70                  75                  80  


Leu Asp Lys Ile Gln Ser Ser His Asn Phe Gln Leu Glu Ser Val Asn 
                85                  90                  95      


Lys Leu Tyr Gln Asp Glu Lys Ala Val Leu Val Asn Asn Ile Thr Thr 
            100                 105                 110         


Gly Glu Arg Leu Ile Arg Val Leu Gln Asp Gln Leu Lys Thr Leu Gln 
        115                 120                 125             


Arg Asn Tyr Gly Arg Leu Gln Gln Asp Val Leu Gln Phe Gln Lys Asn 
    130                 135                 140                 


Gln Thr Asn Leu Glu Arg Lys Phe Ser Tyr Asp Leu Ser Gln Cys Ile 
145                 150                 155                 160 


Asn Gln Met Lys Glu Val Lys Glu Gln Cys Glu Glu Arg Ile Glu Glu 
                165                 170                 175     


Val Thr Lys Lys Gly Asn Glu Ala Val Ala Ser Arg Asp Leu Ser Glu 
            180                 185                 190         


Asn Asn Asp Gln Arg Gln Gln Leu Gln Ala Leu Ser Glu Pro Gln Pro 
        195                 200                 205             


Arg Leu Gln Ala Ala Gly Leu Pro His Thr Glu Val Pro Gln Gly Lys 
    210                 215                 220                 


Gly Asn Val Leu Gly Asn Ser Lys Ser Gln Thr Pro Ala Pro Ser Ser 
225                 230                 235                 240 


Glu Val Val Leu Asp Ser Lys Arg Gln Val Glu Lys Glu Glu Thr Asn 
                245                 250                 255     


Glu Ile Gln Val Val Asn Glu Glu Pro Gln Arg Asp Arg Leu Pro Gln 
            260                 265                 270         


Glu Pro Gly Arg Glu Gln Val Val Glu Asp Arg Pro Val Gly Gly Arg 
        275                 280                 285             


Gly Phe Gly Gly Ala Gly Glu Leu Gly Gln Thr Pro Gln Val Gln Ala 
    290                 295                 300                 


Ala Leu Ser Val Ser Gln Glu Asn Pro Glu Met Glu Gly Pro Glu Arg 
305                 310                 315                 320 


Asp Gln Leu Val Ile Pro Asp Gly Gln Glu Glu Glu Gln Glu Ala Ala 
                325                 330                 335     


Gly Glu Gly Arg Asn Gln Gln Lys Leu Arg Gly Glu Asp Asp Tyr Asn 
            340                 345                 350         


Met Asp Glu Asn Glu Ala Glu Ser Glu Thr Asp Lys Gln Ala Ala Leu 
        355                 360                 365             


Ala Gly Asn Asp Arg Asn Ile Asp Val Phe Asn Val Glu Asp Gln Lys 
    370                 375                 380                 


Arg Asp Thr Ile Asn Leu Leu Asp Gln Arg Glu Lys Arg Asn His Thr 
385                 390                 395                 400 


Leu 
    


<210>  6100
<211>  401
<212>  PRT
<213>  Homo Sapiens

<400>  6100

Met Met Gly Leu Gly Asn Gly Arg Arg Ser Met Lys Ser Pro Pro Leu 
1               5                   10                  15      


Val Leu Ala Ala Leu Val Ala Cys Ile Ile Val Leu Gly Phe Asn Tyr 
            20                  25                  30          


Trp Ile Ala Ser Ser Arg Ser Val Asp Leu Gln Thr Arg Ile Met Glu 
        35                  40                  45              


Leu Glu Gly Arg Val Arg Arg Ala Ala Ala Glu Arg Gly Ala Val Glu 
    50                  55                  60                  


Leu Lys Lys Asn Glu Phe Gln Gly Glu Leu Glu Lys Gln Arg Glu Gln 
65                  70                  75                  80  


Leu Asp Lys Ile Gln Ser Ser His Asn Phe Gln Leu Glu Ser Val Asn 
                85                  90                  95      


Lys Leu Tyr Gln Asp Glu Lys Ala Val Leu Val Asn Asn Ile Thr Thr 
            100                 105                 110         


Gly Glu Arg Leu Ile Arg Val Leu Gln Asp Gln Leu Lys Thr Leu Gln 
        115                 120                 125             


Arg Asn Tyr Gly Arg Leu Gln Gln Asp Val Leu Gln Phe Gln Lys Asn 
    130                 135                 140                 


Gln Thr Asn Leu Glu Arg Lys Phe Ser Tyr Asp Leu Ser Gln Cys Ile 
145                 150                 155                 160 


Asn Gln Met Lys Glu Val Lys Glu Gln Cys Glu Glu Arg Ile Glu Glu 
                165                 170                 175     


Val Thr Lys Lys Gly Asn Glu Ala Val Ala Ser Arg Asp Leu Ser Glu 
            180                 185                 190         


Asn Asn Asp Gln Arg Gln Gln Leu Gln Ala Leu Ser Glu Pro Gln Pro 
        195                 200                 205             


Arg Leu Gln Ala Ala Gly Leu Pro His Thr Glu Val Pro Gln Gly Lys 
    210                 215                 220                 


Gly Asn Val Leu Gly Asn Ser Lys Ser Gln Thr Pro Ala Pro Ser Ser 
225                 230                 235                 240 


Glu Val Val Leu Asp Ser Lys Arg Gln Val Glu Lys Glu Glu Thr Asn 
                245                 250                 255     


Glu Ile Gln Val Val Asn Glu Glu Pro Gln Arg Asp Arg Leu Pro Gln 
            260                 265                 270         


Glu Pro Gly Arg Glu Gln Val Val Glu Asp Arg Pro Val Gly Gly Arg 
        275                 280                 285             


Gly Phe Gly Gly Ala Gly Glu Leu Gly Gln Thr Pro Gln Val Gln Ala 
    290                 295                 300                 


Ala Leu Ser Val Ser Gln Glu Asn Pro Glu Met Glu Gly Pro Glu Arg 
305                 310                 315                 320 


Asp Gln Leu Val Ile Pro Asp Gly Gln Glu Glu Glu Gln Glu Ala Ala 
                325                 330                 335     


Gly Glu Gly Arg Asn Gln Gln Lys Leu Arg Gly Glu Asp Asp Tyr Asn 
            340                 345                 350         


Met Asp Glu Asn Glu Ala Glu Ser Glu Thr Asp Lys Gln Ala Ala Leu 
        355                 360                 365             


Ala Gly Asn Asp Arg Asn Ile Asp Val Phe Asn Val Glu Asp Gln Lys 
    370                 375                 380                 


Arg Asp Thr Ile Asn Leu Leu Asp Gln Arg Glu Lys Arg Asn His Thr 
385                 390                 395                 400 


Leu 
    


<210>  6101
<211>  105
<212>  PRT
<213>  Homo Sapiens

<400>  6101

Met Met Gly Leu Gly Asn Gly Arg Arg Ser Met Lys Ser Pro Pro Leu 
1               5                   10                  15      


Val Leu Ala Ala Leu Val Ala Cys Ile Ile Val Leu Gly Phe Asn Tyr 
            20                  25                  30          


Trp Ile Ala Ser Ser Arg Ser Val Asp Leu Gln Thr Arg Ile Met Glu 
        35                  40                  45              


Leu Glu Gly Arg Val Arg Arg Ala Ala Ala Glu Arg Gly Ala Val Glu 
    50                  55                  60                  


Leu Lys Lys Asn Glu Phe Gln Gly Glu Leu Glu Lys Gln Arg Glu Gln 
65                  70                  75                  80  


Leu Asp Lys Ile Gln Ser Ser His Asn Phe Gln Leu Glu Ser Val Asn 
                85                  90                  95      


Lys Leu Tyr Gln Asp Glu Lys Thr Ser 
            100                 105 


<210>  6102
<211>  246
<212>  PRT
<213>  Homo Sapiens

<400>  6102

Met Ser Trp Ala Ala Val Leu Ala Val Ala Ala Ala Arg Phe Gly His 
1               5                   10                  15      


Phe Trp Gly Cys Arg Trp Pro Gly Pro Met Ala Gln Gly Trp Ala Gly 
            20                  25                  30          


Phe Ser Glu Glu Glu Leu Arg Arg Leu Lys Gln Thr Lys Asp Pro Phe 
        35                  40                  45              


Glu Pro Gln Arg Arg Leu Pro Ala Lys Lys Ser Arg Gln Gln Leu Gln 
    50                  55                  60                  


Arg Glu Lys Ala Leu Val Glu Gln Ser Gln Lys Leu Gly Leu Gln Asp 
65                  70                  75                  80  


Gly Ser Thr Ser Leu Leu Pro Glu Gln Leu Leu Ser Ala Pro Lys Gln 
                85                  90                  95      


Arg Val Asn Val Gln Lys Pro Pro Phe Ser Ser Pro Thr Leu Pro Ser 
            100                 105                 110         


His Phe Thr Leu Thr Ser Pro Val Gly Asp Gly Gln Pro Gln Gly Ile 
        115                 120                 125             


Glu Ser Gln Pro Lys Glu Leu Gly Leu Glu Asn Ser His Asp Gly His 
    130                 135                 140                 


Asn Asn Val Glu Ile Leu Pro Pro Lys Pro Asp Cys Lys Leu Glu Lys 
145                 150                 155                 160 


Lys Lys Val Glu Leu Gln Glu Lys Ser Arg Trp Glu Val Leu Gln Gln 
                165                 170                 175     


Glu Gln Arg Leu Met Glu Glu Lys Asn Lys Arg Lys Lys Ala Leu Leu 
            180                 185                 190         


Ala Lys Ala Ile Ala Glu Arg Ser Lys Arg Thr Gln Ala Glu Thr Met 
        195                 200                 205             


Lys Leu Lys Arg Ile Gln Lys Glu Leu Gln Ala Leu Asp Asp Met Val 
    210                 215                 220                 


Ser Ala Asp Ile Gly Ile Leu Arg Asn Arg Ile Asp Gln Ala Ser Leu 
225                 230                 235                 240 


Asp Tyr Ser Tyr Ala Arg 
                245     


<210>  6103
<211>  394
<212>  PRT
<213>  Homo Sapiens

<400>  6103

Met Ser Trp Ala Ala Val Leu Ala Val Ala Ala Ala Arg Phe Gly His 
1               5                   10                  15      


Phe Trp Gly Cys Arg Trp Pro Gly Pro Met Ala Gln Gly Trp Ala Gly 
            20                  25                  30          


Phe Ser Glu Glu Glu Leu Arg Arg Leu Lys Gln Thr Lys Asp Pro Phe 
        35                  40                  45              


Glu Pro Gln Arg Arg Leu Pro Ala Lys Lys Ser Arg Gln Gln Leu Gln 
    50                  55                  60                  


Arg Glu Lys Ala Leu Val Glu Gln Ser Gln Lys Leu Gly Leu Gln Asp 
65                  70                  75                  80  


Gly Ser Thr Ser Leu Leu Pro Glu Gln Leu Leu Ser Ala Pro Lys Gln 
                85                  90                  95      


Arg Val Asn Val Gln Lys Pro Pro Phe Ser Ser Pro Thr Leu Pro Ser 
            100                 105                 110         


His Phe Thr Leu Thr Ser Pro Val Gly Asp Gly Gln Pro Gln Gly Ile 
        115                 120                 125             


Glu Ser Gln Pro Lys Glu Leu Gly Leu Glu Asn Ser His Asp Gly His 
    130                 135                 140                 


Asn Asn Val Glu Ile Leu Pro Pro Lys Pro Asp Cys Lys Leu Glu Lys 
145                 150                 155                 160 


Lys Lys Val Glu Leu Gln Glu Lys Ser Arg Trp Glu Val Leu Gln Gln 
                165                 170                 175     


Glu Gln Arg Leu Met Glu Glu Lys Asn Lys Arg Lys Lys Ala Leu Leu 
            180                 185                 190         


Ala Lys Ala Ile Ala Glu Arg Ser Lys Arg Thr Gln Ala Glu Thr Met 
        195                 200                 205             


Lys Leu Lys Arg Ile Gln Lys Glu Leu Gln Ala Leu Asp Asp Met Val 
    210                 215                 220                 


Ser Ala Asp Ile Gly Ile Leu Arg Asn Arg Ile Asp Gln Ala Ser Leu 
225                 230                 235                 240 


Asp Tyr Ser Tyr Ala Arg Lys Arg Phe Asp Arg Ala Glu Ala Glu Tyr 
                245                 250                 255     


Ile Ala Ala Lys Leu Asp Ile Gln Arg Lys Thr Glu Ile Lys Glu Gln 
            260                 265                 270         


Leu Thr Glu His Leu Cys Thr Ile Ile Gln Gln Asn Glu Leu Arg Lys 
        275                 280                 285             


Ala Lys Lys Leu Glu Glu Leu Met Gln Gln Leu Asp Val Glu Ala Asp 
    290                 295                 300                 


Glu Glu Thr Leu Glu Leu Glu Val Glu Val Glu Arg Leu Leu His Glu 
305                 310                 315                 320 


Gln Glu Val Glu Ser Arg Arg Pro Val Val Arg Leu Glu Arg Pro Phe 
                325                 330                 335     


Gln Pro Ala Glu Glu Ser Val Thr Leu Glu Phe Ala Lys Glu Asn Arg 
            340                 345                 350         


Lys Cys Gln Glu Gln Ala Val Ser Pro Lys Val Asp Asp Gln Cys Gly 
        355                 360                 365             


Asn Ser Ser Ser Ile Pro Phe Leu Ser Pro Asn Cys Pro Asn Gln Glu 
    370                 375                 380                 


Gly Asn Asp Ile Ser Ala Ala Leu Ala Thr 
385                 390                 


<210>  6104
<211>  126
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6104

Xaa Ser Trp Ala Ala Val Leu Ala Val Ala Ala Ala Arg Phe Gly His 
1               5                   10                  15      


Phe Trp Gly Cys Arg Trp Pro Gly Pro Met Ala Gln Gly Trp Ala Gly 
            20                  25                  30          


Phe Ser Glu Glu Glu Leu Arg Arg Leu Lys Gln Thr Lys Gly Tyr Lys 
        35                  40                  45              


Cys Pro Gly Leu Trp Ser Asp Ser Ser Arg Leu Met Arg Arg Gln Thr 
    50                  55                  60                  


Thr Lys Leu Cys Asp Ser Arg Tyr Cys Lys Asn Leu Leu Gln Arg Gln 
65                  70                  75                  80  


Glu Glu Pro His Ser Ala Gly Asp Trp Met Glu Leu Gly Lys Ile Ser 
                85                  90                  95      


Gln Ser Leu Cys Val Ser Arg Gly Ala Phe Ser Arg Thr Lys Glu Lys 
            100                 105                 110         


Ser Thr Lys Asp Met Asn Arg Tyr Phe Leu Glu Lys Glu Ile 
        115                 120                 125     


<210>  6105
<211>  59
<212>  PRT
<213>  Homo Sapiens

<400>  6105

Met Ala Leu Leu His Ser Gly Arg Val Leu Pro Gly Ile Ala Ala Ala 
1               5                   10                  15      


Phe His Pro Gly Leu Ala Ala Ala Ala Ser Ala Arg Ala Arg Gln Arg 
            20                  25                  30          


Pro Arg Leu Pro Gln Lys Ile Trp Thr Arg Asn Thr Cys Pro Leu Gly 
        35                  40                  45              


Asp Trp Leu Asn Phe Ala Arg His Leu Gln Asn 
    50                  55                  


<210>  6106
<211>  430
<212>  PRT
<213>  Homo Sapiens

<400>  6106

Met Ala Leu Leu His Ser Gly Arg Val Leu Pro Gly Ile Ala Ala Ala 
1               5                   10                  15      


Phe His Pro Gly Leu Ala Ala Ala Ala Ser Ala Arg Ala Ser Ser Trp 
            20                  25                  30          


Trp Thr His Val Glu Met Gly Pro Pro Asp Pro Ile Leu Gly Val Thr 
        35                  40                  45              


Glu Ala Phe Lys Arg Asp Thr Asn Ser Lys Lys Met Asn Leu Gly Val 
    50                  55                  60                  


Gly Ala Tyr Arg Asp Asp Asn Gly Lys Pro Tyr Val Leu Pro Ser Val 
65                  70                  75                  80  


Arg Lys Ala Glu Ala Gln Ile Ala Ala Lys Asn Leu Asp Lys Glu Tyr 
                85                  90                  95      


Leu Pro Ile Gly Gly Leu Ala Glu Phe Cys Lys Ala Ser Ala Glu Leu 
            100                 105                 110         


Ala Leu Gly Glu Asn Ser Glu Val Leu Lys Ser Gly Arg Phe Val Thr 
        115                 120                 125             


Val Gln Thr Ile Ser Gly Thr Gly Ala Leu Arg Ile Gly Ala Ser Phe 
    130                 135                 140                 


Leu Gln Arg Phe Phe Lys Phe Ser Arg Asp Val Phe Leu Pro Lys Pro 
145                 150                 155                 160 


Thr Trp Gly Asn His Thr Pro Ile Phe Arg Asp Ala Gly Met Gln Leu 
                165                 170                 175     


Gln Gly Tyr Arg Tyr Tyr Asp Pro Lys Thr Cys Gly Phe Asp Phe Thr 
            180                 185                 190         


Gly Ala Val Glu Asp Ile Ser Lys Ile Pro Glu Gln Ser Val Leu Leu 
        195                 200                 205             


Leu His Ala Cys Ala His Asn Pro Thr Gly Val Asp Pro Arg Pro Glu 
    210                 215                 220                 


Gln Trp Lys Glu Ile Ala Thr Val Val Lys Lys Arg Asn Leu Phe Ala 
225                 230                 235                 240 


Phe Phe Asp Met Ala Tyr Gln Gly Phe Ala Ser Gly Asp Gly Asp Lys 
                245                 250                 255     


Asp Ala Trp Ala Val Arg His Phe Ile Glu Gln Gly Ile Asn Val Cys 
            260                 265                 270         


Leu Cys Gln Ser Tyr Ala Lys Asn Met Gly Leu Tyr Gly Glu Arg Val 
        275                 280                 285             


Gly Ala Phe Thr Met Val Cys Lys Asp Ala Asp Glu Ala Lys Arg Val 
    290                 295                 300                 


Glu Ser Gln Leu Lys Ile Leu Ile Arg Pro Met Tyr Ser Asn Pro Pro 
305                 310                 315                 320 


Leu Asn Gly Ala Arg Ile Ala Ala Ala Ile Leu Asn Thr Pro Asp Leu 
                325                 330                 335     


Arg Lys Gln Trp Leu Gln Glu Val Lys Val Met Ala Asp Arg Ile Ile 
            340                 345                 350         


Gly Met Arg Thr Gln Leu Val Ser Asn Leu Lys Lys Glu Gly Ser Thr 
        355                 360                 365             


His Asn Trp Gln His Ile Thr Asp Gln Ile Gly Met Phe Cys Phe Thr 
    370                 375                 380                 


Gly Leu Lys Pro Glu Gln Val Glu Arg Leu Ile Lys Glu Phe Ser Ile 
385                 390                 395                 400 


Tyr Met Thr Lys Asp Gly Arg Ile Ser Val Ala Gly Val Thr Ser Ser 
                405                 410                 415     


Asn Val Gly Tyr Leu Ala His Ala Ile His Gln Val Thr Lys 
            420                 425                 430 


<210>  6107
<211>  387
<212>  PRT
<213>  Homo Sapiens

<400>  6107

Met Ala Leu Leu His Ser Gly Arg Val Leu Pro Gly Ile Ala Ala Ala 
1               5                   10                  15      


Phe His Pro Gly Leu Ala Ala Ala Ala Ser Ala Arg Ala Ser Ser Trp 
            20                  25                  30          


Trp Thr His Val Glu Met Gly Pro Pro Asp Pro Ile Leu Gly Val Thr 
        35                  40                  45              


Glu Ala Phe Lys Arg Asp Thr Asn Ser Lys Lys Met Asn Leu Gly Val 
    50                  55                  60                  


Gly Ala Tyr Arg Asp Asp Asn Gly Lys Pro Tyr Val Leu Pro Ser Val 
65                  70                  75                  80  


Arg Lys Phe Val Thr Val Gln Thr Ile Ser Gly Thr Gly Ala Leu Arg 
                85                  90                  95      


Ile Gly Ala Ser Phe Leu Gln Arg Phe Phe Lys Phe Ser Arg Asp Val 
            100                 105                 110         


Phe Leu Pro Lys Pro Thr Trp Gly Asn His Thr Pro Ile Phe Arg Asp 
        115                 120                 125             


Ala Gly Met Gln Leu Gln Gly Tyr Arg Tyr Tyr Asp Pro Lys Thr Cys 
    130                 135                 140                 


Gly Phe Asp Phe Thr Gly Ala Val Glu Asp Ile Ser Lys Ile Pro Glu 
145                 150                 155                 160 


Gln Ser Val Leu Leu Leu His Ala Cys Ala His Asn Pro Thr Gly Val 
                165                 170                 175     


Asp Pro Arg Pro Glu Gln Trp Lys Glu Ile Ala Thr Val Val Lys Lys 
            180                 185                 190         


Arg Asn Leu Phe Ala Phe Phe Asp Met Ala Tyr Gln Gly Phe Ala Ser 
        195                 200                 205             


Gly Asp Gly Asp Lys Asp Ala Trp Ala Val Arg His Phe Ile Glu Gln 
    210                 215                 220                 


Gly Ile Asn Val Cys Leu Cys Gln Ser Tyr Ala Lys Asn Met Gly Leu 
225                 230                 235                 240 


Tyr Gly Glu Arg Val Gly Ala Phe Thr Met Val Cys Lys Asp Ala Asp 
                245                 250                 255     


Glu Ala Lys Arg Val Glu Ser Gln Leu Lys Ile Leu Ile Arg Pro Met 
            260                 265                 270         


Tyr Ser Asn Pro Pro Leu Asn Gly Ala Arg Ile Ala Ala Ala Ile Leu 
        275                 280                 285             


Asn Thr Pro Asp Leu Arg Lys Gln Trp Leu Gln Glu Val Lys Val Met 
    290                 295                 300                 


Ala Asp Arg Ile Ile Gly Met Arg Thr Gln Leu Val Ser Asn Leu Lys 
305                 310                 315                 320 


Lys Glu Gly Ser Thr His Asn Trp Gln His Ile Thr Asp Gln Ile Gly 
                325                 330                 335     


Met Phe Cys Phe Thr Gly Leu Lys Pro Glu Gln Val Glu Arg Leu Ile 
            340                 345                 350         


Lys Glu Phe Ser Ile Tyr Met Thr Lys Asp Gly Arg Ile Ser Val Ala 
        355                 360                 365             


Gly Val Thr Ser Ser Asn Val Gly Tyr Leu Ala His Ala Ile His Gln 
    370                 375                 380                 


Val Thr Lys 
385         


<210>  6108
<211>  145
<212>  PRT
<213>  Homo Sapiens

<400>  6108

Met Pro His Leu Met Glu Arg Met Val Gly Ser Gly Leu Leu Trp Leu 
1               5                   10                  15      


Ala Leu Val Ser Cys Ile Leu Thr Gln Ala Ser Ala Val Gln Arg Asp 
            20                  25                  30          


Pro Ser Thr Val Glu Asp Lys Cys Glu Lys Ala Cys Arg Pro Glu Glu 
        35                  40                  45              


Glu Cys Leu Ala Leu Asn Ser Thr Trp Gly Cys Phe Cys Arg Gln Asp 
    50                  55                  60                  


Leu Asn Ser Ser Asp Val His Ser Leu Gln Pro Gln Leu Asp Cys Gly 
65                  70                  75                  80  


Pro Arg Glu Ile Lys Val Lys Val Asp Lys Cys Leu Leu Gly Gly Leu 
                85                  90                  95      


Gly Leu Gly Glu Glu Val Ile Ala Tyr Leu Arg Asp Pro Asn Cys Ser 
            100                 105                 110         


Ser Ile Leu Gln Thr Glu Glu Arg Asn Trp Val Ser Val Thr Ser Pro 
        115                 120                 125             


Val Gln Ala Ser Ala Cys Arg Asn Ile Leu Glu Arg Asn Gln Thr His 
    130                 135                 140                 


Ala 
145 


<210>  6109
<211>  387
<212>  PRT
<213>  Homo Sapiens

<400>  6109

Met Pro His Leu Met Glu Arg Met Val Gly Ser Gly Leu Leu Trp Leu 
1               5                   10                  15      


Ala Leu Val Ser Cys Ile Leu Thr Gln Ala Ser Ala Val Gln Arg Asp 
            20                  25                  30          


Pro Ser Thr Val Glu Asp Lys Cys Glu Lys Ala Cys Arg Pro Glu Glu 
        35                  40                  45              


Glu Cys Leu Ala Leu Asn Ser Thr Trp Gly Cys Phe Cys Arg Gln Asp 
    50                  55                  60                  


Leu Asn Ser Ser Asp Val His Ser Leu Gln Pro Gln Leu Asp Cys Gly 
65                  70                  75                  80  


Pro Arg Glu Ile Lys Val Lys Val Asp Lys Cys Leu Leu Gly Gly Leu 
                85                  90                  95      


Gly Leu Gly Glu Glu Val Ile Ala Tyr Leu Arg Asp Pro Asn Cys Ser 
            100                 105                 110         


Ser Ile Leu Gln Thr Glu Glu Arg Asn Trp Val Ser Val Thr Ser Pro 
        115                 120                 125             


Val Gln Ala Ser Ala Cys Arg Asn Ile Leu Glu Arg Asn Gln Thr His 
    130                 135                 140                 


Ala Ile Tyr Lys Asn Thr Leu Ser Leu Val Asn Asp Phe Ile Ile Arg 
145                 150                 155                 160 


Asp Thr Ile Leu Asn Ile Asn Phe Gln Cys Ala Tyr Pro Leu Asp Met 
                165                 170                 175     


Lys Val Ser Leu Gln Ala Ala Leu Gln Pro Ile Val Ser Ser Leu Asn 
            180                 185                 190         


Val Ser Val Asp Gly Asn Gly Glu Phe Ile Val Arg Met Ala Leu Phe 
        195                 200                 205             


Gln Asp Gln Asn Tyr Thr Asn Pro Tyr Glu Gly Asp Ala Val Glu Leu 
    210                 215                 220                 


Ser Val Glu Ser Val Leu Tyr Val Gly Ala Ile Leu Glu Gln Gly Asp 
225                 230                 235                 240 


Thr Ser Arg Phe Asn Leu Val Leu Arg Asn Cys Tyr Ala Thr Pro Thr 
                245                 250                 255     


Glu Asp Lys Ala Asp Leu Val Lys Tyr Phe Ile Ile Arg Asn Ser Cys 
            260                 265                 270         


Ser Asn Gln Arg Asp Ser Thr Ile His Val Glu Glu Asn Gly Gln Ser 
        275                 280                 285             


Ser Glu Ser Arg Phe Ser Val Gln Met Phe Met Phe Ala Gly His Tyr 
    290                 295                 300                 


Asp Leu Val Phe Leu His Cys Glu Ile His Leu Cys Asp Ser Leu Asn 
305                 310                 315                 320 


Glu Gln Cys Gln Pro Ser Cys Ser Arg Ser Gln Val Arg Ser Glu Val 
                325                 330                 335     


Pro Ala Ile Asp Leu Ala Arg Val Leu Asp Leu Gly Pro Ile Thr Arg 
            340                 345                 350         


Arg Gly Ala Gln Ser Pro Gly Val Met Asn Gly Thr Pro Ser Thr Ala 
        355                 360                 365             


Gly Phe Leu Val Ala Trp Pro Met Val Leu Leu Thr Val Leu Leu Ala 
    370                 375                 380                 


Trp Leu Phe 
385         


<210>  6110
<211>  163
<212>  PRT
<213>  Homo Sapiens

<400>  6110

Met Pro His Leu Met Glu Arg Met Val Gly Ser Gly Leu Leu Trp Leu 
1               5                   10                  15      


Ala Leu Val Ser Cys Ile Leu Thr Gln Ala Ser Ala Val Gln Arg Gly 
            20                  25                  30          


Glu Gly Gly Val Arg Met Ser Glu Thr Cys Val Gln Val His Arg Cys 
        35                  40                  45              


Gln Thr Asp Ala Pro Met Trp Leu Asn Gly Thr His Pro Ala Leu Gly 
    50                  55                  60                  


Asp Gly Ile Thr Asn His Thr Ala Cys Ala His Trp Ser Gly Asn Cys 
65                  70                  75                  80  


Cys Phe Trp Lys Thr Glu Val Leu Val Lys Ala Cys Pro Gly Gly Tyr 
                85                  90                  95      


His Val Tyr Arg Leu Glu Gly Thr Pro Trp Cys Asn Leu Arg Tyr Cys 
            100                 105                 110         


Thr Asp Pro Ser Thr Val Glu Asp Lys Cys Glu Lys Ala Cys Arg Pro 
        115                 120                 125             


Glu Glu Glu Cys Leu Ala Leu Asn Ser Thr Trp Gly Cys Phe Cys Arg 
    130                 135                 140                 


Gln Asp Leu Asn Ser Ser Asp Val His Ser Leu Gln Pro Gln Leu Asp 
145                 150                 155                 160 


Cys Gly Pro 
            


<210>  6111
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  6111

Met Pro His Leu Met Glu Arg Met Val Gly Ser Gly Leu Leu Trp Leu 
1               5                   10                  15      


Ala Leu Val Ser Cys Ile Leu Thr Gln Ala Ser Ala Val Gln Arg Gly 
            20                  25                  30          


Tyr Gly Asn Pro Ile Glu Ala Ser Ser Tyr Gly Leu Asp Leu Asp Cys 
        35                  40                  45              


Gly Ala Pro Gly Thr Pro Glu Ala His Val Cys Phe Asp Pro Cys Gln 
    50                  55                  60                  


Asn Tyr Thr Leu Leu Asp Glu Pro Phe Arg Ser Thr Glu Asn Ser Ala 
65                  70                  75                  80  


Gly Ser Gln Gly Cys Asp Lys Asn Met Ser Gly Trp Tyr Arg Phe Val 
                85                  90                  95      


Gly Glu Gly Gly Val Arg Met Ser Glu Thr Cys Val Gln Val His Arg 
            100                 105                 110         


Cys Gln Thr Asp Ala Pro Met Trp Leu Asn Gly Thr His Pro Ala Leu 
        115                 120                 125             


<210>  6112
<211>  534
<212>  PRT
<213>  Homo Sapiens

<400>  6112

Met Pro His Leu Met Glu Arg Met Val Gly Ser Gly Leu Leu Trp Leu 
1               5                   10                  15      


Ala Leu Val Ser Cys Ile Leu Thr Gln Ala Ser Ala Val Gln Arg Gly 
            20                  25                  30          


Tyr Gly Asn Pro Ile Glu Ala Ser Ser Tyr Gly Leu Asp Leu Asp Cys 
        35                  40                  45              


Gly Ala Pro Gly Thr Pro Glu Ala His Val Cys Phe Asp Pro Cys Gln 
    50                  55                  60                  


Asn Tyr Thr Leu Leu Asp Glu Pro Phe Arg Ser Thr Glu Asn Ser Ala 
65                  70                  75                  80  


Gly Ser Gln Gly Cys Asp Lys Asn Met Ser Gly Trp Tyr Arg Phe Val 
                85                  90                  95      


Gly Glu Gly Gly Val Arg Met Ser Glu Thr Cys Val Gln Val His Arg 
            100                 105                 110         


Cys Gln Thr Asp Ala Pro Met Trp Leu Asn Gly Thr His Pro Ala Leu 
        115                 120                 125             


Gly Asp Gly Ile Thr Asn His Thr Ala Cys Ala His Trp Ser Gly Asn 
    130                 135                 140                 


Cys Cys Phe Trp Lys Thr Glu Val Leu Val Lys Ala Cys Pro Gly Gly 
145                 150                 155                 160 


Tyr His Val Tyr Arg Leu Glu Gly Thr Pro Trp Cys Asn Leu Arg Tyr 
                165                 170                 175     


Cys Thr Asp Pro Ser Thr Val Glu Asp Lys Cys Glu Lys Ala Cys Arg 
            180                 185                 190         


Pro Glu Glu Glu Cys Leu Ala Leu Asn Ser Thr Trp Gly Cys Phe Cys 
        195                 200                 205             


Arg Gln Asp Leu Asn Ser Ser Asp Val His Ser Leu Gln Pro Gln Leu 
    210                 215                 220                 


Asp Cys Gly Pro Arg Glu Ile Lys Val Lys Val Asp Lys Cys Leu Leu 
225                 230                 235                 240 


Gly Gly Leu Gly Leu Gly Glu Glu Val Ile Ala Tyr Leu Arg Asp Pro 
                245                 250                 255     


Asn Cys Ser Ser Ile Leu Gln Thr Glu Glu Arg Asn Trp Val Ser Val 
            260                 265                 270         


Thr Ser Pro Val Gln Ala Ser Ala Cys Arg Asn Ile Leu Glu Arg Asn 
        275                 280                 285             


Gln Thr His Ala Ile Tyr Lys Asn Thr Leu Ser Leu Val Asn Asp Phe 
    290                 295                 300                 


Ile Ile Arg Asp Thr Ile Leu Asn Ile Asn Phe Gln Cys Ala Tyr Pro 
305                 310                 315                 320 


Leu Asp Met Lys Val Ser Leu Gln Ala Ala Leu Gln Pro Ile Val Ser 
                325                 330                 335     


Ser Leu Asn Val Ser Val Asp Gly Asn Gly Glu Phe Ile Val Arg Met 
            340                 345                 350         


Ala Leu Phe Gln Asp Gln Asn Tyr Thr Asn Pro Tyr Glu Gly Asp Ala 
        355                 360                 365             


Val Glu Leu Ser Val Glu Ser Val Leu Tyr Val Gly Ala Ile Leu Glu 
    370                 375                 380                 


Gln Gly Asp Thr Ser Arg Phe Asn Leu Val Leu Arg Asn Cys Tyr Ala 
385                 390                 395                 400 


Thr Pro Thr Glu Asp Lys Ala Asp Leu Val Lys Tyr Phe Ile Ile Arg 
                405                 410                 415     


Asn Ser Cys Ser Asn Gln Arg Asp Ser Thr Ile His Val Glu Glu Asn 
            420                 425                 430         


Gly Gln Ser Ser Glu Ser Arg Phe Ser Val Gln Met Phe Met Phe Ala 
        435                 440                 445             


Gly His Tyr Asp Leu Val Phe Leu His Cys Glu Ile His Leu Cys Asp 
    450                 455                 460                 


Ser Leu Asn Glu Gln Cys Gln Pro Ser Cys Ser Arg Ser Gln Val Arg 
465                 470                 475                 480 


Ser Glu Val Pro Ala Ile Asp Leu Ala Arg Val Leu Asp Leu Gly Pro 
                485                 490                 495     


Ile Thr Arg Arg Gly Ala Gln Ser Pro Gly Val Met Asn Gly Thr Pro 
            500                 505                 510         


Ser Thr Ala Gly Phe Leu Val Ala Trp Pro Met Val Leu Leu Thr Val 
        515                 520                 525             


Leu Leu Ala Trp Leu Phe 
    530                 


<210>  6113
<211>  537
<212>  PRT
<213>  Homo Sapiens

<400>  6113

Met Pro His Leu Met Glu Arg Met Val Gly Ser Gly Leu Leu Trp Leu 
1               5                   10                  15      


Ala Leu Val Ser Cys Ile Leu Thr Gln Ala Ser Ala Val Gln Arg Gly 
            20                  25                  30          


Tyr Gly Asn Pro Ile Glu Ala Ser Ser Tyr Gly Leu Asp Leu Asp Cys 
        35                  40                  45              


Gly Ala Pro Gly Thr Pro Glu Ala His Val Cys Phe Asp Pro Cys Gln 
    50                  55                  60                  


Asn Tyr Thr Leu Leu Asp Glu Pro Phe Arg Ser Thr Glu Asn Ser Ala 
65                  70                  75                  80  


Gly Ser Gln Gly Cys Asp Lys Asn Met Ser Gly Trp Tyr Arg Phe Val 
                85                  90                  95      


Gly Glu Gly Gly Val Arg Met Ser Glu Thr Cys Val Gln Val His Arg 
            100                 105                 110         


Cys Gln Thr Asp Ala Pro Met Trp Leu Asn Gly Thr His Pro Ala Leu 
        115                 120                 125             


Gly Asp Gly Ile Thr Asn His Thr Ala Cys Ala His Trp Ser Gly Asn 
    130                 135                 140                 


Cys Cys Phe Trp Lys Thr Glu Val Leu Val Lys Ala Cys Pro Gly Gly 
145                 150                 155                 160 


Tyr His Val Tyr Arg Leu Glu Gly Thr Pro Trp Cys Asn Leu Arg Tyr 
                165                 170                 175     


Cys Thr Val Pro Arg Asp Pro Ser Thr Val Glu Asp Lys Cys Glu Lys 
            180                 185                 190         


Ala Cys Arg Pro Glu Glu Glu Cys Leu Ala Leu Asn Ser Thr Trp Gly 
        195                 200                 205             


Cys Phe Cys Arg Gln Asp Leu Asn Ser Ser Asp Val His Ser Leu Gln 
    210                 215                 220                 


Pro Gln Leu Asp Cys Gly Pro Arg Glu Ile Lys Val Lys Val Asp Lys 
225                 230                 235                 240 


Cys Leu Leu Gly Gly Leu Gly Leu Gly Glu Glu Val Ile Ala Tyr Leu 
                245                 250                 255     


Arg Asp Pro Asn Cys Ser Ser Ile Leu Gln Thr Glu Glu Arg Asn Trp 
            260                 265                 270         


Val Ser Val Thr Ser Pro Val Gln Ala Ser Ala Cys Arg Asn Ile Leu 
        275                 280                 285             


Glu Arg Asn Gln Thr His Ala Ile Tyr Lys Asn Thr Leu Ser Leu Val 
    290                 295                 300                 


Asn Asp Phe Ile Ile Arg Asp Thr Ile Leu Asn Ile Asn Phe Gln Cys 
305                 310                 315                 320 


Ala Tyr Pro Leu Asp Met Lys Val Ser Leu Gln Ala Ala Leu Gln Pro 
                325                 330                 335     


Ile Val Ser Ser Leu Asn Val Ser Val Asp Gly Asn Gly Glu Phe Ile 
            340                 345                 350         


Val Arg Met Ala Leu Phe Gln Asp Gln Asn Tyr Thr Asn Pro Tyr Glu 
        355                 360                 365             


Gly Asp Ala Val Glu Leu Ser Val Glu Ser Val Leu Tyr Val Gly Ala 
    370                 375                 380                 


Ile Leu Glu Gln Gly Asp Thr Ser Arg Phe Asn Leu Val Leu Arg Asn 
385                 390                 395                 400 


Cys Tyr Ala Thr Pro Thr Glu Asp Lys Ala Asp Leu Val Lys Tyr Phe 
                405                 410                 415     


Ile Ile Arg Asn Ser Cys Ser Asn Gln Arg Asp Ser Thr Ile His Val 
            420                 425                 430         


Glu Glu Asn Gly Gln Ser Ser Glu Ser Arg Phe Ser Val Gln Met Phe 
        435                 440                 445             


Met Phe Ala Gly His Tyr Asp Leu Val Phe Leu His Cys Glu Ile His 
    450                 455                 460                 


Leu Cys Asp Ser Leu Asn Glu Gln Cys Gln Pro Ser Cys Ser Arg Ser 
465                 470                 475                 480 


Gln Val Arg Ser Glu Val Pro Ala Ile Asp Leu Ala Arg Val Leu Asp 
                485                 490                 495     


Leu Gly Pro Ile Thr Arg Arg Gly Ala Gln Ser Pro Gly Val Met Asn 
            500                 505                 510         


Gly Thr Pro Ser Thr Ala Gly Phe Leu Val Ala Trp Pro Met Val Leu 
        515                 520                 525             


Leu Thr Val Leu Leu Ala Trp Leu Phe 
    530                 535         


<210>  6114
<211>  390
<212>  PRT
<213>  Homo Sapiens

<400>  6114

Met Pro His Leu Met Glu Arg Met Val Gly Ser Gly Leu Leu Trp Leu 
1               5                   10                  15      


Ala Leu Val Ser Cys Ile Leu Thr Gln Ala Ser Ala Val Gln Arg Val 
            20                  25                  30          


Pro Arg Asp Pro Ser Thr Val Glu Asp Lys Cys Glu Lys Ala Cys Arg 
        35                  40                  45              


Pro Glu Glu Glu Cys Leu Ala Leu Asn Ser Thr Trp Gly Cys Phe Cys 
    50                  55                  60                  


Arg Gln Asp Leu Asn Ser Ser Asp Val His Ser Leu Gln Pro Gln Leu 
65                  70                  75                  80  


Asp Cys Gly Pro Arg Glu Ile Lys Val Lys Val Asp Lys Cys Leu Leu 
                85                  90                  95      


Gly Gly Leu Gly Leu Gly Glu Glu Val Ile Ala Tyr Leu Arg Asp Pro 
            100                 105                 110         


Asn Cys Ser Ser Ile Leu Gln Thr Glu Glu Arg Asn Trp Val Ser Val 
        115                 120                 125             


Thr Ser Pro Val Gln Ala Ser Ala Cys Arg Asn Ile Leu Glu Arg Asn 
    130                 135                 140                 


Gln Thr His Ala Ile Tyr Lys Asn Thr Leu Ser Leu Val Asn Asp Phe 
145                 150                 155                 160 


Ile Ile Arg Asp Thr Ile Leu Asn Ile Asn Phe Gln Cys Ala Tyr Pro 
                165                 170                 175     


Leu Asp Met Lys Val Ser Leu Gln Ala Ala Leu Gln Pro Ile Val Ser 
            180                 185                 190         


Ser Leu Asn Val Ser Val Asp Gly Asn Gly Glu Phe Ile Val Arg Met 
        195                 200                 205             


Ala Leu Phe Gln Asp Gln Asn Tyr Thr Asn Pro Tyr Glu Gly Asp Ala 
    210                 215                 220                 


Val Glu Leu Ser Val Glu Ser Val Leu Tyr Val Gly Ala Ile Leu Glu 
225                 230                 235                 240 


Gln Gly Asp Thr Ser Arg Phe Asn Leu Val Leu Arg Asn Cys Tyr Ala 
                245                 250                 255     


Thr Pro Thr Glu Asp Lys Ala Asp Leu Val Lys Tyr Phe Ile Ile Arg 
            260                 265                 270         


Asn Ser Cys Ser Asn Gln Arg Asp Ser Thr Ile His Val Glu Glu Asn 
        275                 280                 285             


Gly Gln Ser Ser Glu Ser Arg Phe Ser Val Gln Met Phe Met Phe Ala 
    290                 295                 300                 


Gly His Tyr Asp Leu Val Phe Leu His Cys Glu Ile His Leu Cys Asp 
305                 310                 315                 320 


Ser Leu Asn Glu Gln Cys Gln Pro Ser Cys Ser Arg Ser Gln Val Arg 
                325                 330                 335     


Ser Glu Val Pro Ala Ile Asp Leu Ala Arg Val Leu Asp Leu Gly Pro 
            340                 345                 350         


Ile Thr Arg Arg Gly Ala Gln Ser Pro Gly Val Met Asn Gly Thr Pro 
        355                 360                 365             


Ser Thr Ala Gly Phe Leu Val Ala Trp Pro Met Val Leu Leu Thr Val 
    370                 375                 380                 


Leu Leu Ala Trp Leu Phe 
385                 390 


<210>  6115
<211>  141
<212>  PRT
<213>  Homo Sapiens

<400>  6115

Met Ser Gly Trp Tyr Arg Phe Val Gly Glu Gly Gly Val Arg Met Ser 
1               5                   10                  15      


Glu Thr Cys Val Gln Val His Arg Cys Gln Thr Asp Ala Pro Met Trp 
            20                  25                  30          


Leu Asn Gly Thr His Pro Ala Leu Gly Asp Gly Ile Thr Asn His Thr 
        35                  40                  45              


Ala Cys Ala His Trp Ser Gly Asn Cys Cys Phe Trp Lys Thr Glu Val 
    50                  55                  60                  


Leu Val Lys Ala Cys Pro Gly Gly Tyr His Val Tyr Arg Leu Glu Gly 
65                  70                  75                  80  


Thr Pro Trp Cys Asn Leu Arg Tyr Cys Thr Asp Pro Ser Thr Val Glu 
                85                  90                  95      


Asp Lys Cys Glu Lys Ala Cys Arg Pro Glu Glu Glu Cys Leu Ala Leu 
            100                 105                 110         


Asn Ser Thr Trp Gly Cys Phe Cys Arg Gln Asp Leu Asn Ser Ser Asp 
        115                 120                 125             


Val His Ser Leu Gln Pro Gln Leu Asp Cys Gly Pro Arg 
    130                 135                 140     


<210>  6116
<211>  42
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6116

Xaa Glu Arg Met Val Gly Ser Gly Leu Leu Trp Leu Ala Leu Val Ser 
1               5                   10                  15      


Cys Ile Leu Thr Gln Ala Ser Ala Val Gln Arg Gly Lys Tyr Ser Ala 
            20                  25                  30          


His Leu Ala Ser Gln Met Ser Arg Lys Thr 
        35                  40          


<210>  6117
<211>  117
<212>  PRT
<213>  Homo Sapiens

<400>  6117

Met Lys Arg Ser Leu Ala Gly Arg Tyr Arg Cys Ser Tyr Gln Asn Gly 
1               5                   10                  15      


Ser Leu Trp Ser Leu Pro Ser Asp Gln Leu Glu Leu Val Ala Thr Gly 
            20                  25                  30          


Val Phe Ala Lys Pro Ser Leu Ser Ala Gln Pro Gly Pro Ala Val Ser 
        35                  40                  45              


Ser Gly Gly Asp Val Thr Leu Gln Cys Gln Thr Arg Tyr Gly Phe Asp 
    50                  55                  60                  


Gln Phe Ala Leu Tyr Lys Glu Gly Asp Pro Ala Pro Tyr Lys Asn Pro 
65                  70                  75                  80  


Glu Arg Trp Tyr Arg Ala Ser Phe Pro Ile Ile Thr Val Thr Ala Ala 
                85                  90                  95      


His Ser Gly Thr Tyr Arg Cys Tyr Ser Phe Ser Ser Arg Asp Pro Tyr 
            100                 105                 110         


Leu Trp Ser Ala Pro 
        115         


<210>  6118
<211>  321
<212>  PRT
<213>  Homo Sapiens

<400>  6118

Met Ser Pro Ser Pro Thr Ala Leu Phe Cys Leu Gly Leu Cys Leu Gly 
1               5                   10                  15      


Arg Val Pro Ala Gln Ser Gly Pro Leu Pro Lys Pro Ser Leu Gln Ala 
            20                  25                  30          


Leu Pro Ser Ser Leu Val Pro Leu Glu Lys Pro Val Thr Leu Arg Cys 
        35                  40                  45              


Gln Gly Pro Pro Gly Val Asp Leu Tyr Arg Leu Glu Lys Leu Ser Ser 
    50                  55                  60                  


Ser Arg Tyr Gln Asp Gln Ala Val Leu Phe Ile Pro Ala Met Lys Arg 
65                  70                  75                  80  


Ser Leu Ala Gly Arg Tyr Arg Cys Ser Tyr Gln Asn Gly Ser Leu Trp 
                85                  90                  95      


Ser Leu Pro Ser Asp Gln Leu Glu Leu Val Ala Thr Gly Val Phe Ala 
            100                 105                 110         


Lys Pro Ser Leu Ser Ala Gln Pro Gly Pro Ala Val Ser Ser Gly Gly 
        115                 120                 125             


Asp Val Thr Leu Gln Cys Gln Thr Arg Tyr Gly Phe Asp Gln Phe Ala 
    130                 135                 140                 


Leu Tyr Lys Glu Gly Asp Pro Ala Pro Tyr Lys Asn Pro Glu Arg Trp 
145                 150                 155                 160 


Tyr Arg Ala Ser Phe Pro Ile Ile Thr Val Thr Ala Ala His Ser Gly 
                165                 170                 175     


Thr Tyr Arg Cys Tyr Ser Phe Ser Ser Arg Asp Pro Tyr Leu Trp Ser 
            180                 185                 190         


Ala Pro Ser Asp Pro Leu Glu Leu Val Val Thr Glu Phe Ser Glu Ala 
        195                 200                 205             


Thr Ala Glu Leu Thr Val Ser Phe Thr Asn Glu Val Phe Thr Thr Glu 
    210                 215                 220                 


Thr Ser Arg Ser Ile Thr Ala Ser Pro Lys Glu Ser Asp Ser Pro Ala 
225                 230                 235                 240 


Gly Pro Ala Arg Gln Tyr Tyr Thr Lys Gly Asn Leu Val Arg Ile Cys 
                245                 250                 255     


Leu Gly Ala Val Ile Leu Ile Ile Leu Ala Gly Phe Leu Ala Glu Asp 
            260                 265                 270         


Trp His Ser Arg Arg Lys Arg Leu Arg His Arg Gly Arg Ala Val Gln 
        275                 280                 285             


Arg Pro Leu Pro Pro Leu Pro Pro Leu Pro Leu Thr Arg Lys Ser Asn 
    290                 295                 300                 


Gly Gly Gln Asp Gly Gly Arg Gln Asp Val His Ser Arg Gly Leu Cys 
305                 310                 315                 320 


Ser 
    


<210>  6119
<211>  620
<212>  PRT
<213>  Homo Sapiens

<400>  6119

Met Ser Pro Ser Pro Thr Ala Leu Phe Cys Leu Gly Leu Cys Leu Gly 
1               5                   10                  15      


Arg Val Pro Ala Gln Ser Gly Pro Leu Pro Lys Pro Ser Leu Gln Ala 
            20                  25                  30          


Leu Pro Ser Ser Leu Val Pro Leu Glu Lys Pro Val Thr Leu Arg Cys 
        35                  40                  45              


Gln Gly Pro Pro Gly Val Asp Leu Tyr Arg Leu Glu Lys Leu Ser Ser 
    50                  55                  60                  


Ser Arg Tyr Gln Asp Gln Ala Val Leu Phe Ile Pro Ala Met Lys Arg 
65                  70                  75                  80  


Ser Leu Ala Gly Arg Tyr Arg Cys Ser Tyr Gln Asn Gly Ser Leu Trp 
                85                  90                  95      


Ser Leu Pro Ser Asp Gln Leu Glu Leu Val Ala Thr Gly Val Phe Ala 
            100                 105                 110         


Lys Pro Ser Leu Ser Ala Gln Pro Gly Pro Ala Val Ser Ser Gly Gly 
        115                 120                 125             


Asp Val Thr Leu Gln Cys Gln Thr Arg Tyr Gly Phe Asp Gln Phe Ala 
    130                 135                 140                 


Leu Tyr Lys Glu Gly Asp Pro Ala Pro Tyr Lys Asn Pro Glu Arg Trp 
145                 150                 155                 160 


Tyr Arg Ala Ser Phe Pro Ile Ile Thr Val Thr Ala Ala His Ser Gly 
                165                 170                 175     


Thr Tyr Arg Cys Tyr Ser Phe Ser Ser Arg Asp Pro Tyr Leu Trp Ser 
            180                 185                 190         


Ala Pro Ser Asp Pro Leu Glu Leu Val Val Thr Gly Thr Ser Val Thr 
        195                 200                 205             


Pro Ser Arg Leu Pro Thr Glu Pro Pro Ser Pro Val Ala Glu Phe Ser 
    210                 215                 220                 


Glu Ala Thr Ala Glu Leu Thr Val Ser Phe Thr Asn Glu Val Phe Thr 
225                 230                 235                 240 


Thr Glu Thr Ser Arg Ser Ile Thr Ala Ser Pro Lys Glu Ser Asp Ser 
                245                 250                 255     


Pro Ala Gly Glu Ser Cys Pro Pro Val Leu His Gln Gly Gln Pro Gly 
            260                 265                 270         


Pro Asp Met Pro Arg Gly Cys Asp Pro Asn Asn Pro Gly Gly Val Ser 
        275                 280                 285             


Gly Arg Gly Leu Ala Gln Pro Glu Glu Ala Pro Ala Ala Gln Gly Gln 
    290                 295                 300                 


Gly Cys Ala Glu Ala Ala Ser Ala Pro Pro Ala Pro Pro Ala Asp Pro 
305                 310                 315                 320 


Glu Ile Lys Arg Gly Ser Gly Trp Arg Pro Thr Gly Cys Ser Gln Pro 
                325                 330                 335     


Arg Val Met Phe Met Thr Ala Glu Pro Gln Ala Arg Ser Tyr Pro Arg 
            340                 345                 350         


Glu Gly Ser Trp His Gly Arg Arg Leu Lys Asp Trp Arg Val Trp Ser 
        355                 360                 365             


Val Glu Ala Gly Gly Gln Arg Leu Gln Leu Trp Lys Arg Gly His Ala 
    370                 375                 380                 


Ala Ser Ser Trp Cys Ser Ile Arg Glu Pro Phe Gly Gln Cys Leu Ser 
385                 390                 395                 400 


Val Cys Leu Pro Leu Cys Leu Arg Ala Pro Ser Ile Trp Asp Gly Arg 
                405                 410                 415     


Asn Leu Trp Arg Pro His Pro Pro Pro Cys Thr Leu Trp Met Thr Trp 
            420                 425                 430         


Tyr Pro Gly Trp Thr Thr Tyr Trp Pro Leu Ser Ser Thr Ser Leu Ile 
        435                 440                 445             


Trp Ala Pro Asp Gly Ser Leu Arg Phe Pro Ala Leu Arg Val Asp Ser 
    450                 455                 460                 


Val Pro Ser Ser Val Gln Asn Pro Pro Val Leu Pro Phe Gly Pro Leu 
465                 470                 475                 480 


Cys Ser Cys Leu Val Phe Pro Arg Asn Ser His Pro His Ser Ile Ser 
                485                 490                 495     


His Cys Gly Leu Thr Asn Leu Leu Ser Ser Leu Arg Thr Gly Leu Ala 
            500                 505                 510         


Gly Ser Leu Gly Met Ser Phe Ile Phe Leu Ser Val Lys Leu Ala Arg 
        515                 520                 525             


Cys Pro Leu Pro Phe Thr Leu Glu Asn Lys Ile Ser Leu Cys Asn Met 
    530                 535                 540                 


Val Lys Pro His Leu Tyr Gln Gln Asn Lys Lys Thr Gln Lys Leu Ala 
545                 550                 555                 560 


Arg Cys Gly Gly Ala Ser Leu Tyr Ser Gln Gln Leu Arg Gly Leu Arg 
                565                 570                 575     


Trp Glu Asn Gly Leu Ser Leu Gly Gly Arg Gly Cys Ser Glu Leu Arg 
            580                 585                 590         


Ser His His Cys Thr Leu Ala Arg Val Thr Lys Pro Asp Phe Val Ser 
        595                 600                 605             


Lys Asn Thr Gly Met Asn Met Ser Ile Thr Leu Ile 
    610                 615                 620 


<210>  6120
<211>  339
<212>  PRT
<213>  Homo Sapiens

<400>  6120

Met Ser Pro Ser Pro Thr Ala Leu Phe Cys Leu Gly Leu Cys Leu Gly 
1               5                   10                  15      


Arg Val Pro Ala Gln Ser Gly Pro Leu Pro Lys Pro Ser Leu Gln Ala 
            20                  25                  30          


Leu Pro Ser Ser Leu Val Pro Leu Glu Lys Pro Val Thr Leu Arg Cys 
        35                  40                  45              


Gln Gly Pro Pro Gly Val Asp Leu Tyr Arg Leu Glu Lys Leu Ser Ser 
    50                  55                  60                  


Ser Arg Tyr Gln Asp Gln Ala Val Leu Phe Ile Pro Ala Met Lys Arg 
65                  70                  75                  80  


Ser Leu Ala Gly Arg Tyr Arg Cys Ser Tyr Gln Asn Gly Ser Leu Trp 
                85                  90                  95      


Ser Leu Pro Ser Asp Gln Leu Glu Leu Val Ala Thr Gly Val Phe Ala 
            100                 105                 110         


Lys Pro Ser Leu Ser Ala Gln Pro Gly Pro Ala Val Ser Ser Gly Gly 
        115                 120                 125             


Asp Val Thr Leu Gln Cys Gln Thr Arg Tyr Gly Phe Asp Gln Phe Ala 
    130                 135                 140                 


Leu Tyr Lys Glu Gly Asp Pro Ala Pro Tyr Lys Asn Pro Glu Arg Trp 
145                 150                 155                 160 


Tyr Arg Ala Ser Phe Pro Ile Ile Thr Val Thr Ala Ala His Ser Gly 
                165                 170                 175     


Thr Tyr Arg Cys Tyr Ser Phe Ser Ser Arg Asp Pro Tyr Leu Trp Ser 
            180                 185                 190         


Ala Pro Ser Asp Pro Leu Glu Leu Val Val Thr Gly Thr Ser Val Thr 
        195                 200                 205             


Pro Ser Arg Leu Pro Thr Glu Pro Pro Ser Pro Val Ala Glu Phe Ser 
    210                 215                 220                 


Glu Ala Thr Ala Glu Leu Thr Val Ser Phe Thr Asn Glu Val Phe Thr 
225                 230                 235                 240 


Thr Glu Thr Ser Arg Ser Ile Thr Ala Ser Pro Lys Glu Ser Asp Ser 
                245                 250                 255     


Pro Ala Gly Pro Ala Arg Gln Tyr Tyr Thr Lys Gly Asn Leu Val Arg 
            260                 265                 270         


Ile Cys Leu Gly Ala Val Ile Leu Ile Ile Leu Ala Gly Phe Leu Ala 
        275                 280                 285             


Glu Asp Trp His Ser Arg Arg Lys Arg Leu Arg His Arg Gly Arg Ala 
    290                 295                 300                 


Val Gln Arg Pro Leu Pro Pro Leu Pro Pro Leu Pro Leu Thr Arg Lys 
305                 310                 315                 320 


Ser Asn Gly Gly Gln Asp Gly Gly Arg Gln Asp Val His Ser Arg Gly 
                325                 330                 335     


Leu Cys Ser 
            


<210>  6121
<211>  134
<212>  PRT
<213>  Homo Sapiens

<400>  6121

Met Ser Ala Leu Arg Pro Leu Leu Leu Leu Leu Leu Pro Leu Cys Pro 
1               5                   10                  15      


Gly Pro Gly Pro Gly Pro Gly Ser Glu Ala Lys Val Thr Arg Ser Cys 
            20                  25                  30          


Ala Glu Thr Arg Gln Val Leu Gly Ala Arg Gly Tyr Ser Leu Asn Leu 
        35                  40                  45              


Ile Pro Pro Ala Leu Ile Ser Gly Glu His Leu Arg Val Cys Pro Gln 
    50                  55                  60                  


Glu Tyr Thr Cys Cys Ser Ser Glu Thr Glu Gln Arg Leu Ile Arg Glu 
65                  70                  75                  80  


Thr Glu Ala Thr Phe Arg Gly Leu Val Glu Asp Ser Gly Ser Phe Leu 
                85                  90                  95      


Val His Thr Leu Ala Ala Arg His Arg Lys Phe Asp Asp Asn Pro Asp 
            100                 105                 110         


Pro Gly Gly Cys Pro Ser Leu Cys Ala Gly Pro Gly Asp Trp Lys Lys 
        115                 120                 125             


Cys Gly Gln Arg Ser Ala 
    130                 


<210>  6122
<211>  579
<212>  PRT
<213>  Homo Sapiens

<400>  6122

Met Ser Ala Leu Arg Pro Leu Leu Leu Leu Leu Leu Pro Leu Cys Pro 
1               5                   10                  15      


Gly Pro Gly Pro Gly Pro Gly Ser Glu Ala Lys Val Thr Arg Ser Cys 
            20                  25                  30          


Ala Glu Thr Arg Gln Val Leu Gly Ala Arg Gly Tyr Ser Leu Asn Leu 
        35                  40                  45              


Ile Pro Pro Ala Leu Ile Ser Gly Glu His Leu Arg Val Cys Pro Gln 
    50                  55                  60                  


Glu Tyr Thr Cys Cys Ser Ser Glu Thr Glu Gln Arg Leu Ile Arg Glu 
65                  70                  75                  80  


Thr Glu Ala Thr Phe Arg Gly Leu Val Glu Asp Ser Gly Ser Phe Leu 
                85                  90                  95      


Val His Thr Leu Ala Ala Arg His Arg Lys Phe Asp Glu Phe Phe Leu 
            100                 105                 110         


Glu Met Leu Ser Val Ala Gln His Ser Leu Thr Gln Leu Phe Ser His 
        115                 120                 125             


Ser Tyr Gly Arg Leu Tyr Ala Gln His Ala Leu Ile Phe Asn Gly Leu 
    130                 135                 140                 


Phe Ser Arg Leu Arg Asp Phe Tyr Gly Glu Ser Gly Glu Gly Leu Asp 
145                 150                 155                 160 


Asp Thr Leu Ala Asp Phe Trp Ala Gln Leu Leu Glu Arg Val Phe Pro 
                165                 170                 175     


Leu Leu His Pro Gln Tyr Ser Phe Pro Pro Asp Tyr Leu Leu Cys Leu 
            180                 185                 190         


Ser Arg Leu Ala Ser Ser Thr Asp Gly Ser Leu Gln Pro Phe Gly Asp 
        195                 200                 205             


Ser Pro Arg Arg Leu Arg Leu Gln Ile Thr Arg Thr Leu Val Ala Ala 
    210                 215                 220                 


Arg Ala Phe Val Gln Gly Leu Glu Thr Gly Arg Asn Val Val Ser Glu 
225                 230                 235                 240 


Ala Leu Lys Val Pro Val Ser Glu Gly Cys Ser Gln Ala Leu Met Arg 
                245                 250                 255     


Leu Ile Gly Cys Pro Leu Cys Arg Gly Val Pro Ser Leu Met Pro Cys 
            260                 265                 270         


Gln Gly Phe Cys Leu Asn Val Val Arg Gly Cys Leu Ser Ser Arg Gly 
        275                 280                 285             


Leu Glu Pro Asp Trp Gly Asn Tyr Leu Asp Gly Leu Leu Ile Leu Ala 
    290                 295                 300                 


Asp Lys Leu Gln Gly Pro Phe Ser Phe Glu Leu Thr Ala Glu Ser Ile 
305                 310                 315                 320 


Gly Val Lys Ile Ser Glu Gly Leu Met Tyr Leu Gln Glu Asn Ser Ala 
                325                 330                 335     


Lys Val Ser Ala Gln Val Phe Gln Glu Cys Gly Pro Pro Asp Pro Val 
            340                 345                 350         


Pro Ala Arg Asn Arg Arg Ala Pro Pro Pro Arg Glu Glu Ala Gly Arg 
        355                 360                 365             


Leu Trp Ser Met Val Thr Glu Glu Glu Arg Pro Thr Thr Ala Ala Gly 
    370                 375                 380                 


Thr Asn Leu His Arg Leu Val Trp Glu Leu Arg Glu Arg Leu Ala Arg 
385                 390                 395                 400 


Met Arg Gly Phe Trp Ala Arg Leu Ser Leu Thr Val Cys Gly Asp Ser 
                405                 410                 415     


Arg Met Ala Ala Asp Ala Ser Leu Glu Ala Ala Pro Cys Trp Thr Gly 
            420                 425                 430         


Ala Gly Arg Gly Arg Tyr Leu Pro Pro Val Val Gly Gly Ser Pro Ala 
        435                 440                 445             


Glu Gln Val Asn Asn Pro Glu Leu Lys Val Asp Ala Ser Gly Pro Asp 
    450                 455                 460                 


Val Pro Thr Arg Arg Arg Arg Leu Gln Leu Arg Ala Ala Thr Ala Arg 
465                 470                 475                 480 


Met Lys Thr Ala Ala Leu Gly His Asp Leu Asp Gly Gln Asp Ala Asp 
                485                 490                 495     


Glu Asp Ala Ser Gly Ser Gly Gly Gly Gln Gln Tyr Ala Asp Asp Trp 
            500                 505                 510         


Met Ala Gly Ala Val Ala Pro Pro Ala Arg Pro Pro Arg Pro Pro Tyr 
        515                 520                 525             


Pro Pro Arg Arg Asp Gly Ser Gly Gly Lys Gly Gly Gly Gly Ser Ala 
    530                 535                 540                 


Arg Tyr Asn Gln Gly Arg Ser Arg Ser Gly Gly Ala Ser Ile Gly Phe 
545                 550                 555                 560 


His Thr Gln Thr Ile Leu Ile Leu Ser Leu Ser Ala Leu Ala Leu Leu 
                565                 570                 575     


Gly Pro Arg 
            


<210>  6123
<211>  320
<212>  PRT
<213>  Homo Sapiens

<400>  6123

Glu Thr Leu Glu Thr Leu Ile Lys Gln Ala Glu Asn Tyr Thr Ser Ile 
1               5                   10                  15      


Leu Phe Cys Ser Thr Tyr Arg Asn Met Ala Leu Glu Ala Ala Ala Ser 
            20                  25                  30          


Val Gln Glu Phe Phe Thr Asp Val Gly Leu Tyr Leu Phe Gly Ala Asp 
        35                  40                  45              


Val Asn Pro Glu Glu Phe Val Asn Arg Phe Phe Asp Ser Leu Phe Pro 
    50                  55                  60                  


Leu Val Tyr Asn His Leu Ile Asn Pro Gly Val Thr Asp Ser Ser Leu 
65                  70                  75                  80  


Glu Tyr Ser Glu Cys Ile Arg Met Ala Arg Arg Asp Val Ser Pro Phe 
                85                  90                  95      


Gly Asn Ile Pro Gln Arg Val Met Gly Gln Met Gly Arg Ser Leu Leu 
            100                 105                 110         


Pro Ser Arg Thr Phe Leu Gln Ala Leu Asn Leu Gly Ile Glu Val Ile 
        115                 120                 125             


Asn Thr Thr Asp Tyr Leu His Phe Ser Lys Glu Cys Ser Arg Ala Leu 
    130                 135                 140                 


Leu Lys Met Gln Tyr Cys Pro His Cys Gln Gly Leu Ala Leu Thr Lys 
145                 150                 155                 160 


Pro Cys Met Gly Tyr Cys Leu Asn Val Met Arg Gly Cys Leu Ala His 
                165                 170                 175     


Met Ala Glu Leu Asn Pro His Trp His Ala Tyr Ile Arg Ser Leu Glu 
            180                 185                 190         


Glu Leu Ser Asp Ala Met His Gly Thr Tyr Asp Ile Gly His Val Leu 
        195                 200                 205             


Leu Asn Phe His Leu Leu Val Asn Asp Ala Val Leu Gln Ala His Leu 
    210                 215                 220                 


Asn Gly Gln Lys Leu Leu Glu Gln Val Asn Arg Ile Cys Gly Arg Pro 
225                 230                 235                 240 


Val Arg Thr Pro Thr Gln Ser Pro Arg Cys Ser Phe Asp Gln Ser Lys 
                245                 250                 255     


Glu Lys His Gly Met Lys Thr Thr Thr Arg Asn Ser Glu Glu Thr Leu 
            260                 265                 270         


Ala Asn Arg Arg Lys Glu Phe Ile Asn Ser Leu Arg Leu Tyr Arg Ser 
        275                 280                 285             


Phe Tyr Gly Gly Leu Ala Asp Gln Leu Cys Ala Asn Glu Leu Ala Ala 
    290                 295                 300                 


Ala Asp Gly Leu Pro Cys Trp Asn Gly Glu Asp Ile Val Lys Arg Tyr 
305                 310                 315                 320 


<210>  6124
<211>  572
<212>  PRT
<213>  Homo Sapiens

<400>  6124

Met Asp Ala Gln Thr Trp Pro Val Gly Phe Arg Cys Leu Leu Leu Leu 
1               5                   10                  15      


Ala Leu Val Gly Ser Ala Arg Ser Glu Gly Val Gln Thr Cys Glu Glu 
            20                  25                  30          


Val Arg Lys Leu Phe Gln Trp Arg Leu Leu Gly Ala Val Arg Gly Leu 
        35                  40                  45              


Pro Asp Ser Pro Arg Ala Gly Pro Asp Leu Gln Val Cys Ile Ser Lys 
    50                  55                  60                  


Lys Pro Thr Cys Cys Thr Arg Lys Met Glu Glu Arg Tyr Gln Ile Ala 
65                  70                  75                  80  


Ala Arg Gln Asp Met Gln Gln Phe Leu Gln Thr Ser Ser Ser Thr Leu 
                85                  90                  95      


Lys Phe Leu Ile Ser Arg Asn Ala Ala Ala Phe Gln Glu Thr Leu Glu 
            100                 105                 110         


Thr Leu Ile Lys Gln Ala Glu Asn Tyr Thr Ser Ile Leu Phe Cys Ser 
        115                 120                 125             


Thr Tyr Arg Asn Met Ala Leu Glu Ala Ala Ala Ser Val Gln Glu Phe 
    130                 135                 140                 


Phe Thr Asp Val Gly Leu Tyr Leu Phe Gly Ala Asp Val Asn Pro Glu 
145                 150                 155                 160 


Glu Phe Val Asn Arg Phe Phe Asp Ser Leu Phe Pro Leu Val Tyr Asn 
                165                 170                 175     


His Leu Ile Asn Pro Gly Val Thr Asp Ser Ser Leu Glu Tyr Ser Glu 
            180                 185                 190         


Cys Ile Arg Met Ala Arg Arg Asp Val Ser Pro Phe Gly Asn Ile Pro 
        195                 200                 205             


Gln Arg Val Met Gly Gln Met Gly Arg Ser Leu Leu Pro Ser Arg Thr 
    210                 215                 220                 


Phe Leu Gln Ala Leu Asn Leu Gly Ile Glu Val Ile Asn Thr Thr Asp 
225                 230                 235                 240 


Tyr Leu His Phe Ser Lys Glu Cys Ser Arg Ala Leu Leu Lys Met Gln 
                245                 250                 255     


Tyr Cys Pro His Cys Gln Gly Leu Ala Leu Thr Lys Pro Cys Met Gly 
            260                 265                 270         


Tyr Cys Leu Asn Val Met Arg Gly Cys Leu Ala His Met Ala Glu Leu 
        275                 280                 285             


Asn Pro His Trp His Ala Tyr Ile Arg Ser Leu Glu Glu Leu Ser Asp 
    290                 295                 300                 


Ala Met His Gly Thr Tyr Asp Ile Gly His Val Leu Leu Asn Phe His 
305                 310                 315                 320 


Leu Leu Val Asn Asp Ala Val Leu Gln Ala His Leu Asn Gly Gln Lys 
                325                 330                 335     


Leu Leu Glu Gln Val Asn Arg Ile Cys Gly Arg Pro Val Arg Thr Pro 
            340                 345                 350         


Thr Gln Ser Pro Arg Cys Ser Phe Asp Gln Ser Lys Glu Lys His Gly 
        355                 360                 365             


Met Lys Thr Thr Thr Arg Asn Ser Glu Glu Thr Leu Ala Asn Arg Arg 
    370                 375                 380                 


Lys Glu Phe Ile Asn Ser Leu Arg Leu Tyr Arg Ser Phe Tyr Gly Gly 
385                 390                 395                 400 


Leu Ala Asp Gln Leu Cys Ala Asn Glu Leu Ala Ala Ala Asp Gly Leu 
                405                 410                 415     


Pro Cys Trp Asn Gly Glu Asp Ile Val Lys Ser Tyr Thr Gln Arg Val 
            420                 425                 430         


Val Gly Asn Gly Ile Lys Ala Gln Ser Gly Asn Pro Glu Val Lys Val 
        435                 440                 445             


Lys Gly Ile Asp Pro Val Ile Asn Gln Ile Ile Asp Lys Leu Lys His 
    450                 455                 460                 


Val Val Gln Leu Leu Gln Gly Arg Ser Pro Lys Pro Asp Lys Trp Glu 
465                 470                 475                 480 


Leu Leu Gln Leu Gly Ser Gly Gly Gly Met Val Glu Gln Val Ser Gly 
                485                 490                 495     


Asp Cys Asp Asp Glu Asp Gly Cys Gly Gly Ser Gly Ser Gly Glu Val 
            500                 505                 510         


Lys Arg Thr Leu Lys Ile Thr Asp Trp Met Pro Asp Asp Met Asn Phe 
        515                 520                 525             


Ser Asp Val Lys Gln Ile His Gln Thr Asp Thr Gly Ser Thr Leu Asp 
    530                 535                 540                 


Thr Thr Gly Ala Gly Cys Ala Val Ala Thr Glu Ser Met Thr Phe Thr 
545                 550                 555                 560 


Leu Ile Ser Val Val Met Leu Leu Pro Gly Ile Trp 
                565                 570         


<210>  6125
<211>  51
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6125

Xaa Met Pro Asp Asp Met Asn Phe Ser Asp Val Lys Gln Ile His Gln 
1               5                   10                  15      


Thr Asp Thr Gly Ser Thr Leu Asp Thr Thr Gly Ala Gly Cys Ala Val 
            20                  25                  30          


Ala Thr Glu Ser Met Thr Phe Thr Leu Ile Ser Val Val Met Leu Leu 
        35                  40                  45              


Pro Gly Ile 
    50      


<210>  6126
<211>  263
<212>  PRT
<213>  Homo Sapiens

<400>  6126

Asp Ala Met Leu Leu Val Ala Glu Arg Leu Glu Gly Pro Phe Asn Ile 
1               5                   10                  15      


Glu Ser Val Met Asp Pro Ile Asp Val Lys Ile Ser Glu Ala Ile Met 
            20                  25                  30          


Asn Met Gln Glu Asn Ser Met Gln Val Ser Ala Lys Val Phe Gln Gly 
        35                  40                  45              


Cys Gly Gln Pro Lys Pro Ala Pro Ala Leu Arg Ser Ala Arg Ser Ala 
    50                  55                  60                  


Pro Glu Asn Phe Asn Thr Arg Phe Arg Pro Tyr Asn Pro Glu Glu Arg 
65                  70                  75                  80  


Pro Thr Thr Ala Ala Gly Thr Ser Leu Asp Arg Leu Val Thr Asp Ile 
                85                  90                  95      


Lys Glu Lys Leu Lys Leu Ser Lys Lys Val Trp Ser Ala Leu Pro Tyr 
            100                 105                 110         


Thr Ile Cys Lys Asp Glu Ser Val Thr Ala Gly Thr Ser Asn Glu Glu 
        115                 120                 125             


Glu Cys Trp Asn Gly His Ser Lys Ala Arg Tyr Leu Pro Glu Ile Met 
    130                 135                 140                 


Asn Asp Gly Leu Thr Asn Gln Ile Asn Asn Pro Glu Val Asp Val Asp 
145                 150                 155                 160 


Ile Thr Arg Pro Asp Thr Phe Ile Arg Gln Gln Ile Met Ala Leu Arg 
                165                 170                 175     


Val Met Thr Asn Lys Leu Lys Asn Ala Tyr Asn Gly Asn Asp Val Asn 
            180                 185                 190         


Phe Gln Asp Thr Ser Asp Glu Ser Ser Gly Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Cys Met Asp Asp Val Cys Pro Thr Glu Phe Glu Phe Val Thr Thr Glu 
    210                 215                 220                 


Ala Pro Ala Val Asp Pro Asp Arg Arg Glu Val Asp Ser Ser Ala Ala 
225                 230                 235                 240 


Gln Arg Gly His Ser Leu Leu Ser Trp Ser Leu Thr Cys Ile Val Leu 
                245                 250                 255     


Ala Leu Gln Arg Leu Cys Arg 
            260             


<210>  6127
<211>  555
<212>  PRT
<213>  Homo Sapiens

<400>  6127

Met Pro Ser Trp Ile Gly Ala Val Ile Leu Pro Leu Leu Gly Leu Leu 
1               5                   10                  15      


Leu Ser Leu Pro Ala Gly Ala Asp Val Lys Ala Arg Ser Cys Gly Glu 
            20                  25                  30          


Val Arg Gln Ala Tyr Gly Ala Lys Gly Phe Ser Leu Ala Asp Ile Pro 
        35                  40                  45              


Tyr Gln Glu Ile Ala Gly Glu His Leu Arg Ile Cys Pro Gln Glu Tyr 
    50                  55                  60                  


Thr Cys Cys Thr Thr Glu Met Glu Asp Lys Leu Ser Gln Gln Ser Lys 
65                  70                  75                  80  


Leu Glu Phe Glu Asn Leu Val Glu Glu Thr Ser His Phe Val Arg Thr 
                85                  90                  95      


Thr Phe Val Ser Arg His Lys Lys Phe Asp Glu Phe Phe Arg Glu Leu 
            100                 105                 110         


Leu Glu Asn Ala Glu Lys Ser Leu Asn Asp Met Phe Val Arg Thr Tyr 
        115                 120                 125             


Gly Met Leu Tyr Met Gln Asn Ser Glu Val Phe Gln Asp Leu Phe Thr 
    130                 135                 140                 


Glu Leu Lys Arg Tyr Tyr Thr Gly Gly Asn Val Asn Leu Glu Glu Met 
145                 150                 155                 160 


Leu Asn Asp Phe Trp Ala Arg Leu Leu Glu Arg Met Phe Gln Leu Ile 
                165                 170                 175     


Asn Pro Gln Tyr His Phe Ser Glu Asp Tyr Leu Glu Cys Val Ser Lys 
            180                 185                 190         


Tyr Thr Asp Gln Leu Lys Pro Phe Gly Asp Val Pro Arg Lys Leu Lys 
        195                 200                 205             


Ile Gln Val Thr Arg Ala Phe Ile Ala Ala Arg Thr Phe Val Gln Gly 
    210                 215                 220                 


Leu Thr Val Gly Arg Glu Val Ala Asn Arg Val Ser Lys Val Ser Pro 
225                 230                 235                 240 


Thr Pro Gly Cys Ile Arg Ala Leu Met Lys Met Leu Tyr Cys Pro Tyr 
                245                 250                 255     


Cys Arg Gly Leu Pro Thr Val Arg Pro Cys Asn Asn Tyr Cys Leu Asn 
            260                 265                 270         


Val Met Lys Gly Cys Leu Ala Asn Gln Ala Asp Leu Asp Thr Glu Trp 
        275                 280                 285             


Asn Leu Phe Ile Asp Ala Met Leu Leu Val Ala Glu Arg Leu Glu Gly 
    290                 295                 300                 


Pro Phe Asn Ile Glu Ser Val Met Asp Pro Ile Asp Val Lys Ile Ser 
305                 310                 315                 320 


Glu Ala Ile Met Asn Met Gln Glu Asn Ser Met Gln Val Ser Ala Lys 
                325                 330                 335     


Val Phe Gln Gly Cys Gly Gln Pro Lys Pro Ala Pro Ala Leu Arg Ser 
            340                 345                 350         


Ala Arg Ser Ala Pro Glu Asn Phe Asn Thr Arg Phe Arg Pro Tyr Asn 
        355                 360                 365             


Pro Glu Glu Arg Pro Thr Thr Ala Ala Gly Thr Ser Leu Asp Arg Leu 
    370                 375                 380                 


Val Thr Asp Ile Lys Glu Lys Leu Lys Leu Ser Lys Lys Val Trp Ser 
385                 390                 395                 400 


Ala Leu Pro Tyr Thr Ile Cys Lys Asp Glu Ser Val Thr Ala Gly Thr 
                405                 410                 415     


Ser Asn Glu Glu Glu Cys Trp Asn Gly His Ser Lys Ala Arg Tyr Leu 
            420                 425                 430         


Pro Glu Ile Met Asn Asp Gly Leu Thr Asn Gln Ile Asn Asn Pro Glu 
        435                 440                 445             


Val Asp Val Asp Ile Thr Arg Pro Asp Thr Phe Ile Arg Gln Gln Ile 
    450                 455                 460                 


Met Ala Leu Arg Val Met Thr Asn Lys Leu Lys Asn Ala Tyr Asn Gly 
465                 470                 475                 480 


Asn Asp Val Asn Phe Gln Asp Thr Ser Asp Glu Ser Ser Gly Ser Gly 
                485                 490                 495     


Ser Gly Ser Gly Cys Met Asp Asp Val Cys Pro Thr Glu Phe Glu Phe 
            500                 505                 510         


Val Thr Thr Glu Ala Pro Ala Val Asp Pro Asp Arg Arg Glu Val Asp 
        515                 520                 525             


Ser Ser Ala Ala Gln Arg Gly His Ser Leu Leu Ser Trp Ser Leu Thr 
    530                 535                 540                 


Cys Ile Val Leu Ala Leu Gln Arg Leu Cys Arg 
545                 550                 555 


<210>  6128
<211>  109
<212>  PRT
<213>  Homo Sapiens

<400>  6128

Met Ala Phe Gln Lys Ala Val Lys Gly Thr Ile Leu Val Gly Gly Gly 
1               5                   10                  15      


Ala Leu Ala Thr Val Leu Gly Leu Ser Gln Phe Ala His Tyr Arg Arg 
            20                  25                  30          


Lys Gln Met Asn Leu Ala Tyr Val Lys Ala Ala Asp Cys Ile Ser Glu 
        35                  40                  45              


Pro Val Asn Arg Glu Pro Pro Ser Arg Glu Ala Gln Leu Leu Thr Leu 
    50                  55                  60                  


Gln Asn Thr Ser Glu Phe Asp Ile Leu Val Ile Gly Gly Gly Ala Thr 
65                  70                  75                  80  


Gly Ser Gly Cys Ala Leu Asp Ala Val Thr Arg Gly Leu Lys Thr Ala 
                85                  90                  95      


Leu Val Glu Arg Asp Asp Phe Ser Ser Gly Thr Ser Ser 
            100                 105                 


<210>  6129
<211>  727
<212>  PRT
<213>  Homo Sapiens

<400>  6129

Met Ala Phe Gln Lys Ala Val Lys Gly Thr Ile Leu Val Gly Gly Gly 
1               5                   10                  15      


Ala Leu Ala Thr Val Leu Gly Leu Ser Gln Phe Ala His Tyr Arg Arg 
            20                  25                  30          


Lys Gln Met Asn Leu Ala Tyr Val Lys Ala Ala Asp Cys Ile Ser Glu 
        35                  40                  45              


Pro Val Asn Arg Glu Pro Pro Ser Arg Glu Ala Gln Leu Leu Thr Leu 
    50                  55                  60                  


Gln Asn Thr Ser Glu Phe Asp Ile Leu Val Ile Gly Gly Gly Ala Thr 
65                  70                  75                  80  


Gly Ser Gly Cys Ala Leu Asp Ala Val Thr Arg Gly Leu Lys Thr Ala 
                85                  90                  95      


Leu Val Glu Arg Asp Asp Phe Ser Ser Gly Thr Ser Ser Arg Ser Thr 
            100                 105                 110         


Lys Leu Ile His Gly Gly Val Arg Tyr Leu Gln Lys Ala Ile Met Lys 
        115                 120                 125             


Leu Asp Ile Glu Gln Tyr Arg Met Val Lys Glu Ala Leu His Glu Arg 
    130                 135                 140                 


Ala Asn Leu Leu Glu Ile Ala Pro His Leu Ser Ala Pro Leu Pro Ile 
145                 150                 155                 160 


Met Leu Pro Val Tyr Lys Trp Trp Gln Leu Pro Tyr Tyr Trp Val Gly 
                165                 170                 175     


Ile Lys Leu Tyr Asp Leu Val Ala Gly Ser Asn Cys Leu Lys Ser Ser 
            180                 185                 190         


Tyr Val Leu Ser Lys Ser Arg Ala Leu Glu His Phe Pro Met Leu Gln 
        195                 200                 205             


Lys Asp Lys Leu Val Gly Ala Ile Val Tyr Tyr Asp Gly Gln His Asn 
    210                 215                 220                 


Asp Ala Arg Met Asn Leu Ala Ile Ala Leu Thr Ala Ala Arg Tyr Gly 
225                 230                 235                 240 


Ala Ala Thr Ala Asn Tyr Met Glu Val Val Ser Leu Leu Lys Lys Thr 
                245                 250                 255     


Asp Pro Gln Thr Gly Lys Val Arg Val Ser Gly Ala Arg Cys Lys Asp 
            260                 265                 270         


Val Leu Thr Gly Gln Glu Phe Asp Val Arg Ala Lys Cys Val Ile Asn 
        275                 280                 285             


Ala Thr Gly Pro Phe Thr Asp Ser Val Arg Lys Met Asp Asp Lys Asp 
    290                 295                 300                 


Ala Ala Ala Ile Cys Gln Pro Ser Ala Gly Val His Ile Val Met Pro 
305                 310                 315                 320 


Gly Tyr Tyr Ser Pro Glu Ser Met Gly Leu Leu Asp Pro Ala Thr Ser 
                325                 330                 335     


Asp Gly Arg Val Ile Phe Phe Leu Pro Trp Gln Lys Met Thr Ile Ala 
            340                 345                 350         


Gly Thr Thr Asp Thr Pro Thr Asp Val Thr His His Pro Ile Pro Ser 
        355                 360                 365             


Glu Glu Asp Ile Asn Phe Ile Leu Asn Glu Val Arg Asn Tyr Leu Ser 
    370                 375                 380                 


Cys Asp Val Glu Val Arg Arg Gly Asp Val Leu Ala Ala Trp Ser Gly 
385                 390                 395                 400 


Ile Arg Pro Leu Val Thr Asp Pro Lys Ser Ala Asp Thr Gln Ser Ile 
                405                 410                 415     


Ser Arg Asn His Val Val Asp Ile Ser Glu Ser Gly Leu Ile Thr Ile 
            420                 425                 430         


Ala Gly Gly Lys Trp Thr Thr Tyr Arg Ser Met Ala Glu Asp Thr Ile 
        435                 440                 445             


Asn Ala Ala Val Lys Thr His Asn Leu Lys Ala Gly Pro Ser Arg Thr 
    450                 455                 460                 


Val Gly Leu Phe Leu Gln Gly Gly Lys Asp Trp Ser Pro Thr Leu Tyr 
465                 470                 475                 480 


Ile Arg Leu Val Gln Asp Tyr Gly Leu Glu Ser Glu Val Ala Gln His 
                485                 490                 495     


Leu Ala Ala Thr Tyr Gly Asp Lys Ala Phe Glu Val Ala Lys Met Ala 
            500                 505                 510         


Ser Val Thr Gly Lys Arg Trp Pro Ile Val Gly Val Arg Leu Val Ser 
        515                 520                 525             


Glu Phe Pro Tyr Ile Glu Ala Glu Val Lys Tyr Gly Ile Lys Glu Tyr 
    530                 535                 540                 


Ala Cys Thr Ala Val Asp Met Ile Ser Arg Arg Thr Arg Leu Ala Phe 
545                 550                 555                 560 


Leu Asn Val Gln Ala Ala Glu Glu Ala Leu Pro Arg Ile Val Glu Leu 
                565                 570                 575     


Met Gly Arg Glu Leu Asn Trp Asp Asp Tyr Lys Lys Gln Glu Gln Leu 
            580                 585                 590         


Glu Thr Ala Arg Lys Phe Leu Tyr Tyr Glu Met Gly Tyr Lys Ser Arg 
        595                 600                 605             


Ser Glu Gln Leu Thr Asp Arg Ser Glu Ile Ser Leu Leu Pro Ser Asp 
    610                 615                 620                 


Ile Asp Arg Tyr Lys Lys Arg Phe His Lys Phe Asp Ala Asp Gln Lys 
625                 630                 635                 640 


Gly Phe Ile Thr Ile Val Asp Val Gln Arg Val Leu Glu Ser Ile Asn 
                645                 650                 655     


Val Gln Met Asp Glu Asn Thr Leu His Glu Ile Leu Asn Glu Val Asp 
            660                 665                 670         


Leu Asn Lys Asn Gly Gln Val Glu Leu Asn Glu Phe Leu Gln Leu Met 
        675                 680                 685             


Ser Ala Ile Gln Lys Gly Arg Val Ser Gly Ser Arg Leu Ala Ile Leu 
    690                 695                 700                 


Met Lys Thr Ala Glu Glu Asn Leu Asp Arg Arg Val Pro Ile Pro Val 
705                 710                 715                 720 


Asp Arg Ser Cys Gly Gly Leu 
                725         


<210>  6130
<211>  727
<212>  PRT
<213>  Homo Sapiens

<400>  6130

Met Ala Phe Gln Lys Ala Val Lys Gly Thr Ile Leu Val Gly Gly Gly 
1               5                   10                  15      


Ala Leu Ala Thr Val Leu Gly Leu Ser Gln Phe Ala His Tyr Arg Arg 
            20                  25                  30          


Lys Gln Met Asn Leu Ala Tyr Val Lys Ala Ala Asp Cys Ile Ser Glu 
        35                  40                  45              


Pro Val Asn Arg Glu Pro Pro Ser Arg Glu Ala Gln Leu Leu Thr Leu 
    50                  55                  60                  


Gln Asn Thr Ser Glu Phe Asp Ile Leu Val Ile Gly Gly Gly Ala Thr 
65                  70                  75                  80  


Gly Ser Gly Cys Ala Leu Asp Ala Val Thr Arg Gly Leu Lys Thr Ala 
                85                  90                  95      


Leu Val Glu Arg Asp Asp Phe Ser Ser Gly Thr Ser Ser Arg Ser Thr 
            100                 105                 110         


Lys Leu Ile His Gly Gly Val Arg Tyr Leu Gln Lys Ala Ile Met Lys 
        115                 120                 125             


Leu Asp Ile Glu Gln Tyr Arg Met Val Lys Glu Ala Leu His Glu Arg 
    130                 135                 140                 


Ala Asn Leu Leu Glu Ile Ala Pro His Leu Ser Ala Pro Leu Pro Ile 
145                 150                 155                 160 


Met Leu Pro Val Tyr Lys Trp Trp Gln Leu Pro Tyr Tyr Trp Val Gly 
                165                 170                 175     


Ile Lys Leu Tyr Asp Leu Val Ala Gly Ser Asn Cys Leu Lys Ser Ser 
            180                 185                 190         


Tyr Val Leu Ser Lys Ser Arg Ala Leu Glu His Phe Pro Met Leu Gln 
        195                 200                 205             


Lys Asp Lys Leu Val Gly Ala Ile Val Tyr Tyr Asp Gly Gln His Asn 
    210                 215                 220                 


Asp Ala Arg Met Asn Leu Ala Ile Ala Leu Thr Ala Ala Arg Tyr Gly 
225                 230                 235                 240 


Ala Ala Thr Ala Asn Tyr Met Glu Val Val Ser Leu Leu Lys Lys Thr 
                245                 250                 255     


Asp Pro Gln Thr Gly Lys Val Arg Val Ser Gly Ala Arg Cys Lys Asp 
            260                 265                 270         


Val Leu Thr Gly Gln Glu Phe Asp Val Arg Ala Lys Cys Val Ile Asn 
        275                 280                 285             


Ala Thr Gly Pro Phe Thr Asp Ser Val Arg Lys Met Asp Asp Lys Asp 
    290                 295                 300                 


Ala Ala Ala Ile Cys Gln Pro Ser Ala Gly Val His Ile Val Met Pro 
305                 310                 315                 320 


Gly Tyr Tyr Ser Pro Glu Ser Met Gly Leu Leu Asp Pro Ala Thr Ser 
                325                 330                 335     


Asp Gly Arg Val Ile Phe Phe Leu Pro Trp Gln Lys Met Thr Ile Ala 
            340                 345                 350         


Gly Thr Thr Asp Thr Pro Thr Asp Val Thr His His Pro Ile Pro Ser 
        355                 360                 365             


Glu Glu Asp Ile Asn Phe Ile Leu Asn Glu Val Arg Asn Tyr Leu Ser 
    370                 375                 380                 


Cys Asp Val Glu Val Arg Arg Gly Asp Val Leu Ala Ala Trp Ser Gly 
385                 390                 395                 400 


Ile Arg Pro Leu Val Thr Asp Pro Lys Ser Ala Asp Thr Gln Ser Ile 
                405                 410                 415     


Ser Arg Asn His Val Val Asp Ile Ser Glu Ser Gly Leu Ile Thr Ile 
            420                 425                 430         


Ala Gly Gly Lys Trp Thr Thr Tyr Arg Ser Met Ala Glu Asp Thr Ile 
        435                 440                 445             


Asn Ala Ala Val Lys Thr His Asn Leu Lys Ala Gly Pro Ser Arg Thr 
    450                 455                 460                 


Val Gly Leu Phe Leu Gln Gly Gly Lys Asp Trp Ser Pro Thr Leu Tyr 
465                 470                 475                 480 


Ile Arg Leu Val Gln Asp Tyr Gly Leu Glu Ser Glu Val Ala Gln His 
                485                 490                 495     


Leu Ala Ala Thr Tyr Gly Asp Lys Ala Phe Glu Val Ala Lys Met Ala 
            500                 505                 510         


Ser Val Thr Gly Lys Arg Trp Pro Ile Val Gly Val Arg Leu Val Ser 
        515                 520                 525             


Glu Phe Pro Tyr Ile Glu Ala Glu Val Lys Tyr Gly Ile Lys Glu Tyr 
    530                 535                 540                 


Ala Cys Thr Ala Val Asp Met Ile Ser Arg Arg Thr Arg Leu Ala Phe 
545                 550                 555                 560 


Leu Asn Val Gln Ala Ala Glu Glu Ala Leu Pro Arg Ile Val Glu Leu 
                565                 570                 575     


Met Gly Arg Glu Leu Asn Trp Asp Asp Tyr Lys Lys Gln Glu Gln Leu 
            580                 585                 590         


Glu Thr Ala Arg Lys Phe Leu Tyr Tyr Glu Met Gly Tyr Lys Ser Arg 
        595                 600                 605             


Ser Glu Gln Leu Thr Asp Arg Ser Glu Ile Ser Leu Leu Pro Ser Asp 
    610                 615                 620                 


Ile Asp Arg Tyr Lys Lys Arg Phe His Lys Phe Asp Ala Asp Gln Lys 
625                 630                 635                 640 


Gly Phe Ile Thr Ile Val Asp Val Gln Arg Val Leu Glu Ser Ile Asn 
                645                 650                 655     


Val Gln Met Asp Glu Asn Thr Leu His Glu Ile Leu Asn Glu Val Asp 
            660                 665                 670         


Leu Asn Lys Asn Gly Gln Val Glu Leu Asn Glu Phe Leu Gln Leu Met 
        675                 680                 685             


Ser Ala Ile Gln Lys Gly Arg Val Ser Gly Ser Arg Leu Ala Ile Leu 
    690                 695                 700                 


Met Lys Thr Ala Glu Glu Asn Leu Asp Arg Arg Val Pro Ile Pro Val 
705                 710                 715                 720 


Asp Arg Ser Cys Gly Gly Leu 
                725         


<210>  6131
<211>  727
<212>  PRT
<213>  Homo Sapiens

<400>  6131

Met Ala Phe Gln Lys Ala Val Lys Gly Thr Ile Leu Val Gly Gly Gly 
1               5                   10                  15      


Ala Leu Ala Thr Val Leu Gly Leu Ser Gln Phe Ala His Tyr Arg Arg 
            20                  25                  30          


Lys Gln Met Asn Leu Ala Tyr Val Lys Ala Ala Asp Cys Ile Ser Glu 
        35                  40                  45              


Pro Val Asn Arg Glu Pro Pro Ser Arg Glu Ala Gln Leu Leu Thr Leu 
    50                  55                  60                  


Gln Asn Thr Ser Glu Phe Asp Ile Leu Val Ile Gly Gly Gly Ala Thr 
65                  70                  75                  80  


Gly Ser Gly Cys Ala Leu Asp Ala Val Thr Arg Gly Leu Lys Thr Ala 
                85                  90                  95      


Leu Val Glu Arg Asp Asp Phe Ser Ser Gly Thr Ser Ser Arg Ser Thr 
            100                 105                 110         


Lys Leu Ile His Gly Gly Val Arg Tyr Leu Gln Lys Ala Ile Met Lys 
        115                 120                 125             


Leu Asp Ile Glu Gln Tyr Arg Met Val Lys Glu Ala Leu His Glu Arg 
    130                 135                 140                 


Ala Asn Leu Leu Glu Ile Ala Pro His Leu Ser Ala Pro Leu Pro Ile 
145                 150                 155                 160 


Met Leu Pro Val Tyr Lys Trp Trp Gln Leu Pro Tyr Tyr Trp Val Gly 
                165                 170                 175     


Ile Lys Leu Tyr Asp Leu Val Ala Gly Ser Asn Cys Leu Lys Ser Ser 
            180                 185                 190         


Tyr Val Leu Ser Lys Ser Arg Ala Leu Glu His Phe Pro Met Leu Gln 
        195                 200                 205             


Lys Asp Lys Leu Val Gly Ala Ile Val Tyr Tyr Asp Gly Gln His Asn 
    210                 215                 220                 


Asp Ala Arg Met Asn Leu Ala Ile Ala Leu Thr Ala Ala Arg Tyr Gly 
225                 230                 235                 240 


Ala Ala Thr Ala Asn Tyr Met Glu Val Val Ser Leu Leu Lys Lys Thr 
                245                 250                 255     


Asp Pro Gln Thr Gly Lys Val Arg Val Ser Gly Ala Arg Cys Lys Asp 
            260                 265                 270         


Val Leu Thr Gly Gln Glu Phe Asp Val Arg Ala Lys Cys Val Ile Asn 
        275                 280                 285             


Ala Thr Gly Pro Phe Thr Asp Ser Val Arg Lys Met Asp Asp Lys Asp 
    290                 295                 300                 


Ala Ala Ala Ile Cys Gln Pro Ser Ala Gly Val His Ile Val Met Pro 
305                 310                 315                 320 


Gly Tyr Tyr Ser Pro Glu Ser Met Gly Leu Leu Asp Pro Ala Thr Ser 
                325                 330                 335     


Asp Gly Arg Val Ile Phe Phe Leu Pro Trp Gln Lys Met Thr Ile Ala 
            340                 345                 350         


Gly Thr Thr Asp Thr Pro Thr Asp Val Thr His His Pro Ile Pro Ser 
        355                 360                 365             


Glu Glu Asp Ile Asn Phe Ile Leu Asn Glu Val Arg Asn Tyr Leu Ser 
    370                 375                 380                 


Cys Asp Val Glu Val Arg Arg Gly Asp Val Leu Ala Ala Trp Ser Gly 
385                 390                 395                 400 


Ile Arg Pro Leu Val Thr Asp Pro Lys Ser Ala Asp Thr Gln Ser Ile 
                405                 410                 415     


Ser Arg Asn His Val Val Asp Ile Ser Glu Ser Gly Leu Ile Thr Ile 
            420                 425                 430         


Ala Gly Gly Lys Trp Thr Thr Tyr Arg Ser Met Ala Glu Asp Thr Ile 
        435                 440                 445             


Asn Ala Ala Val Lys Thr His Asn Leu Lys Ala Gly Pro Ser Arg Thr 
    450                 455                 460                 


Val Gly Leu Phe Leu Gln Gly Gly Lys Asp Trp Ser Pro Thr Leu Tyr 
465                 470                 475                 480 


Ile Arg Leu Val Gln Asp Tyr Gly Leu Glu Ser Glu Val Ala Gln His 
                485                 490                 495     


Leu Ala Ala Thr Tyr Gly Asp Lys Ala Phe Glu Val Ala Lys Met Ala 
            500                 505                 510         


Ser Val Thr Gly Lys Arg Trp Pro Ile Val Gly Val Arg Leu Val Ser 
        515                 520                 525             


Glu Phe Pro Tyr Ile Glu Ala Glu Val Lys Tyr Gly Ile Lys Glu Tyr 
    530                 535                 540                 


Ala Cys Thr Ala Val Asp Met Ile Ser Arg Arg Thr Arg Leu Ala Phe 
545                 550                 555                 560 


Leu Asn Val Gln Ala Ala Glu Glu Ala Leu Pro Arg Ile Val Glu Leu 
                565                 570                 575     


Met Gly Arg Glu Leu Asn Trp Asp Asp Tyr Lys Lys Gln Glu Gln Leu 
            580                 585                 590         


Glu Thr Ala Arg Lys Phe Leu Tyr Tyr Glu Met Gly Tyr Lys Ser Arg 
        595                 600                 605             


Ser Glu Gln Leu Thr Asp Arg Ser Glu Ile Ser Leu Leu Pro Ser Asp 
    610                 615                 620                 


Ile Asp Arg Tyr Lys Lys Arg Phe His Lys Phe Asp Ala Asp Gln Lys 
625                 630                 635                 640 


Gly Phe Ile Thr Ile Val Asp Val Gln Arg Val Leu Glu Ser Ile Asn 
                645                 650                 655     


Val Gln Met Asp Glu Asn Thr Leu His Glu Ile Leu Asn Glu Val Asp 
            660                 665                 670         


Leu Asn Lys Asn Gly Gln Val Glu Leu Asn Glu Phe Leu Gln Leu Met 
        675                 680                 685             


Ser Ala Ile Gln Lys Gly Arg Val Ser Gly Ser Arg Leu Ala Ile Leu 
    690                 695                 700                 


Met Lys Thr Ala Glu Glu Asn Leu Asp Arg Arg Val Pro Ile Pro Val 
705                 710                 715                 720 


Asp Arg Ser Cys Gly Gly Leu 
                725         


<210>  6132
<211>  727
<212>  PRT
<213>  Homo Sapiens

<400>  6132

Met Ala Phe Gln Lys Ala Val Lys Gly Thr Ile Leu Val Gly Gly Gly 
1               5                   10                  15      


Ala Leu Ala Thr Val Leu Gly Leu Ser Gln Phe Ala His Tyr Arg Arg 
            20                  25                  30          


Lys Gln Met Asn Leu Ala Tyr Val Lys Ala Ala Asp Cys Ile Ser Glu 
        35                  40                  45              


Pro Val Asn Arg Glu Pro Pro Ser Arg Glu Ala Gln Leu Leu Thr Leu 
    50                  55                  60                  


Gln Asn Thr Ser Glu Phe Asp Ile Leu Val Ile Gly Gly Gly Ala Thr 
65                  70                  75                  80  


Gly Ser Gly Cys Ala Leu Asp Ala Val Thr Arg Gly Leu Lys Thr Ala 
                85                  90                  95      


Leu Val Glu Arg Asp Asp Phe Ser Ser Gly Thr Ser Ser Arg Ser Thr 
            100                 105                 110         


Lys Leu Ile His Gly Gly Val Arg Tyr Leu Gln Lys Ala Ile Met Lys 
        115                 120                 125             


Leu Asp Ile Glu Gln Tyr Arg Met Val Lys Glu Ala Leu His Glu Arg 
    130                 135                 140                 


Ala Asn Leu Leu Glu Ile Ala Pro His Leu Ser Ala Pro Leu Pro Ile 
145                 150                 155                 160 


Met Leu Pro Val Tyr Lys Trp Trp Gln Leu Pro Tyr Tyr Trp Val Gly 
                165                 170                 175     


Ile Lys Leu Tyr Asp Leu Val Ala Gly Ser Asn Cys Leu Lys Ser Ser 
            180                 185                 190         


Tyr Val Leu Ser Lys Ser Arg Ala Leu Glu His Phe Pro Met Leu Gln 
        195                 200                 205             


Lys Asp Lys Leu Val Gly Ala Ile Val Tyr Tyr Asp Gly Gln His Asn 
    210                 215                 220                 


Asp Ala Arg Met Asn Leu Ala Ile Ala Leu Thr Ala Ala Arg Tyr Gly 
225                 230                 235                 240 


Ala Ala Thr Ala Asn Tyr Met Glu Val Val Ser Leu Leu Lys Lys Thr 
                245                 250                 255     


Asp Pro Gln Thr Gly Lys Val Arg Val Ser Gly Ala Arg Cys Lys Asp 
            260                 265                 270         


Val Leu Thr Gly Gln Glu Phe Asp Val Arg Ala Lys Cys Val Ile Asn 
        275                 280                 285             


Ala Thr Gly Pro Phe Thr Asp Ser Val Arg Lys Met Asp Asp Lys Asp 
    290                 295                 300                 


Ala Ala Ala Ile Cys Gln Pro Ser Ala Gly Val His Ile Val Met Pro 
305                 310                 315                 320 


Gly Tyr Tyr Ser Pro Glu Ser Met Gly Leu Leu Asp Pro Ala Thr Ser 
                325                 330                 335     


Asp Gly Arg Val Ile Phe Phe Leu Pro Trp Gln Lys Met Thr Ile Ala 
            340                 345                 350         


Gly Thr Thr Asp Thr Pro Thr Asp Val Thr His His Pro Ile Pro Ser 
        355                 360                 365             


Glu Glu Asp Ile Asn Phe Ile Leu Asn Glu Val Arg Asn Tyr Leu Ser 
    370                 375                 380                 


Cys Asp Val Glu Val Arg Arg Gly Asp Val Leu Ala Ala Trp Ser Gly 
385                 390                 395                 400 


Ile Arg Pro Leu Val Thr Asp Pro Lys Ser Ala Asp Thr Gln Ser Ile 
                405                 410                 415     


Ser Arg Asn His Val Val Asp Ile Ser Glu Ser Gly Leu Ile Thr Ile 
            420                 425                 430         


Ala Gly Gly Lys Trp Thr Thr Tyr Arg Ser Met Ala Glu Asp Thr Ile 
        435                 440                 445             


Asn Ala Ala Val Lys Thr His Asn Leu Lys Ala Gly Pro Ser Arg Thr 
    450                 455                 460                 


Val Gly Leu Phe Leu Gln Gly Gly Lys Asp Trp Ser Pro Thr Leu Tyr 
465                 470                 475                 480 


Ile Arg Leu Val Gln Asp Tyr Gly Leu Glu Ser Glu Val Ala Gln His 
                485                 490                 495     


Leu Ala Ala Thr Tyr Gly Asp Lys Ala Phe Glu Val Ala Lys Met Ala 
            500                 505                 510         


Ser Val Thr Gly Lys Arg Trp Pro Ile Val Gly Val Arg Leu Val Ser 
        515                 520                 525             


Glu Phe Pro Tyr Ile Glu Ala Glu Val Lys Tyr Gly Ile Lys Glu Tyr 
    530                 535                 540                 


Ala Cys Thr Ala Val Asp Met Ile Ser Arg Arg Thr Arg Leu Ala Phe 
545                 550                 555                 560 


Leu Asn Val Gln Ala Ala Glu Glu Ala Leu Pro Arg Ile Val Glu Leu 
                565                 570                 575     


Met Gly Arg Glu Leu Asn Trp Asp Asp Tyr Lys Lys Gln Glu Gln Leu 
            580                 585                 590         


Glu Thr Ala Arg Lys Phe Leu Tyr Tyr Glu Met Gly Tyr Lys Ser Arg 
        595                 600                 605             


Ser Glu Gln Leu Thr Asp Arg Ser Glu Ile Ser Leu Leu Pro Ser Asp 
    610                 615                 620                 


Ile Asp Arg Tyr Lys Lys Arg Phe His Lys Phe Asp Ala Asp Gln Lys 
625                 630                 635                 640 


Gly Phe Ile Thr Ile Val Asp Val Gln Arg Val Leu Glu Ser Ile Asn 
                645                 650                 655     


Val Gln Met Asp Glu Asn Thr Leu His Glu Ile Leu Asn Glu Val Asp 
            660                 665                 670         


Leu Asn Lys Asn Gly Gln Val Glu Leu Asn Glu Phe Leu Gln Leu Met 
        675                 680                 685             


Ser Ala Ile Gln Lys Gly Arg Val Ser Gly Ser Arg Leu Ala Ile Leu 
    690                 695                 700                 


Met Lys Thr Ala Glu Glu Asn Leu Asp Arg Arg Val Pro Ile Pro Val 
705                 710                 715                 720 


Asp Arg Ser Cys Gly Gly Leu 
                725         


<210>  6133
<211>  379
<212>  PRT
<213>  Homo Sapiens

<400>  6133

Met Ala Phe Gln Lys Ala Val Lys Gly Thr Ile Leu Val Gly Gly Gly 
1               5                   10                  15      


Ala Leu Ala Thr Val Leu Gly Leu Ser Gln Phe Ala His Tyr Arg Arg 
            20                  25                  30          


Lys Gln Met Asn Leu Ala Tyr Val Lys Ala Ala Asp Cys Ile Ser Glu 
        35                  40                  45              


Pro Val Asn Arg Glu Pro Pro Ser Arg Glu Ala Gln Leu Leu Thr Leu 
    50                  55                  60                  


Gln Asn Thr Ser Glu Phe Asp Ile Leu Val Ile Gly Gly Gly Ala Thr 
65                  70                  75                  80  


Gly Ser Gly Cys Ala Leu Asp Ala Val Thr Arg Gly Leu Lys Thr Ala 
                85                  90                  95      


Leu Val Glu Arg Asp Asp Phe Ser Ser Gly Thr Ser Ser Arg Ser Thr 
            100                 105                 110         


Lys Leu Ile His Gly Gly Val Arg Tyr Leu Gln Lys Ala Ile Met Lys 
        115                 120                 125             


Leu Asp Ile Glu Gln Tyr Arg Met Val Lys Glu Ala Leu His Glu Arg 
    130                 135                 140                 


Ala Asn Leu Leu Glu Ile Ala Pro His Leu Ser Ala Pro Leu Pro Ile 
145                 150                 155                 160 


Met Leu Pro Val Tyr Lys Trp Trp Gln Leu Pro Tyr Tyr Trp Val Gly 
                165                 170                 175     


Ile Lys Leu Tyr Asp Leu Val Ala Gly Ser Asn Cys Leu Lys Ser Ser 
            180                 185                 190         


Tyr Val Leu Ser Lys Ser Arg Ala Leu Glu His Phe Pro Met Leu Gln 
        195                 200                 205             


Lys Asp Lys Leu Val Gly Ala Ile Val Tyr Tyr Asp Gly Gln His Asn 
    210                 215                 220                 


Asp Ala Arg Met Asn Leu Ala Ile Ala Leu Thr Ala Ala Arg Tyr Gly 
225                 230                 235                 240 


Ala Ala Thr Ala Asn Tyr Met Glu Val Val Ser Leu Leu Lys Lys Thr 
                245                 250                 255     


Asp Pro Gln Thr Gly Lys Val Arg Val Ser Gly Ala Arg Cys Lys Asp 
            260                 265                 270         


Val Leu Thr Gly Gln Glu Phe Asp Val Arg Ala Lys Cys Val Ile Asn 
        275                 280                 285             


Ala Thr Gly Pro Phe Thr Asp Ser Val Arg Lys Met Asp Asp Lys Asp 
    290                 295                 300                 


Ala Ala Ala Ile Cys Gln Pro Ser Ala Gly Val His Ile Val Met Pro 
305                 310                 315                 320 


Gly Tyr Tyr Ser Pro Glu Ser Met Gly Leu Leu Asp Pro Ala Thr Ser 
                325                 330                 335     


Asp Gly Arg Val Ile Phe Phe Leu Pro Trp Gln Lys Met Thr Ile Ala 
            340                 345                 350         


Gly Thr Thr Asp Thr Pro Thr Asp Val Thr His His Pro Ile Pro Ser 
        355                 360                 365             


Glu Glu Asp Ile Asn Phe Ile Leu Asn Glu Val 
    370                 375                 


<210>  6134
<211>  56
<212>  PRT
<213>  Homo Sapiens

<400>  6134

Met Ala Phe Gln Lys Ala Val Lys Gly Thr Ile Leu Val Gly Gly Gly 
1               5                   10                  15      


Ala Leu Ala Thr Val Leu Gly Leu Ser Gln Phe Ala His Tyr Arg Arg 
            20                  25                  30          


Lys Gln Asn Ile Val Leu Ser Gly Glu Leu Arg Asn Glu Glu Cys Ile 
        35                  40                  45              


Leu Leu Arg Lys Cys Gly Lys Thr 
    50                  55      


<210>  6135
<211>  56
<212>  PRT
<213>  Homo Sapiens

<400>  6135

Met Ala Phe Gln Lys Ala Val Lys Gly Thr Ile Leu Val Gly Gly Gly 
1               5                   10                  15      


Ala Leu Ala Thr Val Leu Gly Leu Ser Gln Phe Ala His Tyr Arg Arg 
            20                  25                  30          


Lys Gln Asn Ile Val Leu Ser Gly Glu Leu Arg Asn Glu Glu Cys Ile 
        35                  40                  45              


Leu Leu Arg Lys Cys Gly Lys Thr 
    50                  55      


<210>  6136
<211>  601
<212>  PRT
<213>  Homo Sapiens

<400>  6136

Met Lys Leu Asp Ile Glu Gln Tyr Arg Met Val Lys Glu Ala Leu His 
1               5                   10                  15      


Glu Arg Ala Asn Leu Leu Glu Ile Ala Pro His Leu Ser Ala Pro Leu 
            20                  25                  30          


Pro Ile Met Leu Pro Val Tyr Lys Trp Trp Gln Leu Pro Tyr Tyr Trp 
        35                  40                  45              


Val Gly Ile Lys Leu Tyr Asp Leu Val Ala Gly Ser Asn Cys Leu Lys 
    50                  55                  60                  


Ser Ser Tyr Val Leu Ser Lys Ser Arg Ala Leu Glu His Phe Pro Met 
65                  70                  75                  80  


Leu Gln Lys Asp Lys Leu Val Gly Ala Ile Val Tyr Tyr Asp Gly Gln 
                85                  90                  95      


His Asn Asp Ala Arg Met Asn Leu Ala Ile Ala Leu Thr Ala Ala Arg 
            100                 105                 110         


Tyr Gly Ala Ala Thr Ala Asn Tyr Met Glu Val Val Ser Leu Leu Lys 
        115                 120                 125             


Lys Thr Asp Pro Gln Thr Gly Lys Val Arg Val Ser Gly Ala Arg Cys 
    130                 135                 140                 


Lys Asp Val Leu Thr Gly Gln Glu Phe Asp Val Arg Ala Lys Cys Val 
145                 150                 155                 160 


Ile Asn Ala Thr Gly Pro Phe Thr Asp Ser Val Arg Lys Met Asp Asp 
                165                 170                 175     


Lys Asp Ala Ala Ala Ile Cys Gln Pro Ser Ala Gly Val His Ile Val 
            180                 185                 190         


Met Pro Gly Tyr Tyr Ser Pro Glu Ser Met Gly Leu Leu Asp Pro Ala 
        195                 200                 205             


Thr Ser Asp Gly Arg Val Ile Phe Phe Leu Pro Trp Gln Lys Met Thr 
    210                 215                 220                 


Ile Ala Gly Thr Thr Asp Thr Pro Thr Asp Val Thr His His Pro Ile 
225                 230                 235                 240 


Pro Ser Glu Glu Asp Ile Asn Phe Ile Leu Asn Glu Val Arg Asn Tyr 
                245                 250                 255     


Leu Ser Cys Asp Val Glu Val Arg Arg Gly Asp Val Leu Ala Ala Trp 
            260                 265                 270         


Ser Gly Ile Arg Pro Leu Val Thr Asp Pro Lys Ser Ala Asp Thr Gln 
        275                 280                 285             


Ser Ile Ser Arg Asn His Val Val Asp Ile Ser Glu Ser Gly Leu Ile 
    290                 295                 300                 


Thr Ile Ala Gly Gly Lys Trp Thr Thr Tyr Arg Ser Met Ala Glu Asp 
305                 310                 315                 320 


Thr Ile Asn Ala Ala Val Lys Thr His Asn Leu Lys Ala Gly Pro Ser 
                325                 330                 335     


Arg Thr Val Gly Leu Phe Leu Gln Gly Gly Lys Asp Trp Ser Pro Thr 
            340                 345                 350         


Leu Tyr Ile Arg Leu Val Gln Asp Tyr Gly Leu Glu Ser Glu Val Ala 
        355                 360                 365             


Gln His Leu Ala Ala Thr Tyr Gly Asp Lys Ala Phe Glu Val Ala Lys 
    370                 375                 380                 


Met Ala Ser Val Thr Gly Lys Arg Trp Pro Ile Val Gly Val Arg Leu 
385                 390                 395                 400 


Val Ser Glu Phe Pro Tyr Ile Glu Ala Glu Val Lys Tyr Gly Ile Lys 
                405                 410                 415     


Glu Tyr Ala Cys Thr Ala Val Asp Met Ile Ser Arg Arg Thr Arg Leu 
            420                 425                 430         


Ala Phe Leu Asn Val Gln Ala Ala Glu Glu Ala Leu Pro Arg Ile Val 
        435                 440                 445             


Glu Leu Met Gly Arg Glu Leu Asn Trp Asp Asp Tyr Lys Lys Gln Glu 
    450                 455                 460                 


Gln Leu Glu Thr Ala Arg Lys Phe Leu Tyr Tyr Glu Met Gly Tyr Lys 
465                 470                 475                 480 


Ser Arg Ser Glu Gln Leu Thr Asp Arg Ser Glu Ile Ser Leu Leu Pro 
                485                 490                 495     


Ser Asp Ile Asp Arg Tyr Lys Lys Arg Phe His Lys Phe Asp Ala Asp 
            500                 505                 510         


Gln Lys Gly Phe Ile Thr Ile Val Asp Val Gln Arg Val Leu Glu Ser 
        515                 520                 525             


Ile Asn Val Gln Met Asp Glu Asn Thr Leu His Glu Ile Leu Asn Glu 
    530                 535                 540                 


Val Asp Leu Asn Lys Asn Gly Gln Val Glu Leu Asn Glu Phe Leu Gln 
545                 550                 555                 560 


Leu Met Ser Ala Ile Gln Lys Gly Arg Val Ser Gly Ser Arg Leu Ala 
                565                 570                 575     


Ile Leu Met Lys Thr Ala Glu Glu Asn Leu Asp Arg Arg Val Pro Ile 
            580                 585                 590         


Pro Val Asp Arg Ser Cys Gly Gly Leu 
        595                 600     


<210>  6137
<211>  73
<212>  PRT
<213>  Homo Sapiens

<400>  6137

Met Asp Val Thr Ser Gln Ala Arg Gly Val Gly Leu Glu Met Tyr Pro 
1               5                   10                  15      


Gly Thr Ala Gln Pro Ala Ala Pro Asn Thr Thr Ser Pro Glu Leu Asn 
            20                  25                  30          


Leu Ser His Pro Leu Leu Gly Thr Ala Leu Ala Asn Gly Thr Gly Glu 
        35                  40                  45              


Leu Ser Glu His Gln Gln Tyr Val Ile Gly Leu Phe Leu Ser Cys Leu 
    50                  55                  60                  


Tyr Thr Ile Phe Leu Phe Pro Ile Gly 
65                  70              


<210>  6138
<211>  375
<212>  PRT
<213>  Homo Sapiens

<400>  6138

Met Asp Val Thr Ser Gln Ala Arg Gly Val Gly Leu Glu Met Tyr Pro 
1               5                   10                  15      


Gly Thr Ala Gln Pro Ala Ala Pro Asn Thr Thr Ser Pro Glu Leu Asn 
            20                  25                  30          


Leu Ser His Pro Leu Leu Gly Thr Ala Leu Ala Asn Gly Thr Gly Glu 
        35                  40                  45              


Leu Ser Glu His Gln Gln Tyr Val Ile Gly Leu Phe Leu Ser Cys Leu 
    50                  55                  60                  


Tyr Thr Ile Phe Leu Phe Pro Ile Gly Phe Val Gly Asn Ile Leu Ile 
65                  70                  75                  80  


Leu Val Val Asn Ile Ser Phe Arg Glu Lys Met Thr Ile Pro Asp Leu 
                85                  90                  95      


Tyr Phe Ile Asn Leu Ala Val Ala Asp Leu Ile Leu Val Ala Asp Ser 
            100                 105                 110         


Leu Ile Glu Val Phe Asn Leu His Glu Arg Tyr Tyr Asp Ile Ala Val 
        115                 120                 125             


Leu Cys Thr Phe Met Ser Leu Phe Leu Gln Val Asn Met Tyr Ser Ser 
    130                 135                 140                 


Val Phe Phe Leu Thr Trp Met Ser Phe Asp Arg Tyr Ile Ala Leu Ala 
145                 150                 155                 160 


Arg Ala Met Arg Cys Ser Leu Phe Arg Thr Lys His His Ala Arg Leu 
                165                 170                 175     


Ser Cys Gly Leu Ile Trp Met Ala Ser Val Ser Ala Thr Leu Val Pro 
            180                 185                 190         


Phe Thr Ala Val His Leu Gln His Thr Asp Glu Ala Cys Phe Cys Phe 
        195                 200                 205             


Ala Asp Val Arg Glu Val Gln Trp Leu Glu Val Thr Leu Gly Phe Ile 
    210                 215                 220                 


Val Pro Phe Ala Ile Ile Gly Leu Cys Tyr Ser Leu Ile Val Arg Val 
225                 230                 235                 240 


Leu Val Arg Ala His Arg His Arg Gly Leu Arg Pro Arg Arg Gln Lys 
                245                 250                 255     


Ala Leu Arg Met Ile Leu Ala Val Val Leu Val Phe Phe Val Cys Trp 
            260                 265                 270         


Leu Pro Glu Asn Val Phe Ile Ser Val His Leu Leu Gln Arg Thr Gln 
        275                 280                 285             


Pro Gly Ala Ala Pro Cys Lys Gln Ser Phe Arg His Ala His Pro Leu 
    290                 295                 300                 


Thr Gly His Ile Val Asn Leu Ala Ala Phe Ser Asn Ser Cys Leu Asn 
305                 310                 315                 320 


Pro Leu Ile Tyr Ser Phe Leu Gly Glu Thr Phe Arg Asp Lys Leu Arg 
                325                 330                 335     


Leu Tyr Ile Glu Gln Lys Thr Asn Leu Pro Ala Leu Asn Arg Phe Cys 
            340                 345                 350         


His Ala Ala Leu Lys Ala Val Ile Pro Asp Ser Thr Glu Gln Ser Asp 
        355                 360                 365             


Val Arg Phe Ser Ser Ala Val 
    370                 375 


<210>  6139
<211>  375
<212>  PRT
<213>  Homo Sapiens

<400>  6139

Met Asp Val Thr Ser Gln Ala Arg Gly Val Gly Leu Glu Met Tyr Pro 
1               5                   10                  15      


Gly Thr Ala Gln Pro Ala Ala Pro Asn Thr Thr Ser Pro Glu Leu Asn 
            20                  25                  30          


Leu Ser His Pro Leu Leu Gly Thr Ala Leu Ala Asn Gly Thr Gly Glu 
        35                  40                  45              


Leu Ser Glu His Gln Gln Tyr Val Ile Gly Leu Phe Leu Ser Cys Leu 
    50                  55                  60                  


Tyr Thr Ile Phe Leu Phe Pro Ile Gly Phe Val Gly Asn Ile Leu Ile 
65                  70                  75                  80  


Leu Val Val Asn Ile Ser Phe Arg Glu Lys Met Thr Ile Pro Asp Leu 
                85                  90                  95      


Tyr Phe Ile Asn Leu Ala Val Ala Asp Leu Ile Leu Val Ala Asp Ser 
            100                 105                 110         


Leu Ile Glu Val Phe Asn Leu His Glu Arg Tyr Tyr Asp Ile Ala Val 
        115                 120                 125             


Leu Cys Thr Phe Met Ser Leu Phe Leu Gln Val Asn Met Tyr Ser Ser 
    130                 135                 140                 


Val Phe Phe Leu Thr Trp Met Ser Phe Asp Arg Tyr Ile Ala Leu Ala 
145                 150                 155                 160 


Arg Ala Met Arg Cys Ser Leu Phe Arg Thr Lys His His Ala Arg Leu 
                165                 170                 175     


Ser Cys Gly Leu Ile Trp Met Ala Ser Val Ser Ala Thr Leu Val Pro 
            180                 185                 190         


Phe Thr Ala Val His Leu Gln His Thr Asp Glu Ala Cys Phe Cys Phe 
        195                 200                 205             


Ala Asp Val Arg Glu Val Gln Trp Leu Glu Val Thr Leu Gly Phe Ile 
    210                 215                 220                 


Val Pro Phe Ala Ile Ile Gly Leu Cys Tyr Ser Leu Ile Val Arg Val 
225                 230                 235                 240 


Leu Val Arg Ala His Arg His Arg Gly Leu Arg Pro Arg Arg Gln Lys 
                245                 250                 255     


Ala Leu Arg Met Ile Leu Ala Val Val Leu Val Phe Phe Val Cys Trp 
            260                 265                 270         


Leu Pro Glu Asn Val Phe Ile Ser Val His Leu Leu Gln Arg Thr Gln 
        275                 280                 285             


Pro Gly Ala Ala Pro Cys Lys Gln Ser Phe Arg His Ala His Pro Leu 
    290                 295                 300                 


Thr Gly His Ile Val Asn Leu Ala Ala Phe Ser Asn Ser Cys Leu Asn 
305                 310                 315                 320 


Pro Leu Ile Tyr Ser Phe Leu Gly Glu Thr Phe Arg Asp Lys Leu Arg 
                325                 330                 335     


Leu Tyr Ile Glu Gln Lys Thr Asn Leu Pro Ala Leu Asn Arg Phe Cys 
            340                 345                 350         


His Ala Ala Leu Lys Ala Val Ile Pro Asp Ser Thr Glu Gln Ser Asp 
        355                 360                 365             


Val Arg Phe Ser Ser Ala Val 
    370                 375 


<210>  6140
<211>  375
<212>  PRT
<213>  Homo Sapiens

<400>  6140

Met Asp Val Thr Ser Gln Ala Arg Gly Val Gly Leu Glu Met Tyr Pro 
1               5                   10                  15      


Gly Thr Ala Gln Pro Ala Ala Pro Asn Thr Thr Ser Pro Glu Leu Asn 
            20                  25                  30          


Leu Ser His Pro Leu Leu Gly Thr Ala Leu Ala Asn Gly Thr Gly Glu 
        35                  40                  45              


Leu Ser Glu His Gln Gln Tyr Val Ile Gly Leu Phe Leu Ser Cys Leu 
    50                  55                  60                  


Tyr Thr Ile Phe Leu Phe Pro Ile Gly Phe Val Gly Asn Ile Leu Ile 
65                  70                  75                  80  


Leu Val Val Asn Ile Ser Phe Arg Glu Lys Met Thr Ile Pro Asp Leu 
                85                  90                  95      


Tyr Phe Ile Asn Leu Ala Val Ala Asp Leu Ile Leu Val Ala Asp Ser 
            100                 105                 110         


Leu Ile Glu Val Phe Asn Leu His Glu Arg Tyr Tyr Asp Ile Ala Val 
        115                 120                 125             


Leu Cys Thr Phe Met Ser Leu Phe Leu Gln Val Asn Met Tyr Ser Ser 
    130                 135                 140                 


Val Phe Phe Leu Thr Trp Met Ser Phe Asp Arg Tyr Ile Ala Leu Ala 
145                 150                 155                 160 


Arg Ala Met Arg Cys Ser Leu Phe Arg Thr Lys His His Ala Arg Leu 
                165                 170                 175     


Ser Cys Gly Leu Ile Trp Met Ala Ser Val Ser Ala Thr Leu Val Pro 
            180                 185                 190         


Phe Thr Ala Val His Leu Gln His Thr Asp Glu Ala Cys Phe Cys Phe 
        195                 200                 205             


Ala Asp Val Arg Glu Val Gln Trp Leu Glu Val Thr Leu Gly Phe Ile 
    210                 215                 220                 


Val Pro Phe Ala Ile Ile Gly Leu Cys Tyr Ser Leu Ile Val Arg Val 
225                 230                 235                 240 


Leu Val Arg Ala His Arg His Arg Gly Leu Arg Pro Arg Arg Gln Lys 
                245                 250                 255     


Ala Leu Arg Met Ile Leu Ala Val Val Leu Val Phe Phe Val Cys Trp 
            260                 265                 270         


Leu Pro Glu Asn Val Phe Ile Ser Val His Leu Leu Gln Arg Thr Gln 
        275                 280                 285             


Pro Gly Ala Ala Pro Cys Lys Gln Ser Phe Arg His Ala His Pro Leu 
    290                 295                 300                 


Thr Gly His Ile Val Asn Leu Ala Ala Phe Ser Asn Ser Cys Leu Asn 
305                 310                 315                 320 


Pro Leu Ile Tyr Ser Phe Leu Gly Glu Thr Phe Arg Asp Lys Leu Arg 
                325                 330                 335     


Leu Tyr Ile Glu Gln Lys Thr Asn Leu Pro Ala Leu Asn Arg Phe Cys 
            340                 345                 350         


His Ala Ala Leu Lys Ala Val Ile Pro Asp Ser Thr Glu Gln Ser Asp 
        355                 360                 365             


Val Arg Phe Ser Ser Ala Val 
    370                 375 


<210>  6141
<211>  375
<212>  PRT
<213>  Homo Sapiens

<400>  6141

Met Asp Val Thr Ser Gln Ala Arg Gly Val Gly Leu Glu Met Tyr Pro 
1               5                   10                  15      


Gly Thr Ala Gln Pro Ala Ala Pro Asn Thr Thr Ser Pro Glu Leu Asn 
            20                  25                  30          


Leu Ser His Pro Leu Leu Gly Thr Ala Leu Ala Asn Gly Thr Gly Glu 
        35                  40                  45              


Leu Ser Glu His Gln Gln Tyr Val Ile Gly Leu Phe Leu Ser Cys Leu 
    50                  55                  60                  


Tyr Thr Ile Phe Leu Phe Pro Ile Gly Phe Val Gly Asn Ile Leu Ile 
65                  70                  75                  80  


Leu Val Val Asn Ile Ser Phe Arg Glu Lys Met Thr Ile Pro Asp Leu 
                85                  90                  95      


Tyr Phe Ile Asn Leu Ala Val Ala Asp Leu Ile Leu Val Ala Asp Ser 
            100                 105                 110         


Leu Ile Glu Val Phe Asn Leu His Glu Arg Tyr Tyr Asp Ile Ala Val 
        115                 120                 125             


Leu Cys Thr Phe Met Ser Leu Phe Leu Gln Val Asn Met Tyr Ser Ser 
    130                 135                 140                 


Val Phe Phe Leu Thr Trp Met Ser Phe Asp Arg Tyr Ile Ala Leu Ala 
145                 150                 155                 160 


Arg Ala Met Arg Cys Ser Leu Phe Arg Thr Lys His His Ala Arg Leu 
                165                 170                 175     


Ser Cys Gly Leu Ile Trp Met Ala Ser Val Ser Ala Thr Leu Val Pro 
            180                 185                 190         


Phe Thr Ala Val His Leu Gln His Thr Asp Glu Ala Cys Phe Cys Phe 
        195                 200                 205             


Ala Asp Val Arg Glu Val Gln Trp Leu Glu Val Thr Leu Gly Phe Ile 
    210                 215                 220                 


Val Pro Phe Ala Ile Ile Gly Leu Cys Tyr Ser Leu Ile Val Arg Val 
225                 230                 235                 240 


Leu Val Arg Ala His Arg His Arg Gly Leu Arg Pro Arg Arg Gln Lys 
                245                 250                 255     


Ala Leu Arg Met Ile Leu Ala Val Val Leu Val Phe Phe Val Cys Trp 
            260                 265                 270         


Leu Pro Glu Asn Val Phe Ile Ser Val His Leu Leu Gln Arg Thr Gln 
        275                 280                 285             


Pro Gly Ala Ala Pro Cys Lys Gln Ser Phe Arg His Ala His Pro Leu 
    290                 295                 300                 


Thr Gly His Ile Val Asn Leu Ala Ala Phe Ser Asn Ser Cys Leu Asn 
305                 310                 315                 320 


Pro Leu Ile Tyr Ser Phe Leu Gly Glu Thr Phe Arg Asp Lys Leu Arg 
                325                 330                 335     


Leu Tyr Ile Glu Gln Lys Thr Asn Leu Pro Ala Leu Asn Arg Phe Cys 
            340                 345                 350         


His Ala Ala Leu Lys Ala Val Ile Pro Asp Ser Thr Glu Gln Ser Asp 
        355                 360                 365             


Val Arg Phe Ser Ser Ala Val 
    370                 375 


<210>  6142
<211>  408
<212>  PRT
<213>  Homo Sapiens

<400>  6142

Met Asp Val Thr Ser Gln Ala Arg Gly Val Gly Leu Glu Met Tyr Pro 
1               5                   10                  15      


Gly Thr Ala Gln Pro Ala Ala Pro Asn Thr Thr Ser Pro Glu Leu Asn 
            20                  25                  30          


Leu Ser His Pro Leu Leu Gly Thr Ala Leu Ala Asn Gly Thr Gly Glu 
        35                  40                  45              


Leu Ser Glu His Gln Gln Tyr Val Ile Gly Leu Phe Leu Ser Cys Leu 
    50                  55                  60                  


Tyr Thr Ile Phe Leu Phe Pro Ile Gly Phe Val Gly Asn Ile Leu Ile 
65                  70                  75                  80  


Leu Val Val Asn Ile Ser Phe Arg Glu Lys Met Thr Ile Pro Asp Leu 
                85                  90                  95      


Tyr Phe Ile Asn Leu Ala Val Ala Asp Leu Ile Leu Val Ala Asp Ser 
            100                 105                 110         


Leu Ile Glu Val Phe Asn Leu His Glu Arg Tyr Tyr Asp Ile Ala Val 
        115                 120                 125             


Leu Cys Thr Phe Met Ser Leu Phe Leu Gln Val Asn Met Tyr Ser Ser 
    130                 135                 140                 


Val Phe Phe Leu Thr Trp Met Ser Phe Asp Arg Tyr Ile Ala Leu Ala 
145                 150                 155                 160 


Arg Ala Met Arg Cys Ser Leu Phe Arg Thr Lys His His Ala Arg Leu 
                165                 170                 175     


Ser Cys Gly Leu Ile Trp Met Ala Ser Val Ser Ala Thr Leu Val Pro 
            180                 185                 190         


Phe Thr Ala Val His Leu Gln His Thr Asp Glu Ala Cys Phe Cys Phe 
        195                 200                 205             


Ala Asp Val Arg Glu Val Gln Trp Leu Glu Val Thr Leu Gly Phe Ile 
    210                 215                 220                 


Val Pro Phe Ala Ile Ile Gly Leu Cys Tyr Ser Leu Ile Val Arg Val 
225                 230                 235                 240 


Leu Val Arg Ala His Arg His Arg Gly Leu Arg Pro Arg Arg Gln Lys 
                245                 250                 255     


Ala Leu Arg Met Ile Leu Ala Val Val Leu Val Phe Phe Val Cys Trp 
            260                 265                 270         


Leu Pro Glu Asn Val Phe Ile Ser Val His Leu Leu Gln Arg Thr Gln 
        275                 280                 285             


Pro Gly Ala Ala Pro Cys Lys Gln Ser Phe Arg His Ala His Pro Leu 
    290                 295                 300                 


Thr His Gly His Val Met Ser Leu Asn Cys Gly Gln Met Trp Leu Leu 
305                 310                 315                 320 


Ala Pro Arg Gly Leu Ala Arg Val Thr Leu Ala Trp Ser Pro Trp Gly 
                325                 330                 335     


Cys Leu Gly Asn Leu Thr Thr Gly His Leu Ala Leu Leu Thr Gln Asn 
            340                 345                 350         


Cys Tyr Asn Pro Lys Ala Leu Ala Pro Gln Gly Pro Lys Ala Ser Gly 
        355                 360                 365             


Asp Gln Pro Val Thr Gln Leu Leu Pro Ala Asn Pro Ala Cys Arg Cys 
    370                 375                 380                 


Thr Cys Leu Pro Leu Gln Glu Thr Phe Leu Thr Pro Ser Thr Arg Lys 
385                 390                 395                 400 


Ala Thr Arg Arg Gly His Cys Gly 
                405             


<210>  6143
<211>  176
<212>  PRT
<213>  Homo Sapiens

<400>  6143

Met Ser Leu Asn Cys Gly Gln Met Trp Leu Leu Ala Pro Arg Gly Leu 
1               5                   10                  15      


Ala Arg Val Thr Leu Ala Trp Ser Pro Trp Gly Cys Leu Gly Asn Leu 
            20                  25                  30          


Thr Thr Gly His Leu Ala Leu Leu Thr Gln Asn Cys Tyr Asn Pro Lys 
        35                  40                  45              


Ala Leu Ala Pro Gln Gly Pro Lys Ala Ser Gly Asp Gln Pro Val Thr 
    50                  55                  60                  


Gln Leu Leu Pro Ala Asn Pro Ala Cys Arg Cys Thr Cys Leu Pro Leu 
65                  70                  75                  80  


Gln Glu Thr Phe Leu Ser Val Leu His Leu Pro Gly Trp Gln Gln Trp 
                85                  90                  95      


Arg Cys Ala Ala Ser Pro Gly Pro Arg Gly Ala Ala Ala Leu Gly Pro 
            100                 105                 110         


Glu Gln Gln Glu Gly Pro Ser Val Glu Arg Pro Pro Ser Ala Pro Gly 
        115                 120                 125             


Trp Phe Ser His Cys Leu Leu Thr Ser Thr Trp Gln Leu His Ser Cys 
    130                 135                 140                 


Gly Leu Gly Pro Cys Glu Leu Pro Cys Gly Leu Val Gly Cys Gln Asp 
145                 150                 155                 160 


Asn Glu Ile Leu Gln His Leu Trp Leu Thr Asn Leu Phe Leu Gln Lys 
                165                 170                 175     


<210>  6144
<211>  129
<212>  PRT
<213>  Homo Sapiens

<400>  6144

Met Pro Met Ala Ser Pro Gln Thr Leu Val Leu Tyr Leu Leu Val Leu 
1               5                   10                  15      


Ala Val Thr Glu Ala Trp Gly Gln Glu Ala Val Ile Pro Gly Cys His 
            20                  25                  30          


Leu His Pro Phe Asn Val Thr Val Arg Ser Asp Arg Gln Gly Thr Cys 
        35                  40                  45              


Gln Gly Ser His Val Ala Gln Ala Cys Val Gly His Cys Glu Ser Ser 
    50                  55                  60                  


Ala Phe Pro Ser Arg Tyr Ser Val Leu Val Ala Ser Gly Tyr Arg His 
65                  70                  75                  80  


Asn Ile Thr Ser Val Ser Gln Cys Cys Thr Ile Ser Gly Leu Lys Lys 
                85                  90                  95      


Val Lys Val Gln Leu Gln Cys Val Gly Ser Arg Arg Glu Glu Leu Glu 
            100                 105                 110         


Ile Phe Thr Ala Arg Ala Cys Gln Cys Asp Met Cys Arg Leu Ser Arg 
        115                 120                 125             


Tyr 
    


<210>  6145
<211>  129
<212>  PRT
<213>  Homo Sapiens

<400>  6145

Met Pro Met Ala Ser Pro Gln Thr Leu Val Leu Tyr Leu Leu Val Leu 
1               5                   10                  15      


Ala Val Thr Glu Ala Trp Gly Gln Glu Ala Val Ile Pro Gly Cys His 
            20                  25                  30          


Leu His Pro Phe Asn Val Thr Val Arg Ser Asp Arg Gln Gly Thr Cys 
        35                  40                  45              


Gln Gly Ser His Val Ala Gln Ala Cys Val Gly His Cys Glu Ser Ser 
    50                  55                  60                  


Ala Phe Pro Ser Arg Tyr Ser Val Leu Val Ala Ser Gly Tyr Arg His 
65                  70                  75                  80  


Asn Ile Thr Ser Val Ser Gln Cys Cys Thr Ile Ser Gly Leu Lys Lys 
                85                  90                  95      


Val Lys Val Gln Leu Gln Cys Val Gly Ser Arg Arg Glu Glu Leu Glu 
            100                 105                 110         


Ile Phe Thr Ala Arg Ala Cys Gln Cys Asp Met Cys Arg Leu Ser Arg 
        115                 120                 125             


Tyr 
    


<210>  6146
<211>  118
<212>  PRT
<213>  Homo Sapiens

<400>  6146

Met Pro Met Ala Ser Pro Gln Thr Leu Val Leu Tyr Leu Leu Val Leu 
1               5                   10                  15      


Ala Val Thr Glu Ala Trp Gly Gln Glu Ala Val Ile Pro Gly Cys His 
            20                  25                  30          


Leu His Pro Phe Asn Val Thr Val Arg Ser Asp Arg Gln Gly Thr Cys 
        35                  40                  45              


Gln Gly Ser His Val Ala Gln Ala Cys Val Gly His Cys Glu Ser Ser 
    50                  55                  60                  


Ala Phe Pro Ser Arg Tyr Ser Val Leu Val Ala Ser Gly Tyr Arg His 
65                  70                  75                  80  


Asn Ile Thr Ser Val Ser Gln Cys Cys Thr Ile Ser Gly Leu Lys Lys 
                85                  90                  95      


Val Arg Arg Ala Arg Ala Arg Trp Met Asp Ala Gly Val Ala Gly Arg 
            100                 105                 110         


Pro Glu Arg Trp Arg Ser 
        115             


<210>  6147
<211>  130
<212>  PRT
<213>  Homo Sapiens

<400>  6147

Met Lys Leu Ala Phe Leu Phe Leu Gly Pro Met Ala Leu Leu Leu Leu 
1               5                   10                  15      


Ala Gly Tyr Gly Cys Val Leu Gly Ala Ser Ser Gly Asn Leu Arg Thr 
            20                  25                  30          


Phe Val Gly Cys Ala Val Arg Glu Phe Thr Phe Leu Ala Lys Lys Pro 
        35                  40                  45              


Gly Cys Arg Gly Leu Arg Ile Thr Thr Asp Ala Cys Trp Gly Arg Cys 
    50                  55                  60                  


Glu Thr Trp Glu Lys Pro Ile Leu Glu Pro Pro Tyr Ile Glu Ala His 
65                  70                  75                  80  


His Arg Val Cys Thr Tyr Asn Glu Thr Lys Gln Val Thr Val Lys Leu 
                85                  90                  95      


Pro Asn Cys Ala Pro Gly Val Asp Pro Phe Tyr Thr Tyr Pro Val Ala 
            100                 105                 110         


Ile Arg Cys Asp Cys Gly Ala Cys Ser Thr Ala Thr Thr Glu Cys Glu 
        115                 120                 125             


Thr Ile 
    130 


<210>  6148
<211>  130
<212>  PRT
<213>  Homo Sapiens

<400>  6148

Met Lys Leu Ala Phe Leu Phe Leu Gly Pro Met Ala Leu Leu Leu Leu 
1               5                   10                  15      


Ala Gly Tyr Gly Cys Val Leu Gly Ala Ser Ser Gly Asn Leu Arg Thr 
            20                  25                  30          


Phe Val Gly Cys Ala Val Arg Glu Phe Thr Phe Leu Ala Lys Lys Pro 
        35                  40                  45              


Gly Cys Arg Gly Leu Arg Ile Thr Thr Asp Ala Cys Trp Gly Arg Cys 
    50                  55                  60                  


Glu Thr Trp Glu Lys Pro Ile Leu Glu Pro Pro Tyr Ile Glu Ala His 
65                  70                  75                  80  


His Arg Val Cys Thr Tyr Asn Glu Thr Lys Gln Val Thr Val Lys Leu 
                85                  90                  95      


Pro Asn Cys Ala Pro Gly Val Asp Pro Phe Tyr Thr Tyr Pro Val Ala 
            100                 105                 110         


Ile Arg Cys Asp Cys Gly Ala Cys Ser Thr Ala Thr Thr Glu Cys Glu 
        115                 120                 125             


Thr Ile 
    130 


<210>  6149
<211>  184
<212>  PRT
<213>  Homo Sapiens

<400>  6149

Met Lys Ala Leu Gly Ala Val Leu Leu Ala Leu Leu Leu Phe Gly Arg 
1               5                   10                  15      


Pro Gly Arg Gly Gln Thr Gln Gln Glu Glu Glu Glu Glu Asp Glu Asp 
            20                  25                  30          


His Gly Pro Asp Asp Tyr Asp Glu Glu Asp Glu Asp Glu Val Glu Glu 
        35                  40                  45              


Glu Glu Thr Asn Arg Leu Pro Gly Gly Arg Ser Arg Val Leu Leu Arg 
    50                  55                  60                  


Cys Tyr Thr Cys Lys Ser Leu Pro Arg Asp Glu Arg Cys Asn Leu Thr 
65                  70                  75                  80  


Gln Asn Cys Ser His Gly Gln Thr Cys Thr Thr Leu Ile Ala His Gly 
                85                  90                  95      


Asn Thr Glu Ser Gly Leu Leu Thr Thr His Ser Thr Trp Cys Thr Asp 
            100                 105                 110         


Ser Cys Gln Pro Ile Thr Lys Thr Val Glu Gly Thr Gln Val Thr Met 
        115                 120                 125             


Thr Cys Cys Gln Ser Ser Leu Cys Asn Val Pro Pro Trp Gln Ser Ser 
    130                 135                 140                 


Arg Val Gln Asp Pro Thr Gly Lys Gly Ala Gly Gly Pro Arg Gly Ser 
145                 150                 155                 160 


Ser Glu Thr Val Gly Ala Ala Leu Leu Leu Asn Leu Leu Ala Gly Leu 
                165                 170                 175     


Gly Ala Met Gly Ala Arg Arg Pro 
            180                 


<210>  6150
<211>  840
<212>  PRT
<213>  Homo Sapiens

<400>  6150

Met Ser Ala Phe Arg Leu Trp Pro Gly Leu Leu Ile Met Leu Gly Ser 
1               5                   10                  15      


Leu Cys His Arg Gly Ser Pro Cys Gly Leu Ser Thr His Val Glu Ile 
            20                  25                  30          


Gly His Arg Ala Leu Glu Phe Leu Gln Leu His Asn Gly Arg Val Asn 
        35                  40                  45              


Tyr Arg Glu Leu Leu Leu Glu His Gln Asp Ala Tyr Gln Ala Gly Ile 
    50                  55                  60                  


Val Phe Pro Asp Cys Phe Tyr Pro Ser Ile Cys Lys Gly Gly Lys Phe 
65                  70                  75                  80  


His Asp Val Ser Glu Ser Thr His Trp Thr Pro Phe Leu Asn Ala Ser 
                85                  90                  95      


Val His Tyr Ile Arg Glu Asn Tyr Pro Leu Pro Trp Glu Lys Asp Thr 
            100                 105                 110         


Glu Lys Leu Val Ala Phe Leu Phe Gly Ile Thr Ser His Met Ala Ala 
        115                 120                 125             


Asp Val Ser Trp His Ser Leu Gly Leu Glu Gln Gly Phe Leu Arg Thr 
    130                 135                 140                 


Met Gly Ala Ile Asp Phe His Gly Ser Tyr Ser Glu Ala His Ser Ala 
145                 150                 155                 160 


Gly Asp Phe Gly Gly Asp Val Leu Ser Gln Phe Glu Phe Asn Phe Asn 
                165                 170                 175     


Tyr Leu Ala Arg Arg Trp Tyr Val Pro Val Lys Asp Leu Leu Gly Ile 
            180                 185                 190         


Tyr Glu Lys Leu Tyr Gly Arg Lys Val Ile Thr Glu Asn Val Ile Val 
        195                 200                 205             


Asp Cys Ser His Ile Gln Phe Leu Glu Met Tyr Gly Glu Met Leu Ala 
    210                 215                 220                 


Val Ser Lys Leu Tyr Pro Thr Tyr Ser Thr Lys Ser Pro Phe Leu Val 
225                 230                 235                 240 


Glu Gln Phe Gln Glu Tyr Phe Leu Gly Gly Leu Asp Asp Met Ala Phe 
                245                 250                 255     


Trp Ser Thr Asn Ile Tyr His Leu Thr Ser Phe Met Leu Glu Asn Gly 
            260                 265                 270         


Thr Ser Asp Cys Asn Leu Pro Glu Asn Pro Leu Phe Ile Ala Cys Gly 
        275                 280                 285             


Gly Gln Gln Asn His Thr Gln Gly Ser Lys Met Gln Lys Asn Asp Phe 
    290                 295                 300                 


His Arg Asn Leu Thr Thr Ser Leu Thr Glu Ser Val Asp Arg Asn Ile 
305                 310                 315                 320 


Asn Tyr Thr Glu Arg Gly Val Phe Phe Ser Val Asn Ser Trp Thr Pro 
                325                 330                 335     


Asp Ser Met Ser Phe Ile Tyr Lys Ala Leu Glu Arg Asn Ile Arg Thr 
            340                 345                 350         


Met Phe Ile Gly Gly Ser Gln Leu Ser Gln Lys His Val Ser Ser Pro 
        355                 360                 365             


Leu Ala Ser Tyr Phe Leu Ser Phe Pro Tyr Ala Arg Leu Gly Trp Ala 
    370                 375                 380                 


Met Thr Ser Ala Asp Leu Asn Gln Asp Gly His Gly Asp Leu Val Val 
385                 390                 395                 400 


Gly Ala Pro Gly Tyr Ser Arg Pro Gly His Ile His Ile Gly Arg Val 
                405                 410                 415     


Tyr Leu Ile Tyr Gly Asn Asp Leu Gly Leu Pro Pro Val Asp Leu Asp 
            420                 425                 430         


Leu Asp Lys Glu Ala His Arg Ile Leu Glu Gly Phe Gln Pro Ser Gly 
        435                 440                 445             


Arg Phe Gly Ser Ala Leu Ala Val Leu Asp Phe Asn Val Asp Gly Val 
    450                 455                 460                 


Pro Asp Leu Ala Val Gly Ala Pro Ser Val Gly Ser Glu Gln Leu Thr 
465                 470                 475                 480 


Tyr Lys Gly Ala Val Tyr Val Tyr Phe Gly Ser Lys Gln Gly Gly Met 
                485                 490                 495     


Ser Ser Ser Pro Asn Ile Thr Ile Ser Cys Gln Asp Ile Tyr Cys Asn 
            500                 505                 510         


Leu Gly Trp Thr Leu Leu Ala Ala Asp Val Asn Gly Asp Ser Glu Pro 
        515                 520                 525             


Asp Leu Val Ile Gly Ser Pro Phe Ala Pro Gly Gly Gly Lys Gln Lys 
    530                 535                 540                 


Gly Ile Val Ala Ala Phe Tyr Ser Gly Pro Ser Leu Ser Asp Lys Glu 
545                 550                 555                 560 


Lys Leu Asn Val Glu Ala Ala Asn Trp Thr Val Arg Gly Glu Glu Asp 
                565                 570                 575     


Phe Ser Trp Phe Gly Tyr Ser Leu His Gly Val Thr Val Asp Asn Arg 
            580                 585                 590         


Thr Leu Leu Leu Val Gly Ser Pro Thr Trp Lys Asn Ala Ser Arg Leu 
        595                 600                 605             


Gly His Leu Leu His Ile Arg Asp Glu Lys Lys Ser Leu Gly Arg Val 
    610                 615                 620                 


Tyr Gly Tyr Phe Pro Pro Asn Gly Gln Ser Trp Phe Thr Ile Ser Gly 
625                 630                 635                 640 


Asp Lys Ala Met Gly Lys Leu Gly Thr Ser Leu Ser Ser Gly His Val 
                645                 650                 655     


Leu Met Asn Gly Thr Leu Lys Gln Val Leu Leu Val Gly Ala Pro Thr 
            660                 665                 670         


Tyr Asp Asp Val Ser Lys Val Ala Phe Leu Thr Val Thr Leu His Gln 
        675                 680                 685             


Gly Gly Ala Thr Arg Met Tyr Ala Leu Thr Ser Asp Ala Gln Pro Leu 
    690                 695                 700                 


Leu Leu Ser Thr Phe Ser Gly Asp Arg Arg Phe Ser Arg Phe Gly Gly 
705                 710                 715                 720 


Val Leu His Leu Ser Asp Leu Asp Asp Asp Gly Leu Asp Glu Ile Ile 
                725                 730                 735     


Met Ala Ala Pro Leu Arg Ile Ala Asp Val Thr Ser Gly Leu Ile Gly 
            740                 745                 750         


Gly Glu Asp Gly Arg Val Tyr Val Tyr Asn Gly Lys Glu Thr Thr Leu 
        755                 760                 765             


Gly Asp Met Thr Gly Lys Cys Lys Ser Trp Ile Thr Pro Cys Pro Glu 
    770                 775                 780                 


Glu Lys Ala Gln Tyr Val Leu Ile Ser Pro Glu Ala Ser Ser Arg Phe 
785                 790                 795                 800 


Gly Ser Ser Leu Ile Thr Val Arg Ser Lys Ala Lys Asn Gln Val Val 
                805                 810                 815     


Ile Ala Ala Gly Arg Ser Ser Leu Gly Ala Arg Leu Ser Gly Ala Leu 
            820                 825                 830         


His Val Tyr Ser Leu Gly Ser Asp 
        835                 840 


<210>  6151
<211>  560
<212>  PRT
<213>  Homo Sapiens

<400>  6151

Met Glu Cys Leu Tyr Tyr Phe Leu Gly Phe Leu Leu Leu Ala Ala Arg 
1               5                   10                  15      


Leu Pro Leu Asp Ala Ala Lys Arg Phe His Asp Val Leu Gly Asn Glu 
            20                  25                  30          


Arg Pro Ser Ala Tyr Met Arg Glu His Asn Gln Leu Asn Gly Trp Ser 
        35                  40                  45              


Ser Asp Glu Asn Asp Trp Asn Glu Lys Leu Tyr Pro Val Trp Lys Arg 
    50                  55                  60                  


Gly Asp Met Arg Trp Lys Asn Ser Trp Lys Gly Gly Arg Val Gln Ala 
65                  70                  75                  80  


Val Leu Thr Ser Asp Ser Pro Ala Leu Val Gly Ser Asn Ile Thr Phe 
                85                  90                  95      


Ala Val Asn Leu Ile Phe Pro Arg Cys Gln Lys Glu Asp Ala Asn Gly 
            100                 105                 110         


Asn Ile Val Tyr Glu Lys Asn Cys Arg Asn Glu Ala Gly Leu Ser Ala 
        115                 120                 125             


Asp Pro Tyr Val Tyr Asn Trp Thr Ala Trp Ser Glu Asp Ser Asp Gly 
    130                 135                 140                 


Glu Asn Gly Thr Gly Gln Ser His His Asn Val Phe Pro Asp Gly Lys 
145                 150                 155                 160 


Pro Phe Pro His His Pro Gly Trp Arg Arg Trp Asn Phe Ile Tyr Val 
                165                 170                 175     


Phe His Thr Leu Gly Gln Tyr Phe Gln Lys Leu Gly Arg Cys Ser Val 
            180                 185                 190         


Arg Val Ser Val Asn Thr Ala Asn Val Thr Leu Gly Pro Gln Leu Met 
        195                 200                 205             


Glu Val Thr Val Tyr Arg Arg His Gly Arg Ala Tyr Val Pro Ile Ala 
    210                 215                 220                 


Gln Val Lys Asp Val Tyr Val Val Thr Asp Gln Ile Pro Val Phe Val 
225                 230                 235                 240 


Thr Met Phe Gln Lys Asn Asp Arg Asn Ser Ser Asp Glu Thr Phe Leu 
                245                 250                 255     


Lys Asp Leu Pro Ile Met Phe Asp Val Leu Ile His Asp Pro Ser His 
            260                 265                 270         


Phe Leu Asn Tyr Ser Thr Ile Asn Tyr Lys Trp Ser Phe Gly Asp Asn 
        275                 280                 285             


Thr Gly Leu Phe Val Ser Thr Asn His Thr Val Asn His Thr Tyr Val 
    290                 295                 300                 


Leu Asn Gly Thr Phe Ser Leu Asn Leu Thr Val Lys Ala Ala Ala Pro 
305                 310                 315                 320 


Gly Pro Cys Pro Pro Pro Pro Pro Pro Pro Arg Pro Ser Lys Pro Thr 
                325                 330                 335     


Pro Ser Leu Gly Pro Ala Gly Asp Asn Pro Leu Glu Leu Ser Arg Ile 
            340                 345                 350         


Pro Asp Glu Asn Cys Gln Ile Asn Arg Tyr Gly His Phe Gln Ala Thr 
        355                 360                 365             


Ile Thr Ile Val Glu Gly Ile Leu Glu Val Asn Ile Ile Gln Met Thr 
    370                 375                 380                 


Asp Val Leu Met Pro Val Pro Trp Pro Glu Ser Ser Leu Ile Asp Phe 
385                 390                 395                 400 


Val Val Thr Cys Gln Gly Ser Ile Pro Thr Glu Val Cys Thr Ile Ile 
                405                 410                 415     


Ser Asp Pro Thr Cys Glu Ile Thr Gln Asn Thr Val Cys Ser Pro Val 
            420                 425                 430         


Asp Val Asp Glu Met Cys Leu Leu Thr Val Arg Arg Thr Phe Asn Gly 
        435                 440                 445             


Ser Gly Thr Tyr Cys Val Asn Leu Thr Leu Gly Asp Asp Thr Ser Leu 
    450                 455                 460                 


Ala Leu Thr Ser Thr Leu Ile Ser Val Pro Asp Arg Asp Pro Ala Ser 
465                 470                 475                 480 


Pro Leu Arg Met Ala Asn Ser Ala Leu Ile Ser Val Gly Cys Leu Ala 
                485                 490                 495     


Ile Phe Val Thr Val Ile Ser Leu Leu Val Tyr Lys Lys His Lys Glu 
            500                 505                 510         


Tyr Asn Pro Ile Glu Asn Ser Pro Gly Asn Val Val Arg Ser Lys Gly 
        515                 520                 525             


Leu Ser Val Phe Leu Asn Arg Ala Lys Ala Val Phe Phe Pro Gly Asn 
    530                 535                 540                 


Gln Glu Lys Asp Pro Leu Leu Lys Asn Gln Glu Phe Lys Gly Val Ser 
545                 550                 555                 560 


<210>  6152
<211>  572
<212>  PRT
<213>  Homo Sapiens

<400>  6152

Met Glu Cys Leu Tyr Tyr Phe Leu Gly Phe Leu Leu Leu Ala Ala Arg 
1               5                   10                  15      


Leu Pro Leu Asp Ala Ala Lys Arg Phe His Asp Val Leu Gly Asn Glu 
            20                  25                  30          


Arg Pro Ser Ala Tyr Met Arg Glu His Asn Gln Leu Asn Gly Trp Ser 
        35                  40                  45              


Ser Asp Glu Asn Asp Trp Asn Glu Lys Leu Tyr Pro Val Trp Lys Arg 
    50                  55                  60                  


Gly Asp Met Arg Trp Lys Asn Ser Trp Lys Gly Gly Arg Val Gln Ala 
65                  70                  75                  80  


Val Leu Thr Ser Asp Ser Pro Ala Leu Val Gly Ser Asn Ile Thr Phe 
                85                  90                  95      


Ala Val Asn Leu Ile Phe Pro Arg Cys Gln Lys Glu Asp Ala Asn Gly 
            100                 105                 110         


Asn Ile Val Tyr Glu Lys Asn Cys Arg Asn Glu Ala Gly Leu Ser Ala 
        115                 120                 125             


Asp Pro Tyr Val Tyr Asn Trp Thr Ala Trp Ser Glu Asp Ser Asp Gly 
    130                 135                 140                 


Glu Asn Gly Thr Gly Gln Ser His His Asn Val Phe Pro Asp Gly Lys 
145                 150                 155                 160 


Pro Phe Pro His His Pro Gly Trp Arg Arg Trp Asn Phe Ile Tyr Val 
                165                 170                 175     


Phe His Thr Leu Gly Gln Tyr Phe Gln Lys Leu Gly Arg Cys Ser Val 
            180                 185                 190         


Arg Val Ser Val Asn Thr Ala Asn Val Thr Leu Gly Pro Gln Leu Met 
        195                 200                 205             


Glu Val Thr Val Tyr Arg Arg His Gly Arg Ala Tyr Val Pro Ile Ala 
    210                 215                 220                 


Gln Val Lys Asp Val Tyr Val Val Thr Asp Gln Ile Pro Val Phe Val 
225                 230                 235                 240 


Thr Met Phe Gln Lys Asn Asp Arg Asn Ser Ser Asp Glu Thr Phe Leu 
                245                 250                 255     


Lys Asp Leu Pro Ile Met Phe Asp Val Leu Ile His Asp Pro Ser His 
            260                 265                 270         


Phe Leu Asn Tyr Ser Thr Ile Asn Tyr Lys Trp Ser Phe Gly Asp Asn 
        275                 280                 285             


Thr Gly Leu Phe Val Ser Thr Asn His Thr Val Asn His Thr Tyr Val 
    290                 295                 300                 


Leu Asn Gly Thr Phe Ser Leu Asn Leu Thr Val Lys Ala Ala Ala Pro 
305                 310                 315                 320 


Gly Pro Cys Pro Pro Pro Pro Pro Pro Pro Arg Pro Ser Lys Pro Thr 
                325                 330                 335     


Pro Ser Leu Ala Thr Thr Leu Lys Ser Tyr Asp Ser Asn Thr Pro Gly 
            340                 345                 350         


Pro Ala Gly Asp Asn Pro Leu Glu Leu Ser Arg Ile Pro Asp Glu Asn 
        355                 360                 365             


Cys Gln Ile Asn Arg Tyr Gly His Phe Gln Ala Thr Ile Thr Ile Val 
    370                 375                 380                 


Glu Gly Ile Leu Glu Val Asn Ile Ile Gln Met Thr Asp Val Leu Met 
385                 390                 395                 400 


Pro Val Pro Trp Pro Glu Ser Ser Leu Ile Asp Phe Val Val Thr Cys 
                405                 410                 415     


Gln Gly Ser Ile Pro Thr Glu Val Cys Thr Ile Ile Ser Asp Pro Thr 
            420                 425                 430         


Cys Glu Ile Thr Gln Asn Thr Val Cys Ser Pro Val Asp Val Asp Glu 
        435                 440                 445             


Met Cys Leu Leu Thr Val Arg Arg Thr Phe Asn Gly Ser Gly Thr Tyr 
    450                 455                 460                 


Cys Val Asn Leu Thr Leu Gly Asp Asp Thr Ser Leu Ala Leu Thr Ser 
465                 470                 475                 480 


Thr Leu Ile Ser Val Pro Asp Arg Asp Pro Ala Ser Pro Leu Arg Met 
                485                 490                 495     


Ala Asn Ser Ala Leu Ile Ser Val Gly Cys Leu Ala Ile Phe Val Thr 
            500                 505                 510         


Val Ile Ser Leu Leu Val Tyr Lys Lys His Lys Glu Tyr Asn Pro Ile 
        515                 520                 525             


Glu Asn Ser Pro Gly Asn Val Val Arg Ser Lys Gly Leu Ser Val Phe 
    530                 535                 540                 


Leu Asn Arg Ala Lys Ala Val Phe Phe Pro Gly Asn Gln Glu Lys Asp 
545                 550                 555                 560 


Pro Leu Leu Lys Asn Gln Glu Phe Lys Gly Val Ser 
                565                 570         


<210>  6153
<211>  206
<212>  PRT
<213>  Homo Sapiens

<400>  6153

Met Glu Cys Leu Tyr Tyr Phe Leu Gly Phe Leu Leu Leu Ala Ala Arg 
1               5                   10                  15      


Leu Pro Leu Asp Ala Ala Lys Arg Phe His Asp Val Leu Gly Asn Glu 
            20                  25                  30          


Arg Pro Ser Ala Tyr Met Arg Glu His Asn Gln Leu Asn Gly Trp Ser 
        35                  40                  45              


Ser Asp Glu Asn Asp Trp Asn Glu Lys Leu Tyr Pro Val Trp Lys Arg 
    50                  55                  60                  


Gly Asp Met Arg Trp Lys Asn Ser Trp Lys Gly Gly Arg Val Gln Ala 
65                  70                  75                  80  


Val Leu Thr Ser Asp Ser Pro Ala Leu Val Gly Ser Asn Ile Thr Phe 
                85                  90                  95      


Ala Val Asn Leu Ile Phe Pro Arg Cys Gln Lys Glu Asp Ala Asn Gly 
            100                 105                 110         


Asn Ile Val Tyr Glu Lys Asn Cys Arg Asn Glu Ala Gly Leu Ser Ala 
        115                 120                 125             


Asp Pro Tyr Val Tyr Asn Trp Thr Ala Trp Ser Glu Asp Ser Asp Gly 
    130                 135                 140                 


Glu Asn Gly Thr Gly Gln Ser His His Asn Val Phe Pro Asp Gly Lys 
145                 150                 155                 160 


Pro Phe Pro His His Pro Gly Trp Arg Arg Trp Asn Phe Ile Tyr Val 
                165                 170                 175     


Phe His Thr Leu Gly Trp Leu Leu Gln Thr Pro Lys Leu Leu Leu Tyr 
            180                 185                 190         


Leu Ser Leu Lys Phe Gln Pro Ser Leu Phe Leu Leu Tyr Asn 
        195                 200                 205     


<210>  6154
<211>  588
<212>  PRT
<213>  Homo Sapiens

<400>  6154

Met Ala Arg Gly Gly Ala Gly Ala Glu Glu Ala Ser Leu Arg Ser Asn 
1               5                   10                  15      


Ala Leu Ser Trp Leu Ala Cys Gly Leu Leu Ala Leu Leu Ala Asn Ala 
            20                  25                  30          


Trp Ile Ile Leu Ser Ile Ser Ala Lys Gln Gln Lys His Lys Pro Leu 
        35                  40                  45              


Glu Leu Leu Leu Cys Phe Leu Ala Gly Thr His Ile Leu Met Ala Ala 
    50                  55                  60                  


Val Pro Leu Thr Thr Phe Ala Val Val Gln Leu Arg Arg Gln Ala Ser 
65                  70                  75                  80  


Ser Asp Tyr Asp Trp Asn Glu Ser Ile Cys Lys Val Phe Val Ser Thr 
                85                  90                  95      


Tyr Tyr Thr Leu Ala Leu Ala Thr Cys Phe Thr Val Ala Ser Leu Ser 
            100                 105                 110         


Tyr His Arg Met Trp Met Val Arg Trp Pro Val Asn Tyr Arg Leu Ser 
        115                 120                 125             


Asn Ala Lys Lys Gln Ala Leu His Ala Val Met Gly Ile Trp Met Val 
    130                 135                 140                 


Ser Phe Ile Leu Ser Thr Leu Pro Ser Ile Gly Trp His Asn Asn Gly 
145                 150                 155                 160 


Glu Arg Tyr Tyr Ala Arg Gly Cys Gln Phe Ile Val Ser Lys Ile Gly 
                165                 170                 175     


Leu Gly Phe Gly Val Cys Phe Ser Leu Leu Leu Leu Gly Gly Ile Val 
            180                 185                 190         


Met Gly Leu Val Cys Val Ala Ile Thr Phe Tyr Gln Thr Leu Trp Ala 
        195                 200                 205             


Arg Pro Arg Arg Ala Arg Gln Ala Arg Arg Val Gly Gly Gly Gly Gly 
    210                 215                 220                 


Thr Lys Ala Gly Gly Pro Gly Ala Leu Gly Thr Arg Pro Ala Phe Glu 
225                 230                 235                 240 


Val Pro Ala Ile Val Val Glu Asp Ala Arg Gly Lys Arg Arg Ser Ser 
                245                 250                 255     


Leu Asp Gly Ser Glu Ser Ala Lys Thr Ser Leu Gln Val Thr Asn Leu 
            260                 265                 270         


Val Ser Ala Ile Val Phe Leu Tyr Asp Ser Leu Thr Gly Val Pro Ile 
        275                 280                 285             


Leu Val Val Ser Phe Phe Ser Leu Lys Ser Asp Ser Ala Pro Pro Trp 
    290                 295                 300                 


Met Val Leu Ala Val Leu Trp Cys Ser Met Ala Gln Thr Leu Leu Leu 
305                 310                 315                 320 


Pro Ser Phe Ile Trp Ser Cys Glu Arg Tyr Arg Ala Asp Val Arg Thr 
                325                 330                 335     


Val Trp Glu Gln Cys Val Ala Ile Met Ser Glu Glu Asp Gly Asp Asp 
            340                 345                 350         


Asp Gly Gly Cys Asp Asp Tyr Ala Glu Gly Arg Val Cys Lys Val Arg 
        355                 360                 365             


Phe Asp Ala Asn Gly Ala Thr Gly Pro Gly Ser Arg Asp Pro Ala Gln 
    370                 375                 380                 


Val Lys Leu Leu Pro Gly Arg His Met Leu Phe Pro Pro Leu Glu Arg 
385                 390                 395                 400 


Val His Tyr Leu Gln Val Pro Leu Ser Arg Arg Leu Ser His Asp Glu 
                405                 410                 415     


Thr Asn Ile Phe Ser Thr Pro Arg Glu Pro Gly Ser Phe Leu His Lys 
            420                 425                 430         


Trp Ser Ser Ser Asp Asp Ile Arg Val Leu Pro Ala Gln Ser Arg Ala 
        435                 440                 445             


Leu Gly Gly Pro Pro Glu Tyr Leu Gly Gln Arg His Arg Leu Glu Asp 
    450                 455                 460                 


Glu Glu Asp Glu Glu Glu Ala Glu Gly Gly Gly Leu Ala Ser Leu Arg 
465                 470                 475                 480 


Gln Phe Leu Glu Ser Gly Val Leu Gly Ser Gly Gly Gly Pro Pro Arg 
                485                 490                 495     


Gly Pro Gly Phe Phe Arg Glu Glu Ile Thr Thr Phe Ile Asp Glu Thr 
            500                 505                 510         


Pro Leu Pro Ser Pro Thr Ala Ser Pro Gly His Ser Pro Arg Arg Pro 
        515                 520                 525             


Arg Pro Leu Gly Leu Ser Pro Arg Arg Leu Ser Leu Gly Ser Pro Glu 
    530                 535                 540                 


Ser Arg Ala Val Gly Leu Pro Leu Gly Leu Ser Ala Gly Arg Arg Cys 
545                 550                 555                 560 


Ser Leu Thr Gly Gly Glu Glu Ser Ala Arg Ala Trp Gly Gly Ser Trp 
                565                 570                 575     


Gly Pro Gly Asn Pro Ile Phe Pro Gln Leu Thr Leu 
            580                 585             


<210>  6155
<211>  304
<212>  PRT
<213>  Homo Sapiens

<400>  6155

Met Leu Ser Thr Gly Val Val Ser Phe Phe Ser Leu Lys Ser Asp Ser 
1               5                   10                  15      


Ala Pro Pro Trp Met Val Leu Ala Val Leu Trp Cys Ser Met Ala Gln 
            20                  25                  30          


Thr Leu Leu Leu Pro Ser Phe Ile Trp Ser Cys Glu Arg Tyr Arg Ala 
        35                  40                  45              


Asp Val Arg Thr Val Trp Glu Gln Cys Val Ala Ile Met Ser Glu Glu 
    50                  55                  60                  


Asp Gly Asp Asp Asp Gly Gly Cys Asp Asp Tyr Ala Glu Gly Arg Val 
65                  70                  75                  80  


Cys Lys Val Arg Phe Asp Ala Asn Gly Ala Thr Gly Pro Gly Ser Arg 
                85                  90                  95      


Asp Pro Ala Gln Val Lys Leu Leu Pro Gly Arg His Met Leu Phe Pro 
            100                 105                 110         


Pro Leu Glu Arg Val His Tyr Leu Gln Val Pro Leu Ser Arg Arg Leu 
        115                 120                 125             


Ser His Asp Glu Thr Asn Ile Phe Ser Thr Pro Arg Glu Pro Gly Ser 
    130                 135                 140                 


Phe Leu His Lys Trp Ser Ser Ser Asp Asp Ile Arg Val Leu Pro Ala 
145                 150                 155                 160 


Gln Ser Arg Ala Leu Gly Gly Pro Pro Glu Tyr Leu Gly Gln Arg His 
                165                 170                 175     


Arg Leu Glu Asp Glu Glu Asp Glu Glu Glu Ala Glu Gly Gly Gly Leu 
            180                 185                 190         


Ala Ser Leu Arg Gln Phe Leu Glu Ser Gly Val Leu Gly Ser Gly Gly 
        195                 200                 205             


Gly Pro Pro Arg Gly Pro Gly Phe Phe Arg Glu Glu Ile Thr Thr Phe 
    210                 215                 220                 


Ile Asp Glu Thr Pro Leu Pro Ser Pro Thr Ala Ser Pro Gly His Ser 
225                 230                 235                 240 


Pro Arg Arg Pro Arg Pro Leu Gly Leu Ser Pro Arg Arg Leu Ser Leu 
                245                 250                 255     


Gly Ser Pro Glu Ser Arg Ala Val Gly Leu Pro Leu Gly Leu Ser Ala 
            260                 265                 270         


Gly Arg Arg Cys Ser Leu Thr Gly Gly Glu Glu Ser Ala Arg Ala Trp 
        275                 280                 285             


Gly Gly Ser Trp Gly Pro Gly Asn Pro Ile Phe Pro Gln Leu Thr Leu 
    290                 295                 300                 


<210>  6156
<211>  284
<212>  PRT
<213>  Homo Sapiens

<400>  6156

Met Val Leu Ala Val Leu Trp Cys Ser Met Ala Gln Thr Leu Leu Leu 
1               5                   10                  15      


Pro Ser Phe Ile Trp Ser Cys Glu Arg Tyr Arg Ala Asp Val Arg Thr 
            20                  25                  30          


Val Trp Glu Gln Cys Val Ala Ile Met Ser Glu Glu Asp Gly Asp Asp 
        35                  40                  45              


Asp Gly Gly Cys Asp Asp Tyr Ala Glu Gly Arg Val Cys Lys Val Arg 
    50                  55                  60                  


Phe Asp Ala Asn Gly Ala Thr Gly Pro Gly Ser Arg Asp Pro Ala Gln 
65                  70                  75                  80  


Val Lys Leu Leu Pro Gly Arg His Met Leu Phe Pro Pro Leu Glu Arg 
                85                  90                  95      


Val His Tyr Leu Gln Val Pro Leu Ser Arg Arg Leu Ser His Asp Glu 
            100                 105                 110         


Thr Asn Ile Phe Ser Thr Pro Arg Glu Pro Gly Ser Phe Leu His Lys 
        115                 120                 125             


Trp Ser Ser Ser Asp Asp Ile Arg Val Leu Pro Ala Gln Ser Arg Ala 
    130                 135                 140                 


Leu Gly Gly Pro Pro Glu Tyr Leu Gly Gln Arg His Arg Leu Glu Asp 
145                 150                 155                 160 


Glu Glu Asp Glu Glu Glu Ala Glu Gly Gly Gly Leu Ala Ser Leu Arg 
                165                 170                 175     


Gln Phe Leu Glu Ser Gly Val Leu Gly Ser Gly Gly Gly Pro Pro Arg 
            180                 185                 190         


Gly Pro Gly Phe Phe Arg Glu Glu Ile Thr Thr Phe Ile Asp Glu Thr 
        195                 200                 205             


Pro Leu Pro Ser Pro Thr Ala Ser Pro Gly His Ser Pro Arg Arg Pro 
    210                 215                 220                 


Arg Pro Leu Gly Leu Ser Pro Arg Arg Leu Ser Leu Gly Ser Pro Glu 
225                 230                 235                 240 


Ser Arg Ala Val Gly Leu Pro Leu Gly Leu Ser Ala Gly Arg Arg Cys 
                245                 250                 255     


Ser Leu Thr Gly Gly Glu Glu Ser Ala Arg Ala Trp Gly Gly Ser Trp 
            260                 265                 270         


Gly Pro Gly Asn Pro Ile Phe Pro Gln Leu Thr Leu 
        275                 280                 


<210>  6157
<211>  228
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6157

Xaa Ile Thr Phe Tyr Gln Thr Leu Trp Ala Arg Pro Arg Arg Ala Arg 
1               5                   10                  15      


Gln Ala Arg Arg Val Gly Gly Gly Gly Gly Thr Lys Ala Gly Gly Pro 
            20                  25                  30          


Gly Ala Leu Gly Thr Arg Pro Ala Phe Glu Val Pro Ala Ile Val Val 
        35                  40                  45              


Glu Asp Ala Arg Gly Lys Arg Arg Ser Ser Leu Asp Gly Ser Glu Ser 
    50                  55                  60                  


Ala Lys Thr Ser Leu Gln Val Thr Asn Leu Val Val Ser Phe Phe Ser 
65                  70                  75                  80  


Leu Lys Ser Asp Ser Ala Pro Pro Trp Met Val Leu Ala Val Leu Trp 
                85                  90                  95      


Cys Ser Met Ala Gln Thr Leu Leu Leu Pro Ser Phe Ile Trp Ser Cys 
            100                 105                 110         


Glu Arg Tyr Arg Ala Asp Val Arg Thr Val Trp Glu Gln Cys Val Ala 
        115                 120                 125             


Ile Met Ser Glu Glu Asp Gly Asp Asp Asp Gly Gly Cys Asp Asp Tyr 
    130                 135                 140                 


Ala Glu Gly Arg Val Cys Lys Val Arg Phe Asp Ala Asn Gly Ala Thr 
145                 150                 155                 160 


Gly Pro Gly Ser Arg Asp Pro Ala Gln Val Lys Leu Leu Pro Gly Arg 
                165                 170                 175     


His Met Leu Phe Pro Pro Leu Glu Arg Val His Tyr Leu Gln Leu Lys 
            180                 185                 190         


Lys Leu Asp Leu Ala Ala Ala Ala Ala His Thr Phe Phe Val Ala Asn 
        195                 200                 205             


Pro Met His Leu Gln Met Arg Glu Asp Met Ala Lys Tyr Arg Arg Met 
    210                 215                 220                 


Ser Gly Val Arg 
225             


<210>  6158
<211>  138
<212>  PRT
<213>  Homo Sapiens

<400>  6158

Met Ala Arg Leu Leu Gln Ala Ser Cys Leu Leu Ser Leu Leu Leu Ala 
1               5                   10                  15      


Gly Phe Val Ser Gln Ser Arg Gly Gln Glu Lys Ser Lys Ala Pro Arg 
            20                  25                  30          


Gln Met Gly Asn Pro Gln Met Asp Cys His Gly Gly Ile Ser Gly Thr 
        35                  40                  45              


Ile Tyr Glu Tyr Gly Ala Leu Thr Ile Asp Gly Glu Glu Tyr Ile Pro 
    50                  55                  60                  


Phe Lys Gln Tyr Ala Gly Lys Tyr Val Leu Phe Val Asn Val Ala Ser 
65                  70                  75                  80  


Tyr Gly Leu Thr Gly Gln Tyr Ile Glu Leu Asn Ala Leu Gln Glu Glu 
                85                  90                  95      


Leu Ala Pro Phe Gly Leu Val Ile Leu Gly Phe Pro Cys Asn Gln Phe 
            100                 105                 110         


Gly Lys Gln Glu Pro Gly Glu Asn Ser Glu Ile Leu Pro Thr Leu Lys 
        115                 120                 125             


Tyr Val Arg Pro Gly Gly Gly Phe Val Pro 
    130                 135             


<210>  6159
<211>  62
<212>  PRT
<213>  Homo Sapiens

<400>  6159

Met Ala Arg Leu Leu Gln Ala Ser Cys Leu Leu Ser Leu Leu Leu Ala 
1               5                   10                  15      


Gly Phe Val Ser Gln Ser Arg Gly Gln Glu Lys Ser Lys Ala Pro Arg 
            20                  25                  30          


Gln Met Gly Asn Pro Gln Val Arg Glu Thr Ser Thr Pro Phe Ala Ala 
        35                  40                  45              


Pro Ser Ala Ala Gly Thr Pro Pro Pro Thr Val Val Val Ser 
    50                  55                  60          


<210>  6160
<211>  72
<212>  PRT
<213>  Homo Sapiens

<400>  6160

Met Ala Arg Leu Leu Gln Ala Ser Cys Leu Leu Ser Leu Leu Leu Ala 
1               5                   10                  15      


Gly Phe Val Ser Gln Ser Arg Gly Gln Glu Lys Ser Lys Met Asp Cys 
            20                  25                  30          


His Gly Gly Ile Ser Gly Thr Ile Tyr Glu Tyr Gly Ala Leu Thr Ile 
        35                  40                  45              


Asp Gly Glu Glu Tyr Ile Pro Phe Lys Gln Tyr Ala Gly Lys Tyr Val 
    50                  55                  60                  


Leu Phe Val Asn Val Ala Ser Tyr 
65                  70          


<210>  6161
<211>  225
<212>  PRT
<213>  Homo Sapiens

<400>  6161

Met Ala Arg Leu Leu Gln Ala Ser Cys Leu Leu Ser Leu Leu Leu Ala 
1               5                   10                  15      


Gly Phe Val Ser Gln Ser Arg Gly Gln Glu Lys Ser Lys Met Asp Cys 
            20                  25                  30          


His Gly Gly Ile Ser Gly Thr Ile Tyr Glu Tyr Gly Ala Leu Thr Ile 
        35                  40                  45              


Asp Gly Glu Glu Tyr Ile Pro Phe Lys Gln Tyr Ala Gly Lys Tyr Val 
    50                  55                  60                  


Leu Phe Val Asn Val Ala Ser Tyr Gly Leu Thr Gly Gln Tyr Ile Glu 
65                  70                  75                  80  


Leu Asn Ala Leu Gln Glu Glu Leu Ala Pro Phe Gly Leu Val Ile Leu 
                85                  90                  95      


Gly Phe Pro Cys Asn Gln Phe Gly Lys Gln Glu Pro Gly Glu Asn Ser 
            100                 105                 110         


Glu Ile Leu Pro Thr Leu Lys Tyr Val Arg Pro Gly Gly Gly Phe Val 
        115                 120                 125             


Pro Asn Phe Gln Leu Phe Glu Lys Gly Asp Val Asn Gly Glu Lys Glu 
    130                 135                 140                 


Gln Lys Phe Tyr Thr Phe Leu Lys Asn Ser Cys Pro Pro Thr Ser Glu 
145                 150                 155                 160 


Leu Leu Gly Thr Ser Asp Arg Leu Phe Trp Glu Pro Met Lys Val His 
                165                 170                 175     


Asp Ile Arg Trp Asn Phe Glu Lys Phe Leu Val Gly Pro Asp Gly Ile 
            180                 185                 190         


Pro Ile Met Arg Trp His His Arg Thr Thr Val Ser Asn Val Lys Met 
        195                 200                 205             


Asp Ile Leu Ser Tyr Met Arg Arg Gln Ala Ala Leu Gly Val Lys Arg 
    210                 215                 220                 


Lys 
225 


<210>  6162
<211>  225
<212>  PRT
<213>  Homo Sapiens

<400>  6162

Met Ala Arg Leu Leu Gln Ala Ser Cys Leu Leu Ser Leu Leu Leu Ala 
1               5                   10                  15      


Gly Phe Val Ser Gln Ser Arg Gly Gln Glu Lys Ser Lys Met Asp Cys 
            20                  25                  30          


His Gly Gly Ile Ser Gly Thr Ile Tyr Glu Tyr Gly Ala Leu Thr Ile 
        35                  40                  45              


Asp Gly Glu Glu Tyr Ile Pro Phe Lys Gln Tyr Ala Gly Lys Tyr Val 
    50                  55                  60                  


Leu Phe Val Asn Val Ala Ser Tyr Gly Leu Thr Gly Gln Tyr Ile Glu 
65                  70                  75                  80  


Leu Asn Ala Leu Gln Glu Glu Leu Ala Pro Phe Gly Leu Val Ile Leu 
                85                  90                  95      


Gly Phe Pro Cys Asn Gln Phe Gly Lys Gln Glu Pro Gly Glu Asn Ser 
            100                 105                 110         


Glu Ile Leu Pro Thr Leu Lys Tyr Val Arg Pro Gly Gly Gly Phe Val 
        115                 120                 125             


Pro Asn Phe Gln Leu Phe Glu Lys Gly Asp Val Asn Gly Glu Lys Glu 
    130                 135                 140                 


Gln Lys Phe Tyr Thr Phe Leu Lys Asn Ser Cys Pro Pro Thr Ser Glu 
145                 150                 155                 160 


Leu Leu Gly Thr Ser Asp Arg Leu Phe Trp Glu Pro Met Lys Val His 
                165                 170                 175     


Asp Ile Arg Trp Asn Phe Glu Lys Phe Leu Val Gly Pro Asp Gly Ile 
            180                 185                 190         


Pro Ile Met Arg Trp His His Arg Thr Thr Val Ser Asn Val Lys Met 
        195                 200                 205             


Asp Ile Leu Ser Tyr Met Arg Arg Gln Ala Ala Leu Gly Val Lys Arg 
    210                 215                 220                 


Lys 
225 


<210>  6163
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  6163

Met Ala Arg Leu Leu Gln Ala Ser Cys Leu Leu Ser Leu Leu Leu Ala 
1               5                   10                  15      


Gly Phe Val Ser Gln Ser Arg Gly Gln Glu Lys Ser Lys Asn Met His 
            20                  25                  30          


Tyr Arg Lys Ser Leu His His Ser Val Trp Ser Phe Trp Ala Phe Pro 
        35                  40                  45              


Ala Thr Asn Leu Glu Asn Arg Asn Gln Glu Arg Thr Gln Arg Ser Phe 
    50                  55                  60                  


Leu Pro Ser Ser Met Ser Asp Gln Val Glu Ala Leu Ser Leu Ile Ser 
65                  70                  75                  80  


Ser Ser Leu Arg Lys Gly Met Ser Met Glu Arg Lys Ser Arg Asn Ser 
                85                  90                  95      


Thr Leu Ser 
            


<210>  6164
<211>  170
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6164

Xaa Cys His Gly Gly Ile Ser Gly Thr Ile Tyr Glu Tyr Gly Ala Leu 
1               5                   10                  15      


Thr Ile Asp Gly Glu Glu Tyr Ile Pro Phe Lys Gln Tyr Ala Gly Lys 
            20                  25                  30          


Tyr Val Leu Phe Val Asn Val Ala Ser Tyr Gly Leu Thr Gly Gln Tyr 
        35                  40                  45              


Ile Glu Leu Asn Ala Leu Gln Glu Glu Leu Ala Pro Phe Gly Leu Val 
    50                  55                  60                  


Ile Leu Gly Phe Pro Cys Asn Gln Phe Gly Lys Gln Glu Pro Gly Glu 
65                  70                  75                  80  


Asn Ser Glu Ile Leu Pro Thr Leu Lys Thr Pro Val Leu Pro Pro Arg 
                85                  90                  95      


Ser Ser Trp Val His Leu Thr Ala Ser Ser Gly Asn Pro Arg Phe Thr 
            100                 105                 110         


Thr Ser Ala Gly Thr Leu Arg Ser Ser Trp Trp Gly Gln Met Val Tyr 
        115                 120                 125             


Pro Ser Cys Ala Gly Thr Thr Gly Pro Arg Ser Ala Thr Ser Arg Trp 
    130                 135                 140                 


Thr Ser Cys Pro Thr Gly Gly Arg Gln Pro Trp Gly Ser Arg Gly Ser 
145                 150                 155                 160 


Asn Arg Pro Ser His Pro Met Ser Thr Met 
                165                 170 


<210>  6165
<211>  79
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6165

Xaa Phe Gly Lys Gln Glu Pro Gly Glu Asn Ser Glu Ile Leu Pro Thr 
1               5                   10                  15      


Leu Lys Tyr Val Arg Pro Gly Gly Gly Phe Val Pro Asn Phe Gln Leu 
            20                  25                  30          


Phe Glu Lys Gly Asp Val Asn Gly Glu Lys Glu Gln Lys Phe Tyr Thr 
        35                  40                  45              


Phe Leu Lys Gly Gln Ala Ile Pro Gln Glu Gly Leu Gly Arg Lys Arg 
    50                  55                  60                  


Val Arg Gly Pro Gln Ala Arg Leu Thr Leu Leu Leu Ser Leu Leu 
65                  70                  75                  


<210>  6166
<211>  174
<212>  PRT
<213>  Homo Sapiens

<400>  6166

Met Cys Ala Ser Arg Asp Asp Trp Arg Cys Ala Arg Ser Met His Glu 
1               5                   10                  15      


Phe Ser Ala Lys Asp Ile Asp Gly His Met Val Asn Leu Asp Lys Tyr 
            20                  25                  30          


Arg Gly Phe Val Cys Ile Val Thr Asn Val Ala Ser Gln Gly Lys Thr 
        35                  40                  45              


Glu Val Asn Tyr Thr Gln Leu Val Asp Leu His Ala Arg Tyr Ala Glu 
    50                  55                  60                  


Cys Gly Leu Arg Ile Leu Ala Phe Pro Cys Asn Gln Phe Gly Lys Gln 
65                  70                  75                  80  


Glu Pro Gly Ser Asn Glu Glu Ile Lys Glu Phe Ala Ala Gly Tyr Asn 
                85                  90                  95      


Val Lys Phe Asp Met Phe Ser Lys Ile Cys Val Asn Gly Asp Asp Ala 
            100                 105                 110         


His Pro Leu Trp Lys Trp Met Lys Ile Gln Pro Lys Gly Lys Gly Ile 
        115                 120                 125             


Leu Gly Lys Thr Ala Trp Gly Leu Trp Gly Ala Ala Gly Asp Ala His 
    130                 135                 140                 


Val His Val Leu Leu Phe Gln Cys His Gln Val Glu Leu His Gln Val 
145                 150                 155                 160 


Pro His Arg Gln Glu Arg Leu Arg Gly Glu Ala Leu Arg Thr 
                165                 170                 


<210>  6167
<211>  240
<212>  PRT
<213>  Homo Sapiens

<400>  6167

Met Cys Ala Ser Arg Asp Asp Trp Arg Cys Ala Arg Ser Met His Glu 
1               5                   10                  15      


Phe Ser Ala Lys Asp Ile Asp Gly His Met Val Asn Leu Asp Lys Tyr 
            20                  25                  30          


Arg Gly Phe Val Cys Ile Val Thr Asn Val Ala Ser Gln Gly Lys Thr 
        35                  40                  45              


Glu Val Asn Tyr Thr Gln Leu Val Asp Leu His Ala Arg Tyr Ala Glu 
    50                  55                  60                  


Cys Gly Leu Arg Ile Leu Ala Phe Pro Cys Asn Gln Phe Gly Lys Gln 
65                  70                  75                  80  


Glu Pro Gly Ser Asn Glu Glu Ile Lys Glu Phe Ala Ala Gly Tyr Asn 
                85                  90                  95      


Val Lys Phe Asp Met Phe Ser Lys Ile Cys Val Asn Gly Asp Asp Ala 
            100                 105                 110         


His Pro Leu Trp Lys Trp Met Lys Ile Gln Pro Lys Gly Lys Gly Ile 
        115                 120                 125             


Leu Gly Asn Ala Ile Lys Trp Asn Phe Thr Lys Phe Gly His Arg Leu 
    130                 135                 140                 


Ser Thr Val Pro His Arg Gln Glu Arg Leu Arg Gly Glu Ala Leu Arg 
145                 150                 155                 160 


Thr His Gly Gly Ala Pro Gly Asp Arg Glu Gly Pro Ala Pro Leu Phe 
                165                 170                 175     


Leu Ala Pro Gln Val Cys Gly Pro Ala Arg Ala Pro Ala His Ala Leu 
            180                 185                 190         


Gly Ala Phe His Arg His Ser Arg Pro Ala Cys Lys Pro Ala Gly Gly 
        195                 200                 205             


Ala Asp Pro Lys Ile Gln Arg Ala Pro Arg Arg Arg Lys Val Pro Trp 
    210                 215                 220                 


Pro Ala Gly Leu Gly Ser Ala Pro Pro Pro Leu Ala Thr Leu Trp Glu 
225                 230                 235                 240 


<210>  6168
<211>  169
<212>  PRT
<213>  Homo Sapiens

<400>  6168

Met Cys Ala Ser Arg Asp Asp Trp Arg Cys Ala Arg Ser Met His Glu 
1               5                   10                  15      


Phe Ser Ala Lys Asp Ile Asp Gly His Met Val Asn Leu Asp Lys Tyr 
            20                  25                  30          


Arg Gly Phe Val Cys Ile Val Thr Asn Val Ala Ser Gln Gly Lys Thr 
        35                  40                  45              


Glu Val Asn Tyr Thr Gln Leu Val Asp Leu His Ala Arg Tyr Ala Glu 
    50                  55                  60                  


Cys Gly Leu Arg Ile Leu Ala Phe Pro Cys Asn Gln Phe Gly Lys Gln 
65                  70                  75                  80  


Glu Pro Gly Ser Asn Glu Glu Ile Lys Glu Phe Ala Ala Gly Tyr Asn 
                85                  90                  95      


Val Lys Phe Asp Met Phe Ser Lys Ile Cys Val Asn Gly Asp Asp Ala 
            100                 105                 110         


His Pro Leu Trp Lys Trp Met Lys Ile Gln Pro Lys Gly Lys Gly Ile 
        115                 120                 125             


Leu Gly Asn Ala Ile Lys Trp Asn Phe Thr Lys Phe Leu Ile Asp Lys 
    130                 135                 140                 


Asn Gly Cys Val Val Lys Arg Tyr Gly Pro Met Glu Glu Pro Leu Val 
145                 150                 155                 160 


Ile Glu Lys Asp Leu Pro His Tyr Phe 
                165                 


<210>  6169
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  6169

Met Gly Arg Ala Gly Ala Gly Ser Pro Gly Arg Arg Arg Gln Arg Cys 
1               5                   10                  15      


Gln Ser Arg Gly Arg Arg Arg Pro Arg Ala Pro Arg Arg Arg Lys Ala 
            20                  25                  30          


Pro Ala Cys Arg Arg Arg Arg Ala Arg Arg Arg Arg Lys Lys Pro Cys 
        35                  40                  45              


Pro Arg Ser Leu Arg Pro Glu Ile His Glu Cys Pro Lys Ser Gln Asp 
    50                  55                  60                  


Pro Cys Ala Ser Arg Asp Asp Trp Arg Cys Ala Arg Ser Met His Glu 
65                  70                  75                  80  


Phe Ser Ala Lys Asp Ile Asp Gly His Met Val Asn Leu Asp Lys Gly 
                85                  90                  95      


Phe Val Cys Ile Val Thr Asn Val Ala Ser Gln Gly Lys Thr Glu Val 
            100                 105                 110         


Asn Tyr Thr Gln Leu Val Asp Leu His Ala Arg Tyr Ala Glu Cys Gly 
        115                 120                 125             


Leu Arg Ile Leu Ala 
    130             


<210>  6170
<211>  233
<212>  PRT
<213>  Homo Sapiens

<400>  6170

Met Gly Arg Ala Gly Ala Gly Ser Pro Gly Arg Arg Arg Gln Arg Cys 
1               5                   10                  15      


Gln Ser Arg Gly Arg Arg Arg Pro Arg Ala Pro Arg Arg Arg Lys Ala 
            20                  25                  30          


Pro Ala Cys Arg Arg Arg Arg Ala Arg Arg Arg Arg Lys Lys Pro Cys 
        35                  40                  45              


Pro Arg Ser Leu Arg Pro Glu Ile His Glu Cys Pro Lys Ser Gln Asp 
    50                  55                  60                  


Pro Cys Ala Ser Arg Asp Asp Trp Arg Cys Ala Arg Ser Met His Glu 
65                  70                  75                  80  


Phe Ser Ala Lys Asp Ile Asp Gly His Met Val Asn Leu Asp Lys Tyr 
                85                  90                  95      


Arg Gly Phe Val Cys Ile Val Thr Asn Val Ala Ser Gln Gly Lys Thr 
            100                 105                 110         


Glu Val Asn Tyr Thr Gln Leu Val Asp Leu His Ala Arg Tyr Ala Glu 
        115                 120                 125             


Cys Gly Leu Arg Ile Leu Ala Phe Pro Cys Asn Gln Phe Gly Lys Gln 
    130                 135                 140                 


Glu Pro Gly Ser Asn Glu Glu Ile Lys Glu Phe Ala Ala Gly Tyr Asn 
145                 150                 155                 160 


Val Lys Phe Asp Met Phe Ser Lys Ile Cys Val Asn Gly Asp Asp Ala 
                165                 170                 175     


His Pro Leu Trp Lys Trp Met Lys Ile Gln Pro Lys Gly Lys Gly Ile 
            180                 185                 190         


Leu Gly Asn Ala Ile Lys Trp Asn Phe Thr Lys Phe Leu Ile Asp Lys 
        195                 200                 205             


Asn Gly Cys Val Val Lys Arg Tyr Gly Pro Met Glu Glu Pro Leu Val 
    210                 215                 220                 


Ile Glu Lys Asp Leu Pro His Tyr Phe 
225                 230             


<210>  6171
<211>  179
<212>  PRT
<213>  Homo Sapiens

<400>  6171

Met Gly Arg Ala Gly Ala Gly Ser Pro Gly Arg Arg Arg Gln Arg Cys 
1               5                   10                  15      


Gln Ser Arg Gly Arg Arg Arg Pro Arg Ala Pro Arg Arg Arg Lys Ala 
            20                  25                  30          


Pro Ala Cys Arg Arg Arg Arg Ala Arg Arg Arg Arg Lys Lys Pro Cys 
        35                  40                  45              


Pro Arg Ser Leu Arg Pro Glu Ile His Glu Cys Pro Lys Ser Gln Asp 
    50                  55                  60                  


Pro Cys Ala Ser Arg Asp Asp Trp Arg Cys Ala Arg Ser Met His Glu 
65                  70                  75                  80  


Phe Ser Ala Lys Asp Ile Asp Gly His Met Val Asn Leu Asp Lys Tyr 
                85                  90                  95      


Arg Gly Phe Val Cys Ile Val Thr Asn Val Ala Ser Gln Gly Lys Thr 
            100                 105                 110         


Glu Val Asn Tyr Thr Gln Leu Val Asp Leu His Ala Arg Tyr Ala Glu 
        115                 120                 125             


Cys Gly Leu Arg Ile Leu Ala Phe Pro Cys Asn Gln Phe Gly Lys Gln 
    130                 135                 140                 


Glu Pro Gly Ser Asn Glu Glu Ile Lys Glu Phe Ala Ala Gly Tyr Asn 
145                 150                 155                 160 


Val Lys Phe Asp Met Phe Ser Lys Ile Cys Val Asn Gly Asp Asp Ala 
                165                 170                 175     


His Pro Leu 
            


<210>  6172
<211>  154
<212>  PRT
<213>  Homo Sapiens

<400>  6172

Met His Glu Phe Ser Ala Lys Asp Ile Asp Gly His Met Val Asn Leu 
1               5                   10                  15      


Asp Lys Tyr Arg Gly Phe Val Cys Ile Val Thr Asn Val Ala Ser Gln 
            20                  25                  30          


Gly Lys Thr Glu Val Asn Tyr Thr Gln Leu Val Asp Leu His Ala Arg 
        35                  40                  45              


Tyr Ala Glu Cys Gly Leu Arg Ile Leu Ala Phe Pro Cys Asn Gln Phe 
    50                  55                  60                  


Gly Lys Gln Glu Pro Gly Ser Asn Glu Glu Ile Lys Glu Phe Ala Ala 
65                  70                  75                  80  


Gly Tyr Asn Val Lys Phe Asp Met Phe Ser Lys Ile Cys Val Asn Gly 
                85                  90                  95      


Asp Asp Ala His Pro Leu Trp Lys Trp Met Lys Ile Gln Pro Lys Gly 
            100                 105                 110         


Lys Gly Ile Leu Gly Asn Ala Ile Lys Trp Asn Phe Thr Lys Phe Leu 
        115                 120                 125             


Ile Asp Lys Asn Gly Cys Val Val Lys Arg Tyr Gly Pro Met Glu Glu 
    130                 135                 140                 


Pro Leu Val Ile Glu Lys Asp Leu Pro His 
145                 150                 


<210>  6173
<211>  196
<212>  PRT
<213>  Homo Sapiens

<400>  6173

Met Ser Leu Gly Arg Leu Cys Arg Leu Leu Lys Pro Ala Leu Leu Cys 
1               5                   10                  15      


Gly Ala Leu Ala Ala Pro Gly Leu Ala Gly Thr Met Cys Ala Ser Arg 
            20                  25                  30          


Asp Asp Trp Arg Cys Ala Arg Ser Met His Glu Phe Ser Ala Lys Asp 
        35                  40                  45              


Ile Asp Gly His Met Val Asn Leu Asp Lys Tyr Arg Gly Phe Val Cys 
    50                  55                  60                  


Ile Val Thr Asn Val Ala Ser Gln Gly Lys Thr Glu Val Asn Tyr Thr 
65                  70                  75                  80  


Gln Leu Val Asp Leu His Ala Arg Tyr Ala Glu Cys Gly Leu Arg Ile 
                85                  90                  95      


Leu Ala Phe Pro Cys Asn Gln Phe Gly Lys Gln Glu Pro Gly Ser Asn 
            100                 105                 110         


Glu Glu Ile Lys Glu Phe Ala Ala Gly Tyr Asn Val Lys Phe Asp Met 
        115                 120                 125             


Phe Ser Lys Ile Cys Val Asn Gly Asp Asp Ala His Pro Leu Trp Lys 
    130                 135                 140                 


Trp Met Lys Ile Gln Pro Lys Gly Lys Gly Ile Leu Gly Asn Ala Ile 
145                 150                 155                 160 


Lys Trp Asn Phe Thr Lys Phe Leu Ile Asp Lys Asn Gly Cys Val Val 
                165                 170                 175     


Lys Arg Tyr Gly Pro Met Glu Glu Pro Leu Val Ile Glu Lys Asp Leu 
            180                 185                 190         


Pro His Tyr Phe 
        195     


<210>  6174
<211>  196
<212>  PRT
<213>  Homo Sapiens

<400>  6174

Met Ser Leu Gly Arg Leu Cys Arg Leu Leu Lys Pro Ala Leu Leu Cys 
1               5                   10                  15      


Gly Ala Leu Ala Ala Pro Gly Leu Ala Gly Thr Met Cys Ala Ser Arg 
            20                  25                  30          


Asp Asp Trp Arg Cys Ala Arg Ser Met His Glu Phe Ser Ala Lys Asp 
        35                  40                  45              


Ile Asp Gly His Met Val Asn Leu Asp Lys Tyr Arg Gly Phe Val Cys 
    50                  55                  60                  


Ile Val Thr Asn Val Ala Ser Gln Gly Lys Thr Glu Val Asn Tyr Thr 
65                  70                  75                  80  


Gln Leu Val Asp Leu His Ala Arg Tyr Ala Glu Cys Gly Leu Arg Ile 
                85                  90                  95      


Leu Ala Phe Pro Cys Asn Gln Phe Gly Lys Gln Glu Pro Gly Ser Asn 
            100                 105                 110         


Glu Glu Ile Lys Glu Phe Ala Ala Gly Tyr Asn Val Lys Phe Asp Met 
        115                 120                 125             


Phe Ser Lys Ile Cys Val Asn Gly Asp Asp Ala His Pro Leu Trp Lys 
    130                 135                 140                 


Trp Met Lys Ile Gln Pro Lys Gly Lys Gly Ile Leu Gly Asn Ala Ile 
145                 150                 155                 160 


Lys Trp Asn Phe Thr Lys Phe Leu Ile Asp Lys Asn Gly Cys Val Val 
                165                 170                 175     


Lys Arg Tyr Gly Pro Met Glu Glu Pro Leu Val Ile Glu Lys Asp Leu 
            180                 185                 190         


Pro His Tyr Phe 
        195     


<210>  6175
<211>  177
<212>  PRT
<213>  Homo Sapiens

<400>  6175

Met Ser Leu Gly Arg Leu Cys Arg Leu Leu Lys Pro Ala Leu Leu Cys 
1               5                   10                  15      


Gly Ala Leu Ala Ala Pro Gly Leu Ala Gly Thr Met Cys Ala Ser Arg 
            20                  25                  30          


Asp Asp Trp Arg Cys Ala Arg Ser Met His Glu Phe Ser Ala Lys Asp 
        35                  40                  45              


Ile Asp Gly His Met Val Asn Leu Asp Lys Tyr Arg Gly Phe Val Cys 
    50                  55                  60                  


Ile Val Thr Asn Val Ala Ser Gln Gly Lys Thr Glu Val Asn Tyr Thr 
65                  70                  75                  80  


Gln Leu Val Asp Leu His Ala Arg Tyr Ala Glu Cys Gly Leu Arg Ile 
                85                  90                  95      


Leu Ala Phe Pro Cys Asn Gln Phe Gly Lys Gln Glu Pro Gly Ser Asn 
            100                 105                 110         


Glu Glu Ile Lys Glu Phe Ala Ala Gly Tyr Asn Val Lys Phe Asp Met 
        115                 120                 125             


Phe Ser Lys Ile Cys Val Asn Gly Asp Asp Ala His Pro Leu Trp Lys 
    130                 135                 140                 


Trp Met Lys Ile Gln Pro Lys Gly Lys Gly Ile Leu Gly Asn Ser Ser 
145                 150                 155                 160 


Ser Thr Arg Thr Ala Ala Trp Ser Ala Thr Asp Pro Trp Arg Ser Pro 
                165                 170                 175     


Trp 
    


<210>  6176
<211>  166
<212>  PRT
<213>  Homo Sapiens

<400>  6176

Tyr Ala Glu Cys Gly Leu Arg Ile Leu Ala Phe Pro Cys Asn Gln Phe 
1               5                   10                  15      


Gly Lys Gln Glu Pro Gly Ser Asn Glu Glu Ile Lys Glu Phe Ala Ala 
            20                  25                  30          


Gly Tyr Asn Val Lys Phe Asp Met Phe Ser Lys Ile Cys Val Asn Gly 
        35                  40                  45              


Asp Asp Ala His Pro Leu Trp Lys Trp Met Lys Ile Gln Pro Lys Gly 
    50                  55                  60                  


Lys Gly Ile Leu Gly Asn Ala Ile Lys Trp Asn Phe Thr Lys Phe Leu 
65                  70                  75                  80  


Ile Asp Lys Asn Gly Cys Val Val Lys Arg Tyr Gly Pro Met Glu Glu 
                85                  90                  95      


Pro Leu Leu His Lys Cys Val Ala Pro Pro Glu Pro Leu Pro Thr Pro 
            100                 105                 110         


Leu Glu Pro Ser Thr Gly Thr His Asp Gly Leu Pro Ala Asn Leu Leu 
        115                 120                 125             


Val Gly Gln Thr Arg Lys Ser Ser Val His Pro Ala Gly Gly Arg Ser 
    130                 135                 140                 


His Gly Leu Leu Gly Leu Ala Arg Arg Pro His Pro Trp Leu Pro Cys 
145                 150                 155                 160 


Gly Asn Lys Gln Thr Asn 
                165     


<210>  6177
<211>  221
<212>  PRT
<213>  Homo Sapiens

<400>  6177

Met Thr Thr Gln Leu Arg Val Val His Leu Leu Pro Leu Leu Leu Ala 
1               5                   10                  15      


Cys Phe Val Gln Thr Ser Pro Lys Gln Glu Lys Met Lys Met Asp Cys 
            20                  25                  30          


His Lys Asp Glu Lys Gly Thr Ile Tyr Asp Tyr Glu Ala Ile Ala Leu 
        35                  40                  45              


Asn Lys Asn Glu Tyr Val Ser Phe Lys Gln Tyr Val Gly Lys His Ile 
    50                  55                  60                  


Leu Phe Val Asn Val Ala Thr Tyr Cys Gly Leu Thr Ala Gln Tyr Pro 
65                  70                  75                  80  


Glu Leu Asn Ala Leu Gln Glu Glu Leu Lys Pro Tyr Gly Leu Val Val 
                85                  90                  95      


Leu Gly Phe Pro Cys Asn Gln Phe Gly Lys Gln Glu Pro Gly Asp Asn 
            100                 105                 110         


Lys Glu Ile Leu Pro Gly Leu Lys Tyr Val Arg Pro Gly Gly Gly Phe 
        115                 120                 125             


Val Pro Ser Phe Gln Leu Phe Glu Lys Gly Asp Val Asn Gly Glu Lys 
    130                 135                 140                 


Glu Gln Lys Val Phe Ser Phe Leu Lys His Ser Cys Pro His Pro Ser 
145                 150                 155                 160 


Glu Ile Leu Gly Thr Phe Lys Ser Ile Ser Trp Asp Pro Val Lys Val 
                165                 170                 175     


His Asp Ile Arg Trp Asn Phe Glu Lys Phe Leu Val Gly Pro Asp Gly 
            180                 185                 190         


Ile Pro Val Met Arg Trp Ser His Arg Ala Thr Val Ser Ser Val Lys 
        195                 200                 205             


Thr Asp Ile Leu Ala Tyr Leu Lys Gln Phe Lys Thr Lys 
    210                 215                 220     


<210>  6178
<211>  100
<212>  PRT
<213>  Homo Sapiens

<400>  6178

Met Thr Thr Gln Leu Arg Val Val His Leu Leu Pro Leu Leu Leu Ala 
1               5                   10                  15      


Cys Phe Val Gln Thr Ser Pro Lys Gln Glu Lys Met Lys Met Asp Cys 
            20                  25                  30          


His Lys Asp Glu Lys Gly Thr Ile Tyr Asp Tyr Glu Ala Ile Ala Leu 
        35                  40                  45              


Asn Lys Asn Glu Tyr Val Ser Phe Lys Gln Tyr Val Gly Lys His Ile 
    50                  55                  60                  


Leu Phe Val Asn Val Ala Thr Tyr Cys Gly Leu Thr Ala Gln Tyr Pro 
65                  70                  75                  80  


Gly Met Ser Val Gln Gly Glu Asp Leu Tyr Leu Val Ser Ser Phe Leu 
                85                  90                  95      


Arg Lys Gly Met 
            100 


<210>  6179
<211>  220
<212>  PRT
<213>  Homo Sapiens

<400>  6179

Met Phe Gln Gln Phe Gln Ala Ser Cys Leu Val Leu Phe Phe Leu Val 
1               5                   10                  15      


Gly Phe Ala Gln Gln Thr Leu Lys Pro Gln Asn Arg Lys Val Asp Cys 
            20                  25                  30          


Asn Lys Gly Val Thr Gly Thr Ile Tyr Glu Tyr Gly Ala Leu Thr Leu 
        35                  40                  45              


Asn Gly Glu Glu Tyr Ile Gln Phe Lys Gln Phe Ala Gly Lys His Val 
    50                  55                  60                  


Leu Phe Val Asn Val Ala Ala Tyr Gly Leu Ala Ala Gln Tyr Pro Glu 
65                  70                  75                  80  


Leu Asn Ala Leu Gln Glu Glu Leu Lys Asn Phe Gly Val Ile Val Leu 
                85                  90                  95      


Ala Phe Pro Cys Asn Gln Phe Gly Lys Gln Glu Pro Gly Thr Asn Ser 
            100                 105                 110         


Glu Ile Leu Leu Gly Leu Lys Tyr Val Cys Pro Gly Ser Gly Phe Val 
        115                 120                 125             


Pro Ser Phe Gln Leu Phe Glu Lys Gly Asp Val Asn Gly Glu Lys Glu 
    130                 135                 140                 


Gln Lys Val Phe Thr Phe Leu Lys Asn Ser Cys Pro Pro Thr Ser Asp 
145                 150                 155                 160 


Leu Leu Gly Ser Ser Ser Gln Leu Phe Trp Glu Pro Met Lys Val His 
                165                 170                 175     


Asp Ile Arg Trp Asn Phe Glu Lys Phe Leu Val Gly Pro Asp Gly Val 
            180                 185                 190         


Pro Val Met His Trp Phe His Gln Ala Pro Val Ser Thr Val Lys Ser 
        195                 200                 205             


Asp Ile Leu Glu Tyr Leu Lys Gln Phe Asn Thr His 
    210                 215                 220 


<210>  6180
<211>  179
<212>  PRT
<213>  Homo Sapiens

<400>  6180

Met Phe Gln Gln Phe Gln Ala Ser Cys Leu Val Leu Phe Phe Leu Val 
1               5                   10                  15      


Gly Phe Ala Gln Gln Thr Leu Lys Pro Gln Asn Arg Lys Val Asp Cys 
            20                  25                  30          


Asn Lys Gly Val Thr Gly Thr Ile Tyr Glu Tyr Gly Ala Leu Thr Leu 
        35                  40                  45              


Asn Gly Glu Glu Tyr Ile Gln Phe Lys Gln Phe Ala Gly Lys His Val 
    50                  55                  60                  


Leu Phe Val Asn Val Ala Ala Tyr Gly Leu Ala Ala Gln Tyr Pro Glu 
65                  70                  75                  80  


Leu Asn Ala Leu Gln Glu Glu Leu Lys Asn Phe Gly Val Ile Val Leu 
                85                  90                  95      


Ala Phe Pro Cys Asn Gln Phe Gly Lys Gln Glu Pro Gly Thr Asn Ser 
            100                 105                 110         


Glu Ile Leu Leu Gly Leu Lys Thr Pro Ala Leu Arg Pro Leu Ile Phe 
        115                 120                 125             


Trp Ala His Gln Ala Asn Ser Ser Gly Ser Pro Arg Ser Met Ile Ser 
    130                 135                 140                 


Ala Gly Thr Leu Arg Asn Phe Trp Trp Gly Pro Met Glu Ser Leu Ser 
145                 150                 155                 160 


Cys Ile Gly Ser Thr Arg Leu Gln Ser Ala Gln Ser Ser Gln Thr Ser 
                165                 170                 175     


Trp Ser Thr 
            


<210>  6181
<211>  220
<212>  PRT
<213>  Homo Sapiens

<400>  6181

Met Phe Gln Gln Phe Gln Ala Ser Cys Leu Val Leu Phe Phe Leu Val 
1               5                   10                  15      


Gly Phe Ala Gln Gln Thr Leu Lys Pro Gln Asn Arg Lys Val Asp Cys 
            20                  25                  30          


Asn Lys Gly Val Thr Gly Thr Ile Tyr Glu Tyr Gly Ala Leu Thr Leu 
        35                  40                  45              


Asn Gly Glu Glu Tyr Ile Gln Phe Lys Gln Phe Ala Gly Lys His Val 
    50                  55                  60                  


Leu Phe Val Asn Val Ala Ala Tyr Gly Leu Ala Ala Gln Tyr Pro Glu 
65                  70                  75                  80  


Leu Asn Ala Leu Gln Glu Glu Leu Lys Asn Phe Gly Val Ile Val Leu 
                85                  90                  95      


Ala Phe Pro Cys Asn Gln Phe Gly Lys Gln Glu Pro Gly Thr Asn Ser 
            100                 105                 110         


Glu Ile Leu Leu Gly Leu Lys Tyr Val Cys Pro Gly Ser Gly Phe Val 
        115                 120                 125             


Pro Ser Phe Gln Leu Phe Glu Lys Gly Asp Val Asn Gly Glu Lys Glu 
    130                 135                 140                 


Gln Lys Val Phe Thr Phe Leu Lys Asn Ser Cys Pro Pro Thr Ser Asp 
145                 150                 155                 160 


Leu Leu Gly Ser Ser Ser Gln Leu Phe Trp Glu Pro Met Lys Val His 
                165                 170                 175     


Asp Ile Arg Trp Asn Phe Glu Lys Phe Leu Val Gly Pro Asp Gly Val 
            180                 185                 190         


Pro Val Met His Trp Phe His Gln Ala Pro Val Ser Thr Val Lys Ser 
        195                 200                 205             


Asp Ile Leu Glu Tyr Leu Lys Gln Phe Asn Thr His 
    210                 215                 220 


<210>  6182
<211>  187
<212>  PRT
<213>  Homo Sapiens

<400>  6182

Met Val Ala Ala Thr Val Ala Ala Ala Trp Leu Leu Leu Trp Ala Ala 
1               5                   10                  15      


Ala Cys Ala Gln Gln Glu Gln Asp Phe Tyr Asp Phe Lys Ala Val Asn 
            20                  25                  30          


Ile Arg Gly Lys Leu Val Ser Leu Glu Lys Tyr Arg Gly Ser Val Ser 
        35                  40                  45              


Leu Val Val Asn Val Ala Ser Glu Cys Gly Phe Thr Asp Gln His Tyr 
    50                  55                  60                  


Arg Ala Leu Gln Gln Leu Gln Arg Asp Leu Gly Pro His His Phe Asn 
65                  70                  75                  80  


Val Leu Ala Phe Pro Cys Asn Gln Phe Gly Gln Gln Glu Pro Asp Ser 
                85                  90                  95      


Asn Lys Glu Ile Glu Ser Phe Ala Arg Arg Thr Tyr Ser Val Ser Phe 
            100                 105                 110         


Pro Met Phe Ser Lys Ile Ala Val Thr Gly Thr Gly Ala His Pro Ala 
        115                 120                 125             


Phe Lys Tyr Leu Ala Gln Thr Ser Gly Lys Glu Pro Thr Trp Asn Phe 
    130                 135                 140                 


Trp Lys Tyr Leu Val Ala Pro Asp Gly Lys Val Val Gly Ala Trp Asp 
145                 150                 155                 160 


Pro Thr Val Ser Val Glu Glu Val Arg Pro Gln Ile Thr Ala Leu Val 
                165                 170                 175     


Arg Lys Leu Ile Leu Leu Lys Arg Glu Asp Leu 
            180                 185         


<210>  6183
<211>  42
<212>  PRT
<213>  Homo Sapiens

<400>  6183

Met Ser Arg Thr Ala Tyr Thr Val Gly Ala Leu Leu Leu Leu Leu Gly 
1               5                   10                  15      


Thr Leu Leu Pro Ala Ala Glu Gly Lys Lys Lys Gly Ser Gln Gly Ala 
            20                  25                  30          


Ile Pro Pro Pro Ala Lys Arg Pro Cys Met 
        35                  40          


<210>  6184
<211>  143
<212>  PRT
<213>  Homo Sapiens

<400>  6184

Met Ser Arg Thr Ala Tyr Thr Val Gly Ala Leu Leu Leu Leu Leu Gly 
1               5                   10                  15      


Thr Leu Leu Pro Ala Ala Glu Gly Lys Lys Lys Gly Ser Gln Gly Ala 
            20                  25                  30          


Ile Pro Pro Pro Asp Lys Ala Leu His Val Thr Glu Arg Lys Tyr Leu 
        35                  40                  45              


Lys Arg Asp Trp Cys Lys Thr Gln Pro Leu Lys Gln Thr Ile His Glu 
    50                  55                  60                  


Glu Gly Cys Asn Ser Arg Thr Ile Ile Asn Arg Phe Cys Tyr Gly Gln 
65                  70                  75                  80  


Cys Asn Ser Phe Tyr Ile Pro Arg His Ile Arg Lys Glu Glu Gly Ser 
                85                  90                  95      


Phe Gln Ser Cys Ser Phe Cys Lys Pro Lys Lys Phe Thr Thr Met Met 
            100                 105                 110         


Val Thr Leu Asn Cys Pro Glu Leu Gln Pro Pro Thr Lys Lys Lys Arg 
        115                 120                 125             


Val Thr Arg Val Lys Gln Cys Arg Cys Ile Ser Ile Asp Leu Asp 
    130                 135                 140             


<210>  6185
<211>  184
<212>  PRT
<213>  Homo Sapiens

<400>  6185

Met Ser Arg Thr Ala Tyr Thr Val Gly Ala Leu Leu Leu Leu Leu Gly 
1               5                   10                  15      


Thr Leu Leu Pro Ala Ala Glu Gly Lys Lys Lys Gly Ser Gln Gly Ala 
            20                  25                  30          


Ile Pro Pro Pro Asp Lys Ala Gln His Asn Asp Ser Glu Gln Thr Gln 
        35                  40                  45              


Ser Pro Gln Gln Pro Gly Ser Arg Asn Arg Gly Arg Gly Gln Gly Arg 
    50                  55                  60                  


Gly Thr Ala Met Pro Gly Glu Glu Val Leu Glu Ser Ser Gln Glu Ala 
65                  70                  75                  80  


Leu His Val Thr Glu Arg Lys Tyr Leu Lys Arg Asp Trp Cys Lys Thr 
                85                  90                  95      


Gln Pro Leu Lys Gln Thr Ile His Glu Glu Gly Cys Asn Ser Arg Thr 
            100                 105                 110         


Ile Ile Asn Arg Phe Cys Tyr Gly Gln Cys Asn Ser Phe Tyr Ile Pro 
        115                 120                 125             


Arg His Ile Arg Lys Glu Glu Gly Ser Phe Gln Ser Cys Ser Phe Cys 
    130                 135                 140                 


Lys Pro Lys Lys Phe Thr Thr Met Met Val Thr Leu Asn Cys Pro Glu 
145                 150                 155                 160 


Leu Gln Pro Pro Thr Lys Lys Lys Arg Val Thr Arg Val Lys Gln Cys 
                165                 170                 175     


Arg Cys Ile Ser Ile Asp Leu Asp 
            180                 


<210>  6186
<211>  168
<212>  PRT
<213>  Homo Sapiens

<400>  6186

Met Phe Trp Lys Leu Ser Leu Ser Leu Phe Leu Val Ala Val Leu Val 
1               5                   10                  15      


Lys Val Ala Glu Ala Arg Lys Asn Arg Pro Ala Gly Ala Ile Pro Ser 
            20                  25                  30          


Pro Tyr Lys Asp Gly Ser Ser Asn Asn Ser Glu Arg Trp Gln His Gln 
        35                  40                  45              


Ile Lys Glu Val Leu Ala Ser Ser Gln Glu Ala Leu Val Val Thr Glu 
    50                  55                  60                  


Arg Lys Tyr Leu Lys Ser Asp Trp Cys Lys Thr Gln Pro Leu Arg Gln 
65                  70                  75                  80  


Thr Val Ser Glu Glu Gly Cys Arg Ser Arg Thr Ile Leu Asn Arg Phe 
                85                  90                  95      


Cys Tyr Gly Gln Cys Asn Ser Phe Tyr Ile Pro Arg His Val Lys Lys 
            100                 105                 110         


Glu Glu Glu Ser Phe Gln Ser Cys Ala Phe Cys Lys Pro Gln Arg Val 
        115                 120                 125             


Thr Ser Val Leu Val Glu Leu Glu Cys Pro Gly Leu Asp Pro Pro Phe 
    130                 135                 140                 


Arg Leu Lys Lys Ile Gln Lys Val Lys Gln Cys Arg Cys Met Ser Val 
145                 150                 155                 160 


Asn Leu Ser Asp Ser Asp Lys Gln 
                165             


<210>  6187
<211>  81
<212>  PRT
<213>  Homo Sapiens

<400>  6187

Met Met Arg Val Asn Gly Asp Asp Asp Ser Val Ala Ala Leu Ser Phe 
1               5                   10                  15      


Leu Tyr Asp Tyr Tyr Met Gly Pro Lys Glu Lys Arg Ile Leu Ser Ser 
            20                  25                  30          


Ser Thr Gly Gly Arg Asn Asp Gln Gly Lys Arg Tyr Tyr His Gly Met 
        35                  40                  45              


Glu Tyr Glu Thr Asp Leu Thr Pro Leu Glu Ser Pro Thr His Leu Met 
    50                  55                  60                  


Lys Phe Leu Thr Glu Asn Val Ser Gly Thr Pro Glu Tyr Pro Asp Leu 
65                  70                  75                  80  


Leu 
    


<210>  6188
<211>  556
<212>  PRT
<213>  Homo Sapiens

<400>  6188

Met Met Arg Val Asn Gly Asp Asp Asp Ser Val Ala Ala Leu Ser Phe 
1               5                   10                  15      


Leu Tyr Asp Tyr Tyr Met Gly Pro Lys Glu Lys Arg Ile Leu Ser Ser 
            20                  25                  30          


Ser Thr Gly Gly Arg Asn Asp Gln Gly Lys Arg Tyr Tyr His Gly Met 
        35                  40                  45              


Glu Tyr Glu Thr Asp Leu Thr Pro Leu Glu Ser Pro Thr His Leu Met 
    50                  55                  60                  


Lys Phe Leu Thr Glu Asn Val Ser Gly Thr Pro Glu Tyr Pro Asp Leu 
65                  70                  75                  80  


Leu Lys Lys Asn Asn Leu Met Ser Leu Glu Gly Ala Leu Pro Thr Pro 
                85                  90                  95      


Gly Lys Ala Ala Pro Leu Pro Ala Gly Pro Ser Lys Leu Glu Ala Gly 
            100                 105                 110         


Ser Val Asp Ser Tyr Leu Leu Pro Thr Thr Asp Met Tyr Asp Asn Gly 
        115                 120                 125             


Ser Leu Asn Ser Leu Phe Glu Ser Ile His Gly Val Pro Pro Thr Gln 
    130                 135                 140                 


Arg Trp Gln Pro Asp Ser Thr Phe Lys Asp Asp Pro Gln Glu Ser Met 
145                 150                 155                 160 


Leu Phe Pro Asp Ile Leu Lys Thr Ser Pro Glu Pro Pro Cys Pro Glu 
                165                 170                 175     


Asp Tyr Pro Ser Leu Lys Ser Asp Phe Glu Tyr Thr Leu Gly Ser Pro 
            180                 185                 190         


Lys Ala Ile His Ile Lys Ser Gly Glu Ser Pro Met Ala Tyr Leu Asn 
        195                 200                 205             


Lys Gly Gln Phe Tyr Pro Val Thr Leu Arg Thr Pro Ala Gly Gly Lys 
    210                 215                 220                 


Gly Leu Ala Leu Ser Ser Asn Lys Val Lys Ser Val Val Met Val Val 
225                 230                 235                 240 


Phe Asp Asn Glu Lys Val Pro Val Glu Gln Leu Arg Phe Trp Lys His 
                245                 250                 255     


Trp His Ser Arg Gln Pro Thr Ala Lys Gln Arg Val Ile Asp Val Ala 
            260                 265                 270         


Asp Cys Lys Glu Asn Phe Asn Thr Val Glu His Ile Glu Glu Val Ala 
        275                 280                 285             


Tyr Asn Ala Leu Ser Phe Val Trp Asn Val Asn Glu Glu Ala Lys Val 
    290                 295                 300                 


Phe Ile Gly Val Asn Cys Leu Ser Thr Asp Phe Ser Ser Gln Lys Gly 
305                 310                 315                 320 


Val Lys Gly Val Pro Leu Asn Leu Gln Ile Asp Thr Tyr Asp Cys Gly 
                325                 330                 335     


Leu Gly Thr Glu Arg Leu Val His Arg Ala Val Cys Gln Ile Lys Ile 
            340                 345                 350         


Phe Cys Asp Lys Gly Ala Glu Arg Lys Met Arg Asp Asp Glu Arg Lys 
        355                 360                 365             


Gln Phe Arg Arg Lys Val Lys Cys Pro Asp Ser Ser Asn Ser Gly Val 
    370                 375                 380                 


Lys Gly Cys Leu Leu Ser Gly Phe Arg Gly Asn Glu Thr Thr Tyr Leu 
385                 390                 395                 400 


Arg Pro Glu Thr Asp Leu Glu Thr Pro Pro Val Leu Phe Ile Pro Asn 
                405                 410                 415     


Val His Phe Ser Ser Leu Gln Arg Ser Gly Gly Ala Ala Pro Ser Ala 
            420                 425                 430         


Gly Pro Ser Ser Ser Asn Arg Leu Pro Leu Lys Arg Thr Cys Ser Pro 
        435                 440                 445             


Phe Thr Glu Glu Phe Glu Pro Leu Pro Ser Lys Gln Ala Lys Glu Gly 
    450                 455                 460                 


Asp Leu Gln Arg Val Leu Leu Tyr Val Arg Arg Glu Thr Glu Glu Val 
465                 470                 475                 480 


Phe Asp Ala Leu Met Leu Lys Thr Pro Asp Leu Lys Gly Leu Arg Asn 
                485                 490                 495     


Ala Ile Ser Glu Lys Tyr Gly Phe Pro Glu Glu Asn Ile Tyr Lys Val 
            500                 505                 510         


Tyr Lys Lys Cys Lys Arg Gly Ile Leu Val Asn Met Asp Asn Asn Ile 
        515                 520                 525             


Ile Gln His Tyr Ser Asn His Val Ala Phe Leu Leu Asp Met Gly Glu 
    530                 535                 540                 


Leu Asp Gly Lys Ile Gln Ile Ile Leu Lys Glu Leu 
545                 550                 555     


<210>  6189
<211>  626
<212>  PRT
<213>  Homo Sapiens

<400>  6189

Met Ser Asn Glu Leu Asp Phe Arg Ser Val Arg Leu Leu Lys Asn Asp 
1               5                   10                  15      


Pro Val Asn Leu Gln Lys Phe Ser Tyr Thr Ser Glu Asp Glu Ala Trp 
            20                  25                  30          


Lys Thr Tyr Leu Glu Asn Pro Leu Thr Ala Ala Thr Lys Ala Met Met 
        35                  40                  45              


Arg Val Asn Gly Asp Asp Asp Ser Val Ala Ala Leu Ser Phe Leu Tyr 
    50                  55                  60                  


Asp Tyr Tyr Met Gly Pro Lys Glu Lys Arg Ile Leu Ser Ser Ser Thr 
65                  70                  75                  80  


Gly Gly Arg Asn Asp Gln Gly Lys Arg Tyr Tyr His Gly Met Glu Tyr 
                85                  90                  95      


Glu Thr Asp Leu Thr Pro Leu Glu Ser Pro Thr His Leu Met Lys Phe 
            100                 105                 110         


Leu Thr Glu Asn Val Ser Gly Thr Pro Glu Tyr Pro Asp Leu Leu Lys 
        115                 120                 125             


Lys Asn Asn Leu Met Ser Leu Glu Gly Ala Leu Pro Thr Pro Gly Lys 
    130                 135                 140                 


Ala Ala Pro Leu Pro Ala Gly Pro Ser Lys Leu Glu Ala Gly Ser Val 
145                 150                 155                 160 


Asp Ser Tyr Leu Leu Pro Thr Thr Asp Met Tyr Asp Asn Gly Ser Leu 
                165                 170                 175     


Asn Ser Leu Phe Glu Ser Ile His Gly Val Pro Pro Thr Gln Arg Trp 
            180                 185                 190         


Gln Pro Asp Ser Thr Phe Lys Asp Asp Pro Gln Glu Ser Met Leu Phe 
        195                 200                 205             


Pro Asp Ile Leu Lys Thr Ser Pro Glu Pro Pro Cys Pro Glu Asp Tyr 
    210                 215                 220                 


Pro Ser Leu Lys Ser Asp Phe Glu Tyr Thr Leu Gly Ser Pro Lys Ala 
225                 230                 235                 240 


Ile His Ile Lys Ser Gly Glu Ser Pro Met Ala Tyr Leu Asn Lys Gly 
                245                 250                 255     


Gln Phe Tyr Pro Val Thr Leu Arg Thr Pro Ala Gly Gly Lys Gly Leu 
            260                 265                 270         


Ala Leu Ser Ser Asn Lys Val Lys Ser Val Val Met Val Val Phe Asp 
        275                 280                 285             


Asn Glu Lys Val Pro Val Glu Gln Leu Arg Phe Trp Lys His Trp His 
    290                 295                 300                 


Ser Arg Gln Pro Thr Ala Lys Gln Arg Val Ile Asp Val Ala Asp Cys 
305                 310                 315                 320 


Lys Glu Asn Phe Asn Thr Val Glu His Ile Glu Glu Val Ala Tyr Asn 
                325                 330                 335     


Ala Leu Ser Phe Val Trp Asn Val Asn Glu Glu Ala Lys Val Phe Ile 
            340                 345                 350         


Gly Val Asn Cys Leu Ser Thr Asp Phe Ser Ser Gln Lys Gly Val Lys 
        355                 360                 365             


Gly Val Pro Leu Asn Leu Gln Ile Asp Thr Tyr Asp Cys Gly Leu Gly 
    370                 375                 380                 


Thr Glu Arg Leu Val His Arg Ala Val Cys Gln Ile Lys Ile Phe Cys 
385                 390                 395                 400 


Asp Lys Gly Ala Glu Arg Lys Met Arg Asp Asp Glu Arg Lys Gln Phe 
                405                 410                 415     


Arg Arg Lys Val Lys Cys Pro Asp Ser Ser Asn Ser Gly Val Lys Gly 
            420                 425                 430         


Cys Leu Leu Ser Gly Phe Arg Gly Asn Glu Thr Thr Tyr Leu Arg Pro 
        435                 440                 445             


Glu Thr Asp Leu Glu Thr Pro Pro Val Leu Phe Ile Pro Asn Val His 
    450                 455                 460                 


Phe Ser Ser Leu Gln Arg Ser Gly Gly Ala Ala Pro Ser Ala Gly Pro 
465                 470                 475                 480 


Ser Ser Ser Asn Arg Leu Pro Leu Lys Arg Thr Cys Ser Pro Phe Thr 
                485                 490                 495     


Glu Glu Phe Glu Pro Leu Pro Ser Lys Gln Ala Lys Glu Gly Asp Leu 
            500                 505                 510         


Gln Arg Val Leu Leu Tyr Val Arg Arg Glu Thr Glu Glu Val Phe Asp 
        515                 520                 525             


Ala Leu Met Leu Lys Thr Pro Asp Leu Lys Gly Leu Arg Asn Ala Ile 
    530                 535                 540                 


Ser Glu Lys Tyr Gly Phe Pro Glu Glu Asn Ile Tyr Lys Val Tyr Lys 
545                 550                 555                 560 


Lys Cys Lys Arg Gly Glu Thr Ser Leu Leu His Pro Arg Leu Ser Arg 
                565                 570                 575     


His Pro Pro Pro Asp Cys Leu Glu Cys Ser His Pro Val Thr Gln Val 
            580                 585                 590         


Arg Asn Met Gly Phe Gly Asp Gly Phe Trp Arg Gln Arg Asp Leu Asp 
        595                 600                 605             


Ser Asn Pro Ser Pro Thr Thr Val Asn Ser Leu His Phe Thr Val Asn 
    610                 615                 620                 


Ser Glu 
625     


<210>  6190
<211>  602
<212>  PRT
<213>  Homo Sapiens

<400>  6190

Met Ser Asn Glu Leu Asp Phe Arg Ser Val Arg Leu Leu Lys Asn Asp 
1               5                   10                  15      


Pro Val Asn Leu Gln Lys Phe Ser Tyr Thr Ser Glu Asp Glu Ala Trp 
            20                  25                  30          


Lys Thr Tyr Leu Glu Asn Pro Leu Thr Ala Ala Thr Lys Ala Met Met 
        35                  40                  45              


Arg Val Asn Gly Asp Asp Asp Ser Val Ala Ala Leu Ser Phe Leu Tyr 
    50                  55                  60                  


Asp Tyr Tyr Met Gly Pro Lys Glu Lys Arg Ile Leu Ser Ser Ser Thr 
65                  70                  75                  80  


Gly Gly Arg Asn Asp Gln Gly Lys Arg Tyr Tyr His Gly Met Glu Tyr 
                85                  90                  95      


Glu Thr Asp Leu Thr Pro Leu Glu Ser Pro Thr His Leu Met Lys Phe 
            100                 105                 110         


Leu Thr Glu Asn Val Ser Gly Thr Pro Glu Tyr Pro Asp Leu Leu Lys 
        115                 120                 125             


Lys Asn Asn Leu Met Ser Leu Glu Gly Ala Leu Pro Thr Pro Gly Lys 
    130                 135                 140                 


Ala Ala Pro Leu Pro Ala Gly Pro Ser Lys Leu Glu Ala Gly Ser Val 
145                 150                 155                 160 


Asp Ser Tyr Leu Leu Pro Thr Thr Asp Met Tyr Asp Asn Gly Ser Leu 
                165                 170                 175     


Asn Ser Leu Phe Glu Ser Ile His Gly Val Pro Pro Thr Gln Arg Trp 
            180                 185                 190         


Gln Pro Asp Ser Thr Phe Lys Asp Asp Pro Gln Glu Ser Met Leu Phe 
        195                 200                 205             


Pro Asp Ile Leu Lys Thr Ser Pro Glu Pro Pro Cys Pro Glu Asp Tyr 
    210                 215                 220                 


Pro Ser Leu Lys Ser Asp Phe Glu Tyr Thr Leu Gly Ser Pro Lys Ala 
225                 230                 235                 240 


Ile His Ile Lys Ser Gly Glu Ser Pro Met Ala Tyr Leu Asn Lys Gly 
                245                 250                 255     


Gln Phe Tyr Pro Val Thr Leu Arg Thr Pro Ala Gly Gly Lys Gly Leu 
            260                 265                 270         


Ala Leu Ser Ser Asn Lys Val Lys Ser Val Val Met Val Val Phe Asp 
        275                 280                 285             


Asn Glu Lys Val Pro Val Glu Gln Leu Arg Phe Trp Lys His Trp His 
    290                 295                 300                 


Ser Arg Gln Pro Thr Ala Lys Gln Arg Val Ile Asp Val Ala Asp Cys 
305                 310                 315                 320 


Lys Glu Asn Phe Asn Thr Val Glu His Ile Glu Glu Val Ala Tyr Asn 
                325                 330                 335     


Ala Leu Ser Phe Val Trp Asn Val Asn Glu Glu Ala Lys Val Phe Ile 
            340                 345                 350         


Gly Val Asn Cys Leu Ser Thr Asp Phe Ser Ser Gln Lys Gly Val Lys 
        355                 360                 365             


Gly Val Pro Leu Asn Leu Gln Ile Asp Thr Tyr Asp Cys Gly Leu Gly 
    370                 375                 380                 


Thr Glu Arg Leu Val His Arg Ala Val Cys Gln Ile Lys Ile Phe Cys 
385                 390                 395                 400 


Asp Lys Gly Ala Glu Arg Lys Met Arg Asp Asp Glu Arg Lys Gln Phe 
                405                 410                 415     


Arg Arg Lys Val Lys Cys Pro Asp Ser Ser Asn Ser Gly Val Lys Gly 
            420                 425                 430         


Cys Leu Leu Ser Gly Phe Arg Gly Asn Glu Thr Thr Tyr Leu Arg Pro 
        435                 440                 445             


Glu Thr Asp Leu Glu Thr Pro Pro Val Leu Phe Ile Pro Asn Val His 
    450                 455                 460                 


Phe Ser Ser Leu Gln Arg Ser Gly Gly Ala Ala Pro Ser Ala Gly Pro 
465                 470                 475                 480 


Ser Ser Ser Asn Arg Leu Pro Leu Lys Arg Thr Cys Ser Pro Phe Thr 
                485                 490                 495     


Glu Glu Phe Glu Pro Leu Pro Ser Lys Gln Ala Lys Glu Gly Asp Leu 
            500                 505                 510         


Gln Arg Val Leu Leu Tyr Val Arg Arg Glu Thr Glu Glu Val Phe Asp 
        515                 520                 525             


Ala Leu Met Leu Lys Thr Pro Asp Leu Lys Gly Leu Arg Asn Ala Ile 
    530                 535                 540                 


Ser Glu Lys Tyr Gly Phe Pro Glu Glu Asn Ile Tyr Lys Val Tyr Lys 
545                 550                 555                 560 


Lys Cys Lys Arg Gly Ile Leu Val Asn Met Asp Asn Asn Ile Ile Gln 
                565                 570                 575     


His Tyr Ser Asn His Val Ala Phe Leu Leu Asp Met Gly Glu Leu Asp 
            580                 585                 590         


Gly Lys Ile Gln Ile Ile Leu Lys Glu Leu 
        595                 600         


<210>  6191
<211>  607
<212>  PRT
<213>  Homo Sapiens

<400>  6191

Met Trp Met Asn Ser Ile Leu Pro Ile Phe Leu Phe Arg Ser Val Arg 
1               5                   10                  15      


Leu Leu Lys Asn Asp Pro Val Asn Leu Gln Lys Phe Ser Tyr Thr Ser 
            20                  25                  30          


Glu Asp Glu Ala Trp Lys Thr Tyr Leu Glu Asn Pro Leu Thr Ala Ala 
        35                  40                  45              


Thr Lys Ala Met Met Arg Val Asn Gly Asp Asp Asp Ser Val Ala Ala 
    50                  55                  60                  


Leu Ser Phe Leu Tyr Asp Tyr Tyr Met Gly Pro Lys Glu Lys Arg Ile 
65                  70                  75                  80  


Leu Ser Ser Ser Thr Gly Gly Arg Asn Asp Gln Gly Lys Arg Tyr Tyr 
                85                  90                  95      


His Gly Met Glu Tyr Glu Thr Asp Leu Thr Pro Leu Glu Ser Pro Thr 
            100                 105                 110         


His Leu Met Lys Phe Leu Thr Glu Asn Val Ser Gly Thr Pro Glu Tyr 
        115                 120                 125             


Pro Asp Leu Leu Lys Lys Asn Asn Leu Met Ser Leu Glu Gly Ala Leu 
    130                 135                 140                 


Pro Thr Pro Gly Lys Ala Ala Pro Leu Pro Ala Gly Pro Ser Lys Leu 
145                 150                 155                 160 


Glu Ala Gly Ser Val Asp Ser Tyr Leu Leu Pro Thr Thr Asp Met Tyr 
                165                 170                 175     


Asp Asn Gly Ser Leu Asn Ser Leu Phe Glu Ser Ile His Gly Val Pro 
            180                 185                 190         


Pro Thr Gln Arg Trp Gln Pro Asp Ser Thr Phe Lys Asp Asp Pro Gln 
        195                 200                 205             


Glu Ser Met Leu Phe Pro Asp Ile Leu Lys Thr Ser Pro Glu Pro Pro 
    210                 215                 220                 


Cys Pro Glu Asp Tyr Pro Ser Leu Lys Ser Asp Phe Glu Tyr Thr Leu 
225                 230                 235                 240 


Gly Ser Pro Lys Ala Ile His Ile Lys Ser Gly Glu Ser Pro Met Ala 
                245                 250                 255     


Tyr Leu Asn Lys Gly Gln Phe Tyr Pro Val Thr Leu Arg Thr Pro Ala 
            260                 265                 270         


Gly Gly Lys Gly Leu Ala Leu Ser Ser Asn Lys Val Lys Ser Val Val 
        275                 280                 285             


Met Val Val Phe Asp Asn Glu Lys Val Pro Val Glu Gln Leu Arg Phe 
    290                 295                 300                 


Trp Lys His Trp His Ser Arg Gln Pro Thr Ala Lys Gln Arg Val Ile 
305                 310                 315                 320 


Asp Val Ala Asp Cys Lys Glu Asn Phe Asn Thr Val Glu His Ile Glu 
                325                 330                 335     


Glu Val Ala Tyr Asn Ala Leu Ser Phe Val Trp Asn Val Asn Glu Glu 
            340                 345                 350         


Ala Lys Val Phe Ile Gly Val Asn Cys Leu Ser Thr Asp Phe Ser Ser 
        355                 360                 365             


Gln Lys Gly Val Lys Gly Val Pro Leu Asn Leu Gln Ile Asp Thr Tyr 
    370                 375                 380                 


Asp Cys Gly Leu Gly Thr Glu Arg Leu Val His Arg Ala Val Cys Gln 
385                 390                 395                 400 


Ile Lys Ile Phe Cys Asp Lys Gly Ala Glu Arg Lys Met Arg Asp Asp 
                405                 410                 415     


Glu Arg Lys Gln Phe Arg Arg Lys Val Lys Cys Pro Asp Ser Ser Asn 
            420                 425                 430         


Ser Gly Val Lys Gly Cys Leu Leu Ser Gly Phe Arg Gly Asn Glu Thr 
        435                 440                 445             


Thr Tyr Leu Arg Pro Glu Thr Asp Leu Glu Thr Pro Pro Val Leu Phe 
    450                 455                 460                 


Ile Pro Asn Val His Phe Ser Ser Leu Gln Arg Ser Gly Gly Ala Ala 
465                 470                 475                 480 


Pro Ser Ala Gly Pro Ser Ser Ser Asn Arg Leu Pro Leu Lys Arg Thr 
                485                 490                 495     


Cys Ser Pro Phe Thr Glu Glu Phe Glu Pro Leu Pro Ser Lys Gln Ala 
            500                 505                 510         


Lys Glu Gly Asp Leu Gln Arg Val Leu Leu Tyr Val Arg Arg Glu Thr 
        515                 520                 525             


Glu Glu Val Phe Asp Ala Leu Met Leu Lys Thr Pro Asp Leu Lys Gly 
    530                 535                 540                 


Leu Arg Asn Ala Ile Ser Glu Lys Tyr Gly Phe Pro Glu Glu Asn Ile 
545                 550                 555                 560 


Tyr Lys Val Tyr Lys Lys Cys Lys Arg Gly Ile Leu Val Asn Met Asp 
                565                 570                 575     


Asn Asn Ile Ile Gln His Tyr Ser Asn His Val Ala Phe Leu Leu Asp 
            580                 585                 590         


Met Gly Glu Leu Asp Gly Lys Ile Gln Ile Ile Leu Lys Glu Leu 
        595                 600                 605         


<210>  6192
<211>  52
<212>  PRT
<213>  Homo Sapiens

<400>  6192

Met Trp Met Asn Ser Ile Leu Pro Ile Phe Leu Val Pro Arg Arg Ser 
1               5                   10                  15      


Gly Tyr Cys Pro Pro Ala Leu Gly Ala Gly Met Thr Lys Glu Arg Gly 
            20                  25                  30          


Thr Thr Met Ala Trp Asn Met Arg Arg Thr Ser Leu Pro Leu Lys Ala 
        35                  40                  45              


Pro His Thr Ser 
    50          


<210>  6193
<211>  48
<212>  PRT
<213>  Homo Sapiens

<400>  6193

Met Gln Lys Ile Met His Ile Ser Val Leu Leu Ser Pro Val Leu Trp 
1               5                   10                  15      


Gly Leu Ile Phe Gly Val Ser Ser Asn Ser Ile Gln Ile Gly Gly Leu 
            20                  25                  30          


Phe Pro Arg Gly Ala Asp Gln Glu Tyr Ser Ala Phe Arg Val Gly Met 
        35                  40                  45              


<210>  6194
<211>  125
<212>  PRT
<213>  Homo Sapiens

<400>  6194

Met Gln Lys Ile Met His Ile Ser Val Leu Leu Ser Pro Val Leu Trp 
1               5                   10                  15      


Gly Leu Ile Phe Gly Val Ser Ser Asn Ser Ile Gln Ile Gly Gly Leu 
            20                  25                  30          


Phe Pro Arg Gly Ala Asp Gln Glu Tyr Ser Ala Phe Arg Val Gly Met 
        35                  40                  45              


Val Gln Phe Ser Thr Ser Glu Phe Arg Leu Thr Pro His Ile Asp Asn 
    50                  55                  60                  


Leu Glu Val Ala Asn Ser Phe Ala Val Thr Asn Ala Phe Cys Ser Gln 
65                  70                  75                  80  


Phe Ser Arg Gly Val Tyr Ala Ile Phe Gly Phe Tyr Asp Lys Lys Ser 
                85                  90                  95      


Val Asn Thr Ile Thr Ser Phe Cys Gly Thr Leu His Val Ser Phe Ile 
            100                 105                 110         


Thr Pro Ser Phe Pro Thr Asp Gly Thr His Pro Phe Val 
        115                 120                 125 


<210>  6195
<211>  883
<212>  PRT
<213>  Homo Sapiens

<400>  6195

Met Gln Lys Ile Met His Ile Ser Val Leu Leu Ser Pro Val Leu Trp 
1               5                   10                  15      


Gly Leu Ile Phe Gly Val Ser Ser Asn Ser Ile Gln Ile Gly Gly Leu 
            20                  25                  30          


Phe Pro Arg Gly Ala Asp Gln Glu Tyr Ser Ala Phe Arg Val Gly Met 
        35                  40                  45              


Val Gln Phe Ser Thr Ser Glu Phe Arg Leu Thr Pro His Ile Asp Asn 
    50                  55                  60                  


Leu Glu Val Ala Asn Ser Phe Ala Val Thr Asn Ala Phe Cys Ser Gln 
65                  70                  75                  80  


Phe Ser Arg Gly Val Tyr Ala Ile Phe Gly Phe Tyr Asp Lys Lys Ser 
                85                  90                  95      


Val Asn Thr Ile Thr Ser Phe Cys Gly Thr Leu His Val Ser Phe Ile 
            100                 105                 110         


Thr Pro Ser Phe Pro Thr Asp Gly Thr His Pro Phe Val Ile Gln Met 
        115                 120                 125             


Arg Pro Asp Leu Lys Gly Ala Leu Leu Ser Leu Ile Glu Tyr Tyr Gln 
    130                 135                 140                 


Trp Asp Lys Phe Ala Tyr Leu Tyr Asp Ser Asp Arg Gly Leu Ser Thr 
145                 150                 155                 160 


Leu Gln Ala Val Leu Asp Ser Ala Ala Glu Lys Lys Trp Gln Val Thr 
                165                 170                 175     


Ala Ile Asn Val Gly Asn Ile Asn Asn Asp Lys Lys Asp Glu Met Tyr 
            180                 185                 190         


Arg Ser Leu Phe Gln Asp Leu Glu Leu Lys Lys Glu Arg Arg Val Ile 
        195                 200                 205             


Leu Asp Cys Glu Arg Asp Lys Val Asn Asp Ile Val Asp Gln Val Ile 
    210                 215                 220                 


Thr Ile Gly Lys His Val Lys Gly Tyr His Tyr Ile Ile Ala Asn Leu 
225                 230                 235                 240 


Gly Phe Thr Asp Gly Asp Leu Leu Lys Ile Gln Phe Gly Gly Ala Asn 
                245                 250                 255     


Val Ser Gly Phe Gln Ile Val Asp Tyr Asp Asp Ser Leu Val Ser Lys 
            260                 265                 270         


Phe Ile Glu Arg Trp Ser Thr Leu Glu Glu Lys Glu Tyr Pro Gly Ala 
        275                 280                 285             


His Thr Thr Thr Ile Lys Tyr Thr Ser Ala Leu Thr Tyr Asp Ala Val 
    290                 295                 300                 


Gln Val Met Thr Glu Ala Phe Arg Asn Leu Arg Lys Gln Arg Ile Glu 
305                 310                 315                 320 


Ile Ser Arg Arg Gly Asn Ala Gly Asp Cys Leu Ala Asn Pro Ala Val 
                325                 330                 335     


Pro Trp Gly Gln Gly Val Glu Ile Glu Arg Ala Leu Lys Gln Val Gln 
            340                 345                 350         


Val Glu Gly Leu Ser Gly Asn Ile Lys Phe Asp Gln Asn Gly Lys Arg 
        355                 360                 365             


Ile Asn Tyr Thr Ile Asn Ile Met Glu Leu Lys Thr Asn Gly Pro Arg 
    370                 375                 380                 


Lys Ile Gly Tyr Trp Ser Glu Val Asp Lys Met Val Val Thr Leu Thr 
385                 390                 395                 400 


Glu Leu Pro Ser Gly Asn Asp Thr Ser Gly Leu Glu Asn Lys Thr Val 
                405                 410                 415     


Val Val Thr Thr Ile Leu Glu Ser Pro Tyr Val Met Met Lys Lys Asn 
            420                 425                 430         


His Glu Met Leu Glu Gly Asn Glu Arg Tyr Glu Gly Tyr Cys Val Asp 
        435                 440                 445             


Leu Ala Ala Glu Ile Ala Lys His Cys Gly Phe Lys Tyr Lys Leu Thr 
    450                 455                 460                 


Ile Val Gly Asp Gly Lys Tyr Gly Ala Arg Asp Ala Asp Thr Lys Ile 
465                 470                 475                 480 


Trp Asn Gly Met Val Gly Glu Leu Val Tyr Gly Lys Ala Asp Ile Ala 
                485                 490                 495     


Ile Ala Pro Leu Thr Ile Thr Leu Val Arg Glu Glu Val Ile Asp Phe 
            500                 505                 510         


Ser Lys Pro Phe Met Ser Leu Gly Ile Ser Ile Met Ile Lys Lys Pro 
        515                 520                 525             


Gln Lys Ser Lys Pro Gly Val Phe Ser Phe Leu Asp Pro Leu Ala Tyr 
    530                 535                 540                 


Glu Ile Trp Met Cys Ile Val Phe Ala Tyr Ile Gly Val Ser Val Val 
545                 550                 555                 560 


Leu Phe Leu Val Ser Arg Phe Ser Pro Tyr Glu Trp His Thr Glu Glu 
                565                 570                 575     


Phe Glu Asp Gly Arg Glu Thr Gln Ser Ser Glu Ser Thr Asn Glu Phe 
            580                 585                 590         


Gly Ile Phe Asn Ser Leu Trp Phe Ser Leu Gly Ala Phe Met Gln Gln 
        595                 600                 605             


Gly Cys Asp Ile Ser Pro Arg Ser Leu Ser Gly Arg Ile Val Gly Gly 
    610                 615                 620                 


Val Trp Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn 
625                 630                 635                 640 


Leu Ala Ala Phe Leu Thr Val Glu Arg Met Val Ser Pro Ile Glu Ser 
                645                 650                 655     


Ala Glu Asp Leu Ser Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu Asp 
            660                 665                 670         


Ser Gly Ser Thr Lys Glu Phe Phe Arg Arg Ser Lys Ile Ala Val Phe 
        675                 680                 685             


Asp Lys Met Trp Thr Tyr Met Arg Ser Ala Glu Pro Ser Val Phe Val 
    690                 695                 700                 


Arg Thr Thr Ala Glu Gly Val Ala Arg Val Arg Lys Ser Lys Gly Lys 
705                 710                 715                 720 


Tyr Ala Tyr Leu Leu Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln Arg 
                725                 730                 735     


Lys Pro Cys Asp Thr Met Lys Val Gly Gly Asn Leu Asp Ser Lys Gly 
            740                 745                 750         


Tyr Gly Ile Ala Thr Pro Lys Gly Ser Ser Leu Arg Asn Ala Val Asn 
        755                 760                 765             


Leu Ala Val Leu Lys Leu Asn Glu Gln Gly Leu Leu Asp Lys Leu Lys 
    770                 775                 780                 


Asn Lys Trp Trp Tyr Asp Lys Gly Glu Cys Gly Ser Gly Gly Gly Asp 
785                 790                 795                 800 


Ser Lys Glu Lys Thr Ser Ala Leu Ser Leu Ser Asn Val Ala Gly Val 
                805                 810                 815     


Phe Tyr Ile Leu Val Gly Gly Leu Gly Leu Ala Met Leu Val Ala Leu 
            820                 825                 830         


Ile Glu Phe Cys Tyr Lys Ser Arg Ala Glu Ala Lys Arg Met Lys Val 
        835                 840                 845             


Ala Lys Asn Ala Gln Asn Ile Asn Pro Ser Ser Ser Gln Asn Ser Gln 
    850                 855                 860                 


Asn Phe Ala Thr Tyr Lys Glu Gly Tyr Asn Val Tyr Gly Ile Glu Ser 
865                 870                 875                 880 


Val Lys Ile 
            


<210>  6196
<211>  883
<212>  PRT
<213>  Homo Sapiens

<400>  6196

Met Gln Lys Ile Met His Ile Ser Val Leu Leu Ser Pro Val Leu Trp 
1               5                   10                  15      


Gly Leu Ile Phe Gly Val Ser Ser Asn Ser Ile Gln Ile Gly Gly Leu 
            20                  25                  30          


Phe Pro Arg Gly Ala Asp Gln Glu Tyr Ser Ala Phe Arg Val Gly Met 
        35                  40                  45              


Val Gln Phe Ser Thr Ser Glu Phe Arg Leu Thr Pro His Ile Asp Asn 
    50                  55                  60                  


Leu Glu Val Ala Asn Ser Phe Ala Val Thr Asn Ala Phe Cys Ser Gln 
65                  70                  75                  80  


Phe Ser Arg Gly Val Tyr Ala Ile Phe Gly Phe Tyr Asp Lys Lys Ser 
                85                  90                  95      


Val Asn Thr Ile Thr Ser Phe Cys Gly Thr Leu His Val Ser Phe Ile 
            100                 105                 110         


Thr Pro Ser Phe Pro Thr Asp Gly Thr His Pro Phe Val Ile Gln Met 
        115                 120                 125             


Arg Pro Asp Leu Lys Gly Ala Leu Leu Ser Leu Ile Glu Tyr Tyr Gln 
    130                 135                 140                 


Trp Asp Lys Phe Ala Tyr Leu Tyr Asp Ser Asp Arg Gly Leu Ser Thr 
145                 150                 155                 160 


Leu Gln Ala Val Leu Asp Ser Ala Ala Glu Lys Lys Trp Gln Val Thr 
                165                 170                 175     


Ala Ile Asn Val Gly Asn Ile Asn Asn Asp Lys Lys Asp Glu Met Tyr 
            180                 185                 190         


Arg Ser Leu Phe Gln Asp Leu Glu Leu Lys Lys Glu Arg Arg Val Ile 
        195                 200                 205             


Leu Asp Cys Glu Arg Asp Lys Val Asn Asp Ile Val Asp Gln Val Ile 
    210                 215                 220                 


Thr Ile Gly Lys His Val Lys Gly Tyr His Tyr Ile Ile Ala Asn Leu 
225                 230                 235                 240 


Gly Phe Thr Asp Gly Asp Leu Leu Lys Ile Gln Phe Gly Gly Ala Asn 
                245                 250                 255     


Val Ser Gly Phe Gln Ile Val Asp Tyr Asp Asp Ser Leu Val Ser Lys 
            260                 265                 270         


Phe Ile Glu Arg Trp Ser Thr Leu Glu Glu Lys Glu Tyr Pro Gly Ala 
        275                 280                 285             


His Thr Thr Thr Ile Lys Tyr Thr Ser Ala Leu Thr Tyr Asp Ala Val 
    290                 295                 300                 


Gln Val Met Thr Glu Ala Phe Arg Asn Leu Arg Lys Gln Arg Ile Glu 
305                 310                 315                 320 


Ile Ser Arg Arg Gly Asn Ala Gly Asp Cys Leu Ala Asn Pro Ala Val 
                325                 330                 335     


Pro Trp Gly Gln Gly Val Glu Ile Glu Arg Ala Leu Lys Gln Val Gln 
            340                 345                 350         


Val Glu Gly Leu Ser Gly Asn Ile Lys Phe Asp Gln Asn Gly Lys Arg 
        355                 360                 365             


Ile Asn Tyr Thr Ile Asn Ile Met Glu Leu Lys Thr Asn Gly Pro Arg 
    370                 375                 380                 


Lys Ile Gly Tyr Trp Ser Glu Val Asp Lys Met Val Val Thr Leu Thr 
385                 390                 395                 400 


Glu Leu Pro Ser Gly Asn Asp Thr Ser Gly Leu Glu Asn Lys Thr Val 
                405                 410                 415     


Val Val Thr Thr Ile Leu Glu Ser Pro Tyr Val Met Met Lys Lys Asn 
            420                 425                 430         


His Glu Met Leu Glu Gly Asn Glu Arg Tyr Glu Gly Tyr Cys Val Asp 
        435                 440                 445             


Leu Ala Ala Glu Ile Ala Lys His Cys Gly Phe Lys Tyr Lys Leu Thr 
    450                 455                 460                 


Ile Val Gly Asp Gly Lys Tyr Gly Ala Arg Asp Ala Asp Thr Lys Ile 
465                 470                 475                 480 


Trp Asn Gly Met Val Gly Glu Leu Val Tyr Gly Lys Ala Asp Ile Ala 
                485                 490                 495     


Ile Ala Pro Leu Thr Ile Thr Leu Val Arg Glu Glu Val Ile Asp Phe 
            500                 505                 510         


Ser Lys Pro Phe Met Ser Leu Gly Ile Ser Ile Met Ile Lys Lys Pro 
        515                 520                 525             


Gln Lys Ser Lys Pro Gly Val Phe Ser Phe Leu Asp Pro Leu Ala Tyr 
    530                 535                 540                 


Glu Ile Trp Met Cys Ile Val Phe Ala Tyr Ile Gly Val Ser Val Val 
545                 550                 555                 560 


Leu Phe Leu Val Ser Arg Phe Ser Pro Tyr Glu Trp His Thr Glu Glu 
                565                 570                 575     


Phe Glu Asp Gly Arg Glu Thr Gln Ser Ser Glu Ser Thr Asn Glu Phe 
            580                 585                 590         


Gly Ile Phe Asn Ser Leu Trp Phe Ser Leu Gly Ala Phe Met Gln Gln 
        595                 600                 605             


Gly Cys Asp Ile Ser Pro Arg Ser Leu Ser Gly Arg Ile Val Gly Gly 
    610                 615                 620                 


Val Trp Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn 
625                 630                 635                 640 


Leu Ala Ala Phe Leu Thr Val Glu Arg Met Val Ser Pro Ile Glu Ser 
                645                 650                 655     


Ala Glu Asp Leu Ser Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu Asp 
            660                 665                 670         


Ser Gly Ser Thr Lys Glu Phe Phe Arg Arg Ser Lys Ile Ala Val Phe 
        675                 680                 685             


Asp Lys Met Trp Thr Tyr Met Arg Ser Ala Glu Pro Ser Val Phe Val 
    690                 695                 700                 


Arg Thr Thr Ala Glu Gly Val Ala Arg Val Arg Lys Ser Lys Gly Lys 
705                 710                 715                 720 


Tyr Ala Tyr Leu Leu Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln Arg 
                725                 730                 735     


Lys Pro Cys Asp Thr Met Lys Val Gly Gly Asn Leu Asp Ser Lys Gly 
            740                 745                 750         


Tyr Gly Ile Ala Thr Pro Lys Gly Ser Ser Leu Arg Thr Pro Val Asn 
        755                 760                 765             


Leu Ala Val Leu Lys Leu Ser Glu Gln Gly Val Leu Asp Lys Leu Lys 
    770                 775                 780                 


Asn Lys Trp Trp Tyr Asp Lys Gly Glu Cys Gly Ala Lys Asp Ser Gly 
785                 790                 795                 800 


Ser Lys Glu Lys Thr Ser Ala Leu Ser Leu Ser Asn Val Ala Gly Val 
                805                 810                 815     


Phe Tyr Ile Leu Val Gly Gly Leu Gly Leu Ala Met Leu Val Ala Leu 
            820                 825                 830         


Ile Glu Phe Cys Tyr Lys Ser Arg Ala Glu Ala Lys Arg Met Lys Val 
        835                 840                 845             


Ala Lys Asn Ala Gln Asn Ile Asn Pro Ser Ser Ser Gln Asn Ser Gln 
    850                 855                 860                 


Asn Phe Ala Thr Tyr Lys Glu Gly Tyr Asn Val Tyr Gly Ile Glu Ser 
865                 870                 875                 880 


Val Lys Ile 
            


<210>  6197
<211>  901
<212>  PRT
<213>  Homo Sapiens

<400>  6197

Met Gln Lys Ile Met His Ile Ser Val Leu Leu Ser Pro Val Leu Trp 
1               5                   10                  15      


Gly Leu Ile Phe Gly Val Ser Ser Asn Ser Ile Gln Ile Gly Gly Leu 
            20                  25                  30          


Phe Pro Arg Gly Ala Asp Gln Glu Tyr Ser Ala Phe Arg Val Gly Met 
        35                  40                  45              


Val Gln Phe Ser Thr Ser Glu Phe Arg Leu Thr Pro His Ile Asp Asn 
    50                  55                  60                  


Leu Glu Val Ala Asn Ser Phe Ala Val Thr Asn Ala Phe Cys Ser Gln 
65                  70                  75                  80  


Phe Ser Arg Gly Val Tyr Ala Ile Phe Gly Phe Tyr Asp Lys Lys Ser 
                85                  90                  95      


Val Asn Thr Ile Thr Ser Phe Cys Gly Thr Leu His Val Ser Phe Ile 
            100                 105                 110         


Thr Pro Ser Phe Pro Thr Asp Gly Thr His Pro Phe Val Ile Gln Met 
        115                 120                 125             


Arg Pro Asp Leu Lys Gly Ala Leu Leu Ser Leu Ile Glu Tyr Tyr Gln 
    130                 135                 140                 


Trp Asp Lys Phe Ala Tyr Leu Tyr Asp Ser Asp Arg Gly Leu Ser Thr 
145                 150                 155                 160 


Leu Gln Ala Val Leu Asp Ser Ala Ala Glu Lys Lys Trp Gln Val Thr 
                165                 170                 175     


Ala Ile Asn Val Gly Asn Ile Asn Asn Asp Lys Lys Asp Glu Met Tyr 
            180                 185                 190         


Arg Ser Leu Phe Gln Asp Leu Glu Leu Lys Lys Glu Arg Arg Val Ile 
        195                 200                 205             


Leu Asp Cys Glu Arg Asp Lys Val Asn Asp Ile Val Asp Gln Val Ile 
    210                 215                 220                 


Thr Ile Gly Lys His Val Lys Gly Tyr His Tyr Ile Ile Ala Asn Leu 
225                 230                 235                 240 


Gly Phe Thr Asp Gly Asp Leu Leu Lys Ile Gln Phe Gly Gly Ala Asn 
                245                 250                 255     


Val Ser Gly Phe Gln Ile Val Asp Tyr Asp Asp Ser Leu Val Ser Lys 
            260                 265                 270         


Phe Ile Glu Arg Trp Ser Thr Leu Glu Glu Lys Glu Tyr Pro Gly Ala 
        275                 280                 285             


His Thr Thr Thr Ile Lys Tyr Thr Ser Ala Leu Thr Tyr Asp Ala Val 
    290                 295                 300                 


Gln Val Met Thr Glu Ala Phe Arg Asn Leu Arg Lys Gln Arg Ile Glu 
305                 310                 315                 320 


Ile Ser Arg Arg Gly Asn Ala Gly Asp Cys Leu Ala Asn Pro Ala Val 
                325                 330                 335     


Pro Trp Gly Gln Gly Val Glu Ile Glu Arg Ala Leu Lys Gln Val Gln 
            340                 345                 350         


Val Glu Gly Leu Ser Gly Asn Ile Lys Phe Asp Gln Asn Gly Lys Arg 
        355                 360                 365             


Ile Asn Tyr Thr Ile Asn Ile Met Glu Leu Lys Thr Asn Gly Pro Arg 
    370                 375                 380                 


Lys Ile Gly Tyr Trp Ser Glu Val Asp Lys Met Val Val Thr Leu Thr 
385                 390                 395                 400 


Glu Leu Pro Ser Gly Asn Asp Thr Ser Gly Leu Glu Asn Lys Thr Val 
                405                 410                 415     


Val Val Thr Thr Ile Leu Glu Ser Pro Tyr Val Met Met Lys Lys Asn 
            420                 425                 430         


His Glu Met Leu Glu Gly Asn Glu Arg Tyr Glu Gly Tyr Cys Val Asp 
        435                 440                 445             


Leu Ala Ala Glu Ile Ala Lys His Cys Gly Phe Lys Tyr Lys Leu Thr 
    450                 455                 460                 


Ile Val Gly Asp Gly Lys Tyr Gly Ala Arg Asp Ala Asp Thr Lys Ile 
465                 470                 475                 480 


Trp Asn Gly Met Val Gly Glu Leu Val Tyr Gly Lys Ala Asp Ile Ala 
                485                 490                 495     


Ile Ala Pro Leu Thr Ile Thr Leu Val Arg Glu Glu Val Ile Asp Phe 
            500                 505                 510         


Ser Lys Pro Phe Met Ser Leu Gly Ile Ser Ile Met Ile Lys Lys Pro 
        515                 520                 525             


Gln Lys Ser Lys Pro Gly Val Phe Ser Phe Leu Asp Pro Leu Ala Tyr 
    530                 535                 540                 


Glu Ile Trp Met Cys Ile Val Phe Ala Tyr Ile Gly Val Ser Val Val 
545                 550                 555                 560 


Leu Phe Leu Val Ser Arg Phe Ser Pro Tyr Glu Trp His Thr Glu Glu 
                565                 570                 575     


Phe Glu Asp Gly Arg Glu Thr Gln Ser Ser Glu Ser Thr Asn Glu Phe 
            580                 585                 590         


Gly Ile Phe Asn Ser Leu Trp Phe Ser Leu Gly Ala Phe Met Gln Gln 
        595                 600                 605             


Gly Cys Asp Ile Ser Pro Arg Ser Leu Ser Gly Arg Ile Val Gly Gly 
    610                 615                 620                 


Val Trp Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn 
625                 630                 635                 640 


Leu Ala Ala Phe Leu Thr Val Glu Arg Met Val Ser Pro Ile Glu Ser 
                645                 650                 655     


Ala Glu Asp Leu Ser Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu Asp 
            660                 665                 670         


Ser Gly Ser Thr Lys Glu Phe Phe Arg Arg Ser Lys Ile Ala Val Phe 
        675                 680                 685             


Asp Lys Met Trp Thr Tyr Met Arg Ser Ala Glu Pro Ser Val Phe Val 
    690                 695                 700                 


Arg Thr Thr Ala Glu Gly Val Ala Arg Val Arg Lys Ser Lys Gly Lys 
705                 710                 715                 720 


Tyr Ala Tyr Leu Leu Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln Arg 
                725                 730                 735     


Lys Pro Cys Asp Thr Met Lys Val Gly Gly Asn Leu Asp Ser Lys Gly 
            740                 745                 750         


Tyr Gly Ile Ala Thr Pro Lys Gly Ser Ser Leu Arg Asn Ala Val Asn 
        755                 760                 765             


Leu Ala Val Leu Lys Leu Asn Glu Gln Gly Leu Leu Asp Lys Leu Lys 
    770                 775                 780                 


Asn Lys Trp Trp Tyr Asp Lys Gly Glu Cys Gly Ser Gly Gly Gly Asp 
785                 790                 795                 800 


Ser Lys Glu Lys Thr Ser Ala Leu Ser Leu Ser Asn Val Ala Gly Val 
                805                 810                 815     


Phe Tyr Ile Leu Val Gly Gly Leu Gly Leu Ala Met Leu Val Ala Leu 
            820                 825                 830         


Ile Glu Phe Cys Tyr Lys Ser Arg Ala Glu Ala Lys Arg Met Lys Met 
        835                 840                 845             


Thr Leu Asn Asp Ala Met Arg Asn Lys Ala Arg Leu Ser Ile Thr Gly 
    850                 855                 860                 


Ser Thr Gly Glu Asn Gly Arg Val Met Thr Pro Glu Phe Pro Lys Ala 
865                 870                 875                 880 


Val His Ala Val Pro Tyr Val Ser Pro Gly Met Gly Met Asn Val Ser 
                885                 890                 895     


Val Thr Asp Leu Ser 
            900     


<210>  6198
<211>  105
<212>  PRT
<213>  Homo Sapiens

<400>  6198

Met Arg Pro Asp Leu Lys Gly Ala Leu Leu Ser Leu Ile Glu Tyr Tyr 
1               5                   10                  15      


Gln Trp Asp Lys Phe Ala Tyr Leu Tyr Asp Ser Asp Arg Gly Leu Ser 
            20                  25                  30          


Thr Leu Gln Ala Val Leu Asp Ser Ala Ala Glu Lys Lys Trp Gln Val 
        35                  40                  45              


Thr Ala Ile Asn Val Gly Asn Ile Asn Asn Asp Lys Lys Asp Glu Met 
    50                  55                  60                  


Tyr Arg Ser Leu Phe Gln Asp Leu Glu Leu Lys Lys Glu Arg Arg Val 
65                  70                  75                  80  


Ile Leu Asp Cys Glu Arg Asp Lys Val Asn Asp Ile Val Asp Gln Val 
                85                  90                  95      


Ile Thr Ile Gly Lys His Val Lys Gly 
            100                 105 


<210>  6199
<211>  57
<212>  PRT
<213>  Homo Sapiens

<400>  6199

Met Val Gln Phe Ser Thr Ser Glu Phe Arg Leu Thr Pro His Ile Asp 
1               5                   10                  15      


Asn Leu Glu Val Ala Asn Ser Phe Ala Val Thr Asn Ala Phe Cys Ser 
            20                  25                  30          


Gln Phe Ser Arg Gly Val Tyr Ala Ile Phe Gly Phe Tyr Asp Lys Lys 
        35                  40                  45              


Ser Val Asn Thr Ile Thr Ser Phe Cys 
    50                  55          


<210>  6200
<211>  145
<212>  PRT
<213>  Homo Sapiens

<400>  6200

Met Val Gln Phe Ser Thr Ser Glu Phe Arg Leu Thr Pro His Ile Asp 
1               5                   10                  15      


Asn Leu Glu Val Ala Asn Ser Phe Ala Val Thr Asn Ala Phe Cys Ser 
            20                  25                  30          


Gln Phe Ser Arg Gly Val Tyr Ala Ile Phe Gly Phe Tyr Asp Lys Lys 
        35                  40                  45              


Ser Val Asn Thr Ile Thr Ser Phe Cys Gly Thr Leu His Val Ser Phe 
    50                  55                  60                  


Ile Thr Pro Ser Phe Pro Thr Asp Gly Thr His Pro Phe Val Ile Gln 
65                  70                  75                  80  


Met Arg Pro Asp Leu Lys Gly Ala Leu Leu Ser Leu Ile Glu Tyr Tyr 
                85                  90                  95      


Gln Trp Asp Lys Phe Ala Tyr Leu Tyr Asp Ser Asp Arg Gly Leu Ser 
            100                 105                 110         


Thr Leu Gln Ala Val Leu Asp Ser Ala Ala Glu Lys Lys Trp Gln Val 
        115                 120                 125             


Thr Ala Ile Asn Val Gly Asn Ile Asn Asn Asp Lys Lys Asp Glu Met 
    130                 135                 140                 


Tyr 
145 


<210>  6201
<211>  730
<212>  PRT
<213>  Homo Sapiens

<400>  6201

Met Val Gln Phe Ser Thr Ser Glu Phe Arg Leu Thr Pro His Ile Asp 
1               5                   10                  15      


Asn Leu Glu Val Ala Asn Ser Phe Ala Val Thr Asn Ala Phe Cys Ser 
            20                  25                  30          


Gln Phe Ser Arg Gly Val Tyr Ala Ile Phe Gly Phe Tyr Asp Lys Lys 
        35                  40                  45              


Ser Val Asn Thr Ile Thr Ser Phe Cys Gly Thr Leu His Val Ser Phe 
    50                  55                  60                  


Ile Thr Pro Ser Phe Pro Thr Asp Gly Thr His Pro Phe Val Ile Gln 
65                  70                  75                  80  


Met Arg Pro Asp Leu Lys Gly Ala Leu Leu Ser Leu Ile Glu Tyr Tyr 
                85                  90                  95      


Gln Trp Asp Lys Phe Ala Tyr Leu Tyr Asp Ser Asp Arg Gly Leu Ser 
            100                 105                 110         


Thr Leu Gln Ala Val Leu Asp Ser Ala Ala Glu Lys Lys Trp Gln Val 
        115                 120                 125             


Thr Ala Ile Asn Val Gly Asn Ile Asn Asn Asp Lys Lys Asp Glu Met 
    130                 135                 140                 


Tyr Arg Ser Leu Phe Gln Asp Leu Glu Leu Lys Lys Glu Arg Arg Val 
145                 150                 155                 160 


Ile Leu Asp Cys Glu Arg Asp Lys Val Asn Asp Ile Val Asp Gln Val 
                165                 170                 175     


Ile Thr Ile Gly Lys His Val Lys Gly Tyr His Tyr Ile Ile Ala Asn 
            180                 185                 190         


Leu Gly Phe Thr Asp Gly Asp Leu Leu Lys Ile Gln Phe Gly Gly Ala 
        195                 200                 205             


Asn Val Ser Gly Phe Gln Ile Val Asp Tyr Asp Asp Ser Leu Val Ser 
    210                 215                 220                 


Lys Phe Ile Glu Arg Trp Ser Thr Leu Glu Glu Lys Glu Tyr Pro Gly 
225                 230                 235                 240 


Ala His Thr Thr Thr Ile Lys Tyr Thr Ser Ala Leu Thr Tyr Asp Ala 
                245                 250                 255     


Val Gln Val Met Thr Glu Ala Phe Arg Asn Leu Arg Lys Gln Arg Ile 
            260                 265                 270         


Glu Ile Ser Arg Arg Gly Asn Ala Gly Asp Cys Leu Ala Asn Pro Ala 
        275                 280                 285             


Val Pro Trp Gly Gln Gly Val Glu Ile Glu Arg Ala Leu Lys Gln Val 
    290                 295                 300                 


Gln Val Glu Gly Leu Ser Gly Asn Ile Lys Phe Asp Gln Asn Gly Lys 
305                 310                 315                 320 


Arg Ile Asn Tyr Thr Ile Asn Ile Met Glu Leu Lys Thr Asn Gly Pro 
                325                 330                 335     


Arg Lys Ile Gly Tyr Trp Ser Glu Val Asp Lys Met Val Val Thr Leu 
            340                 345                 350         


Thr Glu Leu Pro Ser Gly Asn Asp Thr Ser Gly Leu Glu Asn Lys Thr 
        355                 360                 365             


Val Val Val Thr Thr Ile Leu Glu Ser Pro Tyr Val Met Met Lys Lys 
    370                 375                 380                 


Asn His Glu Met Leu Glu Gly Asn Glu Arg Tyr Glu Gly Tyr Cys Val 
385                 390                 395                 400 


Asp Leu Ala Ala Glu Ile Ala Lys His Cys Gly Phe Lys Tyr Lys Leu 
                405                 410                 415     


Thr Ile Val Gly Asp Gly Lys Tyr Gly Ala Arg Asp Ala Asp Thr Lys 
            420                 425                 430         


Ile Trp Asn Gly Met Val Gly Glu Leu Val Tyr Gly Lys Ala Asp Ile 
        435                 440                 445             


Ala Ile Ala Pro Leu Thr Ile Thr Leu Val Arg Glu Glu Val Ile Asp 
    450                 455                 460                 


Phe Ser Lys Pro Phe Met Ser Leu Gly Ile Ser Ile Met Ile Lys Lys 
465                 470                 475                 480 


Pro Gln Lys Ser Lys Pro Gly Val Phe Ser Phe Leu Asp Pro Leu Ala 
                485                 490                 495     


Tyr Glu Ile Trp Met Cys Ile Val Phe Ala Tyr Ile Gly Val Ser Val 
            500                 505                 510         


Val Leu Phe Leu Val Ser Arg Phe Ser Pro Tyr Glu Trp His Thr Glu 
        515                 520                 525             


Glu Phe Glu Asp Gly Arg Glu Thr Gln Ser Ser Glu Ser Thr Asn Glu 
    530                 535                 540                 


Phe Gly Ile Phe Asn Ser Leu Trp Phe Ser Leu Gly Ala Phe Met Gln 
545                 550                 555                 560 


Gln Gly Cys Asp Ile Ser Pro Arg Ser Leu Ser Gly Arg Ile Val Gly 
                565                 570                 575     


Gly Val Trp Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala 
            580                 585                 590         


Asn Leu Ala Ala Phe Leu Thr Val Glu Arg Met Val Ser Pro Ile Glu 
        595                 600                 605             


Ser Ala Glu Asp Leu Ser Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu 
    610                 615                 620                 


Asp Ser Gly Ser Thr Lys Glu Phe Phe Arg Arg Ser Lys Ile Ala Val 
625                 630                 635                 640 


Phe Asp Lys Met Trp Thr Tyr Met Arg Ser Ala Glu Pro Ser Val Phe 
                645                 650                 655     


Val Arg Thr Thr Ala Glu Gly Val Ala Arg Val Arg Lys Ser Lys Gly 
            660                 665                 670         


Lys Tyr Ala Tyr Leu Leu Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln 
        675                 680                 685             


Arg Lys Pro Cys Asp Thr Met Lys Val Gly Gly Asn Leu Asp Ser Lys 
    690                 695                 700                 


Gly Tyr Gly Ile Ala Thr Pro Lys Gly Ser Ser Leu Ser Gly Val Thr 
705                 710                 715                 720 


Phe Lys Thr Leu Leu Phe Val Cys Cys Gly 
                725                 730 


<210>  6202
<211>  836
<212>  PRT
<213>  Homo Sapiens

<400>  6202

Met Val Gln Phe Ser Thr Ser Glu Phe Arg Leu Thr Pro His Ile Asp 
1               5                   10                  15      


Asn Leu Glu Val Ala Asn Ser Phe Ala Val Thr Asn Ala Phe Cys Ser 
            20                  25                  30          


Gln Phe Ser Arg Gly Val Tyr Ala Ile Phe Gly Phe Tyr Asp Lys Lys 
        35                  40                  45              


Ser Val Asn Thr Ile Thr Ser Phe Cys Gly Thr Leu His Val Ser Phe 
    50                  55                  60                  


Ile Thr Pro Ser Phe Pro Thr Asp Gly Thr His Pro Phe Val Ile Gln 
65                  70                  75                  80  


Met Arg Pro Asp Leu Lys Gly Ala Leu Leu Ser Leu Ile Glu Tyr Tyr 
                85                  90                  95      


Gln Trp Asp Lys Phe Ala Tyr Leu Tyr Asp Ser Asp Arg Gly Leu Ser 
            100                 105                 110         


Thr Leu Gln Ala Val Leu Asp Ser Ala Ala Glu Lys Lys Trp Gln Val 
        115                 120                 125             


Thr Ala Ile Asn Val Gly Asn Ile Asn Asn Asp Lys Lys Asp Glu Met 
    130                 135                 140                 


Tyr Arg Ser Leu Phe Gln Asp Leu Glu Leu Lys Lys Glu Arg Arg Val 
145                 150                 155                 160 


Ile Leu Asp Cys Glu Arg Asp Lys Val Asn Asp Ile Val Asp Gln Val 
                165                 170                 175     


Ile Thr Ile Gly Lys His Val Lys Gly Tyr His Tyr Ile Ile Ala Asn 
            180                 185                 190         


Leu Gly Phe Thr Asp Gly Asp Leu Leu Lys Ile Gln Phe Gly Gly Ala 
        195                 200                 205             


Asn Val Ser Gly Phe Gln Ile Val Asp Tyr Asp Asp Ser Leu Val Ser 
    210                 215                 220                 


Lys Phe Ile Glu Arg Trp Ser Thr Leu Glu Glu Lys Glu Tyr Pro Gly 
225                 230                 235                 240 


Ala His Thr Thr Thr Ile Lys Tyr Thr Ser Ala Leu Thr Tyr Asp Ala 
                245                 250                 255     


Val Gln Val Met Thr Glu Ala Phe Arg Asn Leu Arg Lys Gln Arg Ile 
            260                 265                 270         


Glu Ile Ser Arg Arg Gly Asn Ala Gly Asp Cys Leu Ala Asn Pro Ala 
        275                 280                 285             


Val Pro Trp Gly Gln Gly Val Glu Ile Glu Arg Ala Leu Lys Gln Val 
    290                 295                 300                 


Gln Val Glu Gly Leu Ser Gly Asn Ile Lys Phe Asp Gln Asn Gly Lys 
305                 310                 315                 320 


Arg Ile Asn Tyr Thr Ile Asn Ile Met Glu Leu Lys Thr Asn Gly Pro 
                325                 330                 335     


Arg Lys Ile Gly Tyr Trp Ser Glu Val Asp Lys Met Val Val Thr Leu 
            340                 345                 350         


Thr Glu Leu Pro Ser Gly Asn Asp Thr Ser Gly Leu Glu Asn Lys Thr 
        355                 360                 365             


Val Val Val Thr Thr Ile Leu Glu Ser Pro Tyr Val Met Met Lys Lys 
    370                 375                 380                 


Asn His Glu Met Leu Glu Gly Asn Glu Arg Tyr Glu Gly Tyr Cys Val 
385                 390                 395                 400 


Asp Leu Ala Ala Glu Ile Ala Lys His Cys Gly Phe Lys Tyr Lys Leu 
                405                 410                 415     


Thr Ile Val Gly Asp Gly Lys Tyr Gly Ala Arg Asp Ala Asp Thr Lys 
            420                 425                 430         


Ile Trp Asn Gly Met Val Gly Glu Leu Val Tyr Gly Lys Ala Asp Ile 
        435                 440                 445             


Ala Ile Ala Pro Leu Thr Ile Thr Leu Val Arg Glu Glu Val Ile Asp 
    450                 455                 460                 


Phe Ser Lys Pro Phe Met Ser Leu Gly Ile Ser Ile Met Ile Lys Lys 
465                 470                 475                 480 


Pro Gln Lys Ser Lys Pro Gly Val Phe Ser Phe Leu Asp Pro Leu Ala 
                485                 490                 495     


Tyr Glu Ile Trp Met Cys Ile Val Phe Ala Tyr Ile Gly Val Ser Val 
            500                 505                 510         


Val Leu Phe Leu Val Ser Arg Phe Ser Pro Tyr Glu Trp His Thr Glu 
        515                 520                 525             


Glu Phe Glu Asp Gly Arg Glu Thr Gln Ser Ser Glu Ser Thr Asn Glu 
    530                 535                 540                 


Phe Gly Ile Phe Asn Ser Leu Trp Phe Ser Leu Gly Ala Phe Met Gln 
545                 550                 555                 560 


Gln Gly Cys Asp Ile Ser Pro Arg Ser Leu Ser Gly Arg Ile Val Gly 
                565                 570                 575     


Gly Val Trp Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala 
            580                 585                 590         


Asn Leu Ala Ala Phe Leu Thr Val Glu Arg Met Val Ser Pro Ile Glu 
        595                 600                 605             


Ser Ala Glu Asp Leu Ser Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu 
    610                 615                 620                 


Asp Ser Gly Ser Thr Lys Glu Phe Phe Arg Arg Ser Lys Ile Ala Val 
625                 630                 635                 640 


Phe Asp Lys Met Trp Thr Tyr Met Arg Ser Ala Glu Pro Ser Val Phe 
                645                 650                 655     


Val Arg Thr Thr Ala Glu Gly Val Ala Arg Val Arg Lys Ser Lys Gly 
            660                 665                 670         


Lys Tyr Ala Tyr Leu Leu Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln 
        675                 680                 685             


Arg Lys Pro Cys Asp Thr Met Lys Val Gly Gly Asn Leu Asp Ser Lys 
    690                 695                 700                 


Gly Tyr Gly Ile Ala Thr Pro Lys Gly Ser Ser Leu Arg Thr Pro Val 
705                 710                 715                 720 


Asn Leu Ala Val Leu Lys Leu Ser Glu Gln Gly Val Leu Asp Lys Leu 
                725                 730                 735     


Lys Asn Lys Trp Trp Tyr Asp Lys Gly Glu Cys Gly Ala Lys Asp Ser 
            740                 745                 750         


Gly Ser Lys Glu Lys Thr Ser Ala Leu Ser Leu Ser Asn Val Ala Gly 
        755                 760                 765             


Val Phe Tyr Ile Leu Val Gly Gly Leu Gly Leu Ala Met Leu Val Ala 
    770                 775                 780                 


Leu Ile Glu Phe Cys Tyr Lys Ser Arg Ala Glu Ala Lys Arg Met Lys 
785                 790                 795                 800 


Val Ala Lys Asn Ala Gln Asn Ile Asn Pro Ser Ser Ser Gln Asn Ser 
                805                 810                 815     


Gln Asn Phe Ala Thr Tyr Lys Glu Gly Tyr Asn Val Tyr Gly Ile Glu 
            820                 825                 830         


Ser Val Lys Ile 
        835     


<210>  6203
<211>  836
<212>  PRT
<213>  Homo Sapiens

<400>  6203

Met Val Gln Phe Ser Thr Ser Glu Phe Arg Leu Thr Pro His Ile Asp 
1               5                   10                  15      


Asn Leu Glu Val Ala Asn Ser Phe Ala Val Thr Asn Ala Phe Cys Ser 
            20                  25                  30          


Gln Phe Ser Arg Gly Val Tyr Ala Ile Phe Gly Phe Tyr Asp Lys Lys 
        35                  40                  45              


Ser Val Asn Thr Ile Thr Ser Phe Cys Gly Thr Leu His Val Ser Phe 
    50                  55                  60                  


Ile Thr Pro Ser Phe Pro Thr Asp Gly Thr His Pro Phe Val Ile Gln 
65                  70                  75                  80  


Met Arg Pro Asp Leu Lys Gly Ala Leu Leu Ser Leu Ile Glu Tyr Tyr 
                85                  90                  95      


Gln Trp Asp Lys Phe Ala Tyr Leu Tyr Asp Ser Asp Arg Gly Leu Ser 
            100                 105                 110         


Thr Leu Gln Ala Val Leu Asp Ser Ala Ala Glu Lys Lys Trp Gln Val 
        115                 120                 125             


Thr Ala Ile Asn Val Gly Asn Ile Asn Asn Asp Lys Lys Asp Glu Met 
    130                 135                 140                 


Tyr Arg Ser Leu Phe Gln Asp Leu Glu Leu Lys Lys Glu Arg Arg Val 
145                 150                 155                 160 


Ile Leu Asp Cys Glu Arg Asp Lys Val Asn Asp Ile Val Asp Gln Val 
                165                 170                 175     


Ile Thr Ile Gly Lys His Val Lys Gly Tyr His Tyr Ile Ile Ala Asn 
            180                 185                 190         


Leu Gly Phe Thr Asp Gly Asp Leu Leu Lys Ile Gln Phe Gly Gly Ala 
        195                 200                 205             


Asn Val Ser Gly Phe Gln Ile Val Asp Tyr Asp Asp Ser Leu Val Ser 
    210                 215                 220                 


Lys Phe Ile Glu Arg Trp Ser Thr Leu Glu Glu Lys Glu Tyr Pro Gly 
225                 230                 235                 240 


Ala His Thr Thr Thr Ile Lys Tyr Thr Ser Ala Leu Thr Tyr Asp Ala 
                245                 250                 255     


Val Gln Val Met Thr Glu Ala Phe Arg Asn Leu Arg Lys Gln Arg Ile 
            260                 265                 270         


Glu Ile Ser Arg Arg Gly Asn Ala Gly Asp Cys Leu Ala Asn Pro Ala 
        275                 280                 285             


Val Pro Trp Gly Gln Gly Val Glu Ile Glu Arg Ala Leu Lys Gln Val 
    290                 295                 300                 


Gln Val Glu Gly Leu Ser Gly Asn Ile Lys Phe Asp Gln Asn Gly Lys 
305                 310                 315                 320 


Arg Ile Asn Tyr Thr Ile Asn Ile Met Glu Leu Lys Thr Asn Gly Pro 
                325                 330                 335     


Arg Lys Ile Gly Tyr Trp Ser Glu Val Asp Lys Met Val Val Thr Leu 
            340                 345                 350         


Thr Glu Leu Pro Ser Gly Asn Asp Thr Ser Gly Leu Glu Asn Lys Thr 
        355                 360                 365             


Val Val Val Thr Thr Ile Leu Glu Ser Pro Tyr Val Met Met Lys Lys 
    370                 375                 380                 


Asn His Glu Met Leu Glu Gly Asn Glu Arg Tyr Glu Gly Tyr Cys Val 
385                 390                 395                 400 


Asp Leu Ala Ala Glu Ile Ala Lys His Cys Gly Phe Lys Tyr Lys Leu 
                405                 410                 415     


Thr Ile Val Gly Asp Gly Lys Tyr Gly Ala Arg Asp Ala Asp Thr Lys 
            420                 425                 430         


Ile Trp Asn Gly Met Val Gly Glu Leu Val Tyr Gly Lys Ala Asp Ile 
        435                 440                 445             


Ala Ile Ala Pro Leu Thr Ile Thr Leu Val Arg Glu Glu Val Ile Asp 
    450                 455                 460                 


Phe Ser Lys Pro Phe Met Ser Leu Gly Ile Ser Ile Met Ile Lys Lys 
465                 470                 475                 480 


Pro Gln Lys Ser Lys Pro Gly Val Phe Ser Phe Leu Asp Pro Leu Ala 
                485                 490                 495     


Tyr Glu Ile Trp Met Cys Ile Val Phe Ala Tyr Ile Gly Val Ser Val 
            500                 505                 510         


Val Leu Phe Leu Val Ser Arg Phe Ser Pro Tyr Glu Trp His Thr Glu 
        515                 520                 525             


Glu Phe Glu Asp Gly Arg Glu Thr Gln Ser Ser Glu Ser Thr Asn Glu 
    530                 535                 540                 


Phe Gly Ile Phe Asn Ser Leu Trp Phe Ser Leu Gly Ala Phe Met Gln 
545                 550                 555                 560 


Gln Gly Cys Asp Ile Ser Pro Arg Ser Leu Ser Gly Arg Ile Val Gly 
                565                 570                 575     


Gly Val Trp Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala 
            580                 585                 590         


Asn Leu Ala Ala Phe Leu Thr Val Glu Arg Met Val Ser Pro Ile Glu 
        595                 600                 605             


Ser Ala Glu Asp Leu Ser Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu 
    610                 615                 620                 


Asp Ser Gly Ser Thr Lys Glu Phe Phe Arg Arg Ser Lys Ile Ala Val 
625                 630                 635                 640 


Phe Asp Lys Met Trp Thr Tyr Met Arg Ser Ala Glu Pro Ser Val Phe 
                645                 650                 655     


Val Arg Thr Thr Ala Glu Gly Val Ala Arg Val Arg Lys Ser Lys Gly 
            660                 665                 670         


Lys Tyr Ala Tyr Leu Leu Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln 
        675                 680                 685             


Arg Lys Pro Cys Asp Thr Met Lys Val Gly Gly Asn Leu Asp Ser Lys 
    690                 695                 700                 


Gly Tyr Gly Ile Ala Thr Pro Lys Gly Ser Ser Leu Arg Thr Pro Val 
705                 710                 715                 720 


Asn Leu Ala Val Leu Lys Leu Ser Glu Gln Gly Val Leu Asp Lys Leu 
                725                 730                 735     


Lys Asn Lys Trp Trp Tyr Asp Lys Gly Glu Cys Gly Ala Lys Asp Ser 
            740                 745                 750         


Gly Ser Lys Glu Lys Thr Ser Ala Leu Ser Leu Ser Asn Val Ala Gly 
        755                 760                 765             


Val Phe Tyr Ile Leu Val Gly Gly Leu Gly Leu Ala Met Leu Val Ala 
    770                 775                 780                 


Leu Ile Glu Phe Cys Tyr Lys Ser Arg Ala Glu Ala Lys Arg Met Lys 
785                 790                 795                 800 


Val Ala Lys Asn Ala Gln Asn Ile Asn Pro Ser Ser Ser Gln Asn Ser 
                805                 810                 815     


Gln Asn Phe Ala Thr Tyr Lys Glu Gly Tyr Asn Val Tyr Gly Ile Glu 
            820                 825                 830         


Ser Val Lys Ile 
        835     


<210>  6204
<211>  214
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6204

Xaa Leu Asp Ser Gly Ser Thr Lys Glu Phe Phe Arg Arg Ser Lys Ile 
1               5                   10                  15      


Ala Val Phe Asp Lys Met Trp Thr Tyr Met Arg Ser Ala Glu Pro Ser 
            20                  25                  30          


Val Phe Val Arg Thr Thr Ala Glu Gly Val Ala Arg Val Arg Lys Ser 
        35                  40                  45              


Lys Gly Lys Tyr Ala Tyr Leu Leu Glu Ser Thr Met Asn Glu Tyr Ile 
    50                  55                  60                  


Glu Gln Arg Lys Pro Cys Asp Thr Met Lys Val Gly Gly Asn Leu Asp 
65                  70                  75                  80  


Ser Lys Gly Tyr Gly Ile Ala Thr Pro Lys Gly Ser Ser Leu Arg Thr 
                85                  90                  95      


Pro Val Asn Leu Ala Val Leu Lys Leu Ser Glu Gln Gly Val Leu Asp 
            100                 105                 110         


Lys Leu Lys Asn Lys Trp Trp Tyr Asp Lys Gly Glu Cys Gly Ala Lys 
        115                 120                 125             


Asp Ser Gly Ser Lys Glu Lys Thr Ser Ala Leu Ser Leu Ser Asn Val 
    130                 135                 140                 


Ala Gly Val Phe Tyr Ile Leu Val Gly Gly Leu Gly Leu Ala Met Leu 
145                 150                 155                 160 


Val Ala Leu Ile Glu Phe Cys Tyr Lys Ser Arg Ala Glu Ala Lys Arg 
                165                 170                 175     


Met Lys Val Ala Lys Asn Ala Gln Asn Ile Asn Pro Ser Ser Ser Gln 
            180                 185                 190         


Asn Ser Gln Asn Phe Ala Thr Tyr Lys Glu Gly Tyr Asn Val Tyr Gly 
        195                 200                 205             


Ile Glu Ser Val Lys Ile 
    210                 


<210>  6205
<211>  144
<212>  PRT
<213>  Homo Sapiens

<400>  6205

Met Ala Arg Gln Lys Lys Met Gly Gln Ser Val Leu Arg Ala Val Phe 
1               5                   10                  15      


Phe Leu Val Leu Gly Leu Leu Gly His Ser His Gly Gly Phe Pro Asn 
            20                  25                  30          


Thr Ile Ser Ile Gly Gly Leu Phe Met Arg Asn Thr Val Gln Glu His 
        35                  40                  45              


Ser Ala Phe Arg Phe Ala Val Gln Leu Tyr Asn Thr Asn Gln Asn Thr 
    50                  55                  60                  


Thr Glu Lys Pro Phe His Leu Asn Tyr His Val Asp His Leu Asp Ser 
65                  70                  75                  80  


Ser Asn Ser Phe Ser Val Thr Asn Ala Cys Pro Ala Glu Arg Asp Tyr 
                85                  90                  95      


Leu Pro Trp Pro Gly Ser Ile Arg Glu Asn Asn Trp Thr Ala Leu Pro 
            100                 105                 110         


Cys Cys Lys Asp His Gly Leu Leu His Leu Lys Cys Ser Pro Gly Gly 
        115                 120                 125             


Ala Arg Gln Asn Trp Ala Tyr Cys Ile Trp Gly Val Thr Gly Glu Leu 
    130                 135                 140                 


<210>  6206
<211>  144
<212>  PRT
<213>  Homo Sapiens

<400>  6206

Met Ala Arg Gln Lys Lys Met Gly Gln Ser Val Leu Arg Ala Val Phe 
1               5                   10                  15      


Phe Leu Val Leu Gly Leu Leu Gly His Ser His Gly Gly Phe Pro Asn 
            20                  25                  30          


Thr Ile Ser Ile Gly Gly Leu Phe Met Arg Asn Thr Val Gln Glu His 
        35                  40                  45              


Ser Ala Phe Arg Phe Ala Val Gln Leu Tyr Asn Thr Asn Gln Asn Thr 
    50                  55                  60                  


Thr Glu Lys Pro Phe His Leu Asn Tyr His Val Asp His Leu Asp Ser 
65                  70                  75                  80  


Ser Asn Ser Phe Ser Val Thr Asn Ala Cys Pro Ala Glu Arg Asp Tyr 
                85                  90                  95      


Leu Pro Trp Pro Gly Ser Ile Arg Glu Asn Asn Trp Thr Ala Leu Pro 
            100                 105                 110         


Cys Cys Lys Asp His Gly Leu Leu His Leu Lys Cys Ser Pro Gly Gly 
        115                 120                 125             


Ala Arg Gln Asn Trp Ala Tyr Cys Ile Trp Gly Val Thr Gly Glu Leu 
    130                 135                 140                 


<210>  6207
<211>  894
<212>  PRT
<213>  Homo Sapiens

<400>  6207

Met Ala Arg Gln Lys Lys Met Gly Gln Ser Val Leu Arg Ala Val Phe 
1               5                   10                  15      


Phe Leu Val Leu Gly Leu Leu Gly His Ser His Gly Gly Phe Pro Asn 
            20                  25                  30          


Thr Ile Ser Ile Gly Gly Leu Phe Met Arg Asn Thr Val Gln Glu His 
        35                  40                  45              


Ser Ala Phe Arg Phe Ala Val Gln Leu Tyr Asn Thr Asn Gln Asn Thr 
    50                  55                  60                  


Thr Glu Lys Pro Phe His Leu Asn Tyr His Val Asp His Leu Asp Ser 
65                  70                  75                  80  


Ser Asn Ser Phe Ser Val Thr Asn Ala Phe Cys Ser Gln Phe Ser Arg 
                85                  90                  95      


Gly Val Tyr Ala Ile Phe Gly Phe Tyr Asp Gln Met Ser Met Asn Thr 
            100                 105                 110         


Leu Thr Ser Phe Cys Gly Ala Leu His Thr Ser Phe Val Thr Pro Ser 
        115                 120                 125             


Phe Pro Thr Asp Ala Asp Val Gln Phe Val Ile Gln Met Arg Pro Ala 
    130                 135                 140                 


Leu Lys Gly Ala Ile Leu Ser Leu Leu Gly His Tyr Lys Trp Glu Lys 
145                 150                 155                 160 


Phe Val Tyr Leu Tyr Asp Thr Glu Arg Gly Phe Ser Ile Leu Gln Ala 
                165                 170                 175     


Ile Met Glu Ala Ala Val Gln Asn Asn Trp Gln Val Thr Ala Arg Ser 
            180                 185                 190         


Val Gly Asn Ile Lys Asp Val Gln Glu Phe Arg Arg Ile Ile Glu Glu 
        195                 200                 205             


Met Asp Arg Arg Gln Glu Lys Arg Tyr Leu Ile Asp Cys Glu Val Glu 
    210                 215                 220                 


Arg Ile Asn Thr Ile Leu Glu Gln Val Val Ile Leu Gly Lys His Ser 
225                 230                 235                 240 


Arg Gly Tyr His Tyr Met Leu Ala Asn Leu Gly Phe Thr Asp Ile Leu 
                245                 250                 255     


Leu Glu Arg Val Met His Gly Gly Ala Asn Ile Thr Gly Phe Gln Ile 
            260                 265                 270         


Val Asn Asn Glu Asn Pro Met Val Gln Gln Phe Ile Gln Arg Trp Val 
        275                 280                 285             


Arg Leu Asp Glu Arg Glu Phe Pro Glu Ala Lys Asn Ala Pro Leu Lys 
    290                 295                 300                 


Tyr Thr Ser Ala Leu Thr His Asp Ala Ile Leu Val Ile Ala Glu Ala 
305                 310                 315                 320 


Phe Arg Tyr Leu Arg Arg Gln Arg Val Asp Val Ser Arg Arg Gly Ser 
                325                 330                 335     


Ala Gly Asp Cys Leu Ala Asn Pro Ala Val Pro Trp Ser Gln Gly Ile 
            340                 345                 350         


Asp Ile Glu Arg Ala Leu Lys Met Val Gln Val Gln Gly Met Thr Gly 
        355                 360                 365             


Asn Ile Gln Phe Asp Thr Tyr Gly Arg Arg Thr Asn Tyr Thr Ile Asp 
    370                 375                 380                 


Val Tyr Glu Met Lys Val Ser Gly Ser Arg Lys Ala Gly Tyr Trp Asn 
385                 390                 395                 400 


Glu Tyr Glu Arg Phe Val Pro Phe Ser Asp Gln Gln Ile Ser Asn Asp 
                405                 410                 415     


Ser Ala Ser Ser Glu Asn Arg Thr Ile Val Val Thr Thr Ile Leu Glu 
            420                 425                 430         


Ser Pro Tyr Val Met Tyr Lys Lys Asn His Glu Gln Leu Glu Gly Asn 
        435                 440                 445             


Glu Arg Tyr Glu Gly Tyr Cys Val Asp Leu Ala Tyr Glu Ile Ala Lys 
    450                 455                 460                 


His Val Arg Ile Lys Tyr Lys Leu Ser Ile Val Gly Asp Gly Lys Tyr 
465                 470                 475                 480 


Gly Ala Arg Asp Pro Glu Thr Lys Ile Trp Asn Gly Met Val Gly Glu 
                485                 490                 495     


Leu Val Tyr Gly Arg Ala Asp Ile Ala Val Ala Pro Leu Thr Ile Thr 
            500                 505                 510         


Leu Val Arg Glu Glu Val Ile Asp Phe Ser Lys Pro Phe Met Ser Leu 
        515                 520                 525             


Gly Ile Ser Ile Met Ile Lys Lys Pro Gln Lys Ser Lys Pro Gly Val 
    530                 535                 540                 


Phe Ser Phe Leu Asp Pro Leu Ala Tyr Glu Ile Trp Met Cys Ile Val 
545                 550                 555                 560 


Phe Ala Tyr Ile Gly Val Ser Val Val Leu Phe Leu Val Ser Arg Phe 
                565                 570                 575     


Ser Pro Tyr Glu Trp His Leu Glu Asp Asn Asn Glu Glu Pro Arg Asp 
            580                 585                 590         


Pro Gln Ser Pro Pro Asp Pro Pro Asn Glu Phe Gly Ile Phe Asn Ser 
        595                 600                 605             


Leu Trp Phe Ser Leu Gly Ala Phe Met Gln Gln Gly Cys Asp Ile Ser 
    610                 615                 620                 


Pro Arg Ser Leu Ser Gly Arg Ile Val Gly Gly Val Trp Trp Phe Phe 
625                 630                 635                 640 


Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu 
                645                 650                 655     


Thr Val Glu Arg Met Val Ser Pro Ile Glu Ser Ala Glu Asp Leu Ala 
            660                 665                 670         


Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu Asp Ser Gly Ser Thr Lys 
        675                 680                 685             


Glu Phe Phe Arg Arg Ser Lys Ile Ala Val Tyr Glu Lys Met Trp Ser 
    690                 695                 700                 


Tyr Met Lys Ser Ala Glu Pro Ser Val Phe Thr Lys Thr Thr Ala Asp 
705                 710                 715                 720 


Gly Val Ala Arg Val Arg Lys Ser Lys Gly Lys Phe Ala Phe Leu Leu 
                725                 730                 735     


Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln Arg Lys Pro Cys Asp Thr 
            740                 745                 750         


Met Lys Val Gly Gly Asn Leu Asp Ser Lys Gly Tyr Gly Val Ala Thr 
        755                 760                 765             


Pro Lys Gly Ser Ala Leu Arg Thr Pro Val Asn Leu Ala Val Leu Lys 
    770                 775                 780                 


Leu Ser Glu Gln Gly Ile Leu Asp Lys Leu Lys Asn Lys Trp Trp Tyr 
785                 790                 795                 800 


Asp Lys Gly Glu Cys Gly Ala Lys Asp Ser Gly Ser Lys Asp Lys Thr 
                805                 810                 815     


Ser Ala Leu Ser Leu Ser Asn Val Ala Gly Val Phe Tyr Ile Leu Val 
            820                 825                 830         


Gly Gly Leu Gly Leu Ala Met Met Val Ala Leu Ile Glu Phe Cys Tyr 
        835                 840                 845             


Lys Ser Arg Ala Glu Ser Lys Arg Met Lys Leu Thr Lys Asn Thr Gln 
    850                 855                 860                 


Asn Phe Lys Pro Ala Pro Ala Thr Asn Thr Gln Asn Tyr Ala Thr Tyr 
865                 870                 875                 880 


Arg Glu Gly Tyr Asn Val Tyr Gly Thr Glu Ser Val Lys Ile 
                885                 890                 


<210>  6208
<211>  824
<212>  PRT
<213>  Homo Sapiens

<400>  6208

Met Ala Arg Gln Lys Lys Met Gly Gln Ser Val Leu Arg Ala Val Phe 
1               5                   10                  15      


Phe Leu Val Leu Gly Leu Leu Gly His Ser His Gly Gly Phe Pro Asn 
            20                  25                  30          


Thr Ile Ser Ile Gly Gly Leu Phe Met Arg Asn Thr Val Gln Glu His 
        35                  40                  45              


Ser Ala Phe Arg Phe Ala Val Gln Leu Tyr Asn Thr Asn Gln Asn Thr 
    50                  55                  60                  


Thr Glu Lys Pro Phe His Leu Asn Tyr His Val Asp His Leu Asp Ser 
65                  70                  75                  80  


Ser Asn Ser Phe Ser Val Thr Asn Ala Phe Cys Ser Gln Phe Ser Arg 
                85                  90                  95      


Gly Val Tyr Ala Ile Phe Gly Phe Tyr Asp Gln Met Ser Met Asn Thr 
            100                 105                 110         


Leu Thr Ser Phe Cys Gly Ala Leu His Thr Ser Phe Val Thr Pro Ser 
        115                 120                 125             


Phe Pro Thr Asp Ala Asp Val Gln Phe Val Ile Gln Met Arg Pro Ala 
    130                 135                 140                 


Leu Lys Gly Ala Ile Leu Ser Leu Leu Gly His Tyr Lys Trp Glu Lys 
145                 150                 155                 160 


Phe Val Tyr Leu Tyr Asp Thr Glu Arg Gly Phe Ser Ile Leu Gln Ala 
                165                 170                 175     


Ile Met Glu Ala Ala Val Gln Asn Asn Trp Gln Val Thr Ala Arg Ser 
            180                 185                 190         


Val Gly Asn Ile Lys Asp Val Gln Glu Phe Arg Arg Ile Ile Glu Glu 
        195                 200                 205             


Met Asp Arg Arg Gln Glu Lys Arg Tyr Leu Ile Asp Cys Glu Val Glu 
    210                 215                 220                 


Arg Ile Asn Thr Ile Leu Glu Gln Val Val Ile Leu Gly Lys His Ser 
225                 230                 235                 240 


Arg Gly Tyr His Tyr Met Leu Ala Asn Leu Gly Phe Thr Asp Ile Leu 
                245                 250                 255     


Leu Glu Arg Val Met His Gly Gly Ala Asn Ile Thr Gly Phe Gln Ile 
            260                 265                 270         


Val Asn Asn Glu Asn Pro Met Val Gln Gln Phe Ile Gln Arg Trp Val 
        275                 280                 285             


Arg Leu Asp Glu Arg Glu Phe Pro Glu Ala Lys Asn Ala Pro Leu Lys 
    290                 295                 300                 


Tyr Thr Ser Ala Leu Thr His Asp Ala Ile Leu Val Ile Ala Glu Ala 
305                 310                 315                 320 


Phe Arg Tyr Leu Arg Arg Gln Arg Val Asp Val Ser Arg Arg Gly Ser 
                325                 330                 335     


Ala Gly Asp Cys Leu Ala Asn Pro Ala Val Pro Trp Ser Gln Gly Ile 
            340                 345                 350         


Asp Ile Glu Arg Ala Leu Lys Met Val Gln Val Gln Gly Met Thr Gly 
        355                 360                 365             


Asn Ile Gln Phe Asp Thr Tyr Gly Arg Arg Thr Asn Tyr Thr Ile Asp 
    370                 375                 380                 


Val Tyr Glu Met Lys Val Ser Gly Ser Arg Lys Ala Gly Tyr Trp Asn 
385                 390                 395                 400 


Glu Tyr Glu Arg Phe Val Pro Phe Ser Asp Gln Gln Ile Ser Asn Asp 
                405                 410                 415     


Ser Ala Ser Ser Glu Asn Arg Thr Ile Val Val Thr Thr Ile Leu Glu 
            420                 425                 430         


Ser Pro Tyr Val Met Tyr Lys Lys Asn His Glu Gln Leu Glu Gly Asn 
        435                 440                 445             


Glu Arg Tyr Glu Gly Tyr Cys Val Asp Leu Ala Tyr Glu Ile Ala Lys 
    450                 455                 460                 


His Val Arg Ile Lys Tyr Lys Leu Ser Ile Val Gly Asp Gly Lys Tyr 
465                 470                 475                 480 


Gly Ala Arg Asp Pro Glu Thr Lys Ile Trp Asn Gly Met Val Gly Glu 
                485                 490                 495     


Leu Val Tyr Gly Arg Ala Asp Ile Ala Val Ala Pro Leu Thr Ile Thr 
            500                 505                 510         


Leu Val Arg Glu Glu Val Ile Asp Phe Ser Lys Pro Phe Met Ser Leu 
        515                 520                 525             


Gly Ile Ser Ile Met Ile Lys Lys Pro Gln Lys Ser Lys Pro Gly Val 
    530                 535                 540                 


Phe Ser Phe Leu Asp Pro Leu Ala Tyr Glu Ile Trp Met Cys Ile Val 
545                 550                 555                 560 


Phe Ala Tyr Ile Gly Val Ser Val Val Leu Phe Leu Val Ser Arg Phe 
                565                 570                 575     


Ser Pro Tyr Glu Trp His Leu Glu Asp Asn Asn Glu Glu Pro Arg Asp 
            580                 585                 590         


Pro Gln Ser Pro Pro Asp Pro Pro Asn Glu Phe Gly Ile Phe Asn Ser 
        595                 600                 605             


Leu Trp Phe Ser Leu Gly Ala Phe Met Gln Gln Gly Cys Asp Ile Ser 
    610                 615                 620                 


Pro Arg Ser Leu Ser Gly Arg Ile Val Gly Gly Val Trp Trp Phe Phe 
625                 630                 635                 640 


Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu 
                645                 650                 655     


Thr Val Glu Arg Met Val Ser Pro Ile Glu Ser Ala Glu Asp Leu Ala 
            660                 665                 670         


Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu Asp Ser Gly Ser Thr Lys 
        675                 680                 685             


Glu Phe Phe Arg Arg Ser Lys Ile Ala Val Tyr Glu Lys Met Trp Ser 
    690                 695                 700                 


Tyr Met Lys Ser Ala Glu Pro Ser Val Phe Thr Lys Thr Thr Ala Asp 
705                 710                 715                 720 


Gly Val Ala Arg Val Arg Lys Ser Lys Gly Lys Phe Ala Phe Leu Leu 
                725                 730                 735     


Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln Arg Lys Pro Cys Asp Thr 
            740                 745                 750         


Met Lys Val Gly Gly Asn Leu Asp Ser Lys Gly Tyr Gly Val Ala Thr 
        755                 760                 765             


Pro Lys Gly Ser Ala Leu Arg Asn Ala Val Asn Leu Ala Val Leu Lys 
    770                 775                 780                 


Leu Asn Glu Gln Gly Leu Leu Asp Lys Leu Lys Asn Lys Trp Trp Tyr 
785                 790                 795                 800 


Asp Lys Gly Glu Cys Gly Ser Gly Gly Gly Asp Ser Lys Asn Ala Cys 
                805                 810                 815     


Lys Pro Cys Ser Ile Glu Thr Gln 
            820                 


<210>  6209
<211>  894
<212>  PRT
<213>  Homo Sapiens

<400>  6209

Met Ala Arg Gln Lys Lys Met Gly Gln Ser Val Leu Arg Ala Val Phe 
1               5                   10                  15      


Phe Leu Val Leu Gly Leu Leu Gly His Ser His Gly Gly Phe Pro Asn 
            20                  25                  30          


Thr Ile Ser Ile Gly Gly Leu Phe Met Arg Asn Thr Val Gln Glu His 
        35                  40                  45              


Ser Ala Phe Arg Phe Ala Val Gln Leu Tyr Asn Thr Asn Gln Asn Thr 
    50                  55                  60                  


Thr Glu Lys Pro Phe His Leu Asn Tyr His Val Asp His Leu Asp Ser 
65                  70                  75                  80  


Ser Asn Ser Phe Ser Val Thr Asn Ala Phe Cys Ser Gln Phe Ser Arg 
                85                  90                  95      


Gly Val Tyr Ala Ile Phe Gly Phe Tyr Asp Gln Met Ser Met Asn Thr 
            100                 105                 110         


Leu Thr Ser Phe Cys Gly Ala Leu His Thr Ser Phe Val Thr Pro Ser 
        115                 120                 125             


Phe Pro Thr Asp Ala Asp Val Gln Phe Val Ile Gln Met Arg Pro Ala 
    130                 135                 140                 


Leu Lys Gly Ala Ile Leu Ser Leu Leu Gly His Tyr Lys Trp Glu Lys 
145                 150                 155                 160 


Phe Val Tyr Leu Tyr Asp Thr Glu Arg Gly Phe Ser Ile Leu Gln Ala 
                165                 170                 175     


Ile Met Glu Ala Ala Val Gln Asn Asn Trp Gln Val Thr Ala Arg Ser 
            180                 185                 190         


Val Gly Asn Ile Lys Asp Val Gln Glu Phe Arg Arg Ile Ile Glu Glu 
        195                 200                 205             


Met Asp Arg Arg Gln Glu Lys Arg Tyr Leu Ile Asp Cys Glu Val Glu 
    210                 215                 220                 


Arg Ile Asn Thr Ile Leu Glu Gln Val Val Ile Leu Gly Lys His Ser 
225                 230                 235                 240 


Arg Gly Tyr His Tyr Met Leu Ala Asn Leu Gly Phe Thr Asp Ile Leu 
                245                 250                 255     


Leu Glu Arg Val Met His Gly Gly Ala Asn Ile Thr Gly Phe Gln Ile 
            260                 265                 270         


Val Asn Asn Glu Asn Pro Met Val Gln Gln Phe Ile Gln Arg Trp Val 
        275                 280                 285             


Arg Leu Asp Glu Arg Glu Phe Pro Glu Ala Lys Asn Ala Pro Leu Lys 
    290                 295                 300                 


Tyr Thr Ser Ala Leu Thr His Asp Ala Ile Leu Val Ile Ala Glu Ala 
305                 310                 315                 320 


Phe Arg Tyr Leu Arg Arg Gln Arg Val Asp Val Ser Arg Arg Gly Ser 
                325                 330                 335     


Ala Gly Asp Cys Leu Ala Asn Pro Ala Val Pro Trp Ser Gln Gly Ile 
            340                 345                 350         


Asp Ile Glu Arg Ala Leu Lys Met Val Gln Val Gln Gly Met Thr Gly 
        355                 360                 365             


Asn Ile Gln Phe Asp Thr Tyr Gly Arg Arg Thr Asn Tyr Thr Ile Asp 
    370                 375                 380                 


Val Tyr Glu Met Lys Val Ser Gly Ser Arg Lys Ala Gly Tyr Trp Asn 
385                 390                 395                 400 


Glu Tyr Glu Arg Phe Val Pro Phe Ser Asp Gln Gln Ile Ser Asn Asp 
                405                 410                 415     


Ser Ala Ser Ser Glu Asn Arg Thr Ile Val Val Thr Thr Ile Leu Glu 
            420                 425                 430         


Ser Pro Tyr Val Met Tyr Lys Lys Asn His Glu Gln Leu Glu Gly Asn 
        435                 440                 445             


Glu Arg Tyr Glu Gly Tyr Cys Val Asp Leu Ala Tyr Glu Ile Ala Lys 
    450                 455                 460                 


His Val Arg Ile Lys Tyr Lys Leu Ser Ile Val Gly Asp Gly Lys Tyr 
465                 470                 475                 480 


Gly Ala Arg Asp Pro Glu Thr Lys Ile Trp Asn Gly Met Val Gly Glu 
                485                 490                 495     


Leu Val Tyr Gly Arg Ala Asp Ile Ala Val Ala Pro Leu Thr Ile Thr 
            500                 505                 510         


Leu Val Arg Glu Glu Val Ile Asp Phe Ser Lys Pro Phe Met Ser Leu 
        515                 520                 525             


Gly Ile Ser Ile Met Ile Lys Lys Pro Gln Lys Ser Lys Pro Gly Val 
    530                 535                 540                 


Phe Ser Phe Leu Asp Pro Leu Ala Tyr Glu Ile Trp Met Cys Ile Val 
545                 550                 555                 560 


Phe Ala Tyr Ile Gly Val Ser Val Val Leu Phe Leu Val Ser Arg Phe 
                565                 570                 575     


Ser Pro Tyr Glu Trp His Leu Glu Asp Asn Asn Glu Glu Pro Arg Asp 
            580                 585                 590         


Pro Gln Ser Pro Pro Asp Pro Pro Asn Glu Phe Gly Ile Phe Asn Ser 
        595                 600                 605             


Leu Trp Phe Ser Leu Gly Ala Phe Met Gln Gln Gly Cys Asp Ile Ser 
    610                 615                 620                 


Pro Arg Ser Leu Ser Gly Arg Ile Val Gly Gly Val Trp Trp Phe Phe 
625                 630                 635                 640 


Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu 
                645                 650                 655     


Thr Val Glu Arg Met Val Ser Pro Ile Glu Ser Ala Glu Asp Leu Ala 
            660                 665                 670         


Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu Asp Ser Gly Ser Thr Lys 
        675                 680                 685             


Glu Phe Phe Arg Arg Ser Lys Ile Ala Val Tyr Glu Lys Met Trp Ser 
    690                 695                 700                 


Tyr Met Lys Ser Ala Glu Pro Ser Val Phe Thr Lys Thr Thr Ala Asp 
705                 710                 715                 720 


Gly Val Ala Arg Val Arg Lys Ser Lys Gly Lys Phe Ala Phe Leu Leu 
                725                 730                 735     


Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln Arg Lys Pro Cys Asp Thr 
            740                 745                 750         


Met Lys Val Gly Gly Asn Leu Asp Ser Lys Gly Tyr Gly Val Ala Thr 
        755                 760                 765             


Pro Lys Gly Ser Ala Leu Arg Asn Ala Val Asn Leu Ala Val Leu Lys 
    770                 775                 780                 


Leu Asn Glu Gln Gly Leu Leu Asp Lys Leu Lys Asn Lys Trp Trp Tyr 
785                 790                 795                 800 


Asp Lys Gly Glu Cys Gly Ser Gly Gly Gly Asp Ser Lys Asp Lys Thr 
                805                 810                 815     


Ser Ala Leu Ser Leu Ser Asn Val Ala Gly Val Phe Tyr Ile Leu Val 
            820                 825                 830         


Gly Gly Leu Gly Leu Ala Met Met Val Ala Leu Ile Glu Phe Cys Tyr 
        835                 840                 845             


Lys Ser Arg Ala Glu Ser Lys Arg Met Lys Leu Thr Lys Asn Thr Gln 
    850                 855                 860                 


Asn Phe Lys Pro Ala Pro Ala Thr Asn Thr Gln Asn Tyr Ala Thr Tyr 
865                 870                 875                 880 


Arg Glu Gly Tyr Asn Val Tyr Gly Thr Glu Ser Val Lys Ile 
                885                 890                 


<210>  6210
<211>  894
<212>  PRT
<213>  Homo Sapiens

<400>  6210

Met Ala Arg Gln Lys Lys Met Gly Gln Ser Val Leu Arg Ala Val Phe 
1               5                   10                  15      


Phe Leu Val Leu Gly Leu Leu Gly His Ser His Gly Gly Phe Pro Asn 
            20                  25                  30          


Thr Ile Ser Ile Gly Gly Leu Phe Met Arg Asn Thr Val Gln Glu His 
        35                  40                  45              


Ser Ala Phe Arg Phe Ala Val Gln Leu Tyr Asn Thr Asn Gln Asn Thr 
    50                  55                  60                  


Thr Glu Lys Pro Phe His Leu Asn Tyr His Val Asp His Leu Asp Ser 
65                  70                  75                  80  


Ser Asn Ser Phe Ser Val Thr Asn Ala Phe Cys Ser Gln Phe Ser Arg 
                85                  90                  95      


Gly Val Tyr Ala Ile Phe Gly Phe Tyr Asp Gln Met Ser Met Asn Thr 
            100                 105                 110         


Leu Thr Ser Phe Cys Gly Ala Leu His Thr Ser Phe Val Thr Pro Ser 
        115                 120                 125             


Phe Pro Thr Asp Ala Asp Val Gln Phe Val Ile Gln Met Arg Pro Ala 
    130                 135                 140                 


Leu Lys Gly Ala Ile Leu Ser Leu Leu Gly His Tyr Lys Trp Glu Lys 
145                 150                 155                 160 


Phe Val Tyr Leu Tyr Asp Thr Glu Arg Gly Phe Ser Ile Leu Gln Ala 
                165                 170                 175     


Ile Met Glu Ala Ala Val Gln Asn Asn Trp Gln Val Thr Ala Arg Ser 
            180                 185                 190         


Val Gly Asn Ile Lys Asp Val Gln Glu Phe Arg Arg Ile Ile Glu Glu 
        195                 200                 205             


Met Asp Arg Arg Gln Glu Lys Arg Tyr Leu Ile Asp Cys Glu Val Glu 
    210                 215                 220                 


Arg Ile Asn Thr Ile Leu Glu Gln Val Val Ile Leu Gly Lys His Ser 
225                 230                 235                 240 


Arg Gly Tyr His Tyr Met Leu Ala Asn Leu Gly Phe Thr Asp Ile Leu 
                245                 250                 255     


Leu Glu Arg Val Met His Gly Gly Ala Asn Ile Thr Gly Phe Gln Ile 
            260                 265                 270         


Val Asn Asn Glu Asn Pro Met Val Gln Gln Phe Ile Gln Arg Trp Val 
        275                 280                 285             


Arg Leu Asp Glu Arg Glu Phe Pro Glu Ala Lys Asn Ala Pro Leu Lys 
    290                 295                 300                 


Tyr Thr Ser Ala Leu Thr His Asp Ala Ile Leu Val Ile Ala Glu Ala 
305                 310                 315                 320 


Phe Arg Tyr Leu Arg Arg Gln Arg Val Asp Val Ser Arg Arg Gly Ser 
                325                 330                 335     


Ala Gly Asp Cys Leu Ala Asn Pro Ala Val Pro Trp Ser Gln Gly Ile 
            340                 345                 350         


Asp Ile Glu Arg Ala Leu Lys Met Val Gln Val Gln Gly Met Thr Gly 
        355                 360                 365             


Asn Ile Gln Phe Asp Thr Tyr Gly Arg Arg Thr Asn Tyr Thr Ile Asp 
    370                 375                 380                 


Val Tyr Glu Met Lys Val Ser Gly Ser Arg Lys Ala Gly Tyr Trp Asn 
385                 390                 395                 400 


Glu Tyr Glu Arg Phe Val Pro Phe Ser Asp Gln Gln Ile Ser Asn Asp 
                405                 410                 415     


Ser Ala Ser Ser Glu Asn Arg Thr Ile Val Val Thr Thr Ile Leu Glu 
            420                 425                 430         


Ser Pro Tyr Val Met Tyr Lys Lys Asn His Glu Gln Leu Glu Gly Asn 
        435                 440                 445             


Glu Arg Tyr Glu Gly Tyr Cys Val Asp Leu Ala Tyr Glu Ile Ala Lys 
    450                 455                 460                 


His Val Arg Ile Lys Tyr Lys Leu Ser Ile Val Gly Asp Gly Lys Tyr 
465                 470                 475                 480 


Gly Ala Arg Asp Pro Glu Thr Lys Ile Trp Asn Gly Met Val Gly Glu 
                485                 490                 495     


Leu Val Tyr Gly Arg Ala Asp Ile Ala Val Ala Pro Leu Thr Ile Thr 
            500                 505                 510         


Leu Val Arg Glu Glu Val Ile Asp Phe Ser Lys Pro Phe Met Ser Leu 
        515                 520                 525             


Gly Ile Ser Ile Met Ile Lys Lys Pro Gln Lys Ser Lys Pro Gly Val 
    530                 535                 540                 


Phe Ser Phe Leu Asp Pro Leu Ala Tyr Glu Ile Trp Met Cys Ile Val 
545                 550                 555                 560 


Phe Ala Tyr Ile Gly Val Ser Val Val Leu Phe Leu Val Ser Arg Phe 
                565                 570                 575     


Ser Pro Tyr Glu Trp His Leu Glu Asp Asn Asn Glu Glu Pro Arg Asp 
            580                 585                 590         


Pro Gln Ser Pro Pro Asp Pro Pro Asn Glu Phe Gly Ile Phe Asn Ser 
        595                 600                 605             


Leu Trp Phe Ser Leu Gly Ala Phe Met Gln Gln Gly Cys Asp Ile Ser 
    610                 615                 620                 


Pro Arg Ser Leu Ser Gly Arg Ile Val Gly Gly Val Trp Trp Phe Phe 
625                 630                 635                 640 


Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu 
                645                 650                 655     


Thr Val Glu Arg Met Val Ser Pro Ile Glu Ser Ala Glu Asp Leu Ala 
            660                 665                 670         


Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu Asp Ser Gly Ser Thr Lys 
        675                 680                 685             


Glu Phe Phe Arg Arg Ser Lys Ile Ala Val Tyr Glu Lys Met Trp Ser 
    690                 695                 700                 


Tyr Met Lys Ser Ala Glu Pro Ser Val Phe Thr Lys Thr Thr Ala Asp 
705                 710                 715                 720 


Gly Val Ala Arg Val Arg Lys Ser Lys Gly Lys Phe Ala Phe Leu Leu 
                725                 730                 735     


Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln Arg Lys Pro Cys Asp Thr 
            740                 745                 750         


Met Lys Val Gly Gly Asn Leu Asp Ser Lys Gly Tyr Gly Val Ala Thr 
        755                 760                 765             


Pro Lys Gly Ser Ala Leu Arg Asn Ala Val Asn Leu Ala Val Leu Lys 
    770                 775                 780                 


Leu Asn Glu Gln Gly Leu Leu Asp Lys Leu Lys Asn Lys Trp Trp Tyr 
785                 790                 795                 800 


Asp Lys Gly Glu Cys Gly Ser Gly Gly Gly Asp Ser Lys Asp Lys Thr 
                805                 810                 815     


Ser Ala Leu Ser Leu Ser Asn Val Ala Gly Val Phe Tyr Ile Leu Val 
            820                 825                 830         


Gly Gly Leu Gly Leu Ala Met Met Val Ala Leu Ile Glu Phe Cys Tyr 
        835                 840                 845             


Lys Ser Arg Ala Glu Ser Lys Arg Met Lys Leu Thr Lys Asn Thr Gln 
    850                 855                 860                 


Asn Phe Lys Pro Ala Pro Ala Thr Asn Thr Gln Asn Tyr Ala Thr Tyr 
865                 870                 875                 880 


Arg Glu Gly Tyr Asn Val Tyr Gly Thr Glu Ser Val Lys Ile 
                885                 890                 


<210>  6211
<211>  82
<212>  PRT
<213>  Homo Sapiens

<400>  6211

Met Arg Ile Ile Ser Arg Gln Ile Val Leu Leu Phe Ser Gly Phe Trp 
1               5                   10                  15      


Gly Leu Ala Met Gly Ala Phe Pro Ser Ser Val Gln Ile Gly Gly Leu 
            20                  25                  30          


Phe Ile Arg Asn Thr Asp Gln Glu Tyr Thr Ala Phe Arg Leu Ala Ile 
        35                  40                  45              


Phe Leu His Asn Thr Ser Pro Asn Ala Ser Glu Ala Pro Phe Asn Leu 
    50                  55                  60                  


Val Pro His Val Asp Asn Ile Glu Thr Ala Asn Ser Phe Ala Val Thr 
65                  70                  75                  80  


Asn Ala 
        


<210>  6212
<211>  82
<212>  PRT
<213>  Homo Sapiens

<400>  6212

Met Arg Ile Ile Ser Arg Gln Ile Val Leu Leu Phe Ser Gly Phe Trp 
1               5                   10                  15      


Gly Leu Ala Met Gly Ala Phe Pro Ser Ser Val Gln Ile Gly Gly Leu 
            20                  25                  30          


Phe Ile Arg Asn Thr Asp Gln Glu Tyr Thr Ala Phe Arg Leu Ala Ile 
        35                  40                  45              


Phe Leu His Asn Thr Ser Pro Asn Ala Ser Glu Ala Pro Phe Asn Leu 
    50                  55                  60                  


Val Pro His Val Asp Asn Ile Glu Thr Ala Asn Ser Phe Ala Val Thr 
65                  70                  75                  80  


Asn Ala 
        


<210>  6213
<211>  82
<212>  PRT
<213>  Homo Sapiens

<400>  6213

Met Arg Ile Ile Ser Arg Gln Ile Val Leu Leu Phe Ser Gly Phe Trp 
1               5                   10                  15      


Gly Leu Ala Met Gly Ala Phe Pro Ser Ser Val Gln Ile Gly Gly Leu 
            20                  25                  30          


Phe Ile Arg Asn Thr Asp Gln Glu Tyr Thr Ala Phe Arg Leu Ala Ile 
        35                  40                  45              


Phe Leu His Asn Thr Ser Pro Asn Ala Ser Glu Ala Pro Phe Asn Leu 
    50                  55                  60                  


Val Pro His Val Asp Asn Ile Glu Thr Ala Asn Ser Phe Ala Val Thr 
65                  70                  75                  80  


Asn Ala 
        


<210>  6214
<211>  84
<212>  PRT
<213>  Homo Sapiens

<400>  6214

Met Arg Ile Ile Ser Arg Gln Ile Val Leu Leu Phe Ser Gly Phe Trp 
1               5                   10                  15      


Gly Leu Ala Met Gly Ala Phe Pro Ser Ser Val Gln Ile Gly Gly Leu 
            20                  25                  30          


Phe Ile Arg Asn Thr Asp Gln Glu Tyr Thr Ala Phe Arg Leu Ala Ile 
        35                  40                  45              


Phe Leu His Asn Thr Ser Pro Asn Ala Ser Glu Ala Pro Phe Asn Leu 
    50                  55                  60                  


Val Pro His Val Asp Asn Ile Glu Thr Ala Asn Ser Phe Ala Val Thr 
65                  70                  75                  80  


Asn Ala Cys Lys 
                


<210>  6215
<211>  225
<212>  PRT
<213>  Homo Sapiens

<400>  6215

Met Arg Ile Ile Ser Arg Gln Ile Val Leu Leu Phe Ser Gly Phe Trp 
1               5                   10                  15      


Gly Leu Ala Met Gly Ala Phe Pro Ser Ser Val Gln Ile Gly Gly Leu 
            20                  25                  30          


Phe Ile Arg Asn Thr Asp Gln Glu Tyr Thr Ala Phe Arg Leu Ala Ile 
        35                  40                  45              


Phe Leu His Asn Thr Ser Pro Asn Ala Ser Glu Ala Pro Phe Asn Leu 
    50                  55                  60                  


Val Pro His Val Asp Asn Ile Glu Thr Ala Asn Ser Phe Ala Val Thr 
65                  70                  75                  80  


Asn Ala Phe Cys Ser Gln Tyr Ser Arg Gly Val Phe Ala Ile Phe Gly 
                85                  90                  95      


Leu Tyr Asp Lys Arg Ser Val His Thr Leu Thr Ser Phe Cys Ser Ala 
            100                 105                 110         


Leu His Ile Ser Leu Ile Thr Pro Ser Phe Pro Thr Glu Gly Glu Ser 
        115                 120                 125             


Gln Phe Val Leu Gln Leu Arg Pro Ser Leu Arg Gly Ala Leu Leu Ser 
    130                 135                 140                 


Leu Leu Asp His Tyr Glu Trp Asn Cys Phe Val Phe Leu Tyr Asp Thr 
145                 150                 155                 160 


Asp Arg Gly Leu Val Ile Ser Thr Thr Pro Leu Ala Ser Asn Cys Met 
                165                 170                 175     


Pro Ser Ser Val Val His Ser Trp Leu Tyr Val Leu Tyr Asn Lys Ser 
            180                 185                 190         


Ile Asn Ser Ile Thr Ala Cys Leu Leu Gly Pro Ser Thr Glu Leu Asn 
        195                 200                 205             


Val Phe Asn Tyr Leu Ile Ala Asp Ser Asn Leu Asn Asn Gly Asn Tyr 
    210                 215                 220                 


Ile 
225 


<210>  6216
<211>  902
<212>  PRT
<213>  Homo Sapiens

<400>  6216

Met Arg Ile Ile Ser Arg Gln Ile Val Leu Leu Phe Ser Gly Phe Trp 
1               5                   10                  15      


Gly Leu Ala Met Gly Ala Phe Pro Ser Ser Val Gln Ile Gly Gly Leu 
            20                  25                  30          


Phe Ile Arg Asn Thr Asp Gln Glu Tyr Thr Ala Phe Arg Leu Ala Ile 
        35                  40                  45              


Phe Leu His Asn Thr Ser Pro Asn Ala Ser Glu Ala Pro Phe Asn Leu 
    50                  55                  60                  


Val Pro His Val Asp Asn Ile Glu Thr Ala Asn Ser Phe Ala Val Thr 
65                  70                  75                  80  


Asn Ala Phe Cys Ser Gln Tyr Ser Arg Gly Val Phe Ala Ile Phe Gly 
                85                  90                  95      


Leu Tyr Asp Lys Arg Ser Val His Thr Leu Thr Ser Phe Cys Ser Ala 
            100                 105                 110         


Leu His Ile Ser Leu Ile Thr Pro Ser Phe Pro Thr Glu Gly Glu Ser 
        115                 120                 125             


Gln Phe Val Leu Gln Leu Arg Pro Ser Leu Arg Gly Ala Leu Leu Ser 
    130                 135                 140                 


Leu Leu Asp His Tyr Glu Trp Asn Cys Phe Val Phe Leu Tyr Asp Thr 
145                 150                 155                 160 


Asp Arg Gly Tyr Ser Ile Leu Gln Ala Ile Met Glu Lys Ala Gly Gln 
                165                 170                 175     


Asn Gly Trp His Val Ser Ala Ile Cys Val Glu Asn Phe Asn Asp Val 
            180                 185                 190         


Ser Tyr Arg Gln Leu Leu Glu Glu Leu Asp Arg Arg Gln Glu Lys Lys 
        195                 200                 205             


Phe Val Ile Asp Cys Glu Ile Glu Arg Leu Gln Asn Ile Leu Glu Gln 
    210                 215                 220                 


Ile Val Ser Val Gly Lys His Val Lys Gly Tyr His Tyr Ile Ile Ala 
225                 230                 235                 240 


Asn Leu Gly Phe Lys Asp Ile Ser Leu Glu Arg Phe Ile His Gly Gly 
                245                 250                 255     


Ala Asn Val Thr Gly Phe Gln Leu Val Asp Phe Asn Thr Pro Met Val 
            260                 265                 270         


Ile Lys Leu Met Asp Arg Trp Lys Lys Leu Asp Gln Arg Glu Tyr Pro 
        275                 280                 285             


Gly Ser Glu Thr Pro Pro Lys Tyr Thr Ser Ala Leu Thr Tyr Asp Gly 
    290                 295                 300                 


Val Leu Val Met Ala Glu Thr Phe Arg Ser Leu Arg Arg Gln Lys Ile 
305                 310                 315                 320 


Asp Ile Ser Arg Arg Gly Asn Ala Gly Asp Cys Leu Ala Asn Pro Ala 
                325                 330                 335     


Ala Pro Trp Gly Gln Gly Ile Asp Met Glu Arg Thr Leu Lys Gln Val 
            340                 345                 350         


Arg Ile Gln Gly Leu Thr Gly Asn Val Gln Phe Asp His Tyr Gly Arg 
        355                 360                 365             


Arg Val Asn Tyr Thr Met Asp Val Phe Glu Leu Lys Ser Thr Gly Pro 
    370                 375                 380                 


Arg Lys Val Gly Tyr Trp Asn Asp Met Asp Lys Leu Val Leu Ile Gln 
385                 390                 395                 400 


Asp Val Pro Thr Leu Gly Asn Asp Thr Ala Ala Ile Glu Asn Arg Thr 
                405                 410                 415     


Val Val Val Thr Thr Ile Met Glu Ser Pro Tyr Val Met Tyr Lys Lys 
            420                 425                 430         


Asn His Glu Met Phe Glu Gly Asn Asp Lys Tyr Glu Gly Tyr Cys Val 
        435                 440                 445             


Asp Leu Ala Ser Glu Ile Ala Lys His Ile Gly Ile Lys Tyr Lys Ile 
    450                 455                 460                 


Ala Ile Val Pro Asp Gly Lys Tyr Gly Ala Arg Asp Ala Asp Thr Lys 
465                 470                 475                 480 


Ile Trp Asn Gly Met Val Gly Glu Leu Val Tyr Gly Lys Ala Glu Ile 
                485                 490                 495     


Ala Ile Ala Pro Leu Thr Ile Thr Leu Val Arg Glu Glu Val Ile Asp 
            500                 505                 510         


Phe Ser Lys Pro Phe Met Ser Leu Gly Ile Ser Ile Met Ile Lys Lys 
        515                 520                 525             


Pro Gln Lys Ser Lys Pro Gly Val Phe Ser Phe Leu Asp Pro Leu Ala 
    530                 535                 540                 


Tyr Glu Ile Trp Met Cys Ile Val Phe Ala Tyr Ile Gly Val Ser Val 
545                 550                 555                 560 


Val Leu Phe Leu Val Ser Arg Phe Ser Pro Tyr Glu Trp His Thr Glu 
                565                 570                 575     


Glu Pro Glu Asp Gly Lys Glu Gly Pro Ser Asp Gln Pro Pro Asn Glu 
            580                 585                 590         


Phe Gly Ile Phe Asn Ser Leu Trp Phe Ser Leu Gly Ala Phe Met Gln 
        595                 600                 605             


Gln Gly Cys Asp Ile Ser Pro Arg Ser Leu Ser Gly Arg Ile Val Gly 
    610                 615                 620                 


Gly Val Trp Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala 
625                 630                 635                 640 


Asn Leu Ala Ala Phe Leu Thr Val Glu Arg Met Val Ser Pro Ile Glu 
                645                 650                 655     


Ser Ala Glu Asp Leu Ala Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu 
            660                 665                 670         


Asp Ser Gly Ser Thr Lys Glu Phe Phe Arg Arg Ser Lys Ile Ala Val 
        675                 680                 685             


Tyr Glu Lys Met Trp Thr Tyr Met Arg Ser Ala Glu Pro Ser Val Phe 
    690                 695                 700                 


Thr Arg Thr Thr Ala Glu Gly Val Ala Arg Val Arg Lys Ser Lys Gly 
705                 710                 715                 720 


Lys Phe Ala Phe Leu Leu Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln 
                725                 730                 735     


Arg Lys Pro Cys Asp Thr Met Lys Val Gly Gly Asn Leu Asp Ser Lys 
            740                 745                 750         


Gly Tyr Gly Val Ala Thr Pro Lys Gly Ser Ser Leu Arg Thr Pro Val 
        755                 760                 765             


Asn Leu Ala Val Leu Lys Leu Ser Glu Ala Gly Val Leu Asp Lys Leu 
    770                 775                 780                 


Lys Asn Lys Trp Trp Tyr Asp Lys Gly Glu Cys Gly Pro Lys Asp Ser 
785                 790                 795                 800 


Gly Ser Lys Asp Lys Thr Ser Ala Leu Ser Leu Ser Asn Val Ala Gly 
                805                 810                 815     


Val Phe Tyr Ile Leu Val Gly Gly Leu Gly Leu Ala Met Leu Val Ala 
            820                 825                 830         


Leu Ile Glu Phe Cys Tyr Lys Ser Arg Ala Glu Ala Lys Arg Met Lys 
        835                 840                 845             


Leu Thr Phe Ser Glu Ala Ile Arg Asn Lys Ala Arg Leu Ser Ile Thr 
    850                 855                 860                 


Gly Ser Val Gly Glu Asn Gly Arg Val Leu Thr Pro Asp Cys Pro Lys 
865                 870                 875                 880 


Ala Val His Thr Gly Thr Ala Ile Arg Gln Ser Ser Gly Leu Ala Val 
                885                 890                 895     


Ile Ala Ser Asp Leu Pro 
            900         


<210>  6217
<211>  433
<212>  PRT
<213>  Homo Sapiens

<400>  6217

Met Arg Ile Ile Ser Arg Gln Ile Val Leu Leu Phe Ser Gly Phe Trp 
1               5                   10                  15      


Gly Leu Ala Met Gly Ala Phe Pro Ser Ser Val Gln Ile Gly Gly Leu 
            20                  25                  30          


Phe Ile Arg Asn Thr Asp Gln Glu Tyr Thr Ala Phe Arg Leu Ala Ile 
        35                  40                  45              


Phe Leu His Asn Thr Ser Pro Asn Ala Ser Glu Ala Pro Phe Asn Leu 
    50                  55                  60                  


Val Pro His Val Asp Asn Ile Glu Thr Ala Asn Ser Phe Ala Val Thr 
65                  70                  75                  80  


Asn Ala Phe Cys Ser Gln Tyr Ser Arg Gly Val Phe Ala Ile Phe Gly 
                85                  90                  95      


Leu Tyr Asp Lys Arg Ser Val His Thr Leu Thr Ser Phe Cys Ser Ala 
            100                 105                 110         


Leu His Ile Ser Leu Ile Thr Pro Ser Phe Pro Thr Glu Gly Glu Ser 
        115                 120                 125             


Gln Phe Val Leu Gln Leu Arg Pro Ser Leu Arg Gly Ala Leu Leu Ser 
    130                 135                 140                 


Leu Leu Asp His Tyr Glu Trp Asn Cys Phe Val Phe Leu Tyr Asp Thr 
145                 150                 155                 160 


Asp Arg Gly Tyr Ser Ile Leu Gln Ala Ile Met Glu Lys Ala Gly Gln 
                165                 170                 175     


Asn Gly Trp His Val Ser Ala Ile Cys Val Glu Asn Phe Asn Asp Val 
            180                 185                 190         


Ser Tyr Arg Gln Leu Leu Glu Glu Leu Asp Arg Arg Gln Glu Lys Lys 
        195                 200                 205             


Phe Val Ile Asp Cys Glu Ile Glu Arg Leu Gln Asn Ile Leu Glu Gln 
    210                 215                 220                 


Ile Val Ser Val Gly Lys His Val Lys Gly Tyr His Tyr Ile Ile Ala 
225                 230                 235                 240 


Asn Leu Gly Phe Lys Asp Ile Ser Leu Glu Arg Phe Ile His Gly Gly 
                245                 250                 255     


Ala Asn Val Thr Gly Phe Gln Leu Val Asp Phe Asn Thr Pro Met Val 
            260                 265                 270         


Ile Lys Leu Met Asp Arg Trp Lys Lys Leu Asp Gln Arg Glu Tyr Pro 
        275                 280                 285             


Gly Ser Glu Thr Pro Pro Lys Tyr Thr Ser Ala Leu Thr Tyr Asp Gly 
    290                 295                 300                 


Val Leu Val Met Ala Glu Thr Phe Arg Ser Leu Arg Arg Gln Lys Ile 
305                 310                 315                 320 


Asp Ile Ser Arg Arg Gly Asn Ala Gly Asp Cys Leu Ala Asn Pro Ala 
                325                 330                 335     


Ala Pro Trp Gly Gln Gly Ile Asp Met Glu Arg Thr Leu Lys Gln Val 
            340                 345                 350         


Arg Ile Gln Gly Leu Thr Gly Asn Val Gln Phe Asp His Tyr Gly Arg 
        355                 360                 365             


Arg Val Asn Tyr Thr Met Asp Val Phe Glu Leu Lys Ser Thr Gly Pro 
    370                 375                 380                 


Arg Lys Val Gly Tyr Trp Asn Asp Met Asp Lys Leu Val Leu Ile Gln 
385                 390                 395                 400 


Asp Val Pro Thr Leu Gly Asn Asp Thr Ala Ala Ile Glu Asn Arg Thr 
                405                 410                 415     


Val Val Val Thr Thr Ile Met Pro Leu Met Lys Asn Pro Ile Leu Arg 
            420                 425                 430         


Asn 
    


<210>  6218
<211>  884
<212>  PRT
<213>  Homo Sapiens

<400>  6218

Met Arg Ile Ile Ser Arg Gln Ile Val Leu Leu Phe Ser Gly Phe Trp 
1               5                   10                  15      


Gly Leu Ala Met Gly Ala Phe Pro Ser Ser Val Gln Ile Gly Gly Leu 
            20                  25                  30          


Phe Ile Arg Asn Thr Asp Gln Glu Tyr Thr Ala Phe Arg Leu Ala Ile 
        35                  40                  45              


Phe Leu His Asn Thr Ser Pro Asn Ala Ser Glu Ala Pro Phe Asn Leu 
    50                  55                  60                  


Val Pro His Val Asp Asn Ile Glu Thr Ala Asn Ser Phe Ala Val Thr 
65                  70                  75                  80  


Asn Ala Phe Cys Ser Gln Tyr Ser Arg Gly Val Phe Ala Ile Phe Gly 
                85                  90                  95      


Leu Tyr Asp Lys Arg Ser Val His Thr Leu Thr Ser Phe Cys Ser Ala 
            100                 105                 110         


Leu His Ile Ser Leu Ile Thr Pro Ser Phe Pro Thr Glu Gly Glu Ser 
        115                 120                 125             


Gln Phe Val Leu Gln Leu Arg Pro Ser Leu Arg Gly Ala Leu Leu Ser 
    130                 135                 140                 


Leu Leu Asp His Tyr Glu Trp Asn Cys Phe Val Phe Leu Tyr Asp Thr 
145                 150                 155                 160 


Asp Arg Gly Tyr Ser Ile Leu Gln Ala Ile Met Glu Lys Ala Gly Gln 
                165                 170                 175     


Asn Gly Trp His Val Ser Ala Ile Cys Val Glu Asn Phe Asn Asp Val 
            180                 185                 190         


Ser Tyr Arg Gln Leu Leu Glu Glu Leu Asp Arg Arg Gln Glu Lys Lys 
        195                 200                 205             


Phe Val Ile Asp Cys Glu Ile Glu Arg Leu Gln Asn Ile Leu Glu Gln 
    210                 215                 220                 


Ile Val Ser Val Gly Lys His Val Lys Gly Tyr His Tyr Ile Ile Ala 
225                 230                 235                 240 


Asn Leu Gly Phe Lys Asp Ile Ser Leu Glu Arg Phe Ile His Gly Gly 
                245                 250                 255     


Ala Asn Val Thr Gly Phe Gln Leu Val Asp Phe Asn Thr Pro Met Val 
            260                 265                 270         


Ile Lys Leu Met Asp Arg Trp Lys Lys Leu Asp Gln Arg Glu Tyr Pro 
        275                 280                 285             


Gly Ser Glu Thr Pro Pro Lys Tyr Thr Ser Ala Leu Thr Tyr Asp Gly 
    290                 295                 300                 


Val Leu Val Met Ala Glu Thr Phe Arg Ser Leu Arg Arg Gln Lys Ile 
305                 310                 315                 320 


Asp Ile Ser Arg Arg Gly Asn Ala Gly Asp Cys Leu Ala Asn Pro Ala 
                325                 330                 335     


Ala Pro Trp Gly Gln Gly Ile Asp Met Glu Arg Thr Leu Lys Gln Val 
            340                 345                 350         


Arg Ile Gln Gly Leu Thr Gly Asn Val Gln Phe Asp His Tyr Gly Arg 
        355                 360                 365             


Arg Val Asn Tyr Thr Met Asp Val Phe Glu Leu Lys Ser Thr Gly Pro 
    370                 375                 380                 


Arg Lys Val Gly Tyr Trp Asn Asp Met Asp Lys Leu Val Leu Ile Gln 
385                 390                 395                 400 


Asp Val Pro Thr Leu Gly Asn Asp Thr Ala Ala Ile Glu Asn Arg Thr 
                405                 410                 415     


Val Val Val Thr Thr Ile Met Glu Ser Pro Tyr Val Met Tyr Lys Lys 
            420                 425                 430         


Asn His Glu Met Phe Glu Gly Asn Asp Lys Tyr Glu Gly Tyr Cys Val 
        435                 440                 445             


Asp Leu Ala Ser Glu Ile Ala Lys His Ile Gly Ile Lys Tyr Lys Ile 
    450                 455                 460                 


Ala Ile Val Pro Asp Gly Lys Tyr Gly Ala Arg Asp Ala Asp Thr Lys 
465                 470                 475                 480 


Ile Trp Asn Gly Met Val Gly Glu Leu Val Tyr Gly Lys Ala Glu Ile 
                485                 490                 495     


Ala Ile Ala Pro Leu Thr Ile Thr Leu Val Arg Glu Glu Val Ile Asp 
            500                 505                 510         


Phe Ser Lys Pro Phe Met Ser Leu Gly Ile Ser Ile Met Ile Lys Lys 
        515                 520                 525             


Pro Gln Lys Ser Lys Pro Gly Val Phe Ser Phe Leu Asp Pro Leu Ala 
    530                 535                 540                 


Tyr Glu Ile Trp Met Cys Ile Val Phe Ala Tyr Ile Gly Val Ser Val 
545                 550                 555                 560 


Val Leu Phe Leu Val Ser Arg Phe Ser Pro Tyr Glu Trp His Thr Glu 
                565                 570                 575     


Glu Pro Glu Asp Gly Lys Glu Gly Pro Ser Asp Gln Pro Pro Asn Glu 
            580                 585                 590         


Phe Gly Ile Phe Asn Ser Leu Trp Phe Ser Leu Gly Ala Phe Met Gln 
        595                 600                 605             


Gln Gly Cys Asp Ile Ser Pro Arg Ser Leu Ser Gly Arg Ile Val Gly 
    610                 615                 620                 


Gly Val Trp Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala 
625                 630                 635                 640 


Asn Leu Ala Ala Phe Leu Thr Val Glu Arg Met Val Ser Pro Ile Glu 
                645                 650                 655     


Ser Ala Glu Asp Leu Ala Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu 
            660                 665                 670         


Asp Ser Gly Ser Thr Lys Glu Phe Phe Arg Arg Ser Lys Ile Ala Val 
        675                 680                 685             


Tyr Glu Lys Met Trp Thr Tyr Met Arg Ser Ala Glu Pro Ser Val Phe 
    690                 695                 700                 


Thr Arg Thr Thr Ala Glu Gly Val Ala Arg Val Arg Lys Ser Lys Gly 
705                 710                 715                 720 


Lys Phe Ala Phe Leu Leu Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln 
                725                 730                 735     


Arg Lys Pro Cys Asp Thr Met Lys Val Gly Gly Asn Leu Asp Ser Lys 
            740                 745                 750         


Gly Tyr Gly Val Ala Thr Pro Lys Gly Ser Ser Leu Arg Asn Ala Val 
        755                 760                 765             


Asn Leu Ala Val Leu Lys Leu Asn Glu Gln Gly Leu Leu Asp Lys Leu 
    770                 775                 780                 


Lys Asn Lys Trp Trp Tyr Asp Lys Gly Glu Cys Gly Ser Gly Gly Gly 
785                 790                 795                 800 


Asp Ser Lys Asp Lys Thr Ser Ala Leu Ser Leu Ser Asn Val Ala Gly 
                805                 810                 815     


Val Phe Tyr Ile Leu Val Gly Gly Leu Gly Leu Ala Met Leu Val Ala 
            820                 825                 830         


Leu Ile Glu Phe Cys Tyr Lys Ser Arg Ala Glu Ala Lys Arg Met Lys 
        835                 840                 845             


Val Ala Lys Ser Ala Gln Thr Phe Asn Pro Thr Ser Ser Gln Asn Thr 
    850                 855                 860                 


Gln Asn Leu Ala Thr Tyr Arg Glu Gly Tyr Asn Val Tyr Gly Thr Glu 
865                 870                 875                 880 


Ser Ile Lys Ile 
                


<210>  6219
<211>  433
<212>  PRT
<213>  Homo Sapiens

<400>  6219

Met Arg Ile Ile Ser Arg Gln Ile Val Leu Leu Phe Ser Gly Phe Trp 
1               5                   10                  15      


Gly Leu Ala Met Gly Ala Phe Pro Ser Ser Val Gln Ile Gly Gly Leu 
            20                  25                  30          


Phe Ile Arg Asn Thr Asp Gln Glu Tyr Thr Ala Phe Arg Leu Ala Ile 
        35                  40                  45              


Phe Leu His Asn Thr Ser Pro Asn Ala Ser Glu Ala Pro Phe Asn Leu 
    50                  55                  60                  


Val Pro His Val Asp Asn Ile Glu Thr Ala Asn Ser Phe Ala Val Thr 
65                  70                  75                  80  


Asn Ala Phe Cys Ser Gln Tyr Ser Arg Gly Val Phe Ala Ile Phe Gly 
                85                  90                  95      


Leu Tyr Asp Lys Arg Ser Val His Thr Leu Thr Ser Phe Cys Ser Ala 
            100                 105                 110         


Leu His Ile Ser Leu Ile Thr Pro Ser Phe Pro Thr Glu Gly Glu Ser 
        115                 120                 125             


Gln Phe Val Leu Gln Leu Arg Pro Ser Leu Arg Gly Ala Leu Leu Ser 
    130                 135                 140                 


Leu Leu Asp His Tyr Glu Trp Asn Cys Phe Val Phe Leu Tyr Asp Thr 
145                 150                 155                 160 


Asp Arg Gly Tyr Ser Ile Leu Gln Ala Ile Met Glu Lys Ala Gly Gln 
                165                 170                 175     


Asn Gly Trp His Val Ser Ala Ile Cys Val Glu Asn Phe Asn Asp Val 
            180                 185                 190         


Ser Tyr Arg Gln Leu Leu Glu Glu Leu Asp Arg Arg Gln Glu Lys Lys 
        195                 200                 205             


Phe Val Ile Asp Cys Glu Ile Glu Arg Leu Gln Asn Ile Leu Glu Gln 
    210                 215                 220                 


Ile Val Ser Val Gly Lys His Val Lys Gly Tyr His Tyr Ile Ile Ala 
225                 230                 235                 240 


Asn Leu Gly Phe Lys Asp Ile Ser Leu Glu Arg Phe Ile His Gly Gly 
                245                 250                 255     


Ala Asn Val Thr Gly Phe Gln Leu Val Asp Phe Asn Thr Pro Met Val 
            260                 265                 270         


Ile Lys Leu Met Asp Arg Trp Lys Lys Leu Asp Gln Arg Glu Tyr Pro 
        275                 280                 285             


Gly Ser Glu Thr Pro Pro Lys Tyr Thr Ser Ala Leu Thr Tyr Asp Gly 
    290                 295                 300                 


Val Leu Val Met Ala Glu Thr Phe Arg Ser Leu Arg Arg Gln Lys Ile 
305                 310                 315                 320 


Asp Ile Ser Arg Arg Gly Asn Ala Gly Asp Cys Leu Ala Asn Pro Ala 
                325                 330                 335     


Ala Pro Trp Gly Gln Gly Ile Asp Met Glu Arg Thr Leu Lys Gln Val 
            340                 345                 350         


Arg Ile Gln Gly Leu Thr Gly Asn Val Gln Phe Asp His Tyr Gly Arg 
        355                 360                 365             


Arg Val Asn Tyr Thr Met Asp Val Phe Glu Leu Lys Ser Thr Gly Pro 
    370                 375                 380                 


Arg Lys Val Gly Tyr Trp Asn Asp Met Asp Lys Leu Val Leu Ile Gln 
385                 390                 395                 400 


Asp Val Pro Thr Leu Gly Asn Asp Thr Ala Ala Ile Glu Asn Arg Thr 
                405                 410                 415     


Val Val Val Thr Thr Ile Met Pro Leu Met Lys Asn Pro Ile Leu Arg 
            420                 425                 430         


Asn 
    


<210>  6220
<211>  902
<212>  PRT
<213>  Homo Sapiens

<400>  6220

Met Arg Ile Ile Ser Arg Gln Ile Val Leu Leu Phe Ser Gly Phe Trp 
1               5                   10                  15      


Gly Leu Ala Met Gly Ala Phe Pro Ser Ser Val Gln Ile Gly Gly Leu 
            20                  25                  30          


Phe Ile Arg Asn Thr Asp Gln Glu Tyr Thr Ala Phe Arg Leu Ala Ile 
        35                  40                  45              


Phe Leu His Asn Thr Ser Pro Asn Ala Ser Glu Ala Pro Phe Asn Leu 
    50                  55                  60                  


Val Pro His Val Asp Asn Ile Glu Thr Ala Asn Ser Phe Ala Val Thr 
65                  70                  75                  80  


Asn Ala Phe Cys Ser Gln Tyr Ser Arg Gly Val Phe Ala Ile Phe Gly 
                85                  90                  95      


Leu Tyr Asp Lys Arg Ser Val His Thr Leu Thr Ser Phe Cys Ser Ala 
            100                 105                 110         


Leu His Ile Ser Leu Ile Thr Pro Ser Phe Pro Thr Glu Gly Glu Ser 
        115                 120                 125             


Gln Phe Val Leu Gln Leu Arg Pro Ser Leu Arg Gly Ala Leu Leu Ser 
    130                 135                 140                 


Leu Leu Asp His Tyr Glu Trp Asn Cys Phe Val Phe Leu Tyr Asp Thr 
145                 150                 155                 160 


Asp Arg Gly Tyr Ser Ile Leu Gln Ala Ile Met Glu Lys Ala Gly Gln 
                165                 170                 175     


Asn Gly Trp His Val Ser Ala Ile Cys Val Glu Asn Phe Asn Asp Val 
            180                 185                 190         


Ser Tyr Arg Gln Leu Leu Glu Glu Leu Asp Arg Arg Gln Glu Lys Lys 
        195                 200                 205             


Phe Val Ile Asp Cys Glu Ile Glu Arg Leu Gln Asn Ile Leu Glu Gln 
    210                 215                 220                 


Ile Val Ser Val Gly Lys His Val Lys Gly Tyr His Tyr Ile Ile Ala 
225                 230                 235                 240 


Asn Leu Gly Phe Lys Asp Ile Ser Leu Glu Arg Phe Ile His Gly Gly 
                245                 250                 255     


Ala Asn Val Thr Gly Phe Gln Leu Val Asp Phe Asn Thr Pro Met Val 
            260                 265                 270         


Ile Lys Leu Met Asp Arg Trp Lys Lys Leu Asp Gln Arg Glu Tyr Pro 
        275                 280                 285             


Gly Ser Glu Thr Pro Pro Lys Tyr Thr Ser Ala Leu Thr Tyr Asp Gly 
    290                 295                 300                 


Val Leu Val Met Ala Glu Thr Phe Arg Ser Leu Arg Arg Gln Lys Ile 
305                 310                 315                 320 


Asp Ile Ser Arg Arg Gly Asn Ala Gly Asp Cys Leu Ala Asn Pro Ala 
                325                 330                 335     


Ala Pro Trp Gly Gln Gly Ile Asp Met Glu Arg Thr Leu Lys Gln Val 
            340                 345                 350         


Arg Ile Gln Gly Leu Thr Gly Asn Val Gln Phe Asp His Tyr Gly Arg 
        355                 360                 365             


Arg Val Asn Tyr Thr Met Asp Val Phe Glu Leu Lys Ser Thr Gly Pro 
    370                 375                 380                 


Arg Lys Val Gly Tyr Trp Asn Asp Met Asp Lys Leu Val Leu Ile Gln 
385                 390                 395                 400 


Asp Val Pro Thr Leu Gly Asn Asp Thr Ala Ala Ile Glu Asn Arg Thr 
                405                 410                 415     


Val Val Val Thr Thr Ile Met Glu Ser Pro Tyr Val Met Tyr Lys Lys 
            420                 425                 430         


Asn His Glu Met Phe Glu Gly Asn Asp Lys Tyr Glu Gly Tyr Cys Val 
        435                 440                 445             


Asp Leu Ala Ser Glu Ile Ala Lys His Ile Gly Ile Lys Tyr Lys Ile 
    450                 455                 460                 


Ala Ile Val Pro Asp Gly Lys Tyr Gly Ala Arg Asp Ala Asp Thr Lys 
465                 470                 475                 480 


Ile Trp Asn Gly Met Val Gly Glu Leu Val Tyr Gly Lys Ala Glu Ile 
                485                 490                 495     


Ala Ile Ala Pro Leu Thr Ile Thr Leu Val Arg Glu Glu Val Ile Asp 
            500                 505                 510         


Phe Ser Lys Pro Phe Met Ser Leu Gly Ile Ser Ile Met Ile Lys Lys 
        515                 520                 525             


Pro Gln Lys Ser Lys Pro Gly Val Phe Ser Phe Leu Asp Pro Leu Ala 
    530                 535                 540                 


Tyr Glu Ile Trp Met Cys Ile Val Phe Ala Tyr Ile Gly Val Ser Val 
545                 550                 555                 560 


Val Leu Phe Leu Val Ser Arg Phe Ser Pro Tyr Glu Trp His Thr Glu 
                565                 570                 575     


Glu Pro Glu Asp Gly Lys Glu Gly Pro Ser Asp Gln Pro Pro Asn Glu 
            580                 585                 590         


Phe Gly Ile Phe Asn Ser Leu Trp Phe Ser Leu Gly Ala Phe Met Gln 
        595                 600                 605             


Gln Gly Cys Asp Ile Ser Pro Arg Ser Leu Ser Gly Arg Ile Val Gly 
    610                 615                 620                 


Gly Val Trp Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala 
625                 630                 635                 640 


Asn Leu Ala Ala Phe Leu Thr Val Glu Arg Met Val Ser Pro Ile Glu 
                645                 650                 655     


Ser Ala Glu Asp Leu Ala Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu 
            660                 665                 670         


Asp Ser Gly Ser Thr Lys Glu Phe Phe Arg Arg Ser Lys Ile Ala Val 
        675                 680                 685             


Tyr Glu Lys Met Trp Thr Tyr Met Arg Ser Ala Glu Pro Ser Val Phe 
    690                 695                 700                 


Thr Arg Thr Thr Ala Glu Gly Val Ala Arg Val Arg Lys Ser Lys Gly 
705                 710                 715                 720 


Lys Phe Ala Phe Leu Leu Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln 
                725                 730                 735     


Arg Lys Pro Cys Asp Thr Met Lys Val Gly Gly Asn Leu Asp Ser Lys 
            740                 745                 750         


Gly Tyr Gly Val Ala Thr Pro Lys Gly Ser Ser Leu Arg Thr Pro Val 
        755                 760                 765             


Asn Leu Ala Val Leu Lys Leu Ser Glu Ala Gly Val Leu Asp Lys Leu 
    770                 775                 780                 


Lys Asn Lys Trp Trp Tyr Asp Lys Gly Glu Cys Gly Pro Lys Asp Ser 
785                 790                 795                 800 


Gly Ser Lys Asp Lys Thr Ser Ala Leu Ser Leu Ser Asn Val Ala Gly 
                805                 810                 815     


Val Phe Tyr Ile Leu Val Gly Gly Leu Gly Leu Ala Met Leu Val Ala 
            820                 825                 830         


Leu Ile Glu Phe Cys Tyr Lys Ser Arg Ala Glu Ala Lys Arg Met Lys 
        835                 840                 845             


Leu Thr Phe Ser Glu Ala Ile Arg Asn Lys Ala Arg Leu Ser Ile Thr 
    850                 855                 860                 


Gly Ser Val Gly Glu Asn Gly Arg Val Leu Thr Pro Asp Cys Pro Lys 
865                 870                 875                 880 


Ala Val His Thr Gly Thr Ala Ile Arg Gln Ser Ser Gly Leu Ala Val 
                885                 890                 895     


Ile Ala Ser Asp Leu Pro 
            900         


<210>  6221
<211>  884
<212>  PRT
<213>  Homo Sapiens

<400>  6221

Met Arg Ile Ile Ser Arg Gln Ile Val Leu Leu Phe Ser Gly Phe Trp 
1               5                   10                  15      


Gly Leu Ala Met Gly Ala Phe Pro Ser Ser Val Gln Ile Gly Gly Leu 
            20                  25                  30          


Phe Ile Arg Asn Thr Asp Gln Glu Tyr Thr Ala Phe Arg Leu Ala Ile 
        35                  40                  45              


Phe Leu His Asn Thr Ser Pro Asn Ala Ser Glu Ala Pro Phe Asn Leu 
    50                  55                  60                  


Val Pro His Val Asp Asn Ile Glu Thr Ala Asn Ser Phe Ala Val Thr 
65                  70                  75                  80  


Asn Ala Phe Cys Ser Gln Tyr Ser Arg Gly Val Phe Ala Ile Phe Gly 
                85                  90                  95      


Leu Tyr Asp Lys Arg Ser Val His Thr Leu Thr Ser Phe Cys Ser Ala 
            100                 105                 110         


Leu His Ile Ser Leu Ile Thr Pro Ser Phe Pro Thr Glu Gly Glu Ser 
        115                 120                 125             


Gln Phe Val Leu Gln Leu Arg Pro Ser Leu Arg Gly Ala Leu Leu Ser 
    130                 135                 140                 


Leu Leu Asp His Tyr Glu Trp Asn Cys Phe Val Phe Leu Tyr Asp Thr 
145                 150                 155                 160 


Asp Arg Gly Tyr Ser Ile Leu Gln Ala Ile Met Glu Lys Ala Gly Gln 
                165                 170                 175     


Asn Gly Trp His Val Ser Ala Ile Cys Val Glu Asn Phe Asn Asp Val 
            180                 185                 190         


Ser Tyr Arg Gln Leu Leu Glu Glu Leu Asp Arg Arg Gln Glu Lys Lys 
        195                 200                 205             


Phe Val Ile Asp Cys Glu Ile Glu Arg Leu Gln Asn Ile Leu Glu Gln 
    210                 215                 220                 


Ile Val Ser Val Gly Lys His Val Lys Gly Tyr His Tyr Ile Ile Ala 
225                 230                 235                 240 


Asn Leu Gly Phe Lys Asp Ile Ser Leu Glu Arg Phe Ile His Gly Gly 
                245                 250                 255     


Ala Asn Val Thr Gly Phe Gln Leu Val Asp Phe Asn Thr Pro Met Val 
            260                 265                 270         


Ile Lys Leu Met Asp Arg Trp Lys Lys Leu Asp Gln Arg Glu Tyr Pro 
        275                 280                 285             


Gly Ser Glu Thr Pro Pro Lys Tyr Thr Ser Ala Leu Thr Tyr Asp Gly 
    290                 295                 300                 


Val Leu Val Met Ala Glu Thr Phe Arg Ser Leu Arg Arg Gln Lys Ile 
305                 310                 315                 320 


Asp Ile Ser Arg Arg Gly Asn Ala Gly Asp Cys Leu Ala Asn Pro Ala 
                325                 330                 335     


Ala Pro Trp Gly Gln Gly Ile Asp Met Glu Arg Thr Leu Lys Gln Val 
            340                 345                 350         


Arg Ile Gln Gly Leu Thr Gly Asn Val Gln Phe Asp His Tyr Gly Arg 
        355                 360                 365             


Arg Val Asn Tyr Thr Met Asp Val Phe Glu Leu Lys Ser Thr Gly Pro 
    370                 375                 380                 


Arg Lys Val Gly Tyr Trp Asn Asp Met Asp Lys Leu Val Leu Ile Gln 
385                 390                 395                 400 


Asp Val Pro Thr Leu Gly Asn Asp Thr Ala Ala Ile Glu Asn Arg Thr 
                405                 410                 415     


Val Val Val Thr Thr Ile Met Glu Ser Pro Tyr Val Met Tyr Lys Lys 
            420                 425                 430         


Asn His Glu Met Phe Glu Gly Asn Asp Lys Tyr Glu Gly Tyr Cys Val 
        435                 440                 445             


Asp Leu Ala Ser Glu Ile Ala Lys His Ile Gly Ile Lys Tyr Lys Ile 
    450                 455                 460                 


Ala Ile Val Pro Asp Gly Lys Tyr Gly Ala Arg Asp Ala Asp Thr Lys 
465                 470                 475                 480 


Ile Trp Asn Gly Met Val Gly Glu Leu Val Tyr Gly Lys Ala Glu Ile 
                485                 490                 495     


Ala Ile Ala Pro Leu Thr Ile Thr Leu Val Arg Glu Glu Val Ile Asp 
            500                 505                 510         


Phe Ser Lys Pro Phe Met Ser Leu Gly Ile Ser Ile Met Ile Lys Lys 
        515                 520                 525             


Pro Gln Lys Ser Lys Pro Gly Val Phe Ser Phe Leu Asp Pro Leu Ala 
    530                 535                 540                 


Tyr Glu Ile Trp Met Cys Ile Val Phe Ala Tyr Ile Gly Val Ser Val 
545                 550                 555                 560 


Val Leu Phe Leu Val Ser Arg Phe Ser Pro Tyr Glu Trp His Thr Glu 
                565                 570                 575     


Glu Pro Glu Asp Gly Lys Glu Gly Pro Ser Asp Gln Pro Pro Asn Glu 
            580                 585                 590         


Phe Gly Ile Phe Asn Ser Leu Trp Phe Ser Leu Gly Ala Phe Met Gln 
        595                 600                 605             


Gln Gly Cys Asp Ile Ser Pro Arg Ser Leu Ser Gly Arg Ile Val Gly 
    610                 615                 620                 


Gly Val Trp Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala 
625                 630                 635                 640 


Asn Leu Ala Ala Phe Leu Thr Val Glu Arg Met Val Ser Pro Ile Glu 
                645                 650                 655     


Ser Ala Glu Asp Leu Ala Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu 
            660                 665                 670         


Asp Ser Gly Ser Thr Lys Glu Phe Phe Arg Arg Ser Lys Ile Ala Val 
        675                 680                 685             


Tyr Glu Lys Met Trp Thr Tyr Met Arg Ser Ala Glu Pro Ser Val Phe 
    690                 695                 700                 


Thr Arg Thr Thr Ala Glu Gly Val Ala Arg Val Arg Lys Ser Lys Gly 
705                 710                 715                 720 


Lys Phe Ala Phe Leu Leu Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln 
                725                 730                 735     


Arg Lys Pro Cys Asp Thr Met Lys Val Gly Gly Asn Leu Asp Ser Lys 
            740                 745                 750         


Gly Tyr Gly Val Ala Thr Pro Lys Gly Ser Ser Leu Arg Asn Ala Val 
        755                 760                 765             


Asn Leu Ala Val Leu Lys Leu Asn Glu Gln Gly Leu Leu Asp Lys Leu 
    770                 775                 780                 


Lys Asn Lys Trp Trp Tyr Asp Lys Gly Glu Cys Gly Ser Gly Gly Gly 
785                 790                 795                 800 


Asp Ser Lys Asp Lys Thr Ser Ala Leu Ser Leu Ser Asn Val Ala Gly 
                805                 810                 815     


Val Phe Tyr Ile Leu Val Gly Gly Leu Gly Leu Ala Met Leu Val Ala 
            820                 825                 830         


Leu Ile Glu Phe Cys Tyr Lys Ser Arg Ala Glu Ala Lys Arg Met Lys 
        835                 840                 845             


Val Ala Lys Ser Ala Gln Thr Phe Asn Pro Thr Ser Ser Gln Asn Thr 
    850                 855                 860                 


Gln Asn Leu Ala Thr Tyr Arg Glu Gly Tyr Asn Val Tyr Gly Thr Glu 
865                 870                 875                 880 


Ser Ile Lys Ile 
                


<210>  6222
<211>  104
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6222

Xaa Val Ala Arg Val Arg Lys Ser Lys Gly Lys Phe Ala Phe Leu Leu 
1               5                   10                  15      


Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln Arg Lys Pro Cys Asp Thr 
            20                  25                  30          


Met Lys Val Gly Gly Asn Leu Asp Ser Lys Gly Tyr Gly Val Ala Thr 
        35                  40                  45              


Pro Lys Gly Ser Ser Leu Arg Asn Ala Val Asn Leu Ala Val Leu Lys 
    50                  55                  60                  


Leu Asn Glu Gln Gly Leu Leu Asp Lys Leu Lys Asn Lys Trp Trp Tyr 
65                  70                  75                  80  


Asp Lys Gly Glu Cys Gly Ser Gly Gly Gly Asp Ser Lys Asn Ser Cys 
                85                  90                  95      


Lys Pro Cys Arg Phe Glu Thr Gln 
            100                 


<210>  6223
<211>  180
<212>  PRT
<213>  Homo Sapiens

<400>  6223

Cys Ser His Glu Met Ala Ala Gly Ile Leu Lys Gln Ala Leu Ala Met 
1               5                   10                  15      


Gly Met Met Thr Glu Tyr Tyr His Tyr Ile Phe Thr Thr Leu Thr Asp 
            20                  25                  30          


Ala Ala Leu Met Tyr Asp Ala Val His Val Val Ser Val Ala Val Gln 
        35                  40                  45              


Gln Phe Pro Gln Met Thr Val Ser Ser Leu Gln Cys Asn Arg His Lys 
    50                  55                  60                  


Pro Trp Arg Phe Gly Thr Arg Phe Met Ser Leu Ile Lys Glu Ala His 
65                  70                  75                  80  


Trp Glu Gly Leu Thr Gly Arg Ile Thr Phe Asn Lys Thr Asn Gly Leu 
                85                  90                  95      


Arg Thr Asp Phe Asp Leu Asp Val Ile Ser Leu Lys Glu Glu Gly Leu 
            100                 105                 110         


Glu Lys Ile Gly Thr Trp Asp Pro Ala Ser Gly Leu Asn Met Thr Glu 
        115                 120                 125             


Ser Gln Lys Gly Lys Pro Ala Asn Ile Thr Asp Ser Leu Ser Asn Arg 
    130                 135                 140                 


Ser Leu Ile Val Thr Thr Ile Leu Glu Glu Pro Tyr Val Leu Phe Lys 
145                 150                 155                 160 


Lys Ser Asp Lys Pro Leu Tyr Gly Asn Asp Arg Phe Glu Gly Tyr Cys 
                165                 170                 175     


Ile Asp Leu Leu 
            180 


<210>  6224
<211>  854
<212>  PRT
<213>  Homo Sapiens

<400>  6224

Gly Gly Ile Phe Glu Tyr Val Glu Ser Gly Pro Met Gly Ala Glu Glu 
1               5                   10                  15      


Leu Ala Phe Arg Phe Ala Val Asn Thr Ile Asn Arg Asn Arg Thr Leu 
            20                  25                  30          


Leu Pro Asn Thr Thr Leu Thr Tyr Asp Thr Gln Lys Ile Asn Leu Tyr 
        35                  40                  45              


Asp Ser Phe Glu Ala Ser Lys Lys Ala Cys Asp Gln Leu Ser Leu Gly 
    50                  55                  60                  


Val Ala Ala Ile Phe Gly Pro Ser His Ser Ser Ser Ala Asn Ala Val 
65                  70                  75                  80  


Gln Ser Ile Cys Asn Ala Leu Gly Val Pro His Ile Gln Thr Arg Trp 
                85                  90                  95      


Lys His Gln Val Ser Asp Asn Lys Asp Ser Phe Tyr Val Ser Leu Tyr 
            100                 105                 110         


Pro Asp Phe Ser Ser Leu Ser Arg Ala Ile Leu Asp Leu Val Gln Phe 
        115                 120                 125             


Phe Lys Trp Lys Thr Val Thr Val Val Tyr Asp Asp Ser Thr Gly Leu 
    130                 135                 140                 


Ile Arg Leu Gln Glu Leu Ile Lys Ala Pro Ser Arg Tyr Asn Leu Arg 
145                 150                 155                 160 


Leu Lys Ile Arg Gln Leu Pro Ala Asp Thr Lys Asp Ala Lys Pro Leu 
                165                 170                 175     


Leu Lys Glu Met Lys Arg Gly Lys Glu Phe His Val Ile Phe Asp Cys 
            180                 185                 190         


Ser His Glu Met Ala Ala Gly Ile Leu Lys Gln Ala Leu Ala Met Gly 
        195                 200                 205             


Met Met Thr Glu Tyr Tyr His Tyr Ile Phe Thr Thr Leu Asp Leu Phe 
    210                 215                 220                 


Ala Leu Asp Val Glu Pro Tyr Arg Tyr Ser Gly Val Asn Met Thr Gly 
225                 230                 235                 240 


Phe Arg Ile Leu Asn Thr Glu Asn Thr Gln Val Ser Ser Ile Ile Glu 
                245                 250                 255     


Lys Trp Ser Met Glu Arg Leu Gln Ala Pro Pro Lys Pro Asp Ser Gly 
            260                 265                 270         


Leu Leu Asp Gly Phe Met Thr Thr Asp Ala Ala Leu Met Tyr Asp Ala 
        275                 280                 285             


Val His Val Val Ser Val Ala Val Gln Gln Phe Pro Gln Met Thr Val 
    290                 295                 300                 


Ser Ser Leu Gln Cys Asn Arg His Lys Pro Trp Arg Phe Gly Thr Arg 
305                 310                 315                 320 


Phe Met Ser Leu Ile Lys Glu Ala His Trp Glu Gly Leu Thr Gly Arg 
                325                 330                 335     


Ile Thr Phe Asn Lys Thr Asn Gly Leu Arg Thr Asp Phe Asp Leu Asp 
            340                 345                 350         


Val Ile Ser Leu Lys Glu Glu Gly Leu Glu Lys Ile Gly Thr Trp Asp 
        355                 360                 365             


Pro Ala Ser Gly Leu Asn Met Thr Glu Ser Gln Lys Gly Lys Pro Ala 
    370                 375                 380                 


Asn Ile Thr Asp Ser Leu Ser Asn Arg Ser Leu Ile Val Thr Thr Ile 
385                 390                 395                 400 


Leu Glu Glu Pro Tyr Val Leu Phe Lys Lys Ser Asp Lys Pro Leu Tyr 
                405                 410                 415     


Gly Asn Asp Arg Phe Glu Gly Tyr Cys Ile Asp Leu Leu Arg Glu Leu 
            420                 425                 430         


Ser Thr Ile Leu Gly Phe Thr Tyr Glu Ile Arg Leu Val Glu Asp Gly 
        435                 440                 445             


Lys Tyr Gly Ala Gln Asp Asp Ala Asn Gly Gln Trp Asn Gly Met Val 
    450                 455                 460                 


Arg Glu Leu Ile Asp His Lys Ala Asp Leu Ala Val Ala Pro Leu Ala 
465                 470                 475                 480 


Ile Thr Tyr Val Arg Glu Lys Val Ile Asp Phe Ser Lys Pro Phe Met 
                485                 490                 495     


Thr Leu Gly Ile Ser Ile Leu Tyr Arg Lys Pro Asn Gly Thr Asn Pro 
            500                 505                 510         


Gly Val Phe Ser Phe Leu Asn Pro Leu Ser Pro Asp Ile Trp Met Tyr 
        515                 520                 525             


Ile Leu Leu Ala Tyr Leu Gly Val Ser Cys Val Leu Phe Val Ile Ala 
    530                 535                 540                 


Arg Phe Ser Pro Tyr Glu Trp Tyr Asn Pro His Pro Cys Asn Pro Asp 
545                 550                 555                 560 


Ser Asp Val Val Glu Asn Asn Phe Thr Leu Leu Asn Ser Phe Trp Phe 
                565                 570                 575     


Gly Val Gly Ala Leu Met Gln Gln Gly Ser Glu Leu Met Pro Lys Ala 
            580                 585                 590         


Leu Ser Thr Arg Ile Val Gly Gly Ile Trp Trp Phe Phe Thr Leu Ile 
        595                 600                 605             


Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu Thr Val Glu 
    610                 615                 620                 


Arg Met Glu Ser Pro Ile Asp Ser Ala Asp Asp Leu Ala Lys Gln Thr 
625                 630                 635                 640 


Lys Ile Glu Tyr Gly Ala Val Glu Asp Gly Ala Thr Met Thr Phe Phe 
                645                 650                 655     


Lys Lys Ser Lys Ile Ser Thr Tyr Asp Lys Met Trp Ala Phe Met Ser 
            660                 665                 670         


Ser Arg Arg Gln Ser Val Leu Val Lys Ser Asn Glu Glu Gly Ile Gln 
        675                 680                 685             


Arg Val Leu Thr Ser Asp Tyr Ala Phe Leu Met Glu Ser Thr Thr Ile 
    690                 695                 700                 


Glu Phe Val Thr Gln Arg Asn Cys Asn Leu Thr Gln Ile Gly Gly Leu 
705                 710                 715                 720 


Ile Asp Ser Lys Gly Tyr Gly Val Gly Thr Pro Met Gly Ser Pro Tyr 
                725                 730                 735     


Arg Asp Lys Ile Thr Ile Ala Ile Leu Gln Leu Gln Glu Glu Gly Lys 
            740                 745                 750         


Leu His Met Met Lys Glu Lys Trp Trp Arg Gly Asn Gly Cys Pro Glu 
        755                 760                 765             


Glu Glu Ser Lys Glu Ala Ser Ala Leu Gly Val Gln Asn Ile Gly Gly 
    770                 775                 780                 


Ile Phe Ile Val Leu Ala Ala Gly Leu Val Leu Ser Val Phe Val Ala 
785                 790                 795                 800 


Val Gly Glu Phe Leu Tyr Lys Ser Lys Lys Asn Ala Gln Leu Glu Lys 
                805                 810                 815     


Arg Ala Lys Thr Lys Leu Pro Gln Asp Tyr Val Phe Leu Pro Ile Leu 
            820                 825                 830         


Glu Ser Val Ser Ile Ser Thr Val Leu Ser Ser Ser Pro Ser Ser Ser 
        835                 840                 845             


Ser Leu Ser Ser Cys Ser 
    850                 


<210>  6225
<211>  870
<212>  PRT
<213>  Homo Sapiens

<400>  6225

Gly Gly Ile Phe Glu Tyr Val Glu Ser Gly Pro Met Gly Ala Glu Glu 
1               5                   10                  15      


Leu Ala Phe Arg Phe Ala Val Asn Thr Ile Asn Arg Asn Arg Thr Leu 
            20                  25                  30          


Leu Pro Asn Thr Thr Leu Thr Tyr Asp Thr Gln Lys Ile Asn Leu Tyr 
        35                  40                  45              


Asp Ser Phe Glu Ala Ser Lys Lys Ala Cys Asp Gln Leu Ser Leu Gly 
    50                  55                  60                  


Val Ala Ala Ile Phe Gly Pro Ser His Ser Ser Ser Ala Asn Ala Val 
65                  70                  75                  80  


Gln Ser Ile Cys Asn Ala Leu Gly Val Pro His Ile Gln Thr Arg Trp 
                85                  90                  95      


Lys His Gln Val Ser Asp Asn Lys Asp Ser Phe Tyr Val Ser Leu Tyr 
            100                 105                 110         


Pro Asp Phe Ser Ser Leu Ser Arg Ala Ile Leu Asp Leu Val Gln Phe 
        115                 120                 125             


Phe Lys Trp Lys Thr Val Thr Val Val Tyr Asp Asp Ser Thr Gly Leu 
    130                 135                 140                 


Ile Arg Leu Gln Glu Leu Ile Lys Ala Pro Ser Arg Tyr Asn Leu Arg 
145                 150                 155                 160 


Leu Lys Ile Arg Gln Leu Pro Ala Asp Thr Lys Asp Ala Lys Pro Leu 
                165                 170                 175     


Leu Lys Glu Met Lys Arg Gly Lys Glu Phe His Val Ile Phe Asp Cys 
            180                 185                 190         


Ser His Glu Met Ala Ala Gly Ile Leu Lys Gln Ala Leu Ala Met Gly 
        195                 200                 205             


Met Met Thr Glu Tyr Tyr His Tyr Ile Phe Thr Thr Leu Asp Leu Phe 
    210                 215                 220                 


Ala Leu Asp Val Glu Pro Tyr Arg Tyr Ser Gly Val Asn Met Thr Gly 
225                 230                 235                 240 


Phe Arg Ile Leu Asn Thr Glu Asn Thr Gln Val Ser Ser Ile Ile Glu 
                245                 250                 255     


Lys Trp Ser Met Glu Arg Leu Gln Ala Pro Pro Lys Pro Asp Ser Gly 
            260                 265                 270         


Leu Leu Asp Gly Phe Met Thr Thr Asp Ala Ala Leu Met Tyr Asp Ala 
        275                 280                 285             


Val His Val Val Ser Val Ala Val Gln Gln Phe Pro Gln Met Thr Val 
    290                 295                 300                 


Ser Ser Leu Gln Cys Asn Arg His Lys Pro Trp Arg Phe Gly Thr Arg 
305                 310                 315                 320 


Phe Met Ser Leu Ile Lys Glu Ala His Trp Glu Gly Leu Thr Gly Arg 
                325                 330                 335     


Ile Thr Phe Asn Lys Thr Asn Gly Leu Arg Thr Asp Phe Asp Leu Asp 
            340                 345                 350         


Val Ile Ser Leu Lys Glu Glu Gly Leu Glu Lys Ile Gly Thr Trp Asp 
        355                 360                 365             


Pro Ala Ser Gly Leu Asn Met Thr Glu Ser Gln Lys Gly Lys Pro Ala 
    370                 375                 380                 


Asn Ile Thr Asp Ser Leu Ser Asn Arg Ser Leu Ile Val Thr Thr Ile 
385                 390                 395                 400 


Leu Glu Glu Pro Tyr Val Leu Phe Lys Lys Ser Asp Lys Pro Leu Tyr 
                405                 410                 415     


Gly Asn Asp Arg Phe Glu Gly Tyr Cys Ile Asp Leu Leu Arg Glu Leu 
            420                 425                 430         


Ser Thr Ile Leu Gly Phe Thr Tyr Glu Ile Arg Leu Val Glu Asp Gly 
        435                 440                 445             


Lys Tyr Gly Ala Gln Asp Asp Ala Asn Gly Gln Trp Asn Gly Met Val 
    450                 455                 460                 


Arg Glu Leu Ile Asp His Lys Ala Asp Leu Ala Val Ala Pro Leu Ala 
465                 470                 475                 480 


Ile Thr Tyr Val Arg Glu Lys Val Ile Asp Phe Ser Lys Pro Phe Met 
                485                 490                 495     


Thr Leu Gly Ile Ser Ile Leu Tyr Arg Lys Pro Asn Gly Thr Asn Pro 
            500                 505                 510         


Gly Val Phe Ser Phe Leu Asn Pro Leu Ser Pro Asp Ile Trp Met Tyr 
        515                 520                 525             


Ile Leu Leu Ala Tyr Leu Gly Val Ser Cys Val Leu Phe Val Ile Ala 
    530                 535                 540                 


Arg Phe Ser Pro Tyr Glu Trp Tyr Asn Pro His Pro Cys Asn Pro Asp 
545                 550                 555                 560 


Ser Asp Val Val Glu Asn Asn Phe Thr Leu Leu Asn Ser Phe Trp Phe 
                565                 570                 575     


Gly Val Gly Ala Leu Met Gln Gln Gly Ser Glu Leu Met Pro Lys Ala 
            580                 585                 590         


Leu Ser Thr Arg Ile Val Gly Gly Ile Trp Trp Phe Phe Thr Leu Ile 
        595                 600                 605             


Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu Thr Val Glu 
    610                 615                 620                 


Arg Met Glu Ser Pro Ile Asp Ser Ala Asp Asp Leu Ala Lys Gln Thr 
625                 630                 635                 640 


Lys Ile Glu Tyr Gly Ala Val Glu Asp Gly Ala Thr Met Thr Phe Phe 
                645                 650                 655     


Lys Lys Ser Lys Ile Ser Thr Tyr Asp Lys Met Trp Ala Phe Met Ser 
            660                 665                 670         


Ser Arg Arg Gln Ser Val Leu Val Lys Ser Asn Glu Glu Gly Ile Gln 
        675                 680                 685             


Arg Val Leu Thr Ser Asp Tyr Ala Phe Leu Met Glu Ser Thr Thr Ile 
    690                 695                 700                 


Glu Phe Val Thr Gln Arg Asn Cys Asn Leu Thr Gln Ile Gly Gly Leu 
705                 710                 715                 720 


Ile Asp Ser Lys Gly Tyr Gly Val Gly Thr Pro Met Gly Ser Pro Tyr 
                725                 730                 735     


Arg Asp Lys Ile Thr Ile Ala Ile Leu Gln Leu Gln Glu Glu Gly Lys 
            740                 745                 750         


Leu His Met Met Lys Glu Lys Trp Trp Arg Gly Asn Gly Cys Pro Glu 
        755                 760                 765             


Glu Glu Ser Lys Glu Ala Ser Ala Leu Gly Val Gln Asn Ile Gly Gly 
    770                 775                 780                 


Ile Phe Ile Val Leu Ala Ala Gly Leu Val Leu Ser Val Phe Val Ala 
785                 790                 795                 800 


Val Gly Glu Phe Leu Tyr Lys Ser Lys Lys Asn Ala Gln Leu Glu Lys 
                805                 810                 815     


Arg Ser Phe Cys Ser Ala Met Val Glu Glu Leu Arg Met Ser Leu Lys 
            820                 825                 830         


Cys Gln Arg Arg Leu Lys His Lys Pro Gln Ala Pro Val Ile Val Lys 
        835                 840                 845             


Thr Glu Glu Val Ile Asn Met His Thr Phe Asn Asp Arg Arg Leu Pro 
    850                 855                 860                 


Gly Lys Glu Thr Met Ala 
865                 870 


<210>  6226
<211>  831
<212>  PRT
<213>  Homo Sapiens

<400>  6226

Gly Gly Ile Phe Glu Tyr Val Glu Ser Gly Pro Met Gly Ala Glu Glu 
1               5                   10                  15      


Leu Ala Phe Arg Phe Ala Val Asn Thr Ile Asn Arg Asn Arg Thr Leu 
            20                  25                  30          


Leu Pro Asn Thr Thr Leu Thr Tyr Asp Thr Gln Lys Ile Asn Leu Tyr 
        35                  40                  45              


Asp Ser Phe Glu Ala Ser Lys Lys Ala Cys Asp Gln Leu Ser Leu Gly 
    50                  55                  60                  


Val Ala Ala Ile Phe Gly Pro Ser His Ser Ser Ser Ala Asn Ala Val 
65                  70                  75                  80  


Gln Ser Ile Cys Asn Ala Leu Gly Val Pro His Ile Gln Thr Arg Trp 
                85                  90                  95      


Lys His Gln Val Ser Asp Asn Lys Asp Ser Phe Tyr Val Ser Leu Tyr 
            100                 105                 110         


Pro Asp Phe Ser Ser Leu Ser Arg Ala Ile Leu Asp Leu Val Gln Phe 
        115                 120                 125             


Phe Lys Trp Lys Thr Val Thr Val Val Tyr Asp Asp Ser Thr Gly Leu 
    130                 135                 140                 


Ile Arg Leu Gln Glu Leu Ile Lys Ala Pro Ser Arg Tyr Asn Leu Arg 
145                 150                 155                 160 


Leu Lys Ile Arg Gln Leu Pro Ala Asp Thr Lys Asp Ala Lys Pro Leu 
                165                 170                 175     


Leu Lys Glu Met Lys Arg Gly Lys Glu Phe His Val Ile Phe Asp Cys 
            180                 185                 190         


Ser His Glu Met Ala Ala Gly Ile Leu Lys Gln Ala Leu Ala Met Gly 
        195                 200                 205             


Met Met Thr Glu Tyr Tyr His Tyr Ile Phe Thr Thr Leu Asp Leu Phe 
    210                 215                 220                 


Ala Leu Asp Val Glu Pro Tyr Arg Tyr Ser Gly Val Asn Met Thr Gly 
225                 230                 235                 240 


Phe Arg Ile Leu Asn Thr Glu Asn Thr Gln Val Ser Ser Ile Ile Glu 
                245                 250                 255     


Lys Trp Ser Met Glu Arg Leu Gln Ala Pro Pro Lys Pro Asp Ser Gly 
            260                 265                 270         


Leu Leu Asp Gly Phe Met Thr Thr Asp Ala Ala Leu Met Tyr Asp Ala 
        275                 280                 285             


Val His Val Val Ser Val Ala Val Gln Gln Phe Pro Gln Met Thr Val 
    290                 295                 300                 


Ser Ser Leu Gln Cys Asn Arg His Lys Pro Trp Arg Phe Gly Thr Arg 
305                 310                 315                 320 


Phe Met Ser Leu Ile Lys Glu Ala His Trp Glu Gly Leu Thr Gly Arg 
                325                 330                 335     


Ile Thr Phe Asn Lys Thr Asn Gly Leu Arg Thr Asp Phe Asp Leu Asp 
            340                 345                 350         


Val Ile Ser Leu Lys Glu Glu Gly Leu Glu Lys Ile Gly Thr Trp Asp 
        355                 360                 365             


Pro Ala Ser Gly Leu Asn Met Thr Glu Ser Gln Lys Gly Lys Pro Ala 
    370                 375                 380                 


Asn Ile Thr Asp Ser Leu Ser Asn Arg Ser Leu Ile Val Thr Thr Ile 
385                 390                 395                 400 


Leu Glu Glu Pro Tyr Val Leu Phe Lys Lys Ser Asp Lys Pro Leu Tyr 
                405                 410                 415     


Gly Asn Asp Arg Phe Glu Gly Tyr Cys Ile Asp Leu Leu Arg Glu Leu 
            420                 425                 430         


Ser Thr Ile Leu Gly Phe Thr Tyr Glu Ile Arg Leu Val Glu Asp Gly 
        435                 440                 445             


Lys Tyr Gly Ala Gln Asp Asp Ala Asn Gly Gln Trp Asn Gly Met Val 
    450                 455                 460                 


Arg Glu Leu Ile Asp His Lys Ala Asp Leu Ala Val Ala Pro Leu Ala 
465                 470                 475                 480 


Ile Thr Tyr Val Arg Glu Lys Val Ile Asp Phe Ser Lys Pro Phe Met 
                485                 490                 495     


Thr Leu Gly Ile Ser Ile Leu Tyr Arg Lys Pro Asn Gly Thr Asn Pro 
            500                 505                 510         


Gly Val Phe Ser Phe Leu Asn Pro Leu Ser Pro Asp Ile Trp Met Tyr 
        515                 520                 525             


Ile Leu Leu Ala Tyr Leu Gly Val Ser Cys Val Leu Phe Val Ile Ala 
    530                 535                 540                 


Arg Phe Ser Pro Tyr Glu Trp Tyr Asn Pro His Pro Cys Asn Pro Asp 
545                 550                 555                 560 


Ser Asp Val Val Glu Asn Asn Phe Thr Leu Leu Asn Ser Phe Trp Phe 
                565                 570                 575     


Gly Val Gly Ala Leu Met Gln Gln Gly Ser Glu Leu Met Pro Lys Ala 
            580                 585                 590         


Leu Ser Thr Arg Ile Val Gly Gly Ile Trp Trp Phe Phe Thr Leu Ile 
        595                 600                 605             


Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu Thr Val Glu 
    610                 615                 620                 


Arg Met Glu Ser Pro Ile Asp Ser Ala Asp Asp Leu Ala Lys Gln Thr 
625                 630                 635                 640 


Lys Ile Glu Tyr Gly Ala Val Glu Asp Gly Ala Thr Met Thr Phe Phe 
                645                 650                 655     


Lys Lys Ser Lys Ile Ser Thr Tyr Asp Lys Met Trp Ala Phe Met Ser 
            660                 665                 670         


Ser Arg Arg Gln Ser Val Leu Val Lys Ser Asn Glu Glu Gly Ile Gln 
        675                 680                 685             


Arg Val Leu Thr Ser Asp Tyr Ala Phe Leu Met Glu Ser Thr Thr Ile 
    690                 695                 700                 


Glu Phe Val Thr Gln Arg Asn Cys Asn Leu Thr Gln Ile Gly Gly Leu 
705                 710                 715                 720 


Ile Asp Ser Lys Gly Tyr Gly Val Gly Thr Pro Met Gly Ser Pro Tyr 
                725                 730                 735     


Arg Asp Lys Ile Thr Ile Ala Ile Leu Gln Leu Gln Glu Glu Gly Lys 
            740                 745                 750         


Leu His Met Met Lys Glu Lys Trp Trp Arg Gly Asn Gly Cys Pro Glu 
        755                 760                 765             


Glu Glu Ser Lys Glu Ala Ser Ala Leu Gly Val Gln Asn Ile Gly Gly 
    770                 775                 780                 


Ile Phe Ile Val Leu Ala Ala Gly Leu Val Leu Ser Val Phe Val Ala 
785                 790                 795                 800 


Val Gly Glu Phe Leu Tyr Lys Ser Lys Lys Asn Ala Gln Leu Glu Lys 
                805                 810                 815     


Glu Ser Ser Ile Trp Leu Val Pro Pro Tyr His Pro Asp Thr Val 
            820                 825                 830     


<210>  6227
<211>  182
<212>  PRT
<213>  Homo Sapiens

<400>  6227

Ile Gly Thr Trp Asp Pro Ala Ser Gly Leu Asn Met Thr Glu Ser Gln 
1               5                   10                  15      


Lys Gly Lys Pro Ala Asn Ile Thr Asp Ser Leu Ser Asn Arg Ser Leu 
            20                  25                  30          


Ile Val Thr Thr Ile Leu Glu Glu Pro Tyr Val Leu Phe Lys Lys Ser 
        35                  40                  45              


Asp Lys Pro Leu Tyr Gly Asn Asp Arg Phe Glu Gly Tyr Cys Ile Asp 
    50                  55                  60                  


Leu Leu Arg Glu Leu Ser Thr Ile Leu Gly Phe Thr Tyr Glu Ile Arg 
65                  70                  75                  80  


Leu Val Glu Asp Gly Lys Tyr Gly Ala Gln Asp Asp Ala Asn Gly Gln 
                85                  90                  95      


Trp Asn Gly Met Val Arg Glu Leu Ile Asp His Lys Ala Asp Leu Ala 
            100                 105                 110         


Val Ala Pro Leu Ala Ile Thr Tyr Val Arg Glu Lys Val Ile Asp Phe 
        115                 120                 125             


Ser Lys Pro Phe Met Thr Leu Gly Ile Ser Ile Leu Tyr Arg Lys Pro 
    130                 135                 140                 


Asn Gly Thr Asn Pro Gly Val Phe Ser Phe Leu Asn Pro Leu Ser Pro 
145                 150                 155                 160 


Asp Ile Trp Met Tyr Ile Leu Leu Ala Tyr Leu Gly Val Ser Cys Val 
                165                 170                 175     


Leu Phe Val Ile Ala Arg 
            180         


<210>  6228
<211>  892
<212>  PRT
<213>  Homo Sapiens

<400>  6228

Met Lys Ile Ile Phe Pro Ile Leu Ser Asn Pro Val Phe Arg Arg Thr 
1               5                   10                  15      


Val Lys Leu Leu Leu Cys Leu Leu Trp Ile Gly Tyr Ser Gln Gly Thr 
            20                  25                  30          


Thr His Val Leu Arg Phe Gly Gly Ile Phe Glu Tyr Val Glu Ser Gly 
        35                  40                  45              


Pro Met Gly Ala Glu Glu Leu Ala Phe Arg Phe Ala Val Asn Thr Ile 
    50                  55                  60                  


Asn Arg Asn Arg Thr Leu Leu Pro Asn Thr Thr Leu Thr Tyr Asp Thr 
65                  70                  75                  80  


Gln Lys Ile Asn Leu Tyr Asp Ser Phe Glu Ala Ser Lys Lys Ala Cys 
                85                  90                  95      


Asp Gln Leu Ser Leu Gly Val Ala Ala Ile Phe Gly Pro Ser His Ser 
            100                 105                 110         


Ser Ser Ala Asn Ala Val Gln Ser Ile Cys Asn Ala Leu Gly Val Pro 
        115                 120                 125             


His Ile Gln Thr Arg Trp Lys His Gln Val Ser Asp Asn Lys Asp Ser 
    130                 135                 140                 


Phe Tyr Val Ser Leu Tyr Pro Asp Phe Ser Ser Leu Ser Arg Ala Ile 
145                 150                 155                 160 


Leu Asp Leu Val Gln Phe Phe Lys Trp Lys Thr Val Thr Val Val Tyr 
                165                 170                 175     


Asp Asp Ser Thr Gly Leu Ile Arg Leu Gln Glu Leu Ile Lys Ala Pro 
            180                 185                 190         


Ser Arg Tyr Asn Leu Arg Leu Lys Ile Arg Gln Leu Pro Ala Asp Thr 
        195                 200                 205             


Lys Asp Ala Lys Pro Leu Leu Lys Glu Met Lys Arg Gly Lys Glu Phe 
    210                 215                 220                 


His Val Ile Phe Asp Cys Ser His Glu Met Ala Ala Gly Ile Leu Lys 
225                 230                 235                 240 


Gln Ala Leu Ala Met Gly Met Met Thr Glu Tyr Tyr His Tyr Ile Phe 
                245                 250                 255     


Thr Thr Leu Asp Leu Phe Ala Leu Asp Val Glu Pro Tyr Arg Tyr Ser 
            260                 265                 270         


Gly Val Asn Met Thr Gly Phe Arg Ile Leu Asn Thr Glu Asn Thr Gln 
        275                 280                 285             


Val Ser Ser Ile Ile Glu Lys Trp Ser Met Glu Arg Leu Gln Ala Pro 
    290                 295                 300                 


Pro Lys Pro Asp Ser Gly Leu Leu Asp Gly Phe Met Thr Thr Asp Ala 
305                 310                 315                 320 


Ala Leu Met Tyr Asp Ala Val His Val Val Ser Val Ala Val Gln Gln 
                325                 330                 335     


Phe Pro Gln Met Thr Val Ser Ser Leu Gln Cys Asn Arg His Lys Pro 
            340                 345                 350         


Trp Arg Phe Gly Thr Arg Phe Met Ser Leu Ile Lys Glu Ala His Trp 
        355                 360                 365             


Glu Gly Leu Thr Gly Arg Ile Thr Phe Asn Lys Thr Asn Gly Leu Arg 
    370                 375                 380                 


Thr Asp Phe Asp Leu Asp Val Ile Ser Leu Lys Glu Glu Gly Leu Glu 
385                 390                 395                 400 


Lys Ile Gly Thr Trp Asp Pro Ala Ser Gly Leu Asn Met Thr Glu Ser 
                405                 410                 415     


Gln Lys Gly Lys Pro Ala Asn Ile Thr Asp Ser Leu Ser Asn Arg Ser 
            420                 425                 430         


Leu Ile Val Thr Thr Ile Leu Glu Glu Pro Tyr Val Leu Phe Lys Lys 
        435                 440                 445             


Ser Asp Lys Pro Leu Tyr Gly Asn Asp Arg Phe Glu Gly Tyr Cys Ile 
    450                 455                 460                 


Asp Leu Leu Arg Glu Leu Ser Thr Ile Leu Gly Phe Thr Tyr Glu Ile 
465                 470                 475                 480 


Arg Leu Val Glu Asp Gly Lys Tyr Gly Ala Gln Asp Asp Ala Asn Gly 
                485                 490                 495     


Gln Trp Asn Gly Met Val Arg Glu Leu Ile Asp His Lys Ala Asp Leu 
            500                 505                 510         


Ala Val Ala Pro Leu Ala Ile Thr Tyr Val Arg Glu Lys Val Ile Asp 
        515                 520                 525             


Phe Ser Lys Pro Phe Met Thr Leu Gly Ile Ser Ile Leu Tyr Arg Lys 
    530                 535                 540                 


Pro Asn Gly Thr Asn Pro Gly Val Phe Ser Phe Leu Asn Pro Leu Ser 
545                 550                 555                 560 


Pro Asp Ile Trp Met Tyr Ile Leu Leu Ala Tyr Leu Gly Val Ser Cys 
                565                 570                 575     


Val Leu Phe Val Ile Ala Arg Phe Ser Pro Tyr Glu Trp Tyr Asn Pro 
            580                 585                 590         


His Pro Cys Asn Pro Asp Ser Asp Val Val Glu Asn Asn Phe Thr Leu 
        595                 600                 605             


Leu Asn Ser Phe Trp Phe Gly Val Gly Ala Leu Met Gln Gln Gly Ser 
    610                 615                 620                 


Glu Leu Met Pro Lys Ala Leu Ser Thr Arg Ile Val Gly Gly Ile Trp 
625                 630                 635                 640 


Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala 
                645                 650                 655     


Ala Phe Leu Thr Val Glu Arg Met Glu Ser Pro Ile Asp Ser Ala Asp 
            660                 665                 670         


Asp Leu Ala Lys Gln Thr Lys Ile Glu Tyr Gly Ala Val Glu Asp Gly 
        675                 680                 685             


Ala Thr Met Thr Phe Phe Lys Lys Ser Lys Ile Ser Thr Tyr Asp Lys 
    690                 695                 700                 


Met Trp Ala Phe Met Ser Ser Arg Arg Gln Ser Val Leu Val Lys Ser 
705                 710                 715                 720 


Asn Glu Glu Gly Ile Gln Arg Val Leu Thr Ser Asp Tyr Ala Phe Leu 
                725                 730                 735     


Met Glu Ser Thr Thr Ile Glu Phe Val Thr Gln Arg Asn Cys Asn Leu 
            740                 745                 750         


Thr Gln Ile Gly Gly Leu Ile Asp Ser Lys Gly Tyr Gly Val Gly Thr 
        755                 760                 765             


Pro Met Gly Ser Pro Tyr Arg Asp Lys Ile Thr Ile Ala Ile Leu Gln 
    770                 775                 780                 


Leu Gln Glu Glu Gly Lys Leu His Met Met Lys Glu Lys Trp Trp Arg 
785                 790                 795                 800 


Gly Asn Gly Cys Pro Glu Glu Glu Ser Lys Glu Ala Ser Ala Leu Gly 
                805                 810                 815     


Val Gln Asn Ile Gly Gly Ile Phe Ile Val Leu Ala Ala Gly Leu Val 
            820                 825                 830         


Leu Ser Val Phe Val Ala Val Gly Glu Phe Leu Tyr Lys Ser Lys Lys 
        835                 840                 845             


Asn Ala Gln Leu Glu Lys Arg Ala Lys Thr Lys Leu Pro Gln Asp Tyr 
    850                 855                 860                 


Val Phe Leu Pro Ile Leu Glu Ser Val Ser Ile Ser Thr Val Leu Ser 
865                 870                 875                 880 


Ser Ser Pro Ser Ser Ser Ser Leu Ser Ser Cys Ser 
                885                 890         


<210>  6229
<211>  353
<212>  PRT
<213>  Homo Sapiens

<400>  6229

Met Lys Ile Ile Phe Pro Ile Leu Ser Asn Pro Val Phe Arg Arg Thr 
1               5                   10                  15      


Val Lys Leu Leu Leu Cys Leu Leu Trp Ile Gly Tyr Ser Gln Gly Thr 
            20                  25                  30          


Thr His Val Leu Arg Phe Gly Gly Ile Phe Glu Tyr Val Glu Ser Gly 
        35                  40                  45              


Pro Met Gly Ala Glu Glu Leu Ala Phe Arg Phe Ala Val Asn Thr Ile 
    50                  55                  60                  


Asn Arg Asn Arg Thr Leu Leu Pro Asn Thr Thr Leu Thr Tyr Asp Thr 
65                  70                  75                  80  


Gln Lys Ile Asn Leu Tyr Asp Ser Phe Glu Ala Ser Lys Lys Ala Cys 
                85                  90                  95      


Asp Gln Leu Ser Leu Gly Val Ala Ala Ile Phe Gly Pro Ser His Ser 
            100                 105                 110         


Ser Ser Ala Asn Ala Val Gln Ser Ile Cys Asn Ala Leu Gly Val Pro 
        115                 120                 125             


His Ile Gln Thr Arg Trp Lys His Gln Val Ser Asp Asn Lys Asp Ser 
    130                 135                 140                 


Phe Tyr Val Ser Leu Tyr Pro Asp Phe Ser Ser Leu Ser Arg Ala Ile 
145                 150                 155                 160 


Leu Asp Leu Val Gln Phe Phe Lys Trp Lys Thr Val Thr Val Val Tyr 
                165                 170                 175     


Asp Asp Ser Thr Gly Leu Ile Arg Leu Gln Glu Leu Ile Lys Ala Pro 
            180                 185                 190         


Ser Arg Tyr Asn Leu Arg Leu Lys Ile Arg Gln Leu Pro Ala Asp Thr 
        195                 200                 205             


Lys Asp Ala Lys Pro Leu Leu Lys Glu Met Lys Arg Gly Lys Glu Phe 
    210                 215                 220                 


His Val Ile Phe Asp Cys Ser His Glu Met Ala Ala Gly Ile Leu Lys 
225                 230                 235                 240 


Gln Ala Leu Ala Met Gly Met Met Thr Glu Tyr Tyr His Tyr Ile Phe 
                245                 250                 255     


Thr Thr Leu Asp Leu Phe Ala Leu Asp Val Glu Pro Tyr Arg Tyr Ser 
            260                 265                 270         


Gly Val Asn Met Thr Gly Phe Arg Ile Leu Asn Thr Glu Asn Thr Gln 
        275                 280                 285             


Val Ser Ser Ile Ile Glu Lys Trp Ser Met Glu Arg Leu Gln Ala Pro 
    290                 295                 300                 


Pro Lys Pro Asp Ser Gly Leu Leu Asp Gly Phe Met Thr Met Glu Phe 
305                 310                 315                 320 


His Ser Cys Cys Pro Gly Trp Ser Ala Met Ala Arg Ser Gln Leu Thr 
                325                 330                 335     


Ala Thr Ser Ala Ser Trp Val Gln Ala Ile Leu Leu Pro Gln Pro Pro 
            340                 345                 350         


Glu 
    


<210>  6230
<211>  869
<212>  PRT
<213>  Homo Sapiens

<400>  6230

Met Lys Ile Ile Phe Pro Ile Leu Ser Asn Pro Val Phe Arg Arg Thr 
1               5                   10                  15      


Val Lys Leu Leu Leu Cys Leu Leu Trp Ile Gly Tyr Ser Gln Gly Thr 
            20                  25                  30          


Thr His Val Leu Arg Phe Gly Gly Ile Phe Glu Tyr Val Glu Ser Gly 
        35                  40                  45              


Pro Met Gly Ala Glu Glu Leu Ala Phe Arg Phe Ala Val Asn Thr Ile 
    50                  55                  60                  


Asn Arg Asn Arg Thr Leu Leu Pro Asn Thr Thr Leu Thr Tyr Asp Thr 
65                  70                  75                  80  


Gln Lys Ile Asn Leu Tyr Asp Ser Phe Glu Ala Ser Lys Lys Ala Cys 
                85                  90                  95      


Asp Gln Leu Ser Leu Gly Val Ala Ala Ile Phe Gly Pro Ser His Ser 
            100                 105                 110         


Ser Ser Ala Asn Ala Val Gln Ser Ile Cys Asn Ala Leu Gly Val Pro 
        115                 120                 125             


His Ile Gln Thr Arg Trp Lys His Gln Val Ser Asp Asn Lys Asp Ser 
    130                 135                 140                 


Phe Tyr Val Ser Leu Tyr Pro Asp Phe Ser Ser Leu Ser Arg Ala Ile 
145                 150                 155                 160 


Leu Asp Leu Val Gln Phe Phe Lys Trp Lys Thr Val Thr Val Val Tyr 
                165                 170                 175     


Asp Asp Ser Thr Gly Leu Ile Arg Leu Gln Glu Leu Ile Lys Ala Pro 
            180                 185                 190         


Ser Arg Tyr Asn Leu Arg Leu Lys Ile Arg Gln Leu Pro Ala Asp Thr 
        195                 200                 205             


Lys Asp Ala Lys Pro Leu Leu Lys Glu Met Lys Arg Gly Lys Glu Phe 
    210                 215                 220                 


His Val Ile Phe Asp Cys Ser His Glu Met Ala Ala Gly Ile Leu Lys 
225                 230                 235                 240 


Gln Ala Leu Ala Met Gly Met Met Thr Glu Tyr Tyr His Tyr Ile Phe 
                245                 250                 255     


Thr Thr Leu Asp Leu Phe Ala Leu Asp Val Glu Pro Tyr Arg Tyr Ser 
            260                 265                 270         


Gly Val Asn Met Thr Gly Phe Arg Ile Leu Asn Thr Glu Asn Thr Gln 
        275                 280                 285             


Val Ser Ser Ile Ile Glu Lys Trp Ser Met Glu Arg Leu Gln Ala Pro 
    290                 295                 300                 


Pro Lys Pro Asp Ser Gly Leu Leu Asp Gly Phe Met Thr Thr Asp Ala 
305                 310                 315                 320 


Ala Leu Met Tyr Asp Ala Val His Val Val Ser Val Ala Val Gln Gln 
                325                 330                 335     


Phe Pro Gln Met Thr Val Ser Ser Leu Gln Cys Asn Arg His Lys Pro 
            340                 345                 350         


Trp Arg Phe Gly Thr Arg Phe Met Ser Leu Ile Lys Glu Ala His Trp 
        355                 360                 365             


Glu Gly Leu Thr Gly Arg Ile Thr Phe Asn Lys Thr Asn Gly Leu Arg 
    370                 375                 380                 


Thr Asp Phe Asp Leu Asp Val Ile Ser Leu Lys Glu Glu Gly Leu Glu 
385                 390                 395                 400 


Lys Ile Gly Thr Trp Asp Pro Ala Ser Gly Leu Asn Met Thr Glu Ser 
                405                 410                 415     


Gln Lys Gly Lys Pro Ala Asn Ile Thr Asp Ser Leu Ser Asn Arg Ser 
            420                 425                 430         


Leu Ile Val Thr Thr Ile Leu Glu Glu Pro Tyr Val Leu Phe Lys Lys 
        435                 440                 445             


Ser Asp Lys Pro Leu Tyr Gly Asn Asp Arg Phe Glu Gly Tyr Cys Ile 
    450                 455                 460                 


Asp Leu Leu Arg Glu Leu Ser Thr Ile Leu Gly Phe Thr Tyr Glu Ile 
465                 470                 475                 480 


Arg Leu Val Glu Asp Gly Lys Tyr Gly Ala Gln Asp Asp Ala Asn Gly 
                485                 490                 495     


Gln Trp Asn Gly Met Val Arg Glu Leu Ile Asp His Lys Ala Asp Leu 
            500                 505                 510         


Ala Val Ala Pro Leu Ala Ile Thr Tyr Val Arg Glu Lys Val Ile Asp 
        515                 520                 525             


Phe Ser Lys Pro Phe Met Thr Leu Gly Ile Ser Ile Leu Tyr Arg Lys 
    530                 535                 540                 


Pro Asn Gly Thr Asn Pro Gly Val Phe Ser Phe Leu Asn Pro Leu Ser 
545                 550                 555                 560 


Pro Asp Ile Trp Met Tyr Ile Leu Leu Ala Tyr Leu Gly Val Ser Cys 
                565                 570                 575     


Val Leu Phe Val Ile Ala Arg Phe Ser Pro Tyr Glu Trp Tyr Asn Pro 
            580                 585                 590         


His Pro Cys Asn Pro Asp Ser Asp Val Val Glu Asn Asn Phe Thr Leu 
        595                 600                 605             


Leu Asn Ser Phe Trp Phe Gly Val Gly Ala Leu Met Gln Gln Gly Ser 
    610                 615                 620                 


Glu Leu Met Pro Lys Ala Leu Ser Thr Arg Ile Val Gly Gly Ile Trp 
625                 630                 635                 640 


Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala 
                645                 650                 655     


Ala Phe Leu Thr Val Glu Arg Met Glu Ser Pro Ile Asp Ser Ala Asp 
            660                 665                 670         


Asp Leu Ala Lys Gln Thr Lys Ile Glu Tyr Gly Ala Val Glu Asp Gly 
        675                 680                 685             


Ala Thr Met Thr Phe Phe Lys Lys Ser Lys Ile Ser Thr Tyr Asp Lys 
    690                 695                 700                 


Met Trp Ala Phe Met Ser Ser Arg Arg Gln Ser Val Leu Val Lys Ser 
705                 710                 715                 720 


Asn Glu Glu Gly Ile Gln Arg Val Leu Thr Ser Asp Tyr Ala Phe Leu 
                725                 730                 735     


Met Glu Ser Thr Thr Ile Glu Phe Val Thr Gln Arg Asn Cys Asn Leu 
            740                 745                 750         


Thr Gln Ile Gly Gly Leu Ile Asp Ser Lys Gly Tyr Gly Val Gly Thr 
        755                 760                 765             


Pro Met Gly Ser Pro Tyr Arg Asp Lys Ile Thr Ile Ala Ile Leu Gln 
    770                 775                 780                 


Leu Gln Glu Glu Gly Lys Leu His Met Met Lys Glu Lys Trp Trp Arg 
785                 790                 795                 800 


Gly Asn Gly Cys Pro Glu Glu Glu Ser Lys Glu Ala Ser Ala Leu Gly 
                805                 810                 815     


Val Gln Asn Ile Gly Gly Ile Phe Ile Val Leu Ala Ala Gly Leu Val 
            820                 825                 830         


Leu Ser Val Phe Val Ala Val Gly Glu Phe Leu Tyr Lys Ser Lys Lys 
        835                 840                 845             


Asn Ala Gln Leu Glu Lys Glu Ser Ser Ile Trp Leu Val Pro Pro Tyr 
    850                 855                 860                 


His Pro Asp Thr Val 
865                 


<210>  6231
<211>  908
<212>  PRT
<213>  Homo Sapiens

<400>  6231

Met Lys Ile Ile Phe Pro Ile Leu Ser Asn Pro Val Phe Arg Arg Thr 
1               5                   10                  15      


Val Lys Leu Leu Leu Cys Leu Leu Trp Ile Gly Tyr Ser Gln Gly Thr 
            20                  25                  30          


Thr His Val Leu Arg Phe Gly Gly Ile Phe Glu Tyr Val Glu Ser Gly 
        35                  40                  45              


Pro Met Gly Ala Glu Glu Leu Ala Phe Arg Phe Ala Val Asn Thr Ile 
    50                  55                  60                  


Asn Arg Asn Arg Thr Leu Leu Pro Asn Thr Thr Leu Thr Tyr Asp Thr 
65                  70                  75                  80  


Gln Lys Ile Asn Leu Tyr Asp Ser Phe Glu Ala Ser Lys Lys Ala Cys 
                85                  90                  95      


Asp Gln Leu Ser Leu Gly Val Ala Ala Ile Phe Gly Pro Ser His Ser 
            100                 105                 110         


Ser Ser Ala Asn Ala Val Gln Ser Ile Cys Asn Ala Leu Gly Val Pro 
        115                 120                 125             


His Ile Gln Thr Arg Trp Lys His Gln Val Ser Asp Asn Lys Asp Ser 
    130                 135                 140                 


Phe Tyr Val Ser Leu Tyr Pro Asp Phe Ser Ser Leu Ser Arg Ala Ile 
145                 150                 155                 160 


Leu Asp Leu Val Gln Phe Phe Lys Trp Lys Thr Val Thr Val Val Tyr 
                165                 170                 175     


Asp Asp Ser Thr Gly Leu Ile Arg Leu Gln Glu Leu Ile Lys Ala Pro 
            180                 185                 190         


Ser Arg Tyr Asn Leu Arg Leu Lys Ile Arg Gln Leu Pro Ala Asp Thr 
        195                 200                 205             


Lys Asp Ala Lys Pro Leu Leu Lys Glu Met Lys Arg Gly Lys Glu Phe 
    210                 215                 220                 


His Val Ile Phe Asp Cys Ser His Glu Met Ala Ala Gly Ile Leu Lys 
225                 230                 235                 240 


Gln Ala Leu Ala Met Gly Met Met Thr Glu Tyr Tyr His Tyr Ile Phe 
                245                 250                 255     


Thr Thr Leu Asp Leu Phe Ala Leu Asp Val Glu Pro Tyr Arg Tyr Ser 
            260                 265                 270         


Gly Val Asn Met Thr Gly Phe Arg Ile Leu Asn Thr Glu Asn Thr Gln 
        275                 280                 285             


Val Ser Ser Ile Ile Glu Lys Trp Ser Met Glu Arg Leu Gln Ala Pro 
    290                 295                 300                 


Pro Lys Pro Asp Ser Gly Leu Leu Asp Gly Phe Met Thr Thr Asp Ala 
305                 310                 315                 320 


Ala Leu Met Tyr Asp Ala Val His Val Val Ser Val Ala Val Gln Gln 
                325                 330                 335     


Phe Pro Gln Met Thr Val Ser Ser Leu Gln Cys Asn Arg His Lys Pro 
            340                 345                 350         


Trp Arg Phe Gly Thr Arg Phe Met Ser Leu Ile Lys Glu Ala His Trp 
        355                 360                 365             


Glu Gly Leu Thr Gly Arg Ile Thr Phe Asn Lys Thr Asn Gly Leu Arg 
    370                 375                 380                 


Thr Asp Phe Asp Leu Asp Val Ile Ser Leu Lys Glu Glu Gly Leu Glu 
385                 390                 395                 400 


Lys Ile Gly Thr Trp Asp Pro Ala Ser Gly Leu Asn Met Thr Glu Ser 
                405                 410                 415     


Gln Lys Gly Lys Pro Ala Asn Ile Thr Asp Ser Leu Ser Asn Arg Ser 
            420                 425                 430         


Leu Ile Val Thr Thr Ile Leu Glu Glu Pro Tyr Val Leu Phe Lys Lys 
        435                 440                 445             


Ser Asp Lys Pro Leu Tyr Gly Asn Asp Arg Phe Glu Gly Tyr Cys Ile 
    450                 455                 460                 


Asp Leu Leu Arg Glu Leu Ser Thr Ile Leu Gly Phe Thr Tyr Glu Ile 
465                 470                 475                 480 


Arg Leu Val Glu Asp Gly Lys Tyr Gly Ala Gln Asp Asp Ala Asn Gly 
                485                 490                 495     


Gln Trp Asn Gly Met Val Arg Glu Leu Ile Asp His Lys Ala Asp Leu 
            500                 505                 510         


Ala Val Ala Pro Leu Ala Ile Thr Tyr Val Arg Glu Lys Val Ile Asp 
        515                 520                 525             


Phe Ser Lys Pro Phe Met Thr Leu Gly Ile Ser Ile Leu Tyr Arg Lys 
    530                 535                 540                 


Pro Asn Gly Thr Asn Pro Gly Val Phe Ser Phe Leu Asn Pro Leu Ser 
545                 550                 555                 560 


Pro Asp Ile Trp Met Tyr Ile Leu Leu Ala Tyr Leu Gly Val Ser Cys 
                565                 570                 575     


Val Leu Phe Val Ile Ala Arg Phe Ser Pro Tyr Glu Trp Tyr Asn Pro 
            580                 585                 590         


His Pro Cys Asn Pro Asp Ser Asp Val Val Glu Asn Asn Phe Thr Leu 
        595                 600                 605             


Leu Asn Ser Phe Trp Phe Gly Val Gly Ala Leu Met Gln Gln Gly Ser 
    610                 615                 620                 


Glu Leu Met Pro Lys Ala Leu Ser Thr Arg Ile Val Gly Gly Ile Trp 
625                 630                 635                 640 


Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala 
                645                 650                 655     


Ala Phe Leu Thr Val Glu Arg Met Glu Ser Pro Ile Asp Ser Ala Asp 
            660                 665                 670         


Asp Leu Ala Lys Gln Thr Lys Ile Glu Tyr Gly Ala Val Glu Asp Gly 
        675                 680                 685             


Ala Thr Met Thr Phe Phe Lys Lys Ser Lys Ile Ser Thr Tyr Asp Lys 
    690                 695                 700                 


Met Trp Ala Phe Met Ser Ser Arg Arg Gln Ser Val Leu Val Lys Ser 
705                 710                 715                 720 


Asn Glu Glu Gly Ile Gln Arg Val Leu Thr Ser Asp Tyr Ala Phe Leu 
                725                 730                 735     


Met Glu Ser Thr Thr Ile Glu Phe Val Thr Gln Arg Asn Cys Asn Leu 
            740                 745                 750         


Thr Gln Ile Gly Gly Leu Ile Asp Ser Lys Gly Tyr Gly Val Gly Thr 
        755                 760                 765             


Pro Met Gly Ser Pro Tyr Arg Asp Lys Ile Thr Ile Ala Ile Leu Gln 
    770                 775                 780                 


Leu Gln Glu Glu Gly Lys Leu His Met Met Lys Glu Lys Trp Trp Arg 
785                 790                 795                 800 


Gly Asn Gly Cys Pro Glu Glu Glu Ser Lys Glu Ala Ser Ala Leu Gly 
                805                 810                 815     


Val Gln Asn Ile Gly Gly Ile Phe Ile Val Leu Ala Ala Gly Leu Val 
            820                 825                 830         


Leu Ser Val Phe Val Ala Val Gly Glu Phe Leu Tyr Lys Ser Lys Lys 
        835                 840                 845             


Asn Ala Gln Leu Glu Lys Arg Ser Phe Cys Ser Ala Met Val Glu Glu 
    850                 855                 860                 


Leu Arg Met Ser Leu Lys Cys Gln Arg Arg Leu Lys His Lys Pro Gln 
865                 870                 875                 880 


Ala Pro Val Ile Val Lys Thr Glu Glu Val Ile Asn Met His Thr Phe 
                885                 890                 895     


Asn Asp Arg Arg Leu Pro Gly Lys Glu Thr Met Ala 
            900                 905             


<210>  6232
<211>  46
<212>  PRT
<213>  Homo Sapiens

<400>  6232

Ala Asn Leu Ala Ala Phe Met Ile Gln Glu Glu Tyr Val Asp Gln Val 
1               5                   10                  15      


Ser Gly Leu Ser Asp Lys Lys Met Arg Thr Leu Arg Leu Arg Arg Ser 
            20                  25                  30          


Ile Phe Pro Lys Val Thr Lys Leu Val Thr Glu Pro Gly Phe 
        35                  40                  45      


<210>  6233
<211>  35
<212>  PRT
<213>  Homo Sapiens

<400>  6233

Met Lys Pro Arg Ala Glu Cys Cys Ser Pro Lys Phe Trp Leu Val Leu 
1               5                   10                  15      


Ala Val Leu Ala Val Ser Gly Ser Arg Ala Arg Ser Gln Lys Ser Pro 
            20                  25                  30          


Pro Ser Ile 
        35  


<210>  6234
<211>  35
<212>  PRT
<213>  Homo Sapiens

<400>  6234

Met Lys Pro Arg Ala Glu Cys Cys Ser Pro Lys Phe Trp Leu Val Leu 
1               5                   10                  15      


Ala Val Leu Ala Val Ser Gly Ser Arg Ala Arg Ser Gln Lys Ser Pro 
            20                  25                  30          


Pro Ser Ile 
        35  


<210>  6235
<211>  1484
<212>  PRT
<213>  Homo Sapiens

<400>  6235

Met Lys Pro Arg Ala Glu Cys Cys Ser Pro Lys Phe Trp Leu Val Leu 
1               5                   10                  15      


Ala Val Leu Ala Val Ser Gly Ser Arg Ala Arg Ser Gln Lys Ser Pro 
            20                  25                  30          


Pro Ser Ile Gly Ile Ala Val Ile Leu Val Gly Thr Ser Asp Glu Val 
        35                  40                  45              


Ala Ile Lys Asp Ala His Glu Lys Asp Asp Phe His His Leu Ser Val 
    50                  55                  60                  


Val Pro Arg Val Glu Leu Val Ala Met Asn Glu Thr Asp Pro Lys Ser 
65                  70                  75                  80  


Ile Ile Thr Arg Ile Cys Asp Leu Met Ser Asp Arg Lys Ile Gln Gly 
                85                  90                  95      


Val Val Phe Ala Asp Asp Thr Asp Gln Glu Ala Ile Ala Gln Ile Leu 
            100                 105                 110         


Asp Phe Ile Ser Ala Gln Thr Leu Thr Pro Ile Leu Gly Ile His Gly 
        115                 120                 125             


Gly Ser Ser Met Ile Met Ala Asp Lys Asp Glu Ser Ser Met Phe Phe 
    130                 135                 140                 


Gln Phe Gly Pro Ser Ile Glu Gln Gln Ala Ser Val Met Leu Asn Ile 
145                 150                 155                 160 


Met Glu Glu Tyr Asp Trp Tyr Ile Phe Ser Ile Val Thr Thr Tyr Phe 
                165                 170                 175     


Pro Gly Tyr Gln Asp Phe Val Asn Lys Ile Arg Ser Thr Ile Glu Asn 
            180                 185                 190         


Ser Phe Val Gly Trp Glu Leu Glu Glu Val Leu Leu Leu Asp Met Ser 
        195                 200                 205             


Leu Asp Asp Gly Asp Ser Lys Ile Gln Asn Gln Leu Lys Lys Leu Gln 
    210                 215                 220                 


Ser Pro Ile Ile Leu Leu Tyr Cys Thr Lys Glu Glu Ala Thr Tyr Ile 
225                 230                 235                 240 


Phe Glu Val Ala Asn Ser Val Gly Leu Thr Gly Tyr Gly Tyr Thr Trp 
                245                 250                 255     


Ile Val Pro Ser Leu Val Ala Gly Asp Thr Asp Thr Val Pro Ala Glu 
            260                 265                 270         


Phe Pro Thr Gly Leu Ile Ser Val Ser Tyr Asp Glu Trp Asp Tyr Gly 
        275                 280                 285             


Leu Pro Ala Arg Val Arg Asp Gly Ile Ala Ile Ile Thr Thr Ala Ala 
    290                 295                 300                 


Ser Asp Met Leu Ser Glu His Ser Phe Ile Pro Glu Pro Lys Ser Ser 
305                 310                 315                 320 


Cys Tyr Asn Thr His Glu Lys Arg Ile Tyr Gln Ser Asn Met Leu Asn 
                325                 330                 335     


Arg Tyr Leu Ile Asn Val Thr Phe Glu Gly Arg Asn Leu Ser Phe Ser 
            340                 345                 350         


Glu Asp Gly Tyr Gln Met His Pro Lys Leu Val Ile Ile Leu Leu Asn 
        355                 360                 365             


Lys Glu Arg Lys Trp Glu Arg Val Gly Lys Trp Lys Asp Lys Ser Leu 
    370                 375                 380                 


Gln Met Lys Tyr Tyr Val Trp Pro Arg Met Cys Pro Glu Thr Glu Glu 
385                 390                 395                 400 


Gln Glu Asp Asp His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe 
                405                 410                 415     


Val Ile Val Glu Ser Val Asp Pro Leu Ser Gly Thr Cys Met Arg Asn 
            420                 425                 430         


Thr Val Pro Cys Gln Lys Arg Ile Val Thr Glu Asn Lys Thr Asp Glu 
        435                 440                 445             


Glu Pro Gly Tyr Ile Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile 
    450                 455                 460                 


Leu Lys Lys Ile Ser Lys Ser Val Lys Phe Thr Tyr Asp Leu Tyr Leu 
465                 470                 475                 480 


Val Thr Asn Gly Lys His Gly Lys Lys Ile Asn Gly Thr Trp Asn Gly 
                485                 490                 495     


Met Ile Gly Glu Val Val Met Lys Arg Ala Tyr Met Ala Val Gly Ser 
            500                 505                 510         


Leu Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro 
        515                 520                 525             


Phe Ile Glu Thr Gly Ile Ser Val Met Val Ser Arg Ser Asn Gly Thr 
    530                 535                 540                 


Val Ser Pro Ser Ala Phe Leu Glu Pro Phe Ser Ala Asp Val Trp Val 
545                 550                 555                 560 


Met Met Phe Val Met Leu Leu Ile Val Ser Ala Val Ala Val Phe Val 
                565                 570                 575     


Phe Glu Tyr Phe Ser Pro Val Gly Tyr Asn Arg Cys Leu Ala Asp Gly 
            580                 585                 590         


Arg Glu Pro Gly Gly Pro Ser Phe Thr Ile Gly Lys Ala Ile Trp Leu 
        595                 600                 605             


Leu Trp Gly Leu Val Phe Asn Asn Ser Val Pro Val Gln Asn Pro Lys 
    610                 615                 620                 


Gly Thr Thr Ser Lys Ile Met Val Ser Val Trp Ala Phe Phe Ala Val 
625                 630                 635                 640 


Ile Phe Leu Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln 
                645                 650                 655     


Glu Glu Tyr Val Asp Gln Val Ser Gly Leu Ser Asp Lys Lys Phe Gln 
            660                 665                 670         


Arg Pro Asn Asp Phe Ser Pro Pro Phe Arg Phe Gly Thr Val Pro Asn 
        675                 680                 685             


Gly Ser Thr Glu Arg Asn Ile Arg Asn Asn Tyr Ala Glu Met His Ala 
    690                 695                 700                 


Tyr Met Gly Lys Phe Asn Gln Arg Gly Val Asp Asp Ala Leu Leu Ser 
705                 710                 715                 720 


Leu Lys Thr Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu 
                725                 730                 735     


Asn Tyr Met Ala Gly Arg Asp Glu Gly Cys Lys Leu Val Thr Ile Gly 
            740                 745                 750         


Ser Gly Lys Val Phe Ala Ser Thr Gly Tyr Gly Ile Ala Ile Gln Lys 
        755                 760                 765             


Asp Ser Gly Trp Lys Arg Gln Val Asp Leu Ala Ile Leu Gln Leu Phe 
    770                 775                 780                 


Gly Asp Gly Glu Met Glu Glu Leu Glu Ala Leu Trp Leu Thr Gly Ile 
785                 790                 795                 800 


Cys His Asn Glu Lys Asn Glu Val Met Ser Ser Gln Leu Asp Ile Asp 
                805                 810                 815     


Asn Met Ala Gly Val Phe Tyr Met Leu Gly Ala Ala Met Ala Leu Ser 
            820                 825                 830         


Leu Ile Thr Phe Ile Cys Glu His Leu Phe Tyr Trp Gln Phe Arg His 
        835                 840                 845             


Cys Phe Met Gly Val Cys Ser Gly Lys Pro Gly Met Val Phe Ser Ile 
    850                 855                 860                 


Ser Arg Gly Ile Tyr Ser Cys Ile His Gly Val Ala Ile Glu Glu Arg 
865                 870                 875                 880 


Gln Ser Val Met Asn Ser Pro Thr Ala Thr Met Asn Asn Thr His Ser 
                885                 890                 895     


Asn Ile Leu Arg Leu Leu Arg Thr Ala Lys Asn Met Ala Asn Leu Ser 
            900                 905                 910         


Gly Val Asn Gly Ser Pro Gln Ser Ala Leu Asp Phe Ile Arg Arg Glu 
        915                 920                 925             


Ser Ser Val Tyr Asp Ile Ser Glu His Arg Arg Ser Phe Thr His Ser 
    930                 935                 940                 


Asp Cys Lys Ser Tyr Asn Asn Pro Pro Cys Glu Glu Asn Leu Phe Ser 
945                 950                 955                 960 


Asp Tyr Ile Ser Glu Val Glu Arg Thr Phe Gly Asn Leu Gln Leu Lys 
                965                 970                 975     


Asp Ser Asn Val Tyr Gln Asp His Tyr His His His His Arg Pro His 
            980                 985                 990         


Ser Ile Gly Ser Ala Ser Ser Ile  Asp Gly Leu Tyr Asp  Cys Asp Asn 
        995                 1000                 1005             


Pro Pro  Phe Thr Thr Gln Ser  Arg Ser Ile Ser Lys  Lys Pro Leu 
    1010                 1015                 1020             


Asp Ile  Gly Leu Pro Ser Ser  Lys His Ser Gln Leu  Ser Asp Leu 
    1025                 1030                 1035             


Tyr Gly  Lys Phe Ser Phe Lys  Ser Asp Arg Tyr Ser  Gly His Asp 
    1040                 1045                 1050             


Asp Leu  Ile Arg Ser Asp Val  Ser Asp Ile Ser Thr  His Thr Val 
    1055                 1060                 1065             


Thr Tyr  Gly Asn Ile Glu Gly  Asn Ala Ala Lys Arg  Arg Lys Gln 
    1070                 1075                 1080             


Gln Tyr  Lys Asp Ser Leu Lys  Lys Arg Pro Ala Ser  Ala Lys Ser 
    1085                 1090                 1095             


Arg Arg  Glu Phe Asp Glu Ile  Glu Leu Ala Tyr Arg  Arg Arg Pro 
    1100                 1105                 1110             


Pro Arg  Ser Pro Asp His Lys  Arg Tyr Phe Arg Asp  Lys Glu Gly 
    1115                 1120                 1125             


Leu Arg  Asp Phe Tyr Leu Asp  Gln Phe Arg Thr Lys  Glu Asn Ser 
    1130                 1135                 1140             


Pro His  Trp Glu His Val Asp  Leu Thr Asp Ile Tyr  Lys Glu Arg 
    1145                 1150                 1155             


Ser Asp  Asp Phe Lys Arg Asp  Ser Val Ser Gly Gly  Gly Pro Cys 
    1160                 1165                 1170             


Thr Asn  Arg Ser His Ile Lys  His Gly Thr Gly Asp  Lys His Gly 
    1175                 1180                 1185             


Val Val  Ser Gly Val Pro Ala  Pro Trp Glu Lys Asn  Leu Thr Asn 
    1190                 1195                 1200             


Val Glu  Trp Glu Asp Arg Ser  Gly Gly Asn Phe Cys  Arg Ser Cys 
    1205                 1210                 1215             


Pro Ser  Lys Leu His Asn Tyr  Ser Thr Thr Val Thr  Gly Gln Asn 
    1220                 1225                 1230             


Ser Gly  Arg Gln Ala Cys Ile  Arg Cys Glu Ala Cys  Lys Lys Ala 
    1235                 1240                 1245             


Gly Asn  Leu Tyr Asp Ile Ser  Glu Asp Asn Ser Leu  Gln Glu Leu 
    1250                 1255                 1260             


Asp Gln  Pro Ala Ala Pro Val  Ala Val Thr Ser Asn  Ala Ser Thr 
    1265                 1270                 1275             


Thr Lys  Tyr Pro Gln Ser Pro  Thr Asn Ser Lys Ala  Gln Lys Lys 
    1280                 1285                 1290             


Asn Arg  Asn Lys Leu Arg Arg  Gln His Ser Tyr Asp  Thr Phe Val 
    1295                 1300                 1305             


Asp Leu  Gln Lys Glu Glu Ala  Ala Leu Ala Pro Arg  Ser Val Ser 
    1310                 1315                 1320             


Leu Lys  Asp Lys Gly Arg Phe  Met Asp Gly Ser Pro  Tyr Ala His 
    1325                 1330                 1335             


Met Phe  Glu Met Ser Ala Gly  Glu Ser Thr Phe Ala  Asn Asn Lys 
    1340                 1345                 1350             


Ser Ser  Val Pro Thr Ala Gly  His His His His Asn  Asn Pro Gly 
    1355                 1360                 1365             


Gly Gly  Tyr Met Leu Ser Lys  Ser Leu Tyr Pro Asp  Arg Val Thr 
    1370                 1375                 1380             


Gln Asn  Pro Phe Ile Pro Thr  Phe Gly Asp Asp Gln  Cys Leu Leu 
    1385                 1390                 1395             


His Gly  Ser Lys Ser Tyr Phe  Phe Arg Gln Pro Thr  Val Ala Gly 
    1400                 1405                 1410             


Ala Ser  Lys Ala Arg Pro Asp  Phe Arg Ala Leu Val  Thr Asn Lys 
    1415                 1420                 1425             


Pro Val  Val Ser Ala Leu His  Gly Ala Val Pro Ala  Arg Phe Gln 
    1430                 1435                 1440             


Lys Asp  Ile Cys Ile Gly Asn  Gln Ser Asn Pro Cys  Val Pro Asn 
    1445                 1450                 1455             


Asn Lys  Asn Pro Arg Ala Phe  Asn Gly Ser Ser Asn  Gly His Val 
    1460                 1465                 1470             


Tyr Glu  Lys Leu Ser Ser Ile  Glu Ser Asp Val 
    1475                 1480                 


<210>  6236
<211>  70
<212>  PRT
<213>  Homo Sapiens

<400>  6236

Met Gly Ser Leu Leu Ala Leu Leu Ala Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Glu Gly Pro Ala Lys Lys Val Leu Thr Leu Glu Gly Asp Leu 
            20                  25                  30          


Val Leu Gly Gly Leu Phe Pro Val His Gln Lys Gly Gly Pro Ala Glu 
        35                  40                  45              


Asp Cys Gly Pro Val Asn Glu His Arg Gly Ile Gln Arg Leu Glu Ala 
    50                  55                  60                  


Met Leu Phe Ala Leu Asp 
65                  70  


<210>  6237
<211>  435
<212>  PRT
<213>  Homo Sapiens

<400>  6237

Met Gly Ser Leu Leu Ala Leu Leu Ala Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Glu Gly Pro Ala Lys Lys Val Leu Thr Leu Glu Gly Asp Leu 
            20                  25                  30          


Val Leu Gly Gly Leu Phe Pro Val His Gln Lys Gly Gly Pro Ala Glu 
        35                  40                  45              


Asp Cys Gly Pro Val Asn Glu His Arg Gly Ile Gln Arg Leu Glu Ala 
    50                  55                  60                  


Met Leu Phe Ala Leu Asp Arg Ile Asn Arg Asp Pro His Leu Leu Pro 
65                  70                  75                  80  


Gly Val Arg Leu Gly Ala His Ile Leu Asp Ser Cys Ser Lys Asp Thr 
                85                  90                  95      


His Ala Leu Glu Gln Ala Leu Asp Phe Val Arg Ala Ser Leu Ser Arg 
            100                 105                 110         


Gly Ala Asp Gly Ser Arg His Ile Cys Pro Asp Gly Ser Tyr Ala Thr 
        115                 120                 125             


His Gly Asp Ala Pro Thr Ala Ile Thr Gly Val Ile Gly Gly Ser Tyr 
    130                 135                 140                 


Ser Asp Val Ser Ile Gln Val Ala Asn Leu Leu Arg Leu Phe Gln Ile 
145                 150                 155                 160 


Pro Gln Ile Ser Tyr Ala Ser Thr Ser Ala Lys Leu Ser Asp Lys Ser 
                165                 170                 175     


Arg Tyr Asp Tyr Phe Ala Arg Thr Val Pro Pro Asp Phe Phe Gln Ala 
            180                 185                 190         


Lys Ala Met Ala Glu Ile Leu Arg Phe Phe Asn Trp Thr Tyr Val Ser 
        195                 200                 205             


Thr Val Ala Ser Glu Gly Asp Tyr Gly Glu Thr Gly Ile Glu Ala Phe 
    210                 215                 220                 


Glu Leu Glu Ala Arg Ala Arg Asn Ile Cys Val Ala Thr Ser Glu Lys 
225                 230                 235                 240 


Val Gly Arg Ala Met Ser Arg Ala Ala Phe Glu Gly Val Val Arg Ala 
                245                 250                 255     


Leu Leu Gln Lys Pro Ser Ala Arg Val Ala Val Leu Phe Thr Arg Ser 
            260                 265                 270         


Glu Asp Ala Arg Glu Leu Leu Ala Ala Ser Gln Arg Leu Asn Ala Ser 
        275                 280                 285             


Phe Thr Trp Val Ala Ser Asp Gly Trp Gly Ala Leu Glu Ser Val Val 
    290                 295                 300                 


Ala Gly Ser Glu Gly Ala Ala Glu Gly Ala Ile Thr Ile Glu Leu Ala 
305                 310                 315                 320 


Ser Tyr Pro Ile Ser Asp Phe Ala Ser Tyr Phe Gln Ser Leu Asp Pro 
                325                 330                 335     


Trp Asn Asn Ser Arg Asn Pro Trp Phe Arg Glu Phe Trp Glu Gln Arg 
            340                 345                 350         


Phe Arg Cys Ser Phe Arg Gln Arg Asp Cys Ala Ala His Ser Leu Arg 
        355                 360                 365             


Ala Val Pro Phe Glu Gln Glu Ser Lys Ile Met Phe Val Val Asn Ala 
    370                 375                 380                 


Val Tyr Ala Met Ala His Ala Leu His Asn Met His Arg Ala Leu Cys 
385                 390                 395                 400 


Pro Asn Thr Thr Arg Leu Cys Asp Ala Met Arg Pro Val Asn Gly Arg 
                405                 410                 415     


Arg Leu Tyr Lys Asp Phe Val Leu Asn Val Lys Phe Asp Gly Asp Leu 
            420                 425                 430         


Lys Val Ser 
        435 


<210>  6238
<211>  872
<212>  PRT
<213>  Homo Sapiens

<400>  6238

Met Gly Ser Leu Leu Ala Leu Leu Ala Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Glu Gly Pro Ala Lys Lys Val Leu Thr Leu Glu Gly Asp Leu 
            20                  25                  30          


Val Leu Gly Gly Leu Phe Pro Val His Gln Lys Gly Gly Pro Ala Glu 
        35                  40                  45              


Asp Cys Gly Pro Val Asn Glu His Arg Gly Ile Gln Arg Leu Glu Ala 
    50                  55                  60                  


Met Leu Phe Ala Leu Asp Arg Ile Asn Arg Asp Pro His Leu Leu Pro 
65                  70                  75                  80  


Gly Val Arg Leu Gly Ala His Ile Leu Asp Ser Cys Ser Lys Asp Thr 
                85                  90                  95      


His Ala Leu Glu Gln Ala Leu Asp Phe Val Arg Ala Ser Leu Ser Arg 
            100                 105                 110         


Gly Ala Asp Gly Ser Arg His Ile Cys Pro Asp Gly Ser Tyr Ala Thr 
        115                 120                 125             


His Gly Asp Ala Pro Thr Ala Ile Thr Gly Val Ile Gly Gly Ser Tyr 
    130                 135                 140                 


Ser Asp Val Ser Ile Gln Val Ala Asn Leu Leu Arg Leu Phe Gln Ile 
145                 150                 155                 160 


Pro Gln Ile Ser Tyr Ala Ser Thr Ser Ala Lys Leu Ser Asp Lys Ser 
                165                 170                 175     


Arg Tyr Asp Tyr Phe Ala Arg Thr Val Pro Pro Asp Phe Phe Gln Ala 
            180                 185                 190         


Lys Ala Met Ala Glu Ile Leu Arg Phe Phe Asn Trp Thr Tyr Val Ser 
        195                 200                 205             


Thr Val Ala Ser Glu Gly Asp Tyr Gly Glu Thr Gly Ile Glu Ala Phe 
    210                 215                 220                 


Glu Leu Glu Ala Arg Ala Arg Asn Ile Cys Val Ala Thr Ser Glu Lys 
225                 230                 235                 240 


Val Gly Arg Ala Met Ser Arg Ala Ala Phe Glu Gly Val Val Arg Ala 
                245                 250                 255     


Leu Leu Gln Lys Pro Ser Ala Arg Val Ala Val Leu Phe Thr Arg Ser 
            260                 265                 270         


Glu Asp Ala Arg Glu Leu Leu Ala Ala Ser Gln Arg Leu Asn Ala Ser 
        275                 280                 285             


Phe Thr Trp Val Ala Ser Asp Gly Trp Gly Ala Leu Glu Ser Val Val 
    290                 295                 300                 


Ala Gly Ser Glu Gly Ala Ala Glu Gly Ala Ile Thr Ile Glu Leu Ala 
305                 310                 315                 320 


Ser Tyr Pro Ile Ser Asp Phe Ala Ser Tyr Phe Gln Ser Leu Asp Pro 
                325                 330                 335     


Trp Asn Asn Ser Arg Asn Pro Trp Phe Arg Glu Phe Trp Glu Gln Arg 
            340                 345                 350         


Phe Arg Cys Ser Phe Arg Gln Arg Asp Cys Ala Ala His Ser Leu Arg 
        355                 360                 365             


Ala Val Pro Phe Glu Gln Glu Ser Lys Ile Met Phe Val Val Asn Ala 
    370                 375                 380                 


Val Tyr Ala Met Ala His Ala Leu His Asn Met His Arg Ala Leu Cys 
385                 390                 395                 400 


Pro Asn Thr Thr Arg Leu Cys Asp Ala Met Arg Pro Val Asn Gly Arg 
                405                 410                 415     


Arg Leu Tyr Lys Asp Phe Val Leu Asn Val Lys Phe Asp Ala Pro Phe 
            420                 425                 430         


Arg Pro Ala Asp Thr His Asn Glu Val Arg Phe Asp Arg Phe Gly Asp 
        435                 440                 445             


Gly Ile Gly Arg Tyr Asn Ile Phe Thr Tyr Leu Arg Ala Gly Ser Gly 
    450                 455                 460                 


Arg Tyr Arg Tyr Gln Lys Val Gly Tyr Trp Ala Glu Gly Leu Thr Leu 
465                 470                 475                 480 


Asp Thr Ser Leu Ile Pro Trp Ala Ser Pro Ser Ala Gly Pro Leu Pro 
                485                 490                 495     


Ala Ser Arg Cys Ser Glu Pro Cys Leu Gln Asn Glu Val Lys Ser Val 
            500                 505                 510         


Gln Pro Gly Glu Val Cys Cys Trp Leu Cys Ile Pro Cys Gln Pro Tyr 
        515                 520                 525             


Glu Tyr Arg Leu Asp Glu Phe Thr Cys Ala Asp Cys Gly Leu Gly Tyr 
    530                 535                 540                 


Trp Pro Asn Ala Ser Leu Thr Gly Cys Phe Glu Leu Pro Gln Glu Tyr 
545                 550                 555                 560 


Ile Arg Trp Gly Asp Ala Trp Ala Val Gly Pro Val Thr Ile Ala Cys 
                565                 570                 575     


Leu Gly Ala Leu Ala Thr Leu Phe Val Leu Gly Val Phe Val Arg His 
            580                 585                 590         


Asn Ala Thr Pro Val Val Lys Ala Ser Gly Arg Glu Leu Cys Tyr Ile 
        595                 600                 605             


Leu Leu Gly Gly Val Phe Leu Cys Tyr Cys Met Thr Phe Ile Phe Ile 
    610                 615                 620                 


Ala Lys Pro Ser Thr Ala Val Cys Thr Leu Arg Arg Leu Gly Leu Gly 
625                 630                 635                 640 


Thr Ala Phe Ser Val Cys Tyr Ser Ala Leu Leu Thr Lys Thr Asn Arg 
                645                 650                 655     


Ile Ala Arg Ile Phe Gly Gly Ala Arg Glu Gly Ala Gln Arg Pro Arg 
            660                 665                 670         


Phe Ile Ser Pro Ala Ser Gln Val Ala Ile Cys Leu Ala Leu Ile Ser 
        675                 680                 685             


Gly Gln Leu Leu Ile Val Val Ala Trp Leu Val Val Glu Ala Pro Gly 
    690                 695                 700                 


Thr Gly Lys Glu Thr Ala Pro Glu Arg Arg Glu Val Val Thr Leu Arg 
705                 710                 715                 720 


Cys Asn His Arg Asp Ala Ser Met Leu Gly Ser Leu Ala Tyr Asn Val 
                725                 730                 735     


Leu Leu Ile Ala Leu Cys Thr Leu Tyr Ala Phe Lys Thr Arg Lys Cys 
            740                 745                 750         


Pro Glu Asn Phe Asn Glu Ala Lys Phe Ile Gly Phe Thr Met Tyr Thr 
        755                 760                 765             


Thr Cys Ile Ile Trp Leu Ala Phe Leu Pro Ile Phe Tyr Val Thr Ser 
    770                 775                 780                 


Ser Asp Tyr Arg Val Gln Thr Thr Thr Met Cys Val Ser Val Ser Leu 
785                 790                 795                 800 


Ser Gly Ser Val Val Leu Gly Cys Leu Phe Ala Pro Lys Leu His Ile 
                805                 810                 815     


Ile Leu Phe Gln Pro Gln Lys Asn Val Val Ser His Arg Ala Pro Thr 
            820                 825                 830         


Ser Arg Phe Gly Ser Ala Ala Ala Arg Ala Ser Ser Ser Leu Gly Gln 
        835                 840                 845             


Gly Ser Gly Ser Gln Phe Val Pro Thr Val Cys Asn Gly Arg Glu Val 
    850                 855                 860                 


Val Asp Ser Thr Thr Ser Ser Leu 
865                 870         


<210>  6239
<211>  594
<212>  PRT
<213>  Homo Sapiens

<400>  6239

Met Gly Ser Leu Leu Ala Leu Leu Ala Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Glu Gly Pro Ala Lys Lys Val Leu Thr Leu Glu Gly Asp Leu 
            20                  25                  30          


Val Leu Gly Gly Leu Phe Pro Val His Gln Lys Gly Gly Pro Ala Glu 
        35                  40                  45              


Asp Cys Gly Pro Val Asn Glu His Arg Gly Ile Gln Arg Leu Glu Ala 
    50                  55                  60                  


Met Leu Phe Ala Leu Asp Arg Ile Asn Arg Asp Pro His Leu Leu Pro 
65                  70                  75                  80  


Gly Val Arg Leu Gly Ala His Ile Leu Asp Ser Cys Ser Lys Asp Thr 
                85                  90                  95      


His Ala Leu Glu Gln Ala Leu Asp Phe Val Arg Ala Ser Leu Ser Arg 
            100                 105                 110         


Gly Ala Asp Gly Ser Arg His Ile Cys Pro Asp Gly Ser Tyr Ala Thr 
        115                 120                 125             


His Gly Asp Ala Pro Thr Ala Ile Thr Gly Val Ile Gly Gly Ser Tyr 
    130                 135                 140                 


Ser Asp Val Ser Ile Gln Val Ala Asn Leu Leu Arg Leu Phe Gln Ile 
145                 150                 155                 160 


Pro Gln Ile Ser Tyr Ala Ser Thr Ser Ala Lys Leu Ser Asp Lys Ser 
                165                 170                 175     


Arg Tyr Asp Tyr Phe Ala Arg Thr Val Pro Pro Asp Phe Phe Gln Ala 
            180                 185                 190         


Lys Ala Met Ala Glu Ile Leu Arg Phe Phe Asn Trp Thr Tyr Val Ser 
        195                 200                 205             


Thr Val Ala Ser Glu Gly Asp Tyr Gly Glu Thr Gly Ile Glu Ala Phe 
    210                 215                 220                 


Glu Leu Glu Ala Arg Ala Arg Asn Ile Cys Val Ala Thr Ser Glu Lys 
225                 230                 235                 240 


Val Gly Arg Ala Met Ser Arg Ala Ala Phe Glu Gly Val Val Arg Ala 
                245                 250                 255     


Leu Leu Gln Lys Pro Ser Ala Arg Val Ala Val Leu Phe Thr Arg Ser 
            260                 265                 270         


Glu Asp Ala Arg Glu Leu Leu Ala Ala Ser Gln Arg Leu Asn Ala Ser 
        275                 280                 285             


Phe Thr Trp Val Ala Ser Asp Gly Trp Gly Ala Leu Glu Ser Val Val 
    290                 295                 300                 


Ala Gly Ser Glu Gly Ala Ala Glu Gly Ala Ile Thr Ile Glu Leu Ala 
305                 310                 315                 320 


Ser Tyr Pro Ile Ser Asp Phe Ala Ser Tyr Phe Gln Ser Leu Asp Pro 
                325                 330                 335     


Trp Asn Asn Ser Arg Asn Pro Trp Phe Arg Glu Phe Trp Glu Gln Arg 
            340                 345                 350         


Phe Arg Cys Ser Phe Arg Gln Arg Asp Cys Ala Ala His Ser Leu Arg 
        355                 360                 365             


Ala Val Pro Phe Glu Gln Glu Ser Lys Ile Met Phe Val Val Asn Ala 
    370                 375                 380                 


Val Tyr Ala Met Ala His Ala Leu His Asn Met His Arg Ala Leu Cys 
385                 390                 395                 400 


Pro Asn Thr Thr Arg Leu Cys Asp Ala Met Arg Pro Val Asn Gly Arg 
                405                 410                 415     


Arg Leu Tyr Lys Asp Phe Val Leu Asn Val Lys Phe Asp Ala Pro Phe 
            420                 425                 430         


Arg Pro Ala Asp Thr His Asn Glu Val Arg Phe Asp Arg Phe Gly Asp 
        435                 440                 445             


Gly Ile Gly Arg Tyr Asn Ile Phe Thr Tyr Leu Arg Ala Gly Ser Gly 
    450                 455                 460                 


Arg Tyr Arg Tyr Gln Lys Thr Arg Lys Cys Pro Glu Asn Phe Asn Glu 
465                 470                 475                 480 


Ala Lys Phe Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Ile Trp Leu 
                485                 490                 495     


Ala Phe Leu Pro Ile Phe Tyr Val Thr Ser Ser Asp Tyr Arg Val Gln 
            500                 505                 510         


Thr Thr Thr Met Cys Val Ser Val Ser Leu Ser Gly Ser Val Val Leu 
        515                 520                 525             


Gly Cys Leu Phe Ala Pro Lys Leu His Ile Ile Leu Phe Gln Pro Gln 
    530                 535                 540                 


Lys Asn Val Val Ser His Arg Ala Pro Thr Ser Arg Phe Gly Ser Ala 
545                 550                 555                 560 


Ala Ala Arg Ala Ser Ser Ser Leu Gly Gln Gly Ser Gly Ser Gln Phe 
                565                 570                 575     


Val Pro Thr Val Cys Asn Gly Arg Glu Val Val Asp Ser Thr Thr Ser 
            580                 585                 590         


Ser Leu 
        


<210>  6240
<211>  81
<212>  PRT
<213>  Homo Sapiens

<400>  6240

Met Lys Met Leu Thr Arg Leu Gln Val Leu Thr Leu Ala Leu Phe Ser 
1               5                   10                  15      


Lys Gly Phe Leu Leu Ser Leu Gly Asp His Asn Phe Leu Arg Arg Glu 
            20                  25                  30          


Ile Lys Ile Glu Gly Asp Leu Val Leu Gly Gly Leu Phe Pro Ile Asn 
        35                  40                  45              


Glu Lys Gly Thr Gly Thr Glu Glu Cys Gly Arg Ile Asn Glu Asp Arg 
    50                  55                  60                  


Gly Ile Gln Arg Leu Glu Ala Met Leu Phe Ala Ile Asp Glu Ile Asn 
65                  70                  75                  80  


Lys 
    


<210>  6241
<211>  87
<212>  PRT
<213>  Homo Sapiens

<400>  6241

Met Lys Met Leu Thr Arg Leu Gln Val Leu Thr Leu Ala Leu Phe Ser 
1               5                   10                  15      


Lys Gly Phe Leu Leu Ser Leu Gly Asp His Asn Phe Leu Arg Arg Glu 
            20                  25                  30          


Ile Lys Ile Glu Gly Asp Leu Val Leu Gly Gly Leu Phe Pro Ile Asn 
        35                  40                  45              


Glu Lys Gly Thr Gly Thr Glu Glu Cys Gly Arg Ile Asn Glu Asp Arg 
    50                  55                  60                  


Gly Ile Gln Arg Leu Glu Ala Met Leu Phe Ala Ile Asp Glu Ile Asn 
65                  70                  75                  80  


Lys Asp Asp Tyr Leu Leu Pro 
                85          


<210>  6242
<211>  879
<212>  PRT
<213>  Homo Sapiens

<400>  6242

Met Lys Met Leu Thr Arg Leu Gln Val Leu Thr Leu Ala Leu Phe Ser 
1               5                   10                  15      


Lys Gly Phe Leu Leu Ser Leu Gly Asp His Asn Phe Leu Arg Arg Glu 
            20                  25                  30          


Ile Lys Ile Glu Gly Asp Leu Val Leu Gly Gly Leu Phe Pro Ile Asn 
        35                  40                  45              


Glu Lys Gly Thr Gly Thr Glu Glu Cys Gly Arg Ile Asn Glu Asp Arg 
    50                  55                  60                  


Gly Ile Gln Arg Leu Glu Ala Met Leu Phe Ala Ile Asp Glu Ile Asn 
65                  70                  75                  80  


Lys Asp Asp Tyr Leu Leu Pro Gly Val Lys Leu Gly Val His Ile Leu 
                85                  90                  95      


Asp Thr Cys Ser Arg Asp Thr Tyr Ala Leu Glu Gln Ser Leu Glu Phe 
            100                 105                 110         


Val Arg Ala Ser Leu Thr Lys Val Asp Glu Ala Glu Tyr Met Cys Pro 
        115                 120                 125             


Asp Gly Ser Tyr Ala Ile Gln Glu Asn Ile Pro Leu Leu Ile Ala Gly 
    130                 135                 140                 


Val Ile Gly Gly Ser Tyr Ser Ser Val Ser Ile Gln Val Ala Asn Leu 
145                 150                 155                 160 


Leu Arg Leu Phe Gln Ile Pro Gln Ile Ser Tyr Ala Ser Thr Ser Ala 
                165                 170                 175     


Lys Leu Ser Asp Lys Ser Arg Tyr Asp Tyr Phe Ala Arg Thr Val Pro 
            180                 185                 190         


Pro Asp Phe Tyr Gln Ala Lys Ala Met Ala Glu Ile Leu Arg Phe Phe 
        195                 200                 205             


Asn Trp Thr Tyr Val Ser Thr Val Ala Ser Glu Gly Asp Tyr Gly Glu 
    210                 215                 220                 


Thr Gly Ile Glu Ala Phe Glu Gln Glu Ala Arg Leu Arg Asn Ile Cys 
225                 230                 235                 240 


Ile Ala Thr Ala Glu Lys Val Gly Arg Ser Asn Ile Arg Lys Ser Tyr 
                245                 250                 255     


Asp Ser Val Ile Arg Glu Leu Leu Gln Lys Pro Asn Ala Arg Val Val 
            260                 265                 270         


Val Leu Phe Met Arg Ser Asp Asp Ser Arg Glu Leu Ile Ala Ala Ala 
        275                 280                 285             


Ser Arg Ala Asn Ala Ser Phe Thr Trp Val Ala Ser Asp Gly Trp Gly 
    290                 295                 300                 


Ala Gln Glu Ser Ile Ile Lys Gly Ser Glu His Val Ala Tyr Gly Ala 
305                 310                 315                 320 


Ile Thr Leu Glu Leu Ala Ser Gln Pro Val Arg Gln Phe Asp Arg Tyr 
                325                 330                 335     


Phe Gln Ser Leu Asn Pro Tyr Asn Asn His Arg Asn Pro Trp Phe Arg 
            340                 345                 350         


Asp Phe Trp Glu Gln Lys Phe Gln Cys Ser Leu Gln Asn Lys Arg Asn 
        355                 360                 365             


His Arg Arg Val Cys Asp Lys His Leu Ala Ile Asp Ser Ser Asn Tyr 
    370                 375                 380                 


Glu Gln Glu Ser Lys Ile Met Phe Val Val Asn Ala Val Tyr Ala Met 
385                 390                 395                 400 


Ala His Ala Leu His Lys Met Gln Arg Thr Leu Cys Pro Asn Thr Thr 
                405                 410                 415     


Lys Leu Cys Asp Ala Met Lys Ile Leu Asp Gly Lys Lys Leu Tyr Lys 
            420                 425                 430         


Asp Tyr Leu Leu Lys Ile Asn Phe Thr Ala Pro Phe Asn Pro Asn Lys 
        435                 440                 445             


Asp Ala Asp Ser Ile Val Lys Phe Asp Thr Phe Gly Asp Gly Met Gly 
    450                 455                 460                 


Arg Tyr Asn Val Phe Asn Phe Gln Asn Val Gly Gly Lys Tyr Ser Tyr 
465                 470                 475                 480 


Leu Lys Val Gly His Trp Ala Glu Thr Leu Ser Leu Asp Val Asn Ser 
                485                 490                 495     


Ile His Trp Ser Arg Asn Ser Val Pro Thr Ser Gln Cys Ser Asp Pro 
            500                 505                 510         


Cys Ala Pro Asn Glu Met Lys Asn Met Gln Pro Gly Asp Val Cys Cys 
        515                 520                 525             


Trp Ile Cys Ile Pro Cys Glu Pro Tyr Glu Tyr Leu Ala Asp Glu Phe 
    530                 535                 540                 


Thr Cys Met Asp Cys Gly Ser Gly Gln Trp Pro Thr Ala Asp Leu Thr 
545                 550                 555                 560 


Gly Cys Tyr Asp Leu Pro Glu Asp Tyr Ile Arg Trp Glu Asp Ala Trp 
                565                 570                 575     


Ala Ile Gly Pro Val Thr Ile Ala Cys Leu Gly Phe Met Cys Thr Cys 
            580                 585                 590         


Met Val Val Thr Val Phe Ile Lys His Asn Asn Thr Pro Leu Val Lys 
        595                 600                 605             


Ala Ser Gly Arg Glu Leu Cys Tyr Ile Leu Leu Phe Gly Val Gly Leu 
    610                 615                 620                 


Ser Tyr Cys Met Thr Phe Phe Phe Ile Ala Lys Pro Ser Pro Val Ile 
625                 630                 635                 640 


Cys Ala Leu Arg Arg Leu Gly Leu Gly Ser Ser Phe Ala Ile Cys Tyr 
                645                 650                 655     


Ser Ala Leu Leu Thr Lys Thr Asn Cys Ile Ala Arg Ile Phe Asp Gly 
            660                 665                 670         


Val Lys Asn Gly Ala Gln Arg Pro Lys Phe Ile Ser Pro Ser Ser Gln 
        675                 680                 685             


Val Phe Ile Cys Leu Gly Leu Ile Leu Val Gln Ile Val Met Val Ser 
    690                 695                 700                 


Val Trp Leu Ile Leu Glu Ala Pro Gly Thr Arg Arg Tyr Thr Leu Ala 
705                 710                 715                 720 


Glu Lys Arg Glu Thr Val Ile Leu Lys Cys Asn Val Lys Asp Ser Ser 
                725                 730                 735     


Met Leu Ile Ser Leu Thr Tyr Asp Val Ile Leu Val Ile Leu Cys Thr 
            740                 745                 750         


Val Tyr Ala Phe Lys Thr Arg Lys Cys Pro Glu Asn Phe Asn Glu Ala 
        755                 760                 765             


Lys Phe Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Ile Trp Leu Ala 
    770                 775                 780                 


Phe Leu Pro Ile Phe Tyr Val Thr Ser Ser Asp Tyr Arg Val Gln Thr 
785                 790                 795                 800 


Thr Thr Met Cys Ile Ser Val Ser Leu Ser Gly Phe Val Val Leu Gly 
                805                 810                 815     


Cys Leu Phe Ala Pro Lys Val His Ile Ile Leu Phe Gln Pro Gln Lys 
            820                 825                 830         


Asn Val Val Thr His Arg Leu His Leu Asn Arg Phe Ser Val Ser Gly 
        835                 840                 845             


Thr Gly Thr Thr Tyr Ser Gln Ser Ser Ala Ser Thr Tyr Val Pro Thr 
    850                 855                 860                 


Val Cys Asn Gly Arg Glu Val Leu Asp Ser Thr Thr Ser Ser Leu 
865                 870                 875                 


<210>  6243
<211>  537
<212>  PRT
<213>  Homo Sapiens

<400>  6243

Met Lys Met Leu Thr Arg Leu Gln Val Leu Thr Leu Ala Leu Phe Ser 
1               5                   10                  15      


Lys Gly Phe Leu Leu Ser Leu Gly Asp His Asn Phe Leu Arg Arg Glu 
            20                  25                  30          


Ile Lys Ile Glu Gly Asp Leu Val Leu Gly Gly Leu Phe Pro Ile Asn 
        35                  40                  45              


Glu Lys Gly Thr Gly Thr Glu Glu Cys Gly Arg Ile Asn Glu Asp Arg 
    50                  55                  60                  


Gly Ile Gln Arg Leu Glu Ala Met Leu Phe Ala Ile Asp Glu Ile Asn 
65                  70                  75                  80  


Lys Asp Asp Tyr Leu Leu Pro Gly Val Lys Leu Gly Val His Ile Leu 
                85                  90                  95      


Asp Thr Cys Ser Arg Asp Thr Tyr Ala Leu Glu Gln Ser Leu Glu Phe 
            100                 105                 110         


Val Arg Ala Ser Leu Thr Lys Val Asp Glu Ala Glu Tyr Met Cys Pro 
        115                 120                 125             


Asp Gly Ser Tyr Ala Ile Gln Glu Asn Ile Pro Leu Leu Ile Ala Gly 
    130                 135                 140                 


Val Ile Gly Gly Ser Tyr Ser Ser Val Ser Ile Gln Val Ala Asn Leu 
145                 150                 155                 160 


Leu Arg Leu Phe Gln Ile Pro Gln Ile Ser Tyr Ala Ser Thr Ser Ala 
                165                 170                 175     


Lys Leu Ser Asp Lys Ser Arg Tyr Asp Tyr Phe Ala Arg Thr Val Pro 
            180                 185                 190         


Pro Asp Phe Tyr Gln Ala Lys Ala Met Ala Glu Ile Leu Arg Phe Phe 
        195                 200                 205             


Asn Trp Thr Tyr Val Ser Thr Val Ala Ser Glu Gly Asp Tyr Gly Glu 
    210                 215                 220                 


Thr Gly Ile Glu Ala Phe Glu Gln Glu Ala Arg Leu Arg Asn Ile Cys 
225                 230                 235                 240 


Ile Ala Thr Ala Glu Lys Val Gly Arg Ser Asn Ile Arg Lys Ser Tyr 
                245                 250                 255     


Asp Ser Val Ile Arg Glu Leu Leu Gln Lys Pro Asn Ala Arg Val Val 
            260                 265                 270         


Val Leu Phe Met Arg Ser Asp Asp Ser Arg Glu Leu Ile Ala Ala Ala 
        275                 280                 285             


Ser Arg Ala Asn Ala Ser Phe Thr Trp Val Ala Ser Asp Gly Trp Gly 
    290                 295                 300                 


Ala Gln Glu Ser Ile Ile Lys Gly Ser Glu His Val Ala Tyr Gly Ala 
305                 310                 315                 320 


Ile Thr Leu Glu Leu Ala Ser Gln Pro Val Arg Gln Phe Asp Arg Tyr 
                325                 330                 335     


Phe Gln Ser Leu Asn Pro Tyr Asn Asn His Arg Asn Pro Trp Phe Arg 
            340                 345                 350         


Asp Phe Trp Glu Gln Lys Phe Gln Cys Ser Leu Gln Asn Lys Arg Asn 
        355                 360                 365             


His Arg Arg Val Cys Asp Lys His Leu Ala Ile Asp Ser Ser Asn Tyr 
    370                 375                 380                 


Glu Gln Glu Ser Lys Ile Met Phe Val Val Asn Ala Val Tyr Ala Met 
385                 390                 395                 400 


Ala His Ala Leu His Lys Met Gln Arg Thr Leu Cys Pro Asn Thr Thr 
                405                 410                 415     


Lys Leu Cys Asp Ala Met Lys Ile Leu Asp Gly Lys Lys Leu Tyr Lys 
            420                 425                 430         


Asp Tyr Leu Leu Lys Ile Asn Phe Thr Gly Ala Asp Asp Asn His Val 
        435                 440                 445             


His Leu Cys Gln Pro Glu Trp Leu Cys Gly Leu Gly Leu Phe Val Cys 
    450                 455                 460                 


Thr Gln Gly Ser His His Pro Val Ser Thr Pro Glu Glu Cys Cys His 
465                 470                 475                 480 


Thr Gln Thr Ala Pro Gln Gln Val Gln Cys Gln Trp Asn Trp Asp His 
                485                 490                 495     


Ile Leu Ser Val Leu Cys Lys His Val Cys Ala Asn Gly Val Gln Trp 
            500                 505                 510         


Ala Gly Ser Pro Arg Leu His His Leu Ile Ser Val Ile Val Asn Cys 
        515                 520                 525             


Ser Ser Val Leu Val Phe Leu Asp Cys 
    530                 535         


<210>  6244
<211>  171
<212>  PRT
<213>  Homo Sapiens

<400>  6244

Met Ser Gln Ser Pro Gly Ala Gly Ser Pro Pro Pro Leu Pro Pro Arg 
1               5                   10                  15      


Ser Ala Pro Val Pro Ala Arg Ser Cys Arg Cys Glu Val Ala Asn Leu 
            20                  25                  30          


Leu Arg Leu Phe Gln Ile Pro Gln Ile Ser Tyr Ala Ser Thr Ser Ala 
        35                  40                  45              


Lys Leu Ser Asp Lys Ser Arg Tyr Asp Tyr Phe Ala Arg Thr Val Pro 
    50                  55                  60                  


Pro Asp Phe Tyr Gln Ala Lys Ala Met Ala Glu Ile Leu Arg Phe Phe 
65                  70                  75                  80  


Asn Trp Thr Tyr Val Ser Thr Val Ala Ser Glu Gly Asp Tyr Gly Glu 
                85                  90                  95      


Thr Gly Ile Glu Ala Phe Glu Gln Glu Ala Arg Leu Arg Asn Ile Cys 
            100                 105                 110         


Ile Ala Thr Ala Glu Lys Val Gly Arg Ser Asn Ile Arg Lys Ser Tyr 
        115                 120                 125             


Asp Ser Val Ile Arg Glu Leu Leu Gln Lys Pro Asn Ala Arg Val Val 
    130                 135                 140                 


Val Leu Phe Met Arg Ser Asp Asp Ser Arg Glu Leu Ile Ala Ala Ala 
145                 150                 155                 160 


Ser Arg Ala Asn Ala Ser Phe Thr Trp Val Ala 
                165                 170     


<210>  6245
<211>  1212
<212>  PRT
<213>  Homo Sapiens

<400>  6245

Met Val Leu Leu Leu Ile Leu Ser Val Leu Leu Leu Lys Glu Asp Val 
1               5                   10                  15      


Arg Gly Ser Ala Gln Ser Ser Glu Arg Arg Val Val Ala His Met Pro 
            20                  25                  30          


Gly Asp Ile Ile Ile Gly Ala Leu Phe Ser Val His His Gln Pro Thr 
        35                  40                  45              


Val Asp Lys Val His Glu Arg Lys Cys Gly Ala Val Arg Glu Gln Tyr 
    50                  55                  60                  


Gly Ile Gln Arg Val Glu Ala Met Leu His Thr Leu Glu Arg Ile Asn 
65                  70                  75                  80  


Ser Asp Pro Thr Leu Leu Pro Asn Ile Thr Leu Gly Cys Glu Ile Arg 
                85                  90                  95      


Asp Ser Cys Trp His Ser Ala Val Ala Leu Glu Gln Ser Ile Glu Phe 
            100                 105                 110         


Ile Arg Asp Ser Leu Ile Ser Ser Glu Glu Glu Glu Gly Leu Val Arg 
        115                 120                 125             


Cys Val Asp Gly Ser Ser Ser Ser Phe Arg Ser Lys Lys Pro Ile Val 
    130                 135                 140                 


Gly Val Ile Gly Pro Gly Ser Ser Ser Val Ala Ile Gln Val Gln Asn 
145                 150                 155                 160 


Leu Leu Gln Leu Phe Asn Ile Pro Gln Ile Ala Tyr Ser Ala Thr Ser 
                165                 170                 175     


Met Asp Leu Ser Asp Lys Thr Leu Phe Lys Tyr Phe Met Arg Val Val 
            180                 185                 190         


Pro Ser Asp Ala Gln Gln Ala Arg Ala Met Val Asp Ile Val Lys Arg 
        195                 200                 205             


Tyr Asn Trp Thr Tyr Val Ser Ala Val His Thr Glu Gly Asn Tyr Gly 
    210                 215                 220                 


Glu Ser Gly Met Glu Ala Phe Lys Asp Met Ser Ala Lys Glu Gly Ile 
225                 230                 235                 240 


Cys Ile Ala His Ser Tyr Lys Ile Tyr Ser Asn Ala Gly Glu Gln Ser 
                245                 250                 255     


Phe Asp Lys Leu Leu Lys Lys Leu Thr Ser His Leu Pro Lys Ala Arg 
            260                 265                 270         


Val Val Ala Cys Phe Cys Glu Gly Met Thr Val Arg Gly Leu Leu Met 
        275                 280                 285             


Ala Met Arg Arg Leu Gly Leu Ala Gly Glu Phe Leu Leu Leu Gly Ser 
    290                 295                 300                 


Asp Gly Trp Ala Asp Arg Tyr Asp Val Thr Asp Gly Tyr Gln Arg Glu 
305                 310                 315                 320 


Ala Val Gly Gly Ile Thr Ile Lys Leu Gln Ser Pro Asp Val Lys Trp 
                325                 330                 335     


Phe Asp Asp Tyr Tyr Leu Lys Leu Arg Pro Glu Thr Asn His Arg Asn 
            340                 345                 350         


Pro Trp Phe Gln Glu Phe Trp Gln His Arg Phe Gln Cys Arg Leu Glu 
        355                 360                 365             


Gly Phe Pro Gln Glu Asn Ser Lys Tyr Asn Lys Thr Cys Asn Ser Ser 
    370                 375                 380                 


Leu Thr Leu Lys Thr His His Val Gln Asp Ser Lys Met Gly Phe Val 
385                 390                 395                 400 


Ile Asn Ala Ile Tyr Ser Met Ala Tyr Gly Leu His Asn Met Gln Met 
                405                 410                 415     


Ser Leu Cys Pro Gly Tyr Ala Gly Leu Cys Asp Ala Met Lys Pro Ile 
            420                 425                 430         


Asp Gly Arg Lys Leu Leu Glu Ser Leu Met Lys Thr Asn Phe Thr Gly 
        435                 440                 445             


Val Ser Gly Asp Thr Ile Leu Phe Asp Glu Asn Gly Asp Ser Pro Gly 
    450                 455                 460                 


Arg Tyr Glu Ile Met Asn Phe Lys Glu Met Gly Lys Asp Tyr Phe Asp 
465                 470                 475                 480 


Tyr Ile Asn Val Gly Ser Trp Asp Asn Gly Glu Leu Lys Met Asp Asp 
                485                 490                 495     


Asp Glu Val Trp Ser Lys Lys Ser Asn Ile Ile Arg Ser Val Cys Ser 
            500                 505                 510         


Glu Pro Cys Glu Lys Gly Gln Ile Lys Val Ile Arg Lys Gly Glu Val 
        515                 520                 525             


Ser Cys Cys Trp Thr Cys Thr Pro Cys Lys Glu Asn Glu Tyr Val Phe 
    530                 535                 540                 


Asp Glu Tyr Thr Cys Lys Ala Cys Gln Leu Gly Ser Trp Pro Thr Asp 
545                 550                 555                 560 


Asp Leu Thr Gly Cys Asp Leu Ile Pro Val Gln Tyr Leu Arg Trp Gly 
                565                 570                 575     


Asp Pro Glu Pro Ile Ala Ala Val Val Phe Ala Cys Leu Gly Leu Leu 
            580                 585                 590         


Ala Thr Leu Phe Val Thr Val Val Phe Ile Ile Tyr Arg Asp Thr Pro 
        595                 600                 605             


Val Val Lys Ser Ser Ser Arg Glu Leu Cys Tyr Ile Ile Leu Ala Gly 
    610                 615                 620                 


Ile Cys Leu Gly Tyr Leu Cys Thr Phe Cys Leu Ile Ala Lys Pro Lys 
625                 630                 635                 640 


Gln Ile Tyr Cys Tyr Leu Gln Arg Ile Gly Ile Gly Leu Ser Pro Ala 
                645                 650                 655     


Met Ser Tyr Ser Ala Leu Val Thr Lys Thr Asn Arg Ile Ala Arg Ile 
            660                 665                 670         


Leu Ala Gly Ser Lys Lys Lys Ile Cys Thr Lys Lys Pro Arg Phe Met 
        675                 680                 685             


Ser Ala Cys Ala Gln Leu Val Ile Ala Phe Ile Leu Ile Cys Ile Gln 
    690                 695                 700                 


Leu Gly Ile Ile Val Ala Leu Phe Ile Met Glu Pro Pro Asp Ile Met 
705                 710                 715                 720 


His Asp Tyr Pro Ser Ile Arg Glu Val Tyr Leu Ile Cys Asn Thr Thr 
                725                 730                 735     


Asn Leu Gly Val Val Thr Pro Leu Gly Tyr Asn Gly Leu Leu Ile Leu 
            740                 745                 750         


Ser Cys Thr Phe Tyr Ala Phe Lys Thr Arg Asn Val Pro Ala Asn Phe 
        755                 760                 765             


Asn Glu Ala Lys Tyr Ile Ala Phe Thr Met Tyr Thr Thr Cys Ile Ile 
    770                 775                 780                 


Trp Leu Ala Phe Val Pro Ile Tyr Phe Gly Ser Asn Tyr Lys Ile Ile 
785                 790                 795                 800 


Thr Met Cys Phe Ser Val Ser Leu Ser Ala Thr Val Ala Leu Gly Cys 
                805                 810                 815     


Met Phe Val Pro Lys Val Tyr Ile Ile Leu Ala Lys Pro Glu Arg Asn 
            820                 825                 830         


Val Arg Ser Ala Phe Thr Thr Ser Thr Val Val Arg Met His Val Gly 
        835                 840                 845             


Asp Gly Lys Ser Ser Ser Ala Ala Ser Arg Ser Ser Ser Leu Val Asn 
    850                 855                 860                 


Leu Trp Lys Arg Arg Gly Ser Ser Gly Glu Thr Leu Arg Tyr Lys Asp 
865                 870                 875                 880 


Arg Arg Leu Ala Gln His Lys Ser Glu Ile Glu Cys Phe Thr Pro Lys 
                885                 890                 895     


Gly Ser Met Gly Asn Gly Gly Arg Ala Thr Met Ser Ser Ser Asn Gly 
            900                 905                 910         


Lys Ser Val Thr Trp Ala Gln Asn Glu Lys Ser Ser Arg Gly Gln His 
        915                 920                 925             


Leu Trp Gln Arg Leu Ser Ile His Ile Asn Lys Lys Glu Asn Pro Asn 
    930                 935                 940                 


Gln Thr Ala Val Ile Lys Pro Phe Pro Lys Ser Thr Glu Ser Arg Gly 
945                 950                 955                 960 


Leu Gly Ala Gly Ala Gly Ala Gly Gly Ser Ala Gly Gly Val Gly Ala 
                965                 970                 975     


Thr Gly Gly Ala Gly Cys Ala Gly Ala Gly Pro Gly Gly Pro Glu Ser 
            980                 985                 990         


Pro Asp Ala Gly Pro Lys Ala Leu  Tyr Asp Val Ala Glu  Ala Glu Glu 
        995                 1000                 1005             


His Phe  Pro Ala Pro Ala Arg  Pro Arg Ser Pro Ser  Pro Ile Ser 
    1010                 1015                 1020             


Thr Leu  Ser His Arg Ala Gly  Ser Ala Ser Arg Thr  Asp Asp Asp 
    1025                 1030                 1035             


Val Pro  Ser Leu His Ser Glu  Pro Val Ala Arg Ser  Ser Ser Ser 
    1040                 1045                 1050             


Gln Gly  Ser Leu Met Glu Gln  Ile Ser Ser Val Val  Thr Arg Phe 
    1055                 1060                 1065             


Thr Ala  Asn Ile Ser Glu Leu  Asn Ser Met Met Leu  Ser Thr Ala 
    1070                 1075                 1080             


Ala Pro  Ser Pro Gly Val Gly  Ala Pro Leu Cys Ser  Ser Tyr Leu 
    1085                 1090                 1095             


Ile Pro  Lys Glu Ile Gln Leu  Pro Thr Thr Met Thr  Thr Phe Ala 
    1100                 1105                 1110             


Glu Ile  Gln Pro Leu Pro Ala  Ile Glu Val Thr Gly  Gly Ala Gln 
    1115                 1120                 1125             


Pro Ala  Ala Gly Ala Gln Ala  Ala Gly Asp Ala Ala  Arg Glu Ser 
    1130                 1135                 1140             


Pro Ala  Ala Gly Pro Glu Ala  Ala Ala Ala Lys Pro  Asp Leu Glu 
    1145                 1150                 1155             


Glu Leu  Val Ala Leu Thr Pro  Pro Ser Pro Phe Arg  Asp Ser Val 
    1160                 1165                 1170             


Asp Ser  Gly Ser Thr Thr Pro  Asn Ser Pro Val Ser  Glu Ser Ala 
    1175                 1180                 1185             


Leu Cys  Ile Pro Ser Ser Pro  Lys Tyr Asp Thr Leu  Ile Ile Arg 
    1190                 1195                 1200             


Asp Tyr  Thr Gln Ser Ser Ser  Ser Leu 
    1205                 1210         


<210>  6246
<211>  1180
<212>  PRT
<213>  Homo Sapiens

<400>  6246

Met Val Leu Leu Leu Ile Leu Ser Val Leu Leu Leu Lys Glu Asp Val 
1               5                   10                  15      


Arg Gly Ser Ala Gln Ser Ser Glu Arg Arg Val Val Ala His Met Pro 
            20                  25                  30          


Gly Asp Ile Ile Ile Gly Ala Leu Phe Ser Val His His Gln Pro Thr 
        35                  40                  45              


Val Asp Lys Val His Glu Arg Lys Cys Gly Ala Val Arg Glu Gln Tyr 
    50                  55                  60                  


Gly Ile Gln Arg Val Glu Ala Met Leu His Thr Leu Glu Arg Ile Asn 
65                  70                  75                  80  


Ser Asp Pro Thr Leu Leu Pro Asn Ile Thr Leu Gly Cys Glu Ile Arg 
                85                  90                  95      


Asp Ser Cys Trp His Ser Ala Val Ala Leu Glu Gln Ser Ile Glu Phe 
            100                 105                 110         


Ile Arg Asp Ser Leu Ile Ser Ser Glu Glu Glu Glu Gly Leu Val Arg 
        115                 120                 125             


Cys Val Asp Gly Ser Ser Ser Ser Phe Arg Ser Lys Lys Pro Ile Val 
    130                 135                 140                 


Gly Val Ile Gly Pro Gly Ser Ser Ser Val Ala Ile Gln Val Gln Asn 
145                 150                 155                 160 


Leu Leu Gln Leu Phe Asn Ile Pro Gln Ile Ala Tyr Ser Ala Thr Ser 
                165                 170                 175     


Met Asp Leu Ser Asp Lys Thr Leu Phe Lys Tyr Phe Met Arg Val Val 
            180                 185                 190         


Pro Ser Asp Ala Gln Gln Ala Arg Ala Met Val Asp Ile Val Lys Arg 
        195                 200                 205             


Tyr Asn Trp Thr Tyr Val Ser Ala Val His Thr Glu Gly Asn Tyr Gly 
    210                 215                 220                 


Glu Ser Gly Met Glu Ala Phe Lys Asp Met Ser Ala Lys Glu Gly Ile 
225                 230                 235                 240 


Cys Ile Ala His Ser Tyr Lys Ile Tyr Ser Asn Ala Gly Glu Gln Ser 
                245                 250                 255     


Phe Asp Lys Leu Leu Lys Lys Leu Thr Ser His Leu Pro Lys Ala Arg 
            260                 265                 270         


Val Val Ala Cys Phe Cys Glu Gly Met Thr Val Arg Gly Leu Leu Met 
        275                 280                 285             


Ala Met Arg Arg Leu Gly Leu Ala Gly Glu Phe Leu Leu Leu Gly Ser 
    290                 295                 300                 


Asp Gly Trp Ala Asp Arg Tyr Asp Val Thr Asp Gly Tyr Gln Arg Glu 
305                 310                 315                 320 


Ala Val Gly Gly Ile Thr Ile Lys Leu Gln Ser Pro Asp Val Lys Trp 
                325                 330                 335     


Phe Asp Asp Tyr Tyr Leu Lys Leu Arg Pro Glu Thr Asn His Arg Asn 
            340                 345                 350         


Pro Trp Phe Gln Glu Phe Trp Gln His Arg Phe Gln Cys Arg Leu Glu 
        355                 360                 365             


Gly Phe Pro Gln Glu Asn Ser Lys Tyr Asn Lys Thr Cys Asn Ser Ser 
    370                 375                 380                 


Leu Thr Leu Lys Thr His His Val Gln Asp Ser Lys Met Gly Phe Val 
385                 390                 395                 400 


Ile Asn Ala Ile Tyr Ser Met Ala Tyr Gly Leu His Asn Met Gln Met 
                405                 410                 415     


Ser Leu Cys Pro Gly Tyr Ala Gly Leu Cys Asp Ala Met Lys Pro Ile 
            420                 425                 430         


Asp Gly Arg Lys Leu Leu Glu Ser Leu Met Lys Thr Asn Phe Thr Gly 
        435                 440                 445             


Val Ser Gly Asp Thr Ile Leu Phe Asp Glu Asn Gly Asp Ser Pro Gly 
    450                 455                 460                 


Arg Tyr Glu Ile Met Asn Phe Lys Glu Met Gly Lys Asp Tyr Phe Asp 
465                 470                 475                 480 


Tyr Ile Asn Val Gly Ser Trp Asp Asn Gly Glu Leu Lys Met Asp Asp 
                485                 490                 495     


Asp Glu Val Trp Ser Lys Lys Ser Asn Ile Ile Arg Ser Val Cys Ser 
            500                 505                 510         


Glu Pro Cys Glu Lys Gly Gln Ile Lys Val Ile Arg Lys Gly Glu Val 
        515                 520                 525             


Ser Cys Cys Trp Thr Cys Thr Pro Cys Lys Glu Asn Glu Tyr Val Phe 
    530                 535                 540                 


Asp Glu Tyr Thr Cys Lys Ala Cys Gln Leu Gly Ser Trp Pro Thr Asp 
545                 550                 555                 560 


Asp Leu Thr Gly Cys Asp Leu Ile Pro Val Gln Tyr Leu Arg Trp Gly 
                565                 570                 575     


Asp Pro Glu Pro Ile Ala Ala Val Val Phe Ala Cys Leu Gly Leu Leu 
            580                 585                 590         


Ala Thr Leu Phe Val Thr Val Val Phe Ile Ile Tyr Arg Asp Thr Pro 
        595                 600                 605             


Val Val Lys Ser Ser Ser Arg Glu Leu Cys Tyr Ile Ile Leu Ala Gly 
    610                 615                 620                 


Ile Cys Leu Gly Tyr Leu Cys Thr Phe Cys Leu Ile Ala Lys Pro Lys 
625                 630                 635                 640 


Gln Ile Tyr Cys Tyr Leu Gln Arg Ile Gly Ile Gly Leu Ser Pro Ala 
                645                 650                 655     


Met Ser Tyr Ser Ala Leu Val Thr Lys Thr Asn Arg Ile Ala Arg Ile 
            660                 665                 670         


Leu Ala Gly Ser Lys Lys Lys Ile Cys Thr Lys Lys Pro Arg Phe Met 
        675                 680                 685             


Ser Ala Cys Ala Gln Leu Val Ile Ala Phe Ile Leu Ile Cys Ile Gln 
    690                 695                 700                 


Leu Gly Ile Ile Val Ala Leu Phe Ile Met Glu Pro Pro Asp Ile Met 
705                 710                 715                 720 


His Asp Tyr Pro Ser Ile Arg Glu Val Tyr Leu Ile Cys Asn Thr Thr 
                725                 730                 735     


Asn Leu Gly Val Val Thr Pro Leu Gly Tyr Asn Gly Leu Leu Ile Leu 
            740                 745                 750         


Ser Cys Thr Phe Tyr Ala Phe Lys Thr Arg Asn Val Pro Ala Asn Phe 
        755                 760                 765             


Asn Glu Ala Lys Tyr Ile Ala Phe Thr Met Tyr Thr Thr Cys Ile Ile 
    770                 775                 780                 


Trp Leu Ala Phe Val Pro Ile Tyr Phe Gly Ser Asn Tyr Lys Ile Ile 
785                 790                 795                 800 


Thr Met Cys Phe Ser Val Ser Leu Ser Ala Thr Val Ala Leu Gly Cys 
                805                 810                 815     


Met Phe Val Pro Lys Val Tyr Ile Ile Leu Ala Lys Pro Glu Arg Asn 
            820                 825                 830         


Val Arg Ser Ala Phe Thr Thr Ser Thr Val Val Arg Met His Val Gly 
        835                 840                 845             


Asp Gly Lys Ser Ser Ser Ala Ala Ser Arg Ser Ser Ser Leu Val Asn 
    850                 855                 860                 


Leu Trp Lys Arg Arg Gly Ser Ser Gly Glu Thr Leu Ser Ser Asn Gly 
865                 870                 875                 880 


Lys Ser Val Thr Trp Ala Gln Asn Glu Lys Ser Ser Arg Gly Gln His 
                885                 890                 895     


Leu Trp Gln Arg Leu Ser Ile His Ile Asn Lys Lys Glu Asn Pro Asn 
            900                 905                 910         


Gln Thr Ala Val Ile Lys Pro Phe Pro Lys Ser Thr Glu Ser Arg Gly 
        915                 920                 925             


Leu Gly Ala Gly Ala Gly Ala Gly Gly Ser Ala Gly Gly Val Gly Ala 
    930                 935                 940                 


Thr Gly Gly Ala Gly Cys Ala Gly Ala Gly Pro Gly Gly Pro Glu Ser 
945                 950                 955                 960 


Pro Asp Ala Gly Pro Lys Ala Leu Tyr Asp Val Ala Glu Ala Glu Glu 
                965                 970                 975     


His Phe Pro Ala Pro Ala Arg Pro Arg Ser Pro Ser Pro Ile Ser Thr 
            980                 985                 990         


Leu Ser His Arg Ala Gly Ser Ala  Ser Arg Thr Asp Asp  Asp Val Pro 
        995                 1000                 1005             


Ser Leu  His Ser Glu Pro Val  Ala Arg Ser Ser Ser  Ser Gln Gly 
    1010                 1015                 1020             


Ser Leu  Met Glu Gln Ile Ser  Ser Val Val Thr Arg  Phe Thr Ala 
    1025                 1030                 1035             


Asn Ile  Ser Glu Leu Asn Ser  Met Met Leu Ser Thr  Ala Ala Pro 
    1040                 1045                 1050             


Ser Pro  Gly Val Gly Ala Pro  Leu Cys Ser Ser Tyr  Leu Ile Pro 
    1055                 1060                 1065             


Lys Glu  Ile Gln Leu Pro Thr  Thr Met Thr Thr Phe  Ala Glu Ile 
    1070                 1075                 1080             


Gln Pro  Leu Pro Ala Ile Glu  Val Thr Gly Gly Ala  Gln Pro Ala 
    1085                 1090                 1095             


Ala Gly  Ala Gln Ala Ala Gly  Asp Ala Ala Arg Glu  Ser Pro Ala 
    1100                 1105                 1110             


Ala Gly  Pro Glu Ala Ala Ala  Ala Lys Pro Asp Leu  Glu Glu Leu 
    1115                 1120                 1125             


Val Ala  Leu Thr Pro Pro Ser  Pro Phe Arg Asp Ser  Val Asp Ser 
    1130                 1135                 1140             


Gly Ser  Thr Thr Pro Asn Ser  Pro Val Ser Glu Ser  Ala Leu Cys 
    1145                 1150                 1155             


Ile Pro  Ser Ser Pro Lys Tyr  Asp Thr Leu Ile Ile  Arg Asp Tyr 
    1160                 1165                 1170             


Thr Gln  Ser Ser Ser Ser Leu  
    1175                 1180 


<210>  6247
<211>  1180
<212>  PRT
<213>  Homo Sapiens

<400>  6247

Met Val Leu Leu Leu Ile Leu Ser Val Leu Leu Leu Lys Glu Asp Val 
1               5                   10                  15      


Arg Gly Ser Ala Gln Ser Ser Glu Arg Arg Val Val Ala His Met Pro 
            20                  25                  30          


Gly Asp Ile Ile Ile Gly Ala Leu Phe Ser Val His His Gln Pro Thr 
        35                  40                  45              


Val Asp Lys Val His Glu Arg Lys Cys Gly Ala Val Arg Glu Gln Tyr 
    50                  55                  60                  


Gly Ile Gln Arg Val Glu Ala Met Leu His Thr Leu Glu Arg Ile Asn 
65                  70                  75                  80  


Ser Asp Pro Thr Leu Leu Pro Asn Ile Thr Leu Gly Cys Glu Ile Arg 
                85                  90                  95      


Asp Ser Cys Trp His Ser Ala Val Ala Leu Glu Gln Ser Ile Glu Phe 
            100                 105                 110         


Ile Arg Asp Ser Leu Ile Ser Ser Glu Glu Glu Glu Gly Leu Val Arg 
        115                 120                 125             


Cys Val Asp Gly Ser Ser Ser Ser Phe Arg Ser Lys Lys Pro Ile Val 
    130                 135                 140                 


Gly Val Ile Gly Pro Gly Ser Ser Ser Val Ala Ile Gln Val Gln Asn 
145                 150                 155                 160 


Leu Leu Gln Leu Phe Asn Ile Pro Gln Ile Ala Tyr Ser Ala Thr Ser 
                165                 170                 175     


Met Asp Leu Ser Asp Lys Thr Leu Phe Lys Tyr Phe Met Arg Val Val 
            180                 185                 190         


Pro Ser Asp Ala Gln Gln Ala Arg Ala Met Val Asp Ile Val Lys Arg 
        195                 200                 205             


Tyr Asn Trp Thr Tyr Val Ser Ala Val His Thr Glu Gly Asn Tyr Gly 
    210                 215                 220                 


Glu Ser Gly Met Glu Ala Phe Lys Asp Met Ser Ala Lys Glu Gly Ile 
225                 230                 235                 240 


Cys Ile Ala His Ser Tyr Lys Ile Tyr Ser Asn Ala Gly Glu Gln Ser 
                245                 250                 255     


Phe Asp Lys Leu Leu Lys Lys Leu Thr Ser His Leu Pro Lys Ala Arg 
            260                 265                 270         


Val Val Ala Cys Phe Cys Glu Gly Met Thr Val Arg Gly Leu Leu Met 
        275                 280                 285             


Ala Met Arg Arg Leu Gly Leu Ala Gly Glu Phe Leu Leu Leu Gly Ser 
    290                 295                 300                 


Asp Gly Trp Ala Asp Arg Tyr Asp Val Thr Asp Gly Tyr Gln Arg Glu 
305                 310                 315                 320 


Ala Val Gly Gly Ile Thr Ile Lys Leu Gln Ser Pro Asp Val Lys Trp 
                325                 330                 335     


Phe Asp Asp Tyr Tyr Leu Lys Leu Arg Pro Glu Thr Asn His Arg Asn 
            340                 345                 350         


Pro Trp Phe Gln Glu Phe Trp Gln His Arg Phe Gln Cys Arg Leu Glu 
        355                 360                 365             


Gly Phe Pro Gln Glu Asn Ser Lys Tyr Asn Lys Thr Cys Asn Ser Ser 
    370                 375                 380                 


Leu Thr Leu Lys Thr His His Val Gln Asp Ser Lys Met Gly Phe Val 
385                 390                 395                 400 


Ile Asn Ala Ile Tyr Ser Met Ala Tyr Gly Leu His Asn Met Gln Met 
                405                 410                 415     


Ser Leu Cys Pro Gly Tyr Ala Gly Leu Cys Asp Ala Met Lys Pro Ile 
            420                 425                 430         


Asp Gly Arg Lys Leu Leu Glu Ser Leu Met Lys Thr Asn Phe Thr Gly 
        435                 440                 445             


Val Ser Gly Asp Thr Ile Leu Phe Asp Glu Asn Gly Asp Ser Pro Gly 
    450                 455                 460                 


Arg Tyr Glu Ile Met Asn Phe Lys Glu Met Gly Lys Asp Tyr Phe Asp 
465                 470                 475                 480 


Tyr Ile Asn Val Gly Ser Trp Asp Asn Gly Glu Leu Lys Met Asp Asp 
                485                 490                 495     


Asp Glu Val Trp Ser Lys Lys Ser Asn Ile Ile Arg Ser Val Cys Ser 
            500                 505                 510         


Glu Pro Cys Glu Lys Gly Gln Ile Lys Val Ile Arg Lys Gly Glu Val 
        515                 520                 525             


Ser Cys Cys Trp Thr Cys Thr Pro Cys Lys Glu Asn Glu Tyr Val Phe 
    530                 535                 540                 


Asp Glu Tyr Thr Cys Lys Ala Cys Gln Leu Gly Ser Trp Pro Thr Asp 
545                 550                 555                 560 


Asp Leu Thr Gly Cys Asp Leu Ile Pro Val Gln Tyr Leu Arg Trp Gly 
                565                 570                 575     


Asp Pro Glu Pro Ile Ala Ala Val Val Phe Ala Cys Leu Gly Leu Leu 
            580                 585                 590         


Ala Thr Leu Phe Val Thr Val Val Phe Ile Ile Tyr Arg Asp Thr Pro 
        595                 600                 605             


Val Val Lys Ser Ser Ser Arg Glu Leu Cys Tyr Ile Ile Leu Ala Gly 
    610                 615                 620                 


Ile Cys Leu Gly Tyr Leu Cys Thr Phe Cys Leu Ile Ala Lys Pro Lys 
625                 630                 635                 640 


Gln Ile Tyr Cys Tyr Leu Gln Arg Ile Gly Ile Gly Leu Ser Pro Ala 
                645                 650                 655     


Met Ser Tyr Ser Ala Leu Val Thr Lys Thr Asn Arg Ile Ala Arg Ile 
            660                 665                 670         


Leu Ala Gly Ser Lys Lys Lys Ile Cys Thr Lys Lys Pro Arg Phe Met 
        675                 680                 685             


Ser Ala Cys Ala Gln Leu Val Ile Ala Phe Ile Leu Ile Cys Ile Gln 
    690                 695                 700                 


Leu Gly Ile Ile Val Ala Leu Phe Ile Met Glu Pro Pro Asp Ile Met 
705                 710                 715                 720 


His Asp Tyr Pro Ser Ile Arg Glu Val Tyr Leu Ile Cys Asn Thr Thr 
                725                 730                 735     


Asn Leu Gly Val Val Thr Pro Leu Gly Tyr Asn Gly Leu Leu Ile Leu 
            740                 745                 750         


Ser Cys Thr Phe Tyr Ala Phe Lys Thr Arg Asn Val Pro Ala Asn Phe 
        755                 760                 765             


Asn Glu Ala Lys Tyr Ile Ala Phe Thr Met Tyr Thr Thr Cys Ile Ile 
    770                 775                 780                 


Trp Leu Ala Phe Val Pro Ile Tyr Phe Gly Ser Asn Tyr Lys Ile Ile 
785                 790                 795                 800 


Thr Met Cys Phe Ser Val Ser Leu Ser Ala Thr Val Ala Leu Gly Cys 
                805                 810                 815     


Met Phe Val Pro Lys Val Tyr Ile Ile Leu Ala Lys Pro Glu Arg Asn 
            820                 825                 830         


Val Arg Ser Ala Phe Thr Thr Ser Thr Val Val Arg Met His Val Gly 
        835                 840                 845             


Asp Gly Lys Ser Ser Ser Ala Ala Ser Arg Ser Ser Ser Leu Val Asn 
    850                 855                 860                 


Leu Trp Lys Arg Arg Gly Ser Ser Gly Glu Thr Leu Ser Ser Asn Gly 
865                 870                 875                 880 


Lys Ser Val Thr Trp Ala Gln Asn Glu Lys Ser Ser Arg Gly Gln His 
                885                 890                 895     


Leu Trp Gln Arg Leu Ser Ile His Ile Asn Lys Lys Glu Asn Pro Asn 
            900                 905                 910         


Gln Thr Ala Val Ile Lys Pro Phe Pro Lys Ser Thr Glu Ser Arg Gly 
        915                 920                 925             


Leu Gly Ala Gly Ala Gly Ala Gly Gly Ser Ala Gly Gly Val Gly Ala 
    930                 935                 940                 


Thr Gly Gly Ala Gly Cys Ala Gly Ala Gly Pro Gly Gly Pro Glu Ser 
945                 950                 955                 960 


Pro Asp Ala Gly Pro Lys Ala Leu Tyr Asp Val Ala Glu Ala Glu Glu 
                965                 970                 975     


His Phe Pro Ala Pro Ala Arg Pro Arg Ser Pro Ser Pro Ile Ser Thr 
            980                 985                 990         


Leu Ser His Arg Ala Gly Ser Ala  Ser Arg Thr Asp Asp  Asp Val Pro 
        995                 1000                 1005             


Ser Leu  His Ser Glu Pro Val  Ala Arg Ser Ser Ser  Ser Gln Gly 
    1010                 1015                 1020             


Ser Leu  Met Glu Gln Ile Ser  Ser Val Val Thr Arg  Phe Thr Ala 
    1025                 1030                 1035             


Asn Ile  Ser Glu Leu Asn Ser  Met Met Leu Ser Thr  Ala Ala Pro 
    1040                 1045                 1050             


Ser Pro  Gly Val Gly Ala Pro  Leu Cys Ser Ser Tyr  Leu Ile Pro 
    1055                 1060                 1065             


Lys Glu  Ile Gln Leu Pro Thr  Thr Met Thr Thr Phe  Ala Glu Ile 
    1070                 1075                 1080             


Gln Pro  Leu Pro Ala Ile Glu  Val Thr Gly Gly Ala  Gln Pro Ala 
    1085                 1090                 1095             


Ala Gly  Ala Gln Ala Ala Gly  Asp Ala Ala Arg Glu  Ser Pro Ala 
    1100                 1105                 1110             


Ala Gly  Pro Glu Ala Ala Ala  Ala Lys Pro Asp Leu  Glu Glu Leu 
    1115                 1120                 1125             


Val Ala  Leu Thr Pro Pro Ser  Pro Phe Arg Asp Ser  Val Asp Ser 
    1130                 1135                 1140             


Gly Ser  Thr Thr Pro Asn Ser  Pro Val Ser Glu Ser  Ala Leu Cys 
    1145                 1150                 1155             


Ile Pro  Ser Ser Pro Lys Tyr  Asp Thr Leu Ile Ile  Arg Asp Tyr 
    1160                 1165                 1170             


Thr Gln  Ser Ser Ser Ser Leu  
    1175                 1180 


<210>  6248
<211>  298
<212>  PRT
<213>  Homo Sapiens

<400>  6248

Met Val Leu Leu Leu Ile Leu Ser Val Leu Leu Leu Lys Glu Asp Val 
1               5                   10                  15      


Arg Gly Ser Ala Gln Ser Ser Glu Arg Arg Val Val Ala His Met Pro 
            20                  25                  30          


Gly Asp Ile Ile Ile Gly Ala Leu Phe Ser Val His His Gln Pro Thr 
        35                  40                  45              


Val Asp Lys Val His Glu Arg Lys Cys Gly Ala Val Arg Glu Gln Tyr 
    50                  55                  60                  


Gly Ile Gln Arg Val Glu Ala Met Leu His Thr Leu Glu Arg Ile Asn 
65                  70                  75                  80  


Ser Asp Pro Thr Leu Leu Pro Asn Ile Thr Leu Gly Cys Glu Ile Arg 
                85                  90                  95      


Asp Ser Cys Trp His Ser Ala Val Ala Leu Glu Gln Ser Ile Glu Phe 
            100                 105                 110         


Ile Arg Asp Ser Leu Ile Ser Ser Glu Glu Glu Glu Gly Leu Val Arg 
        115                 120                 125             


Cys Val Asp Gly Ser Ser Ser Ser Phe Arg Ser Lys Lys Pro Ile Val 
    130                 135                 140                 


Gly Val Ile Gly Pro Gly Ser Ser Ser Val Ala Ile Gln Val Gln Asn 
145                 150                 155                 160 


Leu Leu Gln Leu Phe Asn Ile Pro Gln Ile Ala Tyr Ser Ala Thr Ser 
                165                 170                 175     


Met Asp Leu Ser Asp Lys Thr Leu Phe Lys Tyr Phe Met Arg Val Val 
            180                 185                 190         


Pro Ser Asp Ala Gln Gln Ala Arg Ala Met Val Asp Ile Val Lys Arg 
        195                 200                 205             


Tyr Asn Trp Thr Tyr Val Ser Ala Val His Thr Glu Gly Arg Gly Thr 
    210                 215                 220                 


Lys Lys Glu Glu Met Arg Lys Arg Asp Gln Thr Leu Met Leu Ser Phe 
225                 230                 235                 240 


Met Arg Cys Val Phe Leu Arg Phe Glu Glu Ile Arg Trp Asn Asp Ser 
                245                 250                 255     


Leu Val Tyr Asp Ala Leu Glu Asn Glu Asn Ile Gln Val Leu Ser Leu 
            260                 265                 270         


Cys Phe Pro Ser Ser Ala Val Ile Gln Ile Asn Thr Phe Leu Ser Pro 
        275                 280                 285             


Ile Ala Leu Ile Asn Arg Leu Asn Val Thr 
    290                 295             


<210>  6249
<211>  87
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6249

Xaa Gln Ile Ala Tyr Ser Ala Thr Ser Met Asp Leu Ser Asp Lys Thr 
1               5                   10                  15      


Leu Phe Lys Tyr Phe Met Arg Val Val Pro Ser Asp Ala Gln Gln Ala 
            20                  25                  30          


Arg Ala Met Val Asp Ile Val Lys Arg Tyr Asn Trp Thr Tyr Val Ser 
        35                  40                  45              


Ala Val His Thr Glu Gly Arg Gly Thr Lys Lys Glu Glu Met Arg Lys 
    50                  55                  60                  


Arg Asp Gln Thr Leu Met Leu Ser Phe Met Arg Phe Lys Leu Phe Ser 
65                  70                  75                  80  


Cys Leu Ser Leu Gln Arg Ser 
                85          


<210>  6250
<211>  37
<212>  PRT
<213>  Homo Sapiens

<400>  6250

Met Trp Thr Leu Val Ser Trp Val Ala Leu Thr Ala Gly Leu Val Ala 
1               5                   10                  15      


Gly Thr Arg Cys Pro Asp Gly Gln Phe Cys Pro Val Ala Cys Cys Leu 
            20                  25                  30          


Asp Pro Gly Gly Ala 
        35          


<210>  6251
<211>  62
<212>  PRT
<213>  Homo Sapiens

<400>  6251

Met Trp Thr Leu Val Ser Trp Val Ala Leu Thr Ala Gly Leu Val Ala 
1               5                   10                  15      


Gly Thr Arg Cys Pro Asp Gly Gln Phe Cys Pro Val Ala Cys Cys Leu 
            20                  25                  30          


Asp Pro Gly Gly Ala Ser Tyr Ser Cys Cys Arg Pro Leu Leu Asp Lys 
        35                  40                  45              


Trp Pro Thr Thr Leu Ser Arg His Leu Gly Gly Pro Cys Gln 
    50                  55                  60          


<210>  6252
<211>  172
<212>  PRT
<213>  Homo Sapiens

<400>  6252

Met Trp Thr Leu Val Ser Trp Val Ala Leu Thr Ala Gly Leu Val Ala 
1               5                   10                  15      


Gly Thr Arg Cys Pro Asp Gly Gln Phe Cys Pro Val Ala Cys Cys Leu 
            20                  25                  30          


Asp Pro Gly Gly Ala Ser Tyr Ser Cys Cys Arg Pro Leu Leu Asp Lys 
        35                  40                  45              


Trp Pro Thr Thr Leu Ser Arg His Leu Gly Gly Pro Cys Gln Val Asp 
    50                  55                  60                  


Ala His Cys Ser Ala Gly His Ser Cys Ile Phe Thr Val Ser Gly Thr 
65                  70                  75                  80  


Ser Ser Cys Cys Pro Phe Pro Glu Ala Ser Cys Cys Glu Asp Arg Val 
                85                  90                  95      


His Cys Cys Pro His Gly Ala Phe Cys Asp Leu Val His Thr Arg Cys 
            100                 105                 110         


Ile Thr Pro Thr Gly Thr His Pro Leu Ala Lys Lys Leu Pro Ala Gln 
        115                 120                 125             


Arg Thr Asn Arg Ala Val Ala Leu Ser Ser Ser Val Met Cys Pro Asp 
    130                 135                 140                 


Ala Arg Ser Arg Cys Pro Asp Gly Ser Thr Cys Cys Glu Leu Pro Ser 
145                 150                 155                 160 


Gly Lys Tyr Gly Cys Cys Pro Met Pro Asn Ala Thr 
                165                 170         


<210>  6253
<211>  111
<212>  PRT
<213>  Homo Sapiens

<400>  6253

Met Trp Thr Leu Val Ser Trp Val Ala Leu Thr Ala Gly Leu Val Ala 
1               5                   10                  15      


Gly Thr Arg Cys Pro Asp Gly Gln Phe Cys Pro Val Ala Cys Cys Leu 
            20                  25                  30          


Asp Pro Gly Gly Ala Ser Tyr Ser Cys Cys Arg Pro Leu Leu Asp Lys 
        35                  40                  45              


Trp Pro Thr Thr Leu Ser Arg His Leu Gly Gly Pro Cys Gln Val Asp 
    50                  55                  60                  


Ala His Cys Ser Ala Gly His Ser Cys Ile Phe Thr Val Ser Gly Thr 
65                  70                  75                  80  


Ser Ser Cys Cys Pro Phe Pro Glu Ala Val Ala Cys Gly Asp Gly His 
                85                  90                  95      


His Cys Cys Pro Arg Gly Phe His Cys Ser Ala Asp Gly Arg Ser 
            100                 105                 110     


<210>  6254
<211>  135
<212>  PRT
<213>  Homo Sapiens

<400>  6254

Met Trp Thr Leu Val Ser Trp Val Ala Leu Thr Ala Gly Leu Val Ala 
1               5                   10                  15      


Gly Thr Arg Cys Pro Asp Gly Gln Phe Cys Pro Val Ala Cys Cys Leu 
            20                  25                  30          


Asp Pro Gly Gly Ala Ser Tyr Ser Cys Cys Arg Pro Leu Leu Asp Lys 
        35                  40                  45              


Trp Pro Thr Thr Leu Ser Arg His Leu Gly Gly Pro Cys Gln Val Asp 
    50                  55                  60                  


Ala His Cys Ser Ala Gly His Ser Cys Ile Phe Thr Val Ser Gly Thr 
65                  70                  75                  80  


Ser Ser Cys Cys Pro Phe Pro Glu Ala Val Ala Cys Gly Asp Gly His 
                85                  90                  95      


His Cys Cys Pro Arg Gly Phe His Cys Ser Ala Asp Gly Arg Ser Cys 
            100                 105                 110         


Phe Gln Arg Ser Gly Asn Asn Ser Val Gly Ala Ile Gln Cys Pro Asp 
        115                 120                 125             


Ser Gln Phe Glu Cys Pro Asp 
    130                 135 


<210>  6255
<211>  136
<212>  PRT
<213>  Homo Sapiens

<400>  6255

Met Trp Thr Leu Val Ser Trp Val Ala Leu Thr Ala Gly Leu Val Ala 
1               5                   10                  15      


Gly Thr Arg Cys Pro Asp Gly Gln Phe Cys Pro Val Ala Cys Cys Leu 
            20                  25                  30          


Asp Pro Gly Gly Ala Ser Tyr Ser Cys Cys Arg Pro Leu Leu Asp Lys 
        35                  40                  45              


Trp Pro Thr Thr Leu Ser Arg His Leu Gly Gly Pro Cys Gln Val Asp 
    50                  55                  60                  


Ala His Cys Ser Ala Gly His Ser Cys Ile Phe Thr Val Ser Gly Thr 
65                  70                  75                  80  


Ser Ser Cys Cys Pro Phe Pro Glu Ala Val Ala Cys Gly Asp Gly His 
                85                  90                  95      


His Cys Cys Pro Arg Gly Phe His Cys Ser Ala Asp Gly Arg Ser Cys 
            100                 105                 110         


Phe Gln Arg Ser Gly Asn Asn Ser Val Gly Ala Ile Gln Cys Pro Asp 
        115                 120                 125             


Ser Gln Phe Glu Cys Pro Asp Phe 
    130                 135     


<210>  6256
<211>  142
<212>  PRT
<213>  Homo Sapiens

<400>  6256

Met Trp Thr Leu Val Ser Trp Val Ala Leu Thr Ala Gly Leu Val Ala 
1               5                   10                  15      


Gly Thr Arg Cys Pro Asp Gly Gln Phe Cys Pro Val Ala Cys Cys Leu 
            20                  25                  30          


Asp Pro Gly Gly Ala Ser Tyr Ser Cys Cys Arg Pro Leu Leu Asp Lys 
        35                  40                  45              


Trp Pro Thr Thr Leu Ser Arg His Leu Gly Gly Pro Cys Gln Val Asp 
    50                  55                  60                  


Ala His Cys Ser Ala Gly His Ser Cys Ile Phe Thr Val Ser Gly Thr 
65                  70                  75                  80  


Ser Ser Cys Cys Pro Phe Pro Glu Ala Val Ala Cys Gly Asp Gly His 
                85                  90                  95      


His Cys Cys Pro Arg Gly Phe His Cys Ser Ala Asp Gly Arg Ser Cys 
            100                 105                 110         


Phe Gln Arg Ser Gly Asn Asn Ser Val Gly Ala Ile Gln Cys Pro Asp 
        115                 120                 125             


Ser Gln Phe Glu Cys Pro Asp Phe Ser Thr Cys Cys Val Met 
    130                 135                 140         


<210>  6257
<211>  149
<212>  PRT
<213>  Homo Sapiens

<400>  6257

Met Trp Thr Leu Val Ser Trp Val Ala Leu Thr Ala Gly Leu Val Ala 
1               5                   10                  15      


Gly Thr Arg Cys Pro Asp Gly Gln Phe Cys Pro Val Ala Cys Cys Leu 
            20                  25                  30          


Asp Pro Gly Gly Ala Ser Tyr Ser Cys Cys Arg Pro Leu Leu Asp Lys 
        35                  40                  45              


Trp Pro Thr Thr Leu Ser Arg His Leu Gly Gly Pro Cys Gln Val Asp 
    50                  55                  60                  


Ala His Cys Ser Ala Gly His Ser Cys Ile Phe Thr Val Ser Gly Thr 
65                  70                  75                  80  


Ser Ser Cys Cys Pro Phe Pro Glu Ala Val Ala Cys Gly Asp Gly His 
                85                  90                  95      


His Cys Cys Pro Arg Gly Phe His Cys Ser Ala Asp Gly Arg Ser Cys 
            100                 105                 110         


Phe Gln Arg Ser Gly Asn Asn Ser Val Gly Ala Ile Gln Cys Pro Asp 
        115                 120                 125             


Ser Gln Phe Glu Cys Pro Asp Phe Ser Thr Cys Cys Val Met Val Asp 
    130                 135                 140                 


Gly Ser Trp Gly Cys 
145                 


<210>  6258
<211>  163
<212>  PRT
<213>  Homo Sapiens

<400>  6258

Met Trp Thr Leu Val Ser Trp Val Ala Leu Thr Ala Gly Leu Val Ala 
1               5                   10                  15      


Gly Thr Arg Cys Pro Asp Gly Gln Phe Cys Pro Val Ala Cys Cys Leu 
            20                  25                  30          


Asp Pro Gly Gly Ala Ser Tyr Ser Cys Cys Arg Pro Leu Leu Asp Lys 
        35                  40                  45              


Trp Pro Thr Thr Leu Ser Arg His Leu Gly Gly Pro Cys Gln Val Asp 
    50                  55                  60                  


Ala His Cys Ser Ala Gly His Ser Cys Ile Phe Thr Val Ser Gly Thr 
65                  70                  75                  80  


Ser Ser Cys Cys Pro Phe Pro Glu Ala Val Ala Cys Gly Asp Gly His 
                85                  90                  95      


His Cys Cys Pro Arg Gly Phe His Cys Ser Ala Asp Gly Arg Ser Cys 
            100                 105                 110         


Phe Gln Arg Ser Gly Asn Asn Ser Val Gly Ala Ile Gln Cys Pro Asp 
        115                 120                 125             


Ser Gln Phe Glu Cys Pro Asp Phe Ser Thr Cys Cys Val Met Val Asp 
    130                 135                 140                 


Gly Ser Trp Gly Cys Cys Pro Met Pro Gln Ala Ser Cys Cys Glu Asp 
145                 150                 155                 160 


Arg Val His 
            


<210>  6259
<211>  593
<212>  PRT
<213>  Homo Sapiens

<400>  6259

Met Trp Thr Leu Val Ser Trp Val Ala Leu Thr Ala Gly Leu Val Ala 
1               5                   10                  15      


Gly Thr Arg Cys Pro Asp Gly Gln Phe Cys Pro Val Ala Cys Cys Leu 
            20                  25                  30          


Asp Pro Gly Gly Ala Ser Tyr Ser Cys Cys Arg Pro Leu Leu Asp Lys 
        35                  40                  45              


Trp Pro Thr Thr Leu Ser Arg His Leu Gly Gly Pro Cys Gln Val Asp 
    50                  55                  60                  


Ala His Cys Ser Ala Gly His Ser Cys Ile Phe Thr Val Ser Gly Thr 
65                  70                  75                  80  


Ser Ser Cys Cys Pro Phe Pro Glu Ala Val Ala Cys Gly Asp Gly His 
                85                  90                  95      


His Cys Cys Pro Arg Gly Phe His Cys Ser Ala Asp Gly Arg Ser Cys 
            100                 105                 110         


Phe Gln Arg Ser Gly Asn Asn Ser Val Gly Ala Ile Gln Cys Pro Asp 
        115                 120                 125             


Ser Gln Phe Glu Cys Pro Asp Phe Ser Thr Cys Cys Val Met Val Asp 
    130                 135                 140                 


Gly Ser Trp Gly Cys Cys Pro Met Pro Gln Ala Ser Cys Cys Glu Asp 
145                 150                 155                 160 


Arg Val His Cys Cys Pro His Gly Ala Phe Cys Asp Leu Val His Thr 
                165                 170                 175     


Arg Cys Ile Thr Pro Thr Gly Thr His Pro Leu Ala Lys Lys Leu Pro 
            180                 185                 190         


Ala Gln Arg Thr Asn Arg Ala Val Ala Leu Ser Ser Ser Val Met Cys 
        195                 200                 205             


Pro Asp Ala Arg Ser Arg Cys Pro Asp Gly Ser Thr Cys Cys Glu Leu 
    210                 215                 220                 


Pro Ser Gly Lys Tyr Gly Cys Cys Pro Met Pro Asn Ala Thr Cys Cys 
225                 230                 235                 240 


Ser Asp His Leu His Cys Cys Pro Gln Asp Thr Val Cys Asp Leu Ile 
                245                 250                 255     


Gln Ser Lys Cys Leu Ser Lys Glu Asn Ala Thr Thr Asp Leu Leu Thr 
            260                 265                 270         


Lys Leu Pro Ala His Thr Val Gly Asp Val Lys Cys Asp Met Glu Val 
        275                 280                 285             


Ser Cys Pro Asp Gly Tyr Thr Cys Cys Arg Leu Gln Ser Gly Ala Trp 
    290                 295                 300                 


Gly Cys Cys Pro Phe Thr Gln Ala Val Cys Cys Glu Asp His Ile His 
305                 310                 315                 320 


Cys Cys Pro Ala Gly Phe Thr Cys Asp Thr Gln Lys Gly Thr Cys Glu 
                325                 330                 335     


Gln Gly Pro His Gln Val Pro Trp Met Glu Lys Ala Pro Ala His Leu 
            340                 345                 350         


Ser Leu Pro Asp Pro Gln Ala Leu Lys Arg Asp Val Pro Cys Asp Asn 
        355                 360                 365             


Val Ser Ser Cys Pro Ser Ser Asp Thr Cys Cys Gln Leu Thr Ser Gly 
    370                 375                 380                 


Glu Trp Gly Cys Cys Pro Ile Pro Glu Ala Val Cys Cys Ser Asp His 
385                 390                 395                 400 


Gln His Cys Cys Pro Gln Gly Tyr Thr Cys Val Ala Glu Gly Gln Cys 
                405                 410                 415     


Gln Arg Gly Ser Glu Ile Val Ala Gly Leu Glu Lys Met Pro Ala Arg 
            420                 425                 430         


Arg Ala Ser Leu Ser His Pro Arg Asp Ile Gly Cys Asp Gln His Thr 
        435                 440                 445             


Ser Cys Pro Val Gly Gln Thr Cys Cys Pro Ser Leu Gly Gly Ser Trp 
    450                 455                 460                 


Ala Cys Cys Gln Leu Pro His Ala Val Cys Cys Glu Asp Arg Gln His 
465                 470                 475                 480 


Cys Cys Pro Ala Gly Tyr Thr Cys Asn Val Lys Ala Arg Ser Cys Glu 
                485                 490                 495     


Lys Glu Val Val Ser Ala Gln Pro Ala Thr Phe Leu Ala Arg Ser Pro 
            500                 505                 510         


His Val Gly Val Lys Asp Val Glu Cys Gly Glu Gly His Phe Cys His 
        515                 520                 525             


Asp Asn Gln Thr Cys Cys Arg Asp Asn Arg Gln Gly Trp Ala Cys Cys 
    530                 535                 540                 


Pro Tyr Arg Gln Gly Val Cys Cys Ala Asp Arg Arg His Cys Cys Pro 
545                 550                 555                 560 


Ala Gly Phe Arg Cys Ala Ala Arg Gly Thr Lys Cys Leu Arg Arg Glu 
                565                 570                 575     


Ala Pro Arg Trp Asp Ala Pro Leu Arg Asp Pro Ala Leu Arg Gln Leu 
            580                 585                 590         


Leu 
    


<210>  6260
<211>  438
<212>  PRT
<213>  Homo Sapiens

<400>  6260

Met Trp Thr Leu Val Ser Trp Val Ala Leu Thr Ala Gly Leu Val Ala 
1               5                   10                  15      


Gly Thr Arg Cys Pro Asp Gly Gln Phe Cys Pro Val Ala Cys Cys Leu 
            20                  25                  30          


Asp Pro Gly Gly Ala Ser Tyr Ser Cys Cys Arg Pro Leu Leu Asp Lys 
        35                  40                  45              


Trp Pro Thr Thr Leu Ser Arg His Leu Gly Gly Pro Cys Gln Val Asp 
    50                  55                  60                  


Ala His Cys Ser Ala Gly His Ser Cys Ile Phe Thr Val Ser Gly Thr 
65                  70                  75                  80  


Ser Ser Cys Cys Pro Phe Pro Glu Ala Val Ala Cys Gly Asp Gly His 
                85                  90                  95      


His Cys Cys Pro Arg Gly Phe His Cys Ser Ala Asp Gly Arg Ser Cys 
            100                 105                 110         


Phe Gln Arg Ser Gly Asn Asn Ser Val Gly Ala Ile Gln Cys Pro Asp 
        115                 120                 125             


Ser Gln Phe Glu Cys Pro Asp Phe Ser Thr Cys Cys Val Met Val Asp 
    130                 135                 140                 


Gly Ser Trp Gly Cys Cys Pro Met Pro Gln Ala Ser Cys Cys Glu Asp 
145                 150                 155                 160 


Arg Val His Cys Cys Pro His Gly Ala Phe Cys Asp Leu Val His Thr 
                165                 170                 175     


Arg Cys Ile Thr Pro Thr Gly Thr His Pro Leu Ala Lys Lys Leu Pro 
            180                 185                 190         


Ala Gln Arg Thr Asn Arg Ala Val Ala Leu Ser Ser Ser Val Met Cys 
        195                 200                 205             


Pro Asp Ala Arg Ser Arg Cys Pro Asp Gly Ser Thr Cys Cys Glu Leu 
    210                 215                 220                 


Pro Ser Gly Lys Tyr Gly Cys Cys Pro Met Pro Asn Ala Thr Cys Cys 
225                 230                 235                 240 


Ser Asp His Leu His Cys Cys Pro Gln Asp Thr Val Cys Asp Leu Ile 
                245                 250                 255     


Gln Ser Lys Cys Leu Ser Lys Glu Asn Ala Thr Thr Asp Leu Leu Thr 
            260                 265                 270         


Lys Leu Pro Ala His Thr Val Gly Asp Val Lys Cys Asp Met Glu Val 
        275                 280                 285             


Ser Cys Pro Asp Gly Tyr Thr Cys Cys Arg Leu Gln Ser Gly Ala Trp 
    290                 295                 300                 


Gly Cys Cys Pro Phe Thr Gln Ala Val Cys Cys Glu Asp His Ile His 
305                 310                 315                 320 


Cys Cys Pro Ala Gly Phe Thr Cys Asp Thr Gln Lys Gly Thr Cys Glu 
                325                 330                 335     


Gln Gly Pro His Gln Val Pro Trp Met Glu Lys Ala Pro Ala His Leu 
            340                 345                 350         


Ser Leu Pro Asp Pro Gln Ala Leu Lys Arg Asp Val Pro Cys Asp Asn 
        355                 360                 365             


Val Ser Ser Cys Pro Ser Ser Asp Thr Cys Cys Arg Asp Asn Arg Gln 
    370                 375                 380                 


Gly Trp Ala Cys Cys Pro Tyr Arg Gln Gly Val Cys Cys Ala Asp Arg 
385                 390                 395                 400 


Arg His Cys Cys Pro Ala Gly Phe Arg Cys Ala Ala Arg Gly Thr Lys 
                405                 410                 415     


Cys Leu Arg Arg Glu Ala Pro Arg Trp Asp Ala Pro Leu Arg Asp Pro 
            420                 425                 430         


Ala Leu Arg Gln Leu Leu 
        435             


<210>  6261
<211>  436
<212>  PRT
<213>  Homo Sapiens

<400>  6261

Met Trp Thr Leu Val Ser Trp Val Ala Leu Thr Ala Gly Leu Val Ala 
1               5                   10                  15      


Gly Thr Arg Cys Pro Asp Gly Gln Phe Cys Pro Val Ala Cys Cys Leu 
            20                  25                  30          


Asp Pro Gly Gly Ala Ser Tyr Ser Cys Cys Arg Pro Leu Leu Asp Lys 
        35                  40                  45              


Trp Pro Thr Thr Leu Ser Arg His Leu Gly Gly Pro Cys Gln Val Asp 
    50                  55                  60                  


Ala His Cys Ser Ala Gly His Ser Cys Ile Phe Thr Val Ser Gly Thr 
65                  70                  75                  80  


Ser Ser Cys Cys Pro Phe Pro Glu Ala Val Ala Cys Gly Asp Gly His 
                85                  90                  95      


His Cys Cys Pro Arg Gly Phe His Cys Ser Ala Asp Gly Arg Ser Cys 
            100                 105                 110         


Phe Gln Arg Ser Gly Asn Asn Ser Val Gly Ala Ile Gln Cys Pro Asp 
        115                 120                 125             


Ser Gln Phe Glu Cys Pro Asp Phe Ser Thr Cys Cys Val Met Val Asp 
    130                 135                 140                 


Gly Ser Trp Gly Cys Cys Pro Met Pro Gln Ala Val Cys Cys Glu Asp 
145                 150                 155                 160 


His Ile His Cys Cys Pro Ala Gly Phe Thr Cys Asp Thr Gln Lys Gly 
                165                 170                 175     


Thr Cys Glu Gln Gly Pro His Gln Val Pro Trp Met Glu Lys Ala Pro 
            180                 185                 190         


Ala His Leu Ser Leu Pro Asp Pro Gln Ala Leu Lys Arg Asp Val Pro 
        195                 200                 205             


Cys Asp Asn Val Ser Ser Cys Pro Ser Ser Asp Thr Cys Cys Gln Leu 
    210                 215                 220                 


Thr Ser Gly Glu Trp Gly Cys Cys Pro Ile Pro Glu Ala Val Cys Cys 
225                 230                 235                 240 


Ser Asp His Gln His Cys Cys Pro Gln Gly Tyr Thr Cys Val Ala Glu 
                245                 250                 255     


Gly Gln Cys Gln Arg Gly Ser Glu Ile Val Ala Gly Leu Glu Lys Met 
            260                 265                 270         


Pro Ala Arg Arg Ala Ser Leu Ser His Pro Arg Asp Ile Gly Cys Asp 
        275                 280                 285             


Gln His Thr Ser Cys Pro Val Gly Gln Thr Cys Cys Pro Ser Leu Gly 
    290                 295                 300                 


Gly Ser Trp Ala Cys Cys Gln Leu Pro His Ala Val Cys Cys Glu Asp 
305                 310                 315                 320 


Arg Gln His Cys Cys Pro Ala Gly Tyr Thr Cys Asn Val Lys Ala Arg 
                325                 330                 335     


Ser Cys Glu Lys Glu Val Val Ser Ala Gln Pro Ala Thr Phe Leu Ala 
            340                 345                 350         


Arg Ser Pro His Val Gly Val Lys Asp Val Glu Cys Gly Glu Gly His 
        355                 360                 365             


Phe Cys His Asp Asn Gln Thr Cys Cys Arg Asp Asn Arg Gln Gly Trp 
    370                 375                 380                 


Ala Cys Cys Pro Tyr Arg Gln Gly Val Cys Cys Ala Asp Arg Arg His 
385                 390                 395                 400 


Cys Cys Pro Ala Gly Phe Arg Cys Ala Ala Arg Gly Thr Lys Cys Leu 
                405                 410                 415     


Arg Arg Glu Ala Pro Arg Trp Asp Ala Pro Leu Arg Asp Pro Ala Leu 
            420                 425                 430         


Arg Gln Leu Leu 
        435     


<210>  6262
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  6262

Met Trp Thr Leu Val Ser Trp Val Ala Leu Thr Ala Gly Leu Val Ala 
1               5                   10                  15      


Gly Thr Arg Cys Pro Asp Gly Gln Phe Cys Pro Val Ala Cys Cys Leu 
            20                  25                  30          


Asp Pro Gly Gly Ala Ser Tyr Ser Cys Cys Arg Pro Leu Leu Asp Lys 
        35                  40                  45              


Trp Pro Thr Thr Leu Ser Arg His Leu Gly Gly Pro Cys Gln Val Asp 
    50                  55                  60                  


Ala His Cys Ser Ala Gly His Ser Cys Ile Phe Thr Val Ser Gly Thr 
65                  70                  75                  80  


Ser Ser Cys Cys Pro Phe Pro Glu Ala Val Ala Cys Gly Asp Gly His 
                85                  90                  95      


His Cys Cys Pro Arg Gly Phe His Cys Ser Ala Asp Gly Arg Ser Cys 
            100                 105                 110         


Phe Gln Arg Ser Gly Asn Asn Ser Val Gly Ala Ile Gln Cys Pro Asp 
        115                 120                 125             


Ser Gln Phe Glu Cys Pro Asp Phe Ser Thr Cys Cys Val Met Val Asp 
    130                 135                 140                 


Gly Ser Trp Gly Cys Cys Pro Met Pro Gln Gly Ala Leu Leu Ser Ala 
145                 150                 155                 160 


Arg Cys Leu Leu Arg Pro Gly Ser His Pro Leu His His Thr His Gly 
                165                 170                 175     


His Pro Pro Pro Gly Lys Glu Ala Pro Cys Pro Glu Asp 
            180                 185                 


<210>  6263
<211>  191
<212>  PRT
<213>  Homo Sapiens

<400>  6263

Met Trp Thr Leu Val Ser Trp Val Ala Leu Thr Ala Gly Leu Val Ala 
1               5                   10                  15      


Gly Thr Arg Cys Pro Asp Gly Gln Phe Cys Pro Val Ala Cys Cys Leu 
            20                  25                  30          


Asp Pro Gly Gly Ala Ser Tyr Ser Cys Cys Arg Pro Leu Leu Asp Lys 
        35                  40                  45              


Trp Pro Thr Thr Leu Ser Arg His Leu Gly Gly Pro Cys Gln Val Asp 
    50                  55                  60                  


Ala His Cys Ser Ala Gly His Ser Cys Ile Phe Thr Val Ser Gly Thr 
65                  70                  75                  80  


Ser Ser Cys Cys Pro Phe Pro Glu Ile Lys Gly Pro Cys Gln Cys Arg 
                85                  90                  95      


Phe Leu Cys Val Pro Gln Ala Val Ala Cys Gly Asp Gly His His Cys 
            100                 105                 110         


Cys Pro Arg Gly Phe His Cys Ser Ala Asp Gly Arg Ser Cys Phe Gln 
        115                 120                 125             


Arg Ser Gly Asn Asn Ser Val Gly Ala Ile Gln Cys Pro Asp Ser Gln 
    130                 135                 140                 


Phe Glu Cys Pro Asp Phe Ser Thr Cys Cys Val Met Val Asp Gly Ser 
145                 150                 155                 160 


Trp Gly Cys Cys Pro Met Pro Gln Ala Ser Cys Cys Glu Asp Arg Val 
                165                 170                 175     


His Cys Cys Pro His Gly Ala Phe Cys Asp Leu Val His Thr Arg 
            180                 185                 190     


<210>  6264
<211>  388
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6264

Xaa Ala Lys Lys Leu Pro Ala Gln Arg Thr Asn Arg Ala Val Ala Leu 
1               5                   10                  15      


Ser Ser Ser Val Met Cys Pro Asp Ala Arg Ser Arg Cys Pro Asp Gly 
            20                  25                  30          


Ser Thr Cys Cys Glu Leu Pro Ser Gly Lys Tyr Gly Cys Cys Pro Met 
        35                  40                  45              


Pro Asn Ala Thr Cys Cys Ser Asp His Leu His Cys Cys Pro Gln Asp 
    50                  55                  60                  


Thr Val Cys Asp Leu Ile Gln Ser Lys Cys Leu Ser Lys Glu Asn Ala 
65                  70                  75                  80  


Thr Thr Asp Leu Leu Thr Lys Leu Pro Ala His Thr Val Gly Asp Val 
                85                  90                  95      


Lys Cys Asp Met Glu Val Ser Cys Pro Asp Gly Tyr Thr Cys Cys Arg 
            100                 105                 110         


Leu Gln Ser Gly Ala Trp Gly Cys Cys Pro Phe Thr Gln Ala Val Cys 
        115                 120                 125             


Cys Glu Asp His Ile His Cys Cys Pro Ala Gly Phe Thr Cys Asp Thr 
    130                 135                 140                 


Gln Lys Gly Thr Cys Glu Gln Gly Pro His Gln Val Pro Trp Met Glu 
145                 150                 155                 160 


Lys Ala Pro Ala His Leu Ser Leu Pro Asp Pro Gln Ala Leu Lys Arg 
                165                 170                 175     


Asp Val Pro Cys Asp Asn Val Ser Ser Cys Pro Ser Ser Asp Thr Cys 
            180                 185                 190         


Cys Gln Leu Thr Ser Gly Glu Trp Gly Cys Cys Pro Ile Pro Glu Ala 
        195                 200                 205             


Val Cys Cys Ser Asp His Gln His Cys Cys Pro Gln Gly Tyr Thr Cys 
    210                 215                 220                 


Val Ala Glu Gly Gln Cys Gln Arg Gly Ser Glu Ile Val Ala Gly Leu 
225                 230                 235                 240 


Glu Lys Met Pro Ala Arg Arg Ala Ser Leu Ser His Pro Arg Asp Ile 
                245                 250                 255     


Gly Cys Asp Gln His Thr Ser Cys Pro Val Gly Gln Thr Cys Cys Pro 
            260                 265                 270         


Ser Leu Gly Gly Ser Trp Ala Cys Cys Gln Leu Pro His Ala Val Cys 
        275                 280                 285             


Cys Glu Asp Arg Gln His Cys Cys Pro Ala Gly Tyr Thr Cys Asn Val 
    290                 295                 300                 


Lys Ala Arg Ser Cys Glu Lys Glu Val Val Ser Ala Gln Pro Ala Thr 
305                 310                 315                 320 


Phe Leu Ala Arg Ser Pro His Val Gly Val Lys Asp Val Glu Cys Gly 
                325                 330                 335     


Glu Gly His Phe Cys His Asp Asn Gln Thr Cys Cys Arg Asp Asn Arg 
            340                 345                 350         


Gln Gly Trp Ala Cys Cys Pro Tyr Arg Gln Val Ser Ala Asn Pro His 
        355                 360                 365             


Pro Gly Ala Gly Tyr Gly Gln Gly Pro Gly Pro Thr Ser Ser Asn Pro 
    370                 375                 380                 


Leu Ala Pro Leu 
385             


<210>  6265
<211>  110
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6265

Xaa Cys Pro Ser Leu Gly Gly Ser Trp Ala Cys Cys Gln Leu Pro His 
1               5                   10                  15      


Ala Val Cys Cys Glu Asp Arg Gln His Cys Cys Pro Ala Gly Tyr Thr 
            20                  25                  30          


Cys Asn Val Lys Ala Arg Ser Cys Glu Lys Glu Val Val Ser Ala Gln 
        35                  40                  45              


Pro Ala Thr Phe Leu Ala Arg Ser Pro His Val Gly Val Lys Asp Val 
    50                  55                  60                  


Glu Cys Gly Glu Gly His Phe Cys His Asp Asn Gln Thr Cys Cys Arg 
65                  70                  75                  80  


Asp Asn Arg Gln Gly Trp Ala Cys Cys Pro Tyr Arg Gln Pro Gly Val 
                85                  90                  95      


Pro Ser Val Cys Ala Gly Arg Pro Arg Ala Gly Thr Pro Leu 
            100                 105                 110 


<210>  6266
<211>  138
<212>  PRT
<213>  Homo Sapiens

<400>  6266

Met Arg Gly Arg Glu Leu Pro Leu Val Leu Leu Ala Leu Val Leu Cys 
1               5                   10                  15      


Leu Ala Pro Arg Gly Arg Ala Val Pro Leu Pro Ala Gly Gly Gly Thr 
            20                  25                  30          


Val Leu Thr Lys Met Tyr Pro Arg Gly Asn His Trp Ala Val Gly His 
        35                  40                  45              


Leu Met Gly Lys Lys Ser Thr Gly Glu Ser Ser Ser Val Ser Glu Arg 
    50                  55                  60                  


Gly Ser Leu Lys Gln Gln Leu Arg Glu Tyr Ile Arg Trp Glu Glu Ala 
65                  70                  75                  80  


Ala Arg Asn Leu Leu Gly Leu Ile Glu Ala Lys Glu Asn Arg Asn His 
                85                  90                  95      


Gln Pro Pro Gln Pro Lys Ala Leu Gly Asn Gln Gln Pro Ser Trp Asp 
            100                 105                 110         


Ser Glu Asp Ser Ser Asn Phe Lys Asp Leu Val Asp Ser Leu Leu Gln 
        115                 120                 125             


Val Leu Asn Val Lys Glu Gly Thr Pro Ser 
    130                 135             


<210>  6267
<211>  141
<212>  PRT
<213>  Homo Sapiens

<400>  6267

Met Arg Gly Arg Glu Leu Pro Leu Val Leu Leu Ala Leu Val Leu Cys 
1               5                   10                  15      


Leu Ala Pro Arg Gly Arg Ala Val Pro Leu Pro Ala Gly Gly Gly Thr 
            20                  25                  30          


Val Leu Thr Lys Met Tyr Pro Arg Gly Asn His Trp Ala Val Gly His 
        35                  40                  45              


Leu Met Gly Lys Lys Ser Thr Gly Glu Ser Ser Ser Val Ser Glu Arg 
    50                  55                  60                  


Gly Ser Leu Lys Gln Gln Leu Arg Glu Tyr Ile Arg Trp Glu Glu Ala 
65                  70                  75                  80  


Ala Arg Asn Leu Leu Gly Leu Ile Glu Ala Lys Glu Asn Arg Asn His 
                85                  90                  95      


Gln Pro Pro Gln Pro Lys Ala Leu Gly Asn Gln Gln Pro Ser Trp Asp 
            100                 105                 110         


Ser Glu Asp Ser Ser Asn Phe Lys Asp Val Gly Ser Lys Gly Lys Gly 
        115                 120                 125             


Ser Gln Arg Glu Gly Arg Asn Pro Gln Leu Asn Gln Gln 
    130                 135                 140     


<210>  6268
<211>  148
<212>  PRT
<213>  Homo Sapiens

<400>  6268

Met Arg Gly Arg Glu Leu Pro Leu Val Leu Leu Ala Leu Val Leu Cys 
1               5                   10                  15      


Leu Ala Pro Arg Gly Arg Ala Val Pro Leu Pro Ala Gly Gly Gly Thr 
            20                  25                  30          


Val Leu Thr Lys Met Tyr Pro Arg Gly Asn His Trp Ala Val Gly His 
        35                  40                  45              


Leu Met Gly Lys Lys Ser Thr Gly Glu Ser Ser Ser Val Ser Glu Arg 
    50                  55                  60                  


Gly Ser Leu Lys Gln Gln Leu Arg Glu Tyr Ile Arg Trp Glu Glu Ala 
65                  70                  75                  80  


Ala Arg Asn Leu Leu Gly Leu Ile Glu Ala Lys Glu Asn Arg Asn His 
                85                  90                  95      


Gln Pro Pro Gln Pro Lys Ala Leu Gly Asn Gln Gln Pro Ser Trp Asp 
            100                 105                 110         


Ser Glu Asp Ser Ser Asn Phe Lys Asp Val Gly Ser Lys Gly Lys Val 
        115                 120                 125             


Gly Arg Leu Ser Ala Pro Gly Ser Gln Arg Glu Gly Arg Asn Pro Gln 
    130                 135                 140                 


Leu Asn Gln Gln 
145             


<210>  6269
<211>  96
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6269

Xaa His Leu Met Gly Lys Lys Ser Thr Gly Glu Ser Ser Ser Val Ser 
1               5                   10                  15      


Glu Arg Gly Ser Leu Lys Gln Gln Leu Arg Glu Tyr Ile Arg Trp Glu 
            20                  25                  30          


Glu Ala Ala Arg Asn Leu Leu Gly Leu Ile Glu Ala Lys Glu Asn Arg 
        35                  40                  45              


Asn His Gln Pro Pro Gln Pro Lys Ala Leu Gly Asn Gln Gln Pro Ser 
    50                  55                  60                  


Trp Asp Ser Glu Asp Ser Ser Asn Phe Lys Asp Val Gly Ser Lys Gly 
65                  70                  75                  80  


Lys Asp Ser Leu Leu Gln Val Leu Asn Val Lys Glu Gly Thr Pro Ser 
                85                  90                  95      


<210>  6270
<211>  35
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6270

Xaa Ile Ser Ser Leu Arg Gly Ile Gln Arg Ile Ala Ala Thr Ser Lys 
1               5                   10                  15      


Ile Leu Ser Ala Pro Gly Ser Gln Arg Glu Gly Arg Asn Pro Gln Leu 
            20                  25                  30          


Asn Gln Gln 
        35  


<210>  6271
<211>  496
<212>  PRT
<213>  Homo Sapiens

<400>  6271

Met Phe Ala Lys Ala Thr Arg Asn Phe Leu Arg Glu Val Asp Ala Asp 
1               5                   10                  15      


Gly Asp Leu Ile Ala Val Ser Asn Leu Asn Asp Ser Asp Lys Leu Gln 
            20                  25                  30          


Leu Leu Ser Leu Val Thr Lys Lys Lys Arg Phe Trp Cys Trp Gln Arg 
        35                  40                  45              


Pro Lys Tyr Gln Phe Leu Ser Leu Thr Leu Gly Asp Val Leu Ile Glu 
    50                  55                  60                  


Asp Gln Phe Pro Ser Pro Val Val Val Glu Ser Asp Phe Val Lys Tyr 
65                  70                  75                  80  


Glu Gly Lys Phe Ala Asn His Val Ser Gly Thr Leu Glu Thr Ala Leu 
                85                  90                  95      


Gly Lys Val Lys Leu Asn Leu Gly Gly Ser Ser Arg Val Glu Ser Gln 
            100                 105                 110         


Ser Ser Phe Gly Thr Leu Arg Lys Gln Glu Val Asp Leu Gln Gln Leu 
        115                 120                 125             


Ile Arg Asp Ser Ala Glu Arg Thr Ile Asn Leu Arg Asn Pro Val Leu 
    130                 135                 140                 


Gln Gln Val Leu Glu Gly Arg Asn Glu Val Leu Cys Val Leu Thr Gln 
145                 150                 155                 160 


Lys Ile Thr Thr Met Gln Lys Cys Val Ile Ser Glu His Met Gln Val 
                165                 170                 175     


Glu Glu Lys Cys Gly Gly Ile Val Gly Ile Gln Thr Lys Thr Val Gln 
            180                 185                 190         


Val Ser Ala Thr Glu Asp Gly Asn Val Thr Lys Asp Ser Asn Val Val 
        195                 200                 205             


Leu Glu Ile Pro Ala Ala Thr Thr Ile Ala Tyr Gly Val Ile Glu Leu 
    210                 215                 220                 


Tyr Val Lys Leu Asp Gly Gln Phe Glu Phe Cys Leu Leu Arg Gly Lys 
225                 230                 235                 240 


Gln Gly Gly Phe Glu Asn Lys Lys Arg Ile Asp Ser Val Tyr Leu Asp 
                245                 250                 255     


Pro Leu Val Phe Arg Glu Phe Ala Phe Ile Asp Met Pro Asp Ala Ala 
            260                 265                 270         


His Gly Ile Ser Ser Gln Asp Gly Pro Leu Ser Val Leu Lys Gln Ala 
        275                 280                 285             


Thr Leu Leu Leu Glu Arg Asn Phe His Pro Phe Ala Glu Leu Pro Glu 
    290                 295                 300                 


Pro Gln Gln Thr Ala Leu Ser Asp Ile Phe Gln Ala Val Leu Phe Asp 
305                 310                 315                 320 


Asp Glu Leu Leu Met Val Leu Glu Pro Val Cys Asp Asp Leu Val Ser 
                325                 330                 335     


Gly Leu Ser Pro Thr Val Ala Val Leu Gly Glu Leu Lys Pro Arg Gln 
            340                 345                 350         


Gln Gln Asp Leu Val Ala Phe Leu Gln Leu Val Gly Cys Ser Leu Gln 
        355                 360                 365             


Gly Gly Cys Pro Gly Pro Glu Asp Ala Gly Ser Lys Gln Leu Phe Met 
    370                 375                 380                 


Thr Ala Tyr Phe Leu Val Ser Ala Leu Ala Glu Met Pro Asp Ser Ala 
385                 390                 395                 400 


Ala Ala Leu Leu Gly Thr Cys Cys Lys Leu Gln Ile Ile Pro Thr Leu 
                405                 410                 415     


Cys His Leu Leu Arg Ala Leu Ser Asp Asp Gly Val Ser Asp Leu Glu 
            420                 425                 430         


Asp Pro Thr Leu Thr Pro Leu Lys Asp Thr Glu Arg Phe Gly Ile Val 
        435                 440                 445             


Gln Arg Leu Phe Ala Ser Ala Asp Ile Ser Leu Glu Arg Leu Lys Ser 
    450                 455                 460                 


Ser Val Lys Ala Val Ile Leu Lys Asp Ser Lys Val Phe Pro Leu Leu 
465                 470                 475                 480 


Leu Cys Ile Thr Leu Asn Gly Leu Cys Ala Leu Gly Arg Glu His Ser 
                485                 490                 495     


<210>  6272
<211>  356
<212>  PRT
<213>  Homo Sapiens

<400>  6272

Met Phe Ala Lys Ala Thr Arg Asn Phe Leu Arg Glu Val Asp Ala Asp 
1               5                   10                  15      


Gly Asp Leu Ile Ala Val Ser Asn Leu Asn Asp Ser Asp Lys Leu Gln 
            20                  25                  30          


Leu Leu Ser Leu Val Thr Lys Lys Lys Arg Phe Trp Cys Trp Gln Arg 
        35                  40                  45              


Pro Lys Tyr Gln Phe Leu Ser Leu Thr Leu Gly Asp Val Leu Ile Glu 
    50                  55                  60                  


Asp Gln Phe Pro Ser Pro Val Val Val Glu Ser Asp Phe Val Lys Tyr 
65                  70                  75                  80  


Glu Gly Lys Phe Ala Asn His Val Ser Gly Thr Leu Glu Thr Ala Leu 
                85                  90                  95      


Gly Lys Val Lys Leu Asn Leu Gly Gly Ser Ser Arg Val Glu Ser Gln 
            100                 105                 110         


Ser Ser Phe Gly Thr Leu Arg Lys Gln Glu Val Asp Leu Gln Gln Leu 
        115                 120                 125             


Ile Arg Asp Ser Ala Glu Arg Thr Ile Asn Leu Arg Asn Pro Val Leu 
    130                 135                 140                 


Gln Gln Val Leu Glu Gly Arg Asn Glu Val Leu Cys Val Leu Thr Gln 
145                 150                 155                 160 


Lys Ile Thr Thr Met Gln Lys Cys Val Ile Ser Glu His Met Gln Val 
                165                 170                 175     


Glu Glu Lys Cys Gly Gly Ile Val Gly Ile Gln Thr Lys Thr Val Gln 
            180                 185                 190         


Val Ser Ala Thr Glu Asp Gly Asn Val Thr Lys Asp Ser Asn Val Val 
        195                 200                 205             


Leu Glu Ile Pro Ala Ala Thr Thr Ile Ala Tyr Gly Val Ile Glu Leu 
    210                 215                 220                 


Tyr Val Lys Leu Asp Gly Gln Phe Glu Phe Cys Leu Leu Arg Gly Lys 
225                 230                 235                 240 


Gln Gly Gly Phe Glu Asn Lys Lys Arg Ile Asp Ser Val Tyr Leu Asp 
                245                 250                 255     


Pro Leu Val Phe Arg Glu Phe Ala Phe Ile Asp Met Pro Asp Ala Ala 
            260                 265                 270         


His Gly Ile Ser Ser Gln Asp Gly Pro Leu Ser Val Leu Lys Gln Ala 
        275                 280                 285             


Thr Leu Leu Leu Glu Arg Asn Phe His Pro Phe Ala Glu Leu Pro Glu 
    290                 295                 300                 


Pro Gln Gln Thr Ala Leu Ser Asp Ile Phe Gln Ala Val Leu Phe Asp 
305                 310                 315                 320 


Asp Glu Leu Leu Met Val Leu Glu Pro Val Val Ser Pro Glu Thr Ser 
                325                 330                 335     


Gln Gly Ser Val Phe Thr Gly Val Phe Trp Asn Arg Gly Gly Gly Arg 
            340                 345                 350         


Met Glu Leu Cys 
        355     


<210>  6273
<211>  496
<212>  PRT
<213>  Homo Sapiens

<400>  6273

Met Phe Ala Lys Ala Thr Arg Asn Phe Leu Arg Glu Val Asp Ala Asp 
1               5                   10                  15      


Gly Asp Leu Ile Ala Val Ser Asn Leu Asn Asp Ser Asp Lys Leu Gln 
            20                  25                  30          


Leu Leu Ser Leu Val Thr Lys Lys Lys Arg Phe Trp Cys Trp Gln Arg 
        35                  40                  45              


Pro Lys Tyr Gln Phe Leu Ser Leu Thr Leu Gly Asp Val Leu Ile Glu 
    50                  55                  60                  


Asp Gln Phe Pro Ser Pro Val Val Val Glu Ser Asp Phe Val Lys Tyr 
65                  70                  75                  80  


Glu Gly Lys Phe Ala Asn His Val Ser Gly Thr Leu Glu Thr Ala Leu 
                85                  90                  95      


Gly Lys Val Lys Leu Asn Leu Gly Gly Ser Ser Arg Val Glu Ser Gln 
            100                 105                 110         


Ser Ser Phe Gly Thr Leu Arg Lys Gln Glu Val Asp Leu Gln Gln Leu 
        115                 120                 125             


Ile Arg Asp Ser Ala Glu Arg Thr Ile Asn Leu Arg Asn Pro Val Leu 
    130                 135                 140                 


Gln Gln Val Leu Glu Gly Arg Asn Glu Val Leu Cys Val Leu Thr Gln 
145                 150                 155                 160 


Lys Ile Thr Thr Met Gln Lys Cys Val Ile Ser Glu His Met Gln Val 
                165                 170                 175     


Glu Glu Lys Cys Gly Gly Ile Val Gly Ile Gln Thr Lys Thr Val Gln 
            180                 185                 190         


Val Ser Ala Thr Glu Asp Gly Asn Val Thr Lys Asp Ser Asn Val Val 
        195                 200                 205             


Leu Glu Ile Pro Ala Ala Thr Thr Ile Ala Tyr Gly Val Ile Glu Leu 
    210                 215                 220                 


Tyr Val Lys Leu Asp Gly Gln Phe Glu Phe Cys Leu Leu Arg Gly Lys 
225                 230                 235                 240 


Gln Gly Gly Phe Glu Asn Lys Lys Arg Ile Asp Ser Val Tyr Leu Asp 
                245                 250                 255     


Pro Leu Val Phe Arg Glu Phe Ala Phe Ile Asp Met Pro Asp Ala Ala 
            260                 265                 270         


His Gly Ile Ser Ser Gln Asp Gly Pro Leu Ser Val Leu Lys Gln Ala 
        275                 280                 285             


Thr Leu Leu Leu Glu Arg Asn Phe His Pro Phe Ala Glu Leu Pro Glu 
    290                 295                 300                 


Pro Gln Gln Thr Ala Leu Ser Asp Ile Phe Gln Ala Val Leu Phe Asp 
305                 310                 315                 320 


Asp Glu Leu Leu Met Val Leu Glu Pro Val Cys Asp Asp Leu Val Ser 
                325                 330                 335     


Gly Leu Ser Pro Thr Val Ala Val Leu Gly Glu Leu Lys Pro Arg Gln 
            340                 345                 350         


Gln Gln Asp Leu Val Ala Phe Leu Gln Leu Val Gly Cys Ser Leu Gln 
        355                 360                 365             


Gly Gly Cys Pro Gly Pro Glu Asp Ala Gly Ser Lys Gln Leu Phe Met 
    370                 375                 380                 


Thr Ala Tyr Phe Leu Val Ser Ala Leu Ala Glu Met Pro Asp Ser Ala 
385                 390                 395                 400 


Ala Ala Leu Leu Gly Thr Cys Cys Lys Leu Gln Ile Ile Pro Thr Leu 
                405                 410                 415     


Cys His Leu Leu Arg Ala Leu Ser Asp Asp Gly Val Ser Asp Leu Glu 
            420                 425                 430         


Asp Pro Thr Leu Thr Pro Leu Lys Asp Thr Glu Arg Phe Gly Ile Val 
        435                 440                 445             


Gln Arg Leu Phe Ala Ser Ala Asp Ile Ser Leu Glu Arg Leu Lys Ser 
    450                 455                 460                 


Ser Val Lys Ala Val Ile Leu Lys Asp Ser Lys Val Phe Pro Leu Leu 
465                 470                 475                 480 


Leu Cys Ile Thr Leu Asn Gly Leu Cys Ala Leu Gly Arg Glu His Ser 
                485                 490                 495     


<210>  6274
<211>  496
<212>  PRT
<213>  Homo Sapiens

<400>  6274

Met Phe Ala Lys Ala Thr Arg Asn Phe Leu Arg Glu Val Asp Ala Asp 
1               5                   10                  15      


Gly Asp Leu Ile Ala Val Ser Asn Leu Asn Asp Ser Asp Lys Leu Gln 
            20                  25                  30          


Leu Leu Ser Leu Val Thr Lys Lys Lys Arg Phe Trp Cys Trp Gln Arg 
        35                  40                  45              


Pro Lys Tyr Gln Phe Leu Ser Leu Thr Leu Gly Asp Val Leu Ile Glu 
    50                  55                  60                  


Asp Gln Phe Pro Ser Pro Val Val Val Glu Ser Asp Phe Val Lys Tyr 
65                  70                  75                  80  


Glu Gly Lys Phe Ala Asn His Val Ser Gly Thr Leu Glu Thr Ala Leu 
                85                  90                  95      


Gly Lys Val Lys Leu Asn Leu Gly Gly Ser Ser Arg Val Glu Ser Gln 
            100                 105                 110         


Ser Ser Phe Gly Thr Leu Arg Lys Gln Glu Val Asp Leu Gln Gln Leu 
        115                 120                 125             


Ile Arg Asp Ser Ala Glu Arg Thr Ile Asn Leu Arg Asn Pro Val Leu 
    130                 135                 140                 


Gln Gln Val Leu Glu Gly Arg Asn Glu Val Leu Cys Val Leu Thr Gln 
145                 150                 155                 160 


Lys Ile Thr Thr Met Gln Lys Cys Val Ile Ser Glu His Met Gln Val 
                165                 170                 175     


Glu Glu Lys Cys Gly Gly Ile Val Gly Ile Gln Thr Lys Thr Val Gln 
            180                 185                 190         


Val Ser Ala Thr Glu Asp Gly Asn Val Thr Lys Asp Ser Asn Val Val 
        195                 200                 205             


Leu Glu Ile Pro Ala Ala Thr Thr Ile Ala Tyr Gly Val Ile Glu Leu 
    210                 215                 220                 


Tyr Val Lys Leu Asp Gly Gln Phe Glu Phe Cys Leu Leu Arg Gly Lys 
225                 230                 235                 240 


Gln Gly Gly Phe Glu Asn Lys Lys Arg Ile Asp Ser Val Tyr Leu Asp 
                245                 250                 255     


Pro Leu Val Phe Arg Glu Phe Ala Phe Ile Asp Met Pro Asp Ala Ala 
            260                 265                 270         


His Gly Ile Ser Ser Gln Asp Gly Pro Leu Ser Val Leu Lys Gln Ala 
        275                 280                 285             


Thr Leu Leu Leu Glu Arg Asn Phe His Pro Phe Ala Glu Leu Pro Glu 
    290                 295                 300                 


Pro Gln Gln Thr Ala Leu Ser Asp Ile Phe Gln Ala Val Leu Phe Asp 
305                 310                 315                 320 


Asp Glu Leu Leu Met Val Leu Glu Pro Val Cys Asp Asp Leu Val Ser 
                325                 330                 335     


Gly Leu Ser Pro Thr Val Ala Val Leu Gly Glu Leu Lys Pro Arg Gln 
            340                 345                 350         


Gln Gln Asp Leu Val Ala Phe Leu Gln Leu Val Gly Cys Ser Leu Gln 
        355                 360                 365             


Gly Gly Cys Pro Gly Pro Glu Asp Ala Gly Ser Lys Gln Leu Phe Met 
    370                 375                 380                 


Thr Ala Tyr Phe Leu Val Ser Ala Leu Ala Glu Met Pro Asp Ser Ala 
385                 390                 395                 400 


Ala Ala Leu Leu Gly Thr Cys Cys Lys Leu Gln Ile Ile Pro Thr Leu 
                405                 410                 415     


Cys His Leu Leu Arg Ala Leu Ser Asp Asp Gly Val Ser Asp Leu Glu 
            420                 425                 430         


Asp Pro Thr Leu Thr Pro Leu Lys Asp Thr Glu Arg Phe Gly Ile Val 
        435                 440                 445             


Gln Arg Leu Phe Ala Ser Ala Asp Ile Ser Leu Glu Arg Leu Lys Ser 
    450                 455                 460                 


Ser Val Lys Ala Val Ile Leu Lys Asp Ser Lys Val Phe Pro Leu Leu 
465                 470                 475                 480 


Leu Cys Ile Thr Leu Asn Gly Leu Cys Ala Leu Gly Arg Glu His Ser 
                485                 490                 495     


<210>  6275
<211>  332
<212>  PRT
<213>  Homo Sapiens

<400>  6275

Met Gln Lys Cys Val Ile Ser Glu His Met Gln Val Glu Glu Lys Cys 
1               5                   10                  15      


Gly Gly Ile Val Gly Ile Gln Thr Lys Thr Val Gln Val Ser Ala Thr 
            20                  25                  30          


Glu Asp Gly Asn Val Thr Lys Asp Ser Asn Val Val Leu Glu Ile Pro 
        35                  40                  45              


Ala Ala Thr Thr Ile Ala Tyr Gly Val Ile Glu Leu Tyr Val Lys Leu 
    50                  55                  60                  


Asp Gly Gln Phe Glu Phe Cys Leu Leu Arg Gly Lys Gln Gly Gly Phe 
65                  70                  75                  80  


Glu Asn Lys Lys Arg Ile Asp Ser Val Tyr Leu Asp Pro Leu Val Phe 
                85                  90                  95      


Arg Glu Phe Ala Phe Ile Asp Met Pro Asp Ala Ala His Gly Ile Ser 
            100                 105                 110         


Ser Gln Asp Gly Pro Leu Ser Val Leu Lys Gln Ala Thr Leu Leu Leu 
        115                 120                 125             


Glu Arg Asn Phe His Pro Phe Ala Glu Leu Pro Glu Pro Gln Gln Thr 
    130                 135                 140                 


Ala Leu Ser Asp Ile Phe Gln Ala Val Leu Phe Asp Asp Glu Leu Leu 
145                 150                 155                 160 


Met Val Leu Glu Pro Val Cys Asp Asp Leu Val Ser Gly Leu Ser Pro 
                165                 170                 175     


Thr Val Ala Val Leu Gly Glu Leu Lys Pro Arg Gln Gln Gln Asp Leu 
            180                 185                 190         


Val Ala Phe Leu Gln Leu Val Gly Cys Ser Leu Gln Gly Gly Cys Pro 
        195                 200                 205             


Gly Pro Glu Asp Ala Gly Ser Lys Gln Leu Phe Met Thr Ala Tyr Phe 
    210                 215                 220                 


Leu Val Ser Ala Leu Ala Glu Met Pro Asp Ser Ala Ala Ala Leu Leu 
225                 230                 235                 240 


Gly Thr Cys Cys Lys Leu Gln Ile Ile Pro Thr Leu Cys His Leu Leu 
                245                 250                 255     


Arg Ala Leu Ser Asp Asp Gly Val Ser Asp Leu Glu Asp Pro Thr Leu 
            260                 265                 270         


Thr Pro Leu Lys Asp Thr Glu Arg Phe Gly Ile Val Gln Arg Leu Phe 
        275                 280                 285             


Ala Ser Ala Asp Ile Ser Leu Glu Arg Leu Lys Ser Ser Val Lys Ala 
    290                 295                 300                 


Val Ile Leu Lys Asp Ser Lys Val Phe Pro Leu Leu Leu Cys Ile Thr 
305                 310                 315                 320 


Leu Asn Gly Leu Cys Ala Leu Gly Arg Glu His Ser 
                325                 330         


<210>  6276
<211>  332
<212>  PRT
<213>  Homo Sapiens

<400>  6276

Met Gln Lys Cys Val Ile Ser Glu His Met Gln Val Glu Glu Lys Cys 
1               5                   10                  15      


Gly Gly Ile Val Gly Ile Gln Thr Lys Thr Val Gln Val Ser Ala Thr 
            20                  25                  30          


Glu Asp Gly Asn Val Thr Lys Asp Ser Asn Val Val Leu Glu Ile Pro 
        35                  40                  45              


Ala Ala Thr Thr Ile Ala Tyr Gly Val Ile Glu Leu Tyr Val Lys Leu 
    50                  55                  60                  


Asp Gly Gln Phe Glu Phe Cys Leu Leu Arg Gly Lys Gln Gly Gly Phe 
65                  70                  75                  80  


Glu Asn Lys Lys Arg Ile Asp Ser Val Tyr Leu Asp Pro Leu Val Phe 
                85                  90                  95      


Arg Glu Phe Ala Phe Ile Asp Met Pro Asp Ala Ala His Gly Ile Ser 
            100                 105                 110         


Ser Gln Asp Gly Pro Leu Ser Val Leu Lys Gln Ala Thr Leu Leu Leu 
        115                 120                 125             


Glu Arg Asn Phe His Pro Phe Ala Glu Leu Pro Glu Pro Gln Gln Thr 
    130                 135                 140                 


Ala Leu Ser Asp Ile Phe Gln Ala Val Leu Phe Asp Asp Glu Leu Leu 
145                 150                 155                 160 


Met Val Leu Glu Pro Val Cys Asp Asp Leu Val Ser Gly Leu Ser Pro 
                165                 170                 175     


Thr Val Ala Val Leu Gly Glu Leu Lys Pro Arg Gln Gln Gln Asp Leu 
            180                 185                 190         


Val Ala Phe Leu Gln Leu Val Gly Cys Ser Leu Gln Gly Gly Cys Pro 
        195                 200                 205             


Gly Pro Glu Asp Ala Gly Ser Lys Gln Leu Phe Met Thr Ala Tyr Phe 
    210                 215                 220                 


Leu Val Ser Ala Leu Ala Glu Met Pro Asp Ser Ala Ala Ala Leu Leu 
225                 230                 235                 240 


Gly Thr Cys Cys Lys Leu Gln Ile Ile Pro Thr Leu Cys His Leu Leu 
                245                 250                 255     


Arg Ala Leu Ser Asp Asp Gly Val Ser Asp Leu Glu Asp Pro Thr Leu 
            260                 265                 270         


Thr Pro Leu Lys Asp Thr Glu Arg Phe Gly Ile Val Gln Arg Leu Phe 
        275                 280                 285             


Ala Ser Ala Asp Ile Ser Leu Glu Arg Leu Lys Ser Ser Val Lys Ala 
    290                 295                 300                 


Val Ile Leu Lys Asp Ser Lys Val Phe Pro Leu Leu Leu Cys Ile Thr 
305                 310                 315                 320 


Leu Asn Gly Leu Cys Ala Leu Gly Arg Glu His Ser 
                325                 330         


<210>  6277
<211>  55
<212>  PRT
<213>  Homo Sapiens

<400>  6277

Gln Leu Phe Met Thr Ala Tyr Phe Leu Val Ser Ala Leu Ala Glu Met 
1               5                   10                  15      


Pro Asp Ser Ala Ala Ala Leu Leu Gly Thr Cys Cys Lys Leu Gln Ile 
            20                  25                  30          


Ile Pro Thr Leu Cys His Leu Val Ser Asn Leu Pro Gly Gly Thr Leu 
        35                  40                  45              


Glu Trp Ile Gly Met Gly Lys 
    50                  55  


<210>  6278
<211>  155
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6278

Xaa Ala Ala Thr Thr Ile Ala Tyr Gly Val Ile Glu Leu Tyr Val Lys 
1               5                   10                  15      


Leu Asp Gly Gln Phe Glu Phe Cys Leu Leu Arg Gly Lys Gln Gly Gly 
            20                  25                  30          


Phe Glu Asn Lys Lys Arg Ile Asp Ser Val Tyr Leu Asp Pro Leu Val 
        35                  40                  45              


Phe Arg Glu Phe Ala Phe Ile Asp Met Pro Asp Ala Ala His Gly Ile 
    50                  55                  60                  


Ser Ser Gln Asp Gly Pro Leu Ser Val Leu Lys Gln Ala Thr Leu Leu 
65                  70                  75                  80  


Leu Glu Arg Asn Phe His Pro Phe Ala Glu Leu Pro Glu Pro Gln Gln 
                85                  90                  95      


Thr Ala Leu Ser Asp Ile Phe Gln Ala Val Leu Phe Asp Asp Glu Leu 
            100                 105                 110         


Leu Met Val Leu Glu Pro Val Lys Asp Ile Leu Gly Arg Ser Ser Ser 
        115                 120                 125             


Leu Thr Leu Ser Cys Thr Asn Gly Glu Ser His Thr Ser Cys Gln Pro 
    130                 135                 140                 


Ser Ser His Pro Asp Ser Val Ser Ser Leu Ser 
145                 150                 155 


<210>  6279
<211>  192
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6279

Xaa Glu Glu Lys Cys Gly Gly Ile Val Gly Ile Gln Thr Lys Thr Val 
1               5                   10                  15      


Gln Val Ser Ala Thr Glu Asp Gly Asn Val Thr Lys Asp Ser Asn Val 
            20                  25                  30          


Val Leu Glu Ile Pro Ala Ala Thr Thr Ile Ala Tyr Gly Val Ile Glu 
        35                  40                  45              


Leu Tyr Val Lys Leu Asp Gly Gln Phe Glu Phe Cys Leu Leu Arg Gly 
    50                  55                  60                  


Lys Gln Gly Gly Phe Glu Asn Lys Lys Arg Ile Asp Ser Val Tyr Leu 
65                  70                  75                  80  


Asp Pro Leu Val Phe Arg Glu Phe Ala Phe Ile Asp Met Pro Asp Ala 
                85                  90                  95      


Ala His Gly Ile Ser Ser Gln Asp Gly Pro Leu Ser Val Leu Lys Gln 
            100                 105                 110         


Ala Thr Leu Leu Leu Glu Arg Asn Phe His Pro Phe Ala Glu Leu Pro 
        115                 120                 125             


Glu Pro Gln Gln Thr Ala Leu Ser Asp Ile Phe Gln Ala Val Leu Phe 
    130                 135                 140                 


Asp Asp Glu Leu Leu Met Val Leu Glu Pro Val Gln Lys Asp Ile Leu 
145                 150                 155                 160 


Gly Arg Ser Ser Ser Leu Thr Leu Ser Cys Thr Asn Gly Glu Ser His 
                165                 170                 175     


Thr Ser Cys Gln Pro Ser Ser His Pro Asp Ser Val Ser Ser Leu Ser 
            180                 185                 190         


<210>  6280
<211>  211
<212>  PRT
<213>  Homo Sapiens

<400>  6280

Met Ala Lys Met Glu Leu Ser Lys Ala Phe Ser Gly Gln Arg Thr Leu 
1               5                   10                  15      


Leu Ser Ala Ile Leu Ser Met Leu Ser Leu Ser Phe Ser Thr Thr Ser 
            20                  25                  30          


Leu Leu Ser Asn Tyr Trp Phe Val Gly Thr Gln Lys Val Pro Lys Pro 
        35                  40                  45              


Leu Cys Glu Lys Gly Leu Ala Ala Lys Cys Phe Asp Met Pro Val Ser 
    50                  55                  60                  


Leu Asp Gly Asp Thr Asn Thr Ser Thr Gln Glu Val Val Gln Tyr Asn 
65                  70                  75                  80  


Trp Glu Thr Gly Asp Asp Arg Phe Ser Phe Arg Ser Phe Arg Ser Gly 
                85                  90                  95      


Met Trp Leu Ser Cys Glu Glu Thr Val Glu Glu Pro Ala Lys Ser Glu 
            100                 105                 110         


Met Glu Glu Glu Leu Lys Lys Cys Val Tyr Leu His Leu Tyr Leu Leu 
        115                 120                 125             


Leu Cys His Leu Ala Leu Leu His Pro Gln Ser Trp Lys Gln Phe Arg 
    130                 135                 140                 


Ala Leu Arg Ser Ser Gly Thr Ala Ala Ala Lys Gly Glu Arg Cys Arg 
145                 150                 155                 160 


Ser Phe Ile Glu Leu Thr Pro Pro Ala Lys Arg Gly Glu Lys Gly Leu 
                165                 170                 175     


Leu Glu Phe Ala Thr Leu Gln Gly Pro Cys His Pro Thr Leu Arg Phe 
            180                 185                 190         


Gly Gly Lys Arg Leu Met Glu Lys Ala Ser Leu Pro Ser Pro Pro Leu 
        195                 200                 205             


Gly Leu Cys 
    210     


<210>  6281
<211>  298
<212>  PRT
<213>  Homo Sapiens

<400>  6281

Met Ala Lys Met Glu Leu Ser Lys Ala Phe Ser Gly Gln Arg Thr Leu 
1               5                   10                  15      


Leu Ser Ala Ile Leu Ser Met Leu Ser Leu Ser Phe Ser Thr Thr Ser 
            20                  25                  30          


Leu Leu Ser Asn Tyr Trp Phe Val Gly Thr Gln Lys Val Pro Lys Pro 
        35                  40                  45              


Leu Cys Glu Lys Gly Leu Ala Ala Lys Cys Phe Asp Met Pro Val Ser 
    50                  55                  60                  


Leu Asp Gly Asp Thr Asn Thr Ser Thr Gln Glu Val Val Gln Tyr Asn 
65                  70                  75                  80  


Trp Glu Thr Gly Asp Asp Arg Phe Ser Phe Arg Ser Phe Arg Ser Gly 
                85                  90                  95      


Met Trp Leu Ser Cys Glu Glu Thr Val Glu Glu Pro Ala Leu Leu His 
            100                 105                 110         


Pro Gln Ser Trp Lys Gln Phe Arg Ala Leu Arg Ser Ser Gly Thr Ala 
        115                 120                 125             


Ala Ala Lys Gly Glu Arg Cys Arg Ser Phe Ile Glu Leu Thr Pro Pro 
    130                 135                 140                 


Ala Lys Arg Gly Leu Leu Gly Met Val Ala His Met Met Tyr Ser Gln 
145                 150                 155                 160 


Val Phe Gln Ala Thr Val Asn Leu Gly Pro Glu Asp Trp Arg Pro His 
                165                 170                 175     


Val Trp Asn Tyr Gly Trp Ala Phe Tyr Met Ala Trp Leu Ser Phe Thr 
            180                 185                 190         


Cys Cys Met Ala Ser Ala Val Thr Thr Phe Asn Thr Tyr Thr Arg Met 
        195                 200                 205             


Val Leu Glu Phe Lys Cys Lys His Ser Lys Ser Phe Lys Glu Asn Pro 
    210                 215                 220                 


Asn Cys Leu Pro His His His Gln Cys Phe Pro Arg Arg Leu Ser Ser 
225                 230                 235                 240 


Ala Ala Pro Thr Val Gly Pro Leu Thr Ser Tyr His Gln Tyr His Asn 
                245                 250                 255     


Gln Pro Ile His Ser Val Ser Glu Gly Val Asp Phe Tyr Ser Glu Leu 
            260                 265                 270         


Arg Asn Lys Gly Phe Gln Arg Gly Ala Ser Gln Glu Leu Lys Glu Ala 
        275                 280                 285             


Val Arg Ser Ser Val Glu Glu Glu Gln Cys 
    290                 295             


<210>  6282
<211>  326
<212>  PRT
<213>  Homo Sapiens

<400>  6282

Met Ala Lys Met Glu Leu Ser Lys Ala Phe Ser Gly Gln Arg Thr Leu 
1               5                   10                  15      


Leu Ser Ala Ile Leu Ser Met Leu Ser Leu Ser Phe Ser Thr Thr Ser 
            20                  25                  30          


Leu Leu Ser Asn Tyr Trp Phe Val Gly Thr Gln Lys Val Pro Lys Pro 
        35                  40                  45              


Leu Cys Glu Lys Gly Leu Ala Ala Lys Cys Phe Asp Met Pro Val Ser 
    50                  55                  60                  


Leu Asp Gly Asp Thr Asn Thr Ser Thr Gln Glu Val Val Gln Tyr Asn 
65                  70                  75                  80  


Trp Glu Thr Gly Asp Asp Arg Phe Ser Phe Arg Ser Phe Arg Ser Gly 
                85                  90                  95      


Met Trp Leu Ser Cys Glu Glu Thr Val Glu Glu Pro Gly Glu Arg Cys 
            100                 105                 110         


Arg Ser Phe Ile Glu Leu Thr Pro Pro Ala Lys Arg Glu Ile Leu Trp 
        115                 120                 125             


Leu Ser Leu Gly Thr Gln Ile Thr Tyr Ile Gly Leu Gln Phe Ile Ser 
    130                 135                 140                 


Phe Leu Leu Leu Leu Thr Asp Leu Leu Leu Thr Gly Asn Pro Ala Cys 
145                 150                 155                 160 


Gly Leu Lys Leu Ser Ala Phe Ala Ala Val Ser Ser Val Leu Ser Gly 
                165                 170                 175     


Leu Leu Gly Met Val Ala His Met Met Tyr Ser Gln Val Phe Gln Ala 
            180                 185                 190         


Thr Val Asn Leu Gly Pro Glu Asp Trp Arg Pro His Val Trp Asn Tyr 
        195                 200                 205             


Gly Trp Ala Phe Tyr Met Ala Trp Leu Ser Phe Thr Cys Cys Met Ala 
    210                 215                 220                 


Ser Ala Val Thr Thr Phe Asn Thr Tyr Thr Arg Met Val Leu Glu Phe 
225                 230                 235                 240 


Lys Cys Lys His Ser Lys Ser Phe Lys Glu Asn Pro Asn Cys Leu Pro 
                245                 250                 255     


His His His Gln Cys Phe Pro Arg Arg Leu Ser Ser Ala Ala Pro Thr 
            260                 265                 270         


Val Gly Pro Leu Thr Ser Tyr His Gln Tyr His Asn Gln Pro Ile His 
        275                 280                 285             


Ser Val Ser Glu Gly Val Asp Phe Tyr Ser Glu Leu Arg Asn Lys Gly 
    290                 295                 300                 


Phe Gln Arg Gly Ala Ser Gln Glu Leu Lys Glu Ala Val Arg Ser Ser 
305                 310                 315                 320 


Val Glu Glu Glu Gln Cys 
                325     


<210>  6283
<211>  285
<212>  PRT
<213>  Homo Sapiens

<400>  6283

Met Ala Lys Met Glu Leu Ser Lys Ala Phe Ser Gly Gln Arg Thr Leu 
1               5                   10                  15      


Leu Ser Ala Ile Leu Ser Met Leu Ser Leu Ser Phe Ser Thr Thr Ser 
            20                  25                  30          


Leu Leu Ser Asn Tyr Trp Phe Val Gly Thr Gln Lys Val Pro Lys Pro 
        35                  40                  45              


Leu Cys Glu Lys Gly Leu Ala Ala Lys Cys Phe Asp Met Pro Val Ser 
    50                  55                  60                  


Leu Asp Gly Asp Thr Asn Thr Ser Thr Gln Glu Val Val Gln Tyr Asn 
65                  70                  75                  80  


Trp Glu Thr Gly Asp Asp Arg Phe Ser Phe Arg Ser Phe Arg Ser Gly 
                85                  90                  95      


Met Trp Leu Ser Cys Glu Glu Thr Val Glu Glu Pro Gly Glu Arg Cys 
            100                 105                 110         


Arg Ser Phe Ile Glu Leu Thr Pro Pro Ala Lys Arg Gly Glu Lys Gly 
        115                 120                 125             


Leu Leu Glu Phe Ala Thr Leu Gln Gly Pro Cys His Pro Thr Leu Arg 
    130                 135                 140                 


Phe Gly Gly Lys Arg Leu Met Glu Lys Ala Ser Leu Pro Ser Pro Pro 
145                 150                 155                 160 


Leu Gly Leu Cys Gly Lys Asn Pro Met Val Ile Pro Gly Asn Ala Asp 
                165                 170                 175     


His Leu His Arg Thr Ser Ile His Gln Leu Pro Pro Ala Thr Asn Arg 
            180                 185                 190         


Leu Ala Thr His Trp Glu Pro Cys Leu Trp Ala Gln Thr Glu Arg Leu 
        195                 200                 205             


Cys Cys Cys Phe Leu Cys Pro Val Arg Ser Pro Gly Asp Gly Gly Pro 
    210                 215                 220                 


His Asp Val Phe Thr Ser Leu Pro Ser Asp Cys Gln Leu Gly Ser Arg 
225                 230                 235                 240 


Arg Leu Glu Thr Thr Cys Leu Glu Leu Trp Leu Gly Leu Leu His Gly 
                245                 250                 255     


Leu Ala Leu Leu His Leu Leu His Gly Val Gly Cys His His Leu Gln 
            260                 265                 270         


His Val His Gln Asp Gly Ala Gly Val Gln Val Gln Ala 
        275                 280                 285 


<210>  6284
<211>  275
<212>  PRT
<213>  Homo Sapiens

<400>  6284

Met Ala Lys Met Glu Leu Ser Lys Ala Phe Ser Gly Gln Arg Thr Leu 
1               5                   10                  15      


Leu Ser Ala Ile Leu Ser Met Leu Ser Leu Ser Phe Ser Thr Thr Ser 
            20                  25                  30          


Leu Leu Ser Asn Tyr Trp Phe Val Gly Thr Gln Lys Val Pro Lys Pro 
        35                  40                  45              


Leu Cys Glu Lys Gly Leu Ala Ala Lys Cys Phe Asp Met Pro Val Ser 
    50                  55                  60                  


Leu Asp Gly Asp Thr Asn Thr Ser Thr Gln Glu Val Val Gln Tyr Asn 
65                  70                  75                  80  


Trp Glu Thr Gly Asp Asp Arg Phe Ser Phe Arg Ser Phe Arg Ser Gly 
                85                  90                  95      


Met Trp Leu Ser Cys Glu Glu Thr Val Glu Glu Pro Gly Glu Arg Cys 
            100                 105                 110         


Arg Ser Phe Ile Glu Leu Thr Pro Pro Ala Lys Arg Gly Leu Leu Gly 
        115                 120                 125             


Met Val Ala His Met Met Tyr Ser Gln Val Phe Gln Ala Thr Val Asn 
    130                 135                 140                 


Leu Gly Pro Glu Asp Trp Arg Pro His Val Trp Asn Tyr Gly Trp Ala 
145                 150                 155                 160 


Phe Tyr Met Ala Trp Leu Ser Phe Thr Cys Cys Met Ala Ser Ala Val 
                165                 170                 175     


Thr Thr Phe Asn Thr Tyr Thr Arg Met Val Leu Glu Phe Lys Cys Lys 
            180                 185                 190         


His Ser Lys Ser Phe Lys Glu Asn Pro Asn Cys Leu Pro His His His 
        195                 200                 205             


Gln Cys Phe Pro Arg Arg Leu Ser Ser Ala Ala Pro Thr Val Gly Pro 
    210                 215                 220                 


Leu Thr Ser Tyr His Gln Tyr His Asn Gln Pro Ile His Ser Val Ser 
225                 230                 235                 240 


Glu Gly Val Asp Phe Tyr Ser Glu Leu Arg Asn Lys Gly Phe Gln Arg 
                245                 250                 255     


Gly Ala Ser Gln Glu Leu Lys Glu Ala Val Arg Ser Ser Val Glu Glu 
            260                 265                 270         


Glu Gln Cys 
        275 


<210>  6285
<211>  220
<212>  PRT
<213>  Homo Sapiens

<400>  6285

Met Ser Asp Pro Ser Gln Leu Thr Gln Asn Val Cys Leu Thr Gln Glu 
1               5                   10                  15      


Met Glu Leu Ser Lys Ala Phe Ser Gly Gln Arg Thr Leu Leu Ser Ala 
            20                  25                  30          


Ile Leu Ser Met Leu Ser Leu Ser Phe Ser Thr Thr Ser Leu Leu Ser 
        35                  40                  45              


Asn Tyr Trp Phe Val Gly Thr Gln Lys Val Pro Lys Pro Leu Cys Glu 
    50                  55                  60                  


Lys Gly Leu Ala Ala Lys Cys Phe Asp Met Pro Val Ser Leu Asp Gly 
65                  70                  75                  80  


Asp Thr Asn Thr Ser Thr Gln Glu Val Val Gln Tyr Asn Trp Glu Thr 
                85                  90                  95      


Gly Asp Asp Arg Phe Ser Phe Arg Ser Phe Arg Ser Gly Met Trp Leu 
            100                 105                 110         


Ser Cys Glu Glu Thr Val Glu Glu Pro Ala Lys Ser Glu Met Glu Glu 
        115                 120                 125             


Glu Leu Lys Lys Cys Val Tyr Leu His Leu Tyr Leu Leu Leu Cys His 
    130                 135                 140                 


Leu Ala Leu Leu His Pro Gln Ser Trp Lys Gln Phe Arg Ala Leu Arg 
145                 150                 155                 160 


Ser Ser Gly Thr Ala Ala Ala Lys Gly Glu Arg Cys Arg Ser Phe Ile 
                165                 170                 175     


Glu Leu Thr Pro Pro Ala Lys Arg Glu Ile Leu Trp Leu Ser Leu Gly 
            180                 185                 190         


Thr Gln Ile Thr Tyr Ile Gly Leu Gln Phe Ile Ser Phe Leu Leu Leu 
        195                 200                 205             


Leu Thr Asp Leu Leu Leu Thr Gly Asn Pro Ala Cys 
    210                 215                 220 


<210>  6286
<211>  321
<212>  PRT
<213>  Homo Sapiens

<400>  6286

Met Ser Asp Pro Ser Gln Leu Thr Gln Asn Val Cys Leu Thr Gln Glu 
1               5                   10                  15      


Met Glu Leu Ser Lys Ala Phe Ser Gly Gln Arg Thr Leu Leu Ser Ala 
            20                  25                  30          


Ile Leu Ser Met Leu Ser Leu Ser Phe Ser Thr Thr Ser Leu Leu Ser 
        35                  40                  45              


Asn Tyr Trp Phe Val Gly Thr Gln Lys Val Pro Lys Pro Leu Cys Glu 
    50                  55                  60                  


Lys Gly Leu Ala Ala Lys Cys Phe Asp Met Pro Val Ser Leu Asp Gly 
65                  70                  75                  80  


Asp Thr Asn Thr Ser Thr Gln Glu Val Val Gln Tyr Asn Trp Glu Thr 
                85                  90                  95      


Gly Asp Asp Arg Phe Ser Phe Arg Ser Phe Arg Ser Gly Met Trp Leu 
            100                 105                 110         


Ser Cys Glu Glu Thr Val Glu Glu Pro Ala Leu Leu His Pro Gln Ser 
        115                 120                 125             


Trp Lys Gln Phe Arg Ala Leu Arg Ser Ser Gly Thr Ala Ala Ala Lys 
    130                 135                 140                 


Gly Glu Arg Cys Arg Ser Phe Ile Glu Leu Thr Pro Pro Ala Lys Arg 
145                 150                 155                 160 


Gly Glu Lys Gly Leu Leu Glu Phe Ala Thr Leu Gln Gly Pro Cys His 
                165                 170                 175     


Pro Thr Leu Arg Phe Gly Gly Lys Arg Leu Met Glu Lys Ala Ser Leu 
            180                 185                 190         


Pro Ser Pro Pro Leu Gly Leu Cys Gly Lys Asn Pro Met Val Ile Pro 
        195                 200                 205             


Gly Asn Ala Asp His Leu His Arg Thr Ser Ile His Gln Leu Pro Pro 
    210                 215                 220                 


Ala Thr Asn Arg Leu Ala Thr His Trp Glu Pro Cys Leu Trp Ala Gln 
225                 230                 235                 240 


Thr Glu Arg Leu Cys Cys Cys Phe Leu Cys Pro Val Arg Ser Pro Gly 
                245                 250                 255     


Asp Gly Gly Pro His Asp Val Phe Thr Ser Leu Pro Ser Asp Cys Gln 
            260                 265                 270         


Leu Gly Ser Arg Arg Leu Glu Thr Thr Cys Leu Glu Leu Trp Leu Gly 
        275                 280                 285             


Leu Leu His Gly Leu Ala Leu Leu His Leu Leu His Gly Val Gly Cys 
    290                 295                 300                 


His His Leu Gln His Val His Gln Asp Gly Ala Gly Val Gln Val Gln 
305                 310                 315                 320 


Ala 
    


<210>  6287
<211>  339
<212>  PRT
<213>  Homo Sapiens

<400>  6287

Met Ser Asp Pro Ser Gln Leu Thr Gln Asn Val Cys Leu Thr Gln Glu 
1               5                   10                  15      


Met Glu Leu Ser Lys Ala Phe Ser Gly Gln Arg Thr Leu Leu Ser Ala 
            20                  25                  30          


Ile Leu Ser Met Leu Ser Leu Ser Phe Ser Thr Thr Ser Leu Leu Ser 
        35                  40                  45              


Asn Tyr Trp Phe Val Gly Thr Gln Lys Val Pro Lys Pro Leu Cys Glu 
    50                  55                  60                  


Lys Gly Leu Ala Ala Lys Cys Phe Asp Met Pro Val Ser Leu Asp Gly 
65                  70                  75                  80  


Asp Thr Asn Thr Ser Thr Gln Glu Val Val Gln Tyr Asn Trp Glu Thr 
                85                  90                  95      


Gly Asp Asp Arg Phe Ser Phe Arg Ser Phe Arg Ser Gly Met Trp Leu 
            100                 105                 110         


Ser Cys Glu Glu Thr Val Glu Glu Pro Gly Glu Arg Cys Arg Ser Phe 
        115                 120                 125             


Ile Glu Leu Thr Pro Pro Ala Lys Arg Glu Ile Leu Trp Leu Ser Leu 
    130                 135                 140                 


Gly Thr Gln Ile Thr Tyr Ile Gly Leu Gln Phe Ile Ser Phe Leu Leu 
145                 150                 155                 160 


Leu Leu Thr Asp Leu Leu Leu Thr Gly Asn Pro Ala Cys Gly Leu Lys 
                165                 170                 175     


Leu Ser Ala Phe Ala Ala Val Ser Ser Val Leu Ser Gly Leu Leu Gly 
            180                 185                 190         


Met Val Ala His Met Met Tyr Ser Gln Val Phe Gln Ala Thr Val Asn 
        195                 200                 205             


Leu Gly Pro Glu Asp Trp Arg Pro His Val Trp Asn Tyr Gly Trp Ala 
    210                 215                 220                 


Phe Tyr Met Ala Trp Leu Ser Phe Thr Cys Cys Met Ala Ser Ala Val 
225                 230                 235                 240 


Thr Thr Phe Asn Thr Tyr Thr Arg Met Val Leu Glu Phe Lys Cys Lys 
                245                 250                 255     


His Ser Lys Ser Phe Lys Glu Asn Pro Asn Cys Leu Pro His His His 
            260                 265                 270         


Gln Cys Phe Pro Arg Arg Leu Ser Ser Ala Ala Pro Thr Val Gly Pro 
        275                 280                 285             


Leu Thr Ser Tyr His Gln Tyr His Asn Gln Pro Ile His Ser Val Ser 
    290                 295                 300                 


Glu Gly Val Asp Phe Tyr Ser Glu Leu Arg Asn Lys Gly Phe Gln Arg 
305                 310                 315                 320 


Gly Ala Ser Gln Glu Leu Lys Glu Ala Val Arg Ser Ser Val Glu Glu 
                325                 330                 335     


Glu Gln Cys 
            


<210>  6288
<211>  236
<212>  PRT
<213>  Homo Sapiens

<400>  6288

Met Ser Asp Pro Ser Gln Leu Thr Gln Asn Val Cys Leu Thr Gln Glu 
1               5                   10                  15      


Met Glu Leu Ser Lys Ala Phe Ser Gly Gln Arg Thr Leu Leu Ser Ala 
            20                  25                  30          


Ile Leu Ser Met Leu Ser Leu Ser Phe Ser Thr Thr Ser Leu Leu Ser 
        35                  40                  45              


Asn Tyr Trp Phe Val Gly Thr Gln Lys Val Pro Lys Pro Leu Cys Glu 
    50                  55                  60                  


Lys Gly Leu Ala Ala Lys Cys Phe Asp Met Pro Val Ser Leu Asp Gly 
65                  70                  75                  80  


Asp Thr Asn Thr Ser Thr Gln Glu Val Val Gln Tyr Asn Trp Glu Thr 
                85                  90                  95      


Gly Asp Asp Arg Phe Ser Phe Arg Ser Phe Arg Ser Gly Met Trp Leu 
            100                 105                 110         


Ser Cys Glu Glu Thr Val Glu Glu Pro Gly Glu Arg Cys Arg Ser Phe 
        115                 120                 125             


Ile Glu Leu Thr Pro Pro Ala Lys Arg Gly Glu Lys Gly Leu Leu Glu 
    130                 135                 140                 


Phe Ala Thr Leu Gln Gly Pro Cys His Pro Thr Leu Arg Phe Gly Gly 
145                 150                 155                 160 


Lys Arg Leu Met Glu Lys Ala Ser Leu Pro Ser Pro Pro Leu Gly Leu 
                165                 170                 175     


Cys Gly Lys Asn Pro Met Val Ile Pro Gly Asn Ala Asp His Leu His 
            180                 185                 190         


Arg Thr Ser Ile His Gln Leu Pro Pro Ala Thr Asn Arg Leu Ala Thr 
        195                 200                 205             


His Trp Glu Pro Cys Leu Trp Ala Gln Thr Glu Arg Leu Cys Cys Cys 
    210                 215                 220                 


Phe Leu Cys Pro Val Arg Ser Pro Gly Asp Gly Gly 
225                 230                 235     


<210>  6289
<211>  748
<212>  PRT
<213>  Homo Sapiens

<400>  6289

Met Ala Glu Glu Glu Ala Leu Arg Gly Asn Ser Asp Pro Trp Pro Asn 
1               5                   10                  15      


Ser Met Val Val Glu His Pro Glu Phe Leu Lys Ala Gly Lys Glu Pro 
            20                  25                  30          


Gly Leu Gln Ile Trp Arg Val Glu Lys Phe Asp Leu Val Pro Val Pro 
        35                  40                  45              


Thr Asn Leu Tyr Gly Asp Phe Phe Thr Gly Asp Ala Tyr Val Ile Leu 
    50                  55                  60                  


Lys Thr Val Gln Leu Arg Asn Gly Asn Leu Gln Tyr Asp Leu His Tyr 
65                  70                  75                  80  


Trp Leu Gly Asn Glu Cys Ser Gln Asp Glu Ser Gly Ala Ala Ala Ile 
                85                  90                  95      


Phe Thr Val Gln Leu Asp Asp Tyr Leu Asn Gly Arg Ala Val Gln His 
            100                 105                 110         


Arg Glu Val Gln Gly Phe Glu Ser Ala Thr Phe Leu Gly Tyr Phe Lys 
        115                 120                 125             


Ser Gly Leu Lys Tyr Lys Lys Gly Gly Val Ala Ser Gly Phe Lys His 
    130                 135                 140                 


Val Val Pro Asn Glu Val Val Val Gln Arg Leu Phe Gln Val Lys Gly 
145                 150                 155                 160 


Arg Arg Val Val Arg Ala Thr Glu Val Pro Val Ser Trp Glu Ser Phe 
                165                 170                 175     


Asn Asn Gly Asp Cys Phe Ile Leu Asp Leu Gly Asn Asn Ile His Gln 
            180                 185                 190         


Trp Cys Gly Ser Asn Ser Asn Arg Tyr Glu Arg Leu Lys Ala Thr Gln 
        195                 200                 205             


Val Ser Lys Gly Ile Arg Asp Asn Glu Arg Ser Gly Arg Ala Arg Val 
    210                 215                 220                 


His Val Ser Glu Glu Gly Thr Glu Pro Glu Ala Met Leu Gln Val Leu 
225                 230                 235                 240 


Gly Pro Lys Pro Ala Leu Pro Ala Gly Thr Glu Asp Thr Ala Lys Glu 
                245                 250                 255     


Asp Ala Ala Asn Arg Lys Leu Ala Lys Leu Tyr Lys Val Ser Asn Gly 
            260                 265                 270         


Ala Gly Thr Met Ser Val Ser Leu Val Ala Asp Glu Asn Pro Phe Ala 
        275                 280                 285             


Gln Gly Ala Leu Lys Ser Glu Asp Cys Phe Ile Leu Asp His Gly Lys 
    290                 295                 300                 


Asp Gly Lys Ile Phe Val Trp Lys Gly Lys Gln Ala Asn Thr Glu Glu 
305                 310                 315                 320 


Arg Lys Ala Ala Leu Lys Thr Ala Ser Asp Phe Ile Thr Lys Met Asp 
                325                 330                 335     


Tyr Pro Lys Gln Thr Gln Val Ser Val Leu Pro Glu Gly Gly Glu Thr 
            340                 345                 350         


Pro Leu Phe Lys Gln Phe Phe Lys Asn Trp Arg Asp Pro Asp Gln Thr 
        355                 360                 365             


Asp Gly Leu Gly Leu Ser Tyr Leu Ser Ser His Ile Ala Asn Val Glu 
    370                 375                 380                 


Arg Val Pro Phe Asp Ala Ala Thr Leu His Thr Ser Thr Ala Met Ala 
385                 390                 395                 400 


Ala Gln His Gly Met Asp Asp Asp Gly Thr Gly Gln Lys Gln Ile Trp 
                405                 410                 415     


Arg Ile Glu Gly Ser Asn Lys Val Pro Val Asp Pro Ala Thr Tyr Gly 
            420                 425                 430         


Gln Phe Tyr Gly Gly Asp Ser Tyr Ile Ile Leu Tyr Asn Tyr Arg His 
        435                 440                 445             


Gly Gly Arg Gln Gly Gln Ile Ile Tyr Asn Trp Gln Gly Ala Gln Ser 
    450                 455                 460                 


Thr Gln Asp Glu Val Ala Ala Ser Ala Ile Leu Thr Ala Gln Leu Asp 
465                 470                 475                 480 


Glu Glu Leu Gly Gly Thr Pro Val Gln Ser Arg Val Val Gln Gly Lys 
                485                 490                 495     


Glu Pro Ala His Leu Met Ser Leu Phe Gly Gly Lys Pro Met Ile Ile 
            500                 505                 510         


Tyr Lys Gly Gly Thr Ser Arg Glu Gly Gly Gln Thr Ala Pro Ala Ser 
        515                 520                 525             


Thr Arg Leu Phe Gln Val Arg Ala Asn Ser Ala Gly Ala Thr Arg Ala 
    530                 535                 540                 


Val Glu Val Leu Pro Lys Ala Gly Ala Leu Asn Ser Asn Asp Ala Phe 
545                 550                 555                 560 


Val Leu Lys Thr Pro Ser Ala Ala Tyr Leu Trp Val Gly Thr Gly Ala 
                565                 570                 575     


Ser Glu Ala Glu Lys Thr Gly Ala Gln Glu Leu Leu Arg Val Leu Arg 
            580                 585                 590         


Ala Gln Pro Val Gln Val Ala Glu Gly Ser Glu Pro Asp Gly Phe Trp 
        595                 600                 605             


Glu Ala Leu Gly Gly Lys Ala Ala Tyr Arg Thr Ser Pro Arg Leu Lys 
    610                 615                 620                 


Asp Lys Lys Met Asp Ala His Pro Pro Arg Leu Phe Ala Cys Ser Asn 
625                 630                 635                 640 


Lys Ile Gly Arg Phe Val Ile Glu Glu Val Pro Gly Glu Leu Met Gln 
                645                 650                 655     


Glu Asp Leu Ala Thr Asp Asp Val Met Leu Leu Asp Thr Trp Asp Gln 
            660                 665                 670         


Val Phe Val Trp Val Gly Lys Asp Ser Gln Glu Glu Glu Lys Thr Glu 
        675                 680                 685             


Ala Leu Thr Ser Ala Lys Arg Tyr Ile Glu Thr Asp Pro Ala Asn Arg 
    690                 695                 700                 


Asp Arg Arg Thr Pro Ile Thr Val Val Lys Gln Gly Phe Glu Pro Pro 
705                 710                 715                 720 


Ser Phe Val Gly Trp Phe Leu Gly Trp Asp Asp Asp Tyr Trp Ser Val 
                725                 730                 735     


Asp Pro Leu Asp Arg Ala Met Ala Glu Leu Ala Ala 
            740                 745             


<210>  6290
<211>  782
<212>  PRT
<213>  Homo Sapiens

<400>  6290

Met Ala Pro His Arg Pro Ala Pro Ala Leu Leu Cys Ala Leu Ser Leu 
1               5                   10                  15      


Ala Leu Cys Ala Leu Ser Leu Pro Val Arg Ala Ala Thr Ala Ser Arg 
            20                  25                  30          


Gly Ala Ser Gln Ala Gly Ala Pro Gln Gly Arg Val Pro Glu Ala Arg 
        35                  40                  45              


Pro Asn Ser Met Val Val Glu His Pro Glu Phe Leu Lys Ala Gly Lys 
    50                  55                  60                  


Glu Pro Gly Leu Gln Ile Trp Arg Val Glu Lys Phe Asp Leu Val Pro 
65                  70                  75                  80  


Val Pro Thr Asn Leu Tyr Gly Asp Phe Phe Thr Gly Asp Ala Tyr Val 
                85                  90                  95      


Ile Leu Lys Thr Val Gln Leu Arg Asn Gly Asn Leu Gln Tyr Asp Leu 
            100                 105                 110         


His Tyr Trp Leu Gly Asn Glu Cys Ser Gln Asp Glu Ser Gly Ala Ala 
        115                 120                 125             


Ala Ile Phe Thr Val Gln Leu Asp Asp Tyr Leu Asn Gly Arg Ala Val 
    130                 135                 140                 


Gln His Arg Glu Val Gln Gly Phe Glu Ser Ala Thr Phe Leu Gly Tyr 
145                 150                 155                 160 


Phe Lys Ser Gly Leu Lys Tyr Lys Lys Gly Gly Val Ala Ser Gly Phe 
                165                 170                 175     


Lys His Val Val Pro Asn Glu Val Val Val Gln Arg Leu Phe Gln Val 
            180                 185                 190         


Lys Gly Arg Arg Val Val Arg Ala Thr Glu Val Pro Val Ser Trp Glu 
        195                 200                 205             


Ser Phe Asn Asn Gly Asp Cys Phe Ile Leu Asp Leu Gly Asn Asn Ile 
    210                 215                 220                 


His Gln Trp Cys Gly Ser Asn Ser Asn Arg Tyr Glu Arg Leu Lys Ala 
225                 230                 235                 240 


Thr Gln Val Ser Lys Gly Ile Arg Asp Asn Glu Arg Ser Gly Arg Ala 
                245                 250                 255     


Arg Val His Val Ser Glu Glu Gly Thr Glu Pro Glu Ala Met Leu Gln 
            260                 265                 270         


Val Leu Gly Pro Lys Pro Ala Leu Pro Ala Gly Thr Glu Asp Thr Ala 
        275                 280                 285             


Lys Glu Asp Ala Ala Asn Arg Lys Leu Ala Lys Leu Tyr Lys Val Ser 
    290                 295                 300                 


Asn Gly Ala Gly Thr Met Ser Val Ser Leu Val Ala Asp Glu Asn Pro 
305                 310                 315                 320 


Phe Ala Gln Gly Ala Leu Lys Ser Glu Asp Cys Phe Ile Leu Asp His 
                325                 330                 335     


Gly Lys Asp Gly Lys Ile Phe Val Trp Lys Gly Lys Gln Ala Asn Thr 
            340                 345                 350         


Glu Glu Arg Lys Ala Ala Leu Lys Thr Ala Ser Asp Phe Ile Thr Lys 
        355                 360                 365             


Met Asp Tyr Pro Lys Gln Thr Gln Val Ser Val Leu Pro Glu Gly Gly 
    370                 375                 380                 


Glu Thr Pro Leu Phe Lys Gln Phe Phe Lys Asn Trp Arg Asp Pro Asp 
385                 390                 395                 400 


Gln Thr Asp Gly Leu Gly Leu Ser Tyr Leu Ser Ser His Ile Ala Asn 
                405                 410                 415     


Val Glu Arg Val Pro Phe Asp Ala Ala Thr Leu His Thr Ser Thr Ala 
            420                 425                 430         


Met Ala Ala Gln His Gly Met Asp Asp Asp Gly Thr Gly Gln Lys Gln 
        435                 440                 445             


Ile Trp Arg Ile Glu Gly Ser Asn Lys Val Pro Val Asp Pro Ala Thr 
    450                 455                 460                 


Tyr Gly Gln Phe Tyr Gly Gly Asp Ser Tyr Ile Ile Leu Tyr Asn Tyr 
465                 470                 475                 480 


Arg His Gly Gly Arg Gln Gly Gln Ile Ile Tyr Asn Trp Gln Gly Ala 
                485                 490                 495     


Gln Ser Thr Gln Asp Glu Val Ala Ala Ser Ala Ile Leu Thr Ala Gln 
            500                 505                 510         


Leu Asp Glu Glu Leu Gly Gly Thr Pro Val Gln Ser Arg Val Val Gln 
        515                 520                 525             


Gly Lys Glu Pro Ala His Leu Met Ser Leu Phe Gly Gly Lys Pro Met 
    530                 535                 540                 


Ile Ile Tyr Lys Gly Gly Thr Ser Arg Glu Gly Gly Gln Thr Ala Pro 
545                 550                 555                 560 


Ala Ser Thr Arg Leu Phe Gln Val Arg Ala Asn Ser Ala Gly Ala Thr 
                565                 570                 575     


Arg Ala Val Glu Val Leu Pro Lys Ala Gly Ala Leu Asn Ser Asn Asp 
            580                 585                 590         


Ala Phe Val Leu Lys Thr Pro Ser Ala Ala Tyr Leu Trp Val Gly Thr 
        595                 600                 605             


Gly Ala Ser Glu Ala Glu Lys Thr Gly Ala Gln Glu Leu Leu Arg Val 
    610                 615                 620                 


Leu Arg Ala Gln Pro Val Gln Val Ala Glu Gly Ser Glu Pro Asp Gly 
625                 630                 635                 640 


Phe Trp Glu Ala Leu Gly Gly Lys Ala Ala Tyr Arg Thr Ser Pro Arg 
                645                 650                 655     


Leu Lys Asp Lys Lys Met Asp Ala His Pro Pro Arg Leu Phe Ala Cys 
            660                 665                 670         


Ser Asn Lys Ile Gly Arg Phe Val Ile Glu Glu Val Pro Gly Glu Leu 
        675                 680                 685             


Met Gln Glu Asp Leu Ala Thr Asp Asp Val Met Leu Leu Asp Thr Trp 
    690                 695                 700                 


Asp Gln Val Phe Val Trp Val Gly Lys Asp Ser Gln Glu Glu Glu Lys 
705                 710                 715                 720 


Thr Glu Ala Leu Thr Ser Ala Lys Arg Tyr Ile Glu Thr Asp Pro Ala 
                725                 730                 735     


Asn Arg Asp Arg Arg Thr Pro Ile Thr Val Val Lys Gln Gly Phe Glu 
            740                 745                 750         


Pro Pro Ser Phe Val Gly Trp Phe Leu Gly Trp Asp Asp Asp Tyr Trp 
        755                 760                 765             


Ser Val Asp Pro Leu Asp Arg Ala Met Ala Glu Leu Ala Ala 
    770                 775                 780         


<210>  6291
<211>  232
<212>  PRT
<213>  Homo Sapiens

<400>  6291

Met Glu Lys Leu Phe Cys Cys Phe Pro Asn Ser Met Val Val Glu His 
1               5                   10                  15      


Pro Glu Phe Leu Lys Ala Gly Lys Glu Pro Gly Leu Gln Ile Trp Arg 
            20                  25                  30          


Val Glu Lys Phe Asp Leu Val Pro Val Pro Thr Asn Leu Tyr Gly Asp 
        35                  40                  45              


Phe Phe Thr Gly Asp Ala Tyr Val Ile Leu Lys Thr Val Gln Leu Arg 
    50                  55                  60                  


Asn Gly Asn Leu Gln Tyr Asp Leu His Tyr Trp Leu Gly Asn Glu Cys 
65                  70                  75                  80  


Ser Gln Asp Glu Ser Gly Ala Ala Ala Ile Phe Thr Val Gln Leu Asp 
                85                  90                  95      


Asp Tyr Leu Asn Gly Arg Ala Val Gln His Arg Glu Val Gln Gly Phe 
            100                 105                 110         


Glu Ser Ala Thr Phe Leu Gly Tyr Phe Lys Ser Gly Leu Lys Tyr Lys 
        115                 120                 125             


Lys Gly Gly Val Ala Ser Gly Phe Lys His Val Val Pro Asn Glu Val 
    130                 135                 140                 


Val Val Gln Arg Leu Phe Gln Val Lys Gly Arg Arg Val Val Arg Ala 
145                 150                 155                 160 


Thr Glu Val Pro Val Ser Trp Glu Ser Phe Asn Asn Gly Asp Cys Phe 
                165                 170                 175     


Ile Leu Asp Leu Gly Asn Asn Ile His Gln Trp Cys Gly Ser Asn Ser 
            180                 185                 190         


Asn Arg Tyr Glu Arg Leu Lys Ala Thr Gln Val Ser Lys Gly Ile Arg 
        195                 200                 205             


Asp Asn Glu Arg Ser Gly Arg Ala Arg Val His Val Ser Glu Glu Gly 
    210                 215                 220                 


Thr Glu Pro Glu Ala Met Leu Gln 
225                 230         


<210>  6292
<211>  742
<212>  PRT
<213>  Homo Sapiens

<400>  6292

Met Glu Lys Leu Phe Cys Cys Phe Pro Asn Ser Met Val Val Glu His 
1               5                   10                  15      


Pro Glu Phe Leu Lys Ala Gly Lys Glu Pro Gly Leu Gln Ile Trp Arg 
            20                  25                  30          


Val Glu Lys Phe Asp Leu Val Pro Val Pro Thr Asn Leu Tyr Gly Asp 
        35                  40                  45              


Phe Phe Thr Gly Asp Ala Tyr Val Ile Leu Lys Thr Val Gln Leu Arg 
    50                  55                  60                  


Asn Gly Asn Leu Gln Tyr Asp Leu His Tyr Trp Leu Gly Asn Glu Cys 
65                  70                  75                  80  


Ser Gln Asp Glu Ser Gly Ala Ala Ala Ile Phe Thr Val Gln Leu Asp 
                85                  90                  95      


Asp Tyr Leu Asn Gly Arg Ala Val Gln His Arg Glu Val Gln Gly Phe 
            100                 105                 110         


Glu Ser Ala Thr Phe Leu Gly Tyr Phe Lys Ser Gly Leu Lys Tyr Lys 
        115                 120                 125             


Lys Gly Gly Val Ala Ser Gly Phe Lys His Val Val Pro Asn Glu Val 
    130                 135                 140                 


Val Val Gln Arg Leu Phe Gln Val Lys Gly Arg Arg Val Val Arg Ala 
145                 150                 155                 160 


Thr Glu Val Pro Val Ser Trp Glu Ser Phe Asn Asn Gly Asp Cys Phe 
                165                 170                 175     


Ile Leu Asp Leu Gly Asn Asn Ile His Gln Trp Cys Gly Ser Asn Ser 
            180                 185                 190         


Asn Arg Tyr Glu Arg Leu Lys Ala Thr Gln Val Ser Lys Gly Ile Arg 
        195                 200                 205             


Asp Asn Glu Arg Ser Gly Arg Ala Arg Val His Val Ser Glu Glu Gly 
    210                 215                 220                 


Thr Glu Pro Glu Ala Met Leu Gln Val Leu Gly Pro Lys Pro Ala Leu 
225                 230                 235                 240 


Pro Ala Gly Thr Glu Asp Thr Ala Lys Glu Asp Ala Ala Asn Arg Lys 
                245                 250                 255     


Leu Ala Lys Leu Tyr Lys Val Ser Asn Gly Ala Gly Thr Met Ser Val 
            260                 265                 270         


Ser Leu Val Ala Asp Glu Asn Pro Phe Ala Gln Gly Ala Leu Lys Ser 
        275                 280                 285             


Glu Asp Cys Phe Ile Leu Asp His Gly Lys Asp Gly Lys Ile Phe Val 
    290                 295                 300                 


Trp Lys Gly Lys Gln Ala Asn Thr Glu Glu Arg Lys Ala Ala Leu Lys 
305                 310                 315                 320 


Thr Ala Ser Asp Phe Ile Thr Lys Met Asp Tyr Pro Lys Gln Thr Gln 
                325                 330                 335     


Val Ser Val Leu Pro Glu Gly Gly Glu Thr Pro Leu Phe Lys Gln Phe 
            340                 345                 350         


Phe Lys Asn Trp Arg Asp Pro Asp Gln Thr Asp Gly Leu Gly Leu Ser 
        355                 360                 365             


Tyr Leu Ser Ser His Ile Ala Asn Val Glu Arg Val Pro Phe Asp Ala 
    370                 375                 380                 


Ala Thr Leu His Thr Ser Thr Ala Met Ala Ala Gln His Gly Met Asp 
385                 390                 395                 400 


Asp Asp Gly Thr Gly Gln Lys Gln Ile Trp Arg Ile Glu Gly Ser Asn 
                405                 410                 415     


Lys Val Pro Val Asp Pro Ala Thr Tyr Gly Gln Phe Tyr Gly Gly Asp 
            420                 425                 430         


Ser Tyr Ile Ile Leu Tyr Asn Tyr Arg His Gly Gly Arg Gln Gly Gln 
        435                 440                 445             


Ile Ile Tyr Asn Trp Gln Gly Ala Gln Ser Thr Gln Asp Glu Val Ala 
    450                 455                 460                 


Ala Ser Ala Ile Leu Thr Ala Gln Leu Asp Glu Glu Leu Gly Gly Thr 
465                 470                 475                 480 


Pro Val Gln Ser Arg Val Val Gln Gly Lys Glu Pro Ala His Leu Met 
                485                 490                 495     


Ser Leu Phe Gly Gly Lys Pro Met Ile Ile Tyr Lys Gly Gly Thr Ser 
            500                 505                 510         


Arg Glu Gly Gly Gln Thr Ala Pro Ala Ser Thr Arg Leu Phe Gln Val 
        515                 520                 525             


Arg Ala Asn Ser Ala Gly Ala Thr Arg Ala Val Glu Val Leu Pro Lys 
    530                 535                 540                 


Ala Gly Ala Leu Asn Ser Asn Asp Ala Phe Val Leu Lys Thr Pro Ser 
545                 550                 555                 560 


Ala Ala Tyr Leu Trp Val Gly Thr Gly Ala Ser Glu Ala Glu Lys Thr 
                565                 570                 575     


Gly Ala Gln Glu Leu Leu Arg Val Leu Arg Ala Gln Pro Val Gln Val 
            580                 585                 590         


Ala Glu Gly Ser Glu Pro Asp Gly Phe Trp Glu Ala Leu Gly Gly Lys 
        595                 600                 605             


Ala Ala Tyr Arg Thr Ser Pro Arg Leu Lys Asp Lys Lys Met Asp Ala 
    610                 615                 620                 


His Pro Pro Arg Leu Phe Ala Cys Ser Asn Lys Ile Gly Arg Phe Val 
625                 630                 635                 640 


Ile Glu Glu Val Pro Gly Glu Leu Met Gln Glu Asp Leu Ala Thr Asp 
                645                 650                 655     


Asp Val Met Leu Leu Asp Thr Trp Asp Gln Val Phe Val Trp Val Gly 
            660                 665                 670         


Lys Asp Ser Gln Glu Glu Glu Lys Thr Glu Ala Leu Thr Ser Ala Lys 
        675                 680                 685             


Arg Tyr Ile Glu Thr Asp Pro Ala Asn Arg Asp Arg Arg Thr Pro Ile 
    690                 695                 700                 


Thr Val Val Lys Gln Gly Phe Glu Pro Pro Ser Phe Val Gly Trp Phe 
705                 710                 715                 720 


Leu Gly Trp Asp Asp Asp Tyr Trp Ser Val Asp Pro Leu Asp Arg Ala 
                725                 730                 735     


Met Ala Glu Leu Ala Ala 
            740         


<210>  6293
<211>  767
<212>  PRT
<213>  Homo Sapiens

<400>  6293

Met Asn Thr Gly Leu Thr Arg Leu Leu Trp Pro Ser Trp Leu Pro Asp 
1               5                   10                  15      


Gly Asp Met Ser His Pro Gln Pro Glu Leu Phe Leu Phe Pro Lys Ala 
            20                  25                  30          


Gln Pro Asn Ser Met Val Val Glu His Pro Glu Phe Leu Lys Ala Gly 
        35                  40                  45              


Lys Glu Pro Gly Leu Gln Ile Trp Arg Val Glu Lys Phe Asp Leu Val 
    50                  55                  60                  


Pro Val Pro Thr Asn Leu Tyr Gly Asp Phe Phe Thr Gly Asp Ala Tyr 
65                  70                  75                  80  


Val Ile Leu Lys Thr Val Gln Leu Arg Asn Gly Asn Leu Gln Tyr Asp 
                85                  90                  95      


Leu His Tyr Trp Leu Gly Asn Glu Cys Ser Gln Asp Glu Ser Gly Ala 
            100                 105                 110         


Ala Ala Ile Phe Thr Val Gln Leu Asp Asp Tyr Leu Asn Gly Arg Ala 
        115                 120                 125             


Val Gln His Arg Glu Val Gln Gly Phe Glu Ser Ala Thr Phe Leu Gly 
    130                 135                 140                 


Tyr Phe Lys Ser Gly Leu Lys Tyr Lys Lys Gly Gly Val Ala Ser Gly 
145                 150                 155                 160 


Phe Lys His Val Val Pro Asn Glu Val Val Val Gln Arg Leu Phe Gln 
                165                 170                 175     


Val Lys Gly Arg Arg Val Val Arg Ala Thr Glu Val Pro Val Ser Trp 
            180                 185                 190         


Glu Ser Phe Asn Asn Gly Asp Cys Phe Ile Leu Asp Leu Gly Asn Asn 
        195                 200                 205             


Ile His Gln Trp Cys Gly Ser Asn Ser Asn Arg Tyr Glu Arg Leu Lys 
    210                 215                 220                 


Ala Thr Gln Val Ser Lys Gly Ile Arg Asp Asn Glu Arg Ser Gly Arg 
225                 230                 235                 240 


Ala Arg Val His Val Ser Glu Glu Gly Thr Glu Pro Glu Ala Met Leu 
                245                 250                 255     


Gln Val Leu Gly Pro Lys Pro Ala Leu Pro Ala Gly Thr Glu Asp Thr 
            260                 265                 270         


Ala Lys Glu Asp Ala Ala Asn Arg Lys Leu Ala Lys Leu Tyr Lys Val 
        275                 280                 285             


Ser Asn Gly Ala Gly Thr Met Ser Val Ser Leu Val Ala Asp Glu Asn 
    290                 295                 300                 


Pro Phe Ala Gln Gly Ala Leu Lys Ser Glu Asp Cys Phe Ile Leu Asp 
305                 310                 315                 320 


His Gly Lys Asp Gly Lys Ile Phe Val Trp Lys Gly Lys Gln Ala Asn 
                325                 330                 335     


Thr Glu Glu Arg Lys Ala Ala Leu Lys Thr Ala Ser Asp Phe Ile Thr 
            340                 345                 350         


Lys Met Asp Tyr Pro Lys Gln Thr Gln Val Ser Val Leu Pro Glu Gly 
        355                 360                 365             


Gly Glu Thr Pro Leu Phe Lys Gln Phe Phe Lys Asn Trp Arg Asp Pro 
    370                 375                 380                 


Asp Gln Thr Asp Gly Leu Gly Leu Ser Tyr Leu Ser Ser His Ile Ala 
385                 390                 395                 400 


Asn Val Glu Arg Val Pro Phe Asp Ala Ala Thr Leu His Thr Ser Thr 
                405                 410                 415     


Ala Met Ala Ala Gln His Gly Met Asp Asp Asp Gly Thr Gly Gln Lys 
            420                 425                 430         


Gln Ile Trp Arg Ile Glu Gly Ser Asn Lys Val Pro Val Asp Pro Ala 
        435                 440                 445             


Thr Tyr Gly Gln Phe Tyr Gly Gly Asp Ser Tyr Ile Ile Leu Tyr Asn 
    450                 455                 460                 


Tyr Arg His Gly Gly Arg Gln Gly Gln Ile Ile Tyr Asn Trp Gln Gly 
465                 470                 475                 480 


Ala Gln Ser Thr Gln Asp Glu Val Ala Ala Ser Ala Ile Leu Thr Ala 
                485                 490                 495     


Gln Leu Asp Glu Glu Leu Gly Gly Thr Pro Val Gln Ser Arg Val Val 
            500                 505                 510         


Gln Gly Lys Glu Pro Ala His Leu Met Ser Leu Phe Gly Gly Lys Pro 
        515                 520                 525             


Met Ile Ile Tyr Lys Gly Gly Thr Ser Arg Glu Gly Gly Gln Thr Ala 
    530                 535                 540                 


Pro Ala Ser Thr Arg Leu Phe Gln Val Arg Ala Asn Ser Ala Gly Ala 
545                 550                 555                 560 


Thr Arg Ala Val Glu Val Leu Pro Lys Ala Gly Ala Leu Asn Ser Asn 
                565                 570                 575     


Asp Ala Phe Val Leu Lys Thr Pro Ser Ala Ala Tyr Leu Trp Val Gly 
            580                 585                 590         


Thr Gly Ala Ser Glu Ala Glu Lys Thr Gly Ala Gln Glu Leu Leu Arg 
        595                 600                 605             


Val Leu Arg Ala Gln Pro Val Gln Val Ala Glu Gly Ser Glu Pro Asp 
    610                 615                 620                 


Gly Phe Trp Glu Ala Leu Gly Gly Lys Ala Ala Tyr Arg Thr Ser Pro 
625                 630                 635                 640 


Arg Leu Lys Asp Lys Lys Met Asp Ala His Pro Pro Arg Leu Phe Ala 
                645                 650                 655     


Cys Ser Asn Lys Ile Gly Arg Phe Val Ile Glu Glu Val Pro Gly Glu 
            660                 665                 670         


Leu Met Gln Glu Asp Leu Ala Thr Asp Asp Val Met Leu Leu Asp Thr 
        675                 680                 685             


Trp Asp Gln Val Phe Val Trp Val Gly Lys Asp Ser Gln Glu Glu Glu 
    690                 695                 700                 


Lys Thr Glu Ala Leu Thr Ser Ala Lys Arg Tyr Ile Glu Thr Asp Pro 
705                 710                 715                 720 


Ala Asn Arg Asp Arg Arg Thr Pro Ile Thr Val Val Lys Gln Gly Phe 
                725                 730                 735     


Glu Pro Pro Ser Phe Val Gly Trp Phe Leu Gly Trp Asp Asp Asp Tyr 
            740                 745                 750         


Trp Ser Val Asp Pro Leu Asp Arg Ala Met Ala Glu Leu Ala Ala 
        755                 760                 765         


<210>  6294
<211>  739
<212>  PRT
<213>  Homo Sapiens

<400>  6294

Met Pro Leu Cys Thr Pro Asn Ser Met Val Val Glu His Pro Glu Phe 
1               5                   10                  15      


Leu Lys Ala Gly Lys Glu Pro Gly Leu Gln Ile Trp Arg Val Glu Lys 
            20                  25                  30          


Phe Asp Leu Val Pro Val Pro Thr Asn Leu Tyr Gly Asp Phe Phe Thr 
        35                  40                  45              


Gly Asp Ala Tyr Val Ile Leu Lys Thr Val Gln Leu Arg Asn Gly Asn 
    50                  55                  60                  


Leu Gln Tyr Asp Leu His Tyr Trp Leu Gly Asn Glu Cys Ser Gln Asp 
65                  70                  75                  80  


Glu Ser Gly Ala Ala Ala Ile Phe Thr Val Gln Leu Asp Asp Tyr Leu 
                85                  90                  95      


Asn Gly Arg Ala Val Gln His Arg Glu Val Gln Gly Phe Glu Ser Ala 
            100                 105                 110         


Thr Phe Leu Gly Tyr Phe Lys Ser Gly Leu Lys Tyr Lys Lys Gly Gly 
        115                 120                 125             


Val Ala Ser Gly Phe Lys His Val Val Pro Asn Glu Val Val Val Gln 
    130                 135                 140                 


Arg Leu Phe Gln Val Lys Gly Arg Arg Val Val Arg Ala Thr Glu Val 
145                 150                 155                 160 


Pro Val Ser Trp Glu Ser Phe Asn Asn Gly Asp Cys Phe Ile Leu Asp 
                165                 170                 175     


Leu Gly Asn Asn Ile His Gln Trp Cys Gly Ser Asn Ser Asn Arg Tyr 
            180                 185                 190         


Glu Arg Leu Lys Ala Thr Gln Val Ser Lys Gly Ile Arg Asp Asn Glu 
        195                 200                 205             


Arg Ser Gly Arg Ala Arg Val His Val Ser Glu Glu Gly Thr Glu Pro 
    210                 215                 220                 


Glu Ala Met Leu Gln Val Leu Gly Pro Lys Pro Ala Leu Pro Ala Gly 
225                 230                 235                 240 


Thr Glu Asp Thr Ala Lys Glu Asp Ala Ala Asn Arg Lys Leu Ala Lys 
                245                 250                 255     


Leu Tyr Lys Val Ser Asn Gly Ala Gly Thr Met Ser Val Ser Leu Val 
            260                 265                 270         


Ala Asp Glu Asn Pro Phe Ala Gln Gly Ala Leu Lys Ser Glu Asp Cys 
        275                 280                 285             


Phe Ile Leu Asp His Gly Lys Asp Gly Lys Ile Phe Val Trp Lys Gly 
    290                 295                 300                 


Lys Gln Ala Asn Thr Glu Glu Arg Lys Ala Ala Leu Lys Thr Ala Ser 
305                 310                 315                 320 


Asp Phe Ile Thr Lys Met Asp Tyr Pro Lys Gln Thr Gln Val Ser Val 
                325                 330                 335     


Leu Pro Glu Gly Gly Glu Thr Pro Leu Phe Lys Gln Phe Phe Lys Asn 
            340                 345                 350         


Trp Arg Asp Pro Asp Gln Thr Asp Gly Leu Gly Leu Ser Tyr Leu Ser 
        355                 360                 365             


Ser His Ile Ala Asn Val Glu Arg Val Pro Phe Asp Ala Ala Thr Leu 
    370                 375                 380                 


His Thr Ser Thr Ala Met Ala Ala Gln His Gly Met Asp Asp Asp Gly 
385                 390                 395                 400 


Thr Gly Gln Lys Gln Ile Trp Arg Ile Glu Gly Ser Asn Lys Val Pro 
                405                 410                 415     


Val Asp Pro Ala Thr Tyr Gly Gln Phe Tyr Gly Gly Asp Ser Tyr Ile 
            420                 425                 430         


Ile Leu Tyr Asn Tyr Arg His Gly Gly Arg Gln Gly Gln Ile Ile Tyr 
        435                 440                 445             


Asn Trp Gln Gly Ala Gln Ser Thr Gln Asp Glu Val Ala Ala Ser Ala 
    450                 455                 460                 


Ile Leu Thr Ala Gln Leu Asp Glu Glu Leu Gly Gly Thr Pro Val Gln 
465                 470                 475                 480 


Ser Arg Val Val Gln Gly Lys Glu Pro Ala His Leu Met Ser Leu Phe 
                485                 490                 495     


Gly Gly Lys Pro Met Ile Ile Tyr Lys Gly Gly Thr Ser Arg Glu Gly 
            500                 505                 510         


Gly Gln Thr Ala Pro Ala Ser Thr Arg Leu Phe Gln Val Arg Ala Asn 
        515                 520                 525             


Ser Ala Gly Ala Thr Arg Ala Val Glu Val Leu Pro Lys Ala Gly Ala 
    530                 535                 540                 


Leu Asn Ser Asn Asp Ala Phe Val Leu Lys Thr Pro Ser Ala Ala Tyr 
545                 550                 555                 560 


Leu Trp Val Gly Thr Gly Ala Ser Glu Ala Glu Lys Thr Gly Ala Gln 
                565                 570                 575     


Glu Leu Leu Arg Val Leu Arg Ala Gln Pro Val Gln Val Ala Glu Gly 
            580                 585                 590         


Ser Glu Pro Asp Gly Phe Trp Glu Ala Leu Gly Gly Lys Ala Ala Tyr 
        595                 600                 605             


Arg Thr Ser Pro Arg Leu Lys Asp Lys Lys Met Asp Ala His Pro Pro 
    610                 615                 620                 


Arg Leu Phe Ala Cys Ser Asn Lys Ile Gly Arg Phe Val Ile Glu Glu 
625                 630                 635                 640 


Val Pro Gly Glu Leu Met Gln Glu Asp Leu Ala Thr Asp Asp Val Met 
                645                 650                 655     


Leu Leu Asp Thr Trp Asp Gln Val Phe Val Trp Val Gly Lys Asp Ser 
            660                 665                 670         


Gln Glu Glu Glu Lys Thr Glu Ala Leu Thr Ser Ala Lys Arg Tyr Ile 
        675                 680                 685             


Glu Thr Asp Pro Ala Asn Arg Asp Arg Arg Thr Pro Ile Thr Val Val 
    690                 695                 700                 


Lys Gln Gly Phe Glu Pro Pro Ser Phe Val Gly Trp Phe Leu Gly Trp 
705                 710                 715                 720 


Asp Asp Asp Tyr Trp Ser Val Asp Pro Leu Asp Arg Ala Met Ala Glu 
                725                 730                 735     


Leu Ala Ala 
            


<210>  6295
<211>  731
<212>  PRT
<213>  Homo Sapiens

<400>  6295

Met Val Val Glu His Pro Glu Phe Leu Lys Ala Gly Lys Glu Pro Gly 
1               5                   10                  15      


Leu Gln Ile Trp Arg Val Glu Lys Phe Asp Leu Val Pro Val Pro Thr 
            20                  25                  30          


Asn Leu Tyr Gly Asp Phe Phe Thr Gly Asp Ala Tyr Val Ile Leu Lys 
        35                  40                  45              


Thr Val Gln Leu Arg Asn Gly Asn Leu Gln Tyr Asp Leu His Tyr Trp 
    50                  55                  60                  


Leu Gly Asn Glu Cys Ser Gln Asp Glu Ser Gly Ala Ala Ala Ile Phe 
65                  70                  75                  80  


Thr Val Gln Leu Asp Asp Tyr Leu Asn Gly Arg Ala Val Gln His Arg 
                85                  90                  95      


Glu Val Gln Gly Phe Glu Ser Ala Thr Phe Leu Gly Tyr Phe Lys Ser 
            100                 105                 110         


Gly Leu Lys Tyr Lys Lys Gly Gly Val Ala Ser Gly Phe Lys His Val 
        115                 120                 125             


Val Pro Asn Glu Val Val Val Gln Arg Leu Phe Gln Val Lys Gly Arg 
    130                 135                 140                 


Arg Val Val Arg Ala Thr Glu Val Pro Val Ser Trp Glu Ser Phe Asn 
145                 150                 155                 160 


Asn Gly Asp Cys Phe Ile Leu Asp Leu Gly Asn Asn Ile His Gln Trp 
                165                 170                 175     


Cys Gly Ser Asn Ser Asn Arg Tyr Glu Arg Leu Lys Ala Thr Gln Val 
            180                 185                 190         


Ser Lys Gly Ile Arg Asp Asn Glu Arg Ser Gly Arg Ala Arg Val His 
        195                 200                 205             


Val Ser Glu Glu Gly Thr Glu Pro Glu Ala Met Leu Gln Val Leu Gly 
    210                 215                 220                 


Pro Lys Pro Ala Leu Pro Ala Gly Thr Glu Asp Thr Ala Lys Glu Asp 
225                 230                 235                 240 


Ala Ala Asn Arg Lys Leu Ala Lys Leu Tyr Lys Val Ser Asn Gly Ala 
                245                 250                 255     


Gly Thr Met Ser Val Ser Leu Val Ala Asp Glu Asn Pro Phe Ala Gln 
            260                 265                 270         


Gly Ala Leu Lys Ser Glu Asp Cys Phe Ile Leu Asp His Gly Lys Asp 
        275                 280                 285             


Gly Lys Ile Phe Val Trp Lys Gly Lys Gln Ala Asn Thr Glu Glu Arg 
    290                 295                 300                 


Lys Ala Ala Leu Lys Thr Ala Ser Asp Phe Ile Thr Lys Met Asp Tyr 
305                 310                 315                 320 


Pro Lys Gln Thr Gln Val Ser Val Leu Pro Glu Gly Gly Glu Thr Pro 
                325                 330                 335     


Leu Phe Lys Gln Phe Phe Lys Asn Trp Arg Asp Pro Asp Gln Thr Asp 
            340                 345                 350         


Gly Leu Gly Leu Ser Tyr Leu Ser Ser His Ile Ala Asn Val Glu Arg 
        355                 360                 365             


Val Pro Phe Asp Ala Ala Thr Leu His Thr Ser Thr Ala Met Ala Ala 
    370                 375                 380                 


Gln His Gly Met Asp Asp Asp Gly Thr Gly Gln Lys Gln Ile Trp Arg 
385                 390                 395                 400 


Ile Glu Gly Ser Asn Lys Val Pro Val Asp Pro Ala Thr Tyr Gly Gln 
                405                 410                 415     


Phe Tyr Gly Gly Asp Ser Tyr Ile Ile Leu Tyr Asn Tyr Arg His Gly 
            420                 425                 430         


Gly Arg Gln Gly Gln Ile Ile Tyr Asn Trp Gln Gly Ala Gln Ser Thr 
        435                 440                 445             


Gln Asp Glu Val Ala Ala Ser Ala Ile Leu Thr Ala Gln Leu Asp Glu 
    450                 455                 460                 


Glu Leu Gly Gly Thr Pro Val Gln Ser Arg Val Val Gln Gly Lys Glu 
465                 470                 475                 480 


Pro Ala His Leu Met Ser Leu Phe Gly Gly Lys Pro Met Ile Ile Tyr 
                485                 490                 495     


Lys Gly Gly Thr Ser Arg Glu Gly Gly Gln Thr Ala Pro Ala Ser Thr 
            500                 505                 510         


Arg Leu Phe Gln Val Arg Ala Asn Ser Ala Gly Ala Thr Arg Ala Val 
        515                 520                 525             


Glu Val Leu Pro Lys Ala Gly Ala Leu Asn Ser Asn Asp Ala Phe Val 
    530                 535                 540                 


Leu Lys Thr Pro Ser Ala Ala Tyr Leu Trp Val Gly Thr Gly Ala Ser 
545                 550                 555                 560 


Glu Ala Glu Lys Thr Gly Ala Gln Glu Leu Leu Arg Val Leu Arg Ala 
                565                 570                 575     


Gln Pro Val Gln Val Ala Glu Gly Ser Glu Pro Asp Gly Phe Trp Glu 
            580                 585                 590         


Ala Leu Gly Gly Lys Ala Ala Tyr Arg Thr Ser Pro Arg Leu Lys Asp 
        595                 600                 605             


Lys Lys Met Asp Ala His Pro Pro Arg Leu Phe Ala Cys Ser Asn Lys 
    610                 615                 620                 


Ile Gly Arg Phe Val Ile Glu Glu Val Pro Gly Glu Leu Met Gln Glu 
625                 630                 635                 640 


Asp Leu Ala Thr Asp Asp Val Met Leu Leu Asp Thr Trp Asp Gln Val 
                645                 650                 655     


Phe Val Trp Val Gly Lys Asp Ser Gln Glu Glu Glu Lys Thr Glu Ala 
            660                 665                 670         


Leu Thr Ser Ala Lys Arg Tyr Ile Glu Thr Asp Pro Ala Asn Arg Asp 
        675                 680                 685             


Arg Arg Thr Pro Ile Thr Val Val Lys Gln Gly Phe Glu Pro Pro Ser 
    690                 695                 700                 


Phe Val Gly Trp Phe Leu Gly Trp Asp Asp Asp Tyr Trp Ser Val Asp 
705                 710                 715                 720 


Pro Leu Asp Arg Ala Met Ala Glu Leu Ala Ala 
                725                 730     


<210>  6296
<211>  260
<212>  PRT
<213>  Homo Sapiens

<400>  6296

Met Val Val Glu His Pro Glu Phe Leu Lys Ala Gly Lys Glu Pro Gly 
1               5                   10                  15      


Leu Gln Ile Trp Arg Val Glu Lys Phe Asp Leu Val Pro Val Pro Thr 
            20                  25                  30          


Asn Leu Tyr Gly Asp Phe Phe Thr Gly Asp Ala Tyr Val Ile Leu Lys 
        35                  40                  45              


Thr Val Gln Leu Arg Asn Gly Asn Leu Gln Tyr Asp Leu His Tyr Trp 
    50                  55                  60                  


Leu Gly Asn Glu Cys Ser Gln Asp Glu Ser Gly Ala Ala Ala Ile Phe 
65                  70                  75                  80  


Thr Val Gln Leu Asp Asp Tyr Leu Asn Gly Arg Ala Val Gln His Arg 
                85                  90                  95      


Glu Val Gln Gly Phe Glu Ser Ala Thr Phe Leu Gly Tyr Phe Lys Ser 
            100                 105                 110         


Gly Leu Lys Tyr Lys Lys Gly Gly Val Ala Ser Gly Phe Lys His Val 
        115                 120                 125             


Val Pro Asn Glu Val Val Val Gln Arg Leu Phe Gln Val Lys Gly Arg 
    130                 135                 140                 


Arg Val Val Arg Ala Thr Glu Val Pro Val Ser Trp Glu Ser Phe Asn 
145                 150                 155                 160 


Asn Gly Asp Cys Phe Ile Leu Asp Leu Gly Asn Asn Ile His Gln Trp 
                165                 170                 175     


Cys Gly Ser Asn Ser Asn Arg Tyr Glu Arg Leu Lys Ala Thr Gln Val 
            180                 185                 190         


Ser Lys Gly Ile Arg Asp Asn Glu Arg Ser Gly Arg Ala Arg Val His 
        195                 200                 205             


Val Ser Glu Glu Gly Thr Glu Pro Glu Ala Met Leu Gln Val Leu Gly 
    210                 215                 220                 


Pro Lys Pro Ala Leu Pro Ala Gly Thr Glu Asp Thr Ala Lys Glu Asp 
225                 230                 235                 240 


Ala Ala Asn Arg Lys Leu Ala Lys Leu Tyr Lys Val Ser Asn Gly Ala 
                245                 250                 255     


Gly Thr Met Ser 
            260 


<210>  6297
<211>  67
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6297

Xaa Lys Gly Gly Thr Ser Arg Glu Gly Gly Gln Thr Ala Pro Ala Ser 
1               5                   10                  15      


Thr Arg Leu Phe Gln Val Arg Ala Asn Ser Ala Gly Ala Thr Arg Ala 
            20                  25                  30          


Val Glu Val Ile Ser Arg Ser Trp Asn Thr Glu Gly Ile Gly Leu Pro 
        35                  40                  45              


Glu Thr Ser Gln Leu Asn Asp Gln Ile Ser Arg His Arg Asn Gly Gly 
    50                  55                  60                  


Arg Gly Trp 
65          


<210>  6298
<211>  329
<212>  PRT
<213>  Homo Sapiens

<400>  6298

Met Glu Ser Phe Leu Thr Ser Met Gly Lys Phe Met Lys Leu Ile Pro 
1               5                   10                  15      


Asp His Arg Pro Lys Asp Leu Glu Ser Ile Ile Arg Pro Lys Cys Gln 
            20                  25                  30          


Val Ile Tyr Phe Pro Ile Arg Phe Pro Asp Val Ser Arg Phe Met Pro 
        35                  40                  45              


Lys His Lys Thr Thr His Leu Lys Lys Met Leu Gly Leu Lys Gly Asn 
    50                  55                  60                  


Gly Gly Ala Val Leu Ser Met Ala Leu Pro Phe Gln Pro Glu Gln Arg 
65                  70                  75                  80  


Asp Ser Glu Asp Leu Leu Lys Asn Phe Asn Ser Glu Cys Asp Thr His 
                85                  90                  95      


Cys Gly Leu Asp Thr Ala Arg Gln Glu Tyr Leu Gly Asn Ser Leu Arg 
            100                 105                 110         


Gln Glu Ser Asp Leu Lys Lys Ser Thr Ser Ser Asp Asn Ser Ser Ser 
        115                 120                 125             


His His Gly Glu Asn Lys Gln Asn Leu Thr Val Asp Pro Cys Asp Ile 
    130                 135                 140                 


Leu Gly Gly Val Asp Asn Gln Gln Arg Leu Leu His Ile Val Trp Pro 
145                 150                 155                 160 


His Arg Trp Glu His Asp Lys Asp Pro Glu Ser Phe Phe Lys Val Leu 
                165                 170                 175     


Met His Leu Lys Asp Leu Gly Leu Asn Phe His Val Ser Val Leu Gly 
            180                 185                 190         


Glu Thr Phe Thr Asp Val Pro Asp Ile Phe Ser Glu Ala Lys Lys Ala 
        195                 200                 205             


Leu Gly Ser Ser Val Leu His Trp Gly Tyr Leu Pro Ser Lys Asp Asp 
    210                 215                 220                 


Tyr Phe Gln Val Leu Cys Met Ala Asp Val Val Ile Ser Thr Ala Lys 
225                 230                 235                 240 


His Glu Phe Phe Gly Val Ala Met Leu Glu Ala Val Tyr Cys Gly Cys 
                245                 250                 255     


Tyr Pro Leu Cys Pro Lys Asp Leu Val Tyr Pro Glu Ile Phe Pro Ala 
            260                 265                 270         


Glu Tyr Leu Tyr Ser Thr Pro Glu Gln Leu Ser Lys Arg Leu Gln Asn 
        275                 280                 285             


Phe Cys Lys Arg Pro Asp Ile Ile Arg Lys His Leu Tyr Lys Gly Glu 
    290                 295                 300                 


Ile Ala Pro Phe Ser Trp Ala Ala Leu His Gly Lys Phe Arg Ser Leu 
305                 310                 315                 320 


Leu Thr Thr Glu Pro Arg Glu Asp Leu 
                325                 


<210>  6299
<211>  426
<212>  PRT
<213>  Homo Sapiens

<400>  6299

Met Leu Thr Leu His Val Trp Ile Trp Phe Gly Phe Met Pro Cys Pro 
1               5                   10                  15      


Asn Leu Met Gln Asn Tyr Asn His Gln Cys Cys Arg Thr Leu Phe Ala 
            20                  25                  30          


Ser Ser Val Leu Asn Leu Thr Glu Leu Ala Ala Leu Arg Pro Asp Leu 
        35                  40                  45              


Gly Lys Leu Lys Lys Ile Leu Tyr Phe His Glu Asn Gln Leu Ile Tyr 
    50                  55                  60                  


Pro Val Lys Lys Cys Gln Glu Arg Asp Phe Gln Tyr Gly Tyr Asn Gln 
65                  70                  75                  80  


Ile Leu Ser Cys Leu Val Ala Asp Val Val Val Phe Asn Ser Val Phe 
                85                  90                  95      


Asn Met Glu Ser Phe Leu Thr Ser Met Gly Lys Phe Met Lys Leu Ile 
            100                 105                 110         


Pro Asp His Arg Pro Lys Asp Leu Glu Ser Ile Ile Arg Pro Lys Cys 
        115                 120                 125             


Gln Val Ile Tyr Phe Pro Ile Arg Phe Pro Asp Val Ser Arg Phe Met 
    130                 135                 140                 


Pro Lys His Lys Thr Thr His Leu Lys Lys Met Leu Gly Leu Lys Gly 
145                 150                 155                 160 


Asn Gly Gly Ala Val Leu Ser Met Ala Leu Pro Phe Gln Pro Glu Gln 
                165                 170                 175     


Arg Asp Ser Glu Asp Leu Leu Lys Asn Phe Asn Ser Glu Cys Asp Thr 
            180                 185                 190         


His Cys Gly Leu Asp Thr Ala Arg Gln Glu Tyr Leu Gly Asn Ser Leu 
        195                 200                 205             


Arg Gln Glu Ser Asp Leu Lys Lys Ser Thr Ser Ser Asp Asn Ser Ser 
    210                 215                 220                 


Ser His His Gly Glu Asn Lys Gln Asn Leu Thr Val Asp Pro Cys Asp 
225                 230                 235                 240 


Ile Leu Gly Gly Val Asp Asn Gln Gln Arg Leu Leu His Ile Val Trp 
                245                 250                 255     


Pro His Arg Trp Glu His Asp Lys Asp Pro Glu Ser Phe Phe Lys Val 
            260                 265                 270         


Leu Met His Leu Lys Asp Leu Gly Leu Asn Phe His Val Ser Val Leu 
        275                 280                 285             


Gly Glu Thr Phe Thr Asp Val Pro Asp Ile Phe Ser Glu Ala Lys Lys 
    290                 295                 300                 


Ala Leu Gly Ser Ser Val Leu His Trp Gly Tyr Leu Pro Ser Lys Asp 
305                 310                 315                 320 


Asp Tyr Phe Gln Val Leu Cys Met Ala Asp Val Val Ile Ser Thr Ala 
                325                 330                 335     


Lys His Glu Phe Phe Gly Val Ala Met Leu Glu Ala Val Tyr Cys Gly 
            340                 345                 350         


Cys Tyr Pro Leu Cys Pro Lys Asp Leu Val Tyr Pro Glu Ile Phe Pro 
        355                 360                 365             


Ala Glu Tyr Leu Tyr Ser Thr Pro Glu Gln Leu Ser Lys Arg Leu Gln 
    370                 375                 380                 


Asn Phe Cys Lys Arg Pro Asp Ile Ile Arg Lys His Leu Tyr Lys Gly 
385                 390                 395                 400 


Glu Ile Ala Pro Phe Ser Trp Ala Ala Leu His Gly Lys Phe Arg Ser 
                405                 410                 415     


Leu Leu Thr Thr Glu Pro Arg Glu Asp Leu 
            420                 425     


<210>  6300
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  6300

Met Ser Ile Leu Ile Ile Glu Ala Phe Tyr Gly Gly Ser His Lys Gln 
1               5                   10                  15      


Leu Val Asp Leu Leu Gln Glu Glu Leu Gly Asp Cys Val Val Tyr Thr 
            20                  25                  30          


Leu Pro Ala Lys Lys Trp His Trp Arg Ala Arg Thr Ser Ala Leu Tyr 
        35                  40                  45              


Phe Ser Gln Thr Ile Pro Ile Ser Glu His Tyr Arg Gln Ser Glu Ile 
    50                  55                  60                  


Thr Asn 
65      


<210>  6301
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  6301

Met Ser Ile Leu Ile Ile Glu Ala Phe Tyr Gly Gly Ser His Lys Gln 
1               5                   10                  15      


Leu Val Asp Leu Leu Gln Glu Glu Leu Gly Asp Cys Val Val Tyr Thr 
            20                  25                  30          


Leu Pro Ala Lys Lys Trp His Trp Arg Ala Arg Thr Ser Ala Leu Tyr 
        35                  40                  45              


Phe Ser Gln Thr Ile Pro Ile Ser Glu His Tyr Arg Gln Ser Glu Ile 
    50                  55                  60                  


Thr Asn 
65      


<210>  6302
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  6302

Met Ser Ile Leu Ile Ile Glu Ala Phe Tyr Gly Gly Ser His Lys Gln 
1               5                   10                  15      


Leu Val Asp Leu Leu Gln Glu Glu Leu Gly Asp Cys Val Val Tyr Thr 
            20                  25                  30          


Leu Pro Ala Lys Lys Trp His Trp Arg Ala Arg Thr Ser Ala Leu Tyr 
        35                  40                  45              


Phe Ser Gln Thr Ile Pro Ile Ser Glu His Tyr Arg Thr Leu Phe Ala 
    50                  55                  60                  


Ser Ser Val Leu Asn Leu Thr Glu Leu Ala Ala Leu Arg Pro Asp Leu 
65                  70                  75                  80  


Gly Lys Leu Lys Lys Ile Leu Tyr Phe His Glu Asn Gln Leu Ile Tyr 
                85                  90                  95      


Pro Val Lys 
            


<210>  6303
<211>  173
<212>  PRT
<213>  Homo Sapiens

<400>  6303

Met Ser Ile Leu Ile Ile Glu Ala Phe Tyr Gly Gly Ser His Lys Gln 
1               5                   10                  15      


Leu Val Asp Leu Leu Gln Glu Glu Leu Gly Asp Cys Val Val Tyr Thr 
            20                  25                  30          


Leu Pro Ala Lys Lys Trp His Trp Arg Ala Arg Thr Ser Ala Leu Tyr 
        35                  40                  45              


Phe Ser Gln Thr Ile Pro Ile Ser Glu His Tyr Arg Thr Leu Phe Ala 
    50                  55                  60                  


Ser Ser Val Leu Asn Leu Thr Glu Leu Ala Ala Leu Arg Pro Asp Leu 
65                  70                  75                  80  


Gly Lys Leu Lys Lys Ile Leu Tyr Phe His Glu Asn Gln Leu Ile Tyr 
                85                  90                  95      


Pro Val Lys Lys Cys Gln Glu Arg Asp Phe Gln Tyr Gly Tyr Asn Gln 
            100                 105                 110         


Ile Leu Ser Cys Leu Val Ala Asp Val Val Val Phe Asn Ser Val Phe 
        115                 120                 125             


Asn Met Glu Ser Phe Leu Thr Ser Met Gly Lys Phe Met Lys Leu Ile 
    130                 135                 140                 


Pro Asp His Arg Pro Lys Asp Leu Glu Ser Ile Ile Arg Pro Lys Cys 
145                 150                 155                 160 


Gln Val Ile Tyr Phe Pro Ile Arg Phe Pro Asp Val Ser 
                165                 170             


<210>  6304
<211>  340
<212>  PRT
<213>  Homo Sapiens

<400>  6304

Met Ser Ile Leu Ile Ile Glu Ala Phe Tyr Gly Gly Ser His Lys Gln 
1               5                   10                  15      


Leu Val Asp Leu Leu Gln Glu Glu Leu Gly Asp Cys Val Val Tyr Thr 
            20                  25                  30          


Leu Pro Ala Lys Lys Trp His Trp Arg Ala Arg Thr Ser Ala Leu Tyr 
        35                  40                  45              


Phe Ser Gln Thr Ile Pro Ile Ser Glu His Tyr Arg Thr Leu Phe Ala 
    50                  55                  60                  


Ser Ser Val Leu Asn Leu Thr Glu Leu Ala Ala Leu Arg Pro Asp Leu 
65                  70                  75                  80  


Gly Lys Leu Lys Lys Ile Leu Tyr Phe His Glu Asn Gln Leu Ile Tyr 
                85                  90                  95      


Pro Val Lys Lys Cys Gln Glu Arg Asp Phe Gln Tyr Gly Tyr Asn Gln 
            100                 105                 110         


Ile Leu Ser Cys Leu Val Ala Asp Val Val Val Phe Asn Ser Val Phe 
        115                 120                 125             


Asn Met Glu Ser Phe Leu Thr Ser Met Gly Lys Phe Met Lys Leu Ile 
    130                 135                 140                 


Pro Asp His Arg Pro Lys Asp Leu Glu Ser Ile Ile Arg Pro Lys Cys 
145                 150                 155                 160 


Gln Val Ile Tyr Phe Pro Ile Arg Phe Pro Asp Val Ser Arg Glu His 
                165                 170                 175     


Asp Lys Asp Pro Glu Ser Phe Phe Lys Val Leu Met His Leu Lys Asp 
            180                 185                 190         


Leu Gly Leu Asn Phe His Val Ser Val Leu Gly Glu Thr Phe Thr Asp 
        195                 200                 205             


Val Pro Asp Ile Phe Ser Glu Ala Lys Lys Ala Leu Gly Ser Ser Val 
    210                 215                 220                 


Leu His Trp Gly Tyr Leu Pro Ser Lys Asp Asp Tyr Phe Gln Val Leu 
225                 230                 235                 240 


Cys Met Ala Asp Val Val Ile Ser Thr Ala Lys His Glu Phe Phe Gly 
                245                 250                 255     


Val Ala Met Leu Glu Ala Val Tyr Cys Gly Cys Tyr Pro Leu Cys Pro 
            260                 265                 270         


Lys Asp Leu Val Tyr Pro Glu Ile Phe Pro Ala Glu Tyr Leu Tyr Ser 
        275                 280                 285             


Thr Pro Glu Gln Leu Ser Lys Arg Leu Gln Asn Phe Cys Lys Arg Pro 
    290                 295                 300                 


Asp Ile Ile Arg Lys His Leu Tyr Lys Gly Glu Ile Ala Pro Phe Ser 
305                 310                 315                 320 


Trp Ala Ala Leu His Gly Lys Phe Arg Ser Leu Leu Thr Thr Glu Pro 
                325                 330                 335     


Arg Glu Asp Leu 
            340 


<210>  6305
<211>  376
<212>  PRT
<213>  Homo Sapiens

<400>  6305

Met Ser Ile Leu Ile Ile Glu Ala Phe Tyr Gly Gly Ser His Lys Gln 
1               5                   10                  15      


Leu Val Asp Leu Leu Gln Glu Glu Leu Gly Asp Cys Val Val Tyr Thr 
            20                  25                  30          


Leu Pro Ala Lys Lys Trp His Trp Arg Ala Arg Thr Ser Ala Leu Tyr 
        35                  40                  45              


Phe Ser Gln Thr Ile Pro Ile Ser Glu His Tyr Arg Thr Leu Phe Ala 
    50                  55                  60                  


Ser Ser Val Leu Asn Leu Thr Glu Leu Ala Ala Leu Arg Pro Asp Leu 
65                  70                  75                  80  


Gly Lys Leu Lys Lys Ile Leu Tyr Phe His Glu Asn Gln Leu Ile Tyr 
                85                  90                  95      


Pro Val Lys Lys Cys Gln Glu Arg Asp Phe Gln Tyr Gly Tyr Asn Gln 
            100                 105                 110         


Ile Leu Ser Cys Leu Val Ala Asp Val Val Val Phe Asn Ser Val Phe 
        115                 120                 125             


Asn Met Glu Ser Phe Leu Thr Ser Met Gly Lys Phe Met Lys Leu Ile 
    130                 135                 140                 


Pro Asp His Arg Pro Lys Asp Leu Glu Ser Ile Ile Arg Pro Lys Cys 
145                 150                 155                 160 


Gln Val Ile Tyr Phe Pro Ile Arg Phe Pro Asp Val Ser Arg Phe Met 
                165                 170                 175     


Pro Lys His Lys Thr Thr His Leu Lys Lys Met Leu Gly Leu Lys Gly 
            180                 185                 190         


Asn Gly Gly Ala Val Leu Ser Met Ala Leu Pro Phe Gln Pro Glu Gln 
        195                 200                 205             


Arg Asp Ser Glu Asp Leu Leu Lys Asn Phe Asn Ser Glu Cys Asp Thr 
    210                 215                 220                 


His Cys Gly Leu Asp Thr Ala Arg Gln Glu Tyr Leu Gly Asn Ser Leu 
225                 230                 235                 240 


Arg Gln Glu Ser Asp Leu Lys Lys Ser Thr Ser Ser Asp Asn Ser Ser 
                245                 250                 255     


Ser His His Gly Glu Asn Lys Gln Asn Leu Thr Val Asp Pro Cys Asp 
            260                 265                 270         


Ile Leu Gly Gly Val Asp Asn Gln Gln Arg Leu Leu His Ile Val Trp 
        275                 280                 285             


Pro His Arg Trp Glu His Asp Lys Asp Pro Glu Ser Phe Phe Lys Val 
    290                 295                 300                 


Leu Met His Leu Lys Asp Leu Gly Leu Asn Phe His Val Ser Val Leu 
305                 310                 315                 320 


Gly Glu Thr Phe Thr Asp Val Pro Gly Trp Lys Leu Cys Thr Val Gly 
                325                 330                 335     


Val Thr His Phe Val Leu Lys Ile Trp Phe Ile Pro Lys Tyr Phe Gln 
            340                 345                 350         


Leu Asn Ile Cys Ile Leu His Leu Asn Ser Phe Gln Lys Gly Ser Arg 
        355                 360                 365             


Ile Ser Ala Arg Asp Gln Ile Leu 
    370                 375     


<210>  6306
<211>  458
<212>  PRT
<213>  Homo Sapiens

<400>  6306

Met Ser Ile Leu Ile Ile Glu Ala Phe Tyr Gly Gly Ser His Lys Gln 
1               5                   10                  15      


Leu Val Asp Leu Leu Gln Glu Glu Leu Gly Asp Cys Val Val Tyr Thr 
            20                  25                  30          


Leu Pro Ala Lys Lys Trp His Trp Arg Ala Arg Thr Ser Ala Leu Tyr 
        35                  40                  45              


Phe Ser Gln Thr Ile Pro Ile Ser Glu His Tyr Arg Thr Leu Phe Ala 
    50                  55                  60                  


Ser Ser Val Leu Asn Leu Thr Glu Leu Ala Ala Leu Arg Pro Asp Leu 
65                  70                  75                  80  


Gly Lys Leu Lys Lys Ile Leu Tyr Phe His Glu Asn Gln Leu Ile Tyr 
                85                  90                  95      


Pro Val Lys Lys Cys Gln Glu Arg Asp Phe Gln Tyr Gly Tyr Asn Gln 
            100                 105                 110         


Ile Leu Ser Cys Leu Val Ala Asp Val Val Val Phe Asn Ser Val Phe 
        115                 120                 125             


Asn Met Glu Ser Phe Leu Thr Ser Met Gly Lys Phe Met Lys Leu Ile 
    130                 135                 140                 


Pro Asp His Arg Pro Lys Asp Leu Glu Ser Ile Ile Arg Pro Lys Cys 
145                 150                 155                 160 


Gln Val Ile Tyr Phe Pro Ile Arg Phe Pro Asp Val Ser Arg Phe Met 
                165                 170                 175     


Pro Lys His Lys Thr Thr His Leu Lys Lys Met Leu Gly Leu Lys Gly 
            180                 185                 190         


Asn Gly Gly Ala Val Leu Ser Met Ala Leu Pro Phe Gln Pro Glu Gln 
        195                 200                 205             


Arg Asp Ser Glu Asp Leu Leu Lys Asn Phe Asn Ser Glu Cys Asp Thr 
    210                 215                 220                 


His Cys Gly Leu Asp Thr Ala Arg Gln Glu Tyr Leu Gly Asn Ser Leu 
225                 230                 235                 240 


Arg Gln Glu Ser Asp Leu Lys Lys Ser Thr Ser Ser Asp Asn Ser Ser 
                245                 250                 255     


Ser His His Gly Glu Asn Lys Gln Asn Leu Thr Val Asp Pro Cys Asp 
            260                 265                 270         


Ile Leu Gly Gly Val Asp Asn Gln Gln Arg Leu Leu His Ile Val Trp 
        275                 280                 285             


Pro His Arg Trp Glu His Asp Lys Asp Pro Glu Ser Phe Phe Lys Val 
    290                 295                 300                 


Leu Met His Leu Lys Asp Leu Gly Leu Asn Phe His Val Ser Val Leu 
305                 310                 315                 320 


Gly Glu Thr Phe Thr Asp Val Pro Asp Ile Phe Ser Glu Ala Lys Lys 
                325                 330                 335     


Ala Leu Gly Ser Ser Val Leu His Trp Gly Tyr Leu Pro Ser Lys Asp 
            340                 345                 350         


Asp Tyr Phe Gln Val Leu Cys Met Ala Asp Val Val Ile Ser Thr Ala 
        355                 360                 365             


Lys His Glu Phe Phe Gly Val Ala Met Leu Glu Ala Val Tyr Cys Gly 
    370                 375                 380                 


Cys Tyr Pro Leu Cys Pro Lys Asp Leu Val Tyr Pro Glu Ile Phe Pro 
385                 390                 395                 400 


Ala Glu Tyr Leu Tyr Ser Thr Pro Glu Gln Leu Ser Lys Arg Leu Gln 
                405                 410                 415     


Asn Phe Cys Lys Arg Pro Asp Ile Ile Arg Lys His Leu Tyr Lys Gly 
            420                 425                 430         


Glu Ile Ala Pro Phe Ser Trp Ala Ala Leu His Gly Lys Phe Arg Ser 
        435                 440                 445             


Leu Leu Thr Thr Glu Pro Arg Glu Asp Leu 
    450                 455             


<210>  6307
<211>  373
<212>  PRT
<213>  Homo Sapiens

<400>  6307

Met Ser Ile Leu Ile Ile Glu Ala Phe Tyr Gly Gly Ser His Lys Gln 
1               5                   10                  15      


Leu Val Asp Leu Leu Gln Glu Glu Leu Gly Asp Cys Val Val Tyr Thr 
            20                  25                  30          


Leu Pro Ala Lys Lys Trp His Trp Arg Ala Arg Thr Ser Ala Leu Tyr 
        35                  40                  45              


Phe Ser Gln Thr Ile Pro Ile Ser Glu His Tyr Arg Thr Leu Phe Ala 
    50                  55                  60                  


Ser Ser Val Leu Asn Leu Thr Glu Leu Ala Ala Leu Arg Pro Asp Leu 
65                  70                  75                  80  


Gly Lys Leu Lys Lys Ile Leu Tyr Phe His Glu Asn Gln Leu Ile Tyr 
                85                  90                  95      


Pro Val Lys Lys Cys Gln Glu Arg Asp Phe Gln Tyr Gly Tyr Asn Gln 
            100                 105                 110         


Ile Leu Ser Cys Leu Val Ala Asp Val Val Val Phe Asn Ser Val Phe 
        115                 120                 125             


Asn Met Glu Ser Phe Leu Thr Ser Met Gly Lys Phe Met Lys Leu Ile 
    130                 135                 140                 


Pro Asp His Arg Pro Lys Asp Leu Glu Ser Ile Ile Arg Pro Lys Cys 
145                 150                 155                 160 


Gln Val Ile Tyr Phe Pro Ile Arg Phe Pro Asp Val Ser Arg Phe Met 
                165                 170                 175     


Pro Lys His Lys Thr Thr His Leu Lys Lys Met Leu Gly Leu Lys Gly 
            180                 185                 190         


Asn Gly Gly Ala Val Leu Ser Met Ala Leu Pro Phe Gln Pro Glu Gln 
        195                 200                 205             


Arg Asp Ser Glu Asp Leu Leu Lys Asn Phe Asn Ser Glu Cys Asp Thr 
    210                 215                 220                 


His Cys Gly Leu Asp Thr Ala Arg Gln Glu Tyr Leu Gly Asn Ser Leu 
225                 230                 235                 240 


Arg Gln Glu Ser Asp Leu Lys Lys Ser Thr Ser Ser Asp Asn Ser Ser 
                245                 250                 255     


Ser His His Gly Glu Asn Lys Gln Asn Leu Thr Val Asp Pro Cys Asp 
            260                 265                 270         


Ile Leu Gly Gly Val Asp Asn Gln Gln Arg Leu Leu His Ile Val Trp 
        275                 280                 285             


Pro His Arg Trp Leu Glu Ala Val Tyr Cys Gly Cys Tyr Pro Leu Cys 
    290                 295                 300                 


Pro Lys Asp Leu Val Tyr Pro Glu Ile Phe Pro Ala Glu Tyr Leu Tyr 
305                 310                 315                 320 


Ser Thr Pro Glu Gln Leu Ser Lys Arg Leu Gln Asn Phe Cys Lys Arg 
                325                 330                 335     


Pro Asp Ile Ile Arg Lys His Leu Tyr Lys Gly Glu Ile Ala Pro Phe 
            340                 345                 350         


Ser Trp Ala Ala Leu His Gly Lys Phe Arg Ser Leu Leu Thr Thr Glu 
        355                 360                 365             


Pro Arg Glu Asp Leu 
    370             


<210>  6308
<211>  376
<212>  PRT
<213>  Homo Sapiens

<400>  6308

Met Ser Ile Leu Ile Ile Glu Ala Phe Tyr Gly Gly Ser His Lys Gln 
1               5                   10                  15      


Leu Val Asp Leu Leu Gln Glu Glu Leu Gly Asp Cys Val Val Tyr Thr 
            20                  25                  30          


Leu Pro Ala Lys Lys Trp His Trp Arg Ala Arg Thr Ser Ala Leu Tyr 
        35                  40                  45              


Phe Ser Gln Thr Ile Pro Ile Ser Glu His Tyr Arg Thr Leu Phe Ala 
    50                  55                  60                  


Ser Ser Val Leu Asn Leu Thr Glu Leu Ala Ala Leu Arg Pro Asp Leu 
65                  70                  75                  80  


Gly Lys Leu Lys Lys Ile Leu Tyr Phe His Glu Asn Gln Leu Ile Tyr 
                85                  90                  95      


Pro Val Lys Lys Cys Gln Glu Arg Asp Phe Gln Tyr Gly Tyr Asn Gln 
            100                 105                 110         


Ile Leu Ser Cys Leu Val Ala Asp Val Val Val Phe Asn Ser Val Phe 
        115                 120                 125             


Asn Met Glu Ser Phe Leu Thr Ser Met Gly Lys Phe Met Lys Leu Ile 
    130                 135                 140                 


Pro Asp His Arg Pro Lys Asp Leu Glu Ser Ile Ile Arg Pro Lys Cys 
145                 150                 155                 160 


Gln Val Ile Tyr Phe Pro Ile Arg Phe Pro Asp Val Ser Arg Phe Met 
                165                 170                 175     


Pro Lys His Lys Thr Thr His Leu Lys Lys Met Leu Gly Leu Lys Gly 
            180                 185                 190         


Asn Gly Gly Ala Val Leu Ser Met Ala Leu Pro Phe Gln Pro Glu Gln 
        195                 200                 205             


Arg Asp Ser Glu Asp Leu Leu Lys Asn Phe Asn Ser Glu Cys Asp Thr 
    210                 215                 220                 


His Cys Gly Leu Asp Thr Ala Arg Gln Glu Tyr Leu Gly Asn Ser Leu 
225                 230                 235                 240 


Arg Gln Glu Ser Asp Leu Lys Lys Ser Thr Ser Ser Asp Asn Ser Ser 
                245                 250                 255     


Ser His His Gly Glu Asn Lys Gln Asn Leu Thr Val Asp Pro Cys Asp 
            260                 265                 270         


Ile Leu Gly Gly Val Asp Asn Gln Gln Arg Leu Leu His Ile Val Trp 
        275                 280                 285             


Pro His Arg Trp Glu His Asp Lys Asp Pro Glu Ser Phe Phe Lys Val 
    290                 295                 300                 


Leu Met His Leu Lys Asp Leu Gly Leu Asn Phe His Val Ser Val Leu 
305                 310                 315                 320 


Gly Glu Thr Phe Thr Asp Val Pro Gly Trp Lys Leu Cys Thr Val Gly 
                325                 330                 335     


Val Thr His Phe Val Leu Lys Ile Trp Phe Ile Pro Lys Tyr Phe Gln 
            340                 345                 350         


Leu Asn Ile Cys Ile Leu His Leu Asn Ser Phe Gln Lys Gly Ser Arg 
        355                 360                 365             


Ile Ser Ala Arg Asp Gln Ile Leu 
    370                 375     


<210>  6309
<211>  458
<212>  PRT
<213>  Homo Sapiens

<400>  6309

Met Ser Ile Leu Ile Ile Glu Ala Phe Tyr Gly Gly Ser His Lys Gln 
1               5                   10                  15      


Leu Val Asp Leu Leu Gln Glu Glu Leu Gly Asp Cys Val Val Tyr Thr 
            20                  25                  30          


Leu Pro Ala Lys Lys Trp His Trp Arg Ala Arg Thr Ser Ala Leu Tyr 
        35                  40                  45              


Phe Ser Gln Thr Ile Pro Ile Ser Glu His Tyr Arg Thr Leu Phe Ala 
    50                  55                  60                  


Ser Ser Val Leu Asn Leu Thr Glu Leu Ala Ala Leu Arg Pro Asp Leu 
65                  70                  75                  80  


Gly Lys Leu Lys Lys Ile Leu Tyr Phe His Glu Asn Gln Leu Ile Tyr 
                85                  90                  95      


Pro Val Lys Lys Cys Gln Glu Arg Asp Phe Gln Tyr Gly Tyr Asn Gln 
            100                 105                 110         


Ile Leu Ser Cys Leu Val Ala Asp Val Val Val Phe Asn Ser Val Phe 
        115                 120                 125             


Asn Met Glu Ser Phe Leu Thr Ser Met Gly Lys Phe Met Lys Leu Ile 
    130                 135                 140                 


Pro Asp His Arg Pro Lys Asp Leu Glu Ser Ile Ile Arg Pro Lys Cys 
145                 150                 155                 160 


Gln Val Ile Tyr Phe Pro Ile Arg Phe Pro Asp Val Ser Arg Phe Met 
                165                 170                 175     


Pro Lys His Lys Thr Thr His Leu Lys Lys Met Leu Gly Leu Lys Gly 
            180                 185                 190         


Asn Gly Gly Ala Val Leu Ser Met Ala Leu Pro Phe Gln Pro Glu Gln 
        195                 200                 205             


Arg Asp Ser Glu Asp Leu Leu Lys Asn Phe Asn Ser Glu Cys Asp Thr 
    210                 215                 220                 


His Cys Gly Leu Asp Thr Ala Arg Gln Glu Tyr Leu Gly Asn Ser Leu 
225                 230                 235                 240 


Arg Gln Glu Ser Asp Leu Lys Lys Ser Thr Ser Ser Asp Asn Ser Ser 
                245                 250                 255     


Ser His His Gly Glu Asn Lys Gln Asn Leu Thr Val Asp Pro Cys Asp 
            260                 265                 270         


Ile Leu Gly Gly Val Asp Asn Gln Gln Arg Leu Leu His Ile Val Trp 
        275                 280                 285             


Pro His Arg Trp Glu His Asp Lys Asp Pro Glu Ser Phe Phe Lys Val 
    290                 295                 300                 


Leu Met His Leu Lys Asp Leu Gly Leu Asn Phe His Val Ser Val Leu 
305                 310                 315                 320 


Gly Glu Thr Phe Thr Asp Val Pro Asp Ile Phe Ser Glu Ala Lys Lys 
                325                 330                 335     


Ala Leu Gly Ser Ser Val Leu His Trp Gly Tyr Leu Pro Ser Lys Asp 
            340                 345                 350         


Asp Tyr Phe Gln Val Leu Cys Met Ala Asp Val Val Ile Ser Thr Ala 
        355                 360                 365             


Lys His Glu Phe Phe Gly Val Ala Met Leu Glu Ala Val Tyr Cys Gly 
    370                 375                 380                 


Cys Tyr Pro Leu Cys Pro Lys Asp Leu Val Tyr Pro Glu Ile Phe Pro 
385                 390                 395                 400 


Ala Glu Tyr Leu Tyr Ser Thr Pro Glu Gln Leu Ser Lys Arg Leu Gln 
                405                 410                 415     


Asn Phe Cys Lys Arg Pro Asp Ile Ile Arg Lys His Leu Tyr Lys Gly 
            420                 425                 430         


Glu Ile Ala Pro Phe Ser Trp Ala Ala Leu His Gly Lys Phe Arg Ser 
        435                 440                 445             


Leu Leu Thr Thr Glu Pro Arg Glu Asp Leu 
    450                 455             


<210>  6310
<211>  458
<212>  PRT
<213>  Homo Sapiens

<400>  6310

Met Ser Ile Leu Ile Ile Glu Ala Phe Tyr Gly Gly Ser His Lys Gln 
1               5                   10                  15      


Leu Val Asp Leu Leu Gln Glu Glu Leu Gly Asp Cys Val Val Tyr Thr 
            20                  25                  30          


Leu Pro Ala Lys Lys Trp His Trp Arg Ala Arg Thr Ser Ala Leu Tyr 
        35                  40                  45              


Phe Ser Gln Thr Ile Pro Ile Ser Glu His Tyr Arg Thr Leu Phe Ala 
    50                  55                  60                  


Ser Ser Val Leu Asn Leu Thr Glu Leu Ala Ala Leu Arg Pro Asp Leu 
65                  70                  75                  80  


Gly Lys Leu Lys Lys Ile Leu Tyr Phe His Glu Asn Gln Leu Ile Tyr 
                85                  90                  95      


Pro Val Lys Lys Cys Gln Glu Arg Asp Phe Gln Tyr Gly Tyr Asn Gln 
            100                 105                 110         


Ile Leu Ser Cys Leu Val Ala Asp Val Val Val Phe Asn Ser Val Phe 
        115                 120                 125             


Asn Met Glu Ser Phe Leu Thr Ser Met Gly Lys Phe Met Lys Leu Ile 
    130                 135                 140                 


Pro Asp His Arg Pro Lys Asp Leu Glu Ser Ile Ile Arg Pro Lys Cys 
145                 150                 155                 160 


Gln Val Ile Tyr Phe Pro Ile Arg Phe Pro Asp Val Ser Arg Phe Met 
                165                 170                 175     


Pro Lys His Lys Thr Thr His Leu Lys Lys Met Leu Gly Leu Lys Gly 
            180                 185                 190         


Asn Gly Gly Ala Val Leu Ser Met Ala Leu Pro Phe Gln Pro Glu Gln 
        195                 200                 205             


Arg Asp Ser Glu Asp Leu Leu Lys Asn Phe Asn Ser Glu Cys Asp Thr 
    210                 215                 220                 


His Cys Gly Leu Asp Thr Ala Arg Gln Glu Tyr Leu Gly Asn Ser Leu 
225                 230                 235                 240 


Arg Gln Glu Ser Asp Leu Lys Lys Ser Thr Ser Ser Asp Asn Ser Ser 
                245                 250                 255     


Ser His His Gly Glu Asn Lys Gln Asn Leu Thr Val Asp Pro Cys Asp 
            260                 265                 270         


Ile Leu Gly Gly Val Asp Asn Gln Gln Arg Leu Leu His Ile Val Trp 
        275                 280                 285             


Pro His Arg Trp Glu His Asp Lys Asp Pro Glu Ser Phe Phe Lys Val 
    290                 295                 300                 


Leu Met His Leu Lys Asp Leu Gly Leu Asn Phe His Val Ser Val Leu 
305                 310                 315                 320 


Gly Glu Thr Phe Thr Asp Val Pro Asp Ile Phe Ser Glu Ala Lys Lys 
                325                 330                 335     


Ala Leu Gly Ser Ser Val Leu His Trp Gly Tyr Leu Pro Ser Lys Asp 
            340                 345                 350         


Asp Tyr Phe Gln Val Leu Cys Met Ala Asp Val Val Ile Ser Thr Ala 
        355                 360                 365             


Lys His Glu Phe Phe Gly Val Ala Met Leu Glu Ala Val Tyr Cys Gly 
    370                 375                 380                 


Cys Tyr Pro Leu Cys Pro Lys Asp Leu Val Tyr Pro Glu Ile Phe Pro 
385                 390                 395                 400 


Ala Glu Tyr Leu Tyr Ser Thr Pro Glu Gln Leu Ser Lys Arg Leu Gln 
                405                 410                 415     


Asn Phe Cys Lys Arg Pro Asp Ile Ile Arg Lys His Leu Tyr Lys Gly 
            420                 425                 430         


Glu Ile Ala Pro Phe Ser Trp Ala Ala Leu His Gly Lys Phe Arg Ser 
        435                 440                 445             


Leu Leu Thr Thr Glu Pro Arg Glu Asp Leu 
    450                 455             


<210>  6311
<211>  458
<212>  PRT
<213>  Homo Sapiens

<400>  6311

Met Ser Ile Leu Ile Ile Glu Ala Phe Tyr Gly Gly Ser His Lys Gln 
1               5                   10                  15      


Leu Val Asp Leu Leu Gln Glu Glu Leu Gly Asp Cys Val Val Tyr Thr 
            20                  25                  30          


Leu Pro Ala Lys Lys Trp His Trp Arg Ala Arg Thr Ser Ala Leu Tyr 
        35                  40                  45              


Phe Ser Gln Thr Ile Pro Ile Ser Glu His Tyr Arg Thr Leu Phe Ala 
    50                  55                  60                  


Ser Ser Val Leu Asn Leu Thr Glu Leu Ala Ala Leu Arg Pro Asp Leu 
65                  70                  75                  80  


Gly Lys Leu Lys Lys Ile Leu Tyr Phe His Glu Asn Gln Leu Ile Tyr 
                85                  90                  95      


Pro Val Lys Lys Cys Gln Glu Arg Asp Phe Gln Tyr Gly Tyr Asn Gln 
            100                 105                 110         


Ile Leu Ser Cys Leu Val Ala Asp Val Val Val Phe Asn Ser Val Phe 
        115                 120                 125             


Asn Met Glu Ser Phe Leu Thr Ser Met Gly Lys Phe Met Lys Leu Ile 
    130                 135                 140                 


Pro Asp His Arg Pro Lys Asp Leu Glu Ser Ile Ile Arg Pro Lys Cys 
145                 150                 155                 160 


Gln Val Ile Tyr Phe Pro Ile Arg Phe Pro Asp Val Ser Arg Phe Met 
                165                 170                 175     


Pro Lys His Lys Thr Thr His Leu Lys Lys Met Leu Gly Leu Lys Gly 
            180                 185                 190         


Asn Gly Gly Ala Val Leu Ser Met Ala Leu Pro Phe Gln Pro Glu Gln 
        195                 200                 205             


Arg Asp Ser Glu Asp Leu Leu Lys Asn Phe Asn Ser Glu Cys Asp Thr 
    210                 215                 220                 


His Cys Gly Leu Asp Thr Ala Arg Gln Glu Tyr Leu Gly Asn Ser Leu 
225                 230                 235                 240 


Arg Gln Glu Ser Asp Leu Lys Lys Ser Thr Ser Ser Asp Asn Ser Ser 
                245                 250                 255     


Ser His His Gly Glu Asn Lys Gln Asn Leu Thr Val Asp Pro Cys Asp 
            260                 265                 270         


Ile Leu Gly Gly Val Asp Asn Gln Gln Arg Leu Leu His Ile Val Trp 
        275                 280                 285             


Pro His Arg Trp Glu His Asp Lys Asp Pro Glu Ser Phe Phe Lys Val 
    290                 295                 300                 


Leu Met His Leu Lys Asp Leu Gly Leu Asn Phe His Val Ser Val Leu 
305                 310                 315                 320 


Gly Glu Thr Phe Thr Asp Val Pro Asp Ile Phe Ser Glu Ala Lys Lys 
                325                 330                 335     


Ala Leu Gly Ser Ser Val Leu His Trp Gly Tyr Leu Pro Ser Lys Asp 
            340                 345                 350         


Asp Tyr Phe Gln Val Leu Cys Met Ala Asp Val Val Ile Ser Thr Ala 
        355                 360                 365             


Lys His Glu Phe Phe Gly Val Ala Met Leu Glu Ala Val Tyr Cys Gly 
    370                 375                 380                 


Cys Tyr Pro Leu Cys Pro Lys Asp Leu Val Tyr Pro Glu Ile Phe Pro 
385                 390                 395                 400 


Ala Glu Tyr Leu Tyr Ser Thr Pro Glu Gln Leu Ser Lys Arg Leu Gln 
                405                 410                 415     


Asn Phe Cys Lys Arg Pro Asp Ile Ile Arg Lys His Leu Tyr Lys Gly 
            420                 425                 430         


Glu Ile Ala Pro Phe Ser Trp Ala Ala Leu His Gly Lys Phe Arg Ser 
        435                 440                 445             


Leu Leu Thr Thr Glu Pro Arg Glu Asp Leu 
    450                 455             


<210>  6312
<211>  236
<212>  PRT
<213>  Homo Sapiens

<400>  6312

Met Arg Thr Val Ser Leu Cys His Pro Asp Trp Ser Ala Leu Ala Ser 
1               5                   10                  15      


Ser Trp Leu Thr Ala Ala Ser Thr Ser Trp Ala Gln Tyr Gly Asn Phe 
            20                  25                  30          


Ile Asp Lys Leu Arg Leu Phe Thr Arg Gly Gly Ser Gly Gly Met Gly 
        35                  40                  45              


Tyr Pro Arg Leu Gly Gly Glu Gly Gly Lys Gly Gly Asp Val Trp Val 
    50                  55                  60                  


Val Ala Gln Asn Arg Met Thr Leu Lys Gln Leu Lys Asp Arg Tyr Pro 
65                  70                  75                  80  


Arg Lys Arg Phe Val Ala Gly Val Gly Ala Asn Ser Lys Ile Ser Ala 
                85                  90                  95      


Leu Lys Gly Ser Lys Gly Lys Asp Cys Glu Ile Pro Val Pro Val Gly 
            100                 105                 110         


Ile Ser Val Thr Asp Glu Asn Gly Lys Ile Ile Gly Glu Leu Asn Lys 
        115                 120                 125             


Glu Asn Asp Arg Ile Leu Val Ala Gln Gly Gly Leu Gly Gly Lys Leu 
    130                 135                 140                 


Leu Thr Asn Phe Leu Pro Leu Lys Gly Gln Lys Arg Ile Ile His Leu 
145                 150                 155                 160 


Asp Leu Lys Leu Ile Ala Asp Val Gly Leu Val Gly Phe Pro Asn Ala 
                165                 170                 175     


Gly Lys Ser Ser Leu Leu Ser Cys Val Ser His Ala Lys Pro Ala Ile 
            180                 185                 190         


Ala Asp Tyr Ala Phe Thr Thr Leu Lys Pro Glu Leu Gly Lys Ile Met 
        195                 200                 205             


Tyr Ser Asp Phe Lys Gln Ile Ser Val Ala Asp Leu Pro Gly Leu Ile 
    210                 215                 220                 


Glu Gly Ala His Met Asn Lys Gly Met Gly His Lys 
225                 230                 235     


<210>  6313
<211>  107
<212>  PRT
<213>  Homo Sapiens

<400>  6313

Met Arg Tyr Gly Asn Phe Ile Asp Lys Leu Arg Leu Phe Thr Arg Gly 
1               5                   10                  15      


Gly Ser Gly Gly Met Gly Tyr Pro Arg Leu Gly Gly Glu Gly Gly Lys 
            20                  25                  30          


Gly Gly Asp Val Trp Val Val Ala Gln Asn Arg Met Thr Leu Lys Gln 
        35                  40                  45              


Leu Lys Asp Arg Tyr Pro Arg Lys Arg Phe Val Ala Gly Val Gly Ala 
    50                  55                  60                  


Asn Ser Lys Ile Ser Ala Leu Lys Gly Ser Lys Gly Lys Asp Cys Glu 
65                  70                  75                  80  


Ile Pro Val Pro Val Gly Ile Ser Val Thr Asp Glu Asn Gly Lys Ile 
                85                  90                  95      


Ile Asp Ser Gln Met Leu Glu Asn Pro Leu Cys 
            100                 105         


<210>  6314
<211>  210
<212>  PRT
<213>  Homo Sapiens

<400>  6314

Met Arg Tyr Gly Asn Phe Ile Asp Lys Leu Arg Leu Phe Thr Arg Gly 
1               5                   10                  15      


Gly Ser Gly Gly Met Gly Tyr Pro Arg Leu Gly Gly Glu Gly Gly Lys 
            20                  25                  30          


Gly Gly Asp Val Trp Val Val Ala Gln Asn Arg Met Thr Leu Lys Gln 
        35                  40                  45              


Leu Lys Asp Arg Tyr Pro Arg Lys Arg Phe Val Ala Gly Val Gly Ala 
    50                  55                  60                  


Asn Ser Lys Ile Ser Ala Leu Lys Gly Ser Lys Gly Lys Asp Cys Glu 
65                  70                  75                  80  


Ile Pro Val Pro Val Gly Ile Ser Val Thr Asp Glu Asn Gly Lys Ile 
                85                  90                  95      


Ile Gly Glu Leu Asn Lys Glu Asn Asp Arg Ile Leu Val Ala Gln Gly 
            100                 105                 110         


Gly Leu Gly Gly Lys Leu Leu Thr Asn Phe Leu Pro Leu Lys Gly Gln 
        115                 120                 125             


Lys Arg Ile Ile His Leu Asp Leu Lys Leu Ile Ala Asp Val Gly Leu 
    130                 135                 140                 


Val Gly Phe Pro Asn Ala Gly Lys Ser Ser Leu Leu Ser Cys Val Ser 
145                 150                 155                 160 


His Ala Lys Pro Ala Ile Ala Asp Tyr Ala Phe Thr Thr Leu Lys Pro 
                165                 170                 175     


Glu Leu Gly Lys Ile Met Tyr Ser Asp Phe Lys Gln Ile Ser Val Ala 
            180                 185                 190         


Asp Leu Pro Gly Leu Ile Glu Gly Ala His Met Asn Lys Gly Met Gly 
        195                 200                 205             


His Lys 
    210 


<210>  6315
<211>  70
<212>  PRT
<213>  Homo Sapiens

<400>  6315

Met Arg Tyr Gly Asn Phe Ile Asp Lys Leu Arg Leu Phe Thr Arg Gly 
1               5                   10                  15      


Gly Ser Gly Gly Met Gly Tyr Pro Arg Leu Gly Gly Glu Gly Gly Lys 
            20                  25                  30          


Gly Gly Asp Val Trp Val Val Ala Gln Asn Arg Met Thr Leu Lys Gln 
        35                  40                  45              


Leu Lys Asp Arg Tyr Pro Arg Lys Arg Phe Val Ala Gly Val Gly Ala 
    50                  55                  60                  


Asn Ser Lys Arg Thr Gln 
65                  70  


<210>  6316
<211>  308
<212>  PRT
<213>  Homo Sapiens

<400>  6316

Met Val His Cys Ser Cys Val Leu Phe Arg Lys Tyr Gly Asn Phe Ile 
1               5                   10                  15      


Asp Lys Leu Arg Leu Phe Thr Arg Gly Gly Ser Gly Gly Met Gly Tyr 
            20                  25                  30          


Pro Arg Leu Gly Gly Glu Gly Gly Lys Gly Gly Asp Val Trp Val Val 
        35                  40                  45              


Ala Gln Asn Arg Met Thr Leu Lys Gln Leu Lys Asp Arg Tyr Pro Arg 
    50                  55                  60                  


Lys Arg Phe Val Ala Gly Val Gly Ala Asn Ser Lys Phe Pro Asn Ala 
65                  70                  75                  80  


Gly Lys Ser Ser Leu Leu Ser Cys Val Ser His Ala Lys Pro Ala Ile 
                85                  90                  95      


Ala Asp Tyr Ala Phe Thr Thr Leu Lys Pro Glu Leu Gly Lys Ile Met 
            100                 105                 110         


Tyr Ser Asp Phe Lys Gln Ile Ser Val Ala Asp Leu Pro Gly Leu Ile 
        115                 120                 125             


Glu Gly Ala His Met Asn Lys Gly Met Gly His Lys Phe Leu Lys His 
    130                 135                 140                 


Ile Glu Arg Thr Arg Gln Leu Leu Phe Val Val Asp Ile Ser Gly Phe 
145                 150                 155                 160 


Gln Leu Ser Ser His Thr Gln Tyr Arg Thr Ala Phe Glu Thr Ile Ile 
                165                 170                 175     


Leu Leu Thr Lys Glu Leu Glu Leu Tyr Lys Glu Glu Leu Gln Thr Lys 
            180                 185                 190         


Pro Ala Leu Leu Ala Val Asn Lys Met Asp Leu Pro Asp Ala Gln Asp 
        195                 200                 205             


Lys Phe His Glu Leu Met Ser Gln Leu Gln Asn Pro Lys Asp Phe Leu 
    210                 215                 220                 


His Leu Phe Glu Lys Asn Met Ile Pro Glu Arg Thr Val Glu Phe Gln 
225                 230                 235                 240 


His Ile Ile Pro Ile Ser Ala Val Thr Gly Glu Gly Ile Glu Glu Leu 
                245                 250                 255     


Lys Asn Cys Ile Arg Lys Ser Leu Asp Glu Gln Ala Asn Gln Glu Asn 
            260                 265                 270         


Asp Ala Leu His Lys Lys Gln Leu Leu Asn Leu Trp Ile Ser Asp Thr 
        275                 280                 285             


Met Ser Ser Thr Glu Pro Pro Ser Lys His Ala Val Thr Thr Ser Lys 
    290                 295                 300                 


Met Asp Ile Ile 
305             


<210>  6317
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  6317

Met Val His Cys Ser Cys Val Leu Phe Arg Lys Tyr Gly Asn Phe Ile 
1               5                   10                  15      


Asp Lys Leu Arg Leu Phe Thr Arg Gly Gly Ser Gly Gly Met Gly Tyr 
            20                  25                  30          


Pro Arg Leu Gly Gly Glu Gly Gly Lys Gly Gly Asp Val Trp Val Val 
        35                  40                  45              


Ala Gln Asn Arg Met Thr Leu Lys Gln Leu Lys Asp Arg Tyr Pro Arg 
    50                  55                  60                  


Lys Arg Phe Val Ala Gly Val Gly Ala Asn Ser Lys Ile Ser Ala Leu 
65                  70                  75                  80  


Lys Gly Ser Lys Gly Lys Asp Cys Glu Ile Pro Val Pro Val Gly Ile 
                85                  90                  95      


Ser Val Thr Asp Glu Asn Gly Lys Ile Ile Asp Ser Gln Met Leu Glu 
            100                 105                 110         


Asn Pro Leu Cys 
        115     


<210>  6318
<211>  387
<212>  PRT
<213>  Homo Sapiens

<400>  6318

Met Val His Cys Ser Cys Val Leu Phe Arg Lys Tyr Gly Asn Phe Ile 
1               5                   10                  15      


Asp Lys Leu Arg Leu Phe Thr Arg Gly Gly Ser Gly Gly Met Gly Tyr 
            20                  25                  30          


Pro Arg Leu Gly Gly Glu Gly Gly Lys Gly Gly Asp Val Trp Val Val 
        35                  40                  45              


Ala Gln Asn Arg Met Thr Leu Lys Gln Leu Lys Asp Arg Tyr Pro Arg 
    50                  55                  60                  


Lys Arg Phe Val Ala Gly Val Gly Ala Asn Ser Lys Ile Ser Ala Leu 
65                  70                  75                  80  


Lys Gly Ser Lys Gly Lys Asp Cys Glu Ile Pro Val Pro Val Gly Ile 
                85                  90                  95      


Ser Val Thr Asp Glu Asn Gly Lys Ile Ile Gly Glu Leu Asn Lys Glu 
            100                 105                 110         


Asn Asp Arg Ile Leu Val Ala Gln Gly Gly Leu Gly Gly Lys Leu Leu 
        115                 120                 125             


Thr Asn Phe Leu Pro Leu Lys Gly Gln Lys Arg Ile Ile His Leu Asp 
    130                 135                 140                 


Leu Lys Leu Ile Ala Asp Val Gly Leu Val Gly Phe Pro Asn Ala Gly 
145                 150                 155                 160 


Lys Ser Ser Leu Leu Ser Cys Val Ser His Ala Lys Pro Ala Ile Ala 
                165                 170                 175     


Asp Tyr Ala Phe Thr Thr Leu Lys Pro Glu Leu Gly Lys Ile Met Tyr 
            180                 185                 190         


Ser Asp Phe Lys Gln Ile Ser Val Ala Asp Leu Pro Gly Leu Ile Glu 
        195                 200                 205             


Gly Ala His Met Asn Lys Gly Met Gly His Lys Phe Leu Lys His Ile 
    210                 215                 220                 


Glu Arg Thr Arg Gln Leu Leu Phe Val Val Asp Ile Ser Gly Phe Gln 
225                 230                 235                 240 


Leu Ser Ser His Thr Gln Tyr Arg Thr Ala Phe Glu Thr Ile Ile Leu 
                245                 250                 255     


Leu Thr Lys Glu Leu Glu Leu Tyr Lys Glu Glu Leu Gln Thr Lys Pro 
            260                 265                 270         


Ala Leu Leu Ala Val Asn Lys Met Asp Leu Pro Asp Ala Gln Asp Lys 
        275                 280                 285             


Phe His Glu Leu Met Ser Gln Leu Gln Asn Pro Lys Asp Phe Leu His 
    290                 295                 300                 


Leu Phe Glu Lys Asn Met Ile Pro Glu Arg Thr Val Glu Phe Gln His 
305                 310                 315                 320 


Ile Ile Pro Ile Ser Ala Val Thr Gly Glu Gly Ile Glu Glu Leu Lys 
                325                 330                 335     


Asn Cys Ile Arg Lys Ser Leu Asp Glu Gln Ala Asn Gln Glu Asn Asp 
            340                 345                 350         


Ala Leu His Lys Lys Gln Leu Leu Asn Leu Trp Ile Ser Asp Thr Met 
        355                 360                 365             


Ser Ser Thr Glu Pro Pro Ser Lys His Ala Val Thr Thr Ser Lys Met 
    370                 375                 380                 


Asp Ile Ile 
385         


<210>  6319
<211>  243
<212>  PRT
<213>  Homo Sapiens

<400>  6319

Met Val His Cys Ser Cys Val Leu Phe Arg Lys Tyr Gly Asn Phe Ile 
1               5                   10                  15      


Asp Lys Leu Arg Leu Phe Thr Arg Gly Gly Ser Gly Gly Met Gly Tyr 
            20                  25                  30          


Pro Arg Leu Gly Gly Glu Gly Gly Lys Gly Gly Asp Val Trp Val Val 
        35                  40                  45              


Ala Gln Asn Arg Met Thr Leu Lys Gln Leu Lys Asp Arg Tyr Pro Arg 
    50                  55                  60                  


Lys Arg Phe Val Ala Gly Val Gly Ala Asn Ser Lys Ile Ser Ala Leu 
65                  70                  75                  80  


Lys Gly Ser Lys Gly Lys Asp Cys Glu Ile Pro Val Pro Val Gly Ile 
                85                  90                  95      


Ser Val Thr Asp Glu Asn Gly Lys Ile Ile Val Thr Thr Leu Lys Pro 
            100                 105                 110         


Glu Leu Gly Lys Ile Met Tyr Ser Asp Phe Lys Gln Ile Ser Val Ala 
        115                 120                 125             


Asp Leu Pro Gly Leu Ile Glu Gly Ala His Met Asn Lys Gly Met Gly 
    130                 135                 140                 


His Lys Phe Leu Lys His Ile Glu Arg Thr Arg Gln Leu Leu Phe Val 
145                 150                 155                 160 


Val Asp Ile Ser Gly Phe Gln Leu Ser Ser His Thr Gln Tyr Arg Thr 
                165                 170                 175     


Ala Phe Glu Thr Ile Ile Leu Leu Thr Lys Glu Leu Glu Leu Tyr Lys 
            180                 185                 190         


Glu Glu Leu Gln Thr Lys Pro Ala Leu Leu Ala Val Asn Lys Met Asp 
        195                 200                 205             


Leu Pro Asp Ala Gln Asp Lys Phe His Glu Leu Met Ser Gln Leu Gln 
    210                 215                 220                 


Asn Pro Lys Asp Phe Leu His Leu Phe Glu Lys Asn Met Ile Pro Glu 
225                 230                 235                 240 


Arg Thr Val 
            


<210>  6320
<211>  79
<212>  PRT
<213>  Homo Sapiens

<400>  6320

Met Val His Cys Ser Cys Val Leu Phe Arg Lys Tyr Gly Asn Phe Ile 
1               5                   10                  15      


Asp Lys Leu Arg Leu Phe Thr Arg Gly Gly Ser Gly Gly Met Gly Tyr 
            20                  25                  30          


Pro Arg Leu Gly Gly Glu Gly Gly Lys Gly Gly Asp Val Trp Val Val 
        35                  40                  45              


Ala Gln Asn Arg Met Thr Leu Lys Gln Leu Lys Asp Arg Tyr Pro Arg 
    50                  55                  60                  


Lys Arg Phe Val Ala Gly Val Gly Ala Asn Ser Lys Arg Thr Gln 
65                  70                  75                  


<210>  6321
<211>  115
<212>  PRT
<213>  Homo Sapiens

<400>  6321

Met Asn Ala Phe Leu Leu Ser Ala Leu Cys Leu Leu Gly Ala Trp Ala 
1               5                   10                  15      


Ala Leu Ala Gly Gly Val Thr Val Gln Asp Gly Asn Phe Ser Phe Ser 
            20                  25                  30          


Leu Glu Ser Val Lys Lys Leu Lys Asp Leu Gln Glu Pro Gln Glu Pro 
        35                  40                  45              


Arg Val Gly Lys Leu Arg Asn Phe Ala Pro Ile Pro Gly Glu Pro Val 
    50                  55                  60                  


Val Pro Ile Leu Cys Ser Asn Pro Asn Phe Pro Glu Glu Leu Lys Pro 
65                  70                  75                  80  


Leu Cys Lys Glu Pro Asn Ala Gln Glu Ile Leu Gln Arg Leu Glu Glu 
                85                  90                  95      


Ile Ala Glu Asp Pro Gly Thr Cys Glu Ile Cys Ala Tyr Ala Ala Cys 
            100                 105                 110         


Thr Gly Cys 
        115 


<210>  6322
<211>  112
<212>  PRT
<213>  Homo Sapiens

<400>  6322

Met Gly Cys Arg Ala Ala Ser Gly Leu Leu Pro Gly Val Ala Val Val 
1               5                   10                  15      


Leu Leu Leu Leu Leu Gln Ser Thr Gln Ser Val Tyr Ile Gln Tyr Gln 
            20                  25                  30          


Gly Phe Arg Val Gln Leu Glu Ser Met Lys Lys Leu Ser Asp Leu Glu 
        35                  40                  45              


Ala Gln Trp Ala Pro Ser Pro Arg Leu Gln Ala Gln Ser Leu Leu Pro 
    50                  55                  60                  


Ala Val Cys His His Pro Ala Leu Pro Gln Asp Leu Gln Pro Val Cys 
65                  70                  75                  80  


Ala Ser Gln Glu Ala Ser Ser Ile Phe Lys Thr Leu Arg Thr Ile Ala 
                85                  90                  95      


Asn Asp Asp Cys Glu Leu Cys Val Asn Val Ala Cys Thr Gly Cys Leu 
            100                 105                 110         


<210>  6323
<211>  134
<212>  PRT
<213>  Homo Sapiens

<400>  6323

Met Ala Arg Gly Ser Ala Val Ala Trp Ala Ala Leu Gly Pro Leu Leu 
1               5                   10                  15      


Trp Gly Cys Ala Leu Gly Leu Gln Gly Gly Met Leu Tyr Pro Gln Glu 
            20                  25                  30          


Ser Pro Ser Arg Glu Cys Lys Glu Leu Asp Gly Leu Trp Ser Phe Arg 
        35                  40                  45              


Ala Asp Phe Ser Asp Asn Arg Arg Arg Gly Phe Glu Glu Gln Trp Tyr 
    50                  55                  60                  


Arg Arg Pro Leu Trp Glu Ser Gly Pro Thr Val Asp Met Pro Val Pro 
65                  70                  75                  80  


Ser Ser Phe Asn Asp Ile Ser Gln Asp Trp Arg Leu Arg His Phe Val 
                85                  90                  95      


Gly Trp Val Trp Tyr Glu Arg Glu Val Ile Leu Pro Glu Arg Trp Thr 
            100                 105                 110         


Gln Asp Leu Arg Thr Arg Val Val Leu Arg Ile Gly Ser Ala His Ser 
        115                 120                 125             


Tyr Ala Ile Val Gly Trp 
    130                 


<210>  6324
<211>  144
<212>  PRT
<213>  Homo Sapiens

<400>  6324

Met Ala Arg Gly Ser Ala Val Ala Trp Ala Ala Leu Gly Pro Leu Leu 
1               5                   10                  15      


Trp Gly Cys Ala Leu Gly Leu Gln Gly Gly Met Leu Tyr Pro Gln Glu 
            20                  25                  30          


Ser Pro Ser Arg Glu Cys Lys Glu Leu Asp Gly Leu Trp Ser Phe Arg 
        35                  40                  45              


Ala Asp Phe Ser Asp Asn Arg Arg Arg Gly Phe Glu Glu Gln Trp Tyr 
    50                  55                  60                  


Arg Arg Pro Leu Trp Glu Ser Gly Pro Thr Val Asp Met Pro Val Pro 
65                  70                  75                  80  


Ser Ser Phe Asn Asp Ile Ser Gln Asp Trp Arg Leu Arg His Phe Val 
                85                  90                  95      


Gly Trp Val Trp Tyr Glu Arg Glu Val Ile Leu Pro Glu Arg Trp Thr 
            100                 105                 110         


Gln Asp Leu Arg Thr Arg Val Val Leu Arg Ile Gly Ser Ala His Ser 
        115                 120                 125             


Tyr Ala Ile Val Val Ser Gln Gly Leu Leu Cys Pro Glu His Ile Phe 
    130                 135                 140                 


<210>  6325
<211>  144
<212>  PRT
<213>  Homo Sapiens

<400>  6325

Met Ala Arg Gly Ser Ala Val Ala Trp Ala Ala Leu Gly Pro Leu Leu 
1               5                   10                  15      


Trp Gly Cys Ala Leu Gly Leu Gln Gly Gly Met Leu Tyr Pro Gln Glu 
            20                  25                  30          


Ser Pro Ser Arg Glu Cys Lys Glu Leu Asp Gly Leu Trp Ser Phe Arg 
        35                  40                  45              


Ala Asp Phe Ser Asp Asn Arg Arg Arg Gly Phe Glu Glu Gln Trp Tyr 
    50                  55                  60                  


Arg Arg Pro Leu Trp Glu Ser Gly Pro Thr Val Asp Met Pro Val Pro 
65                  70                  75                  80  


Ser Ser Phe Asn Asp Ile Ser Gln Asp Trp Arg Leu Arg His Phe Val 
                85                  90                  95      


Gly Trp Val Trp Tyr Glu Arg Glu Val Ile Leu Pro Glu Arg Trp Thr 
            100                 105                 110         


Gln Asp Leu Arg Thr Arg Val Val Leu Arg Ile Gly Ser Ala His Ser 
        115                 120                 125             


Tyr Ala Ile Val Val Ser Gln Gly Leu Leu Cys Pro Glu His Ile Phe 
    130                 135                 140                 


<210>  6326
<211>  651
<212>  PRT
<213>  Homo Sapiens

<400>  6326

Met Ala Arg Gly Ser Ala Val Ala Trp Ala Ala Leu Gly Pro Leu Leu 
1               5                   10                  15      


Trp Gly Cys Ala Leu Gly Leu Gln Gly Gly Met Leu Tyr Pro Gln Glu 
            20                  25                  30          


Ser Pro Ser Arg Glu Cys Lys Glu Leu Asp Gly Leu Trp Ser Phe Arg 
        35                  40                  45              


Ala Asp Phe Ser Asp Asn Arg Arg Arg Gly Phe Glu Glu Gln Trp Tyr 
    50                  55                  60                  


Arg Arg Pro Leu Trp Glu Ser Gly Pro Thr Val Asp Met Pro Val Pro 
65                  70                  75                  80  


Ser Ser Phe Asn Asp Ile Ser Gln Asp Trp Arg Leu Arg His Phe Val 
                85                  90                  95      


Gly Trp Val Trp Tyr Glu Arg Glu Val Ile Leu Pro Glu Arg Trp Thr 
            100                 105                 110         


Gln Asp Leu Arg Thr Arg Val Val Leu Arg Ile Gly Ser Ala His Ser 
        115                 120                 125             


Tyr Ala Ile Val Trp Val Asn Gly Val Asp Thr Leu Glu His Glu Gly 
    130                 135                 140                 


Gly Tyr Leu Pro Phe Glu Ala Asp Ile Ser Asn Leu Val Gln Val Gly 
145                 150                 155                 160 


Pro Leu Pro Ser Arg Leu Arg Ile Thr Ile Ala Ile Asn Asn Thr Leu 
                165                 170                 175     


Thr Pro Thr Thr Leu Pro Pro Gly Thr Ile Gln Tyr Leu Thr Asp Thr 
            180                 185                 190         


Ser Lys Tyr Pro Lys Gly Tyr Phe Val Gln Asn Thr Tyr Phe Asp Phe 
        195                 200                 205             


Phe Asn Tyr Ala Gly Leu Gln Arg Ser Val Leu Leu Tyr Thr Thr Pro 
    210                 215                 220                 


Thr Thr Tyr Ile Asp Asp Ile Thr Val Thr Thr Ser Val Glu Gln Asp 
225                 230                 235                 240 


Ser Gly Leu Val Asn Tyr Gln Ile Ser Val Lys Gly Ser Asn Leu Phe 
                245                 250                 255     


Lys Leu Glu Val Arg Leu Leu Asp Ala Glu Asn Lys Val Val Ala Asn 
            260                 265                 270         


Gly Thr Gly Thr Gln Gly Gln Leu Lys Val Pro Gly Val Ser Leu Trp 
        275                 280                 285             


Trp Pro Tyr Leu Met His Glu Arg Pro Ala Tyr Leu Tyr Ser Leu Glu 
    290                 295                 300                 


Val Gln Leu Thr Ala Gln Thr Ser Leu Gly Pro Val Ser Asp Phe Tyr 
305                 310                 315                 320 


Thr Leu Pro Val Gly Ile Arg Thr Val Ala Val Thr Lys Ser Gln Phe 
                325                 330                 335     


Leu Ile Asn Gly Lys Pro Phe Tyr Phe His Gly Val Asn Lys His Glu 
            340                 345                 350         


Asp Ala Asp Ile Arg Gly Lys Gly Phe Asp Trp Pro Leu Leu Val Lys 
        355                 360                 365             


Asp Phe Asn Leu Leu Arg Trp Leu Gly Ala Asn Ala Phe Arg Thr Ser 
    370                 375                 380                 


His Tyr Pro Tyr Ala Glu Glu Val Met Gln Met Cys Asp Arg Tyr Gly 
385                 390                 395                 400 


Ile Val Val Ile Asp Glu Cys Pro Gly Val Gly Leu Ala Leu Pro Gln 
                405                 410                 415     


Phe Phe Asn Asn Val Ser Leu His His His Met Gln Val Met Glu Glu 
            420                 425                 430         


Val Val Arg Arg Asp Lys Asn His Pro Ala Val Val Met Trp Ser Val 
        435                 440                 445             


Ala Asn Glu Pro Ala Ser His Leu Glu Ser Ala Gly Tyr Tyr Leu Lys 
    450                 455                 460                 


Met Val Ile Ala His Thr Lys Ser Leu Asp Pro Ser Arg Pro Val Thr 
465                 470                 475                 480 


Phe Val Ser Asn Ser Asn Tyr Ala Ala Asp Lys Gly Ala Pro Tyr Val 
                485                 490                 495     


Asp Val Ile Cys Leu Asn Ser Tyr Tyr Ser Trp Tyr His Asp Tyr Gly 
            500                 505                 510         


His Leu Glu Leu Ile Gln Leu Gln Leu Ala Thr Gln Phe Glu Asn Trp 
        515                 520                 525             


Tyr Lys Lys Tyr Gln Lys Pro Ile Ile Gln Ser Glu Tyr Gly Ala Glu 
    530                 535                 540                 


Thr Ile Ala Gly Phe His Gln Asp Pro Pro Leu Met Phe Thr Glu Glu 
545                 550                 555                 560 


Tyr Gln Lys Ser Leu Leu Glu Gln Tyr His Leu Gly Leu Asp Gln Lys 
                565                 570                 575     


Arg Arg Lys Tyr Val Val Gly Glu Leu Ile Trp Asn Phe Ala Asp Phe 
            580                 585                 590         


Met Thr Glu Gln Ser Pro Thr Arg Val Leu Gly Asn Lys Lys Gly Ile 
        595                 600                 605             


Phe Thr Arg Gln Arg Gln Pro Lys Ser Ala Ala Phe Leu Leu Arg Glu 
    610                 615                 620                 


Arg Tyr Trp Lys Ile Ala Asn Glu Thr Arg Tyr Pro His Ser Val Ala 
625                 630                 635                 640 


Lys Ser Gln Cys Leu Glu Asn Ser Leu Phe Thr 
                645                 650     


<210>  6327
<211>  505
<212>  PRT
<213>  Homo Sapiens

<400>  6327

Met Ala Arg Gly Ser Ala Val Ala Trp Ala Ala Leu Gly Pro Leu Leu 
1               5                   10                  15      


Trp Gly Cys Ala Leu Gly Leu Gln Gly Gly Met Leu Tyr Pro Gln Glu 
            20                  25                  30          


Ser Pro Ser Arg Glu Cys Lys Glu Leu Asp Gly Leu Trp Ser Phe Arg 
        35                  40                  45              


Ala Asp Phe Ser Asp Asn Arg Arg Arg Gly Phe Glu Glu Gln Trp Tyr 
    50                  55                  60                  


Arg Arg Pro Leu Trp Glu Ser Gly Pro Thr Val Asp Met Pro Val Pro 
65                  70                  75                  80  


Ser Ser Phe Asn Asp Ile Ser Gln Asp Trp Arg Leu Arg His Phe Val 
                85                  90                  95      


Gly Trp Val Trp Tyr Glu Arg Glu Val Ile Leu Pro Glu Arg Trp Thr 
            100                 105                 110         


Gln Asp Leu Arg Thr Arg Val Val Leu Arg Ile Gly Ser Ala His Ser 
        115                 120                 125             


Tyr Ala Ile Val Trp Val Asn Gly Val Asp Thr Leu Glu His Glu Gly 
    130                 135                 140                 


Gly Tyr Leu Pro Phe Glu Ala Asp Ile Ser Asn Leu Val Gln Val Gln 
145                 150                 155                 160 


Leu Thr Ala Gln Thr Ser Leu Gly Pro Val Ser Asp Phe Tyr Thr Leu 
                165                 170                 175     


Pro Val Gly Ile Arg Thr Val Ala Val Thr Lys Ser Gln Phe Leu Ile 
            180                 185                 190         


Asn Gly Lys Pro Phe Tyr Phe His Gly Val Asn Lys His Glu Asp Ala 
        195                 200                 205             


Asp Ile Arg Gly Lys Gly Phe Asp Trp Pro Leu Leu Val Lys Asp Phe 
    210                 215                 220                 


Asn Leu Leu Arg Trp Leu Gly Ala Asn Ala Phe Arg Thr Ser His Tyr 
225                 230                 235                 240 


Pro Tyr Ala Glu Glu Val Met Gln Met Cys Asp Arg Tyr Gly Ile Val 
                245                 250                 255     


Val Ile Asp Glu Cys Pro Gly Val Gly Leu Ala Leu Pro Gln Phe Phe 
            260                 265                 270         


Asn Asn Val Ser Leu His His His Met Gln Val Met Glu Glu Val Val 
        275                 280                 285             


Arg Arg Asp Lys Asn His Pro Ala Val Val Met Trp Ser Val Ala Asn 
    290                 295                 300                 


Glu Pro Ala Ser His Leu Glu Ser Ala Gly Tyr Tyr Leu Lys Met Val 
305                 310                 315                 320 


Ile Ala His Thr Lys Ser Leu Asp Pro Ser Arg Pro Val Thr Phe Val 
                325                 330                 335     


Ser Asn Ser Asn Tyr Ala Ala Asp Lys Gly Ala Pro Tyr Val Asp Val 
            340                 345                 350         


Ile Cys Leu Asn Ser Tyr Tyr Ser Trp Tyr His Asp Tyr Gly His Leu 
        355                 360                 365             


Glu Leu Ile Gln Leu Gln Leu Ala Thr Gln Phe Glu Asn Trp Tyr Lys 
    370                 375                 380                 


Lys Tyr Gln Lys Pro Ile Ile Gln Ser Glu Tyr Gly Ala Glu Thr Ile 
385                 390                 395                 400 


Ala Gly Phe His Gln Asp Pro Pro Leu Met Phe Thr Glu Glu Tyr Gln 
                405                 410                 415     


Lys Ser Leu Leu Glu Gln Tyr His Leu Gly Leu Asp Gln Lys Arg Arg 
            420                 425                 430         


Lys Tyr Val Val Gly Glu Leu Ile Trp Asn Phe Ala Asp Phe Met Thr 
        435                 440                 445             


Glu Gln Ser Pro Thr Arg Val Leu Gly Asn Lys Lys Gly Ile Phe Thr 
    450                 455                 460                 


Arg Gln Arg Gln Pro Lys Ser Ala Ala Phe Leu Leu Arg Glu Arg Tyr 
465                 470                 475                 480 


Trp Lys Ile Ala Asn Glu Thr Arg Tyr Pro His Ser Val Ala Lys Ser 
                485                 490                 495     


Gln Cys Leu Glu Asn Ser Leu Phe Thr 
            500                 505 


<210>  6328
<211>  195
<212>  PRT
<213>  Homo Sapiens

<400>  6328

Met Pro Asn Phe Leu Gly Leu His Arg Ala Arg Ser Phe Thr Val Leu 
1               5                   10                  15      


Cys Phe Trp Ser Thr Ala Asp Val Leu Asn Ala Ser Gly Pro Arg Arg 
            20                  25                  30          


Gln Trp His Pro Leu Ala Ser Cys Ser Ser Trp Ser Arg Pro Gln Ser 
        35                  40                  45              


Gln Gly Ser Thr Pro Gly Val Leu Cys Lys Thr Gly Met Gly Arg Glu 
    50                  55                  60                  


Pro Ile Pro Glu Thr Gln Cys His Phe Ala Asn Ser Met Cys Ser Leu 
65                  70                  75                  80  


His Val Ser Val Pro Tyr Phe Gly Asn Ser Pro Asn Ile Ser Asn Phe 
                85                  90                  95      


Phe Arg Trp Ser Leu Ala Leu Ser Pro Arg Gln Trp Cys Asp Leu Gly 
            100                 105                 110         


Ser Leu Gln Pro Pro Ser Pro Arg Phe Lys Gly Phe Ser Cys Leu Ser 
        115                 120                 125             


Leu Pro Ser Ser Trp Asp Tyr Arg Arg Ala Pro Ser Pro Ala Asn Phe 
    130                 135                 140                 


Cys Ile Leu Val Glu Met Gly Phe His His Val Gly Gln Ala Asp Leu 
145                 150                 155                 160 


Glu Leu Leu Thr Ser Ala Asp Leu Pro Thr Ser Ala Ser Gln Ser Ala 
                165                 170                 175     


Gly Ile Thr Gly Val Ser His His Ala Trp Pro Gln Thr Leu Ser Leu 
            180                 185                 190         


Leu Leu Tyr 
        195 


<210>  6329
<211>  440
<212>  PRT
<213>  Homo Sapiens

<400>  6329

Met Arg Arg Tyr Leu Arg Val Val Val Leu Cys Val Ala Cys Gly Phe 
1               5                   10                  15      


Cys Ser Leu Leu Tyr Ala Phe Ser Gln Leu Ala Val Ser Leu Glu Glu 
            20                  25                  30          


Gly Thr Gly Gly Gly Gly Gly Lys Pro Gln Ala Ala Val Ala Ser Trp 
        35                  40                  45              


Leu Ala Gly Gly Gly Arg Gly Ala Val Arg Gly Ala Gly Val Ala Gly 
    50                  55                  60                  


Pro Ala Ala His Pro Gly Val Ser Asp Arg Cys Lys Asp Phe Ser Leu 
65                  70                  75                  80  


Cys Tyr Trp Asn Pro Tyr Trp Met Leu Pro Ser Asp Val Cys Gly Met 
                85                  90                  95      


Asn Cys Phe Trp Glu Ala Ala Phe Arg Tyr Ser Leu Lys Ile Gln Pro 
            100                 105                 110         


Val Glu Lys Met His Leu Ala Val Val Ala Cys Gly Glu Arg Leu Glu 
        115                 120                 125             


Glu Thr Met Thr Met Leu Lys Ser Ala Ile Ile Phe Ser Ile Lys Pro 
    130                 135                 140                 


Leu Gln Phe His Ile Phe Ala Glu Asp Gln Leu His His Ser Phe Lys 
145                 150                 155                 160 


Gly Arg Leu Asp Asn Trp Ser Phe Leu Gln Thr Phe Asn Tyr Thr Leu 
                165                 170                 175     


Tyr Pro Ile Thr Phe Pro Ser Glu Asn Ala Ala Glu Trp Lys Lys Leu 
            180                 185                 190         


Phe Lys Pro Cys Ala Ser Gln Arg Leu Phe Leu Pro Leu Ile Leu Lys 
        195                 200                 205             


Glu Val Asp Ser Leu Leu Tyr Val Asp Thr Asp Ile Leu Phe Leu Arg 
    210                 215                 220                 


Pro Val Asp Asp Ile Trp Ser Leu Leu Lys Lys Phe Asn Ser Thr Gln 
225                 230                 235                 240 


Ile Ala Ala Met Ala Pro Glu His Glu Glu Pro Arg Ile Gly Trp Tyr 
                245                 250                 255     


Asn Arg Phe Ala Arg His Pro Tyr Tyr Gly Lys Thr Gly Val Asn Ser 
            260                 265                 270         


Gly Val Met Leu Met Asn Met Thr Arg Met Arg Arg Lys Tyr Phe Lys 
        275                 280                 285             


Asn Asp Met Thr Thr Val Arg Leu Gln Trp Gly Asp Ile Leu Met Pro 
    290                 295                 300                 


Leu Leu Lys Lys Tyr Lys Leu Asn Ile Thr Trp Gly Asp Gln Asp Leu 
305                 310                 315                 320 


Leu Asn Ile Val Phe Phe His Asn Pro Glu Ser Leu Phe Val Phe Pro 
                325                 330                 335     


Cys Gln Trp Asn Tyr Arg Pro Asp His Cys Ile Tyr Gly Ser Asn Cys 
            340                 345                 350         


Gln Glu Ala Glu Glu Gly Gly Ile Phe Ile Leu His Gly Asn Arg Gly 
        355                 360                 365             


Val Tyr His Asp Asp Lys Gln Pro Ala Phe Arg Ala Val Tyr Glu Ala 
    370                 375                 380                 


Leu Arg Asn Cys Ser Phe Glu Asp Asp Asn Ile Arg Ser Leu Leu Lys 
385                 390                 395                 400 


Pro Leu Glu Leu Glu Leu Gln Lys Thr Val His Thr Tyr Cys Gly Lys 
                405                 410                 415     


Ile Tyr Lys Ile Phe Ile Lys Gln Leu Ala Lys Ser Val Arg Asp Arg 
            420                 425                 430         


Tyr Ala Arg Ser Pro Lys Glu Lys 
        435                 440 


<210>  6330
<211>  409
<212>  PRT
<213>  Homo Sapiens

<400>  6330

Met Arg Arg Tyr Leu Arg Val Val Val Leu Cys Val Ala Cys Gly Phe 
1               5                   10                  15      


Cys Ser Leu Leu Tyr Ala Phe Ser Gln Leu Ala Val Ser Leu Glu Glu 
            20                  25                  30          


Gly Thr Gly Gly Gly Gly Gly Lys Pro Gln Ala Ala Val Ala Ser Trp 
        35                  40                  45              


Leu Ala Gly Gly Gly Arg Gly Ala Val Arg Gly Ala Gly Val Ala Gly 
    50                  55                  60                  


Pro Ala Ala His Pro Gly Val Ser Asp Arg Tyr Ser Leu Lys Ile Gln 
65                  70                  75                  80  


Pro Val Glu Lys Met His Leu Ala Val Val Ala Cys Gly Glu Arg Leu 
                85                  90                  95      


Glu Glu Thr Met Thr Met Leu Lys Ser Ala Ile Ile Phe Ser Ile Lys 
            100                 105                 110         


Pro Leu Gln Phe His Ile Phe Ala Glu Asp Gln Leu His His Ser Phe 
        115                 120                 125             


Lys Gly Arg Leu Asp Asn Trp Ser Phe Leu Gln Thr Phe Asn Tyr Thr 
    130                 135                 140                 


Leu Tyr Pro Ile Thr Phe Pro Ser Glu Asn Ala Ala Glu Trp Lys Lys 
145                 150                 155                 160 


Leu Phe Lys Pro Cys Ala Ser Gln Arg Leu Phe Leu Pro Leu Ile Leu 
                165                 170                 175     


Lys Glu Val Asp Ser Leu Leu Tyr Val Asp Thr Asp Ile Leu Phe Leu 
            180                 185                 190         


Arg Pro Val Asp Asp Ile Trp Ser Leu Leu Lys Lys Phe Asn Ser Thr 
        195                 200                 205             


Gln Ile Ala Ala Met Ala Pro Glu His Glu Glu Pro Arg Ile Gly Trp 
    210                 215                 220                 


Tyr Asn Arg Phe Ala Arg His Pro Tyr Tyr Gly Lys Thr Gly Val Asn 
225                 230                 235                 240 


Ser Gly Val Met Leu Met Asn Met Thr Arg Met Arg Arg Lys Tyr Phe 
                245                 250                 255     


Lys Asn Asp Met Thr Thr Val Arg Leu Gln Trp Gly Asp Ile Leu Met 
            260                 265                 270         


Pro Leu Leu Lys Lys Tyr Lys Leu Asn Ile Thr Trp Gly Asp Gln Asp 
        275                 280                 285             


Leu Leu Asn Ile Val Phe Phe His Asn Pro Glu Ser Leu Phe Val Phe 
    290                 295                 300                 


Pro Cys Gln Trp Asn Tyr Arg Pro Asp His Cys Ile Tyr Gly Ser Asn 
305                 310                 315                 320 


Cys Gln Glu Ala Glu Glu Gly Gly Ile Phe Ile Leu His Gly Asn Arg 
                325                 330                 335     


Gly Val Tyr His Asp Asp Lys Gln Pro Ala Phe Arg Ala Val Tyr Glu 
            340                 345                 350         


Ala Leu Arg Asn Cys Ser Phe Glu Asp Asp Asn Ile Arg Ser Leu Leu 
        355                 360                 365             


Lys Pro Leu Glu Leu Glu Leu Gln Lys Thr Val His Thr Tyr Cys Gly 
    370                 375                 380                 


Lys Ile Tyr Lys Ile Phe Ile Lys Gln Leu Ala Lys Ser Val Arg Asp 
385                 390                 395                 400 


Arg Tyr Ala Arg Ser Pro Lys Glu Lys 
                405                 


<210>  6331
<211>  164
<212>  PRT
<213>  Homo Sapiens

<400>  6331

Met Ala Pro Glu His Glu Ile Pro Lys Ile Gly Trp Tyr Ser Arg Phe 
1               5                   10                  15      


Ala Arg His Pro Phe Tyr Gly Ser Ala Gly Val Asn Ser Gly Val Met 
            20                  25                  30          


Leu Met Asn Leu Thr Arg Ile Arg Ser Thr Gln Phe Lys Asn Ser Met 
        35                  40                  45              


Ile Pro Thr Gly Leu Ala Trp Glu Asp Met Leu Tyr Pro Leu Tyr Gln 
    50                  55                  60                  


Lys Tyr Lys Asn Ala Ile Thr Trp Gly Asp Gln Asp Leu Leu Asn Ile 
65                  70                  75                  80  


Ile Phe Tyr Phe Asn Pro Glu Cys Leu Tyr Val Phe Pro Cys Gln Trp 
                85                  90                  95      


Asn Tyr Arg Pro Asp His Cys Met Tyr Gly Ser Asn Cys Arg Glu Ala 
            100                 105                 110         


Glu His Glu Gly Val Ser Val Leu His Gly Asn Arg Gly Val Tyr His 
        115                 120                 125             


Asp Asp Lys Gln Pro Thr Phe Arg Ala Leu Tyr Glu Ala Ile Arg Asp 
    130                 135                 140                 


Ile Leu Arg Arg Gly Gly Lys Arg Lys Phe Val Leu Ser Trp Ile Ser 
145                 150                 155                 160 


Phe Phe Val Met 
                


<210>  6332
<211>  443
<212>  PRT
<213>  Homo Sapiens

<400>  6332

Met Lys Leu Arg Ser Lys Ala Ala Ala Leu Leu Leu Leu Ala Leu Ala 
1               5                   10                  15      


Ala Leu Leu Leu Ala Leu Leu Ser Leu Arg Ala Gly Arg Ala Glu Pro 
            20                  25                  30          


Pro Ala Leu Pro Ala Arg Pro Ala Ser Ala Pro Gln Arg His Pro Ala 
        35                  40                  45              


Pro Val Pro Ala Arg Trp Pro Gly Pro Gly Ala Leu Pro Gly Ala Ser 
    50                  55                  60                  


Pro Gly Val Arg Arg Arg Arg Pro Pro Arg Pro Arg Pro Arg Ala Gly 
65                  70                  75                  80  


Arg Arg Gly Ala Ala Arg Leu Glu Lys Leu Ala Arg Arg Pro Gly Glu 
                85                  90                  95      


Pro Arg Ser Phe Gln Ala Val Leu Pro Pro Glu Leu Trp Ile His Leu 
            100                 105                 110         


Ala Val Val Ala Cys Gly Asn Arg Leu Glu Glu Thr Leu Val Met Leu 
        115                 120                 125             


Lys Ser Ala Val Leu Phe Ser His Arg Lys Ile Gln Phe His Ile Phe 
    130                 135                 140                 


Thr Glu Asp Ser Leu Lys Pro Glu Phe Asp Lys Gln Leu Arg Gln Trp 
145                 150                 155                 160 


Pro Asp Ser Tyr Thr Lys Lys Phe Glu His Arg Ile Tyr Pro Ile Thr 
                165                 170                 175     


Phe Ser Val Gly Asn Pro Gln Glu Trp Lys Lys Leu Phe Lys Pro Cys 
            180                 185                 190         


Ala Ala Gln Arg Leu Phe Leu Pro Val Ile Leu Lys Asp Val Asp Ser 
        195                 200                 205             


Leu Leu Tyr Val Asp Thr Asp Val Leu Phe Leu Arg Pro Val Asp Asp 
    210                 215                 220                 


Ile Trp Lys Leu Leu Arg Leu Phe Asn Ser Thr Gln Leu Ala Ala Met 
225                 230                 235                 240 


Ala Pro Glu His Glu Ile Pro Lys Ile Gly Trp Tyr Ser Arg Phe Ala 
                245                 250                 255     


Arg His Pro Phe Tyr Gly Ser Ala Gly Val Asn Ser Gly Val Met Leu 
            260                 265                 270         


Met Asn Leu Thr Arg Ile Arg Ser Thr Gln Phe Lys Asn Ser Met Ile 
        275                 280                 285             


Pro Thr Gly Leu Ala Trp Glu Asp Met Leu Tyr Pro Leu Tyr Gln Lys 
    290                 295                 300                 


Tyr Lys Asn Ala Ile Thr Trp Gly Asp Gln Asp Leu Leu Asn Ile Ile 
305                 310                 315                 320 


Phe Tyr Phe Asn Pro Glu Cys Leu Tyr Val Phe Pro Cys Gln Trp Asn 
                325                 330                 335     


Tyr Arg Pro Asp His Cys Met Tyr Gly Ser Asn Cys Arg Glu Ala Glu 
            340                 345                 350         


His Glu Gly Val Ser Val Leu His Gly Asn Arg Gly Val Tyr His Asp 
        355                 360                 365             


Asp Lys Gln Pro Thr Phe Arg Ala Leu Tyr Glu Ala Ile Arg Asp Phe 
    370                 375                 380                 


Pro Phe Gln Asp Asn Leu Phe Gln Ser Met Tyr Tyr Pro Leu Gln Leu 
385                 390                 395                 400 


Lys Phe Leu Glu Thr Val His Thr Leu Cys Gly Arg Ile Pro Gln Val 
                405                 410                 415     


Phe Leu Lys Gln Ile Glu Lys Thr Met Lys Arg Ala Tyr Glu Lys His 
            420                 425                 430         


Val Ile Ile His Val Gly Pro Asn Gln Met His 
        435                 440             


<210>  6333
<211>  102
<212>  PRT
<213>  Homo Sapiens

<400>  6333

Met Leu Lys Ser Ala Val Leu Phe Ser His Arg Lys Ile Gln Phe His 
1               5                   10                  15      


Ile Phe Thr Glu Asp Ser Leu Lys Pro Glu Phe Asp Lys Gln Leu Arg 
            20                  25                  30          


Gln Trp Pro Asp Ser Tyr Thr Lys Lys Phe Glu His Arg Ile Tyr Pro 
        35                  40                  45              


Ile Thr Phe Ser Val Gly Asn Pro Gln Glu Trp Lys Lys Leu Phe Lys 
    50                  55                  60                  


Pro Cys Ala Ala Gln Arg Leu Phe Leu Pro Val Ile Leu Lys Asp Val 
65                  70                  75                  80  


Asp Ser Leu Leu Tyr Val Asp Thr Asp Val Leu Phe Leu Arg Pro Val 
                85                  90                  95      


Asp Asp Ile Trp Lys Leu 
            100         


<210>  6334
<211>  65
<212>  PRT
<213>  Homo Sapiens

<400>  6334

Met His Thr Ser Thr Ser Ser Ser Val Thr Lys Ser Tyr Ile Ser Ser 
1               5                   10                  15      


Gln Thr Asn Gly Glu Thr Gly Gln Leu Val His Arg Phe Thr Val Pro 
            20                  25                  30          


Ala Pro Val Val Ile Ile Leu Ile Ile Leu Cys Val Met Ala Gly Ile 
        35                  40                  45              


Ile Gly Thr Ile Leu Leu Ile Ser Tyr Ser Ile Arg Arg Leu Ile Lys 
    50                  55                  60                  


Ala 
65  


<210>  6335
<211>  121
<212>  PRT
<213>  Homo Sapiens

<400>  6335

Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Glu Ile Val Ser 
1               5                   10                  15      


Ile Ser Ala Leu Ser Thr Thr Glu Val Ala Met His Thr Ser Thr Ser 
            20                  25                  30          


Ser Ser Val Thr Lys Ser Tyr Ile Ser Ser Gln Thr Asn Asp Lys His 
        35                  40                  45              


Lys Arg Asp Thr Cys Pro Ala His Thr Ala Asn Glu Val Ser Glu Ile 
    50                  55                  60                  


Ser Val Thr Thr Val Ser Pro Pro Glu Lys Lys Asn Gly Glu Thr Gly 
65                  70                  75                  80  


Gln Leu Val His Arg Phe Thr Val Pro Ala Pro Val Val Ile Ile Leu 
                85                  90                  95      


Ile Ile Leu Cys Val Met Ala Gly Ile Ile Gly Thr Ile Leu Leu Ile 
            100                 105                 110         


Ser Tyr Ser Ile Arg Arg Leu Ile Lys 
        115                 120     


<210>  6336
<211>  91
<212>  PRT
<213>  Homo Sapiens

<400>  6336

Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Glu Ile Val Ser 
1               5                   10                  15      


Ile Ser Ala Leu Ser Thr Thr Glu Val Ala Met His Thr Ser Thr Ser 
            20                  25                  30          


Ser Ser Val Thr Lys Ser Tyr Ile Ser Ser Gln Thr Asn Gly Glu Thr 
        35                  40                  45              


Gly Gln Leu Val His Arg Phe Thr Val Pro Ala Pro Val Val Ile Ile 
    50                  55                  60                  


Leu Ile Ile Leu Cys Val Met Ala Gly Ile Ile Gly Thr Ile Leu Leu 
65                  70                  75                  80  


Ile Ser Tyr Ser Ile Arg Arg Leu Ile Lys Ala 
                85                  90      


<210>  6337
<211>  62
<212>  PRT
<213>  Homo Sapiens

<400>  6337

Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Glu Ile Val Ser 
1               5                   10                  15      


Ile Ser Ala Leu Ser Thr Thr Glu Val Ala Met His Thr Ser Thr Ser 
            20                  25                  30          


Ser Ser Val Thr Lys Ser Tyr Ile Ser Ser Gln Thr Asn Gly Glu Thr 
        35                  40                  45              


Gly Gln Leu Val His Arg Phe Thr Val Pro Val Phe Ala Asp 
    50                  55                  60          


<210>  6338
<211>  42
<212>  PRT
<213>  Homo Sapiens

<400>  6338

Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Gly Asp Gly Ala 
1               5                   10                  15      


Asn Pro Glu Asn Ser Gly Arg Arg Gly Gln Lys Ala Glu Gly Arg Ala 
            20                  25                  30          


Arg Ala Lys Ile Leu Lys Gln Glu Lys Leu 
        35                  40          


<210>  6339
<211>  58
<212>  PRT
<213>  Homo Sapiens

<400>  6339

Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Gly Glu Thr Gly 
1               5                   10                  15      


Gln Leu Val His Arg Phe Thr Val Pro Ala Pro Val Val Ile Ile Leu 
            20                  25                  30          


Ile Ile Leu Cys Val Met Ala Gly Ile Ile Gly Thr Ile Leu Leu Ile 
        35                  40                  45              


Ser Tyr Ser Ile Arg Arg Leu Ile Lys Ala 
    50                  55              


<210>  6340
<211>  45
<212>  PRT
<213>  Homo Sapiens

<400>  6340

Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Gly Asn Phe Glu 
1               5                   10                  15      


His Ser Ala Glu Gly Pro Ser Trp Leu Pro Leu Arg Arg Ser Pro Ser 
            20                  25                  30          


Thr Ser Thr Pro Leu His Leu Gly Ala Ile Pro Leu Ile 
        35                  40                  45  


<210>  6341
<211>  45
<212>  PRT
<213>  Homo Sapiens

<400>  6341

Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Gly Asn Phe Glu 
1               5                   10                  15      


His Ser Ala Glu Gly Pro Ser Trp Leu Pro Leu Arg Arg Ser Pro Ser 
            20                  25                  30          


Thr Ser Thr Pro Leu His Leu Gly Ala Ile Pro Leu Ile 
        35                  40                  45  


<210>  6342
<211>  45
<212>  PRT
<213>  Homo Sapiens

<400>  6342

Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Gly Asn Phe Glu 
1               5                   10                  15      


His Ser Ala Glu Gly Pro Ser Trp Leu Pro Leu Arg Arg Ser Pro Ser 
            20                  25                  30          


Thr Ser Thr Pro Leu His Leu Gly Ala Ile Pro Leu Ile 
        35                  40                  45  


<210>  6343
<211>  262
<212>  PRT
<213>  Homo Sapiens

<400>  6343

Met Arg Asn Ser Tyr Arg Phe Leu Ala Ser Ser Leu Ser Val Val Val 
1               5                   10                  15      


Ser Leu Leu Leu Ile Pro Glu Asp Val Cys Glu Lys Ile Ile Gly Gly 
            20                  25                  30          


Asn Glu Val Thr Pro His Ser Arg Pro Tyr Met Val Leu Leu Ser Leu 
        35                  40                  45              


Asp Arg Lys Thr Ile Cys Ala Gly Ala Leu Ile Ala Lys Asp Trp Val 
    50                  55                  60                  


Leu Thr Ala Ala His Cys Asn Leu Asn Lys Arg Ser Gln Val Ile Leu 
65                  70                  75                  80  


Gly Ala His Ser Ile Thr Arg Glu Glu Pro Thr Lys Gln Ile Met Leu 
                85                  90                  95      


Val Lys Lys Glu Phe Pro Tyr Pro Cys Tyr Asp Pro Ala Thr Arg Glu 
            100                 105                 110         


Gly Asp Leu Lys Leu Leu Gln Leu Met Glu Lys Ala Lys Ile Asn Lys 
        115                 120                 125             


Tyr Val Thr Ile Leu His Leu Pro Lys Lys Gly Asp Asp Val Lys Pro 
    130                 135                 140                 


Gly Thr Met Cys Gln Val Ala Gly Trp Gly Arg Thr His Asn Ser Ala 
145                 150                 155                 160 


Ser Trp Ser Asp Thr Leu Arg Glu Val Asn Ile Thr Ile Ile Asp Arg 
                165                 170                 175     


Lys Val Cys Asn Asp Arg Asn His Tyr Asn Phe Asn Pro Val Ile Gly 
            180                 185                 190         


Met Asn Met Val Cys Ala Gly Ser Leu Arg Gly Gly Arg Asp Ser Cys 
        195                 200                 205             


Asn Gly Asp Ser Gly Ser Pro Leu Leu Cys Glu Gly Val Phe Arg Gly 
    210                 215                 220                 


Val Thr Ser Phe Gly Leu Glu Asn Lys Cys Gly Asp Pro Arg Gly Pro 
225                 230                 235                 240 


Gly Val Tyr Ile Leu Leu Ser Lys Lys His Leu Asn Trp Ile Ile Met 
                245                 250                 255     


Thr Ile Lys Gly Ala Val 
            260         


<210>  6344
<211>  44
<212>  PRT
<213>  Homo Sapiens

<400>  6344

Met Gln Glu Cys Ser Glu Leu Gln Leu Pro Phe Tyr Gln Asp Pro Pro 
1               5                   10                  15      


Ser Val Met Leu Asp Lys Leu Ser Ala Gly Met Ala Glu Gln Gln Ala 
            20                  25                  30          


Ile Leu Lys Lys Ser Gln Gly Asp His Arg Gly Thr 
        35                  40                  


<210>  6345
<211>  35
<212>  PRT
<213>  Homo Sapiens

<400>  6345

Met Gln Pro Ile Leu Leu Leu Leu Ala Phe Leu Leu Leu Pro Arg Ala 
1               5                   10                  15      


Asp Ala Ala Gly Glu Lys Gly Gln Ala Asp Gln Ser Cys Ala Ala Pro 
            20                  25                  30          


Gln Ala Thr 
        35  


<210>  6346
<211>  202
<212>  PRT
<213>  Homo Sapiens

<400>  6346

Met Gln Pro Ile Leu Leu Leu Leu Ala Phe Leu Leu Leu Pro Arg Ala 
1               5                   10                  15      


Asp Ala Gly Glu Ile Ile Gly Gly His Glu Ala Lys Pro His Ser Arg 
            20                  25                  30          


Pro Tyr Met Ala Tyr Leu Met Ile Trp Asp Gln Lys Ser Leu Lys Arg 
        35                  40                  45              


Cys Gly Gly Phe Leu Ile Arg Asp Asp Phe Val Leu Thr Ala Ala His 
    50                  55                  60                  


Cys Trp Gly Arg Leu Glu Arg Lys Ala Lys Arg Thr Arg Ala Val Gln 
65                  70                  75                  80  


Pro Leu Arg Leu Pro Ser Asn Lys Ala Gln Val Lys Pro Gly Gln Thr 
                85                  90                  95      


Cys Ser Val Ala Gly Trp Gly Gln Thr Ala Pro Leu Gly Lys His Ser 
            100                 105                 110         


His Thr Leu Gln Glu Val Lys Met Thr Val Gln Glu Asp Arg Lys Cys 
        115                 120                 125             


Glu Ser Asp Leu Arg His Tyr Tyr Asp Ser Thr Ile Glu Leu Cys Val 
    130                 135                 140                 


Gly Asp Pro Glu Ile Lys Lys Thr Ser Phe Lys Gly Asp Ser Gly Gly 
145                 150                 155                 160 


Pro Leu Val Cys Asn Lys Val Ala Gln Gly Ile Val Ser Tyr Gly Arg 
                165                 170                 175     


Asn Asn Gly Met Pro Pro Arg Ala Cys Thr Lys Val Ser Ser Phe Val 
            180                 185                 190         


His Trp Ile Lys Lys Thr Met Lys Arg Tyr 
        195                 200         


<210>  6347
<211>  202
<212>  PRT
<213>  Homo Sapiens

<400>  6347

Met Gln Pro Ile Leu Leu Leu Leu Ala Phe Leu Leu Leu Pro Arg Ala 
1               5                   10                  15      


Asp Ala Gly Glu Ile Ile Gly Gly His Glu Ala Lys Pro His Ser Arg 
            20                  25                  30          


Pro Tyr Met Ala Tyr Leu Met Ile Trp Asp Gln Lys Ser Leu Lys Arg 
        35                  40                  45              


Cys Gly Gly Phe Leu Ile Arg Asp Asp Phe Val Leu Thr Ala Ala His 
    50                  55                  60                  


Cys Trp Gly Arg Leu Glu Arg Lys Ala Lys Arg Thr Arg Ala Val Gln 
65                  70                  75                  80  


Pro Leu Arg Leu Pro Ser Asn Lys Ala Gln Val Lys Pro Gly Gln Thr 
                85                  90                  95      


Cys Ser Val Ala Gly Trp Gly Gln Thr Ala Pro Leu Gly Lys His Ser 
            100                 105                 110         


His Thr Leu Gln Glu Val Lys Met Thr Val Gln Glu Asp Arg Lys Cys 
        115                 120                 125             


Glu Ser Asp Leu Arg His Tyr Tyr Asp Ser Thr Ile Glu Leu Cys Val 
    130                 135                 140                 


Gly Asp Pro Glu Ile Lys Lys Thr Ser Phe Lys Gly Asp Ser Gly Gly 
145                 150                 155                 160 


Pro Leu Val Cys Asn Lys Val Ala Gln Gly Ile Val Ser Tyr Gly Arg 
                165                 170                 175     


Asn Asn Gly Met Pro Pro Arg Ala Cys Thr Lys Val Ser Ser Phe Val 
            180                 185                 190         


His Trp Ile Lys Lys Thr Met Lys Arg Tyr 
        195                 200         


<210>  6348
<211>  247
<212>  PRT
<213>  Homo Sapiens

<400>  6348

Met Gln Pro Ile Leu Leu Leu Leu Ala Phe Leu Leu Leu Pro Arg Ala 
1               5                   10                  15      


Asp Ala Gly Glu Ile Ile Gly Gly His Glu Ala Lys Pro His Ser Arg 
            20                  25                  30          


Pro Tyr Met Ala Tyr Leu Met Ile Trp Asp Gln Lys Ser Leu Lys Arg 
        35                  40                  45              


Cys Gly Gly Phe Leu Ile Arg Asp Asp Phe Val Leu Thr Ala Ala His 
    50                  55                  60                  


Cys Trp Gly Ser Ser Ile Asn Val Thr Leu Gly Ala His Asn Ile Lys 
65                  70                  75                  80  


Glu Gln Glu Pro Thr Gln Gln Phe Ile Pro Val Lys Arg Pro Ile Pro 
                85                  90                  95      


His Pro Ala Tyr Asn Pro Lys Asn Phe Ser Asn Asp Ile Met Leu Leu 
            100                 105                 110         


Gln Leu Glu Arg Lys Ala Lys Arg Thr Arg Ala Val Gln Pro Leu Arg 
        115                 120                 125             


Leu Pro Ser Asn Lys Ala Gln Val Lys Pro Gly Gln Thr Cys Ser Val 
    130                 135                 140                 


Ala Gly Trp Gly Gln Thr Ala Pro Leu Gly Lys His Ser His Thr Leu 
145                 150                 155                 160 


Gln Glu Val Lys Met Thr Val Gln Glu Asp Arg Lys Cys Glu Ser Asp 
                165                 170                 175     


Leu Arg His Tyr Tyr Asp Ser Thr Ile Glu Leu Cys Val Gly Asp Pro 
            180                 185                 190         


Glu Ile Lys Lys Thr Ser Phe Lys Gly Asp Ser Gly Gly Pro Leu Val 
        195                 200                 205             


Cys Asn Lys Val Ala Gln Gly Ile Val Ser Tyr Gly Arg Asn Asn Gly 
    210                 215                 220                 


Met Pro Pro Arg Ala Cys Thr Lys Val Ser Ser Phe Val His Trp Ile 
225                 230                 235                 240 


Lys Lys Thr Met Lys Arg Tyr 
                245         


<210>  6349
<211>  90
<212>  PRT
<213>  Homo Sapiens

<400>  6349

Met Gln Pro Ile Leu Leu Leu Leu Ala Phe Leu Leu Leu Pro Arg Ala 
1               5                   10                  15      


Asp Ala Gly Glu Ile Ile Gly Gly His Glu Ala Lys Pro His Ser Arg 
            20                  25                  30          


Pro Tyr Met Ala Tyr Leu Met Ile Trp Asp Gln Lys Ser Leu Lys Arg 
        35                  40                  45              


Cys Gly Gly Phe Leu Ile Arg Asp Asp Phe Val Leu Thr Ala Ala His 
    50                  55                  60                  


Cys Trp Gly Ser Trp Arg Glu Arg Pro Ser Gly Pro Glu Leu Cys Ser 
65                  70                  75                  80  


Pro Ser Gly Tyr Leu Ala Thr Arg Pro Arg 
                85                  90  


<210>  6350
<211>  90
<212>  PRT
<213>  Homo Sapiens

<400>  6350

Met Gln Pro Ile Leu Leu Leu Leu Ala Phe Leu Leu Leu Pro Arg Ala 
1               5                   10                  15      


Asp Ala Gly Glu Ile Ile Gly Gly His Glu Ala Lys Pro His Ser Arg 
            20                  25                  30          


Pro Tyr Met Ala Tyr Leu Met Ile Trp Asp Gln Lys Ser Leu Lys Arg 
        35                  40                  45              


Cys Gly Gly Phe Leu Ile Arg Asp Asp Phe Val Leu Thr Ala Ala His 
    50                  55                  60                  


Cys Trp Gly Ser Trp Arg Glu Arg Pro Ser Gly Pro Glu Leu Cys Ser 
65                  70                  75                  80  


Pro Ser Gly Tyr Leu Ala Thr Arg Pro Arg 
                85                  90  


<210>  6351
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  6351

Met Gln Pro Ile Leu Leu Leu Leu Ala Phe Leu Leu Leu Pro Arg Ala 
1               5                   10                  15      


Asp Gln Leu Glu Arg Lys Ala Lys Arg Thr Arg Ala Val Gln Pro Leu 
            20                  25                  30          


Arg Leu Pro Ser Asn Lys Ala Gln Val Lys Pro Gly Gln Thr Cys Ser 
        35                  40                  45              


Val Ala Gly Trp Gly Gln Thr Ala Pro Leu Gly Lys His Ser His Thr 
    50                  55                  60                  


Leu Gln Glu Val Lys Met Thr Val Gln Glu Asp Arg Lys Cys Glu Ser 
65                  70                  75                  80  


Asp Leu Arg His Tyr Tyr Asp Ser Thr Ile Glu Leu Cys Val Gly Asp 
                85                  90                  95      


Pro Glu Ile Lys Lys Thr Ser Phe Lys Gly Asp Ser Gly Gly Pro Leu 
            100                 105                 110         


Val Cys Asn Lys Val Ala Gln Gly Ile Val Ser Tyr Gly Arg Asn Asn 
        115                 120                 125             


Gly Met Pro Pro Arg Ala Cys Thr Lys Val Ser Ser Phe Val His Trp 
    130                 135                 140                 


Ile Lys Lys Thr Met Lys Arg Tyr 
145                 150         


<210>  6352
<211>  235
<212>  PRT
<213>  Homo Sapiens

<400>  6352

Met Gln Thr Phe Pro Ser Gly Glu Ile Ile Gly Gly His Glu Ala Lys 
1               5                   10                  15      


Pro His Ser Arg Pro Tyr Met Ala Tyr Leu Met Ile Trp Asp Gln Lys 
            20                  25                  30          


Ser Leu Lys Arg Cys Gly Gly Phe Leu Ile Arg Asp Asp Phe Val Leu 
        35                  40                  45              


Thr Ala Ala His Cys Trp Gly Ser Ser Ile Asn Val Thr Leu Gly Ala 
    50                  55                  60                  


His Asn Ile Lys Glu Gln Glu Pro Thr Gln Gln Phe Ile Pro Val Lys 
65                  70                  75                  80  


Arg Pro Ile Pro His Pro Ala Tyr Asn Pro Lys Asn Phe Ser Asn Asp 
                85                  90                  95      


Ile Met Leu Leu Gln Leu Glu Arg Lys Ala Lys Arg Thr Arg Ala Val 
            100                 105                 110         


Gln Pro Leu Arg Leu Pro Ser Asn Lys Ala Gln Val Lys Pro Gly Gln 
        115                 120                 125             


Thr Cys Ser Val Ala Gly Trp Gly Gln Thr Ala Pro Leu Gly Lys His 
    130                 135                 140                 


Ser His Thr Leu Gln Glu Val Lys Met Thr Val Gln Glu Asp Arg Lys 
145                 150                 155                 160 


Cys Glu Ser Asp Leu Arg His Tyr Tyr Asp Ser Thr Ile Glu Leu Cys 
                165                 170                 175     


Val Gly Asp Pro Glu Ile Lys Lys Thr Ser Phe Lys Gly Asp Ser Gly 
            180                 185                 190         


Gly Pro Leu Val Cys Asn Lys Val Ala Gln Gly Ile Val Ser Tyr Gly 
        195                 200                 205             


Arg Asn Asn Gly Met Pro Pro Arg Ala Cys Thr Lys Val Ser Ser Phe 
    210                 215                 220                 


Val His Trp Ile Lys Lys Thr Met Lys Arg Tyr 
225                 230                 235 


<210>  6353
<211>  115
<212>  PRT
<213>  Homo Sapiens

<400>  6353

Met Gln Pro Phe Leu Leu Leu Leu Ala Phe Leu Leu Thr Pro Gly Ala 
1               5                   10                  15      


Gly Thr Glu Glu Ile Ile Gly Gly His Glu Ala Lys Pro His Ser Arg 
            20                  25                  30          


Pro Tyr Met Ala Phe Val Gln Phe Leu Gln Glu Lys Ser Arg Lys Arg 
        35                  40                  45              


Cys Gly Gly Ile Leu Val Arg Lys Asp Phe Val Leu Thr Ala Ala His 
    50                  55                  60                  


Cys Gln Gly Arg Gly Asp Ser Gly Gly Pro Leu Val Cys Lys Asp Val 
65                  70                  75                  80  


Ala Gln Gly Ile Leu Ser Tyr Gly Asn Lys Lys Gly Thr Pro Pro Gly 
                85                  90                  95      


Val Tyr Ile Lys Val Ser His Phe Leu Pro Trp Ile Lys Arg Thr Met 
            100                 105                 110         


Lys Arg Leu 
        115 


<210>  6354
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  6354

Met Gln Pro Phe Leu Leu Leu Leu Ala Phe Leu Leu Thr Pro Gly Ala 
1               5                   10                  15      


Gly Thr Glu Glu Ile Ile Gly Gly His Glu Ala Lys Pro His Ser Arg 
            20                  25                  30          


Pro Tyr Met Ala Phe Val Gln Phe Leu Gln Glu Lys Ser Arg Lys Arg 
        35                  40                  45              


Cys Gly Gly Ile Leu Val Arg Lys Asp Phe Val Leu Thr Ala Ala His 
    50                  55                  60                  


Cys Gln Gly Ser Ser Ile Asn Val Thr Leu Gly Ala His Asn Ile Lys 
65                  70                  75                  80  


Glu Gln Glu Arg Thr Gln Gln Phe Ile Pro Val Lys Arg Pro Ile Pro 
                85                  90                  95      


His Pro Ala Tyr Asn Pro Lys Asn Phe Ser Asn Asp Ile Met Leu Leu 
            100                 105                 110         


Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Lys Asp Val Ala Gln Gly 
        115                 120                 125             


Ile Leu Ser Tyr Gly Asn Lys Lys Gly Thr Pro Pro Gly Val Tyr Ile 
    130                 135                 140                 


Lys Val Ser His Phe Leu Pro Trp Ile Lys Arg Thr Met Lys Arg Leu 
145                 150                 155                 160 


<210>  6355
<211>  246
<212>  PRT
<213>  Homo Sapiens

<400>  6355

Met Gln Pro Phe Leu Leu Leu Leu Ala Phe Leu Leu Thr Pro Gly Ala 
1               5                   10                  15      


Gly Thr Glu Glu Ile Ile Gly Gly His Glu Ala Lys Pro His Ser Arg 
            20                  25                  30          


Pro Tyr Met Ala Phe Val Gln Phe Leu Gln Glu Lys Ser Arg Lys Arg 
        35                  40                  45              


Cys Gly Gly Ile Leu Val Arg Lys Asp Phe Val Leu Thr Ala Ala His 
    50                  55                  60                  


Cys Gln Gly Ser Ser Ile Asn Val Thr Leu Gly Ala His Asn Ile Lys 
65                  70                  75                  80  


Glu Gln Glu Arg Thr Gln Gln Phe Ile Pro Val Lys Arg Pro Ile Pro 
                85                  90                  95      


His Pro Ala Tyr Asn Pro Lys Asn Phe Ser Asn Asp Ile Met Leu Leu 
            100                 105                 110         


Gln Leu Glu Arg Lys Ala Lys Trp Thr Thr Ala Val Arg Pro Leu Arg 
        115                 120                 125             


Leu Pro Ser Ser Lys Ala Gln Val Lys Pro Gly Gln Leu Cys Ser Val 
    130                 135                 140                 


Ala Gly Trp Gly Tyr Val Ser Met Ser Thr Leu Ala Thr Thr Leu Gln 
145                 150                 155                 160 


Glu Val Leu Leu Thr Val Gln Lys Asp Cys Gln Cys Glu Arg Leu Phe 
                165                 170                 175     


His Gly Asn Tyr Ser Arg Ala Thr Glu Ile Cys Val Gly Asp Pro Lys 
            180                 185                 190         


Lys Thr Gln Thr Gly Phe Lys Gly Asp Ser Gly Gly Pro Leu Val Cys 
        195                 200                 205             


Lys Asp Val Ala Gln Gly Ile Leu Ser Tyr Gly Asn Lys Lys Gly Thr 
    210                 215                 220                 


Pro Pro Gly Val Tyr Ile Lys Val Ser His Phe Leu Pro Trp Ile Lys 
225                 230                 235                 240 


Arg Thr Met Lys Arg Leu 
                245     


<210>  6356
<211>  264
<212>  PRT
<213>  Homo Sapiens

<400>  6356

Met Thr Lys Phe Ser Ser Phe Ser Leu Phe Phe Leu Ile Val Gly Ala 
1               5                   10                  15      


Tyr Met Thr His Val Cys Phe Asn Met Glu Ile Ile Gly Gly Lys Glu 
            20                  25                  30          


Val Ser Pro His Ser Arg Pro Phe Met Ala Ser Ile Gln Tyr Gly Gly 
        35                  40                  45              


His His Val Cys Gly Gly Val Leu Ile Asp Pro Gln Trp Val Leu Thr 
    50                  55                  60                  


Ala Ala His Cys Gln Tyr Arg Phe Thr Lys Gly Gln Ser Pro Thr Val 
65                  70                  75                  80  


Val Leu Gly Ala His Ser Leu Ser Lys Asn Glu Ala Ser Lys Gln Thr 
                85                  90                  95      


Leu Glu Ile Lys Lys Phe Ile Pro Phe Ser Arg Val Thr Ser Asp Pro 
            100                 105                 110         


Gln Ser Asn Asp Ile Met Leu Val Lys Leu Gln Thr Ala Ala Lys Leu 
        115                 120                 125             


Asn Lys His Val Lys Met Leu His Ile Arg Ser Lys Thr Ser Leu Arg 
    130                 135                 140                 


Ser Gly Thr Lys Cys Lys Val Thr Gly Trp Gly Ala Thr Asp Pro Asp 
145                 150                 155                 160 


Ser Leu Arg Pro Ser Asp Thr Leu Arg Glu Val Thr Val Thr Val Leu 
                165                 170                 175     


Ser Arg Lys Leu Cys Asn Ser Gln Ser Tyr Tyr Asn Gly Asp Pro Phe 
            180                 185                 190         


Ile Thr Lys Asp Met Val Cys Ala Gly Asp Ala Lys Gly Gln Lys Asp 
        195                 200                 205             


Ser Cys Lys Gly Asp Ser Gly Gly Pro Leu Ile Cys Lys Gly Val Phe 
    210                 215                 220                 


His Ala Ile Val Ser Gly Gly His Glu Cys Gly Val Ala Thr Lys Pro 
225                 230                 235                 240 


Gly Ile Tyr Thr Leu Leu Thr Lys Lys Tyr Gln Thr Trp Ile Lys Ser 
                245                 250                 255     


Asn Leu Val Pro Pro His Thr Asn 
            260                 


<210>  6357
<211>  218
<212>  PRT
<213>  Homo Sapiens

<400>  6357

Met Ala Ser Leu Gln Arg Asn Gly Ser His Leu Cys Gly Gly Val Leu 
1               5                   10                  15      


Val His Pro Lys Trp Val Leu Thr Ala Ala His Cys Leu Ala Gln Arg 
            20                  25                  30          


Met Ala Gln Leu Arg Leu Val Leu Gly Leu His Thr Leu Asp Ser Pro 
        35                  40                  45              


Gly Leu Thr Phe His Ile Lys Ala Ala Ile Gln His Pro Arg Tyr Lys 
    50                  55                  60                  


Pro Val Pro Ala Leu Glu Asn Asp Leu Ala Leu Leu Gln Leu Asp Gly 
65                  70                  75                  80  


Lys Val Lys Pro Ser Arg Thr Ile Arg Pro Leu Ala Leu Pro Ser Lys 
                85                  90                  95      


Arg Gln Val Val Ala Ala Gly Thr Arg Cys Ser Met Ala Gly Trp Gly 
            100                 105                 110         


Leu Thr His Gln Gly Gly Arg Leu Ser Arg Val Leu Arg Glu Leu Asp 
        115                 120                 125             


Leu Gln Val Leu Asp Thr Arg Met Cys Asn Asn Ser Arg Phe Trp Asn 
    130                 135                 140                 


Gly Ser Leu Ser Pro Ser Met Val Cys Leu Ala Ala Asp Ser Lys Asp 
145                 150                 155                 160 


Gln Ala Pro Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Cys Gly Lys 
                165                 170                 175     


Gly Arg Val Leu Ala Arg Val Leu Ser Phe Ser Ser Arg Val Cys Thr 
            180                 185                 190         


Asp Ile Phe Lys Pro Pro Val Ala Thr Ala Val Ala Pro Tyr Val Ser 
        195                 200                 205             


Trp Ile Arg Lys Val Thr Gly Arg Ser Ala 
    210                 215             


<210>  6358
<211>  257
<212>  PRT
<213>  Homo Sapiens

<400>  6358

Met Glu Ala Cys Val Ser Ser Leu Leu Val Leu Ala Leu Gly Ala Leu 
1               5                   10                  15      


Ser Val Gly Ser Ser Phe Gly Thr Gln Ile Ile Gly Gly Arg Glu Val 
            20                  25                  30          


Ile Pro His Ser Arg Pro Tyr Met Ala Ser Leu Gln Arg Asn Gly Ser 
        35                  40                  45              


His Leu Cys Gly Gly Val Leu Val His Pro Lys Trp Val Leu Thr Ala 
    50                  55                  60                  


Ala His Cys Leu Ala Gln Arg Met Ala Gln Leu Arg Leu Val Leu Gly 
65                  70                  75                  80  


Leu His Thr Leu Asp Ser Pro Gly Leu Thr Phe His Ile Lys Ala Ala 
                85                  90                  95      


Ile Gln His Pro Arg Tyr Lys Pro Val Pro Ala Leu Glu Asn Asp Leu 
            100                 105                 110         


Ala Leu Leu Gln Leu Asp Gly Lys Val Lys Pro Ser Arg Thr Ile Arg 
        115                 120                 125             


Pro Leu Ala Leu Pro Ser Lys Arg Gln Val Val Ala Ala Gly Thr Arg 
    130                 135                 140                 


Cys Ser Met Ala Gly Trp Gly Leu Thr His Gln Gly Gly Arg Leu Ser 
145                 150                 155                 160 


Arg Val Leu Arg Glu Leu Asp Leu Gln Val Leu Asp Thr Arg Met Cys 
                165                 170                 175     


Asn Asn Ser Arg Phe Trp Asn Gly Ser Leu Ser Pro Ser Met Val Cys 
            180                 185                 190         


Leu Ala Ala Asp Ser Lys Asp Gln Ala Pro Cys Lys Gly Asp Ser Gly 
        195                 200                 205             


Gly Pro Leu Val Cys Gly Lys Gly Arg Val Leu Ala Arg Val Leu Ser 
    210                 215                 220                 


Phe Ser Ser Arg Val Cys Thr Asp Ile Phe Lys Pro Pro Val Ala Thr 
225                 230                 235                 240 


Ala Val Ala Pro Tyr Val Ser Trp Ile Arg Lys Val Thr Gly Arg Ser 
                245                 250                 255     


Ala 
    


<210>  6359
<211>  802
<212>  PRT
<213>  Homo Sapiens

<400>  6359

Met Leu Ala Glu Pro Phe Asn Trp His Pro Gly Met Trp Asn Met Leu 
1               5                   10                  15      


Ile Val Ala Met Cys Leu Ala Leu Leu Gly Cys Leu Gln Ala Gln Glu 
            20                  25                  30          


Leu Gln Gly His Val Ser Ile Ile Leu Leu Gly Ala Thr Gly Asp Leu 
        35                  40                  45              


Ala Lys Lys Tyr Leu Trp Gln Gly Leu Phe Gln Leu Tyr Leu Asp Glu 
    50                  55                  60                  


Ala Gly Arg Gly His Ser Phe Ser Phe His Gly Ala Ala Leu Thr Ala 
65                  70                  75                  80  


Pro Lys Gln Gly Gln Glu Leu Met Ala Lys Ala Leu Glu Ser Leu Ser 
                85                  90                  95      


Cys Pro Lys Asp Met Ala Pro Ser His Cys Ala Glu His Lys Asp Gln 
            100                 105                 110         


Phe Leu Gln Leu Ser Gln Tyr Arg Gln Leu Lys Thr Ala Glu Asp Tyr 
        115                 120                 125             


Gln Ala Leu Asn Lys Asp Ile Glu Ala Gln Leu Gln His Ala Gly Leu 
    130                 135                 140                 


Arg Glu Ala Gly Arg Ile Phe Tyr Phe Ser Val Pro Pro Phe Ala Tyr 
145                 150                 155                 160 


Glu Asp Ile Ala Arg Asn Ile Asn Ser Ser Cys Arg Pro Gly Pro Gly 
                165                 170                 175     


Ala Trp Leu Arg Val Val Leu Glu Lys Pro Phe Gly His Asp His Phe 
            180                 185                 190         


Ser Ala Gln Gln Leu Ala Thr Glu Leu Gly Thr Phe Phe Gln Glu Glu 
        195                 200                 205             


Glu Met Tyr Arg Val Asp His Tyr Leu Gly Lys Gln Ala Val Ala Gln 
    210                 215                 220                 


Ile Leu Pro Phe Arg Asp Gln Asn Arg Lys Ala Leu Asp Gly Leu Trp 
225                 230                 235                 240 


Asn Arg His His Val Glu Arg Val Glu Ile Ile Met Lys Glu Thr Val 
                245                 250                 255     


Asp Ala Glu Gly Arg Thr Ser Phe Tyr Glu Glu Tyr Gly Val Ile Arg 
            260                 265                 270         


Asp Val Leu Gln Asn His Leu Thr Glu Val Leu Thr Leu Val Ala Met 
        275                 280                 285             


Glu Leu Pro His Asn Val Ser Ser Ala Glu Ala Val Leu Arg His Lys 
    290                 295                 300                 


Leu Gln Val Phe Gln Ala Leu Arg Gly Leu Gln Arg Gly Ser Ala Val 
305                 310                 315                 320 


Val Gly Gln Tyr Gln Ser Tyr Ser Glu Gln Val Arg Arg Glu Leu Gln 
                325                 330                 335     


Lys Pro Asp Ser Phe His Ser Leu Thr Pro Thr Phe Ala Ala Val Leu 
            340                 345                 350         


Val His Ile Asp Asn Leu Arg Trp Glu Gly Val Pro Phe Ile Leu Met 
        355                 360                 365             


Ser Gly Lys Ala Leu Asp Glu Arg Val Gly Tyr Ala Arg Ile Leu Phe 
    370                 375                 380                 


Lys Asn Gln Ala Cys Cys Val Gln Ser Glu Lys His Trp Ala Ala Ala 
385                 390                 395                 400 


Gln Ser Gln Cys Leu Pro Arg Gln Leu Val Phe His Ile Gly His Gly 
                405                 410                 415     


Asp Leu Gly Ser Pro Ala Val Leu Val Ser Arg Asn Leu Phe Arg Pro 
            420                 425                 430         


Ser Leu Pro Ser Ser Trp Lys Glu Met Glu Gly Pro Pro Gly Leu Arg 
        435                 440                 445             


Leu Phe Gly Ser Pro Leu Ser Asp Tyr Tyr Ala Tyr Ser Pro Val Arg 
    450                 455                 460                 


Glu Arg Asp Ala His Ser Val Leu Leu Ser His Ile Phe His Gly Arg 
465                 470                 475                 480 


Lys Asn Phe Phe Ile Thr Thr Glu Asn Leu Leu Ala Ser Trp Asn Phe 
                485                 490                 495     


Trp Thr Pro Leu Leu Glu Ser Leu Ala His Lys Ala Pro Arg Leu Tyr 
            500                 505                 510         


Pro Gly Gly Ala Glu Asn Gly Arg Leu Leu Asp Phe Glu Phe Ser Ser 
        515                 520                 525             


Gly Arg Leu Phe Phe Ser Gln Gln Gln Pro Glu Gln Leu Val Pro Gly 
    530                 535                 540                 


Pro Gly Pro Ala Pro Met Pro Ser Asp Phe Gln Val Leu Arg Ala Lys 
545                 550                 555                 560 


Tyr Arg Glu Ser Pro Leu Val Ser Ala Trp Ser Glu Glu Leu Ile Ser 
                565                 570                 575     


Lys Leu Ala Asn Asp Ile Glu Ala Thr Ala Val Arg Ala Val Arg Arg 
            580                 585                 590         


Phe Gly Gln Phe His Leu Ala Leu Ser Gly Gly Ser Ser Pro Val Ala 
        595                 600                 605             


Leu Phe Gln Gln Leu Ala Thr Ala His Tyr Gly Phe Pro Trp Ala His 
    610                 615                 620                 


Thr His Leu Trp Leu Val Asp Glu Arg Cys Val Pro Leu Ser Asp Pro 
625                 630                 635                 640 


Glu Ser Asn Phe Gln Gly Leu Gln Ala His Leu Leu Gln His Val Arg 
                645                 650                 655     


Ile Pro Tyr Tyr Asn Ile His Pro Met Pro Val His Leu Gln Gln Arg 
            660                 665                 670         


Leu Cys Ala Glu Glu Asp Gln Gly Ala Gln Ile Tyr Ala Arg Glu Ile 
        675                 680                 685             


Ser Ala Leu Val Ala Asn Ser Ser Phe Asp Leu Val Leu Leu Gly Met 
    690                 695                 700                 


Gly Ala Asp Gly His Thr Ala Ser Leu Phe Pro Gln Ser Pro Thr Gly 
705                 710                 715                 720 


Leu Asp Gly Glu Gln Leu Val Val Leu Thr Thr Ser Pro Ser Gln Pro 
                725                 730                 735     


His Arg Arg Met Ser Leu Ser Leu Pro Leu Ile Asn Arg Ala Lys Lys 
            740                 745                 750         


Val Ala Val Leu Val Met Gly Arg Met Lys Arg Glu Ile Thr Thr Leu 
        755                 760                 765             


Val Ser Arg Val Gly His Glu Pro Lys Lys Trp Pro Ile Ser Gly Val 
    770                 775                 780                 


Leu Pro His Ser Gly Gln Leu Val Trp Tyr Met Asp Tyr Asp Ala Phe 
785                 790                 795                 800 


Leu Gly 
        


<210>  6360
<211>  791
<212>  PRT
<213>  Homo Sapiens

<400>  6360

Met Trp Asn Met Leu Ile Val Ala Met Cys Leu Ala Leu Leu Gly Cys 
1               5                   10                  15      


Leu Gln Ala Gln Glu Leu Gln Gly His Val Ser Ile Ile Leu Leu Gly 
            20                  25                  30          


Ala Thr Gly Asp Leu Ala Lys Lys Tyr Leu Trp Gln Gly Leu Phe Gln 
        35                  40                  45              


Leu Tyr Leu Asp Glu Ala Gly Arg Gly His Ser Phe Ser Phe His Gly 
    50                  55                  60                  


Ala Ala Leu Thr Ala Pro Lys Gln Gly Gln Glu Leu Met Ala Lys Ala 
65                  70                  75                  80  


Leu Glu Ser Leu Ser Cys Pro Lys Asp Met Ala Pro Ser His Cys Ala 
                85                  90                  95      


Glu His Lys Asp Gln Phe Leu Gln Leu Ser Gln Tyr Arg Gln Leu Lys 
            100                 105                 110         


Thr Ala Glu Asp Tyr Gln Ala Leu Asn Lys Asp Ile Glu Ala Gln Leu 
        115                 120                 125             


Gln His Ala Gly Leu Arg Glu Ala Gly Arg Ile Phe Tyr Phe Ser Val 
    130                 135                 140                 


Pro Pro Phe Ala Tyr Glu Asp Ile Ala Arg Asn Ile Asn Ser Ser Cys 
145                 150                 155                 160 


Arg Pro Gly Pro Gly Ala Trp Leu Arg Val Val Leu Glu Lys Pro Phe 
                165                 170                 175     


Gly His Asp His Phe Ser Ala Gln Gln Leu Ala Thr Glu Leu Gly Thr 
            180                 185                 190         


Phe Phe Gln Glu Glu Glu Met Tyr Arg Val Asp His Tyr Leu Gly Lys 
        195                 200                 205             


Gln Ala Val Ala Gln Ile Leu Pro Phe Arg Asp Gln Asn Arg Lys Ala 
    210                 215                 220                 


Leu Asp Gly Leu Trp Asn Arg His His Val Glu Arg Val Glu Ile Ile 
225                 230                 235                 240 


Met Lys Glu Thr Val Asp Ala Glu Gly Arg Thr Ser Phe Tyr Glu Glu 
                245                 250                 255     


Tyr Gly Val Ile Arg Asp Val Leu Gln Asn His Leu Thr Glu Val Leu 
            260                 265                 270         


Thr Leu Val Ala Met Glu Leu Pro His Asn Val Ser Ser Ala Glu Ala 
        275                 280                 285             


Val Leu Arg His Lys Leu Gln Val Phe Gln Ala Leu Arg Gly Leu Gln 
    290                 295                 300                 


Arg Gly Ser Ala Val Val Gly Gln Tyr Gln Ser Tyr Ser Glu Gln Val 
305                 310                 315                 320 


Arg Arg Glu Leu Gln Lys Pro Asp Ser Phe His Ser Leu Thr Pro Thr 
                325                 330                 335     


Phe Ala Ala Val Leu Val His Ile Asp Asn Leu Arg Trp Glu Gly Val 
            340                 345                 350         


Pro Phe Ile Leu Met Ser Gly Lys Ala Leu Asp Glu Arg Val Gly Tyr 
        355                 360                 365             


Ala Arg Ile Leu Phe Lys Asn Gln Ala Cys Cys Val Gln Ser Glu Lys 
    370                 375                 380                 


His Trp Ala Ala Ala Gln Ser Gln Cys Leu Pro Arg Gln Leu Val Phe 
385                 390                 395                 400 


His Ile Gly His Gly Asp Leu Gly Ser Pro Ala Val Leu Val Ser Arg 
                405                 410                 415     


Asn Leu Phe Arg Pro Ser Leu Pro Ser Ser Trp Lys Glu Met Glu Gly 
            420                 425                 430         


Pro Pro Gly Leu Arg Leu Phe Gly Ser Pro Leu Ser Asp Tyr Tyr Ala 
        435                 440                 445             


Tyr Ser Pro Val Arg Glu Arg Asp Ala His Ser Val Leu Leu Ser His 
    450                 455                 460                 


Ile Phe His Gly Arg Lys Asn Phe Phe Ile Thr Thr Glu Asn Leu Leu 
465                 470                 475                 480 


Ala Ser Trp Asn Phe Trp Thr Pro Leu Leu Glu Ser Leu Ala His Lys 
                485                 490                 495     


Ala Pro Arg Leu Tyr Pro Gly Gly Ala Glu Asn Gly Arg Leu Leu Asp 
            500                 505                 510         


Phe Glu Phe Ser Ser Gly Arg Leu Phe Phe Ser Gln Gln Gln Pro Glu 
        515                 520                 525             


Gln Leu Val Pro Gly Pro Gly Pro Ala Pro Met Pro Ser Asp Phe Gln 
    530                 535                 540                 


Val Leu Arg Ala Lys Tyr Arg Glu Ser Pro Leu Val Ser Ala Trp Ser 
545                 550                 555                 560 


Glu Glu Leu Ile Ser Lys Leu Ala Asn Asp Ile Glu Ala Thr Ala Val 
                565                 570                 575     


Arg Ala Val Arg Arg Phe Gly Gln Phe His Leu Ala Leu Ser Gly Gly 
            580                 585                 590         


Ser Ser Pro Val Ala Leu Phe Gln Gln Leu Ala Thr Ala His Tyr Gly 
        595                 600                 605             


Phe Pro Trp Ala His Thr His Leu Trp Leu Val Asp Glu Arg Cys Val 
    610                 615                 620                 


Pro Leu Ser Asp Pro Glu Ser Asn Phe Gln Gly Leu Gln Ala His Leu 
625                 630                 635                 640 


Leu Gln His Val Arg Ile Pro Tyr Tyr Asn Ile His Pro Met Pro Val 
                645                 650                 655     


His Leu Gln Gln Arg Leu Cys Ala Glu Glu Asp Gln Gly Ala Gln Ile 
            660                 665                 670         


Tyr Ala Arg Glu Ile Ser Ala Leu Val Ala Asn Ser Ser Phe Asp Leu 
        675                 680                 685             


Val Leu Leu Gly Met Gly Ala Asp Gly His Thr Ala Ser Leu Phe Pro 
    690                 695                 700                 


Gln Ser Pro Thr Gly Leu Asp Gly Glu Gln Leu Val Val Leu Thr Thr 
705                 710                 715                 720 


Ser Pro Ser Gln Pro His Arg Arg Met Ser Leu Ser Leu Pro Leu Ile 
                725                 730                 735     


Asn Arg Ala Lys Lys Val Ala Val Leu Val Met Gly Arg Met Lys Arg 
            740                 745                 750         


Glu Ile Thr Thr Leu Val Ser Arg Val Gly His Glu Pro Lys Lys Trp 
        755                 760                 765             


Pro Ile Ser Gly Val Leu Pro His Ser Gly Gln Leu Val Trp Tyr Met 
    770                 775                 780                 


Asp Tyr Asp Ala Phe Leu Gly 
785                 790     


<210>  6361
<211>  560
<212>  PRT
<213>  Homo Sapiens

<400>  6361

Met Phe Ala Arg Met Ser Asp Leu His Val Leu Leu Leu Met Ala Leu 
1               5                   10                  15      


Val Gly Lys Thr Ala Cys Gly Phe Ser Leu Met Ser Leu Leu Glu Ser 
            20                  25                  30          


Leu Asp Pro Asp Trp Thr Pro Asp Gln Tyr Asp Tyr Ser Tyr Glu Asp 
        35                  40                  45              


Tyr Asn Gln Glu Glu Asn Thr Ser Ser Thr Leu Thr His Ala Glu Asn 
    50                  55                  60                  


Pro Asp Trp Tyr Tyr Thr Glu Asp Gln Ala Asp Pro Cys Gln Pro Asn 
65                  70                  75                  80  


Pro Cys Glu His Gly Gly Asp Cys Leu Val His Gly Ser Thr Phe Thr 
                85                  90                  95      


Cys Ser Cys Leu Ala Pro Phe Ser Gly Asn Lys Cys Gln Lys Val Gln 
            100                 105                 110         


Asn Thr Cys Lys Asp Asn Pro Cys Gly Arg Gly Gln Cys Leu Ile Thr 
        115                 120                 125             


Gln Ser Pro Pro Tyr Tyr Arg Cys Val Cys Lys His Pro Tyr Thr Gly 
    130                 135                 140                 


Pro Ser Cys Ser Gln Val Val Pro Val Cys Arg Pro Asn Pro Cys Gln 
145                 150                 155                 160 


Asn Gly Ala Thr Cys Ser Arg His Lys Arg Arg Ser Lys Phe Thr Cys 
                165                 170                 175     


Ala Cys Pro Asp Gln Phe Lys Gly Lys Phe Cys Glu Ile Gly Ser Asp 
            180                 185                 190         


Asp Cys Tyr Val Gly Asp Gly Tyr Ser Tyr Arg Gly Lys Met Asn Arg 
        195                 200                 205             


Thr Val Asn Gln His Ala Cys Leu Tyr Trp Asn Ser His Leu Leu Leu 
    210                 215                 220                 


Gln Glu Asn Tyr Asn Met Phe Met Glu Asp Ala Glu Thr His Gly Ile 
225                 230                 235                 240 


Gly Glu His Asn Phe Cys Arg Asn Pro Asp Ala Asp Glu Lys Pro Trp 
                245                 250                 255     


Cys Phe Ile Lys Val Thr Asn Asp Lys Val Lys Trp Glu Tyr Cys Asp 
            260                 265                 270         


Val Ser Ala Cys Ser Ala Gln Asp Val Ala Tyr Pro Glu Glu Ser Pro 
        275                 280                 285             


Thr Glu Pro Ser Thr Lys Leu Pro Gly Phe Asp Ser Cys Gly Lys Thr 
    290                 295                 300                 


Glu Ile Ala Glu Arg Lys Ile Lys Arg Ile Tyr Gly Gly Phe Lys Ser 
305                 310                 315                 320 


Thr Ala Gly Lys His Pro Trp Gln Ala Ser Leu Gln Ser Ser Leu Pro 
                325                 330                 335     


Leu Thr Ile Ser Met Pro Gln Gly His Phe Cys Gly Gly Ala Leu Ile 
            340                 345                 350         


His Pro Cys Trp Val Leu Thr Ala Ala His Cys Thr Asp Ile Lys Thr 
        355                 360                 365             


Arg His Leu Lys Val Val Leu Gly Asp Gln Asp Leu Lys Lys Glu Glu 
    370                 375                 380                 


Phe His Glu Gln Ser Phe Arg Val Glu Lys Ile Phe Lys Tyr Ser His 
385                 390                 395                 400 


Tyr Asn Glu Arg Asp Glu Ile Pro His Asn Asp Ile Ala Leu Leu Lys 
                405                 410                 415     


Leu Lys Pro Val Asp Gly His Cys Ala Leu Glu Ser Lys Tyr Val Lys 
            420                 425                 430         


Thr Val Cys Leu Pro Asp Gly Ser Phe Pro Ser Gly Ser Glu Cys His 
        435                 440                 445             


Ile Ser Gly Trp Gly Val Thr Glu Thr Gly Lys Gly Ser Arg Gln Leu 
    450                 455                 460                 


Leu Asp Ala Lys Val Lys Leu Ile Ala Asn Thr Leu Cys Asn Ser Arg 
465                 470                 475                 480 


Gln Leu Tyr Asp His Met Ile Asp Asp Ser Met Ile Cys Ala Gly Asn 
                485                 490                 495     


Leu Gln Lys Pro Gly Gln Asp Thr Cys Gln Gly Asp Ser Gly Gly Pro 
            500                 505                 510         


Leu Thr Cys Glu Lys Asp Gly Thr Tyr Tyr Val Tyr Gly Ile Val Ser 
        515                 520                 525             


Trp Gly Leu Glu Cys Gly Lys Arg Pro Gly Val Tyr Thr Gln Val Thr 
    530                 535                 540                 


Lys Phe Leu Asn Trp Ile Lys Ala Thr Ile Lys Ser Glu Ser Gly Phe 
545                 550                 555                 560 


<210>  6362
<211>  534
<212>  PRT
<213>  Homo Sapiens

<400>  6362

Met Ser Leu Leu Glu Ser Leu Asp Pro Asp Trp Thr Pro Asp Gln Tyr 
1               5                   10                  15      


Asp Tyr Ser Tyr Glu Asp Tyr Asn Gln Glu Glu Asn Thr Ser Ser Thr 
            20                  25                  30          


Leu Thr His Ala Glu Asn Pro Asp Trp Tyr Tyr Thr Glu Asp Gln Ala 
        35                  40                  45              


Asp Pro Cys Gln Pro Asn Pro Cys Glu His Gly Gly Asp Cys Leu Val 
    50                  55                  60                  


His Gly Ser Thr Phe Thr Cys Ser Cys Leu Ala Pro Phe Ser Gly Asn 
65                  70                  75                  80  


Lys Cys Gln Lys Val Gln Asn Thr Cys Lys Asp Asn Pro Cys Gly Arg 
                85                  90                  95      


Gly Gln Cys Leu Ile Thr Gln Ser Pro Pro Tyr Tyr Arg Cys Val Cys 
            100                 105                 110         


Lys His Pro Tyr Thr Gly Pro Ser Cys Ser Gln Val Val Pro Val Cys 
        115                 120                 125             


Arg Pro Asn Pro Cys Gln Asn Gly Ala Thr Cys Ser Arg His Lys Arg 
    130                 135                 140                 


Arg Ser Lys Phe Thr Cys Ala Cys Pro Asp Gln Phe Lys Gly Lys Phe 
145                 150                 155                 160 


Cys Glu Ile Gly Ser Asp Asp Cys Tyr Val Gly Asp Gly Tyr Ser Tyr 
                165                 170                 175     


Arg Gly Lys Met Asn Arg Thr Val Asn Gln His Ala Cys Leu Tyr Trp 
            180                 185                 190         


Asn Ser His Leu Leu Leu Gln Glu Asn Tyr Asn Met Phe Met Glu Asp 
        195                 200                 205             


Ala Glu Thr His Gly Ile Gly Glu His Asn Phe Cys Arg Asn Pro Asp 
    210                 215                 220                 


Ala Asp Glu Lys Pro Trp Cys Phe Ile Lys Val Thr Asn Asp Lys Val 
225                 230                 235                 240 


Lys Trp Glu Tyr Cys Asp Val Ser Ala Cys Ser Ala Gln Asp Val Ala 
                245                 250                 255     


Tyr Pro Glu Glu Ser Pro Thr Glu Pro Ser Thr Lys Leu Pro Gly Phe 
            260                 265                 270         


Asp Ser Cys Gly Lys Thr Glu Ile Ala Glu Arg Lys Ile Lys Arg Ile 
        275                 280                 285             


Tyr Gly Gly Phe Lys Ser Thr Ala Gly Lys His Pro Trp Gln Ala Ser 
    290                 295                 300                 


Leu Gln Ser Ser Leu Pro Leu Thr Ile Ser Met Pro Gln Gly His Phe 
305                 310                 315                 320 


Cys Gly Gly Ala Leu Ile His Pro Cys Trp Val Leu Thr Ala Ala His 
                325                 330                 335     


Cys Thr Asp Ile Lys Thr Arg His Leu Lys Val Val Leu Gly Asp Gln 
            340                 345                 350         


Asp Leu Lys Lys Glu Glu Phe His Glu Gln Ser Phe Arg Val Glu Lys 
        355                 360                 365             


Ile Phe Lys Tyr Ser His Tyr Asn Glu Arg Asp Glu Ile Pro His Asn 
    370                 375                 380                 


Asp Ile Ala Leu Leu Lys Leu Lys Pro Val Asp Gly His Cys Ala Leu 
385                 390                 395                 400 


Glu Ser Lys Tyr Val Lys Thr Val Cys Leu Pro Asp Gly Ser Phe Pro 
                405                 410                 415     


Ser Gly Ser Glu Cys His Ile Ser Gly Trp Gly Val Thr Glu Thr Gly 
            420                 425                 430         


Lys Gly Ser Arg Gln Leu Leu Asp Ala Lys Val Lys Leu Ile Ala Asn 
        435                 440                 445             


Thr Leu Cys Asn Ser Arg Gln Leu Tyr Asp His Met Ile Asp Asp Ser 
    450                 455                 460                 


Met Ile Cys Ala Gly Asn Leu Gln Lys Pro Gly Gln Asp Thr Cys Gln 
465                 470                 475                 480 


Gly Asp Ser Gly Gly Pro Leu Thr Cys Glu Lys Asp Gly Thr Tyr Tyr 
                485                 490                 495     


Val Tyr Gly Ile Val Ser Trp Gly Leu Glu Cys Gly Lys Arg Pro Gly 
            500                 505                 510         


Val Tyr Thr Gln Val Thr Lys Phe Leu Asn Trp Ile Lys Ala Thr Ile 
        515                 520                 525             


Lys Ser Glu Ser Gly Phe 
    530                 


<210>  6363
<211>  459
<212>  PRT
<213>  Homo Sapiens

<400>  6363

Met Thr Ile Leu Thr Tyr Pro Phe Lys Asn Leu Pro Thr Ala Ser Lys 
1               5                   10                  15      


Trp Ala Leu Arg Phe Ser Ile Arg Pro Leu Ser Cys Ser Ser Gln Leu 
            20                  25                  30          


Arg Ala Ala Pro Ala Val Gln Thr Lys Thr Lys Lys Thr Leu Ala Lys 
        35                  40                  45              


Pro Asn Ile Arg Asn Val Val Val Val Asp Gly Val Arg Thr Pro Phe 
    50                  55                  60                  


Leu Leu Ser Gly Thr Ser Gly Leu Leu His Arg Thr Ser Val Pro Lys 
65                  70                  75                  80  


Glu Val Val Asp Tyr Ile Ile Phe Gly Thr Val Ile Gln Glu Val Lys 
                85                  90                  95      


Thr Ser Asn Val Ala Arg Glu Ala Ala Leu Gly Ala Gly Phe Ser Asp 
            100                 105                 110         


Lys Thr Pro Ala His Thr Val Thr Met Ala Cys Ile Ser Ala Asn Gln 
        115                 120                 125             


Ala Met Thr Thr Gly Val Gly Leu Ile Ala Ser Gly Gln Cys Asp Val 
    130                 135                 140                 


Ile Val Ala Gly Gly Val Glu Leu Met Ser Asp Val Pro Ile Arg His 
145                 150                 155                 160 


Ser Arg Lys Met Arg Lys Leu Met Leu Asp Leu Asn Lys Ala Lys Ser 
                165                 170                 175     


Met Gly Gln Arg Leu Ser Leu Ile Ser Lys Phe Arg Phe Asn Phe Leu 
            180                 185                 190         


Ala Pro Glu Leu Pro Ala Val Ser Glu Phe Ser Thr Ser Glu Thr Met 
        195                 200                 205             


Gly His Ser Ala Asp Arg Leu Ala Ala Ala Phe Ala Val Ser Arg Leu 
    210                 215                 220                 


Glu Gln Asp Glu Tyr Ala Leu Arg Ser His Ser Leu Ala Lys Lys Ala 
225                 230                 235                 240 


Gln Asp Glu Gly Leu Leu Ser Asp Val Val Pro Phe Lys Val Pro Gly 
                245                 250                 255     


Lys Asp Thr Val Thr Lys Asp Asn Gly Ile Arg Pro Ser Ser Leu Glu 
            260                 265                 270         


Gln Met Ala Lys Leu Lys Pro Ala Phe Ile Lys Pro Tyr Gly Thr Val 
        275                 280                 285             


Thr Ala Ala Asn Ser Ser Phe Leu Thr Asp Gly Ala Ser Ala Met Leu 
    290                 295                 300                 


Ile Met Ala Glu Glu Lys Ala Leu Ala Met Gly Tyr Lys Pro Lys Ala 
305                 310                 315                 320 


Tyr Leu Arg Asp Phe Met Tyr Val Ser Gln Asp Pro Lys Asp Gln Leu 
                325                 330                 335     


Leu Leu Gly Pro Thr Tyr Ala Thr Pro Lys Val Leu Glu Lys Ala Gly 
            340                 345                 350         


Leu Thr Met Asn Asp Ile Asp Ala Phe Glu Phe His Glu Ala Phe Ser 
        355                 360                 365             


Gly Gln Ile Leu Ala Asn Phe Lys Ala Met Asp Ser Asp Trp Phe Ala 
    370                 375                 380                 


Glu Asn Tyr Met Gly Arg Lys Thr Lys Val Gly Leu Pro Pro Leu Glu 
385                 390                 395                 400 


Lys Phe Asn Asn Trp Gly Gly Ser Leu Ser Leu Gly His Pro Phe Gly 
                405                 410                 415     


Ala Thr Gly Cys Arg Leu Val Met Ala Ala Ala Asn Arg Leu Arg Lys 
            420                 425                 430         


Glu Gly Gly Gln Tyr Gly Leu Val Ala Ala Cys Ala Ala Gly Gly Gln 
        435                 440                 445             


Gly His Ala Met Ile Val Glu Ala Tyr Pro Lys 
    450                 455                 


<210>  6364
<211>  85
<212>  PRT
<213>  Homo Sapiens

<400>  6364

Met Thr Ile Leu Thr Tyr Pro Phe Lys Asn Leu Pro Thr Ala Ser Lys 
1               5                   10                  15      


Trp Ala Leu Arg Phe Ser Ile Arg Pro Leu Ser Cys Ser Ser Gln Leu 
            20                  25                  30          


Arg Ala Ala Pro Ala Val Gln Thr Lys Thr Lys Lys Thr Leu Ala Lys 
        35                  40                  45              


Pro Asn Ile Arg Asn Val Val Val Val Asp Gly Val Arg Thr Pro Phe 
    50                  55                  60                  


Leu Leu Ser Gly Thr Ser Tyr Lys Asp Leu Met Pro His Asp Leu Ala 
65                  70                  75                  80  


Arg Ala Ala Leu Thr 
                85  


<210>  6365
<211>  351
<212>  PRT
<213>  Homo Sapiens

<400>  6365

Met Thr Ile Leu Thr Tyr Pro Phe Lys Asn Leu Pro Thr Ala Ser Lys 
1               5                   10                  15      


Trp Ala Leu Arg Phe Ser Ile Arg Pro Leu Ser Cys Ser Ser Gln Leu 
            20                  25                  30          


Arg Ala Ala Pro Ala Val Gln Thr Lys Thr Lys Lys Thr Leu Ala Lys 
        35                  40                  45              


Pro Asn Ile Arg Asn Val Val Val Val Asp Gly Val Arg Thr Pro Phe 
    50                  55                  60                  


Leu Leu Ser Gly Thr Ser Tyr Lys Asp Leu Met Pro His Asp Leu Ala 
65                  70                  75                  80  


Arg Ala Ala Leu Thr Gly Leu Leu His Arg Thr Ser Val Pro Lys Glu 
                85                  90                  95      


Val Val Asp Tyr Ile Ile Phe Gly Thr Val Ile Gln Glu Val Lys Thr 
            100                 105                 110         


Ser Asn Val Ala Arg Glu Ala Ala Leu Gly Ala Gly Phe Ser Asp Lys 
        115                 120                 125             


Thr Pro Ala His Thr Val Thr Met Ala Cys Ile Ser Ala Asn Gln Ala 
    130                 135                 140                 


Met Thr Thr Gly Lys Asp Thr Val Thr Lys Asp Asn Gly Ile Arg Pro 
145                 150                 155                 160 


Ser Ser Leu Glu Gln Met Ala Lys Leu Lys Pro Ala Phe Ile Lys Pro 
                165                 170                 175     


Tyr Gly Thr Val Thr Ala Ala Asn Ser Ser Phe Leu Thr Asp Gly Ala 
            180                 185                 190         


Ser Ala Met Leu Ile Met Ala Glu Glu Lys Ala Leu Ala Met Gly Tyr 
        195                 200                 205             


Lys Pro Lys Ala Tyr Leu Arg Asp Phe Met Tyr Val Ser Gln Asp Pro 
    210                 215                 220                 


Lys Asp Gln Leu Leu Leu Gly Pro Thr Tyr Ala Thr Pro Lys Val Leu 
225                 230                 235                 240 


Glu Lys Ala Gly Leu Thr Met Asn Asp Ile Asp Ala Phe Glu Phe His 
                245                 250                 255     


Glu Ala Phe Ser Gly Gln Ile Leu Ala Asn Phe Lys Ala Met Asp Ser 
            260                 265                 270         


Asp Trp Phe Ala Glu Asn Tyr Met Gly Arg Lys Thr Lys Val Gly Leu 
        275                 280                 285             


Pro Pro Leu Glu Lys Phe Asn Asn Trp Gly Gly Ser Leu Ser Leu Gly 
    290                 295                 300                 


His Pro Phe Gly Ala Thr Gly Cys Arg Leu Val Met Ala Ala Ala Asn 
305                 310                 315                 320 


Arg Leu Arg Lys Glu Gly Gly Gln Tyr Gly Leu Val Ala Ala Cys Ala 
                325                 330                 335     


Ala Gly Gly Gln Gly His Ala Met Ile Val Glu Ala Tyr Pro Lys 
            340                 345                 350     


<210>  6366
<211>  150
<212>  PRT
<213>  Homo Sapiens

<400>  6366

Met Thr Ile Leu Thr Tyr Pro Phe Lys Asn Leu Pro Thr Ala Ser Lys 
1               5                   10                  15      


Trp Ala Leu Arg Phe Ser Ile Arg Pro Leu Ser Cys Ser Ser Gln Leu 
            20                  25                  30          


Arg Ala Ala Pro Ala Val Gln Thr Lys Thr Lys Lys Thr Leu Ala Lys 
        35                  40                  45              


Pro Asn Ile Arg Asn Val Val Val Val Asp Gly Val Arg Thr Pro Phe 
    50                  55                  60                  


Leu Leu Ser Gly Thr Ser Tyr Lys Asp Leu Met Pro His Asp Leu Ala 
65                  70                  75                  80  


Arg Ala Ala Leu Thr Gly Leu Leu His Arg Thr Ser Val Pro Lys Glu 
                85                  90                  95      


Val Val Asp Tyr Ile Ile Phe Gly Thr Val Ile Gln Glu Val Lys Thr 
            100                 105                 110         


Ser Asn Val Ala Arg Glu Ala Ala Leu Gly Ala Gly Phe Ser Asp Lys 
        115                 120                 125             


Thr Pro Ala His Thr Val Thr Met Ala Cys Ile Ser Ala Asn Gln Ala 
    130                 135                 140                 


Met Thr Thr Gly Val Gly 
145                 150 


<210>  6367
<211>  176
<212>  PRT
<213>  Homo Sapiens

<400>  6367

Met Thr Ile Leu Thr Tyr Pro Phe Lys Asn Leu Pro Thr Ala Ser Lys 
1               5                   10                  15      


Trp Ala Leu Arg Phe Ser Ile Arg Pro Leu Ser Cys Ser Ser Gln Leu 
            20                  25                  30          


Arg Ala Ala Pro Ala Val Gln Thr Lys Thr Lys Lys Thr Leu Ala Lys 
        35                  40                  45              


Pro Asn Ile Arg Asn Val Val Val Val Asp Gly Val Arg Thr Pro Phe 
    50                  55                  60                  


Leu Leu Ser Gly Thr Ser Tyr Lys Asp Leu Met Pro His Asp Leu Ala 
65                  70                  75                  80  


Arg Ala Ala Leu Thr Gly Leu Leu His Arg Thr Ser Val Pro Lys Glu 
                85                  90                  95      


Val Val Asp Tyr Ile Ile Phe Gly Thr Val Ile Gln Glu Val Lys Thr 
            100                 105                 110         


Ser Asn Val Ala Arg Glu Ala Ala Leu Gly Ala Gly Phe Ser Asp Lys 
        115                 120                 125             


Thr Pro Ala His Thr Val Thr Met Ala Cys Ile Ser Ala Asn Gln Ala 
    130                 135                 140                 


Met Thr Thr Gly Val Gly Leu Ile Ala Ser Gly Gln Cys Asp Val Ile 
145                 150                 155                 160 


Val Ala Gly Gly Val Glu Leu Met Ser Asp Val Pro Ile Arg His Ser 
                165                 170                 175     


<210>  6368
<211>  474
<212>  PRT
<213>  Homo Sapiens

<400>  6368

Met Thr Ile Leu Thr Tyr Pro Phe Lys Asn Leu Pro Thr Ala Ser Lys 
1               5                   10                  15      


Trp Ala Leu Arg Phe Ser Ile Arg Pro Leu Ser Cys Ser Ser Gln Leu 
            20                  25                  30          


Arg Ala Ala Pro Ala Val Gln Thr Lys Thr Lys Lys Thr Leu Ala Lys 
        35                  40                  45              


Pro Asn Ile Arg Asn Val Val Val Val Asp Gly Val Arg Thr Pro Phe 
    50                  55                  60                  


Leu Leu Ser Gly Thr Ser Tyr Lys Asp Leu Met Pro His Asp Leu Ala 
65                  70                  75                  80  


Arg Ala Ala Leu Thr Gly Leu Leu His Arg Thr Ser Val Pro Lys Glu 
                85                  90                  95      


Val Val Asp Tyr Ile Ile Phe Gly Thr Val Ile Gln Glu Val Lys Thr 
            100                 105                 110         


Ser Asn Val Ala Arg Glu Ala Ala Leu Gly Ala Gly Phe Ser Asp Lys 
        115                 120                 125             


Thr Pro Ala His Thr Val Thr Met Ala Cys Ile Ser Ala Asn Gln Ala 
    130                 135                 140                 


Met Thr Thr Gly Val Gly Leu Ile Ala Ser Gly Gln Cys Asp Val Ile 
145                 150                 155                 160 


Val Ala Gly Gly Val Glu Leu Met Ser Asp Val Pro Ile Arg His Ser 
                165                 170                 175     


Arg Lys Met Arg Lys Leu Met Leu Asp Leu Asn Lys Ala Lys Ser Met 
            180                 185                 190         


Gly Gln Arg Leu Ser Leu Ile Ser Lys Phe Arg Phe Asn Phe Leu Ala 
        195                 200                 205             


Pro Glu Leu Pro Ala Val Ser Glu Phe Ser Thr Ser Glu Thr Met Gly 
    210                 215                 220                 


His Ser Ala Asp Arg Leu Ala Ala Ala Phe Ala Val Ser Arg Leu Glu 
225                 230                 235                 240 


Gln Asp Glu Tyr Ala Leu Arg Ser His Ser Leu Ala Lys Lys Ala Gln 
                245                 250                 255     


Asp Glu Gly Leu Leu Ser Asp Val Val Pro Phe Lys Val Pro Gly Lys 
            260                 265                 270         


Asp Thr Val Thr Lys Asp Asn Gly Ile Arg Pro Ser Ser Leu Glu Gln 
        275                 280                 285             


Met Ala Lys Leu Lys Pro Ala Phe Ile Lys Pro Tyr Gly Thr Val Thr 
    290                 295                 300                 


Ala Ala Asn Ser Ser Phe Leu Thr Asp Gly Ala Ser Ala Met Leu Ile 
305                 310                 315                 320 


Met Ala Glu Glu Lys Ala Leu Ala Met Gly Tyr Lys Pro Lys Ala Tyr 
                325                 330                 335     


Leu Arg Asp Phe Met Tyr Val Ser Gln Asp Pro Lys Asp Gln Leu Leu 
            340                 345                 350         


Leu Gly Pro Thr Tyr Ala Thr Pro Lys Val Leu Glu Lys Ala Gly Leu 
        355                 360                 365             


Thr Met Asn Asp Ile Asp Ala Phe Glu Phe His Glu Ala Phe Ser Gly 
    370                 375                 380                 


Gln Ile Leu Ala Asn Phe Lys Ala Met Asp Ser Asp Trp Phe Ala Glu 
385                 390                 395                 400 


Asn Tyr Met Gly Arg Lys Thr Lys Val Gly Leu Pro Pro Leu Glu Lys 
                405                 410                 415     


Phe Asn Asn Trp Gly Gly Ser Leu Ser Leu Gly His Pro Phe Gly Ala 
            420                 425                 430         


Thr Gly Cys Arg Leu Val Met Ala Ala Ala Asn Arg Leu Arg Lys Glu 
        435                 440                 445             


Gly Gly Gln Tyr Gly Leu Val Ala Ala Cys Ala Ala Gly Gly Gln Gly 
    450                 455                 460                 


His Ala Met Ile Val Glu Ala Tyr Pro Lys 
465                 470                 


<210>  6369
<211>  452
<212>  PRT
<213>  Homo Sapiens

<400>  6369

Met Thr Leu Val Ser Gly Trp Leu Leu Tyr Gly Trp Ile Ile Ala Val 
1               5                   10                  15      


Gln Thr Lys Thr Lys Lys Thr Leu Ala Lys Pro Asn Ile Arg Asn Val 
            20                  25                  30          


Val Val Val Asp Gly Val Arg Thr Pro Phe Leu Leu Ser Gly Thr Ser 
        35                  40                  45              


Tyr Lys Asp Leu Met Pro His Asp Leu Ala Arg Ala Ala Leu Thr Gly 
    50                  55                  60                  


Leu Leu His Arg Thr Ser Val Pro Lys Glu Val Val Asp Tyr Ile Ile 
65                  70                  75                  80  


Phe Gly Thr Val Ile Gln Glu Val Lys Thr Ser Asn Val Ala Arg Glu 
                85                  90                  95      


Ala Ala Leu Gly Ala Gly Phe Ser Asp Lys Thr Pro Ala His Thr Val 
            100                 105                 110         


Thr Met Ala Cys Ile Ser Ala Asn Gln Ala Met Thr Thr Gly Val Gly 
        115                 120                 125             


Leu Ile Ala Ser Gly Gln Cys Asp Val Ile Val Ala Gly Gly Val Glu 
    130                 135                 140                 


Leu Met Ser Asp Val Pro Ile Arg His Ser Arg Lys Met Arg Lys Leu 
145                 150                 155                 160 


Met Leu Asp Leu Asn Lys Ala Lys Ser Met Gly Gln Arg Leu Ser Leu 
                165                 170                 175     


Ile Ser Lys Phe Arg Phe Asn Phe Leu Ala Pro Glu Leu Pro Ala Val 
            180                 185                 190         


Ser Glu Phe Ser Thr Ser Glu Thr Met Gly His Ser Ala Asp Arg Leu 
        195                 200                 205             


Ala Ala Ala Phe Ala Val Ser Arg Leu Glu Gln Asp Glu Tyr Ala Leu 
    210                 215                 220                 


Arg Ser His Ser Leu Ala Lys Lys Ala Gln Asp Glu Gly Leu Leu Ser 
225                 230                 235                 240 


Asp Val Val Pro Phe Lys Val Pro Gly Lys Asp Thr Val Thr Lys Asp 
                245                 250                 255     


Asn Gly Ile Arg Pro Ser Ser Leu Glu Gln Met Ala Lys Leu Lys Pro 
            260                 265                 270         


Ala Phe Ile Lys Pro Tyr Gly Thr Val Thr Ala Ala Asn Ser Ser Phe 
        275                 280                 285             


Leu Thr Asp Gly Ala Ser Ala Met Leu Ile Met Ala Glu Glu Lys Ala 
    290                 295                 300                 


Leu Ala Met Gly Tyr Lys Pro Lys Ala Tyr Leu Arg Asp Phe Met Tyr 
305                 310                 315                 320 


Val Ser Gln Asp Pro Lys Asp Gln Leu Leu Leu Gly Pro Thr Tyr Ala 
                325                 330                 335     


Thr Pro Lys Val Leu Glu Lys Ala Gly Leu Thr Met Asn Asp Ile Asp 
            340                 345                 350         


Ala Phe Glu Phe His Glu Ala Phe Ser Gly Gln Ile Leu Ala Asn Phe 
        355                 360                 365             


Lys Ala Met Asp Ser Asp Trp Phe Ala Glu Asn Tyr Met Gly Arg Lys 
    370                 375                 380                 


Thr Lys Val Gly Leu Pro Pro Leu Glu Lys Phe Asn Asn Trp Gly Gly 
385                 390                 395                 400 


Ser Leu Ser Leu Gly His Pro Phe Gly Ala Thr Gly Cys Arg Leu Val 
                405                 410                 415     


Met Ala Ala Ala Asn Arg Leu Arg Lys Glu Gly Gly Gln Tyr Gly Leu 
            420                 425                 430         


Val Ala Ala Cys Ala Ala Gly Gly Gln Gly His Ala Met Ile Val Glu 
        435                 440                 445             


Ala Tyr Pro Lys 
    450         


<210>  6370
<211>  84
<212>  PRT
<213>  Homo Sapiens

<400>  6370

Met Ala Leu Ser Ser Gln Ile Trp Ala Ala Cys Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ala Ser Leu Thr Ser Gly Ser Val Phe Pro Gln Gln Thr Gly 
            20                  25                  30          


Gln Leu Ala Glu Leu Gln Pro Gln Asp Arg Ala Gly Ala Arg Ala Ser 
        35                  40                  45              


Trp Met Pro Met Phe Gln Arg Arg Arg Arg Arg Asp Thr His Phe Pro 
    50                  55                  60                  


Ile Cys Ile Phe Cys Cys Gly Cys Cys His Arg Ser Lys Cys Gly Met 
65                  70                  75                  80  


Cys Cys Lys Thr 
                


<210>  6371
<211>  84
<212>  PRT
<213>  Homo Sapiens

<400>  6371

Met Ala Leu Ser Ser Gln Ile Trp Ala Ala Cys Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ala Ser Leu Thr Ser Gly Ser Val Phe Pro Gln Gln Thr Gly 
            20                  25                  30          


Gln Leu Ala Glu Leu Gln Pro Gln Asp Arg Ala Gly Ala Arg Ala Ser 
        35                  40                  45              


Trp Met Pro Met Phe Gln Arg Arg Arg Arg Arg Asp Thr His Phe Pro 
    50                  55                  60                  


Ile Cys Ile Phe Cys Cys Gly Cys Cys His Arg Ser Lys Cys Gly Met 
65                  70                  75                  80  


Cys Cys Lys Thr 
                


<210>  6372
<211>  153
<212>  PRT
<213>  Homo Sapiens

<400>  6372

Met Lys Ser Leu Leu Leu Leu Val Leu Ile Ser Ile Cys Trp Ala Asp 
1               5                   10                  15      


His Leu Ser Asp Asn Tyr Thr Leu Asp His Asp Arg Ala Ile His Ile 
            20                  25                  30          


Gln Ala Glu Asn Gly Pro His Leu Leu Val Glu Ala Glu Gln Ala Lys 
        35                  40                  45              


Val Phe Ser His Arg Gly Gly Asn Val Thr Leu Pro Cys Lys Phe Tyr 
    50                  55                  60                  


Arg Asp Pro Thr Ala Phe Gly Ser Gly Ile His Lys Ile Arg Ile Lys 
65                  70                  75                  80  


Trp Thr Lys Leu Thr Ser Asp Tyr Leu Lys Glu Val Asp Val Phe Val 
                85                  90                  95      


Ser Met Gly Tyr His Lys Lys Thr Tyr Gly Gly Tyr Gln Gly Arg Val 
            100                 105                 110         


Phe Leu Lys Gly Gly Ser Asp Ser Asp Ala Ser Leu Val Ile Thr Asp 
        115                 120                 125             


Leu Thr Leu Glu Asp Tyr Gly Arg Tyr Lys Cys Glu Val Ile Glu Gly 
    130                 135                 140                 


Leu Glu Asp Asp Thr Val Val Val Ala 
145                 150             


<210>  6373
<211>  161
<212>  PRT
<213>  Homo Sapiens

<400>  6373

Met Lys Ser Leu Leu Leu Leu Val Leu Ile Ser Ile Cys Trp Ala Asp 
1               5                   10                  15      


His Leu Ser Asp Asn Tyr Thr Leu Asp His Asp Arg Ala Ile His Ile 
            20                  25                  30          


Gln Ala Glu Asn Gly Pro His Leu Leu Val Glu Ala Glu Gln Ala Lys 
        35                  40                  45              


Val Phe Ser His Arg Gly Gly Asn Val Thr Leu Pro Cys Lys Phe Tyr 
    50                  55                  60                  


Arg Asp Pro Thr Ala Phe Gly Ser Gly Ile His Lys Ile Arg Ile Lys 
65                  70                  75                  80  


Trp Thr Lys Leu Thr Ser Asp Tyr Leu Lys Glu Val Asp Val Phe Val 
                85                  90                  95      


Ser Met Gly Tyr His Lys Lys Thr Tyr Gly Gly Tyr Gln Gly Arg Val 
            100                 105                 110         


Phe Leu Lys Gly Gly Ser Asp Ser Asp Ala Ser Leu Val Ile Thr Asp 
        115                 120                 125             


Leu Thr Leu Glu Asp Tyr Gly Arg Tyr Lys Cys Glu Val Ile Glu Gly 
    130                 135                 140                 


Leu Glu Asp Asp Thr Val Val Val Ala Leu Asp Leu Gln Gly Met Tyr 
145                 150                 155                 160 


Leu 
    


<210>  6374
<211>  169
<212>  PRT
<213>  Homo Sapiens

<400>  6374

Met Lys Ser Leu Leu Leu Leu Val Leu Ile Ser Ile Cys Trp Ala Asp 
1               5                   10                  15      


His Leu Ser Asp Asn Tyr Thr Leu Asp His Asp Arg Ala Ile His Ile 
            20                  25                  30          


Gln Ala Glu Asn Gly Pro His Leu Leu Val Glu Ala Glu Gln Ala Lys 
        35                  40                  45              


Val Phe Ser His Arg Gly Gly Asn Val Thr Leu Pro Cys Lys Phe Tyr 
    50                  55                  60                  


Arg Asp Pro Thr Ala Phe Gly Ser Gly Ile His Lys Ile Arg Ile Lys 
65                  70                  75                  80  


Trp Thr Lys Leu Thr Ser Asp Tyr Leu Lys Glu Val Asp Val Phe Val 
                85                  90                  95      


Ser Met Gly Tyr His Lys Lys Thr Tyr Gly Gly Tyr Gln Gly Arg Val 
            100                 105                 110         


Phe Leu Lys Gly Gly Ser Asp Ser Asp Ala Ser Leu Val Ile Thr Asp 
        115                 120                 125             


Leu Thr Leu Glu Asp Tyr Gly Arg Tyr Lys Cys Glu Val Ile Glu Gly 
    130                 135                 140                 


Leu Glu Asp Asp Thr Val Val Val Ala Leu Asp Leu Gln Gly Val Val 
145                 150                 155                 160 


Phe Pro Tyr Phe Pro Arg Leu Gly Arg 
                165                 


<210>  6375
<211>  199
<212>  PRT
<213>  Homo Sapiens

<400>  6375

Met Lys Ser Leu Leu Leu Leu Val Leu Ile Ser Ile Cys Trp Ala Asp 
1               5                   10                  15      


His Leu Ser Asp Asn Tyr Thr Leu Asp His Asp Arg Ala Ile His Ile 
            20                  25                  30          


Gln Ala Glu Asn Gly Pro His Leu Leu Val Glu Ala Glu Gln Ala Lys 
        35                  40                  45              


Val Phe Ser His Arg Gly Gly Asn Val Thr Leu Pro Cys Lys Phe Tyr 
    50                  55                  60                  


Arg Asp Pro Thr Ala Phe Gly Ser Gly Ile His Lys Ile Arg Ile Lys 
65                  70                  75                  80  


Trp Thr Lys Leu Thr Ser Asp Tyr Leu Lys Glu Val Asp Val Phe Val 
                85                  90                  95      


Ser Met Gly Tyr His Lys Lys Thr Tyr Gly Gly Tyr Gln Gly Arg Val 
            100                 105                 110         


Phe Leu Lys Gly Gly Ser Asp Ser Asp Ala Ser Leu Val Ile Thr Asp 
        115                 120                 125             


Leu Thr Leu Glu Asp Tyr Gly Arg Tyr Lys Cys Glu Val Ile Glu Gly 
    130                 135                 140                 


Leu Glu Asp Asp Thr Val Val Val Ala Leu Asp Leu Gln Gly Val Val 
145                 150                 155                 160 


Phe Pro Tyr Phe Pro Arg Leu Gly Arg Tyr Asn Leu Asn Phe His Glu 
                165                 170                 175     


Ala Gln Gln Ala Cys Leu Asp Gln Asp Ala Val Ile Ala Ser Phe Asp 
            180                 185                 190         


Gln Leu Tyr Asp Ala Trp Arg 
        195                 


<210>  6376
<211>  354
<212>  PRT
<213>  Homo Sapiens

<400>  6376

Met Lys Ser Leu Leu Leu Leu Val Leu Ile Ser Ile Cys Trp Ala Asp 
1               5                   10                  15      


His Leu Ser Asp Asn Tyr Thr Leu Asp His Asp Arg Ala Ile His Ile 
            20                  25                  30          


Gln Ala Glu Asn Gly Pro His Leu Leu Val Glu Ala Glu Gln Ala Lys 
        35                  40                  45              


Val Phe Ser His Arg Gly Gly Asn Val Thr Leu Pro Cys Lys Phe Tyr 
    50                  55                  60                  


Arg Asp Pro Thr Ala Phe Gly Ser Gly Ile His Lys Ile Arg Ile Lys 
65                  70                  75                  80  


Trp Thr Lys Leu Thr Ser Asp Tyr Leu Lys Glu Val Asp Val Phe Val 
                85                  90                  95      


Ser Met Gly Tyr His Lys Lys Thr Tyr Gly Gly Tyr Gln Gly Arg Val 
            100                 105                 110         


Phe Leu Lys Gly Gly Ser Asp Ser Asp Ala Ser Leu Val Ile Thr Asp 
        115                 120                 125             


Leu Thr Leu Glu Asp Tyr Gly Arg Tyr Lys Cys Glu Val Ile Glu Gly 
    130                 135                 140                 


Leu Glu Asp Asp Thr Val Val Val Ala Leu Asp Leu Gln Gly Val Val 
145                 150                 155                 160 


Phe Pro Tyr Phe Pro Arg Leu Gly Arg Tyr Asn Leu Asn Phe His Glu 
                165                 170                 175     


Ala Gln Gln Ala Cys Leu Asp Gln Asp Ala Val Ile Ala Ser Phe Asp 
            180                 185                 190         


Gln Leu Tyr Asp Ala Trp Arg Gly Gly Leu Asp Trp Cys Asn Ala Gly 
        195                 200                 205             


Trp Leu Ser Asp Gly Ser Val Gln Tyr Pro Ile Thr Lys Pro Arg Glu 
    210                 215                 220                 


Pro Cys Gly Gly Gln Asn Thr Val Pro Gly Val Arg Asn Tyr Gly Phe 
225                 230                 235                 240 


Trp Asp Lys Asp Lys Ser Arg Tyr Asp Val Phe Cys Phe Thr Ser Asn 
                245                 250                 255     


Phe Asn Gly Arg Phe Tyr Tyr Leu Ile His Pro Thr Lys Leu Thr Tyr 
            260                 265                 270         


Asp Glu Ala Val Gln Ala Cys Leu Asn Asp Gly Ala Gln Ile Ala Lys 
        275                 280                 285             


Val Gly Gln Ile Phe Ala Ala Trp Lys Ile Leu Gly Tyr Asp Arg Cys 
    290                 295                 300                 


Asp Ala Gly Trp Leu Ala Asp Gly Ser Val Arg Tyr Pro Ile Ser Arg 
305                 310                 315                 320 


Pro Arg Arg Arg Cys Ser Pro Thr Glu Ala Ala Val Arg Phe Val Gly 
                325                 330                 335     


Phe Pro Asp Lys Lys His Lys Leu Tyr Gly Val Tyr Cys Phe Arg Ala 
            340                 345                 350         


Tyr Asn 
        


<210>  6377
<211>  258
<212>  PRT
<213>  Homo Sapiens

<400>  6377

Met Lys Ser Leu Leu Leu Leu Val Leu Ile Ser Ile Cys Trp Ala Asp 
1               5                   10                  15      


His Leu Ser Asp Asn Tyr Thr Leu Asp His Asp Arg Ala Ile His Ile 
            20                  25                  30          


Gln Ala Glu Asn Gly Pro His Leu Leu Val Glu Ala Glu Gln Ala Lys 
        35                  40                  45              


Val Phe Ser His Arg Gly Gly Asn Val Thr Leu Pro Cys Lys Phe Tyr 
    50                  55                  60                  


Arg Asp Pro Thr Ala Phe Gly Ser Gly Ile His Lys Ile Arg Ile Lys 
65                  70                  75                  80  


Trp Thr Lys Leu Thr Ser Asp Tyr Leu Lys Glu Val Asp Val Phe Val 
                85                  90                  95      


Ser Met Gly Tyr His Lys Lys Thr Tyr Gly Gly Tyr Gln Gly Arg Val 
            100                 105                 110         


Phe Leu Lys Gly Gly Ser Asp Ser Asp Ala Ser Leu Val Ile Thr Asp 
        115                 120                 125             


Leu Thr Leu Glu Asp Tyr Gly Arg Tyr Lys Cys Glu Val Ile Glu Gly 
    130                 135                 140                 


Leu Glu Asp Asp Thr Val Val Val Ala Leu Asp Leu Gln Gly Val Val 
145                 150                 155                 160 


Phe Pro Tyr Phe Pro Arg Leu Gly Arg Tyr Asn Leu Asn Phe His Glu 
                165                 170                 175     


Ala Gln Gln Ala Cys Leu Asp Gln Asp Ala Val Ile Ala Ser Phe Asp 
            180                 185                 190         


Gln Leu Tyr Asp Ala Trp Arg Gly Gly Leu Asp Trp Cys Asn Ala Gly 
        195                 200                 205             


Trp Leu Ser Asp Gly Ser Val Gln Tyr Pro Ile Thr Lys Pro Arg Glu 
    210                 215                 220                 


Pro Cys Gly Gly Gln Asn Thr Val Pro Gly Val Arg Asn Tyr Gly Phe 
225                 230                 235                 240 


Trp Asp Lys Asp Lys Ser Arg Tyr Asp Val Phe Cys Phe Thr Ser Asn 
                245                 250                 255     


Phe Asn 
        


<210>  6378
<211>  182
<212>  PRT
<213>  Homo Sapiens

<400>  6378

Met Lys Ser Leu Leu Leu Leu Val Leu Ile Ser Ile Cys Trp Ala Asp 
1               5                   10                  15      


His Leu Ser Asp Asn Tyr Thr Leu Asp His Asp Arg Ala Ile His Ile 
            20                  25                  30          


Gln Glu Asn Gly Pro His Leu Leu Val Glu Ala Glu Gln Ala Lys Val 
        35                  40                  45              


Phe Ser His Arg Gly Gly Asn Val Thr Leu Pro Cys Lys Phe Tyr Arg 
    50                  55                  60                  


Asp Pro Thr Ala Phe Gly Ser Gly Ile His Lys Ile Arg Ile Lys Trp 
65                  70                  75                  80  


Thr Lys Leu Thr Ser Asp Tyr Leu Lys Glu Val Asp Val Phe Val Ser 
                85                  90                  95      


Met Gly Tyr His Lys Lys Thr Tyr Gly Gly Tyr Gln Gly Arg Val Phe 
            100                 105                 110         


Leu Lys Gly Gly Ser Asp Ser Asp Ala Ser Leu Val Ile Thr Asp Leu 
        115                 120                 125             


Thr Leu Glu Asp Tyr Gly Arg Tyr Lys Cys Glu Val Ile Glu Gly Leu 
    130                 135                 140                 


Glu Asp Asp Thr Val Val Val Ala Leu Asp Leu Gln Gly Val Val Phe 
145                 150                 155                 160 


Pro Tyr Phe Pro Arg Leu Gly Arg Tyr Asn Leu Asn Phe His Glu Ala 
                165                 170                 175     


Gln Gln Ala Cys Leu Asp 
            180         


<210>  6379
<211>  185
<212>  PRT
<213>  Homo Sapiens

<400>  6379

Met Pro Gly Trp Leu Thr Leu Pro Thr Leu Cys Arg Phe Leu Leu Trp 
1               5                   10                  15      


Ala Phe Thr Ile Phe His Lys Ala Gln Gly Asp Pro Ala Ser His Pro 
            20                  25                  30          


Gly Pro His Tyr Leu Leu Pro Pro Ile His Glu Val Ile His Ser His 
        35                  40                  45              


Arg Gly Ala Thr Ala Thr Leu Pro Cys Val Leu Gly Thr Thr Pro Pro 
    50                  55                  60                  


Ser Tyr Lys Val Arg Trp Ser Lys Val Glu Pro Gly Glu Leu Arg Glu 
65                  70                  75                  80  


Thr Leu Ile Leu Ile Thr Asn Gly Leu His Ala Arg Gly Tyr Gly Pro 
                85                  90                  95      


Leu Gly Gly Arg Ala Arg Met Arg Arg Gly His Arg Leu Asp Ala Ser 
            100                 105                 110         


Leu Val Ile Ala Gly Val Arg Leu Glu Asp Glu Gly Arg Tyr Arg Cys 
        115                 120                 125             


Glu Leu Ile Asn Gly Ile Glu Asp Glu Ser Val Ala Leu Thr Leu Ser 
    130                 135                 140                 


Leu Glu Gly Val Val Phe Pro Tyr Gln Pro Ser Arg Gly Arg Tyr Gln 
145                 150                 155                 160 


Phe Asn Tyr Tyr Glu Ala Lys Gln Ala Cys Glu Glu Gln Asp Gly Arg 
                165                 170                 175     


Leu Ala Thr Tyr Ser Gln Leu Tyr Gln 
            180                 185 


<210>  6380
<211>  340
<212>  PRT
<213>  Homo Sapiens

<400>  6380

Met Pro Gly Trp Leu Thr Leu Pro Thr Leu Cys Arg Phe Leu Leu Trp 
1               5                   10                  15      


Ala Phe Thr Ile Phe His Lys Ala Gln Gly Asp Pro Ala Ser His Pro 
            20                  25                  30          


Gly Pro His Tyr Leu Leu Pro Pro Ile His Glu Val Ile His Ser His 
        35                  40                  45              


Arg Gly Ala Thr Ala Thr Leu Pro Cys Val Leu Gly Thr Thr Pro Pro 
    50                  55                  60                  


Ser Tyr Lys Val Arg Trp Ser Lys Val Glu Pro Gly Glu Leu Arg Glu 
65                  70                  75                  80  


Thr Leu Ile Leu Ile Thr Asn Gly Leu His Ala Arg Gly Tyr Gly Pro 
                85                  90                  95      


Leu Gly Gly Arg Ala Arg Met Arg Arg Gly His Arg Leu Asp Ala Ser 
            100                 105                 110         


Leu Val Ile Ala Gly Val Arg Leu Glu Asp Glu Gly Arg Tyr Arg Cys 
        115                 120                 125             


Glu Leu Ile Asn Gly Ile Glu Asp Glu Ser Val Ala Leu Thr Leu Ser 
    130                 135                 140                 


Leu Glu Gly Val Val Phe Pro Tyr Gln Pro Ser Arg Gly Arg Tyr Gln 
145                 150                 155                 160 


Phe Asn Tyr Tyr Glu Ala Lys Gln Ala Cys Glu Glu Gln Asp Gly Arg 
                165                 170                 175     


Leu Ala Thr Tyr Ser Gln Leu Tyr Gln Ala Trp Thr Glu Gly Leu Asp 
            180                 185                 190         


Trp Cys Asn Ala Gly Trp Leu Leu Glu Gly Ser Val Arg Tyr Pro Val 
        195                 200                 205             


Leu Thr Ala Arg Ala Pro Cys Gly Gly Arg Gly Arg Pro Gly Ile Arg 
    210                 215                 220                 


Ser Tyr Gly Pro Arg Asp Arg Met Arg Asp Arg Tyr Asp Ala Phe Cys 
225                 230                 235                 240 


Phe Thr Ser Ala Leu Ala Gly Gln Val Phe Phe Val Pro Gly Arg Leu 
                245                 250                 255     


Thr Leu Ser Glu Ala His Ala Ala Cys Arg Arg Arg Gly Ala Val Val 
            260                 265                 270         


Ala Lys Val Gly His Leu Tyr Ala Ala Trp Lys Phe Ser Gly Leu Asp 
        275                 280                 285             


Gln Cys Asp Gly Gly Trp Leu Ala Asp Gly Ser Val Arg Phe Pro Ile 
    290                 295                 300                 


Thr Thr Pro Arg Pro Arg Cys Gly Gly Leu Pro Asp Pro Gly Val Arg 
305                 310                 315                 320 


Ser Phe Gly Phe Pro Arg Pro Gln Gln Ala Ala Tyr Gly Thr Tyr Cys 
                325                 330                 335     


Tyr Ala Glu Asn 
            340 


<210>  6381
<211>  226
<212>  PRT
<213>  Homo Sapiens

<400>  6381

Met Gly Leu Leu Leu Leu Val Pro Leu Leu Leu Leu Pro Gly Ser Tyr 
1               5                   10                  15      


Gly Leu Pro Phe Tyr Asn Gly Phe Tyr Tyr Ser Asn Ser Ala Asn Asp 
            20                  25                  30          


Gln Asn Leu Gly Asn Gly His Gly Lys Asp Leu Leu Asn Gly Val Lys 
        35                  40                  45              


Leu Val Val Glu Thr Pro Glu Glu Thr Leu Phe Thr Tyr Gln Gly Ala 
    50                  55                  60                  


Ser Val Ile Leu Pro Cys Arg Tyr Arg Tyr Glu Pro Ala Leu Val Ser 
65                  70                  75                  80  


Pro Arg Arg Val Arg Val Lys Trp Trp Lys Leu Ser Glu Asn Gly Ala 
                85                  90                  95      


Pro Glu Lys Asp Val Leu Val Ala Ile Gly Leu Arg His Arg Ser Phe 
            100                 105                 110         


Gly Asp Tyr Gln Gly Arg Val His Leu Arg Gln Asp Lys Glu His Asp 
        115                 120                 125             


Val Ser Leu Glu Ile Gln Asp Leu Arg Leu Glu Asp Tyr Gly Arg Tyr 
    130                 135                 140                 


Arg Cys Glu Val Ile Asp Gly Leu Glu Asp Glu Ser Gly Leu Val Glu 
145                 150                 155                 160 


Leu Glu Leu Arg Ala Glu Ser Gln Glu Arg Gly Gly Asn Gly Gln Glu 
                165                 170                 175     


Val Trp Ser Phe Leu Thr Ser Pro Pro Thr Gly Ala Thr Ser Ser Thr 
            180                 185                 190         


Ser Thr Arg Ala Ser Arg Ser Val Gln Ser Arg Leu Arg Trp Trp Pro 
        195                 200                 205             


Pro Leu Ser Ser Ser Ser Gly Pro Gly Arg Arg Ala Trp Thr Gly Ala 
    210                 215                 220                 


Thr Arg 
225     


<210>  6382
<211>  360
<212>  PRT
<213>  Homo Sapiens

<400>  6382

Met Gly Leu Leu Leu Leu Val Pro Leu Leu Leu Leu Pro Gly Ser Tyr 
1               5                   10                  15      


Gly Leu Pro Phe Tyr Asn Gly Phe Tyr Tyr Ser Asn Ser Ala Asn Asp 
            20                  25                  30          


Gln Asn Leu Gly Asn Gly His Gly Lys Asp Leu Leu Asn Gly Val Lys 
        35                  40                  45              


Leu Val Val Glu Thr Pro Glu Glu Thr Leu Phe Thr Tyr Gln Gly Ala 
    50                  55                  60                  


Ser Val Ile Leu Pro Cys Arg Tyr Arg Tyr Glu Pro Ala Leu Val Ser 
65                  70                  75                  80  


Pro Arg Arg Val Arg Val Lys Trp Trp Lys Leu Ser Glu Asn Gly Ala 
                85                  90                  95      


Pro Glu Lys Asp Val Leu Val Ala Ile Gly Leu Arg His Arg Ser Phe 
            100                 105                 110         


Gly Asp Tyr Gln Gly Arg Val His Leu Arg Gln Asp Lys Glu His Asp 
        115                 120                 125             


Val Ser Leu Glu Ile Gln Asp Leu Arg Leu Glu Asp Tyr Gly Arg Tyr 
    130                 135                 140                 


Arg Cys Glu Val Ile Asp Gly Leu Glu Asp Glu Ser Gly Leu Val Glu 
145                 150                 155                 160 


Leu Glu Leu Arg Gly Val Val Phe Pro Tyr Gln Ser Pro Asn Gly Arg 
                165                 170                 175     


Tyr Gln Phe Asn Phe His Glu Gly Gln Gln Val Cys Ala Glu Gln Ala 
            180                 185                 190         


Ala Val Val Ala Ser Phe Glu Gln Leu Phe Arg Ala Trp Glu Glu Gly 
        195                 200                 205             


Leu Asp Trp Cys Asn Ala Gly Trp Leu Gln Asp Ala Thr Val Gln Tyr 
    210                 215                 220                 


Pro Ile Met Leu Pro Arg Gln Pro Cys Gly Gly Pro Gly Leu Ala Pro 
225                 230                 235                 240 


Gly Val Arg Ser Tyr Gly Pro Arg His Arg Arg Leu His Arg Tyr Asp 
                245                 250                 255     


Val Phe Cys Phe Ala Thr Ala Leu Lys Gly Arg Val Tyr Tyr Leu Glu 
            260                 265                 270         


His Pro Glu Lys Leu Thr Leu Thr Glu Ala Arg Glu Ala Cys Gln Glu 
        275                 280                 285             


Asp Asp Ala Thr Ile Ala Lys Val Gly Gln Leu Phe Ala Ala Trp Lys 
    290                 295                 300                 


Phe His Gly Leu Asp Arg Cys Asp Ala Gly Trp Leu Ala Asp Gly Ser 
305                 310                 315                 320 


Val Arg Tyr Pro Val Val His Pro His Pro Asn Cys Gly Pro Pro Glu 
                325                 330                 335     


Pro Gly Val Arg Ser Phe Gly Phe Pro Asp Pro Gln Ser Arg Leu Tyr 
            340                 345                 350         


Gly Val Tyr Cys Tyr Arg Gln His 
        355                 360 


<210>  6383
<211>  186
<212>  PRT
<213>  Homo Sapiens

<400>  6383

Met Gly Leu Leu Leu Leu Val Pro Leu Leu Leu Leu Pro Gly Ser Tyr 
1               5                   10                  15      


Gly Leu Pro Phe Tyr Asn Gly Phe Tyr Tyr Ser Asn Ser Ala Asn Asp 
            20                  25                  30          


Gln Asn Leu Gly Asn Gly His Gly Lys Asp Leu Leu Asn Gly Val Lys 
        35                  40                  45              


Leu Val Val Glu Thr Pro Glu Glu Thr Leu Phe Thr Tyr Gln Gly Ala 
    50                  55                  60                  


Ser Val Ile Leu Pro Cys Arg Tyr Arg Tyr Glu Pro Ala Leu Val Ser 
65                  70                  75                  80  


Pro Arg Arg Val Arg Val Lys Trp Trp Lys Leu Ser Glu Asn Gly Ala 
                85                  90                  95      


Pro Glu Lys Asp Val Leu Val Ala Ile Gly Leu Arg His Arg Ser Phe 
            100                 105                 110         


Gly Asp Tyr Gln Gly Arg Val His Leu Arg Gln Asp Lys Glu His Asp 
        115                 120                 125             


Val Ser Leu Glu Ile Gln Asp Leu Arg Leu Glu Asp Tyr Gly Arg Tyr 
    130                 135                 140                 


Arg Cys Glu Val Ile Asp Gly Leu Glu Asp Glu Ser Gly Leu Val Glu 
145                 150                 155                 160 


Leu Glu Leu Arg Gly Trp Gly Cys Val Ser Ser His Leu Ser His Met 
                165                 170                 175     


Leu Gly Arg Gln Phe Gly Asp Arg Gly Arg 
            180                 185     


<210>  6384
<211>  422
<212>  PRT
<213>  Homo Sapiens

<400>  6384

Met Arg Lys Trp Arg His Arg Glu Val Asn Leu Pro Glu Val Thr Gln 
1               5                   10                  15      


Gln Asp Ala Val Cys Pro Ala Pro Ile Pro Ser Pro Gly Leu Ser Ala 
            20                  25                  30          


Gln Thr Gly Leu Gln Lys Ile Trp Gly Thr Ile His Cys Gln Val Cys 
        35                  40                  45              


Pro Gly Ala Pro Ala Trp Pro Gly Ser Pro Trp His Glu Glu Met Gly 
    50                  55                  60                  


Leu Leu Leu Leu Val Pro Leu Leu Leu Leu Pro Gly Ser Tyr Gly Leu 
65                  70                  75                  80  


Pro Phe Tyr Asn Gly Phe Tyr Tyr Ser Asn Ser Ala Asn Asp Gln Asn 
                85                  90                  95      


Leu Gly Asn Gly His Gly Lys Asp Leu Leu Asn Gly Val Lys Leu Val 
            100                 105                 110         


Val Glu Thr Pro Glu Glu Thr Leu Phe Thr Tyr Gln Gly Ala Ser Val 
        115                 120                 125             


Ile Leu Pro Cys Arg Tyr Arg Tyr Glu Pro Ala Leu Val Ser Pro Arg 
    130                 135                 140                 


Arg Val Arg Val Lys Trp Trp Lys Leu Ser Glu Asn Gly Ala Pro Glu 
145                 150                 155                 160 


Lys Asp Val Leu Val Ala Ile Gly Leu Arg His Arg Ser Phe Gly Asp 
                165                 170                 175     


Tyr Gln Gly Arg Val His Leu Arg Gln Asp Lys Glu His Asp Val Ser 
            180                 185                 190         


Leu Glu Ile Gln Asp Leu Arg Leu Glu Asp Tyr Gly Arg Tyr Arg Cys 
        195                 200                 205             


Glu Val Ile Asp Gly Leu Glu Asp Glu Ser Gly Leu Val Glu Leu Glu 
    210                 215                 220                 


Leu Arg Gly Val Val Phe Pro Tyr Gln Ser Pro Asn Gly Arg Tyr Gln 
225                 230                 235                 240 


Phe Asn Phe His Glu Gly Gln Gln Val Cys Ala Glu Gln Ala Ala Val 
                245                 250                 255     


Val Ala Ser Phe Glu Gln Leu Phe Arg Ala Trp Glu Glu Gly Leu Asp 
            260                 265                 270         


Trp Cys Asn Ala Gly Trp Leu Gln Asp Ala Thr Val Gln Tyr Pro Ile 
        275                 280                 285             


Met Leu Pro Arg Gln Pro Cys Gly Gly Pro Gly Leu Ala Pro Gly Val 
    290                 295                 300                 


Arg Ser Tyr Gly Pro Arg His Arg Arg Leu His Arg Tyr Asp Val Phe 
305                 310                 315                 320 


Cys Phe Ala Thr Ala Leu Lys Gly Arg Val Tyr Tyr Leu Glu His Pro 
                325                 330                 335     


Glu Lys Leu Thr Leu Thr Glu Ala Arg Glu Ala Cys Gln Glu Asp Asp 
            340                 345                 350         


Ala Thr Ile Ala Lys Val Gly Gln Leu Phe Ala Ala Trp Lys Phe His 
        355                 360                 365             


Gly Leu Asp Arg Cys Asp Ala Gly Trp Leu Ala Asp Gly Ser Val Arg 
    370                 375                 380                 


Tyr Pro Val Val His Pro His Pro Asn Cys Gly Pro Pro Glu Pro Gly 
385                 390                 395                 400 


Val Arg Ser Phe Gly Phe Pro Asp Pro Gln Ser Arg Leu Tyr Gly Val 
                405                 410                 415     


Tyr Cys Tyr Arg Gln His 
            420         


<210>  6385
<211>  402
<212>  PRT
<213>  Homo Sapiens

<400>  6385

Met Val Cys Ala Arg Ala Ala Leu Gly Pro Gly Ala Leu Trp Ala Ala 
1               5                   10                  15      


Ala Trp Gly Val Leu Leu Leu Thr Ala Pro Ala Gly Ala Gln Arg Gly 
            20                  25                  30          


Arg Lys Lys Val Val His Val Leu Glu Gly Glu Ser Gly Ser Val Val 
        35                  40                  45              


Val Gln Thr Ala Pro Gly Gln Val Val Ser His Arg Gly Gly Thr Ile 
    50                  55                  60                  


Val Leu Pro Cys Arg Tyr His Tyr Glu Ala Ala Ala His Gly His Asp 
65                  70                  75                  80  


Gly Val Arg Leu Lys Trp Thr Lys Val Val Asp Pro Leu Ala Phe Thr 
                85                  90                  95      


Asp Val Phe Val Ala Leu Gly Pro Gln His Arg Ala Phe Gly Ser Tyr 
            100                 105                 110         


Arg Gly Arg Ala Glu Leu Gln Gly Asp Gly Pro Gly Asp Ala Ser Leu 
        115                 120                 125             


Val Leu Arg Asn Val Thr Leu Gln Asp Tyr Gly Arg Tyr Glu Cys Glu 
    130                 135                 140                 


Val Thr Asn Glu Leu Glu Asp Asp Ala Gly Met Val Lys Leu Asp Leu 
145                 150                 155                 160 


Glu Gly Val Val Phe Pro Tyr His Pro Arg Gly Gly Arg Tyr Lys Leu 
                165                 170                 175     


Thr Phe Ala Glu Ala Gln Arg Ala Cys Ala Glu Gln Asp Gly Ile Leu 
            180                 185                 190         


Ala Ser Ala Glu Gln Leu His Ala Ala Trp Arg Asp Gly Leu Asp Trp 
        195                 200                 205             


Cys Asn Ala Gly Trp Leu Arg Asp Gly Ser Val Gln Tyr Pro Val Asn 
    210                 215                 220                 


Arg Pro Arg Glu Pro Cys Gly Gly Leu Gly Gly Thr Gly Ser Ala Gly 
225                 230                 235                 240 


Gly Gly Gly Asp Ala Asn Gly Gly Leu Arg Asn Tyr Gly Tyr Arg His 
                245                 250                 255     


Asn Ala Glu Glu Arg Tyr Asp Ala Phe Cys Phe Thr Ser Asn Leu Pro 
            260                 265                 270         


Gly Arg Val Phe Phe Leu Lys Pro Leu Arg Pro Val Pro Phe Ser Gly 
        275                 280                 285             


Ala Ala Arg Ala Cys Ala Ala Arg Gly Ala Ala Val Ala Lys Val Gly 
    290                 295                 300                 


Gln Leu Phe Ala Ala Trp Lys Leu Gln Leu Leu Asp Arg Cys Thr Ala 
305                 310                 315                 320 


Gly Trp Leu Ala Asp Gly Ser Ala Arg Tyr Pro Ile Val Asn Pro Arg 
                325                 330                 335     


Ala Arg Cys Gly Gly Arg Arg Pro Gly Val Arg Ser Leu Gly Phe Pro 
            340                 345                 350         


Asp Ala Thr Arg Arg Leu Phe Gly Val Tyr Cys Tyr Arg Ala Pro Gly 
        355                 360                 365             


Ala Pro Asp Pro Ala Pro Gly Gly Trp Gly Trp Gly Trp Ala Gly Gly 
    370                 375                 380                 


Gly Gly Trp Ala Gly Gly Ala Arg Asp Pro Ala Ala Trp Thr Pro Leu 
385                 390                 395                 400 


His Val 
        


<210>  6386
<211>  334
<212>  PRT
<213>  Homo Sapiens

<400>  6386

Met Pro Leu Leu Gly Leu Leu Pro Arg Arg Ala Trp Ala Ser Leu Leu 
1               5                   10                  15      


Ser Gln Leu Leu Arg Pro Pro Cys Ala Ser Cys Thr Gly Ala Val Arg 
            20                  25                  30          


Cys Gln Ser Gln Asp Phe Asp Ile Ala Gly Gln Phe Asp Pro Met Ile 
        35                  40                  45              


Pro Asp Ala Glu Cys Leu Lys Ile Met Cys Glu Ile Leu Ser Gly Leu 
    50                  55                  60                  


Gln Leu Gly Asp Phe Leu Ile Lys Met Ala Trp Lys Asp Val Arg His 
65                  70                  75                  80  


Glu Met Val Val Lys Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile 
                85                  90                  95      


Gly Asp Tyr Val Gln Cys His Gly Gly Val Ser Leu Val Glu Gln Met 
            100                 105                 110         


Phe Gln Asp Pro Arg Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu 
        115                 120                 125             


Gly Asp Leu Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Ala 
    130                 135                 140                 


Asp Lys Ile Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr 
145                 150                 155                 160 


Thr Gly Val Ile Tyr Glu Ala Val Leu Leu Gln Thr Pro Thr Gln Ala 
                165                 170                 175     


Gly Glu Glu Pro Leu Asn Val Gly Ser Val Ala Ala Gly Gly Arg Tyr 
            180                 185                 190         


Asp Gly Leu Val Gly Met Phe Asp Pro Lys Gly His Lys Val Pro Cys 
        195                 200                 205             


Val Gly Leu Ser Ile Gly Val Glu Arg Ile Phe Tyr Ile Val Glu Gln 
    210                 215                 220                 


Arg Met Lys Thr Lys Gly Glu Lys Val Arg Thr Thr Glu Thr Gln Val 
225                 230                 235                 240 


Phe Val Ala Thr Pro Gln Lys Asn Phe Leu Gln Glu Arg Leu Lys Leu 
                245                 250                 255     


Ile Ala Glu Leu Trp Asp Ser Gly Ile Lys Ala Glu Met Leu Tyr Lys 
            260                 265                 270         


Asn Asn Pro Lys Leu Leu Thr Gln Leu His Tyr Cys Glu Ser Thr Gly 
        275                 280                 285             


Ile Pro Leu Val Val Ile Ile Gly Glu Gln Glu Leu Lys Glu Gly Val 
    290                 295                 300                 


Ile Lys Ile Arg Ser Val Ala Ser Arg Glu Glu Val Ala Ile Lys Arg 
305                 310                 315                 320 


Glu Asn Phe Val Ala Glu Ile Gln Lys Arg Leu Ser Glu Ser 
                325                 330                 


<210>  6387
<211>  512
<212>  PRT
<213>  Homo Sapiens

<400>  6387

Met Pro Leu Leu Gly Leu Leu Pro Arg Arg Ala Trp Ala Ser Leu Leu 
1               5                   10                  15      


Ser Gln Leu Leu Arg Pro Pro Cys Ala Ser Cys Thr Gly Ala Val Arg 
            20                  25                  30          


Cys Gln Ser Gln Gly Glu Glu Ser Leu Gln Val Ala Glu Ala Val Leu 
        35                  40                  45              


Thr Ser Gln Leu Lys Ala His Gln Glu Lys Pro Asn Phe Ile Ile Lys 
    50                  55                  60                  


Thr Pro Lys Gly Thr Arg Asp Leu Ser Pro Gln His Met Val Val Arg 
65                  70                  75                  80  


Glu Lys Ile Leu Asp Leu Val Ile Ser Cys Phe Lys Arg His Gly Ala 
                85                  90                  95      


Lys Gly Met Asp Thr Pro Ala Phe Glu Leu Lys Glu Thr Leu Thr Glu 
            100                 105                 110         


Lys Tyr Gly Glu Asp Ser Gly Leu Met Tyr Asp Leu Lys Asp Gln Gly 
        115                 120                 125             


Gly Glu Leu Leu Ser Leu Arg Tyr Asp Leu Thr Val Pro Phe Ala Arg 
    130                 135                 140                 


Tyr Leu Ala Met Asn Lys Val Lys Lys Met Lys Arg Tyr His Val Gly 
145                 150                 155                 160 


Lys Val Trp Arg Arg Glu Ser Pro Thr Ile Val Gln Gly Arg Tyr Arg 
                165                 170                 175     


Glu Phe Cys Gln Cys Asp Phe Asp Ile Ala Gly Gln Phe Asp Pro Met 
            180                 185                 190         


Ile Pro Asp Ala Glu Cys Leu Lys Ile Met Cys Glu Ile Leu Ser Gly 
        195                 200                 205             


Leu Gln Leu Gly Asp Phe Leu Ile Lys Val Asn Asp Arg Arg Ile Val 
    210                 215                 220                 


Asp Gly Met Phe Ala Val Cys Gly Val Pro Glu Ser Lys Phe Arg Ala 
225                 230                 235                 240 


Ile Cys Ser Ser Ile Asp Lys Leu Asp Lys Met Ala Trp Lys Asp Val 
                245                 250                 255     


Arg His Glu Met Val Val Lys Lys Gly Leu Ala Pro Glu Val Ala Asp 
            260                 265                 270         


Arg Ile Gly Asp Tyr Val Gln Cys His Gly Gly Val Ser Leu Val Glu 
        275                 280                 285             


Gln Met Phe Gln Asp Pro Arg Leu Ser Gln Asn Lys Gln Ala Leu Glu 
    290                 295                 300                 


Gly Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe Gly 
305                 310                 315                 320 


Ile Ala Asp Lys Ile Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp 
                325                 330                 335     


Tyr Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu Leu Gln Thr Pro Thr 
            340                 345                 350         


Gln Ala Gly Glu Glu Pro Leu Asn Val Gly Ser Val Ala Ala Gly Gly 
        355                 360                 365             


Arg Tyr Asp Gly Leu Val Gly Met Phe Asp Pro Lys Gly His Lys Val 
    370                 375                 380                 


Pro Cys Val Gly Leu Ser Ile Gly Val Glu Arg Ile Phe Tyr Ile Val 
385                 390                 395                 400 


Glu Gln Arg Met Lys Thr Lys Gly Glu Lys Val Arg Thr Thr Glu Thr 
                405                 410                 415     


Gln Val Phe Val Ala Thr Pro Gln Lys Asn Phe Leu Gln Glu Arg Leu 
            420                 425                 430         


Lys Leu Ile Ala Glu Leu Trp Asp Ser Gly Ile Lys Ala Glu Met Leu 
        435                 440                 445             


Tyr Lys Asn Asn Pro Lys Leu Leu Thr Gln Leu His Tyr Cys Glu Ser 
    450                 455                 460                 


Thr Gly Ile Pro Leu Val Val Ile Ile Gly Glu Gln Glu Leu Lys Glu 
465                 470                 475                 480 


Gly Val Ile Lys Ile Arg Ser Val Ala Ser Arg Glu Glu Val Ala Ile 
                485                 490                 495     


Lys Arg Glu Asn Phe Val Ala Glu Ile Gln Lys Arg Leu Ser Glu Ser 
            500                 505                 510         


<210>  6388
<211>  512
<212>  PRT
<213>  Homo Sapiens

<400>  6388

Met Pro Leu Leu Gly Leu Leu Pro Arg Arg Ala Trp Ala Ser Leu Leu 
1               5                   10                  15      


Ser Gln Leu Leu Arg Pro Pro Cys Ala Ser Cys Thr Gly Ala Val Arg 
            20                  25                  30          


Cys Gln Ser Gln Gly Glu Glu Ser Leu Gln Val Ala Glu Ala Val Leu 
        35                  40                  45              


Thr Ser Gln Leu Lys Ala His Gln Glu Lys Pro Asn Phe Ile Ile Lys 
    50                  55                  60                  


Thr Pro Lys Gly Thr Arg Asp Leu Ser Pro Gln His Met Val Val Arg 
65                  70                  75                  80  


Glu Lys Ile Leu Asp Leu Val Ile Ser Cys Phe Lys Arg His Gly Ala 
                85                  90                  95      


Lys Gly Met Asp Thr Pro Ala Phe Glu Leu Lys Glu Thr Leu Thr Glu 
            100                 105                 110         


Lys Tyr Gly Glu Asp Ser Gly Leu Met Tyr Asp Leu Lys Asp Gln Gly 
        115                 120                 125             


Gly Glu Leu Leu Ser Leu Arg Tyr Asp Leu Thr Val Pro Phe Ala Arg 
    130                 135                 140                 


Tyr Leu Ala Met Asn Lys Val Lys Lys Met Lys Arg Tyr His Val Gly 
145                 150                 155                 160 


Lys Val Trp Arg Arg Glu Ser Pro Thr Ile Val Gln Gly Arg Tyr Arg 
                165                 170                 175     


Glu Phe Cys Gln Cys Asp Phe Asp Ile Ala Gly Gln Phe Asp Pro Met 
            180                 185                 190         


Ile Pro Asp Ala Glu Cys Leu Lys Ile Met Cys Glu Ile Leu Ser Gly 
        195                 200                 205             


Leu Gln Leu Gly Asp Phe Leu Ile Lys Val Asn Asp Arg Arg Ile Val 
    210                 215                 220                 


Asp Gly Met Phe Ala Val Cys Gly Val Pro Glu Ser Lys Phe Arg Ala 
225                 230                 235                 240 


Ile Cys Ser Ser Ile Asp Lys Leu Asp Lys Met Ala Trp Lys Asp Val 
                245                 250                 255     


Arg His Glu Met Val Val Lys Lys Gly Leu Ala Pro Glu Val Ala Asp 
            260                 265                 270         


Arg Ile Gly Asp Tyr Val Gln Cys His Gly Gly Val Ser Leu Val Glu 
        275                 280                 285             


Gln Met Phe Gln Asp Pro Arg Leu Ser Gln Asn Lys Gln Ala Leu Glu 
    290                 295                 300                 


Gly Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe Gly 
305                 310                 315                 320 


Ile Ala Asp Lys Ile Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp 
                325                 330                 335     


Tyr Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu Leu Gln Thr Pro Thr 
            340                 345                 350         


Gln Ala Gly Glu Glu Pro Leu Asn Val Gly Ser Val Ala Ala Gly Gly 
        355                 360                 365             


Arg Tyr Asp Gly Leu Val Gly Met Phe Asp Pro Lys Gly His Lys Val 
    370                 375                 380                 


Pro Cys Val Gly Leu Ser Ile Gly Val Glu Arg Ile Phe Tyr Ile Val 
385                 390                 395                 400 


Glu Gln Arg Met Lys Thr Lys Gly Glu Lys Val Arg Thr Thr Glu Thr 
                405                 410                 415     


Gln Val Phe Val Ala Thr Pro Gln Lys Asn Phe Leu Gln Glu Arg Leu 
            420                 425                 430         


Lys Leu Ile Ala Glu Leu Trp Asp Ser Gly Ile Lys Ala Glu Met Leu 
        435                 440                 445             


Tyr Lys Asn Asn Pro Lys Leu Leu Thr Gln Leu His Tyr Cys Glu Ser 
    450                 455                 460                 


Thr Gly Ile Pro Leu Val Val Ile Ile Gly Glu Gln Glu Leu Lys Glu 
465                 470                 475                 480 


Gly Val Ile Lys Ile Arg Ser Val Ala Ser Arg Glu Glu Val Ala Ile 
                485                 490                 495     


Lys Arg Glu Asn Phe Val Ala Glu Ile Gln Lys Arg Leu Ser Glu Ser 
            500                 505                 510         


<210>  6389
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  6389

Met Pro Leu Leu Gly Leu Leu Pro Arg Arg Ala Trp Ala Ser Leu Leu 
1               5                   10                  15      


Ser Gln Leu Leu Arg Pro Pro Cys Ala Ser Cys Thr Gly Ala Val Arg 
            20                  25                  30          


Cys Gln Ser Gln Gly Glu Glu Ser Leu Gln Val Gly Gly Gln Gln Gly 
        35                  40                  45              


Gln Arg Cys His Arg Ser Gly Gln Cys Pro Glu Lys Pro His Leu Thr 
    50                  55                  60                  


Phe Ile Leu Leu Pro Gly Cys Arg Gly Ser Val Asn Ile Pro Thr Glu 
65                  70                  75                  80  


Ser Thr Ser Arg Glu Thr Lys Phe Tyr Tyr Gln Asp Pro Lys Gly Tyr 
                85                  90                  95      


Gln Gly Ser 
            


<210>  6390
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  6390

Met Pro Leu Leu Gly Leu Leu Pro Arg Arg Ala Trp Ala Ser Leu Leu 
1               5                   10                  15      


Ser Gln Leu Leu Arg Pro Pro Cys Ala Ser Cys Thr Gly Ala Val Arg 
            20                  25                  30          


Cys Gln Ser Gln Gly Glu Glu Ser Leu Gln Val Gly Gly Gln Gln Gly 
        35                  40                  45              


Gln Arg Cys His Arg Ser Gly Gln Cys Pro Glu Lys Pro His Leu Thr 
    50                  55                  60                  


Phe Ile Leu Leu Pro Gly Cys Arg Gly Ser Val Asn Ile Pro Thr Glu 
65                  70                  75                  80  


Ser Thr Ser Arg Glu Thr Lys Phe Tyr Tyr Gln Asp Pro Lys Gly Tyr 
                85                  90                  95      


Gln Gly Ser 
            


<210>  6391
<211>  481
<212>  PRT
<213>  Homo Sapiens

<400>  6391

Met Pro Leu Leu Gly Leu Leu Pro Arg Arg Ala Trp Ala Ser Leu Leu 
1               5                   10                  15      


Ser Gln Leu Leu Arg Pro Pro Cys Ala Ser Cys Thr Gly Ala Val Arg 
            20                  25                  30          


Cys Gln Ser Gln Gly Thr Arg Asp Leu Ser Pro Gln His Met Val Val 
        35                  40                  45              


Arg Glu Lys Ile Leu Asp Leu Val Ile Ser Cys Phe Lys Arg His Gly 
    50                  55                  60                  


Ala Lys Gly Met Asp Thr Pro Ala Phe Glu Leu Lys Glu Thr Leu Thr 
65                  70                  75                  80  


Glu Lys Tyr Gly Glu Asp Ser Gly Leu Met Tyr Asp Leu Lys Asp Gln 
                85                  90                  95      


Gly Gly Glu Leu Leu Ser Leu Arg Tyr Asp Leu Thr Val Pro Phe Ala 
            100                 105                 110         


Arg Tyr Leu Ala Met Asn Lys Val Lys Lys Met Lys Arg Tyr His Val 
        115                 120                 125             


Gly Lys Val Trp Arg Arg Glu Ser Pro Thr Ile Val Gln Gly Arg Tyr 
    130                 135                 140                 


Arg Glu Phe Cys Gln Cys Asp Phe Asp Ile Ala Gly Gln Phe Asp Pro 
145                 150                 155                 160 


Met Ile Pro Asp Ala Glu Cys Leu Lys Ile Met Cys Glu Ile Leu Ser 
                165                 170                 175     


Gly Leu Gln Leu Gly Asp Phe Leu Ile Lys Val Asn Asp Arg Arg Ile 
            180                 185                 190         


Val Asp Gly Met Phe Ala Val Cys Gly Val Pro Glu Ser Lys Phe Arg 
        195                 200                 205             


Ala Ile Cys Ser Ser Ile Asp Lys Leu Asp Lys Met Ala Trp Lys Asp 
    210                 215                 220                 


Val Arg His Glu Met Val Val Lys Lys Gly Leu Ala Pro Glu Val Ala 
225                 230                 235                 240 


Asp Arg Ile Gly Asp Tyr Val Gln Cys His Gly Gly Val Ser Leu Val 
                245                 250                 255     


Glu Gln Met Phe Gln Asp Pro Arg Leu Ser Gln Asn Lys Gln Ala Leu 
            260                 265                 270         


Glu Gly Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe 
        275                 280                 285             


Gly Ile Ala Asp Lys Ile Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu 
    290                 295                 300                 


Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu Leu Gln Thr Pro 
305                 310                 315                 320 


Thr Gln Ala Gly Glu Glu Pro Leu Asn Val Gly Ser Val Ala Ala Gly 
                325                 330                 335     


Gly Arg Tyr Asp Gly Leu Val Gly Met Phe Asp Pro Lys Gly His Lys 
            340                 345                 350         


Val Pro Cys Val Gly Leu Ser Ile Gly Val Glu Arg Ile Phe Tyr Ile 
        355                 360                 365             


Val Glu Gln Arg Met Lys Thr Lys Gly Glu Lys Val Arg Thr Thr Glu 
    370                 375                 380                 


Thr Gln Val Phe Val Ala Thr Pro Gln Lys Asn Phe Leu Gln Glu Arg 
385                 390                 395                 400 


Leu Lys Leu Ile Ala Glu Leu Trp Asp Ser Gly Ile Lys Ala Glu Met 
                405                 410                 415     


Leu Tyr Lys Asn Asn Pro Lys Leu Leu Thr Gln Leu His Tyr Cys Glu 
            420                 425                 430         


Ser Thr Gly Ile Pro Leu Val Val Ile Ile Gly Glu Gln Glu Leu Lys 
        435                 440                 445             


Glu Gly Val Ile Lys Ile Arg Ser Val Ala Ser Arg Glu Glu Val Ala 
    450                 455                 460                 


Ile Lys Arg Glu Asn Phe Val Ala Glu Ile Gln Lys Arg Leu Ser Glu 
465                 470                 475                 480 


Ser 
    


<210>  6392
<211>  399
<212>  PRT
<213>  Homo Sapiens

<400>  6392

Met Pro Leu Leu Gly Leu Leu Pro Arg Arg Ala Trp Ala Ser Leu Leu 
1               5                   10                  15      


Ser Gln Leu Leu Arg Pro Pro Cys Ala Ser Cys Thr Gly Ala Val Arg 
            20                  25                  30          


Cys Gln Ser Gln Val Ala Glu Ala Val Leu Thr Ser Gln Leu Lys Ala 
        35                  40                  45              


His Gln Glu Lys Pro Asn Phe Ile Ile Lys Thr Pro Lys Gly Thr Arg 
    50                  55                  60                  


Asp Leu Ser Pro Gln His Met Val Val Arg Glu Lys Ile Leu Asp Leu 
65                  70                  75                  80  


Val Ile Ser Cys Phe Lys Arg His Gly Ala Lys Gly Met Asp Thr Pro 
                85                  90                  95      


Ala Phe Glu Leu Lys Asp Phe Asp Ile Ala Gly Gln Phe Asp Pro Met 
            100                 105                 110         


Ile Pro Asp Ala Glu Cys Leu Lys Ile Met Cys Glu Ile Leu Ser Gly 
        115                 120                 125             


Leu Gln Leu Gly Asp Phe Leu Ile Lys Met Ala Trp Lys Asp Val Arg 
    130                 135                 140                 


His Glu Met Val Val Lys Lys Gly Leu Ala Pro Glu Val Ala Asp Arg 
145                 150                 155                 160 


Ile Gly Asp Tyr Val Gln Cys His Gly Gly Val Ser Leu Val Glu Gln 
                165                 170                 175     


Met Phe Gln Asp Pro Arg Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly 
            180                 185                 190         


Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile 
        195                 200                 205             


Ala Asp Lys Ile Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr 
    210                 215                 220                 


Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu Leu Gln Thr Pro Thr Gln 
225                 230                 235                 240 


Ala Gly Glu Glu Pro Leu Asn Val Gly Ser Val Ala Ala Gly Gly Arg 
                245                 250                 255     


Tyr Asp Gly Leu Val Gly Met Phe Asp Pro Lys Gly His Lys Val Pro 
            260                 265                 270         


Cys Val Gly Leu Ser Ile Gly Val Glu Arg Ile Phe Tyr Ile Val Glu 
        275                 280                 285             


Gln Arg Met Lys Thr Lys Gly Glu Lys Val Arg Thr Thr Glu Thr Gln 
    290                 295                 300                 


Val Phe Val Ala Thr Pro Gln Lys Asn Phe Leu Gln Glu Arg Leu Lys 
305                 310                 315                 320 


Leu Ile Ala Glu Leu Trp Asp Ser Gly Ile Lys Ala Glu Met Leu Tyr 
                325                 330                 335     


Lys Asn Asn Pro Lys Leu Leu Thr Gln Leu His Tyr Cys Glu Ser Thr 
            340                 345                 350         


Gly Ile Pro Leu Val Val Ile Ile Gly Glu Gln Glu Leu Lys Glu Gly 
        355                 360                 365             


Val Ile Lys Ile Arg Ser Val Ala Ser Arg Glu Glu Val Ala Ile Lys 
    370                 375                 380                 


Arg Glu Asn Phe Val Ala Glu Ile Gln Lys Arg Leu Ser Glu Ser 
385                 390                 395                 


<210>  6393
<211>  473
<212>  PRT
<213>  Homo Sapiens

<400>  6393

Met Pro Leu Leu Gly Leu Leu Pro Arg Arg Ala Trp Ala Ser Leu Leu 
1               5                   10                  15      


Ser Gln Leu Leu Arg Pro Pro Cys Ala Ser Cys Thr Gly Ala Val Arg 
            20                  25                  30          


Cys Gln Ser Gln Val Ala Glu Ala Val Leu Thr Ser Gln Leu Lys Ala 
        35                  40                  45              


His Gln Glu Lys Pro Asn Phe Ile Ile Lys Thr Pro Lys Gly Thr Arg 
    50                  55                  60                  


Asp Leu Ser Pro Gln His Met Val Val Arg Glu Lys Ile Leu Asp Leu 
65                  70                  75                  80  


Val Ile Ser Cys Phe Lys Arg His Gly Ala Lys Gly Met Asp Thr Pro 
                85                  90                  95      


Ala Phe Glu Leu Lys Glu Thr Leu Thr Glu Lys Tyr Gly Glu Asp Ser 
            100                 105                 110         


Gly Leu Met Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu 
        115                 120                 125             


Arg Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys 
    130                 135                 140                 


Val Lys Lys Met Lys Arg Tyr His Val Gly Lys Val Trp Arg Arg Glu 
145                 150                 155                 160 


Ser Pro Thr Ile Val Gln Gly Arg Tyr Arg Glu Phe Cys Gln Cys Asp 
                165                 170                 175     


Phe Asp Ile Ala Gly Gln Phe Asp Pro Met Ile Pro Asp Ala Glu Cys 
            180                 185                 190         


Leu Lys Ile Met Cys Glu Ile Leu Ser Gly Leu Gln Leu Gly Asp Phe 
        195                 200                 205             


Leu Ile Lys Met Ala Trp Lys Asp Val Arg His Glu Met Val Val Lys 
    210                 215                 220                 


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
225                 230                 235                 240 


Cys His Gly Gly Val Ser Leu Val Glu Gln Met Phe Gln Asp Pro Arg 
                245                 250                 255     


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
            260                 265                 270         


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Ala Asp Lys Ile Ser Phe 
        275                 280                 285             


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
    290                 295                 300                 


Glu Ala Val Leu Leu Gln Thr Pro Thr Gln Ala Gly Glu Glu Pro Leu 
305                 310                 315                 320 


Asn Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
                325                 330                 335     


Met Phe Asp Pro Lys Gly His Lys Val Pro Cys Val Gly Leu Ser Ile 
            340                 345                 350         


Gly Val Glu Arg Ile Phe Tyr Ile Val Glu Gln Arg Met Lys Thr Lys 
        355                 360                 365             


Gly Glu Lys Val Arg Thr Thr Glu Thr Gln Val Phe Val Ala Thr Pro 
    370                 375                 380                 


Gln Lys Asn Phe Leu Gln Glu Arg Leu Lys Leu Ile Ala Glu Leu Trp 
385                 390                 395                 400 


Asp Ser Gly Ile Lys Ala Glu Met Leu Tyr Lys Asn Asn Pro Lys Leu 
                405                 410                 415     


Leu Thr Gln Leu His Tyr Cys Glu Ser Thr Gly Ile Pro Leu Val Val 
            420                 425                 430         


Ile Ile Gly Glu Gln Glu Leu Lys Glu Gly Val Ile Lys Ile Arg Ser 
        435                 440                 445             


Val Ala Ser Arg Glu Glu Val Ala Ile Lys Arg Glu Asn Phe Val Ala 
    450                 455                 460                 


Glu Ile Gln Lys Arg Leu Ser Glu Ser 
465                 470             


<210>  6394
<211>  506
<212>  PRT
<213>  Homo Sapiens

<400>  6394

Met Pro Leu Leu Gly Leu Leu Pro Arg Arg Ala Trp Ala Ser Leu Leu 
1               5                   10                  15      


Ser Gln Leu Leu Arg Pro Pro Cys Ala Ser Cys Thr Gly Ala Val Arg 
            20                  25                  30          


Cys Gln Ser Gln Val Ala Glu Ala Val Leu Thr Ser Gln Leu Lys Ala 
        35                  40                  45              


His Gln Glu Lys Pro Asn Phe Ile Ile Lys Thr Pro Lys Gly Thr Arg 
    50                  55                  60                  


Asp Leu Ser Pro Gln His Met Val Val Arg Glu Lys Ile Leu Asp Leu 
65                  70                  75                  80  


Val Ile Ser Cys Phe Lys Arg His Gly Ala Lys Gly Met Asp Thr Pro 
                85                  90                  95      


Ala Phe Glu Leu Lys Glu Thr Leu Thr Glu Lys Tyr Gly Glu Asp Ser 
            100                 105                 110         


Gly Leu Met Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu 
        115                 120                 125             


Arg Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys 
    130                 135                 140                 


Val Lys Lys Met Lys Arg Tyr His Val Gly Lys Val Trp Arg Arg Glu 
145                 150                 155                 160 


Ser Pro Thr Ile Val Gln Gly Arg Tyr Arg Glu Phe Cys Gln Cys Asp 
                165                 170                 175     


Phe Asp Ile Ala Gly Gln Phe Asp Pro Met Ile Pro Asp Ala Glu Cys 
            180                 185                 190         


Leu Lys Ile Met Cys Glu Ile Leu Ser Gly Leu Gln Leu Gly Asp Phe 
        195                 200                 205             


Leu Ile Lys Val Asn Asp Arg Arg Ile Val Asp Gly Met Phe Ala Val 
    210                 215                 220                 


Cys Gly Val Pro Glu Ser Lys Phe Arg Ala Ile Cys Ser Ser Ile Asp 
225                 230                 235                 240 


Lys Leu Asp Lys Met Ala Trp Lys Asp Val Arg His Glu Met Val Val 
                245                 250                 255     


Lys Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val 
            260                 265                 270         


Gln Cys His Gly Gly Val Ser Leu Val Glu Gln Met Phe Gln Asp Pro 
        275                 280                 285             


Arg Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys 
    290                 295                 300                 


Leu Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Ala Asp Lys Ile Ser 
305                 310                 315                 320 


Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile 
                325                 330                 335     


Tyr Glu Ala Val Leu Leu Gln Thr Pro Thr Gln Ala Gly Glu Glu Pro 
            340                 345                 350         


Leu Asn Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val 
        355                 360                 365             


Gly Met Phe Asp Pro Lys Gly His Lys Val Pro Cys Val Gly Leu Ser 
    370                 375                 380                 


Ile Gly Val Glu Arg Ile Phe Tyr Ile Val Glu Gln Arg Met Lys Thr 
385                 390                 395                 400 


Lys Gly Glu Lys Val Arg Thr Thr Glu Thr Gln Val Phe Val Ala Thr 
                405                 410                 415     


Pro Gln Lys Asn Phe Leu Gln Glu Arg Leu Lys Leu Ile Ala Glu Leu 
            420                 425                 430         


Trp Asp Ser Gly Ile Lys Ala Glu Met Leu Tyr Lys Asn Asn Pro Lys 
        435                 440                 445             


Leu Leu Thr Gln Leu His Tyr Cys Glu Ser Thr Gly Ile Pro Leu Val 
    450                 455                 460                 


Val Ile Ile Gly Glu Gln Glu Leu Lys Glu Gly Val Ile Lys Ile Arg 
465                 470                 475                 480 


Ser Val Ala Ser Arg Glu Glu Val Ala Ile Lys Arg Glu Asn Phe Val 
                485                 490                 495     


Ala Glu Ile Gln Lys Arg Leu Ser Glu Ser 
            500                 505     


<210>  6395
<211>  506
<212>  PRT
<213>  Homo Sapiens

<400>  6395

Met Pro Leu Leu Gly Leu Leu Pro Arg Arg Ala Trp Ala Ser Leu Leu 
1               5                   10                  15      


Ser Gln Leu Leu Arg Pro Pro Cys Ala Ser Cys Thr Gly Ala Val Arg 
            20                  25                  30          


Cys Gln Ser Gln Val Ala Glu Ala Val Leu Thr Ser Gln Leu Lys Ala 
        35                  40                  45              


His Gln Glu Lys Pro Asn Phe Ile Ile Lys Thr Pro Lys Gly Thr Arg 
    50                  55                  60                  


Asp Leu Ser Pro Gln His Met Val Val Arg Glu Lys Ile Leu Asp Leu 
65                  70                  75                  80  


Val Ile Ser Cys Phe Lys Arg His Gly Ala Lys Gly Met Asp Thr Pro 
                85                  90                  95      


Ala Phe Glu Leu Lys Glu Thr Leu Thr Glu Lys Tyr Gly Glu Asp Ser 
            100                 105                 110         


Gly Leu Met Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu 
        115                 120                 125             


Arg Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys 
    130                 135                 140                 


Val Lys Lys Met Lys Arg Tyr His Val Gly Lys Val Trp Arg Arg Glu 
145                 150                 155                 160 


Ser Pro Thr Ile Val Gln Gly Arg Tyr Arg Glu Phe Cys Gln Cys Asp 
                165                 170                 175     


Phe Asp Ile Ala Gly Gln Phe Asp Pro Met Ile Pro Asp Ala Glu Cys 
            180                 185                 190         


Leu Lys Ile Met Cys Glu Ile Leu Ser Gly Leu Gln Leu Gly Asp Phe 
        195                 200                 205             


Leu Ile Lys Val Asn Asp Arg Arg Ile Val Asp Gly Met Phe Ala Val 
    210                 215                 220                 


Cys Gly Val Pro Glu Ser Lys Phe Arg Ala Ile Cys Ser Ser Ile Asp 
225                 230                 235                 240 


Lys Leu Asp Lys Met Ala Trp Lys Asp Val Arg His Glu Met Val Val 
                245                 250                 255     


Lys Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val 
            260                 265                 270         


Gln Cys His Gly Gly Val Ser Leu Val Glu Gln Met Phe Gln Asp Pro 
        275                 280                 285             


Arg Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys 
    290                 295                 300                 


Leu Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Ala Asp Lys Ile Ser 
305                 310                 315                 320 


Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile 
                325                 330                 335     


Tyr Glu Ala Val Leu Leu Gln Thr Pro Thr Gln Ala Gly Glu Glu Pro 
            340                 345                 350         


Leu Asn Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val 
        355                 360                 365             


Gly Met Phe Asp Pro Lys Gly His Lys Val Pro Cys Val Gly Leu Ser 
    370                 375                 380                 


Ile Gly Val Glu Arg Ile Phe Tyr Ile Val Glu Gln Arg Met Lys Thr 
385                 390                 395                 400 


Lys Gly Glu Lys Val Arg Thr Thr Glu Thr Gln Val Phe Val Ala Thr 
                405                 410                 415     


Pro Gln Lys Asn Phe Leu Gln Glu Arg Leu Lys Leu Ile Ala Glu Leu 
            420                 425                 430         


Trp Asp Ser Gly Ile Lys Ala Glu Met Leu Tyr Lys Asn Asn Pro Lys 
        435                 440                 445             


Leu Leu Thr Gln Leu His Tyr Cys Glu Ser Thr Gly Ile Pro Leu Val 
    450                 455                 460                 


Val Ile Ile Gly Glu Gln Glu Leu Lys Glu Gly Val Ile Lys Ile Arg 
465                 470                 475                 480 


Ser Val Ala Ser Arg Glu Glu Val Ala Ile Lys Arg Glu Asn Phe Val 
                485                 490                 495     


Ala Glu Ile Gln Lys Arg Leu Ser Glu Ser 
            500                 505     


<210>  6396
<211>  506
<212>  PRT
<213>  Homo Sapiens

<400>  6396

Met Pro Leu Leu Gly Leu Leu Pro Arg Arg Ala Trp Ala Ser Leu Leu 
1               5                   10                  15      


Ser Gln Leu Leu Arg Pro Pro Cys Ala Ser Cys Thr Gly Ala Val Arg 
            20                  25                  30          


Cys Gln Ser Gln Val Ala Glu Ala Val Leu Thr Ser Gln Leu Lys Ala 
        35                  40                  45              


His Gln Glu Lys Pro Asn Phe Ile Ile Lys Thr Pro Lys Gly Thr Arg 
    50                  55                  60                  


Asp Leu Ser Pro Gln His Met Val Val Arg Glu Lys Ile Leu Asp Leu 
65                  70                  75                  80  


Val Ile Ser Cys Phe Lys Arg His Gly Ala Lys Gly Met Asp Thr Pro 
                85                  90                  95      


Ala Phe Glu Leu Lys Glu Thr Leu Thr Glu Lys Tyr Gly Glu Asp Ser 
            100                 105                 110         


Gly Leu Met Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu 
        115                 120                 125             


Arg Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys 
    130                 135                 140                 


Val Lys Lys Met Lys Arg Tyr His Val Gly Lys Val Trp Arg Arg Glu 
145                 150                 155                 160 


Ser Pro Thr Ile Val Gln Gly Arg Tyr Arg Glu Phe Cys Gln Cys Asp 
                165                 170                 175     


Phe Asp Ile Ala Gly Gln Phe Asp Pro Met Ile Pro Asp Ala Glu Cys 
            180                 185                 190         


Leu Lys Ile Met Cys Glu Ile Leu Ser Gly Leu Gln Leu Gly Asp Phe 
        195                 200                 205             


Leu Ile Lys Val Asn Asp Arg Arg Ile Val Asp Gly Met Phe Ala Val 
    210                 215                 220                 


Cys Gly Val Pro Glu Ser Lys Phe Arg Ala Ile Cys Ser Ser Ile Asp 
225                 230                 235                 240 


Lys Leu Asp Lys Met Ala Trp Lys Asp Val Arg His Glu Met Val Val 
                245                 250                 255     


Lys Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val 
            260                 265                 270         


Gln Cys His Gly Gly Val Ser Leu Val Glu Gln Met Phe Gln Asp Pro 
        275                 280                 285             


Arg Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys 
    290                 295                 300                 


Leu Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Ala Asp Lys Ile Ser 
305                 310                 315                 320 


Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile 
                325                 330                 335     


Tyr Glu Ala Val Leu Leu Gln Thr Pro Thr Gln Ala Gly Glu Glu Pro 
            340                 345                 350         


Leu Asn Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val 
        355                 360                 365             


Gly Met Phe Asp Pro Lys Gly His Lys Val Pro Cys Val Gly Leu Ser 
    370                 375                 380                 


Ile Gly Val Glu Arg Ile Phe Tyr Ile Val Glu Gln Arg Met Lys Thr 
385                 390                 395                 400 


Lys Gly Glu Lys Val Arg Thr Thr Glu Thr Gln Val Phe Val Ala Thr 
                405                 410                 415     


Pro Gln Lys Asn Phe Leu Gln Glu Arg Leu Lys Leu Ile Ala Glu Leu 
            420                 425                 430         


Trp Asp Ser Gly Ile Lys Ala Glu Met Leu Tyr Lys Asn Asn Pro Lys 
        435                 440                 445             


Leu Leu Thr Gln Leu His Tyr Cys Glu Ser Thr Gly Ile Pro Leu Val 
    450                 455                 460                 


Val Ile Ile Gly Glu Gln Glu Leu Lys Glu Gly Val Ile Lys Ile Arg 
465                 470                 475                 480 


Ser Val Ala Ser Arg Glu Glu Val Ala Ile Lys Arg Glu Asn Phe Val 
                485                 490                 495     


Ala Glu Ile Gln Lys Arg Leu Ser Glu Ser 
            500                 505     


<210>  6397
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  6397

Met Val Val Arg Glu Lys Ile Leu Asp Leu Val Ile Ser Cys Phe Lys 
1               5                   10                  15      


Arg His Gly Ala Lys Gly Met Asp Thr Pro Ala Phe Glu Leu Lys Glu 
            20                  25                  30          


Thr Leu Thr Glu Lys Tyr Gly Glu Asp Ser Gly Leu Met Tyr Asp Leu 
        35                  40                  45              


Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg Tyr Asp Leu Thr Val 
    50                  55                  60                  


Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Val Lys Lys Met Lys Arg 
65                  70                  75                  80  


Tyr His Val Gly Lys Val Trp Arg Arg Glu Ser Pro Thr Ile Val Gln 
                85                  90                  95      


Gly Arg Tyr Arg Glu Phe Cys Gln Cys Asp Phe Asp Ile Ala Gly Gln 
            100                 105                 110         


Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu Lys Ile Met Cys Glu 
        115                 120                 125             


Ile Leu Ser Gly Leu Gln Leu Gly Asp Phe Leu Ile Lys Glu Ser Arg 
    130                 135                 140                 


Tyr Cys His Cys Phe Glu Trp Lys Gly Ile Asp Lys His Leu Gly His 
145                 150                 155                 160 


<210>  6398
<211>  436
<212>  PRT
<213>  Homo Sapiens

<400>  6398

Met Val Val Arg Glu Lys Ile Leu Asp Leu Val Ile Ser Cys Phe Lys 
1               5                   10                  15      


Arg His Gly Ala Lys Gly Met Asp Thr Pro Ala Phe Glu Leu Lys Glu 
            20                  25                  30          


Thr Leu Thr Glu Lys Tyr Gly Glu Asp Ser Gly Leu Met Tyr Asp Leu 
        35                  40                  45              


Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg Tyr Asp Leu Thr Val 
    50                  55                  60                  


Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Val Lys Lys Met Lys Arg 
65                  70                  75                  80  


Tyr His Val Gly Lys Val Trp Arg Arg Glu Ser Pro Thr Ile Val Gln 
                85                  90                  95      


Gly Arg Tyr Arg Glu Phe Cys Gln Cys Asp Phe Asp Ile Ala Gly Gln 
            100                 105                 110         


Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu Lys Ile Met Cys Glu 
        115                 120                 125             


Ile Leu Ser Gly Leu Gln Leu Gly Asp Phe Leu Ile Lys Val Asn Asp 
    130                 135                 140                 


Arg Arg Ile Val Asp Gly Met Phe Ala Val Cys Gly Val Pro Glu Ser 
145                 150                 155                 160 


Lys Phe Arg Ala Ile Cys Ser Ser Ile Asp Lys Leu Asp Lys Met Ala 
                165                 170                 175     


Trp Lys Asp Val Arg His Glu Met Val Val Lys Lys Gly Leu Ala Pro 
            180                 185                 190         


Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln Cys His Gly Gly Val 
        195                 200                 205             


Ser Leu Val Glu Gln Met Phe Gln Asp Pro Arg Leu Ser Gln Asn Lys 
    210                 215                 220                 


Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr Leu 
225                 230                 235                 240 


Thr Leu Phe Gly Ile Ala Asp Lys Ile Ser Phe Asp Leu Ser Leu Ala 
                245                 250                 255     


Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu Leu 
            260                 265                 270         


Gln Thr Pro Thr Gln Ala Gly Glu Glu Pro Leu Asn Val Gly Ser Val 
        275                 280                 285             


Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly Met Phe Asp Pro Lys 
    290                 295                 300                 


Gly His Lys Val Pro Cys Val Gly Leu Ser Ile Gly Val Glu Arg Ile 
305                 310                 315                 320 


Phe Tyr Ile Val Glu Gln Arg Met Lys Thr Lys Gly Glu Lys Val Arg 
                325                 330                 335     


Thr Thr Glu Thr Gln Val Phe Val Ala Thr Pro Gln Lys Asn Phe Leu 
            340                 345                 350         


Gln Glu Arg Leu Lys Leu Ile Ala Glu Leu Trp Asp Ser Gly Ile Lys 
        355                 360                 365             


Ala Glu Met Leu Tyr Lys Asn Asn Pro Lys Leu Leu Thr Gln Leu His 
    370                 375                 380                 


Tyr Cys Glu Ser Thr Gly Ile Pro Leu Val Val Ile Ile Gly Glu Gln 
385                 390                 395                 400 


Glu Leu Lys Glu Gly Val Ile Lys Ile Arg Ser Val Ala Ser Arg Glu 
                405                 410                 415     


Glu Val Ala Ile Lys Arg Glu Asn Phe Val Ala Glu Ile Gln Lys Arg 
            420                 425                 430         


Leu Ser Glu Ser 
        435     


<210>  6399
<211>  293
<212>  PRT
<213>  Homo Sapiens

<400>  6399

Met Val Val Arg Glu Lys Ile Leu Asp Leu Val Ile Ser Cys Phe Lys 
1               5                   10                  15      


Arg His Gly Ala Lys Gly Met Asp Thr Pro Ala Phe Glu Leu Lys Glu 
            20                  25                  30          


Thr Leu Thr Glu Lys Tyr Gly Glu Asp Ser Gly Leu Met Tyr Asp Leu 
        35                  40                  45              


Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg Tyr Asp Leu Thr Val 
    50                  55                  60                  


Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Val Lys Lys Met Lys Arg 
65                  70                  75                  80  


Tyr His Val Gly Lys Val Trp Arg Arg Glu Ser Pro Thr Ile Val Gln 
                85                  90                  95      


Gly Arg Tyr Arg Glu Phe Cys Gln Cys Asp Phe Asp Ile Ala Gly Gln 
            100                 105                 110         


Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu Lys Ile Met Cys Glu 
        115                 120                 125             


Ile Leu Ser Gly Leu Gln Leu Gly Asp Phe Leu Ile Lys Val Asn Asp 
    130                 135                 140                 


Arg Arg Ile Val Asp Gly Met Phe Ala Val Cys Gly Val Pro Glu Ser 
145                 150                 155                 160 


Lys Phe Arg Ala Ile Cys Ser Ser Ile Asp Lys Leu Asp Lys Met Ala 
                165                 170                 175     


Trp Lys Asp Val Arg His Glu Met Val Val Lys Lys Gly Leu Ala Pro 
            180                 185                 190         


Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln Cys His Gly Gly Val 
        195                 200                 205             


Ser Leu Val Glu Gln Met Phe Gln Asp Pro Arg Leu Ser Gln Asn Lys 
    210                 215                 220                 


Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr Leu 
225                 230                 235                 240 


Thr Leu Phe Gly Ile Ala Asp Lys Ile Ser Phe Asp Leu Ser Leu Ala 
                245                 250                 255     


Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu Leu 
            260                 265                 270         


Gln Thr Pro Thr Gln Ala Gly Glu Glu Pro Leu Asn Val Gly Ser Val 
        275                 280                 285             


Ala Ala Gly Gly Arg 
    290             


<210>  6400
<211>  436
<212>  PRT
<213>  Homo Sapiens

<400>  6400

Met Val Val Arg Glu Lys Ile Leu Asp Leu Val Ile Ser Cys Phe Lys 
1               5                   10                  15      


Arg His Gly Ala Lys Gly Met Asp Thr Pro Ala Phe Glu Leu Lys Glu 
            20                  25                  30          


Thr Leu Thr Glu Lys Tyr Gly Glu Asp Ser Gly Leu Met Tyr Asp Leu 
        35                  40                  45              


Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg Tyr Asp Leu Thr Val 
    50                  55                  60                  


Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Val Lys Lys Met Lys Arg 
65                  70                  75                  80  


Tyr His Val Gly Lys Val Trp Arg Arg Glu Ser Pro Thr Ile Val Gln 
                85                  90                  95      


Gly Arg Tyr Arg Glu Phe Cys Gln Cys Asp Phe Asp Ile Ala Gly Gln 
            100                 105                 110         


Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu Lys Ile Met Cys Glu 
        115                 120                 125             


Ile Leu Ser Gly Leu Gln Leu Gly Asp Phe Leu Ile Lys Val Asn Asp 
    130                 135                 140                 


Arg Arg Ile Val Asp Gly Met Phe Ala Val Cys Gly Val Pro Glu Ser 
145                 150                 155                 160 


Lys Phe Arg Ala Ile Cys Ser Ser Ile Asp Lys Leu Asp Lys Met Ala 
                165                 170                 175     


Trp Lys Asp Val Arg His Glu Met Val Val Lys Lys Gly Leu Ala Pro 
            180                 185                 190         


Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln Cys His Gly Gly Val 
        195                 200                 205             


Ser Leu Val Glu Gln Met Phe Gln Asp Pro Arg Leu Ser Gln Asn Lys 
    210                 215                 220                 


Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr Leu 
225                 230                 235                 240 


Thr Leu Phe Gly Ile Ala Asp Lys Ile Ser Phe Asp Leu Ser Leu Ala 
                245                 250                 255     


Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu Leu 
            260                 265                 270         


Gln Thr Pro Thr Gln Ala Gly Glu Glu Pro Leu Asn Val Gly Ser Val 
        275                 280                 285             


Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly Met Phe Asp Pro Lys 
    290                 295                 300                 


Gly His Lys Val Pro Cys Val Gly Leu Ser Ile Gly Val Glu Arg Ile 
305                 310                 315                 320 


Phe Tyr Ile Val Glu Gln Arg Met Lys Thr Lys Gly Glu Lys Val Arg 
                325                 330                 335     


Thr Thr Glu Thr Gln Val Phe Val Ala Thr Pro Gln Lys Asn Phe Leu 
            340                 345                 350         


Gln Glu Arg Leu Lys Leu Ile Ala Glu Leu Trp Asp Ser Gly Ile Lys 
        355                 360                 365             


Ala Glu Met Leu Tyr Lys Asn Asn Pro Lys Leu Leu Thr Gln Leu His 
    370                 375                 380                 


Tyr Cys Glu Ser Thr Gly Ile Pro Leu Val Val Ile Ile Gly Glu Gln 
385                 390                 395                 400 


Glu Leu Lys Glu Gly Val Ile Lys Ile Arg Ser Val Ala Ser Arg Glu 
                405                 410                 415     


Glu Val Ala Ile Lys Arg Glu Asn Phe Val Ala Glu Ile Gln Lys Arg 
            420                 425                 430         


Leu Ser Glu Ser 
        435     


<210>  6401
<211>  219
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6401

Xaa Ala Ser Leu Leu Ser Gln Leu Leu Arg Pro Pro Cys Ala Ser Cys 
1               5                   10                  15      


Thr Gly Ala Val Arg Cys Gln Ser Gln Val Ala Glu Ala Val Leu Thr 
            20                  25                  30          


Ser Gln Leu Lys Ala His Gln Glu Lys Pro Asn Phe Ile Ile Lys Thr 
        35                  40                  45              


Pro Lys Gly Thr Arg Asp Leu Ser Pro Gln His Met Val Val Arg Glu 
    50                  55                  60                  


Lys Ile Leu Asp Leu Val Ile Ser Cys Phe Lys Arg His Gly Ala Lys 
65                  70                  75                  80  


Gly Met Asp Thr Pro Ala Phe Glu Leu Lys Glu Thr Leu Thr Glu Lys 
                85                  90                  95      


Tyr Gly Glu Asp Ser Gly Leu Met Tyr Asp Leu Lys Asp Gln Gly Gly 
            100                 105                 110         


Glu Leu Leu Ser Leu Arg Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr 
        115                 120                 125             


Leu Ala Met Asn Lys Val Lys Lys Met Lys Arg Tyr His Val Gly Lys 
    130                 135                 140                 


Val Trp Arg Arg Glu Ser Pro Thr Ile Val Gln Gly Arg Tyr Arg Glu 
145                 150                 155                 160 


Phe Cys Gln Cys Asp Phe Asp Ile Ala Gly Gln Phe Asp Pro Met Ile 
                165                 170                 175     


Pro Asp Ala Glu Cys Leu Lys Ile Met Cys Glu Ile Leu Ser Gly Leu 
            180                 185                 190         


Gln Leu Gly Asp Phe Leu Ile Lys Glu Ser Arg Tyr Cys His Cys Phe 
        195                 200                 205             


Glu Trp Lys Gly Ile Asp Lys His Leu Gly His 
    210                 215                 


<210>  6402
<211>  223
<212>  PRT
<213>  Homo Sapiens

<400>  6402

Met His Pro Gln Val Val Ile Leu Ser Leu Ile Leu His Leu Ala Asp 
1               5                   10                  15      


Ser Val Ala Gly Ser Val Lys Val Gly Gly Glu Ala Gly Pro Ser Val 
            20                  25                  30          


Thr Leu Pro Cys His Tyr Ser Gly Ala Val Thr Ser Met Cys Trp Asn 
        35                  40                  45              


Arg Gly Ser Cys Ser Leu Phe Thr Cys Gln Asn Gly Ile Val Trp Thr 
    50                  55                  60                  


Asn Gly Thr His Val Thr Tyr Arg Lys Asp Thr Arg Tyr Lys Leu Leu 
65                  70                  75                  80  


Gly Asp Leu Ser Arg Arg Asp Val Ser Leu Thr Ile Glu Asn Thr Ala 
                85                  90                  95      


Val Ser Asp Ser Gly Val Tyr Cys Cys Arg Val Glu His Arg Gly Trp 
            100                 105                 110         


Phe Asn Asp Met Lys Ile Thr Val Ser Leu Glu Ile Val Pro Pro Lys 
        115                 120                 125             


Val Thr Thr Thr Pro Ile Val Thr Thr Val Pro Thr Val Thr Thr Val 
    130                 135                 140                 


Arg Thr Ser Thr Thr Val Pro Thr Thr Thr Thr Val Pro Met Thr Thr 
145                 150                 155                 160 


Val Pro Thr Thr Thr Val Pro Thr Thr Met Ser Ile Pro Thr Thr Thr 
                165                 170                 175     


Thr Val Leu Thr Thr Met Thr Val Ser Thr Thr Thr Ser Val Pro Thr 
            180                 185                 190         


Thr Thr Ser Ile Pro Thr Thr Thr Ser Val Pro Val Thr Thr Thr Val 
        195                 200                 205             


Ser Thr Phe Val Pro Pro Met Pro Leu Pro Arg Gln Asn His Glu 
    210                 215                 220             


<210>  6403
<211>  364
<212>  PRT
<213>  Homo Sapiens

<400>  6403

Met His Pro Gln Val Val Ile Leu Ser Leu Ile Leu His Leu Ala Asp 
1               5                   10                  15      


Ser Val Ala Gly Ser Val Lys Val Gly Gly Glu Ala Gly Pro Ser Val 
            20                  25                  30          


Thr Leu Pro Cys His Tyr Ser Gly Ala Val Thr Ser Met Cys Trp Asn 
        35                  40                  45              


Arg Gly Ser Cys Ser Leu Phe Thr Cys Gln Asn Gly Ile Val Trp Thr 
    50                  55                  60                  


Asn Gly Thr His Val Thr Tyr Arg Lys Asp Thr Arg Tyr Lys Leu Leu 
65                  70                  75                  80  


Gly Asp Leu Ser Arg Arg Asp Val Ser Leu Thr Ile Glu Asn Thr Ala 
                85                  90                  95      


Val Ser Asp Ser Gly Val Tyr Cys Cys Arg Val Glu His Arg Gly Trp 
            100                 105                 110         


Phe Asn Asp Met Lys Ile Thr Val Ser Leu Glu Ile Val Pro Pro Lys 
        115                 120                 125             


Val Thr Thr Thr Pro Ile Val Thr Thr Val Pro Thr Val Thr Thr Val 
    130                 135                 140                 


Arg Thr Ser Thr Thr Val Pro Thr Thr Thr Thr Val Pro Met Thr Thr 
145                 150                 155                 160 


Val Pro Thr Thr Thr Val Pro Thr Thr Met Ser Ile Pro Thr Thr Thr 
                165                 170                 175     


Thr Val Leu Thr Thr Met Thr Val Ser Thr Thr Thr Ser Val Pro Thr 
            180                 185                 190         


Thr Thr Ser Ile Pro Thr Thr Thr Ser Val Pro Val Thr Thr Thr Val 
        195                 200                 205             


Ser Thr Phe Val Pro Pro Met Pro Leu Pro Arg Gln Asn His Glu Pro 
    210                 215                 220                 


Val Ala Thr Ser Pro Ser Ser Pro Gln Pro Ala Glu Thr His Pro Thr 
225                 230                 235                 240 


Thr Leu Gln Gly Ala Ile Arg Arg Glu Pro Thr Ser Ser Pro Leu Tyr 
                245                 250                 255     


Ser Tyr Thr Thr Asp Gly Asn Asp Thr Val Thr Glu Ser Ser Asp Gly 
            260                 265                 270         


Leu Trp Asn Asn Asn Gln Thr Gln Leu Phe Leu Glu His Ser Leu Leu 
        275                 280                 285             


Thr Ala Asn Thr Thr Lys Gly Ile Tyr Ala Gly Val Cys Ile Ser Val 
    290                 295                 300                 


Leu Val Leu Leu Ala Leu Leu Gly Val Ile Ile Ala Lys Lys Tyr Phe 
305                 310                 315                 320 


Phe Lys Lys Glu Val Gln Gln Leu Ser Val Ser Phe Ser Ser Leu Gln 
                325                 330                 335     


Ile Lys Ala Leu Gln Asn Ala Val Glu Lys Glu Val Gln Ala Glu Asp 
            340                 345                 350         


Asn Ile Tyr Ile Glu Asn Ser Leu Tyr Ala Thr Asp 
        355                 360                 


<210>  6404
<211>  401
<212>  PRT
<213>  Homo Sapiens

<400>  6404

Met His Pro Gln Val Val Ile Leu Ser Leu Ile Leu His Leu Ala Asp 
1               5                   10                  15      


Ser Val Ala Gly Ser Val Lys Val Gly Gly Glu Ala Gly Pro Ser Val 
            20                  25                  30          


Thr Leu Pro Cys His Tyr Ser Gly Ala Val Thr Ser Met Cys Trp Asn 
        35                  40                  45              


Arg Gly Ser Cys Ser Leu Phe Thr Cys Gln Asn Gly Ile Val Trp Thr 
    50                  55                  60                  


Asn Gly Thr His Val Thr Tyr Arg Lys Asp Thr Arg Tyr Lys Leu Leu 
65                  70                  75                  80  


Gly Asp Leu Ser Arg Arg Asp Val Ser Leu Thr Ile Glu Asn Thr Ala 
                85                  90                  95      


Val Ser Asp Ser Gly Val Tyr Cys Cys Arg Val Glu His Arg Gly Trp 
            100                 105                 110         


Phe Asn Asp Met Lys Ile Thr Val Ser Leu Glu Ile Val Pro Pro Lys 
        115                 120                 125             


Val Thr Thr Thr Pro Ile Val Thr Thr Val Pro Thr Val Thr Thr Val 
    130                 135                 140                 


Arg Thr Ser Thr Thr Val Pro Thr Thr Thr Thr Val Pro Met Thr Thr 
145                 150                 155                 160 


Val Pro Thr Thr Thr Val Pro Thr Thr Met Ser Ile Pro Thr Thr Thr 
                165                 170                 175     


Thr Val Leu Thr Thr Met Thr Val Ser Thr Thr Thr Ser Val Pro Thr 
            180                 185                 190         


Thr Thr Ser Ile Pro Thr Thr Thr Ser Val Pro Val Thr Thr Thr Val 
        195                 200                 205             


Ser Thr Phe Val Pro Pro Met Pro Leu Pro Arg Gln Asn His Glu Pro 
    210                 215                 220                 


Val Ala Thr Ser Pro Ser Ser Pro Gln Pro Ala Glu Thr His Pro Thr 
225                 230                 235                 240 


Thr Leu Gln Gly Ala Ile Arg Arg Glu Pro Thr Ser Ser Pro Leu Tyr 
                245                 250                 255     


Ser Tyr Thr Thr Asp Gly Asn Asp Thr Val Thr Glu Ser Ser Asp Gly 
            260                 265                 270         


Leu Trp Asn Asn Asn Gln Thr Gln Leu Phe Leu Glu His Ser Leu Leu 
        275                 280                 285             


Thr Ala Asn Thr Thr Lys Gly Ile Tyr Ala Gly Val Cys Ile Ser Val 
    290                 295                 300                 


Leu Val Leu Leu Ala Leu Leu Gly Val Ile Ile Ala Lys Met Phe His 
305                 310                 315                 320 


Leu Ala Ala Phe Lys Leu Lys Leu Cys Lys Met Gln Leu Lys Arg Lys 
                325                 330                 335     


Ser Lys Gln Lys Thr Ile Ser Thr Leu Arg Ile Val Phe Met Pro Arg 
            340                 345                 350         


Thr Lys Thr Gln Trp Cys Ser Leu Arg Val Tyr Ala His Glu Cys Arg 
        355                 360                 365             


Arg Leu Asn Arg His Gln His Ile Arg Arg Leu Leu Asp Pro Lys Thr 
    370                 375                 380                 


Ile Phe Leu Phe Gln Phe His Leu Ala Phe Gln His Val Ser Asp Thr 
385                 390                 395                 400 


Gly 
    


<210>  6405
<211>  364
<212>  PRT
<213>  Homo Sapiens

<400>  6405

Met His Pro Gln Val Val Ile Leu Ser Leu Ile Leu His Leu Ala Asp 
1               5                   10                  15      


Ser Val Ala Gly Ser Val Lys Val Gly Gly Glu Ala Gly Pro Ser Val 
            20                  25                  30          


Thr Leu Pro Cys His Tyr Ser Gly Ala Val Thr Ser Met Cys Trp Asn 
        35                  40                  45              


Arg Gly Ser Cys Ser Leu Phe Thr Cys Gln Asn Gly Ile Val Trp Thr 
    50                  55                  60                  


Asn Gly Thr His Val Thr Tyr Arg Lys Asp Thr Arg Tyr Lys Leu Leu 
65                  70                  75                  80  


Gly Asp Leu Ser Arg Arg Asp Val Ser Leu Thr Ile Glu Asn Thr Ala 
                85                  90                  95      


Val Ser Asp Ser Gly Val Tyr Cys Cys Arg Val Glu His Arg Gly Trp 
            100                 105                 110         


Phe Asn Asp Met Lys Ile Thr Val Ser Leu Glu Ile Val Pro Pro Lys 
        115                 120                 125             


Val Thr Thr Thr Pro Ile Val Thr Thr Val Pro Thr Val Thr Thr Val 
    130                 135                 140                 


Arg Thr Ser Thr Thr Val Pro Thr Thr Thr Thr Val Pro Met Thr Thr 
145                 150                 155                 160 


Val Pro Thr Thr Thr Val Pro Thr Thr Met Ser Ile Pro Thr Thr Thr 
                165                 170                 175     


Thr Val Leu Thr Thr Met Thr Val Ser Thr Thr Thr Ser Val Pro Thr 
            180                 185                 190         


Thr Thr Ser Ile Pro Thr Thr Thr Ser Val Pro Val Thr Thr Thr Val 
        195                 200                 205             


Ser Thr Phe Val Pro Pro Met Pro Leu Pro Arg Gln Asn His Glu Pro 
    210                 215                 220                 


Val Ala Thr Ser Pro Ser Ser Pro Gln Pro Ala Glu Thr His Pro Thr 
225                 230                 235                 240 


Thr Leu Gln Gly Ala Ile Arg Arg Glu Pro Thr Ser Ser Pro Leu Tyr 
                245                 250                 255     


Ser Tyr Thr Thr Asp Gly Asn Asp Thr Val Thr Glu Ser Ser Asp Gly 
            260                 265                 270         


Leu Trp Asn Asn Asn Gln Thr Gln Leu Phe Leu Glu His Ser Leu Leu 
        275                 280                 285             


Thr Ala Asn Thr Thr Lys Gly Ile Tyr Ala Gly Val Cys Ile Ser Val 
    290                 295                 300                 


Leu Val Leu Leu Ala Leu Leu Gly Val Ile Ile Ala Lys Lys Tyr Phe 
305                 310                 315                 320 


Phe Lys Lys Glu Val Gln Gln Leu Ser Val Ser Phe Ser Ser Leu Gln 
                325                 330                 335     


Ile Lys Ala Leu Gln Asn Ala Val Glu Lys Glu Val Gln Ala Glu Asp 
            340                 345                 350         


Asn Ile Tyr Ile Glu Asn Ser Leu Tyr Ala Thr Asp 
        355                 360                 


<210>  6406
<211>  401
<212>  PRT
<213>  Homo Sapiens

<400>  6406

Met His Pro Gln Val Val Ile Leu Ser Leu Ile Leu His Leu Ala Asp 
1               5                   10                  15      


Ser Val Ala Gly Ser Val Lys Val Gly Gly Glu Ala Gly Pro Ser Val 
            20                  25                  30          


Thr Leu Pro Cys His Tyr Ser Gly Ala Val Thr Ser Met Cys Trp Asn 
        35                  40                  45              


Arg Gly Ser Cys Ser Leu Phe Thr Cys Gln Asn Gly Ile Val Trp Thr 
    50                  55                  60                  


Asn Gly Thr His Val Thr Tyr Arg Lys Asp Thr Arg Tyr Lys Leu Leu 
65                  70                  75                  80  


Gly Asp Leu Ser Arg Arg Asp Val Ser Leu Thr Ile Glu Asn Thr Ala 
                85                  90                  95      


Val Ser Asp Ser Gly Val Tyr Cys Cys Arg Val Glu His Arg Gly Trp 
            100                 105                 110         


Phe Asn Asp Met Lys Ile Thr Val Ser Leu Glu Ile Val Pro Pro Lys 
        115                 120                 125             


Val Thr Thr Thr Pro Ile Val Thr Thr Val Pro Thr Val Thr Thr Val 
    130                 135                 140                 


Arg Thr Ser Thr Thr Val Pro Thr Thr Thr Thr Val Pro Met Thr Thr 
145                 150                 155                 160 


Val Pro Thr Thr Thr Val Pro Thr Thr Met Ser Ile Pro Thr Thr Thr 
                165                 170                 175     


Thr Val Leu Thr Thr Met Thr Val Ser Thr Thr Thr Ser Val Pro Thr 
            180                 185                 190         


Thr Thr Ser Ile Pro Thr Thr Thr Ser Val Pro Val Thr Thr Thr Val 
        195                 200                 205             


Ser Thr Phe Val Pro Pro Met Pro Leu Pro Arg Gln Asn His Glu Pro 
    210                 215                 220                 


Val Ala Thr Ser Pro Ser Ser Pro Gln Pro Ala Glu Thr His Pro Thr 
225                 230                 235                 240 


Thr Leu Gln Gly Ala Ile Arg Arg Glu Pro Thr Ser Ser Pro Leu Tyr 
                245                 250                 255     


Ser Tyr Thr Thr Asp Gly Asn Asp Thr Val Thr Glu Ser Ser Asp Gly 
            260                 265                 270         


Leu Trp Asn Asn Asn Gln Thr Gln Leu Phe Leu Glu His Ser Leu Leu 
        275                 280                 285             


Thr Ala Asn Thr Thr Lys Gly Ile Tyr Ala Gly Val Cys Ile Ser Val 
    290                 295                 300                 


Leu Val Leu Leu Ala Leu Leu Gly Val Ile Ile Ala Lys Met Phe His 
305                 310                 315                 320 


Leu Ala Ala Phe Lys Leu Lys Leu Cys Lys Met Gln Leu Lys Arg Lys 
                325                 330                 335     


Ser Lys Gln Lys Thr Ile Ser Thr Leu Arg Ile Val Phe Met Pro Arg 
            340                 345                 350         


Thr Lys Thr Gln Trp Cys Ser Leu Arg Val Tyr Ala His Glu Cys Arg 
        355                 360                 365             


Arg Leu Asn Arg His Gln His Ile Arg Arg Leu Leu Asp Pro Lys Thr 
    370                 375                 380                 


Ile Phe Leu Phe Gln Phe His Leu Ala Phe Gln His Val Ser Asp Thr 
385                 390                 395                 400 


Gly 
    


<210>  6407
<211>  268
<212>  PRT
<213>  Homo Sapiens

<400>  6407

Met Gly Leu Ser Pro Ser Ala Pro Ala Val Ala Val Gln Ala Ser Asn 
1               5                   10                  15      


Ala Ser Ala Ser Pro Pro Ser Gly Cys Pro Met His Glu Gly Lys Met 
            20                  25                  30          


Lys Gly Cys Pro Val Asn Thr Glu Pro Ser Gly Pro Thr Cys Glu Lys 
        35                  40                  45              


Lys Thr Tyr Ser Val Pro Ala His Gln Glu Arg Ala Tyr Glu Tyr Val 
    50                  55                  60                  


Glu Cys Pro Ile Arg Gly Thr Ala Ala Glu Asn Lys Glu Asn Leu Asp 
65                  70                  75                  80  


Pro Ser Asn Leu Met Pro Pro Pro Asn Gln Thr Pro Ala Pro Asp Gln 
                85                  90                  95      


Pro Phe Ala Leu Ser Thr Val Arg Glu Glu Ser Ser Ile Pro Arg Ala 
            100                 105                 110         


Asp Ser Glu Lys Lys Trp Val Tyr Pro Ser Glu Gln Met Phe Trp Asn 
        115                 120                 125             


Ala Met Leu Lys Lys Gly Trp Lys Trp Lys Asp Glu Asp Ile Ser Gln 
    130                 135                 140                 


Lys Asp Met Tyr Asn Ile Ile Arg Ile His Asn Gln Asn Asn Glu Gln 
145                 150                 155                 160 


Ala Trp Lys Glu Ile Leu Lys Trp Glu Ala Leu His Ala Ala Glu Cys 
                165                 170                 175     


Pro Cys Gly Pro Ser Leu Ile Arg Phe Gly Gly Lys Ala Lys Glu Tyr 
            180                 185                 190         


Ser Pro Arg Ala Arg Ile Arg Ser Trp Met Gly Tyr Glu Leu Pro Phe 
        195                 200                 205             


Asp Arg His Asp Trp Ile Ile Asn Arg Cys Gly Thr Glu Val Arg Tyr 
    210                 215                 220                 


Val Ile Asp Tyr Tyr Asp Gly Gly Glu Val Asn Lys Asp Tyr Gln Phe 
225                 230                 235                 240 


Thr Ile Leu Asp Val Arg Pro Ala Leu Asp Ser Leu Ser Ala Val Trp 
                245                 250                 255     


Asp Arg Met Lys Val Ala Trp Trp Arg Trp Thr Ser 
            260                 265             


<210>  6408
<211>  268
<212>  PRT
<213>  Homo Sapiens

<400>  6408

Met Gly Leu Ser Pro Ser Ala Pro Ala Val Ala Val Gln Ala Ser Asn 
1               5                   10                  15      


Ala Ser Ala Ser Pro Pro Ser Gly Cys Pro Met His Glu Gly Lys Met 
            20                  25                  30          


Lys Gly Cys Pro Val Asn Thr Glu Pro Ser Gly Pro Thr Cys Glu Lys 
        35                  40                  45              


Lys Thr Tyr Ser Val Pro Ala His Gln Glu Arg Ala Tyr Glu Tyr Val 
    50                  55                  60                  


Glu Cys Pro Ile Arg Gly Thr Ala Ala Glu Asn Lys Glu Asn Leu Asp 
65                  70                  75                  80  


Pro Ser Asn Leu Met Pro Pro Pro Asn Gln Thr Pro Ala Pro Asp Gln 
                85                  90                  95      


Pro Phe Ala Leu Ser Thr Val Arg Glu Glu Ser Ser Ile Pro Arg Ala 
            100                 105                 110         


Asp Ser Glu Lys Lys Trp Val Tyr Pro Ser Glu Gln Met Phe Trp Asn 
        115                 120                 125             


Ala Met Leu Lys Lys Gly Trp Lys Trp Lys Asp Glu Asp Ile Ser Gln 
    130                 135                 140                 


Lys Asp Met Tyr Asn Ile Ile Arg Ile His Asn Gln Asn Asn Glu Gln 
145                 150                 155                 160 


Ala Trp Lys Glu Ile Leu Lys Trp Glu Ala Leu His Ala Ala Glu Cys 
                165                 170                 175     


Pro Cys Gly Pro Ser Leu Ile Arg Phe Gly Gly Lys Ala Lys Glu Tyr 
            180                 185                 190         


Ser Pro Arg Ala Arg Ile Arg Ser Trp Met Gly Tyr Glu Leu Pro Phe 
        195                 200                 205             


Asp Arg His Asp Trp Ile Ile Asn Arg Cys Gly Thr Glu Val Arg Tyr 
    210                 215                 220                 


Val Ile Asp Tyr Tyr Asp Gly Gly Glu Val Asn Lys Asp Tyr Gln Phe 
225                 230                 235                 240 


Thr Ile Leu Asp Val Arg Pro Ala Leu Asp Ser Leu Ser Ala Val Trp 
                245                 250                 255     


Asp Arg Met Lys Val Ala Trp Trp Arg Trp Thr Ser 
            260                 265             


<210>  6409
<211>  268
<212>  PRT
<213>  Homo Sapiens

<400>  6409

Met Gly Leu Ser Pro Ser Ala Pro Ala Val Ala Val Gln Ala Ser Asn 
1               5                   10                  15      


Ala Ser Ala Ser Pro Pro Ser Gly Cys Pro Met His Glu Gly Lys Met 
            20                  25                  30          


Lys Gly Cys Pro Val Asn Thr Glu Pro Ser Gly Pro Thr Cys Glu Lys 
        35                  40                  45              


Lys Thr Tyr Ser Val Pro Ala His Gln Glu Arg Ala Tyr Glu Tyr Val 
    50                  55                  60                  


Glu Cys Pro Ile Arg Gly Thr Ala Ala Glu Asn Lys Glu Asn Leu Asp 
65                  70                  75                  80  


Pro Ser Asn Leu Met Pro Pro Pro Asn Gln Thr Pro Ala Pro Asp Gln 
                85                  90                  95      


Pro Phe Ala Leu Ser Thr Val Arg Glu Glu Ser Ser Ile Pro Arg Ala 
            100                 105                 110         


Asp Ser Glu Lys Lys Trp Val Tyr Pro Ser Glu Gln Met Phe Trp Asn 
        115                 120                 125             


Ala Met Leu Lys Lys Gly Trp Lys Trp Lys Asp Glu Asp Ile Ser Gln 
    130                 135                 140                 


Lys Asp Met Tyr Asn Ile Ile Arg Ile His Asn Gln Asn Asn Glu Gln 
145                 150                 155                 160 


Ala Trp Lys Glu Ile Leu Lys Trp Glu Ala Leu His Ala Ala Glu Cys 
                165                 170                 175     


Pro Cys Gly Pro Ser Leu Ile Arg Phe Gly Gly Lys Ala Lys Glu Tyr 
            180                 185                 190         


Ser Pro Arg Ala Arg Ile Arg Ser Trp Met Gly Tyr Glu Leu Pro Phe 
        195                 200                 205             


Asp Arg His Asp Trp Ile Ile Asn Arg Cys Gly Thr Glu Val Arg Tyr 
    210                 215                 220                 


Val Ile Asp Tyr Tyr Asp Gly Gly Glu Val Asn Lys Asp Tyr Gln Phe 
225                 230                 235                 240 


Thr Ile Leu Asp Val Arg Pro Ala Leu Asp Ser Leu Ser Ala Val Trp 
                245                 250                 255     


Asp Arg Met Lys Val Ala Trp Trp Arg Trp Thr Ser 
            260                 265             


<210>  6410
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  6410

Met Asn Leu Pro Ser Thr Lys Val Ser Trp Ala Ala Val Thr Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Pro Pro Ala Leu Leu Ser Ser Gly Ala Ala 
            20                  25                  30          


Ala Gln Pro Leu Pro Asp Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg 
        35                  40                  45              


Leu Tyr Glu Leu Leu His Gly Ala Gly Asn His Ala Ala Gly Ile Leu 
    50                  55                  60                  


Thr Leu Gly Lys Arg Arg Ser Gly Pro Pro Gly Leu Gln Gly Arg Leu 
65                  70                  75                  80  


Gln Arg Leu Leu Gln Ala Ser Gly Asn His Ala Ala Gly Ile Leu Thr 
                85                  90                  95      


Met Gly Arg Arg Ala Gly Ala Glu Pro Ala Pro Arg Pro Cys Leu Gly 
            100                 105                 110         


Arg Arg Cys Ser Ala Pro Ala Ala Ala Ser Val Ala Pro Gly Gly Gln 
        115                 120                 125             


Ser Gly Ile 
    130     


<210>  6411
<211>  223
<212>  PRT
<213>  Homo Sapiens

<400>  6411

Met Ala Ala Trp Gly Cys Val Ala Ala Leu Gly Ala Ala Arg Gly Leu 
1               5                   10                  15      


Cys Trp Arg Ala Ala Arg Ala Ala Ala Gly Leu Gln Gly Arg Pro Ala 
            20                  25                  30          


Arg Arg Cys Tyr Ala Val Gly Pro Ala Gln Pro Leu Pro Arg Asn Asp 
        35                  40                  45              


Phe Pro Arg Ile Glu Gly Val Leu Leu Leu Gly Glu Pro Val Arg Trp 
    50                  55                  60                  


Glu Thr Ser Leu Gln Leu Ile Met Asp Val Leu Leu Ser Asn Gly Ser 
65                  70                  75                  80  


Pro Gly Ala Gly Leu Ala Thr Pro Pro Tyr Pro His Leu Pro Val Leu 
                85                  90                  95      


Ala Ser Asn Met Asp Leu Leu Trp Met Ala Glu Ala Lys Met Pro Ser 
            100                 105                 110         


Asp Asn Pro Met Ser Asp Val Tyr Gly Ala Asn Leu Phe His Gln Tyr 
        115                 120                 125             


Leu Gln Lys Ala Thr His Asp Gly Ala Pro Glu Leu Gly Ala Gly Gly 
    130                 135                 140                 


Thr Arg Gln Gln Gln Pro Ser Ala Ser Gln Ser Cys Ile Ser Ile Leu 
145                 150                 155                 160 


Val Cys Thr Gly Val Tyr Asn Pro Arg Asn Pro Gln Ser Thr Glu Pro 
                165                 170                 175     


Val Leu Gly Gly Gly Glu Pro Pro Phe His Gly His Arg Asp Leu Cys 
            180                 185                 190         


Phe Ser Pro Gly Leu Met Glu Ala Ser His Val Val Asn Asp Val Asn 
        195                 200                 205             


Glu Ala Val Gln Leu Val Phe Arg Lys Glu Gly Trp Ala Leu Glu 
    210                 215                 220             


<210>  6412
<211>  423
<212>  PRT
<213>  Homo Sapiens

<400>  6412

Met Ala Ala Trp Gly Cys Val Ala Ala Leu Gly Ala Ala Arg Gly Leu 
1               5                   10                  15      


Cys Trp Arg Ala Ala Arg Ala Ala Ala Gly Leu Gln Gly Arg Pro Ala 
            20                  25                  30          


Arg Arg Cys Tyr Ala Val Gly Pro Ala Gln Ser Pro Pro Thr Phe Gly 
        35                  40                  45              


Phe Leu Leu Asp Ile Asp Gly Val Leu Val Arg Gly His Arg Val Ile 
    50                  55                  60                  


Pro Ala Ala Leu Lys Ala Phe Arg Arg Leu Val Asn Ser Gln Gly Gln 
65                  70                  75                  80  


Leu Arg Val Pro Val Val Phe Val Thr Asn Ala Gly Asn Ile Leu Gln 
                85                  90                  95      


His Ser Lys Ala Gln Glu Leu Ser Ala Leu Leu Gly Cys Glu Val Asp 
            100                 105                 110         


Ala Asp Gln Val Ile Leu Ser His Ser Pro Met Lys Leu Phe Ser Glu 
        115                 120                 125             


Tyr His Glu Lys Arg Met Leu Val Ser Gly Gln Gly Pro Val Met Glu 
    130                 135                 140                 


Asn Ala Gln Gly Leu Gly Phe Arg Asn Val Val Thr Val Asp Glu Leu 
145                 150                 155                 160 


Arg Met Ala Phe Pro Leu Leu Asp Met Val Asp Leu Glu Arg Arg Leu 
                165                 170                 175     


Lys Thr Thr Pro Leu Pro Arg Asn Asp Phe Pro Arg Ile Glu Gly Val 
            180                 185                 190         


Leu Leu Leu Gly Glu Pro Val Arg Trp Glu Thr Ser Leu Gln Leu Ile 
        195                 200                 205             


Met Asp Val Leu Leu Ser Asn Gly Ser Pro Gly Ala Gly Leu Ala Thr 
    210                 215                 220                 


Pro Pro Tyr Pro His Leu Pro Val Leu Ala Ser Asn Met Asp Leu Leu 
225                 230                 235                 240 


Trp Met Ala Glu Ala Lys Met Pro Arg Phe Gly His Gly Thr Phe Leu 
                245                 250                 255     


Leu Cys Leu Glu Thr Ile Tyr Gln Lys Val Thr Gly Lys Glu Leu Arg 
            260                 265                 270         


Tyr Glu Gly Leu Met Gly Lys Pro Ser Ile Leu Thr Tyr Gln Tyr Ala 
        275                 280                 285             


Glu Asp Leu Ile Arg Arg Gln Ala Glu Arg Arg Gly Trp Ala Ala Pro 
    290                 295                 300                 


Ile Arg Lys Leu Tyr Ala Val Gly Asp Asn Pro Met Ser Asp Val Tyr 
305                 310                 315                 320 


Gly Ala Asn Leu Phe His Gln Tyr Leu Gln Lys Ala Thr His Asp Gly 
                325                 330                 335     


Ala Pro Glu Leu Gly Ala Gly Gly Thr Arg Gln Gln Gln Pro Ser Ala 
            340                 345                 350         


Ser Gln Ser Cys Ile Ser Ile Leu Val Cys Thr Gly Val Tyr Asn Pro 
        355                 360                 365             


Arg Asn Pro Gln Ser Thr Glu Pro Val Leu Gly Gly Gly Glu Pro Pro 
    370                 375                 380                 


Phe His Gly His Arg Asp Leu Cys Phe Ser Pro Gly Leu Met Glu Ala 
385                 390                 395                 400 


Ser His Val Val Asn Asp Val Asn Glu Ala Val Gln Leu Val Phe Arg 
                405                 410                 415     


Lys Glu Gly Trp Ala Leu Glu 
            420             


<210>  6413
<211>  393
<212>  PRT
<213>  Homo Sapiens

<400>  6413

Met Tyr Ala Trp Phe Phe Leu Pro Ser Phe Ser Gln Ser Pro Pro Thr 
1               5                   10                  15      


Phe Gly Phe Leu Leu Asp Ile Asp Gly Val Leu Val Arg Gly His Arg 
            20                  25                  30          


Val Ile Pro Ala Ala Leu Lys Ala Phe Arg Arg Leu Val Asn Ser Gln 
        35                  40                  45              


Gly Gln Leu Arg Val Pro Val Val Phe Val Thr Asn Ala Gly Asn Ile 
    50                  55                  60                  


Leu Gln His Ser Lys Ala Gln Glu Leu Ser Ala Leu Leu Gly Cys Glu 
65                  70                  75                  80  


Val Asp Ala Asp Gln Val Ile Leu Ser His Ser Pro Met Lys Leu Phe 
                85                  90                  95      


Ser Glu Tyr His Glu Lys Arg Met Leu Val Ser Gly Gln Gly Pro Val 
            100                 105                 110         


Met Glu Asn Ala Gln Gly Leu Gly Phe Arg Asn Val Val Thr Val Asp 
        115                 120                 125             


Glu Leu Arg Met Ala Phe Pro Leu Leu Asp Met Val Asp Leu Glu Arg 
    130                 135                 140                 


Arg Leu Lys Thr Thr Pro Leu Pro Arg Asn Asp Phe Pro Arg Ile Glu 
145                 150                 155                 160 


Gly Val Leu Leu Leu Gly Glu Pro Val Arg Trp Glu Thr Ser Leu Gln 
                165                 170                 175     


Leu Ile Met Asp Val Leu Leu Ser Asn Gly Ser Pro Gly Ala Gly Leu 
            180                 185                 190         


Ala Thr Pro Pro Tyr Pro His Leu Pro Val Leu Ala Ser Asn Met Asp 
        195                 200                 205             


Leu Leu Trp Met Ala Glu Ala Lys Met Pro Arg Phe Gly His Gly Thr 
    210                 215                 220                 


Phe Leu Leu Cys Leu Glu Thr Ile Tyr Gln Lys Val Thr Gly Lys Glu 
225                 230                 235                 240 


Leu Arg Tyr Glu Gly Leu Met Gly Lys Pro Ser Ile Leu Thr Tyr Gln 
                245                 250                 255     


Tyr Ala Glu Asp Leu Ile Arg Arg Gln Ala Glu Arg Arg Gly Trp Ala 
            260                 265                 270         


Ala Pro Ile Arg Lys Leu Tyr Ala Val Gly Asp Asn Pro Met Ser Asp 
        275                 280                 285             


Val Tyr Gly Ala Asn Leu Phe His Gln Tyr Leu Gln Lys Ala Thr His 
    290                 295                 300                 


Asp Gly Ala Pro Glu Leu Gly Ala Gly Gly Thr Arg Gln Gln Gln Pro 
305                 310                 315                 320 


Ser Ala Ser Gln Ser Cys Ile Ser Ile Leu Val Cys Thr Gly Val Tyr 
                325                 330                 335     


Asn Pro Arg Asn Pro Gln Ser Thr Glu Pro Val Leu Gly Gly Gly Glu 
            340                 345                 350         


Pro Pro Phe His Gly His Arg Asp Leu Cys Phe Ser Pro Gly Leu Met 
        355                 360                 365             


Glu Ala Ser His Val Val Asn Asp Val Asn Glu Ala Val Gln Leu Val 
    370                 375                 380                 


Phe Arg Lys Glu Gly Trp Ala Leu Glu 
385                 390             


<210>  6414
<211>  87
<212>  PRT
<213>  Homo Sapiens

<400>  6414

Met Glu Leu Ala His Ser Leu Leu Leu Asn Glu Glu Ala Tyr Asn Gln 
1               5                   10                  15      


Leu Gly Glu Val Gln Lys Ala Glu Phe Ile Phe Glu Trp Leu Arg Tyr 
            20                  25                  30          


Leu Glu Lys Leu Leu Leu Ala Thr Ser Arg Asn Asp Val Arg Glu Lys 
        35                  40                  45              


Gln Lys Thr Leu Val Glu Gln Leu Leu Ser Leu Leu Asn Ser Ser Pro 
    50                  55                  60                  


Gly Pro Pro Thr Arg Lys Leu Leu Ala Lys Asn Leu Ala Ile Leu Tyr 
65                  70                  75                  80  


Ser Ile Gly Asp Thr Phe Ser 
                85          


<210>  6415
<211>  113
<212>  PRT
<213>  Homo Sapiens

<400>  6415

Met Glu Leu Ala His Ser Leu Leu Leu Asn Glu Glu Ala Tyr Asn Gln 
1               5                   10                  15      


Leu Gly Glu Val Gln Lys Ala Glu Phe Ile Phe Glu Trp Leu Arg Tyr 
            20                  25                  30          


Leu Glu Lys Leu Leu Leu Ala Thr Ser Arg Asn Asp Val Arg Glu Lys 
        35                  40                  45              


Gln Lys Thr Leu Val Glu Gln Leu Leu Ser Leu Leu Asn Ser Ser Pro 
    50                  55                  60                  


Gly Pro Pro Thr Arg Lys Leu Leu Ala Lys Asn Leu Ala Ile Leu Tyr 
65                  70                  75                  80  


Ser Ile Gly Asp Thr Phe Ser Val His Glu Ala Ile Asp Lys Cys Asn 
                85                  90                  95      


Asp Leu Ile Arg Ser Lys Asp Asp Ser Pro Ser Tyr Leu Pro Thr Lys 
            100                 105                 110         


Leu 
    


<210>  6416
<211>  2046
<212>  PRT
<213>  Homo Sapiens

<400>  6416

Met Glu Leu Ala His Ser Leu Leu Leu Asn Glu Glu Ala Tyr Asn Gln 
1               5                   10                  15      


Leu Gly Glu Val Gln Lys Ala Glu Phe Ile Phe Glu Trp Leu Arg Tyr 
            20                  25                  30          


Leu Glu Lys Leu Leu Leu Ala Thr Ser Arg Asn Asp Val Arg Glu Lys 
        35                  40                  45              


Gln Lys Thr Leu Val Glu Gln Leu Leu Ser Leu Leu Asn Ser Ser Pro 
    50                  55                  60                  


Gly Pro Pro Thr Arg Lys Leu Leu Ala Lys Asn Leu Ala Ile Leu Tyr 
65                  70                  75                  80  


Ser Ile Gly Asp Thr Phe Ser Val His Glu Ala Ile Asp Lys Cys Asn 
                85                  90                  95      


Asp Leu Ile Arg Ser Lys Asp Asp Ser Pro Ser Tyr Leu Pro Thr Lys 
            100                 105                 110         


Leu Ala Ala Val Val Cys Leu Gly Ser Leu Tyr Lys Lys Leu Gly Arg 
        115                 120                 125             


Ile Leu Gly Asn Thr Phe Thr Asp Thr Val Gly Asn Ile Leu Lys Ala 
    130                 135                 140                 


Met Lys Ser Ala Glu Ser Gln Gly Arg Tyr Glu Ile Met Leu Ser Leu 
145                 150                 155                 160 


Gln Asn Ile Leu Asn Gly Leu Gly Ala Ala Ala Ala Pro Cys His Arg 
                165                 170                 175     


Asp Val Tyr Lys Ala Ala Arg Ser Cys Leu Thr Asp Arg Ser Met Ala 
            180                 185                 190         


Val Arg Cys Ala Ala Ala Lys Cys Leu Leu Glu Leu Gln Asn Glu Ala 
        195                 200                 205             


Ile Phe Met Trp Ser Thr Asp Leu Asp Ser Val Ala Thr Leu Cys Phe 
    210                 215                 220                 


Lys Ser Phe Glu Gly Ser Asn Tyr Asp Val Arg Ile Ser Val Ser Lys 
225                 230                 235                 240 


Leu Leu Gly Ile Ile Leu Ala Lys Ala Val Ile Ser Lys His Pro Gly 
                245                 250                 255     


Thr Ala Ala Ser Arg Gln Ser Ile Arg Arg Val Ser Leu Glu Glu Val 
            260                 265                 270         


Leu Glu Leu Leu Gly Thr Gly Phe Leu Arg Gly Ser Ser Gly Phe Leu 
        275                 280                 285             


Arg Ala Ser Gly Asp Met Leu Lys Gly Thr Ser Ser Val Ser Arg Asp 
    290                 295                 300                 


Val Arg Val Gly Val Thr Gln Ala Tyr Val Val Phe Val Ser Thr Leu 
305                 310                 315                 320 


Gly Gly Ala Trp Leu Glu Lys Asn Phe Ala Ala Phe Phe Ser His Ile 
                325                 330                 335     


Leu Ser Leu Ala Ser Pro Ser His Pro Lys Ala Thr Gln Thr Gln Ile 
            340                 345                 350         


Asp Ala Val Cys Cys Arg Arg Cys Val Ser Phe Ile Leu Arg Thr Thr 
        355                 360                 365             


Ile Gly Gly Leu Leu Gly Glu Lys Ala Gln Leu Ala Ala Val Lys Asp 
    370                 375                 380                 


Ile Cys Gln Ala Ile Trp Lys Leu Lys Lys Val Met Asp Ala Val Met 
385                 390                 395                 400 


Ser Asp Gly Asn Leu Glu Thr Arg Leu Gly Ser Thr Asp Val Ala Ala 
                405                 410                 415     


Ser Gln His Met Leu Val Cys Ala Leu Gln Glu Leu Gly Asn Leu Ile 
            420                 425                 430         


His Asn Leu Gly Thr Thr Ala Ala Pro Leu Leu Gln Asp Ser Ser Thr 
        435                 440                 445             


Gly Leu Leu Asp Ser Ile Leu Ser Val Ile Leu His Pro Ser Ile Ser 
    450                 455                 460                 


Val Arg Leu Ala Ala Ala Trp Cys Leu His Cys Ile Ala Val Ala Leu 
465                 470                 475                 480 


Pro Ser Tyr Leu Thr Pro Leu Leu Asp Arg Cys Leu Glu Arg Leu Thr 
                485                 490                 495     


Gly His Lys Ser Ser Pro Glu Ala Val Thr Gly Phe Ser Phe Ala Val 
            500                 505                 510         


Ala Ala Leu Leu Gly Ala Val Lys His Cys Pro Leu Gly Ile Pro His 
        515                 520                 525             


Gly Lys Gly Lys Ile Ile Met Thr Leu Ala Glu Asp Leu Leu Cys Ser 
    530                 535                 540                 


Ala Ala Gln Asn Ser Arg Leu Ser Ala Gln Arg Thr Gln Ala Gly Trp 
545                 550                 555                 560 


Leu Leu Ile Ser Ala Leu Met Thr Leu Gly Pro Ala Val Val Ser His 
                565                 570                 575     


His Leu Ala Arg Val Leu Leu Leu Trp Lys Cys Val Phe Pro Ala Ser 
            580                 585                 590         


Pro Lys Asp Leu Glu Thr Glu Lys Ser Arg Gly Asp Ser Phe Thr Trp 
        595                 600                 605             


Gln Val Thr Leu Glu Gly Arg Ala Gly Ala Leu Cys Ala Ile Lys Ser 
    610                 615                 620                 


Phe Val Ser His Cys Gly Asp Leu Leu Thr Glu Glu Val Thr Gln Arg 
625                 630                 635                 640 


Leu Leu Pro Pro Leu Pro Cys Ala Val Asp Leu Leu Thr Gln Leu Ser 
                645                 650                 655     


Ser Ile Leu Lys Met Tyr Gly Ser Pro Leu Lys Thr Pro Ser Val Val 
            660                 665                 670         


Tyr Arg Gln Arg Leu Tyr Glu Leu Leu Ile Leu Leu Pro Pro Glu Thr 
        675                 680                 685             


Tyr Glu Gly Asn Leu Cys Ala Ile Leu Arg Glu Leu Ala Ala Asp Leu 
    690                 695                 700                 


Thr Ala Pro Asp Ile Gln Val Ala Ala Ser Thr Phe Leu Leu Pro Pro 
705                 710                 715                 720 


Leu Cys His Gln Asp Asp Leu Leu Ile Leu Ser Pro Phe Leu Gln Glu 
                725                 730                 735     


Thr Asp His Arg Phe Ile Glu Glu Gln Leu Leu Leu Gly Asn Gly Val 
            740                 745                 750         


Ala Cys Gly Ser Leu Glu Tyr Asp Pro Tyr Ser Ile Tyr Glu Lys Asp 
        755                 760                 765             


Val Glu Gly Asp Ser Val Pro Lys Pro Leu Pro Pro Ala Leu Ser Val 
    770                 775                 780                 


Ile Ser Ser Ala Ser Lys Leu Phe Gly Val Val Cys Ala His Val Gly 
785                 790                 795                 800 


Glu Thr Gln Arg Leu Leu Ile Leu Glu Gln Leu Leu Asp Ser Ile Lys 
                805                 810                 815     


His Thr Lys Gly Ala Arg Gln Gln Val Val Gln Leu His Val Val Ser 
            820                 825                 830         


Ser Val Ser Ser Phe Leu Lys Tyr Val Ala Gly Ser Lys Gly Cys Leu 
        835                 840                 845             


Gly Pro Glu Glu Met Lys Arg Phe Ala Leu Thr Leu Val Met Gly Ala 
    850                 855                 860                 


Leu Glu Ser Pro Asn Pro Leu Leu Arg Cys Ala Ala Ala Glu Ser Trp 
865                 870                 875                 880 


Ala Arg Leu Ala Gln Val Val Asp Asp Gly Ala Phe Thr Ala Gly Leu 
                885                 890                 895     


Ala Gln Val Ser Phe Asp Lys Leu Lys Ser Ala Arg Asp Val Val Thr 
            900                 905                 910         


Arg Thr Gly His Ser Leu Ala Leu Gly Ser Leu His Arg Tyr Leu Gly 
        915                 920                 925             


Gly Ile Ser Ser Ser Gln His Leu Asn Ser Cys Ile Gly Ile Leu Tyr 
    930                 935                 940                 


Thr Leu Ala Gln Asp Ser Thr Ser Pro Asp Val Gln Thr Trp Ala Leu 
945                 950                 955                 960 


His Ser Leu Ser Leu Ile Ile Asp Ser Ala Gly Pro Leu Tyr Tyr Val 
                965                 970                 975     


His Val Glu Pro Thr Leu Ser Leu Ile Ile Met Leu Leu Leu Asn Val 
            980                 985                 990         


Pro Pro Thr His Ala Glu Val His  Gln Ser Leu Gly Arg  Cys Leu Asn 
        995                 1000                 1005             


Ala Leu  Ile Thr Thr Leu Gly  Pro Glu Leu Gln Gly  Asn Ser Thr 
    1010                 1015                 1020             


Ser Ile  Ser Thr Leu Arg Thr  Ser Cys Leu Leu Gly  Cys Ala Val 
    1025                 1030                 1035             


Met Gln  Asp Asn Pro Asp Cys  Leu Val Gln Ala Gln  Ala Ile Ser 
    1040                 1045                 1050             


Cys Leu  Gln Gln Leu His Met  Phe Ala Pro Arg His  Val Asn Leu 
    1055                 1060                 1065             


Ser Ser  Leu Val Ser Cys Leu  Cys Val Asn Leu Cys  Ser Pro Tyr 
    1070                 1075                 1080             


Leu Leu  Leu Arg Arg Ala Val  Leu Ala Cys Leu Arg  Gln Leu Val 
    1085                 1090                 1095             


Gln Arg  Glu Ala Ala Glu Val  Ser Glu His Ala Val  Met Leu Ala 
    1100                 1105                 1110             


Lys Asp  Ser Arg Glu Glu Leu  Thr Pro Asp Ala Asn  Ile Arg Glu 
    1115                 1120                 1125             


Val Gly  Leu Glu Gly Ala Leu  Leu Ile Leu Leu Asp  Lys Glu Thr 
    1130                 1135                 1140             


Asp Glu  Arg Leu Cys His Asp  Ile Lys Glu Thr Leu  Asn Tyr Met 
    1145                 1150                 1155             


Leu Thr  Ser Met Ala Val Glu  Lys Leu Ser Leu Trp  Leu Lys Leu 
    1160                 1165                 1170             


Cys Lys  Asp Val Leu Ala Ala  Ser Ala Asp Phe Thr  Ala Val Thr 
    1175                 1180                 1185             


Cys Val  Asp Thr Met Gln Glu  Glu Glu Gly Asp Lys  Gly Asp Asp 
    1190                 1195                 1200             


Ala Ser  Val Leu Thr Thr Arg  Arg Asp Glu Lys Ser  His Pro Phe 
    1205                 1210                 1215             


Thr Asn  Pro Arg Trp Ala Thr  Arg Val Phe Ala Ala  Glu Cys Val 
    1220                 1225                 1230             


Cys Arg  Ile Ile Asn Gln Cys  Glu Asn Ala Asn Ser  Ala His Phe 
    1235                 1240                 1245             


Asp Ile  Ala Leu Ala Gln Glu  Met Lys Lys Arg Asp  Ser Arg Asn 
    1250                 1255                 1260             


Asp Phe  Leu Val Leu His Leu  Ala Asp Leu Ile Arg  Met Ala Phe 
    1265                 1270                 1275             


Met Ala  Ala Thr Asp His Ser  Asp Gln Leu Arg Leu  Ser Gly Leu 
    1280                 1285                 1290             


Glu Met  Leu Leu Val Val Ile  Arg Arg Phe Ala Thr  Val Pro Glu 
    1295                 1300                 1305             


Pro Glu  Phe Pro Gly His Val  Ile Leu Glu Gln Tyr  Gln Ala Asn 
    1310                 1315                 1320             


Val Gly  Ala Ala Leu Arg Pro  Ala Phe Thr Ser Glu  Thr Pro Pro 
    1325                 1330                 1335             


Asp Val  Thr Ala Lys Ala Cys  Gln Val Cys Ser Ala  Trp Ile Ala 
    1340                 1345                 1350             


Ser Gly  Val Val Ser Asp Leu  Asn Asp Leu Arg Arg  Val His Gln 
    1355                 1360                 1365             


Leu Leu  Val Ser Ser Leu Thr  Lys Ile Gln Ala Gly  Lys Glu Ala 
    1370                 1375                 1380             


Leu Ser  His Leu Tyr Asn Glu  Ser Ala Ser Thr Met  Glu Ile Leu 
    1385                 1390                 1395             


Ala Val  Leu Lys Ala Trp Ala  Glu Val Tyr Ile Ile  Ala Val Gln 
    1400                 1405                 1410             


Arg His  Lys Asn His Arg Gln  Pro Leu Lys Thr Thr  Thr Cys Leu 
    1415                 1420                 1425             


Glu Asp  Gly Ile Arg Asn Gly  Ser Cys Ser Ser Asp  Gly Leu Leu 
    1430                 1435                 1440             


Asp Leu  Val Tyr Ala Asp Leu  Gly Thr Leu Ser Arg  Leu Trp Leu 
    1445                 1450                 1455             


Ala Ala  Leu Gln Asp Phe Ala  Leu Leu Thr Leu Pro  Ser Glu Phe 
    1460                 1465                 1470             


Ala Ser  Gln Leu Pro Ala Glu  Gly Gly Ala Phe Tyr  Thr Ala Glu 
    1475                 1480                 1485             


Thr Ser  Glu Asn Ala Lys Leu  His Tyr Tyr Asn Ser  Trp Ala Leu 
    1490                 1495                 1500             


Ile Leu  His Ala Thr Ala Leu  Trp Leu Thr Ser Thr  Gly Phe Val 
    1505                 1510                 1515             


Val Ala  Asp Pro Asp Glu Gly  Ala Ser Asn Leu Ser  Arg Pro Val 
    1520                 1525                 1530             


Thr Pro  Thr Ser Met Cys Gln  Gly Ser Ser Ser Gly  Ala Thr Ile 
    1535                 1540                 1545             


Lys Ser  Pro Glu Asp Val Tyr  Thr Asp Arg Phe His  Leu Ile Leu 
    1550                 1555                 1560             


Gly Ile  Ser Val Glu Phe Leu  Cys Ser Leu Arg Ser  Asp Ala Thr 
    1565                 1570                 1575             


Met Glu  Ser Ile Thr Ala Cys  Leu His Ala Leu Gln  Ala Leu Leu 
    1580                 1585                 1590             


Asp Val  Pro Trp Pro Arg Ser  Lys Ile Gly Ser Asp  Gln Asp Leu 
    1595                 1600                 1605             


Gly Ile  Glu Leu Leu Asn Val  Leu His Arg Val Ile  Leu Thr Arg 
    1610                 1615                 1620             


Glu Ser  Pro Ser Ile Gln Leu  Ala Ser Leu Glu Val  Val Arg Gln 
    1625                 1630                 1635             


Ile Ile  Cys Ala Ala Gln Glu  His Val Lys Glu Lys  Arg Arg Ser 
    1640                 1645                 1650             


Ala Glu  Val Asp Asp Gly Ala  Ala Glu Lys Glu Thr  Leu Pro Glu 
    1655                 1660                 1665             


Phe Gly  Glu Gly Lys Asp Thr  Gly Gly Leu Val Pro  Gly Lys Ser 
    1670                 1675                 1680             


Leu Val  Phe Ala Thr Leu Glu  Leu Cys Val Cys Ile  Leu Val Arg 
    1685                 1690                 1695             


Gln Leu  Pro Glu Leu Asn Pro  Lys Leu Thr Gly Ser  Pro Gly Val 
    1700                 1705                 1710             


Lys Ala  Thr Lys Pro Gln Ile  Leu Leu Glu Asp Gly  Ser Arg Leu 
    1715                 1720                 1725             


Val Ser  Ala Ala Leu Val Ile  Leu Ser Glu Leu Pro  Ala Val Cys 
    1730                 1735                 1740             


Ser Pro  Glu Gly Ser Ile Ser  Ile Leu Pro Thr Ile  Leu Tyr Leu 
    1745                 1750                 1755             


Thr Ile  Gly Val Leu Arg Glu  Thr Ala Val Lys Leu  Pro Gly Gly 
    1760                 1765                 1770             


Gln Leu  Ser Ser Thr Val Ala  Ala Ser Leu Gln Ala  Leu Lys Gly 
    1775                 1780                 1785             


Ile Leu  Ser Ser Pro Met Ala  Arg Ala Glu Lys Ser  Arg Thr Ala 
    1790                 1795                 1800             


Trp Thr  Asp Leu Leu Arg Ser  Ala Leu Thr Thr Ile  Leu Asp Cys 
    1805                 1810                 1815             


Trp Asp  Pro Val Asp Glu Thr  His Gln Glu Leu Asp  Glu Val Ser 
    1820                 1825                 1830             


Leu Leu  Thr Ala Ile Thr Val  Phe Ile Leu Ser Thr  Ser Pro Glu 
    1835                 1840                 1845             


Val Thr  Thr Ile Pro Cys Leu  Gln Lys Arg Cys Ile  Asp Lys Phe 
    1850                 1855                 1860             


Lys Ala  Thr Leu Glu Ile Lys  Asp Pro Val Val Gln  Ile Lys Thr 
    1865                 1870                 1875             


Tyr Gln  Leu Leu His Ser Ile  Phe Gln Tyr Pro Asn  Pro Ala Val 
    1880                 1885                 1890             


Ser Tyr  Pro Tyr Ile Tyr Ser  Leu Ala Ser Cys Ile  Met Glu Lys 
    1895                 1900                 1905             


Leu Gln  Glu Ile Asp Lys Arg  Lys Pro Glu Asn Thr  Ala Glu Leu 
    1910                 1915                 1920             


Glu Ile  Phe Gln Glu Gly Ile  Lys Val Leu Glu Thr  Leu Val Thr 
    1925                 1930                 1935             


Val Ala  Glu Glu His His Arg  Ala Gln Leu Val Ala  Cys Leu Leu 
    1940                 1945                 1950             


Pro Ile  Leu Ile Ser Phe Leu  Leu Asp Glu Asn Ser  Leu Gly Ser 
    1955                 1960                 1965             


Ala Thr  Ser Ile Met Arg Asn  Leu His Asp Phe Ala  Leu Gln Asn 
    1970                 1975                 1980             


Leu Met  Gln Ile Gly Pro Gln  Tyr Ser Ser Val Phe  Lys Ser Leu 
    1985                 1990                 1995             


Val Ala  Ser Ser Pro Ala Leu  Lys Ala Arg Leu Glu  Ala Ala Ile 
    2000                 2005                 2010             


Lys Gly  Asn Gln Glu Ser Val  Lys Val Lys Ile Pro  Thr Ser Lys 
    2015                 2020                 2025             


Tyr Thr  Lys Ser Pro Gly Lys  Asn Ser Ser Ile Gln  Leu Lys Thr 
    2030                 2035                 2040             


Ser Phe  Leu 
    2045     


<210>  6417
<211>  1599
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6417

Xaa Gly Glu Lys Ala Gln Leu Ala Ala Val Lys Asp Ile Cys Gln Ala 
1               5                   10                  15      


Ile Trp Lys Leu Lys Lys Val Met Asp Ala Val Met Ser Asp Gly Asn 
            20                  25                  30          


Leu Glu Thr Arg Leu Gly Ser Thr Asp Val Ala Ala Ser Gln His Met 
        35                  40                  45              


Leu Val Cys Ala Leu Gln Glu Leu Gly Asn Leu Ile His Asn Leu Gly 
    50                  55                  60                  


Thr Thr Ala Ala Pro Leu Leu Gln Asp Ser Ser Thr Gly Leu Leu Asp 
65                  70                  75                  80  


Ser Ile Leu Ser Val Ile Leu His Pro Ser Ile Ser Val Arg Leu Ala 
                85                  90                  95      


Ala Ala Trp Cys Leu His Cys Ile Ala Val Ala Leu Pro Ser Tyr Leu 
            100                 105                 110         


Thr Pro Leu Leu Asp Arg Cys Leu Glu Arg Leu Thr Gly His Lys Ser 
        115                 120                 125             


Ser Pro Glu Ala Val Thr Gly Phe Ser Phe Ala Val Ala Ala Leu Leu 
    130                 135                 140                 


Gly Ala Val Lys His Cys Pro Leu Gly Ile Pro His Gly Lys Gly Lys 
145                 150                 155                 160 


Ile Ile Met Thr Leu Ala Glu Asp Leu Leu Cys Ser Ala Ala Gln Asn 
                165                 170                 175     


Ser Arg Leu Ser Ala Gln Arg Thr Gln Ala Gly Trp Leu Leu Ile Ser 
            180                 185                 190         


Ala Leu Met Thr Leu Gly Pro Ala Val Val Ser His His Leu Ala Arg 
        195                 200                 205             


Val Leu Leu Leu Trp Lys Cys Val Phe Pro Ala Ser Pro Lys Asp Leu 
    210                 215                 220                 


Glu Thr Glu Lys Ser Arg Gly Asp Ser Phe Thr Trp Gln Val Thr Leu 
225                 230                 235                 240 


Glu Gly Arg Ala Gly Ala Leu Cys Ala Ile Lys Ser Phe Val Ser His 
                245                 250                 255     


Cys Gly Asp Leu Leu Thr Glu Glu Val Thr Gln Arg Leu Leu Pro Pro 
            260                 265                 270         


Leu Pro Cys Ala Val Asp Leu Leu Thr Gln Leu Ser Ser Ile Leu Lys 
        275                 280                 285             


Met Tyr Gly Ser Pro Leu Lys Thr Pro Ser Val Val Tyr Arg Gln Arg 
    290                 295                 300                 


Leu Tyr Glu Leu Leu Ile Leu Leu Pro Pro Glu Thr Tyr Glu Gly Asn 
305                 310                 315                 320 


Leu Cys Ala Ile Leu Arg Glu Leu Ala Ala Asp Leu Thr Ala Pro Asp 
                325                 330                 335     


Ile Gln Val Ala Ala Ser Thr Phe Leu Leu Pro Pro Leu Cys His Gln 
            340                 345                 350         


Asp Asp Leu Leu Ile Leu Ser Pro Phe Leu Gln Glu Thr Asp His Arg 
        355                 360                 365             


Phe Ile Glu Glu Gln Leu Leu Leu Gly Asn Gly Val Ala Cys Gly Ser 
    370                 375                 380                 


Leu Glu Tyr Asp Pro Tyr Ser Ile Tyr Glu Lys Asp Val Glu Gly Asp 
385                 390                 395                 400 


Ser Val Pro Lys Pro Leu Pro Pro Ala Leu Ser Val Ile Ser Ser Ala 
                405                 410                 415     


Ser Lys Leu Phe Gly Val Val Cys Ala His Val Gly Glu Thr Gln Arg 
            420                 425                 430         


Leu Leu Ile Leu Glu Gln Leu Leu Asp Ser Ile Lys His Thr Lys Gly 
        435                 440                 445             


Ala Arg Gln Gln Val Val Gln Leu His Val Val Ser Ser Val Ser Ser 
    450                 455                 460                 


Phe Leu Lys Tyr Val Ala Gly Ser Lys Gly Cys Leu Gly Pro Glu Glu 
465                 470                 475                 480 


Met Lys Arg Phe Ala Leu Thr Leu Val Met Gly Ala Leu Glu Ser Pro 
                485                 490                 495     


Asn Pro Leu Leu Arg Cys Ala Ala Ala Glu Ser Trp Ala Arg Leu Ala 
            500                 505                 510         


Gln Val Val Asp Asp Gly Ala Phe Thr Ala Gly Leu Ala Gln Val Ser 
        515                 520                 525             


Phe Asp Lys Leu Lys Ser Ala Arg Asp Val Val Thr Arg Thr Gly His 
    530                 535                 540                 


Ser Leu Ala Leu Gly Ser Leu His Arg Tyr Leu Gly Gly Ile Ser Ser 
545                 550                 555                 560 


Ser Gln His Leu Asn Ser Cys Ile Gly Ile Leu Tyr Thr Leu Ala Gln 
                565                 570                 575     


Asp Ser Thr Ser Pro Asp Val Gln Thr Trp Ala Leu His Ser Leu Ser 
            580                 585                 590         


Leu Ile Ile Asp Ser Ala Gly Pro Leu Tyr Tyr Val His Val Glu Pro 
        595                 600                 605             


Thr Leu Ser Leu Ile Ile Met Leu Leu Leu Asn Val Pro Pro Thr His 
    610                 615                 620                 


Ala Glu Val His Gln Ser Leu Gly Arg Cys Leu Asn Ala Leu Ile Thr 
625                 630                 635                 640 


Thr Leu Gly Pro Glu Leu Gln Gly Asn Ser Thr Ser Ile Ser Thr Leu 
                645                 650                 655     


Arg Thr Ser Cys Leu Leu Gly Cys Ala Val Met Gln Asp Asn Pro Asp 
            660                 665                 670         


Cys Leu Val Gln Ala Gln Ala Ile Ser Cys Leu Gln Gln Leu His Met 
        675                 680                 685             


Phe Ala Pro Arg His Val Asn Leu Ser Ser Leu Val Ser Cys Leu Cys 
    690                 695                 700                 


Val Asn Leu Cys Ser Pro Tyr Leu Leu Leu Arg Arg Ala Val Leu Ala 
705                 710                 715                 720 


Cys Leu Arg Gln Leu Val Gln Arg Glu Ala Ala Glu Val Ser Glu His 
                725                 730                 735     


Ala Val Met Leu Ala Lys Asp Ser Arg Glu Glu Leu Thr Pro Asp Ala 
            740                 745                 750         


Asn Ile Arg Glu Val Gly Leu Glu Gly Ala Leu Leu Ile Leu Leu Asp 
        755                 760                 765             


Lys Glu Thr Asp Glu Arg Leu Cys His Asp Ile Lys Glu Thr Leu Asn 
    770                 775                 780                 


Tyr Met Leu Thr Ser Met Ala Val Glu Lys Leu Ser Leu Trp Leu Lys 
785                 790                 795                 800 


Leu Cys Lys Asp Val Leu Ala Ala Ser Ala Asp Phe Thr Ala Val Thr 
                805                 810                 815     


Cys Val Asp Thr Met Gln Glu Glu Glu Gly Asp Lys Gly Asp Asp Ala 
            820                 825                 830         


Ser Val Leu Thr Thr Arg Arg Asp Glu Lys Ser His Pro Phe Thr Asn 
        835                 840                 845             


Pro Arg Trp Ala Thr Arg Val Phe Ala Ala Glu Cys Val Cys Arg Ile 
    850                 855                 860                 


Ile Asn Gln Cys Glu Asn Ala Asn Ser Ala His Phe Asp Ile Ala Leu 
865                 870                 875                 880 


Ala Gln Glu Met Lys Lys Arg Asp Ser Arg Asn Asp Phe Leu Val Leu 
                885                 890                 895     


His Leu Ala Asp Leu Ile Arg Met Ala Phe Met Ala Ala Thr Asp His 
            900                 905                 910         


Ser Asp Gln Leu Arg Leu Ser Gly Leu Glu Met Leu Leu Val Val Ile 
        915                 920                 925             


Arg Arg Phe Ala Thr Val Pro Glu Pro Glu Phe Pro Gly His Val Ile 
    930                 935                 940                 


Leu Glu Gln Tyr Gln Ala Asn Val Gly Ala Ala Leu Arg Pro Ala Phe 
945                 950                 955                 960 


Thr Ser Glu Thr Pro Pro Asp Val Thr Ala Lys Ala Cys Gln Val Cys 
                965                 970                 975     


Ser Ala Trp Ile Ala Ser Gly Val Val Ser Asp Leu Asn Asp Leu Arg 
            980                 985                 990         


Arg Val His Gln Leu Leu Val Ser  Ser Leu Thr Lys Ile  Gln Ala Gly 
        995                 1000                 1005             


Lys Glu  Ala Leu Ser His Leu  Tyr Asn Glu Ser Ala  Ser Thr Met 
    1010                 1015                 1020             


Glu Ile  Leu Ala Val Leu Lys  Ala Trp Ala Glu Val  Tyr Ile Ile 
    1025                 1030                 1035             


Ala Val  Gln Arg His Lys Asn  His Arg Gln Pro Leu  Lys Thr Thr 
    1040                 1045                 1050             


Thr Cys  Leu Glu Asp Gly Ile  Arg Asn Gly Ser Cys  Ser Ser Asp 
    1055                 1060                 1065             


Gly Leu  Leu Asp Leu Val Tyr  Ala Asp Leu Gly Thr  Leu Ser Arg 
    1070                 1075                 1080             


Leu Trp  Leu Ala Ala Leu Gln  Asp Phe Ala Leu Leu  Thr Leu Pro 
    1085                 1090                 1095             


Ser Glu  Phe Ala Ser Gln Leu  Pro Ala Glu Gly Gly  Ala Phe Tyr 
    1100                 1105                 1110             


Thr Ala  Glu Thr Ser Glu Asn  Ala Lys Leu His Tyr  Tyr Asn Ser 
    1115                 1120                 1125             


Trp Ala  Leu Ile Leu His Ala  Thr Ala Leu Trp Leu  Thr Ser Thr 
    1130                 1135                 1140             


Gly Phe  Val Val Ala Asp Pro  Asp Glu Gly Ala Ser  Asn Leu Ser 
    1145                 1150                 1155             


Arg Pro  Val Thr Pro Thr Ser  Met Cys Gln Gly Ser  Ser Ser Gly 
    1160                 1165                 1170             


Ala Thr  Ile Lys Ser Pro Glu  Asp Val Tyr Thr Asp  Arg Phe His 
    1175                 1180                 1185             


Leu Ile  Leu Gly Ile Ser Val  Glu Phe Leu Cys Ser  Leu Arg Ser 
    1190                 1195                 1200             


Asp Ala  Thr Met Glu Ser Ile  Thr Ala Cys Leu His  Ala Leu Gln 
    1205                 1210                 1215             


Ala Leu  Leu Asp Val Pro Trp  Pro Arg Ser Lys Ile  Gly Ser Asp 
    1220                 1225                 1230             


Gln Asp  Leu Gly Ile Glu Leu  Leu Asn Val Leu His  Arg Val Ile 
    1235                 1240                 1245             


Leu Thr  Arg Glu Ser Pro Ser  Ile Gln Leu Ala Ser  Leu Glu Val 
    1250                 1255                 1260             


Val Arg  Gln Ile Ile Cys Ala  Ala Gln Glu His Val  Lys Glu Lys 
    1265                 1270                 1275             


Arg Arg  Ser Ala Glu Val Asp  Asp Gly Ala Ala Glu  Lys Glu Thr 
    1280                 1285                 1290             


Leu Pro  Glu Phe Gly Glu Gly  Lys Asp Thr Gly Gly  Leu Val Pro 
    1295                 1300                 1305             


Gly Lys  Ser Leu Val Phe Ala  Thr Leu Glu Leu Cys  Val Cys Ile 
    1310                 1315                 1320             


Leu Val  Arg Gln Leu Pro Glu  Leu Asn Pro Lys Leu  Thr Gly Ser 
    1325                 1330                 1335             


Pro Gly  Val Lys Ala Thr Lys  Pro Gln Ile Leu Leu  Glu Asp Gly 
    1340                 1345                 1350             


Ser Arg  Leu Val Ser Ala Ala  Leu Val Ile Leu Ser  Glu Leu Pro 
    1355                 1360                 1365             


Ala Val  Cys Ser Pro Glu Val  Asp Glu Thr His Gln  Glu Leu Asp 
    1370                 1375                 1380             


Glu Val  Ser Leu Leu Thr Ala  Ile Thr Val Phe Ile  Leu Ser Thr 
    1385                 1390                 1395             


Ser Pro  Glu Val Thr Thr Ile  Pro Cys Leu Gln Lys  Arg Cys Ile 
    1400                 1405                 1410             


Asp Lys  Phe Lys Ala Thr Leu  Glu Ile Lys Asp Pro  Val Val Gln 
    1415                 1420                 1425             


Ile Lys  Thr Tyr Gln Leu Leu  His Ser Ile Phe Gln  Tyr Pro Asn 
    1430                 1435                 1440             


Pro Ala  Val Ser Tyr Pro Tyr  Ile Tyr Ser Leu Ala  Ser Cys Ile 
    1445                 1450                 1455             


Met Glu  Lys Leu Gln Glu Ile  Asp Lys Arg Lys Pro  Glu Asn Thr 
    1460                 1465                 1470             


Ala Glu  Leu Glu Ile Phe Gln  Glu Gly Ile Lys Val  Leu Glu Thr 
    1475                 1480                 1485             


Leu Val  Thr Val Ala Glu Glu  His His Arg Ala Gln  Leu Val Ala 
    1490                 1495                 1500             


Cys Leu  Leu Pro Ile Leu Ile  Ser Phe Leu Leu Asp  Glu Asn Ser 
    1505                 1510                 1515             


Leu Gly  Ser Ala Thr Ser Ile  Met Arg Asn Leu His  Asp Phe Ala 
    1520                 1525                 1530             


Leu Gln  Asn Leu Met Gln Ile  Gly Pro Gln Tyr Ser  Ser Val Phe 
    1535                 1540                 1545             


Lys Ser  Leu Val Ala Ser Ser  Pro Ala Leu Lys Ala  Arg Leu Glu 
    1550                 1555                 1560             


Ala Ala  Ile Lys Gly Asn Gln  Glu Ser Val Lys Val  Lys Ile Pro 
    1565                 1570                 1575             


Thr Ser  Lys Tyr Thr Lys Ser  Pro Gly Lys Asn Ser  Ser Ile Gln 
    1580                 1585                 1590             


Leu Lys  Thr Ser Phe Leu 
    1595                 


<210>  6418
<211>  124
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6418

Xaa Leu Leu Leu Arg Arg Ala Val Leu Ala Cys Leu Arg Gln Leu Val 
1               5                   10                  15      


Gln Arg Glu Ala Ala Glu Val Ser Glu His Ala Val Met Leu Ala Lys 
            20                  25                  30          


Asp Ser Arg Glu Glu Leu Thr Pro Asp Ala Asn Ile Arg Glu Val Gly 
        35                  40                  45              


Leu Glu Gly Ala Leu Leu Ile Leu Leu Asp Lys Glu Thr Asp Glu Arg 
    50                  55                  60                  


Leu Cys His Asp Ile Lys Glu Thr Leu Asn Tyr Met Leu Thr Ser Met 
65                  70                  75                  80  


Ala Val Glu Lys Leu Ser Leu Trp Leu Lys Leu Cys Lys Asp Val Leu 
                85                  90                  95      


Ala Ala Ser Ala Gly Lys Tyr Trp Thr Leu Ser Val Lys Ile Ile Lys 
            100                 105                 110         


Leu Lys Phe Glu Thr Leu His Lys Ile Val Tyr His 
        115                 120                 


<210>  6419
<211>  896
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6419

Xaa Ser His Pro Lys Ala Thr Gln Thr Gln Ile Asp Ala Val Cys Cys 
1               5                   10                  15      


Arg Arg Cys Val Ser Phe Ile Leu Arg Thr Thr Ile Gly Gly Leu Leu 
            20                  25                  30          


Gly Glu Lys Ala Gln Leu Ala Ala Val Lys Asp Ile Cys Gln Ala Ile 
        35                  40                  45              


Trp Lys Leu Lys Lys Val Met Asp Val Ala Ala Ser Gln His Met Leu 
    50                  55                  60                  


Val Cys Ala Leu Gln Glu Leu Gly Asn Leu Ile His Asn Leu Gly Thr 
65                  70                  75                  80  


Thr Ala Ala Pro Leu Leu Gln Asp Ser Ser Thr Gly Leu Leu Asp Ser 
                85                  90                  95      


Ile Leu Ser Val Ile Leu His Pro Ser Ile Ser Val Arg Leu Ala Ala 
            100                 105                 110         


Ala Trp Cys Leu His Cys Ile Ala Val Ala Leu Pro Ser Tyr Leu Thr 
        115                 120                 125             


Pro Leu Leu Asp Arg Cys Leu Glu Arg Leu Thr Gly His Lys Ser Ser 
    130                 135                 140                 


Pro Glu Ala Val Thr Gly Phe Ser Phe Ala Val Ala Ala Leu Leu Gly 
145                 150                 155                 160 


Ala Val Lys His Cys Pro Leu Gly Ile Pro His Gly Lys Gly Lys Ile 
                165                 170                 175     


Ile Met Thr Leu Ala Glu Asp Leu Leu Cys Ser Ala Ala Gln Asn Ser 
            180                 185                 190         


Arg Leu Ser Ala Gln Arg Thr Gln Ala Gly Trp Leu Leu Ile Ser Ala 
        195                 200                 205             


Leu Met Thr Leu Gly Pro Ala Val Val Ser His His Leu Ala Arg Val 
    210                 215                 220                 


Leu Leu Leu Trp Lys Cys Val Phe Pro Ala Ser Pro Lys Asp Leu Glu 
225                 230                 235                 240 


Thr Glu Lys Ser Arg Gly Asp Ser Phe Thr Trp Gln Val Thr Leu Glu 
                245                 250                 255     


Gly Arg Ala Gly Ala Leu Cys Ala Ile Lys Ser Phe Val Ser His Cys 
            260                 265                 270         


Gly Asp Leu Leu Thr Glu Glu Val Thr Gln Arg Leu Leu Pro Pro Leu 
        275                 280                 285             


Pro Cys Ala Val Asp Leu Leu Thr Gln Leu Ser Ser Ile Leu Lys Met 
    290                 295                 300                 


Tyr Gly Ser Pro Leu Lys Thr Pro Ser Val Val Tyr Arg Gln Arg Leu 
305                 310                 315                 320 


Tyr Glu Leu Leu Ile Leu Leu Pro Pro Glu Thr Tyr Glu Gly Asn Leu 
                325                 330                 335     


Cys Ala Ile Leu Arg Glu Leu Ala Ala Asp Leu Thr Ala Pro Asp Ile 
            340                 345                 350         


Gln Val Ala Ala Ser Thr Phe Leu Leu Pro Pro Leu Cys His Gln Asp 
        355                 360                 365             


Asp Leu Leu Ile Leu Ser Pro Phe Leu Gln Glu Thr Asp His Arg Phe 
    370                 375                 380                 


Ile Glu Glu Gln Leu Leu Leu Gly Asn Gly Val Ala Cys Gly Ser Leu 
385                 390                 395                 400 


Glu Tyr Asp Pro Tyr Ser Ile Tyr Glu Lys Asp Val Glu Gly Asp Ser 
                405                 410                 415     


Val Pro Lys Pro Leu Pro Pro Ala Leu Ser Val Ile Ser Ser Ala Ser 
            420                 425                 430         


Lys Leu Phe Gly Val Val Cys Ala His Val Gly Glu Thr Gln Arg Leu 
        435                 440                 445             


Leu Ile Leu Glu Gln Leu Leu Asp Ser Ile Lys His Thr Lys Gly Ala 
    450                 455                 460                 


Arg Gln Gln Val Val Gln Leu His Val Val Ser Ser Val Ser Ser Phe 
465                 470                 475                 480 


Leu Lys Tyr Val Ala Gly Ser Lys Gly Cys Leu Gly Pro Glu Glu Met 
                485                 490                 495     


Lys Arg Phe Ala Leu Thr Leu Val Met Gly Ala Leu Glu Ser Pro Asn 
            500                 505                 510         


Pro Leu Leu Arg Cys Ala Ala Ala Glu Ser Trp Ala Arg Leu Ala Gln 
        515                 520                 525             


Val Val Asp Asp Gly Ala Phe Thr Ala Gly Leu Ala Gln Val Ser Phe 
    530                 535                 540                 


Asp Lys Leu Lys Ser Ala Arg Asp Val Val Thr Arg Thr Gly His Ser 
545                 550                 555                 560 


Leu Ala Leu Gly Ser Leu His Arg Tyr Leu Gly Gly Ile Ser Ser Ser 
                565                 570                 575     


Gln His Leu Asn Ser Cys Ile Gly Ile Leu Tyr Thr Leu Ala Gln Asp 
            580                 585                 590         


Ser Thr Ser Pro Asp Val Gln Thr Trp Ala Leu His Ser Leu Ser Leu 
        595                 600                 605             


Ile Ile Asp Ser Ala Gly Pro Leu Tyr Tyr Val His Val Glu Pro Thr 
    610                 615                 620                 


Leu Ser Leu Ile Ile Met Leu Leu Leu Asn Val Pro Pro Thr His Ala 
625                 630                 635                 640 


Glu Val His Gln Ser Leu Gly Arg Cys Leu Asn Ala Leu Ile Thr Thr 
                645                 650                 655     


Leu Gly Pro Glu Leu Gln Gly Asn Ser Thr Ser Ile Ser Thr Leu Arg 
            660                 665                 670         


Thr Ser Cys Leu Leu Gly Cys Ala Val Met Gln Asp Asn Pro Asp Cys 
        675                 680                 685             


Leu Val Gln Ala Gln Ala Ile Ser Cys Leu Gln Gln Leu His Met Phe 
    690                 695                 700                 


Ala Pro Arg His Val Asn Leu Ser Ser Leu Val Ser Cys Leu Cys Val 
705                 710                 715                 720 


Asn Leu Cys Ser Pro Tyr Leu Leu Leu Arg Arg Ala Val Leu Ala Cys 
                725                 730                 735     


Leu Arg Gln Leu Val Gln Arg Glu Ala Ala Glu Val Ser Glu His Ala 
            740                 745                 750         


Val Met Leu Ala Lys Asp Ser Arg Glu Glu Leu Thr Pro Asp Ala Asn 
        755                 760                 765             


Ile Arg Glu Val Gly Leu Glu Gly Ala Leu Leu Ile Leu Leu Asp Lys 
    770                 775                 780                 


Glu Thr Asp Glu Arg Leu Cys His Asp Ile Lys Glu Thr Leu Asn Tyr 
785                 790                 795                 800 


Met Leu Thr Ser Met Ala Val Glu Lys Leu Ser Leu Trp Leu Lys Leu 
                805                 810                 815     


Cys Lys Asp Val Leu Ala Ala Ser Ala Asp Phe Thr Ala Val Thr Cys 
            820                 825                 830         


Val Asp Thr Met Gln Glu Glu Glu Gly Asp Lys Gly Asp Asp Ala Ser 
        835                 840                 845             


Val Leu Thr Thr Arg Arg Asp Glu Lys Ser His Pro Phe Thr Asn Pro 
    850                 855                 860                 


Arg Trp Ala Thr Arg Val Phe Ala Ala Glu Cys Val Cys Arg Ile Ile 
865                 870                 875                 880 


Asn Gln Cys Glu Asn Ala Asn Ser Ala His Phe Asp Ile Ala Leu Ala 
                885                 890                 895     


<210>  6420
<211>  199
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6420

Xaa Ser Leu Ile Ile Met Leu Leu Leu Asn Val Pro Pro Thr His Ala 
1               5                   10                  15      


Glu Val His Gln Ser Leu Gly Arg Cys Leu Asn Ala Leu Ile Thr Thr 
            20                  25                  30          


Leu Gly Pro Glu Leu Gln Gly Asn Ser Thr Ser Ile Ser Thr Leu Arg 
        35                  40                  45              


Thr Ser Cys Leu Leu Gly Cys Ala Val Met Gln Asp Asn Pro Asp Cys 
    50                  55                  60                  


Leu Val Gln Ala Gln Ala Ile Ser Cys Leu Gln Gln Leu His Met Phe 
65                  70                  75                  80  


Ala Pro Arg His Val Asn Leu Ser Ser Leu Val Ser Cys Leu Cys Glu 
                85                  90                  95      


Ile Leu Leu Asp Asn Ser Val Leu Val Asn Leu Cys Ser Pro Tyr Leu 
            100                 105                 110         


Leu Leu Arg Arg Ala Val Leu Ala Cys Leu Arg Gln Leu Val Gln Arg 
        115                 120                 125             


Glu Ala Ala Glu Val Ser Glu His Ala Val Met Leu Ala Lys Asp Ser 
    130                 135                 140                 


Arg Glu Glu Leu Thr Pro Asp Ala Asn Ile Arg Glu Val Gly Leu Glu 
145                 150                 155                 160 


Gly Ala Leu Leu Ile Leu Leu Asp Lys Glu Thr Asp Glu Arg Leu Cys 
                165                 170                 175     


His Asp Ile Lys Glu Thr Leu Asn Tyr Met Leu Thr Ser Met Ala Val 
            180                 185                 190         


Glu Lys Leu Ser Leu Trp Leu 
        195                 


<210>  6421
<211>  208
<212>  PRT
<213>  Homo Sapiens

<400>  6421

Met Glu Ser Gly His Leu Leu Trp Ala Leu Leu Phe Met Gln Ser Leu 
1               5                   10                  15      


Trp Pro Gln Leu Thr Asp Gly Ala Thr Arg Val Tyr Tyr Leu Gly Ile 
            20                  25                  30          


Arg Asp Val Gln Trp Asn Tyr Ala Pro Lys Gly Arg Asn Val Ile Thr 
        35                  40                  45              


Asn Gln Pro Leu Asp Ser Asp Ile Val Ala Ser Ser Phe Leu Lys Ser 
    50                  55                  60                  


Asp Lys Asn Arg Ile Gly Gly Thr Tyr Lys Lys Thr Ile Tyr Lys Glu 
65                  70                  75                  80  


Tyr Lys Asp Asp Ser Tyr Thr Asp Glu Val Ala Gln Pro Ala Trp Leu 
                85                  90                  95      


Gly Phe Leu Gly Pro Val Leu Gln Ala Glu Val Gly Asp Val Ile Leu 
            100                 105                 110         


Ile His Leu Lys Asn Phe Ala Thr Arg Pro Tyr Thr Ile His Pro His 
        115                 120                 125             


Gly Val Phe Tyr Glu Lys Asp Ser Glu Gly Ser Leu Tyr Pro Asp Gly 
    130                 135                 140                 


Ser Ser Gly Pro Leu Lys Ala Asp Asp Ser Val Pro Pro Gly Gly Ser 
145                 150                 155                 160 


His Ile Tyr Asn Trp Thr Ile Pro Glu Gly His Ala Pro Thr Asp Ala 
                165                 170                 175     


Asp Pro Ala Cys Leu Thr Trp Ile Tyr His Ser His Val Asp Ala Pro 
            180                 185                 190         


Arg Asp Ile Ala Thr Gly Leu Ile Gly Pro Leu Ile Thr Cys Lys Arg 
        195                 200                 205             


<210>  6422
<211>  1158
<212>  PRT
<213>  Homo Sapiens

<400>  6422

Met Glu Ser Gly His Leu Leu Trp Ala Leu Leu Phe Met Gln Ser Leu 
1               5                   10                  15      


Trp Pro Gln Leu Thr Asp Gly Ala Thr Arg Val Tyr Tyr Leu Gly Ile 
            20                  25                  30          


Arg Asp Val Gln Trp Asn Tyr Ala Pro Lys Gly Arg Asn Val Ile Thr 
        35                  40                  45              


Asn Gln Pro Leu Asp Ser Asp Ile Val Ala Ser Ser Phe Leu Lys Ser 
    50                  55                  60                  


Asp Lys Asn Arg Ile Gly Gly Thr Tyr Lys Lys Thr Ile Tyr Lys Glu 
65                  70                  75                  80  


Tyr Lys Asp Asp Ser Tyr Thr Asp Glu Val Ala Gln Pro Ala Trp Leu 
                85                  90                  95      


Gly Phe Leu Gly Pro Val Leu Gln Ala Glu Val Gly Asp Val Ile Leu 
            100                 105                 110         


Ile His Leu Lys Asn Phe Ala Thr Arg Pro Tyr Thr Ile His Pro His 
        115                 120                 125             


Gly Val Phe Tyr Glu Lys Asp Ser Glu Gly Ser Leu Tyr Pro Asp Gly 
    130                 135                 140                 


Ser Ser Gly Pro Leu Lys Ala Asp Asp Ser Val Pro Pro Gly Gly Ser 
145                 150                 155                 160 


His Ile Tyr Asn Trp Thr Ile Pro Glu Gly His Ala Pro Thr Asp Ala 
                165                 170                 175     


Asp Pro Ala Cys Leu Thr Trp Ile Tyr His Ser His Val Asp Ala Pro 
            180                 185                 190         


Arg Asp Ile Ala Thr Gly Leu Ile Gly Pro Leu Ile Thr Cys Lys Arg 
        195                 200                 205             


Gly Ala Leu Asp Gly Asn Ser Pro Pro Gln Arg Gln Asp Val Asp His 
    210                 215                 220                 


Asp Phe Phe Leu Leu Phe Ser Val Val Asp Glu Asn Leu Ser Trp His 
225                 230                 235                 240 


Leu Asn Glu Asn Ile Ala Thr Tyr Cys Ser Asp Pro Ala Ser Val Asp 
                245                 250                 255     


Lys Glu Asp Glu Thr Phe Gln Glu Ser Asn Arg Met His Ala Ile Asn 
            260                 265                 270         


Gly Phe Val Phe Gly Asn Leu Pro Glu Leu Asn Met Cys Ala Gln Lys 
        275                 280                 285             


Arg Val Ala Trp His Leu Phe Gly Met Gly Asn Glu Ile Asp Val His 
    290                 295                 300                 


Thr Ala Phe Phe His Gly Gln Met Leu Thr Thr Arg Gly His His Thr 
305                 310                 315                 320 


Asp Val Ala Asn Ile Phe Pro Ala Thr Phe Val Thr Ala Glu Met Val 
                325                 330                 335     


Pro Trp Glu Pro Gly Thr Trp Leu Ile Ser Cys Gln Val Asn Ser His 
            340                 345                 350         


Phe Arg Asp Gly Met Gln Ala Leu Tyr Lys Val Lys Ser Cys Ser Met 
        355                 360                 365             


Ala Pro Pro Val Asp Leu Leu Thr Gly Lys Val Arg Gln Tyr Phe Ile 
    370                 375                 380                 


Glu Ala His Glu Ile Gln Trp Asp Tyr Gly Pro Met Gly His Asp Gly 
385                 390                 395                 400 


Ser Thr Gly Lys Asn Leu Arg Glu Pro Gly Ser Ile Ser Asp Lys Phe 
                405                 410                 415     


Phe Gln Lys Ser Ser Ser Arg Ile Gly Gly Thr Tyr Trp Lys Val Arg 
            420                 425                 430         


Tyr Glu Ala Phe Gln Asp Glu Thr Phe Gln Glu Lys Met His Leu Glu 
        435                 440                 445             


Glu Asp Arg His Leu Gly Ile Leu Gly Pro Val Ile Arg Ala Glu Val 
    450                 455                 460                 


Gly Asp Thr Ile Gln Val Val Phe Tyr Asn Arg Ala Ser Gln Pro Phe 
465                 470                 475                 480 


Ser Met Gln Pro His Gly Val Phe Tyr Glu Lys Asp Tyr Glu Gly Thr 
                485                 490                 495     


Val Tyr Asn Asp Gly Ser Ser Tyr Pro Gly Leu Val Ala Lys Pro Phe 
            500                 505                 510         


Glu Lys Val Thr Tyr Arg Trp Thr Val Pro Pro His Ala Gly Pro Thr 
        515                 520                 525             


Ala Gln Asp Pro Ala Cys Leu Thr Trp Met Tyr Phe Ser Ala Ala Asp 
    530                 535                 540                 


Pro Ile Arg Asp Thr Asn Ser Gly Leu Val Gly Pro Leu Leu Val Cys 
545                 550                 555                 560 


Arg Ala Gly Ala Leu Gly Ala Asp Gly Lys Gln Lys Gly Val Asp Lys 
                565                 570                 575     


Glu Phe Phe Leu Leu Phe Thr Val Leu Asp Glu Asn Lys Ser Trp Tyr 
            580                 585                 590         


Ser Asn Ala Asn Gln Ala Ala Ala Met Leu Asp Phe Arg Leu Leu Ser 
        595                 600                 605             


Glu Asp Ile Glu Gly Phe Gln Asp Ser Asn Arg Met His Ala Ile Asn 
    610                 615                 620                 


Gly Phe Leu Phe Ser Asn Leu Pro Arg Leu Asp Met Cys Lys Gly Asp 
625                 630                 635                 640 


Thr Val Ala Trp His Leu Leu Gly Leu Gly Thr Glu Thr Asp Val His 
                645                 650                 655     


Gly Val Met Phe Gln Gly Asn Thr Val Gln Leu Gln Gly Met Arg Lys 
            660                 665                 670         


Gly Ala Ala Met Leu Phe Pro His Thr Phe Val Met Ala Ile Met Gln 
        675                 680                 685             


Pro Asp Asn Leu Gly Thr Phe Glu Ile Tyr Cys Gln Ala Gly Ser His 
    690                 695                 700                 


Arg Glu Ala Gly Met Arg Ala Ile Tyr Asn Val Ser Gln Cys Pro Gly 
705                 710                 715                 720 


His Gln Ala Thr Pro Arg Gln Arg Tyr Gln Ala Ala Arg Ile Tyr Tyr 
                725                 730                 735     


Ile Met Ala Glu Glu Val Glu Trp Asp Tyr Cys Pro Asp Arg Ser Trp 
            740                 745                 750         


Glu Arg Glu Trp His Asn Gln Ser Glu Lys Asp Ser Tyr Gly Tyr Ile 
        755                 760                 765             


Phe Leu Ser Asn Lys Asp Gly Leu Leu Gly Ser Arg Tyr Lys Lys Ala 
    770                 775                 780                 


Val Phe Arg Glu Tyr Thr Asp Gly Thr Phe Arg Ile Pro Arg Pro Arg 
785                 790                 795                 800 


Thr Gly Pro Glu Glu His Leu Gly Ile Leu Gly Pro Leu Ile Lys Gly 
                805                 810                 815     


Glu Val Gly Asp Ile Leu Thr Val Val Phe Lys Asn Asn Ala Ser Arg 
            820                 825                 830         


Pro Tyr Ser Val His Ala His Gly Val Leu Glu Ser Thr Thr Val Trp 
        835                 840                 845             


Pro Leu Ala Ala Glu Pro Gly Glu Val Val Thr Tyr Gln Trp Asn Ile 
    850                 855                 860                 


Pro Glu Arg Ser Gly Pro Gly Pro Asn Asp Ser Ala Cys Val Ser Trp 
865                 870                 875                 880 


Ile Tyr Tyr Ser Ala Val Asp Pro Ile Lys Asp Met Tyr Ser Gly Leu 
                885                 890                 895     


Val Gly Pro Leu Ala Ile Cys Gln Lys Gly Ile Leu Glu Pro His Gly 
            900                 905                 910         


Gly Arg Ser Asp Met Asp Arg Glu Phe Ala Leu Leu Phe Leu Ile Phe 
        915                 920                 925             


Asp Glu Asn Lys Ser Trp Tyr Leu Glu Glu Asn Val Ala Thr His Gly 
    930                 935                 940                 


Ser Gln Asp Pro Gly Ser Ile Asn Leu Gln Asp Glu Thr Phe Leu Glu 
945                 950                 955                 960 


Ser Asn Lys Met His Ala Ile Asn Gly Lys Leu Tyr Ala Asn Leu Arg 
                965                 970                 975     


Gly Leu Thr Met Tyr Gln Gly Glu Arg Val Ala Trp Tyr Met Leu Ala 
            980                 985                 990         


Met Gly Gln Asp Val Asp Leu His  Thr Ile His Phe His  Ala Glu Ser 
        995                 1000                 1005             


Phe Leu  Tyr Arg Asn Gly Glu  Asn Tyr Arg Ala Asp  Val Val Asp 
    1010                 1015                 1020             


Leu Phe  Pro Gly Thr Phe Glu  Val Val Glu Met Val  Ala Ser Asn 
    1025                 1030                 1035             


Pro Gly  Thr Trp Leu Met His  Cys His Val Thr Asp  His Val His 
    1040                 1045                 1050             


Ala Gly  Met Glu Thr Leu Phe  Thr Val Phe Ser Arg  Thr Glu His 
    1055                 1060                 1065             


Leu Ser  Pro Leu Thr Val Ile  Thr Lys Glu Thr Glu  Lys Ala Val 
    1070                 1075                 1080             


Pro Pro  Arg Asp Ile Glu Glu  Gly Asn Val Lys Met  Leu Gly Met 
    1085                 1090                 1095             


Gln Ile  Pro Ile Lys Asn Val  Glu Met Leu Ala Ser  Val Leu Val 
    1100                 1105                 1110             


Ala Ile  Ser Val Thr Leu Leu  Leu Val Val Leu Ala  Leu Gly Gly 
    1115                 1120                 1125             


Val Val  Trp Tyr Gln His Arg  Gln Arg Lys Leu Arg  Arg Asn Arg 
    1130                 1135                 1140             


Arg Ser  Ile Leu Asp Asp Ser  Phe Lys Leu Leu Ser  Phe Lys Gln 
    1145                 1150                 1155             


<210>  6423
<211>  811
<212>  PRT
<213>  Homo Sapiens

<400>  6423

Met Glu Ser Gly His Leu Leu Trp Ala Leu Leu Phe Met Gln Ser Leu 
1               5                   10                  15      


Trp Pro Gln Leu Thr Asp Gly Ala Thr Arg Val Tyr Tyr Leu Gly Ile 
            20                  25                  30          


Arg Asp Val Gln Trp Asn Tyr Ala Pro Lys Gly Arg Asn Val Ile Thr 
        35                  40                  45              


Asn Gln Pro Leu Asp Ser Asp Ile Val Ala Ser Ser Phe Leu Lys Ser 
    50                  55                  60                  


Asp Lys Asn Arg Ile Gly Gly Thr Tyr Lys Lys Thr Ile Tyr Lys Glu 
65                  70                  75                  80  


Tyr Lys Asp Asp Ser Tyr Thr Asp Glu Val Ala Gln Pro Ala Trp Leu 
                85                  90                  95      


Gly Phe Leu Gly Pro Val Leu Gln Ala Glu Val Gly Asp Val Ile Leu 
            100                 105                 110         


Ile His Leu Lys Asn Phe Ala Thr Arg Pro Tyr Thr Ile His Pro His 
        115                 120                 125             


Gly Val Phe Tyr Glu Lys Asp Ser Glu Gly Ser Leu Tyr Pro Asp Gly 
    130                 135                 140                 


Ser Ser Gly Pro Leu Lys Ala Asp Asp Ser Val Pro Pro Gly Gly Ser 
145                 150                 155                 160 


His Ile Tyr Asn Trp Thr Ile Pro Glu Gly His Ala Pro Thr Asp Ala 
                165                 170                 175     


Asp Pro Ala Cys Leu Thr Trp Ile Tyr His Ser His Val Asp Ala Pro 
            180                 185                 190         


Arg Asp Ile Ala Thr Gly Leu Ile Gly Pro Leu Ile Thr Cys Lys Arg 
        195                 200                 205             


Gly Ala Leu Asp Gly Asn Ser Pro Pro Gln Arg Gln Asp Val Asp His 
    210                 215                 220                 


Asp Phe Phe Leu Leu Phe Ser Val Val Asp Glu Asn Leu Ser Trp His 
225                 230                 235                 240 


Leu Asn Glu Asn Ile Ala Thr Tyr Cys Ser Asp Pro Ala Ser Val Asp 
                245                 250                 255     


Lys Glu Asp Glu Thr Phe Gln Glu Ser Asn Arg Met His Ala Ile Asn 
            260                 265                 270         


Gly Phe Val Phe Gly Asn Leu Pro Glu Leu Asn Met Cys Ala Gln Lys 
        275                 280                 285             


Arg Val Ala Trp His Leu Phe Gly Met Gly Asn Glu Ile Asp Val His 
    290                 295                 300                 


Thr Ala Phe Phe His Gly Gln Met Leu Thr Thr Arg Gly His His Thr 
305                 310                 315                 320 


Asp Val Ala Asn Ile Phe Pro Ala Thr Phe Val Thr Ala Glu Met Val 
                325                 330                 335     


Pro Trp Glu Pro Gly Thr Trp Leu Ile Ser Cys Gln Val Asn Ser His 
            340                 345                 350         


Phe Arg Asp Gly Met Gln Ala Leu Tyr Lys Val Lys Ser Cys Ser Met 
        355                 360                 365             


Ala Pro Pro Val Asp Leu Leu Thr Gly Lys Val Arg Gln Tyr Phe Ile 
    370                 375                 380                 


Glu Ala His Glu Ile Gln Trp Asp Tyr Gly Pro Met Gly His Asp Gly 
385                 390                 395                 400 


Ser Thr Gly Lys Asn Leu Arg Glu Pro Gly Ser Ile Ser Asp Lys Phe 
                405                 410                 415     


Phe Gln Lys Ser Ser Ser Arg Ile Gly Gly Thr Tyr Trp Lys Val Arg 
            420                 425                 430         


Tyr Glu Ala Phe Gln Asp Glu Thr Phe Gln Glu Lys Met His Leu Glu 
        435                 440                 445             


Glu Asp Arg His Leu Gly Ile Leu Gly Pro Val Ile Arg Ala Glu Val 
    450                 455                 460                 


Gly Asp Thr Ile Gln Val Val Phe Tyr Asn Arg Ala Ser Gln Pro Phe 
465                 470                 475                 480 


Ser Met Gln Pro His Gly Val Phe Tyr Glu Lys Asp Tyr Glu Gly Thr 
                485                 490                 495     


Val Tyr Asn Asp Asp Pro Ile Arg Asp Thr Asn Ser Gly Leu Val Gly 
            500                 505                 510         


Pro Leu Leu Val Cys Arg Ala Gly Ala Leu Gly Ala Asp Gly Lys Gln 
        515                 520                 525             


Lys Gly Val Asp Lys Glu Phe Phe Leu Leu Phe Thr Val Leu Asp Glu 
    530                 535                 540                 


Asn Lys Ser Trp Tyr Ser Asn Ala Asn Gln Ala Ala Ala Met Leu Asp 
545                 550                 555                 560 


Phe Arg Leu Leu Ser Glu Asp Ile Glu Gly Phe Gln Asp Ser Asn Arg 
                565                 570                 575     


Met His Ala Ile Asn Gly Phe Leu Phe Ser Asn Leu Pro Arg Leu Asp 
            580                 585                 590         


Met Cys Lys Gly Asp Thr Val Ala Trp His Leu Leu Gly Leu Gly Thr 
        595                 600                 605             


Glu Thr Asp Val His Gly Val Met Phe Gln Gly Asn Thr Val Gln Leu 
    610                 615                 620                 


Gln Gly Met Arg Lys Gly Ala Ala Met Leu Phe Pro His Thr Phe Val 
625                 630                 635                 640 


Met Ala Ile Met Gln Pro Asp Asn Leu Gly Thr Phe Glu Ile Tyr Cys 
                645                 650                 655     


Gln Ala Gly Ser His Arg Glu Ala Gly Met Arg Ala Ile Tyr Asn Val 
            660                 665                 670         


Ser Gln Cys Pro Gly His Gln Ala Thr Pro Arg Gln Arg Tyr Gln Ala 
        675                 680                 685             


Ala Arg Ile Tyr Tyr Ile Met Ala Glu Glu Val Glu Trp Asp Tyr Cys 
    690                 695                 700                 


Pro Asp Arg Ser Trp Glu Arg Glu Trp His Asn Gln Ser Glu Lys Asp 
705                 710                 715                 720 


Ser Tyr Gly Tyr Ile Phe Leu Ser Asn Lys Asp Gly Leu Leu Gly Ser 
                725                 730                 735     


Arg Tyr Lys Lys Ala Val Phe Arg Glu Tyr Thr Asp Gly Thr Phe Arg 
            740                 745                 750         


Ile Pro Arg Pro Arg Thr Gly Pro Glu Glu His Leu Gly Ile Leu Gly 
        755                 760                 765             


Pro Leu Ile Lys Gly Glu Val Gly Asp Ile Leu Thr Val Val Phe Lys 
    770                 775                 780                 


Asn Asn Ala Ser Arg Pro Tyr Ser Val His Ala His Gly Val Leu Glu 
785                 790                 795                 800 


Ser Thr Thr Val Trp Pro Leu Ala Ala Glu Pro 
                805                 810     


<210>  6424
<211>  891
<212>  PRT
<213>  Homo Sapiens

<400>  6424

Met His Ala Ile Asn Gly Phe Val Phe Gly Asn Leu Pro Glu Leu Asn 
1               5                   10                  15      


Met Cys Ala Gln Lys Arg Val Ala Trp His Leu Phe Gly Met Gly Asn 
            20                  25                  30          


Glu Ile Asp Val His Thr Ala Phe Phe His Gly Gln Met Leu Thr Thr 
        35                  40                  45              


Arg Gly His His Thr Asp Val Ala Asn Ile Phe Pro Ala Thr Phe Val 
    50                  55                  60                  


Thr Ala Glu Met Val Pro Trp Glu Pro Gly Thr Trp Leu Ile Ser Cys 
65                  70                  75                  80  


Gln Val Asn Ser His Phe Arg Asp Gly Met Gln Ala Leu Tyr Lys Val 
                85                  90                  95      


Lys Ser Cys Ser Met Ala Pro Pro Val Asp Leu Leu Thr Gly Lys Val 
            100                 105                 110         


Arg Gln Tyr Phe Ile Glu Ala His Glu Ile Gln Trp Asp Tyr Gly Pro 
        115                 120                 125             


Met Gly His Asp Gly Ser Thr Gly Lys Asn Leu Arg Glu Pro Gly Ser 
    130                 135                 140                 


Ile Ser Asp Lys Phe Phe Gln Lys Ser Ser Ser Arg Ile Gly Gly Thr 
145                 150                 155                 160 


Tyr Trp Lys Val Arg Tyr Glu Ala Phe Gln Asp Glu Thr Phe Gln Glu 
                165                 170                 175     


Lys Met His Leu Glu Glu Asp Arg His Leu Gly Ile Leu Gly Pro Val 
            180                 185                 190         


Ile Arg Ala Glu Val Gly Asp Thr Ile Gln Val Val Phe Tyr Asn Arg 
        195                 200                 205             


Ala Ser Gln Pro Phe Ser Met Gln Pro His Gly Val Phe Tyr Glu Lys 
    210                 215                 220                 


Asp Tyr Glu Gly Thr Val Tyr Asn Asp Gly Ser Ser Tyr Pro Gly Leu 
225                 230                 235                 240 


Val Ala Lys Pro Phe Glu Lys Val Thr Tyr Arg Trp Thr Val Pro Pro 
                245                 250                 255     


His Ala Gly Pro Thr Ala Gln Asp Pro Ala Cys Leu Thr Trp Met Tyr 
            260                 265                 270         


Phe Ser Ala Ala Asp Pro Ile Arg Asp Thr Asn Ser Gly Leu Val Gly 
        275                 280                 285             


Pro Leu Leu Val Cys Arg Ala Gly Ala Leu Gly Ala Asp Gly Lys Gln 
    290                 295                 300                 


Lys Gly Val Asp Lys Glu Phe Phe Leu Leu Phe Thr Val Leu Asp Glu 
305                 310                 315                 320 


Asn Lys Ser Trp Tyr Ser Asn Ala Asn Gln Ala Ala Ala Met Leu Asp 
                325                 330                 335     


Phe Arg Leu Leu Ser Glu Asp Ile Glu Gly Phe Gln Asp Ser Asn Arg 
            340                 345                 350         


Met His Ala Ile Asn Gly Phe Leu Phe Ser Asn Leu Pro Arg Leu Asp 
        355                 360                 365             


Met Cys Lys Gly Asp Thr Val Ala Trp His Leu Leu Gly Leu Gly Thr 
    370                 375                 380                 


Glu Thr Asp Val His Gly Val Met Phe Gln Gly Asn Thr Val Gln Leu 
385                 390                 395                 400 


Gln Gly Met Arg Lys Gly Ala Ala Met Leu Phe Pro His Thr Phe Val 
                405                 410                 415     


Met Ala Ile Met Gln Pro Asp Asn Leu Gly Thr Phe Glu Ile Tyr Cys 
            420                 425                 430         


Gln Ala Gly Ser His Arg Glu Ala Gly Met Arg Ala Ile Tyr Asn Val 
        435                 440                 445             


Ser Gln Cys Pro Gly His Gln Ala Thr Pro Arg Gln Arg Tyr Gln Ala 
    450                 455                 460                 


Ala Arg Ile Tyr Tyr Ile Met Ala Glu Glu Val Glu Trp Asp Tyr Cys 
465                 470                 475                 480 


Pro Asp Arg Ser Trp Glu Arg Glu Trp His Asn Gln Ser Glu Lys Asp 
                485                 490                 495     


Ser Tyr Gly Tyr Ile Phe Leu Ser Asn Lys Asp Gly Leu Leu Gly Ser 
            500                 505                 510         


Arg Tyr Lys Lys Ala Val Phe Arg Glu Tyr Thr Asp Gly Thr Phe Arg 
        515                 520                 525             


Ile Pro Arg Pro Arg Thr Gly Pro Glu Glu His Leu Gly Ile Leu Gly 
    530                 535                 540                 


Pro Leu Ile Lys Gly Glu Val Gly Asp Ile Leu Thr Val Val Phe Lys 
545                 550                 555                 560 


Asn Asn Ala Ser Arg Pro Tyr Ser Val His Ala His Gly Val Leu Glu 
                565                 570                 575     


Ser Thr Thr Val Trp Pro Leu Ala Ala Glu Pro Gly Glu Val Val Thr 
            580                 585                 590         


Tyr Gln Trp Asn Ile Pro Glu Arg Ser Gly Pro Gly Pro Asn Asp Ser 
        595                 600                 605             


Ala Cys Val Ser Trp Ile Tyr Tyr Ser Ala Val Asp Pro Ile Lys Asp 
    610                 615                 620                 


Met Tyr Ser Gly Leu Val Gly Pro Leu Ala Ile Cys Gln Lys Gly Ile 
625                 630                 635                 640 


Leu Glu Pro His Gly Gly Arg Ser Asp Met Asp Arg Glu Phe Ala Leu 
                645                 650                 655     


Leu Phe Leu Ile Phe Asp Glu Asn Lys Ser Trp Tyr Leu Glu Glu Asn 
            660                 665                 670         


Val Ala Thr His Gly Ser Gln Asp Pro Gly Ser Ile Asn Leu Gln Asp 
        675                 680                 685             


Glu Thr Phe Leu Glu Ser Asn Lys Met His Ala Ile Asn Gly Lys Leu 
    690                 695                 700                 


Tyr Ala Asn Leu Arg Gly Leu Thr Met Tyr Gln Gly Glu Arg Val Ala 
705                 710                 715                 720 


Trp Tyr Met Leu Ala Met Gly Gln Asp Val Asp Leu His Thr Ile His 
                725                 730                 735     


Phe His Ala Glu Ser Phe Leu Tyr Arg Asn Gly Glu Asn Tyr Arg Ala 
            740                 745                 750         


Asp Val Val Asp Leu Phe Pro Gly Thr Phe Glu Val Val Glu Met Val 
        755                 760                 765             


Ala Ser Asn Pro Gly Thr Trp Leu Met His Cys His Val Thr Asp His 
    770                 775                 780                 


Val His Ala Gly Met Glu Thr Leu Phe Thr Val Phe Ser Arg Thr Glu 
785                 790                 795                 800 


His Leu Ser Pro Leu Thr Val Ile Thr Lys Glu Thr Glu Lys Ala Val 
                805                 810                 815     


Pro Pro Arg Asp Ile Glu Glu Gly Asn Val Lys Met Leu Gly Met Gln 
            820                 825                 830         


Ile Pro Ile Lys Asn Val Glu Met Leu Ala Ser Val Leu Val Ala Ile 
        835                 840                 845             


Ser Val Thr Leu Leu Leu Val Val Leu Ala Leu Gly Gly Val Val Trp 
    850                 855                 860                 


Tyr Gln His Arg Gln Arg Lys Leu Arg Arg Asn Arg Arg Ser Ile Leu 
865                 870                 875                 880 


Asp Asp Ser Phe Lys Leu Leu Ser Phe Lys Gln 
                885                 890     


<210>  6425
<211>  1212
<212>  PRT
<213>  Homo Sapiens

<400>  6425

Met Thr Gln Thr Leu Pro Tyr His Leu Ser Leu Leu Asn Val Leu Phe 
1               5                   10                  15      


Pro Gly Pro Cys Ser Arg His Phe Lys Phe Arg Arg Gly Lys Cys Ala 
            20                  25                  30          


Gln Pro Ala Trp Arg Lys Val Ser Ala Pro Ser Gln Asp Leu Leu Ile 
        35                  40                  45              


Thr Lys Val Met Trp Ala Met Glu Ser Gly His Leu Leu Trp Ala Leu 
    50                  55                  60                  


Leu Phe Met Gln Ser Leu Trp Pro Gln Leu Thr Asp Gly Ala Thr Arg 
65                  70                  75                  80  


Val Tyr Tyr Leu Gly Ile Arg Asp Val Gln Trp Asn Tyr Ala Pro Lys 
                85                  90                  95      


Gly Arg Asn Val Ile Thr Asn Gln Pro Leu Asp Ser Asp Ile Val Ala 
            100                 105                 110         


Ser Ser Phe Leu Lys Ser Asp Lys Asn Arg Ile Gly Gly Thr Tyr Lys 
        115                 120                 125             


Lys Thr Ile Tyr Lys Glu Tyr Lys Asp Asp Ser Tyr Thr Asp Glu Val 
    130                 135                 140                 


Ala Gln Pro Ala Trp Leu Gly Phe Leu Gly Pro Val Leu Gln Ala Glu 
145                 150                 155                 160 


Val Gly Asp Val Ile Leu Ile His Leu Lys Asn Phe Ala Thr Arg Pro 
                165                 170                 175     


Tyr Thr Ile His Pro His Gly Val Phe Tyr Glu Lys Asp Ser Glu Gly 
            180                 185                 190         


Ser Leu Tyr Pro Asp Gly Ser Ser Gly Pro Leu Lys Ala Asp Asp Ser 
        195                 200                 205             


Val Pro Pro Gly Gly Ser His Ile Tyr Asn Trp Thr Ile Pro Glu Gly 
    210                 215                 220                 


His Ala Pro Thr Asp Ala Asp Pro Ala Cys Leu Thr Trp Ile Tyr His 
225                 230                 235                 240 


Ser His Val Asp Ala Pro Arg Asp Ile Ala Thr Gly Leu Ile Gly Pro 
                245                 250                 255     


Leu Ile Thr Cys Lys Arg Gly Ala Leu Asp Gly Asn Ser Pro Pro Gln 
            260                 265                 270         


Arg Gln Asp Val Asp His Asp Phe Phe Leu Leu Phe Ser Val Val Asp 
        275                 280                 285             


Glu Asn Leu Ser Trp His Leu Asn Glu Asn Ile Ala Thr Tyr Cys Ser 
    290                 295                 300                 


Asp Pro Ala Ser Val Asp Lys Glu Asp Glu Thr Phe Gln Glu Ser Asn 
305                 310                 315                 320 


Arg Met His Ala Ile Asn Gly Phe Val Phe Gly Asn Leu Pro Glu Leu 
                325                 330                 335     


Asn Met Cys Ala Gln Lys Arg Val Ala Trp His Leu Phe Gly Met Gly 
            340                 345                 350         


Asn Glu Ile Asp Val His Thr Ala Phe Phe His Gly Gln Met Leu Thr 
        355                 360                 365             


Thr Arg Gly His His Thr Asp Val Ala Asn Ile Phe Pro Ala Thr Phe 
    370                 375                 380                 


Val Thr Ala Glu Met Val Pro Trp Glu Pro Gly Thr Trp Leu Ile Ser 
385                 390                 395                 400 


Cys Gln Val Asn Ser His Phe Arg Asp Gly Met Gln Ala Leu Tyr Lys 
                405                 410                 415     


Val Lys Ser Cys Ser Met Ala Pro Pro Val Asp Leu Leu Thr Gly Lys 
            420                 425                 430         


Val Arg Gln Tyr Phe Ile Glu Ala His Glu Ile Gln Trp Asp Tyr Gly 
        435                 440                 445             


Pro Met Gly His Asp Gly Ser Thr Gly Lys Asn Leu Arg Glu Pro Gly 
    450                 455                 460                 


Ser Ile Ser Asp Lys Phe Phe Gln Lys Ser Ser Ser Arg Ile Gly Gly 
465                 470                 475                 480 


Thr Tyr Trp Lys Val Arg Tyr Glu Ala Phe Gln Asp Glu Thr Phe Gln 
                485                 490                 495     


Glu Lys Met His Leu Glu Glu Asp Arg His Leu Gly Ile Leu Gly Pro 
            500                 505                 510         


Val Ile Arg Ala Glu Val Gly Asp Thr Ile Gln Val Val Phe Tyr Asn 
        515                 520                 525             


Arg Ala Ser Gln Pro Phe Ser Met Gln Pro His Gly Val Phe Tyr Glu 
    530                 535                 540                 


Lys Asp Tyr Glu Gly Thr Val Tyr Asn Asp Gly Ser Ser Tyr Pro Gly 
545                 550                 555                 560 


Leu Val Ala Lys Pro Phe Glu Lys Val Thr Tyr Arg Trp Thr Val Pro 
                565                 570                 575     


Pro His Ala Gly Pro Thr Ala Gln Asp Pro Ala Cys Leu Thr Trp Met 
            580                 585                 590         


Tyr Phe Ser Ala Ala Asp Pro Ile Arg Asp Thr Asn Ser Gly Leu Val 
        595                 600                 605             


Gly Pro Leu Leu Val Cys Arg Ala Gly Ala Leu Gly Ala Asp Gly Lys 
    610                 615                 620                 


Gln Lys Gly Val Asp Lys Glu Phe Phe Leu Leu Phe Thr Val Leu Asp 
625                 630                 635                 640 


Glu Asn Lys Ser Trp Tyr Ser Asn Ala Asn Gln Ala Ala Ala Met Leu 
                645                 650                 655     


Asp Phe Arg Leu Leu Ser Glu Asp Ile Glu Gly Phe Gln Asp Ser Asn 
            660                 665                 670         


Arg Met His Ala Ile Asn Gly Phe Leu Phe Ser Asn Leu Pro Arg Leu 
        675                 680                 685             


Asp Met Cys Lys Gly Asp Thr Val Ala Trp His Leu Leu Gly Leu Gly 
    690                 695                 700                 


Thr Glu Thr Asp Val His Gly Val Met Phe Gln Gly Asn Thr Val Gln 
705                 710                 715                 720 


Leu Gln Gly Met Arg Lys Gly Ala Ala Met Leu Phe Pro His Thr Phe 
                725                 730                 735     


Val Met Ala Ile Met Gln Pro Asp Asn Leu Gly Thr Phe Glu Ile Tyr 
            740                 745                 750         


Cys Gln Ala Gly Ser His Arg Glu Ala Gly Met Arg Ala Ile Tyr Asn 
        755                 760                 765             


Val Ser Gln Cys Pro Gly His Gln Ala Thr Pro Arg Gln Arg Tyr Gln 
    770                 775                 780                 


Ala Ala Arg Ile Tyr Tyr Ile Met Ala Glu Glu Val Glu Trp Asp Tyr 
785                 790                 795                 800 


Cys Pro Asp Arg Ser Trp Glu Arg Glu Trp His Asn Gln Ser Glu Lys 
                805                 810                 815     


Asp Ser Tyr Gly Tyr Ile Phe Leu Ser Asn Lys Asp Gly Leu Leu Gly 
            820                 825                 830         


Ser Arg Tyr Lys Lys Ala Val Phe Arg Glu Tyr Thr Asp Gly Thr Phe 
        835                 840                 845             


Arg Ile Pro Arg Pro Arg Thr Gly Pro Glu Glu His Leu Gly Ile Leu 
    850                 855                 860                 


Gly Pro Leu Ile Lys Gly Glu Val Gly Asp Ile Leu Thr Val Val Phe 
865                 870                 875                 880 


Lys Asn Asn Ala Ser Arg Pro Tyr Ser Val His Ala His Gly Val Leu 
                885                 890                 895     


Glu Ser Thr Thr Val Trp Pro Leu Ala Ala Glu Pro Gly Glu Val Val 
            900                 905                 910         


Thr Tyr Gln Trp Asn Ile Pro Glu Arg Ser Gly Pro Gly Pro Asn Asp 
        915                 920                 925             


Ser Ala Cys Val Ser Trp Ile Tyr Tyr Ser Ala Val Asp Pro Ile Lys 
    930                 935                 940                 


Asp Met Tyr Ser Gly Leu Val Gly Pro Leu Ala Ile Cys Gln Lys Gly 
945                 950                 955                 960 


Ile Leu Glu Pro His Gly Gly Arg Ser Asp Met Asp Arg Glu Phe Ala 
                965                 970                 975     


Leu Leu Phe Leu Ile Phe Asp Glu Asn Lys Ser Trp Tyr Leu Glu Glu 
            980                 985                 990         


Asn Val Ala Thr His Gly Ser Gln  Asp Pro Gly Ser Ile  Asn Leu Gln 
        995                 1000                 1005             


Asp Glu  Thr Phe Leu Glu Ser  Asn Lys Met His Ala  Ile Asn Gly 
    1010                 1015                 1020             


Lys Leu  Tyr Ala Asn Leu Arg  Gly Leu Thr Met Tyr  Gln Gly Glu 
    1025                 1030                 1035             


Arg Val  Ala Trp Tyr Met Leu  Ala Met Gly Gln Asp  Val Asp Leu 
    1040                 1045                 1050             


His Thr  Ile His Phe His Ala  Glu Ser Phe Leu Tyr  Arg Asn Gly 
    1055                 1060                 1065             


Glu Asn  Tyr Arg Ala Asp Val  Val Asp Leu Phe Pro  Gly Thr Phe 
    1070                 1075                 1080             


Glu Val  Val Glu Met Val Ala  Ser Asn Pro Gly Thr  Trp Leu Met 
    1085                 1090                 1095             


His Cys  His Val Thr Asp His  Val His Ala Gly Met  Glu Thr Leu 
    1100                 1105                 1110             


Phe Thr  Val Phe Ser Arg Thr  Glu His Leu Ser Pro  Leu Thr Val 
    1115                 1120                 1125             


Ile Thr  Lys Glu Thr Glu Lys  Ala Val Pro Pro Arg  Asp Ile Glu 
    1130                 1135                 1140             


Glu Gly  Asn Val Lys Met Leu  Gly Met Gln Ile Pro  Ile Lys Asn 
    1145                 1150                 1155             


Val Glu  Met Leu Ala Ser Val  Leu Val Ala Ile Ser  Val Thr Leu 
    1160                 1165                 1170             


Leu Leu  Val Val Leu Ala Leu  Gly Gly Val Val Trp  Tyr Gln His 
    1175                 1180                 1185             


Arg Gln  Arg Lys Leu Arg Arg  Asn Arg Arg Ser Ile  Leu Asp Asp 
    1190                 1195                 1200             


Ser Phe  Lys Leu Leu Ser Phe  Lys Gln 
    1205                 1210         


<210>  6426
<211>  1160
<212>  PRT
<213>  Homo Sapiens

<400>  6426

Met Trp Ala Met Glu Ser Gly His Leu Leu Trp Ala Leu Leu Phe Met 
1               5                   10                  15      


Gln Ser Leu Trp Pro Gln Leu Thr Asp Gly Ala Thr Arg Val Tyr Tyr 
            20                  25                  30          


Leu Gly Ile Arg Asp Val Gln Trp Asn Tyr Ala Pro Lys Gly Arg Asn 
        35                  40                  45              


Val Ile Thr Asn Gln Pro Leu Asp Ser Asp Ile Val Ala Ser Ser Phe 
    50                  55                  60                  


Leu Lys Ser Asp Lys Asn Arg Ile Gly Gly Thr Tyr Lys Lys Thr Ile 
65                  70                  75                  80  


Tyr Lys Glu Tyr Lys Asp Asp Ser Tyr Thr Asp Glu Val Ala Gln Pro 
                85                  90                  95      


Ala Trp Leu Gly Phe Leu Gly Pro Val Leu Gln Ala Glu Val Gly Asp 
            100                 105                 110         


Val Ile Leu Ile His Leu Lys Asn Phe Ala Thr Arg Pro Tyr Thr Ile 
        115                 120                 125             


His Pro His Gly Val Phe Tyr Glu Lys Asp Ser Glu Gly Ser Leu Tyr 
    130                 135                 140                 


Pro Asp Gly Ser Ser Gly Pro Leu Lys Ala Asp Asp Ser Val Pro Pro 
145                 150                 155                 160 


Gly Gly Ser His Ile Tyr Asn Trp Thr Ile Pro Glu Gly His Ala Pro 
                165                 170                 175     


Thr Asp Ala Asp Pro Ala Cys Leu Thr Trp Ile Tyr His Ser His Val 
            180                 185                 190         


Asp Ala Pro Arg Asp Ile Ala Thr Gly Leu Ile Gly Pro Leu Ile Thr 
        195                 200                 205             


Cys Lys Arg Gly Ala Leu Asp Gly Asn Ser Pro Pro Gln Arg Gln Asp 
    210                 215                 220                 


Val Asp His Asp Phe Phe Leu Leu Phe Ser Val Val Asp Glu Asn Leu 
225                 230                 235                 240 


Ser Trp His Leu Asn Glu Asn Ile Ala Thr Tyr Cys Ser Asp Pro Ala 
                245                 250                 255     


Ser Val Asp Lys Glu Asp Glu Thr Phe Gln Glu Ser Asn Arg Met His 
            260                 265                 270         


Ala Ile Asn Gly Phe Val Phe Gly Asn Leu Pro Glu Leu Asn Met Cys 
        275                 280                 285             


Ala Gln Lys Arg Val Ala Trp His Leu Phe Gly Met Gly Asn Glu Ile 
    290                 295                 300                 


Asp Val His Thr Ala Phe Phe His Gly Gln Met Leu Thr Thr Arg Gly 
305                 310                 315                 320 


His His Thr Asp Val Ala Asn Ile Phe Pro Ala Thr Phe Val Thr Ala 
                325                 330                 335     


Glu Met Val Pro Trp Glu Pro Gly Thr Trp Leu Ile Ser Cys Gln Val 
            340                 345                 350         


Asn Ser His Phe Arg Asp Gly Met Gln Ala Leu Tyr Lys Val Lys Ser 
        355                 360                 365             


Cys Ser Met Ala Pro Pro Val Asp Leu Leu Thr Gly Lys Val Arg Gln 
    370                 375                 380                 


Tyr Phe Ile Glu Ala His Glu Ile Gln Trp Asp Tyr Gly Pro Met Gly 
385                 390                 395                 400 


His Asp Gly Ser Thr Gly Lys Asn Leu Arg Glu Pro Gly Ser Ile Ser 
                405                 410                 415     


Asp Lys Phe Phe Gln Lys Ser Ser Ser Arg Ile Gly Gly Thr Tyr Trp 
            420                 425                 430         


Lys Val Arg Tyr Glu Ala Phe Gln Asp Glu Thr Phe Gln Glu Lys Met 
        435                 440                 445             


His Leu Glu Glu Asp Arg His Leu Gly Ile Leu Gly Pro Val Ile Arg 
    450                 455                 460                 


Ala Glu Val Gly Asp Thr Ile Gln Val Val Phe Tyr Asn Arg Ala Ser 
465                 470                 475                 480 


Gln Pro Phe Ser Met Gln Pro His Gly Val Phe Tyr Glu Lys Asp Tyr 
                485                 490                 495     


Glu Gly Thr Val Tyr Asn Asp Gly Ser Ser Tyr Pro Gly Leu Val Ala 
            500                 505                 510         


Lys Pro Phe Glu Lys Val Thr Tyr Arg Trp Thr Val Pro Pro His Ala 
        515                 520                 525             


Gly Pro Thr Ala Gln Asp Pro Ala Cys Leu Thr Trp Met Tyr Phe Ser 
    530                 535                 540                 


Ala Ala Asp Pro Ile Arg Asp Thr Asn Ser Gly Leu Val Gly Pro Leu 
545                 550                 555                 560 


Leu Val Cys Arg Ala Gly Ala Leu Gly Ala Asp Gly Lys Gln Lys Gly 
                565                 570                 575     


Val Asp Lys Glu Phe Phe Leu Leu Phe Thr Val Leu Asp Glu Asn Lys 
            580                 585                 590         


Ser Trp Tyr Ser Asn Ala Asn Gln Ala Ala Ala Met Leu Asp Phe Arg 
        595                 600                 605             


Leu Leu Ser Glu Asp Ile Glu Gly Phe Gln Asp Ser Asn Arg Met His 
    610                 615                 620                 


Ala Ile Asn Gly Phe Leu Phe Ser Asn Leu Pro Arg Leu Asp Met Cys 
625                 630                 635                 640 


Lys Gly Asp Thr Val Ala Trp His Leu Leu Gly Leu Gly Thr Glu Thr 
                645                 650                 655     


Asp Val His Gly Val Met Phe Gln Gly Asn Thr Val Gln Leu Gln Gly 
            660                 665                 670         


Met Arg Lys Gly Ala Ala Met Leu Phe Pro His Thr Phe Val Met Ala 
        675                 680                 685             


Ile Met Gln Pro Asp Asn Leu Gly Thr Phe Glu Ile Tyr Cys Gln Ala 
    690                 695                 700                 


Gly Ser His Arg Glu Ala Gly Met Arg Ala Ile Tyr Asn Val Ser Gln 
705                 710                 715                 720 


Cys Pro Gly His Gln Ala Thr Pro Arg Gln Arg Tyr Gln Ala Ala Arg 
                725                 730                 735     


Ile Tyr Tyr Ile Met Ala Glu Glu Val Glu Trp Asp Tyr Cys Pro Asp 
            740                 745                 750         


Arg Ser Trp Glu Arg Glu Trp His Asn Gln Ser Glu Lys Asp Ser Tyr 
        755                 760                 765             


Gly Tyr Ile Phe Leu Ser Asn Lys Asp Gly Leu Leu Gly Ser Arg Tyr 
    770                 775                 780                 


Lys Lys Ala Val Phe Arg Glu Tyr Thr Asp Gly Thr Phe Arg Ile Pro 
785                 790                 795                 800 


Arg Pro Arg Thr Gly Pro Glu Glu His Leu Gly Ile Leu Gly Pro Leu 
                805                 810                 815     


Ile Lys Gly Glu Val Gly Asp Ile Leu Thr Val Val Phe Lys Asn Asn 
            820                 825                 830         


Ala Ser Arg Pro Tyr Ser Val His Ala His Gly Val Leu Glu Ser Thr 
        835                 840                 845             


Thr Val Trp Pro Leu Ala Ala Glu Pro Gly Glu Val Val Thr Tyr Gln 
    850                 855                 860                 


Trp Asn Ile Pro Glu Arg Ser Gly Pro Gly Pro Asn Asp Ser Ala Cys 
865                 870                 875                 880 


Val Ser Trp Ile Tyr Tyr Ser Ala Val Asp Pro Ile Lys Asp Met Tyr 
                885                 890                 895     


Ser Gly Leu Val Gly Pro Leu Ala Ile Cys Gln Lys Gly Ile Leu Glu 
            900                 905                 910         


Pro His Gly Gly Arg Ser Asp Met Asp Arg Glu Phe Ala Leu Leu Phe 
        915                 920                 925             


Leu Ile Phe Asp Glu Asn Lys Ser Trp Tyr Leu Glu Glu Asn Val Ala 
    930                 935                 940                 


Thr His Gly Ser Gln Asp Pro Gly Ser Ile Asn Leu Gln Asp Glu Thr 
945                 950                 955                 960 


Phe Leu Glu Ser Asn Lys Met His Ala Ile Asn Gly Lys Leu Tyr Ala 
                965                 970                 975     


Asn Leu Arg Gly Leu Thr Met Tyr Gln Gly Glu Arg Val Ala Trp Tyr 
            980                 985                 990         


Met Leu Ala Met Gly Gln Asp Val  Asp Leu His Thr Ile  His Phe His 
        995                 1000                 1005             


Ala Glu  Ser Phe Leu Tyr Arg  Asn Gly Glu Asn Tyr  Arg Ala Asp 
    1010                 1015                 1020             


Val Val  Asp Leu Phe Pro Gly  Thr Phe Glu Val Val  Glu Met Val 
    1025                 1030                 1035             


Ala Ser  Asn Pro Gly Thr Trp  Leu Met His Cys His  Val Thr Asp 
    1040                 1045                 1050             


His Val  His Ala Gly Met Glu  Thr Leu Phe Thr Val  Phe Ser Arg 
    1055                 1060                 1065             


Thr Glu  His Leu Ser Pro Leu  Thr Val Ile Thr Lys  Glu Thr Glu 
    1070                 1075                 1080             


Lys Val  Pro Pro Arg Asp Ile  Glu Glu Gly Asn Val  Lys Met Leu 
    1085                 1090                 1095             


Gly Met  Gln Ile Pro Ile Lys  Asn Val Glu Met Leu  Ala Ser Val 
    1100                 1105                 1110             


Leu Val  Ala Ile Ser Val Thr  Leu Leu Leu Val Val  Leu Ala Leu 
    1115                 1120                 1125             


Gly Gly  Val Val Trp Tyr Gln  His Arg Gln Arg Lys  Leu Arg Arg 
    1130                 1135                 1140             


Asn Arg  Arg Ser Ile Leu Asp  Asp Ser Phe Lys Leu  Leu Ser Phe 
    1145                 1150                 1155             


Lys Gln  
    1160 


<210>  6427
<211>  969
<212>  PRT
<213>  Homo Sapiens

<400>  6427

Met Trp Ala Met Glu Ser Gly His Leu Leu Trp Ala Leu Leu Phe Met 
1               5                   10                  15      


Gln Ser Leu Trp Pro Gln Leu Thr Asp Gly Ala Thr Arg Val Tyr Tyr 
            20                  25                  30          


Leu Gly Ile Arg Asp Val Gln Trp Asn Tyr Ala Pro Lys Gly Arg Asn 
        35                  40                  45              


Val Ile Thr Asn Gln Pro Leu Asp Ser Asp Ile Val Ala Ser Ser Phe 
    50                  55                  60                  


Leu Lys Ser Asp Lys Asn Arg Ile Gly Gly Thr Tyr Lys Lys Thr Ile 
65                  70                  75                  80  


Tyr Lys Glu Tyr Lys Asp Asp Ser Tyr Thr Asp Glu Val Ala Gln Pro 
                85                  90                  95      


Ala Trp Leu Gly Phe Leu Gly Pro Val Leu Gln Ala Glu Val Gly Asp 
            100                 105                 110         


Val Ile Leu Ile His Leu Lys Asn Phe Ala Thr Arg Pro Tyr Thr Ile 
        115                 120                 125             


His Pro His Gly Val Phe Tyr Glu Lys Asp Ser Glu Gly Ser Leu Tyr 
    130                 135                 140                 


Pro Asp Gly Ser Ser Gly Pro Leu Lys Ala Asp Asp Ser Val Pro Pro 
145                 150                 155                 160 


Gly Gly Ser His Ile Tyr Asn Trp Thr Ile Pro Glu Gly His Ala Pro 
                165                 170                 175     


Thr Asp Ala Asp Pro Ala Cys Leu Thr Trp Ile Tyr His Ser His Val 
            180                 185                 190         


Asp Ala Pro Arg Asp Ile Ala Thr Gly Leu Ile Gly Pro Leu Ile Thr 
        195                 200                 205             


Cys Lys Arg Gly Ala Leu Asp Gly Asn Ser Pro Pro Gln Arg Gln Asp 
    210                 215                 220                 


Val Asp His Asp Phe Phe Leu Leu Phe Ser Val Val Asp Glu Asn Leu 
225                 230                 235                 240 


Ser Trp His Leu Asn Glu Asn Ile Ala Thr Tyr Cys Ser Asp Pro Ala 
                245                 250                 255     


Ser Val Asp Lys Glu Asp Glu Thr Phe Gln Glu Ser Asn Arg Met His 
            260                 265                 270         


Ala Ile Asn Gly Phe Val Phe Gly Asn Leu Pro Glu Leu Asn Met Cys 
        275                 280                 285             


Ala Gln Lys Arg Val Ala Trp His Leu Phe Gly Met Gly Asn Glu Ile 
    290                 295                 300                 


Asp Val His Thr Ala Phe Phe His Gly Gln Met Leu Thr Thr Arg Gly 
305                 310                 315                 320 


His His Thr Asp Val Ala Asn Ile Phe Pro Ala Thr Phe Val Thr Ala 
                325                 330                 335     


Glu Met Val Pro Trp Glu Pro Gly Thr Trp Leu Ile Ser Cys Gln Val 
            340                 345                 350         


Asn Ser His Phe Arg Asp Gly Met Gln Ala Leu Tyr Lys Val Lys Ser 
        355                 360                 365             


Cys Ser Met Ala Pro Pro Val Asp Leu Leu Thr Gly Lys Val Arg Gln 
    370                 375                 380                 


Tyr Phe Ile Glu Ala His Glu Ile Gln Trp Asp Tyr Gly Pro Met Gly 
385                 390                 395                 400 


His Asp Gly Ser Thr Gly Lys Asn Leu Arg Glu Pro Gly Ser Ile Ser 
                405                 410                 415     


Asp Lys Phe Phe Gln Lys Ser Ser Ser Arg Ile Gly Gly Thr Tyr Trp 
            420                 425                 430         


Lys Val Arg Tyr Glu Ala Phe Gln Asp Glu Thr Phe Gln Glu Lys Met 
        435                 440                 445             


His Leu Glu Glu Asp Arg His Leu Gly Ile Leu Gly Pro Val Ile Arg 
    450                 455                 460                 


Ala Glu Val Gly Asp Thr Ile Gln Val Val Phe Tyr Asn Arg Ala Ser 
465                 470                 475                 480 


Gln Pro Phe Ser Met Gln Pro His Gly Val Phe Tyr Glu Lys Asp Tyr 
                485                 490                 495     


Glu Gly Thr Val Tyr Asn Asp Gly Thr Phe Glu Ile Tyr Cys Gln Ala 
            500                 505                 510         


Gly Ser His Arg Glu Ala Gly Met Arg Ala Ile Tyr Asn Val Ser Gln 
        515                 520                 525             


Cys Pro Gly His Gln Ala Thr Pro Arg Gln Arg Tyr Gln Ala Ala Arg 
    530                 535                 540                 


Ile Tyr Tyr Ile Met Ala Glu Glu Val Glu Trp Asp Tyr Cys Pro Asp 
545                 550                 555                 560 


Arg Ser Trp Glu Arg Glu Trp His Asn Gln Ser Glu Lys Asp Ser Tyr 
                565                 570                 575     


Gly Tyr Ile Phe Leu Ser Asn Lys Asp Gly Leu Leu Gly Ser Arg Tyr 
            580                 585                 590         


Lys Lys Ala Val Phe Arg Glu Tyr Thr Asp Gly Thr Phe Arg Ile Pro 
        595                 600                 605             


Arg Pro Arg Thr Gly Pro Glu Glu His Leu Gly Ile Leu Gly Pro Leu 
    610                 615                 620                 


Ile Lys Gly Glu Val Gly Asp Ile Leu Thr Val Val Phe Lys Asn Asn 
625                 630                 635                 640 


Ala Ser Arg Pro Tyr Ser Val His Ala His Gly Val Leu Glu Ser Thr 
                645                 650                 655     


Thr Val Trp Pro Leu Ala Ala Glu Pro Gly Glu Val Val Thr Tyr Gln 
            660                 665                 670         


Trp Asn Ile Pro Glu Arg Ser Gly Pro Gly Pro Asn Asp Ser Ala Cys 
        675                 680                 685             


Val Ser Trp Ile Tyr Tyr Ser Ala Val Asp Pro Ile Lys Asp Met Tyr 
    690                 695                 700                 


Ser Gly Leu Val Gly Pro Leu Ala Ile Cys Gln Lys Gly Ile Leu Glu 
705                 710                 715                 720 


Pro His Gly Gly Arg Ser Asp Met Asp Arg Glu Phe Ala Leu Leu Phe 
                725                 730                 735     


Leu Ile Phe Asp Glu Asn Lys Ser Trp Tyr Leu Glu Glu Asn Val Ala 
            740                 745                 750         


Thr His Gly Ser Gln Asp Pro Gly Ser Ile Asn Leu Gln Asp Glu Thr 
        755                 760                 765             


Phe Leu Glu Ser Asn Lys Met His Ala Ile Asn Gly Lys Leu Tyr Ala 
    770                 775                 780                 


Asn Leu Arg Gly Leu Thr Met Tyr Gln Gly Glu Arg Val Ala Trp Tyr 
785                 790                 795                 800 


Met Leu Ala Met Gly Gln Asp Val Asp Leu His Thr Ile His Phe His 
                805                 810                 815     


Ala Glu Ser Phe Leu Tyr Arg Asn Gly Glu Asn Tyr Arg Ala Asp Val 
            820                 825                 830         


Val Asp Leu Phe Pro Gly Thr Phe Glu Val Val Glu Met Val Ala Ser 
        835                 840                 845             


Asn Pro Gly Thr Trp Leu Met His Cys His Val Thr Asp His Val His 
    850                 855                 860                 


Ala Gly Met Glu Thr Leu Phe Thr Val Phe Ser Arg Thr Glu His Leu 
865                 870                 875                 880 


Ser Pro Leu Thr Val Ile Thr Lys Glu Thr Glu Lys Ala Val Pro Pro 
                885                 890                 895     


Arg Asp Ile Glu Glu Gly Asn Val Lys Met Leu Gly Met Gln Ile Pro 
            900                 905                 910         


Ile Lys Asn Val Glu Met Leu Ala Ser Val Leu Val Ala Ile Ser Val 
        915                 920                 925             


Thr Leu Leu Leu Val Val Leu Ala Leu Gly Gly Val Val Trp Tyr Gln 
    930                 935                 940                 


His Arg Gln Arg Lys Leu Arg Arg Asn Arg Arg Ser Ile Leu Asp Asp 
945                 950                 955                 960 


Ser Phe Lys Leu Leu Ser Phe Lys Gln 
                965                 


<210>  6428
<211>  63
<212>  PRT
<213>  Homo Sapiens

<400>  6428

Met Trp Ala Met Glu Ser Gly His Leu Leu Trp Ala Leu Leu Phe Met 
1               5                   10                  15      


Gln Ser Leu Trp Pro Gln Leu Thr Asp Gly Ala Thr Arg Val Tyr Tyr 
            20                  25                  30          


Leu Gly Ile Arg Asp Val Gln Trp Asn Tyr Ala Pro Lys Gly Arg Asn 
        35                  40                  45              


Val Ile Thr Asn Gln Pro Leu Asp Ser Asp Ile Tyr Val Lys Met 
    50                  55                  60              


<210>  6429
<211>  88
<212>  PRT
<213>  Homo Sapiens

<400>  6429

Met Thr Ser Ser Arg Leu Trp Phe Ser Leu Leu Leu Ala Ala Ala Phe 
1               5                   10                  15      


Ala Gly Arg Ala Thr Ala Leu Trp Pro Trp Pro Gln Asn Phe Gln Thr 
            20                  25                  30          


Ser Asp Gln Arg Tyr Val Leu Tyr Pro Asn Asn Phe Gln Phe Gln Tyr 
        35                  40                  45              


Asp Val Ser Ser Ala Ala Gln Pro Gly Cys Ser Val Leu Asp Glu Ala 
    50                  55                  60                  


Phe Gln Arg Tyr Arg Asp Leu Leu Phe Gly Ser Gly Ser Trp Pro Arg 
65                  70                  75                  80  


Pro Tyr Leu Thr Ala Asn Met Tyr 
                85              


<210>  6430
<211>  143
<212>  PRT
<213>  Homo Sapiens

<400>  6430

Met Thr Ser Ser Arg Leu Trp Phe Ser Leu Leu Leu Ala Ala Ala Phe 
1               5                   10                  15      


Ala Gly Arg Ala Thr Ala Leu Trp Pro Trp Pro Gln Asn Phe Gln Thr 
            20                  25                  30          


Ser Asp Gln Arg Tyr Val Leu Tyr Pro Asn Asn Phe Gln Phe Gln Tyr 
        35                  40                  45              


Asp Val Ser Ser Ala Ala Gln Pro Gly Cys Ser Val Leu Asp Glu Ala 
    50                  55                  60                  


Phe Gln Arg Tyr Arg Asp Leu Leu Phe Gly Ser Gly Ser Trp Pro Arg 
65                  70                  75                  80  


Pro Tyr Leu Thr Gly Lys Arg His Thr Leu Glu Lys Asn Val Leu Val 
                85                  90                  95      


Val Ser Val Val Thr Pro Gly Cys Asn Gln Leu Pro Thr Leu Glu Ser 
            100                 105                 110         


Val Glu Asn Tyr Thr Leu Thr Ile Asn Asp Asp Gln Cys Leu Leu Leu 
        115                 120                 125             


Ser Glu Thr Val Trp Gly Ala Leu Arg Gly Cys His Gly Val Gln 
    130                 135                 140             


<210>  6431
<211>  529
<212>  PRT
<213>  Homo Sapiens

<400>  6431

Met Thr Ser Ser Arg Leu Trp Phe Ser Leu Leu Leu Ala Ala Ala Phe 
1               5                   10                  15      


Ala Gly Arg Ala Thr Ala Leu Trp Pro Trp Pro Gln Asn Phe Gln Thr 
            20                  25                  30          


Ser Asp Gln Arg Tyr Val Leu Tyr Pro Asn Asn Phe Gln Phe Gln Tyr 
        35                  40                  45              


Asp Val Ser Ser Ala Ala Gln Pro Gly Cys Ser Val Leu Asp Glu Ala 
    50                  55                  60                  


Phe Gln Arg Tyr Arg Asp Leu Leu Phe Gly Ser Gly Ser Trp Pro Arg 
65                  70                  75                  80  


Pro Tyr Leu Thr Gly Lys Arg His Thr Leu Glu Lys Asn Val Leu Val 
                85                  90                  95      


Val Ser Val Val Thr Pro Gly Cys Asn Gln Leu Pro Thr Leu Glu Ser 
            100                 105                 110         


Val Glu Asn Tyr Thr Leu Thr Ile Asn Asp Asp Gln Cys Leu Leu Leu 
        115                 120                 125             


Ser Glu Thr Val Trp Gly Ala Leu Arg Gly Leu Glu Thr Phe Ser Gln 
    130                 135                 140                 


Leu Val Trp Lys Ser Ala Glu Gly Thr Phe Phe Ile Asn Lys Thr Glu 
145                 150                 155                 160 


Ile Glu Asp Phe Pro Arg Phe Pro His Arg Gly Leu Leu Leu Asp Thr 
                165                 170                 175     


Ser Arg His Tyr Leu Pro Leu Ser Ser Ile Leu Asp Thr Leu Asp Val 
            180                 185                 190         


Met Ala Tyr Asn Lys Leu Asn Val Phe His Trp His Leu Val Asp Asp 
        195                 200                 205             


Pro Ser Phe Pro Tyr Glu Ser Phe Thr Phe Pro Glu Leu Met Arg Lys 
    210                 215                 220                 


Gly Ser Tyr Asn Pro Val Thr His Ile Tyr Thr Ala Gln Asp Val Lys 
225                 230                 235                 240 


Glu Val Ile Glu Tyr Ala Arg Leu Arg Gly Ile Arg Val Leu Ala Glu 
                245                 250                 255     


Phe Asp Thr Pro Gly His Thr Leu Ser Trp Gly Pro Gly Ile Pro Gly 
            260                 265                 270         


Leu Leu Thr Pro Cys Tyr Ser Gly Ser Glu Pro Ser Gly Thr Phe Gly 
        275                 280                 285             


Pro Val Asn Pro Ser Leu Asn Asn Thr Tyr Glu Phe Met Ser Thr Phe 
    290                 295                 300                 


Phe Leu Glu Val Ser Ser Val Phe Pro Asp Phe Tyr Leu His Leu Gly 
305                 310                 315                 320 


Gly Asp Glu Val Asp Phe Thr Cys Trp Lys Ser Asn Pro Glu Ile Gln 
                325                 330                 335     


Asp Phe Met Arg Lys Lys Gly Phe Gly Glu Asp Phe Lys Gln Leu Glu 
            340                 345                 350         


Ser Phe Tyr Ile Gln Thr Leu Leu Asp Ile Val Ser Ser Tyr Gly Lys 
        355                 360                 365             


Gly Tyr Val Val Trp Gln Glu Val Phe Asp Asn Lys Val Lys Ile Gln 
    370                 375                 380                 


Pro Asp Thr Ile Ile Gln Val Trp Arg Glu Asp Ile Pro Val Asn Tyr 
385                 390                 395                 400 


Met Lys Glu Leu Glu Leu Val Thr Lys Ala Gly Phe Arg Ala Leu Leu 
                405                 410                 415     


Ser Ala Pro Trp Tyr Leu Asn Arg Ile Ser Tyr Gly Pro Asp Trp Lys 
            420                 425                 430         


Asp Phe Tyr Ile Val Glu Pro Leu Ala Phe Glu Gly Thr Pro Glu Gln 
        435                 440                 445             


Lys Ala Leu Val Ile Gly Gly Glu Ala Cys Met Trp Gly Glu Tyr Val 
    450                 455                 460                 


Asp Asn Thr Asn Leu Val Pro Arg Leu Trp Pro Arg Ala Gly Ala Val 
465                 470                 475                 480 


Ala Glu Arg Leu Trp Ser Asn Lys Leu Thr Ser Asp Leu Thr Phe Ala 
                485                 490                 495     


Tyr Glu Arg Leu Ser His Phe Arg Cys Glu Leu Leu Arg Arg Gly Val 
            500                 505                 510         


Gln Ala Gln Pro Leu Asn Val Gly Phe Cys Glu Gln Glu Phe Glu Gln 
        515                 520                 525             


Thr 
    


<210>  6432
<211>  509
<212>  PRT
<213>  Homo Sapiens

<400>  6432

Met Thr Ser Ser Arg Leu Trp Phe Ser Leu Leu Leu Ala Ala Ala Phe 
1               5                   10                  15      


Ala Gly Arg Ala Thr Ala Leu Trp Pro Trp Pro Gln Asn Phe Gln Thr 
            20                  25                  30          


Ser Asp Gln Arg Tyr Val Leu Tyr Pro Asn Asn Phe Gln Phe Gln Tyr 
        35                  40                  45              


Asp Val Ser Ser Ala Ala Gln Pro Gly Cys Ser Val Leu Asp Glu Ala 
    50                  55                  60                  


Phe Gln Arg Tyr Arg Asp Leu Leu Phe Gly Ser Gly Ser Trp Pro Arg 
65                  70                  75                  80  


Pro Tyr Leu Thr Gly Lys Arg His Thr Leu Glu Lys Asn Val Leu Val 
                85                  90                  95      


Val Ser Val Val Thr Pro Gly Cys Asn Gln Leu Pro Thr Leu Glu Ser 
            100                 105                 110         


Val Glu Asn Tyr Thr Leu Thr Ile Asn Asp Asp Gln Cys Leu Leu Leu 
        115                 120                 125             


Ser Glu Thr Val Trp Gly Ala Leu Arg Gly Leu Glu Thr Phe Ser Gln 
    130                 135                 140                 


Leu Val Trp Lys Ser Ala Glu Gly Thr Phe Phe Ile Asn Lys Thr Glu 
145                 150                 155                 160 


Ile Glu Asp Phe Pro Arg Phe Pro His Arg Gly Leu Leu Leu Asp Thr 
                165                 170                 175     


Ser Arg His Tyr Leu Pro Leu Ser Ser Ile Leu Asp Thr Leu Asp Val 
            180                 185                 190         


Met Ala Tyr Asn Lys Leu Asn Val Phe His Trp His Leu Val Asp Asp 
        195                 200                 205             


Pro Ser Phe Pro Tyr Glu Ser Phe Thr Phe Pro Glu Leu Met Arg Lys 
    210                 215                 220                 


Gly Ser Tyr Asn Pro Val Thr His Ile Tyr Thr Ala Gln Asp Val Lys 
225                 230                 235                 240 


Glu Val Ile Glu Tyr Ala Arg Leu Arg Gly Ile Arg Val Leu Ala Glu 
                245                 250                 255     


Phe Asp Thr Pro Gly His Thr Leu Ser Trp Gly Pro Gly Ile Pro Gly 
            260                 265                 270         


Leu Leu Thr Pro Cys Tyr Ser Gly Ser Glu Pro Ser Gly Thr Phe Gly 
        275                 280                 285             


Pro Val Asn Pro Ser Leu Asn Asn Thr Tyr Glu Phe Met Ser Thr Phe 
    290                 295                 300                 


Phe Leu Glu Val Ser Ser Val Phe Pro Asp Phe Tyr Leu His Leu Gly 
305                 310                 315                 320 


Gly Asp Glu Val Asp Phe Thr Cys Trp Lys Ser Asn Pro Glu Ile Gln 
                325                 330                 335     


Asp Phe Met Arg Lys Lys Gly Phe Gly Glu Asp Phe Lys Gln Leu Glu 
            340                 345                 350         


Ser Phe Tyr Ile Gln Thr Leu Leu Asp Ile Val Ser Ser Tyr Gly Lys 
        355                 360                 365             


Gly Tyr Val Val Trp Gln Glu Val Phe Asp Asn Lys Val Lys Ile Gln 
    370                 375                 380                 


Pro Asp Thr Ile Ile Gln Val Trp Arg Glu Asp Ile Pro Val Asn Tyr 
385                 390                 395                 400 


Met Lys Glu Leu Glu Leu Val Thr Lys Ala Gly Phe Arg Ala Leu Leu 
                405                 410                 415     


Ser Ala Pro Trp Tyr Leu Asn Arg Ile Ser Tyr Gly Pro Asp Trp Lys 
            420                 425                 430         


Asp Phe Tyr Ile Val Glu Pro Leu Ala Phe Glu Gly Thr Pro Glu Gln 
        435                 440                 445             


Lys Ala Leu Val Ile Gly Gly Glu Ala Cys Met Trp Gly Glu Tyr Val 
    450                 455                 460                 


Asp Asn Thr Asn Leu Val Pro Arg Leu Trp Pro Arg Ala Gly Ala Val 
465                 470                 475                 480 


Ala Glu Arg Leu Trp Ser Asn Lys Leu Thr Ser Asp Leu Thr Phe Ala 
                485                 490                 495     


Tyr Glu Arg Leu Ser His Phe Arg Cys Glu Leu Leu Arg 
            500                 505                 


<210>  6433
<211>  373
<212>  PRT
<213>  Homo Sapiens

<400>  6433

Met Thr Ser Ser Arg Leu Trp Phe Ser Leu Leu Leu Ala Ala Ala Phe 
1               5                   10                  15      


Ala Gly Arg Ala Thr Ala Leu Trp Pro Trp Pro Gln Asn Phe Gln Thr 
            20                  25                  30          


Ser Asp Gln Arg Tyr Val Leu Tyr Pro Asn Asn Phe Gln Phe Gln Tyr 
        35                  40                  45              


Asp Val Ser Ser Ala Ala Gln Pro Gly Cys Ser Val Leu Asp Glu Ala 
    50                  55                  60                  


Phe Gln Arg Tyr Arg Asp Leu Leu Phe Gly Ser Gly Ser Trp Pro Arg 
65                  70                  75                  80  


Pro Tyr Leu Thr Gly Lys Arg His Thr Leu Glu Lys Asn Val Leu Val 
                85                  90                  95      


Val Ser Val Val Thr Pro Gly Cys Asn Gln Leu Pro Thr Leu Glu Ser 
            100                 105                 110         


Val Glu Asn Tyr Thr Leu Thr Ile Asn Asp Asp Gln Cys Leu Leu Leu 
        115                 120                 125             


Ser Glu Thr Val Trp Gly Ala Leu Arg Gly Leu Glu Thr Phe Ser Gln 
    130                 135                 140                 


Leu Val Trp Lys Ser Ala Glu Gly Thr Phe Phe Ile Asn Lys Thr Glu 
145                 150                 155                 160 


Ile Glu Asp Phe Pro Arg Phe Pro His Arg Gly Leu Leu Leu Asp Thr 
                165                 170                 175     


Ser Arg His Tyr Leu Pro Leu Ser Ser Ile Leu Asp Thr Leu Asp Val 
            180                 185                 190         


Met Ala Tyr Asn Lys Leu Asn Val Phe His Trp His Leu Val Asp Asp 
        195                 200                 205             


Pro Ser Phe Pro Tyr Glu Ser Phe Thr Phe Pro Glu Leu Met Arg Lys 
    210                 215                 220                 


Gly Ser Tyr Asn Pro Val Thr His Ile Tyr Thr Ala Gln Asp Val Lys 
225                 230                 235                 240 


Glu Val Ile Glu Tyr Ala Arg Leu Arg Gly Ile Arg Val Leu Ala Glu 
                245                 250                 255     


Phe Asp Thr Pro Gly His Thr Leu Ser Trp Gly Pro Gly Ile Pro Gly 
            260                 265                 270         


Leu Leu Thr Pro Cys Tyr Ser Gly Ser Glu Pro Ser Gly Thr Phe Gly 
        275                 280                 285             


Pro Val Asn Pro Ser Leu Asn Asn Thr Tyr Glu Phe Met Ser Thr Phe 
    290                 295                 300                 


Phe Leu Glu Val Ser Ser Val Phe Pro Asp Phe Tyr Leu His Leu Gly 
305                 310                 315                 320 


Gly Asp Glu Val Asp Phe Thr Cys Trp Lys Ser Asn Pro Glu Ile Gln 
                325                 330                 335     


Asp Phe Met Arg Lys Lys Gly Phe Gly Glu Asp Phe Lys Gln Leu Glu 
            340                 345                 350         


Ser Phe Tyr Ile Gln Thr Phe Ser Gln Thr Gln Ser Tyr Arg Cys Gly 
        355                 360                 365             


Glu Arg Ile Phe Gln 
    370             


<210>  6434
<211>  143
<212>  PRT
<213>  Homo Sapiens

<400>  6434

Met Thr Ser Ser Arg Leu Trp Phe Ser Leu Leu Leu Ala Ala Ala Phe 
1               5                   10                  15      


Ala Gly Arg Ala Thr Ala Leu Trp Pro Trp Pro Gln Asn Phe Gln Thr 
            20                  25                  30          


Ser Asp Gln Arg Tyr Val Leu Tyr Pro Asn Asn Phe Gln Phe Gln Tyr 
        35                  40                  45              


Asp Val Ser Ser Ala Ala Gln Pro Gly Cys Ser Val Leu Asp Glu Ala 
    50                  55                  60                  


Phe Gln Arg Tyr Arg Asp Leu Leu Phe Gly Ser Gly Ser Trp Pro Arg 
65                  70                  75                  80  


Pro Tyr Leu Thr Gly Lys Arg His Thr Leu Glu Lys Asn Val Leu Val 
                85                  90                  95      


Val Ser Val Val Thr Pro Gly Cys Asn Gln Leu Pro Thr Leu Glu Ser 
            100                 105                 110         


Val Glu Asn Tyr Thr Leu Thr Ile Asn Asp Asp Gln Cys Leu Leu Leu 
        115                 120                 125             


Ser Glu Thr Val Trp Gly Ala Leu Arg Val Leu Tyr Gln Gln Asp 
    130                 135                 140             


<210>  6435
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  6435

Met Thr Ser Ser Arg Leu Trp Phe Ser Leu Leu Leu Ala Ala Ala Phe 
1               5                   10                  15      


Ala Gly Arg Ala Thr Ala Leu Trp Pro Trp Pro Gln Asn Phe Gln Thr 
            20                  25                  30          


Ser Asp Gln Arg Tyr Val Leu Tyr Pro Asn Asn Phe Gln Phe Gln Tyr 
        35                  40                  45              


Asp Val Ser Ser Ala Ala Gln Pro Gly Cys Ser Val Leu Asp Glu Ala 
    50                  55                  60                  


Phe Gln Arg Tyr Arg Asp Leu Leu Phe Gly Ser Gly Ser Trp Pro Arg 
65                  70                  75                  80  


Pro Tyr Leu Thr Gly Leu Ser Leu Ser Phe Arg Leu Glu Cys Ser Gly 
                85                  90                  95      


Val Ile Thr Ala Tyr Ser Asn Leu Glu Leu Gln Asp Ser Ser Ser Leu 
            100                 105                 110         


Pro Ala Ser Leu Met Ser Ser 
        115                 


<210>  6436
<211>  540
<212>  PRT
<213>  Homo Sapiens

<400>  6436

Met Thr Ser Ser Arg Leu Trp Phe Ser Leu Leu Leu Ala Ala Ala Phe 
1               5                   10                  15      


Ala Gly Arg Ala Thr Ala Leu Trp Pro Trp Pro Gln Asn Phe Gln Thr 
            20                  25                  30          


Ser Asp Gln Arg Tyr Val Leu Tyr Pro Asn Asn Phe Gln Phe Gln Tyr 
        35                  40                  45              


Asp Val Ser Ser Ala Ala Gln Pro Gly Cys Ser Val Leu Asp Glu Ala 
    50                  55                  60                  


Phe Gln Arg Tyr Arg Asp Leu Leu Phe Gly Ser Gly Ser Trp Pro Arg 
65                  70                  75                  80  


Pro Tyr Leu Thr Gly Trp Pro His Gln Ala Tyr Pro Val Phe Leu Gly 
                85                  90                  95      


Lys Arg His Thr Leu Glu Lys Asn Val Leu Val Val Ser Val Val Thr 
            100                 105                 110         


Pro Gly Cys Asn Gln Leu Pro Thr Leu Glu Ser Val Glu Asn Tyr Thr 
        115                 120                 125             


Leu Thr Ile Asn Asp Asp Gln Cys Leu Leu Leu Ser Glu Thr Val Trp 
    130                 135                 140                 


Gly Ala Leu Arg Gly Leu Glu Thr Phe Ser Gln Leu Val Trp Lys Ser 
145                 150                 155                 160 


Ala Glu Gly Thr Phe Phe Ile Asn Lys Thr Glu Ile Glu Asp Phe Pro 
                165                 170                 175     


Arg Phe Pro His Arg Gly Leu Leu Leu Asp Thr Ser Arg His Tyr Leu 
            180                 185                 190         


Pro Leu Ser Ser Ile Leu Asp Thr Leu Asp Val Met Ala Tyr Asn Lys 
        195                 200                 205             


Leu Asn Val Phe His Trp His Leu Val Asp Asp Pro Ser Phe Pro Tyr 
    210                 215                 220                 


Glu Ser Phe Thr Phe Pro Glu Leu Met Arg Lys Gly Ser Tyr Asn Pro 
225                 230                 235                 240 


Val Thr His Ile Tyr Thr Ala Gln Asp Val Lys Glu Val Ile Glu Tyr 
                245                 250                 255     


Ala Arg Leu Arg Gly Ile Arg Val Leu Ala Glu Phe Asp Thr Pro Gly 
            260                 265                 270         


His Thr Leu Ser Trp Gly Pro Gly Ile Pro Gly Leu Leu Thr Pro Cys 
        275                 280                 285             


Tyr Ser Gly Ser Glu Pro Ser Gly Thr Phe Gly Pro Val Asn Pro Ser 
    290                 295                 300                 


Leu Asn Asn Thr Tyr Glu Phe Met Ser Thr Phe Phe Leu Glu Val Ser 
305                 310                 315                 320 


Ser Val Phe Pro Asp Phe Tyr Leu His Leu Gly Gly Asp Glu Val Asp 
                325                 330                 335     


Phe Thr Cys Trp Lys Ser Asn Pro Glu Ile Gln Asp Phe Met Arg Lys 
            340                 345                 350         


Lys Gly Phe Gly Glu Asp Phe Lys Gln Leu Glu Ser Phe Tyr Ile Gln 
        355                 360                 365             


Thr Leu Leu Asp Ile Val Ser Ser Tyr Gly Lys Gly Tyr Val Val Trp 
    370                 375                 380                 


Gln Glu Val Phe Asp Asn Lys Val Lys Ile Gln Pro Asp Thr Ile Ile 
385                 390                 395                 400 


Gln Val Trp Arg Glu Asp Ile Pro Val Asn Tyr Met Lys Glu Leu Glu 
                405                 410                 415     


Leu Val Thr Lys Ala Gly Phe Arg Ala Leu Leu Ser Ala Pro Trp Tyr 
            420                 425                 430         


Leu Asn Arg Ile Ser Tyr Gly Pro Asp Trp Lys Asp Phe Tyr Ile Val 
        435                 440                 445             


Glu Pro Leu Ala Phe Glu Gly Thr Pro Glu Gln Lys Ala Leu Val Ile 
    450                 455                 460                 


Gly Gly Glu Ala Cys Met Trp Gly Glu Tyr Val Asp Asn Thr Asn Leu 
465                 470                 475                 480 


Val Pro Arg Leu Trp Pro Arg Ala Gly Ala Val Ala Glu Arg Leu Trp 
                485                 490                 495     


Ser Asn Lys Leu Thr Ser Asp Leu Thr Phe Ala Tyr Glu Arg Leu Ser 
            500                 505                 510         


His Phe Arg Cys Glu Leu Leu Arg Arg Gly Val Gln Ala Gln Pro Leu 
        515                 520                 525             


Asn Val Gly Phe Cys Glu Gln Glu Phe Glu Gln Thr 
    530                 535                 540 


<210>  6437
<211>  318
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6437

Xaa Phe Gln Phe Gln Tyr Asp Val Ser Ser Ala Ala Gln Pro Gly Cys 
1               5                   10                  15      


Ser Val Leu Asp Glu Ala Phe Gln Arg Tyr Arg Asp Leu Leu Phe Gly 
            20                  25                  30          


Ser Gly Ser Trp Pro Arg Pro Tyr Leu Thr Gly Lys Arg His Thr Leu 
        35                  40                  45              


Glu Lys Asn Val Leu Val Val Ser Val Val Thr Pro Gly Cys Asn Gln 
    50                  55                  60                  


Leu Pro Thr Leu Glu Ser Val Glu Asn Tyr Thr Leu Thr Ile Asn Asp 
65                  70                  75                  80  


Asp Gln Cys Leu Leu Leu Ser Glu Thr Val Trp Gly Ala Leu Arg Gly 
                85                  90                  95      


Leu Glu Thr Phe Ser Gln Leu Val Trp Lys Ser Ala Glu Gly Thr Phe 
            100                 105                 110         


Phe Ile Asn Lys Thr Glu Ile Glu Asp Phe Pro Arg Phe Pro His Arg 
        115                 120                 125             


Gly Leu Leu Leu Asp Thr Ser Arg His Tyr Leu Pro Leu Ser Ser Ile 
    130                 135                 140                 


Leu Asp Thr Leu Asp Val Met Ala Tyr Asn Lys Leu Asn Val Phe His 
145                 150                 155                 160 


Trp His Leu Val Asp Asp Pro Ser Phe Pro Tyr Glu Ser Phe Thr Phe 
                165                 170                 175     


Pro Glu Leu Met Arg Lys Gly Ser Tyr Asn Pro Val Thr His Ile Tyr 
            180                 185                 190         


Thr Ala Gln Asp Val Lys Glu Val Ile Glu Tyr Ala Arg Leu Arg Gly 
        195                 200                 205             


Ile Arg Val Leu Ala Glu Phe Asp Thr Pro Gly His Thr Leu Ser Trp 
    210                 215                 220                 


Gly Pro Gly Ile Pro Gly Leu Leu Thr Pro Cys Tyr Ser Gly Ser Glu 
225                 230                 235                 240 


Pro Ser Gly Thr Phe Gly Pro Val Asn Pro Ser Leu Asn Asn Thr Tyr 
                245                 250                 255     


Glu Phe Met Ser Thr Phe Phe Leu Glu Val Ser Ser Val Phe Pro Asp 
            260                 265                 270         


Phe Tyr Leu His Leu Gly Gly Asp Glu Val Asp Phe Thr Cys Trp Lys 
        275                 280                 285             


Ser Asn Pro Glu Ile Gln Asp Phe Met Arg Lys Lys Gly Phe Gly Glu 
    290                 295                 300                 


Asp Phe Lys Gln Leu Glu Ser Phe Tyr Ile Gln Thr Tyr Pro 
305                 310                 315             


<210>  6438
<211>  128
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6438

Xaa Phe Ser Leu Leu Leu Ala Ala Ala Phe Ala Gly Arg Ala Thr Ala 
1               5                   10                  15      


Leu Trp Pro Trp Pro Gln Asn Phe Gln Thr Ser Asp Gln Arg Tyr Val 
            20                  25                  30          


Leu Tyr Pro Asn Asn Phe Gln Phe Gln Tyr Asp Val Ser Ser Ala Ala 
        35                  40                  45              


Gln Pro Gly Cys Ser Val Leu Asp Glu Ala Phe Gln Arg Tyr Arg Asp 
    50                  55                  60                  


Leu Leu Phe Gly Ser Gly Ser Trp Pro Arg Pro Tyr Leu Thr Gly Lys 
65                  70                  75                  80  


Arg His Thr Leu Glu Lys Asn Val Leu Val Val Ser Val Val Thr Pro 
                85                  90                  95      


Gly Cys Asn Gln Leu Pro Thr Leu Glu Ser Val Glu Asn Cys Ile Pro 
            100                 105                 110         


Val Pro Phe Ala Arg Arg Arg Leu Leu Ser Ser Phe Cys Cys Gly Asn 
        115                 120                 125             


<210>  6439
<211>  331
<212>  PRT
<213>  Homo Sapiens

<400>  6439

Met Ala Phe Asn Lys Phe Asn Val Leu His Trp His Ile Val Asp Asp 
1               5                   10                  15      


Gln Ser Phe Pro Tyr Gln Ser Ile Thr Phe Pro Glu Leu Ser Asn Lys 
            20                  25                  30          


Gly Ser Tyr Ser Leu Ser His Val Tyr Thr Pro Asn Asp Val Arg Met 
        35                  40                  45              


Val Ile Glu Tyr Ala Arg Leu Arg Gly Ile Arg Val Leu Pro Glu Phe 
    50                  55                  60                  


Asp Thr Pro Gly His Thr Leu Ser Trp Gly Lys Gly Gln Lys Asp Leu 
65                  70                  75                  80  


Leu Thr Pro Cys Tyr Ser Arg Gln Asn Lys Leu Asp Ser Phe Gly Pro 
                85                  90                  95      


Ile Asn Pro Thr Leu Asn Thr Thr Tyr Ser Phe Leu Thr Thr Phe Phe 
            100                 105                 110         


Lys Glu Ile Ser Glu Val Phe Pro Asp Gln Phe Ile His Leu Gly Gly 
        115                 120                 125             


Asp Glu Val Glu Phe Lys Cys Trp Glu Ser Asn Pro Lys Ile Gln Asp 
    130                 135                 140                 


Phe Met Arg Gln Lys Gly Phe Gly Thr Asp Phe Lys Lys Leu Glu Ser 
145                 150                 155                 160 


Phe Tyr Ile Gln Lys Val Leu Asp Ile Ile Ala Thr Ile Asn Lys Gly 
                165                 170                 175     


Ser Ile Val Trp Gln Glu Val Phe Asp Asp Lys Ala Lys Leu Ala Pro 
            180                 185                 190         


Gly Thr Ile Val Glu Val Trp Lys Asp Ser Ala Tyr Pro Glu Glu Leu 
        195                 200                 205             


Ser Arg Val Thr Ala Ser Gly Phe Pro Val Ile Leu Ser Ala Pro Trp 
    210                 215                 220                 


Tyr Leu Asp Leu Ile Ser Tyr Gly Gln Asp Trp Arg Lys Tyr Tyr Lys 
225                 230                 235                 240 


Val Glu Pro Leu Asp Phe Gly Gly Thr Gln Lys Gln Lys Gln Leu Phe 
                245                 250                 255     


Ile Gly Gly Glu Ala Cys Leu Trp Gly Glu Tyr Val Asp Ala Thr Asn 
            260                 265                 270         


Leu Thr Pro Arg Leu Trp Pro Arg Ala Ser Ala Val Gly Glu Arg Leu 
        275                 280                 285             


Trp Ser Ser Lys Asp Val Arg Asp Met Asp Asp Ala Tyr Asp Arg Leu 
    290                 295                 300                 


Thr Arg His Arg Cys Arg Met Val Glu Arg Gly Ile Ala Ala Gln Pro 
305                 310                 315                 320 


Leu Tyr Ala Gly Tyr Cys Asn His Glu Asn Met 
                325                 330     


<210>  6440
<211>  35
<212>  PRT
<213>  Homo Sapiens

<400>  6440

Met Asp Asp Ala Tyr Asp Arg Leu Thr Arg His Arg Cys Arg Met Val 
1               5                   10                  15      


Glu Arg Gly Ile Ala Ala Gln Pro Leu Tyr Ala Gly Tyr Cys Asn His 
            20                  25                  30          


Glu Asn Met 
        35  


<210>  6441
<211>  556
<212>  PRT
<213>  Homo Sapiens

<400>  6441

Met Glu Leu Cys Gly Leu Gly Leu Pro Arg Pro Pro Met Leu Leu Ala 
1               5                   10                  15      


Leu Leu Leu Ala Thr Leu Leu Ala Ala Met Leu Ala Leu Leu Thr Gln 
            20                  25                  30          


Val Ala Leu Val Val Gln Val Ala Glu Ala Ala Arg Ala Pro Ser Val 
        35                  40                  45              


Ser Ala Lys Pro Gly Pro Ala Leu Trp Pro Leu Pro Leu Leu Val Lys 
    50                  55                  60                  


Met Thr Pro Asn Leu Leu His Leu Ala Pro Glu Asn Phe Tyr Ile Ser 
65                  70                  75                  80  


His Ser Pro Asn Ser Thr Ala Gly Pro Ser Cys Thr Leu Leu Glu Glu 
                85                  90                  95      


Ala Phe Arg Arg Tyr His Gly Tyr Ile Phe Gly Phe Tyr Lys Trp His 
            100                 105                 110         


His Glu Pro Ala Glu Phe Gln Ala Lys Thr Gln Val Gln Gln Leu Leu 
        115                 120                 125             


Val Ser Ile Thr Leu Gln Ser Glu Cys Asp Ala Phe Pro Asn Ile Ser 
    130                 135                 140                 


Ser Asp Glu Ser Tyr Thr Leu Leu Val Lys Glu Pro Val Ala Val Leu 
145                 150                 155                 160 


Lys Ala Asn Arg Val Trp Gly Ala Leu Arg Gly Leu Glu Thr Phe Ser 
                165                 170                 175     


Gln Leu Val Tyr Gln Asp Ser Tyr Gly Thr Phe Thr Ile Asn Glu Ser 
            180                 185                 190         


Thr Ile Ile Asp Ser Pro Arg Phe Ser His Arg Gly Ile Leu Ile Asp 
        195                 200                 205             


Thr Ser Arg His Tyr Leu Pro Val Lys Ile Ile Leu Lys Thr Leu Asp 
    210                 215                 220                 


Ala Met Ala Phe Asn Lys Phe Asn Val Leu His Trp His Ile Val Asp 
225                 230                 235                 240 


Asp Gln Ser Phe Pro Tyr Gln Ser Ile Thr Phe Pro Glu Leu Ser Asn 
                245                 250                 255     


Lys Gly Ser Tyr Ser Leu Ser His Val Tyr Thr Pro Asn Asp Val Arg 
            260                 265                 270         


Met Val Ile Glu Tyr Ala Arg Leu Arg Gly Ile Arg Val Leu Pro Glu 
        275                 280                 285             


Phe Asp Thr Pro Gly His Thr Leu Ser Trp Gly Lys Gly Gln Lys Asp 
    290                 295                 300                 


Leu Leu Thr Pro Cys Tyr Ser Arg Gln Asn Lys Leu Asp Ser Phe Gly 
305                 310                 315                 320 


Pro Ile Asn Pro Thr Leu Asn Thr Thr Tyr Ser Phe Leu Thr Thr Phe 
                325                 330                 335     


Phe Lys Glu Ile Ser Glu Val Phe Pro Asp Gln Phe Ile His Leu Gly 
            340                 345                 350         


Gly Asp Glu Val Glu Phe Lys Cys Trp Glu Ser Asn Pro Lys Ile Gln 
        355                 360                 365             


Asp Phe Met Arg Gln Lys Gly Phe Gly Thr Asp Phe Lys Lys Leu Glu 
    370                 375                 380                 


Ser Phe Tyr Ile Gln Lys Val Leu Asp Ile Ile Ala Thr Ile Asn Lys 
385                 390                 395                 400 


Gly Ser Ile Val Trp Gln Glu Val Phe Asp Asp Lys Ala Lys Leu Ala 
                405                 410                 415     


Pro Gly Thr Ile Val Glu Val Trp Lys Asp Ser Ala Tyr Pro Glu Glu 
            420                 425                 430         


Leu Ser Arg Val Thr Ala Ser Gly Phe Pro Val Ile Leu Ser Ala Pro 
        435                 440                 445             


Trp Tyr Leu Asp Leu Ile Ser Tyr Gly Gln Asp Trp Arg Lys Tyr Tyr 
    450                 455                 460                 


Lys Val Glu Pro Leu Asp Phe Gly Gly Thr Gln Lys Gln Lys Gln Leu 
465                 470                 475                 480 


Phe Ile Gly Gly Glu Ala Cys Leu Trp Gly Glu Tyr Val Asp Ala Thr 
                485                 490                 495     


Asn Leu Thr Pro Arg Leu Trp Pro Arg Ala Ser Ala Val Gly Glu Arg 
            500                 505                 510         


Leu Trp Ser Ser Lys Asp Val Arg Asp Met Asp Asp Ala Tyr Asp Arg 
        515                 520                 525             


Leu Thr Arg His Arg Cys Arg Met Val Glu Arg Gly Ile Ala Ala Gln 
    530                 535                 540                 


Pro Leu Tyr Ala Gly Tyr Cys Asn His Glu Asn Met 
545                 550                 555     


<210>  6442
<211>  52
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6442

Xaa Asp Ala Thr Asn Leu Thr Pro Arg Leu Trp Pro Arg Ala Ser Ala 
1               5                   10                  15      


Val Gly Glu Arg Leu Trp Ser Ser Lys Asp Val Arg Asp Met Asp Asp 
            20                  25                  30          


Ala Tyr Asp Arg Leu Thr Arg His Arg Cys Arg Met Val Glu Gly Leu 
        35                  40                  45              


Ala Ser Phe Leu 
    50          


<210>  6443
<211>  170
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6443

Xaa Phe Gly Thr Asp Phe Lys Lys Leu Glu Ser Phe Tyr Ile Gln Lys 
1               5                   10                  15      


Val Leu Asp Ile Ile Ala Thr Ile Asn Lys Gly Ser Ile Val Trp Gln 
            20                  25                  30          


Glu Val Phe Asp Asp Lys Ala Lys Leu Ala Pro Gly Thr Ile Val Glu 
        35                  40                  45              


Val Trp Lys Asp Ser Ala Tyr Pro Glu Glu Leu Ser Arg Val Thr Ala 
    50                  55                  60                  


Ser Gly Phe Pro Val Ile Leu Ser Ala Pro Trp Tyr Leu Asp Leu Ile 
65                  70                  75                  80  


Ser Tyr Gly Gln Asp Trp Arg Lys Tyr Tyr Lys Val Glu Pro Leu Asp 
                85                  90                  95      


Phe Gly Gly Thr Gln Lys Gln Lys Gln Leu Phe Ile Gly Gly Glu Ala 
            100                 105                 110         


Cys Leu Trp Gly Glu Tyr Val Asp Ala Thr Asn Leu Thr Pro Arg Leu 
        115                 120                 125             


Trp Pro Arg Ala Ser Ala Val Gly Glu Arg Leu Trp Ser Ser Lys Asp 
    130                 135                 140                 


Val Arg Asp Met Asp Asp Ala Tyr Asp Arg Leu Thr Arg His Arg Cys 
145                 150                 155                 160 


Arg Met Val Glu Gly Leu Ala Ser Phe Leu 
                165                 170 


<210>  6444
<211>  202
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6444

Xaa Asn Thr Thr Tyr Ser Phe Leu Thr Thr Phe Phe Lys Glu Ile Ser 
1               5                   10                  15      


Glu Val Phe Pro Asp Gln Phe Ile His Leu Gly Gly Asp Glu Val Glu 
            20                  25                  30          


Phe Lys Cys Trp Val Leu Asp Ile Ile Ala Thr Ile Asn Lys Gly Ser 
        35                  40                  45              


Ile Val Trp Gln Glu Val Phe Asp Asp Lys Ala Lys Leu Ala Pro Gly 
    50                  55                  60                  


Thr Ile Val Glu Val Trp Lys Asp Ser Ala Tyr Pro Glu Glu Leu Ser 
65                  70                  75                  80  


Arg Val Thr Ala Ser Gly Phe Pro Val Ile Leu Ser Ala Pro Trp Tyr 
                85                  90                  95      


Leu Asp Leu Ile Ser Tyr Gly Gln Asp Trp Arg Lys Tyr Tyr Lys Val 
            100                 105                 110         


Glu Pro Leu Asp Phe Gly Gly Thr Gln Lys Gln Lys Gln Leu Phe Ile 
        115                 120                 125             


Gly Gly Glu Ala Cys Leu Trp Gly Glu Tyr Val Asp Ala Thr Asn Leu 
    130                 135                 140                 


Thr Pro Arg Leu Trp Pro Arg Ala Ser Ala Val Gly Glu Arg Leu Trp 
145                 150                 155                 160 


Ser Ser Lys Asp Val Arg Asp Met Asp Asp Ala Tyr Asp Arg Leu Thr 
                165                 170                 175     


Arg His Arg Cys Arg Met Val Glu Arg Gly Ile Ala Ala Gln Pro Leu 
            180                 185                 190         


Tyr Ala Gly Tyr Cys Asn His Glu Asn Met 
        195                 200         


<210>  6445
<211>  70
<212>  PRT
<213>  Homo Sapiens

<400>  6445

Met Gly Glu Pro Gly Gln Ser Pro Ser Pro Arg Ser Ser His Gly Ser 
1               5                   10                  15      


Pro Pro Thr Leu Ser Thr Leu Thr Leu Leu Leu Leu Leu Cys Gly His 
            20                  25                  30          


Ala His Ser Gln Cys Lys Ile Leu Arg Cys Asn Ala Asp Ser Pro Ser 
        35                  40                  45              


Tyr Leu Arg Thr Cys Arg Asn Ala Leu Ile Arg Arg Cys Ile Arg Leu 
    50                  55                  60                  


Arg Trp Ile Ile Phe Leu 
65                  70  


<210>  6446
<211>  93
<212>  PRT
<213>  Homo Sapiens

<400>  6446

Met Gly Glu Pro Gly Gln Ser Pro Ser Pro Arg Ser Ser His Gly Ser 
1               5                   10                  15      


Pro Pro Thr Leu Ser Thr Leu Thr Leu Leu Leu Leu Leu Cys Gly His 
            20                  25                  30          


Ala His Ser Gln Cys Lys Ile Leu Arg Cys Asn Ala Glu Tyr Val Ser 
        35                  40                  45              


Ser Thr Leu Ser Leu Arg Gly Gly Gly Ser Ser Gly Ala Leu Arg Gly 
    50                  55                  60                  


Gly Gly Gly Gly Gly Arg Gly Gly Gly Val Gly Ser Gly Gly Leu Cys 
65                  70                  75                  80  


Arg Ala Leu Arg Ser Tyr Ala Leu Cys Thr Arg Arg Thr 
                85                  90              


<210>  6447
<211>  426
<212>  PRT
<213>  Homo Sapiens

<400>  6447

Met Gly Glu Pro Gly Gln Ser Pro Ser Pro Arg Ser Ser His Gly Ser 
1               5                   10                  15      


Pro Pro Thr Leu Ser Thr Leu Thr Leu Leu Leu Leu Leu Cys Gly His 
            20                  25                  30          


Ala His Ser Gln Cys Lys Ile Leu Arg Cys Asn Ala Glu Tyr Val Ser 
        35                  40                  45              


Ser Thr Leu Ser Leu Arg Gly Gly Gly Ser Ser Gly Ala Leu Arg Gly 
    50                  55                  60                  


Gly Gly Gly Gly Gly Arg Gly Gly Gly Val Gly Ser Gly Gly Leu Cys 
65                  70                  75                  80  


Arg Ala Leu Arg Ser Tyr Ala Leu Cys Thr Arg Arg Thr Ala Arg Thr 
                85                  90                  95      


Cys Arg Gly Asp Leu Ala Phe His Ser Ala Val His Gly Ile Glu Asp 
            100                 105                 110         


Leu Met Ile Gln His Asn Cys Ser Arg Gln Gly Pro Thr Ala Pro Pro 
        115                 120                 125             


Pro Pro Arg Gly Pro Ala Leu Pro Gly Ala Gly Ser Gly Leu Pro Ala 
    130                 135                 140                 


Pro Asp Pro Cys Asp Tyr Glu Gly Arg Phe Ser Arg Leu His Gly Arg 
145                 150                 155                 160 


Pro Pro Gly Phe Leu His Cys Ala Ser Phe Gly Asp Pro His Val Arg 
                165                 170                 175     


Ser Phe His His His Phe His Thr Cys Arg Val Gln Gly Ala Trp Pro 
            180                 185                 190         


Leu Leu Asp Asn Asp Phe Leu Phe Val Gln Ala Thr Ser Ser Pro Met 
        195                 200                 205             


Ala Leu Gly Ala Asn Ala Thr Ala Thr Arg Lys Leu Thr Ile Ile Phe 
    210                 215                 220                 


Lys Asn Met Gln Glu Cys Ile Asp Gln Lys Val Tyr Gln Ala Glu Val 
225                 230                 235                 240 


Asp Asn Leu Pro Val Ala Phe Glu Asp Gly Ser Ile Asn Gly Gly Asp 
                245                 250                 255     


Arg Pro Gly Gly Ser Ser Leu Ser Ile Gln Thr Ala Asn Pro Gly Asn 
            260                 265                 270         


His Val Glu Ile Gln Ala Ala Tyr Ile Gly Thr Thr Ile Ile Ile Arg 
        275                 280                 285             


Gln Thr Ala Gly Gln Leu Ser Phe Ser Ile Lys Val Ala Glu Asp Val 
    290                 295                 300                 


Ala Met Ala Phe Ser Ala Glu Gln Asp Leu Gln Leu Cys Val Gly Gly 
305                 310                 315                 320 


Cys Pro Pro Ser Gln Arg Leu Ser Arg Ser Glu Arg Asn Arg Arg Gly 
                325                 330                 335     


Ala Ile Thr Ile Asp Thr Ala Arg Arg Leu Cys Lys Glu Gly Leu Pro 
            340                 345                 350         


Val Glu Asp Ala Tyr Phe His Ser Cys Val Phe Asp Val Leu Ile Ser 
        355                 360                 365             


Gly Asp Pro Asn Phe Thr Val Ala Ala Gln Ala Ala Leu Glu Asp Ala 
    370                 375                 380                 


Arg Ala Phe Leu Pro Asp Leu Glu Lys Leu His Leu Phe Pro Ser Asp 
385                 390                 395                 400 


Ala Gly Val Pro Leu Ser Ser Ala Thr Leu Leu Ala Pro Leu Leu Ser 
                405                 410                 415     


Gly Leu Phe Val Leu Trp Leu Cys Ile Gln 
            420                 425     


<210>  6448
<211>  313
<212>  PRT
<213>  Homo Sapiens

<400>  6448

Met Ile Gln His Asn Cys Ser Arg Gln Gly Pro Thr Ala Pro Pro Pro 
1               5                   10                  15      


Pro Arg Gly Pro Ala Leu Pro Gly Ala Gly Ser Gly Leu Pro Ala Pro 
            20                  25                  30          


Asp Pro Cys Asp Tyr Glu Gly Arg Phe Ser Arg Leu His Gly Arg Pro 
        35                  40                  45              


Pro Gly Phe Leu His Cys Ala Ser Phe Gly Asp Pro His Val Arg Ser 
    50                  55                  60                  


Phe His His His Phe His Thr Cys Arg Val Gln Gly Ala Trp Pro Leu 
65                  70                  75                  80  


Leu Asp Asn Asp Phe Leu Phe Val Gln Ala Thr Ser Ser Pro Met Ala 
                85                  90                  95      


Leu Gly Ala Asn Ala Thr Ala Thr Arg Lys Leu Thr Ile Ile Phe Lys 
            100                 105                 110         


Asn Met Gln Glu Cys Ile Asp Gln Lys Val Tyr Gln Ala Glu Val Asp 
        115                 120                 125             


Asn Leu Pro Val Ala Phe Glu Asp Gly Ser Ile Asn Gly Gly Asp Arg 
    130                 135                 140                 


Pro Gly Gly Ser Ser Leu Ser Ile Gln Thr Ala Asn Pro Gly Asn His 
145                 150                 155                 160 


Val Glu Ile Gln Ala Ala Tyr Ile Gly Thr Thr Ile Ile Ile Arg Gln 
                165                 170                 175     


Thr Ala Gly Gln Leu Ser Phe Ser Ile Lys Val Ala Glu Asp Val Ala 
            180                 185                 190         


Met Ala Phe Ser Ala Glu Gln Asp Leu Gln Leu Cys Val Gly Gly Cys 
        195                 200                 205             


Pro Pro Ser Gln Arg Leu Ser Arg Ser Glu Arg Asn Arg Arg Gly Ala 
    210                 215                 220                 


Ile Thr Ile Asp Thr Ala Arg Arg Leu Cys Lys Glu Gly Leu Pro Val 
225                 230                 235                 240 


Glu Asp Ala Tyr Phe His Ser Cys Val Phe Asp Val Leu Ile Ser Gly 
                245                 250                 255     


Asp Pro Asn Phe Thr Val Ala Ala Gln Ala Ala Leu Glu Asp Ala Arg 
            260                 265                 270         


Ala Phe Leu Pro Asp Leu Glu Lys Leu His Leu Phe Pro Ser Asp Ala 
        275                 280                 285             


Gly Val Pro Leu Ser Ser Ala Thr Leu Leu Ala Pro Leu Leu Ser Gly 
    290                 295                 300                 


Leu Phe Val Leu Trp Leu Cys Ile Gln 
305                 310             


<210>  6449
<211>  200
<212>  PRT
<213>  Homo Sapiens

<400>  6449

Met Gln Glu Cys Ile Asp Gln Lys Val Tyr Gln Ala Glu Val Asp Asn 
1               5                   10                  15      


Leu Pro Val Ala Phe Glu Asp Gly Ser Ile Asn Gly Gly Asp Arg Pro 
            20                  25                  30          


Gly Gly Ser Ser Leu Ser Ile Gln Thr Ala Asn Pro Gly Asn His Val 
        35                  40                  45              


Glu Ile Gln Ala Ala Tyr Ile Gly Thr Thr Ile Ile Ile Arg Gln Thr 
    50                  55                  60                  


Ala Gly Gln Leu Ser Phe Ser Ile Lys Val Ala Glu Asp Val Ala Met 
65                  70                  75                  80  


Ala Phe Ser Ala Glu Gln Asp Leu Gln Leu Cys Val Gly Gly Cys Pro 
                85                  90                  95      


Pro Ser Gln Arg Leu Ser Arg Ser Glu Arg Asn Arg Arg Gly Ala Ile 
            100                 105                 110         


Thr Ile Asp Thr Ala Arg Arg Leu Cys Lys Glu Gly Leu Pro Val Glu 
        115                 120                 125             


Asp Ala Tyr Phe His Ser Cys Val Phe Asp Val Leu Ile Ser Gly Asp 
    130                 135                 140                 


Pro Asn Phe Thr Val Ala Ala Gln Ala Ala Leu Glu Asp Ala Arg Ala 
145                 150                 155                 160 


Phe Leu Pro Asp Leu Glu Lys Leu His Leu Phe Pro Ser Asp Ala Gly 
                165                 170                 175     


Val Pro Leu Ser Ser Ala Thr Leu Leu Ala Pro Leu Leu Ser Gly Leu 
            180                 185                 190         


Phe Val Leu Trp Leu Cys Ile Gln 
        195                 200 


<210>  6450
<211>  200
<212>  PRT
<213>  Homo Sapiens

<400>  6450

Met Gln Glu Cys Ile Asp Gln Lys Val Tyr Gln Ala Glu Val Asp Asn 
1               5                   10                  15      


Leu Pro Val Ala Phe Glu Asp Gly Ser Ile Asn Gly Gly Asp Arg Pro 
            20                  25                  30          


Gly Gly Ser Ser Leu Ser Ile Gln Thr Ala Asn Pro Gly Asn His Val 
        35                  40                  45              


Glu Ile Gln Ala Ala Tyr Ile Gly Thr Thr Ile Ile Ile Arg Gln Thr 
    50                  55                  60                  


Ala Gly Gln Leu Ser Phe Ser Ile Lys Val Ala Glu Asp Val Ala Met 
65                  70                  75                  80  


Ala Phe Ser Ala Glu Gln Asp Leu Gln Leu Cys Val Gly Gly Cys Pro 
                85                  90                  95      


Pro Ser Gln Arg Leu Ser Arg Ser Glu Arg Asn Arg Arg Gly Ala Ile 
            100                 105                 110         


Thr Ile Asp Thr Ala Arg Arg Leu Cys Lys Glu Gly Leu Pro Val Glu 
        115                 120                 125             


Asp Ala Tyr Phe His Ser Cys Val Phe Asp Val Leu Ile Ser Gly Asp 
    130                 135                 140                 


Pro Asn Phe Thr Val Ala Ala Gln Ala Ala Leu Glu Asp Ala Arg Ala 
145                 150                 155                 160 


Phe Leu Pro Asp Leu Glu Lys Leu His Leu Phe Pro Ser Asp Ala Gly 
                165                 170                 175     


Val Pro Leu Ser Ser Ala Thr Leu Leu Ala Pro Leu Leu Ser Gly Leu 
            180                 185                 190         


Phe Val Leu Trp Leu Cys Ile Gln 
        195                 200 


<210>  6451
<211>  200
<212>  PRT
<213>  Homo Sapiens

<400>  6451

Met Gln Glu Cys Ile Asp Gln Lys Val Tyr Gln Ala Glu Val Asp Asn 
1               5                   10                  15      


Leu Pro Val Ala Phe Glu Asp Gly Ser Ile Asn Gly Gly Asp Arg Pro 
            20                  25                  30          


Gly Gly Ser Ser Leu Ser Ile Gln Thr Ala Asn Pro Gly Asn His Val 
        35                  40                  45              


Glu Ile Gln Ala Ala Tyr Ile Gly Thr Thr Ile Ile Ile Arg Gln Thr 
    50                  55                  60                  


Ala Gly Gln Leu Ser Phe Ser Ile Lys Val Ala Glu Asp Val Ala Met 
65                  70                  75                  80  


Ala Phe Ser Ala Glu Gln Asp Leu Gln Leu Cys Val Gly Gly Cys Pro 
                85                  90                  95      


Pro Ser Gln Arg Leu Ser Arg Ser Glu Arg Asn Arg Arg Gly Ala Ile 
            100                 105                 110         


Thr Ile Asp Thr Ala Arg Arg Leu Cys Lys Glu Gly Leu Pro Val Glu 
        115                 120                 125             


Asp Ala Tyr Phe His Ser Cys Val Phe Asp Val Leu Ile Ser Gly Asp 
    130                 135                 140                 


Pro Asn Phe Thr Val Ala Ala Gln Ala Ala Leu Glu Asp Ala Arg Ala 
145                 150                 155                 160 


Phe Leu Pro Asp Leu Glu Lys Leu His Leu Phe Pro Ser Asp Ala Gly 
                165                 170                 175     


Val Pro Leu Ser Ser Ala Thr Leu Leu Ala Pro Leu Leu Ser Gly Leu 
            180                 185                 190         


Phe Val Leu Trp Leu Cys Ile Gln 
        195                 200 


<210>  6452
<211>  118
<212>  PRT
<213>  Homo Sapiens

<400>  6452

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu 
        115             


<210>  6453
<211>  141
<212>  PRT
<213>  Homo Sapiens

<400>  6453

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser 
    130                 135                 140     


<210>  6454
<211>  161
<212>  PRT
<213>  Homo Sapiens

<400>  6454

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 
    130                 135                 140                 


Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His 
145                 150                 155                 160 


Arg 
    


<210>  6455
<211>  210
<212>  PRT
<213>  Homo Sapiens

<400>  6455

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 
    130                 135                 140                 


Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His 
145                 150                 155                 160 


Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr 
                165                 170                 175     


Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser 
            180                 185                 190         


Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu 
        195                 200                 205             


Gly Lys 
    210 


<210>  6456
<211>  728
<212>  PRT
<213>  Homo Sapiens

<400>  6456

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 
    130                 135                 140                 


Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His 
145                 150                 155                 160 


Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr 
                165                 170                 175     


Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser 
            180                 185                 190         


Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu 
        195                 200                 205             


Val Glu Cys Met Thr Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met Asp 
    210                 215                 220                 


His Thr Glu Ser Gly Lys Ile Cys Gln Arg Trp Asp His Gln Thr Pro 
225                 230                 235                 240 


His Arg His Lys Phe Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe Asp 
                245                 250                 255     


Asp Asn Tyr Cys Arg Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys Tyr 
            260                 265                 270         


Thr Leu Asp Pro His Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr Cys 
        275                 280                 285             


Ala Asp Asn Thr Met Asn Asp Thr Asp Val Pro Leu Glu Thr Thr Glu 
    290                 295                 300                 


Cys Ile Gln Gly Gln Gly Glu Gly Tyr Arg Gly Thr Val Asn Thr Ile 
305                 310                 315                 320 


Trp Asn Gly Ile Pro Cys Gln Arg Trp Asp Ser Gln Tyr Pro His Glu 
                325                 330                 335     


His Asp Met Thr Pro Glu Asn Phe Lys Cys Lys Asp Leu Arg Glu Asn 
            340                 345                 350         


Tyr Cys Arg Asn Pro Asp Gly Ser Glu Ser Pro Trp Cys Phe Thr Thr 
        355                 360                 365             


Asp Pro Asn Ile Arg Val Gly Tyr Cys Ser Gln Ile Pro Asn Cys Asp 
    370                 375                 380                 


Met Ser His Gly Gln Asp Cys Tyr Arg Gly Asn Gly Lys Asn Tyr Met 
385                 390                 395                 400 


Gly Asn Leu Ser Gln Thr Arg Ser Gly Leu Thr Cys Ser Met Trp Asp 
                405                 410                 415     


Lys Asn Met Glu Asp Leu His Arg His Ile Phe Trp Glu Pro Asp Ala 
            420                 425                 430         


Ser Lys Leu Asn Glu Asn Tyr Cys Arg Asn Pro Asp Asp Asp Ala His 
        435                 440                 445             


Gly Pro Trp Cys Tyr Thr Gly Asn Pro Leu Ile Pro Trp Asp Tyr Cys 
    450                 455                 460                 


Pro Ile Ser Arg Cys Glu Gly Asp Thr Thr Pro Thr Ile Val Asn Leu 
465                 470                 475                 480 


Asp His Pro Val Ile Ser Cys Ala Lys Thr Lys Gln Leu Arg Val Val 
                485                 490                 495     


Asn Gly Ile Pro Thr Arg Thr Asn Ile Gly Trp Met Val Ser Leu Arg 
            500                 505                 510         


Tyr Arg Asn Lys His Ile Cys Gly Gly Ser Leu Ile Lys Glu Ser Trp 
        515                 520                 525             


Val Leu Thr Ala Arg Gln Cys Phe Pro Ser Arg Asp Leu Lys Asp Tyr 
    530                 535                 540                 


Glu Ala Trp Leu Gly Ile His Asp Val His Gly Arg Gly Asp Glu Lys 
545                 550                 555                 560 


Cys Lys Gln Val Leu Asn Val Ser Gln Leu Val Tyr Gly Pro Glu Gly 
                565                 570                 575     


Ser Asp Leu Val Leu Met Lys Leu Ala Arg Pro Ala Val Leu Asp Asp 
            580                 585                 590         


Phe Val Ser Thr Ile Asp Leu Pro Asn Tyr Gly Cys Thr Ile Pro Glu 
        595                 600                 605             


Lys Thr Ser Cys Ser Val Tyr Gly Trp Gly Tyr Thr Gly Leu Ile Asn 
    610                 615                 620                 


Tyr Asp Gly Leu Leu Arg Val Ala His Leu Tyr Ile Met Gly Asn Glu 
625                 630                 635                 640 


Lys Cys Ser Gln His His Arg Gly Lys Val Thr Leu Asn Glu Ser Glu 
                645                 650                 655     


Ile Cys Ala Gly Ala Glu Lys Ile Gly Ser Gly Pro Cys Glu Gly Asp 
            660                 665                 670         


Tyr Gly Gly Pro Leu Val Cys Glu Gln His Lys Met Arg Met Val Leu 
        675                 680                 685             


Gly Val Ile Val Pro Gly Arg Gly Cys Ala Ile Pro Asn Arg Pro Gly 
    690                 695                 700                 


Ile Phe Val Arg Val Ala Tyr Tyr Ala Lys Trp Ile His Lys Ile Ile 
705                 710                 715                 720 


Leu Thr Tyr Lys Val Pro Gln Ser 
                725             


<210>  6457
<211>  290
<212>  PRT
<213>  Homo Sapiens

<400>  6457

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 
    130                 135                 140                 


Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His 
145                 150                 155                 160 


Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr 
                165                 170                 175     


Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser 
            180                 185                 190         


Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu 
        195                 200                 205             


Val Glu Cys Met Thr Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met Asp 
    210                 215                 220                 


His Thr Glu Ser Gly Lys Ile Cys Gln Arg Trp Asp His Gln Thr Pro 
225                 230                 235                 240 


His Arg His Lys Phe Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe Asp 
                245                 250                 255     


Asp Asn Tyr Cys Arg Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys Tyr 
            260                 265                 270         


Thr Leu Asp Pro His Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr Cys 
        275                 280                 285             


Glu Thr 
    290 


<210>  6458
<211>  728
<212>  PRT
<213>  Homo Sapiens

<400>  6458

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 
    130                 135                 140                 


Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His 
145                 150                 155                 160 


Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr 
                165                 170                 175     


Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser 
            180                 185                 190         


Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu 
        195                 200                 205             


Val Glu Cys Met Thr Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met Asp 
    210                 215                 220                 


His Thr Glu Ser Gly Lys Ile Cys Gln Arg Trp Asp His Gln Thr Pro 
225                 230                 235                 240 


His Arg His Lys Phe Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe Asp 
                245                 250                 255     


Asp Asn Tyr Cys Arg Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys Tyr 
            260                 265                 270         


Thr Leu Asp Pro His Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr Cys 
        275                 280                 285             


Ala Asp Asn Thr Met Asn Asp Thr Asp Val Pro Leu Glu Thr Thr Glu 
    290                 295                 300                 


Cys Ile Gln Gly Gln Gly Glu Gly Tyr Arg Gly Thr Val Asn Thr Ile 
305                 310                 315                 320 


Trp Asn Gly Ile Pro Cys Gln Arg Trp Asp Ser Gln Tyr Pro His Glu 
                325                 330                 335     


His Asp Met Thr Pro Glu Asn Phe Lys Cys Lys Asp Leu Arg Glu Asn 
            340                 345                 350         


Tyr Cys Arg Asn Pro Asp Gly Ser Glu Ser Pro Trp Cys Phe Thr Thr 
        355                 360                 365             


Asp Pro Asn Ile Arg Val Gly Tyr Cys Ser Gln Ile Pro Asn Cys Asp 
    370                 375                 380                 


Met Ser His Gly Gln Asp Cys Tyr Arg Gly Asn Gly Lys Asn Tyr Met 
385                 390                 395                 400 


Gly Asn Leu Ser Gln Thr Arg Ser Gly Leu Thr Cys Ser Met Trp Asp 
                405                 410                 415     


Lys Asn Met Glu Asp Leu His Arg His Ile Phe Trp Glu Pro Asp Ala 
            420                 425                 430         


Ser Lys Leu Asn Glu Asn Tyr Cys Arg Asn Pro Asp Asp Asp Ala His 
        435                 440                 445             


Gly Pro Trp Cys Tyr Thr Gly Asn Pro Leu Ile Pro Trp Asp Tyr Cys 
    450                 455                 460                 


Pro Ile Ser Arg Cys Glu Gly Asp Thr Thr Pro Thr Ile Val Asn Leu 
465                 470                 475                 480 


Asp His Pro Val Ile Ser Cys Ala Lys Thr Lys Gln Leu Arg Val Val 
                485                 490                 495     


Asn Gly Ile Pro Thr Arg Thr Asn Ile Gly Trp Met Val Ser Leu Arg 
            500                 505                 510         


Tyr Arg Asn Lys His Ile Cys Gly Gly Ser Leu Ile Lys Glu Ser Trp 
        515                 520                 525             


Val Leu Thr Ala Arg Gln Cys Phe Pro Ser Arg Asp Leu Lys Asp Tyr 
    530                 535                 540                 


Glu Ala Trp Leu Gly Ile His Asp Val His Gly Arg Gly Asp Glu Lys 
545                 550                 555                 560 


Cys Lys Gln Val Leu Asn Val Ser Gln Leu Val Tyr Gly Pro Glu Gly 
                565                 570                 575     


Ser Asp Leu Val Leu Met Lys Leu Ala Arg Pro Ala Val Leu Asp Asp 
            580                 585                 590         


Phe Val Ser Thr Ile Asp Leu Pro Asn Tyr Gly Cys Thr Ile Pro Glu 
        595                 600                 605             


Lys Thr Ser Cys Ser Val Tyr Gly Trp Gly Tyr Thr Gly Leu Ile Asn 
    610                 615                 620                 


Tyr Asp Gly Leu Leu Arg Val Ala His Leu Tyr Ile Met Gly Asn Glu 
625                 630                 635                 640 


Lys Cys Ser Gln His His Arg Gly Lys Val Thr Leu Asn Glu Ser Glu 
                645                 650                 655     


Ile Cys Ala Gly Ala Glu Lys Ile Gly Ser Gly Pro Cys Glu Gly Asp 
            660                 665                 670         


Tyr Gly Gly Pro Leu Val Cys Glu Gln His Lys Met Arg Met Val Leu 
        675                 680                 685             


Gly Val Ile Val Pro Gly Arg Gly Cys Ala Ile Pro Asn Arg Pro Gly 
    690                 695                 700                 


Ile Phe Val Arg Val Ala Tyr Tyr Ala Lys Trp Ile His Lys Ile Ile 
705                 710                 715                 720 


Leu Thr Tyr Lys Val Pro Gln Ser 
                725             


<210>  6459
<211>  184
<212>  PRT
<213>  Homo Sapiens

<400>  6459

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 
    130                 135                 140                 


Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His 
145                 150                 155                 160 


Ser Gly Gly Asp Asp Cys Leu Val Glu Ser Thr Phe Tyr Ser Ile Pro 
                165                 170                 175     


Phe Trp Gly His Asn Ser Ala Arg 
            180                 


<210>  6460
<211>  205
<212>  PRT
<213>  Homo Sapiens

<400>  6460

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 
    130                 135                 140                 


Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His 
145                 150                 155                 160 


Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr Cys Arg Asn Pro Arg 
                165                 170                 175     


Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser Asn Pro Glu Val Arg 
            180                 185                 190         


Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu Gly Lys 
        195                 200                 205 


<210>  6461
<211>  285
<212>  PRT
<213>  Homo Sapiens

<400>  6461

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 
    130                 135                 140                 


Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His 
145                 150                 155                 160 


Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr Cys Arg Asn Pro Arg 
                165                 170                 175     


Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser Asn Pro Glu Val Arg 
            180                 185                 190         


Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu Val Glu Cys Met Thr 
        195                 200                 205             


Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met Asp His Thr Glu Ser Gly 
    210                 215                 220                 


Lys Ile Cys Gln Arg Trp Asp His Gln Thr Pro His Arg His Lys Phe 
225                 230                 235                 240 


Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe Asp Asp Asn Tyr Cys Arg 
                245                 250                 255     


Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys Tyr Thr Leu Asp Pro His 
            260                 265                 270         


Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr Cys Glu Thr 
        275                 280                 285 


<210>  6462
<211>  723
<212>  PRT
<213>  Homo Sapiens

<400>  6462

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 
    130                 135                 140                 


Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His 
145                 150                 155                 160 


Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr Cys Arg Asn Pro Arg 
                165                 170                 175     


Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser Asn Pro Glu Val Arg 
            180                 185                 190         


Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu Val Glu Cys Met Thr 
        195                 200                 205             


Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met Asp His Thr Glu Ser Gly 
    210                 215                 220                 


Lys Ile Cys Gln Arg Trp Asp His Gln Thr Pro His Arg His Lys Phe 
225                 230                 235                 240 


Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe Asp Asp Asn Tyr Cys Arg 
                245                 250                 255     


Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys Tyr Thr Leu Asp Pro His 
            260                 265                 270         


Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr Cys Ala Asp Asn Thr Met 
        275                 280                 285             


Asn Asp Thr Asp Val Pro Leu Glu Thr Thr Glu Cys Ile Gln Gly Gln 
    290                 295                 300                 


Gly Glu Gly Tyr Arg Gly Thr Val Asn Thr Ile Trp Asn Gly Ile Pro 
305                 310                 315                 320 


Cys Gln Arg Trp Asp Ser Gln Tyr Pro His Glu His Asp Met Thr Pro 
                325                 330                 335     


Glu Asn Phe Lys Cys Lys Asp Leu Arg Glu Asn Tyr Cys Arg Asn Pro 
            340                 345                 350         


Asp Gly Ser Glu Ser Pro Trp Cys Phe Thr Thr Asp Pro Asn Ile Arg 
        355                 360                 365             


Val Gly Tyr Cys Ser Gln Ile Pro Asn Cys Asp Met Ser His Gly Gln 
    370                 375                 380                 


Asp Cys Tyr Arg Gly Asn Gly Lys Asn Tyr Met Gly Asn Leu Ser Gln 
385                 390                 395                 400 


Thr Arg Ser Gly Leu Thr Cys Ser Met Trp Asp Lys Asn Met Glu Asp 
                405                 410                 415     


Leu His Arg His Ile Phe Trp Glu Pro Asp Ala Ser Lys Leu Asn Glu 
            420                 425                 430         


Asn Tyr Cys Arg Asn Pro Asp Asp Asp Ala His Gly Pro Trp Cys Tyr 
        435                 440                 445             


Thr Gly Asn Pro Leu Ile Pro Trp Asp Tyr Cys Pro Ile Ser Arg Cys 
    450                 455                 460                 


Glu Gly Asp Thr Thr Pro Thr Ile Val Asn Leu Asp His Pro Val Ile 
465                 470                 475                 480 


Ser Cys Ala Lys Thr Lys Gln Leu Arg Val Val Asn Gly Ile Pro Thr 
                485                 490                 495     


Arg Thr Asn Ile Gly Trp Met Val Ser Leu Arg Tyr Arg Asn Lys His 
            500                 505                 510         


Ile Cys Gly Gly Ser Leu Ile Lys Glu Ser Trp Val Leu Thr Ala Arg 
        515                 520                 525             


Gln Cys Phe Pro Ser Arg Asp Leu Lys Asp Tyr Glu Ala Trp Leu Gly 
    530                 535                 540                 


Ile His Asp Val His Gly Arg Gly Asp Glu Lys Cys Lys Gln Val Leu 
545                 550                 555                 560 


Asn Val Ser Gln Leu Val Tyr Gly Pro Glu Gly Ser Asp Leu Val Leu 
                565                 570                 575     


Met Lys Leu Ala Arg Pro Ala Val Leu Asp Asp Phe Val Ser Thr Ile 
            580                 585                 590         


Asp Leu Pro Asn Tyr Gly Cys Thr Ile Pro Glu Lys Thr Ser Cys Ser 
        595                 600                 605             


Val Tyr Gly Trp Gly Tyr Thr Gly Leu Ile Asn Tyr Asp Gly Leu Leu 
    610                 615                 620                 


Arg Val Ala His Leu Tyr Ile Met Gly Asn Glu Lys Cys Ser Gln His 
625                 630                 635                 640 


His Arg Gly Lys Val Thr Leu Asn Glu Ser Glu Ile Cys Ala Gly Ala 
                645                 650                 655     


Glu Lys Ile Gly Ser Gly Pro Cys Glu Gly Asp Tyr Gly Gly Pro Leu 
            660                 665                 670         


Val Cys Glu Gln His Lys Met Arg Met Val Leu Gly Val Ile Val Pro 
        675                 680                 685             


Gly Arg Gly Cys Ala Ile Pro Asn Arg Pro Gly Ile Phe Val Arg Val 
    690                 695                 700                 


Ala Tyr Tyr Ala Lys Trp Ile His Lys Ile Ile Leu Thr Tyr Lys Val 
705                 710                 715                 720 


Pro Gln Ser 
            


<210>  6463
<211>  655
<212>  PRT
<213>  Homo Sapiens

<400>  6463

Met Gly Arg Trp Ala Trp Val Pro Ser Pro Trp Pro Pro Pro Gly Leu 
1               5                   10                  15      


Gly Pro Phe Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Pro Arg Gly 
            20                  25                  30          


Phe Gln Pro Gln Pro Gly Gly Asn Arg Thr Glu Ser Pro Glu Pro Asn 
        35                  40                  45              


Ala Thr Ala Thr Pro Ala Ile Pro Thr Ile Leu Val Thr Ser Val Thr 
    50                  55                  60                  


Ser Glu Thr Pro Ala Thr Ser Ala Pro Glu Ala Glu Gly Pro Gln Ser 
65                  70                  75                  80  


Gly Gly Leu Pro Pro Pro Pro Arg Ala Val Pro Ser Ser Ser Ser Pro 
                85                  90                  95      


Gln Ala Gln Ala Leu Thr Glu Asp Gly Arg Pro Cys Arg Phe Pro Phe 
            100                 105                 110         


Arg Tyr Gly Gly Arg Met Leu His Ala Cys Thr Ser Glu Gly Ser Ala 
        115                 120                 125             


His Arg Lys Trp Cys Ala Thr Thr His Asn Tyr Asp Arg Asp Arg Ala 
    130                 135                 140                 


Trp Gly Tyr Cys Val Glu Ala Thr Pro Pro Pro Gly Gly Pro Ala Ala 
145                 150                 155                 160 


Leu Asp Pro Cys Ala Ser Gly Pro Cys Leu Asn Gly Gly Ser Cys Ser 
                165                 170                 175     


Asn Thr Gln Asp Pro Gln Ser Tyr His Cys Ser Cys Pro Arg Ala Phe 
            180                 185                 190         


Thr Gly Lys Asp Cys Gly Thr Glu Lys Cys Phe Asp Glu Thr Arg Tyr 
        195                 200                 205             


Glu Tyr Leu Glu Gly Gly Asp Arg Trp Ala Arg Val Arg Gln Gly His 
    210                 215                 220                 


Val Glu Gln Cys Glu Cys Phe Gly Gly Arg Thr Trp Cys Glu Gly Thr 
225                 230                 235                 240 


Arg His Thr Ala Cys Leu Ser Ser Pro Cys Leu Asn Gly Gly Thr Cys 
                245                 250                 255     


His Leu Ile Val Ala Thr Gly Thr Thr Val Cys Ala Cys Pro Pro Gly 
            260                 265                 270         


Phe Ala Gly Arg Leu Cys Asn Ile Glu Pro Asp Glu Arg Cys Phe Leu 
        275                 280                 285             


Gly Asn Gly Thr Gly Tyr Arg Gly Val Ala Ser Thr Ser Ala Ser Gly 
    290                 295                 300                 


Leu Ser Cys Leu Ala Trp Asn Ser Asp Leu Leu Tyr Gln Glu Leu His 
305                 310                 315                 320 


Val Asp Ser Val Gly Ala Ala Ala Leu Leu Gly Leu Gly Pro His Ala 
                325                 330                 335     


Tyr Cys Arg Asn Pro Asp Asn Asp Glu Arg Pro Trp Cys Tyr Val Val 
            340                 345                 350         


Lys Asp Ser Ala Leu Ser Trp Glu Tyr Cys Arg Leu Glu Ala Cys Glu 
        355                 360                 365             


Ser Leu Thr Arg Val Gln Leu Ser Pro Asp Leu Leu Ala Thr Leu Pro 
    370                 375                 380                 


Glu Pro Ala Ser Pro Gly Arg Gln Ala Cys Gly Arg Arg His Lys Lys 
385                 390                 395                 400 


Arg Thr Phe Leu Arg Pro Arg Ile Ile Gly Gly Ser Ser Ser Leu Pro 
                405                 410                 415     


Gly Ser His Pro Trp Leu Ala Ala Ile Tyr Ile Gly Asp Ser Phe Cys 
            420                 425                 430         


Ala Gly Ser Leu Val His Thr Cys Trp Val Val Ser Ala Ala His Cys 
        435                 440                 445             


Phe Ser His Ser Pro Pro Arg Asp Ser Val Ser Val Val Leu Gly Gln 
    450                 455                 460                 


His Phe Phe Asn Arg Thr Thr Asp Val Thr Gln Thr Phe Gly Ile Glu 
465                 470                 475                 480 


Lys Tyr Ile Pro Tyr Thr Leu Tyr Ser Val Phe Asn Pro Ser Asp His 
                485                 490                 495     


Asp Leu Val Leu Ile Arg Leu Lys Lys Lys Gly Asp Arg Cys Ala Thr 
            500                 505                 510         


Arg Ser Gln Phe Val Gln Pro Ile Cys Leu Pro Glu Pro Gly Ser Thr 
        515                 520                 525             


Phe Pro Ala Gly His Lys Cys Gln Ile Ala Gly Trp Gly His Leu Asp 
    530                 535                 540                 


Glu Asn Val Ser Gly Tyr Ser Ser Ser Leu Arg Glu Ala Leu Val Pro 
545                 550                 555                 560 


Leu Val Ala Asp His Lys Cys Ser Ser Pro Glu Val Tyr Gly Ala Asp 
                565                 570                 575     


Ile Ser Pro Asn Met Leu Cys Ala Gly Tyr Phe Asp Cys Lys Ser Asp 
            580                 585                 590         


Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Ala Cys Glu Lys Asn Gly 
        595                 600                 605             


Val Ala Tyr Leu Tyr Gly Ile Ile Ser Trp Gly Asp Gly Cys Gly Arg 
    610                 615                 620                 


Leu His Lys Pro Gly Val Tyr Thr Arg Val Ala Asn Tyr Val Asp Trp 
625                 630                 635                 640 


Ile Asn Asp Arg Ile Arg Pro Pro Arg Arg Leu Val Ala Pro Ser 
                645                 650                 655 


<210>  6464
<211>  662
<212>  PRT
<213>  Homo Sapiens

<400>  6464

Met Gly Arg Trp Ala Trp Val Pro Ser Pro Trp Pro Pro Pro Gly Leu 
1               5                   10                  15      


Gly Pro Phe Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Pro Arg Gly 
            20                  25                  30          


Phe Gln Pro Gln Pro Gly Gly Asn Arg Thr Glu Ser Pro Glu Pro Asn 
        35                  40                  45              


Ala Thr Ala Thr Pro Ala Ile Pro Thr Ile Leu Val Thr Ser Val Thr 
    50                  55                  60                  


Ser Glu Thr Pro Ala Thr Ser Ala Pro Glu Ala Glu Gly Pro Gln Ser 
65                  70                  75                  80  


Gly Gly Leu Pro Pro Pro Pro Arg Ala Val Pro Ser Ser Ser Ser Pro 
                85                  90                  95      


Gln Ala Gln Ala Leu Thr Glu Asp Gly Arg Pro Cys Arg Phe Pro Phe 
            100                 105                 110         


Arg Tyr Gly Gly Arg Met Leu His Ala Cys Thr Ser Glu Gly Ser Ala 
        115                 120                 125             


His Arg Lys Trp Cys Ala Thr Thr His Asn Tyr Asp Arg Asp Arg Ala 
    130                 135                 140                 


Trp Gly Tyr Cys Val Glu Ala Thr Pro Pro Pro Gly Gly Pro Ala Ala 
145                 150                 155                 160 


Leu Asp Pro Cys Ala Ser Gly Pro Cys Leu Asn Gly Gly Ser Cys Ser 
                165                 170                 175     


Asn Thr Gln Asp Pro Gln Ser Tyr His Cys Ser Cys Pro Arg Ala Phe 
            180                 185                 190         


Thr Gly Lys Asp Cys Gly Thr Glu Lys Cys Phe Asp Glu Thr Arg Tyr 
        195                 200                 205             


Glu Tyr Leu Glu Gly Gly Asp Arg Trp Ala Arg Val Arg Gln Gly His 
    210                 215                 220                 


Val Glu Gln Cys Glu Cys Phe Gly Gly Arg Thr Trp Cys Glu Gly Thr 
225                 230                 235                 240 


Arg His Thr Ala Cys Leu Ser Ser Pro Cys Leu Asn Gly Gly Thr Cys 
                245                 250                 255     


His Leu Ile Val Ala Thr Gly Thr Thr Val Cys Ala Cys Pro Pro Gly 
            260                 265                 270         


Phe Ala Gly Arg Leu Cys Asn Ile Glu Pro Asp Glu Arg Cys Phe Leu 
        275                 280                 285             


Gly Asn Gly Thr Gly Tyr Arg Gly Val Ala Ser Thr Ser Ala Ser Gly 
    290                 295                 300                 


Leu Ser Cys Leu Ala Trp Asn Ser Asp Leu Leu Tyr Gln Glu Leu His 
305                 310                 315                 320 


Val Asp Ser Val Gly Ala Ala Ala Leu Leu Gly Leu Gly Pro His Ala 
                325                 330                 335     


Tyr Cys Arg Asn Pro Asp Asn Asp Glu Arg Pro Trp Cys Tyr Val Val 
            340                 345                 350         


Lys Asp Ser Ala Leu Ser Trp Glu Tyr Cys Arg Leu Glu Ala Cys Asp 
        355                 360                 365             


Leu Glu Thr Glu Gly Arg Glu Ser Leu Thr Arg Val Gln Leu Ser Pro 
    370                 375                 380                 


Asp Leu Leu Ala Thr Leu Pro Glu Pro Ala Ser Pro Gly Arg Gln Ala 
385                 390                 395                 400 


Cys Gly Arg Arg His Lys Lys Arg Thr Phe Leu Arg Pro Arg Ile Ile 
                405                 410                 415     


Gly Gly Ser Ser Ser Leu Pro Gly Ser His Pro Trp Leu Ala Ala Ile 
            420                 425                 430         


Tyr Ile Gly Asp Ser Phe Cys Ala Gly Ser Leu Val His Thr Cys Trp 
        435                 440                 445             


Val Val Ser Ala Ala His Cys Phe Ser His Ser Pro Pro Arg Asp Ser 
    450                 455                 460                 


Val Ser Val Val Leu Gly Gln His Phe Phe Asn Arg Thr Thr Asp Val 
465                 470                 475                 480 


Thr Gln Thr Phe Gly Ile Glu Lys Tyr Ile Pro Tyr Thr Leu Tyr Ser 
                485                 490                 495     


Val Phe Asn Pro Ser Asp His Asp Leu Val Leu Ile Arg Leu Lys Lys 
            500                 505                 510         


Lys Gly Asp Arg Cys Ala Thr Arg Ser Gln Phe Val Gln Pro Ile Cys 
        515                 520                 525             


Leu Pro Glu Pro Gly Ser Thr Phe Pro Ala Gly His Lys Cys Gln Ile 
    530                 535                 540                 


Ala Gly Trp Gly His Leu Asp Glu Asn Val Ser Gly Tyr Ser Ser Ser 
545                 550                 555                 560 


Leu Arg Glu Ala Leu Val Pro Leu Val Ala Asp His Lys Cys Ser Ser 
                565                 570                 575     


Pro Glu Val Tyr Gly Ala Asp Ile Ser Pro Asn Met Leu Cys Ala Gly 
            580                 585                 590         


Tyr Phe Asp Cys Lys Ser Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro 
        595                 600                 605             


Leu Ala Cys Glu Lys Asn Gly Val Ala Tyr Leu Tyr Gly Ile Ile Ser 
    610                 615                 620                 


Trp Gly Asp Gly Cys Gly Arg Leu His Lys Pro Gly Val Tyr Thr Arg 
625                 630                 635                 640 


Val Ala Asn Tyr Val Asp Trp Ile Asn Asp Arg Ile Arg Pro Pro Arg 
                645                 650                 655     


Arg Leu Val Ala Pro Ser 
            660         


<210>  6465
<211>  700
<212>  PRT
<213>  Homo Sapiens

<400>  6465

Met Leu Lys Met Leu Ser Phe Lys Leu Leu Leu Leu Ala Val Ala Leu 
1               5                   10                  15      


Gly Phe Phe Glu Gly Asp Ala Lys Phe Gly Glu Arg Asn Glu Gly Ser 
            20                  25                  30          


Gly Ala Arg Arg Arg Arg Cys Leu Asn Gly Asn Pro Pro Lys Arg Leu 
        35                  40                  45              


Lys Arg Arg Asp Arg Arg Met Met Ser Gln Leu Glu Leu Leu Ser Gly 
    50                  55                  60                  


Gly Glu Met Leu Cys Gly Gly Phe Tyr Pro Arg Leu Ser Cys Cys Leu 
65                  70                  75                  80  


Arg Ser Asp Ser Pro Gly Leu Gly Arg Leu Glu Asn Lys Ile Phe Ser 
                85                  90                  95      


Val Thr Asn Asn Thr Glu Cys Gly Lys Leu Leu Glu Glu Ile Lys Cys 
            100                 105                 110         


Ala Leu Cys Ser Pro His Ser Gln Ser Leu Phe His Ser Pro Glu Arg 
        115                 120                 125             


Glu Val Leu Glu Arg Asp Leu Val Leu Pro Leu Leu Cys Lys Asp Tyr 
    130                 135                 140                 


Cys Lys Glu Phe Phe Tyr Thr Cys Arg Gly His Ile Pro Gly Phe Leu 
145                 150                 155                 160 


Gln Thr Thr Ala Asp Glu Phe Cys Phe Tyr Tyr Ala Arg Lys Asp Gly 
                165                 170                 175     


Gly Leu Cys Phe Pro Asp Phe Pro Arg Lys Gln Val Arg Gly Pro Ala 
            180                 185                 190         


Ser Asn Tyr Leu Asp Gln Met Glu Glu Tyr Asp Lys Val Glu Glu Ile 
        195                 200                 205             


Ser Arg Lys His Lys His Asn Cys Phe Cys Ile Gln Glu Val Val Ser 
    210                 215                 220                 


Gly Leu Arg Gln Pro Val Gly Ala Leu His Ser Gly Asp Gly Ser Gln 
225                 230                 235                 240 


Arg Leu Phe Ile Leu Glu Lys Glu Gly Tyr Val Lys Ile Leu Thr Pro 
                245                 250                 255     


Glu Gly Glu Ile Phe Lys Glu Pro Tyr Leu Asp Ile His Lys Leu Val 
            260                 265                 270         


Gln Ser Gly Ile Lys Gly Gly Asp Glu Arg Gly Leu Leu Ser Leu Ala 
        275                 280                 285             


Phe His Pro Asn Tyr Lys Lys Asn Gly Lys Leu Tyr Val Ser Tyr Thr 
    290                 295                 300                 


Thr Asn Gln Glu Arg Trp Ala Ile Gly Pro His Asp His Ile Leu Arg 
305                 310                 315                 320 


Val Val Glu Tyr Thr Val Ser Arg Lys Asn Pro His Gln Val Asp Leu 
                325                 330                 335     


Arg Thr Ala Arg Val Phe Leu Glu Val Ala Glu Leu His Arg Lys His 
            340                 345                 350         


Leu Gly Gly Gln Leu Leu Phe Gly Pro Asp Gly Phe Leu Tyr Ile Ile 
        355                 360                 365             


Leu Gly Asp Gly Met Ile Thr Leu Asp Asp Met Glu Glu Met Asp Gly 
    370                 375                 380                 


Leu Ser Asp Phe Thr Gly Ser Val Leu Arg Leu Asp Val Asp Thr Asp 
385                 390                 395                 400 


Met Cys Asn Val Pro Tyr Ser Ile Pro Arg Ser Asn Pro His Phe Asn 
                405                 410                 415     


Ser Thr Asn Gln Pro Pro Glu Val Phe Ala His Gly Leu His Asp Pro 
            420                 425                 430         


Gly Arg Cys Ala Val Asp Arg His Pro Thr Asp Ile Asn Ile Asn Leu 
        435                 440                 445             


Thr Ile Leu Cys Ser Asp Ser Asn Gly Lys Asn Arg Ser Ser Ala Arg 
    450                 455                 460                 


Ile Leu Gln Ile Ile Lys Gly Lys Asp Tyr Glu Ser Glu Pro Ser Leu 
465                 470                 475                 480 


Leu Glu Phe Lys Pro Phe Ser Asn Gly Pro Leu Val Gly Gly Phe Val 
                485                 490                 495     


Tyr Arg Gly Cys Gln Ser Glu Arg Leu Tyr Gly Ser Tyr Val Phe Gly 
            500                 505                 510         


Asp Arg Asn Gly Asn Phe Leu Thr Leu Gln Gln Ser Pro Val Thr Lys 
        515                 520                 525             


Gln Trp Gln Glu Lys Pro Leu Cys Leu Gly Thr Ser Gly Ser Cys Arg 
    530                 535                 540                 


Gly Tyr Phe Ser Gly His Ile Leu Gly Phe Gly Glu Asp Glu Leu Gly 
545                 550                 555                 560 


Glu Val Tyr Ile Leu Ser Ser Ser Lys Ser Met Thr Gln Thr His Asn 
                565                 570                 575     


Gly Lys Leu Tyr Lys Ile Val Asp Pro Lys Arg Pro Leu Met Pro Glu 
            580                 585                 590         


Glu Cys Arg Ala Thr Val Gln Pro Ala Gln Thr Leu Thr Ser Glu Cys 
        595                 600                 605             


Ser Arg Leu Cys Arg Asn Gly Tyr Cys Thr Pro Thr Gly Lys Cys Cys 
    610                 615                 620                 


Cys Ser Pro Gly Trp Glu Gly Asp Phe Cys Arg Thr Ala Lys Cys Glu 
625                 630                 635                 640 


Pro Ala Cys Arg His Gly Gly Val Cys Val Arg Pro Asn Lys Cys Leu 
                645                 650                 655     


Cys Lys Lys Gly Tyr Leu Gly Pro Gln Cys Glu Gln Val Asp Arg Asn 
            660                 665                 670         


Ile Arg Arg Val Thr Arg Ala Gly Ile Leu Asp Gln Ile Ile Asp Met 
        675                 680                 685             


Thr Ser Tyr Leu Leu Asp Leu Thr Ser Tyr Ile Val 
    690                 695                 700 


<210>  6466
<211>  320
<212>  PRT
<213>  Homo Sapiens

<400>  6466

Met Leu Lys Met Leu Ser Phe Lys Leu Leu Leu Leu Ala Val Ala Leu 
1               5                   10                  15      


Gly Phe Phe Glu Gly Asp Ala Lys Phe Gly Glu Arg Asn Glu Gly Ser 
            20                  25                  30          


Gly Ala Arg Arg Arg Arg Cys Leu Asn Gly Asn Pro Pro Lys Arg Leu 
        35                  40                  45              


Lys Arg Arg Asp Arg Arg Met Met Ser Gln Leu Glu Leu Leu Ser Gly 
    50                  55                  60                  


Gly Glu Met Leu Cys Gly Gly Phe Tyr Pro Arg Leu Ser Cys Cys Leu 
65                  70                  75                  80  


Arg Ser Asp Ser Pro Gly Leu Gly Arg Leu Glu Asn Lys Ile Phe Ser 
                85                  90                  95      


Val Thr Asn Asn Thr Glu Cys Gly Lys Leu Leu Glu Glu Ile Lys Cys 
            100                 105                 110         


Ala Leu Cys Ser Pro His Ser Gln Ser Leu Phe His Ser Pro Glu Arg 
        115                 120                 125             


Glu Val Leu Glu Arg Asp Leu Val Leu Pro Leu Leu Cys Lys Asp Tyr 
    130                 135                 140                 


Cys Lys Glu Phe Phe Tyr Thr Cys Arg Gly His Ile Pro Gly Phe Leu 
145                 150                 155                 160 


Gln Thr Thr Ala Asp Glu Phe Cys Phe Tyr Tyr Ala Arg Lys Asp Gly 
                165                 170                 175     


Gly Leu Cys Phe Pro Asp Phe Pro Arg Lys Gln Val Arg Gly Pro Ala 
            180                 185                 190         


Ser Asn Tyr Leu Asp Gln Met Glu Glu Tyr Asp Lys Val Glu Glu Ile 
        195                 200                 205             


Ser Arg Lys His Lys His Asn Cys Phe Cys Ile Gln Glu Val Val Ser 
    210                 215                 220                 


Gly Leu Arg Gln Pro Val Gly Ala Leu His Ser Gly Asp Gly Ser Gln 
225                 230                 235                 240 


Arg Leu Phe Ile Leu Glu Lys Glu Gly Tyr Val Lys Ile Leu Thr Pro 
                245                 250                 255     


Glu Gly Glu Ile Phe Lys Glu Pro Tyr Leu Asp Ile His Lys Leu Val 
            260                 265                 270         


Gln Ser Gly Ile Lys Val Gly Phe Leu Asn Phe Ile Tyr Phe Cys Ala 
        275                 280                 285             


Gly Tyr Val Asn Phe Ile Leu Val Leu Pro Ser Ser Leu Lys Val Phe 
    290                 295                 300                 


Leu Cys Asn Lys Arg Lys Asn Leu Ala Gly Glu Asn Lys Gly Ala Thr 
305                 310                 315                 320 


<210>  6467
<211>  782
<212>  PRT
<213>  Homo Sapiens

<400>  6467

Met Ala Arg Ala Arg Ala Gly Ala Leu Leu Ala Leu Trp Val Leu Gly 
1               5                   10                  15      


Ala Ala Ala His Pro Gln Cys Leu Asp Phe Arg Pro Pro Phe Arg Pro 
            20                  25                  30          


Thr Gln Pro Leu Arg Leu Cys Ala Gln Tyr Ser Asp Phe Gly Cys Cys 
        35                  40                  45              


Asp Glu Gly Arg Asp Ala Glu Leu Thr Arg Arg Phe Trp Ala Leu Ala 
    50                  55                  60                  


Ser Arg Val Asp Ala Ala Glu Trp Ala Ala Cys Ala Gly Tyr Ala Arg 
65                  70                  75                  80  


Asp Leu Leu Cys Gln Glu Cys Ser Pro Tyr Ala Ala His Leu Tyr Asp 
                85                  90                  95      


Ala Glu Asp Pro Phe Thr Pro Leu Arg Thr Val Pro Gly Leu Cys Gln 
            100                 105                 110         


Asp Tyr Cys Leu Asp Met Trp His Lys Cys Arg Gly Leu Phe Arg His 
        115                 120                 125             


Leu Ser Thr Asp Gln Glu Leu Trp Ala Leu Glu Gly Asn Leu Ala Arg 
    130                 135                 140                 


Phe Cys Arg Tyr Leu Ser Leu Asp Asp Thr Asp Tyr Cys Phe Pro Tyr 
145                 150                 155                 160 


Leu Leu Val Asn Lys Asn Leu Asn Ser Asn Leu Gly His Val Val Ala 
                165                 170                 175     


Asp Ala Lys Gly Cys Leu Gln Leu Cys Leu Glu Glu Val Ala Asn Gly 
            180                 185                 190         


Leu Arg Asn Pro Val Ala Met Val His Ala Arg Asp Gly Thr His Arg 
        195                 200                 205             


Phe Phe Val Ala Glu Gln Val Gly Leu Val Trp Ala Tyr Leu Pro Asp 
    210                 215                 220                 


Arg Ser Arg Leu Gly Lys Pro Phe Leu Asn Ile Ser Arg Val Val Leu 
225                 230                 235                 240 


Thr Ser Pro Trp Glu Gly Asp Glu Arg Gly Phe Leu Gly Ile Ala Phe 
                245                 250                 255     


His Pro Ser Phe Gln His Asn Arg Arg Leu Tyr Val Tyr Tyr Ser Val 
            260                 265                 270         


Gly Ile Arg Ser Ser Glu Trp Ile Arg Ile Ser Glu Phe Arg Val Ser 
        275                 280                 285             


Glu Asp Asp Glu Asn Ala Val Asp His Ser Ser Glu Arg Ile Ile Leu 
    290                 295                 300                 


Glu Val Lys Glu Pro Ala Ser Asn His Asn Gly Gly Gln Leu Leu Phe 
305                 310                 315                 320 


Gly Asp Asp Gly Tyr Leu Tyr Ile Phe Thr Gly Asp Gly Gly Met Ala 
                325                 330                 335     


Gly Asp Pro Phe Gly Thr Phe Gly Asn Ala Gln Asn Lys Ser Ala Leu 
            340                 345                 350         


Leu Gly Lys Val Leu Arg Ile Asp Val Asp Arg Lys Glu Arg Gly Leu 
        355                 360                 365             


Pro Tyr Gly Ile Pro Pro Asp Asn Pro Phe Val Gly Asp Pro Ala Ala 
    370                 375                 380                 


Gln Pro Glu Val Tyr Ala Leu Gly Val Arg Asn Met Trp Arg Cys Ser 
385                 390                 395                 400 


Phe Asp Arg Gly Asp Pro Ser Ser Gly Thr Gly Arg Gly Arg Leu Phe 
                405                 410                 415     


Cys Gly Asp Val Gly Gln Asn Lys Phe Glu Glu Val Asp Val Val Glu 
            420                 425                 430         


Arg Gly Gly Asn Tyr Gly Trp Arg Ala Arg Glu Gly Phe Glu Cys Tyr 
        435                 440                 445             


Asp Arg Ser Leu Cys Ala Asn Thr Ser Leu Asn Asp Leu Leu Pro Ile 
    450                 455                 460                 


Phe Ala Tyr Pro His Thr Val Gly Lys Ser Val Thr Gly Gly Tyr Val 
465                 470                 475                 480 


Tyr Arg Gly Cys Glu Tyr Pro Asn Leu Asn Gly Leu Tyr Ile Phe Gly 
                485                 490                 495     


Asp Phe Met Ser Gly Arg Leu Met Ser Leu Gln Glu Asn Pro Gly Thr 
            500                 505                 510         


Gly Gln Trp Gln Tyr Ser Glu Ile Cys Met Gly His Gly Gln Thr Cys 
        515                 520                 525             


Glu Phe Pro Gly Leu Ile Asn Asn Tyr Tyr Pro Tyr Ile Ile Ser Phe 
    530                 535                 540                 


Gly Glu Asp Glu Ala Gly Glu Leu Tyr Phe Met Ser Thr Gly Glu Pro 
545                 550                 555                 560 


Ser Ala Thr Ala Pro Arg Gly Val Val Tyr Lys Ile Ile Asp Ala Ser 
                565                 570                 575     


Arg Arg Ala Pro Pro Gly Lys Cys Gln Ile Gln Pro Ala Gln Val Lys 
            580                 585                 590         


Ile Arg Ser Arg Leu Ile Pro Phe Val Pro Lys Glu Lys Phe Ile Pro 
        595                 600                 605             


Lys Thr Arg Ser Thr Pro Arg Pro Thr Ala Arg Ala Pro Thr Arg Ala 
    610                 615                 620                 


Pro Arg Arg Gly Arg Pro Thr Ala Ala Pro Pro Ala Pro Thr Pro Arg 
625                 630                 635                 640 


Pro Ala Arg Pro Thr Gln Gln Pro Gly Ser Arg Arg Gly Gly Gly Arg 
                645                 650                 655     


Arg Arg Gly Arg Leu Asn Ser Ala Ser Arg Ala Phe Arg Asp Gly Glu 
            660                 665                 670         


Val Arg Leu Val Arg Pro Ala Gly Leu Ser Ser Gly Ser Gly Arg Val 
        675                 680                 685             


Glu Val Phe Val Gly Gly Arg Trp Gly Thr Val Cys Asp Asp Ser Trp 
    690                 695                 700                 


Asn Ile Ser Gly Ala Ala Val Val Cys Arg Gln Leu Gly Phe Ala Tyr 
705                 710                 715                 720 


Ala Val Arg Ala Val Lys Arg Ala Glu Phe Gly Gln Gly Gly Ser Leu 
                725                 730                 735     


Pro Ile Leu Leu Asp Asp Val Arg Cys Ala Gly Trp Glu Arg Asn Leu 
            740                 745                 750         


Leu Glu Cys Gln His Asn Gly Val Gly Thr His Asn Cys Glu His Asp 
        755                 760                 765             


Glu Asp Ala Gly Val Val Cys Ser His Gln Asn Pro Asp Leu 
    770                 775                 780         


<210>  6468
<211>  608
<212>  PRT
<213>  Homo Sapiens

<400>  6468

Met Ala Arg Ala Arg Ala Gly Ala Leu Leu Ala Leu Trp Val Leu Gly 
1               5                   10                  15      


Ala Ala Ala His Pro Gln Cys Leu Asp Phe Arg Pro Pro Phe Arg Pro 
            20                  25                  30          


Thr Gln Pro Leu Arg Leu Cys Ala Gln Tyr Ser Asp Phe Gly Cys Cys 
        35                  40                  45              


Asp Glu Gly Arg Asp Ala Glu Leu Thr Arg Arg Phe Trp Ala Leu Ala 
    50                  55                  60                  


Ser Arg Val Asp Ala Ala Glu Trp Ala Ala Cys Ala Gly Tyr Ala Arg 
65                  70                  75                  80  


Asp Leu Leu Cys Gln Glu Cys Ser Pro Tyr Ala Ala His Leu Tyr Asp 
                85                  90                  95      


Ala Glu Asp Pro Phe Thr Pro Leu Arg Thr Val Pro Gly Leu Cys Gln 
            100                 105                 110         


Asp Tyr Cys Leu Asp Met Trp His Lys Cys Arg Gly Leu Phe Arg His 
        115                 120                 125             


Leu Ser Thr Asp Gln Glu Leu Trp Ala Leu Glu Gly Asn Leu Ala Arg 
    130                 135                 140                 


Phe Cys Arg Tyr Leu Ser Leu Asp Asp Thr Asp Tyr Cys Phe Pro Tyr 
145                 150                 155                 160 


Leu Leu Val Asn Lys Asn Leu Asn Ser Asn Leu Gly His Val Val Ala 
                165                 170                 175     


Asp Ala Lys Gly Cys Leu Gln Leu Cys Leu Glu Glu Val Ala Asn Gly 
            180                 185                 190         


Leu Arg Asn Pro Val Ala Met Val His Ala Arg Asp Gly Thr His Arg 
        195                 200                 205             


Phe Phe Val Ala Glu Gln Val Gly Leu Val Trp Ala Tyr Leu Pro Asp 
    210                 215                 220                 


Arg Ser Arg Leu Gly Lys Pro Phe Leu Asn Ile Ser Arg Val Val Leu 
225                 230                 235                 240 


Thr Ser Pro Trp Glu Gly Asp Glu Arg Gly Phe Leu Gly Ile Ala Phe 
                245                 250                 255     


His Pro Ser Phe Gln His Asn Arg Arg Leu Tyr Val Tyr Tyr Ser Val 
            260                 265                 270         


Gly Ile Arg Ser Ser Glu Trp Ile Arg Ile Ser Glu Phe Arg Val Ser 
        275                 280                 285             


Glu Asp Asp Glu Asn Ala Val Asp His Ser Ser Glu Arg Ile Ile Leu 
    290                 295                 300                 


Glu Val Lys Glu Pro Ala Ser Asn His Asn Gly Gly Gln Leu Leu Phe 
305                 310                 315                 320 


Gly Asp Asp Gly Tyr Leu Tyr Ile Phe Thr Gly Asp Gly Gly Met Ala 
                325                 330                 335     


Gly Asp Pro Phe Gly Thr Phe Gly Asn Ala Gln Asn Lys Ser Ala Leu 
            340                 345                 350         


Leu Gly Lys Val Leu Arg Ile Asp Val Asp Arg Lys Glu Arg Gly Leu 
        355                 360                 365             


Pro Tyr Gly Ile Pro Pro Asp Asn Pro Phe Val Gly Asp Pro Ala Ala 
    370                 375                 380                 


Gln Pro Glu Val Tyr Ala Leu Gly Val Arg Asn Met Trp Arg Cys Ser 
385                 390                 395                 400 


Phe Asp Arg Gly Asp Pro Ser Ser Gly Thr Gly Arg Gly Arg Leu Phe 
                405                 410                 415     


Cys Gly Asp Val Gly Gln Asn Lys Phe Glu Glu Val Asp Val Val Glu 
            420                 425                 430         


Arg Gly Gly Asn Tyr Gly Trp Arg Ala Arg Glu Gly Phe Glu Cys Tyr 
        435                 440                 445             


Asp Arg Ser Leu Cys Ala Asn Thr Ser Leu Asn Asp Leu Leu Pro Ile 
    450                 455                 460                 


Phe Ala Tyr Pro His Thr Val Gly Lys Ser Val Thr Gly Gly Tyr Val 
465                 470                 475                 480 


Tyr Arg Gly Cys Glu Tyr Pro Asn Leu Asn Gly Leu Tyr Ile Phe Gly 
                485                 490                 495     


Asp Phe Met Ser Gly Arg Leu Met Ser Leu Gln Glu Asn Pro Gly Thr 
            500                 505                 510         


Gly Gln Trp Gln Tyr Ser Glu Ile Cys Met Gly His Gly Gln Thr Cys 
        515                 520                 525             


Glu Phe Pro Gly Leu Ile Asn Asn Tyr Tyr Pro Tyr Ile Ile Ser Phe 
    530                 535                 540                 


Gly Glu Asp Glu Ala Gly Glu Leu Tyr Phe Met Ser Thr Gly Glu Pro 
545                 550                 555                 560 


Ser Ala Thr Ala Pro Arg Gly Val Val Tyr Lys Ile Ile Asp Ala Ser 
                565                 570                 575     


Ser Cys Lys Ala Arg Ser Ala Met Pro Gly Tyr Val Pro Ala Pro Ser 
            580                 585                 590         


Val Cys Ser Ser Leu Thr Ser Gln Pro Phe Ile Leu Gln Trp Trp Lys 
        595                 600                 605             


<210>  6469
<211>  724
<212>  PRT
<213>  Homo Sapiens

<400>  6469

Met Leu Arg Thr Ser Thr Pro Asn Leu Cys Gly Gly Leu His Cys Arg 
1               5                   10                  15      


Ala Pro Trp Leu Ser Ser Gly Ile Leu Cys Leu Cys Leu Ile Phe Leu 
            20                  25                  30          


Leu Gly Gln Val Gly Leu Leu Gln Gly His Pro Gln Cys Leu Asp Tyr 
        35                  40                  45              


Gly Pro Pro Phe Gln Pro Pro Leu His Leu Glu Phe Cys Ser Asp Tyr 
    50                  55                  60                  


Glu Ser Phe Gly Cys Cys Asp Gln His Lys Asp Arg Arg Ile Ala Ala 
65                  70                  75                  80  


Arg Tyr Trp Asp Ile Met Glu Tyr Phe Asp Leu Lys Arg His Glu Leu 
                85                  90                  95      


Cys Gly Asp Tyr Ile Lys Asp Ile Leu Cys Gln Glu Cys Ser Pro Tyr 
            100                 105                 110         


Ala Ala His Leu Tyr Asp Ala Glu Asn Thr Gln Thr Pro Leu Arg Asn 
        115                 120                 125             


Leu Pro Gly Leu Cys Ser Asp Tyr Cys Ser Ala Phe His Ser Asn Cys 
    130                 135                 140                 


His Ser Ala Ile Ser Leu Leu Thr Asn Asp Arg Gly Leu Gln Glu Ser 
145                 150                 155                 160 


His Gly Arg Asp Gly Thr Arg Phe Cys His Leu Leu Asp Leu Pro Asp 
                165                 170                 175     


Lys Asp Tyr Cys Phe Pro Asn Val Leu Arg Asn Asp Tyr Leu Asn Arg 
            180                 185                 190         


His Leu Gly Met Val Ala Gln Asp Pro Gln Gly Cys Leu Gln Leu Cys 
        195                 200                 205             


Leu Ser Glu Val Ala Asn Gly Leu Arg Asn Pro Val Ser Met Val His 
    210                 215                 220                 


Ala Gly Asp Gly Thr His Arg Phe Phe Val Ala Glu Gln Val Gly Val 
225                 230                 235                 240 


Val Trp Val Tyr Leu Pro Asp Gly Ser Arg Leu Glu Gln Pro Phe Leu 
                245                 250                 255     


Asp Leu Lys Asn Ile Val Leu Thr Thr Pro Trp Ile Gly Asp Glu Arg 
            260                 265                 270         


Gly Phe Leu Gly Leu Ala Phe His Pro Lys Phe Arg His Asn Arg Lys 
        275                 280                 285             


Phe Tyr Ile Tyr Tyr Ser Cys Leu Asp Lys Lys Lys Val Glu Lys Ile 
    290                 295                 300                 


Arg Ile Ser Glu Met Lys Val Ser Arg Ala Asp Pro Asn Lys Ala Asp 
305                 310                 315                 320 


Leu Lys Ser Glu Arg Val Ile Leu Glu Ile Glu Glu Pro Ala Ser Asn 
                325                 330                 335     


His Asn Gly Gly Gln Leu Leu Phe Gly Leu Asp Gly Tyr Met Tyr Ile 
            340                 345                 350         


Phe Thr Gly Asp Gly Gly Gln Ala Gly Asp Pro Phe Gly Leu Phe Gly 
        355                 360                 365             


Asn Ala Gln Asn Lys Ser Ser Leu Leu Gly Lys Val Leu Arg Ile Asp 
    370                 375                 380                 


Val Asn Arg Ala Gly Ser His Gly Lys Arg Tyr Arg Val Pro Ser Asp 
385                 390                 395                 400 


Asn Pro Phe Val Ser Glu Pro Gly Ala His Pro Ala Ile Tyr Ala Tyr 
                405                 410                 415     


Gly Ile Arg Asn Met Trp Arg Cys Ala Val Asp Arg Gly Asp Pro Ile 
            420                 425                 430         


Thr Arg Gln Gly Arg Gly Arg Ile Phe Cys Gly Asp Val Gly Gln Asn 
        435                 440                 445             


Arg Phe Glu Glu Val Asp Leu Ile Leu Lys Gly Gly Asn Tyr Gly Trp 
    450                 455                 460                 


Arg Ala Lys Glu Gly Phe Ala Cys Tyr Asp Lys Lys Leu Cys His Asn 
465                 470                 475                 480 


Ala Ser Leu Asp Asp Val Leu Pro Ile Tyr Ala Tyr Gly His Ala Val 
                485                 490                 495     


Gly Lys Ser Val Thr Gly Gly Tyr Val Tyr Arg Gly Cys Glu Ser Pro 
            500                 505                 510         


Asn Leu Asn Gly Leu Tyr Ile Phe Gly Asp Phe Met Ser Gly Arg Leu 
        515                 520                 525             


Met Ala Leu Gln Glu Asp Arg Lys Asn Lys Lys Trp Lys Lys Gln Asp 
    530                 535                 540                 


Leu Cys Leu Gly Ser Thr Thr Ser Cys Ala Phe Pro Gly Leu Ile Ser 
545                 550                 555                 560 


Thr His Ser Lys Phe Ile Ile Ser Phe Ala Glu Asp Glu Ala Gly Glu 
                565                 570                 575     


Leu Tyr Phe Leu Ala Thr Ser Tyr Pro Ser Ala Tyr Ala Pro Arg Gly 
            580                 585                 590         


Ser Ile Tyr Lys Phe Val Asp Pro Ser Arg Arg Ala Pro Pro Gly Lys 
        595                 600                 605             


Cys Lys Tyr Lys Pro Val Pro Val Arg Thr Lys Ser Lys Arg Ile Pro 
    610                 615                 620                 


Phe Arg Pro Leu Ala Lys Thr Val Leu Asp Leu Leu Lys Glu Gln Ser 
625                 630                 635                 640 


Glu Lys Ala Ala Arg Lys Ser Ser Ser Ala Thr Leu Ala Ser Gly Pro 
                645                 650                 655     


Ala Gln Gly Leu Ser Glu Lys Gly Ser Ser Lys Lys Leu Ala Ser Pro 
            660                 665                 670         


Thr Ser Ser Lys Asn Thr Leu Arg Gly Pro Gly Thr Lys Lys Lys Ala 
        675                 680                 685             


Arg Val Gly Pro His Val Arg Gln Gly Lys Arg Arg Lys Ser Leu Lys 
    690                 695                 700                 


Ser His Ser Gly Arg Met Arg Pro Ser Ala Glu Gln Lys Arg Ala Gly 
705                 710                 715                 720 


Arg Ser Leu Pro 
                


<210>  6470
<211>  543
<212>  PRT
<213>  Homo Sapiens

<400>  6470

Met Leu Gly Phe Leu Ser Arg Gly Pro Ser Met Lys Leu Cys Met Gly 
1               5                   10                  15      


Leu Ala Cys Val Leu Ser Leu Trp Asn Thr Val Ser Gly Ile Lys Gly 
            20                  25                  30          


Glu Ala Lys Lys Glu Lys Gly Met Thr Phe Leu Pro Thr Thr Gly Lys 
        35                  40                  45              


Trp Val Ile Arg Ala Pro Phe Gln Leu Thr Cys Leu Glu Ile Lys Met 
    50                  55                  60                  


Leu Arg Arg Lys Lys Met Gly His Ser Arg Ala Ala Leu Asn Pro Asp 
65                  70                  75                  80  


Leu Leu Leu Ser Gly Leu Arg Glu Glu Glu Arg Lys Glu Lys Gly Val 
                85                  90                  95      


Ala Phe Leu Ala Thr Thr Glu Leu Pro Ala Arg Ser Ile Asp Leu Ser 
            100                 105                 110         


Ala Leu Asn Leu Thr Glu Leu Val Asn Gly Met Leu Ser Arg Ala Leu 
        115                 120                 125             


Lys Asp Ser Lys Lys Phe Phe Ser Leu Leu Ser Val Thr Ser Tyr Ser 
    130                 135                 140                 


Ser Phe Ala Phe His Lys Phe Ser Val Ala Val Tyr Asn Ile Ser Asn 
145                 150                 155                 160 


Leu Lys Thr Val Asp Pro Ala Lys Phe Pro Thr Arg Tyr Cys Tyr Cys 
                165                 170                 175     


Leu Asn Asn Arg Thr Asn Asp Leu Ser Asp Phe Thr Ala Leu Leu Val 
            180                 185                 190         


Asp Ile Ile Gly Asn Ser Thr Ser Tyr Leu Thr Glu Ile Phe Lys Ser 
        195                 200                 205             


Thr Ser Ile Leu Ser Val Asn Gln Ser Asn Glu Ser Asp Cys Ile Phe 
    210                 215                 220                 


Ile Cys Val Met Thr Gly Lys Ser Gly Arg Asn Leu Ser Asp Phe Trp 
225                 230                 235                 240 


Glu Ile Glu Glu Lys Tyr Pro Ile Ile Asn Tyr Thr Phe Thr Ser Gly 
                245                 250                 255     


Leu Ser Gly Val Leu Gly Ala Ala Thr Arg Gly Thr Ala Arg Thr Ser 
            260                 265                 270         


Lys Pro Thr Thr Lys Ser Gln Lys Thr Leu Pro Ser Thr Ser Pro Gly 
        275                 280                 285             


His Trp Thr Gln Ser Thr Pro Trp Ala Ser Ala Leu Arg Ser Ser Pro 
    290                 295                 300                 


Trp Thr Glu Thr Ala Ala Pro Ser Glu Thr Glu Glu Thr Leu Asn Thr 
305                 310                 315                 320 


Gly Arg Pro Pro Glu Leu Pro Ala Arg Ala Thr Ala Thr Trp Phe Ser 
                325                 330                 335     


Ala Ser His Thr Leu Pro Ala Leu Ala Thr Arg Arg Val Ala Arg Thr 
            340                 345                 350         


Gln Trp Leu Thr Ala Asp Arg Gln Thr Trp Ala Ser Ile Ser Ser Val 
        355                 360                 365             


Pro Trp Ala Gln Thr Ile Ser Glu Lys Lys Pro Gly Gly Ser Leu Trp 
    370                 375                 380                 


Glu Thr Arg Ser Ser Pro Pro Thr Thr Ala Gly Thr Glu Glu Ala Met 
385                 390                 395                 400 


Asn Thr Thr Ser Leu Leu Ala Pro Ala Ala Glu Ile Met Ala Thr Pro 
                405                 410                 415     


Gly Ser Pro Ser Gln Ala Ser Pro Thr Leu Gly Ala Phe Thr His Gly 
            420                 425                 430         


Thr Gln Thr Pro Ser Pro Thr Lys Ala Thr Ala Pro Arg Tyr Pro Gln 
        435                 440                 445             


Thr Gly Asp Leu Ser Ala Glu Trp Pro Phe Thr Ala Gly Glu Glu Pro 
    450                 455                 460                 


Val Leu Val Pro Arg Pro His Gln Val Ser Arg Cys Pro Gln Pro Leu 
465                 470                 475                 480 


Phe Lys Val Gly Ala Met Ala Ala Ala Pro Leu Thr Leu Ala Ile Gln 
                485                 490                 495     


Arg Leu Asn Pro Cys Leu Met Glu Leu Cys Gln Phe Phe Gln Gln Cys 
            500                 505                 510         


Leu Cys Met Ser Gln Arg Ser Pro Arg Thr Glu Asp Met Ser Ser Phe 
        515                 520                 525             


Ile Asn Pro Tyr Gln Ser Ser Thr Ser Lys Ile Ser Trp Lys Thr 
    530                 535                 540             


<210>  6471
<211>  531
<212>  PRT
<213>  Homo Sapiens

<400>  6471

Met Leu Gly Phe Leu Ser Arg Gly Pro Ser Met Lys Leu Cys Met Gly 
1               5                   10                  15      


Leu Ala Cys Val Leu Ser Leu Trp Asn Thr Val Ser Gly Ile Lys Gly 
            20                  25                  30          


Glu Ala Lys Lys Glu Lys Gly Met Thr Phe Leu Pro Thr Thr Val Ser 
        35                  40                  45              


Gly Leu Arg Glu Glu Glu Arg Lys Glu Lys Gly Val Ala Phe Leu Ala 
    50                  55                  60                  


Thr Thr Glu Leu Pro Ala Arg Ser Ile Asp Leu Ser Ala Leu Asn Leu 
65                  70                  75                  80  


Thr Glu Leu Val Asn Gly Met Leu Ser Arg Ala Leu Lys Asp Ser Lys 
                85                  90                  95      


Lys Phe Phe Ser Leu Leu Ser Val Thr Ser Tyr Ser Ser Phe Ala Phe 
            100                 105                 110         


His Lys Phe Ser Val Ala Val Tyr Asn Ile Ser Asn Leu Lys Thr Val 
        115                 120                 125             


Asp Pro Ala Lys Phe Pro Thr Arg Tyr Cys Tyr Cys Leu Asn Asn Arg 
    130                 135                 140                 


Thr Asn Asp Leu Ser Asp Phe Thr Ala Leu Leu Val Asp Ile Ile Gly 
145                 150                 155                 160 


Asn Ser Thr Ser Tyr Leu Thr Glu Ile Phe Lys Ser Thr Ser Ile Leu 
                165                 170                 175     


Ser Val Asn Gln Ser Asn Glu Ser Asp Cys Ile Phe Ile Cys Val Met 
            180                 185                 190         


Thr Gly Lys Ser Gly Arg Asn Leu Ser Asp Phe Trp Glu Ile Glu Glu 
        195                 200                 205             


Lys Tyr Pro Ile Ile Asn Tyr Thr Phe Thr Ser Gly Leu Ser Gly Val 
    210                 215                 220                 


Leu Gly Ala Ala Thr Arg Gly Thr Ala Arg Thr Ser Lys Pro Thr Thr 
225                 230                 235                 240 


Lys Ser Gln Lys Thr Leu Pro Ser Thr Ser Pro Gly His Trp Thr Gln 
                245                 250                 255     


Ser Thr Pro Trp Ala Ser Ala Leu Arg Ser Ser Pro Trp Thr Glu Thr 
            260                 265                 270         


Ala Ala Pro Ser Glu Thr Glu Glu Thr Leu Asn Thr Gly Arg Pro Pro 
        275                 280                 285             


Glu Leu Pro Ala Arg Ala Thr Ala Thr Trp Phe Ser Ala Ser His Thr 
    290                 295                 300                 


Leu Pro Ala Leu Ala Thr Arg Arg Val Ala Arg Thr Gln Trp Leu Thr 
305                 310                 315                 320 


Ala Asp Arg Gln Thr Trp Ala Ser Ile Ser Ser Val Pro Trp Ala Gln 
                325                 330                 335     


Thr Ile Ser Glu Lys Lys Pro Gly Gly Ser Leu Trp Glu Thr Arg Ser 
            340                 345                 350         


Ser Pro Pro Thr Thr Ala Gly Thr Glu Glu Ala Met Asn Thr Thr Ser 
        355                 360                 365             


Leu Leu Ala Pro Ala Ala Glu Ile Met Ala Thr Pro Gly Ser Pro Ser 
    370                 375                 380                 


Gln Ala Ser Pro Thr Leu Gly Ala Phe Thr His Gly Thr Gln Thr Pro 
385                 390                 395                 400 


Ser Pro Thr Lys Ala Thr Ala Pro Arg Tyr Pro Gln Thr Gly Asp Leu 
                405                 410                 415     


Ser Ala Glu Trp Pro Phe Thr Ala Gly Glu Glu Pro Val Leu Val Pro 
            420                 425                 430         


Arg Pro His Gln Val Ser Arg Cys Pro Gln Pro Leu Phe Lys Val Gly 
        435                 440                 445             


Ala Met Ala Ala Ala Pro Leu Thr Leu Ala Ile Gln Arg Leu Asn Pro 
    450                 455                 460                 


Cys Leu Met Glu Leu Cys Gln Phe Phe Gln Gln Cys Leu Cys Met Ser 
465                 470                 475                 480 


Gln Arg Ser Pro Arg Thr Glu Asp Met Arg Tyr Cys Leu Glu Tyr Tyr 
                485                 490                 495     


Ser Trp Phe Leu Lys Asn Ala Thr Tyr Ile Cys Gln Arg Val Lys Arg 
            500                 505                 510         


Val Ser His Ser His Thr Leu Lys Gln Lys Cys Leu Glu Asn Ile Cys 
        515                 520                 525             


Lys Ser Val 
    530     


<210>  6472
<211>  97
<212>  PRT
<213>  Homo Sapiens

<400>  6472

Met Lys Ala Gln Thr Ala Leu Ser Phe Phe Leu Ile Leu Ile Thr Ser 
1               5                   10                  15      


Leu Ser Gly Ser Gln Gly Ile Phe Pro Leu Ala Phe Phe Ile Tyr Val 
            20                  25                  30          


Pro Met Asn Glu Gln Ile Val Ile Gly Arg Leu Asp Glu Asp Ile Ile 
        35                  40                  45              


Leu Pro Ser Ser Phe Glu Arg Gly Ser Glu Val Val Ile His Trp Lys 
    50                  55                  60                  


Tyr Gln Asp Ser Tyr Lys Val His Ser Tyr Tyr Lys Gly Ser Asp His 
65                  70                  75                  80  


Leu Glu Ser Gln Asp Pro Arg Tyr Ala Asn Arg Thr Ser Leu Phe Tyr 
                85                  90                  95      


Asn 
    


<210>  6473
<211>  136
<212>  PRT
<213>  Homo Sapiens

<400>  6473

Met Lys Ala Gln Thr Ala Leu Ser Phe Phe Leu Ile Leu Ile Thr Ser 
1               5                   10                  15      


Leu Ser Gly Ser Gln Gly Ile Phe Pro Leu Ala Phe Phe Ile Tyr Val 
            20                  25                  30          


Pro Met Asn Glu Gln Ile Val Ile Gly Arg Leu Asp Glu Asp Ile Ile 
        35                  40                  45              


Leu Pro Ser Ser Phe Glu Arg Gly Ser Glu Val Val Ile His Trp Lys 
    50                  55                  60                  


Tyr Gln Asp Ser Tyr Lys Val His Ser Tyr Tyr Lys Gly Ser Asp His 
65                  70                  75                  80  


Leu Glu Ser Gln Asp Pro Arg Tyr Ala Asn Arg Thr Ser Leu Phe Tyr 
                85                  90                  95      


Asn Glu Ile Gln Asn Gly Asn Ala Ser Leu Phe Phe Arg Arg Val Ser 
            100                 105                 110         


Leu Leu Asp Glu Gly Ile Tyr Thr Cys Tyr Val Gly Thr Ala Ile Gln 
        115                 120                 125             


Val Ile Thr Asn Lys Val Val Leu 
    130                 135     


<210>  6474
<211>  145
<212>  PRT
<213>  Homo Sapiens

<400>  6474

Met Lys Ala Gln Thr Ala Leu Ser Phe Phe Leu Ile Leu Ile Thr Ser 
1               5                   10                  15      


Leu Ser Gly Ser Gln Gly Ile Phe Pro Leu Ala Phe Phe Ile Tyr Val 
            20                  25                  30          


Pro Met Asn Glu Gln Ile Val Ile Gly Arg Leu Asp Glu Asp Ile Ile 
        35                  40                  45              


Leu Pro Ser Ser Phe Glu Arg Gly Ser Glu Val Val Ile His Trp Lys 
    50                  55                  60                  


Tyr Gln Asp Ser Tyr Lys Val His Ser Tyr Tyr Lys Gly Ser Asp His 
65                  70                  75                  80  


Leu Glu Ser Gln Asp Pro Arg Tyr Ala Asn Arg Thr Ser Leu Phe Tyr 
                85                  90                  95      


Asn Glu Ile Gln Asn Gly Asn Ala Ser Leu Phe Phe Arg Arg Val Ser 
            100                 105                 110         


Leu Leu Asp Glu Gly Ile Tyr Thr Cys Tyr Val Gly Thr Ala Ile Gln 
        115                 120                 125             


Val Ile Thr Asn Lys Val Val Leu Lys Val Gly Val Phe Leu Thr Pro 
    130                 135                 140                 


Val 
145 


<210>  6475
<211>  414
<212>  PRT
<213>  Homo Sapiens

<400>  6475

Met Lys Ala Gln Thr Ala Leu Ser Phe Phe Leu Ile Leu Ile Thr Ser 
1               5                   10                  15      


Leu Ser Gly Ser Gln Gly Ile Phe Pro Leu Ala Phe Phe Ile Tyr Val 
            20                  25                  30          


Pro Met Asn Glu Gln Ile Val Ile Gly Arg Leu Asp Glu Asp Ile Ile 
        35                  40                  45              


Leu Pro Ser Ser Phe Glu Arg Gly Ser Glu Val Val Ile His Trp Lys 
    50                  55                  60                  


Tyr Gln Asp Ser Tyr Lys Val His Ser Tyr Tyr Lys Gly Ser Asp His 
65                  70                  75                  80  


Leu Glu Ser Gln Asp Pro Arg Tyr Ala Asn Arg Thr Ser Leu Phe Tyr 
                85                  90                  95      


Asn Glu Ile Gln Asn Gly Asn Ala Ser Leu Phe Phe Arg Arg Val Ser 
            100                 105                 110         


Leu Leu Asp Glu Gly Ile Tyr Thr Cys Tyr Val Gly Thr Ala Ile Gln 
        115                 120                 125             


Val Ile Thr Asn Lys Val Val Leu Lys Val Gly Val Phe Leu Thr Pro 
    130                 135                 140                 


Val Met Lys Tyr Glu Lys Arg Asn Thr Asn Ser Phe Leu Ile Cys Ser 
145                 150                 155                 160 


Val Leu Ser Val Tyr Pro Arg Pro Ile Ile Thr Trp Lys Met Asp Asn 
                165                 170                 175     


Thr Pro Ile Ser Glu Asn Asn Met Glu Glu Thr Gly Ser Leu Asp Ser 
            180                 185                 190         


Phe Ser Ile Asn Ser Pro Leu Asn Ile Thr Gly Ser Asn Ser Ser Tyr 
        195                 200                 205             


Glu Cys Thr Ile Glu Asn Ser Leu Leu Lys Gln Thr Trp Thr Gly Arg 
    210                 215                 220                 


Trp Thr Met Lys Asp Gly Leu His Lys Met Gln Ser Glu His Val Ser 
225                 230                 235                 240 


Leu Ser Cys Gln Pro Val Asn Asp Tyr Phe Ser Pro Asn Gln Asp Phe 
                245                 250                 255     


Lys Val Thr Trp Ser Arg Met Lys Ser Gly Thr Phe Ser Val Leu Ala 
            260                 265                 270         


Tyr Tyr Leu Ser Ser Ser Gln Asn Thr Ile Ile Asn Glu Ser Arg Phe 
        275                 280                 285             


Ser Trp Asn Lys Glu Leu Ile Asn Gln Ser Asp Phe Ser Met Asn Leu 
    290                 295                 300                 


Met Asp Leu Asn Leu Ser Asp Ser Gly Glu Tyr Leu Cys Asn Ile Ser 
305                 310                 315                 320 


Ser Asp Glu Tyr Thr Leu Leu Thr Ile His Thr Val His Val Glu Pro 
                325                 330                 335     


Ser Gln Glu Thr Ala Ser His Asn Lys Gly Leu Trp Ile Leu Val Pro 
            340                 345                 350         


Ser Ala Ile Leu Ala Ala Phe Leu Leu Ile Trp Ser Val Lys Cys Cys 
        355                 360                 365             


Arg Ala Gln Leu Glu Ala Arg Arg Ser Arg His Pro Ala Asp Gly Ala 
    370                 375                 380                 


Gln Gln Glu Arg Cys Cys Val Pro Pro Gly Glu Arg Cys Pro Ser Ala 
385                 390                 395                 400 


Pro Asp Asn Gly Glu Glu Asn Val Pro Leu Ser Gly Lys Val 
                405                 410                 


<210>  6476
<211>  414
<212>  PRT
<213>  Homo Sapiens

<400>  6476

Met Lys Ala Gln Thr Ala Leu Ser Phe Phe Leu Ile Leu Ile Thr Ser 
1               5                   10                  15      


Leu Ser Gly Ser Gln Gly Ile Phe Pro Leu Ala Phe Phe Ile Tyr Val 
            20                  25                  30          


Pro Met Asn Glu Gln Ile Val Ile Gly Arg Leu Asp Glu Asp Ile Ile 
        35                  40                  45              


Leu Pro Ser Ser Phe Glu Arg Gly Ser Glu Val Val Ile His Trp Lys 
    50                  55                  60                  


Tyr Gln Asp Ser Tyr Lys Val His Ser Tyr Tyr Lys Gly Ser Asp His 
65                  70                  75                  80  


Leu Glu Ser Gln Asp Pro Arg Tyr Ala Asn Arg Thr Ser Leu Phe Tyr 
                85                  90                  95      


Asn Glu Ile Gln Asn Gly Asn Ala Ser Leu Phe Phe Arg Arg Val Ser 
            100                 105                 110         


Leu Leu Asp Glu Gly Ile Tyr Thr Cys Tyr Val Gly Thr Ala Ile Gln 
        115                 120                 125             


Val Ile Thr Asn Lys Val Val Leu Lys Val Gly Val Phe Leu Thr Pro 
    130                 135                 140                 


Val Met Lys Tyr Glu Lys Arg Asn Thr Asn Ser Phe Leu Ile Cys Ser 
145                 150                 155                 160 


Val Leu Ser Val Tyr Pro Arg Pro Ile Ile Thr Trp Lys Met Asp Asn 
                165                 170                 175     


Thr Pro Ile Ser Glu Asn Asn Met Glu Glu Thr Gly Ser Leu Asp Ser 
            180                 185                 190         


Phe Ser Ile Asn Ser Pro Leu Asn Ile Thr Gly Ser Asn Ser Ser Tyr 
        195                 200                 205             


Glu Cys Thr Ile Glu Asn Ser Leu Leu Lys Gln Thr Trp Thr Gly Arg 
    210                 215                 220                 


Trp Thr Met Lys Asp Gly Leu His Lys Met Gln Ser Glu His Val Ser 
225                 230                 235                 240 


Leu Ser Cys Gln Pro Val Asn Asp Tyr Phe Ser Pro Asn Gln Asp Phe 
                245                 250                 255     


Lys Val Thr Trp Ser Arg Met Lys Ser Gly Thr Phe Ser Val Leu Ala 
            260                 265                 270         


Tyr Tyr Leu Ser Ser Ser Gln Asn Thr Ile Ile Asn Glu Ser Arg Phe 
        275                 280                 285             


Ser Trp Asn Lys Glu Leu Ile Asn Gln Ser Asp Phe Ser Met Asn Leu 
    290                 295                 300                 


Met Asp Leu Asn Leu Ser Asp Ser Gly Glu Tyr Leu Cys Asn Ile Ser 
305                 310                 315                 320 


Ser Asp Glu Tyr Thr Leu Leu Thr Ile His Thr Val His Val Glu Pro 
                325                 330                 335     


Ser Gln Glu Thr Ala Ser His Asn Lys Gly Leu Trp Ile Leu Val Pro 
            340                 345                 350         


Ser Ala Ile Leu Ala Ala Phe Leu Leu Ile Trp Ser Val Lys Cys Cys 
        355                 360                 365             


Arg Ala Gln Leu Glu Ala Arg Arg Ser Arg His Pro Ala Asp Gly Ala 
    370                 375                 380                 


Gln Gln Glu Arg Cys Cys Val Pro Pro Gly Glu Arg Cys Pro Ser Ala 
385                 390                 395                 400 


Pro Asp Asn Gly Glu Glu Asn Val Pro Leu Ser Gly Lys Val 
                405                 410                 


<210>  6477
<211>  397
<212>  PRT
<213>  Homo Sapiens

<400>  6477

Met Lys Ala Gln Thr Ala Leu Ser Phe Phe Leu Ile Leu Ile Thr Ser 
1               5                   10                  15      


Leu Ser Gly Ser Gln Gly Ile Phe Pro Leu Ala Phe Phe Ile Tyr Val 
            20                  25                  30          


Pro Met Asn Glu Gln Ile Val Ile Gly Arg Leu Asp Glu Asp Ile Ile 
        35                  40                  45              


Leu Pro Ser Ser Phe Glu Arg Gly Ser Glu Val Val Ile His Trp Lys 
    50                  55                  60                  


Tyr Gln Asp Ser Tyr Lys Val His Ser Tyr Tyr Lys Gly Ser Asp His 
65                  70                  75                  80  


Leu Glu Ser Gln Asp Pro Arg Tyr Ala Asn Arg Thr Ser Leu Phe Tyr 
                85                  90                  95      


Asn Glu Ile Gln Asn Gly Asn Ala Ser Leu Phe Phe Arg Arg Val Ser 
            100                 105                 110         


Leu Leu Asp Glu Gly Ile Tyr Thr Cys Tyr Val Gly Thr Ala Ile Gln 
        115                 120                 125             


Val Ile Thr Asn Lys Val Val Leu Lys Val Gly Val Phe Leu Thr Pro 
    130                 135                 140                 


Val Met Lys Tyr Glu Lys Arg Asn Thr Asn Ser Phe Leu Ile Cys Ser 
145                 150                 155                 160 


Val Leu Ser Val Tyr Pro Arg Pro Ile Ile Thr Trp Lys Met Asp Asn 
                165                 170                 175     


Thr Pro Ile Ser Glu Asn Asn Met Glu Glu Thr Gly Ser Leu Asp Ser 
            180                 185                 190         


Phe Ser Ile Asn Ser Pro Leu Asn Ile Thr Gly Ser Asn Ser Ser Tyr 
        195                 200                 205             


Glu Cys Thr Ile Glu Asn Ser Leu Leu Lys Gln Thr Trp Thr Gly Arg 
    210                 215                 220                 


Trp Thr Met Lys Asp Gly Leu His Lys Met Gln Ser Glu His Val Ser 
225                 230                 235                 240 


Leu Ser Cys Gln Pro Val Asn Asp Tyr Phe Ser Pro Asn Gln Asp Phe 
                245                 250                 255     


Lys Val Thr Trp Ser Arg Met Lys Ser Gly Thr Phe Ser Val Leu Ala 
            260                 265                 270         


Tyr Tyr Leu Ser Ser Ser Gln Asn Thr Ile Ile Asn Glu Ser Arg Phe 
        275                 280                 285             


Ser Trp Asn Lys Glu Leu Ile Asn Gln Ser Asp Phe Ser Met Asn Leu 
    290                 295                 300                 


Met Asp Leu Asn Leu Ser Asp Ser Gly Glu Tyr Leu Cys Asn Ile Ser 
305                 310                 315                 320 


Ser Asp Glu Tyr Thr Leu Leu Thr Ile His Thr Val His Val Glu Pro 
                325                 330                 335     


Ser Gln Glu Thr Ala Ser His Asn Lys Gly Leu Trp Ile Leu Val Pro 
            340                 345                 350         


Ser Ala Ile Leu Ala Ala Phe Leu Leu Ile Trp Ser Val Lys Cys Cys 
        355                 360                 365             


Arg Glu Arg Cys Cys Val Pro Pro Gly Glu Arg Cys Pro Ser Ala Pro 
    370                 375                 380                 


Asp Asn Gly Glu Glu Asn Val Pro Leu Ser Gly Lys Val 
385                 390                 395         


<210>  6478
<211>  414
<212>  PRT
<213>  Homo Sapiens

<400>  6478

Met Lys Ala Gln Thr Ala Leu Ser Phe Phe Leu Ile Leu Ile Thr Ser 
1               5                   10                  15      


Leu Ser Gly Ser Gln Gly Ile Phe Pro Leu Ala Phe Phe Ile Tyr Val 
            20                  25                  30          


Pro Met Asn Glu Gln Ile Val Ile Gly Arg Leu Asp Glu Asp Ile Ile 
        35                  40                  45              


Leu Pro Ser Ser Phe Glu Arg Gly Ser Glu Val Val Ile His Trp Lys 
    50                  55                  60                  


Tyr Gln Asp Ser Tyr Lys Val His Ser Tyr Tyr Lys Gly Ser Asp His 
65                  70                  75                  80  


Leu Glu Ser Gln Asp Pro Arg Tyr Ala Asn Arg Thr Ser Leu Phe Tyr 
                85                  90                  95      


Asn Glu Ile Gln Asn Gly Asn Ala Ser Leu Phe Phe Arg Arg Val Ser 
            100                 105                 110         


Leu Leu Asp Glu Gly Ile Tyr Thr Cys Tyr Val Gly Thr Ala Ile Gln 
        115                 120                 125             


Val Ile Thr Asn Lys Val Val Leu Lys Val Gly Val Phe Leu Thr Pro 
    130                 135                 140                 


Val Met Lys Tyr Glu Lys Arg Asn Thr Asn Ser Phe Leu Ile Cys Ser 
145                 150                 155                 160 


Val Leu Ser Val Tyr Pro Arg Pro Ile Ile Thr Trp Lys Met Asp Asn 
                165                 170                 175     


Thr Pro Ile Ser Glu Asn Asn Met Glu Glu Thr Gly Ser Leu Asp Ser 
            180                 185                 190         


Phe Ser Ile Asn Ser Pro Leu Asn Ile Thr Gly Ser Asn Ser Ser Tyr 
        195                 200                 205             


Glu Cys Thr Ile Glu Asn Ser Leu Leu Lys Gln Thr Trp Thr Gly Arg 
    210                 215                 220                 


Trp Thr Met Lys Asp Gly Leu His Lys Met Gln Ser Glu His Val Ser 
225                 230                 235                 240 


Leu Ser Cys Gln Pro Val Asn Asp Tyr Phe Ser Pro Asn Gln Asp Phe 
                245                 250                 255     


Lys Val Thr Trp Ser Arg Met Lys Ser Gly Thr Phe Ser Val Leu Ala 
            260                 265                 270         


Tyr Tyr Leu Ser Ser Ser Gln Asn Thr Ile Ile Asn Glu Ser Arg Phe 
        275                 280                 285             


Ser Trp Asn Lys Glu Leu Ile Asn Gln Ser Asp Phe Ser Met Asn Leu 
    290                 295                 300                 


Met Asp Leu Asn Leu Ser Asp Ser Gly Glu Tyr Leu Cys Asn Ile Ser 
305                 310                 315                 320 


Ser Asp Glu Tyr Thr Leu Leu Thr Ile His Thr Val His Val Glu Pro 
                325                 330                 335     


Ser Gln Glu Thr Ala Ser His Asn Lys Gly Leu Trp Ile Leu Val Pro 
            340                 345                 350         


Ser Ala Ile Leu Ala Ala Phe Leu Leu Ile Trp Ser Val Lys Cys Cys 
        355                 360                 365             


Arg Ala Gln Leu Glu Ala Arg Arg Ser Arg His Pro Ala Asp Gly Ala 
    370                 375                 380                 


Gln Gln Glu Arg Cys Cys Val Pro Pro Gly Glu Arg Cys Pro Ser Ala 
385                 390                 395                 400 


Pro Asp Asn Gly Glu Glu Asn Val Pro Leu Ser Gly Lys Val 
                405                 410                 


<210>  6479
<211>  414
<212>  PRT
<213>  Homo Sapiens

<400>  6479

Met Lys Ala Gln Thr Ala Leu Ser Phe Phe Leu Ile Leu Ile Thr Ser 
1               5                   10                  15      


Leu Ser Gly Ser Gln Gly Ile Phe Pro Leu Ala Phe Phe Ile Tyr Val 
            20                  25                  30          


Pro Met Asn Glu Gln Ile Val Ile Gly Arg Leu Asp Glu Asp Ile Ile 
        35                  40                  45              


Leu Pro Ser Ser Phe Glu Arg Gly Ser Glu Val Val Ile His Trp Lys 
    50                  55                  60                  


Tyr Gln Asp Ser Tyr Lys Val His Ser Tyr Tyr Lys Gly Ser Asp His 
65                  70                  75                  80  


Leu Glu Ser Gln Asp Pro Arg Tyr Ala Asn Arg Thr Ser Leu Phe Tyr 
                85                  90                  95      


Asn Glu Ile Gln Asn Gly Asn Ala Ser Leu Phe Phe Arg Arg Val Ser 
            100                 105                 110         


Leu Leu Asp Glu Gly Ile Tyr Thr Cys Tyr Val Gly Thr Ala Ile Gln 
        115                 120                 125             


Val Ile Thr Asn Lys Val Val Leu Lys Val Gly Val Phe Leu Thr Pro 
    130                 135                 140                 


Val Met Lys Tyr Glu Lys Arg Asn Thr Asn Ser Phe Leu Ile Cys Ser 
145                 150                 155                 160 


Val Leu Ser Val Tyr Pro Arg Pro Ile Ile Thr Trp Lys Met Asp Asn 
                165                 170                 175     


Thr Pro Ile Ser Glu Asn Asn Met Glu Glu Thr Gly Ser Leu Asp Ser 
            180                 185                 190         


Phe Ser Ile Asn Ser Pro Leu Asn Ile Thr Gly Ser Asn Ser Ser Tyr 
        195                 200                 205             


Glu Cys Thr Ile Glu Asn Ser Leu Leu Lys Gln Thr Trp Thr Gly Arg 
    210                 215                 220                 


Trp Thr Met Lys Asp Gly Leu His Lys Met Gln Ser Glu His Val Ser 
225                 230                 235                 240 


Leu Ser Cys Gln Pro Val Asn Asp Tyr Phe Ser Pro Asn Gln Asp Phe 
                245                 250                 255     


Lys Val Thr Trp Ser Arg Met Lys Ser Gly Thr Phe Ser Val Leu Ala 
            260                 265                 270         


Tyr Tyr Leu Ser Ser Ser Gln Asn Thr Ile Ile Asn Glu Ser Arg Phe 
        275                 280                 285             


Ser Trp Asn Lys Glu Leu Ile Asn Gln Ser Asp Phe Ser Met Asn Leu 
    290                 295                 300                 


Met Asp Leu Asn Leu Ser Asp Ser Gly Glu Tyr Leu Cys Asn Ile Ser 
305                 310                 315                 320 


Ser Asp Glu Tyr Thr Leu Leu Thr Ile His Thr Val His Val Glu Pro 
                325                 330                 335     


Ser Gln Glu Thr Ala Ser His Asn Lys Gly Leu Trp Ile Leu Val Pro 
            340                 345                 350         


Ser Ala Ile Leu Ala Ala Phe Leu Leu Ile Trp Ser Val Lys Cys Cys 
        355                 360                 365             


Arg Ala Gln Leu Glu Ala Arg Arg Ser Arg His Pro Ala Asp Gly Ala 
    370                 375                 380                 


Gln Gln Glu Arg Cys Cys Val Pro Pro Gly Glu Arg Cys Pro Ser Ala 
385                 390                 395                 400 


Pro Asp Asn Gly Glu Glu Asn Val Pro Leu Ser Gly Lys Val 
                405                 410                 


<210>  6480
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  6480

Met Asn Glu Gln Ile Val Ile Gly Arg Leu Asp Glu Asp Ile Ile Leu 
1               5                   10                  15      


Pro Ser Ser Phe Glu Arg Gly Ser Glu Val Val Ile His Trp Lys Tyr 
            20                  25                  30          


Gln Asp Ser Tyr Lys Val His Ser Tyr Tyr Lys Gly Ser Asp His Leu 
        35                  40                  45              


Glu Ser Gln Asp Pro Arg Tyr Ala Asn Arg Thr Ser Leu Phe Tyr Asn 
    50                  55                  60                  


Glu Ile Gln Asn Gly Asn Ala Ser Leu Phe Phe Arg Arg Val Ser Leu 
65                  70                  75                  80  


Leu Asp Glu Gly Ile Tyr Thr Cys Tyr Val Gly Thr Ala Ile Gln Val 
                85                  90                  95      


Ile Thr Asn Lys Val Val Leu Lys Val Gly Val Phe Leu Thr Pro Val 
            100                 105                 110         


Met Lys Tyr Glu Lys Arg Asn Thr Asn Ser Phe Leu Ile Cys Ser Val 
        115                 120                 125             


<210>  6481
<211>  350
<212>  PRT
<213>  Homo Sapiens

<400>  6481

Met Val Met Trp Asn Ile Leu Lys Pro Arg Thr His Leu Leu Cys Met 
1               5                   10                  15      


Thr Asn Met Phe Cys Thr Arg His Glu Gly Thr Asp Ser Thr Val Phe 
            20                  25                  30          


Leu Pro His Ser His Asn Ile Ser Glu Trp Ile Ser Arg Arg Val Ser 
        35                  40                  45              


Leu Leu Asp Glu Gly Ile Tyr Thr Cys Tyr Val Gly Thr Ala Ile Gln 
    50                  55                  60                  


Val Ile Thr Asn Lys Val Val Leu Lys Val Gly Val Phe Leu Thr Pro 
65                  70                  75                  80  


Val Met Lys Tyr Glu Lys Arg Asn Thr Asn Ser Phe Leu Ile Cys Ser 
                85                  90                  95      


Val Leu Ser Val Tyr Pro Arg Pro Ile Ile Thr Trp Lys Met Asp Asn 
            100                 105                 110         


Thr Pro Ile Ser Glu Asn Asn Met Glu Glu Thr Gly Ser Leu Asp Ser 
        115                 120                 125             


Phe Ser Ile Asn Ser Pro Leu Asn Ile Thr Gly Ser Asn Ser Ser Tyr 
    130                 135                 140                 


Glu Cys Thr Ile Glu Asn Ser Leu Leu Lys Gln Thr Trp Thr Gly Arg 
145                 150                 155                 160 


Trp Thr Met Lys Asp Gly Leu His Lys Met Gln Ser Glu His Val Ser 
                165                 170                 175     


Leu Ser Cys Gln Pro Val Asn Asp Tyr Phe Ser Pro Asn Gln Asp Phe 
            180                 185                 190         


Lys Val Thr Trp Ser Arg Met Lys Ser Gly Thr Phe Ser Val Leu Ala 
        195                 200                 205             


Tyr Tyr Leu Ser Ser Ser Gln Asn Thr Ile Ile Asn Glu Ser Arg Phe 
    210                 215                 220                 


Ser Trp Asn Lys Glu Leu Ile Asn Gln Ser Asp Phe Ser Met Asn Leu 
225                 230                 235                 240 


Met Asp Leu Asn Leu Ser Asp Ser Gly Glu Tyr Leu Cys Asn Ile Ser 
                245                 250                 255     


Ser Asp Glu Tyr Thr Leu Leu Thr Ile His Thr Val His Val Glu Pro 
            260                 265                 270         


Ser Gln Glu Thr Ala Ser His Asn Lys Gly Leu Trp Ile Leu Val Pro 
        275                 280                 285             


Ser Ala Ile Leu Ala Ala Phe Leu Leu Ile Trp Ser Val Lys Cys Cys 
    290                 295                 300                 


Arg Ala Gln Leu Glu Ala Arg Arg Ser Arg His Pro Ala Asp Gly Ala 
305                 310                 315                 320 


Gln Gln Glu Arg Cys Cys Val Pro Pro Gly Glu Arg Cys Pro Ser Ala 
                325                 330                 335     


Pro Asp Asn Gly Glu Glu Asn Val Pro Leu Ser Gly Lys Val 
            340                 345                 350 


<210>  6482
<211>  328
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6482

Xaa Ile Gln Asn Gly Asn Ala Ser Leu Phe Phe Arg Arg Val Ser Leu 
1               5                   10                  15      


Leu Asp Glu Gly Ile Tyr Thr Cys Tyr Val Gly Thr Ala Ile Gln Val 
            20                  25                  30          


Ile Thr Asn Lys Val Val Leu Lys Val Gly Val Phe Leu Thr Pro Val 
        35                  40                  45              


Met Lys Tyr Glu Lys Arg Asn Thr Asn Ser Phe Leu Ile Cys Ser Val 
    50                  55                  60                  


Leu Ser Val Tyr Pro Arg Pro Ile Ile Thr Trp Lys Met Asp Asn Thr 
65                  70                  75                  80  


Pro Ile Ser Glu Asn Asn Met Glu Glu Thr Gly Ser Leu Asp Ser Phe 
                85                  90                  95      


Ser Ile Asn Ser Pro Leu Asn Ile Thr Gly Ser Asn Ser Ser Tyr Glu 
            100                 105                 110         


Cys Thr Ile Glu Asn Ser Leu Leu Lys Gln Thr Trp Thr Gly Arg Trp 
        115                 120                 125             


Thr Met Lys Asp Gly Leu His Lys Met Gln Ser Glu His Val Ser Leu 
    130                 135                 140                 


Ser Cys Gln Pro Val Asn Asp Tyr Phe Ser Pro Asn Gln Asp Phe Lys 
145                 150                 155                 160 


Val Thr Trp Ser Arg Met Lys Ser Gly Thr Phe Ser Val Leu Ala Tyr 
                165                 170                 175     


Tyr Leu Ser Ser Ser Gln Asn Thr Ile Ile Asn Glu Ser Arg Phe Ser 
            180                 185                 190         


Trp Asn Lys Glu Leu Ile Asn Gln Ser Asp Phe Ser Met Asn Leu Met 
        195                 200                 205             


Asp Leu Asn Leu Ser Asp Ser Gly Glu Tyr Leu Cys Asn Ile Ser Ser 
    210                 215                 220                 


Asp Glu Tyr Thr Leu Leu Thr Ile His Thr Val His Val Glu Pro Ser 
225                 230                 235                 240 


Gln Glu Thr Ala Ser His Asn Lys Gly Leu Trp Ile Leu Val Pro Ser 
                245                 250                 255     


Ala Ile Leu Ala Ala Phe Leu Leu Ile Trp Ser Val Lys Cys Cys Arg 
            260                 265                 270         


Ala Gln Leu Glu Ala Arg Arg Ser Arg His Pro Ala Asp Gly Ala Gln 
        275                 280                 285             


Gln Glu Arg Cys Cys Val Pro Pro Gly Glu Arg Cys Pro Ser Ala Pro 
    290                 295                 300                 


Asp Asn Gly Glu Glu Asn Val Val Arg His Tyr Phe Leu Tyr Gln Thr 
305                 310                 315                 320 


Ile Tyr Ser Ile Lys Met Leu Leu 
                325             


<210>  6483
<211>  39
<212>  PRT
<213>  Homo Sapiens

<400>  6483

Met Ala Ala Ser Leu Arg Leu Leu Gly Ala Ala Ser Gly Leu Arg Tyr 
1               5                   10                  15      


Trp Ser Arg Arg Leu Arg Pro Ala Ala Gly Ser Phe Ala Ala Gly Ser 
            20                  25                  30          


Ile Phe Pro Ser Arg Cys Cys 
        35                  


<210>  6484
<211>  336
<212>  PRT
<213>  Homo Sapiens

<400>  6484

Met Ala Ala Ser Leu Arg Leu Leu Gly Ala Ala Ser Gly Leu Arg Tyr 
1               5                   10                  15      


Trp Ser Arg Arg Leu Arg Pro Ala Ala Gly Ser Phe Ala Ala Val Cys 
            20                  25                  30          


Ser Arg Ser Val Ala Ser Lys Thr Pro Val Gly Phe Ile Gly Leu Gly 
        35                  40                  45              


Asn Met Gly Asn Pro Met Ala Lys Asn Leu Met Lys His Gly Tyr Pro 
    50                  55                  60                  


Leu Ile Ile Tyr Asp Val Phe Pro Asp Ala Cys Lys Glu Phe Gln Asp 
65                  70                  75                  80  


Ala Gly Glu Gln Val Val Ser Ser Pro Ala Asp Val Ala Glu Lys Ala 
                85                  90                  95      


Asp Arg Ile Ile Thr Met Leu Pro Thr Ser Ile Asn Ala Ile Glu Ala 
            100                 105                 110         


Tyr Ser Gly Ala Asn Gly Ile Leu Lys Lys Val Lys Lys Gly Ser Leu 
        115                 120                 125             


Leu Ile Asp Ser Ser Thr Ile Asp Pro Ala Val Ser Lys Glu Leu Ala 
    130                 135                 140                 


Lys Glu Val Glu Lys Met Gly Ala Val Phe Met Asp Ala Pro Val Ser 
145                 150                 155                 160 


Gly Gly Val Gly Ala Ala Arg Ser Gly Asn Leu Thr Phe Met Val Gly 
                165                 170                 175     


Gly Val Glu Asp Glu Phe Ala Ala Ala Gln Glu Leu Leu Gly Cys Met 
            180                 185                 190         


Gly Ser Asn Val Val Tyr Cys Gly Ala Val Gly Thr Gly Gln Ala Ala 
        195                 200                 205             


Lys Ile Cys Asn Asn Met Leu Leu Ala Ile Ser Met Ile Gly Thr Ala 
    210                 215                 220                 


Glu Ala Met Asn Leu Gly Ile Arg Leu Gly Leu Asp Pro Lys Leu Leu 
225                 230                 235                 240 


Ala Lys Ile Leu Asn Met Ser Ser Gly Arg Cys Trp Ser Ser Asp Thr 
                245                 250                 255     


Tyr Asn Pro Val Pro Gly Val Met Asp Gly Val Pro Ser Ala Asn Asn 
            260                 265                 270         


Tyr Gln Gly Gly Phe Gly Thr Thr Leu Met Ala Lys Asp Leu Gly Leu 
        275                 280                 285             


Ala Gln Asp Ser Ala Thr Ser Thr Lys Ser Pro Ile Leu Leu Gly Ser 
    290                 295                 300                 


Leu Ala His Gln Ile Tyr Arg Met Met Cys Ala Lys Gly Tyr Ser Lys 
305                 310                 315                 320 


Lys Asp Phe Ser Ser Val Phe Gln Phe Leu Arg Glu Glu Glu Thr Phe 
                325                 330                 335     


<210>  6485
<211>  206
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6485

Xaa Glu Leu Pro His Thr Leu Lys Leu Pro Gly Leu Pro Leu Phe Pro 
1               5                   10                  15      


Asn Lys Phe Leu Ile Ser Leu Val Leu Leu Ile Leu Val Ser Ser Pro 
            20                  25                  30          


Ala Asp Val Ala Glu Lys Ala Asp Arg Ile Ile Thr Met Leu Pro Thr 
        35                  40                  45              


Ser Ile Asn Ala Ile Glu Ala Tyr Ser Gly Ala Asn Gly Ile Leu Lys 
    50                  55                  60                  


Lys Val Lys Lys Gly Ser Leu Leu Ile Asp Ser Ser Thr Ile Asp Pro 
65                  70                  75                  80  


Ala Val Ser Lys Glu Leu Ala Lys Glu Val Glu Lys Met Gly Ala Val 
                85                  90                  95      


Phe Met Asp Ala Pro Val Ser Gly Gly Val Gly Ala Ala Arg Ser Gly 
            100                 105                 110         


Asn Leu Thr Phe Met Val Gly Gly Val Glu Asp Glu Phe Ala Ala Ala 
        115                 120                 125             


Gln Glu Leu Leu Gly Cys Met Gly Ser Asn Val Val Tyr Cys Gly Ala 
    130                 135                 140                 


Val Gly Thr Gly Gln Ala Ala Lys Ile Cys Asn Asn Met Leu Leu Ala 
145                 150                 155                 160 


Ile Ser Met Ile Gly Thr Ala Glu Ala Met Asn Leu Gly Ile Arg Leu 
                165                 170                 175     


Gly Leu Asp Pro Lys Leu Leu Ala Lys Ile Leu Asn Met Ser Ser Gly 
            180                 185                 190         


Arg Cys Trp Ser Ser Asp Thr Tyr Asn Pro Val Pro Gly Val 
        195                 200                 205     


<210>  6486
<211>  163
<212>  PRT
<213>  Homo Sapiens

<400>  6486

Met Ala Ala Ala Val Val Leu Ala Ala Gly Leu Arg Ala Ala Arg Arg 
1               5                   10                  15      


Ala Val Ala Ala Thr Gly Val Arg Gly Gly Gln Val Arg Gly Ala Ala 
            20                  25                  30          


Gly Val Thr Asp Gly Asn Glu Val Ala Lys Ala Gln Gln Ala Thr Pro 
        35                  40                  45              


Gly Gly Ala Ala Pro Thr Ile Phe Ser Arg Ile Leu Asp Lys Ser Leu 
    50                  55                  60                  


Pro Ala Asp Ile Leu Tyr Glu Asp Gln Gln Cys Leu Val Phe Arg Asp 
65                  70                  75                  80  


Val Ala Pro Gln Ala Pro Val His Phe Leu Val Ile Pro Lys Lys Pro 
                85                  90                  95      


Ile Pro Arg Ile Ser Gln Ala Glu Glu Glu Asp Gln Gln Leu Leu Gly 
            100                 105                 110         


His Leu Leu Leu Val Ala Lys Gln Thr Ala Lys Ala Glu Gly Leu Gly 
        115                 120                 125             


Asp Gly Tyr Arg Leu Val Ile Asn Asp Gly Lys Leu Gly Ala Gln Ser 
    130                 135                 140                 


Val Tyr His Leu His Ile His Val Leu Gly Gly Arg Gln Leu Gln Trp 
145                 150                 155                 160 


Pro Pro Gly 
            


<210>  6487
<211>  365
<212>  PRT
<213>  Homo Sapiens

<400>  6487

Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Gln Glu Thr Arg Asn Val Lys Ala Gln Ser Gln 
                85                  90                  95      


Thr Asp Arg Val Asp Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Ile Gln Ile Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Ser Asp Gly Arg Phe Leu Arg Gly Tyr Arg Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Met Ala Ala Gln Ile Thr Lys Arg Lys Trp Glu Ala Ala His Glu 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Asp Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro 
        195                 200                 205             


Pro Lys Thr His Met Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Leu Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ala 
305                 310                 315                 320 


Val Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Lys Ser 
                325                 330                 335     


Ser Asp Arg Lys Gly Gly Ser Tyr Thr Gln Ala Ala Ser Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Val 
        355                 360                 365 


<210>  6488
<211>  299
<212>  PRT
<213>  Homo Sapiens

<400>  6488

Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Gln Glu Thr Arg Asn Val Lys Ala Gln Ser Gln 
                85                  90                  95      


Thr Asp Arg Val Asp Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Ile Gln Ile Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Ser Asp Gly Arg Phe Leu Arg Gly Tyr Arg Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Met Ala Ala Gln Ile Thr Lys Arg Lys Trp Glu Ala Ala His Glu 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Asp Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro 
        195                 200                 205             


Pro Lys Thr His Met Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Val 
    290                 295                 


<210>  6489
<211>  365
<212>  PRT
<213>  Homo Sapiens

<400>  6489

Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Gln Glu Thr Arg Asn Val Lys Ala Gln Ser Gln 
                85                  90                  95      


Thr Asp Arg Val Asp Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Ile Gln Ile Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Ser Asp Gly Arg Phe Leu Arg Gly Tyr Arg Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Met Ala Ala Gln Ile Thr Lys Arg Lys Trp Glu Ala Ala His Glu 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Asp Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro 
        195                 200                 205             


Pro Lys Thr His Met Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Leu Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ala 
305                 310                 315                 320 


Val Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Lys Ser 
                325                 330                 335     


Ser Asp Arg Lys Gly Gly Ser Tyr Thr Gln Ala Ala Ser Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Val 
        355                 360                 365 


<210>  6490
<211>  371
<212>  PRT
<213>  Homo Sapiens

<400>  6490

Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Gln Glu Thr Arg Asn Val Lys Ala Gln Ser Gln 
                85                  90                  95      


Thr Asp Arg Val Asp Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Ile Gln Ile Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Ser Asp Gly Arg Phe Leu Arg Gly Tyr Arg Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Met Ala Ala Gln Ile Thr Lys Arg Lys Trp Glu Ala Ala His Glu 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Asp Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro 
        195                 200                 205             


Pro Lys Thr His Met Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Leu Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ala 
305                 310                 315                 320 


Val Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Lys Ser 
                325                 330                 335     


Ser Gly Gly Glu Gly Val Lys Asp Arg Lys Gly Gly Ser Tyr Thr Gln 
            340                 345                 350         


Ala Ala Ser Ser Asp Ser Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
        355                 360                 365             


Cys Lys Val 
    370     


<210>  6491
<211>  325
<212>  PRT
<213>  Homo Sapiens

<400>  6491

Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Gln Glu Thr Arg Asn Val Lys Ala Gln Ser Gln 
                85                  90                  95      


Thr Asp Arg Val Asp Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Ile Gln Ile Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Ser Asp Gly Arg Phe Leu Arg Gly Tyr Arg Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Met Ala Ala Gln Ile Thr Lys Arg Lys Trp Glu Ala Ala His Glu 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Asp Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro 
        195                 200                 205             


Pro Lys Thr His Met Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Asp Arg Lys Gly Gly Ser 
    290                 295                 300                 


Tyr Thr Gln Ala Ala Ser Ser Asp Ser Ala Gln Gly Ser Asp Val Ser 
305                 310                 315                 320 


Leu Thr Ala Cys Lys 
                325 


<210>  6492
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  6492

Met Arg Val Met Ala Pro Arg Ala Leu Leu Leu Leu Leu Ser Gly Gly 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Cys Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Asp Thr Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Gly Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Lys Tyr Lys Arg Gln Ala Gln 
                85                  90                  95      


Ala Asp Arg Val Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Asp Glu Asp Val Trp Leu Arg Pro Gly Ala Arg Arg Ala Pro Pro 
        115                 120                 125             


Pro Arg Val 
    130     


<210>  6493
<211>  366
<212>  PRT
<213>  Homo Sapiens

<400>  6493

Met Arg Val Met Ala Pro Arg Ala Leu Leu Leu Leu Leu Ser Gly Gly 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Cys Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Asp Thr Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Gly Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Lys Tyr Lys Arg Gln Ala Gln 
                85                  90                  95      


Ala Asp Arg Val Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Asp Gly Ser His Thr Leu Gln Arg Met Ser Gly Cys Asp Leu Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr Asp Gln Ser Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Leu Glu Ala Ala Arg Ala 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Leu Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Met Gln His Glu 
        275                 280                 285             


Gly Leu Gln Glu Pro Leu Thr Leu Ser Trp Glu Pro Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Met Gly Ile Val Ala Gly Leu Ala Val Leu Val Val 
305                 310                 315                 320 


Leu Ala Val Leu Gly Ala Val Val Thr Ala Met Met Cys Arg Arg Lys 
                325                 330                 335     


Ser Ser Gly Gly Lys Gly Gly Ser Cys Ser Gln Ala Ala Cys Ser Asn 
            340                 345                 350         


Ser Ala Gln Gly Ser Asp Glu Ser Leu Ile Thr Cys Lys Ala 
        355                 360                 365     


<210>  6494
<211>  372
<212>  PRT
<213>  Homo Sapiens

<400>  6494

Met Arg Val Met Ala Pro Arg Ala Leu Leu Leu Leu Leu Ser Gly Gly 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Cys Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Asp Thr Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Gly Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Lys Tyr Lys Arg Gln Ala Gln 
                85                  90                  95      


Ala Asp Arg Val Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Asp Gly Ser His Thr Leu Gln Arg Met Ser Gly Cys Asp Leu Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr Asp Gln Ser Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Leu Glu Ala Ala Arg Ala 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Leu Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Met Gln His Glu 
        275                 280                 285             


Gly Leu Gln Glu Pro Leu Thr Leu Ser Trp Glu Pro Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Met Gly Ile Val Ala Gly Leu Ala Val Leu Val Val 
305                 310                 315                 320 


Leu Ala Val Leu Gly Ala Val Val Thr Ala Met Met Cys Arg Arg Lys 
                325                 330                 335     


Ser Ser Gly His Phe Leu Pro Thr Gly Gly Lys Gly Gly Ser Cys Ser 
            340                 345                 350         


Gln Ala Ala Cys Ser Asn Ser Ala Gln Gly Ser Asp Glu Ser Leu Ile 
        355                 360                 365             


Thr Cys Lys Ala 
    370         


<210>  6495
<211>  244
<212>  PRT
<213>  Homo Sapiens

<400>  6495

Met Ser Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
1               5                   10                  15      


Asp Gln Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
            20                  25                  30          


Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
        35                  40                  45              


Lys Leu Glu Ala Ala Arg Ala Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
    50                  55                  60                  


Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
65                  70                  75                  80  


Thr Leu Gln Arg Ala Glu Pro Pro Lys Thr His Val Thr His His Pro 
                85                  90                  95      


Leu Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr 
            100                 105                 110         


Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr 
        115                 120                 125             


Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe 
    130                 135                 140                 


Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg Tyr 
145                 150                 155                 160 


Thr Cys His Met Gln His Glu Gly Leu Gln Glu Pro Leu Thr Leu Ser 
                165                 170                 175     


Trp Glu Pro Ser Ser Gln Pro Thr Ile Pro Ile Met Gly Ile Val Ala 
            180                 185                 190         


Gly Leu Ala Val Leu Val Val Leu Ala Val Leu Gly Ala Val Val Thr 
        195                 200                 205             


Ala Met Met Cys Arg Arg Lys Ser Ser Gly Gly Lys Gly Gly Ser Cys 
    210                 215                 220                 


Ser Gln Ala Ala Cys Ser Asn Ser Ala Gln Gly Ser Asp Glu Ser Leu 
225                 230                 235                 240 


Ile Thr Cys Lys 
                


<210>  6496
<211>  261
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6496

Xaa Arg Val Met Ala Pro Arg Ala Leu Leu Leu Leu Leu Ser Gly Gly 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Cys Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Asp Thr Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Gly Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Lys Tyr Lys Arg Gln Ala Gln 
                85                  90                  95      


Ala Asp Arg Val Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Asp Gly Ser His Thr Leu Gln Arg Met Ser Gly Cys Asp Leu Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr Asp Gln Ser Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Leu Glu Ala Ala Arg Ala 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Leu Ser Asp His Glu Ala Ser 
    210                 215                 220                 


Arg Arg Trp Asn Leu Pro Glu Val Gly Ser Cys Gly Gly Ala Phe Trp 
225                 230                 235                 240 


Thr Arg Ala Glu Ile His Val Pro Tyr Ala Ala Arg Gly Ala Ala Arg 
                245                 250                 255     


Ala Pro His Pro Glu 
            260     


<210>  6497
<211>  250
<212>  PRT
<213>  Homo Sapiens

<400>  6497

Met Ala Leu Arg Ala Gly Leu Val Leu Gly Phe His Thr Leu Met Thr 
1               5                   10                  15      


Leu Leu Ser Pro Gln Glu Ala Gly Ala Thr Lys Ala Asp His Met Gly 
            20                  25                  30          


Ser Tyr Gly Pro Ala Phe Tyr Gln Ser Tyr Gly Ala Ser Gly Gln Phe 
        35                  40                  45              


Thr His Glu Phe Asp Glu Glu Gln Leu Phe Ser Val Asp Leu Lys Lys 
    50                  55                  60                  


Ser Glu Ala Val Trp Arg Leu Pro Glu Phe Gly Asp Phe Ala Arg Phe 
65                  70                  75                  80  


Asp Pro Gln Gly Gly Leu Ala Gly Ile Ala Ala Ile Lys Ala His Leu 
                85                  90                  95      


Asp Ile Leu Val Glu Arg Ser Asn Arg Ser Arg Ala Ile Asn Val Pro 
            100                 105                 110         


Pro Arg Val Thr Val Leu Pro Lys Ser Arg Val Glu Leu Gly Gln Pro 
        115                 120                 125             


Asn Ile Leu Ile Cys Ile Val Asp Asn Ile Phe Pro Pro Val Ile Asn 
    130                 135                 140                 


Ile Thr Trp Leu Arg Asn Gly Gln Thr Val Thr Glu Gly Val Ala Gln 
145                 150                 155                 160 


Thr Ser Phe Tyr Ser Gln Pro Asp His Leu Phe Arg Lys Phe His Tyr 
                165                 170                 175     


Leu Pro Phe Val Pro Ser Ala Glu Asp Val Tyr Asp Cys Gln Val Glu 
            180                 185                 190         


His Trp Gly Leu Asp Ala Pro Leu Leu Arg His Trp Glu Leu Gln Val 
        195                 200                 205             


Pro Ile Pro Pro Pro Asp Ala Met Glu Thr Leu Val Cys Ala Leu Gly 
    210                 215                 220                 


Leu Ala Ile Gly Leu Val Gly Phe Leu Val Gly Thr Val Leu Ile Ile 
225                 230                 235                 240 


Met Gly Thr Tyr Val Ser Ser Val Pro Arg 
                245                 250 


<210>  6498
<211>  86
<212>  PRT
<213>  Homo Sapiens

<400>  6498

Met Ala Leu Arg Ala Gly Leu Val Leu Gly Phe His Thr Leu Met Thr 
1               5                   10                  15      


Leu Leu Ser Pro Gln Glu Ala Gly Ala Thr Lys Gly Arg Ala Gly Arg 
            20                  25                  30          


His Arg Arg Asn Gln Ser Pro Ser Gly His Pro Gly Gly Ala Leu Gln 
        35                  40                  45              


Pro Gln Gln Ser His Gln Arg Ala Ser Thr Gly Asp Arg Ala Pro Gln 
    50                  55                  60                  


Val Ser Gly Gly Ala Gly Pro Ala Gln His Pro His Leu His Arg Gly 
65                  70                  75                  80  


Gln His Leu Pro Pro Cys 
                85      


<210>  6499
<211>  23
<212>  PRT
<213>  Homo Sapiens

<400>  6499

Met Arg Pro Glu Asp Arg Met Phe His Ile Arg Ala Val Ile Leu Arg 
1               5                   10                  15      


Ala Leu Ser Leu Ala Phe Leu 
            20              


<210>  6500
<211>  209
<212>  PRT
<213>  Homo Sapiens

<400>  6500

Met Arg Pro Glu Asp Arg Met Phe His Ile Arg Ala Val Ile Leu Arg 
1               5                   10                  15      


Ala Leu Ser Leu Ala Phe Leu Leu Ser Leu Arg Gly Ala Gly Ala Ile 
            20                  25                  30          


Lys Ala Asp His Val Ser Thr Tyr Ala Ala Phe Val Gln Thr His Arg 
        35                  40                  45              


Pro Thr Gly Glu Phe Met Phe Glu Phe Asp Glu Asp Glu Met Phe Tyr 
    50                  55                  60                  


Val Asp Leu Asp Lys Lys Glu Thr Val Trp His Leu Glu Glu Phe Gly 
65                  70                  75                  80  


Gln Ala Phe Ser Phe Glu Ala Gln Gly Gly Leu Ala Asn Ile Ala Ile 
                85                  90                  95      


Leu Asn Asn Asn Leu Asn Thr Leu Ile Gln Arg Ser Asn His Thr Gln 
            100                 105                 110         


Ala Thr Asn Asp Pro Pro Glu Val Thr Val Phe Pro Lys Glu Pro Val 
        115                 120                 125             


Glu Leu Gly Gln Pro Asn Thr Leu Ile Cys His Ile Asp Lys Phe Phe 
    130                 135                 140                 


Pro Pro Val Leu Asn Val Thr Trp Leu Cys Asn Gly Glu Leu Val Thr 
145                 150                 155                 160 


Glu Gly Val Ala Glu Ser Leu Phe Leu Pro Arg Thr Asp Tyr Ser Phe 
                165                 170                 175     


His Lys Phe His Tyr Leu Thr Phe Val Pro Ser Ala Glu Asp Phe Tyr 
            180                 185                 190         


Asp Cys Arg Val Glu His Trp Gly Leu Asp Gln Pro Leu Leu Lys His 
        195                 200                 205             


Trp 
    


<210>  6501
<211>  260
<212>  PRT
<213>  Homo Sapiens

<400>  6501

Met Arg Pro Glu Asp Arg Met Phe His Ile Arg Ala Val Ile Leu Arg 
1               5                   10                  15      


Ala Leu Ser Leu Ala Phe Leu Leu Ser Leu Arg Gly Ala Gly Ala Ile 
            20                  25                  30          


Lys Ala Asp His Val Ser Thr Tyr Ala Ala Phe Val Gln Thr His Arg 
        35                  40                  45              


Pro Thr Gly Glu Phe Met Phe Glu Phe Asp Glu Asp Glu Met Phe Tyr 
    50                  55                  60                  


Val Asp Leu Asp Lys Lys Glu Thr Val Trp His Leu Glu Glu Phe Gly 
65                  70                  75                  80  


Gln Ala Phe Ser Phe Glu Ala Gln Gly Gly Leu Ala Asn Ile Ala Ile 
                85                  90                  95      


Leu Asn Asn Asn Leu Asn Thr Leu Ile Gln Arg Ser Asn His Thr Gln 
            100                 105                 110         


Ala Thr Asn Asp Pro Pro Glu Val Thr Val Phe Pro Lys Glu Pro Val 
        115                 120                 125             


Glu Leu Gly Gln Pro Asn Thr Leu Ile Cys His Ile Asp Lys Phe Phe 
    130                 135                 140                 


Pro Pro Val Leu Asn Val Thr Trp Leu Cys Asn Gly Glu Leu Val Thr 
145                 150                 155                 160 


Glu Gly Val Ala Glu Ser Leu Phe Leu Pro Arg Thr Asp Tyr Ser Phe 
                165                 170                 175     


His Lys Phe His Tyr Leu Thr Phe Val Pro Ser Ala Glu Asp Phe Tyr 
            180                 185                 190         


Asp Cys Arg Val Glu His Trp Gly Leu Asp Gln Pro Leu Leu Lys His 
        195                 200                 205             


Trp Glu Ala Gln Glu Pro Ile Gln Met Pro Glu Thr Thr Glu Thr Val 
    210                 215                 220                 


Leu Cys Ala Leu Gly Leu Val Leu Gly Leu Val Gly Ile Ile Val Gly 
225                 230                 235                 240 


Thr Val Leu Ile Ile Lys Ser Leu Arg Ser Gly His Asp Pro Arg Ala 
                245                 250                 255     


Gln Gly Thr Leu 
            260 


<210>  6502
<211>  128
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6502

Xaa Asn Thr Leu Ile Cys His Ile Asp Lys Phe Phe Pro Pro Val Leu 
1               5                   10                  15      


Asn Val Thr Trp Leu Cys Asn Gly Glu Leu Val Thr Glu Gly Val Ala 
            20                  25                  30          


Glu Ser Leu Phe Leu Pro Arg Thr Asp Tyr Ser Phe His Lys Phe His 
        35                  40                  45              


Tyr Leu Thr Phe Val Pro Ser Ala Glu Asp Phe Tyr Asp Cys Arg Val 
    50                  55                  60                  


Glu His Trp Gly Leu Asp Gln Pro Leu Leu Lys His Trp Glu Ala Gln 
65                  70                  75                  80  


Glu Pro Ile Gln Met Pro Glu Thr Thr Glu Thr Val Leu Cys Ala Leu 
                85                  90                  95      


Gly Leu Val Leu Gly Leu Val Gly Ile Ile Val Gly Thr Val Leu Ile 
            100                 105                 110         


Ile Lys Ser Leu Arg Ser Gly His Asp Pro Arg Ala Gln Gly Thr Leu 
        115                 120                 125             


<210>  6503
<211>  24
<212>  PRT
<213>  Homo Sapiens

<400>  6503

Met Ile Leu Asn Lys Ala Leu Leu Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu 
            20                  


<210>  6504
<211>  255
<212>  PRT
<213>  Homo Sapiens

<400>  6504

Met Ile Leu Asn Lys Ala Leu Leu Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Cys Gly Val Asn Leu Tyr Gln Phe Tyr Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Gln Phe Tyr Val Asp Leu Glu Arg 
    50                  55                  60                  


Lys Glu Thr Ala Trp Arg Trp Pro Glu Phe Ser Lys Phe Gly Gly Phe 
65                  70                  75                  80  


Asp Pro Gln Gly Ala Leu Arg Asn Met Ala Val Ala Lys His Asn Leu 
                85                  90                  95      


Asn Ile Met Ile Lys Arg Tyr Asn Ser Thr Ala Ala Thr Asn Glu Val 
            100                 105                 110         


Pro Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro 
        115                 120                 125             


Asn Thr Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn 
    130                 135                 140                 


Ile Thr Trp Leu Ser Asn Gly Gln Ser Val Thr Glu Gly Val Ser Glu 
145                 150                 155                 160 


Thr Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr 
                165                 170                 175     


Leu Thr Phe Leu Pro Ser Ala Asp Glu Ile Tyr Asp Cys Lys Val Glu 
            180                 185                 190         


His Trp Gly Leu Asp Gln Pro Leu Leu Lys His Trp Glu Pro Glu Ile 
        195                 200                 205             


Pro Ala Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly 
    210                 215                 220                 


Leu Ser Val Gly Leu Met Gly Ile Val Val Gly Thr Val Phe Ile Ile 
225                 230                 235                 240 


Gln Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu 
                245                 250                 255 


<210>  6505
<211>  255
<212>  PRT
<213>  Homo Sapiens

<400>  6505

Met Ile Leu Asn Lys Ala Leu Leu Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Cys Gly Val Asn Leu Tyr Gln Phe Tyr Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Gln Phe Tyr Val Asp Leu Glu Arg 
    50                  55                  60                  


Lys Glu Thr Ala Trp Arg Trp Pro Glu Phe Ser Lys Phe Gly Gly Phe 
65                  70                  75                  80  


Asp Pro Gln Gly Ala Leu Arg Asn Met Ala Val Ala Lys His Asn Leu 
                85                  90                  95      


Asn Ile Met Ile Lys Arg Tyr Asn Ser Thr Ala Ala Thr Asn Glu Val 
            100                 105                 110         


Pro Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro 
        115                 120                 125             


Asn Thr Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn 
    130                 135                 140                 


Ile Thr Trp Leu Ser Asn Gly Gln Ser Val Thr Glu Gly Val Ser Glu 
145                 150                 155                 160 


Thr Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr 
                165                 170                 175     


Leu Thr Phe Leu Pro Ser Ala Asp Glu Ile Tyr Asp Cys Lys Val Glu 
            180                 185                 190         


His Trp Gly Leu Asp Gln Pro Leu Leu Lys His Trp Glu Pro Glu Ile 
        195                 200                 205             


Pro Ala Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly 
    210                 215                 220                 


Leu Ser Val Gly Leu Met Gly Ile Val Val Gly Thr Val Phe Ile Ile 
225                 230                 235                 240 


Gln Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu 
                245                 250                 255 


<210>  6506
<211>  255
<212>  PRT
<213>  Homo Sapiens

<400>  6506

Met Ile Leu Asn Lys Ala Leu Leu Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Cys Gly Val Asn Leu Tyr Gln Phe Tyr Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Gln Phe Tyr Val Asp Leu Glu Arg 
    50                  55                  60                  


Lys Glu Thr Ala Trp Arg Trp Pro Glu Phe Ser Lys Phe Gly Gly Phe 
65                  70                  75                  80  


Asp Pro Gln Gly Ala Leu Arg Asn Met Ala Val Ala Lys His Asn Leu 
                85                  90                  95      


Asn Ile Met Ile Lys Arg Tyr Asn Ser Thr Ala Ala Thr Asn Glu Val 
            100                 105                 110         


Pro Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro 
        115                 120                 125             


Asn Thr Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn 
    130                 135                 140                 


Ile Thr Trp Leu Ser Asn Gly Gln Ser Val Thr Glu Gly Val Ser Glu 
145                 150                 155                 160 


Thr Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr 
                165                 170                 175     


Leu Thr Phe Leu Pro Ser Ala Asp Glu Ile Tyr Asp Cys Lys Val Glu 
            180                 185                 190         


His Trp Gly Leu Asp Gln Pro Leu Leu Lys His Trp Glu Pro Glu Ile 
        195                 200                 205             


Pro Ala Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly 
    210                 215                 220                 


Leu Ser Val Gly Leu Met Gly Ile Val Val Gly Thr Val Phe Ile Ile 
225                 230                 235                 240 


Gln Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu 
                245                 250                 255 


<210>  6507
<211>  214
<212>  PRT
<213>  Homo Sapiens

<400>  6507

Met Ile Leu Asn Lys Ala Leu Leu Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Cys Gly Val Asn Leu Tyr Gln Phe Tyr Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Gln Phe Tyr Val Asp Leu Glu Arg 
    50                  55                  60                  


Lys Glu Thr Ala Trp Arg Trp Pro Glu Phe Ser Lys Phe Gly Gly Phe 
65                  70                  75                  80  


Asp Pro Gln Gly Ala Leu Arg Asn Met Ala Val Ala Lys His Asn Leu 
                85                  90                  95      


Asn Ile Met Ile Lys Arg Tyr Asn Ser Thr Ala Ala Thr Asn Glu Val 
            100                 105                 110         


Pro Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro 
        115                 120                 125             


Asn Thr Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn 
    130                 135                 140                 


Ile Thr Trp Leu Ser Asn Gly Gln Ser Val Thr Glu Gly Val Ser Glu 
145                 150                 155                 160 


Thr Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr 
                165                 170                 175     


Leu Thr Phe Leu Pro Ser Ala Asp Glu Ile Tyr Asp Cys Lys Val Glu 
            180                 185                 190         


His Trp Gly Leu Asp Gln Pro Leu Leu Lys His Trp Gly Ala Ser Pro 
        195                 200                 205             


Ser Thr Gly Ala Glu Glu 
    210                 


<210>  6508
<211>  53
<212>  PRT
<213>  Homo Sapiens

<400>  6508

Met Ile Leu Asn Lys Ala Leu Leu Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Gly Ser Ile Ser Asp 
            20                  25                  30          


Ser Leu Leu Leu Tyr Arg Asp Gly Gln Trp Val Cys Lys Thr Lys Val 
        35                  40                  45              


Glu Lys Ser Asp Ser 
    50              


<210>  6509
<211>  136
<212>  PRT
<213>  Homo Sapiens

<400>  6509

Met Ser Trp Lys Lys Ala Leu Arg Ile Pro Gly Asp Leu Arg Val Ala 
1               5                   10                  15      


Thr Val Thr Leu Met Leu Ala Met Leu Ser Ser Leu Leu Ala Glu Gly 
            20                  25                  30          


Arg Asp Ser Pro Glu Asp Phe Val Phe Gln Phe Lys Gly Met Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Arg Val Arg Leu Val Thr Arg Tyr Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Tyr Ala Arg Phe Asp Ser Asp Val Gly Val Tyr Arg 
65                  70                  75                  80  


Ala Val Thr Pro Gln Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln 
                85                  90                  95      


Lys Glu Val Leu Glu Gly Thr Arg Ala Glu Leu Asp Thr Val Cys Arg 
            100                 105                 110         


His Asn Tyr Glu Val Ala Phe Arg Gly Ile Leu Gln Arg Arg Gly Met 
        115                 120                 125             


Val Thr Gly Leu Ser Arg Ser Trp 
    130                 135     


<210>  6510
<211>  269
<212>  PRT
<213>  Homo Sapiens

<400>  6510

Met Ser Trp Lys Lys Ala Leu Arg Ile Pro Gly Asp Leu Arg Val Ala 
1               5                   10                  15      


Thr Val Thr Leu Met Leu Ala Met Leu Ser Ser Leu Leu Ala Glu Gly 
            20                  25                  30          


Arg Asp Ser Pro Glu Asp Phe Val Phe Gln Phe Lys Gly Met Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Arg Val Arg Leu Val Thr Arg Tyr Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Tyr Ala Arg Phe Asp Ser Asp Val Gly Val Tyr Arg 
65                  70                  75                  80  


Ala Val Thr Pro Gln Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln 
                85                  90                  95      


Lys Glu Val Leu Glu Gly Thr Arg Ala Glu Leu Asp Thr Val Cys Arg 
            100                 105                 110         


His Asn Tyr Glu Val Ala Phe Arg Gly Ile Leu Gln Arg Arg Val Glu 
        115                 120                 125             


Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
    130                 135                 140                 


Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Gly Gln Ile Lys 
145                 150                 155                 160 


Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Ala Gly Val Val Ser 
                165                 170                 175     


Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
            180                 185                 190         


Leu Glu Met Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His Val Glu 
        195                 200                 205             


His Pro Ser Leu Gln Ser Pro Ile Thr Val Glu Trp Arg Ala Gln Ser 
    210                 215                 220                 


Glu Ser Ala Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu 
225                 230                 235                 240 


Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile Arg Gln Arg Ser Gln 
                245                 250                 255     


Lys Gly Pro Gln Gly Pro Pro Pro Ala Gly Leu Leu His 
            260                 265                 


<210>  6511
<211>  261
<212>  PRT
<213>  Homo Sapiens

<400>  6511

Met Ser Trp Lys Lys Ala Leu Arg Ile Pro Gly Asp Leu Arg Val Ala 
1               5                   10                  15      


Thr Val Thr Leu Met Leu Ala Met Leu Ser Ser Leu Leu Ala Glu Gly 
            20                  25                  30          


Arg Asp Ser Pro Glu Asp Phe Val Phe Gln Phe Lys Gly Met Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Arg Val Arg Leu Val Thr Arg Tyr Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Tyr Ala Arg Phe Asp Ser Asp Val Gly Val Tyr Arg 
65                  70                  75                  80  


Ala Val Thr Pro Gln Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln 
                85                  90                  95      


Lys Glu Val Leu Glu Gly Thr Arg Ala Glu Leu Asp Thr Val Cys Arg 
            100                 105                 110         


His Asn Tyr Glu Val Ala Phe Arg Gly Ile Leu Gln Arg Arg Val Glu 
        115                 120                 125             


Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
    130                 135                 140                 


Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Gly Gln Ile Lys 
145                 150                 155                 160 


Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Ala Gly Val Val Ser 
                165                 170                 175     


Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
            180                 185                 190         


Leu Glu Met Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His Val Glu 
        195                 200                 205             


His Pro Ser Leu Gln Ser Pro Ile Thr Val Glu Trp Arg Ala Gln Ser 
    210                 215                 220                 


Glu Ser Ala Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu 
225                 230                 235                 240 


Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile Arg Gln Arg Ser Gln 
                245                 250                 255     


Lys Gly Leu Leu His 
            260     


<210>  6512
<211>  261
<212>  PRT
<213>  Homo Sapiens

<400>  6512

Met Ser Trp Lys Lys Ala Leu Arg Ile Pro Gly Asp Leu Arg Val Ala 
1               5                   10                  15      


Thr Val Thr Leu Met Leu Ala Met Leu Ser Ser Leu Leu Ala Glu Gly 
            20                  25                  30          


Arg Asp Ser Pro Glu Asp Phe Val Phe Gln Phe Lys Gly Met Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Arg Val Arg Leu Val Thr Arg Tyr Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Tyr Ala Arg Phe Asp Ser Asp Val Gly Val Tyr Arg 
65                  70                  75                  80  


Ala Val Thr Pro Gln Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln 
                85                  90                  95      


Lys Glu Val Leu Glu Gly Thr Arg Ala Glu Leu Asp Thr Val Cys Arg 
            100                 105                 110         


His Asn Tyr Glu Val Ala Phe Arg Gly Ile Leu Gln Arg Arg Val Glu 
        115                 120                 125             


Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
    130                 135                 140                 


Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Gly Gln Ile Lys 
145                 150                 155                 160 


Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Ala Gly Val Val Ser 
                165                 170                 175     


Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
            180                 185                 190         


Leu Glu Met Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His Val Glu 
        195                 200                 205             


His Pro Ser Leu Gln Ser Pro Ile Thr Val Glu Trp Arg Ala Gln Ser 
    210                 215                 220                 


Glu Ser Ala Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu 
225                 230                 235                 240 


Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile Arg Gln Arg Ser Gln 
                245                 250                 255     


Lys Gly Leu Leu His 
            260     


<210>  6513
<211>  224
<212>  PRT
<213>  Homo Sapiens

<400>  6513

Met Ser Trp Lys Lys Ala Leu Arg Ile Pro Gly Asp Leu Arg Val Ala 
1               5                   10                  15      


Thr Val Thr Leu Met Leu Ala Met Leu Ser Ser Leu Leu Ala Glu Gly 
            20                  25                  30          


Arg Asp Ser Pro Glu Asp Phe Val Phe Gln Phe Lys Gly Met Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Arg Val Arg Leu Val Thr Arg Tyr Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Tyr Ala Arg Phe Asp Ser Asp Val Gly Val Tyr Arg 
65                  70                  75                  80  


Ala Val Thr Pro Gln Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln 
                85                  90                  95      


Lys Glu Val Leu Glu Gly Thr Arg Ala Glu Leu Asp Thr Val Cys Arg 
            100                 105                 110         


His Asn Tyr Glu Val Ala Phe Arg Gly Ile Leu Gln Arg Arg Val Glu 
        115                 120                 125             


Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
    130                 135                 140                 


Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Gly Gln Ile Lys 
145                 150                 155                 160 


Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Ala Gly Val Val Ser 
                165                 170                 175     


Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
            180                 185                 190         


Leu Glu Met Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His Val Glu 
        195                 200                 205             


His Pro Ser Leu Gln Ser Pro Ile Thr Val Glu Trp Arg Leu Leu His 
    210                 215                 220                 


<210>  6514
<211>  134
<212>  PRT
<213>  Homo Sapiens

<400>  6514

Met Ser Trp Lys Lys Ala Leu Arg Ile Pro Gly Asp Leu Arg Val Ala 
1               5                   10                  15      


Thr Val Thr Leu Met Leu Ala Met Leu Ser Ser Leu Leu Ala Glu Gly 
            20                  25                  30          


Arg Asp Ser Pro Val Glu Pro Thr Val Thr Ile Ser Pro Ser Arg Thr 
        35                  40                  45              


Glu Ala Leu Asn His His Asn Leu Leu Val Cys Ser Val Thr Asp Phe 
    50                  55                  60                  


Tyr Pro Gly Gln Ile Lys Val Arg Trp Phe Arg Asn Asp Gln Glu Glu 
65                  70                  75                  80  


Thr Ala Gly Val Val Ser Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr 
                85                  90                  95      


Phe Gln Ile Leu Val Met Leu Glu Met Thr Pro Gln Arg Gly Asp Val 
            100                 105                 110         


Tyr Thr Cys His Val Glu His Pro Ser Leu Gln Ser Pro Ile Thr Val 
        115                 120                 125             


Glu Trp Arg Leu Leu His 
    130                 


<210>  6515
<211>  275
<212>  PRT
<213>  Homo Sapiens

<400>  6515

Met Ala Leu Gln Ile Pro Gly Gly Phe Trp Ala Ala Ala Val Thr Val 
1               5                   10                  15      


Met Leu Val Met Leu Ser Thr Pro Val Ala Glu Ala Arg Asp Phe Pro 
            20                  25                  30          


Lys Asp Phe Leu Val Gln Phe Lys Gly Met Cys Tyr Phe Thr Asn Gly 
        35                  40                  45              


Thr Glu Arg Val Arg Gly Val Ala Arg Tyr Ile Tyr Asn Arg Glu Glu 
    50                  55                  60                  


Tyr Gly Arg Phe Asp Ser Asp Val Gly Glu Phe Gln Ala Val Thr Glu 
65                  70                  75                  80  


Leu Gly Arg Ser Ile Glu Asp Trp Asn Asn Tyr Lys Asp Phe Leu Glu 
                85                  90                  95      


Gln Glu Arg Ala Ala Val Asp Lys Val Cys Arg His Asn Tyr Glu Ala 
            100                 105                 110         


Glu Leu Arg Thr Thr Leu Gln Arg Gln Val Glu Pro Thr Val Thr Ile 
        115                 120                 125             


Ser Pro Ser Arg Thr Glu Ala Leu Asn His His Asn Leu Leu Val Cys 
    130                 135                 140                 


Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys Val Arg Trp Phe Arg 
145                 150                 155                 160 


Asn Asp Gln Glu Glu Thr Ala Gly Val Val Ser Thr Ser Leu Ile Arg 
                165                 170                 175     


Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Ile Thr Pro 
            180                 185                 190         


Gln Arg Gly Asp Ile Tyr Thr Cys Gln Val Glu His Pro Ser Leu Gln 
        195                 200                 205             


Ser Pro Ile Thr Val Glu Trp Arg Ala Gln Ser Glu Ser Ala Gln Ser 
    210                 215                 220                 


Lys Met Leu Ser Gly Ile Gly Gly Phe Val Leu Gly Leu Ile Phe Leu 
225                 230                 235                 240 


Gly Leu Gly Leu Ile Ile Arg His Arg Gly Gln Lys Gly Pro Arg Gly 
                245                 250                 255     


Pro Pro Pro Ala Gly Asn Ile Ser Ala Met Ile Gln Ser Gly Glu Arg 
            260                 265                 270         


Ala Gln Ala 
        275 


<210>  6516
<211>  264
<212>  PRT
<213>  Homo Sapiens

<400>  6516

Met Ala Leu Gln Ile Pro Gly Gly Phe Trp Ala Ala Ala Val Thr Val 
1               5                   10                  15      


Met Leu Val Met Leu Ser Thr Pro Val Ala Glu Ala Arg Asp Phe Pro 
            20                  25                  30          


Lys Asp Phe Leu Val Gln Phe Lys Gly Met Cys Tyr Phe Thr Asn Gly 
        35                  40                  45              


Thr Glu Arg Val Arg Gly Val Ala Arg Tyr Ile Tyr Asn Arg Glu Glu 
    50                  55                  60                  


Tyr Gly Arg Phe Asp Ser Asp Val Gly Glu Phe Gln Ala Val Thr Glu 
65                  70                  75                  80  


Leu Gly Arg Ser Ile Glu Asp Trp Asn Asn Tyr Lys Asp Phe Leu Glu 
                85                  90                  95      


Gln Glu Arg Ala Ala Val Asp Lys Val Cys Arg His Asn Tyr Glu Ala 
            100                 105                 110         


Glu Leu Arg Thr Thr Leu Gln Arg Gln Val Glu Pro Thr Val Thr Ile 
        115                 120                 125             


Ser Pro Ser Arg Thr Glu Ala Leu Asn His His Asn Leu Leu Val Cys 
    130                 135                 140                 


Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys Val Arg Trp Phe Arg 
145                 150                 155                 160 


Asn Asp Gln Glu Glu Thr Ala Gly Val Val Ser Thr Ser Leu Ile Arg 
                165                 170                 175     


Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Ile Thr Pro 
            180                 185                 190         


Gln Arg Gly Asp Ile Tyr Thr Cys Gln Val Glu His Pro Ser Leu Gln 
        195                 200                 205             


Ser Pro Ile Thr Val Glu Trp Arg Ala Gln Ser Glu Ser Ala Gln Ser 
    210                 215                 220                 


Lys Met Leu Ser Gly Ile Gly Gly Phe Val Leu Gly Leu Ile Phe Leu 
225                 230                 235                 240 


Gly Leu Gly Leu Ile Ile Arg His Arg Gly Gln Lys Gly Pro Arg Gly 
                245                 250                 255     


Pro Pro Pro Ala Gly Leu Leu His 
            260                 


<210>  6517
<211>  227
<212>  PRT
<213>  Homo Sapiens

<400>  6517

Met Ala Leu Gln Ile Pro Gly Gly Phe Trp Ala Ala Ala Val Thr Val 
1               5                   10                  15      


Met Leu Val Met Leu Ser Thr Pro Val Ala Glu Ala Arg Asp Phe Pro 
            20                  25                  30          


Lys Asp Phe Leu Val Gln Phe Lys Gly Met Cys Tyr Phe Thr Asn Gly 
        35                  40                  45              


Thr Glu Arg Val Arg Gly Val Ala Arg Tyr Ile Tyr Asn Arg Glu Glu 
    50                  55                  60                  


Tyr Gly Arg Phe Asp Ser Asp Val Gly Glu Phe Gln Ala Val Thr Glu 
65                  70                  75                  80  


Leu Gly Arg Ser Ile Glu Asp Trp Asn Asn Tyr Lys Asp Phe Leu Glu 
                85                  90                  95      


Gln Glu Arg Ala Ala Val Asp Lys Val Cys Arg His Asn Tyr Glu Ala 
            100                 105                 110         


Glu Leu Arg Thr Thr Leu Gln Arg Gln Val Glu Pro Thr Val Thr Ile 
        115                 120                 125             


Ser Pro Ser Arg Thr Glu Ala Leu Asn His His Asn Leu Leu Val Cys 
    130                 135                 140                 


Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys Val Arg Trp Phe Arg 
145                 150                 155                 160 


Asn Asp Gln Glu Glu Thr Ala Gly Val Val Ser Thr Ser Leu Ile Arg 
                165                 170                 175     


Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Ile Thr Pro 
            180                 185                 190         


Gln Arg Gly Asp Ile Tyr Thr Cys Gln Val Glu His Pro Ser Leu Gln 
        195                 200                 205             


Ser Pro Ile Thr Val Glu Trp Arg Pro Arg Gly Pro Pro Pro Ala Gly 
    210                 215                 220                 


Leu Leu His 
225         


<210>  6518
<211>  218
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6518

Xaa Leu Gln Ile Pro Gly Gly Phe Trp Ala Ala Ala Val Thr Val Met 
1               5                   10                  15      


Leu Val Met Leu Ser Thr Pro Val Ala Glu Ala Arg Asp Phe Pro Lys 
            20                  25                  30          


Asp Phe Leu Val Gln Phe Lys Gly Met Cys Tyr Phe Thr Asn Gly Thr 
        35                  40                  45              


Glu Arg Val Arg Gly Val Ala Arg Tyr Ile Tyr Asn Arg Glu Glu Tyr 
    50                  55                  60                  


Gly Arg Phe Asp Ser Asp Val Gly Glu Phe Gln Ala Val Thr Glu Leu 
65                  70                  75                  80  


Gly Arg Ser Ile Glu Asp Trp Asn Asn Tyr Lys Asp Phe Leu Glu Gln 
                85                  90                  95      


Glu Arg Ala Ala Val Asp Lys Val Cys Arg His Asn Tyr Glu Ala Glu 
            100                 105                 110         


Leu Arg Thr Thr Leu Gln Arg Gln Val Glu Pro Thr Val Thr Ile Ser 
        115                 120                 125             


Pro Ser Arg Thr Glu Ala Leu Asn His His Asn Leu Leu Val Cys Ser 
    130                 135                 140                 


Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys Val Arg Trp Phe Arg Asn 
145                 150                 155                 160 


Asp Gln Glu Glu Thr Ala Gly Val Val Ser Thr Ser Leu Ile Arg Asn 
                165                 170                 175     


Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Ile Thr Pro Gln 
            180                 185                 190         


Arg Gly Asp Ile Tyr Thr Cys Gln Val Glu His Pro Ser Leu Gln Ser 
        195                 200                 205             


Pro Ile Thr Val Glu Trp Arg Leu Leu His 
    210                 215             


<210>  6519
<211>  240
<212>  PRT
<213>  Homo Sapiens

<400>  6519

Ala Ile Gly Ser Phe His Cys Gly Cys Glu Pro Gly Tyr Gln Leu Lys 
1               5                   10                  15      


Gly Arg Lys Cys Met Asp Val Asn Glu Cys Arg Gln Asn Val Cys Arg 
            20                  25                  30          


Pro Asp Gln His Cys Lys Asn Thr Arg Gly Gly Tyr Lys Cys Ile Asp 
        35                  40                  45              


Leu Cys Pro Asn Gly Met Thr Lys Ala Glu Asn Gly Thr Cys Ile Asp 
    50                  55                  60                  


Ile Asp Glu Cys Lys Asp Gly Thr His Gln Cys Arg Tyr Asn Gln Ile 
65                  70                  75                  80  


Cys Glu Asn Thr Arg Gly Ser Tyr Arg Cys Val Cys Pro Arg Gly Tyr 
                85                  90                  95      


Arg Ser Gln Gly Val Gly Arg Pro Cys Met Asp Ile Asp Glu Cys Glu 
            100                 105                 110         


Asn Thr Asp Ala Cys Gln His Glu Cys Lys Asn Thr Phe Gly Ser Tyr 
        115                 120                 125             


Gln Cys Ile Cys Pro Pro Gly Tyr Gln Leu Thr His Asn Gly Lys Thr 
    130                 135                 140                 


Cys Gln Asp Ile Asp Glu Cys Leu Glu Gln Asn Val His Cys Gly Pro 
145                 150                 155                 160 


Asn Arg Met Cys Phe Asn Met Arg Gly Ser Tyr Gln Cys Ile Asp Thr 
                165                 170                 175     


Pro Cys Pro Pro Asn Tyr Gln Arg Asp Pro Val Ser Gly Phe Cys Leu 
            180                 185                 190         


Lys Asn Cys Pro Pro Asn Asp Leu Glu Cys Ala Leu Ser Pro Tyr Ala 
        195                 200                 205             


Leu Glu Tyr Lys Leu Val Ser Leu Pro Phe Gly Ile Ala Thr Asn Gln 
    210                 215                 220                 


Asp Leu Ile Arg Leu Val Ala Tyr Thr Gln Asp Gly Val Met His Pro 
225                 230                 235                 240 


<210>  6520
<211>  5635
<212>  PRT
<213>  Homo Sapiens

<400>  6520

Met Ile Ser Trp Glu Val Val His Thr Val Phe Leu Phe Ala Leu Leu 
1               5                   10                  15      


Tyr Ser Ser Leu Ala Gln Asp Ala Ser Pro Gln Ser Glu Ile Arg Ala 
            20                  25                  30          


Glu Glu Ile Pro Glu Gly Ala Ser Thr Leu Ala Phe Val Phe Asp Val 
        35                  40                  45              


Thr Gly Ser Met Tyr Asp Asp Leu Val Gln Val Ile Glu Gly Ala Ser 
    50                  55                  60                  


Lys Ile Leu Glu Thr Ser Leu Lys Arg Pro Lys Arg Pro Leu Phe Asn 
65                  70                  75                  80  


Phe Ala Leu Val Pro Phe His Asp Pro Glu Ile Gly Pro Val Thr Ile 
                85                  90                  95      


Thr Thr Asp Pro Lys Lys Phe Gln Tyr Glu Leu Arg Glu Leu Tyr Val 
            100                 105                 110         


Gln Gly Gly Gly Asp Cys Pro Glu Met Ser Ile Gly Ala Ile Lys Ile 
        115                 120                 125             


Ala Leu Glu Ile Ser Leu Pro Gly Ser Phe Ile Tyr Val Phe Thr Asp 
    130                 135                 140                 


Ala Arg Ser Lys Asp Tyr Arg Leu Thr His Glu Val Leu Gln Leu Ile 
145                 150                 155                 160 


Gln Gln Lys Gln Ser Gln Val Val Phe Val Leu Thr Gly Asp Cys Asp 
                165                 170                 175     


Asp Arg Thr His Ile Gly Tyr Lys Val Tyr Glu Glu Ile Ala Ser Thr 
            180                 185                 190         


Ser Ser Gly Gln Val Phe His Leu Asp Lys Lys Gln Val Asn Glu Val 
        195                 200                 205             


Leu Lys Trp Val Glu Glu Ala Val Gln Ala Ser Lys Val His Leu Leu 
    210                 215                 220                 


Ser Thr Asp His Leu Glu Gln Ala Val Asn Thr Trp Arg Ile Pro Phe 
225                 230                 235                 240 


Asp Pro Ser Leu Lys Glu Val Thr Val Ser Leu Ser Gly Pro Ser Pro 
                245                 250                 255     


Met Ile Glu Ile Arg Asn Pro Leu Gly Lys Leu Ile Lys Lys Gly Phe 
            260                 265                 270         


Gly Leu His Glu Leu Leu Asn Ile His Asn Ser Ala Lys Val Val Asn 
        275                 280                 285             


Val Lys Glu Pro Glu Ala Gly Met Trp Thr Val Lys Thr Ser Ser Ser 
    290                 295                 300                 


Gly Arg His Ser Val Arg Ile Thr Gly Leu Ser Thr Ile Asp Phe Arg 
305                 310                 315                 320 


Ala Gly Phe Ser Arg Lys Pro Thr Leu Asp Phe Lys Lys Thr Val Ser 
                325                 330                 335     


Arg Pro Val Gln Gly Ile Pro Thr Tyr Val Leu Leu Asn Thr Ser Gly 
            340                 345                 350         


Ile Ser Thr Pro Ala Arg Ile Asp Leu Leu Glu Leu Leu Ser Ile Ser 
        355                 360                 365             


Gly Ser Ser Leu Lys Thr Ile Pro Val Lys Tyr Tyr Pro His Arg Lys 
    370                 375                 380                 


Pro Tyr Gly Ile Trp Asn Ile Ser Asp Phe Val Pro Pro Asn Glu Ala 
385                 390                 395                 400 


Phe Phe Leu Lys Val Thr Gly Tyr Asp Lys Asp Asp Tyr Leu Phe Gln 
                405                 410                 415     


Arg Val Ser Ser Val Ser Phe Ser Ser Ile Val Pro Asp Ala Pro Lys 
            420                 425                 430         


Val Thr Met Pro Glu Lys Thr Pro Gly Tyr Tyr Leu Gln Pro Gly Gln 
        435                 440                 445             


Ile Pro Cys Ser Val Asp Ser Leu Leu Pro Phe Thr Leu Ser Phe Val 
    450                 455                 460                 


Arg Asn Gly Val Thr Leu Gly Val Asp Gln Tyr Leu Lys Glu Ser Ala 
465                 470                 475                 480 


Ser Val Asn Leu Asp Ile Ala Lys Val Thr Leu Ser Asp Glu Gly Phe 
                485                 490                 495     


Tyr Glu Cys Ile Ala Val Ser Ser Ala Gly Thr Gly Arg Ala Gln Thr 
            500                 505                 510         


Phe Phe Asp Val Ser Glu Pro Pro Pro Val Ile Gln Val Pro Asn Asn 
        515                 520                 525             


Val Thr Val Thr Pro Gly Glu Arg Ala Val Leu Thr Cys Leu Ile Ile 
    530                 535                 540                 


Ser Ala Val Asp Tyr Asn Leu Thr Trp Gln Arg Asn Asp Arg Asp Val 
545                 550                 555                 560 


Arg Leu Ala Glu Pro Ala Arg Ile Arg Thr Leu Ala Asn Leu Ser Leu 
                565                 570                 575     


Glu Leu Lys Ser Val Lys Phe Asn Asp Ala Gly Glu Tyr His Cys Met 
            580                 585                 590         


Val Ser Ser Glu Gly Gly Ser Ser Ala Ala Ser Val Phe Leu Thr Val 
        595                 600                 605             


Gln Glu Pro Pro Lys Val Thr Val Met Pro Lys Asn Gln Ser Phe Thr 
    610                 615                 620                 


Gly Gly Ser Glu Val Ser Ile Met Cys Ser Ala Thr Gly Tyr Pro Lys 
625                 630                 635                 640 


Pro Lys Ile Ala Trp Thr Val Asn Asp Met Phe Ile Val Gly Ser His 
                645                 650                 655     


Arg Tyr Arg Met Thr Ser Asp Gly Thr Leu Phe Ile Lys Asn Ala Ala 
            660                 665                 670         


Pro Lys Asp Ala Gly Ile Tyr Gly Cys Leu Ala Ser Asn Ser Ala Gly 
        675                 680                 685             


Thr Asp Lys Gln Asn Ser Thr Leu Arg Tyr Ile Glu Ala Pro Lys Leu 
    690                 695                 700                 


Met Val Val Gln Ser Glu Leu Leu Val Ala Leu Gly Asp Ile Thr Val 
705                 710                 715                 720 


Met Glu Cys Lys Thr Ser Gly Ile Pro Pro Pro Gln Val Lys Trp Phe 
                725                 730                 735     


Lys Gly Asp Leu Glu Leu Arg Pro Ser Thr Phe Leu Ile Ile Asp Pro 
            740                 745                 750         


Leu Leu Gly Leu Leu Lys Ile Gln Glu Thr Gln Asp Leu Asp Ala Gly 
        755                 760                 765             


Asp Tyr Thr Cys Val Ala Ile Asn Glu Ala Gly Arg Ala Thr Gly Lys 
    770                 775                 780                 


Ile Thr Leu Asp Val Gly Ser Pro Pro Val Phe Ile Gln Glu Pro Ala 
785                 790                 795                 800 


Asp Val Ser Met Glu Ile Gly Ser Asn Val Thr Leu Pro Cys Tyr Val 
                805                 810                 815     


Gln Gly Tyr Pro Glu Pro Thr Ile Lys Trp Arg Arg Leu Asp Asn Met 
            820                 825                 830         


Pro Ile Phe Ser Arg Pro Phe Ser Val Ser Ser Ile Ser Gln Leu Arg 
        835                 840                 845             


Thr Gly Ala Leu Phe Ile Leu Asn Leu Trp Ala Ser Asp Lys Gly Thr 
    850                 855                 860                 


Tyr Ile Cys Glu Ala Glu Asn Gln Phe Gly Lys Ile Gln Ser Glu Thr 
865                 870                 875                 880 


Thr Val Thr Val Thr Gly Leu Val Ala Pro Leu Ile Gly Ile Ser Pro 
                885                 890                 895     


Ser Val Ala Asn Val Ile Glu Gly Gln Gln Leu Thr Leu Pro Cys Thr 
            900                 905                 910         


Leu Leu Ala Gly Asn Pro Ile Pro Glu Arg Arg Trp Ile Lys Asn Ser 
        915                 920                 925             


Ala Met Leu Leu Gln Asn Pro Tyr Ile Thr Val Arg Ser Asp Gly Ser 
    930                 935                 940                 


Leu His Ile Glu Arg Val Gln Leu Gln Asp Gly Gly Glu Tyr Thr Cys 
945                 950                 955                 960 


Val Ala Ser Asn Val Ala Gly Thr Asn Asn Lys Thr Thr Ser Val Val 
                965                 970                 975     


Val His Val Leu Pro Thr Ile Gln His Gly Gln Gln Ile Leu Ser Thr 
            980                 985                 990         


Ile Glu Gly Ile Pro Val Thr Leu  Pro Cys Lys Ala Ser  Gly Asn Pro 
        995                 1000                 1005             


Lys Pro  Ser Val Ile Trp Ser  Lys Lys Gly Glu Leu  Ile Ser Thr 
    1010                 1015                 1020             


Ser Ser  Ala Lys Phe Ser Ala  Gly Ala Asp Gly Ser  Leu Tyr Val 
    1025                 1030                 1035             


Val Ser  Pro Gly Gly Glu Glu  Ser Gly Glu Tyr Val  Cys Thr Ala 
    1040                 1045                 1050             


Thr Asn  Thr Ala Gly Tyr Ala  Lys Arg Lys Val Gln  Leu Thr Val 
    1055                 1060                 1065             


Tyr Val  Arg Pro Arg Val Phe  Gly Asp Gln Arg Gly  Leu Ser Gln 
    1070                 1075                 1080             


Asp Lys  Pro Val Glu Ile Ser  Val Leu Ala Gly Glu  Glu Val Thr 
    1085                 1090                 1095             


Leu Pro  Cys Glu Val Lys Ser  Leu Pro Pro Pro Ile  Ile Thr Trp 
    1100                 1105                 1110             


Ala Lys  Glu Thr Gln Leu Ile  Ser Pro Phe Ser Pro  Arg His Thr 
    1115                 1120                 1125             


Phe Leu  Pro Ser Gly Ser Met  Lys Ile Thr Glu Thr  Arg Thr Ser 
    1130                 1135                 1140             


Asp Ser  Gly Met Tyr Leu Cys  Val Ala Thr Asn Ile  Ala Gly Asn 
    1145                 1150                 1155             


Val Thr  Gln Ala Val Lys Leu  Asn Val His Val Pro  Pro Lys Ile 
    1160                 1165                 1170             


Gln Arg  Gly Pro Lys His Leu  Lys Val Gln Val Gly  Gln Arg Val 
    1175                 1180                 1185             


Asp Ile  Pro Cys Asn Ala Gln  Gly Thr Pro Leu Pro  Val Ile Thr 
    1190                 1195                 1200             


Trp Ser  Lys Gly Gly Ser Thr  Met Leu Val Asp Gly  Glu His His 
    1205                 1210                 1215             


Val Ser  Asn Pro Asp Gly Thr  Leu Ser Ile Asp Gln  Ala Thr Pro 
    1220                 1225                 1230             


Ser Asp  Ala Gly Ile Tyr Thr  Cys Val Ala Thr Asn  Ile Ala Gly 
    1235                 1240                 1245             


Thr Asp  Glu Thr Glu Ile Thr  Leu His Val Gln Glu  Pro Pro Thr 
    1250                 1255                 1260             


Val Glu  Asp Leu Glu Pro Pro  Tyr Asn Thr Thr Phe  Gln Glu Arg 
    1265                 1270                 1275             


Val Ala  Asn Gln Arg Ile Glu  Phe Pro Cys Pro Ala  Lys Gly Thr 
    1280                 1285                 1290             


Pro Lys  Pro Thr Ile Lys Trp  Leu His Asn Gly Arg  Glu Leu Thr 
    1295                 1300                 1305             


Gly Arg  Glu Pro Gly Ile Ser  Ile Leu Glu Asp Gly  Thr Leu Leu 
    1310                 1315                 1320             


Val Ile  Ala Ser Val Thr Pro  Tyr Asp Asn Gly Glu  Tyr Ile Cys 
    1325                 1330                 1335             


Val Ala  Val Asn Glu Ala Gly  Thr Thr Glu Arg Lys  Tyr Asn Leu 
    1340                 1345                 1350             


Lys Val  His Val Pro Pro Val  Ile Lys Asp Lys Glu  Gln Val Thr 
    1355                 1360                 1365             


Asn Val  Ser Val Leu Leu Asn  Gln Leu Thr Asn Leu  Phe Cys Glu 
    1370                 1375                 1380             


Val Glu  Gly Thr Pro Ser Pro  Ile Ile Met Trp Tyr  Lys Asp Asn 
    1385                 1390                 1395             


Val Gln  Val Thr Glu Ser Ser  Thr Ile Gln Thr Val  Asn Asn Gly 
    1400                 1405                 1410             


Lys Ile  Leu Lys Leu Phe Arg  Ala Thr Pro Glu Asp  Ala Gly Arg 
    1415                 1420                 1425             


Tyr Ser  Cys Lys Ala Ile Asn  Ile Ala Gly Thr Ser  Gln Lys Tyr 
    1430                 1435                 1440             


Phe Asn  Ile Asp Val Leu Val  Pro Pro Thr Ile Ile  Gly Thr Asn 
    1445                 1450                 1455             


Phe Pro  Asn Glu Val Ser Val  Val Leu Asn Arg Asp  Val Ala Leu 
    1460                 1465                 1470             


Glu Cys  Gln Val Lys Gly Thr  Pro Phe Pro Asp Ile  His Trp Phe 
    1475                 1480                 1485             


Lys Asp  Gly Lys Pro Leu Phe  Leu Gly Asp Pro Asn  Val Glu Leu 
    1490                 1495                 1500             


Leu Asp  Arg Gly Gln Val Leu  His Leu Lys Asn Ala  Arg Arg Asn 
    1505                 1510                 1515             


Asp Lys  Gly Arg Tyr Gln Cys  Thr Val Ser Asn Ala  Ala Gly Lys 
    1520                 1525                 1530             


Gln Ala  Lys Asp Ile Lys Leu  Thr Ile Tyr Ile Pro  Pro Ser Ile 
    1535                 1540                 1545             


Lys Gly  Gly Asn Val Thr Thr  Asp Ile Ser Val Leu  Ile Asn Ser 
    1550                 1555                 1560             


Leu Ile  Lys Leu Glu Cys Glu  Thr Arg Gly Leu Pro  Met Pro Ala 
    1565                 1570                 1575             


Ile Thr  Trp Tyr Lys Asp Gly  Gln Pro Ile Met Ser  Ser Ser Gln 
    1580                 1585                 1590             


Ala Leu  Tyr Ile Asp Lys Gly  Gln Tyr Leu His Ile  Pro Arg Ala 
    1595                 1600                 1605             


Gln Val  Ser Asp Ser Ala Thr  Tyr Thr Cys His Val  Ala Asn Val 
    1610                 1615                 1620             


Ala Gly  Thr Ala Glu Lys Ser  Phe His Val Asp Val  Tyr Val Pro 
    1625                 1630                 1635             


Pro Met  Ile Glu Gly Asn Leu  Ala Thr Pro Leu Asn  Lys Gln Val 
    1640                 1645                 1650             


Val Ile  Ala His Ser Leu Thr  Leu Glu Cys Lys Ala  Ala Gly Asn 
    1655                 1660                 1665             


Pro Ser  Pro Ile Leu Thr Trp  Leu Lys Asp Gly Val  Pro Val Lys 
    1670                 1675                 1680             


Ala Asn  Asp Asn Ile Arg Ile  Glu Ala Gly Gly Lys  Lys Leu Glu 
    1685                 1690                 1695             


Ile Met  Ser Ala Gln Glu Ile  Asp Arg Gly Gln Tyr  Ile Cys Val 
    1700                 1705                 1710             


Ala Thr  Ser Val Ala Gly Glu  Lys Glu Ile Lys Tyr  Glu Val Asp 
    1715                 1720                 1725             


Val Leu  Val Pro Pro Ala Ile  Glu Gly Gly Asp Glu  Thr Ser Tyr 
    1730                 1735                 1740             


Phe Ile  Val Met Val Asn Asn  Leu Leu Glu Leu Asp  Cys His Val 
    1745                 1750                 1755             


Thr Gly  Ser Pro Pro Pro Thr  Ile Met Trp Leu Lys  Asp Gly Gln 
    1760                 1765                 1770             


Leu Ile  Asp Glu Arg Asp Gly  Phe Lys Ile Leu Leu  Asn Gly Arg 
    1775                 1780                 1785             


Lys Leu  Val Ile Ala Gln Ala  Gln Val Ser Asn Thr  Gly Leu Tyr 
    1790                 1795                 1800             


Arg Cys  Met Ala Ala Asn Thr  Ala Gly Asp His Lys  Lys Glu Phe 
    1805                 1810                 1815             


Glu Val  Thr Val His Val Pro  Pro Thr Ile Lys Ser  Ser Gly Leu 
    1820                 1825                 1830             


Ser Glu  Arg Val Val Val Lys  Tyr Lys Pro Val Ala  Leu Gln Cys 
    1835                 1840                 1845             


Ile Ala  Asn Gly Ile Pro Asn  Pro Ser Ile Thr Trp  Leu Lys Asp 
    1850                 1855                 1860             


Asp Gln  Pro Val Asn Thr Ala  Gln Gly Asn Leu Lys  Ile Gln Ser 
    1865                 1870                 1875             


Ser Gly  Arg Val Leu Gln Ile  Ala Lys Thr Leu Leu  Glu Asp Ala 
    1880                 1885                 1890             


Gly Arg  Tyr Thr Cys Val Ala  Thr Asn Ala Ala Gly  Glu Thr Gln 
    1895                 1900                 1905             


Gln His  Ile Gln Leu His Val  His Glu Pro Pro Ser  Leu Glu Asp 
    1910                 1915                 1920             


Ala Gly  Lys Met Leu Asn Glu  Thr Val Leu Val Ser  Asn Pro Val 
    1925                 1930                 1935             


Gln Leu  Glu Cys Lys Ala Ala  Gly Asn Pro Val Pro  Val Ile Thr 
    1940                 1945                 1950             


Trp Tyr  Lys Asp Asn Arg Leu  Leu Ser Gly Ser Thr  Ser Met Thr 
    1955                 1960                 1965             


Phe Leu  Asn Arg Gly Gln Ile  Ile Asp Ile Glu Ser  Ala Gln Ile 
    1970                 1975                 1980             


Ser Asp  Ala Gly Ile Tyr Lys  Cys Val Ala Ile Asn  Ser Ala Gly 
    1985                 1990                 1995             


Ala Thr  Glu Leu Phe Tyr Ser  Leu Gln Val His Val  Ala Pro Ser 
    2000                 2005                 2010             


Ile Ser  Gly Ser Asn Asn Met  Val Ala Val Val Val  Asn Asn Pro 
    2015                 2020                 2025             


Val Arg  Leu Glu Cys Glu Ala  Arg Gly Ile Pro Ala  Pro Ser Leu 
    2030                 2035                 2040             


Thr Trp  Leu Lys Asp Gly Ser  Pro Val Ser Ser Phe  Ser Asn Gly 
    2045                 2050                 2055             


Leu Gln  Val Leu Ser Gly Gly  Arg Ile Leu Ala Leu  Thr Ser Ala 
    2060                 2065                 2070             


Gln Ile  Ser Asp Thr Gly Arg  Tyr Thr Cys Val Ala  Val Asn Ala 
    2075                 2080                 2085             


Ala Gly  Glu Lys Gln Arg Asp  Ile Asp Leu Arg Val  Tyr Val Pro 
    2090                 2095                 2100             


Pro Asn  Ile Met Gly Glu Glu  Gln Asn Val Ser Val  Leu Ile Ser 
    2105                 2110                 2115             


Gln Ala  Val Glu Leu Leu Cys  Gln Ser Asp Ala Ile  Pro Pro Pro 
    2120                 2125                 2130             


Thr Leu  Thr Trp Leu Lys Asp  Gly His Pro Leu Leu  Lys Lys Pro 
    2135                 2140                 2145             


Gly Leu  Ser Ile Ser Glu Asn  Arg Ser Val Leu Lys  Ile Glu Asp 
    2150                 2155                 2160             


Ala Gln  Val Gln Asp Thr Gly  Arg Tyr Thr Cys Glu  Ala Thr Asn 
    2165                 2170                 2175             


Val Ala  Gly Lys Thr Glu Lys  Asn Tyr Asn Val Asn  Ile Trp Val 
    2180                 2185                 2190             


Pro Pro  Asn Ile Gly Gly Ser  Asp Glu Leu Thr Gln  Leu Thr Val 
    2195                 2200                 2205             


Ile Glu  Gly Asn Leu Ile Ser  Leu Leu Cys Glu Ser  Ser Gly Ile 
    2210                 2215                 2220             


Pro Pro  Pro Asn Leu Ile Trp  Lys Lys Lys Gly Ser  Pro Val Leu 
    2225                 2230                 2235             


Thr Asp  Ser Met Gly Arg Val  Arg Ile Leu Ser Gly  Gly Arg Gln 
    2240                 2245                 2250             


Leu Gln  Ile Ser Ile Ala Glu  Lys Ser Asp Ala Ala  Leu Tyr Ser 
    2255                 2260                 2265             


Cys Val  Ala Ser Asn Val Ala  Gly Thr Ala Lys Lys  Glu Tyr Asn 
    2270                 2275                 2280             


Leu Gln  Val Tyr Ile Arg Pro  Thr Ile Thr Asn Ser  Gly Ser His 
    2285                 2290                 2295             


Pro Thr  Glu Ile Ile Val Thr  Arg Gly Lys Ser Ile  Ser Leu Glu 
    2300                 2305                 2310             


Cys Glu  Val Gln Gly Ile Pro  Pro Pro Thr Val Thr  Trp Met Lys 
    2315                 2320                 2325             


Asp Gly  His Pro Leu Ile Lys  Ala Lys Gly Val Glu  Ile Leu Asp 
    2330                 2335                 2340             


Glu Gly  His Ile Leu Gln Leu  Lys Asn Ile His Val  Ser Asp Thr 
    2345                 2350                 2355             


Gly Arg  Tyr Val Cys Val Ala  Val Asn Val Ala Gly  Met Thr Asp 
    2360                 2365                 2370             


Lys Lys  Tyr Asp Leu Ser Val  His Ala Pro Pro Ser  Ile Ile Gly 
    2375                 2380                 2385             


Asn His  Arg Ser Pro Glu Asn  Ile Ser Val Val Glu  Lys Asn Ser 
    2390                 2395                 2400             


Val Ser  Leu Thr Cys Glu Ala  Ser Gly Ile Pro Leu  Pro Ser Ile 
    2405                 2410                 2415             


Thr Trp  Phe Lys Asp Gly Trp  Pro Val Ser Leu Ser  Asn Ser Val 
    2420                 2425                 2430             


Arg Ile  Leu Ser Gly Gly Arg  Met Leu Arg Leu Met  Gln Thr Thr 
    2435                 2440                 2445             


Met Glu  Asp Ala Gly Gln Tyr  Thr Cys Val Val Arg  Asn Ala Ala 
    2450                 2455                 2460             


Gly Glu  Glu Arg Lys Ile Phe  Gly Leu Ser Val Leu  Val Pro Pro 
    2465                 2470                 2475             


His Ile  Val Gly Glu Asn Thr  Leu Glu Asp Val Lys  Val Lys Glu 
    2480                 2485                 2490             


Lys Gln  Ser Val Thr Leu Thr  Cys Glu Val Thr Gly  Asn Pro Val 
    2495                 2500                 2505             


Pro Glu  Ile Thr Trp His Lys  Asp Gly Gln Pro Leu  Gln Glu Asp 
    2510                 2515                 2520             


Glu Ala  His His Ile Ile Ser  Gly Gly Arg Phe Leu  Gln Ile Thr 
    2525                 2530                 2535             


Asn Val  Gln Val Pro His Thr  Gly Arg Tyr Thr Cys  Leu Ala Ser 
    2540                 2545                 2550             


Ser Pro  Ala Gly His Lys Ser  Arg Ser Phe Ser Leu  Asn Val Phe 
    2555                 2560                 2565             


Val Ser  Pro Thr Ile Ala Gly  Val Gly Ser Asp Gly  Asn Pro Glu 
    2570                 2575                 2580             


Asp Val  Thr Val Ile Leu Asn  Ser Pro Thr Ser Leu  Val Cys Glu 
    2585                 2590                 2595             


Ala Tyr  Ser Tyr Pro Pro Ala  Thr Ile Thr Trp Phe  Lys Asp Gly 
    2600                 2605                 2610             


Thr Pro  Leu Glu Ser Asn Arg  Asn Ile Arg Ile Leu  Pro Gly Gly 
    2615                 2620                 2625             


Arg Thr  Leu Gln Ile Leu Asn  Ala Gln Glu Asp Asn  Ala Gly Arg 
    2630                 2635                 2640             


Tyr Ser  Cys Val Ala Thr Asn  Glu Ala Gly Glu Met  Ile Lys His 
    2645                 2650                 2655             


Tyr Glu  Val Lys Val Tyr Ile  Pro Pro Ile Ile Asn  Lys Gly Asp 
    2660                 2665                 2670             


Leu Trp  Gly Pro Gly Leu Ser  Pro Lys Glu Val Lys  Ile Lys Val 
    2675                 2680                 2685             


Asn Asn  Thr Leu Thr Leu Glu  Cys Glu Ala Tyr Ala  Ile Pro Ser 
    2690                 2695                 2700             


Ala Ser  Leu Ser Trp Tyr Lys  Asp Gly Gln Pro Leu  Lys Ser Asp 
    2705                 2710                 2715             


Asp His  Val Asn Ile Ala Ala  Asn Gly His Thr Leu  Gln Ile Lys 
    2720                 2725                 2730             


Glu Ala  Gln Ile Ser Asp Thr  Gly Arg Tyr Thr Cys  Val Ala Ser 
    2735                 2740                 2745             


Asn Ile  Ala Gly Glu Asp Glu  Leu Asp Phe Asp Val  Asn Ile Gln 
    2750                 2755                 2760             


Val Pro  Pro Ser Phe Gln Lys  Leu Trp Glu Ile Gly  Asn Met Leu 
    2765                 2770                 2775             


Asp Thr  Gly Arg Asn Gly Glu  Ala Lys Asp Val Ile  Ile Asn Asn 
    2780                 2785                 2790             


Pro Ile  Ser Leu Tyr Cys Glu  Thr Asn Ala Ala Pro  Pro Pro Thr 
    2795                 2800                 2805             


Leu Thr  Trp Tyr Lys Asp Gly  His Pro Leu Thr Ser  Ser Asp Lys 
    2810                 2815                 2820             


Val Leu  Ile Leu Pro Gly Gly  Arg Val Leu Gln Ile  Pro Arg Ala 
    2825                 2830                 2835             


Lys Val  Glu Asp Ala Gly Arg  Tyr Thr Cys Val Ala  Val Asn Glu 
    2840                 2845                 2850             


Ala Gly  Glu Asp Ser Leu Gln  Tyr Asp Val Arg Val  Leu Val Pro 
    2855                 2860                 2865             


Pro Ile  Ile Lys Gly Ala Asn  Ser Asp Leu Pro Glu  Glu Val Thr 
    2870                 2875                 2880             


Val Leu  Val Asn Lys Ser Ala  Leu Ile Glu Cys Leu  Ser Ser Gly 
    2885                 2890                 2895             


Ser Pro  Ala Pro Arg Asn Ser  Trp Gln Lys Asp Gly  Gln Pro Leu 
    2900                 2905                 2910             


Leu Glu  Asp Asp His His Lys  Phe Leu Ser Asn Gly  Arg Ile Leu 
    2915                 2920                 2925             


Gln Ile  Leu Asn Thr Gln Ile  Thr Asp Ile Gly Arg  Tyr Val Cys 
    2930                 2935                 2940             


Val Ala  Glu Asn Thr Ala Gly  Ser Ala Lys Lys Tyr  Phe Asn Leu 
    2945                 2950                 2955             


Asn Val  His Val Pro Pro Ser  Val Ile Gly Pro Lys  Ser Glu Asn 
    2960                 2965                 2970             


Leu Thr  Val Val Val Asn Asn  Phe Ile Ser Leu Thr  Cys Glu Val 
    2975                 2980                 2985             


Ser Gly  Phe Pro Pro Pro Asp  Leu Ser Trp Leu Lys  Asn Glu Gln 
    2990                 2995                 3000             


Pro Ile  Lys Leu Asn Thr Asn  Thr Leu Ile Val Pro  Gly Gly Arg 
    3005                 3010                 3015             


Thr Leu  Gln Ile Ile Arg Ala  Lys Val Ser Asp Gly  Gly Glu Tyr 
    3020                 3025                 3030             


Thr Cys  Ile Ala Ile Asn Gln  Ala Gly Glu Ser Lys  Lys Lys Phe 
    3035                 3040                 3045             


Ser Leu  Thr Val Tyr Val Pro  Pro Ser Ile Lys Asp  His Asp Ser 
    3050                 3055                 3060             


Glu Ser  Leu Ser Val Val Asn  Val Arg Glu Gly Thr  Ser Val Ser 
    3065                 3070                 3075             


Leu Glu  Cys Glu Ser Asn Ala  Val Pro Pro Pro Val  Ile Thr Trp 
    3080                 3085                 3090             


Tyr Lys  Asn Gly Arg Met Ile  Thr Glu Ser Thr His  Val Glu Ile 
    3095                 3100                 3105             


Leu Ala  Asp Gly Gln Met Leu  His Ile Lys Lys Ala  Glu Val Ser 
    3110                 3115                 3120             


Asp Thr  Gly Gln Tyr Val Cys  Arg Ala Ile Asn Val  Ala Gly Arg 
    3125                 3130                 3135             


Asp Asp  Lys Asn Phe His Leu  Asn Val Tyr Val Pro  Pro Ser Ile 
    3140                 3145                 3150             


Glu Gly  Pro Glu Arg Glu Val  Ile Val Glu Thr Ile  Ser Asn Pro 
    3155                 3160                 3165             


Val Thr  Leu Thr Cys Asp Ala  Thr Gly Ile Pro Pro  Pro Thr Ile 
    3170                 3175                 3180             


Ala Trp  Leu Lys Asn His Lys  Arg Ile Glu Asn Ser  Asp Ser Leu 
    3185                 3190                 3195             


Glu Val  Arg Ile Leu Ser Gly  Gly Ser Lys Leu Gln  Ile Ala Arg 
    3200                 3205                 3210             


Ser Gln  His Ser Asp Ser Gly  Asn Tyr Thr Cys Ile  Ala Ser Asn 
    3215                 3220                 3225             


Met Glu  Gly Lys Ala Gln Lys  Tyr Tyr Phe Leu Ser  Ile Gln Val 
    3230                 3235                 3240             


Pro Pro  Ser Val Ala Gly Ala  Glu Ile Pro Ser Asp  Val Ser Val 
    3245                 3250                 3255             


Leu Leu  Gly Glu Asn Val Glu  Leu Val Cys Asn Ala  Asn Gly Ile 
    3260                 3265                 3270             


Pro Thr  Pro Leu Ile Gln Trp  Leu Lys Asp Gly Lys  Pro Ile Ala 
    3275                 3280                 3285             


Ser Gly  Glu Thr Glu Arg Ile  Arg Val Ser Ala Asn  Gly Ser Thr 
    3290                 3295                 3300             


Leu Asn  Ile Tyr Gly Ala Leu  Thr Ser Asp Thr Gly  Lys Tyr Thr 
    3305                 3310                 3315             


Cys Val  Ala Thr Asn Pro Ala  Gly Glu Glu Asp Arg  Ile Phe Asn 
    3320                 3325                 3330             


Leu Asn  Val Tyr Val Thr Pro  Thr Ile Arg Gly Asn  Lys Asp Glu 
    3335                 3340                 3345             


Ala Glu  Lys Leu Met Thr Leu  Val Asp Thr Ser Ile  Asn Ile Glu 
    3350                 3355                 3360             


Cys Arg  Ala Thr Gly Thr Pro  Pro Pro Gln Ile Asn  Trp Leu Lys 
    3365                 3370                 3375             


Asn Gly  Leu Pro Leu Pro Leu  Ser Ser His Ile Arg  Leu Leu Ala 
    3380                 3385                 3390             


Ala Gly  Gln Val Ile Arg Ile  Val Arg Ala Gln Val  Ser Asp Val 
    3395                 3400                 3405             


Ala Val  Tyr Thr Cys Val Ala  Ser Asn Arg Ala Gly  Val Asp Asn 
    3410                 3415                 3420             


Lys His  Tyr Asn Leu Gln Val  Phe Ala Pro Pro Asn  Met Asp Asn 
    3425                 3430                 3435             


Ser Met  Gly Thr Glu Glu Ile  Thr Val Leu Lys Gly  Ser Ser Thr 
    3440                 3445                 3450             


Ser Met  Ala Cys Ile Thr Asp  Gly Thr Pro Ala Pro  Ser Met Ala 
    3455                 3460                 3465             


Trp Leu  Arg Asp Gly Gln Pro  Leu Gly Leu Asp Ala  His Leu Thr 
    3470                 3475                 3480             


Val Ser  Thr His Gly Met Val  Leu Gln Leu Leu Lys  Ala Glu Thr 
    3485                 3490                 3495             


Glu Asp  Ser Gly Lys Tyr Thr  Cys Ile Ala Ser Asn  Glu Ala Gly 
    3500                 3505                 3510             


Glu Val  Ser Lys His Phe Ile  Leu Lys Val Leu Glu  Pro Pro His 
    3515                 3520                 3525             


Ile Asn  Gly Ser Glu Glu His  Glu Glu Ile Ser Val  Ile Val Asn 
    3530                 3535                 3540             


Asn Pro  Leu Glu Leu Thr Cys  Ile Ala Ser Gly Ile  Pro Ala Pro 
    3545                 3550                 3555             


Lys Met  Thr Trp Met Lys Asp  Gly Arg Pro Leu Pro  Gln Thr Asp 
    3560                 3565                 3570             


Gln Val  Gln Thr Leu Gly Gly  Gly Glu Val Leu Arg  Ile Ser Thr 
    3575                 3580                 3585             


Ala Gln  Val Glu Asp Thr Gly  Arg Tyr Thr Cys Leu  Ala Ser Ser 
    3590                 3595                 3600             


Pro Ala  Gly Asp Asp Asp Lys  Glu Tyr Leu Val Arg  Val His Val 
    3605                 3610                 3615             


Pro Pro  Asn Ile Ala Gly Thr  Asp Glu Pro Arg Asp  Ile Thr Val 
    3620                 3625                 3630             


Leu Arg  Asn Arg Gln Val Thr  Leu Glu Cys Lys Ser  Asp Ala Val 
    3635                 3640                 3645             


Pro Pro  Pro Val Ile Thr Trp  Leu Arg Asn Gly Glu  Arg Leu Gln 
    3650                 3655                 3660             


Ala Thr  Pro Arg Val Arg Ile  Leu Ser Gly Gly Arg  Tyr Leu Gln 
    3665                 3670                 3675             


Ile Asn  Asn Ala Asp Leu Gly  Asp Thr Ala Asn Tyr  Thr Cys Val 
    3680                 3685                 3690             


Ala Ser  Asn Ile Ala Gly Lys  Thr Thr Arg Glu Phe  Ile Leu Thr 
    3695                 3700                 3705             


Val Asn  Val Pro Pro Asn Ile  Lys Gly Gly Pro Gln  Ser Leu Val 
    3710                 3715                 3720             


Ile Leu  Leu Asn Lys Ser Thr  Val Leu Glu Cys Ile  Ala Glu Gly 
    3725                 3730                 3735             


Val Pro  Thr Pro Arg Ile Thr  Trp Arg Lys Asp Gly  Ala Val Leu 
    3740                 3745                 3750             


Ala Gly  Asn His Ala Arg Tyr  Ser Ile Leu Glu Asn  Gly Phe Leu 
    3755                 3760                 3765             


His Ile  Gln Ser Ala His Val  Thr Asp Thr Gly Arg  Tyr Leu Cys 
    3770                 3775                 3780             


Met Ala  Thr Asn Ala Ala Gly  Thr Asp Arg Arg Arg  Ile Asp Leu 
    3785                 3790                 3795             


Gln Val  His Val Pro Pro Ser  Ile Ala Pro Gly Pro  Thr Asn Met 
    3800                 3805                 3810             


Thr Val  Ile Val Asn Val Gln  Thr Thr Leu Ala Cys  Glu Ala Thr 
    3815                 3820                 3825             


Gly Ile  Pro Lys Pro Ser Ile  Asn Trp Arg Lys Asn  Gly His Leu 
    3830                 3835                 3840             


Leu Asn  Val Asp Gln Asn Gln  Asn Ser Tyr Arg Leu  Leu Ser Ser 
    3845                 3850                 3855             


Gly Ser  Leu Val Ile Ile Ser  Pro Ser Val Asp Asp  Thr Ala Thr 
    3860                 3865                 3870             


Tyr Glu  Cys Thr Val Thr Asn  Gly Ala Gly Asp Asp  Lys Arg Thr 
    3875                 3880                 3885             


Val Asp  Leu Thr Val Gln Val  Pro Pro Ser Ile Ala  Asp Glu Pro 
    3890                 3895                 3900             


Thr Asp  Phe Leu Val Thr Lys  His Ala Pro Ala Val  Ile Thr Cys 
    3905                 3910                 3915             


Thr Ala  Ser Gly Val Pro Phe  Pro Ser Ile His Trp  Thr Lys Asn 
    3920                 3925                 3930             


Gly Ile  Arg Leu Leu Pro Arg  Gly Asp Gly Tyr Arg  Ile Leu Ser 
    3935                 3940                 3945             


Ser Gly  Ala Ile Glu Ile Leu  Ala Thr Gln Leu Asn  His Ala Gly 
    3950                 3955                 3960             


Arg Tyr  Thr Cys Val Ala Arg  Asn Ala Ala Gly Ser  Ala His Arg 
    3965                 3970                 3975             


His Val  Thr Leu His Val His  Glu Pro Pro Val Ile  Gln Pro Gln 
    3980                 3985                 3990             


Pro Ser  Glu Leu His Val Ile  Leu Asn Asn Pro Ile  Leu Leu Pro 
    3995                 4000                 4005             


Cys Glu  Ala Thr Gly Thr Pro  Ser Pro Phe Ile Thr  Trp Gln Lys 
    4010                 4015                 4020             


Glu Gly  Ile Asn Val Asn Thr  Ser Gly Arg Asn His  Ala Val Leu 
    4025                 4030                 4035             


Pro Ser  Gly Gly Leu Gln Ile  Ser Arg Ala Val Arg  Glu Asp Ala 
    4040                 4045                 4050             


Gly Thr  Tyr Met Cys Val Ala  Gln Asn Pro Ala Gly  Thr Ala Leu 
    4055                 4060                 4065             


Gly Lys  Ile Lys Leu Asn Val  Gln Val Pro Pro Val  Ile Ser Pro 
    4070                 4075                 4080             


His Leu  Lys Glu Tyr Val Ile  Ala Val Asp Lys Pro  Ile Thr Leu 
    4085                 4090                 4095             


Ser Cys  Glu Ala Asp Gly Leu  Pro Pro Pro Asp Ile  Thr Trp His 
    4100                 4105                 4110             


Lys Asp  Gly Arg Ala Ile Val  Glu Ser Ile Arg Gln  Arg Val Leu 
    4115                 4120                 4125             


Ser Ser  Gly Ser Leu Gln Ile  Ala Phe Val Gln Pro  Gly Asp Ala 
    4130                 4135                 4140             


Gly His  Tyr Thr Cys Met Ala  Ala Asn Val Ala Gly  Ser Ser Ser 
    4145                 4150                 4155             


Thr Ser  Thr Lys Leu Thr Val  His Val Pro Pro Arg  Ile Arg Ser 
    4160                 4165                 4170             


Thr Glu  Gly His Tyr Thr Val  Asn Glu Asn Ser Gln  Ala Ile Leu 
    4175                 4180                 4185             


Pro Cys  Val Ala Asp Gly Ile  Pro Thr Pro Ala Ile  Asn Trp Lys 
    4190                 4195                 4200             


Lys Asp  Asn Val Leu Leu Ala  Asn Leu Leu Gly Lys  Tyr Thr Ala 
    4205                 4210                 4215             


Glu Pro  Tyr Gly Glu Leu Ile  Leu Glu Asn Val Val  Leu Glu Asp 
    4220                 4225                 4230             


Ser Gly  Phe Tyr Thr Cys Val  Ala Asn Asn Ala Ala  Gly Glu Asp 
    4235                 4240                 4245             


Thr His  Thr Val Ser Leu Thr  Val His Val Leu Pro  Thr Phe Thr 
    4250                 4255                 4260             


Glu Leu  Pro Gly Asp Val Ser  Leu Asn Lys Gly Glu  Gln Leu Arg 
    4265                 4270                 4275             


Leu Ser  Cys Lys Ala Thr Gly  Ile Pro Leu Pro Lys  Leu Thr Trp 
    4280                 4285                 4290             


Thr Phe  Asn Asn Asn Ile Ile  Pro Ala His Phe Asp  Ser Val Asn 
    4295                 4300                 4305             


Gly His  Ser Glu Leu Val Ile  Glu Arg Val Ser Lys  Glu Asp Ser 
    4310                 4315                 4320             


Gly Thr  Tyr Val Cys Thr Ala  Glu Asn Ser Val Gly  Phe Val Lys 
    4325                 4330                 4335             


Ala Ile  Gly Phe Val Tyr Val  Lys Glu Pro Pro Val  Phe Lys Gly 
    4340                 4345                 4350             


Asp Tyr  Pro Ser Asn Trp Ile  Glu Pro Leu Gly Gly  Asn Ala Ile 
    4355                 4360                 4365             


Leu Asn  Cys Glu Val Lys Gly  Asp Pro Thr Pro Thr  Ile Gln Trp 
    4370                 4375                 4380             


Asn Arg  Lys Gly Val Asp Ile  Glu Ile Ser His Arg  Ile Arg Gln 
    4385                 4390                 4395             


Leu Gly  Asn Gly Ser Leu Ala  Ile Tyr Gly Thr Val  Asn Glu Asp 
    4400                 4405                 4410             


Ala Gly  Asp Tyr Thr Cys Val  Ala Thr Asn Glu Ala  Gly Val Val 
    4415                 4420                 4425             


Glu Arg  Ser Met Ser Leu Thr  Leu Gln Ser Pro Pro  Ile Ile Thr 
    4430                 4435                 4440             


Leu Glu  Pro Val Glu Thr Val  Ile Asn Ala Gly Gly  Lys Ile Ile 
    4445                 4450                 4455             


Leu Asn  Cys Gln Ala Thr Gly  Glu Pro Gln Pro Thr  Ile Thr Trp 
    4460                 4465                 4470             


Ser Arg  Gln Gly His Ser Ile  Ser Trp Asp Asp Arg  Val Asn Val 
    4475                 4480                 4485             


Leu Ser  Asn Asn Ser Leu Tyr  Ile Ala Asp Ala Gln  Lys Glu Asp 
    4490                 4495                 4500             


Thr Ser  Glu Phe Glu Cys Val  Ala Arg Asn Leu Met  Gly Ser Val 
    4505                 4510                 4515             


Leu Val  Arg Val Pro Val Ile  Val Gln Val His Gly  Gly Phe Ser 
    4520                 4525                 4530             


Gln Trp  Ser Ala Trp Arg Ala  Cys Ser Val Thr Cys  Gly Lys Gly 
    4535                 4540                 4545             


Ile Gln  Lys Arg Ser Arg Leu  Cys Asn Gln Pro Leu  Pro Ala Asn 
    4550                 4555                 4560             


Gly Gly  Lys Pro Cys Gln Gly  Ser Asp Leu Glu Met  Arg Asn Cys 
    4565                 4570                 4575             


Gln Asn  Lys Pro Cys Pro Val  Asp Gly Ser Trp Ser  Glu Trp Ser 
    4580                 4585                 4590             


Leu Trp  Glu Glu Cys Thr Arg  Ser Cys Gly Arg Gly  Asn Gln Thr 
    4595                 4600                 4605             


Arg Thr  Arg Thr Cys Asn Asn  Pro Ser Val Gln His  Gly Gly Arg 
    4610                 4615                 4620             


Pro Cys  Glu Gly Asn Ala Val  Glu Ile Ile Met Cys  Asn Ile Arg 
    4625                 4630                 4635             


Pro Cys  Pro Val His Gly Ala  Trp Ser Ala Trp Gln  Pro Trp Gly 
    4640                 4645                 4650             


Thr Cys  Ser Glu Ser Cys Gly  Lys Gly Thr Gln Thr  Arg Ala Arg 
    4655                 4660                 4665             


Leu Cys  Asn Asn Pro Pro Pro  Ala Phe Gly Gly Ser  Tyr Cys Asp 
    4670                 4675                 4680             


Gly Ala  Glu Thr Gln Met Gln  Val Cys Asn Glu Arg  Asn Cys Pro 
    4685                 4690                 4695             


Ile His  Gly Lys Trp Ala Thr  Trp Ala Ser Trp Ser  Ala Cys Ser 
    4700                 4705                 4710             


Val Ser  Cys Gly Gly Gly Ala  Arg Gln Arg Thr Arg  Gly Cys Ser 
    4715                 4720                 4725             


Asp Pro  Val Pro Gln Tyr Gly  Gly Arg Lys Cys Glu  Gly Ser Asp 
    4730                 4735                 4740             


Val Gln  Ser Asp Phe Cys Asn  Ser Asp Pro Cys Pro  Thr His Gly 
    4745                 4750                 4755             


Asn Trp  Ser Pro Trp Ser Gly  Trp Gly Thr Cys Ser  Arg Thr Cys 
    4760                 4765                 4770             


Asn Gly  Gly Gln Met Arg Arg  Tyr Arg Thr Cys Asp  Asn Pro Pro 
    4775                 4780                 4785             


Pro Ser  Asn Gly Gly Arg Ala  Cys Gly Gly Pro Asp  Ser Gln Ile 
    4790                 4795                 4800             


Gln Arg  Cys Asn Thr Asp Met  Cys Pro Val Asp Gly  Ser Trp Gly 
    4805                 4810                 4815             


Ser Trp  His Ser Trp Ser Gln  Cys Ser Ala Ser Cys  Gly Gly Gly 
    4820                 4825                 4830             


Glu Lys  Thr Arg Lys Arg Leu  Cys Asp His Pro Val  Pro Val Lys 
    4835                 4840                 4845             


Gly Gly  Arg Pro Cys Pro Gly  Asp Thr Thr Gln Val  Thr Arg Cys 
    4850                 4855                 4860             


Asn Val  Gln Ala Cys Pro Gly  Gly Pro Gln Arg Ala  Arg Gly Ser 
    4865                 4870                 4875             


Val Ile  Gly Asn Ile Asn Asp  Val Glu Phe Gly Ile  Ala Phe Leu 
    4880                 4885                 4890             


Asn Ala  Thr Ile Thr Asp Ser  Pro Asn Ser Asp Thr  Arg Ile Ile 
    4895                 4900                 4905             


Arg Ala  Lys Ile Thr Asn Val  Pro Arg Ser Leu Gly  Ser Ala Met 
    4910                 4915                 4920             


Arg Lys  Ile Val Ser Ile Leu  Asn Pro Ile Tyr Trp  Thr Thr Ala 
    4925                 4930                 4935             


Lys Glu  Ile Gly Glu Ala Val  Asn Gly Phe Thr Leu  Thr Asn Ala 
    4940                 4945                 4950             


Val Phe  Lys Arg Glu Thr Gln  Val Glu Phe Ala Thr  Gly Glu Ile 
    4955                 4960                 4965             


Leu Gln  Met Ser His Ile Ala  Arg Gly Leu Asp Ser  Asp Gly Ser 
    4970                 4975                 4980             


Leu Leu  Leu Asp Ile Val Val  Ser Gly Tyr Val Leu  Gln Leu Gln 
    4985                 4990                 4995             


Ser Pro  Ala Glu Val Thr Val  Lys Asp Tyr Thr Glu  Asp Tyr Ile 
    5000                 5005                 5010             


Gln Thr  Gly Pro Gly Gln Leu  Tyr Ala Tyr Ser Thr  Arg Leu Phe 
    5015                 5020                 5025             


Thr Ile  Asp Gly Ile Ser Ile  Pro Tyr Thr Trp Asn  His Thr Val 
    5030                 5035                 5040             


Phe Tyr  Asp Gln Ala Gln Gly  Arg Met Pro Phe Leu  Val Glu Thr 
    5045                 5050                 5055             


Leu His  Ala Ser Ser Val Glu  Ser Asp Tyr Asn Gln  Ile Glu Glu 
    5060                 5065                 5070             


Thr Leu  Gly Phe Lys Ile His  Ala Ser Ile Ser Lys  Gly Asp Arg 
    5075                 5080                 5085             


Ser Asn  Gln Cys Pro Ser Gly  Phe Thr Leu Asp Ser  Val Gly Pro 
    5090                 5095                 5100             


Phe Cys  Ala Asp Glu Asp Glu  Cys Ala Ala Gly Asn  Pro Cys Ser 
    5105                 5110                 5115             


His Ser  Cys His Asn Ala Met  Gly Thr Tyr Tyr Cys  Ser Cys Pro 
    5120                 5125                 5130             


Lys Gly  Leu Thr Ile Ala Ala  Asp Gly Arg Thr Cys  Gln Asp Ile 
    5135                 5140                 5145             


Asp Glu  Cys Ala Leu Gly Arg  His Thr Cys His Ala  Gly Gln Asp 
    5150                 5155                 5160             


Cys Asp  Asn Thr Ile Gly Ser  Tyr Arg Cys Val Val  Arg Cys Gly 
    5165                 5170                 5175             


Ser Gly  Phe Arg Arg Thr Ser  Asp Gly Leu Ser Cys  Gln Asp Ile 
    5180                 5185                 5190             


Asn Glu  Cys Gln Glu Ser Ser  Pro Cys His Gln Arg  Cys Phe Asn 
    5195                 5200                 5205             


Ala Ile  Gly Ser Phe His Cys  Gly Cys Glu Pro Gly  Tyr Gln Leu 
    5210                 5215                 5220             


Lys Gly  Arg Lys Cys Met Asp  Val Asn Glu Cys Arg  Gln Asn Val 
    5225                 5230                 5235             


Cys Arg  Pro Asp Gln His Cys  Lys Asn Thr Arg Gly  Gly Tyr Lys 
    5240                 5245                 5250             


Cys Ile  Asp Leu Cys Pro Asn  Gly Met Thr Lys Ala  Glu Asn Gly 
    5255                 5260                 5265             


Thr Cys  Ile Asp Ile Asp Glu  Cys Lys Asp Gly Thr  His Gln Cys 
    5270                 5275                 5280             


Arg Tyr  Asn Gln Ile Cys Glu  Asn Thr Arg Gly Ser  Tyr Arg Cys 
    5285                 5290                 5295             


Val Cys  Pro Arg Gly Tyr Arg  Ser Gln Gly Val Gly  Arg Pro Cys 
    5300                 5305                 5310             


Met Asp  Ile Asn Glu Cys Glu  Gln Val Pro Lys Pro  Cys Ala His 
    5315                 5320                 5325             


Gln Cys  Ser Asn Thr Pro Gly  Ser Phe Lys Cys Ile  Cys Pro Pro 
    5330                 5335                 5340             


Gly Gln  His Leu Leu Gly Asp  Gly Lys Ser Cys Ala  Gly Leu Glu 
    5345                 5350                 5355             


Arg Leu  Pro Asn Tyr Gly Thr  Gln Tyr Ser Ser Tyr  Asn Leu Ala 
    5360                 5365                 5370             


Arg Phe  Ser Pro Val Arg Asn  Asn Tyr Gln Pro Gln  Gln His Tyr 
    5375                 5380                 5385             


Arg Gln  Tyr Ser His Leu Tyr  Ser Ser Tyr Ser Glu  Tyr Arg Asn 
    5390                 5395                 5400             


Ser Arg  Thr Ser Leu Ser Arg  Thr Arg Arg Thr Ile  Arg Lys Thr 
    5405                 5410                 5415             


Cys Pro  Glu Gly Ser Glu Ala  Ser His Asp Thr Cys  Val Asp Ile 
    5420                 5425                 5430             


Asp Glu  Cys Glu Asn Thr Asp  Ala Cys Gln His Glu  Cys Lys Asn 
    5435                 5440                 5445             


Thr Phe  Gly Ser Tyr Gln Cys  Ile Cys Pro Pro Gly  Tyr Gln Leu 
    5450                 5455                 5460             


Thr His  Asn Gly Lys Thr Cys  Gln Asp Ile Asp Glu  Cys Leu Glu 
    5465                 5470                 5475             


Gln Asn  Val His Cys Gly Pro  Asn Arg Met Cys Phe  Asn Met Arg 
    5480                 5485                 5490             


Gly Ser  Tyr Gln Cys Ile Asp  Thr Pro Cys Pro Pro  Asn Tyr Gln 
    5495                 5500                 5505             


Arg Asp  Pro Val Ser Gly Phe  Cys Leu Lys Asn Cys  Pro Pro Asn 
    5510                 5515                 5520             


Asp Leu  Glu Cys Ala Leu Ser  Pro Tyr Ala Leu Glu  Tyr Lys Leu 
    5525                 5530                 5535             


Val Ser  Leu Pro Phe Gly Ile  Ala Thr Asn Gln Asp  Leu Ile Arg 
    5540                 5545                 5550             


Leu Val  Ala Tyr Thr Gln Asp  Gly Val Met His Pro  Arg Thr Thr 
    5555                 5560                 5565             


Phe Leu  Met Val Asp Glu Glu  Gln Thr Val Pro Phe  Ala Leu Arg 
    5570                 5575                 5580             


Asp Glu  Asn Leu Lys Gly Val  Val Tyr Thr Thr Arg  Pro Leu Arg 
    5585                 5590                 5595             


Glu Ala  Glu Thr Tyr Arg Met  Arg Val Arg Ala Ser  Ser Tyr Ser 
    5600                 5605                 5610             


Ala Asn  Gly Thr Ile Glu Tyr  Gln Thr Thr Phe Ile  Val Tyr Ile 
    5615                 5620                 5625             


Ala Val  Ser Ala Tyr Pro Tyr  
    5630                 5635 


<210>  6521
<211>  595
<212>  PRT
<213>  Homo Sapiens

<400>  6521

Met Ile Leu Ala Pro Glu Gly Ser Ser Ser Gly Lys Leu Arg Ile Pro 
1               5                   10                  15      


Ala Ala Gln Glu Arg Asp Ala Gly Thr Tyr Thr Cys Arg Ala Val Asn 
            20                  25                  30          


Glu Leu Gly Asp Ala Ser Ala Glu Ile Gln Leu Ala Val Gly His Ala 
        35                  40                  45              


Pro Gln Leu Thr Glu Leu Pro Arg Asp Val Thr Val Glu Leu Gly Arg 
    50                  55                  60                  


Ser Ala Leu Leu Ala Cys Arg Ala Thr Gly Arg Pro Pro Pro Thr Val 
65                  70                  75                  80  


Thr Trp Arg Arg Gly Asp Gly Gln Pro Leu Gly Leu Arg Leu Gly Ala 
                85                  90                  95      


Gly Arg Gly Ser Arg Ser Arg Gln Pro Asp Ser Gly Val Leu Phe Phe 
            100                 105                 110         


Glu Ser Val Ala Pro Glu Asp Gln Ala Pro Tyr Val Cys Glu Ala Arg 
        115                 120                 125             


Asn Val Phe Gly Lys Val Gln Ala Glu Ala Arg Leu Ile Val Thr Gly 
    130                 135                 140                 


His Ala Pro Pro Gln Ile Ala Ser Ser Ala Pro Thr Val Arg Val Leu 
145                 150                 155                 160 


Glu Gly Gln Pro Val Ser Leu Pro Cys Ile Val Leu Ala Gly Arg Pro 
                165                 170                 175     


Leu Pro Glu Arg His Trp Leu Lys Asp Gly Arg Pro Leu Pro Pro Gly 
            180                 185                 190         


Ser Arg His Ser Ile Arg Ala Asp Gly Ser Leu His Leu Asp Arg Ala 
        195                 200                 205             


Leu Gln Glu His Ala Gly Arg Tyr Ser Cys Val Ala Thr Asn Thr Ala 
    210                 215                 220                 


Gly Ser Gln His Arg Asp Val Glu Leu Val Val Gln Val Pro Pro Arg 
225                 230                 235                 240 


Ile His Pro Thr Ala Thr His His Ile Thr Asn Glu Gly Val Ala Ala 
                245                 250                 255     


Ser Leu Pro Cys Val Ala Ser Gly Val Pro Ala Pro Thr Ile Thr Trp 
            260                 265                 270         


Thr Lys Glu Thr Asn Ala Leu Thr Ser Arg Gly Pro His Tyr Asn Val 
        275                 280                 285             


Ser Lys Glu Gly Thr Leu Leu Ile Ala Gln Pro Ser Ala Gln Asp Ala 
    290                 295                 300                 


Gly Ala Tyr Val Cys Thr Ala Thr Asn Thr Val Gly Phe Ser Ser Gln 
305                 310                 315                 320 


Glu Met Arg Leu Ser Val Asn Thr Lys Pro Arg Ile His Met Asn Gly 
                325                 330                 335     


Ser Arg Asn Ala Asp Val Pro Leu Gln Val Thr Ala Lys Ala Gly Glu 
            340                 345                 350         


Glu Val Thr Leu Asp Cys Glu Ala Lys Gly Ser Pro Pro Pro Leu Val 
        355                 360                 365             


Thr Trp Thr Lys Asp Ser Arg Pro Val Pro Pro Ile Thr Asn Arg Tyr 
    370                 375                 380                 


Gly Leu Leu Pro Ser Gly Ser Leu Arg Leu Ala Gln Val Gln Val Gly 
385                 390                 395                 400 


Asp Ser Gly His Tyr Glu Cys Thr Ala Ser Asn Pro Ala Gly Ser Ala 
                405                 410                 415     


Ser His Arg Tyr Val Leu Gly Val Gln Gly Arg Thr Ser Trp Gln Pro 
            420                 425                 430         


Gln Ser Leu Pro Val Pro His His Pro Ala Cys Leu Ser Gly Leu Ser 
        435                 440                 445             


Val Pro Leu Leu Gln Pro Thr Pro Arg Ser Val Arg Leu Cys His Leu 
    450                 455                 460                 


Ser Leu Arg Ala Pro Leu Pro Pro Pro Phe Ala Thr Pro Thr Ser Cys 
465                 470                 475                 480 


Leu Ser Gln Ala Cys Leu Ser Ser Ser Thr Leu Ser Leu His Leu Ser 
                485                 490                 495     


Pro Tyr Pro Leu Arg Gly Pro Gly Asp Ala Val Gln Arg Pro Pro Thr 
            500                 505                 510         


Thr Gln Gly Arg Ala Gln Trp Gly Leu Gly Phe Gly Arg Thr Gly Val 
        515                 520                 525             


Arg Gly Glu Pro Met Lys Val Gly Leu Arg Gly Ser Leu Pro Gly Thr 
    530                 535                 540                 


Arg Gly Pro Ala Gly Ser Pro Gly Cys Gly Asp Gly Lys Arg Pro Val 
545                 550                 555                 560 


Arg Cys His Arg Ala Pro Pro Ala Gly Ser Ile Leu Met Pro Pro Arg 
                565                 570                 575     


Gly Pro Ser Glu Pro Leu Leu Pro Pro Leu Pro Ser Thr Arg His Phe 
            580                 585                 590         


Val His Leu 
        595 


<210>  6522
<211>  5059
<212>  PRT
<213>  Homo Sapiens

<400>  6522

Met Pro Gly Ala Pro Leu Leu Arg Leu Leu Thr Ala Val Ser Ala Ala 
1               5                   10                  15      


Val Ala Val Ala Val Ala Gly Ala Pro Gly Thr Val Met Pro Pro Thr 
            20                  25                  30          


Thr Gly Asp Ala Thr Leu Ala Phe Val Phe Asp Val Thr Gly Ser Met 
        35                  40                  45              


Trp Asp Glu Leu Met Gln Val Ile Asp Gly Ala Ser Arg Ile Leu Glu 
    50                  55                  60                  


Arg Ser Leu Ser Arg Arg Ser Gln Ala Ile Ala Asn Tyr Ala Leu Val 
65                  70                  75                  80  


Pro Phe His Asp Pro Asp Ile Gly Pro Val Thr Leu Thr Ala Asp Pro 
                85                  90                  95      


Thr Val Phe Gln Arg Glu Leu Arg Glu Leu Tyr Val Gln Gly Gly Gly 
            100                 105                 110         


Asp Cys Pro Glu Met Ser Val Gly Ala Ile Lys Ala Ala Val Glu Val 
        115                 120                 125             


Ala Asn Pro Gly Ser Phe Ile Tyr Val Phe Ser Asp Ala Arg Ala Lys 
    130                 135                 140                 


Asp Tyr His Lys Lys Glu Glu Leu Leu Arg Leu Leu Gln Leu Lys Gln 
145                 150                 155                 160 


Ser Gln Val Val Phe Val Leu Thr Gly Asp Cys Gly Asp Arg Thr His 
                165                 170                 175     


Pro Gly Tyr Leu Ala Tyr Glu Glu Ile Ala Ala Thr Ser Ser Gly Gln 
            180                 185                 190         


Val Phe His Leu Asp Lys Gln Gln Val Thr Glu Val Leu Lys Trp Val 
        195                 200                 205             


Glu Ser Ala Ile Gln Ala Ser Lys Val His Leu Leu Ser Thr Asp His 
    210                 215                 220                 


Glu Glu Glu Gly Glu His Thr Trp Arg Leu Pro Phe Asp Pro Ser Leu 
225                 230                 235                 240 


Lys Glu Val Thr Ile Ser Leu Ser Gly Pro Gly Pro Glu Ile Glu Val 
                245                 250                 255     


Gln Asp Pro Leu Gly Arg Ile Leu Gln Glu Asp Glu Gly Leu Asn Val 
            260                 265                 270         


Leu Leu Asn Ile Pro Asp Ser Ala Lys Val Val Ala Phe Lys Pro Glu 
        275                 280                 285             


His Pro Gly Leu Trp Ser Ile Lys Val Tyr Ser Ser Gly Arg His Ser 
    290                 295                 300                 


Val Arg Ile Thr Gly Val Ser Asn Ile Asp Phe Arg Ala Gly Phe Ser 
305                 310                 315                 320 


Thr Gln Pro Leu Leu Asp Leu Asn His Thr Leu Glu Trp Pro Leu Gln 
                325                 330                 335     


Gly Val Pro Ile Ser Leu Val Ile Asn Ser Thr Gly Leu Lys Ala Pro 
            340                 345                 350         


Gly Arg Leu Asp Ser Val Glu Leu Ala Gln Ser Ser Gly Lys Pro Leu 
        355                 360                 365             


Leu Thr Leu Pro Thr Lys Pro Leu Ser Asn Gly Ser Thr His Gln Leu 
    370                 375                 380                 


Trp Gly Gly Pro Pro Phe His Thr Pro Lys Glu Arg Phe Tyr Leu Lys 
385                 390                 395                 400 


Val Lys Gly Lys Asp His Glu Gly Asn Pro Leu Leu Arg Val Ser Gly 
                405                 410                 415     


Val Ser Tyr Ser Gly Val Ala Pro Gly Ala Pro Leu Val Ser Met Ala 
            420                 425                 430         


Pro Arg Ile His Gly Tyr Leu His Gln Pro Leu Leu Val Ser Cys Ser 
        435                 440                 445             


Val His Ser Ala Leu Pro Phe Arg Leu Gln Leu Arg Arg Gly Glu Ala 
    450                 455                 460                 


Arg Leu Gly Glu Glu Arg His Phe Gln Glu Ser Gly Asn Ser Ser Trp 
465                 470                 475                 480 


Glu Ile Leu Arg Ala Ser Lys Ala Glu Glu Gly Thr Tyr Glu Cys Thr 
                485                 490                 495     


Ala Val Ser Arg Ala Gly Thr Gly Arg Ala Lys Ala Gln Ile Val Val 
            500                 505                 510         


Thr Asp Pro Pro Pro Gln Leu Val Pro Ala Pro Asn Val Thr Val Ser 
        515                 520                 525             


Pro Gly Glu Thr Ala Val Leu Ser Cys Arg Val Leu Gly Glu Ala Pro 
    530                 535                 540                 


Tyr Asn Leu Thr Trp Val Arg Asp Trp Arg Val Leu Pro Ala Ser Thr 
545                 550                 555                 560 


Gly Arg Val Ala Gln Leu Ala Asp Leu Ser Leu Glu Ile Ser Gly Ile 
                565                 570                 575     


Ile Pro Thr Asp Gly Gly Arg Tyr Gln Cys Val Ala Ser Asn Ala Asn 
            580                 585                 590         


Gly Val Thr Arg Ala Ser Val Trp Leu Leu Val Arg Glu Ala Pro Gln 
        595                 600                 605             


Val Ser Ile His Thr Ser Ser Gln His Phe Ser Gln Gly Val Glu Val 
    610                 615                 620                 


Lys Val Ser Cys Ser Ala Ser Gly Tyr Pro Thr Pro His Ile Ser Trp 
625                 630                 635                 640 


Ser Arg Glu Ser Gln Ala Leu Gln Glu Asp Ser Arg Ile His Val Asp 
                645                 650                 655     


Ala Gln Gly Thr Leu Ile Ile Gln Gly Val Ala Pro Glu Asp Ala Gly 
            660                 665                 670         


Asn Tyr Ser Cys Gln Ala Thr Asn Glu Val Gly Thr Asp Gln Glu Thr 
        675                 680                 685             


Val Thr Leu Tyr Tyr Thr Asp Pro Pro Ser Val Ser Ala Val Asn Ala 
    690                 695                 700                 


Val Val Leu Val Ala Val Gly Glu Glu Ala Val Leu Val Cys Glu Ala 
705                 710                 715                 720 


Ser Gly Val Pro Pro Pro Arg Val Ile Trp Tyr Arg Gly Gly Leu Glu 
                725                 730                 735     


Met Ile Leu Ala Pro Glu Gly Ser Ser Ser Gly Lys Leu Arg Ile Pro 
            740                 745                 750         


Ala Ala Gln Glu Arg Asp Ala Gly Thr Tyr Thr Cys Arg Ala Val Asn 
        755                 760                 765             


Glu Leu Gly Asp Ala Ser Ala Glu Ile Gln Leu Ala Val Gly His Ala 
    770                 775                 780                 


Pro Gln Leu Thr Glu Leu Pro Arg Asp Val Thr Val Glu Leu Gly Arg 
785                 790                 795                 800 


Ser Ala Leu Leu Ala Cys Arg Ala Thr Gly Arg Pro Pro Pro Thr Val 
                805                 810                 815     


Thr Trp Arg Arg Gly Asp Gly Gln Pro Leu Gly Leu Arg Leu Gly Ala 
            820                 825                 830         


Gly Arg Gly Ser Arg Ser Arg Gln Pro Asp Ser Gly Val Leu Phe Phe 
        835                 840                 845             


Glu Ser Val Ala Pro Glu Asp Gln Ala Pro Tyr Val Cys Glu Ala Arg 
    850                 855                 860                 


Asn Val Phe Gly Lys Val Gln Ala Glu Ala Arg Leu Ile Val Thr Gly 
865                 870                 875                 880 


His Ala Pro Pro Gln Ile Ala Ser Ser Ala Pro Thr Val Arg Val Leu 
                885                 890                 895     


Glu Gly Gln Pro Val Ser Leu Pro Cys Ile Val Leu Ala Gly Arg Pro 
            900                 905                 910         


Leu Pro Glu Arg His Trp Leu Lys Asp Gly Arg Pro Leu Pro Pro Gly 
        915                 920                 925             


Ser Arg His Ser Ile Arg Ala Asp Gly Ser Leu His Leu Asp Arg Ala 
    930                 935                 940                 


Leu Gln Glu His Ala Gly Arg Tyr Ser Cys Val Ala Thr Asn Thr Ala 
945                 950                 955                 960 


Gly Ser Gln His Arg Asp Val Glu Leu Val Val Gln Val Pro Pro Arg 
                965                 970                 975     


Ile His Pro Thr Ala Thr His His Ile Thr Asn Glu Gly Val Ala Ala 
            980                 985                 990         


Ser Leu Pro Cys Val Ala Ser Gly  Val Pro Ala Pro Thr  Ile Thr Trp 
        995                 1000                 1005             


Thr Lys  Glu Thr Asn Ala Leu  Thr Ser Arg Gly Pro  His Tyr Asn 
    1010                 1015                 1020             


Val Ser  Lys Glu Gly Thr Leu  Leu Ile Ala Gln Pro  Ser Ala Gln 
    1025                 1030                 1035             


Asp Ala  Gly Ala Tyr Val Cys  Thr Ala Thr Asn Thr  Val Gly Phe 
    1040                 1045                 1050             


Ser Ser  Gln Glu Met Arg Leu  Ser Val Asn Thr Lys  Pro Arg Ile 
    1055                 1060                 1065             


His Met  Asn Gly Ser Arg Asn  Ala Asp Val Pro Leu  Gln Val Thr 
    1070                 1075                 1080             


Ala Lys  Ala Gly Glu Glu Val  Thr Leu Asp Cys Glu  Ala Lys Gly 
    1085                 1090                 1095             


Ser Pro  Pro Pro Leu Val Thr  Trp Thr Lys Asp Ser  Arg Pro Val 
    1100                 1105                 1110             


Pro Pro  Ile Thr Asn Arg Tyr  Gly Leu Leu Pro Ser  Gly Ser Leu 
    1115                 1120                 1125             


Arg Leu  Ala Gln Val Gln Val  Gly Asp Ser Gly His  Tyr Glu Cys 
    1130                 1135                 1140             


Thr Ala  Ser Asn Pro Ala Gly  Ser Ala Ser His Arg  Tyr Val Leu 
    1145                 1150                 1155             


Gly Val  Gln Val Pro Pro Gln  Val Gln Pro Gly Pro  Arg Val Leu 
    1160                 1165                 1170             


Lys Val  Leu Val Gly Glu Ala  Leu Asp Leu Asn Cys  Val Ala Glu 
    1175                 1180                 1185             


Gly Asn  Pro Glu Pro Gln Leu  Ser Trp Ser Lys Asp  Gly Val Val 
    1190                 1195                 1200             


Leu Gln  Gly Arg Gly Pro Gln  Gly Ser Val His Phe  Ala Ala Ile 
    1205                 1210                 1215             


Arg Thr  Ser Asp Ala Gly Arg  Tyr Arg Cys Glu Ala  Ser Asn Ser 
    1220                 1225                 1230             


Ala Gly  Val Asp Ala Trp Glu  Val Glu Leu Arg Val  Leu Glu Pro 
    1235                 1240                 1245             


Pro His  Trp Gly Ala Asp Glu  Thr Ser Gly Leu Leu  Glu Arg Val 
    1250                 1255                 1260             


Ala Gly  Glu Asn Ala Ser Leu  Pro Cys Pro Ala Arg  Gly Thr Pro 
    1265                 1270                 1275             


Lys Pro  Gln Val Thr Trp Arg  Lys Gly Pro Ser Ser  Glu Pro Leu 
    1280                 1285                 1290             


His Gly  Gln Pro Gly Val Ala  Val Leu Glu Glu Gly  Ser Leu Phe 
    1295                 1300                 1305             


Leu Ala  Ser Val Ser Pro Ala  Asp Ser Gly Asp Tyr  Glu Cys Gln 
    1310                 1315                 1320             


Ala Thr  Asn Glu Val Gly Ser  Thr Ser Arg Arg Ala  Lys Leu Val 
    1325                 1330                 1335             


Val Tyr  Val Pro Pro Ser Ile  Arg Glu Asp Gly Arg  Lys Ala Asn 
    1340                 1345                 1350             


Val Ser  Gly Met Ala Gly Gln  Ser Leu Thr Leu Glu  Cys Asp Ala 
    1355                 1360                 1365             


Asn Gly  Phe Pro Val Pro Glu  Ile Val Trp Leu Lys  Asp Ala Gln 
    1370                 1375                 1380             


Leu Ile  Pro Lys Val Gly Gly  His Arg Leu Leu Asp  Glu Gly Gln 
    1385                 1390                 1395             


Ser Leu  His Phe Pro Arg Ile  Gln Glu Gly Asp Ser  Gly Leu Tyr 
    1400                 1405                 1410             


Ser Cys  Arg Ala Glu Asn Gln  Ala Gly Thr Ala Gln  Arg Asp Phe 
    1415                 1420                 1425             


His Leu  Leu Val Leu Thr Pro  Pro Ser Val Leu Gly  Ala Gly Ala 
    1430                 1435                 1440             


Ala Gln  Glu Val Leu Gly Leu  Ala Gly Ala Asp Val  Glu Leu Gln 
    1445                 1450                 1455             


Cys Trp  Thr Ser Gly Val Pro  Thr Pro Gln Val Glu  Trp Thr Lys 
    1460                 1465                 1470             


Asp Arg  Gln Pro Val Leu Pro  Gly Gly Pro His Leu  Gln Val Gln 
    1475                 1480                 1485             


Glu Asp  Gly Gln Val Leu Arg  Ile Thr Gly Ser His  Val Gly Asp 
    1490                 1495                 1500             


Glu Gly  Arg Tyr Gln Cys Val  Ala Phe Ser Pro Ala  Gly Gln Gln 
    1505                 1510                 1515             


Ala Arg  Asp Phe Gln Leu Arg  Val His Ala Pro Pro  Thr Ile Trp 
    1520                 1525                 1530             


Gly Ser  Asn Glu Thr Gly Glu  Val Ala Val Met Glu  Asp His Leu 
    1535                 1540                 1545             


Val Gln  Leu Leu Cys Glu Ala  Arg Gly Val Pro Thr  Pro Asn Ile 
    1550                 1555                 1560             


Thr Trp  Phe Lys Asp Gly Ala  Leu Leu Pro Thr Ser  Thr Lys Val 
    1565                 1570                 1575             


Val Tyr  Thr Arg Gly Gly Arg  Gln Leu Gln Leu Gly  Arg Ala Gln 
    1580                 1585                 1590             


Ser Ser  Asp Ala Gly Val Tyr  Thr Cys Lys Ala Ser  Asn Ala Val 
    1595                 1600                 1605             


Gly Ala  Ala Glu Lys Ala Thr  Arg Leu Asp Val Tyr  Val Pro Pro 
    1610                 1615                 1620             


Thr Ile  Glu Gly Ala Gly Gly  Arg Pro Tyr Val Val  Lys Ala Val 
    1625                 1630                 1635             


Ala Gly  Arg Pro Val Ala Leu  Glu Cys Val Ala Arg  Gly His Pro 
    1640                 1645                 1650             


Ser Pro  Thr Leu Ser Trp His  His Glu Gly Leu Pro  Val Ala Glu 
    1655                 1660                 1665             


Ser Asn  Glu Ser Arg Leu Glu  Thr Asp Gly Ser Val  Leu Arg Leu 
    1670                 1675                 1680             


Glu Ser  Pro Gly Glu Ala Ser  Ser Gly Leu Tyr Ser  Cys Val Ala 
    1685                 1690                 1695             


Ser Ser  Pro Ala Gly Glu Ala  Val Leu Gln Tyr Ser  Val Glu Val 
    1700                 1705                 1710             


Gln Val  Pro Pro Gln Leu Leu  Val Ala Glu Gly Leu  Gly Gln Val 
    1715                 1720                 1725             


Thr Thr  Ile Val Gly Gln Pro  Leu Glu Leu Pro Cys  Gln Ala Ser 
    1730                 1735                 1740             


Gly Ser  Pro Val Pro Thr Ile  Gln Trp Leu Gln Asn  Gly Arg Pro 
    1745                 1750                 1755             


Ala Glu  Glu Leu Ala Gly Val  Gln Val Ala Ser Gln  Gly Thr Thr 
    1760                 1765                 1770             


Leu His  Ile Asp His Val Glu  Leu Asp His Ser Gly  Leu Phe Ala 
    1775                 1780                 1785             


Cys Gln  Ala Thr Asn Glu Ala  Gly Thr Ala Gly Ala  Glu Val Glu 
    1790                 1795                 1800             


Val Ser  Val His Glu Phe Pro  Ser Val Ser Ile Ile  Gly Gly Glu 
    1805                 1810                 1815             


Asn Ile  Thr Ala Pro Phe Leu  Gln Pro Val Thr Leu  Gln Cys Ile 
    1820                 1825                 1830             


Gly Asp  Gly Val Pro Thr Pro  Ser Leu Arg Trp Trp  Lys Asp Gly 
    1835                 1840                 1845             


Val Ala  Leu Ala Ala Phe Gly  Gly Asn Leu Gln Ile  Glu Lys Val 
    1850                 1855                 1860             


Asp Leu  Arg Asp Glu Gly Ile  Tyr Thr Cys Ala Ala  Thr Asn Leu 
    1865                 1870                 1875             


Ala Gly  Glu Ser Lys Arg Glu  Val Ala Leu Lys Val  Leu Val Pro 
    1880                 1885                 1890             


Pro Asn  Ile Glu Pro Gly Pro  Val Asn Lys Ala Val  Leu Glu Asn 
    1895                 1900                 1905             


Ala Ser  Val Thr Leu Glu Cys  Leu Ala Ser Gly Val  Pro Pro Pro 
    1910                 1915                 1920             


Asp Val  Ser Trp Phe Lys Gly  His Gln Pro Val Ser  Ser Trp Met 
    1925                 1930                 1935             


Gly Val  Thr Val Ser Val Asp  Gly Arg Val Leu Arg  Ile Glu Gln 
    1940                 1945                 1950             


Ala Gln  Leu Ser Asp Ala Gly  Ser Tyr Arg Cys Val  Ala Ser Asn 
    1955                 1960                 1965             


Val Ala  Gly Ser Thr Glu Leu  Arg Tyr Gly Leu Arg  Val Asn Val 
    1970                 1975                 1980             


Pro Pro  Arg Ile Thr Leu Pro  Pro Ser Leu Pro Gly  Pro Val Leu 
    1985                 1990                 1995             


Val Asn  Thr Pro Val Arg Leu  Thr Cys Asn Ala Thr  Gly Ala Pro 
    2000                 2005                 2010             


Ser Pro  Thr Leu Met Trp Leu  Lys Asp Gly Asn Pro  Val Ser Pro 
    2015                 2020                 2025             


Ala Gly  Thr Pro Gly Leu Gln  Val Phe Pro Gly Gly  Arg Val Leu 
    2030                 2035                 2040             


Thr Leu  Ala Ser Ala Arg Ala  Ser Asp Ser Gly Arg  Tyr Ser Cys 
    2045                 2050                 2055             


Val Ala  Val Ser Ala Val Gly  Glu Asp Arg Gln Asp  Val Val Leu 
    2060                 2065                 2070             


Gln Val  His Met Pro Pro Ser  Ile Leu Gly Glu Glu  Leu Asn Val 
    2075                 2080                 2085             


Ser Val  Val Ala Asn Glu Ser  Val Ala Leu Glu Cys  Gln Ser His 
    2090                 2095                 2100             


Ala Met  Pro Pro Pro Val Leu  Ser Trp Trp Lys Asp  Gly Arg Pro 
    2105                 2110                 2115             


Leu Glu  Pro Arg Pro Gly Val  His Leu Ser Ala Asp  Lys Ala Leu 
    2120                 2125                 2130             


Leu Gln  Val Asp Arg Ala Asp  Val Trp Asp Ala Gly  His Tyr Thr 
    2135                 2140                 2145             


Cys Glu  Ala Leu Asn Gln Ala  Gly His Ser Glu Lys  His Tyr Asn 
    2150                 2155                 2160             


Leu Asn  Val Trp Val Ala Pro  Val Phe Pro Leu Arg  Glu Ser His 
    2165                 2170                 2175             


Thr Leu  Thr Val Arg Glu Gly  His Pro Thr Arg Leu  Ser Cys Glu 
    2180                 2185                 2190             


Cys Arg  Gly Val Pro Phe Pro  Lys Ile Ser Trp Arg  Lys Asp Gly 
    2195                 2200                 2205             


Gln Pro  Leu Pro Gly Glu Gly  Ala Gly Leu Gln His  Val Ser Ala 
    2210                 2215                 2220             


Val Gly  Arg Leu Leu Tyr Leu  Gly Gln Ala Gln Leu  Ala Gln Glu 
    2225                 2230                 2235             


Gly Thr  Tyr Thr Cys Glu Cys  Ser Asn Val Val Gly  Asn Ser Ser 
    2240                 2245                 2250             


Gln Asp  Leu Gln Leu Glu Val  His Val Pro Pro Gln  Ile Ala Gly 
    2255                 2260                 2265             


Pro Arg  Glu Pro Pro Thr Gln  Val Ser Val Val Gln  Asp Gly Val 
    2270                 2275                 2280             


Ala Thr  Leu Glu Cys Asn Ala  Thr Gly Lys Pro Pro  Pro Thr Val 
    2285                 2290                 2295             


Thr Trp  Glu Arg Asp Gly Gln  Pro Val Gly Ala Glu  Leu Gly Leu 
    2300                 2305                 2310             


Gln Leu  Gln Asn Gln Gly Gln  Ser Leu His Val Glu  Arg Ala Gln 
    2315                 2320                 2325             


Ala Ala  His Thr Gly Arg Tyr  Ser Cys Val Ala Glu  Asn Leu Ala 
    2330                 2335                 2340             


Gly Arg  Ala Glu Arg Lys Phe  Glu Leu Ser Val Leu  Val Pro Pro 
    2345                 2350                 2355             


Glu Leu  Ile Gly Asp Leu Asp  Pro Leu Thr Asn Ile  Thr Ala Ala 
    2360                 2365                 2370             


Leu His  Ser Pro Leu Thr Leu  Leu Cys Glu Ala Met  Gly Ile Pro 
    2375                 2380                 2385             


Pro Pro  Ala Ile Arg Trp Phe  Arg Gly Glu Glu Pro  Val Ser Pro 
    2390                 2395                 2400             


Gly Glu  Asp Thr Tyr Leu Leu  Ala Gly Gly Trp Met  Leu Lys Met 
    2405                 2410                 2415             


Thr Gln  Thr Gln Glu Gln Asp  Ser Gly Leu Tyr Ser  Cys Leu Ala 
    2420                 2425                 2430             


Ser Asn  Glu Ala Gly Glu Ala  Arg Arg Asn Phe Ser  Val Glu Val 
    2435                 2440                 2445             


Leu Val  Pro Pro Ser Ile Glu  Asn Glu Asp Leu Glu  Glu Val Ile 
    2450                 2455                 2460             


Lys Val  Leu Asp Gly Gln Thr  Ala His Leu Met Cys  Asn Val Thr 
    2465                 2470                 2475             


Gly His  Pro Gln Pro Lys Leu  Thr Trp Phe Lys Asp  Gly Arg Pro 
    2480                 2485                 2490             


Leu Ala  Arg Gly Asp Ala His  His Ile Ser Pro Asp  Gly Val Leu 
    2495                 2500                 2505             


Leu Gln  Val Leu Gln Ala Asn  Leu Ser Ser Ala Gly  His Tyr Ser 
    2510                 2515                 2520             


Cys Ile  Ala Ala Asn Ala Val  Gly Glu Lys Thr Lys  His Phe Gln 
    2525                 2530                 2535             


Leu Ser  Val Leu Leu Ala Pro  Thr Ile Leu Gly Gly  Ala Glu Asp 
    2540                 2545                 2550             


Ser Ala  Asp Glu Glu Val Thr  Val Thr Val Asn Asn  Pro Ile Ser 
    2555                 2560                 2565             


Leu Ile  Cys Glu Ala Leu Ala  Phe Pro Ser Pro Asn  Ile Thr Trp 
    2570                 2575                 2580             


Met Lys  Asp Gly Ala Pro Phe  Glu Ala Ser Arg Asn  Ile Gln Leu 
    2585                 2590                 2595             


Leu Pro  Gly Thr His Gly Leu  Gln Ile Leu Asn Ala  Gln Lys Glu 
    2600                 2605                 2610             


Asp Ala  Gly Gln Tyr Thr Cys  Val Val Thr Asn Glu  Leu Gly Glu 
    2615                 2620                 2625             


Ala Val  Lys Asn Tyr His Val  Glu Val Leu Ile Pro  Pro Ser Ile 
    2630                 2635                 2640             


Ser Lys  Asp Asp Pro Leu Ala  Glu Val Gly Val Lys  Glu Val Lys 
    2645                 2650                 2655             


Thr Lys  Val Asn Ser Thr Leu  Thr Leu Glu Cys Glu  Ser Trp Ala 
    2660                 2665                 2670             


Val Pro  Pro Pro Thr Ile Arg  Trp Tyr Lys Asp Gly  Gln Pro Val 
    2675                 2680                 2685             


Thr Pro  Ser Ser Arg Leu Gln  Val Leu Gly Glu Gly  Arg Leu Leu 
    2690                 2695                 2700             


Gln Ile  Gln Pro Thr Gln Val  Ser Asp Ser Gly Arg  Tyr Leu Cys 
    2705                 2710                 2715             


Val Ala  Thr Asn Val Ala Gly  Glu Asp Asp Gln Asp  Phe Asn Val 
    2720                 2725                 2730             


Leu Ile  Gln Val Pro Pro Met  Phe Gln Lys Val Gly  Asp Phe Ser 
    2735                 2740                 2745             


Ala Ala  Phe Glu Ile Leu Ser  Arg Glu Glu Glu Ala  Arg Gly Gly 
    2750                 2755                 2760             


Val Thr  Glu Tyr Arg Glu Ile  Val Glu Asn Asn Pro  Ala Tyr Leu 
    2765                 2770                 2775             


Tyr Cys  Asp Thr Asn Ala Ile  Pro Pro Pro Asp Leu  Thr Trp Tyr 
    2780                 2785                 2790             


Arg Glu  Asp Gln Pro Leu Ser  Ala Gly Asp Glu Val  Ser Val Leu 
    2795                 2800                 2805             


Gln Gly  Gly Arg Val Leu Gln  Ile Pro Leu Val Arg  Ala Glu Asn 
    2810                 2815                 2820             


Ala Gly  Arg Tyr Ser Cys Lys  Ala Ser Asn Glu Val  Gly Glu Asp 
    2825                 2830                 2835             


Trp Leu  His Tyr Glu Leu Leu  Val Leu Thr Pro Pro  Val Ile Leu 
    2840                 2845                 2850             


Gly Asp  Thr Glu Glu Leu Val  Glu Glu Val Thr Val  Asn Ala Ser 
    2855                 2860                 2865             


Ser Thr  Val Ser Leu Gln Cys  Pro Ala Leu Gly Asn  Pro Val Pro 
    2870                 2875                 2880             


Thr Ile  Ser Trp Leu Gln Asn  Gly Leu Pro Phe Ser  Pro Ser Pro 
    2885                 2890                 2895             


Arg Leu  Gln Val Leu Glu Asp  Gly Gln Val Leu Gln  Val Ser Thr 
    2900                 2905                 2910             


Ala Glu  Val Ala Asp Ala Ala  Ser Tyr Met Cys Val  Ala Glu Asn 
    2915                 2920                 2925             


Gln Ala  Gly Ser Ala Glu Lys  Leu Phe Thr Leu Arg  Val Gln Val 
    2930                 2935                 2940             


Pro Pro  Arg Ile Ala Gly Leu  Asp Leu Glu Gln Val  Thr Ala Ile 
    2945                 2950                 2955             


Leu Asn  Ser Ser Val Ser Leu  Pro Cys Asp Val His  Ala His Pro 
    2960                 2965                 2970             


Asn Pro  Glu Val Thr Trp Tyr  Lys Asp Ser Gln Ala  Leu Ser Leu 
    2975                 2980                 2985             


Gly Glu  Glu Val Phe Leu Leu  Pro Gly Thr His Thr  Leu Gln Leu 
    2990                 2995                 3000             


Gly Arg  Ala Arg Leu Ser Asp  Ser Gly Met Tyr Thr  Cys Glu Ala 
    3005                 3010                 3015             


Leu Asn  Ala Ala Gly Arg Asp  Gln Lys Leu Val Gln  Leu Ser Val 
    3020                 3025                 3030             


Leu Val  Pro Pro Ala Phe Arg  Gln Ala Pro Arg Gly  Pro Gln Asp 
    3035                 3040                 3045             


Ala Val  Leu Val Arg Val Gly  Asp Lys Ala Val Leu  Ser Cys Glu 
    3050                 3055                 3060             


Thr Asp  Ala Leu Pro Glu Pro  Thr Val Thr Trp Tyr  Lys Asp Gly 
    3065                 3070                 3075             


Gln Pro  Leu Val Leu Ala Gln  Arg Thr Gln Ala Leu  Arg Gly Gly 
    3080                 3085                 3090             


Gln Arg  Leu Glu Ile Gln Glu  Ala Gln Val Ser Asp  Lys Gly Leu 
    3095                 3100                 3105             


Tyr Ser  Cys Lys Val Ser Asn  Val Ala Gly Glu Ala  Val Arg Thr 
    3110                 3115                 3120             


Phe Thr  Leu Thr Val Gln Val  Pro Pro Thr Phe Glu  Asn Pro Lys 
    3125                 3130                 3135             


Thr Glu  Thr Val Ser Gln Val  Ala Gly Ser Pro Leu  Val Leu Thr 
    3140                 3145                 3150             


Cys Asp  Val Ser Gly Val Pro  Ala Pro Thr Val Thr  Trp Leu Lys 
    3155                 3160                 3165             


Asp Arg  Met Pro Val Glu Ser  Ser Ala Val His Gly  Val Val Ser 
    3170                 3175                 3180             


Arg Gly  Gly Arg Leu Gln Leu  Ser Arg Leu Gln Pro  Ala Gln Ala 
    3185                 3190                 3195             


Gly Thr  Tyr Thr Cys Val Ala  Glu Asn Thr Gln Ala  Glu Ala Arg 
    3200                 3205                 3210             


Lys Asp  Phe Val Val Ala Val  Leu Val Ala Pro Arg  Ile Arg Ser 
    3215                 3220                 3225             


Ser Gly  Val Ala Arg Glu His  His Val Leu Glu Gly  Gln Glu Val 
    3230                 3235                 3240             


Arg Leu  Asp Cys Glu Ala Asp  Gly Gln Pro Pro Pro  Asp Val Ala 
    3245                 3250                 3255             


Trp Leu  Lys Asp Gly Ser Pro  Leu Gly Gln Asp Met  Gly Pro His 
    3260                 3265                 3270             


Leu Arg  Phe Tyr Leu Asp Gly  Gly Ser Leu Val Leu  Lys Gly Leu 
    3275                 3280                 3285             


Arg Ala  Ser Asp Ala Gly Ala  Tyr Thr Cys Val Ala  His Asn Pro 
    3290                 3295                 3300             


Ala Gly  Glu Asp Ala Arg Leu  His Thr Val Asn Val  Leu Val Pro 
    3305                 3310                 3315             


Pro Thr  Ile Lys Gln Gly Ala  Asp Gly Ser Gly Thr  Leu Val Ser 
    3320                 3325                 3330             


Arg Pro  Gly Glu Leu Val Thr  Met Val Cys Pro Val  Arg Gly Ser 
    3335                 3340                 3345             


Pro Pro  Ile His Val Ser Trp  Leu Lys Asp Gly Leu  Pro Leu Pro 
    3350                 3355                 3360             


Leu Ser  Gln Arg Thr Leu Leu  His Gly Ser Gly His  Thr Leu Arg 
    3365                 3370                 3375             


Ile Ser  Lys Val Gln Leu Ala  Asp Ala Gly Ile Phe  Thr Cys Val 
    3380                 3385                 3390             


Ala Ala  Ser Pro Ala Gly Val  Ala Asp Arg Asn Phe  Thr Leu Gln 
    3395                 3400                 3405             


Val Gln  Val Pro Pro Val Leu  Glu Pro Val Glu Phe  Gln Asn Asp 
    3410                 3415                 3420             


Val Val  Val Val Arg Gly Ser  Leu Val Glu Leu Pro  Cys Glu Ala 
    3425                 3430                 3435             


Arg Gly  Val Pro Leu Pro Leu  Val Ser Trp Met Lys  Asp Gly Glu 
    3440                 3445                 3450             


Pro Leu  Leu Ser Gln Ser Leu  Glu Gln Gly Pro Ser  Leu Gln Leu 
    3455                 3460                 3465             


Glu Ala  Val Gly Ala Gly Asp  Ser Gly Thr Tyr Ser  Cys Val Ala 
    3470                 3475                 3480             


Val Ser  Glu Ala Gly Glu Ala  Arg Arg His Phe Gln  Leu Thr Val 
    3485                 3490                 3495             


Met Glu  Pro Pro His Ile Glu  Asp Ser Gly Gln Pro  Thr Glu Leu 
    3500                 3505                 3510             


Ser Leu  Thr Pro Gly Ala Pro  Met Glu Leu Leu Cys  Asp Ala Gln 
    3515                 3520                 3525             


Gly Thr  Pro Gln Pro Asn Ile  Thr Trp His Lys Asp  Gly Gln Ala 
    3530                 3535                 3540             


Leu Thr  Arg Leu Glu Asn Asn  Ser Arg Ala Thr Arg  Val Leu Arg 
    3545                 3550                 3555             


Val Glu  Asn Val Gln Val Arg  Asp Ala Gly Leu Tyr  Thr Cys Leu 
    3560                 3565                 3570             


Ala Glu  Ser Pro Ala Gly Ala  Ile Glu Lys Ser Phe  Arg Val Arg 
    3575                 3580                 3585             


Val Gln  Ala Pro Pro Asn Ile  Val Gly Pro Arg Gly  Pro Arg Phe 
    3590                 3595                 3600             


Val Val  Gly Leu Ala Pro Gly  Gln Leu Val Leu Glu  Cys Ser Val 
    3605                 3610                 3615             


Glu Ala  Glu Pro Ala Pro Lys  Ile Thr Trp His Arg  Asp Gly Ile 
    3620                 3625                 3630             


Val Leu  Gln Glu Asp Ala His  Thr Gln Phe Pro Glu  Arg Gly Arg 
    3635                 3640                 3645             


Phe Leu  Gln Leu Gln Ala Leu  Ser Thr Ala Asp Ser  Gly Asp Tyr 
    3650                 3655                 3660             


Ser Cys  Thr Ala Arg Asn Ala  Ala Gly Ser Thr Ser  Val Ala Phe 
    3665                 3670                 3675             


Arg Val  Glu Ile His Thr Val  Pro Thr Ile Arg Ser  Gly Pro Pro 
    3680                 3685                 3690             


Ala Val  Asn Val Ser Val Asn  Gln Thr Ala Leu Leu  Pro Cys Gln 
    3695                 3700                 3705             


Ala Asp  Gly Val Pro Ala Pro  Leu Val Ser Trp Arg  Lys Asp Arg 
    3710                 3715                 3720             


Val Pro  Leu Asp Pro Arg Ser  Pro Arg Phe Glu Ile  Leu Pro Glu 
    3725                 3730                 3735             


Gly Ser  Leu Arg Ile Gln Pro  Val Leu Ala Gln Asp  Ala Gly His 
    3740                 3745                 3750             


Tyr Leu  Cys Leu Ala Ser Asn  Ser Ala Gly Ser Asp  Arg Gln Gly 
    3755                 3760                 3765             


Arg Asp  Leu Arg Val Leu Ala  Leu Leu Pro Cys Glu  Ala Ser Gly 
    3770                 3775                 3780             


Ser Pro  Lys Pro Leu Val Val  Trp Trp Lys Asp Gly  Gln Lys Leu 
    3785                 3790                 3795             


Asp Phe  Arg Leu Gln Gln Gly  Ala Tyr Arg Leu Leu  Pro Ser Asn 
    3800                 3805                 3810             


Ala Leu  Leu Leu Thr Ala Pro  Gly Pro Gln Asp Ser  Ala Gln Phe 
    3815                 3820                 3825             


Glu Cys  Val Val Ser Asn Glu  Val Gly Glu Ala His  Arg Leu Tyr 
    3830                 3835                 3840             


Gln Val  Thr Val His Val Pro  Pro Thr Ile Ala Asp  Asp Gln Thr 
    3845                 3850                 3855             


Asp Phe  Thr Val Thr Met Met  Ala Pro Val Val Leu  Thr Cys His 
    3860                 3865                 3870             


Ser Thr  Gly Ile Pro Ala Pro  Thr Val Ser Trp Ser  Lys Ala Gly 
    3875                 3880                 3885             


Ala Gln  Leu Gly Ala Arg Gly  Ser Gly Tyr Arg Val  Ser Pro Ser 
    3890                 3895                 3900             


Gly Ala  Leu Glu Ile Gly Gln  Ala Leu Pro Ile His  Ala Gly Arg 
    3905                 3910                 3915             


Tyr Thr  Cys Ser Ala Arg Asn  Ser Ala Gly Val Ala  His Lys His 
    3920                 3925                 3930             


Val Phe  Leu Thr Val Gln Ala  Ser Pro Val Val Lys  Pro Leu Pro 
    3935                 3940                 3945             


Ser Val  Val Arg Ala Val Ala  Glu Glu Glu Val Leu  Leu Pro Cys 
    3950                 3955                 3960             


Glu Ala  Ser Gly Ile Pro Arg  Pro Thr Ile Thr Trp  Gln Lys Glu 
    3965                 3970                 3975             


Gly Leu  Asn Val Ala Thr Gly  Val Ser Thr Gln Val  Leu Pro Gly 
    3980                 3985                 3990             


Gly Gln  Leu Arg Ile Ala His  Ala Ser Pro Glu Asp  Ala Gly Asn 
    3995                 4000                 4005             


Tyr Leu  Cys Ile Ala Lys Asn  Ser Ala Gly Ser Ala  Met Gly Lys 
    4010                 4015                 4020             


Thr Arg  Leu Val Val Gln Val  Pro Pro Val Ile Glu  Asn Gly Leu 
    4025                 4030                 4035             


Pro Asp  Leu Ser Thr Thr Glu  Gly Ser His Ala Phe  Leu Pro Cys 
    4040                 4045                 4050             


Lys Ala  Arg Gly Ser Pro Glu  Pro Asn Ile Thr Trp  Asp Lys Asp 
    4055                 4060                 4065             


Gly Gln  Pro Val Ser Gly Ala  Glu Gly Lys Phe Thr  Ile Gln Pro 
    4070                 4075                 4080             


Ser Gly  Glu Leu Leu Val Lys  Asn Leu Glu Gly Gln  Asp Ala Gly 
    4085                 4090                 4095             


Thr Tyr  Thr Cys Thr Ala Glu  Asn Ala Val Gly Arg  Ala Arg Arg 
    4100                 4105                 4110             


Arg Val  His Leu Thr Ile Leu  Val Leu Pro Val Phe  Thr Thr Leu 
    4115                 4120                 4125             


Pro Gly  Asp Arg Ser Leu Arg  Leu Gly Asp Arg Leu  Trp Leu Arg 
    4130                 4135                 4140             


Cys Ala  Ala Arg Gly Ser Pro  Thr Pro Arg Ile Gly  Trp Thr Val 
    4145                 4150                 4155             


Asn Asp  Arg Pro Val Thr Glu  Gly Val Ser Glu Gln  Asp Gly Gly 
    4160                 4165                 4170             


Ser Thr  Leu Gln Arg Ala Ala  Val Ser Arg Glu Asp  Ser Gly Thr 
    4175                 4180                 4185             


Tyr Val  Cys Trp Ala Glu Asn  Arg Val Gly Arg Thr  Gln Ala Val 
    4190                 4195                 4200             


Ser Phe  Val His Val Lys Glu  Ala Pro Val Leu Gln  Gly Glu Ala 
    4205                 4210                 4215             


Phe Ser  Tyr Leu Val Glu Pro  Val Gly Gly Ser Ile  Gln Leu Asp 
    4220                 4225                 4230             


Cys Val  Val Arg Gly Asp Pro  Val Pro Asp Ile His  Trp Ile Lys 
    4235                 4240                 4245             


Asp Gly  Leu Pro Leu Arg Gly  Ser His Leu Arg His  Gln Leu Gln 
    4250                 4255                 4260             


Asn Gly  Ser Leu Thr Ile Arg  Arg Thr Glu Arg Asp  Asp Ala Gly 
    4265                 4270                 4275             


Arg Tyr  Gln Cys Leu Ala Glu  Asn Glu Met Gly Val  Ala Lys Lys 
    4280                 4285                 4290             


Val Val  Ile Leu Val Leu Gln  Ser Ala Pro Val Phe  Gln Val Glu 
    4295                 4300                 4305             


Pro Gln  Asp Met Thr Val Arg  Ser Gly Asp Asp Val  Ala Leu Arg 
    4310                 4315                 4320             


Cys Gln  Ala Thr Gly Glu Pro  Thr Pro Thr Ile Glu  Trp Leu Gln 
    4325                 4330                 4335             


Ala Gly  Gln Pro Leu Arg Ala  Ser Arg Arg Leu Arg  Thr Leu Pro 
    4340                 4345                 4350             


Asp Gly  Ser Leu Trp Leu Glu  Asn Val Glu Thr Gly  Asp Ala Gly 
    4355                 4360                 4365             


Thr Tyr  Asp Cys Val Ala His  Asn Leu Leu Gly Ser  Ala Thr Ala 
    4370                 4375                 4380             


Arg Ala  Phe Leu Val Val Arg  Gly Glu Pro Gln Gly  Ser Trp Gly 
    4385                 4390                 4395             


Ser Met  Thr Gly Val Ile Asn  Gly Arg Lys Phe Gly  Val Ala Thr 
    4400                 4405                 4410             


Leu Asn  Thr Ser Val Met Gln  Glu Ala His Ser Gly  Val Ser Ser 
    4415                 4420                 4425             


Ile His  Ser Ser Ile Arg His  Val Pro Ala Asn Val  Gly Pro Leu 
    4430                 4435                 4440             


Met Arg  Val Leu Val Val Thr  Ile Ala Pro Ile Tyr  Trp Ala Leu 
    4445                 4450                 4455             


Ala Arg  Glu Ser Gly Glu Ala  Leu Asn Gly His Ser  Leu Thr Gly 
    4460                 4465                 4470             


Gly Arg  Phe Arg Gln Glu Ser  His Val Glu Phe Ala  Thr Gly Glu 
    4475                 4480                 4485             


Leu Leu  Thr Met Thr Gln Val  Ala Arg Gly Leu Asp  Pro Asp Gly 
    4490                 4495                 4500             


Leu Leu  Leu Leu Asp Val Val  Val Asn Gly Val Val  Pro Glu Ser 
    4505                 4510                 4515             


Leu Ala  Asp Ala Asp Leu Gln  Val Gln Asp Phe Glu  Glu His Tyr 
    4520                 4525                 4530             


Val Gln  Thr Gly Pro Gly Gln  Leu Phe Val Gly Ser  Thr Gln Arg 
    4535                 4540                 4545             


Phe Phe  Gln Gly Gly Leu Pro  Ser Phe Leu Arg Cys  Asn His Ser 
    4550                 4555                 4560             


Ile Gln  Tyr Asn Ala Ala Arg  Gly Pro Gln Pro Gln  Leu Val Gln 
    4565                 4570                 4575             


His Leu  Arg Ala Ser Ala Ile  Ser Ser Ala Phe Asp  Pro Glu Ala 
    4580                 4585                 4590             


Glu Ala  Leu Arg Phe Gln Leu  Ala Thr Ala Leu Gln  Ala Glu Glu 
    4595                 4600                 4605             


Asn Glu  Val Gly Cys Pro Glu  Gly Phe Glu Leu Asp  Ser Gln Gly 
    4610                 4615                 4620             


Ala Phe  Cys Val Asp Arg Asp  Glu Cys Ser Gly Gly  Pro Ser Pro 
    4625                 4630                 4635             


Cys Ser  His Ala Cys Leu Asn  Ala Pro Gly Arg Phe  Ser Cys Thr 
    4640                 4645                 4650             


Cys Pro  Thr Gly Phe Ala Leu  Ala Trp Asp Asp Arg  Asn Cys Arg 
    4655                 4660                 4665             


Asp Val  Asp Glu Cys Ala Trp  Asp Ala His Leu Cys  Arg Glu Gly 
    4670                 4675                 4680             


Gln Arg  Cys Val Asn Leu Leu  Gly Ser Tyr Arg Cys  Leu Pro Asp 
    4685                 4690                 4695             


Cys Gly  Pro Gly Phe Arg Val  Ala Asp Gly Ala Gly  Cys Glu Asp 
    4700                 4705                 4710             


Val Asp  Glu Cys Leu Glu Gly  Leu Asp Asp Cys His  Tyr Asn Gln 
    4715                 4720                 4725             


Leu Cys  Glu Asn Thr Pro Gly  Gly His Arg Cys Ser  Cys Pro Arg 
    4730                 4735                 4740             


Gly Tyr  Arg Met Gln Gly Pro  Ser Leu Pro Cys Leu  Asp Val Asn 
    4745                 4750                 4755             


Glu Cys  Leu Gln Leu Pro Lys  Ala Cys Ala Tyr Gln  Cys His Asn 
    4760                 4765                 4770             


Leu Gln  Gly Ser Tyr Arg Cys  Leu Cys Pro Pro Gly  Gln Thr Leu 
    4775                 4780                 4785             


Leu Arg  Asp Gly Lys Ala Cys  Thr Ser Leu Glu Arg  Asn Gly Gln 
    4790                 4795                 4800             


Asn Val  Thr Thr Val Ser His  Arg Gly Pro Leu Leu  Pro Trp Leu 
    4805                 4810                 4815             


Arg Pro  Trp Ala Ser Ile Pro  Gly Thr Ser Tyr His  Ala Trp Val 
    4820                 4825                 4830             


Ser Leu  Arg Pro Gly Pro Met  Ala Leu Ser Ser Val  Gly Arg Ala 
    4835                 4840                 4845             


Trp Cys  Pro Pro Gly Phe Ile  Arg Gln Asn Gly Val  Cys Thr Asp 
    4850                 4855                 4860             


Leu Asp  Glu Cys Arg Val Arg  Asn Leu Cys Gln His  Ala Cys Arg 
    4865                 4870                 4875             


Asn Thr  Glu Gly Ser Tyr Gln  Cys Leu Cys Pro Ala  Gly Tyr Arg 
    4880                 4885                 4890             


Leu Leu  Pro Ser Gly Lys Asn  Cys Gln Asp Ile Asn  Glu Cys Glu 
    4895                 4900                 4905             


Glu Glu  Ser Ile Glu Cys Gly  Pro Gly Gln Met Cys  Phe Asn Thr 
    4910                 4915                 4920             


Arg Gly  Ser Tyr Gln Cys Val  Asp Thr Pro Cys Pro  Ala Thr Tyr 
    4925                 4930                 4935             


Arg Gln  Gly Pro Ser Pro Gly  Thr Cys Phe Arg Arg  Cys Ser Gln 
    4940                 4945                 4950             


Asp Cys  Gly Thr Gly Gly Pro  Ser Thr Leu Gln Tyr  Arg Leu Leu 
    4955                 4960                 4965             


Pro Leu  Pro Leu Gly Val Arg  Ala His His Asp Val  Ala Arg Leu 
    4970                 4975                 4980             


Thr Ala  Phe Ser Glu Val Gly  Val Pro Ala Asn Arg  Thr Glu Leu 
    4985                 4990                 4995             


Ser Met  Leu Glu Pro Asp Pro  Arg Ser Pro Phe Ala  Leu Arg Pro 
    5000                 5005                 5010             


Leu Arg  Ala Gly Leu Gly Ala  Val Tyr Thr Arg Arg  Ala Leu Thr 
    5015                 5020                 5025             


Arg Ala  Gly Leu Tyr Arg Leu  Thr Val Arg Ala Ala  Ala Pro Arg 
    5030                 5035                 5040             


His Gln  Ser Val Phe Val Leu  Leu Ile Ala Val Ser  Pro Tyr Pro 
    5045                 5050                 5055             


Tyr 
    


<210>  6523
<211>  309
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6523

Xaa Pro Gly Gln Leu Phe Val Gly Ser Thr Gln Arg Phe Phe Gln Gly 
1               5                   10                  15      


Gly Leu Pro Ser Phe Leu Arg Cys Asn His Ser Ile Gln Tyr Asn Ala 
            20                  25                  30          


Ala Arg Gly Pro Gln Pro Gln Leu Val Gln His Leu Arg Ala Ser Ala 
        35                  40                  45              


Ile Ser Ser Ala Phe Asp Pro Glu Ala Glu Ala Leu Arg Phe Gln Leu 
    50                  55                  60                  


Ala Thr Ala Leu Gln Ala Glu Glu Asn Glu Val Gly Cys Pro Glu Gly 
65                  70                  75                  80  


Phe Glu Leu Asp Ser Gln Gly Ala Phe Cys Val Asp Val Asp Glu Cys 
                85                  90                  95      


Ala Trp Asp Ala His Leu Cys Arg Glu Gly Gln Arg Cys Val Asn Leu 
            100                 105                 110         


Leu Gly Ser Tyr Arg Cys Leu Pro Asp Cys Gly Pro Gly Phe Arg Val 
        115                 120                 125             


Ala Asp Gly Ala Gly Cys Glu Asp Val Asp Glu Cys Leu Glu Gly Leu 
    130                 135                 140                 


Asp Asp Cys His Tyr Asn Gln Leu Cys Glu Asn Thr Pro Gly Gly His 
145                 150                 155                 160 


Arg Cys Ser Cys Pro Arg Gly Tyr Arg Met Gln Gly Pro Ser Leu Pro 
                165                 170                 175     


Cys Leu Asp Val Asn Glu Cys Leu Gln Leu Pro Lys Ala Cys Ala Tyr 
            180                 185                 190         


Gln Cys His Asn Leu Gln Gly Ser Tyr Arg Cys Leu Cys Pro Pro Gly 
        195                 200                 205             


Gln Thr Leu Leu Arg Asp Gly Lys Ala Cys Thr Ser Leu Glu Arg Asn 
    210                 215                 220                 


Gly Gln Asn Val Thr Thr Val Ser His Arg Gly Pro Leu Leu Pro Trp 
225                 230                 235                 240 


Leu Arg Pro Trp Ala Ser Ile Pro Gly Thr Ser Tyr His Ala Trp Val 
                245                 250                 255     


Ser Leu Arg Pro Gly Pro Met Ala Leu Ser Ser Val Gly Arg Ala Trp 
            260                 265                 270         


Cys Pro Pro Gly Phe Ile Arg Gln Asn Gly Val Cys Thr Asp Leu Asp 
        275                 280                 285             


Glu Cys Arg Val Arg Asn Leu Cys Gln His Ala Cys Arg Asn Thr Glu 
    290                 295                 300                 


Gly Ser Tyr Gln Cys 
305                 


<210>  6524
<211>  479
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6524

Xaa Val His Ala His Pro Asn Pro Glu Val Thr Trp Tyr Lys Asp Ser 
1               5                   10                  15      


Gln Ala Leu Ser Leu Gly Glu Glu Val Phe Leu Leu Pro Gly Thr His 
            20                  25                  30          


Thr Leu Gln Leu Gly Arg Ala Arg Leu Ser Asp Ser Gly Met Tyr Thr 
        35                  40                  45              


Cys Glu Ala Leu Asn Ala Ala Gly Arg Asp Gln Lys Leu Val Gln Leu 
    50                  55                  60                  


Ser Val Leu Val Pro Pro Ala Phe Arg Gln Ala Pro Arg Gly Pro Gln 
65                  70                  75                  80  


Asp Ala Val Leu Val Arg Val Gly Asp Lys Ala Val Leu Ser Cys Glu 
                85                  90                  95      


Thr Asp Ala Leu Pro Glu Pro Thr Val Thr Trp Tyr Lys Asp Gly Gln 
            100                 105                 110         


Pro Leu Val Leu Ala Gln Arg Thr Gln Ala Leu Arg Gly Gly Gln Arg 
        115                 120                 125             


Leu Glu Ile Gln Glu Ala Gln Val Ser Asp Lys Gly Leu Tyr Ser Cys 
    130                 135                 140                 


Lys Val Ser Asn Val Ala Gly Glu Ala Val Arg Thr Phe Thr Leu Thr 
145                 150                 155                 160 


Val Gln Val Pro Pro Thr Phe Glu Asn Pro Lys Thr Glu Thr Val Ser 
                165                 170                 175     


Gln Val Ala Gly Ser Pro Leu Val Leu Thr Cys Asp Val Ser Gly Val 
            180                 185                 190         


Pro Ala Pro Thr Val Thr Trp Leu Lys Asp Arg Met Pro Val Glu Ser 
        195                 200                 205             


Ser Ala Val His Gly Val Val Ser Arg Gly Gly Arg Leu Gln Leu Ser 
    210                 215                 220                 


Arg Leu Gln Pro Ala Gln Ala Gly Thr Tyr Thr Cys Val Ala Glu Asn 
225                 230                 235                 240 


Thr Gln Ala Glu Ala Arg Lys Asp Phe Val Val Ala Val Leu Val Ala 
                245                 250                 255     


Pro Arg Ile Arg Ser Ser Gly Val Ala Arg Glu His His Val Leu Glu 
            260                 265                 270         


Gly Gln Glu Val Arg Leu Asp Cys Glu Ala Asp Gly Gln Pro Pro Pro 
        275                 280                 285             


Asp Val Ala Trp Leu Lys Asp Gly Ser Pro Leu Gly Gln Asp Met Gly 
    290                 295                 300                 


Pro His Leu Arg Phe Tyr Leu Asp Gly Gly Ser Leu Val Leu Lys Gly 
305                 310                 315                 320 


Leu Arg Ala Ser Asp Ala Gly Ala Tyr Thr Cys Val Ala His Asn Pro 
                325                 330                 335     


Ala Gly Glu Asp Ala Arg Leu His Thr Val Asn Val Leu Val Pro Pro 
            340                 345                 350         


Thr Ile Lys Gln Gly Ala Asp Gly Ser Gly Thr Leu Val Ser Arg Pro 
        355                 360                 365             


Gly Glu Leu Val Thr Met Val Cys Pro Val Arg Gly Ser Pro Pro Ile 
    370                 375                 380                 


His Val Ser Trp Leu Lys Asp Gly Leu Pro Leu Pro Leu Ser Gln Arg 
385                 390                 395                 400 


Thr Leu Leu His Gly Ser Gly His Thr Leu Arg Ile Ser Lys Val Gln 
                405                 410                 415     


Leu Ala Asp Ala Gly Ile Phe Thr Cys Val Ala Ala Ser Pro Ala Gly 
            420                 425                 430         


Val Ala Asp Arg Asn Phe Thr Leu Gln Cys Pro Leu Ser Trp Ser Arg 
        435                 440                 445             


Trp Ser Ser Arg Met Thr Trp Trp Trp Phe Val Ala Pro Trp Trp Asn 
    450                 455                 460                 


Ser Arg Ala Arg Pro Gly Ala Phe Pro Cys Leu Ser Cys Arg Gly 
465                 470                 475                 


<210>  6525
<211>  325
<212>  PRT
<213>  Homo Sapiens

<400>  6525

Met Ala Ala Met Arg Lys Ala Leu Pro Arg Arg Leu Val Gly Leu Ala 
1               5                   10                  15      


Ser Leu Arg Ala Val Ser Thr Ser Ser Met Gly Thr Leu Pro Lys Arg 
            20                  25                  30          


Val Lys Ile Val Glu Val Gly Pro Arg Asp Gly Leu Gln Asn Glu Lys 
        35                  40                  45              


Asn Ile Val Ser Thr Pro Val Lys Ile Lys Leu Ile Asp Met Leu Ser 
    50                  55                  60                  


Glu Ala Gly Leu Ser Val Ile Glu Thr Thr Ser Phe Val Ser Pro Lys 
65                  70                  75                  80  


Trp Val Pro Gln Met Gly Asp His Thr Glu Val Leu Lys Gly Ile Gln 
                85                  90                  95      


Lys Phe Pro Gly Ile Asn Tyr Pro Val Leu Thr Pro Asn Leu Lys Gly 
            100                 105                 110         


Phe Glu Ala Ala Val Ala Ala Gly Ala Lys Glu Val Val Ile Phe Gly 
        115                 120                 125             


Ala Ala Ser Glu Leu Phe Thr Lys Lys Asn Ile Asn Cys Ser Ile Glu 
    130                 135                 140                 


Glu Ser Phe Gln Arg Phe Asp Ala Ile Leu Lys Ala Ala Gln Ser Ala 
145                 150                 155                 160 


Asn Ile Ser Val Arg Gly Tyr Val Ser Cys Ala Leu Gly Cys Pro Tyr 
                165                 170                 175     


Glu Gly Lys Ile Ser Pro Ala Lys Val Ala Glu Val Thr Lys Lys Phe 
            180                 185                 190         


Tyr Ser Met Gly Cys Tyr Glu Ile Ser Leu Gly Asp Thr Ile Gly Val 
        195                 200                 205             


Gly Thr Pro Gly Ile Met Lys Asp Met Leu Ser Ala Val Met Gln Glu 
    210                 215                 220                 


Val Pro Leu Ala Ala Leu Ala Val His Cys His Asp Thr Tyr Gly Gln 
225                 230                 235                 240 


Ala Leu Ala Asn Thr Leu Met Ala Leu Gln Met Gly Val Ser Val Val 
                245                 250                 255     


Asp Ser Ser Val Ala Gly Leu Gly Gly Cys Pro Tyr Ala Gln Gly Ala 
            260                 265                 270         


Ser Gly Asn Leu Ala Thr Glu Asp Leu Val Tyr Met Leu Glu Gly Leu 
        275                 280                 285             


Gly Ile His Thr Gly Val Asn Leu Gln Lys Leu Leu Glu Ala Gly Asn 
    290                 295                 300                 


Phe Ile Cys Gln Ala Leu Asn Arg Lys Thr Ser Ser Lys Val Ala Gln 
305                 310                 315                 320 


Ala Thr Cys Lys Leu 
                325 


<210>  6526
<211>  254
<212>  PRT
<213>  Homo Sapiens

<400>  6526

Met Ala Ala Met Arg Lys Ala Leu Pro Arg Arg Leu Val Gly Leu Ala 
1               5                   10                  15      


Ser Leu Arg Ala Val Ser Thr Ser Ser Met Gly Thr Leu Pro Lys Arg 
            20                  25                  30          


Val Lys Ile Val Glu Val Gly Pro Arg Asp Gly Leu Gln Asn Glu Lys 
        35                  40                  45              


Asn Ile Val Ser Thr Pro Val Lys Ile Lys Leu Ile Asp Met Leu Ser 
    50                  55                  60                  


Glu Ala Gly Leu Ser Val Ile Glu Thr Thr Ser Phe Val Ser Pro Lys 
65                  70                  75                  80  


Trp Val Pro Gln Met Gly Asp His Thr Glu Val Leu Lys Gly Ile Gln 
                85                  90                  95      


Lys Phe Pro Gly Ile Asn Tyr Pro Val Leu Thr Pro Asn Leu Lys Gly 
            100                 105                 110         


Phe Glu Ala Ala Val Thr Lys Lys Phe Tyr Ser Met Gly Cys Tyr Glu 
        115                 120                 125             


Ile Ser Leu Gly Asp Thr Ile Gly Val Gly Thr Pro Gly Ile Met Lys 
    130                 135                 140                 


Asp Met Leu Ser Ala Val Met Gln Glu Val Pro Leu Ala Ala Leu Ala 
145                 150                 155                 160 


Val His Cys His Asp Thr Tyr Gly Gln Ala Leu Ala Asn Thr Leu Met 
                165                 170                 175     


Ala Leu Gln Met Gly Val Ser Val Val Asp Ser Ser Val Ala Gly Leu 
            180                 185                 190         


Gly Gly Cys Pro Tyr Ala Gln Gly Ala Ser Gly Asn Leu Ala Thr Glu 
        195                 200                 205             


Asp Leu Val Tyr Met Leu Glu Gly Leu Gly Ile His Thr Gly Val Asn 
    210                 215                 220                 


Leu Gln Lys Leu Leu Glu Ala Gly Asn Phe Ile Cys Gln Ala Leu Asn 
225                 230                 235                 240 


Arg Lys Thr Ser Ser Lys Val Ala Gln Ala Thr Cys Lys Leu 
                245                 250                 


<210>  6527
<211>  77
<212>  PRT
<213>  Homo Sapiens

<400>  6527

Met Leu Glu Ala Arg Arg Glu Trp Ser Arg Lys Val Phe Pro Trp Ser 
1               5                   10                  15      


Gly Ala Thr Gln Gln Pro Gly Thr Pro Phe His Ser Pro Ser Gln Thr 
            20                  25                  30          


Leu Arg Arg Ser Ala Gly Gln Arg Pro Ala Gly Val Pro Val Pro Ala 
        35                  40                  45              


Asp Val Leu Leu Trp Thr Ser Ser Arg Leu Cys Val Pro Pro Leu Met 
    50                  55                  60                  


Cys Ser Ser Pro Cys Pro Ala Thr Cys Val Ser Ala Cys 
65                  70                  75          


<210>  6528
<211>  182
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6528

Xaa Lys Ala Leu Pro Arg Arg Leu Val Gly Leu Ala Ser Leu Arg Ala 
1               5                   10                  15      


Val Ser Thr Ser Ser Met Gly Thr Leu Pro Lys Arg Val Lys Ile Val 
            20                  25                  30          


Glu Val Gly Pro Arg Asp Gly Leu Gln Asn Glu Lys Val Thr Lys Lys 
        35                  40                  45              


Phe Tyr Ser Met Gly Cys Tyr Glu Ile Ser Leu Gly Asp Thr Ile Gly 
    50                  55                  60                  


Val Gly Thr Pro Gly Ile Met Lys Asp Met Leu Ser Ala Val Met Gln 
65                  70                  75                  80  


Glu Val Pro Leu Ala Ala Leu Ala Val His Cys His Asp Thr Tyr Gly 
                85                  90                  95      


Gln Ala Leu Ala Asn Thr Leu Met Ala Leu Gln Met Gly Val Ser Val 
            100                 105                 110         


Val Asp Ser Ser Val Ala Gly Leu Gly Gly Cys Pro Tyr Ala Gln Gly 
        115                 120                 125             


Ala Ser Gly Asn Leu Ala Thr Glu Asp Leu Val Tyr Met Leu Glu Gly 
    130                 135                 140                 


Leu Gly Ile His Thr Gly Val Asn Leu Gln Lys Leu Leu Glu Ala Gly 
145                 150                 155                 160 


Asn Phe Ile Cys Gln Ala Leu Asn Arg Lys Thr Ser Ser Lys Val Ala 
                165                 170                 175     


Gln Ala Thr Cys Lys Leu 
            180         


<210>  6529
<211>  53
<212>  PRT
<213>  Homo Sapiens

<400>  6529

Met Glu Ile Phe Ile Glu Val Phe Ser His Phe Leu Leu Gln Leu Thr 
1               5                   10                  15      


Glu Leu Thr Leu Asn Met Cys Leu Glu Leu Pro Thr Gly Ser Leu Glu 
            20                  25                  30          


Lys Ser Leu Met Ile Ser Ser Gln Val Leu Gln Ile Pro Val Ala Asn 
        35                  40                  45              


Ser Thr Lys Gln Arg 
    50              


<210>  6530
<211>  139
<212>  PRT
<213>  Homo Sapiens

<400>  6530

Met Ser Ile Ser Ser Ala Leu Ala Met Val Phe Met Gly Ala Lys Gly 
1               5                   10                  15      


Asn Thr Ala Ala Gln Met Ser Gln Ala Leu Cys Phe Ser Lys Ile Gly 
            20                  25                  30          


Gly Glu Asp Gly Asp Ile His Arg Gly Phe Gln Ser Leu Leu Val Ala 
        35                  40                  45              


Ile Asn Arg Thr Asp Thr Glu Tyr Val Leu Arg Thr Ala Asn Gly Leu 
    50                  55                  60                  


Phe Gly Glu Lys Ser Tyr Asp Phe Leu Thr Gly Phe Thr Asp Ser Cys 
65                  70                  75                  80  


Gly Lys Phe Tyr Gln Ala Thr Ile Lys Gln Leu Asp Phe Val Asn Asp 
                85                  90                  95      


Thr Glu Lys Ser Thr Thr Arg Val Asn Ser Trp Val Ala Asp Lys Thr 
            100                 105                 110         


Lys Gly Glu Asn Ile Leu Leu Phe Tyr Phe Asp Asn Ile Leu Asn Ser 
        115                 120                 125             


Phe Ile Val Ser Ser Leu Gln Asn Cys Gln Ile 
    130                 135                 


<210>  6531
<211>  442
<212>  PRT
<213>  Homo Sapiens

<400>  6531

Met Ser Ala Leu Gly Ala Val Ile Ala Leu Leu Leu Trp Gly Gln Leu 
1               5                   10                  15      


Phe Ala Val Asp Ser Gly Asn Asp Val Thr Asp Ile Ala Asp Asp Gly 
            20                  25                  30          


Cys Pro Lys Pro Pro Glu Ile Ala His Gly Tyr Val Glu His Ser Val 
        35                  40                  45              


Arg Tyr Gln Cys Lys Asn Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Gly 
    50                  55                  60                  


Val Tyr Thr Leu Asn Asp Lys Lys Gln Trp Ile Asn Lys Ala Val Gly 
65                  70                  75                  80  


Asp Lys Leu Pro Glu Cys Glu Ala Asp Asp Gly Cys Pro Lys Pro Pro 
                85                  90                  95      


Glu Ile Ala His Gly Tyr Val Glu His Ser Val Arg Tyr Gln Cys Lys 
            100                 105                 110         


Asn Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Gly Glu Ala Met Pro Cys 
        115                 120                 125             


Ser Leu Pro His Val Asn Leu Arg Val Thr Phe Thr Ser Pro Ala Asp 
    130                 135                 140                 


Val Gly Lys Glu Gly Met Leu Met Met Met Ser Pro Ser Pro Arg Val 
145                 150                 155                 160 


Tyr Thr Leu Asn Asn Glu Lys Gln Trp Ile Asn Lys Ala Val Gly Asp 
                165                 170                 175     


Lys Leu Pro Glu Cys Glu Ala Val Cys Gly Lys Pro Lys Asn Pro Ala 
            180                 185                 190         


Asn Pro Val Gln Arg Ile Leu Gly Gly His Leu Asp Ala Lys Gly Ser 
        195                 200                 205             


Phe Pro Trp Gln Ala Lys Met Val Ser His His Asn Leu Thr Thr Gly 
    210                 215                 220                 


Ala Thr Leu Ile Asn Glu Gln Trp Leu Leu Thr Thr Ala Lys Asn Leu 
225                 230                 235                 240 


Phe Leu Asn His Ser Glu Asn Ala Thr Ala Lys Asp Ile Ala Pro Thr 
                245                 250                 255     


Leu Thr Leu Tyr Val Gly Lys Lys Gln Leu Val Glu Ile Glu Lys Val 
            260                 265                 270         


Val Leu His Pro Asn Tyr Ser Gln Val Asp Ile Gly Leu Ile Lys Leu 
        275                 280                 285             


Lys Gln Lys Val Ser Val Asn Glu Arg Val Met Pro Ile Cys Leu Pro 
    290                 295                 300                 


Ser Lys Asp Tyr Ala Glu Val Gly Arg Val Gly Tyr Val Ser Gly Trp 
305                 310                 315                 320 


Gly Arg Asn Ala Asn Phe Lys Phe Thr Asp His Leu Lys Tyr Val Met 
                325                 330                 335     


Leu Pro Val Ala Asp Gln Asp Gln Cys Ile Arg His Tyr Glu Gly Ser 
            340                 345                 350         


Thr Val Pro Glu Lys Lys Thr Pro Lys Ser Pro Val Gly Val Gln Pro 
        355                 360                 365             


Ile Leu Asn Glu His Thr Phe Cys Ala Gly Met Ser Lys Tyr Gln Glu 
    370                 375                 380                 


Asp Thr Cys Tyr Gly Asp Ala Gly Ser Ala Phe Ala Val His Asp Leu 
385                 390                 395                 400 


Glu Glu Asp Thr Trp Tyr Ala Thr Gly Ile Leu Ser Phe Asp Lys Ser 
                405                 410                 415     


Cys Ala Val Ala Glu Tyr Gly Val Tyr Val Lys Val Thr Ser Ile Gln 
            420                 425                 430         


Asp Trp Val Gln Lys Thr Ile Ala Glu Asn 
        435                 440         


<210>  6532
<211>  406
<212>  PRT
<213>  Homo Sapiens

<400>  6532

Met Ser Ala Leu Gly Ala Val Ile Ala Leu Leu Leu Trp Gly Gln Leu 
1               5                   10                  15      


Phe Ala Val Asp Ser Gly Asn Asp Val Thr Asp Ile Ala Asp Asp Gly 
            20                  25                  30          


Cys Pro Lys Pro Pro Glu Ile Ala His Gly Tyr Val Glu His Ser Val 
        35                  40                  45              


Arg Tyr Gln Cys Lys Asn Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Gly 
    50                  55                  60                  


Val Tyr Thr Leu Asn Asp Lys Lys Gln Trp Ile Asn Lys Ala Val Gly 
65                  70                  75                  80  


Asp Lys Leu Pro Glu Cys Glu Ala Asp Asp Gly Cys Pro Lys Pro Pro 
                85                  90                  95      


Glu Ile Ala His Gly Tyr Val Glu His Ser Val Arg Tyr Gln Cys Lys 
            100                 105                 110         


Asn Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Gly Val Tyr Thr Leu Asn 
        115                 120                 125             


Asn Glu Lys Gln Trp Ile Asn Lys Ala Val Gly Asp Lys Leu Pro Glu 
    130                 135                 140                 


Cys Glu Ala Val Cys Gly Lys Pro Lys Asn Pro Ala Asn Pro Val Gln 
145                 150                 155                 160 


Arg Ile Leu Gly Gly His Leu Asp Ala Lys Gly Ser Phe Pro Trp Gln 
                165                 170                 175     


Ala Lys Met Val Ser His His Asn Leu Thr Thr Gly Ala Thr Leu Ile 
            180                 185                 190         


Asn Glu Gln Trp Leu Leu Thr Thr Ala Lys Asn Leu Phe Leu Asn His 
        195                 200                 205             


Ser Glu Asn Ala Thr Ala Lys Asp Ile Ala Pro Thr Leu Thr Leu Tyr 
    210                 215                 220                 


Val Gly Lys Lys Gln Leu Val Glu Ile Glu Lys Val Val Leu His Pro 
225                 230                 235                 240 


Asn Tyr Ser Gln Val Asp Ile Gly Leu Ile Lys Leu Lys Gln Lys Val 
                245                 250                 255     


Ser Val Asn Glu Arg Val Met Pro Ile Cys Leu Pro Ser Lys Asp Tyr 
            260                 265                 270         


Ala Glu Val Gly Arg Val Gly Tyr Val Ser Gly Trp Gly Arg Asn Ala 
        275                 280                 285             


Asn Phe Lys Phe Thr Asp His Leu Lys Tyr Val Met Leu Pro Val Ala 
    290                 295                 300                 


Asp Gln Asp Gln Cys Ile Arg His Tyr Glu Gly Ser Thr Val Pro Glu 
305                 310                 315                 320 


Lys Lys Thr Pro Lys Ser Pro Val Gly Val Gln Pro Ile Leu Asn Glu 
                325                 330                 335     


His Thr Phe Cys Ala Gly Met Ser Lys Tyr Gln Glu Asp Thr Cys Tyr 
            340                 345                 350         


Gly Asp Ala Gly Ser Ala Phe Ala Val His Asp Leu Glu Glu Asp Thr 
        355                 360                 365             


Trp Tyr Ala Thr Gly Ile Leu Ser Phe Asp Lys Ser Cys Ala Val Ala 
    370                 375                 380                 


Glu Tyr Gly Val Tyr Val Lys Val Thr Ser Ile Gln Asp Trp Val Gln 
385                 390                 395                 400 


Lys Thr Ile Ala Glu Asn 
                405     


<210>  6533
<211>  347
<212>  PRT
<213>  Homo Sapiens

<400>  6533

Met Ser Ala Leu Gly Ala Val Ile Ala Leu Leu Leu Trp Gly Gln Leu 
1               5                   10                  15      


Phe Ala Val Asp Ser Gly Asn Asp Val Thr Asp Ile Ala Asp Asp Gly 
            20                  25                  30          


Cys Pro Lys Pro Pro Glu Ile Ala His Gly Tyr Val Glu His Ser Val 
        35                  40                  45              


Arg Tyr Gln Cys Lys Asn Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Gly 
    50                  55                  60                  


Val Tyr Thr Leu Asn Asp Lys Lys Gln Trp Ile Asn Lys Ala Val Gly 
65                  70                  75                  80  


Asp Lys Leu Pro Glu Cys Glu Ala Val Cys Gly Lys Pro Lys Asn Pro 
                85                  90                  95      


Ala Asn Pro Val Gln Arg Ile Leu Gly Gly His Leu Asp Ala Lys Gly 
            100                 105                 110         


Ser Phe Pro Trp Gln Ala Lys Met Val Ser His His Asn Leu Thr Thr 
        115                 120                 125             


Gly Ala Thr Leu Ile Asn Glu Gln Trp Leu Leu Thr Thr Ala Lys Asn 
    130                 135                 140                 


Leu Phe Leu Asn His Ser Glu Asn Ala Thr Ala Lys Asp Ile Ala Pro 
145                 150                 155                 160 


Thr Leu Thr Leu Tyr Val Gly Lys Lys Gln Leu Val Glu Ile Glu Lys 
                165                 170                 175     


Val Val Leu His Pro Asn Tyr Ser Gln Val Asp Ile Gly Leu Ile Lys 
            180                 185                 190         


Leu Lys Gln Lys Val Ser Val Asn Glu Arg Val Met Pro Ile Cys Leu 
        195                 200                 205             


Pro Ser Lys Asp Tyr Ala Glu Val Gly Arg Val Gly Tyr Val Ser Gly 
    210                 215                 220                 


Trp Gly Arg Asn Ala Asn Phe Lys Phe Thr Asp His Leu Lys Tyr Val 
225                 230                 235                 240 


Met Leu Pro Val Ala Asp Gln Asp Gln Cys Ile Arg His Tyr Glu Gly 
                245                 250                 255     


Ser Thr Val Pro Glu Lys Lys Thr Pro Lys Ser Pro Val Gly Val Gln 
            260                 265                 270         


Pro Ile Leu Asn Glu His Thr Phe Cys Ala Gly Met Ser Lys Tyr Gln 
        275                 280                 285             


Glu Asp Thr Cys Tyr Gly Asp Ala Gly Ser Ala Phe Ala Val His Asp 
    290                 295                 300                 


Leu Glu Glu Asp Thr Trp Tyr Ala Thr Gly Ile Leu Ser Phe Asp Lys 
305                 310                 315                 320 


Ser Cys Ala Val Ala Glu Tyr Gly Val Tyr Val Lys Val Thr Ser Ile 
                325                 330                 335     


Gln Asp Trp Val Gln Lys Thr Ile Ala Glu Asn 
            340                 345         


<210>  6534
<211>  88
<212>  PRT
<213>  Homo Sapiens

<400>  6534

Met Ser Ala Leu Gly Ala Val Ile Ala Leu Leu Leu Trp Gly Gln Leu 
1               5                   10                  15      


Phe Ala Val Asp Ser Gly Asn Asp Val Thr Asp Ile Ala Asp Asp Gly 
            20                  25                  30          


Cys Pro Lys Pro Pro Glu Ile Ala His Gly Tyr Val Glu His Ser Val 
        35                  40                  45              


Arg Tyr Gln Cys Lys Asn Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Gly 
    50                  55                  60                  


Val Tyr Thr Leu Asn Asn Glu Lys Gln Trp Ile Asn Lys Ala Val Gly 
65                  70                  75                  80  


Asp Lys Leu Pro Glu Cys Glu Ala 
                85              


<210>  6535
<211>  92
<212>  PRT
<213>  Homo Sapiens

<400>  6535

Met Ser Ala Leu Gly Ala Val Ile Ala Leu Leu Leu Trp Gly Gln Leu 
1               5                   10                  15      


Phe Ala Val Asp Ser Gly Asn Asp Val Thr Asp Ile Ala Asp Asp Gly 
            20                  25                  30          


Cys Pro Lys Pro Pro Glu Ile Ala His Gly Tyr Val Glu His Ser Val 
        35                  40                  45              


Arg Tyr Gln Cys Lys Asn Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Gly 
    50                  55                  60                  


Val Tyr Thr Leu Asn Asn Glu Lys Gln Trp Ile Asn Lys Ala Val Gly 
65                  70                  75                  80  


Asp Lys Leu Pro Glu Cys Glu Ala Ala His Thr Glu 
                85                  90          


<210>  6536
<211>  222
<212>  PRT
<213>  Homo Sapiens

<400>  6536

Met Ser Ala Leu Gly Ala Val Ile Ala Leu Leu Leu Trp Gly Gln Leu 
1               5                   10                  15      


Phe Ala Val Asp Ser Gly Asn Asp Val Thr Asp Ile Ala Asp Asp Gly 
            20                  25                  30          


Cys Pro Lys Pro Pro Glu Ile Ala His Gly Tyr Val Glu His Ser Val 
        35                  40                  45              


Arg Tyr Gln Cys Lys Asn Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Gly 
    50                  55                  60                  


Val Tyr Thr Leu Asn Asn Glu Lys Gln Trp Ile Asn Lys Ala Val Gly 
65                  70                  75                  80  


Asp Lys Leu Pro Glu Cys Glu Ala Gly Ala Thr Leu Ile Asn Glu Gln 
                85                  90                  95      


Trp Leu Leu Thr Thr Ala Lys Asn Leu Phe Leu Asn His Ser Glu Asn 
            100                 105                 110         


Ala Thr Ala Lys Asp Ile Ala Pro Thr Leu Thr Leu Tyr Val Gly Lys 
        115                 120                 125             


Lys Gln Leu Val Glu Ile Glu Lys Val Val Leu His Pro Asn Tyr Ser 
    130                 135                 140                 


Gln Val Asp Ile Gly Leu Ile Lys Leu Lys Gln Lys Val Ser Val Asn 
145                 150                 155                 160 


Glu Arg Val Met Pro Ile Cys Leu Pro Ser Lys Asp Tyr Ala Glu Val 
                165                 170                 175     


Gly Arg Val Gly Tyr Val Ser Gly Trp Gly Arg Asn Ala Asn Phe Lys 
            180                 185                 190         


Phe Thr Asp His Leu Lys Tyr Val Met Leu Pro Val Ala Asp Gln Asp 
        195                 200                 205             


Gln Cys Ile Arg His Tyr Glu Gly Ser Thr Val Pro Glu Lys 
    210                 215                 220         


<210>  6537
<211>  91
<212>  PRT
<213>  Homo Sapiens

<400>  6537

Met Ser Ala Leu Gly Ala Val Ile Ala Leu Leu Leu Trp Gly Gln Leu 
1               5                   10                  15      


Phe Ala Val Asp Ser Gly Asn Asp Val Thr Asp Ile Ala Asp Asp Gly 
            20                  25                  30          


Cys Pro Lys Pro Pro Glu Ile Ala His Gly Tyr Val Glu His Ser Val 
        35                  40                  45              


Arg Tyr Gln Cys Lys Asn Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Gly 
    50                  55                  60                  


Val Tyr Thr Leu Asn Asn Glu Lys Gln Trp Ile Asn Lys Ala Val Gly 
65                  70                  75                  80  


Asp Lys Leu Pro Glu Cys Glu Ala Gly Gly Cys 
                85                  90      


<210>  6538
<211>  347
<212>  PRT
<213>  Homo Sapiens

<400>  6538

Met Ser Ala Leu Gly Ala Val Ile Ala Leu Leu Leu Trp Gly Gln Leu 
1               5                   10                  15      


Phe Ala Val Asp Ser Gly Asn Asp Val Thr Asp Ile Ala Asp Asp Gly 
            20                  25                  30          


Cys Pro Lys Pro Pro Glu Ile Ala His Gly Tyr Val Glu His Ser Val 
        35                  40                  45              


Arg Tyr Gln Cys Lys Asn Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Gly 
    50                  55                  60                  


Val Tyr Thr Leu Asn Asn Glu Lys Gln Trp Ile Asn Lys Ala Val Gly 
65                  70                  75                  80  


Asp Lys Leu Pro Glu Cys Glu Ala Val Cys Gly Lys Pro Lys Asn Pro 
                85                  90                  95      


Ala Asn Pro Val Gln Arg Ile Leu Gly Gly His Leu Asp Ala Lys Gly 
            100                 105                 110         


Ser Phe Pro Trp Gln Ala Lys Met Val Ser His His Asn Leu Thr Thr 
        115                 120                 125             


Gly Ala Thr Leu Ile Asn Glu Gln Trp Leu Leu Thr Thr Ala Lys Asn 
    130                 135                 140                 


Leu Phe Leu Asn His Ser Glu Asn Ala Thr Ala Lys Asp Ile Ala Pro 
145                 150                 155                 160 


Thr Leu Thr Leu Tyr Val Gly Lys Lys Gln Leu Val Glu Ile Glu Lys 
                165                 170                 175     


Val Val Leu His Pro Asn Tyr Ser Gln Val Asp Ile Gly Leu Ile Lys 
            180                 185                 190         


Leu Lys Gln Lys Val Ser Val Asn Glu Arg Val Met Pro Ile Cys Leu 
        195                 200                 205             


Pro Ser Lys Asp Tyr Ala Glu Val Gly Arg Val Gly Tyr Val Ser Gly 
    210                 215                 220                 


Trp Gly Arg Asn Ala Asn Phe Lys Phe Thr Asp His Leu Lys Tyr Val 
225                 230                 235                 240 


Met Leu Pro Val Ala Asp Gln Asp Gln Cys Ile Arg His Tyr Glu Gly 
                245                 250                 255     


Ser Thr Val Pro Glu Lys Lys Thr Pro Lys Ser Pro Val Gly Val Gln 
            260                 265                 270         


Pro Ile Leu Asn Glu His Thr Phe Cys Ala Gly Met Ser Lys Tyr Gln 
        275                 280                 285             


Glu Asp Thr Cys Tyr Gly Asp Ala Gly Ser Ala Phe Ala Val His Asp 
    290                 295                 300                 


Leu Glu Glu Asp Thr Trp Tyr Ala Thr Gly Ile Leu Ser Phe Asp Lys 
305                 310                 315                 320 


Ser Cys Ala Val Ala Glu Tyr Gly Val Tyr Val Lys Val Thr Ser Ile 
                325                 330                 335     


Gln Asp Trp Val Gln Lys Thr Ile Ala Glu Asn 
            340                 345         


<210>  6539
<211>  347
<212>  PRT
<213>  Homo Sapiens

<400>  6539

Met Ser Ala Leu Gly Ala Val Ile Ala Leu Leu Leu Trp Gly Gln Leu 
1               5                   10                  15      


Phe Ala Val Asp Ser Gly Asn Asp Val Thr Asp Ile Ala Asp Asp Gly 
            20                  25                  30          


Cys Pro Lys Pro Pro Glu Ile Ala His Gly Tyr Val Glu His Ser Val 
        35                  40                  45              


Arg Tyr Gln Cys Lys Asn Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Gly 
    50                  55                  60                  


Val Tyr Thr Leu Asn Asn Glu Lys Gln Trp Ile Asn Lys Ala Val Gly 
65                  70                  75                  80  


Asp Lys Leu Pro Glu Cys Glu Ala Val Cys Gly Lys Pro Lys Asn Pro 
                85                  90                  95      


Ala Asn Pro Val Gln Arg Ile Leu Gly Gly His Leu Asp Ala Lys Gly 
            100                 105                 110         


Ser Phe Pro Trp Gln Ala Lys Met Val Ser His His Asn Leu Thr Thr 
        115                 120                 125             


Gly Ala Thr Leu Ile Asn Glu Gln Trp Leu Leu Thr Thr Ala Lys Asn 
    130                 135                 140                 


Leu Phe Leu Asn His Ser Glu Asn Ala Thr Ala Lys Asp Ile Ala Pro 
145                 150                 155                 160 


Thr Leu Thr Leu Tyr Val Gly Lys Lys Gln Leu Val Glu Ile Glu Lys 
                165                 170                 175     


Val Val Leu His Pro Asn Tyr Ser Gln Val Asp Ile Gly Leu Ile Lys 
            180                 185                 190         


Leu Lys Gln Lys Val Ser Val Asn Glu Arg Val Met Pro Ile Cys Leu 
        195                 200                 205             


Pro Ser Lys Asp Tyr Ala Glu Val Gly Arg Val Gly Tyr Val Ser Gly 
    210                 215                 220                 


Trp Gly Arg Asn Ala Asn Phe Lys Phe Thr Asp His Leu Lys Tyr Val 
225                 230                 235                 240 


Met Leu Pro Val Ala Asp Gln Asp Gln Cys Ile Arg His Tyr Glu Gly 
                245                 250                 255     


Ser Thr Val Pro Glu Lys Lys Thr Pro Lys Ser Pro Val Gly Val Gln 
            260                 265                 270         


Pro Ile Leu Asn Glu His Thr Phe Cys Ala Gly Met Ser Lys Tyr Gln 
        275                 280                 285             


Glu Asp Thr Cys Tyr Gly Asp Ala Gly Ser Ala Phe Ala Val His Asp 
    290                 295                 300                 


Leu Glu Glu Asp Thr Trp Tyr Ala Thr Gly Ile Leu Ser Phe Asp Lys 
305                 310                 315                 320 


Ser Cys Ala Val Ala Glu Tyr Gly Val Tyr Val Lys Val Thr Ser Ile 
                325                 330                 335     


Gln Asp Trp Val Gln Lys Thr Ile Ala Glu Asn 
            340                 345         


<210>  6540
<211>  281
<212>  PRT
<213>  Homo Sapiens

<400>  6540

Met Ser Arg Ile Ser Gln Met Thr Ala Ala Arg Ser Pro Pro Arg Leu 
1               5                   10                  15      


His Met Ala Met Trp Ser Thr Arg Phe Ala Thr Ser Val Arg Thr Asn 
            20                  25                  30          


Pro Val Gln Arg Ile Leu Gly Gly His Leu Asp Ala Lys Gly Ser Phe 
        35                  40                  45              


Pro Trp Gln Ala Lys Met Val Ser His His Asn Leu Thr Thr Gly Ala 
    50                  55                  60                  


Thr Leu Ile Asn Glu Gln Trp Leu Leu Thr Thr Ala Lys Asn Leu Phe 
65                  70                  75                  80  


Leu Asn His Ser Glu Asn Ala Thr Ala Lys Asp Ile Ala Pro Thr Leu 
                85                  90                  95      


Thr Leu Tyr Val Gly Lys Lys Gln Leu Val Glu Ile Glu Lys Val Val 
            100                 105                 110         


Leu His Pro Asn Tyr Ser Gln Val Asp Ile Gly Leu Ile Lys Leu Lys 
        115                 120                 125             


Gln Lys Val Ser Val Asn Glu Arg Val Met Pro Ile Cys Leu Pro Ser 
    130                 135                 140                 


Lys Asp Tyr Ala Glu Val Gly Arg Val Gly Tyr Val Ser Gly Trp Gly 
145                 150                 155                 160 


Arg Asn Ala Asn Phe Lys Phe Thr Asp His Leu Lys Tyr Val Met Leu 
                165                 170                 175     


Pro Val Ala Asp Gln Asp Gln Cys Ile Arg His Tyr Glu Gly Ser Thr 
            180                 185                 190         


Val Pro Glu Lys Lys Thr Pro Lys Ser Pro Val Gly Val Gln Pro Ile 
        195                 200                 205             


Leu Asn Glu His Thr Phe Cys Ala Gly Met Ser Lys Tyr Gln Glu Asp 
    210                 215                 220                 


Thr Cys Tyr Gly Asp Ala Gly Ser Ala Phe Ala Val His Asp Leu Glu 
225                 230                 235                 240 


Glu Asp Thr Trp Tyr Ala Thr Gly Ile Leu Ser Phe Asp Lys Ser Cys 
                245                 250                 255     


Ala Val Ala Glu Tyr Gly Val Tyr Val Lys Val Thr Ser Ile Gln Asp 
            260                 265                 270         


Trp Val Gln Lys Thr Ile Ala Glu Asn 
        275                 280     


<210>  6541
<211>  281
<212>  PRT
<213>  Homo Sapiens

<400>  6541

Met Ser Arg Ile Ser Gln Met Thr Ala Ala Arg Ser Pro Pro Arg Leu 
1               5                   10                  15      


His Met Ala Met Trp Ser Thr Arg Phe Ala Thr Ser Val Arg Thr Asn 
            20                  25                  30          


Pro Val Gln Arg Ile Leu Gly Gly His Leu Asp Ala Lys Gly Ser Phe 
        35                  40                  45              


Pro Trp Gln Ala Lys Met Val Ser His His Asn Leu Thr Thr Gly Ala 
    50                  55                  60                  


Thr Leu Ile Asn Glu Gln Trp Leu Leu Thr Thr Ala Lys Asn Leu Phe 
65                  70                  75                  80  


Leu Asn His Ser Glu Asn Ala Thr Ala Lys Asp Ile Ala Pro Thr Leu 
                85                  90                  95      


Thr Leu Tyr Val Gly Lys Lys Gln Leu Val Glu Ile Glu Lys Val Val 
            100                 105                 110         


Leu His Pro Asn Tyr Ser Gln Val Asp Ile Gly Leu Ile Lys Leu Lys 
        115                 120                 125             


Gln Lys Val Ser Val Asn Glu Arg Val Met Pro Ile Cys Leu Pro Ser 
    130                 135                 140                 


Lys Asp Tyr Ala Glu Val Gly Arg Val Gly Tyr Val Ser Gly Trp Gly 
145                 150                 155                 160 


Arg Asn Ala Asn Phe Lys Phe Thr Asp His Leu Lys Tyr Val Met Leu 
                165                 170                 175     


Pro Val Ala Asp Gln Asp Gln Cys Ile Arg His Tyr Glu Gly Ser Thr 
            180                 185                 190         


Val Pro Glu Lys Lys Thr Pro Lys Ser Pro Val Gly Val Gln Pro Ile 
        195                 200                 205             


Leu Asn Glu His Thr Phe Cys Ala Gly Met Ser Lys Tyr Gln Glu Asp 
    210                 215                 220                 


Thr Cys Tyr Gly Asp Ala Gly Ser Ala Phe Ala Val His Asp Leu Glu 
225                 230                 235                 240 


Glu Asp Thr Trp Tyr Ala Thr Gly Ile Leu Ser Phe Asp Lys Ser Cys 
                245                 250                 255     


Ala Val Ala Glu Tyr Gly Val Tyr Val Lys Val Thr Ser Ile Gln Asp 
            260                 265                 270         


Trp Val Gln Lys Thr Ile Ala Glu Asn 
        275                 280     


<210>  6542
<211>  365
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6542

Xaa Ala Leu Gly Ala Val Ile Ala Leu Leu Leu Trp Gly Gln Leu Phe 
1               5                   10                  15      


Ala Val Asp Ser Gly Asn Asp Val Thr Asp Ile Ala Asp Asp Gly Cys 
            20                  25                  30          


Pro Lys Pro Pro Glu Ile Ala His Gly Tyr Val Glu His Ser Val Arg 
        35                  40                  45              


Tyr Gln Cys Lys Asn Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Gly Val 
    50                  55                  60                  


Tyr Thr Leu Asn Asp Lys Lys Gln Trp Ile Asn Lys Ala Val Gly Asp 
65                  70                  75                  80  


Lys Leu Pro Glu Cys Glu Ala Asp Asp Gly Cys Pro Lys Pro Pro Glu 
                85                  90                  95      


Ile Ala His Gly Tyr Val Glu His Ser Val Arg Tyr Gln Cys Lys Asn 
            100                 105                 110         


Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Gly Val Tyr Thr Leu Asn Asn 
        115                 120                 125             


Glu Lys Gln Trp Ile Asn Lys Ala Val Gly Asp Lys Leu Pro Glu Cys 
    130                 135                 140                 


Glu Ala Gly Ala Thr Leu Ile Asn Glu Gln Trp Leu Leu Thr Thr Ala 
145                 150                 155                 160 


Lys Asn Leu Phe Leu Asn His Ser Glu Asn Ala Thr Ala Lys Asp Ile 
                165                 170                 175     


Ala Pro Thr Leu Thr Leu Tyr Val Gly Lys Lys Gln Leu Val Glu Ile 
            180                 185                 190         


Glu Lys Val Val Leu His Pro Asn Tyr Ser Gln Val Asp Ile Gly Leu 
        195                 200                 205             


Ile Lys Leu Lys Gln Lys Val Ser Val Asn Glu Arg Val Met Pro Ile 
    210                 215                 220                 


Cys Leu Pro Ser Lys Asp Tyr Ala Glu Val Gly Arg Val Gly Tyr Val 
225                 230                 235                 240 


Ser Gly Trp Gly Arg Asn Ala Asn Phe Lys Phe Thr Asp His Leu Lys 
                245                 250                 255     


Tyr Val Met Leu Pro Val Ala Asp Gln Asp Gln Cys Ile Arg His Tyr 
            260                 265                 270         


Glu Gly Ser Thr Val Pro Glu Lys Lys Thr Pro Lys Ser Pro Val Gly 
        275                 280                 285             


Val Gln Pro Ile Leu Asn Glu His Thr Phe Cys Ala Gly Met Ser Lys 
    290                 295                 300                 


Tyr Gln Glu Asp Thr Cys Tyr Gly Asp Ala Gly Ser Ala Phe Ala Val 
305                 310                 315                 320 


His Asp Leu Glu Glu Asp Thr Trp Tyr Ala Thr Gly Ile Leu Ser Phe 
                325                 330                 335     


Asp Lys Ser Cys Ala Val Ala Glu Tyr Gly Val Tyr Val Lys Val Thr 
            340                 345                 350         


Ser Ile Gln Asp Trp Val Gln Lys Thr Ile Ala Glu Asn 
        355                 360                 365 


<210>  6543
<211>  149
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6543

Xaa Ala Leu Gly Ala Val Ile Ala Leu Leu Leu Trp Gly Gln Leu Phe 
1               5                   10                  15      


Ala Val Asp Ser Gly Asn Asp Val Thr Asp Ile Ala Asp Asp Gly Cys 
            20                  25                  30          


Pro Lys Pro Pro Glu Ile Ala His Gly Tyr Val Glu His Ser Val Arg 
        35                  40                  45              


Tyr Gln Cys Lys Asn Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Gly Val 
    50                  55                  60                  


Tyr Thr Leu Asn Asp Lys Lys Gln Trp Ile Asn Lys Ala Val Gly Asp 
65                  70                  75                  80  


Lys Leu Pro Glu Cys Glu Ala Asp Asp Gly Cys Pro Lys Pro Pro Glu 
                85                  90                  95      


Ile Ala His Gly Tyr Val Glu His Ser Val Arg Tyr Gln Cys Lys Asn 
            100                 105                 110         


Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Gly Val Tyr Thr Leu Asn Asn 
        115                 120                 125             


Glu Lys Gln Trp Ile Asn Lys Ala Val Gly Asp Lys Leu Pro Glu Cys 
    130                 135                 140                 


Glu Ala Gly Gly Cys 
145                 


<210>  6544
<211>  404
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6544

Xaa Ala Leu Gly Ala Val Ile Ala Leu Leu Leu Trp Gly Gln Leu Phe 
1               5                   10                  15      


Ala Val Asp Ser Gly Asn Asp Val Thr Asp Ile Ala Asp Asp Gly Cys 
            20                  25                  30          


Pro Lys Pro Pro Glu Ile Ala His Gly Tyr Val Glu His Ser Val Arg 
        35                  40                  45              


Tyr Gln Cys Lys Asn Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Gly Val 
    50                  55                  60                  


Tyr Thr Leu Asn Asp Lys Lys Gln Trp Ile Asn Lys Ala Val Gly Asp 
65                  70                  75                  80  


Lys Leu Pro Glu Cys Glu Ala Asp Asp Gly Cys Pro Lys Pro Pro Glu 
                85                  90                  95      


Ile Ala His Gly Tyr Val Glu His Ser Val Arg Tyr Gln Cys Lys Asn 
            100                 105                 110         


Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Val Tyr Thr Leu Asn Asn Glu 
        115                 120                 125             


Lys Gln Trp Ile Asn Lys Ala Val Gly Asp Lys Leu Pro Glu Cys Glu 
    130                 135                 140                 


Ala Val Cys Gly Lys Pro Lys Asn Pro Ala Asn Pro Val Gln Arg Ile 
145                 150                 155                 160 


Leu Gly Gly His Leu Asp Ala Lys Gly Ser Phe Pro Trp Gln Ala Lys 
                165                 170                 175     


Met Val Ser His His Asn Leu Thr Thr Gly Ala Thr Leu Ile Asn Glu 
            180                 185                 190         


Gln Trp Leu Leu Thr Thr Ala Lys Asn Leu Phe Leu Asn His Ser Glu 
        195                 200                 205             


Asn Ala Thr Ala Lys Asp Ile Ala Pro Thr Leu Thr Leu Tyr Val Gly 
    210                 215                 220                 


Lys Lys Gln Leu Val Glu Ile Glu Lys Val Val Leu His Pro Asn Tyr 
225                 230                 235                 240 


Ser Gln Val Asp Ile Gly Leu Ile Lys Leu Lys Gln Lys Val Ser Val 
                245                 250                 255     


Asn Glu Arg Val Met Pro Ile Cys Leu Pro Ser Lys Asp Tyr Ala Glu 
            260                 265                 270         


Val Gly Arg Val Gly Tyr Val Ser Gly Trp Gly Arg Asn Ala Asn Phe 
        275                 280                 285             


Lys Phe Thr Asp His Leu Lys Tyr Val Met Leu Pro Val Ala Asp Gln 
    290                 295                 300                 


Asp Gln Cys Ile Arg His Tyr Glu Gly Ser Thr Val Pro Glu Lys Lys 
305                 310                 315                 320 


Thr Pro Lys Ser Pro Val Gly Val Gln Pro Ile Leu Asn Glu His Thr 
                325                 330                 335     


Phe Cys Ala Gly Met Ser Lys Tyr Gln Glu Asp Thr Cys Tyr Gly Asp 
            340                 345                 350         


Ala Gly Ser Ala Phe Ala Val His Asp Leu Glu Glu Asp Thr Trp Tyr 
        355                 360                 365             


Ala Thr Gly Ile Leu Ser Phe Asp Lys Ser Cys Ala Val Ala Glu Tyr 
    370                 375                 380                 


Gly Val Tyr Val Lys Val Thr Ser Ile Gln Asp Trp Val Gln Lys Thr 
385                 390                 395                 400 


Ile Ala Glu Asn 
                


<210>  6545
<211>  348
<212>  PRT
<213>  Homo Sapiens

<400>  6545

Met Ser Asp Leu Gly Ala Val Ile Ser Leu Leu Leu Trp Gly Arg Gln 
1               5                   10                  15      


Leu Phe Ala Leu Tyr Ser Gly Asn Asp Val Thr Asp Ile Ser Asp Asp 
            20                  25                  30          


Arg Phe Pro Lys Pro Pro Glu Ile Ala Asn Gly Tyr Val Glu His Leu 
        35                  40                  45              


Phe Arg Tyr Gln Cys Lys Asn Tyr Tyr Arg Leu Arg Thr Glu Gly Asp 
    50                  55                  60                  


Gly Val Tyr Thr Leu Asn Asp Lys Lys Gln Trp Ile Asn Lys Ala Val 
65                  70                  75                  80  


Gly Asp Lys Leu Pro Glu Cys Glu Ala Val Cys Gly Lys Pro Lys Asn 
                85                  90                  95      


Pro Ala Asn Pro Val Gln Arg Ile Leu Gly Gly His Leu Asp Ala Lys 
            100                 105                 110         


Gly Ser Phe Pro Trp Gln Ala Lys Met Val Ser His His Asn Leu Thr 
        115                 120                 125             


Thr Gly Ala Thr Leu Ile Asn Glu Gln Trp Leu Leu Thr Thr Ala Lys 
    130                 135                 140                 


Asn Leu Phe Leu Asn His Ser Glu Asn Ala Thr Ala Lys Asp Ile Ala 
145                 150                 155                 160 


Pro Thr Leu Thr Leu Tyr Val Gly Lys Lys Gln Leu Val Glu Ile Glu 
                165                 170                 175     


Lys Val Val Leu His Pro Asn Tyr His Gln Val Asp Ile Gly Leu Ile 
            180                 185                 190         


Lys Leu Lys Gln Lys Val Leu Val Asn Glu Arg Val Met Pro Ile Cys 
        195                 200                 205             


Leu Pro Ser Lys Asn Tyr Ala Glu Val Gly Arg Val Gly Tyr Val Ser 
    210                 215                 220                 


Gly Trp Gly Gln Ser Asp Asn Phe Lys Leu Thr Asp His Leu Lys Tyr 
225                 230                 235                 240 


Val Met Leu Pro Val Ala Asp Gln Tyr Asp Cys Ile Thr His Tyr Glu 
                245                 250                 255     


Gly Ser Thr Cys Pro Lys Trp Lys Ala Pro Lys Ser Pro Val Gly Val 
            260                 265                 270         


Gln Pro Ile Leu Asn Glu His Thr Phe Cys Val Gly Met Ser Lys Tyr 
        275                 280                 285             


Gln Glu Asp Thr Cys Tyr Gly Asp Ala Gly Ser Ala Phe Ala Val His 
    290                 295                 300                 


Asp Leu Glu Glu Asp Thr Trp Tyr Ala Ala Gly Ile Leu Ser Phe Asp 
305                 310                 315                 320 


Lys Ser Cys Ala Val Ala Glu Tyr Gly Val Tyr Val Lys Val Thr Ser 
                325                 330                 335     


Ile Gln His Trp Val Gln Lys Thr Ile Ala Glu Asn 
            340                 345             


<210>  6546
<211>  117
<212>  PRT
<213>  Homo Sapiens

<400>  6546

Met Ser Asp Leu Gly Ala Val Ile Ser Leu Leu Leu Trp Gly Arg Gln 
1               5                   10                  15      


Leu Phe Ala Leu Tyr Ser Gly Asn Asp Val Thr Asp Ile Ser Asp Asp 
            20                  25                  30          


Arg Phe Pro Lys Pro Pro Glu Ile Ala Asn Gly Tyr Val Glu His Leu 
        35                  40                  45              


Phe Arg Tyr Gln Cys Lys Asn Tyr Tyr Arg Leu Arg Thr Glu Gly Asp 
    50                  55                  60                  


Gly Val Tyr Thr Leu Asn Asp Lys Lys Gln Trp Ile Asn Lys Ala Val 
65                  70                  75                  80  


Gly Asp Lys Leu Pro Glu Cys Glu Ala Val Cys Gly Lys Pro Lys Asn 
                85                  90                  95      


Pro Ala Asn Pro Val Gln Arg Ile Leu Gly Gly His Leu Val Arg Gly 
            100                 105                 110         


Trp Asp Pro Lys Leu 
        115         


<210>  6547
<211>  281
<212>  PRT
<213>  Homo Sapiens

<400>  6547

Met Ser Arg Ile Phe Gln Met Thr Ala Ser Arg Ser Pro Leu Arg Leu 
1               5                   10                  15      


Gln Met Ala Met Trp Ser Thr Cys Phe Ala Thr Ser Val Arg Thr Asn 
            20                  25                  30          


Pro Val Gln Arg Ile Leu Gly Gly His Leu Asp Ala Lys Gly Ser Phe 
        35                  40                  45              


Pro Trp Gln Ala Lys Met Val Ser His His Asn Leu Thr Thr Gly Ala 
    50                  55                  60                  


Thr Leu Ile Asn Glu Gln Trp Leu Leu Thr Thr Ala Lys Asn Leu Phe 
65                  70                  75                  80  


Leu Asn His Ser Glu Asn Ala Thr Ala Lys Asp Ile Ala Pro Thr Leu 
                85                  90                  95      


Thr Leu Tyr Val Gly Lys Lys Gln Leu Val Glu Ile Glu Lys Val Val 
            100                 105                 110         


Leu His Pro Asn Tyr His Gln Val Asp Ile Gly Leu Ile Lys Leu Lys 
        115                 120                 125             


Gln Lys Val Leu Val Asn Glu Arg Val Met Pro Ile Cys Leu Pro Ser 
    130                 135                 140                 


Lys Asn Tyr Ala Glu Val Gly Arg Val Gly Tyr Val Ser Gly Trp Gly 
145                 150                 155                 160 


Gln Ser Asp Asn Phe Lys Leu Thr Asp His Leu Lys Tyr Val Met Leu 
                165                 170                 175     


Pro Val Ala Asp Gln Tyr Asp Cys Ile Thr His Tyr Glu Gly Ser Thr 
            180                 185                 190         


Cys Pro Lys Trp Lys Ala Pro Lys Ser Pro Val Gly Val Gln Pro Ile 
        195                 200                 205             


Leu Asn Glu His Thr Phe Cys Val Gly Met Ser Lys Tyr Gln Glu Asp 
    210                 215                 220                 


Thr Cys Tyr Gly Asp Ala Gly Ser Ala Phe Ala Val His Asp Leu Glu 
225                 230                 235                 240 


Glu Asp Thr Trp Tyr Ala Ala Gly Ile Leu Ser Phe Asp Lys Ser Cys 
                245                 250                 255     


Ala Val Ala Glu Tyr Gly Val Tyr Val Lys Val Thr Ser Ile Gln His 
            260                 265                 270         


Trp Val Gln Lys Thr Ile Ala Glu Asn 
        275                 280     


<210>  6548
<211>  485
<212>  PRT
<213>  Homo Sapiens

<400>  6548

Met Leu Leu Arg Ser Lys Pro Ala Leu Pro Pro Pro Leu Met Leu Leu 
1               5                   10                  15      


Leu Leu Gly Pro Leu Gly Pro Leu Ser Pro Gly Ala Leu Pro Arg Pro 
            20                  25                  30          


Ala Gln Ala Gln Asp Val Val Asp Leu Asp Phe Phe Thr Gln Glu Pro 
        35                  40                  45              


Leu His Leu Val Ser Pro Ser Phe Leu Ser Val Thr Ile Asp Ala Asn 
    50                  55                  60                  


Leu Ala Thr Asp Pro Arg Phe Leu Ile Leu Leu Gly Ser Pro Lys Leu 
65                  70                  75                  80  


Arg Thr Leu Ala Arg Gly Leu Ser Pro Ala Tyr Leu Arg Phe Gly Gly 
                85                  90                  95      


Thr Lys Thr Asp Phe Leu Ile Phe Asp Pro Lys Lys Glu Ser Thr Phe 
            100                 105                 110         


Glu Glu Arg Ser Tyr Trp Gln Ser Gln Val Asn Gln Asp Ile Cys Lys 
        115                 120                 125             


Tyr Gly Ser Ile Pro Pro Asp Val Glu Glu Lys Leu Arg Leu Glu Trp 
    130                 135                 140                 


Pro Tyr Gln Glu Gln Leu Leu Leu Arg Glu His Tyr Gln Lys Lys Phe 
145                 150                 155                 160 


Lys Asn Ser Thr Tyr Ser Lys Pro Asn Ser Phe Leu Lys Lys Ala Asp 
                165                 170                 175     


Ile Phe Ile Asn Gly Ser Gln Leu Gly Glu Asp Phe Ile Gln Leu His 
            180                 185                 190         


Lys Leu Leu Arg Lys Ser Thr Phe Lys Asn Ala Lys Leu Tyr Gly Pro 
        195                 200                 205             


Asp Val Gly Gln Pro Arg Arg Lys Thr Ala Lys Met Leu Lys Ser Phe 
    210                 215                 220                 


Leu Lys Ala Gly Gly Glu Val Ile Asp Ser Val Thr Trp His His Tyr 
225                 230                 235                 240 


Tyr Leu Asn Gly Arg Thr Ala Thr Lys Glu Asp Phe Leu Asn Pro Asp 
                245                 250                 255     


Val Leu Asp Ile Phe Ile Ser Ser Val Gln Lys Val Phe Gln Val Val 
            260                 265                 270         


Glu Ser Thr Arg Pro Gly Lys Lys Val Trp Leu Gly Glu Thr Ser Ser 
        275                 280                 285             


Ala Tyr Gly Gly Gly Ala Pro Leu Leu Ser Asp Thr Phe Ala Ala Gly 
    290                 295                 300                 


Phe Met Trp Leu Asp Lys Leu Gly Leu Ser Ala Arg Met Gly Ile Glu 
305                 310                 315                 320 


Val Val Met Arg Gln Val Phe Phe Gly Ala Gly Asn Tyr His Leu Val 
                325                 330                 335     


Asp Glu Asn Phe Asp Pro Leu Pro Asp Tyr Trp Leu Ser Leu Leu Phe 
            340                 345                 350         


Lys Lys Leu Val Gly Thr Lys Val Leu Met Ala Ser Val Gln Gly Ser 
        355                 360                 365             


Lys Arg Arg Lys Leu Arg Val Tyr Leu His Cys Thr Asn Thr Asp Asn 
    370                 375                 380                 


Pro Arg Tyr Lys Glu Gly Asp Leu Thr Leu Tyr Ala Ile Asn Leu His 
385                 390                 395                 400 


Asn Val Thr Lys Tyr Leu Arg Leu Pro Tyr Pro Phe Ser Asn Lys Gln 
                405                 410                 415     


Val Asp Lys Tyr Leu Leu Arg Pro Leu Gly Pro His Gly Leu Leu Ser 
            420                 425                 430         


Lys Ser Val Gln Leu Asn Gly Leu Thr Leu Lys Met Val Asp Asp Gln 
        435                 440                 445             


Thr Leu Pro Pro Leu Met Glu Lys Pro Leu Arg Pro Gly Ser Ser Leu 
    450                 455                 460                 


Gly Leu Pro Ala Phe Ser Tyr Ser Phe Phe Val Ile Arg Asn Ala Lys 
465                 470                 475                 480 


Val Ala Ala Cys Ile 
                485 


<210>  6549
<211>  226
<212>  PRT
<213>  Homo Sapiens

<400>  6549

Met Leu Leu Arg Ser Lys Pro Ala Leu Pro Pro Pro Leu Met Leu Leu 
1               5                   10                  15      


Leu Leu Gly Pro Leu Gly Pro Leu Ser Pro Gly Ala Leu Pro Arg Pro 
            20                  25                  30          


Ala Gln Ala Gln Asp Val Val Asp Leu Asp Phe Phe Thr Gln Glu Pro 
        35                  40                  45              


Leu His Leu Val Ser Pro Ser Phe Leu Ser Val Thr Ile Asp Ala Asn 
    50                  55                  60                  


Leu Ala Thr Asp Pro Arg Phe Leu Ile Leu Leu Gly Ser Pro Lys Leu 
65                  70                  75                  80  


Arg Thr Leu Ala Arg Gly Leu Ser Pro Ala Tyr Leu Arg Phe Gly Gly 
                85                  90                  95      


Thr Lys Thr Asp Phe Leu Ile Phe Asp Pro Lys Lys Glu Ser Thr Phe 
            100                 105                 110         


Glu Glu Arg Ser Tyr Trp Gln Ser Gln Val Asn Gln Asp Ile Cys Lys 
        115                 120                 125             


Tyr Gly Ser Ile Pro Pro Asp Val Glu Glu Lys Leu Arg Leu Glu Trp 
    130                 135                 140                 


Pro Tyr Gln Glu Gln Leu Leu Leu Arg Glu His Tyr Gln Lys Lys Phe 
145                 150                 155                 160 


Lys Asn Ser Thr Tyr Ser Arg Ser Ser Val Asp Val Leu Tyr Thr Phe 
                165                 170                 175     


Ala Asn Cys Ser Gly Leu Asp Leu Ile Phe Gly Leu Asn Ala Leu Leu 
            180                 185                 190         


Arg Thr Ala Asp Leu Gln Trp Asn Ser Ser Asn Ala Gln Leu Leu Leu 
        195                 200                 205             


Asp Tyr Cys Ser Ser Lys Gly Tyr Asn Ile Ser Trp Glu Leu Gly Asn 
    210                 215                 220                 


Ala Ser 
225     


<210>  6550
<211>  543
<212>  PRT
<213>  Homo Sapiens

<400>  6550

Met Leu Leu Arg Ser Lys Pro Ala Leu Pro Pro Pro Leu Met Leu Leu 
1               5                   10                  15      


Leu Leu Gly Pro Leu Gly Pro Leu Ser Pro Gly Ala Leu Pro Arg Pro 
            20                  25                  30          


Ala Gln Ala Gln Asp Val Val Asp Leu Asp Phe Phe Thr Gln Glu Pro 
        35                  40                  45              


Leu His Leu Val Ser Pro Ser Phe Leu Ser Val Thr Ile Asp Ala Asn 
    50                  55                  60                  


Leu Ala Thr Asp Pro Arg Phe Leu Ile Leu Leu Gly Ser Pro Lys Leu 
65                  70                  75                  80  


Arg Thr Leu Ala Arg Gly Leu Ser Pro Ala Tyr Leu Arg Phe Gly Gly 
                85                  90                  95      


Thr Lys Thr Asp Phe Leu Ile Phe Asp Pro Lys Lys Glu Ser Thr Phe 
            100                 105                 110         


Glu Glu Arg Ser Tyr Trp Gln Ser Gln Val Asn Gln Asp Ile Cys Lys 
        115                 120                 125             


Tyr Gly Ser Ile Pro Pro Asp Val Glu Glu Lys Leu Arg Leu Glu Trp 
    130                 135                 140                 


Pro Tyr Gln Glu Gln Leu Leu Leu Arg Glu His Tyr Gln Lys Lys Phe 
145                 150                 155                 160 


Lys Asn Ser Thr Tyr Ser Arg Ser Ser Val Asp Val Leu Tyr Thr Phe 
                165                 170                 175     


Ala Asn Cys Ser Gly Leu Asp Leu Ile Phe Gly Leu Asn Ala Leu Leu 
            180                 185                 190         


Arg Thr Ala Asp Leu Gln Trp Asn Ser Ser Asn Ala Gln Leu Leu Leu 
        195                 200                 205             


Asp Tyr Cys Ser Ser Lys Gly Tyr Asn Ile Ser Trp Glu Leu Gly Asn 
    210                 215                 220                 


Glu Pro Asn Ser Phe Leu Lys Lys Ala Asp Ile Phe Ile Asn Gly Ser 
225                 230                 235                 240 


Gln Leu Gly Glu Asp Phe Ile Gln Leu His Lys Leu Leu Arg Lys Ser 
                245                 250                 255     


Thr Phe Lys Asn Ala Lys Leu Tyr Gly Pro Asp Val Gly Gln Pro Arg 
            260                 265                 270         


Arg Lys Thr Ala Lys Met Leu Lys Ser Phe Leu Lys Ala Gly Gly Glu 
        275                 280                 285             


Val Ile Asp Ser Val Thr Trp His His Tyr Tyr Leu Asn Gly Arg Thr 
    290                 295                 300                 


Ala Thr Lys Glu Asp Phe Leu Asn Pro Asp Val Leu Asp Ile Phe Ile 
305                 310                 315                 320 


Ser Ser Val Gln Lys Val Phe Gln Val Val Glu Ser Thr Arg Pro Gly 
                325                 330                 335     


Lys Lys Val Trp Leu Gly Glu Thr Ser Ser Ala Tyr Gly Gly Gly Ala 
            340                 345                 350         


Pro Leu Leu Ser Asp Thr Phe Ala Ala Gly Phe Met Trp Leu Asp Lys 
        355                 360                 365             


Leu Gly Leu Ser Ala Arg Met Gly Ile Glu Val Val Met Arg Gln Val 
    370                 375                 380                 


Phe Phe Gly Ala Gly Asn Tyr His Leu Val Asp Glu Asn Phe Asp Pro 
385                 390                 395                 400 


Leu Pro Asp Tyr Trp Leu Ser Leu Leu Phe Lys Lys Leu Val Gly Thr 
                405                 410                 415     


Lys Val Leu Met Ala Ser Val Gln Gly Ser Lys Arg Arg Lys Leu Arg 
            420                 425                 430         


Val Tyr Leu His Cys Thr Asn Thr Asp Asn Pro Arg Tyr Lys Glu Gly 
        435                 440                 445             


Asp Leu Thr Leu Tyr Ala Ile Asn Leu His Asn Val Thr Lys Tyr Leu 
    450                 455                 460                 


Arg Leu Pro Tyr Pro Phe Ser Asn Lys Gln Val Asp Lys Tyr Leu Leu 
465                 470                 475                 480 


Arg Pro Leu Gly Pro His Gly Leu Leu Ser Lys Ser Val Gln Leu Asn 
                485                 490                 495     


Gly Leu Thr Leu Lys Met Val Asp Asp Gln Thr Leu Pro Pro Leu Met 
            500                 505                 510         


Glu Lys Pro Leu Arg Pro Gly Ser Ser Leu Gly Leu Pro Ala Phe Ser 
        515                 520                 525             


Tyr Ser Phe Phe Val Ile Arg Asn Ala Lys Val Ala Ala Cys Ile 
    530                 535                 540             


<210>  6551
<211>  543
<212>  PRT
<213>  Homo Sapiens

<400>  6551

Met Leu Leu Arg Ser Lys Pro Ala Leu Pro Pro Pro Leu Met Leu Leu 
1               5                   10                  15      


Leu Leu Gly Pro Leu Gly Pro Leu Ser Pro Gly Ala Leu Pro Arg Pro 
            20                  25                  30          


Ala Gln Ala Gln Asp Val Val Asp Leu Asp Phe Phe Thr Gln Glu Pro 
        35                  40                  45              


Leu His Leu Val Ser Pro Ser Phe Leu Ser Val Thr Ile Asp Ala Asn 
    50                  55                  60                  


Leu Ala Thr Asp Pro Arg Phe Leu Ile Leu Leu Gly Ser Pro Lys Leu 
65                  70                  75                  80  


Arg Thr Leu Ala Arg Gly Leu Ser Pro Ala Tyr Leu Arg Phe Gly Gly 
                85                  90                  95      


Thr Lys Thr Asp Phe Leu Ile Phe Asp Pro Lys Lys Glu Ser Thr Phe 
            100                 105                 110         


Glu Glu Arg Ser Tyr Trp Gln Ser Gln Val Asn Gln Asp Ile Cys Lys 
        115                 120                 125             


Tyr Gly Ser Ile Pro Pro Asp Val Glu Glu Lys Leu Arg Leu Glu Trp 
    130                 135                 140                 


Pro Tyr Gln Glu Gln Leu Leu Leu Arg Glu His Tyr Gln Lys Lys Phe 
145                 150                 155                 160 


Lys Asn Ser Thr Tyr Ser Arg Ser Ser Val Asp Val Leu Tyr Thr Phe 
                165                 170                 175     


Ala Asn Cys Ser Gly Leu Asp Leu Ile Phe Gly Leu Asn Ala Leu Leu 
            180                 185                 190         


Arg Thr Ala Asp Leu Gln Trp Asn Ser Ser Asn Ala Gln Leu Leu Leu 
        195                 200                 205             


Asp Tyr Cys Ser Ser Lys Gly Tyr Asn Ile Ser Trp Glu Leu Gly Asn 
    210                 215                 220                 


Glu Pro Asn Ser Phe Leu Lys Lys Ala Asp Ile Phe Ile Asn Gly Ser 
225                 230                 235                 240 


Gln Leu Gly Glu Asp Phe Ile Gln Leu His Lys Leu Leu Arg Lys Ser 
                245                 250                 255     


Thr Phe Lys Asn Ala Lys Leu Tyr Gly Pro Asp Val Gly Gln Pro Arg 
            260                 265                 270         


Arg Lys Thr Ala Lys Met Leu Lys Ser Phe Leu Lys Ala Gly Gly Glu 
        275                 280                 285             


Val Ile Asp Ser Val Thr Trp His His Tyr Tyr Leu Asn Gly Arg Thr 
    290                 295                 300                 


Ala Thr Lys Glu Asp Phe Leu Asn Pro Asp Val Leu Asp Ile Phe Ile 
305                 310                 315                 320 


Ser Ser Val Gln Lys Val Phe Gln Val Val Glu Ser Thr Arg Pro Gly 
                325                 330                 335     


Lys Lys Val Trp Leu Gly Glu Thr Ser Ser Ala Tyr Gly Gly Gly Ala 
            340                 345                 350         


Pro Leu Leu Ser Asp Thr Phe Ala Ala Gly Phe Met Trp Leu Asp Lys 
        355                 360                 365             


Leu Gly Leu Ser Ala Arg Met Gly Ile Glu Val Val Met Arg Gln Val 
    370                 375                 380                 


Phe Phe Gly Ala Gly Asn Tyr His Leu Val Asp Glu Asn Phe Asp Pro 
385                 390                 395                 400 


Leu Pro Asp Tyr Trp Leu Ser Leu Leu Phe Lys Lys Leu Val Gly Thr 
                405                 410                 415     


Lys Val Leu Met Ala Ser Val Gln Gly Ser Lys Arg Arg Lys Leu Arg 
            420                 425                 430         


Val Tyr Leu His Cys Thr Asn Thr Asp Asn Pro Arg Tyr Lys Glu Gly 
        435                 440                 445             


Asp Leu Thr Leu Tyr Ala Ile Asn Leu His Asn Val Thr Lys Tyr Leu 
    450                 455                 460                 


Arg Leu Pro Tyr Pro Phe Ser Asn Lys Gln Val Asp Lys Tyr Leu Leu 
465                 470                 475                 480 


Arg Pro Leu Gly Pro His Gly Leu Leu Ser Lys Ser Val Gln Leu Asn 
                485                 490                 495     


Gly Leu Thr Leu Lys Met Val Asp Asp Gln Thr Leu Pro Pro Leu Met 
            500                 505                 510         


Glu Lys Pro Leu Arg Pro Gly Ser Ser Leu Gly Leu Pro Ala Phe Ser 
        515                 520                 525             


Tyr Ser Phe Phe Val Ile Arg Asn Ala Lys Val Ala Ala Cys Ile 
    530                 535                 540             


<210>  6552
<211>  380
<212>  PRT
<213>  Homo Sapiens

<400>  6552

Met Leu Leu Arg Ser Lys Pro Ala Leu Pro Pro Pro Leu Met Leu Leu 
1               5                   10                  15      


Leu Leu Gly Pro Leu Gly Pro Leu Ser Pro Gly Ala Leu Pro Arg Pro 
            20                  25                  30          


Ala Gln Ala Gln Asp Val Val Asp Leu Asp Phe Phe Thr Gln Glu Pro 
        35                  40                  45              


Leu His Leu Val Ser Pro Ser Phe Leu Ser Val Thr Ile Asp Ala Asn 
    50                  55                  60                  


Leu Ala Thr Asp Pro Arg Phe Leu Ile Leu Leu Gly Ser Pro Lys Leu 
65                  70                  75                  80  


Arg Thr Leu Ala Arg Gly Leu Ser Pro Ala Tyr Leu Arg Phe Gly Gly 
                85                  90                  95      


Thr Lys Thr Asp Phe Leu Ile Phe Asp Pro Lys Lys Glu Ser Thr Phe 
            100                 105                 110         


Glu Glu Arg Ser Tyr Trp Gln Ser Gln Val Asn Gln Asp Ile Cys Lys 
        115                 120                 125             


Tyr Gly Ser Ile Pro Pro Asp Val Glu Glu Lys Leu Arg Leu Glu Trp 
    130                 135                 140                 


Pro Tyr Gln Glu Gln Leu Leu Leu Arg Glu His Tyr Gln Lys Lys Phe 
145                 150                 155                 160 


Lys Asn Ser Thr Tyr Ser Arg Ser Ser Val Asp Val Leu Tyr Thr Phe 
                165                 170                 175     


Ala Asn Cys Ser Gly Leu Asp Leu Ile Phe Gly Leu Asn Ala Leu Leu 
            180                 185                 190         


Arg Thr Ala Asp Leu Gln Trp Asn Ser Ser Asn Ala Gln Leu Leu Leu 
        195                 200                 205             


Asp Tyr Cys Ser Ser Lys Gly Tyr Asn Ile Ser Trp Glu Leu Gly Asn 
    210                 215                 220                 


Glu Pro Asn Ser Phe Leu Lys Lys Ala Asp Ile Phe Ile Asn Gly Ser 
225                 230                 235                 240 


Gln Leu Gly Glu Asp Phe Ile Gln Leu His Lys Leu Leu Arg Lys Ser 
                245                 250                 255     


Thr Phe Lys Asn Ala Lys Leu Tyr Gly Pro Asp Val Gly Gln Pro Arg 
            260                 265                 270         


Arg Lys Thr Ala Lys Met Leu Lys Ser Phe Leu Lys Ala Gly Gly Glu 
        275                 280                 285             


Val Ile Asp Ser Val Thr Trp His His Tyr Tyr Leu Asn Gly Arg Thr 
    290                 295                 300                 


Ala Thr Lys Glu Asp Phe Leu Asn Pro Asp Val Leu Asp Ile Phe Ile 
305                 310                 315                 320 


Ser Ser Val Gln Lys Val Phe Gln Val Val Glu Ser Thr Arg Pro Gly 
                325                 330                 335     


Lys Lys Val Trp Leu Gly Glu Thr Ser Ser Ala Tyr Gly Gly Gly Ala 
            340                 345                 350         


Pro Leu Leu Ser Asp Thr Phe Ala Ala Gly Phe Met Ile Ile Gly Tyr 
        355                 360                 365             


Leu Phe Cys Ser Arg Asn Trp Trp Ala Pro Arg Cys 
    370                 375                 380 


<210>  6553
<211>  469
<212>  PRT
<213>  Homo Sapiens

<400>  6553

Met Leu Leu Arg Ser Lys Pro Ala Leu Pro Pro Pro Leu Met Leu Leu 
1               5                   10                  15      


Leu Leu Gly Pro Leu Gly Pro Leu Ser Pro Gly Ala Leu Pro Arg Pro 
            20                  25                  30          


Ala Gln Ala Gln Asp Val Val Asp Leu Asp Phe Phe Thr Gln Glu Pro 
        35                  40                  45              


Leu His Leu Val Ser Pro Ser Phe Leu Ser Val Thr Ile Asp Ala Asn 
    50                  55                  60                  


Leu Ala Thr Asp Pro Arg Phe Leu Ile Leu Leu Gly Ser Pro Lys Leu 
65                  70                  75                  80  


Arg Thr Leu Ala Arg Gly Leu Ser Pro Ala Tyr Leu Arg Phe Gly Gly 
                85                  90                  95      


Thr Lys Thr Asp Phe Leu Ile Phe Asp Pro Lys Lys Glu Ser Thr Phe 
            100                 105                 110         


Glu Glu Arg Ser Tyr Trp Gln Ser Gln Val Asn Gln Asp Ile Cys Lys 
        115                 120                 125             


Tyr Gly Ser Ile Pro Pro Asp Val Glu Glu Lys Leu Arg Leu Glu Trp 
    130                 135                 140                 


Pro Tyr Gln Glu Gln Leu Leu Leu Arg Glu His Tyr Gln Lys Lys Phe 
145                 150                 155                 160 


Lys Asn Ser Thr Tyr Ser Arg Ser Ser Val Asp Val Leu Tyr Thr Phe 
                165                 170                 175     


Ala Asn Cys Ser Gly Leu Asp Leu Ile Phe Gly Leu Asn Ala Leu Leu 
            180                 185                 190         


Arg Thr Ala Asp Leu Gln Trp Asn Ser Ser Asn Ala Gln Leu Leu Leu 
        195                 200                 205             


Asp Tyr Cys Ser Ser Lys Gly Tyr Asn Ile Ser Trp Glu Leu Gly Asn 
    210                 215                 220                 


Glu Pro Asn Ser Phe Leu Lys Lys Ala Asp Ile Phe Ile Asn Gly Ser 
225                 230                 235                 240 


Gln Leu Gly Glu Asp Phe Ile Gln Leu His Lys Leu Leu Arg Lys Ser 
                245                 250                 255     


Thr Phe Lys Asn Ala Lys Leu Tyr Gly Pro Asp Val Gly Gln Pro Arg 
            260                 265                 270         


Arg Lys Thr Ala Lys Met Leu Lys Ser Phe Leu Lys Ala Gly Gly Glu 
        275                 280                 285             


Val Ile Asp Ser Val Thr Trp His His Tyr Tyr Leu Asn Gly Arg Thr 
    290                 295                 300                 


Ala Thr Lys Glu Asp Phe Leu Asn Pro Asp Val Leu Asp Ile Phe Ile 
305                 310                 315                 320 


Ser Ser Val Gln Lys Val Phe Gln Asp Tyr Trp Leu Ser Leu Leu Phe 
                325                 330                 335     


Lys Lys Leu Val Gly Thr Lys Val Leu Met Ala Ser Val Gln Gly Ser 
            340                 345                 350         


Lys Arg Arg Lys Leu Arg Val Tyr Leu His Cys Thr Asn Thr Asp Asn 
        355                 360                 365             


Pro Arg Tyr Lys Glu Gly Asp Leu Thr Leu Tyr Ala Ile Asn Leu His 
    370                 375                 380                 


Asn Val Thr Lys Tyr Leu Arg Leu Pro Tyr Pro Phe Ser Asn Lys Gln 
385                 390                 395                 400 


Val Asp Lys Tyr Leu Leu Arg Pro Leu Gly Pro His Gly Leu Leu Ser 
                405                 410                 415     


Lys Ser Val Gln Leu Asn Gly Leu Thr Leu Lys Met Val Asp Asp Gln 
            420                 425                 430         


Thr Leu Pro Pro Leu Met Glu Lys Pro Leu Arg Pro Gly Ser Ser Leu 
        435                 440                 445             


Gly Leu Pro Ala Phe Ser Tyr Ser Phe Phe Val Ile Arg Asn Ala Lys 
    450                 455                 460                 


Val Ala Ala Cys Ile 
465                 


<210>  6554
<211>  168
<212>  PRT
<213>  Homo Sapiens

<400>  6554

Met Leu Leu Arg Ser Lys Pro Ala Leu Pro Pro Pro Leu Met Leu Leu 
1               5                   10                  15      


Leu Leu Gly Pro Leu Gly Pro Leu Ser Pro Gly Ala Leu Pro Arg Pro 
            20                  25                  30          


Ala Gln Ala Gln Asp Val Val Asp Leu Asp Phe Phe Thr Gln Glu Pro 
        35                  40                  45              


Leu His Leu Val Ser Pro Ser Phe Leu Ser Val Thr Ile Asp Ala Asn 
    50                  55                  60                  


Leu Ala Thr Asp Pro Arg Phe Leu Ile Leu Leu Gly Ser Pro Lys Leu 
65                  70                  75                  80  


Arg Thr Leu Ala Arg Gly Leu Ser Pro Ala Tyr Leu Arg Phe Gly Gly 
                85                  90                  95      


Thr Lys Thr Asp Phe Leu Ile Phe Asp Pro Lys Lys Glu Ser Thr Phe 
            100                 105                 110         


Glu Glu Arg Ser Tyr Trp Gln Ser Gln Val Asn Gln Asp Ile Cys Lys 
        115                 120                 125             


Tyr Gly Ser Ile Pro Pro Asp Val Glu Glu Lys Leu Arg Leu Glu Trp 
    130                 135                 140                 


Pro Tyr Gln Glu Gln Leu Leu Leu Arg Glu His Tyr Gln Lys Lys Phe 
145                 150                 155                 160 


Lys Asn Ser Thr Tyr Ser Thr Ser 
                165             


<210>  6555
<211>  389
<212>  PRT
<213>  Homo Sapiens

<400>  6555

Ala Arg Ser Leu Asp Lys Leu Tyr Asn Phe Ala Asp Cys Ser Gly Leu 
1               5                   10                  15      


His Leu Ile Phe Ala Leu Asn Ala Leu Arg Arg Asn Pro Asn Asn Ser 
            20                  25                  30          


Trp Asn Ser Ser Ser Ala Leu Ser Leu Leu Lys Tyr Ser Ala Ser Lys 
        35                  40                  45              


Lys Tyr Asn Ile Ser Trp Glu Leu Gly Asn Glu Pro Asn Asn Tyr Arg 
    50                  55                  60                  


Thr Met His Gly Arg Ala Val Asn Gly Ser Gln Leu Gly Lys Asp Tyr 
65                  70                  75                  80  


Ile Gln Leu Lys Ser Leu Leu Gln Pro Ile Arg Ile Tyr Ser Arg Ala 
                85                  90                  95      


Ser Leu Tyr Gly Pro Asn Ile Gly Arg Pro Arg Lys Asn Val Ile Ala 
            100                 105                 110         


Leu Leu Asp Gly Phe Met Lys Val Ala Gly Ser Thr Val Asp Ala Val 
        115                 120                 125             


Thr Trp Gln His Cys Tyr Ile Asp Gly Arg Val Val Lys Val Met Asp 
    130                 135                 140                 


Phe Leu Lys Thr Arg Leu Leu Asp Thr Leu Ser Asp Gln Ile Arg Lys 
145                 150                 155                 160 


Ile Gln Lys Val Val Asn Thr Tyr Thr Pro Gly Lys Lys Ile Trp Leu 
                165                 170                 175     


Glu Gly Val Val Thr Thr Ser Ala Gly Gly Thr Asn Asn Leu Ser Asp 
            180                 185                 190         


Ser Tyr Ala Ala Gly Phe Leu Trp Leu Asn Thr Leu Gly Met Leu Ala 
        195                 200                 205             


Asn Gln Gly Ile Asp Val Val Ile Arg His Ser Phe Phe Asp His Gly 
    210                 215                 220                 


Tyr Asn His Leu Val Asp Gln Asn Phe Asn Pro Leu Pro Asp Tyr Trp 
225                 230                 235                 240 


Leu Ser Leu Leu Tyr Lys Arg Leu Ile Gly Pro Lys Val Leu Ala Val 
                245                 250                 255     


His Val Ala Gly Leu Gln Arg Lys Pro Arg Pro Gly Arg Val Ile Arg 
            260                 265                 270         


Asp Lys Leu Arg Ile Tyr Ala His Cys Thr Asn His His Asn His Asn 
        275                 280                 285             


Tyr Val Arg Gly Ser Ile Thr Leu Phe Ile Ile Asn Leu His Arg Ser 
    290                 295                 300                 


Arg Lys Lys Ile Lys Leu Ala Gly Thr Leu Arg Asp Lys Leu Val His 
305                 310                 315                 320 


Gln Tyr Leu Leu Gln Pro Tyr Gly Gln Glu Gly Leu Lys Ser Lys Ser 
                325                 330                 335     


Val Gln Leu Asn Gly Gln Pro Leu Val Met Val Asp Asp Gly Thr Leu 
            340                 345                 350         


Pro Glu Leu Lys Pro Arg Pro Leu Arg Ala Gly Arg Thr Leu Val Ile 
        355                 360                 365             


Pro Pro Val Thr Met Gly Phe Tyr Val Val Lys Asn Val Asn Ala Leu 
    370                 375                 380                 


Ala Cys Arg Tyr Arg 
385                 


<210>  6556
<211>  149
<212>  PRT
<213>  Homo Sapiens

<400>  6556

Met Arg Val Leu Cys Ala Phe Pro Glu Ala Met Pro Ser Ser Asn Ser 
1               5                   10                  15      


Arg Pro Pro Ala Cys Leu Ala Pro Gly Ala Leu Tyr Leu Ala Leu Leu 
            20                  25                  30          


Leu His Leu Ser Leu Ser Ser Gln Ala Gly Asp Arg Arg Pro Leu Pro 
        35                  40                  45              


Val Asp Arg Ala Ala Gly Leu Lys Glu Lys Thr Leu Ile Leu Leu Asp 
    50                  55                  60                  


Val Ser Thr Lys Asn Pro Val Arg Thr Val Asn Glu Asn Phe Leu Ser 
65                  70                  75                  80  


Leu Gln Leu Asp Pro Ser Ile Ile His Asp Gly Trp Leu Asp Phe Leu 
                85                  90                  95      


Ser Ser Lys Arg Leu Val Thr Leu Ala Arg Gly Leu Ser Pro Ala Phe 
            100                 105                 110         


Leu Arg Phe Gly Gly Lys Arg Thr Asp Phe Leu Gln Phe Gln Asn Leu 
        115                 120                 125             


Arg Asn Pro Ala Lys Ser Arg Gly Gly Pro Gly Pro Asp Tyr Tyr Leu 
    130                 135                 140                 


Lys Asn Tyr Glu Asp 
145                 


<210>  6557
<211>  592
<212>  PRT
<213>  Homo Sapiens

<400>  6557

Met Arg Val Leu Cys Ala Phe Pro Glu Ala Met Pro Ser Ser Asn Ser 
1               5                   10                  15      


Arg Pro Pro Ala Cys Leu Ala Pro Gly Ala Leu Tyr Leu Ala Leu Leu 
            20                  25                  30          


Leu His Leu Ser Leu Ser Ser Gln Ala Gly Asp Arg Arg Pro Leu Pro 
        35                  40                  45              


Val Asp Arg Ala Ala Gly Leu Lys Glu Lys Thr Leu Ile Leu Leu Asp 
    50                  55                  60                  


Val Ser Thr Lys Asn Pro Val Arg Thr Val Asn Glu Asn Phe Leu Ser 
65                  70                  75                  80  


Leu Gln Leu Asp Pro Ser Ile Ile His Asp Gly Trp Leu Asp Phe Leu 
                85                  90                  95      


Ser Ser Lys Arg Leu Val Thr Leu Ala Arg Gly Leu Ser Pro Ala Phe 
            100                 105                 110         


Leu Arg Phe Gly Gly Lys Arg Thr Asp Phe Leu Gln Phe Gln Asn Leu 
        115                 120                 125             


Arg Asn Pro Ala Lys Ser Arg Gly Gly Pro Gly Pro Asp Tyr Tyr Leu 
    130                 135                 140                 


Lys Asn Tyr Glu Asp Asp Ile Val Arg Ser Asp Val Ala Leu Asp Lys 
145                 150                 155                 160 


Gln Lys Gly Cys Lys Ile Ala Gln His Pro Asp Val Met Leu Glu Leu 
                165                 170                 175     


Gln Arg Glu Lys Ala Ala Gln Met His Leu Val Leu Leu Lys Glu Gln 
            180                 185                 190         


Phe Ser Asn Thr Tyr Ser Asn Leu Ile Leu Thr Ala Arg Ser Leu Asp 
        195                 200                 205             


Lys Leu Tyr Asn Phe Ala Asp Cys Ser Gly Leu His Leu Ile Phe Ala 
    210                 215                 220                 


Leu Asn Ala Leu Arg Arg Asn Pro Asn Asn Ser Trp Asn Ser Ser Ser 
225                 230                 235                 240 


Ala Leu Ser Leu Leu Lys Tyr Ser Ala Ser Lys Lys Tyr Asn Ile Ser 
                245                 250                 255     


Trp Glu Leu Gly Asn Glu Pro Asn Asn Tyr Arg Thr Met His Gly Arg 
            260                 265                 270         


Ala Val Asn Gly Ser Gln Leu Gly Lys Asp Tyr Ile Gln Leu Lys Ser 
        275                 280                 285             


Leu Leu Gln Pro Ile Arg Ile Tyr Ser Arg Ala Ser Leu Tyr Gly Pro 
    290                 295                 300                 


Asn Ile Gly Arg Pro Arg Lys Asn Val Ile Ala Leu Leu Asp Gly Phe 
305                 310                 315                 320 


Met Lys Val Ala Gly Ser Thr Val Asp Ala Val Thr Trp Gln His Cys 
                325                 330                 335     


Tyr Ile Asp Gly Arg Val Val Lys Val Met Asp Phe Leu Lys Thr Arg 
            340                 345                 350         


Leu Leu Asp Thr Leu Ser Asp Gln Ile Arg Lys Ile Gln Lys Val Val 
        355                 360                 365             


Asn Thr Tyr Thr Pro Gly Lys Lys Ile Trp Leu Glu Gly Val Val Thr 
    370                 375                 380                 


Thr Ser Ala Gly Gly Thr Asn Asn Leu Ser Asp Ser Tyr Ala Ala Gly 
385                 390                 395                 400 


Phe Leu Trp Leu Asn Thr Leu Gly Met Leu Ala Asn Gln Gly Ile Asp 
                405                 410                 415     


Val Val Ile Arg His Ser Phe Phe Asp His Gly Tyr Asn His Leu Val 
            420                 425                 430         


Asp Gln Asn Phe Asn Pro Leu Pro Asp Tyr Trp Leu Ser Leu Leu Tyr 
        435                 440                 445             


Lys Arg Leu Ile Gly Pro Lys Val Leu Ala Val His Val Ala Gly Leu 
    450                 455                 460                 


Gln Arg Lys Pro Arg Pro Gly Arg Val Ile Arg Asp Lys Leu Arg Ile 
465                 470                 475                 480 


Tyr Ala His Cys Thr Asn His His Asn His Asn Tyr Val Arg Gly Ser 
                485                 490                 495     


Ile Thr Leu Phe Ile Ile Asn Leu His Arg Ser Arg Lys Lys Ile Lys 
            500                 505                 510         


Leu Ala Gly Thr Leu Arg Asp Lys Leu Val His Gln Tyr Leu Leu Gln 
        515                 520                 525             


Pro Tyr Gly Gln Glu Gly Leu Lys Ser Lys Ser Val Gln Leu Asn Gly 
    530                 535                 540                 


Gln Pro Leu Val Met Val Asp Asp Gly Thr Leu Pro Glu Leu Lys Pro 
545                 550                 555                 560 


Arg Pro Leu Arg Ala Gly Arg Thr Leu Val Ile Pro Pro Val Thr Met 
                565                 570                 575     


Gly Phe Tyr Val Val Lys Asn Val Asn Ala Leu Ala Cys Arg Tyr Arg 
            580                 585                 590         


<210>  6558
<211>  548
<212>  PRT
<213>  Homo Sapiens

<400>  6558

Met Arg Val Leu Cys Ala Phe Pro Glu Ala Met Pro Ser Ser Asn Ser 
1               5                   10                  15      


Arg Pro Pro Ala Cys Leu Ala Pro Gly Ala Leu Tyr Leu Ala Leu Leu 
            20                  25                  30          


Leu His Leu Ser Leu Ser Ser Gln Ala Gly Asp Arg Arg Pro Leu Pro 
        35                  40                  45              


Val Asp Arg Ala Ala Gly Leu Lys Glu Lys Thr Leu Ile Leu Leu Asp 
    50                  55                  60                  


Val Ser Thr Lys Asn Pro Val Arg Thr Val Asn Glu Asn Phe Leu Ser 
65                  70                  75                  80  


Leu Gln Leu Asp Pro Ser Ile Ile His Asp Gly Trp Leu Asp Phe Leu 
                85                  90                  95      


Ser Ser Lys Arg Leu Val Thr Leu Ala Arg Gly Leu Ser Pro Ala Phe 
            100                 105                 110         


Leu Arg Phe Gly Gly Lys Arg Thr Asp Phe Leu Gln Phe Gln Asn Leu 
        115                 120                 125             


Arg Asn Pro Ala Lys Ser Arg Gly Gly Pro Gly Pro Asp Tyr Tyr Leu 
    130                 135                 140                 


Lys Asn Tyr Glu Asp Asp Ile Val Arg Ser Asp Val Ala Leu Asp Lys 
145                 150                 155                 160 


Gln Lys Gly Cys Lys Ile Ala Gln His Pro Asp Val Met Leu Glu Leu 
                165                 170                 175     


Gln Arg Glu Lys Ala Ala Gln Met His Leu Val Leu Leu Lys Glu Gln 
            180                 185                 190         


Phe Ser Asn Thr Tyr Ser Asn Leu Ile Leu Thr Ala Arg Ser Leu Asp 
        195                 200                 205             


Lys Leu Tyr Asn Phe Ala Asp Cys Ser Gly Leu His Leu Ile Phe Ala 
    210                 215                 220                 


Leu Asn Ala Leu Arg Arg Asn Pro Asn Asn Ser Trp Asn Ser Ser Ser 
225                 230                 235                 240 


Ala Leu Ser Leu Leu Lys Tyr Ser Ala Ser Lys Lys Tyr Asn Ile Ser 
                245                 250                 255     


Trp Glu Leu Gly Asn Glu Pro Asn Asn Tyr Arg Thr Met His Gly Arg 
            260                 265                 270         


Ala Val Asn Gly Ser Gln Leu Gly Lys Asp Tyr Ile Gln Leu Lys Ser 
        275                 280                 285             


Leu Leu Gln Pro Ile Arg Ile Tyr Ser Arg Ala Ser Leu Tyr Gly Pro 
    290                 295                 300                 


Asn Ile Gly Arg Pro Arg Lys Asn Val Ile Ala Leu Leu Asp Gly Phe 
305                 310                 315                 320 


Met Lys Val Ala Gly Ser Thr Val Asp Ala Val Thr Trp Gln His Cys 
                325                 330                 335     


Tyr Ile Asp Gly Arg Val Val Lys Val Met Asp Phe Leu Lys Thr Arg 
            340                 345                 350         


Leu Leu Asp Thr Leu Ser Asp Gln Ile Arg Lys Ile Gln Lys Val Val 
        355                 360                 365             


Asn Thr Tyr Thr Pro Gly Lys Lys Ile Trp Leu Glu Gly Val Val Thr 
    370                 375                 380                 


Thr Ser Ala Gly Gly Thr Asn Asn Leu Ser Asp Ser Tyr Ala Ala Gly 
385                 390                 395                 400 


Phe Leu Trp Leu Asn Thr Leu Gly Met Leu Ala Asn Gln Gly Ile Asp 
                405                 410                 415     


Val Val Ile Arg His Ser Phe Phe Asp His Gly Tyr Asn His Leu Val 
            420                 425                 430         


Asp Gln Asn Phe Asn Pro Leu Pro Asp Tyr Trp Leu Ser Leu Leu Tyr 
        435                 440                 445             


Lys Arg Leu Ile Gly Pro Lys Val Leu Ala Val His Val Ala Gly Leu 
    450                 455                 460                 


Gln Arg Lys Pro Arg Pro Gly Arg Val Ile Arg Asp Lys Leu Arg Ile 
465                 470                 475                 480 


Tyr Ala His Cys Thr Asn His His Asn His Asn Tyr Val Arg Gly Ser 
                485                 490                 495     


Ile Thr Leu Phe Ile Ile Asn Leu His Arg Ser Arg Lys Lys Ile Lys 
            500                 505                 510         


Leu Ala Gly Thr Leu Arg Asp Lys Leu Val His Gln Tyr Leu Leu Gln 
        515                 520                 525             


Pro Tyr Gly Gln Glu Gly Leu Lys Ser Lys Thr Gln Arg Cys Gln Tyr 
    530                 535                 540                 


Cys Gly Ile Ile 
545             


<210>  6559
<211>  534
<212>  PRT
<213>  Homo Sapiens

<400>  6559

Met Arg Val Leu Cys Ala Phe Pro Glu Ala Met Pro Ser Ser Asn Ser 
1               5                   10                  15      


Arg Pro Pro Ala Cys Leu Ala Pro Gly Ala Leu Tyr Leu Ala Leu Leu 
            20                  25                  30          


Leu His Leu Ser Leu Ser Ser Gln Ala Gly Asp Arg Arg Pro Leu Pro 
        35                  40                  45              


Val Asp Arg Ala Ala Gly Leu Lys Glu Lys Thr Leu Ile Leu Leu Asp 
    50                  55                  60                  


Val Ser Thr Lys Asn Pro Val Arg Thr Val Asn Glu Asn Phe Leu Ser 
65                  70                  75                  80  


Leu Gln Leu Asp Pro Ser Ile Ile His Asp Gly Trp Leu Asp Phe Leu 
                85                  90                  95      


Ser Ser Lys Arg Leu Val Thr Leu Ala Arg Gly Leu Ser Pro Ala Phe 
            100                 105                 110         


Leu Arg Phe Gly Gly Lys Arg Thr Asp Phe Leu Gln Phe Gln Asn Leu 
        115                 120                 125             


Arg Asn Pro Ala Lys Ser Arg Gly Gly Pro Gly Pro Asp Tyr Tyr Leu 
    130                 135                 140                 


Lys Asn Tyr Glu Asp Asp Ile Val Arg Ser Asp Val Ala Leu Asp Lys 
145                 150                 155                 160 


Gln Lys Gly Cys Lys Ile Ala Gln His Pro Asp Val Met Leu Glu Leu 
                165                 170                 175     


Gln Arg Glu Lys Ala Ala Gln Met His Leu Val Leu Leu Lys Glu Gln 
            180                 185                 190         


Phe Ser Asn Thr Tyr Ser Asn Leu Ile Leu Thr Glu Pro Asn Asn Tyr 
        195                 200                 205             


Arg Thr Met His Gly Arg Ala Val Asn Gly Ser Gln Leu Gly Lys Asp 
    210                 215                 220                 


Tyr Ile Gln Leu Lys Ser Leu Leu Gln Pro Ile Arg Ile Tyr Ser Arg 
225                 230                 235                 240 


Ala Ser Leu Tyr Gly Pro Asn Ile Gly Arg Pro Arg Lys Asn Val Ile 
                245                 250                 255     


Ala Leu Leu Asp Gly Phe Met Lys Val Ala Gly Ser Thr Val Asp Ala 
            260                 265                 270         


Val Thr Trp Gln His Cys Tyr Ile Asp Gly Arg Val Val Lys Val Met 
        275                 280                 285             


Asp Phe Leu Lys Thr Arg Leu Leu Asp Thr Leu Ser Asp Gln Ile Arg 
    290                 295                 300                 


Lys Ile Gln Lys Val Val Asn Thr Tyr Thr Pro Gly Lys Lys Ile Trp 
305                 310                 315                 320 


Leu Glu Gly Val Val Thr Thr Ser Ala Gly Gly Thr Asn Asn Leu Ser 
                325                 330                 335     


Asp Ser Tyr Ala Ala Gly Phe Leu Trp Leu Asn Thr Leu Gly Met Leu 
            340                 345                 350         


Ala Asn Gln Gly Ile Asp Val Val Ile Arg His Ser Phe Phe Asp His 
        355                 360                 365             


Gly Tyr Asn His Leu Val Asp Gln Asn Phe Asn Pro Leu Pro Asp Tyr 
    370                 375                 380                 


Trp Leu Ser Leu Leu Tyr Lys Arg Leu Ile Gly Pro Lys Val Leu Ala 
385                 390                 395                 400 


Val His Val Ala Gly Leu Gln Arg Lys Pro Arg Pro Gly Arg Val Ile 
                405                 410                 415     


Arg Asp Lys Leu Arg Ile Tyr Ala His Cys Thr Asn His His Asn His 
            420                 425                 430         


Asn Tyr Val Arg Gly Ser Ile Thr Leu Phe Ile Ile Asn Leu His Arg 
        435                 440                 445             


Ser Arg Lys Lys Ile Lys Leu Ala Gly Thr Leu Arg Asp Lys Leu Val 
    450                 455                 460                 


His Gln Tyr Leu Leu Gln Pro Tyr Gly Gln Glu Gly Leu Lys Ser Lys 
465                 470                 475                 480 


Ser Val Gln Leu Asn Gly Gln Pro Leu Val Met Val Asp Asp Gly Thr 
                485                 490                 495     


Leu Pro Glu Leu Lys Pro Arg Pro Leu Arg Ala Gly Arg Thr Leu Val 
            500                 505                 510         


Ile Pro Pro Val Thr Met Gly Phe Tyr Val Val Lys Asn Val Asn Ala 
        515                 520                 525             


Leu Ala Cys Arg Tyr Arg 
    530                 


<210>  6560
<211>  480
<212>  PRT
<213>  Homo Sapiens

<400>  6560

Met Arg Val Leu Cys Ala Phe Pro Glu Ala Met Pro Ser Ser Asn Ser 
1               5                   10                  15      


Arg Pro Pro Ala Cys Leu Ala Pro Gly Ala Leu Tyr Leu Ala Leu Leu 
            20                  25                  30          


Leu His Leu Ser Leu Ser Ser Gln Ala Gly Asp Arg Arg Pro Leu Pro 
        35                  40                  45              


Val Asp Arg Ala Ala Gly Leu Lys Glu Lys Thr Leu Ile Leu Leu Asp 
    50                  55                  60                  


Val Ser Thr Lys Asn Pro Val Arg Thr Val Asn Glu Asn Phe Leu Ser 
65                  70                  75                  80  


Leu Gln Leu Asp Pro Ser Ile Ile His Asp Gly Trp Leu Asp Phe Leu 
                85                  90                  95      


Ser Ser Lys Arg Leu Val Thr Leu Ala Arg Gly Leu Ser Pro Ala Phe 
            100                 105                 110         


Leu Arg Phe Gly Gly Lys Arg Thr Asp Phe Leu Gln Phe Gln Asn Leu 
        115                 120                 125             


Arg Asn Pro Ala Lys Ser Arg Gly Gly Pro Gly Pro Asp Tyr Tyr Leu 
    130                 135                 140                 


Lys Asn Tyr Glu Asp Glu Pro Asn Asn Tyr Arg Thr Met His Gly Arg 
145                 150                 155                 160 


Ala Val Asn Gly Ser Gln Leu Gly Lys Asp Tyr Ile Gln Leu Lys Ser 
                165                 170                 175     


Leu Leu Gln Pro Ile Arg Ile Tyr Ser Arg Ala Ser Leu Tyr Gly Pro 
            180                 185                 190         


Asn Ile Gly Arg Pro Arg Lys Asn Val Ile Ala Leu Leu Asp Gly Phe 
        195                 200                 205             


Met Lys Val Ala Gly Ser Thr Val Asp Ala Val Thr Trp Gln His Cys 
    210                 215                 220                 


Tyr Ile Asp Gly Arg Val Val Lys Val Met Asp Phe Leu Lys Thr Arg 
225                 230                 235                 240 


Leu Leu Asp Thr Leu Ser Asp Gln Ile Arg Lys Ile Gln Lys Val Val 
                245                 250                 255     


Asn Thr Tyr Thr Pro Gly Lys Lys Ile Trp Leu Glu Gly Val Val Thr 
            260                 265                 270         


Thr Ser Ala Gly Gly Thr Asn Asn Leu Ser Asp Ser Tyr Ala Ala Gly 
        275                 280                 285             


Phe Leu Trp Leu Asn Thr Leu Gly Met Leu Ala Asn Gln Gly Ile Asp 
    290                 295                 300                 


Val Val Ile Arg His Ser Phe Phe Asp His Gly Tyr Asn His Leu Val 
305                 310                 315                 320 


Asp Gln Asn Phe Asn Pro Leu Pro Asp Tyr Trp Leu Ser Leu Leu Tyr 
                325                 330                 335     


Lys Arg Leu Ile Gly Pro Lys Val Leu Ala Val His Val Ala Gly Leu 
            340                 345                 350         


Gln Arg Lys Pro Arg Pro Gly Arg Val Ile Arg Asp Lys Leu Arg Ile 
        355                 360                 365             


Tyr Ala His Cys Thr Asn His His Asn His Asn Tyr Val Arg Gly Ser 
    370                 375                 380                 


Ile Thr Leu Phe Ile Ile Asn Leu His Arg Ser Arg Lys Lys Ile Lys 
385                 390                 395                 400 


Leu Ala Gly Thr Leu Arg Asp Lys Leu Val His Gln Tyr Leu Leu Gln 
                405                 410                 415     


Pro Tyr Gly Gln Glu Gly Leu Lys Ser Lys Ser Val Gln Leu Asn Gly 
            420                 425                 430         


Gln Pro Leu Val Met Val Asp Asp Gly Thr Leu Pro Glu Leu Lys Pro 
        435                 440                 445             


Arg Pro Leu Arg Ala Gly Arg Thr Leu Val Ile Pro Pro Val Thr Met 
    450                 455                 460                 


Gly Phe Tyr Val Val Lys Asn Val Asn Ala Leu Ala Cys Arg Tyr Arg 
465                 470                 475                 480 


<210>  6561
<211>  254
<212>  PRT
<213>  Homo Sapiens

<400>  6561

Met Ala Arg Val Leu Gly Ala Pro Val Ala Leu Gly Leu Trp Ser Leu 
1               5                   10                  15      


Cys Trp Ser Leu Ala Ile Ala Thr Pro Leu Pro Pro Thr Ser Ala His 
            20                  25                  30          


Gly Asn Val Ala Glu Gly Glu Thr Lys Pro Asp Pro Asp Val Thr Glu 
        35                  40                  45              


Arg Cys Ser Asp Gly Trp Ser Phe Asp Ala Thr Thr Leu Asp Asp Asn 
    50                  55                  60                  


Gly Thr Met Leu Phe Phe Lys Gly Glu Phe Val Trp Lys Ser His Lys 
65                  70                  75                  80  


Trp Asp Arg Glu Leu Ile Ser Glu Arg Trp Lys Asn Phe Pro Ser Pro 
                85                  90                  95      


Val Asp Ala Ala Phe Arg Gln Gly His Asn Ser Val Phe Leu Ile Lys 
            100                 105                 110         


Gly Asp Lys Val Trp Val Tyr Pro Pro Glu Lys Lys Glu Lys Gly Tyr 
        115                 120                 125             


Pro Lys Leu Leu Gln Asp Glu Phe Pro Gly Ile Pro Ser Pro Leu Asp 
    130                 135                 140                 


Ala Ala Val Glu Cys His Arg Gly Glu Cys Gln Ala Glu Gly Val Leu 
145                 150                 155                 160 


Phe Phe Gln Gly Asp Arg Glu Trp Phe Trp Asp Leu Ala Thr Gly Thr 
                165                 170                 175     


Met Lys Glu Arg Ser Trp Pro Ala Val Gly Asn Cys Ser Ser Ala Leu 
            180                 185                 190         


Arg Trp Leu Gly Arg Tyr Tyr Cys Phe Gln Gly Asn Gln Phe Leu Arg 
        195                 200                 205             


Phe Asp Pro Val Arg Gly Glu Val Pro Pro Arg Tyr Pro Arg Asp Val 
    210                 215                 220                 


Arg Asp Tyr Phe Met Pro Cys Pro Gly Arg Gly His Gly His Arg Asn 
225                 230                 235                 240 


Gly Thr Gly His Gly Asn Ser Ile Cys Ala Val Ala His Ile 
                245                 250                 


<210>  6562
<211>  462
<212>  PRT
<213>  Homo Sapiens

<400>  6562

Met Ala Arg Val Leu Gly Ala Pro Val Ala Leu Gly Leu Trp Ser Leu 
1               5                   10                  15      


Cys Trp Ser Leu Ala Ile Ala Thr Pro Leu Pro Pro Thr Ser Ala His 
            20                  25                  30          


Gly Asn Val Ala Glu Gly Glu Thr Lys Pro Asp Pro Asp Val Thr Glu 
        35                  40                  45              


Arg Cys Ser Asp Gly Trp Ser Phe Asp Ala Thr Thr Leu Asp Asp Asn 
    50                  55                  60                  


Gly Thr Met Leu Phe Phe Lys Gly Glu Phe Val Trp Lys Ser His Lys 
65                  70                  75                  80  


Trp Asp Arg Glu Leu Ile Ser Glu Arg Trp Lys Asn Phe Pro Ser Pro 
                85                  90                  95      


Val Asp Ala Ala Phe Arg Gln Gly His Asn Ser Val Phe Leu Ile Lys 
            100                 105                 110         


Gly Asp Lys Val Trp Val Tyr Pro Pro Glu Lys Lys Glu Lys Gly Tyr 
        115                 120                 125             


Pro Lys Leu Leu Gln Asp Glu Phe Pro Gly Ile Pro Ser Pro Leu Asp 
    130                 135                 140                 


Ala Ala Val Glu Cys His Arg Gly Glu Cys Gln Ala Glu Gly Val Leu 
145                 150                 155                 160 


Phe Phe Gln Gly Asp Arg Glu Trp Phe Trp Asp Leu Ala Thr Gly Thr 
                165                 170                 175     


Met Lys Glu Arg Ser Trp Pro Ala Val Gly Asn Cys Ser Ser Ala Leu 
            180                 185                 190         


Arg Trp Leu Gly Arg Tyr Tyr Cys Phe Gln Gly Asn Gln Phe Leu Arg 
        195                 200                 205             


Phe Asp Pro Val Arg Gly Glu Val Pro Pro Arg Tyr Pro Arg Asp Val 
    210                 215                 220                 


Arg Asp Tyr Phe Met Pro Cys Pro Gly Arg Gly His Gly His Arg Asn 
225                 230                 235                 240 


Gly Thr Gly His Gly Asn Ser Thr His His Gly Pro Glu Tyr Met Arg 
                245                 250                 255     


Cys Ser Pro His Leu Val Leu Ser Ala Leu Thr Ser Asp Asn His Gly 
            260                 265                 270         


Ala Thr Tyr Ala Phe Ser Gly Thr His Tyr Trp Arg Leu Asp Thr Ser 
        275                 280                 285             


Arg Asp Gly Trp His Ser Trp Pro Ile Ala His Gln Trp Pro Gln Gly 
    290                 295                 300                 


Pro Ser Ala Val Asp Ala Ala Phe Ser Trp Glu Glu Lys Leu Tyr Leu 
305                 310                 315                 320 


Val Gln Gly Thr Gln Val Tyr Val Phe Leu Thr Lys Gly Gly Tyr Thr 
                325                 330                 335     


Leu Val Ser Gly Tyr Pro Lys Arg Leu Glu Lys Glu Val Gly Thr Pro 
            340                 345                 350         


His Gly Ile Ile Leu Asp Ser Val Asp Ala Ala Phe Ile Cys Pro Gly 
        355                 360                 365             


Ser Ser Arg Leu His Ile Met Ala Gly Arg Arg Leu Trp Trp Leu Asp 
    370                 375                 380                 


Leu Lys Ser Gly Ala Gln Ala Thr Trp Thr Glu Leu Pro Trp Pro His 
385                 390                 395                 400 


Glu Lys Val Asp Gly Ala Leu Cys Met Glu Lys Ser Leu Gly Pro Asn 
                405                 410                 415     


Ser Cys Ser Ala Asn Gly Pro Gly Leu Tyr Leu Ile His Gly Pro Asn 
            420                 425                 430         


Leu Tyr Cys Tyr Ser Asp Val Glu Lys Leu Asn Ala Ala Lys Ala Leu 
        435                 440                 445             


Pro Gln Pro Gln Asn Val Thr Ser Leu Leu Gly Cys Thr His 
    450                 455                 460         


<210>  6563
<211>  699
<212>  PRT
<213>  Homo Sapiens

<400>  6563

Met Gly His His Arg Pro Trp Leu His Ala Ser Val Leu Trp Ala Gly 
1               5                   10                  15      


Val Ala Ser Leu Leu Leu Pro Pro Ala Met Thr Gln Gln Leu Arg Gly 
            20                  25                  30          


Asp Gly Leu Gly Phe Arg Asn Arg Asn Asn Ser Thr Gly Val Ala Gly 
        35                  40                  45              


Leu Ser Glu Glu Ala Ser Ala Glu Leu Arg His His Leu His Ser Pro 
    50                  55                  60                  


Arg Asp His Pro Asp Glu Asn Lys Asp Val Ser Thr Glu Asn Gly His 
65                  70                  75                  80  


His Phe Trp Ser His Pro Asp Arg Glu Lys Glu Asp Glu Asp Val Ser 
                85                  90                  95      


Lys Glu Tyr Gly His Leu Leu Pro Gly His Arg Ser Gln Asp His Lys 
            100                 105                 110         


Val Gly Asp Glu Gly Val Ser Gly Glu Glu Val Phe Ala Glu His Gly 
        115                 120                 125             


Gly Gln Ala Arg Gly His Arg Gly His Gly Ser Glu Asp Thr Glu Asp 
    130                 135                 140                 


Ser Ala Glu His Arg His His Leu Pro Ser His Arg Ser His Ser His 
145                 150                 155                 160 


Gln Asp Glu Asp Glu Asp Glu Val Val Ser Ser Glu His His His His 
                165                 170                 175     


Ile Leu Arg His Gly His Arg Gly His Asp Gly Glu Asp Asp Glu Gly 
            180                 185                 190         


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Ala Ser Thr Glu 
        195                 200                 205             


Tyr Gly His Gln Ala His Arg His Arg Gly His Gly Ser Glu Glu Asp 
    210                 215                 220                 


Glu Asp Val Ser Asp Gly His His His His Gly Pro Ser His Arg His 
225                 230                 235                 240 


Gln Gly His Glu Glu Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp 
                245                 250                 255     


Asp Asp Asp Asp Asp Val Ser Ile Glu Tyr Arg His Gln Ala His Arg 
            260                 265                 270         


His Gln Gly His Gly Ile Glu Glu Asp Glu Asp Val Ser Asp Gly His 
        275                 280                 285             


His His Arg Asp Pro Ser His Arg His Arg Ser His Glu Glu Asp Asp 
    290                 295                 300                 


Asn Asp Asp Asp Asp Val Ser Thr Glu Tyr Gly His Gln Ala His Arg 
305                 310                 315                 320 


His Gln Asp His Arg Lys Glu Glu Val Glu Ala Val Ser Gly Glu His 
                325                 330                 335     


His His His Val Pro Asp His Arg His Gln Gly His Arg Asp Glu Glu 
            340                 345                 350         


Glu Asp Glu Asp Val Ser Thr Glu Arg Trp His Gln Gly Pro Gln His 
        355                 360                 365             


Val His His Gly Leu Val Asp Glu Glu Glu Glu Glu Glu Glu Ile Thr 
    370                 375                 380                 


Val Gln Phe Gly His Tyr Val Ala Ser His Gln Pro Arg Gly His Lys 
385                 390                 395                 400 


Ser Asp Glu Glu Asp Phe Gln Asp Glu Tyr Lys Thr Glu Val Pro His 
                405                 410                 415     


His His His His Arg Val Pro Arg Glu Glu Asp Glu Glu Val Ser Ala 
            420                 425                 430         


Glu Leu Gly His Gln Ala Pro Ser His Arg Gln Ser His Gln Asp Glu 
        435                 440                 445             


Glu Thr Gly His Gly Gln Arg Gly Ser Ile Lys Glu Met Ser His His 
    450                 455                 460                 


Pro Pro Gly His Thr Val Val Lys Asp Arg Ser His Leu Arg Lys Asp 
465                 470                 475                 480 


Asp Ser Glu Glu Glu Lys Glu Lys Glu Glu Asp Pro Gly Ser His Glu 
                485                 490                 495     


Glu Asp Asp Glu Ser Ser Glu Gln Gly Glu Lys Gly Thr His His Gly 
            500                 505                 510         


Ser Arg Asp Gln Glu Asp Glu Glu Asp Glu Glu Glu Gly His Gly Leu 
        515                 520                 525             


Ser Leu Asn Gln Glu Glu Glu Glu Glu Glu Asp Lys Glu Glu Glu Glu 
    530                 535                 540                 


Glu Glu Glu Asp Glu Glu Arg Arg Glu Glu Arg Ala Glu Val Gly Ala 
545                 550                 555                 560 


Pro Leu Ser Pro Asp His Ser Glu Glu Glu Glu Glu Glu Glu Glu Gly 
                565                 570                 575     


Leu Glu Glu Asp Glu Pro Arg Phe Thr Ile Ile Pro Asn Pro Leu Asp 
            580                 585                 590         


Arg Arg Glu Glu Ala Gly Gly Ala Ser Ser Glu Glu Glu Ser Gly Glu 
        595                 600                 605             


Asp Thr Gly Pro Gln Asp Ala Gln Glu Tyr Gly Asn Tyr Gln Pro Gly 
    610                 615                 620                 


Ser Leu Cys Gly Tyr Cys Ser Phe Cys Asn Arg Cys Thr Glu Cys Glu 
625                 630                 635                 640 


Ser Cys His Cys Asp Glu Glu Asn Met Gly Glu His Cys Asp Gln Cys 
                645                 650                 655     


Gln His Cys Gln Phe Cys Tyr Leu Cys Pro Leu Val Cys Glu Thr Val 
            660                 665                 670         


Cys Ala Pro Gly Ser Tyr Val Asp Tyr Phe Ser Ser Ser Leu Tyr Gln 
        675                 680                 685             


Ala Leu Ala Asp Met Leu Glu Thr Pro Glu Pro 
    690                 695                 


<210>  6564
<211>  676
<212>  PRT
<213>  Homo Sapiens

<400>  6564

Met Gly His His Arg Pro Trp Leu His Ala Ser Val Leu Trp Ala Gly 
1               5                   10                  15      


Val Ala Ser Leu Leu Leu Pro Pro Ala Met Thr Gln Gln Leu Arg Gly 
            20                  25                  30          


Asp Gly Leu Gly Phe Arg Asn Arg Asn Asn Ser Thr Gly Val Ala Gly 
        35                  40                  45              


Leu Ser Glu Glu Ala Ser Ala Glu Leu Arg His His Leu His Ser Pro 
    50                  55                  60                  


Arg Asp His Pro Asp Glu Asn Lys Asp Val Ser Thr Glu Asn Gly His 
65                  70                  75                  80  


His Phe Trp Ser His Pro Asp Arg Glu Lys Glu Asp Glu Asp Val Ser 
                85                  90                  95      


Lys Glu Tyr Gly His Leu Leu Pro Gly His Arg Ser Gln Asp His Lys 
            100                 105                 110         


Val Gly Asp Glu Gly Val Ser Gly Glu Glu Val Phe Ala Glu His Gly 
        115                 120                 125             


Gly Gln Ala Arg Gly His Arg Gly His Gly Ser Glu Asp Thr Glu Asp 
    130                 135                 140                 


Ser Ala Glu His Arg His His Leu Pro Ser His Arg Ser His Ser His 
145                 150                 155                 160 


Gln Asp Glu Asp Glu Asp Glu Val Val Ser Ser Glu His His His His 
                165                 170                 175     


Ile Leu Arg His Gly His Arg Gly His Asp Gly Glu Asp Asp Glu Gly 
            180                 185                 190         


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Ala Ser Thr Glu 
        195                 200                 205             


Tyr Gly His Gln Ala His Arg His Arg Gly His Gly Ser Glu Glu Asp 
    210                 215                 220                 


Glu Asp Val Ser Asp Gly His His His His Gly Pro Ser His Arg His 
225                 230                 235                 240 


Gln Gly His Glu Glu Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp 
                245                 250                 255     


Asp Asp Asp Asp Asp Val Ser Ile Glu Tyr Arg His Gln Ala His Arg 
            260                 265                 270         


His Gln Gly His Gly Ile Glu Glu Asp Glu Asp Val Ser Asp Gly His 
        275                 280                 285             


His His Arg Asp Pro Ser His Arg His Arg Ser His Glu Glu Asp Asp 
    290                 295                 300                 


Asn Asp Asp Asp Asp Val Ser Thr Glu Tyr Gly His Gln Ala His Arg 
305                 310                 315                 320 


His Gln Asp His Arg Lys Glu Glu Val Glu Ala Val Ser Gly Glu His 
                325                 330                 335     


His His His Val Pro Asp His Arg His Gln Gly His Arg Asp Glu Glu 
            340                 345                 350         


Glu Asp Glu Asp Val Ser Thr Glu Arg Trp His Gln Gly Pro Gln His 
        355                 360                 365             


Val His His Gly Leu Val Asp Glu Glu Glu Glu Glu Glu Glu Ile Thr 
    370                 375                 380                 


Val Gln Phe Gly His Tyr Val Ala Ser His Gln Pro Arg Gly His Lys 
385                 390                 395                 400 


Ser Asp Glu Glu Asp Phe Gln Asp Glu Tyr Lys Thr Glu Val Pro His 
                405                 410                 415     


His His His His Arg Val Pro Arg Glu Glu Asp Glu Glu Val Ser Ala 
            420                 425                 430         


Glu Leu Gly His Gln Ala Pro Ser His Arg Gln Ser His Gln Asp Glu 
        435                 440                 445             


Glu Thr Gly His Gly Gln Arg Gly Ser Ile Lys Glu Met Ser His His 
    450                 455                 460                 


Pro Pro Gly His Thr Val Val Lys Asp Arg Ser His Leu Arg Lys Asp 
465                 470                 475                 480 


Asp Ser Glu Glu Glu Lys Glu Lys Glu Glu Asp Pro Gly Ser His Glu 
                485                 490                 495     


Glu Asp Asp Glu Ser Ser Glu Gln Gly Glu Lys Gly Thr His His Gly 
            500                 505                 510         


Ser Arg Asp Gln Glu Asp Glu Glu Asp Glu Glu Glu Gly His Gly Leu 
        515                 520                 525             


Ser Leu Asn Gln Glu Glu Glu Glu Glu Glu Asp Lys Glu Glu Glu Glu 
    530                 535                 540                 


Glu Glu Glu Asp Glu Glu Arg Arg Glu Glu Arg Ala Glu Val Gly Ala 
545                 550                 555                 560 


Pro Leu Ser Pro Asp His Ser Glu Glu Glu Glu Glu Glu Glu Glu Gly 
                565                 570                 575     


Leu Glu Glu Asp Glu Pro Arg Phe Thr Ile Ile Pro Asn Pro Leu Asp 
            580                 585                 590         


Arg Arg Glu Glu Ala Gly Gly Ala Ser Ser Glu Glu Glu Ser Gly Glu 
        595                 600                 605             


Asp Thr Gly Pro Gln Asp Ala Gln Glu Tyr Gly Asn Tyr Gln Pro Gly 
    610                 615                 620                 


Ser Leu Cys Gly Tyr Cys Ser Phe Cys Asn His Cys Gln Phe Cys Tyr 
625                 630                 635                 640 


Leu Cys Pro Leu Val Cys Glu Thr Val Cys Ala Pro Gly Ser Tyr Val 
                645                 650                 655     


Asp Tyr Phe Ser Ser Ser Leu Tyr Gln Ala Leu Ala Asp Met Leu Glu 
            660                 665                 670         


Thr Pro Glu Pro 
        675     


<210>  6565
<211>  96
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6565

Xaa Ser Glu Glu Glu Ser Gly Glu Asp Thr Gly Pro Gln Asp Ala Gln 
1               5                   10                  15      


Glu Tyr Gly Asn Tyr Gln Pro Gly Ser Leu Cys Gly Tyr Cys Ser Phe 
            20                  25                  30          


Cys Asn Arg Cys Thr Glu Cys Glu Ser Cys His Cys Asp Glu Glu Asn 
        35                  40                  45              


Met Gly Glu His Cys Asp Gln Cys Gln Gly Pro Gly Arg His Ala Gly 
    50                  55                  60                  


Asn Ala Gly Thr Leu Thr Gln Ser Leu Asp Cys Asp Ala Gly Val Pro 
65                  70                  75                  80  


Pro Pro Ala Phe Gln Pro Leu Ser Thr Ser Tyr Ile Tyr Phe Ser Glu 
                85                  90                  95      


<210>  6566
<211>  525
<212>  PRT
<213>  Homo Sapiens

<400>  6566

Met Lys Ala Leu Ile Ala Ala Leu Leu Leu Ile Thr Leu Gln Tyr Ser 
1               5                   10                  15      


Cys Ala Val Ser Pro Thr Asp Cys Ser Ala Val Glu Pro Glu Ala Glu 
            20                  25                  30          


Lys Ala Leu Asp Leu Ile Asn Lys Arg Arg Arg Asp Gly Tyr Leu Phe 
        35                  40                  45              


Gln Leu Leu Arg Ile Ala Asp Ala His Leu Asp Arg Val Glu Asn Thr 
    50                  55                  60                  


Thr Val Tyr Tyr Leu Val Leu Asp Val Gln Glu Ser Asp Cys Ser Val 
65                  70                  75                  80  


Leu Ser Arg Lys Tyr Trp Asn Asp Cys Glu Pro Pro Asp Ser Arg Arg 
                85                  90                  95      


Pro Ser Glu Ile Val Ile Gly Gln Cys Lys Val Ile Ala Thr Arg His 
            100                 105                 110         


Ser His Glu Ser Gln Asp Leu Arg Val Ile Asp Phe Asn Cys Thr Thr 
        115                 120                 125             


Ser Ser Val Ser Ser Ala Leu Ala Asn Thr Lys Asp Ser Pro Val Leu 
    130                 135                 140                 


Ile Asp Phe Phe Glu Asp Thr Glu Arg Tyr Arg Lys Gln Ala Asn Lys 
145                 150                 155                 160 


Ala Leu Glu Lys Tyr Lys Glu Glu Asn Asp Asp Phe Ala Ser Phe Arg 
                165                 170                 175     


Val Asp Arg Ile Glu Arg Val Ala Arg Val Arg Gly Gly Glu Gly Thr 
            180                 185                 190         


Gly Tyr Phe Val Asp Phe Ser Val Arg Asn Cys Pro Arg His His Phe 
        195                 200                 205             


Pro Arg His Pro Asn Val Phe Gly Phe Cys Arg Ala Asp Leu Phe Tyr 
    210                 215                 220                 


Asp Val Glu Ala Leu Asp Leu Glu Ser Pro Lys Asn Leu Val Ile Asn 
225                 230                 235                 240 


Cys Glu Val Phe Asp Pro Gln Glu His Glu Asn Ile Asn Gly Val Pro 
                245                 250                 255     


Pro His Leu Gly His Pro Phe His Trp Gly Gly His Glu Arg Ser Ser 
            260                 265                 270         


Thr Thr Lys Pro Pro Phe Lys Pro His Gly Ser Arg Asp His His His 
        275                 280                 285             


Pro His Lys Pro His Glu His Gly Pro Pro Pro Pro Pro Asp Glu Arg 
    290                 295                 300                 


Asp His Ser His Gly Pro Pro Leu Pro Gln Gly Pro Pro Pro Leu Leu 
305                 310                 315                 320 


Pro Met Ser Cys Ser Ser Cys Gln His Ala Thr Phe Gly Thr Asn Gly 
                325                 330                 335     


Ala Gln Arg His Ser His Asn Asn Asn Ser Ser Asp Leu His Pro His 
            340                 345                 350         


Lys His His Ser His Glu Gln His Pro His Gly His His Pro His Ala 
        355                 360                 365             


His His Pro His Glu His Asp Thr His Arg Gln His Pro His Gly His 
    370                 375                 380                 


His Pro His Gly His His Pro His Gly His His Pro His Gly His His 
385                 390                 395                 400 


Pro His Gly His His Pro His Cys His Asp Phe Gln Asp Tyr Gly Pro 
                405                 410                 415     


Cys Asp Pro Pro Pro His Asn Gln Gly His Cys Cys His Gly His Gly 
            420                 425                 430         


Pro Pro Pro Gly His Leu Arg Arg Arg Gly Pro Gly Lys Gly Pro Arg 
        435                 440                 445             


Pro Phe His Cys Arg Gln Ile Gly Ser Val Tyr Arg Leu Pro Pro Leu 
    450                 455                 460                 


Arg Lys Gly Glu Val Leu Pro Leu Pro Glu Ala Asn Phe Pro Ser Phe 
465                 470                 475                 480 


Pro Leu Pro His His Lys His Pro Leu Lys Pro Asp Asn Gln Pro Phe 
                485                 490                 495     


Pro Gln Ser Val Ser Glu Ser Cys Pro Gly Lys Phe Lys Ser Gly Phe 
            500                 505                 510         


Pro Gln Val Ser Met Phe Phe Thr His Thr Phe Pro Lys 
        515                 520                 525 


<210>  6567
<211>  111
<212>  PRT
<213>  Homo Sapiens

<400>  6567

Met Asp Gly Pro Arg Gln Asp Ala Thr Leu Asp Glu Glu Glu Asp Met 
1               5                   10                  15      


Val Ile Ile Tyr Asn Arg Val Pro Lys Thr Ala Ser Thr Ser Phe Thr 
            20                  25                  30          


Asn Ile Ala Tyr Asp Leu Cys Ala Lys Asn Lys Tyr His Val Leu His 
        35                  40                  45              


Ile Asn Thr Thr Lys Asn Asn Pro Val Met Ser Leu Gln Asp Gln Val 
    50                  55                  60                  


Arg Phe Val Lys Asn Ile Thr Ser Trp Lys Glu Met Lys Pro Gly Phe 
65                  70                  75                  80  


Tyr His Gly His Val Ser Tyr Leu Asp Phe Ala Lys Phe Gly Val Lys 
                85                  90                  95      


Lys Lys Pro Ile Tyr Ile Asn Val Ile Arg Asp Pro Ile Glu Arg 
            100                 105                 110     


<210>  6568
<211>  229
<212>  PRT
<213>  Homo Sapiens

<400>  6568

Met Gly Leu Leu Arg Ile Met Met Pro Pro Lys Leu Gln Leu Leu Ala 
1               5                   10                  15      


Val Val Ala Phe Ala Val Ala Met Leu Phe Leu Glu Asn Gln Ile Gln 
            20                  25                  30          


Lys Leu Glu Glu Ser Arg Ser Lys Leu Glu Arg Ala Ile Ala Arg His 
        35                  40                  45              


Glu Val Arg Glu Ile Glu Gln Arg His Thr Met Asp Gly Pro Arg Gln 
    50                  55                  60                  


Asp Ala Thr Leu Asp Glu Glu Glu Asp Met Val Ile Ile Tyr Asn Arg 
65                  70                  75                  80  


Val Pro Lys Thr Ala Ser Thr Ser Phe Thr Asn Ile Ala Tyr Asp Leu 
                85                  90                  95      


Cys Ala Lys Asn Lys Tyr His Val Leu His Ile Asn Thr Thr Lys Asn 
            100                 105                 110         


Asn Pro Val Met Ser Leu Gln Asp Gln Val Arg Phe Val Lys Asn Ile 
        115                 120                 125             


Thr Ser Trp Lys Glu Met Lys Pro Gly Phe Tyr His Gly His Val Ser 
    130                 135                 140                 


Tyr Leu Asp Phe Ala Lys Phe Gly Val Lys Lys Lys Pro Ile Tyr Ile 
145                 150                 155                 160 


Asn Val Ile Arg Asp Pro Ile Glu Arg Leu Val Ser Tyr Tyr Tyr Phe 
                165                 170                 175     


Leu Arg Phe Gly Asp Asp Tyr Arg Pro Gly Leu Arg Arg Arg Lys Gln 
            180                 185                 190         


Gly Asp Lys Lys Thr Phe Asp Glu Cys Val Ala Glu Gly Gly Ser Asp 
        195                 200                 205             


Cys Ala Pro Glu Lys Leu Trp Leu Gln Ile Pro Phe Phe Cys Gly His 
    210                 215                 220                 


Ser Ser Glu Cys Trp 
225                 


<210>  6569
<211>  356
<212>  PRT
<213>  Homo Sapiens

<400>  6569

Met Gly Leu Leu Arg Ile Met Met Pro Pro Lys Leu Gln Leu Leu Ala 
1               5                   10                  15      


Val Val Ala Phe Ala Val Ala Met Leu Phe Leu Glu Asn Gln Ile Gln 
            20                  25                  30          


Lys Leu Glu Glu Ser Arg Ser Lys Leu Glu Arg Ala Ile Ala Arg His 
        35                  40                  45              


Glu Val Arg Glu Ile Glu Gln Arg His Thr Met Asp Gly Pro Arg Gln 
    50                  55                  60                  


Asp Ala Thr Leu Asp Glu Glu Glu Asp Met Val Ile Ile Tyr Asn Arg 
65                  70                  75                  80  


Val Pro Lys Thr Ala Ser Thr Ser Phe Thr Asn Ile Ala Tyr Asp Leu 
                85                  90                  95      


Cys Ala Lys Asn Lys Tyr His Val Leu His Ile Asn Thr Thr Lys Asn 
            100                 105                 110         


Asn Pro Val Met Ser Leu Gln Asp Gln Val Arg Phe Val Lys Asn Ile 
        115                 120                 125             


Thr Ser Trp Lys Glu Met Lys Pro Gly Phe Tyr His Gly His Val Ser 
    130                 135                 140                 


Tyr Leu Asp Phe Ala Lys Phe Gly Val Lys Lys Lys Pro Ile Tyr Ile 
145                 150                 155                 160 


Asn Val Ile Arg Asp Pro Ile Glu Arg Leu Val Ser Tyr Tyr Tyr Phe 
                165                 170                 175     


Leu Arg Phe Gly Asp Asp Tyr Arg Pro Gly Leu Arg Arg Arg Lys Gln 
            180                 185                 190         


Gly Asp Lys Lys Thr Phe Asp Glu Cys Val Ala Glu Gly Gly Ser Asp 
        195                 200                 205             


Cys Ala Pro Glu Lys Leu Trp Leu Gln Ile Pro Phe Phe Cys Gly His 
    210                 215                 220                 


Ser Ser Glu Cys Trp Asn Val Gly Ser Arg Trp Ala Met Asp Gln Ala 
225                 230                 235                 240 


Lys Tyr Asn Leu Ile Asn Glu Tyr Phe Leu Val Gly Val Thr Glu Glu 
                245                 250                 255     


Leu Glu Asp Phe Ile Met Leu Leu Glu Ala Ala Leu Pro Arg Phe Phe 
            260                 265                 270         


Arg Gly Ala Thr Glu Leu Tyr Arg Thr Gly Lys Lys Ser His Leu Arg 
        275                 280                 285             


Lys Thr Thr Glu Lys Lys Leu Pro Thr Lys Gln Thr Ile Ala Lys Leu 
    290                 295                 300                 


Gln Gln Ser Asp Ile Trp Lys Met Glu Asn Glu Phe Tyr Glu Phe Ala 
305                 310                 315                 320 


Leu Glu Gln Phe Gln Phe Ile Arg Ala His Ala Val Arg Glu Lys Asp 
                325                 330                 335     


Gly Asp Leu Tyr Ile Leu Ala Gln Asn Phe Phe Tyr Glu Lys Ile Tyr 
            340                 345                 350         


Pro Lys Ser Asn 
        355     


<210>  6570
<211>  83
<212>  PRT
<213>  Homo Sapiens

<400>  6570

Met Ala Ala Leu Leu Leu Gly Ala Val Leu Leu Val Ala Gln Pro Gln 
1               5                   10                  15      


Leu Val Pro Ser Arg Pro Ala Glu Leu Gly Gln Gln Glu Leu Leu Arg 
            20                  25                  30          


Lys Ala Gly Thr Leu Gln Asp Asp Val Arg Asp Gly Val Ala Pro Asn 
        35                  40                  45              


Gly Ser Ala Gln Gln Leu Pro Gln Thr Ile Ile Ile Gly Val Arg Lys 
    50                  55                  60                  


Gly Gly Thr Arg Ala Leu Leu Glu Met Leu Ser Leu His Pro Asp Val 
65                  70                  75                  80  


Ala Ala Ala 
            


<210>  6571
<211>  83
<212>  PRT
<213>  Homo Sapiens

<400>  6571

Met Ala Ala Leu Leu Leu Gly Ala Val Leu Leu Val Ala Gln Pro Gln 
1               5                   10                  15      


Leu Val Pro Ser Arg Pro Ala Glu Leu Gly Gln Gln Glu Leu Leu Arg 
            20                  25                  30          


Lys Ala Gly Thr Leu Gln Asp Asp Val Arg Asp Gly Val Ala Pro Asn 
        35                  40                  45              


Gly Ser Ala Gln Gln Leu Pro Gln Thr Ile Ile Ile Gly Val Arg Lys 
    50                  55                  60                  


Gly Gly Thr Arg Ala Leu Leu Glu Met Leu Ser Leu His Pro Asp Val 
65                  70                  75                  80  


Ala Ala Ala 
            


<210>  6572
<211>  307
<212>  PRT
<213>  Homo Sapiens

<400>  6572

Met Ala Ala Leu Leu Leu Gly Ala Val Leu Leu Val Ala Gln Pro Gln 
1               5                   10                  15      


Leu Val Pro Ser Arg Pro Ala Glu Leu Gly Gln Gln Glu Leu Leu Arg 
            20                  25                  30          


Lys Ala Gly Thr Leu Gln Asp Asp Val Arg Asp Gly Val Ala Pro Asn 
        35                  40                  45              


Gly Ser Ala Gln Gln Leu Pro Gln Thr Ile Ile Ile Gly Val Arg Lys 
    50                  55                  60                  


Gly Gly Thr Arg Ala Leu Leu Glu Met Leu Ser Leu His Pro Asp Val 
65                  70                  75                  80  


Ala Ala Ala Glu Asn Glu Val His Phe Phe Asp Trp Glu Glu His Tyr 
                85                  90                  95      


Ser His Gly Leu Gly Trp Tyr Leu Ser Gln Met Pro Phe Ser Trp Pro 
            100                 105                 110         


His Gln Leu Thr Val Glu Lys Thr Pro Ala Tyr Phe Thr Ser Pro Lys 
        115                 120                 125             


Val Pro Glu Arg Val Tyr Ser Met Asn Pro Ser Ile Arg Leu Leu Leu 
    130                 135                 140                 


Ile Leu Arg Asp Pro Ser Glu Arg Val Leu Ser Asp Tyr Thr Gln Val 
145                 150                 155                 160 


Phe Tyr Asn His Met Gln Lys His Lys Pro Tyr Pro Ser Ile Glu Glu 
                165                 170                 175     


Phe Leu Val Arg Asp Gly Arg Leu Asn Val Asp Tyr Lys Ala Leu Asn 
            180                 185                 190         


Arg Ser Leu Tyr His Val His Met Gln Asn Trp Leu Arg Phe Phe Pro 
        195                 200                 205             


Leu Arg His Ile His Ile Val Asp Gly Asp Arg Leu Ile Arg Asp Pro 
    210                 215                 220                 


Phe Pro Glu Ile Gln Lys Val Glu Arg Phe Leu Lys Leu Ser Pro Gln 
225                 230                 235                 240 


Ile Asn Ala Ser Asn Phe Tyr Phe Asn Lys Thr Lys Gly Phe Tyr Cys 
                245                 250                 255     


Leu Arg Asp Ser Gly Arg Asp Arg Cys Leu His Glu Ser Lys Gly Arg 
            260                 265                 270         


Ala His Pro Gln Val Asp Pro Lys Leu Leu Asn Lys Leu His Glu Tyr 
        275                 280                 285             


Phe His Glu Pro Asn Lys Lys Phe Phe Glu Leu Val Gly Arg Thr Phe 
    290                 295                 300                 


Asp Trp His 
305         


<210>  6573
<211>  411
<212>  PRT
<213>  Homo Sapiens

<400>  6573

Met Arg Arg Arg Arg Ala Gly Gly Arg Thr Met Val Glu Arg Ala Ser 
1               5                   10                  15      


Lys Phe Val Leu Val Val Ala Gly Ser Val Cys Phe Met Leu Ile Leu 
            20                  25                  30          


Tyr Gln Tyr Ala Gly Pro Gly Leu Ser Leu Gly Ala Pro Gly Gly Arg 
        35                  40                  45              


Ala Pro Pro Asp Asp Leu Asp Leu Phe Pro Thr Pro Asp Pro His Tyr 
    50                  55                  60                  


Glu Lys Lys Tyr Tyr Phe Pro Val Arg Glu Leu Glu Arg Ser Leu Arg 
65                  70                  75                  80  


Phe Asp Met Lys Gly Asp Asp Val Ile Val Phe Leu His Ile Gln Lys 
                85                  90                  95      


Thr Gly Gly Thr Thr Phe Gly Arg His Leu Val Gln Asn Val Arg Leu 
            100                 105                 110         


Glu Val Pro Cys Asp Cys Arg Pro Gly Gln Lys Lys Cys Thr Cys Tyr 
        115                 120                 125             


Arg Pro Asn Arg Arg Glu Thr Trp Leu Phe Ser Arg Phe Ser Thr Gly 
    130                 135                 140                 


Trp Ser Cys Gly Leu His Ala Asp Trp Thr Glu Leu Thr Asn Cys Val 
145                 150                 155                 160 


Pro Gly Val Leu Asp Arg Arg Asp Ser Ala Ala Leu Arg Thr Pro Arg 
                165                 170                 175     


Lys Phe Tyr Tyr Ile Thr Leu Leu Arg Asp Pro Val Ser Arg Tyr Leu 
            180                 185                 190         


Ser Glu Trp Arg His Val Gln Arg Gly Ala Thr Trp Lys Thr Ser Leu 
        195                 200                 205             


His Met Cys Asp Gly Arg Thr Pro Thr Pro Glu Glu Leu Pro Pro Cys 
    210                 215                 220                 


Tyr Glu Gly Thr Asp Trp Ser Gly Cys Thr Leu Gln Glu Phe Met Asp 
225                 230                 235                 240 


Cys Pro Tyr Asn Leu Ala Asn Asn Arg Gln Val Arg Met Leu Ala Asp 
                245                 250                 255     


Leu Ser Leu Val Gly Cys Tyr Asn Leu Ser Phe Ile Pro Glu Gly Lys 
            260                 265                 270         


Arg Ala Gln Leu Leu Leu Glu Ser Ala Lys Lys Asn Leu Arg Gly Met 
        275                 280                 285             


Ala Phe Phe Gly Leu Thr Glu Phe Gln Arg Lys Thr Gln Tyr Leu Phe 
    290                 295                 300                 


Glu Arg Thr Phe Asn Leu Lys Phe Ile Arg Pro Phe Met Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Arg Ala Gly Gly Val Glu Val Asp Glu Asp Thr Ile Arg Arg 
                325                 330                 335     


Ile Glu Glu Leu Asn Asp Leu Asp Met Gln Leu Tyr Asp Tyr Ala Lys 
            340                 345                 350         


Asp Leu Phe Gln Gln Arg Tyr Gln Tyr Lys Arg Gln Leu Glu Arg Arg 
        355                 360                 365             


Glu Gln Arg Leu Arg Ser Arg Glu Glu Arg Leu Leu His Arg Ala Lys 
    370                 375                 380                 


Glu Ala Leu Pro Arg Glu Asp Ala Asp Glu Pro Gly Arg Val Pro Thr 
385                 390                 395                 400 


Glu Asp Tyr Met Ser His Ile Ile Glu Lys Trp 
                405                 410     


<210>  6574
<211>  471
<212>  PRT
<213>  Homo Sapiens

<400>  6574

Met Asp Glu Arg Phe Asn Lys Trp Leu Leu Thr Pro Val Leu Thr Leu 
1               5                   10                  15      


Leu Phe Val Val Ile Met Tyr Gln Tyr Val Ser Pro Ser Cys Thr Ser 
            20                  25                  30          


Ser Cys Thr Asn Phe Gly Glu Gln Pro Arg Ala Gly Glu Ala Gly Pro 
        35                  40                  45              


Pro Ala Val Pro Gly Pro Ala Arg Arg Ala Gln Ala Pro Pro Glu Glu 
    50                  55                  60                  


Trp Glu Arg Arg Pro Gln Leu Pro Pro Pro Pro Arg Gly Pro Pro Glu 
65                  70                  75                  80  


Gly Pro Arg Gly Ala Ala Ala Pro Glu Glu Glu Asp Glu Glu Pro Gly 
                85                  90                  95      


Asp Pro Arg Glu Gly Glu Glu Glu Glu Glu Glu Asp Glu Pro Asp Pro 
            100                 105                 110         


Glu Ala Pro Glu Asn Gly Ser Leu Pro Arg Phe Val Pro Arg Phe Asn 
        115                 120                 125             


Phe Ser Leu Lys Asp Leu Thr Arg Phe Val Asp Phe Asn Ile Lys Gly 
    130                 135                 140                 


Arg Asp Val Ile Val Phe Leu His Ile Gln Lys Thr Gly Gly Thr Thr 
145                 150                 155                 160 


Phe Gly Arg His Leu Val Lys Asn Ile Arg Leu Glu Gln Pro Cys Ser 
                165                 170                 175     


Cys Lys Ala Gly Gln Lys Lys Cys Thr Cys His Arg Pro Gly Lys Lys 
            180                 185                 190         


Glu Thr Trp Leu Phe Ser Arg Phe Ser Thr Gly Trp Ser Cys Gly Leu 
        195                 200                 205             


His Ala Asp Trp Thr Glu Leu Thr Asn Cys Val Pro Ala Ile Met Glu 
    210                 215                 220                 


Lys Lys Asp Cys Pro Arg Asn His Ser His Thr Arg Asn Phe Tyr Tyr 
225                 230                 235                 240 


Ile Thr Met Leu Arg Asp Pro Val Ser Arg Tyr Leu Ser Glu Trp Lys 
                245                 250                 255     


His Val Gln Arg Gly Ala Thr Trp Lys Thr Ser Leu His Met Cys Asp 
            260                 265                 270         


Gly Arg Ser Pro Thr Pro Asp Glu Leu Pro Thr Cys Tyr Pro Gly Asp 
        275                 280                 285             


Asp Trp Ser Gly Val Ser Leu Arg Glu Phe Met Asp Cys Thr Tyr Asn 
    290                 295                 300                 


Leu Ala Asn Asn Arg Gln Val Arg Met Leu Ala Asp Leu Ser Leu Val 
305                 310                 315                 320 


Gly Cys Tyr Asn Leu Thr Phe Met Asn Glu Ser Glu Arg Asn Thr Ile 
                325                 330                 335     


Leu Leu Gln Ser Ala Lys Asn Asn Leu Lys Asn Met Ala Phe Phe Gly 
            340                 345                 350         


Leu Thr Glu Phe Gln Arg Lys Thr Gln Phe Leu Phe Glu Arg Thr Phe 
        355                 360                 365             


Asn Leu Lys Phe Ile Ser Pro Phe Thr Gln Phe Asn Ile Thr Arg Ala 
    370                 375                 380                 


Ser Asn Val Glu Ile Asn Glu Gly Ala Arg Gln Arg Ile Glu Asp Leu 
385                 390                 395                 400 


Asn Phe Leu Asp Met Gln Leu Tyr Glu Tyr Ala Lys Asp Leu Phe Gln 
                405                 410                 415     


Gln Arg Tyr His His Thr Lys Gln Leu Glu His Gln Arg Asp Arg Gln 
            420                 425                 430         


Lys Arg Arg Glu Glu Arg Arg Leu Gln Arg Glu His Arg Asp His Gln 
        435                 440                 445             


Trp Pro Lys Glu Asp Gly Ala Ala Glu Gly Thr Val Thr Glu Asp Tyr 
    450                 455                 460                 


Asn Ser Gln Val Val Arg Trp 
465                 470     


<210>  6575
<211>  236
<212>  PRT
<213>  Homo Sapiens

<400>  6575

Arg Asn Phe Tyr Tyr Ile Thr Met Leu Arg Asp Pro Val Ser Arg Tyr 
1               5                   10                  15      


Leu Ser Glu Trp Lys His Val Gln Arg Gly Ala Thr Trp Lys Thr Ser 
            20                  25                  30          


Leu His Met Cys Asp Gly Arg Ser Pro Thr Pro Asp Glu Leu Pro Thr 
        35                  40                  45              


Cys Tyr Pro Gly Asp Asp Trp Ser Gly Val Ser Leu Arg Glu Phe Met 
    50                  55                  60                  


Asp Cys Thr Tyr Asn Leu Ala Asn Asn Arg Gln Val Arg Met Leu Ala 
65                  70                  75                  80  


Asp Leu Ser Leu Val Gly Cys Tyr Asn Leu Thr Phe Met Asn Glu Ser 
                85                  90                  95      


Glu Arg Asn Thr Ile Leu Leu Gln Ser Ala Lys Asn Asn Leu Lys Asn 
            100                 105                 110         


Met Ala Phe Phe Gly Leu Thr Glu Phe Gln Arg Lys Thr Gln Phe Leu 
        115                 120                 125             


Phe Glu Arg Thr Phe Asn Leu Lys Phe Ile Ser Pro Phe Thr Gln Phe 
    130                 135                 140                 


Asn Ile Thr Arg Ala Ser Asn Val Glu Ile Asn Glu Gly Ala Arg Gln 
145                 150                 155                 160 


Arg Ile Glu Asp Leu Asn Phe Leu Asp Met Gln Leu Tyr Glu Tyr Ala 
                165                 170                 175     


Lys Asp Leu Phe Gln Gln Arg Tyr His His Thr Lys Gln Leu Glu His 
            180                 185                 190         


Gln Arg Asp Arg Gln Lys Arg Arg Glu Glu Arg Arg Leu Gln Arg Glu 
        195                 200                 205             


His Arg Asp His Gln Trp Pro Lys Glu Asp Gly Ala Ala Glu Gly Thr 
    210                 215                 220                 


Val Thr Glu Asp Tyr Asn Ser Gln Val Val Arg Trp 
225                 230                 235     


<210>  6576
<211>  333
<212>  PRT
<213>  Homo Sapiens

<400>  6576

Met Ala Asn Leu Gly Thr Leu Gln Leu Leu Pro Pro Arg Phe Lys Arg 
1               5                   10                  15      


Phe Ser Cys Leu Ser Leu Pro Asn Ile Trp Ile Thr Gly Met Pro Val 
            20                  25                  30          


Pro Ala Thr Ser Val Pro Cys Pro Ser Ala Gly Pro His Arg Thr Met 
        35                  40                  45              


Lys Val Leu Leu Leu Thr Gly Leu Gly Ala Leu Phe Phe Ala Tyr Tyr 
    50                  55                  60                  


Trp Asp Asp Asn Phe Asp Pro Ala Ser Leu Gln Gly Ala Arg Val Leu 
65                  70                  75                  80  


Leu Thr Gly Ala Asn Ala Gly Val Gly Glu Glu Leu Ala Tyr His Tyr 
                85                  90                  95      


Ala Arg Leu Gly Ser His Leu Val Leu Thr Ala His Thr Glu Ala Leu 
            100                 105                 110         


Leu Gln Lys Val Val Gly Asn Cys Arg Lys Leu Gly Ala Pro Lys Val 
        115                 120                 125             


Phe Tyr Ile Ala Ala Asp Met Ala Ser Pro Glu Ala Pro Glu Ser Val 
    130                 135                 140                 


Val Gln Phe Ala Leu Asp Lys Leu Gly Gly Leu Asp Tyr Leu Val Leu 
145                 150                 155                 160 


Asn His Ile Gly Gly Ala Pro Ala Gly Thr Arg Ala Arg Ser Pro Gln 
                165                 170                 175     


Ala Thr Arg Trp Leu Met Gln Val Asn Phe Val Ser Tyr Val Gln Leu 
            180                 185                 190         


Thr Ser Arg Ala Leu Pro Ser Leu Thr Asp Ser Lys Gly Ser Leu Val 
        195                 200                 205             


Val Val Ser Ser Leu Leu Gly Arg Val Pro Thr Ser Phe Ser Thr Pro 
    210                 215                 220                 


Tyr Ser Ala Ala Lys Phe Ala Leu Asp Gly Phe Phe Gly Ser Leu Arg 
225                 230                 235                 240 


Arg Glu Leu Asp Val Gln Asp Val Asn Val Ala Ile Thr Met Cys Val 
                245                 250                 255     


Leu Gly Leu Arg Asp Arg Ala Ser Ala Ala Glu Ala Val Arg Gly Val 
            260                 265                 270         


Thr Arg Val Lys Ala Ala Pro Gly Pro Lys Ala Ala Leu Ala Val Ile 
        275                 280                 285             


Arg Gly Gly Ala Thr Arg Ala Ala Gly Val Phe Tyr Pro Trp Arg Phe 
    290                 295                 300                 


Arg Leu Leu Cys Leu Leu Arg Arg Trp Leu Pro Arg Pro Arg Ala Trp 
305                 310                 315                 320 


Phe Ile Arg Gln Glu Leu Asn Val Thr Ala Ala Ala Ala 
                325                 330             


<210>  6577
<211>  199
<212>  PRT
<213>  Homo Sapiens

<400>  6577

Met Ala Ser Pro Glu Ala Pro Glu Ser Val Val Gln Phe Ala Leu Asp 
1               5                   10                  15      


Lys Leu Gly Gly Leu Asp Tyr Leu Val Leu Asn His Ile Gly Gly Ala 
            20                  25                  30          


Pro Ala Gly Thr Arg Ala Arg Ser Pro Gln Ala Thr Arg Trp Leu Met 
        35                  40                  45              


Gln Val Asn Phe Val Ser Tyr Val Gln Leu Thr Ser Arg Ala Leu Pro 
    50                  55                  60                  


Ser Leu Thr Asp Ser Lys Gly Ser Leu Val Val Val Ser Ser Leu Leu 
65                  70                  75                  80  


Gly Arg Val Pro Thr Ser Phe Ser Thr Pro Tyr Ser Ala Ala Lys Phe 
                85                  90                  95      


Ala Leu Asp Gly Phe Phe Gly Ser Leu Arg Arg Glu Leu Asp Val Gln 
            100                 105                 110         


Asp Val Asn Val Ala Ile Thr Met Cys Val Leu Gly Leu Arg Asp Arg 
        115                 120                 125             


Ala Ser Ala Ala Glu Ala Val Arg Gly Val Thr Arg Val Lys Ala Ala 
    130                 135                 140                 


Pro Gly Pro Lys Ala Ala Leu Ala Val Ile Arg Gly Gly Ala Thr Arg 
145                 150                 155                 160 


Ala Ala Gly Val Phe Tyr Pro Trp Arg Phe Arg Leu Leu Cys Leu Leu 
                165                 170                 175     


Arg Arg Trp Leu Pro Arg Pro Arg Ala Trp Phe Ile Arg Gln Glu Leu 
            180                 185                 190         


Asn Val Thr Ala Ala Ala Ala 
        195                 


<210>  6578
<211>  75
<212>  PRT
<213>  Homo Sapiens

<400>  6578

Met Lys Val Leu Leu Leu Thr Gly Leu Gly Ala Leu Phe Phe Ala Tyr 
1               5                   10                  15      


Tyr Trp Asp Asp Asn Phe Asp Pro Ala Ser Leu Gln Gly Ala Arg Val 
            20                  25                  30          


Leu Leu Thr Gly Ala Asn Ala Gly Val Gly Glu Glu Leu Ala Tyr His 
        35                  40                  45              


Tyr Ala Arg Leu Gly Ser His Leu Val Leu Thr Ala His Thr Glu Ala 
    50                  55                  60                  


Leu Leu Gln Lys Ala Gly Trp Thr Thr Ser Cys 
65                  70                  75  


<210>  6579
<211>  75
<212>  PRT
<213>  Homo Sapiens

<400>  6579

Met Lys Val Leu Leu Leu Thr Gly Leu Gly Ala Leu Phe Phe Ala Tyr 
1               5                   10                  15      


Tyr Trp Asp Asp Asn Phe Asp Pro Ala Ser Leu Gln Gly Ala Arg Val 
            20                  25                  30          


Leu Leu Thr Gly Ala Asn Ala Gly Val Gly Glu Glu Leu Ala Tyr His 
        35                  40                  45              


Tyr Ala Arg Leu Gly Ser His Leu Val Leu Thr Ala His Thr Glu Ala 
    50                  55                  60                  


Leu Leu Gln Lys Ala Gly Trp Thr Thr Ser Cys 
65                  70                  75  


<210>  6580
<211>  87
<212>  PRT
<213>  Homo Sapiens

<400>  6580

Met Lys Val Leu Leu Leu Thr Gly Leu Gly Ala Leu Phe Phe Ala Tyr 
1               5                   10                  15      


Tyr Trp Asp Asp Asn Phe Asp Pro Ala Ser Leu Gln Gly Ala Arg Val 
            20                  25                  30          


Leu Leu Thr Gly Ala Asn Ala Gly Val Gly Glu Glu Leu Ala Tyr His 
        35                  40                  45              


Tyr Ala Arg Leu Gly Ser His Leu Val Leu Thr Ala His Thr Glu Ala 
    50                  55                  60                  


Leu Leu Gln Lys Ala Arg Trp Leu Thr Leu Val Val Ser Thr Leu Gly 
65                  70                  75                  80  


Gly Arg Gly Lys Trp Ile Thr 
                85          


<210>  6581
<211>  143
<212>  PRT
<213>  Homo Sapiens

<400>  6581

Met Lys Val Leu Leu Leu Thr Gly Leu Gly Ala Leu Phe Phe Ala Tyr 
1               5                   10                  15      


Tyr Trp Asp Asp Asn Phe Asp Pro Ala Ser Leu Gln Gly Ala Arg Val 
            20                  25                  30          


Leu Leu Thr Gly Ala Asn Ala Gly Val Gly Glu Glu Leu Ala Tyr His 
        35                  40                  45              


Tyr Ala Arg Leu Gly Ser His Leu Val Leu Thr Ala His Thr Glu Ala 
    50                  55                  60                  


Leu Leu Gln Lys Val Val Gly Asn Cys Arg Lys Leu Gly Ala Pro Lys 
65                  70                  75                  80  


Val Phe Tyr Ile Ala Ala Asp Met Ala Ser Pro Glu Ala Pro Glu Ser 
                85                  90                  95      


Val Val Gln Phe Ala Leu Asp Lys Leu Gly Gly Leu Asp Tyr Leu Val 
            100                 105                 110         


Leu Asn His Ile Gly Gly Ala Pro Ala Gly Thr Arg Ala Arg Ser Pro 
        115                 120                 125             


Gln Ala Thr Arg Trp Leu Met Gln Val Asn Phe Val Ser Tyr Val 
    130                 135                 140             


<210>  6582
<211>  286
<212>  PRT
<213>  Homo Sapiens

<400>  6582

Met Lys Val Leu Leu Leu Thr Gly Leu Gly Ala Leu Phe Phe Ala Tyr 
1               5                   10                  15      


Tyr Trp Asp Asp Asn Phe Asp Pro Ala Ser Leu Gln Gly Ala Arg Val 
            20                  25                  30          


Leu Leu Thr Gly Ala Asn Ala Gly Val Gly Glu Glu Leu Ala Tyr His 
        35                  40                  45              


Tyr Ala Arg Leu Gly Ser His Leu Val Leu Thr Ala His Thr Glu Ala 
    50                  55                  60                  


Leu Leu Gln Lys Val Val Gly Asn Cys Arg Lys Leu Gly Ala Pro Lys 
65                  70                  75                  80  


Val Phe Tyr Ile Ala Ala Asp Met Ala Ser Pro Glu Ala Pro Glu Ser 
                85                  90                  95      


Val Val Gln Phe Ala Leu Asp Lys Leu Gly Gly Leu Asp Tyr Leu Val 
            100                 105                 110         


Leu Asn His Ile Gly Gly Ala Pro Ala Gly Thr Arg Ala Arg Ser Pro 
        115                 120                 125             


Gln Ala Thr Arg Trp Leu Met Gln Val Asn Phe Val Ser Tyr Val Gln 
    130                 135                 140                 


Leu Thr Ser Arg Ala Leu Pro Ser Leu Thr Asp Ser Lys Gly Ser Leu 
145                 150                 155                 160 


Val Val Val Ser Ser Leu Leu Gly Arg Val Pro Thr Ser Phe Ser Thr 
                165                 170                 175     


Pro Tyr Ser Ala Ala Lys Phe Ala Leu Asp Gly Phe Phe Gly Ser Leu 
            180                 185                 190         


Arg Arg Glu Leu Asp Val Gln Asp Val Asn Val Ala Ile Thr Met Cys 
        195                 200                 205             


Val Leu Gly Leu Arg Asp Arg Ala Ser Ala Ala Glu Ala Val Arg Gly 
    210                 215                 220                 


Val Thr Arg Val Lys Ala Ala Pro Gly Pro Lys Ala Ala Leu Ala Val 
225                 230                 235                 240 


Ile Arg Gly Gly Ala Thr Arg Ala Ala Gly Val Phe Tyr Pro Trp Arg 
                245                 250                 255     


Phe Arg Leu Leu Cys Leu Leu Arg Arg Trp Leu Pro Arg Pro Arg Ala 
            260                 265                 270         


Trp Phe Ile Arg Gln Glu Leu Asn Val Thr Ala Ala Ala Ala 
        275                 280                 285     


<210>  6583
<211>  286
<212>  PRT
<213>  Homo Sapiens

<400>  6583

Met Lys Val Leu Leu Leu Thr Gly Leu Gly Ala Leu Phe Phe Ala Tyr 
1               5                   10                  15      


Tyr Trp Asp Asp Asn Phe Asp Pro Ala Ser Leu Gln Gly Ala Arg Val 
            20                  25                  30          


Leu Leu Thr Gly Ala Asn Ala Gly Val Gly Glu Glu Leu Ala Tyr His 
        35                  40                  45              


Tyr Ala Arg Leu Gly Ser His Leu Val Leu Thr Ala His Thr Glu Ala 
    50                  55                  60                  


Leu Leu Gln Lys Val Val Gly Asn Cys Arg Lys Leu Gly Ala Pro Lys 
65                  70                  75                  80  


Val Phe Tyr Ile Ala Ala Asp Met Ala Ser Pro Glu Ala Pro Glu Ser 
                85                  90                  95      


Val Val Gln Phe Ala Leu Asp Lys Leu Gly Gly Leu Asp Tyr Leu Val 
            100                 105                 110         


Leu Asn His Ile Gly Gly Ala Pro Ala Gly Thr Arg Ala Arg Ser Pro 
        115                 120                 125             


Gln Ala Thr Arg Trp Leu Met Gln Val Asn Phe Val Ser Tyr Val Gln 
    130                 135                 140                 


Leu Thr Ser Arg Ala Leu Pro Ser Leu Thr Asp Ser Lys Gly Ser Leu 
145                 150                 155                 160 


Val Val Val Ser Ser Leu Leu Gly Arg Val Pro Thr Ser Phe Ser Thr 
                165                 170                 175     


Pro Tyr Ser Ala Ala Lys Phe Ala Leu Asp Gly Phe Phe Gly Ser Leu 
            180                 185                 190         


Arg Arg Glu Leu Asp Val Gln Asp Val Asn Val Ala Ile Thr Met Cys 
        195                 200                 205             


Val Leu Gly Leu Arg Asp Arg Ala Ser Ala Ala Glu Ala Val Arg Gly 
    210                 215                 220                 


Val Thr Arg Val Lys Ala Ala Pro Gly Pro Lys Ala Ala Leu Ala Val 
225                 230                 235                 240 


Ile Arg Gly Gly Ala Thr Arg Ala Ala Gly Val Phe Tyr Pro Trp Arg 
                245                 250                 255     


Phe Arg Leu Leu Cys Leu Leu Arg Arg Trp Leu Pro Arg Pro Arg Ala 
            260                 265                 270         


Trp Phe Ile Arg Gln Glu Leu Asn Val Thr Ala Ala Ala Ala 
        275                 280                 285     


<210>  6584
<211>  286
<212>  PRT
<213>  Homo Sapiens

<400>  6584

Met Lys Val Leu Leu Leu Thr Gly Leu Gly Ala Leu Phe Phe Ala Tyr 
1               5                   10                  15      


Tyr Trp Asp Asp Asn Phe Asp Pro Ala Ser Leu Gln Gly Ala Arg Val 
            20                  25                  30          


Leu Leu Thr Gly Ala Asn Ala Gly Val Gly Glu Glu Leu Ala Tyr His 
        35                  40                  45              


Tyr Ala Arg Leu Gly Ser His Leu Val Leu Thr Ala His Thr Glu Ala 
    50                  55                  60                  


Leu Leu Gln Lys Val Val Gly Asn Cys Arg Lys Leu Gly Ala Pro Lys 
65                  70                  75                  80  


Val Phe Tyr Ile Ala Ala Asp Met Ala Ser Pro Glu Ala Pro Glu Ser 
                85                  90                  95      


Val Val Gln Phe Ala Leu Asp Lys Leu Gly Gly Leu Asp Tyr Leu Val 
            100                 105                 110         


Leu Asn His Ile Gly Gly Ala Pro Ala Gly Thr Arg Ala Arg Ser Pro 
        115                 120                 125             


Gln Ala Thr Arg Trp Leu Met Gln Val Asn Phe Val Ser Tyr Val Gln 
    130                 135                 140                 


Leu Thr Ser Arg Ala Leu Pro Ser Leu Thr Asp Ser Lys Gly Ser Leu 
145                 150                 155                 160 


Val Val Val Ser Ser Leu Leu Gly Arg Val Pro Thr Ser Phe Ser Thr 
                165                 170                 175     


Pro Tyr Ser Ala Ala Lys Phe Ala Leu Asp Gly Phe Phe Gly Ser Leu 
            180                 185                 190         


Arg Arg Glu Leu Asp Val Gln Asp Val Asn Val Ala Ile Thr Met Cys 
        195                 200                 205             


Val Leu Gly Leu Arg Asp Arg Ala Ser Ala Ala Glu Ala Val Arg Gly 
    210                 215                 220                 


Val Thr Arg Val Lys Ala Ala Pro Gly Pro Lys Ala Ala Leu Ala Val 
225                 230                 235                 240 


Ile Arg Gly Gly Ala Thr Arg Ala Ala Gly Val Phe Tyr Pro Trp Arg 
                245                 250                 255     


Phe Arg Leu Leu Cys Leu Leu Arg Arg Trp Leu Pro Arg Pro Arg Ala 
            260                 265                 270         


Trp Phe Ile Arg Gln Glu Leu Asn Val Thr Ala Ala Ala Ala 
        275                 280                 285     


<210>  6585
<211>  315
<212>  PRT
<213>  Homo Sapiens

<400>  6585

Met Lys Val Leu Leu Leu Thr Gly Leu Gly Ala Leu Phe Phe Ala Tyr 
1               5                   10                  15      


Tyr Trp Asp Asp Asn Phe Asp Pro Ala Ser Leu Gln Gly Ala Arg Val 
            20                  25                  30          


Leu Leu Thr Gly Ala Asn Ala Gly Val Gly Glu Glu Leu Ala Tyr His 
        35                  40                  45              


Tyr Ala Arg Leu Gly Ser His Leu Val Leu Thr Ala His Thr Glu Ala 
    50                  55                  60                  


Leu Leu Gln Lys Val Val Gly Asn Cys Arg Lys Leu Gly Ala Pro Lys 
65                  70                  75                  80  


Val Phe Tyr Ile Ala Ala Asp Met Ala Ser Pro Glu Ala Pro Glu Ser 
                85                  90                  95      


Val Val Gln Phe Ala Leu Asp Lys Leu Gly Gly Leu Asp Tyr Leu Val 
            100                 105                 110         


Leu Asn His Ile Gly Gly Ala Pro Ala Gly Thr Arg Ala Arg Ser Pro 
        115                 120                 125             


Gln Ala Thr Arg Trp Leu Met Gln Val Asn Phe Val Ser Tyr Val Gln 
    130                 135                 140                 


Leu Thr Ser Arg Ala Leu Pro Ser Leu Thr Asp Ser Lys Gly Ser Leu 
145                 150                 155                 160 


Val Val Val Ser Ser Leu Leu Gly Arg Val Pro Thr Ser Phe Ser Thr 
                165                 170                 175     


Pro Tyr Ser Ala Ala Lys Phe Ala Leu Asp Gly Phe Phe Gly Ser Leu 
            180                 185                 190         


Arg Arg Glu Leu Asp Val Gln Asp Val Asn Val Ala Ile Thr Met Cys 
        195                 200                 205             


Val Leu Gly Leu Arg Asp Arg Ala Ser Ala Ala Glu Ala Val Arg Ser 
    210                 215                 220                 


Ser Thr Ser Arg Pro Arg Gln Pro Glu His Arg Gly Val Pro Leu Gln 
225                 230                 235                 240 


Ser Gln Thr Ala Met Phe Leu Pro Pro Thr Val Pro Gly Ala Arg Thr 
                245                 250                 255     


Leu Thr Glu Thr Pro Leu Arg Gly Trp Pro Gln Pro Lys Met Lys Ser 
            260                 265                 270         


Ser Arg Gln Lys Ser Lys Thr Glu Lys Asn Asp Gly His Leu Glu Pro 
        275                 280                 285             


Val Thr Ala Trp Glu Val Gln Val Pro Arg Val Arg Arg Leu Cys Arg 
    290                 295                 300                 


Gly Leu Ala Arg Pro His Leu Phe Gly His Asp 
305                 310                 315 


<210>  6586
<211>  32
<212>  PRT
<213>  Homo Sapiens

<400>  6586

Met Lys Val Leu Leu Leu Thr Gly Leu Gly Ala Leu Phe Phe Ala Tyr 
1               5                   10                  15      


Tyr Trp Asp Asp Asn Phe Asp Pro Ala Ser Arg Glu Arg Glu Cys Cys 
            20                  25                  30          


<210>  6587
<211>  205
<212>  PRT
<213>  Homo Sapiens

<400>  6587

Met Lys Val Leu Leu Leu Thr Gly Leu Gly Ala Leu Phe Phe Ala Tyr 
1               5                   10                  15      


Tyr Trp Asp Asp Asn Phe Asp Pro Gly Gly Leu Asp Tyr Leu Val Leu 
            20                  25                  30          


Asn His Ile Gly Gly Ala Pro Ala Gly Thr Arg Ala Arg Ser Pro Gln 
        35                  40                  45              


Ala Thr Arg Trp Leu Met Gln Val Asn Phe Val Ser Tyr Val Gln Leu 
    50                  55                  60                  


Thr Ser Arg Ala Leu Pro Ser Leu Thr Asp Ser Lys Gly Ser Leu Val 
65                  70                  75                  80  


Val Val Ser Ser Leu Leu Gly Arg Val Pro Thr Ser Phe Ser Thr Pro 
                85                  90                  95      


Tyr Ser Ala Ala Lys Phe Ala Leu Asp Gly Phe Phe Gly Ser Leu Arg 
            100                 105                 110         


Arg Glu Leu Asp Val Gln Asp Val Asn Val Ala Ile Thr Met Cys Val 
        115                 120                 125             


Leu Gly Leu Arg Asp Arg Ala Ser Ala Ala Glu Ala Val Arg Gly Val 
    130                 135                 140                 


Thr Arg Val Lys Ala Ala Pro Gly Pro Lys Ala Ala Leu Ala Val Ile 
145                 150                 155                 160 


Arg Gly Gly Ala Thr Arg Ala Ala Gly Val Phe Tyr Pro Trp Arg Phe 
                165                 170                 175     


Arg Leu Leu Cys Leu Leu Arg Arg Trp Leu Pro Arg Pro Arg Ala Trp 
            180                 185                 190         


Phe Ile Arg Gln Glu Leu Asn Val Thr Ala Ala Ala Ala 
        195                 200                 205 


<210>  6588
<211>  234
<212>  PRT
<213>  Homo Sapiens

<400>  6588

Met Lys Val Leu Leu Leu Thr Gly Leu Gly Ala Leu Phe Phe Ala Tyr 
1               5                   10                  15      


Tyr Trp Asp Asp Asn Phe Asp Pro Gly Gly Leu Asp Tyr Leu Val Leu 
            20                  25                  30          


Asn His Ile Gly Gly Ala Pro Ala Gly Thr Arg Ala Arg Ser Pro Gln 
        35                  40                  45              


Ala Thr Arg Trp Leu Met Gln Val Asn Phe Val Ser Tyr Val Gln Leu 
    50                  55                  60                  


Thr Ser Arg Ala Leu Pro Ser Leu Thr Asp Ser Lys Gly Ser Leu Val 
65                  70                  75                  80  


Val Val Ser Ser Leu Leu Gly Arg Val Pro Thr Ser Phe Ser Thr Pro 
                85                  90                  95      


Tyr Ser Ala Ala Lys Phe Ala Leu Asp Gly Phe Phe Gly Ser Leu Arg 
            100                 105                 110         


Arg Glu Leu Asp Val Gln Asp Val Asn Val Ala Ile Thr Met Cys Val 
        115                 120                 125             


Leu Gly Leu Arg Asp Arg Ala Ser Ala Ala Glu Ala Val Arg Ser Ser 
    130                 135                 140                 


Thr Ser Arg Pro Arg Gln Pro Glu His Arg Gly Val Pro Leu Gln Ser 
145                 150                 155                 160 


Gln Thr Ala Met Phe Leu Pro Pro Thr Val Pro Gly Ala Arg Thr Leu 
                165                 170                 175     


Thr Glu Thr Pro Leu Arg Gly Trp Pro Gln Pro Lys Met Lys Ser Ser 
            180                 185                 190         


Arg Gln Lys Ser Lys Thr Glu Lys Asn Asp Gly His Leu Glu Pro Val 
        195                 200                 205             


Thr Ala Trp Glu Val Gln Val Pro Arg Val Arg Arg Leu Cys Arg Gly 
    210                 215                 220                 


Leu Ala Arg Pro His Leu Phe Gly His Asp 
225                 230                 


<210>  6589
<211>  47
<212>  PRT
<213>  Homo Sapiens

<400>  6589

Met Lys Val Leu Leu Leu Thr Gly Leu Gly Ala Leu Phe Phe Ala Tyr 
1               5                   10                  15      


Tyr Trp Asp Asp Asn Phe Asp Pro Gly Gly Arg Glu Leu Pro Glu Ala 
            20                  25                  30          


Gly Arg Pro Gln Gly Leu Leu His Arg Gly Gly His Gly Leu Pro 
        35                  40                  45          


<210>  6590
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  6590

Met Lys Val Leu Leu Leu Thr Gly Leu Gly Ala Leu Phe Phe Ala Tyr 
1               5                   10                  15      


Tyr Trp Asp Asp Asn Phe Asp Pro Gly Lys Leu Cys Glu Leu Arg Ala 
            20                  25                  30          


Thr Asp Val Ala Gly Ala Ala Gln Pro Asp Gly Gln Gln Gly Leu Pro 
        35                  40                  45              


Gly Gly Gly Val Leu Ala Ala Arg Pro Arg Ala His Val Val Leu His 
    50                  55                  60                  


Ser Leu Leu Gly Gly Gln Val Cys Ala Gly Arg Leu Leu Arg Leu Pro 
65                  70                  75                  80  


Ala Ala Gly Ala Gly Arg Ala Gly Arg Glu Arg Gly His His His Val 
                85                  90                  95      


Arg Pro Gly Pro Pro Arg Ser Arg Leu Arg Arg Arg Gly Ser Gln Gly 
            100                 105                 110         


Ser His Glu Gly Gln Gly Gly Pro Gly Ala Gln Gly Ser Pro Gly Arg 
        115                 120                 125             


Asp Pro Arg Arg Arg His Ala Arg Gly Arg Arg Leu Leu Pro Val Ala 
    130                 135                 140                 


Phe Pro Pro Ala Val Leu Ala Pro Ala Leu Ala Thr Ala Pro Ala Gly 
145                 150                 155                 160 


Leu Val Tyr Pro Pro Gly Ala Gln Arg His Gly Arg Gly Ser Leu Ser 
                165                 170                 175     


Thr Gly Gly Cys Pro Ser Ser Pro Arg Arg Gln Cys Ser 
            180                 185                 


<210>  6591
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  6591

Met Gln Val Asn Phe Val Ser Tyr Val Gln Leu Thr Ser Arg Ala Leu 
1               5                   10                  15      


Pro Ser Leu Thr Asp Ser Lys Gly Ser Leu Val Val Val Ser Ser Leu 
            20                  25                  30          


Leu Gly Arg Val Pro Thr Ser Phe Ser Thr Pro Tyr Ser Ala Ala Lys 
        35                  40                  45              


Phe Ala Leu Asp Gly Phe Phe Gly Ser Leu Arg Arg Glu Leu Asp Val 
    50                  55                  60                  


Gln Asp Val Asn Val Ala Ile Thr Met Cys Val Leu Gly Leu Arg Asp 
65                  70                  75                  80  


Arg Ala Ser Ala Ala Glu Ala Val Arg Gly Val Thr Arg Val Lys Ala 
                85                  90                  95      


Ala Pro Gly Pro Lys Ala Ala Leu Ala Val Ile Arg Gly Gly Ala Thr 
            100                 105                 110         


Arg Ala Ala Gly Val Phe Tyr Pro Trp Arg Phe Arg Leu Leu Cys Leu 
        115                 120                 125             


Leu Arg Arg Trp Leu Pro Arg Pro Arg Ala Trp Phe Ile Arg Gln Glu 
    130                 135                 140                 


Leu Asn Val Thr Ala Ala Ala Ala 
145                 150         


<210>  6592
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  6592

Met Gln Val Asn Phe Val Ser Tyr Val Gln Leu Thr Ser Arg Ala Leu 
1               5                   10                  15      


Pro Ser Leu Thr Asp Ser Lys Gly Ser Leu Val Val Val Ser Ser Leu 
            20                  25                  30          


Leu Gly Arg Val Pro Thr Ser Phe Ser Thr Pro Tyr Ser Ala Ala Lys 
        35                  40                  45              


Phe Ala Leu Asp Gly Phe Phe Gly Ser Leu Arg Arg Glu Leu Asp Val 
    50                  55                  60                  


Gln Asp Val Asn Val Ala Ile Thr Met Cys Val Leu Gly Leu Arg Asp 
65                  70                  75                  80  


Arg Ala Ser Ala Ala Glu Ala Val Arg Gly Val Thr Arg Val Lys Ala 
                85                  90                  95      


Ala Pro Gly Pro Lys Ala Ala Leu Ala Val Ile Arg Gly Gly Ala Thr 
            100                 105                 110         


Arg Ala Ala Gly Val Phe Tyr Pro Trp Arg Phe Arg Leu Leu Cys Leu 
        115                 120                 125             


Leu Arg Arg Trp Leu Pro Arg Pro Arg Ala Trp Phe Ile Arg Gln Glu 
    130                 135                 140                 


Leu Asn Val Thr Ala Ala Ala Ala 
145                 150         


<210>  6593
<211>  181
<212>  PRT
<213>  Homo Sapiens

<400>  6593

Met Gln Val Asn Phe Val Ser Tyr Val Gln Leu Thr Ser Arg Ala Leu 
1               5                   10                  15      


Pro Ser Leu Thr Asp Ser Lys Gly Ser Leu Val Val Val Ser Ser Leu 
            20                  25                  30          


Leu Gly Arg Val Pro Thr Ser Phe Ser Thr Pro Tyr Ser Ala Ala Lys 
        35                  40                  45              


Phe Ala Leu Asp Gly Phe Phe Gly Ser Leu Arg Arg Glu Leu Asp Val 
    50                  55                  60                  


Gln Asp Val Asn Val Ala Ile Thr Met Cys Val Leu Gly Leu Arg Asp 
65                  70                  75                  80  


Arg Ala Ser Ala Ala Glu Ala Val Arg Ser Ser Thr Ser Arg Pro Arg 
                85                  90                  95      


Gln Pro Glu His Arg Gly Val Pro Leu Gln Ser Gln Thr Ala Met Phe 
            100                 105                 110         


Leu Pro Pro Thr Val Pro Gly Ala Arg Thr Leu Thr Glu Thr Pro Leu 
        115                 120                 125             


Arg Gly Trp Pro Gln Pro Lys Met Lys Ser Ser Arg Gln Lys Ser Lys 
    130                 135                 140                 


Thr Glu Lys Asn Asp Gly His Leu Glu Pro Val Thr Ala Trp Glu Val 
145                 150                 155                 160 


Gln Val Pro Arg Val Arg Arg Leu Cys Arg Gly Leu Ala Arg Pro His 
                165                 170                 175     


Leu Phe Gly His Asp 
            180     


<210>  6594
<211>  135
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6594

Xaa Leu Gly Ala Leu Phe Phe Ala Tyr Tyr Trp Asp Asp Asn Phe Asp 
1               5                   10                  15      


Pro Gly Gly Leu Asp Tyr Leu Val Leu Asn His Ile Gly Gly Ala Pro 
            20                  25                  30          


Ala Gly Thr Arg Ala Arg Ser Pro Gln Ala Thr Arg Trp Leu Met Gln 
        35                  40                  45              


Val Asn Phe Val Ser Tyr Val Gln Leu Thr Ser Arg Ala Leu Pro Ser 
    50                  55                  60                  


Leu Thr Asp Ser Lys Gly Ser Leu Val Val Val Ser Ser Leu Leu Gly 
65                  70                  75                  80  


Arg Val Pro Thr Ser Phe Ser Thr Pro Tyr Ser Ala Ala Lys Phe Ala 
                85                  90                  95      


Leu Asp Gly Phe Phe Gly Ser Leu Arg Arg Glu Leu Asp Val Gln Asp 
            100                 105                 110         


Val Asn Val Ala Ile Thr Met Cys Val Leu Gly Leu Arg Asp Arg Ala 
        115                 120                 125             


Ser Ala Ala Glu Ala Val Arg 
    130                 135 


<210>  6595
<211>  256
<212>  PRT
<213>  Homo Sapiens

<400>  6595

Met Lys Phe Leu Leu Asp Ile Leu Leu Leu Leu Pro Leu Leu Ile Val 
1               5                   10                  15      


Cys Ser Leu Glu Ser Phe Val Lys Leu Phe Ile Pro Lys Arg Arg Lys 
            20                  25                  30          


Ser Val Thr Gly Glu Ile Val Leu Ile Thr Gly Ala Gly His Gly Ile 
        35                  40                  45              


Gly Arg Leu Thr Ala Tyr Glu Phe Ala Lys Leu Lys Ser Lys Leu Val 
    50                  55                  60                  


Leu Trp Asp Ile Asn Lys His Gly Leu Glu Glu Thr Ala Ala Lys Cys 
65                  70                  75                  80  


Lys Gly Leu Gly Ala Lys Val His Thr Phe Val Val Asp Cys Ser Asn 
                85                  90                  95      


Arg Glu Asp Ile Tyr Ser Ser Ala Lys Lys Thr Thr Lys Ala Phe Leu 
            100                 105                 110         


Pro Ala Met Thr Lys Asn Asn His Gly His Ile Val Thr Val Ala Ser 
        115                 120                 125             


Ala Ala Gly His Val Ser Val Pro Phe Leu Leu Ala Tyr Cys Ser Ser 
    130                 135                 140                 


Lys Phe Ala Ala Val Gly Phe His Lys Thr Leu Thr Asp Glu Leu Ala 
145                 150                 155                 160 


Ala Leu Gln Ile Thr Gly Val Lys Thr Thr Cys Leu Cys Pro Asn Phe 
                165                 170                 175     


Val Asn Thr Gly Phe Ile Lys Asn Pro Ser Thr Ser Leu Gly Pro Thr 
            180                 185                 190         


Leu Glu Pro Glu Glu Val Val Asn Arg Leu Met His Gly Ile Leu Thr 
        195                 200                 205             


Glu Gln Lys Met Ile Phe Ile Pro Ser Ser Ile Ala Phe Leu Thr Thr 
    210                 215                 220                 


Leu Glu Arg Ile Leu Pro Glu Arg Phe Leu Ala Val Leu Lys Arg Lys 
225                 230                 235                 240 


Ile Ser Val Lys Phe Asp Ala Val Ile Gly Tyr Lys Met Lys Ala Gln 
                245                 250                 255     


<210>  6596
<211>  300
<212>  PRT
<213>  Homo Sapiens

<400>  6596

Met Lys Phe Leu Leu Asp Ile Leu Leu Leu Leu Pro Leu Leu Ile Val 
1               5                   10                  15      


Cys Ser Leu Glu Ser Phe Val Lys Leu Phe Ile Pro Lys Arg Arg Lys 
            20                  25                  30          


Ser Val Thr Gly Glu Ile Val Leu Ile Thr Gly Ala Gly His Gly Ile 
        35                  40                  45              


Gly Arg Leu Thr Ala Tyr Glu Phe Ala Lys Leu Lys Ser Lys Leu Val 
    50                  55                  60                  


Leu Trp Asp Ile Asn Lys His Gly Leu Glu Glu Thr Ala Ala Lys Cys 
65                  70                  75                  80  


Lys Gly Leu Gly Ala Lys Val His Thr Phe Val Val Asp Cys Ser Asn 
                85                  90                  95      


Arg Glu Asp Ile Tyr Ser Ser Ala Lys Lys Val Lys Ala Glu Ile Gly 
            100                 105                 110         


Asp Val Ser Ile Leu Val Asn Asn Ala Gly Val Val Tyr Thr Ser Asp 
        115                 120                 125             


Leu Phe Ala Thr Gln Asp Pro Gln Ile Glu Lys Thr Phe Glu Val Asn 
    130                 135                 140                 


Val Leu Ala His Phe Trp Thr Thr Lys Ala Phe Leu Pro Ala Met Thr 
145                 150                 155                 160 


Lys Asn Asn His Gly His Ile Val Thr Val Ala Ser Ala Ala Gly His 
                165                 170                 175     


Val Ser Val Pro Phe Leu Leu Ala Tyr Cys Ser Ser Lys Phe Ala Ala 
            180                 185                 190         


Val Gly Phe His Lys Thr Leu Thr Asp Glu Leu Ala Ala Leu Gln Ile 
        195                 200                 205             


Thr Gly Val Lys Thr Thr Cys Leu Cys Pro Asn Phe Val Asn Thr Gly 
    210                 215                 220                 


Phe Ile Lys Asn Pro Ser Thr Ser Leu Gly Pro Thr Leu Glu Pro Glu 
225                 230                 235                 240 


Glu Val Val Asn Arg Leu Met His Gly Ile Leu Thr Glu Gln Lys Met 
                245                 250                 255     


Ile Phe Ile Pro Ser Ser Ile Ala Phe Leu Thr Thr Leu Glu Arg Ile 
            260                 265                 270         


Leu Pro Glu Arg Phe Leu Ala Val Leu Lys Arg Lys Ile Ser Val Lys 
        275                 280                 285             


Phe Asp Ala Val Ile Gly Tyr Lys Met Lys Ala Gln 
    290                 295                 300 


<210>  6597
<211>  341
<212>  PRT
<213>  Homo Sapiens

<400>  6597

Met Arg Lys Val Val Leu Ile Thr Gly Ala Ser Ser Gly Ile Gly Leu 
1               5                   10                  15      


Ala Leu Cys Lys Arg Leu Leu Ala Glu Asp Asp Glu Leu His Leu Cys 
            20                  25                  30          


Leu Ala Cys Arg Asn Met Ser Lys Ala Glu Ala Val Cys Ala Ala Leu 
        35                  40                  45              


Leu Ala Ser His Pro Thr Ala Glu Val Thr Ile Val Gln Val Asp Val 
    50                  55                  60                  


Ser Asn Leu Gln Ser Val Phe Arg Ala Ser Lys Glu Leu Lys Gln Arg 
65                  70                  75                  80  


Phe Gln Arg Leu Asp Cys Ile Tyr Leu Asn Ala Gly Ile Met Pro Asn 
                85                  90                  95      


Pro Gln Leu Asn Ile Lys Ala Leu Phe Phe Gly Leu Phe Ser Arg Lys 
            100                 105                 110         


Val Ile His Met Phe Ser Thr Ala Glu Gly Leu Leu Thr Gln Gly Asp 
        115                 120                 125             


Lys Ile Thr Ala Asp Gly Leu Gln Glu Val Phe Glu Thr Asn Val Phe 
    130                 135                 140                 


Gly His Phe Ile Leu Ile Arg Glu Leu Glu Pro Leu Leu Cys His Ser 
145                 150                 155                 160 


Asp Asn Pro Ser Gln Leu Ile Trp Thr Ser Ser Arg Ser Ala Arg Lys 
                165                 170                 175     


Ser Asn Phe Ser Leu Glu Asp Phe Gln His Ser Lys Gly Lys Glu Pro 
            180                 185                 190         


Tyr Ser Ser Ser Lys Tyr Ala Thr Asp Leu Leu Ser Val Ala Leu Asn 
        195                 200                 205             


Arg Asn Phe Asn Gln Gln Gly Leu Tyr Ser Asn Val Ala Cys Pro Gly 
    210                 215                 220                 


Thr Ala Leu Thr Asn Leu Thr Tyr Gly Ile Leu Pro Pro Phe Ile Trp 
225                 230                 235                 240 


Thr Leu Leu Met Pro Ala Ile Leu Leu Leu Arg Phe Phe Ala Asn Ala 
                245                 250                 255     


Phe Thr Leu Thr Pro Tyr Asn Gly Thr Glu Ala Leu Val Trp Leu Phe 
            260                 265                 270         


His Gln Lys Pro Glu Ser Leu Asn Pro Leu Ile Lys Tyr Leu Ser Ala 
        275                 280                 285             


Thr Thr Gly Phe Gly Arg Asn Tyr Ile Met Thr Gln Lys Met Asp Leu 
    290                 295                 300                 


Asp Glu Asp Thr Ala Glu Lys Phe Tyr Gln Lys Leu Leu Glu Leu Glu 
305                 310                 315                 320 


Lys His Ile Arg Val Thr Ile Gln Lys Thr Asp Asn Gln Ala Arg Leu 
                325                 330                 335     


Ser Gly Ser Cys Leu 
            340     


<210>  6598
<211>  111
<212>  PRT
<213>  Homo Sapiens

<400>  6598

Met Arg Lys Val Val Leu Ile Thr Gly Ala Ser Ser Gly Ile Gly Leu 
1               5                   10                  15      


Ala Leu Cys Lys Arg Leu Leu Ala Glu Asp Asp Glu Leu His Leu Cys 
            20                  25                  30          


Leu Ala Cys Arg Asn Met Ser Lys Ala Glu Ala Val Cys Ala Ala Leu 
        35                  40                  45              


Leu Ala Ser His Pro Thr Ala Glu Val Thr Ile Val Gln Val Asp Val 
    50                  55                  60                  


Ser Asn Leu Gln Ser Val Phe Arg Ala Ser Lys Glu Leu Lys Gln Arg 
65                  70                  75                  80  


Phe Gln Arg Leu Asp Cys Ile Tyr Leu Asn Ala Gly Ile Met Pro Asn 
                85                  90                  95      


Pro Gln Leu Asn Ile Lys Ala Leu Phe Phe Gly Leu Phe Ser Ser 
            100                 105                 110     


<210>  6599
<211>  109
<212>  PRT
<213>  Homo Sapiens

<400>  6599

Met Arg Lys Val Val Leu Ile Thr Gly Ala Ser Ser Gly Ile Gly Leu 
1               5                   10                  15      


Ala Leu Cys Lys Arg Leu Leu Ala Glu Asp Asp Glu Leu His Leu Cys 
            20                  25                  30          


Leu Ala Cys Arg Asn Met Ser Lys Ala Glu Ala Val Cys Ala Ala Leu 
        35                  40                  45              


Leu Ala Ser His Pro Thr Ala Glu Val Thr Ile Val Gln Val Asp Val 
    50                  55                  60                  


Ser Asn Leu Gln Ser Val Phe Arg Ala Ser Lys Glu Leu Lys Gln Arg 
65                  70                  75                  80  


Met Ile Lys Lys Trp Leu Tyr Val Ile Cys Val Glu Asp His Val Ser 
                85                  90                  95      


Glu Ile Arg Leu Tyr Ile Ser Lys Cys Trp Asp His Ala 
            100                 105                 


<210>  6600
<211>  84
<212>  PRT
<213>  Homo Sapiens

<400>  6600

Met Arg Lys Val Val Leu Ile Thr Gly Ala Ser Ser Gly Ile Gly Leu 
1               5                   10                  15      


Ala Leu Cys Lys Arg Leu Leu Ala Glu Asp Asp Glu Leu His Leu Cys 
            20                  25                  30          


Leu Ala Cys Arg Asn Met Ser Lys Ala Glu Ala Val Cys Ala Ala Leu 
        35                  40                  45              


Leu Ala Ser His Pro Thr Ala Glu Val Thr Ile Val Gln Val Asp Val 
    50                  55                  60                  


Ser Asn Leu Gln Ser Val Phe Arg Ala Ser Lys Glu Leu Lys Gln Arg 
65                  70                  75                  80  


Tyr Ile Ser Cys 
                


<210>  6601
<211>  62
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6601

Xaa Ser Leu Glu Asp Phe Gln His Ser Lys Gly Lys Glu Pro Tyr Ser 
1               5                   10                  15      


Ser Ser Lys Tyr Ala Thr Asp Leu Leu Ser Val Ala Leu Asn Arg Asn 
            20                  25                  30          


Phe Asn Gln Gln Val Leu Tyr Ser Ser Val Tyr Val Ile Lys Tyr Leu 
        35                  40                  45              


Pro His Tyr Met Glu Val Gly Leu Ser Ile Thr Ile Phe Arg 
    50                  55                  60          


<210>  6602
<211>  49
<212>  PRT
<213>  Homo Sapiens

<400>  6602

Met Met Lys Leu Ile Ile Asn Ser Leu Tyr Lys Asn Lys Glu Ile Phe 
1               5                   10                  15      


Leu Arg Glu Leu Ile Ser Asn Ala Ser Asp Ala Leu Asp Lys Ile Arg 
            20                  25                  30          


Leu Ile Ser Leu Thr Asp Glu Asn Ala Leu Ser Gly Asn Glu Glu Leu 
        35                  40                  45              


Thr 
    


<210>  6603
<211>  803
<212>  PRT
<213>  Homo Sapiens

<400>  6603

Met Arg Ala Leu Trp Val Leu Gly Leu Cys Cys Val Leu Leu Thr Phe 
1               5                   10                  15      


Gly Ser Val Arg Ala Asp Asp Glu Val Asp Val Asp Gly Thr Val Glu 
            20                  25                  30          


Glu Asp Leu Gly Lys Ser Arg Glu Gly Ser Arg Thr Asp Asp Glu Val 
        35                  40                  45              


Val Gln Arg Glu Glu Glu Ala Ile Gln Leu Asp Gly Leu Asn Ala Ser 
    50                  55                  60                  


Gln Ile Arg Glu Leu Arg Glu Lys Ser Glu Lys Phe Ala Phe Gln Ala 
65                  70                  75                  80  


Glu Val Asn Arg Met Met Lys Leu Ile Ile Asn Ser Leu Tyr Lys Asn 
                85                  90                  95      


Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ala Ser Asp Ala Leu 
            100                 105                 110         


Asp Lys Ile Arg Leu Ile Ser Leu Thr Asp Glu Asn Ala Leu Ser Gly 
        115                 120                 125             


Asn Glu Glu Leu Thr Val Lys Ile Lys Cys Asp Lys Glu Lys Asn Leu 
    130                 135                 140                 


Leu His Val Thr Asp Thr Gly Val Gly Met Thr Arg Glu Glu Leu Val 
145                 150                 155                 160 


Lys Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Ser Glu Phe Leu Asn 
                165                 170                 175     


Lys Met Thr Glu Ala Gln Glu Asp Gly Gln Ser Thr Ser Glu Leu Ile 
            180                 185                 190         


Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Phe Leu Val Ala Asp Lys 
        195                 200                 205             


Val Ile Val Thr Ser Lys His Asn Asn Asp Thr Gln His Ile Trp Glu 
    210                 215                 220                 


Ser Asp Ser Asn Glu Phe Ser Val Ile Ala Asp Pro Arg Gly Asn Thr 
225                 230                 235                 240 


Leu Gly Arg Gly Thr Thr Ile Thr Leu Val Leu Lys Glu Glu Ala Ser 
                245                 250                 255     


Asp Tyr Leu Glu Leu Asp Thr Ile Lys Asn Leu Val Lys Lys Tyr Ser 
            260                 265                 270         


Gln Phe Ile Asn Phe Pro Ile Tyr Val Trp Ser Ser Lys Thr Glu Thr 
        275                 280                 285             


Val Glu Glu Pro Met Glu Glu Glu Glu Ala Ala Lys Glu Glu Lys Glu 
    290                 295                 300                 


Glu Ser Asp Asp Glu Ala Ala Val Glu Glu Glu Glu Glu Glu Lys Lys 
305                 310                 315                 320 


Pro Lys Thr Lys Lys Val Glu Lys Thr Val Trp Asp Trp Glu Leu Met 
                325                 330                 335     


Asn Asp Ile Lys Pro Ile Trp Gln Arg Pro Ser Lys Glu Val Glu Glu 
            340                 345                 350         


Asp Glu Tyr Lys Ala Phe Tyr Lys Ser Phe Ser Lys Glu Ser Asp Asp 
        355                 360                 365             


Pro Met Ala Tyr Ile His Phe Thr Ala Glu Gly Glu Val Thr Phe Lys 
    370                 375                 380                 


Ser Ile Leu Phe Val Pro Thr Ser Ala Pro Arg Gly Leu Phe Asp Glu 
385                 390                 395                 400 


Tyr Gly Ser Lys Lys Ser Asp Tyr Ile Lys Leu Tyr Val Arg Arg Val 
                405                 410                 415     


Phe Ile Thr Asp Asp Phe His Asp Met Met Pro Lys Tyr Leu Asn Phe 
            420                 425                 430         


Val Lys Gly Val Val Asp Ser Asp Asp Leu Pro Leu Asn Val Ser Arg 
        435                 440                 445             


Glu Thr Leu Gln Gln His Lys Leu Leu Lys Val Ile Arg Lys Lys Leu 
    450                 455                 460                 


Val Arg Lys Thr Leu Asp Met Ile Lys Lys Ile Ala Asp Asp Lys Tyr 
465                 470                 475                 480 


Asn Asp Thr Phe Trp Lys Glu Phe Gly Thr Asn Ile Lys Leu Gly Val 
                485                 490                 495     


Ile Glu Asp His Ser Asn Arg Thr Arg Leu Ala Lys Leu Leu Arg Phe 
            500                 505                 510         


Gln Ser Ser His His Pro Thr Asp Ile Thr Ser Leu Asp Gln Tyr Val 
        515                 520                 525             


Glu Arg Met Lys Glu Lys Gln Asp Lys Ile Tyr Phe Met Ala Gly Ser 
    530                 535                 540                 


Ser Arg Lys Glu Ala Glu Ser Ser Pro Phe Val Glu Arg Leu Leu Lys 
545                 550                 555                 560 


Lys Gly Tyr Glu Val Ile Tyr Leu Thr Glu Pro Val Asp Glu Tyr Cys 
                565                 570                 575     


Ile Gln Ala Leu Pro Glu Phe Asp Gly Lys Arg Phe Gln Asn Val Ala 
            580                 585                 590         


Lys Glu Gly Val Lys Phe Asp Glu Ser Glu Lys Thr Lys Glu Ser Arg 
        595                 600                 605             


Glu Ala Val Glu Lys Glu Phe Glu Pro Leu Leu Asn Trp Met Lys Asp 
    610                 615                 620                 


Lys Ala Leu Lys Asp Lys Ile Glu Lys Ala Val Val Ser Gln Arg Leu 
625                 630                 635                 640 


Thr Glu Ser Pro Cys Ala Leu Val Ala Ser Gln Tyr Gly Trp Ser Gly 
                645                 650                 655     


Asn Met Glu Arg Ile Met Lys Ala Gln Ala Tyr Gln Thr Gly Lys Asp 
            660                 665                 670         


Ile Ser Thr Asn Tyr Tyr Ala Ser Gln Lys Lys Thr Phe Glu Ile Asn 
        675                 680                 685             


Pro Arg His Pro Leu Ile Arg Asp Met Leu Arg Arg Ile Lys Glu Asp 
    690                 695                 700                 


Glu Asp Asp Lys Thr Val Leu Asp Leu Ala Val Val Leu Phe Glu Thr 
705                 710                 715                 720 


Ala Thr Leu Arg Ser Gly Tyr Leu Leu Pro Asp Thr Lys Ala Tyr Gly 
                725                 730                 735     


Asp Arg Ile Glu Arg Met Leu Arg Leu Ser Leu Asn Ile Asp Pro Asp 
            740                 745                 750         


Ala Lys Val Glu Glu Glu Pro Glu Glu Glu Pro Glu Glu Thr Ala Glu 
        755                 760                 765             


Asp Thr Thr Glu Asp Thr Glu Gln Asp Glu Asp Glu Glu Met Asp Val 
    770                 775                 780                 


Gly Thr Asp Glu Glu Glu Glu Thr Ala Lys Glu Ser Thr Ala Glu Lys 
785                 790                 795                 800 


Asp Glu Leu 
            


<210>  6604
<211>  315
<212>  PRT
<213>  Homo Sapiens

<400>  6604

Met Arg Ala Leu Trp Val Leu Gly Leu Cys Cys Val Leu Leu Thr Phe 
1               5                   10                  15      


Gly Ser Val Arg Ala Asp Asp Glu Val Asp Val Asp Gly Thr Val Glu 
            20                  25                  30          


Glu Asp Leu Gly Lys Ser Arg Glu Gly Ser Arg Thr Asp Asp Glu Val 
        35                  40                  45              


Val Gln Arg Glu Glu Glu Ala Ile Gln Leu Asp Gly Leu Asn Ala Ser 
    50                  55                  60                  


Gln Ile Arg Glu Leu Arg Glu Lys Ser Glu Lys Phe Ala Phe Gln Ala 
65                  70                  75                  80  


Glu Val Asn Arg Met Met Lys Leu Ile Ile Asn Ser Leu Tyr Lys Asn 
                85                  90                  95      


Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ala Ser Asp Ala Leu 
            100                 105                 110         


Asp Lys Ile Arg Leu Ile Ser Leu Thr Asp Glu Asn Ala Leu Ser Gly 
        115                 120                 125             


Asn Glu Glu Leu Thr Val Lys Ile Lys Cys Asp Lys Glu Lys Asn Leu 
    130                 135                 140                 


Leu His Val Thr Asp Thr Gly Val Gly Met Thr Arg Glu Glu Leu Val 
145                 150                 155                 160 


Lys Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Ser Glu Phe Leu Asn 
                165                 170                 175     


Lys Met Thr Glu Ala Gln Glu Asp Gly Gln Ser Thr Ser Glu Leu Ile 
            180                 185                 190         


Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Phe Leu Val Ala Asp Lys 
        195                 200                 205             


Val Ile Val Thr Ser Lys His Asn Asn Asp Thr Gln His Ile Trp Glu 
    210                 215                 220                 


Ser Asp Ser Asn Glu Phe Ser Val Ile Ala Asp Pro Arg Gly Asn Thr 
225                 230                 235                 240 


Leu Gly Arg Gly Thr Thr Ile Thr Leu Val Leu Lys Glu Glu Ala Ser 
                245                 250                 255     


Asp Tyr Leu Glu Leu Asp Thr Ile Lys Asn Leu Val Lys Lys Tyr Ser 
            260                 265                 270         


Gln Phe Ile Asn Phe Pro Ile Tyr Val Trp Ser Ser Lys Thr Glu Thr 
        275                 280                 285             


Val Glu Glu Pro Met Glu Glu Glu Glu Ala Ala Lys Glu Glu Lys Glu 
    290                 295                 300                 


Glu Ser Asp Asp Glu Ala Ala Val Glu Gln Arg 
305                 310                 315 


<210>  6605
<211>  315
<212>  PRT
<213>  Homo Sapiens

<400>  6605

Met Arg Ala Leu Trp Val Leu Gly Leu Cys Cys Val Leu Leu Thr Phe 
1               5                   10                  15      


Gly Ser Val Arg Ala Asp Asp Glu Val Asp Val Asp Gly Thr Val Glu 
            20                  25                  30          


Glu Asp Leu Gly Lys Ser Arg Glu Gly Ser Arg Thr Asp Asp Glu Val 
        35                  40                  45              


Val Gln Arg Glu Glu Glu Ala Ile Gln Leu Asp Gly Leu Asn Ala Ser 
    50                  55                  60                  


Gln Ile Arg Glu Leu Arg Glu Lys Ser Glu Lys Phe Ala Phe Gln Ala 
65                  70                  75                  80  


Glu Val Asn Arg Met Met Lys Leu Ile Ile Asn Ser Leu Tyr Lys Asn 
                85                  90                  95      


Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ala Ser Asp Ala Leu 
            100                 105                 110         


Asp Lys Ile Arg Leu Ile Ser Leu Thr Asp Glu Asn Ala Leu Ser Gly 
        115                 120                 125             


Asn Glu Glu Leu Thr Val Lys Ile Lys Cys Asp Lys Glu Lys Asn Leu 
    130                 135                 140                 


Leu His Val Thr Asp Thr Gly Val Gly Met Thr Arg Glu Glu Leu Val 
145                 150                 155                 160 


Lys Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Ser Glu Phe Leu Asn 
                165                 170                 175     


Lys Met Thr Glu Ala Gln Glu Asp Gly Gln Ser Thr Ser Glu Leu Ile 
            180                 185                 190         


Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Phe Leu Val Ala Asp Lys 
        195                 200                 205             


Val Ile Val Thr Ser Lys His Asn Asn Asp Thr Gln His Ile Trp Glu 
    210                 215                 220                 


Ser Asp Ser Asn Glu Phe Ser Val Ile Ala Asp Pro Arg Gly Asn Thr 
225                 230                 235                 240 


Leu Gly Arg Gly Thr Thr Ile Thr Leu Val Leu Lys Glu Glu Ala Ser 
                245                 250                 255     


Asp Tyr Leu Glu Leu Asp Thr Ile Lys Asn Leu Val Lys Lys Tyr Ser 
            260                 265                 270         


Gln Phe Ile Asn Phe Pro Ile Tyr Val Trp Ser Ser Lys Thr Glu Thr 
        275                 280                 285             


Val Glu Glu Pro Met Glu Glu Glu Glu Ala Ala Lys Glu Glu Lys Glu 
    290                 295                 300                 


Glu Ser Asp Asp Glu Ala Ala Ala Arg Arg Arg 
305                 310                 315 


<210>  6606
<211>  53
<212>  PRT
<213>  Homo Sapiens

<400>  6606

Met Arg Ala Leu Trp Val Leu Gly Leu Cys Cys Val Leu Leu Thr Phe 
1               5                   10                  15      


Gly Ser Val Arg Ala Asp Asp Glu Val Asp Val Asp Gly Thr Val Glu 
            20                  25                  30          


Glu Asp Leu Gly Lys Ser Arg Glu Gly Ser Arg Thr Asp Asp Glu Val 
        35                  40                  45              


Val Gln Arg Ser Arg 
    50              


<210>  6607
<211>  147
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6607

Xaa Gln Tyr Gly Trp Ser Gly Asn Met Glu Arg Ile Met Lys Ala Gln 
1               5                   10                  15      


Ala Tyr Gln Thr Gly Lys Asp Ile Ser Thr Asn Tyr Tyr Ala Ser Gln 
            20                  25                  30          


Lys Lys Thr Phe Glu Ile Asn Pro Arg His Pro Leu Ile Arg Asp Met 
        35                  40                  45              


Leu Arg Arg Ile Lys Glu Asp Glu Asp Asp Lys Thr Val Leu Asp Leu 
    50                  55                  60                  


Ala Val Val Leu Phe Glu Thr Ala Thr Leu Arg Ser Gly Tyr Leu Leu 
65                  70                  75                  80  


Pro Asp Thr Lys Ala Tyr Gly Asp Arg Ile Glu Arg Met Leu Arg Leu 
                85                  90                  95      


Ser Leu Asn Ile Asp Pro Asp Ala Lys Val Glu Glu Glu Pro Glu Glu 
            100                 105                 110         


Glu Pro Glu Glu Thr Ala Glu Asp Thr Thr Glu Asp Thr Glu Gln Asp 
        115                 120                 125             


Glu Asp Glu Glu Met Asp Val Gly Thr Asp Glu Glu Glu Glu Thr Ala 
    130                 135                 140                 


Lys Met Ser 
145         


<210>  6608
<211>  471
<212>  PRT
<213>  Homo Sapiens

<400>  6608

Met Ala Arg Glu Met Thr Ile Leu Gly Ser Ala Val Leu Thr Leu Leu 
1               5                   10                  15      


Leu Ala Gly Tyr Leu Ala Gln Gln Tyr Leu Pro Leu Pro Thr Pro Lys 
            20                  25                  30          


Val Ile Gly Ile Asp Leu Gly Thr Thr Tyr Cys Ser Val Gly Val Phe 
        35                  40                  45              


Phe Pro Gly Thr Gly Lys Val Lys Val Ile Pro Asp Glu Asn Gly His 
    50                  55                  60                  


Ile Ser Ile Pro Ser Met Val Ser Phe Thr Asp Asn Asp Val Tyr Val 
65                  70                  75                  80  


Gly Tyr Glu Ser Val Glu Leu Ala Asp Ser Asn Pro Gln Asn Thr Ile 
                85                  90                  95      


Tyr Asp Ala Lys Arg Phe Ile Gly Lys Ile Phe Thr Ala Glu Glu Leu 
            100                 105                 110         


Glu Ala Glu Ile Gly Arg Tyr Pro Phe Lys Val Leu Asn Lys Asn Gly 
        115                 120                 125             


Met Val Glu Phe Ser Val Thr Ser Asn Glu Thr Ile Thr Val Ser Pro 
    130                 135                 140                 


Glu Tyr Val Gly Ser Arg Leu Leu Leu Lys Leu Lys Glu Met Ala Glu 
145                 150                 155                 160 


Ala Tyr Leu Gly Met Pro Val Ala Asn Ala Val Ile Ser Val Pro Ala 
                165                 170                 175     


Glu Phe Asp Leu Lys Gln Arg Asn Ser Thr Ile Glu Ala Ala Asn Leu 
            180                 185                 190         


Ala Gly Leu Lys Ile Leu Arg Val Ile Asn Glu Pro Thr Ala Ala Ala 
        195                 200                 205             


Met Ala Tyr Gly Leu His Lys Ala Asp Val Phe His Val Leu Val Ile 
    210                 215                 220                 


Asp Leu Gly Gly Gly Thr Leu Asp Val Ser Leu Leu Asn Lys Gln Gly 
225                 230                 235                 240 


Gly Met Phe Leu Thr Arg Ala Met Ser Gly Asn Asn Lys Leu Gly Gly 
                245                 250                 255     


Gln Asp Phe Asn Gln Arg Leu Leu Gln Tyr Leu Tyr Lys Gln Ile Tyr 
            260                 265                 270         


Gln Thr Tyr Gly Phe Val Pro Ser Arg Lys Glu Glu Ile His Arg Leu 
        275                 280                 285             


Arg Gln Ala Val Glu Met Val Lys Leu Asn Leu Thr Leu His Gln Ser 
    290                 295                 300                 


Ala Gln Leu Ser Val Leu Leu Thr Val Glu Glu Gln Asp Arg Lys Glu 
305                 310                 315                 320 


Pro His Ser Ser Asp Thr Glu Leu Pro Lys Asp Lys Leu Ser Ser Ala 
                325                 330                 335     


Asp Asp His Arg Val Asn Ser Gly Phe Gly Arg Gly Leu Ser Asp Lys 
            340                 345                 350         


Lys Ser Gly Glu Ser Gln Val Leu Phe Glu Thr Glu Ile Ser Arg Lys 
        355                 360                 365             


Leu Phe Asp Thr Leu Asn Glu Asp Leu Phe Gln Lys Ile Leu Val Pro 
    370                 375                 380                 


Ile Gln Gln Val Leu Lys Glu Gly His Leu Glu Lys Thr Glu Ile Asp 
385                 390                 395                 400 


Glu Val Val Leu Val Gly Gly Ser Thr Arg Ile Pro Arg Ile Arg Gln 
                405                 410                 415     


Val Ile Gln Glu Phe Phe Gly Lys Asp Pro Asn Thr Ser Val Asp Pro 
            420                 425                 430         


Asp Leu Ala Val Val Thr Gly Val Ala Ile Gln Ala Gly Ile Asp Gly 
        435                 440                 445             


Gly Ser Trp Pro Leu Gln Val Ser Ala Leu Glu Ile Pro Asn Lys His 
    450                 455                 460                 


Leu Gln Lys Thr Asn Phe Asn 
465                 470     


<210>  6609
<211>  654
<212>  PRT
<213>  Homo Sapiens

<400>  6609

Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Arg Ala Glu Glu Glu Asp Lys Lys Glu Asp Val Gly Thr Val Val Gly 
            20                  25                  30          


Ile Asp Leu Gly Thr Thr Tyr Ser Cys Val Gly Val Phe Lys Asn Gly 
        35                  40                  45              


Arg Val Glu Ile Ile Ala Asn Asp Gln Gly Asn Arg Ile Thr Pro Ser 
    50                  55                  60                  


Tyr Val Ala Phe Thr Pro Glu Gly Glu Arg Leu Ile Gly Asp Ala Ala 
65                  70                  75                  80  


Lys Asn Gln Leu Thr Ser Asn Pro Glu Asn Thr Val Phe Asp Ala Lys 
                85                  90                  95      


Arg Leu Ile Gly Arg Thr Trp Asn Asp Pro Ser Val Gln Gln Asp Ile 
            100                 105                 110         


Lys Phe Leu Pro Phe Lys Val Val Glu Lys Lys Thr Lys Pro Tyr Ile 
        115                 120                 125             


Gln Val Asp Ile Gly Gly Gly Gln Thr Lys Thr Phe Ala Pro Glu Glu 
    130                 135                 140                 


Ile Ser Ala Met Val Leu Thr Lys Met Lys Glu Thr Ala Glu Ala Tyr 
145                 150                 155                 160 


Leu Gly Lys Lys Val Thr His Ala Val Val Thr Val Pro Ala Tyr Phe 
                165                 170                 175     


Asn Asp Ala Gln Arg Gln Ala Thr Lys Asp Ala Gly Thr Ile Ala Gly 
            180                 185                 190         


Leu Asn Val Met Arg Ile Ile Asn Glu Pro Thr Ala Ala Ala Ile Ala 
        195                 200                 205             


Tyr Gly Leu Asp Lys Arg Glu Gly Glu Lys Asn Ile Leu Val Phe Asp 
    210                 215                 220                 


Leu Gly Gly Gly Thr Phe Asp Val Ser Leu Leu Thr Ile Asp Asn Gly 
225                 230                 235                 240 


Val Phe Glu Val Val Ala Thr Asn Gly Asp Thr His Leu Gly Gly Glu 
                245                 250                 255     


Asp Phe Asp Gln Arg Val Met Glu His Phe Ile Lys Leu Tyr Lys Lys 
            260                 265                 270         


Lys Thr Gly Lys Asp Val Arg Lys Asp Asn Arg Ala Val Gln Lys Leu 
        275                 280                 285             


Arg Arg Glu Val Glu Lys Ala Lys Arg Ala Leu Ser Ser Gln His Gln 
    290                 295                 300                 


Ala Arg Ile Glu Ile Glu Ser Phe Tyr Glu Gly Glu Asp Phe Ser Glu 
305                 310                 315                 320 


Thr Leu Thr Arg Ala Lys Phe Glu Glu Leu Asn Met Asp Leu Phe Arg 
                325                 330                 335     


Ser Thr Met Lys Pro Val Gln Lys Val Leu Glu Asp Ser Asp Leu Lys 
            340                 345                 350         


Lys Ser Asp Ile Asp Glu Ile Val Leu Val Gly Gly Ser Thr Arg Ile 
        355                 360                 365             


Pro Lys Ile Gln Gln Leu Val Lys Glu Phe Phe Asn Gly Lys Glu Pro 
    370                 375                 380                 


Ser Arg Gly Ile Asn Pro Asp Glu Ala Val Ala Tyr Gly Ala Ala Val 
385                 390                 395                 400 


Gln Ala Gly Val Leu Ser Gly Asp Gln Asp Thr Gly Asp Leu Val Leu 
                405                 410                 415     


Leu Asp Val Cys Pro Leu Thr Leu Gly Ile Glu Thr Val Gly Gly Val 
            420                 425                 430         


Met Thr Lys Leu Ile Pro Arg Asn Thr Val Val Pro Thr Lys Lys Ser 
        435                 440                 445             


Gln Ile Phe Ser Thr Ala Ser Asp Asn Gln Pro Thr Val Thr Ile Lys 
    450                 455                 460                 


Val Tyr Glu Gly Glu Arg Pro Leu Thr Lys Asp Asn His Leu Leu Gly 
465                 470                 475                 480 


Thr Phe Asp Leu Thr Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln 
                485                 490                 495     


Ile Glu Val Thr Phe Glu Ile Asp Val Asn Gly Ile Leu Arg Val Thr 
            500                 505                 510         


Ala Glu Asp Lys Gly Thr Gly Asn Lys Asn Lys Ile Thr Ile Thr Asn 
        515                 520                 525             


Asp Gln Asn Arg Leu Thr Pro Glu Glu Ile Glu Arg Met Val Asn Asp 
    530                 535                 540                 


Ala Glu Lys Phe Ala Glu Glu Asp Lys Lys Leu Lys Glu Arg Ile Asp 
545                 550                 555                 560 


Thr Arg Asn Glu Leu Glu Ser Tyr Ala Tyr Ser Leu Lys Asn Gln Ile 
                565                 570                 575     


Gly Asp Lys Glu Lys Leu Gly Gly Lys Leu Ser Ser Glu Asp Lys Glu 
            580                 585                 590         


Thr Met Glu Lys Ala Val Glu Glu Lys Ile Glu Trp Leu Glu Ser His 
        595                 600                 605             


Gln Asp Ala Asp Ile Glu Asp Phe Lys Ala Lys Lys Lys Glu Leu Glu 
    610                 615                 620                 


Glu Ile Val Gln Pro Ile Ile Ser Lys Leu Tyr Gly Ser Ala Gly Pro 
625                 630                 635                 640 


Pro Pro Thr Gly Glu Glu Asp Thr Ala Glu Lys Asp Glu Leu 
                645                 650                 


<210>  6610
<211>  236
<212>  PRT
<213>  Homo Sapiens

<400>  6610

Ile Ser Thr His Phe Ala Pro Gly Asp Phe Gln Gly Phe Ala Leu Val 
1               5                   10                  15      


Asn Pro Gln Arg Asn Ser Arg Leu Thr Gly Glu Phe Thr Val Glu Pro 
            20                  25                  30          


Val Pro Glu Gly Ala Gln Leu Ser Phe Gly Asn Phe Ala Gln Leu Gly 
        35                  40                  45              


His Glu Ser Phe Tyr Trp Gln Leu Pro Glu Thr Tyr Gln Gly Asp Lys 
    50                  55                  60                  


Gly Glu Ala Tyr Phe Ala Arg Met Arg Arg Ala His Gln Asn Arg Thr 
65                  70                  75                  80  


Ser Leu Ser Glu Glu Gln Leu Arg Ala Ala Val Thr Ala Gly Arg Ile 
                85                  90                  95      


Pro Glu Pro Pro Glu Gly Arg Asp Trp Ala Gln Arg Ala Ser Gln Val 
            100                 105                 110         


Asp Glu Ala Gln Arg Arg Met Asp Ala Glu Ile Trp Gln Leu Leu Ser 
        115                 120                 125             


Ser Phe Ala Ala Gln Pro Gln Pro Pro Pro Gln Gly Leu Ser Pro His 
    130                 135                 140                 


Pro Gln Pro Ala Ala Ala Leu Arg Ala Ala Pro Pro Pro Ser Ser Ser 
145                 150                 155                 160 


Ser Ser Ser Ser Ser Ser Ser Ala Ser Leu Ser Phe Ser Pro Gly Ser 
                165                 170                 175     


Gln Phe Ser Leu Ser Tyr Glu Gly Phe Ser Leu Leu Pro Gly Ser Leu 
            180                 185                 190         


Tyr Tyr Trp Gln Leu Pro Arg Ala Phe Leu Gly Asp Lys Val Ala Ala 
        195                 200                 205             


Tyr Gly Gly Lys Leu Arg Tyr Thr Leu Ser Tyr Thr Ala Gly Pro Gln 
    210                 215                 220                 


Gly Ser Pro Leu Ser Asp Pro Asp Val Gln Ile Thr 
225                 230                 235     


<210>  6611
<211>  4391
<212>  PRT
<213>  Homo Sapiens

<400>  6611

Met Gly Trp Arg Ala Ala Gly Ala Leu Leu Leu Ala Leu Leu Leu His 
1               5                   10                  15      


Gly Arg Leu Leu Ala Val Thr His Gly Leu Arg Ala Tyr Asp Gly Leu 
            20                  25                  30          


Ser Leu Pro Glu Asp Ile Glu Thr Val Thr Ala Ser Gln Met Arg Trp 
        35                  40                  45              


Thr His Ser Tyr Leu Ser Asp Asp Glu Asp Met Leu Ala Asp Ser Ile 
    50                  55                  60                  


Ser Gly Asp Asp Leu Gly Ser Gly Asp Leu Gly Ser Gly Asp Phe Gln 
65                  70                  75                  80  


Met Val Tyr Phe Arg Ala Leu Val Asn Phe Thr Arg Ser Ile Glu Tyr 
                85                  90                  95      


Ser Pro Gln Leu Glu Asp Ala Gly Ser Arg Glu Phe Arg Glu Val Ser 
            100                 105                 110         


Glu Ala Val Val Asp Thr Leu Glu Ser Glu Tyr Leu Lys Ile Pro Gly 
        115                 120                 125             


Asp Gln Val Val Ser Val Val Phe Ile Lys Glu Leu Asp Gly Trp Val 
    130                 135                 140                 


Phe Val Glu Leu Asp Val Gly Ser Glu Gly Asn Ala Asp Gly Ala Gln 
145                 150                 155                 160 


Ile Gln Glu Met Leu Leu Arg Val Ile Ser Ser Gly Ser Val Ala Ser 
                165                 170                 175     


Tyr Val Thr Ser Pro Gln Gly Phe Gln Phe Arg Arg Leu Gly Thr Val 
            180                 185                 190         


Pro Gln Phe Pro Arg Ala Cys Thr Glu Ala Glu Phe Ala Cys His Ser 
        195                 200                 205             


Tyr Asn Glu Cys Val Ala Leu Glu Tyr Arg Cys Asp Arg Arg Pro Asp 
    210                 215                 220                 


Cys Arg Asp Met Ser Asp Glu Leu Asn Cys Glu Glu Pro Val Leu Gly 
225                 230                 235                 240 


Ile Ser Pro Thr Phe Ser Leu Leu Val Glu Thr Thr Ser Leu Pro Pro 
                245                 250                 255     


Arg Pro Glu Thr Thr Ile Met Arg Gln Pro Pro Val Thr His Ala Pro 
            260                 265                 270         


Gln Pro Leu Leu Pro Gly Ser Val Arg Pro Leu Pro Cys Gly Pro Gln 
        275                 280                 285             


Glu Ala Ala Cys Arg Asn Gly His Cys Ile Pro Arg Asp Tyr Leu Cys 
    290                 295                 300                 


Asp Gly Gln Glu Asp Cys Glu Asp Gly Ser Asp Glu Leu Asp Cys Gly 
305                 310                 315                 320 


Pro Pro Pro Pro Cys Glu Pro Asn Glu Phe Pro Cys Gly Asn Gly His 
                325                 330                 335     


Cys Ala Leu Lys Leu Trp Arg Cys Asp Gly Asp Phe Asp Cys Glu Asp 
            340                 345                 350         


Arg Thr Asp Glu Ala Asn Cys Pro Thr Lys Arg Pro Glu Glu Val Cys 
        355                 360                 365             


Gly Pro Thr Gln Phe Arg Cys Val Ser Thr Asn Met Cys Ile Pro Ala 
    370                 375                 380                 


Ser Phe His Cys Asp Glu Glu Ser Asp Cys Pro Asp Arg Ser Asp Glu 
385                 390                 395                 400 


Phe Gly Cys Met Pro Pro Gln Val Val Thr Pro Pro Arg Glu Ser Ile 
                405                 410                 415     


Gln Ala Ser Arg Gly Gln Thr Val Thr Phe Thr Cys Val Ala Ile Gly 
            420                 425                 430         


Val Pro Thr Pro Ile Ile Asn Trp Arg Leu Asn Trp Gly His Ile Pro 
        435                 440                 445             


Ser His Pro Arg Val Thr Val Thr Ser Glu Gly Gly Arg Gly Thr Leu 
    450                 455                 460                 


Ile Ile Arg Asp Val Lys Glu Ser Asp Gln Gly Ala Tyr Thr Cys Glu 
465                 470                 475                 480 


Ala Met Asn Ala Arg Gly Met Val Phe Gly Ile Pro Asp Gly Val Leu 
                485                 490                 495     


Glu Leu Val Pro Gln Arg Gly Pro Cys Pro Asp Gly His Phe Tyr Leu 
            500                 505                 510         


Glu His Ser Ala Ala Cys Leu Pro Cys Phe Cys Phe Gly Ile Thr Ser 
        515                 520                 525             


Val Cys Gln Ser Thr Arg Arg Phe Arg Asp Gln Ile Arg Leu Arg Phe 
    530                 535                 540                 


Asp Gln Pro Asp Asp Phe Lys Gly Val Asn Val Thr Met Pro Ala Gln 
545                 550                 555                 560 


Pro Gly Thr Pro Pro Leu Ser Ser Thr Gln Leu Gln Ile Asp Pro Ser 
                565                 570                 575     


Leu His Glu Phe Gln Leu Val Asp Leu Ser Arg Arg Phe Leu Val His 
            580                 585                 590         


Asp Ser Phe Trp Ala Leu Pro Glu Gln Phe Leu Gly Asn Lys Val Asp 
        595                 600                 605             


Ser Tyr Gly Gly Ser Leu Arg Tyr Asn Val Arg Tyr Glu Leu Ala Arg 
    610                 615                 620                 


Gly Met Leu Glu Pro Val Gln Arg Pro Asp Val Val Leu Met Gly Ala 
625                 630                 635                 640 


Gly Tyr Arg Leu Leu Ser Arg Gly His Thr Pro Thr Gln Pro Gly Ala 
                645                 650                 655     


Leu Asn Gln Arg Gln Val Gln Phe Ser Glu Glu His Trp Val His Glu 
            660                 665                 670         


Ser Gly Arg Pro Val Gln Arg Ala Glu Leu Leu Gln Val Leu Gln Ser 
        675                 680                 685             


Leu Glu Ala Val Leu Ile Gln Thr Val Tyr Asn Thr Lys Met Ala Ser 
    690                 695                 700                 


Val Gly Leu Ser Asp Ile Ala Met Asp Thr Thr Val Thr His Ala Thr 
705                 710                 715                 720 


Ser His Gly Arg Ala His Ser Val Glu Glu Cys Arg Cys Pro Ile Gly 
                725                 730                 735     


Tyr Ser Gly Leu Ser Cys Glu Ser Cys Asp Ala His Phe Thr Arg Val 
            740                 745                 750         


Pro Gly Gly Pro Tyr Leu Gly Thr Cys Ser Gly Cys Asn Cys Asn Gly 
        755                 760                 765             


His Ala Ser Ser Cys Asp Pro Val Tyr Gly His Cys Leu Asn Cys Gln 
    770                 775                 780                 


His Asn Thr Glu Gly Pro Gln Cys Asn Lys Cys Lys Ala Gly Phe Phe 
785                 790                 795                 800 


Gly Asp Ala Met Lys Ala Thr Ala Thr Ser Cys Arg Pro Cys Pro Cys 
                805                 810                 815     


Pro Tyr Ile Asp Ala Ser Arg Arg Phe Ser Asp Thr Cys Phe Leu Asp 
            820                 825                 830         


Thr Asp Gly Gln Ala Thr Cys Asp Ala Cys Ala Pro Gly Tyr Thr Gly 
        835                 840                 845             


Arg Arg Cys Glu Ser Cys Ala Pro Gly Tyr Glu Gly Asn Pro Ile Gln 
    850                 855                 860                 


Pro Gly Gly Lys Cys Arg Pro Val Asn Gln Glu Ile Val Arg Cys Asp 
865                 870                 875                 880 


Glu Arg Gly Ser Met Gly Thr Ser Gly Glu Ala Cys Arg Cys Lys Asn 
                885                 890                 895     


Asn Val Val Gly Arg Leu Cys Asn Glu Cys Ala Asp Gly Ser Phe His 
            900                 905                 910         


Leu Ser Thr Arg Asn Pro Asp Gly Cys Leu Lys Cys Phe Cys Met Gly 
        915                 920                 925             


Val Ser Arg His Cys Thr Ser Ser Ser Trp Ser Arg Ala Gln Leu His 
    930                 935                 940                 


Gly Ala Ser Glu Glu Pro Gly His Phe Ser Leu Thr Asn Ala Ala Ser 
945                 950                 955                 960 


Thr His Thr Thr Asn Glu Gly Ile Phe Ser Pro Thr Pro Gly Glu Leu 
                965                 970                 975     


Gly Phe Ser Ser Phe His Arg Leu Leu Ser Gly Pro Tyr Phe Trp Ser 
            980                 985                 990         


Leu Pro Ser Arg Phe Leu Gly Asp  Lys Val Thr Ser Tyr  Gly Gly Glu 
        995                 1000                 1005             


Leu Arg  Phe Thr Val Thr Gln  Arg Ser Gln Pro Gly  Ser Thr Pro 
    1010                 1015                 1020             


Leu His  Gly Gln Pro Leu Val  Val Leu Gln Gly Asn  Asn Ile Ile 
    1025                 1030                 1035             


Leu Glu  His His Val Ala Gln  Glu Pro Ser Pro Gly  Gln Pro Ser 
    1040                 1045                 1050             


Thr Phe  Ile Val Pro Phe Arg  Glu Gln Ala Trp Gln  Arg Pro Asp 
    1055                 1060                 1065             


Gly Gln  Pro Ala Thr Arg Glu  His Leu Leu Met Ala  Leu Ala Gly 
    1070                 1075                 1080             


Ile Asp  Thr Leu Leu Ile Arg  Ala Ser Tyr Ala Gln  Gln Pro Ala 
    1085                 1090                 1095             


Glu Ser  Arg Val Ser Gly Ile  Ser Met Asp Val Ala  Val Pro Glu 
    1100                 1105                 1110             


Glu Thr  Gly Gln Asp Pro Ala  Leu Glu Val Glu Gln  Cys Ser Cys 
    1115                 1120                 1125             


Pro Pro  Gly Tyr Arg Gly Pro  Ser Cys Gln Asp Cys  Asp Thr Gly 
    1130                 1135                 1140             


Tyr Thr  Arg Thr Pro Ser Gly  Leu Tyr Leu Gly Thr  Cys Glu Arg 
    1145                 1150                 1155             


Cys Ser  Cys His Gly His Ser  Glu Ala Cys Glu Pro  Glu Thr Gly 
    1160                 1165                 1170             


Ala Cys  Gln Gly Cys Gln His  His Thr Glu Gly Pro  Arg Cys Glu 
    1175                 1180                 1185             


Gln Cys  Gln Pro Gly Tyr Tyr  Gly Asp Ala Gln Arg  Gly Thr Pro 
    1190                 1195                 1200             


Gln Asp  Cys Gln Leu Cys Pro  Cys Tyr Gly Asp Pro  Ala Ala Gly 
    1205                 1210                 1215             


Gln Ala  Ala His Thr Cys Phe  Leu Asp Thr Asp Gly  His Pro Thr 
    1220                 1225                 1230             


Cys Asp  Ala Cys Ser Pro Gly  His Ser Gly Arg His  Cys Glu Arg 
    1235                 1240                 1245             


Cys Ala  Pro Gly Tyr Tyr Gly  Asn Pro Ser Gln Gly  Gln Pro Cys 
    1250                 1255                 1260             


Gln Arg  Asp Ser Gln Val Pro  Gly Pro Ile Gly Cys  Asn Cys Asp 
    1265                 1270                 1275             


Pro Gln  Gly Ser Val Ser Ser  Gln Cys Asp Ala Ala  Gly Gln Cys 
    1280                 1285                 1290             


Gln Cys  Lys Ala Gln Val Glu  Gly Leu Thr Cys Ser  His Cys Arg 
    1295                 1300                 1305             


Pro His  His Phe His Leu Ser  Ala Ser Asn Pro Asp  Gly Cys Leu 
    1310                 1315                 1320             


Pro Cys  Phe Cys Met Gly Ile  Thr Gln Gln Cys Ala  Ser Ser Ala 
    1325                 1330                 1335             


Tyr Thr  Arg His Leu Ile Ser  Thr His Phe Ala Pro  Gly Asp Phe 
    1340                 1345                 1350             


Gln Gly  Phe Ala Leu Val Asn  Pro Gln Arg Asn Ser  Arg Leu Thr 
    1355                 1360                 1365             


Gly Glu  Phe Thr Val Glu Pro  Val Pro Glu Gly Ala  Gln Leu Ser 
    1370                 1375                 1380             


Phe Gly  Asn Phe Ala Gln Leu  Gly His Glu Ser Phe  Tyr Trp Gln 
    1385                 1390                 1395             


Leu Pro  Glu Thr Tyr Gln Gly  Asp Lys Val Ala Ala  Tyr Gly Gly 
    1400                 1405                 1410             


Lys Leu  Arg Tyr Thr Leu Ser  Tyr Thr Ala Gly Pro  Gln Gly Ser 
    1415                 1420                 1425             


Pro Leu  Ser Asp Pro Asp Val  Gln Ile Thr Gly Asn  Asn Ile Met 
    1430                 1435                 1440             


Leu Val  Ala Ser Gln Pro Ala  Leu Gln Gly Pro Glu  Arg Arg Ser 
    1445                 1450                 1455             


Tyr Glu  Ile Met Phe Arg Glu  Glu Phe Trp Arg Arg  Pro Asp Gly 
    1460                 1465                 1470             


Gln Pro  Ala Thr Arg Glu His  Leu Leu Met Ala Leu  Ala Asp Leu 
    1475                 1480                 1485             


Asp Glu  Leu Leu Ile Arg Ala  Thr Phe Ser Ser Val  Pro Leu Ala 
    1490                 1495                 1500             


Ala Ser  Ile Ser Ala Val Ser  Leu Glu Val Ala Gln  Pro Gly Pro 
    1505                 1510                 1515             


Ser Asn  Arg Pro Arg Ala Leu  Glu Val Glu Glu Cys  Arg Cys Pro 
    1520                 1525                 1530             


Pro Gly  Tyr Ile Gly Leu Ser  Cys Gln Asp Cys Ala  Pro Gly Tyr 
    1535                 1540                 1545             


Thr Arg  Thr Gly Ser Gly Leu  Tyr Leu Gly His Cys  Glu Leu Cys 
    1550                 1555                 1560             


Glu Cys  Asn Gly His Ser Asp  Leu Cys His Pro Glu  Thr Gly Ala 
    1565                 1570                 1575             


Cys Ser  Gln Cys Gln His Asn  Ala Ala Gly Glu Phe  Cys Glu Leu 
    1580                 1585                 1590             


Cys Ala  Pro Gly Tyr Tyr Gly  Asp Ala Thr Ala Gly  Thr Pro Glu 
    1595                 1600                 1605             


Asp Cys  Gln Pro Cys Ala Cys  Pro Leu Thr Asn Pro  Glu Asn Met 
    1610                 1615                 1620             


Phe Ser  Arg Thr Cys Glu Ser  Leu Gly Ala Gly Gly  Tyr Arg Cys 
    1625                 1630                 1635             


Thr Ala  Cys Glu Pro Gly Tyr  Thr Gly Gln Tyr Cys  Glu Gln Cys 
    1640                 1645                 1650             


Gly Pro  Gly Tyr Val Gly Asn  Pro Ser Val Gln Gly  Gly Gln Cys 
    1655                 1660                 1665             


Leu Pro  Glu Thr Asn Gln Ala  Pro Leu Val Val Glu  Val His Pro 
    1670                 1675                 1680             


Ala Arg  Ser Ile Val Pro Gln  Gly Gly Ser His Ser  Leu Arg Cys 
    1685                 1690                 1695             


Gln Val  Ser Gly Ser Pro Pro  His Tyr Phe Tyr Trp  Ser Arg Glu 
    1700                 1705                 1710             


Asp Gly  Arg Pro Val Pro Ser  Gly Thr Gln Gln Arg  His Gln Gly 
    1715                 1720                 1725             


Ser Glu  Leu His Phe Pro Ser  Val Gln Pro Ser Asp  Ala Gly Val 
    1730                 1735                 1740             


Tyr Ile  Cys Thr Cys Arg Asn  Leu His Gln Ser Asn  Thr Ser Arg 
    1745                 1750                 1755             


Ala Glu  Leu Leu Val Thr Glu  Ala Pro Ser Lys Pro  Ile Thr Val 
    1760                 1765                 1770             


Thr Val  Glu Glu Gln Arg Ser  Gln Ser Val Arg Pro  Gly Ala Asp 
    1775                 1780                 1785             


Val Thr  Phe Ile Cys Thr Ala  Lys Ser Lys Ser Pro  Ala Tyr Thr 
    1790                 1795                 1800             


Leu Val  Trp Thr Arg Leu His  Asn Gly Lys Leu Pro  Thr Arg Ala 
    1805                 1810                 1815             


Met Asp  Phe Asn Gly Ile Leu  Thr Ile Arg Asn Val  Gln Leu Ser 
    1820                 1825                 1830             


Asp Ala  Gly Thr Tyr Val Cys  Thr Gly Ser Asn Met  Phe Ala Met 
    1835                 1840                 1845             


Asp Gln  Gly Thr Ala Thr Leu  His Val Gln Ala Ser  Gly Thr Leu 
    1850                 1855                 1860             


Ser Ala  Pro Val Val Ser Ile  His Pro Pro Gln Leu  Thr Val Gln 
    1865                 1870                 1875             


Pro Gly  Gln Leu Ala Glu Phe  Arg Cys Ser Ala Thr  Gly Ser Pro 
    1880                 1885                 1890             


Thr Pro  Thr Leu Glu Trp Thr  Gly Gly Pro Gly Gly  Gln Leu Pro 
    1895                 1900                 1905             


Ala Lys  Ala Gln Ile His Gly  Gly Ile Leu Arg Leu  Pro Ala Val 
    1910                 1915                 1920             


Glu Pro  Thr Asp Gln Ala Gln  Tyr Leu Cys Arg Ala  His Ser Ser 
    1925                 1930                 1935             


Ala Gly  Gln Gln Val Ala Arg  Ala Val Leu His Val  His Gly Gly 
    1940                 1945                 1950             


Gly Gly  Pro Arg Val Gln Val  Ser Pro Glu Arg Thr  Gln Val His 
    1955                 1960                 1965             


Ala Gly  Arg Thr Val Arg Leu  Tyr Cys Arg Ala Ala  Gly Val Pro 
    1970                 1975                 1980             


Ser Ala  Thr Ile Thr Trp Arg  Lys Glu Gly Gly Ser  Leu Pro Pro 
    1985                 1990                 1995             


Gln Ala  Arg Ser Glu Arg Thr  Asp Ile Ala Thr Leu  Leu Ile Pro 
    2000                 2005                 2010             


Ala Ile  Thr Thr Ala Asp Ala  Gly Phe Tyr Leu Cys  Val Ala Thr 
    2015                 2020                 2025             


Ser Pro  Ala Gly Thr Ala Gln  Ala Arg Ile Gln Val  Val Val Leu 
    2030                 2035                 2040             


Ser Ala  Ser Asp Ala Ser Pro  Pro Pro Val Lys Ile  Glu Ser Ser 
    2045                 2050                 2055             


Ser Pro  Ser Val Thr Glu Gly  Gln Thr Leu Asp Leu  Asn Cys Val 
    2060                 2065                 2070             


Val Ala  Gly Ser Ala His Ala  Gln Val Thr Trp Tyr  Arg Arg Gly 
    2075                 2080                 2085             


Gly Ser  Leu Pro Pro His Thr  Gln Val His Gly Ser  Arg Leu Arg 
    2090                 2095                 2100             


Leu Pro  Gln Val Ser Pro Ala  Asp Ser Gly Glu Tyr  Val Cys Arg 
    2105                 2110                 2115             


Val Glu  Asn Gly Ser Gly Pro  Lys Glu Ala Ser Ile  Thr Val Ser 
    2120                 2125                 2130             


Val Leu  His Gly Thr His Ser  Gly Pro Ser Tyr Thr  Pro Val Pro 
    2135                 2140                 2145             


Gly Ser  Thr Arg Pro Ile Arg  Ile Glu Pro Ser Ser  Ser His Val 
    2150                 2155                 2160             


Ala Glu  Gly Gln Thr Leu Asp  Leu Asn Cys Val Val  Pro Gly Gln 
    2165                 2170                 2175             


Ala His  Ala Gln Val Thr Trp  His Lys Arg Gly Gly  Ser Leu Pro 
    2180                 2185                 2190             


Ala Arg  His Gln Thr His Gly  Ser Leu Leu Arg Leu  His Gln Val 
    2195                 2200                 2205             


Thr Pro  Ala Asp Ser Gly Glu  Tyr Val Cys His Val  Val Gly Thr 
    2210                 2215                 2220             


Ser Gly  Pro Leu Glu Ala Ser  Val Leu Val Thr Ile  Glu Ala Ser 
    2225                 2230                 2235             


Val Ile  Pro Gly Pro Ile Pro  Pro Val Arg Ile Glu  Ser Ser Ser 
    2240                 2245                 2250             


Ser Thr  Val Ala Glu Gly Gln  Thr Leu Asp Leu Ser  Cys Val Val 
    2255                 2260                 2265             


Ala Gly  Gln Ala His Ala Gln  Val Thr Trp Tyr Lys  Arg Gly Gly 
    2270                 2275                 2280             


Ser Leu  Pro Ala Arg His Gln  Val Arg Gly Ser Arg  Leu Tyr Ile 
    2285                 2290                 2295             


Phe Gln  Ala Ser Pro Ala Asp  Ala Gly Gln Tyr Val  Cys Arg Ala 
    2300                 2305                 2310             


Ser Asn  Gly Met Glu Ala Ser  Ile Thr Val Thr Val  Thr Gly Thr 
    2315                 2320                 2325             


Gln Gly  Ala Asn Leu Ala Tyr  Pro Ala Gly Ser Thr  Gln Pro Ile 
    2330                 2335                 2340             


Arg Ile  Glu Pro Ser Ser Ser  Gln Val Ala Glu Gly  Gln Thr Leu 
    2345                 2350                 2355             


Asp Leu  Asn Cys Val Val Pro  Gly Gln Ser His Ala  Gln Val Thr 
    2360                 2365                 2370             


Trp His  Lys Arg Gly Gly Ser  Leu Pro Val Arg His  Gln Thr His 
    2375                 2380                 2385             


Gly Ser  Leu Leu Arg Leu Tyr  Gln Ala Ser Pro Ala  Asp Ser Gly 
    2390                 2395                 2400             


Glu Tyr  Val Cys Arg Val Leu  Gly Ser Ser Val Pro  Leu Glu Ala 
    2405                 2410                 2415             


Ser Val  Leu Val Thr Ile Glu  Pro Ala Gly Ser Val  Pro Ala Leu 
    2420                 2425                 2430             


Gly Val  Thr Pro Thr Val Arg  Ile Glu Ser Ser Ser  Ser Gln Val 
    2435                 2440                 2445             


Ala Glu  Gly Gln Thr Leu Asp  Leu Asn Cys Leu Val  Ala Gly Gln 
    2450                 2455                 2460             


Ala His  Ala Gln Val Thr Trp  His Lys Arg Gly Gly  Ser Leu Pro 
    2465                 2470                 2475             


Ala Arg  His Gln Val His Gly  Ser Arg Leu Arg Leu  Leu Gln Val 
    2480                 2485                 2490             


Thr Pro  Ala Asp Ser Gly Glu  Tyr Val Cys Arg Val  Val Gly Ser 
    2495                 2500                 2505             


Ser Gly  Thr Gln Glu Ala Ser  Val Leu Val Thr Ile  Gln Gln Arg 
    2510                 2515                 2520             


Leu Ser  Gly Ser His Ser Gln  Gly Val Ala Tyr Pro  Val Arg Ile 
    2525                 2530                 2535             


Glu Ser  Ser Ser Ala Ser Leu  Ala Asn Gly His Thr  Leu Asp Leu 
    2540                 2545                 2550             


Asn Cys  Leu Val Ala Ser Gln  Ala Pro His Thr Ile  Thr Trp Tyr 
    2555                 2560                 2565             


Lys Arg  Gly Gly Ser Leu Pro  Ser Arg His Gln Ile  Val Gly Ser 
    2570                 2575                 2580             


Arg Leu  Arg Ile Pro Gln Val  Thr Pro Ala Asp Ser  Gly Glu Tyr 
    2585                 2590                 2595             


Val Cys  His Val Ser Asn Gly  Ala Gly Ser Arg Glu  Thr Ser Leu 
    2600                 2605                 2610             


Ile Val  Thr Ile Gln Gly Ser  Gly Ser Ser His Val  Pro Ser Val 
    2615                 2620                 2625             


Ser Pro  Pro Ile Arg Ile Glu  Ser Ser Ser Pro Thr  Val Val Glu 
    2630                 2635                 2640             


Gly Gln  Thr Leu Asp Leu Asn  Cys Val Val Ala Arg  Gln Pro Gln 
    2645                 2650                 2655             


Ala Ile  Ile Thr Trp Tyr Lys  Arg Gly Gly Ser Leu  Pro Ser Arg 
    2660                 2665                 2670             


His Gln  Thr His Gly Ser His  Leu Arg Leu His Gln  Met Ser Val 
    2675                 2680                 2685             


Ala Asp  Ser Gly Glu Tyr Val  Cys Arg Ala Asn Asn  Asn Ile Asp 
    2690                 2695                 2700             


Ala Leu  Glu Ala Ser Ile Val  Ile Ser Val Ser Pro  Ser Ala Gly 
    2705                 2710                 2715             


Ser Pro  Ser Ala Pro Gly Ser  Ser Met Pro Ile Arg  Ile Glu Ser 
    2720                 2725                 2730             


Ser Ser  Ser His Val Ala Glu  Gly Glu Thr Leu Asp  Leu Asn Cys 
    2735                 2740                 2745             


Val Val  Pro Gly Gln Ala His  Ala Gln Val Thr Trp  His Lys Arg 
    2750                 2755                 2760             


Gly Gly  Ser Leu Pro Ser His  His Gln Thr Arg Gly  Ser Arg Leu 
    2765                 2770                 2775             


Arg Leu  His His Val Ser Pro  Ala Asp Ser Gly Glu  Tyr Val Cys 
    2780                 2785                 2790             


Arg Val  Met Gly Ser Ser Gly  Pro Leu Glu Ala Ser  Val Leu Val 
    2795                 2800                 2805             


Thr Ile  Glu Ala Ser Gly Ser  Ser Ala Val His Val  Pro Ala Pro 
    2810                 2815                 2820             


Gly Gly  Ala Pro Pro Ile Arg  Ile Glu Pro Ser Ser  Ser Arg Val 
    2825                 2830                 2835             


Ala Glu  Gly Gln Thr Leu Asp  Leu Lys Cys Val Val  Pro Gly Gln 
    2840                 2845                 2850             


Ala His  Ala Gln Val Thr Trp  His Lys Arg Gly Gly  Asn Leu Pro 
    2855                 2860                 2865             


Ala Arg  His Gln Val His Gly  Pro Leu Leu Arg Leu  Asn Gln Val 
    2870                 2875                 2880             


Ser Pro  Ala Asp Ser Gly Glu  Tyr Ser Cys Gln Val  Thr Gly Ser 
    2885                 2890                 2895             


Ser Gly  Thr Leu Glu Ala Ser  Val Leu Val Thr Ile  Glu Pro Ser 
    2900                 2905                 2910             


Ser Pro  Gly Pro Ile Pro Ala  Pro Gly Leu Ala Gln  Pro Ile Tyr 
    2915                 2920                 2925             


Ile Glu  Ala Ser Ser Ser His  Val Thr Glu Gly Gln  Thr Leu Asp 
    2930                 2935                 2940             


Leu Asn  Cys Val Val Pro Gly  Gln Ala His Ala Gln  Val Thr Trp 
    2945                 2950                 2955             


Tyr Lys  Arg Gly Gly Ser Leu  Pro Ala Arg His Gln  Thr His Gly 
    2960                 2965                 2970             


Ser Gln  Leu Arg Leu His Leu  Val Ser Pro Ala Asp  Ser Gly Glu 
    2975                 2980                 2985             


Tyr Val  Cys Arg Ala Ala Ser  Gly Pro Gly Pro Glu  Gln Glu Ala 
    2990                 2995                 3000             


Ser Phe  Thr Val Thr Val Pro  Pro Ser Glu Gly Ser  Ser Tyr Arg 
    3005                 3010                 3015             


Leu Arg  Ser Pro Val Ile Ser  Ile Asp Pro Pro Ser  Ser Thr Val 
    3020                 3025                 3030             


Gln Gln  Gly Gln Asp Ala Ser  Phe Lys Cys Leu Ile  His Asp Gly 
    3035                 3040                 3045             


Ala Ala  Pro Ile Ser Leu Glu  Trp Lys Thr Arg Asn  Gln Glu Leu 
    3050                 3055                 3060             


Glu Asp  Asn Val His Ile Ser  Pro Asn Gly Ser Ile  Ile Thr Ile 
    3065                 3070                 3075             


Val Gly  Thr Arg Pro Ser Asn  His Gly Thr Tyr Arg  Cys Val Ala 
    3080                 3085                 3090             


Ser Asn  Ala Tyr Gly Val Ala  Gln Ser Val Val Asn  Leu Ser Val 
    3095                 3100                 3105             


His Gly  Pro Pro Thr Val Ser  Val Leu Pro Glu Gly  Pro Val Trp 
    3110                 3115                 3120             


Val Lys  Val Gly Lys Ala Val  Thr Leu Glu Cys Val  Ser Ala Gly 
    3125                 3130                 3135             


Glu Pro  Arg Ser Ser Ala Arg  Trp Thr Arg Ile Ser  Ser Thr Pro 
    3140                 3145                 3150             


Ala Lys  Leu Glu Gln Arg Thr  Tyr Gly Leu Met Asp  Ser His Ala 
    3155                 3160                 3165             


Val Leu  Gln Ile Ser Ser Ala  Lys Pro Ser Asp Ala  Gly Thr Tyr 
    3170                 3175                 3180             


Val Cys  Leu Ala Gln Asn Ala  Leu Gly Thr Ala Gln  Lys Gln Val 
    3185                 3190                 3195             


Glu Val  Ile Val Asp Thr Gly  Ala Met Ala Pro Gly  Ala Pro Gln 
    3200                 3205                 3210             


Val Gln  Ala Glu Glu Ala Glu  Leu Thr Val Glu Ala  Gly His Thr 
    3215                 3220                 3225             


Ala Thr  Leu Arg Cys Ser Ala  Thr Gly Ser Pro Ala  Pro Thr Ile 
    3230                 3235                 3240             


His Trp  Ser Lys Leu Arg Ser  Pro Leu Pro Trp Gln  His Arg Leu 
    3245                 3250                 3255             


Glu Gly  Asp Thr Leu Ile Ile  Pro Arg Val Ala Gln  Gln Asp Ser 
    3260                 3265                 3270             


Gly Gln  Tyr Ile Cys Asn Ala  Thr Ser Pro Ala Gly  His Ala Glu 
    3275                 3280                 3285             


Ala Thr  Ile Ile Leu His Val  Glu Ser Pro Pro Tyr  Ala Thr Thr 
    3290                 3295                 3300             


Val Pro  Glu His Ala Ser Val  Gln Ala Gly Glu Thr  Val Gln Leu 
    3305                 3310                 3315             


Gln Cys  Leu Ala His Gly Thr  Pro Pro Leu Thr Phe  Gln Trp Ser 
    3320                 3325                 3330             


Arg Val  Gly Ser Ser Leu Pro  Gly Arg Ala Thr Ala  Arg Asn Glu 
    3335                 3340                 3345             


Leu Leu  His Phe Glu Arg Ala  Ala Pro Glu Asp Ser  Gly Arg Tyr 
    3350                 3355                 3360             


Arg Cys  Arg Val Thr Asn Lys  Val Gly Ser Ala Glu  Ala Phe Ala 
    3365                 3370                 3375             


Gln Leu  Leu Val Gln Gly Pro  Pro Gly Ser Leu Pro  Ala Thr Ser 
    3380                 3385                 3390             


Ile Pro  Ala Gly Ser Thr Pro  Thr Val Gln Val Thr  Pro Gln Leu 
    3395                 3400                 3405             


Glu Thr  Lys Ser Ile Gly Ala  Ser Val Glu Phe His  Cys Ala Val 
    3410                 3415                 3420             


Pro Ser  Asp Arg Gly Thr Gln  Leu Arg Trp Phe Lys  Glu Gly Gly 
    3425                 3430                 3435             


Gln Leu  Pro Pro Gly His Ser  Val Gln Asp Gly Val  Leu Arg Ile 
    3440                 3445                 3450             


Gln Asn  Leu Asp Gln Ser Cys  Gln Gly Thr Tyr Ile  Cys Gln Ala 
    3455                 3460                 3465             


His Gly  Pro Trp Gly Lys Ala  Gln Ala Ser Ala Gln  Leu Val Ile 
    3470                 3475                 3480             


Gln Ala  Leu Pro Ser Val Leu  Ile Asn Ile Arg Thr  Ser Val Gln 
    3485                 3490                 3495             


Thr Val  Val Val Gly His Ala  Val Glu Phe Glu Cys  Leu Ala Leu 
    3500                 3505                 3510             


Gly Asp  Pro Lys Pro Gln Val  Thr Trp Ser Lys Val  Gly Gly His 
    3515                 3520                 3525             


Leu Arg  Pro Gly Ile Val Gln  Ser Gly Gly Val Val  Arg Ile Ala 
    3530                 3535                 3540             


His Val  Glu Leu Ala Asp Ala  Gly Gln Tyr Arg Cys  Thr Ala Thr 
    3545                 3550                 3555             


Asn Ala  Ala Gly Thr Thr Gln  Ser His Val Leu Leu  Leu Val Gln 
    3560                 3565                 3570             


Ala Leu  Pro Gln Ile Ser Met  Pro Gln Glu Val Arg  Val Pro Ala 
    3575                 3580                 3585             


Gly Ser  Ala Ala Val Phe Pro  Cys Ile Ala Ser Gly  Tyr Pro Thr 
    3590                 3595                 3600             


Pro Asp  Ile Ser Trp Ser Lys  Leu Asp Gly Ser Leu  Pro Pro Asp 
    3605                 3610                 3615             


Ser Arg  Leu Glu Asn Asn Met  Leu Met Leu Pro Ser  Val Arg Pro 
    3620                 3625                 3630             


Gln Asp  Ala Gly Thr Tyr Val  Cys Thr Ala Thr Asn  Arg Gln Gly 
    3635                 3640                 3645             


Lys Val  Lys Ala Phe Ala His  Leu Gln Val Pro Glu  Arg Val Val 
    3650                 3655                 3660             


Pro Tyr  Phe Thr Gln Thr Pro  Tyr Ser Phe Leu Pro  Leu Pro Thr 
    3665                 3670                 3675             


Ile Lys  Asp Ala Tyr Arg Lys  Phe Glu Ile Lys Ile  Thr Phe Arg 
    3680                 3685                 3690             


Pro Asp  Ser Ala Asp Gly Met  Leu Leu Tyr Asn Gly  Gln Lys Arg 
    3695                 3700                 3705             


Val Pro  Gly Ser Pro Thr Asn  Leu Ala Asn Arg Gln  Pro Asp Phe 
    3710                 3715                 3720             


Ile Ser  Phe Gly Leu Val Gly  Gly Arg Pro Glu Phe  Arg Phe Asp 
    3725                 3730                 3735             


Ala Gly  Ser Gly Met Ala Thr  Ile Arg His Pro Thr  Pro Leu Ala 
    3740                 3745                 3750             


Leu Gly  His Phe His Thr Val  Thr Leu Leu Arg Ser  Leu Thr Gln 
    3755                 3760                 3765             


Gly Ser  Leu Ile Val Gly Asp  Leu Ala Pro Val Asn  Gly Thr Ser 
    3770                 3775                 3780             


Gln Gly  Lys Phe Gln Gly Leu  Asp Leu Asn Glu Glu  Leu Tyr Leu 
    3785                 3790                 3795             


Gly Gly  Tyr Pro Asp Tyr Gly  Ala Ile Pro Lys Ala  Gly Leu Ser 
    3800                 3805                 3810             


Ser Gly  Phe Ile Gly Cys Val  Arg Glu Leu Arg Ile  Gln Gly Glu 
    3815                 3820                 3825             


Glu Ile  Val Phe His Asp Leu  Asn Leu Thr Ala His  Gly Ile Ser 
    3830                 3835                 3840             


His Cys  Pro Thr Cys Arg Asp  Arg Pro Cys Gln Asn  Gly Gly Gln 
    3845                 3850                 3855             


Cys His  Asp Ser Glu Ser Ser  Ser Tyr Val Cys Val  Cys Pro Ala 
    3860                 3865                 3870             


Gly Phe  Thr Gly Ser Arg Cys  Glu His Ser Gln Ala  Leu His Cys 
    3875                 3880                 3885             


His Pro  Glu Ala Cys Gly Pro  Asp Ala Thr Cys Val  Asn Arg Pro 
    3890                 3895                 3900             


Asp Gly  Arg Gly Tyr Thr Cys  Arg Cys His Leu Gly  Arg Ser Gly 
    3905                 3910                 3915             


Leu Arg  Cys Glu Glu Gly Val  Thr Val Thr Thr Pro  Ser Leu Ser 
    3920                 3925                 3930             


Gly Ala  Gly Ser Tyr Leu Ala  Leu Pro Ala Leu Thr  Asn Thr His 
    3935                 3940                 3945             


His Glu  Leu Arg Leu Asp Val  Glu Phe Lys Pro Leu  Ala Pro Asp 
    3950                 3955                 3960             


Gly Val  Leu Leu Phe Ser Gly  Gly Lys Ser Gly Pro  Val Glu Asp 
    3965                 3970                 3975             


Phe Val  Ser Leu Ala Met Val  Gly Gly His Leu Glu  Phe Arg Tyr 
    3980                 3985                 3990             


Glu Leu  Gly Ser Gly Leu Ala  Val Leu Arg Ser Ala  Glu Pro Leu 
    3995                 4000                 4005             


Ala Leu  Gly Arg Trp His Arg  Val Ser Ala Glu Arg  Leu Asn Lys 
    4010                 4015                 4020             


Asp Gly  Ser Leu Arg Val Asn  Gly Gly Arg Pro Val  Leu Arg Ser 
    4025                 4030                 4035             


Ser Pro  Gly Lys Ser Gln Gly  Leu Asn Leu His Thr  Leu Leu Tyr 
    4040                 4045                 4050             


Leu Gly  Gly Val Glu Pro Ser  Val Pro Leu Ser Pro  Ala Thr Asn 
    4055                 4060                 4065             


Met Ser  Ala His Phe Arg Gly  Cys Val Gly Glu Val  Ser Val Asn 
    4070                 4075                 4080             


Gly Lys  Arg Leu Asp Leu Thr  Tyr Ser Phe Leu Gly  Ser Gln Gly 
    4085                 4090                 4095             


Ile Gly  Gln Cys Tyr Asp Ser  Ser Pro Cys Glu Arg  Gln Pro Cys 
    4100                 4105                 4110             


Gln His  Gly Ala Thr Cys Met  Pro Ala Gly Glu Tyr  Glu Phe Gln 
    4115                 4120                 4125             


Cys Leu  Cys Arg Asp Gly Phe  Lys Gly Asp Leu Cys  Glu His Glu 
    4130                 4135                 4140             


Glu Asn  Pro Cys Gln Leu Arg  Glu Pro Cys Leu His  Gly Gly Thr 
    4145                 4150                 4155             


Cys Gln  Gly Thr Arg Cys Leu  Cys Leu Pro Gly Phe  Ser Gly Pro 
    4160                 4165                 4170             


Arg Cys  Gln Gln Gly Ser Gly  His Gly Ile Ala Glu  Ser Asp Trp 
    4175                 4180                 4185             


His Leu  Glu Gly Ser Gly Gly  Asn Asp Ala Pro Gly  Gln Tyr Gly 
    4190                 4195                 4200             


Ala Tyr  Phe His Asp Asp Gly  Phe Leu Ala Phe Pro  Gly His Val 
    4205                 4210                 4215             


Phe Ser  Arg Ser Leu Pro Glu  Val Pro Glu Thr Ile  Glu Leu Glu 
    4220                 4225                 4230             


Val Arg  Thr Ser Thr Ala Ser  Gly Leu Leu Leu Trp  Gln Gly Val 
    4235                 4240                 4245             


Glu Val  Gly Glu Ala Gly Gln  Gly Lys Asp Phe Ile  Ser Leu Gly 
    4250                 4255                 4260             


Leu Gln  Asp Gly His Leu Val  Phe Arg Tyr Gln Leu  Gly Ser Gly 
    4265                 4270                 4275             


Glu Ala  Arg Leu Val Ser Glu  Asp Pro Ile Asn Asp  Gly Glu Trp 
    4280                 4285                 4290             


His Arg  Val Thr Ala Leu Arg  Glu Gly Arg Arg Gly  Ser Ile Gln 
    4295                 4300                 4305             


Val Asp  Gly Glu Glu Leu Val  Ser Gly Arg Ser Pro  Gly Pro Asn 
    4310                 4315                 4320             


Val Ala  Val Asn Ala Lys Gly  Ser Val Tyr Ile Gly  Gly Ala Pro 
    4325                 4330                 4335             


Asp Val  Ala Thr Leu Thr Gly  Gly Arg Phe Ser Ser  Gly Ile Thr 
    4340                 4345                 4350             


Gly Cys  Val Lys Asn Leu Val  Leu His Ser Ala Arg  Pro Gly Ala 
    4355                 4360                 4365             


Pro Pro  Pro Gln Pro Leu Asp  Leu Gln His Arg Ala  Gln Ala Gly 
    4370                 4375                 4380             


Ala Asn  Thr Arg Pro Cys Pro  Ser 
    4385                 4390     


<210>  6612
<211>  109
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6612

Xaa Gly Thr Pro Pro Leu Thr Phe Gln Trp Ser Arg Val Gly Ser Ser 
1               5                   10                  15      


Leu Pro Gly Arg Ala Thr Ala Arg Asn Glu Leu Leu His Phe Glu Arg 
            20                  25                  30          


Ala Ala Pro Glu Asp Ser Gly Arg Tyr Arg Cys Arg Val Thr Asn Lys 
        35                  40                  45              


Val Gly Ser Ala Glu Ala Phe Ala Gln Leu Leu Val Gln Glu Ser Arg 
    50                  55                  60                  


Thr Trp Thr Arg Ala Ala Lys Gly Arg Ile Tyr Ala Arg Pro Met Asp 
65                  70                  75                  80  


Leu Gly Gly Arg Pro Arg Pro Val Pro Ser Trp Leu Ser Lys Val Gly 
                85                  90                  95      


Gly Trp Leu Gln Ala Ser Ala Lys Ser Arg Glu Gln Arg 
            100                 105                 


<210>  6613
<211>  307
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6613

Xaa Asn Met Leu Met Leu Pro Ser Val Arg Pro Gln Asp Ala Gly Thr 
1               5                   10                  15      


Tyr Val Cys Thr Ala Thr Asn Arg Gln Gly Lys Val Lys Ala Phe Ala 
            20                  25                  30          


His Leu Gln Val Pro Glu Arg Val Val Pro Tyr Phe Thr Gln Thr Pro 
        35                  40                  45              


Tyr Ser Phe Leu Pro Leu Pro Thr Ile Lys Asp Ala Tyr Arg Lys Phe 
    50                  55                  60                  


Glu Ile Lys Ile Thr Phe Arg Pro Asp Ser Ala Asp Gly Leu Leu Leu 
65                  70                  75                  80  


Tyr Ser Gly Met Leu Leu Tyr Asn Gly Gln Lys Arg Val Pro Gly Ser 
                85                  90                  95      


Pro Thr Asn Leu Ala Asn Arg Gln Pro Asp Phe Ile Ser Phe Gly Leu 
            100                 105                 110         


Val Gly Gly Arg Pro Glu Phe Arg Phe Asp Ala Gly Ser Gly Met Ala 
        115                 120                 125             


Thr Ile Arg His Pro Thr Pro Leu Ala Leu Gly His Phe His Thr Val 
    130                 135                 140                 


Thr Leu Leu Arg Ser Leu Thr Gln Gly Ser Leu Ile Val Gly Asp Leu 
145                 150                 155                 160 


Ala Pro Val Asn Gly Thr Ser Gln Gly Lys Phe Gln Gly Leu Asp Leu 
                165                 170                 175     


Asn Glu Glu Leu Tyr Leu Gly Gly Tyr Pro Asp Tyr Gly Ala Ile Pro 
            180                 185                 190         


Lys Ala Gly Leu Ser Ser Gly Phe Ile Gly Cys Val Arg Glu Leu Arg 
        195                 200                 205             


Ile Gln Gly Glu Glu Ile Val Phe His Asp Leu Asn Leu Thr Ala His 
    210                 215                 220                 


Gly Ile Ser His Cys Pro Thr Cys Arg Asp Arg Pro Cys Gln Asn Gly 
225                 230                 235                 240 


Gly Gln Cys His Asp Ser Glu Ser Ser Ser Tyr Val Cys Val Cys Pro 
                245                 250                 255     


Ala Gly Phe Thr Gly Ser Arg Cys Glu His Ser Gln Ala Leu His Cys 
            260                 265                 270         


His Pro Glu Ala Cys Gly Pro Asp Ala Thr Cys Val Asn Arg Pro Asp 
        275                 280                 285             


Gly Arg Gly Tyr Thr Cys Arg Cys His Leu Gly Arg Ser Gly Leu Arg 
    290                 295                 300                 


Cys Glu Glu 
305         


<210>  6614
<211>  197
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6614

Xaa Thr Pro Ser Gly Leu Tyr Leu Gly Thr Cys Glu Arg Cys Ser Cys 
1               5                   10                  15      


His Gly His Ser Glu Ala Cys Glu Pro Glu Thr Gly Ala Cys Gln Gly 
            20                  25                  30          


Cys Gln His His Thr Glu Gly Pro Arg Cys Glu Gln Cys Gln Pro Gly 
        35                  40                  45              


Tyr Tyr Gly Asp Ala Gln Arg Gly Thr Pro Gln Asp Cys Gln Leu Cys 
    50                  55                  60                  


Pro Cys Tyr Gly Asp Pro Ala Ala Gly Gln Ala Ala His Thr Cys Phe 
65                  70                  75                  80  


Leu Asp Thr Asp Gly His Pro Thr Cys Asp Ala Cys Ser Pro Gly His 
                85                  90                  95      


Ser Gly Arg His Cys Glu Arg Cys Ala Pro Gly Tyr Tyr Gly Asn Pro 
            100                 105                 110         


Ser Gln Gly Gln Pro Cys Gln Arg Asp Ser Gln Val Pro Gly Pro Ile 
        115                 120                 125             


Gly Cys Asn Cys Asp Pro Gln Gly Ser Val Ser Ser Gln Cys Asp Ala 
    130                 135                 140                 


Ala Gly Gln Cys Gln Cys Lys Val Ser Pro Asn Pro Cys Pro Cys Gly 
145                 150                 155                 160 


Ala Cys Ser Ala Pro Leu Pro Arg Pro Cys Gly Glu Ile Arg Gln His 
                165                 170                 175     


Leu Val Glu Ala Glu Thr Trp Ala Trp Gly Ala Gly His Gly Gly Gln 
            180                 185                 190         


Gly Arg Gly Cys Pro 
        195         


<210>  6615
<211>  242
<212>  PRT
<213>  Homo Sapiens

<400>  6615

Met Ala Glu Thr Glu Ala Leu Ser Lys Leu Arg Glu Asp Phe Arg Met 
1               5                   10                  15      


Gln Asn Lys Ser Val Phe Ile Leu Gly Ala Ser Gly Glu Thr Gly Arg 
            20                  25                  30          


Val Leu Leu Lys Glu Ile Leu Glu Gln Gly Leu Phe Ser Lys Val Thr 
        35                  40                  45              


Leu Ile Gly Arg Arg Lys Leu Thr Phe Asp Glu Glu Ala Tyr Lys Asn 
    50                  55                  60                  


Val Asn Gln Glu Val Val Asp Phe Glu Lys Leu Asp Asp Tyr Ala Ser 
65                  70                  75                  80  


Ala Phe Gln Gly His Asp Val Gly Phe Cys Cys Leu Gly Thr Thr Arg 
                85                  90                  95      


Gly Lys Ala Gly Ala Glu Gly Phe Val Arg Val Asp Arg Asp Tyr Val 
            100                 105                 110         


Leu Lys Ser Ala Glu Leu Ala Lys Ala Gly Gly Cys Lys His Phe Asn 
        115                 120                 125             


Leu Leu Ser Ser Lys Gly Ala Asp Lys Ser Ser Asn Phe Leu Tyr Leu 
    130                 135                 140                 


Gln Val Lys Gly Glu Val Glu Ala Lys Val Glu Glu Leu Lys Phe Asp 
145                 150                 155                 160 


Arg Tyr Ser Val Phe Arg Pro Gly Val Leu Leu Cys Asp Arg Gln Glu 
                165                 170                 175     


Ser Arg Pro Gly Glu Trp Leu Val Arg Lys Phe Phe Gly Ser Leu Pro 
            180                 185                 190         


Asp Ser Trp Ala Ser Gly His Ser Val Pro Val Val Thr Val Val Arg 
        195                 200                 205             


Ala Met Leu Asn Asn Val Val Arg Pro Arg Asp Lys Gln Met Glu Leu 
    210                 215                 220                 


Leu Glu Asn Lys Ala Ile His Asp Leu Gly Lys Ala His Gly Ser Leu 
225                 230                 235                 240 


Lys Pro 
        


<210>  6616
<211>  242
<212>  PRT
<213>  Homo Sapiens

<400>  6616

Met Ala Glu Thr Glu Ala Leu Ser Lys Leu Arg Glu Asp Phe Arg Met 
1               5                   10                  15      


Gln Asn Lys Ser Val Phe Ile Leu Gly Ala Ser Gly Glu Thr Gly Arg 
            20                  25                  30          


Val Leu Leu Lys Glu Ile Leu Glu Gln Gly Leu Phe Ser Lys Val Thr 
        35                  40                  45              


Leu Ile Gly Arg Arg Lys Leu Thr Phe Asp Glu Glu Ala Tyr Lys Asn 
    50                  55                  60                  


Val Asn Gln Glu Val Val Asp Phe Glu Lys Leu Asp Asp Tyr Ala Ser 
65                  70                  75                  80  


Ala Phe Gln Gly His Asp Val Gly Phe Cys Cys Leu Gly Thr Thr Arg 
                85                  90                  95      


Gly Lys Ala Gly Ala Glu Gly Phe Val Arg Val Asp Arg Asp Tyr Val 
            100                 105                 110         


Leu Lys Ser Ala Glu Leu Ala Lys Ala Gly Gly Cys Lys His Phe Asn 
        115                 120                 125             


Leu Leu Ser Ser Lys Gly Ala Asp Lys Ser Ser Asn Phe Leu Tyr Leu 
    130                 135                 140                 


Gln Val Lys Gly Glu Val Glu Ala Lys Val Glu Glu Leu Lys Phe Asp 
145                 150                 155                 160 


Arg Tyr Ser Val Phe Arg Pro Gly Val Leu Leu Cys Asp Arg Gln Glu 
                165                 170                 175     


Ser Arg Pro Gly Glu Trp Leu Val Arg Lys Phe Phe Gly Ser Leu Pro 
            180                 185                 190         


Asp Ser Trp Ala Ser Gly His Ser Val Pro Val Val Thr Val Val Arg 
        195                 200                 205             


Ala Met Leu Asn Asn Val Val Arg Pro Arg Asp Lys Gln Met Glu Leu 
    210                 215                 220                 


Leu Glu Asn Lys Ala Ile His Asp Leu Gly Lys Ala His Gly Ser Leu 
225                 230                 235                 240 


Lys Pro 
        


<210>  6617
<211>  242
<212>  PRT
<213>  Homo Sapiens

<400>  6617

Met Ala Glu Thr Glu Ala Leu Ser Lys Leu Arg Glu Asp Phe Arg Met 
1               5                   10                  15      


Gln Asn Lys Ser Val Phe Ile Leu Gly Ala Ser Gly Glu Thr Gly Arg 
            20                  25                  30          


Val Leu Leu Lys Glu Ile Leu Glu Gln Gly Leu Phe Ser Lys Val Thr 
        35                  40                  45              


Leu Ile Gly Arg Arg Lys Leu Thr Phe Asp Glu Glu Ala Tyr Lys Asn 
    50                  55                  60                  


Val Asn Gln Glu Val Val Asp Phe Glu Lys Leu Asp Asp Tyr Ala Ser 
65                  70                  75                  80  


Ala Phe Gln Gly His Asp Val Gly Phe Cys Cys Leu Gly Thr Thr Arg 
                85                  90                  95      


Gly Lys Ala Gly Ala Glu Gly Phe Val Arg Val Asp Arg Asp Tyr Val 
            100                 105                 110         


Leu Lys Ser Ala Glu Leu Ala Lys Ala Gly Gly Cys Lys His Phe Asn 
        115                 120                 125             


Leu Leu Ser Ser Lys Gly Ala Asp Lys Ser Ser Asn Phe Leu Tyr Leu 
    130                 135                 140                 


Gln Val Lys Gly Glu Val Glu Ala Lys Val Glu Glu Leu Lys Phe Asp 
145                 150                 155                 160 


Arg Tyr Ser Val Phe Arg Pro Gly Val Leu Leu Cys Asp Arg Gln Glu 
                165                 170                 175     


Ser Arg Pro Gly Glu Trp Leu Val Arg Lys Phe Phe Gly Ser Leu Pro 
            180                 185                 190         


Asp Ser Trp Ala Ser Gly His Ser Val Pro Val Val Thr Val Val Arg 
        195                 200                 205             


Ala Met Leu Asn Asn Val Val Arg Pro Arg Asp Lys Gln Met Glu Leu 
    210                 215                 220                 


Leu Glu Asn Lys Ala Ile His Asp Leu Gly Lys Ala His Gly Ser Leu 
225                 230                 235                 240 


Lys Pro 
        


<210>  6618
<211>  196
<212>  PRT
<213>  Homo Sapiens

<400>  6618

Met Ala Glu Thr Glu Ala Leu Ser Lys Leu Arg Glu Asp Phe Arg Met 
1               5                   10                  15      


Gln Asn Lys Ser Val Phe Ile Leu Gly Ala Ser Gly Glu Thr Gly Arg 
            20                  25                  30          


Val Leu Leu Lys Glu Ile Leu Glu Gln Gly Leu Phe Ser Lys Val Thr 
        35                  40                  45              


Leu Ile Gly Arg Arg Lys Leu Thr Phe Asp Glu Glu Ala Tyr Lys Asn 
    50                  55                  60                  


Val Asn Gln Glu Val Val Asp Phe Glu Lys Leu Asp Asp Tyr Ala Ser 
65                  70                  75                  80  


Ala Phe Gln Gly His Asp Val Gly Phe Cys Cys Leu Gly Thr Thr Arg 
                85                  90                  95      


Gly Lys Ala Gly Ala Gly Glu Val Glu Ala Lys Val Glu Glu Leu Lys 
            100                 105                 110         


Phe Asp Arg Tyr Ser Val Phe Arg Pro Gly Val Leu Leu Cys Asp Arg 
        115                 120                 125             


Gln Glu Ser Arg Pro Gly Glu Trp Leu Val Arg Lys Phe Phe Gly Ser 
    130                 135                 140                 


Leu Pro Asp Ser Trp Ala Ser Gly His Ser Val Pro Val Val Thr Val 
145                 150                 155                 160 


Val Arg Ala Met Leu Asn Asn Val Val Arg Pro Arg Asp Lys Gln Met 
                165                 170                 175     


Glu Leu Leu Glu Asn Lys Ala Ile His Asp Leu Gly Lys Ala His Gly 
            180                 185                 190         


Ser Leu Lys Pro 
        195     


<210>  6619
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  6619

Met Ala Glu Thr Glu Ala Leu Ser Lys Leu Arg Glu Asp Phe Arg Met 
1               5                   10                  15      


Gln Asn Lys Ser Val Phe Ile Leu Gly Ala Ser Gly Glu Thr Gly Arg 
            20                  25                  30          


Val Leu Leu Lys Glu Ile Leu Glu Gln Gly Leu Phe Ser Lys Val Thr 
        35                  40                  45              


Leu Ile Gly Arg Arg Lys Leu Thr Phe Asp Glu Glu Ala Tyr Lys Asn 
    50                  55                  60                  


Val Asn Gln Glu Val Val Asp Phe Glu Lys Leu Asp Asp Tyr Ala Ser 
65                  70                  75                  80  


Ala Phe Gln Gly His Asp Val Gly Phe Cys Cys Leu Gly Thr Thr Arg 
                85                  90                  95      


Gly Lys Ala Gly Ala Val Arg Lys Ala Tyr Ala Leu Phe Pro Phe Cys 
            100                 105                 110         


Trp Pro Val Ile Ser Arg Ile Leu Phe Leu Leu Thr Leu Phe Leu Cys 
        115                 120                 125             


Ala Cys Cys Asn Ala 
    130             


<210>  6620
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  6620

Met Ala Glu Thr Glu Ala Leu Ser Lys Leu Arg Glu Asp Phe Arg Met 
1               5                   10                  15      


Gln Asn Lys Ser Val Phe Ile Leu Gly Ala Ser Gly Glu Thr Gly Arg 
            20                  25                  30          


Val Leu Leu Lys Glu Ile Leu Glu Gln Gly Leu Phe Ser Lys Val Thr 
        35                  40                  45              


Leu Ile Gly Arg Arg Lys Leu Thr Phe Asp Glu Glu Ala Tyr Lys Asn 
    50                  55                  60                  


Val Asn Gln Glu Val Val Asp Phe Glu Lys Leu Asp Asp Tyr Ala Ser 
65                  70                  75                  80  


Ala Phe Gln Gly His Asp Val Gly Phe Cys Cys Leu Gly Thr Thr Arg 
                85                  90                  95      


Gly Lys Ala Gly Ala Val Arg Lys Ala Tyr Ala Leu Phe Pro Phe Cys 
            100                 105                 110         


Trp Pro Val Ile Ser Arg Ile Leu Phe Leu Leu Thr Leu Phe Leu Cys 
        115                 120                 125             


Ala Cys Cys Asn Ala 
    130             


<210>  6621
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  6621

Met Ala Glu Thr Glu Ala Leu Ser Lys Leu Arg Glu Asp Phe Arg Met 
1               5                   10                  15      


Gln Asn Lys Ser Val Phe Ile Leu Gly Ala Ser Gly Glu Thr Gly Arg 
            20                  25                  30          


Val Leu Leu Lys Glu Ile Leu Glu Gln Gly Leu Phe Ser Lys Val Thr 
        35                  40                  45              


Leu Ile Gly Arg Arg Lys Leu Thr Phe Asp Glu Glu Ala Tyr Lys Asn 
    50                  55                  60                  


Val Asn Gln Glu Val Val Asp Phe Glu Lys Leu Asp Asp Tyr Ala Ser 
65                  70                  75                  80  


Ala Phe Gln Gly His Asp Val Gly Phe Cys Cys Leu Gly Thr Thr Arg 
                85                  90                  95      


Gly Lys Ala Gly Ala Val Arg Lys Ala Tyr Ala Leu Phe Pro Phe Cys 
            100                 105                 110         


Trp Pro Val Ile Ser Arg Ile Leu Phe Leu Leu Thr Leu Phe Leu Cys 
        115                 120                 125             


Ala Cys Cys Asn Ala 
    130             


<210>  6622
<211>  276
<212>  PRT
<213>  Homo Sapiens

<400>  6622

Met Ala Gly Pro Ala Ala Leu Ser Ala Ala Ala Ala Ala Ala Leu Ala 
1               5                   10                  15      


Ala Ala Leu Leu Leu Leu Arg Arg Glu Asp Pro Gly Pro Gly Ala Gly 
            20                  25                  30          


Pro Ser Met Ala Glu Thr Glu Ala Leu Ser Lys Leu Arg Glu Asp Phe 
        35                  40                  45              


Arg Met Gln Asn Lys Ser Val Phe Ile Leu Gly Ala Ser Gly Glu Thr 
    50                  55                  60                  


Gly Arg Val Leu Leu Lys Glu Ile Leu Glu Gln Gly Leu Phe Ser Lys 
65                  70                  75                  80  


Val Thr Leu Ile Gly Arg Arg Lys Leu Thr Phe Asp Glu Glu Ala Tyr 
                85                  90                  95      


Lys Asn Val Asn Gln Glu Val Val Asp Phe Glu Lys Leu Asp Asp Tyr 
            100                 105                 110         


Ala Ser Ala Phe Gln Gly His Asp Val Gly Phe Cys Cys Leu Gly Thr 
        115                 120                 125             


Thr Arg Gly Lys Ala Gly Ala Glu Gly Phe Val Arg Val Asp Arg Asp 
    130                 135                 140                 


Tyr Val Leu Lys Ser Ala Glu Leu Ala Lys Ala Gly Gly Cys Lys His 
145                 150                 155                 160 


Phe Asn Leu Leu Ser Ser Lys Gly Ala Asp Lys Ser Ser Asn Phe Leu 
                165                 170                 175     


Tyr Leu Gln Val Lys Gly Glu Val Glu Ala Lys Val Glu Glu Leu Lys 
            180                 185                 190         


Phe Asp Arg Tyr Ser Val Phe Arg Pro Gly Val Leu Leu Cys Asp Arg 
        195                 200                 205             


Gln Glu Ser Arg Pro Gly Glu Trp Leu Val Arg Lys Phe Phe Gly Ser 
    210                 215                 220                 


Leu Pro Asp Ser Trp Ala Ser Gly His Ser Val Pro Val Val Thr Val 
225                 230                 235                 240 


Val Arg Ala Met Leu Asn Asn Val Val Arg Pro Arg Asp Lys Gln Met 
                245                 250                 255     


Glu Leu Leu Glu Asn Lys Ala Ile His Asp Leu Gly Lys Ala His Gly 
            260                 265                 270         


Ser Leu Lys Pro 
        275     


<210>  6623
<211>  57
<212>  PRT
<213>  Homo Sapiens

<400>  6623

Met Lys Phe Phe Val Phe Ala Leu Val Leu Ala Leu Met Ile Ser Met 
1               5                   10                  15      


Ile Ser Ala Asp Ser His Glu Lys Arg His His Gly Tyr Arg Arg Lys 
            20                  25                  30          


Phe His Glu Lys His His Ser His Arg Glu Phe Pro Phe Tyr Gly Asp 
        35                  40                  45              


Tyr Gly Ser Asn Tyr Leu Tyr Asp Asn 
    50                  55          


<210>  6624
<211>  57
<212>  PRT
<213>  Homo Sapiens

<400>  6624

Met Lys Phe Phe Val Phe Ala Leu Val Leu Ala Leu Met Ile Ser Met 
1               5                   10                  15      


Ile Ser Ala Asp Ser His Glu Lys Arg His His Gly Tyr Arg Arg Lys 
            20                  25                  30          


Phe His Glu Lys His His Ser His Arg Glu Phe Pro Phe Tyr Gly Asp 
        35                  40                  45              


Tyr Gly Ser Asn Tyr Leu Tyr Asp Asn 
    50                  55          


<210>  6625
<211>  57
<212>  PRT
<213>  Homo Sapiens

<400>  6625

Met Lys Phe Phe Val Phe Ala Leu Val Leu Ala Leu Met Ile Ser Met 
1               5                   10                  15      


Ile Ser Ala Asp Ser His Glu Lys Arg His His Gly Tyr Arg Arg Lys 
            20                  25                  30          


Phe His Glu Lys His His Ser His Arg Glu Phe Pro Phe Tyr Gly Asp 
        35                  40                  45              


Tyr Gly Ser Asn Tyr Leu Tyr Asp Asn 
    50                  55          


<210>  6626
<211>  41
<212>  PRT
<213>  Homo Sapiens

<400>  6626

Met Lys Phe Phe Val Phe Ala Leu Ile Leu Ala Leu Met Leu Ser Met 
1               5                   10                  15      


Thr Gly Ala Asp Ser His Ala Lys Glu Lys His His Ser His Arg Gly 
            20                  25                  30          


Tyr Arg Ser Asn Tyr Leu Tyr Asp Asn 
        35                  40      


<210>  6627
<211>  51
<212>  PRT
<213>  Homo Sapiens

<400>  6627

Met Lys Phe Phe Val Phe Ala Leu Ile Leu Ala Leu Met Leu Ser Met 
1               5                   10                  15      


Thr Gly Ala Asp Ser His Ala Lys Arg His His Gly Tyr Lys Arg Lys 
            20                  25                  30          


Phe His Glu Lys His His Ser His Arg Gly Tyr Arg Ser Asn Tyr Leu 
        35                  40                  45              


Tyr Asp Asn 
    50      


<210>  6628
<211>  51
<212>  PRT
<213>  Homo Sapiens

<400>  6628

Met Lys Phe Phe Val Phe Ala Leu Ile Leu Ala Leu Met Leu Ser Met 
1               5                   10                  15      


Thr Gly Ala Asp Ser His Ala Lys Arg His His Gly Tyr Lys Arg Lys 
            20                  25                  30          


Phe His Glu Lys His His Ser His Arg Gly Tyr Arg Ser Asn Tyr Leu 
        35                  40                  45              


Tyr Asp Asn 
    50      


<210>  6629
<211>  221
<212>  PRT
<213>  Homo Sapiens

<400>  6629

Gly Lys Leu Pro Val Leu Leu Leu Gly Arg Ser Ser Glu Leu Arg Pro 
1               5                   10                  15      


Gly Glu Phe Val Val Ala Ile Gly Ser Pro Phe Ser Leu Gln Asn Thr 
            20                  25                  30          


Val Thr Thr Gly Ile Val Ser Thr Thr Gln Arg Gly Gly Lys Glu Leu 
        35                  40                  45              


Gly Leu Arg Asn Ser Asp Met Asp Tyr Ile Gln Thr Asp Ala Ile Ile 
    50                  55                  60                  


Asn Tyr Gly Asn Ser Gly Gly Pro Leu Val Asn Leu Asp Gly Glu Val 
65                  70                  75                  80  


Ile Gly Ile Asn Thr Leu Lys Val Thr Ala Gly Ile Ser Phe Ala Ile 
                85                  90                  95      


Pro Ser Asp Lys Ile Lys Lys Phe Leu Thr Glu Ser His Asp Arg Gln 
            100                 105                 110         


Ala Lys Gly Lys Ala Ile Thr Lys Lys Lys Tyr Ile Gly Ile Arg Met 
        115                 120                 125             


Met Ser Leu Thr Ser Ser Lys Ala Lys Glu Leu Lys Asp Arg His Arg 
    130                 135                 140                 


Asp Phe Pro Asp Val Ile Ser Gly Ala Tyr Ile Ile Glu Val Ile Pro 
145                 150                 155                 160 


Asp Thr Pro Ala Glu Ala Gly Gly Leu Lys Glu Asn Asp Val Ile Ile 
                165                 170                 175     


Ser Ile Asn Gly Gln Ser Val Val Ser Ala Asn Asp Val Ser Asp Val 
            180                 185                 190         


Ile Lys Arg Glu Ser Thr Leu Asn Met Val Val Arg Arg Gly Asn Glu 
        195                 200                 205             


Asp Ile Met Ile Thr Val Ile Pro Glu Glu Ile Asp Pro 
    210                 215                 220     


<210>  6630
<211>  480
<212>  PRT
<213>  Homo Sapiens

<400>  6630

Met Gln Ile Pro Arg Ala Ala Leu Leu Pro Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Ala Ala Pro Ala Ser Ala Gln Leu Ser Arg Ala Gly Arg Ser Ala Pro 
            20                  25                  30          


Leu Ala Ala Gly Cys Pro Asp Arg Cys Glu Pro Ala Arg Cys Pro Pro 
        35                  40                  45              


Gln Pro Glu His Cys Glu Gly Gly Arg Ala Arg Asp Ala Cys Gly Cys 
    50                  55                  60                  


Cys Glu Val Cys Gly Ala Pro Glu Gly Ala Ala Cys Gly Leu Gln Glu 
65                  70                  75                  80  


Gly Pro Cys Gly Glu Gly Leu Gln Cys Val Val Pro Phe Gly Val Pro 
                85                  90                  95      


Ala Ser Ala Thr Val Arg Arg Arg Ala Gln Ala Gly Leu Cys Val Cys 
            100                 105                 110         


Ala Ser Ser Glu Pro Val Cys Gly Ser Asp Ala Asn Thr Tyr Ala Asn 
        115                 120                 125             


Leu Cys Gln Leu Arg Ala Ala Ser Arg Arg Ser Glu Arg Leu His Arg 
    130                 135                 140                 


Pro Pro Val Ile Val Leu Gln Arg Gly Ala Cys Gly Gln Gly Gln Glu 
145                 150                 155                 160 


Asp Pro Asn Ser Leu Arg His Lys Tyr Asn Phe Ile Ala Asp Val Val 
                165                 170                 175     


Glu Lys Ile Ala Pro Ala Val Val His Ile Glu Leu Phe Arg Lys Leu 
            180                 185                 190         


Pro Phe Ser Lys Arg Glu Val Pro Val Ala Ser Gly Ser Gly Phe Ile 
        195                 200                 205             


Val Ser Glu Asp Gly Leu Ile Val Thr Asn Ala His Val Val Thr Asn 
    210                 215                 220                 


Lys His Arg Val Lys Val Glu Leu Lys Asn Gly Ala Thr Tyr Glu Ala 
225                 230                 235                 240 


Lys Ile Lys Asp Val Asp Glu Lys Ala Asp Ile Ala Leu Ile Lys Ile 
                245                 250                 255     


Asp His Gln Gly Lys Leu Pro Val Leu Leu Leu Gly Arg Ser Ser Glu 
            260                 265                 270         


Leu Arg Pro Gly Glu Phe Val Val Ala Ile Gly Ser Pro Phe Ser Leu 
        275                 280                 285             


Gln Asn Thr Val Thr Thr Gly Ile Val Ser Thr Thr Gln Arg Gly Gly 
    290                 295                 300                 


Lys Glu Leu Gly Leu Arg Asn Ser Asp Met Asp Tyr Ile Gln Thr Asp 
305                 310                 315                 320 


Ala Ile Ile Asn Tyr Gly Asn Ser Gly Gly Pro Leu Val Asn Leu Asp 
                325                 330                 335     


Gly Glu Val Ile Gly Ile Asn Thr Leu Lys Val Thr Ala Gly Ile Ser 
            340                 345                 350         


Phe Ala Ile Pro Ser Asp Lys Ile Lys Lys Phe Leu Thr Glu Ser His 
        355                 360                 365             


Asp Arg Gln Ala Lys Gly Lys Ala Ile Thr Lys Lys Lys Tyr Ile Gly 
    370                 375                 380                 


Ile Arg Met Met Ser Leu Thr Ser Ser Lys Ala Lys Glu Leu Lys Asp 
385                 390                 395                 400 


Arg His Arg Asp Phe Pro Asp Val Ile Ser Gly Ala Tyr Ile Ile Glu 
                405                 410                 415     


Val Ile Pro Asp Thr Pro Ala Glu Ala Gly Gly Leu Lys Glu Asn Asp 
            420                 425                 430         


Val Ile Ile Ser Ile Asn Gly Gln Ser Val Val Ser Ala Asn Asp Val 
        435                 440                 445             


Ser Asp Val Ile Lys Arg Glu Ser Thr Leu Asn Met Val Val Arg Arg 
    450                 455                 460                 


Gly Asn Glu Asp Ile Met Ile Thr Val Ile Pro Glu Glu Ile Asp Pro 
465                 470                 475                 480 


<210>  6631
<211>  453
<212>  PRT
<213>  Homo Sapiens

<400>  6631

Met Gln Ala Arg Ala Leu Leu Leu Ala Ala Leu Ala Ala Leu Ala Leu 
1               5                   10                  15      


Ala Arg Glu Pro Pro Ala Ala Pro Cys Pro Ala Arg Cys Asp Val Ser 
            20                  25                  30          


Arg Cys Pro Ser Pro Arg Cys Pro Gly Gly Tyr Val Pro Asp Leu Cys 
        35                  40                  45              


Asn Cys Cys Leu Val Cys Ala Ala Ser Glu Gly Glu Pro Cys Gly Gly 
    50                  55                  60                  


Pro Leu Asp Ser Pro Cys Gly Glu Ser Leu Glu Cys Val Arg Gly Leu 
65                  70                  75                  80  


Cys Arg Cys Arg Trp Ser His Ala Val Cys Gly Thr Asp Gly His Thr 
                85                  90                  95      


Tyr Ala Asn Val Cys Ala Leu Gln Ala Ala Ser Arg Arg Ala Leu Gln 
            100                 105                 110         


Leu Ser Gly Thr Pro Val Arg Gln Leu Gln Lys Gly Ala Cys Pro Leu 
        115                 120                 125             


Gly Leu His Gln Leu Ser Ser Pro Arg Tyr Lys Phe Asn Phe Ile Ala 
    130                 135                 140                 


Asp Val Val Glu Lys Ile Ala Pro Ala Val Val His Ile Glu Leu Phe 
145                 150                 155                 160 


Leu Arg His Pro Leu Phe Gly Arg Asn Val Pro Leu Ser Ser Gly Ser 
                165                 170                 175     


Gly Phe Ile Met Ser Glu Ala Gly Leu Ile Ile Thr Asn Ala His Val 
            180                 185                 190         


Val Ser Ser Asn Ser Ala Ala Pro Gly Arg Gln Gln Leu Lys Val Gln 
        195                 200                 205             


Leu Gln Asn Gly Asp Ser Tyr Glu Ala Thr Ile Lys Asp Ile Asp Lys 
    210                 215                 220                 


Lys Ser Asp Ile Ala Thr Ile Lys Ile His Pro Lys Lys Lys Leu Pro 
225                 230                 235                 240 


Val Leu Leu Leu Gly His Ser Ala Asp Leu Arg Pro Gly Glu Phe Val 
                245                 250                 255     


Val Ala Ile Gly Ser Pro Phe Ala Leu Gln Asn Thr Val Thr Thr Gly 
            260                 265                 270         


Ile Val Ser Thr Ala Gln Arg Glu Gly Arg Glu Leu Gly Leu Arg Asp 
        275                 280                 285             


Ser Asp Met Asp Tyr Ile Gln Thr Asp Ala Ile Ile Asn Tyr Gly Asn 
    290                 295                 300                 


Ser Gly Gly Pro Leu Val Asn Leu Asp Gly Glu Val Ile Gly Ile Asn 
305                 310                 315                 320 


Thr Leu Lys Val Thr Ala Gly Ile Ser Phe Ala Ile Pro Ser Asp Arg 
                325                 330                 335     


Ile Thr Arg Phe Leu Thr Glu Phe Gln Asp Lys Gln Ile Lys Asp Trp 
            340                 345                 350         


Lys Lys Arg Phe Ile Gly Ile Arg Met Arg Thr Ile Thr Pro Ser Leu 
        355                 360                 365             


Val Asp Glu Leu Lys Ala Ser Asn Pro Asp Phe Pro Glu Val Ser Ser 
    370                 375                 380                 


Gly Ile Tyr Val Gln Glu Val Ala Pro Asn Ser Pro Ser Gln Arg Gly 
385                 390                 395                 400 


Gly Ile Gln Asp Gly Asp Ile Ile Val Lys Val Asn Gly Arg Pro Leu 
                405                 410                 415     


Val Asp Ser Ser Glu Leu Gln Glu Ala Val Leu Thr Glu Ser Pro Leu 
            420                 425                 430         


Leu Leu Glu Val Arg Arg Gly Asn Asp Asp Leu Leu Phe Ser Ile Ala 
        435                 440                 445             


Pro Glu Val Val Met 
    450             


<210>  6632
<211>  357
<212>  PRT
<213>  Homo Sapiens

<400>  6632

Met Gln Ala Arg Ala Leu Leu Leu Ala Ala Leu Ala Ala Leu Ala Leu 
1               5                   10                  15      


Ala Arg Glu Pro Pro Ala Ala Pro Cys Pro Ala Arg Cys Asp Val Ser 
            20                  25                  30          


Arg Cys Pro Ser Pro Arg Cys Pro Gly Gly Tyr Val Pro Asp Leu Cys 
        35                  40                  45              


Asn Cys Cys Leu Val Cys Ala Ala Ser Glu Gly Glu Pro Cys Gly Gly 
    50                  55                  60                  


Pro Leu Asp Ser Pro Cys Gly Glu Ser Leu Glu Cys Val Arg Gly Leu 
65                  70                  75                  80  


Cys Arg Cys Arg Trp Ser His Ala Val Cys Gly Thr Asp Gly His Thr 
                85                  90                  95      


Tyr Ala Asn Val Cys Ala Leu Gln Ala Ala Ser Arg Arg Ala Leu Gln 
            100                 105                 110         


Leu Ser Gly Thr Pro Val Arg Gln Leu Gln Lys Gly Ala Cys Pro Leu 
        115                 120                 125             


Gly Leu His Gln Leu Ser Ser Pro Arg Tyr Lys Phe Asn Phe Ile Ala 
    130                 135                 140                 


Asp Val Val Glu Lys Ile Ala Pro Ala Val Val His Ile Glu Leu Phe 
145                 150                 155                 160 


Leu Arg His Pro Leu Phe Gly Arg Asn Val Pro Leu Ser Ser Gly Ser 
                165                 170                 175     


Gly Phe Ile Met Ser Glu Ala Gly Leu Ile Ile Thr Asn Ala His Val 
            180                 185                 190         


Val Ser Ser Asn Ser Ala Ala Pro Gly Arg Gln Gln Leu Lys Val Gln 
        195                 200                 205             


Leu Gln Asn Gly Asp Ser Tyr Glu Ala Thr Ile Lys Asp Ile Asp Lys 
    210                 215                 220                 


Lys Ser Asp Ile Ala Thr Ile Lys Ile His Pro Lys Lys Lys Leu Pro 
225                 230                 235                 240 


Val Leu Leu Leu Gly His Ser Ala Asp Leu Arg Pro Gly Glu Phe Val 
                245                 250                 255     


Val Ala Ile Gly Ser Pro Phe Ala Leu Gln Asn Thr Val Thr Thr Gly 
            260                 265                 270         


Ile Val Ser Thr Ala Gln Arg Glu Gly Arg Glu Leu Gly Leu Arg Asp 
        275                 280                 285             


Ser Asp Met Asp Tyr Ile Gln Thr Asp Ala Ile Ile Asn Tyr Gly Asn 
    290                 295                 300                 


Ser Gly Gly Pro Leu Val Asn Leu Asp Gly Glu Val Ile Gly Ile Asn 
305                 310                 315                 320 


Thr Leu Lys Val Thr Ala Gly Ile Ser Phe Ala Ile Pro Ser Asp Arg 
                325                 330                 335     


Ile Thr Arg Phe Leu Thr Glu Phe Gln Asp Lys Gln Ile Lys Ala Pro 
            340                 345                 350         


Ser Leu Ala Val His 
        355         


<210>  6633
<211>  476
<212>  PRT
<213>  Homo Sapiens

<400>  6633

Met Ile Arg Pro Gln Leu Arg Thr Ala Gly Leu Gly Arg Cys Leu Leu 
1               5                   10                  15      


Pro Gly Leu Leu Leu Leu Leu Val Pro Val Leu Trp Ala Gly Ala Glu 
            20                  25                  30          


Lys Leu His Thr Gln Pro Ser Cys Pro Ala Val Cys Gln Pro Thr Arg 
        35                  40                  45              


Cys Pro Ala Leu Pro Thr Cys Ala Leu Gly Thr Thr Pro Val Phe Asp 
    50                  55                  60                  


Leu Cys Arg Cys Cys Arg Val Cys Pro Ala Ala Glu Arg Glu Val Cys 
65                  70                  75                  80  


Gly Gly Ala Gln Gly Gln Pro Cys Ala Pro Gly Leu Gln Cys Leu Gln 
                85                  90                  95      


Pro Leu Arg Pro Gly Phe Pro Ser Thr Cys Gly Cys Pro Thr Leu Gly 
            100                 105                 110         


Gly Ala Val Cys Gly Ser Asp Arg Arg Thr Tyr Pro Ser Met Cys Ala 
        115                 120                 125             


Leu Arg Ala Glu Asn Arg Ala Ala Arg Arg Leu Gly Lys Val Pro Ala 
    130                 135                 140                 


Val Pro Val Gln Trp Gly Asn Cys Gly Asp Thr Gly Thr Arg Ser Ala 
145                 150                 155                 160 


Gly Pro Leu Arg Arg Asn Tyr Asn Phe Ile Ala Ala Val Val Glu Lys 
                165                 170                 175     


Val Ala Pro Ser Val Val His Val Gln Leu Trp Gly Arg Leu Leu His 
            180                 185                 190         


Gly Ser Arg Leu Val Pro Val Tyr Ser Gly Ser Gly Phe Ile Val Ser 
        195                 200                 205             


Glu Asp Gly Leu Ile Ile Thr Asn Ala His Val Val Arg Asn Gln Gln 
    210                 215                 220                 


Trp Ile Glu Val Val Leu Gln Asn Gly Ala Arg Tyr Glu Ala Val Val 
225                 230                 235                 240 


Lys Asp Ile Asp Leu Lys Leu Asp Leu Ala Val Ile Lys Ile Glu Ser 
                245                 250                 255     


Asn Ala Glu Leu Pro Val Leu Met Leu Gly Arg Ser Ser Asp Leu Arg 
            260                 265                 270         


Ala Gly Glu Phe Val Val Ala Leu Gly Ser Pro Phe Ser Leu Gln Asn 
        275                 280                 285             


Thr Ala Thr Ala Gly Ile Val Ser Thr Lys Gln Arg Gly Gly Lys Glu 
    290                 295                 300                 


Leu Gly Met Lys Asp Ser Asp Met Asp Tyr Val Gln Ile Asp Ala Thr 
305                 310                 315                 320 


Ile Asn Tyr Gly Asn Ser Gly Gly Pro Leu Val Asn Leu Asp Gly Asp 
                325                 330                 335     


Val Ile Gly Val Asn Ser Leu Arg Val Thr Asp Gly Ile Ser Phe Ala 
            340                 345                 350         


Ile Pro Ser Asp Arg Val Arg Gln Phe Leu Ala Glu Tyr His Glu His 
        355                 360                 365             


Gln Met Lys Gly Lys Ala Phe Ser Asn Lys Lys Tyr Leu Gly Leu Gln 
    370                 375                 380                 


Met Leu Ser Leu Thr Val Pro Leu Ser Glu Glu Leu Lys Met His Tyr 
385                 390                 395                 400 


Pro Asp Phe Pro Asp Val Ser Ser Gly Val Tyr Val Cys Lys Val Val 
                405                 410                 415     


Glu Gly Thr Ala Ala Gln Ser Ser Gly Leu Arg Asp His Asp Val Ile 
            420                 425                 430         


Val Asn Ile Asn Gly Lys Pro Ile Thr Thr Thr Thr Asp Val Val Lys 
        435                 440                 445             


Ala Leu Asp Ser Asp Ser Leu Ser Met Ala Val Leu Arg Gly Lys Asp 
    450                 455                 460                 


Asn Leu Leu Leu Thr Val Ile Pro Glu Thr Ile Asn 
465                 470                 475     


<210>  6634
<211>  69
<212>  PRT
<213>  Homo Sapiens

<400>  6634

Met Ala Ala His Leu Leu Pro Ile Cys Ala Leu Phe Leu Thr Leu Leu 
1               5                   10                  15      


Asp Met Ala Gln Gly Phe Arg Gly Pro Leu Leu Pro Asn Arg Pro Phe 
            20                  25                  30          


Thr Thr Val Trp Asn Ala Asn Thr Gln Trp Cys Leu Glu Arg His Gly 
        35                  40                  45              


Val Asp Val Asp Val Ser Val Phe Asp Val Val Ala Asn Pro Gly Gln 
    50                  55                  60                  


Thr Phe Arg Gly Pro 
65                  


<210>  6635
<211>  103
<212>  PRT
<213>  Homo Sapiens

<400>  6635

Met Ala Ala His Leu Leu Pro Ile Cys Ala Leu Phe Leu Thr Leu Leu 
1               5                   10                  15      


Asp Met Ala Gln Gly Phe Arg Gly Pro Leu Leu Pro Asn Arg Pro Phe 
            20                  25                  30          


Thr Thr Val Trp Asn Ala Asn Thr Gln Trp Cys Leu Glu Arg His Gly 
        35                  40                  45              


Val Asp Val Asp Val Ser Val Phe Asp Val Val Ala Asn Pro Gly Gln 
    50                  55                  60                  


Thr Phe Arg Gly Pro Asp Met Thr Ile Phe Tyr Ser Ser Gln Leu Gly 
65                  70                  75                  80  


Thr Tyr Pro Tyr Tyr Thr Pro Thr Gly Glu Pro Val Phe Gly Gly Leu 
                85                  90                  95      


Pro Gln Asn Ala Ser Leu Ile 
            100             


<210>  6636
<211>  435
<212>  PRT
<213>  Homo Sapiens

<400>  6636

Met Ala Ala His Leu Leu Pro Ile Cys Ala Leu Phe Leu Thr Leu Leu 
1               5                   10                  15      


Asp Met Ala Gln Gly Phe Arg Gly Pro Leu Leu Pro Asn Arg Pro Phe 
            20                  25                  30          


Thr Thr Val Trp Asn Ala Asn Thr Gln Trp Cys Leu Glu Arg His Gly 
        35                  40                  45              


Val Asp Val Asp Val Ser Val Phe Asp Val Val Ala Asn Pro Gly Gln 
    50                  55                  60                  


Thr Phe Arg Gly Pro Asp Met Thr Ile Phe Tyr Ser Ser Gln Leu Gly 
65                  70                  75                  80  


Thr Tyr Pro Tyr Tyr Thr Pro Thr Gly Glu Pro Val Phe Gly Gly Leu 
                85                  90                  95      


Pro Gln Asn Ala Ser Leu Ile Ala His Leu Ala Arg Thr Phe Gln Asp 
            100                 105                 110         


Ile Leu Ala Ala Ile Pro Ala Pro Asp Phe Ser Gly Leu Ala Val Ile 
        115                 120                 125             


Asp Trp Glu Ala Trp Arg Pro Arg Trp Ala Phe Asn Trp Asp Thr Lys 
    130                 135                 140                 


Asp Ile Tyr Arg Gln Arg Ser Arg Ala Leu Val Gln Ala Gln His Pro 
145                 150                 155                 160 


Asp Trp Pro Ala Pro Gln Val Glu Ala Val Ala Gln Asp Gln Phe Gln 
                165                 170                 175     


Gly Ala Ala Arg Ala Trp Met Ala Gly Thr Leu Gln Leu Gly Arg Ala 
            180                 185                 190         


Leu Arg Pro Arg Gly Leu Trp Gly Phe Tyr Gly Phe Pro Asp Cys Tyr 
        195                 200                 205             


Asn Tyr Asp Phe Leu Ser Pro Asn Tyr Thr Gly Gln Cys Pro Ser Gly 
    210                 215                 220                 


Ile Arg Ala Gln Asn Asp Gln Leu Gly Trp Leu Trp Gly Gln Ser Arg 
225                 230                 235                 240 


Ala Leu Tyr Pro Ser Ile Tyr Met Pro Ala Val Leu Glu Gly Thr Gly 
                245                 250                 255     


Lys Ser Gln Met Tyr Val Gln His Arg Val Ala Glu Ala Phe Arg Val 
            260                 265                 270         


Ala Val Ala Ala Gly Asp Pro Asn Leu Pro Val Leu Pro Tyr Val Gln 
        275                 280                 285             


Ile Phe Tyr Asp Thr Thr Asn His Phe Leu Pro Leu Asp Glu Leu Glu 
    290                 295                 300                 


His Ser Leu Gly Glu Ser Ala Ala Gln Gly Ala Ala Gly Val Val Leu 
305                 310                 315                 320 


Trp Val Ser Trp Glu Asn Thr Arg Thr Lys Glu Ser Cys Gln Ala Ile 
                325                 330                 335     


Lys Glu Tyr Met Asp Thr Thr Leu Gly Pro Phe Ile Leu Asn Val Thr 
            340                 345                 350         


Ser Gly Ala Leu Leu Cys Ser Gln Ala Leu Cys Ser Gly His Gly Arg 
        355                 360                 365             


Cys Val Arg Arg Thr Ser His Pro Lys Ala Leu Leu Leu Leu Asn Pro 
    370                 375                 380                 


Ala Ser Phe Ser Ile Gln Leu Thr Pro Gly Gly Gly Pro Leu Ser Leu 
385                 390                 395                 400 


Arg Gly Ala Leu Ser Leu Glu Asp Gln Ala Gln Met Ala Val Glu Phe 
                405                 410                 415     


Lys Cys Arg Cys Tyr Pro Gly Trp Gln Ala Pro Trp Cys Glu Arg Lys 
            420                 425                 430         


Ser Met Trp 
        435 


<210>  6637
<211>  435
<212>  PRT
<213>  Homo Sapiens

<400>  6637

Met Ala Ala His Leu Leu Pro Ile Cys Ala Leu Phe Leu Thr Leu Leu 
1               5                   10                  15      


Asp Met Ala Gln Gly Phe Arg Gly Pro Leu Leu Pro Asn Arg Pro Phe 
            20                  25                  30          


Thr Thr Val Trp Asn Ala Asn Thr Gln Trp Cys Leu Glu Arg His Gly 
        35                  40                  45              


Val Asp Val Asp Val Ser Val Phe Asp Val Val Ala Asn Pro Gly Gln 
    50                  55                  60                  


Thr Phe Arg Gly Pro Asp Met Thr Ile Phe Tyr Ser Ser Gln Leu Gly 
65                  70                  75                  80  


Thr Tyr Pro Tyr Tyr Thr Pro Thr Gly Glu Pro Val Phe Gly Gly Leu 
                85                  90                  95      


Pro Gln Asn Ala Ser Leu Ile Ala His Leu Ala Arg Thr Phe Gln Asp 
            100                 105                 110         


Ile Leu Ala Ala Ile Pro Ala Pro Asp Phe Ser Gly Leu Ala Val Ile 
        115                 120                 125             


Asp Trp Glu Ala Trp Arg Pro Arg Trp Ala Phe Asn Trp Asp Thr Lys 
    130                 135                 140                 


Asp Ile Tyr Arg Gln Arg Ser Arg Ala Leu Val Gln Ala Gln His Pro 
145                 150                 155                 160 


Asp Trp Pro Ala Pro Gln Val Glu Ala Val Ala Gln Asp Gln Phe Gln 
                165                 170                 175     


Gly Ala Ala Arg Ala Trp Met Ala Gly Thr Leu Gln Leu Gly Arg Ala 
            180                 185                 190         


Leu Arg Pro Arg Gly Leu Trp Gly Phe Tyr Gly Phe Pro Asp Cys Tyr 
        195                 200                 205             


Asn Tyr Asp Phe Leu Ser Pro Asn Tyr Thr Gly Gln Cys Pro Ser Gly 
    210                 215                 220                 


Ile Arg Ala Gln Asn Asp Gln Leu Gly Trp Leu Trp Gly Gln Ser Arg 
225                 230                 235                 240 


Ala Leu Tyr Pro Ser Ile Tyr Met Pro Ala Val Leu Glu Gly Thr Gly 
                245                 250                 255     


Lys Ser Gln Met Tyr Val Gln His Arg Val Ala Glu Ala Phe Arg Val 
            260                 265                 270         


Ala Val Ala Ala Gly Asp Pro Asn Leu Pro Val Leu Pro Tyr Val Gln 
        275                 280                 285             


Ile Phe Tyr Asp Thr Thr Asn His Phe Leu Pro Leu Asp Glu Leu Glu 
    290                 295                 300                 


His Ser Leu Gly Glu Ser Ala Ala Gln Gly Ala Ala Gly Val Val Leu 
305                 310                 315                 320 


Trp Val Ser Trp Glu Asn Thr Arg Thr Lys Glu Ser Cys Gln Ala Ile 
                325                 330                 335     


Lys Glu Tyr Met Asp Thr Thr Leu Gly Pro Phe Ile Leu Asn Val Thr 
            340                 345                 350         


Ser Gly Ala Leu Leu Cys Ser Gln Ala Leu Cys Ser Gly His Gly Arg 
        355                 360                 365             


Cys Val Arg Arg Thr Ser His Pro Lys Ala Leu Leu Leu Leu Asn Pro 
    370                 375                 380                 


Ala Ser Phe Ser Ile Gln Leu Thr Pro Gly Gly Gly Pro Leu Ser Leu 
385                 390                 395                 400 


Arg Gly Ala Leu Ser Leu Glu Asp Gln Ala Gln Met Ala Val Glu Phe 
                405                 410                 415     


Lys Cys Arg Cys Tyr Pro Gly Trp Gln Ala Pro Trp Cys Glu Arg Lys 
            420                 425                 430         


Ser Met Trp 
        435 


<210>  6638
<211>  405
<212>  PRT
<213>  Homo Sapiens

<400>  6638

Met Ala Ala His Leu Leu Pro Ile Cys Ala Leu Phe Leu Thr Leu Leu 
1               5                   10                  15      


Asp Met Ala Gln Gly Phe Arg Gly Pro Leu Leu Pro Asn Arg Pro Phe 
            20                  25                  30          


Thr Thr Val Trp Asn Ala Asn Thr Gln Trp Cys Leu Glu Arg His Gly 
        35                  40                  45              


Val Asp Val Asp Val Ser Val Phe Asp Val Val Ala Asn Pro Gly Gln 
    50                  55                  60                  


Thr Phe Arg Gly Pro Asp Met Thr Ile Phe Tyr Ser Ser Gln Leu Gly 
65                  70                  75                  80  


Thr Tyr Pro Tyr Tyr Thr Pro Thr Gly Glu Pro Val Phe Gly Gly Leu 
                85                  90                  95      


Pro Gln Asn Ala Ser Leu Ile Ala His Leu Ala Arg Thr Phe Gln Asp 
            100                 105                 110         


Ile Leu Ala Ala Ile Pro Ala Pro Asp Phe Ser Gly Leu Ala Val Ile 
        115                 120                 125             


Asp Trp Glu Ala Trp Arg Pro Arg Trp Ala Phe Asn Trp Asp Thr Lys 
    130                 135                 140                 


Asp Ile Tyr Arg Gln Arg Ser Arg Ala Leu Val Gln Ala Gln His Pro 
145                 150                 155                 160 


Asp Trp Pro Ala Pro Gln Val Glu Ala Val Ala Gln Asp Gln Phe Gln 
                165                 170                 175     


Gly Ala Ala Arg Ala Trp Met Ala Gly Thr Leu Gln Leu Gly Arg Ala 
            180                 185                 190         


Leu Arg Pro Arg Gly Leu Trp Gly Phe Tyr Gly Phe Pro Asp Cys Tyr 
        195                 200                 205             


Asn Tyr Asp Phe Leu Ser Pro Asn Tyr Thr Gly Gln Cys Pro Ser Gly 
    210                 215                 220                 


Ile Arg Ala Gln Asn Asp Gln Leu Gly Trp Leu Trp Gly Gln Ser Arg 
225                 230                 235                 240 


Ala Leu Tyr Pro Ser Ile Tyr Met Pro Ala Val Leu Glu Gly Thr Gly 
                245                 250                 255     


Lys Ser Gln Met Tyr Val Gln His Arg Val Ala Glu Ala Phe Arg Val 
            260                 265                 270         


Ala Val Ala Ala Gly Asp Pro Asn Leu Pro Val Leu Pro Tyr Val Gln 
        275                 280                 285             


Ile Phe Tyr Asp Thr Thr Asn His Phe Leu Pro Leu Glu Ser Cys Gln 
    290                 295                 300                 


Ala Ile Lys Glu Tyr Met Asp Thr Thr Leu Gly Pro Phe Ile Leu Asn 
305                 310                 315                 320 


Val Thr Ser Gly Ala Leu Leu Cys Ser Gln Ala Leu Cys Ser Gly His 
                325                 330                 335     


Gly Arg Cys Val Arg Arg Thr Ser His Pro Lys Ala Leu Leu Leu Leu 
            340                 345                 350         


Asn Pro Ala Ser Phe Ser Ile Gln Leu Thr Pro Gly Gly Gly Pro Leu 
        355                 360                 365             


Ser Leu Arg Gly Ala Leu Ser Leu Glu Asp Gln Ala Gln Met Ala Val 
    370                 375                 380                 


Glu Phe Lys Cys Arg Cys Tyr Pro Gly Trp Gln Ala Pro Trp Cys Glu 
385                 390                 395                 400 


Arg Lys Ser Met Trp 
                405 


<210>  6639
<211>  435
<212>  PRT
<213>  Homo Sapiens

<400>  6639

Met Ala Ala His Leu Leu Pro Ile Cys Ala Leu Phe Leu Thr Leu Leu 
1               5                   10                  15      


Asp Met Ala Gln Gly Phe Arg Gly Pro Leu Leu Pro Asn Arg Pro Phe 
            20                  25                  30          


Thr Thr Val Trp Asn Ala Asn Thr Gln Trp Cys Leu Glu Arg His Gly 
        35                  40                  45              


Val Asp Val Asp Val Ser Val Phe Asp Val Val Ala Asn Pro Gly Gln 
    50                  55                  60                  


Thr Phe Arg Gly Pro Asp Met Thr Ile Phe Tyr Ser Ser Gln Leu Gly 
65                  70                  75                  80  


Thr Tyr Pro Tyr Tyr Thr Pro Thr Gly Glu Pro Val Phe Gly Gly Leu 
                85                  90                  95      


Pro Gln Asn Ala Ser Leu Ile Ala His Leu Ala Arg Thr Phe Gln Asp 
            100                 105                 110         


Ile Leu Ala Ala Ile Pro Ala Pro Asp Phe Ser Gly Leu Ala Val Ile 
        115                 120                 125             


Asp Trp Glu Ala Trp Arg Pro Arg Trp Ala Phe Asn Trp Asp Thr Lys 
    130                 135                 140                 


Asp Ile Tyr Arg Gln Arg Ser Arg Ala Leu Val Gln Ala Gln His Pro 
145                 150                 155                 160 


Asp Trp Pro Ala Pro Gln Val Glu Ala Val Ala Gln Asp Gln Phe Gln 
                165                 170                 175     


Gly Ala Ala Arg Ala Trp Met Ala Gly Thr Leu Gln Leu Gly Arg Ala 
            180                 185                 190         


Leu Arg Pro Arg Gly Leu Trp Gly Phe Tyr Gly Phe Pro Asp Cys Tyr 
        195                 200                 205             


Asn Tyr Asp Phe Leu Ser Pro Asn Tyr Thr Gly Gln Cys Pro Ser Gly 
    210                 215                 220                 


Ile Arg Ala Gln Asn Asp Gln Leu Gly Trp Leu Trp Gly Gln Ser Arg 
225                 230                 235                 240 


Ala Leu Tyr Pro Ser Ile Tyr Met Pro Ala Val Leu Glu Gly Thr Gly 
                245                 250                 255     


Lys Ser Gln Met Tyr Val Gln His Arg Val Ala Glu Ala Phe Arg Val 
            260                 265                 270         


Ala Val Ala Ala Gly Asp Pro Asn Leu Pro Val Leu Pro Tyr Val Gln 
        275                 280                 285             


Ile Phe Tyr Asp Thr Thr Asn His Phe Leu Pro Leu Asp Glu Leu Glu 
    290                 295                 300                 


His Ser Leu Gly Glu Ser Ala Ala Gln Gly Ala Ala Gly Val Val Leu 
305                 310                 315                 320 


Trp Val Ser Trp Glu Asn Thr Arg Thr Lys Glu Ser Cys Gln Ala Ile 
                325                 330                 335     


Lys Glu Tyr Met Asp Thr Thr Leu Gly Pro Phe Ile Leu Asn Val Thr 
            340                 345                 350         


Ser Gly Ala Leu Leu Cys Ser Gln Ala Leu Cys Ser Gly His Gly Arg 
        355                 360                 365             


Cys Val Arg Arg Thr Ser His Pro Lys Ala Leu Leu Leu Leu Asn Pro 
    370                 375                 380                 


Ala Ser Phe Ser Ile Gln Leu Thr Pro Gly Gly Gly Pro Leu Ser Leu 
385                 390                 395                 400 


Arg Gly Ala Leu Ser Leu Glu Asp Gln Ala Gln Met Ala Val Glu Phe 
                405                 410                 415     


Lys Cys Arg Cys Tyr Pro Gly Trp Gln Ala Pro Trp Cys Glu Arg Lys 
            420                 425                 430         


Ser Met Trp 
        435 


<210>  6640
<211>  435
<212>  PRT
<213>  Homo Sapiens

<400>  6640

Met Ala Ala His Leu Leu Pro Ile Cys Ala Leu Phe Leu Thr Leu Leu 
1               5                   10                  15      


Asp Met Ala Gln Gly Phe Arg Gly Pro Leu Leu Pro Asn Arg Pro Phe 
            20                  25                  30          


Thr Thr Val Trp Asn Ala Asn Thr Gln Trp Cys Leu Glu Arg His Gly 
        35                  40                  45              


Val Asp Val Asp Val Ser Val Phe Asp Val Val Ala Asn Pro Gly Gln 
    50                  55                  60                  


Thr Phe Arg Gly Pro Asp Met Thr Ile Phe Tyr Ser Ser Gln Leu Gly 
65                  70                  75                  80  


Thr Tyr Pro Tyr Tyr Thr Pro Thr Gly Glu Pro Val Phe Gly Gly Leu 
                85                  90                  95      


Pro Gln Asn Ala Ser Leu Ile Ala His Leu Ala Arg Thr Phe Gln Asp 
            100                 105                 110         


Ile Leu Ala Ala Ile Pro Ala Pro Asp Phe Ser Gly Leu Ala Val Ile 
        115                 120                 125             


Asp Trp Glu Ala Trp Arg Pro Arg Trp Ala Phe Asn Trp Asp Thr Lys 
    130                 135                 140                 


Asp Ile Tyr Arg Gln Arg Ser Arg Ala Leu Val Gln Ala Gln His Pro 
145                 150                 155                 160 


Asp Trp Pro Ala Pro Gln Val Glu Ala Val Ala Gln Asp Gln Phe Gln 
                165                 170                 175     


Gly Ala Ala Arg Ala Trp Met Ala Gly Thr Leu Gln Leu Gly Arg Ala 
            180                 185                 190         


Leu Arg Pro Arg Gly Leu Trp Gly Phe Tyr Gly Phe Pro Asp Cys Tyr 
        195                 200                 205             


Asn Tyr Asp Phe Leu Ser Pro Asn Tyr Thr Gly Gln Cys Pro Ser Gly 
    210                 215                 220                 


Ile Arg Ala Gln Asn Asp Gln Leu Gly Trp Leu Trp Gly Gln Ser Arg 
225                 230                 235                 240 


Ala Leu Tyr Pro Ser Ile Tyr Met Pro Ala Val Leu Glu Gly Thr Gly 
                245                 250                 255     


Lys Ser Gln Met Tyr Val Gln His Arg Val Ala Glu Ala Phe Arg Val 
            260                 265                 270         


Ala Val Ala Ala Gly Asp Pro Asn Leu Pro Val Leu Pro Tyr Val Gln 
        275                 280                 285             


Ile Phe Tyr Asp Thr Thr Asn His Phe Leu Pro Leu Asp Glu Leu Glu 
    290                 295                 300                 


His Ser Leu Gly Glu Ser Ala Ala Gln Gly Ala Ala Gly Val Val Leu 
305                 310                 315                 320 


Trp Val Ser Trp Glu Asn Thr Arg Thr Lys Glu Ser Cys Gln Ala Ile 
                325                 330                 335     


Lys Glu Tyr Met Asp Thr Thr Leu Gly Pro Phe Ile Leu Asn Val Thr 
            340                 345                 350         


Ser Gly Ala Leu Leu Cys Ser Gln Ala Leu Cys Ser Gly His Gly Arg 
        355                 360                 365             


Cys Val Arg Arg Thr Ser His Pro Lys Ala Leu Leu Leu Leu Asn Pro 
    370                 375                 380                 


Ala Ser Phe Ser Ile Gln Leu Thr Pro Gly Gly Gly Pro Leu Ser Leu 
385                 390                 395                 400 


Arg Gly Ala Leu Ser Leu Glu Asp Gln Ala Gln Met Ala Val Glu Phe 
                405                 410                 415     


Lys Cys Arg Cys Tyr Pro Gly Trp Gln Ala Pro Trp Cys Glu Arg Lys 
            420                 425                 430         


Ser Met Trp 
        435 


<210>  6641
<211>  253
<212>  PRT
<213>  Homo Sapiens

<400>  6641

Met Ala Gly Thr Leu Gln Leu Gly Arg Ala Leu Arg Pro Arg Gly Leu 
1               5                   10                  15      


Trp Gly Phe Tyr Gly Phe Pro Asp Cys Tyr Asn Tyr Asp Phe Leu Ser 
            20                  25                  30          


Pro Asn Tyr Thr Gly Gln Cys Pro Ser Gly Ile Arg Ala Gln Asn Asp 
        35                  40                  45              


Gln Leu Gly Trp Leu Trp Gly Gln Ser Arg Ala Leu Tyr Pro Ser Ile 
    50                  55                  60                  


Tyr Met Pro Ala Val Leu Glu Gly Thr Gly Lys Ser Gln Met Tyr Val 
65                  70                  75                  80  


Gln His Arg Val Ala Glu Ala Phe Arg Val Ala Val Ala Ala Gly Asp 
                85                  90                  95      


Pro Asn Leu Pro Val Leu Pro Tyr Val Gln Ile Phe Tyr Asp Thr Thr 
            100                 105                 110         


Asn His Phe Leu Pro Leu Asp Glu Leu Glu His Ser Leu Gly Glu Ser 
        115                 120                 125             


Ala Ala Gln Gly Ala Ala Gly Val Val Leu Trp Val Ser Trp Glu Asn 
    130                 135                 140                 


Thr Arg Thr Lys Glu Ser Cys Gln Ala Ile Lys Glu Tyr Met Asp Thr 
145                 150                 155                 160 


Thr Leu Gly Pro Phe Ile Leu Asn Val Thr Ser Gly Ala Leu Leu Cys 
                165                 170                 175     


Ser Gln Ala Leu Cys Ser Gly His Gly Arg Cys Val Arg Arg Thr Ser 
            180                 185                 190         


His Pro Lys Ala Leu Leu Leu Leu Asn Pro Ala Ser Phe Ser Ile Gln 
        195                 200                 205             


Leu Thr Pro Gly Gly Gly Pro Leu Ser Leu Arg Gly Ala Leu Ser Leu 
    210                 215                 220                 


Glu Asp Gln Ala Gln Met Ala Val Glu Phe Lys Cys Arg Cys Tyr Pro 
225                 230                 235                 240 


Gly Trp Gln Ala Pro Trp Cys Glu Arg Lys Ser Met Trp 
                245                 250             


<210>  6642
<211>  176
<212>  PRT
<213>  Homo Sapiens

<400>  6642

Met Tyr Val Gln His Arg Val Ala Glu Ala Phe Arg Val Ala Val Ala 
1               5                   10                  15      


Ala Gly Asp Pro Asn Leu Pro Val Leu Pro Tyr Val Gln Ile Phe Tyr 
            20                  25                  30          


Asp Thr Thr Asn His Phe Leu Pro Leu Asp Glu Leu Glu His Ser Leu 
        35                  40                  45              


Gly Glu Ser Ala Ala Gln Gly Ala Ala Gly Val Val Leu Trp Val Ser 
    50                  55                  60                  


Trp Glu Asn Thr Arg Thr Lys Glu Ser Cys Gln Ala Ile Lys Glu Tyr 
65                  70                  75                  80  


Met Asp Thr Thr Leu Gly Pro Phe Ile Leu Asn Val Thr Ser Gly Ala 
                85                  90                  95      


Leu Leu Cys Ser Gln Ala Leu Cys Ser Gly His Gly Arg Cys Val Arg 
            100                 105                 110         


Arg Thr Ser His Pro Lys Ala Leu Leu Leu Leu Asn Pro Ala Ser Phe 
        115                 120                 125             


Ser Ile Gln Leu Thr Pro Gly Gly Gly Pro Leu Ser Leu Arg Gly Ala 
    130                 135                 140                 


Leu Ser Leu Glu Asp Gln Ala Gln Met Ala Val Glu Phe Lys Cys Arg 
145                 150                 155                 160 


Cys Tyr Pro Gly Trp Gln Ala Pro Trp Cys Glu Arg Lys Ser Met Trp 
                165                 170                 175     


<210>  6643
<211>  48
<212>  PRT
<213>  Homo Sapiens

<400>  6643

Met Arg Ala Gly Pro Gly Pro Thr Val Thr Leu Ala Leu Val Leu Ala 
1               5                   10                  15      


Val Ser Trp Ala Met Glu Leu Lys Pro Thr Ala Pro Pro Ile Phe Thr 
            20                  25                  30          


Gly Arg Pro Phe Val Val Ala Trp Asp Val Pro Thr Gln Asp Cys Gly 
        35                  40                  45              


<210>  6644
<211>  76
<212>  PRT
<213>  Homo Sapiens

<400>  6644

Met Arg Ala Gly Pro Gly Pro Thr Val Thr Leu Ala Leu Val Leu Ala 
1               5                   10                  15      


Val Ser Trp Ala Met Glu Leu Lys Pro Thr Ala Pro Pro Ile Phe Thr 
            20                  25                  30          


Gly Arg Pro Phe Val Val Ala Trp Asp Val Pro Thr Gln Asp Cys Gly 
        35                  40                  45              


Pro Arg Leu Lys Val Pro Leu Asp Leu Asn Ala Phe Asp Val Gln Ala 
    50                  55                  60                  


Ser Pro Asn Glu Gly Phe Val Asn Gln Asn Ile Thr 
65                  70                  75      


<210>  6645
<211>  81
<212>  PRT
<213>  Homo Sapiens

<400>  6645

Met Arg Ala Gly Pro Gly Pro Thr Val Thr Leu Ala Leu Val Leu Ala 
1               5                   10                  15      


Val Ser Trp Ala Met Glu Leu Lys Pro Thr Ala Pro Pro Ile Phe Thr 
            20                  25                  30          


Gly Arg Pro Phe Val Val Ala Trp Asp Val Pro Thr Gln Asp Cys Gly 
        35                  40                  45              


Pro Arg Leu Lys Val Pro Leu Asp Leu Asn Ala Phe Asp Val Gln Ala 
    50                  55                  60                  


Ser Pro Asn Glu Gly Phe Val Asn Gln Asn Ile Thr Ile Phe Tyr Arg 
65                  70                  75                  80  


Asp 
    


<210>  6646
<211>  117
<212>  PRT
<213>  Homo Sapiens

<400>  6646

Met Arg Ala Gly Pro Gly Pro Thr Val Thr Leu Ala Leu Val Leu Ala 
1               5                   10                  15      


Val Ser Trp Ala Met Glu Leu Lys Pro Thr Ala Pro Pro Ile Phe Thr 
            20                  25                  30          


Gly Arg Pro Phe Val Val Ala Trp Asp Val Pro Thr Gln Asp Cys Gly 
        35                  40                  45              


Pro Arg Leu Lys Val Pro Leu Asp Leu Asn Ala Phe Asp Val Gln Ala 
    50                  55                  60                  


Ser Pro Asn Glu Gly Phe Val Asn Gln Asn Ile Thr Ile Phe Tyr Arg 
65                  70                  75                  80  


Asp Arg Leu Gly Leu Tyr Pro Arg Phe Asp Ser Ala Gly Arg Ser Val 
                85                  90                  95      


His Gly Gly Val Pro Gln Asn Val Ser Leu Trp Ala His Arg Lys Met 
            100                 105                 110         


Leu Gln Lys Arg Val 
        115         


<210>  6647
<211>  121
<212>  PRT
<213>  Homo Sapiens

<400>  6647

Met Arg Ala Gly Pro Gly Pro Thr Val Thr Leu Ala Leu Val Leu Ala 
1               5                   10                  15      


Val Ser Trp Ala Met Glu Leu Lys Pro Thr Ala Pro Pro Ile Phe Thr 
            20                  25                  30          


Gly Arg Pro Phe Val Val Ala Trp Asp Val Pro Thr Gln Asp Cys Gly 
        35                  40                  45              


Pro Arg Leu Lys Val Pro Leu Asp Leu Asn Ala Phe Asp Val Gln Ala 
    50                  55                  60                  


Ser Pro Asn Glu Gly Phe Val Asn Gln Asn Ile Thr Ile Phe Tyr Arg 
65                  70                  75                  80  


Asp Arg Leu Gly Leu Tyr Pro Arg Phe Asp Ser Ala Gly Arg Ser Val 
                85                  90                  95      


His Gly Gly Val Pro Gln Asn Val Ser Leu Trp Ala His Arg Lys Met 
            100                 105                 110         


Leu Gln Lys Arg Val Glu His Tyr Ile 
        115                 120     


<210>  6648
<211>  473
<212>  PRT
<213>  Homo Sapiens

<400>  6648

Met Arg Ala Gly Pro Gly Pro Thr Val Thr Leu Ala Leu Val Leu Ala 
1               5                   10                  15      


Val Ser Trp Ala Met Glu Leu Lys Pro Thr Ala Pro Pro Ile Phe Thr 
            20                  25                  30          


Gly Arg Pro Phe Val Val Ala Trp Asp Val Pro Thr Gln Asp Cys Gly 
        35                  40                  45              


Pro Arg Leu Lys Val Pro Leu Asp Leu Asn Ala Phe Asp Val Gln Ala 
    50                  55                  60                  


Ser Pro Asn Glu Gly Phe Val Asn Gln Asn Ile Thr Ile Phe Tyr Arg 
65                  70                  75                  80  


Asp Arg Leu Gly Leu Tyr Pro Arg Phe Asp Ser Ala Gly Arg Ser Val 
                85                  90                  95      


His Gly Gly Val Pro Gln Asn Val Ser Leu Trp Ala His Arg Lys Met 
            100                 105                 110         


Leu Gln Lys Arg Val Glu His Tyr Ile Arg Thr Gln Glu Ser Ala Gly 
        115                 120                 125             


Leu Ala Val Ile Asp Trp Glu Asp Trp Arg Pro Val Trp Val Arg Asn 
    130                 135                 140                 


Trp Gln Asp Lys Asp Val Tyr Arg Arg Leu Ser Arg Gln Leu Val Ala 
145                 150                 155                 160 


Ser Arg His Pro Asp Trp Pro Pro Asp Arg Ile Val Lys Gln Ala Gln 
                165                 170                 175     


Tyr Glu Phe Glu Phe Ala Ala Gln Gln Phe Met Leu Glu Thr Leu Arg 
            180                 185                 190         


Tyr Val Lys Ala Val Arg Pro Arg His Leu Trp Gly Phe Tyr Leu Phe 
        195                 200                 205             


Pro Asp Cys Tyr Asn His Asp Tyr Val Gln Asn Trp Glu Ser Tyr Thr 
    210                 215                 220                 


Gly Arg Cys Pro Asp Val Glu Val Ala Arg Asn Asp Gln Leu Ala Trp 
225                 230                 235                 240 


Leu Trp Ala Glu Ser Thr Ala Leu Phe Pro Ser Val Tyr Leu Asp Glu 
                245                 250                 255     


Thr Leu Ala Ser Ser Arg His Gly Arg Asn Phe Val Ser Phe Arg Val 
            260                 265                 270         


Gln Glu Ala Leu Arg Val Ala Arg Thr His His Ala Asn His Ala Leu 
        275                 280                 285             


Pro Val Tyr Val Phe Thr Arg Pro Thr Tyr Ser Arg Arg Leu Thr Gly 
    290                 295                 300                 


Leu Ser Glu Met Asp Leu Ile Ser Thr Ile Gly Glu Ser Ala Ala Leu 
305                 310                 315                 320 


Gly Ala Ala Gly Val Ile Leu Trp Gly Asp Ala Gly Tyr Thr Thr Ser 
                325                 330                 335     


Thr Glu Thr Cys Gln Tyr Leu Lys Asp Tyr Leu Thr Arg Leu Leu Val 
            340                 345                 350         


Pro Tyr Val Val Asn Val Ser Trp Ala Thr Gln Tyr Cys Ser Arg Ala 
        355                 360                 365             


Gln Cys His Gly His Gly Arg Cys Val Arg Arg Asn Pro Ser Ala Ser 
    370                 375                 380                 


Thr Phe Leu His Leu Ser Thr Asn Ser Phe Arg Leu Val Pro Gly His 
385                 390                 395                 400 


Ala Pro Gly Glu Pro Gln Leu Arg Pro Val Gly Glu Leu Ser Trp Ala 
                405                 410                 415     


Asp Ile Asp His Leu Gln Thr His Phe Arg Cys Gln Cys Tyr Leu Gly 
            420                 425                 430         


Trp Ser Gly Glu Gln Cys Gln Trp Asp His Arg Gln Ala Ala Gly Gly 
        435                 440                 445             


Ala Ser Glu Ala Trp Ala Gly Ser His Leu Thr Ser Leu Leu Ala Leu 
    450                 455                 460                 


Ala Ala Leu Ala Phe Thr Trp Thr Leu 
465                 470             


<210>  6649
<211>  473
<212>  PRT
<213>  Homo Sapiens

<400>  6649

Met Arg Ala Gly Pro Gly Pro Thr Val Thr Leu Ala Leu Val Leu Ala 
1               5                   10                  15      


Val Ser Trp Ala Met Glu Leu Lys Pro Thr Ala Pro Pro Ile Phe Thr 
            20                  25                  30          


Gly Arg Pro Phe Val Val Ala Trp Asp Val Pro Thr Gln Asp Cys Gly 
        35                  40                  45              


Pro Arg Leu Lys Val Pro Leu Asp Leu Asn Ala Phe Asp Val Gln Ala 
    50                  55                  60                  


Ser Pro Asn Glu Gly Phe Val Asn Gln Asn Ile Thr Ile Phe Tyr Arg 
65                  70                  75                  80  


Asp Arg Leu Gly Leu Tyr Pro Arg Phe Asp Ser Ala Gly Arg Ser Val 
                85                  90                  95      


His Gly Gly Val Pro Gln Asn Val Ser Leu Trp Ala His Arg Lys Met 
            100                 105                 110         


Leu Gln Lys Arg Val Glu His Tyr Ile Arg Thr Gln Glu Ser Ala Gly 
        115                 120                 125             


Leu Ala Val Ile Asp Trp Glu Asp Trp Arg Pro Val Trp Val Arg Asn 
    130                 135                 140                 


Trp Gln Asp Lys Asp Val Tyr Arg Arg Leu Ser Arg Gln Leu Val Ala 
145                 150                 155                 160 


Ser Arg His Pro Asp Trp Pro Pro Asp Arg Ile Val Lys Gln Ala Gln 
                165                 170                 175     


Tyr Glu Phe Glu Phe Ala Ala Gln Gln Phe Met Leu Glu Thr Leu Arg 
            180                 185                 190         


Tyr Val Lys Ala Val Arg Pro Arg His Leu Trp Gly Phe Tyr Leu Phe 
        195                 200                 205             


Pro Asp Cys Tyr Asn His Asp Tyr Val Gln Asn Trp Glu Ser Tyr Thr 
    210                 215                 220                 


Gly Arg Cys Pro Asp Val Glu Val Ala Arg Asn Asp Gln Leu Ala Trp 
225                 230                 235                 240 


Leu Trp Ala Glu Ser Thr Ala Leu Phe Pro Ser Val Tyr Leu Asp Glu 
                245                 250                 255     


Thr Leu Ala Ser Ser Arg His Gly Arg Asn Phe Val Ser Phe Arg Val 
            260                 265                 270         


Gln Glu Ala Leu Arg Val Ala Arg Thr His His Ala Asn His Ala Leu 
        275                 280                 285             


Pro Val Tyr Val Phe Thr Arg Pro Thr Tyr Ser Arg Arg Leu Thr Gly 
    290                 295                 300                 


Leu Ser Glu Met Asp Leu Ile Ser Thr Ile Gly Glu Ser Ala Ala Leu 
305                 310                 315                 320 


Gly Ala Ala Gly Val Ile Leu Trp Gly Asp Ala Gly Tyr Thr Thr Ser 
                325                 330                 335     


Thr Glu Thr Cys Gln Tyr Leu Lys Asp Tyr Leu Thr Arg Leu Leu Val 
            340                 345                 350         


Pro Tyr Val Val Asn Val Ser Trp Ala Thr Gln Tyr Cys Ser Arg Ala 
        355                 360                 365             


Gln Cys His Gly His Gly Arg Cys Val Arg Arg Asn Pro Ser Ala Ser 
    370                 375                 380                 


Thr Phe Leu His Leu Ser Thr Asn Ser Phe Arg Leu Val Pro Gly His 
385                 390                 395                 400 


Ala Pro Gly Glu Pro Gln Leu Arg Pro Val Gly Glu Leu Ser Trp Ala 
                405                 410                 415     


Asp Ile Asp His Leu Gln Thr His Phe Arg Cys Gln Cys Tyr Leu Gly 
            420                 425                 430         


Trp Ser Gly Glu Gln Cys Gln Trp Asp His Arg Gln Ala Ala Gly Gly 
        435                 440                 445             


Ala Ser Glu Ala Trp Ala Gly Ser His Leu Thr Ser Leu Leu Ala Leu 
    450                 455                 460                 


Ala Ala Leu Ala Phe Thr Trp Thr Leu 
465                 470             


<210>  6650
<211>  473
<212>  PRT
<213>  Homo Sapiens

<400>  6650

Met Arg Ala Gly Pro Gly Pro Thr Val Thr Leu Ala Leu Val Leu Ala 
1               5                   10                  15      


Val Ser Trp Ala Met Glu Leu Lys Pro Thr Ala Pro Pro Ile Phe Thr 
            20                  25                  30          


Gly Arg Pro Phe Val Val Ala Trp Asp Val Pro Thr Gln Asp Cys Gly 
        35                  40                  45              


Pro Arg Leu Lys Val Pro Leu Asp Leu Asn Ala Phe Asp Val Gln Ala 
    50                  55                  60                  


Ser Pro Asn Glu Gly Phe Val Asn Gln Asn Ile Thr Ile Phe Tyr Arg 
65                  70                  75                  80  


Asp Arg Leu Gly Leu Tyr Pro Arg Phe Asp Ser Ala Gly Arg Ser Val 
                85                  90                  95      


His Gly Gly Val Pro Gln Asn Val Ser Leu Trp Ala His Arg Lys Met 
            100                 105                 110         


Leu Gln Lys Arg Val Glu His Tyr Ile Arg Thr Gln Glu Ser Ala Gly 
        115                 120                 125             


Leu Ala Val Ile Asp Trp Glu Asp Trp Arg Pro Val Trp Val Arg Asn 
    130                 135                 140                 


Trp Gln Asp Lys Asp Val Tyr Arg Arg Leu Ser Arg Gln Leu Val Ala 
145                 150                 155                 160 


Ser Arg His Pro Asp Trp Pro Pro Asp Arg Ile Val Lys Gln Ala Gln 
                165                 170                 175     


Tyr Glu Phe Glu Phe Ala Ala Gln Gln Phe Met Leu Glu Thr Leu Arg 
            180                 185                 190         


Tyr Val Lys Ala Val Arg Pro Arg His Leu Trp Gly Phe Tyr Leu Phe 
        195                 200                 205             


Pro Asp Cys Tyr Asn His Asp Tyr Val Gln Asn Trp Glu Ser Tyr Thr 
    210                 215                 220                 


Gly Arg Cys Pro Asp Val Glu Val Ala Arg Asn Asp Gln Leu Ala Trp 
225                 230                 235                 240 


Leu Trp Ala Glu Ser Thr Ala Leu Phe Pro Ser Val Tyr Leu Asp Glu 
                245                 250                 255     


Thr Leu Ala Ser Ser Arg His Gly Arg Asn Phe Val Ser Phe Arg Val 
            260                 265                 270         


Gln Glu Ala Leu Arg Val Ala Arg Thr His His Ala Asn His Ala Leu 
        275                 280                 285             


Pro Val Tyr Val Phe Thr Arg Pro Thr Tyr Ser Arg Arg Leu Thr Gly 
    290                 295                 300                 


Leu Ser Glu Met Asp Leu Ile Ser Thr Ile Gly Glu Ser Ala Ala Leu 
305                 310                 315                 320 


Gly Ala Ala Gly Val Ile Leu Trp Gly Asp Ala Gly Tyr Thr Thr Ser 
                325                 330                 335     


Thr Glu Thr Cys Gln Tyr Leu Lys Asp Tyr Leu Thr Arg Leu Leu Val 
            340                 345                 350         


Pro Tyr Val Val Asn Val Ser Trp Ala Thr Gln Tyr Cys Ser Arg Ala 
        355                 360                 365             


Gln Cys His Gly His Gly Arg Cys Val Arg Arg Asn Pro Ser Ala Ser 
    370                 375                 380                 


Thr Phe Leu His Leu Ser Thr Asn Ser Phe Arg Leu Val Pro Gly His 
385                 390                 395                 400 


Ala Pro Gly Glu Pro Gln Leu Arg Pro Val Gly Glu Leu Ser Trp Ala 
                405                 410                 415     


Asp Ile Asp His Leu Gln Thr His Phe Arg Cys Gln Cys Tyr Leu Gly 
            420                 425                 430         


Trp Ser Gly Glu Gln Cys Gln Trp Asp His Arg Gln Ala Ala Gly Gly 
        435                 440                 445             


Ala Ser Glu Ala Trp Ala Gly Ser His Leu Thr Ser Leu Leu Ala Leu 
    450                 455                 460                 


Ala Ala Leu Ala Phe Thr Trp Thr Leu 
465                 470             


<210>  6651
<211>  473
<212>  PRT
<213>  Homo Sapiens

<400>  6651

Met Arg Ala Gly Pro Gly Pro Thr Val Thr Leu Ala Leu Val Leu Ala 
1               5                   10                  15      


Val Ser Trp Ala Met Glu Leu Lys Pro Thr Ala Pro Pro Ile Phe Thr 
            20                  25                  30          


Gly Arg Pro Phe Val Val Ala Trp Asp Val Pro Thr Gln Asp Cys Gly 
        35                  40                  45              


Pro Arg Leu Lys Val Pro Leu Asp Leu Asn Ala Phe Asp Val Gln Ala 
    50                  55                  60                  


Ser Pro Asn Glu Gly Phe Val Asn Gln Asn Ile Thr Ile Phe Tyr Arg 
65                  70                  75                  80  


Asp Arg Leu Gly Leu Tyr Pro Arg Phe Asp Ser Ala Gly Arg Ser Val 
                85                  90                  95      


His Gly Gly Val Pro Gln Asn Val Ser Leu Trp Ala His Arg Lys Met 
            100                 105                 110         


Leu Gln Lys Arg Val Glu His Tyr Ile Arg Thr Gln Glu Ser Ala Gly 
        115                 120                 125             


Leu Ala Val Ile Asp Trp Glu Asp Trp Arg Pro Val Trp Val Arg Asn 
    130                 135                 140                 


Trp Gln Asp Lys Asp Val Tyr Arg Arg Leu Ser Arg Gln Leu Val Ala 
145                 150                 155                 160 


Ser Arg His Pro Asp Trp Pro Pro Asp Arg Ile Val Lys Gln Ala Gln 
                165                 170                 175     


Tyr Glu Phe Glu Phe Ala Ala Gln Gln Phe Met Leu Glu Thr Leu Arg 
            180                 185                 190         


Tyr Val Lys Ala Val Arg Pro Arg His Leu Trp Gly Phe Tyr Leu Phe 
        195                 200                 205             


Pro Asp Cys Tyr Asn His Asp Tyr Val Gln Asn Trp Glu Ser Tyr Thr 
    210                 215                 220                 


Gly Arg Cys Pro Asp Val Glu Val Ala Arg Asn Asp Gln Leu Ala Trp 
225                 230                 235                 240 


Leu Trp Ala Glu Ser Thr Ala Leu Phe Pro Ser Val Tyr Leu Asp Glu 
                245                 250                 255     


Thr Leu Ala Ser Ser Arg His Gly Arg Asn Phe Val Ser Phe Arg Val 
            260                 265                 270         


Gln Glu Ala Leu Arg Val Ala Arg Thr His His Ala Asn His Ala Leu 
        275                 280                 285             


Pro Val Tyr Val Phe Thr Arg Pro Thr Tyr Ser Arg Arg Leu Thr Gly 
    290                 295                 300                 


Leu Ser Glu Met Asp Leu Ile Ser Thr Ile Gly Glu Ser Ala Ala Leu 
305                 310                 315                 320 


Gly Ala Ala Gly Val Ile Leu Trp Gly Asp Ala Gly Tyr Thr Thr Ser 
                325                 330                 335     


Thr Glu Thr Cys Gln Tyr Leu Lys Asp Tyr Leu Thr Arg Leu Leu Val 
            340                 345                 350         


Pro Tyr Val Val Asn Val Ser Trp Ala Thr Gln Tyr Cys Ser Arg Ala 
        355                 360                 365             


Gln Cys His Gly His Gly Arg Cys Val Arg Arg Asn Pro Ser Ala Ser 
    370                 375                 380                 


Thr Phe Leu His Leu Ser Thr Asn Ser Phe Arg Leu Val Pro Gly His 
385                 390                 395                 400 


Ala Pro Gly Glu Pro Gln Leu Arg Pro Val Gly Glu Leu Ser Trp Ala 
                405                 410                 415     


Asp Ile Asp His Leu Gln Thr His Phe Arg Cys Gln Cys Tyr Leu Gly 
            420                 425                 430         


Trp Ser Gly Glu Gln Cys Gln Trp Asp His Arg Gln Ala Ala Gly Gly 
        435                 440                 445             


Ala Ser Glu Ala Trp Ala Gly Ser His Leu Thr Ser Leu Leu Ala Leu 
    450                 455                 460                 


Ala Ala Leu Ala Phe Thr Trp Thr Leu 
465                 470             


<210>  6652
<211>  168
<212>  PRT
<213>  Homo Sapiens

<400>  6652

Met Leu Pro Pro Ala His His Gln Ala Phe Val Arg His Arg Leu Glu 
1               5                   10                  15      


Glu Ala Phe Arg Val Ala Leu Val Gly His Arg His Pro Leu Pro Val 
            20                  25                  30          


Leu Ala Tyr Val Arg Leu Thr His Arg Arg Ser Gly Arg Phe Leu Ser 
        35                  40                  45              


Gln Asp Asp Leu Val Gln Ser Ile Gly Val Ser Ala Ala Leu Gly Ala 
    50                  55                  60                  


Ala Gly Val Val Leu Trp Gly Asp Leu Ser Leu Ser Ser Ser Glu Glu 
65                  70                  75                  80  


Glu Cys Trp His Leu His Asp Tyr Leu Val Asp Thr Leu Gly Pro Tyr 
                85                  90                  95      


Val Ile Asn Val Thr Arg Ala Ala Met Ala Cys Ser His Gln Arg Cys 
            100                 105                 110         


His Gly His Gly Arg Cys Ala Arg Arg Asp Pro Gly Gln Met Glu Ala 
        115                 120                 125             


Phe Leu His Leu Trp Pro Asp Gly Ser Leu Gly Asp Trp Lys Ser Phe 
    130                 135                 140                 


Ser Cys His Cys Tyr Trp Gly Trp Ala Gly Pro Thr Cys Gln Glu Pro 
145                 150                 155                 160 


Arg Pro Gly Pro Lys Glu Ala Val 
                165             


<210>  6653
<211>  138
<212>  PRT
<213>  Homo Sapiens

<400>  6653

Met Leu Pro Pro Ala His His Gln Ala Phe Val Arg His Arg Leu Glu 
1               5                   10                  15      


Glu Ala Phe Arg Val Ala Leu Val Gly His Arg His Pro Leu Pro Val 
            20                  25                  30          


Leu Ala Tyr Val Arg Leu Thr His Arg Arg Ser Gly Arg Phe Leu Ser 
        35                  40                  45              


Gln Glu Glu Cys Trp His Leu His Asp Tyr Leu Val Asp Thr Leu Gly 
    50                  55                  60                  


Pro Tyr Val Ile Asn Val Thr Arg Ala Ala Met Ala Cys Ser His Gln 
65                  70                  75                  80  


Arg Cys His Gly His Gly Arg Cys Ala Arg Arg Asp Pro Gly Gln Met 
                85                  90                  95      


Glu Ala Phe Leu His Leu Trp Pro Asp Gly Ser Leu Gly Asp Trp Lys 
            100                 105                 110         


Ser Phe Ser Cys His Cys Tyr Trp Gly Trp Ala Gly Pro Thr Cys Gln 
        115                 120                 125             


Glu Pro Arg Pro Gly Pro Lys Glu Ala Val 
    130                 135             


<210>  6654
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  6654

Met Thr Thr Gln Leu Gly Pro Ala Leu Val Leu Gly Val Ala Leu Cys 
1               5                   10                  15      


Leu Gly Cys Gly Gln Pro Leu Pro Gln Val Pro Glu Arg Pro Phe Ser 
            20                  25                  30          


Val Leu Trp Asn Val Pro Ser Ala His Cys Glu Ala Arg Phe Gly Val 
        35                  40                  45              


His Leu Pro Leu Asn Ala Leu Gly Ile Ile Ala Asn Arg Gly Gln His 
    50                  55                  60                  


Phe His Gly Gln Asn Met Thr Ile Phe Tyr Lys Asn Gln Leu Gly Leu 
65                  70                  75                  80  


Tyr Pro Tyr Phe Gly Pro Arg Gly Thr Ala His Asn Gly Gly Ile Pro 
                85                  90                  95      


Gln Ala Leu Pro Leu Asp Arg His Leu Ala Leu Ala Ala Tyr Gln Ile 
            100                 105                 110         


His His Ser Leu Arg Pro Gly Phe Ala Gly Pro Ala Val Leu Asp Trp 
        115                 120                 125             


Glu Glu Trp Cys Pro Leu Trp Ala Gly Asn Trp Gly Arg Arg Arg Ala 
    130                 135                 140                 


Tyr Gln Ala Ala Ser Trp Ala Trp Ala Gln Gln Val Phe Pro Asp Leu 
145                 150                 155                 160 


<210>  6655
<211>  417
<212>  PRT
<213>  Homo Sapiens

<400>  6655

Met Thr Thr Gln Leu Gly Pro Ala Leu Val Leu Gly Val Ala Leu Cys 
1               5                   10                  15      


Leu Gly Cys Gly Gln Pro Leu Pro Gln Val Pro Glu Arg Pro Phe Ser 
            20                  25                  30          


Val Leu Trp Asn Val Pro Ser Ala His Cys Glu Ala Arg Phe Gly Val 
        35                  40                  45              


His Leu Pro Leu Asn Ala Leu Gly Ile Ile Ala Asn Arg Gly Gln His 
    50                  55                  60                  


Phe His Gly Gln Asn Met Thr Ile Phe Tyr Lys Asn Gln Leu Gly Leu 
65                  70                  75                  80  


Tyr Pro Tyr Phe Gly Pro Arg Gly Thr Ala His Asn Gly Gly Ile Pro 
                85                  90                  95      


Gln Ala Leu Pro Leu Asp Arg His Leu Ala Leu Ala Ala Tyr Gln Ile 
            100                 105                 110         


His His Ser Leu Arg Pro Gly Phe Ala Gly Pro Ala Val Leu Asp Trp 
        115                 120                 125             


Glu Glu Trp Cys Pro Leu Trp Ala Gly Asn Trp Gly Arg Arg Arg Ala 
    130                 135                 140                 


Tyr Gln Ala Ala Ser Trp Ala Trp Ala Gln Gln Val Phe Pro Asp Leu 
145                 150                 155                 160 


Asp Pro Gln Glu Gln Leu Tyr Lys Ala Tyr Thr Gly Phe Glu Gln Ala 
                165                 170                 175     


Ala Arg Ala Leu Met Glu Asp Thr Leu Arg Val Ala Gln Ala Leu Arg 
            180                 185                 190         


Pro His Gly Leu Trp Gly Phe Tyr His Tyr Pro Ala Cys Gly Asn Gly 
        195                 200                 205             


Trp His Ser Met Ala Ser Asn Tyr Thr Gly Arg Cys His Ala Ala Thr 
    210                 215                 220                 


Leu Ala Arg Asn Thr Gln Leu His Trp Leu Trp Ala Ala Ser Ser Ala 
225                 230                 235                 240 


Leu Phe Pro Ser Ile Tyr Leu Pro Pro Arg Leu Pro Pro Ala His His 
                245                 250                 255     


Gln Ala Phe Val Arg His Arg Leu Glu Glu Ala Phe Arg Val Ala Leu 
            260                 265                 270         


Val Gly His Arg His Pro Leu Pro Val Leu Ala Tyr Val Arg Leu Thr 
        275                 280                 285             


His Arg Arg Ser Gly Arg Phe Leu Ser Gln Asp Asp Leu Val Gln Ser 
    290                 295                 300                 


Ile Gly Val Ser Ala Ala Leu Gly Ala Ala Gly Val Val Leu Trp Gly 
305                 310                 315                 320 


Asp Leu Ser Leu Ser Ser Ser Glu Glu Glu Cys Trp His Leu His Asp 
                325                 330                 335     


Tyr Leu Val Asp Thr Leu Gly Pro Tyr Val Ile Asn Val Thr Arg Ala 
            340                 345                 350         


Ala Met Ala Cys Ser His Gln Arg Cys His Gly His Gly Arg Cys Ala 
        355                 360                 365             


Arg Arg Asp Pro Gly Gln Met Glu Ala Phe Leu His Leu Trp Pro Asp 
    370                 375                 380                 


Gly Ser Leu Gly Asp Trp Lys Ser Phe Ser Cys His Cys Tyr Trp Gly 
385                 390                 395                 400 


Trp Ala Gly Pro Thr Cys Gln Glu Pro Arg Pro Gly Pro Lys Glu Ala 
                405                 410                 415     


Val 
    


<210>  6656
<211>  387
<212>  PRT
<213>  Homo Sapiens

<400>  6656

Met Thr Thr Gln Leu Gly Pro Ala Leu Val Leu Gly Val Ala Leu Cys 
1               5                   10                  15      


Leu Gly Cys Gly Gln Pro Leu Pro Gln Val Pro Glu Arg Pro Phe Ser 
            20                  25                  30          


Val Leu Trp Asn Val Pro Ser Ala His Cys Glu Ala Arg Phe Gly Val 
        35                  40                  45              


His Leu Pro Leu Asn Ala Leu Gly Ile Ile Ala Asn Arg Gly Gln His 
    50                  55                  60                  


Phe His Gly Gln Asn Met Thr Ile Phe Tyr Lys Asn Gln Leu Gly Leu 
65                  70                  75                  80  


Tyr Pro Tyr Phe Gly Pro Arg Gly Thr Ala His Asn Gly Gly Ile Pro 
                85                  90                  95      


Gln Ala Leu Pro Leu Asp Arg His Leu Ala Leu Ala Ala Tyr Gln Ile 
            100                 105                 110         


His His Ser Leu Arg Pro Gly Phe Ala Gly Pro Ala Val Leu Asp Trp 
        115                 120                 125             


Glu Glu Trp Cys Pro Leu Trp Ala Gly Asn Trp Gly Arg Arg Arg Ala 
    130                 135                 140                 


Tyr Gln Ala Ala Ser Trp Ala Trp Ala Gln Gln Val Phe Pro Asp Leu 
145                 150                 155                 160 


Asp Pro Gln Glu Gln Leu Tyr Lys Ala Tyr Thr Gly Phe Glu Gln Ala 
                165                 170                 175     


Ala Arg Ala Leu Met Glu Asp Thr Leu Arg Val Ala Gln Ala Leu Arg 
            180                 185                 190         


Pro His Gly Leu Trp Gly Phe Tyr His Tyr Pro Ala Cys Gly Asn Gly 
        195                 200                 205             


Trp His Ser Met Ala Ser Asn Tyr Thr Gly Arg Cys His Ala Ala Thr 
    210                 215                 220                 


Leu Ala Arg Asn Thr Gln Leu His Trp Leu Trp Ala Ala Ser Ser Ala 
225                 230                 235                 240 


Leu Phe Pro Ser Ile Tyr Leu Pro Pro Arg Leu Pro Pro Ala His His 
                245                 250                 255     


Gln Ala Phe Val Arg His Arg Leu Glu Glu Ala Phe Arg Val Ala Leu 
            260                 265                 270         


Val Gly His Arg His Pro Leu Pro Val Leu Ala Tyr Val Arg Leu Thr 
        275                 280                 285             


His Arg Arg Ser Gly Arg Phe Leu Ser Gln Glu Glu Cys Trp His Leu 
    290                 295                 300                 


His Asp Tyr Leu Val Asp Thr Leu Gly Pro Tyr Val Ile Asn Val Thr 
305                 310                 315                 320 


Arg Ala Ala Met Ala Cys Ser His Gln Arg Cys His Gly His Gly Arg 
                325                 330                 335     


Cys Ala Arg Arg Asp Pro Gly Gln Met Glu Ala Phe Leu His Leu Trp 
            340                 345                 350         


Pro Asp Gly Ser Leu Gly Asp Trp Lys Ser Phe Ser Cys His Cys Tyr 
        355                 360                 365             


Trp Gly Trp Ala Gly Pro Thr Cys Gln Glu Pro Arg Pro Gly Pro Lys 
    370                 375                 380                 


Glu Ala Val 
385         


<210>  6657
<211>  387
<212>  PRT
<213>  Homo Sapiens

<400>  6657

Met Thr Thr Gln Leu Gly Pro Ala Leu Val Leu Gly Val Ala Leu Cys 
1               5                   10                  15      


Leu Gly Cys Gly Gln Pro Leu Pro Gln Val Pro Glu Arg Pro Phe Ser 
            20                  25                  30          


Val Leu Trp Asn Val Pro Ser Ala His Cys Glu Ala Arg Phe Gly Val 
        35                  40                  45              


His Leu Pro Leu Asn Ala Leu Gly Ile Ile Ala Asn Arg Gly Gln His 
    50                  55                  60                  


Phe His Gly Gln Asn Met Thr Ile Phe Tyr Lys Asn Gln Leu Gly Leu 
65                  70                  75                  80  


Tyr Pro Tyr Phe Gly Pro Arg Gly Thr Ala His Asn Gly Gly Ile Pro 
                85                  90                  95      


Gln Ala Leu Pro Leu Asp Arg His Leu Ala Leu Ala Ala Tyr Gln Ile 
            100                 105                 110         


His His Ser Leu Arg Pro Gly Phe Ala Gly Pro Ala Val Leu Asp Trp 
        115                 120                 125             


Glu Glu Trp Cys Pro Leu Trp Ala Gly Asn Trp Gly Arg Arg Arg Ala 
    130                 135                 140                 


Tyr Gln Ala Ala Ser Trp Ala Trp Ala Gln Gln Val Phe Pro Asp Leu 
145                 150                 155                 160 


Asp Pro Gln Glu Gln Leu Tyr Lys Ala Tyr Thr Gly Phe Glu Gln Ala 
                165                 170                 175     


Ala Arg Ala Leu Met Glu Asp Thr Leu Arg Val Ala Gln Ala Leu Arg 
            180                 185                 190         


Pro His Gly Leu Trp Gly Phe Tyr His Tyr Pro Ala Cys Gly Asn Gly 
        195                 200                 205             


Trp His Ser Met Ala Ser Asn Tyr Thr Gly Arg Cys His Ala Ala Thr 
    210                 215                 220                 


Leu Ala Arg Asn Thr Gln Leu His Trp Leu Trp Ala Ala Ser Ser Ala 
225                 230                 235                 240 


Leu Phe Pro Ser Ile Tyr Leu Pro Pro Arg Leu Pro Pro Ala His His 
                245                 250                 255     


Gln Ala Phe Val Arg His Arg Leu Glu Glu Ala Phe Arg Val Ala Leu 
            260                 265                 270         


Val Gly His Arg His Pro Leu Pro Val Leu Ala Tyr Val Arg Leu Thr 
        275                 280                 285             


His Arg Arg Ser Gly Arg Phe Leu Ser Gln Glu Glu Cys Trp His Leu 
    290                 295                 300                 


His Asp Tyr Leu Val Asp Thr Leu Gly Pro Tyr Val Ile Asn Val Thr 
305                 310                 315                 320 


Arg Ala Ala Met Ala Cys Ser His Gln Arg Cys His Gly His Gly Arg 
                325                 330                 335     


Cys Ala Arg Arg Asp Pro Gly Gln Met Glu Ala Phe Leu His Leu Trp 
            340                 345                 350         


Pro Asp Gly Ser Leu Gly Asp Trp Lys Ser Phe Ser Cys His Cys Tyr 
        355                 360                 365             


Trp Gly Trp Ala Gly Pro Thr Cys Gln Glu Pro Arg Pro Gly Pro Lys 
    370                 375                 380                 


Glu Ala Val 
385         


<210>  6658
<211>  417
<212>  PRT
<213>  Homo Sapiens

<400>  6658

Met Thr Thr Gln Leu Gly Pro Ala Leu Val Leu Gly Val Ala Leu Cys 
1               5                   10                  15      


Leu Gly Cys Gly Gln Pro Leu Pro Gln Val Pro Glu Arg Pro Phe Ser 
            20                  25                  30          


Val Leu Trp Asn Val Pro Ser Ala His Cys Glu Ala Arg Phe Gly Val 
        35                  40                  45              


His Leu Pro Leu Asn Ala Leu Gly Ile Ile Ala Asn Arg Gly Gln His 
    50                  55                  60                  


Phe His Gly Gln Asn Met Thr Ile Phe Tyr Lys Asn Gln Leu Gly Leu 
65                  70                  75                  80  


Tyr Pro Tyr Phe Gly Pro Arg Gly Thr Ala His Asn Gly Gly Ile Pro 
                85                  90                  95      


Gln Ala Leu Pro Leu Asp Arg His Leu Ala Leu Ala Ala Tyr Gln Ile 
            100                 105                 110         


His His Ser Leu Arg Pro Gly Phe Ala Gly Pro Ala Val Leu Asp Trp 
        115                 120                 125             


Glu Glu Trp Cys Pro Leu Trp Ala Gly Asn Trp Gly Arg Arg Arg Ala 
    130                 135                 140                 


Tyr Gln Ala Ala Ser Trp Ala Trp Ala Gln Gln Val Phe Pro Asp Leu 
145                 150                 155                 160 


Asp Pro Gln Glu Gln Leu Tyr Lys Ala Tyr Thr Gly Phe Glu Gln Ala 
                165                 170                 175     


Ala Arg Ala Leu Met Glu Asp Thr Leu Arg Val Ala Gln Ala Leu Arg 
            180                 185                 190         


Pro His Gly Leu Trp Gly Phe Tyr His Tyr Pro Ala Cys Gly Asn Gly 
        195                 200                 205             


Trp His Ser Met Ala Ser Asn Tyr Thr Gly Arg Cys His Ala Ala Thr 
    210                 215                 220                 


Leu Ala Arg Asn Thr Gln Leu His Trp Leu Trp Ala Ala Ser Ser Ala 
225                 230                 235                 240 


Leu Phe Pro Ser Ile Tyr Leu Pro Pro Arg Leu Pro Pro Ala His His 
                245                 250                 255     


Gln Ala Phe Val Arg His Arg Leu Glu Glu Ala Phe Arg Val Ala Leu 
            260                 265                 270         


Val Gly His Arg His Pro Leu Pro Val Leu Ala Tyr Val Arg Leu Thr 
        275                 280                 285             


His Arg Arg Ser Gly Arg Phe Leu Ser Gln Asp Asp Leu Val Gln Ser 
    290                 295                 300                 


Ile Gly Val Ser Ala Ala Leu Gly Ala Ala Gly Val Val Leu Trp Gly 
305                 310                 315                 320 


Asp Leu Ser Leu Ser Ser Ser Glu Glu Glu Cys Trp His Leu His Asp 
                325                 330                 335     


Tyr Leu Val Asp Thr Leu Gly Pro Tyr Val Ile Asn Val Thr Arg Ala 
            340                 345                 350         


Ala Met Ala Cys Ser His Gln Arg Cys His Gly His Gly Arg Cys Ala 
        355                 360                 365             


Arg Arg Asp Pro Gly Gln Met Glu Ala Phe Leu His Leu Trp Pro Asp 
    370                 375                 380                 


Gly Ser Leu Gly Asp Trp Lys Ser Phe Ser Cys His Cys Tyr Trp Gly 
385                 390                 395                 400 


Trp Ala Gly Pro Thr Cys Gln Glu Pro Arg Pro Gly Pro Lys Glu Ala 
                405                 410                 415     


Val 
    


<210>  6659
<211>  92
<212>  PRT
<213>  Homo Sapiens

<400>  6659

Met Ala Asp Lys Val Arg Arg Gln Arg Pro Arg Arg Arg Val Cys Trp 
1               5                   10                  15      


Ala Leu Val Ala Val Leu Leu Ala Asp Leu Leu Ala Leu Ser Asp Thr 
            20                  25                  30          


Leu Ala Val Met Ser Val Asp Leu Gly Ser Glu Ser Met Lys Val Ala 
        35                  40                  45              


Ile Val Lys Pro Gly Val Pro Met Glu Ile Val Leu Asn Lys Glu Ser 
    50                  55                  60                  


Arg Arg Lys Thr Pro Val Ile Val Thr Leu Lys Glu Asn Glu Arg Phe 
65                  70                  75                  80  


Phe Gly Asp Ser Ala Ala Ser Met Ala Ile Lys Asn 
                85                  90          


<210>  6660
<211>  103
<212>  PRT
<213>  Homo Sapiens

<400>  6660

Met Ala Asp Lys Val Arg Arg Gln Arg Pro Arg Arg Arg Val Cys Trp 
1               5                   10                  15      


Ala Leu Val Ala Val Leu Leu Ala Asp Leu Leu Ala Leu Ser Asp Thr 
            20                  25                  30          


Leu Ala Val Met Ser Val Asp Leu Gly Ser Glu Ser Met Lys Val Ala 
        35                  40                  45              


Ile Val Lys Pro Gly Val Pro Met Glu Ile Val Leu Asn Lys Glu Ser 
    50                  55                  60                  


Arg Arg Lys Thr Pro Val Ile Val Thr Leu Lys Glu Asn Glu Arg Phe 
65                  70                  75                  80  


Phe Gly Asp Ser Ala Ala Ser Met Ala Ile Lys Asn Pro Lys Ala Thr 
                85                  90                  95      


Leu Arg Tyr Phe Gln His Leu 
            100             


<210>  6661
<211>  149
<212>  PRT
<213>  Homo Sapiens

<400>  6661

Met Ala Asp Lys Val Arg Arg Gln Arg Pro Arg Arg Arg Val Cys Trp 
1               5                   10                  15      


Ala Leu Val Ala Val Leu Leu Ala Asp Leu Leu Ala Leu Ser Asp Thr 
            20                  25                  30          


Leu Ala Val Met Ser Val Asp Leu Gly Ser Glu Ser Met Lys Val Ala 
        35                  40                  45              


Ile Val Lys Pro Gly Val Pro Met Glu Ile Val Leu Asn Lys Glu Ser 
    50                  55                  60                  


Arg Arg Lys Thr Pro Val Ile Val Thr Leu Lys Glu Asn Glu Arg Phe 
65                  70                  75                  80  


Phe Gly Asp Ser Ala Ala Ser Met Ala Ile Lys Asn Pro Lys Ala Thr 
                85                  90                  95      


Leu Arg Tyr Phe Gln His Leu Leu Gly Lys Gln Ala Asp Asn Pro His 
            100                 105                 110         


Val Ala Leu Tyr Gln Ala Arg Phe Pro Glu His Glu Leu Thr Phe Asp 
        115                 120                 125             


Pro Gln Arg Gln Thr Val His Phe Gln Ile Ser Ser Gln Leu Gln Phe 
    130                 135                 140                 


Ser Pro Glu Glu Val 
145                 


<210>  6662
<211>  154
<212>  PRT
<213>  Homo Sapiens

<400>  6662

Met Ala Asp Lys Val Arg Arg Gln Arg Pro Arg Arg Arg Val Cys Trp 
1               5                   10                  15      


Ala Leu Val Ala Val Leu Leu Ala Asp Leu Leu Ala Leu Ser Asp Thr 
            20                  25                  30          


Leu Ala Val Met Ser Val Asp Leu Gly Ser Glu Ser Met Lys Val Ala 
        35                  40                  45              


Ile Val Lys Pro Gly Val Pro Met Glu Ile Val Leu Asn Lys Glu Ser 
    50                  55                  60                  


Arg Arg Lys Thr Pro Val Ile Val Thr Leu Lys Glu Asn Glu Arg Phe 
65                  70                  75                  80  


Phe Gly Asp Ser Ala Ala Ser Met Ala Ile Lys Asn Pro Lys Ala Thr 
                85                  90                  95      


Leu Arg Tyr Phe Gln His Leu Leu Gly Lys Gln Ala Asp Asn Pro His 
            100                 105                 110         


Val Ala Leu Tyr Gln Ala Arg Phe Pro Glu His Glu Leu Thr Phe Asp 
        115                 120                 125             


Pro Gln Arg Gln Thr Val His Phe Gln Ile Ser Ser Gln Leu Gln Phe 
    130                 135                 140                 


Ser Pro Glu Glu Val Leu Gly Met Val Leu 
145                 150                 


<210>  6663
<211>  211
<212>  PRT
<213>  Homo Sapiens

<400>  6663

Met Ala Asp Lys Val Arg Arg Gln Arg Pro Arg Arg Arg Val Cys Trp 
1               5                   10                  15      


Ala Leu Val Ala Val Leu Leu Ala Asp Leu Leu Ala Leu Ser Asp Thr 
            20                  25                  30          


Leu Ala Val Met Ser Val Asp Leu Gly Ser Glu Ser Met Lys Val Ala 
        35                  40                  45              


Ile Val Lys Pro Gly Val Pro Met Glu Ile Val Leu Asn Lys Glu Ser 
    50                  55                  60                  


Arg Arg Lys Thr Pro Val Ile Val Thr Leu Lys Glu Asn Glu Arg Phe 
65                  70                  75                  80  


Phe Gly Asp Ser Ala Ala Ser Met Ala Ile Lys Asn Pro Lys Ala Thr 
                85                  90                  95      


Leu Arg Tyr Phe Gln His Leu Leu Gly Lys Gln Ala Asp Asn Pro His 
            100                 105                 110         


Val Ala Leu Tyr Gln Ala Arg Phe Pro Glu His Glu Leu Thr Phe Asp 
        115                 120                 125             


Pro Gln Arg Gln Thr Val His Phe Gln Ile Ser Ser Gln Leu Gln Phe 
    130                 135                 140                 


Ser Pro Glu Glu Val Leu Gly Met Val Leu Asn Tyr Ser Arg Ser Leu 
145                 150                 155                 160 


Ala Glu Asp Phe Ala Glu Gln Pro Ile Lys Asp Ala Val Ile Thr Val 
                165                 170                 175     


Pro Val Phe Phe Asn Gln Ala Glu Arg Arg Ala Val Leu Gln Ala Ala 
            180                 185                 190         


Arg Met Ala Gly Leu Lys Val Leu Gln Leu Ile Asn Asp Asn Thr Ala 
        195                 200                 205             


Thr Ala Leu 
    210     


<210>  6664
<211>  224
<212>  PRT
<213>  Homo Sapiens

<400>  6664

Met Ala Asp Lys Val Arg Arg Gln Arg Pro Arg Arg Arg Val Cys Trp 
1               5                   10                  15      


Ala Leu Val Ala Val Leu Leu Ala Asp Leu Leu Ala Leu Ser Asp Thr 
            20                  25                  30          


Leu Ala Val Met Ser Val Asp Leu Gly Ser Glu Ser Met Lys Val Ala 
        35                  40                  45              


Ile Val Lys Pro Gly Val Pro Met Glu Ile Val Leu Asn Lys Glu Ser 
    50                  55                  60                  


Arg Arg Lys Thr Pro Val Ile Val Thr Leu Lys Glu Asn Glu Arg Phe 
65                  70                  75                  80  


Phe Gly Asp Ser Ala Ala Ser Met Ala Ile Lys Asn Pro Lys Ala Thr 
                85                  90                  95      


Leu Arg Tyr Phe Gln His Leu Leu Gly Lys Gln Ala Asp Asn Pro His 
            100                 105                 110         


Val Ala Leu Tyr Gln Ala Arg Phe Pro Glu His Glu Leu Thr Phe Asp 
        115                 120                 125             


Pro Gln Arg Gln Thr Val His Phe Gln Ile Ser Ser Gln Leu Gln Phe 
    130                 135                 140                 


Ser Pro Glu Glu Val Leu Gly Met Val Leu Asn Tyr Ser Arg Ser Leu 
145                 150                 155                 160 


Ala Glu Asp Phe Ala Glu Gln Pro Ile Lys Asp Ala Val Ile Thr Val 
                165                 170                 175     


Pro Val Phe Phe Asn Gln Ala Glu Arg Arg Ala Val Leu Gln Ala Ala 
            180                 185                 190         


Arg Met Ala Gly Leu Lys Val Leu Gln Leu Ile Asn Asp Asn Thr Ala 
        195                 200                 205             


Thr Ala Leu Ser Tyr Gly Val Phe Arg Arg Lys Asp Ile Asn Thr Thr 
    210                 215                 220                 


<210>  6665
<211>  656
<212>  PRT
<213>  Homo Sapiens

<400>  6665

Met Ala Asp Lys Val Arg Arg Gln Arg Pro Arg Arg Arg Val Cys Trp 
1               5                   10                  15      


Ala Leu Val Ala Val Leu Leu Ala Asp Leu Leu Ala Leu Ser Asp Thr 
            20                  25                  30          


Leu Ala Val Met Ser Val Asp Leu Gly Ser Glu Ser Met Lys Val Ala 
        35                  40                  45              


Ile Val Lys Pro Gly Val Pro Met Glu Ile Val Leu Asn Lys Glu Ser 
    50                  55                  60                  


Arg Arg Lys Thr Pro Val Ile Val Thr Leu Lys Glu Asn Glu Arg Phe 
65                  70                  75                  80  


Phe Gly Asp Ser Ala Ala Ser Met Ala Ile Lys Asn Pro Lys Ala Thr 
                85                  90                  95      


Leu Arg Tyr Phe Gln His Leu Leu Gly Lys Gln Ala Asp Asn Pro His 
            100                 105                 110         


Val Ala Leu Tyr Gln Ala Arg Phe Pro Glu His Glu Leu Thr Phe Asp 
        115                 120                 125             


Pro Gln Arg Gln Thr Val His Phe Gln Ile Ser Ser Gln Leu Gln Phe 
    130                 135                 140                 


Ser Pro Glu Glu Val Leu Gly Met Val Leu Asn Tyr Ser Arg Ser Leu 
145                 150                 155                 160 


Ala Glu Asp Phe Ala Glu Gln Pro Ile Lys Asp Ala Val Ile Thr Val 
                165                 170                 175     


Pro Val Phe Phe Asn Gln Ala Glu Arg Arg Ala Val Leu Gln Ala Ala 
            180                 185                 190         


Arg Met Ala Gly Leu Lys Val Leu Gln Leu Ile Asn Asp Asn Thr Ala 
        195                 200                 205             


Thr Ala Leu Ser Tyr Gly Val Phe Arg Arg Lys Asp Ile Asn Thr Thr 
    210                 215                 220                 


Ala Gln Asn Ile Met Phe Tyr Asp Met Gly Ser Gly Ser Thr Val Cys 
225                 230                 235                 240 


Thr Ile Val Thr Tyr Gln Met Val Lys Thr Lys Glu Ala Gly Met Gln 
                245                 250                 255     


Pro Gln Leu Gln Ile Arg Gly Val Gly Phe Asp Arg Thr Leu Gly Gly 
            260                 265                 270         


Leu Glu Met Glu Leu Arg Leu Arg Glu Arg Leu Ala Gly Leu Phe Asn 
        275                 280                 285             


Glu Gln Arg Lys Gly Gln Arg Ala Lys Asp Val Arg Glu Asn Pro Arg 
    290                 295                 300                 


Ala Met Ala Lys Leu Leu Arg Glu Ala Asn Arg Leu Lys Thr Val Leu 
305                 310                 315                 320 


Ser Ala Asn Ala Asp His Met Ala Gln Ile Glu Gly Leu Met Asp Asp 
                325                 330                 335     


Val Asp Phe Lys Ala Lys Val Thr Arg Val Glu Phe Glu Glu Leu Cys 
            340                 345                 350         


Ala Asp Leu Phe Glu Arg Val Pro Gly Pro Val Gln Gln Ala Leu Gln 
        355                 360                 365             


Ser Ala Glu Met Ser Leu Asp Glu Ile Glu Gln Val Ile Leu Val Gly 
    370                 375                 380                 


Gly Ala Thr Arg Val Pro Arg Val Gln Glu Val Leu Leu Lys Ala Val 
385                 390                 395                 400 


Gly Lys Glu Glu Leu Gly Lys Asn Ile Asn Ala Asp Glu Ala Ala Ala 
                405                 410                 415     


Met Gly Ala Val Tyr Gln Ala Ala Ala Leu Ser Lys Ala Phe Lys Val 
            420                 425                 430         


Lys Pro Phe Val Val Arg Asp Ala Val Val Tyr Pro Ile Leu Val Glu 
        435                 440                 445             


Phe Thr Arg Glu Val Glu Glu Glu Pro Gly Ile His Ser Leu Lys His 
    450                 455                 460                 


Asn Lys Arg Val Leu Phe Ser Arg Met Gly Pro Tyr Pro Gln Arg Lys 
465                 470                 475                 480 


Val Ile Thr Phe Asn Arg Tyr Ser His Asp Phe Asn Phe His Ile Asn 
                485                 490                 495     


Tyr Gly Asp Leu Gly Phe Leu Gly Pro Glu Asp Leu Arg Val Phe Gly 
            500                 505                 510         


Ser Gln Asn Leu Thr Thr Val Lys Leu Lys Gly Val Gly Asp Ser Phe 
        515                 520                 525             


Lys Lys Tyr Pro Asp Tyr Glu Ser Lys Gly Ile Lys Ala His Phe Asn 
    530                 535                 540                 


Leu Asp Glu Ser Gly Val Leu Ser Leu Asp Arg Val Glu Ser Val Phe 
545                 550                 555                 560 


Glu Thr Leu Val Glu Asp Ser Ala Glu Glu Glu Ser Thr Leu Thr Lys 
                565                 570                 575     


Leu Gly Asn Thr Ile Ser Ser Leu Phe Gly Gly Gly Thr Thr Pro Asp 
            580                 585                 590         


Ala Lys Glu Asn Gly Thr Asp Thr Val Gln Glu Glu Glu Glu Ser Pro 
        595                 600                 605             


Ala Glu Gly Ser Lys Asp Glu Pro Gly Glu Gln Val Glu Leu Lys Glu 
    610                 615                 620                 


Glu Ala Glu Ala Pro Val Glu Asp Gly Ser Gln Pro Pro Pro Pro Glu 
625                 630                 635                 640 


Pro Lys Gly Asp Ala Thr Pro Glu Gly Glu Lys Ala Thr Glu Lys Glu 
                645                 650                 655     


<210>  6666
<211>  937
<212>  PRT
<213>  Homo Sapiens

<400>  6666

Met Ala Asp Lys Val Arg Arg Gln Arg Pro Arg Arg Arg Val Cys Trp 
1               5                   10                  15      


Ala Leu Val Ala Val Leu Leu Ala Asp Leu Leu Ala Leu Ser Asp Thr 
            20                  25                  30          


Leu Ala Val Met Ser Val Asp Leu Gly Ser Glu Ser Met Lys Val Ala 
        35                  40                  45              


Ile Val Lys Pro Gly Val Pro Met Glu Ile Val Leu Asn Lys Glu Ser 
    50                  55                  60                  


Arg Arg Lys Thr Pro Val Ile Val Thr Leu Lys Glu Asn Glu Arg Phe 
65                  70                  75                  80  


Phe Gly Asp Ser Ala Ala Ser Met Ala Ile Lys Asn Pro Lys Ala Thr 
                85                  90                  95      


Leu Arg Tyr Phe Gln His Leu Leu Gly Lys Gln Ala Asp Asn Pro His 
            100                 105                 110         


Val Ala Leu Tyr Gln Ala Arg Phe Pro Glu His Glu Leu Thr Phe Asp 
        115                 120                 125             


Pro Gln Arg Gln Thr Val His Phe Gln Ile Ser Ser Gln Leu Gln Phe 
    130                 135                 140                 


Ser Pro Glu Glu Val Leu Gly Met Val Leu Asn Tyr Ser Arg Ser Leu 
145                 150                 155                 160 


Ala Glu Asp Phe Ala Glu Gln Pro Ile Lys Asp Ala Val Ile Thr Val 
                165                 170                 175     


Pro Val Phe Phe Asn Gln Ala Glu Arg Arg Ala Val Leu Gln Ala Ala 
            180                 185                 190         


Arg Met Ala Gly Leu Lys Val Leu Gln Leu Ile Asn Asp Asn Thr Ala 
        195                 200                 205             


Thr Ala Leu Ser Tyr Gly Val Phe Arg Arg Lys Asp Ile Asn Thr Thr 
    210                 215                 220                 


Ala Gln Asn Ile Met Phe Tyr Asp Met Gly Ser Gly Ser Thr Val Cys 
225                 230                 235                 240 


Thr Ile Val Thr Tyr Gln Met Val Lys Thr Lys Glu Ala Gly Met Gln 
                245                 250                 255     


Pro Gln Leu Gln Ile Arg Gly Val Gly Phe Asp Arg Thr Leu Gly Gly 
            260                 265                 270         


Leu Glu Met Glu Leu Arg Leu Arg Glu Arg Leu Ala Gly Leu Phe Asn 
        275                 280                 285             


Glu Gln Arg Lys Gly Gln Arg Ala Lys Asp Val Arg Glu Asn Pro Arg 
    290                 295                 300                 


Ala Met Ala Lys Leu Leu Arg Glu Ala Asn Arg Leu Lys Thr Val Leu 
305                 310                 315                 320 


Ser Ala Asn Ala Asp His Met Ala Gln Ile Glu Gly Leu Met Asp Asp 
                325                 330                 335     


Val Asp Phe Lys Ala Lys Val Thr Arg Val Glu Phe Glu Glu Leu Cys 
            340                 345                 350         


Ala Asp Leu Phe Glu Arg Val Pro Gly Pro Val Gln Gln Ala Leu Gln 
        355                 360                 365             


Ser Ala Glu Met Ser Leu Asp Glu Ile Glu Gln Val Ile Leu Val Gly 
    370                 375                 380                 


Gly Ala Thr Arg Val Pro Arg Val Gln Glu Val Leu Leu Lys Ala Val 
385                 390                 395                 400 


Gly Lys Glu Glu Leu Gly Lys Asn Ile Asn Ala Asp Glu Ala Ala Ala 
                405                 410                 415     


Met Gly Ala Val Tyr Gln Ala Ala Ala Leu Ser Lys Ala Phe Lys Val 
            420                 425                 430         


Lys Pro Phe Val Val Arg Asp Ala Val Val Tyr Pro Ile Leu Val Glu 
        435                 440                 445             


Phe Thr Arg Glu Val Glu Glu Glu Pro Gly Ile His Ser Leu Lys His 
    450                 455                 460                 


Asn Lys Arg Val Leu Phe Ser Arg Met Gly Pro Tyr Pro Gln Arg Lys 
465                 470                 475                 480 


Val Ile Thr Phe Asn Arg Tyr Ser His Asp Phe Asn Phe His Ile Asn 
                485                 490                 495     


Tyr Gly Asp Leu Gly Phe Leu Gly Pro Glu Asp Leu Arg Val Phe Gly 
            500                 505                 510         


Ser Gln Asn Leu Thr Thr Val Lys Leu Lys Gly Val Gly Asp Ser Phe 
        515                 520                 525             


Lys Lys Tyr Pro Asp Tyr Glu Ser Lys Gly Ile Lys Ala His Phe Asn 
    530                 535                 540                 


Leu Asp Glu Ser Gly Val Leu Ser Leu Asp Arg Val Glu Ser Val Phe 
545                 550                 555                 560 


Glu Thr Leu Val Glu Asp Ser Ala Glu Glu Glu Ser Thr Leu Thr Lys 
                565                 570                 575     


Leu Gly Asn Thr Ile Ser Ser Leu Phe Gly Gly Gly Thr Thr Pro Asp 
            580                 585                 590         


Ala Lys Glu Asn Gly Thr Asp Thr Val Gln Lys Pro Ser Glu Lys Ala 
        595                 600                 605             


Glu Ala Gly Pro Glu Gly Val Ala Pro Ala Pro Glu Gly Glu Lys Lys 
    610                 615                 620                 


Gln Lys Pro Ala Arg Lys Arg Arg Met Val Glu Glu Ile Gly Val Glu 
625                 630                 635                 640 


Leu Val Val Leu Asp Leu Pro Asp Leu Pro Glu Asp Lys Leu Ala Gln 
                645                 650                 655     


Ser Val Gln Lys Leu Gln Asp Leu Thr Leu Arg Asp Leu Glu Lys Gln 
            660                 665                 670         


Glu Arg Glu Lys Ala Ala Asn Ser Leu Glu Ala Phe Ile Phe Glu Thr 
        675                 680                 685             


Gln Asp Lys Leu Tyr Gln Pro Glu Tyr Gln Glu Val Ser Thr Glu Glu 
    690                 695                 700                 


Gln Arg Glu Glu Ile Ser Gly Lys Leu Ser Ala Ala Ser Thr Trp Leu 
705                 710                 715                 720 


Glu Asp Glu Gly Val Gly Ala Thr Thr Val Met Leu Lys Glu Lys Leu 
                725                 730                 735     


Ala Glu Leu Arg Lys Leu Cys Gln Gly Leu Phe Phe Arg Val Glu Glu 
            740                 745                 750         


Arg Lys Lys Trp Pro Glu Arg Leu Ser Ala Leu Asp Asn Leu Leu Asn 
        755                 760                 765             


His Ser Ser Met Phe Leu Lys Gly Ala Arg Leu Ile Pro Glu Met Asp 
    770                 775                 780                 


Gln Ile Phe Thr Glu Val Glu Met Thr Thr Leu Glu Lys Val Ile Asn 
785                 790                 795                 800 


Glu Thr Trp Ala Trp Lys Asn Ala Thr Leu Ala Glu Gln Ala Lys Leu 
                805                 810                 815     


Pro Ala Thr Glu Lys Pro Val Leu Leu Ser Lys Asp Ile Glu Ala Lys 
            820                 825                 830         


Met Met Ala Leu Asp Arg Glu Val Gln Tyr Leu Leu Asn Lys Ala Lys 
        835                 840                 845             


Phe Thr Lys Pro Arg Pro Arg Pro Lys Asp Lys Asn Gly Thr Arg Ala 
    850                 855                 860                 


Glu Pro Pro Leu Asn Ala Ser Ala Ser Asp Gln Gly Glu Lys Val Ile 
865                 870                 875                 880 


Pro Pro Ala Gly Gln Thr Glu Asp Ala Glu Pro Ile Ser Glu Pro Glu 
                885                 890                 895     


Lys Val Glu Thr Gly Ser Glu Pro Gly Asp Thr Glu Pro Leu Glu Leu 
            900                 905                 910         


Gly Gly Pro Gly Ala Glu Pro Glu Gln Lys Glu Gln Ser Thr Gly Gln 
        915                 920                 925             


Lys Arg Pro Leu Lys Asn Asp Glu Leu 
    930                 935         


<210>  6667
<211>  678
<212>  PRT
<213>  Homo Sapiens

<400>  6667

Met Ala Asp Lys Val Arg Arg Gln Arg Pro Arg Arg Arg Val Cys Trp 
1               5                   10                  15      


Ala Leu Val Ala Val Leu Leu Ala Asp Leu Leu Ala Leu Ser Asp Thr 
            20                  25                  30          


Leu Ala Val Met Ser Val Asp Leu Gly Ser Glu Ser Met Lys Val Ala 
        35                  40                  45              


Ile Val Lys Pro Gly Val Pro Met Glu Ile Val Leu Asn Lys Glu Ser 
    50                  55                  60                  


Arg Arg Lys Thr Pro Val Ile Val Thr Leu Lys Glu Asn Glu Arg Phe 
65                  70                  75                  80  


Phe Gly Asp Ser Ala Ala Ser Met Ala Ile Lys Asn Pro Lys Ala Thr 
                85                  90                  95      


Leu Arg Tyr Phe Gln His Leu Leu Gly Lys Gln Ala Asp Asn Pro His 
            100                 105                 110         


Val Ala Leu Tyr Gln Ala Arg Phe Pro Glu His Glu Leu Thr Phe Asp 
        115                 120                 125             


Pro Gln Arg Gln Thr Val His Phe Gln Ile Ser Ser Gln Leu Gln Phe 
    130                 135                 140                 


Ser Pro Glu Glu Val Leu Gly Met Val Leu Asn Tyr Ser Arg Ser Leu 
145                 150                 155                 160 


Ala Glu Asp Phe Ala Glu Gln Pro Ile Lys Asp Ala Val Ile Thr Val 
                165                 170                 175     


Pro Val Phe Phe Asn Gln Ala Glu Arg Arg Ala Val Leu Gln Ala Ala 
            180                 185                 190         


Arg Met Ala Gly Leu Lys Val Leu Gln Leu Ile Asn Asp Asn Thr Ala 
        195                 200                 205             


Thr Ala Leu Ser Tyr Gly Val Phe Arg Arg Lys Asp Ile Asn Thr Thr 
    210                 215                 220                 


Ala Gln Asn Ile Met Phe Tyr Asp Met Gly Ser Gly Ser Thr Val Cys 
225                 230                 235                 240 


Thr Ile Val Thr Tyr Gln Met Val Lys Thr Lys Glu Ala Gly Met Gln 
                245                 250                 255     


Pro Gln Leu Gln Ile Arg Gly Val Gly Phe Asp Arg Thr Leu Gly Gly 
            260                 265                 270         


Leu Glu Met Glu Leu Arg Leu Arg Glu Arg Leu Ala Gly Leu Phe Asn 
        275                 280                 285             


Glu Gln Arg Lys Gly Gln Arg Ala Lys Asp Val Arg Glu Asn Pro Arg 
    290                 295                 300                 


Ala Met Ala Lys Leu Leu Arg Glu Ala Asn Arg Leu Lys Thr Val Leu 
305                 310                 315                 320 


Ser Ala Asn Ala Asp His Met Ala Gln Ile Glu Gly Leu Met Asp Asp 
                325                 330                 335     


Val Asp Phe Lys Ala Lys Val Thr Arg Val Glu Phe Glu Glu Leu Cys 
            340                 345                 350         


Ala Asp Leu Phe Glu Arg Val Pro Gly Pro Val Gln Gln Ala Leu Gln 
        355                 360                 365             


Ser Ala Glu Met Ser Leu Asp Glu Ile Glu Gln Val Ile Leu Val Gly 
    370                 375                 380                 


Gly Ala Thr Arg Val Pro Arg Val Gln Glu Val Leu Leu Lys Ala Val 
385                 390                 395                 400 


Gly Lys Glu Glu Leu Gly Lys Asn Ile Asn Ala Asp Glu Ala Ala Ala 
                405                 410                 415     


Met Gly Ala Val Tyr Gln Ala Ala Ala Leu Ser Lys Ala Phe Lys Val 
            420                 425                 430         


Lys Pro Phe Val Val Arg Asp Ala Val Val Tyr Pro Ile Leu Val Glu 
        435                 440                 445             


Phe Thr Arg Glu Val Glu Glu Glu Pro Gly Ile His Ser Leu Lys His 
    450                 455                 460                 


Asn Lys Arg Val Leu Phe Ser Arg Met Gly Pro Tyr Pro Gln Arg Lys 
465                 470                 475                 480 


Val Ile Thr Phe Asn Arg Tyr Ser His Asp Phe Asn Phe His Ile Asn 
                485                 490                 495     


Tyr Gly Asp Leu Gly Phe Leu Gly Pro Glu Asp Leu Arg Val Phe Gly 
            500                 505                 510         


Ser Gln Asn Leu Thr Thr Val Lys Leu Lys Gly Val Gly Asp Ser Phe 
        515                 520                 525             


Lys Lys Tyr Pro Asp Tyr Glu Ser Lys Gly Ile Lys Ala His Phe Asn 
    530                 535                 540                 


Leu Asp Glu Ser Gly Val Leu Ser Leu Asp Arg Val Glu Ser Val Phe 
545                 550                 555                 560 


Glu Thr Leu Val Glu Asp Ser Ala Glu Glu Glu Ser Thr Leu Thr Lys 
                565                 570                 575     


Leu Gly Asn Thr Ile Ser Ser Leu Phe Gly Gly Gly Thr Thr Pro Asp 
            580                 585                 590         


Ala Lys Glu Asn Gly Thr Asp Thr Val Gln Glu Glu Glu Glu Ser Pro 
        595                 600                 605             


Ala Glu Gly Ser Lys Asp Glu Pro Gly Glu Gln Val Glu Leu Lys Glu 
    610                 615                 620                 


Glu Ala Glu Ala Pro Val Glu Asp Gly Ser Gln Pro Pro Pro Pro Glu 
625                 630                 635                 640 


Pro Lys Gly Asp Ala Thr Pro Glu Gly Glu Lys Ala Thr Glu Lys Glu 
                645                 650                 655     


Asn Gly Asp Lys Ser Glu Ala Gln Lys Pro Val Val Cys Arg Ala Ser 
            660                 665                 670         


Val Thr Arg Phe Gly Phe 
        675             


<210>  6668
<211>  677
<212>  PRT
<213>  Homo Sapiens

<400>  6668

Met Ala Asp Lys Val Arg Arg Gln Arg Pro Arg Arg Arg Val Cys Trp 
1               5                   10                  15      


Ala Leu Val Ala Val Leu Leu Ala Asp Leu Leu Ala Leu Ser Asp Thr 
            20                  25                  30          


Leu Ala Val Met Ser Val Asp Leu Gly Ser Glu Ser Met Lys Val Ala 
        35                  40                  45              


Ile Val Lys Pro Gly Val Pro Met Glu Ile Val Leu Asn Lys Glu Ser 
    50                  55                  60                  


Arg Arg Lys Thr Pro Val Ile Val Thr Leu Lys Glu Asn Glu Arg Phe 
65                  70                  75                  80  


Phe Gly Asp Ser Ala Ala Ser Met Ala Ile Lys Asn Pro Lys Ala Thr 
                85                  90                  95      


Leu Arg Tyr Phe Gln His Leu Leu Gly Lys Gln Ala Asp Asn Pro His 
            100                 105                 110         


Val Ala Leu Tyr Gln Ala Arg Phe Pro Glu His Glu Leu Thr Phe Asp 
        115                 120                 125             


Pro Gln Arg Gln Thr Val His Phe Gln Ile Ser Ser Gln Leu Gln Phe 
    130                 135                 140                 


Ser Pro Glu Glu Val Leu Gly Met Val Leu Asn Tyr Ser Arg Ser Leu 
145                 150                 155                 160 


Ala Glu Asp Phe Ala Glu Gln Pro Ile Lys Asp Ala Val Ile Thr Val 
                165                 170                 175     


Pro Val Phe Phe Asn Gln Ala Glu Arg Arg Ala Val Leu Gln Ala Ala 
            180                 185                 190         


Arg Met Ala Gly Leu Lys Val Leu Gln Leu Ile Asn Asp Asn Thr Ala 
        195                 200                 205             


Thr Ala Leu Ser Tyr Gly Val Phe Arg Arg Lys Asp Ile Asn Thr Thr 
    210                 215                 220                 


Ala Gln Asn Ile Met Phe Tyr Asp Met Gly Ser Gly Ser Thr Val Cys 
225                 230                 235                 240 


Thr Ile Val Thr Tyr Gln Met Val Lys Thr Lys Glu Ala Gly Met Gln 
                245                 250                 255     


Pro Gln Leu Gln Ile Arg Gly Val Gly Phe Asp Arg Thr Leu Gly Gly 
            260                 265                 270         


Leu Glu Met Glu Leu Arg Leu Arg Glu Arg Leu Ala Gly Leu Phe Asn 
        275                 280                 285             


Glu Gln Arg Lys Gly Gln Arg Ala Lys Asp Val Arg Glu Asn Pro Arg 
    290                 295                 300                 


Ala Met Ala Lys Leu Leu Arg Glu Ala Asn Arg Leu Lys Thr Val Leu 
305                 310                 315                 320 


Ser Ala Asn Ala Asp His Met Ala Gln Ile Glu Gly Leu Met Asp Asp 
                325                 330                 335     


Val Asp Phe Lys Ala Lys Val Thr Arg Val Glu Phe Glu Glu Leu Cys 
            340                 345                 350         


Ala Asp Leu Phe Glu Arg Val Pro Gly Pro Val Gln Gln Ala Leu Gln 
        355                 360                 365             


Ser Ala Glu Met Ser Leu Asp Glu Ile Glu Gln Val Ile Leu Val Gly 
    370                 375                 380                 


Gly Ala Thr Arg Val Pro Arg Val Gln Glu Val Leu Leu Lys Ala Val 
385                 390                 395                 400 


Gly Lys Glu Glu Leu Gly Lys Asn Ile Asn Ala Asp Glu Ala Ala Ala 
                405                 410                 415     


Met Gly Ala Val Tyr Gln Ala Ala Ala Leu Ser Lys Ala Phe Lys Val 
            420                 425                 430         


Lys Pro Phe Val Val Arg Asp Ala Val Val Tyr Pro Ile Leu Val Glu 
        435                 440                 445             


Phe Thr Arg Glu Val Glu Glu Glu Pro Gly Ile His Ser Leu Lys His 
    450                 455                 460                 


Asn Lys Arg Val Leu Phe Ser Arg Met Gly Pro Tyr Pro Gln Arg Lys 
465                 470                 475                 480 


Val Ile Thr Phe Asn Arg Tyr Ser His Asp Phe Asn Phe His Ile Asn 
                485                 490                 495     


Tyr Gly Asp Leu Gly Phe Leu Gly Pro Glu Asp Leu Arg Val Phe Gly 
            500                 505                 510         


Ser Gln Asn Leu Thr Thr Val Lys Leu Lys Gly Val Gly Asp Ser Phe 
        515                 520                 525             


Lys Lys Tyr Pro Asp Tyr Glu Ser Lys Gly Ile Lys Ala His Phe Asn 
    530                 535                 540                 


Leu Asp Glu Ser Gly Val Leu Ser Leu Asp Arg Val Glu Ser Val Phe 
545                 550                 555                 560 


Glu Thr Leu Val Glu Asp Ser Ala Glu Glu Glu Ser Thr Leu Thr Lys 
                565                 570                 575     


Leu Gly Asn Thr Ile Ser Ser Leu Phe Gly Gly Gly Thr Thr Pro Asp 
            580                 585                 590         


Ala Lys Glu Asn Gly Thr Asp Thr Val Gln Glu Glu Glu Glu Ser Pro 
        595                 600                 605             


Ala Glu Gly Ser Lys Asp Glu Pro Gly Glu Gln Val Glu Leu Lys Glu 
    610                 615                 620                 


Glu Ala Glu Ala Pro Val Glu Asp Gly Ser Gln Pro Pro Pro Pro Glu 
625                 630                 635                 640 


Pro Lys Gly Asp Ala Thr Pro Glu Gly Glu Lys Ala Thr Glu Lys Glu 
                645                 650                 655     


Asn Gly Asp Lys Ser Glu Ala Gln Ala Ser Val Cys Arg Ala Ser Val 
            660                 665                 670         


Thr Arg Phe Gly Phe 
        675         


<210>  6669
<211>  999
<212>  PRT
<213>  Homo Sapiens

<400>  6669

Met Ala Asp Lys Val Arg Arg Gln Arg Pro Arg Arg Arg Val Cys Trp 
1               5                   10                  15      


Ala Leu Val Ala Val Leu Leu Ala Asp Leu Leu Ala Leu Ser Asp Thr 
            20                  25                  30          


Leu Ala Val Met Ser Val Asp Leu Gly Ser Glu Ser Met Lys Val Ala 
        35                  40                  45              


Ile Val Lys Pro Gly Val Pro Met Glu Ile Val Leu Asn Lys Glu Ser 
    50                  55                  60                  


Arg Arg Lys Thr Pro Val Ile Val Thr Leu Lys Glu Asn Glu Arg Phe 
65                  70                  75                  80  


Phe Gly Asp Ser Ala Ala Ser Met Ala Ile Lys Asn Pro Lys Ala Thr 
                85                  90                  95      


Leu Arg Tyr Phe Gln His Leu Leu Gly Lys Gln Ala Asp Asn Pro His 
            100                 105                 110         


Val Ala Leu Tyr Gln Ala Arg Phe Pro Glu His Glu Leu Thr Phe Asp 
        115                 120                 125             


Pro Gln Arg Gln Thr Val His Phe Gln Ile Ser Ser Gln Leu Gln Phe 
    130                 135                 140                 


Ser Pro Glu Glu Val Leu Gly Met Val Leu Asn Tyr Ser Arg Ser Leu 
145                 150                 155                 160 


Ala Glu Asp Phe Ala Glu Gln Pro Ile Lys Asp Ala Val Ile Thr Val 
                165                 170                 175     


Pro Val Phe Phe Asn Gln Ala Glu Arg Arg Ala Val Leu Gln Ala Ala 
            180                 185                 190         


Arg Met Ala Gly Leu Lys Val Leu Gln Leu Ile Asn Asp Asn Thr Ala 
        195                 200                 205             


Thr Ala Leu Ser Tyr Gly Val Phe Arg Arg Lys Asp Ile Asn Thr Thr 
    210                 215                 220                 


Ala Gln Asn Ile Met Phe Tyr Asp Met Gly Ser Gly Ser Thr Val Cys 
225                 230                 235                 240 


Thr Ile Val Thr Tyr Gln Met Val Lys Thr Lys Glu Ala Gly Met Gln 
                245                 250                 255     


Pro Gln Leu Gln Ile Arg Gly Val Gly Phe Asp Arg Thr Leu Gly Gly 
            260                 265                 270         


Leu Glu Met Glu Leu Arg Leu Arg Glu Arg Leu Ala Gly Leu Phe Asn 
        275                 280                 285             


Glu Gln Arg Lys Gly Gln Arg Ala Lys Asp Val Arg Glu Asn Pro Arg 
    290                 295                 300                 


Ala Met Ala Lys Leu Leu Arg Glu Ala Asn Arg Leu Lys Thr Val Leu 
305                 310                 315                 320 


Ser Ala Asn Ala Asp His Met Ala Gln Ile Glu Gly Leu Met Asp Asp 
                325                 330                 335     


Val Asp Phe Lys Ala Lys Val Thr Arg Val Glu Phe Glu Glu Leu Cys 
            340                 345                 350         


Ala Asp Leu Phe Glu Arg Val Pro Gly Pro Val Gln Gln Ala Leu Gln 
        355                 360                 365             


Ser Ala Glu Met Ser Leu Asp Glu Ile Glu Gln Val Ile Leu Val Gly 
    370                 375                 380                 


Gly Ala Thr Arg Val Pro Arg Val Gln Glu Val Leu Leu Lys Ala Val 
385                 390                 395                 400 


Gly Lys Glu Glu Leu Gly Lys Asn Ile Asn Ala Asp Glu Ala Ala Ala 
                405                 410                 415     


Met Gly Ala Val Tyr Gln Ala Ala Ala Leu Ser Lys Ala Phe Lys Val 
            420                 425                 430         


Lys Pro Phe Val Val Arg Asp Ala Val Val Tyr Pro Ile Leu Val Glu 
        435                 440                 445             


Phe Thr Arg Glu Val Glu Glu Glu Pro Gly Ile His Ser Leu Lys His 
    450                 455                 460                 


Asn Lys Arg Val Leu Phe Ser Arg Met Gly Pro Tyr Pro Gln Arg Lys 
465                 470                 475                 480 


Val Ile Thr Phe Asn Arg Tyr Ser His Asp Phe Asn Phe His Ile Asn 
                485                 490                 495     


Tyr Gly Asp Leu Gly Phe Leu Gly Pro Glu Asp Leu Arg Val Phe Gly 
            500                 505                 510         


Ser Gln Asn Leu Thr Thr Val Lys Leu Lys Gly Val Gly Asp Ser Phe 
        515                 520                 525             


Lys Lys Tyr Pro Asp Tyr Glu Ser Lys Gly Ile Lys Ala His Phe Asn 
    530                 535                 540                 


Leu Asp Glu Ser Gly Val Leu Ser Leu Asp Arg Val Glu Ser Val Phe 
545                 550                 555                 560 


Glu Thr Leu Val Glu Asp Ser Ala Glu Glu Glu Ser Thr Leu Thr Lys 
                565                 570                 575     


Leu Gly Asn Thr Ile Ser Ser Leu Phe Gly Gly Gly Thr Thr Pro Asp 
            580                 585                 590         


Ala Lys Glu Asn Gly Thr Asp Thr Val Gln Glu Glu Glu Glu Ser Pro 
        595                 600                 605             


Ala Glu Gly Ser Lys Asp Glu Pro Gly Glu Gln Val Glu Leu Lys Glu 
    610                 615                 620                 


Glu Ala Glu Ala Pro Val Glu Asp Gly Ser Gln Pro Pro Pro Pro Glu 
625                 630                 635                 640 


Pro Lys Gly Asp Ala Thr Pro Glu Gly Glu Lys Ala Thr Glu Lys Glu 
                645                 650                 655     


Asn Gly Asp Lys Ser Glu Ala Gln Lys Pro Ser Glu Lys Ala Glu Ala 
            660                 665                 670         


Gly Pro Glu Gly Val Ala Pro Ala Pro Glu Gly Glu Lys Lys Gln Lys 
        675                 680                 685             


Pro Ala Arg Lys Arg Arg Met Val Glu Glu Ile Gly Val Glu Leu Val 
    690                 695                 700                 


Val Leu Asp Leu Pro Asp Leu Pro Glu Asp Lys Leu Ala Gln Ser Val 
705                 710                 715                 720 


Gln Lys Leu Gln Asp Leu Thr Leu Arg Asp Leu Glu Lys Gln Glu Arg 
                725                 730                 735     


Glu Lys Ala Ala Asn Ser Leu Glu Ala Phe Ile Phe Glu Thr Gln Asp 
            740                 745                 750         


Lys Leu Tyr Gln Pro Glu Tyr Gln Glu Val Ser Thr Glu Glu Gln Arg 
        755                 760                 765             


Glu Glu Ile Ser Gly Lys Leu Ser Ala Ala Ser Thr Trp Leu Glu Asp 
    770                 775                 780                 


Glu Gly Val Gly Ala Thr Thr Val Met Leu Lys Glu Lys Leu Ala Glu 
785                 790                 795                 800 


Leu Arg Lys Leu Cys Gln Gly Leu Phe Phe Arg Val Glu Glu Arg Lys 
                805                 810                 815     


Lys Trp Pro Glu Arg Leu Ser Ala Leu Asp Asn Leu Leu Asn His Ser 
            820                 825                 830         


Ser Met Phe Leu Lys Gly Ala Arg Leu Ile Pro Glu Met Asp Gln Ile 
        835                 840                 845             


Phe Thr Glu Val Glu Met Thr Thr Leu Glu Lys Val Ile Asn Glu Thr 
    850                 855                 860                 


Trp Ala Trp Lys Asn Ala Thr Leu Ala Glu Gln Ala Lys Leu Pro Ala 
865                 870                 875                 880 


Thr Glu Lys Pro Val Leu Leu Ser Lys Asp Ile Glu Ala Lys Met Met 
                885                 890                 895     


Ala Leu Asp Arg Glu Val Gln Tyr Leu Leu Asn Lys Ala Lys Phe Thr 
            900                 905                 910         


Lys Pro Arg Pro Arg Pro Lys Asp Lys Asn Gly Thr Arg Ala Glu Pro 
        915                 920                 925             


Pro Leu Asn Ala Ser Ala Ser Asp Gln Gly Glu Lys Val Ile Pro Pro 
    930                 935                 940                 


Ala Gly Gln Thr Glu Asp Ala Glu Pro Ile Ser Glu Pro Glu Lys Val 
945                 950                 955                 960 


Glu Thr Gly Ser Glu Pro Gly Asp Thr Glu Pro Leu Glu Leu Gly Gly 
                965                 970                 975     


Pro Gly Ala Glu Pro Glu Gln Lys Glu Gln Ser Thr Gly Gln Lys Arg 
            980                 985                 990         


Pro Leu Lys Asn Asp Glu Leu 
        995                 


<210>  6670
<211>  937
<212>  PRT
<213>  Homo Sapiens

<400>  6670

Met Ala Asp Lys Val Arg Arg Gln Arg Pro Arg Arg Arg Val Cys Trp 
1               5                   10                  15      


Ala Leu Val Ala Val Leu Leu Ala Asp Leu Leu Ala Leu Ser Asp Thr 
            20                  25                  30          


Leu Ala Val Met Ser Val Asp Leu Gly Ser Glu Ser Met Lys Val Ala 
        35                  40                  45              


Ile Val Lys Pro Gly Val Pro Met Glu Ile Val Leu Asn Lys Glu Ser 
    50                  55                  60                  


Arg Arg Lys Thr Pro Val Ile Val Thr Leu Lys Glu Asn Glu Arg Phe 
65                  70                  75                  80  


Phe Gly Asp Ser Ala Ala Ser Met Ala Ile Lys Asn Pro Lys Ala Thr 
                85                  90                  95      


Leu Arg Tyr Phe Gln His Leu Leu Gly Lys Gln Ala Asp Asn Pro His 
            100                 105                 110         


Val Ala Leu Tyr Gln Ala Arg Phe Pro Glu His Glu Leu Thr Phe Asp 
        115                 120                 125             


Pro Gln Arg Gln Thr Val His Phe Gln Ile Ser Ser Gln Leu Gln Phe 
    130                 135                 140                 


Ser Pro Glu Glu Val Leu Gly Met Val Leu Asn Tyr Ser Arg Ser Leu 
145                 150                 155                 160 


Ala Glu Asp Phe Ala Glu Gln Pro Ile Lys Asp Ala Val Ile Thr Val 
                165                 170                 175     


Pro Val Phe Phe Asn Gln Ala Glu Arg Arg Ala Val Leu Gln Ala Ala 
            180                 185                 190         


Arg Met Ala Gly Leu Lys Val Leu Gln Leu Ile Asn Asp Asn Thr Ala 
        195                 200                 205             


Thr Ala Leu Ser Tyr Gly Val Phe Arg Arg Lys Asp Ile Asn Thr Thr 
    210                 215                 220                 


Ala Gln Asn Ile Met Phe Tyr Asp Met Gly Ser Gly Ser Thr Val Cys 
225                 230                 235                 240 


Thr Ile Val Thr Tyr Gln Met Val Lys Thr Lys Glu Ala Gly Met Gln 
                245                 250                 255     


Pro Gln Leu Gln Ile Arg Gly Val Gly Phe Asp Arg Thr Leu Gly Gly 
            260                 265                 270         


Leu Glu Met Glu Leu Arg Leu Arg Glu Arg Leu Ala Gly Leu Phe Asn 
        275                 280                 285             


Glu Gln Arg Lys Gly Gln Arg Ala Lys Asp Val Arg Glu Asn Pro Arg 
    290                 295                 300                 


Ala Met Ala Lys Leu Leu Arg Glu Ala Asn Arg Leu Lys Thr Val Leu 
305                 310                 315                 320 


Ser Ala Asn Ala Asp His Met Ala Gln Ile Glu Gly Leu Met Asp Asp 
                325                 330                 335     


Val Asp Phe Lys Ala Lys Val Thr Arg Val Glu Phe Glu Glu Leu Cys 
            340                 345                 350         


Ala Asp Leu Phe Glu Arg Val Pro Gly Pro Val Gln Gln Ala Leu Gln 
        355                 360                 365             


Ser Ala Glu Met Ser Leu Asp Glu Ile Glu Gln Val Ile Leu Val Gly 
    370                 375                 380                 


Gly Ala Thr Arg Val Pro Arg Val Gln Glu Val Leu Leu Lys Ala Val 
385                 390                 395                 400 


Gly Lys Glu Glu Leu Gly Lys Asn Ile Asn Ala Asp Glu Ala Ala Ala 
                405                 410                 415     


Met Gly Ala Val Tyr Gln Ala Ala Ala Leu Ser Lys Ala Phe Lys Val 
            420                 425                 430         


Lys Pro Phe Val Val Arg Asp Ala Val Val Tyr Pro Ile Leu Val Glu 
        435                 440                 445             


Phe Thr Arg Glu Val Glu Glu Glu Pro Gly Ile His Ser Leu Lys His 
    450                 455                 460                 


Asn Lys Arg Val Leu Phe Ser Arg Met Gly Pro Tyr Pro Gln Arg Lys 
465                 470                 475                 480 


Val Ile Thr Phe Asn Arg Tyr Ser His Asp Phe Asn Phe His Ile Asn 
                485                 490                 495     


Tyr Gly Asp Leu Gly Phe Leu Gly Pro Glu Asp Leu Arg Val Phe Gly 
            500                 505                 510         


Ser Gln Asn Leu Thr Thr Val Lys Leu Lys Gly Val Gly Asp Ser Phe 
        515                 520                 525             


Lys Lys Tyr Pro Asp Tyr Glu Ser Lys Gly Ile Lys Ala His Phe Asn 
    530                 535                 540                 


Leu Asp Glu Ser Gly Val Leu Ser Leu Asp Arg Val Glu Ser Val Phe 
545                 550                 555                 560 


Glu Thr Leu Val Glu Asp Ser Ala Glu Glu Glu Ser Thr Leu Thr Lys 
                565                 570                 575     


Leu Gly Asn Thr Ile Ser Ser Leu Phe Gly Gly Gly Thr Thr Pro Asp 
            580                 585                 590         


Ala Lys Glu Asn Gly Thr Asp Thr Val Gln Lys Pro Ser Glu Lys Ala 
        595                 600                 605             


Glu Ala Gly Pro Glu Gly Val Ala Pro Ala Pro Glu Gly Glu Lys Lys 
    610                 615                 620                 


Gln Lys Pro Ala Arg Lys Arg Arg Met Val Glu Glu Ile Gly Val Glu 
625                 630                 635                 640 


Leu Val Val Leu Asp Leu Pro Asp Leu Pro Glu Asp Lys Leu Ala Gln 
                645                 650                 655     


Ser Val Gln Lys Leu Gln Asp Leu Thr Leu Arg Asp Leu Glu Lys Gln 
            660                 665                 670         


Glu Arg Glu Lys Ala Ala Asn Ser Leu Glu Ala Phe Ile Phe Glu Thr 
        675                 680                 685             


Gln Asp Lys Leu Tyr Gln Pro Glu Tyr Gln Glu Val Ser Thr Glu Glu 
    690                 695                 700                 


Gln Arg Glu Glu Ile Ser Gly Lys Leu Ser Ala Ala Ser Thr Trp Leu 
705                 710                 715                 720 


Glu Asp Glu Gly Val Gly Ala Thr Thr Val Met Leu Lys Glu Lys Leu 
                725                 730                 735     


Ala Glu Leu Arg Lys Leu Cys Gln Gly Leu Phe Phe Arg Val Glu Glu 
            740                 745                 750         


Arg Lys Lys Trp Pro Glu Arg Leu Ser Ala Leu Asp Asn Leu Leu Asn 
        755                 760                 765             


His Ser Ser Met Phe Leu Lys Gly Ala Arg Leu Ile Pro Glu Met Asp 
    770                 775                 780                 


Gln Ile Phe Thr Glu Val Glu Met Thr Thr Leu Glu Lys Val Ile Asn 
785                 790                 795                 800 


Glu Thr Trp Ala Trp Lys Asn Ala Thr Leu Ala Glu Gln Ala Lys Leu 
                805                 810                 815     


Pro Ala Thr Glu Lys Pro Val Leu Leu Ser Lys Asp Ile Glu Ala Lys 
            820                 825                 830         


Met Met Ala Leu Asp Arg Glu Val Gln Tyr Leu Leu Asn Lys Ala Lys 
        835                 840                 845             


Phe Thr Lys Pro Arg Pro Arg Pro Lys Asp Lys Asn Gly Thr Arg Ala 
    850                 855                 860                 


Glu Pro Pro Leu Asn Ala Ser Ala Ser Asp Gln Gly Glu Lys Val Ile 
865                 870                 875                 880 


Pro Pro Ala Gly Gln Thr Glu Asp Ala Glu Pro Ile Ser Glu Pro Glu 
                885                 890                 895     


Lys Val Glu Thr Gly Ser Glu Pro Gly Asp Thr Glu Pro Leu Glu Leu 
            900                 905                 910         


Gly Gly Pro Gly Ala Glu Pro Glu Gln Lys Glu Gln Ser Thr Gly Gln 
        915                 920                 925             


Lys Arg Pro Leu Lys Asn Asp Glu Leu 
    930                 935         


<210>  6671
<211>  147
<212>  PRT
<213>  Homo Sapiens

<400>  6671

Met Ala Asp Lys Val Arg Arg Gln Arg Pro Arg Arg Arg Val Cys Trp 
1               5                   10                  15      


Ala Leu Val Ala Val Leu Leu Ala Asp Leu Leu Ala Leu Ser Asp Thr 
            20                  25                  30          


Leu Ala Val Met Ser Val Asp Leu Gly Ser Glu Ser Met Lys Val Ala 
        35                  40                  45              


Ile Val Lys Pro Gly Val Pro Met Glu Ile Val Leu Asn Lys Glu Ser 
    50                  55                  60                  


Arg Arg Lys Thr Pro Val Ile Val Thr Leu Lys Glu Asn Glu Arg Phe 
65                  70                  75                  80  


Phe Gly Asp Ser Ala Ala Ser Met Ala Ile Lys Asn Pro Lys Ala Thr 
                85                  90                  95      


Leu Arg Tyr Phe Gln His Leu Leu Gly Lys Gln Ala Asp Asn Pro His 
            100                 105                 110         


Val Ala Leu Tyr Gln Ala Arg Phe Pro Glu His Glu Leu Thr Phe Asp 
        115                 120                 125             


Pro Gln Arg Gln Thr Val His Phe Gln Ile Ser Ser Gln Leu Gln Phe 
    130                 135                 140                 


Ser Pro Leu 
145         


<210>  6672
<211>  38
<212>  PRT
<213>  Homo Sapiens

<400>  6672

Met Ala Asp Lys Val Arg Arg Gln Arg Pro Arg Arg Arg Val Cys Trp 
1               5                   10                  15      


Ala Leu Val Ala Val Leu Leu Ala Asp Leu Leu Ala Leu Ser Gly Asn 
            20                  25                  30          


Leu Gly Gly Lys His Arg 
        35              


<210>  6673
<211>  38
<212>  PRT
<213>  Homo Sapiens

<400>  6673

Met Ala Asp Lys Val Arg Arg Gln Arg Pro Arg Arg Arg Val Cys Trp 
1               5                   10                  15      


Ala Leu Val Ala Val Leu Leu Ala Asp Leu Leu Ala Leu Ser Gly Asn 
            20                  25                  30          


Leu Gly Gly Lys His Arg 
        35              


<210>  6674
<211>  79
<212>  PRT
<213>  Homo Sapiens

<400>  6674

Met Gly Ile Leu Lys Leu Gln Val Phe Leu Ile Val Leu Ser Val Ala 
1               5                   10                  15      


Leu Asn His Leu Lys Ala Thr Pro Ile Glu Arg Gln Glu Trp Ile Ile 
            20                  25                  30          


Pro Val Leu Ser Arg Asn Ile Leu Leu Glu Leu Arg Gly Ala Lys Pro 
        35                  40                  45              


Glu His Glu Ala Gly Lys Lys Ser Lys Val Ile Arg Trp Lys Ser Gly 
    50                  55                  60                  


Asn Ala Thr Leu Pro His Val Gln Arg Ser Ala Trp Gln Ile Phe 
65                  70                  75                  


<210>  6675
<211>  79
<212>  PRT
<213>  Homo Sapiens

<400>  6675

Met Gly Ile Leu Lys Leu Gln Val Phe Leu Ile Val Leu Ser Val Ala 
1               5                   10                  15      


Leu Asn His Leu Lys Ala Thr Pro Ile Glu Ser His Gln Val Glu Lys 
            20                  25                  30          


Arg Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe 
        35                  40                  45              


Leu Val His Ser Ser Asn Asn Phe Gly Ala Ile Leu Ser Ser Thr Asn 
    50                  55                  60                  


Val Gly Ser Asn Thr Tyr Gly Lys Arg Asn Ala Val Glu Val Leu 
65                  70                  75                  


<210>  6676
<211>  89
<212>  PRT
<213>  Homo Sapiens

<400>  6676

Met Gly Ile Leu Lys Leu Gln Val Phe Leu Ile Val Leu Ser Val Ala 
1               5                   10                  15      


Leu Asn His Leu Lys Ala Thr Pro Ile Glu Ser His Gln Val Glu Lys 
            20                  25                  30          


Arg Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe 
        35                  40                  45              


Leu Val His Ser Ser Asn Asn Phe Gly Ala Ile Leu Ser Ser Thr Asn 
    50                  55                  60                  


Val Gly Ser Asn Thr Tyr Gly Lys Arg Asn Ala Val Glu Val Leu Lys 
65                  70                  75                  80  


Arg Glu Pro Leu Asn Tyr Leu Pro Leu 
                85                  


<210>  6677
<211>  89
<212>  PRT
<213>  Homo Sapiens

<400>  6677

Met Gly Ile Leu Lys Leu Gln Val Phe Leu Ile Val Leu Ser Val Ala 
1               5                   10                  15      


Leu Asn His Leu Lys Ala Thr Pro Ile Glu Ser His Gln Val Glu Lys 
            20                  25                  30          


Arg Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe 
        35                  40                  45              


Leu Val His Ser Ser Asn Asn Phe Gly Ala Ile Leu Ser Ser Thr Asn 
    50                  55                  60                  


Val Gly Ser Asn Thr Tyr Gly Lys Arg Asn Ala Val Glu Val Leu Lys 
65                  70                  75                  80  


Arg Glu Pro Leu Asn Tyr Leu Pro Leu 
                85                  


<210>  6678
<211>  85
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6678

Xaa Leu Lys Ala Thr Pro Ile Glu Arg Cys Leu Asp Gln Ile Pro Ile 
1               5                   10                  15      


Phe Thr Val Phe Gln Glu Asn His Gln Val Glu Lys Arg Lys Cys Asn 
            20                  25                  30          


Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Ser 
        35                  40                  45              


Ser Asn Asn Phe Gly Ala Ile Leu Ser Ser Thr Asn Val Gly Ser Asn 
    50                  55                  60                  


Thr Tyr Gly Lys Arg Asn Ala Val Glu Val Leu Lys Arg Glu Pro Leu 
65                  70                  75                  80  


Asn Tyr Leu Pro Leu 
                85  


<210>  6679
<211>  317
<212>  PRT
<213>  Homo Sapiens

<400>  6679

Met Lys Thr Ala Leu Ile Leu Leu Ser Ile Leu Gly Met Ala Cys Ala 
1               5                   10                  15      


Phe Ser Met Lys Asn Leu His Arg Arg Val Lys Ile Glu Asp Ser Glu 
            20                  25                  30          


Glu Asn Gly Val Phe Lys Tyr Arg Pro Arg Tyr Tyr Leu Tyr Lys His 
        35                  40                  45              


Ala Tyr Phe Tyr Pro His Leu Lys Arg Phe Pro Val Gln Gly Ser Ser 
    50                  55                  60                  


Asp Ser Ser Glu Glu Asn Gly Asp Asp Ser Ser Glu Glu Glu Glu Glu 
65                  70                  75                  80  


Glu Glu Glu Thr Ser Asn Glu Gly Glu Asn Asn Glu Glu Ser Asn Glu 
                85                  90                  95      


Asp Glu Asp Ser Glu Ala Glu Asn Thr Thr Leu Ser Ala Thr Thr Leu 
            100                 105                 110         


Gly Tyr Gly Glu Asp Ala Thr Pro Gly Thr Gly Tyr Thr Gly Leu Ala 
        115                 120                 125             


Ala Ile Gln Leu Pro Lys Lys Ala Gly Asp Ile Thr Asn Lys Ala Thr 
    130                 135                 140                 


Lys Glu Lys Glu Ser Asp Glu Glu Glu Glu Glu Glu Glu Glu Gly Asn 
145                 150                 155                 160 


Glu Asn Glu Glu Ser Glu Ala Glu Val Asp Glu Asn Glu Gln Gly Ile 
                165                 170                 175     


Asn Gly Thr Ser Thr Asn Ser Thr Glu Ala Glu Asn Gly Asn Gly Ser 
            180                 185                 190         


Ser Gly Gly Asp Asn Gly Glu Glu Gly Glu Glu Glu Ser Val Thr Gly 
        195                 200                 205             


Ala Asn Ala Glu Asp Thr Thr Glu Thr Gly Arg Gln Gly Lys Gly Thr 
    210                 215                 220                 


Ser Lys Thr Thr Thr Ser Pro Asn Gly Gly Phe Glu Pro Thr Thr Pro 
225                 230                 235                 240 


Pro Gln Val Tyr Arg Thr Thr Ser Pro Pro Phe Gly Lys Thr Thr Thr 
                245                 250                 255     


Val Glu Tyr Glu Gly Glu Tyr Glu Tyr Thr Gly Ala Asn Glu Tyr Asp 
            260                 265                 270         


Asn Gly Tyr Glu Ile Tyr Glu Ser Glu Asn Gly Glu Pro Arg Gly Asp 
        275                 280                 285             


Asn Tyr Arg Ala Tyr Glu Asp Glu Tyr Ser Tyr Phe Lys Gly Gln Gly 
    290                 295                 300                 


Tyr Asp Gly Tyr Asp Gly Gln Asn Tyr Tyr His His Gln 
305                 310                 315         


<210>  6680
<211>  180
<212>  PRT
<213>  Homo Sapiens

<400>  6680

Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu 
1               5                   10                  15      


Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser 
            20                  25                  30          


Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys 
        35                  40                  45              


Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu 
    50                  55                  60                  


Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu 
65                  70                  75                  80  


Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys 
                85                  90                  95      


Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr 
            100                 105                 110         


Pro Glu Arg Val Glu Gly Gly Ala Pro Arg Ala Asn Leu Thr Val Val 
        115                 120                 125             


Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu Pro Ala Val Gly Glu 
    130                 135                 140                 


Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg Arg Asp His His Gly 
145                 150                 155                 160 


Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu Arg Pro Gln Gly Leu 
                165                 170                 175     


Glu Leu Phe Glu 
            180 


<210>  6681
<211>  532
<212>  PRT
<213>  Homo Sapiens

<400>  6681

Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu 
1               5                   10                  15      


Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser 
            20                  25                  30          


Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys 
        35                  40                  45              


Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu 
    50                  55                  60                  


Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu 
65                  70                  75                  80  


Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys 
                85                  90                  95      


Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr 
            100                 105                 110         


Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly 
        115                 120                 125             


Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala 
    130                 135                 140                 


Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu 
145                 150                 155                 160 


Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg 
                165                 170                 175     


Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu 
            180                 185                 190         


Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln 
        195                 200                 205             


Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro 
    210                 215                 220                 


Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp 
225                 230                 235                 240 


Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp 
                245                 250                 255     


Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala 
            260                 265                 270         


Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu 
        275                 280                 285             


Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr 
    290                 295                 300                 


Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro 
305                 310                 315                 320 


Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro 
                325                 330                 335     


Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro 
            340                 345                 350         


Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser 
        355                 360                 365             


Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys 
    370                 375                 380                 


Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu 
385                 390                 395                 400 


Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr 
                405                 410                 415     


Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu 
            420                 425                 430         


Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr 
        435                 440                 445             


Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly 
    450                 455                 460                 


Glu Val Thr Arg Lys Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu 
465                 470                 475                 480 


Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala 
                485                 490                 495     


Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr 
            500                 505                 510         


Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln 
        515                 520                 525             


Ala Thr Pro Pro 
    530         


<210>  6682
<211>  310
<212>  PRT
<213>  Homo Sapiens

<400>  6682

Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu 
1               5                   10                  15      


Leu Gly Ala Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu 
            20                  25                  30          


Gly Asp Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe 
        35                  40                  45              


Ser Ala Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln 
    50                  55                  60                  


Arg Leu Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu 
65                  70                  75                  80  


Gln Thr Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr 
                85                  90                  95      


Lys Pro Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala 
            100                 105                 110         


His Pro Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu 
        115                 120                 125             


Gly Pro Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly 
    130                 135                 140                 


Arg Ser Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile 
145                 150                 155                 160 


His Lys Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu 
                165                 170                 175     


Asp Glu Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln 
            180                 185                 190         


Gln Thr Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys 
        195                 200                 205             


Cys Leu Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr 
    210                 215                 220                 


Val Thr Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr 
225                 230                 235                 240 


Gln Gly Glu Val Thr Arg Lys Val Thr Val Asn Val Leu Ser Pro Arg 
                245                 250                 255     


Tyr Glu Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly 
            260                 265                 270         


Thr Ala Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys 
        275                 280                 285             


Lys Tyr Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn 
    290                 295                 300                 


Thr Gln Ala Thr Pro Pro 
305                 310 


<210>  6683
<211>  174
<212>  PRT
<213>  Homo Sapiens

<400>  6683

Met Asn Ser Asn Val Ser Val Tyr Gln Pro Pro Arg Gln Val Ile Leu 
1               5                   10                  15      


Thr Leu Gln Pro Thr Leu Val Ala Val Gly Lys Ser Phe Thr Ile Glu 
            20                  25                  30          


Cys Arg Val Pro Thr Val Glu Pro Leu Asp Ser Leu Thr Leu Phe Leu 
        35                  40                  45              


Phe Arg Gly Asn Glu Thr Leu His Tyr Glu Thr Phe Gly Lys Ala Ala 
    50                  55                  60                  


Pro Ala Pro Gln Glu Ala Thr Ala Thr Phe Asn Ser Thr Ala Asp Arg 
65                  70                  75                  80  


Glu Asp Gly His Arg Asn Phe Ser Cys Leu Ala Val Leu Asp Leu Met 
                85                  90                  95      


Ser Arg Gly Gly Asn Ile Phe His Lys His Ser Ala Pro Lys Met Leu 
            100                 105                 110         


Glu Ile Tyr Glu Pro Val Ser Asp Ser Gln Met Val Ile Ile Val Thr 
        115                 120                 125             


Val Val Ser Val Leu Leu Ser Leu Phe Val Thr Ser Val Leu Leu Cys 
    130                 135                 140                 


Phe Ile Phe Gly Gln His Leu Arg Gln Gln Arg Met Gly Thr Tyr Gly 
145                 150                 155                 160 


Val Arg Ala Ala Trp Arg Arg Leu Pro Gln Ala Phe Arg Pro 
                165                 170                 


<210>  6684
<211>  251
<212>  PRT
<213>  Homo Sapiens

<400>  6684

Met Ser Ser Phe Gly Tyr Arg Thr Leu Thr Val Ala Leu Phe Thr Leu 
1               5                   10                  15      


Ile Cys Cys Pro Gly Ser Asp Glu Lys Val Phe Glu Val His Val Arg 
            20                  25                  30          


Pro Lys Lys Leu Ala Thr Ser Leu Asp Lys Ile Leu Leu Asp Glu Gln 
        35                  40                  45              


Ala Gln Trp Lys His Tyr Leu Val Ser Asn Ile Ser His Asp Thr Val 
    50                  55                  60                  


Leu Gln Cys His Phe Thr Cys Ser Gly Lys Gln Glu Ser Met Asn Ser 
65                  70                  75                  80  


Asn Val Ser Val Tyr Gln Pro Pro Arg Gln Val Ile Leu Thr Leu Gln 
                85                  90                  95      


Pro Thr Leu Val Ala Val Gly Lys Ser Phe Thr Ile Glu Cys Arg Val 
            100                 105                 110         


Pro Thr Val Glu Pro Leu Asp Ser Leu Thr Leu Phe Leu Phe Arg Gly 
        115                 120                 125             


Asn Glu Thr Leu His Tyr Glu Thr Phe Gly Lys Ala Ala Pro Ala Pro 
    130                 135                 140                 


Gln Glu Ala Thr Ala Thr Phe Asn Ser Thr Ala Asp Arg Glu Asp Gly 
145                 150                 155                 160 


His Arg Asn Phe Ser Cys Leu Ala Val Leu Asp Leu Met Ser Arg Gly 
                165                 170                 175     


Gly Asn Ile Phe His Lys His Ser Ala Pro Lys Met Leu Glu Ile Tyr 
            180                 185                 190         


Glu Pro Val Ser Asp Ser Gln Met Val Ile Ile Val Thr Val Val Ser 
        195                 200                 205             


Val Leu Leu Ser Leu Phe Val Thr Ser Val Leu Leu Cys Phe Ile Phe 
    210                 215                 220                 


Gly Gln His Leu Arg Gln Gln Arg Met Gly Thr Tyr Gly Val Arg Ala 
225                 230                 235                 240 


Ala Trp Arg Arg Leu Pro Gln Ala Phe Arg Pro 
                245                 250     


<210>  6685
<211>  167
<212>  PRT
<213>  Homo Sapiens

<400>  6685

Met Ser Ser Phe Gly Tyr Arg Thr Leu Thr Val Ala Leu Phe Thr Leu 
1               5                   10                  15      


Ile Cys Cys Pro Gly Ser Asp Glu Lys Val Phe Glu Val His Val Arg 
            20                  25                  30          


Pro Lys Lys Leu Ala Val Glu Pro Lys Gly Ser Leu Glu Val Asn Cys 
        35                  40                  45              


Ser Thr Thr Cys Asn Gln Pro Glu Val Gly Gly Leu Glu Thr Ser Leu 
    50                  55                  60                  


Asp Lys Ile Leu Leu Asp Glu Gln Ala Gln Trp Lys His Tyr Leu Val 
65                  70                  75                  80  


Ser Asn Ile Ser His Asp Thr Val Leu Gln Cys His Phe Thr Cys Ser 
                85                  90                  95      


Gly Lys Gln Glu Ser Met Asn Ser Asn Val Ser Val Tyr Gln Pro Pro 
            100                 105                 110         


Arg Gln Val Ile Leu Thr Leu Gln Pro Thr Leu Val Ala Val Gly Lys 
        115                 120                 125             


Ser Phe Thr Ile Glu Cys Arg Val Pro Thr Val Glu Pro Leu Asp Ser 
    130                 135                 140                 


Leu Thr Leu Phe Leu Phe Arg Gly Asn Glu Thr Leu His Tyr Glu Thr 
145                 150                 155                 160 


Phe Gly Lys Ala Ala Pro Ala 
                165         


<210>  6686
<211>  214
<212>  PRT
<213>  Homo Sapiens

<400>  6686

Met Ser Ser Phe Gly Tyr Arg Thr Leu Thr Val Ala Leu Phe Thr Leu 
1               5                   10                  15      


Ile Cys Cys Pro Gly Ser Asp Glu Lys Val Phe Glu Val His Val Arg 
            20                  25                  30          


Pro Lys Lys Leu Ala Val Glu Pro Lys Gly Ser Leu Glu Val Asn Cys 
        35                  40                  45              


Ser Thr Thr Cys Asn Gln Pro Glu Val Gly Gly Leu Glu Thr Ser Leu 
    50                  55                  60                  


Asp Lys Ile Leu Leu Asp Glu Gln Ala Gln Trp Lys His Tyr Leu Val 
65                  70                  75                  80  


Ser Asn Ile Ser His Asp Thr Val Leu Gln Cys His Phe Thr Cys Ser 
                85                  90                  95      


Gly Lys Gln Glu Ser Met Asn Ser Asn Val Ser Val Tyr Gln Pro Pro 
            100                 105                 110         


Arg Gln Val Ile Leu Thr Leu Gln Pro Thr Leu Val Ala Val Gly Lys 
        115                 120                 125             


Ser Phe Thr Ile Glu Cys Arg Val Pro Thr Val Glu Pro Leu Asp Ser 
    130                 135                 140                 


Leu Thr Leu Phe Leu Phe Arg Gly Asn Glu Thr Leu His Tyr Glu Thr 
145                 150                 155                 160 


Phe Gly Lys Ala Ala Pro Ala Pro Gln Glu Ala Thr Ala Thr Phe Asn 
                165                 170                 175     


Ser Thr Ala Asp Arg Glu Asp Gly His Arg Asn Phe Ser Cys Leu Ala 
            180                 185                 190         


Val Leu Asp Leu Met Ser Arg Gly Gly Asn Ile Phe His Lys His Ser 
        195                 200                 205             


Ala Pro Lys Met Leu Glu 
    210                 


<210>  6687
<211>  216
<212>  PRT
<213>  Homo Sapiens

<400>  6687

Met Ser Ser Phe Gly Tyr Arg Thr Leu Thr Val Ala Leu Phe Thr Leu 
1               5                   10                  15      


Ile Cys Cys Pro Gly Ser Asp Glu Lys Val Phe Glu Val His Val Arg 
            20                  25                  30          


Pro Lys Lys Leu Ala Val Glu Pro Lys Gly Ser Leu Glu Val Asn Cys 
        35                  40                  45              


Ser Thr Thr Cys Asn Gln Pro Glu Val Gly Gly Leu Glu Thr Ser Leu 
    50                  55                  60                  


Asp Lys Ile Leu Leu Asp Glu Gln Ala Gln Trp Lys His Tyr Leu Val 
65                  70                  75                  80  


Ser Asn Ile Ser His Asp Thr Val Leu Gln Cys His Phe Thr Cys Ser 
                85                  90                  95      


Gly Lys Gln Glu Ser Met Asn Ser Asn Val Ser Val Tyr Gln Pro Pro 
            100                 105                 110         


Arg Gln Val Ile Leu Thr Leu Gln Pro Thr Leu Val Ala Val Gly Lys 
        115                 120                 125             


Ser Phe Thr Ile Glu Cys Arg Val Pro Thr Val Glu Pro Leu Asp Ser 
    130                 135                 140                 


Leu Thr Leu Phe Leu Phe Arg Gly Asn Glu Thr Leu His Tyr Glu Thr 
145                 150                 155                 160 


Phe Gly Lys Ala Ala Pro Ala Pro Gln Glu Ala Thr Ala Thr Phe Asn 
                165                 170                 175     


Ser Thr Ala Asp Arg Glu Asp Gly His Arg Asn Phe Ser Cys Leu Ala 
            180                 185                 190         


Val Leu Asp Leu Met Ser Arg Gly Gly Asn Ile Phe His Lys His Ser 
        195                 200                 205             


Ala Pro Lys Met Leu Glu Ile Tyr 
    210                 215     


<210>  6688
<211>  275
<212>  PRT
<213>  Homo Sapiens

<400>  6688

Met Ser Ser Phe Gly Tyr Arg Thr Leu Thr Val Ala Leu Phe Thr Leu 
1               5                   10                  15      


Ile Cys Cys Pro Gly Ser Asp Glu Lys Val Phe Glu Val His Val Arg 
            20                  25                  30          


Pro Lys Lys Leu Ala Val Glu Pro Lys Gly Ser Leu Glu Val Asn Cys 
        35                  40                  45              


Ser Thr Thr Cys Asn Gln Pro Glu Val Gly Gly Leu Glu Thr Ser Leu 
    50                  55                  60                  


Asp Lys Ile Leu Leu Asp Glu Gln Ala Gln Trp Lys His Tyr Leu Val 
65                  70                  75                  80  


Ser Asn Ile Ser His Asp Thr Val Leu Gln Cys His Phe Thr Cys Ser 
                85                  90                  95      


Gly Lys Gln Glu Ser Met Asn Ser Asn Val Ser Val Tyr Gln Pro Pro 
            100                 105                 110         


Arg Gln Val Ile Leu Thr Leu Gln Pro Thr Leu Val Ala Val Gly Lys 
        115                 120                 125             


Ser Phe Thr Ile Glu Cys Arg Val Pro Thr Val Glu Pro Leu Asp Ser 
    130                 135                 140                 


Leu Thr Leu Phe Leu Phe Arg Gly Asn Glu Thr Leu His Tyr Glu Thr 
145                 150                 155                 160 


Phe Gly Lys Ala Ala Pro Ala Pro Gln Glu Ala Thr Ala Thr Phe Asn 
                165                 170                 175     


Ser Thr Ala Asp Arg Glu Asp Gly His Arg Asn Phe Ser Cys Leu Ala 
            180                 185                 190         


Val Leu Asp Leu Met Ser Arg Gly Gly Asn Ile Phe His Lys His Ser 
        195                 200                 205             


Ala Pro Lys Met Leu Glu Ile Tyr Glu Pro Val Ser Asp Ser Gln Met 
    210                 215                 220                 


Val Ile Ile Val Thr Val Val Ser Val Leu Leu Ser Leu Phe Val Thr 
225                 230                 235                 240 


Ser Val Leu Leu Cys Phe Ile Phe Gly Gln His Leu Arg Gln Gln Arg 
                245                 250                 255     


Met Gly Thr Tyr Gly Val Arg Ala Ala Trp Arg Arg Leu Pro Gln Ala 
            260                 265                 270         


Phe Arg Pro 
        275 


<210>  6689
<211>  275
<212>  PRT
<213>  Homo Sapiens

<400>  6689

Met Ser Ser Phe Gly Tyr Arg Thr Leu Thr Val Ala Leu Phe Thr Leu 
1               5                   10                  15      


Ile Cys Cys Pro Gly Ser Asp Glu Lys Val Phe Glu Val His Val Arg 
            20                  25                  30          


Pro Lys Lys Leu Ala Val Glu Pro Lys Gly Ser Leu Glu Val Asn Cys 
        35                  40                  45              


Ser Thr Thr Cys Asn Gln Pro Glu Val Gly Gly Leu Glu Thr Ser Leu 
    50                  55                  60                  


Asp Lys Ile Leu Leu Asp Glu Gln Ala Gln Trp Lys His Tyr Leu Val 
65                  70                  75                  80  


Ser Asn Ile Ser His Asp Thr Val Leu Gln Cys His Phe Thr Cys Ser 
                85                  90                  95      


Gly Lys Gln Glu Ser Met Asn Ser Asn Val Ser Val Tyr Gln Pro Pro 
            100                 105                 110         


Arg Gln Val Ile Leu Thr Leu Gln Pro Thr Leu Val Ala Val Gly Lys 
        115                 120                 125             


Ser Phe Thr Ile Glu Cys Arg Val Pro Thr Val Glu Pro Leu Asp Ser 
    130                 135                 140                 


Leu Thr Leu Phe Leu Phe Arg Gly Asn Glu Thr Leu His Tyr Glu Thr 
145                 150                 155                 160 


Phe Gly Lys Ala Ala Pro Ala Pro Gln Glu Ala Thr Ala Thr Phe Asn 
                165                 170                 175     


Ser Thr Ala Asp Arg Glu Asp Gly His Arg Asn Phe Ser Cys Leu Ala 
            180                 185                 190         


Val Leu Asp Leu Met Ser Arg Gly Gly Asn Ile Phe His Lys His Ser 
        195                 200                 205             


Ala Pro Lys Met Leu Glu Ile Tyr Glu Pro Val Ser Asp Ser Gln Met 
    210                 215                 220                 


Val Ile Ile Val Thr Val Val Ser Val Leu Leu Ser Leu Phe Val Thr 
225                 230                 235                 240 


Ser Val Leu Leu Cys Phe Ile Phe Gly Gln His Leu Arg Gln Gln Arg 
                245                 250                 255     


Met Gly Thr Tyr Gly Val Arg Ala Ala Trp Arg Arg Leu Pro Gln Ala 
            260                 265                 270         


Phe Arg Pro 
        275 


<210>  6690
<211>  275
<212>  PRT
<213>  Homo Sapiens

<400>  6690

Met Ser Ser Phe Gly Tyr Arg Thr Leu Thr Val Ala Leu Phe Thr Leu 
1               5                   10                  15      


Ile Cys Cys Pro Gly Ser Asp Glu Lys Val Phe Glu Val His Val Arg 
            20                  25                  30          


Pro Lys Lys Leu Ala Val Glu Pro Lys Gly Ser Leu Glu Val Asn Cys 
        35                  40                  45              


Ser Thr Thr Cys Asn Gln Pro Glu Val Gly Gly Leu Glu Thr Ser Leu 
    50                  55                  60                  


Asp Lys Ile Leu Leu Asp Glu Gln Ala Gln Trp Lys His Tyr Leu Val 
65                  70                  75                  80  


Ser Asn Ile Ser His Asp Thr Val Leu Gln Cys His Phe Thr Cys Ser 
                85                  90                  95      


Gly Lys Gln Glu Ser Met Asn Ser Asn Val Ser Val Tyr Gln Pro Pro 
            100                 105                 110         


Arg Gln Val Ile Leu Thr Leu Gln Pro Thr Leu Val Ala Val Gly Lys 
        115                 120                 125             


Ser Phe Thr Ile Glu Cys Arg Val Pro Thr Val Glu Pro Leu Asp Ser 
    130                 135                 140                 


Leu Thr Leu Phe Leu Phe Arg Gly Asn Glu Thr Leu His Tyr Glu Thr 
145                 150                 155                 160 


Phe Gly Lys Ala Ala Pro Ala Pro Gln Glu Ala Thr Ala Thr Phe Asn 
                165                 170                 175     


Ser Thr Ala Asp Arg Glu Asp Gly His Arg Asn Phe Ser Cys Leu Ala 
            180                 185                 190         


Val Leu Asp Leu Met Ser Arg Gly Gly Asn Ile Phe His Lys His Ser 
        195                 200                 205             


Ala Pro Lys Met Leu Glu Ile Tyr Glu Pro Val Ser Asp Ser Gln Met 
    210                 215                 220                 


Val Ile Ile Val Thr Val Val Ser Val Leu Leu Ser Leu Phe Val Thr 
225                 230                 235                 240 


Ser Val Leu Leu Cys Phe Ile Phe Gly Gln His Leu Arg Gln Gln Arg 
                245                 250                 255     


Met Gly Thr Tyr Gly Val Arg Ala Ala Trp Arg Arg Leu Pro Gln Ala 
            260                 265                 270         


Phe Arg Pro 
        275 


<210>  6691
<211>  275
<212>  PRT
<213>  Homo Sapiens

<400>  6691

Met Ser Ser Phe Gly Tyr Arg Thr Leu Thr Val Ala Leu Phe Thr Leu 
1               5                   10                  15      


Ile Cys Cys Pro Gly Ser Asp Glu Lys Val Phe Glu Val His Val Arg 
            20                  25                  30          


Pro Lys Lys Leu Ala Val Glu Pro Lys Gly Ser Leu Glu Val Asn Cys 
        35                  40                  45              


Ser Thr Thr Cys Asn Gln Pro Glu Val Gly Gly Leu Glu Thr Ser Leu 
    50                  55                  60                  


Asp Lys Ile Leu Leu Asp Glu Gln Ala Gln Trp Lys His Tyr Leu Val 
65                  70                  75                  80  


Ser Asn Ile Ser His Asp Thr Val Leu Gln Cys His Phe Thr Cys Ser 
                85                  90                  95      


Gly Lys Gln Glu Ser Met Asn Ser Asn Val Ser Val Tyr Gln Pro Pro 
            100                 105                 110         


Arg Gln Val Ile Leu Thr Leu Gln Pro Thr Leu Val Ala Val Gly Lys 
        115                 120                 125             


Ser Phe Thr Ile Glu Cys Arg Val Pro Thr Val Glu Pro Leu Asp Ser 
    130                 135                 140                 


Leu Thr Leu Phe Leu Phe Arg Gly Asn Glu Thr Leu His Tyr Glu Thr 
145                 150                 155                 160 


Phe Gly Lys Ala Ala Pro Ala Pro Gln Glu Ala Thr Ala Thr Phe Asn 
                165                 170                 175     


Ser Thr Ala Asp Arg Glu Asp Gly His Arg Asn Phe Ser Cys Leu Ala 
            180                 185                 190         


Val Leu Asp Leu Met Ser Arg Gly Gly Asn Ile Phe His Lys His Ser 
        195                 200                 205             


Ala Pro Lys Met Leu Glu Ile Tyr Glu Pro Val Ser Asp Ser Gln Met 
    210                 215                 220                 


Val Ile Ile Val Thr Val Val Ser Val Leu Leu Ser Leu Phe Val Thr 
225                 230                 235                 240 


Ser Val Leu Leu Cys Phe Ile Phe Gly Gln His Leu Arg Gln Gln Arg 
                245                 250                 255     


Met Gly Thr Tyr Gly Val Arg Ala Ala Trp Arg Arg Leu Pro Gln Ala 
            260                 265                 270         


Phe Arg Pro 
        275 


<210>  6692
<211>  275
<212>  PRT
<213>  Homo Sapiens

<400>  6692

Met Ser Ser Phe Gly Tyr Arg Thr Leu Thr Val Ala Leu Phe Thr Leu 
1               5                   10                  15      


Ile Cys Cys Pro Gly Ser Asp Glu Lys Val Phe Glu Val His Val Arg 
            20                  25                  30          


Pro Lys Lys Leu Ala Val Glu Pro Lys Gly Ser Leu Glu Val Asn Cys 
        35                  40                  45              


Ser Thr Thr Cys Asn Gln Pro Glu Val Gly Gly Leu Glu Thr Ser Leu 
    50                  55                  60                  


Asp Lys Ile Leu Leu Asp Glu Gln Ala Gln Trp Lys His Tyr Leu Val 
65                  70                  75                  80  


Ser Asn Ile Ser His Asp Thr Val Leu Gln Cys His Phe Thr Cys Ser 
                85                  90                  95      


Gly Lys Gln Glu Ser Met Asn Ser Asn Val Ser Val Tyr Gln Pro Pro 
            100                 105                 110         


Arg Gln Val Ile Leu Thr Leu Gln Pro Thr Leu Val Ala Val Gly Lys 
        115                 120                 125             


Ser Phe Thr Ile Glu Cys Arg Val Pro Thr Val Glu Pro Leu Asp Ser 
    130                 135                 140                 


Leu Thr Leu Phe Leu Phe Arg Gly Asn Glu Thr Leu His Tyr Glu Thr 
145                 150                 155                 160 


Phe Gly Lys Ala Ala Pro Ala Pro Gln Glu Ala Thr Ala Thr Phe Asn 
                165                 170                 175     


Ser Thr Ala Asp Arg Glu Asp Gly His Arg Asn Phe Ser Cys Leu Ala 
            180                 185                 190         


Val Leu Asp Leu Met Ser Arg Gly Gly Asn Ile Phe His Lys His Ser 
        195                 200                 205             


Ala Pro Lys Met Leu Glu Ile Tyr Glu Pro Val Ser Asp Ser Gln Met 
    210                 215                 220                 


Val Ile Ile Val Thr Val Val Ser Val Leu Leu Ser Leu Phe Val Thr 
225                 230                 235                 240 


Ser Val Leu Leu Cys Phe Ile Phe Gly Gln His Leu Arg Gln Gln Arg 
                245                 250                 255     


Met Gly Thr Tyr Gly Val Arg Ala Ala Trp Arg Arg Leu Pro Gln Ala 
            260                 265                 270         


Phe Arg Pro 
        275 


<210>  6693
<211>  53
<212>  PRT
<213>  Homo Sapiens

<400>  6693

Met Ser Ser Phe Gly Tyr Arg Thr Leu Thr Val Ala Leu Phe Thr Leu 
1               5                   10                  15      


Ile Cys Cys Pro Gly Val Asn Glu Phe Gln Arg Gln Arg Val Pro Ala 
            20                  25                  30          


Ser Lys Ala Gly His Pro Asp Thr Ala Thr His Phe Gly Gly Cys Gly 
        35                  40                  45              


Gln Val Leu His His 
    50              


<210>  6694
<211>  271
<212>  PRT
<213>  Homo Sapiens

<400>  6694

Met Gly Ser Leu Phe Pro Leu Ser Leu Leu Phe Phe Leu Ala Ala Ala 
1               5                   10                  15      


Tyr Pro Gly Val Gly Ser Ala Leu Gly Arg Arg Thr Lys Arg Ala Gln 
            20                  25                  30          


Ser Pro Lys Gly Ser Pro Leu Ala Pro Ser Gly Thr Ser Val Pro Phe 
        35                  40                  45              


Trp Val Arg Met Ser Pro Glu Phe Val Ala Val Gln Pro Gly Lys Ser 
    50                  55                  60                  


Val Gln Leu Asn Cys Ser Asn Ser Cys Pro Gln Pro Gln Asn Ser Ser 
65                  70                  75                  80  


Leu Arg Thr Pro Leu Arg Gln Gly Lys Thr Leu Arg Gly Pro Gly Trp 
                85                  90                  95      


Val Ser Tyr Gln Leu Leu Asp Val Arg Ala Trp Ser Ser Leu Ala His 
            100                 105                 110         


Cys Leu Val Thr Cys Ala Gly Lys Thr Arg Trp Ala Thr Ser Arg Ile 
        115                 120                 125             


Thr Ala Tyr Lys Pro Pro His Ser Val Ile Leu Glu Pro Pro Val Leu 
    130                 135                 140                 


Lys Gly Arg Lys Tyr Thr Leu Arg Cys His Val Thr Gln Val Phe Pro 
145                 150                 155                 160 


Val Gly Tyr Leu Val Val Thr Leu Arg His Gly Ser Arg Val Ile Tyr 
                165                 170                 175     


Ser Glu Ser Leu Glu Arg Phe Thr Gly Leu Asp Leu Ala Asn Val Thr 
            180                 185                 190         


Leu Thr Tyr Glu Phe Ala Ala Gly Pro Arg Asp Phe Trp Gln Pro Val 
        195                 200                 205             


Ile Cys His Ala Arg Leu Asn Leu Asp Gly Leu Val Val Arg Asn Ser 
    210                 215                 220                 


Ser Ala Pro Ile Thr Leu Met Leu Ala Trp Ser Pro Ala Pro Thr Ala 
225                 230                 235                 240 


Leu Ala Ser Gly Ser Ile Ala Ala Leu Val Gly Ile Leu Leu Thr Val 
                245                 250                 255     


Gly Ala Ala Tyr Leu Cys Lys Cys Leu Ala Met Lys Ser Gln Ala 
            260                 265                 270     


<210>  6695
<211>  237
<212>  PRT
<213>  Homo Sapiens

<400>  6695

Met Gly Ser Leu Phe Pro Leu Ser Leu Leu Phe Phe Leu Ala Ala Ala 
1               5                   10                  15      


Tyr Pro Gly Val Gly Ser Ala Leu Gly Arg Arg Thr Lys Arg Ala Gln 
            20                  25                  30          


Ser Pro Lys Gly Ser Pro Leu Ala Pro Ser Gly Thr Ser Val Pro Phe 
        35                  40                  45              


Trp Val Arg Met Ser Pro Glu Phe Val Ala Val Gln Pro Gly Lys Ser 
    50                  55                  60                  


Val Gln Leu Asn Cys Ser Asn Ser Cys Pro Gln Pro Gln Asn Ser Ser 
65                  70                  75                  80  


Leu Arg Thr Pro Leu Arg Gln Gly Lys Thr Leu Arg Gly Pro Gly Trp 
                85                  90                  95      


Val Ser Tyr Gln Leu Leu Asp Val Arg Ala Trp Ser Ser Leu Ala His 
            100                 105                 110         


Cys Leu Val Thr Cys Ala Gly Lys Thr Arg Trp Ala Thr Ser Arg Ile 
        115                 120                 125             


Thr Ala Tyr Lys Pro Pro His Ser Val Ile Leu Glu Pro Pro Val Leu 
    130                 135                 140                 


Lys Gly Arg Lys Tyr Thr Leu Arg Cys His Val Thr Gln Val Phe Pro 
145                 150                 155                 160 


Val Gly Tyr Leu Val Val Thr Leu Arg His Gly Ser Arg Val Ile Tyr 
                165                 170                 175     


Ser Glu Ser Leu Glu Arg Phe Thr Gly Leu Asp Leu Ala Asn Val Thr 
            180                 185                 190         


Leu Thr Tyr Glu Phe Ala Ala Gly Pro Arg Asp Phe Trp Gln Pro Val 
        195                 200                 205             


Ile Cys His Ala Arg Leu Asn Leu Asp Gly Leu Val Val Arg Asn Ser 
    210                 215                 220                 


Ser Ala Pro Ile Thr Leu Met Leu Gly Glu Ala Pro Leu 
225                 230                 235         


<210>  6696
<211>  272
<212>  PRT
<213>  Homo Sapiens

<400>  6696

Met Gly Ser Leu Phe Pro Leu Ser Leu Leu Phe Phe Leu Ala Ala Ala 
1               5                   10                  15      


Tyr Pro Gly Val Gly Ser Ala Leu Gly Arg Arg Thr Lys Arg Ala Gln 
            20                  25                  30          


Ser Pro Lys Gly Ser Pro Leu Ala Pro Ser Gly Thr Ser Val Pro Phe 
        35                  40                  45              


Trp Val Arg Met Ser Pro Glu Phe Val Ala Val Gln Pro Gly Lys Ser 
    50                  55                  60                  


Val Gln Leu Asn Cys Ser Asn Ser Cys Pro Gln Pro Gln Asn Ser Ser 
65                  70                  75                  80  


Leu Arg Thr Pro Leu Arg Gln Gly Lys Thr Leu Arg Gly Pro Gly Trp 
                85                  90                  95      


Val Ser Tyr Gln Leu Leu Asp Val Arg Ala Trp Ser Ser Leu Ala His 
            100                 105                 110         


Cys Leu Val Thr Cys Ala Gly Lys Thr Arg Trp Ala Thr Ser Arg Ile 
        115                 120                 125             


Thr Ala Tyr Ser Val Pro Gly Gly Leu Leu Gly Gly Asp Pro Glu Ala 
    130                 135                 140                 


Trp Lys Pro Gly His Leu Phe Arg Lys Pro Gly Ala Leu His Arg Pro 
145                 150                 155                 160 


Gly Ser Gly Gln Arg Asp Leu Asp Leu Arg Val Cys Cys Trp Thr Pro 
                165                 170                 175     


Arg Leu Leu Ala Ala Arg Asp Leu Pro Arg Ala Pro Gln Ser Arg Arg 
            180                 185                 190         


Pro Gly Gly Pro Gln Gln Leu Gly Thr His Tyr Thr Asp Ala Arg Leu 
        195                 200                 205             


Glu Pro Arg Ala His Ser Phe Gly Leu Arg Phe His Arg Cys Pro Cys 
    210                 215                 220                 


Arg Asp Pro Pro His Cys Gly Arg Cys Val Pro Met Gln Val Pro Ser 
225                 230                 235                 240 


Tyr Glu Val Pro Gly Val Lys Gly Asp Val Leu Cys Arg Leu Ser Glu 
                245                 250                 255     


Lys Lys Arg Asn Met Lys Gln Ser Gly Glu Met Ala Ile His Gly Gly 
            260                 265                 270         


<210>  6697
<211>  155
<212>  PRT
<213>  Homo Sapiens

<400>  6697

Met Lys Val Ala Ser Gly Ser Thr Ala Thr Ala Ala Ala Gly Pro Ser 
1               5                   10                  15      


Cys Ala Leu Lys Ala Gly Lys Thr Ala Ser Gly Ala Gly Glu Val Val 
            20                  25                  30          


Arg Cys Leu Ser Glu Gln Ser Val Ala Ile Ser Arg Cys Ala Gly Gly 
        35                  40                  45              


Ala Gly Ala Arg Leu Pro Ala Leu Leu Asp Glu Gln Gln Val Asn Val 
    50                  55                  60                  


Leu Leu Tyr Asp Met Asn Gly Cys Tyr Ser Arg Leu Lys Glu Leu Val 
65                  70                  75                  80  


Pro Thr Leu Pro Gln Asn Arg Lys Val Ser Lys Val Glu Ile Leu Gln 
                85                  90                  95      


His Val Ile Asp Tyr Ile Arg Asp Leu Gln Leu Glu Leu Asn Ser Glu 
            100                 105                 110         


Ser Glu Val Gly Thr Pro Gly Gly Arg Gly Leu Pro Val Arg Ala Pro 
        115                 120                 125             


Leu Ser Thr Leu Asn Gly Glu Ile Ser Ala Leu Thr Ala Glu Ala Ala 
    130                 135                 140                 


Cys Val Pro Ala Asp Asp Arg Ile Leu Cys Arg 
145                 150                 155 


<210>  6698
<211>  149
<212>  PRT
<213>  Homo Sapiens

<400>  6698

Met Lys Val Ala Ser Gly Ser Thr Ala Thr Ala Ala Ala Gly Pro Ser 
1               5                   10                  15      


Cys Ala Leu Lys Ala Gly Lys Thr Ala Ser Gly Ala Gly Glu Val Val 
            20                  25                  30          


Arg Cys Leu Ser Glu Gln Ser Val Ala Ile Ser Arg Cys Ala Gly Gly 
        35                  40                  45              


Ala Gly Ala Arg Leu Pro Ala Leu Leu Asp Glu Gln Gln Val Asn Val 
    50                  55                  60                  


Leu Leu Tyr Asp Met Asn Gly Cys Tyr Ser Arg Leu Lys Glu Leu Val 
65                  70                  75                  80  


Pro Thr Leu Pro Gln Asn Arg Lys Val Ser Lys Val Glu Ile Leu Gln 
                85                  90                  95      


His Val Ile Asp Tyr Ile Arg Asp Leu Gln Leu Glu Leu Asn Ser Glu 
            100                 105                 110         


Ser Glu Val Gly Thr Pro Gly Gly Arg Gly Leu Pro Val Arg Ala Pro 
        115                 120                 125             


Leu Ser Thr Leu Asn Gly Glu Ile Ser Ala Leu Thr Ala Glu Val Arg 
    130                 135                 140                 


Ser Arg Ser Asp His 
145                 


<210>  6699
<211>  257
<212>  PRT
<213>  Homo Sapiens

<400>  6699

Glu Phe Ile Ile Arg Gly Gly Arg Val Pro Ser His Cys Leu His Phe 
1               5                   10                  15      


Ser Arg Ser Phe Gln Lys Lys Thr Tyr Ser Lys Met Asn Asn Pro Ala 
            20                  25                  30          


Ile Lys Arg Ile Gly Asn His Ile Thr Lys Ser Pro Glu Asp Lys Arg 
        35                  40                  45              


Glu Tyr Arg Gly Leu Glu Leu Ala Asn Gly Ile Lys Val Leu Leu Ile 
    50                  55                  60                  


Ser Asp Pro Thr Thr Asp Lys Ser Ser Ala Ala Leu Asp Val His Ile 
65                  70                  75                  80  


Gly Ser Leu Ser Asp Pro Pro Asn Ile Ala Gly Leu Ser His Phe Cys 
                85                  90                  95      


Glu His Met Leu Phe Leu Gly Thr Lys Lys Tyr Pro Lys Glu Asn Glu 
            100                 105                 110         


Tyr Ser Gln Phe Leu Ser Glu His Ala Gly Ser Ser Asn Ala Phe Thr 
        115                 120                 125             


Ser Gly Glu His Thr Asn Tyr Tyr Phe Asp Val Ser His Glu His Leu 
    130                 135                 140                 


Glu Gly Ala Leu Asp Arg Phe Ala Gln Phe Phe Leu Cys Pro Leu Phe 
145                 150                 155                 160 


Asp Glu Ser Cys Lys Asp Arg Glu Val Asn Ala Val Asp Ser Glu His 
                165                 170                 175     


Glu Lys Asn Val Met Asn Asp Ala Trp Arg Leu Phe Gln Leu Glu Lys 
            180                 185                 190         


Ala Thr Gly Asn Pro Lys His Pro Phe Ser Lys Phe Gly Thr Gly Asn 
        195                 200                 205             


Lys Tyr Thr Leu Glu Thr Arg Pro Asn Gln Glu Gly Ile Asp Val Arg 
    210                 215                 220                 


Gln Glu Leu Leu Lys Phe His Ser Ala Tyr Tyr Ser Ser Asn Leu Met 
225                 230                 235                 240 


Ala Val Cys Val Leu Gly Arg Glu Ser Leu Asp Asp Leu Thr Asn Leu 
                245                 250                 255     


Val 
    


<210>  6700
<211>  1019
<212>  PRT
<213>  Homo Sapiens

<400>  6700

Met Arg Tyr Arg Leu Ala Trp Leu Leu His Pro Ala Leu Pro Ser Thr 
1               5                   10                  15      


Phe Arg Ser Val Leu Gly Ala Arg Leu Pro Pro Pro Glu Arg Leu Cys 
            20                  25                  30          


Gly Phe Gln Lys Lys Thr Tyr Ser Lys Met Asn Asn Pro Ala Ile Lys 
        35                  40                  45              


Arg Ile Gly Asn His Ile Thr Lys Ser Pro Glu Asp Lys Arg Glu Tyr 
    50                  55                  60                  


Arg Gly Leu Glu Leu Ala Asn Gly Ile Lys Val Leu Leu Ile Ser Asp 
65                  70                  75                  80  


Pro Thr Thr Asp Lys Ser Ser Ala Ala Leu Asp Val His Ile Gly Ser 
                85                  90                  95      


Leu Ser Asp Pro Pro Asn Ile Ala Gly Leu Ser His Phe Cys Glu His 
            100                 105                 110         


Met Leu Phe Leu Gly Thr Lys Lys Tyr Pro Lys Glu Asn Glu Tyr Ser 
        115                 120                 125             


Gln Phe Leu Ser Glu His Ala Gly Ser Ser Asn Ala Phe Thr Ser Gly 
    130                 135                 140                 


Glu His Thr Asn Tyr Tyr Phe Asp Val Ser His Glu His Leu Glu Gly 
145                 150                 155                 160 


Ala Leu Asp Arg Phe Ala Gln Phe Phe Leu Cys Pro Leu Phe Asp Glu 
                165                 170                 175     


Ser Cys Lys Asp Arg Glu Val Asn Ala Val Asp Ser Glu His Glu Lys 
            180                 185                 190         


Asn Val Met Asn Asp Ala Trp Arg Leu Phe Gln Leu Glu Lys Ala Thr 
        195                 200                 205             


Gly Asn Pro Lys His Pro Phe Ser Lys Phe Gly Thr Gly Asn Lys Tyr 
    210                 215                 220                 


Thr Leu Glu Thr Arg Pro Asn Gln Glu Gly Ile Asp Val Arg Gln Glu 
225                 230                 235                 240 


Leu Leu Lys Phe His Ser Ala Tyr Tyr Ser Ser Asn Leu Met Ala Val 
                245                 250                 255     


Cys Val Leu Gly Arg Glu Ser Leu Asp Asp Leu Thr Asn Leu Val Val 
            260                 265                 270         


Lys Leu Phe Ser Glu Val Glu Asn Lys Asn Val Pro Leu Pro Glu Phe 
        275                 280                 285             


Pro Glu His Pro Phe Gln Glu Glu His Leu Lys Gln Leu Tyr Lys Ile 
    290                 295                 300                 


Val Pro Ile Lys Asp Ile Arg Asn Leu Tyr Val Thr Phe Pro Ile Pro 
305                 310                 315                 320 


Asp Leu Gln Lys Tyr Tyr Lys Ser Asn Pro Gly His Tyr Leu Gly His 
                325                 330                 335     


Leu Ile Gly His Glu Gly Pro Gly Ser Leu Leu Ser Glu Leu Lys Ser 
            340                 345                 350         


Lys Gly Trp Val Asn Thr Leu Val Gly Gly Gln Lys Glu Gly Ala Arg 
        355                 360                 365             


Gly Phe Met Phe Phe Ile Ile Asn Val Asp Leu Thr Glu Glu Gly Leu 
    370                 375                 380                 


Leu His Val Glu Asp Ile Ile Leu His Met Phe Gln Tyr Ile Gln Lys 
385                 390                 395                 400 


Leu Arg Ala Glu Gly Pro Gln Glu Trp Val Phe Gln Glu Cys Lys Asp 
                405                 410                 415     


Leu Asn Ala Val Ala Phe Arg Phe Lys Asp Lys Glu Arg Pro Arg Gly 
            420                 425                 430         


Tyr Thr Ser Lys Ile Ala Gly Ile Leu His Tyr Tyr Pro Leu Glu Glu 
        435                 440                 445             


Val Leu Thr Ala Glu Tyr Leu Leu Glu Glu Phe Arg Pro Asp Leu Ile 
    450                 455                 460                 


Glu Met Val Leu Asp Lys Leu Arg Pro Glu Asn Val Arg Val Ala Ile 
465                 470                 475                 480 


Val Ser Lys Ser Phe Glu Gly Lys Thr Asp Arg Thr Glu Glu Trp Tyr 
                485                 490                 495     


Gly Thr Gln Tyr Lys Gln Glu Ala Ile Pro Asp Glu Val Ile Lys Lys 
            500                 505                 510         


Trp Gln Asn Ala Asp Leu Asn Gly Lys Phe Lys Leu Pro Thr Lys Asn 
        515                 520                 525             


Glu Phe Ile Pro Thr Asn Phe Glu Ile Leu Pro Leu Glu Lys Glu Ala 
    530                 535                 540                 


Thr Pro Tyr Pro Ala Leu Ile Lys Asp Thr Ala Met Ser Lys Leu Trp 
545                 550                 555                 560 


Phe Lys Gln Asp Asp Lys Phe Phe Leu Pro Lys Ala Cys Leu Asn Phe 
                565                 570                 575     


Glu Phe Phe Ser Pro Phe Ala Tyr Val Asp Pro Leu His Cys Asn Met 
            580                 585                 590         


Ala Tyr Leu Tyr Leu Glu Leu Leu Lys Asp Ser Leu Asn Glu Tyr Ala 
        595                 600                 605             


Tyr Ala Ala Glu Leu Ala Gly Leu Ser Tyr Asp Leu Gln Asn Thr Ile 
    610                 615                 620                 


Tyr Gly Met Tyr Leu Ser Val Lys Gly Tyr Asn Asp Lys Gln Pro Ile 
625                 630                 635                 640 


Leu Leu Lys Lys Ile Ile Glu Lys Met Ala Thr Phe Glu Ile Asp Glu 
                645                 650                 655     


Lys Arg Phe Glu Ile Ile Lys Glu Ala Tyr Met Arg Ser Leu Asn Asn 
            660                 665                 670         


Phe Arg Ala Glu Gln Pro His Gln His Ala Met Tyr Tyr Leu Arg Leu 
        675                 680                 685             


Leu Met Thr Glu Val Ala Trp Thr Lys Asp Glu Leu Lys Glu Ala Leu 
    690                 695                 700                 


Asp Asp Val Thr Leu Pro Arg Leu Lys Ala Phe Ile Pro Gln Leu Leu 
705                 710                 715                 720 


Ser Arg Leu His Ile Glu Ala Leu Leu His Gly Asn Ile Thr Lys Gln 
                725                 730                 735     


Ala Ala Leu Gly Ile Met Gln Met Val Glu Asp Thr Leu Ile Glu His 
            740                 745                 750         


Ala His Thr Lys Pro Leu Leu Pro Ser Gln Leu Val Arg Tyr Arg Glu 
        755                 760                 765             


Val Gln Leu Pro Asp Arg Gly Trp Phe Val Tyr Gln Gln Arg Asn Glu 
    770                 775                 780                 


Val His Asn Asn Cys Gly Ile Glu Ile Tyr Tyr Gln Thr Asp Met Gln 
785                 790                 795                 800 


Ser Thr Ser Glu Asn Met Phe Leu Glu Leu Phe Cys Gln Ile Ile Ser 
                805                 810                 815     


Glu Pro Cys Phe Asn Thr Leu Arg Thr Lys Glu Gln Leu Gly Tyr Ile 
            820                 825                 830         


Val Phe Ser Gly Pro Arg Arg Ala Asn Gly Ile Gln Gly Leu Arg Phe 
        835                 840                 845             


Ile Ile Gln Ser Glu Lys Pro Pro His Tyr Leu Glu Ser Arg Val Glu 
    850                 855                 860                 


Ala Phe Leu Ile Thr Met Glu Lys Ser Ile Glu Asp Met Thr Glu Glu 
865                 870                 875                 880 


Ala Phe Gln Lys His Ile Gln Ala Leu Ala Ile Arg Arg Leu Asp Lys 
                885                 890                 895     


Pro Lys Lys Leu Ser Ala Glu Cys Ala Lys Tyr Trp Gly Glu Ile Ile 
            900                 905                 910         


Ser Gln Gln Tyr Asn Phe Asp Arg Asp Asn Thr Glu Val Ala Tyr Leu 
        915                 920                 925             


Lys Thr Leu Thr Lys Glu Asp Ile Ile Lys Phe Tyr Lys Glu Met Leu 
    930                 935                 940                 


Ala Val Asp Ala Pro Arg Arg His Lys Val Ser Val His Val Leu Ala 
945                 950                 955                 960 


Arg Glu Met Asp Ser Cys Pro Val Val Gly Glu Phe Pro Cys Gln Asn 
                965                 970                 975     


Asp Ile Asn Leu Ser Gln Ala Pro Ala Leu Pro Gln Pro Glu Val Ile 
            980                 985                 990         


Gln Asn Met Thr Glu Phe Lys Arg  Gly Leu Pro Leu Phe  Pro Leu Val 
        995                 1000                 1005             


Lys Pro  His Ile Asn Phe Met  Ala Ala Lys Leu 
    1010                 1015                 


<210>  6701
<211>  61
<212>  PRT
<213>  Homo Sapiens

<400>  6701

Met Arg Tyr Arg Leu Ala Trp Leu Leu His Pro Ala Leu Pro Ser Thr 
1               5                   10                  15      


Phe Arg Ser Val Leu Gly Ala Arg Leu Pro Pro Pro Glu Arg Leu Cys 
            20                  25                  30          


Gly Asn Tyr Gln Val Val Phe Gln Ser Ser Gly Thr Ile Leu His Phe 
        35                  40                  45              


His Gln Gln Cys Val Lys Ile Pro Ile Ser Leu Tyr Pro 
    50                  55                  60      


<210>  6702
<211>  464
<212>  PRT
<213>  Homo Sapiens

<400>  6702

Met Ser Lys Leu Trp Phe Lys Gln Asp Asp Lys Phe Phe Leu Pro Lys 
1               5                   10                  15      


Ala Cys Leu Asn Phe Glu Phe Phe Ser Pro Phe Ala Tyr Val Asp Pro 
            20                  25                  30          


Leu His Cys Asn Met Ala Tyr Leu Tyr Leu Glu Leu Leu Lys Asp Ser 
        35                  40                  45              


Leu Asn Glu Tyr Ala Tyr Ala Ala Glu Leu Ala Gly Leu Ser Tyr Asp 
    50                  55                  60                  


Leu Gln Asn Thr Ile Tyr Gly Met Tyr Leu Ser Val Lys Gly Tyr Asn 
65                  70                  75                  80  


Asp Lys Gln Pro Ile Leu Leu Lys Lys Ile Ile Glu Lys Met Ala Thr 
                85                  90                  95      


Phe Glu Ile Asp Glu Lys Arg Phe Glu Ile Ile Lys Glu Ala Tyr Met 
            100                 105                 110         


Arg Ser Leu Asn Asn Phe Arg Ala Glu Gln Pro His Gln His Ala Met 
        115                 120                 125             


Tyr Tyr Leu Arg Leu Leu Met Thr Glu Val Ala Trp Thr Lys Asp Glu 
    130                 135                 140                 


Leu Lys Glu Ala Leu Asp Asp Val Thr Leu Pro Arg Leu Lys Ala Phe 
145                 150                 155                 160 


Ile Pro Gln Leu Leu Ser Arg Leu His Ile Glu Ala Leu Leu His Gly 
                165                 170                 175     


Asn Ile Thr Lys Gln Ala Ala Leu Gly Ile Met Gln Met Val Glu Asp 
            180                 185                 190         


Thr Leu Ile Glu His Ala His Thr Lys Pro Leu Leu Pro Ser Gln Leu 
        195                 200                 205             


Val Arg Tyr Arg Glu Val Gln Leu Pro Asp Arg Gly Trp Phe Val Tyr 
    210                 215                 220                 


Gln Gln Arg Asn Glu Val His Asn Asn Cys Gly Ile Glu Ile Tyr Tyr 
225                 230                 235                 240 


Gln Thr Asp Met Gln Ser Thr Ser Glu Asn Met Phe Leu Glu Leu Phe 
                245                 250                 255     


Cys Gln Ile Ile Ser Glu Pro Cys Phe Asn Thr Leu Arg Thr Lys Glu 
            260                 265                 270         


Gln Leu Gly Tyr Ile Val Phe Ser Gly Pro Arg Arg Ala Asn Gly Ile 
        275                 280                 285             


Gln Gly Leu Arg Phe Ile Ile Gln Ser Glu Lys Pro Pro His Tyr Leu 
    290                 295                 300                 


Glu Ser Arg Val Glu Ala Phe Leu Ile Thr Met Glu Lys Ser Ile Glu 
305                 310                 315                 320 


Asp Met Thr Glu Glu Ala Phe Gln Lys His Ile Gln Ala Leu Ala Ile 
                325                 330                 335     


Arg Arg Leu Asp Lys Pro Lys Lys Leu Ser Ala Glu Cys Ala Lys Tyr 
            340                 345                 350         


Trp Gly Glu Ile Ile Ser Gln Gln Tyr Asn Phe Asp Arg Asp Asn Thr 
        355                 360                 365             


Glu Val Ala Tyr Leu Lys Thr Leu Thr Lys Glu Asp Ile Ile Lys Phe 
    370                 375                 380                 


Tyr Lys Glu Met Leu Ala Val Asp Ala Pro Arg Arg His Lys Val Ser 
385                 390                 395                 400 


Val His Val Leu Ala Arg Glu Met Asp Ser Cys Pro Val Val Gly Glu 
                405                 410                 415     


Phe Pro Cys Gln Asn Asp Ile Asn Leu Ser Gln Ala Pro Ala Leu Pro 
            420                 425                 430         


Gln Pro Glu Val Ile Gln Asn Met Thr Glu Phe Lys Arg Gly Leu Pro 
        435                 440                 445             


Leu Phe Pro Leu Val Lys Pro His Ile Asn Phe Met Ala Ala Lys Leu 
    450                 455                 460                 


<210>  6703
<211>  106
<212>  PRT
<213>  Homo Sapiens

<400>  6703

Met Ala Ala Pro Gly Ala Leu Leu Val Met Gly Thr Leu Thr Leu Ser 
1               5                   10                  15      


Pro Arg Leu Glu Tyr Ser Gly Val Ile Ser Ala His Cys Asn Leu Cys 
            20                  25                  30          


Leu Leu Ser Ser Ser Asp Cys His Ala Ser Ala Ser Gly Val Thr Gly 
        35                  40                  45              


Val Thr Gly Val His His His Thr Gln Leu Ser Phe Val Phe Leu Val 
    50                  55                  60                  


Glu Thr Gly Phe Cys His Val Gly Arg Ala Ser Pro Glu Leu Leu Ala 
65                  70                  75                  80  


Ser Ser Asp Pro Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Ile Gly 
                85                  90                  95      


Val Ser Gln Gly Leu Asn Leu Thr Trp Ser 
            100                 105     


<210>  6704
<211>  187
<212>  PRT
<213>  Homo Sapiens

<400>  6704

Met Ala Ala Pro Gly Ala Leu Leu Val Met Gly Val Ser Gly Ser Gly 
1               5                   10                  15      


Lys Ser Thr Val Gly Ala Leu Leu Ala Ser Glu Leu Gly Trp Lys Phe 
            20                  25                  30          


Tyr Asp Ala Asp Asp Tyr His Pro Glu Glu Asn Arg Arg Lys Met Gly 
        35                  40                  45              


Lys Gly Ile Pro Leu Asn Asp Gln Asp Arg Ile Pro Trp Leu Cys Asn 
    50                  55                  60                  


Leu His Asp Ile Leu Leu Arg Asp Val Ala Ser Gly Gln Arg Val Val 
65                  70                  75                  80  


Leu Ala Cys Ser Ala Leu Lys Lys Thr Tyr Arg Asp Ile Leu Thr Gln 
                85                  90                  95      


Gly Lys Asp Gly Val Ala Leu Lys Cys Glu Glu Ser Gly Lys Glu Ala 
            100                 105                 110         


Lys Gln Ala Glu Met Gln Leu Leu Val Val His Leu Ser Gly Ser Phe 
        115                 120                 125             


Glu Val Ile Ser Gly Arg Leu Leu Lys Arg Glu Gly His Phe Met Pro 
    130                 135                 140                 


Pro Glu Leu Leu Gln Ser Gln Phe Glu Thr Leu Glu Pro Pro Ala Ala 
145                 150                 155                 160 


Pro Glu Asn Phe Ile Gln Ile Ser Val Asp Lys Asn Val Ser Glu Ile 
                165                 170                 175     


Ile Ala Thr Ile Met Glu Thr Leu Lys Met Lys 
            180                 185         


<210>  6705
<211>  90
<212>  PRT
<213>  Homo Sapiens

<400>  6705

Met Ala Ala Pro Gly Ala Leu Leu Val Met Gly Val Ser Gly Ser Gly 
1               5                   10                  15      


Lys Ser Thr Val Gly Ala Leu Leu Ala Ser Glu Leu Gly Trp Lys Phe 
            20                  25                  30          


Tyr Asp Ala Asp Asp Tyr His Pro Glu Glu Asn Arg Arg Lys Met Gly 
        35                  40                  45              


Lys Gly Ile Pro Leu Asn Asp Gln Arg Cys Ser Leu Gly Thr Ala Cys 
    50                  55                  60                  


Gly Ser Ser Leu Phe Ser Pro Glu Glu Asn Val Gln Arg His Ile Asn 
65                  70                  75                  80  


Thr Arg Lys Arg Trp Cys Ser Ser Glu Val 
                85                  90  


<210>  6706
<211>  59
<212>  PRT
<213>  Homo Sapiens

<400>  6706

Met Ala Ala Pro Gly Ala Leu Leu Val Met Gly Val Ser Gly Ser Gly 
1               5                   10                  15      


Asn Trp Asp Gly Asn Ser Met Met Leu Met Ile Ile Thr Arg Arg Lys 
            20                  25                  30          


Ile Glu Gly Arg Trp Glu Lys Ala Tyr Arg Ser Met Thr Arg Thr Gly 
        35                  40                  45              


Phe His Gly Ser Val Thr Cys Met Thr Phe Tyr 
    50                  55                  


<210>  6707
<211>  90
<212>  PRT
<213>  Homo Sapiens

<400>  6707

Met Gly Lys Gly Ile Pro Leu Asn Asp Gln Asp Arg Ile Pro Trp Leu 
1               5                   10                  15      


Cys Asn Leu His Asp Ile Leu Leu Arg Asp Val Ala Ser Gly Gln Arg 
            20                  25                  30          


Val Val Leu Ala Cys Ser Ala Leu Lys Lys Thr Tyr Arg Asp Ile Leu 
        35                  40                  45              


Thr Gln Gly Lys Asp Gly Val Ala Leu Lys Cys Glu Glu Ser Gly Lys 
    50                  55                  60                  


Glu Ala Lys Gln Ala Glu Met Gln Leu Leu Val Val His Leu Ser Gly 
65                  70                  75                  80  


Ser Phe Glu Val Ile Ser Gly Arg Leu Leu 
                85                  90  


<210>  6708
<211>  141
<212>  PRT
<213>  Homo Sapiens

<400>  6708

Met Gly Lys Gly Ile Pro Leu Asn Asp Gln Asp Arg Ile Pro Trp Leu 
1               5                   10                  15      


Cys Asn Leu His Asp Ile Leu Leu Arg Asp Val Ala Ser Gly Gln Arg 
            20                  25                  30          


Val Val Leu Ala Cys Ser Ala Leu Lys Lys Thr Tyr Arg Asp Ile Leu 
        35                  40                  45              


Thr Gln Gly Lys Asp Gly Val Ala Leu Lys Cys Glu Glu Ser Gly Lys 
    50                  55                  60                  


Glu Ala Lys Gln Ala Glu Met Gln Leu Leu Val Val His Leu Ser Gly 
65                  70                  75                  80  


Ser Phe Glu Val Ile Ser Gly Arg Leu Leu Lys Arg Glu Gly His Phe 
                85                  90                  95      


Met Pro Pro Glu Leu Leu Gln Ser Gln Phe Glu Thr Leu Glu Pro Pro 
            100                 105                 110         


Ala Ala Pro Glu Asn Phe Ile Gln Ile Ser Val Asp Lys Asn Val Ser 
        115                 120                 125             


Glu Ile Ile Ala Thr Ile Met Glu Thr Leu Lys Met Lys 
    130                 135                 140     


<210>  6709
<211>  86
<212>  PRT
<213>  Homo Sapiens

<400>  6709

Met Pro Pro Pro Arg Thr Gly Arg Gly Leu Leu Trp Leu Gly Leu Val 
1               5                   10                  15      


Leu Ser Ser Val Cys Val Ala Leu Gly Ser Glu Thr Gln Ala Asn Ser 
            20                  25                  30          


Thr Thr Asp Ala Leu Asn Val Leu Leu Ile Ile Val Asp Asp Leu Arg 
        35                  40                  45              


Pro Ser Leu Gly Cys Tyr Gly Asp Lys Leu Val Arg Ser Pro Asn Ile 
    50                  55                  60                  


Asp Gln Leu Ala Ser His Ser Leu Leu Phe Gln Asn Ala Phe Ala Gln 
65                  70                  75                  80  


Gln Ala Val Cys Ala Pro 
                85      


<210>  6710
<211>  550
<212>  PRT
<213>  Homo Sapiens

<400>  6710

Met Pro Pro Pro Arg Thr Gly Arg Gly Leu Leu Trp Leu Gly Leu Val 
1               5                   10                  15      


Leu Ser Ser Val Cys Val Ala Leu Gly Ser Glu Thr Gln Ala Asn Ser 
            20                  25                  30          


Thr Thr Asp Ala Leu Asn Val Leu Leu Ile Ile Val Asp Asp Leu Arg 
        35                  40                  45              


Pro Ser Leu Gly Cys Tyr Gly Asp Lys Leu Val Arg Ser Pro Asn Ile 
    50                  55                  60                  


Asp Gln Leu Ala Ser His Ser Leu Leu Phe Gln Asn Ala Phe Ala Gln 
65                  70                  75                  80  


Gln Ala Val Cys Ala Pro Ser Arg Val Ser Phe Leu Thr Gly Arg Arg 
                85                  90                  95      


Pro Asp Thr Thr Arg Leu Tyr Asp Phe Asn Ser Tyr Trp Arg Val His 
            100                 105                 110         


Ala Gly Asn Phe Ser Thr Ile Pro Gln Tyr Phe Lys Glu Asn Gly Tyr 
        115                 120                 125             


Val Thr Met Ser Val Gly Lys Val Phe His Pro Gly Ile Ser Ser Asn 
    130                 135                 140                 


His Thr Asp Asp Ser Pro Tyr Ser Trp Ser Phe Pro Pro Tyr His Pro 
145                 150                 155                 160 


Ser Ser Glu Lys Tyr Glu Asn Thr Lys Thr Cys Arg Gly Pro Asp Gly 
                165                 170                 175     


Glu Leu His Ala Asn Leu Leu Cys Pro Val Asp Val Leu Asp Val Pro 
            180                 185                 190         


Glu Gly Thr Leu Pro Asp Lys Gln Ser Thr Glu Gln Ala Ile Gln Leu 
        195                 200                 205             


Leu Glu Lys Met Lys Thr Ser Ala Ser Pro Phe Phe Leu Ala Val Gly 
    210                 215                 220                 


Tyr His Lys Pro His Ile Pro Phe Arg Tyr Pro Lys Glu Phe Gln Lys 
225                 230                 235                 240 


Leu Tyr Pro Leu Glu Asn Ile Thr Leu Ala Pro Asp Pro Glu Val Pro 
                245                 250                 255     


Asp Gly Leu Pro Pro Val Ala Tyr Asn Pro Trp Met Asp Ile Arg Gln 
            260                 265                 270         


Arg Glu Asp Val Gln Ala Leu Asn Ile Ser Val Pro Tyr Gly Pro Ile 
        275                 280                 285             


Pro Val Asp Phe Gln Arg Lys Ile Arg Gln Ser Tyr Phe Ala Ser Val 
    290                 295                 300                 


Ser Tyr Leu Asp Thr Gln Val Gly Arg Leu Leu Ser Ala Leu Asp Asp 
305                 310                 315                 320 


Leu Gln Leu Ala Asn Ser Thr Ile Ile Ala Phe Thr Ser Asp His Gly 
                325                 330                 335     


Trp Ala Leu Gly Glu His Gly Glu Trp Ala Lys Tyr Ser Asn Phe Asp 
            340                 345                 350         


Val Ala Thr His Val Pro Leu Ile Phe Tyr Val Pro Gly Arg Thr Ala 
        355                 360                 365             


Ser Leu Pro Glu Ala Gly Glu Lys Leu Phe Pro Tyr Leu Asp Pro Phe 
    370                 375                 380                 


Asp Ser Ala Ser Gln Leu Met Glu Pro Gly Arg Gln Ser Met Asp Leu 
385                 390                 395                 400 


Val Glu Leu Val Ser Leu Phe Pro Thr Leu Ala Gly Leu Ala Gly Leu 
                405                 410                 415     


Gln Val Pro Pro Arg Cys Pro Val Pro Ser Phe His Val Glu Leu Cys 
            420                 425                 430         


Arg Glu Gly Lys Asn Leu Leu Lys His Phe Arg Phe Arg Asp Leu Glu 
        435                 440                 445             


Glu Asp Pro Tyr Leu Pro Gly Asn Pro Arg Glu Leu Ile Ala Tyr Ser 
    450                 455                 460                 


Gln Tyr Pro Arg Pro Ser Asp Ile Pro Gln Trp Asn Ser Asp Lys Pro 
465                 470                 475                 480 


Ser Leu Lys Asp Ile Lys Ile Met Gly Tyr Ser Ile Arg Thr Ile Asp 
                485                 490                 495     


Tyr Arg Tyr Thr Val Trp Val Gly Phe Asn Pro Asp Glu Phe Leu Ala 
            500                 505                 510         


Asn Phe Ser Asp Ile His Ala Gly Glu Leu Tyr Phe Val Asp Ser Asp 
        515                 520                 525             


Pro Leu Gln Asp His Asn Met Tyr Asn Asp Ser Gln Gly Gly Asp Leu 
    530                 535                 540                 


Phe Gln Leu Leu Met Pro 
545                 550 


<210>  6711
<211>  343
<212>  PRT
<213>  Homo Sapiens

<400>  6711

Met Pro Pro Pro Arg Thr Gly Arg Gly Leu Leu Trp Leu Gly Leu Val 
1               5                   10                  15      


Leu Ser Ser Val Cys Val Ala Leu Gly Ser Glu Thr Gln Ala Asn Ser 
            20                  25                  30          


Thr Thr Asp Ala Leu Asn Val Leu Leu Ile Ile Val Asp Asp Leu Arg 
        35                  40                  45              


Pro Ser Leu Gly Cys Tyr Gly Asp Lys Leu Val Arg Ser Pro Asn Ile 
    50                  55                  60                  


Asp Gln Leu Ala Ser His Ser Leu Leu Phe Gln Asn Ala Phe Ala Gln 
65                  70                  75                  80  


Gln Ala Val Cys Ala Pro Ser Arg Val Ser Phe Leu Thr Gly Arg Arg 
                85                  90                  95      


Pro Asp Thr Thr Arg Leu Tyr Asp Phe Asn Ser Tyr Trp Arg Val His 
            100                 105                 110         


Ala Gly Asn Phe Ser Thr Ile Pro Gln Tyr Phe Lys Glu Asn Gly Tyr 
        115                 120                 125             


Val Thr Met Ser Val Gly Lys Val Phe His Pro Gly Ile Ser Ser Asn 
    130                 135                 140                 


His Thr Asp Asp Ser Pro Tyr Ser Trp Ser Phe Pro Pro Tyr His Pro 
145                 150                 155                 160 


Ser Ser Glu Lys Tyr Glu Asn Thr Lys Thr Cys Arg Gly Pro Asp Gly 
                165                 170                 175     


Glu Leu His Ala Asn Leu Leu Cys Pro Val Asp Val Leu Asp Val Pro 
            180                 185                 190         


Glu Gly Thr Leu Pro Asp Lys Gln Ser Thr Glu Gln Ala Ile Gln Leu 
        195                 200                 205             


Leu Glu Lys Met Lys Thr Ser Ala Ser Pro Phe Phe Leu Ala Val Gly 
    210                 215                 220                 


Tyr His Lys Pro His Ile Pro Phe Arg Tyr Pro Lys Glu Phe Gln Lys 
225                 230                 235                 240 


Leu Tyr Pro Leu Glu Asn Ile Thr Leu Ala Pro Asp Pro Glu Val Pro 
                245                 250                 255     


Asp Gly Leu Pro Pro Val Ala Tyr Asn Pro Trp Met Asp Ile Arg Gln 
            260                 265                 270         


Arg Glu Asp Val Gln Ala Leu Asn Ile Ser Val Pro Tyr Gly Pro Ile 
        275                 280                 285             


Pro Val Asp Phe Gln Arg Lys Ile Arg Gln Ser Tyr Phe Ala Ser Val 
    290                 295                 300                 


Ser Tyr Leu Asp Thr Gln Val Gly Arg Leu Leu Ser Ala Leu Asp Asp 
305                 310                 315                 320 


Leu Gln Leu Ala Asn Ser Thr Ile Ile Ala Phe Thr Ser Asp His Gly 
                325                 330                 335     


Phe Leu Met Arg Thr Asn Thr 
            340             


<210>  6712
<211>  312
<212>  PRT
<213>  Homo Sapiens

<400>  6712

Met Pro Pro Pro Arg Thr Gly Arg Gly Leu Leu Trp Leu Gly Leu Val 
1               5                   10                  15      


Leu Ser Ser Val Cys Val Ala Leu Gly Ser Glu Thr Gln Ala Asn Ser 
            20                  25                  30          


Thr Thr Asp Ala Leu Asn Val Leu Leu Ile Ile Val Asp Asp Leu Arg 
        35                  40                  45              


Pro Ser Leu Gly Cys Tyr Gly Asp Lys Leu Val Arg Ser Pro Asn Ile 
    50                  55                  60                  


Asp Gln Leu Ala Ser His Ser Leu Leu Phe Gln Asn Ala Phe Ala Gln 
65                  70                  75                  80  


Gln Ala Val Cys Ala Pro Ser Arg Val Ser Phe Leu Thr Gly Arg Arg 
                85                  90                  95      


Pro Asp Thr Thr Arg Leu Tyr Asp Phe Asn Ser Tyr Trp Arg Val His 
            100                 105                 110         


Ala Gly Asn Phe Ser Thr Ile Pro Gln Tyr Phe Lys Glu Asn Gly Tyr 
        115                 120                 125             


Val Thr Met Ser Val Gly Lys Val Phe His Pro Gly Ile Ser Ser Asn 
    130                 135                 140                 


His Thr Asp Asp Ser Pro Tyr Ser Trp Ser Phe Pro Pro Tyr His Pro 
145                 150                 155                 160 


Ser Ser Glu Lys Tyr Glu Asn Thr Lys Thr Cys Arg Gly Pro Asp Gly 
                165                 170                 175     


Glu Leu His Ala Asn Leu Leu Cys Pro Val Asp Val Leu Asp Val Pro 
            180                 185                 190         


Glu Gly Thr Leu Pro Asp Lys Gln Ser Thr Glu Gln Ala Ile Gln Leu 
        195                 200                 205             


Leu Glu Lys Met Lys Thr Ser Ala Ser Pro Phe Phe Leu Ala Val Gly 
    210                 215                 220                 


Tyr His Lys Pro His Ile Pro Phe Arg Tyr Pro Lys Glu Phe Gln Lys 
225                 230                 235                 240 


Leu Tyr Pro Leu Glu Asn Ile Thr Leu Ala Pro Asp Pro Glu Val Pro 
                245                 250                 255     


Asp Gly Leu Pro Pro Val Ala Tyr Asn Pro Trp Met Asp Ile Arg Gln 
            260                 265                 270         


Arg Glu Asp Val Gln Ala Leu Asn Ile Ser Val Pro Tyr Gly Pro Ile 
        275                 280                 285             


Pro Val Asp Phe Gln Glu Asp Gln Ser Ser Thr Gly Phe Arg Leu Lys 
    290                 295                 300                 


Thr Ser Ser Thr Arg Lys Tyr Lys 
305                 310         


<210>  6713
<211>  179
<212>  PRT
<213>  Homo Sapiens

<400>  6713

Met Pro Pro Pro Arg Thr Gly Arg Gly Leu Leu Trp Leu Gly Leu Val 
1               5                   10                  15      


Leu Ser Ser Val Cys Val Ala Leu Gly Ser Glu Thr Gln Ala Asn Ser 
            20                  25                  30          


Thr Thr Asp Ala Leu Asn Val Leu Leu Ile Ile Val Asp Asp Leu Arg 
        35                  40                  45              


Pro Ser Leu Gly Cys Tyr Gly Asp Lys Leu Val Arg Ser Pro Asn Ile 
    50                  55                  60                  


Asp Gln Leu Ala Ser His Ser Leu Leu Phe Gln Asn Ala Phe Ala Gln 
65                  70                  75                  80  


Gln Ala Val Cys Ala Pro Ser Arg Val Ser Phe Leu Thr Gly Arg Arg 
                85                  90                  95      


Pro Asp Thr Thr Arg Leu Tyr Asp Phe Asn Ser Tyr Trp Arg Val His 
            100                 105                 110         


Ala Gly Asn Phe Ser Thr Ile Pro Gln Tyr Phe Lys Glu Asn Gly Tyr 
        115                 120                 125             


Val Thr Met Ser Val Gly Lys Val Phe His Pro Gly Thr Ala Pro Cys 
    130                 135                 140                 


Pro Glu Ser Gly Phe Ser Trp Phe Val Val Ser Glu Ser Ser Ile Pro 
145                 150                 155                 160 


Ile Leu Gly Met Gly Leu Ser Leu Gln Ser Pro Leu Leu Ala Gly Arg 
                165                 170                 175     


Val Pro Arg 
            


<210>  6714
<211>  106
<212>  PRT
<213>  Homo Sapiens

<400>  6714

Arg Ser Pro Asn Ile Asp Gln Leu Ala Ser His Ser Leu Leu Phe Gln 
1               5                   10                  15      


Asn Ala Phe Ala Gln Gln Ala Val Cys Ala Pro Ser Arg Val Ser Phe 
            20                  25                  30          


Leu Thr Gly Arg Arg Pro Asp Thr Thr Arg Leu Tyr Asp Phe Asn Ser 
        35                  40                  45              


Tyr Trp Arg Val His Ala Gly Asn Phe Ser Thr Ile Pro Gln Tyr Phe 
    50                  55                  60                  


Lys Glu Asn Gly Tyr Val Thr Met Ser Val Gly Lys Val Phe His Pro 
65                  70                  75                  80  


Ala Leu Val Gly Thr His Phe Ser Ala Glu Ser Leu Phe Ser Arg Pro 
                85                  90                  95      


Phe Ser Val Ser Ile Gly Pro Ala Ser Arg 
            100                 105     


<210>  6715
<211>  232
<212>  PRT
<213>  Homo Sapiens

<400>  6715

Leu Ala His Pro Gly Pro Gly Ile Gly Ala Gly Pro Ser Pro Gly Ser 
1               5                   10                  15      


Ala Gly Pro Ser Pro Leu Pro Gly Met Asp Gly Arg Trp Ala Leu Leu 
            20                  25                  30          


Asp Pro Glu Ser Ile Val Arg Gly Ser Thr Gly Arg Gly Leu Ser Tyr 
        35                  40                  45              


Asn Phe Thr His Leu Asp Gly Tyr Leu Asp Leu Leu Arg Glu Asn Gln 
    50                  55                  60                  


Leu Leu Pro Gly Phe Glu Leu Met Gly Ser Ala Ser Gly His Phe Thr 
65                  70                  75                  80  


Asp Phe Glu Asp Lys Gln Gln Val Phe Glu Trp Lys Asp Leu Val Ser 
                85                  90                  95      


Ser Leu Ala Arg Arg Tyr Ile Gly Arg Tyr Gly Leu Ala His Val Ser 
            100                 105                 110         


Lys Trp Asn Phe Glu Thr Trp Asn Glu Pro Asp His His Asp Phe Asp 
        115                 120                 125             


Asn Val Ser Met Thr Met Gln Gly Phe Leu Asn Tyr Tyr Asp Ala Cys 
    130                 135                 140                 


Ser Glu Gly Leu Arg Ala Ala Ser Pro Ala Leu Arg Leu Gly Gly Pro 
145                 150                 155                 160 


Gly Asp Ser Phe His Thr Pro Pro Arg Ser Pro Leu Ser Trp Gly Leu 
                165                 170                 175     


Leu Arg His Cys His Asp Gly Thr Asn Phe Phe Thr Gly Glu Ala Gly 
            180                 185                 190         


Val Arg Leu Asp Tyr Ile Ser Leu His Arg Lys Gly Ala Arg Ser Ser 
        195                 200                 205             


Ile Ser Ile Leu Glu Gln Glu Lys Val Val Ala Gln Gln Ile Arg Gln 
    210                 215                 220                 


Leu Phe Pro Lys Phe Ala Asp Thr 
225                 230         


<210>  6716
<211>  176
<212>  PRT
<213>  Homo Sapiens

<400>  6716

Met Cys Leu Pro Ser Glu Cys His Ser His Trp Thr Gln Val Gln Ala 
1               5                   10                  15      


Ser Leu Ser Pro Ala Ala Pro Cys Pro Pro Pro Trp Leu Pro Arg Gly 
            20                  25                  30          


Ser Thr Gly Arg Gly Leu Ser Tyr Asn Phe Thr His Leu Asp Gly Tyr 
        35                  40                  45              


Leu Asp Leu Leu Arg Glu Asn Gln Leu Leu Pro Gly Phe Glu Leu Met 
    50                  55                  60                  


Gly Ser Ala Ser Gly His Phe Thr Asp Phe Glu Asp Lys Gln Gln Val 
65                  70                  75                  80  


Phe Glu Trp Lys Asp Leu Val Ser Ser Leu Ala Arg Arg Tyr Ile Gly 
                85                  90                  95      


Arg Tyr Gly Leu Ala His Val Ser Lys Trp Asn Phe Glu Thr Trp Asn 
            100                 105                 110         


Glu Pro Asp His His Asp Phe Asp Asn Val Ser Met Thr Met Gln Gly 
        115                 120                 125             


Phe Leu Asn Tyr Tyr Asp Ala Cys Ser Glu Gly Leu Arg Ala Ala Ser 
    130                 135                 140                 


Pro Ala Leu Arg Leu Gly Gly Pro Gly Asp Ser Phe His Thr Pro Pro 
145                 150                 155                 160 


Arg Ser Pro Leu Ser Trp Gly Leu Leu Arg His Cys His Asp Gly Thr 
                165                 170                 175     


<210>  6717
<211>  521
<212>  PRT
<213>  Homo Sapiens

<400>  6717

Met Gly Ser Ala Ser Gly His Phe Thr Asp Phe Glu Asp Lys Gln Gln 
1               5                   10                  15      


Val Phe Glu Trp Lys Asp Leu Val Ser Ser Leu Ala Arg Arg Tyr Ile 
            20                  25                  30          


Gly Arg Tyr Gly Leu Ala His Val Ser Lys Trp Asn Phe Glu Thr Trp 
        35                  40                  45              


Asn Glu Pro Asp His His Asp Phe Asp Asn Val Ser Met Thr Met Gln 
    50                  55                  60                  


Gly Phe Leu Asn Tyr Tyr Asp Ala Cys Ser Glu Gly Leu Arg Ala Ala 
65                  70                  75                  80  


Ser Pro Ala Leu Arg Leu Gly Gly Pro Gly Asp Ser Phe His Thr Pro 
                85                  90                  95      


Pro Arg Ser Pro Leu Ser Trp Gly Leu Leu Arg His Cys His Asp Gly 
            100                 105                 110         


Thr Asn Phe Phe Thr Gly Glu Ala Gly Val Arg Leu Asp Tyr Ile Ser 
        115                 120                 125             


Leu His Arg Lys Gly Ala Arg Ser Ser Ile Ser Ile Leu Glu Gln Glu 
    130                 135                 140                 


Lys Val Val Ala Gln Gln Ile Arg Gln Leu Phe Pro Lys Phe Ala Asp 
145                 150                 155                 160 


Thr Pro Ile Tyr Asn Asp Glu Ala Asp Pro Leu Val Gly Trp Ser Leu 
                165                 170                 175     


Pro Gln Pro Trp Arg Ala Asp Val Thr Tyr Ala Ala Met Val Val Lys 
            180                 185                 190         


Val Ile Ala Gln His Gln Asn Leu Leu Leu Ala Asn Thr Thr Ser Ala 
        195                 200                 205             


Phe Pro Tyr Ala Leu Leu Ser Asn Asp Asn Ala Phe Leu Ser Tyr His 
    210                 215                 220                 


Pro His Pro Phe Ala Gln Arg Thr Leu Thr Ala Arg Phe Gln Val Asn 
225                 230                 235                 240 


Asn Thr Arg Pro Pro His Val Gln Leu Leu Arg Lys Pro Val Leu Thr 
                245                 250                 255     


Ala Met Gly Leu Leu Ala Leu Leu Asp Glu Glu Gln Leu Trp Ala Glu 
            260                 265                 270         


Val Ser Gln Ala Gly Thr Val Leu Asp Ser Asn His Thr Val Gly Val 
        275                 280                 285             


Leu Ala Ser Ala His Arg Pro Gln Gly Pro Ala Asp Ala Trp Arg Ala 
    290                 295                 300                 


Ala Val Leu Ile Tyr Ala Ser Asp Asp Thr Arg Ala His Pro Asn Arg 
305                 310                 315                 320 


Ser Val Ala Val Thr Leu Arg Leu Arg Gly Val Pro Pro Gly Pro Gly 
                325                 330                 335     


Leu Val Tyr Val Thr Arg Tyr Leu Asp Asn Gly Leu Cys Ser Pro Asp 
            340                 345                 350         


Gly Glu Trp Arg Arg Leu Gly Arg Pro Val Phe Pro Thr Ala Glu Gln 
        355                 360                 365             


Phe Arg Arg Met Arg Ala Ala Glu Asp Pro Val Ala Ala Ala Pro Arg 
    370                 375                 380                 


Pro Leu Pro Ala Gly Gly Arg Leu Thr Leu Arg Pro Ala Leu Arg Leu 
385                 390                 395                 400 


Pro Ser Leu Leu Leu Val His Val Cys Ala Arg Pro Glu Lys Pro Pro 
                405                 410                 415     


Gly Gln Val Thr Arg Leu Arg Ala Leu Pro Leu Thr Gln Gly Gln Leu 
            420                 425                 430         


Val Leu Val Trp Ser Asp Glu His Val Gly Ser Lys Cys Leu Trp Thr 
        435                 440                 445             


Tyr Glu Ile Gln Phe Ser Gln Asp Gly Lys Ala Tyr Thr Pro Val Ser 
    450                 455                 460                 


Arg Lys Pro Ser Thr Phe Asn Leu Phe Val Phe Ser Pro Asp Thr Gly 
465                 470                 475                 480 


Ala Val Ser Gly Ser Tyr Arg Val Arg Ala Leu Asp Tyr Trp Ala Arg 
                485                 490                 495     


Pro Gly Pro Phe Ser Asp Pro Val Pro Tyr Leu Glu Val Pro Val Pro 
            500                 505                 510         


Arg Gly Pro Pro Ser Pro Gly Asn Pro 
        515                 520     


<210>  6718
<211>  653
<212>  PRT
<213>  Homo Sapiens

<400>  6718

Met Arg Pro Leu Arg Pro Arg Ala Ala Leu Leu Ala Leu Leu Ala Ser 
1               5                   10                  15      


Leu Leu Ala Ala Pro Pro Val Ala Pro Ala Glu Ala Pro His Leu Val 
            20                  25                  30          


His Val Asp Ala Ala Arg Ala Leu Trp Pro Leu Arg Arg Phe Trp Arg 
        35                  40                  45              


Ser Thr Gly Phe Cys Pro Pro Leu Pro His Ser Gln Ala Asp Gln Tyr 
    50                  55                  60                  


Val Leu Ser Trp Asp Gln Gln Leu Asn Leu Ala Tyr Val Gly Ala Val 
65                  70                  75                  80  


Pro His Arg Gly Ile Lys Gln Val Arg Thr His Trp Leu Leu Glu Leu 
                85                  90                  95      


Val Thr Thr Arg Gly Ser Thr Gly Arg Gly Leu Ser Tyr Asn Phe Thr 
            100                 105                 110         


His Leu Asp Gly Tyr Leu Asp Leu Leu Arg Glu Asn Gln Leu Leu Pro 
        115                 120                 125             


Gly Phe Glu Leu Met Gly Ser Ala Ser Gly His Phe Thr Asp Phe Glu 
    130                 135                 140                 


Asp Lys Gln Gln Val Phe Glu Trp Lys Asp Leu Val Ser Ser Leu Ala 
145                 150                 155                 160 


Arg Arg Tyr Ile Gly Arg Tyr Gly Leu Ala His Val Ser Lys Trp Asn 
                165                 170                 175     


Phe Glu Thr Trp Asn Glu Pro Asp His His Asp Phe Asp Asn Val Ser 
            180                 185                 190         


Met Thr Met Gln Gly Phe Leu Asn Tyr Tyr Asp Ala Cys Ser Glu Gly 
        195                 200                 205             


Leu Arg Ala Ala Ser Pro Ala Leu Arg Leu Gly Gly Pro Gly Asp Ser 
    210                 215                 220                 


Phe His Thr Pro Pro Arg Ser Pro Leu Ser Trp Gly Leu Leu Arg His 
225                 230                 235                 240 


Cys His Asp Gly Thr Asn Phe Phe Thr Gly Glu Ala Gly Val Arg Leu 
                245                 250                 255     


Asp Tyr Ile Ser Leu His Arg Lys Gly Ala Arg Ser Ser Ile Ser Ile 
            260                 265                 270         


Leu Glu Gln Glu Lys Val Val Ala Gln Gln Ile Arg Gln Leu Phe Pro 
        275                 280                 285             


Lys Phe Ala Asp Thr Pro Ile Tyr Asn Asp Glu Ala Asp Pro Leu Val 
    290                 295                 300                 


Gly Trp Ser Leu Pro Gln Pro Trp Arg Ala Asp Val Thr Tyr Ala Ala 
305                 310                 315                 320 


Met Val Val Lys Val Ile Ala Gln His Gln Asn Leu Leu Leu Ala Asn 
                325                 330                 335     


Thr Thr Ser Ala Phe Pro Tyr Ala Leu Leu Ser Asn Asp Asn Ala Phe 
            340                 345                 350         


Leu Ser Tyr His Pro His Pro Phe Ala Gln Arg Thr Leu Thr Ala Arg 
        355                 360                 365             


Phe Gln Val Asn Asn Thr Arg Pro Pro His Val Gln Leu Leu Arg Lys 
    370                 375                 380                 


Pro Val Leu Thr Ala Met Gly Leu Leu Ala Leu Leu Asp Glu Glu Gln 
385                 390                 395                 400 


Leu Trp Ala Glu Val Ser Gln Ala Gly Thr Val Leu Asp Ser Asn His 
                405                 410                 415     


Thr Val Gly Val Leu Ala Ser Ala His Arg Pro Gln Gly Pro Ala Asp 
            420                 425                 430         


Ala Trp Arg Ala Ala Val Leu Ile Tyr Ala Ser Asp Asp Thr Arg Ala 
        435                 440                 445             


His Pro Asn Arg Ser Val Ala Val Thr Leu Arg Leu Arg Gly Val Pro 
    450                 455                 460                 


Pro Gly Pro Gly Leu Val Tyr Val Thr Arg Tyr Leu Asp Asn Gly Leu 
465                 470                 475                 480 


Cys Ser Pro Asp Gly Glu Trp Arg Arg Leu Gly Arg Pro Val Phe Pro 
                485                 490                 495     


Thr Ala Glu Gln Phe Arg Arg Met Arg Ala Ala Glu Asp Pro Val Ala 
            500                 505                 510         


Ala Ala Pro Arg Pro Leu Pro Ala Gly Gly Arg Leu Thr Leu Arg Pro 
        515                 520                 525             


Ala Leu Arg Leu Pro Ser Leu Leu Leu Val His Val Cys Ala Arg Pro 
    530                 535                 540                 


Glu Lys Pro Pro Gly Gln Val Thr Arg Leu Arg Ala Leu Pro Leu Thr 
545                 550                 555                 560 


Gln Gly Gln Leu Val Leu Val Trp Ser Asp Glu His Val Gly Ser Lys 
                565                 570                 575     


Cys Leu Trp Thr Tyr Glu Ile Gln Phe Ser Gln Asp Gly Lys Ala Tyr 
            580                 585                 590         


Thr Pro Val Ser Arg Lys Pro Ser Thr Phe Asn Leu Phe Val Phe Ser 
        595                 600                 605             


Pro Asp Thr Gly Ala Val Ser Gly Ser Tyr Arg Val Arg Ala Leu Asp 
    610                 615                 620                 


Tyr Trp Ala Arg Pro Gly Pro Phe Ser Asp Pro Val Pro Tyr Leu Glu 
625                 630                 635                 640 


Val Pro Val Pro Arg Gly Pro Pro Ser Pro Gly Asn Pro 
                645                 650             


<210>  6719
<211>  224
<212>  PRT
<213>  Homo Sapiens

<400>  6719

Met Arg Pro Leu Arg Pro Arg Ala Ala Leu Leu Ala Leu Leu Ala Ser 
1               5                   10                  15      


Leu Leu Ala Ala Pro Pro Val Ala Pro Ala Glu Ala Pro His Leu Val 
            20                  25                  30          


His Val Asp Ala Ala Arg Ala Leu Trp Pro Leu Arg Arg Phe Trp Arg 
        35                  40                  45              


Ser Thr Gly Phe Trp Gly Ser Thr Gly Arg Gly Leu Ser Tyr Asn Phe 
    50                  55                  60                  


Thr His Leu Asp Gly Tyr Leu Asp Leu Leu Arg Glu Asn Gln Leu Leu 
65                  70                  75                  80  


Pro Gly Phe Glu Leu Met Gly Ser Ala Ser Gly His Phe Thr Asp Phe 
                85                  90                  95      


Glu Asp Lys Gln Gln Val Phe Glu Trp Lys Asp Leu Val Ser Ser Leu 
            100                 105                 110         


Ala Arg Arg Tyr Ile Gly Arg Tyr Gly Leu Ala His Val Ser Lys Trp 
        115                 120                 125             


Asn Phe Glu Thr Trp Asn Glu Pro Asp His His Asp Phe Asp Asn Val 
    130                 135                 140                 


Ser Met Thr Met Gln Gly Phe Leu Asn Tyr Tyr Asp Ala Cys Ser Glu 
145                 150                 155                 160 


Gly Leu Arg Ala Ala Ser Pro Ala Leu Arg Leu Gly Gly Pro Gly Asp 
                165                 170                 175     


Ser Phe His Thr Pro Pro Arg Ser Pro Leu Ser Trp Gly Leu Leu Arg 
            180                 185                 190         


His Cys His Asp Gly Thr Asn Phe Phe Thr Gly Glu Ala Gly Val Arg 
        195                 200                 205             


Leu Asp Tyr Ile Ser Leu His Arg Lys Gly Ala Arg Ser Ser Ile Ser 
    210                 215                 220                 


<210>  6720
<211>  196
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6720

Xaa Val Pro Cys Ala Pro Ala Pro Arg Cys Trp Arg Ser Trp Pro Arg 
1               5                   10                  15      


Ser Trp Pro Arg Pro Arg Trp Pro Arg Pro Arg Pro Arg Thr Trp Cys 
            20                  25                  30          


Met Trp Thr Arg Pro Ala Arg Cys Gly Pro Cys Gly Ala Ser Gly Gly 
        35                  40                  45              


Ala Gln Ala Ser Ala Pro Arg Cys His Thr Ala Arg Leu Thr Ser Thr 
    50                  55                  60                  


Ser Ser Ala Gly Thr Ser Ser Ser Thr Ser Pro Met Trp Ala Pro Ser 
65                  70                  75                  80  


Leu Thr Ala Ala Ser Ser Arg Gly Ser Thr Gly Arg Gly Leu Ser Tyr 
                85                  90                  95      


Asn Phe Thr His Leu Asp Gly Tyr Leu Asp Leu Leu Arg Glu Asn Gln 
            100                 105                 110         


Leu Leu Pro Gly Phe Glu Leu Met Gly Ser Ala Ser Gly His Phe Thr 
        115                 120                 125             


Asp Phe Glu Asp Lys Gln Gln Val Phe Glu Trp Lys Asp Leu Val Ser 
    130                 135                 140                 


Ser Leu Ala Arg Arg Tyr Ile Gly Arg Tyr Gly Leu Ala His Val Ser 
145                 150                 155                 160 


Lys Trp Asn Phe Glu Thr Trp Asn Glu Pro Asp His His Asp Phe Asp 
                165                 170                 175     


Asn Val Ser Met Thr Met Gln Gly Phe Leu Asn Tyr Tyr Asp Ala Cys 
            180                 185                 190         


Ser Glu Gly Leu 
        195     


<210>  6721
<211>  105
<212>  PRT
<213>  Homo Sapiens

<400>  6721

Met Gly Phe Thr Gly Ala Gly Ile Ala Ala Ser Ser Ile Ala Ala Lys 
1               5                   10                  15      


Met Met Ser Ala Ala Ala Ile Ala Asn Gly Gly Gly Val Ser Ala Gly 
            20                  25                  30          


Ser Leu Val Ala Thr Leu Gln Ser Val Gly Ala Ala Gly Leu Ser Thr 
        35                  40                  45              


Ser Ser Asn Ile Leu Leu Ala Ser Val Gly Ser Val Leu Gly Ala Cys 
    50                  55                  60                  


Leu Gly Asn Ser Pro Ser Ser Ser Leu Pro Ala Glu Pro Glu Ala Lys 
65                  70                  75                  80  


Glu Asp Glu Ala Arg Glu Asn Val Pro Gln Gly Glu Pro Pro Lys Pro 
                85                  90                  95      


Pro Leu Lys Ser Glu Lys His Glu Glu 
            100                 105 


<210>  6722
<211>  130
<212>  PRT
<213>  Homo Sapiens

<400>  6722

Met Met Lys Arg Ala Ala Ala Ala Ala Val Gly Gly Ala Leu Ala Val 
1               5                   10                  15      


Gly Ala Val Pro Val Val Leu Ser Ala Met Gly Phe Thr Gly Ala Gly 
            20                  25                  30          


Ile Ala Ala Ser Ser Ile Ala Ala Lys Met Met Ser Ala Ala Ala Ile 
        35                  40                  45              


Ala Asn Gly Gly Gly Val Ser Ala Gly Ser Leu Val Ala Thr Leu Gln 
    50                  55                  60                  


Ser Val Gly Ala Ala Gly Leu Ser Thr Ser Ser Asn Ile Leu Leu Ala 
65                  70                  75                  80  


Ser Val Gly Ser Val Leu Gly Ala Cys Leu Gly Asn Ser Pro Ser Ser 
                85                  90                  95      


Ser Leu Pro Ala Glu Pro Glu Ala Lys Glu Asp Glu Ala Arg Glu Asn 
            100                 105                 110         


Val Pro Gln Gly Glu Pro Pro Lys Pro Pro Leu Lys Ser Glu Lys His 
        115                 120                 125             


Glu Glu 
    130 


<210>  6723
<211>  105
<212>  PRT
<213>  Homo Sapiens

<400>  6723

Met Thr Leu Ser Pro Leu Leu Leu Phe Leu Pro Pro Leu Leu Leu Leu 
1               5                   10                  15      


Leu Asp Val Pro Thr Ala Ala Val Gln Ala Ser Pro Leu Gln Ala Leu 
            20                  25                  30          


Asp Phe Phe Gly Asn Gly Pro Pro Val Asn Tyr Lys Thr Gly Asn Leu 
        35                  40                  45              


Tyr Leu Arg Gly Pro Leu Lys Lys Ser Asn Ala Pro Leu Val Asn Val 
    50                  55                  60                  


Thr Leu Tyr Tyr Glu Ala Leu Cys Gly Gly Cys Arg Ala Phe Leu Ile 
65                  70                  75                  80  


Arg Glu Leu Phe Pro Thr Trp Leu Leu Val Met Glu Ile Leu Asn Val 
                85                  90                  95      


Thr Leu Val Pro Tyr Gly Asn Ala Gln 
            100                 105 


<210>  6724
<211>  250
<212>  PRT
<213>  Homo Sapiens

<400>  6724

Met Thr Leu Ser Pro Leu Leu Leu Phe Leu Pro Pro Leu Leu Leu Leu 
1               5                   10                  15      


Leu Asp Val Pro Thr Ala Ala Val Gln Ala Ser Pro Leu Gln Ala Leu 
            20                  25                  30          


Asp Phe Phe Gly Asn Gly Pro Pro Val Asn Tyr Lys Thr Gly Asn Leu 
        35                  40                  45              


Tyr Leu Arg Gly Pro Leu Lys Lys Ser Asn Ala Pro Leu Val Asn Val 
    50                  55                  60                  


Thr Leu Tyr Tyr Glu Ala Leu Cys Gly Gly Cys Arg Ala Phe Leu Ile 
65                  70                  75                  80  


Arg Glu Leu Phe Pro Thr Trp Leu Leu Val Met Glu Ile Leu Asn Val 
                85                  90                  95      


Thr Leu Val Pro Tyr Gly Asn Ala Gln Glu Gln Asn Val Ser Gly Arg 
            100                 105                 110         


Trp Glu Phe Lys Cys Gln His Gly Glu Glu Glu Cys Lys Phe Asn Lys 
        115                 120                 125             


Val Glu Ala Cys Val Leu Asp Glu Leu Asp Met Glu Leu Ala Phe Leu 
    130                 135                 140                 


Thr Ile Val Cys Met Glu Glu Phe Glu Asp Met Glu Arg Ser Leu Pro 
145                 150                 155                 160 


Leu Cys Leu Gln Leu Tyr Ala Pro Gly Leu Ser Pro Asp Thr Ile Met 
                165                 170                 175     


Glu Cys Ala Met Gly Asp Arg Gly Met Gln Leu Met His Ala Asn Ala 
            180                 185                 190         


Gln Arg Thr Asp Ala Leu Gln Pro Pro His Glu Tyr Val Pro Trp Val 
        195                 200                 205             


Thr Val Asn Gly Lys Pro Leu Glu Asp Gln Thr Gln Leu Leu Thr Leu 
    210                 215                 220                 


Val Cys Gln Leu Tyr Gln Gly Lys Lys Pro Asp Val Cys Pro Ser Ser 
225                 230                 235                 240 


Thr Ser Ser Leu Arg Ser Val Cys Phe Lys 
                245                 250 


<210>  6725
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  6725

Met Ala Ser Pro Phe Ala Leu Leu Met Val Leu Val Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Leu Gly Cys Asp Leu Pro Glu Thr His Ser Leu 
            20                  25                  30          


Asp Asn Arg Arg Thr Leu Met Leu Leu Ala Gln Met Ser Arg Ile Ser 
        35                  40                  45              


Pro Ser Ser Cys Leu Met Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Pro Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Leu Ile Gln Gln Ile Phe Asn Leu Phe Thr Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Asp Glu Asp Leu Leu Asp Lys Phe Cys Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Met Gln Glu Glu Arg 
        115                 120                 125             


Val Gly Glu Thr Pro Leu Met Asn Ala Asp Ser Ile Leu Ala Val Lys 
    130                 135                 140                 


Lys Tyr Phe Arg Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Leu Ser Thr Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 


<210>  6726
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  6726

Met Ala Leu Ser Phe Ser Leu Leu Met Ala Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Gly Gln Met Gly Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Arg Ile Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Glu Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Glu Gln Ser Leu Leu Glu Lys Phe Ser Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Ile Glu Arg Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Gln Lys Arg Leu Arg Arg Lys Asp 
            180                 185                 


<210>  6727
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  6727

Met Ala Ser Pro Phe Ala Leu Leu Met Ala Leu Val Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Leu Gly Cys Asp Leu Pro Glu Thr His Ser Leu 
            20                  25                  30          


Asp Asn Arg Arg Thr Leu Met Leu Leu Ala Gln Met Ser Arg Ile Ser 
        35                  40                  45              


Pro Ser Ser Cys Leu Met Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Pro Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Leu Ile Gln Gln Ile Phe Asn Leu Phe Thr Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Asp Glu Asp Leu Leu Asp Lys Phe Cys Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Met Gln Glu Glu Arg 
        115                 120                 125             


Val Gly Glu Thr Pro Leu Met Asn Ala Asp Ser Ile Leu Ala Val Lys 
    130                 135                 140                 


Lys Tyr Phe Arg Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Leu Ser Thr Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 


<210>  6728
<211>  190
<212>  PRT
<213>  Homo Sapiens

<400>  6728

Met Met Ala Ser Pro Phe Ala Leu Leu Met Ala Leu Val Val Leu Ser 
1               5                   10                  15      


Cys Lys Ser Ser Cys Ser Leu Gly Cys Asp Leu Pro Glu Thr His Ser 
            20                  25                  30          


Leu Asp Asn Arg Arg Thr Leu Met Leu Leu Ala Gln Met Ser Arg Ile 
        35                  40                  45              


Ser Pro Ser Ser Cys Leu Met Asp Arg His Asp Phe Gly Phe Pro Gln 
    50                  55                  60                  


Glu Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Pro Ala Ile Ser Val 
65                  70                  75                  80  


Leu His Glu Leu Ile Gln Gln Ile Phe Asn Leu Phe Thr Thr Lys Asp 
                85                  90                  95      


Ser Ser Ala Ala Trp Asp Glu Asp Leu Leu Asp Lys Phe Cys Thr Glu 
            100                 105                 110         


Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Met Gln Glu Glu 
        115                 120                 125             


Arg Val Gly Glu Thr Pro Leu Met Asn Ala Asp Ser Ile Leu Ala Val 
    130                 135                 140                 


Lys Lys Tyr Phe Arg Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr 
145                 150                 155                 160 


Ser Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu 
                165                 170                 175     


Ser Leu Ser Thr Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 190 


<210>  6729
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  6729

Met Ala Leu Pro Phe Ala Leu Met Met Ala Leu Val Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Leu Gly Cys Asn Leu Ser Gln Thr His Ser Leu 
            20                  25                  30          


Asn Asn Arg Arg Thr Leu Met Leu Met Ala Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Glu Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Met Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asn Ser 
                85                  90                  95      


Ser Ala Ala Trp Asp Glu Thr Leu Leu Glu Lys Phe Tyr Ile Glu Leu 
            100                 105                 110         


Phe Gln Gln Met Asn Asp Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Lys 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Met Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Gln Lys Arg Leu Arg Arg Lys Asp 
            180                 185                 


<210>  6730
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  6730

Met Ala Leu Ser Phe Ser Leu Leu Met Ala Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


His Phe Ser Cys Leu Lys Asp Arg Tyr Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Val Phe Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Ala Phe 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Ile Glu Leu 
            100                 105                 110         


Phe Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Thr Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Ile Ala Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Met Gly Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Gln Lys Gly Leu Arg Arg Lys Asp 
            180                 185                 


<210>  6731
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  6731

Met Ala Leu Ser Phe Ser Leu Leu Met Ala Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Leu Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Thr Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Glu Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Glu Gln Ser Leu Leu Glu Lys Phe Ser Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asn Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Met Glu Glu Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Gln Lys Ile Leu Arg Arg Lys Asp 
            180                 185                 


<210>  6732
<211>  188
<212>  PRT
<213>  Homo Sapiens

<400>  6732

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Ser Arg Arg Thr Leu Met Leu Leu Ala Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Leu Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Gly Asn Gln Phe Gln Lys Ala Glu Thr Ile Pro Val Leu His 
65                  70                  75                  80  


Glu Met Ile Gln Gln Ile Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser 
                85                  90                  95      


Ala Ala Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu Tyr 
            100                 105                 110         


Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Gly Val Gly Val 
        115                 120                 125             


Thr Glu Thr Pro Leu Met Lys Glu Asp Ser Ile Leu Ala Val Arg Lys 
    130                 135                 140                 


Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Lys Glu Lys Lys Tyr Ser Pro 
145                 150                 155                 160 


Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser Leu 
                165                 170                 175     


Ser Thr Asn Leu Gln Glu Ser Leu Arg Ser Lys Glu 
            180                 185             


<210>  6733
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  6733

Met Ala Leu Ser Phe Ser Leu Leu Met Ala Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Thr Trp Glu Gln Ser Leu Leu Glu Lys Phe Ser Thr Glu Leu 
            100                 105                 110         


Asn Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Thr Pro Leu Met Asn Val Asp Ser Ile Leu Ala Val Lys 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Leu Ser Lys Ile Phe Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 


<210>  6734
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  6734

Met Ala Leu Ser Phe Ser Leu Leu Met Ala Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


His Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Glu Glu 
    50                  55                  60                  


Glu Phe Asp Gly His Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Glu Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Glu Gln Ser Leu Leu Glu Lys Phe Ser Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Gln Lys Arg Leu Arg Arg Lys Asp 
            180                 185                 


<210>  6735
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  6735

Met Ala Leu Pro Phe Val Leu Leu Met Ala Leu Val Val Leu Asn Cys 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Ser Asn Arg Arg Thr Leu Met Ile Met Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Thr Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Met Met Gln Glu Val Gly 
        115                 120                 125             


Val Glu Asp Thr Pro Leu Met Asn Val Asp Ser Ile Leu Thr Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Leu Ser Ala Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 


<210>  6736
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  6736

Met Ala Leu Pro Phe Ala Leu Leu Met Ala Leu Val Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Leu Asp Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly His Arg Arg Thr Met Met Leu Leu Ala Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Leu Phe Ser Cys Leu Lys Asp Arg His Asp Phe Arg Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Glu Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Val Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser 
                85                  90                  95      


Ser Val Ala Trp Asp Glu Arg Leu Leu Asp Lys Leu Tyr Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Met Gln Glu Val Trp 
        115                 120                 125             


Val Gly Gly Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Ser Ser Arg Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 


<210>  6737
<211>  190
<212>  PRT
<213>  Homo Sapiens

<400>  6737

Thr Met Ala Leu Pro Phe Ala Leu Leu Met Ala Leu Val Val Leu Ser 
1               5                   10                  15      


Cys Lys Ser Ser Cys Ser Leu Asp Cys Asp Leu Pro Gln Thr His Ser 
            20                  25                  30          


Leu Gly His Arg Arg Thr Met Met Leu Leu Ala Gln Met Arg Arg Ile 
        35                  40                  45              


Ser Leu Phe Ser Cys Leu Lys Asp Arg His Asp Phe Arg Phe Pro Gln 
    50                  55                  60                  


Glu Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Glu Ala Ile Ser Val 
65                  70                  75                  80  


Leu His Glu Val Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp 
                85                  90                  95      


Ser Ser Val Ala Trp Asp Glu Arg Leu Leu Asp Lys Leu Tyr Thr Glu 
            100                 105                 110         


Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Met Gln Glu Val 
        115                 120                 125             


Trp Val Gly Gly Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val 
    130                 135                 140                 


Arg Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr 
145                 150                 155                 160 


Ser Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe 
                165                 170                 175     


Ser Ser Ser Arg Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 190 


<210>  6738
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  6738

Met Ala Arg Ser Phe Ser Leu Leu Met Val Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Arg Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Glu Phe Arg Phe Pro Glu Glu 
    50                  55                  60                  


Glu Phe Asp Gly His Gln Phe Gln Lys Thr Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Glu Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Glu Gln Ser Leu Leu Glu Lys Phe Ser Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Thr Pro Leu Met Asn Glu Asp Phe Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Met Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Lys Lys Gly Leu Arg Arg Lys Asp 
            180                 185                 


<210>  6739
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  6739

Met Ala Leu Thr Phe Tyr Leu Leu Val Ala Leu Val Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Phe Ser Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Glu Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Asp Lys Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Ala Leu Asp Glu Thr Leu Leu Asp Glu Phe Tyr Ile Glu Leu 
            100                 105                 110         


Asp Gln Gln Leu Asn Asp Leu Glu Ser Cys Val Met Gln Glu Val Gly 
        115                 120                 125             


Val Ile Glu Ser Pro Leu Met Tyr Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Ser Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Leu Ser Ile Asn Leu Gln Lys Arg Leu Lys Ser Lys Glu 
            180                 185                 


<210>  6740
<211>  557
<212>  PRT
<213>  Homo Sapiens

<400>  6740

Met Met Val Val Leu Leu Gly Ala Thr Thr Leu Val Leu Val Ala Val 
1               5                   10                  15      


Ala Pro Trp Val Leu Ser Ala Ala Ala Gly Gly Lys Asn Leu Lys Ser 
            20                  25                  30          


Pro Gln Lys Val Glu Val Asp Ile Ile Asp Asp Asn Phe Ile Leu Arg 
        35                  40                  45              


Trp Asn Arg Ser Asp Glu Ser Val Gly Asn Val Thr Phe Ser Phe Asp 
    50                  55                  60                  


Tyr Gln Lys Thr Gly Met Asp Asn Trp Ile Lys Leu Ser Gly Cys Gln 
65                  70                  75                  80  


Asn Ile Thr Ser Thr Lys Cys Asn Phe Ser Ser Leu Lys Leu Asn Val 
                85                  90                  95      


Tyr Glu Glu Ile Lys Leu Arg Ile Arg Ala Glu Lys Glu Asn Thr Ser 
            100                 105                 110         


Ser Trp Tyr Glu Val Asp Ser Phe Thr Pro Phe Arg Lys Ala Gln Ile 
        115                 120                 125             


Gly Pro Pro Glu Val His Leu Glu Ala Glu Asp Lys Ala Ile Val Ile 
    130                 135                 140                 


His Ile Ser Pro Gly Thr Lys Asp Ser Val Met Trp Ala Leu Asp Gly 
145                 150                 155                 160 


Leu Ser Phe Thr Tyr Ser Leu Val Ile Trp Lys Asn Ser Ser Gly Val 
                165                 170                 175     


Glu Glu Arg Ile Glu Asn Ile Tyr Ser Arg His Lys Ile Tyr Lys Leu 
            180                 185                 190         


Ser Pro Glu Thr Thr Tyr Cys Leu Lys Val Lys Ala Ala Leu Leu Thr 
        195                 200                 205             


Ser Trp Lys Ile Gly Val Tyr Ser Pro Val His Cys Ile Lys Thr Thr 
    210                 215                 220                 


Val Glu Asn Glu Leu Pro Pro Pro Glu Asn Ile Glu Val Ser Val Gln 
225                 230                 235                 240 


Asn Gln Asn Tyr Val Leu Lys Trp Asp Tyr Thr Tyr Ala Asn Met Thr 
                245                 250                 255     


Phe Gln Val Gln Trp Leu His Ala Phe Leu Lys Arg Asn Pro Gly Asn 
            260                 265                 270         


His Leu Tyr Lys Trp Lys Gln Ile Pro Asp Cys Glu Asn Val Lys Thr 
        275                 280                 285             


Thr Gln Cys Val Phe Pro Gln Asn Val Phe Gln Lys Gly Ile Tyr Leu 
    290                 295                 300                 


Leu Arg Val Gln Ala Ser Asp Gly Asn Asn Thr Ser Phe Trp Ser Glu 
305                 310                 315                 320 


Glu Ile Lys Phe Asp Thr Glu Ile Gln Ala Phe Leu Leu Pro Pro Val 
                325                 330                 335     


Phe Asn Ile Arg Ser Leu Ser Asp Ser Phe His Ile Tyr Ile Gly Ala 
            340                 345                 350         


Pro Lys Gln Ser Gly Asn Thr Pro Val Ile Gln Asp Tyr Pro Leu Ile 
        355                 360                 365             


Tyr Glu Ile Ile Phe Trp Glu Asn Thr Ser Asn Ala Glu Arg Lys Ile 
    370                 375                 380                 


Ile Glu Lys Lys Thr Asp Val Thr Val Pro Asn Leu Lys Pro Leu Thr 
385                 390                 395                 400 


Val Tyr Cys Val Lys Ala Arg Ala His Thr Met Asp Glu Lys Leu Asn 
                405                 410                 415     


Lys Ser Ser Val Phe Ser Asp Ala Val Cys Glu Lys Thr Lys Pro Gly 
            420                 425                 430         


Asn Thr Ser Lys Ile Trp Leu Ile Val Gly Ile Cys Ile Ala Leu Phe 
        435                 440                 445             


Ala Leu Pro Phe Val Ile Tyr Ala Ala Lys Val Phe Leu Arg Cys Ile 
    450                 455                 460                 


Asn Tyr Val Phe Phe Pro Ser Leu Lys Pro Ser Ser Ser Ile Asp Glu 
465                 470                 475                 480 


Tyr Phe Ser Glu Gln Pro Leu Lys Asn Leu Leu Leu Ser Thr Ser Glu 
                485                 490                 495     


Glu Gln Ile Glu Lys Cys Phe Ile Ile Glu Asn Ile Ser Thr Ile Ala 
            500                 505                 510         


Thr Val Glu Glu Thr Asn Gln Thr Asp Glu Asp His Lys Lys Tyr Ser 
        515                 520                 525             


Ser Gln Thr Ser Gln Asp Ser Gly Asn Tyr Ser Asn Glu Asp Glu Ser 
    530                 535                 540                 


Glu Ser Lys Thr Ser Glu Glu Leu Gln Gln Asp Phe Val 
545                 550                 555         


<210>  6741
<211>  136
<212>  PRT
<213>  Homo Sapiens

<400>  6741

Met Met Val Val Leu Leu Gly Ala Thr Thr Leu Val Leu Val Ala Val 
1               5                   10                  15      


Ala Pro Trp Val Leu Ser Ala Ala Ala Gly Gly Lys Asn Leu Lys Ser 
            20                  25                  30          


Pro Gln Lys Val Glu Val Asp Ile Ile Asp Asp Asn Phe Ile Leu Arg 
        35                  40                  45              


Trp Asn Arg Ser Asp Glu Ser Val Gly Asn Val Thr Phe Ser Phe Asp 
    50                  55                  60                  


Tyr Gln Lys Thr Gly Met Asp Asn Trp Ile Lys Leu Ser Gly Cys Gln 
65                  70                  75                  80  


Asn Ile Thr Ser Thr Lys Cys Asn Phe Ser Ser Leu Lys Leu Asn Val 
                85                  90                  95      


Tyr Glu Glu Ile Lys Leu Arg Ile Arg Ala Glu Lys Glu Asn Thr Ser 
            100                 105                 110         


Ser Trp Tyr Glu Val Asp Ser Phe Thr Pro Phe Arg Lys Val Glu Asn 
        115                 120                 125             


Glu Leu Pro Pro Pro Glu Asn Ile 
    130                 135     


<210>  6742
<211>  187
<212>  PRT
<213>  Homo Sapiens

<400>  6742

Met Thr Asn Lys Cys Leu Leu Gln Ile Ala Leu Leu Leu Cys Phe Ser 
1               5                   10                  15      


Thr Thr Ala Leu Ser Met Ser Tyr Asn Leu Leu Gly Phe Leu Gln Arg 
            20                  25                  30          


Ser Ser Asn Phe Gln Cys Gln Lys Leu Leu Trp Gln Leu Asn Gly Arg 
        35                  40                  45              


Leu Glu Tyr Cys Leu Lys Asp Arg Met Asn Phe Asp Ile Pro Glu Glu 
    50                  55                  60                  


Ile Lys Gln Leu Gln Gln Phe Gln Lys Glu Asp Ala Ala Leu Thr Ile 
65                  70                  75                  80  


Tyr Glu Met Leu Gln Asn Ile Phe Ala Ile Phe Arg Gln Asp Ser Ser 
                85                  90                  95      


Ser Thr Gly Trp Asn Glu Thr Ile Val Glu Asn Leu Leu Ala Asn Val 
            100                 105                 110         


Tyr His Gln Ile Asn His Leu Lys Thr Val Leu Glu Glu Lys Leu Glu 
        115                 120                 125             


Lys Glu Asp Phe Thr Arg Gly Lys Leu Met Ser Ser Leu His Leu Lys 
    130                 135                 140                 


Arg Tyr Tyr Gly Arg Ile Leu His Tyr Leu Lys Ala Lys Glu Tyr Ser 
145                 150                 155                 160 


His Cys Ala Trp Thr Ile Val Arg Val Glu Ile Leu Arg Asn Phe Tyr 
                165                 170                 175     


Phe Ile Asn Arg Leu Thr Gly Tyr Leu Arg Asn 
            180                 185         


<210>  6743
<211>  208
<212>  PRT
<213>  Homo Sapiens

<400>  6743

Met Ile Ile Lys His Phe Phe Gly Thr Val Leu Val Leu Leu Ala Ser 
1               5                   10                  15      


Thr Thr Ile Phe Ser Leu Asp Leu Lys Leu Ile Ile Phe Gln Gln Arg 
            20                  25                  30          


Gln Val Asn Gln Glu Ser Leu Lys Leu Leu Asn Lys Leu Gln Thr Leu 
        35                  40                  45              


Ser Ile Gln Gln Cys Leu Pro His Arg Lys Asn Phe Leu Leu Pro Gln 
    50                  55                  60                  


Lys Ser Leu Ser Pro Gln Gln Tyr Gln Lys Gly His Thr Leu Ala Ile 
65                  70                  75                  80  


Leu His Glu Met Leu Gln Gln Ile Phe Ser Leu Phe Arg Ala Asn Ile 
                85                  90                  95      


Ser Leu Asp Gly Trp Glu Glu Asn His Thr Glu Lys Phe Leu Ile Gln 
            100                 105                 110         


Leu His Gln Gln Leu Glu Tyr Leu Glu Ala Leu Met Gly Leu Glu Ala 
        115                 120                 125             


Glu Lys Leu Ser Gly Thr Leu Gly Ser Asp Asn Leu Arg Leu Gln Val 
    130                 135                 140                 


Lys Met Tyr Phe Arg Arg Ile His Asp Tyr Leu Glu Asn Gln Asp Tyr 
145                 150                 155                 160 


Ser Thr Cys Ala Trp Ala Ile Val Gln Val Glu Ile Ser Arg Cys Leu 
                165                 170                 175     


Phe Phe Val Phe Ser Leu Thr Glu Lys Leu Ser Lys Gln Gly Arg Pro 
            180                 185                 190         


Leu Asn Asp Met Lys Gln Glu Leu Thr Thr Glu Phe Arg Ser Pro Arg 
        195                 200                 205             


<210>  6744
<211>  166
<212>  PRT
<213>  Homo Sapiens

<400>  6744

Met Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu Cys Ile Val Leu 
1               5                   10                  15      


Gly Ser Leu Gly Cys Tyr Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu 
            20                  25                  30          


Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn 
        35                  40                  45              


Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp 
    50                  55                  60                  


Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe 
65                  70                  75                  80  


Lys Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile 
                85                  90                  95      


Lys Glu Asp Met Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg 
            100                 105                 110         


Asp Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val 
        115                 120                 125             


Gln Arg Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser 
    130                 135                 140                 


Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg 
145                 150                 155                 160 


Gly Arg Arg Ala Ser Gln 
                165     


<210>  6745
<211>  30
<212>  PRT
<213>  Homo Sapiens

<400>  6745

Leu Leu Pro Leu Val Met Gln Gly Val Ser Arg Ala Glu Met Gly Thr 
1               5                   10                  15      


Ala Asp Leu Gly Pro Ser Ser Val Leu Ser Thr Asp Val Phe 
            20                  25                  30  


<210>  6746
<211>  210
<212>  PRT
<213>  Homo Sapiens

<400>  6746

Met Ala Leu Leu Phe Leu Leu Pro Leu Val Met Gln Gly Val Ser Arg 
1               5                   10                  15      


Ala Glu Met Gly Thr Ala Asp Leu Gly Pro Ser Ser Val Pro Thr Pro 
            20                  25                  30          


Thr Asn Val Thr Ile Glu Ser Tyr Asn Met Asn Pro Ile Val Tyr Trp 
        35                  40                  45              


Glu Tyr Gln Ile Met Pro Gln Val Pro Val Phe Thr Val Glu Val Lys 
    50                  55                  60                  


Asn Tyr Gly Val Lys Ala Arg Val Gly Gln Lys Glu Ser Ala Tyr Ala 
65                  70                  75                  80  


Lys Ser Glu Glu Phe Ala Val Cys Arg Asp Gly Lys Ile Gly Pro Pro 
                85                  90                  95      


Lys Leu Asp Ile Arg Lys Glu Glu Lys Gln Ile Met Ile Asp Ile Phe 
            100                 105                 110         


His Pro Ser Val Phe Val Asn Gly Asp Glu Gln Glu Val Asp Tyr Asp 
        115                 120                 125             


Pro Glu Thr Thr Cys Tyr Ile Arg Val Tyr Asn Val Tyr Val Arg Met 
    130                 135                 140                 


Asn Gly Ser Glu Ile Gln Tyr Lys Ile Leu Thr Gln Lys Glu Asp Asp 
145                 150                 155                 160 


Cys Asp Glu Ile Gln Cys Gln Leu Ala Ile Pro Val Ser Ser Leu Asn 
                165                 170                 175     


Ser Gln Tyr Cys Val Ser Ala Glu Gly Val Leu His Val Trp Gly Val 
            180                 185                 190         


Thr Thr Glu Lys Ser Lys Glu Val Cys Ile Thr Ile Phe Asn Ser Ser 
        195                 200                 205             


Ile Lys 
    210 


<210>  6747
<211>  489
<212>  PRT
<213>  Homo Sapiens

<400>  6747

Met Ala Leu Leu Phe Leu Leu Pro Leu Val Met Gln Gly Val Ser Arg 
1               5                   10                  15      


Ala Glu Met Gly Thr Ala Asp Leu Gly Pro Ser Ser Val Pro Thr Pro 
            20                  25                  30          


Thr Asn Val Thr Ile Glu Ser Tyr Asn Met Asn Pro Ile Val Tyr Trp 
        35                  40                  45              


Glu Tyr Gln Ile Met Pro Gln Val Pro Val Phe Thr Val Glu Val Lys 
    50                  55                  60                  


Asn Tyr Gly Val Lys Asn Ser Glu Trp Ile Asp Ala Cys Ile Asn Ile 
65                  70                  75                  80  


Ser His His Tyr Cys Asn Ile Ser Asp His Val Gly Asp Pro Ser Asn 
                85                  90                  95      


Ser Leu Trp Val Arg Val Lys Ala Arg Val Gly Gln Lys Glu Ser Ala 
            100                 105                 110         


Tyr Ala Lys Ser Glu Glu Phe Ala Val Cys Arg Asp Gly Lys Ile Gly 
        115                 120                 125             


Pro Pro Lys Leu Asp Ile Arg Lys Glu Glu Lys Gln Ile Met Ile Asp 
    130                 135                 140                 


Ile Phe His Pro Ser Val Phe Val Asn Gly Asp Glu Gln Glu Val Asp 
145                 150                 155                 160 


Tyr Asp Pro Glu Thr Thr Cys Tyr Ile Arg Val Tyr Asn Val Tyr Val 
                165                 170                 175     


Arg Met Asn Gly Ser Glu Ile Gln Tyr Lys Ile Leu Thr Gln Lys Glu 
            180                 185                 190         


Asp Asp Cys Asp Glu Ile Gln Cys Gln Leu Ala Ile Pro Val Ser Ser 
        195                 200                 205             


Leu Asn Ser Gln Tyr Cys Val Ser Ala Glu Gly Val Leu His Val Trp 
    210                 215                 220                 


Gly Val Thr Thr Glu Lys Ser Lys Glu Val Cys Ile Thr Ile Phe Asn 
225                 230                 235                 240 


Ser Ser Ile Lys Gly Ser Leu Trp Ile Pro Val Val Ala Ala Leu Leu 
                245                 250                 255     


Leu Phe Leu Val Leu Ser Leu Val Phe Ile Cys Phe Tyr Ile Lys Lys 
            260                 265                 270         


Ile Asn Pro Leu Lys Glu Lys Ser Ile Ile Leu Pro Lys Ser Leu Ile 
        275                 280                 285             


Ser Val Val Arg Ser Ala Thr Leu Glu Thr Lys Pro Glu Ser Lys Tyr 
    290                 295                 300                 


Val Ser Leu Ile Thr Ser Tyr Gln Pro Phe Ser Leu Glu Lys Glu Val 
305                 310                 315                 320 


Val Cys Glu Glu Pro Leu Ser Pro Ala Thr Val Pro Gly Met His Thr 
                325                 330                 335     


Glu Asp Asn Pro Gly Lys Val Glu His Thr Glu Glu Leu Ser Ser Ile 
            340                 345                 350         


Thr Glu Val Val Thr Thr Glu Glu Asn Ile Pro Asp Val Val Pro Gly 
        355                 360                 365             


Ser His Leu Thr Pro Ile Glu Arg Glu Ser Ser Ser Pro Leu Ser Ser 
    370                 375                 380                 


Asn Gln Ser Glu Pro Gly Ser Ile Ala Leu Asn Ser Tyr His Ser Arg 
385                 390                 395                 400 


Asn Cys Ser Glu Ser Asp His Ser Arg Asn Gly Phe Asp Thr Asp Ser 
                405                 410                 415     


Ser Cys Leu Glu Ser His Ser Ser Leu Ser Asp Ser Glu Phe Pro Pro 
            420                 425                 430         


Asn Asn Lys Gly Glu Ile Lys Thr Glu Gly Gln Glu Leu Ile Thr Val 
        435                 440                 445             


Ile Lys Ala Pro Thr Ser Phe Gly Tyr Asp Lys Pro His Val Leu Val 
    450                 455                 460                 


Asp Leu Leu Val Asp Asp Ser Gly Lys Glu Ser Leu Ile Gly Tyr Arg 
465                 470                 475                 480 


Pro Thr Glu Asp Ser Lys Glu Phe Ser 
                485                 


<210>  6748
<211>  470
<212>  PRT
<213>  Homo Sapiens

<400>  6748

Met Cys Gly Ser Ile Val Gln Ser Leu Val Pro Thr Pro Thr Asn Val 
1               5                   10                  15      


Thr Ile Glu Ser Tyr Asn Met Asn Pro Ile Val Tyr Trp Glu Tyr Gln 
            20                  25                  30          


Ile Met Pro Gln Val Pro Val Phe Thr Val Glu Val Lys Asn Tyr Gly 
        35                  40                  45              


Val Lys Asn Ser Glu Trp Ile Asp Ala Cys Ile Asn Ile Ser His His 
    50                  55                  60                  


Tyr Cys Asn Ile Ser Asp His Val Gly Asp Pro Ser Asn Ser Leu Trp 
65                  70                  75                  80  


Val Arg Val Lys Ala Arg Val Gly Gln Lys Glu Ser Ala Tyr Ala Lys 
                85                  90                  95      


Ser Glu Glu Phe Ala Val Cys Arg Asp Gly Lys Ile Gly Pro Pro Lys 
            100                 105                 110         


Leu Asp Ile Arg Lys Glu Glu Lys Gln Ile Met Ile Asp Ile Phe His 
        115                 120                 125             


Pro Ser Val Phe Val Asn Gly Asp Glu Gln Glu Val Asp Tyr Asp Pro 
    130                 135                 140                 


Glu Thr Thr Cys Tyr Ile Arg Val Tyr Asn Val Tyr Val Arg Met Asn 
145                 150                 155                 160 


Gly Ser Glu Ile Gln Tyr Lys Ile Leu Thr Gln Lys Glu Asp Asp Cys 
                165                 170                 175     


Asp Glu Ile Gln Cys Gln Leu Ala Ile Pro Val Ser Ser Leu Asn Ser 
            180                 185                 190         


Gln Tyr Cys Val Ser Ala Glu Gly Val Leu His Val Trp Gly Val Thr 
        195                 200                 205             


Thr Glu Lys Ser Lys Glu Val Cys Ile Thr Ile Phe Asn Ser Ser Ile 
    210                 215                 220                 


Lys Gly Ser Leu Trp Ile Pro Val Val Ala Ala Leu Leu Leu Phe Leu 
225                 230                 235                 240 


Val Leu Ser Leu Val Phe Ile Cys Phe Tyr Ile Lys Lys Ile Asn Pro 
                245                 250                 255     


Leu Lys Glu Lys Ser Ile Ile Leu Pro Lys Ser Leu Ile Ser Val Val 
            260                 265                 270         


Arg Ser Ala Thr Leu Glu Thr Lys Pro Glu Ser Lys Tyr Val Ser Leu 
        275                 280                 285             


Ile Thr Ser Tyr Gln Pro Phe Ser Leu Glu Lys Glu Val Val Cys Glu 
    290                 295                 300                 


Glu Pro Leu Ser Pro Ala Thr Val Pro Gly Met His Thr Glu Asp Asn 
305                 310                 315                 320 


Pro Gly Lys Val Glu His Thr Glu Glu Leu Ser Ser Ile Thr Glu Val 
                325                 330                 335     


Val Thr Thr Glu Glu Asn Ile Pro Asp Val Val Pro Gly Ser His Leu 
            340                 345                 350         


Thr Pro Ile Glu Arg Glu Ser Ser Ser Pro Leu Ser Ser Asn Gln Ser 
        355                 360                 365             


Glu Pro Gly Ser Ile Ala Leu Asn Ser Tyr His Ser Arg Asn Cys Ser 
    370                 375                 380                 


Glu Ser Asp His Ser Arg Asn Gly Phe Asp Thr Asp Ser Ser Cys Leu 
385                 390                 395                 400 


Glu Ser His Ser Ser Leu Ser Asp Ser Glu Phe Pro Pro Asn Asn Lys 
                405                 410                 415     


Gly Glu Ile Lys Thr Glu Gly Gln Glu Leu Ile Thr Val Ile Lys Ala 
            420                 425                 430         


Pro Thr Ser Phe Gly Tyr Asp Lys Pro His Val Leu Val Asp Leu Leu 
        435                 440                 445             


Val Asp Asp Ser Gly Lys Glu Ser Leu Ile Gly Tyr Arg Pro Thr Glu 
    450                 455                 460                 


Asp Ser Lys Glu Phe Ser 
465                 470 


<210>  6749
<211>  161
<212>  PRT
<213>  Homo Sapiens

<400>  6749

Met Leu Leu Lys Ser Pro Glu Asn Ser Leu Leu Gln Phe Gln Phe Lys 
1               5                   10                  15      


Tyr Gly Val Pro Thr Pro Thr Asn Val Thr Ile Glu Ser Tyr Asn Met 
            20                  25                  30          


Asn Pro Ile Val Tyr Trp Glu Tyr Gln Ile Met Pro Gln Val Pro Val 
        35                  40                  45              


Phe Thr Val Glu Val Lys Asn Tyr Gly Val Lys Asn Ser Glu Trp Ile 
    50                  55                  60                  


Asp Ala Cys Ile Asn Ile Ser His His Tyr Cys Asn Ile Ser Asp His 
65                  70                  75                  80  


Val Gly Asp Pro Ser Asn Ser Leu Trp Val Arg Val Lys Ala Arg Val 
                85                  90                  95      


Gly Gln Lys Glu Ser Ala Tyr Ala Lys Ser Glu Glu Phe Ala Val Cys 
            100                 105                 110         


Arg Asp Gly Lys Ile Gly Pro Pro Lys Leu Asp Ile Arg Lys Glu Glu 
        115                 120                 125             


Lys Gln Ile Met Ile Asp Ile Phe His Pro Ser Val Phe Val Asn Gly 
    130                 135                 140                 


Asp Glu Gln Glu Val Asp Tyr Asp Pro Glu Thr Thr Cys Tyr Ile Arg 
145                 150                 155                 160 


Val 
    


<210>  6750
<211>  479
<212>  PRT
<213>  Homo Sapiens

<400>  6750

Met Leu Leu Lys Ser Pro Glu Asn Ser Leu Leu Gln Phe Gln Phe Lys 
1               5                   10                  15      


Tyr Gly Val Pro Thr Pro Thr Asn Val Thr Ile Glu Ser Tyr Asn Met 
            20                  25                  30          


Asn Pro Ile Val Tyr Trp Glu Tyr Gln Ile Met Pro Gln Val Pro Val 
        35                  40                  45              


Phe Thr Val Glu Val Lys Asn Tyr Gly Val Lys Asn Ser Glu Trp Ile 
    50                  55                  60                  


Asp Ala Cys Ile Asn Ile Ser His His Tyr Cys Asn Ile Ser Asp His 
65                  70                  75                  80  


Val Gly Asp Pro Ser Asn Ser Leu Trp Val Arg Val Lys Ala Arg Val 
                85                  90                  95      


Gly Gln Lys Glu Ser Ala Tyr Ala Lys Ser Glu Glu Phe Ala Val Cys 
            100                 105                 110         


Arg Asp Gly Lys Ile Gly Pro Pro Lys Leu Asp Ile Arg Lys Glu Glu 
        115                 120                 125             


Lys Gln Ile Met Ile Asp Ile Phe His Pro Ser Val Phe Val Asn Gly 
    130                 135                 140                 


Asp Glu Gln Glu Val Asp Tyr Asp Pro Glu Thr Thr Cys Tyr Ile Arg 
145                 150                 155                 160 


Val Tyr Asn Val Tyr Val Arg Met Asn Gly Ser Glu Ile Gln Tyr Lys 
                165                 170                 175     


Ile Leu Thr Gln Lys Glu Asp Asp Cys Asp Glu Ile Gln Cys Gln Leu 
            180                 185                 190         


Ala Ile Pro Val Ser Ser Leu Asn Ser Gln Tyr Cys Val Ser Ala Glu 
        195                 200                 205             


Gly Val Leu His Val Trp Gly Val Thr Thr Glu Lys Ser Lys Glu Val 
    210                 215                 220                 


Cys Ile Thr Ile Phe Asn Ser Ser Ile Lys Gly Ser Leu Trp Ile Pro 
225                 230                 235                 240 


Val Val Ala Ala Leu Leu Leu Phe Leu Val Leu Ser Leu Val Phe Ile 
                245                 250                 255     


Cys Phe Tyr Ile Lys Lys Ile Asn Pro Leu Lys Glu Lys Ser Ile Ile 
            260                 265                 270         


Leu Pro Lys Ser Leu Ile Ser Val Val Arg Ser Ala Thr Leu Glu Thr 
        275                 280                 285             


Lys Pro Glu Ser Lys Tyr Val Ser Leu Ile Thr Ser Tyr Gln Pro Phe 
    290                 295                 300                 


Ser Leu Glu Lys Glu Val Val Cys Glu Glu Pro Leu Ser Pro Ala Thr 
305                 310                 315                 320 


Val Pro Gly Met His Thr Glu Asp Asn Pro Gly Lys Val Glu His Thr 
                325                 330                 335     


Glu Glu Leu Ser Ser Ile Thr Glu Val Val Thr Thr Glu Glu Asn Ile 
            340                 345                 350         


Pro Asp Val Val Pro Gly Ser His Leu Thr Pro Ile Glu Arg Glu Ser 
        355                 360                 365             


Ser Ser Pro Leu Ser Ser Asn Gln Ser Glu Pro Gly Ser Ile Ala Leu 
    370                 375                 380                 


Asn Ser Tyr His Ser Arg Asn Cys Ser Glu Ser Asp His Ser Arg Asn 
385                 390                 395                 400 


Gly Phe Asp Thr Asp Ser Ser Cys Leu Glu Ser His Ser Ser Leu Ser 
                405                 410                 415     


Asp Ser Glu Phe Pro Pro Asn Asn Lys Gly Glu Ile Lys Thr Glu Gly 
            420                 425                 430         


Gln Glu Leu Ile Thr Val Ile Lys Ala Pro Thr Ser Phe Gly Tyr Asp 
        435                 440                 445             


Lys Pro His Val Leu Val Asp Leu Leu Val Asp Asp Ser Gly Lys Glu 
    450                 455                 460                 


Ser Leu Ile Gly Tyr Arg Pro Thr Glu Asp Ser Lys Glu Phe Ser 
465                 470                 475                 


<210>  6751
<211>  479
<212>  PRT
<213>  Homo Sapiens

<400>  6751

Met Leu Leu Lys Ser Pro Glu Asn Ser Leu Leu Gln Phe Gln Phe Lys 
1               5                   10                  15      


Tyr Gly Val Pro Thr Pro Thr Asn Val Thr Ile Glu Ser Tyr Asn Met 
            20                  25                  30          


Asn Pro Ile Val Tyr Trp Glu Tyr Gln Ile Met Pro Gln Val Pro Val 
        35                  40                  45              


Phe Thr Val Glu Val Lys Asn Tyr Gly Val Lys Asn Ser Glu Trp Ile 
    50                  55                  60                  


Asp Ala Cys Ile Asn Ile Ser His His Tyr Cys Asn Ile Ser Asp His 
65                  70                  75                  80  


Val Gly Asp Pro Ser Asn Ser Leu Trp Val Arg Val Lys Ala Arg Val 
                85                  90                  95      


Gly Gln Lys Glu Ser Ala Tyr Ala Lys Ser Glu Glu Phe Ala Val Cys 
            100                 105                 110         


Arg Asp Gly Lys Ile Gly Pro Pro Lys Leu Asp Ile Arg Lys Glu Glu 
        115                 120                 125             


Lys Gln Ile Met Ile Asp Ile Phe His Pro Ser Val Phe Val Asn Gly 
    130                 135                 140                 


Asp Glu Gln Glu Val Asp Tyr Asp Pro Glu Thr Thr Cys Tyr Ile Arg 
145                 150                 155                 160 


Val Tyr Asn Val Tyr Val Arg Met Asn Gly Ser Glu Ile Gln Tyr Lys 
                165                 170                 175     


Ile Leu Thr Gln Lys Glu Asp Asp Cys Asp Glu Ile Gln Cys Gln Leu 
            180                 185                 190         


Ala Ile Pro Val Ser Ser Leu Asn Ser Gln Tyr Cys Val Ser Ala Glu 
        195                 200                 205             


Gly Val Leu His Val Trp Gly Val Thr Thr Glu Lys Ser Lys Glu Val 
    210                 215                 220                 


Cys Ile Thr Ile Phe Asn Ser Ser Ile Lys Gly Ser Leu Trp Ile Pro 
225                 230                 235                 240 


Val Val Ala Ala Leu Leu Leu Phe Leu Val Leu Ser Leu Val Phe Ile 
                245                 250                 255     


Cys Phe Tyr Ile Lys Lys Ile Asn Pro Leu Lys Glu Lys Ser Ile Ile 
            260                 265                 270         


Leu Pro Lys Ser Leu Ile Ser Val Val Arg Ser Ala Thr Leu Glu Thr 
        275                 280                 285             


Lys Pro Glu Ser Lys Tyr Val Ser Leu Ile Thr Ser Tyr Gln Pro Phe 
    290                 295                 300                 


Ser Leu Glu Lys Glu Val Val Cys Glu Glu Pro Leu Ser Pro Ala Thr 
305                 310                 315                 320 


Val Pro Gly Met His Thr Glu Asp Asn Pro Gly Lys Val Glu His Thr 
                325                 330                 335     


Glu Glu Leu Ser Ser Ile Thr Glu Val Val Thr Thr Glu Glu Asn Ile 
            340                 345                 350         


Pro Asp Val Val Pro Gly Ser His Leu Thr Pro Ile Glu Arg Glu Ser 
        355                 360                 365             


Ser Ser Pro Leu Ser Ser Asn Gln Ser Glu Pro Gly Ser Ile Ala Leu 
    370                 375                 380                 


Asn Ser Tyr His Ser Arg Asn Cys Ser Glu Ser Asp His Ser Arg Asn 
385                 390                 395                 400 


Gly Phe Asp Thr Asp Ser Ser Cys Leu Glu Ser His Ser Ser Leu Ser 
                405                 410                 415     


Asp Ser Glu Phe Pro Pro Asn Asn Lys Gly Glu Ile Lys Thr Glu Gly 
            420                 425                 430         


Gln Glu Leu Ile Thr Val Ile Lys Ala Pro Thr Ser Phe Gly Tyr Asp 
        435                 440                 445             


Lys Pro His Val Leu Val Asp Leu Leu Val Asp Asp Ser Gly Lys Glu 
    450                 455                 460                 


Ser Leu Ile Gly Tyr Arg Pro Thr Glu Asp Ser Lys Glu Phe Ser 
465                 470                 475                 


<210>  6752
<211>  448
<212>  PRT
<213>  Homo Sapiens

<400>  6752

Met Asn Pro Ile Val Tyr Trp Glu Tyr Gln Ile Met Pro Gln Val Pro 
1               5                   10                  15      


Val Phe Thr Val Glu Val Lys Asn Tyr Gly Val Lys Asn Ser Glu Trp 
            20                  25                  30          


Ile Asp Ala Cys Ile Asn Ile Ser His His Tyr Cys Asn Ile Ser Asp 
        35                  40                  45              


His Val Gly Asp Pro Ser Asn Ser Leu Trp Val Arg Val Lys Ala Arg 
    50                  55                  60                  


Val Gly Gln Lys Glu Ser Ala Tyr Ala Lys Ser Glu Glu Phe Ala Val 
65                  70                  75                  80  


Cys Arg Asp Gly Lys Ile Gly Pro Pro Lys Leu Asp Ile Arg Lys Glu 
                85                  90                  95      


Glu Lys Gln Ile Met Ile Asp Ile Phe His Pro Ser Val Phe Val Asn 
            100                 105                 110         


Gly Asp Glu Gln Glu Val Asp Tyr Asp Pro Glu Thr Thr Cys Tyr Ile 
        115                 120                 125             


Arg Val Tyr Asn Val Tyr Val Arg Met Asn Gly Ser Glu Ile Gln Tyr 
    130                 135                 140                 


Lys Ile Leu Thr Gln Lys Glu Asp Asp Cys Asp Glu Ile Gln Cys Gln 
145                 150                 155                 160 


Leu Ala Ile Pro Val Ser Ser Leu Asn Ser Gln Tyr Cys Val Ser Ala 
                165                 170                 175     


Glu Gly Val Leu His Val Trp Gly Val Thr Thr Glu Lys Ser Lys Glu 
            180                 185                 190         


Val Cys Ile Thr Ile Phe Asn Ser Ser Ile Lys Gly Ser Leu Trp Ile 
        195                 200                 205             


Pro Val Val Ala Ala Leu Leu Leu Phe Leu Val Leu Ser Leu Val Phe 
    210                 215                 220                 


Ile Cys Phe Tyr Ile Lys Lys Ile Asn Pro Leu Lys Glu Lys Ser Ile 
225                 230                 235                 240 


Ile Leu Pro Lys Ser Leu Ile Ser Val Val Arg Ser Ala Thr Leu Glu 
                245                 250                 255     


Thr Lys Pro Glu Ser Lys Tyr Val Ser Leu Ile Thr Ser Tyr Gln Pro 
            260                 265                 270         


Phe Ser Leu Glu Lys Glu Val Val Cys Glu Glu Pro Leu Ser Pro Ala 
        275                 280                 285             


Thr Val Pro Gly Met His Thr Glu Asp Asn Pro Gly Lys Val Glu His 
    290                 295                 300                 


Thr Glu Glu Leu Ser Ser Ile Thr Glu Val Val Thr Thr Glu Glu Asn 
305                 310                 315                 320 


Ile Pro Asp Val Val Pro Gly Ser His Leu Thr Pro Ile Glu Arg Glu 
                325                 330                 335     


Ser Ser Ser Pro Leu Ser Ser Asn Gln Ser Glu Pro Gly Ser Ile Ala 
            340                 345                 350         


Leu Asn Ser Tyr His Ser Arg Asn Cys Ser Glu Ser Asp His Ser Arg 
        355                 360                 365             


Asn Gly Phe Asp Thr Asp Ser Ser Cys Leu Glu Ser His Ser Ser Leu 
    370                 375                 380                 


Ser Asp Ser Glu Phe Pro Pro Asn Asn Lys Gly Glu Ile Lys Thr Glu 
385                 390                 395                 400 


Gly Gln Glu Leu Ile Thr Val Ile Lys Ala Pro Thr Ser Phe Gly Tyr 
                405                 410                 415     


Asp Lys Pro His Val Leu Val Asp Leu Leu Val Asp Asp Ser Gly Lys 
            420                 425                 430         


Glu Ser Leu Ile Gly Tyr Arg Pro Thr Glu Asp Ser Lys Glu Phe Ser 
        435                 440                 445             


<210>  6753
<211>  448
<212>  PRT
<213>  Homo Sapiens

<400>  6753

Met Asn Pro Ile Val Tyr Trp Glu Tyr Gln Ile Met Pro Gln Val Pro 
1               5                   10                  15      


Val Phe Thr Val Glu Val Lys Asn Tyr Gly Val Lys Asn Ser Glu Trp 
            20                  25                  30          


Ile Asp Ala Cys Ile Asn Ile Ser His His Tyr Cys Asn Ile Ser Asp 
        35                  40                  45              


His Val Gly Asp Pro Ser Asn Ser Leu Trp Val Arg Val Lys Ala Arg 
    50                  55                  60                  


Val Gly Gln Lys Glu Ser Ala Tyr Ala Lys Ser Glu Glu Phe Ala Val 
65                  70                  75                  80  


Cys Arg Asp Gly Lys Ile Gly Pro Pro Lys Leu Asp Ile Arg Lys Glu 
                85                  90                  95      


Glu Lys Gln Ile Met Ile Asp Ile Phe His Pro Ser Val Phe Val Asn 
            100                 105                 110         


Gly Asp Glu Gln Glu Val Asp Tyr Asp Pro Glu Thr Thr Cys Tyr Ile 
        115                 120                 125             


Arg Val Tyr Asn Val Tyr Val Arg Met Asn Gly Ser Glu Ile Gln Tyr 
    130                 135                 140                 


Lys Ile Leu Thr Gln Lys Glu Asp Asp Cys Asp Glu Ile Gln Cys Gln 
145                 150                 155                 160 


Leu Ala Ile Pro Val Ser Ser Leu Asn Ser Gln Tyr Cys Val Ser Ala 
                165                 170                 175     


Glu Gly Val Leu His Val Trp Gly Val Thr Thr Glu Lys Ser Lys Glu 
            180                 185                 190         


Val Cys Ile Thr Ile Phe Asn Ser Ser Ile Lys Gly Ser Leu Trp Ile 
        195                 200                 205             


Pro Val Val Ala Ala Leu Leu Leu Phe Leu Val Leu Ser Leu Val Phe 
    210                 215                 220                 


Ile Cys Phe Tyr Ile Lys Lys Ile Asn Pro Leu Lys Glu Lys Ser Ile 
225                 230                 235                 240 


Ile Leu Pro Lys Ser Leu Ile Ser Val Val Arg Ser Ala Thr Leu Glu 
                245                 250                 255     


Thr Lys Pro Glu Ser Lys Tyr Val Ser Leu Ile Thr Ser Tyr Gln Pro 
            260                 265                 270         


Phe Ser Leu Glu Lys Glu Val Val Cys Glu Glu Pro Leu Ser Pro Ala 
        275                 280                 285             


Thr Val Pro Gly Met His Thr Glu Asp Asn Pro Gly Lys Val Glu His 
    290                 295                 300                 


Thr Glu Glu Leu Ser Ser Ile Thr Glu Val Val Thr Thr Glu Glu Asn 
305                 310                 315                 320 


Ile Pro Asp Val Val Pro Gly Ser His Leu Thr Pro Ile Glu Arg Glu 
                325                 330                 335     


Ser Ser Ser Pro Leu Ser Ser Asn Gln Ser Glu Pro Gly Ser Ile Ala 
            340                 345                 350         


Leu Asn Ser Tyr His Ser Arg Asn Cys Ser Glu Ser Asp His Ser Arg 
        355                 360                 365             


Asn Gly Phe Asp Thr Asp Ser Ser Cys Leu Glu Ser His Ser Ser Leu 
    370                 375                 380                 


Ser Asp Ser Glu Phe Pro Pro Asn Asn Lys Gly Glu Ile Lys Thr Glu 
385                 390                 395                 400 


Gly Gln Glu Leu Ile Thr Val Ile Lys Ala Pro Thr Ser Phe Gly Tyr 
                405                 410                 415     


Asp Lys Pro His Val Leu Val Asp Leu Leu Val Asp Asp Ser Gly Lys 
            420                 425                 430         


Glu Ser Leu Ile Gly Tyr Arg Pro Thr Glu Asp Ser Lys Glu Phe Ser 
        435                 440                 445             


<210>  6754
<211>  448
<212>  PRT
<213>  Homo Sapiens

<400>  6754

Met Asn Pro Ile Val Tyr Trp Glu Tyr Gln Ile Met Pro Gln Val Pro 
1               5                   10                  15      


Val Phe Thr Val Glu Val Lys Asn Tyr Gly Val Lys Asn Ser Glu Trp 
            20                  25                  30          


Ile Asp Ala Cys Ile Asn Ile Ser His His Tyr Cys Asn Ile Ser Asp 
        35                  40                  45              


His Val Gly Asp Pro Ser Asn Ser Leu Trp Val Arg Val Lys Ala Arg 
    50                  55                  60                  


Val Gly Gln Lys Glu Ser Ala Tyr Ala Lys Ser Glu Glu Phe Ala Val 
65                  70                  75                  80  


Cys Arg Asp Gly Lys Ile Gly Pro Pro Lys Leu Asp Ile Arg Lys Glu 
                85                  90                  95      


Glu Lys Gln Ile Met Ile Asp Ile Phe His Pro Ser Val Phe Val Asn 
            100                 105                 110         


Gly Asp Glu Gln Glu Val Asp Tyr Asp Pro Glu Thr Thr Cys Tyr Ile 
        115                 120                 125             


Arg Val Tyr Asn Val Tyr Val Arg Met Asn Gly Ser Glu Ile Gln Tyr 
    130                 135                 140                 


Lys Ile Leu Thr Gln Lys Glu Asp Asp Cys Asp Glu Ile Gln Cys Gln 
145                 150                 155                 160 


Leu Ala Ile Pro Val Ser Ser Leu Asn Ser Gln Tyr Cys Val Ser Ala 
                165                 170                 175     


Glu Gly Val Leu His Val Trp Gly Val Thr Thr Glu Lys Ser Lys Glu 
            180                 185                 190         


Val Cys Ile Thr Ile Phe Asn Ser Ser Ile Lys Gly Ser Leu Trp Ile 
        195                 200                 205             


Pro Val Val Ala Ala Leu Leu Leu Phe Leu Val Leu Ser Leu Val Phe 
    210                 215                 220                 


Ile Cys Phe Tyr Ile Lys Lys Ile Asn Pro Leu Lys Glu Lys Ser Ile 
225                 230                 235                 240 


Ile Leu Pro Lys Ser Leu Ile Ser Val Val Arg Ser Ala Thr Leu Glu 
                245                 250                 255     


Thr Lys Pro Glu Ser Lys Tyr Val Ser Leu Ile Thr Ser Tyr Gln Pro 
            260                 265                 270         


Phe Ser Leu Glu Lys Glu Val Val Cys Glu Glu Pro Leu Ser Pro Ala 
        275                 280                 285             


Thr Val Pro Gly Met His Thr Glu Asp Asn Pro Gly Lys Val Glu His 
    290                 295                 300                 


Thr Glu Glu Leu Ser Ser Ile Thr Glu Val Val Thr Thr Glu Glu Asn 
305                 310                 315                 320 


Ile Pro Asp Val Val Pro Gly Ser His Leu Thr Pro Ile Glu Arg Glu 
                325                 330                 335     


Ser Ser Ser Pro Leu Ser Ser Asn Gln Ser Glu Pro Gly Ser Ile Ala 
            340                 345                 350         


Leu Asn Ser Tyr His Ser Arg Asn Cys Ser Glu Ser Asp His Ser Arg 
        355                 360                 365             


Asn Gly Phe Asp Thr Asp Ser Ser Cys Leu Glu Ser His Ser Ser Leu 
    370                 375                 380                 


Ser Asp Ser Glu Phe Pro Pro Asn Asn Lys Gly Glu Ile Lys Thr Glu 
385                 390                 395                 400 


Gly Gln Glu Leu Ile Thr Val Ile Lys Ala Pro Thr Ser Phe Gly Tyr 
                405                 410                 415     


Asp Lys Pro His Val Leu Val Asp Leu Leu Val Asp Asp Ser Gly Lys 
            420                 425                 430         


Glu Ser Leu Ile Gly Tyr Arg Pro Thr Glu Asp Ser Lys Glu Phe Ser 
        435                 440                 445             


<210>  6755
<211>  27
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6755

Xaa Leu Leu Pro Leu Val Met Gln Gly Val Ser Arg Ala Glu Met Gly 
1               5                   10                  15      


Thr Ala Asp Leu Gly Pro Ser Ser Asp Val Phe 
            20                  25          


<210>  6756
<211>  200
<212>  PRT
<213>  Homo Sapiens

<400>  6756

Met Ala Ala Ala Trp Thr Val Val Leu Val Thr Leu Val Leu Gly Leu 
1               5                   10                  15      


Ala Val Ala Gly Pro Val Pro Thr Ser Lys Pro Thr Thr Thr Gly Lys 
            20                  25                  30          


Gly Cys His Ile Gly Arg Phe Lys Ser Leu Ser Pro Gln Glu Leu Ala 
        35                  40                  45              


Ser Phe Lys Lys Ala Arg Asp Ala Leu Glu Glu Ser Leu Lys Leu Lys 
    50                  55                  60                  


Asn Trp Ser Cys Ser Ser Pro Val Phe Pro Gly Asn Trp Asp Leu Arg 
65                  70                  75                  80  


Leu Leu Gln Val Arg Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala 
                85                  90                  95      


Leu Thr Leu Lys Val Leu Glu Ala Ala Ala Gly Pro Ala Leu Glu Asp 
            100                 105                 110         


Val Leu Asp Gln Pro Leu His Thr Leu His His Ile Leu Ser Gln Leu 
        115                 120                 125             


Gln Ala Cys Ile Gln Pro Gln Pro Thr Ala Gly Pro Arg Pro Arg Gly 
    130                 135                 140                 


Arg Leu His His Trp Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu 
145                 150                 155                 160 


Ser Ala Gly Cys Leu Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu 
                165                 170                 175     


Leu Thr Arg Asp Leu Lys Tyr Val Ala Asp Gly Asn Leu Cys Leu Arg 
            180                 185                 190         


Thr Ser Thr His Pro Glu Ser Thr 
        195                 200 


<210>  6757
<211>  200
<212>  PRT
<213>  Homo Sapiens

<400>  6757

Met Lys Leu Asp Met Thr Gly Asp Cys Thr Pro Val Leu Val Leu Met 
1               5                   10                  15      


Ala Ala Val Leu Thr Val Thr Gly Ala Val Pro Val Ala Arg Leu His 
            20                  25                  30          


Gly Ala Leu Pro Asp Ala Arg Gly Cys His Ile Ala Gln Phe Lys Ser 
        35                  40                  45              


Leu Ser Pro Gln Glu Leu Gln Ala Phe Lys Arg Ala Lys Asp Ala Leu 
    50                  55                  60                  


Glu Glu Ser Leu Leu Leu Lys Asp Cys Arg Cys His Ser Arg Leu Phe 
65                  70                  75                  80  


Pro Arg Thr Trp Asp Leu Arg Gln Leu Gln Val Arg Glu Arg Pro Met 
                85                  90                  95      


Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu Lys Val Leu Glu Ala Thr 
            100                 105                 110         


Ala Asp Thr Asp Pro Ala Leu Val Asp Val Leu Asp Gln Pro Leu His 
        115                 120                 125             


Thr Leu His His Ile Leu Ser Gln Phe Arg Ala Cys Ile Gln Pro Gln 
    130                 135                 140                 


Pro Thr Ala Gly Pro Arg Thr Arg Gly Arg Leu His His Trp Leu Tyr 
145                 150                 155                 160 


Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser Pro Gly Cys Leu Glu Ala 
                165                 170                 175     


Ser Val Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu Asn Cys 
            180                 185                 190         


Val Ala Ser Gly Asp Leu Cys Val 
        195                 200 


<210>  6758
<211>  200
<212>  PRT
<213>  Homo Sapiens

<400>  6758

Met Lys Leu Asp Met Thr Gly Asp Cys Met Pro Val Leu Val Leu Met 
1               5                   10                  15      


Ala Ala Val Leu Thr Val Thr Gly Ala Val Pro Val Ala Arg Leu Arg 
            20                  25                  30          


Gly Ala Leu Pro Asp Ala Arg Gly Cys His Ile Ala Gln Phe Lys Ser 
        35                  40                  45              


Leu Ser Pro Gln Glu Leu Gln Ala Phe Lys Arg Ala Lys Asp Ala Leu 
    50                  55                  60                  


Glu Glu Ser Leu Leu Leu Lys Asp Cys Lys Cys Arg Ser Arg Leu Phe 
65                  70                  75                  80  


Pro Arg Thr Trp Asp Leu Arg Gln Leu Gln Val Arg Glu Arg Pro Val 
                85                  90                  95      


Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu Lys Val Leu Glu Ala Thr 
            100                 105                 110         


Ala Asp Thr Asp Pro Ala Leu Gly Asp Val Leu Asp Gln Pro Leu His 
        115                 120                 125             


Thr Leu His His Ile Leu Ser Gln Leu Arg Ala Cys Ile Gln Pro Gln 
    130                 135                 140                 


Pro Thr Ala Gly Pro Arg Thr Arg Gly Arg Leu His His Trp Leu His 
145                 150                 155                 160 


Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser Pro Gly Cys Leu Glu Ala 
                165                 170                 175     


Ser Val Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu Asn Cys 
            180                 185                 190         


Val Ala Ser Gly Asp Leu Cys Val 
        195                 200 


<210>  6759
<211>  196
<212>  PRT
<213>  Homo Sapiens

<400>  6759

Met Thr Gly Asp Cys Met Pro Val Leu Val Leu Met Ala Ala Val Leu 
1               5                   10                  15      


Thr Val Thr Gly Ala Val Pro Val Ala Arg Leu Arg Gly Ala Leu Pro 
            20                  25                  30          


Asp Ala Arg Gly Cys His Ile Ala Gln Phe Lys Ser Leu Ser Pro Gln 
        35                  40                  45              


Glu Leu Gln Ala Phe Lys Arg Ala Lys Asp Ala Leu Glu Glu Ser Leu 
    50                  55                  60                  


Leu Leu Lys Asp Cys Lys Cys Arg Ser Arg Leu Phe Pro Arg Thr Trp 
65                  70                  75                  80  


Asp Leu Arg Gln Leu Gln Val Arg Glu Arg Pro Val Ala Leu Glu Ala 
                85                  90                  95      


Glu Leu Ala Leu Thr Leu Lys Val Leu Glu Ala Thr Ala Asp Thr Asp 
            100                 105                 110         


Pro Ala Leu Gly Asp Val Leu Asp Gln Pro Leu His Thr Leu His His 
        115                 120                 125             


Ile Leu Ser Gln Leu Arg Ala Cys Ile Gln Pro Gln Pro Thr Ala Gly 
    130                 135                 140                 


Pro Arg Thr Arg Gly Arg Leu His His Trp Leu His Arg Leu Gln Glu 
145                 150                 155                 160 


Ala Pro Lys Lys Glu Ser Pro Gly Cys Leu Glu Ala Ser Val Thr Phe 
                165                 170                 175     


Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu Asn Cys Val Ala Ser Gly 
            180                 185                 190         


Asp Leu Cys Val 
        195     


<210>  6760
<211>  520
<212>  PRT
<213>  Homo Sapiens

<400>  6760

Met Ala Gly Pro Glu Arg Trp Gly Pro Leu Leu Leu Cys Leu Leu Gln 
1               5                   10                  15      


Ala Ala Pro Gly Arg Pro Arg Leu Ala Pro Pro Gln Asn Val Thr Leu 
            20                  25                  30          


Leu Ser Gln Asn Phe Ser Val Tyr Leu Thr Trp Leu Pro Gly Leu Gly 
        35                  40                  45              


Asn Pro Gln Asp Val Thr Tyr Phe Val Ala Tyr Gln Ser Ser Pro Thr 
    50                  55                  60                  


Arg Arg Arg Trp Arg Glu Val Glu Glu Cys Ala Gly Thr Lys Glu Leu 
65                  70                  75                  80  


Leu Cys Ser Met Met Cys Leu Lys Lys Gln Asp Leu Tyr Asn Lys Phe 
                85                  90                  95      


Lys Gly Arg Val Arg Thr Val Ser Pro Ser Ser Lys Ser Pro Trp Val 
            100                 105                 110         


Glu Ser Glu Tyr Leu Asp Tyr Leu Phe Glu Val Glu Pro Ala Pro Pro 
        115                 120                 125             


Val Leu Val Leu Thr Gln Thr Glu Glu Ile Leu Ser Ala Asn Ala Thr 
    130                 135                 140                 


Tyr Gln Leu Pro Pro Cys Met Pro Pro Leu Asp Leu Lys Tyr Glu Val 
145                 150                 155                 160 


Ala Phe Trp Lys Glu Gly Ala Gly Asn Lys Thr Leu Phe Pro Val Thr 
                165                 170                 175     


Pro His Gly Gln Pro Val Gln Ile Thr Leu Gln Pro Ala Ala Ser Glu 
            180                 185                 190         


His His Cys Leu Ser Ala Arg Thr Ile Tyr Thr Phe Ser Val Pro Lys 
        195                 200                 205             


Tyr Ser Lys Phe Ser Lys Pro Thr Cys Phe Leu Leu Glu Val Pro Glu 
    210                 215                 220                 


Ala Asn Trp Ala Phe Leu Val Leu Pro Ser Leu Leu Ile Leu Leu Leu 
225                 230                 235                 240 


Val Ile Ala Ala Gly Gly Val Ile Trp Lys Thr Leu Met Gly Asn Pro 
                245                 250                 255     


Trp Phe Gln Arg Ala Lys Met Pro Arg Ala Leu Asp Phe Ser Gly His 
            260                 265                 270         


Thr His Pro Val Ala Thr Phe Gln Pro Ser Arg Pro Glu Ser Val Asn 
        275                 280                 285             


Asp Leu Phe Leu Cys Pro Gln Lys Glu Leu Thr Arg Gly Val Arg Pro 
    290                 295                 300                 


Thr Pro Arg Val Arg Ala Pro Ala Thr Gln Gln Thr Arg Trp Lys Lys 
305                 310                 315                 320 


Asp Leu Ala Glu Asp Glu Glu Glu Glu Asp Glu Glu Asp Thr Glu Asp 
                325                 330                 335     


Gly Val Ser Phe Gln Pro Tyr Ile Glu Pro Pro Ser Phe Leu Gly Gln 
            340                 345                 350         


Glu His Gln Ala Pro Gly His Ser Glu Ala Gly Gly Val Asp Ser Gly 
        355                 360                 365             


Arg Pro Arg Ala Pro Leu Val Pro Ser Glu Gly Ser Ser Ala Trp Asp 
    370                 375                 380                 


Ser Ser Asp Arg Ser Trp Ala Ser Thr Val Asp Ser Ser Trp Asp Arg 
385                 390                 395                 400 


Ala Gly Ser Ser Gly Tyr Leu Ala Glu Lys Gly Pro Gly Gln Gly Pro 
                405                 410                 415     


Gly Gly Asp Gly His Gln Glu Ser Leu Pro Pro Pro Glu Phe Ser Lys 
            420                 425                 430         


Asp Ser Gly Phe Leu Glu Glu Leu Pro Glu Asp Asn Leu Ser Ser Trp 
        435                 440                 445             


Ala Thr Trp Gly Thr Leu Pro Pro Glu Pro Asn Leu Val Pro Gly Gly 
    450                 455                 460                 


Pro Pro Val Ser Leu Gln Thr Leu Thr Phe Cys Trp Glu Ser Ser Pro 
465                 470                 475                 480 


Glu Glu Glu Glu Glu Ala Arg Glu Ser Glu Ile Glu Asp Ser Asp Ala 
                485                 490                 495     


Gly Ser Trp Gly Ala Glu Ser Thr Gln Arg Thr Glu Asp Arg Gly Arg 
            500                 505                 510         


Thr Leu Gly His Tyr Met Ala Arg 
        515                 520 


<210>  6761
<211>  491
<212>  PRT
<213>  Homo Sapiens

<400>  6761

Met Ala Gly Pro Glu Arg Trp Gly Pro Leu Leu Leu Cys Leu Leu Gln 
1               5                   10                  15      


Ala Ala Pro Gly Arg Pro Arg Leu Ala Pro Pro Gln Asn Val Thr Leu 
            20                  25                  30          


Leu Ser Gln Asn Phe Ser Val Tyr Leu Thr Trp Leu Pro Gly Leu Gly 
        35                  40                  45              


Asn Pro Gln Asp Val Thr Tyr Phe Val Ala Tyr Gln Ser Ser Pro Thr 
    50                  55                  60                  


Arg Arg Arg Trp Arg Glu Val Glu Glu Cys Ala Gly Thr Lys Glu Leu 
65                  70                  75                  80  


Leu Cys Ser Met Met Cys Leu Lys Lys Gln Asp Leu Tyr Asn Lys Phe 
                85                  90                  95      


Lys Gly Arg Val Arg Thr Val Ser Pro Ser Ser Lys Ser Pro Trp Val 
            100                 105                 110         


Glu Ser Glu Tyr Leu Asp Tyr Leu Phe Glu Val Glu Pro Ala Pro Pro 
        115                 120                 125             


Val Leu Val Leu Thr Gln Thr Glu Glu Ile Leu Ser Ala Asn Ala Thr 
    130                 135                 140                 


Tyr Gln Leu Pro Pro Cys Met Pro Pro Leu Asp Leu Lys Tyr Glu Val 
145                 150                 155                 160 


Ala Phe Trp Lys Glu Gly Ala Gly Asn Lys Thr Leu Phe Pro Val Thr 
                165                 170                 175     


Pro His Gly Gln Pro Val Gln Ile Thr Leu Gln Pro Ala Ala Ser Glu 
            180                 185                 190         


His His Cys Leu Ser Ala Arg Thr Ile Tyr Thr Phe Ser Val Pro Lys 
        195                 200                 205             


Tyr Ser Lys Phe Ser Lys Pro Thr Cys Phe Leu Leu Glu Val Pro Glu 
    210                 215                 220                 


Ala Asn Trp Ala Phe Leu Val Leu Pro Ser Leu Leu Ile Leu Leu Leu 
225                 230                 235                 240 


Val Ile Ala Ala Gly Gly Val Ile Trp Lys Thr Leu Met Gly Asn Pro 
                245                 250                 255     


Trp Phe Gln Arg Ala Lys Met Pro Arg Ala Leu Glu Leu Thr Arg Gly 
            260                 265                 270         


Val Arg Pro Thr Pro Arg Val Arg Ala Pro Ala Thr Gln Gln Thr Arg 
        275                 280                 285             


Trp Lys Lys Asp Leu Ala Glu Asp Glu Glu Glu Glu Asp Glu Glu Asp 
    290                 295                 300                 


Thr Glu Asp Gly Val Ser Phe Gln Pro Tyr Ile Glu Pro Pro Ser Phe 
305                 310                 315                 320 


Leu Gly Gln Glu His Gln Ala Pro Gly His Ser Glu Ala Gly Gly Val 
                325                 330                 335     


Asp Ser Gly Arg Pro Arg Ala Pro Leu Val Pro Ser Glu Gly Ser Ser 
            340                 345                 350         


Ala Trp Asp Ser Ser Asp Arg Ser Trp Ala Ser Thr Val Asp Ser Ser 
        355                 360                 365             


Trp Asp Arg Ala Gly Ser Ser Gly Tyr Leu Ala Glu Lys Gly Pro Gly 
    370                 375                 380                 


Gln Gly Pro Gly Gly Asp Gly His Gln Glu Ser Leu Pro Pro Pro Glu 
385                 390                 395                 400 


Phe Ser Lys Asp Ser Gly Phe Leu Glu Glu Leu Pro Glu Asp Asn Leu 
                405                 410                 415     


Ser Ser Trp Ala Thr Trp Gly Thr Leu Pro Pro Glu Pro Asn Leu Val 
            420                 425                 430         


Pro Gly Gly Pro Pro Val Ser Leu Gln Thr Leu Thr Phe Cys Trp Glu 
        435                 440                 445             


Ser Ser Pro Glu Glu Glu Glu Glu Ala Arg Glu Ser Glu Ile Glu Asp 
    450                 455                 460                 


Ser Asp Ala Gly Ser Trp Gly Ala Glu Ser Thr Gln Arg Thr Glu Asp 
465                 470                 475                 480 


Arg Gly Arg Thr Leu Gly His Tyr Met Ala Arg 
                485                 490     


<210>  6762
<211>  244
<212>  PRT
<213>  Homo Sapiens

<400>  6762

Met Ala Gly Pro Glu Arg Trp Gly Pro Leu Leu Leu Cys Leu Leu Gln 
1               5                   10                  15      


Ala Ala Pro Gly Arg Pro Arg Leu Ala Pro Pro Gln Asn Val Thr Leu 
            20                  25                  30          


Leu Ser Gln Asn Phe Ser Val Tyr Leu Thr Trp Leu Pro Gly Leu Gly 
        35                  40                  45              


Asn Pro Gln Asp Val Thr Tyr Phe Val Ala Tyr Gln Ser Ser Pro Thr 
    50                  55                  60                  


Arg Arg Arg Trp Arg Glu Val Glu Glu Cys Ala Gly Thr Lys Glu Leu 
65                  70                  75                  80  


Leu Cys Ser Met Met Cys Leu Lys Lys Gln Asp Leu Tyr Asn Lys Phe 
                85                  90                  95      


Lys Gly Arg Val Arg Thr Val Ser Pro Ser Ser Lys Ser Pro Trp Val 
            100                 105                 110         


Glu Ser Glu Tyr Leu Asp Tyr Leu Phe Glu Val Glu Pro Ala Pro Pro 
        115                 120                 125             


Val Leu Val Leu Thr Gln Thr Glu Glu Ile Leu Ser Ala Asn Ala Thr 
    130                 135                 140                 


Tyr Gln Leu Pro Pro Cys Met Pro Pro Leu Asp Leu Lys Tyr Glu Val 
145                 150                 155                 160 


Ala Phe Trp Lys Glu Gly Ala Gly Asn Lys Thr Leu Phe Pro Val Thr 
                165                 170                 175     


Pro His Gly Gln Pro Val Gln Ile Thr Leu Gln Pro Ala Ala Ser Glu 
            180                 185                 190         


His His Cys Leu Ser Ala Arg Thr Ile Tyr Thr Phe Ser Val Pro Lys 
        195                 200                 205             


Tyr Ser Lys Phe Ser Lys Pro Thr Cys Phe Leu Leu Glu Val Pro Gly 
    210                 215                 220                 


Leu Phe Trp Thr His Thr Pro Cys Gly Asn Leu Ser Ala Gln Gln Thr 
225                 230                 235                 240 


Arg Val Arg Glu 
                


<210>  6763
<211>  211
<212>  PRT
<213>  Homo Sapiens

<400>  6763

Met Ala Gly Pro Glu Arg Trp Gly Pro Leu Leu Leu Cys Leu Leu Gln 
1               5                   10                  15      


Ala Ala Pro Gly Arg Pro Arg Leu Ala Pro Pro Gln Asn Val Thr Leu 
            20                  25                  30          


Leu Ser Gln Asn Phe Ser Val Tyr Leu Thr Trp Leu Pro Gly Leu Gly 
        35                  40                  45              


Asn Pro Gln Asp Val Thr Tyr Phe Val Ala Tyr Gln Ser Ser Pro Thr 
    50                  55                  60                  


Arg Arg Arg Trp Arg Glu Val Glu Glu Cys Ala Gly Thr Lys Glu Leu 
65                  70                  75                  80  


Leu Cys Ser Met Met Cys Leu Lys Lys Gln Asp Leu Tyr Asn Lys Phe 
                85                  90                  95      


Lys Gly Arg Val Arg Thr Val Ser Pro Ser Ser Lys Ser Pro Trp Val 
            100                 105                 110         


Glu Ser Glu Tyr Leu Asp Tyr Leu Phe Glu Val Glu Pro Ala Pro Pro 
        115                 120                 125             


Val Leu Val Leu Thr Gln Thr Glu Glu Ile Leu Ser Ala Asn Ala Thr 
    130                 135                 140                 


Tyr Gln Leu Pro Pro Cys Met Pro Pro Leu Asp Leu Lys Tyr Glu Val 
145                 150                 155                 160 


Ala Phe Trp Lys Glu Gly Ala Gly Asn Lys Val Gly Ser Ser Phe Pro 
                165                 170                 175     


Ala Pro Arg Leu Gly Pro Leu Leu His Pro Phe Leu Leu Arg Phe Phe 
            180                 185                 190         


Ser Pro Ser Gln Pro Ala Pro Ala Pro Leu Leu Gln Glu Val Phe Pro 
        195                 200                 205             


Val His Ser 
    210     


<210>  6764
<211>  185
<212>  PRT
<213>  Homo Sapiens

<400>  6764

Met Met Cys Leu Lys Lys Gln Asp Leu Tyr Asn Lys Phe Lys Gly Arg 
1               5                   10                  15      


Val Arg Thr Val Ser Pro Ser Ser Lys Ser Pro Trp Val Glu Ser Glu 
            20                  25                  30          


Tyr Leu Asp Tyr Leu Phe Glu Val Glu Pro Ala Pro Pro Val Leu Val 
        35                  40                  45              


Leu Thr Gln Thr Glu Glu Ile Leu Ser Ala Asn Ala Thr Tyr Gln Leu 
    50                  55                  60                  


Pro Pro Cys Met Pro Pro Leu Asp Leu Lys Tyr Glu Val Ala Phe Trp 
65                  70                  75                  80  


Lys Glu Gly Ala Gly Asn Lys Thr Leu Phe Pro Val Thr Pro His Gly 
                85                  90                  95      


Gln Pro Val Gln Ile Thr Leu Gln Pro Ala Ala Ser Glu His His Cys 
            100                 105                 110         


Leu Ser Ala Arg Thr Ile Tyr Thr Phe Ser Val Pro Lys Tyr Ser Lys 
        115                 120                 125             


Phe Ser Lys Pro Thr Cys Phe Leu Leu Glu Val Pro Glu Ala Asn Trp 
    130                 135                 140                 


Ala Phe Leu Val Leu Pro Ser Leu Leu Ile Leu Leu Leu Val Ile Ala 
145                 150                 155                 160 


Ala Gly Gly Val Ile Trp Lys Thr Leu Met Gly Asn Pro Trp Phe Gln 
                165                 170                 175     


Arg Ala Lys Met Pro Arg Ala Leu Val 
            180                 185 


<210>  6765
<211>  195
<212>  PRT
<213>  Homo Sapiens

<400>  6765

Met Ala Leu Leu Phe Pro Leu Leu Ala Ala Leu Val Met Thr Ser Tyr 
1               5                   10                  15      


Ser Pro Val Gly Ser Leu Gly Cys Asp Leu Pro Gln Asn His Gly Leu 
            20                  25                  30          


Leu Ser Arg Asn Thr Leu Val Leu Leu His Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Pro Phe Leu Cys Leu Lys Asp Arg Arg Asp Phe Arg Phe Pro Gln Glu 
    50                  55                  60                  


Met Val Lys Gly Ser Gln Leu Gln Lys Ala His Val Met Ser Val Leu 
65                  70                  75                  80  


His Glu Met Leu Gln Gln Ile Phe Ser Leu Phe His Thr Glu Arg Ser 
                85                  90                  95      


Ser Ala Ala Trp Asn Met Thr Leu Leu Asp Gln Leu His Thr Gly Leu 
            100                 105                 110         


His Gln Gln Leu Gln His Leu Glu Thr Cys Leu Leu Gln Val Val Gly 
        115                 120                 125             


Glu Gly Glu Ser Ala Gly Ala Ile Ser Ser Pro Ala Leu Thr Leu Arg 
    130                 135                 140                 


Arg Tyr Phe Gln Gly Ile Arg Val Tyr Leu Lys Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Asp Cys Ala Trp Glu Val Val Arg Met Glu Ile Met Lys Ser Leu Phe 
                165                 170                 175     


Leu Ser Thr Asn Met Gln Glu Arg Leu Arg Ser Lys Asp Arg Asp Leu 
            180                 185                 190         


Gly Ser Ser 
        195 


<210>  6766
<211>  153
<212>  PRT
<213>  Homo Sapiens

<400>  6766

Met Gly Lys Ile Ser Ser Leu Pro Thr Gln Leu Phe Lys Cys Cys Phe 
1               5                   10                  15      


Cys Asp Phe Leu Lys Val Lys Met His Thr Met Ser Ser Ser His Leu 
            20                  25                  30          


Phe Tyr Leu Ala Leu Cys Leu Leu Thr Phe Thr Ser Ser Ala Thr Ala 
        35                  40                  45              


Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
    50                  55                  60                  


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
65                  70                  75                  80  


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
                85                  90                  95      


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
            100                 105                 110         


Lys Pro Ala Lys Ser Ala Arg Ser Val Arg Ala Gln Arg His Thr Asp 
        115                 120                 125             


Met Pro Lys Thr Gln Lys Glu Val His Leu Lys Asn Ala Ser Arg Gly 
    130                 135                 140                 


Ser Ala Gly Asn Lys Asn Tyr Arg Met 
145                 150             


<210>  6767
<211>  153
<212>  PRT
<213>  Homo Sapiens

<400>  6767

Met Gly Lys Ile Ser Ser Leu Pro Thr Gln Leu Phe Lys Cys Cys Phe 
1               5                   10                  15      


Cys Asp Phe Leu Lys Val Lys Met His Thr Met Ser Ser Ser His Leu 
            20                  25                  30          


Phe Tyr Leu Ala Leu Cys Leu Leu Thr Phe Thr Ser Ser Ala Thr Ala 
        35                  40                  45              


Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
    50                  55                  60                  


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
65                  70                  75                  80  


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
                85                  90                  95      


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
            100                 105                 110         


Lys Pro Ala Lys Ser Ala Arg Ser Val Arg Ala Gln Arg His Thr Asp 
        115                 120                 125             


Met Pro Lys Thr Gln Lys Glu Val His Leu Lys Asn Ala Ser Arg Gly 
    130                 135                 140                 


Ser Ala Gly Asn Lys Asn Tyr Arg Met 
145                 150             


<210>  6768
<211>  158
<212>  PRT
<213>  Homo Sapiens

<400>  6768

Met Gly Lys Ile Ser Ser Leu Pro Thr Gln Leu Phe Lys Cys Cys Phe 
1               5                   10                  15      


Cys Asp Phe Leu Lys Val Lys Met His Thr Met Ser Ser Ser His Leu 
            20                  25                  30          


Phe Tyr Leu Ala Leu Cys Leu Leu Thr Phe Thr Ser Ser Ala Thr Ala 
        35                  40                  45              


Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
    50                  55                  60                  


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
65                  70                  75                  80  


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
                85                  90                  95      


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
            100                 105                 110         


Lys Pro Ala Lys Ser Ala Arg Ser Val Arg Ala Gln Arg His Thr Asp 
        115                 120                 125             


Met Pro Lys Thr Gln Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr 
    130                 135                 140                 


Lys Ser Gln Arg Arg Lys Gly Ser Thr Phe Glu Glu Arg Lys 
145                 150                 155             


<210>  6769
<211>  158
<212>  PRT
<213>  Homo Sapiens

<400>  6769

Met Gly Lys Ile Ser Ser Leu Pro Thr Gln Leu Phe Lys Cys Cys Phe 
1               5                   10                  15      


Cys Asp Phe Leu Lys Val Lys Met His Thr Met Ser Ser Ser His Leu 
            20                  25                  30          


Phe Tyr Leu Ala Leu Cys Leu Leu Thr Phe Thr Ser Ser Ala Thr Ala 
        35                  40                  45              


Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
    50                  55                  60                  


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
65                  70                  75                  80  


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
                85                  90                  95      


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
            100                 105                 110         


Lys Pro Ala Lys Ser Ala Arg Ser Val Arg Ala Gln Arg His Thr Asp 
        115                 120                 125             


Met Pro Lys Thr Gln Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr 
    130                 135                 140                 


Lys Ser Gln Arg Arg Lys Gly Ser Thr Phe Glu Glu Arg Lys 
145                 150                 155             


<210>  6770
<211>  195
<212>  PRT
<213>  Homo Sapiens

<400>  6770

Met Gly Lys Ile Ser Ser Leu Pro Thr Gln Leu Phe Lys Cys Cys Phe 
1               5                   10                  15      


Cys Asp Phe Leu Lys Val Lys Met His Thr Met Ser Ser Ser His Leu 
            20                  25                  30          


Phe Tyr Leu Ala Leu Cys Leu Leu Thr Phe Thr Ser Ser Ala Thr Ala 
        35                  40                  45              


Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
    50                  55                  60                  


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
65                  70                  75                  80  


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
                85                  90                  95      


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
            100                 105                 110         


Lys Pro Ala Lys Ser Ala Arg Ser Val Arg Ala Gln Arg His Thr Asp 
        115                 120                 125             


Met Pro Lys Thr Gln Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr 
    130                 135                 140                 


Lys Ser Gln Arg Arg Lys Gly Trp Pro Lys Thr His Pro Gly Gly Glu 
145                 150                 155                 160 


Gln Lys Glu Gly Thr Glu Ala Ser Leu Gln Ile Arg Gly Lys Lys Lys 
                165                 170                 175     


Glu Gln Arg Arg Glu Ile Gly Ser Arg Asn Ala Glu Cys Arg Gly Lys 
            180                 185                 190         


Lys Gly Lys 
        195 


<210>  6771
<211>  137
<212>  PRT
<213>  Homo Sapiens

<400>  6771

Met Ile Thr Pro Thr Val Lys Met His Thr Met Ser Ser Ser His Leu 
1               5                   10                  15      


Phe Tyr Leu Ala Leu Cys Leu Leu Thr Phe Thr Ser Ser Ala Thr Ala 
            20                  25                  30          


Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
        35                  40                  45              


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
    50                  55                  60                  


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
65                  70                  75                  80  


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
                85                  90                  95      


Lys Pro Ala Lys Ser Ala Arg Ser Val Arg Ala Gln Arg His Thr Asp 
            100                 105                 110         


Met Pro Lys Thr Gln Lys Glu Val His Leu Lys Asn Ala Ser Arg Gly 
        115                 120                 125             


Ser Ala Gly Asn Lys Asn Tyr Arg Met 
    130                 135         


<210>  6772
<211>  183
<212>  PRT
<213>  Homo Sapiens

<400>  6772

Met Gly Ile Pro Met Gly Lys Ser Met Leu Val Leu Leu Thr Phe Leu 
1               5                   10                  15      


Ala Phe Ala Ser Cys Cys Ile Ala Ala Tyr Arg Pro Ser Glu Thr Leu 
            20                  25                  30          


Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg 
        35                  40                  45              


Gly Phe Tyr Phe Arg Leu Pro Gly Arg Pro Ala Ser Arg Val Ser Arg 
    50                  55                  60                  


Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu 
65                  70                  75                  80  


Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Lys Ser Glu Arg Asp 
                85                  90                  95      


Val Ser Thr Pro Pro Thr Val Leu Pro Asp Asn Phe Pro Arg Tyr Pro 
            100                 105                 110         


Val Gly Lys Phe Phe Gln Tyr Asp Thr Trp Lys Gln Ser Thr Gln Arg 
        115                 120                 125             


Leu Arg Arg Gly Leu Pro Ala Leu Leu Arg Ala Arg Arg Gly His Val 
    130                 135                 140                 


Leu Ala Lys Glu Leu Glu Ala Phe Arg Glu Ala Lys Arg His Arg Pro 
145                 150                 155                 160 


Leu Ile Ala Leu Pro Thr Gln Asp Pro Ala His Gly Gly Ala Pro Pro 
                165                 170                 175     


Glu Met Ala Ser Asn Arg Lys 
            180             


<210>  6773
<211>  183
<212>  PRT
<213>  Homo Sapiens

<400>  6773

Met Gly Ile Pro Met Gly Lys Ser Met Leu Val Leu Leu Thr Phe Leu 
1               5                   10                  15      


Ala Phe Ala Ser Cys Cys Ile Ala Ala Tyr Arg Pro Ser Glu Thr Leu 
            20                  25                  30          


Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg 
        35                  40                  45              


Gly Phe Tyr Phe Arg Leu Pro Gly Arg Pro Ala Ser Arg Val Ser Arg 
    50                  55                  60                  


Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu 
65                  70                  75                  80  


Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Lys Ser Glu Arg Asp 
                85                  90                  95      


Val Ser Thr Pro Pro Thr Val Leu Pro Asp Asn Phe Pro Arg Tyr Pro 
            100                 105                 110         


Val Gly Lys Phe Phe Gln Tyr Asp Thr Trp Lys Gln Ser Thr Gln Arg 
        115                 120                 125             


Leu Arg Arg Gly Leu Pro Ala Leu Leu Arg Ala Arg Arg Gly His Val 
    130                 135                 140                 


Leu Ala Lys Glu Leu Glu Ala Phe Arg Glu Ala Lys Arg His Arg Pro 
145                 150                 155                 160 


Leu Ile Ala Leu Pro Thr Gln Asp Pro Ala His Gly Gly Ala Pro Pro 
                165                 170                 175     


Glu Met Ala Ser Asn Arg Lys 
            180             


<210>  6774
<211>  180
<212>  PRT
<213>  Homo Sapiens

<400>  6774

Met Gly Ile Pro Met Gly Lys Ser Met Leu Val Leu Leu Thr Phe Leu 
1               5                   10                  15      


Ala Phe Ala Ser Cys Cys Ile Ala Ala Tyr Arg Pro Ser Glu Thr Leu 
            20                  25                  30          


Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg 
        35                  40                  45              


Gly Phe Tyr Phe Ser Arg Pro Ala Ser Arg Val Ser Arg Arg Ser Arg 
    50                  55                  60                  


Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu 
65                  70                  75                  80  


Glu Thr Tyr Cys Ala Thr Pro Ala Lys Ser Glu Arg Asp Val Ser Thr 
                85                  90                  95      


Pro Pro Thr Val Leu Pro Asp Asn Phe Pro Arg Tyr Pro Val Gly Lys 
            100                 105                 110         


Phe Phe Gln Tyr Asp Thr Trp Lys Gln Ser Thr Gln Arg Leu Arg Arg 
        115                 120                 125             


Gly Leu Pro Ala Leu Leu Arg Ala Arg Arg Gly His Val Leu Ala Lys 
    130                 135                 140                 


Glu Leu Glu Ala Phe Arg Glu Ala Lys Arg His Arg Pro Leu Ile Ala 
145                 150                 155                 160 


Leu Pro Thr Gln Asp Pro Ala His Gly Gly Ala Pro Pro Glu Met Ala 
                165                 170                 175     


Ser Asn Arg Lys 
            180 


<210>  6775
<211>  180
<212>  PRT
<213>  Homo Sapiens

<400>  6775

Met Gly Ile Pro Met Gly Lys Ser Met Leu Val Leu Leu Thr Phe Leu 
1               5                   10                  15      


Ala Phe Ala Ser Cys Cys Ile Ala Ala Tyr Arg Pro Ser Glu Thr Leu 
            20                  25                  30          


Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg 
        35                  40                  45              


Gly Phe Tyr Phe Ser Arg Pro Ala Ser Arg Val Ser Arg Arg Ser Arg 
    50                  55                  60                  


Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu 
65                  70                  75                  80  


Glu Thr Tyr Cys Ala Thr Pro Ala Lys Ser Glu Arg Asp Val Ser Thr 
                85                  90                  95      


Pro Pro Thr Val Leu Pro Asp Asn Phe Pro Arg Tyr Pro Val Gly Lys 
            100                 105                 110         


Phe Phe Gln Tyr Asp Thr Trp Lys Gln Ser Thr Gln Arg Leu Arg Arg 
        115                 120                 125             


Gly Leu Pro Ala Leu Leu Arg Ala Arg Arg Gly His Val Leu Ala Lys 
    130                 135                 140                 


Glu Leu Glu Ala Phe Arg Glu Ala Lys Arg His Arg Pro Leu Ile Ala 
145                 150                 155                 160 


Leu Pro Thr Gln Asp Pro Ala His Gly Gly Ala Pro Pro Glu Met Ala 
                165                 170                 175     


Ser Asn Arg Lys 
            180 


<210>  6776
<211>  180
<212>  PRT
<213>  Homo Sapiens

<400>  6776

Met Gly Ile Pro Met Gly Lys Ser Met Leu Val Leu Leu Thr Phe Leu 
1               5                   10                  15      


Ala Phe Ala Ser Cys Cys Ile Ala Ala Tyr Arg Pro Ser Glu Thr Leu 
            20                  25                  30          


Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg 
        35                  40                  45              


Gly Phe Tyr Phe Ser Arg Pro Ala Ser Arg Val Ser Arg Arg Ser Arg 
    50                  55                  60                  


Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu 
65                  70                  75                  80  


Glu Thr Tyr Cys Ala Thr Pro Ala Lys Ser Glu Arg Asp Val Ser Thr 
                85                  90                  95      


Pro Pro Thr Val Leu Pro Asp Asn Phe Pro Arg Tyr Pro Val Gly Lys 
            100                 105                 110         


Phe Phe Gln Tyr Asp Thr Trp Lys Gln Ser Thr Gln Arg Leu Arg Arg 
        115                 120                 125             


Gly Leu Pro Ala Leu Leu Arg Ala Arg Arg Gly His Val Leu Ala Lys 
    130                 135                 140                 


Glu Leu Glu Ala Phe Arg Glu Ala Lys Arg His Arg Pro Leu Ile Ala 
145                 150                 155                 160 


Leu Pro Thr Gln Asp Pro Ala His Gly Gly Ala Pro Pro Glu Met Ala 
                165                 170                 175     


Ser Asn Arg Lys 
            180 


<210>  6777
<211>  180
<212>  PRT
<213>  Homo Sapiens

<400>  6777

Met Gly Ile Pro Met Gly Lys Ser Met Leu Val Leu Leu Thr Phe Leu 
1               5                   10                  15      


Ala Phe Ala Ser Cys Cys Ile Ala Ala Tyr Arg Pro Ser Glu Thr Leu 
            20                  25                  30          


Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg 
        35                  40                  45              


Gly Phe Tyr Phe Ser Arg Pro Ala Ser Arg Val Ser Arg Arg Ser Arg 
    50                  55                  60                  


Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu 
65                  70                  75                  80  


Glu Thr Tyr Cys Ala Thr Pro Ala Lys Ser Glu Arg Asp Val Ser Thr 
                85                  90                  95      


Pro Pro Thr Val Leu Pro Asp Asn Phe Pro Arg Tyr Pro Val Gly Lys 
            100                 105                 110         


Phe Phe Gln Tyr Asp Thr Trp Lys Gln Ser Thr Gln Arg Leu Arg Arg 
        115                 120                 125             


Gly Leu Pro Ala Leu Leu Arg Ala Arg Arg Gly His Val Leu Ala Lys 
    130                 135                 140                 


Glu Leu Glu Ala Phe Arg Glu Ala Lys Arg His Arg Pro Leu Ile Ala 
145                 150                 155                 160 


Leu Pro Thr Gln Asp Pro Ala His Gly Gly Ala Pro Pro Glu Met Ala 
                165                 170                 175     


Ser Asn Arg Lys 
            180 


<210>  6778
<211>  180
<212>  PRT
<213>  Homo Sapiens

<400>  6778

Met Gly Ile Pro Met Gly Lys Ser Met Leu Val Leu Leu Thr Phe Leu 
1               5                   10                  15      


Ala Phe Ala Ser Cys Cys Ile Ala Ala Tyr Arg Pro Ser Glu Thr Leu 
            20                  25                  30          


Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg 
        35                  40                  45              


Gly Phe Tyr Phe Ser Arg Pro Ala Ser Arg Val Ser Arg Arg Ser Arg 
    50                  55                  60                  


Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu 
65                  70                  75                  80  


Glu Thr Tyr Cys Ala Thr Pro Ala Lys Ser Glu Arg Asp Val Ser Thr 
                85                  90                  95      


Pro Pro Thr Val Leu Pro Asp Asn Phe Pro Arg Tyr Pro Val Gly Lys 
            100                 105                 110         


Phe Phe Gln Tyr Asp Thr Trp Lys Gln Ser Thr Gln Arg Leu Arg Arg 
        115                 120                 125             


Gly Leu Pro Ala Leu Leu Arg Ala Arg Arg Gly His Val Leu Ala Lys 
    130                 135                 140                 


Glu Leu Glu Ala Phe Arg Glu Ala Lys Arg His Arg Pro Leu Ile Ala 
145                 150                 155                 160 


Leu Pro Thr Gln Asp Pro Ala His Gly Gly Ala Pro Pro Glu Met Ala 
                165                 170                 175     


Ser Asn Arg Lys 
            180 


<210>  6779
<211>  236
<212>  PRT
<213>  Homo Sapiens

<400>  6779

Met Val Ser Pro Asp Pro Gln Ile Ile Val Val Ala Pro Glu Thr Glu 
1               5                   10                  15      


Leu Ala Ser Met Gln Val Gln Arg Thr Glu Asp Gly Val Thr Ile Ile 
            20                  25                  30          


Gln Ile Phe Trp Val Gly Arg Lys Gly Glu Leu Leu Arg Arg Thr Pro 
        35                  40                  45              


Val Ser Ser Ala Met Gln Thr Pro Met Gly Ile Pro Met Gly Lys Ser 
    50                  55                  60                  


Met Leu Val Leu Leu Thr Phe Leu Ala Phe Ala Ser Cys Cys Ile Ala 
65                  70                  75                  80  


Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
                85                  90                  95      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            100                 105                 110         


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        115                 120                 125             


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    130                 135                 140                 


Lys Ser Glu Arg Asp Val Ser Thr Pro Pro Thr Val Leu Pro Asp Asn 
145                 150                 155                 160 


Phe Pro Arg Tyr Pro Val Gly Lys Phe Phe Gln Tyr Asp Thr Trp Lys 
                165                 170                 175     


Gln Ser Thr Gln Arg Leu Arg Arg Gly Leu Pro Ala Leu Leu Arg Ala 
            180                 185                 190         


Arg Arg Gly His Val Leu Ala Lys Glu Leu Glu Ala Phe Arg Glu Ala 
        195                 200                 205             


Lys Arg His Arg Pro Leu Ile Ala Leu Pro Thr Gln Asp Pro Ala His 
    210                 215                 220                 


Gly Gly Ala Pro Pro Glu Met Ala Ser Asn Arg Lys 
225                 230                 235     


<210>  6780
<211>  643
<212>  PRT
<213>  Homo Sapiens

<400>  6780

Met Ala Leu Arg Lys Ala Gly Asp Leu Glu Pro Gln Phe Thr Pro Glu 
1               5                   10                  15      


Arg Arg Phe Arg Leu Cys Trp Tyr Gln Ala His Ser Gly Arg Ala Leu 
            20                  25                  30          


Leu Gly Pro Pro Pro Gln Ala Ser Pro Pro Ala Gly Gly Leu Ala Leu 
        35                  40                  45              


Ala Leu Leu Leu Leu Ser Trp Val Ala Leu Gly Pro Arg Ser Leu Glu 
    50                  55                  60                  


Gly Ala Asp Pro Gly Thr Pro Gly Glu Ala Glu Gly Pro Ala Cys Pro 
65                  70                  75                  80  


Ala Ala Cys Val Cys Ser Tyr Asp Asp Asp Ala Asp Glu Leu Ser Val 
                85                  90                  95      


Phe Cys Ser Ser Arg Asn Leu Thr Arg Leu Pro Asp Gly Val Pro Gly 
            100                 105                 110         


Gly Thr Gln Ala Leu Trp Leu Asp Gly Asn Asn Leu Ser Ser Val Pro 
        115                 120                 125             


Pro Ala Ala Phe Gln Asn Leu Ser Ser Leu Gly Phe Leu Asn Leu Gln 
    130                 135                 140                 


Gly Gly Gln Leu Gly Ser Leu Glu Pro Gln Ala Leu Leu Gly Leu Glu 
145                 150                 155                 160 


Asn Leu Cys His Leu His Leu Glu Arg Asn Gln Leu Arg Ser Leu Ala 
                165                 170                 175     


Leu Gly Thr Phe Ala His Thr Pro Ala Leu Ala Ser Leu Gly Leu Ser 
            180                 185                 190         


Asn Asn Arg Leu Ser Arg Leu Glu Asp Gly Leu Phe Glu Gly Leu Gly 
        195                 200                 205             


Ser Leu Trp Asp Leu Asn Leu Gly Trp Asn Ser Leu Ala Val Leu Pro 
    210                 215                 220                 


Asp Ala Ala Phe Arg Gly Leu Gly Ser Leu Arg Glu Leu Val Leu Ala 
225                 230                 235                 240 


Gly Asn Arg Leu Ala Tyr Leu Gln Pro Ala Leu Phe Ser Gly Leu Ala 
                245                 250                 255     


Glu Leu Arg Glu Leu Asp Leu Ser Arg Asn Ala Leu Arg Ala Ile Lys 
            260                 265                 270         


Ala Asn Val Phe Val Gln Leu Pro Arg Leu Gln Lys Leu Tyr Leu Asp 
        275                 280                 285             


Arg Asn Leu Ile Ala Ala Val Ala Pro Gly Ala Phe Leu Gly Leu Lys 
    290                 295                 300                 


Ala Leu Arg Trp Leu Asp Leu Ser His Asn Arg Val Ala Gly Leu Leu 
305                 310                 315                 320 


Glu Asp Thr Phe Pro Gly Leu Leu Gly Leu Arg Val Leu Arg Leu Ser 
                325                 330                 335     


His Asn Ala Ile Ala Ser Leu Arg Pro Arg Thr Phe Lys Asp Leu His 
            340                 345                 350         


Phe Leu Glu Glu Leu Gln Leu Gly His Asn Arg Ile Arg Gln Leu Ala 
        355                 360                 365             


Glu Arg Ser Phe Glu Gly Leu Gly Gln Leu Glu Val Leu Thr Leu Asp 
    370                 375                 380                 


His Asn Gln Leu Gln Glu Val Lys Ala Gly Ala Phe Leu Gly Leu Thr 
385                 390                 395                 400 


Asn Val Ala Val Met Asn Leu Ser Gly Asn Cys Leu Arg Asn Leu Pro 
                405                 410                 415     


Glu Gln Val Phe Arg Gly Leu Gly Lys Leu His Ser Leu His Leu Glu 
            420                 425                 430         


Gly Ser Cys Leu Gly Arg Ile Arg Pro His Thr Phe Thr Gly Leu Ser 
        435                 440                 445             


Gly Leu Arg Arg Leu Phe Leu Lys Asp Asn Gly Leu Val Gly Ile Glu 
    450                 455                 460                 


Glu Gln Ser Leu Trp Gly Leu Ala Glu Leu Leu Glu Leu Asp Leu Thr 
465                 470                 475                 480 


Ser Asn Gln Leu Thr His Leu Pro His Arg Leu Phe Gln Gly Leu Gly 
                485                 490                 495     


Lys Leu Glu Tyr Leu Leu Leu Ser Arg Asn Arg Leu Ala Glu Leu Pro 
            500                 505                 510         


Ala Asp Ala Leu Gly Pro Leu Gln Arg Ala Phe Trp Leu Asp Val Ser 
        515                 520                 525             


His Asn Arg Leu Glu Ala Leu Pro Asn Ser Leu Leu Ala Pro Leu Gly 
    530                 535                 540                 


Arg Leu Arg Tyr Leu Ser Leu Arg Asn Asn Ser Leu Arg Thr Phe Thr 
545                 550                 555                 560 


Pro Gln Pro Pro Gly Leu Glu Arg Leu Trp Leu Glu Gly Asn Pro Trp 
                565                 570                 575     


Asp Cys Gly Cys Pro Leu Lys Ala Leu Arg Asp Phe Ala Leu Gln Asn 
            580                 585                 590         


Pro Ser Ala Val Pro Arg Phe Val Gln Ala Ile Cys Glu Gly Asp Asp 
        595                 600                 605             


Cys Gln Pro Pro Ala Tyr Thr Tyr Asn Asn Ile Thr Cys Ala Ser Pro 
    610                 615                 620                 


Pro Glu Val Val Gly Leu Asp Leu Arg Asp Leu Ser Glu Ala His Phe 
625                 630                 635                 640 


Ala Pro Cys 
            


<210>  6781
<211>  605
<212>  PRT
<213>  Homo Sapiens

<400>  6781

Met Ala Leu Arg Lys Gly Gly Leu Ala Leu Ala Leu Leu Leu Leu Ser 
1               5                   10                  15      


Trp Val Ala Leu Gly Pro Arg Ser Leu Glu Gly Ala Asp Pro Gly Thr 
            20                  25                  30          


Pro Gly Glu Ala Glu Gly Pro Ala Cys Pro Ala Ala Cys Val Cys Ser 
        35                  40                  45              


Tyr Asp Asp Asp Ala Asp Glu Leu Ser Val Phe Cys Ser Ser Arg Asn 
    50                  55                  60                  


Leu Thr Arg Leu Pro Asp Gly Val Pro Gly Gly Thr Gln Ala Leu Trp 
65                  70                  75                  80  


Leu Asp Gly Asn Asn Leu Ser Ser Val Pro Pro Ala Ala Phe Gln Asn 
                85                  90                  95      


Leu Ser Ser Leu Gly Phe Leu Asn Leu Gln Gly Gly Gln Leu Gly Ser 
            100                 105                 110         


Leu Glu Pro Gln Ala Leu Leu Gly Leu Glu Asn Leu Cys His Leu His 
        115                 120                 125             


Leu Glu Arg Asn Gln Leu Arg Ser Leu Ala Leu Gly Thr Phe Ala His 
    130                 135                 140                 


Thr Pro Ala Leu Ala Ser Leu Gly Leu Ser Asn Asn Arg Leu Ser Arg 
145                 150                 155                 160 


Leu Glu Asp Gly Leu Phe Glu Gly Leu Gly Ser Leu Trp Asp Leu Asn 
                165                 170                 175     


Leu Gly Trp Asn Ser Leu Ala Val Leu Pro Asp Ala Ala Phe Arg Gly 
            180                 185                 190         


Leu Gly Ser Leu Arg Glu Leu Val Leu Ala Gly Asn Arg Leu Ala Tyr 
        195                 200                 205             


Leu Gln Pro Ala Leu Phe Ser Gly Leu Ala Glu Leu Arg Glu Leu Asp 
    210                 215                 220                 


Leu Ser Arg Asn Ala Leu Arg Ala Ile Lys Ala Asn Val Phe Val Gln 
225                 230                 235                 240 


Leu Pro Arg Leu Gln Lys Leu Tyr Leu Asp Arg Asn Leu Ile Ala Ala 
                245                 250                 255     


Val Ala Pro Gly Ala Phe Leu Gly Leu Lys Ala Leu Arg Trp Leu Asp 
            260                 265                 270         


Leu Ser His Asn Arg Val Ala Gly Leu Leu Glu Asp Thr Phe Pro Gly 
        275                 280                 285             


Leu Leu Gly Leu Arg Val Leu Arg Leu Ser His Asn Ala Ile Ala Ser 
    290                 295                 300                 


Leu Arg Pro Arg Thr Phe Lys Asp Leu His Phe Leu Glu Glu Leu Gln 
305                 310                 315                 320 


Leu Gly His Asn Arg Ile Arg Gln Leu Ala Glu Arg Ser Phe Glu Gly 
                325                 330                 335     


Leu Gly Gln Leu Glu Val Leu Thr Leu Asp His Asn Gln Leu Gln Glu 
            340                 345                 350         


Val Lys Ala Gly Ala Phe Leu Gly Leu Thr Asn Val Ala Val Met Asn 
        355                 360                 365             


Leu Ser Gly Asn Cys Leu Arg Asn Leu Pro Glu Gln Val Phe Arg Gly 
    370                 375                 380                 


Leu Gly Lys Leu His Ser Leu His Leu Glu Gly Ser Cys Leu Gly Arg 
385                 390                 395                 400 


Ile Arg Pro His Thr Phe Thr Gly Leu Ser Gly Leu Arg Arg Leu Phe 
                405                 410                 415     


Leu Lys Asp Asn Gly Leu Val Gly Ile Glu Glu Gln Ser Leu Trp Gly 
            420                 425                 430         


Leu Ala Glu Leu Leu Glu Leu Asp Leu Thr Ser Asn Gln Leu Thr His 
        435                 440                 445             


Leu Pro His Arg Leu Phe Gln Gly Leu Gly Lys Leu Glu Tyr Leu Leu 
    450                 455                 460                 


Leu Ser Arg Asn Arg Leu Ala Glu Leu Pro Ala Asp Ala Leu Gly Pro 
465                 470                 475                 480 


Leu Gln Arg Ala Phe Trp Leu Asp Val Ser His Asn Arg Leu Glu Ala 
                485                 490                 495     


Leu Pro Asn Ser Leu Leu Ala Pro Leu Gly Arg Leu Arg Tyr Leu Ser 
            500                 505                 510         


Leu Arg Asn Asn Ser Leu Arg Thr Phe Thr Pro Gln Pro Pro Gly Leu 
        515                 520                 525             


Glu Arg Leu Trp Leu Glu Gly Asn Pro Trp Asp Cys Gly Cys Pro Leu 
    530                 535                 540                 


Lys Ala Leu Arg Asp Phe Ala Leu Gln Asn Pro Ser Ala Val Pro Arg 
545                 550                 555                 560 


Phe Val Gln Ala Ile Cys Glu Gly Asp Asp Cys Gln Pro Pro Ala Tyr 
                565                 570                 575     


Thr Tyr Asn Asn Ile Thr Cys Ala Ser Pro Pro Glu Val Val Gly Leu 
            580                 585                 590         


Asp Leu Arg Asp Leu Ser Glu Ala His Phe Ala Pro Cys 
        595                 600                 605 


<210>  6782
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  6782

Met Thr Val Gly Arg Arg Leu Pro Thr Ala Leu His Gly Ala Cys Gln 
1               5                   10                  15      


Glu Ala Trp Pro Trp Arg Cys Cys Cys Cys Pro Gly Trp His Trp Ala 
            20                  25                  30          


Pro Ala Ala Trp Arg Glu Gln Thr Pro Glu Arg Arg Gly Lys Pro Arg 
        35                  40                  45              


Ala Gln Arg Ala Arg Pro Pro Val Ser Ala Ala Thr Met Thr Thr Arg 
    50                  55                  60                  


Met Ser Ser Ala Ser Ser Ala Ala Pro Gly Thr Ser Arg Ala Cys Leu 
65                  70                  75                  80  


Met Glu Ser Arg Ala Ala Pro Lys Pro Cys Gly Trp Thr Ala Thr Thr 
                85                  90                  95      


Ser Arg Pro Ser Pro Arg Gln Pro Ser Arg Thr Ser Pro Ala Trp Ala 
            100                 105                 110         


Ser Ser Thr Cys Arg Ala Ala Ser Trp Ala Ala Trp Ser His Arg Arg 
        115                 120                 125             


Cys Trp Ala 
    130     


<210>  6783
<211>  216
<212>  PRT
<213>  Homo Sapiens

<400>  6783

Met Ser Glu Val Pro Val Ala Arg Val Trp Leu Val Leu Leu Leu Leu 
1               5                   10                  15      


Thr Val Gln Val Gly Val Thr Ala Gly Ala Pro Trp Gln Cys Ala Pro 
            20                  25                  30          


Cys Ser Ala Glu Lys Leu Ala Leu Cys Pro Pro Val Ser Ala Ser Cys 
        35                  40                  45              


Ser Glu Val Thr Arg Ser Ala Gly Cys Gly Cys Cys Pro Met Cys Ala 
    50                  55                  60                  


Leu Pro Leu Gly Ala Ala Cys Gly Val Ala Thr Ala Arg Cys Ala Arg 
65                  70                  75                  80  


Gly Leu Ser Cys Arg Ala Leu Pro Gly Glu Gln Gln Pro Leu His Ala 
                85                  90                  95      


Leu Thr Arg Gly Gln Gly Ala Cys Val Gln Glu Ser Asp Ala Ser Ala 
            100                 105                 110         


Pro His Ala Ala Glu Ala Gly Ser Pro Glu Ser Pro Glu Ser Thr Glu 
        115                 120                 125             


Ile Thr Glu Glu Glu Leu Leu Asp Asn Phe His Leu Met Ala Pro Ser 
    130                 135                 140                 


Glu Glu Asp His Ser Ile Leu Trp Asp Ala Ile Ser Thr Tyr Asp Gly 
145                 150                 155                 160 


Ser Lys Ala Leu His Val Thr Asn Ile Lys Lys Trp Lys Cys Glu Thr 
                165                 170                 175     


Ser Met Asp Gly Glu Ala Gly Leu Cys Trp Cys Val Tyr Pro Trp Asn 
            180                 185                 190         


Gly Lys Arg Ile Pro Gly Ser Pro Glu Ile Arg Gly Asp Pro Asn Cys 
        195                 200                 205             


Gln Ile Tyr Phe Asn Val Gln Asn 
    210                 215     


<210>  6784
<211>  259
<212>  PRT
<213>  Homo Sapiens

<400>  6784

Met Ser Glu Val Pro Val Ala Arg Val Trp Leu Val Leu Leu Leu Leu 
1               5                   10                  15      


Thr Val Gln Val Gly Val Thr Ala Gly Ala Pro Trp Gln Cys Ala Pro 
            20                  25                  30          


Cys Ser Ala Glu Lys Leu Ala Leu Cys Pro Pro Val Ser Ala Ser Cys 
        35                  40                  45              


Ser Glu Val Thr Arg Ser Ala Gly Cys Gly Cys Cys Pro Met Cys Ala 
    50                  55                  60                  


Leu Pro Leu Gly Ala Ala Cys Gly Val Ala Thr Ala Arg Cys Ala Arg 
65                  70                  75                  80  


Gly Leu Ser Cys Arg Ala Leu Pro Gly Glu Gln Gln Pro Leu His Ala 
                85                  90                  95      


Leu Thr Arg Gly Gln Gly Ala Cys Val Gln Glu Ser Asp Ala Ser Ala 
            100                 105                 110         


Pro His Ala Ala Glu Ala Gly Ser Pro Glu Ser Pro Glu Ser Thr Glu 
        115                 120                 125             


Ile Thr Glu Glu Glu Leu Leu Asp Asn Phe His Leu Met Ala Pro Ser 
    130                 135                 140                 


Glu Glu Asp His Ser Ile Leu Trp Asp Ala Ile Ser Thr Tyr Asp Gly 
145                 150                 155                 160 


Ser Lys Ala Leu His Val Thr Asn Ile Lys Lys Trp Lys Glu Pro Cys 
                165                 170                 175     


Arg Ile Glu Leu Tyr Arg Val Val Glu Ser Leu Ala Lys Ala Gln Glu 
            180                 185                 190         


Thr Ser Gly Glu Glu Ile Ser Lys Phe Tyr Leu Pro Asn Cys Asn Lys 
        195                 200                 205             


Asn Gly Phe Tyr His Ser Arg Gln Cys Glu Thr Ser Met Asp Gly Glu 
    210                 215                 220                 


Ala Gly Leu Cys Trp Cys Val Tyr Pro Trp Asn Gly Lys Arg Ile Pro 
225                 230                 235                 240 


Gly Ser Pro Glu Ile Arg Gly Asp Pro Asn Cys Gln Ile Tyr Phe Asn 
                245                 250                 255     


Val Gln Asn 
            


<210>  6785
<211>  257
<212>  PRT
<213>  Homo Sapiens

<400>  6785

Met Ser Glu Val Pro Val Ala Arg Val Trp Leu Val Leu Leu Leu Leu 
1               5                   10                  15      


Thr Val Gln Val Gly Val Thr Ala Gly Ala Pro Trp Gln Cys Ala Pro 
            20                  25                  30          


Cys Ser Ala Glu Lys Leu Ala Leu Cys Pro Pro Val Ser Ala Ser Cys 
        35                  40                  45              


Ser Glu Val Thr Arg Ser Ala Gly Cys Gly Cys Cys Pro Met Cys Ala 
    50                  55                  60                  


Leu Pro Leu Gly Ala Ala Cys Gly Val Ala Thr Ala Arg Cys Ala Arg 
65                  70                  75                  80  


Gly Leu Ser Cys Arg Ala Leu Pro Gly Glu Gln Gln Pro Leu His Ala 
                85                  90                  95      


Leu Thr Arg Gly Gln Gly Ala Cys Val Gln Glu Ser Asp Ala Ser Ala 
            100                 105                 110         


Pro His Ala Ala Glu Ala Gly Ser Pro Glu Ser Pro Glu Ser Thr Glu 
        115                 120                 125             


Ile Thr Glu Glu Glu Leu Leu Asp Asn Phe His Leu Met Ala Pro Ser 
    130                 135                 140                 


Glu Glu Asp His Ser Ile Leu Trp Asp Ala Ile Ser Thr Tyr Asp Gly 
145                 150                 155                 160 


Ser Lys Ala Leu His Val Thr Asn Ile Lys Lys Trp Lys Glu Pro Cys 
                165                 170                 175     


Arg Ile Glu Leu Tyr Arg Val Val Glu Ser Leu Ala Lys Ala Gln Glu 
            180                 185                 190         


Thr Ser Gly Glu Glu Ile Ser Lys Phe Tyr Leu Pro Asn Cys Asn Lys 
        195                 200                 205             


Asn Gly Phe Tyr His Ser Arg Gln Thr Ser Met Asp Gly Glu Ala Gly 
    210                 215                 220                 


Leu Cys Trp Cys Val Tyr Pro Trp Asn Gly Lys Arg Ile Pro Gly Ser 
225                 230                 235                 240 


Pro Glu Ile Arg Gly Asp Pro Asn Cys Gln Ile Tyr Phe Asn Val Gln 
                245                 250                 255     


Asn 
    


<210>  6786
<211>  98
<212>  PRT
<213>  Homo Sapiens

<400>  6786

Lys His His Leu Gly Leu Glu Glu Pro Lys Lys Leu Arg Pro Pro Pro 
1               5                   10                  15      


Ala Arg Gln Leu Leu Ala Glu Leu Ala Ser Gly Ala Cys Phe Val Gly 
            20                  25                  30          


Leu Leu Ser Ser Leu Arg Ala Ser Pro Ala Val Cys Ala Cys Arg Leu 
        35                  40                  45              


Pro Ala Asn Arg Asn Trp Thr Arg Ser Trp Ser Gly Ser Pro Pro Cys 
    50                  55                  60                  


Ala Phe Arg Met Ser Gly Ala Leu Trp Ser Thr Ser Thr Pro Cys Thr 
65                  70                  75                  80  


Ser Pro Thr Val Thr Ser Met Ala Cys Thr Thr Ser Asn Ser Ala Arg 
                85                  90                  95      


Cys Leu 
        


<210>  6787
<211>  325
<212>  PRT
<213>  Homo Sapiens

<400>  6787

Met Leu Pro Arg Val Gly Cys Pro Ala Leu Pro Leu Pro Pro Pro Pro 
1               5                   10                  15      


Leu Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Ser Gly Gly Gly Gly 
            20                  25                  30          


Gly Ala Arg Ala Glu Val Leu Phe Arg Cys Pro Pro Cys Thr Pro Glu 
        35                  40                  45              


Arg Leu Ala Ala Cys Gly Pro Pro Pro Val Ala Pro Pro Ala Ala Val 
    50                  55                  60                  


Ala Ala Val Ala Gly Gly Ala Arg Met Pro Cys Ala Glu Leu Val Arg 
65                  70                  75                  80  


Glu Pro Gly Cys Gly Cys Cys Ser Val Cys Ala Arg Leu Glu Gly Glu 
                85                  90                  95      


Ala Cys Gly Val Tyr Thr Pro Arg Cys Gly Gln Gly Leu Arg Cys Tyr 
            100                 105                 110         


Pro His Pro Gly Ser Glu Leu Pro Leu Gln Ala Leu Val Met Gly Glu 
        115                 120                 125             


Gly Thr Cys Glu Lys Arg Arg Asp Ala Glu Tyr Gly Ala Ser Pro Glu 
    130                 135                 140                 


Gln Val Ala Asp Asn Gly Asp Asp His Ser Glu Gly Gly Leu Val Glu 
145                 150                 155                 160 


Asn His Val Asp Ser Thr Met Asn Met Leu Gly Gly Gly Gly Ser Ala 
                165                 170                 175     


Gly Arg Lys Pro Leu Lys Ser Gly Met Lys Glu Leu Ala Val Phe Arg 
            180                 185                 190         


Glu Lys Val Thr Glu Gln His Arg Gln Met Gly Lys Gly Gly Lys His 
        195                 200                 205             


His Leu Gly Leu Glu Glu Pro Lys Lys Leu Arg Pro Pro Pro Ala Arg 
    210                 215                 220                 


Thr Pro Cys Gln Gln Glu Leu Asp Gln Val Leu Glu Arg Ile Ser Thr 
225                 230                 235                 240 


Met Arg Leu Pro Asp Glu Arg Gly Pro Leu Glu His Leu Tyr Ser Leu 
                245                 250                 255     


His Ile Pro Asn Cys Asp Lys His Gly Leu Tyr Asn Leu Lys Gln Cys 
            260                 265                 270         


Lys Met Ser Leu Asn Gly Gln Arg Gly Glu Cys Trp Cys Val Asn Pro 
        275                 280                 285             


Asn Thr Gly Lys Leu Ile Gln Gly Ala Pro Thr Ile Arg Gly Asp Pro 
    290                 295                 300                 


Glu Cys His Leu Phe Tyr Asn Glu Gln Gln Glu Ala Arg Gly Val His 
305                 310                 315                 320 


Thr Gln Arg Met Gln 
                325 


<210>  6788
<211>  78
<212>  PRT
<213>  Homo Sapiens

<400>  6788

Met Asn Met Leu Gly Gly Gly Gly Ser Ala Gly Arg Lys Pro Leu Lys 
1               5                   10                  15      


Ser Gly Met Lys Glu Leu Ala Val Phe Arg Glu Lys Val Thr Glu Gln 
            20                  25                  30          


His Arg Gln Met Gly Lys Gly Gly Lys His His Leu Gly Leu Glu Glu 
        35                  40                  45              


Pro Lys Lys Leu Arg Pro Pro Pro Ala Arg Thr Pro Cys Gln Gln Glu 
    50                  55                  60                  


Leu Asp Gln Val Leu Glu Arg Ile Ser Thr Met Arg Leu Pro 
65                  70                  75              


<210>  6789
<211>  181
<212>  PRT
<213>  Homo Sapiens

<400>  6789

Met Pro Cys Asn Asn Gly Asp Asp His Ser Glu Gly Gly Leu Val Glu 
1               5                   10                  15      


Asn His Val Asp Ser Thr Met Asn Met Leu Gly Gly Gly Gly Ser Ala 
            20                  25                  30          


Gly Arg Lys Pro Leu Lys Ser Gly Met Lys Glu Leu Ala Val Phe Arg 
        35                  40                  45              


Glu Lys Val Thr Glu Gln His Arg Gln Met Gly Lys Gly Gly Lys His 
    50                  55                  60                  


His Leu Gly Leu Glu Glu Pro Lys Lys Leu Arg Pro Pro Pro Ala Arg 
65                  70                  75                  80  


Thr Pro Cys Gln Gln Glu Leu Asp Gln Val Leu Glu Arg Ile Ser Thr 
                85                  90                  95      


Met Arg Leu Pro Asp Glu Arg Gly Pro Leu Glu His Leu Tyr Ser Leu 
            100                 105                 110         


His Ile Pro Asn Cys Asp Lys His Gly Leu Tyr Asn Leu Lys Gln Cys 
        115                 120                 125             


Lys Met Ser Leu Asn Gly Gln Arg Gly Glu Cys Trp Cys Val Asn Pro 
    130                 135                 140                 


Asn Thr Gly Lys Leu Ile Gln Gly Ala Pro Thr Ile Arg Gly Asp Pro 
145                 150                 155                 160 


Glu Cys His Leu Phe Tyr Asn Glu Gln Gln Glu Ala Arg Gly Val His 
                165                 170                 175     


Thr Gln Arg Met Gln 
            180     


<210>  6790
<211>  194
<212>  PRT
<213>  Homo Sapiens

<400>  6790

Met Gln Arg Ala Arg Pro Leu Gln Ala Leu Leu Asp Gly Arg Gly Leu 
1               5                   10                  15      


Cys Val Asn Ala Ser Ala Val Ser Arg Leu Arg Ala Tyr Leu Leu Pro 
            20                  25                  30          


Ala Pro Pro Ala Pro Gly Asn Ala Ser Glu Ser Glu Glu Asp Arg Ser 
        35                  40                  45              


Ala Gly Ser Val Glu Ser Pro Ser Val Ser Ser Thr His Arg Val Ser 
    50                  55                  60                  


Asp Pro Lys Phe His Pro Leu His Ser Lys Ile Ile Ile Ile Lys Lys 
65                  70                  75                  80  


Gly His Ala Lys Asp Ser Gln Arg Tyr Lys Val Asp Tyr Glu Ser Gln 
                85                  90                  95      


Ser Thr Asp Thr Gln Asn Phe Ser Ser Glu Ser Lys Arg Glu Thr Glu 
            100                 105                 110         


Tyr Gly Pro Cys Arg Arg Glu Met Glu Asp Thr Leu Asn His Leu Lys 
        115                 120                 125             


Phe Leu Asn Val Leu Ser Pro Arg Gly Val His Ile Pro Asn Cys Asp 
    130                 135                 140                 


Lys Lys Gly Phe Tyr Lys Lys Lys Gln Cys Arg Pro Ser Lys Gly Arg 
145                 150                 155                 160 


Lys Arg Gly Phe Cys Trp Cys Val Asp Lys Tyr Gly Gln Pro Leu Pro 
                165                 170                 175     


Gly Tyr Thr Thr Lys Gly Lys Glu Asp Val His Cys Tyr Ser Met Gln 
            180                 185                 190         


Ser Lys 
        


<210>  6791
<211>  297
<212>  PRT
<213>  Homo Sapiens

<400>  6791

Met Gln Arg Ala Arg Pro Thr Leu Trp Ala Ala Ala Leu Thr Leu Leu 
1               5                   10                  15      


Val Leu Leu Arg Gly Pro Pro Val Ala Arg Ala Gly Ala Ser Ser Ala 
            20                  25                  30          


Gly Leu Gly Pro Val Val Arg Cys Glu Pro Cys Asp Ala Arg Ala Leu 
        35                  40                  45              


Ala Gln Cys Ala Pro Pro Pro Ala Val Cys Ala Glu Leu Val Arg Glu 
    50                  55                  60                  


Pro Gly Cys Gly Cys Cys Leu Thr Cys Ala Leu Ser Glu Gly Gln Pro 
65                  70                  75                  80  


Cys Gly Ile Tyr Thr Glu Arg Cys Gly Ser Gly Leu Arg Cys Gln Pro 
                85                  90                  95      


Ser Pro Asp Glu Ala Arg Pro Leu Gln Ala Leu Leu Asp Gly Arg Gly 
            100                 105                 110         


Leu Cys Val Asn Ala Ser Ala Val Ser Arg Leu Arg Ala Tyr Leu Leu 
        115                 120                 125             


Pro Ala Pro Pro Ala Pro Gly Glu Pro Pro Ala Pro Gly Asn Ala Ser 
    130                 135                 140                 


Glu Ser Glu Glu Asp Arg Ser Ala Gly Ser Val Glu Ser Pro Ser Val 
145                 150                 155                 160 


Ser Ser Thr His Arg Val Ser Asp Pro Lys Phe His Pro Leu His Ser 
                165                 170                 175     


Lys Ile Ile Ile Ile Lys Lys Gly His Ala Lys Asp Ser Gln Arg Tyr 
            180                 185                 190         


Lys Val Asp Tyr Glu Ser Gln Ser Thr Asp Thr Gln Asn Phe Ser Ser 
        195                 200                 205             


Glu Ser Lys Arg Glu Thr Glu Tyr Gly Pro Cys Arg Arg Glu Met Glu 
    210                 215                 220                 


Asp Thr Leu Asn His Leu Lys Phe Leu Asn Val Leu Ser Pro Arg Gly 
225                 230                 235                 240 


Val His Ile Pro Asn Cys Asp Lys Lys Gly Phe Tyr Lys Lys Lys Gln 
                245                 250                 255     


Cys Arg Pro Ser Lys Gly Arg Lys Arg Gly Phe Cys Trp Cys Val Asp 
            260                 265                 270         


Lys Tyr Gly Gln Pro Leu Pro Gly Tyr Thr Thr Lys Gly Lys Glu Asp 
        275                 280                 285             


Val His Cys Tyr Ser Met Gln Ser Lys 
    290                 295         


<210>  6792
<211>  291
<212>  PRT
<213>  Homo Sapiens

<400>  6792

Met Gln Arg Ala Arg Pro Thr Leu Trp Ala Ala Ala Leu Thr Leu Leu 
1               5                   10                  15      


Val Leu Leu Arg Gly Pro Pro Val Ala Arg Ala Gly Ala Ser Ser Ala 
            20                  25                  30          


Gly Leu Gly Pro Val Val Arg Cys Glu Pro Cys Asp Ala Arg Ala Leu 
        35                  40                  45              


Ala Gln Cys Ala Pro Pro Pro Ala Val Cys Ala Glu Leu Val Arg Glu 
    50                  55                  60                  


Pro Gly Cys Gly Cys Cys Leu Thr Cys Ala Leu Ser Glu Gly Gln Pro 
65                  70                  75                  80  


Cys Gly Ile Tyr Thr Glu Arg Cys Gly Ser Gly Leu Arg Cys Gln Pro 
                85                  90                  95      


Ser Pro Asp Glu Ala Arg Pro Leu Gln Ala Leu Leu Asp Gly Arg Gly 
            100                 105                 110         


Leu Cys Val Asn Ala Ser Ala Val Ser Arg Leu Arg Ala Tyr Leu Leu 
        115                 120                 125             


Pro Ala Pro Pro Ala Pro Gly Asn Ala Ser Glu Ser Glu Glu Asp Arg 
    130                 135                 140                 


Ser Ala Gly Ser Val Glu Ser Pro Ser Val Ser Ser Thr His Arg Val 
145                 150                 155                 160 


Ser Asp Pro Lys Phe His Pro Leu His Ser Lys Ile Ile Ile Ile Lys 
                165                 170                 175     


Lys Gly His Ala Lys Asp Ser Gln Arg Tyr Lys Val Asp Tyr Glu Ser 
            180                 185                 190         


Gln Ser Thr Asp Thr Gln Asn Phe Ser Ser Glu Ser Lys Arg Glu Thr 
        195                 200                 205             


Glu Tyr Gly Pro Cys Arg Arg Glu Met Glu Asp Thr Leu Asn His Leu 
    210                 215                 220                 


Lys Phe Leu Asn Val Leu Ser Pro Arg Gly Val His Ile Pro Asn Cys 
225                 230                 235                 240 


Asp Lys Lys Gly Phe Tyr Lys Lys Lys Gln Cys Arg Pro Ser Lys Gly 
                245                 250                 255     


Arg Lys Arg Gly Phe Cys Trp Cys Val Asp Lys Tyr Gly Gln Pro Leu 
            260                 265                 270         


Pro Gly Tyr Thr Thr Lys Gly Lys Glu Asp Val His Cys Tyr Ser Met 
        275                 280                 285             


Gln Ser Lys 
    290     


<210>  6793
<211>  270
<212>  PRT
<213>  Homo Sapiens

<400>  6793

Met Gln Arg Ala Arg Pro Thr Leu Trp Ala Ala Ala Leu Thr Leu Leu 
1               5                   10                  15      


Val Arg Cys Glu Pro Cys Asp Ala Arg Ala Leu Ala Gln Cys Ala Pro 
            20                  25                  30          


Pro Pro Ala Val Cys Ala Glu Leu Val Arg Glu Pro Gly Cys Gly Cys 
        35                  40                  45              


Cys Leu Thr Cys Ala Leu Ser Glu Gly Gln Pro Cys Gly Ile Tyr Thr 
    50                  55                  60                  


Glu Arg Cys Gly Ser Gly Leu Arg Cys Gln Pro Ser Pro Asp Glu Ala 
65                  70                  75                  80  


Arg Pro Leu Gln Ala Leu Leu Asp Gly Arg Gly Leu Cys Val Asn Ala 
                85                  90                  95      


Ser Ala Val Ser Arg Leu Arg Ala Tyr Leu Leu Pro Ala Pro Pro Ala 
            100                 105                 110         


Pro Gly Asn Ala Ser Glu Ser Glu Glu Asp Arg Ser Ala Gly Ser Val 
        115                 120                 125             


Glu Ser Pro Ser Val Ser Ser Thr His Arg Val Ser Asp Pro Lys Phe 
    130                 135                 140                 


His Pro Leu His Ser Lys Ile Ile Ile Ile Lys Lys Gly His Ala Lys 
145                 150                 155                 160 


Asp Ser Gln Arg Tyr Lys Val Asp Tyr Glu Ser Gln Ser Thr Asp Thr 
                165                 170                 175     


Gln Asn Phe Ser Ser Glu Ser Lys Arg Glu Thr Glu Tyr Gly Pro Cys 
            180                 185                 190         


Arg Arg Glu Met Glu Asp Thr Leu Asn His Leu Lys Phe Leu Asn Val 
        195                 200                 205             


Leu Ser Pro Arg Gly Val His Ile Pro Asn Cys Asp Lys Lys Gly Phe 
    210                 215                 220                 


Tyr Lys Lys Lys Gln Cys Arg Pro Ser Lys Gly Arg Lys Arg Gly Phe 
225                 230                 235                 240 


Cys Trp Cys Val Asp Lys Tyr Gly Gln Pro Leu Pro Gly Tyr Thr Thr 
                245                 250                 255     


Lys Gly Lys Glu Asp Val His Cys Tyr Ser Met Gln Ser Lys 
            260                 265                 270 


<210>  6794
<211>  263
<212>  PRT
<213>  Homo Sapiens

<400>  6794

Met Gln Arg Ala Arg Pro Thr Leu Trp Ala Ala Cys Glu Pro Cys Asp 
1               5                   10                  15      


Ala Arg Ala Leu Ala Gln Cys Ala Pro Pro Pro Ala Val Cys Ala Glu 
            20                  25                  30          


Leu Val Arg Glu Pro Gly Cys Gly Cys Cys Leu Thr Cys Ala Leu Ser 
        35                  40                  45              


Glu Gly Gln Pro Cys Gly Ile Tyr Thr Glu Arg Cys Gly Ser Gly Leu 
    50                  55                  60                  


Arg Cys Gln Pro Ser Pro Asp Glu Ala Arg Pro Leu Gln Ala Leu Leu 
65                  70                  75                  80  


Asp Gly Arg Gly Leu Cys Val Asn Ala Ser Ala Val Ser Arg Leu Arg 
                85                  90                  95      


Ala Tyr Leu Leu Pro Ala Pro Pro Ala Pro Gly Asn Ala Ser Glu Ser 
            100                 105                 110         


Glu Glu Asp Arg Ser Ala Gly Ser Val Glu Ser Pro Ser Val Ser Ser 
        115                 120                 125             


Thr His Arg Val Ser Asp Pro Lys Phe His Pro Leu His Ser Lys Ile 
    130                 135                 140                 


Ile Ile Ile Lys Lys Gly His Ala Lys Asp Ser Gln Arg Tyr Lys Val 
145                 150                 155                 160 


Asp Tyr Glu Ser Gln Ser Thr Asp Thr Gln Asn Phe Ser Ser Glu Ser 
                165                 170                 175     


Lys Arg Glu Thr Glu Tyr Gly Pro Cys Arg Arg Glu Met Glu Asp Thr 
            180                 185                 190         


Leu Asn His Leu Lys Phe Leu Asn Val Leu Ser Pro Arg Gly Val His 
        195                 200                 205             


Ile Pro Asn Cys Asp Lys Lys Gly Phe Tyr Lys Lys Lys Gln Cys Arg 
    210                 215                 220                 


Pro Ser Lys Gly Arg Lys Arg Gly Phe Cys Trp Cys Val Asp Lys Tyr 
225                 230                 235                 240 


Gly Gln Pro Leu Pro Gly Tyr Thr Thr Lys Gly Lys Glu Asp Val His 
                245                 250                 255     


Cys Tyr Ser Met Gln Ser Lys 
            260             


<210>  6795
<211>  132
<212>  PRT
<213>  Homo Sapiens

<400>  6795

Met Arg Ser Ala Val Cys Gln Phe Pro Arg His Arg Leu Ala Ala Gly 
1               5                   10                  15      


Arg Pro His Pro Glu Ser Gly Arg Gly Asn Ala Ser Glu Ser Glu Glu 
            20                  25                  30          


Asp Arg Ser Ala Gly Ser Val Glu Ser Pro Ser Val Ser Ser Thr His 
        35                  40                  45              


Arg Val Ser Asp Pro Lys Phe His Pro Leu His Ser Lys Ile Ile Ile 
    50                  55                  60                  


Ile Lys Lys Gly His Ala Lys Asp Ser Gln Arg Tyr Lys Val Asp Tyr 
65                  70                  75                  80  


Glu Ser Gln Ser Thr Asp Thr Gln Asn Phe Ser Ser Glu Ser Lys Arg 
                85                  90                  95      


Glu Thr Glu Tyr Gly Pro Cys Arg Arg Glu Met Glu Asp Thr Leu Asn 
            100                 105                 110         


His Leu Lys Phe Leu Asn Val Leu Ser Pro Arg Gly Val His Ile Pro 
        115                 120                 125             


Asn Cys Asp Lys 
    130         


<210>  6796
<211>  143
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6796

Xaa Glu Ser Pro Ser Val Ser Ser Thr His Arg Val Ser Asp Pro Lys 
1               5                   10                  15      


Phe His Pro Leu His Ser Lys Ile Ile Ile Ile Lys Lys Gly His Ala 
            20                  25                  30          


Lys Asp Ser Gln Arg Tyr Lys Val Asp Tyr Glu Ser Gln Ser Thr Asp 
        35                  40                  45              


Thr Gln Asn Phe Ser Ser Glu Ser Lys Arg Glu Thr Glu Tyr Gly Pro 
    50                  55                  60                  


Cys Arg Arg Glu Met Glu Asp Thr Leu Asn His Leu Lys Phe Leu Asn 
65                  70                  75                  80  


Val Leu Ser Pro Arg Gly Val His Ile Pro Asn Cys Asp Lys Lys Gly 
                85                  90                  95      


Phe Tyr Lys Lys Lys Gln Cys Arg Pro Ser Lys Gly Arg Lys Arg Gly 
            100                 105                 110         


Phe Cys Trp Cys Val Asp Lys Tyr Gly Gln Pro Leu Pro Gly Tyr Thr 
        115                 120                 125             


Thr Lys Gly Lys Glu Asp Val His Cys Tyr Ser Met Gln Ser Lys 
    130                 135                 140             


<210>  6797
<211>  153
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6797

Xaa Ser Glu Glu Asp Arg Ser Ala Gly Ser Val Glu Ser Pro Ser Val 
1               5                   10                  15      


Ser Ser Thr His Arg Val Ser Asp Pro Lys Phe His Pro Leu His Ser 
            20                  25                  30          


Lys Ile Ile Ile Ile Lys Lys Gly His Ala Lys Asp Ser Gln Arg Tyr 
        35                  40                  45              


Lys Val Asp Tyr Glu Ser Gln Ser Thr Asp Thr Gln Asn Phe Ser Ser 
    50                  55                  60                  


Glu Ser Lys Arg Glu Thr Glu Tyr Gly Pro Cys Arg Arg Glu Met Glu 
65                  70                  75                  80  


Asp Thr Leu Asn His Leu Lys Phe Leu Asn Val Leu Ser Pro Arg Gly 
                85                  90                  95      


Val His Ile Pro Asn Cys Asp Lys Lys Gly Phe Tyr Lys Lys Lys Gln 
            100                 105                 110         


Cys Arg Pro Ser Lys Gly Arg Lys Arg Gly Phe Cys Trp Cys Val Asp 
        115                 120                 125             


Lys Tyr Gly Gln Pro Leu Pro Gly Tyr Thr Thr Lys Gly Lys Glu Asp 
    130                 135                 140                 


Val His Cys Tyr Ser Met Gln Ser Lys 
145                 150             


<210>  6798
<211>  258
<212>  PRT
<213>  Homo Sapiens

<400>  6798

Met Leu Pro Leu Cys Leu Val Ala Ala Leu Leu Leu Ala Ala Gly Pro 
1               5                   10                  15      


Gly Pro Ser Leu Gly Asp Glu Ala Ile His Cys Pro Pro Cys Ser Glu 
            20                  25                  30          


Glu Lys Leu Ala Arg Cys Arg Pro Pro Val Gly Cys Glu Glu Leu Val 
        35                  40                  45              


Arg Glu Pro Gly Cys Gly Cys Cys Ala Thr Cys Ala Leu Gly Leu Gly 
    50                  55                  60                  


Met Pro Cys Gly Val Tyr Thr Pro Arg Cys Gly Ser Gly Leu Arg Cys 
65                  70                  75                  80  


Tyr Pro Pro Arg Gly Val Glu Lys Pro Leu His Thr Leu Met His Gly 
                85                  90                  95      


Gln Gly Val Cys Met Glu Leu Ala Glu Ile Glu Ala Ile Gln Glu Ser 
            100                 105                 110         


Leu Gln Pro Ser Asp Lys Asp Glu Gly Asp His Pro Asn Asn Ser Phe 
        115                 120                 125             


Ser Pro Cys Ser Ala His Asp Arg Arg Cys Leu Gln Lys His Phe Ala 
    130                 135                 140                 


Lys Ile Arg Asp Arg Ser Thr Ser Gly Gly Lys Met Lys Val Asn Gly 
145                 150                 155                 160 


Ala Pro Arg Glu Asp Ala Arg Pro Val Pro Gln Gly Ser Cys Gln Ser 
                165                 170                 175     


Glu Leu His Arg Ala Leu Glu Arg Leu Ala Ala Ser Gln Ser Arg Thr 
            180                 185                 190         


His Glu Asp Leu Tyr Ile Ile Pro Ile Pro Asn Cys Asp Arg Asn Gly 
        195                 200                 205             


Asn Phe His Pro Lys Gln Cys His Pro Ala Leu Asp Gly Gln Arg Gly 
    210                 215                 220                 


Lys Cys Trp Cys Val Asp Arg Lys Thr Gly Val Lys Leu Pro Gly Gly 
225                 230                 235                 240 


Leu Glu Pro Lys Gly Glu Leu Asp Cys His Gln Leu Ala Asp Ser Phe 
                245                 250                 255     


Arg Glu 
        


<210>  6799
<211>  272
<212>  PRT
<213>  Homo Sapiens

<400>  6799

Met Val Leu Leu Thr Ala Val Leu Leu Leu Leu Ala Ala Tyr Ala Gly 
1               5                   10                  15      


Pro Ala Gln Ser Leu Gly Ser Phe Val His Cys Glu Pro Cys Asp Glu 
            20                  25                  30          


Lys Ala Leu Ser Met Cys Pro Pro Ser Pro Leu Gly Cys Glu Leu Val 
        35                  40                  45              


Lys Glu Pro Gly Cys Gly Cys Cys Met Thr Cys Ala Leu Ala Glu Gly 
    50                  55                  60                  


Gln Ser Cys Gly Val Tyr Thr Glu Arg Cys Ala Gln Gly Leu Arg Cys 
65                  70                  75                  80  


Leu Pro Arg Gln Asp Glu Glu Lys Pro Leu His Ala Leu Leu His Gly 
                85                  90                  95      


Arg Gly Val Cys Leu Asn Glu Lys Ser Tyr Arg Glu Gln Val Lys Ile 
            100                 105                 110         


Glu Arg Asp Ser Arg Glu His Glu Glu Pro Thr Thr Ser Glu Met Ala 
        115                 120                 125             


Glu Glu Thr Tyr Ser Pro Lys Ile Phe Arg Pro Lys His Thr Arg Ile 
    130                 135                 140                 


Ser Glu Leu Lys Ala Glu Ala Val Lys Lys Asp Arg Arg Lys Lys Leu 
145                 150                 155                 160 


Thr Gln Ser Lys Phe Val Gly Gly Ala Glu Asn Thr Ala His Pro Arg 
                165                 170                 175     


Ile Ile Ser Ala Pro Glu Met Arg Gln Glu Ser Glu Gln Gly Pro Cys 
            180                 185                 190         


Arg Arg His Met Glu Ala Ser Leu Gln Glu Leu Lys Ala Ser Pro Arg 
        195                 200                 205             


Met Val Pro Arg Ala Val Tyr Leu Pro Asn Cys Asp Arg Lys Gly Phe 
    210                 215                 220                 


Tyr Lys Arg Lys Gln Cys Lys Pro Ser Arg Gly Arg Lys Arg Gly Ile 
225                 230                 235                 240 


Cys Trp Cys Val Asp Lys Tyr Gly Met Lys Leu Pro Gly Met Glu Tyr 
                245                 250                 255     


Val Asp Gly Asp Phe Gln Cys His Thr Phe Asp Ser Ser Asn Val Glu 
            260                 265                 270         


<210>  6800
<211>  233
<212>  PRT
<213>  Homo Sapiens

<400>  6800

Met Val Leu Leu Thr Ala Val Leu Leu Leu Leu Ala Ala Tyr Ala Gly 
1               5                   10                  15      


Pro Ala Gln Ser Leu Gly Ser Phe Val His Cys Glu Pro Cys Asp Glu 
            20                  25                  30          


Lys Ala Leu Ser Met Cys Pro Pro Ser Pro Leu Gly Cys Glu Leu Val 
        35                  40                  45              


Lys Glu Pro Gly Cys Gly Cys Cys Met Thr Cys Ala Leu Ala Glu Gly 
    50                  55                  60                  


Gln Ser Cys Gly Val Tyr Thr Glu Arg Cys Ala Gln Gly Leu Arg Cys 
65                  70                  75                  80  


Leu Pro Arg Gln Asp Glu Glu Lys Pro Leu His Ala Leu Leu His Gly 
                85                  90                  95      


Arg Gly Val Cys Leu Asn Glu Lys Ser Tyr Arg Glu Gln Val Lys Ile 
            100                 105                 110         


Gly Cys Ala Pro Gly Gly Gln Arg His Ile Cys Phe Ser Leu Tyr Tyr 
        115                 120                 125             


Ser Pro His Pro Lys Leu Pro Ser Pro Gly Leu Trp Pro Cys Ala Pro 
    130                 135                 140                 


Trp Pro Thr Gly Ala Asp Pro Pro Ala Pro Ser Pro Ala Glu Arg Asp 
145                 150                 155                 160 


Ser Arg Glu His Glu Glu Pro Thr Thr Ser Glu Met Ala Glu Glu Thr 
                165                 170                 175     


Tyr Ser Pro Lys Ile Phe Arg Pro Lys His Thr Arg Ile Ser Glu Leu 
            180                 185                 190         


Lys Ala Glu Ala Val Lys Lys Asp Arg Arg Lys Lys Leu Thr Gln Ser 
        195                 200                 205             


Lys Phe Val Gly Gly Ala Glu Asn Thr Ala His Pro Arg Ile Ile Ser 
    210                 215                 220                 


Ala Pro Glu Met Arg Gln Glu Ser Glu 
225                 230             


<210>  6801
<211>  238
<212>  PRT
<213>  Homo Sapiens

<400>  6801

Met Thr Pro His Arg Leu Leu Pro Pro Leu Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Leu Leu Ala Ala Ser Pro Gly Gly Ala Leu Ala Arg Cys Pro Gly Cys 
            20                  25                  30          


Gly Gln Gly Val Gln Ala Gly Cys Pro Gly Gly Cys Val Glu Glu Glu 
        35                  40                  45              


Asp Gly Gly Ser Pro Ala Glu Gly Cys Ala Glu Ala Glu Gly Cys Leu 
    50                  55                  60                  


Arg Arg Glu Gly Gln Glu Cys Gly Val Tyr Thr Pro Asn Cys Ala Pro 
65                  70                  75                  80  


Gly Leu Gln Cys His Pro Pro Lys Asp Asp Glu Ala Pro Leu Arg Ala 
                85                  90                  95      


Leu Leu Leu Gly Arg Gly Arg Cys Leu Pro Ala Arg Ala Pro Ala Glu 
            100                 105                 110         


Glu Asn Pro Lys Glu Ser Lys Pro Gln Ala Gly Thr Ala Arg Pro Gln 
        115                 120                 125             


Asp Val Asn Arg Arg Asp Gln Gln Arg Asn Pro Gly Thr Ser Thr Thr 
    130                 135                 140                 


Pro Ser Gln Pro Asn Ser Ala Gly Val Gln Asp Thr Glu Met Gly Pro 
145                 150                 155                 160 


Cys Arg Arg His Leu Asp Ser Val Leu Gln Gln Leu Gln Thr Glu Val 
                165                 170                 175     


Tyr Arg Gly Ala Gln Thr Leu Tyr Val Pro Asn Cys Asp His Arg Gly 
            180                 185                 190         


Phe Tyr Arg Lys Arg Gln Cys Arg Ser Ser Gln Gly Gln Arg Arg Gly 
        195                 200                 205             


Pro Cys Trp Cys Val Asp Arg Met Gly Lys Ser Leu Pro Gly Ser Pro 
    210                 215                 220                 


Asp Gly Asn Gly Ser Ser Ser Cys Pro Thr Gly Ser Ser Gly 
225                 230                 235             


<210>  6802
<211>  240
<212>  PRT
<213>  Homo Sapiens

<400>  6802

Met Thr Pro His Arg Leu Leu Pro Pro Leu Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Leu Leu Ala Ala Ser Pro Gly Gly Ala Leu Ala Arg Cys Pro Gly Cys 
            20                  25                  30          


Gly Gln Gly Val Gln Ala Gly Cys Pro Gly Gly Cys Val Glu Glu Glu 
        35                  40                  45              


Asp Gly Gly Ser Pro Ala Glu Gly Cys Ala Glu Ala Glu Gly Cys Leu 
    50                  55                  60                  


Arg Arg Glu Gly Gln Glu Cys Gly Val Tyr Thr Pro Asn Cys Ala Pro 
65                  70                  75                  80  


Gly Leu Gln Cys His Pro Pro Lys Asp Asp Glu Ala Pro Leu Arg Ala 
                85                  90                  95      


Leu Leu Leu Gly Arg Gly Arg Cys Leu Pro Ala Arg Ala Pro Ala Val 
            100                 105                 110         


Ala Glu Glu Asn Pro Lys Glu Ser Lys Pro Gln Ala Gly Thr Ala Arg 
        115                 120                 125             


Pro Gln Asp Val Asn Arg Arg Asp Gln Gln Arg Asn Pro Gly Thr Ser 
    130                 135                 140                 


Thr Thr Pro Ser Gln Pro Asn Ser Ala Gly Val Gln Asp Thr Glu Met 
145                 150                 155                 160 


Gly Pro Cys Arg Arg His Leu Asp Ser Val Leu Gln Gln Leu Gln Thr 
                165                 170                 175     


Glu Val Tyr Arg Gly Ala Gln Thr Leu Tyr Val Pro Asn Cys Asp His 
            180                 185                 190         


Arg Gly Phe Tyr Arg Lys Arg Gln Cys Arg Ser Ser Gln Gly Gln Arg 
        195                 200                 205             


Arg Gly Pro Cys Trp Cys Val Asp Arg Met Gly Lys Ser Leu Pro Gly 
    210                 215                 220                 


Ser Pro Asp Gly Asn Gly Ser Ser Ser Cys Pro Thr Gly Ser Ser Gly 
225                 230                 235                 240 


<210>  6803
<211>  136
<212>  PRT
<213>  Homo Sapiens

<400>  6803

Met Thr Pro His Arg Leu Leu Pro Pro Leu Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Leu Leu Ala Ala Ser Pro Gly Gly Ala Leu Ala Arg Cys Pro Gly Cys 
            20                  25                  30          


Gly Gln Gly Val Gln Ala Gly Cys Pro Gly Gly Cys Val Glu Glu Glu 
        35                  40                  45              


Asp Gly Gly Ser Pro Ala Glu Gly Cys Ala Glu Ala Glu Gly Cys Leu 
    50                  55                  60                  


Arg Arg Glu Gly Gln Glu Cys Gly Val Tyr Thr Pro Asn Cys Ala Pro 
65                  70                  75                  80  


Gly Leu Gln Cys His Pro Pro Lys Asp Asp Glu Ala Pro Leu Arg Ala 
                85                  90                  95      


Leu Leu Leu Gly Arg Gly Arg Cys Leu Pro Ala Arg Ala Pro Ala Val 
            100                 105                 110         


Leu Ser Ser Pro Arg Thr Leu Arg Lys Leu Ser Pro Glu Pro Gly Ala 
        115                 120                 125             


Thr Cys Ser Cys Arg Gly Glu Ser 
    130                 135     


<210>  6804
<211>  282
<212>  PRT
<213>  Homo Sapiens

<400>  6804

Met Glu Arg Pro Ser Leu Arg Ala Leu Leu Leu Gly Ala Ala Gly Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Pro Leu Ser Ser Ser Ser Ser Ser Asp Thr Cys 
            20                  25                  30          


Gly Pro Cys Glu Pro Ala Ser Cys Pro Pro Leu Pro Pro Leu Gly Cys 
        35                  40                  45              


Leu Leu Gly Glu Thr Arg Asp Ala Cys Gly Cys Cys Pro Met Cys Ala 
    50                  55                  60                  


Arg Gly Glu Gly Glu Pro Cys Gly Gly Gly Gly Ala Gly Arg Gly Tyr 
65                  70                  75                  80  


Cys Ala Pro Gly Met Glu Cys Val Lys Ser Arg Lys Arg Arg Lys Gly 
                85                  90                  95      


Lys Ala Gly Ala Ala Ala Gly Gly Pro Gly Val Ser Gly Val Cys Val 
            100                 105                 110         


Cys Lys Ser Arg Tyr Pro Val Cys Gly Ser Asp Gly Thr Thr Tyr Pro 
        115                 120                 125             


Ser Gly Cys Gln Leu Arg Ala Ala Ser Gln Arg Ala Glu Ser Arg Gly 
    130                 135                 140                 


Glu Lys Ala Ile Thr Gln Val Ser Lys Gly Thr Cys Glu Gln Gly Pro 
145                 150                 155                 160 


Ser Ile Val Thr Pro Pro Lys Asp Ile Trp Asn Val Thr Gly Ala Gln 
                165                 170                 175     


Val Tyr Leu Ser Cys Glu Val Ile Gly Ile Pro Thr Pro Val Leu Ile 
            180                 185                 190         


Trp Asn Lys Val Lys Arg Gly His Tyr Gly Val Gln Arg Thr Glu Leu 
        195                 200                 205             


Leu Pro Gly Asp Arg Asp Asn Leu Ala Ile Gln Thr Arg Gly Gly Pro 
    210                 215                 220                 


Glu Lys His Glu Val Thr Gly Trp Val Leu Val Ser Pro Leu Ser Lys 
225                 230                 235                 240 


Glu Asp Ala Gly Glu Tyr Glu Cys His Ala Ser Asn Ser Gln Gly Gln 
                245                 250                 255     


Ala Ser Ala Ser Ala Lys Ile Thr Val Val Asp Ala Leu His Glu Ile 
            260                 265                 270         


Pro Val Lys Lys Gly Glu Gly Ala Glu Leu 
        275                 280         


<210>  6805
<211>  279
<212>  PRT
<213>  Homo Sapiens

<400>  6805

Met Glu Arg Pro Ser Leu Arg Ala Leu Leu Leu Gly Ala Ala Gly Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Pro Leu Ser Ser Ser Ser Ser Ser Asp Thr Cys 
            20                  25                  30          


Gly Pro Cys Glu Pro Ala Ser Cys Pro Pro Leu Pro Pro Leu Gly Cys 
        35                  40                  45              


Leu Leu Gly Glu Thr Arg Asp Ala Cys Gly Cys Cys Pro Met Cys Ala 
    50                  55                  60                  


Arg Gly Glu Gly Glu Pro Cys Gly Gly Gly Gly Ala Gly Arg Gly Tyr 
65                  70                  75                  80  


Cys Ala Pro Gly Met Glu Cys Val Lys Ser Arg Lys Arg Arg Lys Gly 
                85                  90                  95      


Lys Ala Gly Ala Ala Ala Gly Gly Pro Gly Val Ser Gly Val Cys Val 
            100                 105                 110         


Cys Lys Ser Arg Tyr Pro Val Cys Gly Ser Asp Gly Thr Thr Tyr Pro 
        115                 120                 125             


Ser Gly Cys Gln Leu Arg Ala Ala Ser Gln Arg Ala Glu Ser Arg Gly 
    130                 135                 140                 


Glu Lys Ala Ile Thr Gln Val Ser Lys Gly Thr Cys Glu Gln Gly Pro 
145                 150                 155                 160 


Ser Ile Val Thr Pro Pro Lys Asp Ile Trp Asn Val Thr Gly Ala Gln 
                165                 170                 175     


Val Tyr Leu Ser Cys Glu Val Ile Gly Ile Pro Thr Pro Val Leu Ile 
            180                 185                 190         


Trp Asn Lys Val Lys Arg Gly His Tyr Gly Val Gln Arg Thr Glu Leu 
        195                 200                 205             


Leu Pro Gly Asp Arg Asp Asn Leu Ala Ile Gln Thr Arg Gly Gly Pro 
    210                 215                 220                 


Glu Lys His Glu Val Thr Gly Trp Val Leu Val Ser Pro Leu Ser Lys 
225                 230                 235                 240 


Glu Asp Ala Gly Glu Tyr Glu Cys His Ala Ser Asn Ser Gln Gly Gln 
                245                 250                 255     


Ala Ser Ala Ser Ala Lys Ile Thr Val Val Asp Ala Leu His Glu Ile 
            260                 265                 270         


Pro Val Lys Lys Gly Thr Gln 
        275                 


<210>  6806
<211>  278
<212>  PRT
<213>  Homo Sapiens

<400>  6806

Met Pro Arg Leu Ser Leu Leu Leu Pro Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Pro Leu Leu Pro Pro Leu Ser Pro Ser Leu Gly Ile Arg Asp Val Gly 
            20                  25                  30          


Gly Arg Arg Pro Lys Cys Gly Pro Cys Arg Pro Glu Gly Cys Pro Ala 
        35                  40                  45              


Pro Ala Pro Cys Pro Ala Pro Gly Ile Ser Ala Leu Asp Glu Cys Gly 
    50                  55                  60                  


Cys Cys Ala Arg Cys Leu Gly Ala Glu Gly Ala Ser Cys Gly Gly Arg 
65                  70                  75                  80  


Ala Gly Gly Arg Cys Gly Pro Gly Leu Val Cys Ala Ser Gln Ala Ala 
                85                  90                  95      


Gly Ala Ala Pro Glu Gly Thr Gly Leu Cys Val Cys Ala Gln Arg Gly 
            100                 105                 110         


Thr Val Cys Gly Ser Asp Gly Arg Ser Tyr Pro Ser Val Cys Ala Leu 
        115                 120                 125             


Arg Leu Arg Ala Arg His Thr Pro Arg Ala His Pro Gly His Leu His 
    130                 135                 140                 


Lys Ala Arg Asp Gly Pro Cys Glu Phe Ala Pro Val Val Val Val Pro 
145                 150                 155                 160 


Pro Arg Ser Val His Asn Val Thr Gly Ala Gln Val Gly Leu Ser Cys 
                165                 170                 175     


Glu Val Arg Ala Val Pro Thr Pro Val Ile Thr Trp Arg Lys Val Thr 
            180                 185                 190         


Lys Ser Pro Glu Gly Thr Gln Ala Leu Glu Glu Leu Pro Gly Asp His 
        195                 200                 205             


Val Asn Ile Ala Val Gln Val Arg Gly Gly Pro Ser Asp His Glu Ala 
    210                 215                 220                 


Thr Ala Trp Ile Leu Ile Asn Pro Leu Arg Lys Glu Asp Glu Gly Val 
225                 230                 235                 240 


Tyr Gln Cys His Ala Ala Asn Met Val Gly Glu Ala Glu Ser His Ser 
                245                 250                 255     


Thr Val Thr Val Leu Asp Leu Ser Lys Tyr Arg Ser Phe His Phe Pro 
            260                 265                 270         


Ala Pro Asp Asp Arg Met 
        275             


<210>  6807
<211>  110
<212>  PRT
<213>  Homo Sapiens

<400>  6807

Met Ala Pro Arg Gly Cys Ile Val Ala Val Phe Ala Ile Phe Cys Ile 
1               5                   10                  15      


Ser Arg Leu Leu Cys Ser His Gly Ala Pro Val Ala Pro Met Thr Pro 
            20                  25                  30          


Tyr Leu Met Leu Cys Gln Pro His Lys Arg Cys Gly Asp Lys Phe Tyr 
        35                  40                  45              


Asp Pro Leu Gln His Cys Cys Tyr Asp Asp Ala Val Val Pro Leu Ala 
    50                  55                  60                  


Arg Thr Gln Thr Cys Gly Asn Cys Thr Phe Arg Val Cys Phe Glu Gln 
65                  70                  75                  80  


Cys Cys Pro Trp Thr Phe Met Val Lys Leu Ile Asn Gln Asn Cys Asp 
                85                  90                  95      


Ser Ala Arg Thr Ser Asp Asp Arg Leu Cys Arg Ser Val Ser 
            100                 105                 110 


<210>  6808
<211>  130
<212>  PRT
<213>  Homo Sapiens

<400>  6808

Met Arg Phe Ser Val Ser Gly Met Arg Thr Asp Tyr Pro Arg Ser Val 
1               5                   10                  15      


Leu Ala Pro Ala Tyr Val Ser Val Cys Leu Leu Leu Leu Cys Pro Arg 
            20                  25                  30          


Glu Val Ile Ala Pro Ala Gly Ser Glu Pro Trp Leu Cys Gln Pro Ala 
        35                  40                  45              


Pro Arg Cys Gly Asp Lys Ile Tyr Asn Pro Leu Glu Gln Cys Cys Tyr 
    50                  55                  60                  


Asn Asp Ala Ile Val Ser Leu Ser Glu Thr Arg Gln Cys Gly Pro Pro 
65                  70                  75                  80  


Cys Thr Phe Trp Pro Cys Phe Glu Leu Cys Cys Leu Asp Ser Phe Gly 
                85                  90                  95      


Leu Thr Asn Asp Phe Val Val Lys Leu Lys Val Gln Gly Val Asn Ser 
            100                 105                 110         


Gln Cys His Ser Ser Pro Ile Ser Ser Lys Cys Glu Ser Arg Arg Arg 
        115                 120                 125             


Phe Pro 
    130 


<210>  6809
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  6809

Met Val Pro Arg Ile Phe Ala Pro Ala Tyr Val Ser Val Cys Leu Leu 
1               5                   10                  15      


Leu Leu Cys Pro Arg Glu Val Ile Ala Pro Ala Gly Ser Glu Pro Trp 
            20                  25                  30          


Leu Cys Gln Pro Ala Pro Arg Cys Gly Asp Lys Ile Tyr Asn Pro Leu 
        35                  40                  45              


Glu Gln Cys Cys Tyr Asn Asp Ala Ile Val Ser Leu Ser Glu Thr Arg 
    50                  55                  60                  


Gln Cys Gly Pro Pro Cys Thr Phe Trp Pro Cys Phe Glu Leu Cys Cys 
65                  70                  75                  80  


Leu Asp Ser Phe Gly Leu Thr Asn Asp Phe Val Val Lys Leu Lys Val 
                85                  90                  95      


Gln Gly Val Asn Ser Gln Cys His Ser Ser Pro Ile Ser Ser Lys Cys 
            100                 105                 110         


Glu Ser Arg Arg Arg Phe Pro 
        115                 


<210>  6810
<211>  84
<212>  PRT
<213>  Homo Sapiens

<400>  6810

Gln Pro Ala Pro Arg Cys Gly Asp Lys Ile Tyr Asn Pro Leu Glu Gln 
1               5                   10                  15      


Cys Cys Tyr Asn Asp Ala Ile Val Ser Leu Ser Glu Thr Arg Gln Cys 
            20                  25                  30          


Gly Pro Pro Cys Thr Phe Trp Pro Cys Phe Glu Leu Cys Cys Leu Asp 
        35                  40                  45              


Ser Phe Gly Leu Thr Asn Asp Phe Val Val Lys Leu Lys Val Gln Gly 
    50                  55                  60                  


Val Asn Ser Gln Cys His Ser Ser Pro Ile Ser Ser Lys Cys Glu Arg 
65                  70                  75                  80  


Arg Arg Phe Pro 
                


<210>  6811
<211>  125
<212>  PRT
<213>  Homo Sapiens

<400>  6811

Met Arg Pro Arg Cys Cys Ile Leu Ala Leu Val Cys Trp Ile Thr Val 
1               5                   10                  15      


Phe Leu Leu Gln Cys Ser Lys Gly Thr Thr Asp Ala Pro Val Gly Ser 
            20                  25                  30          


Gly Leu Trp Leu Cys Gln Pro Thr Pro Arg Cys Gly Asn Lys Ile Tyr 
        35                  40                  45              


Asn Pro Ser Glu Gln Cys Cys Tyr Asp Asp Ala Ile Leu Ser Leu Lys 
    50                  55                  60                  


Glu Thr Arg Arg Cys Gly Ser Thr Cys Thr Phe Trp Pro Cys Phe Glu 
65                  70                  75                  80  


Leu Cys Cys Pro Glu Ser Phe Gly Pro Gln Gln Lys Phe Leu Val Lys 
                85                  90                  95      


Leu Arg Val Leu Gly Met Lys Ser Gln Cys His Leu Ser Pro Ile Ser 
            100                 105                 110         


Arg Ser Cys Thr Arg Asn Arg Arg His Val Leu Tyr Pro 
        115                 120                 125 


<210>  6812
<211>  16
<212>  PRT
<213>  Homo Sapiens

<400>  6812

Met Gly Pro Gly Arg Cys Leu Leu Thr Ala Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


<210>  6813
<211>  132
<212>  PRT
<213>  Homo Sapiens

<400>  6813

Met Gly Pro Gly Arg Cys Leu Leu Thr Ala Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Ala Pro Pro Pro Glu Ala Ser Gln Tyr Cys Gly Arg Leu Glu Tyr Trp 
            20                  25                  30          


Asn Pro Asp Asn Lys Cys Cys Ser Ser Cys Leu Gln Arg Phe Gly Pro 
        35                  40                  45              


Pro Pro Cys Pro Asp Tyr Glu Phe Arg Glu Asn Cys Gly Leu Asn Asp 
    50                  55                  60                  


His Gly Asp Phe Val Thr Pro Pro Phe Arg Lys Cys Ser Ser Gly Gln 
65                  70                  75                  80  


Cys Asn Pro Asp Gly Ala Glu Leu Cys Ser Pro Cys Gly Gly Gly Ala 
                85                  90                  95      


Val Thr Pro Thr Pro Ala Ala Gly Gly Gly Arg Thr Pro Trp Arg Cys 
            100                 105                 110         


Arg Glu Ala Gly Pro Cys Gln Gly Ala Leu Pro Pro His Thr Trp Lys 
        115                 120                 125             


Pro Arg Arg Pro 
    130         


<210>  6814
<211>  138
<212>  PRT
<213>  Homo Sapiens

<400>  6814

Met Gly Pro Gly Arg Cys Leu Leu Thr Ala Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Ala Pro Pro Pro Glu Ala Ser Gln Tyr Cys Gly Arg Leu Glu Tyr Trp 
            20                  25                  30          


Asn Pro Asp Asn Lys Cys Cys Ser Ser Cys Leu Gln Arg Phe Gly Pro 
        35                  40                  45              


Pro Pro Cys Pro Asp Tyr Glu Phe Arg Glu Asn Cys Gly Leu Asn Asp 
    50                  55                  60                  


His Gly Asp Phe Val Thr Pro Pro Phe Arg Lys Cys Ser Ser Gly Gln 
65                  70                  75                  80  


Cys Asn Pro Asp Gly Ala Glu Leu Cys Ser Pro Cys Gly Gly Gly Ala 
                85                  90                  95      


Val Thr Pro Thr Pro Ala Ala Gly Gly Gly Arg Thr Pro Trp Arg Cys 
            100                 105                 110         


Arg Glu Arg Pro Val Pro Ala Lys Gly His Cys Pro Leu Thr Pro Gly 
        115                 120                 125             


Asn Pro Gly Ala Pro Ser Ser Gln Glu Arg 
    130                 135             


<210>  6815
<211>  355
<212>  PRT
<213>  Homo Sapiens

<400>  6815

Met Gly Pro Gly Arg Cys Leu Leu Thr Ala Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Ala Pro Pro Pro Glu Ala Ser Gln Tyr Cys Gly Arg Leu Glu Tyr Trp 
            20                  25                  30          


Asn Pro Asp Asn Lys Cys Cys Ser Ser Cys Leu Gln Arg Phe Gly Pro 
        35                  40                  45              


Pro Pro Cys Pro Asp Tyr Glu Phe Arg Glu Asn Cys Gly Leu Asn Asp 
    50                  55                  60                  


His Gly Asp Phe Val Thr Pro Pro Phe Arg Lys Cys Ser Ser Gly Gln 
65                  70                  75                  80  


Cys Asn Pro Asp Gly Ala Glu Leu Cys Ser Pro Cys Gly Gly Gly Ala 
                85                  90                  95      


Val Thr Pro Thr Pro Ala Ala Gly Gly Gly Arg Thr Pro Trp Arg Cys 
            100                 105                 110         


Arg Glu Arg Pro Val Pro Ala Lys Gly His Cys Pro Leu Thr Pro Gly 
        115                 120                 125             


Asn Pro Gly Ala Pro Ser Ser Gln Glu Arg Ser Ser Pro Ala Ser Ser 
    130                 135                 140                 


Ile Ala Trp Arg Thr Pro Glu Pro Val Pro Gln Gln Ala Trp Pro Asn 
145                 150                 155                 160 


Phe Leu Pro Leu Val Val Leu Val Leu Leu Leu Thr Leu Ala Val Ile 
                165                 170                 175     


Ala Ile Leu Leu Phe Ile Leu Leu Trp His Leu Cys Trp Pro Lys Glu 
            180                 185                 190         


Lys Ala Asp Pro Tyr Pro Tyr Pro Gly Leu Val Cys Gly Val Pro Asn 
        195                 200                 205             


Thr His Thr Pro Ser Ser Ser His Leu Ser Ser Pro Gly Ala Leu Glu 
    210                 215                 220                 


Thr Gly Asp Thr Trp Lys Glu Ala Ser Leu Leu Pro Leu Leu Ser Arg 
225                 230                 235                 240 


Glu Leu Ser Ser Leu Ala Ser Gln Pro Leu Ser Arg Leu Leu Asp Glu 
                245                 250                 255     


Leu Glu Val Leu Glu Glu Leu Ile Val Leu Leu Asp Pro Glu Pro Gly 
            260                 265                 270         


Pro Gly Gly Gly Met Ala His Gly Thr Thr Arg His Leu Ala Ala Arg 
        275                 280                 285             


Tyr Gly Leu Pro Ala Ala Trp Ser Thr Phe Ala Tyr Ser Leu Arg Pro 
    290                 295                 300                 


Ser Arg Ser Pro Leu Arg Ala Leu Ile Glu Met Val Val Ala Arg Glu 
305                 310                 315                 320 


Pro Ser Ala Ser Leu Gly Gln Leu Gly Thr His Leu Ala Gln Leu Gly 
                325                 330                 335     


Arg Ala Asp Ala Leu Arg Val Leu Ser Lys Leu Gly Ser Ser Gly Val 
            340                 345                 350         


Cys Trp Ala 
        355 


<210>  6816
<211>  355
<212>  PRT
<213>  Homo Sapiens

<400>  6816

Met Gly Pro Gly Arg Cys Leu Leu Thr Ala Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Ala Pro Pro Pro Glu Ala Ser Gln Tyr Cys Gly Arg Leu Glu Tyr Trp 
            20                  25                  30          


Asn Pro Asp Asn Lys Cys Cys Ser Ser Cys Leu Gln Arg Phe Gly Pro 
        35                  40                  45              


Pro Pro Cys Pro Asp Tyr Glu Phe Arg Glu Asn Cys Gly Leu Asn Asp 
    50                  55                  60                  


His Gly Asp Phe Val Thr Pro Pro Phe Arg Lys Cys Ser Ser Gly Gln 
65                  70                  75                  80  


Cys Asn Pro Asp Gly Ala Glu Leu Cys Ser Pro Cys Gly Gly Gly Ala 
                85                  90                  95      


Val Thr Pro Thr Pro Ala Ala Gly Gly Gly Arg Thr Pro Trp Arg Cys 
            100                 105                 110         


Arg Glu Arg Pro Val Pro Ala Lys Gly His Cys Pro Leu Thr Pro Gly 
        115                 120                 125             


Asn Pro Gly Ala Pro Ser Ser Gln Glu Arg Ser Ser Pro Ala Ser Ser 
    130                 135                 140                 


Ile Ala Trp Arg Thr Pro Glu Pro Val Pro Gln Gln Ala Trp Pro Asn 
145                 150                 155                 160 


Phe Leu Pro Leu Val Val Leu Val Leu Leu Leu Thr Leu Ala Val Ile 
                165                 170                 175     


Ala Ile Leu Leu Phe Ile Leu Leu Trp His Leu Cys Trp Pro Lys Glu 
            180                 185                 190         


Lys Ala Asp Pro Tyr Pro Tyr Pro Gly Leu Val Cys Gly Val Pro Asn 
        195                 200                 205             


Thr His Thr Pro Ser Ser Ser His Leu Ser Ser Pro Gly Ala Leu Glu 
    210                 215                 220                 


Thr Gly Asp Thr Trp Lys Glu Ala Ser Leu Leu Pro Leu Leu Ser Arg 
225                 230                 235                 240 


Glu Leu Ser Ser Leu Ala Ser Gln Pro Leu Ser Arg Leu Leu Asp Glu 
                245                 250                 255     


Leu Glu Val Leu Glu Glu Leu Ile Val Leu Leu Asp Pro Glu Pro Gly 
            260                 265                 270         


Pro Gly Gly Gly Met Ala His Gly Thr Thr Arg His Leu Ala Ala Arg 
        275                 280                 285             


Tyr Gly Leu Pro Ala Ala Trp Ser Thr Phe Ala Tyr Ser Leu Arg Pro 
    290                 295                 300                 


Ser Arg Ser Pro Leu Arg Ala Leu Ile Glu Met Val Val Ala Arg Glu 
305                 310                 315                 320 


Pro Ser Ala Ser Leu Gly Gln Leu Gly Thr His Leu Ala Gln Leu Gly 
                325                 330                 335     


Arg Ala Asp Ala Leu Arg Val Leu Ser Lys Leu Gly Ser Ser Gly Val 
            340                 345                 350         


Cys Trp Ala 
        355 


<210>  6817
<211>  167
<212>  PRT
<213>  Homo Sapiens

<400>  6817

Met Gly Pro Gly Arg Cys Leu Leu Thr Ala Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Ala Pro Pro Pro Glu Ala Ser Gln Tyr Cys Gly Arg Leu Glu Tyr Trp 
            20                  25                  30          


Asn Pro Asp Asn Lys Cys Cys Ser Ser Cys Leu Gln Arg Phe Gly Pro 
        35                  40                  45              


Pro Pro Cys Pro Glu Leu Ser Ser Leu Ala Ser Gln Pro Leu Ser Arg 
    50                  55                  60                  


Leu Leu Asp Glu Leu Glu Val Leu Glu Glu Leu Ile Val Leu Leu Asp 
65                  70                  75                  80  


Pro Glu Pro Gly Pro Gly Gly Gly Met Ala His Gly Thr Thr Arg His 
                85                  90                  95      


Leu Ala Ala Arg Tyr Gly Leu Pro Ala Ala Trp Ser Thr Phe Ala Tyr 
            100                 105                 110         


Ser Leu Arg Pro Ser Arg Ser Pro Leu Arg Ala Leu Ile Glu Met Val 
        115                 120                 125             


Val Ala Arg Glu Pro Ser Ala Ser Leu Gly Gln Leu Gly Thr His Leu 
    130                 135                 140                 


Ala Gln Leu Gly Arg Ala Asp Ala Leu Arg Val Leu Ser Lys Leu Gly 
145                 150                 155                 160 


Ser Ser Gly Val Cys Trp Ala 
                165         


<210>  6818
<211>  187
<212>  PRT
<213>  Homo Sapiens

<400>  6818

Met Gly Pro Gly Arg Cys Leu Leu Thr Ala Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Ala Pro Pro Pro Glu Ala Ser Gln Tyr Cys Gly Arg Leu Glu Tyr Trp 
            20                  25                  30          


Asn Pro Asp Asn Lys Cys Cys Ser Ser Cys Leu Gln Arg Phe Gly Pro 
        35                  40                  45              


Pro Pro Cys Pro Gly Ala Leu Glu Thr Gly Asp Thr Trp Lys Glu Ala 
    50                  55                  60                  


Ser Leu Leu Pro Leu Leu Ser Arg Glu Leu Ser Ser Leu Ala Ser Gln 
65                  70                  75                  80  


Pro Leu Ser Arg Leu Leu Asp Glu Leu Glu Val Leu Glu Glu Leu Ile 
                85                  90                  95      


Val Leu Leu Asp Pro Glu Pro Gly Pro Gly Gly Gly Met Ala His Gly 
            100                 105                 110         


Thr Thr Arg His Leu Ala Ala Arg Tyr Gly Leu Pro Ala Ala Trp Ser 
        115                 120                 125             


Thr Phe Ala Tyr Ser Leu Arg Pro Ser Arg Ser Pro Leu Arg Ala Leu 
    130                 135                 140                 


Ile Glu Met Val Val Ala Arg Glu Pro Ser Ala Ser Leu Gly Gln Leu 
145                 150                 155                 160 


Gly Thr His Leu Ala Gln Leu Gly Arg Ala Asp Ala Leu Arg Val Leu 
                165                 170                 175     


Ser Lys Leu Gly Ser Ser Gly Val Cys Trp Ala 
            180                 185         


<210>  6819
<211>  60
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6819

Xaa Gly Arg Leu Glu Tyr Trp Asn Pro Asp Asn Lys Cys Cys Ser Ser 
1               5                   10                  15      


Cys Leu Gln Arg Phe Gly Pro Pro Pro Cys Pro Gly Glu Asn Pro Arg 
            20                  25                  30          


Pro Ser Leu Ala Trp Ala Glu Leu Ala Glu Ala Gly Pro Cys Gln Gly 
        35                  40                  45              


Ala Leu Pro Pro His Thr Trp Lys Pro Arg Arg Pro 
    50                  55                  60  


<210>  6820
<211>  74
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6820

Xaa Asn Cys Gly Leu Asn Asp His Gly Asp Phe Val Thr Pro Pro Phe 
1               5                   10                  15      


Arg Lys Cys Ser Ser Gly Gln Cys Asn Pro Asp Gly Ala Glu Leu Cys 
            20                  25                  30          


Ser Pro Cys Gly Gly Gly Ala Val Thr Pro Thr Pro Ala Ala Gly Gly 
        35                  40                  45              


Gly Arg Thr Pro Trp Arg Cys Arg Glu Ala Pro Trp Arg Gln Gly Thr 
    50                  55                  60                  


His Gly Arg Arg Pro His Tyr Phe His Ser 
65                  70                  


<210>  6821
<211>  53
<212>  PRT
<213>  Homo Sapiens

<400>  6821

Met Cys Ser Tyr Tyr His Met Lys Lys Arg Ser Val Ser Gly Cys Asn 
1               5                   10                  15      


Ile Thr Ile Phe Ala Val Met Phe Ser His Leu Ser Ala Gly Lys Ser 
            20                  25                  30          


Pro Cys Gly Asn Gln Ala Asn Val Leu Cys Ile Ser Arg Leu Glu Phe 
        35                  40                  45              


Val Gln Tyr Gln Ser 
    50              


<210>  6822
<211>  336
<212>  PRT
<213>  Homo Sapiens

<400>  6822

Met Pro Pro Pro Ala Pro Gly Ala Arg Leu Arg Leu Leu Ala Ala Ala 
1               5                   10                  15      


Ala Leu Ala Gly Leu Ala Val Ile Ser Arg Gly Leu Leu Ser Gln Ser 
            20                  25                  30          


Leu Glu Phe Asn Ser Pro Ala Asp Asn Tyr Thr Val Cys Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Leu Ser Cys Phe Ile Asp Glu His Val Thr Arg Val Ala 
    50                  55                  60                  


Trp Leu Asn Arg Ser Asn Ile Leu Tyr Ala Gly Asn Asp Arg Trp Thr 
65                  70                  75                  80  


Ser Asp Pro Arg Val Arg Leu Leu Ile Asn Thr Pro Glu Glu Phe Ser 
                85                  90                  95      


Ile Leu Ile Thr Glu Val Gly Leu Gly Asp Glu Gly Leu Tyr Thr Cys 
            100                 105                 110         


Ser Phe Gln Thr Arg His Gln Pro Tyr Thr Thr Gln Val Tyr Leu Ile 
        115                 120                 125             


Val His Val Pro Ala Arg Ile Val Asn Ile Ser Ser Pro Val Thr Val 
    130                 135                 140                 


Asn Glu Gly Gly Asn Val Asn Leu Leu Cys Leu Ala Val Gly Arg Pro 
145                 150                 155                 160 


Glu Pro Thr Val Thr Trp Arg Gln Leu Arg Asp Gly Phe Thr Ser Glu 
                165                 170                 175     


Gly Glu Ile Leu Glu Ile Ser Asp Ile Gln Arg Gly Gln Ala Gly Glu 
            180                 185                 190         


Tyr Glu Cys Val Thr His Asn Gly Val Asn Ser Ala Pro Asp Ser Arg 
        195                 200                 205             


Arg Val Leu Val Thr Val Asn Tyr Pro Pro Thr Ile Thr Asp Val Thr 
    210                 215                 220                 


Ser Ala Arg Thr Ala Leu Gly Arg Ala Ala Leu Leu Arg Cys Glu Ala 
225                 230                 235                 240 


Met Ala Val Pro Pro Ala Asp Phe Gln Trp Tyr Lys Asp Asp Arg Leu 
                245                 250                 255     


Leu Ser Ser Gly Thr Ala Glu Gly Leu Lys Val Gln Thr Glu Arg Thr 
            260                 265                 270         


Arg Ser Met Leu Leu Phe Ala Asn Val Ser Ala Arg His Tyr Gly Asn 
        275                 280                 285             


Tyr Thr Cys Arg Ala Ala Asn Arg Leu Gly Ala Ser Ser Ala Ser Met 
    290                 295                 300                 


Arg Leu Leu Arg Pro Gly Ser Leu Glu Asn Ser Ala Pro Arg Pro Pro 
305                 310                 315                 320 


Gly Leu Leu Ala Leu Leu Ser Ala Leu Gly Trp Leu Trp Trp Arg Met 
                325                 330                 335     


<210>  6823
<211>  1327
<212>  PRT
<213>  Homo Sapiens

<400>  6823

Met Thr Leu Asp Arg Pro Gly Glu Gly Ala Thr Met Leu Lys Thr Phe 
1               5                   10                  15      


Thr Val Leu Leu Phe Cys Ile Leu Met Asp Pro Gln Pro Glu Leu Trp 
            20                  25                  30          


Ile Glu Ser Asn Tyr Pro Gln Ala Pro Trp Glu Asn Ile Thr Leu Trp 
        35                  40                  45              


Cys Arg Ser Pro Ser Arg Ile Ser Ser Lys Phe Leu Leu Leu Lys Asp 
    50                  55                  60                  


Lys Thr Gln Met Thr Trp Ile Arg Pro Ser His Lys Thr Phe Gln Val 
65                  70                  75                  80  


Ser Phe Leu Ile Gly Ala Leu Thr Glu Ser Asn Ala Gly Leu Tyr Arg 
                85                  90                  95      


Cys Cys Tyr Trp Lys Glu Thr Gly Trp Ser Lys Pro Ser Lys Val Leu 
            100                 105                 110         


Glu Leu Glu Ala Pro Gly Gln Leu Pro Lys Pro Ile Phe Trp Ile Gln 
        115                 120                 125             


Ala Glu Thr Pro Ala Leu Pro Gly Cys Asn Val Asn Ile Leu Cys His 
    130                 135                 140                 


Gly Trp Leu Gln Asp Leu Val Phe Met Leu Phe Lys Glu Gly Tyr Ala 
145                 150                 155                 160 


Glu Pro Val Asp Tyr Gln Val Pro Thr Gly Thr Met Ala Ile Phe Ser 
                165                 170                 175     


Ile Asp Asn Leu Thr Pro Glu Asp Glu Gly Val Tyr Ile Cys Arg Thr 
            180                 185                 190         


His Ile Gln Met Leu Pro Thr Leu Trp Ser Glu Pro Ser Asn Pro Leu 
        195                 200                 205             


Lys Leu Val Val Ala Gly Leu Tyr Pro Lys Pro Thr Leu Thr Ala His 
    210                 215                 220                 


Pro Gly Pro Ile Met Ala Pro Gly Glu Ser Leu Asn Leu Arg Cys Gln 
225                 230                 235                 240 


Gly Pro Ile Tyr Gly Met Thr Phe Ala Leu Met Arg Val Glu Asp Leu 
                245                 250                 255     


Glu Lys Ser Phe Tyr His Lys Lys Thr Ile Lys Asn Glu Ala Asn Phe 
            260                 265                 270         


Phe Phe Gln Ser Leu Lys Ile Gln Asp Thr Gly His Tyr Leu Cys Phe 
        275                 280                 285             


Tyr Tyr Asp Ala Ser Tyr Arg Gly Ser Leu Leu Ser Asp Val Leu Lys 
    290                 295                 300                 


Ile Trp Val Thr Asp Thr Phe Pro Lys Thr Trp Leu Leu Ala Arg Pro 
305                 310                 315                 320 


Ser Ala Val Val Gln Met Gly Gln Asn Val Ser Leu Arg Cys Arg Gly 
                325                 330                 335     


Pro Val Asp Gly Val Gly Leu Ala Leu Tyr Lys Lys Gly Glu Asp Lys 
            340                 345                 350         


Pro Leu Gln Phe Leu Asp Ala Thr Ser Ile Asp Asp Asn Thr Ser Phe 
        355                 360                 365             


Phe Leu Asn Asn Val Thr Tyr Ser Asp Thr Gly Ile Tyr Ser Cys His 
    370                 375                 380                 


Tyr Leu Leu Thr Trp Lys Thr Ser Ile Arg Met Pro Ser His Asn Thr 
385                 390                 395                 400 


Val Glu Leu Met Val Val Asp Lys Pro Pro Lys Pro Ser Leu Ser Ala 
                405                 410                 415     


Trp Pro Ser Thr Val Phe Lys Leu Gly Lys Ala Ile Thr Leu Gln Cys 
            420                 425                 430         


Arg Val Ser His Pro Val Leu Glu Phe Ser Leu Glu Trp Glu Glu Arg 
        435                 440                 445             


Glu Thr Phe Gln Lys Phe Ser Val Asn Gly Asp Phe Ile Ile Ser Asn 
    450                 455                 460                 


Val Asp Gly Lys Gly Thr Gly Thr Tyr Ser Cys Ser Tyr Arg Val Glu 
465                 470                 475                 480 


Thr His Pro Asn Ile Trp Ser His Arg Ser Glu Pro Leu Lys Leu Met 
                485                 490                 495     


Gly Pro Ala Gly Tyr Leu Thr Trp Asn Tyr Val Leu Asn Glu Ala Ile 
            500                 505                 510         


Arg Leu Ser Leu Ile Met Gln Leu Val Ala Leu Leu Leu Val Val Leu 
        515                 520                 525             


Trp Ile Arg Trp Lys Cys Arg Arg Leu Arg Ile Arg Glu Ala Trp Leu 
    530                 535                 540                 


Leu Gly Thr Ala Gln Gly Val Thr Met Leu Phe Ile Val Thr Ala Leu 
545                 550                 555                 560 


Leu Cys Cys Gly Leu Cys Asn Gly Val Leu Ile Glu Glu Thr Glu Ile 
                565                 570                 575     


Val Met Pro Thr Pro Lys Pro Glu Leu Trp Ala Glu Thr Asn Phe Pro 
            580                 585                 590         


Leu Ala Pro Trp Lys Asn Leu Thr Leu Trp Cys Arg Ser Pro Ser Gly 
        595                 600                 605             


Ser Thr Lys Glu Phe Val Leu Leu Lys Asp Gly Thr Gly Trp Ile Ala 
    610                 615                 620                 


Thr Arg Pro Ala Ser Glu Gln Val Arg Ala Ala Phe Pro Leu Gly Ala 
625                 630                 635                 640 


Leu Thr Gln Ser His Thr Gly Ser Tyr His Cys His Ser Trp Glu Glu 
                645                 650                 655     


Met Ala Val Ser Glu Pro Ser Glu Ala Leu Glu Leu Val Gly Thr Asp 
            660                 665                 670         


Ile Leu Pro Lys Pro Val Ile Ser Ala Ser Pro Thr Ile Arg Gly Gln 
        675                 680                 685             


Glu Leu Gln Leu Arg Cys Lys Gly Trp Leu Ala Gly Met Gly Phe Ala 
    690                 695                 700                 


Leu Tyr Lys Glu Gly Glu Gln Glu Pro Val Gln Gln Leu Gly Ala Val 
705                 710                 715                 720 


Gly Arg Glu Ala Phe Phe Thr Ile Gln Arg Met Glu Asp Lys Asp Glu 
                725                 730                 735     


Gly Asn Tyr Ser Cys Arg Thr His Thr Glu Lys Arg Pro Phe Lys Trp 
            740                 745                 750         


Ser Glu Pro Ser Glu Pro Leu Glu Leu Val Ile Lys Glu Met Tyr Pro 
        755                 760                 765             


Lys Pro Phe Phe Lys Thr Trp Ala Ser Pro Val Val Thr Pro Gly Ala 
    770                 775                 780                 


Arg Val Thr Phe Asn Cys Ser Thr Pro His Gln His Met Ser Phe Ile 
785                 790                 795                 800 


Leu Tyr Lys Asp Gly Ser Glu Ile Ala Ser Ser Asp Arg Ser Trp Ala 
                805                 810                 815     


Ser Pro Gly Ala Ser Ala Ala His Phe Leu Ile Ile Ser Val Gly Ile 
            820                 825                 830         


Gly Asp Gly Gly Asn Tyr Ser Cys Arg Tyr Tyr Asp Phe Ser Ile Trp 
        835                 840                 845             


Ser Glu Pro Ser Asp Pro Val Glu Leu Val Val Thr Glu Phe Tyr Pro 
    850                 855                 860                 


Lys Pro Thr Leu Leu Ala Gln Pro Gly Pro Val Val Phe Pro Gly Lys 
865                 870                 875                 880 


Ser Val Ile Leu Arg Cys Gln Gly Thr Phe Gln Gly Met Arg Phe Ala 
                885                 890                 895     


Leu Leu Gln Glu Gly Ala His Val Pro Leu Gln Phe Arg Ser Val Ser 
            900                 905                 910         


Gly Asn Ser Ala Asp Phe Leu Leu His Thr Val Gly Ala Glu Asp Ser 
        915                 920                 925             


Gly Asn Tyr Ser Cys Ile Tyr Tyr Glu Thr Thr Met Ser Asn Arg Gly 
    930                 935                 940                 


Ser Tyr Leu Ser Met Pro Leu Met Ile Trp Val Thr Asp Thr Phe Pro 
945                 950                 955                 960 


Lys Pro Trp Leu Phe Ala Glu Pro Ser Ser Val Val Pro Met Gly Gln 
                965                 970                 975     


Asn Val Thr Leu Trp Cys Arg Gly Pro Val His Gly Val Gly Tyr Ile 
            980                 985                 990         


Leu His Lys Glu Gly Glu Ala Thr  Ser Met Gln Leu Trp  Gly Ser Thr 
        995                 1000                 1005             


Ser Asn  Asp Gly Ala Phe Pro  Ile Thr Asn Ile Ser  Gly Thr Ser 
    1010                 1015                 1020             


Met Gly  Arg Tyr Ser Cys Cys  Tyr His Pro Asp Trp  Thr Ser Ser 
    1025                 1030                 1035             


Ile Lys  Ile Gln Pro Ser Asn  Thr Leu Glu Leu Leu  Val Thr Gly 
    1040                 1045                 1050             


Leu Leu  Pro Lys Pro Ser Leu  Leu Ala Gln Pro Gly  Pro Met Val 
    1055                 1060                 1065             


Ala Pro  Gly Glu Asn Met Thr  Leu Gln Cys Gln Gly  Glu Leu Pro 
    1070                 1075                 1080             


Asp Ser  Thr Phe Val Leu Leu  Lys Glu Gly Ala Gln  Glu Pro Leu 
    1085                 1090                 1095             


Glu Gln  Gln Arg Pro Ser Gly  Tyr Arg Ala Asp Phe  Trp Met Pro 
    1100                 1105                 1110             


Ala Val  Arg Gly Glu Asp Ser  Gly Ile Tyr Ser Cys  Val Tyr Tyr 
    1115                 1120                 1125             


Leu Asp  Ser Thr Pro Phe Ala  Ala Ser Asn His Ser  Asp Ser Leu 
    1130                 1135                 1140             


Glu Ile  Trp Val Thr Asp Lys  Pro Pro Lys Pro Ser  Leu Ser Ala 
    1145                 1150                 1155             


Trp Pro  Ser Thr Met Phe Lys  Leu Gly Lys Asp Ile  Thr Leu Gln 
    1160                 1165                 1170             


Cys Arg  Gly Pro Leu Pro Gly  Val Glu Phe Val Leu  Glu His Asp 
    1175                 1180                 1185             


Gly Glu  Glu Ala Pro Gln Gln  Phe Ser Glu Asp Gly  Asp Phe Val 
    1190                 1195                 1200             


Ile Asn  Asn Val Glu Gly Lys  Gly Ile Gly Asn Tyr  Ser Cys Ser 
    1205                 1210                 1215             


Tyr Arg  Leu Gln Ala Tyr Pro  Asp Ile Trp Ser Glu  Pro Ser Asp 
    1220                 1225                 1230             


Pro Leu  Glu Leu Val Gly Ala  Ala Gly Pro Val Ala  Gln Glu Cys 
    1235                 1240                 1245             


Thr Val  Gly Asn Ile Val Arg  Ser Ser Leu Ile Val  Val Val Val 
    1250                 1255                 1260             


Val Ala  Leu Gly Val Val Leu  Ala Ile Glu Trp Lys  Lys Trp Pro 
    1265                 1270                 1275             


Arg Leu  Arg Thr Arg Gly Ser  Glu Thr Asp Gly Arg  Asp Gln Thr 
    1280                 1285                 1290             


Ile Ala  Leu Glu Glu Cys Asn  Gln Glu Gly Glu Pro  Gly Thr Pro 
    1295                 1300                 1305             


Ala Asn  Ser Pro Ser Ser Thr  Ser Gln Arg Ile Ser  Val Glu Leu 
    1310                 1315                 1320             


Pro Val  Pro Ile 
    1325         


<210>  6824
<211>  1327
<212>  PRT
<213>  Homo Sapiens

<400>  6824

Met Thr Leu Asp Arg Pro Gly Glu Gly Ala Thr Met Leu Lys Thr Phe 
1               5                   10                  15      


Thr Val Leu Leu Phe Cys Ile Leu Met Asp Pro Gln Pro Glu Leu Trp 
            20                  25                  30          


Ile Glu Ser Asn Tyr Pro Gln Ala Pro Trp Glu Asn Ile Thr Leu Trp 
        35                  40                  45              


Cys Arg Ser Pro Ser Arg Ile Ser Ser Lys Phe Leu Leu Leu Lys Asp 
    50                  55                  60                  


Lys Thr Gln Met Thr Trp Ile Arg Pro Ser His Lys Thr Phe Gln Val 
65                  70                  75                  80  


Ser Phe Leu Ile Gly Ala Leu Thr Glu Ser Asn Ala Gly Leu Tyr Arg 
                85                  90                  95      


Cys Cys Tyr Trp Lys Glu Thr Gly Trp Ser Lys Pro Ser Lys Val Leu 
            100                 105                 110         


Glu Leu Glu Ala Pro Gly Gln Leu Pro Lys Pro Ile Phe Trp Ile Gln 
        115                 120                 125             


Ala Glu Thr Pro Ala Leu Pro Gly Cys Asn Val Asn Ile Leu Cys His 
    130                 135                 140                 


Gly Trp Leu Gln Asp Leu Val Phe Met Leu Phe Lys Glu Gly Tyr Ala 
145                 150                 155                 160 


Glu Pro Val Asp Tyr Gln Val Pro Thr Gly Thr Met Ala Ile Phe Ser 
                165                 170                 175     


Ile Asp Asn Leu Thr Pro Glu Asp Glu Gly Val Tyr Ile Cys Arg Thr 
            180                 185                 190         


His Ile Gln Met Leu Pro Thr Leu Trp Ser Glu Pro Ser Asn Pro Leu 
        195                 200                 205             


Lys Leu Val Val Ala Gly Leu Tyr Pro Lys Pro Thr Leu Thr Ala His 
    210                 215                 220                 


Pro Gly Pro Ile Met Ala Pro Gly Glu Ser Leu Asn Leu Arg Cys Gln 
225                 230                 235                 240 


Gly Pro Ile Tyr Gly Met Thr Phe Ala Leu Met Arg Val Glu Asp Leu 
                245                 250                 255     


Glu Lys Ser Phe Tyr His Lys Lys Thr Ile Lys Asn Glu Ala Asn Phe 
            260                 265                 270         


Phe Phe Gln Ser Leu Lys Ile Gln Asp Thr Gly His Tyr Leu Cys Phe 
        275                 280                 285             


Tyr Tyr Asp Ala Ser Tyr Arg Gly Ser Leu Leu Ser Asp Val Leu Lys 
    290                 295                 300                 


Ile Trp Val Thr Asp Thr Phe Pro Lys Thr Trp Leu Leu Ala Arg Pro 
305                 310                 315                 320 


Ser Ala Val Val Gln Met Gly Gln Asn Val Ser Leu Arg Cys Arg Gly 
                325                 330                 335     


Pro Val Asp Gly Val Gly Leu Ala Leu Tyr Lys Lys Gly Glu Asp Lys 
            340                 345                 350         


Pro Leu Gln Phe Leu Asp Ala Thr Ser Ile Asp Asp Asn Thr Ser Phe 
        355                 360                 365             


Phe Leu Asn Asn Val Thr Tyr Ser Asp Thr Gly Ile Tyr Ser Cys His 
    370                 375                 380                 


Tyr Leu Leu Thr Trp Lys Thr Ser Ile Arg Met Pro Ser His Asn Thr 
385                 390                 395                 400 


Val Glu Leu Met Val Val Asp Lys Pro Pro Lys Pro Ser Leu Ser Ala 
                405                 410                 415     


Trp Pro Ser Thr Val Phe Lys Leu Gly Lys Ala Ile Thr Leu Gln Cys 
            420                 425                 430         


Arg Val Ser His Pro Val Leu Glu Phe Ser Leu Glu Trp Glu Glu Arg 
        435                 440                 445             


Glu Thr Phe Gln Lys Phe Ser Val Asn Gly Asp Phe Ile Ile Ser Asn 
    450                 455                 460                 


Val Asp Gly Lys Gly Thr Gly Thr Tyr Ser Cys Ser Tyr Arg Val Glu 
465                 470                 475                 480 


Thr His Pro Asn Ile Trp Ser His Arg Ser Glu Pro Leu Lys Leu Met 
                485                 490                 495     


Gly Pro Ala Gly Tyr Leu Thr Trp Asn Tyr Val Leu Asn Glu Ala Ile 
            500                 505                 510         


Arg Leu Ser Leu Ile Met Gln Leu Val Ala Leu Leu Leu Val Val Leu 
        515                 520                 525             


Trp Ile Arg Trp Lys Cys Arg Arg Leu Arg Ile Arg Glu Ala Trp Leu 
    530                 535                 540                 


Leu Gly Thr Ala Gln Gly Val Thr Met Leu Phe Ile Val Thr Ala Leu 
545                 550                 555                 560 


Leu Cys Cys Gly Leu Cys Asn Gly Val Leu Ile Glu Glu Thr Glu Ile 
                565                 570                 575     


Val Met Pro Thr Pro Lys Pro Glu Leu Trp Ala Glu Thr Asn Phe Pro 
            580                 585                 590         


Leu Ala Pro Trp Lys Asn Leu Thr Leu Trp Cys Arg Ser Pro Ser Gly 
        595                 600                 605             


Ser Thr Lys Glu Phe Val Leu Leu Lys Asp Gly Thr Gly Trp Ile Ala 
    610                 615                 620                 


Thr Arg Pro Ala Ser Glu Gln Val Arg Ala Ala Phe Pro Leu Gly Ala 
625                 630                 635                 640 


Leu Thr Gln Ser His Thr Gly Ser Tyr His Cys His Ser Trp Glu Glu 
                645                 650                 655     


Met Ala Val Ser Glu Pro Ser Glu Ala Leu Glu Leu Val Gly Thr Asp 
            660                 665                 670         


Ile Leu Pro Lys Pro Val Ile Ser Ala Ser Pro Thr Ile Arg Gly Gln 
        675                 680                 685             


Glu Leu Gln Leu Arg Cys Lys Gly Trp Leu Ala Gly Met Gly Phe Ala 
    690                 695                 700                 


Leu Tyr Lys Glu Gly Glu Gln Glu Pro Val Gln Gln Leu Gly Ala Val 
705                 710                 715                 720 


Gly Arg Glu Ala Phe Phe Thr Ile Gln Arg Met Glu Asp Lys Asp Glu 
                725                 730                 735     


Gly Asn Tyr Ser Cys Arg Thr His Thr Glu Lys Arg Pro Phe Lys Trp 
            740                 745                 750         


Ser Glu Pro Ser Glu Pro Leu Glu Leu Val Ile Lys Glu Met Tyr Pro 
        755                 760                 765             


Lys Pro Phe Phe Lys Thr Trp Ala Ser Pro Val Val Thr Pro Gly Ala 
    770                 775                 780                 


Arg Val Thr Phe Asn Cys Ser Thr Pro His Gln His Met Ser Phe Ile 
785                 790                 795                 800 


Leu Tyr Lys Asp Gly Ser Glu Ile Ala Ser Ser Asp Arg Ser Trp Ala 
                805                 810                 815     


Ser Pro Gly Ala Ser Ala Ala His Phe Leu Ile Ile Ser Val Gly Ile 
            820                 825                 830         


Gly Asp Gly Gly Asn Tyr Ser Cys Arg Tyr Tyr Asp Phe Ser Ile Trp 
        835                 840                 845             


Ser Glu Pro Ser Asp Pro Val Glu Leu Val Val Thr Glu Phe Tyr Pro 
    850                 855                 860                 


Lys Pro Thr Leu Leu Ala Gln Pro Gly Pro Val Val Phe Pro Gly Lys 
865                 870                 875                 880 


Ser Val Ile Leu Arg Cys Gln Gly Thr Phe Gln Gly Met Arg Phe Ala 
                885                 890                 895     


Leu Leu Gln Glu Gly Ala His Val Pro Leu Gln Phe Arg Ser Val Ser 
            900                 905                 910         


Gly Asn Ser Ala Asp Phe Leu Leu His Thr Val Gly Ala Glu Asp Ser 
        915                 920                 925             


Gly Asn Tyr Ser Cys Ile Tyr Tyr Glu Thr Thr Met Ser Asn Arg Gly 
    930                 935                 940                 


Ser Tyr Leu Ser Met Pro Leu Met Ile Trp Val Thr Asp Thr Phe Pro 
945                 950                 955                 960 


Lys Pro Trp Leu Phe Ala Glu Pro Ser Ser Val Val Pro Met Gly Gln 
                965                 970                 975     


Asn Val Thr Leu Trp Cys Arg Gly Pro Val His Gly Val Gly Tyr Ile 
            980                 985                 990         


Leu His Lys Glu Gly Glu Ala Thr  Ser Met Gln Leu Trp  Gly Ser Thr 
        995                 1000                 1005             


Ser Asn  Asp Gly Ala Phe Pro  Ile Thr Asn Ile Ser  Gly Thr Ser 
    1010                 1015                 1020             


Met Gly  Arg Tyr Ser Cys Cys  Tyr His Pro Asp Trp  Thr Ser Ser 
    1025                 1030                 1035             


Ile Lys  Ile Gln Pro Ser Asn  Thr Leu Glu Leu Leu  Val Thr Gly 
    1040                 1045                 1050             


Leu Leu  Pro Lys Pro Ser Leu  Leu Ala Gln Pro Gly  Pro Met Val 
    1055                 1060                 1065             


Ala Pro  Gly Glu Asn Met Thr  Leu Gln Cys Gln Gly  Glu Leu Pro 
    1070                 1075                 1080             


Asp Ser  Thr Phe Val Leu Leu  Lys Glu Gly Ala Gln  Glu Pro Leu 
    1085                 1090                 1095             


Glu Gln  Gln Arg Pro Ser Gly  Tyr Arg Ala Asp Phe  Trp Met Pro 
    1100                 1105                 1110             


Ala Val  Arg Gly Glu Asp Ser  Gly Ile Tyr Ser Cys  Val Tyr Tyr 
    1115                 1120                 1125             


Leu Asp  Ser Thr Pro Phe Ala  Ala Ser Asn His Ser  Asp Ser Leu 
    1130                 1135                 1140             


Glu Ile  Trp Val Thr Asp Lys  Pro Pro Lys Pro Ser  Leu Ser Ala 
    1145                 1150                 1155             


Trp Pro  Ser Thr Met Phe Lys  Leu Gly Lys Asp Ile  Thr Leu Gln 
    1160                 1165                 1170             


Cys Arg  Gly Pro Leu Pro Gly  Val Glu Phe Val Leu  Glu His Asp 
    1175                 1180                 1185             


Gly Glu  Glu Ala Pro Gln Gln  Phe Ser Glu Asp Gly  Asp Phe Val 
    1190                 1195                 1200             


Ile Asn  Asn Val Glu Gly Lys  Gly Ile Gly Asn Tyr  Ser Cys Ser 
    1205                 1210                 1215             


Tyr Arg  Leu Gln Ala Tyr Pro  Asp Ile Trp Ser Glu  Pro Ser Asp 
    1220                 1225                 1230             


Pro Leu  Glu Leu Val Gly Ala  Ala Gly Pro Val Ala  Gln Glu Cys 
    1235                 1240                 1245             


Thr Val  Gly Asn Ile Val Arg  Ser Ser Leu Ile Val  Val Val Val 
    1250                 1255                 1260             


Val Ala  Leu Gly Val Val Leu  Ala Ile Glu Trp Lys  Lys Trp Pro 
    1265                 1270                 1275             


Arg Leu  Arg Thr Arg Gly Ser  Glu Thr Asp Gly Arg  Asp Gln Thr 
    1280                 1285                 1290             


Ile Ala  Leu Glu Glu Cys Asn  Gln Glu Gly Glu Pro  Gly Thr Pro 
    1295                 1300                 1305             


Ala Asn  Ser Pro Ser Ser Thr  Ser Gln Arg Ile Ser  Val Glu Leu 
    1310                 1315                 1320             


Pro Val  Pro Ile 
    1325         


<210>  6825
<211>  242
<212>  PRT
<213>  Homo Sapiens

<400>  6825

Met Thr Leu Asp Arg Pro Gly Glu Gly Ala Thr Met Leu Lys Thr Phe 
1               5                   10                  15      


Thr Val Leu Leu Phe Cys Ile Arg Met Ser Leu Gly Met Thr Ser Ile 
            20                  25                  30          


Val Met Asp Pro Gln Pro Glu Leu Trp Ile Glu Ser Asn Tyr Pro Gln 
        35                  40                  45              


Ala Pro Trp Glu Asn Ile Thr Leu Trp Cys Arg Ser Pro Ser Arg Ile 
    50                  55                  60                  


Ser Ser Lys Phe Leu Leu Leu Lys Asp Lys Thr Gln Met Thr Trp Ile 
65                  70                  75                  80  


Arg Pro Ser His Lys Thr Phe Gln Val Ser Phe Leu Ile Gly Ala Leu 
                85                  90                  95      


Thr Glu Ser Asn Ala Gly Leu Tyr Arg Cys Cys Tyr Trp Lys Glu Thr 
            100                 105                 110         


Gly Trp Ser Lys Pro Ser Lys Val Leu Glu Leu Glu Ala Pro Gly Gln 
        115                 120                 125             


Leu Pro Lys Pro Ile Phe Trp Ile Gln Ala Glu Thr Pro Ala Leu Pro 
    130                 135                 140                 


Gly Cys Asn Val Asn Ile Leu Cys His Gly Trp Leu Gln Asp Leu Val 
145                 150                 155                 160 


Phe Met Leu Phe Lys Glu Gly Tyr Ala Glu Pro Val Asp Tyr Gln Val 
                165                 170                 175     


Pro Thr Gly Thr Met Ala Ile Phe Ser Ile Asp Asn Leu Thr Pro Glu 
            180                 185                 190         


Asp Glu Gly Val Tyr Ile Cys Arg Thr His Ile Gln Met Leu Pro Thr 
        195                 200                 205             


Leu Trp Ser Glu Pro Ser Asn Pro Leu Lys Leu Val Val Ala Gly Gly 
    210                 215                 220                 


Cys Gly Tyr Gly Cys Trp His Leu Ala Ile Val Val Pro Gly Ile Met 
225                 230                 235                 240 


Ala Gly 
        


<210>  6826
<211>  242
<212>  PRT
<213>  Homo Sapiens

<400>  6826

Met Thr Leu Asp Arg Pro Gly Glu Gly Ala Thr Met Leu Lys Thr Phe 
1               5                   10                  15      


Thr Val Leu Leu Phe Cys Ile Arg Met Ser Leu Gly Met Thr Ser Ile 
            20                  25                  30          


Val Met Asp Pro Gln Pro Glu Leu Trp Ile Glu Ser Asn Tyr Pro Gln 
        35                  40                  45              


Ala Pro Trp Glu Asn Ile Thr Leu Trp Cys Arg Ser Pro Ser Arg Ile 
    50                  55                  60                  


Ser Ser Lys Phe Leu Leu Leu Lys Asp Lys Thr Gln Met Thr Trp Ile 
65                  70                  75                  80  


Arg Pro Ser His Lys Thr Phe Gln Val Ser Phe Leu Ile Gly Ala Leu 
                85                  90                  95      


Thr Glu Ser Asn Ala Gly Leu Tyr Arg Cys Cys Tyr Trp Lys Glu Thr 
            100                 105                 110         


Gly Trp Ser Lys Pro Ser Lys Val Leu Glu Leu Glu Ala Pro Gly Gln 
        115                 120                 125             


Leu Pro Lys Pro Ile Phe Trp Ile Gln Ala Glu Thr Pro Ala Leu Pro 
    130                 135                 140                 


Gly Cys Asn Val Asn Ile Leu Cys His Gly Trp Leu Gln Asp Leu Val 
145                 150                 155                 160 


Phe Met Leu Phe Lys Glu Gly Tyr Ala Glu Pro Val Asp Tyr Gln Val 
                165                 170                 175     


Pro Thr Gly Thr Met Ala Ile Phe Ser Ile Asp Asn Leu Thr Pro Glu 
            180                 185                 190         


Asp Glu Gly Val Tyr Ile Cys Arg Thr His Ile Gln Met Leu Pro Thr 
        195                 200                 205             


Leu Trp Ser Glu Pro Ser Asn Pro Leu Lys Leu Val Val Ala Gly Gly 
    210                 215                 220                 


Cys Gly Tyr Gly Cys Trp His Leu Ala Ile Val Val Pro Gly Ile Met 
225                 230                 235                 240 


Ala Gly 
        


<210>  6827
<211>  1341
<212>  PRT
<213>  Homo Sapiens

<400>  6827

Met Thr Leu Asp Arg Pro Gly Glu Gly Ala Thr Met Leu Lys Thr Phe 
1               5                   10                  15      


Thr Val Leu Leu Phe Cys Ile Arg Met Ser Leu Gly Met Thr Ser Ile 
            20                  25                  30          


Val Met Asp Pro Gln Pro Glu Leu Trp Ile Glu Ser Asn Tyr Pro Gln 
        35                  40                  45              


Ala Pro Trp Glu Asn Ile Thr Leu Trp Cys Arg Ser Pro Ser Arg Ile 
    50                  55                  60                  


Ser Ser Lys Phe Leu Leu Leu Lys Asp Lys Thr Gln Met Thr Trp Ile 
65                  70                  75                  80  


Arg Pro Ser His Lys Thr Phe Gln Val Ser Phe Leu Ile Gly Ala Leu 
                85                  90                  95      


Thr Glu Ser Asn Ala Gly Leu Tyr Arg Cys Cys Tyr Trp Lys Glu Thr 
            100                 105                 110         


Gly Trp Ser Lys Pro Ser Lys Val Leu Glu Leu Glu Ala Pro Gly Gln 
        115                 120                 125             


Leu Pro Lys Pro Ile Phe Trp Ile Gln Ala Glu Thr Pro Ala Leu Pro 
    130                 135                 140                 


Gly Cys Asn Val Asn Ile Leu Cys His Gly Trp Leu Gln Asp Leu Val 
145                 150                 155                 160 


Phe Met Leu Phe Lys Glu Gly Tyr Ala Glu Pro Val Asp Tyr Gln Val 
                165                 170                 175     


Pro Thr Gly Thr Met Ala Ile Phe Ser Ile Asp Asn Leu Thr Pro Glu 
            180                 185                 190         


Asp Glu Gly Val Tyr Ile Cys Arg Thr His Ile Gln Met Leu Pro Thr 
        195                 200                 205             


Leu Trp Ser Glu Pro Ser Asn Pro Leu Lys Leu Val Val Ala Gly Leu 
    210                 215                 220                 


Tyr Pro Lys Pro Thr Leu Thr Ala His Pro Gly Pro Ile Met Ala Pro 
225                 230                 235                 240 


Gly Glu Ser Leu Asn Leu Arg Cys Gln Gly Pro Ile Tyr Gly Met Thr 
                245                 250                 255     


Phe Ala Leu Met Arg Val Glu Asp Leu Glu Lys Ser Phe Tyr His Lys 
            260                 265                 270         


Lys Thr Ile Lys Asn Glu Ala Asn Phe Phe Phe Gln Ser Leu Lys Ile 
        275                 280                 285             


Gln Asp Thr Gly His Tyr Leu Cys Phe Tyr Tyr Asp Ala Ser Tyr Arg 
    290                 295                 300                 


Gly Ser Leu Leu Ser Asp Val Leu Lys Ile Trp Val Thr Asp Thr Phe 
305                 310                 315                 320 


Pro Lys Thr Trp Leu Leu Ala Arg Pro Ser Ala Val Val Gln Met Gly 
                325                 330                 335     


Gln Asn Val Ser Leu Arg Cys Arg Gly Pro Val Asp Gly Val Gly Leu 
            340                 345                 350         


Ala Leu Tyr Lys Lys Gly Glu Asp Lys Pro Leu Gln Phe Leu Asp Ala 
        355                 360                 365             


Thr Ser Ile Asp Asp Asn Thr Ser Phe Phe Leu Asn Asn Val Thr Tyr 
    370                 375                 380                 


Ser Asp Thr Gly Ile Tyr Ser Cys His Tyr Leu Leu Thr Trp Lys Thr 
385                 390                 395                 400 


Ser Ile Arg Met Pro Ser His Asn Thr Val Glu Leu Met Val Val Asp 
                405                 410                 415     


Lys Pro Pro Lys Pro Ser Leu Ser Ala Trp Pro Ser Thr Val Phe Lys 
            420                 425                 430         


Leu Gly Lys Ala Ile Thr Leu Gln Cys Arg Val Ser His Pro Val Leu 
        435                 440                 445             


Glu Phe Ser Leu Glu Trp Glu Glu Arg Glu Thr Phe Gln Lys Phe Ser 
    450                 455                 460                 


Val Asn Gly Asp Phe Ile Ile Ser Asn Val Asp Gly Lys Gly Thr Gly 
465                 470                 475                 480 


Thr Tyr Ser Cys Ser Tyr Arg Val Glu Thr His Pro Asn Ile Trp Ser 
                485                 490                 495     


His Arg Ser Glu Pro Leu Lys Leu Met Gly Pro Ala Gly Tyr Leu Thr 
            500                 505                 510         


Trp Asn Tyr Val Leu Asn Glu Ala Ile Arg Leu Ser Leu Ile Met Gln 
        515                 520                 525             


Leu Val Ala Leu Leu Leu Val Val Leu Trp Ile Arg Trp Lys Cys Arg 
    530                 535                 540                 


Arg Leu Arg Ile Arg Glu Ala Trp Leu Leu Gly Thr Ala Gln Gly Val 
545                 550                 555                 560 


Thr Met Leu Phe Ile Val Thr Ala Leu Leu Cys Cys Ala Ile Ser Phe 
                565                 570                 575     


Ala Gly Leu Cys Asn Gly Val Leu Ile Glu Glu Thr Glu Ile Val Met 
            580                 585                 590         


Pro Thr Pro Lys Pro Glu Leu Trp Ala Glu Thr Asn Phe Pro Leu Ala 
        595                 600                 605             


Pro Trp Lys Asn Leu Thr Leu Trp Cys Arg Ser Pro Ser Gly Ser Thr 
    610                 615                 620                 


Lys Glu Phe Val Leu Leu Lys Asp Gly Thr Gly Trp Ile Ala Thr Arg 
625                 630                 635                 640 


Pro Ala Ser Glu Gln Val Arg Ala Ala Phe Pro Leu Gly Ala Leu Thr 
                645                 650                 655     


Gln Ser His Thr Gly Ser Tyr His Cys His Ser Trp Glu Glu Met Ala 
            660                 665                 670         


Val Ser Glu Pro Ser Glu Ala Leu Glu Leu Val Gly Thr Asp Ile Leu 
        675                 680                 685             


Pro Lys Pro Val Ile Ser Ala Ser Pro Thr Ile Arg Gly Gln Glu Leu 
    690                 695                 700                 


Gln Leu Arg Cys Lys Gly Trp Leu Ala Gly Met Gly Phe Ala Leu Tyr 
705                 710                 715                 720 


Lys Glu Gly Glu Gln Glu Pro Val Gln Gln Leu Gly Ala Val Gly Arg 
                725                 730                 735     


Glu Ala Phe Phe Thr Ile Gln Arg Met Glu Asp Lys Asp Glu Gly Asn 
            740                 745                 750         


Tyr Ser Cys Arg Thr His Thr Glu Lys Arg Pro Phe Lys Trp Ser Glu 
        755                 760                 765             


Pro Ser Glu Pro Leu Glu Leu Val Ile Lys Glu Met Tyr Pro Lys Pro 
    770                 775                 780                 


Phe Phe Lys Thr Trp Ala Ser Pro Val Val Thr Pro Gly Ala Arg Val 
785                 790                 795                 800 


Thr Phe Asn Cys Ser Thr Pro His Gln His Met Ser Phe Ile Leu Tyr 
                805                 810                 815     


Lys Asp Gly Ser Glu Ile Ala Ser Ser Asp Arg Ser Trp Ala Ser Pro 
            820                 825                 830         


Gly Ala Ser Ala Ala His Phe Leu Ile Ile Ser Val Gly Ile Gly Asp 
        835                 840                 845             


Gly Gly Asn Tyr Ser Cys Arg Tyr Tyr Asp Phe Ser Ile Trp Ser Glu 
    850                 855                 860                 


Pro Ser Asp Pro Val Glu Leu Val Val Thr Glu Phe Tyr Pro Lys Pro 
865                 870                 875                 880 


Thr Leu Leu Ala Gln Pro Gly Pro Val Val Phe Pro Gly Lys Ser Val 
                885                 890                 895     


Ile Leu Arg Cys Gln Gly Thr Phe Gln Gly Met Arg Phe Ala Leu Leu 
            900                 905                 910         


Gln Glu Gly Ala His Val Pro Leu Gln Phe Arg Ser Val Ser Gly Asn 
        915                 920                 925             


Ser Ala Asp Phe Leu Leu His Thr Val Gly Ala Glu Asp Ser Gly Asn 
    930                 935                 940                 


Tyr Ser Cys Ile Tyr Tyr Glu Thr Thr Met Ser Asn Arg Gly Ser Tyr 
945                 950                 955                 960 


Leu Ser Met Pro Leu Met Ile Trp Val Thr Asp Thr Phe Pro Lys Pro 
                965                 970                 975     


Trp Leu Phe Ala Glu Pro Ser Ser Val Val Pro Met Gly Gln Asn Val 
            980                 985                 990         


Thr Leu Trp Cys Arg Gly Pro Val  His Gly Val Gly Tyr  Ile Leu His 
        995                 1000                 1005             


Lys Glu  Gly Glu Ala Thr Ser  Met Gln Leu Trp Gly  Ser Thr Ser 
    1010                 1015                 1020             


Asn Asp  Gly Ala Phe Pro Ile  Thr Asn Ile Ser Gly  Thr Ser Met 
    1025                 1030                 1035             


Gly Arg  Tyr Ser Cys Cys Tyr  His Pro Asp Trp Thr  Ser Ser Ile 
    1040                 1045                 1050             


Lys Ile  Gln Pro Ser Asn Thr  Leu Glu Leu Leu Val  Thr Gly Leu 
    1055                 1060                 1065             


Leu Pro  Lys Pro Ser Leu Leu  Ala Gln Pro Gly Pro  Met Val Ala 
    1070                 1075                 1080             


Pro Gly  Glu Asn Met Thr Leu  Gln Cys Gln Gly Glu  Leu Pro Asp 
    1085                 1090                 1095             


Ser Thr  Phe Val Leu Leu Lys  Glu Gly Ala Gln Glu  Pro Leu Glu 
    1100                 1105                 1110             


Gln Gln  Arg Pro Ser Gly Tyr  Arg Ala Asp Phe Trp  Met Pro Ala 
    1115                 1120                 1125             


Val Arg  Gly Glu Asp Ser Gly  Ile Tyr Ser Cys Val  Tyr Tyr Leu 
    1130                 1135                 1140             


Asp Ser  Thr Pro Phe Ala Ala  Ser Asn His Ser Asp  Ser Leu Glu 
    1145                 1150                 1155             


Ile Trp  Val Thr Asp Lys Pro  Pro Lys Pro Ser Leu  Ser Ala Trp 
    1160                 1165                 1170             


Pro Ser  Thr Met Phe Lys Leu  Gly Lys Asp Ile Thr  Leu Gln Cys 
    1175                 1180                 1185             


Arg Gly  Pro Leu Pro Gly Val  Glu Phe Val Leu Glu  His Asp Gly 
    1190                 1195                 1200             


Glu Glu  Ala Pro Gln Gln Phe  Ser Glu Asp Gly Asp  Phe Val Ile 
    1205                 1210                 1215             


Asn Asn  Val Glu Gly Lys Gly  Ile Gly Asn Tyr Ser  Cys Ser Tyr 
    1220                 1225                 1230             


Arg Leu  Gln Ala Tyr Pro Asp  Ile Trp Ser Glu Pro  Ser Asp Pro 
    1235                 1240                 1245             


Leu Glu  Leu Val Gly Ala Ala  Gly Pro Val Ala Gln  Glu Cys Thr 
    1250                 1255                 1260             


Val Gly  Asn Ile Val Arg Ser  Ser Leu Ile Val Val  Val Val Val 
    1265                 1270                 1275             


Ala Leu  Gly Val Val Leu Ala  Ile Glu Trp Lys Lys  Trp Pro Arg 
    1280                 1285                 1290             


Leu Arg  Thr Arg Gly Ser Glu  Thr Asp Gly Arg Asp  Gln Thr Ile 
    1295                 1300                 1305             


Ala Leu  Glu Glu Cys Asn Gln  Glu Gly Glu Pro Gly  Thr Pro Ala 
    1310                 1315                 1320             


Asn Ser  Pro Ser Ser Thr Ser  Gln Arg Ile Ser Val  Glu Leu Pro 
    1325                 1330                 1335             


Val Pro  Ile 
    1340     


<210>  6828
<211>  1336
<212>  PRT
<213>  Homo Sapiens

<400>  6828

Met Thr Leu Asp Arg Pro Gly Glu Gly Ala Thr Met Leu Lys Thr Phe 
1               5                   10                  15      


Thr Val Leu Leu Phe Cys Ile Arg Met Ser Leu Gly Met Thr Ser Ile 
            20                  25                  30          


Val Met Asp Pro Gln Pro Glu Leu Trp Ile Glu Ser Asn Tyr Pro Gln 
        35                  40                  45              


Ala Pro Trp Glu Asn Ile Thr Leu Trp Cys Arg Ser Pro Ser Arg Ile 
    50                  55                  60                  


Ser Ser Lys Phe Leu Leu Leu Lys Asp Lys Thr Gln Met Thr Trp Ile 
65                  70                  75                  80  


Arg Pro Ser His Lys Thr Phe Gln Val Ser Phe Leu Ile Gly Ala Leu 
                85                  90                  95      


Thr Glu Ser Asn Ala Gly Leu Tyr Arg Cys Cys Tyr Trp Lys Glu Thr 
            100                 105                 110         


Gly Trp Ser Lys Pro Ser Lys Val Leu Glu Leu Glu Ala Pro Gly Gln 
        115                 120                 125             


Leu Pro Lys Pro Ile Phe Trp Ile Gln Ala Glu Thr Pro Ala Leu Pro 
    130                 135                 140                 


Gly Cys Asn Val Asn Ile Leu Cys His Gly Trp Leu Gln Asp Leu Val 
145                 150                 155                 160 


Phe Met Leu Phe Lys Glu Gly Tyr Ala Glu Pro Val Asp Tyr Gln Val 
                165                 170                 175     


Pro Thr Gly Thr Met Ala Ile Phe Ser Ile Asp Asn Leu Thr Pro Glu 
            180                 185                 190         


Asp Glu Gly Val Tyr Ile Cys Arg Thr His Ile Gln Met Leu Pro Thr 
        195                 200                 205             


Leu Trp Ser Glu Pro Ser Asn Pro Leu Lys Leu Val Val Ala Gly Leu 
    210                 215                 220                 


Tyr Pro Lys Pro Thr Leu Thr Ala His Pro Gly Pro Ile Met Ala Pro 
225                 230                 235                 240 


Gly Glu Ser Leu Asn Leu Arg Cys Gln Gly Pro Ile Tyr Gly Met Thr 
                245                 250                 255     


Phe Ala Leu Met Arg Val Glu Asp Leu Glu Lys Ser Phe Tyr His Lys 
            260                 265                 270         


Lys Thr Ile Lys Asn Glu Ala Asn Phe Phe Phe Gln Ser Leu Lys Ile 
        275                 280                 285             


Gln Asp Thr Gly His Tyr Leu Cys Phe Tyr Tyr Asp Ala Ser Tyr Arg 
    290                 295                 300                 


Gly Ser Leu Leu Ser Asp Val Leu Lys Ile Trp Val Thr Asp Thr Phe 
305                 310                 315                 320 


Pro Lys Thr Trp Leu Leu Ala Arg Pro Ser Ala Val Val Gln Met Gly 
                325                 330                 335     


Gln Asn Val Ser Leu Arg Cys Arg Gly Pro Val Asp Gly Val Gly Leu 
            340                 345                 350         


Ala Leu Tyr Lys Lys Gly Glu Asp Lys Pro Leu Gln Phe Leu Asp Ala 
        355                 360                 365             


Thr Ser Ile Asp Asp Asn Thr Ser Phe Phe Leu Asn Asn Val Thr Tyr 
    370                 375                 380                 


Ser Asp Thr Gly Ile Tyr Ser Cys His Tyr Leu Leu Thr Trp Lys Thr 
385                 390                 395                 400 


Ser Ile Arg Met Pro Ser His Asn Thr Val Glu Leu Met Val Val Asp 
                405                 410                 415     


Lys Pro Pro Lys Pro Ser Leu Ser Ala Trp Pro Ser Thr Val Phe Lys 
            420                 425                 430         


Leu Gly Lys Ala Ile Thr Leu Gln Cys Arg Val Ser His Pro Val Leu 
        435                 440                 445             


Glu Phe Ser Leu Glu Trp Glu Glu Arg Glu Thr Phe Gln Lys Phe Ser 
    450                 455                 460                 


Val Asn Gly Asp Phe Ile Ile Ser Asn Val Asp Gly Lys Gly Thr Gly 
465                 470                 475                 480 


Thr Tyr Ser Cys Ser Tyr Arg Val Glu Thr His Pro Asn Ile Trp Ser 
                485                 490                 495     


His Arg Ser Glu Pro Leu Lys Leu Met Gly Pro Ala Gly Tyr Leu Thr 
            500                 505                 510         


Trp Asn Tyr Val Leu Asn Glu Ala Ile Arg Leu Ser Leu Ile Met Gln 
        515                 520                 525             


Leu Val Ala Leu Leu Leu Val Val Leu Trp Ile Arg Trp Lys Cys Arg 
    530                 535                 540                 


Arg Leu Arg Ile Arg Glu Ala Trp Leu Leu Gly Thr Ala Gln Gly Val 
545                 550                 555                 560 


Thr Met Leu Phe Ile Val Thr Ala Leu Leu Cys Cys Gly Leu Cys Asn 
                565                 570                 575     


Gly Val Leu Ile Glu Glu Thr Glu Ile Val Met Pro Thr Pro Lys Pro 
            580                 585                 590         


Glu Leu Trp Ala Glu Thr Asn Phe Pro Leu Ala Pro Trp Lys Asn Leu 
        595                 600                 605             


Thr Leu Trp Cys Arg Ser Pro Ser Gly Ser Thr Lys Glu Phe Val Leu 
    610                 615                 620                 


Leu Lys Asp Gly Thr Gly Trp Ile Ala Thr Arg Pro Ala Ser Glu Gln 
625                 630                 635                 640 


Val Arg Ala Ala Phe Pro Leu Gly Ala Leu Thr Gln Ser His Thr Gly 
                645                 650                 655     


Ser Tyr His Cys His Ser Trp Glu Glu Met Ala Val Ser Glu Pro Ser 
            660                 665                 670         


Glu Ala Leu Glu Leu Val Gly Thr Asp Ile Leu Pro Lys Pro Val Ile 
        675                 680                 685             


Ser Ala Ser Pro Thr Ile Arg Gly Gln Glu Leu Gln Leu Arg Cys Lys 
    690                 695                 700                 


Gly Trp Leu Ala Gly Met Gly Phe Ala Leu Tyr Lys Glu Gly Glu Gln 
705                 710                 715                 720 


Glu Pro Val Gln Gln Leu Gly Ala Val Gly Arg Glu Ala Phe Phe Thr 
                725                 730                 735     


Ile Gln Arg Met Glu Asp Lys Asp Glu Gly Asn Tyr Ser Cys Arg Thr 
            740                 745                 750         


His Thr Glu Lys Arg Pro Phe Lys Trp Ser Glu Pro Ser Glu Pro Leu 
        755                 760                 765             


Glu Leu Val Ile Lys Glu Met Tyr Pro Lys Pro Phe Phe Lys Thr Trp 
    770                 775                 780                 


Ala Ser Pro Val Val Thr Pro Gly Ala Arg Val Thr Phe Asn Cys Ser 
785                 790                 795                 800 


Thr Pro His Gln His Met Ser Phe Ile Leu Tyr Lys Asp Gly Ser Glu 
                805                 810                 815     


Ile Ala Ser Ser Asp Arg Ser Trp Ala Ser Pro Gly Ala Ser Ala Ala 
            820                 825                 830         


His Phe Leu Ile Ile Ser Val Gly Ile Gly Asp Gly Gly Asn Tyr Ser 
        835                 840                 845             


Cys Arg Tyr Tyr Asp Phe Ser Ile Trp Ser Glu Pro Ser Asp Pro Val 
    850                 855                 860                 


Glu Leu Val Val Thr Glu Phe Tyr Pro Lys Pro Thr Leu Leu Ala Gln 
865                 870                 875                 880 


Pro Gly Pro Val Val Phe Pro Gly Lys Ser Val Ile Leu Arg Cys Gln 
                885                 890                 895     


Gly Thr Phe Gln Gly Met Arg Phe Ala Leu Leu Gln Glu Gly Ala His 
            900                 905                 910         


Val Pro Leu Gln Phe Arg Ser Val Ser Gly Asn Ser Ala Asp Phe Leu 
        915                 920                 925             


Leu His Thr Val Gly Ala Glu Asp Ser Gly Asn Tyr Ser Cys Ile Tyr 
    930                 935                 940                 


Tyr Glu Thr Thr Met Ser Asn Arg Gly Ser Tyr Leu Ser Met Pro Leu 
945                 950                 955                 960 


Met Ile Trp Val Thr Asp Thr Phe Pro Lys Pro Trp Leu Phe Ala Glu 
                965                 970                 975     


Pro Ser Ser Val Val Pro Met Gly Gln Asn Val Thr Leu Trp Cys Arg 
            980                 985                 990         


Gly Pro Val His Gly Val Gly Tyr  Ile Leu His Lys Glu  Gly Glu Ala 
        995                 1000                 1005             


Thr Ser  Met Gln Leu Trp Gly  Ser Thr Ser Asn Asp  Gly Ala Phe 
    1010                 1015                 1020             


Pro Ile  Thr Asn Ile Ser Gly  Thr Ser Met Gly Arg  Tyr Ser Cys 
    1025                 1030                 1035             


Cys Tyr  His Pro Asp Trp Thr  Ser Ser Ile Lys Ile  Gln Pro Ser 
    1040                 1045                 1050             


Asn Thr  Leu Glu Leu Leu Val  Thr Gly Leu Leu Pro  Lys Pro Ser 
    1055                 1060                 1065             


Leu Leu  Ala Gln Pro Gly Pro  Met Val Ala Pro Gly  Glu Asn Met 
    1070                 1075                 1080             


Thr Leu  Gln Cys Gln Gly Glu  Leu Pro Asp Ser Thr  Phe Val Leu 
    1085                 1090                 1095             


Leu Lys  Glu Gly Ala Gln Glu  Pro Leu Glu Gln Gln  Arg Pro Ser 
    1100                 1105                 1110             


Gly Tyr  Arg Ala Asp Phe Trp  Met Pro Ala Val Arg  Gly Glu Asp 
    1115                 1120                 1125             


Ser Gly  Ile Tyr Ser Cys Val  Tyr Tyr Leu Asp Ser  Thr Pro Phe 
    1130                 1135                 1140             


Ala Ala  Ser Asn His Ser Asp  Ser Leu Glu Ile Trp  Val Thr Asp 
    1145                 1150                 1155             


Lys Pro  Pro Lys Pro Ser Leu  Ser Ala Trp Pro Ser  Thr Met Phe 
    1160                 1165                 1170             


Lys Leu  Gly Lys Asp Ile Thr  Leu Gln Cys Arg Gly  Pro Leu Pro 
    1175                 1180                 1185             


Gly Val  Glu Phe Val Leu Glu  His Asp Gly Glu Glu  Ala Pro Gln 
    1190                 1195                 1200             


Gln Phe  Ser Glu Asp Gly Asp  Phe Val Ile Asn Asn  Val Glu Gly 
    1205                 1210                 1215             


Lys Gly  Ile Gly Asn Tyr Ser  Cys Ser Tyr Arg Leu  Gln Ala Tyr 
    1220                 1225                 1230             


Pro Asp  Ile Trp Ser Glu Pro  Ser Asp Pro Leu Glu  Leu Val Gly 
    1235                 1240                 1245             


Ala Ala  Gly Pro Val Ala Gln  Glu Cys Thr Val Gly  Asn Ile Val 
    1250                 1255                 1260             


Arg Ser  Ser Leu Ile Val Val  Val Val Val Ala Leu  Gly Val Val 
    1265                 1270                 1275             


Leu Ala  Ile Glu Trp Lys Lys  Trp Pro Arg Leu Arg  Thr Arg Gly 
    1280                 1285                 1290             


Ser Glu  Thr Asp Gly Arg Asp  Gln Thr Ile Ala Leu  Glu Glu Cys 
    1295                 1300                 1305             


Asn Gln  Glu Gly Glu Pro Gly  Thr Pro Ala Asn Ser  Pro Ser Ser 
    1310                 1315                 1320             


Thr Ser  Gln Arg Ile Ser Val  Glu Leu Pro Val Pro  Ile 
    1325                 1330                 1335     


<210>  6829
<211>  2623
<212>  PRT
<213>  Homo Sapiens

<400>  6829

Met Lys Val Lys Gly Arg Gly Ile Thr Cys Leu Leu Val Ser Phe Ala 
1               5                   10                  15      


Val Ile Cys Leu Val Ala Thr Pro Gly Gly Lys Ala Cys Pro Arg Arg 
            20                  25                  30          


Cys Ala Cys Tyr Met Pro Thr Glu Val His Cys Thr Phe Arg Tyr Leu 
        35                  40                  45              


Thr Ser Ile Pro Asp Ser Ile Pro Pro Asn Val Glu Arg Ile Asn Leu 
    50                  55                  60                  


Gly Tyr Asn Ser Leu Val Arg Leu Met Glu Thr Asp Phe Ser Gly Leu 
65                  70                  75                  80  


Thr Lys Leu Glu Leu Leu Met Leu His Ser Asn Gly Ile His Thr Ile 
                85                  90                  95      


Pro Asp Lys Thr Phe Ser Asp Leu Gln Ala Leu Gln Val Leu Lys Met 
            100                 105                 110         


Ser Tyr Asn Lys Val Arg Lys Leu Gln Lys Asp Thr Phe Tyr Gly Leu 
        115                 120                 125             


Arg Ser Leu Thr Arg Leu His Met Asp His Asn Asn Ile Glu Phe Ile 
    130                 135                 140                 


Asn Pro Glu Val Phe Tyr Gly Leu Asn Phe Leu Arg Leu Val His Leu 
145                 150                 155                 160 


Glu Gly Asn Gln Leu Thr Lys Leu His Pro Asp Thr Phe Val Ser Leu 
                165                 170                 175     


Ser Tyr Leu Gln Ile Phe Lys Ile Ser Phe Ile Lys Phe Leu Tyr Leu 
            180                 185                 190         


Ser Asp Asn Phe Leu Thr Ser Leu Pro Gln Glu Met Val Ser Tyr Met 
        195                 200                 205             


Pro Asp Leu Asp Ser Leu Tyr Leu His Gly Asn Pro Trp Thr Cys Asp 
    210                 215                 220                 


Cys His Leu Lys Trp Leu Ser Asp Trp Ile Gln Glu Lys Pro Asp Val 
225                 230                 235                 240 


Ile Lys Cys Lys Lys Asp Arg Ser Pro Ser Ser Ala Gln Gln Cys Pro 
                245                 250                 255     


Leu Cys Met Asn Pro Arg Thr Ser Lys Gly Lys Pro Leu Ala Met Val 
            260                 265                 270         


Ser Ala Ala Ala Phe Gln Cys Ala Lys Pro Thr Ile Asp Ser Ser Leu 
        275                 280                 285             


Lys Ser Lys Ser Leu Thr Ile Leu Glu Asp Ser Ser Ser Ala Phe Ile 
    290                 295                 300                 


Ser Pro Gln Gly Phe Met Ala Pro Phe Gly Ser Leu Thr Leu Asn Met 
305                 310                 315                 320 


Thr Asp Gln Ser Gly Asn Glu Ala Asn Met Val Cys Ser Ile Gln Lys 
                325                 330                 335     


Pro Ser Arg Thr Ser Pro Ile Ala Phe Thr Glu Glu Asn Asp Tyr Ile 
            340                 345                 350         


Val Leu Asn Thr Ser Phe Ser Thr Phe Leu Val Cys Asn Ile Asp Tyr 
        355                 360                 365             


Gly His Ile Gln Pro Val Trp Gln Ile Leu Ala Leu Tyr Ser Asp Ser 
    370                 375                 380                 


Pro Leu Ile Leu Glu Arg Ser His Leu Leu Ser Glu Thr Pro Gln Leu 
385                 390                 395                 400 


Tyr Tyr Lys Tyr Lys Gln Val Ala Pro Lys Pro Glu Asp Ile Phe Thr 
                405                 410                 415     


Asn Ile Glu Ala Asp Leu Arg Ala Asp Pro Ser Trp Leu Met Gln Asp 
            420                 425                 430         


Gln Ile Ser Leu Gln Leu Asn Arg Thr Ala Thr Thr Phe Ser Thr Leu 
        435                 440                 445             


Gln Ile Gln Tyr Ser Ser Asp Ala Gln Ile Thr Leu Pro Arg Ala Glu 
    450                 455                 460                 


Met Arg Pro Val Lys His Lys Trp Thr Met Ile Ser Arg Asp Asn Asn 
465                 470                 475                 480 


Thr Lys Leu Glu His Thr Val Leu Val Gly Gly Thr Val Gly Leu Asn 
                485                 490                 495     


Cys Pro Gly Gln Gly Asp Pro Thr Pro His Val Asp Trp Leu Leu Ala 
            500                 505                 510         


Asp Gly Ser Lys Val Arg Ala Pro Tyr Val Ser Glu Asp Gly Arg Ile 
        515                 520                 525             


Leu Ile Asp Lys Ser Gly Lys Leu Glu Leu Gln Met Ala Asp Ser Phe 
    530                 535                 540                 


Asp Thr Gly Val Tyr His Cys Ile Ser Ser Asn Tyr Asp Asp Ala Asp 
545                 550                 555                 560 


Ile Leu Thr Tyr Arg Ile Thr Val Val Glu Pro Leu Val Glu Ala Tyr 
                565                 570                 575     


Gln Glu Asn Gly Ile His His Thr Val Phe Ile Gly Glu Thr Leu Asp 
            580                 585                 590         


Leu Pro Cys His Ser Thr Gly Ile Pro Asp Ala Ser Ile Ser Trp Val 
        595                 600                 605             


Ile Pro Gly Asn Asn Val Leu Tyr Gln Ser Ser Arg Asp Lys Lys Val 
    610                 615                 620                 


Leu Asn Asn Gly Thr Leu Arg Ile Leu Gln Val Thr Pro Lys Asp Gln 
625                 630                 635                 640 


Gly Tyr Tyr Arg Cys Val Ala Ala Asn Pro Ser Gly Val Asp Phe Leu 
                645                 650                 655     


Ile Phe Gln Val Ser Val Lys Met Lys Gly Gln Arg Pro Leu Glu His 
            660                 665                 670         


Asp Gly Glu Thr Glu Gly Ser Gly Leu Asp Glu Ser Asn Pro Ile Ala 
        675                 680                 685             


His Leu Lys Glu Pro Pro Gly Ala Gln Leu Arg Thr Ser Ala Leu Met 
    690                 695                 700                 


Glu Ala Glu Val Gly Lys His Thr Ser Ser Thr Ser Lys Arg His Asn 
705                 710                 715                 720 


Tyr Arg Glu Leu Thr Leu Gln Arg Arg Gly Asp Ser Thr His Arg Arg 
                725                 730                 735     


Phe Arg Glu Asn Arg Arg His Phe Pro Pro Ser Ala Arg Arg Ile Asp 
            740                 745                 750         


Pro Gln His Trp Ala Ala Leu Leu Glu Lys Ala Lys Lys Asn Ala Met 
        755                 760                 765             


Pro Asp Lys Arg Glu Asn Thr Thr Val Ser Pro Pro Pro Val Val Thr 
    770                 775                 780                 


Gln Leu Pro Asn Ile Pro Gly Glu Glu Asp Asp Ser Ser Gly Met Leu 
785                 790                 795                 800 


Ala Leu His Glu Glu Phe Met Val Pro Ala Thr Lys Ala Leu Asn Leu 
                805                 810                 815     


Pro Ala Arg Thr Val Thr Ala Asp Ser Arg Thr Ile Ser Asp Ser Pro 
            820                 825                 830         


Met Thr Asn Ile Asn Tyr Gly Thr Glu Phe Ser Pro Val Val Asn Ser 
        835                 840                 845             


Gln Ile Leu Pro Pro Glu Glu Pro Thr Asp Phe Lys Leu Ser Thr Ala 
    850                 855                 860                 


Ile Lys Thr Thr Ala Met Ser Lys Asn Ile Asn Pro Thr Met Ser Ser 
865                 870                 875                 880 


Gln Ile Gln Gly Thr Thr Asn Gln His Ser Ser Thr Val Phe Pro Leu 
                885                 890                 895     


Leu Leu Gly Ala Thr Glu Phe Gln Asp Ser Asp Gln Met Gly Arg Gly 
            900                 905                 910         


Arg Glu His Phe Gln Ser Arg Pro Pro Ile Thr Val Arg Thr Met Ile 
        915                 920                 925             


Lys Asp Val Asn Val Lys Met Leu Ser Ser Thr Thr Asn Lys Leu Leu 
    930                 935                 940                 


Leu Glu Ser Val Asn Thr Thr Asn Ser His Gln Thr Ser Val Arg Glu 
945                 950                 955                 960 


Val Ser Glu Pro Arg His Asn His Phe Tyr Ser His Thr Thr Gln Ile 
                965                 970                 975     


Leu Ser Thr Ser Thr Phe Pro Ser Asp Pro His Thr Ala Ala His Ser 
            980                 985                 990         


Gln Phe Pro Ile Pro Arg Asn Ser  Thr Val Asn Ile Pro  Leu Phe Arg 
        995                 1000                 1005             


Arg Phe  Gly Arg Gln Arg Lys  Ile Gly Gly Arg Gly  Arg Ile Ile 
    1010                 1015                 1020             


Ser Pro  Tyr Arg Thr Pro Val  Leu Arg Arg His Arg  Tyr Ser Ile 
    1025                 1030                 1035             


Phe Arg  Ser Thr Thr Arg Gly  Ser Ser Glu Lys Ser  Thr Thr Ala 
    1040                 1045                 1050             


Phe Ser  Ala Thr Val Leu Asn  Val Thr Cys Leu Ser  Cys Leu Pro 
    1055                 1060                 1065             


Arg Glu  Arg Leu Thr Thr Ala  Thr Ala Ala Leu Ser  Phe Pro Ser 
    1070                 1075                 1080             


Ala Ala  Pro Ile Thr Phe Pro  Lys Ala Asp Ile Ala  Arg Val Pro 
    1085                 1090                 1095             


Ser Glu  Glu Ser Thr Thr Leu  Val Gln Asn Pro Leu  Leu Leu Leu 
    1100                 1105                 1110             


Glu Asn  Lys Pro Ser Val Glu  Lys Thr Thr Pro Thr  Ile Lys Tyr 
    1115                 1120                 1125             


Phe Arg  Thr Glu Ile Ser Gln  Val Thr Pro Thr Gly  Ala Val Met 
    1130                 1135                 1140             


Thr Tyr  Ala Pro Thr Ser Ile  Pro Met Glu Lys Thr  His Lys Val 
    1145                 1150                 1155             


Asn Ala  Ser Tyr Pro Arg Val  Ser Ser Thr Asn Glu  Ala Lys Arg 
    1160                 1165                 1170             


Asp Ser  Val Ile Thr Ser Ser  Leu Ser Gly Ala Ile  Thr Lys Pro 
    1175                 1180                 1185             


Pro Met  Thr Ile Ile Ala Ile  Thr Arg Phe Ser Arg  Arg Lys Ile 
    1190                 1195                 1200             


Pro Trp  Gln Gln Asn Phe Val  Asn Asn His Asn Pro  Lys Gly Arg 
    1205                 1210                 1215             


Leu Arg  Asn Gln His Lys Val  Ser Leu Gln Lys Ser  Thr Ala Val 
    1220                 1225                 1230             


Met Leu  Pro Lys Thr Ser Pro  Ala Leu Pro Arg Asp  Lys Val Ser 
    1235                 1240                 1245             


Pro Phe  His Phe Thr Thr Leu  Ser Thr Ser Val Met  Gln Ile Pro 
    1250                 1255                 1260             


Ser Asn  Thr Leu Thr Thr Ala  His His Thr Thr Thr  Lys Thr His 
    1265                 1270                 1275             


Asn Pro  Gly Ser Leu Pro Thr  Lys Lys Glu Leu Pro  Phe Pro Pro 
    1280                 1285                 1290             


Leu Asn  Pro Met Leu Pro Ser  Ile Ile Ser Lys Asp  Ser Ser Thr 
    1295                 1300                 1305             


Lys Ser  Ile Ile Ser Thr Gln  Thr Ala Ile Pro Ala  Thr Thr Pro 
    1310                 1315                 1320             


Thr Phe  Pro Ala Ser Val Ile  Thr Tyr Glu Thr Gln  Thr Glu Arg 
    1325                 1330                 1335             


Ser Arg  Ala Gln Thr Ile Gln  Arg Glu Gln Glu Pro  Gln Lys Lys 
    1340                 1345                 1350             


Asn Arg  Thr Asp Pro Asn Ile  Ser Pro Asp Gln Ser  Ser Gly Phe 
    1355                 1360                 1365             


Thr Thr  Pro Thr Ala Met Thr  Pro Pro Val Leu Thr  Thr Ala Glu 
    1370                 1375                 1380             


Thr Ser  Val Lys Pro Ser Val  Ser Ala Phe Thr His  Ser Pro Pro 
    1385                 1390                 1395             


Glu Asn  Thr Thr Gly Ile Ser  Ser Thr Ile Ser Phe  His Ser Arg 
    1400                 1405                 1410             


Thr Leu  Asn Leu Thr Asp Val  Ile Glu Glu Leu Ala  Gln Ala Ser 
    1415                 1420                 1425             


Thr Gln  Thr Leu Lys Ser Thr  Ile Ala Ser Glu Thr  Thr Leu Ser 
    1430                 1435                 1440             


Ser Lys  Ser His Gln Ser Thr  Thr Thr Arg Lys Ala  Ile Ile Arg 
    1445                 1450                 1455             


His Ser  Thr Ile Pro Pro Phe  Leu Ser Ser Ser Ala  Thr Leu Met 
    1460                 1465                 1470             


Pro Val  Pro Ile Ser Pro Pro  Phe Thr Gln Arg Ala  Val Thr Asp 
    1475                 1480                 1485             


Asn Val  Ala Thr Pro Ile Ser  Gly Leu Met Thr Asn  Thr Val Val 
    1490                 1495                 1500             


Lys Leu  His Glu Ser Ser Arg  His Asn Ala Lys Pro  Gln Gln Leu 
    1505                 1510                 1515             


Val Ala  Glu Val Ala Thr Ser  Pro Lys Val His Pro  Asn Ala Lys 
    1520                 1525                 1530             


Phe Thr  Ile Gly Thr Thr His  Phe Ile Tyr Ser Asn  Leu Leu His 
    1535                 1540                 1545             


Ser Thr  Pro Met Pro Ala Leu  Thr Thr Val Lys Ser  Gln Asn Ser 
    1550                 1555                 1560             


Lys Leu  Thr Pro Ser Pro Trp  Ala Glu Asn Gln Phe  Trp His Lys 
    1565                 1570                 1575             


Pro Tyr  Ser Glu Ile Ala Glu  Lys Gly Lys Lys Pro  Glu Val Ser 
    1580                 1585                 1590             


Met Leu  Ala Thr Thr Gly Leu  Ser Glu Ala Thr Thr  Leu Val Ser 
    1595                 1600                 1605             


Asp Trp  Asp Gly Gln Lys Asn  Thr Lys Lys Ser Asp  Phe Asp Lys 
    1610                 1615                 1620             


Lys Pro  Val Gln Glu Ala Thr  Thr Ser Lys Leu Leu  Pro Phe Asp 
    1625                 1630                 1635             


Ser Leu  Ser Arg Tyr Ile Phe  Glu Lys Pro Arg Ile  Val Gly Gly 
    1640                 1645                 1650             


Lys Ala  Ala Ser Phe Thr Ile  Pro Ala Asn Ser Asp  Ala Phe Leu 
    1655                 1660                 1665             


Pro Cys  Glu Ala Val Gly Asn  Pro Leu Pro Thr Ile  His Trp Thr 
    1670                 1675                 1680             


Arg Val  Pro Ser Gly Leu Asp  Leu Ser Lys Arg Lys  Gln Asn Ser 
    1685                 1690                 1695             


Arg Val  Gln Val Leu Pro Asn  Gly Thr Leu Ser Ile  Gln Arg Val 
    1700                 1705                 1710             


Glu Ile  Gln Asp Arg Gly Gln  Tyr Leu Cys Ser Ala  Ser Asn Leu 
    1715                 1720                 1725             


Phe Gly  Thr Asp His Leu His  Val Thr Leu Ser Val  Val Ser Tyr 
    1730                 1735                 1740             


Pro Pro  Arg Ile Leu Glu Arg  Arg Thr Lys Glu Ile  Thr Val His 
    1745                 1750                 1755             


Ser Gly  Ser Thr Val Glu Leu  Lys Cys Arg Ala Glu  Gly Arg Pro 
    1760                 1765                 1770             


Ser Pro  Thr Val Thr Trp Ile  Leu Ala Asn Gln Thr  Val Val Ser 
    1775                 1780                 1785             


Glu Ser  Ser Gln Gly Ser Arg  Gln Ala Val Val Thr  Val Asp Gly 
    1790                 1795                 1800             


Thr Leu  Val Leu His Asn Leu  Ser Ile Tyr Asp Arg  Gly Phe Tyr 
    1805                 1810                 1815             


Lys Cys  Val Ala Ser Asn Pro  Gly Gly Gln Asp Ser  Leu Leu Val 
    1820                 1825                 1830             


Lys Ile  Gln Val Ile Ala Ala  Pro Pro Val Ile Leu  Glu Gln Arg 
    1835                 1840                 1845             


Arg Gln  Val Ile Val Gly Thr  Trp Gly Glu Ser Leu  Lys Leu Pro 
    1850                 1855                 1860             


Cys Thr  Ala Lys Gly Thr Pro  Gln Pro Ser Val Tyr  Trp Val Leu 
    1865                 1870                 1875             


Ser Asp  Gly Thr Glu Val Lys  Pro Leu Gln Phe Thr  Asn Ser Lys 
    1880                 1885                 1890             


Leu Phe  Leu Phe Ser Asn Gly  Thr Leu Tyr Ile Arg  Asn Leu Ala 
    1895                 1900                 1905             


Ser Ser  Asp Arg Gly Thr Tyr  Glu Cys Ile Ala Thr  Ser Ser Thr 
    1910                 1915                 1920             


Gly Ser  Glu Arg Arg Val Val  Met Leu Thr Met Glu  Glu Arg Val 
    1925                 1930                 1935             


Thr Ser  Pro Arg Ile Glu Ala  Ala Ser Gln Lys Arg  Thr Glu Val 
    1940                 1945                 1950             


Asn Phe  Gly Asp Lys Leu Leu  Leu Asn Cys Ser Ala  Thr Gly Glu 
    1955                 1960                 1965             


Pro Lys  Pro Gln Ile Met Trp  Arg Leu Pro Ser Lys  Ala Val Val 
    1970                 1975                 1980             


Asp Gln  Gln His Arg Val Gly  Ser Trp Ile His Val  Tyr Pro Asn 
    1985                 1990                 1995             


Gly Ser  Leu Phe Ile Gly Ser  Val Thr Glu Lys Asp  Ser Gly Val 
    2000                 2005                 2010             


Tyr Leu  Cys Val Ala Arg Asn  Lys Met Gly Asp Asp  Leu Ile Leu 
    2015                 2020                 2025             


Met His  Val Ser Leu Arg Leu  Lys Pro Ala Lys Ile  Asp His Lys 
    2030                 2035                 2040             


Gln Tyr  Phe Arg Lys Gln Val  Leu His Gly Lys Asp  Phe Gln Val 
    2045                 2050                 2055             


Asp Cys  Lys Ala Ser Gly Ser  Pro Val Pro Glu Ile  Ser Trp Ser 
    2060                 2065                 2070             


Leu Pro  Asp Gly Thr Met Ile  Asn Asn Ala Met Gln  Ala Asp Asp 
    2075                 2080                 2085             


Ser Gly  His Arg Thr Arg Arg  Tyr Thr Leu Phe Asn  Asn Gly Thr 
    2090                 2095                 2100             


Leu Tyr  Phe Asn Lys Val Gly  Val Ala Glu Glu Gly  Asp Tyr Thr 
    2105                 2110                 2115             


Cys Tyr  Ala Gln Asn Thr Leu  Gly Lys Asp Glu Met  Lys Val His 
    2120                 2125                 2130             


Leu Thr  Val Ile Thr Ala Ala  Pro Arg Ile Arg Gln  Ser Asn Lys 
    2135                 2140                 2145             


Thr Asn  Lys Arg Ile Lys Ala  Gly Asp Thr Ala Val  Leu Asp Cys 
    2150                 2155                 2160             


Glu Val  Thr Gly Asp Pro Lys  Pro Lys Ile Phe Trp  Leu Leu Pro 
    2165                 2170                 2175             


Ser Asn  Asp Met Ile Ser Phe  Ser Ile Asp Arg Tyr  Thr Phe His 
    2180                 2185                 2190             


Ala Asn  Gly Ser Leu Thr Ile  Asn Lys Val Lys Leu  Leu Asp Ser 
    2195                 2200                 2205             


Gly Glu  Tyr Val Cys Val Ala  Arg Asn Pro Ser Gly  Asp Asp Thr 
    2210                 2215                 2220             


Lys Met  Tyr Lys Leu Asp Val  Val Ser Lys Pro Pro  Leu Ile Asn 
    2225                 2230                 2235             


Gly Leu  Tyr Thr Asn Arg Thr  Val Ile Lys Ala Thr  Ala Val Arg 
    2240                 2245                 2250             


His Ser  Lys Lys His Phe Asp  Cys Arg Ala Glu Gly  Thr Pro Ser 
    2255                 2260                 2265             


Pro Glu  Val Met Trp Ile Met  Pro Asp Asn Ile Phe  Leu Thr Ala 
    2270                 2275                 2280             


Pro Tyr  Tyr Gly Ser Arg Ile  Thr Val His Lys Asn  Gly Thr Leu 
    2285                 2290                 2295             


Glu Ile  Arg Asn Val Arg Leu  Ser Asp Ser Ala Asp  Phe Ile Cys 
    2300                 2305                 2310             


Val Ala  Arg Asn Glu Gly Gly  Glu Ser Val Leu Val  Val Gln Leu 
    2315                 2320                 2325             


Glu Val  Leu Glu Met Leu Arg  Arg Pro Thr Phe Arg  Asn Pro Phe 
    2330                 2335                 2340             


Asn Glu  Lys Ile Val Ala Gln  Leu Gly Lys Ser Thr  Ala Leu Asn 
    2345                 2350                 2355             


Cys Ser  Val Asp Gly Asn Pro  Pro Pro Glu Ile Ile  Trp Ile Leu 
    2360                 2365                 2370             


Pro Asn  Gly Thr Arg Phe Ser  Asn Gly Pro Gln Ser  Tyr Gln Tyr 
    2375                 2380                 2385             


Leu Ile  Ala Ser Asn Gly Ser  Phe Ile Ile Ser Lys  Thr Thr Arg 
    2390                 2395                 2400             


Glu Asp  Ala Gly Lys Tyr Arg  Cys Ala Ala Arg Asn  Lys Val Gly 
    2405                 2410                 2415             


Tyr Ile  Glu Lys Leu Val Ile  Leu Glu Ile Gly Gln  Lys Pro Val 
    2420                 2425                 2430             


Ile Leu  Thr Tyr Ala Pro Gly  Thr Val Lys Gly Ile  Ser Gly Glu 
    2435                 2440                 2445             


Ser Leu  Ser Leu His Cys Val  Ser Asp Gly Ile Pro  Lys Pro Asn 
    2450                 2455                 2460             


Ile Lys  Trp Thr Met Pro Ser  Gly Tyr Val Val Asp  Arg Pro Gln 
    2465                 2470                 2475             


Ile Asn  Gly Lys Tyr Ile Leu  His Asp Asn Gly Thr  Leu Val Ile 
    2480                 2485                 2490             


Lys Glu  Ala Thr Ala Tyr Asp  Arg Gly Asn Tyr Ile  Cys Lys Ala 
    2495                 2500                 2505             


Gln Asn  Ser Val Gly His Thr  Leu Ile Thr Val Pro  Val Met Ile 
    2510                 2515                 2520             


Val Ala  Tyr Pro Pro Arg Ile  Thr Asn Arg Pro Pro  Arg Ser Ile 
    2525                 2530                 2535             


Val Thr  Arg Thr Gly Ala Ala  Phe Gln Leu His Cys  Val Ala Leu 
    2540                 2545                 2550             


Gly Val  Pro Lys Pro Glu Ile  Thr Trp Glu Met Pro  Asp His Ser 
    2555                 2560                 2565             


Leu Leu  Ser Thr Ala Ser Lys  Glu Arg Thr His Gly  Ser Glu Gln 
    2570                 2575                 2580             


Leu His  Leu Gln Gly Thr Leu  Val Ile Gln Asn Pro  Gln Thr Ser 
    2585                 2590                 2595             


Asp Ser  Gly Ile Tyr Lys Cys  Thr Ala Lys Asn Pro  Leu Gly Ser 
    2600                 2605                 2610             


Asp Tyr  Ala Ala Thr Tyr Ile  Gln Val Ile 
    2615                 2620             


<210>  6830
<211>  86
<212>  PRT
<213>  Homo Sapiens

<400>  6830

Thr Met Glu Glu Arg Val Thr Ser Pro Arg Ile Glu Ala Ala Ser Gln 
1               5                   10                  15      


Lys Arg Thr Glu Val Asn Phe Gly Asp Lys Leu Leu Leu Asn Cys Ser 
            20                  25                  30          


Ala Thr Gly Glu Pro Lys Pro Gln Ile Met Trp Arg Leu Pro Ser Lys 
        35                  40                  45              


Ala Val Val Asp Gln Gln His Arg Ile Leu Asp Phe Tyr Phe Ser Glu 
    50                  55                  60                  


Ala Glu Ala Met Pro Cys Ser Cys Cys Asn His Lys Thr Glu Tyr Pro 
65                  70                  75                  80  


Ala Tyr Tyr Cys Gln Val 
                85      


<210>  6831
<211>  406
<212>  PRT
<213>  Homo Sapiens

<400>  6831

Met Ser Leu Val Glu Leu Leu Leu Trp Trp Asn Cys Phe Ser Arg Thr 
1               5                   10                  15      


Gly Val Ala Ala Ser Leu Glu Val Ser Glu Ser Pro Gly Ser Ile Gln 
            20                  25                  30          


Val Ala Arg Gly Gln Pro Ala Val Leu Pro Cys Thr Phe Thr Thr Ser 
        35                  40                  45              


Ala Ala Leu Ile Asn Leu Asn Val Ile Trp Met Val Thr Pro Leu Ser 
    50                  55                  60                  


Asn Ala Asn Gln Pro Glu Gln Val Ile Leu Tyr Gln Gly Gly Gln Met 
65                  70                  75                  80  


Phe Asp Gly Ala Pro Arg Phe His Gly Arg Val Gly Phe Thr Gly Thr 
                85                  90                  95      


Met Pro Ala Thr Asn Val Ser Ile Phe Ile Asn Asn Thr Gln Leu Ser 
            100                 105                 110         


Asp Thr Gly Thr Tyr Gln Cys Leu Val Asn Asn Leu Pro Asp Ile Gly 
        115                 120                 125             


Gly Arg Asn Ile Gly Val Thr Gly Leu Thr Val Leu Val Pro Pro Ser 
    130                 135                 140                 


Ala Pro His Cys Gln Ile Gln Gly Ser Gln Asp Ile Gly Ser Asp Val 
145                 150                 155                 160 


Ile Leu Leu Cys Ser Ser Glu Glu Gly Ile Pro Arg Pro Thr Tyr Leu 
                165                 170                 175     


Trp Glu Lys Leu Asp Asn Thr Leu Lys Leu Pro Pro Thr Ala Thr Gln 
            180                 185                 190         


Asp Gln Val Gln Gly Thr Val Thr Ile Arg Asn Ile Ser Ala Leu Ser 
        195                 200                 205             


Ser Ala Gln Pro Arg Asn Ile Gly Leu Ile Ala Gly Ala Ile Gly Thr 
    210                 215                 220                 


Gly Ala Val Ile Ile Ile Phe Cys Ile Ala Leu Ile Leu Gly Ala Phe 
225                 230                 235                 240 


Phe Tyr Trp Arg Ser Lys Asn Lys Glu Glu Glu Glu Glu Glu Ile Pro 
                245                 250                 255     


Asn Glu Ile Arg Glu Asp Asp Leu Pro Pro Lys Cys Ser Ser Ala Lys 
            260                 265                 270         


Ala Phe His Thr Glu Ile Ser Ser Ser Asp Asn Asn Thr Leu Thr Ser 
        275                 280                 285             


Ser Asn Ala Tyr Asn Ser Arg Tyr Trp Ser Asn Asn Pro Lys Val His 
    290                 295                 300                 


Arg Asn Thr Glu Ser Val Ser His Phe Ser Asp Leu Gly Gln Ser Phe 
305                 310                 315                 320 


Ser Phe His Ser Gly Asn Ala Asn Ile Pro Ser Ile Tyr Ala Asn Gly 
                325                 330                 335     


Thr His Leu Val Pro Gly Gln His Lys Thr Leu Val Val Thr Ala Asn 
            340                 345                 350         


Arg Gly Ser Ser Pro Gln Val Met Ser Arg Ser Asn Gly Ser Val Ser 
        355                 360                 365             


Arg Lys Pro Arg Pro Pro His Thr His Ser Tyr Thr Ile Ser His Ala 
    370                 375                 380                 


Thr Leu Glu Arg Ile Gly Ala Val Pro Val Met Val Pro Ala Gln Ser 
385                 390                 395                 400 


Arg Ala Gly Ser Leu Val 
                405     


<210>  6832
<211>  430
<212>  PRT
<213>  Homo Sapiens

<400>  6832

Met Ser Leu Val Glu Leu Leu Leu Trp Trp Asn Cys Phe Ser Arg Thr 
1               5                   10                  15      


Gly Val Ala Ala Ser Leu Glu Val Ser Glu Ser Pro Gly Ser Ile Gln 
            20                  25                  30          


Val Ala Arg Gly Gln Pro Ala Val Leu Pro Cys Thr Phe Thr Thr Ser 
        35                  40                  45              


Ala Ala Leu Ile Asn Leu Asn Val Ile Trp Met Val Thr Pro Leu Ser 
    50                  55                  60                  


Asn Ala Asn Gln Pro Glu Gln Val Ile Leu Tyr Gln Gly Gly Gln Met 
65                  70                  75                  80  


Phe Asp Gly Ala Pro Arg Phe His Gly Arg Val Gly Phe Thr Gly Thr 
                85                  90                  95      


Met Pro Ala Thr Asn Val Ser Ile Phe Ile Asn Asn Thr Gln Leu Ser 
            100                 105                 110         


Asp Thr Gly Thr Tyr Gln Cys Leu Val Asn Asn Leu Pro Asp Ile Gly 
        115                 120                 125             


Gly Arg Asn Ile Gly Val Thr Gly Leu Thr Val Leu Val Pro Pro Ser 
    130                 135                 140                 


Ala Pro His Cys Gln Ile Gln Gly Ser Gln Asp Ile Gly Ser Asp Val 
145                 150                 155                 160 


Ile Leu Leu Cys Ser Ser Glu Glu Gly Ile Pro Arg Pro Thr Tyr Leu 
                165                 170                 175     


Trp Glu Lys Leu Asp Asn Thr Leu Lys Leu Pro Pro Thr Ala Thr Gln 
            180                 185                 190         


Asp Gln Val Gln Gly Thr Val Thr Ile Arg Asn Ile Ser Ala Leu Ser 
        195                 200                 205             


Ser Gly Leu Tyr Gln Cys Val Ala Ser Asn Ala Ile Gly Thr Ser Thr 
    210                 215                 220                 


Cys Leu Leu Asp Leu Gln Val Ile Ser Pro Gln Pro Arg Asn Ile Gly 
225                 230                 235                 240 


Leu Ile Ala Gly Ala Ile Gly Thr Gly Ala Val Ile Ile Ile Phe Cys 
                245                 250                 255     


Ile Ala Leu Ile Leu Gly Ala Phe Phe Tyr Trp Arg Ser Lys Asn Lys 
            260                 265                 270         


Glu Glu Glu Glu Glu Glu Ile Pro Asn Glu Ile Arg Glu Asp Asp Leu 
        275                 280                 285             


Pro Pro Lys Cys Ser Ser Ala Lys Ala Phe His Thr Glu Ile Ser Ser 
    290                 295                 300                 


Ser Asp Asn Asn Thr Leu Thr Ser Ser Asn Ala Tyr Asn Ser Arg Tyr 
305                 310                 315                 320 


Trp Ser Asn Asn Pro Lys Val His Arg Asn Thr Glu Ser Val Ser His 
                325                 330                 335     


Phe Ser Asp Leu Gly Gln Ser Phe Ser Phe His Ser Gly Asn Ala Asn 
            340                 345                 350         


Ile Pro Ser Ile Tyr Ala Asn Gly Thr His Leu Val Pro Gly Gln His 
        355                 360                 365             


Lys Thr Leu Val Val Thr Ala Asn Arg Gly Ser Ser Pro Gln Val Met 
    370                 375                 380                 


Ser Arg Ser Asn Gly Ser Val Ser Arg Lys Pro Arg Pro Pro His Thr 
385                 390                 395                 400 


His Ser Tyr Thr Ile Ser His Ala Thr Leu Glu Arg Ile Gly Ala Val 
                405                 410                 415     


Pro Val Met Val Pro Ala Gln Ser Arg Ala Gly Ser Leu Val 
            420                 425                 430 


<210>  6833
<211>  430
<212>  PRT
<213>  Homo Sapiens

<400>  6833

Met Ser Leu Val Glu Leu Leu Leu Trp Trp Asn Cys Phe Ser Arg Thr 
1               5                   10                  15      


Gly Val Ala Ala Ser Leu Glu Val Ser Glu Ser Pro Gly Ser Ile Gln 
            20                  25                  30          


Val Ala Arg Gly Gln Pro Ala Val Leu Pro Cys Thr Phe Thr Thr Ser 
        35                  40                  45              


Ala Ala Leu Ile Asn Leu Asn Val Ile Trp Met Val Thr Pro Leu Ser 
    50                  55                  60                  


Asn Ala Asn Gln Pro Glu Gln Val Ile Leu Tyr Gln Gly Gly Gln Met 
65                  70                  75                  80  


Phe Asp Gly Ala Pro Arg Phe His Gly Arg Val Gly Phe Thr Gly Thr 
                85                  90                  95      


Met Pro Ala Thr Asn Val Ser Ile Phe Ile Asn Asn Thr Gln Leu Ser 
            100                 105                 110         


Asp Thr Gly Thr Tyr Gln Cys Leu Val Asn Asn Leu Pro Asp Ile Gly 
        115                 120                 125             


Gly Arg Asn Ile Gly Val Thr Gly Leu Thr Val Leu Val Pro Pro Ser 
    130                 135                 140                 


Ala Pro His Cys Gln Ile Gln Gly Ser Gln Asp Ile Gly Ser Asp Val 
145                 150                 155                 160 


Ile Leu Leu Cys Ser Ser Glu Glu Gly Ile Pro Arg Pro Thr Tyr Leu 
                165                 170                 175     


Trp Glu Lys Leu Asp Asn Thr Leu Lys Leu Pro Pro Thr Ala Thr Gln 
            180                 185                 190         


Asp Gln Val Gln Gly Thr Val Thr Ile Arg Asn Ile Ser Ala Leu Ser 
        195                 200                 205             


Ser Gly Leu Tyr Gln Cys Val Ala Ser Asn Ala Ile Gly Thr Ser Thr 
    210                 215                 220                 


Cys Leu Leu Asp Leu Gln Val Ile Ser Pro Gln Pro Arg Asn Ile Gly 
225                 230                 235                 240 


Leu Ile Ala Gly Ala Ile Gly Thr Gly Ala Val Ile Ile Ile Phe Cys 
                245                 250                 255     


Ile Ala Leu Ile Leu Gly Ala Phe Phe Tyr Trp Arg Ser Lys Asn Lys 
            260                 265                 270         


Glu Glu Glu Glu Glu Glu Ile Pro Asn Glu Ile Arg Glu Asp Asp Leu 
        275                 280                 285             


Pro Pro Lys Cys Ser Ser Ala Lys Ala Phe His Thr Glu Ile Ser Ser 
    290                 295                 300                 


Ser Asp Asn Asn Thr Leu Thr Ser Ser Asn Ala Tyr Asn Ser Arg Tyr 
305                 310                 315                 320 


Trp Ser Asn Asn Pro Lys Val His Arg Asn Thr Glu Ser Val Ser His 
                325                 330                 335     


Phe Ser Asp Leu Gly Gln Ser Phe Ser Phe His Ser Gly Asn Ala Asn 
            340                 345                 350         


Ile Pro Ser Ile Tyr Ala Asn Gly Thr His Leu Val Pro Gly Gln His 
        355                 360                 365             


Lys Thr Leu Val Val Thr Ala Asn Arg Gly Ser Ser Pro Gln Val Met 
    370                 375                 380                 


Ser Arg Ser Asn Gly Ser Val Ser Arg Lys Pro Arg Pro Pro His Thr 
385                 390                 395                 400 


His Ser Tyr Thr Ile Ser His Ala Thr Leu Glu Arg Ile Gly Ala Val 
                405                 410                 415     


Pro Val Met Val Pro Ala Gln Ser Arg Ala Gly Ser Leu Val 
            420                 425                 430 


<210>  6834
<211>  407
<212>  PRT
<213>  Homo Sapiens

<400>  6834

Met Thr Ser Gln Arg Ser Pro Leu Ala Pro Leu Leu Leu Leu Ser Leu 
1               5                   10                  15      


His Gly Val Ala Ala Ser Leu Glu Val Ser Glu Ser Pro Gly Ser Ile 
            20                  25                  30          


Gln Val Ala Arg Gly Gln Pro Ala Val Leu Pro Cys Thr Phe Thr Thr 
        35                  40                  45              


Ser Ala Ala Leu Ile Asn Leu Asn Val Ile Trp Met Val Thr Pro Leu 
    50                  55                  60                  


Ser Asn Ala Asn Gln Pro Glu Gln Val Ile Leu Tyr Gln Gly Gly Gln 
65                  70                  75                  80  


Met Phe Asp Gly Ala Pro Arg Phe His Gly Arg Val Gly Phe Thr Gly 
                85                  90                  95      


Thr Met Pro Ala Thr Asn Val Ser Ile Phe Ile Asn Asn Thr Gln Leu 
            100                 105                 110         


Ser Asp Thr Gly Thr Tyr Gln Cys Leu Val Asn Asn Leu Pro Asp Ile 
        115                 120                 125             


Gly Gly Arg Asn Ile Gly Val Thr Gly Leu Thr Val Leu Val Pro Pro 
    130                 135                 140                 


Ser Ala Pro His Cys Gln Ile Gln Gly Ser Gln Asp Ile Gly Ser Asp 
145                 150                 155                 160 


Val Ile Leu Leu Cys Ser Ser Glu Glu Gly Ile Pro Arg Pro Thr Tyr 
                165                 170                 175     


Leu Trp Glu Lys Leu Asp Asn Thr Leu Lys Leu Pro Pro Thr Ala Thr 
            180                 185                 190         


Gln Asp Gln Val Gln Gly Thr Val Thr Ile Arg Asn Ile Ser Ala Leu 
        195                 200                 205             


Ser Ser Ala Gln Pro Arg Asn Ile Gly Leu Ile Ala Gly Ala Ile Gly 
    210                 215                 220                 


Thr Gly Ala Val Ile Ile Ile Phe Cys Ile Ala Leu Ile Leu Gly Ala 
225                 230                 235                 240 


Phe Phe Tyr Trp Arg Ser Lys Asn Lys Glu Glu Glu Glu Glu Glu Ile 
                245                 250                 255     


Pro Asn Glu Ile Arg Glu Asp Asp Leu Pro Pro Lys Cys Ser Ser Ala 
            260                 265                 270         


Lys Ala Phe His Thr Glu Ile Ser Ser Ser Asp Asn Asn Thr Leu Thr 
        275                 280                 285             


Ser Ser Asn Ala Tyr Asn Ser Arg Tyr Trp Ser Asn Asn Pro Lys Val 
    290                 295                 300                 


His Arg Asn Thr Glu Ser Val Ser His Phe Ser Asp Leu Gly Gln Ser 
305                 310                 315                 320 


Phe Ser Phe His Ser Gly Asn Ala Asn Ile Pro Ser Ile Tyr Ala Asn 
                325                 330                 335     


Gly Thr His Leu Val Pro Gly Gln His Lys Thr Leu Val Val Thr Ala 
            340                 345                 350         


Asn Arg Gly Ser Ser Pro Gln Val Met Ser Arg Ser Asn Gly Ser Val 
        355                 360                 365             


Ser Arg Lys Pro Arg Pro Pro His Thr His Ser Tyr Thr Ile Ser His 
    370                 375                 380                 


Ala Thr Leu Glu Arg Ile Gly Ala Val Pro Val Met Val Pro Ala Gln 
385                 390                 395                 400 


Ser Arg Ala Gly Ser Leu Val 
                405         


<210>  6835
<211>  431
<212>  PRT
<213>  Homo Sapiens

<400>  6835

Met Thr Ser Gln Arg Ser Pro Leu Ala Pro Leu Leu Leu Leu Ser Leu 
1               5                   10                  15      


His Gly Val Ala Ala Ser Leu Glu Val Ser Glu Ser Pro Gly Ser Ile 
            20                  25                  30          


Gln Val Ala Arg Gly Gln Pro Ala Val Leu Pro Cys Thr Phe Thr Thr 
        35                  40                  45              


Ser Ala Ala Leu Ile Asn Leu Asn Val Ile Trp Met Val Thr Pro Leu 
    50                  55                  60                  


Ser Asn Ala Asn Gln Pro Glu Gln Val Ile Leu Tyr Gln Gly Gly Gln 
65                  70                  75                  80  


Met Phe Asp Gly Ala Pro Arg Phe His Gly Arg Val Gly Phe Thr Gly 
                85                  90                  95      


Thr Met Pro Ala Thr Asn Val Ser Ile Phe Ile Asn Asn Thr Gln Leu 
            100                 105                 110         


Ser Asp Thr Gly Thr Tyr Gln Cys Leu Val Asn Asn Leu Pro Asp Ile 
        115                 120                 125             


Gly Gly Arg Asn Ile Gly Val Thr Gly Leu Thr Val Leu Val Pro Pro 
    130                 135                 140                 


Ser Ala Pro His Cys Gln Ile Gln Gly Ser Gln Asp Ile Gly Ser Asp 
145                 150                 155                 160 


Val Ile Leu Leu Cys Ser Ser Glu Glu Gly Ile Pro Arg Pro Thr Tyr 
                165                 170                 175     


Leu Trp Glu Lys Leu Asp Asn Thr Leu Lys Leu Pro Pro Thr Ala Thr 
            180                 185                 190         


Gln Asp Gln Val Gln Gly Thr Val Thr Ile Arg Asn Ile Ser Ala Leu 
        195                 200                 205             


Ser Ser Gly Leu Tyr Gln Cys Val Ala Ser Asn Ala Ile Gly Thr Ser 
    210                 215                 220                 


Thr Cys Leu Leu Asp Leu Gln Val Ile Ser Pro Gln Pro Arg Asn Ile 
225                 230                 235                 240 


Gly Leu Ile Ala Gly Ala Ile Gly Thr Gly Ala Val Ile Ile Ile Phe 
                245                 250                 255     


Cys Ile Ala Leu Ile Leu Gly Ala Phe Phe Tyr Trp Arg Ser Lys Asn 
            260                 265                 270         


Lys Glu Glu Glu Glu Glu Glu Ile Pro Asn Glu Ile Arg Glu Asp Asp 
        275                 280                 285             


Leu Pro Pro Lys Cys Ser Ser Ala Lys Ala Phe His Thr Glu Ile Ser 
    290                 295                 300                 


Ser Ser Asp Asn Asn Thr Leu Thr Ser Ser Asn Ala Tyr Asn Ser Arg 
305                 310                 315                 320 


Tyr Trp Ser Asn Asn Pro Lys Val His Arg Asn Thr Glu Ser Val Ser 
                325                 330                 335     


His Phe Ser Asp Leu Gly Gln Ser Phe Ser Phe His Ser Gly Asn Ala 
            340                 345                 350         


Asn Ile Pro Ser Ile Tyr Ala Asn Gly Thr His Leu Val Pro Gly Gln 
        355                 360                 365             


His Lys Thr Leu Val Val Thr Ala Asn Arg Gly Ser Ser Pro Gln Val 
    370                 375                 380                 


Met Ser Arg Ser Asn Gly Ser Val Ser Arg Lys Pro Arg Pro Pro His 
385                 390                 395                 400 


Thr His Ser Tyr Thr Ile Ser His Ala Thr Leu Glu Arg Ile Gly Ala 
                405                 410                 415     


Val Pro Val Met Val Pro Ala Gln Ser Arg Ala Gly Ser Leu Val 
            420                 425                 430     


<210>  6836
<211>  403
<212>  PRT
<213>  Homo Sapiens

<400>  6836

Met Thr Ser Gln Arg Ser Pro Leu Ala Pro Leu Leu Leu Leu Ser Leu 
1               5                   10                  15      


His Gly Val Ala Ala Ser Leu Glu Val Ser Glu Ser Pro Gly Ser Ile 
            20                  25                  30          


Gln Val Ala Arg Gly Gln Pro Ala Val Leu Pro Cys Thr Phe Thr Thr 
        35                  40                  45              


Ser Ala Ala Leu Ile Asn Leu Asn Val Ile Trp Met Val Thr Pro Leu 
    50                  55                  60                  


Ser Asn Ala Asn Gln Pro Glu Gln Val Ile Leu Tyr Gln Gly Gly Gln 
65                  70                  75                  80  


Met Phe Asp Gly Ala Pro Arg Phe His Gly Arg Val Gly Phe Thr Gly 
                85                  90                  95      


Thr Met Pro Ala Thr Asn Val Ser Ile Phe Ile Asn Asn Thr Gln Leu 
            100                 105                 110         


Ser Asp Thr Gly Thr Tyr Gln Cys Leu Val Asn Asn Leu Pro Asp Ile 
        115                 120                 125             


Gly Gly Arg Asn Ile Gly Val Thr Gly Leu Thr Val Leu Val Pro Pro 
    130                 135                 140                 


Ser Ala Pro His Cys Gln Ile Gln Gly Ser Gln Asp Ile Gly Ser Asp 
145                 150                 155                 160 


Val Ile Leu Leu Cys Ser Ser Glu Glu Gly Ile Pro Arg Pro Thr Tyr 
                165                 170                 175     


Leu Trp Glu Lys Leu Asp Asn Thr Leu Lys Leu Pro Pro Thr Ala Thr 
            180                 185                 190         


Gln Asp Gln Val Gln Gly Thr Val Thr Ile Arg Asn Ile Ser Ala Leu 
        195                 200                 205             


Ser Ser Gly Leu Tyr Gln Cys Val Ala Ser Asn Ala Ile Gly Thr Ser 
    210                 215                 220                 


Thr Cys Leu Leu Asp Leu Gln Val Ile Ser Arg Ala Phe Phe Tyr Trp 
225                 230                 235                 240 


Arg Ser Lys Asn Lys Glu Glu Glu Glu Glu Glu Ile Pro Asn Glu Ile 
                245                 250                 255     


Arg Glu Asp Asp Leu Pro Pro Lys Cys Ser Ser Ala Lys Ala Phe His 
            260                 265                 270         


Thr Glu Ile Ser Ser Ser Asp Asn Asn Thr Leu Thr Ser Ser Asn Ala 
        275                 280                 285             


Tyr Asn Ser Arg Tyr Trp Ser Asn Asn Pro Lys Val His Arg Asn Thr 
    290                 295                 300                 


Glu Ser Val Ser His Phe Ser Asp Leu Gly Gln Ser Phe Ser Phe His 
305                 310                 315                 320 


Ser Gly Asn Ala Asn Ile Pro Ser Ile Tyr Ala Asn Gly Thr His Leu 
                325                 330                 335     


Val Pro Gly Gln His Lys Thr Leu Val Val Thr Ala Asn Arg Gly Ser 
            340                 345                 350         


Ser Pro Gln Val Met Ser Arg Ser Asn Gly Ser Val Ser Arg Lys Pro 
        355                 360                 365             


Arg Pro Pro His Thr His Ser Tyr Thr Ile Ser His Ala Thr Leu Glu 
    370                 375                 380                 


Arg Ile Gly Ala Val Pro Val Met Val Pro Ala Gln Ser Arg Ala Gly 
385                 390                 395                 400 


Ser Leu Val 
            


<210>  6837
<211>  33
<212>  PRT
<213>  Homo Sapiens

<400>  6837

Met Val Thr Pro Leu Ser Asn Ala Asn Gln Pro Glu Gln Val Ile Leu 
1               5                   10                  15      


Tyr Gln Gly Gly Gln Met Phe Asp Gly Ala Pro Arg Phe His Gly Arg 
            20                  25                  30          


Val 
    


<210>  6838
<211>  59
<212>  PRT
<213>  Homo Sapiens

<400>  6838

Met Val Thr Pro Leu Ser Asn Ala Asn Gln Pro Glu Gln Val Ile Leu 
1               5                   10                  15      


Tyr Gln Gly Gly Gln Met Phe Asp Gly Ala Pro Arg Phe His Gly Arg 
            20                  25                  30          


Val Gly Phe Thr Gly Thr Met Pro Ala Thr Asn Val Ser Ile Phe Ile 
        35                  40                  45              


Asn Asn Thr Gln Leu Ser Asp Thr Gly Thr Tyr 
    50                  55                  


<210>  6839
<211>  467
<212>  PRT
<213>  Homo Sapiens

<400>  6839

Met Arg Thr Ala Pro Ser Leu Arg Arg Cys Val Cys Leu Leu Leu Ala 
1               5                   10                  15      


Ala Ile Leu Asp Leu Ala Arg Gly Tyr Leu Thr Val Asn Ile Glu Pro 
            20                  25                  30          


Leu Pro Pro Val Val Ala Gly Asp Ala Val Thr Leu Lys Cys Asn Phe 
        35                  40                  45              


Lys Thr Asp Gly Arg Met Arg Glu Ile Val Trp Tyr Arg Val Thr Asp 
    50                  55                  60                  


Gly Gly Thr Ile Lys Gln Lys Ile Phe Thr Phe Asp Ala Met Phe Ser 
65                  70                  75                  80  


Thr Asn Tyr Ser His Met Glu Asn Tyr Arg Lys Arg Glu Asp Leu Val 
                85                  90                  95      


Tyr Gln Ser Thr Val Arg Leu Pro Glu Val Arg Ile Ser Asp Asn Gly 
            100                 105                 110         


Pro Tyr Glu Cys His Val Gly Ile Tyr Asp Arg Ala Thr Arg Glu Lys 
        115                 120                 125             


Val Val Leu Ala Ser Gly Asn Ile Phe Leu Asn Val Met Ala Pro Pro 
    130                 135                 140                 


Thr Ser Ile Glu Val Val Ala Ala Asp Thr Pro Ala Pro Phe Ser Arg 
145                 150                 155                 160 


Tyr Gln Ala Gln Asn Phe Thr Leu Val Cys Ile Val Ser Gly Gly Lys 
                165                 170                 175     


Pro Ala Pro Met Val Tyr Phe Lys Arg Asp Gly Glu Pro Ile Asp Ala 
            180                 185                 190         


Val Pro Leu Ser Glu Pro Pro Ala Ala Ser Ser Gly Pro Leu Gln Asp 
        195                 200                 205             


Ser Arg Pro Phe Arg Ser Leu Leu His Arg Asp Leu Asp Asp Thr Lys 
    210                 215                 220                 


Met Gln Lys Ser Leu Ser Leu Leu Asp Ala Glu Asn Arg Gly Gly Arg 
225                 230                 235                 240 


Pro Tyr Thr Glu Arg Pro Ser Arg Gly Leu Thr Pro Asp Pro Asn Ile 
                245                 250                 255     


Leu Leu Gln Pro Thr Thr Glu Asn Ile Pro Glu Thr Val Val Ser Arg 
            260                 265                 270         


Glu Phe Pro Arg Trp Val His Ser Ala Glu Pro Thr Tyr Phe Leu Arg 
        275                 280                 285             


His Ser Arg Thr Pro Ser Ser Asp Gly Thr Val Glu Val Arg Ala Leu 
    290                 295                 300                 


Leu Thr Trp Thr Leu Asn Pro Gln Ile Asp Asn Glu Ala Leu Phe Ser 
305                 310                 315                 320 


Cys Glu Val Lys His Pro Ala Leu Ser Met Pro Met Gln Ala Glu Val 
                325                 330                 335     


Thr Leu Val Ala Pro Lys Gly Pro Lys Ile Val Met Thr Pro Ser Arg 
            340                 345                 350         


Ala Arg Val Gly Asp Thr Val Arg Ile Leu Val His Gly Phe Gln Asn 
        355                 360                 365             


Glu Val Phe Pro Glu Pro Met Phe Thr Trp Thr Arg Val Gly Ser Arg 
    370                 375                 380                 


Leu Leu Asp Gly Ser Ala Glu Phe Asp Gly Lys Glu Leu Val Leu Glu 
385                 390                 395                 400 


Arg Val Pro Ala Glu Leu Asn Gly Ser Met Tyr Arg Cys Thr Ala Gln 
                405                 410                 415     


Asn Pro Leu Gly Ser Thr Asp Thr His Thr Arg Leu Ile Val Phe Glu 
            420                 425                 430         


Asn Pro Asn Ile Pro Arg Gly Thr Glu Asp Ser Asn Gly Ser Ile Gly 
        435                 440                 445             


Pro Thr Gly Ala Arg Leu Thr Leu Val Leu Ala Leu Thr Val Ile Leu 
    450                 455                 460                 


Glu Leu Thr 
465         


<210>  6840
<211>  613
<212>  PRT
<213>  Homo Sapiens

<400>  6840

Met Gly Ala Leu Arg Pro Thr Leu Leu Pro Pro Ser Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Met Leu Gly Met Gly Cys Trp Ala Arg Glu Val Leu Val 
            20                  25                  30          


Pro Glu Gly Pro Leu Tyr Arg Val Ala Gly Thr Ala Val Ser Ile Ser 
        35                  40                  45              


Cys Asn Val Thr Gly Tyr Glu Gly Pro Ala Gln Gln Asn Phe Glu Trp 
    50                  55                  60                  


Phe Leu Tyr Arg Pro Glu Ala Pro Asp Thr Ala Leu Gly Ile Val Ser 
65                  70                  75                  80  


Thr Lys Asp Thr Gln Phe Ser Tyr Ala Val Phe Lys Ser Arg Val Val 
                85                  90                  95      


Ala Gly Glu Val Gln Val Gln Arg Leu Gln Gly Asp Ala Val Val Leu 
            100                 105                 110         


Lys Ile Ala Arg Leu Gln Ala Gln Asp Ala Gly Ile Tyr Glu Cys His 
        115                 120                 125             


Thr Pro Ser Thr Asp Thr Arg Tyr Leu Gly Ser Tyr Ser Gly Lys Val 
    130                 135                 140                 


Glu Leu Arg Val Leu Pro Asp Val Leu Gln Val Ser Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Pro Arg Gly Arg Gln Ala Pro Thr Ser Pro Pro Arg Met Thr Val 
                165                 170                 175     


His Glu Gly Gln Glu Leu Ala Leu Gly Cys Leu Ala Arg Thr Ser Thr 
            180                 185                 190         


Gln Lys His Thr His Leu Ala Val Ser Phe Gly Arg Ser Val Pro Glu 
        195                 200                 205             


Ala Pro Val Gly Arg Ser Thr Leu Gln Glu Val Val Gly Ile Arg Ser 
    210                 215                 220                 


Asp Leu Ala Val Glu Ala Gly Ala Pro Tyr Ala Glu Arg Leu Ala Ala 
225                 230                 235                 240 


Gly Glu Leu Arg Leu Gly Lys Glu Gly Thr Asp Arg Tyr Arg Met Val 
                245                 250                 255     


Val Gly Gly Ala Gln Ala Gly Asp Ala Gly Thr Tyr His Cys Thr Ala 
            260                 265                 270         


Ala Glu Trp Ile Gln Asp Pro Asp Gly Ser Trp Ala Gln Ile Ala Glu 
        275                 280                 285             


Lys Arg Ala Val Leu Ala His Val Asp Val Gln Thr Leu Ser Ser Gln 
    290                 295                 300                 


Leu Ala Val Thr Val Gly Pro Gly Glu Arg Arg Ile Gly Pro Gly Glu 
305                 310                 315                 320 


Pro Leu Glu Leu Leu Cys Asn Val Ser Gly Ala Leu Pro Pro Ala Gly 
                325                 330                 335     


Arg His Ala Ala Tyr Ser Val Gly Trp Glu Met Ala Pro Ala Gly Ala 
            340                 345                 350         


Pro Gly Pro Gly Arg Leu Val Ala Gln Leu Asp Thr Glu Gly Val Gly 
        355                 360                 365             


Ser Leu Gly Pro Gly Tyr Glu Gly Arg His Ile Ala Met Glu Lys Val 
    370                 375                 380                 


Ala Ser Arg Thr Tyr Arg Leu Arg Leu Glu Ala Ala Arg Pro Gly Asp 
385                 390                 395                 400 


Ala Gly Thr Tyr Arg Cys Leu Ala Lys Ala Tyr Val Arg Gly Ser Gly 
                405                 410                 415     


Thr Arg Leu Arg Glu Ala Ala Ser Ala Arg Ser Arg Pro Leu Pro Val 
            420                 425                 430         


His Val Arg Glu Glu Gly Val Val Leu Glu Ala Val Ala Trp Leu Ala 
        435                 440                 445             


Gly Gly Thr Val Tyr Arg Gly Glu Thr Ala Ser Leu Leu Cys Asn Ile 
    450                 455                 460                 


Ser Val Arg Gly Gly Pro Pro Gly Leu Arg Leu Ala Ala Ser Trp Trp 
465                 470                 475                 480 


Val Glu Arg Pro Glu Asp Gly Glu Leu Ser Ser Val Pro Ala Gln Leu 
                485                 490                 495     


Val Gly Gly Val Gly Gln Asp Gly Val Ala Glu Leu Gly Val Arg Pro 
            500                 505                 510         


Gly Gly Gly Pro Val Ser Val Glu Leu Val Gly Pro Arg Ser His Arg 
        515                 520                 525             


Leu Arg Leu His Ser Leu Gly Pro Glu Asp Glu Gly Val Tyr His Cys 
    530                 535                 540                 


Ala Pro Ser Ala Trp Val Gln His Ala Asp Tyr Ser Trp Tyr Gln Ala 
545                 550                 555                 560 


Gly Ser Ala Arg Ser Gly Pro Val Thr Val Tyr Pro Tyr Met His Ala 
                565                 570                 575     


Leu Asp Thr Leu Phe Val Pro Leu Leu Val Gly Thr Gly Val Ala Leu 
            580                 585                 590         


Val Thr Gly Ala Thr Val Leu Gly Thr Ile Thr Cys Cys Phe Met Lys 
        595                 600                 605             


Arg Leu Arg Lys Arg 
    610             


<210>  6841
<211>  613
<212>  PRT
<213>  Homo Sapiens

<400>  6841

Met Gly Ala Leu Arg Pro Thr Leu Leu Pro Pro Ser Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Met Leu Gly Met Gly Cys Trp Ala Arg Glu Val Leu Val 
            20                  25                  30          


Pro Glu Gly Pro Leu Tyr Arg Val Ala Gly Thr Ala Val Ser Ile Ser 
        35                  40                  45              


Cys Asn Val Thr Gly Tyr Glu Gly Pro Ala Gln Gln Asn Phe Glu Trp 
    50                  55                  60                  


Phe Leu Tyr Arg Pro Glu Ala Pro Asp Thr Ala Leu Gly Ile Val Ser 
65                  70                  75                  80  


Thr Lys Asp Thr Gln Phe Ser Tyr Ala Val Phe Lys Ser Arg Val Val 
                85                  90                  95      


Ala Gly Glu Val Gln Val Gln Arg Leu Gln Gly Asp Ala Val Val Leu 
            100                 105                 110         


Lys Ile Ala Arg Leu Gln Ala Gln Asp Ala Gly Ile Tyr Glu Cys His 
        115                 120                 125             


Thr Pro Ser Thr Asp Thr Arg Tyr Leu Gly Ser Tyr Ser Gly Lys Val 
    130                 135                 140                 


Glu Leu Arg Val Leu Pro Asp Val Leu Gln Val Ser Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Pro Arg Gly Arg Gln Ala Pro Thr Ser Pro Pro Arg Met Thr Val 
                165                 170                 175     


His Glu Gly Gln Glu Leu Ala Leu Gly Cys Leu Ala Arg Thr Ser Thr 
            180                 185                 190         


Gln Lys His Thr His Leu Ala Val Ser Phe Gly Arg Ser Val Pro Glu 
        195                 200                 205             


Ala Pro Val Gly Arg Ser Thr Leu Gln Glu Val Val Gly Ile Arg Ser 
    210                 215                 220                 


Asp Leu Ala Val Glu Ala Gly Ala Pro Tyr Ala Glu Arg Leu Ala Ala 
225                 230                 235                 240 


Gly Glu Leu Arg Leu Gly Lys Glu Gly Thr Asp Arg Tyr Arg Met Val 
                245                 250                 255     


Val Gly Gly Ala Gln Ala Gly Asp Ala Gly Thr Tyr His Cys Thr Ala 
            260                 265                 270         


Ala Glu Trp Ile Gln Asp Pro Asp Gly Ser Trp Ala Gln Ile Ala Glu 
        275                 280                 285             


Lys Arg Ala Val Leu Ala His Val Asp Val Gln Thr Leu Ser Ser Gln 
    290                 295                 300                 


Leu Ala Val Thr Val Gly Pro Gly Glu Arg Arg Ile Gly Pro Gly Glu 
305                 310                 315                 320 


Pro Leu Glu Leu Leu Cys Asn Val Ser Gly Ala Leu Pro Pro Ala Gly 
                325                 330                 335     


Arg His Ala Ala Tyr Ser Val Gly Trp Glu Met Ala Pro Ala Gly Ala 
            340                 345                 350         


Pro Gly Pro Gly Arg Leu Val Ala Gln Leu Asp Thr Glu Gly Val Gly 
        355                 360                 365             


Ser Leu Gly Pro Gly Tyr Glu Gly Arg His Ile Ala Met Glu Lys Val 
    370                 375                 380                 


Ala Ser Arg Thr Tyr Arg Leu Arg Leu Glu Ala Ala Arg Pro Gly Asp 
385                 390                 395                 400 


Ala Gly Thr Tyr Arg Cys Leu Ala Lys Ala Tyr Val Arg Gly Ser Gly 
                405                 410                 415     


Thr Arg Leu Arg Glu Ala Ala Ser Ala Arg Ser Arg Pro Leu Pro Val 
            420                 425                 430         


His Val Arg Glu Glu Gly Val Val Leu Glu Ala Val Ala Trp Leu Ala 
        435                 440                 445             


Gly Gly Thr Val Tyr Arg Gly Glu Thr Ala Ser Leu Leu Cys Asn Ile 
    450                 455                 460                 


Ser Val Arg Gly Gly Pro Pro Gly Leu Arg Leu Ala Ala Ser Trp Trp 
465                 470                 475                 480 


Val Glu Arg Pro Glu Asp Gly Glu Leu Ser Ser Val Pro Ala Gln Leu 
                485                 490                 495     


Val Gly Gly Val Gly Gln Asp Gly Val Ala Glu Leu Gly Val Arg Pro 
            500                 505                 510         


Gly Gly Gly Pro Val Ser Val Glu Leu Val Gly Pro Arg Ser His Arg 
        515                 520                 525             


Leu Arg Leu His Ser Leu Gly Pro Glu Asp Glu Gly Val Tyr His Cys 
    530                 535                 540                 


Ala Pro Ser Ala Trp Val Gln His Ala Asp Tyr Ser Trp Tyr Gln Ala 
545                 550                 555                 560 


Gly Ser Ala Arg Ser Gly Pro Val Thr Val Tyr Pro Tyr Met His Ala 
                565                 570                 575     


Leu Asp Thr Leu Phe Val Pro Leu Leu Val Gly Thr Gly Val Ala Leu 
            580                 585                 590         


Val Thr Gly Ala Thr Val Leu Gly Thr Ile Thr Cys Cys Phe Met Lys 
        595                 600                 605             


Arg Leu Arg Lys Arg 
    610             


<210>  6842
<211>  301
<212>  PRT
<213>  Homo Sapiens

<400>  6842

Met Gly Ala Leu Arg Pro Thr Leu Leu Pro Pro Ser Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Met Leu Gly Met Gly Cys Trp Ala Arg Glu Val Leu Val 
            20                  25                  30          


Pro Glu Gly Pro Leu Tyr Arg Val Ala Gly Thr Ala Val Ser Ile Ser 
        35                  40                  45              


Cys Asn Val Thr Gly Tyr Glu Gly Pro Ala Gln Gln Asn Phe Glu Trp 
    50                  55                  60                  


Phe Leu Tyr Arg Pro Glu Ala Pro Asp Thr Ala Leu Gly Ile Val Ser 
65                  70                  75                  80  


Thr Lys Asp Thr Gln Phe Ser Tyr Ala Val Phe Lys Ser Arg Val Val 
                85                  90                  95      


Ala Gly Glu Val Gln Val Gln Arg Leu Gln Gly Asp Ala Val Val Leu 
            100                 105                 110         


Lys Ile Ala Arg Leu Gln Ala Gln Asp Ala Gly Ile Tyr Glu Cys His 
        115                 120                 125             


Thr Pro Ser Thr Asp Thr Arg Tyr Leu Gly Ser Tyr Ser Gly Lys Val 
    130                 135                 140                 


Glu Leu Arg Val Leu Pro Asp Val Leu Gln Val Ser Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Pro Arg Gly Arg Gln Ala Pro Thr Ser Pro Pro Arg Met Thr Val 
                165                 170                 175     


His Glu Gly Gln Glu Leu Ala Leu Gly Cys Leu Ala Arg Thr Ser Thr 
            180                 185                 190         


Gln Lys His Thr His Leu Ala Val Ser Phe Gly Arg Ser Val Pro Glu 
        195                 200                 205             


Ala Pro Val Gly Arg Ser Thr Leu Gln Glu Val Val Gly Ile Arg Ser 
    210                 215                 220                 


Asp Leu Ala Val Glu Ala Gly Ala Pro Tyr Ala Glu Arg Leu Ala Ala 
225                 230                 235                 240 


Gly Glu Leu Arg Leu Gly Lys Glu Gly Thr Asp Arg Tyr Arg Met Val 
                245                 250                 255     


Val Gly Gly Ala Gln Ala Gly Asp Ala Gly Thr Tyr His Cys Thr Ala 
            260                 265                 270         


Ala Glu Trp Ile Gln Asp Pro Asp Gly Ser Trp Ala Gln Ile Ala Glu 
        275                 280                 285             


Lys Arg Ala Val Leu Ala His Val Asp Val Gln Thr Leu 
    290                 295                 300     


<210>  6843
<211>  613
<212>  PRT
<213>  Homo Sapiens

<400>  6843

Met Gly Ala Leu Arg Pro Thr Leu Leu Pro Pro Ser Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Met Leu Gly Met Gly Cys Trp Ala Arg Glu Val Leu Val 
            20                  25                  30          


Pro Glu Gly Pro Leu Tyr Arg Val Ala Gly Thr Ala Val Ser Ile Ser 
        35                  40                  45              


Cys Asn Val Thr Gly Tyr Glu Gly Pro Ala Gln Gln Asn Phe Glu Trp 
    50                  55                  60                  


Phe Leu Tyr Arg Pro Glu Ala Pro Asp Thr Ala Leu Gly Ile Val Ser 
65                  70                  75                  80  


Thr Lys Asp Thr Gln Phe Ser Tyr Ala Val Phe Lys Ser Arg Val Val 
                85                  90                  95      


Ala Gly Glu Val Gln Val Gln Arg Leu Gln Gly Asp Ala Val Val Leu 
            100                 105                 110         


Lys Ile Ala Arg Leu Gln Ala Gln Asp Ala Gly Ile Tyr Glu Cys His 
        115                 120                 125             


Thr Pro Ser Thr Asp Thr Arg Tyr Leu Gly Ser Tyr Ser Gly Lys Val 
    130                 135                 140                 


Glu Leu Arg Val Leu Pro Asp Val Leu Gln Val Ser Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Pro Arg Gly Arg Gln Ala Pro Thr Ser Pro Pro Arg Met Thr Val 
                165                 170                 175     


His Glu Gly Gln Glu Leu Ala Leu Gly Cys Leu Ala Arg Thr Ser Thr 
            180                 185                 190         


Gln Lys His Thr His Leu Ala Val Ser Phe Gly Arg Ser Val Pro Glu 
        195                 200                 205             


Ala Pro Val Gly Arg Ser Thr Leu Gln Glu Val Val Gly Ile Arg Ser 
    210                 215                 220                 


Asp Leu Ala Val Glu Ala Gly Ala Pro Tyr Ala Glu Arg Leu Ala Ala 
225                 230                 235                 240 


Gly Glu Leu Arg Leu Gly Lys Glu Gly Thr Asp Arg Tyr Arg Met Val 
                245                 250                 255     


Val Gly Gly Ala Gln Ala Gly Asp Ala Gly Thr Tyr His Cys Thr Ala 
            260                 265                 270         


Ala Glu Trp Ile Gln Asp Pro Asp Gly Ser Trp Ala Gln Ile Ala Glu 
        275                 280                 285             


Lys Arg Ala Val Leu Ala His Val Asp Val Gln Thr Leu Ser Ser Gln 
    290                 295                 300                 


Leu Ala Val Thr Val Gly Pro Gly Glu Arg Arg Ile Gly Pro Gly Glu 
305                 310                 315                 320 


Pro Leu Glu Leu Leu Cys Asn Val Ser Gly Ala Leu Pro Pro Ala Gly 
                325                 330                 335     


Arg His Ala Ala Tyr Ser Val Gly Trp Glu Met Ala Pro Ala Gly Ala 
            340                 345                 350         


Pro Gly Pro Gly Arg Leu Val Ala Gln Leu Asp Thr Glu Gly Val Gly 
        355                 360                 365             


Ser Leu Gly Pro Gly Tyr Glu Gly Arg His Ile Ala Met Glu Lys Val 
    370                 375                 380                 


Ala Ser Arg Thr Tyr Arg Leu Arg Leu Glu Ala Ala Arg Pro Gly Asp 
385                 390                 395                 400 


Ala Gly Thr Tyr Arg Cys Leu Ala Lys Ala Tyr Val Arg Gly Ser Gly 
                405                 410                 415     


Thr Arg Leu Arg Glu Ala Ala Ser Ala Arg Ser Arg Pro Leu Pro Val 
            420                 425                 430         


His Val Arg Glu Glu Gly Val Val Leu Glu Ala Val Ala Trp Leu Ala 
        435                 440                 445             


Gly Gly Thr Val Tyr Arg Gly Glu Thr Ala Ser Leu Leu Cys Asn Ile 
    450                 455                 460                 


Ser Val Arg Gly Gly Pro Pro Gly Leu Arg Leu Ala Ala Ser Trp Trp 
465                 470                 475                 480 


Val Glu Arg Pro Glu Asp Gly Glu Leu Ser Ser Val Pro Ala Gln Leu 
                485                 490                 495     


Val Gly Gly Val Gly Gln Asp Gly Val Ala Glu Leu Gly Val Arg Pro 
            500                 505                 510         


Gly Gly Gly Pro Val Ser Val Glu Leu Val Gly Pro Arg Ser His Arg 
        515                 520                 525             


Leu Arg Leu His Ser Leu Gly Pro Glu Asp Glu Gly Val Tyr His Cys 
    530                 535                 540                 


Ala Pro Ser Ala Trp Val Gln His Ala Asp Tyr Ser Trp Tyr Gln Ala 
545                 550                 555                 560 


Gly Ser Ala Arg Ser Gly Pro Val Thr Val Tyr Pro Tyr Met His Ala 
                565                 570                 575     


Leu Asp Thr Leu Phe Val Pro Leu Leu Val Gly Thr Gly Val Ala Leu 
            580                 585                 590         


Val Thr Gly Ala Thr Val Leu Gly Thr Ile Thr Cys Cys Phe Met Lys 
        595                 600                 605             


Arg Leu Arg Lys Arg 
    610             


<210>  6844
<211>  1163
<212>  PRT
<213>  Homo Sapiens

<400>  6844

Met Val Trp Cys Leu Gly Leu Ala Val Leu Ser Leu Val Ile Ser Gln 
1               5                   10                  15      


Gly Ala Asp Gly Arg Gly Lys Pro Glu Val Val Ser Val Val Gly Arg 
            20                  25                  30          


Ala Gly Glu Ser Val Val Leu Gly Cys Asp Leu Leu Pro Pro Ala Gly 
        35                  40                  45              


Arg Pro Pro Leu His Val Ile Glu Trp Leu Arg Phe Gly Phe Leu Leu 
    50                  55                  60                  


Pro Ile Phe Ile Gln Phe Gly Leu Tyr Ser Pro Arg Ile Asp Pro Asp 
65                  70                  75                  80  


Tyr Val Gly Arg Val Arg Leu Gln Lys Gly Ala Ser Leu Gln Ile Glu 
                85                  90                  95      


Gly Leu Arg Val Glu Asp Gln Gly Trp Tyr Glu Cys Arg Val Phe Phe 
            100                 105                 110         


Leu Asp Gln His Ile Pro Glu Asp Asp Phe Ala Asn Gly Ser Trp Val 
        115                 120                 125             


His Leu Thr Val Asn Ser Pro Pro Gln Phe Gln Glu Thr Pro Pro Ala 
    130                 135                 140                 


Val Leu Glu Val Gln Glu Leu Glu Pro Val Thr Leu Arg Cys Val Ala 
145                 150                 155                 160 


Arg Gly Ser Pro Leu Pro His Val Thr Trp Lys Leu Arg Gly Lys Asp 
                165                 170                 175     


Leu Gly Gln Gly Gln Gly Gln Val Gln Val Gln Asn Gly Thr Leu Arg 
            180                 185                 190         


Ile Arg Arg Val Glu Arg Gly Ser Ser Gly Val Tyr Thr Cys Gln Ala 
        195                 200                 205             


Ser Ser Thr Glu Gly Ser Ala Thr His Ala Thr Gln Leu Leu Val Leu 
    210                 215                 220                 


Gly Pro Pro Val Ile Val Val Pro Pro Lys Asn Ser Thr Val Asn Ala 
225                 230                 235                 240 


Ser Gln Asp Val Ser Leu Ala Cys His Ala Glu Ala Tyr Pro Ala Asn 
                245                 250                 255     


Leu Thr Tyr Ser Trp Phe Gln Asp Asn Ile Asn Val Phe His Ile Ser 
            260                 265                 270         


Arg Leu Gln Pro Arg Val Arg Ile Leu Val Asp Gly Ser Leu Arg Leu 
        275                 280                 285             


Leu Ala Thr Gln Pro Asp Asp Ala Gly Cys Tyr Thr Cys Val Pro Ser 
    290                 295                 300                 


Asn Gly Leu Leu His Pro Pro Ser Ala Ser Ala Tyr Leu Thr Val Leu 
305                 310                 315                 320 


Cys Met Pro Gly Val Ile Arg Cys Pro Val Arg Ala Asn Pro Pro Leu 
                325                 330                 335     


Leu Phe Val Ser Trp Thr Lys Asp Gly Lys Ala Leu Gln Leu Asp Lys 
            340                 345                 350         


Phe Pro Gly Trp Ser Gln Gly Thr Glu Gly Ser Leu Ile Ile Ala Leu 
        355                 360                 365             


Gly Asn Glu Asp Ala Leu Gly Glu Tyr Ser Cys Thr Pro Tyr Asn Ser 
    370                 375                 380                 


Leu Gly Thr Ala Gly Pro Ser Pro Val Thr Arg Val Leu Leu Lys Ala 
385                 390                 395                 400 


Pro Pro Ala Phe Ile Glu Arg Pro Lys Glu Glu Tyr Phe Gln Glu Val 
                405                 410                 415     


Gly Arg Glu Leu Leu Ile Pro Cys Ser Ala Gln Gly Asp Pro Pro Pro 
            420                 425                 430         


Val Val Ser Trp Thr Lys Val Gly Arg Gly Leu Gln Gly Gln Ala Gln 
        435                 440                 445             


Val Asp Ser Asn Ser Ser Leu Ile Leu Arg Pro Leu Thr Lys Glu Ala 
    450                 455                 460                 


His Gly His Trp Glu Cys Ser Ala Ser Asn Ala Val Ala Arg Val Ala 
465                 470                 475                 480 


Thr Ser Thr Asn Val Tyr Val Leu Gly Thr Ser Pro His Val Val Thr 
                485                 490                 495     


Asn Val Ser Val Val Ala Leu Pro Lys Gly Ala Asn Val Ser Trp Glu 
            500                 505                 510         


Pro Gly Phe Asp Gly Gly Tyr Leu Gln Arg Phe Ser Val Trp Tyr Thr 
        515                 520                 525             


Pro Leu Ala Lys Arg Pro Asp Arg Met His His Asp Trp Val Ser Leu 
    530                 535                 540                 


Ala Val Pro Val Gly Ala Ala His Leu Leu Val Pro Gly Leu Gln Pro 
545                 550                 555                 560 


His Thr Gln Tyr Gln Phe Ser Val Leu Ala Gln Asn Lys Leu Gly Ser 
                565                 570                 575     


Gly Pro Phe Ser Glu Ile Val Leu Ser Ala Pro Glu Gly Leu Pro Thr 
            580                 585                 590         


Thr Pro Ala Ala Pro Gly Leu Pro Pro Thr Glu Ile Pro Pro Pro Leu 
        595                 600                 605             


Ser Pro Pro Arg Gly Leu Val Ala Val Arg Thr Pro Arg Gly Val Leu 
    610                 615                 620                 


Leu His Trp Asp Pro Pro Glu Leu Val Pro Lys Arg Leu Asp Gly Tyr 
625                 630                 635                 640 


Val Leu Glu Gly Arg Gln Gly Ser Gln Gly Trp Glu Val Leu Asp Pro 
                645                 650                 655     


Ala Val Ala Gly Thr Glu Thr Glu Leu Leu Val Pro Gly Leu Ile Lys 
            660                 665                 670         


Asp Val Leu Tyr Glu Phe Arg Leu Val Ala Phe Ala Gly Ser Phe Val 
        675                 680                 685             


Ser Asp Pro Ser Asn Thr Ala Asn Val Ser Thr Ser Gly Leu Glu Val 
    690                 695                 700                 


Tyr Pro Ser Arg Thr Gln Leu Pro Gly Leu Leu Pro Gln Pro Val Leu 
705                 710                 715                 720 


Ala Gly Val Val Gly Gly Val Cys Phe Leu Gly Val Ala Val Leu Val 
                725                 730                 735     


Ser Ile Leu Ala Gly Cys Leu Leu Asn Arg Arg Arg Ala Ala Arg Arg 
            740                 745                 750         


Arg Arg Lys Arg Leu Arg Gln Asp Pro Pro Leu Ile Phe Ser Pro Thr 
        755                 760                 765             


Gly Lys Ser Ala Ala Pro Ser Ala Leu Gly Ser Gly Ser Pro Asp Ser 
    770                 775                 780                 


Val Ala Lys Leu Lys Leu Gln Gly Ser Pro Val Pro Ser Leu Arg Gln 
785                 790                 795                 800 


Ser Leu Leu Trp Gly Asp Pro Ala Gly Thr Pro Ser Pro His Pro Asp 
                805                 810                 815     


Pro Pro Ser Ser Arg Gly Pro Leu Pro Leu Glu Pro Ile Cys Arg Gly 
            820                 825                 830         


Pro Asp Gly Arg Phe Val Met Gly Pro Thr Val Ala Ala Pro Gln Glu 
        835                 840                 845             


Arg Ser Gly Arg Glu Gln Ala Glu Pro Arg Thr Pro Ala Gln Arg Leu 
    850                 855                 860                 


Ala Arg Ser Phe Asp Cys Ser Ser Ser Ser Pro Ser Gly Ala Pro Gln 
865                 870                 875                 880 


Pro Leu Cys Ile Glu Asp Ile Ser Pro Val Ala Pro Pro Pro Ala Ala 
                885                 890                 895     


Pro Pro Ser Pro Leu Pro Gly Pro Gly Pro Leu Leu Gln Tyr Leu Ser 
            900                 905                 910         


Leu Pro Phe Phe Arg Glu Met Asn Val Asp Gly Asp Trp Pro Pro Leu 
        915                 920                 925             


Glu Glu Pro Ser Pro Ala Ala Pro Pro Asp Tyr Met Asp Thr Arg Arg 
    930                 935                 940                 


Cys Pro Thr Ser Ser Phe Leu Arg Ser Pro Glu Thr Pro Pro Val Ser 
945                 950                 955                 960 


Pro Arg Glu Ser Leu Pro Gly Ala Val Val Gly Ala Gly Ala Thr Ala 
                965                 970                 975     


Glu Pro Pro Tyr Thr Ala Leu Ala Asp Trp Thr Leu Arg Glu Arg Leu 
            980                 985                 990         


Leu Pro Gly Leu Leu Pro Ala Ala  Pro Arg Gly Ser Leu  Thr Ser Gln 
        995                 1000                 1005             


Ser Ser  Gly Arg Gly Ser Ala  Ser Phe Leu Arg Pro  Pro Ser Thr 
    1010                 1015                 1020             


Ala Pro  Ser Ala Gly Gly Ser  Tyr Leu Ser Pro Ala  Pro Gly Asp 
    1025                 1030                 1035             


Thr Ser  Ser Trp Ala Ser Gly  Pro Glu Arg Trp Pro  Arg Arg Glu 
    1040                 1045                 1050             


His Val  Val Thr Val Ser Lys  Arg Arg Asn Thr Ser  Val Asp Glu 
    1055                 1060                 1065             


Asn Tyr  Glu Trp Asp Ser Glu  Phe Pro Gly Asp Met  Glu Leu Leu 
    1070                 1075                 1080             


Glu Thr  Leu His Leu Gly Leu  Ala Ser Ser Arg Leu  Arg Pro Glu 
    1085                 1090                 1095             


Ala Glu  Pro Glu Leu Gly Val  Lys Thr Pro Glu Glu  Gly Cys Leu 
    1100                 1105                 1110             


Leu Asn  Thr Ala His Val Thr  Gly Pro Glu Ala Arg  Cys Ala Ala 
    1115                 1120                 1125             


Leu Arg  Glu Glu Phe Leu Ala  Phe Arg Arg Arg Arg  Asp Ala Thr 
    1130                 1135                 1140             


Arg Ala  Arg Leu Pro Ala Tyr  Arg Gln Pro Val Pro  His Pro Glu 
    1145                 1150                 1155             


Gln Ala  Thr Leu Leu 
    1160             


<210>  6845
<211>  1179
<212>  PRT
<213>  Homo Sapiens

<400>  6845

Met Val Trp Cys Leu Gly Leu Ala Val Leu Ser Leu Val Ile Ser Gln 
1               5                   10                  15      


Gly Ala Asp Gly Arg Gly Lys Pro Glu Val Val Ser Val Val Gly Arg 
            20                  25                  30          


Ala Gly Glu Ser Val Val Leu Gly Cys Asp Leu Leu Pro Pro Ala Gly 
        35                  40                  45              


Arg Pro Pro Leu His Val Ile Glu Trp Leu Arg Phe Gly Phe Leu Leu 
    50                  55                  60                  


Pro Ile Phe Ile Gln Phe Gly Leu Tyr Ser Pro Arg Ile Asp Pro Asp 
65                  70                  75                  80  


Tyr Val Gly Arg Val Arg Leu Gln Lys Gly Ala Ser Leu Gln Ile Glu 
                85                  90                  95      


Gly Leu Arg Val Glu Asp Gln Gly Trp Tyr Glu Cys Arg Val Phe Phe 
            100                 105                 110         


Leu Asp Gln His Ile Pro Glu Asp Asp Phe Ala Asn Gly Ser Trp Val 
        115                 120                 125             


His Leu Thr Val Asn Ser Pro Pro Gln Phe Gln Glu Thr Pro Pro Ala 
    130                 135                 140                 


Val Leu Glu Val Gln Glu Leu Glu Pro Val Thr Leu Arg Cys Val Ala 
145                 150                 155                 160 


Arg Gly Ser Pro Leu Pro His Val Thr Trp Lys Leu Arg Gly Lys Asp 
                165                 170                 175     


Leu Gly Gln Gly Gln Gly Gln Val Gln Val Gln Asn Gly Thr Leu Arg 
            180                 185                 190         


Ile Arg Arg Val Glu Arg Gly Ser Ser Gly Val Tyr Thr Cys Gln Ala 
        195                 200                 205             


Ser Ser Thr Glu Gly Ser Ala Thr His Ala Thr Gln Leu Leu Val Leu 
    210                 215                 220                 


Gly Pro Pro Val Ile Val Val Pro Pro Lys Asn Ser Thr Val Asn Ala 
225                 230                 235                 240 


Ser Gln Asp Val Ser Leu Ala Cys His Ala Glu Ala Tyr Pro Ala Asn 
                245                 250                 255     


Leu Thr Tyr Ser Trp Phe Gln Asp Asn Ile Asn Val Phe His Ile Ser 
            260                 265                 270         


Arg Leu Gln Pro Arg Val Arg Ile Leu Val Asp Gly Ser Leu Arg Leu 
        275                 280                 285             


Leu Ala Thr Gln Pro Asp Asp Ala Gly Cys Tyr Thr Cys Val Pro Ser 
    290                 295                 300                 


Asn Gly Leu Leu His Pro Pro Ser Ala Ser Ala Tyr Leu Thr Val Leu 
305                 310                 315                 320 


Tyr Pro Ala Gln Val Thr Ala Met Pro Pro Glu Thr Pro Leu Pro Ile 
                325                 330                 335     


Gly Met Pro Gly Val Ile Arg Cys Pro Val Arg Ala Asn Pro Pro Leu 
            340                 345                 350         


Leu Phe Val Ser Trp Thr Lys Asp Gly Lys Ala Leu Gln Leu Asp Lys 
        355                 360                 365             


Phe Pro Gly Trp Ser Gln Gly Thr Glu Gly Ser Leu Ile Ile Ala Leu 
    370                 375                 380                 


Gly Asn Glu Asp Ala Leu Gly Glu Tyr Ser Cys Thr Pro Tyr Asn Ser 
385                 390                 395                 400 


Leu Gly Thr Ala Gly Pro Ser Pro Val Thr Arg Val Leu Leu Lys Ala 
                405                 410                 415     


Pro Pro Ala Phe Ile Glu Arg Pro Lys Glu Glu Tyr Phe Gln Glu Val 
            420                 425                 430         


Gly Arg Glu Leu Leu Ile Pro Cys Ser Ala Gln Gly Asp Pro Pro Pro 
        435                 440                 445             


Val Val Ser Trp Thr Lys Val Gly Arg Gly Leu Gln Gly Gln Ala Gln 
    450                 455                 460                 


Val Asp Ser Asn Ser Ser Leu Ile Leu Arg Pro Leu Thr Lys Glu Ala 
465                 470                 475                 480 


His Gly His Trp Glu Cys Ser Ala Ser Asn Ala Val Ala Arg Val Ala 
                485                 490                 495     


Thr Ser Thr Asn Val Tyr Val Leu Gly Thr Ser Pro His Val Val Thr 
            500                 505                 510         


Asn Val Ser Val Val Ala Leu Pro Lys Gly Ala Asn Val Ser Trp Glu 
        515                 520                 525             


Pro Gly Phe Asp Gly Gly Tyr Leu Gln Arg Phe Ser Val Trp Tyr Thr 
    530                 535                 540                 


Pro Leu Ala Lys Arg Pro Asp Arg Met His His Asp Trp Val Ser Leu 
545                 550                 555                 560 


Ala Val Pro Val Gly Ala Ala His Leu Leu Val Pro Gly Leu Gln Pro 
                565                 570                 575     


His Thr Gln Tyr Gln Phe Ser Val Leu Ala Gln Asn Lys Leu Gly Ser 
            580                 585                 590         


Gly Pro Phe Ser Glu Ile Val Leu Ser Ala Pro Glu Gly Leu Pro Thr 
        595                 600                 605             


Thr Pro Ala Ala Pro Gly Leu Pro Pro Thr Glu Ile Pro Pro Pro Leu 
    610                 615                 620                 


Ser Pro Pro Arg Gly Leu Val Ala Val Arg Thr Pro Arg Gly Val Leu 
625                 630                 635                 640 


Leu His Trp Asp Pro Pro Glu Leu Val Pro Lys Arg Leu Asp Gly Tyr 
                645                 650                 655     


Val Leu Glu Gly Arg Gln Gly Ser Gln Gly Trp Glu Val Leu Asp Pro 
            660                 665                 670         


Ala Val Ala Gly Thr Glu Thr Glu Leu Leu Val Pro Gly Leu Ile Lys 
        675                 680                 685             


Asp Val Leu Tyr Glu Phe Arg Leu Val Ala Phe Ala Gly Ser Phe Val 
    690                 695                 700                 


Ser Asp Pro Ser Asn Thr Ala Asn Val Ser Thr Ser Gly Leu Glu Val 
705                 710                 715                 720 


Tyr Pro Ser Arg Thr Gln Leu Pro Gly Leu Leu Pro Gln Pro Val Leu 
                725                 730                 735     


Ala Gly Val Val Gly Gly Val Cys Phe Leu Gly Val Ala Val Leu Val 
            740                 745                 750         


Ser Ile Leu Ala Gly Cys Leu Leu Asn Arg Arg Arg Ala Ala Arg Arg 
        755                 760                 765             


Arg Arg Lys Arg Leu Arg Gln Asp Pro Pro Leu Ile Phe Ser Pro Thr 
    770                 775                 780                 


Gly Lys Ser Ala Ala Pro Ser Ala Leu Gly Ser Gly Ser Pro Asp Ser 
785                 790                 795                 800 


Val Ala Lys Leu Lys Leu Gln Gly Ser Pro Val Pro Ser Leu Arg Gln 
                805                 810                 815     


Ser Leu Leu Trp Gly Asp Pro Ala Gly Thr Pro Ser Pro His Pro Asp 
            820                 825                 830         


Pro Pro Ser Ser Arg Gly Pro Leu Pro Leu Glu Pro Ile Cys Arg Gly 
        835                 840                 845             


Pro Asp Gly Arg Phe Val Met Gly Pro Thr Val Ala Ala Pro Gln Glu 
    850                 855                 860                 


Arg Ser Gly Arg Glu Gln Ala Glu Pro Arg Thr Pro Ala Gln Arg Leu 
865                 870                 875                 880 


Ala Arg Ser Phe Asp Cys Ser Ser Ser Ser Pro Ser Gly Ala Pro Gln 
                885                 890                 895     


Pro Leu Cys Ile Glu Asp Ile Ser Pro Val Ala Pro Pro Pro Ala Ala 
            900                 905                 910         


Pro Pro Ser Pro Leu Pro Gly Pro Gly Pro Leu Leu Gln Tyr Leu Ser 
        915                 920                 925             


Leu Pro Phe Phe Arg Glu Met Asn Val Asp Gly Asp Trp Pro Pro Leu 
    930                 935                 940                 


Glu Glu Pro Ser Pro Ala Ala Pro Pro Asp Tyr Met Asp Thr Arg Arg 
945                 950                 955                 960 


Cys Pro Thr Ser Ser Phe Leu Arg Ser Pro Glu Thr Pro Pro Val Ser 
                965                 970                 975     


Pro Arg Glu Ser Leu Pro Gly Ala Val Val Gly Ala Gly Ala Thr Ala 
            980                 985                 990         


Glu Pro Pro Tyr Thr Ala Leu Ala  Asp Trp Thr Leu Arg  Glu Arg Leu 
        995                 1000                 1005             


Leu Pro  Gly Leu Leu Pro Ala  Ala Pro Arg Gly Ser  Leu Thr Ser 
    1010                 1015                 1020             


Gln Ser  Ser Gly Arg Gly Ser  Ala Ser Phe Leu Arg  Pro Pro Ser 
    1025                 1030                 1035             


Thr Ala  Pro Ser Ala Gly Gly  Ser Tyr Leu Ser Pro  Ala Pro Gly 
    1040                 1045                 1050             


Asp Thr  Ser Ser Trp Ala Ser  Gly Pro Glu Arg Trp  Pro Arg Arg 
    1055                 1060                 1065             


Glu His  Val Val Thr Val Ser  Lys Arg Arg Asn Thr  Ser Val Asp 
    1070                 1075                 1080             


Glu Asn  Tyr Glu Trp Asp Ser  Glu Phe Pro Gly Asp  Met Glu Leu 
    1085                 1090                 1095             


Leu Glu  Thr Leu His Leu Gly  Leu Ala Ser Ser Arg  Leu Arg Pro 
    1100                 1105                 1110             


Glu Ala  Glu Pro Glu Leu Gly  Val Lys Thr Pro Glu  Glu Gly Cys 
    1115                 1120                 1125             


Leu Leu  Asn Thr Ala His Val  Thr Gly Pro Glu Ala  Arg Cys Ala 
    1130                 1135                 1140             


Ala Leu  Arg Glu Glu Phe Leu  Ala Phe Arg Arg Arg  Arg Asp Ala 
    1145                 1150                 1155             


Thr Arg  Ala Arg Leu Pro Ala  Tyr Arg Gln Pro Val  Pro His Pro 
    1160                 1165                 1170             


Glu Gln  Ala Thr Leu Leu 
    1175                 


<210>  6846
<211>  717
<212>  PRT
<213>  Homo Sapiens

<400>  6846

Met Val Trp Cys Leu Gly Leu Ala Val Leu Ser Leu Val Ile Ser Gln 
1               5                   10                  15      


Gly Ala Asp Gly Arg Gly Lys Pro Glu Val Val Ser Val Val Gly Arg 
            20                  25                  30          


Ala Gly Glu Ser Val Val Leu Gly Cys Asp Leu Leu Pro Pro Ala Gly 
        35                  40                  45              


Arg Pro Pro Leu His Val Ile Glu Trp Leu Arg Phe Gly Phe Leu Leu 
    50                  55                  60                  


Pro Ile Phe Ile Gln Phe Gly Leu Tyr Ser Pro Arg Ile Asp Pro Asp 
65                  70                  75                  80  


Tyr Val Gly Arg Val Arg Leu Gln Lys Gly Ala Ser Leu Gln Ile Glu 
                85                  90                  95      


Gly Leu Arg Val Glu Asp Gln Gly Trp Tyr Glu Cys Arg Val Phe Phe 
            100                 105                 110         


Leu Asp Gln His Ile Pro Glu Asp Asp Phe Ala Asn Gly Ser Trp Val 
        115                 120                 125             


His Leu Thr Val Asn Ser Pro Pro Gln Phe Gln Glu Thr Pro Pro Ala 
    130                 135                 140                 


Val Leu Glu Val Gln Glu Leu Glu Pro Val Thr Leu Arg Cys Val Ala 
145                 150                 155                 160 


Arg Gly Ser Pro Leu Pro His Val Thr Trp Lys Leu Arg Gly Lys Asp 
                165                 170                 175     


Leu Gly Gln Gly Gln Gly Gln Val Gln Val Gln Asn Gly Thr Leu Arg 
            180                 185                 190         


Ile Arg Arg Val Glu Arg Gly Ser Ser Gly Val Tyr Thr Cys Gln Ala 
        195                 200                 205             


Ser Ser Thr Glu Gly Ser Ala Thr His Ala Thr Gln Leu Leu Val Leu 
    210                 215                 220                 


Gly Pro Pro Val Ile Val Val Pro Pro Lys Asn Ser Thr Val Asn Ala 
225                 230                 235                 240 


Ser Gln Asp Val Ser Leu Ala Cys His Ala Glu Ala Tyr Pro Ala Asn 
                245                 250                 255     


Leu Thr Tyr Ser Trp Phe Gln Asp Asn Ile Asn Val Phe His Ile Ser 
            260                 265                 270         


Arg Leu Gln Pro Arg Val Arg Ile Leu Val Asp Gly Ser Leu Arg Leu 
        275                 280                 285             


Leu Ala Thr Gln Pro Asp Asp Ala Gly Cys Tyr Thr Cys Val Pro Ser 
    290                 295                 300                 


Asn Gly Leu Leu His Pro Pro Ser Ala Ser Ala Tyr Leu Thr Val Leu 
305                 310                 315                 320 


Tyr Pro Ala Gln Val Thr Ala Met Pro Pro Glu Thr Pro Leu Pro Ile 
                325                 330                 335     


Gly Met Pro Gly Val Ile Arg Cys Pro Val Arg Ala Asn Pro Pro Leu 
            340                 345                 350         


Leu Phe Val Ser Trp Thr Lys Asp Gly Lys Ala Leu Gln Leu Asp Lys 
        355                 360                 365             


Phe Pro Gly Trp Ser Gln Gly Thr Glu Gly Ser Leu Ile Ile Ala Leu 
    370                 375                 380                 


Gly Asn Glu Asp Ala Leu Gly Glu Tyr Ser Cys Thr Pro Tyr Asn Ser 
385                 390                 395                 400 


Leu Gly Thr Ala Gly Pro Ser Pro Val Thr Arg Val Leu Leu Lys Ala 
                405                 410                 415     


Pro Pro Ala Phe Ile Glu Arg Pro Lys Glu Glu Tyr Phe Gln Glu Val 
            420                 425                 430         


Gly Arg Glu Leu Leu Ile Pro Cys Ser Ala Gln Gly Asp Pro Pro Pro 
        435                 440                 445             


Ala Ala Pro Pro Ser Pro Leu Pro Gly Pro Gly Pro Leu Leu Gln Tyr 
    450                 455                 460                 


Leu Ser Leu Pro Phe Phe Arg Glu Met Asn Val Asp Gly Asp Trp Pro 
465                 470                 475                 480 


Pro Leu Glu Glu Pro Ser Pro Ala Ala Pro Pro Asp Tyr Met Asp Thr 
                485                 490                 495     


Arg Arg Cys Pro Thr Ser Ser Phe Leu Arg Ser Pro Glu Thr Pro Pro 
            500                 505                 510         


Val Ser Pro Arg Glu Ser Leu Pro Gly Ala Val Val Gly Ala Gly Ala 
        515                 520                 525             


Thr Ala Glu Pro Pro Tyr Thr Ala Leu Ala Asp Trp Thr Leu Arg Glu 
    530                 535                 540                 


Arg Leu Leu Pro Gly Leu Leu Pro Ala Ala Pro Arg Gly Ser Leu Thr 
545                 550                 555                 560 


Ser Gln Ser Ser Gly Arg Gly Ser Ala Ser Phe Leu Arg Pro Pro Ser 
                565                 570                 575     


Thr Ala Pro Ser Ala Gly Gly Ser Tyr Leu Ser Pro Ala Pro Gly Asp 
            580                 585                 590         


Thr Ser Ser Trp Ala Ser Gly Pro Glu Arg Trp Pro Arg Arg Glu His 
        595                 600                 605             


Val Val Thr Val Ser Lys Arg Arg Asn Thr Ser Val Asp Glu Asn Tyr 
    610                 615                 620                 


Glu Trp Asp Ser Glu Phe Pro Gly Asp Met Glu Leu Leu Glu Thr Leu 
625                 630                 635                 640 


His Leu Gly Leu Ala Ser Ser Arg Leu Arg Pro Glu Ala Glu Pro Glu 
                645                 650                 655     


Leu Gly Val Lys Thr Pro Glu Glu Gly Cys Leu Leu Asn Thr Ala His 
            660                 665                 670         


Val Thr Gly Pro Glu Ala Arg Cys Ala Ala Leu Arg Glu Glu Phe Leu 
        675                 680                 685             


Ala Phe Arg Arg Arg Arg Asp Ala Thr Arg Ala Arg Leu Pro Ala Tyr 
    690                 695                 700                 


Arg Gln Pro Val Pro His Pro Glu Gln Ala Thr Leu Leu 
705                 710                 715         


<210>  6847
<211>  411
<212>  PRT
<213>  Homo Sapiens

<400>  6847

Met Ser Pro Ala Arg Leu Arg Pro Arg Leu His Phe Cys Leu Val Leu 
1               5                   10                  15      


Leu Leu Leu Leu Val Val Pro Ala Ala Trp Gly Cys Gly Pro Gly Arg 
            20                  25                  30          


Val Val Gly Ser Arg Arg Arg Pro Pro Arg Lys Leu Val Pro Leu Ala 
        35                  40                  45              


Tyr Lys Gln Phe Ser Pro Asn Val Pro Glu Lys Thr Leu Gly Ala Ser 
    50                  55                  60                  


Gly Arg Tyr Glu Gly Lys Ile Ala Arg Ser Ser Glu Arg Phe Lys Glu 
65                  70                  75                  80  


Leu Thr Pro Asn Tyr Asn Pro Asp Ile Ile Phe Lys Asp Glu Glu Asn 
                85                  90                  95      


Thr Gly Ala Asp Arg Leu Met Thr Gln Arg Cys Lys Asp Arg Leu Asn 
            100                 105                 110         


Ser Leu Ala Ile Ser Val Met Asn Gln Trp Pro Gly Val Lys Leu Arg 
        115                 120                 125             


Val Thr Glu Gly Trp Asp Glu Asp Gly His His Ser Glu Glu Ser Leu 
    130                 135                 140                 


His Tyr Glu Gly Arg Ala Val Asp Ile Thr Thr Ser Asp Arg Asp Arg 
145                 150                 155                 160 


Asn Lys Tyr Gly Leu Leu Ala Arg Leu Ala Val Glu Ala Gly Phe Asp 
                165                 170                 175     


Trp Val Tyr Tyr Glu Ser Lys Ala His Val His Cys Ser Val Lys Ser 
            180                 185                 190         


Glu His Ser Ala Ala Ala Lys Thr Gly Gly Cys Phe Pro Ala Gly Ala 
        195                 200                 205             


Gln Val Arg Leu Glu Ser Gly Ala Arg Val Ala Leu Ser Ala Val Arg 
    210                 215                 220                 


Pro Gly Asp Arg Val Leu Ala Met Gly Glu Asp Gly Ser Pro Thr Phe 
225                 230                 235                 240 


Ser Asp Val Leu Ile Phe Leu Asp Arg Glu Pro His Arg Leu Arg Ala 
                245                 250                 255     


Phe Gln Val Ile Glu Thr Gln Asp Pro Pro Arg Arg Leu Ala Leu Thr 
            260                 265                 270         


Pro Ala His Leu Leu Phe Thr Ala Asp Asn His Thr Glu Pro Ala Ala 
        275                 280                 285             


Arg Phe Arg Ala Thr Phe Ala Ser His Val Gln Pro Gly Gln Tyr Val 
    290                 295                 300                 


Leu Val Ala Gly Val Pro Gly Leu Gln Pro Ala Arg Val Ala Ala Val 
305                 310                 315                 320 


Ser Thr His Val Ala Leu Gly Ala Tyr Ala Pro Leu Thr Lys His Gly 
                325                 330                 335     


Thr Leu Val Val Glu Asp Val Val Ala Ser Cys Phe Ala Ala Val Ala 
            340                 345                 350         


Asp His His Leu Ala Gln Leu Ala Phe Trp Pro Leu Arg Leu Phe His 
        355                 360                 365             


Ser Leu Ala Trp Gly Ser Trp Thr Pro Gly Glu Gly Val His Trp Tyr 
    370                 375                 380                 


Pro Gln Leu Leu Tyr Arg Leu Gly Arg Leu Leu Leu Glu Glu Gly Ser 
385                 390                 395                 400 


Phe His Pro Leu Gly Met Ser Gly Ala Gly Ser 
                405                 410     


<210>  6848
<211>  178
<212>  PRT
<213>  Homo Sapiens

<400>  6848

Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Arg Asn 
        


<210>  6849
<211>  74
<212>  PRT
<213>  Homo Sapiens

<400>  6849

Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala Glu Asn Gln 
1               5                   10                  15      


Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu Gly Glu Asn Leu Lys 
            20                  25                  30          


Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu Pro Cys Glu 
        35                  40                  45              


Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn Ala Phe Asn Lys Leu 
    50                  55                  60                  


Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser 
65                  70                  


<210>  6850
<211>  199
<212>  PRT
<213>  Homo Sapiens

<400>  6850

Met Asn Cys Val Cys Arg Leu Val Leu Val Val Leu Ser Leu Trp Pro 
1               5                   10                  15      


Asp Thr Ala Val Ala Pro Gly Pro Pro Pro Gly Pro Pro Arg Val Ser 
            20                  25                  30          


Pro Asp Pro Arg Ala Glu Leu Asp Ser Thr Val Leu Leu Thr Arg Ser 
        35                  40                  45              


Leu Leu Ala Asp Thr Arg Gln Leu Ala Ala Gln Leu Arg Asp Lys Phe 
    50                  55                  60                  


Pro Ala Asp Gly Asp His Asn Leu Asp Ser Leu Pro Thr Leu Ala Met 
65                  70                  75                  80  


Ser Ala Gly Ala Leu Gly Ala Leu Gln Leu Pro Gly Val Leu Thr Arg 
                85                  90                  95      


Leu Arg Ala Asp Leu Leu Ser Tyr Leu Arg His Val Gln Trp Leu Arg 
            100                 105                 110         


Arg Ala Gly Gly Ser Ser Leu Lys Thr Leu Glu Pro Glu Leu Gly Thr 
        115                 120                 125             


Leu Gln Ala Arg Leu Asp Arg Leu Leu Arg Arg Leu Gln Leu Leu Met 
    130                 135                 140                 


Ser Arg Leu Ala Leu Pro Gln Pro Pro Pro Asp Pro Pro Ala Pro Pro 
145                 150                 155                 160 


Leu Ala Pro Pro Ser Ser Ala Trp Gly Gly Ile Arg Ala Ala His Ala 
                165                 170                 175     


Ile Leu Gly Gly Leu His Leu Thr Leu Asp Trp Ala Val Arg Gly Leu 
            180                 185                 190         


Leu Leu Leu Lys Thr Arg Leu 
        195                 


<210>  6851
<211>  199
<212>  PRT
<213>  Homo Sapiens

<400>  6851

Met Asn Cys Val Cys Arg Leu Val Leu Val Val Leu Ser Leu Trp Pro 
1               5                   10                  15      


Asp Thr Ala Val Ala Pro Gly Pro Pro Pro Gly Pro Pro Arg Val Ser 
            20                  25                  30          


Pro Asp Pro Arg Ala Glu Leu Asp Ser Thr Val Leu Leu Thr Arg Ser 
        35                  40                  45              


Leu Leu Ala Asp Thr Arg Gln Leu Ala Ala Gln Leu Arg Asp Lys Phe 
    50                  55                  60                  


Pro Ala Asp Gly Asp His Asn Leu Asp Ser Leu Pro Thr Leu Ala Met 
65                  70                  75                  80  


Ser Ala Gly Ala Leu Gly Ala Leu Gln Leu Pro Gly Val Leu Thr Arg 
                85                  90                  95      


Leu Arg Ala Asp Leu Leu Ser Tyr Leu Arg His Val Gln Trp Leu Arg 
            100                 105                 110         


Arg Ala Gly Gly Ser Ser Leu Lys Thr Leu Glu Pro Glu Leu Gly Thr 
        115                 120                 125             


Leu Gln Ala Arg Leu Asp Arg Leu Leu Arg Arg Leu Gln Leu Leu Met 
    130                 135                 140                 


Ser Arg Leu Ala Leu Pro Gln Pro Pro Pro Asp Pro Pro Ala Pro Pro 
145                 150                 155                 160 


Leu Ala Pro Pro Ser Ser Ala Trp Gly Gly Ile Arg Ala Ala His Ala 
                165                 170                 175     


Ile Leu Gly Gly Leu His Leu Thr Leu Asp Trp Ala Val Arg Gly Leu 
            180                 185                 190         


Leu Leu Leu Lys Thr Arg Leu 
        195                 


<210>  6852
<211>  40
<212>  PRT
<213>  Homo Sapiens

<400>  6852

Met Ser Ala Gly Ala Leu Gly Ala Leu Gln Leu Pro Gly Val Leu Thr 
1               5                   10                  15      


Arg Leu Arg Ala Asp Leu Leu Ser Tyr Leu Arg His Val Gln Trp Leu 
            20                  25                  30          


Arg Arg Ala Gly Gly Ser Ser Leu 
        35                  40  


<210>  6853
<211>  120
<212>  PRT
<213>  Homo Sapiens

<400>  6853

Met Ser Ala Gly Ala Leu Gly Ala Leu Gln Leu Pro Gly Val Leu Thr 
1               5                   10                  15      


Arg Leu Arg Ala Asp Leu Leu Ser Tyr Leu Arg His Val Gln Trp Leu 
            20                  25                  30          


Arg Arg Ala Gly Gly Ser Ser Leu Lys Thr Leu Glu Pro Glu Leu Gly 
        35                  40                  45              


Thr Leu Gln Ala Arg Leu Asp Arg Leu Leu Arg Arg Leu Gln Leu Leu 
    50                  55                  60                  


Met Ser Arg Leu Ala Leu Pro Gln Pro Pro Pro Asp Pro Pro Ala Pro 
65                  70                  75                  80  


Pro Leu Ala Pro Pro Ser Ser Ala Trp Gly Gly Ile Arg Ala Ala His 
                85                  90                  95      


Ala Ile Leu Gly Gly Leu His Leu Thr Leu Asp Trp Ala Val Arg Gly 
            100                 105                 110         


Leu Leu Leu Leu Lys Thr Arg Leu 
        115                 120 


<210>  6854
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  6854

Met Ser Ser Ser Cys Ser Gly Leu Ser Arg Val Leu Val Ala Val Ala 
1               5                   10                  15      


Thr Ala Leu Val Ser Ala Ser Ser Pro Cys Pro Gln Ala Trp Gly Pro 
            20                  25                  30          


Pro Asp Pro Pro Ala Arg Pro Val Val Ser Cys Gln Ala Ala Asp Tyr 
        35                  40                  45              


Glu Asn Phe Ser Cys Thr Trp Ser Pro Ser Gln Ile Ser Gly Leu Pro 
    50                  55                  60                  


Thr Arg Tyr Leu Thr Ser Tyr Arg Lys Lys Thr Val Leu Gly Ala Asp 
65                  70                  75                  80  


Ser Gln Arg Arg Ser Pro Ser Thr Gly Pro Trp Pro Cys Pro Gln Asp 
                85                  90                  95      


Pro Leu Gly Ala Ala Arg Cys Val Val His Gly Ala Glu Phe Trp Ser 
            100                 105                 110         


Gln Tyr Arg Ile Asn Val Thr Glu Val Asn Pro Leu Gly Ala Ser Thr 
        115                 120                 125             


Arg Leu Leu Asp Val Ser Leu Gln Ser Ile Leu Arg Pro Asp Pro Pro 
    130                 135                 140                 


Gln Gly Leu Arg Val Glu Ser Val 
145                 150         


<210>  6855
<211>  54
<212>  PRT
<213>  Homo Sapiens

<400>  6855

Met Ser Ser Ser Cys Ser Gly Leu Ser Arg Val Leu Val Ala Val Ala 
1               5                   10                  15      


Thr Ala Leu Val Ser Ala Ser Ser Pro Cys Pro Gln Ala Trp Gly Pro 
            20                  25                  30          


Pro Gly Thr Gln Cys Pro Gly Phe Gly Met Gly Ser Gln Ser Cys Ser 
        35                  40                  45              


Arg Asp Leu Thr Leu Gly 
    50                  


<210>  6856
<211>  139
<212>  PRT
<213>  Homo Sapiens

<400>  6856

Met Ser Ser Ser Cys Ser Gly Leu Ser Arg Val Leu Val Ala Val Ala 
1               5                   10                  15      


Thr Ala Leu Val Ser Ala Ser Ser Pro Cys Pro Gln Ala Trp Gly Pro 
            20                  25                  30          


Pro Gly Val Gln Tyr Gly Gln Pro Gly Arg Ser Val Lys Leu Cys Cys 
        35                  40                  45              


Pro Gly Val Thr Ala Gly Asp Pro Val Ser Trp Phe Arg Asp Gly Glu 
    50                  55                  60                  


Pro Lys Leu Leu Gln Gly Pro Asp Ser Gly Leu Gly His Glu Leu Val 
65                  70                  75                  80  


Leu Ala Gln Ala Asp Ser Thr Asp Glu Gly Thr Tyr Ile Cys Gln Thr 
                85                  90                  95      


Leu Asp Gly Ala Leu Gly Gly Thr Val Thr Leu Gln Leu Gly Tyr Pro 
            100                 105                 110         


Pro Ala Arg Pro Val Val Ser Cys Gln Ala Ala Asp Tyr Glu Asn Phe 
        115                 120                 125             


Ser Cys Thr Trp Ser Pro Ser Gln Ile Ser Gly 
    130                 135                 


<210>  6857
<211>  167
<212>  PRT
<213>  Homo Sapiens

<400>  6857

Met Ser Ser Ser Cys Ser Gly Leu Ser Arg Val Leu Val Ala Val Ala 
1               5                   10                  15      


Thr Ala Leu Val Ser Ala Ser Ser Pro Cys Pro Gln Ala Trp Gly Pro 
            20                  25                  30          


Pro Gly Val Gln Tyr Gly Gln Pro Gly Arg Ser Val Lys Leu Cys Cys 
        35                  40                  45              


Pro Gly Val Thr Ala Gly Asp Pro Val Ser Trp Phe Arg Asp Gly Glu 
    50                  55                  60                  


Pro Lys Leu Leu Gln Gly Pro Asp Ser Gly Leu Gly His Glu Leu Val 
65                  70                  75                  80  


Leu Ala Gln Ala Asp Ser Thr Asp Glu Gly Thr Tyr Ile Cys Gln Thr 
                85                  90                  95      


Leu Asp Gly Ala Leu Gly Gly Thr Val Thr Leu Gln Leu Gly Tyr Pro 
            100                 105                 110         


Pro Ala Arg Pro Val Val Ser Cys Gln Ala Ala Asp Tyr Glu Asn Phe 
        115                 120                 125             


Ser Cys Thr Trp Ser Pro Ser Gln Ile Ser Gly Leu Pro Thr Arg Tyr 
    130                 135                 140                 


Leu Thr Ser Tyr Arg Lys Lys Thr Val Leu Gly Ala Asp Ser Gln Arg 
145                 150                 155                 160 


Arg Ser Pro Ser Thr Gly Pro 
                165         


<210>  6858
<211>  422
<212>  PRT
<213>  Homo Sapiens

<400>  6858

Met Ser Ser Ser Cys Ser Gly Leu Ser Arg Val Leu Val Ala Val Ala 
1               5                   10                  15      


Thr Ala Leu Val Ser Ala Ser Ser Pro Cys Pro Gln Ala Trp Gly Pro 
            20                  25                  30          


Pro Gly Val Gln Tyr Gly Gln Pro Gly Arg Ser Val Lys Leu Cys Cys 
        35                  40                  45              


Pro Gly Val Thr Ala Gly Asp Pro Val Ser Trp Phe Arg Asp Gly Glu 
    50                  55                  60                  


Pro Lys Leu Leu Gln Gly Pro Asp Ser Gly Leu Gly His Glu Leu Val 
65                  70                  75                  80  


Leu Ala Gln Ala Asp Ser Thr Asp Glu Gly Thr Tyr Ile Cys Gln Thr 
                85                  90                  95      


Leu Asp Gly Ala Leu Gly Gly Thr Val Thr Leu Gln Leu Gly Tyr Pro 
            100                 105                 110         


Pro Ala Arg Pro Val Val Ser Cys Gln Ala Ala Asp Tyr Glu Asn Phe 
        115                 120                 125             


Ser Cys Thr Trp Ser Pro Ser Gln Ile Ser Gly Leu Pro Thr Arg Tyr 
    130                 135                 140                 


Leu Thr Ser Tyr Arg Lys Lys Thr Val Leu Gly Ala Asp Ser Gln Arg 
145                 150                 155                 160 


Arg Ser Pro Ser Thr Gly Pro Trp Pro Cys Pro Gln Asp Pro Leu Gly 
                165                 170                 175     


Ala Ala Arg Cys Val Val His Gly Ala Glu Phe Trp Ser Gln Tyr Arg 
            180                 185                 190         


Ile Asn Val Thr Glu Val Asn Pro Leu Gly Ala Ser Thr Arg Leu Leu 
        195                 200                 205             


Asp Val Ser Leu Gln Ser Ile Leu Arg Pro Asp Pro Pro Gln Gly Leu 
    210                 215                 220                 


Arg Val Glu Ser Val Pro Gly Tyr Pro Arg Arg Leu Arg Ala Ser Trp 
225                 230                 235                 240 


Thr Tyr Pro Ala Ser Trp Pro Cys Gln Pro His Phe Leu Leu Lys Phe 
                245                 250                 255     


Arg Leu Gln Tyr Arg Pro Ala Gln His Pro Ala Trp Ser Thr Val Glu 
            260                 265                 270         


Pro Ala Gly Leu Glu Glu Val Ile Thr Asp Ala Val Ala Gly Leu Pro 
        275                 280                 285             


His Ala Val Arg Val Ser Ala Arg Asp Phe Leu Asp Ala Gly Thr Trp 
    290                 295                 300                 


Ser Thr Trp Ser Pro Glu Ala Trp Gly Thr Pro Ser Thr Gly Thr Ile 
305                 310                 315                 320 


Pro Lys Glu Ile Pro Ala Trp Gly Gln Leu His Thr Gln Pro Glu Val 
                325                 330                 335     


Glu Pro Gln Val Asp Ser Pro Ala Pro Pro Arg Pro Ser Leu Gln Pro 
            340                 345                 350         


His Pro Arg Leu Leu Asp His Arg Asp Ser Val Glu Gln Val Ala Val 
        355                 360                 365             


Leu Ala Ser Leu Gly Ile Leu Ser Phe Leu Gly Leu Val Ala Gly Ala 
    370                 375                 380                 


Leu Ala Leu Gly Leu Trp Leu Arg Leu Arg Arg Gly Gly Lys Asp Gly 
385                 390                 395                 400 


Ser Pro Lys Pro Gly Phe Leu Ala Ser Val Ile Pro Val Asp Arg Arg 
                405                 410                 415     


Pro Gly Ala Pro Asn Leu 
            420         


<210>  6859
<211>  422
<212>  PRT
<213>  Homo Sapiens

<400>  6859

Met Ser Ser Ser Cys Ser Gly Leu Ser Arg Val Leu Val Ala Val Ala 
1               5                   10                  15      


Thr Ala Leu Val Ser Ala Ser Ser Pro Cys Pro Gln Ala Trp Gly Pro 
            20                  25                  30          


Pro Gly Val Gln Tyr Gly Gln Pro Gly Arg Ser Val Lys Leu Cys Cys 
        35                  40                  45              


Pro Gly Val Thr Ala Gly Asp Pro Val Ser Trp Phe Arg Asp Gly Glu 
    50                  55                  60                  


Pro Lys Leu Leu Gln Gly Pro Asp Ser Gly Leu Gly His Glu Leu Val 
65                  70                  75                  80  


Leu Ala Gln Ala Asp Ser Thr Asp Glu Gly Thr Tyr Ile Cys Gln Thr 
                85                  90                  95      


Leu Asp Gly Ala Leu Gly Gly Thr Val Thr Leu Gln Leu Gly Tyr Pro 
            100                 105                 110         


Pro Ala Arg Pro Val Val Ser Cys Gln Ala Ala Asp Tyr Glu Asn Phe 
        115                 120                 125             


Ser Cys Thr Trp Ser Pro Ser Gln Ile Ser Gly Leu Pro Thr Arg Tyr 
    130                 135                 140                 


Leu Thr Ser Tyr Arg Lys Lys Thr Val Leu Gly Ala Asp Ser Gln Arg 
145                 150                 155                 160 


Arg Ser Pro Ser Thr Gly Pro Trp Pro Cys Pro Gln Asp Pro Leu Gly 
                165                 170                 175     


Ala Ala Arg Cys Val Val His Gly Ala Glu Phe Trp Ser Gln Tyr Arg 
            180                 185                 190         


Ile Asn Val Thr Glu Val Asn Pro Leu Gly Ala Ser Thr Arg Leu Leu 
        195                 200                 205             


Asp Val Ser Leu Gln Ser Ile Leu Arg Pro Asp Pro Pro Gln Gly Leu 
    210                 215                 220                 


Arg Val Glu Ser Val Pro Gly Tyr Pro Arg Arg Leu Arg Ala Ser Trp 
225                 230                 235                 240 


Thr Tyr Pro Ala Ser Trp Pro Cys Gln Pro His Phe Leu Leu Lys Phe 
                245                 250                 255     


Arg Leu Gln Tyr Arg Pro Ala Gln His Pro Ala Trp Ser Thr Val Glu 
            260                 265                 270         


Pro Ala Gly Leu Glu Glu Val Ile Thr Asp Ala Val Ala Gly Leu Pro 
        275                 280                 285             


His Ala Val Arg Val Ser Ala Arg Asp Phe Leu Asp Ala Gly Thr Trp 
    290                 295                 300                 


Ser Thr Trp Ser Pro Glu Ala Trp Gly Thr Pro Ser Thr Gly Thr Ile 
305                 310                 315                 320 


Pro Lys Glu Ile Pro Ala Trp Gly Gln Leu His Thr Gln Pro Glu Val 
                325                 330                 335     


Glu Pro Gln Val Asp Ser Pro Ala Pro Pro Arg Pro Ser Leu Gln Pro 
            340                 345                 350         


His Pro Arg Leu Leu Asp His Arg Asp Ser Val Glu Gln Val Ala Val 
        355                 360                 365             


Leu Ala Ser Leu Gly Ile Leu Ser Phe Leu Gly Leu Val Ala Gly Ala 
    370                 375                 380                 


Leu Ala Leu Gly Leu Trp Leu Arg Leu Arg Arg Gly Gly Lys Asp Gly 
385                 390                 395                 400 


Ser Pro Lys Pro Gly Phe Leu Ala Ser Val Ile Pro Val Asp Arg Arg 
                405                 410                 415     


Pro Gly Ala Pro Asn Leu 
            420         


<210>  6860
<211>  270
<212>  PRT
<213>  Homo Sapiens

<400>  6860

Met Ser Ser Ser Cys Ser Gly Leu Ser Arg Val Leu Val Ala Val Ala 
1               5                   10                  15      


Thr Ala Leu Val Ser Ala Ser Ser Pro Cys Pro Gln Ala Trp Gly Pro 
            20                  25                  30          


Pro Gly Val Gln Tyr Gly Gln Pro Gly Arg Ser Val Lys Leu Cys Cys 
        35                  40                  45              


Pro Gly Val Thr Ala Gly Asp Pro Val Ser Trp Phe Arg Asp Gly Glu 
    50                  55                  60                  


Pro Lys Leu Leu Gln Gly Pro Asp Ser Gly Leu Gly His Glu Leu Val 
65                  70                  75                  80  


Leu Ala Gln Ala Asp Ser Thr Asp Glu Gly Thr Tyr Ile Cys Gln Thr 
                85                  90                  95      


Leu Asp Gly Ala Leu Gly Gly Thr Val Thr Leu Gln Leu Gly Tyr Pro 
            100                 105                 110         


Pro Ala Arg Pro Val Val Ser Cys Gln Ala Ala Asp Tyr Glu Asn Phe 
        115                 120                 125             


Ser Cys Thr Trp Ser Pro Ser Gln Ile Ser Gly Leu Pro Thr Arg Tyr 
    130                 135                 140                 


Leu Thr Ser Tyr Arg Lys Lys Thr Val Leu Gly Ala Asp Ser Gln Arg 
145                 150                 155                 160 


Arg Ser Pro Ser Thr Gly Pro Trp Pro Cys Pro Gln Asp Pro Leu Gly 
                165                 170                 175     


Ala Ala Arg Cys Val Val His Gly Ala Glu Phe Trp Ser Gln Tyr Arg 
            180                 185                 190         


Ile Asn Val Thr Glu Val Asn Pro Leu Gly Ala Ser Thr Arg Leu Leu 
        195                 200                 205             


Asp Val Ser Leu Gln Ser Ile Leu Arg Pro Asp Pro Pro Gln Gly Leu 
    210                 215                 220                 


Arg Val Glu Ser Val Pro Gly Tyr Pro Arg Arg Leu Arg Ala Ser Trp 
225                 230                 235                 240 


Thr Tyr Pro Ala Ser Trp Pro Cys Gln Pro His Phe Leu Leu Lys Phe 
                245                 250                 255     


Arg Leu Gln Tyr Arg Pro Ala Gln His Pro Ala Trp Ser Thr 
            260                 265                 270 


<210>  6861
<211>  390
<212>  PRT
<213>  Homo Sapiens

<400>  6861

Met Ser Ser Ser Cys Ser Gly Leu Ser Arg Val Leu Val Ala Val Ala 
1               5                   10                  15      


Thr Ala Leu Val Ser Ala Ser Ser Pro Cys Pro Gln Ala Trp Gly Pro 
            20                  25                  30          


Pro Gly Val Gln Tyr Gly Gln Pro Gly Arg Ser Val Lys Leu Cys Cys 
        35                  40                  45              


Pro Gly Val Thr Ala Gly Asp Pro Val Ser Trp Phe Arg Asp Gly Glu 
    50                  55                  60                  


Pro Lys Leu Leu Gln Gly Pro Asp Ser Gly Leu Gly His Glu Leu Val 
65                  70                  75                  80  


Leu Ala Gln Ala Asp Ser Thr Asp Glu Gly Thr Tyr Ile Cys Gln Thr 
                85                  90                  95      


Leu Asp Gly Ala Leu Gly Gly Thr Val Thr Leu Gln Leu Gly Tyr Pro 
            100                 105                 110         


Pro Ala Arg Pro Val Val Ser Cys Gln Ala Ala Asp Tyr Glu Asn Phe 
        115                 120                 125             


Ser Cys Thr Trp Ser Pro Ser Gln Ile Ser Gly Leu Pro Thr Arg Tyr 
    130                 135                 140                 


Leu Thr Ser Tyr Arg Lys Lys Thr Val Leu Gly Ala Asp Ser Gln Arg 
145                 150                 155                 160 


Arg Ser Pro Ser Thr Gly Pro Trp Pro Cys Pro Gln Asp Pro Leu Gly 
                165                 170                 175     


Ala Ala Arg Cys Val Val His Gly Ala Glu Phe Trp Ser Gln Tyr Arg 
            180                 185                 190         


Ile Asn Val Thr Glu Val Asn Pro Leu Gly Ala Ser Thr Arg Leu Leu 
        195                 200                 205             


Asp Val Ser Leu Gln Ser Ile Leu Arg Pro Asp Pro Pro Gln Gly Leu 
    210                 215                 220                 


Arg Val Glu Ser Val Pro Gly Tyr Pro Arg Arg Leu Arg Ala Ser Trp 
225                 230                 235                 240 


Thr Tyr Pro Ala Ser Trp Pro Cys Gln Pro His Phe Leu Leu Lys Phe 
                245                 250                 255     


Arg Leu Gln Tyr Arg Pro Ala Gln His Pro Ala Trp Ser Thr Val Glu 
            260                 265                 270         


Pro Ala Gly Leu Glu Glu Val Ile Thr Asp Ala Val Ala Gly Leu Pro 
        275                 280                 285             


His Ala Val Arg Val Ser Ala Arg Asp Phe Leu Asp Ala Gly Thr Trp 
    290                 295                 300                 


Ser Thr Trp Ser Pro Glu Ala Trp Gly Thr Pro Ser Thr Gly Thr Ile 
305                 310                 315                 320 


Pro Lys Glu Ile Pro Ala Trp Gly Gln Leu His Thr Gln Pro Glu Val 
                325                 330                 335     


Glu Pro Gln Val Asp Ser Pro Ala Pro Pro Arg Pro Ser Leu Gln Pro 
            340                 345                 350         


His Pro Arg Leu Leu Asp His Arg Asp Ser Val Glu Gln Val Ala Val 
        355                 360                 365             


Leu Ala Ser Leu Gly Ile Leu Ser Phe Leu Gly Leu Val Ala Gly Ala 
    370                 375                 380                 


Leu Ala Leu Gly Leu Trp 
385                 390 


<210>  6862
<211>  422
<212>  PRT
<213>  Homo Sapiens

<400>  6862

Met Ser Ser Ser Cys Ser Gly Leu Ser Arg Val Leu Val Ala Val Ala 
1               5                   10                  15      


Thr Ala Leu Val Ser Ala Ser Ser Pro Cys Pro Gln Ala Trp Gly Pro 
            20                  25                  30          


Pro Gly Val Gln Tyr Gly Gln Pro Gly Arg Ser Val Lys Leu Cys Cys 
        35                  40                  45              


Pro Gly Val Thr Ala Gly Asp Pro Val Ser Trp Phe Arg Asp Gly Glu 
    50                  55                  60                  


Pro Lys Leu Leu Gln Gly Pro Asp Ser Gly Leu Gly His Glu Leu Val 
65                  70                  75                  80  


Leu Ala Gln Ala Asp Ser Thr Asp Glu Gly Thr Tyr Ile Cys Gln Thr 
                85                  90                  95      


Leu Asp Gly Ala Leu Gly Gly Thr Val Thr Leu Gln Leu Gly Tyr Pro 
            100                 105                 110         


Pro Ala Arg Pro Val Val Ser Cys Gln Ala Ala Asp Tyr Glu Asn Phe 
        115                 120                 125             


Ser Cys Thr Trp Ser Pro Ser Gln Ile Ser Gly Leu Pro Thr Arg Tyr 
    130                 135                 140                 


Leu Thr Ser Tyr Arg Lys Lys Thr Val Leu Gly Ala Asp Ser Gln Arg 
145                 150                 155                 160 


Arg Ser Pro Ser Thr Gly Pro Trp Pro Cys Pro Gln Asp Pro Leu Gly 
                165                 170                 175     


Ala Ala Arg Cys Val Val His Gly Ala Glu Phe Trp Ser Gln Tyr Arg 
            180                 185                 190         


Ile Asn Val Thr Glu Val Asn Pro Leu Gly Ala Ser Thr Arg Leu Leu 
        195                 200                 205             


Asp Val Ser Leu Gln Ser Ile Leu Arg Pro Asp Pro Pro Gln Gly Leu 
    210                 215                 220                 


Arg Val Glu Ser Val Pro Gly Tyr Pro Arg Arg Leu Arg Ala Ser Trp 
225                 230                 235                 240 


Thr Tyr Pro Ala Ser Trp Pro Cys Gln Pro His Phe Leu Leu Lys Phe 
                245                 250                 255     


Arg Leu Gln Tyr Arg Pro Ala Gln His Pro Ala Trp Ser Thr Val Glu 
            260                 265                 270         


Pro Ala Gly Leu Glu Glu Val Ile Thr Asp Ala Val Ala Gly Leu Pro 
        275                 280                 285             


His Ala Val Arg Val Ser Ala Arg Asp Phe Leu Asp Ala Gly Thr Trp 
    290                 295                 300                 


Ser Thr Trp Ser Pro Glu Ala Trp Gly Thr Pro Ser Thr Gly Thr Ile 
305                 310                 315                 320 


Pro Lys Glu Ile Pro Ala Trp Gly Gln Leu His Thr Gln Pro Glu Val 
                325                 330                 335     


Glu Pro Gln Val Asp Ser Pro Ala Pro Pro Arg Pro Ser Leu Gln Pro 
            340                 345                 350         


His Pro Arg Leu Leu Asp His Arg Asp Ser Val Glu Gln Val Ala Val 
        355                 360                 365             


Leu Ala Ser Leu Gly Ile Leu Ser Phe Leu Gly Leu Val Ala Gly Ala 
    370                 375                 380                 


Leu Ala Leu Gly Leu Trp Leu Arg Leu Arg Arg Gly Gly Lys Asp Gly 
385                 390                 395                 400 


Ser Pro Lys Pro Gly Phe Leu Ala Ser Val Ile Pro Val Asp Arg Arg 
                405                 410                 415     


Pro Gly Ala Pro Asn Leu 
            420         


<210>  6863
<211>  68
<212>  PRT
<213>  Homo Sapiens

<400>  6863

Met Ser Ser Ser Cys Ser Gly Leu Ser Arg Val Leu Val Ala Val Ala 
1               5                   10                  15      


Thr Ala Leu Val Ser Ala Ser Ser Pro Cys Pro Gln Ala Trp Gly Pro 
            20                  25                  30          


Pro Gly Val Gln Tyr Gly Gln Pro Gly Arg Ser Val Lys Leu Cys Cys 
        35                  40                  45              


Pro Gly Val Thr Ala Gly Pro Ser Ser Pro Pro Cys Cys Leu Leu Pro 
    50                  55                  60                  


Ser Ser Arg Leu 
65              


<210>  6864
<211>  77
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6864

Xaa Thr Pro Ser Thr Gly Thr Ile Pro Lys Glu Ile Pro Ala Trp Gly 
1               5                   10                  15      


Gln Leu His Thr Gln Pro Glu Val Glu Pro Gln Val Asp Ser Pro Ala 
            20                  25                  30          


Pro Pro Arg Pro Ser Leu Gln Pro His Pro Arg Leu Leu Asp His Arg 
        35                  40                  45              


Asp Ser Val Glu Gln Val Ala Val Leu Ala Ser Leu Gly Ile Leu Ser 
    50                  55                  60                  


Phe Leu Gly Leu Val Ala Gly Ala Leu Ala Leu Gly Leu 
65                  70                  75          


<210>  6865
<211>  328
<212>  PRT
<213>  Homo Sapiens

<400>  6865

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser 
                325             


<210>  6866
<211>  51
<212>  PRT
<213>  Homo Sapiens

<400>  6866

Met Glu Pro Leu Val Thr Trp Val Val Pro Leu Leu Phe Leu Phe Leu 
1               5                   10                  15      


Leu Ser Arg Gln Gly Ala Ala Cys Arg Thr Ser Glu Cys Cys Phe Gln 
            20                  25                  30          


Asp Pro Pro Tyr Pro Asp Ala Asp Ser Gly Ser Ala Ser Gly Pro Arg 
        35                  40                  45              


Asp Leu Arg 
    50      


<210>  6867
<211>  67
<212>  PRT
<213>  Homo Sapiens

<400>  6867

Met Glu Pro Leu Val Thr Trp Val Val Pro Leu Leu Phe Leu Phe Leu 
1               5                   10                  15      


Leu Ser Arg Gln Gly Ala Ala Cys Arg Thr Ser Glu Cys Cys Phe Gln 
            20                  25                  30          


Asp Pro Pro Tyr Pro Asp Ala Asp Ser Gly Ser Ala Ser Gly Pro Arg 
        35                  40                  45              


Asp Leu Arg Cys Tyr Arg Ile Ser Ser Asp Arg Tyr Glu Cys Ser Trp 
    50                  55                  60                  


Gln Tyr Glu 
65          


<210>  6868
<211>  381
<212>  PRT
<213>  Homo Sapiens

<400>  6868

Met Glu Pro Leu Val Thr Trp Val Val Pro Leu Leu Phe Leu Phe Leu 
1               5                   10                  15      


Leu Ser Arg Gln Gly Ala Ala Cys Arg Thr Ser Glu Cys Cys Phe Gln 
            20                  25                  30          


Asp Pro Pro Tyr Pro Asp Ala Asp Ser Gly Ser Ala Ser Gly Pro Arg 
        35                  40                  45              


Asp Leu Arg Cys Tyr Arg Ile Ser Ser Asp Arg Tyr Glu Cys Ser Trp 
    50                  55                  60                  


Gln Tyr Glu Gly Pro Thr Ala Gly Val Ser His Phe Leu Arg Cys Cys 
65                  70                  75                  80  


Leu Ser Ser Gly Arg Cys Cys Tyr Phe Ala Ala Gly Ser Ala Thr Arg 
                85                  90                  95      


Leu Gln Phe Ser Asp Gln Ala Gly Val Ser Val Leu Tyr Thr Val Thr 
            100                 105                 110         


Leu Trp Val Glu Ser Trp Ala Arg Asn Gln Thr Glu Lys Ser Pro Glu 
        115                 120                 125             


Val Thr Leu Gln Leu Tyr Asn Ser Val Lys Tyr Glu Pro Pro Leu Gly 
    130                 135                 140                 


Asp Ile Lys Val Ser Lys Leu Ala Gly Gln Leu Arg Met Glu Trp Glu 
145                 150                 155                 160 


Thr Pro Asp Asn Gln Val Gly Ala Glu Val Gln Phe Arg His Arg Thr 
                165                 170                 175     


Pro Ser Ser Pro Trp Lys Leu Gly Asp Cys Gly Pro Gln Asp Asp Asp 
            180                 185                 190         


Thr Glu Ser Cys Leu Cys Pro Leu Glu Met Asn Val Ala Gln Glu Phe 
        195                 200                 205             


Gln Leu Arg Arg Arg Gln Leu Gly Ser Gln Gly Ser Ser Trp Ser Lys 
    210                 215                 220                 


Trp Ser Ser Pro Val Cys Val Pro Pro Glu Asn Pro Pro Gln Pro Gln 
225                 230                 235                 240 


Val Arg Phe Ser Val Glu Gln Leu Gly Gln Asp Gly Arg Arg Arg Leu 
                245                 250                 255     


Thr Leu Lys Glu Gln Pro Thr Gln Leu Glu Leu Pro Glu Gly Cys Gln 
            260                 265                 270         


Gly Leu Ala Pro Gly Thr Glu Val Thr Tyr Arg Leu Gln Leu His Met 
        275                 280                 285             


Leu Ser Cys Pro Cys Lys Ala Lys Ala Thr Arg Thr Leu His Leu Gly 
    290                 295                 300                 


Lys Met Pro Tyr Leu Ser Gly Ala Ala Tyr Asn Val Ala Val Ile Ser 
305                 310                 315                 320 


Ser Asn Gln Phe Gly Pro Gly Leu Asn Gln Thr Trp His Ile Pro Ala 
                325                 330                 335     


Asp Thr His Thr Asp Gly Met Ile Ser Ala His Cys Asn Leu Arg Leu 
            340                 345                 350         


Pro Asp Ser Arg Asp Ser Pro Ala Ser Ala Ser Arg Val Ala Gly Ile 
        355                 360                 365             


Thr Gly Ile Cys His His Thr Arg Leu Ile Leu Tyr Phe 
    370                 375                 380     


<210>  6869
<211>  662
<212>  PRT
<213>  Homo Sapiens

<400>  6869

Met Glu Pro Leu Val Thr Trp Val Val Pro Leu Leu Phe Leu Phe Leu 
1               5                   10                  15      


Leu Ser Arg Gln Gly Ala Ala Cys Arg Thr Ser Glu Cys Cys Phe Gln 
            20                  25                  30          


Asp Pro Pro Tyr Pro Asp Ala Asp Ser Gly Ser Ala Ser Gly Pro Arg 
        35                  40                  45              


Asp Leu Arg Cys Tyr Arg Ile Ser Ser Asp Arg Tyr Glu Cys Ser Trp 
    50                  55                  60                  


Gln Tyr Glu Gly Pro Thr Ala Gly Val Ser His Phe Leu Arg Cys Cys 
65                  70                  75                  80  


Leu Ser Ser Gly Arg Cys Cys Tyr Phe Ala Ala Gly Ser Ala Thr Arg 
                85                  90                  95      


Leu Gln Phe Ser Asp Gln Ala Gly Val Ser Val Leu Tyr Thr Val Thr 
            100                 105                 110         


Leu Trp Val Glu Ser Trp Ala Arg Asn Gln Thr Glu Lys Ser Pro Glu 
        115                 120                 125             


Val Thr Leu Gln Leu Tyr Asn Ser Val Lys Tyr Glu Pro Pro Leu Gly 
    130                 135                 140                 


Asp Ile Lys Val Ser Lys Leu Ala Gly Gln Leu Arg Met Glu Trp Glu 
145                 150                 155                 160 


Thr Pro Asp Asn Gln Val Gly Ala Glu Val Gln Phe Arg His Arg Thr 
                165                 170                 175     


Pro Ser Ser Pro Trp Lys Leu Gly Asp Cys Gly Pro Gln Asp Asp Asp 
            180                 185                 190         


Thr Glu Ser Cys Leu Cys Pro Leu Glu Met Asn Val Ala Gln Glu Phe 
        195                 200                 205             


Gln Leu Arg Arg Arg Gln Leu Gly Ser Gln Gly Ser Ser Trp Ser Lys 
    210                 215                 220                 


Trp Ser Ser Pro Val Cys Val Pro Pro Glu Asn Pro Pro Gln Pro Gln 
225                 230                 235                 240 


Val Arg Phe Ser Val Glu Gln Leu Gly Gln Asp Gly Arg Arg Arg Leu 
                245                 250                 255     


Thr Leu Lys Glu Gln Pro Thr Gln Leu Glu Leu Pro Glu Gly Cys Gln 
            260                 265                 270         


Gly Leu Ala Pro Gly Thr Glu Val Thr Tyr Arg Leu Gln Leu His Met 
        275                 280                 285             


Leu Ser Cys Pro Cys Lys Ala Lys Ala Thr Arg Thr Leu His Leu Gly 
    290                 295                 300                 


Lys Met Pro Tyr Leu Ser Gly Ala Ala Tyr Asn Val Ala Val Ile Ser 
305                 310                 315                 320 


Ser Asn Gln Phe Gly Pro Gly Leu Asn Gln Thr Trp His Ile Pro Ala 
                325                 330                 335     


Asp Thr His Thr Glu Pro Val Ala Leu Asn Ile Ser Val Gly Thr Asn 
            340                 345                 350         


Gly Thr Thr Met Tyr Trp Pro Ala Arg Ala Gln Ser Met Thr Tyr Cys 
        355                 360                 365             


Ile Glu Trp Gln Pro Val Gly Gln Asp Gly Gly Leu Ala Thr Cys Ser 
    370                 375                 380                 


Leu Thr Ala Pro Gln Asp Pro Asp Pro Ala Gly Met Ala Thr Tyr Ser 
385                 390                 395                 400 


Trp Ser Arg Glu Ser Gly Ala Met Gly Gln Glu Lys Cys Tyr Tyr Ile 
                405                 410                 415     


Thr Ile Phe Ala Ser Ala His Pro Glu Lys Leu Thr Leu Trp Ser Thr 
            420                 425                 430         


Val Leu Ser Thr Tyr His Phe Gly Gly Asn Ala Ser Ala Ala Gly Thr 
        435                 440                 445             


Pro His His Val Ser Val Lys Asn His Ser Leu Asp Ser Val Ser Val 
    450                 455                 460                 


Asp Trp Ala Pro Ser Leu Leu Ser Thr Cys Pro Gly Val Leu Lys Glu 
465                 470                 475                 480 


Tyr Val Val Arg Cys Arg Asp Glu Asp Ser Lys Gln Val Ser Glu His 
                485                 490                 495     


Pro Val Gln Pro Thr Glu Thr Gln Val Thr Leu Ser Gly Leu Arg Ala 
            500                 505                 510         


Gly Val Ala Tyr Thr Val Gln Val Arg Ala Asp Thr Ala Trp Leu Arg 
        515                 520                 525             


Gly Val Trp Ser Gln Pro Gln Arg Phe Ser Ile Glu Val Gln Val Ser 
    530                 535                 540                 


Asp Trp Leu Ile Phe Phe Ala Ser Leu Gly Ser Phe Leu Ser Ile Leu 
545                 550                 555                 560 


Leu Val Gly Val Leu Gly Tyr Leu Gly Leu Asn Arg Ala Ala Arg His 
                565                 570                 575     


Leu Cys Pro Pro Leu Pro Thr Pro Cys Ala Ser Ser Ala Ile Glu Phe 
            580                 585                 590         


Pro Gly Gly Lys Glu Thr Trp Gln Trp Ile Asn Pro Val Asp Phe Gln 
        595                 600                 605             


Glu Glu Ala Ser Leu Gln Glu Ala Leu Val Val Glu Met Ser Trp Asp 
    610                 615                 620                 


Lys Gly Glu Arg Thr Glu Pro Leu Glu Lys Thr Glu Leu Pro Glu Gly 
625                 630                 635                 640 


Ala Pro Glu Leu Ala Leu Asp Thr Glu Leu Ser Leu Glu Asp Gly Asp 
                645                 650                 655     


Arg Cys Lys Ala Lys Met 
            660         


<210>  6870
<211>  662
<212>  PRT
<213>  Homo Sapiens

<400>  6870

Met Glu Pro Leu Val Thr Trp Val Val Pro Leu Leu Phe Leu Phe Leu 
1               5                   10                  15      


Leu Ser Arg Gln Gly Ala Ala Cys Arg Thr Ser Glu Cys Cys Phe Gln 
            20                  25                  30          


Asp Pro Pro Tyr Pro Asp Ala Asp Ser Gly Ser Ala Ser Gly Pro Arg 
        35                  40                  45              


Asp Leu Arg Cys Tyr Arg Ile Ser Ser Asp Arg Tyr Glu Cys Ser Trp 
    50                  55                  60                  


Gln Tyr Glu Gly Pro Thr Ala Gly Val Ser His Phe Leu Arg Cys Cys 
65                  70                  75                  80  


Leu Ser Ser Gly Arg Cys Cys Tyr Phe Ala Ala Gly Ser Ala Thr Arg 
                85                  90                  95      


Leu Gln Phe Ser Asp Gln Ala Gly Val Ser Val Leu Tyr Thr Val Thr 
            100                 105                 110         


Leu Trp Val Glu Ser Trp Ala Arg Asn Gln Thr Glu Lys Ser Pro Glu 
        115                 120                 125             


Val Thr Leu Gln Leu Tyr Asn Ser Val Lys Tyr Glu Pro Pro Leu Gly 
    130                 135                 140                 


Asp Ile Lys Val Ser Lys Leu Ala Gly Gln Leu Arg Met Glu Trp Glu 
145                 150                 155                 160 


Thr Pro Asp Asn Gln Val Gly Ala Glu Val Gln Phe Arg His Arg Thr 
                165                 170                 175     


Pro Ser Ser Pro Trp Lys Leu Gly Asp Cys Gly Pro Gln Asp Asp Asp 
            180                 185                 190         


Thr Glu Ser Cys Leu Cys Pro Leu Glu Met Asn Val Ala Gln Glu Phe 
        195                 200                 205             


Gln Leu Arg Arg Arg Gln Leu Gly Ser Gln Gly Ser Ser Trp Ser Lys 
    210                 215                 220                 


Trp Ser Ser Pro Val Cys Val Pro Pro Glu Asn Pro Pro Gln Pro Gln 
225                 230                 235                 240 


Val Arg Phe Ser Val Glu Gln Leu Gly Gln Asp Gly Arg Arg Arg Leu 
                245                 250                 255     


Thr Leu Lys Glu Gln Pro Thr Gln Leu Glu Leu Pro Glu Gly Cys Gln 
            260                 265                 270         


Gly Leu Ala Pro Gly Thr Glu Val Thr Tyr Arg Leu Gln Leu His Met 
        275                 280                 285             


Leu Ser Cys Pro Cys Lys Ala Lys Ala Thr Arg Thr Leu His Leu Gly 
    290                 295                 300                 


Lys Met Pro Tyr Leu Ser Gly Ala Ala Tyr Asn Val Ala Val Ile Ser 
305                 310                 315                 320 


Ser Asn Gln Phe Gly Pro Gly Leu Asn Gln Thr Trp His Ile Pro Ala 
                325                 330                 335     


Asp Thr His Thr Glu Pro Val Ala Leu Asn Ile Ser Val Gly Thr Asn 
            340                 345                 350         


Gly Thr Thr Met Tyr Trp Pro Ala Arg Ala Gln Ser Met Thr Tyr Cys 
        355                 360                 365             


Ile Glu Trp Gln Pro Val Gly Gln Asp Gly Gly Leu Ala Thr Cys Ser 
    370                 375                 380                 


Leu Thr Ala Pro Gln Asp Pro Asp Pro Ala Gly Met Ala Thr Tyr Ser 
385                 390                 395                 400 


Trp Ser Arg Glu Ser Gly Ala Met Gly Gln Glu Lys Cys Tyr Tyr Ile 
                405                 410                 415     


Thr Ile Phe Ala Ser Ala His Pro Glu Lys Leu Thr Leu Trp Ser Thr 
            420                 425                 430         


Val Leu Ser Thr Tyr His Phe Gly Gly Asn Ala Ser Ala Ala Gly Thr 
        435                 440                 445             


Pro His His Val Ser Val Lys Asn His Ser Leu Asp Ser Val Ser Val 
    450                 455                 460                 


Asp Trp Ala Pro Ser Leu Leu Ser Thr Cys Pro Gly Val Leu Lys Glu 
465                 470                 475                 480 


Tyr Val Val Arg Cys Arg Asp Glu Asp Ser Lys Gln Val Ser Glu His 
                485                 490                 495     


Pro Val Gln Pro Thr Glu Thr Gln Val Thr Leu Ser Gly Leu Arg Ala 
            500                 505                 510         


Gly Val Ala Tyr Thr Val Gln Val Arg Ala Asp Thr Ala Trp Leu Arg 
        515                 520                 525             


Gly Val Trp Ser Gln Pro Gln Arg Phe Ser Ile Glu Val Gln Val Ser 
    530                 535                 540                 


Asp Trp Leu Ile Phe Phe Ala Ser Leu Gly Ser Phe Leu Ser Ile Leu 
545                 550                 555                 560 


Leu Val Gly Val Leu Gly Tyr Leu Gly Leu Asn Arg Ala Ala Arg His 
                565                 570                 575     


Leu Cys Pro Pro Leu Pro Thr Pro Cys Ala Ser Ser Ala Ile Glu Phe 
            580                 585                 590         


Pro Gly Gly Lys Glu Thr Trp Gln Trp Ile Asn Pro Val Asp Phe Gln 
        595                 600                 605             


Glu Glu Ala Ser Leu Gln Glu Ala Leu Val Val Glu Met Ser Trp Asp 
    610                 615                 620                 


Lys Gly Glu Arg Thr Glu Pro Leu Glu Lys Thr Glu Leu Pro Glu Gly 
625                 630                 635                 640 


Ala Pro Glu Leu Ala Leu Asp Thr Glu Leu Ser Leu Glu Asp Gly Asp 
                645                 650                 655     


Arg Cys Lys Ala Lys Met 
            660         


<210>  6871
<211>  118
<212>  PRT
<213>  Homo Sapiens

<400>  6871

Met Glu Pro Leu Val Thr Trp Val Val Pro Leu Leu Phe Leu Phe Leu 
1               5                   10                  15      


Leu Ser Arg Gln Gly Ala Ala Cys Arg Thr Ser Glu Cys Cys Phe Gln 
            20                  25                  30          


Asp Pro Pro Tyr Pro Asp Ala Asp Ser Gly Ser Leu Pro Gly Ser Ala 
        35                  40                  45              


Ser Gly Pro Arg Asp Leu Arg Cys Tyr Arg Ile Ser Ser Asp Arg Tyr 
    50                  55                  60                  


Glu Cys Ser Trp Gln Tyr Glu Gly Pro Thr Ala Gly Val Ser His Phe 
65                  70                  75                  80  


Leu Arg Cys Cys Leu Ser Ser Gly Arg Cys Cys Tyr Phe Ala Ala Gly 
                85                  90                  95      


Ser Ala Thr Arg Leu Gln Phe Ser Asp Gln Ala Gly Val Ser Val Leu 
            100                 105                 110         


Tyr Thr Val Thr Leu Trp 
        115             


<210>  6872
<211>  862
<212>  PRT
<213>  Homo Sapiens

<400>  6872

Met Ala His Thr Phe Arg Gly Cys Ser Leu Ala Phe Met Phe Ile Ile 
1               5                   10                  15      


Thr Trp Leu Leu Ile Lys Ala Lys Ile Asp Ala Cys Lys Arg Gly Asp 
            20                  25                  30          


Val Thr Val Lys Pro Ser His Val Ile Leu Leu Gly Ser Thr Val Asn 
        35                  40                  45              


Ile Thr Cys Ser Leu Lys Pro Arg Gln Gly Cys Phe His Tyr Ser Arg 
    50                  55                  60                  


Arg Asn Lys Leu Ile Leu Tyr Lys Phe Asp Arg Arg Ile Asn Phe His 
65                  70                  75                  80  


His Gly His Ser Leu Asn Ser Gln Val Thr Gly Leu Pro Leu Gly Thr 
                85                  90                  95      


Thr Leu Phe Val Cys Lys Leu Ala Cys Ile Asn Ser Asp Glu Ile Gln 
            100                 105                 110         


Ile Cys Gly Ala Glu Ile Phe Val Gly Val Ala Pro Glu Gln Pro Gln 
        115                 120                 125             


Asn Leu Ser Cys Ile Gln Lys Gly Glu Gln Gly Thr Val Ala Cys Thr 
    130                 135                 140                 


Trp Glu Arg Gly Arg Asp Thr His Leu Tyr Thr Glu Tyr Thr Leu Gln 
145                 150                 155                 160 


Leu Ser Gly Pro Lys Asn Leu Thr Trp Gln Lys Gln Cys Lys Asp Ile 
                165                 170                 175     


Tyr Cys Asp Tyr Leu Asp Phe Gly Ile Asn Leu Thr Pro Glu Ser Pro 
            180                 185                 190         


Glu Ser Asn Phe Thr Ala Lys Val Thr Ala Val Asn Ser Leu Gly Ser 
        195                 200                 205             


Ser Ser Ser Leu Pro Ser Thr Phe Thr Phe Leu Asp Ile Val Arg Pro 
    210                 215                 220                 


Leu Pro Pro Trp Asp Ile Arg Ile Lys Phe Gln Lys Ala Ser Val Ser 
225                 230                 235                 240 


Arg Cys Thr Leu Tyr Trp Arg Asp Glu Gly Leu Val Leu Leu Asn Arg 
                245                 250                 255     


Leu Arg Tyr Arg Pro Ser Asn Ser Arg Leu Trp Asn Met Val Asn Val 
            260                 265                 270         


Thr Lys Ala Lys Gly Arg His Asp Leu Leu Asp Leu Lys Pro Phe Thr 
        275                 280                 285             


Glu Tyr Glu Phe Gln Ile Ser Ser Lys Leu His Leu Tyr Lys Gly Ser 
    290                 295                 300                 


Trp Ser Asp Trp Ser Glu Ser Leu Arg Ala Gln Thr Pro Glu Glu Glu 
305                 310                 315                 320 


Pro Thr Gly Met Leu Asp Val Trp Tyr Met Lys Arg His Ile Asp Tyr 
                325                 330                 335     


Ser Arg Gln Gln Ile Ser Leu Phe Trp Lys Asn Leu Ser Val Ser Glu 
            340                 345                 350         


Ala Arg Gly Lys Ile Leu His Tyr Gln Val Thr Leu Gln Glu Leu Thr 
        355                 360                 365             


Gly Gly Lys Ala Met Thr Gln Asn Ile Thr Gly His Thr Ser Trp Thr 
    370                 375                 380                 


Thr Val Ile Pro Arg Thr Gly Asn Trp Ala Val Ala Val Ser Ala Ala 
385                 390                 395                 400 


Asn Ser Lys Gly Ser Ser Leu Pro Thr Arg Ile Asn Ile Met Asn Leu 
                405                 410                 415     


Cys Glu Ala Gly Leu Leu Ala Pro Arg Gln Val Ser Ala Asn Ser Glu 
            420                 425                 430         


Gly Met Asp Asn Ile Leu Val Thr Trp Gln Pro Pro Arg Lys Asp Pro 
        435                 440                 445             


Ser Ala Val Gln Glu Tyr Val Val Glu Trp Arg Glu Leu His Pro Gly 
    450                 455                 460                 


Gly Asp Thr Gln Val Pro Leu Asn Trp Leu Arg Ser Arg Pro Tyr Asn 
465                 470                 475                 480 


Val Ser Ala Leu Ile Ser Glu Asn Ile Lys Ser Tyr Ile Cys Tyr Glu 
                485                 490                 495     


Ile Arg Val Tyr Ala Leu Ser Gly Asp Gln Gly Gly Cys Ser Ser Ile 
            500                 505                 510         


Leu Gly Asn Ser Lys His Lys Ala Pro Leu Ser Gly Pro His Ile Asn 
        515                 520                 525             


Ala Ile Thr Glu Glu Lys Gly Ser Ile Leu Ile Ser Trp Asn Ser Ile 
    530                 535                 540                 


Pro Val Gln Glu Gln Met Gly Cys Leu Leu His Tyr Arg Ile Tyr Trp 
545                 550                 555                 560 


Lys Glu Arg Asp Ser Asn Ser Gln Pro Gln Leu Cys Glu Ile Pro Tyr 
                565                 570                 575     


Arg Val Ser Gln Asn Ser His Pro Ile Asn Ser Leu Gln Pro Arg Val 
            580                 585                 590         


Thr Tyr Val Leu Trp Met Thr Ala Leu Thr Ala Ala Gly Glu Ser Ser 
        595                 600                 605             


His Gly Asn Glu Arg Glu Phe Cys Leu Gln Gly Lys Ala Asn Trp Met 
    610                 615                 620                 


Ala Phe Val Ala Pro Ser Ile Cys Ile Ala Ile Ile Met Val Gly Ile 
625                 630                 635                 640 


Phe Ser Thr His Tyr Phe Gln Gln Lys Val Phe Val Leu Leu Ala Ala 
                645                 650                 655     


Leu Arg Pro Gln Trp Cys Ser Arg Glu Ile Pro Asp Pro Ala Asn Ser 
            660                 665                 670         


Thr Cys Ala Lys Lys Tyr Pro Ile Ala Glu Glu Lys Thr Gln Leu Pro 
        675                 680                 685             


Leu Asp Arg Leu Leu Ile Asp Trp Pro Thr Pro Glu Asp Pro Glu Pro 
    690                 695                 700                 


Leu Val Ile Ser Glu Val Leu His Gln Val Thr Pro Val Phe Arg His 
705                 710                 715                 720 


Pro Pro Cys Ser Asn Trp Pro Gln Arg Glu Lys Gly Ile Gln Gly His 
                725                 730                 735     


Gln Ala Ser Glu Lys Asp Met Met His Ser Ala Ser Ser Pro Pro Pro 
            740                 745                 750         


Pro Arg Ala Leu Gln Ala Glu Ser Arg Gln Leu Val Asp Leu Tyr Lys 
        755                 760                 765             


Val Leu Glu Ser Arg Gly Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys 
    770                 775                 780                 


Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr 
785                 790                 795                 800 


Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala 
                805                 810                 815     


Asp Ser Leu Glu Glu Leu Glu Pro Gln His Ile Ser Leu Ser Val Phe 
            820                 825                 830         


Pro Ser Ser Ser Leu His Pro Leu Thr Phe Ser Cys Gly Asp Lys Leu 
        835                 840                 845             


Thr Leu Asp Gln Leu Lys Met Arg Cys Asp Ser Leu Met Leu 
    850                 855                 860         


<210>  6873
<211>  659
<212>  PRT
<213>  Homo Sapiens

<400>  6873

Met Ala His Thr Phe Arg Gly Cys Ser Leu Ala Phe Met Phe Ile Ile 
1               5                   10                  15      


Thr Trp Leu Leu Ile Lys Ala Lys Ile Asp Ala Cys Lys Arg Gly Asp 
            20                  25                  30          


Val Thr Val Lys Pro Ser His Val Ile Leu Leu Gly Ser Thr Val Asn 
        35                  40                  45              


Ile Thr Cys Ser Leu Lys Pro Arg Gln Gly Cys Phe His Tyr Ser Arg 
    50                  55                  60                  


Arg Asn Lys Leu Ile Leu Tyr Lys Phe Asp Arg Arg Ile Asn Phe His 
65                  70                  75                  80  


His Gly His Ser Leu Asn Ser Gln Val Thr Gly Leu Pro Leu Gly Thr 
                85                  90                  95      


Thr Leu Phe Val Cys Lys Leu Ala Cys Ile Asn Ser Asp Glu Ile Gln 
            100                 105                 110         


Ile Cys Gly Ala Glu Ile Phe Val Gly Val Ala Pro Glu Gln Pro Gln 
        115                 120                 125             


Asn Leu Ser Cys Ile Gln Lys Gly Glu Gln Gly Thr Val Ala Cys Thr 
    130                 135                 140                 


Trp Glu Arg Gly Arg Asp Thr His Leu Tyr Thr Glu Tyr Thr Leu Gln 
145                 150                 155                 160 


Leu Ser Gly Pro Lys Asn Leu Thr Trp Gln Lys Gln Cys Lys Asp Ile 
                165                 170                 175     


Tyr Cys Asp Tyr Leu Asp Phe Gly Ile Asn Leu Thr Pro Glu Ser Pro 
            180                 185                 190         


Glu Ser Asn Phe Thr Ala Lys Val Thr Ala Val Asn Ser Leu Gly Ser 
        195                 200                 205             


Ser Ser Ser Leu Pro Ser Thr Phe Thr Phe Leu Asp Ile Val Arg Pro 
    210                 215                 220                 


Leu Pro Pro Trp Asp Ile Arg Ile Lys Phe Gln Lys Ala Ser Val Ser 
225                 230                 235                 240 


Arg Cys Thr Leu Tyr Trp Arg Asp Glu Gly Leu Val Leu Leu Asn Arg 
                245                 250                 255     


Leu Arg Tyr Arg Pro Ser Asn Ser Arg Leu Trp Asn Met Val Asn Val 
            260                 265                 270         


Thr Lys Ala Lys Gly Arg His Asp Leu Leu Asp Leu Lys Pro Phe Thr 
        275                 280                 285             


Glu Tyr Glu Phe Gln Ile Ser Ser Lys Leu His Leu Tyr Lys Gly Ser 
    290                 295                 300                 


Trp Ser Asp Trp Ser Glu Ser Leu Arg Ala Gln Thr Pro Glu Glu Glu 
305                 310                 315                 320 


Pro Thr Gly Met Leu Asp Val Trp Tyr Met Lys Arg His Ile Asp Tyr 
                325                 330                 335     


Ser Arg Gln Gln Ile Ser Leu Phe Trp Lys Asn Leu Ser Val Ser Glu 
            340                 345                 350         


Ala Arg Gly Lys Ile Leu His Tyr Gln Val Thr Leu Gln Glu Leu Thr 
        355                 360                 365             


Gly Gly Lys Ala Met Thr Gln Asn Ile Thr Gly His Thr Ser Trp Thr 
    370                 375                 380                 


Thr Val Ile Pro Arg Thr Gly Asn Trp Ala Val Ala Val Ser Ala Ala 
385                 390                 395                 400 


Asn Ser Lys Gly Ser Ser Leu Pro Thr Arg Ile Asn Ile Met Asn Leu 
                405                 410                 415     


Cys Glu Ala Gly Leu Leu Ala Pro Arg Gln Val Ser Ala Asn Ser Glu 
            420                 425                 430         


Gly Met Asp Asn Ile Leu Val Thr Trp Gln Pro Pro Arg Lys Asp Pro 
        435                 440                 445             


Ser Ala Val Gln Glu Tyr Val Val Glu Trp Arg Glu Leu His Pro Gly 
    450                 455                 460                 


Gly Asp Thr Gln Val Pro Leu Asn Trp Leu Arg Ser Arg Pro Tyr Asn 
465                 470                 475                 480 


Val Ser Ala Leu Ile Ser Glu Asn Ile Lys Ser Tyr Ile Cys Tyr Glu 
                485                 490                 495     


Ile Arg Val Tyr Ala Leu Ser Gly Asp Gln Gly Gly Cys Ser Ser Ile 
            500                 505                 510         


Leu Gly Asn Ser Lys His Lys Ala Pro Leu Ser Gly Pro His Ile Asn 
        515                 520                 525             


Ala Ile Thr Glu Glu Lys Gly Ser Ile Leu Ile Ser Trp Asn Ser Ile 
    530                 535                 540                 


Pro Val Gln Glu Gln Met Gly Cys Leu Leu His Tyr Arg Ile Tyr Trp 
545                 550                 555                 560 


Lys Glu Arg Asp Ser Asn Ser Gln Pro Gln Leu Cys Glu Ile Pro Tyr 
                565                 570                 575     


Arg Val Ser Gln Asn Ser His Pro Ile Asn Ser Leu Gln Pro Arg Val 
            580                 585                 590         


Thr Tyr Val Leu Trp Met Thr Ala Leu Thr Ala Ala Gly Glu Ser Ser 
        595                 600                 605             


His Gly Asn Glu Arg Glu Phe Cys Leu Gln Gly Lys Ala Asn Trp Met 
    610                 615                 620                 


Ala Phe Val Ala Pro Ser Ile Cys Ile Ala Ile Ile Met Val Gly Ile 
625                 630                 635                 640 


Phe Ser Thr His Tyr Phe Gln Gln Lys Arg Arg His Ser Cys Pro Trp 
                645                 650                 655     


Thr Gly Ser 
            


<210>  6874
<211>  635
<212>  PRT
<213>  Homo Sapiens

<400>  6874

Met Ala His Thr Phe Arg Gly Cys Ser Leu Ala Phe Met Phe Ile Ile 
1               5                   10                  15      


Thr Trp Leu Leu Ile Lys Ala Lys Ile Asp Ala Cys Lys Arg Gly Asp 
            20                  25                  30          


Val Thr Val Lys Pro Ser His Val Ile Leu Leu Gly Ser Thr Val Asn 
        35                  40                  45              


Ile Thr Cys Ser Leu Lys Pro Arg Gln Gly Cys Phe His Tyr Ser Arg 
    50                  55                  60                  


Arg Asn Lys Leu Ile Leu Tyr Lys Phe Asp Arg Arg Ile Asn Phe His 
65                  70                  75                  80  


His Gly His Ser Leu Asn Ser Gln Val Thr Gly Leu Pro Leu Gly Thr 
                85                  90                  95      


Thr Leu Phe Val Cys Lys Leu Ala Cys Ile Asn Ser Asp Glu Ile Gln 
            100                 105                 110         


Ile Cys Gly Ala Glu Ile Phe Val Gly Val Ala Pro Glu Gln Pro Gln 
        115                 120                 125             


Asn Leu Ser Cys Ile Gln Lys Gly Glu Gln Gly Thr Val Ala Cys Thr 
    130                 135                 140                 


Trp Glu Arg Gly Arg Asp Thr His Leu Tyr Thr Glu Tyr Thr Leu Gln 
145                 150                 155                 160 


Leu Ser Gly Pro Lys Asn Leu Thr Trp Gln Lys Gln Cys Lys Asp Ile 
                165                 170                 175     


Tyr Cys Asp Tyr Leu Asp Phe Gly Ile Asn Leu Thr Pro Glu Ser Pro 
            180                 185                 190         


Glu Ser Asn Phe Thr Ala Lys Val Thr Ala Val Asn Ser Leu Gly Ser 
        195                 200                 205             


Ser Ser Ser Leu Pro Ser Thr Phe Thr Phe Leu Asp Ile Val Arg Pro 
    210                 215                 220                 


Leu Pro Pro Trp Asp Ile Arg Ile Lys Phe Gln Lys Ala Ser Val Ser 
225                 230                 235                 240 


Arg Cys Thr Leu Tyr Trp Arg Asp Glu Gly Leu Val Leu Leu Asn Arg 
                245                 250                 255     


Leu Arg Tyr Arg Pro Ser Asn Ser Arg Leu Trp Asn Met Val Asn Val 
            260                 265                 270         


Thr Lys Ala Lys Gly Arg His Asp Leu Leu Asp Leu Lys Pro Phe Thr 
        275                 280                 285             


Glu Tyr Glu Phe Gln Ile Ser Ser Lys Leu His Leu Tyr Lys Gly Ser 
    290                 295                 300                 


Trp Ser Asp Trp Ser Glu Ser Leu Arg Ala Gln Thr Pro Glu Glu Glu 
305                 310                 315                 320 


Pro Thr Gly Met Leu Asp Val Trp Tyr Met Lys Arg His Ile Asp Tyr 
                325                 330                 335     


Ser Arg Gln Gln Ile Ser Leu Phe Trp Lys Asn Leu Ser Val Ser Glu 
            340                 345                 350         


Ala Arg Gly Lys Ile Leu His Tyr Gln Val Thr Leu Gln Glu Leu Thr 
        355                 360                 365             


Gly Gly Lys Ala Met Thr Gln Asn Ile Thr Gly His Thr Ser Trp Thr 
    370                 375                 380                 


Thr Val Ile Pro Arg Thr Gly Asn Trp Ala Val Ala Val Ser Ala Ala 
385                 390                 395                 400 


Asn Ser Lys Gly Ser Ser Leu Pro Thr Arg Ile Asn Ile Met Asn Leu 
                405                 410                 415     


Cys Glu Ala Gly Leu Leu Ala Pro Arg Gln Val Ser Ala Asn Ser Glu 
            420                 425                 430         


Gly Met Asp Asn Ile Leu Val Thr Trp Gln Pro Pro Arg Lys Asp Pro 
        435                 440                 445             


Ser Ala Val Gln Glu Tyr Val Val Glu Trp Arg Glu Leu His Pro Gly 
    450                 455                 460                 


Gly Asp Thr Gln Val Pro Leu Asn Trp Leu Arg Ser Arg Pro Tyr Asn 
465                 470                 475                 480 


Val Ser Ala Leu Ile Ser Glu Asn Ile Lys Ser Tyr Ile Cys Tyr Glu 
                485                 490                 495     


Ile Arg Val Tyr Ala Leu Ser Gly Asp Gln Gly Gly Cys Ser Ser Ile 
            500                 505                 510         


Leu Gly Asn Ser Lys His Lys Ala Pro Leu Ser Gly Pro His Ile Asn 
        515                 520                 525             


Ala Ile Thr Glu Glu Lys Gly Ser Ile Leu Ile Ser Trp Asn Ser Ile 
    530                 535                 540                 


Pro Val Gln Glu Gln Met Gly Cys Leu Leu His Tyr Arg Ile Tyr Trp 
545                 550                 555                 560 


Lys Glu Arg Asp Ser Asn Ser Gln Pro Gln Leu Cys Glu Ile Pro Tyr 
                565                 570                 575     


Arg Val Ser Gln Asn Ser His Pro Ile Asn Ser Leu Gln Pro Arg Val 
            580                 585                 590         


Thr Tyr Val Leu Trp Met Thr Ala Leu Thr Ala Ala Gly Glu Ser Ser 
        595                 600                 605             


His Gly Asn Glu Arg Glu Phe Cys Leu Gln Gly Glu Asp Thr Ala Ala 
    610                 615                 620                 


Leu Gly Gln Ala Pro Asp Arg Leu Ala His Ala 
625                 630                 635 


<210>  6875
<211>  776
<212>  PRT
<213>  Homo Sapiens

<400>  6875

Met Ala His Thr Phe Arg Gly Cys Ser Leu Ala Phe Met Phe Ile Ile 
1               5                   10                  15      


Thr Trp Leu Leu Ile Lys Ala Lys Ile Asp Ala Cys Lys Arg Gly Asp 
            20                  25                  30          


Val Thr Val Lys Pro Ser His Val Ile Leu Leu Gly Ser Thr Val Asn 
        35                  40                  45              


Ile Thr Cys Ser Leu Lys Pro Arg Gln Gly Cys Phe His Tyr Ser Arg 
    50                  55                  60                  


Arg Asn Lys Leu Ile Leu Tyr Lys Phe Asp Arg Arg Ile Asn Phe His 
65                  70                  75                  80  


His Gly His Ser Leu Asn Ser Gln Val Thr Gly Leu Pro Leu Gly Thr 
                85                  90                  95      


Thr Leu Phe Val Cys Lys Leu Ala Cys Ile Asn Ser Asp Glu Ile Gln 
            100                 105                 110         


Ile Cys Gly Ala Glu Ile Phe Val Gly Val Ala Pro Glu Gln Pro Gln 
        115                 120                 125             


Asn Leu Ser Cys Ile Gln Lys Gly Glu Gln Gly Thr Val Ala Cys Thr 
    130                 135                 140                 


Trp Glu Arg Gly Arg Asp Thr His Leu Tyr Thr Glu Tyr Thr Leu Gln 
145                 150                 155                 160 


Leu Ser Gly Pro Lys Asn Leu Thr Trp Gln Lys Gln Cys Lys Asp Ile 
                165                 170                 175     


Tyr Cys Asp Tyr Leu Asp Phe Gly Ile Asn Leu Thr Pro Glu Ser Pro 
            180                 185                 190         


Glu Ser Asn Phe Thr Ala Lys Val Thr Ala Val Asn Ser Leu Gly Ser 
        195                 200                 205             


Ser Ser Ser Leu Pro Ser Thr Phe Thr Phe Leu Asp Ile Val Arg Pro 
    210                 215                 220                 


Leu Pro Pro Trp Asp Ile Arg Ile Lys Phe Gln Lys Ala Ser Val Ser 
225                 230                 235                 240 


Arg Cys Thr Leu Tyr Trp Arg Asp Glu Gly Leu Val Leu Leu Asn Arg 
                245                 250                 255     


Leu Arg Tyr Arg Pro Ser Asn Ser Arg Leu Trp Asn Met Val Asn Val 
            260                 265                 270         


Thr Lys Ala Lys Gly Arg His Asp Leu Leu Asp Leu Lys Pro Phe Thr 
        275                 280                 285             


Glu Tyr Glu Phe Gln Ile Ser Ser Lys Leu His Leu Tyr Lys Gly Ser 
    290                 295                 300                 


Trp Ser Asp Trp Ser Glu Ser Leu Arg Ala Gln Thr Pro Glu Glu Glu 
305                 310                 315                 320 


Pro Thr Gly Met Leu Asp Val Trp Tyr Met Lys Arg His Ile Asp Tyr 
                325                 330                 335     


Ser Arg Gln Gln Ile Ser Leu Phe Trp Lys Asn Leu Ser Val Ser Glu 
            340                 345                 350         


Ala Arg Gly Lys Ile Leu His Tyr Gln Val Thr Leu Gln Glu Leu Thr 
        355                 360                 365             


Gly Gly Lys Ala Met Thr Gln Asn Ile Thr Gly His Thr Ser Trp Thr 
    370                 375                 380                 


Thr Val Ile Pro Arg Thr Gly Asn Trp Ala Val Ala Val Ser Ala Ala 
385                 390                 395                 400 


Asn Ser Lys Gly Ser Ser Leu Pro Thr Arg Ile Asn Ile Met Asn Leu 
                405                 410                 415     


Cys Glu Ala Gly Leu Leu Ala Pro Arg Gln Val Ser Ala Asn Ser Glu 
            420                 425                 430         


Gly Met Asp Asn Ile Leu Val Thr Trp Gln Pro Pro Arg Lys Asp Pro 
        435                 440                 445             


Ser Ala Val Gln Glu Tyr Val Val Glu Trp Arg Glu Leu His Pro Gly 
    450                 455                 460                 


Gly Asp Thr Gln Val Pro Leu Asn Trp Leu Arg Ser Arg Pro Tyr Asn 
465                 470                 475                 480 


Val Ser Ala Leu Ile Ser Glu Ile Pro Tyr Arg Val Ser Gln Asn Ser 
                485                 490                 495     


His Pro Ile Asn Ser Leu Gln Pro Arg Val Thr Tyr Val Leu Trp Met 
            500                 505                 510         


Thr Ala Leu Thr Ala Ala Gly Glu Ser Ser His Gly Asn Glu Arg Glu 
        515                 520                 525             


Phe Cys Leu Gln Gly Lys Ala Asn Trp Met Ala Phe Val Ala Pro Ser 
    530                 535                 540                 


Ile Cys Ile Ala Ile Ile Met Val Gly Ile Phe Ser Thr His Tyr Phe 
545                 550                 555                 560 


Gln Gln Lys Val Phe Val Leu Leu Ala Ala Leu Arg Pro Gln Trp Cys 
                565                 570                 575     


Ser Arg Glu Ile Pro Asp Pro Ala Asn Ser Thr Cys Ala Lys Lys Tyr 
            580                 585                 590         


Pro Ile Ala Glu Glu Lys Thr Gln Leu Pro Leu Asp Arg Leu Leu Ile 
        595                 600                 605             


Asp Trp Pro Thr Pro Glu Asp Pro Glu Pro Leu Val Ile Ser Glu Val 
    610                 615                 620                 


Leu His Gln Val Thr Pro Val Phe Arg His Pro Pro Cys Ser Asn Trp 
625                 630                 635                 640 


Pro Gln Arg Glu Lys Gly Ile Gln Gly His Gln Ala Ser Glu Lys Asp 
                645                 650                 655     


Met Met His Ser Ala Ser Ser Pro Pro Pro Pro Arg Ala Leu Gln Ala 
            660                 665                 670         


Glu Ser Arg Gln Leu Val Asp Leu Tyr Lys Val Leu Glu Ser Arg Gly 
        675                 680                 685             


Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu Pro 
    690                 695                 700                 


Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp 
705                 710                 715                 720 


Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu 
                725                 730                 735     


Glu Pro Gln His Ile Ser Leu Ser Val Phe Pro Ser Ser Ser Leu His 
            740                 745                 750         


Pro Leu Thr Phe Ser Cys Gly Asp Lys Leu Thr Leu Asp Gln Leu Lys 
        755                 760                 765             


Met Arg Cys Asp Ser Leu Met Leu 
    770                 775     


<210>  6876
<211>  230
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6876

Xaa Gln Lys Gly Glu Gln Gly Thr Val Ala Cys Thr Trp Glu Arg Gly 
1               5                   10                  15      


Arg Asp Thr His Leu Tyr Thr Glu Tyr Thr Leu Gln Leu Ser Gly Pro 
            20                  25                  30          


Lys Asn Leu Thr Trp Gln Lys Gln Cys Lys Asp Ile Tyr Cys Asp Tyr 
        35                  40                  45              


Leu Asp Phe Gly Ile Asn Leu Thr Pro Glu Ser Pro Glu Ser Asn Phe 
    50                  55                  60                  


Thr Ala Lys Val Thr Ala Val Asn Ser Leu Gly Ser Ser Ser Ser Leu 
65                  70                  75                  80  


Pro Ser Thr Phe Thr Phe Leu Asp Ile Val Arg Pro Leu Pro Pro Trp 
                85                  90                  95      


Asp Ile Arg Ile Lys Phe Gln Lys Ala Ser Val Ser Arg Cys Thr Leu 
            100                 105                 110         


Tyr Trp Arg Asp Glu Gly Leu Val Leu Leu Asn Arg Leu Arg Tyr Arg 
        115                 120                 125             


Pro Ser Asn Ser Arg Leu Trp Asn Met Val Asn Val Thr Lys Ala Lys 
    130                 135                 140                 


Gly Arg His Asp Leu Leu Asp Leu Lys Pro Phe Thr Glu Tyr Glu Phe 
145                 150                 155                 160 


Gln Ile Ser Ser Lys Leu His Leu Tyr Lys Gly Ser Trp Ser Asp Trp 
                165                 170                 175     


Ser Glu Ser Leu Arg Ala Gln Thr Pro Glu Glu Glu Pro Thr Gly Met 
            180                 185                 190         


Leu Asp Val Trp Tyr Met Lys Arg His Ile Asp Tyr Ser Arg Gln Gln 
        195                 200                 205             


Ile Ser Leu Phe Trp Lys Val Ser Phe Lys Arg Gln Leu Lys Thr Gln 
    210                 215                 220                 


Gly Asn Lys Thr Glu Gly 
225                 230 


<210>  6877
<211>  144
<212>  PRT
<213>  Homo Sapiens

<400>  6877

Met Ala Leu Leu Leu Thr Thr Val Ile Ala Leu Thr Cys Leu Gly Gly 
1               5                   10                  15      


Phe Ala Ser Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Arg Glu Leu 
            20                  25                  30          


Ile Glu Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys 
        35                  40                  45              


Asn Gly Ser Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys 
    50                  55                  60                  


Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu 
65                  70                  75                  80  


Lys Thr Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala 
                85                  90                  95      


Gly Gln Phe Ser Ser Leu His Val Arg Asp Thr Lys Ile Glu Val Ala 
            100                 105                 110         


Gln Phe Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe Arg Glu 
        115                 120                 125             


Gly Gln Phe Asn Asn Phe Glu Ser Ile Ile Ile Cys Arg Asp Arg Thr 
    130                 135                 140                 


<210>  6878
<211>  146
<212>  PRT
<213>  Homo Sapiens

<400>  6878

Met His Pro Leu Leu Asn Pro Leu Leu Leu Ala Leu Gly Leu Met Ala 
1               5                   10                  15      


Leu Leu Leu Thr Thr Val Ile Ala Leu Thr Cys Leu Gly Gly Phe Ala 
            20                  25                  30          


Ser Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Arg Glu Leu Ile Glu 
        35                  40                  45              


Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly 
    50                  55                  60                  


Ser Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala 
65                  70                  75                  80  


Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr 
                85                  90                  95      


Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln 
            100                 105                 110         


Phe Ser Ser Leu His Val Arg Asp Thr Lys Ile Glu Val Ala Gln Phe 
        115                 120                 125             


Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe Arg Glu Gly Gln 
    130                 135                 140                 


Phe Asn 
145     


<210>  6879
<211>  279
<212>  PRT
<213>  Homo Sapiens

<400>  6879

Met Glu Trp Pro Ala Arg Leu Cys Gly Leu Trp Ala Leu Leu Leu Cys 
1               5                   10                  15      


Ala Gly Gly Gly Gly Gly Gly Gly Gly Ala Ala Pro Thr Glu Thr Gln 
            20                  25                  30          


Pro Pro Val Thr Asn Leu Ser Val Ser Val Glu Asn Leu Cys Thr Val 
        35                  40                  45              


Ile Trp Thr Trp Asn Pro Pro Glu Gly Ala Ser Ser Asn Cys Ser Leu 
    50                  55                  60                  


Trp Tyr Phe Ser His Phe Gly Asp Lys Gln Asp Lys Lys Ile Ala Pro 
65                  70                  75                  80  


Glu Thr Arg Arg Ser Ile Glu Val Pro Leu Asn Glu Arg Ile Cys Leu 
                85                  90                  95      


Gln Val Gly Ser Gln Cys Ser Thr Asn Glu Ser Glu Lys Pro Ser Ile 
            100                 105                 110         


Leu Val Glu Lys Cys Ile Ser Pro Pro Glu Gly Asp Pro Glu Ser Ala 
        115                 120                 125             


Val Thr Glu Leu Gln Cys Ile Trp His Asn Leu Ser Tyr Met Lys Cys 
    130                 135                 140                 


Ser Trp Leu Pro Gly Arg Asn Thr Ser Pro Asp Thr Asn Tyr Thr Leu 
145                 150                 155                 160 


Tyr Tyr Trp His Arg Ser Leu Glu Lys Ile His Gln Cys Glu Asn Ile 
                165                 170                 175     


Phe Arg Glu Gly Gln Tyr Phe Gly Cys Ser Phe Asp Leu Thr Lys Val 
            180                 185                 190         


Lys Asp Ser Ser Phe Glu Gln His Ser Val Gln Ile Met Val Lys Asp 
        195                 200                 205             


Asn Ala Gly Lys Ile Lys Pro Ser Phe Asn Ile Val Pro Leu Thr Ser 
    210                 215                 220                 


Arg Val Lys Pro Asp Pro Pro His Ile Lys Asn Leu Ser Phe His Asn 
225                 230                 235                 240 


Asp Asp Leu Tyr Val Gln Trp Glu Asn Pro Gln Asn Phe Ile Ser Arg 
                245                 250                 255     


Cys Leu Phe Tyr Glu Val Glu Val Asn Asn Ser Gln Thr Glu Thr His 
            260                 265                 270         


Asn Val Phe Tyr Val Arg Phe 
        275                 


<210>  6880
<211>  427
<212>  PRT
<213>  Homo Sapiens

<400>  6880

Met Glu Trp Pro Ala Arg Leu Cys Gly Leu Trp Ala Leu Leu Leu Cys 
1               5                   10                  15      


Ala Gly Gly Gly Gly Gly Gly Gly Gly Ala Ala Pro Thr Glu Thr Gln 
            20                  25                  30          


Pro Pro Val Thr Asn Leu Ser Val Ser Val Glu Asn Leu Cys Thr Val 
        35                  40                  45              


Ile Trp Thr Trp Asn Pro Pro Glu Gly Ala Ser Ser Asn Cys Ser Leu 
    50                  55                  60                  


Trp Tyr Phe Ser His Phe Gly Asp Lys Gln Asp Lys Lys Ile Ala Pro 
65                  70                  75                  80  


Glu Thr Arg Arg Ser Ile Glu Val Pro Leu Asn Glu Arg Ile Cys Leu 
                85                  90                  95      


Gln Val Gly Ser Gln Cys Ser Thr Asn Glu Ser Glu Lys Pro Ser Ile 
            100                 105                 110         


Leu Val Glu Lys Cys Ile Ser Pro Pro Glu Gly Asp Pro Glu Ser Ala 
        115                 120                 125             


Val Thr Glu Leu Gln Cys Ile Trp His Asn Leu Ser Tyr Met Lys Cys 
    130                 135                 140                 


Ser Trp Leu Pro Gly Arg Asn Thr Ser Pro Asp Thr Asn Tyr Thr Leu 
145                 150                 155                 160 


Tyr Tyr Trp His Arg Ser Leu Glu Lys Ile His Gln Cys Glu Asn Ile 
                165                 170                 175     


Phe Arg Glu Gly Gln Tyr Phe Gly Cys Ser Phe Asp Leu Thr Lys Val 
            180                 185                 190         


Lys Asp Ser Ser Phe Glu Gln His Ser Val Gln Ile Met Val Lys Asp 
        195                 200                 205             


Asn Ala Gly Lys Ile Lys Pro Ser Phe Asn Ile Val Pro Leu Thr Ser 
    210                 215                 220                 


Arg Val Lys Pro Asp Pro Pro His Ile Lys Asn Leu Ser Phe His Asn 
225                 230                 235                 240 


Asp Asp Leu Tyr Val Gln Trp Glu Asn Pro Gln Asn Phe Ile Ser Arg 
                245                 250                 255     


Cys Leu Phe Tyr Glu Val Glu Val Asn Asn Ser Gln Thr Glu Thr His 
            260                 265                 270         


Asn Val Phe Tyr Val Gln Glu Ala Lys Cys Glu Asn Pro Glu Phe Glu 
        275                 280                 285             


Arg Asn Val Glu Asn Thr Ser Cys Phe Met Val Pro Gly Val Leu Pro 
    290                 295                 300                 


Asp Thr Leu Asn Thr Val Arg Ile Arg Val Lys Thr Asn Lys Leu Cys 
305                 310                 315                 320 


Tyr Glu Asp Asp Lys Leu Trp Ser Asn Trp Ser Gln Glu Met Ser Ile 
                325                 330                 335     


Gly Lys Lys Arg Asn Ser Thr Leu Tyr Ile Thr Met Leu Leu Ile Val 
            340                 345                 350         


Pro Val Ile Val Ala Gly Ala Ile Ile Val Leu Leu Leu Tyr Leu Lys 
        355                 360                 365             


Arg Leu Lys Ile Ile Ile Phe Pro Pro Ile Pro Asp Pro Gly Lys Ile 
    370                 375                 380                 


Phe Lys Glu Met Phe Gly Asp Gln Asn Asp Asp Thr Leu His Trp Lys 
385                 390                 395                 400 


Lys Tyr Asp Ile Tyr Glu Lys Gln Thr Lys Glu Glu Thr Asp Ser Val 
                405                 410                 415     


Val Leu Ile Glu Asn Leu Lys Lys Ala Ser Gln 
            420                 425         


<210>  6881
<211>  308
<212>  PRT
<213>  Homo Sapiens

<400>  6881

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Asp Ala Arg 
            20                  25                  30          


Asp Arg Leu Ala Val Leu Ala Gly Arg Ser Arg Ile Ser Glu Ser Phe 
        35                  40                  45              


Asn His Glu Val Gln Thr His Glu Ala Cys Val Arg Leu Arg Thr Met 
    50                  55                  60                  


Glu Asn Cys Pro Gln Cys His His His Arg Thr Ser Arg Gln Gln Ala 
65                  70                  75                  80  


Gly Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp 
                85                  90                  95      


Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser 
            100                 105                 110         


Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu 
        115                 120                 125             


Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
    130                 135                 140                 


Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr 
145                 150                 155                 160 


Val Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser 
                165                 170                 175     


Gly Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala 
            180                 185                 190         


Thr Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser 
        195                 200                 205             


Pro Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly 
    210                 215                 220                 


Thr Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala 
225                 230                 235                 240 


Ser His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr 
                245                 250                 255     


Val Ala Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val 
            260                 265                 270         


Ser Leu Leu Ala Cys Tyr Leu Lys Ser Ser Leu Asp Ala Phe Ile Lys 
        275                 280                 285             


Ile Arg Gly Gly Phe Ser Thr Trp Leu Leu Gly Leu Pro His Ser Thr 
    290                 295                 300                 


Val Gly Ser Gly 
305             


<210>  6882
<211>  346
<212>  PRT
<213>  Homo Sapiens

<400>  6882

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Asp Ala Arg 
            20                  25                  30          


Asp Arg Leu Ala Val Leu Ala Gly Arg Ser Arg Ile Ser Glu Ser Phe 
        35                  40                  45              


Asn His Glu Val Gln Thr His Glu Ala Cys Val Arg Leu Arg Thr Met 
    50                  55                  60                  


Glu Asn Cys Pro Gln Cys His His His Arg Thr Ser Arg Gln Gln Ala 
65                  70                  75                  80  


Gly Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp 
                85                  90                  95      


Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser 
            100                 105                 110         


Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu 
        115                 120                 125             


Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
    130                 135                 140                 


Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr 
145                 150                 155                 160 


Val Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser 
                165                 170                 175     


Gly Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala 
            180                 185                 190         


Thr Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser 
        195                 200                 205             


Pro Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly 
    210                 215                 220                 


Thr Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala 
225                 230                 235                 240 


Ser His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr 
                245                 250                 255     


Val Ala Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val 
            260                 265                 270         


Ser Leu Leu Ala Cys Tyr Leu Lys Ser Ser Ser His Ser Arg Glu Leu 
        275                 280                 285             


Thr Leu Leu Thr Leu Lys Trp Pro Lys Glu Leu Leu Leu Leu Arg Arg 
    290                 295                 300                 


Asp Ile Ser Pro Ala Leu Val Glu Gly Ala Gly Gln Met Pro Arg Ala 
305                 310                 315                 320 


Ser Ala Pro Arg Gln Leu Gln Thr Gly Gln Pro Arg Met Thr Ser Val 
                325                 330                 335     


Leu Pro Arg Leu Cys Leu Ser Phe Gly Ser 
            340                 345     


<210>  6883
<211>  305
<212>  PRT
<213>  Homo Sapiens

<400>  6883

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Asp Ala Arg 
            20                  25                  30          


Asp Arg Leu Ala Val Leu Ala Gly Arg Ser Arg Ile Ser Glu Ser Phe 
        35                  40                  45              


Asn His Glu Val Gln Thr His Glu Ala Cys Val Arg Leu Arg Thr Met 
    50                  55                  60                  


Glu Asn Cys Pro Gln Cys His His His Arg Thr Ser Arg Gln Gln Ala 
65                  70                  75                  80  


Gly Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp 
                85                  90                  95      


Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser 
            100                 105                 110         


Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu 
        115                 120                 125             


Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
    130                 135                 140                 


Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr 
145                 150                 155                 160 


Val Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser 
                165                 170                 175     


Gly Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala 
            180                 185                 190         


Thr Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser 
        195                 200                 205             


Pro Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly 
    210                 215                 220                 


Thr Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala 
225                 230                 235                 240 


Ser His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr 
                245                 250                 255     


Gly Arg Lys Gln His Leu Leu Pro Asp Phe Gln Ala Ser Phe Gln Arg 
            260                 265                 270         


Asp Cys Ile Asn Lys His Ile Glu Asp Lys Glu Cys Trp Thr Val Ala 
        275                 280                 285             


Ser Phe Leu Leu Phe Cys Thr Met Phe Val Ser Thr Cys Trp Tyr Thr 
    290                 295                 300                 


Leu 
305 


<210>  6884
<211>  331
<212>  PRT
<213>  Homo Sapiens

<400>  6884

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Asp Ala Arg 
            20                  25                  30          


Asp Arg Leu Ala Val Leu Ala Gly Arg Ser Arg Ile Ser Glu Ser Phe 
        35                  40                  45              


Asn His Glu Val Gln Thr His Glu Ala Cys Val Arg Leu Arg Thr Met 
    50                  55                  60                  


Glu Asn Cys Pro Gln Cys His His His Arg Thr Ser Arg Gln Gln Ala 
65                  70                  75                  80  


Gly Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp 
                85                  90                  95      


Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser 
            100                 105                 110         


Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu 
        115                 120                 125             


Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
    130                 135                 140                 


Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr 
145                 150                 155                 160 


Val Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser 
                165                 170                 175     


Gly Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala 
            180                 185                 190         


Thr Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser 
        195                 200                 205             


Pro Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly 
    210                 215                 220                 


Thr Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala 
225                 230                 235                 240 


Ser His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr 
                245                 250                 255     


Val Ala Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val 
            260                 265                 270         


Ser Leu Leu Ala Cys Tyr Leu Lys Ser Arg Trp Leu Ala Lys Arg Ser 
        275                 280                 285             


Leu Pro Gly Asp Ala Glu Ala Pro Asn Met Ser Arg Gly Gly Arg Asn 
    290                 295                 300                 


Ala Trp Glu Gln Leu Ser Arg Ala Pro Ala Thr Ser Leu Leu Arg Thr 
305                 310                 315                 320 


Pro Val Glu Ser Ala Leu Ser Ala Ser Arg Pro 
                325                 330     


<210>  6885
<211>  154
<212>  PRT
<213>  Homo Sapiens

<400>  6885

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Glu Pro Ala 
            20                  25                  30          


Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala Ile 
        35                  40                  45              


Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr Gly Thr 
    50                  55                  60                  


Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser Gln Thr 
65                  70                  75                  80  


Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro Pro 
                85                  90                  95      


Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile Ser Thr 
            100                 105                 110         


Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu Ala Cys 
        115                 120                 125             


Tyr Leu Lys Ser Arg Ala Ser Val Cys Ser Cys His Pro Arg Ser Ala 
    130                 135                 140                 


Gly His Thr Cys Ser Val Gly Ser Val Cys 
145                 150                 


<210>  6886
<211>  169
<212>  PRT
<213>  Homo Sapiens

<400>  6886

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Glu Pro Ala 
            20                  25                  30          


Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala Ile 
        35                  40                  45              


Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr Gly Thr 
    50                  55                  60                  


Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser Gln Thr 
65                  70                  75                  80  


Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro Pro 
                85                  90                  95      


Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile Ser Thr 
            100                 105                 110         


Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu Ala Cys 
        115                 120                 125             


Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu Met Glu 
    130                 135                 140                 


Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg Asp Glu 
145                 150                 155                 160 


Asp Leu Glu Asn Cys Ser His His Leu 
                165                 


<210>  6887
<211>  172
<212>  PRT
<213>  Homo Sapiens

<400>  6887

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Lys Pro 
                85                  90                  95      


Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala 
            100                 105                 110         


Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr Gly 
        115                 120                 125             


Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser Gln 
    130                 135                 140                 


Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro 
145                 150                 155                 160 


Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr 
                165                 170         


<210>  6888
<211>  219
<212>  PRT
<213>  Homo Sapiens

<400>  6888

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Lys Pro 
                85                  90                  95      


Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala 
            100                 105                 110         


Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr Gly 
        115                 120                 125             


Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser Gln 
    130                 135                 140                 


Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro 
145                 150                 155                 160 


Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile Ser 
                165                 170                 175     


Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu Ala 
            180                 185                 190         


Cys Tyr Leu Lys Ser Arg Ala Ser Val Cys Ser Cys His Pro Arg Ser 
        195                 200                 205             


Ala Gly His Thr Cys Ser Val Gly Ser Val Cys 
    210                 215                 


<210>  6889
<211>  234
<212>  PRT
<213>  Homo Sapiens

<400>  6889

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Lys Pro 
                85                  90                  95      


Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala 
            100                 105                 110         


Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr Gly 
        115                 120                 125             


Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser Gln 
    130                 135                 140                 


Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro 
145                 150                 155                 160 


Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile Ser 
                165                 170                 175     


Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu Ala 
            180                 185                 190         


Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu Met 
        195                 200                 205             


Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg Asp 
    210                 215                 220                 


Glu Asp Leu Glu Asn Cys Ser His His Leu 
225                 230                 


<210>  6890
<211>  252
<212>  PRT
<213>  Homo Sapiens

<400>  6890

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
                85                  90                  95      


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
            100                 105                 110         


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
        115                 120                 125             


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
    130                 135                 140                 


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
145                 150                 155                 160 


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
                165                 170                 175     


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
            180                 185                 190         


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
        195                 200                 205             


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
    210                 215                 220                 


Ala Cys Tyr Leu Lys Ser Arg Ala Ser Val Cys Ser Cys His Pro Arg 
225                 230                 235                 240 


Ser Ala Gly His Thr Cys Ser Val Gly Ser Val Cys 
                245                 250         


<210>  6891
<211>  267
<212>  PRT
<213>  Homo Sapiens

<400>  6891

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
                85                  90                  95      


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
            100                 105                 110         


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
        115                 120                 125             


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
    130                 135                 140                 


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
145                 150                 155                 160 


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
                165                 170                 175     


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
            180                 185                 190         


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
        195                 200                 205             


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
    210                 215                 220                 


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
225                 230                 235                 240 


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
                245                 250                 255     


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu 
            260                 265         


<210>  6892
<211>  353
<212>  PRT
<213>  Homo Sapiens

<400>  6892

Met Arg Leu Ala Gly Arg Gln Val Pro Glu Gln Arg Ser Pro Pro Pro 
1               5                   10                  15      


Pro Gly Leu Gly Ser Ala Arg Pro Gly Ser Pro Ala Val Ser Cys Gly 
            20                  25                  30          


Ala Ala Ala Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly 
        35                  40                  45              


Leu Pro Ala Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg 
    50                  55                  60                  


Asp Ala Arg Asp Arg Leu Ala Val Leu Ala Gly Arg Ser Arg Ile Ser 
65                  70                  75                  80  


Glu Ser Phe Asn His Glu Val Gln Thr His Glu Ala Cys Val Arg Leu 
                85                  90                  95      


Arg Thr Met Glu Asn Cys Pro Gln Cys His His His Arg Thr Ser Arg 
            100                 105                 110         


Gln Gln Ala Gly Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala 
        115                 120                 125             


Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile 
    130                 135                 140                 


Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu 
145                 150                 155                 160 


Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser 
                165                 170                 175     


Leu Lys Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro 
            180                 185                 190         


Pro Ser Thr Val Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu 
        195                 200                 205             


Ser Pro Ser Gly Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn 
    210                 215                 220                 


Thr Ala Ala Thr Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro 
225                 230                 235                 240 


Ser Lys Ser Pro Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser 
                245                 250                 255     


Ser His Gly Thr Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr 
            260                 265                 270         


Ala Ser Ala Ser His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser 
        275                 280                 285             


Asp Thr Thr Val Ala Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu 
    290                 295                 300                 


Ser Ala Val Ser Leu Leu Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro 
305                 310                 315                 320 


Pro Leu Ala Ser Val Glu Met Glu Ala Met Glu Ala Leu Pro Val Thr 
                325                 330                 335     


Trp Gly Thr Ser Ser Arg Asp Glu Asp Leu Glu Asn Cys Ser His His 
            340                 345                 350         


Leu 
    


<210>  6893
<211>  172
<212>  PRT
<213>  Homo Sapiens

<400>  6893

Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr 
1               5                   10                  15      


Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly 
            20                  25                  30          


Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala 
        35                  40                  45              


His Trp Thr Thr Pro Ser Leu Lys Cys Ile Lys Pro Ala Ala Ser Ser 
    50                  55                  60                  


Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala Ile Val Pro Gly 
65                  70                  75                  80  


Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr Gly Thr Thr Glu Ile 
                85                  90                  95      


Ser Ser His Glu Ser Ser His Gly Thr Pro Ser Gln Thr Thr Ala Lys 
            100                 105                 110         


Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro Pro Gly Val Tyr 
        115                 120                 125             


Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile Ser Thr Ser Thr Val 
    130                 135                 140                 


Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu Ala Cys Tyr Leu Lys 
145                 150                 155                 160 


Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu Met 
                165                 170         


<210>  6894
<211>  148
<212>  PRT
<213>  Homo Sapiens

<400>  6894

Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr 
1               5                   10                  15      


Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly 
            20                  25                  30          


Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala 
        35                  40                  45              


His Trp Thr Thr Pro Ser Leu Lys Cys Ile Asn Pro Ala Leu Val His 
    50                  55                  60                  


Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr Ala Gly Val Thr Pro 
65                  70                  75                  80  


Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu Pro Ala Ala Ser Ser 
                85                  90                  95      


Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala Ile Val Pro Gly 
            100                 105                 110         


Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr Gly Thr Thr Glu Ile 
        115                 120                 125             


Ser Ser His Glu Ser Ser His Gly Thr Pro Ser Gln Thr Thr Ala Lys 
    130                 135                 140                 


Asn Trp Glu Leu 
145             


<210>  6895
<211>  231
<212>  PRT
<213>  Homo Sapiens

<400>  6895

Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr 
1               5                   10                  15      


Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly 
            20                  25                  30          


Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala 
        35                  40                  45              


His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Val 
    50                  55                  60                  


His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr Ala Gly Val Thr 
65                  70                  75                  80  


Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu Pro Ala Ala Ser 
                85                  90                  95      


Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala Ile Val Pro 
            100                 105                 110         


Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr Gly Thr Thr Glu 
        115                 120                 125             


Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser Gln Thr Thr Ala 
    130                 135                 140                 


Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro Pro Gly Val 
145                 150                 155                 160 


Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile Ser Thr Ser Thr 
                165                 170                 175     


Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu Ala Cys Tyr Leu 
            180                 185                 190         


Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu Met Glu Ala Met 
        195                 200                 205             


Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg Asp Glu Asp Leu 
    210                 215                 220                 


Glu Asn Cys Ser His His Leu 
225                 230     


<210>  6896
<211>  209
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6896

Xaa Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp 
1               5                   10                  15      


Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser 
            20                  25                  30          


Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu 
        35                  40                  45              


Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
    50                  55                  60                  


Ile Arg Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro 
65                  70                  75                  80  


Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His 
                85                  90                  95      


Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Gly Arg 
            100                 105                 110         


Lys Gln His Leu Leu Pro Asp Phe Gln Ala Ser Phe Gln Arg Asp Cys 
        115                 120                 125             


Ile Asn Lys His Ile Glu Asp Lys Glu Cys Trp Thr Val Ala Ser Phe 
    130                 135                 140                 


Leu Leu Phe Leu Ala Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu 
145                 150                 155                 160 


Ser Ala Val Ser Leu Leu Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro 
                165                 170                 175     


Pro Leu Ala Ser Val Glu Met Glu Ala Met Glu Ala Leu Pro Val Thr 
            180                 185                 190         


Trp Gly Thr Ser Ser Arg Asp Glu Asp Leu Glu Asn Cys Ser His His 
        195                 200                 205             


Leu 
    


<210>  6897
<211>  155
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6897

Xaa Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr Ala 
1               5                   10                  15      


Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu Pro 
            20                  25                  30          


Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala 
        35                  40                  45              


Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr Gly 
    50                  55                  60                  


Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser Gln 
65                  70                  75                  80  


Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro 
                85                  90                  95      


Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile Ser 
            100                 105                 110         


Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu Ala 
        115                 120                 125             


Cys Tyr Leu Lys Ser Arg Ala Ser Val Cys Ser Cys His Pro Arg Ser 
    130                 135                 140                 


Ala Gly His Thr Cys Ser Val Gly Ser Val Cys 
145                 150                 155 


<210>  6898
<211>  198
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6898

Xaa Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr 
1               5                   10                  15      


Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser 
            20                  25                  30          


Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro 
        35                  40                  45              


Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His 
    50                  55                  60                  


Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala 
65                  70                  75                  80  


Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu 
                85                  90                  95      


Leu Ala Cys Tyr Leu Lys Ser Ser Ser Gln Arg Lys Val Thr Tyr Leu 
            100                 105                 110         


Arg Leu Ser Val Asn Tyr Lys Ala Pro Pro Gly Val Gly Asp Val Tyr 
        115                 120                 125             


Arg Glu Asp Thr Ser Val Trp Ala Pro Pro Asn Asp Pro Val Ser Ser 
    130                 135                 140                 


Cys Ala Ala Arg Thr Asp Arg Glu Pro Glu Lys Val Glu Glu Met Leu 
145                 150                 155                 160 


Ser Pro Val Asn Pro Leu His Arg Arg Ile Gln Glu Glu Glu Asn Ser 
                165                 170                 175     


Ser Gln Arg His Phe Thr Tyr Ile Cys Ile Tyr Thr Ser Leu Ser Val 
            180                 185                 190         


Ile Ser Thr His Tyr Ile 
        195             


<210>  6899
<211>  155
<212>  PRT
<213>  Homo Sapiens

<400>  6899

Met Thr Pro Gly Lys Thr Ser Leu Val Ser Leu Leu Leu Leu Leu Ser 
1               5                   10                  15      


Leu Glu Ala Ile Val Lys Ala Gly Ile Thr Ile Pro Arg Asn Pro Gly 
            20                  25                  30          


Cys Pro Asn Ser Glu Asp Lys Asn Phe Pro Arg Thr Val Met Val Asn 
        35                  40                  45              


Leu Asn Ile His Asn Arg Asn Thr Asn Thr Asn Pro Lys Arg Ser Ser 
    50                  55                  60                  


Asp Tyr Tyr Asn Arg Ser Thr Ser Pro Trp Asn Leu His Arg Asn Glu 
65                  70                  75                  80  


Asp Pro Glu Arg Tyr Pro Ser Val Ile Trp Glu Ala Lys Cys Arg His 
                85                  90                  95      


Leu Gly Cys Ile Asn Ala Asp Gly Asn Val Asp Tyr His Met Asn Ser 
            100                 105                 110         


Val Pro Ile Gln Gln Glu Ile Leu Val Leu Arg Arg Glu Pro Pro His 
        115                 120                 125             


Cys Pro Asn Ser Phe Arg Leu Glu Lys Ile Leu Val Ser Val Gly Cys 
    130                 135                 140                 


Thr Cys Val Thr Pro Ile Val His His Val Ala 
145                 150                 155 


<210>  6900
<211>  180
<212>  PRT
<213>  Homo Sapiens

<400>  6900

Met Asp Trp Pro His Asn Leu Leu Phe Leu Leu Thr Ile Ser Ile Phe 
1               5                   10                  15      


Leu Gly Leu Gly Gln Pro Arg Ser Pro Lys Ser Lys Arg Lys Gly Gln 
            20                  25                  30          


Gly Arg Pro Gly Pro Leu Ala Pro Gly Pro His Gln Val Pro Leu Asp 
        35                  40                  45              


Leu Val Ser Arg Met Lys Pro Tyr Ala Arg Met Glu Glu Tyr Glu Arg 
    50                  55                  60                  


Asn Ile Glu Glu Met Val Ala Gln Leu Arg Asn Ser Ser Glu Leu Ala 
65                  70                  75                  80  


Gln Arg Lys Cys Glu Val Asn Leu Gln Leu Trp Met Ser Asn Lys Arg 
                85                  90                  95      


Ser Leu Ser Pro Trp Gly Tyr Ser Ile Asn His Asp Pro Ser Arg Ile 
            100                 105                 110         


Pro Val Asp Leu Pro Glu Ala Arg Cys Leu Cys Leu Gly Cys Val Asn 
        115                 120                 125             


Pro Phe Thr Met Gln Glu Asp Arg Ser Met Val Ser Val Pro Val Phe 
    130                 135                 140                 


Ser Gln Val Pro Val Arg Arg Arg Leu Cys Pro Pro Pro Pro Arg Thr 
145                 150                 155                 160 


Gly Pro Cys Arg Gln Arg Ala Val Met Glu Thr Ile Ala Val Gly Cys 
                165                 170                 175     


Thr Cys Ile Phe 
            180 


<210>  6901
<211>  197
<212>  PRT
<213>  Homo Sapiens

<400>  6901

Met Thr Leu Leu Pro Gly Leu Leu Phe Leu Thr Trp Leu His Thr Cys 
1               5                   10                  15      


Leu Ala His His Asp Pro Ser Leu Arg Gly His Pro His Ser His Gly 
            20                  25                  30          


Thr Pro His Cys Tyr Ser Ala Glu Glu Leu Pro Leu Gly Gln Ala Pro 
        35                  40                  45              


Pro His Leu Leu Ala Arg Gly Ala Lys Trp Gly Gln Ala Leu Pro Val 
    50                  55                  60                  


Ala Leu Val Ser Ser Leu Glu Ala Ala Ser His Arg Gly Arg His Glu 
65                  70                  75                  80  


Arg Pro Ser Ala Thr Thr Gln Cys Pro Val Leu Arg Pro Glu Glu Val 
                85                  90                  95      


Leu Glu Ala Asp Thr His Gln Arg Ser Ile Ser Pro Trp Arg Tyr Arg 
            100                 105                 110         


Val Asp Thr Asp Glu Asp Arg Tyr Pro Gln Lys Leu Ala Phe Ala Glu 
        115                 120                 125             


Cys Leu Cys Arg Gly Cys Ile Asp Ala Arg Thr Gly Arg Glu Thr Ala 
    130                 135                 140                 


Ala Leu Asn Ser Val Arg Leu Leu Gln Ser Leu Leu Val Leu Arg Arg 
145                 150                 155                 160 


Arg Pro Cys Ser Arg Asp Gly Ser Gly Leu Pro Thr Pro Gly Ala Phe 
                165                 170                 175     


Ala Phe His Thr Glu Phe Ile His Val Pro Val Gly Cys Thr Cys Val 
            180                 185                 190         


Leu Pro Arg Ser Val 
        195         


<210>  6902
<211>  35
<212>  PRT
<213>  Homo Sapiens

<400>  6902

Met Leu Gly Ala Leu Val Trp Met Leu Val Ala Gly Phe Leu Leu Ala 
1               5                   10                  15      


Leu Pro Pro Ser Trp Ala Ala Gly Ala Pro Arg Ala Gly Arg Arg Pro 
            20                  25                  30          


Ala Arg Pro 
        35  


<210>  6903
<211>  202
<212>  PRT
<213>  Homo Sapiens

<400>  6903

Met Leu Val Ala Gly Phe Leu Leu Ala Leu Pro Pro Ser Trp Ala Ala 
1               5                   10                  15      


Gly Ala Pro Arg Ala Gly Arg Arg Pro Ala Arg Pro Arg Gly Cys Ala 
            20                  25                  30          


Asp Arg Pro Glu Glu Leu Leu Glu Gln Leu Tyr Gly Arg Leu Ala Ala 
        35                  40                  45              


Gly Val Leu Ser Ala Phe His His Thr Leu Gln Leu Gly Pro Arg Glu 
    50                  55                  60                  


Gln Ala Arg Asn Ala Ser Cys Pro Ala Gly Gly Arg Pro Ala Asp Arg 
65                  70                  75                  80  


Arg Phe Arg Pro Pro Thr Asn Leu Arg Ser Val Ser Pro Trp Ala Tyr 
                85                  90                  95      


Arg Ile Ser Tyr Asp Pro Ala Arg Tyr Pro Arg Tyr Leu Pro Glu Ala 
            100                 105                 110         


Tyr Cys Leu Cys Arg Gly Cys Leu Thr Gly Leu Phe Gly Glu Glu Asp 
        115                 120                 125             


Val Arg Phe Arg Ser Ala Pro Val Tyr Met Pro Thr Val Val Leu Arg 
    130                 135                 140                 


Arg Thr Pro Ala Cys Ala Gly Gly Arg Ser Val Tyr Thr Glu Ala Tyr 
145                 150                 155                 160 


Val Thr Ile Pro Val Gly Cys Thr Cys Val Pro Glu Pro Glu Lys Asp 
                165                 170                 175     


Ala Asp Ser Ile Asn Ser Ser Ile Asp Lys Gln Gly Ala Lys Leu Leu 
            180                 185                 190         


Leu Gly Pro Asn Asp Ala Pro Ala Gly Pro 
        195                 200         


<210>  6904
<211>  90
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6904

Xaa Arg Pro Arg Gly Cys Ala Asp Arg Pro Glu Glu Leu Leu Glu Gln 
1               5                   10                  15      


Leu Tyr Gly Arg Leu Ala Ala Gly Val Leu Ser Ala Phe His His Thr 
            20                  25                  30          


Leu Gln Leu Gly Pro Arg Glu Gln Ala Arg Asn Ala Ser Cys Pro Ala 
        35                  40                  45              


Gly Gly Arg Pro Ala Asp Arg Arg Phe Arg Pro Pro Thr Asn Leu Arg 
    50                  55                  60                  


Ser Val Ser Pro Trp Ala Tyr Ser Ser Val Ser Ile Thr Ser Asn His 
65                  70                  75                  80  


Pro Trp Arg Thr Arg Pro Leu Phe Leu Asp 
                85                  90  


<210>  6905
<211>  163
<212>  PRT
<213>  Homo Sapiens

<400>  6905

Met Thr Val Lys Thr Leu His Gly Pro Ala Met Val Lys Tyr Leu Leu 
1               5                   10                  15      


Leu Ser Ile Leu Gly Leu Ala Phe Leu Ser Glu Ala Ala Ala Arg Lys 
            20                  25                  30          


Ile Pro Lys Val Gly His Thr Phe Phe Gln Lys Pro Glu Ser Cys Pro 
        35                  40                  45              


Pro Val Pro Gly Gly Ser Met Lys Leu Asp Ile Gly Ile Ile Asn Glu 
    50                  55                  60                  


Asn Gln Arg Val Ser Met Ser Arg Asn Ile Glu Ser Arg Ser Thr Ser 
65                  70                  75                  80  


Pro Trp Asn Tyr Thr Val Thr Trp Asp Pro Asn Arg Tyr Pro Ser Glu 
                85                  90                  95      


Val Val Gln Ala Gln Cys Arg Asn Leu Gly Cys Ile Asn Ala Gln Gly 
            100                 105                 110         


Lys Glu Asp Ile Ser Met Asn Ser Val Pro Ile Gln Gln Glu Thr Leu 
        115                 120                 125             


Val Val Arg Arg Lys His Gln Gly Cys Ser Val Ser Phe Gln Leu Glu 
    130                 135                 140                 


Lys Val Leu Val Thr Val Gly Cys Thr Cys Val Thr Pro Val Ile His 
145                 150                 155                 160 


His Val Gln 
            


<210>  6906
<211>  866
<212>  PRT
<213>  Homo Sapiens

<400>  6906

Met Gly Ala Ala Arg Ser Pro Pro Ser Ala Val Pro Gly Pro Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Leu Leu Leu Gly Val Leu Ala Pro Gly Gly Ala Ser 
            20                  25                  30          


Leu Arg Leu Leu Asp His Arg Ala Leu Val Cys Ser Gln Pro Gly Leu 
        35                  40                  45              


Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile His 
    50                  55                  60                  


Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln Leu 
65                  70                  75                  80  


His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His Ile 
                85                  90                  95      


Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala 
            100                 105                 110         


Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Arg 
        115                 120                 125             


Phe Glu Phe Leu Ser Lys Leu Arg His His His Arg Arg Trp Arg Phe 
    130                 135                 140                 


Thr Phe Ser His Phe Val Val Asp Pro Asp Gln Glu Tyr Glu Val Thr 
145                 150                 155                 160 


Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Gln 
                165                 170                 175     


Ser Lys Asn Phe Leu Val Pro Asp Cys Glu His Ala Arg Met Lys Val 
            180                 185                 190         


Thr Thr Pro Cys Met Ser Ser Gly Ser Leu Trp Asp Pro Asn Ile Thr 
        195                 200                 205             


Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser Phe Thr Leu Trp 
    210                 215                 220                 


Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser Phe Pro His Met 
225                 230                 235                 240 


Glu Asn His Ser Cys Phe Glu His Met His His Ile Pro Ala Pro Arg 
                245                 250                 255     


Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu Thr Leu Arg Asn 
            260                 265                 270         


Leu Lys Gly Cys Cys Arg His Gln Val Gln Ile Gln Pro Phe Phe Ser 
        275                 280                 285             


Ser Cys Leu Asn Asp Cys Leu Arg His Ser Ala Thr Val Ser Cys Pro 
    290                 295                 300                 


Glu Met Pro Asp Thr Pro Glu Pro Ile Pro Asp Tyr Met Pro Leu Trp 
305                 310                 315                 320 


Val Tyr Trp Phe Ile Thr Gly Ile Ser Ile Leu Leu Val Gly Ser Val 
                325                 330                 335     


Ile Leu Leu Ile Val Cys Met Thr Trp Arg Leu Ala Gly Pro Gly Ser 
            340                 345                 350         


Glu Lys Tyr Ser Asp Asp Thr Lys Tyr Thr Asp Gly Leu Pro Ala Ala 
        355                 360                 365             


Asp Leu Ile Pro Pro Pro Leu Lys Pro Arg Lys Val Trp Ile Ile Tyr 
    370                 375                 380                 


Ser Ala Asp His Pro Leu Tyr Val Asp Val Val Leu Lys Phe Ala Gln 
385                 390                 395                 400 


Phe Leu Leu Thr Ala Cys Gly Thr Glu Val Ala Leu Asp Leu Leu Glu 
                405                 410                 415     


Glu Gln Ala Ile Ser Glu Ala Gly Val Met Thr Trp Val Gly Arg Gln 
            420                 425                 430         


Lys Gln Glu Met Val Glu Ser Asn Ser Lys Ile Ile Val Leu Cys Ser 
        435                 440                 445             


Arg Gly Thr Arg Ala Lys Trp Gln Ala Leu Leu Gly Arg Gly Ala Pro 
    450                 455                 460                 


Val Arg Leu Arg Cys Asp His Gly Lys Pro Val Gly Asp Leu Phe Thr 
465                 470                 475                 480 


Ala Ala Met Asn Met Ile Leu Pro Asp Phe Lys Arg Pro Ala Cys Phe 
                485                 490                 495     


Gly Thr Tyr Val Val Cys Tyr Phe Ser Glu Val Ser Cys Asp Gly Asp 
            500                 505                 510         


Val Pro Asp Leu Phe Gly Ala Ala Pro Arg Tyr Pro Leu Met Asp Arg 
        515                 520                 525             


Phe Glu Glu Val Tyr Phe Arg Ile Gln Asp Leu Glu Met Phe Gln Pro 
    530                 535                 540                 


Gly Arg Met His Arg Val Gly Glu Leu Ser Gly Asp Asn Tyr Leu Arg 
545                 550                 555                 560 


Ser Pro Gly Gly Arg Gln Leu Arg Ala Ala Leu Asp Arg Phe Arg Asp 
                565                 570                 575     


Trp Gln Val Arg Cys Pro Asp Trp Phe Glu Cys Glu Asn Leu Tyr Ser 
            580                 585                 590         


Ala Asp Asp Gln Asp Ala Pro Ser Leu Asp Glu Glu Val Phe Glu Glu 
        595                 600                 605             


Pro Leu Leu Pro Pro Gly Thr Gly Ile Val Lys Arg Ala Pro Leu Val 
    610                 615                 620                 


Arg Glu Pro Gly Ser Gln Ala Cys Leu Ala Ile Asp Pro Leu Val Gly 
625                 630                 635                 640 


Glu Glu Gly Gly Ala Ala Val Ala Lys Leu Glu Pro His Leu Gln Pro 
                645                 650                 655     


Arg Gly Gln Pro Ala Pro Gln Pro Leu His Thr Leu Val Leu Ala Ala 
            660                 665                 670         


Glu Glu Gly Ala Leu Val Ala Ala Val Glu Pro Gly Pro Leu Ala Asp 
        675                 680                 685             


Gly Ala Ala Val Arg Leu Ala Leu Ala Gly Glu Gly Glu Ala Cys Pro 
    690                 695                 700                 


Leu Leu Gly Ser Pro Gly Ala Gly Arg Asn Ser Val Leu Phe Leu Pro 
705                 710                 715                 720 


Val Asp Pro Glu Asp Ser Pro Leu Gly Ser Ser Thr Pro Met Ala Ser 
                725                 730                 735     


Pro Asp Leu Leu Pro Glu Asp Val Arg Glu His Leu Glu Gly Leu Met 
            740                 745                 750         


Leu Ser Leu Phe Glu Gln Ser Leu Ser Cys Gln Ala Gln Gly Gly Cys 
        755                 760                 765             


Ser Arg Pro Ala Met Val Leu Thr Asp Pro His Thr Pro Tyr Glu Glu 
    770                 775                 780                 


Glu Gln Arg Gln Ser Val Gln Ser Asp Gln Gly Tyr Ile Ser Arg Ser 
785                 790                 795                 800 


Ser Pro Gln Pro Pro Glu Gly Leu Thr Glu Met Glu Glu Glu Glu Glu 
                805                 810                 815     


Glu Glu Gln Asp Pro Gly Lys Pro Ala Leu Pro Leu Ser Pro Glu Asp 
            820                 825                 830         


Leu Glu Ser Leu Arg Ser Leu Gln Arg Gln Leu Leu Phe Arg Gln Leu 
        835                 840                 845             


Gln Lys Asn Ser Gly Trp Asp Thr Met Gly Ser Glu Ser Glu Gly Pro 
    850                 855                 860                 


Ser Ala 
865     


<210>  6907
<211>  832
<212>  PRT
<213>  Homo Sapiens

<400>  6907

Met Gly Ala Ala Arg Ser Pro Pro Ser Ala Val Pro Gly Pro Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Leu Leu Leu Gly Val Leu Ala Pro Gly Gly Ala Ser 
            20                  25                  30          


Leu Arg Leu Leu Asp His Arg Ala Leu Val Cys Ser Gln Pro Gly Leu 
        35                  40                  45              


Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile His 
    50                  55                  60                  


Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln Leu 
65                  70                  75                  80  


His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His Ile 
                85                  90                  95      


Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala 
            100                 105                 110         


Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Arg 
        115                 120                 125             


Phe Glu Phe Leu Ser Lys Leu Arg His His His Arg Arg Trp Arg Phe 
    130                 135                 140                 


Thr Phe Ser His Phe Val Val Asp Pro Asp Gln Glu Tyr Glu Val Thr 
145                 150                 155                 160 


Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Gln 
                165                 170                 175     


Ser Lys Asn Phe Leu Val Pro Asp Cys Glu His Ala Arg Met Lys Val 
            180                 185                 190         


Thr Thr Pro Cys Met Ser Ser Gly Ser Leu Trp Asp Pro Asn Ile Thr 
        195                 200                 205             


Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser Phe Thr Leu Trp 
    210                 215                 220                 


Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser Phe Pro His Met 
225                 230                 235                 240 


Glu Asn His Ser Cys Phe Glu His Met His His Ile Pro Ala Pro Arg 
                245                 250                 255     


Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu Thr Leu Arg Asn 
            260                 265                 270         


Leu Lys Gly Cys Cys Arg His Gln Val Gln Ile Gln Pro Phe Phe Ser 
        275                 280                 285             


Ser Cys Leu Asn Asp Cys Leu Arg His Ser Ala Thr Val Ser Cys Pro 
    290                 295                 300                 


Glu Met Pro Asp Thr Pro Glu Pro Ile Pro Gly Pro Gly Ser Glu Lys 
305                 310                 315                 320 


Tyr Ser Asp Asp Thr Lys Tyr Thr Asp Gly Leu Pro Ala Ala Asp Leu 
                325                 330                 335     


Ile Pro Pro Pro Leu Lys Pro Arg Lys Val Trp Ile Ile Tyr Ser Ala 
            340                 345                 350         


Asp His Pro Leu Tyr Val Asp Val Val Leu Lys Phe Ala Gln Phe Leu 
        355                 360                 365             


Leu Thr Ala Cys Gly Thr Glu Val Ala Leu Asp Leu Leu Glu Glu Gln 
    370                 375                 380                 


Ala Ile Ser Glu Ala Gly Val Met Thr Trp Val Gly Arg Gln Lys Gln 
385                 390                 395                 400 


Glu Met Val Glu Ser Asn Ser Lys Ile Ile Val Leu Cys Ser Arg Gly 
                405                 410                 415     


Thr Arg Ala Lys Trp Gln Ala Leu Leu Gly Arg Gly Ala Pro Val Arg 
            420                 425                 430         


Leu Arg Cys Asp His Gly Lys Pro Val Gly Asp Leu Phe Thr Ala Ala 
        435                 440                 445             


Met Asn Met Ile Leu Pro Asp Phe Lys Arg Pro Ala Cys Phe Gly Thr 
    450                 455                 460                 


Tyr Val Val Cys Tyr Phe Ser Glu Val Ser Cys Asp Gly Asp Val Pro 
465                 470                 475                 480 


Asp Leu Phe Gly Ala Ala Pro Arg Tyr Pro Leu Met Asp Arg Phe Glu 
                485                 490                 495     


Glu Val Tyr Phe Arg Ile Gln Asp Leu Glu Met Phe Gln Pro Gly Arg 
            500                 505                 510         


Met His Arg Val Gly Glu Leu Ser Gly Asp Asn Tyr Leu Arg Ser Pro 
        515                 520                 525             


Gly Gly Arg Gln Leu Arg Ala Ala Leu Asp Arg Phe Arg Asp Trp Gln 
    530                 535                 540                 


Val Arg Cys Pro Asp Trp Phe Glu Cys Glu Asn Leu Tyr Ser Ala Asp 
545                 550                 555                 560 


Asp Gln Asp Ala Pro Ser Leu Asp Glu Glu Val Phe Glu Glu Pro Leu 
                565                 570                 575     


Leu Pro Pro Gly Thr Gly Ile Val Lys Arg Ala Pro Leu Val Arg Glu 
            580                 585                 590         


Pro Gly Ser Gln Ala Cys Leu Ala Ile Asp Pro Leu Val Gly Glu Glu 
        595                 600                 605             


Gly Gly Ala Ala Val Ala Lys Leu Glu Pro His Leu Gln Pro Arg Gly 
    610                 615                 620                 


Gln Pro Ala Pro Gln Pro Leu His Thr Leu Val Leu Ala Ala Glu Glu 
625                 630                 635                 640 


Gly Ala Leu Val Ala Ala Val Glu Pro Gly Pro Leu Ala Asp Gly Ala 
                645                 650                 655     


Ala Val Arg Leu Ala Leu Ala Gly Glu Gly Glu Ala Cys Pro Leu Leu 
            660                 665                 670         


Gly Ser Pro Gly Ala Gly Arg Asn Ser Val Leu Phe Leu Pro Val Asp 
        675                 680                 685             


Pro Glu Asp Ser Pro Leu Gly Ser Ser Thr Pro Met Ala Ser Pro Asp 
    690                 695                 700                 


Leu Leu Pro Glu Asp Val Arg Glu His Leu Glu Gly Leu Met Leu Ser 
705                 710                 715                 720 


Leu Phe Glu Gln Ser Leu Ser Cys Gln Ala Gln Gly Gly Cys Ser Arg 
                725                 730                 735     


Pro Ala Met Val Leu Thr Asp Pro His Thr Pro Tyr Glu Glu Glu Gln 
            740                 745                 750         


Arg Gln Ser Val Gln Ser Asp Gln Gly Tyr Ile Ser Arg Ser Ser Pro 
        755                 760                 765             


Gln Pro Pro Glu Gly Leu Thr Glu Met Glu Glu Glu Glu Glu Glu Glu 
    770                 775                 780                 


Gln Asp Pro Gly Lys Pro Ala Leu Pro Leu Ser Pro Glu Asp Leu Glu 
785                 790                 795                 800 


Ser Leu Arg Ser Leu Gln Arg Gln Leu Leu Phe Arg Gln Leu Gln Lys 
                805                 810                 815     


Asn Ser Gly Trp Asp Thr Met Gly Ser Glu Ser Glu Gly Pro Ser Ala 
            820                 825                 830         


<210>  6908
<211>  330
<212>  PRT
<213>  Homo Sapiens

<400>  6908

Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro 
1               5                   10                  15      


Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His 
            20                  25                  30          


Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys 
        35                  40                  45              


Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr 
    50                  55                  60                  


His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys 
65                  70                  75                  80  


Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Ala Ser Leu 
                85                  90                  95      


Gln Ala Gln Val Val Leu Ser Phe Gln Ala Tyr Pro Thr Ala Arg Cys 
            100                 105                 110         


Val Leu Leu Glu Val Gln Val Pro Ala Ala Leu Val Gln Phe Gly Gln 
        115                 120                 125             


Ser Val Gly Ser Val Val Tyr Asp Cys Phe Glu Ala Ala Leu Gly Ser 
    130                 135                 140                 


Glu Val Arg Ile Trp Ser Tyr Thr Gln Pro Arg Tyr Glu Lys Glu Leu 
145                 150                 155                 160 


Asn His Thr Gln Gln Leu Pro Ala Leu Pro Trp Leu Asn Val Ser Ala 
                165                 170                 175     


Asp Gly Asp Asn Val His Leu Val Leu Asn Val Ser Glu Glu Gln His 
            180                 185                 190         


Phe Gly Leu Ser Leu Tyr Trp Asn Gln Val Gln Gly Pro Pro Lys Pro 
        195                 200                 205             


Arg Trp His Lys Asn Leu Thr Gly Pro Gln Ile Ile Thr Leu Asn His 
    210                 215                 220                 


Thr Asp Leu Val Pro Cys Leu Cys Ile Gln Val Trp Pro Leu Glu Pro 
225                 230                 235                 240 


Asp Ser Val Arg Thr Asn Ile Cys Pro Phe Arg Glu Asp Pro Arg Ala 
                245                 250                 255     


His Gln Asn Leu Trp Gln Ala Ala Arg Leu Gln Leu Leu Thr Leu Gln 
            260                 265                 270         


Ser Trp Leu Leu Asp Ala Pro Cys Ser Leu Pro Ala Glu Ala Ala Leu 
        275                 280                 285             


Cys Trp Arg Ala Pro Gly Gly Asp Pro Cys Gln Pro Leu Val Pro Pro 
    290                 295                 300                 


Leu Ser Trp Glu Asn Val Thr Val Asp Lys Val Leu Glu Phe Pro Leu 
305                 310                 315                 320 


Leu Lys Gly His Pro Asn Leu Cys Val Gln 
                325                 330 


<210>  6909
<211>  242
<212>  PRT
<213>  Homo Sapiens

<400>  6909

Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro 
1               5                   10                  15      


Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His 
            20                  25                  30          


Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys 
        35                  40                  45              


Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr 
    50                  55                  60                  


His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys 
65                  70                  75                  80  


Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Ala Ser Leu 
                85                  90                  95      


Gln Ala Gln Val Val Leu Ser Phe Gln Ala Tyr Pro Thr Ala Arg Cys 
            100                 105                 110         


Val Leu Leu Glu Val Gln Val Pro Ala Ala Leu Val Gln Phe Gly Gln 
        115                 120                 125             


Ser Val Gly Ser Val Val Tyr Asp Cys Phe Glu Ala Ala Leu Gly Ser 
    130                 135                 140                 


Glu Val Arg Ile Trp Ser Tyr Thr Gln Pro Arg Tyr Glu Lys Glu Leu 
145                 150                 155                 160 


Asn His Thr Gln Gln Leu Pro Ala Leu Pro Trp Leu Asn Val Ser Ala 
                165                 170                 175     


Asp Gly Asp Asn Val His Leu Val Leu Asn Val Ser Glu Glu Gln His 
            180                 185                 190         


Phe Gly Leu Ser Leu Tyr Trp Asn Gln Val Gln Gly Pro Pro Lys Pro 
        195                 200                 205             


Arg Trp His Lys Asn Leu Val Arg Pro Pro Pro Ser Gln Val His Ser 
    210                 215                 220                 


His Cys Arg Pro Met Pro Val Gln Arg Thr Gln Cys His Ile Arg Glu 
225                 230                 235                 240 


Asp Pro 
        


<210>  6910
<211>  416
<212>  PRT
<213>  Homo Sapiens

<400>  6910

Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro 
1               5                   10                  15      


Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His 
            20                  25                  30          


Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys 
        35                  40                  45              


Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr 
    50                  55                  60                  


His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys 
65                  70                  75                  80  


Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Ala Ser Leu 
                85                  90                  95      


Gln Ala Gln Val Val Leu Ser Phe Gln Ala Tyr Pro Thr Ala Arg Cys 
            100                 105                 110         


Val Leu Leu Glu Val Gln Val Pro Ala Ala Leu Val Gln Phe Gly Gln 
        115                 120                 125             


Ser Val Gly Ser Val Val Tyr Asp Cys Phe Glu Ala Ala Leu Gly Ser 
    130                 135                 140                 


Glu Val Arg Ile Trp Ser Tyr Thr Gln Pro Arg Tyr Glu Lys Glu Leu 
145                 150                 155                 160 


Asn His Thr Gln Gln Leu Pro Asp Cys Arg Gly Leu Glu Val Trp Asn 
                165                 170                 175     


Ser Ile Pro Ser Cys Trp Ala Leu Pro Trp Leu Asn Val Ser Ala Asp 
            180                 185                 190         


Gly Asp Asn Val His Leu Val Leu Asn Val Ser Glu Glu Gln His Phe 
        195                 200                 205             


Gly Leu Ser Leu Tyr Trp Asn Gln Val Gln Gly Pro Pro Lys Pro Arg 
    210                 215                 220                 


Trp His Lys Asn Leu Thr Gly Pro Gln Ile Ile Thr Leu Asn His Thr 
225                 230                 235                 240 


Asp Leu Val Pro Cys Leu Cys Ile Gln Val Trp Pro Leu Glu Pro Asp 
                245                 250                 255     


Ser Val Arg Thr Asn Ile Cys Pro Phe Arg Glu Asp Pro Arg Ala His 
            260                 265                 270         


Gln Asn Leu Trp Gln Ala Ala Arg Leu Gln Leu Leu Thr Leu Gln Ser 
        275                 280                 285             


Trp Leu Leu Asp Ala Pro Cys Ser Leu Pro Ala Glu Ala Ala Leu Cys 
    290                 295                 300                 


Trp Arg Ala Pro Gly Gly Asp Pro Cys Gln Pro Leu Val Pro Pro Leu 
305                 310                 315                 320 


Ser Trp Glu Asn Val Thr Val Asp Lys Val Leu Glu Phe Pro Leu Leu 
                325                 330                 335     


Lys Gly His Pro Asn Leu Cys Val Gln Val Asn Ser Ser Glu Lys Leu 
            340                 345                 350         


Gln Leu Gln Glu Cys Leu Trp Ala Asp Ser Leu Gly Pro Leu Lys Asp 
        355                 360                 365             


Asp Val Leu Leu Leu Glu Thr Arg Gly Pro Gln Asp Asn Arg Ser Leu 
    370                 375                 380                 


Cys Ala Leu Glu Pro Ser Gly Cys Thr Ser Leu Pro Ser Lys Ala Ser 
385                 390                 395                 400 


Thr Arg Ala Ala Arg Leu Gly Glu Tyr Leu Leu Gln Asp Leu Gln Ser 
                405                 410                 415     


<210>  6911
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  6911

Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro 
1               5                   10                  15      


Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His 
            20                  25                  30          


Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys 
        35                  40                  45              


Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr 
    50                  55                  60                  


His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys 
65                  70                  75                  80  


Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly Glu Gln 
                85                  90                  95      


Val Ile Leu 
            


<210>  6912
<211>  156
<212>  PRT
<213>  Homo Sapiens

<400>  6912

Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro 
1               5                   10                  15      


Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His 
            20                  25                  30          


Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys 
        35                  40                  45              


Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr 
    50                  55                  60                  


His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys 
65                  70                  75                  80  


Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp 
                85                  90                  95      


Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly 
            100                 105                 110         


Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser 
        115                 120                 125             


Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val 
    130                 135                 140                 


Pro Ala Ala Leu Val Gln Phe Gly Leu Cys Gly Ile 
145                 150                 155     


<210>  6913
<211>  705
<212>  PRT
<213>  Homo Sapiens

<400>  6913

Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro 
1               5                   10                  15      


Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His 
            20                  25                  30          


Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys 
        35                  40                  45              


Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr 
    50                  55                  60                  


His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys 
65                  70                  75                  80  


Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp 
                85                  90                  95      


Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly 
            100                 105                 110         


Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser 
        115                 120                 125             


Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val 
    130                 135                 140                 


Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr 
145                 150                 155                 160 


Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr 
                165                 170                 175     


Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro 
            180                 185                 190         


Ala Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu 
        195                 200                 205             


Val Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp 
    210                 215                 220                 


Asn Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr 
225                 230                 235                 240 


Gly Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu 
                245                 250                 255     


Cys Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile 
            260                 265                 270         


Cys Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala 
        275                 280                 285             


Ala Arg Leu Gln Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro 
    290                 295                 300                 


Cys Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly 
305                 310                 315                 320 


Asp Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr 
                325                 330                 335     


Val Asp Lys Val Leu Glu Phe Pro Leu Leu Lys Gly His Pro Asn Leu 
            340                 345                 350         


Cys Val Gln Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu 
        355                 360                 365             


Trp Ala Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu 
    370                 375                 380                 


Thr Arg Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser 
385                 390                 395                 400 


Gly Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu 
                405                 410                 415     


Gly Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu 
            420                 425                 430         


Trp Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr 
        435                 440                 445             


Ile His Lys Arg Trp Ala Leu Val Trp Leu Ala Cys Leu Leu Phe Ala 
    450                 455                 460                 


Ala Ala Leu Ser Leu Ile Leu Leu Leu Lys Lys Asp His Ala Lys Gly 
465                 470                 475                 480 


Trp Leu Arg Leu Leu Lys Gln Asp Val Arg Ser Gly Ala Ala Ala Arg 
                485                 490                 495     


Gly Arg Ala Ala Leu Leu Leu Tyr Ser Ala Asp Asp Ser Gly Phe Glu 
            500                 505                 510         


Arg Leu Val Gly Ala Leu Ala Ser Ala Leu Cys Gln Leu Pro Leu Arg 
        515                 520                 525             


Val Ala Val Asp Leu Trp Ser Arg Arg Glu Leu Ser Ala Gln Gly Pro 
    530                 535                 540                 


Val Ala Trp Phe His Ala Gln Arg Arg Gln Thr Leu Gln Glu Gly Gly 
545                 550                 555                 560 


Val Val Val Leu Leu Phe Ser Pro Gly Ala Val Ala Leu Cys Ser Glu 
                565                 570                 575     


Trp Leu Gln Asp Gly Val Ser Gly Pro Gly Ala His Gly Pro His Asp 
            580                 585                 590         


Ala Phe Arg Ala Ser Leu Ser Cys Val Leu Pro Asp Phe Leu Gln Gly 
        595                 600                 605             


Arg Ala Pro Gly Ser Tyr Val Gly Ala Cys Phe Asp Arg Leu Leu His 
    610                 615                 620                 


Pro Asp Ala Val Pro Ala Leu Phe Arg Thr Val Pro Val Phe Thr Leu 
625                 630                 635                 640 


Pro Ser Gln Leu Pro Asp Phe Leu Gly Ala Leu Gln Gln Pro Arg Ala 
                645                 650                 655     


Pro Arg Ser Gly Arg Leu Gln Glu Arg Ala Glu Gln Val Ser Arg Ala 
            660                 665                 670         


Leu Gln Pro Ala Leu Asp Ser Tyr Phe His Pro Pro Gly Thr Pro Ala 
        675                 680                 685             


Pro Gly Arg Gly Val Gly Pro Gly Ala Gly Pro Gly Ala Gly Asp Gly 
    690                 695                 700                 


Thr 
705 


<210>  6914
<211>  688
<212>  PRT
<213>  Homo Sapiens

<400>  6914

Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro 
1               5                   10                  15      


Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His 
            20                  25                  30          


Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys 
        35                  40                  45              


Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr 
    50                  55                  60                  


His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys 
65                  70                  75                  80  


Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp 
                85                  90                  95      


Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly 
            100                 105                 110         


Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser 
        115                 120                 125             


Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val 
    130                 135                 140                 


Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr 
145                 150                 155                 160 


Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr 
                165                 170                 175     


Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro 
            180                 185                 190         


Ala Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu 
        195                 200                 205             


Val Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp 
    210                 215                 220                 


Asn Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr 
225                 230                 235                 240 


Gly Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu 
                245                 250                 255     


Cys Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile 
            260                 265                 270         


Cys Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala 
        275                 280                 285             


Ala Arg Leu Gln Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro 
    290                 295                 300                 


Cys Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly 
305                 310                 315                 320 


Asp Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr 
                325                 330                 335     


Val Asp Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu Trp 
            340                 345                 350         


Ala Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu Thr 
        355                 360                 365             


Arg Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser Gly 
    370                 375                 380                 


Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu Gly 
385                 390                 395                 400 


Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu Trp 
                405                 410                 415     


Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile 
            420                 425                 430         


His Lys Arg Trp Ala Leu Val Trp Leu Ala Cys Leu Leu Phe Ala Ala 
        435                 440                 445             


Ala Leu Ser Leu Ile Leu Leu Leu Lys Lys Asp His Ala Lys Gly Trp 
    450                 455                 460                 


Leu Arg Leu Leu Lys Gln Asp Val Arg Ser Gly Ala Ala Ala Arg Gly 
465                 470                 475                 480 


Arg Ala Ala Leu Leu Leu Tyr Ser Ala Asp Asp Ser Gly Phe Glu Arg 
                485                 490                 495     


Leu Val Gly Ala Leu Ala Ser Ala Leu Cys Gln Leu Pro Leu Arg Val 
            500                 505                 510         


Ala Val Asp Leu Trp Ser Arg Arg Glu Leu Ser Ala Gln Gly Pro Val 
        515                 520                 525             


Ala Trp Phe His Ala Gln Arg Arg Gln Thr Leu Gln Glu Gly Gly Val 
    530                 535                 540                 


Val Val Leu Leu Phe Ser Pro Gly Ala Val Ala Leu Cys Ser Glu Trp 
545                 550                 555                 560 


Leu Gln Asp Gly Val Ser Gly Pro Gly Ala His Gly Pro His Asp Ala 
                565                 570                 575     


Phe Arg Ala Ser Leu Ser Cys Val Leu Pro Asp Phe Leu Gln Gly Arg 
            580                 585                 590         


Ala Pro Gly Ser Tyr Val Gly Ala Cys Phe Asp Arg Leu Leu His Pro 
        595                 600                 605             


Asp Ala Val Pro Ala Leu Phe Arg Thr Val Pro Val Phe Thr Leu Pro 
    610                 615                 620                 


Ser Gln Leu Pro Asp Phe Leu Gly Ala Leu Gln Gln Pro Arg Ala Pro 
625                 630                 635                 640 


Arg Ser Gly Arg Leu Gln Glu Arg Ala Glu Gln Val Ser Arg Ala Leu 
                645                 650                 655     


Gln Pro Ala Leu Asp Ser Tyr Phe His Pro Pro Gly Thr Pro Ala Pro 
            660                 665                 670         


Gly Arg Gly Val Gly Pro Gly Ala Gly Pro Gly Ala Gly Asp Gly Thr 
        675                 680                 685             


<210>  6915
<211>  690
<212>  PRT
<213>  Homo Sapiens

<400>  6915

Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro 
1               5                   10                  15      


Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His 
            20                  25                  30          


Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys 
        35                  40                  45              


Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr 
    50                  55                  60                  


His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys 
65                  70                  75                  80  


Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp 
                85                  90                  95      


Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly 
            100                 105                 110         


Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser 
        115                 120                 125             


Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val 
    130                 135                 140                 


Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr 
145                 150                 155                 160 


Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr 
                165                 170                 175     


Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro 
            180                 185                 190         


Asp Cys Arg Gly Leu Glu Val Trp Asn Ser Ile Pro Ser Cys Trp Ala 
        195                 200                 205             


Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu Val 
    210                 215                 220                 


Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp Asn 
225                 230                 235                 240 


Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr Gly 
                245                 250                 255     


Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu Cys 
            260                 265                 270         


Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile Cys 
        275                 280                 285             


Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala Ala 
    290                 295                 300                 


Arg Leu Gln Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro Cys 
305                 310                 315                 320 


Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly Asp 
                325                 330                 335     


Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr Val 
            340                 345                 350         


Asp Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu Trp Ala 
        355                 360                 365             


Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu Thr Arg 
    370                 375                 380                 


Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser Gly Cys 
385                 390                 395                 400 


Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu Gly Glu 
                405                 410                 415     


Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu Trp Asp 
            420                 425                 430         


Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile His 
        435                 440                 445             


Lys Arg Trp Ala Leu Val Trp Leu Ala Cys Leu Leu Phe Ala Ala Ala 
    450                 455                 460                 


Leu Ser Leu Ile Leu Leu Leu Lys Lys Asp His Ala Lys Ala Ala Ala 
465                 470                 475                 480 


Arg Gly Arg Ala Ala Leu Leu Leu Tyr Ser Ala Asp Asp Ser Gly Phe 
                485                 490                 495     


Glu Arg Leu Val Gly Ala Leu Ala Ser Ala Leu Cys Gln Leu Pro Leu 
            500                 505                 510         


Arg Val Ala Val Asp Leu Trp Ser Arg Arg Glu Leu Ser Ala Gln Gly 
        515                 520                 525             


Pro Val Ala Trp Phe His Ala Gln Arg Arg Gln Thr Leu Gln Glu Gly 
    530                 535                 540                 


Gly Val Val Val Leu Leu Phe Ser Pro Gly Ala Val Ala Leu Cys Ser 
545                 550                 555                 560 


Glu Trp Leu Gln Asp Gly Val Ser Gly Pro Gly Ala His Gly Pro His 
                565                 570                 575     


Asp Ala Phe Arg Ala Ser Leu Ser Cys Val Leu Pro Asp Phe Leu Gln 
            580                 585                 590         


Gly Arg Ala Pro Gly Ser Tyr Val Gly Ala Cys Phe Asp Arg Leu Leu 
        595                 600                 605             


His Pro Asp Ala Val Pro Ala Leu Phe Arg Thr Val Pro Val Phe Thr 
    610                 615                 620                 


Leu Pro Ser Gln Leu Pro Asp Phe Leu Gly Ala Leu Gln Gln Pro Arg 
625                 630                 635                 640 


Ala Pro Arg Ser Gly Arg Leu Gln Glu Arg Ala Glu Gln Val Ser Arg 
                645                 650                 655     


Ala Leu Gln Pro Ala Leu Asp Ser Tyr Phe His Pro Pro Gly Thr Pro 
            660                 665                 670         


Ala Pro Gly Arg Gly Val Gly Pro Gly Ala Gly Pro Gly Ala Gly Asp 
        675                 680                 685             


Gly Thr 
    690 


<210>  6916
<211>  720
<212>  PRT
<213>  Homo Sapiens

<400>  6916

Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro 
1               5                   10                  15      


Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His 
            20                  25                  30          


Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys 
        35                  40                  45              


Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr 
    50                  55                  60                  


His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys 
65                  70                  75                  80  


Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp 
                85                  90                  95      


Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly 
            100                 105                 110         


Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser 
        115                 120                 125             


Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val 
    130                 135                 140                 


Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr 
145                 150                 155                 160 


Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr 
                165                 170                 175     


Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro 
            180                 185                 190         


Asp Cys Arg Gly Leu Glu Val Trp Asn Ser Ile Pro Ser Cys Trp Ala 
        195                 200                 205             


Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu Val 
    210                 215                 220                 


Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp Asn 
225                 230                 235                 240 


Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr Gly 
                245                 250                 255     


Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu Cys 
            260                 265                 270         


Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile Cys 
        275                 280                 285             


Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala Ala 
    290                 295                 300                 


Arg Leu Gln Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro Cys 
305                 310                 315                 320 


Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly Asp 
                325                 330                 335     


Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr Val 
            340                 345                 350         


Asp Lys Val Leu Glu Phe Pro Leu Leu Lys Gly His Pro Asn Leu Cys 
        355                 360                 365             


Val Gln Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu Trp 
    370                 375                 380                 


Ala Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu Thr 
385                 390                 395                 400 


Arg Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser Gly 
                405                 410                 415     


Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu Gly 
            420                 425                 430         


Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu Trp 
        435                 440                 445             


Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile 
    450                 455                 460                 


His Lys Arg Trp Ala Leu Val Trp Leu Ala Cys Leu Leu Phe Ala Ala 
465                 470                 475                 480 


Ala Leu Ser Leu Ile Leu Leu Leu Lys Lys Asp His Ala Lys Gly Trp 
                485                 490                 495     


Leu Arg Leu Leu Lys Gln Asp Val Arg Ser Gly Ala Ala Ala Arg Gly 
            500                 505                 510         


Arg Ala Ala Leu Leu Leu Tyr Ser Ala Asp Asp Ser Gly Phe Glu Arg 
        515                 520                 525             


Leu Val Gly Ala Leu Ala Ser Ala Leu Cys Gln Leu Pro Leu Arg Val 
    530                 535                 540                 


Ala Val Asp Leu Trp Ser Arg Arg Glu Leu Ser Ala Gln Gly Pro Val 
545                 550                 555                 560 


Ala Trp Phe His Ala Gln Arg Arg Gln Thr Leu Gln Glu Gly Gly Val 
                565                 570                 575     


Val Val Leu Leu Phe Ser Pro Gly Ala Val Ala Leu Cys Ser Glu Trp 
            580                 585                 590         


Leu Gln Asp Gly Val Ser Gly Pro Gly Ala His Gly Pro His Asp Ala 
        595                 600                 605             


Phe Arg Ala Ser Leu Ser Cys Val Leu Pro Asp Phe Leu Gln Gly Arg 
    610                 615                 620                 


Ala Pro Gly Ser Tyr Val Gly Ala Cys Phe Asp Arg Leu Leu His Pro 
625                 630                 635                 640 


Asp Ala Val Pro Ala Leu Phe Arg Thr Val Pro Val Phe Thr Leu Pro 
                645                 650                 655     


Ser Gln Leu Pro Asp Phe Leu Gly Ala Leu Gln Gln Pro Arg Ala Pro 
            660                 665                 670         


Arg Ser Gly Arg Leu Gln Glu Arg Ala Glu Gln Val Ser Arg Ala Leu 
        675                 680                 685             


Gln Pro Ala Leu Asp Ser Tyr Phe His Pro Pro Gly Thr Pro Ala Pro 
    690                 695                 700                 


Gly Arg Gly Val Gly Pro Gly Ala Gly Pro Gly Ala Gly Asp Gly Thr 
705                 710                 715                 720 


<210>  6917
<211>  707
<212>  PRT
<213>  Homo Sapiens

<400>  6917

Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro 
1               5                   10                  15      


Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His 
            20                  25                  30          


Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys 
        35                  40                  45              


Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr 
    50                  55                  60                  


His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys 
65                  70                  75                  80  


Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp 
                85                  90                  95      


Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly 
            100                 105                 110         


Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser 
        115                 120                 125             


Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val 
    130                 135                 140                 


Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr 
145                 150                 155                 160 


Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr 
                165                 170                 175     


Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro 
            180                 185                 190         


Asp Cys Arg Gly Leu Glu Val Trp Asn Ser Ile Pro Ser Cys Trp Ala 
        195                 200                 205             


Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu Val 
    210                 215                 220                 


Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp Asn 
225                 230                 235                 240 


Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr Gly 
                245                 250                 255     


Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu Cys 
            260                 265                 270         


Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile Cys 
        275                 280                 285             


Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala Ala 
    290                 295                 300                 


Arg Leu Gln Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro Cys 
305                 310                 315                 320 


Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly Asp 
                325                 330                 335     


Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr Val 
            340                 345                 350         


Asp Lys Val Leu Glu Phe Pro Leu Leu Lys Gly His Pro Asn Leu Cys 
        355                 360                 365             


Val Gln Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu Trp 
    370                 375                 380                 


Ala Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu Thr 
385                 390                 395                 400 


Arg Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser Gly 
                405                 410                 415     


Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu Gly 
            420                 425                 430         


Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu Trp 
        435                 440                 445             


Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile 
    450                 455                 460                 


His Lys Arg Trp Ala Leu Val Trp Leu Ala Cys Leu Leu Phe Ala Ala 
465                 470                 475                 480 


Ala Leu Ser Leu Ile Leu Leu Leu Lys Lys Asp His Ala Lys Ala Ala 
                485                 490                 495     


Ala Arg Gly Arg Ala Ala Leu Leu Leu Tyr Ser Ala Asp Asp Ser Gly 
            500                 505                 510         


Phe Glu Arg Leu Val Gly Ala Leu Ala Ser Ala Leu Cys Gln Leu Pro 
        515                 520                 525             


Leu Arg Val Ala Val Asp Leu Trp Ser Arg Arg Glu Leu Ser Ala Gln 
    530                 535                 540                 


Gly Pro Val Ala Trp Phe His Ala Gln Arg Arg Gln Thr Leu Gln Glu 
545                 550                 555                 560 


Gly Gly Val Val Val Leu Leu Phe Ser Pro Gly Ala Val Ala Leu Cys 
                565                 570                 575     


Ser Glu Trp Leu Gln Asp Gly Val Ser Gly Pro Gly Ala His Gly Pro 
            580                 585                 590         


His Asp Ala Phe Arg Ala Ser Leu Ser Cys Val Leu Pro Asp Phe Leu 
        595                 600                 605             


Gln Gly Arg Ala Pro Gly Ser Tyr Val Gly Ala Cys Phe Asp Arg Leu 
    610                 615                 620                 


Leu His Pro Asp Ala Val Pro Ala Leu Phe Arg Thr Val Pro Val Phe 
625                 630                 635                 640 


Thr Leu Pro Ser Gln Leu Pro Asp Phe Leu Gly Ala Leu Gln Gln Pro 
                645                 650                 655     


Arg Ala Pro Arg Ser Gly Arg Leu Gln Glu Arg Ala Glu Gln Val Ser 
            660                 665                 670         


Arg Ala Leu Gln Pro Ala Leu Asp Ser Tyr Phe His Pro Pro Gly Thr 
        675                 680                 685             


Pro Ala Pro Gly Arg Gly Val Gly Pro Gly Ala Gly Pro Gly Ala Gly 
    690                 695                 700                 


Asp Gly Thr 
705         


<210>  6918
<211>  98
<212>  PRT
<213>  Homo Sapiens

<400>  6918

Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro 
1               5                   10                  15      


Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His 
            20                  25                  30          


Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys 
        35                  40                  45              


Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr 
    50                  55                  60                  


His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys 
65                  70                  75                  80  


Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly Leu Cys 
                85                  90                  95      


Gly Ile 
        


<210>  6919
<211>  123
<212>  PRT
<213>  Homo Sapiens

<400>  6919

Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro 
1               5                   10                  15      


Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His 
            20                  25                  30          


Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys 
        35                  40                  45              


Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr 
    50                  55                  60                  


His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys 
65                  70                  75                  80  


Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly Leu Pro 
                85                  90                  95      


Tyr Cys Pro Leu Arg Pro Ala Gly Gly Ala Ser Ala Cys Cys Pro Cys 
            100                 105                 110         


Ala Val Trp Ser Val Cys Gly Leu Cys Gly Ile 
        115                 120             


<210>  6920
<211>  91
<212>  PRT
<213>  Homo Sapiens

<400>  6920

Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro 
1               5                   10                  15      


Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His 
            20                  25                  30          


Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Gly Ala Thr Lys Phe Trp 
        35                  40                  45              


Ala Trp Asn Ser Phe Ser Ser His Pro Leu Leu His Thr Gln Thr Val 
    50                  55                  60                  


Thr Tyr Ser Ala Cys Leu Gly Thr Ser Cys Leu Leu Arg Ala Pro Cys 
65                  70                  75                  80  


Trp Arg Leu Arg Thr Cys Arg Gln Ser Trp Cys 
                85                  90      


<210>  6921
<211>  70
<212>  PRT
<213>  Homo Sapiens

<400>  6921

Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro 
1               5                   10                  15      


Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His 
            20                  25                  30          


Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Val Thr Tyr Ser Ala Cys 
        35                  40                  45              


Leu Gly Thr Ser Cys Leu Leu Arg Ala Pro Cys Trp Arg Leu Arg Thr 
    50                  55                  60                  


Cys Arg Gln Ser Trp Cys 
65                  70  


<210>  6922
<211>  44
<212>  PRT
<213>  Homo Sapiens

<400>  6922

Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro 
1               5                   10                  15      


Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His 
            20                  25                  30          


Cys Ser Pro Asn Cys Pro Val Trp Ser Val Trp Cys 
        35                  40                  


<210>  6923
<211>  791
<212>  PRT
<213>  Homo Sapiens

<400>  6923

Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro 
1               5                   10                  15      


Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His 
            20                  25                  30          


Cys Ser Pro Val Ser Leu Glu Pro Trp Gly Asp Glu Glu Arg Leu Arg 
        35                  40                  45              


Val Gln Phe Leu Ala Gln Gln Ser Leu Ser Leu Ala Pro Val Thr Ala 
    50                  55                  60                  


Ala Thr Ala Arg Thr Ala Leu Ser Gly Leu Ser Gly Ala Asp Gly Arg 
65                  70                  75                  80  


Arg Glu Glu Arg Gly Arg Gly Lys Ser Trp Val Cys Leu Ser Leu Gly 
                85                  90                  95      


Gly Ser Gly Asn Thr Glu Pro Gln Lys Lys Gly Leu Ser Cys Arg Leu 
            100                 105                 110         


Trp Asp Ser Asp Ile Leu Cys Leu Pro Gly Asp Ile Val Pro Ala Pro 
        115                 120                 125             


Gly Pro Val Leu Ala Pro Thr His Leu Gln Thr Glu Leu Val Leu Arg 
    130                 135                 140                 


Cys Gln Lys Glu Thr Asp Cys Asp Leu Cys Leu Arg Val Ala Val His 
145                 150                 155                 160 


Leu Ala Val His Gly His Trp Glu Glu Pro Glu Asp Glu Glu Lys Phe 
                165                 170                 175     


Gly Gly Ala Ala Asp Ser Gly Val Glu Glu Pro Arg Asn Ala Ser Leu 
            180                 185                 190         


Gln Ala Gln Val Val Leu Ser Phe Gln Ala Tyr Pro Thr Ala Arg Cys 
        195                 200                 205             


Val Leu Leu Glu Val Gln Val Pro Ala Ala Leu Val Gln Phe Gly Gln 
    210                 215                 220                 


Ser Val Gly Ser Val Val Tyr Asp Cys Phe Glu Ala Ala Leu Gly Ser 
225                 230                 235                 240 


Glu Val Arg Ile Trp Ser Tyr Thr Gln Pro Arg Tyr Glu Lys Glu Leu 
                245                 250                 255     


Asn His Thr Gln Gln Leu Pro Asp Cys Arg Gly Leu Glu Val Trp Asn 
            260                 265                 270         


Ser Ile Pro Ser Cys Trp Ala Leu Pro Trp Leu Asn Val Ser Ala Asp 
        275                 280                 285             


Gly Asp Asn Val His Leu Val Leu Asn Val Ser Glu Glu Gln His Phe 
    290                 295                 300                 


Gly Leu Ser Leu Tyr Trp Asn Gln Val Gln Gly Pro Pro Lys Pro Arg 
305                 310                 315                 320 


Trp His Lys Asn Leu Thr Gly Pro Gln Ile Ile Thr Leu Asn His Thr 
                325                 330                 335     


Asp Leu Val Pro Cys Leu Cys Ile Gln Val Trp Pro Leu Glu Pro Asp 
            340                 345                 350         


Ser Val Arg Thr Asn Ile Cys Pro Phe Arg Glu Asp Pro Arg Ala His 
        355                 360                 365             


Gln Asn Leu Trp Gln Ala Ala Arg Leu Gln Leu Leu Thr Leu Gln Ser 
    370                 375                 380                 


Trp Leu Leu Asp Ala Pro Cys Ser Leu Pro Ala Glu Ala Ala Leu Cys 
385                 390                 395                 400 


Trp Arg Ala Pro Gly Gly Asp Pro Cys Gln Pro Leu Val Pro Pro Leu 
                405                 410                 415     


Ser Trp Glu Asn Val Thr Val Asp Lys Val Leu Glu Phe Pro Leu Leu 
            420                 425                 430         


Lys Gly His Pro Asn Leu Cys Val Gln Val Asn Ser Ser Glu Lys Leu 
        435                 440                 445             


Gln Leu Gln Glu Cys Leu Trp Ala Asp Ser Leu Gly Pro Leu Lys Asp 
    450                 455                 460                 


Asp Val Leu Leu Leu Glu Thr Arg Gly Pro Gln Asp Asn Arg Ser Leu 
465                 470                 475                 480 


Cys Ala Leu Glu Pro Ser Gly Cys Thr Ser Leu Pro Ser Lys Ala Ser 
                485                 490                 495     


Thr Arg Ala Ala Arg Leu Gly Glu Tyr Leu Leu Gln Asp Leu Gln Ser 
            500                 505                 510         


Gly Gln Cys Leu Gln Leu Trp Asp Asp Asp Leu Gly Ala Leu Trp Ala 
        515                 520                 525             


Cys Pro Met Asp Lys Tyr Ile His Lys Arg Trp Ala Leu Val Trp Leu 
    530                 535                 540                 


Ala Cys Leu Leu Phe Ala Ala Ala Leu Ser Leu Ile Leu Leu Leu Lys 
545                 550                 555                 560 


Lys Asp His Ala Lys Gly Trp Leu Arg Leu Leu Lys Gln Asp Val Arg 
                565                 570                 575     


Ser Gly Ala Ala Ala Arg Gly Arg Ala Ala Leu Leu Leu Tyr Ser Ala 
            580                 585                 590         


Asp Asp Ser Gly Phe Glu Arg Leu Val Gly Ala Leu Ala Ser Ala Leu 
        595                 600                 605             


Cys Gln Leu Pro Leu Arg Val Ala Val Asp Leu Trp Ser Arg Arg Glu 
    610                 615                 620                 


Leu Ser Ala Gln Gly Pro Val Ala Trp Phe His Ala Gln Arg Arg Gln 
625                 630                 635                 640 


Thr Leu Gln Glu Gly Gly Val Val Val Leu Leu Phe Ser Pro Gly Ala 
                645                 650                 655     


Val Ala Leu Cys Ser Glu Trp Leu Gln Asp Gly Val Ser Gly Pro Gly 
            660                 665                 670         


Ala His Gly Pro His Asp Ala Phe Arg Ala Ser Leu Ser Cys Val Leu 
        675                 680                 685             


Pro Asp Phe Leu Gln Gly Arg Ala Pro Gly Ser Tyr Val Gly Ala Cys 
    690                 695                 700                 


Phe Asp Arg Leu Leu His Pro Asp Ala Val Pro Ala Leu Phe Arg Thr 
705                 710                 715                 720 


Val Pro Val Phe Thr Leu Pro Ser Gln Leu Pro Asp Phe Leu Gly Ala 
                725                 730                 735     


Leu Gln Gln Pro Arg Ala Pro Arg Ser Gly Arg Leu Gln Glu Arg Ala 
            740                 745                 750         


Glu Gln Val Ser Arg Ala Leu Gln Pro Ala Leu Asp Ser Tyr Phe His 
        755                 760                 765             


Pro Pro Gly Thr Pro Ala Pro Gly Arg Gly Val Gly Pro Gly Ala Gly 
    770                 775                 780                 


Pro Gly Ala Gly Asp Gly Thr 
785                 790     


<210>  6924
<211>  173
<212>  PRT
<213>  Homo Sapiens

<400>  6924

Met Gly Ser Ser Arg Leu Ala Ala Leu Leu Leu Pro Leu Leu Leu Ile 
1               5                   10                  15      


Val Ile Asp Leu Ser Asp Ser Ala Gly Ile Gly Phe Arg His Leu Pro 
            20                  25                  30          


His Trp Asn Thr Arg Cys Pro Leu Ala Ser His Thr Asp Asp Ser Phe 
        35                  40                  45              


Thr Gly Leu Gln Arg Gly Leu Phe His Leu Leu Val Gln Lys Ser Lys 
    50                  55                  60                  


Lys Ser Ser Thr Phe Lys Phe Tyr Arg Arg His Lys Met Pro Ala Pro 
65                  70                  75                  80  


Ala Gln Arg Lys Leu Leu Pro Arg Arg His Leu Ser Glu Lys Ser His 
                85                  90                  95      


His Ile Ser Ile Pro Ser Pro Asp Ile Ser His Lys Gly Leu Arg Ser 
            100                 105                 110         


Lys Arg Thr Gln Pro Ser Asp Pro Glu Thr Trp Glu Ser Leu Pro Arg 
        115                 120                 125             


Leu Asp Ser Gln Arg His Gly Gly Pro Glu Phe Ser Phe Asp Leu Leu 
    130                 135                 140                 


Pro Glu Ala Arg Ala Ile Arg Val Thr Ile Ser Ser Gly Pro Glu Val 
145                 150                 155                 160 


Ser Val Arg Leu Cys His Gln Trp Ala Leu Glu Cys Glu 
                165                 170             


<210>  6925
<211>  667
<212>  PRT
<213>  Homo Sapiens

<400>  6925

Met Gly Ser Ser Arg Leu Ala Ala Leu Leu Leu Pro Leu Leu Leu Ile 
1               5                   10                  15      


Val Ile Asp Leu Ser Asp Ser Ala Gly Ile Gly Phe Arg His Leu Pro 
            20                  25                  30          


His Trp Asn Thr Arg Cys Pro Leu Ala Ser His Thr Asp Asp Ser Phe 
        35                  40                  45              


Thr Gly Ser Ser Ala Tyr Ile Pro Cys Arg Thr Trp Trp Ala Leu Phe 
    50                  55                  60                  


Ser Thr Lys Pro Trp Cys Val Arg Val Trp His Cys Ser Arg Cys Leu 
65                  70                  75                  80  


Cys Gln His Leu Leu Ser Gly Gly Ser Gly Leu Gln Arg Gly Leu Phe 
                85                  90                  95      


His Leu Leu Val Gln Lys Ser Lys Lys Ser Ser Thr Phe Lys Phe Tyr 
            100                 105                 110         


Arg Arg His Lys Met Pro Ala Pro Ala Gln Arg Lys Leu Leu Pro Arg 
        115                 120                 125             


Arg His Leu Ser Glu Lys Ser His His Ile Ser Ile Pro Ser Pro Asp 
    130                 135                 140                 


Ile Ser His Lys Gly Leu Arg Ser Lys Arg Thr Gln Pro Ser Asp Pro 
145                 150                 155                 160 


Glu Thr Trp Glu Ser Leu Pro Arg Leu Asp Ser Gln Arg His Gly Gly 
                165                 170                 175     


Pro Glu Phe Ser Phe Asp Leu Leu Pro Glu Ala Arg Ala Ile Arg Val 
            180                 185                 190         


Thr Ile Ser Ser Gly Pro Glu Val Ser Val Arg Leu Cys His Gln Trp 
        195                 200                 205             


Ala Leu Glu Cys Glu Glu Leu Ser Ser Pro Tyr Asp Val Gln Lys Ile 
    210                 215                 220                 


Val Ser Gly Gly His Thr Val Glu Leu Pro Tyr Glu Phe Leu Leu Pro 
225                 230                 235                 240 


Cys Leu Cys Ile Glu Ala Ser Tyr Leu Gln Glu Asp Thr Val Arg Arg 
                245                 250                 255     


Lys Lys Cys Pro Phe Gln Ser Trp Pro Glu Ala Tyr Gly Ser Asp Phe 
            260                 265                 270         


Trp Lys Ser Val His Phe Thr Asp Tyr Ser Gln His Thr Gln Met Val 
        275                 280                 285             


Met Ala Leu Thr Leu Arg Cys Pro Leu Lys Leu Glu Ala Ala Leu Cys 
    290                 295                 300                 


Gln Arg His Asp Trp His Thr Leu Cys Lys Asp Leu Pro Asn Ala Thr 
305                 310                 315                 320 


Ala Arg Glu Ser Asp Gly Trp Tyr Val Leu Glu Lys Val Asp Leu His 
                325                 330                 335     


Pro Gln Leu Cys Phe Lys Phe Ser Phe Gly Asn Ser Ser His Val Glu 
            340                 345                 350         


Cys Pro His Gln Thr Gly Ser Leu Thr Ser Trp Asn Val Ser Met Asp 
        355                 360                 365             


Thr Gln Ala Gln Gln Leu Ile Leu His Phe Ser Ser Arg Met His Ala 
    370                 375                 380                 


Thr Phe Ser Ala Ala Trp Ser Leu Pro Gly Leu Gly Gln Asp Thr Leu 
385                 390                 395                 400 


Val Pro Pro Val Tyr Thr Val Ser Gln Ala Arg Gly Ser Ser Pro Val 
                405                 410                 415     


Ser Leu Asp Leu Ile Ile Pro Phe Leu Arg Pro Gly Cys Cys Val Leu 
            420                 425                 430         


Val Trp Arg Ser Asp Val Gln Phe Ala Trp Lys His Leu Leu Cys Pro 
        435                 440                 445             


Asp Val Ser Tyr Arg His Leu Gly Leu Leu Ile Leu Ala Leu Leu Ala 
    450                 455                 460                 


Leu Leu Thr Leu Leu Gly Val Val Leu Ala Leu Thr Cys Arg Arg Pro 
465                 470                 475                 480 


Gln Ser Gly Pro Gly Pro Ala Arg Pro Val Leu Leu Leu His Ala Ala 
                485                 490                 495     


Asp Ser Glu Ala Gln Arg Arg Leu Val Gly Ala Leu Ala Glu Leu Leu 
            500                 505                 510         


Arg Ala Ala Leu Gly Gly Gly Arg Asp Val Ile Val Asp Leu Trp Glu 
        515                 520                 525             


Gly Arg His Val Ala Arg Val Gly Pro Leu Pro Trp Leu Trp Ala Ala 
    530                 535                 540                 


Arg Thr Arg Val Ala Arg Glu Gln Gly Thr Val Leu Leu Leu Trp Ser 
545                 550                 555                 560 


Gly Ala Asp Leu Arg Pro Val Ser Gly Pro Asp Pro Arg Ala Ala Pro 
                565                 570                 575     


Leu Leu Ala Leu Leu His Ala Ala Pro Arg Pro Leu Leu Leu Leu Ala 
            580                 585                 590         


Tyr Phe Ser Arg Leu Cys Ala Lys Gly Asp Ile Pro Pro Pro Leu Arg 
        595                 600                 605             


Ala Leu Pro Arg Tyr Arg Leu Leu Arg Asp Leu Pro Arg Leu Leu Arg 
    610                 615                 620                 


Ala Leu Asp Ala Arg Pro Phe Ala Glu Ala Thr Ser Trp Gly Arg Leu 
625                 630                 635                 640 


Gly Ala Arg Gln Arg Arg Gln Ser Arg Leu Glu Leu Cys Ser Arg Leu 
                645                 650                 655     


Glu Arg Glu Ala Ala Arg Leu Ala Asp Leu Gly 
            660                 665         


<210>  6926
<211>  533
<212>  PRT
<213>  Homo Sapiens

<400>  6926

Met Gly Ser Ser Arg Leu Ala Ala Leu Leu Leu Pro Leu Leu Leu Ile 
1               5                   10                  15      


Val Ile Asp Leu Ser Asp Ser Ala Gly Ile Gly Phe Arg His Leu Pro 
            20                  25                  30          


His Trp Asn Thr Arg Cys Pro Leu Ala Ser His Thr Asp Asp Ser Phe 
        35                  40                  45              


Thr Gly Ser Ser Ala Tyr Ile Pro Cys Arg Thr Trp Trp Ala Leu Phe 
    50                  55                  60                  


Ser Thr Lys Pro Trp Cys Val Arg Val Trp His Cys Ser Arg Cys Leu 
65                  70                  75                  80  


Cys Gln His Leu Leu Ser Gly Gly Ser Gly Leu Gln Arg Gly Leu Phe 
                85                  90                  95      


His Leu Leu Val Gln Lys Ser Lys Lys Ser Ser Thr Phe Lys Phe Tyr 
            100                 105                 110         


Arg Arg His Lys Met Pro Ala Pro Ala Gln Arg Lys Leu Leu Pro Arg 
        115                 120                 125             


Arg His Leu Ser Glu Lys Ser His His Ile Ser Ile Pro Ser Pro Asp 
    130                 135                 140                 


Ile Ser His Lys Gly Leu Arg Ser Lys Arg Thr Gln Pro Ser Asp Pro 
145                 150                 155                 160 


Glu Thr Trp Glu Ser Leu Pro Arg Leu Asp Ser Gln Arg His Gly Gly 
                165                 170                 175     


Pro Glu Phe Ser Phe Asp Leu Leu Pro Glu Ala Arg Ala Ile Arg Val 
            180                 185                 190         


Thr Ile Ser Ser Gly Pro Glu Val Ser Val Arg Leu Cys His Gln Trp 
        195                 200                 205             


Ala Leu Glu Cys Glu Glu Leu Ser Ser Pro Tyr Asp Val Gln Lys Ile 
    210                 215                 220                 


Val Ser Gly Gly His Thr Val Glu Leu Pro Tyr Glu Phe Leu Leu Pro 
225                 230                 235                 240 


Cys Leu Cys Ile Glu Ala Ser Tyr Leu Gln Glu Asp Thr Val Arg Arg 
                245                 250                 255     


Lys Lys Cys Pro Phe Gln Ser Trp Pro Glu Ala Tyr Gly Ser Asp Phe 
            260                 265                 270         


Trp Lys Ser Val His Phe Thr Asp Tyr Ser Gln His Thr Gln Met Val 
        275                 280                 285             


Met Ala Leu Thr Leu Arg Cys Pro Leu Lys Leu Glu Ala Ala Leu Cys 
    290                 295                 300                 


Gln Arg His Asp Trp His Thr Leu Cys Lys Asp Leu Pro Asn Ala Thr 
305                 310                 315                 320 


Ala Arg Glu Ser Asp Gly Trp Tyr Val Leu Glu Lys Val Asp Leu His 
                325                 330                 335     


Pro Gln Leu Cys Phe Lys Phe Ser Phe Gly Asn Ser Ser His Val Glu 
            340                 345                 350         


Cys Pro His Gln Thr Gly Ser Leu Thr Ser Trp Asn Val Ser Met Asp 
        355                 360                 365             


Thr Gln Ala Gln Gln Leu Ile Leu His Phe Ser Ser Arg Met His Ala 
    370                 375                 380                 


Thr Phe Ser Ala Ala Trp Ser Leu Pro Gly Leu Gly Gln Asp Thr Leu 
385                 390                 395                 400 


Val Pro Pro Val Tyr Thr Val Ser Gln Ala Arg Gly Ser Ser Pro Val 
                405                 410                 415     


Ser Leu Asp Leu Ile Ile Pro Phe Leu Arg Pro Gly Cys Cys Val Leu 
            420                 425                 430         


Leu His Ala Ser Leu Ser Ser Pro Gly Gly Glu Asp Ala Trp Leu Ile 
        435                 440                 445             


Gly Val Gly Gly Ser Val Pro Ser Gly Val Ala Val Arg Cys Pro Val 
    450                 455                 460                 


Cys Leu Glu Ala Pro Leu Val Ser Gly Cys Leu Leu Gln Thr Pro Gly 
465                 470                 475                 480 


Ala Leu Asp Pro Gly Thr Ala Gly Pro Pro His Pro Thr Gly Cys Cys 
                485                 490                 495     


Ser Gly Pro His Leu Pro Ala Pro Thr Val Arg Pro Gly Pro Ser Ala 
            500                 505                 510         


Ala Ser Ala Pro Pro Ala Arg Gly Gly Leu Gly Gly Ala Ala Ala Pro 
        515                 520                 525             


Gly Gly Ser Ala Gly 
    530             


<210>  6927
<211>  186
<212>  PRT
<213>  Homo Sapiens

<400>  6927

Met Gly Ser Ser Arg Leu Ala Ala Leu Leu Leu Pro Leu Leu Leu Ile 
1               5                   10                  15      


Val Ile Asp Leu Ser Asp Ser Ala Gly Ile Gly Phe Arg His Leu Pro 
            20                  25                  30          


His Trp Asn Thr Arg Cys Pro Leu Ala Ser His Thr Glu Val Leu Pro 
        35                  40                  45              


Ile Ser Leu Ala Ala Pro Gly Gly Pro Ser Ser Pro Gln Ser Leu Gly 
    50                  55                  60                  


Val Cys Glu Ser Gly Thr Val Pro Ala Val Cys Ala Ser Ile Cys Cys 
65                  70                  75                  80  


Gln Val Ala Gln Val Phe Asn Gly Ala Ser Ser Thr Ser Trp Cys Arg 
                85                  90                  95      


Asn Pro Lys Ser Leu Pro His Ser Ser Ser Ile Gly Asp Thr Arg Cys 
            100                 105                 110         


Gln His Leu Leu Arg Gly Ser Cys Cys Leu Val Val Thr Cys Leu Arg 
        115                 120                 125             


Arg Ala Ile Thr Phe Pro Ser Pro Pro Gln Thr Ser Pro Thr Arg Asp 
    130                 135                 140                 


Phe Ala Leu Lys Gly Pro Asn Leu Arg Ile Gln Arg His Gly Lys Val 
145                 150                 155                 160 


Phe Pro Asp Trp Thr His Lys Gly Met Glu Asp Pro Ser Ser Pro Leu 
                165                 170                 175     


Ile Cys Cys Leu Arg Pro Gly Leu Phe Gly 
            180                 185     


<210>  6928
<211>  190
<212>  PRT
<213>  Homo Sapiens

<400>  6928

Met Gly Ser Ser Arg Leu Ala Ala Leu Leu Leu Pro Leu Leu Leu Ile 
1               5                   10                  15      


Val Ile Asp Leu Ser Asp Ser Ala Gly Ile Gly Phe Arg His Leu Pro 
            20                  25                  30          


His Trp Asn Thr Arg Cys Pro Leu Ala Ser His Thr Arg Lys Leu Leu 
        35                  40                  45              


Pro Arg Arg His Leu Ser Glu Lys Ser His His Ile Ser Ile Pro Ser 
    50                  55                  60                  


Pro Asp Ile Ser His Lys Gly Leu Arg Ser Lys Arg Thr Gln Pro Ser 
65                  70                  75                  80  


Asp Pro Glu Thr Trp Glu Ser Leu Pro Arg Leu Asp Ser Gln Arg His 
                85                  90                  95      


Gly Gly Pro Glu Phe Ser Phe Asp Leu Leu Pro Glu Ala Arg Ala Ile 
            100                 105                 110         


Arg Val Thr Ile Ser Ser Gly Pro Glu Val Ser Val Arg Leu Cys His 
        115                 120                 125             


Gln Trp Ala Leu Glu Cys Glu Glu Leu Ser Ser Pro Tyr Asp Val Gln 
    130                 135                 140                 


Lys Ile Val Ser Gly Gly His Thr Val Glu Leu Pro Tyr Glu Phe Leu 
145                 150                 155                 160 


Leu Pro Cys Leu Cys Ile Glu Met Ala Arg Thr Ser Gly Ser Gln Cys 
                165                 170                 175     


Thr Ser Leu Thr Thr Ala Ser Thr Leu Arg Trp Ser Trp Pro 
            180                 185                 190 


<210>  6929
<211>  146
<212>  PRT
<213>  Homo Sapiens

<400>  6929

Met Gly Ser Ser Arg Leu Ala Ala Leu Leu Leu Pro Leu Leu Leu Ile 
1               5                   10                  15      


Val Ile Asp Leu Ser Asp Ser Ala Gly Ile Gly Phe Arg His Leu Pro 
            20                  25                  30          


His Trp Asn Thr Arg Cys Pro Leu Ala Ser His Thr Val Phe Asn Gly 
        35                  40                  45              


Ala Ser Ser Thr Ser Trp Cys Arg Asn Pro Lys Ser Leu Pro His Ser 
    50                  55                  60                  


Ser Ser Ile Gly Asp Thr Arg Cys Gln His Leu Leu Arg Gly Ser Cys 
65                  70                  75                  80  


Cys Leu Val Val Thr Cys Leu Arg Arg Ala Ile Thr Phe Pro Ser Pro 
                85                  90                  95      


Pro Gln Thr Ser Pro Thr Arg Asp Phe Ala Leu Lys Gly Pro Asn Leu 
            100                 105                 110         


Arg Ile Gln Arg His Gly Lys Val Phe Pro Asp Trp Thr His Lys Gly 
        115                 120                 125             


Met Glu Asp Pro Ser Ser Pro Leu Ile Cys Cys Leu Arg Pro Gly Leu 
    130                 135                 140                 


Phe Gly 
145     


<210>  6930
<211>  700
<212>  PRT
<213>  Homo Sapiens

<400>  6930

Met Leu Ala Pro Phe Leu Leu Leu Leu Thr His Ser Arg Ser Pro Leu 
1               5                   10                  15      


Ser Phe Arg Pro Cys Ser His Val Pro Gly Ala Leu Ile Ala Gln Lys 
            20                  25                  30          


Pro Met Gly Ser Ser Arg Leu Ala Ala Leu Leu Leu Pro Leu Leu Leu 
        35                  40                  45              


Ile Val Ile Asp Leu Ser Asp Ser Ala Gly Ile Gly Phe Arg His Leu 
    50                  55                  60                  


Pro His Trp Asn Thr Arg Cys Pro Leu Ala Ser His Thr Asp Asp Ser 
65                  70                  75                  80  


Phe Thr Gly Ser Ser Ala Tyr Ile Pro Cys Arg Thr Trp Trp Ala Leu 
                85                  90                  95      


Phe Ser Thr Lys Pro Trp Cys Val Arg Val Trp His Cys Ser Arg Cys 
            100                 105                 110         


Leu Cys Gln His Leu Leu Ser Gly Gly Ser Gly Leu Gln Arg Gly Leu 
        115                 120                 125             


Phe His Leu Leu Val Gln Lys Ser Lys Lys Ser Ser Thr Phe Lys Phe 
    130                 135                 140                 


Tyr Arg Arg His Lys Met Pro Ala Pro Ala Gln Arg Lys Leu Leu Pro 
145                 150                 155                 160 


Arg Arg His Leu Ser Glu Lys Ser His His Ile Ser Ile Pro Ser Pro 
                165                 170                 175     


Asp Ile Ser His Lys Gly Leu Arg Ser Lys Arg Thr Gln Pro Ser Asp 
            180                 185                 190         


Pro Glu Thr Trp Glu Ser Leu Pro Arg Leu Asp Ser Gln Arg His Gly 
        195                 200                 205             


Gly Pro Glu Phe Ser Phe Asp Leu Leu Pro Glu Ala Arg Ala Ile Arg 
    210                 215                 220                 


Val Thr Ile Ser Ser Gly Pro Glu Val Ser Val Arg Leu Cys His Gln 
225                 230                 235                 240 


Trp Ala Leu Glu Cys Glu Glu Leu Ser Ser Pro Tyr Asp Val Gln Lys 
                245                 250                 255     


Ile Val Ser Gly Gly His Thr Val Glu Leu Pro Tyr Glu Phe Leu Leu 
            260                 265                 270         


Pro Cys Leu Cys Ile Glu Ala Ser Tyr Leu Gln Glu Asp Thr Val Arg 
        275                 280                 285             


Arg Lys Lys Cys Pro Phe Gln Ser Trp Pro Glu Ala Tyr Gly Ser Asp 
    290                 295                 300                 


Phe Trp Lys Ser Val His Phe Thr Asp Tyr Ser Gln His Thr Gln Met 
305                 310                 315                 320 


Val Met Ala Leu Thr Leu Arg Cys Pro Leu Lys Leu Glu Ala Ala Leu 
                325                 330                 335     


Cys Gln Arg His Asp Trp His Thr Leu Cys Lys Asp Leu Pro Asn Ala 
            340                 345                 350         


Thr Ala Arg Glu Ser Asp Gly Trp Tyr Val Leu Glu Lys Val Asp Leu 
        355                 360                 365             


His Pro Gln Leu Cys Phe Lys Phe Ser Phe Gly Asn Ser Ser His Val 
    370                 375                 380                 


Glu Cys Pro His Gln Thr Gly Ser Leu Thr Ser Trp Asn Val Ser Met 
385                 390                 395                 400 


Asp Thr Gln Ala Gln Gln Leu Ile Leu His Phe Ser Ser Arg Met His 
                405                 410                 415     


Ala Thr Phe Ser Ala Ala Trp Ser Leu Pro Gly Leu Gly Gln Asp Thr 
            420                 425                 430         


Leu Val Pro Pro Val Tyr Thr Val Ser Gln Ala Arg Gly Ser Ser Pro 
        435                 440                 445             


Val Ser Leu Asp Leu Ile Ile Pro Phe Leu Arg Pro Gly Cys Cys Val 
    450                 455                 460                 


Leu Val Trp Arg Ser Asp Val Gln Phe Ala Trp Lys His Leu Leu Cys 
465                 470                 475                 480 


Pro Asp Val Ser Tyr Arg His Leu Gly Leu Leu Ile Leu Ala Leu Leu 
                485                 490                 495     


Ala Leu Leu Thr Leu Leu Gly Val Val Leu Ala Leu Thr Cys Arg Arg 
            500                 505                 510         


Pro Gln Ser Gly Pro Gly Pro Ala Arg Pro Val Leu Leu Leu His Ala 
        515                 520                 525             


Ala Asp Ser Glu Ala Gln Arg Arg Leu Val Gly Ala Leu Ala Glu Leu 
    530                 535                 540                 


Leu Arg Ala Ala Leu Gly Gly Gly Arg Asp Val Ile Val Asp Leu Trp 
545                 550                 555                 560 


Glu Gly Arg His Val Ala Arg Val Gly Pro Leu Pro Trp Leu Trp Ala 
                565                 570                 575     


Ala Arg Thr Arg Val Ala Arg Glu Gln Gly Thr Val Leu Leu Leu Trp 
            580                 585                 590         


Ser Gly Ala Asp Leu Arg Pro Val Ser Gly Pro Asp Pro Arg Ala Ala 
        595                 600                 605             


Pro Leu Leu Ala Leu Leu His Ala Ala Pro Arg Pro Leu Leu Leu Leu 
    610                 615                 620                 


Ala Tyr Phe Ser Arg Leu Cys Ala Lys Gly Asp Ile Pro Pro Pro Leu 
625                 630                 635                 640 


Arg Ala Leu Pro Arg Tyr Arg Leu Leu Arg Asp Leu Pro Arg Leu Leu 
                645                 650                 655     


Arg Ala Leu Asp Ala Arg Pro Phe Ala Glu Ala Thr Ser Trp Gly Arg 
            660                 665                 670         


Leu Gly Ala Arg Gln Arg Arg Gln Ser Arg Leu Glu Leu Cys Ser Arg 
        675                 680                 685             


Leu Glu Arg Glu Ala Ala Arg Leu Ala Asp Leu Gly 
    690                 695                 700 


<210>  6931
<211>  194
<212>  PRT
<213>  Homo Sapiens

<400>  6931

Met Thr Met Arg His Asn Trp Thr Pro Asp Leu Ser Pro Leu Trp Val 
1               5                   10                  15      


Leu Leu Leu Cys Ala His Val Val Thr Leu Leu Val Arg Ala Thr Pro 
            20                  25                  30          


Val Ser Gln Thr Thr Thr Ala Ala Thr Ala Ser Val Arg Ser Thr Lys 
        35                  40                  45              


Asp Pro Cys Pro Ser Gln Pro Pro Val Phe Pro Ala Ala Lys Gln Cys 
    50                  55                  60                  


Pro Ala Leu Glu Val Thr Trp Pro Glu Val Glu Val Pro Leu Asn Gly 
65                  70                  75                  80  


Thr Leu Ser Leu Ser Cys Val Ala Cys Ser Arg Phe Pro Asn Phe Ser 
                85                  90                  95      


Ile Leu Tyr Trp Leu Gly Asn Gly Ser Phe Ile Glu His Leu Pro Gly 
            100                 105                 110         


Arg Leu Trp Glu Gly Ser Thr Ser Arg Glu Arg Gly Ser Thr Gly Thr 
        115                 120                 125             


Gln Leu Cys Lys Ala Leu Val Leu Glu Gln Leu Thr Pro Ala Leu His 
    130                 135                 140                 


Ser Thr Asn Phe Ser Cys Val Leu Val Asp Pro Glu Gln Val Val Gln 
145                 150                 155                 160 


Arg His Val Val Leu Ala Gln Leu Trp Ala Gly Leu Arg Ala Thr Leu 
                165                 170                 175     


Pro Pro Thr Gln Glu Ala Leu Pro Ser Ser His Ser Ser Pro Gln Gln 
            180                 185                 190         


Gln Gly 
        


<210>  6932
<211>  194
<212>  PRT
<213>  Homo Sapiens

<400>  6932

Met Thr Met Arg His Asn Trp Thr Pro Asp Leu Ser Pro Leu Trp Val 
1               5                   10                  15      


Leu Leu Leu Cys Ala His Val Val Thr Leu Leu Val Arg Ala Thr Pro 
            20                  25                  30          


Val Ser Gln Thr Thr Thr Ala Ala Thr Ala Ser Val Arg Ser Thr Lys 
        35                  40                  45              


Asp Pro Cys Pro Ser Gln Pro Pro Val Phe Pro Ala Ala Lys Gln Cys 
    50                  55                  60                  


Pro Ala Leu Glu Val Thr Trp Pro Glu Val Glu Val Pro Leu Asn Gly 
65                  70                  75                  80  


Thr Leu Ser Leu Ser Cys Val Ala Cys Ser Arg Phe Pro Asn Phe Ser 
                85                  90                  95      


Ile Leu Tyr Trp Leu Gly Asn Gly Ser Phe Ile Glu His Leu Pro Gly 
            100                 105                 110         


Arg Leu Trp Glu Gly Ser Thr Ser Arg Glu Arg Gly Ser Thr Gly Thr 
        115                 120                 125             


Gln Leu Cys Lys Ala Leu Val Leu Glu Gln Leu Thr Pro Ala Leu His 
    130                 135                 140                 


Ser Thr Asn Phe Ser Cys Val Leu Val Asp Pro Glu Gln Val Val Gln 
145                 150                 155                 160 


Arg His Val Val Leu Ala Gln Leu Trp Ala Gly Leu Arg Ala Thr Leu 
                165                 170                 175     


Pro Pro Thr Gln Glu Ala Leu Pro Ser Ser His Ser Ser Pro Gln Gln 
            180                 185                 190         


Gln Gly 
        


<210>  6933
<211>  194
<212>  PRT
<213>  Homo Sapiens

<400>  6933

Met Thr Met Arg His Asn Trp Thr Pro Asp Leu Ser Pro Leu Trp Val 
1               5                   10                  15      


Leu Leu Leu Cys Ala His Val Val Thr Leu Leu Val Arg Ala Thr Pro 
            20                  25                  30          


Val Ser Gln Thr Thr Thr Ala Ala Thr Ala Ser Val Arg Ser Thr Lys 
        35                  40                  45              


Asp Pro Cys Pro Ser Gln Pro Pro Val Phe Pro Ala Ala Lys Gln Cys 
    50                  55                  60                  


Pro Ala Leu Glu Val Thr Trp Pro Glu Val Glu Val Pro Leu Asn Gly 
65                  70                  75                  80  


Thr Leu Ser Leu Ser Cys Val Ala Cys Ser Arg Phe Pro Asn Phe Ser 
                85                  90                  95      


Ile Leu Tyr Trp Leu Gly Asn Gly Ser Phe Ile Glu His Leu Pro Gly 
            100                 105                 110         


Arg Leu Trp Glu Gly Ser Thr Ser Arg Glu Arg Gly Ser Thr Gly Thr 
        115                 120                 125             


Gln Leu Cys Lys Ala Leu Val Leu Glu Gln Leu Thr Pro Ala Leu His 
    130                 135                 140                 


Ser Thr Asn Phe Ser Cys Val Leu Val Asp Pro Glu Gln Val Val Gln 
145                 150                 155                 160 


Arg His Val Val Leu Ala Gln Leu Trp Ala Gly Leu Arg Ala Thr Leu 
                165                 170                 175     


Pro Pro Thr Gln Glu Ala Leu Pro Ser Ser His Ser Ser Pro Gln Gln 
            180                 185                 190         


Gln Gly 
        


<210>  6934
<211>  194
<212>  PRT
<213>  Homo Sapiens

<400>  6934

Met Thr Met Arg His Asn Trp Thr Pro Asp Leu Ser Pro Leu Trp Val 
1               5                   10                  15      


Leu Leu Leu Cys Ala His Val Val Thr Leu Leu Val Arg Ala Thr Pro 
            20                  25                  30          


Val Ser Gln Thr Thr Thr Ala Ala Thr Ala Ser Val Arg Ser Thr Lys 
        35                  40                  45              


Asp Pro Cys Pro Ser Gln Pro Pro Val Phe Pro Ala Ala Lys Gln Cys 
    50                  55                  60                  


Pro Ala Leu Glu Val Thr Trp Pro Glu Val Glu Val Pro Leu Asn Gly 
65                  70                  75                  80  


Thr Leu Ser Leu Ser Cys Val Ala Cys Ser Arg Phe Pro Asn Phe Ser 
                85                  90                  95      


Ile Leu Tyr Trp Leu Gly Asn Gly Ser Phe Ile Glu His Leu Pro Gly 
            100                 105                 110         


Arg Leu Trp Glu Gly Ser Thr Ser Arg Glu Arg Gly Ser Thr Gly Thr 
        115                 120                 125             


Gln Leu Cys Lys Ala Leu Val Leu Glu Gln Leu Thr Pro Ala Leu His 
    130                 135                 140                 


Ser Thr Asn Phe Ser Cys Val Leu Val Asp Pro Glu Gln Val Val Gln 
145                 150                 155                 160 


Arg His Val Val Leu Ala Gln Leu Trp Ala Gly Leu Arg Ala Thr Leu 
                165                 170                 175     


Pro Pro Thr Gln Glu Ala Leu Pro Ser Ser His Ser Ser Pro Gln Gln 
            180                 185                 190         


Gln Gly 
        


<210>  6935
<211>  194
<212>  PRT
<213>  Homo Sapiens

<400>  6935

Met Thr Met Arg His Asn Trp Thr Pro Asp Leu Ser Pro Leu Trp Val 
1               5                   10                  15      


Leu Leu Leu Cys Ala His Val Val Thr Leu Leu Val Arg Ala Thr Pro 
            20                  25                  30          


Val Ser Gln Thr Thr Thr Ala Ala Thr Ala Ser Val Arg Ser Thr Lys 
        35                  40                  45              


Asp Pro Cys Pro Ser Gln Pro Pro Val Phe Pro Ala Ala Lys Gln Cys 
    50                  55                  60                  


Pro Ala Leu Glu Val Thr Trp Pro Glu Val Glu Val Pro Leu Asn Gly 
65                  70                  75                  80  


Thr Leu Ser Leu Ser Cys Val Ala Cys Ser Arg Phe Pro Asn Phe Ser 
                85                  90                  95      


Ile Leu Tyr Trp Leu Gly Asn Gly Ser Phe Ile Glu His Leu Pro Gly 
            100                 105                 110         


Arg Leu Trp Glu Gly Ser Thr Ser Arg Glu Arg Gly Ser Thr Gly Thr 
        115                 120                 125             


Gln Leu Cys Lys Ala Leu Val Leu Glu Gln Leu Thr Pro Ala Leu His 
    130                 135                 140                 


Ser Thr Asn Phe Ser Cys Val Leu Val Asp Pro Glu Gln Val Val Gln 
145                 150                 155                 160 


Arg His Val Val Leu Ala Gln Leu Trp Ala Gly Leu Arg Ala Thr Leu 
                165                 170                 175     


Pro Pro Thr Gln Glu Ala Leu Pro Ser Ser His Ser Ser Pro Gln Gln 
            180                 185                 190         


Gln Gly 
        


<210>  6936
<211>  194
<212>  PRT
<213>  Homo Sapiens

<400>  6936

Met Thr Met Arg His Asn Trp Thr Pro Asp Leu Ser Pro Leu Trp Val 
1               5                   10                  15      


Leu Leu Leu Cys Ala His Val Val Thr Leu Leu Val Arg Ala Thr Pro 
            20                  25                  30          


Val Ser Gln Thr Thr Thr Ala Ala Thr Ala Ser Val Arg Ser Thr Lys 
        35                  40                  45              


Asp Pro Cys Pro Ser Gln Pro Pro Val Phe Pro Ala Ala Lys Gln Cys 
    50                  55                  60                  


Pro Ala Leu Glu Val Thr Trp Pro Glu Val Glu Val Pro Leu Asn Gly 
65                  70                  75                  80  


Thr Leu Ser Leu Ser Cys Val Ala Cys Ser Arg Phe Pro Asn Phe Ser 
                85                  90                  95      


Ile Leu Tyr Trp Leu Gly Asn Gly Ser Phe Ile Glu His Leu Pro Gly 
            100                 105                 110         


Arg Leu Trp Glu Gly Ser Thr Ser Arg Glu Arg Gly Ser Thr Gly Thr 
        115                 120                 125             


Gln Leu Cys Lys Ala Leu Val Leu Glu Gln Leu Thr Pro Ala Leu His 
    130                 135                 140                 


Ser Thr Asn Phe Ser Cys Val Leu Val Asp Pro Glu Gln Val Val Gln 
145                 150                 155                 160 


Arg His Val Val Leu Ala Gln Leu Trp Ala Gly Leu Arg Ala Thr Leu 
                165                 170                 175     


Pro Pro Thr Gln Glu Ala Leu Pro Ser Ser His Ser Ser Pro Gln Gln 
            180                 185                 190         


Gln Gly 
        


<210>  6937
<211>  199
<212>  PRT
<213>  Homo Sapiens

<400>  6937

Met Thr Met Arg His Asn Trp Thr Pro Asp Leu Ser Pro Leu Trp Val 
1               5                   10                  15      


Leu Leu Leu Cys Ala His Val Val Thr Leu Leu Val Arg Ala Thr Pro 
            20                  25                  30          


Val Ser Gln Thr Thr Thr Ala Ala Thr Ala Ser Val Arg Ser Thr Lys 
        35                  40                  45              


Asp Pro Cys Pro Ser Gln Pro Pro Val Phe Pro Ala Ala Lys Gln Cys 
    50                  55                  60                  


Pro Ala Leu Glu Val Thr Trp Pro Glu Val Glu Val Pro Leu Asn Gly 
65                  70                  75                  80  


Thr Leu Ser Leu Ser Cys Val Ala Cys Ser Arg Phe Pro Asn Phe Ser 
                85                  90                  95      


Ile Leu Tyr Trp Leu Gly Asn Gly Ser Phe Ile Glu His Leu Pro Gly 
            100                 105                 110         


Arg Leu Trp Glu Gly Ser Thr Ser Arg Glu Arg Gly Ser Thr Gly Thr 
        115                 120                 125             


Gln Leu Cys Lys Ala Leu Val Leu Glu Gln Leu Thr Pro Ala Leu His 
    130                 135                 140                 


Ser Thr Asn Phe Ser Cys Val Leu Val Asp Pro Glu Gln Val Val Gln 
145                 150                 155                 160 


Arg His Val Val Leu Ala Gln Leu Trp Val Arg Ser Pro Arg Arg Gly 
                165                 170                 175     


Leu Gln Glu Gln Glu Glu Leu Cys Phe His Met Trp Gly Gly Lys Gly 
            180                 185                 190         


Gly Leu Cys Gln Ser Ser Leu 
        195                 


<210>  6938
<211>  199
<212>  PRT
<213>  Homo Sapiens

<400>  6938

Met Thr Met Arg His Asn Trp Thr Pro Asp Leu Ser Pro Leu Trp Val 
1               5                   10                  15      


Leu Leu Leu Cys Ala His Val Val Thr Leu Leu Val Arg Ala Thr Pro 
            20                  25                  30          


Val Ser Gln Thr Thr Thr Ala Ala Thr Ala Ser Val Arg Ser Thr Lys 
        35                  40                  45              


Asp Pro Cys Pro Ser Gln Pro Pro Val Phe Pro Ala Ala Lys Gln Cys 
    50                  55                  60                  


Pro Ala Leu Glu Val Thr Trp Pro Glu Val Glu Val Pro Leu Asn Gly 
65                  70                  75                  80  


Thr Leu Ser Leu Ser Cys Val Ala Cys Ser Arg Phe Pro Asn Phe Ser 
                85                  90                  95      


Ile Leu Tyr Trp Leu Gly Asn Gly Ser Phe Ile Glu His Leu Pro Gly 
            100                 105                 110         


Arg Leu Trp Glu Gly Ser Thr Ser Arg Glu Arg Gly Ser Thr Gly Thr 
        115                 120                 125             


Gln Leu Cys Lys Ala Leu Val Leu Glu Gln Leu Thr Pro Ala Leu His 
    130                 135                 140                 


Ser Thr Asn Phe Ser Cys Val Leu Val Asp Pro Glu Gln Val Val Gln 
145                 150                 155                 160 


Arg His Val Val Leu Ala Gln Leu Trp Val Arg Ser Pro Arg Arg Gly 
                165                 170                 175     


Leu Gln Glu Gln Glu Glu Leu Cys Phe His Met Trp Gly Gly Lys Gly 
            180                 185                 190         


Gly Leu Cys Gln Ser Ser Leu 
        195                 


<210>  6939
<211>  163
<212>  PRT
<213>  Homo Sapiens

<400>  6939

Met Thr Met Arg His Asn Trp Thr Pro Asp Leu Ser Pro Leu Trp Val 
1               5                   10                  15      


Leu Leu Leu Cys Ala His Val Val Thr Leu Leu Val Arg Ala Thr Pro 
            20                  25                  30          


Val Ser Gln Thr Thr Thr Ala Ala Thr Ala Ser Val Arg Ser Thr Lys 
        35                  40                  45              


Asp Pro Cys Pro Ser Gln Pro Pro Val Phe Pro Ala Ala Lys Gln Cys 
    50                  55                  60                  


Pro Ala Leu Glu Val Thr Trp Pro Glu Val Glu Val Pro Leu Asn Gly 
65                  70                  75                  80  


Thr Leu Ser Leu Ser Cys Val Ala Cys Ser Arg Phe Pro Asn Phe Ser 
                85                  90                  95      


Ile Leu Tyr Trp Leu Gly Asn Gly Ser Phe Ile Glu His Leu Pro Gly 
            100                 105                 110         


Arg Leu Trp Glu Gly Ser Thr Ser Arg Glu Arg Gly Ser Thr Gly Trp 
        115                 120                 125             


Ala Glu Gly Asn Leu Ala Pro His Pro Arg Ser Pro Ala Leu Gln Pro 
    130                 135                 140                 


Gln Gln Ser Thr Ala Ala Gly Leu Arg Leu Ser Thr Gly Pro Ala Ala 
145                 150                 155                 160 


Ala Gln Pro 
            


<210>  6940
<211>  163
<212>  PRT
<213>  Homo Sapiens

<400>  6940

Met Thr Met Arg His Asn Trp Thr Pro Asp Leu Ser Pro Leu Trp Val 
1               5                   10                  15      


Leu Leu Leu Cys Ala His Val Val Thr Leu Leu Val Arg Ala Thr Pro 
            20                  25                  30          


Val Ser Gln Thr Thr Thr Ala Ala Thr Ala Ser Val Arg Ser Thr Lys 
        35                  40                  45              


Asp Pro Cys Pro Ser Gln Pro Pro Val Phe Pro Ala Ala Lys Gln Cys 
    50                  55                  60                  


Pro Ala Leu Glu Val Thr Trp Pro Glu Val Glu Val Pro Leu Asn Gly 
65                  70                  75                  80  


Thr Leu Ser Leu Ser Cys Val Ala Cys Ser Arg Phe Pro Asn Phe Ser 
                85                  90                  95      


Ile Leu Tyr Trp Leu Gly Asn Gly Ser Phe Ile Glu His Leu Pro Gly 
            100                 105                 110         


Arg Leu Trp Glu Gly Ser Thr Ser Arg Glu Arg Gly Ser Thr Gly Trp 
        115                 120                 125             


Ala Glu Gly Asn Leu Ala Pro His Pro Arg Ser Pro Ala Leu Gln Pro 
    130                 135                 140                 


Gln Gln Ser Thr Ala Ala Gly Leu Arg Leu Ser Thr Gly Pro Ala Ala 
145                 150                 155                 160 


Ala Gln Pro 
            


<210>  6941
<211>  115
<212>  PRT
<213>  Homo Sapiens

<400>  6941

Met Thr Met Arg His Asn Trp Thr Pro Asp Leu Ser Pro Leu Trp Val 
1               5                   10                  15      


Leu Leu Leu Cys Ala His Val Val Thr Leu Leu Val Arg Ala Thr Pro 
            20                  25                  30          


Val Ser Gln Thr Thr Thr Ala Ala Thr Ala Ser Val Arg Ser Thr Lys 
        35                  40                  45              


Asp Pro Cys Pro Ser Gln Pro Pro Val Phe Pro Ala Ala Lys Gln Cys 
    50                  55                  60                  


Pro Ala Leu Glu Val Thr Trp Pro Glu Val Glu Val Pro Leu Ser Trp 
65                  70                  75                  80  


Ala Glu Gly Asn Leu Ala Pro His Pro Arg Ser Pro Ala Leu Gln Pro 
                85                  90                  95      


Gln Gln Ser Thr Ala Ala Gly Leu Arg Leu Ser Thr Gly Pro Ala Ala 
            100                 105                 110         


Ala Gln Pro 
        115 


<210>  6942
<211>  170
<212>  PRT
<213>  Homo Sapiens

<400>  6942

Met Asn Cys Arg Glu Leu Pro Leu Thr Leu Trp Val Leu Ile Ser Val 
1               5                   10                  15      


Ser Thr Ala Glu Ser Cys Thr Ser Arg Pro His Ile Thr Val Val Glu 
            20                  25                  30          


Gly Glu Pro Phe Tyr Leu Lys His Cys Ser Cys Ser Leu Ala His Glu 
        35                  40                  45              


Ile Glu Thr Thr Thr Lys Ser Trp Tyr Lys Ser Ser Gly Ser Gln Glu 
    50                  55                  60                  


His Val Glu Leu Asn Pro Arg Ser Ser Ser Arg Ile Ala Leu His Asp 
65                  70                  75                  80  


Cys Val Leu Glu Phe Trp Pro Val Glu Leu Asn Asp Thr Gly Ser Tyr 
                85                  90                  95      


Phe Phe Gln Met Lys Asn Tyr Thr Gln Lys Trp Lys Leu Asn Val Ile 
            100                 105                 110         


Arg Arg Asn Lys His Ser Cys Phe Thr Glu Arg Gln Val Thr Ser Lys 
        115                 120                 125             


Ile Val Glu Val Lys Lys Phe Phe Gln Ile Thr Cys Glu Asn Ser Tyr 
    130                 135                 140                 


Tyr Gln Thr Leu Val Asn Ser Thr Ser Leu Tyr Lys Ile Gly Pro Pro 
145                 150                 155                 160 


Ile Cys Arg Lys Thr Ser Ser Gly Leu His 
                165                 170 


<210>  6943
<211>  541
<212>  PRT
<213>  Homo Sapiens

<400>  6943

Met Asn Cys Arg Glu Leu Pro Leu Thr Leu Trp Val Leu Ile Ser Val 
1               5                   10                  15      


Ser Thr Ala Glu Ser Cys Thr Ser Arg Pro His Ile Thr Val Val Glu 
            20                  25                  30          


Gly Glu Pro Phe Tyr Leu Lys His Cys Ser Cys Ser Leu Ala His Glu 
        35                  40                  45              


Ile Glu Thr Thr Thr Lys Ser Trp Tyr Lys Ser Ser Gly Ser Gln Glu 
    50                  55                  60                  


His Val Glu Leu Asn Pro Arg Ser Ser Ser Arg Ile Ala Leu His Asp 
65                  70                  75                  80  


Cys Val Leu Glu Phe Trp Pro Val Glu Leu Asn Asp Thr Gly Ser Tyr 
                85                  90                  95      


Phe Phe Gln Met Lys Asn Tyr Thr Gln Lys Trp Lys Leu Asn Val Ile 
            100                 105                 110         


Arg Arg Asn Lys His Ser Cys Phe Thr Glu Arg Gln Val Thr Ser Lys 
        115                 120                 125             


Ile Val Glu Val Lys Lys Phe Phe Gln Ile Thr Cys Glu Asn Ser Tyr 
    130                 135                 140                 


Tyr Gln Thr Leu Val Asn Ser Thr Ser Leu Tyr Lys Asn Cys Lys Lys 
145                 150                 155                 160 


Leu Leu Leu Glu Asn Asn Lys Asn Pro Thr Ile Lys Lys Asn Ala Glu 
                165                 170                 175     


Phe Glu Asp Gln Gly Tyr Tyr Ser Cys Val His Phe Leu His His Asn 
            180                 185                 190         


Gly Lys Leu Phe Asn Ile Thr Lys Thr Phe Asn Ile Thr Ile Val Glu 
        195                 200                 205             


Asp Arg Ser Asn Ile Val Pro Val Leu Leu Gly Pro Lys Leu Asn His 
    210                 215                 220                 


Val Ala Val Glu Leu Gly Lys Asn Val Arg Leu Asn Cys Ser Ala Leu 
225                 230                 235                 240 


Leu Asn Glu Glu Asp Val Ile Tyr Trp Met Phe Gly Glu Glu Asn Gly 
                245                 250                 255     


Ser Asp Pro Asn Ile His Glu Glu Lys Glu Met Arg Ile Met Thr Pro 
            260                 265                 270         


Glu Gly Lys Trp His Ala Ser Lys Val Leu Arg Ile Glu Asn Ile Gly 
        275                 280                 285             


Glu Ser Asn Leu Asn Val Leu Tyr Asn Cys Thr Val Ala Ser Thr Gly 
    290                 295                 300                 


Gly Thr Asp Thr Lys Ser Phe Ile Leu Val Arg Lys Ala Asp Met Ala 
305                 310                 315                 320 


Asp Ile Pro Gly His Val Phe Thr Arg Gly Met Ile Ile Ala Val Leu 
                325                 330                 335     


Ile Leu Val Ala Val Val Cys Leu Val Thr Val Cys Val Ile Tyr Arg 
            340                 345                 350         


Val Asp Leu Val Leu Phe Tyr Arg His Leu Thr Arg Arg Asp Glu Thr 
        355                 360                 365             


Leu Thr Asp Gly Lys Thr Tyr Asp Ala Phe Val Ser Tyr Leu Lys Glu 
    370                 375                 380                 


Cys Arg Pro Glu Asn Gly Glu Glu His Thr Phe Ala Val Glu Ile Leu 
385                 390                 395                 400 


Pro Arg Val Leu Glu Lys His Phe Gly Tyr Lys Leu Cys Ile Phe Glu 
                405                 410                 415     


Arg Asp Val Val Pro Gly Gly Ala Val Val Asp Glu Ile His Ser Leu 
            420                 425                 430         


Ile Glu Lys Ser Arg Arg Leu Ile Ile Val Leu Ser Lys Ser Tyr Met 
        435                 440                 445             


Ser Asn Glu Val Arg Tyr Glu Leu Glu Ser Gly Leu His Glu Ala Leu 
    450                 455                 460                 


Val Glu Arg Lys Ile Lys Ile Ile Leu Ile Glu Phe Thr Pro Val Thr 
465                 470                 475                 480 


Asp Phe Thr Phe Leu Pro Gln Ser Leu Lys Leu Leu Lys Ser His Arg 
                485                 490                 495     


Val Leu Lys Trp Lys Ala Asp Lys Ser Leu Ser Tyr Asn Ser Arg Phe 
            500                 505                 510         


Trp Lys Asn Leu Leu Tyr Leu Met Pro Ala Lys Thr Val Lys Pro Gly 
        515                 520                 525             


Arg Asp Glu Pro Glu Val Leu Pro Val Leu Ser Glu Ser 
    530                 535                 540     


<210>  6944
<211>  541
<212>  PRT
<213>  Homo Sapiens

<400>  6944

Met Asn Cys Arg Glu Leu Pro Leu Thr Leu Trp Val Leu Ile Ser Val 
1               5                   10                  15      


Ser Thr Ala Glu Ser Cys Thr Ser Arg Pro His Ile Thr Val Val Glu 
            20                  25                  30          


Gly Glu Pro Phe Tyr Leu Lys His Cys Ser Cys Ser Leu Ala His Glu 
        35                  40                  45              


Ile Glu Thr Thr Thr Lys Ser Trp Tyr Lys Ser Ser Gly Ser Gln Glu 
    50                  55                  60                  


His Val Glu Leu Asn Pro Arg Ser Ser Ser Arg Ile Ala Leu His Asp 
65                  70                  75                  80  


Cys Val Leu Glu Phe Trp Pro Val Glu Leu Asn Asp Thr Gly Ser Tyr 
                85                  90                  95      


Phe Phe Gln Met Lys Asn Tyr Thr Gln Lys Trp Lys Leu Asn Val Ile 
            100                 105                 110         


Arg Arg Asn Lys His Ser Cys Phe Thr Glu Arg Gln Val Thr Ser Lys 
        115                 120                 125             


Ile Val Glu Val Lys Lys Phe Phe Gln Ile Thr Cys Glu Asn Ser Tyr 
    130                 135                 140                 


Tyr Gln Thr Leu Val Asn Ser Thr Ser Leu Tyr Lys Asn Cys Lys Lys 
145                 150                 155                 160 


Leu Leu Leu Glu Asn Asn Lys Asn Pro Thr Ile Lys Lys Asn Ala Glu 
                165                 170                 175     


Phe Glu Asp Gln Gly Tyr Tyr Ser Cys Val His Phe Leu His His Asn 
            180                 185                 190         


Gly Lys Leu Phe Asn Ile Thr Lys Thr Phe Asn Ile Thr Ile Val Glu 
        195                 200                 205             


Asp Arg Ser Asn Ile Val Pro Val Leu Leu Gly Pro Lys Leu Asn His 
    210                 215                 220                 


Val Ala Val Glu Leu Gly Lys Asn Val Arg Leu Asn Cys Ser Ala Leu 
225                 230                 235                 240 


Leu Asn Glu Glu Asp Val Ile Tyr Trp Met Phe Gly Glu Glu Asn Gly 
                245                 250                 255     


Ser Asp Pro Asn Ile His Glu Glu Lys Glu Met Arg Ile Met Thr Pro 
            260                 265                 270         


Glu Gly Lys Trp His Ala Ser Lys Val Leu Arg Ile Glu Asn Ile Gly 
        275                 280                 285             


Glu Ser Asn Leu Asn Val Leu Tyr Asn Cys Thr Val Ala Ser Thr Gly 
    290                 295                 300                 


Gly Thr Asp Thr Lys Ser Phe Ile Leu Val Arg Lys Ala Asp Met Ala 
305                 310                 315                 320 


Asp Ile Pro Gly His Val Phe Thr Arg Gly Met Ile Ile Ala Val Leu 
                325                 330                 335     


Ile Leu Val Ala Val Val Cys Leu Val Thr Val Cys Val Ile Tyr Arg 
            340                 345                 350         


Val Asp Leu Val Leu Phe Tyr Arg His Leu Thr Arg Arg Asp Glu Thr 
        355                 360                 365             


Leu Thr Asp Gly Lys Thr Tyr Asp Ala Phe Val Ser Tyr Leu Lys Glu 
    370                 375                 380                 


Cys Arg Pro Glu Asn Gly Glu Glu His Thr Phe Ala Val Glu Ile Leu 
385                 390                 395                 400 


Pro Arg Val Leu Glu Lys His Phe Gly Tyr Lys Leu Cys Ile Phe Glu 
                405                 410                 415     


Arg Asp Val Val Pro Gly Gly Ala Val Val Asp Glu Ile His Ser Leu 
            420                 425                 430         


Ile Glu Lys Ser Arg Arg Leu Ile Ile Val Leu Ser Lys Ser Tyr Met 
        435                 440                 445             


Ser Asn Glu Val Arg Tyr Glu Leu Glu Ser Gly Leu His Glu Ala Leu 
    450                 455                 460                 


Val Glu Arg Lys Ile Lys Ile Ile Leu Ile Glu Phe Thr Pro Val Thr 
465                 470                 475                 480 


Asp Phe Thr Phe Leu Pro Gln Ser Leu Lys Leu Leu Lys Ser His Arg 
                485                 490                 495     


Val Leu Lys Trp Lys Ala Asp Lys Ser Leu Ser Tyr Asn Ser Arg Phe 
            500                 505                 510         


Trp Lys Asn Leu Leu Tyr Leu Met Pro Ala Lys Thr Val Lys Pro Gly 
        515                 520                 525             


Arg Asp Glu Pro Glu Val Leu Pro Val Leu Ser Glu Ser 
    530                 535                 540     


<210>  6945
<211>  541
<212>  PRT
<213>  Homo Sapiens

<400>  6945

Met Asn Cys Arg Glu Leu Pro Leu Thr Leu Trp Val Leu Ile Ser Val 
1               5                   10                  15      


Ser Thr Ala Glu Ser Cys Thr Ser Arg Pro His Ile Thr Val Val Glu 
            20                  25                  30          


Gly Glu Pro Phe Tyr Leu Lys His Cys Ser Cys Ser Leu Ala His Glu 
        35                  40                  45              


Ile Glu Thr Thr Thr Lys Ser Trp Tyr Lys Ser Ser Gly Ser Gln Glu 
    50                  55                  60                  


His Val Glu Leu Asn Pro Arg Ser Ser Ser Arg Ile Ala Leu His Asp 
65                  70                  75                  80  


Cys Val Leu Glu Phe Trp Pro Val Glu Leu Asn Asp Thr Gly Ser Tyr 
                85                  90                  95      


Phe Phe Gln Met Lys Asn Tyr Thr Gln Lys Trp Lys Leu Asn Val Ile 
            100                 105                 110         


Arg Arg Asn Lys His Ser Cys Phe Thr Glu Arg Gln Val Thr Ser Lys 
        115                 120                 125             


Ile Val Glu Val Lys Lys Phe Phe Gln Ile Thr Cys Glu Asn Ser Tyr 
    130                 135                 140                 


Tyr Gln Thr Leu Val Asn Ser Thr Ser Leu Tyr Lys Asn Cys Lys Lys 
145                 150                 155                 160 


Leu Leu Leu Glu Asn Asn Lys Asn Pro Thr Ile Lys Lys Asn Ala Glu 
                165                 170                 175     


Phe Glu Asp Gln Gly Tyr Tyr Ser Cys Val His Phe Leu His His Asn 
            180                 185                 190         


Gly Lys Leu Phe Asn Ile Thr Lys Thr Phe Asn Ile Thr Ile Val Glu 
        195                 200                 205             


Asp Arg Ser Asn Ile Val Pro Val Leu Leu Gly Pro Lys Leu Asn His 
    210                 215                 220                 


Val Ala Val Glu Leu Gly Lys Asn Val Arg Leu Asn Cys Ser Ala Leu 
225                 230                 235                 240 


Leu Asn Glu Glu Asp Val Ile Tyr Trp Met Phe Gly Glu Glu Asn Gly 
                245                 250                 255     


Ser Asp Pro Asn Ile His Glu Glu Lys Glu Met Arg Ile Met Thr Pro 
            260                 265                 270         


Glu Gly Lys Trp His Ala Ser Lys Val Leu Arg Ile Glu Asn Ile Gly 
        275                 280                 285             


Glu Ser Asn Leu Asn Val Leu Tyr Asn Cys Thr Val Ala Ser Thr Gly 
    290                 295                 300                 


Gly Thr Asp Thr Lys Ser Phe Ile Leu Val Arg Lys Ala Asp Met Ala 
305                 310                 315                 320 


Asp Ile Pro Gly His Val Phe Thr Arg Gly Met Ile Ile Ala Val Leu 
                325                 330                 335     


Ile Leu Val Ala Val Val Cys Leu Val Thr Val Cys Val Ile Tyr Arg 
            340                 345                 350         


Val Asp Leu Val Leu Phe Tyr Arg His Leu Thr Arg Arg Asp Glu Thr 
        355                 360                 365             


Leu Thr Asp Gly Lys Thr Tyr Asp Ala Phe Val Ser Tyr Leu Lys Glu 
    370                 375                 380                 


Cys Arg Pro Glu Asn Gly Glu Glu His Thr Phe Ala Val Glu Ile Leu 
385                 390                 395                 400 


Pro Arg Val Leu Glu Lys His Phe Gly Tyr Lys Leu Cys Ile Phe Glu 
                405                 410                 415     


Arg Asp Val Val Pro Gly Gly Ala Val Val Asp Glu Ile His Ser Leu 
            420                 425                 430         


Ile Glu Lys Ser Arg Arg Leu Ile Ile Val Leu Ser Lys Ser Tyr Met 
        435                 440                 445             


Ser Asn Glu Val Arg Tyr Glu Leu Glu Ser Gly Leu His Glu Ala Leu 
    450                 455                 460                 


Val Glu Arg Lys Ile Lys Ile Ile Leu Ile Glu Phe Thr Pro Val Thr 
465                 470                 475                 480 


Asp Phe Thr Phe Leu Pro Gln Ser Leu Lys Leu Leu Lys Ser His Arg 
                485                 490                 495     


Val Leu Lys Trp Lys Ala Asp Lys Ser Leu Ser Tyr Asn Ser Arg Phe 
            500                 505                 510         


Trp Lys Asn Leu Leu Tyr Leu Met Pro Ala Lys Thr Val Lys Pro Gly 
        515                 520                 525             


Arg Asp Glu Pro Glu Val Leu Pro Val Leu Ser Glu Ser 
    530                 535                 540     


<210>  6946
<211>  457
<212>  PRT
<213>  Homo Sapiens

<400>  6946

Met Ile Leu Glu Val Lys Pro Gln Thr Asn Ala Ser Cys Glu Tyr Ser 
1               5                   10                  15      


Ala Ser His Lys Gln Asp Leu Leu Leu Gly Ser Thr Gly Ser Ile Ser 
            20                  25                  30          


Cys Pro Ser Leu Ser Cys Gln Ser Asp Ala Gln Ser Pro Ala Val Thr 
        35                  40                  45              


Trp Tyr Lys Asn Gly Lys Leu Leu Ser Val Glu Arg Ser Asn Arg Ile 
    50                  55                  60                  


Val Val Asp Glu Val Tyr Asp Tyr His Gln Gly Thr Tyr Val Cys Asp 
65                  70                  75                  80  


Tyr Thr Gln Ser Asp Thr Val Ser Ser Trp Thr Val Arg Ala Val Val 
                85                  90                  95      


Gln Val Arg Thr Ile Val Gly Asp Thr Lys Leu Lys Pro Asp Ile Leu 
            100                 105                 110         


Asp Pro Val Glu Asp Thr Leu Glu Val Glu Leu Gly Lys Pro Leu Thr 
        115                 120                 125             


Ile Ser Cys Lys Ala Arg Phe Gly Phe Glu Arg Val Phe Asn Pro Val 
    130                 135                 140                 


Ile Lys Trp Tyr Ile Lys Asp Ser Asp Leu Glu Trp Glu Val Ser Val 
145                 150                 155                 160 


Pro Glu Ala Lys Ser Ile Lys Ser Thr Leu Lys Asp Glu Ile Ile Glu 
                165                 170                 175     


Arg Asn Ile Ile Leu Glu Lys Val Thr Gln Arg Asp Leu Arg Arg Lys 
            180                 185                 190         


Phe Val Cys Phe Val Gln Asn Ser Ile Gly Asn Thr Thr Gln Ser Val 
        195                 200                 205             


Gln Leu Lys Glu Lys Arg Gly Val Val Leu Leu Tyr Ile Leu Leu Gly 
    210                 215                 220                 


Thr Ile Gly Thr Leu Val Ala Val Leu Ala Ala Ser Ala Leu Leu Tyr 
225                 230                 235                 240 


Arg His Trp Ile Glu Ile Val Leu Leu Tyr Arg Thr Tyr Gln Ser Lys 
                245                 250                 255     


Asp Gln Thr Leu Gly Asp Lys Lys Asp Phe Asp Ala Phe Val Ser Tyr 
            260                 265                 270         


Ala Lys Trp Ser Ser Phe Pro Ser Glu Ala Thr Ser Ser Leu Ser Glu 
        275                 280                 285             


Glu His Leu Ala Leu Ser Leu Phe Pro Asp Val Leu Glu Asn Lys Tyr 
    290                 295                 300                 


Gly Tyr Ser Leu Cys Leu Leu Glu Arg Asp Val Ala Pro Gly Gly Val 
305                 310                 315                 320 


Tyr Ala Glu Asp Ile Val Ser Ile Ile Lys Arg Ser Arg Arg Gly Ile 
                325                 330                 335     


Phe Ile Leu Ser Pro Asn Tyr Val Asn Gly Pro Ser Ile Phe Glu Leu 
            340                 345                 350         


Gln Ala Ala Val Asn Leu Ala Leu Asp Asp Gln Thr Leu Lys Leu Ile 
        355                 360                 365             


Leu Ile Lys Phe Cys Tyr Phe Gln Glu Pro Glu Ser Leu Pro His Leu 
    370                 375                 380                 


Val Lys Lys Ala Leu Arg Val Leu Pro Thr Val Thr Trp Arg Gly Leu 
385                 390                 395                 400 


Lys Ser Val Pro Pro Asn Ser Arg Phe Trp Ala Lys Met Arg Tyr His 
                405                 410                 415     


Met Pro Val Lys Asn Ser Gln Gly Phe Thr Trp Asn Gln Leu Arg Ile 
            420                 425                 430         


Thr Ser Arg Ile Phe Gln Trp Lys Gly Leu Ser Arg Thr Glu Thr Thr 
        435                 440                 445             


Gly Arg Ser Ser Gln Pro Lys Glu Trp 
    450                 455         


<210>  6947
<211>  44
<212>  PRT
<213>  Homo Sapiens

<400>  6947

Met Leu Cys Leu Gly Trp Ile Phe Leu Trp Leu Val Ala Gly Glu Arg 
1               5                   10                  15      


Ile Lys Gly Phe Asn Ile Ser Gly Cys Ser Thr Lys Lys Leu Leu Trp 
            20                  25                  30          


Thr Tyr Ser Thr Arg Ser Glu Glu Glu Phe Val Leu 
        35                  40                  


<210>  6948
<211>  599
<212>  PRT
<213>  Homo Sapiens

<400>  6948

Met Leu Cys Leu Gly Trp Ile Phe Leu Trp Leu Val Ala Gly Glu Arg 
1               5                   10                  15      


Ile Lys Gly Phe Asn Ile Ser Gly Cys Ser Thr Lys Lys Leu Leu Trp 
            20                  25                  30          


Thr Tyr Ser Thr Arg Ser Glu Glu Glu Phe Val Leu Phe Cys Asp Leu 
        35                  40                  45              


Pro Glu Pro Gln Lys Ser His Phe Cys His Arg Asn Arg Leu Ser Pro 
    50                  55                  60                  


Lys Gln Val Pro Glu His Leu Pro Phe Met Gly Ser Asn Asp Leu Ser 
65                  70                  75                  80  


Asp Val Gln Trp Tyr Gln Gln Pro Ser Asn Gly Asp Pro Leu Glu Asp 
                85                  90                  95      


Ile Arg Lys Ser Tyr Pro His Ile Ile Gln Asp Lys Cys Thr Leu His 
            100                 105                 110         


Phe Leu Thr Pro Gly Val Asn Asn Ser Gly Ser Tyr Ile Cys Arg Pro 
        115                 120                 125             


Lys Met Ile Lys Ser Pro Tyr Asp Val Ala Cys Cys Val Lys Met Ile 
    130                 135                 140                 


Leu Glu Val Lys Pro Gln Thr Asn Ala Ser Cys Glu Tyr Ser Ala Ser 
145                 150                 155                 160 


His Lys Gln Asp Leu Leu Leu Gly Ser Thr Gly Ser Ile Ser Cys Pro 
                165                 170                 175     


Ser Leu Ser Cys Gln Ser Asp Ala Gln Ser Pro Ala Val Thr Trp Tyr 
            180                 185                 190         


Lys Asn Gly Lys Leu Leu Ser Val Glu Arg Ser Asn Arg Ile Val Val 
        195                 200                 205             


Asp Glu Val Tyr Asp Tyr His Gln Gly Thr Tyr Val Cys Asp Tyr Thr 
    210                 215                 220                 


Gln Ser Asp Thr Val Ser Ser Trp Thr Val Arg Ala Val Val Gln Val 
225                 230                 235                 240 


Arg Thr Ile Val Gly Asp Thr Lys Leu Lys Pro Asp Ile Leu Asp Pro 
                245                 250                 255     


Val Glu Asp Thr Leu Glu Val Glu Leu Gly Lys Pro Leu Thr Ile Ser 
            260                 265                 270         


Cys Lys Ala Arg Phe Gly Phe Glu Arg Val Phe Asn Pro Val Ile Lys 
        275                 280                 285             


Trp Tyr Ile Lys Asp Ser Asp Leu Glu Trp Glu Val Ser Val Pro Glu 
    290                 295                 300                 


Ala Lys Ser Ile Lys Ser Thr Leu Lys Asp Glu Ile Ile Glu Arg Asn 
305                 310                 315                 320 


Ile Ile Leu Glu Lys Val Thr Gln Arg Asp Leu Arg Arg Lys Phe Val 
                325                 330                 335     


Cys Phe Val Gln Asn Ser Ile Gly Asn Thr Thr Gln Ser Val Gln Leu 
            340                 345                 350         


Lys Glu Lys Arg Gly Val Val Leu Leu Tyr Ile Leu Leu Gly Thr Ile 
        355                 360                 365             


Gly Thr Leu Val Ala Val Leu Ala Ala Ser Ala Leu Leu Tyr Arg His 
    370                 375                 380                 


Trp Ile Glu Ile Val Leu Leu Tyr Arg Thr Tyr Gln Ser Lys Asp Gln 
385                 390                 395                 400 


Thr Leu Gly Asp Lys Lys Asp Phe Asp Ala Phe Val Ser Tyr Ala Lys 
                405                 410                 415     


Trp Ser Ser Phe Pro Ser Glu Ala Thr Ser Ser Leu Ser Glu Glu His 
            420                 425                 430         


Leu Ala Leu Ser Leu Phe Pro Asp Val Leu Glu Asn Lys Tyr Gly Tyr 
        435                 440                 445             


Ser Leu Cys Leu Leu Glu Arg Asp Val Ala Pro Gly Gly Val Tyr Ala 
    450                 455                 460                 


Glu Asp Ile Val Ser Ile Ile Lys Arg Ser Arg Arg Gly Ile Phe Ile 
465                 470                 475                 480 


Leu Ser Pro Asn Tyr Val Asn Gly Pro Ser Ile Phe Glu Leu Gln Ala 
                485                 490                 495     


Ala Val Asn Leu Ala Leu Asp Asp Gln Thr Leu Lys Leu Ile Leu Ile 
            500                 505                 510         


Lys Phe Cys Tyr Phe Gln Glu Pro Glu Ser Leu Pro His Leu Val Lys 
        515                 520                 525             


Lys Ala Leu Arg Val Leu Pro Thr Val Thr Trp Arg Gly Leu Lys Ser 
    530                 535                 540                 


Val Pro Pro Asn Ser Arg Phe Trp Ala Lys Met Arg Tyr His Met Pro 
545                 550                 555                 560 


Val Lys Asn Ser Gln Gly Phe Thr Trp Asn Gln Leu Arg Ile Thr Ser 
                565                 570                 575     


Arg Ile Phe Gln Trp Lys Gly Leu Ser Arg Thr Glu Thr Thr Gly Arg 
            580                 585                 590         


Ser Ser Gln Pro Lys Glu Trp 
        595                 


<210>  6949
<211>  215
<212>  PRT
<213>  Homo Sapiens

<400>  6949

Met Cys Thr Glu Gly Ala Phe Pro His Arg Ser Ala Cys Ser Leu Pro 
1               5                   10                  15      


Leu Thr His Val His Thr His Ile His Val Cys Val Pro Val Leu Trp 
            20                  25                  30          


Gly Ser Val Pro Arg Gly Met Lys Leu Gln Cys Val Ser Leu Trp Leu 
        35                  40                  45              


Leu Gly Thr Ile Leu Ile Leu Cys Ser Val Asp Asn His Gly Leu Arg 
    50                  55                  60                  


Arg Cys Leu Ile Ser Thr Asp Met His His Ile Glu Glu Ser Phe Gln 
65                  70                  75                  80  


Glu Ile Lys Arg Ala Ile Gln Ala Lys Asp Thr Phe Pro Asn Val Thr 
                85                  90                  95      


Ile Leu Ser Thr Leu Glu Thr Leu Gln Ile Ile Lys Pro Leu Asp Val 
            100                 105                 110         


Cys Cys Val Thr Lys Asn Leu Leu Ala Phe Tyr Val Asp Arg Val Phe 
        115                 120                 125             


Lys Asp His Gln Glu Pro Asn Pro Lys Ile Leu Arg Lys Ile Ser Ser 
    130                 135                 140                 


Ile Ala Asn Ser Phe Leu Tyr Met Gln Lys Thr Leu Arg Gln Cys Gln 
145                 150                 155                 160 


Glu Gln Arg Gln Cys His Cys Arg Gln Glu Ala Thr Asn Ala Thr Arg 
                165                 170                 175     


Val Ile His Asp Asn Tyr Asp Gln Leu Glu Val His Ala Ala Ala Ile 
            180                 185                 190         


Lys Ser Leu Gly Glu Leu Asp Val Phe Leu Ala Trp Ile Asn Lys Asn 
        195                 200                 205             


His Glu Val Met Phe Ser Ala 
    210                 215 


<210>  6950
<211>  177
<212>  PRT
<213>  Homo Sapiens

<400>  6950

Met Lys Leu Gln Cys Val Ser Leu Trp Leu Leu Gly Thr Ile Leu Ile 
1               5                   10                  15      


Leu Cys Ser Val Asp Asn His Gly Leu Arg Arg Cys Leu Ile Ser Thr 
            20                  25                  30          


Asp Met His His Ile Glu Glu Ser Phe Gln Glu Ile Lys Arg Ala Ile 
        35                  40                  45              


Gln Ala Lys Asp Thr Phe Pro Asn Val Thr Ile Leu Ser Thr Leu Glu 
    50                  55                  60                  


Thr Leu Gln Ile Ile Lys Pro Leu Asp Val Cys Cys Val Thr Lys Asn 
65                  70                  75                  80  


Leu Leu Ala Phe Tyr Val Asp Arg Val Phe Lys Asp His Gln Glu Pro 
                85                  90                  95      


Asn Pro Lys Ile Leu Arg Lys Ile Ser Ser Ile Ala Asn Ser Phe Leu 
            100                 105                 110         


Tyr Met Gln Lys Thr Leu Arg Gln Cys Gln Glu Gln Arg Gln Cys His 
        115                 120                 125             


Cys Arg Gln Glu Ala Thr Asn Ala Thr Arg Val Ile His Asp Asn Tyr 
    130                 135                 140                 


Asp Gln Leu Glu Val His Ala Ala Ala Ile Lys Ser Leu Gly Glu Leu 
145                 150                 155                 160 


Asp Val Phe Leu Ala Trp Ile Asn Lys Asn His Glu Val Met Phe Ser 
                165                 170                 175     


Ala 
    


<210>  6951
<211>  177
<212>  PRT
<213>  Homo Sapiens

<400>  6951

Met Lys Leu Gln Cys Val Ser Leu Trp Leu Leu Gly Thr Ile Leu Ile 
1               5                   10                  15      


Leu Cys Ser Val Asp Asn His Gly Leu Arg Arg Cys Leu Ile Ser Thr 
            20                  25                  30          


Asp Met His His Ile Glu Glu Ser Phe Gln Glu Ile Lys Arg Ala Ile 
        35                  40                  45              


Gln Ala Lys Asp Thr Phe Pro Asn Val Thr Ile Leu Ser Thr Leu Glu 
    50                  55                  60                  


Thr Leu Gln Ile Ile Lys Pro Leu Asp Val Cys Cys Val Thr Lys Asn 
65                  70                  75                  80  


Leu Leu Ala Phe Tyr Val Asp Arg Val Phe Lys Asp His Gln Glu Pro 
                85                  90                  95      


Asn Pro Lys Ile Leu Arg Lys Ile Ser Ser Ile Ala Asn Ser Phe Leu 
            100                 105                 110         


Tyr Met Gln Lys Thr Leu Arg Gln Cys Gln Glu Gln Arg Gln Cys His 
        115                 120                 125             


Cys Arg Gln Glu Ala Thr Asn Ala Thr Arg Val Ile His Asp Asn Tyr 
    130                 135                 140                 


Asp Gln Leu Glu Val His Ala Ala Ala Ile Lys Ser Leu Gly Glu Leu 
145                 150                 155                 160 


Asp Val Phe Leu Ala Trp Ile Asn Lys Asn His Glu Val Met Phe Ser 
                165                 170                 175     


Ala 
    


<210>  6952
<211>  298
<212>  PRT
<213>  Homo Sapiens

<400>  6952

Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp 
1               5                   10                  15      


Tyr Lys Asp Cys Lys Pro Leu Leu Leu Asp Asn Ile His Phe Ser Gly 
            20                  25                  30          


Val Lys Asp Arg Leu Ile Val Met Asn Val Ala Glu Lys His Arg Gly 
        35                  40                  45              


Asn Tyr Thr Cys His Ala Ser Tyr Thr Tyr Leu Gly Lys Gln Tyr Pro 
    50                  55                  60                  


Ile Thr Arg Val Ile Glu Phe Ile Thr Leu Glu Glu Asn Lys Pro Thr 
65                  70                  75                  80  


Arg Pro Val Ile Val Ser Pro Ala Asn Glu Thr Met Glu Val Asp Leu 
                85                  90                  95      


Gly Ser Gln Ile Gln Leu Ile Cys Asn Val Thr Gly Gln Leu Ser Asp 
            100                 105                 110         


Ile Ala Tyr Trp Lys Trp Asn Gly Ser Val Ile Asp Glu Asp Asp Pro 
        115                 120                 125             


Val Leu Gly Glu Asp Tyr Tyr Ser Val Glu Asn Pro Ala Asn Lys Arg 
    130                 135                 140                 


Arg Ser Thr Leu Ile Thr Val Leu Asn Ile Ser Glu Ile Glu Ser Arg 
145                 150                 155                 160 


Phe Tyr Lys His Pro Phe Thr Cys Phe Ala Lys Asn Thr His Gly Ile 
                165                 170                 175     


Asp Ala Ala Tyr Ile Gln Leu Ile Tyr Pro Val Thr Asn Phe Gln Lys 
            180                 185                 190         


His Met Ile Gly Ile Cys Val Thr Leu Thr Val Ile Ile Val Cys Ser 
        195                 200                 205             


Val Phe Ile Tyr Lys Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
    210                 215                 220                 


Asp Ser Cys Tyr Asp Phe Leu Pro Ile Lys Ala Ser Asp Gly Lys Thr 
225                 230                 235                 240 


Tyr Asp Ala Tyr Ile Leu Tyr Pro Lys Thr Val Gly Glu Gly Ser Thr 
                245                 250                 255     


Ser Asp Cys Asp Ile Phe Val Phe Lys Val Leu Pro Glu Val Leu Glu 
            260                 265                 270         


Lys Gln Cys Gly Tyr Lys Leu Phe Ile Tyr Gly Arg Asp Asp Tyr Val 
        275                 280                 285             


Gly Glu Asp Ile Val Glu Val Ile Asn Glu 
    290                 295             


<210>  6953
<211>  80
<212>  PRT
<213>  Homo Sapiens

<400>  6953

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


<210>  6954
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  6954

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Ile Ala Asn Leu Tyr Phe Leu Thr Ile Tyr Thr Leu Val 
            100                 105                 110         


Glu Ser Lys Ile Gly Ser Ser 
        115                 


<210>  6955
<211>  106
<212>  PRT
<213>  Homo Sapiens

<400>  6955

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg 
            100                 105     


<210>  6956
<211>  114
<212>  PRT
<213>  Homo Sapiens

<400>  6956

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys 
            100                 105                 110         


Phe Val 
        


<210>  6957
<211>  182
<212>  PRT
<213>  Homo Sapiens

<400>  6957

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys 
            100                 105                 110         


Phe Val Glu Asn Glu Pro Asn Leu Cys Tyr Asn Ala Gln Ala Ile Phe 
        115                 120                 125             


Lys Gln Lys Leu Pro Val Ala Gly Asp Gly Gly Leu Val Cys Pro Tyr 
    130                 135                 140                 


Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp 
145                 150                 155                 160 


Tyr Lys Asp Cys Lys Pro Leu Leu Leu Asp Asn Ile His Phe Ser Gly 
                165                 170                 175     


Val Lys Asp Arg Leu Ile 
            180         


<210>  6958
<211>  447
<212>  PRT
<213>  Homo Sapiens

<400>  6958

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys 
            100                 105                 110         


Phe Val Glu Asn Glu Pro Asn Leu Cys Tyr Asn Ala Gln Ala Ile Phe 
        115                 120                 125             


Lys Gln Lys Leu Pro Val Ala Gly Asp Gly Gly Leu Val Cys Pro Tyr 
    130                 135                 140                 


Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp 
145                 150                 155                 160 


Tyr Lys Asp Cys Lys Pro Leu Leu Leu Asp Asn Ile His Phe Ser Gly 
                165                 170                 175     


Val Lys Asp Arg Leu Ile Val Met Asn Val Ala Glu Lys His Arg Gly 
            180                 185                 190         


Asn Tyr Thr Cys His Ala Ser Tyr Thr Tyr Leu Gly Lys Gln Tyr Pro 
        195                 200                 205             


Ile Thr Arg Val Ile Glu Phe Ile Thr Leu Glu Glu Asn Lys Pro Thr 
    210                 215                 220                 


Arg Pro Val Ile Val Ser Pro Ala Asn Glu Thr Met Glu Val Asp Leu 
225                 230                 235                 240 


Gly Ser Gln Ile Gln Leu Ile Cys Asn Val Thr Gly Gln Leu Ser Asp 
                245                 250                 255     


Ile Ala Tyr Trp Lys Trp Asn Gly Ser Val Ile Asp Glu Asp Asp Pro 
            260                 265                 270         


Val Leu Gly Glu Asp Tyr Tyr Ser Val Glu Asn Pro Ala Asn Lys Arg 
        275                 280                 285             


Arg Ser Thr Leu Ile Thr Val Leu Asn Ile Ser Glu Ile Glu Ser Arg 
    290                 295                 300                 


Phe Tyr Lys His Pro Phe Thr Cys Phe Ala Lys Asn Thr His Gly Ile 
305                 310                 315                 320 


Asp Ala Ala Tyr Ile Gln Leu Ile Tyr Pro Val Thr Asn Phe Gln Lys 
                325                 330                 335     


His Met Ile Gly Ile Cys Val Thr Leu Thr Val Ile Ile Val Cys Ser 
            340                 345                 350         


Val Phe Ile Tyr Lys Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             


Asp Ser Cys Tyr Asp Phe Leu Pro Ile Lys Ala Ser Asp Gly Lys Thr 
    370                 375                 380                 


Tyr Asp Ala Tyr Ile Leu Tyr Pro Lys Thr Val Gly Glu Gly Ser Thr 
385                 390                 395                 400 


Ser Asp Cys Asp Ile Phe Val Phe Lys Val Leu Pro Glu Val Leu Glu 
                405                 410                 415     


Lys Gln Cys Gly Tyr Lys Leu Phe Ile Tyr Gly Arg Asp Asp Tyr Val 
            420                 425                 430         


Gly Glu Gly Met Cys Val Met Glu Gln Ser Lys Gly Leu Leu Leu 
        435                 440                 445         


<210>  6959
<211>  447
<212>  PRT
<213>  Homo Sapiens

<400>  6959

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys 
            100                 105                 110         


Phe Val Glu Asn Glu Pro Asn Leu Cys Tyr Asn Ala Gln Ala Ile Phe 
        115                 120                 125             


Lys Gln Lys Leu Pro Val Ala Gly Asp Gly Gly Leu Val Cys Pro Tyr 
    130                 135                 140                 


Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp 
145                 150                 155                 160 


Tyr Lys Asp Cys Lys Pro Leu Leu Leu Asp Asn Ile His Phe Ser Gly 
                165                 170                 175     


Val Lys Asp Arg Leu Ile Val Met Asn Val Ala Glu Lys His Arg Gly 
            180                 185                 190         


Asn Tyr Thr Cys His Ala Ser Tyr Thr Tyr Leu Gly Lys Gln Tyr Pro 
        195                 200                 205             


Ile Thr Arg Val Ile Glu Phe Ile Thr Leu Glu Glu Asn Lys Pro Thr 
    210                 215                 220                 


Arg Pro Val Ile Val Ser Pro Ala Asn Glu Thr Met Glu Val Asp Leu 
225                 230                 235                 240 


Gly Ser Gln Ile Gln Leu Ile Cys Asn Val Thr Gly Gln Leu Ser Asp 
                245                 250                 255     


Ile Ala Tyr Trp Lys Trp Asn Gly Ser Val Ile Asp Glu Asp Asp Pro 
            260                 265                 270         


Val Leu Gly Glu Asp Tyr Tyr Ser Val Glu Asn Pro Ala Asn Lys Arg 
        275                 280                 285             


Arg Ser Thr Leu Ile Thr Val Leu Asn Ile Ser Glu Ile Glu Ser Arg 
    290                 295                 300                 


Phe Tyr Lys His Pro Phe Thr Cys Phe Ala Lys Asn Thr His Gly Ile 
305                 310                 315                 320 


Asp Ala Ala Tyr Ile Gln Leu Ile Tyr Pro Val Thr Asn Phe Gln Lys 
                325                 330                 335     


His Met Ile Gly Ile Cys Val Thr Leu Thr Val Ile Ile Val Cys Ser 
            340                 345                 350         


Val Phe Ile Tyr Lys Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             


Asp Ser Cys Tyr Asp Phe Leu Pro Ile Lys Ala Ser Asp Gly Lys Thr 
    370                 375                 380                 


Tyr Asp Ala Tyr Ile Leu Tyr Pro Lys Thr Val Gly Glu Gly Ser Thr 
385                 390                 395                 400 


Ser Asp Cys Asp Ile Phe Val Phe Lys Val Leu Pro Glu Val Leu Glu 
                405                 410                 415     


Lys Gln Cys Gly Tyr Lys Leu Phe Ile Tyr Gly Arg Asp Asp Tyr Val 
            420                 425                 430         


Gly Glu Gly Met Cys Val Met Glu Gln Ser Lys Gly Leu Leu Leu 
        435                 440                 445         


<210>  6960
<211>  538
<212>  PRT
<213>  Homo Sapiens

<400>  6960

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys 
            100                 105                 110         


Phe Val Glu Asn Glu Pro Asn Leu Cys Tyr Asn Ala Gln Ala Ile Phe 
        115                 120                 125             


Lys Gln Lys Leu Pro Val Ala Gly Asp Gly Gly Leu Val Cys Pro Tyr 
    130                 135                 140                 


Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp 
145                 150                 155                 160 


Tyr Lys Asp Cys Lys Pro Leu Leu Leu Asp Asn Ile His Phe Ser Gly 
                165                 170                 175     


Val Lys Asp Arg Leu Ile Val Met Asn Val Ala Glu Lys His Arg Gly 
            180                 185                 190         


Asn Tyr Thr Cys His Ala Ser Tyr Thr Tyr Leu Gly Lys Gln Tyr Pro 
        195                 200                 205             


Ile Thr Arg Val Ile Glu Phe Ile Thr Leu Glu Glu Asn Lys Pro Thr 
    210                 215                 220                 


Arg Pro Val Ile Val Ser Pro Ala Asn Glu Thr Met Glu Val Asp Leu 
225                 230                 235                 240 


Gly Ser Gln Ile Gln Leu Ile Cys Asn Val Thr Gly Gln Leu Ser Asp 
                245                 250                 255     


Ile Ala Tyr Trp Lys Trp Asn Gly Ser Val Ile Asp Glu Asp Asp Pro 
            260                 265                 270         


Val Leu Gly Glu Asp Tyr Tyr Ser Val Glu Asn Pro Ala Asn Lys Arg 
        275                 280                 285             


Arg Ser Thr Leu Ile Thr Val Leu Asn Ile Ser Glu Ile Glu Ser Arg 
    290                 295                 300                 


Phe Tyr Lys His Pro Phe Thr Cys Phe Ala Lys Asn Thr His Gly Ile 
305                 310                 315                 320 


Asp Ala Ala Tyr Ile Gln Leu Ile Tyr Pro Val Thr Asn Phe Gln Lys 
                325                 330                 335     


His Met Ile Gly Ile Cys Val Thr Leu Thr Val Ile Ile Val Cys Ser 
            340                 345                 350         


Val Phe Ile Tyr Lys Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             


Asp Ser Cys Tyr Asp Phe Leu Pro Ile Lys Val Leu Pro Glu Val Leu 
    370                 375                 380                 


Glu Lys Gln Cys Gly Tyr Lys Leu Phe Ile Tyr Gly Arg Asp Asp Tyr 
385                 390                 395                 400 


Val Gly Glu Asp Ile Val Glu Val Ile Asn Glu Asn Val Lys Lys Ser 
                405                 410                 415     


Arg Arg Leu Ile Ile Ile Leu Val Arg Glu Thr Ser Gly Phe Ser Trp 
            420                 425                 430         


Leu Gly Gly Ser Ser Glu Glu Gln Ile Ala Met Tyr Asn Ala Leu Val 
        435                 440                 445             


Gln Asp Gly Ile Lys Val Val Leu Leu Glu Leu Glu Lys Ile Gln Asp 
    450                 455                 460                 


Tyr Glu Lys Met Pro Glu Ser Ile Lys Phe Ile Lys Gln Lys His Gly 
465                 470                 475                 480 


Ala Ile Arg Trp Ser Gly Asp Phe Thr Gln Gly Pro Gln Ser Ala Lys 
                485                 490                 495     


Thr Arg Phe Trp Lys Asn Val Arg Tyr His Met Pro Val Gln Arg Arg 
            500                 505                 510         


Ser Pro Ser Ser Lys His Gln Leu Leu Ser Pro Ala Thr Lys Glu Lys 
        515                 520                 525             


Leu Gln Arg Glu Ala His Val Pro Leu Gly 
    530                 535             


<210>  6961
<211>  447
<212>  PRT
<213>  Homo Sapiens

<400>  6961

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys 
            100                 105                 110         


Phe Val Glu Asn Glu Pro Asn Leu Cys Tyr Asn Ala Gln Ala Ile Phe 
        115                 120                 125             


Lys Gln Lys Leu Pro Val Ala Gly Asp Gly Gly Leu Val Cys Pro Tyr 
    130                 135                 140                 


Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp 
145                 150                 155                 160 


Tyr Lys Asp Cys Lys Pro Leu Leu Leu Asp Asn Ile His Phe Ser Gly 
                165                 170                 175     


Val Lys Asp Arg Leu Ile Val Met Asn Val Ala Glu Lys His Arg Gly 
            180                 185                 190         


Asn Tyr Thr Cys His Ala Ser Tyr Thr Tyr Leu Gly Lys Gln Tyr Pro 
        195                 200                 205             


Ile Thr Arg Val Ile Glu Phe Ile Thr Leu Glu Glu Asn Lys Pro Thr 
    210                 215                 220                 


Arg Pro Val Ile Val Ser Pro Ala Asn Glu Thr Met Glu Val Asp Leu 
225                 230                 235                 240 


Gly Ser Gln Ile Gln Leu Ile Cys Asn Val Thr Gly Gln Leu Ser Asp 
                245                 250                 255     


Ile Ala Tyr Trp Lys Trp Asn Gly Ser Val Ile Asp Glu Asp Asp Pro 
            260                 265                 270         


Val Leu Gly Glu Asp Tyr Tyr Ser Val Glu Asn Pro Ala Asn Lys Arg 
        275                 280                 285             


Arg Ser Thr Leu Ile Thr Val Leu Asn Ile Ser Glu Ile Glu Ser Arg 
    290                 295                 300                 


Phe Tyr Lys His Pro Phe Thr Cys Phe Ala Lys Asn Thr His Gly Ile 
305                 310                 315                 320 


Asp Ala Ala Tyr Ile Gln Leu Ile Tyr Pro Val Thr Asn Phe Gln Lys 
                325                 330                 335     


His Met Ile Gly Ile Cys Val Thr Leu Thr Val Ile Ile Val Cys Ser 
            340                 345                 350         


Val Phe Ile Tyr Lys Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             


Asp Ser Cys Tyr Asp Phe Leu Pro Ile Lys Ala Ser Asp Gly Lys Thr 
    370                 375                 380                 


Tyr Asp Ala Tyr Ile Leu Tyr Pro Lys Thr Val Gly Glu Gly Ser Thr 
385                 390                 395                 400 


Ser Asp Cys Asp Ile Phe Val Phe Lys Val Leu Pro Glu Val Leu Glu 
                405                 410                 415     


Lys Gln Cys Gly Tyr Lys Leu Phe Ile Tyr Gly Arg Asp Asp Tyr Val 
            420                 425                 430         


Gly Glu Gly Met Cys Val Met Glu Gln Ser Lys Gly Leu Leu Leu 
        435                 440                 445         


<210>  6962
<211>  569
<212>  PRT
<213>  Homo Sapiens

<400>  6962

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys 
            100                 105                 110         


Phe Val Glu Asn Glu Pro Asn Leu Cys Tyr Asn Ala Gln Ala Ile Phe 
        115                 120                 125             


Lys Gln Lys Leu Pro Val Ala Gly Asp Gly Gly Leu Val Cys Pro Tyr 
    130                 135                 140                 


Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp 
145                 150                 155                 160 


Tyr Lys Asp Cys Lys Pro Leu Leu Leu Asp Asn Ile His Phe Ser Gly 
                165                 170                 175     


Val Lys Asp Arg Leu Ile Val Met Asn Val Ala Glu Lys His Arg Gly 
            180                 185                 190         


Asn Tyr Thr Cys His Ala Ser Tyr Thr Tyr Leu Gly Lys Gln Tyr Pro 
        195                 200                 205             


Ile Thr Arg Val Ile Glu Phe Ile Thr Leu Glu Glu Asn Lys Pro Thr 
    210                 215                 220                 


Arg Pro Val Ile Val Ser Pro Ala Asn Glu Thr Met Glu Val Asp Leu 
225                 230                 235                 240 


Gly Ser Gln Ile Gln Leu Ile Cys Asn Val Thr Gly Gln Leu Ser Asp 
                245                 250                 255     


Ile Ala Tyr Trp Lys Trp Asn Gly Ser Val Ile Asp Glu Asp Asp Pro 
            260                 265                 270         


Val Leu Gly Glu Asp Tyr Tyr Ser Val Glu Asn Pro Ala Asn Lys Arg 
        275                 280                 285             


Arg Ser Thr Leu Ile Thr Val Leu Asn Ile Ser Glu Ile Glu Ser Arg 
    290                 295                 300                 


Phe Tyr Lys His Pro Phe Thr Cys Phe Ala Lys Asn Thr His Gly Ile 
305                 310                 315                 320 


Asp Ala Ala Tyr Ile Gln Leu Ile Tyr Pro Val Thr Asn Phe Gln Lys 
                325                 330                 335     


His Met Ile Gly Ile Cys Val Thr Leu Thr Val Ile Ile Val Cys Ser 
            340                 345                 350         


Val Phe Ile Tyr Lys Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             


Asp Ser Cys Tyr Asp Phe Leu Pro Ile Lys Ala Ser Asp Gly Lys Thr 
    370                 375                 380                 


Tyr Asp Ala Tyr Ile Leu Tyr Pro Lys Thr Val Gly Glu Gly Ser Thr 
385                 390                 395                 400 


Ser Asp Cys Asp Ile Phe Val Phe Lys Val Leu Pro Glu Val Leu Glu 
                405                 410                 415     


Lys Gln Cys Gly Tyr Lys Leu Phe Ile Tyr Gly Arg Asp Asp Tyr Val 
            420                 425                 430         


Gly Glu Asp Ile Val Glu Val Ile Asn Glu Asn Val Lys Lys Ser Arg 
        435                 440                 445             


Arg Leu Ile Ile Ile Leu Val Arg Glu Thr Ser Gly Phe Ser Trp Leu 
    450                 455                 460                 


Gly Gly Ser Ser Glu Glu Gln Ile Ala Met Tyr Asn Ala Leu Val Gln 
465                 470                 475                 480 


Asp Gly Ile Lys Val Val Leu Leu Glu Leu Glu Lys Ile Gln Asp Tyr 
                485                 490                 495     


Glu Lys Met Pro Glu Ser Ile Lys Phe Ile Lys Gln Lys His Gly Ala 
            500                 505                 510         


Ile Arg Trp Ser Gly Asp Phe Thr Gln Gly Pro Gln Ser Ala Lys Thr 
        515                 520                 525             


Arg Phe Trp Lys Asn Val Arg Tyr His Met Pro Val Gln Arg Arg Ser 
    530                 535                 540                 


Pro Ser Ser Lys His Gln Leu Leu Ser Pro Ala Thr Lys Glu Lys Leu 
545                 550                 555                 560 


Gln Arg Glu Ala His Val Pro Leu Gly 
                565                 


<210>  6963
<211>  173
<212>  PRT
<213>  Homo Sapiens

<400>  6963

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys 
            100                 105                 110         


Phe Val Glu Asn Glu Pro Asn Leu Cys Tyr Asn Ala Gln Ala Ile Phe 
        115                 120                 125             


Lys Gln Lys Leu Pro Val Ala Gly Asp Gly Gly Leu Val Cys Pro Tyr 
    130                 135                 140                 


Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp 
145                 150                 155                 160 


Tyr Lys Val Ala Val Ser Arg Val Trp Ala Thr Ala Leu 
                165                 170             


<210>  6964
<211>  124
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6964

Xaa Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu Val Ser Ser Ala 
1               5                   10                  15      


Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro Asn Glu His Lys 
            20                  25                  30          


Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr Pro Val Ser Thr 
        35                  40                  45              


Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys Leu Trp Phe Val 
    50                  55                  60                  


Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys Val Glu Thr Glu 
65                  70                  75                  80  


Asp Leu Cys Ala Leu Ile Trp Ser Phe Leu Lys Met Lys Ile Met Ser 
                85                  90                  95      


Tyr Leu Asn Tyr Ser Gly Ile Arg Ile Ala Asn Leu Tyr Phe Leu Thr 
            100                 105                 110         


Ile Tyr Thr Leu Val Glu Ser Lys Ile Gly Ser Ser 
        115                 120                 


<210>  6965
<211>  229
<212>  PRT
<213>  Homo Sapiens

<400>  6965

Met Leu Arg Leu Tyr Val Leu Val Met Gly Val Ser Ala Phe Thr Leu 
1               5                   10                  15      


Gln Pro Ala Ala His Thr Gly Ala Ala Arg Ser Cys Arg Phe Arg Gly 
            20                  25                  30          


Arg His Tyr Lys Arg Glu Phe Arg Leu Glu Gly Glu Pro Val Ala Leu 
        35                  40                  45              


Arg Cys Pro Gln Val Pro Tyr Trp Leu Trp Ala Ser Val Ser Pro Arg 
    50                  55                  60                  


Ile Asn Leu Thr Trp His Lys Asn Asp Ser Ala Arg Thr Val Pro Gly 
65                  70                  75                  80  


Glu Glu Glu Thr Arg Met Trp Ala Gln Asp Gly Ala Leu Trp Leu Leu 
                85                  90                  95      


Pro Ala Leu Gln Glu Asp Ser Gly Thr Tyr Val Cys Thr Thr Arg Asn 
            100                 105                 110         


Ala Ser Tyr Cys Asp Lys Met Ser Ile Glu Leu Arg Val Phe Glu Asn 
        115                 120                 125             


Thr Asp Ala Phe Leu Pro Phe Ile Ser Tyr Pro Gln Ile Leu Thr Leu 
    130                 135                 140                 


Ser Thr Ser Gly Val Leu Val Cys Pro Asp Leu Ser Glu Phe Thr Arg 
145                 150                 155                 160 


Asp Lys Thr Asp Val Lys Ile Gln Trp Tyr Lys Asp Ser Leu Leu Leu 
                165                 170                 175     


Asp Lys Asp Asn Glu Lys Phe Leu Ser Val Arg Gly Thr Thr His Leu 
            180                 185                 190         


Leu Val His Asp Val Ala Leu Glu Asp Ala Gly Tyr Tyr Arg Cys Val 
        195                 200                 205             


Leu Thr Phe Ala His Glu Gly Gln Gln Tyr Asn Ile Thr Arg Ser Ile 
    210                 215                 220                 


Glu Leu Arg Ile Lys 
225                 


<210>  6966
<211>  398
<212>  PRT
<213>  Homo Sapiens

<400>  6966

Met Leu Arg Leu Tyr Val Leu Val Met Gly Val Ser Ala Phe Thr Leu 
1               5                   10                  15      


Gln Pro Ala Ala His Thr Gly Ala Ala Arg Ser Cys Arg Phe Arg Gly 
            20                  25                  30          


Arg His Tyr Lys Arg Glu Phe Arg Leu Glu Gly Glu Pro Val Ala Leu 
        35                  40                  45              


Arg Cys Pro Gln Val Pro Tyr Trp Leu Trp Ala Ser Val Ser Pro Arg 
    50                  55                  60                  


Ile Asn Leu Thr Trp His Lys Asn Asp Ser Ala Arg Thr Val Pro Gly 
65                  70                  75                  80  


Glu Glu Glu Thr Arg Met Trp Ala Gln Asp Gly Ala Leu Trp Leu Leu 
                85                  90                  95      


Pro Ala Leu Gln Glu Asp Ser Gly Thr Tyr Val Cys Thr Thr Arg Asn 
            100                 105                 110         


Ala Ser Tyr Cys Asp Lys Met Ser Ile Glu Leu Arg Val Phe Glu Asn 
        115                 120                 125             


Thr Asp Ala Phe Leu Pro Phe Ile Ser Tyr Pro Gln Ile Leu Thr Leu 
    130                 135                 140                 


Ser Thr Ser Gly Val Leu Val Cys Pro Asp Leu Ser Glu Phe Thr Arg 
145                 150                 155                 160 


Asp Lys Thr Asp Val Lys Ile Gln Trp Tyr Lys Asp Ser Leu Leu Leu 
                165                 170                 175     


Asp Lys Asp Asn Glu Lys Phe Leu Ser Val Arg Gly Thr Thr His Leu 
            180                 185                 190         


Leu Val His Asp Val Ala Leu Glu Asp Ala Gly Tyr Tyr Arg Cys Val 
        195                 200                 205             


Leu Thr Phe Ala His Glu Gly Gln Gln Tyr Asn Ile Thr Arg Ser Ile 
    210                 215                 220                 


Glu Leu Arg Ile Lys Lys Lys Lys Glu Glu Thr Ile Pro Val Ile Ile 
225                 230                 235                 240 


Ser Pro Leu Lys Thr Ile Ser Ala Ser Leu Gly Ser Arg Leu Thr Ile 
                245                 250                 255     


Pro Cys Lys Val Phe Leu Gly Thr Gly Thr Pro Leu Thr Thr Met Leu 
            260                 265                 270         


Trp Trp Thr Ala Asn Asp Thr His Ile Glu Ser Ala Tyr Pro Gly Gly 
        275                 280                 285             


Arg Val Thr Glu Gly Pro Arg Gln Glu Tyr Ser Glu Asn Asn Glu Asn 
    290                 295                 300                 


Tyr Ile Glu Val Pro Leu Ile Phe Asp Pro Val Thr Arg Glu Asp Leu 
305                 310                 315                 320 


His Met Asp Phe Lys Cys Val Val His Asn Thr Leu Ser Phe Gln Thr 
                325                 330                 335     


Leu Arg Thr Thr Val Lys Glu Ala Ser Ser Thr Phe Ser Trp Gly Ile 
            340                 345                 350         


Val Leu Ala Pro Leu Ser Leu Ala Phe Leu Val Leu Gly Gly Ile Trp 
        355                 360                 365             


Met His Arg Arg Cys Lys His Arg Thr Gly Lys Ala Asp Gly Leu Thr 
    370                 375                 380                 


Val Leu Trp Pro His His Gln Asp Phe Gln Ser Tyr Pro Lys 
385                 390                 395             


<210>  6967
<211>  398
<212>  PRT
<213>  Homo Sapiens

<400>  6967

Met Leu Arg Leu Tyr Val Leu Val Met Gly Val Ser Ala Phe Thr Leu 
1               5                   10                  15      


Gln Pro Ala Ala His Thr Gly Ala Ala Arg Ser Cys Arg Phe Arg Gly 
            20                  25                  30          


Arg His Tyr Lys Arg Glu Phe Arg Leu Glu Gly Glu Pro Val Ala Leu 
        35                  40                  45              


Arg Cys Pro Gln Val Pro Tyr Trp Leu Trp Ala Ser Val Ser Pro Arg 
    50                  55                  60                  


Ile Asn Leu Thr Trp His Lys Asn Asp Ser Ala Arg Thr Val Pro Gly 
65                  70                  75                  80  


Glu Glu Glu Thr Arg Met Trp Ala Gln Asp Gly Ala Leu Trp Leu Leu 
                85                  90                  95      


Pro Ala Leu Gln Glu Asp Ser Gly Thr Tyr Val Cys Thr Thr Arg Asn 
            100                 105                 110         


Ala Ser Tyr Cys Asp Lys Met Ser Ile Glu Leu Arg Val Phe Glu Asn 
        115                 120                 125             


Thr Asp Ala Phe Leu Pro Phe Ile Ser Tyr Pro Gln Ile Leu Thr Leu 
    130                 135                 140                 


Ser Thr Ser Gly Val Leu Val Cys Pro Asp Leu Ser Glu Phe Thr Arg 
145                 150                 155                 160 


Asp Lys Thr Asp Val Lys Ile Gln Trp Tyr Lys Asp Ser Leu Leu Leu 
                165                 170                 175     


Asp Lys Asp Asn Glu Lys Phe Leu Ser Val Arg Gly Thr Thr His Leu 
            180                 185                 190         


Leu Val His Asp Val Ala Leu Glu Asp Ala Gly Tyr Tyr Arg Cys Val 
        195                 200                 205             


Leu Thr Phe Ala His Glu Gly Gln Gln Tyr Asn Ile Thr Arg Ser Ile 
    210                 215                 220                 


Glu Leu Arg Ile Lys Lys Lys Lys Glu Glu Thr Ile Pro Val Ile Ile 
225                 230                 235                 240 


Ser Pro Leu Lys Thr Ile Ser Ala Ser Leu Gly Ser Arg Leu Thr Ile 
                245                 250                 255     


Pro Cys Lys Val Phe Leu Gly Thr Gly Thr Pro Leu Thr Thr Met Leu 
            260                 265                 270         


Trp Trp Thr Ala Asn Asp Thr His Ile Glu Ser Ala Tyr Pro Gly Gly 
        275                 280                 285             


Arg Val Thr Glu Gly Pro Arg Gln Glu Tyr Ser Glu Asn Asn Glu Asn 
    290                 295                 300                 


Tyr Ile Glu Val Pro Leu Ile Phe Asp Pro Val Thr Arg Glu Asp Leu 
305                 310                 315                 320 


His Met Asp Phe Lys Cys Val Val His Asn Thr Leu Ser Phe Gln Thr 
                325                 330                 335     


Leu Arg Thr Thr Val Lys Glu Ala Ser Ser Thr Phe Ser Trp Gly Ile 
            340                 345                 350         


Val Leu Ala Pro Leu Ser Leu Ala Phe Leu Val Leu Gly Gly Ile Trp 
        355                 360                 365             


Met His Arg Arg Cys Lys His Arg Thr Gly Lys Ala Asp Gly Leu Thr 
    370                 375                 380                 


Val Leu Trp Pro His His Gln Asp Phe Gln Ser Tyr Pro Lys 
385                 390                 395             


<210>  6968
<211>  296
<212>  PRT
<213>  Homo Sapiens

<400>  6968

Met Leu Arg Leu Tyr Val Leu Val Met Gly Val Ser Ala Phe Thr Leu 
1               5                   10                  15      


Gln Pro Ala Ala His Thr Gly Ala Ala Arg Ser Cys Arg Phe Arg Gly 
            20                  25                  30          


Arg His Tyr Lys Arg Glu Phe Arg Leu Glu Gly Glu Pro Val Ala Leu 
        35                  40                  45              


Arg Cys Pro Gln Val Pro Tyr Trp Leu Trp Ala Ser Val Ser Pro Arg 
    50                  55                  60                  


Ile Asn Leu Thr Trp His Lys Asn Asp Ser Ala Arg Thr Val Pro Gly 
65                  70                  75                  80  


Glu Glu Glu Thr Arg Met Trp Ala Gln Asp Gly Ala Leu Trp Leu Leu 
                85                  90                  95      


Pro Ala Leu Gln Glu Asp Ser Gly Thr Tyr Val Cys Thr Thr Arg Asn 
            100                 105                 110         


Ala Ser Tyr Cys Asp Lys Met Ser Ile Glu Leu Arg Val Phe Glu Asn 
        115                 120                 125             


Thr Asp Ala Phe Leu Pro Phe Ile Ser Tyr Pro Gln Ile Leu Thr Leu 
    130                 135                 140                 


Ser Thr Ser Gly Val Leu Val Cys Pro Asp Leu Ser Glu Phe Thr Arg 
145                 150                 155                 160 


Asp Lys Thr Asp Val Lys Ile Gln Trp Tyr Lys Asp Ser Leu Leu Leu 
                165                 170                 175     


Asp Lys Asp Asn Glu Lys Phe Leu Ser Val Arg Gly Thr Thr His Leu 
            180                 185                 190         


Leu Val His Asp Val Ala Leu Glu Asp Ala Gly Tyr Tyr Arg Cys Val 
        195                 200                 205             


Leu Thr Phe Ala His Glu Gly Gln Gln Tyr Asn Ile Thr Arg Ser Ile 
    210                 215                 220                 


Glu Leu Arg Ile Lys Lys Lys Lys Glu Glu Thr Ile Pro Val Ile Ile 
225                 230                 235                 240 


Ser Pro Leu Lys Thr Ile Ser Ala Ser Leu Gly Ser Arg Leu Thr Ile 
                245                 250                 255     


Pro Cys Lys Val Phe Leu Gly Thr Gly Thr Pro Leu Thr Thr Met Leu 
            260                 265                 270         


Trp Trp Thr Ala Asn Asp Thr His Ile Glu Ser Ala Tyr Pro Gly Gly 
        275                 280                 285             


Arg Val Thr Glu Gly Pro Arg Gln 
    290                 295     


<210>  6969
<211>  215
<212>  PRT
<213>  Homo Sapiens

<400>  6969

Met Lys Leu Pro Val His Lys Leu Tyr Ile Glu Tyr Gly Ile Gln Arg 
1               5                   10                  15      


Ile Thr Cys Pro Asn Val Asp Gly Tyr Phe Pro Ser Ser Val Lys Pro 
            20                  25                  30          


Thr Ile Thr Trp Tyr Met Gly Cys Tyr Lys Ile Gln Asn Phe Asn Asn 
        35                  40                  45              


Val Ile Pro Glu Gly Met Asn Leu Ser Phe Leu Ile Ala Leu Ile Ser 
    50                  55                  60                  


Asn Asn Gly Asn Tyr Thr Cys Val Val Thr Tyr Pro Glu Asn Gly Arg 
65                  70                  75                  80  


Thr Phe His Leu Thr Arg Thr Leu Thr Val Lys Val Val Gly Ser Pro 
                85                  90                  95      


Lys Asn Ala Val Pro Pro Val Ile His Ser Pro Asn Asp His Val Val 
            100                 105                 110         


Tyr Glu Lys Glu Pro Gly Glu Glu Leu Leu Ile Pro Cys Thr Val Tyr 
        115                 120                 125             


Phe Ser Phe Leu Met Asp Ser Arg Asn Glu Val Trp Trp Thr Ile Asp 
    130                 135                 140                 


Gly Lys Lys Pro Asp Asp Ile Thr Ile Asp Val Thr Ile Asn Glu Ser 
145                 150                 155                 160 


Ile Ser His Ser Arg Thr Glu Asp Glu Thr Arg Thr Gln Ile Leu Ser 
                165                 170                 175     


Ile Lys Lys Val Thr Ser Glu Asp Leu Lys Arg Ser Tyr Val Cys His 
            180                 185                 190         


Ala Arg Ser Ala Lys Gly Glu Val Ala Lys Ala Ala Lys Val Lys Gln 
        195                 200                 205             


Lys Gly Asn Arg Cys Gly Gln 
    210                 215 


<210>  6970
<211>  113
<212>  PRT
<213>  Homo Sapiens

<400>  6970

Met Thr Leu Leu Trp Cys Val Val Ser Leu Tyr Phe Tyr Gly Ile Leu 
1               5                   10                  15      


Gln Ser Asp Ala Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met 
            20                  25                  30          


Arg Gln Ile Gln Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro 
        35                  40                  45              


Leu Phe Glu His Phe Leu Lys Phe Asn Tyr Ser Thr Ala His Ser Ala 
    50                  55                  60                  


Gly Leu Thr Leu Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu 
65                  70                  75                  80  


Glu Pro Ile Asn Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys 
                85                  90                  95      


Asp Val Leu Trp Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr 
            100                 105                 110         


Thr 
    


<210>  6971
<211>  145
<212>  PRT
<213>  Homo Sapiens

<400>  6971

Met Thr Leu Leu Trp Cys Val Val Ser Leu Tyr Phe Tyr Gly Ile Leu 
1               5                   10                  15      


Gln Ser Asp Ala Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met 
            20                  25                  30          


Arg Gln Ile Gln Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro 
        35                  40                  45              


Leu Phe Glu His Phe Leu Lys Phe Asn Tyr Ser Thr Ala His Ser Ala 
    50                  55                  60                  


Gly Leu Thr Leu Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu 
65                  70                  75                  80  


Glu Pro Ile Asn Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys 
                85                  90                  95      


Asp Val Leu Trp Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Met Leu Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro 
        115                 120                 125             


Leu Glu Val Val Gln Lys Asp Ser Cys Phe Asn Ser Pro Met Lys Leu 
    130                 135                 140                 


Pro 
145 


<210>  6972
<211>  570
<212>  PRT
<213>  Homo Sapiens

<400>  6972

Met Thr Leu Leu Trp Cys Val Val Ser Leu Tyr Phe Tyr Gly Ile Leu 
1               5                   10                  15      


Gln Ser Asp Ala Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met 
            20                  25                  30          


Arg Gln Ile Gln Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro 
        35                  40                  45              


Leu Phe Glu His Phe Leu Lys Phe Asn Tyr Ser Thr Ala His Ser Ala 
    50                  55                  60                  


Gly Leu Thr Leu Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu 
65                  70                  75                  80  


Glu Pro Ile Asn Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys 
                85                  90                  95      


Asp Val Leu Trp Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Met Leu Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro 
        115                 120                 125             


Leu Glu Val Val Gln Lys Asp Ser Cys Phe Asn Ser Pro Met Lys Leu 
    130                 135                 140                 


Pro Val His Lys Leu Tyr Ile Glu Tyr Gly Ile Gln Arg Ile Thr Cys 
145                 150                 155                 160 


Pro Asn Val Asp Gly Tyr Phe Pro Ser Ser Val Lys Pro Thr Ile Thr 
                165                 170                 175     


Trp Tyr Met Gly Cys Tyr Lys Ile Gln Asn Phe Asn Asn Val Ile Pro 
            180                 185                 190         


Glu Gly Met Asn Leu Ser Phe Leu Ile Ala Leu Ile Ser Asn Asn Gly 
        195                 200                 205             


Asn Tyr Thr Cys Val Val Thr Tyr Pro Glu Asn Gly Arg Thr Phe His 
    210                 215                 220                 


Leu Thr Arg Thr Leu Thr Val Lys Val Val Gly Ser Pro Lys Asn Ala 
225                 230                 235                 240 


Val Pro Pro Val Ile His Ser Pro Asn Asp His Val Val Tyr Glu Lys 
                245                 250                 255     


Glu Pro Gly Glu Glu Leu Leu Ile Pro Cys Thr Val Tyr Phe Ser Phe 
            260                 265                 270         


Leu Met Asp Ser Arg Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys 
        275                 280                 285             


Pro Asp Asp Ile Thr Ile Asp Val Thr Ile Asn Glu Ser Ile Ser His 
    290                 295                 300                 


Ser Arg Thr Glu Asp Glu Thr Arg Thr Gln Ile Leu Ser Ile Lys Lys 
305                 310                 315                 320 


Val Thr Ser Glu Asp Leu Lys Arg Ser Tyr Val Cys His Ala Arg Ser 
                325                 330                 335     


Ala Lys Gly Glu Val Ala Lys Ala Ala Lys Val Lys Gln Lys Val Pro 
            340                 345                 350         


Ala Pro Arg Tyr Thr Val Glu Leu Ala Cys Gly Phe Gly Ala Thr Val 
        355                 360                 365             


Leu Leu Val Val Ile Leu Ile Val Val Tyr His Val Tyr Trp Leu Glu 
    370                 375                 380                 


Met Val Leu Phe Tyr Arg Ala His Phe Gly Thr Asp Glu Thr Ile Leu 
385                 390                 395                 400 


Asp Gly Lys Glu Tyr Asp Ile Tyr Val Ser Tyr Ala Arg Asn Ala Glu 
                405                 410                 415     


Glu Glu Glu Phe Val Leu Leu Thr Leu Arg Gly Val Leu Glu Asn Glu 
            420                 425                 430         


Phe Gly Tyr Lys Leu Cys Ile Phe Asp Arg Asp Ser Leu Pro Gly Gly 
        435                 440                 445             


Ile Val Thr Asp Glu Thr Leu Ser Phe Ile Gln Lys Ser Arg Arg Leu 
    450                 455                 460                 


Leu Val Val Leu Ser Pro Asn Tyr Val Leu Gln Gly Thr Gln Ala Leu 
465                 470                 475                 480 


Leu Glu Leu Lys Ala Gly Leu Glu Asn Met Ala Ser Arg Gly Asn Ile 
                485                 490                 495     


Asn Val Ile Leu Val Gln Tyr Lys Ala Val Lys Glu Thr Lys Val Lys 
            500                 505                 510         


Glu Leu Lys Arg Ala Lys Thr Val Leu Thr Val Ile Lys Trp Lys Gly 
        515                 520                 525             


Glu Lys Ser Lys Tyr Pro Gln Gly Arg Phe Trp Lys Gln Leu Gln Val 
    530                 535                 540                 


Ala Met Pro Val Lys Lys Ser Pro Arg Arg Ser Ser Ser Asp Glu Gln 
545                 550                 555                 560 


Gly Leu Ser Tyr Ser Ser Leu Lys Asn Val 
                565                 570 


<210>  6973
<211>  346
<212>  PRT
<213>  Homo Sapiens

<400>  6973

Met Thr Leu Leu Trp Cys Val Val Ser Leu Tyr Phe Tyr Gly Ile Leu 
1               5                   10                  15      


Gln Ser Asp Ala Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met 
            20                  25                  30          


Arg Gln Ile Gln Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro 
        35                  40                  45              


Leu Phe Glu His Phe Leu Lys Phe Asn Tyr Ser Thr Ala His Ser Ala 
    50                  55                  60                  


Gly Leu Thr Leu Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu 
65                  70                  75                  80  


Glu Pro Ile Asn Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys 
                85                  90                  95      


Asp Val Leu Trp Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Met Leu Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro 
        115                 120                 125             


Leu Glu Val Val Gln Lys Asp Ser Cys Phe Asn Ser Pro Met Lys Leu 
    130                 135                 140                 


Pro Val His Lys Leu Tyr Ile Glu Tyr Gly Ile Gln Arg Ile Thr Cys 
145                 150                 155                 160 


Pro Asn Val Asp Gly Tyr Phe Pro Ser Ser Val Lys Pro Thr Ile Thr 
                165                 170                 175     


Trp Tyr Met Gly Cys Tyr Lys Ile Gln Asn Phe Asn Asn Val Ile Pro 
            180                 185                 190         


Glu Gly Met Asn Leu Ser Phe Leu Ile Ala Leu Ile Ser Asn Asn Gly 
        195                 200                 205             


Asn Tyr Thr Cys Val Val Thr Tyr Pro Glu Asn Gly Arg Thr Phe His 
    210                 215                 220                 


Leu Thr Arg Thr Leu Thr Val Lys Val Val Gly Ser Pro Lys Asn Ala 
225                 230                 235                 240 


Val Pro Pro Val Ile His Ser Pro Asn Asp His Val Val Tyr Glu Lys 
                245                 250                 255     


Glu Pro Gly Glu Glu Leu Leu Ile Pro Cys Thr Val Tyr Phe Ser Phe 
            260                 265                 270         


Leu Met Asp Ser Arg Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys 
        275                 280                 285             


Pro Asp Asp Ile Thr Ile Asp Val Thr Ile Asn Glu Ser Ala Ser Ser 
    290                 295                 300                 


Lys Ile His Ser Gly Thr Gly Leu Trp Phe Trp Ser His Ser Pro Ala 
305                 310                 315                 320 


Ser Gly Asp Ser His Cys Cys Leu Pro Cys Leu Leu Ala Arg Asp Gly 
                325                 330                 335     


Pro Ile Leu Pro Gly Ser Phe Trp Asn Arg 
            340                 345     


<210>  6974
<211>  687
<212>  PRT
<213>  Homo Sapiens

<400>  6974

Met Thr Leu Leu Trp Cys Val Val Ser Leu Tyr Phe Tyr Gly Ile Leu 
1               5                   10                  15      


Gln Ser Asp Ala Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met 
            20                  25                  30          


Arg Gln Ile Gln Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro 
        35                  40                  45              


Leu Phe Glu His Phe Leu Lys Phe Asn Tyr Ser Thr Ala His Ser Ala 
    50                  55                  60                  


Gly Leu Thr Leu Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu 
65                  70                  75                  80  


Glu Pro Ile Asn Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys 
                85                  90                  95      


Asp Val Leu Trp Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Met Leu Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro 
        115                 120                 125             


Leu Glu Val Val Gln Lys Asp Ser Cys Phe Asn Ser Pro Met Lys Leu 
    130                 135                 140                 


Pro Val His Lys Leu Tyr Ile Glu Tyr Gly Ile Gln Arg Ile Thr Cys 
145                 150                 155                 160 


Pro Asn Val Asp Gly Tyr Phe Pro Ser Ser Val Lys Pro Thr Ile Thr 
                165                 170                 175     


Trp Tyr Met Gly Cys Tyr Lys Ile Gln Asn Phe Asn Asn Val Ile Pro 
            180                 185                 190         


Glu Gly Met Asn Leu Ser Phe Leu Ile Ala Leu Ile Ser Asn Asn Gly 
        195                 200                 205             


Asn Tyr Thr Cys Val Val Thr Tyr Pro Glu Asn Gly Arg Thr Phe His 
    210                 215                 220                 


Leu Thr Arg Thr Leu Thr Val Lys Val Val Gly Ser Pro Lys Asn Ala 
225                 230                 235                 240 


Val Pro Pro Val Ile His Ser Pro Asn Asp His Val Val Tyr Glu Lys 
                245                 250                 255     


Glu Pro Gly Glu Glu Leu Leu Ile Pro Cys Thr Val Tyr Phe Ser Phe 
            260                 265                 270         


Leu Met Asp Ser Arg Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys 
        275                 280                 285             


Pro Asp Asp Ile Thr Ile Asp Val Thr Ile Asn Glu Ser Ile Ser His 
    290                 295                 300                 


Ser Arg Thr Glu Asp Glu Thr Arg Thr Gln Ile Leu Ser Ile Lys Lys 
305                 310                 315                 320 


Val Thr Ser Glu Asp Leu Lys Arg Ser Tyr Val Cys His Ala Arg Ser 
                325                 330                 335     


Ala Lys Gly Glu Val Ala Lys Ala Ala Lys Val Lys Gln Lys Val Pro 
            340                 345                 350         


Ala Pro Arg Tyr Thr Val Glu Leu Ala Cys Gly Phe Gly Ala Thr Val 
        355                 360                 365             


Leu Leu Val Val Ile Leu Ile Val Val Tyr His Val Tyr Trp Leu Glu 
    370                 375                 380                 


Met Val Leu Phe Tyr Arg Ala His Phe Gly Thr Asp Glu Thr Ile Leu 
385                 390                 395                 400 


Asp Gly Lys Glu Tyr Asp Ile Tyr Val Ser Tyr Ala Arg Asn Ala Glu 
                405                 410                 415     


Glu Glu Glu Phe Val Leu Leu Thr Leu Arg Gly Val Leu Glu Asn Glu 
            420                 425                 430         


Phe Gly Tyr Lys Leu Cys Ile Phe Asp Arg Asp Ser Leu Pro Gly Gly 
        435                 440                 445             


Asn Thr Val Glu Ala Val Phe Asp Phe Ile Gln Arg Ser Arg Arg Met 
    450                 455                 460                 


Ile Val Val Leu Ser Pro Asp Tyr Val Thr Glu Lys Ser Ile Ser Met 
465                 470                 475                 480 


Leu Glu Phe Lys Leu Gly Val Met Cys Gln Asn Ser Ile Ala Thr Lys 
                485                 490                 495     


Leu Ile Val Val Glu Tyr Arg Pro Leu Glu His Pro His Pro Gly Ile 
            500                 505                 510         


Leu Gln Leu Lys Glu Ser Val Ser Phe Val Ser Trp Lys Gly Glu Lys 
        515                 520                 525             


Ser Lys His Ser Gly Ser Lys Phe Trp Lys Ala Leu Arg Leu Ala Leu 
    530                 535                 540                 


Pro Leu Arg Ser Leu Ser Ala Ser Ser Gly Trp Asn Glu Ser Cys Ser 
545                 550                 555                 560 


Ser Gln Ser Asp Ile Ser Leu Asp His Val Gln Arg Arg Arg Ser Arg 
                565                 570                 575     


Leu Lys Glu Pro Pro Glu Leu Gln Ser Ser Glu Arg Ala Ala Gly Ser 
            580                 585                 590         


Pro Pro Ala Pro Gly Thr Met Ser Lys His Arg Gly Lys Ser Ser Ala 
        595                 600                 605             


Thr Cys Arg Cys Cys Val Thr Tyr Cys Glu Gly Glu Asn His Leu Arg 
    610                 615                 620                 


Asn Lys Ser Arg Ala Glu Ile His Asn Gln Pro Gln Trp Glu Thr His 
625                 630                 635                 640 


Leu Cys Lys Pro Val Pro Gln Glu Ser Glu Thr Gln Trp Ile Gln Asn 
                645                 650                 655     


Gly Thr Arg Leu Glu Pro Pro Ala Pro Gln Ile Ser Ala Leu Ala Leu 
            660                 665                 670         


His His Phe Thr Asp Leu Ser Asn Asn Asn Asp Phe Tyr Ile Leu 
        675                 680                 685         


<210>  6975
<211>  570
<212>  PRT
<213>  Homo Sapiens

<400>  6975

Met Thr Leu Leu Trp Cys Val Val Ser Leu Tyr Phe Tyr Gly Ile Leu 
1               5                   10                  15      


Gln Ser Asp Ala Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met 
            20                  25                  30          


Arg Gln Ile Gln Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro 
        35                  40                  45              


Leu Phe Glu His Phe Leu Lys Phe Asn Tyr Ser Thr Ala His Ser Ala 
    50                  55                  60                  


Gly Leu Thr Leu Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu 
65                  70                  75                  80  


Glu Pro Ile Asn Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys 
                85                  90                  95      


Asp Val Leu Trp Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Met Leu Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro 
        115                 120                 125             


Leu Glu Val Val Gln Lys Asp Ser Cys Phe Asn Ser Pro Met Lys Leu 
    130                 135                 140                 


Pro Val His Lys Leu Tyr Ile Glu Tyr Gly Ile Gln Arg Ile Thr Cys 
145                 150                 155                 160 


Pro Asn Val Asp Gly Tyr Phe Pro Ser Ser Val Lys Pro Thr Ile Thr 
                165                 170                 175     


Trp Tyr Met Gly Cys Tyr Lys Ile Gln Asn Phe Asn Asn Val Ile Pro 
            180                 185                 190         


Glu Gly Met Asn Leu Ser Phe Leu Ile Ala Leu Ile Ser Asn Asn Gly 
        195                 200                 205             


Asn Tyr Thr Cys Val Val Thr Tyr Pro Glu Asn Gly Arg Thr Phe His 
    210                 215                 220                 


Leu Thr Arg Thr Leu Thr Val Lys Val Val Gly Ser Pro Lys Asn Ala 
225                 230                 235                 240 


Val Pro Pro Val Ile His Ser Pro Asn Asp His Val Val Tyr Glu Lys 
                245                 250                 255     


Glu Pro Gly Glu Glu Leu Leu Ile Pro Cys Thr Val Tyr Phe Ser Phe 
            260                 265                 270         


Leu Met Asp Ser Arg Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys 
        275                 280                 285             


Pro Asp Asp Ile Thr Ile Asp Val Thr Ile Asn Glu Ser Ile Ser His 
    290                 295                 300                 


Ser Arg Thr Glu Asp Glu Thr Arg Thr Gln Ile Leu Ser Ile Lys Lys 
305                 310                 315                 320 


Val Thr Ser Glu Asp Leu Lys Arg Ser Tyr Val Cys His Ala Arg Ser 
                325                 330                 335     


Ala Lys Gly Glu Val Ala Lys Ala Ala Lys Val Lys Gln Lys Val Pro 
            340                 345                 350         


Ala Pro Arg Tyr Thr Val Glu Leu Ala Cys Gly Phe Gly Ala Thr Val 
        355                 360                 365             


Leu Leu Val Val Ile Leu Ile Val Val Tyr His Val Tyr Trp Leu Glu 
    370                 375                 380                 


Met Val Leu Phe Tyr Arg Ala His Phe Gly Thr Asp Glu Thr Ile Leu 
385                 390                 395                 400 


Asp Gly Lys Glu Tyr Asp Ile Tyr Val Ser Tyr Ala Arg Asn Ala Glu 
                405                 410                 415     


Glu Glu Glu Phe Val Leu Leu Thr Leu Arg Gly Val Leu Glu Asn Glu 
            420                 425                 430         


Phe Gly Tyr Lys Leu Cys Ile Phe Asp Arg Asp Ser Leu Pro Gly Gly 
        435                 440                 445             


Ile Val Thr Asp Glu Thr Leu Ser Phe Ile Gln Lys Ser Arg Arg Leu 
    450                 455                 460                 


Leu Val Val Leu Ser Pro Asn Tyr Val Leu Gln Gly Thr Gln Ala Leu 
465                 470                 475                 480 


Leu Glu Leu Lys Ala Gly Leu Glu Asn Met Ala Ser Arg Gly Asn Ile 
                485                 490                 495     


Asn Val Ile Leu Val Gln Tyr Lys Ala Val Lys Glu Thr Lys Val Lys 
            500                 505                 510         


Glu Leu Lys Arg Ala Lys Thr Val Leu Thr Val Ile Lys Trp Lys Gly 
        515                 520                 525             


Glu Lys Ser Lys Tyr Pro Gln Gly Arg Phe Trp Lys Gln Leu Gln Val 
    530                 535                 540                 


Ala Met Pro Val Lys Lys Ser Pro Arg Arg Ser Ser Ser Asp Glu Gln 
545                 550                 555                 560 


Gly Leu Ser Tyr Ser Ser Leu Lys Asn Val 
                565                 570 


<210>  6976
<211>  687
<212>  PRT
<213>  Homo Sapiens

<400>  6976

Met Thr Leu Leu Trp Cys Val Val Ser Leu Tyr Phe Tyr Gly Ile Leu 
1               5                   10                  15      


Gln Ser Asp Ala Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met 
            20                  25                  30          


Arg Gln Ile Gln Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro 
        35                  40                  45              


Leu Phe Glu His Phe Leu Lys Phe Asn Tyr Ser Thr Ala His Ser Ala 
    50                  55                  60                  


Gly Leu Thr Leu Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu 
65                  70                  75                  80  


Glu Pro Ile Asn Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys 
                85                  90                  95      


Asp Val Leu Trp Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Met Leu Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro 
        115                 120                 125             


Leu Glu Val Val Gln Lys Asp Ser Cys Phe Asn Ser Pro Met Lys Leu 
    130                 135                 140                 


Pro Val His Lys Leu Tyr Ile Glu Tyr Gly Ile Gln Arg Ile Thr Cys 
145                 150                 155                 160 


Pro Asn Val Asp Gly Tyr Phe Pro Ser Ser Val Lys Pro Thr Ile Thr 
                165                 170                 175     


Trp Tyr Met Gly Cys Tyr Lys Ile Gln Asn Phe Asn Asn Val Ile Pro 
            180                 185                 190         


Glu Gly Met Asn Leu Ser Phe Leu Ile Ala Leu Ile Ser Asn Asn Gly 
        195                 200                 205             


Asn Tyr Thr Cys Val Val Thr Tyr Pro Glu Asn Gly Arg Thr Phe His 
    210                 215                 220                 


Leu Thr Arg Thr Leu Thr Val Lys Val Val Gly Ser Pro Lys Asn Ala 
225                 230                 235                 240 


Val Pro Pro Val Ile His Ser Pro Asn Asp His Val Val Tyr Glu Lys 
                245                 250                 255     


Glu Pro Gly Glu Glu Leu Leu Ile Pro Cys Thr Val Tyr Phe Ser Phe 
            260                 265                 270         


Leu Met Asp Ser Arg Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys 
        275                 280                 285             


Pro Asp Asp Ile Thr Ile Asp Val Thr Ile Asn Glu Ser Ile Ser His 
    290                 295                 300                 


Ser Arg Thr Glu Asp Glu Thr Arg Thr Gln Ile Leu Ser Ile Lys Lys 
305                 310                 315                 320 


Val Thr Ser Glu Asp Leu Lys Arg Ser Tyr Val Cys His Ala Arg Ser 
                325                 330                 335     


Ala Lys Gly Glu Val Ala Lys Ala Ala Lys Val Lys Gln Lys Val Pro 
            340                 345                 350         


Ala Pro Arg Tyr Thr Val Glu Leu Ala Cys Gly Phe Gly Ala Thr Val 
        355                 360                 365             


Leu Leu Val Val Ile Leu Ile Val Val Tyr His Val Tyr Trp Leu Glu 
    370                 375                 380                 


Met Val Leu Phe Tyr Arg Ala His Phe Gly Thr Asp Glu Thr Ile Leu 
385                 390                 395                 400 


Asp Gly Lys Glu Tyr Asp Ile Tyr Val Ser Tyr Ala Arg Asn Ala Glu 
                405                 410                 415     


Glu Glu Glu Phe Val Leu Leu Thr Leu Arg Gly Val Leu Glu Asn Glu 
            420                 425                 430         


Phe Gly Tyr Lys Leu Cys Ile Phe Asp Arg Asp Ser Leu Pro Gly Gly 
        435                 440                 445             


Asn Thr Val Glu Ala Val Phe Asp Phe Ile Gln Arg Ser Arg Arg Met 
    450                 455                 460                 


Ile Val Val Leu Ser Pro Asp Tyr Val Thr Glu Lys Ser Ile Ser Met 
465                 470                 475                 480 


Leu Glu Phe Lys Leu Gly Val Met Cys Gln Asn Ser Ile Ala Thr Lys 
                485                 490                 495     


Leu Ile Val Val Glu Tyr Arg Pro Leu Glu His Pro His Pro Gly Ile 
            500                 505                 510         


Leu Gln Leu Lys Glu Ser Val Ser Phe Val Ser Trp Lys Gly Glu Lys 
        515                 520                 525             


Ser Lys His Ser Gly Ser Lys Phe Trp Lys Ala Leu Arg Leu Ala Leu 
    530                 535                 540                 


Pro Leu Arg Ser Leu Ser Ala Ser Ser Gly Trp Asn Glu Ser Cys Ser 
545                 550                 555                 560 


Ser Gln Ser Asp Ile Ser Leu Asp His Val Gln Arg Arg Arg Ser Arg 
                565                 570                 575     


Leu Lys Glu Pro Pro Glu Leu Gln Ser Ser Glu Arg Ala Ala Gly Ser 
            580                 585                 590         


Pro Pro Ala Pro Gly Thr Met Ser Lys His Arg Gly Lys Ser Ser Ala 
        595                 600                 605             


Thr Cys Arg Cys Cys Val Thr Tyr Cys Glu Gly Glu Asn His Leu Arg 
    610                 615                 620                 


Asn Lys Ser Arg Ala Glu Ile His Asn Gln Pro Gln Trp Glu Thr His 
625                 630                 635                 640 


Leu Cys Lys Pro Val Pro Gln Glu Ser Glu Thr Gln Trp Ile Gln Asn 
                645                 650                 655     


Gly Thr Arg Leu Glu Pro Pro Ala Pro Gln Ile Ser Ala Leu Ala Leu 
            660                 665                 670         


His His Phe Thr Asp Leu Ser Asn Asn Asn Asp Phe Tyr Ile Leu 
        675                 680                 685         


<210>  6977
<211>  356
<212>  PRT
<213>  Homo Sapiens

<400>  6977

Met Thr Leu Leu Trp Cys Val Val Ser Leu Tyr Phe Tyr Gly Ile Leu 
1               5                   10                  15      


Gln Ser Asp Ala Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met 
            20                  25                  30          


Arg Gln Ile Gln Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro 
        35                  40                  45              


Leu Phe Glu His Phe Leu Lys Phe Asn Tyr Ser Thr Ala His Ser Ala 
    50                  55                  60                  


Gly Leu Thr Leu Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu 
65                  70                  75                  80  


Glu Pro Ile Asn Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys 
                85                  90                  95      


Asp Val Leu Trp Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Met Leu Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro 
        115                 120                 125             


Leu Glu Val Val Gln Lys Asp Ser Cys Phe Asn Ser Pro Met Lys Leu 
    130                 135                 140                 


Pro Val His Lys Leu Tyr Ile Glu Tyr Gly Ile Gln Arg Ile Thr Cys 
145                 150                 155                 160 


Pro Asn Val Asp Gly Tyr Phe Pro Ser Ser Val Lys Pro Thr Ile Thr 
                165                 170                 175     


Trp Tyr Met Gly Cys Tyr Lys Ile Gln Asn Phe Asn Asn Val Ile Pro 
            180                 185                 190         


Glu Gly Met Asn Leu Ser Phe Leu Ile Ala Leu Ile Ser Asn Asn Gly 
        195                 200                 205             


Asn Tyr Thr Cys Val Val Thr Tyr Pro Glu Asn Gly Arg Thr Phe His 
    210                 215                 220                 


Leu Thr Arg Thr Leu Thr Val Lys Val Val Gly Ser Pro Lys Asn Ala 
225                 230                 235                 240 


Val Pro Pro Val Ile His Ser Pro Asn Asp His Val Val Tyr Glu Lys 
                245                 250                 255     


Glu Pro Gly Glu Glu Leu Leu Ile Pro Cys Thr Val Tyr Phe Ser Phe 
            260                 265                 270         


Leu Met Asp Ser Arg Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys 
        275                 280                 285             


Pro Asp Asp Ile Thr Ile Asp Val Thr Ile Asn Glu Ser Ile Ser His 
    290                 295                 300                 


Ser Arg Thr Glu Asp Glu Thr Arg Thr Gln Ile Leu Ser Ile Lys Lys 
305                 310                 315                 320 


Val Thr Ser Glu Asp Leu Lys Arg Ser Tyr Val Cys His Ala Arg Ser 
                325                 330                 335     


Ala Lys Gly Glu Val Ala Lys Ala Ala Lys Val Lys Gln Lys Gly Asn 
            340                 345                 350         


Arg Cys Gly Gln 
        355     


<210>  6978
<211>  356
<212>  PRT
<213>  Homo Sapiens

<400>  6978

Met Thr Leu Leu Trp Cys Val Val Ser Leu Tyr Phe Tyr Gly Ile Leu 
1               5                   10                  15      


Gln Ser Asp Ala Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met 
            20                  25                  30          


Arg Gln Ile Gln Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro 
        35                  40                  45              


Leu Phe Glu His Phe Leu Lys Phe Asn Tyr Ser Thr Ala His Ser Ala 
    50                  55                  60                  


Gly Leu Thr Leu Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu 
65                  70                  75                  80  


Glu Pro Ile Asn Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys 
                85                  90                  95      


Asp Val Leu Trp Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Met Leu Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro 
        115                 120                 125             


Leu Glu Val Val Gln Lys Asp Ser Cys Phe Asn Ser Pro Met Lys Leu 
    130                 135                 140                 


Pro Val His Lys Leu Tyr Ile Glu Tyr Gly Ile Gln Arg Ile Thr Cys 
145                 150                 155                 160 


Pro Asn Val Asp Gly Tyr Phe Pro Ser Ser Val Lys Pro Thr Ile Thr 
                165                 170                 175     


Trp Tyr Met Gly Cys Tyr Lys Ile Gln Asn Phe Asn Asn Val Ile Pro 
            180                 185                 190         


Glu Gly Met Asn Leu Ser Phe Leu Ile Ala Leu Ile Ser Asn Asn Gly 
        195                 200                 205             


Asn Tyr Thr Cys Val Val Thr Tyr Pro Glu Asn Gly Arg Thr Phe His 
    210                 215                 220                 


Leu Thr Arg Thr Leu Thr Val Lys Val Val Gly Ser Pro Lys Asn Ala 
225                 230                 235                 240 


Val Pro Pro Val Ile His Ser Pro Asn Asp His Val Val Tyr Glu Lys 
                245                 250                 255     


Glu Pro Gly Glu Glu Leu Leu Ile Pro Cys Thr Val Tyr Phe Ser Phe 
            260                 265                 270         


Leu Met Asp Ser Arg Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys 
        275                 280                 285             


Pro Asp Asp Ile Thr Ile Asp Val Thr Ile Asn Glu Ser Ile Ser His 
    290                 295                 300                 


Ser Arg Thr Glu Asp Glu Thr Arg Thr Gln Ile Leu Ser Ile Lys Lys 
305                 310                 315                 320 


Val Thr Ser Glu Asp Leu Lys Arg Ser Tyr Val Cys His Ala Arg Ser 
                325                 330                 335     


Ala Lys Gly Glu Val Ala Lys Ala Ala Lys Val Lys Gln Lys Gly Asn 
            340                 345                 350         


Arg Cys Gly Gln 
        355     


<210>  6979
<211>  346
<212>  PRT
<213>  Homo Sapiens

<400>  6979

Met Thr Leu Leu Trp Cys Val Val Ser Leu Tyr Phe Tyr Gly Ile Leu 
1               5                   10                  15      


Gln Ser Asp Ala Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met 
            20                  25                  30          


Arg Gln Ile Gln Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro 
        35                  40                  45              


Leu Phe Glu His Phe Leu Lys Phe Asn Tyr Ser Thr Ala His Ser Ala 
    50                  55                  60                  


Gly Leu Thr Leu Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu 
65                  70                  75                  80  


Glu Pro Ile Asn Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys 
                85                  90                  95      


Asp Val Leu Trp Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Met Leu Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro 
        115                 120                 125             


Leu Glu Val Val Gln Lys Asp Ser Cys Phe Asn Ser Pro Met Lys Leu 
    130                 135                 140                 


Pro Val His Lys Leu Tyr Ile Glu Tyr Gly Ile Gln Arg Ile Thr Cys 
145                 150                 155                 160 


Pro Asn Val Asp Gly Tyr Phe Pro Ser Ser Val Lys Pro Thr Ile Thr 
                165                 170                 175     


Trp Tyr Met Gly Cys Tyr Lys Ile Gln Asn Phe Asn Asn Val Ile Pro 
            180                 185                 190         


Glu Gly Met Asn Leu Ser Phe Leu Ile Ala Leu Ile Ser Asn Asn Gly 
        195                 200                 205             


Asn Tyr Thr Cys Val Val Thr Tyr Pro Glu Asn Gly Arg Thr Phe His 
    210                 215                 220                 


Leu Thr Arg Thr Leu Thr Val Lys Val Val Gly Ser Pro Lys Asn Ala 
225                 230                 235                 240 


Val Pro Pro Val Ile His Ser Pro Asn Asp His Val Val Tyr Glu Lys 
                245                 250                 255     


Glu Pro Gly Glu Glu Leu Leu Ile Pro Cys Thr Val Tyr Phe Ser Phe 
            260                 265                 270         


Leu Met Asp Ser Arg Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys 
        275                 280                 285             


Pro Asp Asp Ile Thr Ile Asp Val Thr Ile Asn Glu Ser Ala Ser Ser 
    290                 295                 300                 


Lys Ile His Ser Gly Thr Gly Leu Trp Phe Trp Ser His Ser Pro Ala 
305                 310                 315                 320 


Ser Gly Asp Ser His Cys Cys Leu Pro Cys Leu Leu Ala Arg Asp Gly 
                325                 330                 335     


Pro Ile Leu Pro Gly Ser Phe Trp Asn Arg 
            340                 345     


<210>  6980
<211>  570
<212>  PRT
<213>  Homo Sapiens

<400>  6980

Met Thr Leu Leu Trp Cys Val Val Ser Leu Tyr Phe Tyr Gly Ile Leu 
1               5                   10                  15      


Gln Ser Asp Ala Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met 
            20                  25                  30          


Arg Gln Ile Gln Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro 
        35                  40                  45              


Leu Phe Glu His Phe Leu Lys Phe Asn Tyr Ser Thr Ala His Ser Ala 
    50                  55                  60                  


Gly Leu Thr Leu Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu 
65                  70                  75                  80  


Glu Pro Ile Asn Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys 
                85                  90                  95      


Asp Val Leu Trp Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Met Leu Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro 
        115                 120                 125             


Leu Glu Val Val Gln Lys Asp Ser Cys Phe Asn Ser Pro Met Lys Leu 
    130                 135                 140                 


Pro Val His Lys Leu Tyr Ile Glu Tyr Gly Ile Gln Arg Ile Thr Cys 
145                 150                 155                 160 


Pro Asn Val Asp Gly Tyr Phe Pro Ser Ser Val Lys Pro Thr Ile Thr 
                165                 170                 175     


Trp Tyr Met Gly Cys Tyr Lys Ile Gln Asn Phe Asn Asn Val Ile Pro 
            180                 185                 190         


Glu Gly Met Asn Leu Ser Phe Leu Ile Ala Leu Ile Ser Asn Asn Gly 
        195                 200                 205             


Asn Tyr Thr Cys Val Val Thr Tyr Pro Glu Asn Gly Arg Thr Phe His 
    210                 215                 220                 


Leu Thr Arg Thr Leu Thr Val Lys Val Val Gly Ser Pro Lys Asn Ala 
225                 230                 235                 240 


Val Pro Pro Val Ile His Ser Pro Asn Asp His Val Val Tyr Glu Lys 
                245                 250                 255     


Glu Pro Gly Glu Glu Leu Leu Ile Pro Cys Thr Val Tyr Phe Ser Phe 
            260                 265                 270         


Leu Met Asp Ser Arg Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys 
        275                 280                 285             


Pro Asp Asp Ile Thr Ile Asp Val Thr Ile Asn Glu Ser Ile Ser His 
    290                 295                 300                 


Ser Arg Thr Glu Asp Glu Thr Arg Thr Gln Ile Leu Ser Ile Lys Lys 
305                 310                 315                 320 


Val Thr Ser Glu Asp Leu Lys Arg Ser Tyr Val Cys His Ala Arg Ser 
                325                 330                 335     


Ala Lys Gly Glu Val Ala Lys Ala Ala Lys Val Lys Gln Lys Val Pro 
            340                 345                 350         


Ala Pro Arg Tyr Thr Val Glu Leu Ala Cys Gly Phe Gly Ala Thr Val 
        355                 360                 365             


Leu Leu Val Val Ile Leu Ile Val Val Tyr His Val Tyr Trp Leu Glu 
    370                 375                 380                 


Met Val Leu Phe Tyr Arg Ala His Phe Gly Thr Asp Glu Thr Ile Leu 
385                 390                 395                 400 


Asp Gly Lys Glu Tyr Asp Ile Tyr Val Ser Tyr Ala Arg Asn Ala Glu 
                405                 410                 415     


Glu Glu Glu Phe Val Leu Leu Thr Leu Arg Gly Val Leu Glu Asn Glu 
            420                 425                 430         


Phe Gly Tyr Lys Leu Cys Ile Phe Asp Arg Asp Ser Leu Pro Gly Gly 
        435                 440                 445             


Ile Val Thr Asp Glu Thr Leu Ser Phe Ile Gln Lys Ser Arg Arg Leu 
    450                 455                 460                 


Leu Val Val Leu Ser Pro Asn Tyr Val Leu Gln Gly Thr Gln Ala Leu 
465                 470                 475                 480 


Leu Glu Leu Lys Ala Gly Leu Glu Asn Met Ala Ser Arg Gly Asn Ile 
                485                 490                 495     


Asn Val Ile Leu Val Gln Tyr Lys Ala Val Lys Glu Thr Lys Val Lys 
            500                 505                 510         


Glu Leu Lys Arg Ala Lys Thr Val Leu Thr Val Ile Lys Trp Lys Gly 
        515                 520                 525             


Glu Lys Ser Lys Tyr Pro Gln Gly Arg Phe Trp Lys Gln Leu Gln Val 
    530                 535                 540                 


Ala Met Pro Val Lys Lys Ser Pro Arg Arg Ser Ser Ser Asp Glu Gln 
545                 550                 555                 560 


Gly Leu Ser Tyr Ser Ser Leu Lys Asn Val 
                565                 570 


<210>  6981
<211>  570
<212>  PRT
<213>  Homo Sapiens

<400>  6981

Met Thr Leu Leu Trp Cys Val Val Ser Leu Tyr Phe Tyr Gly Ile Leu 
1               5                   10                  15      


Gln Ser Asp Ala Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met 
            20                  25                  30          


Arg Gln Ile Gln Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro 
        35                  40                  45              


Leu Phe Glu His Phe Leu Lys Phe Asn Tyr Ser Thr Ala His Ser Ala 
    50                  55                  60                  


Gly Leu Thr Leu Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu 
65                  70                  75                  80  


Glu Pro Ile Asn Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys 
                85                  90                  95      


Asp Val Leu Trp Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Met Leu Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro 
        115                 120                 125             


Leu Glu Val Val Gln Lys Asp Ser Cys Phe Asn Ser Pro Met Lys Leu 
    130                 135                 140                 


Pro Val His Lys Leu Tyr Ile Glu Tyr Gly Ile Gln Arg Ile Thr Cys 
145                 150                 155                 160 


Pro Asn Val Asp Gly Tyr Phe Pro Ser Ser Val Lys Pro Thr Ile Thr 
                165                 170                 175     


Trp Tyr Met Gly Cys Tyr Lys Ile Gln Asn Phe Asn Asn Val Ile Pro 
            180                 185                 190         


Glu Gly Met Asn Leu Ser Phe Leu Ile Ala Leu Ile Ser Asn Asn Gly 
        195                 200                 205             


Asn Tyr Thr Cys Val Val Thr Tyr Pro Glu Asn Gly Arg Thr Phe His 
    210                 215                 220                 


Leu Thr Arg Thr Leu Thr Val Lys Val Val Gly Ser Pro Lys Asn Ala 
225                 230                 235                 240 


Val Pro Pro Val Ile His Ser Pro Asn Asp His Val Val Tyr Glu Lys 
                245                 250                 255     


Glu Pro Gly Glu Glu Leu Leu Ile Pro Cys Thr Val Tyr Phe Ser Phe 
            260                 265                 270         


Leu Met Asp Ser Arg Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys 
        275                 280                 285             


Pro Asp Asp Ile Thr Ile Asp Val Thr Ile Asn Glu Ser Ile Ser His 
    290                 295                 300                 


Ser Arg Thr Glu Asp Glu Thr Arg Thr Gln Ile Leu Ser Ile Lys Lys 
305                 310                 315                 320 


Val Thr Ser Glu Asp Leu Lys Arg Ser Tyr Val Cys His Ala Arg Ser 
                325                 330                 335     


Ala Lys Gly Glu Val Ala Lys Ala Ala Lys Val Lys Gln Lys Val Pro 
            340                 345                 350         


Ala Pro Arg Tyr Thr Val Glu Leu Ala Cys Gly Phe Gly Ala Thr Val 
        355                 360                 365             


Leu Leu Val Val Ile Leu Ile Val Val Tyr His Val Tyr Trp Leu Glu 
    370                 375                 380                 


Met Val Leu Phe Tyr Arg Ala His Phe Gly Thr Asp Glu Thr Ile Leu 
385                 390                 395                 400 


Asp Gly Lys Glu Tyr Asp Ile Tyr Val Ser Tyr Ala Arg Asn Ala Glu 
                405                 410                 415     


Glu Glu Glu Phe Val Leu Leu Thr Leu Arg Gly Val Leu Glu Asn Glu 
            420                 425                 430         


Phe Gly Tyr Lys Leu Cys Ile Phe Asp Arg Asp Ser Leu Pro Gly Gly 
        435                 440                 445             


Ile Val Thr Asp Glu Thr Leu Ser Phe Ile Gln Lys Ser Arg Arg Leu 
    450                 455                 460                 


Leu Val Val Leu Ser Pro Asn Tyr Val Leu Gln Gly Thr Gln Ala Leu 
465                 470                 475                 480 


Leu Glu Leu Lys Ala Gly Leu Glu Asn Met Ala Ser Arg Gly Asn Ile 
                485                 490                 495     


Asn Val Ile Leu Val Gln Tyr Lys Ala Val Lys Glu Thr Lys Val Lys 
            500                 505                 510         


Glu Leu Lys Arg Ala Lys Thr Val Leu Thr Val Ile Lys Trp Lys Gly 
        515                 520                 525             


Glu Lys Ser Lys Tyr Pro Gln Gly Arg Phe Trp Lys Gln Leu Gln Val 
    530                 535                 540                 


Ala Met Pro Val Lys Lys Ser Pro Arg Arg Ser Ser Ser Asp Glu Gln 
545                 550                 555                 560 


Gly Leu Ser Tyr Ser Ser Leu Lys Asn Val 
                565                 570 


<210>  6982
<211>  193
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  6982

Xaa Phe Ile His Ile Gly Thr Ser Lys His Ile Glu Val Lys Thr Gln 
1               5                   10                  15      


Gly Cys Tyr Lys Ile Gln Asn Phe Asn Asn Val Ile Pro Glu Gly Met 
            20                  25                  30          


Asn Leu Ser Phe Leu Ile Ala Leu Ile Ser Asn Asn Gly Asn Tyr Thr 
        35                  40                  45              


Cys Val Val Thr Tyr Pro Glu Asn Gly Arg Thr Phe His Leu Thr Arg 
    50                  55                  60                  


Thr Leu Thr Val Lys Val Val Gly Ser Pro Lys Asn Ala Val Pro Pro 
65                  70                  75                  80  


Val Ile His Ser Pro Asn Asp His Val Val Tyr Glu Lys Glu Pro Gly 
                85                  90                  95      


Glu Glu Leu Leu Ile Pro Cys Thr Val Tyr Phe Ser Phe Leu Met Asp 
            100                 105                 110         


Ser Arg Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys Pro Asp Asp 
        115                 120                 125             


Ile Thr Ile Asp Val Thr Ile Asn Glu Ser Ile Ser His Ser Arg Thr 
    130                 135                 140                 


Glu Asp Glu Thr Arg Thr Gln Ile Leu Ser Ile Lys Lys Val Thr Ser 
145                 150                 155                 160 


Glu Asp Leu Lys Arg Ser Tyr Val Cys His Ala Arg Ser Ala Lys Gly 
                165                 170                 175     


Glu Val Ala Lys Ala Ala Lys Val Lys Gln Lys Gly Asn Arg Cys Gly 
            180                 185                 190         


Gln 
    


<210>  6983
<211>  38
<212>  PRT
<213>  Homo Sapiens

<400>  6983

Met Gly Phe Trp Ile Leu Ala Ile Leu Thr Ile Leu Met Tyr Ser Thr 
1               5                   10                  15      


Ala Ala Lys Phe Ser Lys Gln Ser Trp Gly Leu Glu Asn Glu Ala Leu 
            20                  25                  30          


Ile Val Arg Cys Pro Arg 
        35              


<210>  6984
<211>  556
<212>  PRT
<213>  Homo Sapiens

<400>  6984

Met Gly Phe Trp Ile Leu Ala Ile Leu Thr Ile Leu Met Tyr Ser Thr 
1               5                   10                  15      


Ala Ala Lys Phe Ser Lys Gln Ser Trp Gly Leu Glu Asn Glu Ala Leu 
            20                  25                  30          


Ile Val Arg Cys Pro Arg Gln Gly Lys Pro Ser Tyr Thr Val Asp Trp 
        35                  40                  45              


Tyr Tyr Ser Gln Thr Asn Lys Ser Ile Pro Thr Gln Glu Arg Asn Arg 
    50                  55                  60                  


Val Phe Ala Ser Gly Gln Leu Leu Lys Phe Leu Pro Ala Ala Val Ala 
65                  70                  75                  80  


Asp Ser Gly Ile Tyr Thr Cys Ile Val Arg Ser Pro Thr Phe Asn Arg 
                85                  90                  95      


Thr Gly Tyr Ala Asn Val Thr Ile Tyr Lys Lys Gln Ser Asp Cys Asn 
            100                 105                 110         


Val Pro Asp Tyr Leu Met Tyr Ser Thr Val Ser Gly Ser Glu Lys Asn 
        115                 120                 125             


Ser Lys Ile Tyr Cys Pro Thr Ile Asp Leu Tyr Asn Trp Thr Ala Pro 
    130                 135                 140                 


Leu Glu Trp Phe Lys Asn Cys Gln Ala Leu Gln Gly Ser Arg Tyr Arg 
145                 150                 155                 160 


Ala His Lys Ser Phe Leu Val Ile Asp Asn Val Met Thr Glu Asp Ala 
                165                 170                 175     


Gly Asp Tyr Thr Cys Lys Phe Ile His Asn Glu Asn Gly Ala Asn Tyr 
            180                 185                 190         


Ser Val Thr Ala Thr Arg Ser Phe Thr Val Lys Asp Glu Gln Gly Phe 
        195                 200                 205             


Ser Leu Phe Pro Val Ile Gly Ala Pro Ala Gln Asn Glu Ile Lys Glu 
    210                 215                 220                 


Val Glu Ile Gly Lys Asn Ala Asn Leu Thr Cys Ser Ala Cys Phe Gly 
225                 230                 235                 240 


Lys Gly Thr Gln Phe Leu Ala Ala Val Leu Trp Gln Leu Asn Gly Thr 
                245                 250                 255     


Lys Ile Thr Asp Phe Gly Glu Pro Arg Ile Gln Gln Glu Glu Gly Gln 
            260                 265                 270         


Asn Gln Ser Phe Ser Asn Gly Leu Ala Cys Leu Asp Met Val Leu Arg 
        275                 280                 285             


Ile Ala Asp Val Lys Glu Glu Asp Leu Leu Leu Gln Tyr Asp Cys Leu 
    290                 295                 300                 


Ala Leu Asn Leu His Gly Leu Arg Arg His Thr Val Arg Leu Ser Arg 
305                 310                 315                 320 


Lys Asn Pro Ile Asp His His Ser Ile Tyr Cys Ile Ile Ala Val Cys 
                325                 330                 335     


Ser Val Phe Leu Met Leu Ile Asn Val Leu Val Ile Ile Leu Lys Met 
            340                 345                 350         


Phe Trp Ile Glu Ala Thr Leu Leu Trp Arg Asp Ile Ala Lys Pro Tyr 
        355                 360                 365             


Lys Thr Arg Asn Asp Gly Lys Leu Tyr Asp Ala Tyr Val Val Tyr Pro 
    370                 375                 380                 


Arg Asn Tyr Lys Ser Ser Thr Asp Gly Ala Ser Arg Val Glu His Phe 
385                 390                 395                 400 


Val His Gln Ile Leu Pro Asp Val Leu Glu Asn Lys Cys Gly Tyr Thr 
                405                 410                 415     


Leu Cys Ile Tyr Gly Arg Asp Met Leu Pro Gly Glu Asp Val Val Thr 
            420                 425                 430         


Ala Val Glu Thr Asn Ile Arg Lys Ser Arg Arg His Ile Phe Ile Leu 
        435                 440                 445             


Thr Pro Gln Ile Thr His Asn Lys Glu Phe Ala Tyr Glu Gln Glu Val 
    450                 455                 460                 


Ala Leu His Cys Ala Leu Ile Gln Asn Asp Ala Lys Val Ile Leu Ile 
465                 470                 475                 480 


Glu Met Glu Ala Leu Ser Glu Leu Asp Met Leu Gln Ala Glu Ala Leu 
                485                 490                 495     


Gln Asp Ser Leu Gln His Leu Met Lys Val Gln Gly Thr Ile Lys Trp 
            500                 505                 510         


Arg Glu Asp His Ile Ala Asn Lys Arg Ser Leu Asn Ser Lys Phe Trp 
        515                 520                 525             


Lys His Val Arg Tyr Gln Met Pro Val Pro Ser Lys Ile Pro Arg Lys 
    530                 535                 540                 


Ala Ser Ser Leu Thr Pro Leu Ala Ala Gln Lys Gln 
545                 550                 555     


<210>  6985
<211>  328
<212>  PRT
<213>  Homo Sapiens

<400>  6985

Met Gly Phe Trp Ile Leu Ala Ile Leu Thr Ile Leu Met Tyr Ser Thr 
1               5                   10                  15      


Ala Ala Lys Phe Ser Lys Gln Ser Trp Gly Leu Glu Asn Glu Ala Leu 
            20                  25                  30          


Ile Val Arg Cys Pro Arg Gln Gly Lys Pro Ser Tyr Thr Val Asp Trp 
        35                  40                  45              


Tyr Tyr Ser Gln Thr Asn Lys Ser Ile Pro Thr Gln Glu Arg Asn Arg 
    50                  55                  60                  


Val Phe Ala Ser Gly Gln Leu Leu Lys Phe Leu Pro Ala Ala Val Ala 
65                  70                  75                  80  


Asp Ser Gly Ile Tyr Thr Cys Ile Val Arg Ser Pro Thr Phe Asn Arg 
                85                  90                  95      


Thr Gly Tyr Ala Asn Val Thr Ile Tyr Lys Lys Gln Ser Asp Cys Asn 
            100                 105                 110         


Val Pro Asp Tyr Leu Met Tyr Ser Thr Val Ser Gly Ser Glu Lys Asn 
        115                 120                 125             


Ser Lys Ile Tyr Cys Pro Thr Ile Asp Leu Tyr Asn Trp Thr Ala Pro 
    130                 135                 140                 


Leu Glu Trp Phe Lys Asn Cys Gln Ala Leu Gln Gly Ser Arg Tyr Arg 
145                 150                 155                 160 


Ala His Lys Ser Phe Leu Val Ile Asp Asn Val Met Thr Glu Asp Ala 
                165                 170                 175     


Gly Asp Tyr Thr Cys Lys Phe Ile His Asn Glu Asn Gly Ala Asn Tyr 
            180                 185                 190         


Ser Val Thr Ala Thr Arg Ser Phe Thr Val Lys Asp Glu Gln Gly Phe 
        195                 200                 205             


Ser Leu Phe Pro Val Ile Gly Ala Pro Ala Gln Asn Glu Ile Lys Glu 
    210                 215                 220                 


Val Glu Ile Gly Lys Asn Ala Asn Leu Thr Cys Ser Ala Cys Phe Gly 
225                 230                 235                 240 


Lys Gly Thr Gln Phe Leu Ala Ala Val Leu Trp Gln Leu Asn Gly Thr 
                245                 250                 255     


Lys Ile Thr Asp Phe Gly Glu Pro Arg Ile Gln Gln Glu Glu Gly Gln 
            260                 265                 270         


Asn Gln Ser Phe Ser Asn Gly Leu Ala Cys Leu Asp Met Val Leu Arg 
        275                 280                 285             


Ile Ala Asp Val Lys Glu Glu Asp Leu Leu Leu Gln Tyr Asp Cys Leu 
    290                 295                 300                 


Ala Leu Asn Leu His Gly Leu Arg Arg His Thr Val Arg Leu Ser Arg 
305                 310                 315                 320 


Lys Asn Pro Ser Lys Glu Cys Phe 
                325             


<210>  6986
<211>  314
<212>  PRT
<213>  Homo Sapiens

<400>  6986

Met Gly Phe Trp Ile Leu Ala Ile Leu Thr Ile Leu Met Tyr Ser Thr 
1               5                   10                  15      


Ala Ala Lys Phe Ser Lys Gln Ser Trp Gly Leu Glu Asn Glu Ala Leu 
            20                  25                  30          


Ile Val Arg Cys Pro Arg Gln Gly Lys Pro Ser Tyr Thr Val Asp Trp 
        35                  40                  45              


Tyr Tyr Ser Gln Thr Asn Lys Ser Ile Pro Thr Gln Glu Arg Asn Arg 
    50                  55                  60                  


Val Phe Ala Ser Gly Gln Leu Leu Lys Phe Leu Pro Ala Ala Val Ala 
65                  70                  75                  80  


Asp Ser Gly Ile Tyr Thr Cys Ile Val Arg Ser Pro Thr Phe Asn Arg 
                85                  90                  95      


Thr Gly Tyr Ala Asn Val Thr Ile Tyr Lys Lys Gln Ser Asp Cys Asn 
            100                 105                 110         


Val Pro Asp Tyr Leu Met Tyr Ser Thr Val Ser Gly Ser Glu Lys Asn 
        115                 120                 125             


Ser Lys Ile Tyr Cys Pro Thr Ile Asp Leu Tyr Asn Trp Thr Ala Pro 
    130                 135                 140                 


Leu Glu Trp Phe Lys Asn Cys Gln Ala Leu Gln Gly Ser Arg Tyr Arg 
145                 150                 155                 160 


Ala His Lys Ser Phe Leu Val Ile Asp Asn Val Met Thr Glu Asp Ala 
                165                 170                 175     


Gly Asp Tyr Thr Cys Lys Phe Ile His Asn Glu Asn Gly Ala Asn Tyr 
            180                 185                 190         


Ser Val Thr Ala Thr Arg Ser Phe Thr Val Lys Asp Glu Gln Gly Phe 
        195                 200                 205             


Ser Leu Phe Pro Val Ile Gly Ala Pro Ala Gln Asn Glu Ile Lys Glu 
    210                 215                 220                 


Val Glu Ile Gly Thr Gln Phe Leu Ala Ala Val Leu Trp Gln Leu Asn 
225                 230                 235                 240 


Gly Thr Lys Ile Thr Asp Phe Gly Glu Pro Arg Ile Gln Gln Glu Glu 
                245                 250                 255     


Gly Gln Asn Gln Ser Phe Ser Asn Gly Leu Ala Cys Leu Asp Met Val 
            260                 265                 270         


Leu Arg Ile Ala Asp Val Lys Glu Glu Asp Leu Leu Leu Gln Tyr Asp 
        275                 280                 285             


Cys Leu Ala Leu Asn Leu His Gly Leu Arg Arg His Thr Val Arg Leu 
    290                 295                 300                 


Ser Arg Lys Asn Pro Ser Lys Glu Cys Phe 
305                 310                 


<210>  6987
<211>  259
<212>  PRT
<213>  Homo Sapiens

<400>  6987

Met Gly Phe Trp Ile Leu Ala Ile Leu Thr Ile Leu Met Tyr Ser Thr 
1               5                   10                  15      


Ala Ala Lys Phe Ser Lys Gln Ser Trp Gly Leu Glu Asn Glu Ala Leu 
            20                  25                  30          


Ile Val Arg Cys Pro Arg Gln Gly Lys Pro Ser Tyr Thr Val Asp Trp 
        35                  40                  45              


Tyr Tyr Ser Gln Thr Asn Lys Ser Ile Pro Thr Gln Glu Arg Asn Arg 
    50                  55                  60                  


Val Phe Ala Ser Gly Gln Leu Leu Lys Phe Leu Pro Ala Ala Val Ala 
65                  70                  75                  80  


Asp Ser Gly Ile Tyr Thr Cys Ile Val Arg Ser Pro Thr Phe Asn Arg 
                85                  90                  95      


Thr Gly Tyr Ala Asn Val Thr Ile Tyr Lys Lys Gln Ser Asp Cys Asn 
            100                 105                 110         


Val Pro Asp Tyr Leu Met Tyr Ser Thr Val Ser Gly Ser Glu Lys Asn 
        115                 120                 125             


Ser Lys Ile Tyr Cys Pro Thr Ile Asp Leu Tyr Asn Trp Thr Ala Pro 
    130                 135                 140                 


Leu Glu Trp Phe Lys Asn Cys Gln Ala Leu Gln Gly Ser Arg Tyr Arg 
145                 150                 155                 160 


Ala His Lys Ser Phe Leu Val Ile Asp Asn Val Met Thr Glu Asp Ala 
                165                 170                 175     


Gly Asp Tyr Thr Cys Lys Phe Ile His Asn Glu Asn Gly Ala Asn Tyr 
            180                 185                 190         


Ser Val Thr Ala Thr Arg Ser Phe Thr Val Lys Val Trp Cys Gln Ser 
        195                 200                 205             


Phe Cys Lys Leu Lys Lys Ser Leu Ile Phe Ser Asn Thr His Trp Ile 
    210                 215                 220                 


Gln Ser Leu Met Arg Gly Phe Val Met Val Tyr Tyr Gly Val His Lys 
225                 230                 235                 240 


Cys Cys Arg Val Val Phe Asn Leu Cys Leu Gln Tyr Phe Gln His His 
                245                 250                 255     


Gln Trp Pro 
            


<210>  6988
<211>  211
<212>  PRT
<213>  Homo Sapiens

<400>  6988

Met Tyr Ser Thr Val Ser Gly Ser Glu Lys Asn Ser Lys Ile Tyr Cys 
1               5                   10                  15      


Pro Thr Ile Asp Leu Tyr Asn Trp Thr Ala Pro Leu Glu Trp Phe Lys 
            20                  25                  30          


Asn Cys Gln Ala Leu Gln Gly Ser Arg Tyr Arg Ala His Lys Ser Phe 
        35                  40                  45              


Leu Val Ile Asp Asn Val Met Thr Glu Asp Ala Gly Asp Tyr Thr Cys 
    50                  55                  60                  


Lys Phe Ile His Asn Glu Asn Gly Ala Asn Tyr Ser Val Thr Ala Thr 
65                  70                  75                  80  


Arg Ser Phe Thr Val Lys Asp Glu Gln Gly Phe Ser Leu Phe Pro Val 
                85                  90                  95      


Ile Gly Ala Pro Ala Gln Asn Glu Ile Lys Glu Val Glu Ile Gly Lys 
            100                 105                 110         


Asn Ala Asn Leu Thr Cys Ser Ala Cys Phe Gly Lys Gly Thr Gln Phe 
        115                 120                 125             


Leu Ala Ala Val Leu Trp Gln Leu Asn Gly Thr Lys Ile Thr Asp Phe 
    130                 135                 140                 


Gly Glu Pro Arg Ile Gln Gln Glu Glu Gly Gln Asn Gln Ser Phe Ser 
145                 150                 155                 160 


Asn Gly Leu Ala Cys Leu Asp Met Val Leu Arg Ile Ala Asp Val Lys 
                165                 170                 175     


Glu Glu Asp Leu Leu Leu Gln Tyr Asp Cys Leu Ala Leu Asn Leu His 
            180                 185                 190         


Gly Leu Arg Arg His Thr Val Arg Leu Ser Arg Lys Asn Pro Ser Lys 
        195                 200                 205             


Glu Cys Phe 
    210     


<210>  6989
<211>  457
<212>  PRT
<213>  Homo Sapiens

<400>  6989

Met Thr Gly Leu Val Ser Leu Ser Tyr Phe Pro Leu Ser Thr Arg Ser 
1               5                   10                  15      


Cys Ala Leu Gln Ser Cys Ser Pro Val Trp Gly Cys Gly Pro Cys Cys 
            20                  25                  30          


Ser Ala Gly Cys Pro Ser Pro Phe His Cys Leu Ser Gln Gln Asp Cys 
        35                  40                  45              


Asn Glu Ile Lys Gly Glu Arg Phe Thr Val Leu Glu Thr Arg Leu Leu 
    50                  55                  60                  


Val Ser Asn Val Ser Ala Glu Asp Arg Gly Asn Tyr Ala Cys Gln Ala 
65                  70                  75                  80  


Ile Leu Thr His Ser Gly Lys Gln Tyr Glu Val Leu Asn Gly Ile Thr 
                85                  90                  95      


Val Ser Ile Lys Arg Ala Gly Tyr Gly Gly Ser Val Pro Lys Ile Ile 
            100                 105                 110         


Tyr Pro Lys Asn His Ser Ile Glu Val Gln Leu Gly Thr Thr Leu Ile 
        115                 120                 125             


Val Asp Cys Asn Val Thr Asp Thr Lys Asp Asn Thr Asn Leu Arg Cys 
    130                 135                 140                 


Trp Arg Val Asn Asn Thr Leu Val Asp Asp Tyr Tyr Asp Glu Ser Lys 
145                 150                 155                 160 


Arg Ile Arg Glu Gly Val Glu Thr His Val Ser Phe Arg Glu His Asn 
                165                 170                 175     


Leu Tyr Thr Val Asn Ile Thr Phe Leu Glu Val Lys Met Glu Asp Tyr 
            180                 185                 190         


Gly Leu Pro Phe Met Cys His Ala Gly Val Ser Thr Ala Tyr Ile Ile 
        195                 200                 205             


Leu Gln Leu Pro Ala Pro Asp Phe Arg Ala Tyr Leu Ile Gly Gly Leu 
    210                 215                 220                 


Ile Ala Leu Val Ala Val Ala Val Ser Val Val Tyr Ile Tyr Asn Ile 
225                 230                 235                 240 


Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg Ser Ala Phe His Ser Thr 
                245                 250                 255     


Glu Thr Ile Val Asp Gly Lys Leu Tyr Asp Ala Tyr Val Leu Tyr Pro 
            260                 265                 270         


Lys Pro His Lys Glu Ser Gln Arg His Ala Val Asp Ala Leu Val Leu 
        275                 280                 285             


Asn Ile Leu Pro Glu Val Leu Glu Arg Gln Cys Gly Tyr Lys Leu Phe 
    290                 295                 300                 


Ile Phe Gly Arg Asp Glu Phe Pro Gly Gln Ala Val Ala Asn Val Ile 
305                 310                 315                 320 


Asp Glu Asn Val Lys Leu Cys Arg Arg Leu Ile Val Ile Val Val Pro 
                325                 330                 335     


Glu Ser Leu Gly Phe Gly Leu Leu Lys Asn Leu Ser Glu Glu Gln Ile 
            340                 345                 350         


Ala Val Tyr Ser Ala Leu Ile Gln Asp Gly Met Lys Val Ile Leu Ile 
        355                 360                 365             


Glu Leu Glu Lys Ile Glu Asp Tyr Thr Val Met Pro Glu Ser Ile Gln 
    370                 375                 380                 


Tyr Ile Lys Gln Lys His Gly Ala Ile Arg Trp His Gly Asp Phe Thr 
385                 390                 395                 400 


Glu Gln Ser Gln Cys Met Lys Thr Lys Phe Trp Lys Thr Val Arg Tyr 
                405                 410                 415     


His Met Pro Pro Arg Arg Cys Arg Pro Phe Pro Pro Val Gln Leu Leu 
            420                 425                 430         


Gln His Thr Pro Cys Tyr Arg Thr Ala Gly Pro Glu Leu Gly Ser Arg 
        435                 440                 445             


Arg Lys Lys Cys Thr Leu Thr Thr Gly 
    450                 455         


<210>  6990
<211>  172
<212>  PRT
<213>  Homo Sapiens

<400>  6990

Met Trp Ser Leu Leu Leu Cys Gly Leu Ser Ile Ala Leu Pro Leu Ser 
1               5                   10                  15      


Val Thr Ala Asp Gly Cys Lys Asp Ile Phe Met Lys Asn Glu Ile Leu 
            20                  25                  30          


Ser Ala Ser Gln Pro Phe Ala Phe Asn Cys Thr Phe Pro Pro Ile Thr 
        35                  40                  45              


Ser Gly Glu Val Ser Val Thr Trp Tyr Lys Asn Ser Ser Lys Ile Pro 
    50                  55                  60                  


Val Ser Lys Ile Ile Gln Ser Arg Ile His Gln Asp Glu Thr Trp Ile 
65                  70                  75                  80  


Leu Phe Leu Pro Met Glu Trp Gly Asp Ser Gly Val Tyr Gln Cys Val 
                85                  90                  95      


Ile Lys Gly Arg Asp Ser Cys His Arg Ile His Val Asn Leu Thr Val 
            100                 105                 110         


Phe Glu Lys His Trp Cys Asp Thr Ser Ile Gly Gly Leu Pro Asn Leu 
        115                 120                 125             


Ser Asp Glu Tyr Lys Gln Ile Leu His Leu Gly Lys Asp Asp Ser Leu 
    130                 135                 140                 


Thr Cys His Leu His Phe Pro Lys Ser Cys Val Leu Gly Pro Ile Lys 
145                 150                 155                 160 


Trp Tyr Lys Asp Cys Asn Glu Ile Lys Gly Glu Arg 
                165                 170         


<210>  6991
<211>  575
<212>  PRT
<213>  Homo Sapiens

<400>  6991

Met Trp Ser Leu Leu Leu Cys Gly Leu Ser Ile Ala Leu Pro Leu Ser 
1               5                   10                  15      


Val Thr Ala Asp Gly Cys Lys Asp Ile Phe Met Lys Asn Glu Ile Leu 
            20                  25                  30          


Ser Ala Ser Gln Pro Phe Ala Phe Asn Cys Thr Phe Pro Pro Ile Thr 
        35                  40                  45              


Ser Gly Glu Val Ser Val Thr Trp Tyr Lys Asn Ser Ser Lys Ile Pro 
    50                  55                  60                  


Val Ser Lys Ile Ile Gln Ser Arg Ile His Gln Asp Glu Thr Trp Ile 
65                  70                  75                  80  


Leu Phe Leu Pro Met Glu Trp Gly Asp Ser Gly Val Tyr Gln Cys Val 
                85                  90                  95      


Ile Lys Gly Arg Asp Ser Cys His Arg Ile His Val Asn Leu Thr Val 
            100                 105                 110         


Phe Glu Lys His Trp Cys Asp Thr Ser Ile Gly Gly Leu Pro Asn Leu 
        115                 120                 125             


Ser Asp Glu Tyr Lys Gln Ile Leu His Leu Gly Lys Asp Asp Ser Leu 
    130                 135                 140                 


Thr Cys His Leu His Phe Pro Lys Ser Cys Val Leu Gly Pro Ile Lys 
145                 150                 155                 160 


Trp Tyr Lys Asp Cys Asn Glu Ile Lys Gly Glu Arg Phe Thr Val Leu 
                165                 170                 175     


Glu Thr Arg Leu Leu Val Ser Asn Val Ser Ala Glu Asp Arg Gly Asn 
            180                 185                 190         


Tyr Ala Cys Gln Ala Ile Leu Thr His Ser Gly Lys Gln Tyr Glu Val 
        195                 200                 205             


Leu Asn Gly Ile Thr Val Ser Ile Thr Glu Arg Ala Gly Tyr Gly Gly 
    210                 215                 220                 


Ser Val Pro Lys Ile Ile Tyr Pro Lys Asn His Ser Ile Glu Val Gln 
225                 230                 235                 240 


Leu Gly Thr Thr Leu Ile Val Asp Cys Asn Val Thr Asp Thr Lys Asp 
                245                 250                 255     


Asn Thr Asn Leu Arg Cys Trp Arg Val Asn Asn Thr Leu Val Asp Asp 
            260                 265                 270         


Tyr Tyr Asp Glu Ser Lys Arg Ile Arg Glu Gly Val Glu Thr His Val 
        275                 280                 285             


Ser Phe Arg Glu His Asn Leu Tyr Thr Val Asn Ile Thr Phe Leu Glu 
    290                 295                 300                 


Val Lys Met Glu Asp Tyr Gly Leu Pro Phe Met Cys His Ala Gly Val 
305                 310                 315                 320 


Ser Thr Ala Tyr Ile Ile Leu Gln Leu Pro Ala Pro Asp Phe Arg Ala 
                325                 330                 335     


Tyr Leu Ile Gly Gly Leu Ile Ala Leu Val Ala Val Ala Val Ser Val 
            340                 345                 350         


Val Tyr Ile Tyr Asn Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             


Ser Ala Phe His Ser Thr Glu Thr Ile Val Asp Gly Lys Leu Tyr Asp 
    370                 375                 380                 


Ala Tyr Val Leu Tyr Pro Lys Pro His Lys Glu Ser Gln Arg His Ala 
385                 390                 395                 400 


Val Asp Ala Leu Val Leu Asn Ile Leu Pro Glu Val Leu Glu Arg Gln 
                405                 410                 415     


Cys Gly Tyr Lys Leu Phe Ile Phe Gly Arg Asp Glu Phe Pro Gly Gln 
            420                 425                 430         


Ala Val Ala Asn Val Ile Asp Glu Asn Val Lys Leu Cys Arg Arg Leu 
        435                 440                 445             


Ile Val Ile Val Val Pro Glu Ser Leu Gly Phe Gly Leu Leu Lys Asn 
    450                 455                 460                 


Leu Ser Glu Glu Gln Ile Ala Val Tyr Ser Ala Leu Ile Gln Asp Gly 
465                 470                 475                 480 


Met Lys Val Ile Leu Ile Glu Leu Glu Lys Ile Glu Asp Tyr Thr Val 
                485                 490                 495     


Met Pro Glu Ser Ile Gln Tyr Ile Lys Gln Lys His Gly Ala Ile Arg 
            500                 505                 510         


Trp His Gly Asp Phe Thr Glu Gln Ser Gln Cys Met Lys Thr Lys Phe 
        515                 520                 525             


Trp Lys Thr Val Arg Tyr His Met Pro Pro Arg Arg Cys Arg Pro Phe 
    530                 535                 540                 


Pro Pro Val Gln Leu Leu Gln His Thr Pro Cys Tyr Arg Thr Ala Gly 
545                 550                 555                 560 


Pro Glu Leu Gly Ser Arg Arg Lys Lys Cys Thr Leu Thr Thr Gly 
                565                 570                 575 


<210>  6992
<211>  180
<212>  PRT
<213>  Homo Sapiens

<400>  6992

Met Ala Leu Ala Asp Leu Tyr Glu Glu Gly Gly Gly Gly Gly Gly Glu 
1               5                   10                  15      


Gly Glu Asp Asn Ala Asp Ser Lys Glu Thr Ile Cys Arg Pro Ser Gly 
            20                  25                  30          


Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln 
        35                  40                  45              


Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln 
    50                  55                  60                  


Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu 
65                  70                  75                  80  


Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser 
                85                  90                  95      


Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn 
            100                 105                 110         


Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe 
        115                 120                 125             


Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys 
    130                 135                 140                 


Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser 
145                 150                 155                 160 


Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe 
                165                 170                 175     


Gln Glu Asp Glu 
            180 


<210>  6993
<211>  159
<212>  PRT
<213>  Homo Sapiens

<400>  6993

Met Ala Leu Glu Thr Ile Cys Arg Pro Ser Gly Arg Lys Ser Ser Lys 
1               5                   10                  15      


Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu 
            20                  25                  30          


Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn 
        35                  40                  45              


Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe 
    50                  55                  60                  


Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly 
65                  70                  75                  80  


Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser 
                85                  90                  95      


Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser 
            100                 105                 110         


Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu 
        115                 120                 125             


Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro 
    130                 135                 140                 


Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150                 155                 


<210>  6994
<211>  177
<212>  PRT
<213>  Homo Sapiens

<400>  6994

Met Glu Ile Cys Arg Gly Leu Arg Ser His Leu Ile Thr Leu Leu Leu 
1               5                   10                  15      


Phe Leu Phe His Ser Glu Thr Ile Cys Arg Pro Ser Gly Arg Lys Ser 
            20                  25                  30          


Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe 
        35                  40                  45              


Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn 
    50                  55                  60                  


Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala 
65                  70                  75                  80  


Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys 
                85                  90                  95      


Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp 
            100                 105                 110         


Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser 
        115                 120                 125             


Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp 
    130                 135                 140                 


Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn 
145                 150                 155                 160 


Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp 
                165                 170                 175     


Glu 
    


<210>  6995
<211>  143
<212>  PRT
<213>  Homo Sapiens

<400>  6995

Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu 
1               5                   10                  15      


Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn 
            20                  25                  30          


Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe 
        35                  40                  45              


Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly 
    50                  55                  60                  


Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser 
65                  70                  75                  80  


Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser 
                85                  90                  95      


Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu 
            100                 105                 110         


Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro 
        115                 120                 125             


Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
    130                 135                 140             


<210>  6996
<211>  143
<212>  PRT
<213>  Homo Sapiens

<400>  6996

Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu 
1               5                   10                  15      


Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn 
            20                  25                  30          


Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe 
        35                  40                  45              


Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly 
    50                  55                  60                  


Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser 
65                  70                  75                  80  


Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser 
                85                  90                  95      


Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu 
            100                 105                 110         


Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro 
        115                 120                 125             


Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
    130                 135                 140             


<210>  6997
<211>  153
<212>  PRT
<213>  Homo Sapiens

<400>  6997

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210>  6998
<211>  176
<212>  PRT
<213>  Homo Sapiens

<400>  6998

Met Lys Ala Ser Ser Leu Ala Phe Ser Leu Leu Ser Ala Ala Phe Tyr 
1               5                   10                  15      


Leu Leu Trp Thr Pro Ser Thr Gly Leu Lys Thr Leu Asn Leu Gly Ser 
            20                  25                  30          


Cys Val Ile Ala Thr Asn Leu Gln Glu Ile Arg Asn Gly Phe Ser Glu 
        35                  40                  45              


Ile Arg Gly Ser Val Gln Ala Lys Asp Gly Asn Ile Asp Ile Arg Ile 
    50                  55                  60                  


Leu Arg Arg Thr Glu Ser Leu Gln Asp Thr Lys Pro Ala Asn Arg Cys 
65                  70                  75                  80  


Cys Leu Leu Arg His Leu Leu Arg Leu Tyr Leu Asp Arg Val Phe Lys 
                85                  90                  95      


Asn Tyr Gln Thr Pro Asp His Tyr Thr Leu Arg Lys Ile Ser Ser Leu 
            100                 105                 110         


Ala Asn Ser Phe Leu Thr Ile Lys Lys Asp Leu Arg Leu Cys His Ala 
        115                 120                 125             


His Met Thr Cys His Cys Gly Glu Glu Ala Met Lys Lys Tyr Ser Gln 
    130                 135                 140                 


Ile Leu Ser His Phe Glu Lys Leu Glu Pro Gln Ala Ala Val Val Lys 
145                 150                 155                 160 


Ala Leu Gly Glu Leu Asp Ile Leu Leu Gln Trp Met Glu Glu Thr Glu 
                165                 170                 175     


<210>  6999
<211>  176
<212>  PRT
<213>  Homo Sapiens

<400>  6999

Met Lys Ala Ser Ser Leu Ala Phe Ser Leu Leu Ser Ala Ala Phe Tyr 
1               5                   10                  15      


Leu Leu Trp Thr Pro Ser Thr Gly Leu Lys Thr Leu Asn Leu Gly Ser 
            20                  25                  30          


Cys Val Ile Ala Thr Asn Leu Gln Glu Ile Arg Asn Gly Phe Ser Glu 
        35                  40                  45              


Ile Arg Gly Ser Val Gln Ala Lys Asp Gly Asn Ile Asp Ile Arg Ile 
    50                  55                  60                  


Leu Arg Arg Thr Glu Ser Leu Gln Asp Thr Lys Pro Ala Asn Arg Cys 
65                  70                  75                  80  


Cys Leu Leu Arg His Leu Leu Arg Leu Tyr Leu Asp Arg Val Phe Lys 
                85                  90                  95      


Asn Tyr Gln Thr Pro Asp His Tyr Thr Leu Arg Lys Ile Ser Ser Leu 
            100                 105                 110         


Ala Asn Ser Phe Leu Thr Ile Lys Lys Asp Leu Arg Leu Cys His Ala 
        115                 120                 125             


His Met Thr Cys His Cys Gly Glu Glu Ala Met Lys Lys Tyr Ser Gln 
    130                 135                 140                 


Ile Leu Ser His Phe Glu Lys Leu Glu Pro Gln Ala Ala Val Val Lys 
145                 150                 155                 160 


Ala Leu Gly Glu Leu Asp Ile Leu Leu Gln Trp Met Glu Glu Thr Glu 
                165                 170                 175     


<210>  7000
<211>  151
<212>  PRT
<213>  Homo Sapiens

<400>  7000

Met Lys Ala Ser Ser Leu Ala Phe Ser Leu Leu Ser Ala Ala Phe Tyr 
1               5                   10                  15      


Leu Leu Trp Thr Pro Ser Thr Gly Leu Lys Thr Leu Asn Leu Gly Ser 
            20                  25                  30          


Cys Val Ile Ala Thr Asn Leu Gln Glu Ile Arg Asn Gly Phe Ser Glu 
        35                  40                  45              


Ile Arg Gly Ser Val Gln Ala Lys Asp Gly Asn Ile Asp Ile Arg Ile 
    50                  55                  60                  


Leu Arg Arg Thr Glu Ser Leu Gln Asp Thr Lys Pro Ala Asn Arg Cys 
65                  70                  75                  80  


Cys Leu Leu Arg His Leu Leu Arg Leu Tyr Leu Asp Arg Val Phe Lys 
                85                  90                  95      


Asn Tyr Gln Thr Pro Asp His Tyr Thr Leu Arg Lys Ile Ser Ser Leu 
            100                 105                 110         


Ala Asn Ser Phe Leu Thr Ile Lys Lys Asp Leu Arg Leu Cys Leu Glu 
        115                 120                 125             


Pro Gln Ala Ala Val Val Lys Ala Leu Gly Glu Leu Asp Ile Leu Leu 
    130                 135                 140                 


Gln Trp Met Glu Glu Thr Glu 
145                 150     


<210>  7001
<211>  504
<212>  PRT
<213>  Homo Sapiens

<400>  7001

Met Lys Asn Val Leu Gln Trp Thr Pro Pro Glu Gly Leu Gln Gly Val 
1               5                   10                  15      


Lys Val Thr Tyr Thr Val Gln Tyr Phe Ile Tyr Gly Gln Lys Lys Trp 
            20                  25                  30          


Leu Asn Lys Ser Glu Cys Arg Asn Ile Asn Arg Thr Tyr Cys Asp Leu 
        35                  40                  45              


Ser Ala Glu Thr Ser Asp Tyr Glu His Gln Tyr Tyr Ala Lys Val Lys 
    50                  55                  60                  


Ala Ile Trp Gly Thr Lys Cys Ser Lys Trp Ala Glu Ser Gly Arg Phe 
65                  70                  75                  80  


Tyr Pro Phe Leu Glu Thr Gln Ile Gly Pro Pro Glu Val Ala Leu Thr 
                85                  90                  95      


Thr Asp Glu Lys Ser Ile Ser Val Val Leu Thr Ala Pro Glu Lys Trp 
            100                 105                 110         


Lys Arg Asn Pro Glu Asp Leu Pro Val Ser Met Gln Gln Ile Tyr Ser 
        115                 120                 125             


Asn Leu Lys Tyr Asn Val Ser Val Leu Asn Thr Lys Ser Asn Arg Thr 
    130                 135                 140                 


Trp Ser Gln Cys Val Thr Asn His Thr Leu Val Leu Thr Trp Leu Glu 
145                 150                 155                 160 


Pro Asn Thr Leu Tyr Cys Val His Val Glu Ser Phe Val Pro Gly Pro 
                165                 170                 175     


Pro Arg Arg Ala Gln Pro Ser Glu Lys Gln Cys Ala Arg Thr Leu Lys 
            180                 185                 190         


Asp Gln Ser Ser Glu Phe Lys Ala Lys Ile Ile Phe Trp Tyr Val Leu 
        195                 200                 205             


Pro Val Ser Ile Thr Val Phe Leu Phe Ser Val Met Gly Tyr Ser Ile 
    210                 215                 220                 


Tyr Arg Tyr Ile His Val Gly Lys Glu Lys His Pro Ala Asn Leu Ile 
225                 230                 235                 240 


Leu Ile Tyr Gly Asn Glu Phe Asp Lys Arg Phe Phe Val Pro Ala Glu 
                245                 250                 255     


Lys Ile Val Ile Asn Phe Ile Thr Leu Asn Ile Ser Asp Asp Ser Lys 
            260                 265                 270         


Ile Ser His Gln Asp Met Ser Leu Leu Gly Lys Ser Ser Asp Val Ser 
        275                 280                 285             


Ser Leu Asn Asp Pro Gln Pro Ser Gly Asn Leu Arg Pro Pro Gln Glu 
    290                 295                 300                 


Glu Glu Glu Val Lys His Leu Gly Tyr Ala Ser His Leu Met Glu Ile 
305                 310                 315                 320 


Phe Cys Asp Ser Glu Glu Asn Thr Glu Gly Thr Ser Leu Thr Gln Gln 
                325                 330                 335     


Glu Ser Leu Ser Arg Thr Ile Pro Pro Asp Lys Thr Val Ile Glu Tyr 
            340                 345                 350         


Glu Tyr Asp Val Arg Thr Thr Asp Ile Cys Ala Gly Pro Glu Glu Gln 
        355                 360                 365             


Glu Leu Ser Leu Gln Glu Glu Val Ser Thr Gln Gly Thr Leu Leu Glu 
    370                 375                 380                 


Ser Gln Ala Ala Leu Ala Val Leu Gly Pro Gln Thr Leu Gln Tyr Ser 
385                 390                 395                 400 


Tyr Thr Pro Gln Leu Gln Asp Leu Asp Pro Leu Ala Gln Glu His Thr 
                405                 410                 415     


Asp Ser Glu Glu Gly Pro Glu Glu Glu Pro Ser Thr Thr Leu Val Asp 
            420                 425                 430         


Trp Asp Pro Gln Thr Gly Arg Leu Cys Ile Pro Ser Leu Ser Ser Phe 
        435                 440                 445             


Asp Gln Asp Ser Glu Gly Cys Glu Pro Ser Glu Gly Asp Gly Leu Gly 
    450                 455                 460                 


Glu Glu Gly Leu Leu Ser Arg Leu Tyr Glu Glu Pro Ala Pro Asp Arg 
465                 470                 475                 480 


Pro Pro Gly Glu Asn Glu Thr Tyr Leu Met Gln Phe Met Glu Glu Trp 
                485                 490                 495     


Gly Leu Tyr Val Gln Met Glu Asn 
            500                 


<210>  7002
<211>  42
<212>  PRT
<213>  Homo Sapiens

<400>  7002

Met Arg Ala Pro Gly Arg Pro Ala Leu Arg Pro Leu Pro Leu Pro Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Ala Ala Pro Trp Gly Arg Ala Gly Tyr Ser 
            20                  25                  30          


Arg Pro Leu Leu Gly Leu Trp Ala Lys Val 
        35                  40          


<210>  7003
<211>  209
<212>  PRT
<213>  Homo Sapiens

<400>  7003

Met Arg Ala Pro Gly Arg Pro Ala Leu Arg Pro Leu Pro Leu Pro Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Ala Ala Pro Trp Gly Arg Ala Val Pro Cys 
            20                  25                  30          


Val Ser Gly Gly Leu Pro Lys Pro Ala Asn Ile Thr Phe Leu Ser Ile 
        35                  40                  45              


Asn Met Lys Asn Val Leu Gln Trp Thr Pro Pro Glu Gly Leu Gln Gly 
    50                  55                  60                  


Val Lys Val Thr Tyr Thr Val Gln Tyr Phe Ile Tyr Gly Gln Lys Lys 
65                  70                  75                  80  


Trp Leu Asn Lys Ser Glu Cys Arg Asn Ile Asn Arg Thr Tyr Cys Asp 
                85                  90                  95      


Leu Ser Ala Glu Thr Ser Asp Tyr Glu His Gln Tyr Tyr Ala Lys Val 
            100                 105                 110         


Lys Ala Ile Trp Gly Thr Lys Cys Ser Lys Trp Ala Glu Ser Gly Arg 
        115                 120                 125             


Phe Tyr Pro Phe Leu Glu Thr Gln Ile Gly Pro Pro Glu Val Ala Leu 
    130                 135                 140                 


Thr Thr Asp Glu Lys Ser Ile Ser Val Val Leu Thr Ala Pro Glu Lys 
145                 150                 155                 160 


Trp Lys Arg Asn Pro Glu Asp Leu Pro Val Ser Met Gln Gln Ile Tyr 
                165                 170                 175     


Ser Asn Leu Lys Tyr Asn Val Ser Val Leu Asn Thr Lys Ser Asn Arg 
            180                 185                 190         


Thr Val Ser Leu Lys Trp Asn Gly Ala Tyr Ile His Val Pro Leu Cys 
        195                 200                 205             


Ser 
    


<210>  7004
<211>  553
<212>  PRT
<213>  Homo Sapiens

<400>  7004

Met Arg Ala Pro Gly Arg Pro Ala Leu Arg Pro Leu Pro Leu Pro Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Ala Ala Pro Trp Gly Arg Ala Val Pro Cys 
            20                  25                  30          


Val Ser Gly Gly Leu Pro Lys Pro Ala Asn Ile Thr Phe Leu Ser Ile 
        35                  40                  45              


Asn Met Lys Asn Val Leu Gln Trp Thr Pro Pro Glu Gly Leu Gln Gly 
    50                  55                  60                  


Val Lys Val Thr Tyr Thr Val Gln Tyr Phe Ile Tyr Gly Gln Lys Lys 
65                  70                  75                  80  


Trp Leu Asn Lys Ser Glu Cys Arg Asn Ile Asn Arg Thr Tyr Cys Asp 
                85                  90                  95      


Leu Ser Ala Glu Thr Ser Asp Tyr Glu His Gln Tyr Tyr Ala Lys Val 
            100                 105                 110         


Lys Ala Ile Trp Gly Thr Lys Cys Ser Lys Trp Ala Glu Ser Gly Arg 
        115                 120                 125             


Phe Tyr Pro Phe Leu Glu Thr Gln Ile Gly Pro Pro Glu Val Ala Leu 
    130                 135                 140                 


Thr Thr Asp Glu Lys Ser Ile Ser Val Val Leu Thr Ala Pro Glu Lys 
145                 150                 155                 160 


Trp Lys Arg Asn Pro Glu Asp Leu Pro Val Ser Met Gln Gln Ile Tyr 
                165                 170                 175     


Ser Asn Leu Lys Tyr Asn Val Ser Val Leu Asn Thr Lys Ser Asn Arg 
            180                 185                 190         


Thr Trp Ser Gln Cys Val Thr Asn His Thr Leu Val Leu Thr Trp Leu 
        195                 200                 205             


Glu Pro Asn Thr Leu Tyr Cys Val His Val Glu Ser Phe Val Pro Gly 
    210                 215                 220                 


Pro Pro Arg Arg Ala Gln Pro Ser Glu Lys Gln Cys Ala Arg Thr Leu 
225                 230                 235                 240 


Lys Asp Gln Ser Ser Glu Phe Lys Ala Lys Ile Ile Phe Trp Tyr Val 
                245                 250                 255     


Leu Pro Val Ser Ile Thr Val Phe Leu Phe Ser Val Met Gly Tyr Ser 
            260                 265                 270         


Ile Tyr Arg Tyr Ile His Val Gly Lys Glu Lys His Pro Ala Asn Leu 
        275                 280                 285             


Ile Leu Ile Tyr Gly Asn Glu Phe Asp Lys Arg Phe Phe Val Pro Ala 
    290                 295                 300                 


Glu Lys Ile Val Ile Asn Phe Ile Thr Leu Asn Ile Ser Asp Asp Ser 
305                 310                 315                 320 


Lys Ile Ser His Gln Asp Met Ser Leu Leu Gly Lys Ser Ser Asp Val 
                325                 330                 335     


Ser Ser Leu Asn Asp Pro Gln Pro Ser Gly Asn Leu Arg Pro Pro Gln 
            340                 345                 350         


Glu Glu Glu Glu Val Lys His Leu Gly Tyr Ala Ser His Leu Met Glu 
        355                 360                 365             


Ile Phe Cys Asp Ser Glu Glu Asn Thr Glu Gly Thr Ser Leu Thr Gln 
    370                 375                 380                 


Gln Glu Ser Leu Ser Arg Thr Ile Pro Pro Asp Lys Thr Val Ile Glu 
385                 390                 395                 400 


Tyr Glu Tyr Asp Val Arg Thr Thr Asp Ile Cys Ala Gly Pro Glu Glu 
                405                 410                 415     


Gln Glu Leu Ser Leu Gln Glu Glu Val Ser Thr Gln Gly Thr Leu Leu 
            420                 425                 430         


Glu Ser Gln Ala Ala Leu Ala Val Leu Gly Pro Gln Thr Leu Gln Tyr 
        435                 440                 445             


Ser Tyr Thr Pro Gln Leu Gln Asp Leu Asp Pro Leu Ala Gln Glu His 
    450                 455                 460                 


Thr Asp Ser Glu Glu Gly Pro Glu Glu Glu Pro Ser Thr Thr Leu Val 
465                 470                 475                 480 


Asp Trp Asp Pro Gln Thr Gly Arg Leu Cys Ile Pro Ser Leu Ser Ser 
                485                 490                 495     


Phe Asp Gln Asp Ser Glu Gly Cys Glu Pro Ser Glu Gly Asp Gly Leu 
            500                 505                 510         


Gly Glu Glu Gly Leu Leu Ser Arg Leu Tyr Glu Glu Pro Ala Pro Asp 
        515                 520                 525             


Arg Pro Pro Gly Glu Asn Glu Thr Tyr Leu Met Gln Phe Met Glu Glu 
    530                 535                 540                 


Trp Gly Leu Tyr Val Gln Met Glu Asn 
545                 550             


<210>  7005
<211>  89
<212>  PRT
<213>  Homo Sapiens

<400>  7005

Met Ser Tyr Asn Gly Leu His Gln Arg Val Phe Lys Glu Leu Lys Leu 
1               5                   10                  15      


Leu Thr Leu Cys Ser Ile Ser Ser Pro Glu Lys Trp Lys Arg Asn Pro 
            20                  25                  30          


Glu Asp Leu Pro Val Ser Met Gln Gln Ile Tyr Ser Asn Leu Lys Tyr 
        35                  40                  45              


Asn Val Ser Val Leu Asn Thr Lys Ser Asn Arg Thr Trp Ser Gln Cys 
    50                  55                  60                  


Val Thr Asn His Thr Leu Val Leu Thr Trp Leu Glu Pro Asn Thr Leu 
65                  70                  75                  80  


Tyr Cys Val His Val Glu Ser Phe Val 
                85                  


<210>  7006
<211>  177
<212>  PRT
<213>  Homo Sapiens

<400>  7006

Met Ser Tyr Asn Gly Leu His Gln Arg Val Phe Lys Glu Leu Lys Leu 
1               5                   10                  15      


Leu Thr Leu Cys Ser Ile Ser Ser Gln Ile Gly Pro Pro Glu Val Ala 
            20                  25                  30          


Leu Thr Thr Asp Glu Lys Ser Ile Ser Val Val Leu Thr Ala Pro Glu 
        35                  40                  45              


Lys Trp Lys Arg Asn Pro Glu Asp Leu Pro Val Ser Met Gln Gln Ile 
    50                  55                  60                  


Tyr Ser Asn Leu Lys Tyr Asn Val Ser Val Leu Asn Thr Lys Ser Asn 
65                  70                  75                  80  


Arg Thr Trp Ser Gln Cys Val Thr Asn His Thr Leu Val Leu Thr Trp 
                85                  90                  95      


Leu Glu Pro Asn Thr Leu Tyr Cys Val His Val Glu Ser Phe Val Pro 
            100                 105                 110         


Gly Pro Pro Arg Arg Ala Gln Pro Ser Glu Lys Gln Cys Ala Arg Thr 
        115                 120                 125             


Leu Lys Asp Gln Ser Ser Glu Phe Lys Ala Lys Ile Ile Phe Trp Tyr 
    130                 135                 140                 


Val Leu Pro Val Ser Ile Thr Val Phe Leu Phe Ser Val Met Gly Tyr 
145                 150                 155                 160 


Ser Ile Tyr Arg Tyr Ile His Val Gly Lys Glu Lys His Pro Ala Asn 
                165                 170                 175     


Leu 
    


<210>  7007
<211>  442
<212>  PRT
<213>  Homo Sapiens

<400>  7007

Met Ser Tyr Asn Gly Leu His Gln Arg Val Phe Lys Glu Leu Lys Leu 
1               5                   10                  15      


Leu Thr Leu Cys Ser Ile Ser Ser Gln Ile Gly Pro Pro Glu Val Ala 
            20                  25                  30          


Leu Thr Thr Asp Glu Lys Ser Ile Ser Val Val Leu Thr Ala Pro Glu 
        35                  40                  45              


Lys Trp Lys Arg Asn Pro Glu Asp Leu Pro Val Ser Met Gln Gln Ile 
    50                  55                  60                  


Tyr Ser Asn Leu Lys Tyr Asn Val Ser Val Leu Asn Thr Lys Ser Asn 
65                  70                  75                  80  


Arg Thr Trp Ser Gln Cys Val Thr Asn His Thr Leu Val Leu Thr Trp 
                85                  90                  95      


Leu Glu Pro Asn Thr Leu Tyr Cys Val His Val Glu Ser Phe Val Pro 
            100                 105                 110         


Gly Pro Pro Arg Arg Ala Gln Pro Ser Glu Lys Gln Cys Ala Arg Thr 
        115                 120                 125             


Leu Lys Asp Gln Ser Ser Glu Phe Lys Ala Lys Ile Ile Phe Trp Tyr 
    130                 135                 140                 


Val Leu Pro Val Ser Ile Thr Val Phe Leu Phe Ser Val Met Gly Tyr 
145                 150                 155                 160 


Ser Ile Tyr Arg Tyr Ile His Val Gly Lys Glu Lys His Pro Ala Asn 
                165                 170                 175     


Leu Ile Leu Ile Tyr Gly Asn Glu Phe Asp Lys Arg Phe Phe Val Pro 
            180                 185                 190         


Ala Glu Lys Ile Val Ile Asn Phe Ile Thr Leu Asn Ile Ser Asp Asp 
        195                 200                 205             


Ser Lys Ile Ser His Gln Asp Met Ser Leu Leu Gly Lys Ser Ser Asp 
    210                 215                 220                 


Val Ser Ser Leu Asn Asp Pro Gln Pro Ser Gly Asn Leu Arg Pro Pro 
225                 230                 235                 240 


Gln Glu Glu Glu Glu Val Lys His Leu Gly Tyr Ala Ser His Leu Met 
                245                 250                 255     


Glu Ile Phe Cys Asp Ser Glu Glu Asn Thr Glu Gly Thr Ser Leu Thr 
            260                 265                 270         


Gln Gln Glu Ser Leu Ser Arg Thr Ile Pro Pro Asp Lys Thr Val Ile 
        275                 280                 285             


Glu Tyr Glu Tyr Asp Val Arg Thr Thr Asp Ile Cys Ala Gly Pro Glu 
    290                 295                 300                 


Glu Gln Glu Leu Ser Leu Gln Glu Glu Val Ser Thr Gln Gly Thr Leu 
305                 310                 315                 320 


Leu Glu Ser Gln Ala Ala Leu Ala Val Leu Gly Pro Gln Thr Leu Gln 
                325                 330                 335     


Tyr Ser Tyr Thr Pro Gln Leu Gln Asp Leu Asp Pro Leu Ala Gln Glu 
            340                 345                 350         


His Thr Asp Ser Glu Glu Gly Pro Glu Glu Glu Pro Ser Thr Thr Leu 
        355                 360                 365             


Val Asp Trp Asp Pro Gln Thr Gly Arg Leu Cys Ile Pro Ser Leu Ser 
    370                 375                 380                 


Ser Phe Asp Gln Asp Ser Glu Gly Cys Glu Pro Ser Glu Gly Asp Gly 
385                 390                 395                 400 


Leu Gly Glu Glu Gly Leu Leu Ser Arg Leu Tyr Glu Glu Pro Ala Pro 
                405                 410                 415     


Asp Arg Pro Pro Gly Glu Asn Glu Thr Tyr Leu Met Gln Phe Met Glu 
            420                 425                 430         


Glu Trp Gly Leu Tyr Val Gln Met Glu Asn 
        435                 440         


<210>  7008
<211>  162
<212>  PRT
<213>  Homo Sapiens

<400>  7008

Met Arg Ser Ser Pro Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met 
1               5                   10                  15      


Val Ile Phe Leu Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln 
            20                  25                  30          


Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln 
        35                  40                  45              


Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro 
    50                  55                  60                  


Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln 
65                  70                  75                  80  


Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile 
                85                  90                  95      


Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala 
            100                 105                 110         


Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr 
        115                 120                 125             


Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu 
    130                 135                 140                 


Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu 
145                 150                 155                 160 


Asp Ser 
        


<210>  7009
<211>  153
<212>  PRT
<213>  Homo Sapiens

<400>  7009

Met Arg Ser Ser Pro Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met 
1               5                   10                  15      


Val Ile Phe Leu Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln 
            20                  25                  30          


Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln 
        35                  40                  45              


Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro 
    50                  55                  60                  


Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln 
65                  70                  75                  80  


Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile 
                85                  90                  95      


Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala 
            100                 105                 110         


Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr 
        115                 120                 125             


Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu 
    130                 135                 140                 


Gln Lys Val Ser Thr Leu Ser Phe Ile 
145                 150             


<210>  7010
<211>  179
<212>  PRT
<213>  Homo Sapiens

<400>  7010

Met Ala Ala Leu Gln Lys Ser Val Ser Ser Phe Leu Met Gly Thr Leu 
1               5                   10                  15      


Ala Thr Ser Cys Leu Leu Leu Leu Ala Leu Leu Val Gln Gly Gly Ala 
            20                  25                  30          


Ala Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln 
        35                  40                  45              


Gln Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser 
    50                  55                  60                  


Leu Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe 
65                  70                  75                  80  


His Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu 
                85                  90                  95      


Asn Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln 
            100                 105                 110         


Pro Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg 
        115                 120                 125             


Leu Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn 
    130                 135                 140                 


Val Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu 
145                 150                 155                 160 


Ile Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn 
                165                 170                 175     


Ala Cys Ile 
            


<210>  7011
<211>  179
<212>  PRT
<213>  Homo Sapiens

<400>  7011

Met Ala Ala Leu Gln Lys Ser Val Ser Ser Phe Leu Met Gly Thr Leu 
1               5                   10                  15      


Ala Thr Ser Cys Leu Leu Leu Leu Ala Leu Leu Val Gln Gly Gly Ala 
            20                  25                  30          


Ala Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln 
        35                  40                  45              


Gln Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser 
    50                  55                  60                  


Leu Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe 
65                  70                  75                  80  


His Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu 
                85                  90                  95      


Asn Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln 
            100                 105                 110         


Pro Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg 
        115                 120                 125             


Leu Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn 
    130                 135                 140                 


Val Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu 
145                 150                 155                 160 


Ile Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn 
                165                 170                 175     


Ala Cys Ile 
            


<210>  7012
<211>  263
<212>  PRT
<213>  Homo Sapiens

<400>  7012

Met Met Pro Lys His Cys Phe Leu Gly Phe Leu Ile Ser Phe Phe Leu 
1               5                   10                  15      


Thr Gly Val Ala Gly Thr Gln Ser Thr His Glu Ser Leu Lys Pro Gln 
            20                  25                  30          


Arg Val Gln Phe Gln Ser Arg Asn Phe His Asn Ile Leu Gln Trp Gln 
        35                  40                  45              


Pro Gly Arg Ala Leu Thr Gly Asn Ser Ser Val Tyr Phe Val Gln Tyr 
    50                  55                  60                  


Lys Ile Met Phe Ser Cys Ser Met Lys Ser Ser His Gln Lys Pro Ser 
65                  70                  75                  80  


Gly Cys Trp Gln His Ile Ser Cys Asn Phe Pro Gly Cys Arg Thr Leu 
                85                  90                  95      


Ala Lys Tyr Gly Gln Arg Gln Trp Lys Asn Lys Glu Asp Cys Trp Gly 
            100                 105                 110         


Thr Gln Glu Leu Ser Cys Asp Leu Thr Ser Glu Thr Ser Asp Ile Gln 
        115                 120                 125             


Glu Pro Tyr Tyr Gly Arg Val Arg Ala Ala Ser Ala Gly Ser Tyr Ser 
    130                 135                 140                 


Glu Trp Ser Met Thr Pro Arg Phe Thr Pro Trp Trp Glu Thr Lys Ile 
145                 150                 155                 160 


Asp Pro Pro Val Met Asn Ile Thr Gln Val Asn Gly Ser Leu Leu Val 
                165                 170                 175     


Ile Leu His Ala Pro Asn Leu Pro Tyr Arg Tyr Gln Lys Glu Lys Asn 
            180                 185                 190         


Val Ser Ile Glu Asp Tyr Tyr Glu Leu Leu Tyr Arg Val Phe Ile Ile 
        195                 200                 205             


Asn Asn Ser Leu Glu Lys Glu Gln Lys Val Tyr Glu Gly Ala His Arg 
    210                 215                 220                 


Ala Val Glu Ile Glu Ala Leu Thr Pro His Ser Ser Tyr Cys Val Val 
225                 230                 235                 240 


Ala Glu Ile Tyr Gln Pro Met Leu Asp Arg Arg Ser Gln Arg Ser Glu 
                245                 250                 255     


Glu Arg Cys Val Glu Ile Pro 
            260             


<210>  7013
<211>  130
<212>  PRT
<213>  Homo Sapiens

<400>  7013

Met Met Pro Lys His Cys Phe Leu Gly Phe Leu Ile Ser Phe Phe Leu 
1               5                   10                  15      


Thr Gly Val Ala Gly Thr Gln Ser Thr His Glu Ser Leu Lys Pro Gln 
            20                  25                  30          


Arg Val Gln Phe Gln Ser Arg Asn Phe His Asn Ile Leu Gln Trp Gln 
        35                  40                  45              


Pro Gly Arg Ala Leu Thr Gly Asn Ser Ser Val Tyr Phe Val Gln Tyr 
    50                  55                  60                  


Lys Ile Tyr Gly Gln Arg Gln Trp Lys Asn Lys Glu Asp Cys Trp Gly 
65                  70                  75                  80  


Thr Gln Glu Leu Ser Cys Asp Leu Thr Ser Glu Thr Ser Asp Ile Gln 
                85                  90                  95      


Glu Pro Tyr Tyr Gly Arg Val Arg Ala Ala Ser Ala Gly Ser Tyr Ser 
            100                 105                 110         


Glu Trp Ser Met Thr Pro Arg Phe Thr Pro Trp Trp Glu Arg Ala Lys 
        115                 120                 125             


Gly Leu 
    130 


<210>  7014
<211>  231
<212>  PRT
<213>  Homo Sapiens

<400>  7014

Met Met Pro Lys His Cys Phe Leu Gly Phe Leu Ile Ser Phe Phe Leu 
1               5                   10                  15      


Thr Gly Val Ala Gly Thr Gln Ser Thr His Glu Ser Leu Lys Pro Gln 
            20                  25                  30          


Arg Val Gln Phe Gln Ser Arg Asn Phe His Asn Ile Leu Gln Trp Gln 
        35                  40                  45              


Pro Gly Arg Ala Leu Thr Gly Asn Ser Ser Val Tyr Phe Val Gln Tyr 
    50                  55                  60                  


Lys Ile Tyr Gly Gln Arg Gln Trp Lys Asn Lys Glu Asp Cys Trp Gly 
65                  70                  75                  80  


Thr Gln Glu Leu Ser Cys Asp Leu Thr Ser Glu Thr Ser Asp Ile Gln 
                85                  90                  95      


Glu Pro Tyr Tyr Gly Arg Val Arg Ala Ala Ser Ala Gly Ser Tyr Ser 
            100                 105                 110         


Glu Trp Ser Met Thr Pro Arg Phe Thr Pro Trp Trp Glu Thr Lys Ile 
        115                 120                 125             


Asp Pro Pro Val Met Asn Ile Thr Gln Val Asn Gly Ser Leu Leu Val 
    130                 135                 140                 


Ile Leu His Ala Pro Asn Leu Pro Tyr Arg Tyr Gln Lys Glu Lys Asn 
145                 150                 155                 160 


Val Ser Ile Glu Asp Tyr Tyr Glu Leu Leu Tyr Arg Val Phe Ile Ile 
                165                 170                 175     


Asn Asn Ser Leu Glu Lys Glu Gln Lys Val Tyr Glu Gly Ala His Arg 
            180                 185                 190         


Ala Val Glu Ile Glu Ala Leu Thr Pro His Ser Ser Tyr Cys Val Val 
        195                 200                 205             


Ala Glu Ile Tyr Gln Pro Met Leu Asp Arg Arg Ser Gln Arg Ser Glu 
    210                 215                 220                 


Glu Arg Cys Val Glu Ile Pro 
225                 230     


<210>  7015
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  7015

Met Leu Gly Ser Arg Ala Val Met Leu Leu Leu Leu Leu Pro Trp Thr 
1               5                   10                  15      


Ala Gln Gly Arg Ala Val Pro Gly Gly Ser Ser Pro Ala Trp Thr Gln 
            20                  25                  30          


Cys Gln Gln Leu Ser Gln Lys Leu Cys Thr Leu Ala Trp Ser Ala His 
        35                  40                  45              


Pro Leu Val Gly His Met Asp Leu Arg Glu Glu Gly Asp Glu Glu Thr 
    50                  55                  60                  


Thr Asn Asp Val Pro His Ile Gln Cys Gly Asp Gly Cys Asp Pro Gln 
65                  70                  75                  80  


Gly Leu Arg Asp Asn Ser Gln Phe Cys Leu Gln Arg Ile His Gln Gly 
                85                  90                  95      


Leu Ile Phe Tyr Glu Lys Leu Leu Gly Ser Asp Ile Phe Thr Gly Glu 
            100                 105                 110         


Pro Ser Leu Leu Pro Asp Ser Pro Val Gly Gln Leu His Ala Ser Leu 
        115                 120                 125             


Leu Gly Leu Ser Gln Leu Leu Gln Pro Glu Gly His His Trp Glu Thr 
    130                 135                 140                 


Gln Gln Ile Pro Ser Leu Ser Pro Ser Gln Pro Trp Gln Arg Leu Leu 
145                 150                 155                 160 


Leu Arg Phe Lys Ile Leu Arg Ser Leu Gln Ala Phe Val Ala Val Ala 
                165                 170                 175     


Ala Arg Val Phe Ala His Gly Ala Ala Thr Leu Ser Pro 
            180                 185                 


<210>  7016
<211>  206
<212>  PRT
<213>  Homo Sapiens

<400>  7016

Met Asn Phe Gln Gln Arg Leu Gln Ser Leu Trp Thr Leu Ala Arg Pro 
1               5                   10                  15      


Phe Cys Pro Pro Leu Leu Ala Thr Ala Ser Gln Met Gln Met Val Val 
            20                  25                  30          


Leu Pro Cys Leu Gly Phe Thr Leu Leu Leu Trp Ser Gln Val Ser Gly 
        35                  40                  45              


Ala Gln Gly Gln Glu Phe His Phe Gly Pro Cys Gln Val Lys Gly Val 
    50                  55                  60                  


Val Pro Gln Lys Leu Trp Glu Ala Phe Trp Ala Val Lys Asp Thr Met 
65                  70                  75                  80  


Gln Ala Gln Asp Asn Ile Thr Ser Ala Arg Leu Leu Gln Gln Glu Val 
                85                  90                  95      


Leu Gln Asn Val Ser Asp Ala Glu Ser Cys Tyr Leu Val His Thr Leu 
            100                 105                 110         


Leu Glu Phe Tyr Leu Lys Thr Val Phe Lys Asn Tyr His Asn Arg Thr 
        115                 120                 125             


Val Glu Val Arg Thr Leu Lys Ser Phe Ser Thr Leu Ala Asn Asn Phe 
    130                 135                 140                 


Val Leu Ile Val Ser Gln Leu Gln Pro Ser Gln Glu Asn Glu Met Phe 
145                 150                 155                 160 


Ser Ile Arg Asp Ser Ala His Arg Arg Phe Leu Leu Phe Arg Arg Ala 
                165                 170                 175     


Phe Lys Gln Leu Asp Val Glu Ala Ala Leu Thr Lys Ala Leu Gly Glu 
            180                 185                 190         


Val Asp Ile Leu Leu Thr Trp Met Gln Lys Phe Tyr Lys Leu 
        195                 200                 205     


<210>  7017
<211>  60
<212>  PRT
<213>  Homo Sapiens

<400>  7017

Met Asn Phe Gln Gln Arg Leu Gln Ser Leu Trp Thr Leu Ala Ser Lys 
1               5                   10                  15      


Leu Arg Ile Thr Ser Arg Val Pro Gly Cys Cys Ser Arg Arg Phe Cys 
            20                  25                  30          


Arg Thr Ser Arg Lys Lys Met Arg Cys Phe Pro Ser Glu Thr Val His 
        35                  40                  45              


Thr Gly Gly Phe Cys Tyr Ser Gly Glu His Ser Asn 
    50                  55                  60  


<210>  7018
<211>  63
<212>  PRT
<213>  Homo Sapiens

<400>  7018

Met Asn Phe Gln Gln Arg Leu Gln Ser Leu Trp Thr Leu Ala Ser Lys 
1               5                   10                  15      


Leu Arg Ile Thr Ser Arg Val Pro Gly Cys Cys Ser Arg Arg Phe Cys 
            20                  25                  30          


Arg Thr Ser Arg Lys Lys Met Arg Cys Phe Pro Ser Glu Thr Val His 
        35                  40                  45              


Thr Gly Gly Phe Cys Tyr Ser Gly Glu His Ser Asn Ser Trp Thr 
    50                  55                  60              


<210>  7019
<211>  51
<212>  PRT
<213>  Homo Sapiens

<400>  7019

Met Asn Phe Gln Gln Arg Leu Gln Ser Leu Trp Thr Leu Ala Ser Lys 
1               5                   10                  15      


Leu Arg Ile Thr Ser Arg Val Pro Gly Cys Cys Ser Arg Arg Phe Cys 
            20                  25                  30          


Arg Thr Ser Arg Met Leu Arg Ala Val Thr Leu Ser Thr Pro Cys Trp 
        35                  40                  45              


Ser Ser Thr 
    50      


<210>  7020
<211>  207
<212>  PRT
<213>  Homo Sapiens

<400>  7020

Met Asn Phe Gln Gln Arg Leu Gln Ser Leu Trp Thr Leu Ala Ser Arg 
1               5                   10                  15      


Pro Phe Cys Pro Pro Leu Leu Ala Thr Ala Ser Gln Met Gln Met Val 
            20                  25                  30          


Val Leu Pro Cys Leu Gly Phe Thr Leu Leu Leu Trp Ser Gln Val Ser 
        35                  40                  45              


Gly Ala Gln Gly Gln Glu Phe His Phe Gly Pro Cys Gln Val Lys Gly 
    50                  55                  60                  


Val Val Pro Gln Lys Leu Trp Glu Ala Phe Trp Ala Val Lys Asp Thr 
65                  70                  75                  80  


Met Gln Ala Gln Asp Asn Ile Thr Ser Ala Arg Leu Leu Gln Gln Glu 
                85                  90                  95      


Val Leu Gln Asn Val Ser Asp Ala Glu Ser Cys Tyr Leu Val His Thr 
            100                 105                 110         


Leu Leu Glu Phe Tyr Leu Lys Thr Val Phe Lys Asn Tyr His Asn Arg 
        115                 120                 125             


Thr Val Glu Val Arg Thr Leu Lys Ser Phe Ser Thr Leu Ala Asn Asn 
    130                 135                 140                 


Phe Val Leu Ile Val Ser Gln Leu Gln Pro Ser Gln Glu Asn Glu Met 
145                 150                 155                 160 


Phe Ser Ile Arg Asp Ser Ala His Arg Arg Phe Leu Leu Phe Arg Arg 
                165                 170                 175     


Ala Phe Lys Gln Leu Asp Val Glu Ala Ala Leu Thr Lys Ala Leu Gly 
            180                 185                 190         


Glu Val Asp Ile Leu Leu Thr Trp Met Gln Lys Phe Tyr Lys Leu 
        195                 200                 205         


<210>  7021
<211>  154
<212>  PRT
<213>  Homo Sapiens

<400>  7021

Met Asn Phe Gln Gln Arg Leu Gln Ser Leu Trp Thr Leu Ala Ser Arg 
1               5                   10                  15      


Pro Phe Cys Pro Pro Leu Leu Ala Thr Ala Ser Gln Met Gln Met Val 
            20                  25                  30          


Val Leu Pro Cys Leu Gly Phe Thr Leu Leu Leu Trp Ser Gln Val Ser 
        35                  40                  45              


Gly Ala Gln Gly Gln Glu Phe His Phe Gly Pro Cys Gln Val Lys Gly 
    50                  55                  60                  


Val Val Pro Gln Lys Leu Trp Glu Ala Phe Trp Ala Val Lys Asp Thr 
65                  70                  75                  80  


Met Gln Ala Gln Asp Asn Ile Thr Ser Ala Arg Leu Leu Gln Gln Glu 
                85                  90                  95      


Val Leu Gln Asn Val Ser Gln Glu Asn Glu Met Phe Ser Ile Arg Asp 
            100                 105                 110         


Ser Ala His Arg Arg Phe Leu Leu Phe Arg Arg Ala Phe Lys Gln Leu 
        115                 120                 125             


Asp Val Glu Ala Ala Leu Thr Lys Ala Leu Gly Glu Val Asp Ile Leu 
    130                 135                 140                 


Leu Thr Trp Met Gln Lys Phe Tyr Lys Leu 
145                 150                 


<210>  7022
<211>  177
<212>  PRT
<213>  Homo Sapiens

<400>  7022

Met Arg Glu Arg Pro Arg Leu Gly Glu Asp Ser Ser Leu Ile Ser Leu 
1               5                   10                  15      


Phe Leu Gln Val Val Ala Phe Leu Ala Met Val Met Gly Thr His Thr 
            20                  25                  30          


Tyr Ser His Trp Pro Ser Cys Cys Pro Ser Lys Gly Gln Asp Thr Ser 
        35                  40                  45              


Glu Glu Leu Leu Arg Trp Ser Thr Val Pro Val Pro Pro Leu Glu Pro 
    50                  55                  60                  


Ala Arg Pro Asn Arg His Pro Glu Ser Cys Arg Ala Ser Glu Asp Gly 
65                  70                  75                  80  


Pro Leu Asn Ser Arg Ala Ile Ser Pro Trp Arg Tyr Glu Leu Asp Arg 
                85                  90                  95      


Asp Leu Asn Arg Leu Pro Gln Asp Leu Tyr His Ala Arg Cys Leu Cys 
            100                 105                 110         


Pro His Cys Val Ser Leu Gln Thr Gly Ser His Met Asp Pro Arg Gly 
        115                 120                 125             


Asn Ser Glu Leu Leu Tyr His Asn Gln Thr Val Phe Tyr Arg Arg Pro 
    130                 135                 140                 


Cys His Gly Glu Lys Gly Thr His Lys Gly Tyr Cys Leu Glu Arg Arg 
145                 150                 155                 160 


Leu Tyr Arg Val Ser Leu Ala Cys Val Cys Val Arg Pro Arg Val Met 
                165                 170                 175     


Gly 
    


<210>  7023
<211>  161
<212>  PRT
<213>  Homo Sapiens

<400>  7023

Met Tyr Gln Val Val Ala Phe Leu Ala Met Val Met Gly Thr His Thr 
1               5                   10                  15      


Tyr Ser His Trp Pro Ser Cys Cys Pro Ser Lys Gly Gln Asp Thr Ser 
            20                  25                  30          


Glu Glu Leu Leu Arg Trp Ser Thr Val Pro Val Pro Pro Leu Glu Pro 
        35                  40                  45              


Ala Arg Pro Asn Arg His Pro Glu Ser Cys Arg Ala Ser Glu Asp Gly 
    50                  55                  60                  


Pro Leu Asn Ser Arg Ala Ile Ser Pro Trp Arg Tyr Glu Leu Asp Arg 
65                  70                  75                  80  


Asp Leu Asn Arg Leu Pro Gln Asp Leu Tyr His Ala Arg Cys Leu Cys 
                85                  90                  95      


Pro His Cys Val Ser Leu Gln Thr Gly Ser His Met Asp Pro Arg Gly 
            100                 105                 110         


Asn Ser Glu Leu Leu Tyr His Asn Gln Thr Val Phe Tyr Arg Arg Pro 
        115                 120                 125             


Cys His Gly Glu Lys Gly Thr His Lys Gly Tyr Cys Leu Glu Arg Arg 
    130                 135                 140                 


Leu Tyr Arg Val Ser Leu Ala Cys Val Cys Val Arg Pro Arg Val Met 
145                 150                 155                 160 


Gly 
    


<210>  7024
<211>  171
<212>  PRT
<213>  Homo Sapiens

<400>  7024

Met Leu Val Asn Phe Ile Leu Arg Cys Gly Leu Leu Leu Val Thr Leu 
1               5                   10                  15      


Ser Leu Ala Ile Ala Lys His Lys Gln Ser Ser Phe Thr Lys Ser Cys 
            20                  25                  30          


Tyr Pro Arg Gly Thr Leu Ser Gln Ala Val Asp Ala Leu Tyr Ile Lys 
        35                  40                  45              


Ala Ala Trp Leu Lys Ala Thr Ile Pro Glu Asp Arg Ile Lys Asn Ile 
    50                  55                  60                  


Arg Leu Leu Lys Lys Lys Thr Lys Lys Gln Phe Met Lys Asn Cys Gln 
65                  70                  75                  80  


Phe Gln Glu Gln Leu Leu Ser Phe Phe Met Glu Asp Val Phe Gly Gln 
                85                  90                  95      


Leu Gln Leu Gln Gly Cys Lys Lys Ile Arg Phe Val Glu Asp Phe His 
            100                 105                 110         


Ser Leu Arg Gln Lys Leu Ser His Cys Ile Ser Cys Ala Ser Ser Ala 
        115                 120                 125             


Arg Glu Met Lys Ser Ile Thr Arg Met Lys Arg Ile Phe Tyr Arg Ile 
    130                 135                 140                 


Gly Asn Lys Gly Ile Tyr Lys Ala Ile Ser Glu Leu Asp Ile Leu Leu 
145                 150                 155                 160 


Ser Trp Ile Lys Lys Leu Leu Glu Ser Ser Gln 
                165                 170     


<210>  7025
<211>  24
<212>  PRT
<213>  Homo Sapiens

<400>  7025

Met Glu Arg Met Gln Leu Trp Ala Met Arg Leu Asp Leu Arg Asp Leu 
1               5                   10                  15      


Gln Arg His Leu Arg Phe Gln Val 
            20                  


<210>  7026
<211>  243
<212>  PRT
<213>  Homo Sapiens

<400>  7026

Met Gly Gln Thr Ala Gly Asp Leu Gly Trp Arg Leu Ser Leu Leu Leu 
1               5                   10                  15      


Leu Pro Leu Leu Leu Val Gln Ala Gly Val Trp Gly Phe Pro Arg Pro 
            20                  25                  30          


Pro Gly Arg Pro Gln Leu Ser Leu Gln Glu Leu Arg Arg Glu Phe Thr 
        35                  40                  45              


Val Ser Leu His Leu Ala Arg Lys Leu Leu Ser Glu Val Arg Gly Gln 
    50                  55                  60                  


Ala His Arg Phe Ala Glu Ser His Leu Pro Gly Val Asn Leu Tyr Leu 
65                  70                  75                  80  


Leu Pro Leu Gly Glu Gln Leu Pro Asp Val Ser Leu Thr Phe Gln Ala 
                85                  90                  95      


Trp Arg Arg Leu Ser Asp Pro Glu Arg Leu Cys Phe Ile Ser Thr Thr 
            100                 105                 110         


Leu Gln Pro Phe His Ala Leu Leu Gly Gly Leu Gly Thr Gln Gly Arg 
        115                 120                 125             


Trp Thr Asn Met Glu Arg Met Gln Leu Trp Ala Met Arg Leu Asp Leu 
    130                 135                 140                 


Arg Asp Leu Gln Arg His Leu Arg Phe Gln Val Leu Ala Ala Gly Phe 
145                 150                 155                 160 


Asn Leu Pro Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
                165                 170                 175     


Arg Lys Gly Leu Leu Pro Gly Ala Leu Gly Ser Ala Leu Gln Gly Pro 
            180                 185                 190         


Ala Gln Val Ser Trp Pro Gln Leu Leu Ser Thr Tyr Arg Leu Leu His 
        195                 200                 205             


Ser Leu Glu Leu Val Leu Ser Arg Ala Val Arg Glu Leu Leu Leu Leu 
    210                 215                 220                 


Ser Lys Ala Gly His Ser Val Trp Pro Leu Gly Phe Pro Thr Leu Ser 
225                 230                 235                 240 


Pro Gln Pro 
            


<210>  7027
<211>  88
<212>  PRT
<213>  Homo Sapiens

<400>  7027

Met Ala Ala Pro Ala Leu Ser Trp Arg Leu Pro Leu Leu Ile Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ala Thr Ser Trp Ala Ser Ala Ala Val Asn Gly Thr Ser 
            20                  25                  30          


Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp 
        35                  40                  45              


Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp 
    50                  55                  60                  


Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser 
65                  70                  75                  80  


Gln Ala Ser Trp Ala Cys Asn Leu 
                85              


<210>  7028
<211>  146
<212>  PRT
<213>  Homo Sapiens

<400>  7028

Met Ala Ala Pro Ala Leu Ser Trp Arg Leu Pro Leu Leu Ile Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ala Thr Ser Trp Ala Ser Ala Ala Val Asn Gly Thr Ser 
            20                  25                  30          


Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp 
        35                  40                  45              


Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp 
    50                  55                  60                  


Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser 
65                  70                  75                  80  


Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln 
                85                  90                  95      


Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu 
            100                 105                 110         


Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu 
        115                 120                 125             


Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu 
    130                 135                 140                 


Thr His 
145     


<210>  7029
<211>  188
<212>  PRT
<213>  Homo Sapiens

<400>  7029

Met Ala Ala Pro Ala Leu Ser Trp Arg Leu Pro Leu Leu Ile Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ala Thr Ser Trp Ala Ser Ala Ala Val Asn Gly Thr Ser 
            20                  25                  30          


Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp 
        35                  40                  45              


Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp 
    50                  55                  60                  


Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser 
65                  70                  75                  80  


Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln 
                85                  90                  95      


Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu 
            100                 105                 110         


Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu 
        115                 120                 125             


Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu 
    130                 135                 140                 


Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr 
145                 150                 155                 160 


Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His 
                165                 170                 175     


Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln 
            180                 185             


<210>  7030
<211>  551
<212>  PRT
<213>  Homo Sapiens

<400>  7030

Met Ala Ala Pro Ala Leu Ser Trp Arg Leu Pro Leu Leu Ile Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ala Thr Ser Trp Ala Ser Ala Ala Val Asn Gly Thr Ser 
            20                  25                  30          


Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp 
        35                  40                  45              


Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp 
    50                  55                  60                  


Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser 
65                  70                  75                  80  


Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln 
                85                  90                  95      


Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu 
            100                 105                 110         


Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu 
        115                 120                 125             


Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu 
    130                 135                 140                 


Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr 
145                 150                 155                 160 


Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His 
                165                 170                 175     


Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp 
            180                 185                 190         


Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val 
        195                 200                 205             


Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser 
    210                 215                 220                 


Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp Thr 
225                 230                 235                 240 


Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly 
                245                 250                 255     


Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly Pro 
            260                 265                 270         


Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe 
        275                 280                 285             


Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu 
    290                 295                 300                 


Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro 
305                 310                 315                 320 


Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu 
                325                 330                 335     


Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn 
            340                 345                 350         


His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His 
        355                 360                 365             


Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr Phe Thr Tyr 
    370                 375                 380                 


Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala Gly Ala Pro 
385                 390                 395                 400 


Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp 
                405                 410                 415     


Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro 
            420                 425                 430         


Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly Ser 
        435                 440                 445             


Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val Pro 
    450                 455                 460                 


Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val Pro 
465                 470                 475                 480 


Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu Ala 
                485                 490                 495     


Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe Pro 
            500                 505                 510         


Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg 
        515                 520                 525             


Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly 
    530                 535                 540                 


Gln Asp Pro Thr His Leu Val 
545                 550     


<210>  7031
<211>  105
<212>  PRT
<213>  Homo Sapiens

<400>  7031

Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp Ser Gln 
1               5                   10                  15      


Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp Pro Asp 
            20                  25                  30          


Arg Arg Ser Leu Gln Leu Pro Trp Asp Gln Ala Gly Met Arg Glu Gln 
        35                  40                  45              


Asp Lys Val Pro Met Arg Glu Glu Cys His Gly Ala Ser Gly Gly Gly 
    50                  55                  60                  


Ser Ala Pro His Ser Gly Trp His Arg Gly Pro Ser Leu Ala Leu Leu 
65                  70                  75                  80  


Pro Gly Ala Ile Leu Ala Ala Glu Arg Ser Glu Lys Ser Pro Leu Gly 
                85                  90                  95      


Gln Leu Cys Gly Ser Phe Leu Phe Phe 
            100                 105 


<210>  7032
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  7032

Met Ser Arg Leu Pro Val Leu Leu Leu Leu Gln Leu Leu Val Arg Pro 
1               5                   10                  15      


Gly Leu Gln Ala Pro Met Thr Gln Thr Thr Pro Leu Lys Thr Ser Trp 
            20                  25                  30          


Val Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln 
        35                  40                  45              


Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln 
    50                  55                  60                  


Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe 
65                  70                  75                  80  


Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile 
                85                  90                  95      


Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr 
            100                 105                 110         


Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg 
        115                 120                 125             


Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln 
    130                 135                 140                 


Thr Thr Leu Ser Leu Ala Ile Phe 
145                 150         


<210>  7033
<211>  164
<212>  PRT
<213>  Homo Sapiens

<400>  7033

Met Ala Ser His Ser Gly Pro Ser Thr Ser Val Leu Phe Leu Phe Cys 
1               5                   10                  15      


Cys Leu Gly Gly Trp Leu Ala Ser His Thr Leu Pro Val Arg Leu Leu 
            20                  25                  30          


Arg Pro Ser Asp Asp Val Gln Lys Ile Val Glu Glu Leu Gln Ser Leu 
        35                  40                  45              


Ser Lys Met Leu Leu Lys Asp Val Glu Glu Glu Lys Gly Val Leu Val 
    50                  55                  60                  


Ser Gln Asn Tyr Thr Leu Pro Cys Leu Ser Pro Asp Ala Gln Pro Pro 
65                  70                  75                  80  


Asn Asn Ile His Ser Pro Ala Ile Arg Ala Tyr Leu Lys Thr Ile Arg 
                85                  90                  95      


Gln Leu Asp Asn Lys Ser Val Ile Asp Glu Ile Ile Glu His Leu Asp 
            100                 105                 110         


Lys Leu Ile Phe Gln Asp Ala Pro Glu Thr Asn Ile Ser Val Pro Thr 
        115                 120                 125             


Asp Thr His Glu Cys Lys Arg Phe Ile Leu Thr Ile Ser Gln Gln Phe 
    130                 135                 140                 


Ser Glu Cys Met Asp Leu Ala Leu Lys Ser Leu Thr Ser Gly Ala Gln 
145                 150                 155                 160 


Gln Ala Thr Thr 
                


<210>  7034
<211>  582
<212>  PRT
<213>  Homo Sapiens

<400>  7034

Met Cys Ile Arg Gln Leu Lys Phe Phe Thr Thr Ala Cys Val Cys Glu 
1               5                   10                  15      


Cys Pro Gln Asn Ile Leu Ser Pro Gln Pro Ser Cys Val Asn Leu Gly 
            20                  25                  30          


Met Met Trp Thr Trp Ala Leu Trp Met Leu Pro Ser Leu Cys Lys Phe 
        35                  40                  45              


Ser Leu Ala Ala Leu Pro Ala Lys Pro Glu Asn Ile Ser Cys Val Tyr 
    50                  55                  60                  


Tyr Tyr Arg Lys Asn Leu Thr Cys Thr Trp Ser Pro Gly Lys Glu Thr 
65                  70                  75                  80  


Ser Tyr Thr Gln Tyr Thr Val Lys Arg Thr Tyr Ala Phe Gly Glu Lys 
                85                  90                  95      


His Asp Asn Cys Thr Thr Asn Ser Ser Thr Ser Glu Asn Arg Ala Ser 
            100                 105                 110         


Cys Ser Phe Phe Leu Pro Arg Ile Thr Ile Pro Asp Asn Tyr Thr Ile 
        115                 120                 125             


Glu Val Glu Ala Glu Asn Gly Asp Gly Val Ile Lys Ser His Met Thr 
    130                 135                 140                 


Tyr Trp Arg Leu Glu Asn Ile Ala Lys Thr Glu Pro Pro Lys Ile Phe 
145                 150                 155                 160 


Arg Val Lys Pro Val Leu Gly Ile Lys Arg Met Ile Gln Ile Glu Trp 
                165                 170                 175     


Ile Lys Pro Glu Leu Ala Pro Val Ser Ser Asp Leu Lys Tyr Thr Leu 
            180                 185                 190         


Arg Phe Arg Thr Val Asn Ser Thr Ser Trp Met Glu Val Asn Phe Ala 
        195                 200                 205             


Lys Asn Arg Lys Asp Lys Asn Gln Thr Tyr Asn Leu Thr Gly Leu Gln 
    210                 215                 220                 


Pro Phe Thr Glu Tyr Val Ile Ala Leu Arg Cys Ala Val Lys Glu Ser 
225                 230                 235                 240 


Lys Phe Trp Ser Asp Trp Ser Gln Glu Lys Met Gly Met Thr Glu Glu 
                245                 250                 255     


Glu Ala Pro Cys Gly Leu Glu Leu Trp Arg Val Leu Lys Pro Ala Glu 
            260                 265                 270         


Ala Asp Gly Arg Arg Pro Val Arg Leu Leu Trp Lys Lys Ala Arg Gly 
        275                 280                 285             


Ala Pro Val Leu Glu Lys Thr Leu Gly Tyr Asn Ile Trp Tyr Tyr Pro 
    290                 295                 300                 


Glu Ser Asn Thr Asn Leu Thr Glu Thr Met Asn Thr Thr Asn Gln Gln 
305                 310                 315                 320 


Leu Glu Leu His Leu Gly Gly Glu Ser Phe Trp Val Ser Met Ile Ser 
                325                 330                 335     


Tyr Asn Ser Leu Gly Lys Ser Pro Val Ala Thr Leu Arg Ile Pro Ala 
            340                 345                 350         


Ile Gln Glu Lys Ser Phe Gln Cys Ile Glu Val Met Gln Ala Cys Val 
        355                 360                 365             


Ala Glu Asp Gln Leu Val Val Lys Trp Gln Ser Ser Ala Leu Asp Val 
    370                 375                 380                 


Asn Thr Trp Met Ile Glu Trp Phe Pro Asp Val Asp Ser Glu Pro Thr 
385                 390                 395                 400 


Thr Leu Ser Trp Glu Ser Val Ser Gln Ala Thr Asn Trp Thr Ile Gln 
                405                 410                 415     


Gln Asp Lys Leu Lys Pro Phe Trp Cys Tyr Asn Ile Ser Val Tyr Pro 
            420                 425                 430         


Met Leu His Asp Lys Val Gly Glu Pro Tyr Ser Ile Gln Ala Tyr Ala 
        435                 440                 445             


Lys Glu Gly Val Pro Ser Glu Gly Pro Glu Thr Lys Val Glu Asn Ile 
    450                 455                 460                 


Gly Val Lys Thr Val Thr Ile Thr Trp Lys Glu Ile Pro Lys Ser Glu 
465                 470                 475                 480 


Arg Lys Gly Ile Ile Cys Asn Tyr Thr Ile Phe Tyr Gln Ala Glu Gly 
                485                 490                 495     


Gly Lys Gly Phe Cys Lys His Ala His Ser Glu Val Glu Lys Asn Pro 
            500                 505                 510         


Lys Pro Gln Ile Asp Ala Met Asp Arg Pro Val Val Gly Met Ala Pro 
        515                 520                 525             


Pro Ser His Cys Asp Leu Gln Pro Gly Met Asn His Leu Ala Ser Leu 
    530                 535                 540                 


Asn Leu Ser Glu Asn Gly Ala Lys Ser Thr His Leu Leu Gly Phe Trp 
545                 550                 555                 560 


Gly Leu Asn Glu Ser Glu Val Thr Val Pro Glu Arg Arg Val Leu Arg 
                565                 570                 575     


Lys Trp Lys Glu Leu Leu 
            580         


<210>  7035
<211>  681
<212>  PRT
<213>  Homo Sapiens

<400>  7035

Met Cys Ile Arg Gln Leu Lys Phe Phe Thr Thr Ala Cys Val Cys Glu 
1               5                   10                  15      


Cys Pro Gln Asn Ile Leu Ser Pro Gln Pro Ser Cys Val Asn Leu Gly 
            20                  25                  30          


Met Met Trp Thr Trp Ala Leu Trp Met Leu Pro Ser Leu Cys Lys Phe 
        35                  40                  45              


Ser Leu Ala Ala Leu Pro Ala Lys Pro Glu Asn Ile Ser Cys Val Tyr 
    50                  55                  60                  


Tyr Tyr Arg Lys Asn Leu Thr Cys Thr Trp Ser Pro Gly Lys Glu Thr 
65                  70                  75                  80  


Ser Tyr Thr Gln Tyr Thr Val Lys Arg Thr Tyr Ala Phe Gly Glu Lys 
                85                  90                  95      


His Asp Asn Cys Thr Thr Asn Ser Ser Thr Ser Glu Asn Arg Ala Ser 
            100                 105                 110         


Cys Ser Phe Phe Leu Pro Arg Ile Thr Ile Pro Asp Asn Tyr Thr Ile 
        115                 120                 125             


Glu Val Glu Ala Glu Asn Gly Asp Gly Val Ile Lys Ser His Met Thr 
    130                 135                 140                 


Tyr Trp Arg Leu Glu Asn Ile Ala Lys Thr Glu Pro Pro Lys Ile Phe 
145                 150                 155                 160 


Arg Val Lys Pro Val Leu Gly Ile Lys Arg Met Ile Gln Ile Glu Trp 
                165                 170                 175     


Ile Lys Pro Glu Leu Ala Pro Val Ser Ser Asp Leu Lys Tyr Thr Leu 
            180                 185                 190         


Arg Phe Arg Thr Val Asn Ser Thr Ser Trp Met Glu Val Asn Phe Ala 
        195                 200                 205             


Lys Asn Arg Lys Asp Lys Asn Gln Thr Tyr Asn Leu Thr Gly Leu Gln 
    210                 215                 220                 


Pro Phe Thr Glu Tyr Val Ile Ala Leu Arg Cys Ala Val Lys Glu Ser 
225                 230                 235                 240 


Lys Phe Trp Ser Asp Trp Ser Gln Glu Lys Met Gly Met Thr Glu Glu 
                245                 250                 255     


Glu Ala Pro Cys Gly Leu Glu Leu Trp Arg Val Leu Lys Pro Ala Glu 
            260                 265                 270         


Ala Asp Gly Arg Arg Pro Val Arg Leu Leu Trp Lys Lys Ala Arg Gly 
        275                 280                 285             


Ala Pro Val Leu Glu Lys Thr Leu Gly Tyr Asn Ile Trp Tyr Tyr Pro 
    290                 295                 300                 


Glu Ser Asn Thr Asn Leu Thr Glu Thr Met Asn Thr Thr Asn Gln Gln 
305                 310                 315                 320 


Leu Glu Leu His Leu Gly Gly Glu Ser Phe Trp Val Ser Met Ile Ser 
                325                 330                 335     


Tyr Asn Ser Leu Gly Lys Ser Pro Val Ala Thr Leu Arg Ile Pro Ala 
            340                 345                 350         


Ile Gln Glu Lys Ser Phe Gln Cys Ile Glu Val Met Gln Ala Cys Val 
        355                 360                 365             


Ala Glu Asp Gln Leu Val Val Lys Trp Gln Ser Ser Ala Leu Asp Val 
    370                 375                 380                 


Asn Thr Trp Met Ile Glu Trp Phe Pro Asp Val Asp Ser Glu Pro Thr 
385                 390                 395                 400 


Thr Leu Ser Trp Glu Ser Val Ser Gln Ala Thr Asn Trp Thr Ile Gln 
                405                 410                 415     


Gln Asp Lys Leu Lys Pro Phe Trp Cys Tyr Asn Ile Ser Val Tyr Pro 
            420                 425                 430         


Met Leu His Asp Lys Val Gly Glu Pro Tyr Ser Ile Gln Ala Tyr Ala 
        435                 440                 445             


Lys Glu Gly Val Pro Ser Glu Gly Pro Glu Thr Lys Val Glu Asn Ile 
    450                 455                 460                 


Gly Val Lys Thr Val Thr Ile Thr Trp Lys Glu Ile Pro Lys Ser Glu 
465                 470                 475                 480 


Arg Lys Gly Ile Ile Cys Asn Tyr Thr Ile Phe Tyr Gln Ala Glu Gly 
                485                 490                 495     


Gly Lys Gly Phe Ser Lys Thr Val Asn Ser Ser Ile Leu Gln Tyr Gly 
            500                 505                 510         


Leu Glu Ser Leu Lys Arg Lys Thr Ser Tyr Ile Val Gln Val Met Ala 
        515                 520                 525             


Ser Thr Ser Ala Gly Gly Thr Asn Gly Thr Ser Ile Asn Phe Lys Thr 
    530                 535                 540                 


Leu Ser Phe Ser Val Phe Glu Ile Ile Leu Ile Thr Ser Leu Ile Gly 
545                 550                 555                 560 


Gly Gly Leu Leu Ile Leu Ile Ile Leu Thr Val Ala Tyr Gly Leu Lys 
                565                 570                 575     


Lys Pro Asn Lys Leu Thr His Leu Cys Trp Pro Thr Val Pro Asn Pro 
            580                 585                 590         


Ala Glu Ser Ser Ile Ala Thr Trp His Gly Asp Asp Phe Lys Asp Lys 
        595                 600                 605             


Leu Asn Leu Lys Glu Ser Asp Asp Ser Val Asn Thr Glu Asp Arg Ile 
    610                 615                 620                 


Leu Lys Pro Cys Ser Thr Pro Ser Asp Lys Leu Val Ile Asp Lys Leu 
625                 630                 635                 640 


Val Val Asn Phe Gly Asn Val Leu Gln Glu Ile Phe Thr Asp Glu Ala 
                645                 650                 655     


Arg Thr Gly Gln Glu Asn Asn Leu Gly Gly Glu Lys Asn Gly Thr Arg 
            660                 665                 670         


Ile Leu Ser Ser Cys Pro Thr Ser Ile 
        675                 680     


<210>  7036
<211>  764
<212>  PRT
<213>  Homo Sapiens

<400>  7036

Met Cys Ile Arg Gln Leu Lys Phe Phe Thr Thr Ala Cys Val Cys Glu 
1               5                   10                  15      


Cys Pro Gln Asn Ile Leu Ser Pro Gln Pro Ser Cys Val Asn Leu Gly 
            20                  25                  30          


Met Met Trp Thr Trp Ala Leu Trp Met Leu Pro Ser Leu Cys Lys Phe 
        35                  40                  45              


Ser Leu Ala Ala Leu Pro Ala Lys Pro Glu Asn Ile Ser Cys Val Tyr 
    50                  55                  60                  


Tyr Tyr Arg Lys Asn Leu Thr Cys Thr Trp Ser Pro Gly Lys Glu Thr 
65                  70                  75                  80  


Ser Tyr Thr Gln Tyr Thr Val Lys Arg Thr Tyr Ala Phe Gly Glu Lys 
                85                  90                  95      


His Asp Asn Cys Thr Thr Asn Ser Ser Thr Ser Glu Asn Arg Ala Ser 
            100                 105                 110         


Cys Ser Phe Phe Leu Pro Arg Ile Thr Ile Pro Asp Asn Tyr Thr Ile 
        115                 120                 125             


Glu Val Glu Ala Glu Asn Gly Asp Gly Val Ile Lys Ser His Met Thr 
    130                 135                 140                 


Tyr Trp Arg Leu Glu Asn Ile Ala Lys Thr Glu Pro Pro Lys Ile Phe 
145                 150                 155                 160 


Arg Val Lys Pro Val Leu Gly Ile Lys Arg Met Ile Gln Ile Glu Trp 
                165                 170                 175     


Ile Lys Pro Glu Leu Ala Pro Val Ser Ser Asp Leu Lys Tyr Thr Leu 
            180                 185                 190         


Arg Phe Arg Thr Val Asn Ser Thr Ser Trp Met Glu Val Asn Phe Ala 
        195                 200                 205             


Lys Asn Arg Lys Asp Lys Asn Gln Thr Tyr Asn Leu Thr Gly Leu Gln 
    210                 215                 220                 


Pro Phe Thr Glu Tyr Val Ile Ala Leu Arg Cys Ala Val Lys Glu Ser 
225                 230                 235                 240 


Lys Phe Trp Ser Asp Trp Ser Gln Glu Lys Met Gly Met Thr Glu Glu 
                245                 250                 255     


Glu Ala Pro Cys Gly Leu Glu Leu Trp Arg Val Leu Lys Pro Ala Glu 
            260                 265                 270         


Ala Asp Gly Arg Arg Pro Val Arg Leu Leu Trp Lys Lys Ala Arg Gly 
        275                 280                 285             


Ala Pro Val Leu Glu Lys Thr Leu Gly Tyr Asn Ile Trp Tyr Tyr Pro 
    290                 295                 300                 


Glu Ser Asn Thr Asn Leu Thr Glu Thr Met Asn Thr Thr Asn Gln Gln 
305                 310                 315                 320 


Leu Glu Leu His Leu Gly Gly Glu Ser Phe Trp Val Ser Met Ile Ser 
                325                 330                 335     


Tyr Asn Ser Leu Gly Lys Ser Pro Val Ala Thr Leu Arg Ile Pro Ala 
            340                 345                 350         


Ile Gln Glu Lys Ser Phe Gln Cys Ile Glu Val Met Gln Ala Cys Val 
        355                 360                 365             


Ala Glu Asp Gln Leu Val Val Lys Trp Gln Ser Ser Ala Leu Asp Val 
    370                 375                 380                 


Asn Thr Trp Met Ile Glu Trp Phe Pro Asp Val Asp Ser Glu Pro Thr 
385                 390                 395                 400 


Thr Leu Ser Trp Glu Ser Val Ser Gln Ala Thr Asn Trp Thr Ile Gln 
                405                 410                 415     


Gln Asp Lys Leu Lys Pro Phe Trp Cys Tyr Asn Ile Ser Val Tyr Pro 
            420                 425                 430         


Met Leu His Asp Lys Val Gly Glu Pro Tyr Ser Ile Gln Ala Tyr Ala 
        435                 440                 445             


Lys Glu Gly Val Pro Ser Glu Gly Pro Glu Thr Lys Val Glu Asn Ile 
    450                 455                 460                 


Gly Val Lys Thr Val Thr Ile Thr Trp Lys Glu Ile Pro Lys Ser Glu 
465                 470                 475                 480 


Arg Lys Gly Ile Ile Cys Asn Tyr Thr Ile Phe Tyr Gln Ala Glu Gly 
                485                 490                 495     


Gly Lys Gly Phe Ser Lys Thr Val Asn Ser Ser Ile Leu Gln Tyr Gly 
            500                 505                 510         


Leu Glu Ser Leu Lys Arg Lys Thr Ser Tyr Ile Val Gln Val Met Ala 
        515                 520                 525             


Ser Thr Ser Ala Gly Gly Thr Asn Gly Thr Ser Ile Asn Phe Lys Thr 
    530                 535                 540                 


Leu Ser Phe Ser Val Phe Glu Ile Ile Leu Ile Thr Ser Leu Ile Gly 
545                 550                 555                 560 


Gly Gly Leu Leu Ile Leu Ile Ile Leu Thr Val Ala Tyr Gly Leu Lys 
                565                 570                 575     


Lys Pro Asn Lys Leu Thr His Leu Cys Trp Pro Thr Val Pro Asn Pro 
            580                 585                 590         


Ala Glu Ser Ser Ile Ala Thr Trp His Gly Asp Asp Phe Lys Asp Lys 
        595                 600                 605             


Leu Asn Leu Lys Glu Ser Asp Asp Ser Val Asn Thr Glu Asp Arg Ile 
    610                 615                 620                 


Leu Lys Pro Cys Ser Thr Pro Ser Asp Lys Leu Val Ile Asp Lys Leu 
625                 630                 635                 640 


Val Val Asn Phe Gly Asn Val Leu Gln Glu Ile Phe Thr Asp Glu Ala 
                645                 650                 655     


Arg Thr Gly Gln Glu Asn Asn Leu Gly Gly Glu Lys Asn Gly Tyr Val 
            660                 665                 670         


Thr Cys Pro Phe Arg Pro Asp Cys Pro Leu Gly Lys Ser Phe Glu Glu 
        675                 680                 685             


Leu Pro Val Ser Pro Glu Ile Pro Pro Arg Lys Ser Gln Tyr Leu Arg 
    690                 695                 700                 


Ser Arg Met Pro Glu Gly Thr Arg Pro Glu Ala Lys Glu Gln Leu Leu 
705                 710                 715                 720 


Phe Ser Gly Gln Ser Leu Val Pro Asp His Leu Cys Glu Glu Gly Ala 
                725                 730                 735     


Pro Asn Pro Tyr Leu Lys Asn Ser Val Thr Ala Arg Glu Phe Leu Val 
            740                 745                 750         


Ser Glu Lys Leu Pro Glu His Thr Lys Gly Glu Val 
        755                 760                 


<210>  7037
<211>  745
<212>  PRT
<213>  Homo Sapiens

<400>  7037

Met Lys Leu Ser Pro Gln Pro Ser Cys Val Asn Leu Gly Met Met Trp 
1               5                   10                  15      


Thr Trp Ala Leu Trp Met Leu Pro Ser Leu Cys Lys Phe Ser Leu Ala 
            20                  25                  30          


Ala Leu Pro Ala Lys Pro Glu Asn Ile Ser Cys Val Tyr Tyr Tyr Arg 
        35                  40                  45              


Lys Asn Leu Thr Cys Thr Trp Ser Pro Gly Lys Glu Thr Ser Tyr Thr 
    50                  55                  60                  


Gln Tyr Thr Val Lys Arg Thr Tyr Ala Phe Gly Glu Lys His Asp Asn 
65                  70                  75                  80  


Cys Thr Thr Asn Ser Ser Thr Ser Glu Asn Arg Ala Ser Cys Ser Phe 
                85                  90                  95      


Phe Leu Pro Arg Ile Thr Ile Pro Asp Asn Tyr Thr Ile Glu Val Glu 
            100                 105                 110         


Ala Glu Asn Gly Asp Gly Val Ile Lys Ser His Met Thr Tyr Trp Arg 
        115                 120                 125             


Leu Glu Asn Ile Ala Lys Thr Glu Pro Pro Lys Ile Phe Arg Val Lys 
    130                 135                 140                 


Pro Val Leu Gly Ile Lys Arg Met Ile Gln Ile Glu Trp Ile Lys Pro 
145                 150                 155                 160 


Glu Leu Ala Pro Val Ser Ser Asp Leu Lys Tyr Thr Leu Arg Phe Arg 
                165                 170                 175     


Thr Val Asn Ser Thr Ser Trp Met Glu Val Asn Phe Ala Lys Asn Arg 
            180                 185                 190         


Lys Asp Lys Asn Gln Thr Tyr Asn Leu Thr Gly Leu Gln Pro Phe Thr 
        195                 200                 205             


Glu Tyr Val Ile Ala Leu Arg Cys Ala Val Lys Glu Ser Lys Phe Trp 
    210                 215                 220                 


Ser Asp Trp Ser Gln Glu Lys Met Gly Met Thr Glu Glu Glu Ala Pro 
225                 230                 235                 240 


Cys Gly Leu Glu Leu Trp Arg Val Leu Lys Pro Ala Glu Ala Asp Gly 
                245                 250                 255     


Arg Arg Pro Val Arg Leu Leu Trp Lys Lys Ala Arg Gly Ala Pro Val 
            260                 265                 270         


Leu Glu Lys Thr Leu Gly Tyr Asn Ile Trp Tyr Tyr Pro Glu Ser Asn 
        275                 280                 285             


Thr Asn Leu Thr Glu Thr Met Asn Thr Thr Asn Gln Gln Leu Glu Leu 
    290                 295                 300                 


His Leu Gly Gly Glu Ser Phe Trp Val Ser Met Ile Ser Tyr Asn Ser 
305                 310                 315                 320 


Leu Gly Lys Ser Pro Val Ala Thr Leu Arg Ile Pro Ala Ile Gln Glu 
                325                 330                 335     


Lys Ser Phe Gln Cys Ile Glu Val Met Gln Ala Cys Val Ala Glu Asp 
            340                 345                 350         


Gln Leu Val Val Lys Trp Gln Ser Ser Ala Leu Asp Val Asn Thr Trp 
        355                 360                 365             


Met Ile Glu Trp Phe Pro Asp Val Asp Ser Glu Pro Thr Thr Leu Ser 
    370                 375                 380                 


Trp Glu Ser Val Ser Gln Ala Thr Asn Trp Thr Ile Gln Gln Asp Lys 
385                 390                 395                 400 


Leu Lys Pro Phe Trp Cys Tyr Asn Ile Ser Val Tyr Pro Met Leu His 
                405                 410                 415     


Asp Lys Val Gly Glu Pro Tyr Ser Ile Gln Ala Tyr Ala Lys Glu Gly 
            420                 425                 430         


Val Pro Ser Glu Gly Pro Glu Thr Lys Val Glu Asn Ile Gly Val Lys 
        435                 440                 445             


Thr Val Thr Ile Thr Trp Lys Glu Ile Pro Lys Ser Glu Arg Lys Gly 
    450                 455                 460                 


Ile Ile Cys Asn Tyr Thr Ile Phe Tyr Gln Ala Glu Gly Gly Lys Gly 
465                 470                 475                 480 


Phe Ser Lys Thr Val Asn Ser Ser Ile Leu Gln Tyr Gly Leu Glu Ser 
                485                 490                 495     


Leu Lys Arg Lys Thr Ser Tyr Ile Val Gln Val Met Ala Ser Thr Ser 
            500                 505                 510         


Ala Gly Gly Thr Asn Gly Thr Ser Ile Asn Phe Lys Thr Leu Ser Phe 
        515                 520                 525             


Ser Val Phe Glu Ile Ile Leu Ile Thr Ser Leu Ile Gly Gly Gly Leu 
    530                 535                 540                 


Leu Ile Leu Ile Ile Leu Thr Val Ala Tyr Gly Leu Lys Lys Pro Asn 
545                 550                 555                 560 


Lys Leu Thr His Leu Cys Trp Pro Thr Val Pro Asn Pro Ala Glu Ser 
                565                 570                 575     


Ser Ile Ala Thr Trp His Gly Asp Asp Phe Lys Asp Lys Leu Asn Leu 
            580                 585                 590         


Lys Glu Ser Asp Asp Ser Val Asn Thr Glu Asp Arg Ile Leu Lys Pro 
        595                 600                 605             


Cys Ser Thr Pro Ser Asp Lys Leu Val Ile Asp Lys Leu Val Val Asn 
    610                 615                 620                 


Phe Gly Asn Val Leu Gln Glu Ile Phe Thr Asp Glu Ala Arg Thr Gly 
625                 630                 635                 640 


Gln Glu Asn Asn Leu Gly Gly Glu Lys Asn Gly Tyr Val Thr Cys Pro 
                645                 650                 655     


Phe Arg Pro Asp Cys Pro Leu Gly Lys Ser Phe Glu Glu Leu Pro Val 
            660                 665                 670         


Ser Pro Glu Ile Pro Pro Arg Lys Ser Gln Tyr Leu Arg Ser Arg Met 
        675                 680                 685             


Pro Glu Gly Thr Arg Pro Glu Ala Lys Glu Gln Leu Leu Phe Ser Gly 
    690                 695                 700                 


Gln Ser Leu Val Pro Asp His Leu Cys Glu Glu Gly Ala Pro Asn Pro 
705                 710                 715                 720 


Tyr Leu Lys Asn Ser Val Thr Ala Arg Glu Phe Leu Val Ser Glu Lys 
                725                 730                 735     


Leu Pro Glu His Thr Lys Gly Glu Val 
            740                 745 


<210>  7038
<211>  662
<212>  PRT
<213>  Homo Sapiens

<400>  7038

Met Lys Leu Ser Pro Gln Pro Ser Cys Val Asn Leu Gly Met Met Trp 
1               5                   10                  15      


Thr Trp Ala Leu Trp Met Leu Pro Ser Leu Cys Lys Phe Ser Leu Ala 
            20                  25                  30          


Ala Leu Pro Ala Lys Pro Glu Asn Ile Ser Cys Val Tyr Tyr Tyr Arg 
        35                  40                  45              


Lys Asn Leu Thr Cys Thr Trp Ser Pro Gly Lys Glu Thr Ser Tyr Thr 
    50                  55                  60                  


Gln Tyr Thr Val Lys Arg Thr Tyr Ala Phe Gly Glu Lys His Asp Asn 
65                  70                  75                  80  


Cys Thr Thr Asn Ser Ser Thr Ser Glu Asn Arg Ala Ser Cys Ser Phe 
                85                  90                  95      


Phe Leu Pro Arg Ile Thr Ile Pro Asp Asn Tyr Thr Ile Glu Val Glu 
            100                 105                 110         


Ala Glu Asn Gly Asp Gly Val Ile Lys Ser His Met Thr Tyr Trp Arg 
        115                 120                 125             


Leu Glu Asn Ile Ala Lys Thr Glu Pro Pro Lys Ile Phe Arg Val Lys 
    130                 135                 140                 


Pro Val Leu Gly Ile Lys Arg Met Ile Gln Ile Glu Trp Ile Lys Pro 
145                 150                 155                 160 


Glu Leu Ala Pro Val Ser Ser Asp Leu Lys Tyr Thr Leu Arg Phe Arg 
                165                 170                 175     


Thr Val Asn Ser Thr Ser Trp Met Glu Val Asn Phe Ala Lys Asn Arg 
            180                 185                 190         


Lys Asp Lys Asn Gln Thr Tyr Asn Leu Thr Gly Leu Gln Pro Phe Thr 
        195                 200                 205             


Glu Tyr Val Ile Ala Leu Arg Cys Ala Val Lys Glu Ser Lys Phe Trp 
    210                 215                 220                 


Ser Asp Trp Ser Gln Glu Lys Met Gly Met Thr Glu Glu Glu Ala Pro 
225                 230                 235                 240 


Cys Gly Leu Glu Leu Trp Arg Val Leu Lys Pro Ala Glu Ala Asp Gly 
                245                 250                 255     


Arg Arg Pro Val Arg Leu Leu Trp Lys Lys Ala Arg Gly Ala Pro Val 
            260                 265                 270         


Leu Glu Lys Thr Leu Gly Tyr Asn Ile Trp Tyr Tyr Pro Glu Ser Asn 
        275                 280                 285             


Thr Asn Leu Thr Glu Thr Met Asn Thr Thr Asn Gln Gln Leu Glu Leu 
    290                 295                 300                 


His Leu Gly Gly Glu Ser Phe Trp Val Ser Met Ile Ser Tyr Asn Ser 
305                 310                 315                 320 


Leu Gly Lys Ser Pro Val Ala Thr Leu Arg Ile Pro Ala Ile Gln Glu 
                325                 330                 335     


Lys Ser Phe Gln Cys Ile Glu Val Met Gln Ala Cys Val Ala Glu Asp 
            340                 345                 350         


Gln Leu Val Val Lys Trp Gln Ser Ser Ala Leu Asp Val Asn Thr Trp 
        355                 360                 365             


Met Ile Glu Trp Phe Pro Asp Val Asp Ser Glu Pro Thr Thr Leu Ser 
    370                 375                 380                 


Trp Glu Ser Val Ser Gln Ala Thr Asn Trp Thr Ile Gln Gln Asp Lys 
385                 390                 395                 400 


Leu Lys Pro Phe Trp Cys Tyr Asn Ile Ser Val Tyr Pro Met Leu His 
                405                 410                 415     


Asp Lys Val Gly Glu Pro Tyr Ser Ile Gln Ala Tyr Ala Lys Glu Gly 
            420                 425                 430         


Val Pro Ser Glu Gly Pro Glu Thr Lys Val Glu Asn Ile Gly Val Lys 
        435                 440                 445             


Thr Val Thr Ile Thr Trp Lys Glu Ile Pro Lys Ser Glu Arg Lys Gly 
    450                 455                 460                 


Ile Ile Cys Asn Tyr Thr Ile Phe Tyr Gln Ala Glu Gly Gly Lys Gly 
465                 470                 475                 480 


Phe Ser Lys Thr Val Asn Ser Ser Ile Leu Gln Tyr Gly Leu Glu Ser 
                485                 490                 495     


Leu Lys Arg Lys Thr Ser Tyr Ile Val Gln Val Met Ala Ser Thr Ser 
            500                 505                 510         


Ala Gly Gly Thr Asn Gly Thr Ser Ile Asn Phe Lys Thr Leu Ser Phe 
        515                 520                 525             


Ser Val Phe Glu Ile Ile Leu Ile Thr Ser Leu Ile Gly Gly Gly Leu 
    530                 535                 540                 


Leu Ile Leu Ile Ile Leu Thr Val Ala Tyr Gly Leu Lys Lys Pro Asn 
545                 550                 555                 560 


Lys Leu Thr His Leu Cys Trp Pro Thr Val Pro Asn Pro Ala Glu Ser 
                565                 570                 575     


Ser Ile Ala Thr Trp His Gly Asp Asp Phe Lys Asp Lys Leu Asn Leu 
            580                 585                 590         


Lys Glu Ser Asp Asp Ser Val Asn Thr Glu Asp Arg Ile Leu Lys Pro 
        595                 600                 605             


Cys Ser Thr Pro Ser Asp Lys Leu Val Ile Asp Lys Leu Val Val Asn 
    610                 615                 620                 


Phe Gly Asn Val Leu Gln Glu Ile Phe Thr Asp Glu Ala Arg Thr Gly 
625                 630                 635                 640 


Gln Glu Asn Asn Leu Gly Gly Glu Lys Asn Gly Thr Arg Ile Leu Ser 
                645                 650                 655     


Ser Cys Pro Thr Ser Ile 
            660         


<210>  7039
<211>  662
<212>  PRT
<213>  Homo Sapiens

<400>  7039

Met Lys Leu Ser Pro Gln Pro Ser Cys Val Asn Leu Gly Met Met Trp 
1               5                   10                  15      


Thr Trp Ala Leu Trp Met Leu Pro Ser Leu Cys Lys Phe Ser Leu Ala 
            20                  25                  30          


Ala Leu Pro Ala Lys Pro Glu Asn Ile Ser Cys Val Tyr Tyr Tyr Arg 
        35                  40                  45              


Lys Asn Leu Thr Cys Thr Trp Ser Pro Gly Lys Glu Thr Ser Tyr Thr 
    50                  55                  60                  


Gln Tyr Thr Val Lys Arg Thr Tyr Ala Phe Gly Glu Lys His Asp Asn 
65                  70                  75                  80  


Cys Thr Thr Asn Ser Ser Thr Ser Glu Asn Arg Ala Ser Cys Ser Phe 
                85                  90                  95      


Phe Leu Pro Arg Ile Thr Ile Pro Asp Asn Tyr Thr Ile Glu Val Glu 
            100                 105                 110         


Ala Glu Asn Gly Asp Gly Val Ile Lys Ser His Met Thr Tyr Trp Arg 
        115                 120                 125             


Leu Glu Asn Ile Ala Lys Thr Glu Pro Pro Lys Ile Phe Arg Val Lys 
    130                 135                 140                 


Pro Val Leu Gly Ile Lys Arg Met Ile Gln Ile Glu Trp Ile Lys Pro 
145                 150                 155                 160 


Glu Leu Ala Pro Val Ser Ser Asp Leu Lys Tyr Thr Leu Arg Phe Arg 
                165                 170                 175     


Thr Val Asn Ser Thr Ser Trp Met Glu Val Asn Phe Ala Lys Asn Arg 
            180                 185                 190         


Lys Asp Lys Asn Gln Thr Tyr Asn Leu Thr Gly Leu Gln Pro Phe Thr 
        195                 200                 205             


Glu Tyr Val Ile Ala Leu Arg Cys Ala Val Lys Glu Ser Lys Phe Trp 
    210                 215                 220                 


Ser Asp Trp Ser Gln Glu Lys Met Gly Met Thr Glu Glu Glu Ala Pro 
225                 230                 235                 240 


Cys Gly Leu Glu Leu Trp Arg Val Leu Lys Pro Ala Glu Ala Asp Gly 
                245                 250                 255     


Arg Arg Pro Val Arg Leu Leu Trp Lys Lys Ala Arg Gly Ala Pro Val 
            260                 265                 270         


Leu Glu Lys Thr Leu Gly Tyr Asn Ile Trp Tyr Tyr Pro Glu Ser Asn 
        275                 280                 285             


Thr Asn Leu Thr Glu Thr Met Asn Thr Thr Asn Gln Gln Leu Glu Leu 
    290                 295                 300                 


His Leu Gly Gly Glu Ser Phe Trp Val Ser Met Ile Ser Tyr Asn Ser 
305                 310                 315                 320 


Leu Gly Lys Ser Pro Val Ala Thr Leu Arg Ile Pro Ala Ile Gln Glu 
                325                 330                 335     


Lys Ser Phe Gln Cys Ile Glu Val Met Gln Ala Cys Val Ala Glu Asp 
            340                 345                 350         


Gln Leu Val Val Lys Trp Gln Ser Ser Ala Leu Asp Val Asn Thr Trp 
        355                 360                 365             


Met Ile Glu Trp Phe Pro Asp Val Asp Ser Glu Pro Thr Thr Leu Ser 
    370                 375                 380                 


Trp Glu Ser Val Ser Gln Ala Thr Asn Trp Thr Ile Gln Gln Asp Lys 
385                 390                 395                 400 


Leu Lys Pro Phe Trp Cys Tyr Asn Ile Ser Val Tyr Pro Met Leu His 
                405                 410                 415     


Asp Lys Val Gly Glu Pro Tyr Ser Ile Gln Ala Tyr Ala Lys Glu Gly 
            420                 425                 430         


Val Pro Ser Glu Gly Pro Glu Thr Lys Val Glu Asn Ile Gly Val Lys 
        435                 440                 445             


Thr Val Thr Ile Thr Trp Lys Glu Ile Pro Lys Ser Glu Arg Lys Gly 
    450                 455                 460                 


Ile Ile Cys Asn Tyr Thr Ile Phe Tyr Gln Ala Glu Gly Gly Lys Gly 
465                 470                 475                 480 


Phe Ser Lys Thr Val Asn Ser Ser Ile Leu Gln Tyr Gly Leu Glu Ser 
                485                 490                 495     


Leu Lys Arg Lys Thr Ser Tyr Ile Val Gln Val Met Ala Ser Thr Ser 
            500                 505                 510         


Ala Gly Gly Thr Asn Gly Thr Ser Ile Asn Phe Lys Thr Leu Ser Phe 
        515                 520                 525             


Ser Val Phe Glu Ile Ile Leu Ile Thr Ser Leu Ile Gly Gly Gly Leu 
    530                 535                 540                 


Leu Ile Leu Ile Ile Leu Thr Val Ala Tyr Gly Leu Lys Lys Pro Asn 
545                 550                 555                 560 


Lys Leu Thr His Leu Cys Trp Pro Thr Val Pro Asn Pro Ala Glu Ser 
                565                 570                 575     


Ser Ile Ala Thr Trp His Gly Asp Asp Phe Lys Asp Lys Leu Asn Leu 
            580                 585                 590         


Lys Glu Ser Asp Asp Ser Val Asn Thr Glu Asp Arg Ile Leu Lys Pro 
        595                 600                 605             


Cys Ser Thr Pro Ser Asp Lys Leu Val Ile Asp Lys Leu Val Val Asn 
    610                 615                 620                 


Phe Gly Asn Val Leu Gln Glu Ile Phe Thr Asp Glu Ala Arg Thr Gly 
625                 630                 635                 640 


Gln Glu Asn Asn Leu Gly Gly Glu Lys Asn Gly Thr Arg Ile Leu Ser 
                645                 650                 655     


Ser Cys Pro Thr Ser Ile 
            660         


<210>  7040
<211>  324
<212>  PRT
<213>  Homo Sapiens

<400>  7040

Met Met Trp Thr Trp Ala Leu Trp Met Leu Pro Ser Leu Cys Lys Phe 
1               5                   10                  15      


Ser Leu Ala Ala Leu Pro Ala Lys Pro Glu Asn Ile Ser Cys Val Tyr 
            20                  25                  30          


Tyr Tyr Arg Lys Asn Leu Thr Cys Thr Trp Ser Pro Gly Lys Glu Thr 
        35                  40                  45              


Ser Tyr Thr Gln Tyr Thr Val Lys Arg Thr Tyr Ala Phe Gly Glu Lys 
    50                  55                  60                  


His Asp Asn Cys Thr Thr Asn Ser Ser Thr Ser Glu Asn Arg Ala Ser 
65                  70                  75                  80  


Cys Ser Phe Phe Leu Pro Arg Ile Thr Ile Pro Asp Asn Tyr Thr Ile 
                85                  90                  95      


Glu Val Glu Ala Glu Asn Gly Asp Gly Val Ile Lys Ser His Met Thr 
            100                 105                 110         


Tyr Trp Arg Leu Glu Asn Ile Ala Lys Thr Glu Pro Pro Lys Ile Phe 
        115                 120                 125             


Arg Val Lys Pro Val Leu Gly Ile Lys Arg Met Ile Gln Ile Glu Trp 
    130                 135                 140                 


Ile Lys Pro Glu Leu Ala Pro Val Ser Ser Asp Leu Lys Tyr Thr Leu 
145                 150                 155                 160 


Arg Phe Arg Thr Val Asn Ser Thr Ser Trp Met Glu Val Asn Phe Ala 
                165                 170                 175     


Lys Asn Arg Lys Asp Lys Asn Gln Thr Tyr Asn Leu Thr Gly Leu Gln 
            180                 185                 190         


Pro Phe Thr Glu Tyr Val Ile Ala Leu Arg Cys Ala Val Lys Glu Ser 
        195                 200                 205             


Lys Phe Trp Ser Asp Trp Ser Gln Glu Lys Met Gly Met Thr Glu Glu 
    210                 215                 220                 


Glu Ala Pro Cys Gly Leu Glu Leu Trp Arg Val Leu Lys Pro Ala Glu 
225                 230                 235                 240 


Ala Asp Gly Arg Arg Pro Val Arg Leu Leu Trp Lys Lys Ala Arg Gly 
                245                 250                 255     


Ala Pro Val Leu Glu Lys Thr Leu Gly Tyr Asn Ile Trp Tyr Tyr Pro 
            260                 265                 270         


Glu Ser Asn Thr Asn Leu Thr Glu Thr Met Asn Thr Thr Asn Gln Gln 
        275                 280                 285             


Leu Glu Leu His Leu Gly Gly Glu Ser Phe Trp Val Ser Met Ile Ser 
    290                 295                 300                 


Tyr Asn Ser Leu Gly Lys Ser Pro Val Ala Thr Leu Arg Ile Pro Ala 
305                 310                 315                 320 


Ile Gln Glu Lys 
                


<210>  7041
<211>  622
<212>  PRT
<213>  Homo Sapiens

<400>  7041

Met Thr Tyr Trp Arg Leu Glu Asn Ile Ala Lys Thr Glu Pro Pro Lys 
1               5                   10                  15      


Ile Phe Arg Val Lys Pro Val Leu Gly Ile Lys Arg Met Ile Gln Ile 
            20                  25                  30          


Glu Trp Ile Lys Pro Glu Leu Ala Pro Val Ser Ser Asp Leu Lys Tyr 
        35                  40                  45              


Thr Leu Arg Phe Arg Thr Val Asn Ser Thr Ser Trp Met Glu Val Asn 
    50                  55                  60                  


Phe Ala Lys Asn Arg Lys Asp Lys Asn Gln Thr Tyr Asn Leu Thr Gly 
65                  70                  75                  80  


Leu Gln Pro Phe Thr Glu Tyr Val Ile Ala Leu Arg Cys Ala Val Lys 
                85                  90                  95      


Glu Ser Lys Phe Trp Ser Asp Trp Ser Gln Glu Lys Met Gly Met Thr 
            100                 105                 110         


Glu Glu Glu Ala Pro Cys Gly Leu Glu Leu Trp Arg Val Leu Lys Pro 
        115                 120                 125             


Ala Glu Ala Asp Gly Arg Arg Pro Val Arg Leu Leu Trp Lys Lys Ala 
    130                 135                 140                 


Arg Gly Ala Pro Val Leu Glu Lys Thr Leu Gly Tyr Asn Ile Trp Tyr 
145                 150                 155                 160 


Tyr Pro Glu Ser Asn Thr Asn Leu Thr Glu Thr Met Asn Thr Thr Asn 
                165                 170                 175     


Gln Gln Leu Glu Leu His Leu Gly Gly Glu Ser Phe Trp Val Ser Met 
            180                 185                 190         


Ile Ser Tyr Asn Ser Leu Gly Lys Ser Pro Val Ala Thr Leu Arg Ile 
        195                 200                 205             


Pro Ala Ile Gln Glu Lys Ser Phe Gln Cys Ile Glu Val Met Gln Ala 
    210                 215                 220                 


Cys Val Ala Glu Asp Gln Leu Val Val Lys Trp Gln Ser Ser Ala Leu 
225                 230                 235                 240 


Asp Val Asn Thr Trp Met Ile Glu Trp Phe Pro Asp Val Asp Ser Glu 
                245                 250                 255     


Pro Thr Thr Leu Ser Trp Glu Ser Val Ser Gln Ala Thr Asn Trp Thr 
            260                 265                 270         


Ile Gln Gln Asp Lys Leu Lys Pro Phe Trp Cys Tyr Asn Ile Ser Val 
        275                 280                 285             


Tyr Pro Met Leu His Asp Lys Val Gly Glu Pro Tyr Ser Ile Gln Ala 
    290                 295                 300                 


Tyr Ala Lys Glu Gly Val Pro Ser Glu Gly Pro Glu Thr Lys Val Glu 
305                 310                 315                 320 


Asn Ile Gly Val Lys Thr Val Thr Ile Thr Trp Lys Glu Ile Pro Lys 
                325                 330                 335     


Ser Glu Arg Lys Gly Ile Ile Cys Asn Tyr Thr Ile Phe Tyr Gln Ala 
            340                 345                 350         


Glu Gly Gly Lys Gly Phe Ser Lys Thr Val Asn Ser Ser Ile Leu Gln 
        355                 360                 365             


Tyr Gly Leu Glu Ser Leu Lys Arg Lys Thr Ser Tyr Ile Val Gln Val 
    370                 375                 380                 


Met Ala Ser Thr Ser Ala Gly Gly Thr Asn Gly Thr Ser Ile Asn Phe 
385                 390                 395                 400 


Lys Thr Leu Ser Phe Ser Val Phe Glu Ile Ile Leu Ile Thr Ser Leu 
                405                 410                 415     


Ile Gly Gly Gly Leu Leu Ile Leu Ile Ile Leu Thr Val Ala Tyr Gly 
            420                 425                 430         


Leu Lys Lys Pro Asn Lys Leu Thr His Leu Cys Trp Pro Thr Val Pro 
        435                 440                 445             


Asn Pro Ala Glu Ser Ser Ile Ala Thr Trp His Gly Asp Asp Phe Lys 
    450                 455                 460                 


Asp Lys Leu Asn Leu Lys Glu Ser Asp Asp Ser Val Asn Thr Glu Asp 
465                 470                 475                 480 


Arg Ile Leu Lys Pro Cys Ser Thr Pro Ser Asp Lys Leu Val Ile Asp 
                485                 490                 495     


Lys Leu Val Val Asn Phe Gly Asn Val Leu Gln Glu Ile Phe Thr Asp 
            500                 505                 510         


Glu Ala Arg Thr Gly Gln Glu Asn Asn Leu Gly Gly Glu Lys Asn Gly 
        515                 520                 525             


Tyr Val Thr Cys Pro Phe Arg Pro Asp Cys Pro Leu Gly Lys Ser Phe 
    530                 535                 540                 


Glu Glu Leu Pro Val Ser Pro Glu Ile Pro Pro Arg Lys Ser Gln Tyr 
545                 550                 555                 560 


Leu Arg Ser Arg Met Pro Glu Gly Thr Arg Pro Glu Ala Lys Glu Gln 
                565                 570                 575     


Leu Leu Phe Ser Gly Gln Ser Leu Val Pro Asp His Leu Cys Glu Glu 
            580                 585                 590         


Gly Ala Pro Asn Pro Tyr Leu Lys Asn Ser Val Thr Ala Arg Glu Phe 
        595                 600                 605             


Leu Val Ser Glu Lys Leu Pro Glu His Thr Lys Gly Glu Val 
    610                 615                 620         


<210>  7042
<211>  212
<212>  PRT
<213>  Homo Sapiens

<400>  7042

Met Cys Phe Pro Lys Gly Leu Gly Ala Trp Val Ser Ala Cys Asp Thr 
1               5                   10                  15      


Glu Asp Thr Val Gly His Leu Gly Pro Trp Arg Asp Lys Asp Pro Ala 
            20                  25                  30          


Leu Trp Cys Gln Leu Cys Leu Ser Ser Gln His Gln Ala Ile Glu Arg 
        35                  40                  45              


Phe Tyr Asp Lys Met Gln Asn Ala Glu Ser Gly Arg Gly Gln Val Met 
    50                  55                  60                  


Ser Ser Leu Ala Glu Leu Glu Asp Asp Phe Lys Glu Gly Tyr Leu Glu 
65                  70                  75                  80  


Thr Val Ala Ala Tyr Tyr Glu Glu Gln His Pro Glu Leu Thr Pro Leu 
                85                  90                  95      


Leu Glu Lys Glu Arg Asp Gly Leu Arg Cys Arg Gly Asn Arg Ser Pro 
            100                 105                 110         


Val Pro Asp Val Glu Asp Pro Ala Thr Glu Glu Pro Gly Glu Ser Phe 
        115                 120                 125             


Cys Asp Lys Val Met Arg Trp Phe Gln Ala Met Leu Gln Arg Leu Gln 
    130                 135                 140                 


Thr Trp Trp His Gly Val Leu Ala Trp Val Lys Glu Lys Val Val Ala 
145                 150                 155                 160 


Leu Val His Ala Val Gln Ala Leu Trp Lys Gln Phe Gln Ser Phe Cys 
                165                 170                 175     


Cys Ser Leu Ser Glu Leu Phe Met Ser Ser Phe Gln Ser Tyr Gly Ala 
            180                 185                 190         


Pro Arg Gly Asp Lys Glu Glu Leu Thr Pro Gln Lys Cys Ser Glu Pro 
        195                 200                 205             


Gln Ser Ser Lys 
    210         


<210>  7043
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  7043

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met Asp Asp Phe Lys Glu Gly Tyr Leu Glu Thr Val Ala Ala Tyr 
            20                  25                  30          


Tyr Glu Glu Gln His Pro Glu Leu Thr Pro Leu Leu Glu Lys Glu Arg 
        35                  40                  45              


Asp Gly Leu Arg Cys Arg Gly Asn Arg Ser Pro Val Pro Asp Val Glu 
    50                  55                  60                  


Asp Pro Ala Thr Glu Glu Pro Gly Glu Ser Phe Cys Asp Lys Val Met 
65                  70                  75                  80  


Arg Trp Phe Gln Ala Met Leu Gln Arg Leu Gln Thr Trp Trp His Gly 
                85                  90                  95      


Val Leu Ala Trp Val Lys Glu Lys Val Val Ala Leu Val His Ala Val 
            100                 105                 110         


Gln Ala Leu Trp Lys Gln Phe Gln Ser Phe Cys Cys Ser Leu Ser Glu 
        115                 120                 125             


Leu Phe Met 
    130     


<210>  7044
<211>  179
<212>  PRT
<213>  Homo Sapiens

<400>  7044

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met His Gln Ala Ile Glu Arg Phe Tyr Asp Lys Met Gln Asn Ala 
            20                  25                  30          


Glu Ser Gly Arg Gly Gln Asp Asp Phe Lys Glu Gly Tyr Leu Glu Thr 
        35                  40                  45              


Val Ala Ala Tyr Tyr Glu Glu Gln His Pro Glu Leu Thr Pro Leu Leu 
    50                  55                  60                  


Glu Lys Glu Arg Asp Gly Leu Arg Cys Arg Gly Asn Arg Ser Pro Val 
65                  70                  75                  80  


Pro Asp Val Glu Asp Pro Ala Thr Glu Glu Pro Gly Glu Ser Phe Cys 
                85                  90                  95      


Asp Lys Val Met Arg Trp Phe Gln Ala Met Leu Gln Arg Leu Gln Thr 
            100                 105                 110         


Trp Trp His Gly Val Leu Ala Trp Val Lys Glu Lys Val Val Ala Leu 
        115                 120                 125             


Val His Ala Val Gln Ala Leu Trp Lys Gln Phe Gln Ser Phe Cys Cys 
    130                 135                 140                 


Ser Leu Ser Glu Leu Phe Met Ser Ser Phe Gln Ser Tyr Gly Ala Pro 
145                 150                 155                 160 


Arg Gly Asp Lys Glu Glu Leu Thr Pro Gln Lys Cys Ser Glu Pro Gln 
                165                 170                 175     


Ser Ser Lys 
            


<210>  7045
<211>  179
<212>  PRT
<213>  Homo Sapiens

<400>  7045

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met His Gln Ala Ile Glu Arg Phe Tyr Asp Lys Met Gln Asn Ala 
            20                  25                  30          


Glu Ser Gly Arg Gly Gln Asp Asp Phe Lys Glu Gly Tyr Leu Glu Thr 
        35                  40                  45              


Val Ala Ala Tyr Tyr Glu Glu Gln His Pro Glu Leu Thr Pro Leu Leu 
    50                  55                  60                  


Glu Lys Glu Arg Asp Gly Leu Arg Cys Arg Gly Asn Arg Ser Pro Val 
65                  70                  75                  80  


Pro Asp Val Glu Asp Pro Ala Thr Glu Glu Pro Gly Glu Ser Phe Cys 
                85                  90                  95      


Asp Lys Val Met Arg Trp Phe Gln Ala Met Leu Gln Arg Leu Gln Thr 
            100                 105                 110         


Trp Trp His Gly Val Leu Ala Trp Val Lys Glu Lys Val Val Ala Leu 
        115                 120                 125             


Val His Ala Val Gln Ala Leu Trp Lys Gln Phe Gln Ser Phe Cys Cys 
    130                 135                 140                 


Ser Leu Ser Glu Leu Phe Met Ser Ser Phe Gln Ser Tyr Gly Ala Pro 
145                 150                 155                 160 


Arg Gly Asp Lys Glu Glu Leu Thr Pro Gln Lys Cys Ser Glu Pro Gln 
                165                 170                 175     


Ser Ser Lys 
            


<210>  7046
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  7046

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met His Gln Ala Ile Glu Arg Phe Tyr Asp Lys Met Gln Asn Ala 
            20                  25                  30          


Glu Ser Gly Arg Gly Gln Val Met Ser Ser Leu Ala Glu Leu Glu Asp 
        35                  40                  45              


Asp Phe Lys Glu Gly Tyr Leu Glu Thr Val Ala Ala Tyr Tyr Glu Glu 
    50                  55                  60                  


Gln His Pro Glu Leu Thr Pro Leu Leu Glu Lys Glu Arg Asp Gly Leu 
65                  70                  75                  80  


Arg Cys Arg Gly Asn Arg Ser Pro Val Pro Asp Val Glu Asp Pro Ala 
                85                  90                  95      


Thr Glu Glu Pro Gly Glu Ser Phe Cys Asp Lys Ser Tyr Gly Ala Pro 
            100                 105                 110         


Arg Gly Asp Lys Glu Glu Leu Thr Pro Gln Lys Cys Ser Glu Pro Gln 
        115                 120                 125             


Ser Ser Lys 
    130     


<210>  7047
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  7047

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met His Gln Ala Ile Glu Arg Phe Tyr Asp Lys Met Gln Asn Ala 
            20                  25                  30          


Glu Ser Gly Arg Gly Gln Val Met Ser Ser Leu Ala Glu Leu Glu Asp 
        35                  40                  45              


Asp Phe Lys Glu Gly Tyr Leu Glu Thr Val Ala Ala Tyr Tyr Glu Glu 
    50                  55                  60                  


Gln His Pro Glu Leu Thr Pro Leu Leu Glu Lys Glu Arg Asp Gly Leu 
65                  70                  75                  80  


Arg Cys Arg Gly Asn Arg Ser Pro Val Pro Asp Val Glu Asp Pro Ala 
                85                  90                  95      


Thr Glu Glu Pro Gly Glu Ser Phe Cys Asp Lys Ser Tyr Gly Ala Pro 
            100                 105                 110         


Arg Gly Asp Lys Glu Glu Leu Thr Pro Gln Lys Cys Ser Glu Pro Gln 
        115                 120                 125             


Ser Ser Lys 
    130     


<210>  7048
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  7048

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met His Gln Ala Ile Glu Arg Phe Tyr Asp Lys Met Gln Asn Ala 
            20                  25                  30          


Glu Ser Gly Arg Gly Gln Val Met Ser Ser Leu Ala Glu Leu Glu Asp 
        35                  40                  45              


Asp Phe Lys Glu Gly Tyr Leu Glu Thr Val Ala Ala Tyr Tyr Glu Glu 
    50                  55                  60                  


Gln His Pro Glu Leu Thr Pro Leu Leu Glu Lys Glu Arg Asp Gly Leu 
65                  70                  75                  80  


Arg Cys Arg Gly Asn Arg Ser Pro Val Pro Asp Val Glu Asp Pro Ala 
                85                  90                  95      


Thr Glu Glu Pro Gly Glu Ser Phe Cys Asp Lys Ser Tyr Gly Ala Pro 
            100                 105                 110         


Arg Gly Asp Lys Glu Glu Leu Thr Pro Gln Lys Cys Ser Glu Pro Gln 
        115                 120                 125             


Ser Ser Lys 
    130     


<210>  7049
<211>  188
<212>  PRT
<213>  Homo Sapiens

<400>  7049

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met His Gln Ala Ile Glu Arg Phe Tyr Asp Lys Met Gln Asn Ala 
            20                  25                  30          


Glu Ser Gly Arg Gly Gln Val Met Ser Ser Leu Ala Glu Leu Glu Asp 
        35                  40                  45              


Asp Phe Lys Glu Gly Tyr Leu Glu Thr Val Ala Ala Tyr Tyr Glu Glu 
    50                  55                  60                  


Gln His Pro Glu Leu Thr Pro Leu Leu Glu Lys Glu Arg Asp Gly Leu 
65                  70                  75                  80  


Arg Cys Arg Gly Asn Arg Ser Pro Val Pro Asp Val Glu Asp Pro Ala 
                85                  90                  95      


Thr Glu Glu Pro Gly Glu Ser Phe Cys Asp Lys Val Met Arg Trp Phe 
            100                 105                 110         


Gln Ala Met Leu Gln Arg Leu Gln Thr Trp Trp His Gly Val Leu Ala 
        115                 120                 125             


Trp Val Lys Glu Lys Val Val Ala Leu Val His Ala Val Gln Ala Leu 
    130                 135                 140                 


Trp Lys Gln Phe Gln Ser Phe Cys Cys Ser Leu Ser Glu Leu Phe Met 
145                 150                 155                 160 


Ser Ser Phe Gln Ser Tyr Gly Ala Pro Arg Gly Asp Lys Glu Glu Leu 
                165                 170                 175     


Thr Pro Gln Lys Cys Ser Glu Pro Gln Ser Ser Lys 
            180                 185             


<210>  7050
<211>  188
<212>  PRT
<213>  Homo Sapiens

<400>  7050

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met His Gln Ala Ile Glu Arg Phe Tyr Asp Lys Met Gln Asn Ala 
            20                  25                  30          


Glu Ser Gly Arg Gly Gln Val Met Ser Ser Leu Ala Glu Leu Glu Asp 
        35                  40                  45              


Asp Phe Lys Glu Gly Tyr Leu Glu Thr Val Ala Ala Tyr Tyr Glu Glu 
    50                  55                  60                  


Gln His Pro Glu Leu Thr Pro Leu Leu Glu Lys Glu Arg Asp Gly Leu 
65                  70                  75                  80  


Arg Cys Arg Gly Asn Arg Ser Pro Val Pro Asp Val Glu Asp Pro Ala 
                85                  90                  95      


Thr Glu Glu Pro Gly Glu Ser Phe Cys Asp Lys Val Met Arg Trp Phe 
            100                 105                 110         


Gln Ala Met Leu Gln Arg Leu Gln Thr Trp Trp His Gly Val Leu Ala 
        115                 120                 125             


Trp Val Lys Glu Lys Val Val Ala Leu Val His Ala Val Gln Ala Leu 
    130                 135                 140                 


Trp Lys Gln Phe Gln Ser Phe Cys Cys Ser Leu Ser Glu Leu Phe Met 
145                 150                 155                 160 


Ser Ser Phe Gln Ser Tyr Gly Ala Pro Arg Gly Asp Lys Glu Glu Leu 
                165                 170                 175     


Thr Pro Gln Lys Cys Ser Glu Pro Gln Ser Ser Lys 
            180                 185             


<210>  7051
<211>  188
<212>  PRT
<213>  Homo Sapiens

<400>  7051

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met His Gln Ala Ile Glu Arg Phe Tyr Asp Lys Met Gln Asn Ala 
            20                  25                  30          


Glu Ser Gly Arg Gly Gln Val Met Ser Ser Leu Ala Glu Leu Glu Asp 
        35                  40                  45              


Asp Phe Lys Glu Gly Tyr Leu Glu Thr Val Ala Ala Tyr Tyr Glu Glu 
    50                  55                  60                  


Gln His Pro Glu Leu Thr Pro Leu Leu Glu Lys Glu Arg Asp Gly Leu 
65                  70                  75                  80  


Arg Cys Arg Gly Asn Arg Ser Pro Val Pro Asp Val Glu Asp Pro Ala 
                85                  90                  95      


Thr Glu Glu Pro Gly Glu Ser Phe Cys Asp Lys Val Met Arg Trp Phe 
            100                 105                 110         


Gln Ala Met Leu Gln Arg Leu Gln Thr Trp Trp His Gly Val Leu Ala 
        115                 120                 125             


Trp Val Lys Glu Lys Val Val Ala Leu Val His Ala Val Gln Ala Leu 
    130                 135                 140                 


Trp Lys Gln Phe Gln Ser Phe Cys Cys Ser Leu Ser Glu Leu Phe Met 
145                 150                 155                 160 


Ser Ser Phe Gln Ser Tyr Gly Ala Pro Arg Gly Asp Lys Glu Glu Leu 
                165                 170                 175     


Thr Pro Gln Lys Cys Ser Glu Pro Gln Ser Ser Lys 
            180                 185             


<210>  7052
<211>  188
<212>  PRT
<213>  Homo Sapiens

<400>  7052

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met His Gln Ala Ile Glu Arg Phe Tyr Asp Lys Met Gln Asn Ala 
            20                  25                  30          


Glu Ser Gly Arg Gly Gln Val Met Ser Ser Leu Ala Glu Leu Glu Asp 
        35                  40                  45              


Asp Phe Lys Glu Gly Tyr Leu Glu Thr Val Ala Ala Tyr Tyr Glu Glu 
    50                  55                  60                  


Gln His Pro Glu Leu Thr Pro Leu Leu Glu Lys Glu Arg Asp Gly Leu 
65                  70                  75                  80  


Arg Cys Arg Gly Asn Arg Ser Pro Val Pro Asp Val Glu Asp Pro Ala 
                85                  90                  95      


Thr Glu Glu Pro Gly Glu Ser Phe Cys Asp Lys Val Met Arg Trp Phe 
            100                 105                 110         


Gln Ala Met Leu Gln Arg Leu Gln Thr Trp Trp His Gly Val Leu Ala 
        115                 120                 125             


Trp Val Lys Glu Lys Val Val Ala Leu Val His Ala Val Gln Ala Leu 
    130                 135                 140                 


Trp Lys Gln Phe Gln Ser Phe Cys Cys Ser Leu Ser Glu Leu Phe Met 
145                 150                 155                 160 


Ser Ser Phe Gln Ser Tyr Gly Ala Pro Arg Gly Asp Lys Glu Glu Leu 
                165                 170                 175     


Thr Pro Gln Lys Cys Ser Glu Pro Gln Ser Ser Lys 
            180                 185             


<210>  7053
<211>  188
<212>  PRT
<213>  Homo Sapiens

<400>  7053

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met His Gln Ala Ile Glu Arg Phe Tyr Asp Lys Met Gln Asn Ala 
            20                  25                  30          


Glu Ser Gly Arg Gly Gln Val Met Ser Ser Leu Ala Glu Leu Glu Asp 
        35                  40                  45              


Asp Phe Lys Glu Gly Tyr Leu Glu Thr Val Ala Ala Tyr Tyr Glu Glu 
    50                  55                  60                  


Gln His Pro Glu Leu Thr Pro Leu Leu Glu Lys Glu Arg Asp Gly Leu 
65                  70                  75                  80  


Arg Cys Arg Gly Asn Arg Ser Pro Val Pro Asp Val Glu Asp Pro Ala 
                85                  90                  95      


Thr Glu Glu Pro Gly Glu Ser Phe Cys Asp Lys Val Met Arg Trp Phe 
            100                 105                 110         


Gln Ala Met Leu Gln Arg Leu Gln Thr Trp Trp His Gly Val Leu Ala 
        115                 120                 125             


Trp Val Lys Glu Lys Val Val Ala Leu Val His Ala Val Gln Ala Leu 
    130                 135                 140                 


Trp Lys Gln Phe Gln Ser Phe Cys Cys Ser Leu Ser Glu Leu Phe Met 
145                 150                 155                 160 


Ser Ser Phe Gln Ser Tyr Gly Ala Pro Arg Gly Asp Lys Glu Glu Leu 
                165                 170                 175     


Thr Pro Gln Lys Cys Ser Glu Pro Gln Ser Ser Lys 
            180                 185             


<210>  7054
<211>  188
<212>  PRT
<213>  Homo Sapiens

<400>  7054

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met His Gln Ala Ile Glu Arg Phe Tyr Asp Lys Met Gln Asn Ala 
            20                  25                  30          


Glu Ser Gly Arg Gly Gln Val Met Ser Ser Leu Ala Glu Leu Glu Asp 
        35                  40                  45              


Asp Phe Lys Glu Gly Tyr Leu Glu Thr Val Ala Ala Tyr Tyr Glu Glu 
    50                  55                  60                  


Gln His Pro Glu Leu Thr Pro Leu Leu Glu Lys Glu Arg Asp Gly Leu 
65                  70                  75                  80  


Arg Cys Arg Gly Asn Arg Ser Pro Val Pro Asp Val Glu Asp Pro Ala 
                85                  90                  95      


Thr Glu Glu Pro Gly Glu Ser Phe Cys Asp Lys Val Met Arg Trp Phe 
            100                 105                 110         


Gln Ala Met Leu Gln Arg Leu Gln Thr Trp Trp His Gly Val Leu Ala 
        115                 120                 125             


Trp Val Lys Glu Lys Val Val Ala Leu Val His Ala Val Gln Ala Leu 
    130                 135                 140                 


Trp Lys Gln Phe Gln Ser Phe Cys Cys Ser Leu Ser Glu Leu Phe Met 
145                 150                 155                 160 


Ser Ser Phe Gln Ser Tyr Gly Ala Pro Arg Gly Asp Lys Glu Glu Leu 
                165                 170                 175     


Thr Pro Gln Lys Cys Ser Glu Pro Gln Ser Ser Lys 
            180                 185             


<210>  7055
<211>  188
<212>  PRT
<213>  Homo Sapiens

<400>  7055

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met His Gln Ala Ile Glu Arg Phe Tyr Asp Lys Met Gln Asn Ala 
            20                  25                  30          


Glu Ser Gly Arg Gly Gln Val Met Ser Ser Leu Ala Glu Leu Glu Asp 
        35                  40                  45              


Asp Phe Lys Glu Gly Tyr Leu Glu Thr Val Ala Ala Tyr Tyr Glu Glu 
    50                  55                  60                  


Gln His Pro Glu Leu Thr Pro Leu Leu Glu Lys Glu Arg Asp Gly Leu 
65                  70                  75                  80  


Arg Cys Arg Gly Asn Arg Ser Pro Val Pro Asp Val Glu Asp Pro Ala 
                85                  90                  95      


Thr Glu Glu Pro Gly Glu Ser Phe Cys Asp Lys Val Met Arg Trp Phe 
            100                 105                 110         


Gln Ala Met Leu Gln Arg Leu Gln Thr Trp Trp His Gly Val Leu Ala 
        115                 120                 125             


Trp Val Lys Glu Lys Val Val Ala Leu Val His Ala Val Gln Ala Leu 
    130                 135                 140                 


Trp Lys Gln Phe Gln Ser Phe Cys Cys Ser Leu Ser Glu Leu Phe Met 
145                 150                 155                 160 


Ser Ser Phe Gln Ser Tyr Gly Ala Pro Arg Gly Asp Lys Glu Glu Leu 
                165                 170                 175     


Thr Pro Gln Lys Cys Ser Glu Pro Gln Ser Ser Lys 
            180                 185             


<210>  7056
<211>  188
<212>  PRT
<213>  Homo Sapiens

<400>  7056

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met His Gln Ala Ile Glu Arg Phe Tyr Asp Lys Met Gln Asn Ala 
            20                  25                  30          


Glu Ser Gly Arg Gly Gln Val Met Ser Ser Leu Ala Glu Leu Glu Asp 
        35                  40                  45              


Asp Phe Lys Glu Gly Tyr Leu Glu Thr Val Ala Ala Tyr Tyr Glu Glu 
    50                  55                  60                  


Gln His Pro Glu Leu Thr Pro Leu Leu Glu Lys Glu Arg Asp Gly Leu 
65                  70                  75                  80  


Arg Cys Arg Gly Asn Arg Ser Pro Val Pro Asp Val Glu Asp Pro Ala 
                85                  90                  95      


Thr Glu Glu Pro Gly Glu Ser Phe Cys Asp Lys Val Met Arg Trp Phe 
            100                 105                 110         


Gln Ala Met Leu Gln Arg Leu Gln Thr Trp Trp His Gly Val Leu Ala 
        115                 120                 125             


Trp Val Lys Glu Lys Val Val Ala Leu Val His Ala Val Gln Ala Leu 
    130                 135                 140                 


Trp Lys Gln Phe Gln Ser Phe Cys Cys Ser Leu Ser Glu Leu Phe Met 
145                 150                 155                 160 


Ser Ser Phe Gln Ser Tyr Gly Ala Pro Arg Gly Asp Lys Glu Glu Leu 
                165                 170                 175     


Thr Pro Gln Lys Cys Ser Glu Pro Gln Ser Ser Lys 
            180                 185             


<210>  7057
<211>  188
<212>  PRT
<213>  Homo Sapiens

<400>  7057

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met His Gln Ala Ile Glu Arg Phe Tyr Asp Lys Met Gln Asn Ala 
            20                  25                  30          


Glu Ser Gly Arg Gly Gln Val Met Ser Ser Leu Ala Glu Leu Glu Asp 
        35                  40                  45              


Asp Phe Lys Glu Gly Tyr Leu Glu Thr Val Ala Ala Tyr Tyr Glu Glu 
    50                  55                  60                  


Gln His Pro Glu Leu Thr Pro Leu Leu Glu Lys Glu Arg Asp Gly Leu 
65                  70                  75                  80  


Arg Cys Arg Gly Asn Arg Ser Pro Val Pro Asp Val Glu Asp Pro Ala 
                85                  90                  95      


Thr Glu Glu Pro Gly Glu Ser Phe Cys Asp Lys Val Met Arg Trp Phe 
            100                 105                 110         


Gln Ala Met Leu Gln Arg Leu Gln Thr Trp Trp His Gly Val Leu Ala 
        115                 120                 125             


Trp Val Lys Glu Lys Val Val Ala Leu Val His Ala Val Gln Ala Leu 
    130                 135                 140                 


Trp Lys Gln Phe Gln Ser Phe Cys Cys Ser Leu Ser Glu Leu Phe Met 
145                 150                 155                 160 


Ser Ser Phe Gln Ser Tyr Gly Ala Pro Arg Gly Asp Lys Glu Glu Leu 
                165                 170                 175     


Thr Pro Gln Lys Cys Ser Glu Pro Gln Ser Ser Lys 
            180                 185             


<210>  7058
<211>  188
<212>  PRT
<213>  Homo Sapiens

<400>  7058

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met His Gln Ala Ile Glu Arg Phe Tyr Asp Lys Met Gln Asn Ala 
            20                  25                  30          


Glu Ser Gly Arg Gly Gln Val Met Ser Ser Leu Ala Glu Leu Glu Asp 
        35                  40                  45              


Asp Phe Lys Glu Gly Tyr Leu Glu Thr Val Ala Ala Tyr Tyr Glu Glu 
    50                  55                  60                  


Gln His Pro Glu Leu Thr Pro Leu Leu Glu Lys Glu Arg Asp Gly Leu 
65                  70                  75                  80  


Arg Cys Arg Gly Asn Arg Ser Pro Val Pro Asp Val Glu Asp Pro Ala 
                85                  90                  95      


Thr Glu Glu Pro Gly Glu Ser Phe Cys Asp Lys Val Met Arg Trp Phe 
            100                 105                 110         


Gln Ala Met Leu Gln Arg Leu Gln Thr Trp Trp His Gly Val Leu Ala 
        115                 120                 125             


Trp Val Lys Glu Lys Val Val Ala Leu Val His Ala Val Gln Ala Leu 
    130                 135                 140                 


Trp Lys Gln Phe Gln Ser Phe Cys Cys Ser Leu Ser Glu Leu Phe Met 
145                 150                 155                 160 


Ser Ser Phe Gln Ser Tyr Gly Ala Pro Arg Gly Asp Lys Glu Glu Leu 
                165                 170                 175     


Thr Pro Gln Lys Cys Ser Glu Pro Gln Ser Ser Lys 
            180                 185             


<210>  7059
<211>  168
<212>  PRT
<213>  Homo Sapiens

<400>  7059

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met His Gln Ala Ile Glu Arg Phe Tyr Asp Lys Met Gln Asn Ala 
            20                  25                  30          


Glu Ser Gly Arg Gly Gln Val Met Ser Ser Leu Ala Glu Leu Glu Glu 
        35                  40                  45              


Leu Thr Pro Leu Leu Glu Lys Glu Arg Asp Gly Leu Arg Cys Arg Gly 
    50                  55                  60                  


Asn Arg Ser Pro Val Pro Asp Val Glu Asp Pro Ala Thr Glu Glu Pro 
65                  70                  75                  80  


Gly Glu Ser Phe Cys Asp Lys Val Met Arg Trp Phe Gln Ala Met Leu 
                85                  90                  95      


Gln Arg Leu Gln Thr Trp Trp His Gly Val Leu Ala Trp Val Lys Glu 
            100                 105                 110         


Lys Val Val Ala Leu Val His Ala Val Gln Ala Leu Trp Lys Gln Phe 
        115                 120                 125             


Gln Ser Phe Cys Cys Ser Leu Ser Glu Leu Phe Met Ser Ser Phe Gln 
    130                 135                 140                 


Ser Tyr Gly Ala Pro Arg Gly Asp Lys Glu Glu Leu Thr Pro Gln Lys 
145                 150                 155                 160 


Cys Ser Glu Pro Gln Ser Ser Lys 
                165             


<210>  7060
<211>  168
<212>  PRT
<213>  Homo Sapiens

<400>  7060

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met His Gln Ala Ile Glu Arg Phe Tyr Asp Lys Met Gln Asn Ala 
            20                  25                  30          


Glu Ser Gly Arg Gly Gln Val Met Ser Ser Leu Ala Glu Leu Glu Glu 
        35                  40                  45              


Leu Thr Pro Leu Leu Glu Lys Glu Arg Asp Gly Leu Arg Cys Arg Gly 
    50                  55                  60                  


Asn Arg Ser Pro Val Pro Asp Val Glu Asp Pro Ala Thr Glu Glu Pro 
65                  70                  75                  80  


Gly Glu Ser Phe Cys Asp Lys Val Met Arg Trp Phe Gln Ala Met Leu 
                85                  90                  95      


Gln Arg Leu Gln Thr Trp Trp His Gly Val Leu Ala Trp Val Lys Glu 
            100                 105                 110         


Lys Val Val Ala Leu Val His Ala Val Gln Ala Leu Trp Lys Gln Phe 
        115                 120                 125             


Gln Ser Phe Cys Cys Ser Leu Ser Glu Leu Phe Met Ser Ser Phe Gln 
    130                 135                 140                 


Ser Tyr Gly Ala Pro Arg Gly Asp Lys Glu Glu Leu Thr Pro Gln Lys 
145                 150                 155                 160 


Cys Ser Glu Pro Gln Ser Ser Lys 
                165             


<210>  7061
<211>  225
<212>  PRT
<213>  Homo Sapiens

<400>  7061

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met Val Met Leu Leu Pro Thr Ser Ala Gln Gly Leu Gly Ala Trp 
            20                  25                  30          


Val Ser Ala Cys Asp Thr Glu Asp Thr Val Gly His Leu Gly Pro Trp 
        35                  40                  45              


Arg Asp Lys Asp Pro Ala Leu Trp Cys Gln Leu Cys Leu Ser Ser Gln 
    50                  55                  60                  


His Gln Ala Ile Glu Arg Phe Tyr Asp Lys Met Gln Asn Ala Glu Ser 
65                  70                  75                  80  


Gly Arg Gly Gln Asp Asp Phe Lys Glu Gly Tyr Leu Glu Thr Val Ala 
                85                  90                  95      


Ala Tyr Tyr Glu Glu Gln His Pro Glu Leu Thr Pro Leu Leu Glu Lys 
            100                 105                 110         


Glu Arg Asp Gly Leu Arg Cys Arg Gly Asn Arg Ser Pro Val Pro Asp 
        115                 120                 125             


Val Glu Asp Pro Ala Thr Glu Glu Pro Gly Glu Ser Phe Cys Asp Lys 
    130                 135                 140                 


Val Met Arg Trp Phe Gln Ala Met Leu Gln Arg Leu Gln Thr Trp Trp 
145                 150                 155                 160 


His Gly Val Leu Ala Trp Val Lys Glu Lys Val Val Ala Leu Val His 
                165                 170                 175     


Ala Val Gln Ala Leu Trp Lys Gln Phe Gln Ser Phe Cys Cys Ser Leu 
            180                 185                 190         


Ser Glu Leu Phe Met Ser Ser Phe Gln Ser Tyr Gly Ala Pro Arg Gly 
        195                 200                 205             


Asp Lys Glu Glu Leu Thr Pro Gln Lys Cys Ser Glu Pro Gln Ser Ser 
    210                 215                 220                 


Lys 
225 


<210>  7062
<211>  225
<212>  PRT
<213>  Homo Sapiens

<400>  7062

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met Val Met Leu Leu Pro Thr Ser Ala Gln Gly Leu Gly Ala Trp 
            20                  25                  30          


Val Ser Ala Cys Asp Thr Glu Asp Thr Val Gly His Leu Gly Pro Trp 
        35                  40                  45              


Arg Asp Lys Asp Pro Ala Leu Trp Cys Gln Leu Cys Leu Ser Ser Gln 
    50                  55                  60                  


His Gln Ala Ile Glu Arg Phe Tyr Asp Lys Met Gln Asn Ala Glu Ser 
65                  70                  75                  80  


Gly Arg Gly Gln Val Met Ser Ser Leu Ala Glu Leu Glu Asp Asp Phe 
                85                  90                  95      


Lys Glu Gly Tyr Leu Glu Thr Val Ala Ala Tyr Tyr Glu Glu Gln His 
            100                 105                 110         


Pro Glu Leu Thr Pro Leu Leu Glu Lys Glu Arg Asp Gly Leu Arg Cys 
        115                 120                 125             


Arg Gly Asn Arg Ser Pro Val Pro Asp Val Glu Asp Pro Ala Thr Glu 
    130                 135                 140                 


Glu Pro Gly Glu Ser Phe Cys Asp Lys Val Met Arg Trp Phe Gln Ala 
145                 150                 155                 160 


Met Leu Gln Arg Leu Gln Thr Trp Trp His Gly Val Leu Ala Trp Val 
                165                 170                 175     


Lys Glu Lys Val Val Ala Leu Val His Ala Val Gln Ala Leu Trp Lys 
            180                 185                 190         


Gln Phe Gln Ser Phe Cys Cys Ser Leu Ser Glu Leu Phe Met Ser Ser 
        195                 200                 205             


Phe Gln Ser Tyr Gly Ala Pro Arg Gly Asp Lys Glu Glu Leu Thr Pro 
    210                 215                 220                 


Gln 
225 


<210>  7063
<211>  234
<212>  PRT
<213>  Homo Sapiens

<400>  7063

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met Val Met Leu Leu Pro Thr Ser Ala Gln Gly Leu Gly Ala Trp 
            20                  25                  30          


Val Ser Ala Cys Asp Thr Glu Asp Thr Val Gly His Leu Gly Pro Trp 
        35                  40                  45              


Arg Asp Lys Asp Pro Ala Leu Trp Cys Gln Leu Cys Leu Ser Ser Gln 
    50                  55                  60                  


His Gln Ala Ile Glu Arg Phe Tyr Asp Lys Met Gln Asn Ala Glu Ser 
65                  70                  75                  80  


Gly Arg Gly Gln Val Met Ser Ser Leu Ala Glu Leu Glu Asp Asp Phe 
                85                  90                  95      


Lys Glu Gly Tyr Leu Glu Thr Val Ala Ala Tyr Tyr Glu Glu Gln His 
            100                 105                 110         


Pro Glu Leu Thr Pro Leu Leu Glu Lys Glu Arg Asp Gly Leu Arg Cys 
        115                 120                 125             


Arg Gly Asn Arg Ser Pro Val Pro Asp Val Glu Asp Pro Ala Thr Glu 
    130                 135                 140                 


Glu Pro Gly Glu Ser Phe Cys Asp Lys Val Met Arg Trp Phe Gln Ala 
145                 150                 155                 160 


Met Leu Gln Arg Leu Gln Thr Trp Trp His Gly Val Leu Ala Trp Val 
                165                 170                 175     


Lys Glu Lys Val Val Ala Leu Val His Ala Val Gln Ala Leu Trp Lys 
            180                 185                 190         


Gln Phe Gln Ser Phe Cys Cys Ser Leu Ser Glu Leu Phe Met Ser Ser 
        195                 200                 205             


Phe Gln Ser Tyr Gly Ala Pro Arg Gly Asp Lys Glu Glu Leu Thr Pro 
    210                 215                 220                 


Gln Lys Cys Ser Glu Pro Gln Ser Ser Lys 
225                 230                 


<210>  7064
<211>  234
<212>  PRT
<213>  Homo Sapiens

<400>  7064

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met Val Met Leu Leu Pro Thr Ser Ala Gln Gly Leu Gly Ala Trp 
            20                  25                  30          


Val Ser Ala Cys Asp Thr Glu Asp Thr Val Gly His Leu Gly Pro Trp 
        35                  40                  45              


Arg Asp Lys Asp Pro Ala Leu Trp Cys Gln Leu Cys Leu Ser Ser Gln 
    50                  55                  60                  


His Gln Ala Ile Glu Arg Phe Tyr Asp Lys Met Gln Asn Ala Glu Ser 
65                  70                  75                  80  


Gly Arg Gly Gln Val Met Ser Ser Leu Ala Glu Leu Glu Asp Asp Phe 
                85                  90                  95      


Lys Glu Gly Tyr Leu Glu Thr Val Ala Ala Tyr Tyr Glu Glu Gln His 
            100                 105                 110         


Pro Glu Leu Thr Pro Leu Leu Glu Lys Glu Arg Asp Gly Leu Arg Cys 
        115                 120                 125             


Arg Gly Asn Arg Ser Pro Val Pro Asp Val Glu Asp Pro Ala Thr Glu 
    130                 135                 140                 


Glu Pro Gly Glu Ser Phe Cys Asp Lys Val Met Arg Trp Phe Gln Ala 
145                 150                 155                 160 


Met Leu Gln Arg Leu Gln Thr Trp Trp His Gly Val Leu Ala Trp Val 
                165                 170                 175     


Lys Glu Lys Val Val Ala Leu Val His Ala Val Gln Ala Leu Trp Lys 
            180                 185                 190         


Gln Phe Gln Ser Phe Cys Cys Ser Leu Ser Glu Leu Phe Met Ser Ser 
        195                 200                 205             


Phe Gln Ser Tyr Gly Ala Pro Arg Gly Asp Lys Glu Glu Leu Thr Pro 
    210                 215                 220                 


Gln Lys Cys Ser Glu Pro Gln Ser Ser Lys 
225                 230                 


<210>  7065
<211>  234
<212>  PRT
<213>  Homo Sapiens

<400>  7065

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met Val Met Leu Leu Pro Thr Ser Ala Gln Gly Leu Gly Ala Trp 
            20                  25                  30          


Val Ser Ala Cys Asp Thr Glu Asp Thr Val Gly His Leu Gly Pro Trp 
        35                  40                  45              


Arg Asp Lys Asp Pro Ala Leu Trp Cys Gln Leu Cys Leu Ser Ser Gln 
    50                  55                  60                  


His Gln Ala Ile Glu Arg Phe Tyr Asp Lys Met Gln Asn Ala Glu Ser 
65                  70                  75                  80  


Gly Arg Gly Gln Val Met Ser Ser Leu Ala Glu Leu Glu Asp Asp Phe 
                85                  90                  95      


Lys Glu Gly Tyr Leu Glu Thr Val Ala Ala Tyr Tyr Glu Glu Gln His 
            100                 105                 110         


Pro Glu Leu Thr Pro Leu Leu Glu Lys Glu Arg Asp Gly Leu Arg Cys 
        115                 120                 125             


Arg Gly Asn Arg Ser Pro Val Pro Asp Val Glu Asp Pro Ala Thr Glu 
    130                 135                 140                 


Glu Pro Gly Glu Ser Phe Cys Asp Lys Val Met Arg Trp Phe Gln Ala 
145                 150                 155                 160 


Met Leu Gln Arg Leu Gln Thr Trp Trp His Gly Val Leu Ala Trp Val 
                165                 170                 175     


Lys Glu Lys Val Val Ala Leu Val His Ala Val Gln Ala Leu Trp Lys 
            180                 185                 190         


Gln Phe Gln Ser Phe Cys Cys Ser Leu Ser Glu Leu Phe Met Ser Ser 
        195                 200                 205             


Phe Gln Ser Tyr Gly Ala Pro Arg Gly Asp Lys Glu Glu Leu Thr Pro 
    210                 215                 220                 


Gln Lys Cys Ser Glu Pro Gln Ser Ser Lys 
225                 230                 


<210>  7066
<211>  221
<212>  PRT
<213>  Homo Sapiens

<400>  7066

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met Val Met Leu Leu Pro Thr Ser Ala Gln Gly Leu Gly Ala Trp 
            20                  25                  30          


Val Ser Ala Cys Asp Thr Glu Asp Thr Val Gly His Leu Gly Pro Trp 
        35                  40                  45              


Arg Asp Lys Asp Pro Ala Leu Trp Cys Gln Leu Cys Leu Ser Ser Gln 
    50                  55                  60                  


His Gln Ala Ile Glu Arg Phe Tyr Asp Lys Met Gln Asn Ala Glu Ser 
65                  70                  75                  80  


Gly Arg Gly Gln Val Met Ser Ser Leu Ala Glu Leu Glu Asp Asp Phe 
                85                  90                  95      


Lys Glu Gly Tyr Leu Glu Thr Val Ala Ala Tyr Tyr Glu Glu Gln His 
            100                 105                 110         


Pro Glu Leu Thr Pro Leu Leu Glu Lys Glu Arg Asp Gly Leu Arg Cys 
        115                 120                 125             


Arg Gly Asn Arg Ser Pro Val Pro Asp Val Glu Asp Pro Ala Thr Glu 
    130                 135                 140                 


Glu Pro Gly Glu Ser Phe Cys Asp Lys Val Met Arg Trp Phe Gln Ala 
145                 150                 155                 160 


Met Leu Gln Arg Leu Gln Thr Trp Trp His Gly Val Leu Ala Trp Val 
                165                 170                 175     


Lys Glu Lys Val Val Ala Leu Val His Ala Val Gln Ala Leu Trp Lys 
            180                 185                 190         


Gln Phe Gln Ser Phe Cys Cys Ser Leu Ser Glu Leu Phe Met Ser Ser 
        195                 200                 205             


Phe Gln Ser Tyr Gly Ala Thr Arg Gly Ala Arg Arg Ser 
    210                 215                 220     


<210>  7067
<211>  168
<212>  PRT
<213>  Homo Sapiens

<400>  7067

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met Val Met Ser Ser Leu Ala Glu Leu Glu Asp Asp Phe Lys Glu 
            20                  25                  30          


Gly Tyr Leu Glu Thr Val Ala Ala Tyr Tyr Glu Glu Gln His Pro Glu 
        35                  40                  45              


Leu Thr Pro Leu Leu Glu Lys Glu Arg Asp Gly Leu Arg Cys Arg Gly 
    50                  55                  60                  


Asn Arg Ser Pro Val Pro Asp Val Glu Asp Pro Ala Thr Glu Glu Pro 
65                  70                  75                  80  


Gly Glu Ser Phe Cys Asp Lys Val Met Arg Trp Phe Gln Ala Met Leu 
                85                  90                  95      


Gln Arg Leu Gln Thr Trp Trp His Gly Val Leu Ala Trp Val Lys Glu 
            100                 105                 110         


Lys Val Val Ala Leu Val His Ala Val Gln Ala Leu Trp Lys Gln Phe 
        115                 120                 125             


Gln Ser Phe Cys Cys Ser Leu Ser Glu Leu Phe Met Ser Ser Phe Gln 
    130                 135                 140                 


Ser Tyr Gly Ala Pro Arg Gly Asp Lys Glu Glu Leu Thr Pro Gln Lys 
145                 150                 155                 160 


Cys Ser Glu Pro Gln Ser Ser Lys 
                165             


<210>  7068
<211>  168
<212>  PRT
<213>  Homo Sapiens

<400>  7068

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met Val Met Ser Ser Leu Ala Glu Leu Glu Asp Asp Phe Lys Glu 
            20                  25                  30          


Gly Tyr Leu Glu Thr Val Ala Ala Tyr Tyr Glu Glu Gln His Pro Glu 
        35                  40                  45              


Leu Thr Pro Leu Leu Glu Lys Glu Arg Asp Gly Leu Arg Cys Arg Gly 
    50                  55                  60                  


Asn Arg Ser Pro Val Pro Asp Val Glu Asp Pro Ala Thr Glu Glu Pro 
65                  70                  75                  80  


Gly Glu Ser Phe Cys Asp Lys Val Met Arg Trp Phe Gln Ala Met Leu 
                85                  90                  95      


Gln Arg Leu Gln Thr Trp Trp His Gly Val Leu Ala Trp Val Lys Glu 
            100                 105                 110         


Lys Val Val Ala Leu Val His Ala Val Gln Ala Leu Trp Lys Gln Phe 
        115                 120                 125             


Gln Ser Phe Cys Cys Ser Leu Ser Glu Leu Phe Met Ser Ser Phe Gln 
    130                 135                 140                 


Ser Tyr Gly Ala Pro Arg Gly Asp Lys Glu Glu Leu Thr Pro Gln Lys 
145                 150                 155                 160 


Cys Ser Glu Pro Gln Ser Ser Lys 
                165             


<210>  7069
<211>  168
<212>  PRT
<213>  Homo Sapiens

<400>  7069

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met Val Met Ser Ser Leu Ala Glu Leu Glu Asp Asp Phe Lys Glu 
            20                  25                  30          


Gly Tyr Leu Glu Thr Val Ala Ala Tyr Tyr Glu Glu Gln His Pro Glu 
        35                  40                  45              


Leu Thr Pro Leu Leu Glu Lys Glu Arg Asp Gly Leu Arg Cys Arg Gly 
    50                  55                  60                  


Asn Arg Ser Pro Val Pro Asp Val Glu Asp Pro Ala Thr Glu Glu Pro 
65                  70                  75                  80  


Gly Glu Ser Phe Cys Asp Lys Val Met Arg Trp Phe Gln Ala Met Leu 
                85                  90                  95      


Gln Arg Leu Gln Thr Trp Trp His Gly Val Leu Ala Trp Val Lys Glu 
            100                 105                 110         


Lys Val Val Ala Leu Val His Ala Val Gln Ala Leu Trp Lys Gln Phe 
        115                 120                 125             


Gln Ser Phe Cys Cys Ser Leu Ser Glu Leu Phe Met Ser Ser Phe Gln 
    130                 135                 140                 


Ser Tyr Gly Ala Pro Arg Gly Asp Lys Glu Glu Leu Thr Pro Gln Lys 
145                 150                 155                 160 


Cys Ser Glu Pro Gln Ser Ser Lys 
                165             


<210>  7070
<211>  148
<212>  PRT
<213>  Homo Sapiens

<400>  7070

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met Val Met Ser Ser Leu Ala Glu Leu Glu Glu Leu Thr Pro Leu 
            20                  25                  30          


Leu Glu Lys Glu Arg Asp Gly Leu Arg Cys Arg Gly Asn Arg Ser Pro 
        35                  40                  45              


Val Pro Asp Val Glu Asp Pro Ala Thr Glu Glu Pro Gly Glu Ser Phe 
    50                  55                  60                  


Cys Asp Lys Val Met Arg Trp Phe Gln Ala Met Leu Gln Arg Leu Gln 
65                  70                  75                  80  


Thr Trp Trp His Gly Val Leu Ala Trp Val Lys Glu Lys Val Val Ala 
                85                  90                  95      


Leu Val His Ala Val Gln Ala Leu Trp Lys Gln Phe Gln Ser Phe Cys 
            100                 105                 110         


Cys Ser Leu Ser Glu Leu Phe Met Ser Ser Phe Gln Ser Tyr Gly Ala 
        115                 120                 125             


Pro Arg Gly Asp Lys Glu Glu Leu Thr Pro Gln Lys Cys Ser Glu Pro 
    130                 135                 140                 


Gln Ser Ser Lys 
145             


<210>  7071
<211>  178
<212>  PRT
<213>  Homo Sapiens

<400>  7071

Met Lys Lys Leu Lys Ala Arg Met His Gln Ala Ile Glu Arg Phe Tyr 
1               5                   10                  15      


Asp Lys Met Gln Asn Ala Glu Ser Gly Arg Gly Gln Val Met Ser Ser 
            20                  25                  30          


Leu Ala Glu Leu Glu Asp Asp Phe Lys Glu Gly Tyr Leu Glu Thr Val 
        35                  40                  45              


Ala Ala Tyr Tyr Glu Glu Gln His Pro Glu Leu Thr Pro Leu Leu Glu 
    50                  55                  60                  


Lys Glu Arg Asp Gly Leu Arg Cys Arg Gly Asn Arg Ser Pro Val Pro 
65                  70                  75                  80  


Asp Val Glu Asp Pro Ala Thr Glu Glu Pro Gly Glu Ser Phe Cys Asp 
                85                  90                  95      


Lys Val Met Arg Trp Phe Gln Ala Met Leu Gln Arg Leu Gln Thr Trp 
            100                 105                 110         


Trp His Gly Val Leu Ala Trp Val Lys Glu Lys Val Val Ala Leu Val 
        115                 120                 125             


His Ala Val Gln Ala Leu Trp Lys Gln Phe Gln Ser Phe Cys Cys Ser 
    130                 135                 140                 


Leu Ser Glu Leu Phe Met Ser Ser Phe Gln Ser Tyr Gly Ala Pro Arg 
145                 150                 155                 160 


Gly Asp Lys Glu Glu Leu Thr Pro Gln Lys Cys Ser Glu Pro Gln Ser 
                165                 170                 175     


Ser Lys 
        


<210>  7072
<211>  54
<212>  PRT
<213>  Homo Sapiens

<400>  7072

Met Pro Arg Gly Phe Thr Trp Leu Arg Tyr Leu Gly Ile Phe Leu Gly 
1               5                   10                  15      


Val Ala Leu Gly Asn Glu Pro Leu Glu Met Trp Pro Leu Thr Gln Asn 
            20                  25                  30          


Glu Glu Cys Thr Val Thr Gly Phe Leu Arg Asp Lys Leu Gln Tyr Arg 
        35                  40                  45              


Ser Arg Leu Gln Tyr Met 
    50                  


<210>  7073
<211>  242
<212>  PRT
<213>  Homo Sapiens

<400>  7073

Met Pro Arg Gly Phe Thr Trp Leu Arg Tyr Leu Gly Ile Phe Leu Gly 
1               5                   10                  15      


Val Ala Leu Gly Asn Glu Pro Leu Glu Met Trp Pro Leu Thr Gln Asn 
            20                  25                  30          


Glu Glu Cys Thr Val Thr Gly Phe Leu Arg Asp Lys Leu Gln Tyr Arg 
        35                  40                  45              


Ser Arg Leu Gln Tyr Met Lys His Tyr Phe Pro Ile Asn Tyr Lys Ile 
    50                  55                  60                  


Ser Val Pro Tyr Glu Gly Val Phe Arg Ile Ala Asn Val Thr Arg Leu 
65                  70                  75                  80  


Gln Arg Ala Gln Val Ser Glu Arg Glu Leu Arg Tyr Leu Trp Val Leu 
                85                  90                  95      


Val Ser Leu Ser Ala Thr Glu Ser Val Gln Asp Val Leu Leu Glu Gly 
            100                 105                 110         


His Pro Ser Trp Lys Tyr Leu Gln Glu Val Glu Thr Leu Leu Leu Asn 
        115                 120                 125             


Val Gln Gln Gly Leu Thr Asp Val Glu Val Ser Pro Lys Val Glu Ser 
    130                 135                 140                 


Val Leu Ser Leu Leu Asn Ala Pro Gly Pro Asn Leu Lys Leu Val Arg 
145                 150                 155                 160 


Pro Lys Ala Leu Leu Asp Asn Cys Phe Arg Val Met Glu Leu Leu Tyr 
                165                 170                 175     


Cys Ser Cys Cys Lys Gln Ser Ser Val Leu Asn Trp Gln Asp Cys Glu 
            180                 185                 190         


Val Pro Ser Pro Gln Ser Cys Ser Pro Glu Pro Ser Leu Gln Tyr Ala 
        195                 200                 205             


Ala Thr Gln Leu Tyr Pro Pro Pro Pro Trp Ser Pro Ser Ser Pro Pro 
    210                 215                 220                 


His Ser Thr Gly Ser Val Arg Pro Val Arg Ala Gln Gly Glu Gly Leu 
225                 230                 235                 240 


Leu Pro 
        


<210>  7074
<211>  242
<212>  PRT
<213>  Homo Sapiens

<400>  7074

Met Pro Arg Gly Phe Thr Trp Leu Arg Tyr Leu Gly Ile Phe Leu Gly 
1               5                   10                  15      


Val Ala Leu Gly Asn Glu Pro Leu Glu Met Trp Pro Leu Thr Gln Asn 
            20                  25                  30          


Glu Glu Cys Thr Val Thr Gly Phe Leu Arg Asp Lys Leu Gln Tyr Arg 
        35                  40                  45              


Ser Arg Leu Gln Tyr Met Lys His Tyr Phe Pro Ile Asn Tyr Lys Ile 
    50                  55                  60                  


Ser Val Pro Tyr Glu Gly Val Phe Arg Ile Ala Asn Val Thr Arg Leu 
65                  70                  75                  80  


Gln Arg Ala Gln Val Ser Glu Arg Glu Leu Arg Tyr Leu Trp Val Leu 
                85                  90                  95      


Val Ser Leu Ser Ala Thr Glu Ser Val Gln Asp Val Leu Leu Glu Gly 
            100                 105                 110         


His Pro Ser Trp Lys Tyr Leu Gln Glu Val Glu Thr Leu Leu Leu Asn 
        115                 120                 125             


Val Gln Gln Gly Leu Thr Asp Val Glu Val Ser Pro Lys Val Glu Ser 
    130                 135                 140                 


Val Leu Ser Leu Leu Asn Ala Pro Gly Pro Asn Leu Lys Leu Val Arg 
145                 150                 155                 160 


Pro Lys Ala Leu Leu Asp Asn Cys Phe Arg Val Met Glu Leu Leu Tyr 
                165                 170                 175     


Cys Ser Cys Cys Lys Gln Ser Ser Val Leu Asn Trp Gln Asp Cys Glu 
            180                 185                 190         


Val Pro Ser Pro Gln Ser Cys Ser Pro Glu Pro Ser Leu Gln Tyr Ala 
        195                 200                 205             


Ala Thr Gln Leu Tyr Pro Pro Pro Pro Trp Ser Pro Ser Ser Pro Pro 
    210                 215                 220                 


His Ser Thr Gly Ser Val Arg Pro Val Arg Ala Gln Gly Glu Gly Leu 
225                 230                 235                 240 


Leu Pro 
        


<210>  7075
<211>  217
<212>  PRT
<213>  Homo Sapiens

<400>  7075

Met Trp Pro Leu Thr Gln Asn Glu Glu Cys Thr Val Thr Gly Phe Leu 
1               5                   10                  15      


Arg Asp Lys Leu Gln Tyr Arg Ser Arg Leu Gln Tyr Met Lys His Tyr 
            20                  25                  30          


Phe Pro Ile Asn Tyr Lys Ile Ser Val Pro Tyr Glu Gly Val Phe Arg 
        35                  40                  45              


Ile Ala Asn Val Thr Arg Leu Gln Arg Ala Gln Val Ser Glu Arg Glu 
    50                  55                  60                  


Leu Arg Tyr Leu Trp Val Leu Val Ser Leu Ser Ala Thr Glu Ser Val 
65                  70                  75                  80  


Gln Asp Val Leu Leu Glu Gly His Pro Ser Trp Lys Tyr Leu Gln Glu 
                85                  90                  95      


Val Glu Thr Leu Leu Leu Asn Val Gln Gln Gly Leu Thr Asp Val Glu 
            100                 105                 110         


Val Ser Pro Lys Val Glu Ser Val Leu Ser Leu Leu Asn Ala Pro Gly 
        115                 120                 125             


Pro Asn Leu Lys Leu Val Arg Pro Lys Ala Leu Leu Asp Asn Cys Phe 
    130                 135                 140                 


Arg Val Met Glu Leu Leu Tyr Cys Ser Cys Cys Lys Gln Ser Ser Val 
145                 150                 155                 160 


Leu Asn Trp Gln Asp Cys Glu Val Pro Ser Pro Gln Ser Cys Ser Pro 
                165                 170                 175     


Glu Pro Ser Leu Gln Tyr Ala Ala Thr Gln Leu Tyr Pro Pro Pro Pro 
            180                 185                 190         


Trp Ser Pro Ser Ser Pro Pro His Ser Thr Gly Ser Val Arg Pro Val 
        195                 200                 205             


Arg Ala Gln Gly Glu Gly Leu Leu Pro 
    210                 215         


<210>  7076
<211>  378
<212>  PRT
<213>  Homo Sapiens

<400>  7076

Met Val Leu Leu Trp Leu Thr Leu Leu Leu Ile Ala Leu Pro Cys Leu 
1               5                   10                  15      


Leu Gln Thr Lys Glu Asp Pro Asn Pro Pro Ile Thr Asn Leu Arg Met 
            20                  25                  30          


Lys Ala Lys Ala Gln Gln Leu Thr Trp Asp Leu Asn Arg Asn Val Thr 
        35                  40                  45              


Asp Ile Glu Cys Val Lys Asp Ala Asp Tyr Ser Met Pro Ala Val Asn 
    50                  55                  60                  


Asn Ser Tyr Cys Gln Phe Gly Ala Ile Ser Leu Cys Glu Val Thr Asn 
65                  70                  75                  80  


Tyr Thr Val Arg Val Ala Asn Pro Pro Phe Ser Thr Trp Ile Leu Phe 
                85                  90                  95      


Pro Glu Asn Ser Gly Lys Pro Trp Ala Gly Ala Glu Asn Leu Thr Cys 
            100                 105                 110         


Trp Ile His Asp Val Asp Phe Leu Ser Cys Ser Trp Ala Val Gly Pro 
        115                 120                 125             


Gly Ala Pro Ala Asp Val Gln Tyr Asp Leu Tyr Leu Asn Val Ala Asn 
    130                 135                 140                 


Arg Arg Gln Gln Tyr Glu Cys Leu His Tyr Lys Thr Asp Ala Gln Gly 
145                 150                 155                 160 


Thr Arg Ile Gly Cys Arg Phe Asp Asp Ile Ser Arg Leu Ser Ser Gly 
                165                 170                 175     


Ser Gln Ser Ser His Ile Leu Val Arg Gly Arg Ser Ala Ala Phe Gly 
            180                 185                 190         


Ile Pro Cys Thr Asp Lys Phe Val Val Phe Ser Gln Ile Glu Ile Leu 
        195                 200                 205             


Thr Pro Pro Asn Met Thr Ala Lys Cys Asn Lys Thr His Ser Phe Met 
    210                 215                 220                 


His Trp Lys Met Arg Ser His Phe Asn Arg Lys Phe Arg Tyr Glu Leu 
225                 230                 235                 240 


Gln Ile Gln Lys Arg Met Gln Pro Val Ile Thr Glu Gln Val Arg Asp 
                245                 250                 255     


Arg Thr Ser Phe Gln Leu Leu Asn Pro Gly Thr Tyr Thr Val Gln Ile 
            260                 265                 270         


Arg Ala Arg Glu Arg Val Tyr Glu Phe Leu Ser Ala Trp Ser Thr Pro 
        275                 280                 285             


Gln Arg Phe Glu Cys Asp Gln Glu Glu Gly Ala Asn Thr Arg Ala Trp 
    290                 295                 300                 


Arg Thr Ser Leu Leu Ile Ala Leu Gly Thr Leu Leu Ala Leu Val Cys 
305                 310                 315                 320 


Val Phe Val Ile Cys Arg Arg Tyr Leu Val Met Gln Arg Leu Phe Pro 
                325                 330                 335     


Arg Ile Pro His Met Lys Asp Pro Ile Gly Asp Ser Phe Gln Asn Asp 
            340                 345                 350         


Lys Leu Val Val Trp Glu Ala Gly Lys Ala Gly Leu Glu Glu Cys Leu 
        355                 360                 365             


Val Thr Glu Val Gln Val Val Gln Lys Thr 
    370                 375             


<210>  7077
<211>  164
<212>  PRT
<213>  Homo Sapiens

<400>  7077

Met Val Leu Leu Trp Leu Thr Leu Leu Leu Ile Ala Leu Pro Cys Leu 
1               5                   10                  15      


Leu Gln Thr Lys Glu Gly Gly Lys Pro Trp Ala Gly Ala Glu Asn Leu 
            20                  25                  30          


Thr Cys Trp Ile His Asp Val Asp Phe Leu Ser Cys Ser Trp Ala Val 
        35                  40                  45              


Gly Pro Gly Ala Pro Ala Asp Val Gln Tyr Asp Leu Tyr Leu Asn Val 
    50                  55                  60                  


Ala Asn Arg Arg Gln Gln Tyr Glu Cys Leu His Tyr Lys Thr Asp Ala 
65                  70                  75                  80  


Gln Gly Thr Arg Ile Gly Cys Arg Phe Asp Asp Ile Ser Arg Leu Ser 
                85                  90                  95      


Ser Gly Ser Gln Ser Ser His Ile Leu Val Arg Gly Arg Ser Ala Ala 
            100                 105                 110         


Phe Gly Ile Pro Cys Thr Asp Lys Phe Val Val Phe Ser Gln Ile Glu 
        115                 120                 125             


Ile Leu Thr Pro Pro Asn Met Thr Ala Lys Cys Asn Lys Thr His Ser 
    130                 135                 140                 


Phe Met His Trp Lys Met Arg Ser His Phe Asn Arg Lys Phe Arg Tyr 
145                 150                 155                 160 


Glu Leu Gln Ile 
                


<210>  7078
<211>  300
<212>  PRT
<213>  Homo Sapiens

<400>  7078

Met Val Leu Leu Trp Leu Thr Leu Leu Leu Ile Ala Leu Pro Cys Leu 
1               5                   10                  15      


Leu Gln Thr Lys Glu Gly Gly Lys Pro Trp Ala Gly Ala Glu Asn Leu 
            20                  25                  30          


Thr Cys Trp Ile His Asp Val Asp Phe Leu Ser Cys Ser Trp Ala Val 
        35                  40                  45              


Gly Pro Gly Ala Pro Ala Asp Val Gln Tyr Asp Leu Tyr Leu Asn Val 
    50                  55                  60                  


Ala Asn Arg Arg Gln Gln Tyr Glu Cys Leu His Tyr Lys Thr Asp Ala 
65                  70                  75                  80  


Gln Gly Thr Arg Ile Gly Cys Arg Phe Asp Asp Ile Ser Arg Leu Ser 
                85                  90                  95      


Ser Gly Ser Gln Ser Ser His Ile Leu Val Arg Gly Arg Ser Ala Ala 
            100                 105                 110         


Phe Gly Ile Pro Cys Thr Asp Lys Phe Val Val Phe Ser Gln Ile Glu 
        115                 120                 125             


Ile Leu Thr Pro Pro Asn Met Thr Ala Lys Cys Asn Lys Thr His Ser 
    130                 135                 140                 


Phe Met His Trp Lys Met Arg Ser His Phe Asn Arg Lys Phe Arg Tyr 
145                 150                 155                 160 


Glu Leu Gln Ile Gln Lys Arg Met Gln Pro Val Ile Thr Glu Gln Val 
                165                 170                 175     


Arg Asp Arg Thr Ser Phe Gln Leu Leu Asn Pro Gly Thr Tyr Thr Val 
            180                 185                 190         


Gln Ile Arg Ala Arg Glu Arg Val Tyr Glu Phe Leu Ser Ala Trp Ser 
        195                 200                 205             


Thr Pro Gln Arg Phe Glu Cys Asp Gln Glu Glu Gly Ala Asn Thr Arg 
    210                 215                 220                 


Ala Trp Arg Thr Ser Leu Leu Ile Ala Leu Gly Thr Leu Leu Ala Leu 
225                 230                 235                 240 


Val Cys Val Phe Val Ile Cys Arg Arg Tyr Leu Val Met Gln Arg Leu 
                245                 250                 255     


Phe Pro Arg Ile Pro His Met Lys Asp Pro Ile Gly Asp Ser Phe Gln 
            260                 265                 270         


Asn Asp Lys Leu Val Val Trp Glu Ala Gly Lys Ala Gly Leu Glu Glu 
        275                 280                 285             


Cys Leu Val Thr Glu Val Gln Val Val Gln Lys Thr 
    290                 295                 300 


<210>  7079
<211>  137
<212>  PRT
<213>  Homo Sapiens

<400>  7079

Met Gly Leu Thr Ser Gln Leu Leu Pro Pro Leu Phe Phe Leu Leu Ala 
1               5                   10                  15      


Cys Ala Gly Asn Phe Val His Gly His Lys Cys Asp Ile Thr Leu Gln 
            20                  25                  30          


Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Asn Thr Thr 
        35                  40                  45              


Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 
    50                  55                  60                  


Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 
65                  70                  75                  80  


Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 
                85                  90                  95      


Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 
            100                 105                 110         


Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 
        115                 120                 125             


Arg Glu Lys Tyr Ser Lys Cys Ser Ser 
    130                 135         


<210>  7080
<211>  153
<212>  PRT
<213>  Homo Sapiens

<400>  7080

Met Gly Leu Thr Ser Gln Leu Leu Pro Pro Leu Phe Phe Leu Leu Ala 
1               5                   10                  15      


Cys Ala Gly Asn Phe Val His Gly His Lys Cys Asp Ile Thr Leu Gln 
            20                  25                  30          


Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys 
        35                  40                  45              


Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr 
    50                  55                  60                  


Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 
65                  70                  75                  80  


Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 
                85                  90                  95      


Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 
            100                 105                 110         


Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 
        115                 120                 125             


Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 
    130                 135                 140                 


Arg Glu Lys Tyr Ser Lys Cys Ser Ser 
145                 150             


<210>  7081
<211>  136
<212>  PRT
<213>  Homo Sapiens

<400>  7081

Met Gly Leu Thr Ser Gln Leu Leu Pro Pro Leu Phe Phe Leu Leu Ala 
1               5                   10                  15      


Cys Ala Gly Asn Phe Val His Gly His Lys Cys Asp Ile Thr Leu Gln 
            20                  25                  30          


Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys 
        35                  40                  45              


Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Gln His Ala 
    50                  55                  60                  


Cys Leu Pro Thr Ser Arg His Thr Gly Thr Ile Cys Arg Pro Pro Ser 
65                  70                  75                  80  


Ala Arg Val Pro Ser Thr Ser Thr Arg Leu Gln Ser Pro Glu Arg Thr 
                85                  90                  95      


Gln Leu Arg Arg Lys Pro Ser Ala Gly Leu Arg Leu Cys Ser Gly Ser 
            100                 105                 110         


Ser Thr Ala Thr Met Arg Arg Thr Leu Ala Ala Trp Val Arg Leu His 
        115                 120                 125             


Ser Ser Ser Thr Gly Thr Ser Ser 
    130                 135     


<210>  7082
<211>  32
<212>  PRT
<213>  Homo Sapiens

<400>  7082

Met Ala Pro Leu Ala Leu His Leu Leu Val Leu Val Pro Ile Leu Leu 
1               5                   10                  15      


Ser Leu Val Ala Ser Gln Asp Trp Lys Ala Glu Arg Ser Gln Asp Pro 
            20                  25                  30          


<210>  7083
<211>  150
<212>  PRT
<213>  Homo Sapiens

<400>  7083

Met Ala Pro Leu Ala Leu His Leu Leu Val Leu Val Pro Ile Leu Leu 
1               5                   10                  15      


Ser Leu Val Ala Ser Gln Asp Trp Lys Ala Glu Arg Ser Gln Asp Pro 
            20                  25                  30          


Phe Glu Lys Cys Met Gln Asp Pro Asp Tyr Glu Gln Leu Leu Lys Val 
        35                  40                  45              


Thr Ile Leu Glu Ala Asp Asn Arg Ile Gly Gly Arg Ile Phe Thr Tyr 
    50                  55                  60                  


Arg Asp Gln Asn Thr Gly Trp Ile Gly Glu Leu Gly Ala Met Arg Met 
65                  70                  75                  80  


Pro Ser Ser His Arg Ile Leu His Lys Leu Cys Gln Gly Leu Gly Leu 
                85                  90                  95      


Asn Leu Thr Lys Phe Thr Gln Tyr Asp Lys Asn Thr Trp Thr Glu Val 
            100                 105                 110         


His Glu Val Lys Leu Arg Asn Tyr Val Val Glu Lys Val Pro Glu Lys 
        115                 120                 125             


Leu Gly Tyr Ala Leu Arg Pro Gln Glu Lys Gly His Ser Pro Glu Asp 
    130                 135                 140                 


Ile Tyr Gln Met Ala Leu 
145                 150 


<210>  7084
<211>  71
<212>  PRT
<213>  Homo Sapiens

<400>  7084

Met Ala Pro Leu Ala Leu His Leu Leu Val Leu Val Pro Ile Leu Leu 
1               5                   10                  15      


Ser Leu Val Ala Ser Gln Asp Trp Lys Ala Glu Arg Ser Gln Asp Pro 
            20                  25                  30          


Phe Glu Lys Cys Met Gln Asp Pro Asp Tyr Glu Gln Leu Leu Lys Val 
        35                  40                  45              


Val Thr Trp Gly Leu Asn Arg Thr Leu Lys Pro Gln Arg Val Ile Val 
    50                  55                  60                  


Val Gly Ala Gly Val Ala Gly 
65                  70      


<210>  7085
<211>  567
<212>  PRT
<213>  Homo Sapiens

<400>  7085

Met Ala Pro Leu Ala Leu His Leu Leu Val Leu Val Pro Ile Leu Leu 
1               5                   10                  15      


Ser Leu Val Ala Ser Gln Asp Trp Lys Ala Glu Arg Ser Gln Asp Pro 
            20                  25                  30          


Phe Glu Lys Cys Met Gln Asp Pro Asp Tyr Glu Gln Leu Leu Lys Val 
        35                  40                  45              


Val Thr Trp Gly Leu Asn Arg Thr Leu Lys Pro Gln Arg Val Ile Val 
    50                  55                  60                  


Val Gly Ala Gly Val Ala Gly Leu Val Ala Ala Lys Val Leu Ser Asp 
65                  70                  75                  80  


Ala Gly His Lys Val Thr Ile Leu Glu Ala Asp Asn Arg Ile Gly Gly 
                85                  90                  95      


Arg Ile Phe Thr Tyr Arg Asp Gln Asn Thr Gly Trp Ile Gly Glu Leu 
            100                 105                 110         


Gly Ala Met Arg Met Pro Ser Ser His Arg Ile Leu His Lys Leu Cys 
        115                 120                 125             


Gln Gly Leu Gly Leu Asn Leu Thr Lys Phe Thr Gln Tyr Asp Lys Asn 
    130                 135                 140                 


Thr Trp Thr Glu Val His Glu Val Lys Leu Arg Asn Tyr Val Val Glu 
145                 150                 155                 160 


Lys Val Pro Glu Lys Leu Gly Tyr Ala Leu Arg Pro Gln Glu Lys Gly 
                165                 170                 175     


His Ser Pro Glu Asp Ile Tyr Gln Met Ala Leu Asn Gln Ala Leu Lys 
            180                 185                 190         


Asp Leu Lys Ala Leu Gly Cys Arg Lys Ala Met Lys Lys Phe Glu Arg 
        195                 200                 205             


His Thr Leu Leu Glu Tyr Leu Leu Gly Glu Gly Asn Leu Ser Arg Pro 
    210                 215                 220                 


Ala Val Gln Leu Leu Gly Asp Val Met Ser Glu Asp Gly Phe Phe Tyr 
225                 230                 235                 240 


Leu Ser Phe Ala Glu Ala Leu Arg Ala His Ser Cys Leu Ser Asp Arg 
                245                 250                 255     


Leu Gln Tyr Ser Arg Ile Val Gly Gly Trp Asp Leu Leu Pro Arg Ala 
            260                 265                 270         


Leu Leu Ser Ser Leu Ser Gly Leu Val Leu Leu Asn Ala Pro Val Val 
        275                 280                 285             


Ala Met Thr Gln Gly Pro His Asp Val His Val Gln Ile Glu Thr Ser 
    290                 295                 300                 


Pro Pro Ala Arg Asn Leu Lys Val Leu Lys Ala Asp Val Val Leu Leu 
305                 310                 315                 320 


Thr Ala Ser Gly Pro Ala Val Lys Arg Ile Thr Phe Ser Pro Pro Leu 
                325                 330                 335     


Pro Arg His Met Gln Glu Ala Leu Arg Arg Leu His Tyr Val Pro Ala 
            340                 345                 350         


Thr Lys Val Phe Leu Ser Phe Arg Arg Pro Phe Trp Arg Glu Glu His 
        355                 360                 365             


Ile Glu Gly Gly His Ser Asn Thr Asp Arg Pro Ser Arg Met Ile Phe 
    370                 375                 380                 


Tyr Pro Pro Pro Arg Glu Gly Ala Leu Leu Leu Ala Ser Tyr Thr Trp 
385                 390                 395                 400 


Ser Asp Ala Ala Ala Ala Phe Ala Gly Leu Ser Arg Glu Glu Ala Leu 
                405                 410                 415     


Arg Leu Ala Leu Asp Asp Val Ala Ala Leu His Gly Pro Val Val Arg 
            420                 425                 430         


Gln Leu Trp Asp Gly Thr Gly Val Val Lys Arg Trp Ala Glu Asp Gln 
        435                 440                 445             


His Ser Gln Gly Gly Phe Val Val Gln Pro Pro Ala Leu Trp Gln Thr 
    450                 455                 460                 


Glu Lys Asp Asp Trp Thr Val Pro Tyr Gly Arg Ile Tyr Phe Ala Gly 
465                 470                 475                 480 


Glu His Thr Ala Tyr Pro His Gly Trp Val Glu Thr Ala Val Lys Ser 
                485                 490                 495     


Ala Leu Arg Ala Ala Ile Lys Ile Asn Ser Arg Lys Gly Pro Ala Ser 
            500                 505                 510         


Asp Thr Ala Ser Pro Glu Gly His Ala Ser Asp Met Glu Gly Gln Gly 
        515                 520                 525             


His Val His Gly Val Ala Ser Ser Pro Ser His Asp Leu Ala Lys Glu 
    530                 535                 540                 


Glu Gly Ser His Pro Pro Val Gln Gly Gln Leu Ser Leu Gln Asn Thr 
545                 550                 555                 560 


Thr His Thr Arg Thr Ser His 
                565         


<210>  7086
<211>  82
<212>  PRT
<213>  Homo Sapiens

<400>  7086

Met Pro Asn Asp Asp Phe Cys Pro Gly Leu Thr Ile Lys Ala Met Gly 
1               5                   10                  15      


Ala Glu Arg Ala Pro Gln Arg Gln Pro Cys Asn Thr Ile Ser His Arg 
            20                  25                  30          


Glu Ser Trp Pro His Trp Pro Cys Thr Ser Ser Ser Ser Ser Pro Ser 
        35                  40                  45              


Ser Ser Ala Trp Trp Pro Pro Arg Thr Gly Arg Leu Asn Ala Ala Lys 
    50                  55                  60                  


Thr Pro Ser Arg Asn Ala Cys Arg Ile Leu Thr Met Ser Ser Cys Ser 
65                  70                  75                  80  


Arg Trp 
        


<210>  7087
<211>  106
<212>  PRT
<213>  Homo Sapiens

<400>  7087

Met Pro Asn Asp Asp Phe Cys Pro Gly Leu Thr Ile Lys Ala Met Gly 
1               5                   10                  15      


Ala Glu Arg Ala Pro Gln Arg Gln Pro Cys Thr Leu His Leu Leu Val 
            20                  25                  30          


Leu Val Pro Ile Leu Leu Ser Leu Val Ala Ser Gln Asp Trp Lys Ala 
        35                  40                  45              


Glu Arg Ser Gln Asp Pro Phe Glu Lys Cys Met Gln Asp Pro Asp Tyr 
    50                  55                  60                  


Glu Gln Leu Leu Lys Val Val Thr Trp Gly Leu Asn Arg Thr Leu Lys 
65                  70                  75                  80  


Pro Gln Arg Val Ile Val Val Gly Ala Gly Val Ala Gly Leu Val Ala 
                85                  90                  95      


Ala Lys Val Leu Ser Asp Ala Gly His Lys 
            100                 105     


<210>  7088
<211>  589
<212>  PRT
<213>  Homo Sapiens

<400>  7088

Met Pro Asn Asp Asp Phe Cys Pro Gly Leu Thr Ile Lys Ala Met Gly 
1               5                   10                  15      


Ala Glu Arg Ala Pro Gln Arg Gln Pro Cys Thr Leu His Leu Leu Val 
            20                  25                  30          


Leu Val Pro Ile Leu Leu Ser Leu Val Ala Ser Gln Asp Trp Lys Ala 
        35                  40                  45              


Glu Arg Ser Gln Asp Pro Phe Glu Lys Cys Met Gln Asp Pro Asp Tyr 
    50                  55                  60                  


Glu Gln Leu Leu Lys Val Val Thr Trp Gly Leu Asn Arg Thr Leu Lys 
65                  70                  75                  80  


Pro Gln Arg Val Ile Val Val Gly Ala Gly Val Ala Gly Leu Val Ala 
                85                  90                  95      


Ala Lys Val Leu Ser Asp Ala Gly His Lys Val Thr Ile Leu Glu Ala 
            100                 105                 110         


Asp Asn Arg Ile Gly Gly Arg Ile Phe Thr Tyr Arg Asp Gln Asn Thr 
        115                 120                 125             


Gly Trp Ile Gly Glu Leu Gly Ala Met Arg Met Pro Ser Ser His Arg 
    130                 135                 140                 


Ile Leu His Lys Leu Cys Gln Gly Leu Gly Leu Asn Leu Thr Lys Phe 
145                 150                 155                 160 


Thr Gln Tyr Asp Lys Asn Thr Trp Thr Glu Val His Glu Val Lys Leu 
                165                 170                 175     


Arg Asn Tyr Val Val Glu Lys Val Pro Glu Lys Leu Gly Tyr Ala Leu 
            180                 185                 190         


Arg Pro Gln Glu Lys Gly His Ser Pro Glu Asp Ile Tyr Gln Met Ala 
        195                 200                 205             


Leu Asn Gln Ala Leu Lys Asp Leu Lys Ala Leu Gly Cys Arg Lys Ala 
    210                 215                 220                 


Met Lys Lys Phe Glu Arg His Thr Leu Leu Glu Tyr Leu Leu Gly Glu 
225                 230                 235                 240 


Gly Asn Leu Ser Arg Pro Ala Val Gln Leu Leu Gly Asp Val Met Ser 
                245                 250                 255     


Glu Asp Gly Phe Phe Tyr Leu Ser Phe Ala Glu Ala Leu Arg Ala His 
            260                 265                 270         


Ser Cys Leu Ser Asp Arg Leu Gln Tyr Ser Arg Ile Val Gly Gly Trp 
        275                 280                 285             


Asp Leu Leu Pro Arg Ala Leu Leu Ser Ser Leu Ser Gly Leu Val Leu 
    290                 295                 300                 


Leu Asn Ala Pro Val Val Ala Met Thr Gln Gly Pro His Asp Val His 
305                 310                 315                 320 


Val Gln Ile Glu Thr Ser Pro Pro Ala Arg Asn Leu Lys Val Leu Lys 
                325                 330                 335     


Ala Asp Val Val Leu Leu Thr Ala Ser Gly Pro Ala Val Lys Arg Ile 
            340                 345                 350         


Thr Phe Ser Pro Pro Leu Pro Arg His Met Gln Glu Ala Leu Arg Arg 
        355                 360                 365             


Leu His Tyr Val Pro Ala Thr Lys Val Phe Leu Ser Phe Arg Arg Pro 
    370                 375                 380                 


Phe Trp Arg Glu Glu His Ile Glu Gly Gly His Ser Asn Thr Asp Arg 
385                 390                 395                 400 


Pro Ser Arg Met Ile Phe Tyr Pro Pro Pro Arg Glu Gly Ala Leu Leu 
                405                 410                 415     


Leu Ala Ser Tyr Thr Trp Ser Asp Ala Ala Ala Ala Phe Ala Gly Leu 
            420                 425                 430         


Ser Arg Glu Glu Ala Leu Arg Leu Ala Leu Asp Asp Val Ala Ala Leu 
        435                 440                 445             


His Gly Pro Val Val Arg Gln Leu Trp Asp Gly Thr Gly Val Val Lys 
    450                 455                 460                 


Arg Trp Ala Glu Asp Gln His Ser Gln Gly Gly Phe Val Val Gln Pro 
465                 470                 475                 480 


Pro Ala Leu Trp Gln Thr Glu Lys Asp Asp Trp Thr Val Pro Tyr Gly 
                485                 490                 495     


Arg Ile Tyr Phe Ala Gly Glu His Thr Ala Tyr Pro His Gly Trp Val 
            500                 505                 510         


Glu Thr Ala Val Lys Ser Ala Leu Arg Ala Ala Ile Lys Ile Asn Ser 
        515                 520                 525             


Arg Lys Gly Pro Ala Ser Asp Thr Ala Ser Pro Glu Gly His Ala Ser 
    530                 535                 540                 


Asp Met Glu Gly Gln Gly His Val His Gly Val Ala Ser Ser Pro Ser 
545                 550                 555                 560 


His Asp Leu Ala Lys Glu Glu Gly Ser His Pro Pro Val Gln Gly Gln 
                565                 570                 575     


Leu Ser Leu Gln Asn Thr Thr His Thr Arg Thr Ser His 
            580                 585                 


<210>  7089
<211>  589
<212>  PRT
<213>  Homo Sapiens

<400>  7089

Met Pro Asn Asp Asp Phe Cys Pro Gly Leu Thr Ile Lys Ala Met Gly 
1               5                   10                  15      


Ala Glu Arg Ala Pro Gln Arg Gln Pro Cys Thr Leu His Leu Leu Val 
            20                  25                  30          


Leu Val Pro Ile Leu Leu Ser Leu Val Ala Ser Gln Asp Trp Lys Ala 
        35                  40                  45              


Glu Arg Ser Gln Asp Pro Phe Glu Lys Cys Met Gln Asp Pro Asp Tyr 
    50                  55                  60                  


Glu Gln Leu Leu Lys Val Val Thr Trp Gly Leu Asn Arg Thr Leu Lys 
65                  70                  75                  80  


Pro Gln Arg Val Ile Val Val Gly Ala Gly Val Ala Gly Leu Val Ala 
                85                  90                  95      


Ala Lys Val Leu Ser Asp Ala Gly His Lys Val Thr Ile Leu Glu Ala 
            100                 105                 110         


Asp Asn Arg Ile Gly Gly Arg Ile Phe Thr Tyr Arg Asp Gln Asn Thr 
        115                 120                 125             


Gly Trp Ile Gly Glu Leu Gly Ala Met Arg Met Pro Ser Ser His Arg 
    130                 135                 140                 


Ile Leu His Lys Leu Cys Gln Gly Leu Gly Leu Asn Leu Thr Lys Phe 
145                 150                 155                 160 


Thr Gln Tyr Asp Lys Asn Thr Trp Thr Glu Val His Glu Val Lys Leu 
                165                 170                 175     


Arg Asn Tyr Val Val Glu Lys Val Pro Glu Lys Leu Gly Tyr Ala Leu 
            180                 185                 190         


Arg Pro Gln Glu Lys Gly His Ser Pro Glu Asp Ile Tyr Gln Met Ala 
        195                 200                 205             


Leu Asn Gln Ala Leu Lys Asp Leu Lys Ala Leu Gly Cys Arg Lys Ala 
    210                 215                 220                 


Met Lys Lys Phe Glu Arg His Thr Leu Leu Glu Tyr Leu Leu Gly Glu 
225                 230                 235                 240 


Gly Asn Leu Ser Arg Pro Ala Val Gln Leu Leu Gly Asp Val Met Ser 
                245                 250                 255     


Glu Asp Gly Phe Phe Tyr Leu Ser Phe Ala Glu Ala Leu Arg Ala His 
            260                 265                 270         


Ser Cys Leu Ser Asp Arg Leu Gln Tyr Ser Arg Ile Val Gly Gly Trp 
        275                 280                 285             


Asp Leu Leu Pro Arg Ala Leu Leu Ser Ser Leu Ser Gly Leu Val Leu 
    290                 295                 300                 


Leu Asn Ala Pro Val Val Ala Met Thr Gln Gly Pro His Asp Val His 
305                 310                 315                 320 


Val Gln Ile Glu Thr Ser Pro Pro Ala Arg Asn Leu Lys Val Leu Lys 
                325                 330                 335     


Ala Asp Val Val Leu Leu Thr Ala Ser Gly Pro Ala Val Lys Arg Ile 
            340                 345                 350         


Thr Phe Ser Pro Pro Leu Pro Arg His Met Gln Glu Ala Leu Arg Arg 
        355                 360                 365             


Leu His Tyr Val Pro Ala Thr Lys Val Phe Leu Ser Phe Arg Arg Pro 
    370                 375                 380                 


Phe Trp Arg Glu Glu His Ile Glu Gly Gly His Ser Asn Thr Asp Arg 
385                 390                 395                 400 


Pro Ser Arg Met Ile Phe Tyr Pro Pro Pro Arg Glu Gly Ala Leu Leu 
                405                 410                 415     


Leu Ala Ser Tyr Thr Trp Ser Asp Ala Ala Ala Ala Phe Ala Gly Leu 
            420                 425                 430         


Ser Arg Glu Glu Ala Leu Arg Leu Ala Leu Asp Asp Val Ala Ala Leu 
        435                 440                 445             


His Gly Pro Val Val Arg Gln Leu Trp Asp Gly Thr Gly Val Val Lys 
    450                 455                 460                 


Arg Trp Ala Glu Asp Gln His Ser Gln Gly Gly Phe Val Val Gln Pro 
465                 470                 475                 480 


Pro Ala Leu Trp Gln Thr Glu Lys Asp Asp Trp Thr Val Pro Tyr Gly 
                485                 490                 495     


Arg Ile Tyr Phe Ala Gly Glu His Thr Ala Tyr Pro His Gly Trp Val 
            500                 505                 510         


Glu Thr Ala Val Lys Ser Ala Leu Arg Ala Ala Ile Lys Ile Asn Ser 
        515                 520                 525             


Arg Lys Gly Pro Ala Ser Asp Thr Ala Ser Pro Glu Gly His Ala Ser 
    530                 535                 540                 


Asp Met Glu Gly Gln Gly His Val His Gly Val Ala Ser Ser Pro Ser 
545                 550                 555                 560 


His Asp Leu Ala Lys Glu Glu Gly Ser His Pro Pro Val Gln Gly Gln 
                565                 570                 575     


Leu Ser Leu Gln Asn Thr Thr His Thr Arg Thr Ser His 
            580                 585                 


<210>  7090
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  7090

Met Gly Trp Leu Cys Ser Gly Leu Leu Phe 
1               5                   10  


<210>  7091
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  7091

Met Gly Trp Leu Cys Ser Gly Leu Leu Phe Pro Val Ser Cys Leu Val 
1               5                   10                  15      


Leu Leu Gln Val Ala Ser Ser Gly Leu Phe Arg Met Pro Cys Gly Glu 
            20                  25                  30          


Arg Lys Arg Val Glu Ala Arg Arg Ser Gly Gly Arg Ser Gly Val Glu 
        35                  40                  45              


Glu Met Arg Gly Ser Gly Ser Leu Trp Glu Val Asp Leu Arg Thr Asp 
    50                  55                  60                  


Trp Asn 
65      


<210>  7092
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  7092

Met Gly Trp Leu Cys Ser Gly Leu Leu Phe Pro Val Ser Cys Leu Val 
1               5                   10                  15      


Leu Leu Gln Val Ala Ser Ser Gly Leu Phe Arg Met Pro Cys Gly Glu 
            20                  25                  30          


Arg Lys Arg Val Glu Ala Arg Arg Ser Gly Gly Arg Ser Gly Val Glu 
        35                  40                  45              


Glu Met Arg Gly Ser Gly Ser Leu Trp Glu Val Asp Leu Arg Thr Asp 
    50                  55                  60                  


Trp Asn 
65      


<210>  7093
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  7093

Met Gly Trp Leu Cys Ser Gly Leu Leu Phe Pro Val Ser Cys Leu Val 
1               5                   10                  15      


Leu Leu Gln Val Ala Ser Ser Gly Leu Phe Arg Met Pro Cys Gly Glu 
            20                  25                  30          


Arg Lys Arg Val Glu Ala Arg Arg Ser Gly Gly Arg Ser Gly Val Glu 
        35                  40                  45              


Glu Met Arg Gly Ser Gly Ser Leu Trp Glu Val Asp Leu Arg Thr Asp 
    50                  55                  60                  


Trp Asn 
65      


<210>  7094
<211>  64
<212>  PRT
<213>  Homo Sapiens

<400>  7094

Met Gly Trp Leu Cys Ser Gly Leu Leu Phe Pro Val Ser Cys Leu Val 
1               5                   10                  15      


Leu Leu Gln Val Ala Ser Ser Gly Asn Met Lys Val Leu Gln Glu Pro 
            20                  25                  30          


Thr Cys Val Ser Asp Tyr Met Ser Ile Ser Thr Cys Glu Trp Lys Met 
        35                  40                  45              


Asn Gly Pro Thr Asn Cys Ser Thr Glu Leu Arg Leu Leu Tyr Gln Leu 
    50                  55                  60                  


<210>  7095
<211>  120
<212>  PRT
<213>  Homo Sapiens

<400>  7095

Met Gly Trp Leu Cys Ser Gly Leu Leu Phe Pro Val Ser Cys Leu Val 
1               5                   10                  15      


Leu Leu Gln Val Ala Ser Ser Gly Asn Met Lys Val Leu Gln Glu Pro 
            20                  25                  30          


Thr Cys Val Ser Asp Tyr Met Ser Ile Ser Thr Cys Glu Trp Lys Met 
        35                  40                  45              


Asn Gly Pro Thr Asn Cys Ser Thr Glu Leu Arg Leu Leu Tyr Gln Leu 
    50                  55                  60                  


Val Phe Leu Leu Ser Glu Ala His Thr Cys Ile Pro Glu Asn Asn Gly 
65                  70                  75                  80  


Gly Ala Gly Cys Val Cys His Leu Leu Met Asp Asp Val Val Ser Ala 
                85                  90                  95      


Asp Asn Tyr Thr Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu Trp Lys 
            100                 105                 110         


Gly Ser Phe Lys Pro Ser Glu His 
        115                 120 


<210>  7096
<211>  120
<212>  PRT
<213>  Homo Sapiens

<400>  7096

Met Gly Trp Leu Cys Ser Gly Leu Leu Phe Pro Val Ser Cys Leu Val 
1               5                   10                  15      


Leu Leu Gln Val Ala Ser Ser Gly Asn Met Lys Val Leu Gln Glu Pro 
            20                  25                  30          


Thr Cys Val Ser Asp Tyr Met Ser Ile Ser Thr Cys Glu Trp Lys Met 
        35                  40                  45              


Asn Gly Pro Thr Asn Cys Ser Thr Glu Leu Arg Leu Leu Tyr Gln Leu 
    50                  55                  60                  


Val Phe Leu Leu Ser Glu Ala His Thr Cys Ile Pro Glu Asn Asn Gly 
65                  70                  75                  80  


Gly Ala Gly Cys Val Cys His Leu Leu Met Asp Asp Val Val Ser Ala 
                85                  90                  95      


Asp Asn Tyr Thr Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu Trp Lys 
            100                 105                 110         


Gly Ser Phe Lys Pro Ser Glu His 
        115                 120 


<210>  7097
<211>  825
<212>  PRT
<213>  Homo Sapiens

<400>  7097

Met Gly Trp Leu Cys Ser Gly Leu Leu Phe Pro Val Ser Cys Leu Val 
1               5                   10                  15      


Leu Leu Gln Val Ala Ser Ser Gly Asn Met Lys Val Leu Gln Glu Pro 
            20                  25                  30          


Thr Cys Val Ser Asp Tyr Met Ser Ile Ser Thr Cys Glu Trp Lys Met 
        35                  40                  45              


Asn Gly Pro Thr Asn Cys Ser Thr Glu Leu Arg Leu Leu Tyr Gln Leu 
    50                  55                  60                  


Val Phe Leu Leu Ser Glu Ala His Thr Cys Ile Pro Glu Asn Asn Gly 
65                  70                  75                  80  


Gly Ala Gly Cys Val Cys His Leu Leu Met Asp Asp Val Val Ser Ala 
                85                  90                  95      


Asp Asn Tyr Thr Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu Trp Lys 
            100                 105                 110         


Gly Ser Phe Lys Pro Ser Glu His Val Lys Pro Arg Ala Pro Gly Asn 
        115                 120                 125             


Leu Thr Val His Thr Asn Val Ser Asp Thr Leu Leu Leu Thr Trp Ser 
    130                 135                 140                 


Asn Pro Tyr Pro Pro Asp Asn Tyr Leu Tyr Asn His Leu Thr Tyr Ala 
145                 150                 155                 160 


Val Asn Ile Trp Ser Glu Asn Asp Pro Ala Asp Phe Arg Ile Tyr Asn 
                165                 170                 175     


Val Thr Tyr Leu Glu Pro Ser Leu Arg Ile Ala Ala Ser Thr Leu Lys 
            180                 185                 190         


Ser Gly Ile Ser Tyr Arg Ala Arg Val Arg Ala Trp Ala Gln Cys Tyr 
        195                 200                 205             


Asn Thr Thr Trp Ser Glu Trp Ser Pro Ser Thr Lys Trp His Asn Ser 
    210                 215                 220                 


Tyr Arg Glu Pro Phe Glu Gln His Leu Leu Leu Gly Val Ser Val Ser 
225                 230                 235                 240 


Cys Ile Val Ile Leu Ala Val Cys Leu Leu Cys Tyr Val Ser Ile Thr 
                245                 250                 255     


Lys Ile Lys Lys Glu Trp Trp Asp Gln Ile Pro Asn Pro Ala Arg Ser 
            260                 265                 270         


Arg Leu Val Ala Ile Ile Ile Gln Asp Ala Gln Gly Ser Gln Trp Glu 
        275                 280                 285             


Lys Arg Ser Arg Gly Gln Glu Pro Ala Lys Cys Pro His Trp Lys Asn 
    290                 295                 300                 


Cys Leu Thr Lys Leu Leu Pro Cys Phe Leu Glu His Asn Met Lys Arg 
305                 310                 315                 320 


Asp Glu Asp Pro His Lys Ala Ala Lys Glu Met Pro Phe Gln Gly Ser 
                325                 330                 335     


Gly Lys Ser Ala Trp Cys Pro Val Glu Ile Ser Lys Thr Val Leu Trp 
            340                 345                 350         


Pro Glu Ser Ile Ser Val Val Arg Cys Val Glu Leu Phe Glu Ala Pro 
        355                 360                 365             


Val Glu Cys Glu Glu Glu Glu Glu Val Glu Glu Glu Lys Gly Ser Phe 
    370                 375                 380                 


Cys Ala Ser Pro Glu Ser Ser Arg Asp Asp Phe Gln Glu Gly Arg Glu 
385                 390                 395                 400 


Gly Ile Val Ala Arg Leu Thr Glu Ser Leu Phe Leu Asp Leu Leu Gly 
                405                 410                 415     


Glu Glu Asn Gly Gly Phe Cys Gln Gln Asp Met Gly Glu Ser Cys Leu 
            420                 425                 430         


Leu Pro Pro Ser Gly Ser Thr Ser Ala His Met Pro Trp Asp Glu Phe 
        435                 440                 445             


Pro Ser Ala Gly Pro Lys Glu Ala Pro Pro Trp Gly Lys Glu Gln Pro 
    450                 455                 460                 


Leu His Leu Glu Pro Ser Pro Pro Ala Ser Pro Thr Gln Ser Pro Asp 
465                 470                 475                 480 


Asn Leu Thr Cys Thr Glu Thr Pro Leu Val Ile Ala Gly Asn Pro Ala 
                485                 490                 495     


Tyr Arg Ser Phe Ser Asn Ser Leu Ser Gln Ser Pro Cys Pro Arg Glu 
            500                 505                 510         


Leu Gly Pro Asp Pro Leu Leu Ala Arg His Leu Glu Glu Val Glu Pro 
        515                 520                 525             


Glu Met Pro Cys Val Pro Gln Leu Ser Glu Pro Thr Thr Val Pro Gln 
    530                 535                 540                 


Pro Glu Pro Glu Thr Trp Glu Gln Ile Leu Arg Arg Asn Val Leu Gln 
545                 550                 555                 560 


His Gly Ala Ala Ala Ala Pro Val Ser Ala Pro Thr Ser Gly Tyr Gln 
                565                 570                 575     


Glu Phe Val His Ala Val Glu Gln Gly Gly Thr Gln Ala Ser Ala Val 
            580                 585                 590         


Val Gly Leu Gly Pro Pro Gly Glu Ala Gly Tyr Lys Ala Phe Ser Ser 
        595                 600                 605             


Leu Leu Ala Ser Ser Ala Val Ser Pro Glu Lys Cys Gly Phe Gly Ala 
    610                 615                 620                 


Ser Ser Gly Glu Glu Gly Tyr Lys Pro Phe Gln Asp Leu Ile Pro Gly 
625                 630                 635                 640 


Cys Pro Gly Asp Pro Ala Pro Val Pro Val Pro Leu Phe Thr Phe Gly 
                645                 650                 655     


Leu Asp Arg Glu Pro Pro Arg Ser Pro Gln Ser Ser His Leu Pro Ser 
            660                 665                 670         


Ser Ser Pro Glu His Leu Gly Leu Glu Pro Gly Glu Lys Val Glu Asp 
        675                 680                 685             


Met Pro Lys Pro Pro Leu Pro Gln Glu Gln Ala Thr Asp Pro Leu Val 
    690                 695                 700                 


Asp Ser Leu Gly Ser Gly Ile Val Tyr Ser Ala Leu Thr Cys His Leu 
705                 710                 715                 720 


Cys Gly His Leu Lys Gln Cys His Gly Gln Glu Asp Gly Gly Gln Thr 
                725                 730                 735     


Pro Val Met Ala Ser Pro Cys Cys Gly Cys Cys Cys Gly Asp Arg Ser 
            740                 745                 750         


Ser Pro Pro Thr Thr Pro Leu Arg Ala Pro Asp Pro Ser Pro Gly Gly 
        755                 760                 765             


Val Pro Leu Glu Ala Ser Leu Cys Pro Ala Ser Leu Ala Pro Ser Gly 
    770                 775                 780                 


Ile Ser Glu Lys Ser Lys Ser Ser Ser Ser Phe His Pro Ala Pro Gly 
785                 790                 795                 800 


Asn Ala Gln Ser Ser Ser Gln Thr Pro Lys Ile Val Asn Phe Val Ser 
                805                 810                 815     


Val Gly Pro Thr Tyr Met Arg Val Ser 
            820                 825 


<210>  7098
<211>  825
<212>  PRT
<213>  Homo Sapiens

<400>  7098

Met Gly Trp Leu Cys Ser Gly Leu Leu Phe Pro Val Ser Cys Leu Val 
1               5                   10                  15      


Leu Leu Gln Val Ala Ser Ser Gly Asn Met Lys Val Leu Gln Glu Pro 
            20                  25                  30          


Thr Cys Val Ser Asp Tyr Met Ser Ile Ser Thr Cys Glu Trp Lys Met 
        35                  40                  45              


Asn Gly Pro Thr Asn Cys Ser Thr Glu Leu Arg Leu Leu Tyr Gln Leu 
    50                  55                  60                  


Val Phe Leu Leu Ser Glu Ala His Thr Cys Ile Pro Glu Asn Asn Gly 
65                  70                  75                  80  


Gly Ala Gly Cys Val Cys His Leu Leu Met Asp Asp Val Val Ser Ala 
                85                  90                  95      


Asp Asn Tyr Thr Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu Trp Lys 
            100                 105                 110         


Gly Ser Phe Lys Pro Ser Glu His Val Lys Pro Arg Ala Pro Gly Asn 
        115                 120                 125             


Leu Thr Val His Thr Asn Val Ser Asp Thr Leu Leu Leu Thr Trp Ser 
    130                 135                 140                 


Asn Pro Tyr Pro Pro Asp Asn Tyr Leu Tyr Asn His Leu Thr Tyr Ala 
145                 150                 155                 160 


Val Asn Ile Trp Ser Glu Asn Asp Pro Ala Asp Phe Arg Ile Tyr Asn 
                165                 170                 175     


Val Thr Tyr Leu Glu Pro Ser Leu Arg Ile Ala Ala Ser Thr Leu Lys 
            180                 185                 190         


Ser Gly Ile Ser Tyr Arg Ala Arg Val Arg Ala Trp Ala Gln Cys Tyr 
        195                 200                 205             


Asn Thr Thr Trp Ser Glu Trp Ser Pro Ser Thr Lys Trp His Asn Ser 
    210                 215                 220                 


Tyr Arg Glu Pro Phe Glu Gln His Leu Leu Leu Gly Val Ser Val Ser 
225                 230                 235                 240 


Cys Ile Val Ile Leu Ala Val Cys Leu Leu Cys Tyr Val Ser Ile Thr 
                245                 250                 255     


Lys Ile Lys Lys Glu Trp Trp Asp Gln Ile Pro Asn Pro Ala Arg Ser 
            260                 265                 270         


Arg Leu Val Ala Ile Ile Ile Gln Asp Ala Gln Gly Ser Gln Trp Glu 
        275                 280                 285             


Lys Arg Ser Arg Gly Gln Glu Pro Ala Lys Cys Pro His Trp Lys Asn 
    290                 295                 300                 


Cys Leu Thr Lys Leu Leu Pro Cys Phe Leu Glu His Asn Met Lys Arg 
305                 310                 315                 320 


Asp Glu Asp Pro His Lys Ala Ala Lys Glu Met Pro Phe Gln Gly Ser 
                325                 330                 335     


Gly Lys Ser Ala Trp Cys Pro Val Glu Ile Ser Lys Thr Val Leu Trp 
            340                 345                 350         


Pro Glu Ser Ile Ser Val Val Arg Cys Val Glu Leu Phe Glu Ala Pro 
        355                 360                 365             


Val Glu Cys Glu Glu Glu Glu Glu Val Glu Glu Glu Lys Gly Ser Phe 
    370                 375                 380                 


Cys Ala Ser Pro Glu Ser Ser Arg Asp Asp Phe Gln Glu Gly Arg Glu 
385                 390                 395                 400 


Gly Ile Val Ala Arg Leu Thr Glu Ser Leu Phe Leu Asp Leu Leu Gly 
                405                 410                 415     


Glu Glu Asn Gly Gly Phe Cys Gln Gln Asp Met Gly Glu Ser Cys Leu 
            420                 425                 430         


Leu Pro Pro Ser Gly Ser Thr Ser Ala His Met Pro Trp Asp Glu Phe 
        435                 440                 445             


Pro Ser Ala Gly Pro Lys Glu Ala Pro Pro Trp Gly Lys Glu Gln Pro 
    450                 455                 460                 


Leu His Leu Glu Pro Ser Pro Pro Ala Ser Pro Thr Gln Ser Pro Asp 
465                 470                 475                 480 


Asn Leu Thr Cys Thr Glu Thr Pro Leu Val Ile Ala Gly Asn Pro Ala 
                485                 490                 495     


Tyr Arg Ser Phe Ser Asn Ser Leu Ser Gln Ser Pro Cys Pro Arg Glu 
            500                 505                 510         


Leu Gly Pro Asp Pro Leu Leu Ala Arg His Leu Glu Glu Val Glu Pro 
        515                 520                 525             


Glu Met Pro Cys Val Pro Gln Leu Ser Glu Pro Thr Thr Val Pro Gln 
    530                 535                 540                 


Pro Glu Pro Glu Thr Trp Glu Gln Ile Leu Arg Arg Asn Val Leu Gln 
545                 550                 555                 560 


His Gly Ala Ala Ala Ala Pro Val Ser Ala Pro Thr Ser Gly Tyr Gln 
                565                 570                 575     


Glu Phe Val His Ala Val Glu Gln Gly Gly Thr Gln Ala Ser Ala Val 
            580                 585                 590         


Val Gly Leu Gly Pro Pro Gly Glu Ala Gly Tyr Lys Ala Phe Ser Ser 
        595                 600                 605             


Leu Leu Ala Ser Ser Ala Val Ser Pro Glu Lys Cys Gly Phe Gly Ala 
    610                 615                 620                 


Ser Ser Gly Glu Glu Gly Tyr Lys Pro Phe Gln Asp Leu Ile Pro Gly 
625                 630                 635                 640 


Cys Pro Gly Asp Pro Ala Pro Val Pro Val Pro Leu Phe Thr Phe Gly 
                645                 650                 655     


Leu Asp Arg Glu Pro Pro Arg Ser Pro Gln Ser Ser His Leu Pro Ser 
            660                 665                 670         


Ser Ser Pro Glu His Leu Gly Leu Glu Pro Gly Glu Lys Val Glu Asp 
        675                 680                 685             


Met Pro Lys Pro Pro Leu Pro Gln Glu Gln Ala Thr Asp Pro Leu Val 
    690                 695                 700                 


Asp Ser Leu Gly Ser Gly Ile Val Tyr Ser Ala Leu Thr Cys His Leu 
705                 710                 715                 720 


Cys Gly His Leu Lys Gln Cys His Gly Gln Glu Asp Gly Gly Gln Thr 
                725                 730                 735     


Pro Val Met Ala Ser Pro Cys Cys Gly Cys Cys Cys Gly Asp Arg Ser 
            740                 745                 750         


Ser Pro Pro Thr Thr Pro Leu Arg Ala Pro Asp Pro Ser Pro Gly Gly 
        755                 760                 765             


Val Pro Leu Glu Ala Ser Leu Cys Pro Ala Ser Leu Ala Pro Ser Gly 
    770                 775                 780                 


Ile Ser Glu Lys Ser Lys Ser Ser Ser Ser Phe His Pro Ala Pro Gly 
785                 790                 795                 800 


Asn Ala Gln Ser Ser Ser Gln Thr Pro Lys Ile Val Asn Phe Val Ser 
                805                 810                 815     


Val Gly Pro Thr Tyr Met Arg Val Ser 
            820                 825 


<210>  7099
<211>  124
<212>  PRT
<213>  Homo Sapiens

<400>  7099

Met Gly Trp Leu Cys Ser Gly Leu Leu Phe Pro Val Ser Cys Leu Val 
1               5                   10                  15      


Leu Leu Gln Val Ala Ser Ser Gly Asn Met Lys Val Leu Gln Glu Pro 
            20                  25                  30          


Thr Cys Val Ser Asp Tyr Met Ser Ile Ser Thr Cys Glu Trp Lys Met 
        35                  40                  45              


Asn Gly Pro Thr Asn Cys Ser Thr Glu Leu Arg Leu Leu Tyr Gln Leu 
    50                  55                  60                  


Val Phe Leu Leu Ser Glu Ala His Thr Cys Ile Pro Glu Asn Asn Gly 
65                  70                  75                  80  


Gly Ala Gly Cys Val Cys His Leu Leu Met Asp Asp Val Val Ser Ala 
                85                  90                  95      


Asp Asn Tyr Thr Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu Trp Lys 
            100                 105                 110         


Gly Ser Phe Lys Pro Ser Glu His Val Gln Asn Leu 
        115                 120                 


<210>  7100
<211>  810
<212>  PRT
<213>  Homo Sapiens

<400>  7100

Met Gln Lys Asp Ala Arg Arg Glu Gly Asn Met Lys Val Leu Gln Glu 
1               5                   10                  15      


Pro Thr Cys Val Ser Asp Tyr Met Ser Ile Ser Thr Cys Glu Trp Lys 
            20                  25                  30          


Met Asn Gly Pro Thr Asn Cys Ser Thr Glu Leu Arg Leu Leu Tyr Gln 
        35                  40                  45              


Leu Val Phe Leu Leu Ser Glu Ala His Thr Cys Ile Pro Glu Asn Asn 
    50                  55                  60                  


Gly Gly Ala Gly Cys Val Cys His Leu Leu Met Asp Asp Val Val Ser 
65                  70                  75                  80  


Ala Asp Asn Tyr Thr Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu Trp 
                85                  90                  95      


Lys Gly Ser Phe Lys Pro Ser Glu His Val Lys Pro Arg Ala Pro Gly 
            100                 105                 110         


Asn Leu Thr Val His Thr Asn Val Ser Asp Thr Leu Leu Leu Thr Trp 
        115                 120                 125             


Ser Asn Pro Tyr Pro Pro Asp Asn Tyr Leu Tyr Asn His Leu Thr Tyr 
    130                 135                 140                 


Ala Val Asn Ile Trp Ser Glu Asn Asp Pro Ala Asp Phe Arg Ile Tyr 
145                 150                 155                 160 


Asn Val Thr Tyr Leu Glu Pro Ser Leu Arg Ile Ala Ala Ser Thr Leu 
                165                 170                 175     


Lys Ser Gly Ile Ser Tyr Arg Ala Arg Val Arg Ala Trp Ala Gln Cys 
            180                 185                 190         


Tyr Asn Thr Thr Trp Ser Glu Trp Ser Pro Ser Thr Lys Trp His Asn 
        195                 200                 205             


Ser Tyr Arg Glu Pro Phe Glu Gln His Leu Leu Leu Gly Val Ser Val 
    210                 215                 220                 


Ser Cys Ile Val Ile Leu Ala Val Cys Leu Leu Cys Tyr Val Ser Ile 
225                 230                 235                 240 


Thr Lys Ile Lys Lys Glu Trp Trp Asp Gln Ile Pro Asn Pro Ala Arg 
                245                 250                 255     


Ser Arg Leu Val Ala Ile Ile Ile Gln Asp Ala Gln Gly Ser Gln Trp 
            260                 265                 270         


Glu Lys Arg Ser Arg Gly Gln Glu Pro Ala Lys Cys Pro His Trp Lys 
        275                 280                 285             


Asn Cys Leu Thr Lys Leu Leu Pro Cys Phe Leu Glu His Asn Met Lys 
    290                 295                 300                 


Arg Asp Glu Asp Pro His Lys Ala Ala Lys Glu Met Pro Phe Gln Gly 
305                 310                 315                 320 


Ser Gly Lys Ser Ala Trp Cys Pro Val Glu Ile Ser Lys Thr Val Leu 
                325                 330                 335     


Trp Pro Glu Ser Ile Ser Val Val Arg Cys Val Glu Leu Phe Glu Ala 
            340                 345                 350         


Pro Val Glu Cys Glu Glu Glu Glu Glu Val Glu Glu Glu Lys Gly Ser 
        355                 360                 365             


Phe Cys Ala Ser Pro Glu Ser Ser Arg Asp Asp Phe Gln Glu Gly Arg 
    370                 375                 380                 


Glu Gly Ile Val Ala Arg Leu Thr Glu Ser Leu Phe Leu Asp Leu Leu 
385                 390                 395                 400 


Gly Glu Glu Asn Gly Gly Phe Cys Gln Gln Asp Met Gly Glu Ser Cys 
                405                 410                 415     


Leu Leu Pro Pro Ser Gly Ser Thr Ser Ala His Met Pro Trp Asp Glu 
            420                 425                 430         


Phe Pro Ser Ala Gly Pro Lys Glu Ala Pro Pro Trp Gly Lys Glu Gln 
        435                 440                 445             


Pro Leu His Leu Glu Pro Ser Pro Pro Ala Ser Pro Thr Gln Ser Pro 
    450                 455                 460                 


Asp Asn Leu Thr Cys Thr Glu Thr Pro Leu Val Ile Ala Gly Asn Pro 
465                 470                 475                 480 


Ala Tyr Arg Ser Phe Ser Asn Ser Leu Ser Gln Ser Pro Cys Pro Arg 
                485                 490                 495     


Glu Leu Gly Pro Asp Pro Leu Leu Ala Arg His Leu Glu Glu Val Glu 
            500                 505                 510         


Pro Glu Met Pro Cys Val Pro Gln Leu Ser Glu Pro Thr Thr Val Pro 
        515                 520                 525             


Gln Pro Glu Pro Glu Thr Trp Glu Gln Ile Leu Arg Arg Asn Val Leu 
    530                 535                 540                 


Gln His Gly Ala Ala Ala Ala Pro Val Ser Ala Pro Thr Ser Gly Tyr 
545                 550                 555                 560 


Gln Glu Phe Val His Ala Val Glu Gln Gly Gly Thr Gln Ala Ser Ala 
                565                 570                 575     


Val Val Gly Leu Gly Pro Pro Gly Glu Ala Gly Tyr Lys Ala Phe Ser 
            580                 585                 590         


Ser Leu Leu Ala Ser Ser Ala Val Ser Pro Glu Lys Cys Gly Phe Gly 
        595                 600                 605             


Ala Ser Ser Gly Glu Glu Gly Tyr Lys Pro Phe Gln Asp Leu Ile Pro 
    610                 615                 620                 


Gly Cys Pro Gly Asp Pro Ala Pro Val Pro Val Pro Leu Phe Thr Phe 
625                 630                 635                 640 


Gly Leu Asp Arg Glu Pro Pro Arg Ser Pro Gln Ser Ser His Leu Pro 
                645                 650                 655     


Ser Ser Ser Pro Glu His Leu Gly Leu Glu Pro Gly Glu Lys Val Glu 
            660                 665                 670         


Asp Met Pro Lys Pro Pro Leu Pro Gln Glu Gln Ala Thr Asp Pro Leu 
        675                 680                 685             


Val Asp Ser Leu Gly Ser Gly Ile Val Tyr Ser Ala Leu Thr Cys His 
    690                 695                 700                 


Leu Cys Gly His Leu Lys Gln Cys His Gly Gln Glu Asp Gly Gly Gln 
705                 710                 715                 720 


Thr Pro Val Met Ala Ser Pro Cys Cys Gly Cys Cys Cys Gly Asp Arg 
                725                 730                 735     


Ser Ser Pro Pro Thr Thr Pro Leu Arg Ala Pro Asp Pro Ser Pro Gly 
            740                 745                 750         


Gly Val Pro Leu Glu Ala Ser Leu Cys Pro Ala Ser Leu Ala Pro Ser 
        755                 760                 765             


Gly Ile Ser Glu Lys Ser Lys Ser Ser Ser Ser Phe His Pro Ala Pro 
    770                 775                 780                 


Gly Asn Ala Gln Ser Ser Ser Gln Thr Pro Lys Ile Val Asn Phe Val 
785                 790                 795                 800 


Ser Val Gly Pro Thr Tyr Met Arg Val Ser 
                805                 810 


<210>  7101
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  7101

Pro Ser Thr Lys Trp His Asn Ser Tyr Arg Glu Pro Phe Glu Gln His 
1               5                   10                  15      


Leu Leu Leu Gly Val Ser Val Ser Cys Ile Val Ile Leu Ala Val Cys 
            20                  25                  30          


Leu Leu Cys Tyr Val Ser Ile Thr Lys Ile Lys Lys Glu Trp Trp Asp 
        35                  40                  45              


Gln Ile Pro Asn Pro Ala Arg Ser Arg Leu Val Ala Ile Ile Ile Gln 
    50                  55                  60                  


Asp Ala Gln Gly Ser Gln Trp Glu Lys Arg Ser Arg Gly Pro Trp Ala 
65                  70                  75                  80  


Pro Arg Leu Val Asn Glu Leu Leu Ala Ala Pro Ser Thr Ala Ser Ala 
                85                  90                  95      


Ala Asp Cys Pro Cys Cys Asn Cys Pro Arg His Val Leu Pro Thr Arg 
            100                 105                 110         


Ser Trp Pro Thr Trp Arg Pro Thr Cys Leu Cys Leu Thr Glu Leu Glu 
        115                 120                 125             


Ala Glu Pro Arg Asn 
    130             


<210>  7102
<211>  49
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7102

Xaa Cys Val Cys His Leu Leu Met Asp Asp Val Val Ser Ala Asp Asn 
1               5                   10                  15      


Tyr Thr Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu Trp Lys Gly Ser 
            20                  25                  30          


Phe Lys Pro Ser Glu His Val Leu Pro Pro Leu Lys Arg Ser Trp Ser 
        35                  40                  45              


Gln 
    


<210>  7103
<211>  193
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7103

Xaa Asn Val Thr Tyr Leu Glu Pro Ser Leu Arg Ile Ala Ala Ser Thr 
1               5                   10                  15      


Leu Lys Ser Gly Ile Ser Tyr Arg Ala Arg Val Arg Ala Trp Ala Gln 
            20                  25                  30          


Cys Tyr Asn Thr Thr Trp Ser Glu Trp Ser Pro Ser Thr Lys Trp His 
        35                  40                  45              


Asn Ser Tyr Arg Glu Pro Phe Glu Gln His Leu Leu Leu Gly Val Ser 
    50                  55                  60                  


Val Ser Cys Ile Val Ile Leu Ala Val Cys Leu Leu Cys Tyr Val Ser 
65                  70                  75                  80  


Ile Thr Lys Ile Lys Lys Glu Trp Trp Asp Gln Ile Pro Asn Pro Ala 
                85                  90                  95      


Arg Ser Arg Leu Val Ala Ile Ile Ile Gln Asp Ala Gln Gly Ser Gln 
            100                 105                 110         


Trp Glu Lys Arg Ser Arg Gly Gln Glu Pro Ala Lys Cys Pro Leu Gln 
        115                 120                 125             


Gly Thr Ala Gly Gly Gly Val Phe Trp Lys Arg Gly Leu Leu Ala Lys 
    130                 135                 140                 


Pro Pro Glu Phe His Trp Cys Val Arg His Trp Lys Asn Cys Leu Thr 
145                 150                 155                 160 


Lys Leu Leu Pro Cys Phe Leu Glu His Asn Met Lys Arg Asp Glu Asp 
                165                 170                 175     


Pro His Lys Ala Ala Lys Glu Met Pro Phe Gln Gly Ser Gly Lys Ser 
            180                 185                 190         


Ala 
    


<210>  7104
<211>  51
<212>  PRT
<213>  Homo Sapiens

<400>  7104

Met Gly Val Val Val Gly Trp Ile Gly Asp Pro Gly Ser Gly Thr Leu 
1               5                   10                  15      


Arg Ile Pro Val Pro Val His Lys Asn His Gln Leu Cys Thr Glu Glu 
            20                  25                  30          


Ile Phe Gln Gly Ile Gly Thr Leu Glu Ser Gln Thr Val Gln Gly Gly 
        35                  40                  45              


Thr Val Glu 
    50      


<210>  7105
<211>  134
<212>  PRT
<213>  Homo Sapiens

<400>  7105

Met Arg Met Leu Leu His Leu Ser Leu Leu Ala Leu Gly Ala Ala Tyr 
1               5                   10                  15      


Val Tyr Ala Ile Pro Thr Glu Ile Pro Thr Ser Ala Leu Val Lys Glu 
            20                  25                  30          


Thr Leu Ala Leu Leu Ser Thr His Arg Thr Leu Leu Ile Ala Asn Glu 
        35                  40                  45              


Thr Leu Arg Ile Pro Val Pro Val His Lys Asn His Gln Leu Cys Thr 
    50                  55                  60                  


Glu Glu Ile Phe Gln Gly Ile Gly Thr Leu Glu Ser Gln Thr Val Gln 
65                  70                  75                  80  


Gly Gly Thr Val Glu Arg Leu Phe Lys Asn Leu Ser Leu Ile Lys Lys 
                85                  90                  95      


Tyr Ile Asp Gly Gln Lys Lys Lys Cys Gly Glu Glu Arg Arg Arg Val 
            100                 105                 110         


Asn Gln Phe Leu Asp Tyr Leu Gln Glu Phe Leu Gly Val Met Asn Thr 
        115                 120                 125             


Glu Trp Ile Ile Glu Ser 
    130                 


<210>  7106
<211>  109
<212>  PRT
<213>  Homo Sapiens

<400>  7106

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu 
            100                 105                 


<210>  7107
<211>  196
<212>  PRT
<213>  Homo Sapiens

<400>  7107

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser 
        115                 120                 125             


Ile Val Asn Leu Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser 
    130                 135                 140                 


Arg Leu Arg Ser Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly 
145                 150                 155                 160 


Thr Asp Ala Pro Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly 
                165                 170                 175     


Ser Trp Thr Glu Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg 
            180                 185                 190         


Asn Ile Ala Cys 
        195     


<210>  7108
<211>  420
<212>  PRT
<213>  Homo Sapiens

<400>  7108

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser 
        115                 120                 125             


Ile Val Asn Leu Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser 
    130                 135                 140                 


Arg Leu Arg Ser Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly 
145                 150                 155                 160 


Thr Asp Ala Pro Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly 
                165                 170                 175     


Ser Trp Thr Glu Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg 
            180                 185                 190         


Asn Ile Ala Cys Trp Phe Pro Arg Thr Phe Ile Leu Ser Lys Gly Arg 
        195                 200                 205             


Asp Trp Leu Ala Val Leu Val Asn Gly Ser Ser Lys His Ser Ala Ile 
    210                 215                 220                 


Arg Pro Phe Asp Gln Leu Phe Ala Leu His Ala Ile Asp Gln Ile Asn 
225                 230                 235                 240 


Pro Pro Leu Asn Val Thr Ala Glu Ile Glu Gly Thr Arg Leu Ser Ile 
                245                 250                 255     


Gln Trp Glu Lys Pro Val Ser Ala Phe Pro Ile His Cys Phe Asp Tyr 
            260                 265                 270         


Glu Val Lys Ile His Asn Thr Arg Asn Gly Tyr Leu Gln Ile Glu Lys 
        275                 280                 285             


Leu Met Thr Asn Ala Phe Ile Ser Ile Ile Asp Asp Leu Ser Lys Tyr 
    290                 295                 300                 


Asp Val Gln Val Arg Ala Ala Val Ser Ser Met Cys Arg Glu Ala Gly 
305                 310                 315                 320 


Leu Trp Ser Glu Trp Ser Gln Pro Ile Tyr Val Gly Asn Asp Glu His 
                325                 330                 335     


Lys Pro Leu Arg Glu Trp Phe Val Ile Val Ile Met Ala Thr Ile Cys 
            340                 345                 350         


Phe Ile Leu Leu Ile Leu Ser Leu Ile Cys Lys Ile Cys His Leu Trp 
        355                 360                 365             


Ile Lys Leu Phe Pro Pro Ile Pro Ala Pro Lys Ser Asn Ile Lys Asp 
    370                 375                 380                 


Leu Phe Val Thr Thr Asn Tyr Glu Lys Ala Gly Ser Ser Glu Thr Glu 
385                 390                 395                 400 


Ile Glu Val Ile Cys Tyr Ile Glu Lys Pro Gly Val Glu Thr Leu Glu 
                405                 410                 415     


Asp Ser Val Phe 
            420 


<210>  7109
<211>  335
<212>  PRT
<213>  Homo Sapiens

<400>  7109

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser 
        115                 120                 125             


Ile Val Asn Leu Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser 
    130                 135                 140                 


Arg Leu Arg Ser Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly 
145                 150                 155                 160 


Thr Asp Ala Pro Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly 
                165                 170                 175     


Ser Trp Thr Glu Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg 
            180                 185                 190         


Asn Ile Ala Cys Trp Phe Pro Arg Thr Phe Ile Leu Ser Lys Gly Arg 
        195                 200                 205             


Asp Trp Leu Ala Val Leu Val Asn Gly Ser Ser Lys His Ser Ala Ile 
    210                 215                 220                 


Arg Pro Phe Asp Gln Leu Phe Ala Leu His Ala Ile Asp Gln Ile Asn 
225                 230                 235                 240 


Pro Pro Leu Asn Val Thr Ala Glu Ile Glu Gly Thr Arg Leu Ser Ile 
                245                 250                 255     


Gln Trp Glu Lys Pro Val Ser Ala Phe Pro Ile His Cys Phe Asp Tyr 
            260                 265                 270         


Glu Val Lys Ile His Asn Thr Arg Asn Gly Tyr Leu Gln Ile Glu Lys 
        275                 280                 285             


Leu Met Thr Asn Ala Phe Ile Ser Ile Ile Asp Asp Leu Ser Lys Tyr 
    290                 295                 300                 


Asp Val Gln Val Arg Ala Ala Val Ser Ser Met Cys Arg Glu Ala Gly 
305                 310                 315                 320 


Leu Trp Ser Glu Trp Ser Gln Pro Ile Tyr Val Gly Phe Ser Arg 
                325                 330                 335 


<210>  7110
<211>  335
<212>  PRT
<213>  Homo Sapiens

<400>  7110

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser 
        115                 120                 125             


Ile Val Asn Leu Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser 
    130                 135                 140                 


Arg Leu Arg Ser Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly 
145                 150                 155                 160 


Thr Asp Ala Pro Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly 
                165                 170                 175     


Ser Trp Thr Glu Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg 
            180                 185                 190         


Asn Ile Ala Cys Trp Phe Pro Arg Thr Phe Ile Leu Ser Lys Gly Arg 
        195                 200                 205             


Asp Trp Leu Ala Val Leu Val Asn Gly Ser Ser Lys His Ser Ala Ile 
    210                 215                 220                 


Arg Pro Phe Asp Gln Leu Phe Ala Leu His Ala Ile Asp Gln Ile Asn 
225                 230                 235                 240 


Pro Pro Leu Asn Val Thr Ala Glu Ile Glu Gly Thr Arg Leu Ser Ile 
                245                 250                 255     


Gln Trp Glu Lys Pro Val Ser Ala Phe Pro Ile His Cys Phe Asp Tyr 
            260                 265                 270         


Glu Val Lys Ile His Asn Thr Arg Asn Gly Tyr Leu Gln Ile Glu Lys 
        275                 280                 285             


Leu Met Thr Asn Ala Phe Ile Ser Ile Ile Asp Asp Leu Ser Lys Tyr 
    290                 295                 300                 


Asp Val Gln Val Arg Ala Ala Val Ser Ser Met Cys Arg Glu Ala Gly 
305                 310                 315                 320 


Leu Trp Ser Glu Trp Ser Gln Pro Ile Tyr Val Gly Phe Ser Arg 
                325                 330                 335 


<210>  7111
<211>  333
<212>  PRT
<213>  Homo Sapiens

<400>  7111

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser 
        115                 120                 125             


Ile Val Asn Leu Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser 
    130                 135                 140                 


Arg Leu Arg Ser Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly 
145                 150                 155                 160 


Thr Asp Ala Pro Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly 
                165                 170                 175     


Ser Trp Thr Glu Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg 
            180                 185                 190         


Asn Ile Ala Cys Trp Phe Pro Arg Thr Phe Ile Leu Ser Lys Gly Arg 
        195                 200                 205             


Asp Trp Leu Ala Val Leu Val Asn Gly Ser Ser Lys His Ser Ala Ile 
    210                 215                 220                 


Arg Pro Phe Asp Gln Leu Phe Ala Leu His Ala Ile Asp Gln Ile Asn 
225                 230                 235                 240 


Pro Pro Leu Asn Val Thr Ala Glu Ile Glu Gly Thr Arg Leu Ser Ile 
                245                 250                 255     


Gln Trp Glu Lys Pro Val Ser Ala Phe Pro Ile His Cys Phe Asp Tyr 
            260                 265                 270         


Glu Val Lys Ile His Asn Thr Arg Asn Gly Tyr Leu Gln Ile Glu Lys 
        275                 280                 285             


Leu Met Thr Asn Ala Phe Ile Ser Ile Ile Asp Asp Leu Ser Lys Tyr 
    290                 295                 300                 


Asp Val Gln Val Arg Ala Ala Val Ser Ser Met Cys Arg Glu Ala Gly 
305                 310                 315                 320 


Leu Trp Ser Glu Trp Ser Gln Pro Ile Tyr Val Gly Lys 
                325                 330             


<210>  7112
<211>  420
<212>  PRT
<213>  Homo Sapiens

<400>  7112

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser 
        115                 120                 125             


Ile Val Asn Leu Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser 
    130                 135                 140                 


Arg Leu Arg Ser Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly 
145                 150                 155                 160 


Thr Asp Ala Pro Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly 
                165                 170                 175     


Ser Trp Thr Glu Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg 
            180                 185                 190         


Asn Ile Ala Cys Trp Phe Pro Arg Thr Phe Ile Leu Ser Lys Gly Arg 
        195                 200                 205             


Asp Trp Leu Ala Val Leu Val Asn Gly Ser Ser Lys His Ser Ala Ile 
    210                 215                 220                 


Arg Pro Phe Asp Gln Leu Phe Ala Leu His Ala Ile Asp Gln Ile Asn 
225                 230                 235                 240 


Pro Pro Leu Asn Val Thr Ala Glu Ile Glu Gly Thr Arg Leu Ser Ile 
                245                 250                 255     


Gln Trp Glu Lys Pro Val Ser Ala Phe Pro Ile His Cys Phe Asp Tyr 
            260                 265                 270         


Glu Val Lys Ile His Asn Thr Arg Asn Gly Tyr Leu Gln Ile Glu Lys 
        275                 280                 285             


Leu Met Thr Asn Ala Phe Ile Ser Ile Ile Asp Asp Leu Ser Lys Tyr 
    290                 295                 300                 


Asp Val Gln Val Arg Ala Ala Val Ser Ser Met Cys Arg Glu Ala Gly 
305                 310                 315                 320 


Leu Trp Ser Glu Trp Ser Gln Pro Ile Tyr Val Gly Asn Asp Glu His 
                325                 330                 335     


Lys Pro Leu Arg Glu Trp Phe Val Ile Val Ile Met Ala Thr Ile Cys 
            340                 345                 350         


Phe Ile Leu Leu Ile Leu Ser Leu Ile Cys Lys Ile Cys His Leu Trp 
        355                 360                 365             


Ile Lys Leu Phe Pro Pro Ile Pro Ala Pro Lys Ser Asn Ile Lys Asp 
    370                 375                 380                 


Leu Phe Val Thr Thr Asn Tyr Glu Lys Ala Gly Ser Ser Glu Thr Glu 
385                 390                 395                 400 


Ile Glu Val Ile Cys Tyr Ile Glu Lys Pro Gly Val Glu Thr Leu Glu 
                405                 410                 415     


Asp Ser Val Phe 
            420 


<210>  7113
<211>  378
<212>  PRT
<213>  Homo Sapiens

<400>  7113

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser 
        115                 120                 125             


Ile Val Asn Leu Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser 
    130                 135                 140                 


Arg Leu Arg Ser Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly 
145                 150                 155                 160 


Thr Asp Ala Pro Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly 
                165                 170                 175     


Ser Trp Thr Glu Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg 
            180                 185                 190         


Asn Ile Ala Cys Trp Phe Pro Arg Thr Phe Ile Leu Ser Lys Gly Arg 
        195                 200                 205             


Asp Trp Leu Ala Val Leu Val Asn Gly Ser Ser Lys His Ser Ala Ile 
    210                 215                 220                 


Arg Pro Phe Asp Gln Leu Phe Ala Leu His Ala Ile Asp Gln Ile Asn 
225                 230                 235                 240 


Pro Pro Leu Asn Val Thr Ala Glu Ile Glu Gly Thr Arg Leu Ser Ile 
                245                 250                 255     


Gln Trp Glu Lys Pro Val Ser Ala Phe Pro Ile His Cys Phe Asp Tyr 
            260                 265                 270         


Glu Val Lys Ile His Asn Thr Arg Asn Gly Tyr Leu Gln Ile Glu Lys 
        275                 280                 285             


Leu Met Thr Asn Ala Phe Ile Ser Ile Ile Asp Asp Leu Ser Lys Tyr 
    290                 295                 300                 


Asp Val Gln Val Arg Ala Ala Val Ser Ser Met Cys Arg Glu Ala Gly 
305                 310                 315                 320 


Leu Trp Ser Glu Trp Ser Gln Pro Ile Tyr Val Gly Asn Asp Glu His 
                325                 330                 335     


Lys Pro Leu Arg Glu Trp Phe Val Ile Val Ile Met Ala Thr Ile Cys 
            340                 345                 350         


Phe Ile Leu Leu Ile Leu Ser Leu Ile Cys Lys Ile Lys Leu Gly Pro 
        355                 360                 365             


Val Arg Arg Lys Leu Lys Ser Ser Val Ile 
    370                 375             


<210>  7114
<211>  333
<212>  PRT
<213>  Homo Sapiens

<400>  7114

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser 
        115                 120                 125             


Ile Val Asn Leu Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser 
    130                 135                 140                 


Arg Leu Arg Ser Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly 
145                 150                 155                 160 


Thr Asp Ala Pro Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly 
                165                 170                 175     


Ser Trp Thr Glu Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg 
            180                 185                 190         


Asn Ile Ala Cys Trp Phe Pro Arg Thr Phe Ile Leu Ser Lys Gly Arg 
        195                 200                 205             


Asp Trp Leu Ala Val Leu Val Asn Gly Ser Ser Lys His Ser Ala Ile 
    210                 215                 220                 


Arg Pro Phe Asp Gln Leu Phe Ala Leu His Ala Ile Asp Gln Ile Asn 
225                 230                 235                 240 


Pro Pro Leu Asn Val Thr Ala Glu Ile Glu Gly Thr Arg Leu Ser Ile 
                245                 250                 255     


Gln Trp Glu Lys Pro Val Ser Ala Phe Pro Ile His Cys Phe Asp Tyr 
            260                 265                 270         


Glu Val Lys Ile His Asn Thr Arg Asn Gly Tyr Leu Gln Ile Glu Lys 
        275                 280                 285             


Leu Met Thr Asn Ala Phe Ile Ser Ile Ile Asp Asp Leu Ser Lys Tyr 
    290                 295                 300                 


Asp Val Gln Val Arg Ala Ala Val Ser Ser Met Cys Arg Glu Ala Gly 
305                 310                 315                 320 


Leu Trp Ser Glu Trp Ser Gln Pro Ile Tyr Val Gly Lys 
                325                 330             


<210>  7115
<211>  325
<212>  PRT
<213>  Homo Sapiens

<400>  7115

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser 
        115                 120                 125             


Ile Val Asn Leu Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser 
    130                 135                 140                 


Arg Leu Arg Ser Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly 
145                 150                 155                 160 


Thr Asp Ala Pro Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly 
                165                 170                 175     


Ser Trp Thr Glu Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg 
            180                 185                 190         


Asn Ile Ala Cys Trp Phe Pro Arg Thr Phe Ile Leu Ser Lys Gly Arg 
        195                 200                 205             


Asp Trp Leu Ala Val Leu Val Asn Gly Ser Ser Lys His Ser Ala Ile 
    210                 215                 220                 


Arg Pro Phe Asp Gln Leu Phe Ala Leu His Ala Ile Gly Asn Asp Glu 
225                 230                 235                 240 


His Lys Pro Leu Arg Glu Trp Phe Val Ile Val Ile Met Ala Thr Ile 
                245                 250                 255     


Cys Phe Ile Leu Leu Ile Leu Ser Leu Ile Cys Lys Ile Cys His Leu 
            260                 265                 270         


Trp Ile Lys Leu Phe Pro Pro Ile Pro Ala Pro Lys Ser Asn Ile Lys 
        275                 280                 285             


Asp Leu Phe Val Thr Thr Asn Tyr Glu Lys Ala Gly Ser Ser Glu Thr 
    290                 295                 300                 


Glu Ile Glu Val Ile Cys Tyr Ile Glu Lys Pro Gly Val Glu Thr Leu 
305                 310                 315                 320 


Glu Asp Ser Val Phe 
                325 


<210>  7116
<211>  136
<212>  PRT
<213>  Homo Sapiens

<400>  7116

Met Cys Glu Ser Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu 
1               5                   10                  15      


Pro Lys Met Ala Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu 
            20                  25                  30          


Glu Thr Cys Leu Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val 
        35                  40                  45              


Tyr Leu Glu Tyr Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala 
    50                  55                  60                  


Arg Ala Val Gln Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys 
65                  70                  75                  80  


Lys Ala Lys Asn Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn 
                85                  90                  95      


Ala Ser Leu Leu Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp 
            100                 105                 110         


Met Thr Thr His Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser 
        115                 120                 125             


Ser Leu Arg Ala Leu Arg Gln Met 
    130                 135     


<210>  7117
<211>  122
<212>  PRT
<213>  Homo Sapiens

<400>  7117

Met Cys Glu Ser Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu 
1               5                   10                  15      


Pro Lys Met Ala Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu 
            20                  25                  30          


Glu Thr Cys Leu Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val 
        35                  40                  45              


Tyr Leu Glu Tyr Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala 
    50                  55                  60                  


Arg Ala Val Gln Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys 
65                  70                  75                  80  


Lys Val Gly Val Ser Ser Phe Pro Gln Leu Gly Val Gly Glu Asp Arg 
                85                  90                  95      


Leu Lys Asp Ser Val Leu Asp Asn Ser Gly Met Gln Cys His Phe Gln 
            100                 105                 110         


Lys Arg Arg Leu His Val Asn Lys Arg Val 
        115                 120         


<210>  7118
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  7118

Met Asn Ser Phe Ser Thr Ile Pro Pro Gly Glu Asp Ser Lys Asp Val 
1               5                   10                  15      


Ala Ala Pro His Arg Gln Pro Leu Thr Ser Ser Glu Arg Ile Asp Lys 
            20                  25                  30          


Gln Ile Arg Tyr Ile Leu Asp Gly Ile Ser Ala Leu Arg Lys Glu Thr 
        35                  40                  45              


Cys Asn Lys Ser Asn Met Cys Glu Ser Ser Lys Glu Ala Leu Ala Glu 
    50                  55                  60                  


Asn Asn Leu Asn Leu Pro Lys Met Ala Glu Lys Asp Gly Cys Phe Gln 
65                  70                  75                  80  


Ser Gly Phe Asn Glu Glu Thr Cys Leu Val Lys Ile Ile Thr Gly Leu 
                85                  90                  95      


Leu Glu Phe Glu Val Tyr Leu Glu Tyr Leu Gln Asn Arg Phe Glu Ser 
            100                 105                 110         


Ser Glu Glu Gln Ala Arg Ala Val Gln Met Ser Thr Lys Val Leu Ile 
        115                 120                 125             


Gln Phe Leu Gln Lys Lys Ala Lys Asn Leu Asp Ala Ile Thr Thr Pro 
    130                 135                 140                 


Asp Pro Thr Thr Asn Ala Ser Leu Leu Thr Lys Leu Gln Ala Gln Asn 
145                 150                 155                 160 


Gln Trp Leu Gln Asp Met Thr Thr His Leu Ile Leu Arg Ser Phe Lys 
                165                 170                 175     


Glu Phe Leu Gln Ser Ser Leu Arg Ala Leu Arg Gln Met 
            180                 185                 


<210>  7119
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  7119

Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln 
145                 150         


<210>  7120
<211>  212
<212>  PRT
<213>  Homo Sapiens

<400>  7120

Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 
145                 150                 155                 160 


Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu 
                165                 170                 175     


Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 
            180                 185                 190         


Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala 
        195                 200                 205             


Leu Arg Gln Met 
    210         


<210>  7121
<211>  212
<212>  PRT
<213>  Homo Sapiens

<400>  7121

Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 
145                 150                 155                 160 


Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu 
                165                 170                 175     


Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 
            180                 185                 190         


Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala 
        195                 200                 205             


Leu Arg Gln Met 
    210         


<210>  7122
<211>  198
<212>  PRT
<213>  Homo Sapiens

<400>  7122

Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Val Gly Val 
145                 150                 155                 160 


Ser Ser Phe Pro Gln Leu Gly Val Gly Glu Asp Arg Leu Lys Asp Ser 
                165                 170                 175     


Val Leu Asp Asn Ser Gly Met Gln Cys His Phe Gln Lys Arg Arg Leu 
            180                 185                 190         


His Val Asn Lys Arg Val 
        195             


<210>  7123
<211>  171
<212>  PRT
<213>  Homo Sapiens

<400>  7123

Met Leu Ala Val Gly Cys Ala Leu Leu Ala Ala Leu Leu Ala Ala Pro 
1               5                   10                  15      


Gly Ala Ala Leu Ala Pro Arg Arg Cys Pro Ala Gln Glu Val Ala Arg 
            20                  25                  30          


Gly Val Leu Thr Ser Leu Pro Gly Asp Ser Val Thr Leu Thr Cys Pro 
        35                  40                  45              


Gly Val Glu Pro Glu Asp Asn Ala Thr Val His Trp Val Leu Arg Lys 
    50                  55                  60                  


Pro Ala Ala Gly Ser His Pro Ser Arg Trp Ala Gly Met Gly Arg Arg 
65                  70                  75                  80  


Leu Leu Leu Arg Ser Val Gln Leu His Asp Ser Gly Asn Tyr Ser Cys 
                85                  90                  95      


Tyr Arg Ala Gly Arg Pro Ala Gly Thr Val His Leu Leu Val Asp Val 
            100                 105                 110         


Pro Pro Glu Glu Pro Gln Leu Ser Cys Phe Arg Lys Ser Pro Leu Ser 
        115                 120                 125             


Asn Val Val Cys Glu Trp Gly Pro Arg Ser Thr Pro Ser Leu Thr Thr 
    130                 135                 140                 


Lys Ala Val Leu Leu Ser Glu Gln Ser Gly Arg Arg Leu Pro Gly Ala 
145                 150                 155                 160 


Val Pro Val Phe Pro Gly Val Pro Glu Val Leu 
                165                 170     


<210>  7124
<211>  365
<212>  PRT
<213>  Homo Sapiens

<400>  7124

Met Leu Ala Val Gly Cys Ala Leu Leu Ala Ala Leu Leu Ala Ala Pro 
1               5                   10                  15      


Gly Ala Ala Leu Ala Pro Arg Arg Cys Pro Ala Gln Glu Val Ala Arg 
            20                  25                  30          


Gly Val Leu Thr Ser Leu Pro Gly Asp Ser Val Thr Leu Thr Cys Pro 
        35                  40                  45              


Gly Val Glu Pro Glu Asp Asn Ala Thr Val His Trp Val Leu Arg Lys 
    50                  55                  60                  


Pro Ala Ala Gly Ser His Pro Ser Arg Trp Ala Gly Met Gly Arg Arg 
65                  70                  75                  80  


Leu Leu Leu Arg Ser Val Gln Leu His Asp Ser Gly Asn Tyr Ser Cys 
                85                  90                  95      


Tyr Arg Ala Gly Arg Pro Ala Gly Thr Val His Leu Leu Val Asp Val 
            100                 105                 110         


Pro Pro Glu Glu Pro Gln Leu Ser Cys Phe Arg Lys Ser Pro Leu Ser 
        115                 120                 125             


Asn Val Val Cys Glu Trp Gly Pro Arg Ser Thr Pro Ser Leu Thr Thr 
    130                 135                 140                 


Lys Ala Val Leu Leu Val Arg Lys Phe Gln Asn Ser Pro Ala Glu Asp 
145                 150                 155                 160 


Phe Gln Glu Pro Cys Gln Tyr Ser Gln Glu Ser Gln Lys Phe Ser Cys 
                165                 170                 175     


Gln Leu Ala Val Pro Glu Gly Asp Ser Ser Phe Tyr Ile Val Ser Met 
            180                 185                 190         


Cys Val Ala Ser Ser Val Gly Ser Lys Phe Ser Lys Thr Gln Thr Phe 
        195                 200                 205             


Gln Gly Cys Gly Ile Leu Gln Pro Asp Pro Pro Ala Asn Ile Thr Val 
    210                 215                 220                 


Thr Ala Val Ala Arg Asn Pro Arg Trp Leu Ser Val Thr Trp Gln Asp 
225                 230                 235                 240 


Pro His Ser Trp Asn Ser Ser Phe Tyr Arg Leu Arg Phe Glu Leu Arg 
                245                 250                 255     


Tyr Arg Ala Glu Arg Ser Lys Thr Phe Thr Thr Trp Met Val Lys Asp 
            260                 265                 270         


Leu Gln His His Cys Val Ile His Asp Ala Trp Ser Gly Leu Arg His 
        275                 280                 285             


Val Val Gln Leu Arg Ala Gln Glu Glu Phe Gly Gln Gly Glu Trp Ser 
    290                 295                 300                 


Glu Trp Ser Pro Glu Ala Met Gly Thr Pro Trp Thr Glu Ser Arg Ser 
305                 310                 315                 320 


Pro Pro Ala Glu Asn Glu Val Ser Thr Pro Met Gln Ala Leu Thr Thr 
                325                 330                 335     


Asn Lys Asp Asp Asp Asn Ile Leu Phe Arg Asp Ser Ala Asn Ala Thr 
            340                 345                 350         


Ser Leu Pro Gly Ser Arg Arg Arg Gly Ser Cys Gly Leu 
        355                 360                 365 


<210>  7125
<211>  468
<212>  PRT
<213>  Homo Sapiens

<400>  7125

Met Leu Ala Val Gly Cys Ala Leu Leu Ala Ala Leu Leu Ala Ala Pro 
1               5                   10                  15      


Gly Ala Ala Leu Ala Pro Arg Arg Cys Pro Ala Gln Glu Val Ala Arg 
            20                  25                  30          


Gly Val Leu Thr Ser Leu Pro Gly Asp Ser Val Thr Leu Thr Cys Pro 
        35                  40                  45              


Gly Val Glu Pro Glu Asp Asn Ala Thr Val His Trp Val Leu Arg Lys 
    50                  55                  60                  


Pro Ala Ala Gly Ser His Pro Ser Arg Trp Ala Gly Met Gly Arg Arg 
65                  70                  75                  80  


Leu Leu Leu Arg Ser Val Gln Leu His Asp Ser Gly Asn Tyr Ser Cys 
                85                  90                  95      


Tyr Arg Ala Gly Arg Pro Ala Gly Thr Val His Leu Leu Val Asp Val 
            100                 105                 110         


Pro Pro Glu Glu Pro Gln Leu Ser Cys Phe Arg Lys Ser Pro Leu Ser 
        115                 120                 125             


Asn Val Val Cys Glu Trp Gly Pro Arg Ser Thr Pro Ser Leu Thr Thr 
    130                 135                 140                 


Lys Ala Val Leu Leu Val Arg Lys Phe Gln Asn Ser Pro Ala Glu Asp 
145                 150                 155                 160 


Phe Gln Glu Pro Cys Gln Tyr Ser Gln Glu Ser Gln Lys Phe Ser Cys 
                165                 170                 175     


Gln Leu Ala Val Pro Glu Gly Asp Ser Ser Phe Tyr Ile Val Ser Met 
            180                 185                 190         


Cys Val Ala Ser Ser Val Gly Ser Lys Phe Ser Lys Thr Gln Thr Phe 
        195                 200                 205             


Gln Gly Cys Gly Ile Leu Gln Pro Asp Pro Pro Ala Asn Ile Thr Val 
    210                 215                 220                 


Thr Ala Val Ala Arg Asn Pro Arg Trp Leu Ser Val Thr Trp Gln Asp 
225                 230                 235                 240 


Pro His Ser Trp Asn Ser Ser Phe Tyr Arg Leu Arg Phe Glu Leu Arg 
                245                 250                 255     


Tyr Arg Ala Glu Arg Ser Lys Thr Phe Thr Thr Trp Met Val Lys Asp 
            260                 265                 270         


Leu Gln His His Cys Val Ile His Asp Ala Trp Ser Gly Leu Arg His 
        275                 280                 285             


Val Val Gln Leu Arg Ala Gln Glu Glu Phe Gly Gln Gly Glu Trp Ser 
    290                 295                 300                 


Glu Trp Ser Pro Glu Ala Met Gly Thr Pro Trp Thr Glu Ser Arg Ser 
305                 310                 315                 320 


Pro Pro Ala Glu Asn Glu Val Ser Thr Pro Met Gln Ala Leu Thr Thr 
                325                 330                 335     


Asn Lys Asp Asp Asp Asn Ile Leu Phe Arg Asp Ser Ala Asn Ala Thr 
            340                 345                 350         


Ser Leu Pro Val Gln Asp Ser Ser Ser Val Pro Leu Pro Thr Phe Leu 
        355                 360                 365             


Val Ala Gly Gly Ser Leu Ala Phe Gly Thr Leu Leu Cys Ile Ala Ile 
    370                 375                 380                 


Val Leu Arg Phe Lys Lys Thr Trp Lys Leu Arg Ala Leu Lys Glu Gly 
385                 390                 395                 400 


Lys Thr Ser Met His Pro Pro Tyr Ser Leu Gly Gln Leu Val Pro Glu 
                405                 410                 415     


Arg Pro Arg Pro Thr Pro Val Leu Val Pro Leu Ile Ser Pro Pro Val 
            420                 425                 430         


Ser Pro Ser Ser Leu Gly Ser Asp Asn Thr Ser Ser His Asn Arg Pro 
        435                 440                 445             


Asp Ala Arg Asp Pro Arg Ser Pro Tyr Asp Ile Ser Asn Thr Asp Tyr 
    450                 455                 460                 


Phe Phe Pro Arg 
465             


<210>  7126
<211>  352
<212>  PRT
<213>  Homo Sapiens

<400>  7126

Met Leu Ala Val Gly Cys Ala Leu Leu Ala Ala Leu Leu Ala Ala Pro 
1               5                   10                  15      


Gly Ala Ala Leu Ala Pro Arg Arg Cys Pro Ala Gln Glu Val Ala Arg 
            20                  25                  30          


Gly Val Leu Thr Ser Leu Pro Gly Asp Ser Val Thr Leu Thr Cys Pro 
        35                  40                  45              


Gly Val Glu Pro Glu Asp Asn Ala Thr Val His Trp Val Leu Arg Lys 
    50                  55                  60                  


Pro Ala Ala Gly Ser His Pro Ser Arg Trp Ala Gly Met Gly Arg Arg 
65                  70                  75                  80  


Leu Leu Leu Arg Ser Val Gln Leu His Asp Ser Gly Asn Tyr Ser Cys 
                85                  90                  95      


Tyr Arg Ala Gly Arg Pro Ala Gly Thr Val His Leu Leu Val Asp Val 
            100                 105                 110         


Pro Pro Glu Glu Pro Gln Leu Ser Cys Phe Arg Lys Ser Pro Leu Ser 
        115                 120                 125             


Asn Val Val Cys Glu Trp Gly Pro Arg Ser Thr Pro Ser Leu Thr Thr 
    130                 135                 140                 


Lys Ala Val Leu Leu Val Arg Lys Phe Gln Asn Ser Pro Ala Glu Asp 
145                 150                 155                 160 


Phe Gln Glu Pro Cys Gln Tyr Ser Gln Glu Ser Gln Lys Phe Ser Cys 
                165                 170                 175     


Gln Leu Ala Val Pro Glu Gly Asp Ser Ser Phe Tyr Ile Val Ser Met 
            180                 185                 190         


Cys Val Ala Ser Ser Val Gly Ser Lys Phe Ser Lys Thr Gln Thr Phe 
        195                 200                 205             


Gln Gly Cys Gly Ile Leu Gln Pro Asp Pro Pro Ala Asn Ile Thr Val 
    210                 215                 220                 


Thr Ala Val Ala Arg Asn Pro Arg Trp Leu Ser Val Thr Trp Gln Asp 
225                 230                 235                 240 


Pro His Ser Trp Asn Ser Ser Phe Tyr Arg Leu Arg Phe Glu Leu Arg 
                245                 250                 255     


Tyr Arg Ala Glu Arg Ser Lys Thr Phe Thr Thr Trp Met Val Lys Asp 
            260                 265                 270         


Leu Gln His His Cys Val Ile His Asp Ala Trp Ser Gly Leu Arg His 
        275                 280                 285             


Val Val Gln Leu Arg Ala Gln Glu Glu Phe Gly Gln Gly Glu Trp Ser 
    290                 295                 300                 


Glu Trp Ser Pro Glu Ala Met Gly Thr Pro Trp Thr Asp Arg Leu Ser 
305                 310                 315                 320 


Pro Arg Cys Pro Gly Trp Ser Thr Ala Val Gln Ser Gln Leu Thr Ala 
                325                 330                 335     


Thr Ser Ala Ser Trp Val Gln Ala Ile Leu Pro Pro Gln Pro Pro Lys 
            340                 345                 350         


<210>  7127
<211>  190
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7127

Xaa Gly Ser Lys Phe Ser Lys Thr Gln Thr Phe Gln Gly Cys Gly Ile 
1               5                   10                  15      


Leu Gln Pro Asp Pro Pro Ala Asn Ile Thr Val Thr Ala Val Ala Arg 
            20                  25                  30          


Asn Pro Arg Trp Leu Ser Val Thr Trp Gln Asp Pro His Ser Trp Asn 
        35                  40                  45              


Ser Ser Phe Tyr Arg Leu Arg Phe Glu Leu Arg Tyr Arg Ala Glu Arg 
    50                  55                  60                  


Ser Lys Thr Phe Thr Thr Trp Met Val Lys Asp Leu Gln His His Cys 
65                  70                  75                  80  


Val Ile His Asp Ala Trp Ser Gly Leu Arg His Val Val Gln Leu Arg 
                85                  90                  95      


Ala Gln Glu Glu Phe Gly Gln Gly Glu Trp Ser Glu Trp Ser Pro Glu 
            100                 105                 110         


Ala Met Gly Thr Pro Trp Thr Glu Ser Arg Ser Pro Pro Ala Glu Asn 
        115                 120                 125             


Glu Val Ser Thr Pro Met Gln Ala Leu Thr Thr Asn Lys Asp Asp Asp 
    130                 135                 140                 


Asn Ile Leu Phe Arg Asp Ser Ala Asn Ala Thr Ser Leu Pro Val Gln 
145                 150                 155                 160 


Asp Ser Ser Ser Val Pro Leu Pro Thr Phe Leu Val Ala Gly Gly Ser 
                165                 170                 175     


Leu Ala Phe Gly Thr Leu Leu Cys Ile Ala Ile Val Leu Arg 
            180                 185                 190 


<210>  7128
<211>  294
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7128

Xaa Arg Arg Leu Leu Leu Arg Ser Val Gln Leu His Asp Ser Gly Asn 
1               5                   10                  15      


Tyr Ser Cys Tyr Arg Ala Gly Arg Pro Ala Gly Thr Val His Leu Leu 
            20                  25                  30          


Val Asp Val Pro Pro Glu Glu Pro Gln Leu Ser Cys Phe Arg Lys Ser 
        35                  40                  45              


Pro Leu Ser Asn Val Val Cys Glu Trp Gly Pro Arg Ser Thr Pro Ser 
    50                  55                  60                  


Leu Thr Thr Lys Ala Val Leu Leu Val Arg Lys Phe Gln Asn Ser Pro 
65                  70                  75                  80  


Ala Glu Asp Phe Gln Glu Pro Cys Gln Tyr Ser Gln Glu Ser Gln Lys 
                85                  90                  95      


Phe Ser Cys Gln Leu Ala Val Pro Glu Gly Asp Ser Ser Phe Tyr Ile 
            100                 105                 110         


Val Ser Met Cys Val Ala Ser Ser Val Gly Ser Lys Phe Ser Lys Thr 
        115                 120                 125             


Gln Thr Phe Gln Gly Cys Gly Ile Leu Gln Pro Asp Pro Pro Ala Asn 
    130                 135                 140                 


Ile Thr Val Thr Ala Val Ala Arg Asn Pro Arg Trp Leu Ser Val Thr 
145                 150                 155                 160 


Trp Gln Asp Pro His Ser Trp Asn Ser Ser Phe Tyr Arg Leu Arg Phe 
                165                 170                 175     


Glu Leu Arg Tyr Arg Ala Glu Arg Ser Lys Thr Phe Thr Thr Trp Met 
            180                 185                 190         


Val Lys Asp Leu Gln His His Cys Val Ile His Asp Ala Trp Ser Gly 
        195                 200                 205             


Leu Arg His Val Val Gln Leu Arg Ala Gln Glu Glu Phe Gly Gln Gly 
    210                 215                 220                 


Glu Trp Ser Glu Trp Ser Pro Glu Ala Met Gly Thr Pro Trp Thr Gly 
225                 230                 235                 240 


Phe Ser Pro Gln Thr Ile Pro Gly Gly Ile Trp Asp Pro Ala Gly Glu 
                245                 250                 255     


Ser Arg Ser Pro Pro Ala Glu Asn Glu Val Ser Thr Pro Met Gln Ala 
            260                 265                 270         


Leu Thr Thr Asn Lys Asp Asp Asp Asn Ile Leu Phe Arg Asp Ser Ala 
        275                 280                 285             


Asn Ala Thr Ser Leu Pro 
    290                 


<210>  7129
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  7129

Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Glu Leu Lys Asn Thr Ser Gly Leu Met Phe Gln 
            20                  25                  30          


Ile Leu Gln Arg Val Ile Leu Pro Ser Gly His Leu Thr Leu Leu Gln 
        35                  40                  45              


Gly Thr Ile Leu Ile Gln Lys Ile Lys Cys Ile Gln Met Ala Ile Ser 
    50                  55                  60                  


Leu Met 
65      


<210>  7130
<211>  918
<212>  PRT
<213>  Homo Sapiens

<400>  7130

Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser 
            20                  25                  30          


Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys 
        35                  40                  45              


Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr 
    50                  55                  60                  


Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr 
65                  70                  75                  80  


Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser 
                85                  90                  95      


Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu 
            100                 105                 110         


Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys 
        115                 120                 125             


Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys 
    130                 135                 140                 


Glu Trp Asp Gly Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu 
145                 150                 155                 160 


Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg 
                165                 170                 175     


Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val 
            180                 185                 190         


Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr 
        195                 200                 205             


Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro 
    210                 215                 220                 


Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu 
225                 230                 235                 240 


Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys 
                245                 250                 255     


Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile 
            260                 265                 270         


Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp 
        275                 280                 285             


Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu 
    290                 295                 300                 


Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile 
305                 310                 315                 320 


Thr Tyr Glu Asp Arg Pro Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile 
                325                 330                 335     


Asp Pro Ser His Thr Gln Gly Tyr Arg Thr Val Gln Leu Val Trp Lys 
            340                 345                 350         


Thr Leu Pro Pro Phe Glu Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val 
        355                 360                 365             


Thr Leu Thr Arg Trp Lys Ser His Leu Gln Asn Tyr Thr Val Asn Ala 
    370                 375                 380                 


Thr Lys Leu Thr Val Asn Leu Thr Asn Asp Arg Tyr Leu Ala Thr Leu 
385                 390                 395                 400 


Thr Val Arg Asn Leu Val Gly Lys Ser Asp Ala Ala Val Leu Thr Ile 
                405                 410                 415     


Pro Ala Cys Asp Phe Gln Ala Thr His Pro Val Met Asp Leu Lys Ala 
            420                 425                 430         


Phe Pro Lys Asp Asn Met Leu Trp Val Glu Trp Thr Thr Pro Arg Glu 
        435                 440                 445             


Ser Val Lys Lys Tyr Ile Leu Glu Trp Cys Val Leu Ser Asp Lys Ala 
    450                 455                 460                 


Pro Cys Ile Thr Asp Trp Gln Gln Glu Asp Gly Thr Val His Arg Thr 
465                 470                 475                 480 


Tyr Leu Arg Gly Asn Leu Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val 
                485                 490                 495     


Thr Pro Val Tyr Ala Asp Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala 
            500                 505                 510         


Tyr Leu Lys Gln Ala Pro Pro Ser Lys Gly Pro Thr Val Arg Thr Lys 
        515                 520                 525             


Lys Val Gly Lys Asn Glu Ala Val Leu Glu Trp Asp Gln Leu Pro Val 
    530                 535                 540                 


Asp Val Gln Asn Gly Phe Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr 
545                 550                 555                 560 


Ile Ile Gly Asn Glu Thr Ala Val Asn Val Asp Ser Ser His Thr Glu 
                565                 570                 575     


Tyr Thr Leu Ser Ser Leu Thr Ser Asp Thr Leu Tyr Met Val Arg Met 
            580                 585                 590         


Ala Ala Tyr Thr Asp Glu Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe 
        595                 600                 605             


Thr Thr Pro Lys Phe Ala Gln Gly Glu Ile Glu Ala Ile Val Val Pro 
    610                 615                 620                 


Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu Gly Val Leu Phe Cys 
625                 630                 635                 640 


Phe Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro 
                645                 650                 655     


Asp Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro 
            660                 665                 670         


Arg His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp Gly Asn Phe 
        675                 680                 685             


Thr Asp Val Ser Val Val Glu Ile Glu Ala Asn Asp Lys Lys Pro Phe 
    690                 695                 700                 


Pro Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys Glu Lys Ile Asn 
705                 710                 715                 720 


Thr Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys Met Ser Ser 
                725                 730                 735     


Ser Arg Pro Ser Ile Ser Ser Ser Asp Glu Asn Glu Ser Ser Gln Asn 
            740                 745                 750         


Thr Ser Ser Thr Val Gln Tyr Ser Thr Val Val His Ser Gly Tyr Arg 
        755                 760                 765             


His Gln Val Pro Ser Val Gln Val Phe Ser Arg Ser Glu Ser Thr Gln 
    770                 775                 780                 


Pro Leu Leu Asp Ser Glu Glu Arg Pro Glu Asp Leu Gln Leu Val Asp 
785                 790                 795                 800 


His Val Asp Gly Gly Asp Gly Ile Leu Pro Arg Gln Gln Tyr Phe Lys 
                805                 810                 815     


Gln Asn Cys Ser Gln His Glu Ser Ser Pro Asp Ile Ser His Phe Glu 
            820                 825                 830         


Arg Ser Lys Gln Val Ser Ser Val Asn Glu Glu Asp Phe Val Arg Leu 
        835                 840                 845             


Lys Gln Gln Ile Ser Asp His Ile Ser Gln Ser Cys Gly Ser Gly Gln 
    850                 855                 860                 


Met Lys Met Phe Gln Glu Val Ser Ala Ala Asp Ala Phe Gly Pro Gly 
865                 870                 875                 880 


Thr Glu Gly Gln Val Glu Arg Phe Glu Thr Val Gly Met Glu Ala Ala 
                885                 890                 895     


Thr Asp Glu Gly Met Pro Lys Ser Tyr Leu Pro Gln Thr Val Arg Gln 
            900                 905                 910         


Gly Gly Tyr Met Pro Gln 
        915             


<210>  7131
<211>  918
<212>  PRT
<213>  Homo Sapiens

<400>  7131

Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser 
            20                  25                  30          


Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys 
        35                  40                  45              


Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr 
    50                  55                  60                  


Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr 
65                  70                  75                  80  


Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser 
                85                  90                  95      


Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu 
            100                 105                 110         


Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys 
        115                 120                 125             


Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys 
    130                 135                 140                 


Glu Trp Asp Gly Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu 
145                 150                 155                 160 


Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg 
                165                 170                 175     


Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val 
            180                 185                 190         


Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr 
        195                 200                 205             


Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro 
    210                 215                 220                 


Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu 
225                 230                 235                 240 


Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys 
                245                 250                 255     


Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile 
            260                 265                 270         


Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp 
        275                 280                 285             


Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu 
    290                 295                 300                 


Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile 
305                 310                 315                 320 


Thr Tyr Glu Asp Arg Pro Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile 
                325                 330                 335     


Asp Pro Ser His Thr Gln Gly Tyr Arg Thr Val Gln Leu Val Trp Lys 
            340                 345                 350         


Thr Leu Pro Pro Phe Glu Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val 
        355                 360                 365             


Thr Leu Thr Arg Trp Lys Ser His Leu Gln Asn Tyr Thr Val Asn Ala 
    370                 375                 380                 


Thr Lys Leu Thr Val Asn Leu Thr Asn Asp Arg Tyr Leu Ala Thr Leu 
385                 390                 395                 400 


Thr Val Arg Asn Leu Val Gly Lys Ser Asp Ala Ala Val Leu Thr Ile 
                405                 410                 415     


Pro Ala Cys Asp Phe Gln Ala Thr His Pro Val Met Asp Leu Lys Ala 
            420                 425                 430         


Phe Pro Lys Asp Asn Met Leu Trp Val Glu Trp Thr Thr Pro Arg Glu 
        435                 440                 445             


Ser Val Lys Lys Tyr Ile Leu Glu Trp Cys Val Leu Ser Asp Lys Ala 
    450                 455                 460                 


Pro Cys Ile Thr Asp Trp Gln Gln Glu Asp Gly Thr Val His Arg Thr 
465                 470                 475                 480 


Tyr Leu Arg Gly Asn Leu Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val 
                485                 490                 495     


Thr Pro Val Tyr Ala Asp Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala 
            500                 505                 510         


Tyr Leu Lys Gln Ala Pro Pro Ser Lys Gly Pro Thr Val Arg Thr Lys 
        515                 520                 525             


Lys Val Gly Lys Asn Glu Ala Val Leu Glu Trp Asp Gln Leu Pro Val 
    530                 535                 540                 


Asp Val Gln Asn Gly Phe Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr 
545                 550                 555                 560 


Ile Ile Gly Asn Glu Thr Ala Val Asn Val Asp Ser Ser His Thr Glu 
                565                 570                 575     


Tyr Thr Leu Ser Ser Leu Thr Ser Asp Thr Leu Tyr Met Val Arg Met 
            580                 585                 590         


Ala Ala Tyr Thr Asp Glu Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe 
        595                 600                 605             


Thr Thr Pro Lys Phe Ala Gln Gly Glu Ile Glu Ala Ile Val Val Pro 
    610                 615                 620                 


Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu Gly Val Leu Phe Cys 
625                 630                 635                 640 


Phe Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro 
                645                 650                 655     


Asp Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro 
            660                 665                 670         


Arg His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp Gly Asn Phe 
        675                 680                 685             


Thr Asp Val Ser Val Val Glu Ile Glu Ala Asn Asp Lys Lys Pro Phe 
    690                 695                 700                 


Pro Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys Glu Lys Ile Asn 
705                 710                 715                 720 


Thr Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys Met Ser Ser 
                725                 730                 735     


Ser Arg Pro Ser Ile Ser Ser Ser Asp Glu Asn Glu Ser Ser Gln Asn 
            740                 745                 750         


Thr Ser Ser Thr Val Gln Tyr Ser Thr Val Val His Ser Gly Tyr Arg 
        755                 760                 765             


His Gln Val Pro Ser Val Gln Val Phe Ser Arg Ser Glu Ser Thr Gln 
    770                 775                 780                 


Pro Leu Leu Asp Ser Glu Glu Arg Pro Glu Asp Leu Gln Leu Val Asp 
785                 790                 795                 800 


His Val Asp Gly Gly Asp Gly Ile Leu Pro Arg Gln Gln Tyr Phe Lys 
                805                 810                 815     


Gln Asn Cys Ser Gln His Glu Ser Ser Pro Asp Ile Ser His Phe Glu 
            820                 825                 830         


Arg Ser Lys Gln Val Ser Ser Val Asn Glu Glu Asp Phe Val Arg Leu 
        835                 840                 845             


Lys Gln Gln Ile Ser Asp His Ile Ser Gln Ser Cys Gly Ser Gly Gln 
    850                 855                 860                 


Met Lys Met Phe Gln Glu Val Ser Ala Ala Asp Ala Phe Gly Pro Gly 
865                 870                 875                 880 


Thr Glu Gly Gln Val Glu Arg Phe Glu Thr Val Gly Met Glu Ala Ala 
                885                 890                 895     


Thr Asp Glu Gly Met Pro Lys Ser Tyr Leu Pro Gln Thr Val Arg Gln 
            900                 905                 910         


Gly Gly Tyr Met Pro Gln 
        915             


<210>  7132
<211>  857
<212>  PRT
<213>  Homo Sapiens

<400>  7132

Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser 
            20                  25                  30          


Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys 
        35                  40                  45              


Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr 
    50                  55                  60                  


Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr 
65                  70                  75                  80  


Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser 
                85                  90                  95      


Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu 
            100                 105                 110         


Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys 
        115                 120                 125             


Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys 
    130                 135                 140                 


Glu Trp Asp Gly Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu 
145                 150                 155                 160 


Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg 
                165                 170                 175     


Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val 
            180                 185                 190         


Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr 
        195                 200                 205             


Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro 
    210                 215                 220                 


Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu 
225                 230                 235                 240 


Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys 
                245                 250                 255     


Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile 
            260                 265                 270         


Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp 
        275                 280                 285             


Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu 
    290                 295                 300                 


Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile 
305                 310                 315                 320 


Thr Tyr Glu Asp Arg Pro Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile 
                325                 330                 335     


Asp Pro Ser His Thr Gln Gly Tyr Arg Thr Val Gln Leu Val Trp Lys 
            340                 345                 350         


Thr Leu Pro Pro Phe Glu Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val 
        355                 360                 365             


Thr Leu Thr Arg Trp Lys Ser His Leu Gln Asn Tyr Thr Val Asn Ala 
    370                 375                 380                 


Thr Lys Leu Thr Val Asn Leu Thr Asn Asp Arg Tyr Leu Ala Thr Leu 
385                 390                 395                 400 


Thr Val Arg Asn Leu Val Gly Lys Ser Asp Ala Ala Val Leu Thr Ile 
                405                 410                 415     


Pro Ala Cys Asp Phe Gln Gly Asn Leu Ala Glu Ser Lys Cys Tyr Leu 
            420                 425                 430         


Ile Thr Val Thr Pro Val Tyr Ala Asp Gly Pro Gly Ser Pro Glu Ser 
        435                 440                 445             


Ile Lys Ala Tyr Leu Lys Gln Ala Pro Pro Ser Lys Gly Pro Thr Val 
    450                 455                 460                 


Arg Thr Lys Lys Val Gly Lys Asn Glu Ala Val Leu Glu Trp Asp Gln 
465                 470                 475                 480 


Leu Pro Val Asp Val Gln Asn Gly Phe Ile Arg Asn Tyr Thr Ile Phe 
                485                 490                 495     


Tyr Arg Thr Ile Ile Gly Asn Glu Thr Ala Val Asn Val Asp Ser Ser 
            500                 505                 510         


His Thr Glu Tyr Thr Leu Ser Ser Leu Thr Ser Asp Thr Leu Tyr Met 
        515                 520                 525             


Val Arg Met Ala Ala Tyr Thr Asp Glu Gly Gly Lys Asp Gly Pro Glu 
    530                 535                 540                 


Phe Thr Phe Thr Thr Pro Lys Phe Ala Gln Gly Glu Ile Glu Ala Ile 
545                 550                 555                 560 


Val Val Pro Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu Gly Val 
                565                 570                 575     


Leu Phe Cys Phe Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro 
            580                 585                 590         


Asn Val Pro Asp Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His 
        595                 600                 605             


Thr Pro Pro Arg His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp 
    610                 615                 620                 


Gly Asn Phe Thr Asp Val Ser Val Val Glu Ile Glu Ala Asn Asp Lys 
625                 630                 635                 640 


Lys Pro Phe Pro Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys Glu 
                645                 650                 655     


Lys Ile Asn Thr Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys 
            660                 665                 670         


Met Ser Ser Ser Arg Pro Ser Ile Ser Ser Ser Asp Glu Asn Glu Ser 
        675                 680                 685             


Ser Gln Asn Thr Ser Ser Thr Val Gln Tyr Ser Thr Val Val His Ser 
    690                 695                 700                 


Gly Tyr Arg His Gln Val Pro Ser Val Gln Val Phe Ser Arg Ser Glu 
705                 710                 715                 720 


Ser Thr Gln Pro Leu Leu Asp Ser Glu Glu Arg Pro Glu Asp Leu Gln 
                725                 730                 735     


Leu Val Asp His Val Asp Gly Gly Asp Gly Ile Leu Pro Arg Gln Gln 
            740                 745                 750         


Tyr Phe Lys Gln Asn Cys Ser Gln His Glu Ser Ser Pro Asp Ile Ser 
        755                 760                 765             


His Phe Glu Arg Ser Lys Gln Val Ser Ser Val Asn Glu Glu Asp Phe 
    770                 775                 780                 


Val Arg Leu Lys Gln Gln Ile Ser Asp His Ile Ser Gln Ser Cys Gly 
785                 790                 795                 800 


Ser Gly Gln Met Lys Met Phe Gln Glu Val Ser Ala Ala Asp Ala Phe 
                805                 810                 815     


Gly Pro Gly Thr Glu Gly Gln Val Glu Arg Phe Glu Thr Val Gly Met 
            820                 825                 830         


Glu Ala Ala Thr Asp Glu Gly Met Pro Lys Ser Tyr Leu Pro Gln Thr 
        835                 840                 845             


Val Arg Gln Gly Gly Tyr Met Pro Gln 
    850                 855         


<210>  7133
<211>  329
<212>  PRT
<213>  Homo Sapiens

<400>  7133

Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser 
            20                  25                  30          


Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys 
        35                  40                  45              


Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr 
    50                  55                  60                  


Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr 
65                  70                  75                  80  


Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser 
                85                  90                  95      


Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu 
            100                 105                 110         


Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys 
        115                 120                 125             


Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys 
    130                 135                 140                 


Glu Trp Asp Gly Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu 
145                 150                 155                 160 


Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg 
                165                 170                 175     


Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val 
            180                 185                 190         


Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr 
        195                 200                 205             


Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro 
    210                 215                 220                 


Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu 
225                 230                 235                 240 


Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys 
                245                 250                 255     


Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile 
            260                 265                 270         


Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp 
        275                 280                 285             


Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu 
    290                 295                 300                 


Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile 
305                 310                 315                 320 


Thr Tyr Glu Asp Asn Ile Ala Ser Phe 
                325                 


<210>  7134
<211>  918
<212>  PRT
<213>  Homo Sapiens

<400>  7134

Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser 
            20                  25                  30          


Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys 
        35                  40                  45              


Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr 
    50                  55                  60                  


Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr 
65                  70                  75                  80  


Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser 
                85                  90                  95      


Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu 
            100                 105                 110         


Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys 
        115                 120                 125             


Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys 
    130                 135                 140                 


Glu Trp Asp Gly Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu 
145                 150                 155                 160 


Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg 
                165                 170                 175     


Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val 
            180                 185                 190         


Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr 
        195                 200                 205             


Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro 
    210                 215                 220                 


Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu 
225                 230                 235                 240 


Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys 
                245                 250                 255     


Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile 
            260                 265                 270         


Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp 
        275                 280                 285             


Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu 
    290                 295                 300                 


Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile 
305                 310                 315                 320 


Thr Tyr Glu Asp Arg Pro Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile 
                325                 330                 335     


Asp Pro Ser His Thr Gln Gly Tyr Arg Thr Val Gln Leu Val Trp Lys 
            340                 345                 350         


Thr Leu Pro Pro Phe Glu Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val 
        355                 360                 365             


Thr Leu Thr Arg Trp Lys Ser His Leu Gln Asn Tyr Thr Val Asn Ala 
    370                 375                 380                 


Thr Lys Leu Thr Val Asn Leu Thr Asn Asp Arg Tyr Leu Ala Thr Leu 
385                 390                 395                 400 


Thr Val Arg Asn Leu Val Gly Lys Ser Asp Ala Ala Val Leu Thr Ile 
                405                 410                 415     


Pro Ala Cys Asp Phe Gln Ala Thr His Pro Val Met Asp Leu Lys Ala 
            420                 425                 430         


Phe Pro Lys Asp Asn Met Leu Trp Val Glu Trp Thr Thr Pro Arg Glu 
        435                 440                 445             


Ser Val Lys Lys Tyr Ile Leu Glu Trp Cys Val Leu Ser Asp Lys Ala 
    450                 455                 460                 


Pro Cys Ile Thr Asp Trp Gln Gln Glu Asp Gly Thr Val His Arg Thr 
465                 470                 475                 480 


Tyr Leu Arg Gly Asn Leu Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val 
                485                 490                 495     


Thr Pro Val Tyr Ala Asp Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala 
            500                 505                 510         


Tyr Leu Lys Gln Ala Pro Pro Ser Lys Gly Pro Thr Val Arg Thr Lys 
        515                 520                 525             


Lys Val Gly Lys Asn Glu Ala Val Leu Glu Trp Asp Gln Leu Pro Val 
    530                 535                 540                 


Asp Val Gln Asn Gly Phe Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr 
545                 550                 555                 560 


Ile Ile Gly Asn Glu Thr Ala Val Asn Val Asp Ser Ser His Thr Glu 
                565                 570                 575     


Tyr Thr Leu Ser Ser Leu Thr Ser Asp Thr Leu Tyr Met Val Arg Met 
            580                 585                 590         


Ala Ala Tyr Thr Asp Glu Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe 
        595                 600                 605             


Thr Thr Pro Lys Phe Ala Gln Gly Glu Ile Glu Ala Ile Val Val Pro 
    610                 615                 620                 


Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu Gly Val Leu Phe Cys 
625                 630                 635                 640 


Phe Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro 
                645                 650                 655     


Asp Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro 
            660                 665                 670         


Arg His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp Gly Asn Phe 
        675                 680                 685             


Thr Asp Val Ser Val Val Glu Ile Glu Ala Asn Asp Lys Lys Pro Phe 
    690                 695                 700                 


Pro Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys Glu Lys Ile Asn 
705                 710                 715                 720 


Thr Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys Met Ser Ser 
                725                 730                 735     


Ser Arg Pro Ser Ile Ser Ser Ser Asp Glu Asn Glu Ser Ser Gln Asn 
            740                 745                 750         


Thr Ser Ser Thr Val Gln Tyr Ser Thr Val Val His Ser Gly Tyr Arg 
        755                 760                 765             


His Gln Val Pro Ser Val Gln Val Phe Ser Arg Ser Glu Ser Thr Gln 
    770                 775                 780                 


Pro Leu Leu Asp Ser Glu Glu Arg Pro Glu Asp Leu Gln Leu Val Asp 
785                 790                 795                 800 


His Val Asp Gly Gly Asp Gly Ile Leu Pro Arg Gln Gln Tyr Phe Lys 
                805                 810                 815     


Gln Asn Cys Ser Gln His Glu Ser Ser Pro Asp Ile Ser His Phe Glu 
            820                 825                 830         


Arg Ser Lys Gln Val Ser Ser Val Asn Glu Glu Asp Phe Val Arg Leu 
        835                 840                 845             


Lys Gln Gln Ile Ser Asp His Ile Ser Gln Ser Cys Gly Ser Gly Gln 
    850                 855                 860                 


Met Lys Met Phe Gln Glu Val Ser Ala Ala Asp Ala Phe Gly Pro Gly 
865                 870                 875                 880 


Thr Glu Gly Gln Val Glu Arg Phe Glu Thr Val Gly Met Glu Ala Ala 
                885                 890                 895     


Thr Asp Glu Gly Met Pro Lys Ser Tyr Leu Pro Gln Thr Val Arg Gln 
            900                 905                 910         


Gly Gly Tyr Met Pro Gln 
        915             


<210>  7135
<211>  329
<212>  PRT
<213>  Homo Sapiens

<400>  7135

Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser 
            20                  25                  30          


Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys 
        35                  40                  45              


Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr 
    50                  55                  60                  


Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr 
65                  70                  75                  80  


Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser 
                85                  90                  95      


Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu 
            100                 105                 110         


Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys 
        115                 120                 125             


Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys 
    130                 135                 140                 


Glu Trp Asp Gly Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu 
145                 150                 155                 160 


Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg 
                165                 170                 175     


Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val 
            180                 185                 190         


Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr 
        195                 200                 205             


Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro 
    210                 215                 220                 


Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu 
225                 230                 235                 240 


Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys 
                245                 250                 255     


Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile 
            260                 265                 270         


Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp 
        275                 280                 285             


Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu 
    290                 295                 300                 


Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile 
305                 310                 315                 320 


Thr Tyr Glu Asp Asn Ile Ala Ser Phe 
                325                 


<210>  7136
<211>  333
<212>  PRT
<213>  Homo Sapiens

<400>  7136

Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser 
            20                  25                  30          


Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys 
        35                  40                  45              


Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr 
    50                  55                  60                  


Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr 
65                  70                  75                  80  


Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser 
                85                  90                  95      


Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu 
            100                 105                 110         


Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys 
        115                 120                 125             


Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys 
    130                 135                 140                 


Glu Trp Asp Gly Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu 
145                 150                 155                 160 


Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg 
                165                 170                 175     


Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val 
            180                 185                 190         


Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr 
        195                 200                 205             


Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro 
    210                 215                 220                 


Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu 
225                 230                 235                 240 


Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys 
                245                 250                 255     


Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile 
            260                 265                 270         


Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp 
        275                 280                 285             


Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu 
    290                 295                 300                 


Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile 
305                 310                 315                 320 


Thr Tyr Glu Asp Thr Leu Asp Lys Pro Leu Gly Ser Gly 
                325                 330             


<210>  7137
<211>  203
<212>  PRT
<213>  Homo Sapiens

<400>  7137

Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser 
            20                  25                  30          


Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys 
        35                  40                  45              


Val Leu Lys Glu Lys Leu Lys Pro Asn Pro Pro His Asn Leu Ser Val 
    50                  55                  60                  


Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu Lys Leu Thr Trp Thr Asn 
65                  70                  75                  80  


Pro Ser Ile Lys Ser Val Ile Ile Leu Lys Tyr Asn Ile Gln Tyr Arg 
                85                  90                  95      


Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile Pro Pro Glu Asp Thr Ala 
            100                 105                 110         


Ser Thr Arg Ser Ser Phe Thr Val Gln Asp Leu Lys Pro Phe Thr Glu 
        115                 120                 125             


Tyr Val Phe Arg Ile Arg Cys Met Lys Glu Asp Gly Lys Gly Tyr Trp 
    130                 135                 140                 


Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile Thr Tyr Glu Asp Lys Leu 
145                 150                 155                 160 


Lys Asn Thr Ser Gly Leu Met Phe Gln Ile Leu Gln Arg Val Ile Leu 
                165                 170                 175     


Pro Ser Gly His Leu Thr Leu Leu Gln Gly Thr Ile Leu Ile Gln Lys 
            180                 185                 190         


Ile Lys Cys Ile Gln Met Ala Ile Ser Leu Met 
        195                 200             


<210>  7138
<211>  55
<212>  PRT
<213>  Homo Sapiens

<400>  7138

Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Gly Gln His Thr Ser Leu Leu Ile Ala Lys Gln 
            20                  25                  30          


Asn Val Thr Pro Pro Pro His Ala Leu Leu Ile Ile Leu Leu Cys Ile 
        35                  40                  45              


Leu Ser Thr Leu Lys Ser Gly 
    50                  55  


<210>  7139
<211>  115
<212>  PRT
<213>  Homo Sapiens

<400>  7139

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Glu Asn Lys 
65                  70                  75                  80  


Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg 
                85                  90                  95      


Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr 
            100                 105                 110         


Lys Glu His 
        115 


<210>  7140
<211>  159
<212>  PRT
<213>  Homo Sapiens

<400>  7140

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 
65                  70                  75                  80  


Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 
                85                  90                  95      


Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 
            100                 105                 110         


Ile Leu Leu Asn Cys Thr Gly Gln Glu Glu Asn Lys Ser Leu Lys Glu 
        115                 120                 125             


Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu 
    130                 135                 140                 


Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His 
145                 150                 155                 


<210>  7141
<211>  177
<212>  PRT
<213>  Homo Sapiens

<400>  7141

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 
65                  70                  75                  80  


Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 
                85                  90                  95      


Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 
            100                 105                 110         


Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala 
        115                 120                 125             


Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu 
    130                 135                 140                 


Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu 
145                 150                 155                 160 


Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu 
                165                 170                 175     


His 
    


<210>  7142
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  7142

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Val Lys Gly Arg 
65                  70                  75                  80  


Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu 
                85                  90                  95      


Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu 
            100                 105                 110         


Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met 
        115                 120                 125             


Gly Thr Lys Glu His 
    130             


<210>  7143
<211>  71
<212>  PRT
<213>  Homo Sapiens

<400>  7143

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asn Gln Pro Tyr Lys Lys Lys Glu Lys Arg Thr Glu Arg Lys Gln 
    50                  55                  60                  


Gln Ser Ala Met Ser Asn Asn 
65                  70      


<210>  7144
<211>  71
<212>  PRT
<213>  Homo Sapiens

<400>  7144

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asn Gln Pro Tyr Lys Lys Lys Glu Lys Arg Thr Glu Arg Lys Gln 
    50                  55                  60                  


Gln Ser Ala Met Ser Asn Asn 
65                  70      


<210>  7145
<211>  37
<212>  PRT
<213>  Homo Sapiens

<400>  7145

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Gln 
            20                  25                  30          


His Glu Arg Asn Trp 
        35          


<210>  7146
<211>  37
<212>  PRT
<213>  Homo Sapiens

<400>  7146

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Gln 
            20                  25                  30          


His Glu Arg Asn Trp 
        35          


<210>  7147
<211>  65
<212>  PRT
<213>  Homo Sapiens

<400>  7147

Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile Pro Asp His Tyr Phe 
1               5                   10                  15      


Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr Tyr Phe Arg Thr Pro 
            20                  25                  30          


Glu Ile Asn Asn Ser Ser Gly Leu Ser Leu Ser Tyr Gly Pro Val Ser 
        35                  40                  45              


Pro Ile Ile Arg Arg Leu Trp Asn Ile Phe Val Arg Asn Gln Glu Lys 
    50                  55                  60                  


Ile 
65  


<210>  7148
<211>  52
<212>  PRT
<213>  Homo Sapiens

<400>  7148

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln 
    50          


<210>  7149
<211>  59
<212>  PRT
<213>  Homo Sapiens

<400>  7149

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe 
    50                  55                  


<210>  7150
<211>  150
<212>  PRT
<213>  Homo Sapiens

<400>  7150

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                  55                  60                  


Asn Ile Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                  70                  75                  80  


Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                  90                  95      


Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                 105                 110         


Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Gly Lys 
        115                 120                 125             


Lys Leu Tyr Ile Lys Val Trp Leu Ser Leu Leu Gly Tyr Leu Lys Thr 
    130                 135                 140                 


Leu Cys Leu Asp Ile Leu 
145                 150 


<210>  7151
<211>  180
<212>  PRT
<213>  Homo Sapiens

<400>  7151

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                  55                  60                  


Asn Ile Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                  70                  75                  80  


Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                  90                  95      


Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                 105                 110         


Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys 
        115                 120                 125             


Pro Glu Ala Pro Phe Asp Leu Ser Val Val Tyr Arg Glu Gly Ala Asn 
    130                 135                 140                 


Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
145                 150                 155                 160 


Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn 
                165                 170                 175     


Lys Trp Thr Asp 
            180 


<210>  7152
<211>  459
<212>  PRT
<213>  Homo Sapiens

<400>  7152

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                  55                  60                  


Asn Ile Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                  70                  75                  80  


Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                  90                  95      


Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                 105                 110         


Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys 
        115                 120                 125             


Pro Glu Ala Pro Phe Asp Leu Ser Val Val Tyr Arg Glu Gly Ala Asn 
    130                 135                 140                 


Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
145                 150                 155                 160 


Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn 
                165                 170                 175     


Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln 
            180                 185                 190         


Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile 
        195                 200                 205             


Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr 
    210                 215                 220                 


Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro 
225                 230                 235                 240 


Ile Leu Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu 
                245                 250                 255     


Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val 
            260                 265                 270         


Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys 
        275                 280                 285             


Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu 
    290                 295                 300                 


Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val 
305                 310                 315                 320 


Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu 
                325                 330                 335     


Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu 
            340                 345                 350         


Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr 
        355                 360                 365             


Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser 
    370                 375                 380                 


Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val 
385                 390                 395                 400 


Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro 
                405                 410                 415     


Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala 
            420                 425                 430         


Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala 
        435                 440                 445             


Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
    450                 455                 


<210>  7153
<211>  261
<212>  PRT
<213>  Homo Sapiens

<400>  7153

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                  55                  60                  


Asn Ile Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                  70                  75                  80  


Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                  90                  95      


Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                 105                 110         


Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys 
        115                 120                 125             


Pro Glu Ala Pro Phe Asp Leu Ser Val Val Tyr Arg Glu Gly Ala Asn 
    130                 135                 140                 


Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
145                 150                 155                 160 


Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn 
                165                 170                 175     


Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln 
            180                 185                 190         


Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile 
        195                 200                 205             


Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr 
    210                 215                 220                 


Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Leu Ser Leu Ser 
225                 230                 235                 240 


Tyr Gly Pro Val Ser Pro Ile Ile Arg Arg Leu Trp Asn Ile Phe Val 
                245                 250                 255     


Arg Asn Gln Glu Lys 
            260     


<210>  7154
<211>  144
<212>  PRT
<213>  Homo Sapiens

<400>  7154

Met Leu Leu Ala Met Val Leu Thr Ser Ala Leu Leu Leu Cys Ser Val 
1               5                   10                  15      


Ala Gly Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe 
            20                  25                  30          


Leu Ile Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser 
        35                  40                  45              


Ala Asn Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys 
    50                  55                  60                  


Thr Arg Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr 
65                  70                  75                  80  


Met Gln Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val 
                85                  90                  95      


Glu Val Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro 
            100                 105                 110         


Cys Asn Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu 
        115                 120                 125             


Leu Glu Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile 
    130                 135                 140                 


<210>  7155
<211>  457
<212>  PRT
<213>  Homo Sapiens

<400>  7155

Met Ala Trp Pro Lys Leu Pro Ala Pro Trp Leu Leu Leu Cys Thr Trp 
1               5                   10                  15      


Leu Pro Ala Gly Cys Leu Ser Leu Leu Val Thr Val Gln His Thr Glu 
            20                  25                  30          


Arg Tyr Val Thr Leu Phe Ala Ser Ile Ile Leu Lys Cys Asp Tyr Thr 
        35                  40                  45              


Thr Ser Ala Gln Leu Gln Asp Val Val Val Thr Trp Arg Phe Lys Ser 
    50                  55                  60                  


Phe Cys Lys Asp Pro Ile Phe Asp Tyr Tyr Ser Ala Ser Tyr Gln Ala 
65                  70                  75                  80  


Ala Leu Ser Leu Gly Gln Asp Pro Ser Asn Asp Cys Asn Asp Asn Gln 
                85                  90                  95      


Arg Glu Val Arg Ile Val Ala Gln Arg Arg Gly Gln Asn Glu Pro Val 
            100                 105                 110         


Leu Gly Val Asp Tyr Arg Gln Arg Lys Ile Thr Ile Gln Asn Pro Leu 
        115                 120                 125             


Ala Arg His Arg Tyr Met Lys Gln Ala Gln Ala Leu Gly Pro Gln Met 
    130                 135                 140                 


Met Gly Lys Pro Leu Tyr Trp Gly Ala Asp Arg Ser Ser Gln Val Ser 
145                 150                 155                 160 


Ser Tyr Pro Met His Pro Leu Leu Gln Arg Asp Leu Ser Leu Pro Ser 
                165                 170                 175     


Ser Leu Pro Gln Met Pro Met Thr Gln Thr Thr Asn Gln Pro Pro Ile 
            180                 185                 190         


Ala Asn Gly Val Leu Glu Tyr Leu Glu Lys Glu Leu Arg Asn Leu Asn 
        195                 200                 205             


Leu Ala Gln Pro Leu Pro Pro Asp Leu Lys Gly Arg Phe Gly His Pro 
    210                 215                 220                 


Cys Ser Met Leu Ser Ser Leu Gly Ser Glu Val Val Glu Arg Arg Ile 
225                 230                 235                 240 


Ile His Leu Pro Pro Leu Ile Arg Asp Leu Ser Ser Ser Arg Arg Thr 
                245                 250                 255     


Ser Asp Ser Leu His Gln Gln Trp Leu Thr Pro Ile Pro Ser Arg Pro 
            260                 265                 270         


Trp Asp Leu Arg Glu Gly Arg Ser His His His Tyr Pro Asp Phe His 
        275                 280                 285             


Gln Glu Leu Gln Asp Arg Gly Pro Lys Ser Trp Ala Leu Glu Arg Arg 
    290                 295                 300                 


Glu Leu Asp Pro Ser Trp Ser Gly Arg His Arg Ser Ser Arg Leu Asn 
305                 310                 315                 320 


Gly Ser Pro Ile His Trp Ser Asp Arg Asp Ser Leu Ser Asp Val Pro 
                325                 330                 335     


Ser Ser Ser Glu Ala Arg Trp Arg Pro Ser His Pro Pro Phe Arg Ser 
            340                 345                 350         


Arg Cys Gln Glu Arg Pro Arg Arg Pro Ser Pro Arg Glu Ser Thr Gln 
        355                 360                 365             


Arg His Gly Arg Arg Arg Arg His Arg Ser Tyr Ser Pro Pro Leu Pro 
    370                 375                 380                 


Ser Gly Leu Ser Ser Trp Ser Ser Glu Glu Asp Lys Glu Arg Gln Pro 
385                 390                 395                 400 


Gln Ser Trp Arg Ala His Arg Arg Gly Ser His Ser Pro His Trp Pro 
                405                 410                 415     


Glu Glu Lys Pro Pro Ser Tyr Arg Ser Leu Asp Ile Thr Pro Gly Lys 
            420                 425                 430         


Asn Ser Arg Lys Lys Gly Ser Val Glu Arg Arg Ser Glu Lys Asp Ser 
        435                 440                 445             


Ser His Ser Gly Arg Ser Val Val Ile 
    450                 455         


<210>  7156
<211>  546
<212>  PRT
<213>  Homo Sapiens

<400>  7156

Met Ala Trp Pro Lys Leu Pro Ala Pro Trp Leu Leu Leu Cys Thr Trp 
1               5                   10                  15      


Leu Pro Ala Gly Cys Leu Ser Leu Leu Val Thr Val Gln His Thr Glu 
            20                  25                  30          


Arg Tyr Val Thr Leu Phe Ala Ser Ile Ile Leu Lys Cys Asp Tyr Thr 
        35                  40                  45              


Thr Ser Ala Gln Leu Gln Asp Val Val Val Thr Trp Arg Phe Lys Ser 
    50                  55                  60                  


Phe Cys Lys Asp Pro Ile Phe Asp Tyr Tyr Ser Ala Ser Tyr Gln Ala 
65                  70                  75                  80  


Ala Leu Ser Leu Gly Gln Asp Pro Ser Asn Asp Cys Asn Asp Asn Gln 
                85                  90                  95      


Arg Glu Val Arg Ile Val Ala Gln Arg Arg Gly Gln Asn Glu Pro Val 
            100                 105                 110         


Leu Gly Val Asp Tyr Arg Gln Arg Lys Ile Thr Ile Gln Asn Arg Ala 
        115                 120                 125             


Asp Leu Val Ile Asn Glu Val Met Trp Trp Asp His Gly Val Tyr Tyr 
    130                 135                 140                 


Cys Thr Ile Glu Ala Pro Gly Asp Thr Ser Gly Asp Pro Asp Lys Glu 
145                 150                 155                 160 


Val Lys Leu Ile Val Leu His Trp Leu Thr Val Ile Phe Ile Ile Leu 
                165                 170                 175     


Gly Ala Leu Leu Leu Leu Leu Leu Ile Gly Val Cys Trp Cys Gln Cys 
            180                 185                 190         


Cys Pro Gln Tyr Cys Cys Cys Tyr Ile Arg Cys Pro Cys Cys Pro Ala 
        195                 200                 205             


His Cys Cys Cys Pro Glu Glu Ala Leu Ala Arg His Arg Tyr Met Lys 
    210                 215                 220                 


Gln Ala Gln Ala Leu Gly Pro Gln Met Met Gly Lys Pro Leu Tyr Trp 
225                 230                 235                 240 


Gly Ala Asp Arg Ser Ser Gln Val Ser Ser Tyr Pro Met His Pro Leu 
                245                 250                 255     


Leu Gln Arg Asp Leu Ser Leu Pro Ser Ser Leu Pro Gln Met Pro Met 
            260                 265                 270         


Thr Gln Thr Thr Asn Gln Pro Pro Ile Ala Asn Gly Val Leu Glu Tyr 
        275                 280                 285             


Leu Glu Lys Glu Leu Arg Asn Leu Asn Leu Ala Gln Pro Leu Pro Pro 
    290                 295                 300                 


Asp Leu Lys Gly Arg Phe Gly His Pro Cys Ser Met Leu Ser Ser Leu 
305                 310                 315                 320 


Gly Ser Glu Val Val Glu Arg Arg Ile Ile His Leu Pro Pro Leu Ile 
                325                 330                 335     


Arg Asp Leu Ser Ser Ser Arg Arg Thr Ser Asp Ser Leu His Gln Gln 
            340                 345                 350         


Trp Leu Thr Pro Ile Pro Ser Arg Pro Trp Asp Leu Arg Glu Gly Arg 
        355                 360                 365             


Ser His His His Tyr Pro Asp Phe His Gln Glu Leu Gln Asp Arg Gly 
    370                 375                 380                 


Pro Lys Ser Trp Ala Leu Glu Arg Arg Glu Leu Asp Pro Ser Trp Ser 
385                 390                 395                 400 


Gly Arg His Arg Ser Ser Arg Leu Asn Gly Ser Pro Ile His Trp Ser 
                405                 410                 415     


Asp Arg Asp Ser Leu Ser Asp Val Pro Ser Ser Ser Glu Ala Arg Trp 
            420                 425                 430         


Arg Pro Ser His Pro Pro Phe Arg Ser Arg Cys Gln Glu Arg Pro Arg 
        435                 440                 445             


Arg Pro Ser Pro Arg Glu Ser Thr Gln Arg His Gly Arg Arg Arg Arg 
    450                 455                 460                 


His Arg Ser Tyr Ser Pro Pro Leu Pro Ser Gly Leu Ser Ser Trp Ser 
465                 470                 475                 480 


Ser Glu Glu Asp Lys Glu Arg Gln Pro Gln Ser Trp Arg Ala His Arg 
                485                 490                 495     


Arg Gly Ser His Ser Pro His Trp Pro Glu Glu Lys Pro Pro Ser Tyr 
            500                 505                 510         


Arg Ser Leu Asp Ile Thr Pro Gly Lys Asn Ser Arg Lys Lys Gly Ser 
        515                 520                 525             


Val Glu Arg Arg Ser Glu Lys Asp Ser Ser His Ser Gly Arg Ser Val 
    530                 535                 540                 


Val Ile 
545     


<210>  7157
<211>  546
<212>  PRT
<213>  Homo Sapiens

<400>  7157

Met Ala Trp Pro Lys Leu Pro Ala Pro Trp Leu Leu Leu Cys Thr Trp 
1               5                   10                  15      


Leu Pro Ala Gly Cys Leu Ser Leu Leu Val Thr Val Gln His Thr Glu 
            20                  25                  30          


Arg Tyr Val Thr Leu Phe Ala Ser Ile Ile Leu Lys Cys Asp Tyr Thr 
        35                  40                  45              


Thr Ser Ala Gln Leu Gln Asp Val Val Val Thr Trp Arg Phe Lys Ser 
    50                  55                  60                  


Phe Cys Lys Asp Pro Ile Phe Asp Tyr Tyr Ser Ala Ser Tyr Gln Ala 
65                  70                  75                  80  


Ala Leu Ser Leu Gly Gln Asp Pro Ser Asn Asp Cys Asn Asp Asn Gln 
                85                  90                  95      


Arg Glu Val Arg Ile Val Ala Gln Arg Arg Gly Gln Asn Glu Pro Val 
            100                 105                 110         


Leu Gly Val Asp Tyr Arg Gln Arg Lys Ile Thr Ile Gln Asn Arg Ala 
        115                 120                 125             


Asp Leu Val Ile Asn Glu Val Met Trp Trp Asp His Gly Val Tyr Tyr 
    130                 135                 140                 


Cys Thr Ile Glu Ala Pro Gly Asp Thr Ser Gly Asp Pro Asp Lys Glu 
145                 150                 155                 160 


Val Lys Leu Ile Val Leu His Trp Leu Thr Val Ile Phe Ile Ile Leu 
                165                 170                 175     


Gly Ala Leu Leu Leu Leu Leu Leu Ile Gly Val Cys Trp Cys Gln Cys 
            180                 185                 190         


Cys Pro Gln Tyr Cys Cys Cys Tyr Ile Arg Cys Pro Cys Cys Pro Ala 
        195                 200                 205             


His Cys Cys Cys Pro Glu Glu Ala Leu Ala Arg His Arg Tyr Met Lys 
    210                 215                 220                 


Gln Ala Gln Ala Leu Gly Pro Gln Met Met Gly Lys Pro Leu Tyr Trp 
225                 230                 235                 240 


Gly Ala Asp Arg Ser Ser Gln Val Ser Ser Tyr Pro Met His Pro Leu 
                245                 250                 255     


Leu Gln Arg Asp Leu Ser Leu Pro Ser Ser Leu Pro Gln Met Pro Met 
            260                 265                 270         


Thr Gln Thr Thr Asn Gln Pro Pro Ile Ala Asn Gly Val Leu Glu Tyr 
        275                 280                 285             


Leu Glu Lys Glu Leu Arg Asn Leu Asn Leu Ala Gln Pro Leu Pro Pro 
    290                 295                 300                 


Asp Leu Lys Gly Arg Phe Gly His Pro Cys Ser Met Leu Ser Ser Leu 
305                 310                 315                 320 


Gly Ser Glu Val Val Glu Arg Arg Ile Ile His Leu Pro Pro Leu Ile 
                325                 330                 335     


Arg Asp Leu Ser Ser Ser Arg Arg Thr Ser Asp Ser Leu His Gln Gln 
            340                 345                 350         


Trp Leu Thr Pro Ile Pro Ser Arg Pro Trp Asp Leu Arg Glu Gly Arg 
        355                 360                 365             


Ser His His His Tyr Pro Asp Phe His Gln Glu Leu Gln Asp Arg Gly 
    370                 375                 380                 


Pro Lys Ser Trp Ala Leu Glu Arg Arg Glu Leu Asp Pro Ser Trp Ser 
385                 390                 395                 400 


Gly Arg His Arg Ser Ser Arg Leu Asn Gly Ser Pro Ile His Trp Ser 
                405                 410                 415     


Asp Arg Asp Ser Leu Ser Asp Val Pro Ser Ser Ser Glu Ala Arg Trp 
            420                 425                 430         


Arg Pro Ser His Pro Pro Phe Arg Ser Arg Cys Gln Glu Arg Pro Arg 
        435                 440                 445             


Arg Pro Ser Pro Arg Glu Ser Thr Gln Arg His Gly Arg Arg Arg Arg 
    450                 455                 460                 


His Arg Ser Tyr Ser Pro Pro Leu Pro Ser Gly Leu Ser Ser Trp Ser 
465                 470                 475                 480 


Ser Glu Glu Asp Lys Glu Arg Gln Pro Gln Ser Trp Arg Ala His Arg 
                485                 490                 495     


Arg Gly Ser His Ser Pro His Trp Pro Glu Glu Lys Pro Pro Ser Tyr 
            500                 505                 510         


Arg Ser Leu Asp Ile Thr Pro Gly Lys Asn Ser Arg Lys Lys Gly Ser 
        515                 520                 525             


Val Glu Arg Arg Ser Glu Lys Asp Ser Ser His Ser Gly Arg Ser Val 
    530                 535                 540                 


Val Ile 
545     


<210>  7158
<211>  265
<212>  PRT
<213>  Homo Sapiens

<400>  7158

Met Ala Trp Pro Lys Leu Pro Ala Pro Trp Leu Leu Leu Cys Thr Trp 
1               5                   10                  15      


Leu Pro Ala Gly Cys Leu Ser Leu Leu Val Thr Val Gln His Thr Glu 
            20                  25                  30          


Arg Tyr Val Thr Leu Phe Ala Ser Ile Ile Leu Lys Cys Asp Tyr Thr 
        35                  40                  45              


Thr Ser Ala Gln Leu Gln Asp Val Val Val Thr Trp Arg Phe Lys Ser 
    50                  55                  60                  


Phe Cys Lys Asp Pro Ile Phe Asp Tyr Tyr Ser Ala Ser Tyr Gln Ala 
65                  70                  75                  80  


Ala Leu Ser Leu Gly Gln Asp Pro Ser Asn Asp Cys Asn Asp Asn Gln 
                85                  90                  95      


Arg Glu Val Arg Ile Val Ala Gln Arg Arg Gly Gln Asn Glu Pro Val 
            100                 105                 110         


Leu Gly Val Asp Tyr Arg Gln Arg Lys Ile Thr Ile Gln Asn Arg Ala 
        115                 120                 125             


Asp Leu Val Ile Asn Glu Val Met Trp Trp Asp His Gly Val Tyr Tyr 
    130                 135                 140                 


Cys Thr Ile Glu Ala Pro Gly Asp Thr Ser Gly Asp Pro Asp Lys Glu 
145                 150                 155                 160 


Val Lys Leu Ile Val Leu His Trp Leu Thr Val Ile Phe Ile Ile Leu 
                165                 170                 175     


Gly Ala Leu Leu Leu Leu Leu Leu Ile Gly Val Cys Trp Cys Gln Cys 
            180                 185                 190         


Cys Pro Gln Tyr Cys Cys Cys Tyr Ile Arg Cys Pro Cys Cys Pro Ala 
        195                 200                 205             


His Cys Cys Cys Pro Glu Glu Ala Leu Ala Arg His Arg Tyr Met Lys 
    210                 215                 220                 


Gln Ala Gln Ala Leu Gly Pro Gln Met Met Gly Lys Pro Leu Tyr Trp 
225                 230                 235                 240 


Gly Ala Asp Arg Ser Ser Gln Val Ser Ser Tyr Pro Met His Pro Leu 
                245                 250                 255     


Leu Gln Arg Ala Ser Arg Arg Cys Gln 
            260                 265 


<210>  7159
<211>  502
<212>  PRT
<213>  Homo Sapiens

<400>  7159

Met Ala Trp Pro Lys Leu Pro Ala Pro Trp Leu Leu Leu Cys Thr Trp 
1               5                   10                  15      


Leu Pro Ala Gly Cys Leu Ser Leu Leu Val Thr Val Gln His Thr Glu 
            20                  25                  30          


Arg Tyr Val Thr Leu Phe Ala Ser Ile Ile Leu Lys Cys Asp Tyr Thr 
        35                  40                  45              


Thr Ser Ala Gln Leu Gln Asp Val Val Val Thr Trp Arg Phe Lys Ser 
    50                  55                  60                  


Phe Cys Lys Asp Pro Ile Phe Asp Tyr Tyr Ser Ala Ser Tyr Gln Ala 
65                  70                  75                  80  


Ala Leu Ser Leu Gly Gln Asp Pro Ser Asn Asp Cys Asn Asp Asn Gln 
                85                  90                  95      


Arg Glu Val Arg Ile Val Ala Gln Arg Arg Gly Gln Asn Glu Pro Val 
            100                 105                 110         


Leu Gly Val Asp Tyr Arg Gln Arg Lys Ile Thr Ile Gln Asn Arg Ala 
        115                 120                 125             


Asp Leu Val Ile Asn Glu Val Met Trp Trp Asp His Gly Val Tyr Tyr 
    130                 135                 140                 


Cys Thr Ile Glu Ala Pro Gly Asp Thr Ser Gly Asp Pro Asp Lys Glu 
145                 150                 155                 160 


Val Lys Leu Ile Val Leu His Trp Leu Thr Val Ile Phe Ile Ile Leu 
                165                 170                 175     


Gly Ala Leu Leu Leu Leu Leu Leu Ile Gly Val Cys Trp Cys Gln Cys 
            180                 185                 190         


Cys Pro Gln Tyr Cys Cys Cys Tyr Ile Arg Cys Pro Cys Cys Pro Ala 
        195                 200                 205             


His Cys Cys Cys Pro Glu Glu Asp Leu Ser Leu Pro Ser Ser Leu Pro 
    210                 215                 220                 


Gln Met Pro Met Thr Gln Thr Thr Asn Gln Pro Pro Ile Ala Asn Gly 
225                 230                 235                 240 


Val Leu Glu Tyr Leu Glu Lys Glu Leu Arg Asn Leu Asn Leu Ala Gln 
                245                 250                 255     


Pro Leu Pro Pro Asp Leu Lys Gly Arg Phe Gly His Pro Cys Ser Met 
            260                 265                 270         


Leu Ser Ser Leu Gly Ser Glu Val Val Glu Arg Arg Ile Ile His Leu 
        275                 280                 285             


Pro Pro Leu Ile Arg Asp Leu Ser Ser Ser Arg Arg Thr Ser Asp Ser 
    290                 295                 300                 


Leu His Gln Gln Trp Leu Thr Pro Ile Pro Ser Arg Pro Trp Asp Leu 
305                 310                 315                 320 


Arg Glu Gly Arg Ser His His His Tyr Pro Asp Phe His Gln Glu Leu 
                325                 330                 335     


Gln Asp Arg Gly Pro Lys Ser Trp Ala Leu Glu Arg Arg Glu Leu Asp 
            340                 345                 350         


Pro Ser Trp Ser Gly Arg His Arg Ser Ser Arg Leu Asn Gly Ser Pro 
        355                 360                 365             


Ile His Trp Ser Asp Arg Asp Ser Leu Ser Asp Val Pro Ser Ser Ser 
    370                 375                 380                 


Glu Ala Arg Trp Arg Pro Ser His Pro Pro Phe Arg Ser Arg Cys Gln 
385                 390                 395                 400 


Glu Arg Pro Arg Arg Pro Ser Pro Arg Glu Ser Thr Gln Arg His Gly 
                405                 410                 415     


Arg Arg Arg Arg His Arg Ser Tyr Ser Pro Pro Leu Pro Ser Gly Leu 
            420                 425                 430         


Ser Ser Trp Ser Ser Glu Glu Asp Lys Glu Arg Gln Pro Gln Ser Trp 
        435                 440                 445             


Arg Ala His Arg Arg Gly Ser His Ser Pro His Trp Pro Glu Glu Lys 
    450                 455                 460                 


Pro Pro Ser Tyr Arg Ser Leu Asp Ile Thr Pro Gly Lys Asn Ser Arg 
465                 470                 475                 480 


Lys Lys Gly Ser Val Glu Arg Arg Ser Glu Lys Asp Ser Ser His Ser 
                485                 490                 495     


Gly Arg Ser Val Val Ile 
            500         


<210>  7160
<211>  167
<212>  PRT
<213>  Homo Sapiens

<400>  7160

Met Asp Arg Val Leu Leu Arg Trp Ile Ser Leu Phe Trp Leu Thr Ala 
1               5                   10                  15      


Met Val Glu Gly Leu Gln Val Thr Val Pro Asp Lys Lys Lys Val Ala 
            20                  25                  30          


Met Leu Phe Gln Pro Thr Val Leu Arg Cys His Phe Ser Thr Ser Ser 
        35                  40                  45              


His Gln Pro Ala Val Val Gln Trp Lys Phe Lys Ser Tyr Cys Gln Asp 
    50                  55                  60                  


Arg Met Gly Glu Ser Leu Gly Met Ser Ser Thr Arg Ala Gln Ser Leu 
65                  70                  75                  80  


Ser Lys Arg Asn Leu Glu Trp Asp Pro Tyr Leu Asp Cys Leu Asp Ser 
                85                  90                  95      


Arg Arg Thr Val Arg Val Val Ala Ser Lys Gln Gly Ser Thr Val Thr 
            100                 105                 110         


Leu Gly Asp Phe Tyr Arg Gly Arg Glu Ile Thr Ile Val His Asp Ala 
        115                 120                 125             


Asp Leu Gln Ile Gly Lys Leu Met Trp Gly Asp Ser Gly Leu Tyr Tyr 
    130                 135                 140                 


Cys Ile Ile Thr Thr Pro Asp Asp Leu Glu Gly Lys Asn Glu Asp Ser 
145                 150                 155                 160 


Val Glu Leu Leu Val Leu Glu 
                165         


<210>  7161
<211>  620
<212>  PRT
<213>  Homo Sapiens

<400>  7161

Met Asp Arg Val Leu Leu Arg Trp Ile Ser Leu Phe Trp Leu Thr Ala 
1               5                   10                  15      


Met Val Glu Gly Leu Gln Val Thr Val Pro Asp Lys Lys Lys Val Ala 
            20                  25                  30          


Met Leu Phe Gln Pro Thr Val Leu Arg Cys His Phe Ser Thr Ser Ser 
        35                  40                  45              


His Gln Pro Ala Val Val Gln Trp Lys Phe Lys Ser Tyr Cys Gln Asp 
    50                  55                  60                  


Arg Met Gly Glu Ser Leu Gly Met Ser Ser Thr Arg Ala Gln Ser Leu 
65                  70                  75                  80  


Ser Lys Arg Asn Leu Glu Trp Asp Pro Tyr Leu Asp Cys Leu Asp Ser 
                85                  90                  95      


Arg Arg Thr Val Arg Val Val Ala Ser Lys Gln Gly Ser Thr Val Thr 
            100                 105                 110         


Leu Gly Asp Phe Tyr Arg Gly Arg Glu Ile Thr Ile Val His Asp Ala 
        115                 120                 125             


Asp Leu Gln Ile Gly Lys Leu Met Trp Gly Asp Ser Gly Leu Tyr Tyr 
    130                 135                 140                 


Cys Ile Ile Thr Thr Pro Asp Asp Leu Glu Gly Lys Asn Glu Asp Ser 
145                 150                 155                 160 


Val Glu Leu Leu Val Leu Glu Trp Val Phe Val Gly Leu Val Leu Leu 
                165                 170                 175     


Gly Val Phe Leu Phe Phe Val Leu Val Gly Ile Cys Trp Cys Gln Cys 
            180                 185                 190         


Cys Pro His Ser Cys Cys Cys Tyr Val Arg Cys Pro Cys Cys Pro Asp 
        195                 200                 205             


Ser Cys Cys Cys Pro Gln Ala Leu Tyr Glu Ala Gly Lys Ala Ala Lys 
    210                 215                 220                 


Ala Gly Tyr Pro Pro Ser Val Ser Gly Val Pro Gly Pro Tyr Ser Ile 
225                 230                 235                 240 


Pro Ser Val Pro Leu Gly Gly Ala Pro Ser Ser Gly Met Leu Met Asp 
                245                 250                 255     


Lys Pro His Pro Pro Pro Leu Ala Pro Ser Asp Ser Thr Gly Gly Ser 
            260                 265                 270         


His Ser Val Arg Lys Gly Tyr Arg Ile Gln Ala Asp Lys Glu Arg Asp 
        275                 280                 285             


Ser Met Lys Val Leu Tyr Tyr Val Glu Lys Glu Leu Ala Gln Phe Asp 
    290                 295                 300                 


Pro Ala Arg Arg Met Arg Gly Arg Tyr Asn Asn Thr Ile Ser Glu Leu 
305                 310                 315                 320 


Ser Ser Leu His Glu Glu Asp Ser Asn Phe Arg Gln Ser Phe His Gln 
                325                 330                 335     


Met Arg Ser Lys Gln Phe Pro Val Ser Gly Asp Leu Glu Ser Asn Pro 
            340                 345                 350         


Asp Tyr Trp Ser Gly Val Met Gly Gly Ser Ser Gly Ala Ser Arg Gly 
        355                 360                 365             


Pro Ser Ala Met Glu Tyr Asn Lys Glu Asp Arg Glu Ser Phe Arg His 
    370                 375                 380                 


Ser Gln Pro Arg Ser Lys Ser Glu Met Leu Ser Arg Lys Asn Phe Ala 
385                 390                 395                 400 


Thr Gly Val Pro Ala Val Ser Met Asp Glu Leu Ala Ala Phe Ala Asp 
                405                 410                 415     


Ser Tyr Gly Gln Arg Pro Arg Arg Ala Asp Gly Asn Ser His Glu Ala 
            420                 425                 430         


Arg Gly Gly Ser Arg Phe Glu Arg Ser Glu Ser Arg Ala His Ser Gly 
        435                 440                 445             


Phe Tyr Gln Asp Asp Ser Leu Glu Glu Tyr Tyr Gly Gln Arg Ser Arg 
    450                 455                 460                 


Ser Arg Glu Pro Leu Thr Asp Ala Asp Arg Gly Trp Ala Phe Ser Pro 
465                 470                 475                 480 


Ala Arg Arg Arg Pro Ala Glu Asp Ala His Leu Pro Arg Leu Val Ser 
                485                 490                 495     


Arg Thr Pro Gly Thr Ala Pro Lys Tyr Asp His Ser Tyr Leu Gly Ser 
            500                 505                 510         


Ala Arg Glu Arg Gln Ala Arg Pro Glu Gly Ala Ser Arg Gly Gly Ser 
        515                 520                 525             


Leu Glu Thr Pro Ser Lys Arg Ser Ala Gln Leu Gly Pro Arg Ser Ala 
    530                 535                 540                 


Ser Tyr Tyr Ala Trp Ser Pro Pro Gly Thr Tyr Lys Ala Gly Ser Ser 
545                 550                 555                 560 


Gln Asp Asp Gln Glu Asp Ala Ser Asp Asp Ala Leu Pro Pro Tyr Ser 
                565                 570                 575     


Glu Leu Glu Leu Thr Arg Gly Pro Ser Tyr Arg Gly Arg Asp Leu Pro 
            580                 585                 590         


Tyr His Ser Asn Ser Glu Lys Lys Arg Lys Lys Glu Pro Ala Lys Lys 
        595                 600                 605             


Thr Asn Asp Phe Pro Thr Arg Met Ser Leu Val Val 
    610                 615                 620 


<210>  7162
<211>  580
<212>  PRT
<213>  Homo Sapiens

<400>  7162

Met Asp Arg Val Leu Leu Arg Trp Ile Ser Leu Phe Trp Leu Thr Ala 
1               5                   10                  15      


Met Val Glu Gly Leu Gln Val Thr Val Pro Asp Lys Lys Lys Val Ala 
            20                  25                  30          


Met Leu Phe Gln Pro Thr Val Leu Arg Cys His Phe Ser Thr Ser Ser 
        35                  40                  45              


His Gln Pro Ala Val Val Gln Trp Lys Phe Lys Ser Tyr Cys Gln Asp 
    50                  55                  60                  


Arg Met Gly Glu Ser Leu Gly Met Ser Ser Thr Arg Ala Gln Ser Leu 
65                  70                  75                  80  


Ser Lys Arg Asn Leu Glu Trp Asp Pro Tyr Leu Asp Cys Leu Asp Ser 
                85                  90                  95      


Arg Arg Thr Val Arg Val Val Ala Ser Lys Gln Gly Ser Thr Val Thr 
            100                 105                 110         


Leu Gly Asp Phe Tyr Arg Gly Arg Glu Ile Thr Ile Val His Asp Ala 
        115                 120                 125             


Asp Leu Gln Ile Gly Lys Leu Met Trp Gly Asp Ser Gly Leu Tyr Tyr 
    130                 135                 140                 


Cys Ile Ile Thr Thr Pro Asp Asp Leu Glu Gly Lys Asn Glu Asp Ser 
145                 150                 155                 160 


Val Glu Leu Leu Val Leu Gly Arg Thr Gly Leu Leu Ala Asp Leu Leu 
                165                 170                 175     


Pro Ser Phe Ala Val Glu Ile Met Pro Glu Trp Val Phe Val Gly Leu 
            180                 185                 190         


Val Leu Leu Gly Val Phe Leu Phe Phe Val Leu Val Gly Ile Cys Trp 
        195                 200                 205             


Cys Gln Cys Cys Pro His Ser Cys Cys Cys Tyr Val Arg Cys Pro Cys 
    210                 215                 220                 


Cys Pro Asp Ser Cys Cys Cys Pro Gln Ala Phe Arg Lys Gly Tyr Arg 
225                 230                 235                 240 


Ile Gln Ala Asp Lys Glu Arg Asp Ser Met Lys Val Leu Tyr Tyr Val 
                245                 250                 255     


Glu Lys Glu Leu Ala Gln Phe Asp Pro Ala Arg Arg Met Arg Gly Arg 
            260                 265                 270         


Tyr Asn Asn Thr Ile Ser Glu Leu Ser Ser Leu His Glu Glu Asp Ser 
        275                 280                 285             


Asn Phe Arg Gln Ser Phe His Gln Met Arg Ser Lys Gln Phe Pro Val 
    290                 295                 300                 


Ser Gly Asp Leu Glu Ser Asn Pro Asp Tyr Trp Ser Gly Val Met Gly 
305                 310                 315                 320 


Gly Ser Ser Gly Ala Ser Arg Gly Pro Ser Ala Met Glu Tyr Asn Lys 
                325                 330                 335     


Glu Asp Arg Glu Ser Phe Arg His Ser Gln Pro Arg Ser Lys Ser Glu 
            340                 345                 350         


Met Leu Ser Arg Lys Asn Phe Ala Thr Gly Val Pro Ala Val Ser Met 
        355                 360                 365             


Asp Glu Leu Ala Ala Phe Ala Asp Ser Tyr Gly Gln Arg Pro Arg Arg 
    370                 375                 380                 


Ala Asp Gly Asn Ser His Glu Ala Arg Gly Gly Ser Arg Phe Glu Arg 
385                 390                 395                 400 


Ser Glu Ser Arg Ala His Ser Gly Phe Tyr Gln Asp Asp Ser Leu Glu 
                405                 410                 415     


Glu Tyr Tyr Gly Gln Arg Ser Arg Ser Arg Glu Pro Leu Thr Asp Ala 
            420                 425                 430         


Asp Arg Gly Trp Ala Phe Ser Pro Ala Arg Arg Arg Pro Ala Glu Asp 
        435                 440                 445             


Ala His Leu Pro Arg Leu Val Ser Arg Thr Pro Gly Thr Ala Pro Lys 
    450                 455                 460                 


Tyr Asp His Ser Tyr Leu Gly Ser Ala Arg Glu Arg Gln Ala Arg Pro 
465                 470                 475                 480 


Glu Gly Ala Ser Arg Gly Gly Ser Leu Glu Thr Pro Ser Lys Arg Ser 
                485                 490                 495     


Ala Gln Leu Gly Pro Arg Ser Ala Ser Tyr Tyr Ala Trp Ser Pro Pro 
            500                 505                 510         


Gly Thr Tyr Lys Ala Gly Ser Ser Gln Asp Asp Gln Glu Asp Ala Ser 
        515                 520                 525             


Asp Asp Ala Leu Pro Pro Tyr Ser Glu Leu Glu Leu Thr Arg Gly Pro 
    530                 535                 540                 


Ser Tyr Arg Gly Arg Asp Leu Pro Tyr His Ser Asn Ser Glu Lys Lys 
545                 550                 555                 560 


Arg Lys Lys Glu Pro Ala Lys Lys Thr Asn Asp Phe Pro Thr Arg Met 
                565                 570                 575     


Ser Leu Val Val 
            580 


<210>  7163
<211>  639
<212>  PRT
<213>  Homo Sapiens

<400>  7163

Met Asp Arg Val Leu Leu Arg Trp Ile Ser Leu Phe Trp Leu Thr Ala 
1               5                   10                  15      


Met Val Glu Gly Leu Gln Val Thr Val Pro Asp Lys Lys Lys Val Ala 
            20                  25                  30          


Met Leu Phe Gln Pro Thr Val Leu Arg Cys His Phe Ser Thr Ser Ser 
        35                  40                  45              


His Gln Pro Ala Val Val Gln Trp Lys Phe Lys Ser Tyr Cys Gln Asp 
    50                  55                  60                  


Arg Met Gly Glu Ser Leu Gly Met Ser Ser Thr Arg Ala Gln Ser Leu 
65                  70                  75                  80  


Ser Lys Arg Asn Leu Glu Trp Asp Pro Tyr Leu Asp Cys Leu Asp Ser 
                85                  90                  95      


Arg Arg Thr Val Arg Val Val Ala Ser Lys Gln Gly Ser Thr Val Thr 
            100                 105                 110         


Leu Gly Asp Phe Tyr Arg Gly Arg Glu Ile Thr Ile Val His Asp Ala 
        115                 120                 125             


Asp Leu Gln Ile Gly Lys Leu Met Trp Gly Asp Ser Gly Leu Tyr Tyr 
    130                 135                 140                 


Cys Ile Ile Thr Thr Pro Asp Asp Leu Glu Gly Lys Asn Glu Asp Ser 
145                 150                 155                 160 


Val Glu Leu Leu Val Leu Gly Arg Thr Gly Leu Leu Ala Asp Leu Leu 
                165                 170                 175     


Pro Ser Phe Ala Val Glu Ile Met Pro Glu Trp Val Phe Val Gly Leu 
            180                 185                 190         


Val Leu Leu Gly Val Phe Leu Phe Phe Val Leu Val Gly Ile Cys Trp 
        195                 200                 205             


Cys Gln Cys Cys Pro His Ser Cys Cys Cys Tyr Val Arg Cys Pro Cys 
    210                 215                 220                 


Cys Pro Asp Ser Cys Cys Cys Pro Gln Ala Leu Tyr Glu Ala Gly Lys 
225                 230                 235                 240 


Ala Ala Lys Ala Gly Tyr Pro Pro Ser Val Ser Gly Val Pro Gly Pro 
                245                 250                 255     


Tyr Ser Ile Pro Ser Val Pro Leu Gly Gly Ala Pro Ser Ser Gly Met 
            260                 265                 270         


Leu Met Asp Lys Pro His Pro Pro Pro Leu Ala Pro Ser Asp Ser Thr 
        275                 280                 285             


Gly Gly Ser His Ser Val Arg Lys Gly Tyr Arg Ile Gln Ala Asp Lys 
    290                 295                 300                 


Glu Arg Asp Ser Met Lys Val Leu Tyr Tyr Val Glu Lys Glu Leu Ala 
305                 310                 315                 320 


Gln Phe Asp Pro Ala Arg Arg Met Arg Gly Arg Tyr Asn Asn Thr Ile 
                325                 330                 335     


Ser Glu Leu Ser Ser Leu His Glu Glu Asp Ser Asn Phe Arg Gln Ser 
            340                 345                 350         


Phe His Gln Met Arg Ser Lys Gln Phe Pro Val Ser Gly Asp Leu Glu 
        355                 360                 365             


Ser Asn Pro Asp Tyr Trp Ser Gly Val Met Gly Gly Ser Ser Gly Ala 
    370                 375                 380                 


Ser Arg Gly Pro Ser Ala Met Glu Tyr Asn Lys Glu Asp Arg Glu Ser 
385                 390                 395                 400 


Phe Arg His Ser Gln Pro Arg Ser Lys Ser Glu Met Leu Ser Arg Lys 
                405                 410                 415     


Asn Phe Ala Thr Gly Val Pro Ala Val Ser Met Asp Glu Leu Ala Ala 
            420                 425                 430         


Phe Ala Asp Ser Tyr Gly Gln Arg Pro Arg Arg Ala Asp Gly Asn Ser 
        435                 440                 445             


His Glu Ala Arg Gly Gly Ser Arg Phe Glu Arg Ser Glu Ser Arg Ala 
    450                 455                 460                 


His Ser Gly Phe Tyr Gln Asp Asp Ser Leu Glu Glu Tyr Tyr Gly Gln 
465                 470                 475                 480 


Arg Ser Arg Ser Arg Glu Pro Leu Thr Asp Ala Asp Arg Gly Trp Ala 
                485                 490                 495     


Phe Ser Pro Ala Arg Arg Arg Pro Ala Glu Asp Ala His Leu Pro Arg 
            500                 505                 510         


Leu Val Ser Arg Thr Pro Gly Thr Ala Pro Lys Tyr Asp His Ser Tyr 
        515                 520                 525             


Leu Gly Ser Ala Arg Glu Arg Gln Ala Arg Pro Glu Gly Ala Ser Arg 
    530                 535                 540                 


Gly Gly Ser Leu Glu Thr Pro Ser Lys Arg Ser Ala Gln Leu Gly Pro 
545                 550                 555                 560 


Arg Ser Ala Ser Tyr Tyr Ala Trp Ser Pro Pro Gly Thr Tyr Lys Ala 
                565                 570                 575     


Gly Ser Ser Gln Asp Asp Gln Glu Asp Ala Ser Asp Asp Ala Leu Pro 
            580                 585                 590         


Pro Tyr Ser Glu Leu Glu Leu Thr Arg Gly Pro Ser Tyr Arg Gly Arg 
        595                 600                 605             


Asp Leu Pro Tyr His Ser Asn Ser Glu Lys Lys Arg Lys Lys Glu Pro 
    610                 615                 620                 


Ala Lys Lys Thr Asn Asp Phe Pro Thr Arg Met Ser Leu Val Val 
625                 630                 635                 


<210>  7164
<211>  437
<212>  PRT
<213>  Homo Sapiens

<400>  7164

Met Asp Arg Val Leu Leu Arg Trp Ile Ser Leu Phe Trp Leu Thr Ala 
1               5                   10                  15      


Met Val Glu Gly Leu Gln Val Thr Val Pro Asp Lys Lys Lys Val Ala 
            20                  25                  30          


Met Leu Phe Gln Pro Thr Val Leu Arg Cys His Phe Ser Thr Ser Ser 
        35                  40                  45              


His Gln Pro Ala Val Val Gln Trp Lys Phe Lys Ser Tyr Cys Gln Asp 
    50                  55                  60                  


Arg Met Gly Glu Ser Leu Gly Met Ser Ser Thr Arg Ala Gln Ser Leu 
65                  70                  75                  80  


Ser Lys Arg Asn Leu Glu Trp Asp Pro Tyr Leu Asp Cys Leu Asp Ser 
                85                  90                  95      


Arg Arg Thr Val Arg Val Val Ala Ser Lys Gln Gly Ser Thr Val Thr 
            100                 105                 110         


Leu Gly Asp Phe Tyr Arg Gly Arg Glu Ile Thr Ile Val His Asp Ala 
        115                 120                 125             


Asp Leu Gln Ile Gly Lys Leu Met Trp Gly Asp Ser Gly Leu Tyr Tyr 
    130                 135                 140                 


Cys Ile Ile Thr Thr Pro Asp Asp Leu Glu Gly Lys Asn Glu Asp Ser 
145                 150                 155                 160 


Val Glu Leu Leu Val Leu Gly Arg Thr Gly Leu Leu Ala Asp Leu Leu 
                165                 170                 175     


Pro Ser Phe Ala Val Glu Ile Met Pro Glu Trp Val Phe Val Gly Leu 
            180                 185                 190         


Val Leu Leu Gly Val Phe Leu Phe Phe Val Leu Val Gly Ile Cys Trp 
        195                 200                 205             


Cys Gln Cys Cys Pro His Ser Cys Cys Cys Tyr Val Arg Cys Pro Cys 
    210                 215                 220                 


Cys Pro Asp Ser Cys Cys Cys Pro Gln Ala Leu Tyr Glu Ala Gly Lys 
225                 230                 235                 240 


Ala Ala Lys Ala Gly Tyr Pro Pro Ser Val Ser Gly Val Pro Gly Pro 
                245                 250                 255     


Tyr Ser Ile Pro Ser Val Pro Leu Gly Gly Ala Pro Ser Ser Gly Met 
            260                 265                 270         


Leu Met Asp Lys Pro His Pro Pro Pro Leu Ala Pro Ser Asp Ser Thr 
        275                 280                 285             


Gly Gly Ser His Ser Val Arg Lys Gly Tyr Arg Ile Gln Ala Asp Lys 
    290                 295                 300                 


Glu Arg Asp Ser Met Lys Val Leu Tyr Tyr Val Glu Lys Glu Leu Ala 
305                 310                 315                 320 


Gln Phe Asp Pro Ala Arg Arg Met Arg Gly Arg Tyr Asn Asn Thr Ile 
                325                 330                 335     


Ser Glu Leu Ser Ser Leu His Glu Glu Asp Ser Asn Phe Arg Gln Ser 
            340                 345                 350         


Phe His Gln Met Arg Ser Lys Gln Phe Pro Val Ser Gly Asp Leu Glu 
        355                 360                 365             


Ser Asn Pro Asp Tyr Trp Ser Gly Val Met Gly Gly Ser Ser Gly Ala 
    370                 375                 380                 


Ser Arg Gly Pro Ser Ala Met Glu Tyr Asn Lys Glu Asp Arg Glu Ser 
385                 390                 395                 400 


Phe Arg His Arg Met Thr Phe Gln Pro Gly Cys Pro Leu Trp Ser Asp 
                405                 410                 415     


Val Val Asn Ile Ser Leu Asp Asn Glu Lys Ser Asp Met Asp Tyr Gly 
            420                 425                 430         


Asp Lys Thr Gln Ile 
        435         


<210>  7165
<211>  531
<212>  PRT
<213>  Homo Sapiens

<400>  7165

Met Asp Arg Val Leu Leu Arg Trp Ile Ser Leu Phe Trp Leu Thr Ala 
1               5                   10                  15      


Met Val Glu Gly Leu Gln Val Thr Val Pro Asp Lys Lys Lys Val Ala 
            20                  25                  30          


Met Leu Phe Gln Pro Thr Val Leu Arg Cys His Phe Ser Thr Ser Ser 
        35                  40                  45              


His Gln Pro Ala Val Val Gln Trp Lys Phe Lys Ser Tyr Cys Gln Asp 
    50                  55                  60                  


Arg Met Gly Glu Ser Leu Gly Met Ser Ser Thr Arg Ala Gln Ser Leu 
65                  70                  75                  80  


Ser Lys Arg Asn Leu Glu Trp Asp Pro Tyr Leu Asp Cys Leu Asp Ser 
                85                  90                  95      


Arg Arg Thr Val Arg Val Val Ala Ser Lys Gln Gly Ser Thr Val Thr 
            100                 105                 110         


Leu Gly Asp Phe Tyr Arg Gly Arg Glu Ile Thr Ile Val His Asp Ala 
        115                 120                 125             


Asp Leu Gln Ile Gly Lys Leu Met Trp Gly Asp Ser Gly Leu Tyr Tyr 
    130                 135                 140                 


Cys Ile Ile Thr Thr Pro Asp Asp Leu Glu Gly Lys Asn Glu Asp Ser 
145                 150                 155                 160 


Val Glu Leu Leu Val Leu Gly Arg Thr Gly Leu Leu Ala Asp Leu Leu 
                165                 170                 175     


Pro Ser Phe Ala Val Glu Ile Met Pro Val Arg Lys Gly Tyr Arg Ile 
            180                 185                 190         


Gln Ala Asp Lys Glu Arg Asp Ser Met Lys Val Leu Tyr Tyr Val Glu 
        195                 200                 205             


Lys Glu Leu Ala Gln Phe Asp Pro Ala Arg Arg Met Arg Gly Arg Tyr 
    210                 215                 220                 


Asn Asn Thr Ile Ser Glu Leu Ser Ser Leu His Glu Glu Asp Ser Asn 
225                 230                 235                 240 


Phe Arg Gln Ser Phe His Gln Met Arg Ser Lys Gln Phe Pro Val Ser 
                245                 250                 255     


Gly Asp Leu Glu Ser Asn Pro Asp Tyr Trp Ser Gly Val Met Gly Gly 
            260                 265                 270         


Ser Ser Gly Ala Ser Arg Gly Pro Ser Ala Met Glu Tyr Asn Lys Glu 
        275                 280                 285             


Asp Arg Glu Ser Phe Arg His Ser Gln Pro Arg Ser Lys Ser Glu Met 
    290                 295                 300                 


Leu Ser Arg Lys Asn Phe Ala Thr Gly Val Pro Ala Val Ser Met Asp 
305                 310                 315                 320 


Glu Leu Ala Ala Phe Ala Asp Ser Tyr Gly Gln Arg Pro Arg Arg Ala 
                325                 330                 335     


Asp Gly Asn Ser His Glu Ala Arg Gly Gly Ser Arg Phe Glu Arg Ser 
            340                 345                 350         


Glu Ser Arg Ala His Ser Gly Phe Tyr Gln Asp Asp Ser Leu Glu Glu 
        355                 360                 365             


Tyr Tyr Gly Gln Arg Ser Arg Ser Arg Glu Pro Leu Thr Asp Ala Asp 
    370                 375                 380                 


Arg Gly Trp Ala Phe Ser Pro Ala Arg Arg Arg Pro Ala Glu Asp Ala 
385                 390                 395                 400 


His Leu Pro Arg Leu Val Ser Arg Thr Pro Gly Thr Ala Pro Lys Tyr 
                405                 410                 415     


Asp His Ser Tyr Leu Gly Ser Ala Arg Glu Arg Gln Ala Arg Pro Glu 
            420                 425                 430         


Gly Ala Ser Arg Gly Gly Ser Leu Glu Thr Pro Ser Lys Arg Ser Ala 
        435                 440                 445             


Gln Leu Gly Pro Arg Ser Ala Ser Tyr Tyr Ala Trp Ser Pro Pro Gly 
    450                 455                 460                 


Thr Tyr Lys Ala Gly Ser Ser Gln Asp Asp Gln Glu Asp Ala Ser Asp 
465                 470                 475                 480 


Asp Ala Leu Pro Pro Tyr Ser Glu Leu Glu Leu Thr Arg Gly Pro Ser 
                485                 490                 495     


Tyr Arg Gly Arg Asp Leu Pro Tyr His Ser Asn Ser Glu Lys Lys Arg 
            500                 505                 510         


Lys Lys Glu Pro Ala Lys Lys Thr Asn Asp Phe Pro Thr Arg Met Ser 
        515                 520                 525             


Leu Val Val 
    530     


<210>  7166
<211>  512
<212>  PRT
<213>  Homo Sapiens

<400>  7166

Met Asp Arg Val Leu Leu Arg Trp Ile Ser Leu Phe Trp Leu Thr Ala 
1               5                   10                  15      


Met Val Glu Gly Leu Gln Val Thr Val Pro Asp Lys Lys Lys Val Ala 
            20                  25                  30          


Met Leu Phe Gln Pro Thr Val Leu Arg Cys His Phe Ser Thr Ser Ser 
        35                  40                  45              


His Gln Pro Ala Val Val Gln Trp Lys Phe Lys Ser Tyr Cys Gln Asp 
    50                  55                  60                  


Arg Met Gly Glu Ser Leu Gly Met Ser Ser Thr Arg Ala Gln Ser Leu 
65                  70                  75                  80  


Ser Lys Arg Asn Leu Glu Trp Asp Pro Tyr Leu Asp Cys Leu Asp Ser 
                85                  90                  95      


Arg Arg Thr Val Arg Val Val Ala Ser Lys Gln Gly Ser Thr Val Thr 
            100                 105                 110         


Leu Gly Asp Phe Tyr Arg Gly Arg Glu Ile Thr Ile Val His Asp Ala 
        115                 120                 125             


Asp Leu Gln Ile Gly Lys Leu Met Trp Gly Asp Ser Gly Leu Tyr Tyr 
    130                 135                 140                 


Cys Ile Ile Thr Thr Pro Asp Asp Leu Glu Gly Lys Asn Glu Asp Ser 
145                 150                 155                 160 


Val Glu Leu Leu Val Leu Val Arg Lys Gly Tyr Arg Ile Gln Ala Asp 
                165                 170                 175     


Lys Glu Arg Asp Ser Met Lys Val Leu Tyr Tyr Val Glu Lys Glu Leu 
            180                 185                 190         


Ala Gln Phe Asp Pro Ala Arg Arg Met Arg Gly Arg Tyr Asn Asn Thr 
        195                 200                 205             


Ile Ser Glu Leu Ser Ser Leu His Glu Glu Asp Ser Asn Phe Arg Gln 
    210                 215                 220                 


Ser Phe His Gln Met Arg Ser Lys Gln Phe Pro Val Ser Gly Asp Leu 
225                 230                 235                 240 


Glu Ser Asn Pro Asp Tyr Trp Ser Gly Val Met Gly Gly Ser Ser Gly 
                245                 250                 255     


Ala Ser Arg Gly Pro Ser Ala Met Glu Tyr Asn Lys Glu Asp Arg Glu 
            260                 265                 270         


Ser Phe Arg His Ser Gln Pro Arg Ser Lys Ser Glu Met Leu Ser Arg 
        275                 280                 285             


Lys Asn Phe Ala Thr Gly Val Pro Ala Val Ser Met Asp Glu Leu Ala 
    290                 295                 300                 


Ala Phe Ala Asp Ser Tyr Gly Gln Arg Pro Arg Arg Ala Asp Gly Asn 
305                 310                 315                 320 


Ser His Glu Ala Arg Gly Gly Ser Arg Phe Glu Arg Ser Glu Ser Arg 
                325                 330                 335     


Ala His Ser Gly Phe Tyr Gln Asp Asp Ser Leu Glu Glu Tyr Tyr Gly 
            340                 345                 350         


Gln Arg Ser Arg Ser Arg Glu Pro Leu Thr Asp Ala Asp Arg Gly Trp 
        355                 360                 365             


Ala Phe Ser Pro Ala Arg Arg Arg Pro Ala Glu Asp Ala His Leu Pro 
    370                 375                 380                 


Arg Leu Val Ser Arg Thr Pro Gly Thr Ala Pro Lys Tyr Asp His Ser 
385                 390                 395                 400 


Tyr Leu Gly Ser Ala Arg Glu Arg Gln Ala Arg Pro Glu Gly Ala Ser 
                405                 410                 415     


Arg Gly Gly Ser Leu Glu Thr Pro Ser Lys Arg Ser Ala Gln Leu Gly 
            420                 425                 430         


Pro Arg Ser Ala Ser Tyr Tyr Ala Trp Ser Pro Pro Gly Thr Tyr Lys 
        435                 440                 445             


Ala Gly Ser Ser Gln Asp Asp Gln Glu Asp Ala Ser Asp Asp Ala Leu 
    450                 455                 460                 


Pro Pro Tyr Ser Glu Leu Glu Leu Thr Arg Gly Pro Ser Tyr Arg Gly 
465                 470                 475                 480 


Arg Asp Leu Pro Tyr His Ser Asn Ser Glu Lys Lys Arg Lys Lys Glu 
                485                 490                 495     


Pro Ala Lys Lys Thr Asn Asp Phe Pro Thr Arg Met Ser Leu Val Val 
            500                 505                 510         


<210>  7167
<211>  172
<212>  PRT
<213>  Homo Sapiens

<400>  7167

Met Ile Thr Thr Ser Arg Asp Pro Ser Ser Arg Leu Lys Met Phe Ala 
1               5                   10                  15      


Lys Glu Leu Lys Leu Val Phe Pro Gly Ala Gln Arg Met Asn Arg Gly 
            20                  25                  30          


Arg His Glu Val Gly Ala Leu Val Arg Ala Cys Lys Ala Asn Gly Val 
        35                  40                  45              


Thr Asp Leu Leu Val Val His Glu His Arg Gly Thr Pro Val Gly Leu 
    50                  55                  60                  


Ile Val Ser His Leu Pro Phe Gly Pro Thr Ala Tyr Phe Thr Leu Cys 
65                  70                  75                  80  


Asn Val Val Met Arg His Asp Ile Pro Asp Leu Gly Thr Met Ser Glu 
                85                  90                  95      


Ala Lys Pro His Leu Ile Thr His Gly Phe Ser Ser Arg Leu Gly Lys 
            100                 105                 110         


Arg Val Ser Asp Ile Leu Arg Tyr Leu Phe Pro Val Pro Lys Asp Asp 
        115                 120                 125             


Ser His Arg Val Ile Thr Phe Ala Asn Gln Asp Asp Tyr Ile Ser Phe 
    130                 135                 140                 


Arg His His Val Tyr Lys Lys Thr Asp His Arg Asn Val Glu Leu Thr 
145                 150                 155                 160 


Glu Val Gly Pro Arg Phe Glu Leu Lys Leu Tyr Met 
                165                 170         


<210>  7168
<211>  76
<212>  PRT
<213>  Homo Sapiens

<400>  7168

Met Leu Arg Arg Glu Ala Arg Leu Arg Arg Glu Tyr Leu Tyr Arg Lys 
1               5                   10                  15      


Ala Arg Glu Glu Ala Gln Arg Ser Ala Gln Glu Arg Lys Glu Arg Leu 
            20                  25                  30          


Arg Arg Ala Leu Glu Glu Asn Arg Leu Ile Pro Thr Glu Leu Arg Arg 
        35                  40                  45              


Glu Ala Leu Ala Leu Gln Gly Ser Leu Glu Phe Asp Asp Ala Gly Gly 
    50                  55                  60                  


Glu Gly Asn Tyr Thr Arg Cys Asp Gln Pro Arg Gly 
65                  70                  75      


<210>  7169
<211>  248
<212>  PRT
<213>  Homo Sapiens

<400>  7169

Met Leu Arg Arg Glu Ala Arg Leu Arg Arg Glu Tyr Leu Tyr Arg Lys 
1               5                   10                  15      


Ala Arg Glu Glu Ala Gln Arg Ser Ala Gln Glu Arg Lys Glu Arg Leu 
            20                  25                  30          


Arg Arg Ala Leu Glu Glu Asn Arg Leu Ile Pro Thr Glu Leu Arg Arg 
        35                  40                  45              


Glu Ala Leu Ala Leu Gln Gly Ser Leu Glu Phe Asp Asp Ala Gly Gly 
    50                  55                  60                  


Glu Gly Val Thr Ser His Val Asp Asp Glu Tyr Arg Trp Ala Gly Val 
65                  70                  75                  80  


Glu Asp Pro Lys Val Met Ile Thr Thr Ser Arg Asp Pro Ser Ser Arg 
                85                  90                  95      


Leu Lys Met Phe Ala Lys Glu Leu Lys Leu Val Phe Pro Gly Ala Gln 
            100                 105                 110         


Arg Met Asn Arg Gly Arg His Glu Val Gly Ala Leu Val Arg Ala Cys 
        115                 120                 125             


Lys Ala Asn Gly Val Thr Asp Leu Leu Val Val His Glu His Arg Gly 
    130                 135                 140                 


Thr Pro Val Gly Leu Ile Val Ser His Leu Pro Phe Gly Pro Thr Ala 
145                 150                 155                 160 


Tyr Phe Thr Leu Cys Asn Val Val Met Arg His Asp Ile Pro Asp Leu 
                165                 170                 175     


Gly Thr Met Ser Glu Ala Lys Pro His Leu Ile Thr His Gly Phe Ser 
            180                 185                 190         


Ser Arg Leu Gly Lys Arg Val Ser Asp Ile Leu Arg Tyr Leu Phe Pro 
        195                 200                 205             


Val Pro Lys Asp Asp Ser His Arg Val Ile Thr Phe Ala Asn Gln Asp 
    210                 215                 220                 


Asp Tyr Ile Ser Phe Arg His His Val Tyr Lys Lys Thr Asp His Arg 
225                 230                 235                 240 


Asn Val Glu Leu Thr Glu Cys Thr 
                245             


<210>  7170
<211>  291
<212>  PRT
<213>  Homo Sapiens

<400>  7170

Met Leu Arg Arg Glu Ala Arg Leu Arg Arg Glu Tyr Leu Tyr Arg Lys 
1               5                   10                  15      


Ala Arg Glu Glu Ala Gln Arg Ser Ala Gln Glu Arg Lys Glu Arg Leu 
            20                  25                  30          


Arg Arg Ala Leu Glu Glu Asn Arg Leu Ile Pro Thr Glu Leu Arg Arg 
        35                  40                  45              


Glu Ala Leu Ala Leu Gln Gly Ser Leu Glu Phe Asp Asp Ala Gly Gly 
    50                  55                  60                  


Glu Gly Val Thr Ser His Val Asp Asp Glu Tyr Arg Trp Ala Gly Val 
65                  70                  75                  80  


Glu Asp Pro Lys Val Met Ile Thr Thr Ser Arg Asp Pro Ser Ser Arg 
                85                  90                  95      


Leu Lys Met Phe Ala Lys Glu Leu Lys Leu Val Phe Pro Gly Ala Gln 
            100                 105                 110         


Arg Met Asn Arg Gly Arg His Glu Val Gly Ala Leu Val Arg Ala Cys 
        115                 120                 125             


Lys Ala Asn Gly Val Thr Asp Leu Leu Val Val His Glu His Arg Gly 
    130                 135                 140                 


Thr Pro Val Gly Leu Ile Val Ser His Leu Pro Phe Gly Pro Thr Ala 
145                 150                 155                 160 


Tyr Phe Thr Leu Cys Asn Val Val Met Arg His Asp Ile Pro Asp Leu 
                165                 170                 175     


Gly Thr Met Ser Glu Ala Lys Pro His Leu Ile Thr His Gly Phe Ser 
            180                 185                 190         


Ser Arg Leu Gly Lys Arg Val Ser Asp Ile Leu Arg Tyr Leu Phe Pro 
        195                 200                 205             


Val Pro Lys Asp Asp Ser His Arg Val Ile Thr Phe Ala Asn Gln Asp 
    210                 215                 220                 


Asp Tyr Ile Ser Phe Arg His His Val Tyr Lys Lys Thr Asp His Arg 
225                 230                 235                 240 


Asn Val Glu Leu Thr Glu Val Gly Pro Arg Phe Glu Leu Lys Leu Tyr 
                245                 250                 255     


Met Ile Arg Leu Gly Thr Leu Glu Gln Glu Ala Thr Ala Asp Val Glu 
            260                 265                 270         


Trp Arg Trp His Pro Tyr Thr Asn Thr Ala Arg Lys Arg Val Phe Leu 
        275                 280                 285             


Ser Thr Glu 
    290     


<210>  7171
<211>  236
<212>  PRT
<213>  Homo Sapiens

<400>  7171

Met Met Leu Glu Val Lys Val Thr Ile Gln Gly Val Thr Ser His Val 
1               5                   10                  15      


Asp Asp Glu Tyr Arg Trp Ala Gly Val Glu Asp Pro Lys Val Met Ile 
            20                  25                  30          


Thr Thr Ser Arg Asp Pro Ser Ser Arg Leu Lys Met Phe Ala Lys Glu 
        35                  40                  45              


Leu Lys Leu Val Phe Pro Gly Ala Gln Arg Met Asn Arg Gly Arg His 
    50                  55                  60                  


Glu Val Gly Ala Leu Val Arg Ala Cys Lys Ala Asn Gly Val Thr Asp 
65                  70                  75                  80  


Leu Leu Val Val His Glu His Arg Gly Thr Pro Val Gly Leu Ile Val 
                85                  90                  95      


Ser His Leu Pro Phe Gly Pro Thr Ala Tyr Phe Thr Leu Cys Asn Val 
            100                 105                 110         


Val Met Arg His Asp Ile Pro Asp Leu Gly Thr Met Ser Glu Ala Lys 
        115                 120                 125             


Pro His Leu Ile Thr His Gly Phe Ser Ser Arg Leu Gly Lys Arg Val 
    130                 135                 140                 


Ser Asp Ile Leu Arg Tyr Leu Phe Pro Val Pro Lys Asp Asp Ser His 
145                 150                 155                 160 


Arg Val Ile Thr Phe Ala Asn Gln Asp Asp Tyr Ile Ser Phe Arg His 
                165                 170                 175     


His Val Tyr Lys Lys Thr Asp His Arg Asn Val Glu Leu Thr Glu Val 
            180                 185                 190         


Gly Pro Arg Phe Glu Leu Lys Leu Tyr Met Ile Arg Leu Gly Thr Leu 
        195                 200                 205             


Glu Gln Glu Ala Thr Ala Asp Val Glu Trp Arg Trp His Pro Tyr Thr 
    210                 215                 220                 


Asn Thr Ala Arg Lys Arg Val Phe Leu Ser Thr Glu 
225                 230                 235     


<210>  7172
<211>  280
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7172

Xaa Ser Lys Cys Leu Pro Ala Val Phe Leu Ala His Trp Val Leu Leu 
1               5                   10                  15      


Leu Val Leu Arg Val Phe Leu Pro Cys Asp Glu Asn Arg Leu Ile Pro 
            20                  25                  30          


Thr Glu Leu Arg Arg Glu Ala Leu Ala Leu Gln Gly Ser Leu Glu Phe 
        35                  40                  45              


Asp Asp Ala Gly Gly Glu Gly Val Thr Ser His Val Asp Asp Glu Tyr 
    50                  55                  60                  


Arg Trp Ala Gly Val Glu Asp Pro Lys Val Met Ile Thr Thr Ser Arg 
65                  70                  75                  80  


Asp Pro Ser Ser Arg Leu Lys Met Phe Ala Lys Glu Leu Lys Leu Val 
                85                  90                  95      


Phe Pro Gly Ala Gln Arg Met Asn Arg Gly Arg His Glu Val Gly Ala 
            100                 105                 110         


Leu Val Arg Ala Cys Lys Ala Asn Gly Val Thr Asp Leu Leu Val Val 
        115                 120                 125             


His Glu His Arg Gly Thr Pro Val Gly Leu Ile Val Ser His Leu Pro 
    130                 135                 140                 


Phe Gly Pro Thr Ala Tyr Phe Thr Leu Cys Asn Val Val Met Arg His 
145                 150                 155                 160 


Asp Ile Pro Asp Leu Gly Thr Met Ser Glu Ala Lys Pro His Leu Ile 
                165                 170                 175     


Thr His Gly Phe Ser Ser Arg Leu Gly Lys Arg Val Ser Asp Ile Leu 
            180                 185                 190         


Arg Tyr Leu Phe Pro Val Pro Lys Asp Asp Ser His Arg Val Ile Thr 
        195                 200                 205             


Phe Ala Asn Gln Asp Asp Tyr Ile Ser Phe Arg His His Val Tyr Lys 
    210                 215                 220                 


Lys Thr Asp His Arg Asn Val Glu Leu Thr Glu Val Gly Pro Arg Phe 
225                 230                 235                 240 


Glu Leu Lys Leu Tyr Met Ile Arg Leu Gly Thr Leu Glu Gln Glu Ala 
                245                 250                 255     


Thr Ala Asp Val Glu Trp Arg Trp His Pro Tyr Thr Asn Thr Ala Arg 
            260                 265                 270         


Lys Arg Val Phe Leu Ser Thr Glu 
        275                 280 


<210>  7173
<211>  158
<212>  PRT
<213>  Homo Sapiens

<400>  7173

Glu Arg Pro Asn Gly Thr Ser Ala Gln Pro Ala Gln Val Lys Pro Glu 
1               5                   10                  15      


Phe Tyr Arg Gln Ala Glu Leu Lys Pro Cys Pro Trp Thr Gly Ser Asn 
            20                  25                  30          


Gln Arg Arg Cys Ile Thr Phe Cys Pro Thr Pro Asp Gln Ala Asp Pro 
        35                  40                  45              


Cys Lys Phe Leu Ala Cys Gly Glu Phe Ala Gln Cys Val Lys Asn Glu 
    50                  55                  60                  


Arg Thr Glu Glu Ala Glu Cys Arg Cys Lys Pro Gly Tyr Asp Ser Gln 
65                  70                  75                  80  


Gly Ser Leu Asp Gly Leu Glu Pro Gly Leu Cys Gly Pro Gly Thr Lys 
                85                  90                  95      


Glu Cys Glu Val Leu Gln Gly Lys Gly Ala Pro Cys Arg Leu Pro Asp 
            100                 105                 110         


His Ser Glu Asn Gln Ala Tyr Lys Thr Ser Val Lys Lys Phe Gln Asn 
        115                 120                 125             


Gln Gln Asn Asn Lys Val Ile Ser Lys Arg Asn Ser Glu Leu Leu Thr 
    130                 135                 140                 


Val Glu Tyr Glu Glu Phe Asn His Gln Asp Trp Glu Gly Asn 
145                 150                 155             


<210>  7174
<211>  140
<212>  PRT
<213>  Homo Sapiens

<400>  7174

Met Lys Gln Ile Leu Asp Ser Leu Gln Ala Tyr Tyr Arg Leu Arg Val 
1               5                   10                  15      


Cys Gln Glu Ala Val Trp Glu Ala Tyr Arg Ile Phe Leu Asp Arg Ile 
            20                  25                  30          


Pro Asp Thr Gly Glu Tyr Gln Asp Trp Val Ser Ile Cys Gln Gln Glu 
        35                  40                  45              


Thr Phe Cys Leu Phe Asp Ile Gly Lys Asn Phe Ser Asn Ser Gln Glu 
    50                  55                  60                  


His Leu Asp Leu Leu Gln Gln Arg Ile Lys Gln Arg Ser Phe Pro Asp 
65                  70                  75                  80  


Arg Lys Asp Glu Ile Ser Ala Glu Lys Thr Leu Gly Glu Pro Gly Glu 
                85                  90                  95      


Thr Ile Val Ile Ser Thr Glu Lys Asn Lys Gly Lys Thr Lys Pro Phe 
            100                 105                 110         


Asn Ile Leu Gln Phe Gly Asn Asn His His Glu His Leu Leu Pro Ile 
        115                 120                 125             


Phe Cys Leu Leu Ser Ser Ile Ile Tyr Thr Tyr Tyr 
    130                 135                 140 


<210>  7175
<211>  797
<212>  PRT
<213>  Homo Sapiens

<400>  7175

Met Tyr Leu Glu Thr Arg Arg Ala Ile Phe Val Phe Trp Ile Phe Leu 
1               5                   10                  15      


Gln Val Gln Gly Thr Lys Asp Ile Ser Ile Asn Ile Tyr His Ser Glu 
            20                  25                  30          


Thr Lys Asp Ile Asp Asn Pro Pro Arg Asn Glu Thr Thr Glu Ser Thr 
        35                  40                  45              


Glu Lys Met Tyr Lys Met Ser Thr Met Arg Arg Ile Phe Asp Leu Ala 
    50                  55                  60                  


Lys His Arg Thr Lys Arg Ser Ala Phe Phe Pro Thr Gly Val Lys Val 
65                  70                  75                  80  


Cys Pro Gln Glu Ser Met Lys Gln Ile Leu Asp Ser Leu Gln Ala Tyr 
                85                  90                  95      


Tyr Arg Leu Arg Val Cys Gln Glu Ala Val Trp Glu Ala Tyr Arg Ile 
            100                 105                 110         


Phe Leu Asp Arg Ile Pro Asp Thr Gly Glu Tyr Gln Asp Trp Val Ser 
        115                 120                 125             


Ile Cys Gln Gln Glu Thr Phe Cys Leu Phe Asp Ile Gly Lys Asn Phe 
    130                 135                 140                 


Ser Asn Ser Gln Glu His Leu Asp Leu Leu Gln Gln Arg Ile Lys Gln 
145                 150                 155                 160 


Arg Ser Phe Pro Asp Arg Lys Asp Glu Ile Ser Ala Glu Lys Thr Leu 
                165                 170                 175     


Gly Glu Pro Gly Glu Thr Ile Val Ile Ser Thr Asp Val Ala Asn Val 
            180                 185                 190         


Ser Leu Gly Pro Phe Pro Leu Thr Pro Asp Asp Thr Leu Leu Asn Glu 
        195                 200                 205             


Ile Leu Asp Asn Thr Leu Asn Asp Thr Lys Met Pro Thr Thr Glu Arg 
    210                 215                 220                 


Glu Thr Glu Phe Ala Val Leu Glu Glu Gln Arg Val Glu Leu Ser Val 
225                 230                 235                 240 


Ser Leu Val Asn Gln Lys Phe Lys Ala Glu Leu Ala Asp Ser Gln Ser 
                245                 250                 255     


Pro Tyr Tyr Gln Glu Leu Ala Gly Lys Ser Gln Leu Gln Met Gln Lys 
            260                 265                 270         


Ile Phe Lys Lys Leu Pro Gly Phe Lys Lys Ile His Val Leu Gly Phe 
        275                 280                 285             


Arg Pro Lys Lys Glu Lys Asp Gly Ser Ser Ser Thr Glu Met Gln Leu 
    290                 295                 300                 


Thr Ala Ile Phe Lys Arg His Ser Ala Glu Ala Lys Ser Pro Ala Ser 
305                 310                 315                 320 


Asp Leu Leu Ser Phe Asp Ser Asn Lys Ile Glu Ser Glu Glu Val Tyr 
                325                 330                 335     


His Gly Thr Met Glu Glu Asp Lys Gln Pro Glu Ile Tyr Leu Thr Ala 
            340                 345                 350         


Thr Asp Leu Lys Arg Leu Ile Ser Lys Ala Leu Glu Glu Glu Gln Ser 
        355                 360                 365             


Leu Asp Val Gly Thr Ile Gln Phe Thr Asp Glu Ile Ala Gly Ser Leu 
    370                 375                 380                 


Pro Ala Phe Gly Pro Asp Thr Gln Ser Glu Leu Pro Thr Ser Phe Ala 
385                 390                 395                 400 


Val Ile Thr Glu Asp Ala Thr Leu Ser Pro Glu Leu Pro Pro Val Glu 
                405                 410                 415     


Pro Gln Leu Glu Thr Val Asp Gly Ala Glu His Gly Leu Pro Asp Thr 
            420                 425                 430         


Ser Trp Ser Pro Pro Ala Met Ala Ser Thr Ser Leu Ser Glu Ala Pro 
        435                 440                 445             


Pro Phe Phe Met Ala Ser Ser Ile Phe Ser Leu Thr Asp Gln Gly Thr 
    450                 455                 460                 


Thr Asp Thr Met Ala Thr Asp Gln Thr Met Leu Val Pro Gly Leu Thr 
465                 470                 475                 480 


Ile Pro Thr Ser Asp Tyr Ser Ala Ile Ser Gln Leu Ala Leu Gly Ile 
                485                 490                 495     


Ser His Pro Pro Ala Ser Ser Asp Asp Ser Arg Ser Ser Ala Gly Gly 
            500                 505                 510         


Glu Asp Met Val Arg His Leu Asp Glu Met Asp Leu Ser Asp Thr Pro 
        515                 520                 525             


Ala Pro Ser Glu Val Pro Glu Leu Ser Glu Tyr Val Ser Val Pro Asp 
    530                 535                 540                 


His Phe Leu Glu Asp Thr Thr Pro Val Ser Ala Leu Gln Tyr Ile Thr 
545                 550                 555                 560 


Thr Ser Ser Met Thr Ile Ala Pro Lys Gly Arg Glu Leu Val Val Phe 
                565                 570                 575     


Phe Ser Leu Arg Val Ala Asn Met Ala Phe Ser Asn Asp Leu Phe Asn 
            580                 585                 590         


Lys Ser Ser Leu Glu Tyr Arg Ala Leu Glu Gln Gln Phe Thr Gln Leu 
        595                 600                 605             


Leu Val Pro Tyr Leu Arg Ser Asn Leu Thr Gly Phe Lys Gln Leu Glu 
    610                 615                 620                 


Ile Leu Asn Phe Arg Asn Gly Ser Val Ile Val Asn Ser Lys Met Lys 
625                 630                 635                 640 


Phe Ala Lys Ser Val Pro Tyr Asn Leu Thr Lys Ala Val His Gly Val 
                645                 650                 655     


Leu Glu Asp Phe Arg Ser Ala Ala Ala Gln Gln Leu His Leu Glu Ile 
            660                 665                 670         


Asp Ser Tyr Ser Leu Asn Ile Glu Pro Ala Asp Gln Ala Asp Pro Cys 
        675                 680                 685             


Lys Phe Leu Ala Cys Gly Glu Phe Ala Gln Cys Val Lys Asn Glu Arg 
    690                 695                 700                 


Thr Glu Glu Ala Glu Cys Arg Cys Lys Pro Gly Tyr Asp Ser Gln Gly 
705                 710                 715                 720 


Ser Leu Asp Gly Leu Glu Pro Gly Leu Cys Gly Pro Gly Thr Lys Glu 
                725                 730                 735     


Cys Glu Val Leu Gln Gly Lys Gly Ala Pro Cys Arg Leu Pro Asp His 
            740                 745                 750         


Ser Glu Asn Gln Ala Tyr Lys Thr Ser Val Lys Lys Phe Gln Asn Gln 
        755                 760                 765             


Gln Asn Asn Lys Val Ile Ser Lys Arg Asn Ser Glu Leu Leu Thr Val 
    770                 775                 780                 


Glu Tyr Glu Glu Phe Asn His Gln Asp Trp Glu Gly Asn 
785                 790                 795         


<210>  7176
<211>  719
<212>  PRT
<213>  Homo Sapiens

<400>  7176

Met Tyr Leu Glu Thr Arg Arg Ala Ile Phe Val Phe Trp Ile Phe Leu 
1               5                   10                  15      


Gln Val Gln Gly Thr Lys Val Cys Gln Glu Ala Val Trp Glu Ala Tyr 
            20                  25                  30          


Arg Ile Phe Leu Asp Arg Ile Pro Asp Thr Gly Glu Tyr Gln Asp Trp 
        35                  40                  45              


Val Ser Ile Cys Gln Gln Glu Thr Phe Cys Leu Phe Asp Ile Gly Lys 
    50                  55                  60                  


Asn Phe Ser Asn Ser Gln Glu His Leu Asp Leu Leu Gln Gln Arg Ile 
65                  70                  75                  80  


Lys Gln Arg Ser Phe Pro Asp Arg Lys Asp Glu Ile Ser Ala Glu Lys 
                85                  90                  95      


Thr Leu Gly Glu Pro Gly Glu Thr Ile Val Ile Ser Thr Asp Val Ala 
            100                 105                 110         


Asn Val Ser Leu Gly Pro Phe Pro Leu Thr Pro Asp Asp Thr Leu Leu 
        115                 120                 125             


Asn Glu Ile Leu Asp Asn Thr Leu Asn Asp Thr Lys Met Pro Thr Thr 
    130                 135                 140                 


Glu Arg Glu Thr Glu Phe Ala Val Leu Glu Glu Gln Arg Val Glu Leu 
145                 150                 155                 160 


Ser Val Ser Leu Val Asn Gln Lys Phe Lys Ala Glu Leu Ala Asp Ser 
                165                 170                 175     


Gln Ser Pro Tyr Tyr Gln Glu Leu Ala Gly Lys Ser Gln Leu Gln Met 
            180                 185                 190         


Gln Lys Ile Phe Lys Lys Leu Pro Gly Phe Lys Lys Ile His Val Leu 
        195                 200                 205             


Gly Phe Arg Pro Lys Lys Glu Lys Asp Gly Ser Ser Ser Thr Glu Met 
    210                 215                 220                 


Gln Leu Thr Ala Ile Phe Lys Arg His Ser Ala Glu Ala Lys Ser Pro 
225                 230                 235                 240 


Ala Ser Asp Leu Leu Ser Phe Asp Ser Asn Lys Ile Glu Ser Glu Glu 
                245                 250                 255     


Val Tyr His Gly Thr Met Glu Glu Asp Lys Gln Pro Glu Ile Tyr Leu 
            260                 265                 270         


Thr Ala Thr Asp Leu Lys Arg Leu Ile Ser Lys Ala Leu Glu Glu Glu 
        275                 280                 285             


Gln Ser Leu Asp Val Gly Thr Ile Gln Phe Thr Asp Glu Ile Ala Gly 
    290                 295                 300                 


Ser Leu Pro Ala Phe Gly Pro Asp Thr Gln Ser Glu Leu Pro Thr Ser 
305                 310                 315                 320 


Phe Ala Val Ile Thr Glu Asp Ala Thr Leu Ser Pro Glu Leu Pro Pro 
                325                 330                 335     


Val Glu Pro Gln Leu Glu Thr Val Asp Gly Ala Glu His Gly Leu Pro 
            340                 345                 350         


Asp Thr Ser Trp Ser Pro Pro Ala Met Ala Ser Thr Ser Leu Ser Glu 
        355                 360                 365             


Ala Pro Pro Phe Phe Met Ala Ser Ser Ile Phe Ser Leu Thr Asp Gln 
    370                 375                 380                 


Gly Thr Thr Asp Thr Met Ala Thr Asp Gln Thr Met Leu Val Pro Gly 
385                 390                 395                 400 


Leu Thr Ile Pro Thr Ser Asp Tyr Ser Ala Ile Ser Gln Leu Ala Leu 
                405                 410                 415     


Gly Ile Ser His Pro Pro Ala Ser Ser Asp Asp Ser Arg Ser Ser Ala 
            420                 425                 430         


Gly Gly Glu Asp Met Val Arg His Leu Asp Glu Met Asp Leu Ser Asp 
        435                 440                 445             


Thr Pro Ala Pro Ser Glu Val Pro Glu Leu Ser Glu Tyr Val Ser Val 
    450                 455                 460                 


Pro Asp His Phe Leu Glu Asp Thr Thr Pro Val Ser Ala Leu Gln Tyr 
465                 470                 475                 480 


Ile Thr Thr Ser Ser Met Thr Ile Ala Pro Lys Gly Arg Glu Leu Val 
                485                 490                 495     


Val Phe Phe Ser Leu Arg Val Ala Asn Met Ala Phe Ser Asn Asp Leu 
            500                 505                 510         


Phe Asn Lys Ser Ser Leu Glu Tyr Arg Ala Leu Glu Gln Gln Phe Thr 
        515                 520                 525             


Gln Leu Leu Val Pro Tyr Leu Arg Ser Asn Leu Thr Gly Phe Lys Gln 
    530                 535                 540                 


Leu Glu Ile Leu Asn Phe Arg Asn Gly Ser Val Ile Val Asn Ser Lys 
545                 550                 555                 560 


Met Lys Phe Ala Lys Ser Val Pro Tyr Asn Leu Thr Lys Ala Val His 
                565                 570                 575     


Gly Val Leu Glu Asp Phe Arg Ser Ala Ala Ala Gln Gln Leu His Leu 
            580                 585                 590         


Glu Ile Asp Ser Tyr Ser Leu Asn Ile Glu Pro Ala Asp Gln Ala Asp 
        595                 600                 605             


Pro Cys Lys Phe Leu Ala Cys Gly Glu Phe Ala Gln Cys Val Lys Asn 
    610                 615                 620                 


Glu Arg Thr Glu Glu Ala Glu Cys Arg Cys Lys Pro Gly Tyr Asp Ser 
625                 630                 635                 640 


Gln Gly Ser Leu Asp Gly Leu Glu Pro Gly Leu Cys Gly Pro Gly Thr 
                645                 650                 655     


Lys Glu Cys Glu Val Leu Gln Gly Lys Gly Ala Pro Cys Arg Leu Pro 
            660                 665                 670         


Asp His Ser Glu Asn Gln Ala Tyr Lys Thr Ser Val Lys Lys Phe Gln 
        675                 680                 685             


Asn Gln Gln Asn Asn Lys Val Ile Ser Lys Arg Asn Ser Glu Leu Leu 
    690                 695                 700                 


Thr Val Glu Tyr Glu Glu Phe Asn His Gln Asp Trp Glu Gly Asn 
705                 710                 715                 


<210>  7177
<211>  366
<212>  PRT
<213>  Homo Sapiens

<400>  7177

Met Val Leu His Leu Leu Leu Phe Leu Leu Leu Thr Pro Gln Gly Gly 
1               5                   10                  15      


His Ser Cys Gln Gly Leu Glu Leu Ala Arg Glu Leu Val Leu Ala Lys 
            20                  25                  30          


Val Arg Ala Leu Phe Leu Asp Ala Leu Gly Pro Pro Ala Val Thr Arg 
        35                  40                  45              


Glu Gly Gly Asp Pro Gly Val Arg Arg Leu Pro Arg Arg His Ala Leu 
    50                  55                  60                  


Gly Gly Phe Thr His Arg Gly Ser Glu Pro Glu Glu Glu Glu Asp Val 
65                  70                  75                  80  


Ser Gln Ala Ile Leu Phe Pro Ala Thr Asp Ala Ser Cys Glu Asp Lys 
                85                  90                  95      


Ser Ala Ala Arg Gly Leu Ala Gln Glu Ala Glu Glu Gly Leu Phe Arg 
            100                 105                 110         


Tyr Met Phe Arg Pro Ser Gln His Thr Arg Ser Arg Gln Val Thr Ser 
        115                 120                 125             


Ala Gln Leu Trp Phe His Thr Gly Leu Asp Arg Gln Gly Thr Ala Ala 
    130                 135                 140                 


Ser Asn Ser Ser Glu Pro Leu Leu Gly Leu Leu Ala Leu Ser Pro Gly 
145                 150                 155                 160 


Gly Pro Val Ala Val Pro Met Ser Leu Gly His Ala Pro Pro His Trp 
                165                 170                 175     


Ala Val Leu His Leu Ala Thr Ser Ala Leu Ser Leu Leu Thr His Pro 
            180                 185                 190         


Val Leu Val Leu Leu Leu Arg Cys Pro Leu Cys Thr Cys Ser Ala Arg 
        195                 200                 205             


Pro Glu Ala Thr Pro Phe Leu Val Ala His Thr Arg Thr Arg Pro Pro 
    210                 215                 220                 


Ser Gly Gly Glu Arg Ala Arg Arg Ser Thr Pro Leu Met Ser Trp Pro 
225                 230                 235                 240 


Trp Ser Pro Ser Ala Leu Arg Leu Leu Gln Arg Pro Pro Glu Glu Pro 
                245                 250                 255     


Ala Ala His Ala Asn Cys His Arg Val Ala Leu Asn Ile Ser Phe Gln 
            260                 265                 270         


Glu Leu Gly Trp Glu Arg Trp Ile Val Tyr Pro Pro Ser Phe Ile Phe 
        275                 280                 285             


His Tyr Cys His Gly Gly Cys Gly Leu His Ile Pro Pro Asn Leu Ser 
    290                 295                 300                 


Leu Pro Val Pro Gly Ala Pro Pro Thr Pro Ala Gln Pro Tyr Ser Leu 
305                 310                 315                 320 


Leu Pro Gly Ala Gln Pro Cys Cys Ala Ala Leu Pro Gly Thr Met Arg 
                325                 330                 335     


Pro Leu His Val Arg Thr Thr Ser Asp Gly Gly Tyr Ser Phe Lys Tyr 
            340                 345                 350         


Glu Thr Val Pro Asn Leu Leu Thr Gln His Cys Ala Cys Ile 
        355                 360                 365     


<210>  7178
<211>  426
<212>  PRT
<213>  Homo Sapiens

<400>  7178

Met Pro Leu Leu Trp Leu Arg Gly Phe Leu Leu Ala Ser Cys Trp Ile 
1               5                   10                  15      


Ile Val Arg Ser Ser Pro Thr Pro Gly Ser Glu Gly His Ser Ala Ala 
            20                  25                  30          


Pro Asp Cys Pro Ser Cys Ala Leu Ala Ala Leu Pro Lys Asp Val Pro 
        35                  40                  45              


Asn Ser Gln Pro Glu Met Val Glu Ala Val Lys Lys His Ile Leu Asn 
    50                  55                  60                  


Met Leu His Leu Lys Lys Arg Pro Asp Val Thr Gln Pro Val Pro Lys 
65                  70                  75                  80  


Ala Ala Leu Leu Asn Ala Ile Arg Lys Leu His Val Gly Lys Val Gly 
                85                  90                  95      


Glu Asn Gly Tyr Val Glu Ile Glu Asp Asp Ile Gly Arg Arg Ala Glu 
            100                 105                 110         


Met Asn Glu Leu Met Glu Gln Thr Ser Glu Ile Ile Thr Phe Ala Glu 
        115                 120                 125             


Ser Gly Thr Ala Arg Lys Thr Leu His Phe Glu Ile Ser Lys Glu Gly 
    130                 135                 140                 


Ser Asp Leu Ser Val Val Glu Arg Ala Glu Val Trp Leu Phe Leu Lys 
145                 150                 155                 160 


Val Pro Lys Ala Asn Arg Thr Arg Thr Lys Val Thr Ile Arg Leu Phe 
                165                 170                 175     


Gln Gln Gln Lys His Pro Gln Gly Ser Leu Asp Thr Gly Glu Glu Ala 
            180                 185                 190         


Glu Glu Val Gly Leu Lys Gly Glu Arg Ser Glu Leu Leu Leu Ser Glu 
        195                 200                 205             


Lys Val Val Asp Ala Arg Lys Ser Thr Trp His Val Phe Pro Val Ser 
    210                 215                 220                 


Ser Ser Ile Gln Arg Leu Leu Asp Gln Gly Lys Ser Ser Leu Asp Val 
225                 230                 235                 240 


Arg Ile Ala Cys Glu Gln Cys Gln Glu Ser Gly Ala Ser Leu Val Leu 
                245                 250                 255     


Leu Gly Lys Lys Lys Lys Lys Glu Glu Glu Gly Glu Gly Lys Lys Lys 
            260                 265                 270         


Gly Gly Gly Glu Gly Gly Ala Gly Ala Asp Glu Glu Lys Glu Gln Ser 
        275                 280                 285             


His Arg Pro Phe Leu Met Leu Gln Ala Arg Gln Ser Glu Asp His Pro 
    290                 295                 300                 


His Arg Arg Arg Arg Arg Gly Leu Glu Cys Asp Gly Lys Val Asn Ile 
305                 310                 315                 320 


Cys Cys Lys Lys Gln Phe Phe Val Ser Phe Lys Asp Ile Gly Trp Asn 
                325                 330                 335     


Asp Trp Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly 
            340                 345                 350         


Glu Cys Pro Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe 
        355                 360                 365             


His Ser Thr Val Ile Asn His Tyr Arg Met Arg Gly His Ser Pro Phe 
    370                 375                 380                 


Ala Asn Leu Lys Ser Cys Cys Val Pro Thr Lys Leu Arg Pro Met Ser 
385                 390                 395                 400 


Met Leu Tyr Tyr Asp Asp Gly Gln Asn Ile Ile Lys Lys Asp Ile Gln 
                405                 410                 415     


Asn Met Ile Val Glu Glu Cys Gly Cys Ser 
            420                 425     


<210>  7179
<211>  426
<212>  PRT
<213>  Homo Sapiens

<400>  7179

Met Pro Leu Leu Trp Leu Arg Gly Phe Leu Leu Ala Ser Cys Trp Ile 
1               5                   10                  15      


Ile Val Arg Ser Ser Pro Thr Pro Gly Ser Glu Gly His Ser Ala Ala 
            20                  25                  30          


Pro Asp Cys Pro Ser Cys Ala Leu Ala Ala Leu Pro Lys Asp Val Pro 
        35                  40                  45              


Asn Ser Gln Pro Glu Met Val Glu Ala Val Lys Lys His Ile Leu Asn 
    50                  55                  60                  


Met Leu His Leu Lys Lys Arg Pro Asp Val Thr Gln Pro Val Pro Lys 
65                  70                  75                  80  


Ala Ala Leu Leu Asn Ala Ile Arg Lys Leu His Val Gly Lys Val Gly 
                85                  90                  95      


Glu Asn Gly Tyr Val Glu Ile Glu Asp Asp Ile Gly Arg Arg Ala Glu 
            100                 105                 110         


Met Asn Glu Leu Met Glu Gln Thr Ser Glu Ile Ile Thr Phe Ala Glu 
        115                 120                 125             


Ser Gly Thr Ala Arg Lys Thr Leu His Phe Glu Ile Ser Lys Glu Gly 
    130                 135                 140                 


Ser Asp Leu Ser Val Val Glu Arg Ala Glu Val Trp Leu Phe Leu Lys 
145                 150                 155                 160 


Val Pro Lys Ala Asn Arg Thr Arg Thr Lys Val Thr Ile Arg Leu Phe 
                165                 170                 175     


Gln Gln Gln Lys His Pro Gln Gly Ser Leu Asp Thr Gly Glu Glu Ala 
            180                 185                 190         


Glu Glu Val Gly Leu Lys Gly Glu Arg Ser Glu Leu Leu Leu Ser Glu 
        195                 200                 205             


Lys Val Val Asp Ala Arg Lys Ser Thr Trp His Val Phe Pro Val Ser 
    210                 215                 220                 


Ser Ser Ile Gln Arg Leu Leu Asp Gln Gly Lys Ser Ser Leu Asp Val 
225                 230                 235                 240 


Arg Ile Ala Cys Glu Gln Cys Gln Glu Ser Gly Ala Ser Leu Val Leu 
                245                 250                 255     


Leu Gly Lys Lys Lys Lys Lys Glu Glu Glu Gly Glu Gly Lys Lys Lys 
            260                 265                 270         


Gly Gly Gly Glu Gly Gly Ala Gly Ala Asp Glu Glu Lys Glu Gln Ser 
        275                 280                 285             


His Arg Pro Phe Leu Met Leu Gln Ala Arg Gln Ser Glu Asp His Pro 
    290                 295                 300                 


His Arg Arg Arg Arg Arg Gly Leu Glu Cys Asp Gly Lys Val Asn Ile 
305                 310                 315                 320 


Cys Cys Lys Lys Gln Phe Phe Val Ser Phe Lys Asp Ile Gly Trp Asn 
                325                 330                 335     


Asp Trp Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly 
            340                 345                 350         


Glu Cys Pro Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe 
        355                 360                 365             


His Ser Thr Val Ile Asn His Tyr Arg Met Arg Gly His Ser Pro Phe 
    370                 375                 380                 


Ala Asn Leu Lys Ser Cys Cys Val Pro Thr Lys Leu Arg Pro Met Ser 
385                 390                 395                 400 


Met Leu Tyr Tyr Asp Asp Gly Gln Asn Ile Ile Lys Lys Asp Ile Gln 
                405                 410                 415     


Asn Met Ile Val Glu Glu Cys Gly Cys Ser 
            420                 425     


<210>  7180
<211>  426
<212>  PRT
<213>  Homo Sapiens

<400>  7180

Met Pro Leu Leu Trp Leu Arg Gly Phe Leu Leu Ala Ser Cys Trp Ile 
1               5                   10                  15      


Ile Val Arg Ser Ser Pro Thr Pro Gly Ser Glu Gly His Ser Ala Ala 
            20                  25                  30          


Pro Asp Cys Pro Ser Cys Ala Leu Ala Ala Leu Pro Lys Asp Val Pro 
        35                  40                  45              


Asn Ser Gln Pro Glu Met Val Glu Ala Val Lys Lys His Ile Leu Asn 
    50                  55                  60                  


Met Leu His Leu Lys Lys Arg Pro Asp Val Thr Gln Pro Val Pro Lys 
65                  70                  75                  80  


Ala Ala Leu Leu Asn Ala Ile Arg Lys Leu His Val Gly Lys Val Gly 
                85                  90                  95      


Glu Asn Gly Tyr Val Glu Ile Glu Asp Asp Ile Gly Arg Arg Ala Glu 
            100                 105                 110         


Met Asn Glu Leu Met Glu Gln Thr Ser Glu Ile Ile Thr Phe Ala Glu 
        115                 120                 125             


Ser Gly Thr Ala Arg Lys Thr Leu His Phe Glu Ile Ser Lys Glu Gly 
    130                 135                 140                 


Ser Asp Leu Ser Val Val Glu Arg Ala Glu Val Trp Leu Phe Leu Lys 
145                 150                 155                 160 


Val Pro Lys Ala Asn Arg Thr Arg Thr Lys Val Thr Ile Arg Leu Phe 
                165                 170                 175     


Gln Gln Gln Lys His Pro Gln Gly Ser Leu Asp Thr Gly Glu Glu Ala 
            180                 185                 190         


Glu Glu Val Gly Leu Lys Gly Glu Arg Ser Glu Leu Leu Leu Ser Glu 
        195                 200                 205             


Lys Val Val Asp Ala Arg Lys Ser Thr Trp His Val Phe Pro Val Ser 
    210                 215                 220                 


Ser Ser Ile Gln Arg Leu Leu Asp Gln Gly Lys Ser Ser Leu Asp Val 
225                 230                 235                 240 


Arg Ile Ala Cys Glu Gln Cys Gln Glu Ser Gly Ala Ser Leu Val Leu 
                245                 250                 255     


Leu Gly Lys Lys Lys Lys Lys Glu Glu Glu Gly Glu Gly Lys Lys Lys 
            260                 265                 270         


Gly Gly Gly Glu Gly Gly Ala Gly Ala Asp Glu Glu Lys Glu Gln Ser 
        275                 280                 285             


His Arg Pro Phe Leu Met Leu Gln Ala Arg Gln Ser Glu Asp His Pro 
    290                 295                 300                 


His Arg Arg Arg Arg Arg Gly Leu Glu Cys Asp Gly Lys Val Asn Ile 
305                 310                 315                 320 


Cys Cys Lys Lys Gln Phe Phe Val Ser Phe Lys Asp Ile Gly Trp Asn 
                325                 330                 335     


Asp Trp Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly 
            340                 345                 350         


Glu Cys Pro Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe 
        355                 360                 365             


His Ser Thr Val Ile Asn His Tyr Arg Met Arg Gly His Ser Pro Phe 
    370                 375                 380                 


Ala Asn Leu Lys Ser Cys Cys Val Pro Thr Lys Leu Arg Pro Met Ser 
385                 390                 395                 400 


Met Leu Tyr Tyr Asp Asp Gly Gln Asn Ile Ile Lys Lys Asp Ile Gln 
                405                 410                 415     


Asn Met Ile Val Glu Glu Cys Gly Cys Ser 
            420                 425     


<210>  7181
<211>  407
<212>  PRT
<213>  Homo Sapiens

<400>  7181

Met Asp Gly Leu Pro Gly Arg Ala Leu Gly Ala Ala Cys Leu Leu Leu 
1               5                   10                  15      


Leu Ala Ala Gly Trp Leu Gly Pro Glu Ala Trp Gly Ser Pro Thr Pro 
            20                  25                  30          


Pro Pro Thr Pro Ala Ala Pro Pro Pro Pro Pro Pro Pro Gly Ser Pro 
        35                  40                  45              


Gly Gly Ser Gln Asp Thr Cys Thr Ser Cys Gly Gly Phe Arg Arg Pro 
    50                  55                  60                  


Glu Glu Leu Gly Arg Val Asp Gly Asp Phe Leu Glu Ala Val Lys Arg 
65                  70                  75                  80  


His Ile Leu Ser Arg Leu Gln Met Arg Gly Arg Pro Asn Ile Thr His 
                85                  90                  95      


Ala Val Pro Lys Ala Ala Met Val Thr Ala Leu Arg Lys Leu His Ala 
            100                 105                 110         


Gly Lys Val Arg Glu Asp Gly Arg Val Glu Ile Pro His Leu Asp Gly 
        115                 120                 125             


His Ala Ser Pro Gly Ala Asp Gly Gln Glu Arg Val Ser Glu Ile Ile 
    130                 135                 140                 


Ser Phe Ala Glu Thr Asp Gly Leu Ala Ser Ser Arg Val Arg Leu Tyr 
145                 150                 155                 160 


Phe Phe Ile Ser Asn Glu Gly Asn Gln Asn Leu Phe Val Val Gln Ala 
                165                 170                 175     


Ser Leu Trp Leu Tyr Leu Lys Leu Leu Pro Tyr Val Leu Glu Lys Gly 
            180                 185                 190         


Ser Arg Arg Lys Val Arg Val Lys Val Tyr Phe Gln Glu Gln Gly His 
        195                 200                 205             


Gly Asp Arg Trp Asn Met Val Glu Lys Arg Val Asp Leu Lys Arg Ser 
    210                 215                 220                 


Gly Trp His Thr Phe Pro Leu Thr Glu Ala Ile Gln Ala Leu Phe Glu 
225                 230                 235                 240 


Arg Gly Glu Arg Arg Leu Asn Leu Asp Val Gln Cys Asp Ser Cys Gln 
                245                 250                 255     


Glu Leu Ala Val Val Pro Val Phe Val Asp Pro Gly Glu Glu Ser His 
            260                 265                 270         


Arg Pro Phe Val Val Val Gln Ala Arg Leu Gly Asp Ser Arg His Arg 
        275                 280                 285             


Ile Arg Lys Arg Gly Leu Glu Cys Asp Gly Arg Thr Asn Leu Cys Cys 
    290                 295                 300                 


Arg Gln Gln Phe Phe Ile Asp Phe Arg Leu Ile Gly Trp Asn Asp Trp 
305                 310                 315                 320 


Ile Ile Ala Pro Thr Gly Tyr Tyr Gly Asn Tyr Cys Glu Gly Ser Cys 
                325                 330                 335     


Pro Ala Tyr Leu Ala Gly Val Pro Gly Ser Ala Ser Ser Phe His Thr 
            340                 345                 350         


Ala Val Val Asn Gln Tyr Arg Met Arg Gly Leu Asn Pro Gly Thr Val 
        355                 360                 365             


Asn Ser Cys Cys Ile Pro Thr Lys Leu Ser Thr Met Ser Met Leu Tyr 
    370                 375                 380                 


Phe Asp Asp Glu Tyr Asn Ile Val Lys Arg Asp Val Pro Asn Met Ile 
385                 390                 395                 400 


Val Glu Glu Cys Gly Cys Ala 
                405         


<210>  7182
<211>  352
<212>  PRT
<213>  Homo Sapiens

<400>  7182

Met Thr Ser Ser Leu Leu Leu Ala Phe Leu Leu Leu Ala Pro Thr Thr 
1               5                   10                  15      


Val Ala Thr Pro Arg Ala Gly Gly Gln Cys Pro Ala Cys Gly Gly Pro 
            20                  25                  30          


Thr Leu Glu Leu Glu Ser Gln Arg Glu Leu Leu Leu Asp Leu Ala Lys 
        35                  40                  45              


Arg Ser Ile Leu Asp Lys Leu His Leu Thr Gln Arg Pro Thr Leu Asn 
    50                  55                  60                  


Arg Pro Val Ser Arg Ala Ala Leu Arg Thr Ala Leu Gln His Leu His 
65                  70                  75                  80  


Gly Val Pro Gln Gly Ala Leu Leu Glu Asp Asn Arg Glu Gln Glu Cys 
                85                  90                  95      


Glu Ile Ile Ser Phe Ala Glu Thr Gly Leu Ser Thr Ile Asn Gln Thr 
            100                 105                 110         


Arg Leu Asp Phe His Phe Ser Ser Asp Arg Thr Ala Gly Asp Arg Glu 
        115                 120                 125             


Val Gln Gln Ala Ser Leu Met Phe Phe Val Gln Leu Pro Ser Asn Thr 
    130                 135                 140                 


Thr Trp Thr Leu Lys Val Arg Val Leu Val Leu Gly Pro His Asn Thr 
145                 150                 155                 160 


Asn Leu Thr Leu Ala Thr Gln Tyr Leu Leu Glu Val Asp Ala Ser Gly 
                165                 170                 175     


Trp His Gln Leu Pro Leu Gly Pro Glu Ala Gln Ala Ala Cys Ser Gln 
            180                 185                 190         


Gly His Leu Thr Leu Glu Leu Val Leu Glu Gly Gln Val Ala Gln Ser 
        195                 200                 205             


Ser Val Ile Leu Gly Gly Ala Ala His Arg Pro Phe Val Ala Ala Arg 
    210                 215                 220                 


Val Arg Val Gly Gly Lys His Gln Ile His Arg Arg Gly Ile Asp Cys 
225                 230                 235                 240 


Gln Gly Gly Ser Arg Met Cys Cys Arg Gln Glu Phe Phe Val Asp Phe 
                245                 250                 255     


Arg Glu Ile Gly Trp His Asp Trp Ile Ile Gln Pro Glu Gly Tyr Ala 
            260                 265                 270         


Met Asn Phe Cys Ile Gly Gln Cys Pro Leu His Ile Ala Gly Met Pro 
        275                 280                 285             


Gly Ile Ala Ala Ser Phe His Thr Ala Val Leu Asn Leu Leu Lys Ala 
    290                 295                 300                 


Asn Thr Ala Ala Gly Thr Thr Gly Gly Gly Ser Cys Cys Val Pro Thr 
305                 310                 315                 320 


Ala Arg Arg Pro Leu Ser Leu Leu Tyr Tyr Asp Arg Asp Ser Asn Ile 
                325                 330                 335     


Val Lys Thr Asp Ile Pro Asp Met Val Val Glu Ala Cys Gly Cys Ser 
            340                 345                 350         


<210>  7183
<211>  274
<212>  PRT
<213>  Homo Sapiens

<400>  7183

Met Glu Thr Ala Ala Ala Val Val Lys Leu Glu Arg Leu Glu Ala Ala 
1               5                   10                  15      


Leu Thr Arg Ala Leu Arg Arg Leu Gln Pro Gly Ser Val Ala Pro Gly 
            20                  25                  30          


Asn Gly Glu Glu Val Ile Ser Phe Ala Thr Val Thr Asp Ser Thr Ser 
        35                  40                  45              


Ala Tyr Ser Ser Leu Leu Thr Phe His Leu Ser Thr Pro Arg Ser His 
    50                  55                  60                  


His Leu Tyr His Ala Arg Leu Trp Leu His Val Leu Pro Thr Leu Pro 
65                  70                  75                  80  


Gly Thr Leu Cys Leu Arg Ile Phe Arg Trp Gly Pro Arg Arg Arg Arg 
                85                  90                  95      


Gln Gly Ser Arg Thr Leu Leu Ala Glu His His Ile Thr Asn Leu Gly 
            100                 105                 110         


Trp His Thr Leu Thr Leu Pro Ser Ser Gly Leu Arg Gly Glu Lys Ser 
        115                 120                 125             


Gly Val Leu Lys Leu Gln Leu Asp Cys Arg Pro Leu Glu Gly Asn Ser 
    130                 135                 140                 


Thr Val Thr Gly Gln Pro Arg Arg Leu Leu Asp Thr Ala Gly His Gln 
145                 150                 155                 160 


Gln Pro Phe Leu Glu Leu Lys Ile Arg Ala Asn Glu Pro Gly Ala Gly 
                165                 170                 175     


Arg Ala Arg Arg Arg Thr Pro Thr Cys Glu Pro Ala Thr Pro Leu Cys 
            180                 185                 190         


Cys Arg Arg Asp His Tyr Val Asp Phe Gln Glu Leu Gly Trp Arg Asp 
        195                 200                 205             


Trp Ile Leu Gln Pro Glu Gly Tyr Gln Leu Asn Tyr Cys Ser Gly Gln 
    210                 215                 220                 


Cys Pro Pro His Leu Ala Gly Ser Pro Gly Ile Ala Ala Ser Phe His 
225                 230                 235                 240 


Ser Ala Val Phe Ser Leu Leu Lys Ala Asn Asn Pro Trp Pro Ala Ser 
                245                 250                 255     


Thr Ser Cys Cys Val Pro Thr Ala Arg Arg Pro Leu Ser Leu Leu Tyr 
            260                 265                 270         


Leu Asp 
        


<210>  7184
<211>  350
<212>  PRT
<213>  Homo Sapiens

<400>  7184

Met Arg Leu Pro Asp Val Gln Leu Trp Leu Val Leu Leu Trp Ala Leu 
1               5                   10                  15      


Val Arg Ala Gln Gly Thr Gly Ser Val Cys Pro Ser Cys Gly Gly Ser 
            20                  25                  30          


Lys Leu Ala Pro Gln Ala Glu Arg Ala Leu Val Leu Glu Leu Ala Lys 
        35                  40                  45              


Gln Gln Ile Leu Asp Gly Leu His Leu Thr Ser Arg Pro Arg Ile Thr 
    50                  55                  60                  


His Pro Pro Pro Gln Ala Ala Leu Thr Arg Ala Leu Arg Arg Leu Gln 
65                  70                  75                  80  


Pro Gly Ser Val Ala Pro Gly Asn Gly Glu Glu Val Ile Ser Phe Ala 
                85                  90                  95      


Thr Val Thr Asp Ser Thr Ser Ala Tyr Ser Ser Leu Leu Thr Phe His 
            100                 105                 110         


Leu Ser Thr Pro Arg Ser His His Leu Tyr His Ala Arg Leu Trp Leu 
        115                 120                 125             


His Val Leu Pro Thr Leu Pro Gly Thr Leu Cys Leu Arg Ile Phe Arg 
    130                 135                 140                 


Trp Gly Pro Arg Arg Arg Arg Gln Gly Ser Arg Thr Leu Leu Ala Glu 
145                 150                 155                 160 


His His Ile Thr Asn Leu Gly Trp His Thr Leu Thr Leu Pro Ser Ser 
                165                 170                 175     


Gly Leu Arg Gly Glu Lys Ser Gly Val Leu Lys Leu Gln Leu Asp Cys 
            180                 185                 190         


Arg Pro Leu Glu Gly Asn Ser Thr Val Thr Gly Gln Pro Arg Arg Leu 
        195                 200                 205             


Leu Asp Thr Ala Gly His Gln Gln Pro Phe Leu Glu Leu Lys Ile Arg 
    210                 215                 220                 


Ala Asn Glu Pro Gly Ala Gly Arg Ala Arg Arg Arg Thr Pro Thr Cys 
225                 230                 235                 240 


Glu Pro Ala Thr Pro Leu Cys Cys Arg Arg Asp His Tyr Val Asp Phe 
                245                 250                 255     


Gln Glu Leu Gly Trp Arg Asp Trp Ile Leu Gln Pro Glu Gly Tyr Gln 
            260                 265                 270         


Leu Asn Tyr Cys Ser Gly Gln Cys Pro Pro His Leu Ala Gly Ser Pro 
        275                 280                 285             


Gly Ile Ala Ala Ser Phe His Ser Ala Val Phe Ser Leu Leu Lys Ala 
    290                 295                 300                 


Asn Asn Pro Trp Pro Ala Ser Thr Ser Cys Cys Val Pro Thr Ala Arg 
305                 310                 315                 320 


Arg Pro Leu Ser Leu Leu Tyr Leu Asp His Asn Gly Asn Val Val Lys 
                325                 330                 335     


Thr Asp Val Pro Asp Met Val Val Glu Ala Cys Gly Cys Ser 
            340                 345                 350 


<210>  7185
<211>  104
<212>  PRT
<213>  Homo Sapiens

<400>  7185

Leu Asp Ile Ser Phe Pro Pro Ser Tyr Pro Tyr Ser Glu Asp Ala Arg 
1               5                   10                  15      


Gln Gly Glu Gln Tyr Met Asn Thr Arg Cys Pro Ala Trp Cys Asp Arg 
            20                  25                  30          


Ile Leu Met Ser Pro Ser Ala Lys Glu Leu Val Leu Arg Ser Glu Ser 
        35                  40                  45              


Glu Glu Lys Val Val Thr Tyr Asp His Ile Gly Pro Asn Val Cys Met 
    50                  55                  60                  


Gly Asp His Lys Pro Val Phe Leu Ala Phe Arg Ile Met Pro Gly Ala 
65                  70                  75                  80  


Gly Lys Arg Cys Gln Arg His Glu Arg Thr Leu Arg Glu Pro Pro Cys 
                85                  90                  95      


Ser Arg Gly Pro Asn Thr His Ser 
            100                 


<210>  7186
<211>  412
<212>  PRT
<213>  Homo Sapiens

<400>  7186

Met Ala Gly Lys Ala Ala Ala Pro Gly Thr Ala Val Leu Leu Val Thr 
1               5                   10                  15      


Ala Asn Val Gly Ser Leu Phe Asp Asp Pro Glu Asn Leu Gln Lys Asn 
            20                  25                  30          


Trp Leu Arg Glu Phe Tyr Gln Val Val His Thr His Lys Pro His Phe 
        35                  40                  45              


Met Ala Leu His Cys Gln Glu Phe Gly Gly Lys Asn Tyr Glu Ala Ser 
    50                  55                  60                  


Met Ser His Val Asp Lys Phe Val Lys Glu Leu Leu Ser Ser Asp Ala 
65                  70                  75                  80  


Met Lys Glu Tyr Asn Arg Ala Arg Val Tyr Leu Asp Glu Asn Tyr Lys 
                85                  90                  95      


Ser Gln Glu His Phe Thr Ala Leu Gly Ser Phe Tyr Phe Leu His Glu 
            100                 105                 110         


Ser Leu Lys Asn Ile Tyr Gln Phe Asp Phe Lys Ala Lys Lys Tyr Arg 
        115                 120                 125             


Lys Val Ala Gly Lys Glu Ile Tyr Ser Asp Thr Leu Glu Ser Thr Pro 
    130                 135                 140                 


Met Leu Glu Lys Glu Lys Phe Pro Gln Asp Tyr Phe Pro Glu Cys Lys 
145                 150                 155                 160 


Trp Ser Arg Lys Gly Phe Ile Arg Thr Arg Trp Cys Ile Ala Asp Cys 
                165                 170                 175     


Ala Phe Asp Leu Val Asn Ile His Leu Phe His Asp Ala Ser Asn Leu 
            180                 185                 190         


Val Ala Trp Glu Thr Ser Pro Ser Val Tyr Ser Gly Ile Arg His Lys 
        195                 200                 205             


Ala Leu Gly Tyr Val Leu Asp Arg Ile Ile Asp Gln Arg Phe Glu Lys 
    210                 215                 220                 


Val Ser Tyr Phe Val Phe Gly Asp Phe Asn Phe Arg Leu Asp Ser Lys 
225                 230                 235                 240 


Ser Val Val Glu Thr Leu Cys Thr Lys Ala Thr Met Gln Thr Val Arg 
                245                 250                 255     


Ala Ala Asp Thr Asn Glu Val Val Lys Leu Ile Phe Arg Glu Ser Asp 
            260                 265                 270         


Asn Asp Arg Lys Val Met Leu Gln Leu Glu Lys Lys Leu Phe Asp Tyr 
        275                 280                 285             


Phe Asn Gln Glu Val Phe Arg Asp Asn Asn Gly Thr Ala Leu Leu Glu 
    290                 295                 300                 


Phe Asp Lys Glu Leu Ser Val Phe Lys Asp Arg Leu Tyr Glu Leu Asp 
305                 310                 315                 320 


Ile Ser Phe Pro Pro Ser Tyr Pro Tyr Ser Glu Asp Ala Arg Gln Gly 
                325                 330                 335     


Glu Gln Tyr Met Asn Thr Arg Cys Pro Ala Trp Cys Asp Arg Ile Leu 
            340                 345                 350         


Met Ser Pro Ser Ala Lys Glu Leu Val Leu Arg Ser Glu Ser Glu Glu 
        355                 360                 365             


Lys Val Val Thr Tyr Asp His Ile Gly Pro Asn Val Cys Met Gly Asp 
    370                 375                 380                 


His Lys Pro Val Phe Leu Ala Phe Arg Ile Met Pro Gly Ala Gly Lys 
385                 390                 395                 400 


Pro His Ala His Val His Lys Cys Cys Val Val Gln 
                405                 410         


<210>  7187
<211>  387
<212>  PRT
<213>  Homo Sapiens

<400>  7187

Met Ala Gly Lys Ala Ala Ala Pro Gly Thr Ala Val Leu Leu Val Thr 
1               5                   10                  15      


Ala Asn Val Gly Ser Leu Phe Asp Asp Pro Glu Asn Leu Gln Lys Asn 
            20                  25                  30          


Trp Leu Arg Glu Phe Tyr Gln Val Val His Thr His Lys Pro His Phe 
        35                  40                  45              


Met Ala Leu His Cys Gln Glu Phe Gly Gly Lys Asn Tyr Glu Ala Ser 
    50                  55                  60                  


Met Ser His Val Asp Lys Phe Val Lys Glu Leu Leu Ser Ser Asp Ala 
65                  70                  75                  80  


Met Lys Glu Tyr Asn Arg Ala Arg Val Tyr Leu Asp Glu Asn Tyr Lys 
                85                  90                  95      


Ser Gln Glu His Phe Thr Ala Leu Gly Ser Phe Tyr Phe Leu His Glu 
            100                 105                 110         


Ser Leu Lys Asn Ile Tyr Gln Phe Asp Phe Lys Ala Lys Lys Tyr Arg 
        115                 120                 125             


Lys Val Ala Gly Lys Glu Ile Tyr Ser Asp Thr Leu Glu Ser Thr Pro 
    130                 135                 140                 


Met Leu Glu Lys Glu Lys Phe Pro Gln Asp Tyr Phe Pro Glu Cys Lys 
145                 150                 155                 160 


Trp Ser Arg Lys Gly Phe Ile Arg Thr Arg Trp Cys Ile Ala Asp Cys 
                165                 170                 175     


Ala Phe Asp Leu Val Asn Ile His Leu Phe His Asp Ala Ser Asn Leu 
            180                 185                 190         


Val Ala Trp Glu Thr Ser Pro Ser Val Tyr Ser Gly Ile Arg His Lys 
        195                 200                 205             


Ala Leu Gly Tyr Val Leu Asp Arg Ile Ile Asp Gln Arg Phe Glu Lys 
    210                 215                 220                 


Val Ser Tyr Phe Val Phe Gly Asp Phe Asn Phe Arg Leu Asp Ser Lys 
225                 230                 235                 240 


Ser Val Val Glu Thr Leu Cys Thr Lys Ala Thr Met Gln Thr Val Arg 
                245                 250                 255     


Ala Ala Asp Thr Asn Glu Val Val Lys Leu Ile Phe Arg Glu Ser Asp 
            260                 265                 270         


Asn Asp Arg Lys Val Met Leu Gln Leu Glu Lys Lys Leu Phe Asp Tyr 
        275                 280                 285             


Phe Asn Gln Glu Val Phe Arg Asp Asn Asn Gly Thr Ala Leu Leu Glu 
    290                 295                 300                 


Phe Asp Lys Glu Leu Ser Val Phe Lys Asp Arg Leu Tyr Glu Leu Asp 
305                 310                 315                 320 


Ile Ser Phe Pro Pro Ser Tyr Pro Tyr Ser Glu Asp Ala Arg Gln Gly 
                325                 330                 335     


Glu Gln Tyr Met Asn Thr Arg Cys Pro Ala Trp Cys Asp Arg Ile Leu 
            340                 345                 350         


Met Ser Pro Ser Ala Lys Glu Leu Val Leu Arg Val Ser Val Cys Cys 
        355                 360                 365             


Pro Ser Pro Gly His Arg Gly Met Trp Ser Ala Gly Ser Gly Leu Ala 
    370                 375                 380                 


Gln Pro Trp 
385         


<210>  7188
<211>  138
<212>  PRT
<213>  Homo Sapiens

<400>  7188

Val Thr Ala Asn Val Gly Ser Leu Phe Asp Asp Pro Glu Asn Leu Gln 
1               5                   10                  15      


Lys Asn Trp Leu Arg Glu Phe Tyr Gln Ala Leu Gly Ser Phe Tyr Phe 
            20                  25                  30          


Leu His Glu Ser Leu Lys Asn Ile Tyr Gln Phe Asp Phe Lys Ala Lys 
        35                  40                  45              


Lys Tyr Arg Lys Val Ala Gly Lys Glu Ile Tyr Ser Asp Thr Leu Glu 
    50                  55                  60                  


Ser Thr Pro Met Leu Glu Lys Glu Lys Phe Pro Gln Asp Tyr Phe Pro 
65                  70                  75                  80  


Glu Cys Lys Trp Ser Arg Lys Gly Phe Ile Arg Thr Arg Trp Cys Ile 
                85                  90                  95      


Ala Asp Cys Ala Phe Asp Leu Val Asn Ile His Leu Phe His Asp Ala 
            100                 105                 110         


Ser Asn Leu Val Ala Trp Glu Thr Ser Pro Ser Val Tyr Ser Gly Ile 
        115                 120                 125             


Arg His Lys Ala Leu Gly Tyr Val Leu Asp 
    130                 135             


<210>  7189
<211>  278
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7189

Xaa Gln Lys Asn Trp Leu Arg Glu Phe Tyr Gln Val Val His Thr His 
1               5                   10                  15      


Lys Pro His Phe Met Ala Leu His Cys Gln Glu Phe Gly Gly Lys Asn 
            20                  25                  30          


Tyr Glu Ala Ser Met Ser His Val Asp Lys Phe Val Lys Glu Leu Leu 
        35                  40                  45              


Ser Ser Asp Ala Met Lys Glu Tyr Asn Arg Ala Arg Val Tyr Leu Asp 
    50                  55                  60                  


Glu Asn Tyr Lys Ser Gln Glu His Phe Thr Ala Leu Gly Ser Phe Tyr 
65                  70                  75                  80  


Phe Leu His Glu Ser Leu Lys Asn Ile Tyr Gln Phe Asp Phe Lys Ala 
                85                  90                  95      


Lys Lys Tyr Arg Lys Val Ala Gly Lys Glu Ile Tyr Ser Asp Thr Leu 
            100                 105                 110         


Glu Ser Thr Pro Met Leu Glu Lys Glu Lys Phe Pro Gln Asp Tyr Phe 
        115                 120                 125             


Pro Glu Cys Lys Trp Ser Arg Lys Gly Phe Ile Arg Thr Arg Trp Cys 
    130                 135                 140                 


Ile Ala Asp Cys Ala Phe Asp Leu Val Asn Ile His Leu Phe His Asp 
145                 150                 155                 160 


Ala Ser Asn Leu Val Ala Trp Glu Thr Ser Pro Ser Val Tyr Ser Gly 
                165                 170                 175     


Ile Arg His Lys Ala Leu Gly Tyr Val Leu Asp Arg Ile Ile Asp Gln 
            180                 185                 190         


Arg Phe Glu Lys Val Ser Tyr Phe Val Phe Gly Asp Phe Asn Phe Arg 
        195                 200                 205             


Leu Asp Ser Lys Ser Val Val Glu Leu Leu Glu Phe Asp Lys Glu Leu 
    210                 215                 220                 


Ser Val Phe Lys Asp Arg Leu Tyr Glu Leu Asp Ile Ser Phe Pro Pro 
225                 230                 235                 240 


Ser Tyr Pro Tyr Ser Glu Asp Ala Arg Gln Gly Glu Gln Tyr Met Asn 
                245                 250                 255     


Thr Arg Cys Pro Ala Trp Cys Asp Arg Ile Leu Met Ser Pro Ser Ala 
            260                 265                 270         


Lys Glu Leu Val Leu Arg 
        275             


<210>  7190
<211>  92
<212>  PRT
<213>  Homo Sapiens

<400>  7190

Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Gly Pro Asp Pro Ala Ala Ala Phe Val Asn Gln His Leu Cys Gly 
            20                  25                  30          


Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
        35                  40                  45              


Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Ala Gly 
    50                  55                  60                  


Glu Leu Leu Gln Leu Asp Ala Ala Arg Arg Gln Pro His Thr Arg Arg 
65                  70                  75                  80  


Leu Leu His Arg Glu Arg Trp Asn Lys Ala Leu Glu 
                85                  90          


<210>  7191
<211>  98
<212>  PRT
<213>  Homo Sapiens

<400>  7191

Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Gly Pro Asp Pro Ala Ala Ala Phe Val Asn Gln His Leu Cys Gly 
            20                  25                  30          


Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
        35                  40                  45              


Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Gly Ser 
    50                  55                  60                  


Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly Ile Val 
65                  70                  75                  80  


Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr 
                85                  90                  95      


Cys Asn 
        


<210>  7192
<211>  110
<212>  PRT
<213>  Homo Sapiens

<400>  7192

Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Gly Pro Asp Pro Ala Ala Ala Phe Val Asn Gln His Leu Cys Gly 
            20                  25                  30          


Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
        35                  40                  45              


Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly 
    50                  55                  60                  


Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu 
65                  70                  75                  80  


Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys 
                85                  90                  95      


Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
            100                 105                 110 


<210>  7193
<211>  110
<212>  PRT
<213>  Homo Sapiens

<400>  7193

Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Gly Pro Asp Pro Ala Ala Ala Phe Val Asn Gln His Leu Cys Gly 
            20                  25                  30          


Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
        35                  40                  45              


Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly 
    50                  55                  60                  


Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu 
65                  70                  75                  80  


Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys 
                85                  90                  95      


Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
            100                 105                 110 


<210>  7194
<211>  110
<212>  PRT
<213>  Homo Sapiens

<400>  7194

Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Gly Pro Asp Pro Ala Ala Ala Phe Val Asn Gln His Leu Cys Gly 
            20                  25                  30          


Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
        35                  40                  45              


Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly 
    50                  55                  60                  


Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu 
65                  70                  75                  80  


Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys 
                85                  90                  95      


Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
            100                 105                 110 


<210>  7195
<211>  200
<212>  PRT
<213>  Homo Sapiens

<400>  7195

Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Gly Pro Asp Pro Ala Ala Ala Phe Val Asn Gln His Leu Cys Gly 
            20                  25                  30          


Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
        35                  40                  45              


Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Ala Ser 
    50                  55                  60                  


Ala Leu Ser Leu Ser Ser Ser Thr Ser Thr Trp Pro Glu Gly Leu Asp 
65                  70                  75                  80  


Ala Thr Ala Arg Ala Pro Pro Ala Leu Val Val Thr Ala Asn Ile Gly 
                85                  90                  95      


Gln Ala Gly Gly Ser Ser Ser Arg Gln Phe Arg Gln Arg Ala Leu Gly 
            100                 105                 110         


Thr Ser Asp Ser Pro Val Leu Phe Ile His Cys Pro Gly Ala Ala Gly 
        115                 120                 125             


Thr Ala Gln Gly Leu Glu Tyr Arg Gly Arg Arg Val Thr Thr Glu Leu 
    130                 135                 140                 


Val Trp Glu Glu Val Asp Ser Ser Pro Gln Pro Gln Gly Ser Glu Ser 
145                 150                 155                 160 


Leu Pro Ala Gln Pro Pro Ala Gln Pro Ala Pro Gln Pro Glu Pro Gln 
                165                 170                 175     


Gln Ala Arg Glu Pro Ser Pro Glu Val Ser Cys Cys Gly Leu Trp Pro 
            180                 185                 190         


Arg Arg Pro Gln Arg Ser Gln Asn 
        195                 200 


<210>  7196
<211>  200
<212>  PRT
<213>  Homo Sapiens

<400>  7196

Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Gly Pro Asp Pro Ala Ala Ala Phe Val Asn Gln His Leu Cys Gly 
            20                  25                  30          


Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
        35                  40                  45              


Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Ala Ser 
    50                  55                  60                  


Ala Leu Ser Leu Ser Ser Ser Thr Ser Thr Trp Pro Glu Gly Leu Asp 
65                  70                  75                  80  


Ala Thr Ala Arg Ala Pro Pro Ala Leu Val Val Thr Ala Asn Ile Gly 
                85                  90                  95      


Gln Ala Gly Gly Ser Ser Ser Arg Gln Phe Arg Gln Arg Ala Leu Gly 
            100                 105                 110         


Thr Ser Asp Ser Pro Val Leu Phe Ile His Cys Pro Gly Ala Ala Gly 
        115                 120                 125             


Thr Ala Gln Gly Leu Glu Tyr Arg Gly Arg Arg Val Thr Thr Glu Leu 
    130                 135                 140                 


Val Trp Glu Glu Val Asp Ser Ser Pro Gln Pro Gln Gly Ser Glu Ser 
145                 150                 155                 160 


Leu Pro Ala Gln Pro Pro Ala Gln Pro Ala Pro Gln Pro Glu Pro Gln 
                165                 170                 175     


Gln Ala Arg Glu Pro Ser Pro Glu Val Ser Cys Cys Gly Leu Trp Pro 
            180                 185                 190         


Arg Arg Pro Gln Arg Ser Gln Asn 
        195                 200 


<210>  7197
<211>  157
<212>  PRT
<213>  Homo Sapiens

<400>  7197

Met Asp Pro Arg Leu Pro Ala Trp Ala Leu Val Leu Leu Gly Pro Ala 
1               5                   10                  15      


Leu Val Phe Ala Leu Gly Pro Ala Pro Thr Pro Glu Met Arg Glu Lys 
            20                  25                  30          


Leu Cys Gly His His Phe Val Arg Ala Leu Val Arg Val Cys Gly Gly 
        35                  40                  45              


Pro Arg Trp Ser Thr Glu Ala Arg Arg Pro Ala Thr Gly Gly Asp Gln 
    50                  55                  60                  


Arg Glu Ser His Ser Val Ser Gln Ala Gly Leu Lys Leu Leu Ser Ser 
65                  70                  75                  80  


Ser Asn Pro Pro Thr Leu Thr Phe Gln Ser Val Gly Ile Ser Asp Val 
                85                  90                  95      


Ser Cys Tyr Ser Gly Trp Arg Asp Asp Ile Cys Ser Met Gly Trp Trp 
            100                 105                 110         


Pro Thr Val Ile Ser Arg Trp Asp Leu Ala Cys Ser Pro Cys Pro Arg 
        115                 120                 125             


Pro Leu Thr Ile Thr Ala Thr Thr Val Gln Leu Pro Pro Thr Leu His 
    130                 135                 140                 


Ala Thr Ala Ala Ser Val Ala Val Pro Asn Lys Thr Cys 
145                 150                 155         


<210>  7198
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  7198

Met Asp Pro Arg Leu Pro Ala Trp Ala Leu Val Leu Leu Gly Pro Ala 
1               5                   10                  15      


Leu Val Phe Ala Leu Gly Pro Ala Pro Thr Pro Glu Met Arg Glu Lys 
            20                  25                  30          


Leu Cys Gly His His Phe Val Arg Ala Leu Val Arg Val Cys Gly Gly 
        35                  40                  45              


Pro Arg Trp Ser Thr Glu Ala Arg Arg Pro Ala Thr Gly Gly Asp Arg 
    50                  55                  60                  


Glu Leu Leu Gln Trp Leu Glu Arg Arg His Leu Leu His Gly Leu Val 
65                  70                  75                  80  


Ala Asp Ser Asn Leu Thr Leu Gly Pro Gly Leu Gln Pro Leu Pro Gln 
                85                  90                  95      


Thr Ser His His His Arg His His Arg Ala Ala Ala Thr Asn Pro Ala 
            100                 105                 110         


Arg Tyr Cys Cys Leu Ser Gly Cys Thr Gln Gln Asp Leu Leu Thr Leu 
        115                 120                 125             


Cys Pro Tyr 
    130     


<210>  7199
<211>  71
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7199

Xaa Asp Pro Arg Leu Pro Ala Trp Ala Leu Val Leu Leu Gly Pro Ala 
1               5                   10                  15      


Leu Val Phe Ala Leu Gly Pro Ala Pro Thr Pro Glu Met Arg Glu Lys 
            20                  25                  30          


Leu Cys Gly His His Phe Val Arg Ala Leu Val Arg Val Cys Gly Gly 
        35                  40                  45              


Pro Arg Trp Ser Thr Glu Ala Arg Arg Pro Ala Thr Gly Gly Asp Pro 
    50                  55                  60                  


Glu Phe His Ser Val Pro Arg 
65                  70      


<210>  7200
<211>  139
<212>  PRT
<213>  Homo Sapiens

<400>  7200

Met Ala Ser Leu Phe Arg Ser Tyr Leu Pro Ala Ile Trp Leu Leu Leu 
1               5                   10                  15      


Ser Gln Leu Leu Arg Glu Ser Leu Ala Ala Glu Leu Arg Gly Cys Gly 
            20                  25                  30          


Pro Arg Phe Gly Lys His Leu Leu Ser Tyr Cys Pro Met Pro Glu Lys 
        35                  40                  45              


Thr Phe Thr Thr Thr Pro Gly Gly Trp Leu Leu Glu Ser Gly Arg Pro 
    50                  55                  60                  


Lys Glu Met Val Ser Thr Ser Asn Asn Lys Asp Gly Gln Ala Leu Gly 
65                  70                  75                  80  


Thr Thr Ser Glu Phe Ile Pro Asn Leu Ser Pro Glu Leu Lys Lys Pro 
                85                  90                  95      


Leu Ser Glu Gly Gln Pro Ser Leu Lys Lys Ile Ile Leu Ser Arg Lys 
            100                 105                 110         


Lys Arg Ser Gly Arg His Arg Phe Asp Pro Phe Cys Cys Glu Val Ile 
        115                 120                 125             


Cys Asp Asp Gly Thr Ser Val Lys Leu Cys Thr 
    130                 135                 


<210>  7201
<211>  135
<212>  PRT
<213>  Homo Sapiens

<400>  7201

Met Lys Gly Ser Ile Phe Thr Leu Phe Leu Phe Ser Val Leu Phe Ala 
1               5                   10                  15      


Ile Ser Glu Val Arg Ser Lys Glu Ser Val Arg Leu Cys Gly Leu Glu 
            20                  25                  30          


Tyr Ile Arg Thr Val Ile Tyr Ile Cys Ala Ser Ser Arg Trp Arg Arg 
        35                  40                  45              


His Gln Glu Gly Ile Pro Gln Ala Gln Gln Ala Glu Thr Gly Asn Ser 
    50                  55                  60                  


Phe Gln Leu Pro His Lys Arg Glu Phe Ser Glu Glu Asn Pro Ala Gln 
65                  70                  75                  80  


Asn Leu Pro Lys Val Asp Ala Ser Gly Glu Asp Arg Leu Trp Gly Gly 
                85                  90                  95      


Gln Met Pro Thr Glu Glu Leu Trp Lys Ser Lys Lys His Ser Val Met 
            100                 105                 110         


Ser Arg Gln Asp Leu Gln Thr Leu Cys Cys Thr Asp Gly Cys Ser Met 
        115                 120                 125             


Thr Asp Leu Ser Ala Leu Cys 
    130                 135 


<210>  7202
<211>  213
<212>  PRT
<213>  Homo Sapiens

<400>  7202

Met Pro Arg Leu Leu Arg Leu Ser Leu Leu Trp Leu Gly Leu Leu Leu 
1               5                   10                  15      


Val Arg Phe Ser Arg Glu Leu Ser Asp Ile Ser Ser Ala Arg Lys Leu 
            20                  25                  30          


Cys Gly Arg Tyr Leu Val Lys Glu Ile Glu Lys Leu Cys Gly His Ala 
        35                  40                  45              


Asn Trp Ser Gln Phe Arg Phe Glu Glu Glu Thr Pro Phe Ser Arg Leu 
    50                  55                  60                  


Ile Ala Gln Ala Ser Glu Lys Val Glu Ala Tyr Ser Pro Tyr Gln Phe 
65                  70                  75                  80  


Glu Ser Pro Gln Thr Ala Ser Pro Ala Arg Gly Arg Gly Thr Asn Pro 
                85                  90                  95      


Val Ser Thr Ser Trp Glu Glu Ala Val Asn Ser Trp Glu Met Gln Ser 
            100                 105                 110         


Leu Pro Glu Tyr Lys Asp Lys Lys Gly Tyr Ser Pro Leu Gly Lys Thr 
        115                 120                 125             


Arg Glu Phe Ser Ser Ser His Asn Ile Asn Val Tyr Ile His Glu Asn 
    130                 135                 140                 


Ala Lys Phe Gln Lys Lys Arg Arg Asn Lys Ile Lys Thr Leu Ser Asn 
145                 150                 155                 160 


Leu Phe Trp Gly His His Pro Gln Arg Lys Arg Arg Gly Tyr Ser Glu 
                165                 170                 175     


Lys Cys Cys Leu Thr Gly Cys Thr Lys Glu Glu Leu Ser Ile Ala Cys 
            180                 185                 190         


Leu Pro Tyr Ile Asp Phe Lys Arg Leu Lys Glu Lys Arg Ser Ser Leu 
        195                 200                 205             


Val Thr Lys Ile Tyr 
    210             


<210>  7203
<211>  902
<212>  PRT
<213>  Homo Sapiens

<400>  7203

Met Ala Val Tyr Thr Tyr Leu Arg Leu Ile Val Asp His His Gly Thr 
1               5                   10                  15      


Ala Gln Leu Gln Ala Leu Arg Gln Lys Glu Val Asp Phe Cys Ile Ser 
            20                  25                  30          


Leu Leu Arg Glu Arg Phe Met Glu Cys Leu Met Ile Gly Arg Asp Leu 
        35                  40                  45              


Val Arg Leu Leu Gln Asn Val Ala Arg Ile Pro Glu Phe Glu Leu Leu 
    50                  55                  60                  


Trp Lys Asp Ile Ile His Asn Pro Gln Ala Leu Ser Pro Gln Phe Thr 
65                  70                  75                  80  


Gly Ile Leu Gln Leu Leu Gln Ser Arg Thr Ser Arg Lys Phe Leu Ala 
                85                  90                  95      


Cys Arg Leu Thr Pro Asp Met Glu Thr Lys Leu Leu Phe Met Thr Ser 
            100                 105                 110         


Arg Val Arg Phe Gly Gln Gln Lys Arg Tyr Gln Asp Trp Phe Gln Arg 
        115                 120                 125             


Gln Tyr Leu Ser Thr Pro Asp Ser Gln Ser Leu Arg Cys Asp Leu Ile 
    130                 135                 140                 


Arg Tyr Ile Cys Gly Val Val His Pro Ser Asn Glu Val Leu Ser Ser 
145                 150                 155                 160 


Asp Ile Leu Pro Arg Trp Ala Ile Ile Gly Trp Leu Leu Thr Thr Cys 
                165                 170                 175     


Thr Ser Asn Val Ala Ala Ser Asn Ala Lys Leu Ala Leu Phe Tyr Asp 
            180                 185                 190         


Trp Leu Phe Phe Ser Pro Asp Lys Asp Ser Ile Met Asn Ile Glu Pro 
        195                 200                 205             


Ala Ile Leu Val Met His His Ser Met Lys Pro His Pro Ala Ile Thr 
    210                 215                 220                 


Ala Thr Leu Leu Asp Phe Met Cys Arg Ile Ile Pro Asn Phe Tyr Pro 
225                 230                 235                 240 


Pro Leu Glu Gly His Val Arg Gln Gly Val Phe Ser Ser Leu Asn His 
                245                 250                 255     


Ile Val Glu Lys Arg Val Leu Ala His Leu Ala Pro Leu Phe Asp Asn 
            260                 265                 270         


Pro Lys Leu Asp Lys Glu Leu Arg Ala Met Leu Arg Glu Lys Phe Pro 
        275                 280                 285             


Glu Phe Cys Ser Ser Pro Ser Pro Pro Val Glu Val Lys Ile Glu Glu 
    290                 295                 300                 


Pro Val Ser Met Glu Met Asp Asn His Met Ser Asp Lys Asp Glu Ser 
305                 310                 315                 320 


Cys Tyr Asp Asn Ala Glu Ala Ala Phe Ser Asp Asp Glu Glu Asp Leu 
                325                 330                 335     


Asn Ser Lys Gly Lys Lys Arg Glu Phe Arg Phe His Pro Ile Lys Glu 
            340                 345                 350         


Thr Val Val Glu Glu Pro Val Asp Ile Thr Pro Tyr Leu Asp Gln Leu 
        355                 360                 365             


Asp Glu Ser Leu Arg Asp Lys Val Leu Gln Leu Gln Lys Gly Ser Asp 
    370                 375                 380                 


Thr Glu Ala Gln Cys Glu Val Met Gln Glu Ile Val Asp Gln Val Leu 
385                 390                 395                 400 


Glu Glu Asp Phe Asp Ser Glu Gln Leu Ser Val Leu Ala Ser Cys Leu 
                405                 410                 415     


Gln Glu Leu Phe Lys Ala His Phe Arg Gly Glu Val Leu Pro Glu Glu 
            420                 425                 430         


Ile Thr Glu Glu Ser Leu Glu Glu Ser Val Gly Lys Pro Leu Tyr Leu 
        435                 440                 445             


Ile Phe Arg Asn Leu Cys Gln Met Gln Glu Asp Asn Ser Ser Phe Ser 
    450                 455                 460                 


Leu Leu Leu Asp Leu Leu Ser Glu Leu Tyr Gln Lys Gln Pro Lys Ile 
465                 470                 475                 480 


Gly Tyr His Leu Leu Tyr Tyr Leu Arg Ala Ser Lys Ala Ala Ala Gly 
                485                 490                 495     


Lys Met Asn Leu Tyr Glu Ser Phe Ala Gln Ala Thr Gln Leu Gly Asp 
            500                 505                 510         


Leu His Thr Cys Leu Met Met Asp Met Lys Ala Cys Gln Glu Asp Asp 
        515                 520                 525             


Val Arg Leu Leu Cys His Leu Thr Pro Ser Ile Tyr Thr Glu Phe Pro 
    530                 535                 540                 


Asp Glu Thr Leu Arg Ser Gly Glu Leu Leu Asn Met Ile Val Ala Val 
545                 550                 555                 560 


Ile Asp Ser Ala Gln Leu Gln Glu Leu Val Cys His Val Met Met Gly 
                565                 570                 575     


Asn Leu Val Met Phe Arg Lys Asp Ser Val Leu Asn Ile Leu Ile Gln 
            580                 585                 590         


Ser Leu Asp Trp Glu Thr Phe Glu Gln Tyr Cys Ala Trp Gln Leu Phe 
        595                 600                 605             


Leu Ala His Asn Ile Pro Leu Glu Thr Ile Ile Pro Ile Leu Gln His 
    610                 615                 620                 


Leu Lys Tyr Lys Glu His Pro Glu Ala Leu Ser Cys Leu Leu Leu Gln 
625                 630                 635                 640 


Leu Arg Arg Glu Lys Pro Ser Glu Glu Met Val Lys Met Val Leu Ser 
                645                 650                 655     


Arg Pro Cys His Pro Asp Asp Gln Phe Thr Thr Ser Ile Leu Arg His 
            660                 665                 670         


Trp Cys Met Lys His Asp Glu Leu Leu Ala Glu His Ile Lys Ser Leu 
        675                 680                 685             


Leu Ile Lys Asn Asn Ser Leu Pro Arg Lys Arg Gln Ser Leu Arg Ser 
    690                 695                 700                 


Ser Ser Ser Lys Leu Ala Gln Leu Thr Leu Glu Gln Ile Leu Glu His 
705                 710                 715                 720 


Leu Asp Asn Leu Arg Leu Asn Leu Thr Asn Thr Lys Gln Asn Cys Met 
                725                 730                 735     


Pro Ser Thr Leu Gly Val Gln Cys Arg Arg Cys Cys Pro Gly Pro Asp 
            740                 745                 750         


Tyr Ala Trp Ser Gln Ala Gly Gly Arg Gly Arg Thr Pro Gly Ala Thr 
        755                 760                 765             


Thr His Thr Arg Asp Lys Thr Thr Cys Ala Cys Cys Leu Ile Ser Ser 
    770                 775                 780                 


Gln Thr Ser Asp Cys Phe Ser Phe Pro Ala Leu Pro Phe Leu Pro Leu 
785                 790                 795                 800 


Val Phe Ser Gln Thr Pro Ile Leu Gln Ala Leu Gln His Val Gln Ala 
                805                 810                 815     


Ser Cys Asp Glu Ala His Lys Met Lys Phe Ser Asp Leu Phe Ser Leu 
            820                 825                 830         


Ala Glu Glu Tyr Glu Asp Ser Ser Thr Lys Pro Pro Lys Ser Arg Arg 
        835                 840                 845             


Lys Ala Ala Leu Ser Ser Pro Arg Ser Arg Lys Asn Ala Thr Gln Pro 
    850                 855                 860                 


Pro Asn Ala Glu Glu Glu Ser Gly Ser Ser Ser Ala Ser Glu Glu Glu 
865                 870                 875                 880 


Asp Thr Lys Pro Lys Pro Thr Lys Arg Lys Arg Lys Gly Ser Ser Ala 
                885                 890                 895     


Val Gly Ser Asp Ser Asp 
            900         


<210>  7204
<211>  1042
<212>  PRT
<213>  Homo Sapiens

<400>  7204

Met Glu Leu Gln Lys Gly Lys Gly Ala Ala Ala Ala Ala Ala Ala Ser 
1               5                   10                  15      


Gly Ala Ala Gly Gly Gly Gly Gly Gly Ala Gly Ala Gly Ala Pro Gly 
            20                  25                  30          


Gly Gly Arg Leu Leu Leu Ser Thr Ser Leu Asp Ala Lys Asp Glu Leu 
        35                  40                  45              


Glu Glu Arg Leu Glu Arg Cys Met Ser Ile Val Thr Ser Met Thr Ala 
    50                  55                  60                  


Gly Val Ser Glu Arg Glu Ala Asn Asp Ala Leu Asn Ala Tyr Val Cys 
65                  70                  75                  80  


Lys Gly Leu Pro Gln His Glu Glu Ile Cys Leu Gly Leu Phe Thr Leu 
                85                  90                  95      


Ile Leu Thr Glu Pro Ala Gln Ala Gln Lys Cys Tyr Arg Asp Leu Ala 
            100                 105                 110         


Leu Val Ser Arg Asp Gly Met Asn Ile Val Leu Asn Lys Ile Asn Gln 
        115                 120                 125             


Ile Leu Met Glu Lys Tyr Leu Lys Leu Gln Asp Thr Cys Arg Thr Gln 
    130                 135                 140                 


Leu Val Trp Leu Val Arg Glu Leu Val Lys Ser Gly Val Leu Gly Ala 
145                 150                 155                 160 


Asp Gly Val Cys Met Thr Phe Met Lys Gln Ile Ala Gly Gly Asp Val 
                165                 170                 175     


Thr Ala Lys Asn Ile Trp Leu Ala Glu Ser Val Leu Asp Ile Leu Thr 
            180                 185                 190         


Glu Gln Arg Glu Trp Val Leu Lys Ser Ser Ile Leu Ile Ala Met Ala 
        195                 200                 205             


Val Tyr Thr Tyr Leu Arg Leu Ile Val Asp His His Gly Thr Ala Gln 
    210                 215                 220                 


Leu Gln Ala Leu Arg Gln Lys Glu Val Asp Phe Cys Ile Ser Leu Leu 
225                 230                 235                 240 


Arg Glu Arg Phe Met Glu Cys Leu Met Ile Gly Arg Asp Leu Val Arg 
                245                 250                 255     


Leu Leu Gln Asn Val Ala Arg Ile Pro Glu Phe Glu Leu Leu Trp Lys 
            260                 265                 270         


Asp Ile Ile His Asn Pro Gln Ala Leu Ser Pro Gln Phe Thr Gly Ile 
        275                 280                 285             


Leu Gln Leu Leu Gln Ser Arg Thr Ser Arg Lys Phe Leu Ala Cys Arg 
    290                 295                 300                 


Leu Thr Pro Asp Met Glu Thr Lys Leu Leu Phe Met Thr Ser Arg Val 
305                 310                 315                 320 


Arg Phe Gly Gln Gln Lys Arg Tyr Gln Asp Trp Phe Gln Arg Gln Tyr 
                325                 330                 335     


Leu Ser Thr Pro Asp Ser Gln Ser Leu Arg Cys Asp Leu Ile Arg Tyr 
            340                 345                 350         


Ile Cys Gly Val Val His Pro Ser Asn Glu Val Leu Ser Ser Asp Ile 
        355                 360                 365             


Leu Pro Arg Trp Ala Ile Ile Gly Trp Leu Leu Thr Thr Cys Thr Ser 
    370                 375                 380                 


Asn Val Ala Ala Ser Asn Ala Lys Leu Ala Leu Phe Tyr Asp Trp Leu 
385                 390                 395                 400 


Phe Phe Ser Pro Asp Lys Asp Ser Ile Met Asn Ile Glu Pro Ala Ile 
                405                 410                 415     


Leu Val Met His His Ser Met Lys Pro His Pro Ala Ile Thr Ala Thr 
            420                 425                 430         


Leu Leu Asp Phe Met Cys Arg Ile Ile Pro Asn Phe Tyr Pro Pro Leu 
        435                 440                 445             


Glu Gly His Val Arg Gln Gly Val Phe Ser Ser Leu Asn His Ile Val 
    450                 455                 460                 


Glu Lys Arg Val Leu Ala His Leu Ala Pro Leu Phe Asp Asn Pro Lys 
465                 470                 475                 480 


Leu Asp Lys Glu Leu Arg Ala Met Leu Arg Glu Lys Phe Pro Glu Phe 
                485                 490                 495     


Cys Ser Ser Pro Ser Pro Pro Val Glu Val Lys Ile Glu Glu Pro Val 
            500                 505                 510         


Ser Met Glu Met Asp Asn His Met Ser Asp Lys Asp Glu Ser Cys Tyr 
        515                 520                 525             


Asp Asn Ala Glu Ala Ala Phe Ser Asp Asp Glu Glu Asp Leu Asn Ser 
    530                 535                 540                 


Lys Gly Lys Lys Arg Glu Phe Arg Phe His Pro Ile Lys Glu Thr Val 
545                 550                 555                 560 


Val Glu Glu Pro Val Asp Ile Thr Pro Tyr Leu Asp Gln Leu Asp Glu 
                565                 570                 575     


Ser Leu Arg Asp Lys Val Leu Gln Leu Gln Lys Gly Ser Asp Thr Glu 
            580                 585                 590         


Ala Gln Cys Glu Val Met Gln Glu Ile Val Asp Gln Val Leu Glu Glu 
        595                 600                 605             


Asp Phe Asp Ser Glu Gln Leu Ser Val Leu Ala Ser Cys Leu Gln Glu 
    610                 615                 620                 


Leu Phe Lys Ala His Phe Arg Gly Glu Val Leu Pro Glu Glu Ile Thr 
625                 630                 635                 640 


Glu Glu Ser Leu Glu Glu Ser Val Gly Lys Pro Leu Tyr Leu Ile Phe 
                645                 650                 655     


Arg Asn Leu Cys Gln Met Gln Glu Asp Asn Ser Ser Phe Ser Leu Leu 
            660                 665                 670         


Leu Asp Leu Leu Ser Glu Leu Tyr Gln Lys Gln Pro Lys Ile Gly Tyr 
        675                 680                 685             


His Leu Leu Tyr Tyr Leu Arg Ala Ser Lys Ala Ala Ala Gly Lys Met 
    690                 695                 700                 


Asn Leu Tyr Glu Ser Phe Ala Gln Ala Thr Gln Leu Gly Asp Leu His 
705                 710                 715                 720 


Thr Cys Leu Met Met Asp Met Lys Ala Cys Gln Glu Asp Asp Val Arg 
                725                 730                 735     


Leu Leu Cys His Leu Thr Pro Ser Ile Tyr Thr Glu Phe Pro Asp Glu 
            740                 745                 750         


Thr Leu Arg Ser Gly Glu Leu Leu Asn Met Ile Val Ala Val Ile Asp 
        755                 760                 765             


Ser Ala Gln Leu Gln Glu Leu Val Cys His Val Met Met Gly Asn Leu 
    770                 775                 780                 


Val Met Phe Arg Lys Asp Ser Val Leu Asn Ile Leu Ile Gln Ser Leu 
785                 790                 795                 800 


Asp Trp Glu Thr Phe Glu Gln Tyr Cys Ala Trp Gln Leu Phe Leu Ala 
                805                 810                 815     


His Asn Ile Pro Leu Glu Thr Ile Ile Pro Ile Leu Gln His Leu Lys 
            820                 825                 830         


Tyr Lys Glu His Pro Glu Ala Leu Ser Cys Leu Leu Leu Gln Leu Arg 
        835                 840                 845             


Arg Glu Lys Pro Ser Glu Glu Met Val Lys Met Val Leu Ser Arg Pro 
    850                 855                 860                 


Cys His Pro Asp Asp Gln Phe Thr Thr Ser Ile Leu Arg His Trp Cys 
865                 870                 875                 880 


Met Lys His Asp Glu Leu Leu Ala Glu His Ile Lys Ser Leu Leu Ile 
                885                 890                 895     


Lys Asn Asn Ser Leu Pro Arg Lys Arg Gln Ser Leu Arg Ser Ser Ser 
            900                 905                 910         


Ser Lys Leu Ala Gln Leu Thr Leu Glu Gln Ile Leu Glu His Leu Asp 
        915                 920                 925             


Asn Leu Arg Leu Asn Leu Thr Asn Thr Lys Gln Asn Phe Phe Ser Gln 
    930                 935                 940                 


Thr Pro Ile Leu Gln Ala Leu Gln His Val Gln Ala Ser Cys Asp Glu 
945                 950                 955                 960 


Ala His Lys Met Lys Phe Ser Asp Leu Phe Ser Leu Ala Glu Glu Tyr 
                965                 970                 975     


Glu Asp Ser Ser Thr Lys Pro Pro Lys Ser Arg Arg Lys Ala Ala Leu 
            980                 985                 990         


Ser Ser Pro Arg Ser Arg Lys Asn  Ala Thr Gln Pro Pro  Asn Ala Glu 
        995                 1000                 1005             


Glu Glu  Ser Gly Ser Ser Ser  Ala Ser Glu Glu Glu  Asp Thr Lys 
    1010                 1015                 1020             


Pro Lys  Pro Thr Lys Arg Lys  Arg Lys Gly Ser Ser  Ala Val Gly 
    1025                 1030                 1035             


Ser Asp  Ser Asp 
    1040         


<210>  7205
<211>  1042
<212>  PRT
<213>  Homo Sapiens

<400>  7205

Met Glu Leu Gln Lys Gly Lys Gly Ala Ala Ala Ala Ala Ala Ala Ser 
1               5                   10                  15      


Gly Ala Ala Gly Gly Gly Gly Gly Gly Ala Gly Ala Gly Ala Pro Gly 
            20                  25                  30          


Gly Gly Arg Leu Leu Leu Ser Thr Ser Leu Asp Ala Lys Asp Glu Leu 
        35                  40                  45              


Glu Glu Arg Leu Glu Arg Cys Met Ser Ile Val Thr Ser Met Thr Ala 
    50                  55                  60                  


Gly Val Ser Glu Arg Glu Ala Asn Asp Ala Leu Asn Ala Tyr Val Cys 
65                  70                  75                  80  


Lys Gly Leu Pro Gln His Glu Glu Ile Cys Leu Gly Leu Phe Thr Leu 
                85                  90                  95      


Ile Leu Thr Glu Pro Ala Gln Ala Gln Lys Cys Tyr Arg Asp Leu Ala 
            100                 105                 110         


Leu Val Ser Arg Asp Gly Met Asn Ile Val Leu Asn Lys Ile Asn Gln 
        115                 120                 125             


Ile Leu Met Glu Lys Tyr Leu Lys Leu Gln Asp Thr Cys Arg Thr Gln 
    130                 135                 140                 


Leu Val Trp Leu Val Arg Glu Leu Val Lys Ser Gly Val Leu Gly Ala 
145                 150                 155                 160 


Asp Gly Val Cys Met Thr Phe Met Lys Gln Ile Ala Gly Gly Asp Val 
                165                 170                 175     


Thr Ala Lys Asn Ile Trp Leu Ala Glu Ser Val Leu Asp Ile Leu Thr 
            180                 185                 190         


Glu Gln Arg Glu Trp Val Leu Lys Ser Ser Ile Leu Ile Ala Met Ala 
        195                 200                 205             


Val Tyr Thr Tyr Leu Arg Leu Ile Val Asp His His Gly Thr Ala Gln 
    210                 215                 220                 


Leu Gln Ala Leu Arg Gln Lys Glu Val Asp Phe Cys Ile Ser Leu Leu 
225                 230                 235                 240 


Arg Glu Arg Phe Met Glu Cys Leu Met Ile Gly Arg Asp Leu Val Arg 
                245                 250                 255     


Leu Leu Gln Asn Val Ala Arg Ile Pro Glu Phe Glu Leu Leu Trp Lys 
            260                 265                 270         


Asp Ile Ile His Asn Pro Gln Ala Leu Ser Pro Gln Phe Thr Gly Ile 
        275                 280                 285             


Leu Gln Leu Leu Gln Ser Arg Thr Ser Arg Lys Phe Leu Ala Cys Arg 
    290                 295                 300                 


Leu Thr Pro Asp Met Glu Thr Lys Leu Leu Phe Met Thr Ser Arg Val 
305                 310                 315                 320 


Arg Phe Gly Gln Gln Lys Arg Tyr Gln Asp Trp Phe Gln Arg Gln Tyr 
                325                 330                 335     


Leu Ser Thr Pro Asp Ser Gln Ser Leu Arg Cys Asp Leu Ile Arg Tyr 
            340                 345                 350         


Ile Cys Gly Val Val His Pro Ser Asn Glu Val Leu Ser Ser Asp Ile 
        355                 360                 365             


Leu Pro Arg Trp Ala Ile Ile Gly Trp Leu Leu Thr Thr Cys Thr Ser 
    370                 375                 380                 


Asn Val Ala Ala Ser Asn Ala Lys Leu Ala Leu Phe Tyr Asp Trp Leu 
385                 390                 395                 400 


Phe Phe Ser Pro Asp Lys Asp Ser Ile Met Asn Ile Glu Pro Ala Ile 
                405                 410                 415     


Leu Val Met His His Ser Met Lys Pro His Pro Ala Ile Thr Ala Thr 
            420                 425                 430         


Leu Leu Asp Phe Met Cys Arg Ile Ile Pro Asn Phe Tyr Pro Pro Leu 
        435                 440                 445             


Glu Gly His Val Arg Gln Gly Val Phe Ser Ser Leu Asn His Ile Val 
    450                 455                 460                 


Glu Lys Arg Val Leu Ala His Leu Ala Pro Leu Phe Asp Asn Pro Lys 
465                 470                 475                 480 


Leu Asp Lys Glu Leu Arg Ala Met Leu Arg Glu Lys Phe Pro Glu Phe 
                485                 490                 495     


Cys Ser Ser Pro Ser Pro Pro Val Glu Val Lys Ile Glu Glu Pro Val 
            500                 505                 510         


Ser Met Glu Met Asp Asn His Met Ser Asp Lys Asp Glu Ser Cys Tyr 
        515                 520                 525             


Asp Asn Ala Glu Ala Ala Phe Ser Asp Asp Glu Glu Asp Leu Asn Ser 
    530                 535                 540                 


Lys Gly Lys Lys Arg Glu Phe Arg Phe His Pro Ile Lys Glu Thr Val 
545                 550                 555                 560 


Val Glu Glu Pro Val Asp Ile Thr Pro Tyr Leu Asp Gln Leu Asp Glu 
                565                 570                 575     


Ser Leu Arg Asp Lys Val Leu Gln Leu Gln Lys Gly Ser Asp Thr Glu 
            580                 585                 590         


Ala Gln Cys Glu Val Met Gln Glu Ile Val Asp Gln Val Leu Glu Glu 
        595                 600                 605             


Asp Phe Asp Ser Glu Gln Leu Ser Val Leu Ala Ser Cys Leu Gln Glu 
    610                 615                 620                 


Leu Phe Lys Ala His Phe Arg Gly Glu Val Leu Pro Glu Glu Ile Thr 
625                 630                 635                 640 


Glu Glu Ser Leu Glu Glu Ser Val Gly Lys Pro Leu Tyr Leu Ile Phe 
                645                 650                 655     


Arg Asn Leu Cys Gln Met Gln Glu Asp Asn Ser Ser Phe Ser Leu Leu 
            660                 665                 670         


Leu Asp Leu Leu Ser Glu Leu Tyr Gln Lys Gln Pro Lys Ile Gly Tyr 
        675                 680                 685             


His Leu Leu Tyr Tyr Leu Arg Ala Ser Lys Ala Ala Ala Gly Lys Met 
    690                 695                 700                 


Asn Leu Tyr Glu Ser Phe Ala Gln Ala Thr Gln Leu Gly Asp Leu His 
705                 710                 715                 720 


Thr Cys Leu Met Met Asp Met Lys Ala Cys Gln Glu Asp Asp Val Arg 
                725                 730                 735     


Leu Leu Cys His Leu Thr Pro Ser Ile Tyr Thr Glu Phe Pro Asp Glu 
            740                 745                 750         


Thr Leu Arg Ser Gly Glu Leu Leu Asn Met Ile Val Ala Val Ile Asp 
        755                 760                 765             


Ser Ala Gln Leu Gln Glu Leu Val Cys His Val Met Met Gly Asn Leu 
    770                 775                 780                 


Val Met Phe Arg Lys Asp Ser Val Leu Asn Ile Leu Ile Gln Ser Leu 
785                 790                 795                 800 


Asp Trp Glu Thr Phe Glu Gln Tyr Cys Ala Trp Gln Leu Phe Leu Ala 
                805                 810                 815     


His Asn Ile Pro Leu Glu Thr Ile Ile Pro Ile Leu Gln His Leu Lys 
            820                 825                 830         


Tyr Lys Glu His Pro Glu Ala Leu Ser Cys Leu Leu Leu Gln Leu Arg 
        835                 840                 845             


Arg Glu Lys Pro Ser Glu Glu Met Val Lys Met Val Leu Ser Arg Pro 
    850                 855                 860                 


Cys His Pro Asp Asp Gln Phe Thr Thr Ser Ile Leu Arg His Trp Cys 
865                 870                 875                 880 


Met Lys His Asp Glu Leu Leu Ala Glu His Ile Lys Ser Leu Leu Ile 
                885                 890                 895     


Lys Asn Asn Ser Leu Pro Arg Lys Arg Gln Ser Leu Arg Ser Ser Ser 
            900                 905                 910         


Ser Lys Leu Ala Gln Leu Thr Leu Glu Gln Ile Leu Glu His Leu Asp 
        915                 920                 925             


Asn Leu Arg Leu Asn Leu Thr Asn Thr Lys Gln Asn Phe Phe Ser Gln 
    930                 935                 940                 


Thr Pro Ile Leu Gln Ala Leu Gln His Val Gln Ala Ser Cys Asp Glu 
945                 950                 955                 960 


Ala His Lys Met Lys Phe Ser Asp Leu Phe Ser Leu Ala Glu Glu Tyr 
                965                 970                 975     


Glu Asp Ser Ser Thr Lys Pro Pro Lys Ser Arg Arg Lys Ala Ala Leu 
            980                 985                 990         


Ser Ser Pro Arg Ser Arg Lys Asn  Ala Thr Gln Pro Pro  Asn Ala Glu 
        995                 1000                 1005             


Glu Glu  Ser Gly Ser Ser Ser  Ala Ser Glu Glu Glu  Asp Thr Lys 
    1010                 1015                 1020             


Pro Lys  Pro Thr Lys Arg Lys  Arg Lys Gly Ser Ser  Ala Val Gly 
    1025                 1030                 1035             


Ser Asp  Ser Asp 
    1040         


<210>  7206
<211>  41
<212>  PRT
<213>  Homo Sapiens

<400>  7206

Thr Gln Pro Pro Asn Ala Glu Glu Glu Ser Gly Ser Ser Ser Ala Ser 
1               5                   10                  15      


Glu Glu Glu Asp Thr Lys Pro Lys Pro Thr Lys Arg Lys Arg Lys Gly 
            20                  25                  30          


Ser Ser Ala Val Gly Ser Asp Ser Asp 
        35                  40      


<210>  7207
<211>  280
<212>  PRT
<213>  Homo Sapiens

<400>  7207

Val Tyr Thr Tyr Leu Arg Leu Ile Val Asp His His Gly Thr Ala Gln 
1               5                   10                  15      


Leu Gln Ala Leu Arg Gln Lys Glu Val Asp Phe Cys Ile Ser Leu Leu 
            20                  25                  30          


Arg Glu Arg Phe Met Glu Cys Leu Met Ile Gly Arg Asp Leu Val Arg 
        35                  40                  45              


Leu Leu Gln Asn Val Ala Arg Ile Pro Glu Phe Glu Leu Leu Trp Lys 
    50                  55                  60                  


Asp Ile Ile His Asn Pro Gln Ala Leu Ser Pro Gln Phe Thr Gly Ile 
65                  70                  75                  80  


Leu Gln Leu Leu Gln Ser Arg Thr Ser Arg Lys Phe Leu Ala Cys Arg 
                85                  90                  95      


Leu Thr Pro Asp Met Glu Thr Lys Leu Leu Phe Met Thr Ser Arg Val 
            100                 105                 110         


Arg Phe Gly Gln Gln Lys Arg Tyr Gln Asp Trp Phe Gln Arg Gln Tyr 
        115                 120                 125             


Leu Ser Thr Pro Asp Ser Gln Ser Leu Arg Cys Asp Leu Ile Arg Tyr 
    130                 135                 140                 


Ile Cys Gly Val Val His Pro Ser Asn Glu Val Leu Ser Ser Asp Ile 
145                 150                 155                 160 


Leu Pro Arg Trp Ala Ile Ile Gly Trp Leu Leu Thr Thr Cys Thr Ser 
                165                 170                 175     


Asn Val Ala Ala Ser Asn Ala Lys Leu Ala Leu Phe Tyr Asp Trp Leu 
            180                 185                 190         


Phe Phe Ser Pro Asp Lys Asp Ser Ile Met Asn Ile Glu Pro Ala Ile 
        195                 200                 205             


Leu Val Met His His Ser Met Lys Pro His Pro Ala Ile Thr Ala Thr 
    210                 215                 220                 


Leu Leu Asp Phe Met Cys Arg Ile Ile Pro Asn Phe Tyr Pro Pro Leu 
225                 230                 235                 240 


Glu Gly His Val Arg Gln Gly Val Phe Ser Ser Leu Asn His Ile Val 
                245                 250                 255     


Glu Lys Arg Val Leu Ala Cys Lys Lys Tyr Trp Leu Tyr Leu Arg Leu 
            260                 265                 270         


Leu Gly Ile Cys Leu Leu Gly Ser 
        275                 280 


<210>  7208
<211>  49
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7208

Xaa Ser Gln Ser Leu Arg Cys Asp Leu Ile Arg Tyr Ile Cys Gly Val 
1               5                   10                  15      


Val His Pro Ser Asn Glu Val Leu Ser Ser Asp Ile Leu Pro Arg Trp 
            20                  25                  30          


Ala Ile Ile Gly Trp Leu Leu Thr Thr Cys Thr Thr Pro Ser Ser Pro 
        35                  40                  45              


Val 
    


<210>  7209
<211>  64
<212>  PRT
<213>  Homo Sapiens

<400>  7209

Met Asp Leu Asn Ser Ala Ser Thr Val Val Leu Gln Val Leu Thr Gln 
1               5                   10                  15      


Ala Thr Ser Gln Asp Thr Ala Val Leu Lys Pro Ala Glu Glu Gln Leu 
            20                  25                  30          


Lys Gln Trp Glu Thr Gln Pro Gly Phe Tyr Ser Val Leu Leu Asn Ile 
        35                  40                  45              


Phe Thr Asn His Thr Leu Asp Ile Asn Val Arg Trp Leu Ala Val Leu 
    50                  55                  60                  


<210>  7210
<211>  149
<212>  PRT
<213>  Homo Sapiens

<400>  7210

Met Asp Leu Asn Ser Ala Ser Thr Val Val Leu Gln Val Leu Thr Gln 
1               5                   10                  15      


Ala Thr Ser Gln Asp Thr Ala Val Leu Lys Pro Ala Glu Glu Gln Leu 
            20                  25                  30          


Lys Gln Trp Glu Thr Gln Pro Gly Phe Tyr Ser Val Leu Leu Asn Ile 
        35                  40                  45              


Phe Thr Asn His Thr Leu Asp Ile Asn Val Arg Trp Leu Ala Val Leu 
    50                  55                  60                  


Tyr Phe Lys His Gly Ile Asp Arg Tyr Trp Arg Arg Val Ala Pro His 
65                  70                  75                  80  


Ala Leu Ser Glu Glu Glu Lys Thr Thr Leu Arg Ala Gly Leu Ile Thr 
                85                  90                  95      


Asn Phe Asn Glu Pro Ile Asn Gln Ile Ala Thr Gln Ile Ala Val Leu 
            100                 105                 110         


Ile Ala Lys Val Ala Arg Leu Asp Cys Pro Arg Gln Trp Pro Glu Leu 
        115                 120                 125             


Ile Pro Thr Leu Ile Glu Ser Val Lys Val Gln Asp Asp Leu Arg Gln 
    130                 135                 140                 


His Arg Ala Leu Leu 
145                 


<210>  7211
<211>  162
<212>  PRT
<213>  Homo Sapiens

<400>  7211

Met Asp Leu Asn Ser Ala Ser Thr Val Val Leu Gln Val Leu Thr Gln 
1               5                   10                  15      


Ala Thr Ser Gln Asp Thr Ala Val Leu Lys Pro Ala Glu Glu Gln Leu 
            20                  25                  30          


Lys Gln Trp Glu Thr Gln Pro Gly Phe Tyr Ser Val Leu Leu Asn Ile 
        35                  40                  45              


Phe Thr Asn His Thr Leu Asp Ile Asn Val Arg Trp Leu Ala Val Leu 
    50                  55                  60                  


Tyr Phe Lys His Gly Ile Asp Arg Tyr Trp Arg Arg Val Ala Pro His 
65                  70                  75                  80  


Ala Leu Ser Glu Glu Glu Lys Thr Thr Leu Arg Ala Gly Leu Ile Thr 
                85                  90                  95      


Asn Phe Asn Glu Pro Ile Asn Gln Ile Ala Thr Gln Ile Ala Val Leu 
            100                 105                 110         


Ile Ala Lys Val Ala Arg Leu Asp Cys Pro Arg Gln Trp Pro Glu Leu 
        115                 120                 125             


Ile Pro Thr Leu Ile Glu Ser Val Lys Val Gln Asp Asp Leu Arg Gln 
    130                 135                 140                 


His Arg Ala Leu Leu Thr Phe Tyr His Val Thr Lys Thr Leu Ala Ser 
145                 150                 155                 160 


Lys Arg 
        


<210>  7212
<211>  975
<212>  PRT
<213>  Homo Sapiens

<400>  7212

Met Asp Leu Asn Ser Ala Ser Thr Val Val Leu Gln Val Leu Thr Gln 
1               5                   10                  15      


Ala Thr Ser Gln Asp Thr Ala Val Leu Lys Pro Ala Glu Glu Gln Leu 
            20                  25                  30          


Lys Gln Trp Glu Thr Gln Pro Gly Phe Tyr Ser Val Leu Leu Asn Ile 
        35                  40                  45              


Phe Thr Asn His Thr Leu Asp Ile Asn Val Arg Trp Leu Ala Val Leu 
    50                  55                  60                  


Tyr Phe Lys His Gly Ile Asp Arg Tyr Trp Arg Arg Val Ala Pro His 
65                  70                  75                  80  


Ala Leu Ser Glu Glu Glu Lys Thr Thr Leu Arg Ala Gly Leu Ile Thr 
                85                  90                  95      


Asn Phe Asn Glu Pro Ile Asn Gln Ile Ala Thr Gln Ile Ala Val Leu 
            100                 105                 110         


Ile Ala Lys Val Ala Arg Leu Asp Cys Pro Arg Gln Trp Pro Glu Leu 
        115                 120                 125             


Ile Pro Thr Leu Ile Glu Ser Val Lys Val Gln Asp Asp Leu Arg Gln 
    130                 135                 140                 


His Arg Ala Leu Leu Thr Phe Tyr His Val Thr Lys Thr Leu Ala Ser 
145                 150                 155                 160 


Lys Arg Leu Ala Ala Asp Arg Lys Leu Phe Tyr Asp Leu Ala Ser Gly 
                165                 170                 175     


Ile Tyr Asn Phe Ala Cys Ser Leu Trp Asn His His Thr Asp Thr Phe 
            180                 185                 190         


Leu Gln Glu Val Ser Ser Gly Asn Glu Ala Ala Ile Leu Ser Ser Leu 
        195                 200                 205             


Glu Arg Thr Leu Leu Ser Leu Lys Val Leu Arg Lys Leu Thr Val Asn 
    210                 215                 220                 


Gly Phe Val Glu Pro His Lys Asn Met Glu Val Met Gly Phe Leu His 
225                 230                 235                 240 


Gly Ile Phe Glu Arg Leu Lys Gln Phe Leu Glu Cys Ser Arg Ser Ile 
                245                 250                 255     


Gly Thr Asp Asn Val Cys Arg Asp Arg Leu Glu Lys Thr Ile Ile Leu 
            260                 265                 270         


Phe Thr Lys Val Leu Leu Asp Phe Leu Asp Gln His Pro Phe Ser Phe 
        275                 280                 285             


Thr Pro Leu Ile Gln Arg Ser Leu Glu Phe Ser Val Ser Tyr Val Phe 
    290                 295                 300                 


Thr Glu Val Gly Glu Gly Val Thr Phe Glu Arg Phe Ile Val Gln Cys 
305                 310                 315                 320 


Met Asn Leu Ile Lys Met Ile Val Lys Asn Tyr Ala Tyr Lys Pro Ser 
                325                 330                 335     


Lys Asn Phe Glu Asp Ser Ser Pro Glu Thr Leu Glu Ala His Lys Ile 
            340                 345                 350         


Lys Met Ala Phe Phe Thr Tyr Pro Thr Leu Thr Glu Ile Cys Arg Arg 
        355                 360                 365             


Leu Val Ser His Tyr Phe Leu Leu Thr Glu Glu Glu Leu Thr Met Trp 
    370                 375                 380                 


Glu Glu Asp Pro Glu Gly Phe Thr Val Glu Glu Thr Gly Gly Asp Ser 
385                 390                 395                 400 


Trp Lys Tyr Ser Leu Arg Pro Cys Thr Glu Val Leu Phe Ile Asp Ile 
                405                 410                 415     


Phe His Glu Tyr Asn Gln Thr Leu Thr Pro Val Leu Leu Glu Met Met 
            420                 425                 430         


Gln Thr Leu Gln Gly Pro Thr Asn Val Glu Asp Met Asn Ala Leu Leu 
        435                 440                 445             


Ile Lys Asp Ala Val Tyr Asn Ala Val Gly Leu Ala Ala Tyr Glu Leu 
    450                 455                 460                 


Phe Asp Ser Val Asp Phe Asp Gln Trp Phe Lys Asn Gln Leu Leu Pro 
465                 470                 475                 480 


Glu Leu Gln Val Ile His Asn Arg Tyr Lys Pro Leu Arg Arg Arg Val 
                485                 490                 495     


Ile Trp Leu Ile Gly Gln Trp Ile Ser Val Lys Phe Lys Ser Asp Leu 
            500                 505                 510         


Arg Pro Met Leu Tyr Glu Ala Ile Cys Asn Leu Leu Gln Asp Gln Asp 
        515                 520                 525             


Leu Val Val Arg Ile Glu Thr Ala Thr Thr Leu Lys Leu Thr Val Asp 
    530                 535                 540                 


Asp Phe Glu Phe Arg Thr Asp Gln Phe Leu Pro Tyr Leu Glu Thr Met 
545                 550                 555                 560 


Phe Thr Leu Leu Phe Gln Leu Leu Gln Gln Val Thr Glu Cys Asp Thr 
                565                 570                 575     


Lys Met His Val Leu His Val Leu Ser Cys Val Ile Glu Arg Val Asn 
            580                 585                 590         


Met Gln Ile Arg Pro Tyr Val Gly Cys Leu Val Gln Tyr Leu Pro Leu 
        595                 600                 605             


Leu Trp Lys Gln Ser Glu Glu His Asn Met Leu Arg Cys Ala Ile Leu 
    610                 615                 620                 


Thr Thr Leu Ile His Leu Val Gln Gly Leu Gly Ala Asp Ser Lys Asn 
625                 630                 635                 640 


Leu Tyr Pro Phe Leu Leu Pro Val Ile Gln Leu Ser Thr Asp Val Ser 
                645                 650                 655     


Gln Pro Pro His Val Tyr Leu Leu Glu Asp Gly Leu Glu Leu Trp Leu 
            660                 665                 670         


Val Thr Leu Glu Asn Ser Pro Cys Ile Thr Pro Glu Leu Leu Arg Ile 
        675                 680                 685             


Phe Gln Asn Met Ser Pro Leu Leu Glu Leu Ser Ser Glu Asn Leu Arg 
    690                 695                 700                 


Thr Cys Phe Lys Ile Ile Asn Gly Tyr Ile Phe Leu Ser Ser Thr Glu 
705                 710                 715                 720 


Phe Leu Gln Thr Tyr Ala Val Gly Leu Cys Gln Ser Phe Cys Glu Leu 
                725                 730                 735     


Leu Lys Glu Ile Thr Thr Glu Gly Gln Val Gln Val Leu Lys Val Val 
            740                 745                 750         


Glu Asn Ala Leu Lys Val Asn Pro Ile Leu Gly Pro Gln Met Phe Gln 
        755                 760                 765             


Pro Ile Leu Pro Tyr Val Phe Lys Gly Ile Ile Glu Gly Glu Arg Tyr 
    770                 775                 780                 


Pro Val Val Met Ser Thr Tyr Leu Gly Val Met Gly Arg Val Leu Leu 
785                 790                 795                 800 


Gln Asn Thr Ser Phe Phe Ser Ser Leu Leu Asn Glu Met Ala His Lys 
                805                 810                 815     


Phe Asn Gln Glu Met Asp Gln Leu Leu Gly Asn Met Ile Glu Met Trp 
            820                 825                 830         


Val Asp Arg Met Asp Asn Ile Thr Gln Pro Glu Arg Arg Lys Leu Ser 
        835                 840                 845             


Ala Leu Ala Leu Leu Ser Leu Leu Pro Ser Asp Asn Ser Val Ile Gln 
    850                 855                 860                 


Asp Lys Phe Cys Gly Ile Ile Asn Ile Ser Val Glu Gly Leu His Asp 
865                 870                 875                 880 


Val Met Thr Glu Asp Pro Glu Thr Gly Thr Tyr Lys Asp Cys Met Leu 
                885                 890                 895     


Met Ser His Leu Glu Glu Pro Lys Val Thr Glu Asp Glu Glu Pro Pro 
            900                 905                 910         


Thr Glu Gln Asp Lys Arg Lys Lys Met Leu Ala Leu Lys Asp Pro Val 
        915                 920                 925             


His Thr Val Ser Leu Gln Gln Phe Ile Tyr Glu Lys Leu Lys Ala Gln 
    930                 935                 940                 


Gln Glu Met Leu Gly Glu Gln Gly Phe Gln Ser Leu Met Glu Thr Val 
945                 950                 955                 960 


Asp Thr Glu Ile Val Thr Gln Leu Gln Glu Phe Leu Gln Gly Phe 
                965                 970                 975 


<210>  7213
<211>  863
<212>  PRT
<213>  Homo Sapiens

<400>  7213

Met Asp Leu Asn Ser Ala Ser Thr Val Val Leu Gln Val Leu Thr Gln 
1               5                   10                  15      


Ala Thr Ser Gln Asp Thr Ala Val Leu Lys Pro Ala Glu Glu Gln Leu 
            20                  25                  30          


Lys Gln Trp Glu Thr Gln Pro Gly Phe Tyr Ser Val Leu Leu Asn Ile 
        35                  40                  45              


Phe Thr Asn His Thr Leu Asp Ile Asn Val Arg Trp Leu Ala Val Leu 
    50                  55                  60                  


Tyr Phe Lys His Gly Ile Asp Arg Tyr Trp Arg Arg Val Ala Pro His 
65                  70                  75                  80  


Ala Leu Ser Glu Glu Glu Lys Thr Thr Leu Arg Ala Gly Leu Ile Thr 
                85                  90                  95      


Asn Phe Asn Glu Pro Ile Asn Gln Ile Ala Thr Gln Ile Ala Val Leu 
            100                 105                 110         


Ile Ala Lys Val Ala Arg Leu Asp Cys Pro Arg Gln Trp Pro Glu Leu 
        115                 120                 125             


Ile Pro Thr Leu Ile Glu Ser Val Lys Val Gln Asp Asp Leu Arg Gln 
    130                 135                 140                 


His Arg Ala Leu Leu Thr Phe Tyr His Val Thr Lys Thr Leu Ala Ser 
145                 150                 155                 160 


Lys Arg Leu Ala Ala Asp Arg Lys Leu Phe Tyr Asp Leu Ala Ser Gly 
                165                 170                 175     


Ile Tyr Asn Phe Ala Cys Ser Leu Trp Asn His His Thr Asp Thr Phe 
            180                 185                 190         


Leu Gln Glu Val Ser Ser Gly Asn Glu Ala Ala Ile Leu Ser Ser Leu 
        195                 200                 205             


Glu Arg Thr Leu Leu Ser Leu Lys Val Leu Arg Lys Leu Thr Val Asn 
    210                 215                 220                 


Gly Phe Val Glu Pro His Lys Asn Met Glu Val Met Gly Phe Leu His 
225                 230                 235                 240 


Gly Ile Phe Glu Arg Leu Lys Gln Phe Leu Glu Cys Ser Arg Ser Ile 
                245                 250                 255     


Gly Thr Asp Asn Val Cys Arg Asp Arg Leu Glu Lys Thr Ile Ile Leu 
            260                 265                 270         


Phe Thr Lys Val Leu Leu Asp Phe Leu Asp Gln His Pro Phe Ser Phe 
        275                 280                 285             


Thr Pro Leu Ile Gln Arg Ser Leu Glu Phe Ser Val Ser Tyr Val Phe 
    290                 295                 300                 


Thr Glu Val Gly Glu Gly Val Thr Phe Glu Arg Phe Ile Val Gln Cys 
305                 310                 315                 320 


Met Asn Leu Ile Lys Met Ile Val Lys Asn Tyr Ala Tyr Lys Pro Ser 
                325                 330                 335     


Lys Asn Phe Glu Asp Ser Ser Pro Glu Thr Leu Glu Ala His Lys Ile 
            340                 345                 350         


Lys Met Ala Phe Phe Thr Tyr Pro Thr Leu Thr Glu Ile Cys Arg Arg 
        355                 360                 365             


Leu Val Ser His Tyr Phe Leu Leu Thr Glu Glu Glu Leu Thr Met Trp 
    370                 375                 380                 


Glu Glu Asp Pro Glu Gly Phe Thr Val Glu Glu Thr Gly Gly Asp Ser 
385                 390                 395                 400 


Trp Lys Tyr Ser Leu Arg Pro Cys Thr Glu Val Leu Phe Ile Asp Ile 
                405                 410                 415     


Phe His Glu Tyr Asn Gln Thr Leu Thr Pro Val Leu Leu Glu Met Met 
            420                 425                 430         


Gln Thr Leu Gln Gly Pro Thr Asn Val Glu Asp Met Asn Ala Leu Leu 
        435                 440                 445             


Ile Lys Asp Ala Val Tyr Asn Ala Val Gly Leu Ala Ala Tyr Glu Leu 
    450                 455                 460                 


Phe Asp Ser Val Asp Phe Asp Gln Trp Phe Lys Asn Gln Leu Leu Pro 
465                 470                 475                 480 


Glu Leu Gln Val Ile His Asn Arg Tyr Lys Pro Leu Arg Arg Arg Val 
                485                 490                 495     


Ile Trp Leu Ile Gly Gln Trp Ile Ser Val Lys Phe Lys Ser Asp Leu 
            500                 505                 510         


Arg Pro Met Leu Tyr Glu Ala Ile Cys Asn Leu Leu Gln Asp Gln Asp 
        515                 520                 525             


Leu Val Val Arg Ile Glu Thr Ala Thr Thr Leu Lys Leu Thr Val Asp 
    530                 535                 540                 


Asp Phe Glu Phe Arg Thr Asp Gln Phe Leu Pro Tyr Leu Glu Thr Met 
545                 550                 555                 560 


Phe Thr Leu Leu Phe Gln Leu Leu Gln Gln Val Thr Glu Cys Asp Thr 
                565                 570                 575     


Lys Met His Val Leu His Val Leu Ser Cys Val Ile Glu Arg Val Asn 
            580                 585                 590         


Met Gln Ile Arg Pro Tyr Val Gly Cys Leu Val Gln Tyr Leu Pro Leu 
        595                 600                 605             


Leu Trp Lys Gln Ser Glu Glu His Asn Met Leu Arg Cys Ala Ile Leu 
    610                 615                 620                 


Thr Thr Leu Ile His Leu Val Gln Gly Leu Gly Ala Asp Ser Lys Asn 
625                 630                 635                 640 


Leu Tyr Pro Phe Leu Leu Pro Val Ile Gln Leu Ser Thr Asp Val Ser 
                645                 650                 655     


Gln Pro Pro His Val Tyr Leu Leu Glu Asp Gly Leu Glu Leu Trp Leu 
            660                 665                 670         


Val Thr Leu Glu Asn Ser Pro Cys Ile Thr Pro Glu Leu Leu Arg Ile 
        675                 680                 685             


Phe Gln Asn Met Ser Pro Leu Leu Glu Leu Ser Ser Glu Asn Leu Arg 
    690                 695                 700                 


Thr Cys Phe Lys Ile Ile Asn Gly Tyr Ile Phe Leu Ser Ser Thr Glu 
705                 710                 715                 720 


Phe Leu Gln Thr Tyr Ala Val Gly Leu Cys Gln Ser Phe Cys Glu Leu 
                725                 730                 735     


Leu Lys Glu Ile Thr Thr Glu Gly Gln Val Gln Val Leu Lys Val Val 
            740                 745                 750         


Glu Asn Ala Leu Lys Val Asn Pro Ile Leu Gly Pro Gln Met Phe Gln 
        755                 760                 765             


Pro Ile Leu Pro Tyr Val Phe Lys Gly Ile Ile Glu Gly Glu Arg Tyr 
    770                 775                 780                 


Pro Val Val Met Ser Thr Tyr Leu Gly Val Met Gly Arg Val Leu Leu 
785                 790                 795                 800 


Gln Asn Thr Ser Phe Phe Ser Ser Leu Leu Asn Glu Met Ala His Lys 
                805                 810                 815     


Phe Asn Gln Glu Met Asp Gln Leu Leu Gly Asn Met Ile Glu Met Trp 
            820                 825                 830         


Val Asp Arg Met Asp Asn Ile Thr Gln Pro Glu Arg Arg Lys Leu Ser 
        835                 840                 845             


Ala Leu Ala Leu Leu Ser Leu Leu Pro Ser Asp Asn Ser Gln Phe 
    850                 855                 860             


<210>  7214
<211>  59
<212>  PRT
<213>  Homo Sapiens

<400>  7214

Met Asp Gln Leu Leu Gly Asn Met Ile Glu Met Trp Val Asp Arg Met 
1               5                   10                  15      


Asp Asn Ile Thr Gln Pro Glu Arg Arg Lys Leu Ser Ala Leu Ala Leu 
            20                  25                  30          


Leu Ser Leu Leu Pro Ser Asp Asn Ser Phe Leu Tyr Pro Trp Gln Pro 
        35                  40                  45              


Leu Phe Tyr Thr Leu Thr Val Lys Glu Pro Met 
    50                  55                  


<210>  7215
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  7215

Met Thr Glu Asp Pro Glu Thr Gly Thr Tyr Lys Asp Cys Met Leu Met 
1               5                   10                  15      


Ser His Leu Glu Glu Pro Lys Val Thr Glu Asp Glu Glu Pro Pro Thr 
            20                  25                  30          


Glu Gln Asp Lys Arg Lys Lys Met Leu Ala Leu Lys Asp Pro Val His 
        35                  40                  45              


Thr Val Ser Leu Gln Gln Phe Ile Tyr Glu Lys Leu Lys Ala Gln Gln 
    50                  55                  60                  


Glu Met Leu Gly Glu Gln Gly Phe Gln Ser Leu Met Glu Thr Val Asp 
65                  70                  75                  80  


Thr Glu Ile Val Thr Gln Leu Gln Glu Phe Leu Gln Gly Phe 
                85                  90                  


<210>  7216
<211>  1015
<212>  PRT
<213>  Homo Sapiens

<400>  7216

Met Val Gln Pro Ile Ile His Leu Gly Tyr Val Val Tyr Ser Leu Leu 
1               5                   10                  15      


Tyr Leu Gly Tyr Lys Pro Val Gln His Val Thr Ala Leu Asn Thr Val 
            20                  25                  30          


Ser Ser Cys His Lys Met Val Ser Met Asp Leu Asn Ser Ala Ser Thr 
        35                  40                  45              


Val Val Leu Gln Val Leu Thr Gln Ala Thr Ser Gln Asp Thr Ala Val 
    50                  55                  60                  


Leu Lys Pro Ala Glu Glu Gln Leu Lys Gln Trp Glu Thr Gln Pro Gly 
65                  70                  75                  80  


Phe Tyr Ser Val Leu Leu Asn Ile Phe Thr Asn His Thr Leu Asp Ile 
                85                  90                  95      


Asn Val Arg Trp Leu Ala Val Leu Tyr Phe Lys His Gly Ile Asp Arg 
            100                 105                 110         


Tyr Trp Arg Arg Val Ala Pro His Ala Leu Ser Glu Glu Glu Lys Thr 
        115                 120                 125             


Thr Leu Arg Ala Gly Leu Ile Thr Asn Phe Asn Glu Pro Ile Asn Gln 
    130                 135                 140                 


Ile Ala Thr Gln Ile Ala Val Leu Ile Ala Lys Val Ala Arg Leu Asp 
145                 150                 155                 160 


Cys Pro Arg Gln Trp Pro Glu Leu Ile Pro Thr Leu Ile Glu Ser Val 
                165                 170                 175     


Lys Val Gln Asp Asp Leu Arg Gln His Arg Ala Leu Leu Thr Phe Tyr 
            180                 185                 190         


His Val Thr Lys Thr Leu Ala Ser Lys Arg Leu Ala Ala Asp Arg Lys 
        195                 200                 205             


Leu Phe Tyr Asp Leu Ala Ser Gly Ile Tyr Asn Phe Ala Cys Ser Leu 
    210                 215                 220                 


Trp Asn His His Thr Asp Thr Phe Leu Gln Glu Val Ser Ser Gly Asn 
225                 230                 235                 240 


Glu Ala Ala Ile Leu Ser Ser Leu Glu Arg Thr Leu Leu Ser Leu Lys 
                245                 250                 255     


Val Leu Arg Lys Leu Thr Val Asn Gly Phe Val Glu Pro His Lys Asn 
            260                 265                 270         


Met Glu Val Met Gly Phe Leu His Gly Ile Phe Glu Arg Leu Lys Gln 
        275                 280                 285             


Phe Leu Glu Cys Ser Arg Ser Ile Gly Thr Asp Asn Val Cys Arg Asp 
    290                 295                 300                 


Arg Leu Glu Lys Thr Ile Ile Leu Phe Thr Lys Val Leu Leu Asp Phe 
305                 310                 315                 320 


Leu Asp Gln His Pro Phe Ser Phe Thr Pro Leu Ile Gln Arg Ser Leu 
                325                 330                 335     


Glu Phe Ser Val Ser Tyr Val Phe Thr Glu Val Gly Glu Gly Val Thr 
            340                 345                 350         


Phe Glu Arg Phe Ile Val Gln Cys Met Asn Leu Ile Lys Met Ile Val 
        355                 360                 365             


Lys Asn Tyr Ala Tyr Lys Pro Ser Lys Asn Phe Glu Asp Ser Ser Pro 
    370                 375                 380                 


Glu Thr Leu Glu Ala His Lys Ile Lys Met Ala Phe Phe Thr Tyr Pro 
385                 390                 395                 400 


Thr Leu Thr Glu Ile Cys Arg Arg Leu Val Ser His Tyr Phe Leu Leu 
                405                 410                 415     


Thr Glu Glu Glu Leu Thr Met Trp Glu Glu Asp Pro Glu Gly Phe Thr 
            420                 425                 430         


Val Glu Glu Thr Gly Gly Asp Ser Trp Lys Tyr Ser Leu Arg Pro Cys 
        435                 440                 445             


Thr Glu Val Leu Phe Ile Asp Ile Phe His Glu Tyr Asn Gln Thr Leu 
    450                 455                 460                 


Thr Pro Val Leu Leu Glu Met Met Gln Thr Leu Gln Gly Pro Thr Asn 
465                 470                 475                 480 


Val Glu Asp Met Asn Ala Leu Leu Ile Lys Asp Ala Val Tyr Asn Ala 
                485                 490                 495     


Val Gly Leu Ala Ala Tyr Glu Leu Phe Asp Ser Val Asp Phe Asp Gln 
            500                 505                 510         


Trp Phe Lys Asn Gln Leu Leu Pro Glu Leu Gln Val Ile His Asn Arg 
        515                 520                 525             


Tyr Lys Pro Leu Arg Arg Arg Val Ile Trp Leu Ile Gly Gln Trp Ile 
    530                 535                 540                 


Ser Val Lys Phe Lys Ser Asp Leu Arg Pro Met Leu Tyr Glu Ala Ile 
545                 550                 555                 560 


Cys Asn Leu Leu Gln Asp Gln Asp Leu Val Val Arg Ile Glu Thr Ala 
                565                 570                 575     


Thr Thr Leu Lys Leu Thr Val Asp Asp Phe Glu Phe Arg Thr Asp Gln 
            580                 585                 590         


Phe Leu Pro Tyr Leu Glu Thr Met Phe Thr Leu Leu Phe Gln Leu Leu 
        595                 600                 605             


Gln Gln Val Thr Glu Cys Asp Thr Lys Met His Val Leu His Val Leu 
    610                 615                 620                 


Ser Cys Val Ile Glu Arg Val Asn Met Gln Ile Arg Pro Tyr Val Gly 
625                 630                 635                 640 


Cys Leu Val Gln Tyr Leu Pro Leu Leu Trp Lys Gln Ser Glu Glu His 
                645                 650                 655     


Asn Met Leu Arg Cys Ala Ile Leu Thr Thr Leu Ile His Leu Val Gln 
            660                 665                 670         


Gly Leu Gly Ala Asp Ser Lys Asn Leu Tyr Pro Phe Leu Leu Pro Val 
        675                 680                 685             


Ile Gln Leu Ser Thr Asp Val Ser Gln Pro Pro His Val Tyr Leu Leu 
    690                 695                 700                 


Glu Asp Gly Leu Glu Leu Trp Leu Val Thr Leu Glu Asn Ser Pro Cys 
705                 710                 715                 720 


Ile Thr Pro Glu Leu Leu Arg Ile Phe Gln Asn Met Ser Pro Leu Leu 
                725                 730                 735     


Glu Leu Ser Ser Glu Asn Leu Arg Thr Cys Phe Lys Ile Ile Asn Gly 
            740                 745                 750         


Tyr Ile Phe Leu Ser Ser Thr Glu Phe Leu Gln Thr Tyr Ala Val Gly 
        755                 760                 765             


Leu Cys Gln Ser Phe Cys Glu Leu Leu Lys Glu Ile Thr Thr Glu Gly 
    770                 775                 780                 


Gln Val Gln Val Leu Lys Val Val Glu Asn Ala Leu Lys Val Asn Pro 
785                 790                 795                 800 


Ile Leu Gly Pro Gln Met Phe Gln Pro Ile Leu Pro Tyr Val Phe Lys 
                805                 810                 815     


Gly Ile Ile Glu Gly Glu Arg Tyr Pro Val Val Met Ser Thr Tyr Leu 
            820                 825                 830         


Gly Val Met Gly Arg Val Leu Leu Gln Asn Thr Ser Phe Phe Ser Ser 
        835                 840                 845             


Leu Leu Asn Glu Met Ala His Lys Phe Asn Gln Glu Met Asp Gln Leu 
    850                 855                 860                 


Leu Gly Asn Met Ile Glu Met Trp Val Asp Arg Met Asp Asn Ile Thr 
865                 870                 875                 880 


Gln Pro Glu Arg Arg Lys Leu Ser Ala Leu Ala Leu Leu Ser Leu Leu 
                885                 890                 895     


Pro Ser Asp Asn Ser Val Ile Gln Asp Lys Phe Cys Gly Ile Ile Asn 
            900                 905                 910         


Ile Ser Val Glu Gly Leu His Asp Val Met Thr Glu Asp Pro Glu Thr 
        915                 920                 925             


Gly Thr Tyr Lys Asp Cys Met Leu Met Ser His Leu Glu Glu Pro Lys 
    930                 935                 940                 


Val Thr Glu Asp Glu Glu Pro Pro Thr Glu Gln Asp Lys Arg Lys Lys 
945                 950                 955                 960 


Met Leu Ala Leu Lys Asp Pro Val His Thr Val Ser Leu Gln Gln Phe 
                965                 970                 975     


Ile Tyr Glu Lys Leu Lys Ala Gln Gln Glu Met Leu Gly Glu Gln Gly 
            980                 985                 990         


Phe Gln Ser Leu Met Glu Thr Val  Asp Thr Glu Ile Val  Thr Gln Leu 
        995                 1000                 1005             


Gln Glu  Phe Leu Gln Gly Phe  
    1010                 1015 


<210>  7217
<211>  160
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7217

Xaa Leu Arg Cys Ala Ile Leu Thr Thr Leu Ile His Leu Val Gln Val 
1               5                   10                  15      


Val Glu Asn Ala Leu Lys Val Asn Pro Ile Leu Gly Pro Gln Met Phe 
            20                  25                  30          


Gln Pro Ile Leu Pro Tyr Val Phe Lys Gly Ile Ile Glu Gly Glu Arg 
        35                  40                  45              


Tyr Pro Val Val Met Ser Thr Tyr Leu Gly Val Met Gly Arg Val Leu 
    50                  55                  60                  


Leu Gln Asn Thr Ser Phe Phe Ser Ser Leu Leu Asn Glu Met Ala His 
65                  70                  75                  80  


Lys Phe Asn Gln Glu Met Asp Gln Leu Leu Gly Asn Met Ile Glu Met 
                85                  90                  95      


Trp Val Asp Arg Met Asp Asn Ile Thr Gln Pro Glu Arg Arg Lys Leu 
            100                 105                 110         


Ser Ala Leu Ala Leu Leu Ser Leu Leu Pro Ser Asp Asn Ser Val Ile 
        115                 120                 125             


Gln Asp Lys Phe Cys Gly Ile Ile Asn Ile Ser Val Glu Gly Leu His 
    130                 135                 140                 


Asp Val Met Thr Glu Asp Pro Glu Thr Gly Thr Tyr Lys Asp Trp Pro 
145                 150                 155                 160 


<210>  7218
<211>  1041
<212>  PRT
<213>  Homo Sapiens

<400>  7218

Met Ala Ala Ala Ala Ala Ala Gly Ala Ala Ser Gly Leu Pro Gly Pro 
1               5                   10                  15      


Val Ala Gln Gly Leu Lys Glu Ala Leu Val Asp Thr Leu Thr Gly Ile 
            20                  25                  30          


Leu Ser Pro Val Gln Glu Val Arg Ala Ala Ala Glu Glu Gln Ile Lys 
        35                  40                  45              


Val Leu Glu Val Thr Glu Glu Phe Gly Val His Leu Ala Glu Leu Thr 
    50                  55                  60                  


Val Asp Pro Gln Gly Ala Leu Ala Ile Arg Gln Leu Ala Ser Val Ile 
65                  70                  75                  80  


Leu Lys Gln Tyr Val Glu Thr His Trp Cys Ala Gln Ser Glu Lys Phe 
                85                  90                  95      


Arg Pro Pro Glu Thr Thr Glu Arg Ala Lys Ile Val Ile Arg Glu Leu 
            100                 105                 110         


Leu Pro Asn Gly Leu Arg Glu Ser Ile Ser Lys Val Arg Ser Ser Val 
        115                 120                 125             


Ala Tyr Ala Val Ser Ala Ile Ala His Trp Asp Trp Pro Glu Ala Trp 
    130                 135                 140                 


Pro Gln Leu Phe Asn Leu Leu Met Glu Met Leu Val Ser Gly Asp Leu 
145                 150                 155                 160 


Asn Ala Val His Gly Ala Met Arg Val Leu Thr Glu Phe Thr Arg Glu 
                165                 170                 175     


Val Thr Asp Thr Gln Met Pro Leu Val Ala Pro Val Ile Leu Pro Glu 
            180                 185                 190         


Met Tyr Lys Ile Phe Thr Met Ala Glu Val Tyr Gly Ile Arg Thr Arg 
        195                 200                 205             


Ser Arg Ala Val Glu Ile Phe Thr Thr Cys Ala His Met Ile Cys Asn 
    210                 215                 220                 


Met Glu Glu Leu Glu Lys Gly Ala Ala Lys Val Leu Ile Phe Pro Val 
225                 230                 235                 240 


Val Gln Gln Phe Thr Glu Ala Phe Val Gln Ala Leu Gln Ile Pro Asp 
                245                 250                 255     


Gly Pro Thr Ser Asp Ser Gly Phe Lys Met Glu Val Leu Lys Ala Val 
            260                 265                 270         


Thr Ala Leu Val Lys Asn Phe Pro Lys His Met Val Ser Ser Met Gln 
        275                 280                 285             


Gln Ile Leu Pro Ile Val Trp Asn Thr Leu Thr Glu Ser Ala Ala Phe 
    290                 295                 300                 


Tyr Val Arg Thr Glu Val Asn Tyr Thr Glu Glu Val Glu Asp Pro Val 
305                 310                 315                 320 


Asp Ser Asp Gly Glu Val Leu Gly Phe Glu Asn Leu Val Phe Ser Ile 
                325                 330                 335     


Phe Glu Phe Val His Ala Leu Leu Glu Asn Ser Lys Phe Lys Ser Thr 
            340                 345                 350         


Val Lys Lys Ala Leu Pro Glu Leu Ile Tyr Tyr Ile Ile Leu Tyr Met 
        355                 360                 365             


Gln Ile Thr Glu Glu Gln Ile Lys Val Trp Thr Ala Asn Pro Gln Gln 
    370                 375                 380                 


Phe Val Glu Asp Glu Asp Asp Asp Thr Phe Ser Tyr Thr Val Arg Ile 
385                 390                 395                 400 


Ala Ala Gln Asp Leu Leu Leu Ala Val Ala Thr Asp Phe Gln Asn Glu 
                405                 410                 415     


Ser Ala Ala Ala Leu Ala Ala Ala Ala Thr Arg His Leu Gln Glu Ala 
            420                 425                 430         


Glu Gln Thr Lys Asn Ser Gly Thr Glu His Trp Trp Lys Ile His Glu 
        435                 440                 445             


Ala Cys Met Leu Ala Leu Gly Ser Val Lys Ala Ile Ile Thr Asp Ser 
    450                 455                 460                 


Val Lys Asn Gly Arg Ile His Phe Asp Met His Gly Phe Leu Thr Asn 
465                 470                 475                 480 


Val Ile Leu Ala Asp Leu Asn Leu Ser Val Ser Pro Phe Leu Leu Gly 
                485                 490                 495     


Arg Ala Leu Trp Ala Ala Ser Arg Phe Thr Val Ala Met Ser Pro Glu 
            500                 505                 510         


Leu Ile Gln Gln Phe Leu Gln Ala Thr Val Ser Gly Leu His Glu Thr 
        515                 520                 525             


Gln Pro Pro Ser Val Arg Ile Ser Ala Val Arg Ala Ile Trp Gly Tyr 
    530                 535                 540                 


Cys Asp Gln Leu Lys Val Ser Glu Ser Thr His Val Leu Gln Pro Phe 
545                 550                 555                 560 


Leu Pro Ser Ile Leu Asp Gly Leu Ile His Leu Ala Ala Gln Phe Ser 
                565                 570                 575     


Ser Glu Val Leu Asn Leu Val Met Glu Thr Leu Cys Ile Val Cys Thr 
            580                 585                 590         


Val Asp Pro Glu Phe Thr Ala Ser Met Glu Ser Lys Ile Cys Pro Phe 
        595                 600                 605             


Thr Ile Ala Ile Phe Leu Lys Tyr Ser Asn Asp Pro Val Val Ala Ser 
    610                 615                 620                 


Leu Ala Gln Asp Ile Phe Lys Glu Leu Ser Gln Ile Glu Ala Cys Gln 
625                 630                 635                 640 


Gly Pro Met Gln Met Arg Leu Ile Pro Thr Leu Val Ser Ile Met Gln 
                645                 650                 655     


Ala Pro Ala Asp Lys Ile Pro Ala Gly Leu Cys Ala Thr Ala Ile Asp 
            660                 665                 670         


Ile Leu Thr Thr Val Val Arg Asn Thr Lys Pro Pro Leu Ser Gln Leu 
        675                 680                 685             


Leu Ile Cys Gln Ala Phe Pro Ala Val Ala Gln Cys Thr Leu His Thr 
    690                 695                 700                 


Asp Asp Asn Ala Thr Met Gln Asn Gly Gly Glu Cys Leu Arg Ala Tyr 
705                 710                 715                 720 


Val Ser Val Thr Leu Glu Gln Val Ala Gln Trp His Asp Glu Gln Gly 
                725                 730                 735     


His Asn Gly Leu Trp Tyr Val Met Gln Val Val Ser Gln Leu Leu Asp 
            740                 745                 750         


Pro Arg Thr Ser Glu Phe Thr Ala Ala Phe Val Gly Arg Leu Val Ser 
        755                 760                 765             


Thr Leu Ile Ser Lys Ala Gly Arg Glu Leu Gly Glu Asn Leu Asp Gln 
    770                 775                 780                 


Ile Leu Arg Ala Ile Leu Ser Lys Met Gln Gln Ala Glu Thr Leu Ser 
785                 790                 795                 800 


Val Met Gln Ser Leu Ile Met Val Phe Ala His Leu Val His Thr Gln 
                805                 810                 815     


Leu Glu Pro Leu Leu Glu Phe Leu Cys Ser Leu Pro Gly Pro Thr Gly 
            820                 825                 830         


Lys Pro Ala Leu Glu Phe Val Met Ala Glu Trp Thr Ser Arg Gln His 
        835                 840                 845             


Leu Phe Tyr Gly Gln Tyr Glu Gly Lys Val Ser Ser Val Ala Leu Cys 
    850                 855                 860                 


Lys Leu Leu Gln His Gly Ile Asn Ala Asp Asp Lys Arg Leu Gln Asp 
865                 870                 875                 880 


Ile Arg Val Lys Gly Glu Glu Ile Tyr Ser Met Asp Glu Gly Ile Arg 
                885                 890                 895     


Thr Arg Ser Lys Ser Ala Lys Asn Pro Glu Arg Trp Thr Asn Ile Pro 
            900                 905                 910         


Leu Leu Val Lys Ile Leu Lys Leu Ile Ile Asn Glu Leu Ser Asn Val 
        915                 920                 925             


Met Glu Ala Asn Ala Ala Arg Gln Ala Thr Pro Ala Glu Trp Ser Gln 
    930                 935                 940                 


Asp Asp Ser Asn Asp Met Trp Glu Asp Gln Glu Glu Glu Glu Glu Glu 
945                 950                 955                 960 


Glu Glu Asp Gly Leu Ala Gly Gln Leu Leu Ser Asp Ile Leu Ala Thr 
                965                 970                 975     


Ser Lys Tyr Glu Glu Asp Tyr Tyr Glu Asp Asp Glu Glu Asp Asp Pro 
            980                 985                 990         


Asp Ala Leu Lys Asp Pro Leu Tyr  Gln Ile Asp Leu Gln  Ala Tyr Leu 
        995                 1000                 1005             


Thr Asp  Phe Leu Cys Gln Phe  Ala Gln Gln Pro Cys  Tyr Ile Met 
    1010                 1015                 1020             


Phe Ser  Gly His Leu Asn Asp  Asn Glu Arg Arg Val  Leu Gln Thr 
    1025                 1030                 1035             


Ile Gly  Ile 
    1040     


<210>  7219
<211>  155
<212>  PRT
<213>  Homo Sapiens

<400>  7219

Ser Asn Val Met Glu Ala Asn Ala Ala Arg Gln Ala Thr Pro Ala Glu 
1               5                   10                  15      


Trp Ser Gln Asp Asp Ser Asn Asp Met Trp Glu Asp Gln Glu Glu Glu 
            20                  25                  30          


Glu Glu Glu Glu Glu Asp Gly Leu Ala Gly Gln Leu Leu Ser Asp Ile 
        35                  40                  45              


Leu Ala Thr Ser Lys Tyr Glu Glu Asp Tyr Tyr Glu Asp Asp Glu Glu 
    50                  55                  60                  


Asp Asp Pro Asp Ala Leu Lys Asp Pro Leu Tyr Gln Ile Asp Leu Gln 
65                  70                  75                  80  


Ala Thr Leu Met Thr Met Arg Gly Glu Phe Tyr Arg Pro Ser Ala Ser 
                85                  90                  95      


Lys Lys Gly Ser Leu Ser Thr Phe Ala Pro Ser Gly Pro Ala Ala Asn 
            100                 105                 110         


His Phe Ala Ala Leu Thr Gly Leu Glu Met His Phe Leu Leu Asn Leu 
        115                 120                 125             


Lys Trp His Leu Asp Pro Trp Pro Leu Ala Ser Ala Val Thr Leu Met 
    130                 135                 140                 


Thr Ile Gln Thr Arg Leu Thr Gly Ala Val Thr 
145                 150                 155 


<210>  7220
<211>  127
<212>  PRT
<213>  Homo Sapiens

<400>  7220

Met Asp Thr Gln Asn Leu Glu Lys Thr Ala Ile Lys Ile Gln Ser Trp 
1               5                   10                  15      


Trp Arg Gly Asn Met Val Arg Arg Thr Leu Leu Gln Ala Ala Leu Arg 
            20                  25                  30          


Ala Trp Val Ile Gln Cys Trp Trp Arg Ser Met Gln Ala Lys Met Leu 
        35                  40                  45              


Glu Gln Arg Arg Arg Leu Ala Leu Arg Leu Tyr Thr Cys Gln Glu Trp 
    50                  55                  60                  


Ala Val Val Lys Val Gln Ala Gln Val Arg Met Trp Gln Ala Arg Arg 
65                  70                  75                  80  


Arg Phe Leu Gln Ala Arg Gln Ala Ala Cys Ile Ile Gln Ser His Trp 
                85                  90                  95      


Arg Trp His Ala Ser Gln Thr Arg Gly Leu Ile Arg Gly His Tyr Glu 
            100                 105                 110         


Val Arg Ala Ser Arg Leu Glu Leu Asp Ile Glu Ile Leu Met Thr 
        115                 120                 125         


<210>  7221
<211>  107
<212>  PRT
<213>  Homo Sapiens

<400>  7221

Met Val Arg Arg Thr Leu Leu Gln Ala Ala Leu Arg Ala Trp Val Ile 
1               5                   10                  15      


Gln Cys Trp Trp Arg Ser Met Gln Ala Lys Met Leu Glu Gln Arg Arg 
            20                  25                  30          


Arg Leu Ala Leu Arg Leu Tyr Thr Cys Gln Glu Trp Ala Val Val Lys 
        35                  40                  45              


Val Gln Ala Gln Val Arg Met Trp Gln Ala Arg Arg Arg Phe Leu Gln 
    50                  55                  60                  


Ala Arg Gln Ala Ala Cys Ile Ile Gln Ser His Trp Arg Trp His Ala 
65                  70                  75                  80  


Ser Gln Thr Arg Gly Leu Ile Arg Gly His Tyr Glu Val Arg Ala Ser 
                85                  90                  95      


Arg Leu Glu Leu Asp Ile Glu Ile Leu Met Thr 
            100                 105         


<210>  7222
<211>  596
<212>  PRT
<213>  Homo Sapiens

<400>  7222

Met Ala Gly Asn Cys Gly Ala Arg Gly Ala Leu Ser Ala His Thr Leu 
1               5                   10                  15      


Leu Phe Asp Leu Pro Pro Ala Leu Leu Gly Glu Leu Cys Ala Val Leu 
            20                  25                  30          


Asp Ser Cys Asp Gly Ala Leu Gly Trp Arg Gly Leu Ala Glu Arg Leu 
        35                  40                  45              


Ser Ser Ser Trp Leu Asp Val Arg His Ile Glu Lys Tyr Val Asp Gln 
    50                  55                  60                  


Gly Lys Ser Gly Thr Arg Glu Leu Leu Trp Ser Trp Ala Gln Lys Asn 
65                  70                  75                  80  


Lys Thr Ile Gly Asp Leu Leu Gln Val Leu Gln Glu Met Gly His Arg 
                85                  90                  95      


Arg Ala Ile His Leu Ile Thr Asn Tyr Gly Ala Val Leu Ser Pro Ser 
            100                 105                 110         


Glu Lys Ser Tyr Gln Glu Gly Gly Phe Pro Asn Ile Leu Phe Lys Glu 
        115                 120                 125             


Thr Ala Asn Val Thr Val Asp Asn Val Leu Ile Pro Glu His Asn Glu 
    130                 135                 140                 


Lys Gly Ile Leu Leu Lys Ser Ser Ile Ser Phe Gln Asn Ile Ile Glu 
145                 150                 155                 160 


Gly Thr Arg Asn Phe His Lys Asp Phe Leu Ile Gly Glu Gly Glu Ile 
                165                 170                 175     


Phe Glu Val Tyr Arg Val Glu Ile Gln Asn Leu Thr Tyr Ala Val Lys 
            180                 185                 190         


Leu Phe Lys Gln Glu Lys Lys Met Gln Cys Lys Lys His Trp Lys Arg 
        195                 200                 205             


Phe Leu Ser Glu Leu Glu Val Leu Leu Leu Phe His His Pro Asn Ile 
    210                 215                 220                 


Leu Glu Leu Ala Ala Tyr Phe Thr Glu Thr Glu Lys Phe Cys Leu Ile 
225                 230                 235                 240 


Tyr Pro Tyr Met Arg Asn Gly Thr Leu Phe Asp Arg Leu Gln Cys Val 
                245                 250                 255     


Gly Asp Thr Ala Pro Leu Pro Trp His Ile Arg Ile Gly Ile Leu Ile 
            260                 265                 270         


Gly Ile Ser Lys Ala Ile His Tyr Leu His Asn Val Gln Pro Cys Ser 
        275                 280                 285             


Val Ile Cys Gly Ser Ile Ser Ser Ala Asn Ile Leu Leu Asp Asp Gln 
    290                 295                 300                 


Phe Gln Pro Lys Leu Thr Asp Phe Ala Met Ala His Phe Arg Ser His 
305                 310                 315                 320 


Leu Glu His Gln Ser Cys Thr Ile Asn Met Thr Ser Ser Ser Ser Lys 
                325                 330                 335     


His Leu Trp Tyr Met Pro Glu Glu Tyr Ile Arg Gln Gly Lys Leu Ser 
            340                 345                 350         


Ile Lys Thr Asp Val Tyr Ser Phe Gly Ile Val Ile Met Glu Val Leu 
        355                 360                 365             


Thr Gly Cys Arg Val Val Leu Asp Asp Pro Lys His Ile Gln Leu Arg 
    370                 375                 380                 


Asp Leu Leu Arg Glu Leu Met Glu Lys Arg Gly Leu Asp Ser Cys Leu 
385                 390                 395                 400 


Ser Phe Leu Asp Lys Lys Val Pro Pro Cys Pro Arg Asn Phe Ser Ala 
                405                 410                 415     


Lys Leu Phe Cys Leu Ala Gly Arg Cys Ala Ala Thr Arg Ala Lys Leu 
            420                 425                 430         


Arg Pro Ser Met Asp Glu Val Leu Asn Thr Leu Glu Ser Thr Gln Ala 
        435                 440                 445             


Ser Leu Tyr Phe Ala Glu Asp Pro Pro Thr Ser Leu Lys Ser Phe Arg 
    450                 455                 460                 


Cys Pro Ser Pro Leu Phe Leu Glu Asn Val Pro Ser Ile Pro Val Glu 
465                 470                 475                 480 


Asp Asp Glu Ser Gln Asn Asn Asn Leu Leu Pro Ser Asp Glu Gly Leu 
                485                 490                 495     


Arg Ile Asp Arg Met Thr Gln Lys Thr Pro Phe Glu Cys Ser Gln Ser 
            500                 505                 510         


Glu Val Met Phe Leu Ser Leu Asp Lys Lys Pro Glu Ser Lys Arg Asn 
        515                 520                 525             


Glu Glu Ala Cys Asn Met Pro Ser Ser Ser Cys Glu Glu Ser Trp Phe 
    530                 535                 540                 


Pro Lys Tyr Ile Val Pro Ser Gln Asp Leu Arg Pro Tyr Lys Val Asn 
545                 550                 555                 560 


Ile Asp Pro Ser Ser Glu Ala Pro Gly His Ser Cys Arg Ser Arg Pro 
                565                 570                 575     


Val Glu Ser Ser Cys Ser Ser Lys Phe Ser Trp Asp Glu Tyr Glu Gln 
            580                 585                 590         


Tyr Lys Lys Glu 
        595     


<210>  7223
<211>  535
<212>  PRT
<213>  Homo Sapiens

<400>  7223

Met Ala Gly Asn Cys Gly Ala Arg Gly Ala Leu Ser Ala His Thr Leu 
1               5                   10                  15      


Leu Phe Asp Leu Pro Pro Ala Leu Leu Gly Glu Leu Cys Ala Val Leu 
            20                  25                  30          


Asp Ser Cys Asp Gly Ala Leu Gly Trp Arg Gly Leu Gly Ala Val Leu 
        35                  40                  45              


Ser Pro Ser Glu Lys Ser Tyr Gln Glu Gly Gly Phe Pro Asn Ile Leu 
    50                  55                  60                  


Phe Lys Glu Thr Ala Asn Val Thr Val Asp Asn Val Leu Ile Pro Glu 
65                  70                  75                  80  


His Asn Glu Lys Gly Ile Leu Leu Lys Ser Ser Ile Ser Phe Gln Asn 
                85                  90                  95      


Ile Ile Glu Gly Thr Arg Asn Phe His Lys Asp Phe Leu Ile Gly Glu 
            100                 105                 110         


Gly Glu Ile Phe Glu Val Tyr Arg Val Glu Ile Gln Asn Leu Thr Tyr 
        115                 120                 125             


Ala Val Lys Leu Phe Lys Gln Glu Lys Lys Met Gln Cys Lys Lys His 
    130                 135                 140                 


Trp Lys Arg Phe Leu Ser Glu Leu Glu Val Leu Leu Leu Phe His His 
145                 150                 155                 160 


Pro Asn Ile Leu Glu Leu Ala Ala Tyr Phe Thr Glu Thr Glu Lys Phe 
                165                 170                 175     


Cys Leu Ile Tyr Pro Tyr Met Arg Asn Gly Thr Leu Phe Asp Arg Leu 
            180                 185                 190         


Gln Cys Val Gly Asp Thr Ala Pro Leu Pro Trp His Ile Arg Ile Gly 
        195                 200                 205             


Ile Leu Ile Gly Ile Ser Lys Ala Ile His Tyr Leu His Asn Val Gln 
    210                 215                 220                 


Pro Cys Ser Val Ile Cys Gly Ser Ile Ser Ser Ala Asn Ile Leu Leu 
225                 230                 235                 240 


Asp Asp Gln Phe Gln Pro Lys Leu Thr Asp Phe Ala Met Ala His Phe 
                245                 250                 255     


Arg Ser His Leu Glu His Gln Ser Cys Thr Ile Asn Met Thr Ser Ser 
            260                 265                 270         


Ser Ser Lys His Leu Trp Tyr Met Pro Glu Glu Tyr Ile Arg Gln Gly 
        275                 280                 285             


Lys Leu Ser Ile Lys Thr Asp Val Tyr Ser Phe Gly Ile Val Ile Met 
    290                 295                 300                 


Glu Val Leu Thr Gly Cys Arg Val Val Leu Asp Asp Pro Lys His Ile 
305                 310                 315                 320 


Gln Leu Arg Asp Leu Leu Arg Glu Leu Met Glu Lys Arg Gly Leu Asp 
                325                 330                 335     


Ser Cys Leu Ser Phe Leu Asp Lys Lys Val Pro Pro Cys Pro Arg Asn 
            340                 345                 350         


Phe Ser Ala Lys Leu Phe Cys Leu Ala Gly Arg Cys Ala Ala Thr Arg 
        355                 360                 365             


Ala Lys Leu Arg Pro Ser Met Asp Glu Val Leu Asn Thr Leu Glu Ser 
    370                 375                 380                 


Thr Gln Ala Ser Leu Tyr Phe Ala Glu Asp Pro Pro Thr Ser Leu Lys 
385                 390                 395                 400 


Ser Phe Arg Cys Pro Ser Pro Leu Phe Leu Glu Asn Val Pro Ser Ile 
                405                 410                 415     


Pro Val Glu Asp Asp Glu Ser Gln Asn Asn Asn Leu Leu Pro Ser Asp 
            420                 425                 430         


Glu Gly Leu Arg Ile Asp Arg Met Thr Gln Lys Thr Pro Phe Glu Cys 
        435                 440                 445             


Ser Gln Ser Glu Val Met Phe Leu Ser Leu Asp Lys Lys Pro Glu Ser 
    450                 455                 460                 


Lys Arg Asn Glu Glu Ala Cys Asn Met Pro Ser Ser Ser Cys Glu Glu 
465                 470                 475                 480 


Ser Trp Phe Pro Lys Tyr Ile Val Pro Ser Gln Asp Leu Arg Pro Tyr 
                485                 490                 495     


Lys Val Asn Ile Asp Pro Ser Ser Glu Ala Pro Gly His Ser Cys Arg 
            500                 505                 510         


Ser Arg Pro Val Glu Ser Ser Cys Ser Ser Lys Phe Ser Trp Asp Glu 
        515                 520                 525             


Tyr Glu Gln Tyr Lys Lys Glu 
    530                 535 


<210>  7224
<211>  93
<212>  PRT
<213>  Homo Sapiens

<400>  7224

Met Ala Gly Asn Cys Gly Ala Arg Gly Ala Leu Ser Ala His Thr Leu 
1               5                   10                  15      


Leu Phe Asp Leu Pro Pro Ala Leu Leu Gly Glu Leu Cys Ala Val Leu 
            20                  25                  30          


Asp Ser Cys Asp Gly Ala Leu Gly Trp Arg Gly Leu Val Ser Lys Asn 
        35                  40                  45              


Lys Leu Cys Glu Asn Gly Val Leu Ile Leu Gln Gly Phe Trp His Val 
    50                  55                  60                  


Val Val Cys Lys Tyr Lys Asp Ser Lys Tyr Gly Cys Val Ala Leu Phe 
65                  70                  75                  80  


Glu Lys Thr Pro Ser Glu Thr Tyr Leu His Met Glu Thr 
                85                  90              


<210>  7225
<211>  1257
<212>  PRT
<213>  Homo Sapiens

<400>  7225

Met Ala Ser Cys Ser Phe Thr Arg Asp Gln Ala Thr Arg Arg Leu Arg 
1               5                   10                  15      


Gly Ala Ala Ala Ala Ala Ala Ala Ala Leu Ala Ala Val Val Thr Thr 
            20                  25                  30          


Pro Leu Leu Ser Ser Gly Thr Pro Thr Ala Leu Ile Gly Thr Gly Ser 
        35                  40                  45              


Ser Cys Pro Gly Ala Met Trp Leu Ser Thr Ala Thr Gly Ser Arg Ser 
    50                  55                  60                  


Asp Ser Glu Ser Glu Glu Glu Asp Leu Pro Val Gly Glu Glu Val Cys 
65                  70                  75                  80  


Lys Arg Gly Tyr Leu Arg Lys Gln Lys His Gly His Arg Arg Tyr Phe 
                85                  90                  95      


Val Leu Lys Leu Glu Thr Ala Asp Ala Pro Ala Arg Leu Glu Tyr Tyr 
            100                 105                 110         


Glu Asn Ala Arg Lys Phe Arg His Ser Val Arg Ala Ala Ala Ala Ala 
        115                 120                 125             


Ala Ala Ala Ala Ala Ser Gly Ala Ala Ile Pro Pro Leu Ile Pro Pro 
    130                 135                 140                 


Arg Arg Val Ile Thr Leu Tyr Gln Cys Phe Ser Val Ser Gln Arg Ala 
145                 150                 155                 160 


Asp Ala Arg Tyr Arg His Leu Ile Ala Leu Phe Thr Gln Asp Glu Tyr 
                165                 170                 175     


Phe Ala Met Val Ala Glu Asn Glu Ser Glu Gln Glu Ser Trp Tyr Leu 
            180                 185                 190         


Leu Leu Ser Arg Leu Ile Leu Glu Ser Lys Arg Arg Arg Cys Gly Thr 
        195                 200                 205             


Leu Gly Ala Gln Pro Asp Gly Glu Pro Ala Ala Leu Ala Ala Ala Ala 
    210                 215                 220                 


Ala Ala Glu Pro Pro Phe Tyr Lys Asp Val Trp Gln Val Ile Val Lys 
225                 230                 235                 240 


Pro Arg Gly Leu Gly His Arg Lys Glu Leu Ser Gly Val Phe Arg Leu 
                245                 250                 255     


Cys Leu Thr Asp Glu Glu Val Val Phe Val Arg Leu Asn Thr Glu Val 
            260                 265                 270         


Ala Ser Val Val Val Gln Leu Leu Ser Ile Arg Arg Cys Gly His Ser 
        275                 280                 285             


Glu Gln Tyr Phe Phe Leu Glu Val Gly Arg Ser Thr Val Ile Gly Pro 
    290                 295                 300                 


Gly Glu Leu Trp Met Gln Val Asp Asp Cys Val Val Ala Gln Asn Met 
305                 310                 315                 320 


His Glu Leu Phe Leu Glu Lys Met Arg Ala Leu Cys Ala Asp Glu Tyr 
                325                 330                 335     


Arg Ala Arg Cys Arg Ser Tyr Ser Ile Ser Ile Gly Ala His Leu Leu 
            340                 345                 350         


Thr Leu Leu Ser Ala Arg Arg His Leu Gly Leu Val Pro Leu Glu Pro 
        355                 360                 365             


Gly Gly Trp Leu Arg Arg Ser Arg Phe Glu Gln Phe Cys His Leu Arg 
    370                 375                 380                 


Ala Ile Gly Asp Gly Glu Asp Glu Met Leu Phe Thr Arg Arg Phe Val 
385                 390                 395                 400 


Thr Pro Ser Glu Pro Val Ala His Ser Arg Arg Gly Arg Leu His Leu 
                405                 410                 415     


Pro Arg Gly Arg Arg Ser Arg Arg Ala Val Ser Val Pro Ala Ser Phe 
            420                 425                 430         


Phe Arg Arg Leu Ala Pro Ser Pro Ala Arg Pro Arg His Pro Ala Glu 
        435                 440                 445             


Ala Pro Asn Asn Gly Ala Arg Leu Ser Ser Glu Val Ser Gly Ser Gly 
    450                 455                 460                 


Ser Gly Asn Phe Gly Glu Glu Gly Asn Pro Gln Gly Lys Glu Asp Gln 
465                 470                 475                 480 


Glu Gly Ser Gly Gly Asp Tyr Met Pro Met Asn Asn Trp Gly Ser Gly 
                485                 490                 495     


Asn Gly Arg Gly Ser Gly Gly Gly Gln Gly Ser Asn Gly Gln Gly Ser 
            500                 505                 510         


Ser Ser His Ser Ser Gly Gly Asn Gln Cys Ser Gly Glu Gly Gln Gly 
        515                 520                 525             


Ser Arg Gly Gly Gln Gly Ser Asn Gly Gln Gly Ser Gly Gly Asn Gln 
    530                 535                 540                 


Cys Ser Arg Asp Gly Gln Gly Thr Ala Gly Gly His Gly Ser Gly Gly 
545                 550                 555                 560 


Gly Gln Arg Pro Gly Gly Gly His Gly Ser Gly Gly Gly Gln Gly Pro 
                565                 570                 575     


Gly Asp Gly His Gly Ser Gly Gly Gly Lys Asn Ser Gly Gly Gly Lys 
            580                 585                 590         


Gly Ser Gly Ser Gly Lys Gly Ser Asp Gly Asp Gly Glu Arg Gly Lys 
        595                 600                 605             


Ser Leu Lys Lys Arg Ser Tyr Phe Gly Lys Leu Thr Gln Ser Lys Gln 
    610                 615                 620                 


Gln Gln Met Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala 
625                 630                 635                 640 


Gly Gly Thr Gly Gly Lys Gly Lys Ser Gly Gly Arg Phe Arg Leu Tyr 
                645                 650                 655     


Phe Cys Val Asp Arg Gly Ala Thr Lys Glu Cys Lys Glu Ala Lys Glu 
            660                 665                 670         


Val Lys Asp Ala Glu Ile Pro Glu Gly Ala Ala Arg Gly Pro His Arg 
        675                 680                 685             


Ala Arg Ala Phe Asp Glu Asp Glu Asp Asp Pro Tyr Val Pro Met Arg 
    690                 695                 700                 


Pro Gly Val Ala Thr Pro Leu Val Ser Ser Ser Asp Tyr Met Pro Met 
705                 710                 715                 720 


Ala Pro Gln Asn Val Ser Ala Ser Lys Lys Arg His Ser Arg Ser Pro 
                725                 730                 735     


Phe Glu Asp Ser Arg Gly Tyr Met Met Met Phe Pro Arg Val Ser Pro 
            740                 745                 750         


Pro Pro Ala Pro Ser Pro Pro Lys Ala Pro Asp Thr Asn Lys Glu Asp 
        755                 760                 765             


Asp Ser Lys Asp Asn Asp Ser Glu Ser Asp Tyr Met Phe Met Ala Pro 
    770                 775                 780                 


Gly Ala Gly Ala Ile Pro Lys Asn Pro Arg Asn Pro Gln Gly Gly Ser 
785                 790                 795                 800 


Ser Ser Lys Ser Trp Ser Ser Tyr Phe Ser Leu Pro Asn Pro Phe Arg 
                805                 810                 815     


Ser Ser Pro Leu Gly Gln Asn Asp Asn Ser Glu Tyr Val Pro Met Leu 
            820                 825                 830         


Pro Gly Lys Phe Leu Gly Arg Gly Leu Asp Lys Glu Val Ser Tyr Asn 
        835                 840                 845             


Trp Asp Pro Lys Asp Ala Ala Ser Lys Pro Ser Gly Glu Gly Ser Phe 
    850                 855                 860                 


Ser Lys Pro Gly Asp Gly Gly Ser Pro Ser Lys Pro Ser Asp His Glu 
865                 870                 875                 880 


Pro Pro Lys Asn Lys Ala Lys Arg Pro Asn Arg Leu Ser Phe Ile Thr 
                885                 890                 895     


Lys Gly Tyr Lys Ile Lys Pro Lys Pro Gln Lys Pro Thr His Glu Gln 
            900                 905                 910         


Arg Glu Ala Asp Ser Ser Ser Asp Tyr Val Asn Met Asp Phe Thr Lys 
        915                 920                 925             


Arg Glu Ser Asn Thr Pro Ala Pro Ser Thr Gln Gly Leu Pro Asp Ser 
    930                 935                 940                 


Trp Gly Ile Ile Ala Glu Pro Arg Gln Ser Ala Phe Ser Asn Tyr Val 
945                 950                 955                 960 


Asn Val Glu Phe Gly Val Pro Phe Pro Asn Pro Ala Asn Asp Leu Ser 
                965                 970                 975     


Asp Leu Leu Arg Ala Ile Pro Arg Ala Asn Pro Leu Ser Leu Asp Ser 
            980                 985                 990         


Ala Arg Trp Pro Leu Pro Pro Leu  Pro Leu Ser Ala Thr  Gly Ser Asn 
        995                 1000                 1005             


Ala Ile  Glu Glu Glu Gly Asp  Tyr Ile Glu Val Ile  Phe Asn Ser 
    1010                 1015                 1020             


Ala Met  Thr Pro Ala Met Ala  Leu Ala Asp Ser Ala  Ile Arg Tyr 
    1025                 1030                 1035             


Asp Ala  Glu Thr Gly Arg Ile  Tyr Val Val Asp Pro  Phe Ser Glu 
    1040                 1045                 1050             


Cys Cys  Met Asp Ile Ser Leu  Ser Pro Ser Arg Cys  Ser Glu Pro 
    1055                 1060                 1065             


Pro Pro  Val Ala Arg Leu Leu  Gln Glu Glu Glu Gln  Glu Arg Arg 
    1070                 1075                 1080             


Arg Pro  Gln Ser Arg Ser Gln  Ser Phe Phe Ala Ala  Ala Arg Ala 
    1085                 1090                 1095             


Ala Val  Ser Ala Phe Pro Thr  Asp Ser Leu Glu Arg  Asp Leu Ser 
    1100                 1105                 1110             


Pro Ser  Ser Ala Pro Ala Val  Ala Ser Ala Ala Glu  Pro Thr Leu 
    1115                 1120                 1125             


Ala Leu  Ser Gln Val Val Ala  Ala Ala Ser Ala Leu  Ala Ala Ala 
    1130                 1135                 1140             


Pro Gly  Ile Gly Ala Ala Ala  Ala Ala Ala Gly Phe  Asp Ser Ala 
    1145                 1150                 1155             


Ser Ala  Arg Trp Phe Gln Pro  Val Ala Asn Ala Ala  Asp Ala Glu 
    1160                 1165                 1170             


Ala Val  Arg Gly Ala Gln Asp  Val Ala Gly Gly Ser  Asn Pro Gly 
    1175                 1180                 1185             


Ala His  Asn Pro Ser Ala Asn  Leu Ala Arg Gly Asp  Asn Gln Ala 
    1190                 1195                 1200             


Gly Gly  Ala Ala Ala Ala Ala  Ala Ala Pro Glu Pro  Pro Pro Arg 
    1205                 1210                 1215             


Ser Arg  Arg Val Pro Arg Pro  Pro Glu Arg Glu Asp  Ser Asp Asn 
    1220                 1225                 1230             


Asp Asp  Asp Thr His Val Arg  Met Asp Phe Ala Arg  Arg Asp Asn 
    1235                 1240                 1245             


Gln Phe  Asp Ser Pro Lys Arg  Gly Arg 
    1250                 1255         


<210>  7226
<211>  147
<212>  PRT
<213>  Homo Sapiens

<400>  7226

Met Gln Glu Leu His Leu Leu Trp Trp Ala Leu Leu Leu Gly Leu Ala 
1               5                   10                  15      


Gln Ala Cys Pro Glu Pro Cys Asp Cys Gly Glu Lys Tyr Gly Phe Gln 
            20                  25                  30          


Ile Ala Asp Cys Ala Tyr Arg Asp Leu Glu Ser Val Pro Pro Gly Phe 
        35                  40                  45              


Pro Ala Asn Val Thr Thr Leu Ser Leu Ser Ala Asn Arg Leu Pro Gly 
    50                  55                  60                  


Leu Pro Glu Gly Ala Phe Arg Glu Val Pro Leu Leu Gln Ser Leu Trp 
65                  70                  75                  80  


Leu Ala His Asn Glu Ile Arg Thr Val Ala Ala Gly Ala Leu Ala Ser 
                85                  90                  95      


Leu Ser His Leu Lys Ser Leu Asp Leu Ser His Asn Leu Ile Ser Asp 
            100                 105                 110         


Phe Ala Trp Ser Asp Leu His Asn Leu Ser Ala Leu Gln Leu Leu Lys 
        115                 120                 125             


Met Asp Ser Asn Glu Leu Thr Phe Ile Pro Arg Asp Ala Phe Arg Ser 
    130                 135                 140                 


Leu Arg Ala 
145         


<210>  7227
<211>  183
<212>  PRT
<213>  Homo Sapiens

<400>  7227

Met Gln Glu Leu His Leu Leu Trp Trp Ala Leu Leu Leu Gly Leu Ala 
1               5                   10                  15      


Gln Ala Cys Pro Glu Pro Cys Asp Cys Gly Glu Lys Tyr Gly Phe Gln 
            20                  25                  30          


Ile Ala Asp Cys Ala Tyr Arg Asp Leu Glu Ser Val Pro Pro Gly Phe 
        35                  40                  45              


Pro Ala Asn Val Thr Thr Leu Ser Leu Ser Ala Asn Arg Leu Pro Gly 
    50                  55                  60                  


Leu Pro Glu Gly Ala Phe Arg Glu Val Pro Leu Leu Gln Ser Leu Trp 
65                  70                  75                  80  


Leu Ala His Asn Glu Ile Arg Thr Val Ala Ala Gly Ala Leu Ala Ser 
                85                  90                  95      


Leu Ser His Leu Lys Ser Leu Asp Leu Ser His Asn Leu Ile Ser Asp 
            100                 105                 110         


Phe Ala Trp Ser Asp Leu His Asn Leu Ser Ala Leu Gln Leu Leu Lys 
        115                 120                 125             


Met Asp Ser Asn Glu Leu Thr Phe Ile Pro Arg Asp Ala Phe Arg Ser 
    130                 135                 140                 


Leu Arg Ala Leu Arg Ser Leu Gln Leu Asn His Asn Arg Leu His Thr 
145                 150                 155                 160 


Leu Ala Glu Gly Thr Phe Thr Pro Leu Thr Ala Leu Ser His Leu Gln 
                165                 170                 175     


Ile Asn Glu Asn Pro Phe Asp 
            180             


<210>  7228
<211>  428
<212>  PRT
<213>  Homo Sapiens

<400>  7228

Met Gln Glu Leu His Leu Leu Trp Trp Ala Leu Leu Leu Gly Leu Ala 
1               5                   10                  15      


Gln Ala Cys Pro Glu Pro Cys Asp Cys Gly Glu Lys Tyr Gly Phe Gln 
            20                  25                  30          


Ile Ala Asp Cys Ala Tyr Arg Asp Leu Glu Ser Val Pro Pro Gly Phe 
        35                  40                  45              


Pro Ala Asn Val Thr Thr Leu Ser Leu Ser Ala Asn Arg Leu Pro Gly 
    50                  55                  60                  


Leu Pro Glu Gly Ala Phe Arg Glu Val Pro Leu Leu Gln Ser Leu Trp 
65                  70                  75                  80  


Leu Ala His Asn Glu Ile Arg Thr Val Ala Ala Gly Ala Leu Ala Ser 
                85                  90                  95      


Leu Ser His Leu Lys Ser Leu Asp Leu Ser His Asn Leu Ile Ser Asp 
            100                 105                 110         


Phe Ala Trp Ser Asp Leu His Asn Leu Ser Ala Leu Gln Leu Leu Lys 
        115                 120                 125             


Met Asp Ser Asn Glu Leu Thr Phe Ile Pro Arg Asp Ala Phe Arg Ser 
    130                 135                 140                 


Leu Arg Ala Leu Arg Ser Leu Gln Leu Asn His Asn Arg Leu His Thr 
145                 150                 155                 160 


Leu Ala Glu Gly Thr Phe Thr Pro Leu Thr Ala Leu Ser His Leu Gln 
                165                 170                 175     


Ile Asn Glu Asn Pro Phe Asp Cys Thr Cys Gly Ile Val Trp Leu Lys 
            180                 185                 190         


Thr Trp Ala Leu Thr Thr Ala Val Ser Ile Pro Glu Gln Asp Asn Ile 
        195                 200                 205             


Ala Cys Thr Ser Pro His Val Leu Lys Gly Thr Pro Leu Ser Arg Leu 
    210                 215                 220                 


Pro Pro Leu Pro Cys Ser Ala Pro Ser Val Gln Leu Ser Tyr Gln Pro 
225                 230                 235                 240 


Ser Gln Asp Gly Ala Glu Leu Arg Pro Gly Phe Val Leu Ala Leu His 
                245                 250                 255     


Cys Asp Val Asp Gly Gln Pro Ala Pro Gln Leu His Trp His Ile Gln 
            260                 265                 270         


Ile Pro Ser Gly Ile Val Glu Ile Thr Ser Pro Asn Val Gly Thr Asp 
        275                 280                 285             


Gly Arg Ala Leu Pro Gly Thr Pro Val Ala Ser Ser Gln Pro Arg Phe 
    290                 295                 300                 


Gln Ala Phe Ala Asn Gly Ser Leu Leu Ile Pro Asp Phe Gly Lys Leu 
305                 310                 315                 320 


Glu Glu Gly Thr Tyr Ser Cys Leu Ala Thr Asn Glu Leu Gly Ser Ala 
                325                 330                 335     


Glu Ser Ser Val Asp Val Ala Leu Ala Thr Pro Gly Glu Gly Gly Glu 
            340                 345                 350         


Asp Thr Leu Gly Arg Arg Phe His Gly Lys Ala Val Glu Gly Lys Gly 
        355                 360                 365             


Cys Tyr Thr Val Asp Asn Glu Val Gln Pro Ser Gly Pro Glu Asp Asn 
    370                 375                 380                 


Val Val Ile Ile Tyr Leu Ser Arg Ala Gly Asn Pro Glu Ala Ala Val 
385                 390                 395                 400 


Ala Glu Gly Val Pro Gly Gln Leu Pro Pro Gly Leu Leu Leu Leu Gly 
                405                 410                 415     


Gln Ser Leu Leu Leu Phe Phe Phe Leu Thr Ser Phe 
            420                 425             


<210>  7229
<211>  428
<212>  PRT
<213>  Homo Sapiens

<400>  7229

Met Gln Glu Leu His Leu Leu Trp Trp Ala Leu Leu Leu Gly Leu Ala 
1               5                   10                  15      


Gln Ala Cys Pro Glu Pro Cys Asp Cys Gly Glu Lys Tyr Gly Phe Gln 
            20                  25                  30          


Ile Ala Asp Cys Ala Tyr Arg Asp Leu Glu Ser Val Pro Pro Gly Phe 
        35                  40                  45              


Pro Ala Asn Val Thr Thr Leu Ser Leu Ser Ala Asn Arg Leu Pro Gly 
    50                  55                  60                  


Leu Pro Glu Gly Ala Phe Arg Glu Val Pro Leu Leu Gln Ser Leu Trp 
65                  70                  75                  80  


Leu Ala His Asn Glu Ile Arg Thr Val Ala Ala Gly Ala Leu Ala Ser 
                85                  90                  95      


Leu Ser His Leu Lys Ser Leu Asp Leu Ser His Asn Leu Ile Ser Asp 
            100                 105                 110         


Phe Ala Trp Ser Asp Leu His Asn Leu Ser Ala Leu Gln Leu Leu Lys 
        115                 120                 125             


Met Asp Ser Asn Glu Leu Thr Phe Ile Pro Arg Asp Ala Phe Arg Ser 
    130                 135                 140                 


Leu Arg Ala Leu Arg Ser Leu Gln Leu Asn His Asn Arg Leu His Thr 
145                 150                 155                 160 


Leu Ala Glu Gly Thr Phe Thr Pro Leu Thr Ala Leu Ser His Leu Gln 
                165                 170                 175     


Ile Asn Glu Asn Pro Phe Asp Cys Thr Cys Gly Ile Val Trp Leu Lys 
            180                 185                 190         


Thr Trp Ala Leu Thr Thr Ala Val Ser Ile Pro Glu Gln Asp Asn Ile 
        195                 200                 205             


Ala Cys Thr Ser Pro His Val Leu Lys Gly Thr Pro Leu Ser Arg Leu 
    210                 215                 220                 


Pro Pro Leu Pro Cys Ser Ala Pro Ser Val Gln Leu Ser Tyr Gln Pro 
225                 230                 235                 240 


Ser Gln Asp Gly Ala Glu Leu Arg Pro Gly Phe Val Leu Ala Leu His 
                245                 250                 255     


Cys Asp Val Asp Gly Gln Pro Ala Pro Gln Leu His Trp His Ile Gln 
            260                 265                 270         


Ile Pro Ser Gly Ile Val Glu Ile Thr Ser Pro Asn Val Gly Thr Asp 
        275                 280                 285             


Gly Arg Ala Leu Pro Gly Thr Pro Val Ala Ser Ser Gln Pro Arg Phe 
    290                 295                 300                 


Gln Ala Phe Ala Asn Gly Ser Leu Leu Ile Pro Asp Phe Gly Lys Leu 
305                 310                 315                 320 


Glu Glu Gly Thr Tyr Ser Cys Leu Ala Thr Asn Glu Leu Gly Ser Ala 
                325                 330                 335     


Glu Ser Ser Val Asp Val Ala Leu Ala Thr Pro Gly Glu Gly Gly Glu 
            340                 345                 350         


Asp Thr Leu Gly Arg Arg Phe His Gly Lys Ala Val Glu Gly Lys Gly 
        355                 360                 365             


Cys Tyr Thr Val Asp Asn Glu Val Gln Pro Ser Gly Pro Glu Asp Asn 
    370                 375                 380                 


Val Val Ile Ile Tyr Leu Ser Arg Ala Gly Asn Pro Glu Ala Ala Val 
385                 390                 395                 400 


Ala Glu Gly Val Pro Gly Gln Leu Pro Pro Gly Leu Leu Leu Leu Gly 
                405                 410                 415     


Gln Ser Leu Leu Leu Phe Phe Phe Leu Thr Ser Phe 
            420                 425             


<210>  7230
<211>  5
<212>  PRT
<213>  Homo Sapiens

<400>  7230

Met Phe Pro Leu Arg 
1               5   


<210>  7231
<211>  89
<212>  PRT
<213>  Homo Sapiens

<400>  7231

Met Phe Pro Leu Arg Ala Leu Trp Leu Val Trp Ala Leu Leu Gly Val 
1               5                   10                  15      


Ala Gly Ser Cys Pro Glu Pro Cys Ala Cys Val Asp Lys Tyr Ala His 
            20                  25                  30          


Gln Phe Ala Asp Cys Ala Tyr Lys Glu Leu Arg Glu Val Pro Glu Gly 
        35                  40                  45              


Leu Pro Ala Asn Val Thr Thr Leu Ser Leu Ser Ala Asn Lys Ile Thr 
    50                  55                  60                  


Val Leu Arg Arg Gly Ala Phe Ala Asp Val Thr Gln Val Thr Ser Leu 
65                  70                  75                  80  


Trp Leu Ala His Asn Glu Val Arg Thr 
                85                  


<210>  7232
<211>  114
<212>  PRT
<213>  Homo Sapiens

<400>  7232

Met Phe Pro Leu Arg Ala Leu Trp Leu Val Trp Ala Leu Leu Gly Val 
1               5                   10                  15      


Ala Gly Ser Cys Pro Glu Pro Cys Ala Cys Val Asp Lys Tyr Ala His 
            20                  25                  30          


Gln Phe Ala Asp Cys Ala Tyr Lys Glu Leu Arg Glu Val Pro Glu Gly 
        35                  40                  45              


Leu Pro Ala Asn Val Thr Thr Leu Ser Leu Ser Ala Asn Lys Ile Thr 
    50                  55                  60                  


Val Leu Arg Arg Gly Ala Phe Ala Asp Val Thr Gln Val Thr Ser Leu 
65                  70                  75                  80  


Trp Leu Ala His Asn Glu Val Arg Thr Val Glu Pro Gly Ala Leu Ala 
                85                  90                  95      


Val Leu Ser Gln Leu Lys Asn Leu Asp Leu Ser His Asn Phe Ile Ser 
            100                 105                 110         


Ser Phe 
        


<210>  7233
<211>  138
<212>  PRT
<213>  Homo Sapiens

<400>  7233

Met Phe Pro Leu Arg Ala Leu Trp Leu Val Trp Ala Leu Leu Gly Val 
1               5                   10                  15      


Ala Gly Ser Cys Pro Glu Pro Cys Ala Cys Val Asp Lys Tyr Ala His 
            20                  25                  30          


Gln Phe Ala Asp Cys Ala Tyr Lys Glu Leu Arg Glu Val Pro Glu Gly 
        35                  40                  45              


Leu Pro Ala Asn Val Thr Thr Leu Ser Leu Ser Ala Asn Lys Ile Thr 
    50                  55                  60                  


Val Leu Arg Arg Gly Ala Phe Ala Asp Val Thr Gln Val Thr Ser Leu 
65                  70                  75                  80  


Trp Leu Ala His Asn Glu Val Arg Thr Val Glu Pro Gly Ala Leu Ala 
                85                  90                  95      


Val Leu Ser Gln Leu Lys Asn Leu Asp Leu Ser His Asn Phe Ile Ser 
            100                 105                 110         


Ser Phe Pro Trp Ser Asp Leu Arg Asn Leu Ser Ala Leu Gln Leu Leu 
        115                 120                 125             


Lys Met Asn His Asn Arg Leu Gly Ser Leu 
    130                 135             


<210>  7234
<211>  334
<212>  PRT
<213>  Homo Sapiens

<400>  7234

Met Phe Pro Leu Arg Ala Leu Trp Leu Val Trp Ala Leu Leu Gly Val 
1               5                   10                  15      


Ala Gly Ser Cys Pro Glu Pro Cys Ala Cys Val Asp Lys Tyr Ala His 
            20                  25                  30          


Gln Phe Ala Asp Cys Ala Tyr Lys Glu Leu Arg Glu Val Pro Glu Gly 
        35                  40                  45              


Leu Pro Ala Asn Val Thr Thr Leu Ser Leu Ser Ala Asn Lys Ile Thr 
    50                  55                  60                  


Val Leu Arg Arg Gly Ala Phe Ala Asp Val Thr Gln Val Thr Ser Leu 
65                  70                  75                  80  


Trp Leu Ala His Asn Glu Val Arg Thr Val Glu Pro Gly Ala Leu Ala 
                85                  90                  95      


Val Leu Ser Gln Leu Lys Asn Leu Asp Leu Ser His Asn Phe Ile Ser 
            100                 105                 110         


Ser Phe Pro Trp Ser Asp Leu Arg Asn Leu Ser Ala Leu Gln Leu Leu 
        115                 120                 125             


Lys Met Asn His Asn Arg Leu Gly Ser Leu Pro Arg Asp Ala Leu Gly 
    130                 135                 140                 


Ala Leu Pro Asp Leu Arg Ser Leu Arg Ile Asn Asn Asn Arg Leu Ala 
145                 150                 155                 160 


Gly Glu Ala Cys His Val Gln Val Val Phe Ser Thr Lys Lys Glu Leu 
                165                 170                 175     


Pro Ser Leu Leu Val Ile Val Ala Val Ser Val Phe Leu Leu Val Leu 
            180                 185                 190         


Ala Thr Val Pro Leu Leu Gly Ala Ala Cys Cys His Leu Leu Ala Lys 
        195                 200                 205             


His Pro Gly Lys Pro Tyr Arg Leu Ile Leu Arg Pro Gln Ala Pro Asp 
    210                 215                 220                 


Pro Met Glu Lys Arg Ile Ala Ala Asp Phe Asp Pro Arg Ala Ser Tyr 
225                 230                 235                 240 


Leu Glu Ser Glu Lys Ser Tyr Pro Ala Gly Gly Glu Ala Gly Gly Glu 
                245                 250                 255     


Glu Pro Glu Asp Val Gln Gly Glu Gly Leu Asp Glu Asp Ala Glu Gln 
            260                 265                 270         


Gly Asp Pro Ser Gly Asp Leu Gln Arg Glu Glu Ser Leu Ala Ala Cys 
        275                 280                 285             


Ser Leu Val Glu Ser Gln Ser Lys Ala Asn Gln Glu Glu Phe Glu Ala 
    290                 295                 300                 


Gly Ser Glu Tyr Ser Asp Arg Leu Pro Leu Gly Ala Glu Ala Val Asn 
305                 310                 315                 320 


Ile Ala Gln Glu Ile Asn Gly Asn Tyr Arg Gln Thr Ala Gly 
                325                 330                 


<210>  7235
<211>  745
<212>  PRT
<213>  Homo Sapiens

<400>  7235

Met Phe Pro Leu Arg Ala Leu Trp Leu Val Trp Ala Leu Leu Gly Val 
1               5                   10                  15      


Ala Gly Ser Cys Pro Glu Pro Cys Ala Cys Val Asp Lys Tyr Ala His 
            20                  25                  30          


Gln Phe Ala Asp Cys Ala Tyr Lys Glu Leu Arg Glu Val Pro Glu Gly 
        35                  40                  45              


Leu Pro Ala Asn Val Thr Thr Leu Ser Leu Ser Ala Asn Lys Ile Thr 
    50                  55                  60                  


Val Leu Arg Arg Gly Ala Phe Ala Asp Val Thr Gln Val Thr Ser Leu 
65                  70                  75                  80  


Trp Leu Ala His Asn Glu Val Arg Thr Val Glu Pro Gly Ala Leu Ala 
                85                  90                  95      


Val Leu Ser Gln Leu Lys Asn Leu Asp Leu Ser His Asn Phe Ile Ser 
            100                 105                 110         


Ser Phe Pro Trp Ser Asp Leu Arg Asn Leu Ser Ala Leu Gln Leu Leu 
        115                 120                 125             


Lys Met Asn His Asn Arg Leu Gly Ser Leu Pro Arg Asp Ala Leu Gly 
    130                 135                 140                 


Ala Leu Pro Asp Leu Arg Ser Leu Arg Ile Asn Asn Asn Arg Leu Arg 
145                 150                 155                 160 


Thr Leu Ala Pro Gly Thr Phe Asp Ala Leu Ser Ala Leu Ser His Leu 
                165                 170                 175     


Gln Leu Tyr His Asn Pro Phe His Cys Gly Cys Gly Leu Val Trp Leu 
            180                 185                 190         


Gln Ala Trp Ala Ala Ser Thr Arg Val Ser Leu Pro Glu Pro Asp Ser 
        195                 200                 205             


Ile Ala Cys Ala Ser Pro Pro Ala Leu Gln Gly Val Pro Val Tyr Arg 
    210                 215                 220                 


Leu Pro Ala Leu Pro Cys Ala Pro Pro Ser Val His Leu Ser Ala Glu 
225                 230                 235                 240 


Pro Pro Leu Glu Ala Pro Gly Thr Pro Leu Arg Ala Gly Leu Ala Phe 
                245                 250                 255     


Val Leu His Cys Ile Ala Asp Gly His Pro Thr Pro Arg Leu Gln Trp 
            260                 265                 270         


Gln Leu Gln Ile Pro Gly Gly Thr Val Val Leu Glu Pro Pro Val Leu 
        275                 280                 285             


Ser Gly Glu Asp Asp Gly Val Gly Ala Glu Glu Gly Glu Gly Glu Gly 
    290                 295                 300                 


Asp Gly Asp Leu Leu Thr Gln Thr Gln Ala Gln Thr Pro Thr Pro Ala 
305                 310                 315                 320 


Pro Ala Trp Pro Ala Pro Pro Ala Thr Pro Arg Phe Leu Ala Leu Ala 
                325                 330                 335     


Asn Gly Ser Leu Leu Val Pro Leu Leu Ser Ala Lys Glu Ala Gly Val 
            340                 345                 350         


Tyr Thr Cys Arg Ala His Asn Glu Leu Gly Ala Asn Ser Thr Ser Ile 
        355                 360                 365             


Arg Val Ala Val Ala Ala Thr Gly Pro Pro Lys His Ala Pro Gly Ala 
    370                 375                 380                 


Gly Gly Glu Pro Asp Gly Gln Ala Pro Thr Ser Glu Arg Lys Ser Thr 
385                 390                 395                 400 


Ala Lys Gly Arg Gly Asn Ser Val Leu Pro Ser Lys Pro Glu Gly Lys 
                405                 410                 415     


Ile Lys Gly Gln Gly Leu Ala Lys Val Ser Ile Leu Gly Glu Thr Glu 
            420                 425                 430         


Thr Glu Pro Glu Glu Asp Thr Ser Glu Gly Glu Glu Ala Glu Asp Gln 
        435                 440                 445             


Ile Leu Ala Asp Pro Ala Glu Glu Gln Arg Cys Gly Asn Gly Asp Pro 
    450                 455                 460                 


Ser Arg Tyr Val Ser Asn His Ala Phe Asn Gln Ser Ala Glu Leu Lys 
465                 470                 475                 480 


Pro His Val Phe Glu Leu Gly Val Ile Ala Leu Asp Val Ala Glu Arg 
                485                 490                 495     


Glu Ala Arg Val Gln Leu Thr Pro Leu Ala Ala Arg Trp Gly Pro Gly 
            500                 505                 510         


Pro Gly Gly Ala Gly Gly Ala Pro Arg Pro Gly Arg Arg Pro Leu Arg 
        515                 520                 525             


Leu Leu Tyr Leu Cys Pro Ala Gly Gly Gly Ala Ala Val Gln Trp Ser 
    530                 535                 540                 


Arg Val Glu Glu Gly Val Asn Ala Tyr Trp Phe Arg Gly Leu Arg Pro 
545                 550                 555                 560 


Gly Thr Asn Tyr Ser Val Cys Leu Ala Leu Ala Gly Glu Ala Cys His 
                565                 570                 575     


Val Gln Val Val Phe Ser Thr Lys Lys Glu Leu Pro Ser Leu Leu Val 
            580                 585                 590         


Ile Val Ala Val Ser Val Phe Leu Leu Val Leu Ala Thr Val Pro Leu 
        595                 600                 605             


Leu Gly Ala Ala Cys Cys His Leu Leu Ala Lys His Pro Gly Lys Pro 
    610                 615                 620                 


Tyr Arg Leu Ile Leu Arg Pro Gln Ala Pro Asp Pro Met Glu Lys Arg 
625                 630                 635                 640 


Ile Ala Ala Asp Phe Asp Pro Arg Ala Ser Tyr Leu Glu Ser Glu Lys 
                645                 650                 655     


Ser Tyr Pro Ala Gly Gly Glu Ala Gly Gly Glu Glu Pro Glu Asp Val 
            660                 665                 670         


Gln Gly Glu Gly Leu Asp Glu Asp Ala Glu Gln Gly Asp Pro Ser Gly 
        675                 680                 685             


Asp Leu Gln Arg Glu Glu Ser Leu Ala Ala Cys Ser Leu Val Glu Ser 
    690                 695                 700                 


Gln Ser Lys Ala Asn Gln Glu Glu Phe Glu Ala Gly Ser Glu Tyr Ser 
705                 710                 715                 720 


Asp Arg Leu Pro Leu Gly Ala Glu Ala Val Asn Ile Ala Gln Glu Ile 
                725                 730                 735     


Asn Gly Asn Tyr Arg Gln Thr Ala Gly 
            740                 745 


<210>  7236
<211>  745
<212>  PRT
<213>  Homo Sapiens

<400>  7236

Met Phe Pro Leu Arg Ala Leu Trp Leu Val Trp Ala Leu Leu Gly Val 
1               5                   10                  15      


Ala Gly Ser Cys Pro Glu Pro Cys Ala Cys Val Asp Lys Tyr Ala His 
            20                  25                  30          


Gln Phe Ala Asp Cys Ala Tyr Lys Glu Leu Arg Glu Val Pro Glu Gly 
        35                  40                  45              


Leu Pro Ala Asn Val Thr Thr Leu Ser Leu Ser Ala Asn Lys Ile Thr 
    50                  55                  60                  


Val Leu Arg Arg Gly Ala Phe Ala Asp Val Thr Gln Val Thr Ser Leu 
65                  70                  75                  80  


Trp Leu Ala His Asn Glu Val Arg Thr Val Glu Pro Gly Ala Leu Ala 
                85                  90                  95      


Val Leu Ser Gln Leu Lys Asn Leu Asp Leu Ser His Asn Phe Ile Ser 
            100                 105                 110         


Ser Phe Pro Trp Ser Asp Leu Arg Asn Leu Ser Ala Leu Gln Leu Leu 
        115                 120                 125             


Lys Met Asn His Asn Arg Leu Gly Ser Leu Pro Arg Asp Ala Leu Gly 
    130                 135                 140                 


Ala Leu Pro Asp Leu Arg Ser Leu Arg Ile Asn Asn Asn Arg Leu Arg 
145                 150                 155                 160 


Thr Leu Ala Pro Gly Thr Phe Asp Ala Leu Ser Ala Leu Ser His Leu 
                165                 170                 175     


Gln Leu Tyr His Asn Pro Phe His Cys Gly Cys Gly Leu Val Trp Leu 
            180                 185                 190         


Gln Ala Trp Ala Ala Ser Thr Arg Val Ser Leu Pro Glu Pro Asp Ser 
        195                 200                 205             


Ile Ala Cys Ala Ser Pro Pro Ala Leu Gln Gly Val Pro Val Tyr Arg 
    210                 215                 220                 


Leu Pro Ala Leu Pro Cys Ala Pro Pro Ser Val His Leu Ser Ala Glu 
225                 230                 235                 240 


Pro Pro Leu Glu Ala Pro Gly Thr Pro Leu Arg Ala Gly Leu Ala Phe 
                245                 250                 255     


Val Leu His Cys Ile Ala Asp Gly His Pro Thr Pro Arg Leu Gln Trp 
            260                 265                 270         


Gln Leu Gln Ile Pro Gly Gly Thr Val Val Leu Glu Pro Pro Val Leu 
        275                 280                 285             


Ser Gly Glu Asp Asp Gly Val Gly Ala Glu Glu Gly Glu Gly Glu Gly 
    290                 295                 300                 


Asp Gly Asp Leu Leu Thr Gln Thr Gln Ala Gln Thr Pro Thr Pro Ala 
305                 310                 315                 320 


Pro Ala Trp Pro Ala Pro Pro Ala Thr Pro Arg Phe Leu Ala Leu Ala 
                325                 330                 335     


Asn Gly Ser Leu Leu Val Pro Leu Leu Ser Ala Lys Glu Ala Gly Val 
            340                 345                 350         


Tyr Thr Cys Arg Ala His Asn Glu Leu Gly Ala Asn Ser Thr Ser Ile 
        355                 360                 365             


Arg Val Ala Val Ala Ala Thr Gly Pro Pro Lys His Ala Pro Gly Ala 
    370                 375                 380                 


Gly Gly Glu Pro Asp Gly Gln Ala Pro Thr Ser Glu Arg Lys Ser Thr 
385                 390                 395                 400 


Ala Lys Gly Arg Gly Asn Ser Val Leu Pro Ser Lys Pro Glu Gly Lys 
                405                 410                 415     


Ile Lys Gly Gln Gly Leu Ala Lys Val Ser Ile Leu Gly Glu Thr Glu 
            420                 425                 430         


Thr Glu Pro Glu Glu Asp Thr Ser Glu Gly Glu Glu Ala Glu Asp Gln 
        435                 440                 445             


Ile Leu Ala Asp Pro Ala Glu Glu Gln Arg Cys Gly Asn Gly Asp Pro 
    450                 455                 460                 


Ser Arg Tyr Val Ser Asn His Ala Phe Asn Gln Ser Ala Glu Leu Lys 
465                 470                 475                 480 


Pro His Val Phe Glu Leu Gly Val Ile Ala Leu Asp Val Ala Glu Arg 
                485                 490                 495     


Glu Ala Arg Val Gln Leu Thr Pro Leu Ala Ala Arg Trp Gly Pro Gly 
            500                 505                 510         


Pro Gly Gly Ala Gly Gly Ala Pro Arg Pro Gly Arg Arg Pro Leu Arg 
        515                 520                 525             


Leu Leu Tyr Leu Cys Pro Ala Gly Gly Gly Ala Ala Val Gln Trp Ser 
    530                 535                 540                 


Arg Val Glu Glu Gly Val Asn Ala Tyr Trp Phe Arg Gly Leu Arg Pro 
545                 550                 555                 560 


Gly Thr Asn Tyr Ser Val Cys Leu Ala Leu Ala Gly Glu Ala Cys His 
                565                 570                 575     


Val Gln Val Val Phe Ser Thr Lys Lys Glu Leu Pro Ser Leu Leu Val 
            580                 585                 590         


Ile Val Ala Val Ser Val Phe Leu Leu Val Leu Ala Thr Val Pro Leu 
        595                 600                 605             


Leu Gly Ala Ala Cys Cys His Leu Leu Ala Lys His Pro Gly Lys Pro 
    610                 615                 620                 


Tyr Arg Leu Ile Leu Arg Pro Gln Ala Pro Asp Pro Met Glu Lys Arg 
625                 630                 635                 640 


Ile Ala Ala Asp Phe Asp Pro Arg Ala Ser Tyr Leu Glu Ser Glu Lys 
                645                 650                 655     


Ser Tyr Pro Ala Gly Gly Glu Ala Gly Gly Glu Glu Pro Glu Asp Val 
            660                 665                 670         


Gln Gly Glu Gly Leu Asp Glu Asp Ala Glu Gln Gly Asp Pro Ser Gly 
        675                 680                 685             


Asp Leu Gln Arg Glu Glu Ser Leu Ala Ala Cys Ser Leu Val Glu Ser 
    690                 695                 700                 


Gln Ser Lys Ala Asn Gln Glu Glu Phe Glu Ala Gly Ser Glu Tyr Ser 
705                 710                 715                 720 


Asp Arg Leu Pro Leu Gly Ala Glu Ala Val Asn Ile Ala Gln Glu Ile 
                725                 730                 735     


Asn Gly Asn Tyr Arg Gln Thr Ala Gly 
            740                 745 


<210>  7237
<211>  745
<212>  PRT
<213>  Homo Sapiens

<400>  7237

Met Phe Pro Leu Arg Ala Leu Trp Leu Val Trp Ala Leu Leu Gly Val 
1               5                   10                  15      


Ala Gly Ser Cys Pro Glu Pro Cys Ala Cys Val Asp Lys Tyr Ala His 
            20                  25                  30          


Gln Phe Ala Asp Cys Ala Tyr Lys Glu Leu Arg Glu Val Pro Glu Gly 
        35                  40                  45              


Leu Pro Ala Asn Val Thr Thr Leu Ser Leu Ser Ala Asn Lys Ile Thr 
    50                  55                  60                  


Val Leu Arg Arg Gly Ala Phe Ala Asp Val Thr Gln Val Thr Ser Leu 
65                  70                  75                  80  


Trp Leu Ala His Asn Glu Val Arg Thr Val Glu Pro Gly Ala Leu Ala 
                85                  90                  95      


Val Leu Ser Gln Leu Lys Asn Leu Asp Leu Ser His Asn Phe Ile Ser 
            100                 105                 110         


Ser Phe Pro Trp Ser Asp Leu Arg Asn Leu Ser Ala Leu Gln Leu Leu 
        115                 120                 125             


Lys Met Asn His Asn Arg Leu Gly Ser Leu Pro Arg Asp Ala Leu Gly 
    130                 135                 140                 


Ala Leu Pro Asp Leu Arg Ser Leu Arg Ile Asn Asn Asn Arg Leu Arg 
145                 150                 155                 160 


Thr Leu Ala Pro Gly Thr Phe Asp Ala Leu Ser Ala Leu Ser His Leu 
                165                 170                 175     


Gln Leu Tyr His Asn Pro Phe His Cys Gly Cys Gly Leu Val Trp Leu 
            180                 185                 190         


Gln Ala Trp Ala Ala Ser Thr Arg Val Ser Leu Pro Glu Pro Asp Ser 
        195                 200                 205             


Ile Ala Cys Ala Ser Pro Pro Ala Leu Gln Gly Val Pro Val Tyr Arg 
    210                 215                 220                 


Leu Pro Ala Leu Pro Cys Ala Pro Pro Ser Val His Leu Ser Ala Glu 
225                 230                 235                 240 


Pro Pro Leu Glu Ala Pro Gly Thr Pro Leu Arg Ala Gly Leu Ala Phe 
                245                 250                 255     


Val Leu His Cys Ile Ala Asp Gly His Pro Thr Pro Arg Leu Gln Trp 
            260                 265                 270         


Gln Leu Gln Ile Pro Gly Gly Thr Val Val Leu Glu Pro Pro Val Leu 
        275                 280                 285             


Ser Gly Glu Asp Asp Gly Val Gly Ala Glu Glu Gly Glu Gly Glu Gly 
    290                 295                 300                 


Asp Gly Asp Leu Leu Thr Gln Thr Gln Ala Gln Thr Pro Thr Pro Ala 
305                 310                 315                 320 


Pro Ala Trp Pro Ala Pro Pro Ala Thr Pro Arg Phe Leu Ala Leu Ala 
                325                 330                 335     


Asn Gly Ser Leu Leu Val Pro Leu Leu Ser Ala Lys Glu Ala Gly Val 
            340                 345                 350         


Tyr Thr Cys Arg Ala His Asn Glu Leu Gly Ala Asn Ser Thr Ser Ile 
        355                 360                 365             


Arg Val Ala Val Ala Ala Thr Gly Pro Pro Lys His Ala Pro Gly Ala 
    370                 375                 380                 


Gly Gly Glu Pro Asp Gly Gln Ala Pro Thr Ser Glu Arg Lys Ser Thr 
385                 390                 395                 400 


Ala Lys Gly Arg Gly Asn Ser Val Leu Pro Ser Lys Pro Glu Gly Lys 
                405                 410                 415     


Ile Lys Gly Gln Gly Leu Ala Lys Val Ser Ile Leu Gly Glu Thr Glu 
            420                 425                 430         


Thr Glu Pro Glu Glu Asp Thr Ser Glu Gly Glu Glu Ala Glu Asp Gln 
        435                 440                 445             


Ile Leu Ala Asp Pro Ala Glu Glu Gln Arg Cys Gly Asn Gly Asp Pro 
    450                 455                 460                 


Ser Arg Tyr Val Ser Asn His Ala Phe Asn Gln Ser Ala Glu Leu Lys 
465                 470                 475                 480 


Pro His Val Phe Glu Leu Gly Val Ile Ala Leu Asp Val Ala Glu Arg 
                485                 490                 495     


Glu Ala Arg Val Gln Leu Thr Pro Leu Ala Ala Arg Trp Gly Pro Gly 
            500                 505                 510         


Pro Gly Gly Ala Gly Gly Ala Pro Arg Pro Gly Arg Arg Pro Leu Arg 
        515                 520                 525             


Leu Leu Tyr Leu Cys Pro Ala Gly Gly Gly Ala Ala Val Gln Trp Ser 
    530                 535                 540                 


Arg Val Glu Glu Gly Val Asn Ala Tyr Trp Phe Arg Gly Leu Arg Pro 
545                 550                 555                 560 


Gly Thr Asn Tyr Ser Val Cys Leu Ala Leu Ala Gly Glu Ala Cys His 
                565                 570                 575     


Val Gln Val Val Phe Ser Thr Lys Lys Glu Leu Pro Ser Leu Leu Val 
            580                 585                 590         


Ile Val Ala Val Ser Val Phe Leu Leu Val Leu Ala Thr Val Pro Leu 
        595                 600                 605             


Leu Gly Ala Ala Cys Cys His Leu Leu Ala Lys His Pro Gly Lys Pro 
    610                 615                 620                 


Tyr Arg Leu Ile Leu Arg Pro Gln Ala Pro Asp Pro Met Glu Lys Arg 
625                 630                 635                 640 


Ile Ala Ala Asp Phe Asp Pro Arg Ala Ser Tyr Leu Glu Ser Glu Lys 
                645                 650                 655     


Ser Tyr Pro Ala Gly Gly Glu Ala Gly Gly Glu Glu Pro Glu Asp Val 
            660                 665                 670         


Gln Gly Glu Gly Leu Asp Glu Asp Ala Glu Gln Gly Asp Pro Ser Gly 
        675                 680                 685             


Asp Leu Gln Arg Glu Glu Ser Leu Ala Ala Cys Ser Leu Val Glu Ser 
    690                 695                 700                 


Gln Ser Lys Ala Asn Gln Glu Glu Phe Glu Ala Gly Ser Glu Tyr Ser 
705                 710                 715                 720 


Asp Arg Leu Pro Leu Gly Ala Glu Ala Val Asn Ile Ala Gln Glu Ile 
                725                 730                 735     


Asn Gly Asn Tyr Arg Gln Thr Ala Gly 
            740                 745 


<210>  7238
<211>  745
<212>  PRT
<213>  Homo Sapiens

<400>  7238

Met Phe Pro Leu Arg Ala Leu Trp Leu Val Trp Ala Leu Leu Gly Val 
1               5                   10                  15      


Ala Gly Ser Cys Pro Glu Pro Cys Ala Cys Val Asp Lys Tyr Ala His 
            20                  25                  30          


Gln Phe Ala Asp Cys Ala Tyr Lys Glu Leu Arg Glu Val Pro Glu Gly 
        35                  40                  45              


Leu Pro Ala Asn Val Thr Thr Leu Ser Leu Ser Ala Asn Lys Ile Thr 
    50                  55                  60                  


Val Leu Arg Arg Gly Ala Phe Ala Asp Val Thr Gln Val Thr Ser Leu 
65                  70                  75                  80  


Trp Leu Ala His Asn Glu Val Arg Thr Val Glu Pro Gly Ala Leu Ala 
                85                  90                  95      


Val Leu Ser Gln Leu Lys Asn Leu Asp Leu Ser His Asn Phe Ile Ser 
            100                 105                 110         


Ser Phe Pro Trp Ser Asp Leu Arg Asn Leu Ser Ala Leu Gln Leu Leu 
        115                 120                 125             


Lys Met Asn His Asn Arg Leu Gly Ser Leu Pro Arg Asp Ala Leu Gly 
    130                 135                 140                 


Ala Leu Pro Asp Leu Arg Ser Leu Arg Ile Asn Asn Asn Arg Leu Arg 
145                 150                 155                 160 


Thr Leu Ala Pro Gly Thr Phe Asp Ala Leu Ser Ala Leu Ser His Leu 
                165                 170                 175     


Gln Leu Tyr His Asn Pro Phe His Cys Gly Cys Gly Leu Val Trp Leu 
            180                 185                 190         


Gln Ala Trp Ala Ala Ser Thr Arg Val Ser Leu Pro Glu Pro Asp Ser 
        195                 200                 205             


Ile Ala Cys Ala Ser Pro Pro Ala Leu Gln Gly Val Pro Val Tyr Arg 
    210                 215                 220                 


Leu Pro Ala Leu Pro Cys Ala Pro Pro Ser Val His Leu Ser Ala Glu 
225                 230                 235                 240 


Pro Pro Leu Glu Ala Pro Gly Thr Pro Leu Arg Ala Gly Leu Ala Phe 
                245                 250                 255     


Val Leu His Cys Ile Ala Asp Gly His Pro Thr Pro Arg Leu Gln Trp 
            260                 265                 270         


Gln Leu Gln Ile Pro Gly Gly Thr Val Val Leu Glu Pro Pro Val Leu 
        275                 280                 285             


Ser Gly Glu Asp Asp Gly Val Gly Ala Glu Glu Gly Glu Gly Glu Gly 
    290                 295                 300                 


Asp Gly Asp Leu Leu Thr Gln Thr Gln Ala Gln Thr Pro Thr Pro Ala 
305                 310                 315                 320 


Pro Ala Trp Pro Ala Pro Pro Ala Thr Pro Arg Phe Leu Ala Leu Ala 
                325                 330                 335     


Asn Gly Ser Leu Leu Val Pro Leu Leu Ser Ala Lys Glu Ala Gly Val 
            340                 345                 350         


Tyr Thr Cys Arg Ala His Asn Glu Leu Gly Ala Asn Ser Thr Ser Ile 
        355                 360                 365             


Arg Val Ala Val Ala Ala Thr Gly Pro Pro Lys His Ala Pro Gly Ala 
    370                 375                 380                 


Gly Gly Glu Pro Asp Gly Gln Ala Pro Thr Ser Glu Arg Lys Ser Thr 
385                 390                 395                 400 


Ala Lys Gly Arg Gly Asn Ser Val Leu Pro Ser Lys Pro Glu Gly Lys 
                405                 410                 415     


Ile Lys Gly Gln Gly Leu Ala Lys Val Ser Ile Leu Gly Glu Thr Glu 
            420                 425                 430         


Thr Glu Pro Glu Glu Asp Thr Ser Glu Gly Glu Glu Ala Glu Asp Gln 
        435                 440                 445             


Ile Leu Ala Asp Pro Ala Glu Glu Gln Arg Cys Gly Asn Gly Asp Pro 
    450                 455                 460                 


Ser Arg Tyr Val Ser Asn His Ala Phe Asn Gln Ser Ala Glu Leu Lys 
465                 470                 475                 480 


Pro His Val Phe Glu Leu Gly Val Ile Ala Leu Asp Val Ala Glu Arg 
                485                 490                 495     


Glu Ala Arg Val Gln Leu Thr Pro Leu Ala Ala Arg Trp Gly Pro Gly 
            500                 505                 510         


Pro Gly Gly Ala Gly Gly Ala Pro Arg Pro Gly Arg Arg Pro Leu Arg 
        515                 520                 525             


Leu Leu Tyr Leu Cys Pro Ala Gly Gly Gly Ala Ala Val Gln Trp Ser 
    530                 535                 540                 


Arg Val Glu Glu Gly Val Asn Ala Tyr Trp Phe Arg Gly Leu Arg Pro 
545                 550                 555                 560 


Gly Thr Asn Tyr Ser Val Cys Leu Ala Leu Ala Gly Glu Ala Cys His 
                565                 570                 575     


Val Gln Val Val Phe Ser Thr Lys Lys Glu Leu Pro Ser Leu Leu Val 
            580                 585                 590         


Ile Val Ala Val Ser Val Phe Leu Leu Val Leu Ala Thr Val Pro Leu 
        595                 600                 605             


Leu Gly Ala Ala Cys Cys His Leu Leu Ala Lys His Pro Gly Lys Pro 
    610                 615                 620                 


Tyr Arg Leu Ile Leu Arg Pro Gln Ala Pro Asp Pro Met Glu Lys Arg 
625                 630                 635                 640 


Ile Ala Ala Asp Phe Asp Pro Arg Ala Ser Tyr Leu Glu Ser Glu Lys 
                645                 650                 655     


Ser Tyr Pro Ala Gly Gly Glu Ala Gly Gly Glu Glu Pro Glu Asp Val 
            660                 665                 670         


Gln Gly Glu Gly Leu Asp Glu Asp Ala Glu Gln Gly Asp Pro Ser Gly 
        675                 680                 685             


Asp Leu Gln Arg Glu Glu Ser Leu Ala Ala Cys Ser Leu Val Glu Ser 
    690                 695                 700                 


Gln Ser Lys Ala Asn Gln Glu Glu Phe Glu Ala Gly Ser Glu Tyr Ser 
705                 710                 715                 720 


Asp Arg Leu Pro Leu Gly Ala Glu Ala Val Asn Ile Ala Gln Glu Ile 
                725                 730                 735     


Asn Gly Asn Tyr Arg Gln Thr Ala Gly 
            740                 745 


<210>  7239
<211>  745
<212>  PRT
<213>  Homo Sapiens

<400>  7239

Met Phe Pro Leu Arg Ala Leu Trp Leu Val Trp Ala Leu Leu Gly Val 
1               5                   10                  15      


Ala Gly Ser Cys Pro Glu Pro Cys Ala Cys Val Asp Lys Tyr Ala His 
            20                  25                  30          


Gln Phe Ala Asp Cys Ala Tyr Lys Glu Leu Arg Glu Val Pro Glu Gly 
        35                  40                  45              


Leu Pro Ala Asn Val Thr Thr Leu Ser Leu Ser Ala Asn Lys Ile Thr 
    50                  55                  60                  


Val Leu Arg Arg Gly Ala Phe Ala Asp Val Thr Gln Val Thr Ser Leu 
65                  70                  75                  80  


Trp Leu Ala His Asn Glu Val Arg Thr Val Glu Pro Gly Ala Leu Ala 
                85                  90                  95      


Val Leu Ser Gln Leu Lys Asn Leu Asp Leu Ser His Asn Phe Ile Ser 
            100                 105                 110         


Ser Phe Pro Trp Ser Asp Leu Arg Asn Leu Ser Ala Leu Gln Leu Leu 
        115                 120                 125             


Lys Met Asn His Asn Arg Leu Gly Ser Leu Pro Arg Asp Ala Leu Gly 
    130                 135                 140                 


Ala Leu Pro Asp Leu Arg Ser Leu Arg Ile Asn Asn Asn Arg Leu Arg 
145                 150                 155                 160 


Thr Leu Ala Pro Gly Thr Phe Asp Ala Leu Ser Ala Leu Ser His Leu 
                165                 170                 175     


Gln Leu Tyr His Asn Pro Phe His Cys Gly Cys Gly Leu Val Trp Leu 
            180                 185                 190         


Gln Ala Trp Ala Ala Ser Thr Arg Val Ser Leu Pro Glu Pro Asp Ser 
        195                 200                 205             


Ile Ala Cys Ala Ser Pro Pro Ala Leu Gln Gly Val Pro Val Tyr Arg 
    210                 215                 220                 


Leu Pro Ala Leu Pro Cys Ala Pro Pro Ser Val His Leu Ser Ala Glu 
225                 230                 235                 240 


Pro Pro Leu Glu Ala Pro Gly Thr Pro Leu Arg Ala Gly Leu Ala Phe 
                245                 250                 255     


Val Leu His Cys Ile Ala Asp Gly His Pro Thr Pro Arg Leu Gln Trp 
            260                 265                 270         


Gln Leu Gln Ile Pro Gly Gly Thr Val Val Leu Glu Pro Pro Val Leu 
        275                 280                 285             


Ser Gly Glu Asp Asp Gly Val Gly Ala Glu Glu Gly Glu Gly Glu Gly 
    290                 295                 300                 


Asp Gly Asp Leu Leu Thr Gln Thr Gln Ala Gln Thr Pro Thr Pro Ala 
305                 310                 315                 320 


Pro Ala Trp Pro Ala Pro Pro Ala Thr Pro Arg Phe Leu Ala Leu Ala 
                325                 330                 335     


Asn Gly Ser Leu Leu Val Pro Leu Leu Ser Ala Lys Glu Ala Gly Val 
            340                 345                 350         


Tyr Thr Cys Arg Ala His Asn Glu Leu Gly Ala Asn Ser Thr Ser Ile 
        355                 360                 365             


Arg Val Ala Val Ala Ala Thr Gly Pro Pro Lys His Ala Pro Gly Ala 
    370                 375                 380                 


Gly Gly Glu Pro Asp Gly Gln Ala Pro Thr Ser Glu Arg Lys Ser Thr 
385                 390                 395                 400 


Ala Lys Gly Arg Gly Asn Ser Val Leu Pro Ser Lys Pro Glu Gly Lys 
                405                 410                 415     


Ile Lys Gly Gln Gly Leu Ala Lys Val Ser Ile Leu Gly Glu Thr Glu 
            420                 425                 430         


Thr Glu Pro Glu Glu Asp Thr Ser Glu Gly Glu Glu Ala Glu Asp Gln 
        435                 440                 445             


Ile Leu Ala Asp Pro Ala Glu Glu Gln Arg Cys Gly Asn Gly Asp Pro 
    450                 455                 460                 


Ser Arg Tyr Val Ser Asn His Ala Phe Asn Gln Ser Ala Glu Leu Lys 
465                 470                 475                 480 


Pro His Val Phe Glu Leu Gly Val Ile Ala Leu Asp Val Ala Glu Arg 
                485                 490                 495     


Glu Ala Arg Val Gln Leu Thr Pro Leu Ala Ala Arg Trp Gly Pro Gly 
            500                 505                 510         


Pro Gly Gly Ala Gly Gly Ala Pro Arg Pro Gly Arg Arg Pro Leu Arg 
        515                 520                 525             


Leu Leu Tyr Leu Cys Pro Ala Gly Gly Gly Ala Ala Val Gln Trp Ser 
    530                 535                 540                 


Arg Val Glu Glu Gly Val Asn Ala Tyr Trp Phe Arg Gly Leu Arg Pro 
545                 550                 555                 560 


Gly Thr Asn Tyr Ser Val Cys Leu Ala Leu Ala Gly Glu Ala Cys His 
                565                 570                 575     


Val Gln Val Val Phe Ser Thr Lys Lys Glu Leu Pro Ser Leu Leu Val 
            580                 585                 590         


Ile Val Ala Val Ser Val Phe Leu Leu Val Leu Ala Thr Val Pro Leu 
        595                 600                 605             


Leu Gly Ala Ala Cys Cys His Leu Leu Ala Lys His Pro Gly Lys Pro 
    610                 615                 620                 


Tyr Arg Leu Ile Leu Arg Pro Gln Ala Pro Asp Pro Met Glu Lys Arg 
625                 630                 635                 640 


Ile Ala Ala Asp Phe Asp Pro Arg Ala Ser Tyr Leu Glu Ser Glu Lys 
                645                 650                 655     


Ser Tyr Pro Ala Gly Gly Glu Ala Gly Gly Glu Glu Pro Glu Asp Val 
            660                 665                 670         


Gln Gly Glu Gly Leu Asp Glu Asp Ala Glu Gln Gly Asp Pro Ser Gly 
        675                 680                 685             


Asp Leu Gln Arg Glu Glu Ser Leu Ala Ala Cys Ser Leu Val Glu Ser 
    690                 695                 700                 


Gln Ser Lys Ala Asn Gln Glu Glu Phe Glu Ala Gly Ser Glu Tyr Ser 
705                 710                 715                 720 


Asp Arg Leu Pro Leu Gly Ala Glu Ala Val Asn Ile Ala Gln Glu Ile 
                725                 730                 735     


Asn Gly Asn Tyr Arg Gln Thr Ala Gly 
            740                 745 


<210>  7240
<211>  464
<212>  PRT
<213>  Homo Sapiens

<400>  7240

Met Val Arg Leu Ala Ala Glu Leu Leu Leu Leu Leu Gly Leu Leu Leu 
1               5                   10                  15      


Leu Thr Leu His Ile Thr Val Leu Arg Gly Ser Gly Ala Ala Asp Gly 
            20                  25                  30          


Pro Asp Ala Ala Ala Gly Asn Ala Ser Gln Ala Gln Leu Gln Asn Asn 
        35                  40                  45              


Leu Asn Val Gly Ser Asp Thr Thr Ser Glu Thr Ser Phe Ser Leu Ser 
    50                  55                  60                  


Lys Glu Ala Pro Arg Glu His Leu Asp His Gln Ala Ala His Gln Pro 
65                  70                  75                  80  


Phe Pro Arg Pro Arg Phe Arg Gln Glu Thr Gly His Pro Ser Leu Gln 
                85                  90                  95      


Arg Asp Phe Pro Arg Ser Phe Leu Leu Asp Leu Pro Asn Phe Pro Asp 
            100                 105                 110         


Leu Ser Lys Ala Asp Ile Asn Gly Gln Asn Pro Asn Ile Gln Val Thr 
        115                 120                 125             


Ile Glu Val Val Asp Gly Pro Asp Ser Glu Ala Asp Lys Asp Gln His 
    130                 135                 140                 


Pro Glu Asn Lys Pro Ser Trp Ser Val Pro Ser Pro Asp Trp Arg Ala 
145                 150                 155                 160 


Trp Trp Gln Arg Ser Leu Ser Leu Ala Arg Ala Asn Ser Gly Asp Gln 
                165                 170                 175     


Asp Tyr Lys Tyr Asp Ser Thr Ser Asp Asp Ser Asn Phe Leu Asn Pro 
            180                 185                 190         


Pro Arg Gly Trp Asp His Thr Ala Pro Gly His Arg Thr Phe Glu Thr 
        195                 200                 205             


Lys Asp Gln Pro Glu Tyr Asp Ser Thr Asp Gly Glu Gly Asp Trp Ser 
    210                 215                 220                 


Leu Trp Ser Val Cys Ser Val Thr Cys Gly Asn Gly Asn Gln Lys Arg 
225                 230                 235                 240 


Thr Arg Ser Cys Gly Tyr Ala Cys Thr Ala Thr Glu Ser Arg Thr Cys 
                245                 250                 255     


Asp Arg Pro Asn Cys Pro Gly Ile Glu Asp Thr Phe Arg Thr Ala Ala 
            260                 265                 270         


Thr Glu Val Ser Leu Leu Ala Gly Ser Glu Glu Phe Asn Ala Thr Lys 
        275                 280                 285             


Leu Phe Glu Val Asp Thr Asp Ser Cys Glu Arg Trp Met Ser Cys Lys 
    290                 295                 300                 


Ser Glu Phe Leu Lys Lys Tyr Met His Lys Val Met Asn Asp Leu Pro 
305                 310                 315                 320 


Ser Cys Pro Cys Ser Tyr Pro Thr Glu Val Ala Tyr Ser Thr Ala Asp 
                325                 330                 335     


Ile Phe Asp Arg Ile Lys Arg Lys Asp Phe Arg Trp Lys Asp Ala Ser 
            340                 345                 350         


Gly Pro Lys Glu Lys Leu Glu Ile Tyr Lys Pro Thr Ala Arg Tyr Cys 
        355                 360                 365             


Ile Arg Ser Met Leu Ser Leu Glu Ser Thr Thr Leu Ala Ala Gln His 
    370                 375                 380                 


Cys Cys Tyr Gly Asp Asn Met Gln Leu Ile Thr Arg Gly Lys Gly Ala 
385                 390                 395                 400 


Gly Thr Pro Asn Leu Ile Ser Thr Glu Phe Ser Ala Glu Leu His Tyr 
                405                 410                 415     


Lys Val Asp Val Leu Pro Trp Ile Ile Cys Lys Gly Asp Trp Ser Arg 
            420                 425                 430         


Tyr Asn Glu Ala Arg Pro Pro Asn Asn Gly Gln Lys Cys Thr Glu Ser 
        435                 440                 445             


Pro Ser Asp Glu Asp Tyr Ile Lys Gln Phe Gln Glu Ala Arg Glu Tyr 
    450                 455                 460                 


<210>  7241
<211>  76
<212>  PRT
<213>  Homo Sapiens

<400>  7241

Met Arg Ala Leu Arg Asp Arg Ala Gly Leu Leu Leu Cys Val Leu Leu 
1               5                   10                  15      


Leu Ala Ala Leu Leu Glu Ala Ala Leu Gly Leu Pro Val Lys Lys Pro 
            20                  25                  30          


Arg Leu Arg Gly Pro Arg Pro Gly Ser Leu Thr Arg Leu Ala Glu Pro 
        35                  40                  45              


Pro Phe Gln Val Arg Ala Ser Ser Glu Arg Ser Pro Ala Gly Ala Arg 
    50                  55                  60                  


Asn Leu Ala Leu Cys Gly Val Ala Gly Gln Gly Arg 
65                  70                  75      


<210>  7242
<211>  292
<212>  PRT
<213>  Homo Sapiens

<400>  7242

Met Arg Ala Leu Arg Asp Arg Ala Gly Leu Leu Leu Cys Val Leu Leu 
1               5                   10                  15      


Leu Ala Ala Leu Leu Glu Ala Ala Leu Gly Leu Pro Val Lys Lys Pro 
            20                  25                  30          


Arg Leu Arg Gly Pro Arg Pro Gly Ser Leu Thr Arg Leu Ala Glu Val 
        35                  40                  45              


Ser Ala Ser Pro Asp Pro Arg Pro Leu Lys Glu Glu Glu Glu Ala Pro 
    50                  55                  60                  


Leu Leu Pro Arg Thr His Leu Gln Ala Glu Pro His Gln His Gly Cys 
65                  70                  75                  80  


Trp Thr Val Thr Glu Pro Ala Ala Met Thr Pro Gly Asn Ala Thr Pro 
                85                  90                  95      


Pro Arg Thr Pro Glu Val Thr Pro Leu Arg Leu Glu Leu Gln Lys Leu 
            100                 105                 110         


Pro Gly Leu Ala Asn Thr Thr Leu Ser Thr Pro Asn Pro Asp Thr Gln 
        115                 120                 125             


Ala Ser Ala Ser Pro Asp Pro Arg Pro Leu Arg Glu Glu Glu Glu Ala 
    130                 135                 140                 


Arg Leu Leu Pro Arg Thr His Leu Gln Ala Glu Leu His Gln His Gly 
145                 150                 155                 160 


Cys Trp Thr Val Thr Glu Pro Ala Ala Leu Thr Pro Gly Asn Ala Thr 
                165                 170                 175     


Pro Pro Arg Thr Gln Glu Val Thr Pro Leu Leu Leu Glu Leu Gln Lys 
            180                 185                 190         


Leu Pro Glu Leu Val His Ala Thr Leu Ser Thr Pro Asn Pro Asp Asn 
        195                 200                 205             


Gln Thr Met Ser Leu Arg Arg Ser Gly Val Pro Gly Leu Pro Ala Val 
    210                 215                 220                 


Gly Thr Ala Ala Leu Ala Ser Ser Arg Gly Leu Gly Pro Val Ala Met 
225                 230                 235                 240 


Ala Ala Leu Pro Pro Arg Pro Val Pro Val Thr Cys Pro Pro Val Leu 
                245                 250                 255     


Ala Leu Arg Thr Arg Thr Pro Trp Ala Ser Pro Val Arg Ser Gly Ser 
            260                 265                 270         


Ser Trp Pro Ala Met Leu Arg Thr Cys Met Ile Lys Met Trp Thr Ala 
        275                 280                 285             


Val Arg Ser Gly 
    290         


<210>  7243
<211>  571
<212>  PRT
<213>  Homo Sapiens

<400>  7243

Met Arg Ala Leu Arg Asp Arg Ala Gly Leu Leu Leu Cys Val Leu Leu 
1               5                   10                  15      


Leu Ala Ala Leu Leu Glu Ala Ala Leu Gly Leu Pro Val Lys Lys Pro 
            20                  25                  30          


Arg Leu Arg Gly Pro Arg Pro Gly Ser Leu Thr Arg Leu Ala Glu Val 
        35                  40                  45              


Ser Ala Ser Pro Asp Pro Arg Pro Leu Lys Glu Glu Glu Glu Ala Pro 
    50                  55                  60                  


Leu Leu Pro Arg Thr His Leu Gln Ala Glu Pro His Gln His Gly Cys 
65                  70                  75                  80  


Trp Thr Val Thr Glu Pro Ala Ala Met Thr Pro Gly Asn Ala Thr Pro 
                85                  90                  95      


Pro Arg Thr Pro Glu Val Thr Pro Leu Arg Leu Glu Leu Gln Lys Leu 
            100                 105                 110         


Pro Gly Leu Ala Asn Thr Thr Leu Ser Thr Pro Asn Pro Asp Thr Gln 
        115                 120                 125             


Ala Ser Ala Ser Pro Asp Pro Arg Pro Leu Arg Glu Glu Glu Glu Ala 
    130                 135                 140                 


Arg Leu Leu Pro Arg Thr His Leu Gln Ala Glu Leu His Gln His Gly 
145                 150                 155                 160 


Cys Trp Thr Val Thr Glu Pro Ala Ala Leu Thr Pro Gly Asn Ala Thr 
                165                 170                 175     


Pro Pro Arg Thr Gln Glu Val Thr Pro Leu Leu Leu Glu Leu Gln Lys 
            180                 185                 190         


Leu Pro Glu Leu Val His Ala Thr Leu Ser Thr Pro Asn Pro Asp Asn 
        195                 200                 205             


Gln Val Thr Ile Lys Val Val Glu Asp Pro Gln Ala Glu Val Ser Ile 
    210                 215                 220                 


Asp Leu Leu Ala Glu Pro Ser Asn Pro Pro Pro Gln Asp Thr Leu Ser 
225                 230                 235                 240 


Trp Leu Pro Ala Leu Trp Ser Phe Leu Trp Gly Asp Tyr Lys Gly Glu 
                245                 250                 255     


Glu Lys Asp Arg Ala Pro Gly Glu Lys Gly Glu Glu Lys Glu Glu Asp 
            260                 265                 270         


Glu Asp Tyr Pro Ser Glu Asp Ile Glu Gly Glu Asp Gln Glu Asp Lys 
        275                 280                 285             


Glu Glu Asp Glu Glu Glu Gln Ala Leu Trp Phe Asn Gly Thr Thr Asp 
    290                 295                 300                 


Asn Trp Asp Gln Gly Trp Leu Ala Pro Gly Asp Trp Val Phe Lys Asp 
305                 310                 315                 320 


Ser Val Ser Tyr Asp Tyr Glu Pro Gln Lys Glu Trp Ser Pro Trp Ser 
                325                 330                 335     


Pro Cys Ser Gly Asn Cys Ser Thr Gly Lys Gln Gln Arg Thr Arg Pro 
            340                 345                 350         


Cys Gly Tyr Gly Cys Thr Ala Thr Glu Thr Arg Thr Cys Asp Leu Pro 
        355                 360                 365             


Ser Cys Pro Gly Thr Glu Asp Lys Asp Thr Leu Gly Leu Pro Ser Glu 
    370                 375                 380                 


Glu Trp Lys Leu Leu Ala Arg Asn Ala Thr Asp Met His Asp Gln Asp 
385                 390                 395                 400 


Val Asp Ser Cys Glu Lys Trp Leu Asn Cys Lys Ser Asp Phe Leu Ile 
                405                 410                 415     


Lys Tyr Leu Ser Gln Met Leu Arg Asp Leu Pro Ser Cys Pro Cys Ala 
            420                 425                 430         


Tyr Pro Leu Glu Ala Met Asp Ser Pro Val Ser Leu Gln Asp Glu His 
        435                 440                 445             


Gln Gly Arg Ser Phe Arg Trp Arg Asp Ala Ser Gly Pro Arg Glu Arg 
    450                 455                 460                 


Leu Asp Ile Tyr Gln Pro Thr Ala Arg Phe Cys Leu Arg Ser Met Leu 
465                 470                 475                 480 


Ser Gly Glu Ser Ser Thr Leu Ala Ala Gln His Cys Cys Tyr Asp Glu 
                485                 490                 495     


Asp Ser Arg Leu Leu Thr Arg Gly Lys Gly Ala Gly Met Pro Asn Leu 
            500                 505                 510         


Ile Ser Thr Asp Phe Ser Pro Lys Leu His Phe Lys Phe Asp Thr Thr 
        515                 520                 525             


Pro Trp Ile Leu Cys Lys Gly Asp Trp Ser Arg Leu His Ala Val Leu 
    530                 535                 540                 


Pro Pro Asn Asn Gly Arg Ala Cys Thr Asp Asn Pro Leu Glu Glu Glu 
545                 550                 555                 560 


Tyr Leu Ala Gln Leu Gln Glu Ala Lys Glu Tyr 
                565                 570     


<210>  7244
<211>  185
<212>  PRT
<213>  Homo Sapiens

<400>  7244

Met Arg Ala Leu Arg Asp Arg Ala Gly Leu Leu Leu Cys Val Leu Leu 
1               5                   10                  15      


Leu Ala Ala Leu Leu Glu Ala Ala Leu Gly Leu Pro Val Lys Lys Pro 
            20                  25                  30          


Arg Leu Arg Gly Pro Arg Pro Gly Ser Leu Thr Arg Leu Ala Glu Val 
        35                  40                  45              


Ser Ala Ser Pro Asp Pro Arg Pro Leu Lys Glu Glu Glu Glu Ala Pro 
    50                  55                  60                  


Leu Leu Pro Arg Thr His Leu Gln Ala Glu Pro His Gln His Gly Cys 
65                  70                  75                  80  


Trp Thr Val Thr Glu Pro Ala Ala Met Thr Pro Gly Asn Ala Thr Pro 
                85                  90                  95      


Pro Arg Thr Pro Glu Val Thr Pro Leu Arg Leu Glu Leu Gln Lys Leu 
            100                 105                 110         


Pro Gly Leu Ala Asn Thr Thr Leu Ser Thr Pro Asn Pro Asp Thr Gln 
        115                 120                 125             


Val Thr Ile Lys Val Val Glu Asp Pro Gln Ala Glu Val Ser Ile Asp 
    130                 135                 140                 


Leu Leu Ala Glu Pro Ser Asn Pro Pro Pro Gln Asp Thr Leu Ser Trp 
145                 150                 155                 160 


Leu Pro Ala Leu Trp Ser Phe Leu Trp Gly Asp Tyr Lys Gly Glu Glu 
                165                 170                 175     


Lys Asp Arg Ala Pro Gly Glu Lys Gly 
            180                 185 


<210>  7245
<211>  104
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7245

Xaa Cys Val Leu Leu Leu Ala Ala Leu Leu Glu Ala Ala Leu Gly Leu 
1               5                   10                  15      


Pro Val Lys Lys Pro Arg Leu Arg Gly Pro Arg Pro Gly Ser Leu Thr 
            20                  25                  30          


Arg Leu Ala Glu Val Ser Gly Gly Gly Thr Gly Leu Arg Ser Ala Leu 
        35                  40                  45              


Ser Val Pro Pro Pro Gln Pro Ala Gly Ser Ser Arg Ala Gly Ser Gly 
    50                  55                  60                  


Thr Gly Thr His Thr Gly Ser Asp Pro Pro Met Glu Arg Gly Ala Gly 
65                  70                  75                  80  


Ala Gly Arg Lys Leu Pro Asp Thr Gly Arg Cys Pro Gly Ala Pro Asp 
                85                  90                  95      


Phe Gly Ala Ser Thr Pro Arg Ala 
            100                 


<210>  7246
<211>  73
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7246

Xaa Arg Leu Ala Glu Val Ser Gly Gly Gly Thr Gly Leu Arg Ser Ala 
1               5                   10                  15      


Leu Ser Val Pro Pro Pro Gln Pro Ala Gly Ser Ser Arg Ala Gly Ser 
            20                  25                  30          


Gly Thr Gly Thr His Thr Gly Ser Asp Pro Pro Met Glu Arg Gly Ala 
        35                  40                  45              


Gly Ala Gly Arg Lys Leu Pro Asp Thr Gly Arg Cys Pro Gly Ala Pro 
    50                  55                  60                  


Asp Phe Gly Ala Ser Thr Pro Arg Ala 
65                  70              


<210>  7247
<211>  614
<212>  PRT
<213>  Homo Sapiens

<400>  7247

Met Ala Trp Glu Ala Arg Arg Glu Pro Gly Pro Arg Arg Ala Ala Val 
1               5                   10                  15      


Arg Glu Thr Val Met Leu Leu Leu Cys Leu Gly Val Pro Thr Gly Arg 
            20                  25                  30          


Pro Tyr Asn Val Asp Thr Glu Ser Ala Leu Leu Tyr Gln Gly Pro His 
        35                  40                  45              


Asn Thr Leu Phe Gly Tyr Ser Val Val Leu His Ser His Gly Ala Asn 
    50                  55                  60                  


Arg Trp Leu Leu Val Gly Ala Pro Thr Ala Asn Trp Leu Ala Asn Ala 
65                  70                  75                  80  


Ser Val Ile Asn Pro Gly Ala Ile Tyr Arg Cys Arg Ile Gly Lys Asn 
                85                  90                  95      


Pro Gly Gln Thr Cys Glu Gln Leu Gln Leu Gly Ser Pro Asn Gly Glu 
            100                 105                 110         


Pro Cys Gly Lys Thr Cys Leu Glu Glu Arg Asp Asn Gln Trp Leu Gly 
        115                 120                 125             


Val Thr Leu Ser Arg Gln Pro Gly Glu Asn Gly Ser Ile Val Thr Cys 
    130                 135                 140                 


Gly His Arg Trp Lys Asn Ile Phe Tyr Ile Lys Asn Glu Asn Lys Leu 
145                 150                 155                 160 


Pro Thr Gly Gly Cys Tyr Gly Val Pro Pro Asp Leu Arg Thr Glu Leu 
                165                 170                 175     


Ser Lys Arg Ile Ala Pro Cys Tyr Gln Asp Tyr Val Lys Lys Phe Gly 
            180                 185                 190         


Glu Asn Phe Ala Ser Cys Gln Ala Gly Ile Ser Ser Phe Tyr Thr Lys 
        195                 200                 205             


Asp Leu Ile Val Met Gly Ala Pro Gly Ser Ser Tyr Trp Thr Gly Ser 
    210                 215                 220                 


Leu Phe Val Tyr Asn Ile Thr Thr Asn Lys Tyr Lys Ala Phe Leu Asp 
225                 230                 235                 240 


Lys Gln Asn Gln Val Lys Phe Gly Ser Tyr Leu Gly Tyr Ser Val Gly 
                245                 250                 255     


Ala Gly His Phe Arg Ser Gln His Thr Thr Glu Val Val Gly Gly Ala 
            260                 265                 270         


Pro Gln His Glu Gln Ile Gly Lys Ala Tyr Ile Phe Ser Ile Asp Glu 
        275                 280                 285             


Lys Glu Leu Asn Ile Leu His Glu Met Lys Gly Lys Lys Leu Gly Ser 
    290                 295                 300                 


Tyr Phe Gly Ala Ser Val Cys Ala Val Asp Leu Asn Ala Asp Gly Phe 
305                 310                 315                 320 


Ser Asp Leu Leu Val Gly Ala Pro Met Gln Ser Thr Ile Arg Glu Glu 
                325                 330                 335     


Gly Arg Val Phe Val Tyr Ile Asn Ser Gly Ser Gly Ala Val Met Asn 
            340                 345                 350         


Ala Met Glu Thr Asn Leu Val Gly Ser Asp Lys Tyr Ala Ala Arg Phe 
        355                 360                 365             


Gly Glu Ser Ile Val Asn Leu Gly Asp Ile Asp Asn Asp Gly Phe Glu 
    370                 375                 380                 


Asp Val Ala Ile Gly Ala Pro Gln Glu Asp Asp Leu Gln Gly Ala Ile 
385                 390                 395                 400 


Tyr Ile Tyr Asn Gly Arg Ala Asp Gly Ile Ser Ser Thr Phe Ser Gln 
                405                 410                 415     


Arg Ile Glu Gly Leu Gln Ile Ser Lys Ser Leu Ser Met Phe Gly Gln 
            420                 425                 430         


Ser Ile Ser Gly Gln Ile Asp Ala Asp Asn Asn Gly Tyr Val Asp Val 
        435                 440                 445             


Ala Val Gly Ala Phe Arg Ser Asp Ser Ala Val Leu Leu Arg Thr Arg 
    450                 455                 460                 


Pro Val Val Ile Val Asp Ala Ser Leu Ser His Pro Glu Ser Val Asn 
465                 470                 475                 480 


Arg Thr Lys Phe Asp Cys Val Glu Asn Gly Trp Pro Ser Val Cys Ile 
                485                 490                 495     


Asp Leu Thr Leu Cys Phe Ser Tyr Lys Gly Lys Glu Val Pro Gly Tyr 
            500                 505                 510         


Ile Val Leu Phe Tyr Asn Met Ser Leu Asp Val Asn Arg Lys Ala Glu 
        515                 520                 525             


Ser Pro Pro Arg Phe Tyr Phe Ser Ser Asn Gly Thr Ser Asp Val Ile 
    530                 535                 540                 


Thr Gly Ser Ile Gln Val Ser Ser Arg Glu Ala Asn Cys Arg Thr His 
545                 550                 555                 560 


Gln Ala Phe Met Arg Lys Asp Val Arg Asp Ile Leu Thr Pro Ile Gln 
                565                 570                 575     


Ile Glu Ala Ala Tyr His Leu Gly Pro His Val Ile Ser Lys Arg Ser 
            580                 585                 590         


Thr Glu Glu Phe Pro Pro Leu Gln Pro Ile Leu Gln Gln Lys Lys Glu 
        595                 600                 605             


Lys Asp Ile Met Lys Lys 
    610                 


<210>  7248
<211>  1032
<212>  PRT
<213>  Homo Sapiens

<400>  7248

Met Ala Trp Glu Ala Arg Arg Glu Pro Gly Pro Arg Arg Ala Ala Val 
1               5                   10                  15      


Arg Glu Thr Val Met Leu Leu Leu Cys Leu Gly Val Pro Thr Gly Arg 
            20                  25                  30          


Pro Tyr Asn Val Asp Thr Glu Ser Ala Leu Leu Tyr Gln Gly Pro His 
        35                  40                  45              


Asn Thr Leu Phe Gly Tyr Ser Val Val Leu His Ser His Gly Ala Asn 
    50                  55                  60                  


Arg Trp Leu Leu Val Gly Ala Pro Thr Ala Asn Trp Leu Ala Asn Ala 
65                  70                  75                  80  


Ser Val Ile Asn Pro Gly Ala Ile Tyr Arg Cys Arg Ile Gly Lys Asn 
                85                  90                  95      


Pro Gly Gln Thr Cys Glu Gln Leu Gln Leu Gly Ser Pro Asn Gly Glu 
            100                 105                 110         


Pro Cys Gly Lys Thr Cys Leu Glu Glu Arg Asp Asn Gln Trp Leu Gly 
        115                 120                 125             


Val Thr Leu Ser Arg Gln Pro Gly Glu Asn Gly Ser Ile Val Thr Cys 
    130                 135                 140                 


Gly His Arg Trp Lys Asn Ile Phe Tyr Ile Lys Asn Glu Asn Lys Leu 
145                 150                 155                 160 


Pro Thr Gly Gly Cys Tyr Gly Val Pro Pro Asp Leu Arg Thr Glu Leu 
                165                 170                 175     


Ser Lys Arg Ile Ala Pro Cys Tyr Gln Asp Tyr Val Lys Lys Phe Gly 
            180                 185                 190         


Glu Asn Phe Ala Ser Cys Gln Ala Gly Ile Ser Ser Phe Tyr Thr Lys 
        195                 200                 205             


Asp Leu Ile Val Met Gly Ala Pro Gly Ser Ser Tyr Trp Thr Gly Ser 
    210                 215                 220                 


Leu Phe Val Tyr Asn Ile Thr Thr Asn Lys Tyr Lys Ala Phe Leu Asp 
225                 230                 235                 240 


Lys Gln Asn Gln Val Lys Phe Gly Ser Tyr Leu Gly Tyr Ser Val Gly 
                245                 250                 255     


Ala Gly His Phe Arg Ser Gln His Thr Thr Glu Val Val Gly Gly Ala 
            260                 265                 270         


Pro Gln His Glu Gln Ile Gly Lys Ala Tyr Ile Phe Ser Ile Asp Glu 
        275                 280                 285             


Lys Glu Leu Asn Ile Leu His Glu Met Lys Gly Lys Lys Leu Gly Ser 
    290                 295                 300                 


Tyr Phe Gly Ala Ser Val Cys Ala Val Asp Leu Asn Ala Asp Gly Phe 
305                 310                 315                 320 


Ser Asp Leu Leu Val Gly Ala Pro Met Gln Ser Thr Ile Arg Glu Glu 
                325                 330                 335     


Gly Arg Val Phe Val Tyr Ile Asn Ser Gly Ser Gly Ala Val Met Asn 
            340                 345                 350         


Ala Met Glu Thr Asn Leu Val Gly Ser Asp Lys Tyr Ala Ala Arg Phe 
        355                 360                 365             


Gly Glu Ser Ile Val Asn Leu Gly Asp Ile Asp Asn Asp Gly Phe Glu 
    370                 375                 380                 


Asp Val Ala Ile Gly Ala Pro Gln Glu Asp Asp Leu Gln Gly Ala Ile 
385                 390                 395                 400 


Tyr Ile Tyr Asn Gly Arg Ala Asp Gly Ile Ser Ser Thr Phe Ser Gln 
                405                 410                 415     


Arg Ile Glu Gly Leu Gln Ile Ser Lys Ser Leu Ser Met Phe Gly Gln 
            420                 425                 430         


Ser Ile Ser Gly Gln Ile Asp Ala Asp Asn Asn Gly Tyr Val Asp Val 
        435                 440                 445             


Ala Val Gly Ala Phe Arg Ser Asp Ser Ala Val Leu Leu Arg Thr Arg 
    450                 455                 460                 


Pro Val Val Ile Val Asp Ala Ser Leu Ser His Pro Glu Ser Val Asn 
465                 470                 475                 480 


Arg Thr Lys Phe Asp Cys Val Glu Asn Gly Trp Pro Ser Val Cys Ile 
                485                 490                 495     


Asp Leu Thr Leu Cys Phe Ser Tyr Lys Gly Lys Glu Val Pro Gly Tyr 
            500                 505                 510         


Ile Val Leu Phe Tyr Asn Met Ser Leu Asp Val Asn Arg Lys Ala Glu 
        515                 520                 525             


Ser Pro Pro Arg Phe Tyr Phe Ser Ser Asn Gly Thr Ser Asp Val Ile 
    530                 535                 540                 


Thr Gly Ser Ile Gln Val Ser Ser Arg Glu Ala Asn Cys Arg Thr His 
545                 550                 555                 560 


Gln Ala Phe Met Arg Lys Asp Val Arg Asp Ile Leu Thr Pro Ile Gln 
                565                 570                 575     


Ile Glu Ala Ala Tyr His Leu Gly Pro His Val Ile Ser Lys Arg Ser 
            580                 585                 590         


Thr Glu Glu Phe Pro Pro Leu Gln Pro Ile Leu Gln Gln Lys Lys Glu 
        595                 600                 605             


Lys Asp Ile Met Lys Lys Thr Ile Asn Phe Ala Arg Phe Cys Ala His 
    610                 615                 620                 


Glu Asn Cys Ser Ala Asp Leu Gln Val Ser Ala Lys Ile Gly Phe Leu 
625                 630                 635                 640 


Lys Pro His Glu Asn Lys Thr Tyr Leu Ala Val Gly Ser Met Lys Thr 
                645                 650                 655     


Leu Met Leu Asn Val Ser Leu Phe Asn Ala Gly Asp Asp Ala Tyr Glu 
            660                 665                 670         


Thr Thr Leu His Val Lys Leu Pro Val Gly Leu Tyr Phe Ile Lys Ile 
        675                 680                 685             


Leu Glu Leu Glu Glu Lys Gln Ile Asn Cys Glu Val Thr Asp Asn Ser 
    690                 695                 700                 


Gly Val Val Gln Leu Asp Cys Ser Ile Gly Tyr Ile Tyr Val Asp His 
705                 710                 715                 720 


Leu Ser Arg Ile Asp Ile Ser Phe Leu Leu Asp Val Ser Ser Leu Ser 
                725                 730                 735     


Arg Ala Glu Glu Asp Leu Ser Ile Thr Val His Ala Thr Cys Glu Asn 
            740                 745                 750         


Glu Glu Glu Met Asp Asn Leu Lys His Ser Arg Val Thr Val Ala Ile 
        755                 760                 765             


Pro Leu Lys Tyr Glu Val Lys Leu Thr Val His Gly Phe Val Asn Pro 
    770                 775                 780                 


Thr Ser Phe Val Tyr Gly Ser Asn Asp Glu Asn Glu Pro Glu Thr Cys 
785                 790                 795                 800 


Met Val Glu Lys Met Asn Leu Thr Phe His Val Ile Asn Thr Gly Asn 
                805                 810                 815     


Ser Met Ala Pro Asn Val Ser Val Glu Ile Met Val Pro Asn Ser Phe 
            820                 825                 830         


Ser Pro Gln Thr Asp Lys Leu Phe Asn Ile Leu Asp Val Gln Thr Thr 
        835                 840                 845             


Thr Gly Glu Cys His Phe Glu Asn Tyr Gln Arg Val Cys Ala Leu Glu 
    850                 855                 860                 


Gln Gln Lys Ser Ala Met Gln Thr Leu Lys Gly Ile Val Arg Phe Leu 
865                 870                 875                 880 


Ser Lys Thr Asp Lys Arg Leu Leu Tyr Cys Ile Lys Ala Asp Pro His 
                885                 890                 895     


Cys Leu Asn Phe Leu Cys Asn Phe Gly Lys Met Glu Ser Gly Lys Glu 
            900                 905                 910         


Ala Ser Val His Ile Gln Leu Glu Gly Arg Pro Ser Ile Leu Glu Met 
        915                 920                 925             


Asp Glu Thr Ser Ala Leu Lys Phe Glu Ile Arg Ala Thr Gly Phe Pro 
    930                 935                 940                 


Glu Pro Asn Pro Arg Val Ile Glu Leu Asn Lys Asp Glu Asn Val Ala 
945                 950                 955                 960 


His Val Leu Leu Glu Gly Leu His His Gln Arg Pro Lys Arg Tyr Phe 
                965                 970                 975     


Thr Ile Val Ile Ile Ser Ser Ser Leu Leu Leu Gly Leu Ile Val Leu 
            980                 985                 990         


Leu Leu Ile Ser Tyr Val Met Trp  Lys Ala Gly Phe Phe  Lys Arg Gln 
        995                 1000                 1005             


Tyr Lys  Ser Ile Leu Gln Glu  Glu Asn Arg Arg Asp  Ser Trp Ser 
    1010                 1015                 1020             


Tyr Ile  Asn Ser Lys Ser Asn  Asp Asp 
    1025                 1030         


<210>  7249
<211>  195
<212>  PRT
<213>  Homo Sapiens

<400>  7249

Met Ala Trp Glu Ala Arg Arg Glu Pro Gly Pro Arg Arg Ala Ala Val 
1               5                   10                  15      


Arg Glu Thr Val Met Leu Leu Leu Cys Leu Gly Val Pro Thr Gly Arg 
            20                  25                  30          


Pro Tyr Asn Val Asp Thr Glu Ser Ala Leu Leu Tyr Gln Gly Pro His 
        35                  40                  45              


Asn Thr Leu Phe Gly Tyr Ser Val Val Leu His Ser His Gly Ala Asn 
    50                  55                  60                  


Arg Trp Leu Leu Val Gly Ala Pro Thr Ala Asn Trp Leu Ala Asn Ala 
65                  70                  75                  80  


Ser Val Ile Asn Pro Gly Ala Ile Tyr Arg Cys Arg Ile Gly Lys Asn 
                85                  90                  95      


Pro Gly Gln Thr Cys Glu Gln Leu Gln Leu Gly Ser Pro Asn Gly Glu 
            100                 105                 110         


Pro Cys Gly Lys Thr Cys Leu Glu Glu Arg Asp Asn Gln Trp Leu Gly 
        115                 120                 125             


Val Thr Leu Ser Arg Gln Pro Gly Glu Asn Gly Ser Ile Val Thr Cys 
    130                 135                 140                 


Gly His Arg Trp Lys Asn Ile Phe Tyr Ile Lys Asn Glu Asn Lys Leu 
145                 150                 155                 160 


Pro Thr Gly Gly Cys Tyr Gly Val Pro Pro Asp Leu Arg Thr Glu Leu 
                165                 170                 175     


Ser Lys Arg Ile Ala Pro Cys Tyr Gln Gly Ser Ile Ser Lys Tyr Arg 
            180                 185                 190         


Ala Arg Thr 
        195 


<210>  7250
<211>  1035
<212>  PRT
<213>  Homo Sapiens

<400>  7250

Met Gly Gly Pro Ala Ala Pro Arg Gly Ala Gly Arg Leu Arg Ala Leu 
1               5                   10                  15      


Leu Leu Ala Leu Val Val Ala Gly Ile Pro Ala Gly Ala Tyr Asn Leu 
            20                  25                  30          


Asp Pro Gln Arg Pro Val His Phe Gln Gly Pro Ala Asp Ser Phe Phe 
        35                  40                  45              


Gly Tyr Ala Val Leu Glu His Phe His Asp Asn Thr Arg Trp Val Leu 
    50                  55                  60                  


Val Gly Ala Pro Lys Ala Asp Ser Lys Tyr Ser Pro Ser Val Lys Ser 
65                  70                  75                  80  


Pro Gly Ala Val Phe Lys Cys Arg Val His Thr Asn Pro Asp Arg Arg 
                85                  90                  95      


Cys Thr Glu Leu Asp Met Ala Arg Gly Lys Asn Arg Gly Thr Ser Cys 
            100                 105                 110         


Gly Lys Thr Cys Arg Glu Asp Arg Asp Asp Glu Trp Met Gly Val Ser 
        115                 120                 125             


Leu Ala Arg Gln Pro Lys Ala Asp Gly Arg Val Leu Ala Cys Ala His 
    130                 135                 140                 


Arg Trp Lys Asn Ile Tyr Tyr Glu Ala Asp His Ile Leu Pro His Gly 
145                 150                 155                 160 


Phe Cys Tyr Ile Ile Pro Ser Asn Leu Gln Ala Lys Gly Arg Thr Leu 
                165                 170                 175     


Ile Pro Cys Tyr Glu Glu Tyr Lys Lys Lys Tyr Gly Glu Glu His Gly 
            180                 185                 190         


Ser Cys Gln Ala Gly Ile Ala Gly Phe Phe Thr Glu Glu Leu Val Val 
        195                 200                 205             


Met Gly Ala Pro Gly Ser Phe Tyr Trp Ala Gly Thr Ile Lys Val Leu 
    210                 215                 220                 


Asn Leu Thr Asp Asn Thr Tyr Leu Lys Leu Asn Asp Glu Val Ile Met 
225                 230                 235                 240 


Asn Arg Arg Tyr Thr Tyr Leu Gly Tyr Ala Val Thr Ala Gly His Phe 
                245                 250                 255     


Ser His Pro Ser Thr Ile Asp Val Val Gly Gly Ala Pro Gln Asp Lys 
            260                 265                 270         


Gly Ile Gly Lys Val Tyr Ile Phe Arg Ala Asp Arg Arg Ser Gly Thr 
        275                 280                 285             


Leu Ile Lys Ile Phe Gln Ala Ser Gly Lys Lys Met Gly Ser Tyr Phe 
    290                 295                 300                 


Gly Ser Ser Leu Cys Ala Val Asp Leu Asn Gly Asp Gly Leu Ser Asp 
305                 310                 315                 320 


Leu Leu Val Gly Ala Pro Met Phe Ser Glu Ile Arg Asp Glu Gly Gln 
                325                 330                 335     


Val Thr Val Tyr Ile Asn Arg Gly Asn Gly Ala Leu Glu Glu Gln Leu 
            340                 345                 350         


Ala Leu Thr Gly Asp Gly Ala Tyr Asn Ala His Phe Gly Glu Ser Ile 
        355                 360                 365             


Ala Ser Leu Asp Asp Leu Asp Asn Asp Gly Phe Pro Asp Val Ala Ile 
    370                 375                 380                 


Gly Ala Pro Lys Glu Asp Asp Phe Ala Gly Ala Val Tyr Ile Tyr His 
385                 390                 395                 400 


Gly Asp Ala Gly Gly Ile Val Pro Gln Tyr Ser Met Lys Leu Ser Gly 
                405                 410                 415     


Gln Lys Ile Asn Pro Val Leu Arg Met Phe Gly Gln Ser Ile Ser Gly 
            420                 425                 430         


Gly Ile Asp Met Asp Gly Asn Gly Tyr Pro Asp Val Thr Val Gly Ala 
        435                 440                 445             


Phe Met Ser Asp Ser Val Val Leu Leu Arg Ala Arg Pro Val Ile Thr 
    450                 455                 460                 


Val Asp Val Ser Ile Phe Leu Pro Gly Ser Ile Asn Ile Thr Ala Pro 
465                 470                 475                 480 


Gln Cys His Asp Gly Gln Gln Pro Val Asn Cys Leu Asn Val Thr Thr 
                485                 490                 495     


Cys Phe Ser Phe His Gly Lys His Val Pro Gly Glu Ile Gly Leu Asn 
            500                 505                 510         


Tyr Val Leu Met Ala Asp Val Ala Lys Lys Glu Lys Gly Gln Met Pro 
        515                 520                 525             


Arg Val Tyr Phe Val Leu Leu Gly Glu Thr Met Gly Gln Val Thr Glu 
    530                 535                 540                 


Lys Leu Gln Leu Thr Tyr Met Glu Glu Thr Cys Arg His Tyr Val Ala 
545                 550                 555                 560 


His Val Lys Arg Arg Val Gln Asp Val Ile Ser Pro Ile Val Phe Glu 
                565                 570                 575     


Ala Ala Tyr Ser Leu Ser Glu His Val Thr Gly Glu Glu Glu Arg Glu 
            580                 585                 590         


Leu Pro Pro Leu Thr Pro Val Leu Arg Trp Lys Lys Gly Gln Lys Ile 
        595                 600                 605             


Ala Gln Lys Asn Gln Thr Val Phe Glu Arg Asn Cys Arg Ser Glu Asp 
    610                 615                 620                 


Cys Ala Ala Asp Leu Gln Leu Gln Gly Lys Leu Leu Leu Ser Ser Met 
625                 630                 635                 640 


Asp Glu Lys Thr Leu Tyr Leu Ala Leu Gly Ala Val Lys Asn Ile Ser 
                645                 650                 655     


Leu Asn Ile Ser Ile Ser Asn Leu Gly Asp Asp Ala Tyr Asp Ala Asn 
            660                 665                 670         


Val Ser Phe Asn Val Ser Arg Glu Leu Phe Phe Ile Asn Met Trp Gln 
        675                 680                 685             


Lys Glu Glu Met Gly Ile Ser Cys Glu Leu Leu Glu Ser Asp Phe Leu 
    690                 695                 700                 


Lys Cys Ser Val Gly Phe Pro Phe Met Arg Ser Lys Ser Lys Tyr Glu 
705                 710                 715                 720 


Phe Ser Val Ile Phe Asp Thr Ser His Leu Ser Gly Glu Glu Glu Val 
                725                 730                 735     


Leu Ser Phe Ile Val Thr Ala Gln Ser Gly Asn Thr Glu Arg Ser Glu 
            740                 745                 750         


Ser Leu His Asp Asn Thr Leu Val Leu Met Val Pro Leu Met His Glu 
        755                 760                 765             


Val Asp Thr Ser Ile Thr Gly Ile Met Ser Pro Thr Ser Phe Val Tyr 
    770                 775                 780                 


Gly Glu Ser Val Asp Ala Ala Asn Phe Ile Gln Leu Asp Asp Leu Glu 
785                 790                 795                 800 


Cys His Phe Gln Pro Ile Asn Ile Thr Leu Gln Val Tyr Asn Thr Gly 
                805                 810                 815     


Pro Ser Thr Leu Pro Gly Ser Ser Val Ser Ile Ser Phe Pro Asn Arg 
            820                 825                 830         


Leu Ser Ser Gly Gly Ala Glu Met Phe His Val Gln Glu Met Val Val 
        835                 840                 845             


Gly Gln Glu Lys Gly Asn Cys Ser Phe Gln Lys Asn Pro Thr Pro Cys 
    850                 855                 860                 


Ile Ile Pro Gln Glu Gln Glu Asn Ile Phe His Thr Ile Phe Ala Phe 
865                 870                 875                 880 


Phe Thr Lys Ser Gly Arg Lys Val Leu Asp Cys Glu Lys Pro Gly Ile 
                885                 890                 895     


Ser Cys Leu Thr Ala His Cys Asn Phe Ser Ala Leu Ala Lys Glu Glu 
            900                 905                 910         


Ser Arg Thr Ile Asp Ile Tyr Met Leu Leu Asn Thr Glu Ile Leu Lys 
        915                 920                 925             


Lys Asp Ser Ser Ser Val Ile Gln Phe Met Ser Arg Ala Lys Val Lys 
    930                 935                 940                 


Val Asp Pro Ala Leu Arg Val Val Glu Ile Ala His Gly Asn Pro Glu 
945                 950                 955                 960 


Glu Val Thr Val Val Phe Glu Ala Leu His Asn Leu Glu Pro Arg Gly 
                965                 970                 975     


Tyr Val Val Gly Trp Ile Ile Ala Ile Ser Leu Leu Val Gly Ile Leu 
            980                 985                 990         


Ile Phe Leu Leu Leu Ala Val Leu  Leu Trp Lys Met Gly  Phe Phe Arg 
        995                 1000                 1005             


Arg Arg  Tyr Lys Glu Ile Ile  Glu Ala Glu Lys Asn  Arg Lys Glu 
    1010                 1015                 1020             


Asn Glu  Asp Ser Trp Asp Trp  Val Gln Lys Asn Gln  
    1025                 1030                 1035 


<210>  7251
<211>  632
<212>  PRT
<213>  Homo Sapiens

<400>  7251

Met Gly Gly Pro Ala Ala Pro Arg Gly Ala Gly Arg Leu Arg Ala Leu 
1               5                   10                  15      


Leu Leu Ala Leu Val Val Ala Gly Ile Pro Ala Gly Ala Tyr Asn Leu 
            20                  25                  30          


Asp Pro Gln Arg Pro Val His Phe Gln Gly Pro Ala Asp Ser Phe Phe 
        35                  40                  45              


Gly Tyr Ala Val Leu Glu His Phe His Asp Asn Thr Arg Trp Val Leu 
    50                  55                  60                  


Val Gly Ala Pro Lys Ala Asp Ser Lys Tyr Ser Pro Ser Val Lys Ser 
65                  70                  75                  80  


Pro Gly Ala Val Phe Lys Cys Arg Val His Thr Asn Pro Asp Arg Arg 
                85                  90                  95      


Cys Thr Glu Leu Asp Met Ala Arg Gly Lys Asn Arg Gly Thr Ser Cys 
            100                 105                 110         


Gly Lys Thr Cys Arg Glu Asp Arg Asp Asp Glu Trp Met Gly Val Ser 
        115                 120                 125             


Leu Ala Arg Gln Pro Lys Ala Asp Gly Arg Val Leu Ala Cys Ala His 
    130                 135                 140                 


Arg Trp Lys Asn Ile Tyr Tyr Glu Ala Asp His Ile Leu Pro His Gly 
145                 150                 155                 160 


Phe Cys Tyr Ile Ile Pro Ser Asn Leu Gln Ala Lys Gly Arg Thr Leu 
                165                 170                 175     


Ile Pro Cys Tyr Glu Glu Tyr Lys Lys Lys Tyr Gly Glu Glu His Gly 
            180                 185                 190         


Ser Cys Gln Ala Gly Ile Ala Gly Phe Phe Thr Glu Glu Leu Val Val 
        195                 200                 205             


Met Gly Ala Pro Gly Ser Phe Tyr Trp Ala Gly Thr Ile Lys Val Leu 
    210                 215                 220                 


Asn Leu Thr Asp Asn Thr Tyr Leu Lys Leu Asn Asp Glu Val Ile Met 
225                 230                 235                 240 


Asn Arg Arg Tyr Thr Tyr Leu Gly Tyr Ala Val Thr Ala Gly His Phe 
                245                 250                 255     


Ser His Pro Ser Thr Ile Asp Val Val Gly Gly Ala Pro Gln Asp Lys 
            260                 265                 270         


Gly Ile Gly Lys Val Tyr Ile Phe Arg Ala Asp Arg Arg Ser Gly Thr 
        275                 280                 285             


Leu Ile Lys Ile Phe Gln Ala Ser Gly Lys Lys Met Gly Ser Tyr Phe 
    290                 295                 300                 


Gly Ser Ser Leu Cys Ala Val Asp Leu Asn Gly Asp Gly Leu Ser Asp 
305                 310                 315                 320 


Leu Leu Val Gly Ala Pro Met Phe Ser Glu Ile Arg Asp Glu Gly Gln 
                325                 330                 335     


Val Thr Val Tyr Ile Asn Arg Gly Asn Gly Ala Leu Glu Glu Gln Leu 
            340                 345                 350         


Ala Leu Thr Gly Asp Gly Ala Tyr Asn Ala His Phe Gly Glu Ser Ile 
        355                 360                 365             


Ala Ser Leu Asp Asp Leu Asp Asn Asp Gly Phe Pro Asp Val Ala Ile 
    370                 375                 380                 


Gly Ala Pro Lys Glu Asp Asp Phe Ala Gly Ala Val Tyr Ile Tyr His 
385                 390                 395                 400 


Gly Asp Ala Gly Gly Ile Val Pro Gln Tyr Ser Met Lys Leu Ser Gly 
                405                 410                 415     


Gln Lys Ile Asn Pro Val Leu Arg Met Phe Gly Gln Ser Ile Ser Gly 
            420                 425                 430         


Gly Ile Asp Met Asp Gly Asn Gly Tyr Pro Asp Val Thr Val Gly Ala 
        435                 440                 445             


Phe Met Ser Asp Ser Val Val Leu Leu Arg Ala Arg Pro Val Ile Thr 
    450                 455                 460                 


Val Asp Val Ser Ile Phe Leu Pro Gly Ser Ile Asn Ile Thr Ala Pro 
465                 470                 475                 480 


Gln Cys His Asp Gly Gln Gln Pro Val Asn Cys Leu Asn Val Thr Thr 
                485                 490                 495     


Cys Phe Ser Phe His Gly Lys His Val Pro Gly Glu Ile Gly Leu Asn 
            500                 505                 510         


Tyr Val Leu Met Ala Asp Val Ala Lys Lys Glu Lys Gly Gln Met Pro 
        515                 520                 525             


Arg Val Tyr Phe Val Leu Leu Gly Glu Thr Met Gly Gln Val Thr Glu 
    530                 535                 540                 


Lys Leu Gln Leu Thr Tyr Met Glu Glu Thr Cys Arg His Tyr Val Ala 
545                 550                 555                 560 


His Val Lys Arg Arg Val Gln Asp Val Ile Ser Pro Ile Val Phe Glu 
                565                 570                 575     


Ala Ala Tyr Ser Leu Ser Glu His Val Thr Gly Glu Glu Glu Arg Glu 
            580                 585                 590         


Leu Pro Pro Leu Thr Pro Val Leu Arg Trp Lys Lys Gly Gln Lys Ile 
        595                 600                 605             


Ala Gln Lys Asn Gln Val Arg Thr Leu Lys Leu Ile Leu Ser Thr Gln 
    610                 615                 620                 


Gly Gly Ser Cys Thr Glu Gln Lys 
625                 630         


<210>  7252
<211>  69
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7252

Xaa Lys Lys Asp Ser Ser Ser Val Ile Gln Phe Met Ser Arg Ala Lys 
1               5                   10                  15      


Val Lys Val Asp Pro Ala Leu Arg Val Val Glu Ile Ala His Gly Asn 
            20                  25                  30          


Pro Glu Glu Val Thr Met Gly Phe Phe Arg Arg Arg Tyr Lys Glu Ile 
        35                  40                  45              


Ile Glu Ala Glu Lys Asn Arg Lys Glu Asn Glu Asp Ser Trp Asp Trp 
    50                  55                  60                  


Val Gln Lys Asn Gln 
65                  


<210>  7253
<211>  404
<212>  PRT
<213>  Homo Sapiens

<400>  7253

Met Lys Asp Ser Cys Ile Thr Val Met Ala Met Ala Leu Leu Ser Gly 
1               5                   10                  15      


Phe Phe Phe Phe Ala Pro Ala Ser Ser Tyr Asn Leu Asp Val Arg Gly 
            20                  25                  30          


Ala Arg Ser Phe Ser Pro Pro Arg Ala Gly Arg His Phe Gly Tyr Arg 
        35                  40                  45              


Val Leu Gln Ile Lys Ser Leu Ile Pro Gln Phe Gln Gly Arg Leu Val 
    50                  55                  60                  


Ala Asn Leu Thr Tyr Thr Leu Gln Leu Asp Gly His Arg Thr Arg Arg 
65                  70                  75                  80  


Arg Gly Leu Phe Pro Gly Gly Arg His Glu Leu Arg Arg Asn Ile Ala 
                85                  90                  95      


Val Thr Thr Ser Met Ser Cys Thr Asp Phe Ser Phe His Phe Pro Met 
            100                 105                 110         


Met Phe Asn Thr Leu Val Asn Ser Ser Trp Gly Asp Ser Val Glu Leu 
        115                 120                 125             


His Ala Asn Val Thr Cys Asn Asn Glu Asp Ser Asp Leu Leu Glu Asp 
    130                 135                 140                 


Asn Ser Ala Thr Thr Ile Ile Pro Ile Leu Tyr Pro Ile Asn Ile Leu 
145                 150                 155                 160 


Ile Gln Asp Gln Glu Asp Ser Thr Leu Tyr Val Ser Phe Thr Pro Lys 
                165                 170                 175     


Gly Pro Lys Ile His Gln Val Lys His Met Tyr Gln Val Arg Ile Gln 
            180                 185                 190         


Pro Ser Ile His Asp His Asn Ile Pro Thr Leu Glu Ala Val Val Gly 
        195                 200                 205             


Val Pro Gln Pro Pro Ser Glu Gly Pro Ile Thr His Gln Trp Ser Val 
    210                 215                 220                 


Gln Met Glu Pro Pro Val Pro Cys His Tyr Glu Asp Leu Glu Arg Leu 
225                 230                 235                 240 


Pro Asp Ala Ala Glu Pro Cys Leu Pro Gly Ala Leu Phe Arg Cys Pro 
                245                 250                 255     


Val Val Phe Arg Gln Glu Ile Leu Val Gln Val Ile Gly Thr Leu Glu 
            260                 265                 270         


Leu Val Gly Glu Ile Glu Ala Ser Ser Met Phe Ser Leu Cys Ser Ser 
        275                 280                 285             


Leu Ser Ile Ser Phe Asn Ser Ser Lys His Phe His Leu Tyr Gly Ser 
    290                 295                 300                 


Asn Ala Ser Leu Ala Gln Val Val Met Lys Val Asp Val Val Tyr Glu 
305                 310                 315                 320 


Lys Gln Met Leu Tyr Leu Tyr Val Leu Ser Gly Ile Gly Gly Leu Leu 
                325                 330                 335     


Leu Leu Leu Leu Ile Phe Ile Val Leu Tyr Lys Val Gly Phe Phe Lys 
            340                 345                 350         


Arg Asn Leu Lys Glu Lys Met Glu Ala Gly Arg Gly Val Pro Asn Gly 
        355                 360                 365             


Ile Pro Ala Glu Asp Ser Glu Gln Leu Ala Ser Gly Gln Glu Ala Gly 
    370                 375                 380                 


Asp Pro Gly Cys Leu Lys Pro Leu His Glu Lys Asp Ser Glu Ser Gly 
385                 390                 395                 400 


Gly Gly Lys Asp 
                


<210>  7254
<211>  109
<212>  PRT
<213>  Homo Sapiens

<400>  7254

Met Lys Asp Ser Cys Ile Thr Val Met Ala Met Ala Leu Leu Ser Gly 
1               5                   10                  15      


Phe Phe Phe Phe Ala Pro Ala Ser Ser Tyr Asn Leu Asp Val Arg Gly 
            20                  25                  30          


Ala Arg Ser Phe Ser Pro Pro Arg Ala Gly Arg His Phe Gly Tyr Arg 
        35                  40                  45              


Val Leu Gln Leu Asp Gly His Arg Thr Arg Arg Arg Gly Leu Phe Pro 
    50                  55                  60                  


Gly Gly Arg His Glu Leu Arg Arg Asn Ile Ala Val Thr Thr Ser Met 
65                  70                  75                  80  


Ser Cys Thr Asp Phe Ser Phe His Phe Pro Ile Gln Ser Pro Ala Ser 
                85                  90                  95      


Asn Cys Phe Cys Gln Pro Leu Cys Gly Ala Glu Pro Glu 
            100                 105                 


<210>  7255
<211>  55
<212>  PRT
<213>  Homo Sapiens

<400>  7255

Met Lys Asp Ser Cys Ile Thr Val Met Ala Met Ala Leu Leu Ser Gly 
1               5                   10                  15      


Phe Phe Phe Phe Ala Pro Ala Ser Ser Tyr Asn Leu Asp Val Arg Gly 
            20                  25                  30          


Ala Arg Ser Phe Ser Pro Pro Arg Ala Gly Arg His Phe Gly Tyr Arg 
        35                  40                  45              


Val Leu Gln Val Gly Asn Gly 
    50                  55  


<210>  7256
<211>  1170
<212>  PRT
<213>  Homo Sapiens

<400>  7256

Met Lys Asp Ser Cys Ile Thr Val Met Ala Met Ala Leu Leu Ser Gly 
1               5                   10                  15      


Phe Phe Phe Phe Ala Pro Ala Ser Ser Tyr Asn Leu Asp Val Arg Gly 
            20                  25                  30          


Ala Arg Ser Phe Ser Pro Pro Arg Ala Gly Arg His Phe Gly Tyr Arg 
        35                  40                  45              


Val Leu Gln Val Gly Asn Gly Val Ile Val Gly Ala Pro Gly Glu Gly 
    50                  55                  60                  


Asn Ser Thr Gly Ser Leu Tyr Gln Cys Gln Ser Gly Thr Gly His Cys 
65                  70                  75                  80  


Leu Pro Val Thr Leu Arg Gly Ser Asn Tyr Thr Ser Lys Tyr Leu Gly 
                85                  90                  95      


Met Thr Leu Ala Thr Asp Pro Thr Asp Gly Ser Ile Leu Ala Cys Asp 
            100                 105                 110         


Pro Gly Leu Ser Arg Thr Cys Asp Gln Asn Thr Tyr Leu Ser Gly Leu 
        115                 120                 125             


Cys Tyr Leu Phe Arg Gln Asn Leu Gln Gly Pro Met Leu Gln Gly Arg 
    130                 135                 140                 


Pro Gly Phe Gln Glu Cys Ile Lys Gly Asn Val Asp Leu Val Phe Leu 
145                 150                 155                 160 


Phe Asp Gly Ser Met Ser Leu Gln Pro Asp Glu Phe Gln Lys Ile Leu 
                165                 170                 175     


Asp Phe Met Lys Asp Val Met Lys Lys Leu Ser Asn Thr Ser Tyr Gln 
            180                 185                 190         


Phe Ala Ala Val Gln Phe Ser Thr Ser Tyr Lys Thr Glu Phe Asp Phe 
        195                 200                 205             


Ser Asp Tyr Val Lys Arg Lys Asp Pro Asp Ala Leu Leu Lys His Val 
    210                 215                 220                 


Lys His Met Leu Leu Leu Thr Asn Thr Phe Gly Ala Ile Asn Tyr Val 
225                 230                 235                 240 


Ala Thr Glu Val Phe Arg Glu Glu Leu Gly Ala Arg Pro Asp Ala Thr 
                245                 250                 255     


Lys Val Leu Ile Ile Ile Thr Asp Gly Glu Ala Thr Asp Ser Gly Asn 
            260                 265                 270         


Ile Asp Ala Ala Lys Asp Ile Ile Arg Tyr Ile Ile Gly Ile Gly Lys 
        275                 280                 285             


His Phe Gln Thr Lys Glu Ser Gln Glu Thr Leu His Lys Phe Ala Ser 
    290                 295                 300                 


Lys Pro Ala Ser Glu Phe Val Lys Ile Leu Asp Thr Phe Glu Lys Leu 
305                 310                 315                 320 


Lys Asp Leu Phe Thr Glu Leu Gln Lys Lys Ile Tyr Val Ile Glu Gly 
                325                 330                 335     


Thr Ser Lys Gln Asp Leu Thr Ser Phe Asn Met Glu Leu Ser Ser Ser 
            340                 345                 350         


Gly Ile Ser Ala Asp Leu Ser Arg Gly His Ala Val Val Gly Ala Val 
        355                 360                 365             


Gly Ala Lys Asp Trp Ala Gly Gly Phe Leu Asp Leu Lys Ala Asp Leu 
    370                 375                 380                 


Gln Asp Asp Thr Phe Ile Gly Asn Glu Pro Leu Thr Pro Glu Val Arg 
385                 390                 395                 400 


Ala Gly Tyr Leu Gly Tyr Thr Val Thr Trp Leu Pro Ser Arg Gln Lys 
                405                 410                 415     


Thr Ser Leu Leu Ala Ser Gly Ala Pro Arg Tyr Gln His Met Gly Arg 
            420                 425                 430         


Val Leu Leu Phe Gln Glu Pro Gln Gly Gly Gly His Trp Ser Gln Val 
        435                 440                 445             


Gln Thr Ile His Gly Thr Gln Ile Gly Ser Tyr Phe Gly Gly Glu Leu 
    450                 455                 460                 


Cys Gly Val Asp Val Asp Gln Asp Gly Glu Thr Glu Leu Leu Leu Ile 
465                 470                 475                 480 


Gly Ala Pro Leu Phe Tyr Gly Glu Gln Arg Gly Gly Arg Val Phe Ile 
                485                 490                 495     


Tyr Gln Arg Arg Gln Leu Gly Phe Glu Glu Val Ser Glu Leu Gln Gly 
            500                 505                 510         


Asp Pro Gly Tyr Pro Leu Gly Arg Phe Gly Glu Ala Ile Thr Ala Leu 
        515                 520                 525             


Thr Asp Ile Asn Gly Asp Gly Leu Val Asp Val Ala Val Gly Ala Pro 
    530                 535                 540                 


Leu Glu Glu Gln Gly Ala Val Tyr Ile Phe Asn Gly Arg His Gly Gly 
545                 550                 555                 560 


Leu Ser Pro Gln Pro Ser Gln Arg Ile Glu Gly Thr Gln Val Leu Ser 
                565                 570                 575     


Gly Ile Gln Trp Phe Gly Arg Ser Ile His Gly Val Lys Asp Leu Glu 
            580                 585                 590         


Gly Asp Gly Leu Ala Asp Val Ala Val Gly Ala Glu Ser Gln Met Ile 
        595                 600                 605             


Val Leu Ser Ser Arg Pro Val Val Asp Met Val Thr Leu Met Ser Phe 
    610                 615                 620                 


Ser Pro Ala Glu Ile Pro Val His Glu Val Glu Cys Ser Tyr Ser Thr 
625                 630                 635                 640 


Ser Asn Lys Met Lys Glu Gly Val Asn Ile Thr Ile Cys Phe Gln Ile 
                645                 650                 655     


Lys Ser Leu Ile Pro Gln Phe Gln Gly Arg Leu Val Ala Asn Leu Thr 
            660                 665                 670         


Tyr Thr Leu Gln Leu Asp Gly His Arg Thr Arg Arg Arg Gly Leu Phe 
        675                 680                 685             


Pro Gly Gly Arg His Glu Leu Arg Arg Asn Ile Ala Val Thr Thr Ser 
    690                 695                 700                 


Met Ser Cys Thr Asp Phe Ser Phe His Phe Pro Val Cys Val Gln Asp 
705                 710                 715                 720 


Leu Ile Ser Pro Ile Asn Val Ser Leu Asn Phe Ser Leu Trp Glu Glu 
                725                 730                 735     


Glu Gly Thr Pro Arg Asp Gln Arg Ala Gln Gly Lys Asp Ile Pro Pro 
            740                 745                 750         


Ile Leu Arg Pro Ser Leu His Ser Glu Thr Trp Glu Ile Pro Phe Glu 
        755                 760                 765             


Lys Asn Cys Gly Glu Asp Lys Lys Cys Glu Ala Asn Leu Arg Val Ser 
    770                 775                 780                 


Phe Ser Pro Ala Arg Ser Arg Ala Leu Arg Leu Thr Ala Phe Ala Ser 
785                 790                 795                 800 


Leu Ser Val Glu Leu Ser Leu Ser Asn Leu Glu Glu Asp Ala Tyr Trp 
                805                 810                 815     


Val Gln Leu Asp Leu His Phe Pro Pro Gly Leu Ser Phe Arg Lys Val 
            820                 825                 830         


Glu Met Leu Lys Pro His Ser Gln Ile Pro Val Ser Cys Glu Glu Leu 
        835                 840                 845             


Pro Glu Glu Ser Arg Leu Leu Ser Arg Ala Leu Ser Cys Asn Val Ser 
    850                 855                 860                 


Ser Pro Ile Phe Lys Ala Gly His Ser Val Ala Leu Gln Met Met Phe 
865                 870                 875                 880 


Asn Thr Leu Val Asn Ser Ser Trp Gly Asp Ser Val Glu Leu His Ala 
                885                 890                 895     


Asn Val Thr Cys Asn Asn Glu Asp Ser Asp Leu Leu Glu Asp Asn Ser 
            900                 905                 910         


Ala Thr Thr Ile Ile Pro Ile Leu Tyr Pro Ile Asn Ile Leu Ile Gln 
        915                 920                 925             


Asp Gln Glu Asp Ser Thr Leu Tyr Val Ser Phe Thr Pro Lys Gly Pro 
    930                 935                 940                 


Lys Ile His Gln Val Lys His Met Tyr Gln Val Arg Ile Gln Pro Ser 
945                 950                 955                 960 


Ile His Asp His Asn Ile Pro Thr Leu Glu Ala Val Val Gly Val Pro 
                965                 970                 975     


Gln Pro Pro Ser Glu Gly Pro Ile Thr His Gln Trp Ser Val Gln Met 
            980                 985                 990         


Glu Pro Pro Val Pro Cys His Tyr  Glu Asp Leu Glu Arg  Leu Pro Asp 
        995                 1000                 1005             


Ala Ala  Glu Pro Cys Leu Pro  Gly Ala Leu Phe Arg  Cys Pro Val 
    1010                 1015                 1020             


Val Phe  Arg Gln Glu Ile Leu  Val Gln Val Ile Gly  Thr Leu Glu 
    1025                 1030                 1035             


Leu Val  Gly Glu Ile Glu Ala  Ser Ser Met Phe Ser  Leu Cys Ser 
    1040                 1045                 1050             


Ser Leu  Ser Ile Ser Phe Asn  Ser Ser Lys His Phe  His Leu Tyr 
    1055                 1060                 1065             


Gly Ser  Asn Ala Ser Leu Ala  Gln Val Val Met Lys  Val Asp Val 
    1070                 1075                 1080             


Val Tyr  Glu Lys Gln Met Leu  Tyr Leu Tyr Val Leu  Ser Gly Ile 
    1085                 1090                 1095             


Gly Gly  Leu Leu Leu Leu Leu  Leu Ile Phe Ile Val  Leu Tyr Lys 
    1100                 1105                 1110             


Val Gly  Phe Phe Lys Arg Asn  Leu Lys Glu Lys Met  Glu Ala Gly 
    1115                 1120                 1125             


Arg Gly  Val Pro Asn Gly Ile  Pro Ala Glu Asp Ser  Glu Gln Leu 
    1130                 1135                 1140             


Ala Ser  Gly Gln Glu Ala Gly  Asp Pro Gly Cys Leu  Lys Pro Leu 
    1145                 1150                 1155             


His Glu  Lys Asp Ser Glu Ser  Gly Gly Gly Lys Asp  
    1160                 1165                 1170 


<210>  7257
<211>  162
<212>  PRT
<213>  Homo Sapiens

<400>  7257

Met Lys Asp Ser Cys Ile Thr Val Met Ala Met Ala Leu Leu Ser Gly 
1               5                   10                  15      


Phe Phe Phe Phe Ala Pro Ala Ser Ser Tyr Asn Leu Asp Val Arg Gly 
            20                  25                  30          


Ala Arg Ser Phe Ser Pro Pro Arg Ala Gly Arg His Phe Gly Tyr Arg 
        35                  40                  45              


Val Leu Gln Val Gly Asn Gly Val Ile Val Gly Ala Pro Gly Glu Gly 
    50                  55                  60                  


Asn Ser Thr Gly Ser Leu Tyr Gln Cys Gln Ser Gly Thr Gly His Cys 
65                  70                  75                  80  


Leu Pro Val Thr Leu Arg Gly Ser Asn Tyr Thr Ser Lys Tyr Leu Gly 
                85                  90                  95      


Met Thr Leu Ala Thr Asp Pro Thr Asp Gly Ser Ile Leu Ala Cys Asp 
            100                 105                 110         


Pro Gly Leu Ser Arg Thr Cys Asp Gln Asn Thr Tyr Leu Ser Gly Leu 
        115                 120                 125             


Cys Tyr Leu Phe Arg Gln Asn Leu Gln Gly Pro Met Leu Gln Gly Arg 
    130                 135                 140                 


Pro Gly Phe Gln Val Cys Cys Cys Ser Val Phe His Lys Leu Gln Asn 
145                 150                 155                 160 


Arg Ile 
        


<210>  7258
<211>  1086
<212>  PRT
<213>  Homo Sapiens

<400>  7258

Met Lys Asp Ser Cys Ile Thr Val Met Ala Met Ala Leu Leu Ser Gly 
1               5                   10                  15      


Phe Phe Phe Phe Ala Pro Ala Ser Ser Tyr Asn Leu Asp Val Arg Gly 
            20                  25                  30          


Ala Arg Ser Phe Ser Pro Pro Arg Ala Gly Arg His Phe Gly Tyr Arg 
        35                  40                  45              


Val Leu Gln Val Gly Asn Gly Val Ile Val Gly Ala Pro Gly Glu Gly 
    50                  55                  60                  


Asn Ser Thr Gly Ser Leu Tyr Gln Cys Gln Ser Gly Thr Gly His Cys 
65                  70                  75                  80  


Leu Pro Val Thr Leu Arg Gly Ser Asn Tyr Thr Ser Lys Tyr Leu Gly 
                85                  90                  95      


Met Thr Leu Ala Thr Asp Pro Thr Asp Gly Ser Ile Leu Phe Ala Ala 
            100                 105                 110         


Val Gln Phe Ser Thr Ser Tyr Lys Thr Glu Phe Asp Phe Ser Asp Tyr 
        115                 120                 125             


Val Lys Arg Lys Asp Pro Asp Ala Leu Leu Lys His Val Lys His Met 
    130                 135                 140                 


Leu Leu Leu Thr Asn Thr Phe Gly Ala Ile Asn Tyr Val Ala Thr Glu 
145                 150                 155                 160 


Val Phe Arg Glu Glu Leu Gly Ala Arg Pro Asp Ala Thr Lys Val Leu 
                165                 170                 175     


Ile Ile Ile Thr Asp Gly Glu Ala Thr Asp Ser Gly Asn Ile Asp Ala 
            180                 185                 190         


Ala Lys Asp Ile Ile Arg Tyr Ile Ile Gly Ile Gly Lys His Phe Gln 
        195                 200                 205             


Thr Lys Glu Ser Gln Glu Thr Leu His Lys Phe Ala Ser Lys Pro Ala 
    210                 215                 220                 


Ser Glu Phe Val Lys Ile Leu Asp Thr Phe Glu Lys Leu Lys Asp Leu 
225                 230                 235                 240 


Phe Thr Glu Leu Gln Lys Lys Ile Tyr Val Ile Glu Gly Thr Ser Lys 
                245                 250                 255     


Gln Asp Leu Thr Ser Phe Asn Met Glu Leu Ser Ser Ser Gly Ile Ser 
            260                 265                 270         


Ala Asp Leu Ser Arg Gly His Ala Val Val Gly Ala Val Gly Ala Lys 
        275                 280                 285             


Asp Trp Ala Gly Gly Phe Leu Asp Leu Lys Ala Asp Leu Gln Asp Asp 
    290                 295                 300                 


Thr Phe Ile Gly Asn Glu Pro Leu Thr Pro Glu Val Arg Ala Gly Tyr 
305                 310                 315                 320 


Leu Gly Tyr Thr Val Thr Trp Leu Pro Ser Arg Gln Lys Thr Ser Leu 
                325                 330                 335     


Leu Ala Ser Gly Ala Pro Arg Tyr Gln His Met Gly Arg Val Leu Leu 
            340                 345                 350         


Phe Gln Glu Pro Gln Gly Gly Gly His Trp Ser Gln Val Gln Thr Ile 
        355                 360                 365             


His Gly Thr Gln Ile Gly Ser Tyr Phe Gly Gly Glu Leu Cys Gly Val 
    370                 375                 380                 


Asp Val Asp Gln Asp Gly Glu Thr Glu Leu Leu Leu Ile Gly Ala Pro 
385                 390                 395                 400 


Leu Phe Tyr Gly Glu Gln Arg Gly Gly Arg Val Phe Ile Tyr Gln Arg 
                405                 410                 415     


Arg Gln Leu Gly Phe Glu Glu Val Ser Glu Leu Gln Gly Asp Pro Gly 
            420                 425                 430         


Tyr Pro Leu Gly Arg Phe Gly Glu Ala Ile Thr Ala Leu Thr Asp Ile 
        435                 440                 445             


Asn Gly Asp Gly Leu Val Asp Val Ala Val Gly Ala Pro Leu Glu Glu 
    450                 455                 460                 


Gln Gly Ala Val Tyr Ile Phe Asn Gly Arg His Gly Gly Leu Ser Pro 
465                 470                 475                 480 


Gln Pro Ser Gln Arg Ile Glu Gly Thr Gln Val Leu Ser Gly Ile Gln 
                485                 490                 495     


Trp Phe Gly Arg Ser Ile His Gly Val Lys Asp Leu Glu Gly Asp Gly 
            500                 505                 510         


Leu Ala Asp Val Ala Val Gly Ala Glu Ser Gln Met Ile Val Leu Ser 
        515                 520                 525             


Ser Arg Pro Val Val Asp Met Val Thr Leu Met Ser Phe Ser Pro Ala 
    530                 535                 540                 


Glu Ile Pro Val His Glu Val Glu Cys Ser Tyr Ser Thr Ser Asn Lys 
545                 550                 555                 560 


Met Lys Glu Gly Val Asn Ile Thr Ile Cys Phe Gln Ile Lys Ser Leu 
                565                 570                 575     


Ile Pro Gln Phe Gln Gly Arg Leu Val Ala Asn Leu Thr Tyr Thr Leu 
            580                 585                 590         


Gln Leu Asp Gly His Arg Thr Arg Arg Arg Gly Leu Phe Pro Gly Gly 
        595                 600                 605             


Arg His Glu Leu Arg Arg Asn Ile Ala Val Thr Thr Ser Met Ser Cys 
    610                 615                 620                 


Thr Asp Phe Ser Phe His Phe Pro Val Cys Val Gln Asp Leu Ile Ser 
625                 630                 635                 640 


Pro Ile Asn Val Ser Leu Asn Phe Ser Leu Trp Glu Glu Glu Gly Thr 
                645                 650                 655     


Pro Arg Asp Gln Arg Ala Gly Lys Asp Ile Pro Pro Ile Leu Arg Pro 
            660                 665                 670         


Ser Leu His Ser Glu Thr Trp Glu Ile Pro Phe Glu Lys Asn Cys Gly 
        675                 680                 685             


Glu Asp Lys Lys Cys Glu Ala Asn Leu Arg Val Ser Phe Ser Pro Ala 
    690                 695                 700                 


Arg Ser Arg Ala Leu Arg Leu Thr Ala Phe Ala Ser Leu Ser Val Glu 
705                 710                 715                 720 


Leu Ser Leu Ser Asn Leu Glu Glu Asp Ala Tyr Trp Val Gln Leu Asp 
                725                 730                 735     


Leu His Phe Pro Pro Gly Leu Ser Phe Arg Lys Val Glu Met Leu Lys 
            740                 745                 750         


Pro His Ser Gln Ile Pro Val Ser Cys Glu Glu Leu Pro Glu Glu Ser 
        755                 760                 765             


Arg Leu Leu Ser Arg Ala Leu Ser Cys Asn Val Ser Ser Pro Ile Phe 
    770                 775                 780                 


Lys Ala Gly His Ser Val Ala Leu Gln Met Met Phe Asn Thr Leu Val 
785                 790                 795                 800 


Asn Ser Ser Trp Gly Asp Ser Val Glu Leu His Ala Asn Val Thr Cys 
                805                 810                 815     


Asn Asn Glu Asp Ser Asp Leu Leu Glu Asp Asn Ser Ala Thr Thr Ile 
            820                 825                 830         


Ile Pro Ile Leu Tyr Pro Ile Asn Ile Leu Ile Gln Asp Gln Glu Asp 
        835                 840                 845             


Ser Thr Leu Tyr Val Ser Phe Thr Pro Lys Gly Pro Lys Ile His Gln 
    850                 855                 860                 


Val Lys His Met Tyr Gln Val Arg Ile Gln Pro Ser Ile His Asp His 
865                 870                 875                 880 


Asn Ile Pro Thr Leu Glu Ala Val Val Gly Val Pro Gln Pro Pro Ser 
                885                 890                 895     


Glu Gly Pro Ile Thr His Gln Trp Ser Val Gln Met Glu Pro Pro Val 
            900                 905                 910         


Pro Cys His Tyr Glu Asp Leu Glu Arg Leu Pro Asp Ala Ala Glu Pro 
        915                 920                 925             


Cys Leu Pro Gly Ala Leu Phe Arg Cys Pro Val Val Phe Arg Gln Glu 
    930                 935                 940                 


Ile Leu Val Gln Val Ile Gly Thr Leu Glu Leu Val Gly Glu Ile Glu 
945                 950                 955                 960 


Ala Ser Ser Met Phe Ser Leu Cys Ser Ser Leu Ser Ile Ser Phe Asn 
                965                 970                 975     


Ser Ser Lys His Phe His Leu Tyr Gly Ser Asn Ala Ser Leu Ala Gln 
            980                 985                 990         


Val Val Met Lys Val Asp Val Val  Tyr Glu Lys Gln Met  Leu Tyr Leu 
        995                 1000                 1005             


Tyr Val  Leu Ser Gly Ile Gly  Gly Leu Leu Leu Leu  Leu Leu Ile 
    1010                 1015                 1020             


Phe Ile  Val Leu Tyr Lys Val  Gly Phe Phe Lys Arg  Asn Leu Lys 
    1025                 1030                 1035             


Glu Lys  Met Glu Ala Gly Arg  Gly Val Pro Asn Gly  Ile Pro Ala 
    1040                 1045                 1050             


Glu Asp  Ser Glu Gln Leu Ala  Ser Gly Gln Glu Ala  Gly Asp Pro 
    1055                 1060                 1065             


Gly Cys  Leu Lys Pro Leu His  Glu Lys Asp Ser Glu  Ser Gly Gly 
    1070                 1075                 1080             


Gly Lys  Asp 
    1085     


<210>  7259
<211>  204
<212>  PRT
<213>  Homo Sapiens

<400>  7259

Met Lys Asp Ser Cys Ile Thr Val Met Ala Met Ala Leu Leu Ser Gly 
1               5                   10                  15      


Phe Phe Phe Phe Ala Pro Ala Ser Ser Tyr Asn Leu Asp Val Arg Gly 
            20                  25                  30          


Ala Arg Ser Phe Ser Pro Pro Arg Ala Gly Arg His Phe Gly Tyr Arg 
        35                  40                  45              


Val Leu Gln Val Gly Asn Gly Val Ile Val Gly Ala Pro Gly Glu Gly 
    50                  55                  60                  


Asn Ser Thr Gly Ser Leu Tyr Gln Cys Gln Ser Gly Thr Gly His Cys 
65                  70                  75                  80  


Leu Pro Val Thr Leu Arg Gly Ser Asn Tyr Thr Ser Lys Tyr Leu Gly 
                85                  90                  95      


Met Thr Leu Ala Thr Asp Pro Thr Asp Gly Ser Ile Leu Phe Ala Ala 
            100                 105                 110         


Val Gln Phe Ser Thr Ser Tyr Lys Thr Glu Phe Asp Phe Ser Asp Tyr 
        115                 120                 125             


Val Lys Arg Lys Asp Pro Asp Ala Leu Leu Lys His Val Lys His Met 
    130                 135                 140                 


Leu Leu Leu Thr Asn Thr Phe Gly Ala Ile Asn Tyr Val Ala Thr Glu 
145                 150                 155                 160 


Val Phe Arg Glu Glu Leu Gly Ala Arg Pro Asp Ala Thr Lys Val Leu 
                165                 170                 175     


Ile Ile Ile Thr Asp Gly Glu Ala Thr Asp Ser Gly Asn Ile Asp Ala 
            180                 185                 190         


Ala Lys Asp Ile Ile Arg Tyr Ile Ile Gly Val Gly 
        195                 200                 


<210>  7260
<211>  90
<212>  PRT
<213>  Homo Sapiens

<400>  7260

Met Lys Asp Ser Cys Ile Thr Val Met Ala Met Ala Leu Leu Ser Gly 
1               5                   10                  15      


Phe Phe Phe Phe Glu Arg Pro Asn Gly Lys Leu Tyr Pro Gln Ala Leu 
            20                  25                  30          


Gly Arg Ala Phe Arg Ala Leu Gly Gly Pro Gly Val Ala Pro Ser Ile 
        35                  40                  45              


Phe Pro Glu Val Asn Ala Leu Glu Gly Lys Arg Arg Val Arg Val Ala 
    50                  55                  60                  


Trp Gly Ala Thr Ser Gly Trp Ala Trp Asp Arg Pro Pro Ala Gly His 
65                  70                  75                  80  


Val Gln Gly Arg Gly Ser Leu Gly Arg Ser 
                85                  90  


<210>  7261
<211>  41
<212>  PRT
<213>  Homo Sapiens

<400>  7261

Met Thr Leu Ala Thr Asp Pro Thr Asp Gly Ser Ile Leu Ala Cys Asp 
1               5                   10                  15      


Pro Gly Leu Ser Arg Thr Cys Asp Gln Asn Thr Tyr Leu Ser Gly Leu 
            20                  25                  30          


Cys Tyr Leu Phe Arg Gln Asn Leu Gln 
        35                  40      


<210>  7262
<211>  38
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7262

Xaa Lys Glu Gly Val Asn Ile Thr Ile Cys Phe Gln Ile Lys Ser Leu 
1               5                   10                  15      


Ile Pro Gln Phe Gln Ala Gly Trp Pro Pro Asp Gln Lys Thr Gly Val 
            20                  25                  30          


Val Pro Arg Arg Glu Thr 
        35              


<210>  7263
<211>  1163
<212>  PRT
<213>  Homo Sapiens

<400>  7263

Met Thr Arg Thr Arg Ala Ala Leu Leu Leu Phe Thr Ala Leu Ala Thr 
1               5                   10                  15      


Ser Leu Gly Phe Asn Leu Asp Thr Glu Glu Leu Thr Ala Phe Arg Val 
            20                  25                  30          


Asp Ser Ala Gly Phe Gly Asp Ser Val Val Gln Tyr Ala Asn Ser Trp 
        35                  40                  45              


Val Val Val Gly Ala Pro Gln Lys Ile Thr Ala Ala Asn Gln Thr Gly 
    50                  55                  60                  


Gly Leu Tyr Gln Cys Gly Tyr Ser Thr Gly Ala Cys Glu Pro Ile Gly 
65                  70                  75                  80  


Leu Gln Val Pro Pro Glu Ala Val Asn Met Ser Leu Gly Leu Ser Leu 
                85                  90                  95      


Ala Ser Thr Thr Ser Pro Ser Gln Leu Leu Ala Cys Gly Pro Thr Val 
            100                 105                 110         


His His Glu Cys Gly Arg Asn Met Tyr Leu Thr Gly Leu Cys Phe Leu 
        115                 120                 125             


Leu Gly Pro Thr Gln Leu Thr Gln Arg Leu Pro Val Ser Arg Gln Glu 
    130                 135                 140                 


Cys Pro Arg Gln Glu Gln Asp Ile Val Phe Leu Ile Asp Gly Ser Gly 
145                 150                 155                 160 


Ser Ile Ser Ser Arg Asn Phe Ala Thr Met Met Asn Phe Val Arg Ala 
                165                 170                 175     


Val Ile Ser Gln Phe Gln Arg Pro Ser Thr Gln Phe Ser Leu Met Gln 
            180                 185                 190         


Phe Ser Asn Lys Phe Gln Thr His Phe Thr Phe Glu Glu Phe Arg Arg 
        195                 200                 205             


Ser Ser Asn Pro Leu Ser Leu Leu Ala Ser Val His Gln Leu Gln Gly 
    210                 215                 220                 


Phe Thr Tyr Thr Ala Thr Ala Ile Gln Asn Val Val His Arg Leu Phe 
225                 230                 235                 240 


His Ala Ser Tyr Gly Ala Arg Arg Asp Ala Ala Lys Ile Leu Ile Val 
                245                 250                 255     


Ile Thr Asp Gly Lys Lys Glu Gly Asp Ser Leu Asp Tyr Lys Asp Val 
            260                 265                 270         


Ile Pro Met Ala Asp Ala Ala Gly Ile Ile Arg Tyr Ala Ile Gly Val 
        275                 280                 285             


Gly Leu Ala Phe Gln Asn Arg Asn Ser Trp Lys Glu Leu Asn Asp Ile 
    290                 295                 300                 


Ala Ser Lys Pro Ser Gln Glu His Ile Phe Lys Val Glu Asp Phe Asp 
305                 310                 315                 320 


Ala Leu Lys Asp Ile Gln Asn Gln Leu Lys Glu Lys Ile Phe Ala Ile 
                325                 330                 335     


Glu Gly Thr Glu Thr Thr Ser Ser Ser Ser Phe Glu Leu Glu Met Ala 
            340                 345                 350         


Gln Glu Gly Phe Ser Ala Val Phe Thr Pro Asp Gly Pro Val Leu Gly 
        355                 360                 365             


Ala Val Gly Ser Phe Thr Trp Ser Gly Gly Ala Phe Leu Tyr Pro Pro 
    370                 375                 380                 


Asn Met Ser Pro Thr Phe Ile Asn Met Ser Gln Glu Asn Val Asp Met 
385                 390                 395                 400 


Arg Asp Ser Tyr Leu Gly Tyr Ser Thr Glu Leu Ala Leu Trp Lys Gly 
                405                 410                 415     


Val Gln Ser Leu Val Leu Gly Ala Pro Arg Tyr Gln His Thr Gly Lys 
            420                 425                 430         


Ala Val Ile Phe Thr Gln Val Ser Arg Gln Trp Arg Met Lys Ala Glu 
        435                 440                 445             


Val Thr Gly Thr Gln Ile Gly Ser Tyr Phe Gly Ala Ser Leu Cys Ser 
    450                 455                 460                 


Val Asp Val Asp Ser Asp Gly Ser Thr Asp Leu Val Leu Ile Gly Ala 
465                 470                 475                 480 


Pro His Tyr Tyr Glu Gln Thr Arg Gly Gly Gln Val Ser Val Cys Pro 
                485                 490                 495     


Leu Pro Arg Gly Trp Arg Arg Trp Trp Cys Asp Ala Val Leu Tyr Gly 
            500                 505                 510         


Glu Gln Gly His Pro Trp Gly Arg Phe Gly Ala Ala Leu Thr Val Leu 
        515                 520                 525             


Gly Asp Val Asn Gly Asp Lys Leu Thr Asp Val Val Ile Gly Ala Pro 
    530                 535                 540                 


Gly Glu Glu Glu Asn Arg Gly Ala Val Tyr Leu Phe His Gly Val Leu 
545                 550                 555                 560 


Gly Pro Ser Ile Ser Pro Ser His Ser Gln Arg Ile Ala Gly Ser Gln 
                565                 570                 575     


Leu Ser Ser Arg Leu Gln Tyr Phe Gly Gln Ala Leu Ser Gly Gly Gln 
            580                 585                 590         


Asp Leu Thr Gln Asp Gly Leu Val Asp Leu Ala Val Gly Ala Arg Gly 
        595                 600                 605             


Gln Val Leu Leu Leu Arg Thr Arg Pro Val Leu Trp Val Gly Val Ser 
    610                 615                 620                 


Met Gln Phe Ile Pro Ala Glu Ile Pro Arg Ser Ala Phe Glu Cys Arg 
625                 630                 635                 640 


Glu Gln Val Val Ser Glu Gln Thr Leu Val Gln Ser Asn Ile Cys Leu 
                645                 650                 655     


Tyr Ile Asp Lys Arg Ser Lys Asn Leu Leu Gly Ser Arg Asp Leu Gln 
            660                 665                 670         


Ser Ser Val Thr Leu Asp Leu Ala Leu Asp Pro Gly Arg Leu Ser Pro 
        675                 680                 685             


Arg Ala Thr Phe Gln Glu Thr Lys Asn Arg Ser Leu Ser Arg Val Arg 
    690                 695                 700                 


Val Leu Gly Leu Lys Ala His Cys Glu Asn Phe Asn Leu Leu Leu Pro 
705                 710                 715                 720 


Ser Cys Val Glu Asp Ser Val Thr Pro Ile Thr Leu Arg Leu Asn Phe 
                725                 730                 735     


Thr Leu Val Gly Lys Pro Leu Leu Ala Phe Arg Asn Leu Arg Pro Met 
            740                 745                 750         


Leu Ala Ala Asp Ala Gln Arg Tyr Phe Thr Ala Ser Leu Pro Phe Glu 
        755                 760                 765             


Lys Asn Cys Gly Ala Asp His Ile Cys Gln Asp Asn Leu Gly Ile Ser 
    770                 775                 780                 


Phe Ser Phe Pro Gly Leu Lys Ser Leu Leu Val Gly Ser Asn Leu Glu 
785                 790                 795                 800 


Leu Asn Ala Glu Val Met Val Trp Asn Asp Gly Glu Asp Ser Tyr Gly 
                805                 810                 815     


Thr Thr Ile Thr Phe Ser His Pro Ala Gly Leu Ser Tyr Arg Tyr Val 
            820                 825                 830         


Ala Glu Gly Gln Lys Gln Gly Gln Leu Arg Ser Leu His Leu Thr Cys 
        835                 840                 845             


Asp Ser Ala Pro Val Gly Ser Gln Gly Thr Trp Ser Thr Ser Cys Arg 
    850                 855                 860                 


Ile Asn His Leu Ile Phe Arg Gly Gly Ala Gln Ile Thr Phe Leu Ala 
865                 870                 875                 880 


Thr Phe Asp Val Ser Pro Lys Ala Val Leu Gly Asp Arg Leu Leu Leu 
                885                 890                 895     


Thr Ala Asn Val Ser Ser Glu Asn Asn Thr Pro Arg Thr Ser Lys Thr 
            900                 905                 910         


Thr Phe Gln Leu Glu Leu Pro Val Lys Tyr Ala Val Tyr Thr Val Val 
        915                 920                 925             


Ser Ser His Glu Gln Phe Thr Lys Tyr Leu Asn Phe Ser Glu Ser Glu 
    930                 935                 940                 


Glu Lys Glu Ser His Val Ala Met His Arg Tyr Gln Val Asn Asn Leu 
945                 950                 955                 960 


Gly Gln Arg Asp Leu Pro Val Ser Ile Asn Phe Trp Val Pro Val Glu 
                965                 970                 975     


Leu Asn Gln Glu Ala Val Trp Met Asp Val Glu Val Ser His Pro Gln 
            980                 985                 990         


Asn Pro Ser Leu Arg Cys Ser Ser  Glu Lys Ile Ala Pro  Pro Ala Ser 
        995                 1000                 1005             


Asp Phe  Leu Ala His Ile Gln  Lys Asn Pro Val Leu  Asp Cys Ser 
    1010                 1015                 1020             


Ile Ala  Gly Cys Leu Arg Phe  Arg Cys Asp Val Pro  Ser Phe Ser 
    1025                 1030                 1035             


Val Gln  Glu Glu Leu Asp Phe  Thr Leu Lys Gly Asn  Leu Ser Phe 
    1040                 1045                 1050             


Gly Trp  Val Arg Gln Ile Leu  Gln Lys Lys Val Ser  Val Val Ser 
    1055                 1060                 1065             


Val Ala  Glu Ile Thr Phe Asp  Thr Ser Val Tyr Ser  Gln Leu Pro 
    1070                 1075                 1080             


Gly Gln  Glu Ala Phe Met Arg  Ala Gln Thr Thr Thr  Val Leu Glu 
    1085                 1090                 1095             


Lys Tyr  Lys Val His Asn Pro  Thr Pro Leu Ile Val  Gly Ser Ser 
    1100                 1105                 1110             


Ile Gly  Gly Leu Leu Leu Leu  Ala Leu Ile Thr Ala  Val Leu Tyr 
    1115                 1120                 1125             


Lys Val  Gly Phe Phe Lys Arg  Gln Tyr Lys Glu Met  Met Glu Glu 
    1130                 1135                 1140             


Ala Asn  Gly Gln Ile Ala Pro  Glu Asn Gly Thr Gln  Thr Pro Ser 
    1145                 1150                 1155             


Pro Pro  Ser Glu Lys 
    1160             


<210>  7264
<211>  1169
<212>  PRT
<213>  Homo Sapiens

<400>  7264

Met Thr Arg Thr Arg Ala Ala Leu Leu Leu Phe Thr Ala Leu Ala Thr 
1               5                   10                  15      


Ser Leu Gly Phe Asn Leu Asp Thr Glu Glu Leu Thr Ala Phe Arg Val 
            20                  25                  30          


Asp Ser Ala Gly Phe Gly Asp Ser Val Val Gln Tyr Ala Asn Ser Trp 
        35                  40                  45              


Val Val Val Gly Ala Pro Gln Lys Ile Thr Ala Ala Asn Gln Thr Gly 
    50                  55                  60                  


Gly Leu Tyr Gln Cys Gly Tyr Ser Thr Gly Ala Cys Glu Pro Ile Gly 
65                  70                  75                  80  


Leu Gln Val Pro Pro Glu Ala Val Asn Met Ser Leu Gly Leu Ser Leu 
                85                  90                  95      


Ala Ser Thr Thr Ser Pro Ser Gln Leu Leu Ala Cys Gly Pro Thr Val 
            100                 105                 110         


His His Glu Cys Gly Arg Asn Met Tyr Leu Thr Gly Leu Cys Phe Leu 
        115                 120                 125             


Leu Gly Pro Thr Gln Leu Thr Gln Arg Leu Pro Val Ser Arg Gln Glu 
    130                 135                 140                 


Cys Pro Arg Gln Glu Gln Asp Ile Val Phe Leu Ile Asp Gly Ser Gly 
145                 150                 155                 160 


Ser Ile Ser Ser Arg Asn Phe Ala Thr Met Met Asn Phe Val Arg Ala 
                165                 170                 175     


Val Ile Ser Gln Phe Gln Arg Pro Ser Thr Gln Phe Ser Leu Met Gln 
            180                 185                 190         


Phe Ser Asn Lys Phe Gln Thr His Phe Thr Phe Glu Glu Phe Arg Arg 
        195                 200                 205             


Ser Ser Asn Pro Leu Ser Leu Leu Ala Ser Val His Gln Leu Gln Gly 
    210                 215                 220                 


Phe Thr Tyr Thr Ala Thr Ala Ile Gln Asn Val Val His Arg Leu Phe 
225                 230                 235                 240 


His Ala Ser Tyr Gly Ala Arg Arg Asp Ala Ala Lys Ile Leu Ile Val 
                245                 250                 255     


Ile Thr Asp Gly Lys Lys Glu Gly Asp Ser Leu Asp Tyr Lys Asp Val 
            260                 265                 270         


Ile Pro Met Ala Asp Ala Ala Gly Ile Ile Arg Tyr Ala Ile Gly Val 
        275                 280                 285             


Gly Leu Ala Phe Gln Asn Arg Asn Ser Trp Lys Glu Leu Asn Asp Ile 
    290                 295                 300                 


Ala Ser Lys Pro Ser Gln Glu His Ile Phe Lys Val Glu Asp Phe Asp 
305                 310                 315                 320 


Ala Leu Lys Asp Ile Gln Asn Gln Leu Lys Glu Lys Ile Phe Ala Ile 
                325                 330                 335     


Glu Gly Thr Glu Thr Thr Ser Ser Ser Ser Phe Glu Leu Glu Met Ala 
            340                 345                 350         


Gln Glu Gly Phe Ser Ala Val Phe Thr Pro Asp Gly Pro Val Leu Gly 
        355                 360                 365             


Ala Val Gly Ser Phe Thr Trp Ser Gly Gly Ala Phe Leu Tyr Pro Pro 
    370                 375                 380                 


Asn Met Ser Pro Thr Phe Ile Asn Met Ser Gln Glu Asn Val Asp Met 
385                 390                 395                 400 


Arg Asp Ser Tyr Leu Gly Tyr Ser Thr Glu Leu Ala Leu Trp Lys Gly 
                405                 410                 415     


Val Gln Ser Leu Val Leu Gly Ala Pro Arg Tyr Gln His Thr Gly Lys 
            420                 425                 430         


Ala Val Ile Phe Thr Gln Val Ser Arg Gln Trp Arg Met Lys Ala Glu 
        435                 440                 445             


Val Thr Gly Thr Gln Ile Gly Ser Tyr Phe Gly Ala Ser Leu Cys Ser 
    450                 455                 460                 


Val Asp Val Asp Ser Asp Gly Ser Thr Asp Leu Val Leu Ile Gly Ala 
465                 470                 475                 480 


Pro His Tyr Tyr Glu Gln Thr Arg Gly Gly Gln Val Ser Val Cys Pro 
                485                 490                 495     


Leu Pro Arg Gly Trp Arg Arg Trp Trp Cys Asp Ala Val Leu Tyr Gly 
            500                 505                 510         


Glu Gln Gly His Pro Trp Gly Arg Phe Gly Ala Ala Leu Thr Val Leu 
        515                 520                 525             


Gly Asp Val Asn Gly Asp Lys Leu Thr Asp Val Val Ile Gly Ala Pro 
    530                 535                 540                 


Gly Glu Glu Glu Asn Arg Gly Ala Val Tyr Leu Phe His Gly Val Leu 
545                 550                 555                 560 


Gly Pro Ser Ile Ser Pro Ser His Ser Gln Arg Ile Ala Gly Ser Gln 
                565                 570                 575     


Leu Ser Ser Arg Leu Gln Tyr Phe Gly Gln Ala Leu Ser Gly Gly Gln 
            580                 585                 590         


Asp Leu Thr Gln Asp Gly Leu Val Asp Leu Ala Val Gly Ala Arg Gly 
        595                 600                 605             


Gln Val Leu Leu Leu Arg Thr Arg Pro Val Leu Trp Val Gly Val Ser 
    610                 615                 620                 


Met Gln Phe Ile Pro Ala Glu Ile Pro Arg Ser Ala Phe Glu Cys Arg 
625                 630                 635                 640 


Glu Gln Val Val Ser Glu Gln Thr Leu Val Gln Ser Asn Ile Cys Leu 
                645                 650                 655     


Tyr Ile Asp Lys Arg Ser Lys Asn Leu Leu Gly Ser Arg Asp Leu Gln 
            660                 665                 670         


Ser Ser Val Thr Leu Asp Leu Ala Leu Asp Pro Gly Arg Leu Ser Pro 
        675                 680                 685             


Arg Ala Thr Phe Gln Glu Thr Lys Asn Arg Ser Leu Ser Arg Val Arg 
    690                 695                 700                 


Val Leu Gly Leu Lys Ala His Cys Glu Asn Phe Asn Leu Leu Leu Pro 
705                 710                 715                 720 


Ser Cys Val Glu Asp Ser Val Thr Pro Ile Thr Leu Arg Leu Asn Phe 
                725                 730                 735     


Thr Leu Val Gly Lys Pro Leu Leu Ala Phe Arg Asn Leu Arg Pro Met 
            740                 745                 750         


Leu Ala Ala Asp Ala Gln Arg Tyr Phe Thr Ala Ser Leu Pro Phe Glu 
        755                 760                 765             


Lys Asn Cys Gly Ala Asp His Ile Cys Gln Asp Asn Leu Gly Ile Ser 
    770                 775                 780                 


Phe Ser Phe Pro Gly Leu Lys Ser Leu Leu Val Gly Ser Asn Leu Glu 
785                 790                 795                 800 


Leu Asn Ala Glu Val Met Val Trp Asn Asp Gly Glu Asp Ser Tyr Gly 
                805                 810                 815     


Thr Thr Ile Thr Phe Ser His Pro Ala Gly Leu Ser Tyr Arg Tyr Val 
            820                 825                 830         


Ala Glu Gly Gln Lys Gln Gly Gln Leu Arg Ser Leu His Leu Thr Cys 
        835                 840                 845             


Asp Ser Ala Pro Val Gly Ser Gln Gly Thr Trp Ser Thr Ser Cys Arg 
    850                 855                 860                 


Ile Asn His Leu Ile Phe Arg Gly Gly Ala Gln Ile Thr Phe Leu Ala 
865                 870                 875                 880 


Thr Phe Asp Val Ser Pro Lys Ala Val Leu Gly Asp Arg Leu Leu Leu 
                885                 890                 895     


Thr Ala Asn Val Ser Ser Glu Asn Asn Thr Pro Arg Thr Ser Lys Thr 
            900                 905                 910         


Thr Phe Gln Leu Glu Leu Pro Val Lys Tyr Ala Val Tyr Thr Val Val 
        915                 920                 925             


Ser Ser His Glu Gln Phe Thr Lys Tyr Leu Asn Phe Ser Glu Ser Glu 
    930                 935                 940                 


Glu Lys Glu Ser His Val Ala Met His Arg Tyr Gln Val Asn Asn Leu 
945                 950                 955                 960 


Gly Gln Arg Asp Leu Pro Val Ser Ile Asn Phe Trp Val Pro Val Glu 
                965                 970                 975     


Leu Asn Gln Glu Ala Val Trp Met Asp Val Glu Val Ser His Pro Gln 
            980                 985                 990         


Asn Pro Ser Leu Arg Cys Ser Ser  Glu Lys Ile Ala Pro  Pro Ala Ser 
        995                 1000                 1005             


Asp Phe  Leu Ala His Ile Gln  Lys Asn Pro Val Leu  Asp Cys Ser 
    1010                 1015                 1020             


Ile Ala  Gly Cys Leu Arg Phe  Arg Cys Asp Val Pro  Ser Phe Ser 
    1025                 1030                 1035             


Val Gln  Glu Glu Leu Asp Phe  Thr Leu Lys Gly Asn  Leu Ser Phe 
    1040                 1045                 1050             


Gly Trp  Val Arg Gln Ile Leu  Gln Lys Lys Val Ser  Val Val Ser 
    1055                 1060                 1065             


Val Ala  Glu Ile Thr Phe Asp  Thr Ser Val Tyr Ser  Gln Leu Pro 
    1070                 1075                 1080             


Gly Gln  Glu Ala Phe Met Arg  Ala Gln Thr Thr Thr  Val Leu Glu 
    1085                 1090                 1095             


Lys Tyr  Lys Val His Asn Pro  Thr Pro Leu Ile Val  Gly Ser Ser 
    1100                 1105                 1110             


Ile Gly  Gly Leu Leu Leu Leu  Ala Leu Ile Thr Ala  Val Leu Tyr 
    1115                 1120                 1125             


Lys Val  Gly Phe Phe Lys Arg  Gln Tyr Lys Glu Met  Met Glu Glu 
    1130                 1135                 1140             


Ala Asn  Gly Gln Ile Ala Pro  Glu Asn Gly Thr Gln  Thr Pro Ser 
    1145                 1150                 1155             


Pro Pro  Thr Pro His Tyr Pro  Gln Asp Asn Val 
    1160                 1165                 


<210>  7265
<211>  181
<212>  PRT
<213>  Homo Sapiens

<400>  7265

Met Thr Arg Thr Arg Ala Ala Leu Leu Leu Phe Thr Ala Leu Ala Thr 
1               5                   10                  15      


Ser Leu Gly Phe Asn Leu Asp Thr Glu Glu Leu Thr Ala Phe Arg Val 
            20                  25                  30          


Asp Ser Ala Gly Phe Gly Asp Ser Val Val Gln Tyr Ala Asn Ser Trp 
        35                  40                  45              


Val Val Val Gly Ala Pro Gln Lys Ile Thr Ala Ala Asn Gln Thr Gly 
    50                  55                  60                  


Gly Leu Tyr Gln Cys Gly Tyr Ser Thr Gly Ala Cys Glu Pro Ile Gly 
65                  70                  75                  80  


Leu Gln Val Pro Pro Glu Ala Val Asn Met Ser Leu Gly Leu Ser Leu 
                85                  90                  95      


Ala Ser Thr Thr Ser Pro Ser Gln Leu Leu Leu Thr Gln Arg Leu Pro 
            100                 105                 110         


Val Ser Arg Gln Gly Glu Cys Arg Asp His Gln Gly Phe Glu Glu Leu 
        115                 120                 125             


Thr His Ile Gln Leu Gly Val Arg Trp Ala Arg Asp Ser Leu Ala Arg 
    130                 135                 140                 


Val Asp Gln Lys Glu Gly Ile Trp Lys Lys Ser Tyr His Val Leu Gln 
145                 150                 155                 160 


Trp Phe Leu Thr Leu Leu Pro Ala His Pro Ala Asp Arg Pro His Ala 
                165                 170                 175     


Ala Gly Pro Phe Leu 
            180     


<210>  7266
<211>  49
<212>  PRT
<213>  Homo Sapiens

<400>  7266

Met Asn Leu Gln Pro Ile Phe Trp Ile Gly Leu Ile Ser Ser Val Cys 
1               5                   10                  15      


Cys Val Phe Ala Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala 
            20                  25                  30          


Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys 
        35                  40                  45              


Thr 
    


<210>  7267
<211>  89
<212>  PRT
<213>  Homo Sapiens

<400>  7267

Met Asn Leu Gln Pro Ile Phe Trp Ile Gly Leu Ile Ser Ser Val Cys 
1               5                   10                  15      


Cys Val Phe Ala Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala 
            20                  25                  30          


Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys 
        35                  40                  45              


Thr Asn Ser Thr Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys 
    50                  55                  60                  


Asp Asp Leu Glu Ala Leu Lys Lys Lys Gly Cys Pro Pro Asp Asp Ile 
65                  70                  75                  80  


Glu Asn Pro Arg Gly Ser Lys Asp Ile 
                85                  


<210>  7268
<211>  104
<212>  PRT
<213>  Homo Sapiens

<400>  7268

Met Asn Leu Gln Pro Ile Phe Trp Ile Gly Leu Ile Ser Ser Val Cys 
1               5                   10                  15      


Cys Val Phe Ala Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala 
            20                  25                  30          


Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys 
        35                  40                  45              


Thr Asn Ser Thr Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys 
    50                  55                  60                  


Asp Asp Leu Glu Ala Leu Lys Lys Lys Gly Cys Pro Pro Asp Asp Ile 
65                  70                  75                  80  


Glu Asn Pro Arg Gly Ser Lys Asp Ile Lys Lys Asn Lys Asn Val Thr 
                85                  90                  95      


Asn Arg Ser Lys Gly Thr Ala Glu 
            100                 


<210>  7269
<211>  125
<212>  PRT
<213>  Homo Sapiens

<400>  7269

Met Asn Leu Gln Pro Ile Phe Trp Ile Gly Leu Ile Ser Ser Val Cys 
1               5                   10                  15      


Cys Val Phe Ala Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala 
            20                  25                  30          


Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys 
        35                  40                  45              


Thr Asn Ser Thr Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys 
    50                  55                  60                  


Asp Asp Leu Glu Ala Leu Lys Lys Lys Gly Cys Pro Pro Asp Asp Ile 
65                  70                  75                  80  


Glu Asn Pro Arg Gly Ser Lys Asp Ile Lys Lys Asn Lys Asn Val Thr 
                85                  90                  95      


Asn Arg Ser Lys Gly Thr Ala Glu Lys Leu Lys Pro Glu Asp Ile Thr 
            100                 105                 110         


Gln Ile Gln Pro Gln Gln Leu Val Leu Arg Leu Arg Ser 
        115                 120                 125 


<210>  7270
<211>  136
<212>  PRT
<213>  Homo Sapiens

<400>  7270

Met Asn Leu Gln Pro Ile Phe Trp Ile Gly Leu Ile Ser Ser Val Cys 
1               5                   10                  15      


Cys Val Phe Ala Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala 
            20                  25                  30          


Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys 
        35                  40                  45              


Thr Asn Ser Thr Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys 
    50                  55                  60                  


Asp Asp Leu Glu Ala Leu Lys Lys Lys Gly Cys Pro Pro Asp Asp Ile 
65                  70                  75                  80  


Glu Asn Pro Arg Gly Ser Lys Asp Ile Lys Lys Asn Lys Asn Val Thr 
                85                  90                  95      


Asn Arg Ser Lys Gly Thr Ala Glu Lys Leu Lys Pro Glu Asp Ile Thr 
            100                 105                 110         


Gln Ile Gln Pro Gln Gln Leu Val Leu Arg Leu Arg Ser Gly Glu Pro 
        115                 120                 125             


Gln Thr Phe Thr Leu Lys Phe Lys 
    130                 135     


<210>  7271
<211>  143
<212>  PRT
<213>  Homo Sapiens

<400>  7271

Met Asn Leu Gln Pro Ile Phe Trp Ile Gly Leu Ile Ser Ser Val Cys 
1               5                   10                  15      


Cys Val Phe Ala Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala 
            20                  25                  30          


Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys 
        35                  40                  45              


Thr Asn Ser Thr Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys 
    50                  55                  60                  


Asp Asp Leu Glu Ala Leu Lys Lys Lys Gly Cys Pro Pro Asp Asp Ile 
65                  70                  75                  80  


Glu Asn Pro Arg Gly Ser Lys Asp Ile Lys Lys Asn Lys Asn Val Thr 
                85                  90                  95      


Asn Arg Ser Lys Gly Thr Ala Glu Lys Leu Lys Pro Glu Asp Ile Thr 
            100                 105                 110         


Gln Ile Gln Pro Gln Gln Leu Val Leu Arg Leu Arg Ser Gly Glu Pro 
        115                 120                 125             


Gln Thr Phe Thr Leu Lys Phe Lys Arg Ala Glu Asp Tyr Pro Ile 
    130                 135                 140             


<210>  7272
<211>  163
<212>  PRT
<213>  Homo Sapiens

<400>  7272

Met Asn Leu Gln Pro Ile Phe Trp Ile Gly Leu Ile Ser Ser Val Cys 
1               5                   10                  15      


Cys Val Phe Ala Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala 
            20                  25                  30          


Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys 
        35                  40                  45              


Thr Asn Ser Thr Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys 
    50                  55                  60                  


Asp Asp Leu Glu Ala Leu Lys Lys Lys Gly Cys Pro Pro Asp Asp Ile 
65                  70                  75                  80  


Glu Asn Pro Arg Gly Ser Lys Asp Ile Lys Lys Asn Lys Asn Val Thr 
                85                  90                  95      


Asn Arg Ser Lys Gly Thr Ala Glu Lys Leu Lys Pro Glu Asp Ile Thr 
            100                 105                 110         


Gln Ile Gln Pro Gln Gln Leu Val Leu Arg Leu Arg Ser Gly Glu Pro 
        115                 120                 125             


Gln Thr Phe Thr Leu Lys Phe Lys Arg Ala Glu Asp Tyr Pro Ile Asp 
    130                 135                 140                 


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Glu 
145                 150                 155                 160 


Asn Val Lys 
            


<210>  7273
<211>  798
<212>  PRT
<213>  Homo Sapiens

<400>  7273

Met Asn Leu Gln Pro Ile Phe Trp Ile Gly Leu Ile Ser Ser Val Cys 
1               5                   10                  15      


Cys Val Phe Ala Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala 
            20                  25                  30          


Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys 
        35                  40                  45              


Thr Asn Ser Thr Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys 
    50                  55                  60                  


Asp Asp Leu Glu Ala Leu Lys Lys Lys Gly Cys Pro Pro Asp Asp Ile 
65                  70                  75                  80  


Glu Asn Pro Arg Gly Ser Lys Asp Ile Lys Lys Asn Lys Asn Val Thr 
                85                  90                  95      


Asn Arg Ser Lys Gly Thr Ala Glu Lys Leu Lys Pro Glu Asp Ile Thr 
            100                 105                 110         


Gln Ile Gln Pro Gln Gln Leu Val Leu Arg Leu Arg Ser Gly Glu Pro 
        115                 120                 125             


Gln Thr Phe Thr Leu Lys Phe Lys Arg Ala Glu Asp Tyr Pro Ile Asp 
    130                 135                 140                 


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Glu 
145                 150                 155                 160 


Asn Val Lys Ser Leu Gly Thr Asp Leu Met Asn Glu Met Arg Arg Ile 
                165                 170                 175     


Thr Ser Asp Phe Arg Ile Gly Phe Gly Ser Phe Val Glu Lys Thr Val 
            180                 185                 190         


Met Pro Tyr Ile Ser Thr Thr Pro Ala Lys Leu Arg Asn Pro Cys Thr 
        195                 200                 205             


Ser Glu Gln Asn Cys Thr Ser Pro Phe Ser Tyr Lys Asn Val Leu Ser 
    210                 215                 220                 


Leu Thr Asn Lys Gly Glu Val Phe Asn Glu Leu Val Gly Lys Gln Arg 
225                 230                 235                 240 


Ile Ser Gly Asn Leu Asp Ser Pro Glu Gly Gly Phe Asp Ala Ile Met 
                245                 250                 255     


Gln Val Ala Val Cys Gly Ser Leu Ile Gly Trp Arg Asn Val Thr Arg 
            260                 265                 270         


Leu Leu Val Phe Ser Thr Asp Ala Gly Phe His Phe Ala Gly Asp Gly 
        275                 280                 285             


Lys Leu Gly Gly Ile Val Leu Pro Asn Asp Gly Gln Cys His Leu Glu 
    290                 295                 300                 


Asn Asn Met Tyr Thr Met Ser His Tyr Tyr Asp Tyr Pro Ser Ile Ala 
305                 310                 315                 320 


His Leu Val Gln Lys Leu Ser Glu Asn Asn Ile Gln Thr Ile Phe Ala 
                325                 330                 335     


Val Thr Glu Glu Phe Gln Pro Val Tyr Lys Glu Leu Lys Asn Leu Ile 
            340                 345                 350         


Pro Lys Ser Ala Val Gly Thr Leu Ser Ala Asn Ser Ser Asn Val Ile 
        355                 360                 365             


Gln Leu Ile Ile Asp Ala Tyr Asn Ser Leu Ser Ser Glu Val Ile Leu 
    370                 375                 380                 


Glu Asn Gly Lys Leu Ser Glu Gly Val Thr Ile Ser Tyr Lys Ser Tyr 
385                 390                 395                 400 


Cys Lys Asn Gly Val Asn Gly Thr Gly Glu Asn Gly Arg Lys Cys Ser 
                405                 410                 415     


Asn Ile Ser Ile Gly Asp Glu Val Gln Phe Glu Ile Ser Ile Thr Ser 
            420                 425                 430         


Asn Lys Cys Pro Lys Lys Asp Ser Asp Ser Phe Lys Ile Arg Pro Leu 
        435                 440                 445             


Gly Phe Thr Glu Glu Val Glu Val Ile Leu Gln Tyr Ile Cys Glu Cys 
    450                 455                 460                 


Glu Cys Gln Ser Glu Gly Ile Pro Glu Ser Pro Lys Cys His Glu Gly 
465                 470                 475                 480 


Asn Gly Thr Phe Glu Cys Gly Ala Cys Arg Cys Asn Glu Gly Arg Val 
                485                 490                 495     


Gly Arg His Cys Glu Cys Ser Thr Asp Glu Val Asn Ser Glu Asp Met 
            500                 505                 510         


Asp Ala Tyr Cys Arg Lys Glu Asn Ser Ser Glu Ile Cys Ser Asn Asn 
        515                 520                 525             


Gly Glu Cys Val Cys Gly Gln Cys Val Cys Arg Lys Arg Asp Asn Thr 
    530                 535                 540                 


Asn Glu Ile Tyr Ser Gly Lys Phe Cys Glu Cys Asp Asn Phe Asn Cys 
545                 550                 555                 560 


Asp Arg Ser Asn Gly Leu Ile Cys Gly Gly Asn Gly Val Cys Lys Cys 
                565                 570                 575     


Arg Val Cys Glu Cys Asn Pro Asn Tyr Thr Gly Ser Ala Cys Asp Cys 
            580                 585                 590         


Ser Leu Asp Thr Ser Thr Cys Glu Ala Ser Asn Gly Gln Ile Cys Asn 
        595                 600                 605             


Gly Arg Gly Ile Cys Glu Cys Gly Val Cys Lys Cys Thr Asp Pro Lys 
    610                 615                 620                 


Phe Gln Gly Gln Thr Cys Glu Met Cys Gln Thr Cys Leu Gly Val Cys 
625                 630                 635                 640 


Ala Glu His Lys Glu Cys Val Gln Cys Arg Ala Phe Asn Lys Gly Glu 
                645                 650                 655     


Lys Lys Asp Thr Cys Thr Gln Glu Cys Ser Tyr Phe Asn Ile Thr Lys 
            660                 665                 670         


Val Glu Ser Arg Asp Lys Leu Pro Gln Pro Val Gln Pro Asp Pro Val 
        675                 680                 685             


Ser His Cys Lys Glu Lys Asp Val Asp Asp Cys Trp Phe Tyr Phe Thr 
    690                 695                 700                 


Tyr Ser Val Asn Gly Asn Asn Glu Val Met Val His Val Val Glu Asn 
705                 710                 715                 720 


Pro Glu Cys Pro Thr Gly Pro Asp Ile Ile Pro Ile Val Ala Gly Val 
                725                 730                 735     


Val Ala Gly Ile Val Leu Ile Gly Leu Ala Leu Leu Leu Ile Trp Lys 
            740                 745                 750         


Leu Leu Met Ile Ile His Asp Arg Arg Glu Phe Ala Lys Phe Glu Lys 
        755                 760                 765             


Glu Lys Met Asn Ala Lys Trp Asp Thr Gly Glu Asn Pro Ile Tyr Lys 
    770                 775                 780                 


Ser Ala Val Thr Thr Val Val Asn Pro Lys Tyr Glu Gly Lys 
785                 790                 795             


<210>  7274
<211>  798
<212>  PRT
<213>  Homo Sapiens

<400>  7274

Met Asn Leu Gln Pro Ile Phe Trp Ile Gly Leu Ile Ser Ser Val Cys 
1               5                   10                  15      


Cys Val Phe Ala Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala 
            20                  25                  30          


Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys 
        35                  40                  45              


Thr Asn Ser Thr Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys 
    50                  55                  60                  


Asp Asp Leu Glu Ala Leu Lys Lys Lys Gly Cys Pro Pro Asp Asp Ile 
65                  70                  75                  80  


Glu Asn Pro Arg Gly Ser Lys Asp Ile Lys Lys Asn Lys Asn Val Thr 
                85                  90                  95      


Asn Arg Ser Lys Gly Thr Ala Glu Lys Leu Lys Pro Glu Asp Ile Thr 
            100                 105                 110         


Gln Ile Gln Pro Gln Gln Leu Val Leu Arg Leu Arg Ser Gly Glu Pro 
        115                 120                 125             


Gln Thr Phe Thr Leu Lys Phe Lys Arg Ala Glu Asp Tyr Pro Ile Asp 
    130                 135                 140                 


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Glu 
145                 150                 155                 160 


Asn Val Lys Ser Leu Gly Thr Asp Leu Met Asn Glu Met Arg Arg Ile 
                165                 170                 175     


Thr Ser Asp Phe Arg Ile Gly Phe Gly Ser Phe Val Glu Lys Thr Val 
            180                 185                 190         


Met Pro Tyr Ile Ser Thr Thr Pro Ala Lys Leu Arg Asn Pro Cys Thr 
        195                 200                 205             


Ser Glu Gln Asn Cys Thr Ser Pro Phe Ser Tyr Lys Asn Val Leu Ser 
    210                 215                 220                 


Leu Thr Asn Lys Gly Glu Val Phe Asn Glu Leu Val Gly Lys Gln Arg 
225                 230                 235                 240 


Ile Ser Gly Asn Leu Asp Ser Pro Glu Gly Gly Phe Asp Ala Ile Met 
                245                 250                 255     


Gln Val Ala Val Cys Gly Ser Leu Ile Gly Trp Arg Asn Val Thr Arg 
            260                 265                 270         


Leu Leu Val Phe Ser Thr Asp Ala Gly Phe His Phe Ala Gly Asp Gly 
        275                 280                 285             


Lys Leu Gly Gly Ile Val Leu Pro Asn Asp Gly Gln Cys His Leu Glu 
    290                 295                 300                 


Asn Asn Met Tyr Thr Met Ser His Tyr Tyr Asp Tyr Pro Ser Ile Ala 
305                 310                 315                 320 


His Leu Val Gln Lys Leu Ser Glu Asn Asn Ile Gln Thr Ile Phe Ala 
                325                 330                 335     


Val Thr Glu Glu Phe Gln Pro Val Tyr Lys Glu Leu Lys Asn Leu Ile 
            340                 345                 350         


Pro Lys Ser Ala Val Gly Thr Leu Ser Ala Asn Ser Ser Asn Val Ile 
        355                 360                 365             


Gln Leu Ile Ile Asp Ala Tyr Asn Ser Leu Ser Ser Glu Val Ile Leu 
    370                 375                 380                 


Glu Asn Gly Lys Leu Ser Glu Gly Val Thr Ile Ser Tyr Lys Ser Tyr 
385                 390                 395                 400 


Cys Lys Asn Gly Val Asn Gly Thr Gly Glu Asn Gly Arg Lys Cys Ser 
                405                 410                 415     


Asn Ile Ser Ile Gly Asp Glu Val Gln Phe Glu Ile Ser Ile Thr Ser 
            420                 425                 430         


Asn Lys Cys Pro Lys Lys Asp Ser Asp Ser Phe Lys Ile Arg Pro Leu 
        435                 440                 445             


Gly Phe Thr Glu Glu Val Glu Val Ile Leu Gln Tyr Ile Cys Glu Cys 
    450                 455                 460                 


Glu Cys Gln Ser Glu Gly Ile Pro Glu Ser Pro Lys Cys His Glu Gly 
465                 470                 475                 480 


Asn Gly Thr Phe Glu Cys Gly Ala Cys Arg Cys Asn Glu Gly Arg Val 
                485                 490                 495     


Gly Arg His Cys Glu Cys Ser Thr Asp Glu Val Asn Ser Glu Asp Met 
            500                 505                 510         


Asp Ala Tyr Cys Arg Lys Glu Asn Ser Ser Glu Ile Cys Ser Asn Asn 
        515                 520                 525             


Gly Glu Cys Val Cys Gly Gln Cys Val Cys Arg Lys Arg Asp Asn Thr 
    530                 535                 540                 


Asn Glu Ile Tyr Ser Gly Lys Phe Cys Glu Cys Asp Asn Phe Asn Cys 
545                 550                 555                 560 


Asp Arg Ser Asn Gly Leu Ile Cys Gly Gly Asn Gly Val Cys Lys Cys 
                565                 570                 575     


Arg Val Cys Glu Cys Asn Pro Asn Tyr Thr Gly Ser Ala Cys Asp Cys 
            580                 585                 590         


Ser Leu Asp Thr Ser Thr Cys Glu Ala Ser Asn Gly Gln Ile Cys Asn 
        595                 600                 605             


Gly Arg Gly Ile Cys Glu Cys Gly Val Cys Lys Cys Thr Asp Pro Lys 
    610                 615                 620                 


Phe Gln Gly Gln Thr Cys Glu Met Cys Gln Thr Cys Leu Gly Val Cys 
625                 630                 635                 640 


Ala Glu His Lys Glu Cys Val Gln Cys Arg Ala Phe Asn Lys Gly Glu 
                645                 650                 655     


Lys Lys Asp Thr Cys Thr Gln Glu Cys Ser Tyr Phe Asn Ile Thr Lys 
            660                 665                 670         


Val Glu Ser Arg Asp Lys Leu Pro Gln Pro Val Gln Pro Asp Pro Val 
        675                 680                 685             


Ser His Cys Lys Glu Lys Asp Val Asp Asp Cys Trp Phe Tyr Phe Thr 
    690                 695                 700                 


Tyr Ser Val Asn Gly Asn Asn Glu Val Met Val His Val Val Glu Asn 
705                 710                 715                 720 


Pro Glu Cys Pro Thr Gly Pro Asp Ile Ile Pro Ile Val Ala Gly Val 
                725                 730                 735     


Val Ala Gly Ile Val Leu Ile Gly Leu Ala Leu Leu Leu Ile Trp Lys 
            740                 745                 750         


Leu Leu Met Ile Ile His Asp Arg Arg Glu Phe Ala Lys Phe Glu Lys 
        755                 760                 765             


Glu Lys Met Asn Ala Lys Trp Asp Thr Gly Glu Asn Pro Ile Tyr Lys 
    770                 775                 780                 


Ser Ala Val Thr Thr Val Val Asn Pro Lys Tyr Glu Gly Lys 
785                 790                 795             


<210>  7275
<211>  801
<212>  PRT
<213>  Homo Sapiens

<400>  7275

Met Asn Leu Gln Pro Ile Phe Trp Ile Gly Leu Ile Ser Ser Val Cys 
1               5                   10                  15      


Cys Val Phe Ala Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala 
            20                  25                  30          


Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys 
        35                  40                  45              


Thr Asn Ser Thr Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys 
    50                  55                  60                  


Asp Asp Leu Glu Ala Leu Lys Lys Lys Gly Cys Pro Pro Asp Asp Ile 
65                  70                  75                  80  


Glu Asn Pro Arg Gly Ser Lys Asp Ile Lys Lys Asn Lys Asn Val Thr 
                85                  90                  95      


Asn Arg Ser Lys Gly Thr Ala Glu Lys Leu Lys Pro Glu Asp Ile Thr 
            100                 105                 110         


Gln Ile Gln Pro Gln Gln Leu Val Leu Arg Leu Arg Ser Gly Glu Pro 
        115                 120                 125             


Gln Thr Phe Thr Leu Lys Phe Lys Arg Ala Glu Asp Tyr Pro Ile Asp 
    130                 135                 140                 


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Glu 
145                 150                 155                 160 


Asn Val Lys Ser Leu Gly Thr Asp Leu Met Asn Glu Met Arg Arg Ile 
                165                 170                 175     


Thr Ser Asp Phe Arg Ile Gly Phe Gly Ser Phe Val Glu Lys Thr Val 
            180                 185                 190         


Met Pro Tyr Ile Ser Thr Thr Pro Ala Lys Leu Arg Asn Pro Cys Thr 
        195                 200                 205             


Ser Glu Gln Asn Cys Thr Ser Pro Phe Ser Tyr Lys Asn Val Leu Ser 
    210                 215                 220                 


Leu Thr Asn Lys Gly Glu Val Phe Asn Glu Leu Val Gly Lys Gln Arg 
225                 230                 235                 240 


Ile Ser Gly Asn Leu Asp Ser Pro Glu Gly Gly Phe Asp Ala Ile Met 
                245                 250                 255     


Gln Val Ala Val Cys Gly Ser Leu Ile Gly Trp Arg Asn Val Thr Arg 
            260                 265                 270         


Leu Leu Val Phe Ser Thr Asp Ala Gly Phe His Phe Ala Gly Asp Gly 
        275                 280                 285             


Lys Leu Gly Gly Ile Val Leu Pro Asn Asp Gly Gln Cys His Leu Glu 
    290                 295                 300                 


Asn Asn Met Tyr Thr Met Ser His Tyr Tyr Asp Tyr Pro Ser Ile Ala 
305                 310                 315                 320 


His Leu Val Gln Lys Leu Ser Glu Asn Asn Ile Gln Thr Ile Phe Ala 
                325                 330                 335     


Val Thr Glu Glu Phe Gln Pro Val Tyr Lys Glu Leu Lys Asn Leu Ile 
            340                 345                 350         


Pro Lys Ser Ala Val Gly Thr Leu Ser Ala Asn Ser Ser Asn Val Ile 
        355                 360                 365             


Gln Leu Ile Ile Asp Ala Tyr Asn Ser Leu Ser Ser Glu Val Ile Leu 
    370                 375                 380                 


Glu Asn Gly Lys Leu Ser Glu Gly Val Thr Ile Ser Tyr Lys Ser Tyr 
385                 390                 395                 400 


Cys Lys Asn Gly Val Asn Gly Thr Gly Glu Asn Gly Arg Lys Cys Ser 
                405                 410                 415     


Asn Ile Ser Ile Gly Asp Glu Val Gln Phe Glu Ile Ser Ile Thr Ser 
            420                 425                 430         


Asn Lys Cys Pro Lys Lys Asp Ser Asp Ser Phe Lys Ile Arg Pro Leu 
        435                 440                 445             


Gly Phe Thr Glu Glu Val Glu Val Ile Leu Gln Tyr Ile Cys Glu Cys 
    450                 455                 460                 


Glu Cys Gln Ser Glu Gly Ile Pro Glu Ser Pro Lys Cys His Glu Gly 
465                 470                 475                 480 


Asn Gly Thr Phe Glu Cys Gly Ala Cys Arg Cys Asn Glu Gly Arg Val 
                485                 490                 495     


Gly Arg His Cys Glu Cys Ser Thr Asp Glu Val Asn Ser Glu Asp Met 
            500                 505                 510         


Asp Ala Tyr Cys Arg Lys Glu Asn Ser Ser Glu Ile Cys Ser Asn Asn 
        515                 520                 525             


Gly Glu Cys Val Cys Gly Gln Cys Val Cys Arg Lys Arg Asp Asn Thr 
    530                 535                 540                 


Asn Glu Ile Tyr Ser Gly Lys Phe Cys Glu Cys Asp Asn Phe Asn Cys 
545                 550                 555                 560 


Asp Arg Ser Asn Gly Leu Ile Cys Gly Gly Asn Gly Val Cys Lys Cys 
                565                 570                 575     


Arg Val Cys Glu Cys Asn Pro Asn Tyr Thr Gly Ser Ala Cys Asp Cys 
            580                 585                 590         


Ser Leu Asp Thr Ser Thr Cys Glu Ala Ser Asn Gly Gln Ile Cys Asn 
        595                 600                 605             


Gly Arg Gly Ile Cys Glu Cys Gly Val Cys Lys Cys Thr Asp Pro Lys 
    610                 615                 620                 


Phe Gln Gly Gln Thr Cys Glu Met Cys Gln Thr Cys Leu Gly Val Cys 
625                 630                 635                 640 


Ala Glu His Lys Glu Cys Val Gln Cys Arg Ala Phe Asn Lys Gly Glu 
                645                 650                 655     


Lys Lys Asp Thr Cys Thr Gln Glu Cys Ser Tyr Phe Asn Ile Thr Lys 
            660                 665                 670         


Val Glu Ser Arg Asp Lys Leu Pro Gln Pro Val Gln Pro Asp Pro Val 
        675                 680                 685             


Ser His Cys Lys Glu Lys Asp Val Asp Asp Cys Trp Phe Tyr Phe Thr 
    690                 695                 700                 


Tyr Ser Val Asn Gly Asn Asn Glu Val Met Val His Val Val Glu Asn 
705                 710                 715                 720 


Pro Glu Cys Pro Thr Gly Pro Asp Ile Ile Pro Ile Val Ala Gly Val 
                725                 730                 735     


Val Ala Gly Ile Val Leu Ile Gly Leu Ala Leu Leu Leu Ile Trp Lys 
            740                 745                 750         


Leu Leu Met Ile Ile His Asp Arg Arg Glu Phe Ala Lys Phe Glu Lys 
        755                 760                 765             


Glu Lys Met Asn Ala Lys Trp Asp Thr Gln Glu Asn Pro Ile Tyr Lys 
    770                 775                 780                 


Ser Pro Ile Asn Asn Phe Lys Asn Pro Asn Tyr Gly Arg Lys Ala Gly 
785                 790                 795                 800 


Leu 
    


<210>  7276
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  7276

Met Asn Leu Gln Pro Ile Phe Trp Ile Gly Leu Ile Ser Ser Val Cys 
1               5                   10                  15      


Cys Val Phe Ala Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala 
            20                  25                  30          


Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys 
        35                  40                  45              


Thr Asn Ser Val Ser Lys Thr Phe Leu Gln Glu Gly Met Pro Thr Ser 
    50                  55                  60                  


Ala Arg Cys Asp Asp Leu Glu Ala Leu Lys Lys Lys Gly Cys Pro Pro 
65                  70                  75                  80  


Asp Asp Ile Glu Asn Pro Arg Gly Ser Lys Asp Ile Lys Lys Asn Lys 
                85                  90                  95      


Asn Val Thr Asn Arg Ser Lys Gly Thr Ala Glu Lys Leu Lys Pro Glu 
            100                 105                 110         


Asp Ile Thr Gln Ile Gln Pro Gln Gln Leu Val Leu Arg Leu Arg Ser 
        115                 120                 125             


Gly Glu Pro Gln Thr Phe Thr Leu Lys Phe Lys Arg Ala Glu Asp Tyr 
    130                 135                 140                 


Pro Ile Asp Leu Tyr Tyr Leu Met 
145                 150         


<210>  7277
<211>  14
<212>  PRT
<213>  Homo Sapiens

<400>  7277

Met Pro Thr Ser Ala Arg Cys Asp Asp Leu Glu Ala Leu Lys 
1               5                   10                  


<210>  7278
<211>  31
<212>  PRT
<213>  Homo Sapiens

<400>  7278

Met Pro Thr Ser Ala Arg Cys Asp Asp Leu Glu Ala Leu Lys Lys Lys 
1               5                   10                  15      


Gly Cys Pro Pro Asp Asp Ile Glu Asn Pro Arg Gly Ser Lys Asp 
            20                  25                  30      


<210>  7279
<211>  98
<212>  PRT
<213>  Homo Sapiens

<400>  7279

Met Pro Thr Ser Ala Arg Cys Asp Asp Leu Glu Ala Leu Lys Lys Lys 
1               5                   10                  15      


Gly Cys Pro Pro Asp Asp Ile Glu Asn Pro Arg Gly Ser Lys Asp Ile 
            20                  25                  30          


Lys Lys Asn Lys Asn Val Thr Asn Arg Ser Lys Gly Thr Ala Glu Lys 
        35                  40                  45              


Leu Lys Pro Glu Asp Ile Thr Gln Ile Gln Pro Gln Gln Leu Val Leu 
    50                  55                  60                  


Arg Leu Arg Ser Gly Glu Pro Gln Thr Phe Thr Leu Lys Phe Lys Arg 
65                  70                  75                  80  


Ala Glu Asp Tyr Pro Ile Asp Leu Tyr Tyr Leu Met Asp Leu Ser Tyr 
                85                  90                  95      


Ser Met 
        


<210>  7280
<211>  108
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7280

Xaa Asp Met Asp Ala Tyr Cys Arg Lys Glu Asn Ser Ser Glu Ile Cys 
1               5                   10                  15      


Ser Asn Asn Gly Glu Cys Val Cys Gly Gln Cys Val Cys Arg Lys Arg 
            20                  25                  30          


Asp Asn Thr Asn Glu Ile Tyr Ser Gly Lys Phe Cys Glu Cys Asp Asn 
        35                  40                  45              


Phe Asn Cys Asp Arg Ser Asn Gly Leu Ile Cys Gly Gly Asn Gly Val 
    50                  55                  60                  


Cys Lys Cys Arg Val Cys Glu Cys Asn Pro Asn Tyr Thr Gly Ser Ala 
65                  70                  75                  80  


Cys Asp Cys Ser Leu Asp Thr Ser Thr Cys Glu Ala Ser Asn Gly Gln 
                85                  90                  95      


Ile Cys Asn Gly Arg Gly Ile Cys Glu Cys Gly Val 
            100                 105             


<210>  7281
<211>  70
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7281

Xaa Val Ala Gly Val Val Ala Gly Ile Val Leu Ile Gly Leu Ala Leu 
1               5                   10                  15      


Leu Leu Ile Trp Lys Leu Leu Met Ile Ile His Asp Arg Arg Glu Phe 
            20                  25                  30          


Ala Lys Phe Glu Lys Glu Lys Met Asn Ala Lys Trp Asp Thr Gln Glu 
        35                  40                  45              


Asn Pro Ile Tyr Lys Ser Pro Ile Asn Asn Phe Lys Asn Pro Asn Tyr 
    50                  55                  60                  


Gly Arg Lys Ala Gly Leu 
65                  70  


<210>  7282
<211>  322
<212>  PRT
<213>  Homo Sapiens

<400>  7282

Gly Arg Leu Gly Lys Asp Leu Ala Thr Gly Val Leu Ser Gln Glu Cys 
1               5                   10                  15      


Thr Lys Phe Lys Val Ser Ser Cys Arg Glu Cys Ile Glu Ser Gly Pro 
            20                  25                  30          


Gly Cys Thr Trp Cys Gln Lys Leu Asn Phe Thr Gly Pro Gly Asp Pro 
        35                  40                  45              


Asp Ser Ile Arg Cys Asp Thr Arg Pro Gln Leu Leu Met Arg Gly Cys 
    50                  55                  60                  


Ala Ala Asp Asp Ile Met Asp Pro Thr Ser Leu Ala Glu Thr Gln Glu 
65                  70                  75                  80  


Asp His Asn Gly Gly Gln Lys Gln Leu Ser Pro Gln Lys Val Thr Leu 
                85                  90                  95      


Tyr Leu Arg Pro Gly Gln Ala Ala Ala Phe Asn Val Thr Phe Arg Arg 
            100                 105                 110         


Ala Lys Gly Tyr Pro Ile Asp Leu Tyr Tyr Leu Met Asp Leu Ser Tyr 
        115                 120                 125             


Ser Met Leu Asp Asp Leu Arg Asn Val Lys Lys Leu Gly Gly Asp Leu 
    130                 135                 140                 


Leu Arg Ala Leu Asn Glu Ile Thr Glu Ser Gly Arg Ile Gly Phe Gly 
145                 150                 155                 160 


Ser Phe Val Asp Lys Thr Val Leu Pro Phe Val Asn Thr His Pro Asp 
                165                 170                 175     


Lys Leu Arg Asn Pro Cys Pro Asn Lys Glu Lys Glu Cys Gln Pro Pro 
            180                 185                 190         


Phe Ala Phe Arg His Val Leu Lys Leu Thr Asn Asn Ser Asn Gln Phe 
        195                 200                 205             


Gln Thr Glu Val Gly Lys Gln Leu Ile Ser Gly Asn Leu Asp Ala Pro 
    210                 215                 220                 


Glu Gly Gly Leu Asp Ala Met Met Gln Val Ala Ala Cys Pro Glu Glu 
225                 230                 235                 240 


Ile Gly Trp Arg Asn Val Thr Arg Leu Leu Val Phe Ala Thr Asp Asp 
                245                 250                 255     


Gly Phe His Phe Ala Gly Asp Gly Lys Leu Gly Ala Ile Leu Thr Pro 
            260                 265                 270         


Asn Asp Gly Arg Cys His Leu Glu Asp Asn Leu Tyr Lys Arg Ser Asn 
        275                 280                 285             


Glu Phe Asp Tyr Pro Ser Val Gly Gln Leu Ala His Lys Leu Ala Glu 
    290                 295                 300                 


Asn Asn Ile Gln Pro Ile Phe Ala Val Thr Ser Arg Met Val Lys Thr 
305                 310                 315                 320 


Tyr Glu 
        


<210>  7283
<211>  71
<212>  PRT
<213>  Homo Sapiens

<400>  7283

Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser 
1               5                   10                  15      


Leu Gly Cys Gly Arg Pro Arg Ala Pro Thr His Gln Pro Ala Ser Ser 
            20                  25                  30          


Leu Ser Pro Leu Ser Gly Val His Glu Val Gln Gly Gln Gln Leu Pro 
        35                  40                  45              


Gly Met His Arg Val Gly Ala Arg Leu His Leu Val Pro Glu Ala Glu 
    50                  55                  60                  


Leu His Arg Ala Gly Gly Ser 
65                  70      


<210>  7284
<211>  49
<212>  PRT
<213>  Homo Sapiens

<400>  7284

Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser 
1               5                   10                  15      


Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser 
            20                  25                  30          


Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys 
        35                  40                  45              


Leu 
    


<210>  7285
<211>  93
<212>  PRT
<213>  Homo Sapiens

<400>  7285

Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser 
1               5                   10                  15      


Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser 
            20                  25                  30          


Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys 
        35                  40                  45              


Leu Gly Ala Ala Leu Gly Pro Pro Ala His Ala Thr Ala Ala Ser Ser 
    50                  55                  60                  


Pro Arg Arg Arg Ser Arg Val Ala Pro Val Cys Pro Arg Thr Glu Gln 
65                  70                  75                  80  


Gly Gly Gln Ala Pro Glu Leu His Arg Ala Gly Gly Ser 
                85                  90              


<210>  7286
<211>  108
<212>  PRT
<213>  Homo Sapiens

<400>  7286

Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser 
1               5                   10                  15      


Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser 
            20                  25                  30          


Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys 
        35                  40                  45              


Leu Gly Ala Ala Leu Gly Pro Pro Ala His Ala Thr Ala Ala Ser Ser 
    50                  55                  60                  


Pro Arg Arg Arg Ser Arg Val Ala Pro Val Cys Pro Arg Thr Glu Gln 
65                  70                  75                  80  


Gly Gly Gln Ala Pro Gly Gly Asn Tyr Leu Gly Gln Ala Gly Phe Phe 
                85                  90                  95      


Pro Ser Pro Phe Trp Arg Phe Ser Ala Pro Leu Lys 
            100                 105             


<210>  7287
<211>  70
<212>  PRT
<213>  Homo Sapiens

<400>  7287

Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser 
1               5                   10                  15      


Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser 
            20                  25                  30          


Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Pro Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr 
    50                  55                  60                  


Arg Pro Gln Leu Leu Met 
65                  70  


<210>  7288
<211>  712
<212>  PRT
<213>  Homo Sapiens

<400>  7288

Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser 
1               5                   10                  15      


Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser 
            20                  25                  30          


Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Pro Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr 
    50                  55                  60                  


Arg Pro Gln Leu Leu Met Arg Gly Cys Ala Ala Asp Asp Ile Met Asp 
65                  70                  75                  80  


Pro Thr Ser Leu Ala Glu Thr Gln Glu Asp His Asn Gly Gly Gln Lys 
                85                  90                  95      


Gln Leu Ser Pro Gln Lys Val Thr Leu Tyr Leu Arg Pro Gly Phe Gly 
            100                 105                 110         


Ser Phe Val Asp Lys Thr Val Leu Pro Phe Val Asn Thr His Pro Asp 
        115                 120                 125             


Lys Leu Arg Asn Pro Cys Pro Asn Lys Glu Lys Glu Cys Gln Pro Pro 
    130                 135                 140                 


Phe Ala Phe Arg His Val Leu Lys Leu Thr Asn Asn Ser Asn Gln Phe 
145                 150                 155                 160 


Gln Thr Glu Val Gly Lys Gln Leu Ile Ser Gly Asn Leu Asp Ala Pro 
                165                 170                 175     


Glu Gly Gly Leu Asp Ala Met Met Gln Val Ala Ala Cys Pro Glu Glu 
            180                 185                 190         


Ile Gly Trp Arg Asn Val Thr Arg Leu Leu Val Phe Ala Thr Asp Asp 
        195                 200                 205             


Gly Phe His Phe Ala Gly Asp Gly Lys Leu Gly Ala Ile Leu Thr Pro 
    210                 215                 220                 


Asn Asp Gly Arg Cys His Leu Glu Asp Asn Leu Tyr Lys Arg Ser Asn 
225                 230                 235                 240 


Glu Phe Asp Tyr Pro Ser Val Gly Gln Leu Ala His Lys Leu Ala Glu 
                245                 250                 255     


Asn Asn Ile Gln Pro Ile Phe Ala Val Thr Ser Arg Met Val Lys Thr 
            260                 265                 270         


Tyr Glu Lys Leu Thr Glu Ile Ile Pro Lys Ser Ala Val Gly Glu Leu 
        275                 280                 285             


Ser Glu Asp Ser Ser Asn Val Val His Leu Ile Lys Asn Ala Tyr Asn 
    290                 295                 300                 


Lys Leu Ser Ser Arg Val Phe Leu Asp His Asn Ala Leu Pro Asp Thr 
305                 310                 315                 320 


Leu Lys Val Thr Tyr Asp Ser Phe Cys Ser Asn Gly Val Thr His Arg 
                325                 330                 335     


Asn Gln Pro Arg Gly Asp Cys Asp Gly Val Gln Ile Asn Val Pro Ile 
            340                 345                 350         


Thr Phe Gln Val Lys Val Thr Ala Thr Glu Cys Ile Gln Glu Gln Ser 
        355                 360                 365             


Phe Val Ile Arg Ala Leu Gly Phe Thr Asp Ile Val Thr Val Gln Val 
    370                 375                 380                 


Leu Pro Gln Cys Glu Cys Arg Cys Arg Asp Gln Ser Arg Asp Arg Ser 
385                 390                 395                 400 


Leu Cys His Gly Lys Gly Phe Leu Glu Cys Gly Ile Cys Arg Cys Asp 
                405                 410                 415     


Thr Gly Tyr Ile Gly Lys Asn Cys Glu Cys Gln Thr Gln Gly Arg Ser 
            420                 425                 430         


Ser Gln Glu Leu Glu Gly Ser Cys Arg Lys Asp Asn Asn Ser Ile Ile 
        435                 440                 445             


Cys Ser Gly Leu Gly Asp Cys Val Cys Gly Gln Cys Leu Cys His Thr 
    450                 455                 460                 


Ser Asp Val Pro Gly Lys Leu Ile Tyr Gly Gln Tyr Cys Glu Cys Asp 
465                 470                 475                 480 


Thr Ile Asn Cys Glu Arg Tyr Asn Gly Gln Val Cys Gly Gly Pro Gly 
                485                 490                 495     


Arg Gly Leu Cys Phe Cys Gly Lys Cys Arg Cys His Pro Gly Phe Glu 
            500                 505                 510         


Gly Ser Ala Cys Gln Cys Glu Arg Thr Thr Glu Gly Cys Leu Asn Pro 
        515                 520                 525             


Arg Arg Val Glu Cys Ser Gly Arg Gly Arg Cys Arg Cys Asn Val Cys 
    530                 535                 540                 


Glu Cys His Ser Gly Tyr Gln Leu Pro Leu Cys Gln Glu Cys Pro Gly 
545                 550                 555                 560 


Cys Pro Ser Pro Cys Gly Lys Tyr Ile Ser Cys Ala Glu Cys Leu Lys 
                565                 570                 575     


Phe Glu Lys Gly Pro Phe Gly Lys Asn Cys Ser Ala Ala Cys Pro Gly 
            580                 585                 590         


Leu Gln Leu Ser Asn Asn Pro Val Lys Gly Arg Thr Cys Lys Glu Arg 
        595                 600                 605             


Asp Ser Glu Gly Cys Trp Val Ala Tyr Thr Leu Glu Gln Gln Asp Gly 
    610                 615                 620                 


Met Asp Arg Tyr Leu Ile Tyr Val Asp Glu Ser Arg Glu Cys Val Ala 
625                 630                 635                 640 


Gly Pro Asn Ile Ala Ala Ile Val Gly Gly Thr Val Ala Gly Ile Val 
                645                 650                 655     


Leu Ile Gly Ile Leu Leu Leu Val Ile Trp Lys Ala Leu Ile His Leu 
            660                 665                 670         


Ser Asp Leu Arg Glu Tyr Arg Arg Phe Glu Lys Glu Lys Leu Lys Ser 
        675                 680                 685             


Gln Trp Asn Asn Asp Asn Pro Leu Phe Lys Ser Ala Thr Thr Thr Val 
    690                 695                 700                 


Met Asn Pro Lys Phe Ala Glu Ser 
705                 710         


<210>  7289
<211>  120
<212>  PRT
<213>  Homo Sapiens

<400>  7289

Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser 
1               5                   10                  15      


Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser 
            20                  25                  30          


Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Pro Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr 
    50                  55                  60                  


Arg Pro Gln Leu Leu Met Arg Gly Cys Ala Ala Asp Asp Ile Met Asp 
65                  70                  75                  80  


Pro Thr Ser Leu Ala Glu Thr Gln Glu Asp His Asn Gly Gly Gln Lys 
                85                  90                  95      


Gln Leu Ser Pro Gln Lys Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala 
            100                 105                 110         


Ala Ala Phe Asn Val Thr Phe Arg 
        115                 120 


<210>  7290
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  7290

Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser 
1               5                   10                  15      


Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser 
            20                  25                  30          


Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Pro Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr 
    50                  55                  60                  


Arg Pro Gln Leu Leu Met Arg Gly Cys Ala Ala Asp Asp Ile Met Asp 
65                  70                  75                  80  


Pro Thr Ser Leu Ala Glu Thr Gln Glu Asp His Asn Gly Gly Gln Lys 
                85                  90                  95      


Gln Leu Ser Pro Gln Lys Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala 
            100                 105                 110         


Ala Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp 
        115                 120                 125             


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Leu Asp Asp Leu Arg 
    130                 135                 140                 


Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Glu Ile 
145                 150                 155                 160 


<210>  7291
<211>  166
<212>  PRT
<213>  Homo Sapiens

<400>  7291

Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser 
1               5                   10                  15      


Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser 
            20                  25                  30          


Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Pro Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr 
    50                  55                  60                  


Arg Pro Gln Leu Leu Met Arg Gly Cys Ala Ala Asp Asp Ile Met Asp 
65                  70                  75                  80  


Pro Thr Ser Leu Ala Glu Thr Gln Glu Asp His Asn Gly Gly Gln Lys 
                85                  90                  95      


Gln Leu Ser Pro Gln Lys Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala 
            100                 105                 110         


Ala Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp 
        115                 120                 125             


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Leu Asp Asp Leu Arg 
    130                 135                 140                 


Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Glu Ile 
145                 150                 155                 160 


Thr Glu Ser Gly Arg Ile 
                165     


<210>  7292
<211>  769
<212>  PRT
<213>  Homo Sapiens

<400>  7292

Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser 
1               5                   10                  15      


Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser 
            20                  25                  30          


Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Pro Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr 
    50                  55                  60                  


Arg Pro Gln Leu Leu Met Arg Gly Cys Ala Ala Asp Asp Ile Met Asp 
65                  70                  75                  80  


Pro Thr Ser Leu Ala Glu Thr Gln Glu Asp His Asn Gly Gly Gln Lys 
                85                  90                  95      


Gln Leu Ser Pro Gln Lys Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala 
            100                 105                 110         


Ala Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp 
        115                 120                 125             


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Leu Asp Asp Leu Arg 
    130                 135                 140                 


Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Glu Ile 
145                 150                 155                 160 


Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val 
                165                 170                 175     


Leu Pro Phe Val Asn Thr His Pro Asp Lys Leu Arg Asn Pro Cys Pro 
            180                 185                 190         


Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu 
        195                 200                 205             


Lys Leu Thr Asn Asn Ser Asn Gln Phe Gln Thr Glu Val Gly Lys Gln 
    210                 215                 220                 


Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met 
225                 230                 235                 240 


Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr 
                245                 250                 255     


Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp 
            260                 265                 270         


Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu 
        275                 280                 285             


Glu Asp Asn Leu Tyr Lys Arg Ser Asn Glu Phe Asp Tyr Pro Ser Val 
    290                 295                 300                 


Gly Gln Leu Ala His Lys Leu Ala Glu Asn Asn Ile Gln Pro Ile Phe 
305                 310                 315                 320 


Ala Val Thr Ser Arg Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile 
                325                 330                 335     


Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Ser Asn Val 
            340                 345                 350         


Val His Leu Ile Lys Asn Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe 
        355                 360                 365             


Leu Asp His Asn Ala Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser 
    370                 375                 380                 


Phe Cys Ser Asn Gly Val Thr His Arg Asn Gln Pro Arg Gly Asp Cys 
385                 390                 395                 400 


Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr 
                405                 410                 415     


Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Val Ile Arg Ala Leu Gly 
            420                 425                 430         


Phe Thr Asp Ile Val Thr Val Gln Val Leu Pro Gln Cys Glu Cys Arg 
        435                 440                 445             


Cys Arg Asp Gln Ser Arg Asp Arg Ser Leu Cys His Gly Lys Gly Phe 
    450                 455                 460                 


Leu Glu Cys Gly Ile Cys Arg Cys Asp Thr Gly Tyr Ile Gly Lys Asn 
465                 470                 475                 480 


Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser 
                485                 490                 495     


Cys Arg Lys Asp Asn Asn Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys 
            500                 505                 510         


Val Cys Gly Gln Cys Leu Cys His Thr Ser Asp Val Pro Gly Lys Leu 
        515                 520                 525             


Ile Tyr Gly Gln Tyr Cys Glu Cys Asp Thr Ile Asn Cys Glu Arg Tyr 
    530                 535                 540                 


Asn Gly Gln Val Cys Gly Gly Pro Gly Arg Gly Leu Cys Phe Cys Gly 
545                 550                 555                 560 


Lys Cys Arg Cys His Pro Gly Phe Glu Gly Ser Ala Cys Gln Cys Glu 
                565                 570                 575     


Arg Thr Thr Glu Gly Cys Leu Asn Pro Arg Arg Val Glu Cys Ser Gly 
            580                 585                 590         


Arg Gly Arg Cys Arg Cys Asn Val Cys Glu Cys His Ser Gly Tyr Gln 
        595                 600                 605             


Leu Pro Leu Cys Gln Glu Cys Pro Gly Cys Pro Ser Pro Cys Gly Lys 
    610                 615                 620                 


Tyr Ile Ser Cys Ala Glu Cys Leu Lys Phe Glu Lys Gly Pro Phe Gly 
625                 630                 635                 640 


Lys Asn Cys Ser Ala Ala Cys Pro Gly Leu Gln Leu Ser Asn Asn Pro 
                645                 650                 655     


Val Lys Gly Arg Thr Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp Val 
            660                 665                 670         


Ala Tyr Thr Leu Glu Gln Gln Asp Gly Met Asp Arg Tyr Leu Ile Tyr 
        675                 680                 685             


Val Asp Glu Ser Arg Glu Cys Val Ala Gly Pro Asn Ile Ala Ala Ile 
    690                 695                 700                 


Val Gly Gly Thr Val Ala Gly Ile Val Leu Ile Gly Ile Leu Leu Leu 
705                 710                 715                 720 


Val Ile Trp Lys Ala Leu Ile His Leu Ser Asp Leu Arg Glu Tyr Arg 
                725                 730                 735     


Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro 
            740                 745                 750         


Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu 
        755                 760                 765             


Ser 
    


<210>  7293
<211>  769
<212>  PRT
<213>  Homo Sapiens

<400>  7293

Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser 
1               5                   10                  15      


Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser 
            20                  25                  30          


Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Pro Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr 
    50                  55                  60                  


Arg Pro Gln Leu Leu Met Arg Gly Cys Ala Ala Asp Asp Ile Met Asp 
65                  70                  75                  80  


Pro Thr Ser Leu Ala Glu Thr Gln Glu Asp His Asn Gly Gly Gln Lys 
                85                  90                  95      


Gln Leu Ser Pro Gln Lys Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala 
            100                 105                 110         


Ala Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp 
        115                 120                 125             


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Leu Asp Asp Leu Arg 
    130                 135                 140                 


Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Glu Ile 
145                 150                 155                 160 


Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val 
                165                 170                 175     


Leu Pro Phe Val Asn Thr His Pro Asp Lys Leu Arg Asn Pro Cys Pro 
            180                 185                 190         


Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu 
        195                 200                 205             


Lys Leu Thr Asn Asn Ser Asn Gln Phe Gln Thr Glu Val Gly Lys Gln 
    210                 215                 220                 


Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met 
225                 230                 235                 240 


Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr 
                245                 250                 255     


Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp 
            260                 265                 270         


Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu 
        275                 280                 285             


Glu Asp Asn Leu Tyr Lys Arg Ser Asn Glu Phe Asp Tyr Pro Ser Val 
    290                 295                 300                 


Gly Gln Leu Ala His Lys Leu Ala Glu Asn Asn Ile Gln Pro Ile Phe 
305                 310                 315                 320 


Ala Val Thr Ser Arg Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile 
                325                 330                 335     


Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Ser Asn Val 
            340                 345                 350         


Val His Leu Ile Lys Asn Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe 
        355                 360                 365             


Leu Asp His Asn Ala Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser 
    370                 375                 380                 


Phe Cys Ser Asn Gly Val Thr His Arg Asn Gln Pro Arg Gly Asp Cys 
385                 390                 395                 400 


Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr 
                405                 410                 415     


Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Val Ile Arg Ala Leu Gly 
            420                 425                 430         


Phe Thr Asp Ile Val Thr Val Gln Val Leu Pro Gln Cys Glu Cys Arg 
        435                 440                 445             


Cys Arg Asp Gln Ser Arg Asp Arg Ser Leu Cys His Gly Lys Gly Phe 
    450                 455                 460                 


Leu Glu Cys Gly Ile Cys Arg Cys Asp Thr Gly Tyr Ile Gly Lys Asn 
465                 470                 475                 480 


Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser 
                485                 490                 495     


Cys Arg Lys Asp Asn Asn Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys 
            500                 505                 510         


Val Cys Gly Gln Cys Leu Cys His Thr Ser Asp Val Pro Gly Lys Leu 
        515                 520                 525             


Ile Tyr Gly Gln Tyr Cys Glu Cys Asp Thr Ile Asn Cys Glu Arg Tyr 
    530                 535                 540                 


Asn Gly Gln Val Cys Gly Gly Pro Gly Arg Gly Leu Cys Phe Cys Gly 
545                 550                 555                 560 


Lys Cys Arg Cys His Pro Gly Phe Glu Gly Ser Ala Cys Gln Cys Glu 
                565                 570                 575     


Arg Thr Thr Glu Gly Cys Leu Asn Pro Arg Arg Val Glu Cys Ser Gly 
            580                 585                 590         


Arg Gly Arg Cys Arg Cys Asn Val Cys Glu Cys His Ser Gly Tyr Gln 
        595                 600                 605             


Leu Pro Leu Cys Gln Glu Cys Pro Gly Cys Pro Ser Pro Cys Gly Lys 
    610                 615                 620                 


Tyr Ile Ser Cys Ala Glu Cys Leu Lys Phe Glu Lys Gly Pro Phe Gly 
625                 630                 635                 640 


Lys Asn Cys Ser Ala Ala Cys Pro Gly Leu Gln Leu Ser Asn Asn Pro 
                645                 650                 655     


Val Lys Gly Arg Thr Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp Val 
            660                 665                 670         


Ala Tyr Thr Leu Glu Gln Gln Asp Gly Met Asp Arg Tyr Leu Ile Tyr 
        675                 680                 685             


Val Asp Glu Ser Arg Glu Cys Val Ala Gly Pro Asn Ile Ala Ala Ile 
    690                 695                 700                 


Val Gly Gly Thr Val Ala Gly Ile Val Leu Ile Gly Ile Leu Leu Leu 
705                 710                 715                 720 


Val Ile Trp Lys Ala Leu Ile His Leu Ser Asp Leu Arg Glu Tyr Arg 
                725                 730                 735     


Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro 
            740                 745                 750         


Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu 
        755                 760                 765             


Ser 
    


<210>  7294
<211>  769
<212>  PRT
<213>  Homo Sapiens

<400>  7294

Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser 
1               5                   10                  15      


Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser 
            20                  25                  30          


Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Pro Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr 
    50                  55                  60                  


Arg Pro Gln Leu Leu Met Arg Gly Cys Ala Ala Asp Asp Ile Met Asp 
65                  70                  75                  80  


Pro Thr Ser Leu Ala Glu Thr Gln Glu Asp His Asn Gly Gly Gln Lys 
                85                  90                  95      


Gln Leu Ser Pro Gln Lys Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala 
            100                 105                 110         


Ala Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp 
        115                 120                 125             


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Leu Asp Asp Leu Arg 
    130                 135                 140                 


Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Glu Ile 
145                 150                 155                 160 


Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val 
                165                 170                 175     


Leu Pro Phe Val Asn Thr His Pro Asp Lys Leu Arg Asn Pro Cys Pro 
            180                 185                 190         


Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu 
        195                 200                 205             


Lys Leu Thr Asn Asn Ser Asn Gln Phe Gln Thr Glu Val Gly Lys Gln 
    210                 215                 220                 


Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met 
225                 230                 235                 240 


Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr 
                245                 250                 255     


Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp 
            260                 265                 270         


Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu 
        275                 280                 285             


Glu Asp Asn Leu Tyr Lys Arg Ser Asn Glu Phe Asp Tyr Pro Ser Val 
    290                 295                 300                 


Gly Gln Leu Ala His Lys Leu Ala Glu Asn Asn Ile Gln Pro Ile Phe 
305                 310                 315                 320 


Ala Val Thr Ser Arg Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile 
                325                 330                 335     


Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Ser Asn Val 
            340                 345                 350         


Val His Leu Ile Lys Asn Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe 
        355                 360                 365             


Leu Asp His Asn Ala Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser 
    370                 375                 380                 


Phe Cys Ser Asn Gly Val Thr His Arg Asn Gln Pro Arg Gly Asp Cys 
385                 390                 395                 400 


Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr 
                405                 410                 415     


Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Val Ile Arg Ala Leu Gly 
            420                 425                 430         


Phe Thr Asp Ile Val Thr Val Gln Val Leu Pro Gln Cys Glu Cys Arg 
        435                 440                 445             


Cys Arg Asp Gln Ser Arg Asp Arg Ser Leu Cys His Gly Lys Gly Phe 
    450                 455                 460                 


Leu Glu Cys Gly Ile Cys Arg Cys Asp Thr Gly Tyr Ile Gly Lys Asn 
465                 470                 475                 480 


Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser 
                485                 490                 495     


Cys Arg Lys Asp Asn Asn Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys 
            500                 505                 510         


Val Cys Gly Gln Cys Leu Cys His Thr Ser Asp Val Pro Gly Lys Leu 
        515                 520                 525             


Ile Tyr Gly Gln Tyr Cys Glu Cys Asp Thr Ile Asn Cys Glu Arg Tyr 
    530                 535                 540                 


Asn Gly Gln Val Cys Gly Gly Pro Gly Arg Gly Leu Cys Phe Cys Gly 
545                 550                 555                 560 


Lys Cys Arg Cys His Pro Gly Phe Glu Gly Ser Ala Cys Gln Cys Glu 
                565                 570                 575     


Arg Thr Thr Glu Gly Cys Leu Asn Pro Arg Arg Val Glu Cys Ser Gly 
            580                 585                 590         


Arg Gly Arg Cys Arg Cys Asn Val Cys Glu Cys His Ser Gly Tyr Gln 
        595                 600                 605             


Leu Pro Leu Cys Gln Glu Cys Pro Gly Cys Pro Ser Pro Cys Gly Lys 
    610                 615                 620                 


Tyr Ile Ser Cys Ala Glu Cys Leu Lys Phe Glu Lys Gly Pro Phe Gly 
625                 630                 635                 640 


Lys Asn Cys Ser Ala Ala Cys Pro Gly Leu Gln Leu Ser Asn Asn Pro 
                645                 650                 655     


Val Lys Gly Arg Thr Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp Val 
            660                 665                 670         


Ala Tyr Thr Leu Glu Gln Gln Asp Gly Met Asp Arg Tyr Leu Ile Tyr 
        675                 680                 685             


Val Asp Glu Ser Arg Glu Cys Val Ala Gly Pro Asn Ile Ala Ala Ile 
    690                 695                 700                 


Val Gly Gly Thr Val Ala Gly Ile Val Leu Ile Gly Ile Leu Leu Leu 
705                 710                 715                 720 


Val Ile Trp Lys Ala Leu Ile His Leu Ser Asp Leu Arg Glu Tyr Arg 
                725                 730                 735     


Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro 
            740                 745                 750         


Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu 
        755                 760                 765             


Ser 
    


<210>  7295
<211>  769
<212>  PRT
<213>  Homo Sapiens

<400>  7295

Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser 
1               5                   10                  15      


Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser 
            20                  25                  30          


Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Pro Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr 
    50                  55                  60                  


Arg Pro Gln Leu Leu Met Arg Gly Cys Ala Ala Asp Asp Ile Met Asp 
65                  70                  75                  80  


Pro Thr Ser Leu Ala Glu Thr Gln Glu Asp His Asn Gly Gly Gln Lys 
                85                  90                  95      


Gln Leu Ser Pro Gln Lys Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala 
            100                 105                 110         


Ala Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp 
        115                 120                 125             


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Leu Asp Asp Leu Arg 
    130                 135                 140                 


Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Glu Ile 
145                 150                 155                 160 


Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val 
                165                 170                 175     


Leu Pro Phe Val Asn Thr His Pro Asp Lys Leu Arg Asn Pro Cys Pro 
            180                 185                 190         


Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu 
        195                 200                 205             


Lys Leu Thr Asn Asn Ser Asn Gln Phe Gln Thr Glu Val Gly Lys Gln 
    210                 215                 220                 


Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met 
225                 230                 235                 240 


Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr 
                245                 250                 255     


Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp 
            260                 265                 270         


Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu 
        275                 280                 285             


Glu Asp Asn Leu Tyr Lys Arg Ser Asn Glu Phe Asp Tyr Pro Ser Val 
    290                 295                 300                 


Gly Gln Leu Ala His Lys Leu Ala Glu Asn Asn Ile Gln Pro Ile Phe 
305                 310                 315                 320 


Ala Val Thr Ser Arg Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile 
                325                 330                 335     


Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Ser Asn Val 
            340                 345                 350         


Val His Leu Ile Lys Asn Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe 
        355                 360                 365             


Leu Asp His Asn Ala Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser 
    370                 375                 380                 


Phe Cys Ser Asn Gly Val Thr His Arg Asn Gln Pro Arg Gly Asp Cys 
385                 390                 395                 400 


Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr 
                405                 410                 415     


Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Val Ile Arg Ala Leu Gly 
            420                 425                 430         


Phe Thr Asp Ile Val Thr Val Gln Val Leu Pro Gln Cys Glu Cys Arg 
        435                 440                 445             


Cys Arg Asp Gln Ser Arg Asp Arg Ser Leu Cys His Gly Lys Gly Phe 
    450                 455                 460                 


Leu Glu Cys Gly Ile Cys Arg Cys Asp Thr Gly Tyr Ile Gly Lys Asn 
465                 470                 475                 480 


Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser 
                485                 490                 495     


Cys Arg Lys Asp Asn Asn Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys 
            500                 505                 510         


Val Cys Gly Gln Cys Leu Cys His Thr Ser Asp Val Pro Gly Lys Leu 
        515                 520                 525             


Ile Tyr Gly Gln Tyr Cys Glu Cys Asp Thr Ile Asn Cys Glu Arg Tyr 
    530                 535                 540                 


Asn Gly Gln Val Cys Gly Gly Pro Gly Arg Gly Leu Cys Phe Cys Gly 
545                 550                 555                 560 


Lys Cys Arg Cys His Pro Gly Phe Glu Gly Ser Ala Cys Gln Cys Glu 
                565                 570                 575     


Arg Thr Thr Glu Gly Cys Leu Asn Pro Arg Arg Val Glu Cys Ser Gly 
            580                 585                 590         


Arg Gly Arg Cys Arg Cys Asn Val Cys Glu Cys His Ser Gly Tyr Gln 
        595                 600                 605             


Leu Pro Leu Cys Gln Glu Cys Pro Gly Cys Pro Ser Pro Cys Gly Lys 
    610                 615                 620                 


Tyr Ile Ser Cys Ala Glu Cys Leu Lys Phe Glu Lys Gly Pro Phe Gly 
625                 630                 635                 640 


Lys Asn Cys Ser Ala Ala Cys Pro Gly Leu Gln Leu Ser Asn Asn Pro 
                645                 650                 655     


Val Lys Gly Arg Thr Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp Val 
            660                 665                 670         


Ala Tyr Thr Leu Glu Gln Gln Asp Gly Met Asp Arg Tyr Leu Ile Tyr 
        675                 680                 685             


Val Asp Glu Ser Arg Glu Cys Val Ala Gly Pro Asn Ile Ala Ala Ile 
    690                 695                 700                 


Val Gly Gly Thr Val Ala Gly Ile Val Leu Ile Gly Ile Leu Leu Leu 
705                 710                 715                 720 


Val Ile Trp Lys Ala Leu Ile His Leu Ser Asp Leu Arg Glu Tyr Arg 
                725                 730                 735     


Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro 
            740                 745                 750         


Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu 
        755                 760                 765             


Ser 
    


<210>  7296
<211>  769
<212>  PRT
<213>  Homo Sapiens

<400>  7296

Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser 
1               5                   10                  15      


Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser 
            20                  25                  30          


Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Pro Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr 
    50                  55                  60                  


Arg Pro Gln Leu Leu Met Arg Gly Cys Ala Ala Asp Asp Ile Met Asp 
65                  70                  75                  80  


Pro Thr Ser Leu Ala Glu Thr Gln Glu Asp His Asn Gly Gly Gln Lys 
                85                  90                  95      


Gln Leu Ser Pro Gln Lys Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala 
            100                 105                 110         


Ala Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp 
        115                 120                 125             


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Leu Asp Asp Leu Arg 
    130                 135                 140                 


Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Glu Ile 
145                 150                 155                 160 


Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val 
                165                 170                 175     


Leu Pro Phe Val Asn Thr His Pro Asp Lys Leu Arg Asn Pro Cys Pro 
            180                 185                 190         


Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu 
        195                 200                 205             


Lys Leu Thr Asn Asn Ser Asn Gln Phe Gln Thr Glu Val Gly Lys Gln 
    210                 215                 220                 


Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met 
225                 230                 235                 240 


Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr 
                245                 250                 255     


Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp 
            260                 265                 270         


Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu 
        275                 280                 285             


Glu Asp Asn Leu Tyr Lys Arg Ser Asn Glu Phe Asp Tyr Pro Ser Val 
    290                 295                 300                 


Gly Gln Leu Ala His Lys Leu Ala Glu Asn Asn Ile Gln Pro Ile Phe 
305                 310                 315                 320 


Ala Val Thr Ser Arg Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile 
                325                 330                 335     


Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Ser Asn Val 
            340                 345                 350         


Val His Leu Ile Lys Asn Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe 
        355                 360                 365             


Leu Asp His Asn Ala Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser 
    370                 375                 380                 


Phe Cys Ser Asn Gly Val Thr His Arg Asn Gln Pro Arg Gly Asp Cys 
385                 390                 395                 400 


Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr 
                405                 410                 415     


Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Val Ile Arg Ala Leu Gly 
            420                 425                 430         


Phe Thr Asp Ile Val Thr Val Gln Val Leu Pro Gln Cys Glu Cys Arg 
        435                 440                 445             


Cys Arg Asp Gln Ser Arg Asp Arg Ser Leu Cys His Gly Lys Gly Phe 
    450                 455                 460                 


Leu Glu Cys Gly Ile Cys Arg Cys Asp Thr Gly Tyr Ile Gly Lys Asn 
465                 470                 475                 480 


Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser 
                485                 490                 495     


Cys Arg Lys Asp Asn Asn Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys 
            500                 505                 510         


Val Cys Gly Gln Cys Leu Cys His Thr Ser Asp Val Pro Gly Lys Leu 
        515                 520                 525             


Ile Tyr Gly Gln Tyr Cys Glu Cys Asp Thr Ile Asn Cys Glu Arg Tyr 
    530                 535                 540                 


Asn Gly Gln Val Cys Gly Gly Pro Gly Arg Gly Leu Cys Phe Cys Gly 
545                 550                 555                 560 


Lys Cys Arg Cys His Pro Gly Phe Glu Gly Ser Ala Cys Gln Cys Glu 
                565                 570                 575     


Arg Thr Thr Glu Gly Cys Leu Asn Pro Arg Arg Val Glu Cys Ser Gly 
            580                 585                 590         


Arg Gly Arg Cys Arg Cys Asn Val Cys Glu Cys His Ser Gly Tyr Gln 
        595                 600                 605             


Leu Pro Leu Cys Gln Glu Cys Pro Gly Cys Pro Ser Pro Cys Gly Lys 
    610                 615                 620                 


Tyr Ile Ser Cys Ala Glu Cys Leu Lys Phe Glu Lys Gly Pro Phe Gly 
625                 630                 635                 640 


Lys Asn Cys Ser Ala Ala Cys Pro Gly Leu Gln Leu Ser Asn Asn Pro 
                645                 650                 655     


Val Lys Gly Arg Thr Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp Val 
            660                 665                 670         


Ala Tyr Thr Leu Glu Gln Gln Asp Gly Met Asp Arg Tyr Leu Ile Tyr 
        675                 680                 685             


Val Asp Glu Ser Arg Glu Cys Val Ala Gly Pro Asn Ile Ala Ala Ile 
    690                 695                 700                 


Val Gly Gly Thr Val Ala Gly Ile Val Leu Ile Gly Ile Leu Leu Leu 
705                 710                 715                 720 


Val Ile Trp Lys Ala Leu Ile His Leu Ser Asp Leu Arg Glu Tyr Arg 
                725                 730                 735     


Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro 
            740                 745                 750         


Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu 
        755                 760                 765             


Ser 
    


<210>  7297
<211>  37
<212>  PRT
<213>  Homo Sapiens

<400>  7297

Met Arg Gly Cys Ala Ala Asp Asp Ile Met Asp Pro Thr Ser Leu Ala 
1               5                   10                  15      


Glu Thr Gln Glu Asp His Asn Gly Gly Gln Lys Gln Leu Ser Pro Gln 
            20                  25                  30          


Lys Val Thr Leu Tyr 
        35          


<210>  7298
<211>  49
<212>  PRT
<213>  Homo Sapiens

<400>  7298

Met Arg Gly Cys Ala Ala Asp Asp Ile Met Asp Pro Thr Ser Leu Ala 
1               5                   10                  15      


Glu Thr Gln Glu Asp His Asn Gly Gly Gln Lys Gln Leu Ser Pro Gln 
            20                  25                  30          


Lys Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala Ala Ala Phe Asn Val 
        35                  40                  45              


Thr 
    


<210>  7299
<211>  35
<212>  PRT
<213>  Homo Sapiens

<400>  7299

Leu Lys Ser Cys Met Gly Leu Lys Ile Gly Asp Thr Val Arg Trp Ala 
1               5                   10                  15      


Gly Gln Gly Leu Cys Pro Gly Ala Ser Val Gly Thr Gln Pro Pro Phe 
            20                  25                  30          


Phe Leu Leu 
        35  


<210>  7300
<211>  788
<212>  PRT
<213>  Homo Sapiens

<400>  7300

Met Arg Ala Arg Pro Arg Pro Arg Pro Leu Trp Ala Thr Val Leu Ala 
1               5                   10                  15      


Leu Gly Ala Leu Ala Gly Val Gly Val Gly Gly Pro Asn Ile Cys Thr 
            20                  25                  30          


Thr Arg Gly Val Ser Ser Cys Gln Gln Cys Leu Ala Val Ser Pro Met 
        35                  40                  45              


Cys Ala Trp Cys Ser Asp Glu Ala Leu Pro Leu Gly Ser Pro Arg Cys 
    50                  55                  60                  


Asp Leu Lys Glu Asn Leu Leu Lys Asp Asn Cys Ala Pro Glu Ser Ile 
65                  70                  75                  80  


Glu Phe Pro Val Ser Glu Ala Arg Val Leu Glu Asp Arg Pro Leu Ser 
                85                  90                  95      


Asp Lys Gly Ser Gly Asp Ser Ser Gln Val Thr Gln Val Ser Pro Gln 
            100                 105                 110         


Arg Ile Ala Leu Arg Leu Arg Pro Asp Asp Ser Lys Asn Phe Ser Ile 
        115                 120                 125             


Gln Val Arg Gln Val Glu Asp Tyr Pro Val Asp Ile Tyr Tyr Leu Met 
    130                 135                 140                 


Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Trp Ser Ile Gln Asn Leu 
145                 150                 155                 160 


Gly Thr Lys Leu Ala Thr Gln Met Arg Lys Leu Thr Ser Asn Leu Arg 
                165                 170                 175     


Ile Gly Phe Gly Ala Phe Val Asp Lys Pro Val Ser Pro Tyr Met Tyr 
            180                 185                 190         


Ile Ser Pro Pro Glu Ala Leu Glu Asn Pro Cys Tyr Asp Met Lys Thr 
        195                 200                 205             


Thr Cys Leu Pro Met Phe Gly Tyr Lys His Val Leu Thr Leu Thr Asp 
    210                 215                 220                 


Gln Val Thr Arg Phe Asn Glu Glu Val Lys Lys Gln Ser Val Ser Arg 
225                 230                 235                 240 


Asn Arg Asp Ala Pro Glu Gly Gly Phe Asp Ala Ile Met Gln Ala Thr 
                245                 250                 255     


Val Cys Asp Glu Lys Ile Gly Trp Arg Asn Asp Ala Ser His Leu Leu 
            260                 265                 270         


Val Phe Thr Thr Asp Ala Lys Thr His Ile Ala Leu Asp Gly Arg Leu 
        275                 280                 285             


Ala Gly Ile Val Gln Pro Asn Asp Gly Gln Cys His Val Gly Ser Asp 
    290                 295                 300                 


Asn His Tyr Ser Ala Ser Thr Thr Met Asp Tyr Pro Ser Leu Gly Leu 
305                 310                 315                 320 


Met Thr Glu Lys Leu Ser Gln Lys Asn Ile Asn Leu Ile Phe Ala Val 
                325                 330                 335     


Thr Glu Asn Val Val Asn Leu Tyr Gln Asn Tyr Ser Glu Leu Ile Pro 
            340                 345                 350         


Gly Thr Thr Val Gly Val Leu Ser Met Asp Ser Ser Asn Val Leu Gln 
        355                 360                 365             


Leu Ile Val Asp Ala Tyr Gly Lys Ile Arg Ser Lys Val Glu Leu Glu 
    370                 375                 380                 


Val Arg Asp Leu Pro Glu Glu Leu Ser Leu Ser Phe Asn Ala Thr Cys 
385                 390                 395                 400 


Leu Asn Asn Glu Val Ile Pro Gly Leu Lys Ser Cys Met Gly Leu Lys 
                405                 410                 415     


Ile Gly Asp Thr Val Ser Phe Ser Ile Glu Ala Lys Val Arg Gly Cys 
            420                 425                 430         


Pro Gln Glu Lys Glu Lys Ser Phe Thr Ile Lys Pro Val Gly Phe Lys 
        435                 440                 445             


Asp Ser Leu Ile Val Gln Val Thr Phe Asp Cys Asp Cys Ala Cys Gln 
    450                 455                 460                 


Ala Gln Ala Glu Pro Asn Ser His Arg Cys Asn Asn Gly Asn Gly Thr 
465                 470                 475                 480 


Phe Glu Cys Gly Val Cys Arg Cys Gly Pro Gly Trp Leu Gly Ser Gln 
                485                 490                 495     


Cys Glu Cys Ser Glu Glu Asp Tyr Arg Pro Ser Gln Gln Asp Glu Cys 
            500                 505                 510         


Ser Pro Arg Glu Gly Gln Pro Val Cys Ser Gln Arg Gly Glu Cys Leu 
        515                 520                 525             


Cys Gly Gln Cys Val Cys His Ser Ser Asp Phe Gly Lys Ile Thr Gly 
    530                 535                 540                 


Lys Tyr Cys Glu Cys Asp Asp Phe Ser Cys Val Arg Tyr Lys Gly Glu 
545                 550                 555                 560 


Met Cys Ser Gly His Gly Gln Cys Ser Cys Gly Asp Cys Leu Cys Asp 
                565                 570                 575     


Ser Asp Trp Thr Gly Tyr Tyr Cys Asn Cys Thr Thr Arg Thr Asp Thr 
            580                 585                 590         


Cys Met Ser Ser Asn Gly Leu Leu Cys Ser Gly Arg Gly Lys Cys Glu 
        595                 600                 605             


Cys Gly Ser Cys Val Cys Ile Gln Pro Gly Ser Tyr Gly Asp Thr Cys 
    610                 615                 620                 


Glu Lys Cys Pro Thr Cys Pro Asp Ala Cys Thr Phe Lys Lys Glu Cys 
625                 630                 635                 640 


Val Glu Cys Lys Lys Phe Asp Arg Gly Ala Leu His Asp Glu Asn Thr 
                645                 650                 655     


Cys Asn Arg Tyr Cys Arg Asp Glu Ile Glu Ser Val Lys Glu Leu Lys 
            660                 665                 670         


Asp Thr Gly Lys Asp Ala Val Asn Cys Thr Tyr Lys Asn Glu Asp Asp 
        675                 680                 685             


Cys Val Val Arg Phe Gln Tyr Tyr Glu Asp Ser Ser Gly Lys Ser Ile 
    690                 695                 700                 


Leu Tyr Val Val Glu Glu Pro Glu Cys Pro Lys Gly Pro Asp Ile Leu 
705                 710                 715                 720 


Val Val Leu Leu Ser Val Met Gly Ala Ile Leu Leu Ile Gly Leu Ala 
                725                 730                 735     


Ala Leu Leu Ile Trp Lys Leu Leu Ile Thr Ile His Asp Arg Lys Glu 
            740                 745                 750         


Phe Ala Lys Phe Glu Glu Glu Arg Ala Arg Ala Lys Trp Asp Thr Ala 
        755                 760                 765             


Asn Asn Pro Leu Tyr Lys Glu Ala Thr Ser Thr Phe Thr Asn Ile Thr 
    770                 775                 780                 


Tyr Arg Gly Thr 
785             


<210>  7301
<211>  443
<212>  PRT
<213>  Homo Sapiens

<400>  7301

Met Arg Ala Arg Pro Arg Pro Arg Pro Leu Trp Ala Thr Val Leu Ala 
1               5                   10                  15      


Leu Gly Ala Leu Ala Gly Val Gly Val Gly Gly Pro Asn Ile Cys Thr 
            20                  25                  30          


Thr Arg Gly Val Ser Ser Cys Gln Gln Cys Leu Ala Val Ser Pro Met 
        35                  40                  45              


Cys Ala Trp Cys Ser Asp Glu Ala Leu Pro Leu Gly Ser Pro Arg Cys 
    50                  55                  60                  


Asp Leu Lys Glu Asn Leu Leu Lys Asp Asn Cys Ala Pro Glu Ser Ile 
65                  70                  75                  80  


Glu Phe Pro Val Ser Glu Ala Arg Val Leu Glu Asp Arg Pro Leu Ser 
                85                  90                  95      


Asp Lys Gly Ser Gly Asp Ser Ser Gln Val Thr Gln Val Ser Pro Gln 
            100                 105                 110         


Arg Ile Ala Leu Arg Leu Arg Pro Asp Asp Ser Lys Asn Phe Ser Ile 
        115                 120                 125             


Gln Val Arg Gln Val Glu Asp Tyr Pro Val Asp Ile Tyr Tyr Leu Met 
    130                 135                 140                 


Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Trp Ser Ile Gln Asn Leu 
145                 150                 155                 160 


Gly Thr Lys Leu Ala Thr Gln Met Arg Lys Leu Thr Ser Asn Leu Arg 
                165                 170                 175     


Ile Gly Phe Gly Ala Phe Val Asp Lys Pro Val Ser Pro Tyr Met Tyr 
            180                 185                 190         


Ile Ser Pro Pro Glu Ala Leu Glu Asn Pro Cys Tyr Asp Met Lys Thr 
        195                 200                 205             


Thr Cys Leu Pro Met Phe Gly Tyr Lys His Val Leu Thr Leu Thr Asp 
    210                 215                 220                 


Gln Val Thr Arg Phe Asn Glu Glu Val Lys Lys Gln Ser Val Ser Arg 
225                 230                 235                 240 


Asn Arg Asp Ala Pro Glu Gly Gly Phe Asp Ala Ile Met Gln Ala Thr 
                245                 250                 255     


Val Cys Asp Glu Lys Ile Gly Trp Arg Asn Asp Ala Ser His Leu Leu 
            260                 265                 270         


Val Phe Thr Thr Asp Ala Lys Thr His Ile Ala Leu Asp Gly Arg Leu 
        275                 280                 285             


Ala Gly Ile Val Gln Pro Asn Asp Gly Gln Cys His Val Gly Ser Asp 
    290                 295                 300                 


Asn His Tyr Ser Ala Ser Thr Thr Met Asp Tyr Pro Ser Leu Gly Leu 
305                 310                 315                 320 


Met Thr Glu Lys Leu Ser Gln Lys Asn Ile Asn Leu Ile Phe Ala Val 
                325                 330                 335     


Thr Glu Asn Val Val Asn Leu Tyr Gln Asn Tyr Ser Glu Leu Ile Pro 
            340                 345                 350         


Gly Thr Thr Val Gly Val Leu Ser Met Asp Ser Ser Asn Val Leu Gln 
        355                 360                 365             


Leu Ile Val Asp Ala Tyr Gly Lys Ile Arg Ser Lys Val Glu Leu Glu 
    370                 375                 380                 


Val Arg Asp Leu Pro Glu Glu Leu Ser Leu Ser Phe Asn Ala Thr Cys 
385                 390                 395                 400 


Leu Asn Asn Glu Val Ile Pro Gly Leu Lys Ser Cys Met Gly Leu Lys 
                405                 410                 415     


Ile Gly Asp Thr Val Arg Trp Ala Gly Gln Gly Leu Cys Pro Gly Ala 
            420                 425                 430         


Ser Val Gly Thr Gln Pro Pro Phe Phe Leu Leu 
        435                 440             


<210>  7302
<211>  89
<212>  PRT
<213>  Homo Sapiens

<400>  7302

Met Val Ala Leu Pro Met Val Leu Val Leu Leu Leu Val Leu Ser Arg 
1               5                   10                  15      


Gly Glu Ser Glu Leu Asp Ala Lys Ile Pro Ser Thr Gly Asp Ala Thr 
            20                  25                  30          


Glu Trp Arg Asn Pro His Leu Ser Met Leu Gly Ser Cys Gln Pro Ala 
        35                  40                  45              


Pro Ser Cys Gln Lys Cys Ile Leu Ser His Pro Ser Cys Ala Trp Cys 
    50                  55                  60                  


Lys Gln Leu Asn Phe Thr Ala Ser Gly Glu Ala Glu Ala Arg Arg Cys 
65                  70                  75                  80  


Ala Arg Arg Glu Glu Leu Leu Ala Arg 
                85                  


<210>  7303
<211>  93
<212>  PRT
<213>  Homo Sapiens

<400>  7303

Met Val Ala Leu Pro Met Val Leu Val Leu Leu Leu Val Leu Ser Arg 
1               5                   10                  15      


Gly Glu Ser Glu Leu Asp Ala Lys Ile Pro Ser Thr Gly Asp Ala Thr 
            20                  25                  30          


Glu Trp Arg Asn Pro His Leu Ser Met Leu Gly Ser Cys Gln Pro Ala 
        35                  40                  45              


Pro Ser Cys Gln Lys Cys Ile Leu Ser His Pro Ser Cys Ala Trp Cys 
    50                  55                  60                  


Lys Gln Leu Asn Phe Thr Ala Ser Gly Glu Ala Glu Ala Arg Arg Cys 
65                  70                  75                  80  


Ala Arg Arg Glu Glu Leu Leu Ala Arg Gly Cys Pro Leu 
                85                  90              


<210>  7304
<211>  158
<212>  PRT
<213>  Homo Sapiens

<400>  7304

Met Val Ala Leu Pro Met Val Leu Val Leu Leu Leu Val Leu Ser Arg 
1               5                   10                  15      


Gly Glu Ser Glu Leu Asp Ala Lys Ile Pro Ser Thr Gly Asp Ala Thr 
            20                  25                  30          


Glu Trp Arg Asn Pro His Leu Ser Met Leu Gly Ser Cys Gln Pro Ala 
        35                  40                  45              


Pro Ser Cys Gln Lys Cys Ile Leu Ser His Pro Ser Cys Ala Trp Cys 
    50                  55                  60                  


Lys Gln Leu Asn Phe Thr Ala Ser Gly Glu Ala Glu Ala Arg Arg Cys 
65                  70                  75                  80  


Ala Arg Arg Glu Glu Leu Leu Ala Arg Gly Cys Pro Leu Glu Glu Leu 
                85                  90                  95      


Glu Glu Pro Arg Gly Gln Gln Glu Val Leu Gln Asp Gln Pro Leu Ser 
            100                 105                 110         


Gln Gly Ala Arg Gly Glu Gly Ala Thr Gln Leu Ala Pro Gln Arg Val 
        115                 120                 125             


Arg Val Thr Leu Arg Pro Gly Glu Pro Gln Gln Leu Gln Val Arg Phe 
    130                 135                 140                 


Leu Arg Ala Glu Gly Tyr Pro Val Asp Leu Tyr Tyr Leu Met 
145                 150                 155             


<210>  7305
<211>  798
<212>  PRT
<213>  Homo Sapiens

<400>  7305

Met Val Ala Leu Pro Met Val Leu Val Leu Leu Leu Val Leu Ser Arg 
1               5                   10                  15      


Gly Glu Ser Glu Leu Asp Ala Lys Ile Pro Ser Thr Gly Asp Ala Thr 
            20                  25                  30          


Glu Trp Arg Asn Pro His Leu Ser Met Leu Gly Ser Cys Gln Pro Ala 
        35                  40                  45              


Pro Ser Cys Gln Lys Cys Ile Leu Ser His Pro Ser Cys Ala Trp Cys 
    50                  55                  60                  


Lys Gln Leu Asn Phe Thr Ala Ser Gly Glu Ala Glu Ala Arg Arg Cys 
65                  70                  75                  80  


Ala Arg Arg Glu Glu Leu Leu Ala Arg Gly Cys Pro Leu Glu Glu Leu 
                85                  90                  95      


Glu Glu Pro Arg Gly Gln Gln Glu Val Leu Gln Asp Gln Pro Leu Ser 
            100                 105                 110         


Gln Gly Ala Arg Gly Glu Gly Ala Thr Gln Leu Ala Pro Gln Arg Val 
        115                 120                 125             


Arg Val Thr Leu Arg Pro Gly Glu Pro Gln Gln Leu Gln Val Arg Phe 
    130                 135                 140                 


Leu Arg Ala Glu Gly Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu 
145                 150                 155                 160 


Ser Tyr Ser Met Lys Asp Asp Leu Glu Arg Val Arg Gln Leu Gly His 
                165                 170                 175     


Ala Leu Leu Val Arg Leu Gln Glu Val Thr His Ser Val Arg Ile Gly 
            180                 185                 190         


Phe Gly Ser Phe Val Asp Lys Thr Val Leu Pro Phe Val Ser Thr Val 
        195                 200                 205             


Pro Ser Lys Leu Arg His Pro Cys Pro Thr Arg Leu Glu Arg Cys Gln 
    210                 215                 220                 


Ser Pro Phe Ser Phe His His Val Leu Ser Leu Thr Gly Asp Ala Gln 
225                 230                 235                 240 


Ala Phe Glu Arg Glu Val Gly Arg Gln Ser Val Ser Gly Asn Leu Asp 
                245                 250                 255     


Ser Pro Glu Gly Gly Phe Asp Ala Ile Leu Gln Ala Ala Leu Cys Gln 
            260                 265                 270         


Glu Gln Ile Gly Trp Arg Asn Val Ser Arg Leu Leu Val Phe Thr Ser 
        275                 280                 285             


Asp Asp Thr Phe His Thr Ala Gly Asp Gly Lys Leu Gly Gly Ile Phe 
    290                 295                 300                 


Met Pro Ser Asp Gly His Cys His Leu Asp Ser Asn Gly Leu Tyr Ser 
305                 310                 315                 320 


Arg Ser Thr Glu Phe Asp Tyr Pro Ser Val Gly Gln Val Ala Gln Ala 
                325                 330                 335     


Leu Ser Ala Ala Asn Ile Gln Pro Ile Phe Ala Val Thr Ser Ala Ala 
            340                 345                 350         


Leu Pro Val Tyr Gln Glu Leu Ser Lys Leu Ile Pro Lys Ser Ala Val 
        355                 360                 365             


Gly Glu Leu Ser Glu Asp Ser Ser Asn Val Val Gln Leu Ile Met Asp 
    370                 375                 380                 


Ala Tyr Asn Ser Leu Ser Ser Thr Val Thr Leu Glu His Ser Ser Leu 
385                 390                 395                 400 


Pro Pro Gly Val His Ile Ser Tyr Glu Ser Gln Cys Glu Gly Pro Glu 
                405                 410                 415     


Lys Arg Glu Gly Lys Ala Glu Asp Arg Gly Gln Cys Asn His Val Arg 
            420                 425                 430         


Ile Asn Gln Thr Val Thr Phe Trp Val Ser Leu Gln Ala Thr His Cys 
        435                 440                 445             


Leu Pro Glu Pro His Leu Leu Arg Leu Arg Ala Leu Gly Phe Ser Glu 
    450                 455                 460                 


Glu Leu Ile Val Glu Leu His Thr Leu Cys Asp Cys Asn Cys Ser Asp 
465                 470                 475                 480 


Thr Gln Pro Gln Ala Pro His Cys Ser Asp Gly Gln Gly His Leu Gln 
                485                 490                 495     


Cys Gly Val Cys Ser Cys Ala Pro Gly Arg Leu Gly Arg Leu Cys Glu 
            500                 505                 510         


Cys Ser Val Ala Glu Leu Ser Ser Pro Asp Leu Glu Ser Gly Cys Arg 
        515                 520                 525             


Ala Pro Asn Gly Thr Gly Pro Leu Cys Ser Gly Lys Gly His Cys Gln 
    530                 535                 540                 


Cys Gly Arg Cys Ser Cys Ser Gly Gln Ser Ser Gly His Leu Cys Glu 
545                 550                 555                 560 


Cys Asp Asp Ala Ser Cys Glu Arg His Glu Gly Ile Leu Cys Gly Gly 
                565                 570                 575     


Phe Gly Arg Cys Gln Cys Gly Val Cys His Cys His Ala Asn Arg Thr 
            580                 585                 590         


Gly Arg Ala Cys Glu Cys Ser Gly Asp Met Asp Ser Cys Ile Ser Pro 
        595                 600                 605             


Glu Gly Gly Leu Cys Ser Gly His Gly Arg Cys Lys Cys Asn Arg Cys 
    610                 615                 620                 


Gln Cys Leu Asp Gly Tyr Tyr Gly Ala Leu Cys Asp Gln Cys Pro Gly 
625                 630                 635                 640 


Cys Lys Thr Pro Cys Glu Arg His Arg Asp Cys Ala Glu Cys Gly Ala 
                645                 650                 655     


Phe Arg Thr Gly Pro Leu Ala Thr Asn Cys Ser Thr Ala Cys Ala His 
            660                 665                 670         


Thr Asn Val Thr Leu Ala Leu Ala Pro Ile Leu Asp Asp Gly Trp Cys 
        675                 680                 685             


Lys Glu Arg Thr Leu Asp Asn Gln Leu Phe Phe Phe Leu Val Glu Asp 
    690                 695                 700                 


Asp Ala Arg Gly Thr Val Val Leu Arg Val Arg Pro Gln Glu Lys Gly 
705                 710                 715                 720 


Ala Asp His Thr Gln Ala Ile Val Leu Gly Cys Val Gly Gly Ile Val 
                725                 730                 735     


Ala Val Gly Leu Gly Leu Val Leu Ala Tyr Arg Leu Ser Val Glu Ile 
            740                 745                 750         


Tyr Asp Arg Arg Glu Tyr Ser Arg Phe Glu Lys Glu Gln Gln Gln Leu 
        755                 760                 765             


Asn Trp Lys Gln Asp Ser Asn Pro Leu Tyr Lys Ser Ala Ile Thr Thr 
    770                 775                 780                 


Thr Ile Asn Pro Arg Phe Gln Glu Ala Asp Ser Pro Thr Leu 
785                 790                 795             


<210>  7306
<211>  798
<212>  PRT
<213>  Homo Sapiens

<400>  7306

Met Val Ala Leu Pro Met Val Leu Val Leu Leu Leu Val Leu Ser Arg 
1               5                   10                  15      


Gly Glu Ser Glu Leu Asp Ala Lys Ile Pro Ser Thr Gly Asp Ala Thr 
            20                  25                  30          


Glu Trp Arg Asn Pro His Leu Ser Met Leu Gly Ser Cys Gln Pro Ala 
        35                  40                  45              


Pro Ser Cys Gln Lys Cys Ile Leu Ser His Pro Ser Cys Ala Trp Cys 
    50                  55                  60                  


Lys Gln Leu Asn Phe Thr Ala Ser Gly Glu Ala Glu Ala Arg Arg Cys 
65                  70                  75                  80  


Ala Arg Arg Glu Glu Leu Leu Ala Arg Gly Cys Pro Leu Glu Glu Leu 
                85                  90                  95      


Glu Glu Pro Arg Gly Gln Gln Glu Val Leu Gln Asp Gln Pro Leu Ser 
            100                 105                 110         


Gln Gly Ala Arg Gly Glu Gly Ala Thr Gln Leu Ala Pro Gln Arg Val 
        115                 120                 125             


Arg Val Thr Leu Arg Pro Gly Glu Pro Gln Gln Leu Gln Val Arg Phe 
    130                 135                 140                 


Leu Arg Ala Glu Gly Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu 
145                 150                 155                 160 


Ser Tyr Ser Met Lys Asp Asp Leu Glu Arg Val Arg Gln Leu Gly His 
                165                 170                 175     


Ala Leu Leu Val Arg Leu Gln Glu Val Thr His Ser Val Arg Ile Gly 
            180                 185                 190         


Phe Gly Ser Phe Val Asp Lys Thr Val Leu Pro Phe Val Ser Thr Val 
        195                 200                 205             


Pro Ser Lys Leu Arg His Pro Cys Pro Thr Arg Leu Glu Arg Cys Gln 
    210                 215                 220                 


Ser Pro Phe Ser Phe His His Val Leu Ser Leu Thr Gly Asp Ala Gln 
225                 230                 235                 240 


Ala Phe Glu Arg Glu Val Gly Arg Gln Ser Val Ser Gly Asn Leu Asp 
                245                 250                 255     


Ser Pro Glu Gly Gly Phe Asp Ala Ile Leu Gln Ala Ala Leu Cys Gln 
            260                 265                 270         


Glu Gln Ile Gly Trp Arg Asn Val Ser Arg Leu Leu Val Phe Thr Ser 
        275                 280                 285             


Asp Asp Thr Phe His Thr Ala Gly Asp Gly Lys Leu Gly Gly Ile Phe 
    290                 295                 300                 


Met Pro Ser Asp Gly His Cys His Leu Asp Ser Asn Gly Leu Tyr Ser 
305                 310                 315                 320 


Arg Ser Thr Glu Phe Asp Tyr Pro Ser Val Gly Gln Val Ala Gln Ala 
                325                 330                 335     


Leu Ser Ala Ala Asn Ile Gln Pro Ile Phe Ala Val Thr Ser Ala Ala 
            340                 345                 350         


Leu Pro Val Tyr Gln Glu Leu Ser Lys Leu Ile Pro Lys Ser Ala Val 
        355                 360                 365             


Gly Glu Leu Ser Glu Asp Ser Ser Asn Val Val Gln Leu Ile Met Asp 
    370                 375                 380                 


Ala Tyr Asn Ser Leu Ser Ser Thr Val Thr Leu Glu His Ser Ser Leu 
385                 390                 395                 400 


Pro Pro Gly Val His Ile Ser Tyr Glu Ser Gln Cys Glu Gly Pro Glu 
                405                 410                 415     


Lys Arg Glu Gly Lys Ala Glu Asp Arg Gly Gln Cys Asn His Val Arg 
            420                 425                 430         


Ile Asn Gln Thr Val Thr Phe Trp Val Ser Leu Gln Ala Thr His Cys 
        435                 440                 445             


Leu Pro Glu Pro His Leu Leu Arg Leu Arg Ala Leu Gly Phe Ser Glu 
    450                 455                 460                 


Glu Leu Ile Val Glu Leu His Thr Leu Cys Asp Cys Asn Cys Ser Asp 
465                 470                 475                 480 


Thr Gln Pro Gln Ala Pro His Cys Ser Asp Gly Gln Gly His Leu Gln 
                485                 490                 495     


Cys Gly Val Cys Ser Cys Ala Pro Gly Arg Leu Gly Arg Leu Cys Glu 
            500                 505                 510         


Cys Ser Val Ala Glu Leu Ser Ser Pro Asp Leu Glu Ser Gly Cys Arg 
        515                 520                 525             


Ala Pro Asn Gly Thr Gly Pro Leu Cys Ser Gly Lys Gly His Cys Gln 
    530                 535                 540                 


Cys Gly Arg Cys Ser Cys Ser Gly Gln Ser Ser Gly His Leu Cys Glu 
545                 550                 555                 560 


Cys Asp Asp Ala Ser Cys Glu Arg His Glu Gly Ile Leu Cys Gly Gly 
                565                 570                 575     


Phe Gly Arg Cys Gln Cys Gly Val Cys His Cys His Ala Asn Arg Thr 
            580                 585                 590         


Gly Arg Ala Cys Glu Cys Ser Gly Asp Met Asp Ser Cys Ile Ser Pro 
        595                 600                 605             


Glu Gly Gly Leu Cys Ser Gly His Gly Arg Cys Lys Cys Asn Arg Cys 
    610                 615                 620                 


Gln Cys Leu Asp Gly Tyr Tyr Gly Ala Leu Cys Asp Gln Cys Pro Gly 
625                 630                 635                 640 


Cys Lys Thr Pro Cys Glu Arg His Arg Asp Cys Ala Glu Cys Gly Ala 
                645                 650                 655     


Phe Arg Thr Gly Pro Leu Ala Thr Asn Cys Ser Thr Ala Cys Ala His 
            660                 665                 670         


Thr Asn Val Thr Leu Ala Leu Ala Pro Ile Leu Asp Asp Gly Trp Cys 
        675                 680                 685             


Lys Glu Arg Thr Leu Asp Asn Gln Leu Phe Phe Phe Leu Val Glu Asp 
    690                 695                 700                 


Asp Ala Arg Gly Thr Val Val Leu Arg Val Arg Pro Gln Glu Lys Gly 
705                 710                 715                 720 


Ala Asp His Thr Gln Ala Ile Val Leu Gly Cys Val Gly Gly Ile Val 
                725                 730                 735     


Ala Val Gly Leu Gly Leu Val Leu Ala Tyr Arg Leu Ser Val Glu Ile 
            740                 745                 750         


Tyr Asp Arg Arg Glu Tyr Ser Arg Phe Glu Lys Glu Gln Gln Gln Leu 
        755                 760                 765             


Asn Trp Lys Gln Asp Ser Asn Pro Leu Tyr Lys Ser Ala Ile Thr Thr 
    770                 775                 780                 


Thr Ile Asn Pro Arg Phe Gln Glu Ala Asp Ser Pro Thr Leu 
785                 790                 795             


<210>  7307
<211>  650
<212>  PRT
<213>  Homo Sapiens

<400>  7307

Met Val Ala Leu Pro Met Val Leu Val Leu Leu Leu Val Leu Ser Arg 
1               5                   10                  15      


Gly Glu Ser Glu Leu Asp Ala Lys Ile Pro Ser Thr Gly Asp Ala Thr 
            20                  25                  30          


Glu Trp Arg Asn Pro His Leu Ser Met Leu Gly Ser Cys Gln Pro Ala 
        35                  40                  45              


Pro Ser Cys Gln Lys Cys Ile Leu Ser His Pro Ser Cys Ala Trp Cys 
    50                  55                  60                  


Lys Gln Leu Asn Phe Thr Ala Ser Gly Glu Ala Glu Ala Arg Arg Cys 
65                  70                  75                  80  


Ala Arg Arg Glu Glu Leu Leu Ala Arg Gly Cys Pro Leu Glu Glu Leu 
                85                  90                  95      


Glu Glu Pro Arg Gly Gln Gln Glu Val Leu Gln Asp Gln Pro Leu Ser 
            100                 105                 110         


Gln Gly Ala Arg Gly Glu Gly Ala Thr Gln Leu Ala Pro Gln Arg Val 
        115                 120                 125             


Arg Val Thr Leu Arg Pro Gly Glu Pro Gln Gln Leu Gln Val Arg Phe 
    130                 135                 140                 


Leu Arg Ala Glu Gly Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu 
145                 150                 155                 160 


Ser Tyr Ser Met Lys Asp Asp Leu Glu Arg Val Arg Gln Leu Gly His 
                165                 170                 175     


Ala Leu Leu Val Arg Leu Gln Glu Val Thr His Ser Val Arg Ile Gly 
            180                 185                 190         


Phe Gly Ser Phe Val Asp Lys Thr Val Leu Pro Phe Val Ser Thr Val 
        195                 200                 205             


Pro Ser Lys Leu Arg His Pro Cys Pro Thr Arg Leu Glu Arg Cys Gln 
    210                 215                 220                 


Ser Pro Phe Ser Phe His His Val Leu Ser Leu Thr Gly Asp Ala Gln 
225                 230                 235                 240 


Ala Phe Glu Arg Glu Val Gly Arg Gln Ser Val Ser Gly Asn Leu Asp 
                245                 250                 255     


Ser Pro Glu Gly Gly Phe Asp Ala Ile Leu Gln Ala Ala Leu Cys Gln 
            260                 265                 270         


Glu Gln Ile Gly Trp Arg Asn Val Ser Arg Leu Leu Val Phe Thr Ser 
        275                 280                 285             


Asp Asp Thr Phe His Thr Ala Gly Asp Gly Lys Leu Gly Gly Ile Phe 
    290                 295                 300                 


Met Pro Ser Asp Gly His Cys His Leu Asp Ser Asn Gly Leu Tyr Ser 
305                 310                 315                 320 


Arg Ser Thr Glu Phe Asp Tyr Pro Ser Val Gly Gln Val Ala Gln Ala 
                325                 330                 335     


Leu Ser Ala Ala Asn Ile Gln Pro Ile Phe Ala Val Thr Ser Ala Ala 
            340                 345                 350         


Leu Pro Val Tyr Gln Glu Leu Ser Lys Leu Ile Pro Lys Ser Ala Val 
        355                 360                 365             


Gly Glu Leu Ser Glu Asp Ser Ser Asn Val Val Gln Leu Ile Met Asp 
    370                 375                 380                 


Ala Tyr Asn Ser Leu Ser Ser Thr Val Thr Leu Glu His Ser Ser Leu 
385                 390                 395                 400 


Pro Pro Gly Val His Ile Ser Tyr Glu Ser Gln Cys Glu Gly Pro Glu 
                405                 410                 415     


Lys Arg Glu Gly Lys Ala Glu Asp Arg Gly Gln Cys Asn His Val Arg 
            420                 425                 430         


Ile Asn Gln Thr Val Thr Phe Trp Val Ser Leu Gln Ala Thr His Cys 
        435                 440                 445             


Leu Pro Glu Pro His Leu Leu Arg Leu Arg Ala Leu Gly Phe Ser Glu 
    450                 455                 460                 


Glu Leu Ile Val Glu Leu His Thr Leu Cys Asp Cys Asn Cys Ser Asp 
465                 470                 475                 480 


Thr Gln Pro Gln Ala Pro His Cys Ser Asp Gly Gln Gly His Leu Gln 
                485                 490                 495     


Cys Gly Val Cys Arg Asp Cys Ala Glu Cys Gly Ala Phe Arg Thr Gly 
            500                 505                 510         


Pro Leu Ala Thr Asn Cys Ser Thr Ala Cys Ala His Thr Asn Val Thr 
        515                 520                 525             


Leu Ala Leu Ala Pro Ile Leu Asp Asp Gly Trp Cys Lys Glu Arg Thr 
    530                 535                 540                 


Leu Asp Asn Gln Leu Phe Phe Phe Leu Val Glu Asp Asp Ala Arg Gly 
545                 550                 555                 560 


Thr Val Val Leu Arg Val Arg Pro Gln Glu Lys Gly Ala Asp His Thr 
                565                 570                 575     


Gln Ala Ile Val Leu Gly Cys Val Gly Gly Ile Val Ala Val Gly Leu 
            580                 585                 590         


Gly Leu Val Leu Ala Tyr Arg Leu Ser Val Glu Ile Tyr Asp Arg Arg 
        595                 600                 605             


Glu Tyr Ser Arg Phe Glu Lys Glu Gln Gln Gln Leu Asn Trp Lys Gln 
    610                 615                 620                 


Asp Ser Asn Pro Leu Tyr Lys Ser Ala Ile Thr Thr Thr Ile Asn Pro 
625                 630                 635                 640 


Arg Phe Gln Glu Ala Asp Ser Pro Thr Leu 
                645                 650 


<210>  7308
<211>  471
<212>  PRT
<213>  Homo Sapiens

<400>  7308

Met Val Ala Leu Pro Met Val Leu Val Leu Leu Leu Val Leu Ser Arg 
1               5                   10                  15      


Gly Glu Ser Glu Leu Asp Ala Lys Ile Pro Ser Thr Gly Asp Ala Thr 
            20                  25                  30          


Glu Trp Arg Asn Pro His Leu Ser Met Leu Gly Ser Cys Gln Pro Ala 
        35                  40                  45              


Pro Ser Cys Gln Lys Cys Ile Leu Ser His Pro Ser Cys Ala Trp Cys 
    50                  55                  60                  


Lys Gln Leu Asn Phe Thr Ala Ser Gly Glu Ala Glu Ala Arg Arg Cys 
65                  70                  75                  80  


Ala Arg Arg Glu Glu Leu Leu Ala Arg Gly Cys Pro Leu Glu Glu Leu 
                85                  90                  95      


Glu Glu Pro Arg Gly Gln Gln Glu Val Leu Gln Asp Gln Pro Leu Ser 
            100                 105                 110         


Gln Gly Ala Arg Gly Glu Gly Ala Thr Gln Leu Ala Pro Gln Arg Val 
        115                 120                 125             


Arg Val Thr Leu Arg Pro Gly Glu Pro Gln Gln Leu Gln Val Arg Phe 
    130                 135                 140                 


Leu Arg Ala Glu Gly Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu 
145                 150                 155                 160 


Ser Tyr Ser Met Lys Asp Asp Leu Glu Arg Val Arg Gln Leu Gly His 
                165                 170                 175     


Ala Leu Leu Val Arg Leu Gln Glu Val Thr His Ser Val Arg Ile Gly 
            180                 185                 190         


Phe Gly Ser Phe Val Asp Lys Thr Val Leu Pro Phe Val Ser Thr Val 
        195                 200                 205             


Pro Ser Lys Leu Arg His Pro Cys Pro Thr Arg Leu Glu Arg Cys Gln 
    210                 215                 220                 


Ser Pro Phe Ser Phe His His Val Leu Ser Leu Thr Gly Asp Ala Gln 
225                 230                 235                 240 


Ala Phe Glu Arg Glu Val Gly Arg Gln Ser Val Ser Gly Asn Leu Asp 
                245                 250                 255     


Ser Pro Glu Gly Gly Phe Asp Ala Ile Leu Gln Ala Ala Leu Cys Gln 
            260                 265                 270         


Glu Gln Ile Gly Trp Arg Asn Val Ser Arg Leu Leu Val Phe Thr Ser 
        275                 280                 285             


Asp Asp Thr Phe His Thr Ala Gly Asp Gly Lys Leu Gly Gly Ile Phe 
    290                 295                 300                 


Met Pro Ser Asp Gly His Cys His Leu Asp Ser Asn Gly Leu Tyr Ser 
305                 310                 315                 320 


Arg Ser Thr Glu Phe Asp Tyr Pro Ser Val Gly Gln Val Ala Gln Ala 
                325                 330                 335     


Leu Ser Ala Ala Asn Ile Gln Pro Ile Phe Ala Val Thr Ser Ala Ala 
            340                 345                 350         


Leu Pro Val Tyr Gln Glu Leu Ser Lys Leu Ile Pro Lys Ser Ala Val 
        355                 360                 365             


Gly Glu Leu Ser Glu Asp Ser Ser Asn Val Val Gln Leu Ile Met Asp 
    370                 375                 380                 


Ala Tyr Asn Ser Leu Ser Ser Thr Val Thr Leu Glu His Ser Ser Leu 
385                 390                 395                 400 


Pro Pro Gly Val His Ile Ser Tyr Glu Ser Gln Cys Glu Gly Pro Glu 
                405                 410                 415     


Lys Arg Glu Gly Lys Ala Glu Asp Arg Gly Gln Cys Asn His Val Arg 
            420                 425                 430         


Ile Asn Gln Thr Gly Leu Cys Arg Val Trp Gly Leu Gln Asp Trp Pro 
        435                 440                 445             


Thr Gly His Gln Leu Gln Tyr Ser Leu Cys Pro Tyr Gln Cys Asp Pro 
    450                 455                 460                 


Gly Leu Gly Pro Tyr Leu Gly 
465                 470     


<210>  7309
<211>  117
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7309

Xaa Ser Thr Ala Cys Ala His Thr Asn Val Thr Leu Ala Leu Ala Pro 
1               5                   10                  15      


Ile Leu Asp Asp Gly Trp Cys Lys Glu Arg Thr Leu Asp Asn Gln Leu 
            20                  25                  30          


Phe Phe Phe Leu Val Glu Asp Asp Ala Arg Gly Thr Val Val Leu Arg 
        35                  40                  45              


Val Arg Pro Gln Glu Lys Gly Ala Asp His Thr Gln Ala Ile Val Leu 
    50                  55                  60                  


Gly Cys Val Gly Gly Ile Val Ala Val Gly Leu Gly Leu Val Leu Ala 
65                  70                  75                  80  


Tyr Arg Leu Ser Val Glu Ile Tyr Asp Arg Arg Glu Tyr Ser Arg Phe 
                85                  90                  95      


Glu Lys Glu Gln Gln Gln Leu Asn Trp Lys Gln Leu Leu Gly Phe Gly 
            100                 105                 110         


Ser Arg Leu Ala Ser 
        115         


<210>  7310
<211>  353
<212>  PRT
<213>  Homo Sapiens

<400>  7310

Met Cys Lys Asn Ser Gln Asp Ile Ile Cys Ser Asn Ala Gly Thr Cys 
1               5                   10                  15      


His Cys Gly Arg Cys Lys Cys Asp Asn Ser Asp Gly Ser Gly Leu Val 
            20                  25                  30          


Tyr Gly Lys Phe Cys Glu Cys Asp Asp Arg Glu Cys Ile Asp Asp Glu 
        35                  40                  45              


Thr Glu Glu Ile Cys Gly Gly His Gly Lys Cys Tyr Cys Gly Asn Cys 
    50                  55                  60                  


Tyr Cys Lys Ala Gly Trp His Gly Asp Lys Cys Glu Phe Gln Cys Asp 
65                  70                  75                  80  


Ile Thr Pro Trp Glu Ser Lys Arg Arg Cys Thr Ser Pro Asp Gly Lys 
                85                  90                  95      


Ile Cys Ser Asn Arg Gly Thr Cys Val Cys Gly Glu Cys Thr Cys His 
            100                 105                 110         


Asp Val Asp Pro Thr Gly Asp Trp Gly Asp Ile His Gly Asp Thr Cys 
        115                 120                 125             


Glu Cys Asp Glu Arg Asp Cys Arg Ala Val Tyr Asp Arg Tyr Ser Asp 
    130                 135                 140                 


Asp Phe Cys Ser Gly His Gly Gln Cys Asn Cys Gly Arg Cys Asp Cys 
145                 150                 155                 160 


Lys Ala Gly Trp Tyr Gly Lys Lys Cys Glu His Pro Gln Ser Cys Thr 
                165                 170                 175     


Leu Ser Ala Glu Glu Ser Ile Arg Lys Cys Gln Gly Ser Ser Asp Leu 
            180                 185                 190         


Pro Cys Ser Gly Arg Gly Lys Cys Glu Cys Gly Lys Cys Thr Cys Tyr 
        195                 200                 205             


Pro Pro Gly Asp Arg Arg Val Tyr Gly Lys Thr Cys Glu Cys Asp Asp 
    210                 215                 220                 


Arg Arg Cys Glu Asp Leu Asp Gly Val Val Cys Gly Gly His Gly Thr 
225                 230                 235                 240 


Cys Ser Cys Gly Arg Cys Val Cys Glu Arg Gly Trp Phe Gly Lys Leu 
                245                 250                 255     


Cys Gln His Pro Arg Lys Cys Asn Met Thr Glu Glu Gln Ser Lys Asn 
            260                 265                 270         


Leu Cys Glu Ser Ala Asp Gly Ile Leu Cys Ser Gly Lys Gly Ser Cys 
        275                 280                 285             


His Cys Gly Lys Cys Ile Cys Ser Ala Glu Glu Trp Tyr Ile Ser Gly 
    290                 295                 300                 


Glu Phe Cys Asp Cys Asp Asp Arg Asp Cys Asp Lys His Asp Gly Leu 
305                 310                 315                 320 


Ile Cys Thr Gly Asn Gly Ile Cys Ser Cys Gly Asn Cys Glu Cys Trp 
                325                 330                 335     


Asp Gly Trp Asn Gly Asn Ala Cys Glu Ile Trp Leu Gly Ser Glu Tyr 
            340                 345                 350         


Pro 
    


<210>  7311
<211>  401
<212>  PRT
<213>  Homo Sapiens

<400>  7311

Met Asn Leu Val Ala Val Met Gly Ala Phe Asn Lys Gly His Gly Lys 
1               5                   10                  15      


Cys Asp Cys Gly Lys Cys Lys Cys Asp Gln Gly Trp Tyr Gly Asp Ala 
            20                  25                  30          


Cys Gln Tyr Pro Thr Asn Cys Asp Leu Thr Lys Lys Lys Ser Asn Gln 
        35                  40                  45              


Met Cys Lys Asn Ser Gln Asp Ile Ile Cys Ser Asn Ala Gly Thr Cys 
    50                  55                  60                  


His Cys Gly Arg Cys Lys Cys Asp Asn Ser Asp Gly Ser Gly Leu Val 
65                  70                  75                  80  


Tyr Gly Lys Phe Cys Glu Cys Asp Asp Arg Glu Cys Ile Asp Asp Glu 
                85                  90                  95      


Thr Glu Glu Ile Cys Gly Gly His Gly Lys Cys Tyr Cys Gly Asn Cys 
            100                 105                 110         


Tyr Cys Lys Ala Gly Trp His Gly Asp Lys Cys Glu Phe Gln Cys Asp 
        115                 120                 125             


Ile Thr Pro Trp Glu Ser Lys Arg Arg Cys Thr Ser Pro Asp Gly Lys 
    130                 135                 140                 


Ile Cys Ser Asn Arg Gly Thr Cys Val Cys Gly Glu Cys Thr Cys His 
145                 150                 155                 160 


Asp Val Asp Pro Thr Gly Asp Trp Gly Asp Ile His Gly Asp Thr Cys 
                165                 170                 175     


Glu Cys Asp Glu Arg Asp Cys Arg Ala Val Tyr Asp Arg Tyr Ser Asp 
            180                 185                 190         


Asp Phe Cys Ser Gly His Gly Gln Cys Asn Cys Gly Arg Cys Asp Cys 
        195                 200                 205             


Lys Ala Gly Trp Tyr Gly Lys Lys Cys Glu His Pro Gln Ser Cys Thr 
    210                 215                 220                 


Leu Ser Ala Glu Glu Ser Ile Arg Lys Cys Gln Gly Ser Ser Asp Leu 
225                 230                 235                 240 


Pro Cys Ser Gly Arg Gly Lys Cys Glu Cys Gly Lys Cys Thr Cys Tyr 
                245                 250                 255     


Pro Pro Gly Asp Arg Arg Val Tyr Gly Lys Thr Cys Glu Cys Asp Asp 
            260                 265                 270         


Arg Arg Cys Glu Asp Leu Asp Gly Val Val Cys Gly Gly His Gly Thr 
        275                 280                 285             


Cys Ser Cys Gly Arg Cys Val Cys Glu Arg Gly Trp Phe Gly Lys Leu 
    290                 295                 300                 


Cys Gln His Pro Arg Lys Cys Asn Met Thr Glu Glu Gln Ser Lys Asn 
305                 310                 315                 320 


Leu Cys Glu Ser Ala Asp Gly Ile Leu Cys Ser Gly Lys Gly Ser Cys 
                325                 330                 335     


His Cys Gly Lys Cys Ile Cys Ser Ala Glu Glu Trp Tyr Ile Ser Gly 
            340                 345                 350         


Glu Phe Cys Asp Cys Asp Asp Arg Asp Cys Asp Lys His Asp Gly Leu 
        355                 360                 365             


Ile Cys Thr Gly Asn Gly Ile Cys Ser Cys Gly Asn Cys Glu Cys Trp 
    370                 375                 380                 


Asp Gly Trp Asn Gly Asn Ala Cys Glu Ile Trp Leu Gly Ser Glu Tyr 
385                 390                 395                 400 


Pro 
    


<210>  7312
<211>  494
<212>  PRT
<213>  Homo Sapiens

<400>  7312

Met Arg Pro Pro Gly Phe Arg Asn Phe Leu Leu Leu Ala Ser Ser Leu 
1               5                   10                  15      


Leu Phe Ala Gly Leu Ser Ala Val Pro Gln Ser Phe Ser Pro Ser Leu 
            20                  25                  30          


Arg Ser Trp Pro Gly Ala Ala Cys Arg Leu Ser Arg Ala Glu Ser Glu 
        35                  40                  45              


Arg Arg Cys Arg Ala Pro Gly Gln Pro Pro Gly Ala Ala Leu Cys His 
    50                  55                  60                  


Gly Arg Gly Arg Cys Asp Cys Gly Val Cys Ile Cys His Val Thr Glu 
65                  70                  75                  80  


Pro Gly Met Phe Phe Gly Pro Leu Cys Glu Cys His Glu Trp Val Cys 
                85                  90                  95      


Glu Thr Tyr Asp Gly Ser Thr Cys Ala Gly His Gly Lys Cys Asp Cys 
            100                 105                 110         


Gly Lys Cys Lys Cys Asp Gln Gly Trp Tyr Gly Asp Ala Cys Gln Tyr 
        115                 120                 125             


Pro Thr Asn Cys Asp Leu Thr Lys Lys Lys Ser Asn Gln Met Cys Lys 
    130                 135                 140                 


Asn Ser Gln Asp Ile Ile Cys Ser Asn Ala Gly Thr Cys His Cys Gly 
145                 150                 155                 160 


Arg Cys Lys Cys Asp Asn Ser Asp Gly Ser Gly Leu Val Tyr Gly Lys 
                165                 170                 175     


Phe Cys Glu Cys Asp Asp Arg Glu Cys Ile Asp Asp Glu Thr Glu Glu 
            180                 185                 190         


Ile Cys Gly Gly His Gly Lys Cys Tyr Cys Gly Asn Cys Tyr Cys Lys 
        195                 200                 205             


Ala Gly Trp His Gly Asp Lys Cys Glu Phe Gln Cys Asp Ile Thr Pro 
    210                 215                 220                 


Trp Glu Ser Lys Arg Arg Cys Thr Ser Pro Asp Gly Lys Ile Cys Ser 
225                 230                 235                 240 


Asn Arg Gly Thr Cys Val Cys Gly Glu Cys Thr Cys His Asp Val Asp 
                245                 250                 255     


Pro Thr Gly Asp Trp Gly Asp Ile His Gly Asp Thr Cys Glu Cys Asp 
            260                 265                 270         


Glu Arg Asp Cys Arg Ala Val Tyr Asp Arg Tyr Ser Asp Asp Phe Cys 
        275                 280                 285             


Ser Gly His Gly Gln Cys Asn Cys Gly Arg Cys Asp Cys Lys Ala Gly 
    290                 295                 300                 


Trp Tyr Gly Lys Lys Cys Glu His Pro Gln Ser Cys Thr Leu Ser Ala 
305                 310                 315                 320 


Glu Glu Ser Ile Arg Lys Cys Gln Gly Ser Ser Asp Leu Pro Cys Ser 
                325                 330                 335     


Gly Arg Gly Lys Cys Glu Cys Gly Lys Cys Thr Cys Tyr Pro Pro Gly 
            340                 345                 350         


Asp Arg Arg Val Tyr Gly Lys Thr Cys Glu Cys Asp Asp Arg Arg Cys 
        355                 360                 365             


Glu Asp Leu Asp Gly Val Val Cys Gly Gly His Gly Thr Cys Ser Cys 
    370                 375                 380                 


Gly Arg Cys Val Cys Glu Arg Gly Trp Phe Gly Lys Leu Cys Gln His 
385                 390                 395                 400 


Pro Arg Lys Cys Asn Met Thr Glu Glu Gln Ser Lys Asn Leu Cys Glu 
                405                 410                 415     


Ser Ala Asp Gly Ile Leu Cys Ser Gly Lys Gly Ser Cys His Cys Gly 
            420                 425                 430         


Lys Cys Ile Cys Ser Ala Glu Glu Trp Tyr Ile Ser Gly Glu Phe Cys 
        435                 440                 445             


Asp Cys Asp Asp Arg Asp Cys Asp Lys His Asp Gly Leu Ile Cys Thr 
    450                 455                 460                 


Gly Asn Gly Ile Cys Ser Cys Gly Asn Cys Glu Cys Trp Asp Gly Trp 
465                 470                 475                 480 


Asn Gly Asn Ala Cys Glu Ile Trp Leu Gly Ser Glu Tyr Pro 
                485                 490                 


<210>  7313
<211>  445
<212>  PRT
<213>  Homo Sapiens

<400>  7313

Met Arg Pro Pro Gly Phe Arg Asn Phe Leu Leu Leu Ala Ser Ser Leu 
1               5                   10                  15      


Leu Phe Ala Gly Leu Ser Ala Val Pro Gln Ser Phe Ser Pro Ser Leu 
            20                  25                  30          


Arg Ser Trp Pro Gly Ala Ala Cys Arg Leu Ser Arg Ala Glu Ser Glu 
        35                  40                  45              


Arg Arg Cys Arg Ala Pro Gly Gln Pro Pro Gly Ala Ala Leu Cys His 
    50                  55                  60                  


Gly Arg Gly Arg Cys Asp Cys Gly Val Cys Ile Cys His Val Thr Glu 
65                  70                  75                  80  


Pro Gly Met Phe Phe Gly Pro Leu Cys Glu Cys His Glu Trp Val Cys 
                85                  90                  95      


Glu Thr Tyr Asp Gly Ser Thr Cys Ala Gly Thr Cys His Cys Gly Arg 
            100                 105                 110         


Cys Lys Cys Asp Asn Ser Asp Gly Ser Gly Leu Val Tyr Gly Lys Phe 
        115                 120                 125             


Cys Glu Cys Asp Asp Arg Glu Cys Ile Asp Asp Glu Thr Glu Glu Ile 
    130                 135                 140                 


Cys Gly Gly His Gly Lys Cys Tyr Cys Gly Asn Cys Tyr Cys Lys Ala 
145                 150                 155                 160 


Gly Trp His Gly Asp Lys Cys Glu Phe Gln Cys Asp Ile Thr Pro Trp 
                165                 170                 175     


Glu Ser Lys Arg Arg Cys Thr Ser Pro Asp Gly Lys Ile Cys Ser Asn 
            180                 185                 190         


Arg Gly Thr Cys Val Cys Gly Glu Cys Thr Cys His Asp Val Asp Pro 
        195                 200                 205             


Thr Gly Asp Trp Gly Asp Ile His Gly Asp Thr Cys Glu Cys Asp Glu 
    210                 215                 220                 


Arg Asp Cys Arg Ala Val Tyr Asp Arg Tyr Ser Asp Asp Phe Cys Ser 
225                 230                 235                 240 


Gly His Gly Gln Cys Asn Cys Gly Arg Cys Asp Cys Lys Ala Gly Trp 
                245                 250                 255     


Tyr Gly Lys Lys Cys Glu His Pro Gln Ser Cys Thr Leu Ser Ala Glu 
            260                 265                 270         


Glu Ser Ile Arg Lys Cys Gln Gly Ser Ser Asp Leu Pro Cys Ser Gly 
        275                 280                 285             


Arg Gly Lys Cys Glu Cys Gly Lys Cys Thr Cys Tyr Pro Pro Gly Asp 
    290                 295                 300                 


Arg Arg Val Tyr Gly Lys Thr Cys Glu Cys Asp Asp Arg Arg Cys Glu 
305                 310                 315                 320 


Asp Leu Asp Gly Val Val Cys Gly Gly His Gly Thr Cys Ser Cys Gly 
                325                 330                 335     


Arg Cys Val Cys Glu Arg Gly Trp Phe Gly Lys Leu Cys Gln His Pro 
            340                 345                 350         


Arg Lys Cys Asn Met Thr Glu Glu Gln Ser Lys Asn Leu Cys Glu Ser 
        355                 360                 365             


Ala Asp Gly Ile Leu Cys Ser Gly Lys Gly Ser Cys His Cys Gly Lys 
    370                 375                 380                 


Cys Ile Cys Ser Ala Glu Glu Trp Tyr Ile Ser Gly Glu Phe Cys Asp 
385                 390                 395                 400 


Cys Asp Asp Arg Asp Cys Asp Lys His Asp Gly Leu Ile Cys Thr Gly 
                405                 410                 415     


Asn Gly Ile Cys Ser Cys Gly Asn Cys Glu Cys Trp Asp Gly Trp Asn 
            420                 425                 430         


Gly Asn Ala Cys Glu Ile Trp Leu Gly Ser Glu Tyr Pro 
        435                 440                 445 


<210>  7314
<211>  401
<212>  PRT
<213>  Homo Sapiens

<400>  7314

Met Ser Gly Cys Ala Arg Pro Thr Thr Gly Ala Pro Val Gln Ala Met 
1               5                   10                  15      


Val Ser Val Gly Lys Cys Lys Cys Asp Gln Gly Trp Tyr Gly Asp Ala 
            20                  25                  30          


Cys Gln Tyr Pro Thr Asn Cys Asp Leu Thr Lys Lys Lys Ser Asn Gln 
        35                  40                  45              


Met Cys Lys Asn Ser Gln Asp Ile Ile Cys Ser Asn Ala Gly Thr Cys 
    50                  55                  60                  


His Cys Gly Arg Cys Lys Cys Asp Asn Ser Asp Gly Ser Gly Leu Val 
65                  70                  75                  80  


Tyr Gly Lys Phe Cys Glu Cys Asp Asp Arg Glu Cys Ile Asp Asp Glu 
                85                  90                  95      


Thr Glu Glu Ile Cys Gly Gly His Gly Lys Cys Tyr Cys Gly Asn Cys 
            100                 105                 110         


Tyr Cys Lys Ala Gly Trp His Gly Asp Lys Cys Glu Phe Gln Cys Asp 
        115                 120                 125             


Ile Thr Pro Trp Glu Ser Lys Arg Arg Cys Thr Ser Pro Asp Gly Lys 
    130                 135                 140                 


Ile Cys Ser Asn Arg Gly Thr Cys Val Cys Gly Glu Cys Thr Cys His 
145                 150                 155                 160 


Asp Val Asp Pro Thr Gly Asp Trp Gly Asp Ile His Gly Asp Thr Cys 
                165                 170                 175     


Glu Cys Asp Glu Arg Asp Cys Arg Ala Val Tyr Asp Arg Tyr Ser Asp 
            180                 185                 190         


Asp Phe Cys Ser Gly His Gly Gln Cys Asn Cys Gly Arg Cys Asp Cys 
        195                 200                 205             


Lys Ala Gly Trp Tyr Gly Lys Lys Cys Glu His Pro Gln Ser Cys Thr 
    210                 215                 220                 


Leu Ser Ala Glu Glu Ser Ile Arg Lys Cys Gln Gly Ser Ser Asp Leu 
225                 230                 235                 240 


Pro Cys Ser Gly Arg Gly Lys Cys Glu Cys Gly Lys Cys Thr Cys Tyr 
                245                 250                 255     


Pro Pro Gly Asp Arg Arg Val Tyr Gly Lys Thr Cys Glu Cys Asp Asp 
            260                 265                 270         


Arg Arg Cys Glu Asp Leu Asp Gly Val Val Cys Gly Gly His Gly Thr 
        275                 280                 285             


Cys Ser Cys Gly Arg Cys Val Cys Glu Arg Gly Trp Phe Gly Lys Leu 
    290                 295                 300                 


Cys Gln His Pro Arg Lys Cys Asn Met Thr Glu Glu Gln Ser Lys Asn 
305                 310                 315                 320 


Leu Cys Glu Ser Ala Asp Gly Ile Leu Cys Ser Gly Lys Gly Ser Cys 
                325                 330                 335     


His Cys Gly Lys Cys Ile Cys Ser Ala Glu Glu Trp Tyr Ile Ser Gly 
            340                 345                 350         


Glu Phe Cys Asp Cys Asp Asp Arg Asp Cys Asp Lys His Asp Gly Leu 
        355                 360                 365             


Ile Cys Thr Gly Asn Gly Ile Cys Ser Cys Gly Asn Cys Glu Cys Trp 
    370                 375                 380                 


Asp Gly Trp Asn Gly Asn Ala Cys Glu Ile Trp Leu Gly Ser Glu Tyr 
385                 390                 395                 400 


Pro 
    


<210>  7315
<211>  208
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7315

Xaa Cys Glu Gly His Gly Gln Cys Asn Cys Gly Arg Cys Asp Cys Lys 
1               5                   10                  15      


Ala Gly Trp Tyr Gly Lys Lys Cys Glu His Pro Gln Ser Cys Thr Leu 
            20                  25                  30          


Ser Ala Glu Glu Ser Ile Arg Lys Cys Gln Gly Ser Ser Asp Leu Pro 
        35                  40                  45              


Cys Ser Gly Arg Gly Lys Cys Glu Cys Gly Lys Cys Thr Cys Tyr Pro 
    50                  55                  60                  


Pro Gly Asp Arg Arg Val Tyr Gly Lys Thr Cys Glu Cys Asp Asp Arg 
65                  70                  75                  80  


Arg Cys Glu Asp Leu Asp Gly Val Val Cys Gly Gly His Gly Thr Cys 
                85                  90                  95      


Ser Cys Gly Arg Cys Val Cys Glu Arg Gly Trp Phe Gly Lys Leu Cys 
            100                 105                 110         


Gln His Pro Arg Lys Cys Asn Met Thr Glu Glu Gln Ser Lys Asn Leu 
        115                 120                 125             


Cys Glu Ser Ala Asp Gly Ile Leu Cys Ser Gly Lys Gly Ser Cys His 
    130                 135                 140                 


Cys Gly Lys Cys Ile Cys Ser Ala Glu Glu Trp Tyr Ile Ser Gly Glu 
145                 150                 155                 160 


Phe Cys Asp Cys Asp Asp Arg Asp Cys Asp Lys His Asp Gly Leu Ile 
                165                 170                 175     


Cys Thr Gly Asn Gly Ile Cys Ser Cys Gly Asn Cys Glu Cys Trp Asp 
            180                 185                 190         


Gly Trp Asn Gly Asn Ala Cys Glu Ile Trp Leu Gly Ser Glu Tyr Pro 
        195                 200                 205             


<210>  7316
<211>  911
<212>  PRT
<213>  Homo Sapiens

<400>  7316

Met Asp Gly Ala Met Gly Pro Arg Gly Leu Leu Leu Cys Met Tyr Leu 
1               5                   10                  15      


Val Ser Leu Leu Ile Leu Gln Ala Met Pro Ala Leu Gly Ser Ala Thr 
            20                  25                  30          


Gly Arg Ser Lys Ser Ser Glu Lys Arg Gln Ala Val Asp Thr Ala Val 
        35                  40                  45              


Asp Gly Val Phe Ile Arg Ser Leu Lys Val Asn Cys Lys Val Thr Ser 
    50                  55                  60                  


Arg Phe Ala His Tyr Val Val Thr Ser Gln Val Val Asn Thr Ala Asn 
65                  70                  75                  80  


Glu Ala Arg Glu Val Ala Phe Asp Leu Glu Ile Pro Lys Thr Ala Phe 
                85                  90                  95      


Ile Ser Asp Phe Ala Val Thr Ala Asp Gly Asn Ala Phe Ile Gly Asp 
            100                 105                 110         


Ile Lys Asp Lys Val Thr Ala Trp Lys Gln Tyr Arg Lys Ala Ala Ile 
        115                 120                 125             


Ser Gly Glu Asn Ala Gly Leu Val Arg Ala Ser Gly Arg Thr Met Glu 
    130                 135                 140                 


Gln Phe Thr Ile His Leu Thr Val Asn Pro Gln Ser Lys Val Thr Phe 
145                 150                 155                 160 


Gln Leu Thr Tyr Glu Glu Val Leu Lys Arg Asn His Met Gln Tyr Glu 
                165                 170                 175     


Ile Val Ile Lys Val Lys Pro Lys Gln Leu Val His His Phe Glu Ile 
            180                 185                 190         


Asp Val Asp Ile Phe Glu Pro Gln Gly Ile Ser Lys Leu Asp Ala Gln 
        195                 200                 205             


Ala Ser Phe Leu Pro Lys Glu Leu Ala Ala Gln Thr Ile Lys Lys Ser 
    210                 215                 220                 


Phe Ser Gly Lys Lys Gly His Val Leu Phe Arg Pro Thr Val Ser Gln 
225                 230                 235                 240 


Gln Gln Ser Cys Pro Thr Cys Ser Thr Ser Leu Leu Asn Gly His Phe 
                245                 250                 255     


Lys Val Thr Tyr Asp Val Ser Arg Asp Lys Ile Cys Asp Leu Leu Val 
            260                 265                 270         


Ala Asn Asn His Phe Ala His Phe Phe Ala Pro Gln Asn Leu Thr Asn 
        275                 280                 285             


Met Asn Lys Asn Val Val Phe Val Ile Asp Ile Ser Gly Ser Met Arg 
    290                 295                 300                 


Gly Gln Lys Val Lys Gln Thr Lys Glu Ala Leu Leu Lys Ile Leu Gly 
305                 310                 315                 320 


Asp Met Gln Pro Gly Asp Tyr Phe Asp Leu Val Leu Phe Gly Thr Arg 
                325                 330                 335     


Val Gln Ser Trp Lys Gly Ser Leu Val Gln Ala Ser Glu Ala Asn Leu 
            340                 345                 350         


Gln Ala Ala Gln Asp Phe Val Arg Gly Phe Ser Leu Asp Glu Ala Thr 
        355                 360                 365             


Asn Leu Asn Gly Gly Leu Leu Arg Gly Ile Glu Ile Leu Asn Gln Val 
    370                 375                 380                 


Gln Glu Ser Leu Pro Glu Leu Ser Asn His Ala Ser Ile Leu Ile Met 
385                 390                 395                 400 


Leu Thr Asp Gly Asp Pro Thr Glu Gly Val Thr Asp Arg Ser Gln Ile 
                405                 410                 415     


Leu Lys Asn Val Arg Asn Ala Ile Arg Gly Arg Phe Pro Leu Tyr Asn 
            420                 425                 430         


Leu Gly Phe Gly His Asn Val Asp Phe Asn Phe Leu Glu Val Met Ser 
        435                 440                 445             


Met Glu Asn Asn Gly Arg Ala Gln Arg Ile Tyr Glu Asp His Asp Ala 
    450                 455                 460                 


Thr Gln Gln Leu Gln Gly Phe Tyr Ser Gln Val Ala Lys Pro Leu Leu 
465                 470                 475                 480 


Val Asp Val Asp Leu Gln Tyr Pro Gln Asp Ala Val Leu Ala Leu Thr 
                485                 490                 495     


Gln Asn His His Lys Gln Tyr Tyr Glu Gly Ser Glu Ile Val Val Ala 
            500                 505                 510         


Gly Arg Ile Ala Asp Asn Lys Gln Ser Ser Phe Lys Ala Asp Val Gln 
        515                 520                 525             


Ala His Gly Glu Gly Gln Glu Phe Ser Ile Thr Cys Leu Val Asp Glu 
    530                 535                 540                 


Glu Glu Met Lys Lys Leu Leu Arg Glu Arg Gly His Met Leu Glu Asn 
545                 550                 555                 560 


His Val Glu Arg Leu Trp Ala Tyr Leu Thr Ile Gln Glu Leu Leu Ala 
                565                 570                 575     


Lys Arg Met Lys Val Asp Arg Glu Glu Arg Ala Asn Leu Ser Ser Gln 
            580                 585                 590         


Ala Leu Gln Met Ser Leu Asp Tyr Gly Phe Val Thr Pro Leu Thr Ser 
        595                 600                 605             


Met Ser Ile Arg Gly Met Ala Asp Gln Asp Gly Leu Lys Pro Thr Ile 
    610                 615                 620                 


Asp Lys Pro Ser Glu Asp Ser Pro Pro Leu Glu Met Leu Gly Pro Arg 
625                 630                 635                 640 


Arg Thr Phe Val Leu Ser Ala Leu Gln Pro Ser Pro Thr His Ser Ser 
                645                 650                 655     


Ser Asn Thr Gln Arg Leu Pro Asp Arg Val Thr Gly Val Asp Thr Asp 
            660                 665                 670         


Pro His Phe Ile Ile His Val Pro Gln Lys Glu Asp Thr Leu Cys Phe 
        675                 680                 685             


Asn Ile Asn Glu Glu Pro Gly Val Ile Leu Ser Leu Val Gln Asp Pro 
    690                 695                 700                 


Asn Thr Gly Phe Ser Val Asn Gly Gln Leu Ile Gly Asn Lys Ala Arg 
705                 710                 715                 720 


Ser Pro Gly Gln His Asp Gly Thr Tyr Phe Gly Arg Leu Gly Ile Ala 
                725                 730                 735     


Asn Pro Ala Thr Asp Phe Gln Leu Glu Val Thr Pro Gln Asn Ile Thr 
            740                 745                 750         


Leu Asn Pro Gly Phe Gly Gly Pro Val Phe Ser Trp Arg Asp Gln Ala 
        755                 760                 765             


Val Leu Arg Gln Asp Gly Val Val Val Thr Ile Asn Lys Lys Arg Asn 
    770                 775                 780                 


Leu Val Val Ser Val Asp Asp Gly Gly Thr Phe Glu Val Val Leu His 
785                 790                 795                 800 


Arg Val Trp Lys Gly Ser Ser Val His Gln Asp Phe Leu Gly Phe Tyr 
                805                 810                 815     


Val Leu Asp Ser His Arg Met Ser Ala Arg Thr His Gly Leu Leu Gly 
            820                 825                 830         


Gln Phe Phe His Pro Ile Gly Phe Glu Val Ser Asp Ile His Pro Gly 
        835                 840                 845             


Ser Asp Pro Thr Lys Pro Asp Ala Thr Met Val Val Arg Asn Arg Arg 
    850                 855                 860                 


Leu Thr Val Thr Arg Gly Leu Gln Lys Asp Tyr Ser Lys Asp Pro Trp 
865                 870                 875                 880 


His Gly Ala Glu Val Ser Cys Trp Phe Ile His Asn Asn Gly Ala Gly 
                885                 890                 895     


Leu Ile Asp Gly Ala Tyr Thr Asp Tyr Ile Val Pro Asp Ile Phe 
            900                 905                 910     


<210>  7317
<211>  213
<212>  PRT
<213>  Homo Sapiens

<400>  7317

Met Asp Gly Ala Met Gly Pro Arg Gly Leu Leu Leu Cys Met Tyr Leu 
1               5                   10                  15      


Val Ser Leu Leu Ile Leu Gln Ala Met Pro Ala Leu Gly Ser Ala Thr 
            20                  25                  30          


Gly Arg Ser Lys Ser Ser Glu Lys Arg Gln Ala Val Asp Thr Ala Val 
        35                  40                  45              


Asp Gly Val Phe Ile Arg Ser Leu Lys Val Asn Cys Lys Val Thr Ser 
    50                  55                  60                  


Arg Phe Ala His Tyr Val Val Thr Ser Gln Val Val Asn Thr Ala Asn 
65                  70                  75                  80  


Glu Ala Arg Glu Val Ala Phe Asp Leu Glu Ile Pro Lys Thr Ala Phe 
                85                  90                  95      


Ile Ser Asp Phe Ala Val Thr Ala Asp Gly Asn Ala Phe Ile Gly Asp 
            100                 105                 110         


Ile Lys Asp Lys Val Thr Ala Trp Lys Gln Tyr Arg Lys Ala Ala Ile 
        115                 120                 125             


Ser Gly Glu Asn Ala Gly Leu Val Arg Ala Ser Gly Arg Thr Met Glu 
    130                 135                 140                 


Gln Phe Thr Ile His Leu Thr Val Asn Pro Gln Ser Lys Val Thr Phe 
145                 150                 155                 160 


Gln Leu Thr Tyr Glu Glu Val Leu Lys Arg Asn His Met Gln Tyr Glu 
                165                 170                 175     


Ile Val Ile Lys Val Lys Pro Lys Gln Leu Val His His Phe Glu Val 
            180                 185                 190         


Asp His Arg Ser Arg Gly Arg Gly Pro Ala Pro Leu Ser Val Thr Met 
        195                 200                 205             


Ala Pro Asn Thr Gly 
    210             


<210>  7318
<211>  623
<212>  PRT
<213>  Homo Sapiens

<400>  7318

Met Asn Lys Asn Val Val Phe Val Ile Asp Ile Ser Gly Ser Met Arg 
1               5                   10                  15      


Gly Gln Lys Val Lys Gln Thr Lys Glu Ala Leu Leu Lys Ile Leu Gly 
            20                  25                  30          


Asp Met Gln Pro Gly Asp Tyr Phe Asp Leu Val Leu Phe Gly Thr Arg 
        35                  40                  45              


Val Gln Ser Trp Lys Gly Ser Leu Val Gln Ala Ser Glu Ala Asn Leu 
    50                  55                  60                  


Gln Ala Ala Gln Asp Phe Val Arg Gly Phe Ser Leu Asp Glu Ala Thr 
65                  70                  75                  80  


Asn Leu Asn Gly Gly Leu Leu Arg Gly Ile Glu Ile Leu Asn Gln Val 
                85                  90                  95      


Gln Glu Ser Leu Pro Glu Leu Ser Asn His Ala Ser Ile Leu Ile Met 
            100                 105                 110         


Leu Thr Asp Gly Asp Pro Thr Glu Gly Val Thr Asp Arg Ser Gln Ile 
        115                 120                 125             


Leu Lys Asn Val Arg Asn Ala Ile Arg Gly Arg Phe Pro Leu Tyr Asn 
    130                 135                 140                 


Leu Gly Phe Gly His Asn Val Asp Phe Asn Phe Leu Glu Val Met Ser 
145                 150                 155                 160 


Met Glu Asn Asn Gly Arg Ala Gln Arg Ile Tyr Glu Asp His Asp Ala 
                165                 170                 175     


Thr Gln Gln Leu Gln Gly Phe Tyr Ser Gln Val Ala Lys Pro Leu Leu 
            180                 185                 190         


Val Asp Val Asp Leu Gln Tyr Pro Gln Asp Ala Val Leu Ala Leu Thr 
        195                 200                 205             


Gln Asn His His Lys Gln Tyr Tyr Glu Gly Ser Glu Ile Val Val Ala 
    210                 215                 220                 


Gly Arg Ile Ala Asp Asn Lys Gln Ser Ser Phe Lys Ala Asp Val Gln 
225                 230                 235                 240 


Ala His Gly Glu Gly Gln Glu Phe Ser Ile Thr Cys Leu Val Asp Glu 
                245                 250                 255     


Glu Glu Met Lys Lys Leu Leu Arg Glu Arg Gly His Met Leu Glu Asn 
            260                 265                 270         


His Val Glu Arg Leu Trp Ala Tyr Leu Thr Ile Gln Glu Leu Leu Ala 
        275                 280                 285             


Lys Arg Met Lys Val Asp Arg Glu Glu Arg Ala Asn Leu Ser Ser Gln 
    290                 295                 300                 


Ala Leu Gln Met Ser Leu Asp Tyr Gly Phe Val Thr Pro Leu Thr Ser 
305                 310                 315                 320 


Met Ser Ile Arg Gly Met Ala Asp Gln Asp Gly Leu Lys Pro Thr Ile 
                325                 330                 335     


Asp Lys Pro Ser Glu Asp Ser Pro Pro Leu Glu Met Leu Gly Pro Arg 
            340                 345                 350         


Arg Thr Phe Val Leu Ser Ala Leu Gln Pro Ser Pro Thr His Ser Ser 
        355                 360                 365             


Ser Asn Thr Gln Arg Leu Pro Asp Arg Val Thr Gly Val Asp Thr Asp 
    370                 375                 380                 


Pro His Phe Ile Ile His Val Pro Gln Lys Glu Asp Thr Leu Cys Phe 
385                 390                 395                 400 


Asn Ile Asn Glu Glu Pro Gly Val Ile Leu Ser Leu Val Gln Asp Pro 
                405                 410                 415     


Asn Thr Gly Phe Ser Val Asn Gly Gln Leu Ile Gly Asn Lys Ala Arg 
            420                 425                 430         


Ser Pro Gly Gln His Asp Gly Thr Tyr Phe Gly Arg Leu Gly Ile Ala 
        435                 440                 445             


Asn Pro Ala Thr Asp Phe Gln Leu Glu Val Thr Pro Gln Asn Ile Thr 
    450                 455                 460                 


Leu Asn Pro Gly Phe Gly Gly Pro Val Phe Ser Trp Arg Asp Gln Ala 
465                 470                 475                 480 


Val Leu Arg Gln Asp Gly Val Val Val Thr Ile Asn Lys Lys Arg Asn 
                485                 490                 495     


Leu Val Val Ser Val Asp Asp Gly Gly Thr Phe Glu Val Val Leu His 
            500                 505                 510         


Arg Val Trp Lys Gly Ser Ser Val His Gln Asp Phe Leu Gly Phe Tyr 
        515                 520                 525             


Val Leu Asp Ser His Arg Met Ser Ala Arg Thr His Gly Leu Leu Gly 
    530                 535                 540                 


Gln Phe Phe His Pro Ile Gly Phe Glu Val Ser Asp Ile His Pro Gly 
545                 550                 555                 560 


Ser Asp Pro Thr Lys Pro Asp Ala Thr Met Val Val Arg Asn Arg Arg 
                565                 570                 575     


Leu Thr Val Thr Arg Gly Leu Gln Lys Asp Tyr Ser Lys Asp Pro Trp 
            580                 585                 590         


His Gly Ala Glu Val Ser Cys Trp Phe Ile His Asn Asn Gly Ala Gly 
        595                 600                 605             


Leu Ile Asp Gly Ala Tyr Thr Asp Tyr Ile Val Pro Asp Ile Phe 
    610                 615                 620             


<210>  7319
<211>  277
<212>  PRT
<213>  Homo Sapiens

<400>  7319

Met Pro Leu Pro Leu Pro Ser Ala Phe Val Leu Ser Ala Leu Gln Pro 
1               5                   10                  15      


Ser Pro Thr His Ser Ser Ser Asn Thr Gln Arg Leu Pro Asp Arg Val 
            20                  25                  30          


Thr Gly Val Asp Thr Asp Pro His Phe Ile Ile His Val Pro Gln Lys 
        35                  40                  45              


Glu Asp Thr Leu Cys Phe Asn Ile Asn Glu Glu Pro Gly Val Ile Leu 
    50                  55                  60                  


Ser Leu Val Gln Asp Pro Asn Thr Gly Phe Ser Val Asn Gly Gln Leu 
65                  70                  75                  80  


Ile Gly Asn Lys Ala Arg Ser Pro Gly Gln His Asp Gly Thr Tyr Phe 
                85                  90                  95      


Gly Arg Leu Gly Ile Ala Asn Pro Ala Thr Asp Phe Gln Leu Glu Val 
            100                 105                 110         


Thr Pro Gln Asn Ile Thr Leu Asn Pro Gly Phe Gly Gly Pro Val Phe 
        115                 120                 125             


Ser Trp Arg Asp Gln Ala Val Leu Arg Gln Asp Gly Val Val Val Thr 
    130                 135                 140                 


Ile Asn Lys Lys Arg Asn Leu Val Val Ser Val Asp Asp Gly Gly Thr 
145                 150                 155                 160 


Phe Glu Val Val Leu His Arg Val Trp Lys Gly Ser Ser Val His Gln 
                165                 170                 175     


Asp Phe Leu Gly Phe Tyr Val Leu Asp Ser His Arg Met Ser Ala Arg 
            180                 185                 190         


Thr His Gly Leu Leu Gly Gln Phe Phe His Pro Ile Gly Phe Glu Val 
        195                 200                 205             


Ser Asp Ile His Pro Gly Ser Asp Pro Thr Lys Pro Asp Ala Thr Met 
    210                 215                 220                 


Val Val Arg Asn Arg Arg Leu Thr Val Thr Arg Gly Leu Gln Lys Asp 
225                 230                 235                 240 


Tyr Ser Lys Asp Pro Trp His Gly Ala Glu Val Ser Cys Trp Phe Ile 
                245                 250                 255     


His Asn Asn Gly Ala Gly Leu Ile Asp Gly Ala Tyr Thr Asp Tyr Ile 
            260                 265                 270         


Val Pro Asp Ile Phe 
        275         


<210>  7320
<211>  464
<212>  PRT
<213>  Homo Sapiens

<400>  7320

Ser Met Glu Asn Asn Gly Arg Ala Gln Arg Ile Tyr Glu Asp His Asp 
1               5                   10                  15      


Ala Thr Gln Gln Leu Gln Gly Phe Tyr Ser Gln Val Ala Lys Pro Leu 
            20                  25                  30          


Leu Val Asp Val Asp Leu Gln Tyr Pro Gln Asp Ala Val Leu Ala Leu 
        35                  40                  45              


Thr Gln Asn His His Lys Gln Tyr Tyr Glu Gly Ser Glu Ile Val Val 
    50                  55                  60                  


Ala Gly Arg Ile Ala Asp Asn Lys Gln Ser Ser Phe Lys Ala Asp Val 
65                  70                  75                  80  


Gln Ala His Gly Glu Gly Gln Glu Phe Ser Ile Thr Cys Leu Val Asp 
                85                  90                  95      


Glu Glu Glu Met Lys Lys Leu Leu Arg Glu Arg Gly His Met Leu Glu 
            100                 105                 110         


Asn His Val Glu Arg Leu Trp Ala Tyr Leu Thr Ile Gln Glu Leu Leu 
        115                 120                 125             


Ala Lys Arg Met Lys Val Asp Arg Glu Glu Arg Ala Asn Leu Ser Ser 
    130                 135                 140                 


Gln Ala Leu Gln Met Ser Leu Asp Tyr Gly Phe Val Thr Pro Leu Thr 
145                 150                 155                 160 


Ser Met Ser Ile Arg Gly Met Ala Asp Gln Asp Gly Leu Lys Pro Thr 
                165                 170                 175     


Ile Asp Lys Pro Ser Glu Gly Ile Gly Cys Arg Glu Met Leu Gly Pro 
            180                 185                 190         


Arg Arg Thr Phe Val Leu Ser Ala Leu Gln Pro Ser Pro Thr His Ser 
        195                 200                 205             


Ser Ser Asn Thr Gln Arg Leu Pro Asp Arg Val Thr Gly Val Asp Thr 
    210                 215                 220                 


Asp Pro His Phe Ile Ile His Val Pro Gln Lys Glu Asp Thr Leu Cys 
225                 230                 235                 240 


Phe Asn Ile Asn Glu Glu Pro Gly Val Ile Leu Ser Leu Val Gln Asp 
                245                 250                 255     


Pro Asn Thr Gly Phe Ser Val Asn Gly Gln Leu Ile Gly Asn Lys Ala 
            260                 265                 270         


Arg Ser Pro Gly Gln His Asp Gly Thr Tyr Phe Gly Arg Leu Gly Ile 
        275                 280                 285             


Ala Asn Pro Ala Thr Asp Phe Gln Leu Glu Val Thr Pro Gln Asn Ile 
    290                 295                 300                 


Thr Leu Asn Pro Gly Phe Gly Gly Pro Val Phe Ser Trp Arg Asp Gln 
305                 310                 315                 320 


Ala Val Leu Arg Gln Asp Gly Val Val Val Thr Ile Asn Lys Lys Arg 
                325                 330                 335     


Asn Leu Val Val Ser Val Asp Asp Gly Gly Thr Phe Glu Val Val Leu 
            340                 345                 350         


His Arg Val Trp Lys Gly Ser Ser Val His Gln Asp Phe Leu Gly Phe 
        355                 360                 365             


Tyr Val Leu Asp Ser His Arg Met Ser Ala Arg Thr His Gly Leu Leu 
    370                 375                 380                 


Gly Gln Phe Phe His Pro Ile Gly Phe Glu Val Ser Asp Ile His Pro 
385                 390                 395                 400 


Gly Ser Asp Pro Thr Lys Pro Asp Ala Thr Met Val Val Arg Asn Arg 
                405                 410                 415     


Arg Leu Thr Val Thr Arg Gly Leu Gln Lys Asp Tyr Ser Lys Asp Pro 
            420                 425                 430         


Trp His Gly Ala Glu Val Ser Cys Trp Phe Ile His Asn Asn Gly Ala 
        435                 440                 445             


Gly Leu Ile Asp Gly Ala Tyr Thr Asp Tyr Ile Val Pro Asp Ile Phe 
    450                 455                 460                 


<210>  7321
<211>  74
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7321

Xaa Met Lys Val Asp Arg Glu Glu Arg Ala Asn Leu Ser Ser Gln Ala 
1               5                   10                  15      


Leu Gln Met Ser Leu Asp Tyr Gly Phe Val Thr Pro Leu Thr Ser Met 
            20                  25                  30          


Ser Ile Arg Gly Met Ala Asp Gln Asp Gly Leu Lys Pro Thr Ile Asp 
        35                  40                  45              


Lys Pro Ser Glu Asp Ser Pro Pro Leu Glu Met Leu Gly Pro Arg Arg 
    50                  55                  60                  


Thr Pro Ile Pro Ser Gly Cys Gln Thr Glu 
65                  70                  


<210>  7322
<211>  935
<212>  PRT
<213>  Homo Sapiens

<400>  7322

Met Lys Arg Leu Thr Cys Phe Phe Ile Cys Phe Phe Leu Ser Glu Val 
1               5                   10                  15      


Ser Gly Phe Glu Ile Pro Ile Asn Gly Leu Ser Glu Phe Val Asp Tyr 
            20                  25                  30          


Glu Asp Leu Val Glu Leu Ala Pro Gly Lys Phe Gln Leu Val Ala Glu 
        35                  40                  45              


Asn Arg Arg Tyr Gln Glu Glu Val Asp Gln Val Thr Leu Tyr Ser Tyr 
    50                  55                  60                  


Lys Val Gln Ser Thr Ile Thr Ser Arg Met Ala Thr Thr Met Ile Gln 
65                  70                  75                  80  


Ser Lys Val Val Asn Asn Ser Pro Gln Pro Gln Asn Val Val Phe Asp 
                85                  90                  95      


Val Gln Ile Pro Lys Gly Ala Phe Ile Ser Asn Phe Ser Met Thr Val 
            100                 105                 110         


Asp Gly Lys Thr Phe Arg Ser Ser Ile Lys Glu Lys Thr Val Gly Arg 
        115                 120                 125             


Ala Leu Tyr Ala Gln Ala Arg Ala Lys Gly Lys Thr Ala Gly Leu Val 
    130                 135                 140                 


Arg Ser Ser Ala Leu Asp Met Glu Asn Phe Arg Thr Glu Val Asn Val 
145                 150                 155                 160 


Leu Pro Gly Ala Lys Val Gln Phe Glu Leu His Tyr Gln Glu Val Lys 
                165                 170                 175     


Trp Arg Lys Leu Gly Ser Tyr Glu His Arg Ile Tyr Leu Gln Pro Gly 
            180                 185                 190         


Arg Leu Ala Lys His Leu Glu Val Asp Val Trp Val Ile Glu Pro Gln 
        195                 200                 205             


Gly Leu Arg Phe Leu His Val Pro Asp Thr Phe Glu Gly His Phe Asp 
    210                 215                 220                 


Gly Val Pro Val Ile Ser Lys Gly Gln Gln Lys Ala His Val Ser Phe 
225                 230                 235                 240 


Lys Pro Thr Val Ala Gln Gln Arg Ile Cys Pro Asn Cys Arg Glu Thr 
                245                 250                 255     


Ala Val Asp Gly Glu Leu Val Val Leu Tyr Asp Val Lys Arg Glu Glu 
            260                 265                 270         


Lys Ala Gly Glu Leu Glu Val Phe Asn Gly Tyr Phe Val His Phe Phe 
        275                 280                 285             


Ala Pro Asp Asn Leu Asp Pro Ile Pro Lys Asn Ile Leu Phe Val Ile 
    290                 295                 300                 


Asp Val Ser Gly Ser Met Trp Gly Val Lys Met Lys Gln Thr Val Glu 
305                 310                 315                 320 


Ala Met Lys Thr Ile Leu Asp Asp Leu Arg Ala Glu Asp His Phe Ser 
                325                 330                 335     


Val Ile Asp Phe Asn Gln Asn Ile Arg Thr Trp Arg Asn Asp Leu Ile 
            340                 345                 350         


Ser Ala Thr Lys Thr Gln Val Ala Asp Ala Lys Arg Tyr Ile Glu Lys 
        355                 360                 365             


Ile Gln Pro Ser Gly Gly Thr Asn Ile Asn Glu Ala Leu Leu Arg Ala 
    370                 375                 380                 


Ile Phe Ile Leu Asn Glu Ala Asn Asn Leu Gly Leu Leu Asp Pro Asn 
385                 390                 395                 400 


Ser Val Ser Leu Ile Ile Leu Val Ser Asp Gly Asp Pro Thr Val Gly 
                405                 410                 415     


Glu Leu Lys Leu Ser Lys Ile Gln Lys Asn Val Lys Glu Asn Ile Gln 
            420                 425                 430         


Asp Asn Ile Ser Leu Phe Ser Leu Gly Met Gly Phe Asp Val Asp Tyr 
        435                 440                 445             


Asp Phe Leu Lys Arg Leu Ser Asn Glu Asn His Gly Ile Ala Gln Arg 
    450                 455                 460                 


Ile Tyr Gly Asn Gln Asp Thr Ser Ser Gln Leu Lys Lys Phe Tyr Asn 
465                 470                 475                 480 


Gln Val Ser Thr Pro Leu Leu Arg Asn Val Gln Phe Asn Tyr Pro His 
                485                 490                 495     


Thr Ser Val Thr Asp Val Thr Gln Asn Asn Phe His Asn Tyr Phe Gly 
            500                 505                 510         


Gly Ser Glu Ile Val Val Ala Gly Lys Phe Asp Pro Ala Lys Leu Asp 
        515                 520                 525             


Gln Ile Glu Ser Val Ile Thr Ala Thr Ser Ala Asn Thr Gln Leu Val 
    530                 535                 540                 


Leu Glu Thr Leu Ala Gln Met Asp Asp Leu Gln Asp Phe Leu Ser Lys 
545                 550                 555                 560 


Asp Lys His Ala Asp Pro Asp Phe Thr Arg Lys Leu Trp Ala Tyr Leu 
                565                 570                 575     


Thr Ile Asn Gln Leu Leu Ala Glu Arg Ser Leu Ala Pro Thr Ala Ala 
            580                 585                 590         


Ala Lys Arg Arg Ile Thr Arg Ser Ile Leu Gln Met Ser Leu Asp His 
        595                 600                 605             


His Ile Val Thr Pro Leu Thr Ser Leu Val Ile Glu Asn Glu Ala Gly 
    610                 615                 620                 


Asp Glu Arg Met Leu Ala Asp Ala Pro Pro Gln Asp Pro Ser Cys Cys 
625                 630                 635                 640 


Ser Gly Ala Leu Tyr Tyr Gly Ser Lys Val Val Pro Asp Ser Thr Pro 
                645                 650                 655     


Ser Trp Ala Asn Pro Ser Pro Thr Pro Val Ile Ser Met Leu Ala Gln 
            660                 665                 670         


Gly Ser Gln Val Leu Glu Ser Thr Pro Pro Pro His Val Met Arg Val 
        675                 680                 685             


Glu Asn Asp Pro His Phe Ile Ile Tyr Leu Pro Lys Ser Gln Lys Asn 
    690                 695                 700                 


Ile Cys Phe Asn Ile Asp Ser Glu Pro Gly Lys Ile Leu Asn Leu Val 
705                 710                 715                 720 


Ser Asp Pro Glu Ser Gly Ile Val Val Asn Gly Gln Leu Val Gly Ala 
                725                 730                 735     


Lys Lys Pro Asn Asn Gly Lys Leu Ser Thr Tyr Phe Gly Lys Leu Gly 
            740                 745                 750         


Phe Tyr Phe Gln Ser Glu Asp Ile Lys Ile Glu Ile Ser Thr Glu Thr 
        755                 760                 765             


Ile Thr Leu Ser His Gly Ser Ser Thr Phe Ser Leu Ser Trp Ser Asp 
    770                 775                 780                 


Thr Ala Gln Val Thr Asn Gln Arg Val Gln Ile Ser Val Lys Lys Glu 
785                 790                 795                 800 


Lys Val Val Thr Ile Thr Leu Asp Lys Glu Met Ser Phe Ser Val Leu 
                805                 810                 815     


Leu His Arg Val Trp Lys Lys His Pro Val Asn Val Asp Phe Leu Gly 
            820                 825                 830         


Ile Tyr Ile Pro Pro Thr Asn Lys Phe Ser Pro Lys Ala His Gly Leu 
        835                 840                 845             


Ile Gly Gln Phe Met Gln Glu Pro Lys Ile His Ile Phe Asn Glu Arg 
    850                 855                 860                 


Pro Gly Lys Asp Pro Glu Lys Pro Glu Ala Ser Met Glu Val Lys Gly 
865                 870                 875                 880 


Gln Lys Leu Ile Ile Thr Arg Gly Leu Gln Lys Asp Tyr Arg Thr Asp 
                885                 890                 895     


Leu Val Phe Gly Thr Asp Val Thr Cys Trp Phe Val His Asn Ser Gly 
            900                 905                 910         


Lys Gly Phe Ile Asp Gly His Tyr Lys Asp Tyr Phe Val Pro Gln Leu 
        915                 920                 925             


Tyr Ser Phe Leu Lys Arg Pro 
    930                 935 


<210>  7323
<211>  946
<212>  PRT
<213>  Homo Sapiens

<400>  7323

Met Lys Arg Leu Thr Cys Phe Phe Ile Cys Phe Phe Leu Ser Glu Val 
1               5                   10                  15      


Ser Gly Phe Glu Ile Pro Ile Asn Gly Leu Ser Glu Phe Val Asp Tyr 
            20                  25                  30          


Glu Asp Leu Val Glu Leu Ala Pro Gly Lys Phe Gln Leu Val Ala Glu 
        35                  40                  45              


Asn Arg Arg Tyr Gln Arg Ser Leu Pro Gly Glu Ser Glu Glu Met Met 
    50                  55                  60                  


Glu Glu Val Asp Gln Val Thr Leu Tyr Ser Tyr Lys Val Gln Ser Thr 
65                  70                  75                  80  


Ile Thr Ser Arg Met Ala Thr Thr Met Ile Gln Ser Lys Val Val Asn 
                85                  90                  95      


Asn Ser Pro Gln Pro Gln Asn Val Val Phe Asp Val Gln Ile Pro Lys 
            100                 105                 110         


Gly Ala Phe Ile Ser Asn Phe Ser Met Thr Val Asp Gly Lys Thr Phe 
        115                 120                 125             


Arg Ser Ser Ile Lys Glu Lys Thr Val Gly Arg Ala Leu Tyr Ala Gln 
    130                 135                 140                 


Ala Arg Ala Lys Gly Lys Thr Ala Gly Leu Val Arg Ser Ser Ala Leu 
145                 150                 155                 160 


Asp Met Glu Asn Phe Arg Thr Glu Val Asn Val Leu Pro Gly Ala Lys 
                165                 170                 175     


Val Gln Phe Glu Leu His Tyr Gln Glu Val Lys Trp Arg Lys Leu Gly 
            180                 185                 190         


Ser Tyr Glu His Arg Ile Tyr Leu Gln Pro Gly Arg Leu Ala Lys His 
        195                 200                 205             


Leu Glu Val Asp Val Trp Val Ile Glu Pro Gln Gly Leu Arg Phe Leu 
    210                 215                 220                 


His Val Pro Asp Thr Phe Glu Gly His Phe Asp Gly Val Pro Val Ile 
225                 230                 235                 240 


Ser Lys Gly Gln Gln Lys Ala His Val Ser Phe Lys Pro Thr Val Ala 
                245                 250                 255     


Gln Gln Arg Ile Cys Pro Asn Cys Arg Glu Thr Ala Val Asp Gly Glu 
            260                 265                 270         


Leu Val Val Leu Tyr Asp Val Lys Arg Glu Glu Lys Ala Gly Glu Leu 
        275                 280                 285             


Glu Val Phe Asn Gly Tyr Phe Val His Phe Phe Ala Pro Asp Asn Leu 
    290                 295                 300                 


Asp Pro Ile Pro Lys Asn Ile Leu Phe Val Ile Asp Val Ser Gly Ser 
305                 310                 315                 320 


Met Trp Gly Val Lys Met Lys Gln Thr Val Glu Ala Met Lys Thr Ile 
                325                 330                 335     


Leu Asp Asp Leu Arg Ala Glu Asp His Phe Ser Val Ile Asp Phe Asn 
            340                 345                 350         


Gln Asn Ile Arg Thr Trp Arg Asn Asp Leu Ile Ser Ala Thr Lys Thr 
        355                 360                 365             


Gln Val Ala Asp Ala Lys Arg Tyr Ile Glu Lys Ile Gln Pro Ser Gly 
    370                 375                 380                 


Gly Thr Asn Ile Asn Glu Ala Leu Leu Arg Ala Ile Phe Ile Leu Asn 
385                 390                 395                 400 


Glu Ala Asn Asn Leu Gly Leu Leu Asp Pro Asn Ser Val Ser Leu Ile 
                405                 410                 415     


Ile Leu Val Ser Asp Gly Asp Pro Thr Val Gly Glu Leu Lys Leu Ser 
            420                 425                 430         


Lys Ile Gln Lys Asn Val Lys Glu Asn Ile Gln Asp Asn Ile Ser Leu 
        435                 440                 445             


Phe Ser Leu Gly Met Gly Phe Asp Val Asp Tyr Asp Phe Leu Lys Arg 
    450                 455                 460                 


Leu Ser Asn Glu Asn His Gly Ile Ala Gln Arg Ile Tyr Gly Asn Gln 
465                 470                 475                 480 


Asp Thr Ser Ser Gln Leu Lys Lys Phe Tyr Asn Gln Val Ser Thr Pro 
                485                 490                 495     


Leu Leu Arg Asn Val Gln Phe Asn Tyr Pro His Thr Ser Val Thr Asp 
            500                 505                 510         


Val Thr Gln Asn Asn Phe His Asn Tyr Phe Gly Gly Ser Glu Ile Val 
        515                 520                 525             


Val Ala Gly Lys Phe Asp Pro Ala Lys Leu Asp Gln Ile Glu Ser Val 
    530                 535                 540                 


Ile Thr Ala Thr Ser Ala Asn Thr Gln Leu Val Leu Glu Thr Leu Ala 
545                 550                 555                 560 


Gln Met Asp Asp Leu Gln Asp Phe Leu Ser Lys Asp Lys His Ala Asp 
                565                 570                 575     


Pro Asp Phe Thr Arg Lys Leu Trp Ala Tyr Leu Thr Ile Asn Gln Leu 
            580                 585                 590         


Leu Ala Glu Arg Ser Leu Ala Pro Thr Ala Ala Ala Lys Arg Arg Ile 
        595                 600                 605             


Thr Arg Ser Ile Leu Gln Met Ser Leu Asp His His Ile Val Thr Pro 
    610                 615                 620                 


Leu Thr Ser Leu Val Ile Glu Asn Glu Ala Gly Asp Glu Arg Met Leu 
625                 630                 635                 640 


Ala Asp Ala Pro Pro Gln Asp Pro Ser Cys Cys Ser Gly Ala Leu Tyr 
                645                 650                 655     


Tyr Gly Ser Lys Val Val Pro Asp Ser Thr Pro Ser Trp Ala Asn Pro 
            660                 665                 670         


Ser Pro Thr Pro Val Ile Ser Met Leu Ala Gln Gly Ser Gln Val Leu 
        675                 680                 685             


Glu Ser Thr Pro Pro Pro His Val Met Arg Val Glu Asn Asp Pro His 
    690                 695                 700                 


Phe Ile Ile Tyr Leu Pro Lys Ser Gln Lys Asn Ile Cys Phe Asn Ile 
705                 710                 715                 720 


Asp Ser Glu Pro Gly Lys Ile Leu Asn Leu Val Ser Asp Pro Glu Ser 
                725                 730                 735     


Gly Ile Val Val Asn Gly Gln Leu Val Gly Ala Lys Lys Pro Asn Asn 
            740                 745                 750         


Gly Lys Leu Ser Thr Tyr Phe Gly Lys Leu Gly Phe Tyr Phe Gln Ser 
        755                 760                 765             


Glu Asp Ile Lys Ile Glu Ile Ser Thr Glu Thr Ile Thr Leu Ser His 
    770                 775                 780                 


Gly Ser Ser Thr Phe Ser Leu Ser Trp Ser Asp Thr Ala Gln Val Thr 
785                 790                 795                 800 


Asn Gln Arg Val Gln Ile Ser Val Lys Lys Glu Lys Val Val Thr Ile 
                805                 810                 815     


Thr Leu Asp Lys Glu Met Ser Phe Ser Val Leu Leu His Arg Val Trp 
            820                 825                 830         


Lys Lys His Pro Val Asn Val Asp Phe Leu Gly Ile Tyr Ile Pro Pro 
        835                 840                 845             


Thr Asn Lys Phe Ser Pro Lys Ala His Gly Leu Ile Gly Gln Phe Met 
    850                 855                 860                 


Gln Glu Pro Lys Ile His Ile Phe Asn Glu Arg Pro Gly Lys Asp Pro 
865                 870                 875                 880 


Glu Lys Pro Glu Ala Ser Met Glu Val Lys Gly Gln Lys Leu Ile Ile 
                885                 890                 895     


Thr Arg Gly Leu Gln Lys Asp Tyr Arg Thr Asp Leu Val Phe Gly Thr 
            900                 905                 910         


Asp Val Thr Cys Trp Phe Val His Asn Ser Gly Lys Gly Phe Ile Asp 
        915                 920                 925             


Gly His Tyr Lys Asp Tyr Phe Val Pro Gln Leu Tyr Ser Phe Leu Lys 
    930                 935                 940                 


Arg Pro 
945     


<210>  7324
<211>  237
<212>  PRT
<213>  Homo Sapiens

<400>  7324

Met Lys Arg Leu Thr Cys Phe Phe Ile Cys Phe Phe Leu Ser Glu Val 
1               5                   10                  15      


Ser Gly Phe Glu Ile Pro Ile Asn Gly Leu Ser Glu Arg Ser Leu Pro 
            20                  25                  30          


Gly Glu Ser Glu Glu Met Met Glu Glu Val Asp Gln Val Thr Leu Tyr 
        35                  40                  45              


Ser Tyr Lys Val Gln Ser Thr Ile Thr Ser Arg Met Ala Thr Thr Met 
    50                  55                  60                  


Ile Gln Ser Lys Val Val Asn Asn Ser Pro Gln Pro Gln Asn Val Val 
65                  70                  75                  80  


Phe Asp Val Gln Ile Pro Lys Gly Ala Phe Ile Ser Asn Phe Ser Met 
                85                  90                  95      


Thr Val Asp Gly Lys Thr Phe Arg Ser Ser Ile Lys Glu Lys Thr Val 
            100                 105                 110         


Gly Arg Ala Leu Tyr Ala Gln Ala Arg Ala Lys Gly Lys Thr Ala Gly 
        115                 120                 125             


Leu Val Arg Ser Ser Ala Leu Asp Met Glu Asn Phe Arg Thr Glu Val 
    130                 135                 140                 


Asn Val Leu Pro Gly Ala Lys Val Gln Phe Glu Leu His Tyr Gln Glu 
145                 150                 155                 160 


Val Lys Trp Arg Lys Leu Gly Ser Tyr Glu His Arg Ile Tyr Leu Gln 
                165                 170                 175     


Pro Gly Arg Leu Ala Lys His Leu Glu Val Asp Val Trp Val Ile Glu 
            180                 185                 190         


Pro Gln Gly Leu Arg Phe Leu His Val Pro Asp Thr Phe Glu Gly His 
        195                 200                 205             


Phe Asp Gly Val Pro Val Ile Ser Lys Gly Gln Gln Lys Ala His Val 
    210                 215                 220                 


Ser Phe Lys Pro Thr Val Ala Gln Gln Arg Ile Cys Pro 
225                 230                 235         


<210>  7325
<211>  698
<212>  PRT
<213>  Homo Sapiens

<400>  7325

Met Ala Phe Ala Trp Trp Pro Cys Leu Ile Leu Ala Leu Leu Ser Ser 
1               5                   10                  15      


Leu Ala Ala Ser Gly Phe Pro Arg Ser Pro Phe Arg Leu Leu Gly Lys 
            20                  25                  30          


Arg Ser Leu Pro Glu Gly Val Ala Asn Gly Ile Glu Val Tyr Ser Thr 
        35                  40                  45              


Lys Ile Asn Ser Lys Val Thr Ser Arg Phe Ala His Asn Val Val Thr 
    50                  55                  60                  


Met Arg Ala Val Asn Arg Ala Asp Thr Ala Lys Glu Val Ser Phe Asp 
65                  70                  75                  80  


Val Glu Leu Pro Lys Thr Ala Phe Ile Thr Asn Phe Thr Leu Thr Ile 
                85                  90                  95      


Asp Gly Val Thr Tyr Pro Gly Asn Val Lys Glu Lys Glu Val Ala Lys 
            100                 105                 110         


Lys Gln Tyr Glu Lys Ala Val Ser Gln Gly Lys Thr Ala Gly Leu Val 
        115                 120                 125             


Lys Ala Ser Gly Arg Lys Leu Glu Lys Phe Thr Val Ser Val Asn Val 
    130                 135                 140                 


Ala Ala Gly Ser Lys Val Thr Phe Glu Leu Thr Tyr Glu Glu Leu Leu 
145                 150                 155                 160 


Lys Arg His Lys Gly Lys Tyr Glu Met Tyr Leu Lys Val Gln Pro Lys 
                165                 170                 175     


Gln Leu Val Lys His Phe Glu Ile Glu Val Asp Ile Phe Glu Pro Gln 
            180                 185                 190         


Gly Ile Ser Met Leu Asp Ala Glu Ala Ser Phe Ile Thr Asn Asp Leu 
        195                 200                 205             


Leu Gly Ser Ala Leu Thr Lys Ser Phe Ser Gly Lys Lys Gly His Val 
    210                 215                 220                 


Ser Phe Lys Pro Ser Leu Asp Gln Gln Arg Ser Cys Pro Thr Cys Thr 
225                 230                 235                 240 


Asp Ser Leu Leu Asn Gly Asp Phe Thr Ile Thr Tyr Asp Val Asn Arg 
                245                 250                 255     


Glu Ser Pro Gly Asn Val Gln Ile Val Asn Gly Tyr Phe Val His Phe 
            260                 265                 270         


Phe Ala Pro Gln Gly Leu Pro Val Val Pro Lys Asn Val Ala Phe Val 
        275                 280                 285             


Ile Asp Ile Ser Gly Ser Met Ala Gly Arg Lys Leu Glu Gln Thr Lys 
    290                 295                 300                 


Glu Ala Leu Leu Arg Ile Leu Glu Asp Met Gln Glu Glu Asp Tyr Leu 
305                 310                 315                 320 


Asn Phe Ile Leu Phe Ser Gly Asp Val Ser Thr Trp Lys Glu His Leu 
                325                 330                 335     


Val Gln Ala Thr Pro Glu Asn Leu Gln Glu Ala Arg Thr Phe Val Lys 
            340                 345                 350         


Ser Met Glu Asp Lys Gly Met Thr Asn Ile Asn Asp Gly Leu Leu Arg 
        355                 360                 365             


Gly Ile Ser Met Leu Asn Lys Ala Arg Glu Glu His Arg Ile Pro Glu 
    370                 375                 380                 


Arg Ser Thr Ser Ile Val Ile Met Leu Thr Asp Gly Asp Ala Asn Val 
385                 390                 395                 400 


Gly Glu Ser Arg Pro Glu Lys Ile Gln Glu Asn Val Arg Asn Ala Ile 
                405                 410                 415     


Gly Gly Lys Phe Pro Leu Tyr Asn Leu Gly Phe Gly Asn Asn Leu Asn 
            420                 425                 430         


Tyr Asn Phe Leu Glu Asn Met Ala Leu Glu Asn His Gly Phe Ala Arg 
        435                 440                 445             


Arg Ile Tyr Glu Asp Ser Asp Ala Asp Leu Gln Leu Gln Gly Phe Tyr 
    450                 455                 460                 


Glu Glu Val Ala Asn Pro Leu Leu Thr Gly Val Glu Met Glu Tyr Pro 
465                 470                 475                 480 


Glu Asn Ala Ile Leu Asp Leu Thr Gln Asn Thr Tyr Gln His Phe Tyr 
                485                 490                 495     


Asp Gly Ser Glu Ile Val Val Ala Gly Arg Leu Val Asp Glu Asp Met 
            500                 505                 510         


Asn Ser Phe Lys Ala Asp Val Lys Gly His Gly Ala Thr Asn Asp Leu 
        515                 520                 525             


Thr Phe Thr Glu Glu Val Thr Thr Glu Lys Ile Thr Leu Trp Asn Arg 
    530                 535                 540                 


Ala Val Pro Ser Thr Phe Ser Trp Leu Asp Thr Val Thr Val Thr Gln 
545                 550                 555                 560 


Asp Gly Leu Ser Met Met Ile Asn Arg Lys Asn Met Val Val Ser Phe 
                565                 570                 575     


Gly Asp Gly Val Thr Phe Val Val Val Leu His Gln Val Trp Lys Lys 
            580                 585                 590         


His Pro Val His Arg Asp Phe Leu Gly Phe Tyr Val Val Asp Ser His 
        595                 600                 605             


Arg Met Ser Ala Gln Thr His Gly Leu Leu Gly Gln Phe Phe Gln Pro 
    610                 615                 620                 


Phe Asp Phe Lys Val Ser Asp Ile Arg Pro Gly Ser Asp Pro Thr Lys 
625                 630                 635                 640 


Pro Asp Ala Thr Leu Val Val Lys Asn His Gln Leu Ile Val Thr Arg 
                645                 650                 655     


Gly Ser Gln Lys Asp Tyr Arg Lys Asp Ala Ser Ile Gly Thr Lys Val 
            660                 665                 670         


Val Cys Trp Phe Val His Asn Asn Gly Glu Gly Leu Ile Asp Gly Val 
        675                 680                 685             


His Thr Asp Tyr Ile Val Pro Asn Leu Phe 
    690                 695             


<210>  7326
<211>  890
<212>  PRT
<213>  Homo Sapiens

<400>  7326

Met Ala Phe Ala Trp Trp Pro Cys Leu Ile Leu Ala Leu Leu Ser Ser 
1               5                   10                  15      


Leu Ala Ala Ser Gly Phe Pro Arg Ser Pro Phe Arg Leu Leu Gly Lys 
            20                  25                  30          


Arg Ser Leu Pro Glu Gly Val Ala Asn Gly Ile Glu Val Tyr Ser Thr 
        35                  40                  45              


Lys Ile Asn Ser Lys Val Thr Ser Arg Phe Ala His Asn Val Val Thr 
    50                  55                  60                  


Met Arg Ala Val Asn Arg Ala Asp Thr Ala Lys Glu Val Ser Phe Asp 
65                  70                  75                  80  


Val Glu Leu Pro Lys Thr Ala Phe Ile Thr Asn Phe Thr Leu Thr Ile 
                85                  90                  95      


Asp Gly Val Thr Tyr Pro Gly Asn Val Lys Glu Lys Glu Val Ala Lys 
            100                 105                 110         


Lys Gln Tyr Glu Lys Ala Val Ser Gln Gly Lys Thr Ala Gly Leu Val 
        115                 120                 125             


Lys Ala Ser Gly Arg Lys Leu Glu Lys Phe Thr Val Ser Val Asn Val 
    130                 135                 140                 


Ala Ala Gly Ser Lys Val Thr Phe Glu Leu Thr Tyr Glu Glu Leu Leu 
145                 150                 155                 160 


Lys Arg His Lys Gly Lys Tyr Glu Met Tyr Leu Lys Val Gln Pro Lys 
                165                 170                 175     


Gln Leu Val Lys His Phe Glu Ile Glu Val Asp Ile Phe Glu Pro Gln 
            180                 185                 190         


Gly Ile Ser Met Leu Asp Ala Glu Ala Ser Phe Ile Thr Asn Asp Leu 
        195                 200                 205             


Leu Gly Ser Ala Leu Thr Lys Ser Phe Ser Gly Lys Lys Gly His Val 
    210                 215                 220                 


Ser Phe Lys Pro Ser Leu Asp Gln Gln Arg Ser Cys Pro Thr Cys Thr 
225                 230                 235                 240 


Asp Ser Leu Leu Asn Gly Asp Phe Thr Ile Thr Tyr Asp Val Asn Arg 
                245                 250                 255     


Glu Ser Pro Gly Asn Val Gln Ile Val Asn Gly Tyr Phe Val His Phe 
            260                 265                 270         


Phe Ala Pro Gln Gly Leu Pro Val Val Pro Lys Asn Val Ala Phe Val 
        275                 280                 285             


Ile Asp Ile Ser Gly Ser Met Ala Gly Arg Lys Leu Glu Gln Thr Lys 
    290                 295                 300                 


Glu Ala Leu Leu Arg Ile Leu Glu Asp Met Gln Glu Glu Asp Tyr Leu 
305                 310                 315                 320 


Asn Phe Ile Leu Phe Ser Gly Asp Val Ser Thr Trp Lys Glu His Leu 
                325                 330                 335     


Val Gln Ala Thr Pro Glu Asn Leu Gln Glu Ala Arg Thr Phe Val Lys 
            340                 345                 350         


Ser Met Glu Asp Lys Gly Met Thr Asn Ile Asn Asp Gly Leu Leu Arg 
        355                 360                 365             


Gly Ile Ser Met Leu Asn Lys Ala Arg Glu Glu His Arg Ile Pro Glu 
    370                 375                 380                 


Arg Ser Thr Ser Ile Val Ile Met Leu Thr Asp Gly Asp Ala Asn Val 
385                 390                 395                 400 


Gly Glu Ser Arg Pro Glu Lys Ile Gln Glu Asn Val Arg Asn Ala Ile 
                405                 410                 415     


Gly Gly Lys Phe Pro Leu Tyr Asn Leu Gly Phe Gly Asn Asn Leu Asn 
            420                 425                 430         


Tyr Asn Phe Leu Glu Asn Met Ala Leu Glu Asn His Gly Phe Ala Arg 
        435                 440                 445             


Arg Ile Tyr Glu Asp Ser Asp Ala Asp Leu Gln Leu Gln Gly Phe Tyr 
    450                 455                 460                 


Glu Glu Val Ala Asn Pro Leu Leu Thr Gly Val Glu Met Glu Tyr Pro 
465                 470                 475                 480 


Glu Asn Ala Ile Leu Asp Leu Thr Gln Asn Thr Tyr Gln His Phe Tyr 
                485                 490                 495     


Asp Gly Ser Glu Ile Val Val Ala Gly Arg Leu Val Asp Glu Asp Met 
            500                 505                 510         


Asn Ser Phe Lys Ala Asp Val Lys Gly His Gly Ala Thr Asn Asp Leu 
        515                 520                 525             


Thr Phe Thr Glu Glu Val Asp Met Lys Glu Met Glu Lys Ala Leu Gln 
    530                 535                 540                 


Glu Arg Asp Tyr Ile Phe Gly Asn Tyr Ile Glu Arg Leu Trp Ala Tyr 
545                 550                 555                 560 


Leu Thr Ile Glu Gln Leu Leu Glu Lys Arg Lys Asn Ala His Gly Glu 
                565                 570                 575     


Glu Lys Glu Asn Leu Thr Ala Arg Ala Leu Asp Leu Ser Leu Lys Tyr 
            580                 585                 590         


His Phe Val Thr Pro Leu Thr Ser Met Val Val Thr Lys Pro Glu Asp 
        595                 600                 605             


Asn Glu Asp Glu Arg Ala Ile Ala Asp Lys Pro Gly Glu Asp Ala Glu 
    610                 615                 620                 


Ala Thr Pro Val Ser Pro Ala Met Ser Tyr Leu Thr Ser Tyr Gln Pro 
625                 630                 635                 640 


Pro Gln Asn Pro Tyr Tyr Tyr Val Asp Gly Asp Pro His Phe Ile Ile 
                645                 650                 655     


Gln Ile Pro Glu Lys Asp Asp Ala Leu Cys Phe Asn Ile Asp Glu Ala 
            660                 665                 670         


Pro Gly Thr Val Leu Arg Leu Ile Gln Asp Ala Val Thr Gly Leu Thr 
        675                 680                 685             


Val Asn Gly Gln Ile Thr Gly Asp Lys Arg Gly Ser Pro Asp Ser Lys 
    690                 695                 700                 


Thr Arg Lys Thr Tyr Phe Gly Lys Leu Gly Ile Ala Asn Ala Gln Met 
705                 710                 715                 720 


Asp Phe Gln Val Glu Val Thr Thr Glu Lys Ile Thr Leu Trp Asn Arg 
                725                 730                 735     


Ala Val Pro Ser Thr Phe Ser Trp Leu Asp Thr Val Thr Val Thr Gln 
            740                 745                 750         


Asp Gly Leu Ser Met Met Ile Asn Arg Lys Asn Met Val Val Ser Phe 
        755                 760                 765             


Gly Asp Gly Val Thr Phe Val Val Val Leu His Gln Val Trp Lys Lys 
    770                 775                 780                 


His Pro Val His Arg Asp Phe Leu Gly Phe Tyr Val Val Asp Ser His 
785                 790                 795                 800 


Arg Met Ser Ala Gln Thr His Gly Leu Leu Gly Gln Phe Phe Gln Pro 
                805                 810                 815     


Phe Asp Phe Lys Val Ser Asp Ile Arg Pro Gly Ser Asp Pro Thr Lys 
            820                 825                 830         


Pro Asp Ala Thr Leu Val Val Lys Asn His Gln Leu Ile Val Thr Arg 
        835                 840                 845             


Gly Ser Gln Lys Asp Tyr Arg Lys Asp Ala Ser Ile Gly Thr Lys Val 
    850                 855                 860                 


Val Cys Trp Phe Val His Asn Asn Gly Glu Gly Leu Ile Asp Gly Val 
865                 870                 875                 880 


His Thr Asp Tyr Ile Val Pro Asn Leu Phe 
                885                 890 


<210>  7327
<211>  670
<212>  PRT
<213>  Homo Sapiens

<400>  7327

Met Ala Phe Ala Trp Trp Pro Cys Leu Ile Leu Ala Leu Leu Ser Ser 
1               5                   10                  15      


Leu Ala Ala Ser Gly Phe Pro Arg Ser Pro Phe Arg Leu Leu Gly Lys 
            20                  25                  30          


Arg Ser Leu Pro Glu Gly Val Ala Asn Gly Ile Glu Val Tyr Ser Thr 
        35                  40                  45              


Lys Ile Asn Ser Lys Val Thr Ser Arg Phe Ala His Asn Val Val Thr 
    50                  55                  60                  


Met Arg Ala Val Asn Arg Ala Asp Thr Ala Lys Glu Val Ser Phe Asp 
65                  70                  75                  80  


Val Glu Leu Pro Lys Thr Ala Phe Ile Thr Asn Phe Thr Leu Thr Ile 
                85                  90                  95      


Asp Gly Val Thr Tyr Pro Gly Asn Val Lys Glu Lys Glu Val Ala Lys 
            100                 105                 110         


Lys Gln Tyr Glu Lys Ala Val Ser Gln Gly Lys Thr Ala Gly Leu Val 
        115                 120                 125             


Lys Ala Ser Gly Arg Lys Leu Glu Lys Phe Thr Val Ser Val Asn Val 
    130                 135                 140                 


Ala Ala Gly Ser Lys Val Thr Phe Glu Leu Thr Tyr Glu Glu Leu Leu 
145                 150                 155                 160 


Lys Arg His Lys Gly Lys Tyr Glu Met Tyr Leu Lys Val Gln Pro Lys 
                165                 170                 175     


Gln Leu Val Lys His Phe Glu Ile Glu Val Asp Ile Phe Glu Pro Gln 
            180                 185                 190         


Gly Ile Ser Met Leu Asp Ala Glu Ala Ser Phe Ile Thr Asn Asp Leu 
        195                 200                 205             


Leu Gly Ser Ala Leu Thr Lys Ser Phe Ser Gly Lys Lys Gly His Val 
    210                 215                 220                 


Ser Phe Lys Pro Ser Leu Asp Gln Gln Arg Ser Cys Pro Thr Cys Thr 
225                 230                 235                 240 


Asp Ser Leu Leu Asn Gly Asp Phe Thr Ile Thr Tyr Asp Val Asn Arg 
                245                 250                 255     


Glu Ser Pro Gly Asn Val Gln Ile Val Asn Gly Tyr Phe Val His Phe 
            260                 265                 270         


Phe Ala Pro Gln Gly Leu Pro Val Val Pro Lys Asn Val Ala Phe Val 
        275                 280                 285             


Ile Asp Ile Ser Gly Ser Met Ala Gly Arg Lys Leu Glu Gln Thr Lys 
    290                 295                 300                 


Glu Ala Leu Leu Arg Ile Leu Glu Asp Met Gln Glu Glu Asp Tyr Leu 
305                 310                 315                 320 


Asn Phe Ile Leu Phe Ser Gly Asp Val Ser Thr Trp Lys Glu His Leu 
                325                 330                 335     


Val Gln Ala Thr Pro Glu Asn Leu Gln Glu Ala Arg Thr Phe Val Lys 
            340                 345                 350         


Ser Met Glu Asp Lys Gly Met Thr Asn Ile Asn Asp Gly Leu Leu Arg 
        355                 360                 365             


Gly Ile Ser Met Leu Asn Lys Ala Arg Glu Glu His Arg Ile Pro Glu 
    370                 375                 380                 


Arg Ser Thr Ser Ile Val Ile Met Leu Thr Asp Gly Asp Ala Asn Val 
385                 390                 395                 400 


Gly Glu Ser Arg Pro Glu Lys Ile Gln Glu Asn Val Arg Asn Ala Ile 
                405                 410                 415     


Gly Gly Lys Phe Pro Leu Tyr Asn Leu Gly Phe Gly Asn Asn Leu Asn 
            420                 425                 430         


Tyr Asn Phe Leu Glu Asn Met Ala Leu Glu Asn His Gly Phe Ala Arg 
        435                 440                 445             


Arg Ile Tyr Glu Asp Ser Asp Ala Asp Leu Gln Leu Gln Gly Phe Tyr 
    450                 455                 460                 


Glu Glu Val Ala Asn Pro Leu Leu Thr Gly Val Glu Met Glu Tyr Pro 
465                 470                 475                 480 


Glu Asn Ala Ile Leu Asp Leu Thr Gln Asn Thr Tyr Gln His Phe Tyr 
                485                 490                 495     


Asp Gly Ser Glu Ile Val Val Ala Gly Arg Leu Val Asp Glu Asp Met 
            500                 505                 510         


Asn Ser Phe Lys Ala Asp Val Lys Gly His Gly Ala Thr Asn Asp Leu 
        515                 520                 525             


Thr Phe Thr Glu Glu Val Asp Met Lys Glu Met Glu Lys Ala Leu Gln 
    530                 535                 540                 


Glu Arg Asp Tyr Ile Phe Gly Asn Tyr Ile Glu Arg Leu Trp Ala Tyr 
545                 550                 555                 560 


Leu Thr Ile Glu Gln Leu Leu Glu Lys Arg Lys Asn Ala His Gly Glu 
                565                 570                 575     


Glu Lys Glu Asn Leu Thr Ala Arg Ala Leu Asp Leu Ser Leu Lys Tyr 
            580                 585                 590         


His Phe Val Thr Pro Leu Thr Ser Met Val Val Thr Lys Pro Glu Asp 
        595                 600                 605             


Asn Glu Asp Glu Arg Ala Ile Ala Asp Lys Pro Gly Glu Gly Gly Asp 
    610                 615                 620                 


Ser His Thr Gly Glu Pro Arg His Val Leu Pro Asp Gln Leu Pro Ala 
625                 630                 635                 640 


Ser Ser Lys Pro Leu Leu Leu Cys Gly Arg Gly Ser Pro Leu His His 
                645                 650                 655     


Pro Asn Ser Gly Glu Arg Arg Cys Pro Leu Leu Gln His Arg 
            660                 665                 670 


<210>  7328
<211>  930
<212>  PRT
<213>  Homo Sapiens

<400>  7328

Met Lys Pro Pro Arg Pro Val Arg Thr Cys Ser Lys Val Leu Val Leu 
1               5                   10                  15      


Leu Ser Leu Leu Ala Ile His Gln Thr Thr Thr Ala Glu Lys Asn Gly 
            20                  25                  30          


Ile Asp Ile Tyr Ser Leu Thr Val Asp Ser Arg Val Ser Ser Arg Phe 
        35                  40                  45              


Ala His Thr Val Val Thr Ser Arg Val Val Asn Arg Ala Asn Thr Val 
    50                  55                  60                  


Gln Glu Ala Thr Phe Gln Met Glu Leu Pro Lys Lys Ala Phe Ile Thr 
65                  70                  75                  80  


Asn Phe Ser Met Ile Ile Asp Gly Met Thr Tyr Pro Gly Ile Ile Lys 
                85                  90                  95      


Glu Lys Ala Glu Ala Gln Ala Gln Tyr Ser Ala Ala Val Ala Lys Gly 
            100                 105                 110         


Lys Ser Ala Gly Leu Val Lys Ala Thr Gly Arg Asn Met Glu Gln Phe 
        115                 120                 125             


Gln Val Ser Val Ser Val Ala Pro Asn Ala Lys Ile Thr Phe Glu Leu 
    130                 135                 140                 


Val Tyr Glu Glu Leu Leu Lys Arg Arg Leu Gly Val Tyr Glu Leu Leu 
145                 150                 155                 160 


Leu Lys Val Arg Pro Gln Gln Leu Val Lys His Leu Gln Met Asp Ile 
                165                 170                 175     


His Ile Phe Glu Pro Gln Gly Ile Ser Phe Leu Glu Thr Glu Ser Thr 
            180                 185                 190         


Phe Met Thr Asn Gln Leu Val Asp Ala Leu Thr Thr Trp Gln Asn Lys 
        195                 200                 205             


Thr Lys Ala His Ile Arg Phe Lys Pro Thr Leu Ser Gln Gln Gln Lys 
    210                 215                 220                 


Ser Pro Glu Gln Gln Glu Thr Val Leu Asp Gly Asn Leu Ile Ile Arg 
225                 230                 235                 240 


Tyr Asp Val Asp Arg Ala Ile Ser Gly Gly Ser Ile Gln Ile Glu Asn 
                245                 250                 255     


Gly Tyr Phe Val His Tyr Phe Ala Pro Glu Gly Leu Thr Thr Met Pro 
            260                 265                 270         


Lys Asn Val Val Phe Val Ile Asp Lys Ser Gly Ser Met Ser Gly Arg 
        275                 280                 285             


Lys Ile Gln Gln Thr Arg Glu Ala Leu Ile Lys Ile Leu Asp Asp Leu 
    290                 295                 300                 


Ser Pro Arg Asp Gln Phe Asn Leu Ile Val Phe Ser Thr Glu Ala Thr 
305                 310                 315                 320 


Gln Trp Arg Pro Ser Leu Val Pro Ala Ser Ala Glu Asn Val Asn Lys 
                325                 330                 335     


Ala Arg Ser Phe Ala Ala Gly Ile Gln Ala Leu Gly Gly Thr Asn Ile 
            340                 345                 350         


Asn Asp Ala Met Leu Met Ala Val Gln Leu Leu Asp Ser Ser Asn Gln 
        355                 360                 365             


Glu Glu Arg Leu Pro Glu Gly Ser Val Ser Leu Ile Ile Leu Leu Thr 
    370                 375                 380                 


Asp Gly Asp Pro Thr Val Gly Glu Thr Asn Pro Arg Ser Ile Gln Asn 
385                 390                 395                 400 


Asn Val Arg Glu Ala Val Ser Gly Arg Tyr Ser Leu Phe Cys Leu Gly 
                405                 410                 415     


Phe Gly Phe Asp Val Ser Tyr Ala Phe Leu Glu Lys Leu Ala Leu Asp 
            420                 425                 430         


Asn Gly Gly Leu Ala Arg Arg Ile His Glu Asp Ser Asp Ser Ala Leu 
        435                 440                 445             


Gln Leu Gln Asp Phe Tyr Gln Glu Val Ala Asn Pro Leu Leu Thr Ala 
    450                 455                 460                 


Val Thr Phe Glu Tyr Pro Ser Asn Ala Val Glu Glu Val Thr Gln Asn 
465                 470                 475                 480 


Asn Phe Arg Leu Leu Phe Lys Gly Ser Glu Met Val Val Ala Gly Lys 
                485                 490                 495     


Leu Gln Asp Arg Gly Pro Asp Val Leu Thr Ala Thr Val Ser Gly Lys 
            500                 505                 510         


Leu Pro Thr Gln Asn Ile Thr Phe Gln Thr Glu Ser Ser Val Ala Glu 
        515                 520                 525             


Gln Glu Ala Glu Phe Gln Ser Pro Lys Tyr Ile Phe His Asn Phe Met 
    530                 535                 540                 


Glu Arg Leu Trp Ala Tyr Leu Thr Ile Gln Gln Leu Leu Glu Gln Thr 
545                 550                 555                 560 


Val Ser Ala Ser Asp Ala Asp Gln Gln Ala Leu Arg Asn Gln Ala Leu 
                565                 570                 575     


Asn Leu Ser Leu Ala Tyr Ser Phe Val Thr Pro Leu Thr Ser Met Val 
            580                 585                 590         


Val Thr Lys Pro Asp Asp Gln Glu Gln Ser Gln Val Ala Glu Lys Pro 
        595                 600                 605             


Met Glu Gly Glu Ser Arg Asn Arg Asn Val His Ser Gly Ser Thr Phe 
    610                 615                 620                 


Phe Lys Tyr Tyr Leu Gln Gly Ala Lys Ile Pro Lys Pro Glu Ala Ser 
625                 630                 635                 640 


Phe Ser Pro Arg Arg Gly Trp Asn Arg Gln Ala Gly Ala Ala Gly Ser 
                645                 650                 655     


Arg Met Asn Phe Arg Pro Gly Val Leu Ser Ser Arg Gln Leu Gly Leu 
            660                 665                 670         


Pro Gly Pro Pro Asp Val Pro Asp His Ala Ala Tyr His Pro Phe Arg 
        675                 680                 685             


Arg Leu Ala Ile Leu Pro Ala Ser Ala Pro Pro Ala Thr Ser Asn Pro 
    690                 695                 700                 


Asp Pro Ala Val Ser Arg Val Met Asn Met Lys Ile Glu Glu Thr Thr 
705                 710                 715                 720 


Met Thr Thr Gln Thr Pro Ala Pro Ile Gln Ala Pro Ser Ala Ile Leu 
                725                 730                 735     


Pro Leu Pro Gly Gln Ser Val Glu Arg Leu Cys Val Asp Pro Arg His 
            740                 745                 750         


Arg Gln Gly Pro Val Asn Leu Leu Ser Asp Pro Glu Gln Gly Val Glu 
        755                 760                 765             


Val Thr Gly Gln Tyr Glu Arg Glu Lys Ala Gly Phe Ser Trp Ile Glu 
    770                 775                 780                 


Val Thr Phe Lys Asn Pro Leu Val Trp Val His Ala Ser Pro Glu His 
785                 790                 795                 800 


Val Val Val Thr Arg Asn Arg Arg Ser Ser Ala Tyr Lys Trp Lys Glu 
                805                 810                 815     


Thr Leu Phe Ser Val Met Pro Gly Leu Lys Met Thr Met Asp Lys Thr 
            820                 825                 830         


Gly Leu Leu Leu Leu Ser Asp Pro Asp Lys Val Thr Ile Gly Leu Leu 
        835                 840                 845             


Phe Trp Asp Gly Arg Gly Glu Gly Leu Arg Leu Leu Leu Arg Asp Thr 
    850                 855                 860                 


Asp Arg Phe Ser Ser His Val Gly Gly Thr Leu Gly Gln Phe Tyr Gln 
865                 870                 875                 880 


Glu Val Leu Trp Gly Ser Pro Ala Ala Ser Asp Asp Gly Arg Arg Thr 
                885                 890                 895     


Leu Arg Val Gln Gly Asn Asp His Ser Ala Thr Arg Glu Arg Arg Leu 
            900                 905                 910         


Asp Tyr Gln Glu Gly Pro Pro Gly Val Glu Ile Ser Cys Trp Ser Val 
        915                 920                 925             


Glu Leu 
    930 


<210>  7329
<211>  900
<212>  PRT
<213>  Homo Sapiens

<400>  7329

Met Lys Pro Pro Arg Pro Val Arg Thr Cys Ser Lys Val Leu Val Leu 
1               5                   10                  15      


Leu Ser Leu Leu Ala Ile His Gln Thr Thr Thr Ala Glu Lys Asn Gly 
            20                  25                  30          


Ile Asp Ile Tyr Ser Leu Thr Val Asp Ser Arg Val Ser Ser Arg Phe 
        35                  40                  45              


Ala His Thr Val Val Thr Ser Arg Val Val Asn Arg Ala Asn Thr Val 
    50                  55                  60                  


Gln Glu Ala Thr Phe Gln Met Glu Leu Pro Lys Lys Ala Phe Ile Thr 
65                  70                  75                  80  


Asn Phe Ser Met Ile Ile Asp Gly Met Thr Tyr Pro Gly Ile Ile Lys 
                85                  90                  95      


Glu Lys Ala Glu Ala Gln Ala Gln Tyr Ser Ala Ala Val Ala Lys Gly 
            100                 105                 110         


Lys Ser Ala Gly Leu Val Lys Ala Thr Gly Arg Asn Met Glu Gln Phe 
        115                 120                 125             


Gln Val Ser Val Ser Val Ala Pro Asn Ala Lys Ile Thr Phe Glu Leu 
    130                 135                 140                 


Val Tyr Glu Glu Leu Leu Lys Arg Arg Leu Gly Val Tyr Glu Leu Leu 
145                 150                 155                 160 


Leu Lys Val Arg Pro Gln Gln Leu Val Lys His Leu Gln Met Asp Ile 
                165                 170                 175     


His Ile Phe Glu Pro Gln Gly Ile Ser Phe Leu Glu Thr Glu Ser Thr 
            180                 185                 190         


Phe Met Thr Asn Gln Leu Val Asp Ala Leu Thr Thr Trp Gln Asn Lys 
        195                 200                 205             


Thr Lys Ala His Ile Arg Phe Lys Pro Thr Leu Ser Gln Gln Gln Lys 
    210                 215                 220                 


Ser Pro Glu Gln Gln Glu Thr Val Leu Asp Gly Asn Leu Ile Ile Arg 
225                 230                 235                 240 


Tyr Asp Val Asp Arg Ala Ile Ser Gly Gly Ser Ile Gln Ile Glu Asn 
                245                 250                 255     


Gly Tyr Phe Val His Tyr Phe Ala Pro Glu Gly Leu Thr Thr Met Pro 
            260                 265                 270         


Lys Asn Val Val Phe Val Ile Asp Lys Ser Gly Ser Met Ser Gly Arg 
        275                 280                 285             


Lys Ile Gln Gln Thr Arg Glu Ala Leu Ile Lys Ile Leu Asp Asp Leu 
    290                 295                 300                 


Ser Pro Arg Asp Gln Phe Asn Leu Ile Val Phe Ser Thr Glu Ala Thr 
305                 310                 315                 320 


Gln Trp Arg Pro Ser Leu Val Pro Ala Ser Ala Glu Asn Val Asn Lys 
                325                 330                 335     


Ala Arg Ser Phe Ala Ala Gly Ile Gln Ala Leu Gly Gly Thr Asn Ile 
            340                 345                 350         


Asn Asp Ala Met Leu Met Ala Val Gln Leu Leu Asp Ser Ser Asn Gln 
        355                 360                 365             


Glu Glu Arg Leu Pro Glu Gly Ser Val Ser Leu Ile Ile Leu Leu Thr 
    370                 375                 380                 


Asp Gly Asp Pro Thr Val Gly Glu Thr Asn Pro Arg Ser Ile Gln Asn 
385                 390                 395                 400 


Asn Val Arg Glu Ala Val Ser Gly Arg Tyr Ser Leu Phe Cys Leu Gly 
                405                 410                 415     


Phe Gly Phe Asp Val Ser Tyr Ala Phe Leu Glu Lys Leu Ala Leu Asp 
            420                 425                 430         


Asn Gly Gly Leu Ala Arg Arg Ile His Glu Asp Ser Asp Ser Ala Leu 
        435                 440                 445             


Gln Leu Gln Asp Phe Tyr Gln Glu Val Ala Asn Pro Leu Leu Thr Ala 
    450                 455                 460                 


Val Thr Phe Glu Tyr Pro Ser Asn Ala Val Glu Glu Val Thr Gln Asn 
465                 470                 475                 480 


Asn Phe Arg Leu Leu Phe Lys Gly Ser Glu Met Val Val Ala Gly Lys 
                485                 490                 495     


Leu Gln Asp Arg Gly Pro Asp Val Leu Thr Ala Thr Val Ser Gly Lys 
            500                 505                 510         


Leu Pro Thr Gln Asn Ile Thr Phe Gln Thr Glu Ser Ser Val Ala Glu 
        515                 520                 525             


Gln Glu Ala Glu Phe Gln Ser Pro Lys Tyr Ile Phe His Asn Phe Met 
    530                 535                 540                 


Glu Arg Leu Trp Ala Tyr Leu Thr Ile Gln Gln Leu Leu Glu Gln Thr 
545                 550                 555                 560 


Val Ser Ala Ser Asp Ala Asp Gln Gln Ala Leu Arg Asn Gln Ala Leu 
                565                 570                 575     


Asn Leu Ser Leu Ala Tyr Ser Phe Val Thr Pro Leu Thr Ser Met Val 
            580                 585                 590         


Val Thr Lys Pro Asp Asp Gln Glu Gln Ser Gln Val Ala Glu Lys Pro 
        595                 600                 605             


Met Glu Gly Glu Ser Arg Asn Arg Asn Val His Ser Ala Gly Ala Ala 
    610                 615                 620                 


Gly Ser Arg Met Asn Phe Arg Pro Gly Val Leu Ser Ser Arg Gln Leu 
625                 630                 635                 640 


Gly Leu Pro Gly Pro Pro Asp Val Pro Asp His Ala Ala Tyr His Pro 
                645                 650                 655     


Phe Arg Arg Leu Ala Ile Leu Pro Ala Ser Ala Pro Pro Ala Thr Ser 
            660                 665                 670         


Asn Pro Asp Pro Ala Val Ser Arg Val Met Asn Met Lys Ile Glu Glu 
        675                 680                 685             


Thr Thr Met Thr Thr Gln Thr Pro Ala Pro Ile Gln Ala Pro Ser Ala 
    690                 695                 700                 


Ile Leu Pro Leu Pro Gly Gln Ser Val Glu Arg Leu Cys Val Asp Pro 
705                 710                 715                 720 


Arg His Arg Gln Gly Pro Val Asn Leu Leu Ser Asp Pro Glu Gln Gly 
                725                 730                 735     


Val Glu Val Thr Gly Gln Tyr Glu Arg Glu Lys Ala Gly Phe Ser Trp 
            740                 745                 750         


Ile Glu Val Thr Phe Lys Asn Pro Leu Val Trp Val His Ala Ser Pro 
        755                 760                 765             


Glu His Val Val Val Thr Arg Asn Arg Arg Ser Ser Ala Tyr Lys Trp 
    770                 775                 780                 


Lys Glu Thr Leu Phe Ser Val Met Pro Gly Leu Lys Met Thr Met Asp 
785                 790                 795                 800 


Lys Thr Gly Leu Leu Leu Leu Ser Asp Pro Asp Lys Val Thr Ile Gly 
                805                 810                 815     


Leu Leu Phe Trp Asp Gly Arg Gly Glu Gly Leu Arg Leu Leu Leu Arg 
            820                 825                 830         


Asp Thr Asp Arg Phe Ser Ser His Val Gly Gly Thr Leu Gly Gln Phe 
        835                 840                 845             


Tyr Gln Glu Val Leu Trp Gly Ser Pro Ala Ala Ser Asp Asp Gly Arg 
    850                 855                 860                 


Arg Thr Leu Arg Val Gln Gly Asn Asp His Ser Ala Thr Arg Glu Arg 
865                 870                 875                 880 


Arg Leu Asp Tyr Gln Glu Gly Pro Pro Gly Val Glu Ile Ser Cys Trp 
                885                 890                 895     


Ser Val Glu Leu 
            900 


<210>  7330
<211>  935
<212>  PRT
<213>  Homo Sapiens

<400>  7330

Met Lys Pro Pro Arg Pro Val Arg Thr Cys Ser Lys Val Leu Val Leu 
1               5                   10                  15      


Leu Ser Leu Leu Ala Ile His Gln Thr Thr Thr Ala Glu Lys Asn Gly 
            20                  25                  30          


Ile Asp Ile Tyr Ser Leu Thr Val Asp Ser Arg Val Ser Ser Arg Phe 
        35                  40                  45              


Ala His Thr Val Val Thr Ser Arg Val Val Asn Arg Ala Asn Thr Val 
    50                  55                  60                  


Gln Glu Ala Thr Phe Gln Met Glu Leu Pro Lys Lys Ala Phe Ile Thr 
65                  70                  75                  80  


Asn Phe Ser Met Ile Ile Asp Gly Met Thr Tyr Pro Gly Ile Ile Lys 
                85                  90                  95      


Glu Lys Ala Glu Ala Gln Ala Gln Tyr Ser Ala Ala Val Ala Lys Gly 
            100                 105                 110         


Lys Ser Ala Gly Leu Val Lys Ala Thr Gly Arg Asn Met Glu Gln Phe 
        115                 120                 125             


Gln Val Ser Val Ser Val Ala Pro Asn Ala Lys Ile Thr Phe Glu Leu 
    130                 135                 140                 


Val Tyr Glu Glu Leu Leu Lys Arg Arg Leu Gly Val Tyr Glu Leu Leu 
145                 150                 155                 160 


Leu Lys Val Arg Pro Gln Gln Leu Val Lys His Leu Gln Met Asp Ile 
                165                 170                 175     


His Ile Phe Glu Pro Gln Gly Ile Ser Phe Leu Glu Thr Glu Ser Thr 
            180                 185                 190         


Phe Met Thr Asn Gln Leu Val Asp Ala Leu Thr Thr Trp Gln Asn Lys 
        195                 200                 205             


Thr Lys Ala His Ile Arg Phe Lys Pro Thr Leu Ser Gln Gln Gln Lys 
    210                 215                 220                 


Ser Pro Glu Gln Gln Glu Thr Val Leu Asp Gly Asn Leu Ile Ile Arg 
225                 230                 235                 240 


Tyr Asp Val Asp Arg Ala Ile Ser Gly Gly Ser Ile Gln Ile Glu Asn 
                245                 250                 255     


Gly Tyr Phe Val His Tyr Phe Ala Pro Glu Gly Leu Thr Thr Met Pro 
            260                 265                 270         


Lys Asn Val Val Phe Val Ile Asp Lys Ser Gly Ser Met Ser Gly Arg 
        275                 280                 285             


Lys Ile Gln Gln Thr Arg Glu Ala Leu Ile Lys Ile Leu Asp Asp Leu 
    290                 295                 300                 


Ser Pro Arg Asp Gln Phe Asn Leu Ile Val Phe Ser Thr Glu Ala Thr 
305                 310                 315                 320 


Gln Trp Arg Pro Ser Leu Val Pro Ala Ser Ala Glu Asn Val Asn Lys 
                325                 330                 335     


Ala Arg Ser Phe Ala Ala Gly Ile Gln Ala Leu Gly Gly Thr Asn Ile 
            340                 345                 350         


Asn Asp Ala Met Leu Met Ala Val Gln Leu Leu Asp Ser Ser Asn Gln 
        355                 360                 365             


Glu Glu Arg Leu Pro Glu Gly Ser Val Ser Leu Ile Ile Leu Leu Thr 
    370                 375                 380                 


Asp Gly Asp Pro Thr Val Gly Glu Thr Asn Pro Arg Ser Ile Gln Asn 
385                 390                 395                 400 


Asn Val Arg Glu Ala Val Ser Gly Arg Tyr Ser Leu Phe Cys Leu Gly 
                405                 410                 415     


Phe Gly Phe Asp Val Ser Tyr Ala Phe Leu Glu Lys Leu Ala Leu Asp 
            420                 425                 430         


Asn Gly Gly Leu Ala Arg Arg Ile His Glu Asp Ser Asp Ser Ala Leu 
        435                 440                 445             


Gln Leu Gln Asp Phe Tyr Gln Glu Val Ala Asn Pro Leu Leu Thr Ala 
    450                 455                 460                 


Val Thr Phe Glu Tyr Pro Ser Asn Ala Val Glu Glu Val Thr Gln Asn 
465                 470                 475                 480 


Asn Phe Arg Leu Leu Phe Lys Gly Ser Glu Met Val Val Ala Gly Lys 
                485                 490                 495     


Leu Gln Asp Arg Gly Pro Asp Val Leu Thr Ala Thr Val Ser Gly Lys 
            500                 505                 510         


Leu Pro Thr Gln Asn Ile Thr Phe Gln Thr Glu Ser Ser Val Ala Glu 
        515                 520                 525             


Gln Glu Ala Glu Phe Gln Ser Pro Lys Tyr Ile Phe His Asn Phe Met 
    530                 535                 540                 


Glu Arg Leu Trp Ala Tyr Leu Thr Ile Gln Gln Leu Leu Glu Gln Thr 
545                 550                 555                 560 


Val Ser Ala Ser Asp Ala Asp Gln Gln Ala Leu Arg Asn Gln Ala Leu 
                565                 570                 575     


Asn Leu Ser Leu Ala Tyr Ser Phe Val Thr Pro Leu Thr Ser Met Val 
            580                 585                 590         


Val Thr Lys Pro Asp Asp Gln Glu Gln Ser Gln Val Ala Glu Lys Pro 
        595                 600                 605             


Met Glu Gly Glu Ser Arg Asn Arg Asn Val His Ser Gly Ser Thr Phe 
    610                 615                 620                 


Phe Lys Tyr Tyr Leu Gln Gly Ala Lys Ile Pro Lys Pro Gly Leu Asp 
625                 630                 635                 640 


His Thr Glu Ala Ser Phe Ser Pro Arg Arg Gly Trp Asn Arg Gln Ala 
                645                 650                 655     


Gly Ala Ala Gly Ser Arg Met Asn Phe Arg Pro Gly Val Leu Ser Ser 
            660                 665                 670         


Arg Gln Leu Gly Leu Pro Gly Pro Pro Asp Val Pro Asp His Ala Ala 
        675                 680                 685             


Tyr His Pro Phe Arg Arg Leu Ala Ile Leu Pro Ala Ser Ala Pro Pro 
    690                 695                 700                 


Ala Thr Ser Asn Pro Asp Pro Ala Val Ser Arg Val Met Asn Met Lys 
705                 710                 715                 720 


Ile Glu Glu Thr Thr Met Thr Thr Gln Thr Pro Ala Pro Ile Gln Ala 
                725                 730                 735     


Pro Ser Ala Ile Leu Pro Leu Pro Gly Gln Ser Val Glu Arg Leu Cys 
            740                 745                 750         


Val Asp Pro Arg His Arg Gln Gly Pro Val Asn Leu Leu Ser Asp Pro 
        755                 760                 765             


Glu Gln Gly Val Glu Val Thr Gly Gln Tyr Glu Arg Glu Lys Ala Gly 
    770                 775                 780                 


Phe Ser Trp Ile Glu Val Thr Phe Lys Asn Pro Leu Val Trp Val His 
785                 790                 795                 800 


Ala Ser Pro Glu His Val Val Val Thr Arg Asn Arg Arg Ser Ser Ala 
                805                 810                 815     


Tyr Lys Trp Lys Glu Thr Leu Phe Ser Val Met Pro Gly Leu Lys Met 
            820                 825                 830         


Thr Met Asp Lys Thr Gly Leu Leu Leu Leu Ser Asp Pro Asp Lys Val 
        835                 840                 845             


Thr Ile Gly Leu Leu Phe Trp Asp Gly Arg Gly Glu Gly Leu Arg Leu 
    850                 855                 860                 


Leu Leu Arg Asp Thr Asp Arg Phe Ser Ser His Val Gly Gly Thr Leu 
865                 870                 875                 880 


Gly Gln Phe Tyr Gln Glu Val Leu Trp Gly Ser Pro Ala Ala Ser Asp 
                885                 890                 895     


Asp Gly Arg Arg Thr Leu Arg Val Gln Gly Asn Asp His Ser Ala Thr 
            900                 905                 910         


Arg Glu Arg Arg Leu Asp Tyr Gln Glu Gly Pro Pro Gly Val Glu Ile 
        915                 920                 925             


Ser Cys Trp Ser Val Glu Leu 
    930                 935 


<210>  7331
<211>  719
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7331

Xaa Val Ser Val Ala Pro Asn Ala Lys Ile Thr Phe Glu Leu Val Tyr 
1               5                   10                  15      


Glu Glu Leu Leu Lys Arg Arg Leu Gly Val Tyr Glu Leu Leu Leu Lys 
            20                  25                  30          


Val Arg Pro Gln Gln Leu Val Lys His Leu Gln Met Asp Ile His Ile 
        35                  40                  45              


Phe Glu Pro Gln Gly Ile Ser Phe Leu Glu Thr Glu Ser Thr Phe Met 
    50                  55                  60                  


Thr Asn Gln Leu Val Asp Ala Leu Thr Thr Trp Gln Asn Lys Thr Lys 
65                  70                  75                  80  


Gln Lys Ser Pro Glu Gln Gln Glu Thr Val Leu Asp Gly Asn Leu Ile 
                85                  90                  95      


Ile Arg Tyr Asp Val Asp Arg Ala Ile Ser Gly Gly Ser Ile Gln Ile 
            100                 105                 110         


Glu Asn Gly Tyr Phe Val His Tyr Phe Ala Pro Glu Gly Leu Thr Thr 
        115                 120                 125             


Met Pro Lys Asn Val Val Phe Val Ile Asp Lys Ser Gly Ser Met Ser 
    130                 135                 140                 


Gly Arg Lys Ile Gln Gln Thr Arg Glu Ala Leu Ile Lys Ile Leu Asp 
145                 150                 155                 160 


Asp Leu Ser Pro Arg Asp Gln Phe Asn Leu Ile Val Phe Ser Thr Glu 
                165                 170                 175     


Ala Thr Gln Trp Arg Pro Ser Leu Val Pro Ala Ser Ala Glu Asn Val 
            180                 185                 190         


Asn Lys Ala Arg Ser Phe Ala Ala Gly Ile Gln Ala Leu Gly Gly Thr 
        195                 200                 205             


Asn Ile Asn Asp Ala Met Leu Met Ala Val Gln Leu Leu Asp Ser Ser 
    210                 215                 220                 


Asn Gln Glu Glu Arg Leu Pro Glu Gly Ser Val Ser Leu Ile Ile Leu 
225                 230                 235                 240 


Leu Thr Asp Gly Asp Pro Thr Val Gly Glu Thr Asn Pro Arg Ser Ile 
                245                 250                 255     


Gln Asn Asn Val Arg Glu Ala Val Ser Gly Arg Tyr Ser Leu Phe Cys 
            260                 265                 270         


Leu Gly Phe Gly Phe Asp Val Ser Tyr Ala Phe Leu Glu Lys Leu Ala 
        275                 280                 285             


Leu Asp Asn Gly Gly Leu Ala Arg Arg Ile His Glu Asp Ser Asp Ser 
    290                 295                 300                 


Ala Leu Gln Leu Gln Asp Phe Tyr Gln Glu Val Ala Asn Pro Leu Leu 
305                 310                 315                 320 


Thr Ala Val Thr Phe Glu Tyr Pro Ser Asn Ala Val Glu Glu Val Thr 
                325                 330                 335     


Gln Asn Asn Phe Arg Leu Leu Phe Lys Gly Ser Glu Met Val Val Ala 
            340                 345                 350         


Gly Lys Leu Gln Asp Arg Gly Pro Asp Val Leu Thr Ala Thr Val Ser 
        355                 360                 365             


Gly Lys Leu Pro Thr Gln Asn Ile Thr Phe Gln Thr Glu Ser Ser Val 
    370                 375                 380                 


Ala Glu Gln Glu Ala Glu Phe Gln Ser Pro Lys Tyr Ile Phe His Asn 
385                 390                 395                 400 


Phe Met Glu Arg Leu Trp Ala Tyr Leu Thr Ile Gln Gln Leu Leu Glu 
                405                 410                 415     


Gln Thr Val Ser Ala Ser Asp Ala Asp Gln Gln Ala Leu Arg Asn Gln 
            420                 425                 430         


Ala Leu Asn Leu Ser Leu Ala Tyr Ser Phe Val Thr Pro Leu Thr Ser 
        435                 440                 445             


Met Val Val Thr Lys Pro Asp Asp Gln Glu Gln Ser Gln Val Ala Glu 
    450                 455                 460                 


Lys Pro Met Glu Gly Glu Ser Arg Asn Arg Asn Val His Ser Ala Gly 
465                 470                 475                 480 


Ala Ala Gly Ser Arg Met Asn Phe Arg Pro Gly Val Leu Ser Ser Arg 
                485                 490                 495     


Gln Leu Gly Leu Pro Gly Pro Pro Asp Val Pro Asp His Ala Ala Tyr 
            500                 505                 510         


His Pro Phe Arg Arg Leu Ala Ile Leu Pro Ala Ser Ala Pro Pro Ala 
        515                 520                 525             


Thr Ser Asn Pro Asp Pro Ala Val Ser Arg Val Met Asn Met Lys Ile 
    530                 535                 540                 


Glu Glu Thr Thr Met Thr Thr Gln Thr Pro Gly Val Glu Val Thr Gly 
545                 550                 555                 560 


Gln Tyr Glu Arg Glu Lys Ala Gly Phe Ser Trp Ile Glu Val Thr Phe 
                565                 570                 575     


Lys Asn Pro Leu Val Trp Val His Ala Ser Pro Glu His Val Val Val 
            580                 585                 590         


Thr Arg Asn Arg Arg Ser Ser Ala Tyr Lys Trp Lys Glu Thr Leu Phe 
        595                 600                 605             


Ser Val Met Pro Gly Leu Lys Met Thr Met Asp Lys Thr Gly Leu Leu 
    610                 615                 620                 


Leu Leu Ser Asp Pro Asp Lys Val Thr Ile Gly Leu Leu Phe Trp Asp 
625                 630                 635                 640 


Gly Arg Gly Glu Gly Leu Arg Leu Leu Leu Arg Asp Thr Asp Arg Phe 
                645                 650                 655     


Ser Ser His Val Gly Gly Thr Leu Gly Gln Phe Tyr Gln Glu Val Leu 
            660                 665                 670         


Trp Gly Ser Pro Ala Ala Ser Asp Asp Gly Arg Arg Thr Leu Arg Val 
        675                 680                 685             


Gln Gly Asn Asp His Ser Ala Thr Arg Glu Arg Arg Leu Asp Tyr Gln 
    690                 695                 700                 


Glu Gly Pro Pro Gly Val Glu Ile Ser Cys Trp Ser Val Glu Leu 
705                 710                 715                 


<210>  7332
<211>  942
<212>  PRT
<213>  Homo Sapiens

<400>  7332

Met Leu Leu Leu Leu Gly Leu Cys Leu Gly Leu Ser Leu Cys Val Gly 
1               5                   10                  15      


Ser Gln Glu Glu Ala Gln Ser Trp Gly His Ser Ser Glu Gln Asp Gly 
            20                  25                  30          


Leu Arg Val Pro Arg Gln Val Arg Leu Leu Gln Arg Leu Lys Thr Lys 
        35                  40                  45              


Pro Leu Met Thr Glu Phe Ser Val Lys Ser Thr Ile Ile Ser Arg Tyr 
    50                  55                  60                  


Ala Phe Thr Thr Val Ser Cys Arg Met Leu Asn Arg Ala Ser Glu Asp 
65                  70                  75                  80  


Gln Asp Ile Glu Phe Gln Met Gln Ile Pro Ala Ala Ala Phe Ile Thr 
                85                  90                  95      


Asn Phe Thr Met Leu Ile Gly Asp Lys Val Tyr Gln Gly Glu Ile Thr 
            100                 105                 110         


Glu Arg Glu Lys Lys Ser Gly Asp Arg Val Lys Glu Lys Arg Asn Lys 
        115                 120                 125             


Thr Thr Glu Glu Asn Gly Glu Lys Gly Thr Glu Ile Phe Arg Ala Ser 
    130                 135                 140                 


Ala Val Ile Pro Ser Lys Asp Lys Ala Ala Phe Phe Leu Ser Tyr Glu 
145                 150                 155                 160 


Glu Leu Leu Gln Arg Arg Leu Gly Lys Tyr Glu His Ser Ile Ser Val 
                165                 170                 175     


Arg Pro Gln Gln Leu Ser Gly Arg Leu Ser Val Asp Val Asn Ile Leu 
            180                 185                 190         


Glu Ser Ala Gly Ile Ala Ser Leu Glu Val Leu Pro Leu His Asn Ser 
        195                 200                 205             


Arg Gln Arg Gly Ser Gly Arg Gly Glu Asp Asp Ser Gly Pro Pro Pro 
    210                 215                 220                 


Ser Thr Val Ile Asn Gln Asn Glu Thr Phe Ala Asn Ile Ile Phe Lys 
225                 230                 235                 240 


Pro Thr Val Val Gln Gln Ala Arg Ile Ala Gln Asn Gly Ile Leu Gly 
                245                 250                 255     


Asp Phe Ile Ile Arg Tyr Asp Val Asn Arg Glu Gln Ser Ile Gly Asp 
            260                 265                 270         


Ile Gln Val Leu Asn Gly Tyr Phe Val His Tyr Phe Ala Pro Lys Asp 
        275                 280                 285             


Leu Pro Pro Leu Pro Lys Asn Val Val Phe Val Leu Asp Ser Ser Ala 
    290                 295                 300                 


Ser Met Val Gly Thr Lys Leu Arg Gln Thr Lys Asp Ala Leu Phe Thr 
305                 310                 315                 320 


Ile Leu His Asp Leu Arg Pro Gln Asp Arg Phe Ser Ile Ile Gly Phe 
                325                 330                 335     


Ser Asn Arg Ile Lys Val Trp Lys Asp His Leu Ile Ser Val Thr Pro 
            340                 345                 350         


Asp Ser Ile Arg Asp Gly Lys Val Tyr Ile His His Met Ser Pro Thr 
        355                 360                 365             


Gly Gly Thr Asp Ile Asn Gly Ala Leu Gln Arg Ala Ile Arg Leu Leu 
    370                 375                 380                 


Asn Lys Tyr Val Ala His Ser Gly Ile Gly Asp Arg Ser Val Ser Leu 
385                 390                 395                 400 


Ile Val Phe Leu Thr Asp Gly Lys Pro Thr Val Gly Glu Thr His Thr 
                405                 410                 415     


Leu Lys Ile Leu Asn Asn Thr Arg Glu Ala Ala Arg Gly Gln Val Cys 
            420                 425                 430         


Ile Phe Thr Ile Gly Ile Gly Asn Asp Val Asp Phe Arg Leu Leu Glu 
        435                 440                 445             


Lys Leu Ser Leu Glu Asn Cys Gly Leu Thr Arg Arg Val His Glu Glu 
    450                 455                 460                 


Glu Asp Ala Gly Ser Gln Leu Ile Gly Phe Tyr Asp Glu Ile Arg Thr 
465                 470                 475                 480 


Pro Leu Leu Ser Asp Ile Arg Ile Asp Tyr Pro Pro Ser Ser Val Val 
                485                 490                 495     


Gln Ala Thr Lys Thr Leu Phe Pro Asn Tyr Phe Asn Gly Ser Glu Ile 
            500                 505                 510         


Ile Ile Ala Gly Lys Leu Val Asp Arg Lys Leu Asp His Leu His Val 
        515                 520                 525             


Glu Val Thr Ala Ser Asn Ser Lys Lys Phe Ile Ile Leu Lys Thr Asp 
    530                 535                 540                 


Val Pro Val Arg Pro Gln Lys Ala Gly Lys Asp Val Thr Gly Ser Pro 
545                 550                 555                 560 


Arg Pro Gly Gly Asp Gly Glu Gly Asp Thr Asn His Ile Glu Arg Leu 
                565                 570                 575     


Trp Ser Tyr Leu Thr Thr Lys Glu Leu Leu Ser Ser Trp Leu Gln Ser 
            580                 585                 590         


Asp Asp Glu Pro Glu Lys Glu Arg Leu Arg Gln Arg Ala Gln Ala Leu 
        595                 600                 605             


Ala Val Ser Tyr Arg Phe Leu Thr Pro Phe Thr Ser Met Lys Leu Arg 
    610                 615                 620                 


Gly Pro Val Pro Arg Met Asp Gly Leu Glu Glu Ala His Gly Met Ser 
625                 630                 635                 640 


Ala Ala Met Gly Pro Glu Pro Val Val Gln Ser Val Arg Gly Ala Gly 
                645                 650                 655     


Thr Gln Pro Gly Pro Leu Leu Lys Lys Pro Tyr Gln Pro Arg Ile Lys 
            660                 665                 670         


Ile Ser Lys Thr Ser Val Asp Gly Asp Pro His Phe Val Val Asp Phe 
        675                 680                 685             


Pro Leu Ser Arg Leu Thr Val Cys Phe Asn Ile Asp Gly Gln Pro Gly 
    690                 695                 700                 


Asp Ile Leu Arg Leu Val Ser Asp His Arg Asp Ser Gly Val Thr Val 
705                 710                 715                 720 


Asn Gly Glu Leu Ile Gly Ala Pro Ala Pro Pro Asn Gly His Lys Lys 
                725                 730                 735     


Gln Arg Thr Tyr Leu Arg Thr Ile Thr Ile Leu Ile Asn Lys Pro Glu 
            740                 745                 750         


Arg Ser Tyr Leu Glu Ile Thr Pro Ser Arg Val Ile Leu Asp Gly Gly 
        755                 760                 765             


Asp Arg Leu Val Leu Pro Cys Asn Gln Ser Val Val Val Gly Ser Trp 
    770                 775                 780                 


Gly Leu Glu Val Ser Val Ser Ala Asn Ala Asn Val Thr Val Thr Ile 
785                 790                 795                 800 


Gln Gly Ser Ile Ala Phe Val Ile Leu Ile His Leu Tyr Lys Lys Pro 
                805                 810                 815     


Ala Pro Phe Gln Arg His His Leu Gly Phe Tyr Ile Ala Asn Ser Glu 
            820                 825                 830         


Gly Leu Ser Ser Asn Cys His Gly Leu Leu Gly Gln Phe Leu Asn Gln 
        835                 840                 845             


Asp Ala Arg Leu Thr Glu Asp Pro Ala Gly Pro Ser Gln Asn Leu Thr 
    850                 855                 860                 


His Pro Leu Leu Leu Gln Val Gly Glu Gly Pro Glu Ala Val Leu Thr 
865                 870                 875                 880 


Val Lys Gly His Gln Val Pro Val Val Trp Lys Gln Arg Lys Ile Tyr 
                885                 890                 895     


Asn Gly Glu Glu Gln Ile Asp Cys Trp Phe Ala Arg Asn Asn Ala Ala 
            900                 905                 910         


Lys Leu Ile Asp Gly Glu Tyr Lys Asp Tyr Leu Ala Ser His Pro Phe 
        915                 920                 925             


Asp Thr Gly Met Thr Leu Gly Arg Gly Met Ser Arg Glu Leu 
    930                 935                 940         


<210>  7333
<211>  702
<212>  PRT
<213>  Homo Sapiens

<400>  7333

Met Leu Leu Leu Leu Gly Leu Cys Leu Gly Leu Ser Leu Cys Val Gly 
1               5                   10                  15      


Ser Gln Glu Glu Ala Gln Ser Trp Gly His Ser Ser Glu Gln Asp Gly 
            20                  25                  30          


Leu Arg Val Pro Arg Gln Val Arg Leu Leu Gln Arg Leu Lys Thr Lys 
        35                  40                  45              


Pro Leu Met Thr Glu Phe Ser Val Lys Ser Thr Ile Ile Ser Arg Tyr 
    50                  55                  60                  


Ala Phe Thr Thr Val Ser Cys Arg Met Leu Asn Arg Ala Ser Glu Asp 
65                  70                  75                  80  


Gln Asp Ile Glu Phe Gln Met Gln Ile Pro Ala Ala Ala Phe Ile Thr 
                85                  90                  95      


Asn Phe Thr Met Leu Ile Gly Asp Lys Val Tyr Gln Gly Glu Ile Thr 
            100                 105                 110         


Glu Arg Glu Lys Lys Ser Gly Asp Arg Val Lys Glu Lys Arg Asn Lys 
        115                 120                 125             


Thr Thr Glu Glu Asn Gly Glu Lys Gly Thr Glu Ile Phe Arg Ala Ser 
    130                 135                 140                 


Ala Val Ile Pro Ser Lys Asp Lys Ala Ala Phe Phe Leu Ser Tyr Glu 
145                 150                 155                 160 


Glu Leu Leu Gln Arg Arg Leu Gly Lys Tyr Glu His Ser Ile Ser Val 
                165                 170                 175     


Arg Pro Gln Gln Leu Ser Gly Arg Leu Ser Val Asp Val Asn Ile Leu 
            180                 185                 190         


Glu Ser Ala Gly Ile Ala Ser Leu Glu Val Leu Pro Leu His Asn Ser 
        195                 200                 205             


Arg Gln Arg Gly Ser Gly Arg Gly Glu Asp Asp Ser Gly Pro Pro Pro 
    210                 215                 220                 


Ser Thr Val Ile Asn Gln Asn Glu Thr Phe Ala Asn Ile Ile Phe Lys 
225                 230                 235                 240 


Pro Thr Val Val Gln Gln Ala Arg Ile Ala Gln Asn Gly Ile Leu Gly 
                245                 250                 255     


Asp Phe Ile Ile Arg Tyr Asp Val Asn Arg Glu Gln Ser Ile Gly Asp 
            260                 265                 270         


Ile Gln Val Leu Asn Gly Tyr Phe Val His Tyr Phe Ala Pro Lys Asp 
        275                 280                 285             


Leu Pro Pro Leu Pro Lys Asn Val Val Phe Val Leu Asp Ser Ser Ala 
    290                 295                 300                 


Ser Met Val Gly Thr Lys Leu Arg Gln Thr Lys Asp Ala Leu Phe Thr 
305                 310                 315                 320 


Ile Leu His Asp Leu Arg Pro Gln Asp Arg Phe Ser Ile Ile Gly Phe 
                325                 330                 335     


Ser Asn Arg Ile Lys Val Trp Lys Asp His Leu Ile Ser Val Thr Pro 
            340                 345                 350         


Asp Ser Ile Arg Asp Gly Lys Val Tyr Ile His His Met Ser Pro Thr 
        355                 360                 365             


Gly Gly Thr Asp Ile Asn Gly Ala Leu Gln Arg Ala Ile Arg Leu Leu 
    370                 375                 380                 


Asn Lys Tyr Val Ala His Ser Gly Ile Gly Asp Arg Ser Val Ser Leu 
385                 390                 395                 400 


Ile Val Phe Leu Thr Asp Gly Lys Pro Thr Val Gly Glu Thr His Thr 
                405                 410                 415     


Leu Lys Ile Leu Asn Asn Thr Arg Glu Ala Ala Arg Gly Gln Val Cys 
            420                 425                 430         


Ile Phe Thr Ile Gly Ile Gly Asn Asp Val Asp Phe Arg Leu Leu Glu 
        435                 440                 445             


Lys Leu Ser Leu Glu Asn Cys Gly Leu Thr Arg Arg Val His Glu Glu 
    450                 455                 460                 


Glu Asp Ala Gly Ser Gln Leu Ile Gly Phe Tyr Asp Glu Ile Arg Thr 
465                 470                 475                 480 


Pro Leu Leu Ser Asp Ile Arg Ile Asp Tyr Pro Pro Ser Ser Val Val 
                485                 490                 495     


Gln Ala Thr Lys Thr Leu Phe Pro Asn Tyr Phe Asn Gly Ser Glu Ile 
            500                 505                 510         


Ile Ile Ala Gly Lys Leu Val Asp Arg Lys Leu Asp His Leu His Val 
        515                 520                 525             


Glu Val Thr Ala Ser Asn Ser Lys Lys Phe Ile Ile Leu Lys Thr Asp 
    530                 535                 540                 


Val Pro Val Arg Pro Gln Lys Ala Gly Lys Asp Val Thr Gly Ser Pro 
545                 550                 555                 560 


Arg Pro Gly Gly Asp Gly Glu Gly Asp Thr Asn His Ile Glu Arg Leu 
                565                 570                 575     


Trp Ser Tyr Leu Thr Thr Lys Glu Leu Leu Ser Ser Trp Leu Gln Ser 
            580                 585                 590         


Asp Asp Glu Pro Glu Lys Glu Arg Leu Arg Gln Arg Ala Gln Ala Leu 
        595                 600                 605             


Ala Val Ser Tyr Arg Phe Leu Thr Pro Phe Thr Ser Met Lys Leu Arg 
    610                 615                 620                 


Gly Pro Val Pro Arg Met Asp Gly Leu Glu Glu Ala His Gly Met Ser 
625                 630                 635                 640 


Ala Ala Met Gly Pro Glu Pro Val Val Gln Ser Val Arg Gly Ala Gly 
                645                 650                 655     


Thr Gln Pro Gly Pro Leu Leu Lys Lys Pro Tyr Gln Pro Arg Ile Lys 
            660                 665                 670         


Ile Ser Lys Thr Ser Val Arg Gly Phe Arg Arg Glu Glu Gln Ile Phe 
        675                 680                 685             


Ser Asn Val Met Lys Phe Pro Phe Ala Ser Ile Leu Glu Leu 
    690                 695                 700         


<210>  7334
<211>  728
<212>  PRT
<213>  Homo Sapiens

<400>  7334

Met Arg Asn Tyr Asp Ser Gly Pro Pro Pro Ser Thr Val Ile Asn Gln 
1               5                   10                  15      


Asn Glu Thr Phe Ala Asn Ile Ile Phe Lys Pro Thr Val Val Gln Gln 
            20                  25                  30          


Ala Arg Ile Ala Gln Asn Gly Ile Leu Gly Asp Phe Ile Ile Arg Tyr 
        35                  40                  45              


Asp Val Asn Arg Glu Gln Ser Ile Gly Asp Ile Gln Val Leu Asn Gly 
    50                  55                  60                  


Tyr Phe Val His Tyr Phe Ala Pro Lys Asp Leu Pro Pro Leu Pro Lys 
65                  70                  75                  80  


Asn Val Val Phe Val Leu Asp Ser Ser Ala Ser Met Val Gly Thr Lys 
                85                  90                  95      


Leu Arg Gln Thr Lys Asp Ala Leu Phe Thr Ile Leu His Asp Leu Arg 
            100                 105                 110         


Pro Gln Asp Arg Phe Ser Ile Ile Gly Phe Ser Asn Arg Ile Lys Val 
        115                 120                 125             


Trp Lys Asp His Leu Ile Ser Val Thr Pro Asp Ser Ile Arg Asp Gly 
    130                 135                 140                 


Lys Val Tyr Ile His His Met Ser Pro Thr Gly Gly Thr Asp Ile Asn 
145                 150                 155                 160 


Gly Ala Leu Gln Arg Ala Ile Arg Leu Leu Asn Lys Tyr Val Ala His 
                165                 170                 175     


Ser Gly Ile Gly Asp Arg Ser Val Ser Leu Ile Val Phe Leu Thr Asp 
            180                 185                 190         


Gly Lys Pro Thr Val Gly Glu Thr His Thr Leu Lys Ile Leu Asn Asn 
        195                 200                 205             


Thr Arg Glu Ala Ala Arg Gly Gln Val Cys Ile Phe Thr Ile Gly Ile 
    210                 215                 220                 


Gly Asn Asp Val Asp Phe Arg Leu Leu Glu Lys Leu Ser Leu Glu Asn 
225                 230                 235                 240 


Cys Gly Leu Thr Arg Arg Val His Glu Glu Glu Asp Ala Gly Ser Gln 
                245                 250                 255     


Leu Ile Gly Phe Tyr Asp Glu Ile Arg Thr Pro Leu Leu Ser Asp Ile 
            260                 265                 270         


Arg Ile Asp Tyr Pro Pro Ser Ser Val Val Gln Ala Thr Lys Thr Leu 
        275                 280                 285             


Phe Pro Asn Tyr Phe Asn Gly Ser Glu Ile Ile Ile Ala Gly Lys Leu 
    290                 295                 300                 


Val Asp Arg Lys Leu Asp His Leu His Val Glu Val Thr Ala Ser Asn 
305                 310                 315                 320 


Ser Lys Lys Phe Ile Ile Leu Lys Thr Asp Val Pro Val Arg Pro Gln 
                325                 330                 335     


Lys Ala Gly Lys Asp Val Thr Gly Ser Pro Arg Pro Gly Gly Asp Gly 
            340                 345                 350         


Glu Gly Asp Thr Asn His Ile Glu Arg Leu Trp Ser Tyr Leu Thr Thr 
        355                 360                 365             


Lys Glu Leu Leu Ser Ser Trp Leu Gln Ser Asp Asp Glu Pro Glu Lys 
    370                 375                 380                 


Glu Arg Leu Arg Gln Arg Ala Gln Ala Leu Ala Val Ser Tyr Arg Phe 
385                 390                 395                 400 


Leu Thr Pro Phe Thr Ser Met Lys Leu Arg Gly Pro Val Pro Arg Met 
                405                 410                 415     


Asp Gly Leu Glu Glu Ala His Gly Met Ser Ala Ala Met Gly Pro Glu 
            420                 425                 430         


Pro Val Val Gln Ser Val Arg Gly Ala Gly Thr Gln Pro Gly Pro Leu 
        435                 440                 445             


Leu Lys Lys Pro Tyr Gln Pro Arg Ile Lys Ile Ser Lys Thr Ser Val 
    450                 455                 460                 


Asp Gly Asp Pro His Phe Val Val Asp Phe Pro Leu Ser Arg Leu Thr 
465                 470                 475                 480 


Val Cys Phe Asn Ile Asp Gly Gln Pro Gly Asp Ile Leu Arg Leu Val 
                485                 490                 495     


Ser Asp His Arg Asp Ser Gly Val Thr Val Asn Gly Glu Leu Ile Gly 
            500                 505                 510         


Ala Pro Ala Pro Pro Asn Gly His Lys Lys Gln Arg Thr Tyr Leu Arg 
        515                 520                 525             


Thr Ile Thr Ile Leu Ile Asn Lys Pro Glu Arg Ser Tyr Leu Glu Ile 
    530                 535                 540                 


Thr Pro Ser Arg Val Ile Leu Asp Gly Gly Asp Arg Leu Val Leu Pro 
545                 550                 555                 560 


Cys Asn Gln Ser Val Val Val Gly Ser Trp Gly Leu Glu Val Ser Val 
                565                 570                 575     


Ser Ala Asn Ala Asn Val Thr Val Thr Ile Gln Gly Ser Ile Ala Phe 
            580                 585                 590         


Val Ile Leu Ile His Leu Tyr Lys Lys Pro Ala Pro Phe Gln Arg His 
        595                 600                 605             


His Leu Gly Phe Tyr Ile Ala Asn Ser Glu Gly Leu Ser Ser Asn Cys 
    610                 615                 620                 


His Gly Leu Leu Gly Gln Phe Leu Asn Gln Asp Ala Arg Leu Thr Glu 
625                 630                 635                 640 


Asp Pro Ala Gly Pro Ser Gln Asn Leu Thr His Pro Leu Leu Leu Gln 
                645                 650                 655     


Val Gly Glu Gly Pro Glu Ala Val Leu Thr Val Lys Gly His Gln Val 
            660                 665                 670         


Pro Val Val Trp Lys Gln Arg Lys Ile Tyr Asn Gly Glu Glu Gln Ile 
        675                 680                 685             


Asp Cys Trp Phe Ala Arg Asn Asn Ala Ala Lys Leu Ile Asp Gly Glu 
    690                 695                 700                 


Tyr Lys Asp Tyr Leu Ala Ser His Pro Phe Asp Thr Gly Met Thr Leu 
705                 710                 715                 720 


Gly Arg Gly Met Ser Arg Glu Leu 
                725             


<210>  7335
<211>  119
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7335

Xaa Pro Ser Thr Val Ile Asn Gln Asn Glu Thr Phe Ala Asn Ile Ile 
1               5                   10                  15      


Phe Lys Pro Thr Val Val Gln Gln Ala Arg Ile Ala Gln Asn Gly Ile 
            20                  25                  30          


Leu Gly Asp Phe Ile Ile Arg Tyr Asp Val Asn Arg Glu Gln Ser Ile 
        35                  40                  45              


Gly Asp Ile Gln Val Leu Asn Gly Tyr Phe Val His Tyr Phe Ala Pro 
    50                  55                  60                  


Lys Asp Leu Pro Pro Leu Pro Lys Asn Val Val Phe Val Leu Asp Ser 
65                  70                  75                  80  


Ser Ala Ser Met Val Gly Thr Lys Leu Arg Gln Asp Ile Gly Phe Ser 
                85                  90                  95      


Leu Ala Val Gln Asn Trp Val Pro Lys Gly Tyr Leu Asp Ile Ser Cys 
            100                 105                 110         


Val Thr Leu Gln Val His Val 
        115                 


<210>  7336
<211>  1313
<212>  PRT
<213>  Homo Sapiens

<400>  7336

Met Ser Gly Trp Arg Tyr Leu Ile Cys Val Ser Phe Leu Leu Thr Ile 
1               5                   10                  15      


Leu Leu Glu Leu Thr Tyr Gln Gly Pro Pro Val Pro Ala Ser Ser Ser 
            20                  25                  30          


Thr Lys Leu Leu Met Thr Ser Tyr Ser Met Arg Ser Thr Val Val Ser 
        35                  40                  45              


Arg Tyr Ala His Thr Leu Val Thr Ser Val Leu Phe Asn Pro His Ala 
    50                  55                  60                  


Glu Ala His Glu Ala Ile Phe Asp Leu Asp Leu Pro His Leu Ala Phe 
65                  70                  75                  80  


Ile Ser Asn Phe Thr Met Thr Ile Asn Asn Lys Val Tyr Ile Ala Glu 
                85                  90                  95      


Val Lys Glu Lys His Gln Ala Lys Lys Ile Tyr Glu Glu Ala His Gln 
            100                 105                 110         


Gln Gly Lys Thr Ala Ala His Val Gly Ile Arg Asp Arg Glu Ser Glu 
        115                 120                 125             


Lys Phe Arg Ile Ser Thr Ser Leu Ala Ala Gly Thr Glu Val Thr Phe 
    130                 135                 140                 


Ser Leu Ala Tyr Glu Glu Leu Leu Gln Arg His Gln Gly Gln Tyr Gln 
145                 150                 155                 160 


Leu Val Val Ser Leu Arg Pro Gly Gln Leu Val Lys Arg Leu Ser Ile 
                165                 170                 175     


Glu Val Thr Val Ser Glu Arg Thr Gly Ile Ser Tyr Val His Ile Pro 
            180                 185                 190         


Pro Leu Arg Thr Gly Arg Leu Arg Thr Asn Ala His Ala Ser Glu Val 
        195                 200                 205             


Asp Ser Pro Pro Ser Thr Arg Ile Glu Arg Gly Glu Thr Cys Val Arg 
    210                 215                 220                 


Ile Thr Tyr Cys Pro Thr Leu Gln Asp Gln Ser Ser Ile Ser Gly Ser 
225                 230                 235                 240 


Gly Ile Met Ala Asp Phe Leu Val Gln Tyr Asp Val Val Met Glu Asp 
                245                 250                 255     


Ile Ile Gly Asp Val Gln Ile Tyr Asp Asp Tyr Phe Ile His Tyr Phe 
            260                 265                 270         


Ala Pro Arg Gly Leu Pro Pro Met Glu Lys Asn Val Val Phe Val Ile 
        275                 280                 285             


Asp Val Ser Ser Ser Met Phe Gly Thr Lys Met Glu Gln Thr Lys Thr 
    290                 295                 300                 


Ala Met Asn Val Ile Leu Ser Asp Leu Gln Ala Asn Asp Tyr Phe Asn 
305                 310                 315                 320 


Ile Ile Ser Phe Ser Asp Thr Val Asn Val Trp Lys Ala Gly Gly Ser 
                325                 330                 335     


Ile Gln Ala Thr Ile Gln Asn Val His Ser Ala Lys Asp Tyr Leu His 
            340                 345                 350         


Cys Met Glu Ala Asp Gly Trp Thr Asp Val Asn Ser Ala Leu Leu Ala 
        355                 360                 365             


Ala Ala Ser Val Leu Asn His Ser Asn Gln Glu Pro Gly Arg Gly Pro 
    370                 375                 380                 


Ser Val Gly Arg Ile Pro Leu Ile Ile Phe Leu Thr Asp Gly Glu Pro 
385                 390                 395                 400 


Thr Ala Gly Val Thr Thr Pro Ser Val Ile Leu Ser Asn Val Arg Gln 
                405                 410                 415     


Ala Leu Gly His Arg Val Ser Leu Phe Ser Leu Ala Phe Gly Asp Asp 
            420                 425                 430         


Ala Asp Phe Thr Leu Leu Arg Arg Leu Ser Leu Glu Asn Arg Gly Ile 
        435                 440                 445             


Ala Arg Arg Ile Tyr Glu Asp Thr Asp Ala Ala Leu Gln Leu Lys Gly 
    450                 455                 460                 


Leu Tyr Glu Glu Ile Ser Met Pro Leu Leu Ala Asp Val Arg Leu Asn 
465                 470                 475                 480 


Tyr Leu Gly Gly Leu Val Gly Ala Ser Pro Trp Ala Val Phe Pro Asn 
                485                 490                 495     


Tyr Phe Gly Gly Ser Glu Leu Val Val Ala Gly Gln Val Gln Pro Gly 
            500                 505                 510         


Lys Gln Glu Leu Gly Ile His Leu Ala Ala Arg Gly Pro Lys Asp Gln 
        515                 520                 525             


Leu Leu Val Ala His His Ser Glu Gly Ala Thr Asn Asn Ser Gln Lys 
    530                 535                 540                 


Ala Phe Gly Cys Pro Gly Glu Pro Ala Pro Asn Val Ala His Phe Ile 
545                 550                 555                 560 


Arg Arg Leu Trp Ala Tyr Val Thr Ile Gly Glu Leu Leu Asp Ala His 
                565                 570                 575     


Phe Gln Ala Arg Asp Thr Thr Thr Arg His Leu Leu Ala Ala Lys Val 
            580                 585                 590         


Leu Asn Leu Ser Leu Glu Tyr Asn Phe Val Thr Pro Leu Thr Ser Leu 
        595                 600                 605             


Val Met Val Gln Pro Lys Gln Ala Ser Glu Glu Thr Arg Arg Gln Thr 
    610                 615                 620                 


Ser Thr Ser Ala Gly Pro Asp Thr Ile Met Pro Ser Ser Ser Ser Arg 
625                 630                 635                 640 


His Gly Leu Gly Val Ser Thr Ala Gln Pro Ala Leu Val Pro Lys Val 
                645                 650                 655     


Ile Ser Pro Lys Ser Arg Pro Val Lys Pro Lys Phe Tyr Leu Ser Ser 
            660                 665                 670         


Thr Thr Thr Ala Ser Thr Lys Lys Met Leu Ser Ser Lys Glu Leu Glu 
        675                 680                 685             


Pro Leu Gly Glu Ser Pro His Thr Leu Ser Met Pro Thr Tyr Pro Lys 
    690                 695                 700                 


Ala Lys Ile Pro Ala Gln Gln Asp Ser Gly Thr Leu Ala Gln Pro Thr 
705                 710                 715                 720 


Leu Arg Thr Lys Pro Thr Ile Leu Val Pro Ser Asn Ser Gly Thr Leu 
                725                 730                 735     


Leu Pro Leu Lys Pro Gly Ser Leu Ser His Gln Asn Pro Asp Ile Leu 
            740                 745                 750         


Pro Thr Asn Ser Arg Thr Gln Val Pro Pro Val Lys Pro Gly Ile Pro 
        755                 760                 765             


Ala Ser Pro Lys Ala Asp Thr Val Lys Cys Val Thr Pro Leu His Ser 
    770                 775                 780                 


Lys Pro Gly Ala Pro Ser His Pro Gln Leu Gly Ala Leu Thr Ser Gln 
785                 790                 795                 800 


Ala Pro Lys Gly Leu Pro Gln Ser Arg Pro Gly Val Ser Thr Leu Gln 
                805                 810                 815     


Val Pro Lys Tyr Pro Leu His Thr Arg Pro Arg Val Pro Ala Pro Lys 
            820                 825                 830         


Thr Arg Asn Asn Met Pro His Leu Gly Pro Gly Ile Leu Leu Ser Lys 
        835                 840                 845             


Thr Pro Lys Ile Leu Leu Ser Leu Lys Pro Ser Ala Pro Pro His Gln 
    850                 855                 860                 


Ile Ser Thr Ser Ile Ser Leu Ser Lys Pro Glu Thr Pro Asn Pro His 
865                 870                 875                 880 


Met Pro Gln Thr Pro Leu Pro Pro Arg Pro Asp Arg Pro Arg Pro Pro 
                885                 890                 895     


Leu Pro Glu Ser Leu Ser Thr Phe Pro Asn Thr Ile Ser Ser Ser Thr 
            900                 905                 910         


Gly Pro Ser Ser Thr Thr Thr Thr Ser Val Leu Gly Glu Pro Leu Pro 
        915                 920                 925             


Met Pro Phe Thr Pro Thr Leu Pro Pro Gly Arg Phe Trp His Gln Tyr 
    930                 935                 940                 


Asp Leu Leu Pro Gly Pro Gln Arg Thr Arg Gln Val Leu Gly Pro Ser 
945                 950                 955                 960 


Arg Pro Gly Val Pro Thr Met Ser Leu Leu Asn Ser Ser Arg Pro Thr 
                965                 970                 975     


Pro Glu Gly Ser Pro Pro Asn Leu Pro Ile Leu Leu Pro Ser Ser Ile 
            980                 985                 990         


Leu Pro Glu Ala Ile Ser Leu Leu  Leu Leu Pro Glu Glu  Leu Glu Leu 
        995                 1000                 1005             


Leu Ser  Glu Ser Met Val Glu  Ser Lys Phe Val Glu  Ser Leu Asn 
    1010                 1015                 1020             


Pro Pro  Ala Phe Tyr Thr Phe  Leu Thr Pro Asp Glu  Asp Gly Ser 
    1025                 1030                 1035             


Pro Asn  Trp Asp Gly Asn Ser  Glu Glu Ile Leu Gly  Gly Ala Gly 
    1040                 1045                 1050             


Gly Ser  Met Glu Ser Gln Gly  Ser Ser Val Gly Leu  Ala Lys Gly 
    1055                 1060                 1065             


Thr Leu  Pro Ser Ile Phe Thr  Phe Ser Ser Ser Val  Asp Gly Asp 
    1070                 1075                 1080             


Pro His  Phe Val Ile Gln Ile  Pro His Ser Glu Glu  Lys Ile Cys 
    1085                 1090                 1095             


Phe Thr  Leu Asn Gly His Pro  Gly Asp Leu Leu Gln  Leu Ile Glu 
    1100                 1105                 1110             


Asp Pro  Lys Ala Gly Leu His  Val Ser Gly Lys Leu  Leu Gly Ala 
    1115                 1120                 1125             


Pro Pro  Arg Pro Gly His Lys  Asp Gln Thr Arg Thr  Tyr Phe Gln 
    1130                 1135                 1140             


Ile Ile  Thr Val Thr Thr Asp  Lys Pro Arg Ala Tyr  Thr Ile Thr 
    1145                 1150                 1155             


Ile Ser  Arg Ser Ser Ile Ser  Leu Arg Gly Glu Gly  Thr Leu Arg 
    1160                 1165                 1170             


Leu Ser  Trp Asp Gln Pro Ala  Leu Leu Lys Arg Pro  Gln Leu Glu 
    1175                 1180                 1185             


Leu Tyr  Val Ala Ala Ala Ala  Arg Leu Thr Leu Arg  Leu Gly Pro 
    1190                 1195                 1200             


Tyr Leu  Glu Phe Leu Val Leu  Arg His Arg Tyr Arg  His Pro Ser 
    1205                 1210                 1215             


Thr Leu  Gln Leu Pro His Leu  Gly Phe Tyr Val Ala  Asn Gly Ser 
    1220                 1225                 1230             


Gly Leu  Ser Pro Ser Ala Arg  Gly Leu Ile Gly Gln  Phe Gln His 
    1235                 1240                 1245             


Ala Asp  Ile Arg Leu Val Thr  Gly Pro Met Gly Pro  Cys Leu Arg 
    1250                 1255                 1260             


Arg His  His Gly Pro Asp Val  Pro Val Ile Leu Gly  Lys Arg Leu 
    1265                 1270                 1275             


Leu Lys  Asp Ser Pro Arg Leu  Leu Pro Arg Trp Ala  Ser Cys Trp 
    1280                 1285                 1290             


Leu Val  Lys Arg Ser His Val  Glu Leu Leu Leu Gly  His Pro Tyr 
    1295                 1300                 1305             


Leu Ser  Tyr Val Leu 
    1310             


<210>  7337
<211>  313
<212>  PRT
<213>  Homo Sapiens

<400>  7337

Met Asn Gln Leu Ser Phe Leu Leu Phe Leu Ile Ala Thr Thr Arg Gly 
1               5                   10                  15      


Trp Ser Thr Asp Glu Ala Asn Thr Tyr Phe Lys Glu Trp Thr Cys Ser 
            20                  25                  30          


Ser Ser Pro Ser Leu Pro Arg Ser Cys Lys Glu Ile Lys Asp Glu Cys 
        35                  40                  45              


Pro Ser Ala Phe Asp Gly Leu Tyr Phe Leu Arg Thr Glu Asn Gly Val 
    50                  55                  60                  


Ile Tyr Gln Thr Phe Cys Asp Met Thr Ser Gly Gly Gly Gly Trp Thr 
65                  70                  75                  80  


Leu Val Ala Ser Val His Glu Asn Asp Met Arg Gly Lys Cys Thr Val 
                85                  90                  95      


Gly Asp Arg Trp Ser Ser Gln Gln Gly Ser Lys Ala Val Tyr Pro Glu 
            100                 105                 110         


Gly Asp Gly Asn Trp Ala Asn Tyr Asn Thr Phe Gly Ser Ala Glu Ala 
        115                 120                 125             


Ala Thr Ser Asp Asp Tyr Lys Asn Pro Gly Tyr Tyr Asp Ile Gln Ala 
    130                 135                 140                 


Lys Asp Leu Gly Ile Trp His Val Pro Asn Lys Ser Pro Met Gln His 
145                 150                 155                 160 


Trp Arg Asn Ser Ser Leu Leu Arg Tyr Arg Thr Asp Thr Gly Phe Leu 
                165                 170                 175     


Gln Thr Leu Gly His Asn Leu Phe Gly Ile Tyr Gln Lys Tyr Pro Val 
            180                 185                 190         


Lys Tyr Gly Glu Gly Lys Cys Trp Thr Asp Asn Gly Pro Val Ile Pro 
        195                 200                 205             


Val Val Tyr Asp Phe Gly Asp Ala Gln Lys Thr Ala Ser Tyr Tyr Ser 
    210                 215                 220                 


Pro Tyr Gly Gln Arg Glu Phe Thr Ala Gly Phe Val Gln Phe Arg Val 
225                 230                 235                 240 


Phe Asn Asn Glu Arg Ala Ala Asn Ala Leu Cys Ala Gly Met Arg Val 
                245                 250                 255     


Thr Gly Cys Asn Thr Glu His His Cys Ile Gly Gly Gly Gly Tyr Phe 
            260                 265                 270         


Pro Glu Ala Ser Pro Gln Gln Cys Gly Asp Phe Ser Gly Phe Asp Trp 
        275                 280                 285             


Ser Gly Tyr Gly Thr His Val Gly Tyr Ser Ser Ser Arg Glu Ile Thr 
    290                 295                 300                 


Glu Ala Ala Val Leu Leu Phe Tyr Arg 
305                 310             


<210>  7338
<211>  325
<212>  PRT
<213>  Homo Sapiens

<400>  7338

Met Leu Ser Met Leu Arg Thr Met Thr Arg Leu Cys Phe Leu Leu Phe 
1               5                   10                  15      


Phe Ser Val Ala Thr Ser Gly Cys Ser Ala Ala Ala Ala Ser Ser Leu 
            20                  25                  30          


Glu Met Leu Ser Arg Glu Phe Glu Thr Cys Ala Phe Ser Phe Ser Ser 
        35                  40                  45              


Leu Pro Arg Ser Cys Lys Glu Ile Lys Glu Arg Cys His Ser Ala Gly 
    50                  55                  60                  


Asp Gly Leu Tyr Phe Leu Arg Thr Lys Asn Gly Val Val Tyr Gln Thr 
65                  70                  75                  80  


Phe Cys Asp Met Thr Ser Gly Gly Gly Gly Trp Thr Leu Val Ala Ser 
                85                  90                  95      


Val His Glu Asn Asp Met Arg Gly Lys Cys Thr Val Gly Asp Arg Trp 
            100                 105                 110         


Ser Ser Gln Gln Gly Asn Lys Ala Asp Tyr Pro Glu Gly Asp Gly Asn 
        115                 120                 125             


Trp Ala Asn Tyr Asn Thr Phe Gly Ser Ala Glu Ala Ala Thr Ser Asp 
    130                 135                 140                 


Asp Tyr Lys Asn Pro Gly Tyr Tyr Asp Ile Gln Ala Lys Asp Leu Gly 
145                 150                 155                 160 


Ile Trp His Val Pro Asn Lys Ser Pro Met Gln His Trp Arg Asn Ser 
                165                 170                 175     


Ala Leu Leu Arg Tyr Arg Thr Asn Thr Gly Phe Leu Gln Arg Leu Gly 
            180                 185                 190         


His Asn Leu Phe Gly Ile Tyr Gln Lys Tyr Pro Val Lys Tyr Arg Ser 
        195                 200                 205             


Gly Lys Cys Trp Asn Asp Asn Gly Pro Ala Ile Pro Val Val Tyr Asp 
    210                 215                 220                 


Phe Gly Asp Ala Lys Lys Thr Ala Ser Tyr Tyr Ser Pro Tyr Gly Gln 
225                 230                 235                 240 


Arg Glu Phe Val Ala Gly Phe Val Gln Phe Arg Val Phe Asn Asn Glu 
                245                 250                 255     


Arg Ala Ala Asn Ala Leu Cys Ala Gly Ile Lys Val Thr Gly Cys Asn 
            260                 265                 270         


Thr Glu His His Cys Ile Gly Gly Gly Gly Phe Phe Pro Gln Gly Lys 
        275                 280                 285             


Pro Arg Gln Cys Gly Asp Phe Ser Ala Phe Asp Trp Asp Gly Tyr Gly 
    290                 295                 300                 


Thr His Val Lys Ser Ser Cys Ser Arg Glu Ile Thr Glu Ala Ala Val 
305                 310                 315                 320 


Leu Leu Phe Tyr Arg 
                325 


<210>  7339
<211>  243
<212>  PRT
<213>  Homo Sapiens

<400>  7339

Met Ala Cys Trp Trp Pro Leu Leu Leu Glu Leu Trp Thr Val Met Pro 
1               5                   10                  15      


Thr Trp Ala Gly Asp Glu Leu Leu Asn Ile Cys Met Asn Ala Lys His 
            20                  25                  30          


His Lys Arg Val Pro Ser Pro Glu Asp Lys Leu Tyr Glu Glu Cys Ile 
        35                  40                  45              


Pro Trp Lys Asp Asn Ala Cys Cys Thr Leu Thr Thr Ser Trp Glu Ala 
    50                  55                  60                  


His Leu Asp Val Ser Pro Leu Tyr Asn Phe Ser Leu Phe His Cys Gly 
65                  70                  75                  80  


Leu Leu Met Pro Gly Cys Arg Lys His Phe Ile Gln Ala Ile Cys Phe 
                85                  90                  95      


Tyr Glu Cys Ser Pro Asn Leu Gly Pro Trp Ile Gln Pro Val Ala Pro 
            100                 105                 110         


Ser Gly Gln Gly Glu Arg Val Val Asn Val Pro Leu Cys Gln Glu Asp 
        115                 120                 125             


Cys Glu Glu Trp Trp Glu Asp Cys Arg Met Ser Tyr Thr Cys Lys Ser 
    130                 135                 140                 


Asn Trp Arg Gly Gly Trp Asp Trp Ser Gln Gly Lys Asn Arg Cys Pro 
145                 150                 155                 160 


Lys Gly Ala Gln Cys Leu Pro Phe Ser His Tyr Phe Pro Thr Pro Ala 
                165                 170                 175     


Asp Leu Cys Glu Lys Thr Trp Ser Asn Ser Phe Lys Ala Ser Pro Glu 
            180                 185                 190         


Arg Arg Asn Ser Gly Arg Cys Leu Gln Lys Trp Phe Glu Pro Ala Gln 
        195                 200                 205             


Gly Asn Pro Asn Val Ala Val Ala Arg Leu Phe Ala Ser Ser Ala Pro 
    210                 215                 220                 


Ser Trp Glu Leu Ser Tyr Thr Ile Met Val Cys Ser Leu Phe Leu Pro 
225                 230                 235                 240 


Phe Leu Ser 
            


<210>  7340
<211>  250
<212>  PRT
<213>  Homo Sapiens

<400>  7340

Met Ala Cys Trp Trp Pro Leu Leu Leu Glu Leu Trp Thr Val Met Pro 
1               5                   10                  15      


Thr Trp Ala Gly Asp Glu Leu Leu Asn Ile Cys Met Asn Ala Lys His 
            20                  25                  30          


His Lys Arg Val Pro Ser Pro Glu Asp Lys Leu Tyr Glu Glu Cys Ile 
        35                  40                  45              


Pro Trp Lys Asp Asn Ala Cys Cys Thr Leu Thr Thr Ser Trp Glu Ala 
    50                  55                  60                  


His Leu Asp Val Ser Pro Leu Tyr Asn Phe Ser Leu Phe His Cys Gly 
65                  70                  75                  80  


Leu Leu Met Pro Gly Cys Arg Lys His Phe Ile Gln Ala Ile Cys Phe 
                85                  90                  95      


Tyr Glu Cys Ser Pro Asn Leu Gly Pro Trp Ile Gln Pro Val Gly Ser 
            100                 105                 110         


Leu Gly Trp Glu Val Ala Pro Ser Gly Gln Gly Glu Arg Val Val Asn 
        115                 120                 125             


Val Pro Leu Cys Gln Glu Asp Cys Glu Glu Trp Trp Glu Asp Cys Arg 
    130                 135                 140                 


Met Ser Tyr Thr Cys Lys Ser Asn Trp Arg Gly Gly Trp Asp Trp Ser 
145                 150                 155                 160 


Gln Gly Lys Asn Arg Cys Pro Lys Gly Ala Gln Cys Leu Pro Phe Ser 
                165                 170                 175     


His Tyr Phe Pro Thr Pro Ala Asp Leu Cys Glu Lys Thr Trp Ser Asn 
            180                 185                 190         


Ser Phe Lys Ala Ser Pro Glu Arg Arg Asn Ser Gly Arg Cys Leu Gln 
        195                 200                 205             


Lys Trp Phe Glu Pro Ala Gln Gly Asn Pro Asn Val Ala Val Ala Arg 
    210                 215                 220                 


Leu Phe Ala Ser Ser Ala Pro Ser Trp Glu Leu Ser Tyr Thr Ile Met 
225                 230                 235                 240 


Val Cys Ser Leu Phe Leu Pro Phe Leu Ser 
                245                 250 


<210>  7341
<211>  184
<212>  PRT
<213>  Homo Sapiens

<400>  7341

Met Ala Leu Leu Leu Cys Leu Val Cys Leu Thr Ala Ala Leu Ala His 
1               5                   10                  15      


Gly Cys Leu His Cys His Ser Asn Phe Ser Lys Lys Phe Ser Phe Tyr 
            20                  25                  30          


Arg His His Val Asn Phe Lys Ser Trp Trp Val Gly Asp Ile Pro Val 
        35                  40                  45              


Ser Gly Ala Leu Leu Thr Asp Trp Ser Asp Asp Thr Met Lys Glu Leu 
    50                  55                  60                  


His Leu Ala Ile Pro Ala Lys Ile Thr Arg Glu Lys Leu Asp Gln Val 
65                  70                  75                  80  


Ala Thr Ala Val Tyr Gln Met Met Asp Gln Leu Tyr Gln Gly Lys Met 
                85                  90                  95      


Tyr Phe Pro Gly Lys Gly Arg Glu Thr Glu Ala Gly Pro Pro His Pro 
            100                 105                 110         


Gly Thr Pro Arg Pro Pro Pro Glu Pro Asp Leu Leu Leu Pro Arg Arg 
        115                 120                 125             


Leu Arg Val Phe Pro Gln Arg Ala Ala Lys His Leu Pro Gly Ala Gly 
    130                 135                 140                 


Ala Pro His Pro Glu Arg His His Arg Lys Pro His Arg Leu Ser Ala 
145                 150                 155                 160 


Pro Leu Trp Ser Ser Ala Gln Trp Lys Ser Ala Val Gln Gly Leu Leu 
                165                 170                 175     


Asn Tyr Ile Asn Asn Trp His Lys 
            180                 


<210>  7342
<211>  232
<212>  PRT
<213>  Homo Sapiens

<400>  7342

Met Ala Leu Leu Leu Cys Leu Val Cys Leu Thr Ala Ala Leu Ala His 
1               5                   10                  15      


Gly Cys Leu His Cys His Ser Asn Phe Ser Lys Lys Phe Ser Phe Tyr 
            20                  25                  30          


Arg His His Val Asn Phe Lys Ser Trp Trp Val Gly Asp Ile Pro Val 
        35                  40                  45              


Ser Gly Ala Leu Leu Thr Asp Trp Ser Asp Asp Thr Met Lys Glu Leu 
    50                  55                  60                  


His Leu Ala Ile Pro Ala Lys Ile Thr Arg Glu Lys Leu Asp Gln Val 
65                  70                  75                  80  


Ala Thr Ala Val Tyr Gln Met Met Asp Gln Leu Tyr Gln Gly Lys Met 
                85                  90                  95      


Tyr Phe Pro Gly Tyr Phe Pro Asn Glu Leu Arg Asn Ile Phe Arg Glu 
            100                 105                 110         


Gln Val His Leu Ile Gln Asn Ala Ile Ile Glu Ser Arg Ile Asp Cys 
        115                 120                 125             


Gln His Arg Cys Gly Ile Phe Gln Tyr Glu Thr Ile Ser Cys Asn Asn 
    130                 135                 140                 


Cys Thr Asp Ser His Val Ala Cys Phe Gly Tyr Asn Cys Glu Ser Ser 
145                 150                 155                 160 


Ala Gln Trp Lys Ser Ala Val Gln Gly Leu Leu Asn Tyr Ile Asn Asn 
                165                 170                 175     


Trp His Lys Gln Asp Thr Ser Met Arg Pro Arg Ser Ser Ala Phe Ser 
            180                 185                 190         


Trp Pro Gly Thr His Arg Ala Thr Pro Ala Phe Leu Val Ser Pro Ala 
        195                 200                 205             


Leu Arg Cys Leu Glu Pro Pro His Leu Ala Asn Leu Thr Leu Glu Asp 
    210                 215                 220                 


Ala Ala Glu Cys Leu Lys Gln His 
225                 230         


<210>  7343
<211>  214
<212>  PRT
<213>  Homo Sapiens

<400>  7343

Met Ala Leu Leu Leu Cys Leu Val Cys Leu Thr Ala Ala Leu Ala His 
1               5                   10                  15      


Gly Cys Leu His Cys His Ser Asn Phe Ser Lys Lys Phe Ser Phe Tyr 
            20                  25                  30          


Arg His His Val Asn Phe Lys Ser Trp Trp Val Gly Asp Ile Pro Val 
        35                  40                  45              


Ser Gly Ala Leu Leu Thr Asp Trp Ser Asp Asp Thr Met Lys Glu Leu 
    50                  55                  60                  


His Leu Ala Ile Pro Ala Lys Ile Thr Arg Glu Lys Leu Asp Gln Val 
65                  70                  75                  80  


Ala Thr Ala Val Tyr Gln Met Met Asp Gln Leu Tyr Gln Gly Lys Met 
                85                  90                  95      


Tyr Phe Pro Gly Tyr Phe Pro Asn Glu Leu Arg Asn Ile Phe Arg Glu 
            100                 105                 110         


Gln Val His Leu Ile Gln Asn Ala Ile Ile Glu Ser Arg Ile Asp Cys 
        115                 120                 125             


Gln His Arg Cys Gly Ile Phe Gln Tyr Glu Thr Ile Ser Cys Asn Asn 
    130                 135                 140                 


Cys Thr Asp Ser His Val Ala Cys Phe Gly Tyr Asn Cys Glu Ser Ser 
145                 150                 155                 160 


Ala Gln Trp Lys Ser Ala Val Gln Gly Leu Leu Asn Tyr Ile Asn Asn 
                165                 170                 175     


Trp His Lys Gln Asp Thr Ser Met Ser Leu Val Ser Pro Ala Leu Arg 
            180                 185                 190         


Cys Leu Glu Pro Pro His Leu Ala Asn Leu Thr Leu Glu Asp Ala Ala 
        195                 200                 205             


Glu Cys Leu Lys Gln His 
    210                 


<210>  7344
<211>  208
<212>  PRT
<213>  Homo Sapiens

<400>  7344

Met Ala Leu Leu Leu Cys Leu Val Cys Leu Thr Ala Ala Leu Ala His 
1               5                   10                  15      


Gly Cys Leu His Cys His Ser Asn Phe Ser Lys Lys Phe Ser Phe Tyr 
            20                  25                  30          


Arg His His Val Asn Phe Lys Ser Trp Trp Val Gly Asp Ile Pro Val 
        35                  40                  45              


Ser Gly Ala Leu Leu Thr Asp Trp Ser Asp Asp Thr Met Lys Glu Leu 
    50                  55                  60                  


His Leu Ala Ile Pro Ala Lys Ile Thr Arg Glu Lys Leu Asp Gln Val 
65                  70                  75                  80  


Ala Thr Ala Val Tyr Gln Met Met Asp Gln Leu Tyr Gln Gly Lys Met 
                85                  90                  95      


Tyr Phe Pro Gly Tyr Phe Pro Asn Glu Leu Arg Asn Ile Phe Arg Glu 
            100                 105                 110         


Gln Val His Leu Ile Gln Asn Ala Ile Ile Glu Ser Arg Ile Asp Cys 
        115                 120                 125             


Gln His Arg Cys Gly Ile Phe Gln Tyr Glu Thr Ile Ser Cys Asn Asn 
    130                 135                 140                 


Cys Thr Asp Ser His Val Ala Cys Phe Gly Tyr Asn Cys Glu Ser Ser 
145                 150                 155                 160 


Ala Gln Trp Lys Ser Ala Val Gln Gly Leu Leu Asn Tyr Ile Asn Asn 
                165                 170                 175     


Trp His Asn Leu Val Ser Pro Ala Leu Arg Cys Leu Glu Pro Pro His 
            180                 185                 190         


Leu Ala Asn Leu Thr Leu Glu Asp Ala Ala Glu Cys Leu Lys Gln His 
        195                 200                 205             


<210>  7345
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  7345

Val Ser Gly Ala Leu Leu Thr Asp Trp Ser Asp Asp Thr Met Lys Glu 
1               5                   10                  15      


Leu His Leu Ala Ile Pro Ala Lys Ile Thr Arg Glu Lys Leu Asp Gln 
            20                  25                  30          


Val Ala Thr Ala Val Tyr Gln Met Met Asp Gln Leu Tyr Gln Gly Lys 
        35                  40                  45              


Met Tyr Phe Pro Gly Tyr Phe Pro Asn Glu Leu Arg Asn Ile Phe Arg 
    50                  55                  60                  


Glu Gln Val His Leu Ile Gln Asn Ala Ile Ile Glu Ser Ile Phe Gln 
65                  70                  75                  80  


Tyr Glu Thr Ile Ser Cys Asn Asn Cys Thr Asp Ser His Val Ala Cys 
                85                  90                  95      


Phe Gly Tyr Asn Cys Glu Ser Ser Ala Gln Trp Lys Ser Ala Val Gln 
            100                 105                 110         


Gly Leu Leu Asn Tyr Ile Asn Asn Trp His Asn Leu Val Ser Pro Ala 
        115                 120                 125             


Leu Arg Cys Leu Glu Pro Pro His Leu Ala Asn Leu Thr Leu Glu Asp 
    130                 135                 140                 


Ala Ala Glu Cys Leu Lys Gln His 
145                 150         


<210>  7346
<211>  152
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7346

Xaa Pro Gln Gln Leu Leu Gln Glu Val Leu Leu Leu Pro Pro Pro Cys 
1               5                   10                  15      


Glu Leu Gln Val Leu Val Gly Gly Arg His Pro Arg Val Arg Gly Ala 
            20                  25                  30          


Ala His Arg Leu Glu Arg Arg His Asp Glu Gly Ala Ala Pro Gly His 
        35                  40                  45              


Pro Arg Gln Asp His Pro Gly Glu Ala Gly Pro Ser Gly Asp Ser Ser 
    50                  55                  60                  


Val Pro Asp Asp Gly Ser Ala Val Pro Gly Glu Asp Val Leu Pro Arg 
65                  70                  75                  80  


Val Phe Pro Gln Arg Ala Ala Lys His Leu Pro Gly Ala Gly Ala Pro 
                85                  90                  95      


His Pro Glu Arg His His Arg Lys Pro His Arg Leu Ser Ala Pro Leu 
            100                 105                 110         


Trp Ser Ser Ala Gln Trp Lys Ser Ala Val Gln Gly Leu Leu Asn Tyr 
        115                 120                 125             


Ile Asn Asn Trp His Lys Pro Arg Ser Ser Ala Phe Ser Trp Pro Gly 
    130                 135                 140                 


Thr His Arg Ala Thr Pro Ala Leu 
145                 150         


<210>  7347
<211>  138
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7347

Xaa Ser Ala Leu Pro Gln Gln Leu Leu Gln Glu Val Leu Leu Leu Pro 
1               5                   10                  15      


Pro Pro Cys Glu Leu Gln Val Leu Val Gly Gly Arg His Pro Arg Val 
            20                  25                  30          


Arg Gly Ala Ala His Arg Leu Glu Arg Arg His Asp Glu Gly Ala Ala 
        35                  40                  45              


Pro Gly His Pro Arg Gln Asp His Pro Gly Glu Ala Gly Pro Ser Gly 
    50                  55                  60                  


Asp Ser Ser Val Pro Asp Asp Gly Ser Ala Val Pro Gly Glu Asp Val 
65                  70                  75                  80  


Leu Pro Arg Val Phe Pro Gln Arg Ala Ala Lys His Leu Pro Gly Ala 
                85                  90                  95      


Gly Ala Pro His Pro Glu Arg His His Arg Lys Pro His Arg Leu Ser 
            100                 105                 110         


Ala Pro Leu Trp His Leu Pro Val Arg Asp His Leu Leu Gln Gln Leu 
        115                 120                 125             


His Arg Leu Ala Arg Arg Leu Leu Trp Leu 
    130                 135             


<210>  7348
<211>  155
<212>  PRT
<213>  Homo Sapiens

<400>  7348

Met Phe Cys Pro Leu Lys Leu Ile Leu Leu Pro Val Leu Leu Asp Tyr 
1               5                   10                  15      


Ser Leu Gly Leu Asn Asp Leu Asn Val Ser Pro Pro Glu Leu Thr Val 
            20                  25                  30          


His Val Gly Asp Ser Ala Leu Met Gly Cys Val Phe Gln Ser Thr Glu 
        35                  40                  45              


Asp Lys Cys Ile Phe Lys Ile Asp Trp Thr Leu Ser Pro Gly Glu His 
    50                  55                  60                  


Ala Lys Asp Glu Tyr Val Leu Tyr Tyr Tyr Ser Asn Leu Ser Val Pro 
65                  70                  75                  80  


Ile Gly Arg Phe Gln Asn Arg Val His Leu Met Gly Asp Ile Leu Cys 
                85                  90                  95      


Asn Asp Gly Ser Leu Leu Leu Gln Asp Val Gln Glu Ala Asp Gln Gly 
            100                 105                 110         


Thr Tyr Ile Cys Glu Ile Arg Leu Lys Gly Glu Ser Gln Val Phe Lys 
        115                 120                 125             


Lys Ala Val Val Leu His Val Leu Pro Glu Glu Pro Lys Glu Leu Met 
    130                 135                 140                 


Val His Val Gly Gly Leu Ile Gln Met Gly Cys 
145                 150                 155 


<210>  7349
<211>  383
<212>  PRT
<213>  Homo Sapiens

<400>  7349

Met Phe Cys Pro Leu Lys Leu Ile Leu Leu Pro Val Leu Leu Asp Tyr 
1               5                   10                  15      


Ser Leu Gly Leu Asn Asp Leu Asn Val Ser Pro Pro Glu Leu Thr Val 
            20                  25                  30          


His Val Gly Asp Ser Ala Leu Met Gly Cys Val Phe Gln Ser Thr Glu 
        35                  40                  45              


Asp Lys Cys Ile Phe Lys Ile Asp Trp Thr Leu Ser Pro Gly Glu His 
    50                  55                  60                  


Ala Lys Asp Glu Tyr Val Leu Tyr Tyr Tyr Ser Asn Leu Ser Val Pro 
65                  70                  75                  80  


Ile Gly Arg Phe Gln Asn Arg Val His Leu Met Gly Asp Ile Leu Cys 
                85                  90                  95      


Asn Asp Gly Ser Leu Leu Leu Gln Asp Val Gln Glu Ala Asp Gln Gly 
            100                 105                 110         


Thr Tyr Ile Cys Glu Ile Arg Leu Lys Gly Glu Ser Gln Val Phe Lys 
        115                 120                 125             


Lys Ala Val Val Leu His Val Leu Pro Glu Glu Pro Lys Glu Leu Met 
    130                 135                 140                 


Val His Val Gly Gly Leu Ile Gln Met Gly Cys Val Phe Gln Ser Thr 
145                 150                 155                 160 


Glu Val Lys His Val Thr Lys Glu Glu Ile Val Phe Arg Tyr Tyr His 
                165                 170                 175     


Lys Leu Arg Met Ser Val Glu Tyr Ser Gln Ser Trp Gly His Phe Gln 
            180                 185                 190         


Asn Arg Val Asn Leu Val Gly Asp Ile Phe Arg Asn Asp Gly Ser Ile 
        195                 200                 205             


Met Leu Gln Gly Val Arg Glu Ser Asp Gly Gly Asn Tyr Thr Cys Ser 
    210                 215                 220                 


Ile His Leu Gly Asn Leu Val Phe Lys Lys Thr Ile Val Leu His Val 
225                 230                 235                 240 


Ser Pro Glu Glu Pro Arg Thr Leu Val Thr Pro Ala Ala Leu Arg Pro 
                245                 250                 255     


Leu Val Leu Gly Gly Asn Gln Leu Val Ile Ile Val Gly Ile Val Cys 
            260                 265                 270         


Ala Thr Ile Leu Leu Leu Pro Val Leu Ile Leu Ile Val Lys Lys Thr 
        275                 280                 285             


Cys Gly Asn Lys Ser Ser Val Asn Ser Thr Val Leu Val Lys Asn Thr 
    290                 295                 300                 


Lys Lys Thr Asn Pro Glu Ile Lys Glu Lys Pro Cys His Phe Glu Arg 
305                 310                 315                 320 


Cys Glu Gly Glu Lys His Ile Tyr Ser Pro Ile Ile Val Arg Glu Val 
                325                 330                 335     


Ile Glu Glu Glu Glu Pro Ser Glu Lys Ser Glu Ala Thr Tyr Met Thr 
            340                 345                 350         


Met His Pro Val Trp Pro Ser Leu Arg Ser Asp Arg Asn Asn Ser Leu 
        355                 360                 365             


Glu Lys Lys Ser Gly Gly Gly Met Pro Lys Thr Gln Gln Ala Phe 
    370                 375                 380             


<210>  7350
<211>  394
<212>  PRT
<213>  Homo Sapiens

<400>  7350

Met Phe Cys Pro Leu Lys Leu Ile Leu Leu Pro Val Leu Leu Asp Tyr 
1               5                   10                  15      


Ser Leu Gly Leu Asn Asp Leu Asn Val Ser Pro Pro Glu Leu Thr Val 
            20                  25                  30          


His Val Gly Asp Ser Ala Leu Met Gly Cys Val Phe Gln Ser Thr Glu 
        35                  40                  45              


Asp Lys Cys Ile Phe Lys Ile Asp Trp Thr Leu Ser Pro Gly Glu His 
    50                  55                  60                  


Ala Lys Asp Glu Tyr Val Leu Tyr Tyr Tyr Ser Asn Leu Ser Val Pro 
65                  70                  75                  80  


Ile Gly Arg Phe Gln Asn Arg Val His Leu Met Gly Asp Ile Leu Cys 
                85                  90                  95      


Asn Asp Gly Ser Leu Leu Leu Gln Asp Val Gln Glu Ala Asp Gln Gly 
            100                 105                 110         


Thr Tyr Ile Cys Glu Ile Arg Leu Lys Gly Glu Ser Gln Val Phe Lys 
        115                 120                 125             


Lys Ala Val Val Leu His Val Leu Pro Glu Glu Pro Lys Glu Leu Met 
    130                 135                 140                 


Val His Val Gly Gly Leu Ile Gln Met Gly Cys Val Phe Gln Ser Thr 
145                 150                 155                 160 


Glu Val Lys His Val Thr Lys Val Glu Trp Ile Phe Ser Gly Arg Arg 
                165                 170                 175     


Ala Lys Glu Glu Ile Val Phe Arg Tyr Tyr His Lys Leu Arg Met Ser 
            180                 185                 190         


Val Glu Tyr Ser Gln Ser Trp Gly His Phe Gln Asn Arg Val Asn Leu 
        195                 200                 205             


Val Gly Asp Ile Phe Arg Asn Asp Gly Ser Ile Met Leu Gln Gly Val 
    210                 215                 220                 


Arg Glu Ser Asp Gly Gly Asn Tyr Thr Cys Ser Ile His Leu Gly Asn 
225                 230                 235                 240 


Leu Val Phe Lys Lys Thr Ile Val Leu His Val Ser Pro Glu Glu Pro 
                245                 250                 255     


Arg Thr Leu Val Thr Pro Ala Ala Leu Arg Pro Leu Val Leu Gly Gly 
            260                 265                 270         


Asn Gln Leu Val Ile Ile Val Gly Ile Val Cys Ala Thr Ile Leu Leu 
        275                 280                 285             


Leu Pro Val Leu Ile Leu Ile Val Lys Lys Thr Cys Gly Asn Lys Ser 
    290                 295                 300                 


Ser Val Asn Ser Thr Val Leu Val Lys Asn Thr Lys Lys Thr Asn Pro 
305                 310                 315                 320 


Glu Ile Lys Glu Lys Pro Cys His Phe Glu Arg Cys Glu Gly Glu Lys 
                325                 330                 335     


His Ile Tyr Ser Pro Ile Ile Val Arg Glu Val Ile Glu Glu Glu Glu 
            340                 345                 350         


Pro Ser Glu Lys Ser Glu Ala Thr Tyr Met Thr Met His Pro Val Trp 
        355                 360                 365             


Pro Ser Leu Arg Ser Asp Arg Asn Asn Ser Leu Glu Lys Lys Ser Gly 
    370                 375                 380                 


Gly Gly Met Pro Lys Thr Gln Gln Ala Phe 
385                 390                 


<210>  7351
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  7351

Met Phe Cys Pro Leu Lys Leu Ile Leu Leu Pro Val Leu Leu Glu His 
1               5                   10                  15      


Arg Arg Gln Met Tyr Ile Gln Asp Arg Leu Asp Ser Val Thr Arg Arg 
            20                  25                  30          


Ala Arg Gln Gly Arg Ile Cys Ala Ile Leu Leu Leu Gln Ser Gln Cys 
        35                  40                  45              


Ala Tyr Trp Ala Leu Pro Glu Pro Arg Thr Leu Asp Gly Gly His Leu 
    50                  55                  60                  


Met Gln 
65      


<210>  7352
<211>  121
<212>  PRT
<213>  Homo Sapiens

<400>  7352

Met Gly Cys Val Phe Gln Ser Thr Glu Asp Lys Cys Ile Phe Lys Ile 
1               5                   10                  15      


Asp Trp Thr Leu Ser Pro Gly Glu His Ala Lys Asp Glu Tyr Val Leu 
            20                  25                  30          


Tyr Tyr Tyr Ser Asn Leu Ser Val Pro Ile Gly Arg Phe Gln Asn Arg 
        35                  40                  45              


Val His Leu Met Gly Asp Ile Leu Cys Asn Asp Gly Ser Leu Leu Leu 
    50                  55                  60                  


Gln Asp Val Gln Glu Ala Asp Gln Gly Thr Tyr Ile Cys Glu Ile Arg 
65                  70                  75                  80  


Leu Lys Gly Glu Ser Gln Val Phe Lys Lys Ala Val Val Leu His Val 
                85                  90                  95      


Leu Pro Glu Glu Pro Lys Glu Leu Met Val His Val Gly Gly Leu Ile 
            100                 105                 110         


Gln Met Gly Cys Val Phe Gln Ser Thr 
        115                 120     


<210>  7353
<211>  220
<212>  PRT
<213>  Homo Sapiens

<400>  7353

Met Gly Cys Val Phe Gln Ser Thr Glu Asp Lys Cys Ile Phe Lys Ile 
1               5                   10                  15      


Asp Trp Thr Leu Ser Pro Gly Glu His Ala Lys Asp Glu Tyr Val Leu 
            20                  25                  30          


Tyr Tyr Tyr Ser Asn Leu Ser Val Pro Ile Gly Arg Phe Gln Asn Arg 
        35                  40                  45              


Val His Leu Met Gly Asp Ile Leu Cys Asn Asp Gly Ser Leu Leu Leu 
    50                  55                  60                  


Gln Asp Val Gln Glu Ala Asp Gln Gly Thr Tyr Ile Cys Glu Ile Arg 
65                  70                  75                  80  


Leu Lys Gly Glu Ser Gln Val Phe Lys Lys Ala Val Val Leu His Val 
                85                  90                  95      


Leu Pro Glu Glu Pro Lys Glu Leu Met Val His Val Gly Gly Leu Ile 
            100                 105                 110         


Gln Met Gly Cys Val Phe Gln Ser Thr Glu Val Lys His Val Thr Lys 
        115                 120                 125             


Val Glu Trp Ile Phe Ser Gly Arg Arg Ala Lys Glu Glu Ile Val Phe 
    130                 135                 140                 


Arg Tyr Tyr His Lys Leu Arg Met Ser Val Glu Tyr Ser Gln Ser Trp 
145                 150                 155                 160 


Gly His Phe Gln Asn Arg Val Asn Leu Val Gly Asp Ile Phe Arg Asn 
                165                 170                 175     


Asp Gly Ser Ile Met Leu Gln Gly Val Arg Glu Ser Asp Gly Gly Asn 
            180                 185                 190         


Tyr Thr Cys Ser Ile His Leu Gly Asn Leu Val Phe Lys Lys Thr Ile 
        195                 200                 205             


Val Leu His Val Ser Pro Glu Glu Pro Arg Lys Trp 
    210                 215                 220 


<210>  7354
<211>  305
<212>  PRT
<213>  Homo Sapiens

<400>  7354

Met Gly Cys Val Phe Gln Ser Thr Glu Asp Lys Cys Ile Phe Lys Ile 
1               5                   10                  15      


Asp Trp Thr Leu Ser Pro Gly Glu His Ala Lys Asp Glu Tyr Val Leu 
            20                  25                  30          


Tyr Tyr Tyr Ser Asn Leu Ser Val Pro Ile Gly Arg Phe Gln Asn Arg 
        35                  40                  45              


Val His Leu Met Gly Asp Ile Leu Cys Asn Asp Gly Ser Leu Leu Leu 
    50                  55                  60                  


Gln Asp Val Gln Glu Ala Asp Gln Gly Thr Tyr Ile Cys Glu Ile Arg 
65                  70                  75                  80  


Leu Lys Gly Glu Ser Gln Val Phe Lys Lys Ala Val Val Leu His Val 
                85                  90                  95      


Leu Pro Glu Glu Pro Lys Glu Leu Met Val His Val Gly Gly Leu Ile 
            100                 105                 110         


Gln Met Gly Cys Val Phe Gln Ser Thr Glu Val Lys His Val Thr Lys 
        115                 120                 125             


Val Glu Trp Ile Phe Ser Gly Arg Arg Ala Lys Glu Glu Ile Val Phe 
    130                 135                 140                 


Arg Tyr Tyr His Lys Leu Arg Met Ser Val Glu Tyr Ser Gln Ser Trp 
145                 150                 155                 160 


Gly His Phe Gln Asn Arg Val Asn Leu Val Gly Asp Ile Phe Arg Asn 
                165                 170                 175     


Asp Gly Ser Ile Met Leu Gln Gly Val Arg Glu Ser Asp Gly Gly Asn 
            180                 185                 190         


Tyr Thr Cys Ser Ile His Leu Gly Asn Leu Val Phe Lys Lys Thr Ile 
        195                 200                 205             


Val Leu His Val Ser Pro Glu Glu Pro Arg Thr Leu Val Thr Pro Ala 
    210                 215                 220                 


Ala Leu Arg Pro Leu Val Leu Gly Gly Asn Gln Leu Val Ile Ile Val 
225                 230                 235                 240 


Gly Ile Val Cys Ala Thr Ile Leu Leu Leu Pro Val Leu Ile Leu Ile 
                245                 250                 255     


Val Lys Lys Thr Cys Gly Asn Lys Ser Ser Val Asn Ser Thr Val Leu 
            260                 265                 270         


Val Lys Asn Thr Lys Lys Thr Asn Pro Glu Ile Lys Glu Lys Pro Cys 
        275                 280                 285             


His Phe Glu Arg Cys Glu Gly Glu Val Asn Thr Arg Phe Ser Leu Lys 
    290                 295                 300                 


His 
305 


<210>  7355
<211>  355
<212>  PRT
<213>  Homo Sapiens

<400>  7355

Met Gly Cys Val Phe Gln Ser Thr Glu Asp Lys Cys Ile Phe Lys Ile 
1               5                   10                  15      


Asp Trp Thr Leu Ser Pro Gly Glu His Ala Lys Asp Glu Tyr Val Leu 
            20                  25                  30          


Tyr Tyr Tyr Ser Asn Leu Ser Val Pro Ile Gly Arg Phe Gln Asn Arg 
        35                  40                  45              


Val His Leu Met Gly Asp Ile Leu Cys Asn Asp Gly Ser Leu Leu Leu 
    50                  55                  60                  


Gln Asp Val Gln Glu Ala Asp Gln Gly Thr Tyr Ile Cys Glu Ile Arg 
65                  70                  75                  80  


Leu Lys Gly Glu Ser Gln Val Phe Lys Lys Ala Val Val Leu His Val 
                85                  90                  95      


Leu Pro Glu Glu Pro Lys Glu Leu Met Val His Val Gly Gly Leu Ile 
            100                 105                 110         


Gln Met Gly Cys Val Phe Gln Ser Thr Glu Val Lys His Val Thr Lys 
        115                 120                 125             


Val Glu Trp Ile Phe Ser Gly Arg Arg Ala Lys Glu Glu Ile Val Phe 
    130                 135                 140                 


Arg Tyr Tyr His Lys Leu Arg Met Ser Val Glu Tyr Ser Gln Ser Trp 
145                 150                 155                 160 


Gly His Phe Gln Asn Arg Val Asn Leu Val Gly Asp Ile Phe Arg Asn 
                165                 170                 175     


Asp Gly Ser Ile Met Leu Gln Gly Val Arg Glu Ser Asp Gly Gly Asn 
            180                 185                 190         


Tyr Thr Cys Ser Ile His Leu Gly Asn Leu Val Phe Lys Lys Thr Ile 
        195                 200                 205             


Val Leu His Val Ser Pro Glu Glu Pro Arg Thr Leu Val Thr Pro Ala 
    210                 215                 220                 


Ala Leu Arg Pro Leu Val Leu Gly Gly Asn Gln Leu Val Ile Ile Val 
225                 230                 235                 240 


Gly Ile Val Cys Ala Thr Ile Leu Leu Leu Pro Val Leu Ile Leu Ile 
                245                 250                 255     


Val Lys Lys Thr Cys Gly Asn Lys Ser Ser Val Asn Ser Thr Val Leu 
            260                 265                 270         


Val Lys Asn Thr Lys Lys Thr Asn Pro Glu Ile Lys Glu Lys Pro Cys 
        275                 280                 285             


His Phe Glu Arg Cys Glu Gly Glu Lys His Ile Tyr Ser Pro Ile Ile 
    290                 295                 300                 


Val Arg Glu Val Ile Glu Glu Glu Glu Pro Ser Glu Lys Ser Glu Ala 
305                 310                 315                 320 


Thr Tyr Met Thr Met His Pro Val Trp Pro Ser Leu Arg Ser Asp Arg 
                325                 330                 335     


Asn Asn Ser Leu Glu Lys Lys Ser Gly Gly Gly Met Pro Lys Thr Gln 
            340                 345                 350         


Gln Ala Phe 
        355 


<210>  7356
<211>  384
<212>  PRT
<213>  Homo Sapiens

<400>  7356

Met Val Ser Gly Asp Tyr Ser Leu Gly Leu Asn Asp Leu Asn Val Ser 
1               5                   10                  15      


Pro Pro Glu Leu Thr Val His Val Gly Asp Ser Ala Leu Met Gly Cys 
            20                  25                  30          


Val Phe Gln Ser Thr Glu Asp Lys Cys Ile Phe Lys Ile Asp Trp Thr 
        35                  40                  45              


Leu Ser Pro Gly Glu His Ala Lys Asp Glu Tyr Val Leu Tyr Tyr Tyr 
    50                  55                  60                  


Ser Asn Leu Ser Val Pro Ile Gly Arg Phe Gln Asn Arg Val His Leu 
65                  70                  75                  80  


Met Gly Asp Ile Leu Cys Asn Asp Gly Ser Leu Leu Leu Gln Asp Val 
                85                  90                  95      


Gln Glu Ala Asp Gln Gly Thr Tyr Ile Cys Glu Ile Arg Leu Lys Gly 
            100                 105                 110         


Glu Ser Gln Val Phe Lys Lys Ala Val Val Leu His Val Leu Pro Glu 
        115                 120                 125             


Glu Pro Lys Glu Leu Met Val His Val Gly Gly Leu Ile Gln Met Gly 
    130                 135                 140                 


Cys Val Phe Gln Ser Thr Glu Val Lys His Val Thr Lys Val Glu Trp 
145                 150                 155                 160 


Ile Phe Ser Gly Arg Arg Ala Lys Glu Glu Ile Val Phe Arg Tyr Tyr 
                165                 170                 175     


His Lys Leu Arg Met Ser Val Glu Tyr Ser Gln Ser Trp Gly His Phe 
            180                 185                 190         


Gln Asn Arg Val Asn Leu Val Gly Asp Ile Phe Arg Asn Asp Gly Ser 
        195                 200                 205             


Ile Met Leu Gln Gly Val Arg Glu Ser Asp Gly Gly Asn Tyr Thr Cys 
    210                 215                 220                 


Ser Ile His Leu Gly Asn Leu Val Phe Lys Lys Thr Ile Val Leu His 
225                 230                 235                 240 


Val Ser Pro Glu Glu Pro Arg Thr Leu Val Thr Pro Ala Ala Leu Arg 
                245                 250                 255     


Pro Leu Val Leu Gly Gly Asn Gln Leu Val Ile Ile Val Gly Ile Val 
            260                 265                 270         


Cys Ala Thr Ile Leu Leu Leu Pro Val Leu Ile Leu Ile Val Lys Lys 
        275                 280                 285             


Thr Cys Gly Asn Lys Ser Ser Val Asn Ser Thr Val Leu Val Lys Asn 
    290                 295                 300                 


Thr Lys Lys Thr Asn Pro Glu Ile Lys Glu Lys Pro Cys His Phe Glu 
305                 310                 315                 320 


Arg Cys Glu Gly Glu Lys His Ile Tyr Ser Pro Ile Ile Val Arg Glu 
                325                 330                 335     


Val Ile Glu Glu Glu Glu Pro Ser Glu Lys Ser Glu Ala Thr Tyr Met 
            340                 345                 350         


Thr Met His Pro Val Trp Pro Ser Leu Arg Ser Asp Arg Asn Asn Ser 
        355                 360                 365             


Leu Glu Lys Lys Ser Gly Gly Gly Met Pro Lys Thr Gln Gln Ala Phe 
    370                 375                 380                 


<210>  7357
<211>  70
<212>  PRT
<213>  Homo Sapiens

<400>  7357

Met Lys Asn His Leu Leu Phe Trp Gly Val Leu Ala Val Phe Ile Lys 
1               5                   10                  15      


Ala Val His Val Lys Ala Gln Glu Asp Glu Arg Ile Val Leu Val Asp 
            20                  25                  30          


Asn Lys Cys Lys Cys Ala Arg Ile Thr Ser Arg Ile Ile Arg Ser Ser 
        35                  40                  45              


Glu Asp Pro Asn Glu Asp Ile Val Glu Arg Asn Ile Arg Ile Ile Val 
    50                  55                  60                  


Pro Leu Asn Asn Arg Glu 
65                  70  


<210>  7358
<211>  159
<212>  PRT
<213>  Homo Sapiens

<400>  7358

Met Lys Asn His Leu Leu Phe Trp Gly Val Leu Ala Val Phe Ile Lys 
1               5                   10                  15      


Ala Val His Val Lys Ala Gln Glu Asp Glu Arg Ile Val Leu Val Asp 
            20                  25                  30          


Asn Lys Cys Lys Cys Ala Arg Ile Thr Ser Arg Ile Ile Arg Ser Ser 
        35                  40                  45              


Glu Asp Pro Asn Glu Asp Ile Val Glu Arg Asn Ile Arg Ile Ile Val 
    50                  55                  60                  


Pro Leu Asn Asn Arg Glu Asn Ile Ser Asp Pro Thr Ser Pro Leu Arg 
65                  70                  75                  80  


Thr Arg Phe Val Tyr His Leu Ser Asp Leu Cys Lys Lys Cys Asp Pro 
                85                  90                  95      


Thr Glu Val Glu Leu Asp Asn Gln Ile Val Thr Ala Thr Gln Ser Asn 
            100                 105                 110         


Ile Cys Asp Glu Asp Ser Ala Thr Glu Thr Cys Tyr Thr Tyr Asp Arg 
        115                 120                 125             


Asn Lys Cys Tyr Thr Ala Val Val Pro Leu Val Tyr Gly Gly Glu Thr 
    130                 135                 140                 


Lys Met Val Glu Thr Ala Leu Thr Pro Asp Ala Cys Tyr Pro Asp 
145                 150                 155                 


<210>  7359
<211>  159
<212>  PRT
<213>  Homo Sapiens

<400>  7359

Met Lys Asn His Leu Leu Phe Trp Gly Val Leu Ala Val Phe Ile Lys 
1               5                   10                  15      


Ala Val His Val Lys Ala Gln Glu Asp Glu Arg Ile Val Leu Val Asp 
            20                  25                  30          


Asn Lys Cys Lys Cys Ala Arg Ile Thr Ser Arg Ile Ile Arg Ser Ser 
        35                  40                  45              


Glu Asp Pro Asn Glu Asp Ile Val Glu Arg Asn Ile Arg Ile Ile Val 
    50                  55                  60                  


Pro Leu Asn Asn Arg Glu Asn Ile Ser Asp Pro Thr Ser Pro Leu Arg 
65                  70                  75                  80  


Thr Arg Phe Val Tyr His Leu Ser Asp Leu Cys Lys Lys Cys Asp Pro 
                85                  90                  95      


Thr Glu Val Glu Leu Asp Asn Gln Ile Val Thr Ala Thr Gln Ser Asn 
            100                 105                 110         


Ile Cys Asp Glu Asp Ser Ala Thr Glu Thr Cys Tyr Thr Tyr Asp Arg 
        115                 120                 125             


Asn Lys Cys Tyr Thr Ala Val Val Pro Leu Val Tyr Gly Gly Glu Thr 
    130                 135                 140                 


Lys Met Val Glu Thr Ala Leu Thr Pro Asp Ala Cys Tyr Pro Asp 
145                 150                 155                 


<210>  7360
<211>  159
<212>  PRT
<213>  Homo Sapiens

<400>  7360

Met Lys Asn His Leu Leu Phe Trp Gly Val Leu Ala Val Phe Ile Lys 
1               5                   10                  15      


Ala Val His Val Lys Ala Gln Glu Asp Glu Arg Ile Val Leu Val Asp 
            20                  25                  30          


Asn Lys Cys Lys Cys Ala Arg Ile Thr Ser Arg Ile Ile Arg Ser Ser 
        35                  40                  45              


Glu Asp Pro Asn Glu Asp Ile Val Glu Arg Asn Ile Arg Ile Ile Val 
    50                  55                  60                  


Pro Leu Asn Asn Arg Glu Asn Ile Ser Asp Pro Thr Ser Pro Leu Arg 
65                  70                  75                  80  


Thr Arg Phe Val Tyr His Leu Ser Asp Leu Cys Lys Lys Cys Asp Pro 
                85                  90                  95      


Thr Glu Val Glu Leu Asp Asn Gln Ile Val Thr Ala Thr Gln Ser Asn 
            100                 105                 110         


Ile Cys Asp Glu Asp Ser Ala Thr Glu Thr Cys Tyr Thr Tyr Asp Arg 
        115                 120                 125             


Asn Lys Cys Tyr Thr Ala Val Val Pro Leu Val Tyr Gly Gly Glu Thr 
    130                 135                 140                 


Lys Met Val Glu Thr Ala Leu Thr Pro Asp Ala Cys Tyr Pro Asp 
145                 150                 155                 


<210>  7361
<211>  158
<212>  PRT
<213>  Homo Sapiens

<400>  7361

Met Lys Asn His Leu Leu Phe Trp Gly Val Leu Ala Val Phe Ile Lys 
1               5                   10                  15      


Ala Val His Val Lys Glu Asn Gly Ile His Ser Glu Phe Arg Ala Gln 
            20                  25                  30          


Glu Asp Glu Arg Ile Val Leu Val Asp Asn Lys Cys Lys Cys Ala Arg 
        35                  40                  45              


Ile Thr Ser Arg Ile Ile Arg Ser Ser Glu Asp Pro Asn Glu Asp Ile 
    50                  55                  60                  


Val Glu Arg Asn Ile Arg Ile Ile Val Pro Leu Asn Asn Arg Glu Asn 
65                  70                  75                  80  


Ile Ser Asp Pro Thr Ser Pro Leu Arg Thr Arg Phe Val Tyr His Leu 
                85                  90                  95      


Ser Asp Leu Cys Lys Lys Cys Asp Pro Thr Glu Val Glu Leu Asp Asn 
            100                 105                 110         


Gln Ile Val Thr Ala Thr Gln Ser Asn Ile Cys Asp Glu Asp Ser Ala 
        115                 120                 125             


Thr Glu Thr Cys Tyr Thr Tyr Asp Arg Asn Lys Cys Tyr Thr Ala Val 
    130                 135                 140                 


Val Pro Leu Val Tyr Gly Gly Glu Thr Lys Met Val Glu Thr 
145                 150                 155             


<210>  7362
<211>  157
<212>  PRT
<213>  Homo Sapiens

<400>  7362

Met Lys Asn His Leu Leu Phe Trp Gly Val Leu Ala Val Phe Ile Lys 
1               5                   10                  15      


Ala Val His Val Lys Gly Ser Arg Asp Ser Ser Ala Ser Ala Ser Arg 
            20                  25                  30          


Val Ala Gly Ile Thr Ala Gln Glu Asp Glu Arg Ile Val Leu Val Asp 
        35                  40                  45              


Asn Lys Cys Lys Cys Ala Arg Ile Thr Ser Arg Ile Ile Arg Ser Ser 
    50                  55                  60                  


Glu Asp Pro Asn Glu Asp Ile Val Glu Arg Asn Ile Arg Ile Ile Val 
65                  70                  75                  80  


Pro Leu Asn Asn Arg Glu Asn Ile Ser Asp Pro Thr Ser Pro Leu Arg 
                85                  90                  95      


Thr Arg Phe Val Tyr His Leu Ser Asp Leu Cys Lys Lys Cys Asp Pro 
            100                 105                 110         


Thr Glu Val Glu Leu Asp Asn Gln Ile Val Thr Ala Thr Gln Ser Asn 
        115                 120                 125             


Ile Cys Asp Glu Asp Ser Ala Thr Glu Thr Cys Tyr Thr Tyr Asp Arg 
    130                 135                 140                 


Asn Lys Cys Tyr Thr Ala Val Val Pro Leu Val Tyr Gly 
145                 150                 155         


<210>  7363
<211>  285
<212>  PRT
<213>  Homo Sapiens

<400>  7363

Met Ala Gly Gly Trp Ala Gln Gly Ser Arg Arg Ala Ala Arg Leu Pro 
1               5                   10                  15      


Glu Gly Gly Arg Leu Met Ala Pro Ala Ser Arg Leu Leu Ala Leu Trp 
            20                  25                  30          


Ala Leu Ala Ala Val Ala Leu Pro Gly Ser Gly Ala Glu Gly Asp Gly 
        35                  40                  45              


Gly Trp Arg Pro Gly Gly Pro Gly Ala Val Ala Glu Glu Glu Arg Cys 
    50                  55                  60                  


Thr Val Glu Arg Arg Ala Asp Leu Thr Tyr Ala Glu Phe Val Gln Gln 
65                  70                  75                  80  


Tyr Ala Phe Val Arg Pro Val Ile Leu Gln Gly Leu Thr Asp Asn Ser 
                85                  90                  95      


Arg Phe Arg Ala Leu Cys Ser Arg Asp Arg Leu Leu Ala Ser Phe Gly 
            100                 105                 110         


Asp Arg Val Val Arg Leu Ser Thr Ala Asn Thr Tyr Ser Tyr His Lys 
        115                 120                 125             


Val Asp Leu Pro Phe Gln Glu Tyr Val Glu Gln Leu Leu His Pro Gln 
    130                 135                 140                 


Asp Pro Thr Ser Leu Gly Asn Asp Thr Leu Tyr Phe Phe Gly Asp Asn 
145                 150                 155                 160 


Asn Phe Thr Glu Trp Ala Ser Leu Phe Arg His Tyr Ser Pro Pro Pro 
                165                 170                 175     


Phe Gly Leu Leu Gly Thr Ala Pro Ala Tyr Ser Phe Gly Ile Ala Gly 
            180                 185                 190         


Ala Gly Ser Gly Val Pro Phe His Trp His Gly Pro Gly Tyr Ser Glu 
        195                 200                 205             


Val Ile Tyr Gly Arg Lys Arg Trp Phe Leu Tyr Pro Pro Glu Lys Thr 
    210                 215                 220                 


Pro Glu Phe His Pro Asn Lys Thr Thr Leu Ala Trp Leu Arg Asp Thr 
225                 230                 235                 240 


Tyr Pro Ala Leu Pro Pro Ser Ala Arg Pro Leu Glu Cys Thr Ile Arg 
                245                 250                 255     


Ala Gly Glu Val Leu Tyr Phe Pro Asp Arg Trp Trp His Ala Thr Leu 
            260                 265                 270         


Asn Leu Asp Thr Ser Val Phe Ile Ser Thr Phe Leu Gly 
        275                 280                 285 


<210>  7364
<211>  264
<212>  PRT
<213>  Homo Sapiens

<400>  7364

Met Ala Pro Ala Ser Arg Leu Leu Ala Leu Trp Ala Leu Ala Ala Val 
1               5                   10                  15      


Ala Leu Pro Gly Ser Gly Ala Glu Gly Asp Gly Gly Trp Arg Pro Gly 
            20                  25                  30          


Gly Pro Gly Ala Val Ala Glu Glu Glu Arg Cys Thr Val Glu Arg Arg 
        35                  40                  45              


Ala Asp Leu Thr Tyr Ala Glu Phe Val Gln Gln Tyr Ala Phe Val Arg 
    50                  55                  60                  


Pro Val Ile Leu Gln Gly Leu Thr Asp Asn Ser Arg Phe Arg Ala Leu 
65                  70                  75                  80  


Cys Ser Arg Asp Arg Leu Leu Ala Ser Phe Gly Asp Arg Val Val Arg 
                85                  90                  95      


Leu Ser Thr Ala Asn Thr Tyr Ser Tyr His Lys Val Asp Leu Pro Phe 
            100                 105                 110         


Gln Glu Tyr Val Glu Gln Leu Leu His Pro Gln Asp Pro Thr Ser Leu 
        115                 120                 125             


Gly Asn Asp Thr Leu Tyr Phe Phe Gly Asp Asn Asn Phe Thr Glu Trp 
    130                 135                 140                 


Ala Ser Leu Phe Arg His Tyr Ser Pro Pro Pro Phe Gly Leu Leu Gly 
145                 150                 155                 160 


Thr Ala Pro Ala Tyr Ser Phe Gly Ile Ala Gly Ala Gly Ser Gly Val 
                165                 170                 175     


Pro Phe His Trp His Gly Pro Gly Tyr Ser Glu Val Ile Tyr Gly Arg 
            180                 185                 190         


Lys Arg Trp Phe Leu Tyr Pro Pro Glu Lys Thr Pro Glu Phe His Pro 
        195                 200                 205             


Asn Lys Thr Thr Leu Ala Trp Leu Arg Asp Thr Tyr Pro Ala Leu Pro 
    210                 215                 220                 


Pro Ser Ala Arg Pro Leu Glu Cys Thr Ile Arg Ala Gly Glu Val Leu 
225                 230                 235                 240 


Tyr Phe Pro Asp Arg Trp Trp His Ala Thr Leu Asn Leu Asp Thr Ser 
                245                 250                 255     


Val Phe Ile Ser Thr Phe Leu Gly 
            260                 


<210>  7365
<211>  219
<212>  PRT
<213>  Homo Sapiens

<400>  7365

Met Ala Pro Ala Ser Arg Leu Leu Ala Leu Trp Ala Leu Ala Ala Val 
1               5                   10                  15      


Ala Leu Pro Gly Ser Gly Ala Glu Gly Asp Gly Gly Trp Arg Pro Gly 
            20                  25                  30          


Gly Pro Gly Ala Val Ala Glu Glu Glu Arg Cys Thr Val Glu Arg Arg 
        35                  40                  45              


Ala Asp Leu Thr Tyr Ala Glu Phe Val Gln Gln Tyr Ala Phe Val Arg 
    50                  55                  60                  


Pro Val Ile Leu Gln Gly Leu Thr Asp Asn Ser Arg Phe Arg Ala Leu 
65                  70                  75                  80  


Cys Ser Arg Asp Arg Leu Leu Ala Ser Phe Gly Asp Arg Val Val Arg 
                85                  90                  95      


Leu Ser Thr Ala Asn Thr Tyr Ser Tyr His Lys Val Asp Leu Pro Phe 
            100                 105                 110         


Gln Glu Tyr Val Glu Gln Leu Leu His Pro Gln Asp Pro Thr Ser Leu 
        115                 120                 125             


Gly Asn Asp Thr Leu Tyr Phe Phe Gly Asp Asn Asn Phe Thr Glu Trp 
    130                 135                 140                 


Ala Ser Leu Phe Arg His Tyr Ser Pro Pro Pro Phe Gly Leu Leu Gly 
145                 150                 155                 160 


Thr Ala Pro Ala Tyr Ser Phe Gly Ile Ala Gly Ala Gly Ser Gly Val 
                165                 170                 175     


Pro Phe His Trp His Gly Pro Gly Tyr Ser Glu Val Ile Tyr Gly Arg 
            180                 185                 190         


Lys Val Leu Tyr Phe Pro Asp Arg Trp Trp His Ala Thr Leu Asn Leu 
        195                 200                 205             


Asp Thr Ser Val Phe Ile Ser Thr Phe Leu Gly 
    210                 215                 


<210>  7366
<211>  234
<212>  PRT
<213>  Homo Sapiens

<400>  7366

Met Ala Pro Ala Ser Arg Leu Leu Ala Leu Trp Ala Leu Ala Ala Val 
1               5                   10                  15      


Ala Leu Pro Gly Ser Gly Ala Glu Gly Asp Gly Gly Trp Tyr Ala Phe 
            20                  25                  30          


Val Arg Pro Val Ile Leu Gln Gly Leu Thr Asp Asn Ser Arg Phe Arg 
        35                  40                  45              


Ala Leu Cys Ser Arg Asp Arg Leu Leu Ala Ser Phe Gly Asp Arg Val 
    50                  55                  60                  


Val Arg Leu Ser Thr Ala Asn Thr Tyr Ser Tyr His Lys Val Asp Leu 
65                  70                  75                  80  


Pro Phe Gln Glu Tyr Val Glu Gln Leu Leu His Pro Gln Asp Pro Thr 
                85                  90                  95      


Ser Leu Gly Asn Asp Thr Leu Tyr Phe Phe Gly Asp Asn Asn Phe Thr 
            100                 105                 110         


Glu Trp Ala Ser Leu Phe Arg His Tyr Ser Pro Pro Pro Phe Gly Leu 
        115                 120                 125             


Leu Gly Thr Ala Pro Ala Tyr Ser Phe Gly Ile Ala Gly Ala Gly Ser 
    130                 135                 140                 


Gly Val Pro Phe His Trp His Gly Pro Gly Tyr Ser Glu Val Ile Tyr 
145                 150                 155                 160 


Gly Arg Lys Arg Trp Phe Leu Tyr Pro Pro Glu Lys Thr Pro Glu Phe 
                165                 170                 175     


His Pro Asn Lys Thr Thr Leu Ala Trp Leu Arg Asp Thr Tyr Pro Ala 
            180                 185                 190         


Leu Pro Pro Ser Ala Arg Pro Leu Glu Cys Thr Ile Arg Ala Gly Glu 
        195                 200                 205             


Val Leu Tyr Phe Pro Asp Arg Trp Trp His Ala Thr Leu Asn Leu Asp 
    210                 215                 220                 


Thr Ser Val Phe Ile Ser Thr Phe Leu Gly 
225                 230                 


<210>  7367
<211>  81
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7367

Xaa Trp Thr Cys Pro Ser Arg Ser Met Trp Ser Ser Cys Cys Thr Pro 
1               5                   10                  15      


Arg Thr Pro Pro Pro Trp Ala Met Thr Pro Cys Thr Ser Ser Gly Thr 
            20                  25                  30          


Thr Thr Ser Pro Ser Gly Pro Leu Ser Phe Gly Thr Thr Pro His Pro 
        35                  40                  45              


His Leu Ala Cys Trp Glu Pro Leu Gln Leu Thr Ala Leu Glu Ser Gln 
    50                  55                  60                  


Glu Leu Ala Arg Gly Cys Pro Ser Thr Gly Met Asp Pro Gly Thr Gln 
65                  70                  75                  80  


Lys 
    


<210>  7368
<211>  331
<212>  PRT
<213>  Homo Sapiens

<400>  7368

Met Ser Met Thr Thr Arg Ala Trp Glu Glu Leu Asp Gly Gly Leu Gly 
1               5                   10                  15      


Ser Cys Gln Ala Leu Glu Asp His Ser Ala Leu Ala Glu Thr Gln Glu 
            20                  25                  30          


Asp Arg Ala Ser Ala Thr Pro Arg Leu Ala Asp Ser Gly Ser Val Pro 
        35                  40                  45              


His Asp Ser Gln Val Ala Glu Gly Pro Ser Val Asp Thr Arg Pro Lys 
    50                  55                  60                  


Lys Met Glu Lys Glu Pro Ala Ala Arg Gly Thr Pro Gly Thr Gly Lys 
65                  70                  75                  80  


Glu Arg Leu Lys Ala Gly Ala Ser Pro Arg Ser Val Pro Ala Arg Lys 
                85                  90                  95      


Lys Ala Gln Thr Ala Pro Pro Leu Gln Pro Pro Pro Pro Pro Pro Ala 
            100                 105                 110         


Leu Ser Glu Glu Leu Pro Trp Gly Asp Leu Ser Leu Asn Lys Cys Leu 
        115                 120                 125             


Val Leu Ala Ser Leu Val Ala Leu Leu Gly Ser Ala Phe Gln Leu Cys 
    130                 135                 140                 


Arg Asp Ala Val Pro Gly Glu Ala Ala Leu Gln Ala Arg Val Pro Glu 
145                 150                 155                 160 


Pro Trp Val Pro Pro Ser Ser Ala Pro Arg Glu Pro Ser Ser Pro Leu 
                165                 170                 175     


Pro Lys Phe Glu Ala Gln Ala Pro Pro Ser Ala Pro Pro Ala Pro Arg 
            180                 185                 190         


Ala Glu Ala Glu Val Arg Pro Lys Ile Pro Gly Ser Arg Glu Ala Ala 
        195                 200                 205             


Glu Asn Asp Glu Glu Glu Pro Gly Glu Ala Thr Gly Glu Ala Val Arg 
    210                 215                 220                 


Glu Asp Arg Val Thr Leu Ala Asp Arg Gly Pro Lys Glu Arg Pro Arg 
225                 230                 235                 240 


Arg Glu Gly Lys Pro Arg Lys Glu Lys Pro Arg Lys Glu Glu Arg Pro 
                245                 250                 255     


Lys Lys Glu Arg Pro Arg Lys Glu Glu Arg Pro Arg Ala Ala Arg Glu 
            260                 265                 270         


Pro Arg Glu Ala Leu Pro Gln Arg Trp Glu Ser Arg Glu Gly Gly His 
        275                 280                 285             


Arg Pro Trp Ala Arg Asp Ser Arg Asp Ala Glu Pro Arg Lys Lys Gln 
    290                 295                 300                 


Ala Trp Val Ser Pro Arg Arg Pro Asp Glu Glu Gln Arg Pro Gly Ser 
305                 310                 315                 320 


Arg Gln Lys Leu Arg Ala Gly Lys Gly Arg Asp 
                325                 330     


<210>  7369
<211>  206
<212>  PRT
<213>  Homo Sapiens

<400>  7369

Glu Asn Leu Lys Arg Leu Lys Cys Leu Arg Arg Tyr Arg Gln Arg Tyr 
1               5                   10                  15      


Gly Val Glu Ala Leu Leu His Arg Gln Leu Lys Glu Arg Arg Met Leu 
            20                  25                  30          


Ala Thr Asp Gly Ala Ala Gln Gln Ala His Thr Thr Arg Ser Ser Gln 
        35                  40                  45              


Arg Cys Leu Ala Phe Val Asp Asp Val Arg Cys Ser Asn Gln Ser Leu 
    50                  55                  60                  


Pro Met Thr Arg His Cys Leu Thr His Ile Cys Gln Asp Thr Asn Gln 
65                  70                  75                  80  


Val Leu Phe Lys Cys Cys Gln Gly Ser Glu Glu Val Pro Cys Asn Lys 
                85                  90                  95      


Pro Val Pro Val Ser Leu Ser Glu Asp Pro Cys Cys Pro Leu His Phe 
            100                 105                 110         


Gln Leu Pro Pro Gln Met Tyr Lys Pro Glu Gln Asp Leu Asp Val Val 
        115                 120                 125             


Gly Asp Gly Met Gln Cys Pro Pro Ser Pro Leu Leu Phe Asp Pro Ser 
    130                 135                 140                 


Leu Thr Leu Glu Asp His Leu Val Lys Glu Ile Ala Glu Asp Pro Val 
145                 150                 155                 160 


Asp Ile Leu Gly Gln Met Gln Met Ala Gly Asp Gly Cys Arg Ser Gln 
                165                 170                 175     


Gly Ser Arg Asn Ser Glu Lys Ala Ser Ala Pro Leu Ser Gln Ser Gly 
            180                 185                 190         


Leu Ala Thr Ala Asn Gly Lys Pro Glu Pro Thr Ser Ile Ser 
        195                 200                 205     


<210>  7370
<211>  675
<212>  PRT
<213>  Homo Sapiens

<400>  7370

Met Ala Val Leu Phe Pro Leu Ser Ser Cys Gly Trp Ala Ala Ile Ser 
1               5                   10                  15      


Leu Phe Leu Ser Ala Gln Ser Cys Tyr Ser Ala Ser Lys Gln Cys Gln 
            20                  25                  30          


Ser Gln Ser Pro Ser Cys Arg Leu Pro Gly Ala Arg Ile Ser Gly Asp 
        35                  40                  45              


Trp Ser Arg Arg Thr Lys Trp Arg Ser His Arg Leu Pro Arg Pro Gly 
    50                  55                  60                  


Pro Val Val Arg Ser Glu Ala Gly Arg Asp Lys Gly Gly Val Arg Gly 
65                  70                  75                  80  


Gly Gly Val Ala Ala Ala Trp Gly Trp Cys Cys Arg Phe Pro Ser Cys 
                85                  90                  95      


Cys Ser Cys Ala Ser Pro Glu Asp Thr Phe Ser Val Val Trp Phe Gly 
            100                 105                 110         


Val Gly Pro Gly Met Glu Gly His Ala Lys Gly Arg Gln Ser His Arg 
        115                 120                 125             


Cys Leu Trp Arg Leu Gly Glu Gly Gly Gly Asp Leu Arg Ser Val Pro 
    130                 135                 140                 


Tyr Gly Asp Asp Phe Cys Met Ser Phe Gly Asn Cys Pro Arg Asp Leu 
145                 150                 155                 160 


Cys Gly Ala Gly Ile Phe Gly Lys Gly Lys Gly Phe Leu Val Phe Arg 
                165                 170                 175     


Leu Thr Pro Gln Val Leu Val Met Asn Arg Ile Arg Ile His Val Leu 
            180                 185                 190         


Pro Thr Asn Arg Gly Arg Ile Thr Pro Val Pro Arg Ser Gln Glu Pro 
        195                 200                 205             


Leu Ser Cys Ala Phe Thr His Arg Pro Cys Ser His Pro Arg Leu Glu 
    210                 215                 220                 


Gly Gln Glu Phe Cys Ile Lys His Ile Leu Glu Asp Lys Asn Ala Pro 
225                 230                 235                 240 


Phe Lys Gln Cys Ser Tyr Ile Ser Thr Lys Asn Gly Lys Arg Cys Pro 
                245                 250                 255     


Asn Ala Ala Pro Lys Pro Glu Lys Lys Asp Gly Val Ser Phe Cys Ala 
            260                 265                 270         


Glu His Val Arg Arg Asn Ala Leu Ala Leu His Ala Gln Met Lys Lys 
        275                 280                 285             


Thr Asn Pro Gly Pro Val Gly Glu Thr Leu Leu Cys Gln Leu Ser Ser 
    290                 295                 300                 


Tyr Ala Lys Thr Glu Leu Gly Ser Gln Thr Pro Glu Ser Ser Arg Ser 
305                 310                 315                 320 


Glu Ala Ser Arg Ile Leu Asp Glu Asp Ser Trp Ser Asp Gly Glu Gln 
                325                 330                 335     


Glu Pro Ile Thr Val Asp Gln Thr Trp Arg Gly Asp Pro Asp Ser Glu 
            340                 345                 350         


Ala Asp Ser Ile Asp Ser Asp Gln Glu Asp Pro Leu Lys His Ala Gly 
        355                 360                 365             


Val Tyr Thr Ala Glu Glu Val Ala Leu Ile Met Arg Glu Lys Leu Ile 
    370                 375                 380                 


Arg Leu Gln Ser Leu Tyr Ile Asp Gln Phe Lys Arg Leu Gln His Leu 
385                 390                 395                 400 


Leu Lys Glu Lys Lys Arg Arg Tyr Leu His Asn Arg Lys Val Glu His 
                405                 410                 415     


Glu Ala Leu Gly Ser Ser Leu Leu Thr Gly Pro Glu Gly Leu Leu Ala 
            420                 425                 430         


Lys Glu Arg Glu Asn Leu Lys Arg Leu Lys Cys Leu Arg Arg Tyr Arg 
        435                 440                 445             


Gln Arg Tyr Gly Val Glu Ala Leu Leu His Arg Gln Leu Lys Glu Arg 
    450                 455                 460                 


Arg Met Leu Ala Thr Asp Gly Ala Ala Gln Gln Ala His Thr Thr Arg 
465                 470                 475                 480 


Ser Ser Gln Arg Cys Leu Ala Phe Val Asp Asp Val Arg Cys Ser Asn 
                485                 490                 495     


Gln Ser Leu Pro Met Thr Arg His Cys Leu Thr His Ile Cys Gln Asp 
            500                 505                 510         


Thr Asn Gln Val Leu Phe Lys Cys Cys Gln Gly Ser Glu Glu Val Pro 
        515                 520                 525             


Cys Asn Lys Pro Val Pro Val Ser Leu Ser Glu Asp Pro Cys Cys Pro 
    530                 535                 540                 


Leu His Phe Gln Leu Pro Pro Gln Met Tyr Lys Pro Glu Gln Val Leu 
545                 550                 555                 560 


Ser Val Pro Asp Asp Leu Glu Ala Gly Pro Met Asp Leu Tyr Leu Ser 
                565                 570                 575     


Ala Ala Glu Leu Gln Pro Thr Glu Ser Leu Pro Leu Glu Phe Ser Asp 
            580                 585                 590         


Asp Leu Asp Val Val Gly Asp Gly Met Gln Cys Pro Pro Ser Pro Leu 
        595                 600                 605             


Leu Phe Asp Pro Ser Leu Thr Leu Glu Asp His Leu Val Lys Glu Ile 
    610                 615                 620                 


Ala Glu Asp Pro Val Asp Ile Leu Gly Gln Met Gln Met Ala Gly Asp 
625                 630                 635                 640 


Gly Cys Arg Ser Gln Gly Ser Arg Asn Ser Glu Lys Ala Ser Ala Pro 
                645                 650                 655     


Leu Ser Gln Ser Gly Leu Ala Thr Ala Asn Gly Lys Pro Glu Pro Thr 
            660                 665                 670         


Ser Ile Ser 
        675 


<210>  7371
<211>  69
<212>  PRT
<213>  Homo Sapiens

<400>  7371

Met Asn Arg Ile Arg Ile His Val Leu Pro Thr Asn Arg Gly Arg Ile 
1               5                   10                  15      


Thr Pro Val Pro Arg Ser Gln Glu Pro Leu Ser Cys Ala Phe Thr His 
            20                  25                  30          


Arg Pro Cys Ser His Pro Arg Leu Glu Gly Gln Glu Phe Cys Ile Lys 
        35                  40                  45              


His Ile Leu Glu Asp Lys Asn Ala Pro Phe Lys Gln Cys Ser Tyr Ile 
    50                  55                  60                  


Ser Thr Lys Asn Gly 
65                  


<210>  7372
<211>  108
<212>  PRT
<213>  Homo Sapiens

<400>  7372

Met Asn Arg Ile Arg Ile His Val Leu Pro Thr Asn Arg Gly Arg Ile 
1               5                   10                  15      


Thr Pro Val Pro Arg Ser Gln Glu Pro Leu Ser Cys Ala Phe Thr His 
            20                  25                  30          


Arg Pro Cys Ser His Pro Arg Leu Glu Gly Gln Glu Phe Cys Ile Lys 
        35                  40                  45              


His Ile Leu Glu Asp Lys Asn Ala Pro Phe Lys Gln Cys Ser Tyr Ile 
    50                  55                  60                  


Ser Thr Lys Asn Gly Lys Arg Cys Pro Asn Ala Ala Pro Lys Pro Glu 
65                  70                  75                  80  


Lys Lys Asp Gly Val Ser Phe Cys Ala Glu His Val Arg Arg Asn Ala 
                85                  90                  95      


Leu Ala Leu His Ala Gln Met Lys Lys Thr Asn Pro 
            100                 105             


<210>  7373
<211>  492
<212>  PRT
<213>  Homo Sapiens

<400>  7373

Met Asn Arg Ile Arg Ile His Val Leu Pro Thr Asn Arg Gly Arg Ile 
1               5                   10                  15      


Thr Pro Val Pro Arg Ser Gln Glu Pro Leu Ser Cys Ala Phe Thr His 
            20                  25                  30          


Arg Pro Cys Ser His Pro Arg Leu Glu Gly Gln Glu Phe Cys Ile Lys 
        35                  40                  45              


His Ile Leu Glu Asp Lys Asn Ala Pro Phe Lys Gln Cys Ser Tyr Ile 
    50                  55                  60                  


Ser Thr Lys Asn Gly Lys Arg Cys Pro Asn Ala Ala Pro Lys Pro Glu 
65                  70                  75                  80  


Lys Lys Asp Gly Val Ser Phe Cys Ala Glu His Val Arg Arg Asn Ala 
                85                  90                  95      


Leu Ala Leu His Ala Gln Met Lys Lys Thr Asn Pro Gly Pro Val Gly 
            100                 105                 110         


Glu Thr Leu Leu Cys Gln Leu Ser Ser Tyr Ala Lys Thr Glu Leu Gly 
        115                 120                 125             


Ser Gln Thr Pro Glu Ser Ser Arg Ser Glu Ala Ser Arg Ile Leu Asp 
    130                 135                 140                 


Glu Asp Ser Trp Ser Asp Gly Glu Gln Glu Pro Ile Thr Val Asp Gln 
145                 150                 155                 160 


Thr Trp Arg Gly Asp Pro Asp Ser Glu Ala Asp Ser Ile Asp Ser Asp 
                165                 170                 175     


Gln Glu Asp Pro Leu Lys His Ala Gly Val Tyr Thr Ala Glu Glu Val 
            180                 185                 190         


Ala Leu Ile Met Arg Glu Lys Leu Ile Arg Leu Gln Ser Leu Tyr Ile 
        195                 200                 205             


Asp Gln Phe Lys Arg Leu Gln His Leu Leu Lys Glu Lys Lys Arg Arg 
    210                 215                 220                 


Tyr Leu His Asn Arg Lys Val Glu His Glu Ala Leu Gly Ser Ser Leu 
225                 230                 235                 240 


Leu Thr Gly Pro Glu Gly Leu Leu Ala Lys Glu Arg Glu Asn Leu Lys 
                245                 250                 255     


Arg Leu Lys Cys Leu Arg Arg Tyr Arg Gln Arg Tyr Gly Val Glu Ala 
            260                 265                 270         


Leu Leu His Arg Gln Leu Lys Glu Arg Arg Met Leu Ala Thr Asp Gly 
        275                 280                 285             


Ala Ala Gln Gln Ala His Thr Thr Arg Ser Ser Gln Arg Cys Leu Ala 
    290                 295                 300                 


Phe Val Asp Asp Val Arg Cys Ser Asn Gln Ser Leu Pro Met Thr Arg 
305                 310                 315                 320 


His Cys Leu Thr His Ile Cys Gln Asp Thr Asn Gln Val Leu Phe Lys 
                325                 330                 335     


Cys Cys Gln Gly Ser Glu Glu Val Pro Cys Asn Lys Pro Val Pro Val 
            340                 345                 350         


Ser Leu Ser Glu Asp Pro Cys Cys Pro Leu His Phe Gln Leu Pro Pro 
        355                 360                 365             


Gln Met Tyr Lys Pro Glu Gln Val Leu Ser Val Pro Asp Asp Leu Glu 
    370                 375                 380                 


Ala Gly Pro Met Asp Leu Tyr Leu Ser Ala Ala Glu Leu Gln Pro Thr 
385                 390                 395                 400 


Glu Ser Leu Pro Leu Glu Phe Ser Asp Asp Leu Asp Val Val Gly Asp 
                405                 410                 415     


Gly Met Gln Cys Pro Pro Ser Pro Leu Leu Phe Asp Pro Ser Leu Thr 
            420                 425                 430         


Leu Glu Asp His Leu Val Lys Glu Ile Ala Glu Asp Pro Val Asp Ile 
        435                 440                 445             


Leu Gly Gln Met Gln Met Ala Gly Asp Gly Cys Arg Ser Gln Gly Ser 
    450                 455                 460                 


Arg Asn Ser Glu Lys Ala Ser Ala Pro Leu Ser Gln Ser Gly Leu Ala 
465                 470                 475                 480 


Thr Ala Asn Gly Lys Pro Glu Pro Thr Ser Ile Ser 
                485                 490         


<210>  7374
<211>  454
<212>  PRT
<213>  Homo Sapiens

<400>  7374

Met Asn Arg Ile Arg Ile His Val Leu Pro Thr Asn Arg Gly Arg Ile 
1               5                   10                  15      


Thr Pro Val Pro Arg Ser Gln Glu Pro Leu Ser Cys Ala Phe Thr His 
            20                  25                  30          


Arg Pro Cys Ser His Pro Arg Leu Glu Gly Gln Glu Phe Cys Ile Lys 
        35                  40                  45              


His Ile Leu Glu Asp Lys Asn Ala Pro Phe Lys Gln Cys Ser Tyr Ile 
    50                  55                  60                  


Ser Thr Lys Asn Gly Lys Arg Cys Pro Asn Ala Ala Pro Lys Pro Glu 
65                  70                  75                  80  


Lys Lys Asp Gly Val Ser Phe Cys Ala Glu His Val Arg Arg Asn Ala 
                85                  90                  95      


Leu Ala Leu His Ala Gln Met Lys Lys Thr Asn Pro Gly Pro Val Gly 
            100                 105                 110         


Glu Thr Leu Leu Cys Gln Leu Ser Ser Tyr Ala Lys Thr Glu Leu Gly 
        115                 120                 125             


Ser Gln Thr Pro Glu Ser Ser Arg Ser Glu Ala Ser Arg Ile Leu Asp 
    130                 135                 140                 


Glu Asp Ser Trp Ser Asp Gly Glu Gln Glu Pro Ile Thr Val Asp Gln 
145                 150                 155                 160 


Thr Trp Arg Gly Asp Pro Asp Ser Glu Ala Asp Ser Ile Asp Ser Asp 
                165                 170                 175     


Gln Glu Asp Pro Leu Lys His Ala Gly Val Tyr Thr Ala Glu Glu Val 
            180                 185                 190         


Ala Leu Ile Met Arg Glu Lys Leu Ile Arg Leu Gln Ser Leu Tyr Ile 
        195                 200                 205             


Asp Gln Phe Lys Arg Leu Gln His Leu Leu Lys Glu Lys Lys Arg Arg 
    210                 215                 220                 


Tyr Leu His Asn Arg Lys Val Glu His Glu Ala Leu Gly Ser Ser Leu 
225                 230                 235                 240 


Leu Thr Gly Pro Glu Gly Leu Leu Ala Lys Glu Arg Glu Asn Leu Lys 
                245                 250                 255     


Arg Leu Lys Cys Leu Arg Arg Tyr Arg Gln Arg Tyr Gly Val Glu Ala 
            260                 265                 270         


Leu Leu His Arg Gln Leu Lys Glu Arg Arg Met Leu Ala Thr Asp Gly 
        275                 280                 285             


Ala Ala Gln Gln Ala His Thr Thr Arg Ser Ser Gln Arg Cys Leu Ala 
    290                 295                 300                 


Phe Val Asp Asp Val Arg Cys Ser Asn Gln Ser Leu Pro Met Thr Arg 
305                 310                 315                 320 


His Cys Leu Thr His Ile Cys Gln Asp Thr Asn Gln Val Leu Phe Lys 
                325                 330                 335     


Cys Cys Gln Gly Ser Glu Glu Val Pro Cys Asn Lys Pro Val Pro Val 
            340                 345                 350         


Ser Leu Ser Glu Asp Pro Cys Cys Pro Leu His Phe Gln Leu Pro Pro 
        355                 360                 365             


Gln Met Tyr Lys Pro Glu Gln Asp Leu Asp Val Val Gly Asp Gly Met 
    370                 375                 380                 


Gln Cys Pro Pro Ser Pro Leu Leu Phe Asp Pro Ser Leu Thr Leu Glu 
385                 390                 395                 400 


Asp His Leu Val Lys Glu Ile Ala Glu Asp Pro Gly Gln Met Gln Met 
                405                 410                 415     


Ala Gly Asp Gly Cys Arg Ser Gln Gly Ser Arg Asn Ser Glu Lys Ala 
            420                 425                 430         


Ser Ala Pro Leu Ser Gln Ser Gly Leu Ala Thr Ala Asn Gly Lys Pro 
        435                 440                 445             


Glu Pro Thr Ser Ile Ser 
    450                 


<210>  7375
<211>  155
<212>  PRT
<213>  Homo Sapiens

<400>  7375

Met Asn Arg Ile Arg Ile His Val Leu Pro Thr Asn Arg Gly Arg Ile 
1               5                   10                  15      


Thr Pro Val Pro Arg Ser Gln Glu Pro Leu Ser Cys Ala Phe Thr His 
            20                  25                  30          


Arg Pro Cys Ser His Pro Arg Leu Glu Gly Gln Glu Phe Cys Ile Lys 
        35                  40                  45              


His Ile Leu Glu Asp Lys Asn Ala Pro Phe Lys Gln Cys Ser Tyr Ile 
    50                  55                  60                  


Ser Thr Lys Asn Gly Lys Arg Cys Pro Asn Ala Ala Pro Lys Pro Glu 
65                  70                  75                  80  


Lys Lys Asp Gly Val Ser Phe Cys Ala Glu His Val Arg Arg Asn Ala 
                85                  90                  95      


Leu Ala Leu His Ala Gln Met Lys Lys Thr Asn Pro Gly Pro Val Gly 
            100                 105                 110         


Glu Thr Leu Leu Cys Gln Leu Ser Ser Tyr Ala Lys Thr Glu Leu Gly 
        115                 120                 125             


Ser Gln Thr Pro Glu Ser Ser Arg Ser Glu Ala Ser Arg Ile Leu Asp 
    130                 135                 140                 


Met Leu Val Ser Thr Gln Gln Lys Lys Trp Pro 
145                 150                 155 


<210>  7376
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  7376

Met Asn Arg Ile Arg Ile His Val Leu Pro Thr Asn Arg Gly Arg Ile 
1               5                   10                  15      


Thr Pro Val Pro Arg Val Ser Phe Cys Ala Glu His Val Arg Arg Asn 
            20                  25                  30          


Ala Leu Ala Leu His Ala Gln Met Lys Lys Thr Asn Pro Gly Pro Val 
        35                  40                  45              


Gly Glu Thr Leu Leu Cys Gln Leu Ser Ser Tyr Ala Lys Thr Glu Leu 
    50                  55                  60                  


Gly Ser Gln Thr Pro Glu Ser Ser Arg Ser Glu Ala Ser Arg Ile Leu 
65                  70                  75                  80  


Asp Glu Asp Ser Trp Ser Asp Gly Glu Gln Glu Pro Ile Thr Val Asp 
                85                  90                  95      


Gln Thr Trp Arg Gly Asp Pro Asp Ser Glu Ala Asp Ser Ile Asp Ser 
            100                 105                 110         


Asp Gln Glu Asp Pro Leu Lys His Ala Gly Val Tyr Thr Ala Glu Glu 
        115                 120                 125             


Val Ala Leu Ile Met 
    130             


<210>  7377
<211>  74
<212>  PRT
<213>  Homo Sapiens

<400>  7377

Pro Asn Ala Ala Pro Lys Pro Glu Lys Lys Asp Gly Val Ser Phe Cys 
1               5                   10                  15      


Ala Glu His Val Arg Arg Asn Ala Leu Ala Leu His Ala Gln Met Lys 
            20                  25                  30          


Lys Thr Asn Pro Gly Pro Val Gly Glu Thr Leu Leu Cys Gln Leu Ser 
        35                  40                  45              


Ser Tyr Ala Lys Thr Glu Leu Gly Ser Gln Thr Pro Glu Ser Ser Arg 
    50                  55                  60                  


Ser Glu Ala Ser Arg Ile Leu Gly Leu Gly 
65                  70                  


<210>  7378
<211>  340
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7378

Xaa Leu Pro Thr Asn Arg Gly Arg Ile Thr Pro Val Pro Arg Ser Gln 
1               5                   10                  15      


Glu Pro Leu Ser Cys Ala Phe Thr His Arg Pro Cys Ser His Pro Arg 
            20                  25                  30          


Leu Glu Gly Gln Glu Phe Cys Ile Lys His Ile Leu Glu Asp Lys Asn 
        35                  40                  45              


Ala Pro Phe Lys Gln Cys Ser Tyr Ile Ser Thr Lys Asn Gly Lys Arg 
    50                  55                  60                  


Cys Pro Asn Ala Ala Pro Lys Pro Glu Lys Lys Asp Gly Val Ser Phe 
65                  70                  75                  80  


Cys Ala Glu His Val Arg Arg Asn Ala Leu Ala Leu His Ala Gln Met 
                85                  90                  95      


Lys Lys Thr Asn Pro Gly Pro Val Gly Glu Thr Leu Leu Cys Gln Leu 
            100                 105                 110         


Ser Ser Tyr Ala Lys Thr Glu Leu Gly Ser Gln Thr Pro Glu Ser Ser 
        115                 120                 125             


Arg Ser Glu Ala Ser Arg Ile Leu Asp Glu Asp Ser Trp Ser Asp Gly 
    130                 135                 140                 


Glu Gln Glu Pro Ile Thr Val Asp Gln Thr Trp Arg Gly Asp Pro Asp 
145                 150                 155                 160 


Ser Glu Ala Asp Ser Ile Asp Ser Asp Gln Glu Asp Pro Leu Lys His 
                165                 170                 175     


Ala Gly Val Tyr Thr Ala Glu Glu Val Ala Leu Ile Met Arg Glu Lys 
            180                 185                 190         


Leu Ile Arg Leu Gln Ser Leu Tyr Ile Asp Gln Phe Lys Arg Leu Gln 
        195                 200                 205             


His Leu Leu Lys Glu Lys Lys Arg Arg Tyr Leu His Asn Arg Lys Val 
    210                 215                 220                 


Glu His Glu Ala Leu Gly Ser Ser Leu Leu Thr Gly Pro Glu Gly Leu 
225                 230                 235                 240 


Leu Ala Lys Glu Arg Glu Asn Leu Lys Arg Leu Lys Cys Leu Arg Arg 
                245                 250                 255     


Tyr Arg Gln Arg Tyr Gly Val Glu Ala Leu Leu His Arg Gln Leu Lys 
            260                 265                 270         


Glu Arg Arg Met Leu Ala Thr Asp Gly Ala Ala Gln Gln Ala His Thr 
        275                 280                 285             


Thr Arg Ser Ser Gln Arg Cys Leu Ala Phe Val Asp Asp Val Arg Cys 
    290                 295                 300                 


Ser Asn Gln Ser Leu Pro Met Thr Arg His Cys Leu Thr Gln Lys Asp 
305                 310                 315                 320 


Ala Thr Ala Ile Gly Asp Leu Leu Thr Leu Tyr Cys Gly Leu Met Glu 
                325                 330                 335     


Thr Ala Leu Asp 
            340 


<210>  7379
<211>  25
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7379

Xaa Pro Glu Ser Ser Arg Ser Glu Ala Ser Arg Ile Leu Asp Met Leu 
1               5                   10                  15      


Val Ser Thr Gln Gln Lys Lys Trp Pro 
            20                  25  


<210>  7380
<211>  304
<212>  PRT
<213>  Homo Sapiens

<400>  7380

Met Leu Pro Pro Pro Arg Pro Ala Ala Ala Leu Ala Leu Pro Val Leu 
1               5                   10                  15      


Leu Leu Leu Leu Val Val Leu Thr Pro Pro Pro Thr Gly Ala Arg Pro 
            20                  25                  30          


Ser Pro Gly Pro Asp Tyr Leu Arg Arg Gly Trp Met Arg Leu Leu Ala 
        35                  40                  45              


Glu Gly Glu Gly Cys Ala Pro Cys Arg Pro Glu Glu Cys Ala Ala Pro 
    50                  55                  60                  


Arg Gly Cys Leu Ala Gly Arg Val Arg Asp Ala Cys Gly Cys Cys Trp 
65                  70                  75                  80  


Glu Cys Ala Asn Leu Glu Gly Gln Leu Cys Asp Leu Asp Pro Ser Ala 
                85                  90                  95      


His Phe Tyr Gly His Cys Gly Glu Gln Leu Glu Cys Arg Leu Asp Thr 
            100                 105                 110         


Gly Gly Asp Leu Ser Arg Gly Glu Val Pro Glu Pro Leu Cys Ala Cys 
        115                 120                 125             


Arg Ser Gln Ser Pro Leu Cys Gly Ser Asp Gly His Thr Tyr Ser Gln 
    130                 135                 140                 


Ile Cys Arg Leu Gln Glu Ala Ala Arg Ala Arg Pro Asp Ala Asn Leu 
145                 150                 155                 160 


Thr Val Ala His Pro Gly Pro Cys Glu Ser Gly Pro Gln Ile Val Ser 
                165                 170                 175     


His Pro Tyr Asp Thr Trp Asn Val Thr Gly Gln Asp Val Ile Phe Gly 
            180                 185                 190         


Cys Glu Val Phe Ala Tyr Pro Met Ala Ser Ile Glu Trp Arg Lys Asp 
        195                 200                 205             


Gly Leu Asp Ile Gln Leu Pro Gly Asp Asp Pro His Ile Ser Val Gln 
    210                 215                 220                 


Phe Arg Gly Gly Pro Gln Arg Phe Glu Val Thr Gly Trp Leu Gln Ile 
225                 230                 235                 240 


Gln Ala Val Arg Pro Ser Asp Glu Gly Thr Tyr Arg Cys Leu Gly Arg 
                245                 250                 255     


Asn Ala Leu Gly Gln Val Glu Ala Pro Ala Ser Leu Thr Val Leu Thr 
            260                 265                 270         


Pro Asp Gln Leu Asn Ser Thr Gly Ile Pro Gln Leu Arg Ser Leu Asn 
        275                 280                 285             


Leu Val Pro Glu Glu Glu Ala Glu Ser Glu Glu Asn Asp Asp Tyr Tyr 
    290                 295                 300                 


<210>  7381
<211>  230
<212>  PRT
<213>  Homo Sapiens

<400>  7381

Met Gly Ile Gln Gly Met Glu Leu Cys Ala Met Ala Val Val Val Leu 
1               5                   10                  15      


Leu Phe Ile Ala Val Leu Lys Gln Phe Gly Ile Leu Glu Pro Ile Ser 
            20                  25                  30          


Met Glu Asp Ser Ser Asp Ser Glu Leu Glu Leu Ser Thr Val Arg His 
        35                  40                  45              


Gln Pro Glu Gly Leu Asp Gln Leu Gln Ala Gln Thr Lys Phe Thr Lys 
    50                  55                  60                  


Lys Glu Leu Gln Ser Leu Tyr Arg Gly Phe Lys Asn Glu Cys Pro Thr 
65                  70                  75                  80  


Gly Leu Val Asp Glu Asp Thr Phe Lys Leu Ile Tyr Ala Gln Phe Phe 
                85                  90                  95      


Pro Gln Gly Asp Ala Thr Thr Tyr Ala His Phe Leu Phe Asn Ala Phe 
            100                 105                 110         


Asp Ala Asp Gly Asn Gly Ala Ile His Phe Glu Asp Phe Val Val Gly 
        115                 120                 125             


Leu Ser Ile Leu Leu Arg Gly Thr Val His Glu Lys Leu Lys Trp Ala 
    130                 135                 140                 


Phe Asn Leu Tyr Asp Ile Asn Lys Asp Gly Tyr Ile Thr Lys Glu Glu 
145                 150                 155                 160 


Met Leu Ala Ile Met Lys Ser Ile Tyr Asp Met Met Gly Arg His Thr 
                165                 170                 175     


Tyr Pro Ile Leu Arg Glu Asp Ala Pro Ala Glu His Val Glu Arg Phe 
            180                 185                 190         


Phe Glu Lys Met Asp Arg Asn Gln Asp Gly Val Val Thr Ile Glu Glu 
        195                 200                 205             


Phe Leu Glu Ala Cys Gln Lys Asp Glu Asn Ile Met Ser Ser Met Gln 
    210                 215                 220                 


Leu Phe Glu Asn Val Ile 
225                 230 


<210>  7382
<211>  256
<212>  PRT
<213>  Homo Sapiens

<400>  7382

Met Gln Pro Ala Lys Glu Val Thr Lys Ala Ser Asp Gly Ser Leu Leu 
1               5                   10                  15      


Gly Asp Leu Gly His Thr Pro Leu Ser Lys Lys Glu Gly Ile Lys Trp 
            20                  25                  30          


Gln Arg Pro Arg Leu Ser Arg Gln Ala Leu Met Arg Cys Cys Leu Val 
        35                  40                  45              


Lys Trp Ile Leu Ser Ser Thr Ala Pro Gln Gly Ser Asp Ser Ser Asp 
    50                  55                  60                  


Ser Glu Leu Glu Leu Ser Thr Val Arg His Gln Pro Glu Gly Leu Asp 
65                  70                  75                  80  


Gln Leu Gln Ala Gln Thr Lys Phe Thr Lys Lys Glu Leu Gln Ser Leu 
                85                  90                  95      


Tyr Arg Gly Phe Lys Asn Glu Cys Pro Thr Gly Leu Val Asp Glu Asp 
            100                 105                 110         


Thr Phe Lys Leu Ile Tyr Ala Gln Phe Phe Pro Gln Gly Asp Ala Thr 
        115                 120                 125             


Thr Tyr Ala His Phe Leu Phe Asn Ala Phe Asp Ala Asp Gly Asn Gly 
    130                 135                 140                 


Ala Ile His Phe Glu Asp Phe Val Val Gly Leu Ser Ile Leu Leu Arg 
145                 150                 155                 160 


Gly Thr Val His Glu Lys Leu Lys Trp Ala Phe Asn Leu Tyr Asp Ile 
                165                 170                 175     


Asn Lys Asp Gly Tyr Ile Thr Lys Glu Glu Met Leu Ala Ile Met Lys 
            180                 185                 190         


Ser Ile Tyr Asp Met Met Gly Arg His Thr Tyr Pro Ile Leu Arg Glu 
        195                 200                 205             


Asp Ala Pro Ala Glu His Val Glu Arg Phe Phe Glu Lys Met Asp Arg 
    210                 215                 220                 


Asn Gln Asp Gly Val Val Thr Ile Glu Glu Phe Leu Glu Ala Cys Gln 
225                 230                 235                 240 


Lys Asp Glu Asn Ile Met Ser Ser Met Gln Leu Phe Glu Asn Val Ile 
                245                 250                 255     


<210>  7383
<211>  256
<212>  PRT
<213>  Homo Sapiens

<400>  7383

Met Gln Pro Arg Lys Glu Val Thr Lys Ala Ser Asp Gly Ser Leu Leu 
1               5                   10                  15      


Gly Asp Leu Gly His Thr Pro Leu Ser Lys Lys Glu Gly Ile Lys Trp 
            20                  25                  30          


Gln Arg Pro Arg Leu Ser Arg Gln Ala Leu Met Arg Cys Cys Leu Val 
        35                  40                  45              


Lys Trp Ile Leu Ser Ser Thr Ala Pro Gln Gly Ser Asp Ser Ser Asp 
    50                  55                  60                  


Ser Glu Leu Glu Leu Ser Thr Val Arg His Gln Pro Glu Gly Leu Asp 
65                  70                  75                  80  


Gln Leu Gln Ala Gln Thr Lys Phe Thr Lys Lys Glu Leu Gln Ser Leu 
                85                  90                  95      


Tyr Arg Gly Phe Lys Asn Glu Cys Pro Thr Gly Leu Val Asp Glu Asp 
            100                 105                 110         


Thr Phe Lys Leu Ile Tyr Ala Gln Phe Phe Pro Gln Gly Asp Ala Thr 
        115                 120                 125             


Thr Tyr Ala His Phe Leu Phe Asn Ala Phe Asp Ala Asp Gly Asn Gly 
    130                 135                 140                 


Ala Ile His Phe Glu Asp Phe Val Val Gly Leu Ser Ile Leu Leu Arg 
145                 150                 155                 160 


Gly Thr Val His Glu Lys Leu Lys Trp Ala Phe Asn Leu Tyr Asp Ile 
                165                 170                 175     


Asn Lys Asp Gly Tyr Ile Thr Lys Glu Glu Met Leu Ala Ile Met Lys 
            180                 185                 190         


Ser Ile Tyr Asp Met Met Gly Arg His Thr Tyr Pro Ile Leu Arg Glu 
        195                 200                 205             


Asp Ala Pro Ala Glu His Val Glu Arg Phe Phe Glu Lys Met Asp Arg 
    210                 215                 220                 


Asn Gln Asp Gly Val Val Thr Ile Glu Glu Phe Leu Glu Ala Cys Gln 
225                 230                 235                 240 


Lys Asp Glu Asn Ile Met Ser Ser Met Gln Leu Phe Glu Asn Val Ile 
                245                 250                 255     


<210>  7384
<211>  252
<212>  PRT
<213>  Homo Sapiens

<400>  7384

Met Gly Gly Leu Arg Pro Trp Ser Arg Tyr Gly Leu Leu Val Val Ala 
1               5                   10                  15      


His Leu Leu Ala Leu Gly Leu Gly Ala Val Val Phe Gln Ala Leu Glu 
            20                  25                  30          


Gly Pro Pro Ala Cys Arg Leu Gln Ala Glu Leu Arg Ala Glu Leu Ala 
        35                  40                  45              


Ala Phe Gln Ala Glu His Arg Ala Cys Leu Pro Pro Gly Ala Leu Glu 
    50                  55                  60                  


Glu Leu Leu Gly Thr Ala Leu Ala Thr Gln Ala His Gly Val Ser Thr 
65                  70                  75                  80  


Leu Gly Asn Ser Ser Glu Gly Arg Thr Trp Asp Leu Pro Ser Ala Leu 
                85                  90                  95      


Leu Phe Ala Ala Ser Ile Leu Thr Thr Thr Gly Tyr Gly His Met Ala 
            100                 105                 110         


Pro Leu Ser Pro Gly Gly Lys Ala Phe Cys Met Val Tyr Ala Ala Leu 
        115                 120                 125             


Gly Leu Pro Ala Ser Leu Ala Leu Val Ala Thr Leu Arg His Cys Leu 
    130                 135                 140                 


Leu Pro Val Leu Ser Arg Pro Arg Ala Trp Val Ala Val His Trp Gln 
145                 150                 155                 160 


Leu Ser Pro Ala Arg Ala Ala Leu Leu Gln Ala Val Ala Leu Gly Leu 
                165                 170                 175     


Leu Val Ala Ser Ser Phe Val Leu Leu Pro Ala Leu Val Leu Trp Gly 
            180                 185                 190         


Leu Gln Gly Asp Cys Ser Leu Leu Gly Ala Val Tyr Phe Cys Phe Ser 
        195                 200                 205             


Ser Leu Ser Thr Ile Gly Leu Glu Asp Leu Leu Pro Gly Arg Gly Arg 
    210                 215                 220                 


Ser Leu His Pro Val Ile Tyr His Leu Gly Gln Leu Ala Leu Leu Gly 
225                 230                 235                 240 


Gly Gly Thr Ser Leu Gln Gly Thr Ala Trp Glu Gly 
                245                 250         


<210>  7385
<211>  252
<212>  PRT
<213>  Homo Sapiens

<400>  7385

Met Gly Gly Leu Arg Pro Trp Ser Arg Tyr Gly Leu Leu Val Val Ala 
1               5                   10                  15      


His Leu Leu Ala Leu Gly Leu Gly Ala Val Val Phe Gln Ala Leu Glu 
            20                  25                  30          


Gly Pro Pro Ala Cys Arg Leu Gln Ala Glu Leu Arg Ala Glu Leu Ala 
        35                  40                  45              


Ala Phe Gln Ala Glu His Arg Ala Cys Leu Pro Pro Gly Ala Leu Glu 
    50                  55                  60                  


Glu Leu Leu Gly Thr Ala Leu Ala Thr Gln Ala His Gly Val Ser Thr 
65                  70                  75                  80  


Leu Gly Asn Ser Ser Glu Gly Arg Thr Trp Asp Leu Pro Ser Ala Leu 
                85                  90                  95      


Leu Phe Ala Ala Ser Ile Leu Thr Thr Thr Gly Tyr Gly His Met Ala 
            100                 105                 110         


Pro Leu Ser Pro Gly Gly Lys Ala Phe Cys Met Val Tyr Ala Ala Leu 
        115                 120                 125             


Gly Leu Pro Ala Ser Leu Ala Leu Val Ala Thr Leu Arg His Cys Leu 
    130                 135                 140                 


Leu Pro Val Leu Ser Arg Pro Arg Ala Trp Val Ala Val His Trp Gln 
145                 150                 155                 160 


Leu Ser Pro Ala Arg Ala Ala Leu Leu Gln Ala Val Ala Leu Gly Leu 
                165                 170                 175     


Leu Val Ala Ser Ser Phe Val Leu Leu Pro Ala Leu Val Leu Trp Gly 
            180                 185                 190         


Leu Gln Gly Asp Cys Ser Leu Leu Gly Ala Val Tyr Phe Cys Phe Ser 
        195                 200                 205             


Ser Leu Ser Thr Ile Gly Leu Glu Asp Leu Leu Pro Gly Arg Gly Arg 
    210                 215                 220                 


Ser Leu His Pro Val Ile Tyr His Leu Gly Gln Leu Ala Leu Leu Gly 
225                 230                 235                 240 


Gly Gly Thr Ser Leu Gln Gly Thr Ala Trp Glu Gly 
                245                 250         


<210>  7386
<211>  257
<212>  PRT
<213>  Homo Sapiens

<400>  7386

Met Gly Gly Leu Arg Pro Trp Ser Arg Tyr Gly Leu Leu Val Val Ala 
1               5                   10                  15      


His Leu Leu Ala Leu Gly Leu Gly Ala Val Val Phe Gln Ala Leu Glu 
            20                  25                  30          


Gly Pro Pro Ala Cys Arg Leu Gln Ala Glu Leu Arg Ala Glu Leu Ala 
        35                  40                  45              


Ala Phe Gln Ala Glu His Arg Ala Cys Leu Pro Pro Gly Ala Leu Glu 
    50                  55                  60                  


Glu Leu Leu Gly Thr Ala Leu Ala Thr Gln Ala His Gly Val Ser Thr 
65                  70                  75                  80  


Leu Gly Asn Ser Ser Glu Gly Arg Thr Trp Asp Leu Pro Ser Ala Leu 
                85                  90                  95      


Leu Phe Ala Ala Ser Ile Leu Thr Thr Thr Gly Tyr Gly His Met Ala 
            100                 105                 110         


Pro Leu Ser Pro Gly Gly Lys Ala Phe Cys Met Val Tyr Ala Ala Leu 
        115                 120                 125             


Gly Leu Pro Ala Ser Leu Ala Leu Val Ala Thr Leu Arg His Cys Leu 
    130                 135                 140                 


Leu Pro Val Leu Ser Arg Pro Arg Ala Trp Val Ala Val His Trp Gln 
145                 150                 155                 160 


Leu Ser Pro Ala Arg Ala Ala Leu Leu Gln Ala Val Ala Leu Gly Leu 
                165                 170                 175     


Leu Val Ala Ser Ser Phe Val Leu Leu Pro Ala Leu Val Leu Trp Gly 
            180                 185                 190         


Leu Gln Gly Asp Cys Ser Leu Leu Gly Ala Val Tyr Phe Cys Phe Ser 
        195                 200                 205             


Ser Leu Ser Thr Ile Gly Leu Glu Asp Leu Leu Pro Gly Arg Gly Arg 
    210                 215                 220                 


Ser Leu His Pro Val Ile Tyr His Leu Gly Gln Leu Ala Leu Leu Gly 
225                 230                 235                 240 


Lys Ser Ser His Leu Thr Ala Cys Gly Gly Arg Gly Lys Arg Ser Leu 
                245                 250                 255     


Asp 
    


<210>  7387
<211>  307
<212>  PRT
<213>  Homo Sapiens

<400>  7387

Met Gly Gly Leu Arg Pro Trp Ser Arg Tyr Gly Leu Leu Val Val Ala 
1               5                   10                  15      


His Leu Leu Ala Leu Gly Leu Gly Ala Val Val Phe Gln Ala Leu Glu 
            20                  25                  30          


Gly Pro Pro Ala Cys Arg Leu Gln Ala Glu Leu Arg Ala Glu Leu Ala 
        35                  40                  45              


Ala Phe Gln Ala Glu His Arg Ala Cys Leu Pro Pro Gly Ala Leu Glu 
    50                  55                  60                  


Glu Leu Leu Gly Thr Ala Leu Ala Thr Gln Ala His Gly Val Ser Thr 
65                  70                  75                  80  


Leu Gly Asn Ser Ser Glu Gly Arg Thr Trp Asp Leu Pro Ser Ala Leu 
                85                  90                  95      


Leu Phe Ala Ala Ser Ile Leu Thr Thr Thr Gly Tyr Gly His Met Ala 
            100                 105                 110         


Pro Leu Ser Pro Gly Gly Lys Ala Phe Cys Met Val Tyr Ala Ala Leu 
        115                 120                 125             


Gly Leu Pro Ala Ser Leu Ala Leu Val Ala Thr Leu Arg His Cys Leu 
    130                 135                 140                 


Leu Pro Val Leu Ser Arg Pro Arg Ala Trp Val Ala Val His Trp Gln 
145                 150                 155                 160 


Leu Ser Pro Ala Arg Ala Ala Leu Leu Gln Ala Val Ala Leu Gly Leu 
                165                 170                 175     


Leu Val Ala Ser Ser Phe Val Leu Leu Pro Ala Leu Val Leu Trp Gly 
            180                 185                 190         


Leu Gln Gly Asp Cys Ser Leu Leu Gly Ala Val Tyr Phe Cys Phe Ser 
        195                 200                 205             


Ser Leu Ser Thr Ile Gly Leu Glu Asp Leu Leu Pro Gly Arg Gly Arg 
    210                 215                 220                 


Ser Leu His Pro Val Ile Tyr His Leu Gly Gln Leu Ala Leu Leu Gly 
225                 230                 235                 240 


Tyr Leu Leu Leu Gly Leu Leu Ala Met Leu Leu Ala Val Glu Thr Phe 
                245                 250                 255     


Ser Glu Leu Pro Gln Val Arg Ala Met Gly Lys Phe Phe Arg Pro Ser 
            260                 265                 270         


Gly Pro Val Thr Ala Glu Asp Gln Gly Gly Ile Leu Gly Gln Asp Glu 
        275                 280                 285             


Leu Ala Leu Ser Thr Leu Pro Pro Ala Ala Pro Ala Ser Gly Gln Ala 
    290                 295                 300                 


Pro Ala Cys 
305         


<210>  7388
<211>  72
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7388

Xaa His Leu Gly Gln Leu Ala Leu Leu Gly Leu Leu Ala Met Leu Leu 
1               5                   10                  15      


Ala Val Glu Thr Phe Ser Glu Leu Pro Gln Val Arg Ala Met Gly Lys 
            20                  25                  30          


Phe Phe Arg Pro Ser Gly Pro Val Thr Ala Glu Asp Gln Gly Gly Ile 
        35                  40                  45              


Leu Gly Gln Asp Glu Leu Ala Leu Ser Thr Leu Pro Pro Ala Ala Pro 
    50                  55                  60                  


Ala Ser Gly Gln Ala Pro Ala Cys 
65                  70          


<210>  7389
<211>  28
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7389

Xaa Leu His Pro Val Ile Tyr His Leu Gly Gln Leu Ala Leu Leu Gly 
1               5                   10                  15      


Gly Gly Thr Ser Leu Gln Gly Thr Ala Trp Glu Gly 
            20                  25              


<210>  7390
<211>  57
<212>  PRT
<213>  Homo Sapiens

<400>  7390

Met Gly Gly Asp Leu Val Leu Gly Leu Gly Ala Leu Arg Arg Arg Lys 
1               5                   10                  15      


Arg Leu Leu Glu Gln Glu Lys Ser Leu Ala Gly Trp Ala Leu Val Leu 
            20                  25                  30          


Ala Gly Thr Gly Ile Gly Leu Met Val Leu His Ala Glu Met Leu Trp 
        35                  40                  45              


Phe Gly Gly Cys Ser Thr His Phe Gly 
    50                  55          


<210>  7391
<211>  427
<212>  PRT
<213>  Homo Sapiens

<400>  7391

Met Gly Gly Asp Leu Val Leu Gly Leu Gly Ala Leu Arg Arg Arg Lys 
1               5                   10                  15      


Arg Leu Leu Glu Gln Glu Lys Ser Leu Ala Gly Trp Ala Leu Val Leu 
            20                  25                  30          


Ala Gly Thr Gly Ile Gly Leu Met Val Leu His Ala Glu Met Leu Trp 
        35                  40                  45              


Phe Gly Gly Cys Ser Trp Ala Leu Tyr Leu Phe Leu Val Lys Cys Thr 
    50                  55                  60                  


Ile Ser Ile Ser Thr Phe Leu Leu Leu Cys Leu Ile Val Ala Phe His 
65                  70                  75                  80  


Ala Lys Glu Val Gln Leu Phe Met Thr Asp Asn Gly Leu Arg Asp Trp 
                85                  90                  95      


Arg Val Ala Leu Thr Gly Arg Gln Ala Ala Gln Ile Val Leu Glu Leu 
            100                 105                 110         


Val Val Cys Gly Leu His Pro Ala Pro Val Arg Gly Pro Pro Cys Val 
        115                 120                 125             


Gln Asp Leu Gly Ala Pro Leu Thr Ser Pro Gln Pro Trp Pro Gly Phe 
    130                 135                 140                 


Leu Gly Gln Gly Glu Ala Leu Leu Ser Leu Ala Met Leu Leu Arg Leu 
145                 150                 155                 160 


Tyr Leu Val Pro Arg Ala Val Leu Leu Arg Ser Gly Val Leu Leu Asn 
                165                 170                 175     


Ala Ser Tyr Arg Ser Ile Gly Ala Leu Asn Gln Val Arg Phe Arg His 
            180                 185                 190         


Trp Phe Val Ala Lys Leu Tyr Met Asn Thr His Pro Gly Arg Leu Leu 
        195                 200                 205             


Leu Gly Leu Thr Leu Gly Leu Trp Leu Thr Thr Ala Trp Val Leu Ser 
    210                 215                 220                 


Val Ala Glu Arg Gln Ala Val Asn Ala Thr Gly His Leu Ser Asp Thr 
225                 230                 235                 240 


Leu Trp Leu Ile Pro Ile Thr Phe Leu Thr Ile Gly Tyr Gly Asp Val 
                245                 250                 255     


Val Pro Gly Thr Met Trp Gly Lys Ile Val Cys Leu Cys Thr Gly Val 
            260                 265                 270         


Met Gly Val Cys Cys Thr Ala Leu Leu Val Ala Val Val Ala Arg Lys 
        275                 280                 285             


Leu Glu Phe Asn Lys Ala Glu Lys His Val His Asn Phe Met Met Asp 
    290                 295                 300                 


Ile Gln Tyr Thr Lys Glu Met Lys Glu Ser Ala Ala Arg Val Leu Gln 
305                 310                 315                 320 


Glu Ala Trp Met Phe Tyr Lys His Thr Arg Arg Lys Glu Ser His Ala 
                325                 330                 335     


Ala Arg Arg His Gln Arg Lys Leu Leu Ala Ala Ile Asn Ala Phe Arg 
            340                 345                 350         


Gln Val Arg Leu Lys His Arg Lys Leu Arg Glu Gln Val Asn Ser Met 
        355                 360                 365             


Val Asp Ile Ser Lys Met His Met Ile Leu Tyr Asp Leu Gln Gln Asn 
    370                 375                 380                 


Leu Ser Ser Ser His Arg Ala Leu Glu Lys Gln Ile Asp Thr Leu Ala 
385                 390                 395                 400 


Gly Lys Leu Asp Ala Leu Thr Glu Leu Leu Ser Thr Ala Leu Gly Pro 
                405                 410                 415     


Arg Gln Leu Pro Glu Pro Ser Gln Gln Ser Lys 
            420                 425         


<210>  7392
<211>  295
<212>  PRT
<213>  Homo Sapiens

<400>  7392

Met His Asp Gln His Phe His Leu Leu Thr Pro Leu Pro His Arg Gly 
1               5                   10                  15      


Leu Ser Cys Gln Arg Gly Pro Ala Val His Asp Arg Gln Arg Ala Ala 
            20                  25                  30          


Gly Leu Ala Arg Gly Ala Asp Arg Ala Ala Gly Asn Ala Ser Tyr Arg 
        35                  40                  45              


Ser Ile Gly Ala Leu Asn Gln Val Arg Phe Arg His Trp Phe Val Ala 
    50                  55                  60                  


Lys Leu Tyr Met Asn Thr His Pro Gly Arg Leu Leu Leu Gly Leu Thr 
65                  70                  75                  80  


Leu Gly Leu Trp Leu Thr Thr Ala Trp Val Leu Ser Val Ala Glu Arg 
                85                  90                  95      


Gln Ala Val Asn Ala Thr Gly His Leu Ser Asp Thr Leu Trp Leu Ile 
            100                 105                 110         


Pro Ile Thr Phe Leu Thr Ile Gly Tyr Gly Asp Val Val Pro Gly Thr 
        115                 120                 125             


Met Trp Gly Lys Ile Val Cys Leu Cys Thr Gly Val Met Gly Val Cys 
    130                 135                 140                 


Cys Thr Ala Leu Leu Val Ala Val Val Ala Arg Lys Leu Glu Phe Asn 
145                 150                 155                 160 


Lys Ala Glu Lys His Val His Asn Phe Met Met Asp Ile Gln Tyr Thr 
                165                 170                 175     


Lys Glu Met Lys Glu Ser Ala Ala Arg Val Leu Gln Glu Ala Trp Met 
            180                 185                 190         


Phe Tyr Lys His Thr Arg Arg Lys Glu Ser His Ala Ala Arg Arg His 
        195                 200                 205             


Gln Arg Lys Leu Leu Ala Ala Ile Asn Ala Phe Arg Gln Val Arg Leu 
    210                 215                 220                 


Lys His Arg Lys Leu Arg Glu Gln Val Asn Ser Met Val Asp Ile Ser 
225                 230                 235                 240 


Lys Met His Met Ile Leu Tyr Asp Leu Gln Gln Asn Leu Ser Ser Ser 
                245                 250                 255     


His Arg Ala Leu Glu Lys Gln Ile Asp Thr Leu Ala Gly Lys Leu Asp 
            260                 265                 270         


Ala Leu Thr Glu Leu Leu Ser Thr Ala Leu Gly Pro Arg Gln Leu Pro 
        275                 280                 285             


Glu Pro Ser Gln Gln Ser Lys 
    290                 295 


<210>  7393
<211>  113
<212>  PRT
<213>  Homo Sapiens

<400>  7393

Ser Asp Thr Leu Trp Leu Ile Pro Ile Thr Phe Leu Thr Ile Gly Tyr 
1               5                   10                  15      


Gly Asp Val Val Pro Gly Thr Met Trp Gly Lys Ile Val Cys Leu Cys 
            20                  25                  30          


Thr Gly Val Met Gly Val Cys Cys Thr Ala Leu Leu Val Ala Val Val 
        35                  40                  45              


Ala Arg Lys Leu Glu Phe Asn Lys Ala Glu Lys His Val His Asn Phe 
    50                  55                  60                  


Met Met Asp Ile Gln Tyr Thr Lys Glu Met Lys Glu Ser Ala Ala Arg 
65                  70                  75                  80  


Val Leu Gln Glu Ala Trp Met Phe Tyr Lys His Thr Arg Arg Lys Glu 
                85                  90                  95      


Ser His Ala Ala Arg Arg His Gln Arg Lys Leu Leu Ala Ala Ile Asn 
            100                 105                 110         


Ala 
    


<210>  7394
<211>  59
<212>  PRT
<213>  Homo Sapiens

<400>  7394

Val Asp Ile Ser Lys Met His Met Ile Leu Tyr Asp Leu Gln Gln Asn 
1               5                   10                  15      


Leu Ser Ser Ser His Arg Ala Leu Glu Lys Gln Ile Asp Thr Leu Ala 
            20                  25                  30          


Gly Lys Leu Asp Ala Leu Thr Glu Leu Leu Ser Thr Ala Leu Gly Pro 
        35                  40                  45              


Arg Gln Leu Pro Glu Pro Ser Gln Gln Ser Lys 
    50                  55                  


<210>  7395
<211>  165
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7395

Xaa Val Cys Cys Thr Ala Leu Leu Val Ala Val Val Ala Arg Lys Leu 
1               5                   10                  15      


Glu Phe Asn Lys Ala Glu Lys His Val His Asn Phe Met Met Asp Ile 
            20                  25                  30          


Gln Tyr Thr Lys Glu Glu Gly Val Ser Cys Cys Pro Gln Ala Ser Ala 
        35                  40                  45              


Gln Ala Ala Gly Arg His Gln Arg Val Arg Ala Ala Leu Tyr Ala His 
    50                  55                  60                  


Val Ser Met Cys Thr His Val Gln Val Thr Ser Leu His Gly Cys Val 
65                  70                  75                  80  


Cys Ala Cys Pro Cys Leu Ser Arg Phe Arg Gln Val Arg Leu Lys His 
                85                  90                  95      


Arg Lys Leu Arg Glu Gln Val Asn Ser Met Val Asp Ile Ser Lys Met 
            100                 105                 110         


His Met Ile Leu Tyr Asp Leu Gln Gln Asn Leu Ser Ser Ser His Arg 
        115                 120                 125             


Ala Leu Glu Lys Gln Ile Asp Thr Leu Ala Gly Lys Leu Asp Ala Leu 
    130                 135                 140                 


Thr Glu Leu Leu Ser Thr Ala Leu Gly Pro Arg Gln Leu Pro Glu Pro 
145                 150                 155                 160 


Ser Gln Gln Ser Lys 
                165 


<210>  7396
<211>  113
<212>  PRT
<213>  Homo Sapiens

<400>  7396

Met Phe Gln Thr Lys Leu Arg Asn Glu Thr Trp Glu Asp Leu Pro Lys 
1               5                   10                  15      


Met Ser Cys Thr Thr Glu Ile Gln Ala Ala Phe Ile Leu Ser Ser Phe 
            20                  25                  30          


Val Thr Phe Phe Ser Gly Leu Ile Ile Leu Leu Ile Phe Arg Leu Ile 
        35                  40                  45              


Trp Arg Ser Val Lys Lys Trp Gln Ile Ile Lys Gly Thr Gly Ile Ile 
    50                  55                  60                  


Leu Glu Leu Phe Thr Ser Gly Thr Ile Ala Arg Ser His Val Arg Ser 
65                  70                  75                  80  


Leu His Phe Gln Gly Gln Phe Arg Asp His Ile Glu Met Leu Leu Ser 
                85                  90                  95      


Ala Gln Thr Phe Val Gly Gln Val Leu Pro Cys Trp Lys Leu Phe Ile 
            100                 105                 110         


Ile 
    


<210>  7397
<211>  1149
<212>  PRT
<213>  Homo Sapiens

<400>  7397

Met Phe Gln Thr Lys Leu Arg Asn Glu Thr Trp Glu Asp Leu Pro Lys 
1               5                   10                  15      


Met Ser Cys Thr Thr Glu Ile Gln Ala Ala Phe Ile Leu Ser Ser Phe 
            20                  25                  30          


Val Thr Phe Phe Ser Gly Leu Ile Ile Leu Leu Ile Phe Arg Leu Ile 
        35                  40                  45              


Trp Arg Ser Val Lys Lys Trp Gln Ile Ile Lys Gly Thr Gly Ile Ile 
    50                  55                  60                  


Leu Glu Leu Phe Thr Ser Gly Thr Ile Ala Arg Ser His Val Arg Ser 
65                  70                  75                  80  


Leu His Phe Gln Gly Gln Phe Arg Asp His Ile Glu Met Leu Leu Ser 
                85                  90                  95      


Ala Gln Thr Phe Val Gly Gln Val Leu Val Ile Leu Val Phe Val Leu 
            100                 105                 110         


Ser Ile Gly Ser Leu Ile Ile Tyr Phe Ile Asn Ser Ala Asp Pro Val 
        115                 120                 125             


Gly Ser Cys Ser Ser Tyr Glu Asp Lys Thr Ile Pro Ile Asp Leu Val 
    130                 135                 140                 


Phe Asn Ala Phe Phe Ser Phe Tyr Phe Gly Leu Arg Phe Met Ala Ala 
145                 150                 155                 160 


Asp Asp Lys Ile Lys Phe Trp Leu Glu Met Asn Ser Ile Val Asp Ile 
                165                 170                 175     


Phe Thr Ile Pro Pro Thr Phe Ile Ser Tyr Tyr Leu Lys Ser Asn Trp 
            180                 185                 190         


Leu Gly Leu Arg Phe Leu Arg Ala Leu Arg Leu Leu Glu Leu Pro Gln 
        195                 200                 205             


Ile Leu Gln Ile Leu Arg Ala Ile Lys Thr Ser Asn Ser Val Lys Phe 
    210                 215                 220                 


Ser Lys Leu Leu Ser Ile Ile Leu Ser Thr Trp Phe Thr Ala Ala Gly 
225                 230                 235                 240 


Phe Ile His Leu Val Glu Asn Ser Gly Asp Pro Trp Leu Lys Gly Arg 
                245                 250                 255     


Asn Ser Gln Asn Ile Ser Tyr Phe Glu Ser Ile Tyr Leu Val Met Ala 
            260                 265                 270         


Thr Thr Ser Thr Val Gly Phe Gly Asp Val Val Ala Lys Thr Ser Leu 
        275                 280                 285             


Gly Arg Thr Phe Ile Met Phe Phe Thr Leu Gly Ser Leu Ile Leu Phe 
    290                 295                 300                 


Ala Asn Tyr Ile Pro Glu Met Val Glu Leu Phe Ala Asn Lys Arg Lys 
305                 310                 315                 320 


Tyr Thr Ser Ser Tyr Glu Ala Leu Lys Gly Lys Lys Phe Ile Val Val 
                325                 330                 335     


Cys Gly Asn Ile Thr Val Asp Ser Val Thr Ala Phe Leu Arg Asn Phe 
            340                 345                 350         


Leu Arg Asp Lys Ser Gly Glu Ile Asn Thr Glu Ile Val Phe Leu Gly 
        355                 360                 365             


Glu Thr Pro Pro Ser Leu Glu Leu Glu Thr Ile Phe Lys Cys Tyr Leu 
    370                 375                 380                 


Ala Tyr Thr Thr Phe Ile Ser Gly Ser Ala Met Lys Trp Glu Asp Leu 
385                 390                 395                 400 


Arg Arg Val Ala Val Glu Ser Ala Glu Ala Cys Leu Ile Ile Ala Asn 
                405                 410                 415     


Pro Leu Cys Ser Asp Ser His Ala Glu Asp Ile Ser Asn Ile Met Arg 
            420                 425                 430         


Val Leu Ser Ile Lys Asn Tyr Asp Ser Thr Thr Arg Ile Ile Ile Gln 
        435                 440                 445             


Ile Leu Gln Ser His Asn Lys Val Tyr Leu Pro Lys Ile Pro Ser Trp 
    450                 455                 460                 


Asn Trp Asp Thr Gly Asp Asn Ile Ile Cys Phe Ala Glu Leu Lys Leu 
465                 470                 475                 480 


Gly Phe Ile Ala Gln Gly Cys Leu Val Pro Gly Leu Cys Thr Phe Leu 
                485                 490                 495     


Thr Ser Leu Phe Val Glu Gln Asn Lys Lys Val Met Pro Lys Gln Thr 
            500                 505                 510         


Trp Lys Lys His Phe Leu Asn Ser Met Lys Asn Lys Ile Leu Thr Gln 
        515                 520                 525             


Arg Leu Ser Asp Asp Phe Ala Gly Met Ser Phe Pro Glu Val Ala Arg 
    530                 535                 540                 


Leu Cys Phe Leu Lys Met His Leu Leu Leu Ile Ala Ile Glu Tyr Lys 
545                 550                 555                 560 


Ser Leu Phe Thr Asp Gly Phe Cys Gly Leu Ile Leu Asn Pro Pro Pro 
                565                 570                 575     


Gln Val Arg Ile Arg Lys Asn Thr Leu Gly Phe Phe Ile Ala Glu Thr 
            580                 585                 590         


Pro Lys Asp Val Arg Arg Ala Leu Phe Tyr Cys Ser Val Cys His Asp 
        595                 600                 605             


Asp Val Phe Ile Pro Glu Leu Ile Thr Asn Cys Gly Cys Lys Ser Arg 
    610                 615                 620                 


Ser Arg Gln His Ile Thr Val Pro Ser Val Lys Arg Met Lys Lys Cys 
625                 630                 635                 640 


Leu Lys Gly Ile Ser Ser Arg Ile Ser Gly Gln Asp Ser Pro Pro Arg 
                645                 650                 655     


Val Ser Ala Ser Thr Ser Ser Ile Ser Asn Phe Thr Thr Arg Thr Leu 
            660                 665                 670         


Gln His Asp Val Glu Gln Asp Ser Asp Gln Leu Asp Ser Ser Gly Met 
        675                 680                 685             


Phe His Trp Cys Lys Pro Thr Ser Leu Asp Lys Val Thr Leu Lys Arg 
    690                 695                 700                 


Thr Gly Lys Ser Lys Tyr Lys Phe Arg Asn His Ile Val Ala Cys Val 
705                 710                 715                 720 


Phe Gly Asp Ala His Ser Ala Pro Met Gly Leu Arg Asn Phe Val Met 
                725                 730                 735     


Pro Leu Arg Ala Ser Asn Tyr Thr Arg Lys Glu Leu Lys Asp Ile Val 
            740                 745                 750         


Phe Ile Gly Ser Leu Asp Tyr Leu Gln Arg Glu Trp Arg Phe Leu Trp 
        755                 760                 765             


Asn Phe Pro Gln Ile Tyr Ile Leu Pro Gly Cys Ala Leu Tyr Ser Gly 
    770                 775                 780                 


Asp Leu His Ala Ala Asn Ile Glu Gln Cys Ser Met Cys Ala Val Leu 
785                 790                 795                 800 


Ser Pro Pro Pro Gln Pro Ser Ser Asn Gln Thr Leu Val Asp Thr Glu 
                805                 810                 815     


Ala Ile Met Ala Thr Leu Thr Ile Gly Ser Leu Gln Ile Asp Ser Ser 
            820                 825                 830         


Ser Asp Pro Ser Pro Ser Val Ser Glu Glu Thr Pro Gly Tyr Thr Asn 
        835                 840                 845             


Gly His Asn Glu Lys Ser Asn Cys Arg Lys Val Pro Ile Leu Thr Glu 
    850                 855                 860                 


Leu Lys Asn Pro Ser Asn Ile His Phe Ile Glu Gln Leu Gly Gly Leu 
865                 870                 875                 880 


Glu Gly Ser Leu Gln Glu Thr Asn Leu His Leu Ser Thr Ala Phe Ser 
                885                 890                 895     


Thr Gly Thr Val Phe Ser Gly Ser Phe Leu Asp Ser Leu Leu Ala Thr 
            900                 905                 910         


Ala Phe Tyr Asn Tyr His Val Leu Glu Leu Leu Gln Met Leu Val Thr 
        915                 920                 925             


Gly Gly Val Ser Ser Gln Leu Glu Gln His Leu Asp Lys Asp Lys Val 
    930                 935                 940                 


Tyr Gly Val Ala Asp Ser Cys Thr Ser Leu Leu Ser Gly Arg Asn Arg 
945                 950                 955                 960 


Cys Lys Leu Gly Leu Leu Ser Leu His Glu Thr Ile Leu Ser Asp Val 
                965                 970                 975     


Asn Pro Arg Asn Thr Phe Gly Gln Leu Phe Cys Gly Ser Leu Asp Leu 
            980                 985                 990         


Phe Gly Ile Leu Cys Val Gly Leu  Tyr Arg Ile Ile Asp  Glu Glu Glu 
        995                 1000                 1005             


Leu Asn  Pro Glu Asn Lys Arg  Phe Val Ile Thr Arg  Pro Ala Asn 
    1010                 1015                 1020             


Glu Phe  Lys Leu Leu Pro Ser  Asp Leu Val Phe Cys  Ala Ile Pro 
    1025                 1030                 1035             


Phe Ser  Thr Ala Cys Tyr Lys  Arg Asn Glu Glu Phe  Ser Leu Gln 
    1040                 1045                 1050             


Lys Ser  Tyr Glu Ile Val Asn  Lys Ala Ser Gln Thr  Thr Glu Thr 
    1055                 1060                 1065             


His Ser  Asp Thr Asn Cys Pro  Pro Thr Ile Asp Ser  Val Thr Glu 
    1070                 1075                 1080             


Thr Leu  Tyr Ser Pro Val Tyr  Ser Tyr Gln Pro Arg  Thr Asn Ser 
    1085                 1090                 1095             


Leu Ser  Phe Pro Lys Gln Ile  Ala Trp Asn Gln Ser  Arg Thr Asn 
    1100                 1105                 1110             


Ser Ile  Ile Ser Ser Gln Ile  Pro Leu Gly Asp Asn  Ala Lys Glu 
    1115                 1120                 1125             


Asn Glu  Arg Lys Thr Ser Asp  Glu Val Tyr Asp Glu  Asp Pro Phe 
    1130                 1135                 1140             


Ala Tyr  Ser Glu Pro Leu 
    1145                 


<210>  7398
<211>  308
<212>  PRT
<213>  Homo Sapiens

<400>  7398

Met Phe Gln Thr Lys Leu Arg Asn Glu Thr Trp Glu Asp Leu Pro Lys 
1               5                   10                  15      


Met Ser Cys Thr Thr Glu Ile Gln Ala Ala Phe Ile Leu Ser Ser Phe 
            20                  25                  30          


Val Thr Phe Phe Ser Gly Leu Ile Ile Leu Leu Ile Phe Arg Leu Ile 
        35                  40                  45              


Trp Arg Ser Val Lys Lys Trp Gln Ile Ile Lys Gly Thr Gly Ile Ile 
    50                  55                  60                  


Leu Glu Leu Phe Thr Ser Gly Thr Ile Ala Arg Ser His Val Arg Ser 
65                  70                  75                  80  


Leu His Phe Gln Gly Gln Phe Arg Asp His Ile Glu Met Leu Leu Ser 
                85                  90                  95      


Ala Gln Thr Phe Val Gly Gln Val Leu Val Ile Leu Val Phe Val Leu 
            100                 105                 110         


Ser Ile Gly Ser Leu Ile Ile Tyr Phe Ile Asn Ser Ala Asp Pro Val 
        115                 120                 125             


Gly Ser Cys Ser Ser Tyr Glu Asp Lys Thr Ile Pro Ile Asp Leu Val 
    130                 135                 140                 


Phe Asn Ala Phe Phe Ser Phe Tyr Phe Gly Leu Arg Phe Met Ala Ala 
145                 150                 155                 160 


Asp Asp Lys Ile Lys Phe Trp Leu Glu Met Asn Ser Ile Val Asp Ile 
                165                 170                 175     


Phe Thr Ile Pro Pro Thr Phe Ile Ser Tyr Tyr Leu Lys Ser Asn Trp 
            180                 185                 190         


Leu Gly Leu Arg Phe Leu Arg Ala Leu Arg Leu Leu Glu Leu Pro Gln 
        195                 200                 205             


Ile Leu Gln Ile Leu Arg Ala Ile Lys Thr Ser Asn Ser Val Lys Phe 
    210                 215                 220                 


Ser Lys Leu Leu Ser Ile Ile Leu Ser Thr Trp Phe Thr Ala Ala Gly 
225                 230                 235                 240 


Phe Ile His Leu Val Glu Asn Ser Gly Asp Pro Trp Leu Lys Gly Arg 
                245                 250                 255     


Asn Ser Gln Asn Ile Ser Tyr Phe Glu Ser Ile Tyr Leu Val Met Ala 
            260                 265                 270         


Thr Thr Ser Thr Val Gly Phe Gly Asp Val Val Ala Lys Thr Ser Leu 
        275                 280                 285             


Gly Arg Thr Phe Ile Met Phe Phe Thr Leu Gly Ser Leu Val Lys Asn 
    290                 295                 300                 


Ile Phe Asn Ile 
305             


<210>  7399
<211>  947
<212>  PRT
<213>  Homo Sapiens

<400>  7399

Met Phe Gln Thr Lys Leu Arg Asn Glu Thr Trp Glu Asp Leu Pro Lys 
1               5                   10                  15      


Met Ser Cys Thr Thr Glu Ile Gln Ala Ala Phe Ile Leu Ser Ser Phe 
            20                  25                  30          


Val Thr Phe Phe Ser Gly Leu Ile Ile Leu Leu Ile Phe Arg Leu Ile 
        35                  40                  45              


Trp Arg Ser Val Lys Lys Trp Gln Ile Ile Lys Gly Thr Gly Ile Ile 
    50                  55                  60                  


Leu Glu Leu Phe Thr Ser Gly Thr Ile Ala Arg Ser His Val Arg Ser 
65                  70                  75                  80  


Leu His Phe Gln Gly Gln Phe Arg Asp His Ile Glu Met Leu Leu Ser 
                85                  90                  95      


Ala Gln Thr Phe Val Gly Gln Val Leu Val Ile Leu Val Phe Val Leu 
            100                 105                 110         


Ser Ile Gly Ser Leu Ile Ile Tyr Phe Ile Asn Ser Ala Asp Pro Val 
        115                 120                 125             


Gly Ser Cys Ser Ser Tyr Glu Asp Lys Thr Ile Pro Ile Asp Leu Val 
    130                 135                 140                 


Phe Asn Ala Phe Phe Ser Phe Tyr Phe Gly Leu Arg Phe Met Ala Ala 
145                 150                 155                 160 


Asp Asp Lys Ile Lys Phe Trp Leu Glu Met Asn Ser Ile Val Asp Ile 
                165                 170                 175     


Phe Thr Ile Pro Pro Thr Phe Ile Ser Tyr Tyr Leu Lys Ser Asn Trp 
            180                 185                 190         


Leu Gly Leu Arg Phe Leu Arg Ala Leu Arg Leu Leu Glu Leu Pro Gln 
        195                 200                 205             


Ile Leu Gln Ile Leu Arg Ala Ile Lys Thr Ser Asn Ser Val Lys Phe 
    210                 215                 220                 


Ser Lys Leu Leu Ser Ile Ile Leu Ser Thr Trp Phe Thr Ala Ala Gly 
225                 230                 235                 240 


Phe Ile His Leu Val Glu Asn Ser Gly Asp Pro Trp Leu Lys Gly Arg 
                245                 250                 255     


Asn Ser Gln Asn Ile Ser Tyr Phe Glu Ser Ile Tyr Leu Val Met Ala 
            260                 265                 270         


Thr Thr Ser Thr Val Gly Phe Gly Asp Val Val Ala Lys Thr Ser Leu 
        275                 280                 285             


Gly Arg Thr Phe Ile Met Phe Phe Thr Leu Gly Ser Leu Ile Leu Phe 
    290                 295                 300                 


Ala Asn Tyr Ile Pro Glu Met Val Glu Leu Phe Ala Asn Lys Arg Lys 
305                 310                 315                 320 


Tyr Thr Ser Ser Tyr Glu Ala Leu Lys Gly Lys Lys Phe Ile Val Val 
                325                 330                 335     


Cys Gly Asn Ile Thr Val Asp Ser Val Thr Ala Phe Leu Arg Asn Phe 
            340                 345                 350         


Leu Arg Asp Lys Ser Gly Glu Ile Asn Thr Glu Ile Val Phe Leu Gly 
        355                 360                 365             


Glu Thr Pro Pro Ser Leu Glu Leu Glu Thr Ile Phe Lys Cys Tyr Leu 
    370                 375                 380                 


Ala Tyr Thr Thr Phe Ile Ser Gly Ser Ala Met Lys Trp Glu Asp Leu 
385                 390                 395                 400 


Arg Arg Val Ala Val Glu Ser Ala Glu Ala Cys Leu Ile Ile Ala Asn 
                405                 410                 415     


Pro Leu Cys Ser Asp Ser His Ala Glu Asp Ile Ser Asn Ile Met Arg 
            420                 425                 430         


Val Leu Ser Ile Lys Asn Tyr Asp Ser Thr Thr Arg Ile Ile Ile Gln 
        435                 440                 445             


Ile Leu Gln Ser His Asn Lys Val Tyr Leu Pro Lys Ile Pro Ser Trp 
    450                 455                 460                 


Asn Trp Asp Thr Gly Asp Asn Ile Ile Cys Phe Ala Glu Leu Lys Leu 
465                 470                 475                 480 


Gly Phe Ile Ala Gln Gly Cys Leu Val Pro Gly Leu Cys Thr Phe Leu 
                485                 490                 495     


Thr Ser Leu Phe Val Glu Gln Asn Lys Lys Val Met Pro Lys Gln Thr 
            500                 505                 510         


Trp Lys Lys His Phe Leu Asn Ser Met Lys Asn Lys Ile Leu Thr Gln 
        515                 520                 525             


Arg Leu Ser Asp Asp Phe Ala Gly Met Ser Phe Pro Glu Val Ala Arg 
    530                 535                 540                 


Leu Cys Phe Leu Lys Met His Leu Leu Leu Ile Ala Ile Glu Tyr Lys 
545                 550                 555                 560 


Ser Leu Phe Thr Asp Gly Phe Cys Gly Leu Ile Leu Asn Pro Pro Pro 
                565                 570                 575     


Gln Val Arg Ile Arg Lys Asn Thr Leu Gly Phe Phe Ile Ala Glu Thr 
            580                 585                 590         


Pro Lys Asp Val Arg Arg Ala Leu Phe Tyr Cys Ser Val Cys His Asp 
        595                 600                 605             


Asp Val Phe Ile Pro Glu Leu Ile Thr Asn Cys Gly Cys Lys Ser Arg 
    610                 615                 620                 


Ser Arg Gln His Ile Thr Val Pro Ser Val Lys Arg Met Lys Lys Cys 
625                 630                 635                 640 


Leu Lys Gly Ile Ser Ser Arg Ile Ser Gly Gln Asp Ser Pro Pro Arg 
                645                 650                 655     


Val Ser Ala Ser Thr Ser Ser Ile Ser Asn Phe Thr Thr Arg Thr Leu 
            660                 665                 670         


Gln His Asp Val Glu Gln Asp Ser Asp Gln Leu Asp Ser Ser Gly Met 
        675                 680                 685             


Phe His Trp Cys Lys Pro Thr Ser Leu Asp Lys Val Thr Leu Lys Arg 
    690                 695                 700                 


Thr Gly Lys Ser Lys Tyr Lys Phe Arg Asn His Ile Val Ala Cys Val 
705                 710                 715                 720 


Phe Gly Asp Ala His Ser Ala Pro Met Gly Leu Arg Asn Phe Val Met 
                725                 730                 735     


Pro Leu Arg Ala Ser Asn Tyr Thr Arg Lys Glu Leu Lys Asp Ile Val 
            740                 745                 750         


Phe Ile Gly Ser Leu Asp Tyr Leu Gln Arg Glu Trp Arg Phe Leu Trp 
        755                 760                 765             


Asn Phe Pro Gln Ile Tyr Ile Leu Pro Gly Cys Ala Leu Tyr Ser Gly 
    770                 775                 780                 


Asp Leu His Ala Ala Asn Ile Glu Gln Cys Ser Met Cys Ala Val Leu 
785                 790                 795                 800 


Ser Pro Pro Pro Gln Pro Ser Ser Asn Gln Thr Leu Val Asp Thr Glu 
                805                 810                 815     


Ala Ile Met Ala Thr Leu Thr Ile Gly Ser Leu Gln Ile Asp Ser Ser 
            820                 825                 830         


Ser Asp Pro Ser Pro Ser Val Ser Glu Glu Thr Pro Gly Tyr Thr Asn 
        835                 840                 845             


Gly His Asn Glu Lys Ser Asn Cys Arg Lys Val Pro Ile Leu Thr Glu 
    850                 855                 860                 


Leu Lys Asn Pro Ser Asn Ile His Phe Ile Glu Gln Leu Gly Gly Leu 
865                 870                 875                 880 


Glu Gly Ser Leu Gln Glu Thr Asn Leu His Leu Ser Thr Ala Phe Ser 
                885                 890                 895     


Thr Gly Thr Val Phe Ser Gly Ser Phe Leu Asp Ser Leu Leu Ala Thr 
            900                 905                 910         


Leu Met Trp Lys Leu Ala Ile Lys Gly Ser Gln Phe Gln Gly Arg Ser 
        915                 920                 925             


Ser Gly Leu Cys Trp Pro Ser Thr Ile Ile Met Ser Trp Asn Cys Phe 
    930                 935                 940                 


Arg Cys Trp 
945         


<210>  7400
<211>  51
<212>  PRT
<213>  Homo Sapiens

<400>  7400

Met Ile Lys Lys Thr Glu Phe Ser Asn Val Cys Ser Ile Phe Tyr Leu 
1               5                   10                  15      


Ile Leu Gln Ala Met Leu Lys Gly Leu Leu Gln Leu Ser Cys Pro Gly 
            20                  25                  30          


Ile Ala Ser Asp Ala Gly Asp Arg Arg Ser Lys Phe Ser Ala Gly Thr 
        35                  40                  45              


Thr Phe Arg 
    50      


<210>  7401
<211>  1628
<212>  PRT
<213>  Homo Sapiens

<400>  7401

Met Ala Gly Val Gly Ala Ala Ala Leu Ser Leu Leu Leu His Leu Gly 
1               5                   10                  15      


Ala Leu Ala Leu Ala Ala Gly Ala Glu Gly Gly Ala Val Pro Arg Glu 
            20                  25                  30          


Pro Pro Gly Gln Gln Thr Thr Ala His Ser Ser Val Leu Ala Gly Asn 
        35                  40                  45              


Ser Gln Glu Gln Trp His Pro Leu Arg Glu Trp Leu Gly Arg Leu Glu 
    50                  55                  60                  


Ala Ala Val Met Glu Leu Arg Glu Gln Asn Lys Asp Leu Gln Thr Arg 
65                  70                  75                  80  


Val Arg Gln Leu Glu Ser Cys Glu Cys His Pro Ala Ser Pro Gln Cys 
                85                  90                  95      


Trp Gly Leu Gly Arg Ala Trp Pro Glu Gly Ala Arg Trp Glu Pro Asp 
            100                 105                 110         


Ala Cys Thr Ala Cys Val Cys Gln Asp Gly Ala Ala His Cys Gly Pro 
        115                 120                 125             


Gln Ala His Leu Pro His Cys Arg Gly Cys Ser Gln Asn Gly Gln Thr 
    130                 135                 140                 


Tyr Gly Asn Gly Glu Thr Phe Ser Pro Asp Ala Cys Thr Thr Cys Arg 
145                 150                 155                 160 


Cys Leu Glu Gly Thr Ile Thr Cys Asn Gln Lys Pro Cys Pro Arg Gly 
                165                 170                 175     


Pro Cys Pro Glu Pro Gly Ala Cys Cys Pro His Cys Lys Pro Gly Cys 
            180                 185                 190         


Asp Tyr Glu Gly Gln Leu Tyr Glu Glu Gly Val Thr Phe Leu Ser Ser 
        195                 200                 205             


Ser Asn Pro Cys Leu Gln Cys Thr Cys Leu Arg Ser Arg Val Arg Cys 
    210                 215                 220                 


Met Ala Leu Lys Cys Pro Pro Ser Pro Cys Pro Glu Pro Val Leu Arg 
225                 230                 235                 240 


Pro Gly His Cys Cys Pro Thr Cys Gln Gly Cys Thr Glu Gly Gly Ser 
                245                 250                 255     


His Trp Glu His Gly Gln Glu Trp Thr Thr Pro Gly Asp Pro Cys Arg 
            260                 265                 270         


Ile Cys Arg Cys Leu Glu Gly His Ile Gln Cys Arg Gln Arg Glu Cys 
        275                 280                 285             


Ala Ser Leu Cys Pro Tyr Pro Ala Arg Pro Leu Pro Gly Thr Cys Cys 
    290                 295                 300                 


Pro Val Cys Asp Gly Cys Phe Leu Asn Gly Arg Glu His Arg Ser Gly 
305                 310                 315                 320 


Glu Pro Val Gly Ser Gly Asp Pro Cys Ser His Cys Arg Cys Ala Asn 
                325                 330                 335     


Gly Ser Val Gln Cys Glu Pro Leu Pro Cys Pro Pro Val Pro Cys Arg 
            340                 345                 350         


His Pro Gly Lys Ile Pro Gly Gln Cys Cys Pro Val Cys Asp Gly Cys 
        355                 360                 365             


Glu Tyr Gln Gly His Gln Tyr Gln Ser Gln Glu Thr Phe Arg Leu Gln 
    370                 375                 380                 


Glu Arg Gly Leu Cys Val Arg Cys Ser Cys Gln Ala Gly Glu Val Ser 
385                 390                 395                 400 


Cys Glu Glu Gln Glu Cys Pro Val Thr Pro Cys Ala Leu Pro Ala Ser 
                405                 410                 415     


Gly Arg Gln Leu Cys Pro Ala Cys Glu Leu Asp Gly Glu Glu Phe Ala 
            420                 425                 430         


Glu Gly Val Gln Trp Glu Pro Asp Gly Arg Pro Cys Thr Ala Cys Val 
        435                 440                 445             


Cys Gln Asp Gly Val Pro Lys Cys Gly Ala Val Leu Cys Pro Pro Ala 
    450                 455                 460                 


Pro Cys Gln His Pro Thr Gln Pro Pro Gly Ala Cys Cys Pro Ser Cys 
465                 470                 475                 480 


Asp Ser Cys Thr Tyr His Ser Gln Val Tyr Ala Asn Gly Gln Asn Phe 
                485                 490                 495     


Thr Asp Ala Asp Ser Pro Cys His Ala Cys His Cys Gln Asp Gly Thr 
            500                 505                 510         


Val Thr Cys Ser Leu Val Asp Cys Pro Pro Thr Thr Cys Ala Arg Pro 
        515                 520                 525             


Gln Ser Gly Pro Gly Gln Cys Cys Pro Arg Cys Pro Asp Cys Ile Leu 
    530                 535                 540                 


Glu Glu Glu Val Phe Val Asp Gly Glu Ser Phe Ser His Pro Arg Asp 
545                 550                 555                 560 


Pro Cys Gln Glu Cys Arg Cys Gln Glu Gly His Ala His Cys Gln Pro 
                565                 570                 575     


Arg Pro Cys Pro Arg Ala Pro Cys Ala His Pro Leu Pro Gly Thr Cys 
            580                 585                 590         


Cys Pro Asn Asp Cys Ser Gly Cys Ala Phe Gly Gly Lys Glu Tyr Pro 
        595                 600                 605             


Ser Gly Ala Asp Phe Pro His Pro Ser Asp Pro Cys Arg Leu Cys Arg 
    610                 615                 620                 


Cys Leu Ser Gly Asn Val Gln Cys Leu Ala Arg Arg Cys Val Pro Leu 
625                 630                 635                 640 


Pro Cys Pro Glu Pro Val Leu Leu Pro Gly Glu Cys Cys Pro Gln Cys 
                645                 650                 655     


Pro Ala Ala Pro Ala Pro Ala Gly Cys Pro Arg Pro Gly Ala Ala His 
            660                 665                 670         


Ala Arg His Gln Glu Tyr Phe Ser Pro Pro Gly Asp Pro Cys Arg Arg 
        675                 680                 685             


Cys Leu Cys Leu Asp Gly Ser Val Ser Cys Gln Arg Leu Pro Cys Pro 
    690                 695                 700                 


Pro Ala Pro Cys Ala His Pro Arg Gln Gly Pro Cys Cys Pro Ser Cys 
705                 710                 715                 720 


Asp Gly Cys Leu Tyr Gln Gly Lys Glu Phe Ala Ser Gly Glu Arg Phe 
                725                 730                 735     


Pro Ser Pro Thr Ala Ala Cys His Leu Cys Leu Cys Trp Glu Gly Ser 
            740                 745                 750         


Val Ser Cys Glu Pro Lys Ala Cys Ala Pro Ala Leu Cys Pro Phe Pro 
        755                 760                 765             


Ala Arg Gly Asp Cys Cys Pro Asp Cys Asp Gly Cys Glu Tyr Leu Gly 
    770                 775                 780                 


Glu Ser Tyr Leu Ser Asn Gln Glu Phe Pro Asp Pro Arg Glu Pro Cys 
785                 790                 795                 800 


Asn Leu Cys Thr Cys Leu Gly Gly Phe Val Thr Cys Gly Arg Arg Pro 
                805                 810                 815     


Cys Glu Pro Pro Gly Cys Ser His Pro Leu Ile Pro Ser Gly His Cys 
            820                 825                 830         


Cys Pro Thr Cys Gln Gly Cys Arg Tyr His Gly Val Thr Thr Ala Ser 
        835                 840                 845             


Gly Glu Thr Leu Pro Asp Pro Leu Asp Pro Thr Cys Ser Leu Cys Thr 
    850                 855                 860                 


Cys Gln Glu Gly Ser Met Arg Cys Gln Lys Lys Pro Cys Pro Pro Ala 
865                 870                 875                 880 


Leu Cys Pro His Pro Ser Pro Gly Pro Cys Phe Cys Pro Val Cys His 
                885                 890                 895     


Ser Cys Leu Ser Gln Gly Arg Glu His Gln Asp Gly Glu Glu Phe Glu 
            900                 905                 910         


Gly Pro Ala Gly Ser Cys Glu Trp Cys Arg Cys Gln Ala Gly Gln Val 
        915                 920                 925             


Ser Cys Val Arg Leu Gln Cys Pro Pro Leu Pro Cys Lys Leu Gln Val 
    930                 935                 940                 


Thr Glu Arg Gly Ser Cys Cys Pro Arg Cys Arg Gly Cys Leu Ala His 
945                 950                 955                 960 


Gly Glu Glu His Pro Glu Gly Ser Arg Trp Val Pro Pro Asp Ser Ala 
                965                 970                 975     


Cys Ser Ser Cys Val Cys His Glu Gly Val Val Thr Cys Ala Arg Ile 
            980                 985                 990         


Gln Cys Ile Ser Ser Cys Ala Gln  Pro Arg Gln Gly Pro  His Asp Cys 
        995                 1000                 1005             


Cys Pro  Gln Cys Ser Asp Cys  Glu His Glu Gly Arg  Lys Tyr Glu 
    1010                 1015                 1020             


Pro Gly  Glu Ser Phe Gln Pro  Gly Ala Asp Pro Cys  Glu Val Cys 
    1025                 1030                 1035             


Ile Cys  Glu Pro Gln Pro Glu  Gly Pro Pro Ser Leu  Arg Cys His 
    1040                 1045                 1050             


Arg Arg  Gln Cys Pro Ser Leu  Val Gly Cys Pro Pro  Ser Gln Leu 
    1055                 1060                 1065             


Leu Pro  Pro Gly Pro Gln His  Cys Cys Pro Thr Cys  Ala Glu Ala 
    1070                 1075                 1080             


Leu Ser  Asn Cys Ser Glu Gly  Leu Leu Gly Ser Glu  Leu Ala Pro 
    1085                 1090                 1095             


Pro Asp  Pro Cys Tyr Thr Cys  Gln Cys Gln Asp Leu  Thr Trp Leu 
    1100                 1105                 1110             


Cys Ile  His Gln Ala Cys Pro  Glu Leu Ser Cys Pro  Leu Ser Glu 
    1115                 1120                 1125             


Arg His  Thr Pro Pro Gly Ser  Cys Cys Pro Val Cys  Arg Glu Cys 
    1130                 1135                 1140             


Val Val  Glu Ala Glu Gly Arg  Arg Val Ala Asp Gly  Glu Ser Trp 
    1145                 1150                 1155             


Arg Asp  Pro Ser Asn Ala Cys  Ile Ala Cys Thr Cys  His Arg Gly 
    1160                 1165                 1170             


His Val  Glu Cys His Leu Glu  Glu Cys Gln Ala Leu  Ser Cys Pro 
    1175                 1180                 1185             


His Gly  Trp Ala Lys Val Pro  Gln Ala Asp Ser Cys  Cys Glu Arg 
    1190                 1195                 1200             


Cys Gln  Ala Pro Thr Gln Ser  Cys Val His Gln Gly  Arg Glu Val 
    1205                 1210                 1215             


Ala Ser  Gly Glu Arg Trp Thr  Val Asp Thr Cys Thr  Ser Cys Ser 
    1220                 1225                 1230             


Cys Met  Ala Gly Thr Val Arg  Cys Gln Ser Gln Arg  Cys Ser Pro 
    1235                 1240                 1245             


Leu Ser  Cys Gly Pro Asp Lys  Ala Pro Ala Leu Ser  Pro Gly Ser 
    1250                 1255                 1260             


Cys Cys  Pro Arg Cys Leu Pro  Arg Pro Ala Ser Cys  Met Ala Phe 
    1265                 1270                 1275             


Gly Asp  Pro His Tyr Arg Thr  Phe Asp Gly Arg Leu  Leu His Phe 
    1280                 1285                 1290             


Gln Gly  Ser Cys Ser Tyr Val  Leu Ala Lys Asp Cys  His Ser Gly 
    1295                 1300                 1305             


Asp Phe  Ser Val His Val Thr  Asn Asp Asp Arg Gly  Arg Ser Gly 
    1310                 1315                 1320             


Val Ala  Trp Thr Gln Glu Val  Ala Val Leu Leu Gly  Asp Met Ala 
    1325                 1330                 1335             


Val Arg  Leu Leu Gln Asp Gly  Ala Val Thr Val Asp  Gly His Pro 
    1340                 1345                 1350             


Val Ala  Leu Pro Phe Leu Gln  Glu Pro Leu Leu Tyr  Val Glu Leu 
    1355                 1360                 1365             


Arg Gly  His Thr Val Ile Leu  His Ala Gln Pro Gly  Leu Gln Val 
    1370                 1375                 1380             


Leu Trp  Asp Gly Gln Ser Gln  Val Glu Val Ser Val  Pro Gly Ser 
    1385                 1390                 1395             


Tyr Gln  Gly Arg Thr Cys Gly  Leu Cys Gly Asn Phe  Asn Gly Phe 
    1400                 1405                 1410             


Ala Gln  Asp Asp Leu Gln Gly  Pro Glu Gly Leu Leu  Leu Pro Ser 
    1415                 1420                 1425             


Glu Ala  Ala Phe Gly Asn Ser  Trp Gln Val Ser Glu  Gly Leu Trp 
    1430                 1435                 1440             


Pro Gly  Arg Pro Cys Ser Ala  Gly Arg Glu Val Asp  Pro Cys Arg 
    1445                 1450                 1455             


Ala Ala  Gly Tyr Arg Ala Arg  Arg Glu Ala Asn Ala  Arg Cys Gly 
    1460                 1465                 1470             


Val Leu  Lys Ser Ser Pro Phe  Ser Arg Cys His Ala  Val Val Pro 
    1475                 1480                 1485             


Pro Glu  Pro Phe Phe Ala Ala  Cys Val Tyr Asp Leu  Cys Ala Cys 
    1490                 1495                 1500             


Gly Pro  Gly Ser Ser Ala Asp  Ala Cys Leu Cys Asp  Ala Leu Glu 
    1505                 1510                 1515             


Ala Tyr  Ala Ser His Cys Arg  Gln Ala Gly Val Thr  Pro Thr Trp 
    1520                 1525                 1530             


Arg Gly  Pro Thr Leu Cys Val  Val Gly Cys Pro Leu  Glu Arg Gly 
    1535                 1540                 1545             


Phe Val  Phe Asp Glu Cys Gly  Pro Pro Cys Pro Arg  Thr Cys Phe 
    1550                 1555                 1560             


Asn Gln  His Ile Pro Leu Gly  Glu Leu Ala Ala His  Cys Val Arg 
    1565                 1570                 1575             


Pro Cys  Val Pro Gly Cys Gln  Cys Pro Ala Gly Leu  Val Glu His 
    1580                 1585                 1590             


Glu Ala  His Cys Ile Pro Pro  Glu Ala Cys Pro Gln  Val Leu Leu 
    1595                 1600                 1605             


Thr Gly  Asp Gln Pro Leu Gly  Ala Arg Pro Ser Pro  Ser Arg Glu 
    1610                 1615                 1620             


Pro Gln  Glu Thr Pro 
    1625             


<210>  7402
<211>  1504
<212>  PRT
<213>  Homo Sapiens

<400>  7402

Met Ala Gly Val Gly Ala Ala Ala Leu Ser Leu Leu Leu His Leu Gly 
1               5                   10                  15      


Ala Leu Ala Leu Ala Ala Gly Ala Glu Gly Gly Ala Val Pro Arg Glu 
            20                  25                  30          


Pro Pro Gly Gln Gln Thr Thr Ala His Ser Ser Val Leu Ala Gly Asn 
        35                  40                  45              


Ser Gln Glu Gln Trp His Pro Leu Arg Glu Trp Leu Gly Arg Leu Glu 
    50                  55                  60                  


Ala Ala Val Met Glu Leu Arg Glu Gln Asn Lys Asp Leu Gln Thr Arg 
65                  70                  75                  80  


Val Arg Gln Leu Glu Ser Cys Glu Cys His Pro Ala Ser Pro Gln Cys 
                85                  90                  95      


Trp Gly Leu Gly Arg Ala Trp Pro Glu Gly Ala Arg Trp Glu Pro Asp 
            100                 105                 110         


Ala Cys Thr Ala Cys Val Cys Gln Asp Gly Ala Ala His Cys Gly Pro 
        115                 120                 125             


Gln Ala His Leu Pro His Cys Arg Gly Cys Ser Gln Asn Gly Gln Thr 
    130                 135                 140                 


Tyr Gly Asn Gly Glu Thr Phe Ser Pro Asp Ala Cys Thr Thr Cys Arg 
145                 150                 155                 160 


Cys Leu Thr Gly Ala Val Gln Cys Gln Gly Pro Ser Cys Ser Glu Leu 
                165                 170                 175     


Asn Cys Leu Glu Ser Cys Thr Pro Pro Gly Glu Cys Cys Pro Ile Cys 
            180                 185                 190         


Arg Cys Thr Glu Gly Gly Ser His Trp Glu His Gly Gln Glu Trp Thr 
        195                 200                 205             


Thr Pro Gly Asp Pro Cys Arg Ile Cys Arg Cys Leu Glu Gly His Ile 
    210                 215                 220                 


Gln Cys Arg Gln Arg Glu Cys Ala Ser Leu Cys Pro Tyr Pro Ala Arg 
225                 230                 235                 240 


Pro Leu Pro Gly Thr Cys Cys Pro Val Cys Asp Gly Cys Phe Leu Asn 
                245                 250                 255     


Gly Arg Glu His Arg Ser Gly Glu Pro Val Gly Ser Gly Asp Pro Cys 
            260                 265                 270         


Ser His Cys Arg Cys Ala Asn Gly Ser Val Gln Cys Glu Pro Leu Pro 
        275                 280                 285             


Cys Pro Pro Val Pro Cys Arg His Pro Gly Lys Ile Pro Gly Gln Cys 
    290                 295                 300                 


Cys Pro Val Cys Asp Gly Cys Glu Tyr Gln Gly His Gln Tyr Gln Ser 
305                 310                 315                 320 


Gln Glu Thr Phe Arg Leu Gln Glu Arg Gly Leu Cys Val Arg Cys Ser 
                325                 330                 335     


Cys Gln Ala Gly Glu Val Ser Cys Glu Glu Gln Glu Cys Pro Val Thr 
            340                 345                 350         


Pro Cys Ala Leu Pro Ala Ser Gly Arg Gln Leu Cys Pro Ala Cys Glu 
        355                 360                 365             


Leu Asp Gly Glu Glu Phe Ala Glu Gly Val Gln Trp Glu Pro Asp Gly 
    370                 375                 380                 


Arg Pro Cys Thr Ala Cys Val Cys Gln Asp Gly Val Pro Lys Cys Gly 
385                 390                 395                 400 


Ala Val Leu Cys Pro Pro Ala Pro Cys Gln His Pro Thr Gln Pro Pro 
                405                 410                 415     


Gly Ala Cys Cys Pro Ser Cys Asp Ser Cys Thr Tyr His Ser Gln Val 
            420                 425                 430         


Tyr Ala Asn Gly Gln Asn Phe Thr Asp Ala Asp Ser Pro Cys His Ala 
        435                 440                 445             


Cys His Cys Gln Asp Gly Thr Val Thr Cys Ser Leu Val Asp Cys Pro 
    450                 455                 460                 


Pro Thr Thr Cys Ala Arg Pro Gln Ser Gly Pro Gly Gln Cys Cys Pro 
465                 470                 475                 480 


Arg Cys Pro Asp Cys Ile Leu Glu Glu Glu Val Phe Val Asp Gly Glu 
                485                 490                 495     


Ser Phe Ser His Pro Arg Asp Pro Cys Gln Glu Cys Arg Cys Gln Glu 
            500                 505                 510         


Gly His Ala His Cys Gln Pro Arg Pro Cys Pro Arg Ala Pro Cys Ala 
        515                 520                 525             


His Pro Leu Pro Gly Thr Cys Cys Pro Asn Asp Cys Ser Gly Cys Ala 
    530                 535                 540                 


Phe Gly Gly Lys Glu Tyr Pro Ser Gly Ala Asp Phe Pro His Pro Ser 
545                 550                 555                 560 


Asp Pro Cys Arg Leu Cys Arg Cys Leu Ser Gly Asn Val Gln Cys Leu 
                565                 570                 575     


Ala Arg Arg Cys Val Pro Leu Pro Cys Pro Glu Pro Val Leu Leu Pro 
            580                 585                 590         


Gly Glu Cys Cys Pro Gln Cys Pro Ala Pro Ala Gly Cys Pro Arg Pro 
        595                 600                 605             


Gly Ala Ala His Ala Arg His Gln Glu Tyr Phe Ser Pro Pro Gly Asp 
    610                 615                 620                 


Pro Cys Arg Arg Cys Leu Cys Leu Asp Gly Ser Val Ser Cys Gln Arg 
625                 630                 635                 640 


Leu Pro Cys Pro Pro Ala Pro Cys Ala His Pro Arg Gln Gly Pro Cys 
                645                 650                 655     


Cys Pro Ser Cys Asp Gly Cys Leu Tyr Gln Gly Lys Glu Phe Ala Ser 
            660                 665                 670         


Gly Glu Arg Phe Pro Ser Pro Thr Ala Ala Cys His Leu Cys Leu Cys 
        675                 680                 685             


Trp Glu Gly Ser Val Ser Cys Glu Pro Lys Ala Cys Ala Pro Ala Leu 
    690                 695                 700                 


Cys Pro Phe Pro Ala Arg Gly Asp Cys Cys Pro Asp Cys Asp Gly Cys 
705                 710                 715                 720 


Glu Tyr Leu Gly Glu Ser Tyr Leu Ser Asn Gln Glu Phe Pro Asp Pro 
                725                 730                 735     


Arg Glu Pro Cys Asn Leu Cys Thr Cys Leu Gly Gly Phe Val Thr Cys 
            740                 745                 750         


Gly Arg Arg Pro Cys Glu Pro Pro Gly Cys Ser His Pro Leu Ile Pro 
        755                 760                 765             


Ser Gly His Cys Cys Pro Thr Cys Gln Gly Cys Arg Tyr His Gly Val 
    770                 775                 780                 


Thr Thr Ala Ser Gly Glu Thr Leu Pro Asp Pro Leu Asp Pro Thr Cys 
785                 790                 795                 800 


Ser Leu Cys Thr Cys Gln Glu Gly Ser Met Arg Cys Gln Lys Lys Pro 
                805                 810                 815     


Cys Pro Pro Ala Leu Cys Pro His Pro Ser Pro Gly Pro Cys Phe Cys 
            820                 825                 830         


Pro Val Cys His Ser Cys Leu Ser Gln Gly Arg Glu His Gln Asp Gly 
        835                 840                 845             


Glu Glu Phe Glu Gly Pro Ala Gly Ser Cys Glu Trp Cys Arg Cys Gln 
    850                 855                 860                 


Ala Gly Gln Val Ser Cys Val Arg Leu Gln Cys Pro Pro Leu Pro Cys 
865                 870                 875                 880 


Lys Leu Gln Val Thr Glu Arg Gly Ser Cys Cys Pro Arg Cys Arg Gly 
                885                 890                 895     


Cys Leu Ala His Gly Glu Glu His Pro Glu Gly Ser Arg Trp Val Pro 
            900                 905                 910         


Pro Asp Ser Ala Cys Ser Ser Cys Val Cys His Glu Gly Val Val Thr 
        915                 920                 925             


Cys Ala Arg Ile Gln Cys Ile Ser Ser Cys Ala Gln Pro Arg Gln Gly 
    930                 935                 940                 


Pro His Asp Cys Cys Pro Gln Cys Ser Asp Cys Glu His Glu Gly Arg 
945                 950                 955                 960 


Lys Tyr Glu Pro Gly Glu Ser Phe Gln Pro Gly Ala Asp Pro Cys Glu 
                965                 970                 975     


Val Cys Ile Cys Glu Pro Gln Pro Glu Gly Pro Pro Ser Leu Arg Cys 
            980                 985                 990         


His Arg Arg Gln Cys Pro Ser Leu  Val Gly Cys Pro Pro  Ser Gln Leu 
        995                 1000                 1005             


Leu Pro  Pro Gly Pro Gln His  Cys Cys Pro Thr Cys  Ala Glu Ala 
    1010                 1015                 1020             


Leu Ser  Asn Cys Ser Glu Gly  Leu Leu Gly Ser Glu  Leu Ala Pro 
    1025                 1030                 1035             


Pro Asp  Pro Cys Tyr Thr Cys  Gln Cys Gln Asp Leu  Thr Trp Leu 
    1040                 1045                 1050             


Cys Ile  His Gln Ala Cys Pro  Glu Leu Ser Cys Pro  Leu Ser Glu 
    1055                 1060                 1065             


Arg His  Thr Pro Pro Gly Ser  Cys Cys Pro Val Cys  Arg Ala Pro 
    1070                 1075                 1080             


Thr Gln  Ser Cys Val His Gln  Gly Arg Glu Val Ala  Ser Gly Glu 
    1085                 1090                 1095             


Arg Trp  Thr Val Asp Thr Cys  Thr Ser Cys Ser Cys  Met Ala Gly 
    1100                 1105                 1110             


Thr Val  Arg Cys Gln Ser Gln  Arg Cys Ser Pro Leu  Ser Cys Gly 
    1115                 1120                 1125             


Pro Asp  Lys Ala Pro Ala Leu  Ser Pro Gly Ser Cys  Cys Pro Arg 
    1130                 1135                 1140             


Cys Leu  Pro Arg Pro Ala Ser  Cys Met Ala Phe Gly  Asp Pro His 
    1145                 1150                 1155             


Tyr Arg  Thr Phe Asp Gly Arg  Leu Leu His Phe Gln  Gly Ser Cys 
    1160                 1165                 1170             


Ser Tyr  Val Leu Ala Lys Asp  Cys His Ser Gly Asp  Phe Ser Val 
    1175                 1180                 1185             


His Val  Thr Asn Asp Asp Arg  Gly Arg Ser Gly Val  Ala Trp Thr 
    1190                 1195                 1200             


Gln Glu  Val Ala Val Leu Leu  Gly Asp Met Ala Val  Arg Leu Leu 
    1205                 1210                 1215             


Gln Asp  Gly Ala Val Thr Val  Asp Gly His Pro Val  Ala Leu Pro 
    1220                 1225                 1230             


Phe Leu  Gln Glu Pro Leu Leu  Tyr Val Glu Leu Arg  Gly His Thr 
    1235                 1240                 1245             


Val Ile  Leu His Ala Gln Pro  Gly Leu Gln Val Leu  Trp Asp Gly 
    1250                 1255                 1260             


Gln Ser  Gln Val Glu Val Ser  Val Pro Gly Ser Tyr  Gln Gly Arg 
    1265                 1270                 1275             


Thr Cys  Gly Leu Cys Gly Asn  Phe Asn Gly Phe Ala  Gln Asp Asp 
    1280                 1285                 1290             


Leu Gln  Gly Pro Glu Gly Leu  Leu Leu Pro Ser Glu  Ala Ala Phe 
    1295                 1300                 1305             


Gly Asn  Ser Trp Gln Val Ser  Glu Gly Leu Trp Pro  Gly Arg Pro 
    1310                 1315                 1320             


Cys Ser  Ala Gly Arg Glu Val  Asp Pro Cys Arg Ala  Ala Gly Tyr 
    1325                 1330                 1335             


Arg Ala  Arg Arg Glu Ala Asn  Ala Arg Cys Gly Val  Leu Lys Ser 
    1340                 1345                 1350             


Ser Pro  Phe Ser Arg Cys His  Ala Val Val Pro Pro  Glu Pro Phe 
    1355                 1360                 1365             


Phe Ala  Ala Cys Val Tyr Asp  Leu Cys Ala Cys Gly  Pro Gly Ser 
    1370                 1375                 1380             


Ser Ala  Asp Ala Cys Leu Cys  Asp Ala Leu Glu Ala  Tyr Ala Ser 
    1385                 1390                 1395             


His Cys  Arg Gln Ala Gly Val  Thr Pro Thr Trp Arg  Gly Pro Thr 
    1400                 1405                 1410             


Leu Cys  Val Val Gly Cys Pro  Leu Glu Arg Gly Phe  Val Phe Asp 
    1415                 1420                 1425             


Glu Cys  Gly Pro Pro Cys Pro  Arg Thr Cys Phe Asn  Gln His Ile 
    1430                 1435                 1440             


Pro Leu  Gly Glu Leu Ala Ala  His Cys Val Arg Pro  Cys Val Pro 
    1445                 1450                 1455             


Gly Cys  Gln Cys Pro Ala Gly  Leu Val Glu His Glu  Ala His Cys 
    1460                 1465                 1470             


Ile Pro  Pro Glu Ala Cys Pro  Gln Val Leu Leu Thr  Gly Asp Gln 
    1475                 1480                 1485             


Pro Leu  Gly Ala Arg Pro Ser  Pro Ser Arg Glu Pro  Gln Glu Thr 
    1490                 1495                 1500             


Pro 
    


<210>  7403
<211>  1568
<212>  PRT
<213>  Homo Sapiens

<400>  7403

Met Ala Gly Val Gly Ala Ala Ala Leu Ser Leu Leu Leu His Leu Gly 
1               5                   10                  15      


Ala Leu Ala Leu Ala Ala Gly Ala Glu Gly Gly Ala Val Pro Arg Glu 
            20                  25                  30          


Pro Pro Gly Gln Gln Thr Thr Ala His Ser Ser Val Leu Ala Gly Asn 
        35                  40                  45              


Ser Gln Glu Gln Trp His Pro Leu Arg Glu Trp Leu Gly Arg Leu Glu 
    50                  55                  60                  


Ala Ala Val Met Glu Leu Arg Glu Gln Asn Lys Asp Leu Gln Thr Arg 
65                  70                  75                  80  


Val Arg Gln Leu Glu Ser Cys Glu Cys His Pro Ala Ser Pro Gln Cys 
                85                  90                  95      


Trp Gly Leu Gly Arg Ala Trp Pro Glu Gly Ala Arg Trp Glu Pro Asp 
            100                 105                 110         


Ala Cys Thr Ala Cys Val Cys Gln Asp Gly Ala Ala His Cys Gly Pro 
        115                 120                 125             


Gln Ala His Leu Pro His Cys Arg Gly Cys Ser Gln Asn Gly Gln Thr 
    130                 135                 140                 


Tyr Gly Asn Gly Glu Thr Phe Ser Pro Asp Ala Cys Thr Thr Cys Arg 
145                 150                 155                 160 


Cys Leu Thr Gly Ala Val Gln Cys Gln Gly Pro Ser Cys Ser Glu Leu 
                165                 170                 175     


Asn Cys Leu Glu Ser Cys Thr Pro Pro Gly Glu Cys Cys Pro Ile Cys 
            180                 185                 190         


Arg Pro Gly Cys Asp Tyr Glu Gly Gln Leu Tyr Glu Glu Gly Val Thr 
        195                 200                 205             


Phe Leu Ser Ser Ser Asn Pro Cys Leu Gln Cys Thr Cys Leu Arg Ser 
    210                 215                 220                 


Arg Val Arg Cys Met Ala Leu Lys Cys Pro Pro Ser Pro Cys Pro Glu 
225                 230                 235                 240 


Pro Val Leu Arg Pro Gly His Cys Cys Pro Thr Cys Gln Gly Cys Thr 
                245                 250                 255     


Glu Gly Gly Ser His Trp Glu His Gly Gln Glu Trp Thr Thr Pro Gly 
            260                 265                 270         


Asp Pro Cys Arg Ile Cys Arg Cys Leu Glu Gly His Ile Gln Cys Arg 
        275                 280                 285             


Gln Arg Glu Cys Ala Ser Leu Cys Pro Tyr Pro Ala Arg Pro Leu Pro 
    290                 295                 300                 


Gly Thr Cys Cys Pro Val Cys Asp Gly Cys Phe Leu Asn Gly Arg Glu 
305                 310                 315                 320 


His Arg Ser Gly Glu Pro Val Gly Ser Gly Asp Pro Cys Ser His Cys 
                325                 330                 335     


Arg Cys Ala Asn Gly Ser Val Gln Cys Glu Pro Leu Pro Cys Pro Pro 
            340                 345                 350         


Val Pro Cys Arg His Pro Gly Lys Ile Pro Gly Gln Cys Cys Pro Val 
        355                 360                 365             


Cys Asp Gly Cys Glu Tyr Gln Gly His Gln Tyr Gln Ser Gln Glu Thr 
    370                 375                 380                 


Phe Arg Leu Gln Glu Arg Gly Leu Cys Val Arg Cys Ser Cys Gln Ala 
385                 390                 395                 400 


Gly Glu Val Ser Cys Glu Glu Gln Glu Cys Pro Val Thr Pro Cys Ala 
                405                 410                 415     


Leu Pro Ala Ser Gly Arg Gln Leu Cys Pro Ala Cys Glu Leu Asp Gly 
            420                 425                 430         


Glu Glu Phe Ala Glu Gly Val Gln Trp Glu Pro Asp Gly Arg Pro Cys 
        435                 440                 445             


Thr Ala Cys Val Cys Gln Asp Gly Val Pro Lys Cys Gly Ala Val Leu 
    450                 455                 460                 


Cys Pro Pro Ala Pro Cys Gln His Pro Thr Gln Pro Pro Gly Ala Cys 
465                 470                 475                 480 


Cys Pro Ser Cys Asp Ser Cys Thr Tyr His Ser Gln Val Tyr Ala Asn 
                485                 490                 495     


Gly Gln Asn Phe Thr Asp Ala Asp Ser Pro Cys His Ala Cys His Cys 
            500                 505                 510         


Gln Asp Gly Thr Val Thr Cys Ser Leu Val Asp Cys Pro Pro Thr Thr 
        515                 520                 525             


Cys Ala Arg Pro Gln Ser Gly Pro Gly Gln Cys Cys Pro Arg Cys Pro 
    530                 535                 540                 


Asp Cys Ile Leu Glu Glu Glu Val Phe Val Asp Gly Glu Ser Phe Ser 
545                 550                 555                 560 


His Pro Arg Asp Pro Cys Gln Glu Cys Arg Cys Gln Glu Gly His Ala 
                565                 570                 575     


His Cys Gln Pro Arg Pro Cys Pro Arg Ala Pro Cys Ala His Pro Leu 
            580                 585                 590         


Pro Gly Thr Cys Cys Pro Asn Asp Cys Ser Gly Cys Ala Phe Gly Gly 
        595                 600                 605             


Lys Glu Tyr Pro Ser Gly Ala Asp Phe Pro His Pro Ser Asp Pro Cys 
    610                 615                 620                 


Arg Leu Cys Arg Cys Leu Ser Gly Asn Val Gln Cys Leu Ala Arg Arg 
625                 630                 635                 640 


Cys Val Pro Leu Pro Cys Pro Glu Pro Val Leu Leu Pro Gly Glu Cys 
                645                 650                 655     


Cys Pro Gln Cys Pro Ala Ala Pro Ala Pro Ala Gly Cys Pro Arg Pro 
            660                 665                 670         


Gly Ala Ala His Ala Arg His Gln Glu Tyr Phe Ser Pro Pro Gly Asp 
        675                 680                 685             


Pro Cys Arg Arg Cys Leu Cys Leu Asp Gly Ser Val Ser Cys Gln Arg 
    690                 695                 700                 


Leu Pro Cys Pro Pro Ala Pro Cys Ala His Pro Arg Gln Gly Pro Cys 
705                 710                 715                 720 


Cys Pro Ser Cys Asp Gly Cys Leu Tyr Gln Gly Lys Glu Phe Ala Ser 
                725                 730                 735     


Gly Glu Arg Phe Pro Ser Pro Thr Ala Ala Cys His Leu Cys Leu Cys 
            740                 745                 750         


Trp Glu Gly Ser Val Ser Cys Glu Pro Lys Ala Cys Ala Pro Ala Leu 
        755                 760                 765             


Cys Pro Phe Pro Ala Arg Gly Asp Cys Cys Pro Asp Cys Asp Gly Cys 
    770                 775                 780                 


Glu Tyr Leu Gly Glu Ser Tyr Leu Ser Asn Gln Glu Phe Pro Asp Pro 
785                 790                 795                 800 


Arg Glu Pro Cys Asn Leu Cys Thr Cys Leu Gly Gly Phe Val Thr Cys 
                805                 810                 815     


Gly Arg Arg Pro Cys Glu Pro Pro Gly Cys Ser His Pro Leu Ile Pro 
            820                 825                 830         


Ser Gly His Cys Cys Pro Thr Cys Gln Gly Cys Arg Tyr His Gly Val 
        835                 840                 845             


Thr Thr Ala Ser Gly Glu Thr Leu Pro Asp Pro Leu Asp Pro Thr Cys 
    850                 855                 860                 


Ser Leu Cys Thr Cys Gln Glu Gly Ser Met Arg Cys Gln Lys Lys Pro 
865                 870                 875                 880 


Cys Pro Pro Ala Leu Cys Pro His Pro Ser Pro Gly Pro Cys Phe Cys 
                885                 890                 895     


Pro Val Cys His Ser Cys Leu Ser Gln Gly Arg Glu His Gln Asp Gly 
            900                 905                 910         


Glu Glu Phe Glu Gly Pro Ala Gly Ser Cys Glu Trp Cys Arg Cys Gln 
        915                 920                 925             


Ala Gly Gln Val Ser Cys Val Arg Leu Gln Cys Pro Pro Leu Pro Cys 
    930                 935                 940                 


Lys Leu Gln Val Thr Glu Arg Gly Ser Cys Cys Pro Arg Cys Arg Gly 
945                 950                 955                 960 


Cys Leu Ala His Gly Glu Glu His Pro Glu Gly Ser Arg Trp Val Pro 
                965                 970                 975     


Pro Asp Ser Ala Cys Ser Ser Cys Val Cys His Glu Gly Val Val Thr 
            980                 985                 990         


Cys Ala Arg Ile Gln Cys Ile Ser  Ser Cys Ala Gln Pro  Arg Gln Gly 
        995                 1000                 1005             


Pro His  Asp Cys Cys Pro Gln  Cys Ser Asp Cys Glu  His Glu Gly 
    1010                 1015                 1020             


Arg Lys  Tyr Glu Pro Gly Glu  Ser Phe Gln Pro Gly  Ala Asp Pro 
    1025                 1030                 1035             


Cys Glu  Val Cys Ile Cys Glu  Pro Gln Pro Glu Gly  Pro Pro Ser 
    1040                 1045                 1050             


Leu Arg  Cys His Arg Arg Gln  Cys Pro Ser Leu Val  Gly Cys Pro 
    1055                 1060                 1065             


Pro Ser  Gln Leu Leu Pro Pro  Gly Pro Gln His Cys  Cys Pro Thr 
    1070                 1075                 1080             


Cys Ala  Glu Ala Leu Ser Asn  Cys Ser Glu Gly Leu  Leu Gly Ser 
    1085                 1090                 1095             


Glu Leu  Ala Pro Pro Asp Pro  Cys Tyr Thr Cys Gln  Cys Gln Asp 
    1100                 1105                 1110             


Leu Thr  Trp Leu Cys Ile His  Gln Ala Cys Pro Glu  Leu Ser Cys 
    1115                 1120                 1125             


Pro Leu  Ser Glu Arg His Thr  Pro Pro Gly Ser Cys  Cys Pro Val 
    1130                 1135                 1140             


Cys Arg  Ala Pro Thr Gln Ser  Cys Val His Gln Gly  Arg Glu Val 
    1145                 1150                 1155             


Ala Ser  Gly Glu Arg Trp Thr  Val Asp Thr Cys Thr  Ser Cys Ser 
    1160                 1165                 1170             


Cys Met  Ala Gly Thr Val Arg  Cys Gln Ser Gln Arg  Cys Ser Pro 
    1175                 1180                 1185             


Leu Ser  Cys Gly Pro Asp Lys  Ala Pro Ala Leu Ser  Pro Gly Ser 
    1190                 1195                 1200             


Cys Cys  Pro Arg Cys Leu Pro  Arg Pro Ala Ser Cys  Met Ala Phe 
    1205                 1210                 1215             


Gly Asp  Pro His Tyr Arg Thr  Phe Asp Gly Arg Leu  Leu His Phe 
    1220                 1225                 1230             


Gln Gly  Ser Cys Ser Tyr Val  Leu Ala Lys Asp Cys  His Ser Gly 
    1235                 1240                 1245             


Asp Phe  Ser Val His Val Thr  Asn Asp Asp Arg Gly  Arg Ser Gly 
    1250                 1255                 1260             


Val Ala  Trp Thr Gln Glu Val  Ala Val Leu Leu Gly  Asp Met Ala 
    1265                 1270                 1275             


Val Arg  Leu Leu Gln Asp Gly  Ala Val Thr Val Asp  Gly His Pro 
    1280                 1285                 1290             


Val Ala  Leu Pro Phe Leu Gln  Glu Pro Leu Leu Tyr  Val Glu Leu 
    1295                 1300                 1305             


Arg Gly  His Thr Val Ile Leu  His Ala Gln Pro Gly  Leu Gln Val 
    1310                 1315                 1320             


Leu Trp  Asp Gly Gln Ser Gln  Val Glu Val Ser Val  Pro Gly Ser 
    1325                 1330                 1335             


Tyr Gln  Gly Arg Thr Cys Gly  Leu Cys Gly Asn Phe  Asn Gly Phe 
    1340                 1345                 1350             


Ala Gln  Asp Asp Leu Gln Gly  Pro Glu Gly Leu Leu  Leu Pro Ser 
    1355                 1360                 1365             


Glu Ala  Ala Phe Gly Asn Ser  Trp Gln Val Ser Glu  Gly Leu Trp 
    1370                 1375                 1380             


Pro Gly  Arg Pro Cys Ser Ala  Gly Arg Glu Val Asp  Pro Cys Arg 
    1385                 1390                 1395             


Ala Ala  Gly Tyr Arg Ala Arg  Arg Glu Ala Asn Ala  Arg Cys Gly 
    1400                 1405                 1410             


Val Leu  Lys Ser Ser Pro Phe  Ser Arg Cys His Ala  Val Val Pro 
    1415                 1420                 1425             


Pro Glu  Pro Phe Phe Ala Ala  Cys Val Tyr Asp Leu  Cys Ala Cys 
    1430                 1435                 1440             


Gly Pro  Gly Ser Ser Ala Asp  Ala Cys Leu Cys Asp  Ala Leu Glu 
    1445                 1450                 1455             


Ala Tyr  Ala Ser His Cys Arg  Gln Ala Gly Val Thr  Pro Thr Trp 
    1460                 1465                 1470             


Arg Gly  Pro Thr Leu Cys Val  Val Gly Cys Pro Leu  Glu Arg Gly 
    1475                 1480                 1485             


Phe Val  Phe Asp Glu Cys Gly  Pro Pro Cys Pro Arg  Thr Cys Phe 
    1490                 1495                 1500             


Asn Gln  His Ile Pro Leu Gly  Glu Leu Ala Ala His  Cys Val Arg 
    1505                 1510                 1515             


Pro Cys  Val Pro Gly Cys Gln  Cys Pro Ala Gly Leu  Val Glu His 
    1520                 1525                 1530             


Glu Ala  His Cys Ile Pro Pro  Glu Ala Cys Pro Gln  Val Leu Leu 
    1535                 1540                 1545             


Thr Gly  Asp Gln Pro Leu Gly  Ala Arg Pro Ser Pro  Ser Arg Glu 
    1550                 1555                 1560             


Pro Gln  Glu Thr Pro 
    1565             


<210>  7404
<211>  1275
<212>  PRT
<213>  Homo Sapiens

<400>  7404

Met Ala Gly Val Gly Ala Ala Ala Leu Ser Leu Leu Leu His Leu Gly 
1               5                   10                  15      


Ala Leu Ala Leu Ala Ala Gly Ala Glu Gly Gly Ala Val Pro Arg Glu 
            20                  25                  30          


Pro Pro Gly Gln Gln Thr Thr Ala His Ser Ser Val Leu Ala Gly Asn 
        35                  40                  45              


Ser Gln Glu Gln Trp His Pro Leu Arg Glu Trp Leu Gly Arg Leu Glu 
    50                  55                  60                  


Ala Ala Val Met Glu Leu Arg Glu Gln Asn Lys Asp Leu Gln Thr Arg 
65                  70                  75                  80  


Val Arg Gln Leu Glu Ser Cys Glu Cys His Pro Ala Ser Pro Gln Cys 
                85                  90                  95      


Trp Gly Leu Gly Arg Ala Trp Pro Glu Gly Ala Arg Trp Glu Pro Asp 
            100                 105                 110         


Ala Cys Thr Ala Cys Val Cys Gln Asp Gly Ala Ala His Cys Gly Pro 
        115                 120                 125             


Gln Ala His Leu Pro His Cys Arg Gly Cys Ser Gln Asn Gly Gln Thr 
    130                 135                 140                 


Tyr Gly Asn Gly Glu Thr Phe Ser Pro Asp Ala Cys Thr Thr Cys Arg 
145                 150                 155                 160 


Cys Leu Thr Gly Ala Val Gln Cys Gln Gly Pro Ser Cys Ser Glu Leu 
                165                 170                 175     


Asn Cys Leu Glu Ser Cys Thr Pro Pro Gly Glu Cys Cys Pro Ile Cys 
            180                 185                 190         


Arg Pro Gly Cys Asp Tyr Glu Gly Gln Leu Tyr Glu Glu Gly Val Thr 
        195                 200                 205             


Phe Leu Ser Ser Ser Asn Pro Cys Leu Gln Cys Thr Cys Leu Arg Ser 
    210                 215                 220                 


Arg Val Arg Cys Met Ala Leu Lys Cys Pro Pro Ser Pro Cys Pro Glu 
225                 230                 235                 240 


Pro Val Leu Arg Pro Gly His Cys Cys Pro Thr Cys Gln Gly Cys Thr 
                245                 250                 255     


Glu Gly Gly Ser His Trp Glu His Gly Gln Glu Trp Thr Thr Pro Gly 
            260                 265                 270         


Asp Pro Cys Arg Ile Cys Arg Cys Leu Glu Gly His Ile Gln Cys Arg 
        275                 280                 285             


Gln Arg Glu Cys Ala Ser Leu Cys Pro Tyr Pro Ala Arg Pro Leu Pro 
    290                 295                 300                 


Gly Thr Cys Cys Pro Val Cys Asp Gly Cys Phe Leu Asn Gly Arg Glu 
305                 310                 315                 320 


His Arg Ser Gly Glu Pro Val Gly Ser Gly Asp Pro Cys Ser His Cys 
                325                 330                 335     


Arg Cys Ala Asn Gly Ser Val Gln Cys Glu Pro Leu Pro Cys Pro Pro 
            340                 345                 350         


Val Pro Cys Arg His Pro Gly Lys Ile Pro Gly Gln Cys Cys Pro Val 
        355                 360                 365             


Cys Asp Gly Cys Glu Tyr Gln Gly His Gln Tyr Gln Ser Gln Glu Thr 
    370                 375                 380                 


Phe Arg Leu Gln Glu Arg Gly Leu Cys Val Arg Cys Ser Cys Gln Ala 
385                 390                 395                 400 


Gly Glu Val Ser Cys Glu Glu Gln Glu Cys Pro Val Thr Pro Cys Ala 
                405                 410                 415     


Leu Pro Ala Ser Gly Arg Gln Leu Cys Pro Ala Cys Glu Leu Asp Gly 
            420                 425                 430         


Glu Glu Phe Ala Glu Gly Val Gln Trp Glu Pro Asp Gly Arg Pro Cys 
        435                 440                 445             


Thr Ala Cys Val Cys Gln Asp Gly Val Pro Lys Cys Gly Ala Val Leu 
    450                 455                 460                 


Cys Pro Pro Ala Pro Cys Gln His Pro Thr Gln Pro Pro Gly Ala Cys 
465                 470                 475                 480 


Cys Pro Ser Cys Asp Ser Cys Thr Tyr His Ser Gln Val Tyr Ala Asn 
                485                 490                 495     


Gly Gln Asn Phe Thr Asp Ala Asp Ser Pro Cys His Ala Cys His Cys 
            500                 505                 510         


Gln Asp Gly Thr Val Thr Cys Ser Leu Val Asp Cys Pro Pro Thr Thr 
        515                 520                 525             


Cys Ala Arg Pro Gln Ser Gly Pro Gly Gln Cys Cys Pro Arg Cys Pro 
    530                 535                 540                 


Asp Cys Ile Leu Glu Glu Glu Val Phe Val Asp Gly Glu Ser Phe Ser 
545                 550                 555                 560 


His Pro Arg Asp Pro Cys Gln Glu Cys Arg Cys Gln Glu Gly His Ala 
                565                 570                 575     


His Cys Gln Pro Arg Pro Cys Pro Arg Ala Pro Cys Ala His Pro Leu 
            580                 585                 590         


Pro Gly Thr Cys Cys Pro Asn Asp Cys Ser Gly Cys Ala Phe Gly Gly 
        595                 600                 605             


Lys Glu Tyr Pro Ser Gly Ala Asp Phe Pro His Pro Ser Asp Pro Cys 
    610                 615                 620                 


Arg Leu Cys Arg Cys Leu Ser Gly Asn Val Gln Cys Leu Ala Arg Arg 
625                 630                 635                 640 


Cys Val Pro Leu Pro Cys Pro Glu Pro Val Leu Leu Pro Gly Glu Cys 
                645                 650                 655     


Cys Pro Gln Cys Pro Ala Ala Pro Ala Pro Ala Gly Cys Pro Arg Pro 
            660                 665                 670         


Gly Ala Ala His Ala Arg His Gln Glu Tyr Phe Ser Pro Pro Gly Asp 
        675                 680                 685             


Pro Cys Arg Arg Cys Leu Cys Leu Asp Gly Ser Val Ser Cys Gln Arg 
    690                 695                 700                 


Leu Pro Cys Pro Pro Ala Pro Cys Ala His Pro Arg Gln Gly Pro Cys 
705                 710                 715                 720 


Cys Pro Ser Cys Asp Gly Cys Leu Tyr Gln Gly Lys Glu Phe Ala Ser 
                725                 730                 735     


Gly Glu Arg Phe Pro Ser Pro Thr Ala Ala Cys His Leu Cys Leu Cys 
            740                 745                 750         


Trp Glu Gly Ser Val Ser Cys Glu Pro Lys Ala Cys Ala Pro Ala Leu 
        755                 760                 765             


Cys Pro Phe Pro Ala Arg Gly Asp Cys Cys Pro Asp Cys Asp Gly Cys 
    770                 775                 780                 


Glu Tyr Leu Gly Glu Ser Tyr Leu Ser Asn Gln Glu Phe Pro Asp Pro 
785                 790                 795                 800 


Arg Glu Pro Cys Asn Leu Cys Thr Cys Leu Gly Gly Phe Val Thr Cys 
                805                 810                 815     


Gly Arg Arg Pro Cys Glu Pro Pro Gly Cys Ser His Pro Leu Ile Pro 
            820                 825                 830         


Ser Gly His Cys Cys Pro Thr Cys Gln Gly Cys Arg Tyr His Gly Val 
        835                 840                 845             


Thr Thr Ala Ser Gly Glu Thr Leu Pro Asp Pro Leu Asp Pro Thr Cys 
    850                 855                 860                 


Ser Leu Cys Thr Cys Gln Glu Gly Ser Met Arg Cys Gln Lys Lys Pro 
865                 870                 875                 880 


Cys Pro Pro Ala Leu Cys Pro His Pro Ser Pro Gly Pro Cys Phe Cys 
                885                 890                 895     


Pro Val Cys His Ser Cys Leu Ser Gln Gly Arg Glu His Gln Asp Gly 
            900                 905                 910         


Glu Glu Phe Glu Gly Pro Ala Gly Ser Cys Glu Trp Cys Arg Cys Gln 
        915                 920                 925             


Ala Gly Gln Val Ser Cys Val Arg Leu Gln Cys Pro Pro Leu Pro Cys 
    930                 935                 940                 


Lys Leu Gln Val Thr Glu Arg Gly Ser Cys Cys Pro Arg Cys Arg Gly 
945                 950                 955                 960 


Cys Leu Ala His Gly Glu Glu His Pro Glu Gly Ser Arg Trp Val Pro 
                965                 970                 975     


Pro Asp Ser Ala Cys Ser Ser Cys Val Cys His Glu Gly Val Val Thr 
            980                 985                 990         


Cys Ala Arg Ile Gln Cys Ile Ser  Ser Cys Ala Gln Pro  Arg Gln Gly 
        995                 1000                 1005             


Pro His  Asp Cys Cys Pro Gln  Cys Ser Asp Cys Glu  His Glu Gly 
    1010                 1015                 1020             


Arg Lys  Tyr Glu Pro Gly Glu  Ser Phe Gln Pro Gly  Ala Asp Pro 
    1025                 1030                 1035             


Cys Glu  Val Cys Ile Cys Glu  Pro Gln Pro Glu Gly  Pro Pro Ser 
    1040                 1045                 1050             


Leu Arg  Cys His Arg Arg Gln  Cys Pro Ser Leu Val  Gly Cys Pro 
    1055                 1060                 1065             


Pro Ser  Gln Leu Leu Pro Pro  Gly Pro Gln His Cys  Cys Pro Thr 
    1070                 1075                 1080             


Cys Ala  Glu Ala Leu Ser Asn  Cys Ser Glu Gly Leu  Leu Gly Ser 
    1085                 1090                 1095             


Glu Leu  Ala Pro Pro Asp Pro  Cys Tyr Thr Cys Gln  Cys Gln Asp 
    1100                 1105                 1110             


Leu Thr  Trp Leu Cys Ile His  Gln Ala Cys Pro Glu  Leu Ser Cys 
    1115                 1120                 1125             


Pro Leu  Ser Glu Arg His Thr  Pro Pro Gly Ser Cys  Cys Pro Val 
    1130                 1135                 1140             


Cys Arg  Ala Pro Thr Gln Ser  Cys Val His Gln Gly  Arg Glu Val 
    1145                 1150                 1155             


Ala Ser  Gly Glu Arg Trp Thr  Val Asp Thr Cys Thr  Ser Cys Ser 
    1160                 1165                 1170             


Cys Met  Ala Gly Thr Val Arg  Cys Gln Ser Gln Arg  Cys Ser Pro 
    1175                 1180                 1185             


Leu Ser  Cys Gly Pro Asp Lys  Ala Pro Ala Leu Ser  Pro Gly Ser 
    1190                 1195                 1200             


Cys Cys  Pro Arg Cys Leu Pro  Arg Pro Ala Ser Cys  Met Ala Phe 
    1205                 1210                 1215             


Gly Asp  Pro His Tyr Arg Thr  Phe Asp Gly Arg Leu  Leu His Phe 
    1220                 1225                 1230             


Gln Gly  Ser Cys Ser Tyr Val  Leu Ala Lys Asp Cys  His Ser Gly 
    1235                 1240                 1245             


Asp Phe  Arg Trp Met Gly Thr  Arg Trp Pro Cys Pro  Ser Cys Arg 
    1250                 1255                 1260             


Ser Arg  Cys Cys Met Trp Ser  Cys Glu Asp Thr Leu  
    1265                 1270                 1275 


<210>  7405
<211>  502
<212>  PRT
<213>  Homo Sapiens

<400>  7405

Met Phe Gly Thr Leu Leu Leu Tyr Cys Phe Phe Leu Ala Thr Val Pro 
1               5                   10                  15      


Ala Leu Ala Glu Thr Gly Gly Glu Arg Gln Leu Ser Pro Glu Lys Ser 
            20                  25                  30          


Glu Ile Trp Gly Pro Gly Leu Lys Ala Asp Val Val Leu Pro Ala Arg 
        35                  40                  45              


Tyr Phe Tyr Ile Gln Ala Val Asp Thr Ser Gly Asn Lys Phe Thr Ser 
    50                  55                  60                  


Ser Pro Gly Glu Lys Val Phe Gln Val Lys Val Ser Ala Pro Glu Glu 
65                  70                  75                  80  


Gln Phe Thr Arg Val Gly Val Gln Val Leu Asp Arg Lys Asp Gly Ser 
                85                  90                  95      


Phe Ile Val Arg Tyr Arg Met Tyr Ala Ser Tyr Lys Asn Leu Lys Val 
            100                 105                 110         


Glu Ile Lys Phe Gln Gly Gln His Val Ala Lys Ser Pro Tyr Ile Leu 
        115                 120                 125             


Lys Gly Pro Val Tyr His Glu Asn Cys Asp Cys Pro Leu Gln Asp Ser 
    130                 135                 140                 


Ala Ala Trp Leu Arg Glu Met Asn Cys Pro Glu Thr Ile Ala Gln Ile 
145                 150                 155                 160 


Gln Arg Asp Leu Ala His Phe Pro Ala Val Asp Pro Glu Lys Ile Ala 
                165                 170                 175     


Val Glu Ile Pro Lys Arg Phe Gly Gln Arg Gln Ser Leu Cys His Tyr 
            180                 185                 190         


Thr Leu Lys Asp Asn Lys Val Tyr Ile Lys Thr His Gly Glu His Val 
        195                 200                 205             


Gly Phe Arg Ile Phe Met Asp Ala Ile Leu Leu Ser Leu Thr Arg Lys 
    210                 215                 220                 


Val Lys Met Pro Asp Val Glu Leu Phe Val Asn Leu Gly Asp Trp Pro 
225                 230                 235                 240 


Leu Glu Lys Lys Lys Ser Asn Ser Asn Ile His Pro Ile Phe Ser Trp 
                245                 250                 255     


Cys Gly Ser Thr Asp Ser Lys Asp Ile Val Met Pro Thr Tyr Asp Leu 
            260                 265                 270         


Thr Asp Ser Val Leu Glu Thr Met Gly Arg Val Ser Leu Asp Met Met 
        275                 280                 285             


Ser Val Gln Ala Asn Thr Gly Pro Pro Trp Glu Ser Lys Asn Ser Thr 
    290                 295                 300                 


Ala Val Trp Arg Gly Arg Asp Ser Arg Lys Glu Arg Leu Glu Leu Val 
305                 310                 315                 320 


Lys Leu Ser Arg Lys His Pro Glu Leu Ile Asp Ala Ala Phe Thr Asn 
                325                 330                 335     


Phe Phe Phe Phe Lys His Asp Glu Asn Leu Tyr Gly Pro Ile Val Lys 
            340                 345                 350         


His Ile Ser Phe Phe Asp Phe Phe Lys His Lys Tyr Gln Ile Asn Ile 
        355                 360                 365             


Asp Gly Thr Val Ala Ala Tyr Arg Leu Pro Tyr Leu Leu Val Gly Asp 
    370                 375                 380                 


Ser Val Val Leu Lys Gln Asp Ser Ile Tyr Tyr Glu His Phe Tyr Asn 
385                 390                 395                 400 


Glu Leu Gln Pro Trp Lys His Tyr Ile Pro Val Lys Ser Asn Leu Ser 
                405                 410                 415     


Asp Leu Leu Glu Lys Leu Lys Trp Ala Lys Asp His Asp Glu Glu Ala 
            420                 425                 430         


Lys Lys Ile Ala Lys Ala Gly Gln Glu Phe Ala Arg Asn Asn Leu Met 
        435                 440                 445             


Gly Asp Asp Ile Phe Cys Tyr Tyr Phe Lys Leu Phe Gln Glu Tyr Ala 
    450                 455                 460                 


Asn Leu Gln Val Ser Glu Pro Gln Ile Arg Glu Gly Met Lys Arg Val 
465                 470                 475                 480 


Glu Pro Gln Thr Glu Asp Asp Leu Phe Pro Cys Thr Cys His Arg Lys 
                485                 490                 495     


Lys Thr Lys Asp Glu Leu 
            500         


<210>  7406
<211>  507
<212>  PRT
<213>  Homo Sapiens

<400>  7406

Met Arg Arg Leu Pro Arg Ala Leu Leu Leu Gln Leu Arg Leu Ala Leu 
1               5                   10                  15      


Leu Val Ala Ala Gly Ala Pro Glu Val Leu Val Ser Ala Pro Arg Ser 
            20                  25                  30          


Leu Val Trp Gly Pro Gly Leu Gln Ala Ala Val Val Leu Pro Val Arg 
        35                  40                  45              


Tyr Phe Tyr Leu Gln Ala Val Asn Ser Glu Gly Gln Asn Leu Thr Arg 
    50                  55                  60                  


Ser Pro Ala Gly Glu Thr Pro Phe Lys Val Val Val Lys Ser Leu Ser 
65                  70                  75                  80  


Pro Lys Glu Leu Val Arg Ile His Val Pro Lys Pro Leu Asp Arg Asn 
                85                  90                  95      


Asp Gly Thr Phe Leu Met Arg Tyr Arg Met Tyr Glu Thr Val Asp Glu 
            100                 105                 110         


Gly Leu Lys Ile Glu Val Leu Tyr Gly Asp Glu His Val Ala Gln Ser 
        115                 120                 125             


Pro Tyr Ile Leu Lys Gly Pro Val Tyr His Glu Tyr Cys Glu Cys Pro 
    130                 135                 140                 


Glu Asp Pro Gln Ala Trp Gln Lys Thr Leu Ser Cys Pro Thr Lys Glu 
145                 150                 155                 160 


Pro Gln Ile Ala Lys Asp Phe Ala Ser Phe Pro Ser Ile Asn Leu Gln 
                165                 170                 175     


Gln Met Leu Lys Glu Val Pro Lys Arg Phe Gly Asp Glu Arg Gly Ala 
            180                 185                 190         


Ile Val His Tyr Thr Ile Leu Asn Asn His Val Tyr Arg Arg Ser Leu 
        195                 200                 205             


Gly Lys Tyr Thr Asp Phe Lys Met Phe Ser Asp Glu Ile Leu Leu Ser 
    210                 215                 220                 


Leu Thr Arg Lys Val Leu Leu Pro Asp Leu Glu Phe Tyr Val Asn Leu 
225                 230                 235                 240 


Gly Asp Trp Pro Leu Glu His Arg Lys Val Asn Gly Thr Pro Ser Pro 
                245                 250                 255     


Ile Pro Ile Ile Ser Trp Cys Gly Ser Leu Asp Ser Arg Asp Val Val 
            260                 265                 270         


Leu Pro Thr Tyr Asp Ile Thr His Ser Met Leu Glu Ala Met Arg Gly 
        275                 280                 285             


Val Thr Asn Asp Leu Leu Ser Ile Gln Gly Asn Thr Gly Pro Ser Trp 
    290                 295                 300                 


Ile Asn Lys Thr Glu Arg Ala Phe Phe Arg Gly Arg Asp Ser Arg Glu 
305                 310                 315                 320 


Glu Arg Leu Gln Leu Val Gln Leu Ser Lys Glu Asn Pro Gln Leu Leu 
                325                 330                 335     


Asp Ala Gly Ile Thr Gly Tyr Phe Phe Phe Gln Glu Lys Glu Lys Glu 
            340                 345                 350         


Leu Gly Lys Ala Lys Leu Met Gly Phe Phe Asp Phe Phe Lys Tyr Lys 
        355                 360                 365             


Tyr Gln Val Asn Val Asp Gly Thr Val Ala Ala Tyr Arg Tyr Pro Tyr 
    370                 375                 380                 


Leu Met Leu Gly Asp Ser Leu Val Leu Lys Gln Asp Ser Pro Tyr Tyr 
385                 390                 395                 400 


Glu His Phe Tyr Met Ala Leu Glu Pro Trp Lys His Tyr Val Pro Ile 
                405                 410                 415     


Lys Arg Asn Leu Ser Asp Leu Leu Glu Lys Val Lys Trp Ala Lys Glu 
            420                 425                 430         


Asn Asp Glu Glu Ala Lys Lys Ile Ala Lys Glu Gly Gln Leu Met Ala 
        435                 440                 445             


Arg Asp Leu Leu Gln Pro His Arg Leu Tyr Cys Tyr Tyr Tyr Gln Val 
    450                 455                 460                 


Leu Gln Lys Tyr Ala Glu Arg Gln Ser Ser Lys Pro Glu Val Arg Asp 
465                 470                 475                 480 


Gly Met Glu Leu Val Pro Gln Pro Glu Asp Ser Thr Ala Ile Cys Gln 
                485                 490                 495     


Cys His Arg Lys Lys Pro Ser Arg Glu Glu Leu 
            500                 505         


<210>  7407
<211>  451
<212>  PRT
<213>  Homo Sapiens

<400>  7407

Met Val Glu Leu Phe Ile Phe Leu Phe Leu Leu Gly Glu Thr Pro Phe 
1               5                   10                  15      


Lys Val Val Val Lys Ser Leu Ser Pro Lys Glu Leu Val Arg Ile His 
            20                  25                  30          


Val Pro Lys Pro Leu Asp Arg Asn Asp Gly Thr Phe Leu Met Arg Tyr 
        35                  40                  45              


Arg Met Tyr Glu Thr Val Asp Glu Gly Leu Lys Ile Glu Val Leu Tyr 
    50                  55                  60                  


Gly Asp Glu His Val Ala Gln Ser Pro Tyr Ile Leu Lys Gly Pro Val 
65                  70                  75                  80  


Tyr His Glu Tyr Cys Glu Cys Pro Glu Asp Pro Gln Ala Trp Gln Lys 
                85                  90                  95      


Thr Leu Ser Cys Pro Thr Lys Glu Pro Gln Ile Ala Lys Asp Phe Ala 
            100                 105                 110         


Ser Phe Pro Ser Ile Asn Leu Gln Gln Met Leu Lys Glu Val Pro Lys 
        115                 120                 125             


Arg Phe Gly Asp Glu Arg Gly Ala Ile Val His Tyr Thr Ile Leu Asn 
    130                 135                 140                 


Asn His Val Tyr Arg Arg Ser Leu Gly Lys Tyr Thr Asp Phe Lys Met 
145                 150                 155                 160 


Phe Ser Asp Glu Ile Leu Leu Ser Leu Thr Arg Lys Val Leu Leu Pro 
                165                 170                 175     


Asp Leu Glu Phe Tyr Val Asn Leu Gly Asp Trp Pro Leu Glu His Arg 
            180                 185                 190         


Lys Val Asn Gly Thr Pro Ser Pro Ile Pro Ile Ile Ser Trp Cys Gly 
        195                 200                 205             


Ser Leu Asp Ser Arg Asp Val Val Leu Pro Thr Tyr Asp Ile Thr His 
    210                 215                 220                 


Ser Met Leu Glu Ala Met Arg Gly Val Thr Asn Asp Leu Leu Ser Ile 
225                 230                 235                 240 


Gln Gly Asn Thr Gly Pro Ser Trp Ile Asn Lys Thr Glu Arg Ala Phe 
                245                 250                 255     


Phe Arg Gly Arg Asp Ser Arg Glu Glu Arg Leu Gln Leu Val Gln Leu 
            260                 265                 270         


Ser Lys Glu Asn Pro Gln Leu Leu Asp Ala Gly Ile Thr Gly Tyr Phe 
        275                 280                 285             


Phe Phe Gln Glu Lys Glu Lys Glu Leu Gly Lys Ala Lys Leu Met Gly 
    290                 295                 300                 


Phe Phe Asp Phe Phe Lys Tyr Lys Tyr Gln Val Asn Val Asp Gly Thr 
305                 310                 315                 320 


Val Ala Ala Tyr Arg Tyr Pro Tyr Leu Met Leu Gly Asp Ser Leu Val 
                325                 330                 335     


Leu Lys Gln Asp Ser Pro Tyr Tyr Glu His Phe Tyr Met Ala Leu Glu 
            340                 345                 350         


Pro Trp Lys His Tyr Val Pro Ile Lys Arg Asn Leu Ser Asp Leu Leu 
        355                 360                 365             


Glu Lys Val Lys Trp Ala Lys Glu Asn Asp Glu Glu Ala Lys Lys Ile 
    370                 375                 380                 


Ala Lys Glu Gly Gln Leu Met Ala Arg Asp Leu Leu Gln Pro His Arg 
385                 390                 395                 400 


Leu Tyr Cys Tyr Tyr Tyr Gln Val Leu Gln Lys Tyr Ala Glu Arg Gln 
                405                 410                 415     


Ser Ser Lys Pro Glu Val Arg Asp Gly Met Glu Leu Val Pro Gln Pro 
            420                 425                 430         


Glu Asp Ser Thr Ala Ile Cys Gln Cys His Arg Lys Lys Pro Ser Arg 
        435                 440                 445             


Glu Glu Leu 
    450     


<210>  7408
<211>  409
<212>  PRT
<213>  Homo Sapiens

<400>  7408

Met Val Glu Leu Phe Ile Phe Leu Phe Leu Leu Gly Glu Thr Pro Phe 
1               5                   10                  15      


Lys Val Val Val Lys Ser Leu Ser Pro Lys Glu Leu Val Arg Ile His 
            20                  25                  30          


Val Pro Lys Pro Leu Asp Arg Asn Asp Gly Thr Phe Leu Met Arg Tyr 
        35                  40                  45              


Arg Met Tyr Glu Thr Val Asp Glu Gly Leu Lys Ile Glu Val Leu Tyr 
    50                  55                  60                  


Gly Asp Glu His Val Ala Gln Ser Pro Tyr Ile Leu Lys Gly Pro Val 
65                  70                  75                  80  


Tyr His Glu Tyr Cys Glu Cys Pro Glu Asp Pro Gln Ala Trp Gln Lys 
                85                  90                  95      


Thr Leu Ser Cys Pro Thr Lys Glu Pro Gln Ile Ala Lys Asp Phe Ala 
            100                 105                 110         


Ser Phe Pro Ser Ile Asn Leu Gln Gln Met Leu Lys Glu Val Pro Lys 
        115                 120                 125             


Arg Phe Gly Asp Glu Arg Gly Ala Ile Val His Tyr Thr Ile Leu Asn 
    130                 135                 140                 


Asn His Val Tyr Arg Arg Ser Leu Gly Lys Tyr Thr Asp Phe Lys Met 
145                 150                 155                 160 


Phe Ser Asp Glu Ile Leu Leu Ser Leu Thr Arg Lys Val Leu Leu Pro 
                165                 170                 175     


Asp Leu Glu Phe Tyr Val Asn Leu Gly Asp Trp Pro Leu Glu His Arg 
            180                 185                 190         


Lys Val Asn Gly Thr Pro Ser Pro Ile Pro Ile Ile Ser Trp Cys Gly 
        195                 200                 205             


Ser Leu Asp Ser Arg Asp Val Val Leu Pro Thr Tyr Asp Ile Thr His 
    210                 215                 220                 


Ser Met Leu Glu Ala Met Arg Gly Val Thr Asn Asp Leu Leu Ser Ile 
225                 230                 235                 240 


Gln Gly Asn Thr Gly Pro Ser Trp Ile Asn Lys Thr Glu Arg Ala Phe 
                245                 250                 255     


Phe Arg Gly Arg Asp Ser Arg Glu Glu Arg Leu Gln Leu Val Gln Leu 
            260                 265                 270         


Ser Lys Glu Asn Pro Gln Leu Leu Asp Ala Gly Ile Thr Gly Tyr Phe 
        275                 280                 285             


Phe Phe Gln Glu Lys Glu Lys Glu Leu Gly Lys Ala Lys Leu Met Gly 
    290                 295                 300                 


Phe Phe Asp Phe Phe Lys Tyr Lys Tyr Gln Val Asn Val Asp Gly Thr 
305                 310                 315                 320 


Val Ala Ala Tyr Arg Tyr Pro Tyr Leu Met Leu Gly Asp Ser Leu Val 
                325                 330                 335     


Leu Lys Gln Asp Ser Pro Tyr Tyr Glu His Phe Tyr Met Ala Leu Glu 
            340                 345                 350         


Pro Trp Lys His Tyr Val Pro Ile Lys Arg Asn Leu Ser Asp Leu Leu 
        355                 360                 365             


Glu Lys Val Lys Trp Ala Lys Ser Phe Thr Leu Ser Pro Arg Leu Glu 
    370                 375                 380                 


Cys Ser Gly Thr Ile Ser Thr His Cys Asn Leu Cys Leu Pro Gly Ser 
385                 390                 395                 400 


Arg Asn Phe Val Pro Gln Pro Pro Glu 
                405                 


<210>  7409
<211>  160
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7409

Xaa Glu Ala Met Arg Gly Val Thr Asn Asp Leu Leu Ser Ile Gln Gly 
1               5                   10                  15      


Asn Thr Gly Pro Ser Trp Ile Asn Lys Thr Glu Arg Ala Phe Phe Arg 
            20                  25                  30          


Gly Arg Asp Ser Arg Glu Glu Arg Leu Gln Leu Val Gln Leu Ser Lys 
        35                  40                  45              


Glu Asn Pro Gln Leu Leu Asp Ala Gly Ile Thr Gly Tyr Phe Phe Phe 
    50                  55                  60                  


Gln Glu Lys Glu Lys Glu Leu Gly Lys Ala Lys Leu Met Gly Phe Phe 
65                  70                  75                  80  


Asp Phe Phe Lys Glu Asn Asp Glu Glu Ala Lys Lys Ile Ala Lys Glu 
                85                  90                  95      


Gly Gln Leu Met Ala Arg Asp Leu Leu Gln Pro His Arg Leu Tyr Cys 
            100                 105                 110         


Tyr Tyr Tyr Gln Val Leu Gln Lys Tyr Ala Glu Arg Gln Ser Ser Lys 
        115                 120                 125             


Pro Glu Val Arg Asp Gly Met Glu Leu Val Pro Gln Pro Glu Asp Ser 
    130                 135                 140                 


Thr Ala Ile Cys Gln Cys His Arg Lys Lys Pro Ser Arg Glu Glu Leu 
145                 150                 155                 160 


<210>  7410
<211>  302
<212>  PRT
<213>  Homo Sapiens

<400>  7410

Asp Phe Glu Phe Thr Gly Ser His Leu Thr Val Arg Asn Gly Tyr Ser 
1               5                   10                  15      


Cys Val Pro Val Ala Leu Ala Glu Gly Leu Asp Ile Lys Leu Asn Thr 
            20                  25                  30          


Ala Val Arg Gln Val Arg Tyr Thr Ala Ser Val Phe Ser His Pro Thr 
        35                  40                  45              


Ser Ala Gly Cys Glu Val Ile Ala Val Asn Thr Arg Ser Thr Ser Gln 
    50                  55                  60                  


Thr Phe Ile Tyr Lys Cys Asp Ala Val Leu Cys Thr Leu Pro Leu Gly 
65                  70                  75                  80  


Val Leu Lys Gln Gln Pro Pro Ala Val Gln Phe Val Pro Pro Leu Pro 
                85                  90                  95      


Glu Trp Lys Thr Ser Ala Val Gln Arg Met Gly Phe Gly Asn Leu Asn 
            100                 105                 110         


Lys Val Val Leu Cys Phe Asp Arg Val Phe Trp Asp Pro Ser Val Asn 
        115                 120                 125             


Leu Phe Gly His Val Gly Ser Thr Thr Ala Ser Arg Gly Glu Leu Phe 
    130                 135                 140                 


Leu Phe Trp Asn Leu Tyr Lys Ala Pro Ile Leu Leu Ala Leu Val Ala 
145                 150                 155                 160 


Gly Glu Ala Ala Gly Ile Met Glu Asn Ile Ser Asp Asp Val Ile Val 
                165                 170                 175     


Gly Arg Cys Leu Ala Ile Leu Lys Gly Ile Phe Gly Ser Ser Ala Val 
            180                 185                 190         


Pro Gln Pro Lys Glu Thr Val Val Ser Arg Trp Arg Ala Asp Pro Trp 
        195                 200                 205             


Ala Arg Gly Ser Tyr Ser Tyr Val Ala Ala Gly Ser Ser Gly Asn Asp 
    210                 215                 220                 


Tyr Asp Leu Met Ala Gln Pro Ile Thr Pro Gly Pro Ser Ile Pro Gly 
225                 230                 235                 240 


Ala Pro Gln Pro Ile Pro Arg Leu Phe Phe Ala Gly Glu His Thr Ile 
                245                 250                 255     


Arg Asn Tyr Pro Ala Thr Val His Gly Ala Leu Leu Ser Gly Leu Arg 
            260                 265                 270         


Glu Ala Gly Arg Ile Ala Asp Gln Phe Leu Gly Ala Met Tyr Thr Leu 
        275                 280                 285             


Pro Arg Gln Ala Thr Pro Gly Val Pro Ala Gln Gln Ser Pro 
    290                 295                 300         


<210>  7411
<211>  876
<212>  PRT
<213>  Homo Sapiens

<400>  7411

Met Leu Ser Gly Lys Lys Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Thr Gly Thr Glu Ala Gly Pro Gly Thr Ala Gly Gly Ser Glu 
            20                  25                  30          


Asn Gly Ser Glu Val Ala Ala Gln Pro Ala Gly Leu Ser Gly Pro Ala 
        35                  40                  45              


Glu Val Gly Pro Gly Ala Val Gly Glu Arg Thr Pro Arg Lys Lys Glu 
    50                  55                  60                  


Pro Pro Arg Ala Ser Pro Pro Gly Gly Leu Ala Glu Pro Pro Gly Ser 
65                  70                  75                  80  


Ala Gly Pro Gln Ala Gly Pro Thr Val Val Pro Gly Ser Ala Thr Pro 
                85                  90                  95      


Met Glu Thr Gly Ile Ala Glu Thr Pro Glu Gly Arg Arg Thr Ser Arg 
            100                 105                 110         


Arg Lys Arg Ala Lys Val Glu Tyr Arg Glu Met Asp Glu Ser Leu Ala 
        115                 120                 125             


Asn Leu Ser Glu Asp Glu Tyr Tyr Ser Glu Glu Glu Arg Asn Ala Lys 
    130                 135                 140                 


Ala Glu Lys Glu Lys Lys Leu Pro Pro Pro Pro Pro Gln Ala Pro Pro 
145                 150                 155                 160 


Glu Glu Glu Asn Glu Ser Glu Pro Glu Glu Pro Ser Gly Gln Ala Gly 
                165                 170                 175     


Gly Leu Gln Asp Asp Ser Ser Gly Gly Tyr Gly Asp Gly Gln Ala Ser 
            180                 185                 190         


Gly Val Glu Gly Ala Ala Phe Gln Ser Arg Leu Pro His Asp Arg Met 
        195                 200                 205             


Thr Ser Gln Glu Ala Ala Cys Phe Pro Asp Ile Ile Ser Gly Pro Gln 
    210                 215                 220                 


Gln Thr Gln Lys Val Phe Leu Phe Ile Arg Asn Arg Thr Leu Gln Leu 
225                 230                 235                 240 


Trp Leu Asp Asn Pro Lys Ile Gln Leu Thr Phe Glu Ala Thr Leu Gln 
                245                 250                 255     


Gln Leu Glu Ala Pro Tyr Asn Ser Asp Thr Val Leu Val His Arg Val 
            260                 265                 270         


His Ser Tyr Leu Glu Arg His Gly Leu Ile Asn Phe Gly Ile Tyr Lys 
        275                 280                 285             


Arg Ile Lys Pro Leu Pro Thr Lys Lys Thr Gly Lys Val Ile Ile Ile 
    290                 295                 300                 


Gly Ser Gly Val Ser Gly Leu Ala Ala Ala Arg Gln Leu Gln Ser Phe 
305                 310                 315                 320 


Gly Met Asp Val Thr Leu Leu Glu Ala Arg Asp Arg Val Gly Gly Arg 
                325                 330                 335     


Val Ala Thr Phe Arg Lys Gly Asn Tyr Val Ala Asp Leu Gly Ala Met 
            340                 345                 350         


Val Val Thr Gly Leu Gly Gly Asn Pro Met Ala Val Val Ser Lys Gln 
        355                 360                 365             


Val Asn Met Glu Leu Ala Lys Ile Lys Gln Lys Cys Pro Leu Tyr Glu 
    370                 375                 380                 


Ala Asn Gly Gln Ala Asp Thr Val Lys Val Pro Lys Glu Lys Asp Glu 
385                 390                 395                 400 


Met Val Glu Gln Glu Phe Asn Arg Leu Leu Glu Ala Thr Ser Tyr Leu 
                405                 410                 415     


Ser His Gln Leu Asp Phe Asn Val Leu Asn Asn Lys Pro Val Ser Leu 
            420                 425                 430         


Gly Gln Ala Leu Glu Val Val Ile Gln Leu Gln Glu Lys His Val Lys 
        435                 440                 445             


Asp Glu Gln Ile Glu His Trp Lys Lys Ile Val Lys Thr Gln Glu Glu 
    450                 455                 460                 


Leu Lys Glu Leu Leu Asn Lys Met Val Asn Leu Lys Glu Lys Ile Lys 
465                 470                 475                 480 


Glu Leu His Gln Gln Tyr Lys Glu Ala Ser Glu Val Lys Pro Pro Arg 
                485                 490                 495     


Asp Ile Thr Ala Glu Phe Leu Val Lys Ser Lys His Arg Asp Leu Thr 
            500                 505                 510         


Ala Leu Cys Lys Glu Tyr Asp Glu Leu Ala Glu Thr Gln Gly Lys Leu 
        515                 520                 525             


Glu Glu Lys Leu Gln Glu Leu Glu Ala Asn Pro Pro Ser Asp Val Tyr 
    530                 535                 540                 


Leu Ser Ser Arg Asp Arg Gln Ile Leu Asp Trp His Phe Ala Asn Leu 
545                 550                 555                 560 


Glu Phe Ala Asn Ala Thr Pro Leu Ser Thr Leu Ser Leu Lys His Trp 
                565                 570                 575     


Asp Gln Asp Asp Asp Phe Glu Phe Thr Gly Ser His Leu Thr Val Arg 
            580                 585                 590         


Asn Gly Tyr Ser Cys Val Pro Val Ala Leu Ala Glu Gly Leu Asp Ile 
        595                 600                 605             


Lys Leu Asn Thr Ala Val Arg Gln Val Arg Tyr Thr Ala Ser Gly Cys 
    610                 615                 620                 


Glu Val Ile Ala Val Asn Thr Arg Ser Thr Ser Gln Thr Phe Ile Tyr 
625                 630                 635                 640 


Lys Cys Asp Ala Val Leu Cys Thr Leu Pro Leu Gly Val Leu Lys Gln 
                645                 650                 655     


Gln Pro Pro Ala Val Gln Phe Val Pro Pro Leu Pro Glu Trp Lys Thr 
            660                 665                 670         


Ser Ala Val Gln Arg Met Gly Phe Gly Asn Leu Asn Lys Val Val Leu 
        675                 680                 685             


Cys Phe Asp Arg Val Phe Trp Asp Pro Ser Val Asn Leu Phe Gly His 
    690                 695                 700                 


Val Gly Ser Thr Thr Ala Ser Arg Gly Glu Leu Phe Leu Phe Trp Asn 
705                 710                 715                 720 


Leu Tyr Lys Ala Pro Ile Leu Leu Ala Leu Val Ala Gly Glu Ala Ala 
                725                 730                 735     


Gly Ile Met Glu Asn Ile Ser Asp Asp Val Ile Val Gly Arg Cys Leu 
            740                 745                 750         


Ala Ile Leu Lys Gly Ile Phe Gly Ser Ser Ala Val Pro Gln Pro Lys 
        755                 760                 765             


Glu Thr Val Val Ser Arg Trp Arg Ala Asp Pro Trp Ala Arg Gly Ser 
    770                 775                 780                 


Tyr Ser Tyr Val Ala Ala Gly Ser Ser Gly Asn Asp Tyr Asp Leu Met 
785                 790                 795                 800 


Ala Gln Pro Ile Thr Pro Gly Pro Ser Ile Pro Gly Ala Pro Gln Pro 
                805                 810                 815     


Ile Pro Arg Leu Phe Phe Ala Gly Glu His Thr Ile Arg Asn Tyr Pro 
            820                 825                 830         


Ala Thr Val His Gly Ala Leu Leu Ser Gly Leu Arg Glu Ala Gly Arg 
        835                 840                 845             


Ile Ala Asp Gln Phe Leu Gly Ala Met Tyr Thr Leu Pro Arg Gln Ala 
    850                 855                 860                 


Thr Pro Gly Val Pro Ala Gln Gln Ser Pro Ser Met 
865                 870                 875     


<210>  7412
<211>  852
<212>  PRT
<213>  Homo Sapiens

<400>  7412

Met Leu Ser Gly Lys Lys Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Thr Gly Thr Glu Ala Gly Pro Gly Thr Ala Gly Gly Ser Glu 
            20                  25                  30          


Asn Gly Ser Glu Val Ala Ala Gln Pro Ala Gly Leu Ser Gly Pro Ala 
        35                  40                  45              


Glu Val Gly Pro Gly Ala Val Gly Glu Arg Thr Pro Arg Lys Lys Glu 
    50                  55                  60                  


Pro Pro Arg Ala Ser Pro Pro Gly Gly Leu Ala Glu Pro Pro Gly Ser 
65                  70                  75                  80  


Ala Gly Pro Gln Ala Gly Pro Thr Val Val Pro Gly Ser Ala Thr Pro 
                85                  90                  95      


Met Glu Thr Gly Ile Ala Glu Thr Pro Glu Gly Arg Arg Thr Ser Arg 
            100                 105                 110         


Arg Lys Arg Ala Lys Val Glu Tyr Arg Glu Met Asp Glu Ser Leu Ala 
        115                 120                 125             


Asn Leu Ser Glu Asp Glu Tyr Tyr Ser Glu Glu Glu Arg Asn Ala Lys 
    130                 135                 140                 


Ala Glu Lys Glu Lys Lys Leu Pro Pro Pro Pro Pro Gln Ala Pro Pro 
145                 150                 155                 160 


Glu Glu Glu Asn Glu Ser Glu Pro Glu Glu Pro Ser Gly Val Glu Gly 
                165                 170                 175     


Ala Ala Phe Gln Ser Arg Leu Pro His Asp Arg Met Thr Ser Gln Glu 
            180                 185                 190         


Ala Ala Cys Phe Pro Asp Ile Ile Ser Gly Pro Gln Gln Thr Gln Lys 
        195                 200                 205             


Val Phe Leu Phe Ile Arg Asn Arg Thr Leu Gln Leu Trp Leu Asp Asn 
    210                 215                 220                 


Pro Lys Ile Gln Leu Thr Phe Glu Ala Thr Leu Gln Gln Leu Glu Ala 
225                 230                 235                 240 


Pro Tyr Asn Ser Asp Thr Val Leu Val His Arg Val His Ser Tyr Leu 
                245                 250                 255     


Glu Arg His Gly Leu Ile Asn Phe Gly Ile Tyr Lys Arg Ile Lys Pro 
            260                 265                 270         


Leu Pro Thr Lys Lys Thr Gly Lys Val Ile Ile Ile Gly Ser Gly Val 
        275                 280                 285             


Ser Gly Leu Ala Ala Ala Arg Gln Leu Gln Ser Phe Gly Met Asp Val 
    290                 295                 300                 


Thr Leu Leu Glu Ala Arg Asp Arg Val Gly Gly Arg Val Ala Thr Phe 
305                 310                 315                 320 


Arg Lys Gly Asn Tyr Val Ala Asp Leu Gly Ala Met Val Val Thr Gly 
                325                 330                 335     


Leu Gly Gly Asn Pro Met Ala Val Val Ser Lys Gln Val Asn Met Glu 
            340                 345                 350         


Leu Ala Lys Ile Lys Gln Lys Cys Pro Leu Tyr Glu Ala Asn Gly Gln 
        355                 360                 365             


Ala Val Pro Lys Glu Lys Asp Glu Met Val Glu Gln Glu Phe Asn Arg 
    370                 375                 380                 


Leu Leu Glu Ala Thr Ser Tyr Leu Ser His Gln Leu Asp Phe Asn Val 
385                 390                 395                 400 


Leu Asn Asn Lys Pro Val Ser Leu Gly Gln Ala Leu Glu Val Val Ile 
                405                 410                 415     


Gln Leu Gln Glu Lys His Val Lys Asp Glu Gln Ile Glu His Trp Lys 
            420                 425                 430         


Lys Ile Val Lys Thr Gln Glu Glu Leu Lys Glu Leu Leu Asn Lys Met 
        435                 440                 445             


Val Asn Leu Lys Glu Lys Ile Lys Glu Leu His Gln Gln Tyr Lys Glu 
    450                 455                 460                 


Ala Ser Glu Val Lys Pro Pro Arg Asp Ile Thr Ala Glu Phe Leu Val 
465                 470                 475                 480 


Lys Ser Lys His Arg Asp Leu Thr Ala Leu Cys Lys Glu Tyr Asp Glu 
                485                 490                 495     


Leu Ala Glu Thr Gln Gly Lys Leu Glu Glu Lys Leu Gln Glu Leu Glu 
            500                 505                 510         


Ala Asn Pro Pro Ser Asp Val Tyr Leu Ser Ser Arg Asp Arg Gln Ile 
        515                 520                 525             


Leu Asp Trp His Phe Ala Asn Leu Glu Phe Ala Asn Ala Thr Pro Leu 
    530                 535                 540                 


Ser Thr Leu Ser Leu Lys His Trp Asp Gln Asp Asp Asp Phe Glu Phe 
545                 550                 555                 560 


Thr Gly Ser His Leu Thr Val Arg Asn Gly Tyr Ser Cys Val Pro Val 
                565                 570                 575     


Ala Leu Ala Glu Gly Leu Asp Ile Lys Leu Asn Thr Ala Val Arg Gln 
            580                 585                 590         


Val Arg Tyr Thr Ala Ser Gly Cys Glu Val Ile Ala Val Asn Thr Arg 
        595                 600                 605             


Ser Thr Ser Gln Thr Phe Ile Tyr Lys Cys Asp Ala Val Leu Cys Thr 
    610                 615                 620                 


Leu Pro Leu Gly Val Leu Lys Gln Gln Pro Pro Ala Val Gln Phe Val 
625                 630                 635                 640 


Pro Pro Leu Pro Glu Trp Lys Thr Ser Ala Val Gln Arg Met Gly Phe 
                645                 650                 655     


Gly Asn Leu Asn Lys Val Val Leu Cys Phe Asp Arg Val Phe Trp Asp 
            660                 665                 670         


Pro Ser Val Asn Leu Phe Gly His Val Gly Ser Thr Thr Ala Ser Arg 
        675                 680                 685             


Gly Glu Leu Phe Leu Phe Trp Asn Leu Tyr Lys Ala Pro Ile Leu Leu 
    690                 695                 700                 


Ala Leu Val Ala Gly Glu Ala Ala Gly Ile Met Glu Asn Ile Ser Asp 
705                 710                 715                 720 


Asp Val Ile Val Gly Arg Cys Leu Ala Ile Leu Lys Gly Ile Phe Gly 
                725                 730                 735     


Ser Ser Ala Val Pro Gln Pro Lys Glu Thr Val Val Ser Arg Trp Arg 
            740                 745                 750         


Ala Asp Pro Trp Ala Arg Gly Ser Tyr Ser Tyr Val Ala Ala Gly Ser 
        755                 760                 765             


Ser Gly Asn Asp Tyr Asp Leu Met Ala Gln Pro Ile Thr Pro Gly Pro 
    770                 775                 780                 


Ser Ile Pro Gly Ala Pro Gln Pro Ile Pro Arg Leu Phe Phe Ala Gly 
785                 790                 795                 800 


Glu His Thr Ile Arg Asn Tyr Pro Ala Thr Val His Gly Ala Leu Leu 
                805                 810                 815     


Ser Gly Leu Arg Glu Ala Gly Arg Ile Ala Asp Gln Phe Leu Gly Ala 
            820                 825                 830         


Met Tyr Thr Leu Pro Arg Gln Ala Thr Pro Gly Val Pro Ala Gln Gln 
        835                 840                 845             


Ser Pro Ser Met 
    850         


<210>  7413
<211>  858
<212>  PRT
<213>  Homo Sapiens

<400>  7413

Met Leu Ser Gly Lys Lys Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Thr Gly Thr Glu Ala Gly Pro Gly Thr Ala Gly Gly Ser Glu 
            20                  25                  30          


Asn Gly Ser Glu Val Ala Ala Gln Pro Ala Gly Leu Ser Gly Pro Ala 
        35                  40                  45              


Glu Val Gly Pro Gly Ala Val Gly Glu Arg Thr Pro Arg Lys Lys Glu 
    50                  55                  60                  


Pro Pro Arg Ala Ser Pro Pro Gly Gly Leu Ala Glu Pro Pro Gly Ser 
65                  70                  75                  80  


Ala Gly Pro Gln Ala Gly Pro Thr Val Val Pro Gly Ser Ala Thr Pro 
                85                  90                  95      


Met Glu Thr Gly Ile Ala Glu Thr Pro Glu Gly Arg Arg Thr Ser Arg 
            100                 105                 110         


Arg Lys Arg Ala Lys Val Glu Tyr Arg Glu Met Asp Glu Ser Leu Ala 
        115                 120                 125             


Asn Leu Ser Glu Asp Glu Tyr Tyr Ser Glu Glu Glu Arg Asn Ala Lys 
    130                 135                 140                 


Ala Glu Lys Glu Lys Lys Leu Pro Pro Pro Pro Pro Gln Ala Pro Pro 
145                 150                 155                 160 


Glu Glu Glu Asn Glu Ser Glu Pro Glu Glu Pro Ser Gly Val Glu Gly 
                165                 170                 175     


Ala Ala Phe Gln Ser Arg Leu Pro His Asp Arg Met Thr Ser Gln Glu 
            180                 185                 190         


Ala Ala Cys Phe Pro Asp Ile Ile Ser Gly Pro Gln Gln Thr Gln Lys 
        195                 200                 205             


Val Phe Leu Phe Ile Arg Asn Arg Thr Leu Gln Leu Trp Leu Asp Asn 
    210                 215                 220                 


Pro Lys Ile Gln Leu Thr Phe Glu Ala Thr Leu Gln Gln Leu Glu Ala 
225                 230                 235                 240 


Pro Tyr Asn Ser Asp Thr Val Leu Val His Arg Val His Ser Tyr Leu 
                245                 250                 255     


Glu Arg His Gly Leu Ile Asn Phe Gly Ile Tyr Lys Arg Ile Lys Pro 
            260                 265                 270         


Leu Pro Thr Lys Lys Thr Gly Lys Val Ile Ile Ile Gly Ser Gly Val 
        275                 280                 285             


Ser Gly Leu Ala Ala Ala Arg Gln Leu Gln Ser Phe Gly Met Asp Val 
    290                 295                 300                 


Thr Leu Leu Glu Ala Arg Asp Arg Val Gly Gly Arg Val Ala Thr Phe 
305                 310                 315                 320 


Arg Lys Gly Asn Tyr Val Ala Asp Leu Gly Ala Met Val Val Thr Gly 
                325                 330                 335     


Leu Gly Gly Asn Pro Met Ala Val Val Ser Lys Gln Val Asn Met Glu 
            340                 345                 350         


Leu Ala Lys Ile Lys Gln Lys Cys Pro Leu Tyr Glu Ala Asn Gly Gln 
        355                 360                 365             


Ala Val Pro Lys Glu Lys Asp Glu Met Val Glu Gln Glu Phe Asn Arg 
    370                 375                 380                 


Leu Leu Glu Ala Thr Ser Tyr Leu Ser His Gln Leu Asp Phe Asn Val 
385                 390                 395                 400 


Leu Asn Asn Lys Pro Val Ser Leu Gly Gln Ala Leu Glu Val Val Ile 
                405                 410                 415     


Gln Leu Gln Glu Lys His Val Lys Asp Glu Gln Ile Glu His Trp Lys 
            420                 425                 430         


Lys Ile Val Lys Thr Gln Glu Glu Leu Lys Glu Leu Leu Asn Lys Met 
        435                 440                 445             


Val Asn Leu Lys Glu Lys Ile Lys Glu Leu His Gln Gln Tyr Lys Glu 
    450                 455                 460                 


Ala Ser Glu Val Lys Pro Pro Arg Asp Ile Thr Ala Glu Phe Leu Val 
465                 470                 475                 480 


Lys Ser Lys His Arg Asp Leu Thr Ala Leu Cys Lys Glu Tyr Asp Glu 
                485                 490                 495     


Leu Ala Glu Thr Gln Gly Lys Leu Glu Glu Lys Leu Gln Glu Leu Glu 
            500                 505                 510         


Ala Asn Pro Pro Ser Pro Leu Phe Phe Cys Ser Asp Val Tyr Leu Ser 
        515                 520                 525             


Ser Arg Asp Arg Gln Ile Leu Asp Trp His Phe Ala Asn Leu Glu Phe 
    530                 535                 540                 


Ala Asn Ala Thr Pro Leu Ser Thr Leu Ser Leu Lys His Trp Asp Gln 
545                 550                 555                 560 


Asp Asp Asp Phe Glu Phe Thr Gly Ser His Leu Thr Val Arg Asn Gly 
                565                 570                 575     


Tyr Ser Cys Val Pro Val Ala Leu Ala Glu Gly Leu Asp Ile Lys Leu 
            580                 585                 590         


Asn Thr Ala Val Arg Gln Val Arg Tyr Thr Ala Ser Gly Cys Glu Val 
        595                 600                 605             


Ile Ala Val Asn Thr Arg Ser Thr Ser Gln Thr Phe Ile Tyr Lys Cys 
    610                 615                 620                 


Asp Ala Val Leu Cys Thr Leu Pro Leu Gly Val Leu Lys Gln Gln Pro 
625                 630                 635                 640 


Pro Ala Val Gln Phe Val Pro Pro Leu Pro Glu Trp Lys Thr Ser Ala 
                645                 650                 655     


Val Gln Arg Met Gly Phe Gly Asn Leu Asn Lys Val Val Leu Cys Phe 
            660                 665                 670         


Asp Arg Val Phe Trp Asp Pro Ser Val Asn Leu Phe Gly His Val Gly 
        675                 680                 685             


Ser Thr Thr Ala Ser Arg Gly Glu Leu Phe Leu Phe Trp Asn Leu Tyr 
    690                 695                 700                 


Lys Ala Pro Ile Leu Leu Ala Leu Val Ala Gly Glu Ala Ala Gly Ile 
705                 710                 715                 720 


Met Glu Asn Ile Ser Asp Asp Val Ile Val Gly Arg Cys Leu Ala Ile 
                725                 730                 735     


Leu Lys Gly Ile Phe Gly Ser Ser Ala Val Pro Gln Pro Lys Glu Thr 
            740                 745                 750         


Val Val Ser Arg Trp Arg Ala Asp Pro Trp Ala Arg Gly Ser Tyr Ser 
        755                 760                 765             


Tyr Val Ala Ala Gly Ser Ser Gly Asn Asp Tyr Asp Leu Met Ala Gln 
    770                 775                 780                 


Pro Ile Thr Pro Gly Pro Ser Ile Pro Gly Ala Pro Gln Pro Ile Pro 
785                 790                 795                 800 


Arg Leu Phe Phe Ala Gly Glu His Thr Ile Arg Asn Tyr Pro Ala Thr 
                805                 810                 815     


Val His Gly Ala Leu Leu Ser Gly Leu Arg Glu Ala Gly Arg Ile Ala 
            820                 825                 830         


Asp Gln Phe Leu Gly Ala Met Tyr Thr Leu Pro Arg Gln Ala Thr Pro 
        835                 840                 845             


Gly Val Pro Ala Gln Gln Ser Pro Ser Met 
    850                 855             


<210>  7414
<211>  274
<212>  PRT
<213>  Homo Sapiens

<400>  7414

Ile Phe Val Glu Phe Asp Gly Cys Asn Trp Lys Gln His Ser Trp Val 
1               5                   10                  15      


Lys Val His Ala Glu Glu Val Ile Val Leu Leu Leu Glu Gly Ser Leu 
            20                  25                  30          


Val Trp Ala Pro Arg Glu Asp Pro Val Leu Leu Gln Gly Ile Arg Val 
        35                  40                  45              


Ser Ile Ala Gln Trp Pro Ala Leu Thr Phe Thr Pro Leu Val Asp Lys 
    50                  55                  60                  


Leu Gly Leu Gly Ser Val Val Pro Val Glu Tyr Leu Leu Asp Arg Glu 
65                  70                  75                  80  


Leu Arg Phe Leu Ser Asp Ala Asn Gly Leu His Leu Phe Gln Met Gly 
                85                  90                  95      


Thr Asp Ser Gln Asn Gln Ile Leu Leu Glu His Ala Ala Leu Arg Glu 
            100                 105                 110         


Thr Val Asn Ala Leu Ile Ser Asp Gln Lys Leu Gln Glu Ile Phe Ser 
        115                 120                 125             


Arg Gly Pro Tyr Ser Val Gln Gly His Arg Val Lys Ile Tyr Gln Pro 
    130                 135                 140                 


Glu Gly Glu Glu Gly Trp Leu Tyr Gly Val Val Ser His Gln Asp Ser 
145                 150                 155                 160 


Ile Thr Arg Leu Met Glu Val Ser Val Thr Glu Ser Gly Glu Ile Lys 
                165                 170                 175     


Ser Val Asp Pro Arg Leu Ile His Val Met Leu Met Asp Asn Ser Ala 
            180                 185                 190         


Pro Gln Ser Glu Gly Gly Thr Leu Lys Ala Val Lys Ser Ser Lys Gly 
        195                 200                 205             


Lys Lys Lys Arg Glu Ser Ile Glu Gly Lys Asp Gly Arg Arg Arg Lys 
    210                 215                 220                 


Ser Ala Ser Asp Ser Gly Cys Asp Pro Ala Ser Lys Lys Leu Lys Gly 
225                 230                 235                 240 


Asp Arg Gly Glu Val Asp Ser Asn Gly Ser Asp Gly Asp Lys Pro Gln 
                245                 250                 255     


His Ser Leu Cys His Leu His Gln Arg Lys Arg Gln Asp Ser Gly Gly 
            260                 265                 270         


Ala Gly 
        


<210>  7415
<211>  1761
<212>  PRT
<213>  Homo Sapiens

<400>  7415

Met Ala Asp Ala Ala Ala Ser Pro Val Gly Lys Arg Leu Leu Leu Leu 
1               5                   10                  15      


Phe Ala Asp Thr Ala Ala Ser Ala Ser Ala Ser Ala Pro Ala Ala Ala 
            20                  25                  30          


Ala Ala Ser Gly Asp Pro Gly Pro Ala Leu Arg Thr Arg Ala Trp Arg 
        35                  40                  45              


Ala Gly Thr Val Arg Ala Met Ser Gly Ala Val Pro Gln Asp Leu Ala 
    50                  55                  60                  


Ile Phe Val Glu Phe Asp Gly Cys Asn Trp Lys Gln His Ser Trp Val 
65                  70                  75                  80  


Lys Val His Ala Glu Glu Val Ile Val Leu Leu Leu Glu Gly Ser Leu 
                85                  90                  95      


Val Trp Ala Pro Arg Glu Asp Pro Val Leu Leu Gln Gly Ile Arg Val 
            100                 105                 110         


Ser Ile Ala Gln Trp Pro Ala Leu Thr Phe Thr Pro Leu Val Asp Lys 
        115                 120                 125             


Leu Gly Leu Gly Ser Val Val Pro Val Glu Tyr Leu Leu Asp Arg Glu 
    130                 135                 140                 


Leu Arg Phe Leu Ser Asp Ala Asn Gly Leu His Leu Phe Gln Met Gly 
145                 150                 155                 160 


Thr Asp Ser Gln Asn Gln Ile Leu Leu Glu His Ala Ala Leu Arg Glu 
                165                 170                 175     


Thr Val Asn Ala Leu Ile Ser Asp Gln Lys Leu Gln Glu Ile Phe Ser 
            180                 185                 190         


Arg Gly Pro Tyr Ser Val Gln Gly His Arg Val Lys Ile Tyr Gln Pro 
        195                 200                 205             


Glu Gly Glu Glu Gly Trp Leu Tyr Gly Val Val Ser His Gln Asp Ser 
    210                 215                 220                 


Ile Thr Arg Leu Met Glu Val Ser Val Thr Glu Ser Gly Glu Ile Lys 
225                 230                 235                 240 


Ser Val Asp Pro Arg Leu Ile His Val Met Leu Met Asp Asn Ser Ala 
                245                 250                 255     


Pro Gln Ser Glu Gly Gly Thr Leu Lys Ala Val Lys Ser Ser Lys Gly 
            260                 265                 270         


Lys Lys Lys Arg Glu Ser Ile Glu Gly Lys Asp Gly Arg Arg Arg Lys 
        275                 280                 285             


Ser Ala Ser Asp Ser Gly Cys Asp Pro Ala Ser Lys Lys Leu Lys Gly 
    290                 295                 300                 


Asp Arg Gly Glu Val Asp Ser Asn Gly Ser Asp Gly Gly Glu Ala Ser 
305                 310                 315                 320 


Arg Gly Pro Trp Lys Gly Gly Asn Ala Ser Gly Glu Pro Gly Leu Asp 
                325                 330                 335     


Gln Arg Ala Lys Gln Pro Pro Ser Thr Phe Val Pro Gln Ile Asn Arg 
            340                 345                 350         


Asn Ile Arg Phe Ala Thr Tyr Thr Lys Glu Asn Gly Arg Thr Leu Val 
        355                 360                 365             


Val Gln Asp Glu Pro Val Gly Gly Asp Thr Pro Ala Ser Phe Thr Pro 
    370                 375                 380                 


Tyr Ser Thr Ala Thr Gly Gln Thr Pro Leu Ala Pro Glu Val Gly Gly 
385                 390                 395                 400 


Ala Glu Asn Lys Glu Ala Gly Lys Thr Leu Glu Gln Val Gly Gln Gly 
                405                 410                 415     


Ile Val Ala Ser Ala Ala Val Val Thr Thr Ala Ser Ser Thr Pro Asn 
            420                 425                 430         


Thr Val Arg Ile Ser Asp Thr Gly Leu Ala Ala Gly Thr Val Pro Glu 
        435                 440                 445             


Lys Gln Lys Gly Ser Arg Ser Gln Ala Ser Gly Glu Asn Ser Arg Asn 
    450                 455                 460                 


Ser Ile Leu Ala Ser Ser Gly Phe Gly Ala Pro Leu Pro Ser Ser Ser 
465                 470                 475                 480 


Gln Pro Leu Thr Phe Gly Ser Gly Arg Ser Gln Ser Asn Gly Val Leu 
                485                 490                 495     


Ala Thr Glu Asn Lys Pro Leu Gly Phe Ser Phe Gly Cys Ser Ser Ala 
            500                 505                 510         


Gln Glu Ala Gln Lys Asp Thr Asp Leu Ser Lys Asn Leu Phe Phe Gln 
        515                 520                 525             


Cys Met Ser Gln Thr Leu Pro Thr Ser Asn Tyr Phe Thr Thr Val Ser 
    530                 535                 540                 


Glu Ser Leu Ala Asp Asp Ser Ser Ser Arg Asp Ser Phe Lys Gln Ser 
545                 550                 555                 560 


Leu Glu Ser Leu Ser Ser Gly Leu Cys Lys Gly Arg Ser Val Leu Gly 
                565                 570                 575     


Thr Asp Thr Lys Pro Gly Ser Lys Ala Gly Ser Ser Val Asp Arg Lys 
            580                 585                 590         


Val Pro Ala Glu Ser Met Pro Thr Leu Thr Pro Ala Phe Pro Arg Ser 
        595                 600                 605             


Leu Leu Asn Ala Arg Thr Pro Glu Asn His Glu Asn Leu Phe Leu Gln 
    610                 615                 620                 


Pro Pro Lys Leu Ser Arg Glu Glu Pro Ser Asn Pro Phe Leu Ala Phe 
625                 630                 635                 640 


Val Glu Lys Val Glu His Ser Pro Phe Ser Ser Phe Ala Ser Gln Ala 
                645                 650                 655     


Ser Gly Ser Ser Ser Ser Ala Thr Thr Val Thr Ser Lys Val Ala Pro 
            660                 665                 670         


Ser Trp Pro Glu Ser His Ser Ser Ala Asp Ser Ala Ser Leu Ala Lys 
        675                 680                 685             


Lys Lys Pro Leu Phe Ile Thr Thr Asp Ser Ser Lys Leu Val Ser Gly 
    690                 695                 700                 


Val Leu Gly Ser Ala Leu Thr Ser Gly Gly Pro Ser Leu Ser Ala Met 
705                 710                 715                 720 


Gly Asn Gly Arg Ser Ser Ser Pro Thr Ser Ser Leu Thr Gln Pro Ile 
                725                 730                 735     


Glu Met Pro Thr Leu Ser Ser Ser Pro Thr Glu Glu Arg Pro Thr Val 
            740                 745                 750         


Gly Pro Gly Gln Gln Asp Asn Pro Leu Leu Lys Thr Phe Ser Asn Val 
        755                 760                 765             


Phe Gly Arg His Ser Gly Gly Phe Leu Ser Ser Pro Ala Asp Phe Ser 
    770                 775                 780                 


Gln Glu Asn Lys Ala Pro Phe Glu Ala Val Lys Arg Phe Ser Leu Asp 
785                 790                 795                 800 


Glu Arg Ser Leu Ala Cys Arg Gln Asp Ser Asp Ser Ser Thr Asn Ser 
                805                 810                 815     


Asp Leu Ser Asp Leu Ser Asp Ser Glu Glu Gln Leu Gln Ala Lys Thr 
            820                 825                 830         


Gly Leu Lys Gly Ile Pro Glu His Leu Met Gly Lys Leu Gly Pro Asn 
        835                 840                 845             


Gly Glu Arg Ser Ala Glu Leu Leu Leu Gly Lys Ser Lys Gly Lys Gln 
    850                 855                 860                 


Ala Pro Lys Gly Arg Pro Arg Thr Ala Pro Leu Lys Val Gly Gln Ser 
865                 870                 875                 880 


Val Leu Lys Asp Val Ser Lys Val Lys Lys Leu Lys Gln Ser Gly Glu 
                885                 890                 895     


Pro Phe Leu Gln Asp Gly Ser Cys Ile Asn Val Ala Pro His Leu His 
            900                 905                 910         


Lys Cys Arg Glu Cys Arg Leu Glu Arg Tyr Arg Lys Phe Lys Glu Gln 
        915                 920                 925             


Glu Gln Asp Asp Ser Thr Val Ala Cys Arg Phe Phe His Phe Arg Arg 
    930                 935                 940                 


Leu Ile Phe Thr Arg Lys Gly Val Leu Arg Val Glu Gly Phe Leu Ser 
945                 950                 955                 960 


Pro Gln Gln Ser Asp Pro Asp Ala Met Asn Leu Trp Ile Pro Ser Ser 
                965                 970                 975     


Ser Leu Ala Glu Gly Ile Asp Leu Glu Thr Ser Lys Tyr Ile Leu Ala 
            980                 985                 990         


Asn Val Gly Asp Gln Phe Cys Gln  Leu Val Met Ser Glu  Lys Glu Ala 
        995                 1000                 1005             


Met Met  Met Val Glu Pro His  Gln Lys Val Ala Trp  Lys Arg Ala 
    1010                 1015                 1020             


Val Arg  Gly Val Arg Glu Met  Cys Asp Val Cys Glu  Thr Thr Leu 
    1025                 1030                 1035             


Phe Asn  Ile His Trp Val Cys  Arg Lys Cys Gly Phe  Gly Val Cys 
    1040                 1045                 1050             


Leu Asp  Cys Tyr Arg Leu Arg  Lys Ser Arg Pro Arg  Ser Glu Thr 
    1055                 1060                 1065             


Glu Glu  Met Gly Asp Glu Glu  Val Phe Ser Trp Leu  Lys Cys Ala 
    1070                 1075                 1080             


Lys Gly  Gln Ser His Glu Pro  Glu Asn Leu Met Pro  Thr Gln Ile 
    1085                 1090                 1095             


Ile Pro  Gly Thr Ala Leu Tyr  Asn Ile Gly Asp Met  Val His Ala 
    1100                 1105                 1110             


Ala Arg  Gly Lys Trp Gly Ile  Lys Ala Asn Cys Pro  Cys Ile Ser 
    1115                 1120                 1125             


Arg Gln  Asn Lys Ser Val Leu  Arg Pro Ala Val Thr  Asn Gly Met 
    1130                 1135                 1140             


Ser Gln  Leu Pro Ser Ile Asn  Pro Ser Ala Ser Ser  Gly Asn Glu 
    1145                 1150                 1155             


Thr Thr  Phe Ser Gly Gly Gly  Gly Pro Ala Pro Val  Thr Thr Pro 
    1160                 1165                 1170             


Glu Pro  Asp His Val Pro Lys  Ala Asp Ser Thr Asp  Ile Arg Ser 
    1175                 1180                 1185             


Glu Glu  Pro Leu Lys Thr Asp  Ser Ser Ala Ser Asn  Ser Asn Ser 
    1190                 1195                 1200             


Glu Leu  Lys Ala Ile Arg Pro  Pro Cys Pro Asp Thr  Ala Pro Pro 
    1205                 1210                 1215             


Ser Ser  Ala Leu His Trp Leu  Ala Asp Leu Ala Thr  Gln Lys Ala 
    1220                 1225                 1230             


Lys Glu  Glu Thr Lys Glu Ala  Gly Ser Leu Arg Ser  Val Leu Asn 
    1235                 1240                 1245             


Lys Glu  Ser His Ser Pro Phe  Gly Leu Asp Ser Phe  Asn Ser Thr 
    1250                 1255                 1260             


Ala Lys  Val Ser Pro Leu Thr  Pro Lys Leu Phe Asn  Ser Leu Leu 
    1265                 1270                 1275             


Leu Gly  Pro Thr Ala Ser Asn  Asn Lys Thr Glu Gly  Ser Ser Leu 
    1280                 1285                 1290             


Arg Asp  Leu Leu His Ser Gly  Pro Gly Lys Leu Pro  Gln Thr Pro 
    1295                 1300                 1305             


Leu Asp  Thr Gly Ile Pro Phe  Pro Pro Val Phe Ser  Thr Ser Ser 
    1310                 1315                 1320             


Ala Gly  Val Lys Ser Lys Ala  Ser Leu Pro Asn Phe  Leu Asp His 
    1325                 1330                 1335             


Ile Ile  Ala Ser Val Val Glu  Asn Lys Lys Thr Ser  Asp Ala Ser 
    1340                 1345                 1350             


Lys Arg  Ala Cys Asn Leu Thr  Asp Thr Gln Lys Glu  Val Lys Glu 
    1355                 1360                 1365             


Met Val  Met Gly Leu Asn Val  Leu Asp Pro His Thr  Ser His Ser 
    1370                 1375                 1380             


Trp Leu  Cys Asp Gly Arg Leu  Leu Cys Leu His Asp  Pro Ser Asn 
    1385                 1390                 1395             


Lys Asn  Asn Trp Lys Ile Phe  Arg Glu Cys Trp Lys  Gln Gly Gln 
    1400                 1405                 1410             


Pro Val  Leu Val Ser Gly Val  His Lys Lys Leu Lys  Ser Glu Leu 
    1415                 1420                 1425             


Trp Lys  Pro Glu Ala Phe Ser  Gln Glu Phe Gly Asp  Gln Asp Val 
    1430                 1435                 1440             


Asp Leu  Val Asn Cys Arg Asn  Cys Ala Ile Ile Ser  Asp Val Lys 
    1445                 1450                 1455             


Val Arg  Asp Phe Trp Asp Gly  Phe Glu Ile Ile Cys  Lys Arg Leu 
    1460                 1465                 1470             


Arg Ser  Glu Asp Gly Gln Pro  Met Val Leu Lys Leu  Lys Asp Trp 
    1475                 1480                 1485             


Pro Pro  Gly Glu Asp Phe Arg  Asp Met Met Pro Thr  Arg Phe Glu 
    1490                 1495                 1500             


Asp Leu  Met Glu Asn Leu Pro  Leu Pro Glu Tyr Thr  Lys Arg Asp 
    1505                 1510                 1515             


Gly Arg  Leu Asn Leu Ala Ser  Arg Leu Pro Ser Tyr  Phe Val Arg 
    1520                 1525                 1530             


Pro Asp  Leu Gly Pro Lys Met  Tyr Asn Ala Tyr Gly  Leu Ile Thr 
    1535                 1540                 1545             


Ala Glu  Asp Arg Arg Val Gly  Thr Thr Asn Leu His  Leu Asp Val 
    1550                 1555                 1560             


Ser Asp  Ala Val Asn Val Met  Val Tyr Val Gly Ile  Pro Ile Gly 
    1565                 1570                 1575             


Glu Gly  Ala His Asp Glu Glu  Val Leu Lys Thr Ile  Asp Glu Gly 
    1580                 1585                 1590             


Asp Ala  Asp Glu Val Thr Lys  Gln Arg Ile His Asp  Gly Lys Glu 
    1595                 1600                 1605             


Lys Pro  Gly Ala Leu Trp His  Ile Tyr Ala Ala Lys  Asp Ala Glu 
    1610                 1615                 1620             


Lys Ile  Arg Glu Leu Leu Arg  Lys Val Gly Glu Glu  Gln Gly Gln 
    1625                 1630                 1635             


Glu Asn  Pro Pro Asp His Asp  Pro Ile His Asp Gln  Ser Trp Tyr 
    1640                 1645                 1650             


Leu Asp  Gln Thr Leu Arg Lys  Arg Leu Tyr Glu Glu  Tyr Gly Val 
    1655                 1660                 1665             


Gln Gly  Trp Ala Ile Val Gln  Phe Leu Gly Asp Ala  Val Phe Ile 
    1670                 1675                 1680             


Pro Ala  Gly Ala Pro His Gln  Val His Asn Leu Tyr  Ser Cys Ile 
    1685                 1690                 1695             


Lys Val  Ala Glu Asp Phe Val  Ser Pro Glu His Val  Lys His Cys 
    1700                 1705                 1710             


Phe Arg  Leu Thr Gln Glu Phe  Arg His Leu Ser Asn  Thr His Thr 
    1715                 1720                 1725             


Asn His  Glu Asp Lys Leu Gln  Val Lys Asn Ile Ile  Tyr His Ala 
    1730                 1735                 1740             


Val Lys  Asp Ala Val Gly Thr  Leu Lys Ala His Glu  Ser Lys Leu 
    1745                 1750                 1755             


Ala Arg  Ser 
    1760     


<210>  7416
<211>  759
<212>  PRT
<213>  Homo Sapiens

<400>  7416

Met Ser Glu Lys Glu Ala Met Met Met Val Glu Pro His Gln Lys Val 
1               5                   10                  15      


Ala Trp Lys Arg Ala Val Arg Gly Val Arg Glu Met Cys Asp Val Cys 
            20                  25                  30          


Glu Thr Thr Leu Phe Asn Ile His Trp Val Cys Arg Lys Cys Gly Phe 
        35                  40                  45              


Gly Val Cys Leu Asp Cys Tyr Arg Leu Arg Lys Ser Arg Pro Arg Ser 
    50                  55                  60                  


Glu Thr Glu Glu Met Gly Asp Glu Glu Val Phe Ser Trp Leu Lys Cys 
65                  70                  75                  80  


Ala Lys Gly Gln Ser His Glu Pro Glu Asn Leu Met Pro Thr Gln Ile 
                85                  90                  95      


Ile Pro Gly Thr Ala Leu Tyr Asn Ile Gly Asp Met Val His Ala Ala 
            100                 105                 110         


Arg Gly Lys Trp Gly Ile Lys Ala Asn Cys Pro Cys Ile Ser Arg Gln 
        115                 120                 125             


Asn Lys Ser Val Leu Arg Pro Ala Val Thr Asn Gly Met Ser Gln Leu 
    130                 135                 140                 


Pro Ser Ile Asn Pro Ser Ala Ser Ser Gly Asn Glu Thr Thr Phe Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Pro Ala Pro Val Thr Thr Pro Glu Pro Asp His Val 
                165                 170                 175     


Pro Lys Ala Asp Ser Thr Asp Ile Arg Ser Glu Glu Pro Leu Lys Thr 
            180                 185                 190         


Asp Ser Ser Ala Ser Asn Ser Asn Ser Glu Leu Lys Ala Ile Arg Pro 
        195                 200                 205             


Pro Cys Pro Asp Thr Ala Pro Pro Ser Ser Ala Leu His Trp Leu Ala 
    210                 215                 220                 


Asp Leu Ala Thr Gln Lys Ala Lys Glu Glu Thr Lys Glu Ala Gly Ser 
225                 230                 235                 240 


Leu Arg Ser Val Leu Asn Lys Glu Ser His Ser Pro Phe Gly Leu Asp 
                245                 250                 255     


Ser Phe Asn Ser Thr Ala Lys Val Ser Pro Leu Thr Pro Lys Leu Phe 
            260                 265                 270         


Asn Ser Leu Leu Leu Gly Pro Thr Ala Ser Asn Asn Lys Thr Glu Gly 
        275                 280                 285             


Ser Ser Leu Arg Asp Leu Leu His Ser Gly Pro Gly Lys Leu Pro Gln 
    290                 295                 300                 


Thr Pro Leu Asp Thr Gly Ile Pro Phe Pro Pro Val Phe Ser Thr Ser 
305                 310                 315                 320 


Ser Ala Gly Val Lys Ser Lys Ala Ser Leu Pro Asn Phe Leu Asp His 
                325                 330                 335     


Ile Ile Ala Ser Val Val Glu Asn Lys Lys Thr Ser Asp Ala Ser Lys 
            340                 345                 350         


Arg Ala Cys Asn Leu Thr Asp Thr Gln Lys Glu Val Lys Glu Met Val 
        355                 360                 365             


Met Gly Leu Asn Val Leu Asp Pro His Thr Ser His Ser Trp Leu Cys 
    370                 375                 380                 


Asp Gly Arg Leu Leu Cys Leu His Asp Pro Ser Asn Lys Asn Asn Trp 
385                 390                 395                 400 


Lys Ile Phe Arg Glu Cys Trp Lys Gln Gly Gln Pro Val Leu Val Ser 
                405                 410                 415     


Gly Val His Lys Lys Leu Lys Ser Glu Leu Trp Lys Pro Glu Ala Phe 
            420                 425                 430         


Ser Gln Glu Phe Gly Asp Gln Asp Val Asp Leu Val Asn Cys Arg Asn 
        435                 440                 445             


Cys Ala Ile Ile Ser Asp Val Lys Val Arg Asp Phe Trp Asp Gly Phe 
    450                 455                 460                 


Glu Ile Ile Cys Lys Arg Leu Arg Ser Glu Asp Gly Gln Pro Met Val 
465                 470                 475                 480 


Leu Lys Leu Lys Asp Trp Pro Pro Gly Glu Asp Phe Arg Asp Met Met 
                485                 490                 495     


Pro Thr Arg Phe Glu Asp Leu Met Glu Asn Leu Pro Leu Pro Glu Tyr 
            500                 505                 510         


Thr Lys Arg Asp Gly Arg Leu Asn Leu Ala Ser Arg Leu Pro Ser Tyr 
        515                 520                 525             


Phe Val Arg Pro Asp Leu Gly Pro Lys Met Tyr Asn Ala Tyr Gly Leu 
    530                 535                 540                 


Ile Thr Ala Glu Asp Arg Arg Val Gly Thr Thr Asn Leu His Leu Asp 
545                 550                 555                 560 


Val Ser Asp Ala Val Asn Val Met Val Tyr Val Gly Ile Pro Ile Gly 
                565                 570                 575     


Glu Gly Ala His Asp Glu Glu Val Leu Lys Thr Ile Asp Glu Gly Asp 
            580                 585                 590         


Ala Asp Glu Val Thr Lys Gln Arg Ile His Asp Gly Lys Glu Lys Pro 
        595                 600                 605             


Gly Ala Leu Trp His Ile Tyr Ala Ala Lys Asp Ala Glu Lys Ile Arg 
    610                 615                 620                 


Glu Leu Leu Arg Lys Val Gly Glu Glu Gln Gly Gln Glu Asn Pro Pro 
625                 630                 635                 640 


Asp His Asp Pro Ile His Asp Gln Ser Trp Tyr Leu Asp Gln Thr Leu 
                645                 650                 655     


Arg Lys Arg Leu Tyr Glu Glu Tyr Gly Val Gln Gly Trp Ala Ile Val 
            660                 665                 670         


Gln Phe Leu Gly Asp Ala Val Phe Ile Pro Ala Gly Ala Pro His Gln 
        675                 680                 685             


Val His Asn Leu Tyr Ser Cys Ile Lys Val Ala Glu Asp Phe Val Ser 
    690                 695                 700                 


Pro Glu His Val Lys His Cys Phe Arg Leu Thr Gln Glu Phe Arg His 
705                 710                 715                 720 


Leu Ser Asn Thr His Thr Asn His Glu Asp Lys Leu Gln Val Lys Asn 
                725                 730                 735     


Ile Ile Tyr His Ala Val Lys Asp Ala Val Gly Thr Leu Lys Ala His 
            740                 745                 750         


Glu Ser Lys Leu Ala Arg Ser 
        755                 


<210>  7417
<211>  20
<212>  PRT
<213>  Homo Sapiens

<400>  7417

Val Pro Glu Lys Gln Lys Gly Ser Arg Ser Gln Ala Ser Gly Glu Leu 
1               5                   10                  15      


Ala Ser Gln Cys 
            20  


<210>  7418
<211>  1384
<212>  PRT
<213>  Homo Sapiens

<400>  7418

Met Ala Ala Gly Lys Ala Ser Gly Glu Ser Glu Glu Ala Ser Pro Ser 
1               5                   10                  15      


Leu Thr Ala Glu Glu Arg Glu Ala Leu Gly Gly Leu Asp Ser Arg Leu 
            20                  25                  30          


Phe Gly Phe Val Arg Phe His Glu Asp Gly Ala Arg Thr Lys Ala Leu 
        35                  40                  45              


Leu Gly Lys Ala Val Arg Cys Tyr Glu Ser Leu Ile Leu Lys Ala Glu 
    50                  55                  60                  


Gly Lys Val Glu Ser Asp Phe Phe Cys Gln Leu Gly His Phe Asn Leu 
65                  70                  75                  80  


Leu Leu Glu Asp Tyr Pro Lys Ala Leu Ser Ala Tyr Gln Arg Tyr Tyr 
                85                  90                  95      


Ser Leu Gln Ser Asp Tyr Trp Lys Asn Ala Ala Phe Leu Tyr Gly Leu 
            100                 105                 110         


Gly Leu Val Tyr Phe His Tyr Asn Ala Phe Gln Trp Ala Ile Lys Ala 
        115                 120                 125             


Phe Gln Glu Val Leu Tyr Val Asp Pro Ser Phe Cys Arg Ala Lys Glu 
    130                 135                 140                 


Ile His Leu Arg Leu Gly Leu Met Phe Lys Val Asn Thr Asp Tyr Glu 
145                 150                 155                 160 


Ser Ser Leu Lys His Phe Gln Leu Ala Leu Val Asp Cys Asn Pro Cys 
                165                 170                 175     


Thr Leu Ser Asn Ala Glu Ile Gln Phe His Ile Ala His Leu Tyr Glu 
            180                 185                 190         


Thr Gln Arg Lys Tyr His Ser Ala Lys Glu Ala Tyr Glu Gln Leu Leu 
        195                 200                 205             


Gln Thr Glu Asn Leu Ser Ala Gln Val Lys Ala Thr Val Leu Gln Gln 
    210                 215                 220                 


Leu Gly Trp Met His His Thr Val Asp Leu Leu Gly Asp Lys Ala Thr 
225                 230                 235                 240 


Lys Glu Ser Tyr Ala Ile Gln Tyr Leu Gln Lys Ser Leu Glu Ala Asp 
                245                 250                 255     


Pro Asn Ser Gly Gln Ser Trp Tyr Phe Leu Gly Arg Cys Tyr Ser Ser 
            260                 265                 270         


Ile Gly Lys Val Gln Asp Ala Phe Ile Ser Tyr Arg Gln Ser Ile Asp 
        275                 280                 285             


Lys Ser Glu Ala Ser Ala Asp Thr Trp Cys Ser Ile Gly Val Leu Tyr 
    290                 295                 300                 


Gln Gln Gln Asn Gln Pro Met Asp Ala Leu Gln Ala Tyr Ile Cys Ala 
305                 310                 315                 320 


Val Gln Leu Asp His Gly His Ala Ala Ala Trp Met Asp Leu Gly Thr 
                325                 330                 335     


Leu Tyr Glu Ser Cys Asn Gln Pro Gln Asp Ala Ile Lys Cys Tyr Leu 
            340                 345                 350         


Asn Ala Thr Arg Ser Lys Ser Cys Ser Asn Thr Ser Ala Leu Ala Ala 
        355                 360                 365             


Arg Ile Lys Tyr Leu Gln Ala Cys Lys Pro His His Pro Asn Thr Glu 
    370                 375                 380                 


Pro Val Leu Gly Leu Ser Gln Thr Pro Ile Ser Gln Gln Ser Leu Pro 
385                 390                 395                 400 


Leu His Met Ile Pro Ser Ser Gln Val Asp Asp Leu Ser Ser Pro Ala 
                405                 410                 415     


Lys Arg Lys Arg Thr Ser Ser Pro Thr Lys Asn Thr Ser Asp Asn Trp 
            420                 425                 430         


Ser Gly Gly His Ala Val Ser His Pro Pro Val Gln Gln Gln Ala His 
        435                 440                 445             


Ser Trp Cys Leu Thr Pro Gln Lys Leu Gln His Leu Glu Gln Leu Arg 
    450                 455                 460                 


Ala Asn Arg Asn Asn Leu Asn Pro Ala Gln Lys Leu Met Leu Glu Gln 
465                 470                 475                 480 


Leu Glu Ser Gln Phe Val Leu Met Gln Gln His Gln Met Arg Pro Thr 
                485                 490                 495     


Gly Val Ala Gln Val Arg Ser Thr Gly Ile Pro Asn Gly Pro Thr Ala 
            500                 505                 510         


Asp Ser Ser Leu Pro Thr Asn Ser Val Ser Gly Gln Gln Pro Gln Leu 
        515                 520                 525             


Ala Leu Thr Arg Val Pro Ser Val Ser Gln Pro Gly Val Arg Pro Ala 
    530                 535                 540                 


Cys Pro Gly Gln Pro Leu Ala Asn Gly Pro Phe Ser Ala Gly His Val 
545                 550                 555                 560 


Pro Cys Ser Thr Ser Arg Thr Leu Gly Ser Thr Asp Thr Ile Leu Ile 
                565                 570                 575     


Gly Asn Asn His Ile Thr Gly Ser Gly Ser Asn Gly Asn Val Pro Tyr 
            580                 585                 590         


Leu Gln Arg Asn Ala Leu Thr Leu Pro His Asn Arg Thr Asn Leu Thr 
        595                 600                 605             


Ser Ser Ala Glu Glu Pro Trp Lys Asn Gln Leu Ser Asn Ser Thr Gln 
    610                 615                 620                 


Gly Leu His Lys Gly Gln Ser Ser His Ser Ala Gly Pro Asn Gly Glu 
625                 630                 635                 640 


Arg Pro Leu Ser Ser Thr Gly Pro Ser Gln His Leu Gln Ala Ala Gly 
                645                 650                 655     


Ser Gly Ile Gln Asn Gln Asn Gly His Pro Thr Leu Pro Ser Asn Ser 
            660                 665                 670         


Val Thr Gln Gly Ala Ala Leu Asn His Leu Ser Ser His Thr Ala Thr 
        675                 680                 685             


Ser Gly Gly Gln Gln Gly Ile Thr Leu Thr Lys Glu Ser Lys Pro Ser 
    690                 695                 700                 


Gly Asn Ile Leu Thr Val Pro Glu Thr Ser Arg His Thr Gly Glu Thr 
705                 710                 715                 720 


Pro Asn Ser Thr Ala Ser Val Glu Gly Leu Pro Asn His Val His Gln 
                725                 730                 735     


Met Thr Ala Asp Ala Val Cys Ser Pro Ser His Gly Asp Ser Lys Ser 
            740                 745                 750         


Pro Gly Leu Leu Ser Ser Asp Asn Pro Gln Leu Ser Ala Leu Leu Met 
        755                 760                 765             


Gly Lys Ala Asn Asn Asn Val Gly Thr Gly Thr Cys Asp Lys Val Asn 
    770                 775                 780                 


Asn Ile His Pro Ala Val His Thr Lys Thr Asp Asn Ser Val Ala Ser 
785                 790                 795                 800 


Ser Pro Ser Ser Ala Ile Ser Thr Ala Thr Pro Ser Pro Lys Ser Thr 
                805                 810                 815     


Glu Gln Thr Thr Thr Asn Ser Val Thr Ser Leu Asn Ser Pro His Ser 
            820                 825                 830         


Gly Leu His Thr Ile Asn Gly Glu Gly Met Glu Glu Ser Gln Ser Pro 
        835                 840                 845             


Met Lys Thr Asp Leu Leu Leu Val Asn His Lys Pro Ser Pro Gln Ile 
    850                 855                 860                 


Ile Pro Ser Met Ser Val Ser Ile Tyr Pro Ser Ser Ala Glu Val Leu 
865                 870                 875                 880 


Lys Ala Cys Arg Asn Leu Gly Lys Asn Gly Leu Ser Asn Ser Ser Ile 
                885                 890                 895     


Leu Leu Asp Lys Cys Pro Pro Pro Arg Pro Pro Ser Ser Pro Tyr Pro 
            900                 905                 910         


Pro Leu Pro Lys Asp Lys Leu Asn Pro Pro Thr Pro Ser Ile Tyr Leu 
        915                 920                 925             


Glu Asn Lys Arg Asp Ala Phe Phe Pro Pro Leu His Gln Phe Cys Thr 
    930                 935                 940                 


Asn Pro Asn Asn Pro Val Thr Val Ile Arg Gly Leu Ala Gly Ala Leu 
945                 950                 955                 960 


Lys Leu Asp Leu Gly Leu Phe Ser Thr Lys Thr Leu Val Glu Ala Asn 
                965                 970                 975     


Asn Glu His Met Val Glu Val Arg Thr Gln Leu Leu Gln Pro Ala Asp 
            980                 985                 990         


Glu Asn Trp Asp Pro Thr Gly Thr  Lys Lys Ile Trp His  Cys Glu Ser 
        995                 1000                 1005             


Asn Arg  Ser His Thr Thr Ile  Ala Lys Tyr Ala Gln  Tyr Gln Ala 
    1010                 1015                 1020             


Ser Ser  Phe Gln Glu Ser Leu  Arg Glu Glu Asn Glu  Lys Arg Ser 
    1025                 1030                 1035             


His His  Lys Asp His Ser Asp  Ser Glu Ser Thr Ser  Ser Asp Asn 
    1040                 1045                 1050             


Ser Gly  Arg Arg Arg Lys Gly  Pro Phe Lys Thr Ile  Lys Phe Gly 
    1055                 1060                 1065             


Thr Asn  Ile Asp Leu Ser Asp  Asp Lys Lys Trp Lys  Leu Gln Leu 
    1070                 1075                 1080             


His Glu  Leu Thr Lys Leu Pro  Ala Phe Val Arg Val  Val Ser Ala 
    1085                 1090                 1095             


Gly Asn  Leu Leu Ser His Val  Gly His Thr Ile Leu  Gly Met Asn 
    1100                 1105                 1110             


Thr Val  Gln Leu Tyr Met Lys  Val Pro Gly Ser Arg  Thr Pro Gly 
    1115                 1120                 1125             


His Gln  Glu Asn Asn Asn Phe  Cys Ser Val Asn Ile  Asn Ile Gly 
    1130                 1135                 1140             


Pro Gly  Asp Cys Glu Trp Phe  Val Val Pro Glu Gly  Tyr Trp Gly 
    1145                 1150                 1155             


Val Leu  Asn Asp Phe Cys Glu  Lys Asn Asn Leu Asn  Phe Leu Met 
    1160                 1165                 1170             


Gly Ser  Trp Trp Pro Asn Leu  Glu Asp Leu Tyr Glu  Ala Asn Val 
    1175                 1180                 1185             


Pro Val  Tyr Arg Phe Ile Gln  Arg Pro Gly Asp Leu  Val Trp Ile 
    1190                 1195                 1200             


Asn Ala  Gly Thr Val His Trp  Val Gln Ala Ile Gly  Trp Cys Asn 
    1205                 1210                 1215             


Asn Ile  Ala Trp Asn Val Gly  Pro Leu Thr Ala Cys  Gln Tyr Lys 
    1220                 1225                 1230             


Leu Ala  Val Glu Arg Tyr Glu  Trp Asn Lys Leu Gln  Ser Val Lys 
    1235                 1240                 1245             


Ser Ile  Val Pro Met Val His  Leu Ser Trp Asn Met  Ala Arg Asn 
    1250                 1255                 1260             


Ile Lys  Val Ser Asp Pro Lys  Leu Phe Glu Met Ile  Lys Tyr Cys 
    1265                 1270                 1275             


Leu Leu  Arg Thr Leu Lys Gln  Cys Gln Thr Leu Arg  Glu Ala Leu 
    1280                 1285                 1290             


Ile Ala  Ala Gly Lys Glu Ile  Ile Trp His Gly Arg  Thr Lys Glu 
    1295                 1300                 1305             


Glu Pro  Ala His Tyr Cys Ser  Ile Cys Glu Val Glu  Val Phe Asp 
    1310                 1315                 1320             


Leu Leu  Phe Val Thr Asn Glu  Ser Asn Ser Arg Lys  Thr Tyr Ile 
    1325                 1330                 1335             


Val His  Cys Gln Asp Cys Ala  Arg Lys Thr Ser Gly  Asn Leu Glu 
    1340                 1345                 1350             


Asn Phe  Val Val Leu Glu Gln  Tyr Lys Met Glu Asp  Leu Met Gln 
    1355                 1360                 1365             


Val Tyr  Asp Gln Phe Thr Leu  Ala Pro Pro Leu Pro  Ser Ala Ser 
    1370                 1375                 1380             


Ser 
    


<210>  7419
<211>  1269
<212>  PRT
<213>  Homo Sapiens

<400>  7419

Met Ala Ala Gly Lys Ala Ser Gly Glu Ser Glu Glu Ala Ser Pro Ser 
1               5                   10                  15      


Leu Thr Ala Glu Glu Arg Glu Ala Leu Gly Gly Leu Asp Ser Arg Leu 
            20                  25                  30          


Phe Gly Phe Val Arg Phe His Glu Asp Gly Ala Arg Thr Lys Ala Leu 
        35                  40                  45              


Leu Gly Lys Ala Val Arg Cys Tyr Glu Ser Leu Ile Leu Lys Ala Glu 
    50                  55                  60                  


Gly Lys Val Glu Ser Asp Phe Phe Cys Gln Leu Gly His Phe Asn Leu 
65                  70                  75                  80  


Leu Leu Glu Asp Tyr Pro Lys Ala Leu Ser Ala Tyr Gln Arg Tyr Tyr 
                85                  90                  95      


Ser Leu Gln Ser Asp Tyr Trp Lys Asn Ala Ala Phe Leu Tyr Gly Leu 
            100                 105                 110         


Gly Leu Val Tyr Phe His Tyr Asn Ala Phe Gln Trp Ala Ile Lys Ala 
        115                 120                 125             


Phe Gln Glu Val Leu Tyr Val Asp Pro Ser Phe Cys Arg Ala Lys Glu 
    130                 135                 140                 


Ile His Leu Arg Leu Gly Leu Met Phe Lys Val Asn Thr Asp Tyr Glu 
145                 150                 155                 160 


Ser Ser Leu Lys His Phe Gln Leu Ala Leu Val Asp Cys Asn Pro Cys 
                165                 170                 175     


Thr Leu Ser Asn Ala Glu Ile Gln Phe His Ile Ala His Leu Tyr Glu 
            180                 185                 190         


Thr Gln Arg Lys Tyr His Ser Ala Lys Glu Ala Tyr Glu Gln Leu Leu 
        195                 200                 205             


Gln Thr Glu Asn Leu Ser Ala Gln Val Lys Ala Thr Val Leu Gln Gln 
    210                 215                 220                 


Leu Gly Trp Met His His Thr Val Asp Leu Leu Gly Asp Lys Ala Thr 
225                 230                 235                 240 


Lys Glu Ser Tyr Ala Ile Gln Tyr Leu Gln Lys Ser Leu Glu Ala Asp 
                245                 250                 255     


Pro Asn Ser Gly Gln Ser Trp Tyr Phe Leu Gly Arg Cys Tyr Ser Ser 
            260                 265                 270         


Ile Gly Lys Val Gln Asp Ala Phe Ile Ser Tyr Arg Gln Ser Ile Asp 
        275                 280                 285             


Lys Ser Glu Ala Ser Ala Asp Thr Trp Cys Ser Ile Gly Val Leu Tyr 
    290                 295                 300                 


Gln Gln Gln Asn Gln Pro Met Asp Ala Leu Gln Ala Tyr Ile Cys Ala 
305                 310                 315                 320 


Val Gln Leu Asp His Gly His Ala Ala Ala Trp Met Asp Leu Gly Thr 
                325                 330                 335     


Leu Tyr Glu Ser Cys Asn Gln Pro Gln Asp Ala Ile Lys Cys Tyr Leu 
            340                 345                 350         


Asn Ala Thr Arg Ser Lys Ser Cys Ser Asn Thr Ser Ala Leu Ala Ala 
        355                 360                 365             


Arg Ile Lys Tyr Leu Gln Ala Cys Lys Pro His His Pro Asn Thr Glu 
    370                 375                 380                 


Pro Val Leu Gly Leu Ser Gln Thr Pro Ile Ser Gln Gln Ser Leu Pro 
385                 390                 395                 400 


Leu His Met Ile Pro Ser Ser Gln Val Asp Asp Leu Ser Ser Pro Ala 
                405                 410                 415     


Lys Arg Lys Arg Thr Ser Ser Pro Thr Lys Asn Thr Ser Asp Asn Trp 
            420                 425                 430         


Ser Gly Gly His Ala Val Ser His Pro Pro Val Gln Gln Gln Ala His 
        435                 440                 445             


Ser Trp Cys Leu Thr Pro Gln Lys Leu Gln Met Arg Pro Thr Gly Val 
    450                 455                 460                 


Ala Gln Val Arg Ser Thr Gly Ile Pro Asn Gly Pro Thr Ala Asp Ser 
465                 470                 475                 480 


Ser Leu Pro Thr Asn Ser Val Ser Gly Gln Gln Pro Gln Leu Ala Leu 
                485                 490                 495     


Thr Arg Val Pro Ser Val Ser Gln Pro Gly Val Arg Pro Ala Cys Pro 
            500                 505                 510         


Gly Gln Pro Leu Ala Asn Gly Pro Phe Ser Ala Gly His Val Pro Cys 
        515                 520                 525             


Ser Thr Ser Arg Thr Leu Gly Ser Thr Asp Thr Ile Leu Ile Gly Asn 
    530                 535                 540                 


Asn His Ile Thr Gly Ser Gly Ser Asn Gly Asn Val Pro Tyr Leu Gln 
545                 550                 555                 560 


Arg Asn Ala Leu Thr Leu Pro His Asn Arg Thr Asn Leu Thr Ser Ser 
                565                 570                 575     


Ala Glu Glu Pro Trp Lys Asn Gln Leu Ser Asn Ser Thr Gln Gly Leu 
            580                 585                 590         


His Lys Gly Gln Ser Ser His Ser Ala Gly Pro Asn Gly Glu Arg Pro 
        595                 600                 605             


Leu Ser Ser Thr Gly Pro Ser Gln His Leu Gln Ala Ala Gly Ser Gly 
    610                 615                 620                 


Ile Gln Asn Gln Asn Gly His Pro Thr Leu Pro Ser Asn Ser Val Thr 
625                 630                 635                 640 


Gln Gly Ala Ala Leu Asn His Leu Ser Ser His Thr Ala Thr Ser Gly 
                645                 650                 655     


Gly Gln Gln Gly Ile Thr Leu Thr Lys Glu Ser Lys Pro Ser Gly Asn 
            660                 665                 670         


Ile Leu Thr Val Pro Glu Thr Ser Arg His Thr Gly Glu Thr Pro Asn 
        675                 680                 685             


Ser Thr Ala Ser Val Glu Gly Leu Pro Asn His Val His Gln Met Thr 
    690                 695                 700                 


Ala Asp Ala Val Cys Ser Pro Ser His Gly Asp Ser Lys Ser Pro Gly 
705                 710                 715                 720 


Leu Leu Ser Ser Asp Asn Pro Gln Leu Ser Ala Leu Leu Met Gly Lys 
                725                 730                 735     


Ala Asn Asn Asn Val Gly Thr Gly Thr Cys Asp Lys Val Asn Asn Ile 
            740                 745                 750         


His Pro Ala Val His Thr Lys Thr Asp Asn Ser Val Ala Ser Ser Pro 
        755                 760                 765             


Ser Ser Ala Ile Ser Thr Ala Thr Pro Ser Pro Lys Ser Thr Glu Gln 
    770                 775                 780                 


Thr Thr Thr Asn Ser Val Thr Ser Leu Asn Ser Pro His Ser Gly Leu 
785                 790                 795                 800 


His Thr Ile Asn Gly Glu Gly Met Glu Glu Ser Gln Ser Pro Met Lys 
                805                 810                 815     


Thr Asp Leu Leu Leu Val Asn His Lys Pro Ser Pro Gln Ile Ile Pro 
            820                 825                 830         


Ser Met Ser Val Ser Ile Tyr Pro Ser Ser Ala Glu Val Leu Lys Ala 
        835                 840                 845             


Cys Arg Asn Leu Gly Lys Asn Gly Leu Ser Asn Ser Ser Ile Leu Leu 
    850                 855                 860                 


Asp Lys Cys Pro Pro Pro Arg Pro Pro Ser Ser Pro Tyr Pro Pro Leu 
865                 870                 875                 880 


Pro Lys Asp Lys Leu Asn Pro Pro Thr Pro Ser Ile Tyr Leu Glu Asn 
                885                 890                 895     


Lys Arg Asp Ala Phe Phe Pro Pro Leu His Gln Phe Cys Thr Asn Pro 
            900                 905                 910         


Asn Asn Pro Val Thr Val Ile Arg Gly Leu Ala Gly Ala Leu Lys Leu 
        915                 920                 925             


Asp Leu Gly Leu Phe Ser Thr Lys Thr Leu Val Glu Ala Asn Asn Glu 
    930                 935                 940                 


His Met Val Glu Val Arg Thr Gln Leu Leu Gln Pro Ala Asp Glu Asn 
945                 950                 955                 960 


Trp Asp Pro Thr Gly Thr Lys Lys Ile Trp His Cys Glu Ser Asn Arg 
                965                 970                 975     


Ser His Thr Thr Ile Ala Lys Tyr Ala Gln Tyr Gln Ala Ser Ser Phe 
            980                 985                 990         


Gln Glu Ser Leu Arg Glu Glu Asn  Glu Lys Arg Ser His  His Lys Asp 
        995                 1000                 1005             


His Ser  Asp Ser Glu Ser Thr  Ser Ser Asp Asn Ser  Gly Arg Arg 
    1010                 1015                 1020             


Arg Lys  Gly Pro Phe Lys Thr  Ile Lys Phe Gly Thr  Asn Ile Asp 
    1025                 1030                 1035             


Leu Ser  Asp Asp Lys Lys Trp  Lys Leu Gln Leu His  Glu Leu Thr 
    1040                 1045                 1050             


Lys Leu  Pro Ala Phe Val Arg  Val Val Ser Ala Gly  Asn Leu Leu 
    1055                 1060                 1065             


Ser His  Val Gly His Thr Ile  Leu Gly Met Asn Thr  Val Gln Leu 
    1070                 1075                 1080             


Tyr Met  Lys Val Pro Gly Ser  Arg Thr Pro Gly His  Gln Glu Asn 
    1085                 1090                 1095             


Asn Asn  Phe Cys Ser Val Asn  Ile Asn Ile Gly Pro  Gly Asp Cys 
    1100                 1105                 1110             


Glu Trp  Phe Val Val Pro Glu  Gly Tyr Trp Gly Val  Leu Asn Asp 
    1115                 1120                 1125             


Phe Cys  Glu Lys Asn Asn Leu  Asn Phe Leu Met Gly  Ser Trp Trp 
    1130                 1135                 1140             


Pro Asn  Leu Glu Asp Leu Tyr  Glu Ala Asn Val Pro  Val Tyr Arg 
    1145                 1150                 1155             


Phe Ile  Gln Arg Pro Gly Asp  Leu Val Trp Ile Asn  Ala Gly Thr 
    1160                 1165                 1170             


Val His  Trp Val Gln Ala Ile  Gly Trp Cys Asn Asn  Ile Ala Trp 
    1175                 1180                 1185             


Asn Val  Gly Pro Leu Thr Ala  Cys Gln Tyr Lys Leu  Ala Val Glu 
    1190                 1195                 1200             


Arg Tyr  Glu Trp Asn Lys Leu  Gln Ser Val Lys Ser  Ile Val Pro 
    1205                 1210                 1215             


Met Val  His Leu Ser Trp Asn  Met Ala Arg Asn Ile  Lys Val Leu 
    1220                 1225                 1230             


Ser Ser  Lys Asn Ser Glu Ala  Met Ser Asp Ile Glu  Gly Ser Ser 
    1235                 1240                 1245             


His Cys  Cys Arg Lys Arg Asp  Tyr Met Ala Trp Ala  Asp Lys Arg 
    1250                 1255                 1260             


Arg Thr  Ser Ser Leu Leu 
    1265                 


<210>  7420
<211>  1332
<212>  PRT
<213>  Homo Sapiens

<400>  7420

Met Ala Ala Gly Lys Ala Ser Gly Glu Ser Glu Glu Ala Ser Pro Ser 
1               5                   10                  15      


Leu Thr Ala Glu Glu Arg Glu Ala Leu Gly Gly Leu Asp Ser Arg Leu 
            20                  25                  30          


Phe Gly Phe Val Arg Phe His Glu Asp Gly Ala Arg Thr Lys Ala Leu 
        35                  40                  45              


Leu Gly Lys Ala Val Arg Cys Tyr Glu Ser Leu Ile Leu Lys Ala Glu 
    50                  55                  60                  


Gly Lys Val Glu Ser Asp Phe Phe Cys Gln Leu Gly His Phe Asn Leu 
65                  70                  75                  80  


Leu Leu Glu Asp Tyr Pro Lys Ala Leu Ser Ala Tyr Gln Arg Tyr Tyr 
                85                  90                  95      


Ser Leu Gln Ser Asp Tyr Trp Lys Asn Ala Ala Phe Leu Tyr Gly Leu 
            100                 105                 110         


Gly Leu Val Tyr Phe His Tyr Asn Ala Phe Gln Trp Ala Ile Lys Ala 
        115                 120                 125             


Phe Gln Glu Val Leu Tyr Val Asp Pro Ser Phe Cys Arg Ala Lys Glu 
    130                 135                 140                 


Ile His Leu Arg Leu Gly Leu Met Phe Lys Val Asn Thr Asp Tyr Glu 
145                 150                 155                 160 


Ser Ser Leu Lys His Phe Gln Leu Ala Leu Val Asp Cys Asn Pro Cys 
                165                 170                 175     


Thr Leu Ser Asn Ala Glu Ile Gln Phe His Ile Ala His Leu Tyr Glu 
            180                 185                 190         


Thr Gln Arg Lys Tyr His Ser Ala Lys Glu Ala Tyr Glu Gln Leu Leu 
        195                 200                 205             


Gln Thr Glu Asn Leu Ser Ala Gln Val Lys Ala Thr Val Leu Gln Gln 
    210                 215                 220                 


Leu Gly Trp Met His His Thr Val Asp Leu Leu Gly Asp Lys Ala Thr 
225                 230                 235                 240 


Lys Glu Ser Tyr Ala Ile Gln Tyr Leu Gln Lys Ser Leu Glu Ala Asp 
                245                 250                 255     


Pro Asn Ser Gly Gln Ser Trp Tyr Phe Leu Gly Arg Cys Tyr Ser Ser 
            260                 265                 270         


Ile Gly Lys Val Gln Asp Ala Phe Ile Ser Tyr Arg Gln Ser Ile Asp 
        275                 280                 285             


Lys Ser Glu Ala Ser Ala Asp Thr Trp Cys Ser Ile Gly Val Leu Tyr 
    290                 295                 300                 


Gln Gln Gln Asn Gln Pro Met Asp Ala Leu Gln Ala Tyr Ile Cys Ala 
305                 310                 315                 320 


Val Gln Leu Asp His Gly His Ala Ala Ala Trp Met Asp Leu Gly Thr 
                325                 330                 335     


Leu Tyr Glu Ser Cys Asn Gln Pro Gln Asp Ala Ile Lys Cys Tyr Leu 
            340                 345                 350         


Asn Ala Thr Arg Ser Lys Ser Cys Ser Asn Thr Ser Ala Leu Ala Ala 
        355                 360                 365             


Arg Ile Lys Tyr Leu Gln Asn Thr Ser Asp Asn Trp Ser Gly Gly His 
    370                 375                 380                 


Ala Val Ser His Pro Pro Val Gln Gln Gln Ala His Ser Trp Cys Leu 
385                 390                 395                 400 


Thr Pro Gln Lys Leu Gln His Leu Glu Gln Leu Arg Ala Asn Arg Asn 
                405                 410                 415     


Asn Leu Asn Pro Ala Gln Lys Leu Met Leu Glu Gln Leu Glu Ser Gln 
            420                 425                 430         


Phe Val Leu Met Gln Gln His Gln Met Arg Pro Thr Gly Val Ala Gln 
        435                 440                 445             


Val Arg Ser Thr Gly Ile Pro Asn Gly Pro Thr Ala Asp Ser Ser Leu 
    450                 455                 460                 


Pro Thr Asn Ser Val Ser Gly Gln Gln Pro Gln Leu Ala Leu Thr Arg 
465                 470                 475                 480 


Val Pro Ser Val Ser Gln Pro Gly Val Arg Pro Ala Cys Pro Gly Gln 
                485                 490                 495     


Pro Leu Ala Asn Gly Pro Phe Ser Ala Gly His Val Pro Cys Ser Thr 
            500                 505                 510         


Ser Arg Thr Leu Gly Ser Thr Asp Thr Ile Leu Ile Gly Asn Asn His 
        515                 520                 525             


Ile Thr Gly Ser Gly Ser Asn Gly Asn Val Pro Tyr Leu Gln Arg Asn 
    530                 535                 540                 


Ala Leu Thr Leu Pro His Asn Arg Thr Asn Leu Thr Ser Ser Ala Glu 
545                 550                 555                 560 


Glu Pro Trp Lys Asn Gln Leu Ser Asn Ser Thr Gln Gly Leu His Lys 
                565                 570                 575     


Gly Gln Ser Ser His Ser Ala Gly Pro Asn Gly Glu Arg Pro Leu Ser 
            580                 585                 590         


Ser Thr Gly Pro Ser Gln His Leu Gln Ala Ala Gly Ser Gly Ile Gln 
        595                 600                 605             


Asn Gln Asn Gly His Pro Thr Leu Pro Ser Asn Ser Val Thr Gln Gly 
    610                 615                 620                 


Ala Ala Leu Asn His Leu Ser Ser His Thr Ala Thr Ser Gly Gly Gln 
625                 630                 635                 640 


Gln Gly Ile Thr Leu Thr Lys Glu Ser Lys Pro Ser Gly Asn Ile Leu 
                645                 650                 655     


Thr Val Pro Glu Thr Ser Arg His Thr Gly Glu Thr Pro Asn Ser Thr 
            660                 665                 670         


Ala Ser Val Glu Gly Leu Pro Asn His Val His Gln Met Thr Ala Asp 
        675                 680                 685             


Ala Val Cys Ser Pro Ser His Gly Asp Ser Lys Ser Pro Gly Leu Leu 
    690                 695                 700                 


Ser Ser Asp Asn Pro Gln Leu Ser Ala Leu Leu Met Gly Lys Ala Asn 
705                 710                 715                 720 


Asn Asn Val Gly Thr Gly Thr Cys Asp Lys Val Asn Asn Ile His Pro 
                725                 730                 735     


Ala Val His Thr Lys Thr Asp Asn Ser Val Ala Ser Ser Pro Ser Ser 
            740                 745                 750         


Ala Ile Ser Thr Ala Thr Pro Ser Pro Lys Ser Thr Glu Gln Thr Thr 
        755                 760                 765             


Thr Asn Ser Val Thr Ser Leu Asn Ser Pro His Ser Gly Leu His Thr 
    770                 775                 780                 


Ile Asn Gly Glu Gly Met Glu Glu Ser Gln Ser Pro Met Lys Thr Asp 
785                 790                 795                 800 


Leu Leu Leu Val Asn His Lys Pro Ser Pro Gln Ile Ile Pro Ser Met 
                805                 810                 815     


Ser Val Ser Ile Tyr Pro Ser Ser Ala Glu Val Leu Lys Ala Cys Arg 
            820                 825                 830         


Asn Leu Gly Lys Asn Gly Leu Ser Asn Ser Ser Ile Leu Leu Asp Lys 
        835                 840                 845             


Cys Pro Pro Pro Arg Pro Pro Ser Ser Pro Tyr Pro Pro Leu Pro Lys 
    850                 855                 860                 


Asp Lys Leu Asn Pro Pro Thr Pro Ser Ile Tyr Leu Glu Asn Lys Arg 
865                 870                 875                 880 


Asp Ala Phe Phe Pro Pro Leu His Gln Phe Cys Thr Asn Pro Asn Asn 
                885                 890                 895     


Pro Val Thr Val Ile Arg Gly Leu Ala Gly Ala Leu Lys Leu Asp Leu 
            900                 905                 910         


Gly Leu Phe Ser Thr Lys Thr Leu Val Glu Ala Asn Asn Glu His Met 
        915                 920                 925             


Val Glu Val Arg Thr Gln Leu Leu Gln Pro Ala Asp Glu Asn Trp Asp 
    930                 935                 940                 


Pro Thr Gly Thr Lys Lys Ile Trp His Cys Glu Ser Asn Arg Ser His 
945                 950                 955                 960 


Thr Thr Ile Ala Lys Tyr Ala Gln Tyr Gln Ala Ser Ser Phe Gln Glu 
                965                 970                 975     


Ser Leu Arg Glu Glu Asn Glu Lys Arg Ser His His Lys Asp His Ser 
            980                 985                 990         


Asp Ser Glu Ser Thr Ser Ser Asp  Asn Ser Gly Arg Arg  Arg Lys Gly 
        995                 1000                 1005             


Pro Phe  Lys Thr Ile Lys Phe  Gly Thr Asn Ile Asp  Leu Ser Asp 
    1010                 1015                 1020             


Asp Lys  Lys Trp Lys Leu Gln  Leu His Glu Leu Thr  Lys Leu Pro 
    1025                 1030                 1035             


Ala Phe  Val Arg Val Val Ser  Ala Gly Asn Leu Leu  Ser His Val 
    1040                 1045                 1050             


Gly His  Thr Ile Leu Gly Met  Asn Thr Val Gln Leu  Tyr Met Lys 
    1055                 1060                 1065             


Val Pro  Gly Ser Arg Thr Pro  Gly His Gln Glu Asn  Asn Asn Phe 
    1070                 1075                 1080             


Cys Ser  Val Asn Ile Asn Ile  Gly Pro Gly Asp Cys  Glu Trp Phe 
    1085                 1090                 1095             


Val Val  Pro Glu Gly Tyr Trp  Gly Val Leu Asn Asp  Phe Cys Glu 
    1100                 1105                 1110             


Lys Asn  Asn Leu Asn Phe Leu  Met Gly Ser Trp Trp  Pro Asn Leu 
    1115                 1120                 1125             


Glu Asp  Leu Tyr Glu Ala Asn  Val Pro Val Tyr Arg  Phe Ile Gln 
    1130                 1135                 1140             


Arg Pro  Gly Asp Leu Val Trp  Ile Asn Ala Gly Thr  Val His Trp 
    1145                 1150                 1155             


Val Gln  Ala Ile Gly Trp Cys  Asn Asn Ile Ala Trp  Asn Val Gly 
    1160                 1165                 1170             


Pro Leu  Thr Ala Cys Gln Tyr  Lys Leu Ala Val Glu  Arg Tyr Glu 
    1175                 1180                 1185             


Trp Asn  Lys Leu Gln Ser Val  Lys Ser Ile Val Pro  Met Val His 
    1190                 1195                 1200             


Leu Ser  Trp Asn Met Ala Arg  Asn Ile Lys Val Ser  Asp Pro Lys 
    1205                 1210                 1215             


Leu Phe  Glu Met Ile Lys Tyr  Cys Leu Leu Arg Thr  Leu Lys Gln 
    1220                 1225                 1230             


Cys Gln  Thr Leu Arg Glu Ala  Leu Ile Ala Ala Gly  Lys Glu Ile 
    1235                 1240                 1245             


Ile Trp  His Gly Arg Thr Lys  Glu Glu Pro Ala His  Tyr Cys Ser 
    1250                 1255                 1260             


Ile Cys  Glu Val Glu Val Phe  Asp Leu Leu Phe Val  Thr Asn Glu 
    1265                 1270                 1275             


Ser Asn  Ser Arg Lys Thr Tyr  Ile Val His Cys Gln  Asp Cys Ala 
    1280                 1285                 1290             


Arg Lys  Thr Ser Gly Asn Leu  Glu Asn Phe Val Val  Leu Glu Gln 
    1295                 1300                 1305             


Tyr Lys  Met Glu Asp Leu Met  Gln Val Tyr Asp Gln  Phe Thr Leu 
    1310                 1315                 1320             


Ala Pro  Pro Leu Pro Ser Ala  Ser Ser 
    1325                 1330         


<210>  7421
<211>  1429
<212>  PRT
<213>  Homo Sapiens

<400>  7421

Met Ala Ala Gly Lys Ala Ser Gly Glu Ser Glu Glu Ala Ser Pro Ser 
1               5                   10                  15      


Leu Thr Ala Glu Glu Arg Glu Ala Leu Gly Gly Leu Asp Ser Arg Leu 
            20                  25                  30          


Phe Gly Phe Val Arg Phe His Glu Asp Gly Ala Arg Thr Lys Ala Leu 
        35                  40                  45              


Leu Gly Lys Ala Val Arg Cys Tyr Glu Ser Leu Ile Leu Lys Ala Glu 
    50                  55                  60                  


Gly Lys Val Glu Ser Asp Phe Phe Cys Gln Leu Gly His Phe Asn Leu 
65                  70                  75                  80  


Leu Leu Glu Asp Tyr Pro Lys Ala Leu Ser Ala Tyr Gln Arg Tyr Tyr 
                85                  90                  95      


Ser Leu Gln Ser Asp Tyr Trp Lys Asn Ala Ala Phe Leu Tyr Gly Leu 
            100                 105                 110         


Gly Leu Val Tyr Phe His Tyr Asn Ala Phe Gln Trp Ala Ile Lys Ala 
        115                 120                 125             


Phe Gln Glu Val Leu Tyr Val Asp Pro Ser Phe Cys Arg Ala Lys Glu 
    130                 135                 140                 


Ile His Leu Arg Leu Gly Leu Met Phe Lys Val Asn Thr Asp Tyr Glu 
145                 150                 155                 160 


Ser Ser Leu Lys His Phe Gln Leu Ala Leu Val Asp Cys Asn Pro Cys 
                165                 170                 175     


Thr Leu Ser Asn Ala Glu Ile Gln Phe His Ile Ala His Leu Tyr Glu 
            180                 185                 190         


Thr Gln Arg Lys Tyr His Ser Ala Lys Glu Ala Tyr Glu Gln Leu Leu 
        195                 200                 205             


Gln Thr Glu Asn Leu Ser Ala Gln Val Lys Ala Thr Val Leu Gln Gln 
    210                 215                 220                 


Leu Gly Trp Met His His Thr Val Asp Leu Leu Gly Asp Lys Ala Thr 
225                 230                 235                 240 


Lys Glu Ser Tyr Ala Ile Gln Tyr Leu Gln Lys Ser Leu Glu Ala Asp 
                245                 250                 255     


Pro Asn Ser Gly Gln Ser Trp Tyr Phe Leu Gly Arg Cys Tyr Ser Ser 
            260                 265                 270         


Ile Gly Lys Val Gln Asp Ala Phe Ile Ser Tyr Arg Gln Ser Ile Asp 
        275                 280                 285             


Lys Ser Glu Ala Ser Ala Asp Thr Trp Cys Ser Ile Gly Val Leu Tyr 
    290                 295                 300                 


Gln Gln Gln Asn Gln Pro Met Asp Ala Leu Gln Ala Tyr Ile Cys Ala 
305                 310                 315                 320 


Val Gln Leu Asp His Gly His Ala Ala Ala Trp Met Asp Leu Gly Thr 
                325                 330                 335     


Leu Tyr Glu Ser Cys Asn Gln Pro Gln Asp Ala Ile Lys Cys Tyr Leu 
            340                 345                 350         


Asn Ala Thr Arg Ser Lys Ser Cys Ser Asn Thr Ser Ala Leu Ala Ala 
        355                 360                 365             


Arg Ile Lys Tyr Leu Gln Ala Gln Leu Cys Asn Leu Pro Gln Gly Ser 
    370                 375                 380                 


Leu Gln Asn Lys Thr Lys Leu Leu Pro Ser Ile Glu Glu Ala Trp Ser 
385                 390                 395                 400 


Leu Pro Ile Pro Ala Glu Leu Thr Ser Arg Gln Gly Ala Met Asn Thr 
                405                 410                 415     


Ala Gln Gln Ala Cys Lys Pro His His Pro Asn Thr Glu Pro Val Leu 
            420                 425                 430         


Gly Leu Ser Gln Thr Pro Ile Ser Gln Gln Ser Leu Pro Leu His Met 
        435                 440                 445             


Ile Pro Ser Ser Gln Val Asp Asp Leu Ser Ser Pro Ala Lys Arg Lys 
    450                 455                 460                 


Arg Thr Ser Ser Pro Thr Lys Asn Thr Ser Asp Asn Trp Ser Gly Gly 
465                 470                 475                 480 


His Ala Val Ser His Pro Pro Val Gln Gln Gln Ala His Ser Trp Cys 
                485                 490                 495     


Leu Thr Pro Gln Lys Leu Gln His Leu Glu Gln Leu Arg Ala Asn Arg 
            500                 505                 510         


Asn Asn Leu Asn Pro Ala Gln Lys Leu Met Leu Glu Gln Leu Glu Ser 
        515                 520                 525             


Gln Phe Val Leu Met Gln Gln His Gln Met Arg Pro Thr Gly Val Ala 
    530                 535                 540                 


Gln Val Arg Ser Thr Gly Ile Pro Asn Gly Pro Thr Ala Asp Ser Ser 
545                 550                 555                 560 


Leu Pro Thr Asn Ser Val Ser Gly Gln Gln Pro Gln Leu Ala Leu Thr 
                565                 570                 575     


Arg Val Pro Ser Val Ser Gln Pro Gly Val Arg Pro Ala Cys Pro Gly 
            580                 585                 590         


Gln Pro Leu Ala Asn Gly Pro Phe Ser Ala Gly His Val Pro Cys Ser 
        595                 600                 605             


Thr Ser Arg Thr Leu Gly Ser Thr Asp Thr Ile Leu Ile Gly Asn Asn 
    610                 615                 620                 


His Ile Thr Gly Ser Gly Ser Asn Gly Asn Val Pro Tyr Leu Gln Arg 
625                 630                 635                 640 


Asn Ala Leu Thr Leu Pro His Asn Arg Thr Asn Leu Thr Ser Ser Ala 
                645                 650                 655     


Glu Glu Pro Trp Lys Asn Gln Leu Ser Asn Ser Thr Gln Gly Leu His 
            660                 665                 670         


Lys Gly Gln Ser Ser His Ser Ala Gly Pro Asn Gly Glu Arg Pro Leu 
        675                 680                 685             


Ser Ser Thr Gly Pro Ser Gln His Leu Gln Ala Ala Gly Ser Gly Ile 
    690                 695                 700                 


Gln Asn Gln Asn Gly His Pro Thr Leu Pro Ser Asn Ser Val Thr Gln 
705                 710                 715                 720 


Gly Ala Ala Leu Asn His Leu Ser Ser His Thr Ala Thr Ser Gly Gly 
                725                 730                 735     


Gln Gln Gly Ile Thr Leu Thr Lys Glu Ser Lys Pro Ser Gly Asn Ile 
            740                 745                 750         


Leu Thr Val Pro Glu Thr Ser Arg His Thr Gly Glu Thr Pro Asn Ser 
        755                 760                 765             


Thr Ala Ser Val Glu Gly Leu Pro Asn His Val His Gln Met Thr Ala 
    770                 775                 780                 


Asp Ala Val Cys Ser Pro Ser His Gly Asp Ser Lys Ser Pro Gly Leu 
785                 790                 795                 800 


Leu Ser Ser Asp Asn Pro Gln Leu Ser Ala Leu Leu Met Gly Lys Ala 
                805                 810                 815     


Asn Asn Asn Val Gly Thr Gly Thr Cys Asp Lys Val Asn Asn Ile His 
            820                 825                 830         


Pro Ala Val His Thr Lys Thr Asp Asn Ser Val Ala Ser Ser Pro Ser 
        835                 840                 845             


Ser Ala Ile Ser Thr Ala Thr Pro Ser Pro Lys Ser Thr Glu Gln Thr 
    850                 855                 860                 


Thr Thr Asn Ser Val Thr Ser Leu Asn Ser Pro His Ser Gly Leu His 
865                 870                 875                 880 


Thr Ile Asn Gly Glu Gly Met Glu Glu Ser Gln Ser Pro Met Lys Thr 
                885                 890                 895     


Asp Leu Leu Leu Val Asn His Lys Pro Ser Pro Gln Ile Ile Pro Ser 
            900                 905                 910         


Met Ser Val Ser Ile Tyr Pro Ser Ser Ala Glu Val Leu Lys Ala Cys 
        915                 920                 925             


Arg Asn Leu Gly Lys Asn Gly Leu Ser Asn Ser Ser Ile Leu Leu Asp 
    930                 935                 940                 


Lys Cys Pro Pro Pro Arg Pro Pro Ser Ser Pro Tyr Pro Pro Leu Pro 
945                 950                 955                 960 


Lys Asp Lys Leu Asn Pro Pro Thr Pro Ser Ile Tyr Leu Glu Asn Lys 
                965                 970                 975     


Arg Asp Ala Phe Phe Pro Pro Leu His Gln Phe Cys Thr Asn Pro Asn 
            980                 985                 990         


Asn Pro Val Thr Val Ile Arg Gly  Leu Ala Gly Ala Leu  Lys Leu Asp 
        995                 1000                 1005             


Leu Gly  Leu Phe Ser Thr Lys  Thr Leu Val Glu Ala  Asn Asn Glu 
    1010                 1015                 1020             


His Met  Val Glu Val Arg Thr  Gln Leu Leu Gln Pro  Ala Asp Glu 
    1025                 1030                 1035             


Asn Trp  Asp Pro Thr Gly Thr  Lys Lys Ile Trp His  Cys Glu Ser 
    1040                 1045                 1050             


Asn Arg  Ser His Thr Thr Ile  Ala Lys Tyr Ala Gln  Tyr Gln Ala 
    1055                 1060                 1065             


Ser Ser  Phe Gln Glu Ser Leu  Arg Glu Glu Asn Glu  Lys Arg Ser 
    1070                 1075                 1080             


His His  Lys Asp His Ser Asp  Ser Glu Ser Thr Ser  Ser Asp Asn 
    1085                 1090                 1095             


Ser Gly  Arg Arg Arg Lys Gly  Pro Phe Lys Thr Ile  Lys Phe Gly 
    1100                 1105                 1110             


Thr Asn  Ile Asp Leu Ser Asp  Asp Lys Lys Trp Lys  Leu Gln Leu 
    1115                 1120                 1125             


His Glu  Leu Thr Lys Leu Pro  Ala Phe Val Arg Val  Val Ser Ala 
    1130                 1135                 1140             


Gly Asn  Leu Leu Ser His Val  Gly His Thr Ile Leu  Gly Met Asn 
    1145                 1150                 1155             


Thr Val  Gln Leu Tyr Met Lys  Val Pro Gly Ser Arg  Thr Pro Gly 
    1160                 1165                 1170             


His Gln  Glu Asn Asn Asn Phe  Cys Ser Val Asn Ile  Asn Ile Gly 
    1175                 1180                 1185             


Pro Gly  Asp Cys Glu Trp Phe  Val Val Pro Glu Gly  Tyr Trp Gly 
    1190                 1195                 1200             


Val Leu  Asn Asp Phe Cys Glu  Lys Asn Asn Leu Asn  Phe Leu Met 
    1205                 1210                 1215             


Gly Ser  Trp Trp Pro Asn Leu  Glu Asp Leu Tyr Glu  Ala Asn Val 
    1220                 1225                 1230             


Pro Val  Tyr Arg Phe Ile Gln  Arg Pro Gly Asp Leu  Val Trp Ile 
    1235                 1240                 1245             


Asn Ala  Gly Thr Val His Trp  Val Gln Ala Ile Gly  Trp Cys Asn 
    1250                 1255                 1260             


Asn Ile  Ala Trp Asn Val Gly  Pro Leu Thr Ala Cys  Gln Tyr Lys 
    1265                 1270                 1275             


Leu Ala  Val Glu Arg Tyr Glu  Trp Asn Lys Leu Gln  Ser Val Lys 
    1280                 1285                 1290             


Ser Ile  Val Pro Met Val His  Leu Ser Trp Asn Met  Ala Arg Asn 
    1295                 1300                 1305             


Ile Lys  Val Ser Asp Pro Lys  Leu Phe Glu Met Ile  Lys Tyr Cys 
    1310                 1315                 1320             


Leu Leu  Arg Thr Leu Lys Gln  Cys Gln Thr Leu Arg  Glu Ala Leu 
    1325                 1330                 1335             


Ile Ala  Ala Gly Lys Glu Ile  Ile Trp His Gly Arg  Thr Lys Glu 
    1340                 1345                 1350             


Glu Pro  Ala His Tyr Cys Ser  Ile Cys Glu Val Glu  Val Phe Asp 
    1355                 1360                 1365             


Leu Leu  Phe Val Thr Asn Glu  Ser Asn Ser Arg Lys  Thr Tyr Ile 
    1370                 1375                 1380             


Val His  Cys Gln Asp Cys Ala  Arg Lys Thr Ser Gly  Asn Leu Glu 
    1385                 1390                 1395             


Asn Phe  Val Val Leu Glu Gln  Tyr Lys Met Glu Asp  Leu Met Gln 
    1400                 1405                 1410             


Val Tyr  Asp Gln Phe Thr Leu  Ala Pro Pro Leu Pro  Ser Ala Ser 
    1415                 1420                 1425             


Ser 
    


<210>  7422
<211>  1401
<212>  PRT
<213>  Homo Sapiens

<400>  7422

Met Lys Ser Cys Gly Val Ser Leu Ala Thr Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Phe Gly Asp Glu Glu Lys Lys Met Ala Ala Gly Lys Ala Ser Gly 
            20                  25                  30          


Glu Ser Glu Glu Ala Ser Pro Ser Leu Thr Ala Glu Glu Arg Glu Ala 
        35                  40                  45              


Leu Gly Gly Leu Asp Ser Arg Leu Phe Gly Phe Val Arg Phe His Glu 
    50                  55                  60                  


Asp Gly Ala Arg Thr Lys Ala Leu Leu Gly Lys Ala Val Arg Cys Tyr 
65                  70                  75                  80  


Glu Ser Leu Ile Leu Lys Ala Glu Gly Lys Val Glu Ser Asp Phe Phe 
                85                  90                  95      


Cys Gln Leu Gly His Phe Asn Leu Leu Leu Glu Asp Tyr Pro Lys Ala 
            100                 105                 110         


Leu Ser Ala Tyr Gln Arg Tyr Tyr Ser Leu Gln Ser Asp Tyr Trp Lys 
        115                 120                 125             


Asn Ala Ala Phe Leu Tyr Gly Leu Gly Leu Val Tyr Phe His Tyr Asn 
    130                 135                 140                 


Ala Phe Gln Trp Ala Ile Lys Ala Phe Gln Glu Val Leu Tyr Val Asp 
145                 150                 155                 160 


Pro Ser Phe Cys Arg Ala Lys Glu Ile His Leu Arg Leu Gly Leu Met 
                165                 170                 175     


Phe Lys Val Asn Thr Asp Tyr Glu Ser Ser Leu Lys His Phe Gln Leu 
            180                 185                 190         


Ala Leu Val Asp Cys Asn Pro Cys Thr Leu Ser Asn Ala Glu Ile Gln 
        195                 200                 205             


Phe His Ile Ala His Leu Tyr Glu Thr Gln Arg Lys Tyr His Ser Ala 
    210                 215                 220                 


Lys Glu Ala Tyr Glu Gln Leu Leu Gln Thr Glu Asn Leu Ser Ala Gln 
225                 230                 235                 240 


Val Lys Ala Thr Val Leu Gln Gln Leu Gly Trp Met His His Thr Val 
                245                 250                 255     


Asp Leu Leu Gly Asp Lys Ala Thr Lys Glu Ser Tyr Ala Ile Gln Tyr 
            260                 265                 270         


Leu Gln Lys Ser Leu Glu Ala Asp Pro Asn Ser Gly Gln Ser Trp Tyr 
        275                 280                 285             


Phe Leu Gly Arg Cys Tyr Ser Ser Ile Gly Lys Val Gln Asp Ala Phe 
    290                 295                 300                 


Ile Ser Tyr Arg Gln Ser Ile Asp Lys Ser Glu Ala Ser Ala Asp Thr 
305                 310                 315                 320 


Trp Cys Ser Ile Gly Val Leu Tyr Gln Gln Gln Asn Gln Pro Met Asp 
                325                 330                 335     


Ala Leu Gln Ala Tyr Ile Cys Ala Val Gln Leu Asp His Gly His Ala 
            340                 345                 350         


Ala Ala Trp Met Asp Leu Gly Thr Leu Tyr Glu Ser Cys Asn Gln Pro 
        355                 360                 365             


Gln Asp Ala Ile Lys Cys Tyr Leu Asn Ala Thr Arg Ser Lys Ser Cys 
    370                 375                 380                 


Ser Asn Thr Ser Ala Leu Ala Ala Arg Ile Lys Tyr Leu Gln Ala Gln 
385                 390                 395                 400 


Leu Cys Asn Leu Pro Gln Gly Ser Leu Gln Asn Lys Thr Lys Leu Leu 
                405                 410                 415     


Pro Ser Ile Glu Glu Ala Trp Ser Leu Pro Ile Pro Ala Glu Leu Thr 
            420                 425                 430         


Ser Arg Gln Gly Ala Met Asn Thr Ala Gln Gln Asn Thr Ser Asp Asn 
        435                 440                 445             


Trp Ser Gly Gly His Ala Val Ser His Pro Pro Val Gln Gln Gln Ala 
    450                 455                 460                 


His Ser Trp Cys Leu Thr Pro Gln Lys Leu Gln His Leu Glu Gln Leu 
465                 470                 475                 480 


Arg Ala Asn Arg Asn Asn Leu Asn Pro Ala Gln Lys Leu Met Leu Glu 
                485                 490                 495     


Gln Leu Glu Ser Gln Phe Val Leu Met Gln Gln His Gln Met Arg Pro 
            500                 505                 510         


Thr Gly Val Ala Gln Val Arg Ser Thr Gly Ile Pro Asn Gly Pro Thr 
        515                 520                 525             


Ala Asp Ser Ser Leu Pro Thr Asn Ser Val Ser Gly Gln Gln Pro Gln 
    530                 535                 540                 


Leu Ala Leu Thr Arg Val Pro Ser Val Ser Gln Pro Gly Val Arg Pro 
545                 550                 555                 560 


Ala Cys Pro Gly Gln Pro Leu Ala Asn Gly Pro Phe Ser Ala Gly His 
                565                 570                 575     


Val Pro Cys Ser Thr Ser Arg Thr Leu Gly Ser Thr Asp Thr Ile Leu 
            580                 585                 590         


Ile Gly Asn Asn His Ile Thr Gly Ser Gly Ser Asn Gly Asn Val Pro 
        595                 600                 605             


Tyr Leu Gln Arg Asn Ala Leu Thr Leu Pro His Asn Arg Thr Asn Leu 
    610                 615                 620                 


Thr Ser Ser Ala Glu Glu Pro Trp Lys Asn Gln Leu Ser Asn Ser Thr 
625                 630                 635                 640 


Gln Gly Leu His Lys Gly Gln Ser Ser His Ser Ala Gly Pro Asn Gly 
                645                 650                 655     


Glu Arg Pro Leu Ser Ser Thr Gly Pro Ser Gln His Leu Gln Ala Ala 
            660                 665                 670         


Gly Ser Gly Ile Gln Asn Gln Asn Gly His Pro Thr Leu Pro Ser Asn 
        675                 680                 685             


Ser Val Thr Gln Gly Ala Ala Leu Asn His Leu Ser Ser His Thr Ala 
    690                 695                 700                 


Thr Ser Gly Gly Gln Gln Gly Ile Thr Leu Thr Lys Glu Ser Lys Pro 
705                 710                 715                 720 


Ser Gly Asn Ile Leu Thr Val Pro Glu Thr Ser Arg His Thr Gly Glu 
                725                 730                 735     


Thr Pro Asn Ser Thr Ala Ser Val Glu Gly Leu Pro Asn His Val His 
            740                 745                 750         


Gln Met Thr Ala Asp Ala Val Cys Ser Pro Ser His Gly Asp Ser Lys 
        755                 760                 765             


Ser Pro Gly Leu Leu Ser Ser Asp Asn Pro Gln Leu Ser Ala Leu Leu 
    770                 775                 780                 


Met Gly Lys Ala Asn Asn Asn Val Gly Thr Gly Thr Cys Asp Lys Val 
785                 790                 795                 800 


Asn Asn Ile His Pro Ala Val His Thr Lys Thr Asp Asn Ser Val Ala 
                805                 810                 815     


Ser Ser Pro Ser Ser Ala Ile Ser Thr Ala Thr Pro Ser Pro Lys Ser 
            820                 825                 830         


Thr Glu Gln Thr Thr Thr Asn Ser Val Thr Ser Leu Asn Ser Pro His 
        835                 840                 845             


Ser Gly Leu His Thr Ile Asn Gly Glu Gly Met Glu Glu Ser Gln Ser 
    850                 855                 860                 


Pro Met Lys Thr Asp Leu Leu Leu Val Asn His Lys Pro Ser Pro Gln 
865                 870                 875                 880 


Ile Ile Pro Ser Met Ser Val Ser Ile Tyr Pro Ser Ser Ala Glu Val 
                885                 890                 895     


Leu Lys Ala Cys Arg Asn Leu Gly Lys Asn Gly Leu Ser Asn Ser Ser 
            900                 905                 910         


Ile Leu Leu Asp Lys Cys Pro Pro Pro Arg Pro Pro Ser Ser Pro Tyr 
        915                 920                 925             


Pro Pro Leu Pro Lys Asp Lys Leu Asn Pro Pro Thr Pro Ser Ile Tyr 
    930                 935                 940                 


Leu Glu Asn Lys Arg Asp Ala Phe Phe Pro Pro Leu His Gln Phe Cys 
945                 950                 955                 960 


Thr Asn Pro Asn Asn Pro Val Thr Val Ile Arg Gly Leu Ala Gly Ala 
                965                 970                 975     


Leu Lys Leu Asp Leu Gly Leu Phe Ser Thr Lys Thr Leu Val Glu Ala 
            980                 985                 990         


Asn Asn Glu His Met Val Glu Val  Arg Thr Gln Leu Leu  Gln Pro Ala 
        995                 1000                 1005             


Asp Glu  Asn Trp Asp Pro Thr  Gly Thr Lys Lys Ile  Trp His Cys 
    1010                 1015                 1020             


Glu Ser  Asn Arg Ser His Thr  Thr Ile Ala Lys Tyr  Ala Gln Tyr 
    1025                 1030                 1035             


Gln Ala  Ser Ser Phe Gln Glu  Ser Leu Arg Glu Glu  Asn Glu Lys 
    1040                 1045                 1050             


Arg Ser  His His Lys Asp His  Ser Asp Ser Glu Ser  Thr Ser Ser 
    1055                 1060                 1065             


Asp Asn  Ser Gly Arg Arg Arg  Lys Gly Pro Phe Lys  Thr Ile Lys 
    1070                 1075                 1080             


Phe Gly  Thr Asn Ile Asp Leu  Ser Asp Asp Lys Lys  Trp Lys Leu 
    1085                 1090                 1095             


Gln Leu  His Glu Leu Thr Lys  Leu Pro Ala Phe Val  Arg Val Val 
    1100                 1105                 1110             


Ser Ala  Gly Asn Leu Leu Ser  His Val Gly His Thr  Ile Leu Gly 
    1115                 1120                 1125             


Met Asn  Thr Val Gln Leu Tyr  Met Lys Val Pro Gly  Ser Arg Thr 
    1130                 1135                 1140             


Pro Gly  His Gln Glu Asn Asn  Asn Phe Cys Ser Val  Asn Ile Asn 
    1145                 1150                 1155             


Ile Gly  Pro Gly Asp Cys Glu  Trp Phe Val Val Pro  Glu Gly Tyr 
    1160                 1165                 1170             


Trp Gly  Val Leu Asn Asp Phe  Cys Glu Lys Asn Asn  Leu Asn Phe 
    1175                 1180                 1185             


Leu Met  Gly Ser Trp Trp Pro  Asn Leu Glu Asp Leu  Tyr Glu Ala 
    1190                 1195                 1200             


Asn Val  Pro Val Tyr Arg Phe  Ile Gln Arg Pro Gly  Asp Leu Val 
    1205                 1210                 1215             


Trp Ile  Asn Ala Gly Thr Val  His Trp Val Gln Ala  Ile Gly Trp 
    1220                 1225                 1230             


Cys Asn  Asn Ile Ala Trp Asn  Val Gly Pro Leu Thr  Ala Cys Gln 
    1235                 1240                 1245             


Tyr Lys  Leu Ala Val Glu Arg  Tyr Glu Trp Asn Lys  Leu Gln Ser 
    1250                 1255                 1260             


Val Lys  Ser Ile Val Pro Met  Val His Leu Ser Trp  Asn Met Ala 
    1265                 1270                 1275             


Arg Asn  Ile Lys Val Ser Asp  Pro Lys Leu Phe Glu  Met Ile Lys 
    1280                 1285                 1290             


Tyr Cys  Leu Leu Arg Thr Leu  Lys Gln Cys Gln Thr  Leu Arg Glu 
    1295                 1300                 1305             


Ala Leu  Ile Ala Ala Gly Lys  Glu Ile Ile Trp His  Gly Arg Thr 
    1310                 1315                 1320             


Lys Glu  Glu Pro Ala His Tyr  Cys Ser Ile Cys Glu  Val Glu Val 
    1325                 1330                 1335             


Phe Asp  Leu Leu Phe Val Thr  Asn Glu Ser Asn Ser  Arg Lys Thr 
    1340                 1345                 1350             


Tyr Ile  Val His Cys Gln Asp  Cys Ala Arg Lys Thr  Ser Gly Asn 
    1355                 1360                 1365             


Leu Glu  Asn Phe Val Val Leu  Glu Gln Tyr Lys Met  Glu Asp Leu 
    1370                 1375                 1380             


Met Gln  Val Tyr Asp Gln Phe  Thr Leu Ala Pro Pro  Leu Pro Ser 
    1385                 1390                 1395             


Ala Ser  Ser 
    1400     


<210>  7423
<211>  224
<212>  PRT
<213>  Homo Sapiens

<400>  7423

Met Lys Ser Cys Gly Val Ser Leu Ala Thr Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Phe Gly Asp Glu Glu Lys Lys Met Ala Ala Gly Lys Ala Ser Gly 
            20                  25                  30          


Glu Ser Glu Glu Ala Ser Pro Ser Leu Thr Ala Glu Glu Arg Glu Ala 
        35                  40                  45              


Leu Gly Gly Leu Asp Ser Arg Leu Phe Gly Phe Val Arg Phe His Glu 
    50                  55                  60                  


Asp Gly Ala Arg Thr Lys Ala Leu Leu Gly Lys Ala Val Arg Cys Tyr 
65                  70                  75                  80  


Glu Ser Leu Ile Leu Lys Ala Glu Gly Lys Val Glu Ser Asp Phe Phe 
                85                  90                  95      


Cys Gln Leu Gly His Phe Asn Leu Leu Leu Glu Asp Tyr Pro Lys Ala 
            100                 105                 110         


Leu Ser Ala Tyr Gln Arg Tyr Tyr Ser Leu Gln Ser Asp Tyr Trp Lys 
        115                 120                 125             


Asn Ala Ala Phe Leu Tyr Gly Leu Gly Leu Val Tyr Phe His Tyr Asn 
    130                 135                 140                 


Ala Phe Gln Trp Ala Ile Lys Ala Phe Gln Glu Val Leu Tyr Val Asp 
145                 150                 155                 160 


Pro Ser Phe Cys Arg Ala Lys Glu Ile His Leu Arg Leu Gly Leu Met 
                165                 170                 175     


Phe Lys Val Asn Thr Asp Tyr Glu Ser Ser Leu Lys His Phe Gln Leu 
            180                 185                 190         


Ala Leu Val Asp Cys Asn Pro Cys Thr Leu Ser Asn Ala Glu Ile Gln 
        195                 200                 205             


Phe His Ile Ala His Leu Tyr Glu Thr Gln Val Gly Cys Ile Thr Leu 
    210                 215                 220                 


<210>  7424
<211>  161
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7424

Xaa Ala Arg Asn Ile Lys Val Ser Asp Pro Lys Leu Phe Glu Met Ile 
1               5                   10                  15      


Lys Ile Phe Ser Leu Ser Pro Asn Phe Arg Ala Glu Lys Cys Leu Arg 
            20                  25                  30          


Asp His Leu Val Gln Pro Leu Arg Ser Asn Gly Glu Pro Glu Pro Leu 
        35                  40                  45              


Arg Phe Thr Gly Glu Tyr Cys Leu Leu Arg Thr Leu Lys Gln Cys Gln 
    50                  55                  60                  


Thr Leu Arg Glu Ala Leu Ile Ala Ala Gly Lys Glu Ile Ile Trp His 
65                  70                  75                  80  


Gly Arg Thr Lys Glu Glu Pro Ala His Tyr Cys Ser Ile Cys Glu Val 
                85                  90                  95      


Glu Val Phe Asp Leu Leu Phe Val Thr Asn Glu Ser Asn Ser Arg Lys 
            100                 105                 110         


Thr Tyr Ile Val His Cys Gln Asp Cys Ala Arg Lys Thr Ser Gly Asn 
        115                 120                 125             


Leu Glu Asn Phe Val Val Leu Glu Gln Tyr Lys Met Glu Asp Leu Met 
    130                 135                 140                 


Gln Val Tyr Asp Gln Phe Thr Leu Ala Pro Pro Leu Pro Ser Ala Ser 
145                 150                 155                 160 


Ser 
    


<210>  7425
<211>  999
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7425

Xaa Gly Thr Leu Tyr Glu Ser Cys Asn Gln Pro Gln Asp Ala Ile Lys 
1               5                   10                  15      


Cys Tyr Leu Asn Ala Thr Arg Ser Lys Ser Cys Ser Asn Thr Ser Ala 
            20                  25                  30          


Leu Ala Ala Arg Ile Lys Tyr Leu Gln Asn Thr Ser Asp Asn Trp Ser 
        35                  40                  45              


Gly Gly His Ala Val Ser His Pro Pro Val Gln Gln Gln Ala His Ser 
    50                  55                  60                  


Trp Cys Leu Thr Pro Gln Lys Leu Gln His Leu Glu Gln Leu Arg Ala 
65                  70                  75                  80  


Asn Arg Asn Asn Leu Asn Pro Ala Gln Lys Leu Met Leu Glu Gln Leu 
                85                  90                  95      


Glu Ser Gln Phe Val Leu Met Gln Gln His Gln Met Arg Pro Thr Gly 
            100                 105                 110         


Val Ala Gln Val Arg Ser Thr Gly Ile Pro Asn Gly Pro Thr Ala Asp 
        115                 120                 125             


Ser Ser Leu Pro Thr Asn Ser Val Ser Gly Gln Gln Pro Gln Leu Ala 
    130                 135                 140                 


Leu Thr Arg Val Pro Ser Val Ser Gln Pro Gly Val Arg Pro Ala Cys 
145                 150                 155                 160 


Pro Gly Gln Pro Leu Ala Asn Gly Pro Phe Ser Ala Gly His Val Pro 
                165                 170                 175     


Cys Ser Thr Ser Arg Thr Leu Gly Ser Thr Asp Thr Ile Leu Ile Gly 
            180                 185                 190         


Asn Asn His Ile Thr Gly Ser Gly Ser Asn Gly Asn Val Pro Tyr Leu 
        195                 200                 205             


Gln Arg Asn Ala Leu Thr Leu Pro His Asn Arg Thr Asn Leu Thr Ser 
    210                 215                 220                 


Ser Ala Glu Glu Pro Trp Lys Asn Gln Leu Ser Asn Ser Thr Gln Gly 
225                 230                 235                 240 


Leu His Lys Gly Gln Ser Ser His Ser Ala Gly Pro Asn Gly Glu Arg 
                245                 250                 255     


Pro Leu Ser Ser Thr Gly Pro Ser Gln His Leu Gln Ala Ala Gly Ser 
            260                 265                 270         


Gly Ile Gln Asn Gln Asn Gly His Pro Thr Leu Pro Ser Asn Ser Val 
        275                 280                 285             


Thr Gln Gly Ala Ala Leu Asn His Leu Ser Ser His Thr Ala Thr Ser 
    290                 295                 300                 


Gly Gly Gln Gln Gly Ile Thr Leu Thr Lys Glu Ser Lys Pro Ser Gly 
305                 310                 315                 320 


Asn Ile Leu Thr Val Pro Glu Thr Ser Arg His Thr Gly Glu Thr Pro 
                325                 330                 335     


Asn Ser Thr Ala Ser Val Glu Gly Leu Pro Asn His Val His Gln Met 
            340                 345                 350         


Thr Ala Asp Ala Val Cys Ser Pro Ser His Gly Asp Ser Lys Ser Pro 
        355                 360                 365             


Gly Leu Leu Ser Ser Asp Asn Pro Gln Leu Ser Ala Leu Leu Met Gly 
    370                 375                 380                 


Lys Ala Asn Asn Asn Val Gly Thr Gly Thr Cys Asp Lys Val Asn Asn 
385                 390                 395                 400 


Ile His Pro Ala Val His Thr Lys Thr Asp Asn Ser Val Ala Ser Ser 
                405                 410                 415     


Pro Ser Ser Ala Ile Ser Thr Ala Thr Pro Ser Pro Lys Ser Thr Glu 
            420                 425                 430         


Gln Thr Thr Thr Asn Ser Val Thr Ser Leu Asn Ser Pro His Ser Gly 
        435                 440                 445             


Leu His Thr Ile Asn Gly Glu Gly Met Glu Glu Ser Gln Ser Pro Met 
    450                 455                 460                 


Lys Thr Asp Leu Leu Leu Val Asn His Lys Pro Ser Pro Gln Ile Ile 
465                 470                 475                 480 


Pro Ser Met Ser Val Ser Ile Tyr Pro Ser Ser Ala Glu Val Leu Lys 
                485                 490                 495     


Ala Cys Arg Asn Leu Gly Lys Asn Gly Leu Ser Asn Ser Ser Ile Leu 
            500                 505                 510         


Leu Asp Lys Cys Pro Pro Pro Arg Pro Pro Ser Ser Pro Tyr Pro Pro 
        515                 520                 525             


Leu Pro Lys Asp Lys Leu Asn Pro Pro Thr Pro Ser Ile Tyr Leu Glu 
    530                 535                 540                 


Asn Lys Arg Asp Ala Phe Phe Pro Pro Leu His Gln Phe Cys Thr Asn 
545                 550                 555                 560 


Pro Asn Asn Pro Val Thr Val Ile Arg Gly Leu Ala Gly Ala Leu Lys 
                565                 570                 575     


Leu Asp Leu Gly Leu Phe Ser Thr Lys Thr Leu Val Glu Ala Asn Asn 
            580                 585                 590         


Glu His Met Val Glu Val Arg Thr Gln Leu Leu Gln Pro Ala Asp Glu 
        595                 600                 605             


Asn Trp Asp Pro Thr Gly Thr Lys Lys Ile Trp His Cys Glu Ser Asn 
    610                 615                 620                 


Arg Ser His Thr Thr Ile Ala Lys Tyr Ala Gln Tyr Gln Ala Ser Ser 
625                 630                 635                 640 


Phe Gln Glu Ser Leu Arg Glu Glu Asn Glu Lys Arg Ser His His Lys 
                645                 650                 655     


Asp His Ser Asp Ser Glu Ser Thr Ser Ser Asp Asn Ser Gly Arg Arg 
            660                 665                 670         


Arg Lys Gly Pro Phe Lys Thr Ile Lys Phe Gly Thr Asn Ile Asp Leu 
        675                 680                 685             


Ser Asp Asp Lys Lys Trp Lys Leu Gln Leu His Glu Leu Thr Lys Leu 
    690                 695                 700                 


Pro Ala Phe Val Arg Val Val Ser Ala Gly Asn Leu Leu Ser His Val 
705                 710                 715                 720 


Gly His Thr Ile Leu Gly Met Asn Thr Val Gln Leu Tyr Met Lys Val 
                725                 730                 735     


Pro Gly Ser Arg Thr Pro Gly His Gln Glu Asn Asn Asn Phe Cys Ser 
            740                 745                 750         


Val Asn Ile Asn Ile Gly Pro Gly Asp Cys Glu Trp Phe Val Val Pro 
        755                 760                 765             


Glu Gly Tyr Trp Gly Val Leu Asn Asp Phe Cys Glu Lys Asn Asn Leu 
    770                 775                 780                 


Asn Phe Leu Met Gly Ser Trp Trp Pro Asn Leu Glu Asp Leu Tyr Glu 
785                 790                 795                 800 


Ala Asn Val Pro Val Tyr Arg Phe Ile Gln Arg Pro Gly Asp Leu Val 
                805                 810                 815     


Trp Ile Asn Ala Gly Thr Val His Trp Val Gln Ala Ile Gly Trp Cys 
            820                 825                 830         


Asn Asn Ile Ala Trp Asn Val Gly Pro Leu Thr Ala Cys Gln Tyr Lys 
        835                 840                 845             


Leu Ala Val Glu Arg Tyr Glu Trp Asn Lys Leu Gln Ser Val Lys Ser 
    850                 855                 860                 


Ile Val Pro Met Val His Leu Ser Trp Asn Met Ala Arg Asn Ile Lys 
865                 870                 875                 880 


Val Ser Asp Pro Lys Leu Phe Glu Met Ile Lys Tyr Cys Leu Leu Arg 
                885                 890                 895     


Thr Leu Lys Gln Cys Gln Thr Leu Arg Glu Ala Leu Ile Ala Ala Gly 
            900                 905                 910         


Lys Glu Ile Ile Trp His Gly Arg Thr Lys Glu Glu Pro Ala His Tyr 
        915                 920                 925             


Cys Ser Ile Cys Glu Val Glu Val Phe Asp Leu Leu Phe Val Thr Asn 
    930                 935                 940                 


Glu Ser Asn Ser Arg Lys Thr Tyr Ile Val His Cys Gln Asp Cys Ala 
945                 950                 955                 960 


Arg Lys Thr Ser Gly Asn Leu Glu Asn Phe Val Val Leu Glu Gln Tyr 
                965                 970                 975     


Lys Met Glu Asp Leu Met Gln Val Tyr Asp Gln Phe Thr Leu Ala Pro 
            980                 985                 990         


Pro Leu Pro Ser Ala Ser Ser 
        995                 


<210>  7426
<211>  224
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7426

Xaa Leu Gln Ala Tyr Ile Cys Ala Val Gln Leu Asp His Gly His Ala 
1               5                   10                  15      


Ala Ala Trp Met Asp Leu Gly Thr Leu Tyr Glu Ser Cys Asn Gln Pro 
            20                  25                  30          


Gln Asp Ala Ile Lys Cys Tyr Leu Asn Ala Thr Arg Ser Lys Ser Cys 
        35                  40                  45              


Ser Asn Thr Ser Ala Leu Ala Ala Arg Ile Lys Tyr Leu Gln Ala Gln 
    50                  55                  60                  


Leu Cys Asn Leu Pro Gln Gly Ser Leu Gln Asn Lys Thr Lys Leu Leu 
65                  70                  75                  80  


Pro Ser Ile Glu Glu Ala Trp Ser Leu Pro Ile Pro Ala Glu Leu Thr 
                85                  90                  95      


Ser Arg Gln Gly Ala Met Asn Thr Ala Gln Gln Asn Thr Ser Asp Asn 
            100                 105                 110         


Trp Ser Gly Gly His Ala Val Ser His Pro Pro Val Gln Gln Gln Ala 
        115                 120                 125             


His Ser Trp Cys Leu Thr Pro Gln Lys Leu Gln Met Arg Pro Thr Gly 
    130                 135                 140                 


Val Ala Gln Val Arg Ser Thr Gly Ile Pro Asn Gly Pro Thr Ala Asp 
145                 150                 155                 160 


Ser Ser Leu Pro Thr Asn Ser Val Ser Gly Gln Gln Pro Gln Leu Ala 
                165                 170                 175     


Leu Thr Arg Val Pro Ser Val Ser Gln Pro Gly Val Arg Pro Ala Cys 
            180                 185                 190         


Pro Gly Gln Pro Leu Ala Asn Gly Pro Phe Ser Ala Gly His Val Pro 
        195                 200                 205             


Cys Ser Thr Ser Arg Thr Leu Gly Ser Thr Asp Thr Ile Leu Ile Gly 
    210                 215                 220                 


<210>  7427
<211>  1044
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7427

Xaa Asn Lys Thr Lys Leu Leu Pro Ser Ile Glu Glu Ala Trp Ser Leu 
1               5                   10                  15      


Pro Ile Pro Ala Glu Leu Thr Ser Arg Gln Gly Ala Met Asn Thr Ala 
            20                  25                  30          


Gln Gln Ala Cys Lys Pro His His Pro Asn Thr Glu Pro Val Leu Gly 
        35                  40                  45              


Leu Ser Gln Thr Pro Ile Ser Gln Gln Ser Leu Pro Leu His Met Ile 
    50                  55                  60                  


Pro Ser Ser Gln Val Asp Asp Leu Ser Ser Pro Ala Lys Arg Lys Arg 
65                  70                  75                  80  


Thr Ser Ser Pro Thr Lys Asn Thr Ser Asp Asn Trp Ser Gly Gly His 
                85                  90                  95      


Ala Val Ser His Pro Pro Val Gln Gln Gln Ala His Ser Trp Cys Leu 
            100                 105                 110         


Thr Pro Gln Lys Leu Gln His Leu Glu Gln Leu Arg Ala Asn Arg Asn 
        115                 120                 125             


Asn Leu Asn Pro Ala Gln Lys Leu Met Leu Glu Gln Leu Glu Ser Gln 
    130                 135                 140                 


Phe Val Leu Met Gln Gln His Gln Met Arg Pro Thr Gly Val Ala Gln 
145                 150                 155                 160 


Val Arg Ser Thr Gly Ile Pro Asn Gly Pro Thr Ala Asp Ser Ser Leu 
                165                 170                 175     


Pro Thr Asn Ser Val Ser Gly Gln Gln Pro Gln Leu Ala Leu Thr Arg 
            180                 185                 190         


Val Pro Ser Val Ser Gln Pro Gly Val Arg Pro Ala Cys Pro Gly Gln 
        195                 200                 205             


Pro Leu Ala Asn Gly Pro Phe Ser Ala Gly His Val Pro Cys Ser Thr 
    210                 215                 220                 


Ser Arg Thr Leu Gly Ser Thr Asp Thr Ile Leu Ile Gly Asn Asn His 
225                 230                 235                 240 


Ile Thr Gly Ser Gly Ser Asn Gly Asn Val Pro Tyr Leu Gln Arg Asn 
                245                 250                 255     


Ala Leu Thr Leu Pro His Asn Arg Thr Asn Leu Thr Ser Ser Ala Glu 
            260                 265                 270         


Glu Pro Trp Lys Asn Gln Leu Ser Asn Ser Thr Gln Gly Leu His Lys 
        275                 280                 285             


Gly Gln Ser Ser His Ser Ala Gly Pro Asn Gly Glu Arg Pro Leu Ser 
    290                 295                 300                 


Ser Thr Gly Pro Ser Gln His Leu Gln Ala Ala Gly Ser Gly Ile Gln 
305                 310                 315                 320 


Asn Gln Asn Gly His Pro Thr Leu Pro Ser Asn Ser Val Thr Gln Gly 
                325                 330                 335     


Ala Ala Leu Asn His Leu Ser Ser His Thr Ala Thr Ser Gly Gly Gln 
            340                 345                 350         


Gln Gly Ile Thr Leu Thr Lys Glu Ser Lys Pro Ser Gly Asn Ile Leu 
        355                 360                 365             


Thr Val Pro Glu Thr Ser Arg His Thr Gly Glu Thr Pro Asn Ser Thr 
    370                 375                 380                 


Ala Ser Val Glu Gly Leu Pro Asn His Val His Gln Met Thr Ala Asp 
385                 390                 395                 400 


Ala Val Cys Ser Pro Ser His Gly Asp Ser Lys Ser Pro Gly Leu Leu 
                405                 410                 415     


Ser Ser Asp Asn Pro Gln Leu Ser Ala Leu Leu Met Gly Lys Ala Asn 
            420                 425                 430         


Asn Asn Val Gly Thr Gly Thr Cys Asp Lys Val Asn Asn Ile His Pro 
        435                 440                 445             


Ala Val His Thr Lys Thr Asp Asn Ser Val Ala Ser Ser Pro Ser Ser 
    450                 455                 460                 


Ala Ile Ser Thr Ala Thr Pro Ser Pro Lys Ser Thr Glu Gln Thr Thr 
465                 470                 475                 480 


Thr Asn Ser Val Thr Ser Leu Asn Ser Pro His Ser Gly Leu His Thr 
                485                 490                 495     


Ile Asn Gly Glu Gly Met Glu Glu Ser Gln Ser Pro Met Lys Thr Asp 
            500                 505                 510         


Leu Leu Leu Val Asn His Lys Pro Ser Pro Gln Ile Ile Pro Ser Met 
        515                 520                 525             


Ser Val Ser Ile Tyr Pro Ser Ser Ala Glu Val Leu Lys Ala Cys Arg 
    530                 535                 540                 


Asn Leu Gly Lys Asn Gly Leu Ser Asn Ser Ser Ile Leu Leu Asp Lys 
545                 550                 555                 560 


Cys Pro Pro Pro Arg Pro Pro Ser Ser Pro Tyr Pro Pro Leu Pro Lys 
                565                 570                 575     


Asp Lys Leu Asn Pro Pro Thr Pro Ser Ile Tyr Leu Glu Asn Lys Arg 
            580                 585                 590         


Asp Ala Phe Phe Pro Pro Leu His Gln Phe Cys Thr Asn Pro Asn Asn 
        595                 600                 605             


Pro Val Thr Val Ile Arg Gly Leu Ala Gly Ala Leu Lys Leu Asp Leu 
    610                 615                 620                 


Gly Leu Phe Ser Thr Lys Thr Leu Val Glu Ala Asn Asn Glu His Met 
625                 630                 635                 640 


Val Glu Val Arg Thr Gln Leu Leu Gln Pro Ala Asp Glu Asn Trp Asp 
                645                 650                 655     


Pro Thr Gly Thr Lys Lys Ile Trp His Cys Glu Ser Asn Arg Ser His 
            660                 665                 670         


Thr Thr Ile Ala Lys Tyr Ala Gln Tyr Gln Ala Ser Ser Phe Gln Glu 
        675                 680                 685             


Ser Leu Arg Glu Glu Asn Glu Lys Arg Ser His His Lys Asp His Ser 
    690                 695                 700                 


Asp Ser Glu Ser Thr Ser Ser Asp Asn Ser Gly Arg Arg Arg Lys Gly 
705                 710                 715                 720 


Pro Phe Lys Thr Ile Lys Phe Gly Thr Asn Ile Asp Leu Ser Asp Asp 
                725                 730                 735     


Lys Lys Trp Lys Leu Gln Leu His Glu Leu Thr Lys Leu Pro Ala Phe 
            740                 745                 750         


Val Arg Val Val Ser Ala Gly Asn Leu Leu Ser His Val Gly His Thr 
        755                 760                 765             


Ile Leu Gly Met Asn Thr Val Gln Leu Tyr Met Lys Val Pro Gly Ser 
    770                 775                 780                 


Arg Thr Pro Gly His Gln Glu Asn Asn Asn Phe Cys Ser Val Asn Ile 
785                 790                 795                 800 


Asn Ile Gly Pro Gly Asp Cys Glu Trp Phe Val Val Pro Glu Gly Tyr 
                805                 810                 815     


Trp Gly Val Leu Asn Asp Phe Cys Glu Lys Asn Asn Leu Asn Phe Leu 
            820                 825                 830         


Met Gly Ser Trp Trp Pro Asn Leu Glu Asp Leu Tyr Glu Ala Asn Val 
        835                 840                 845             


Pro Val Tyr Arg Phe Ile Gln Arg Pro Gly Asp Leu Val Trp Ile Asn 
    850                 855                 860                 


Ala Gly Thr Val His Trp Val Gln Ala Ile Gly Trp Cys Asn Asn Ile 
865                 870                 875                 880 


Ala Trp Asn Val Gly Pro Leu Thr Ala Cys Gln Tyr Lys Leu Ala Val 
                885                 890                 895     


Glu Arg Tyr Glu Trp Asn Lys Leu Gln Ser Val Lys Ser Ile Val Pro 
            900                 905                 910         


Met Val His Leu Ser Trp Asn Met Ala Arg Asn Ile Lys Val Ser Asp 
        915                 920                 925             


Pro Lys Leu Phe Glu Met Ile Lys Tyr Cys Leu Leu Arg Thr Leu Lys 
    930                 935                 940                 


Gln Cys Gln Thr Leu Arg Glu Ala Leu Ile Ala Ala Gly Lys Glu Ile 
945                 950                 955                 960 


Ile Trp His Gly Arg Thr Lys Glu Glu Pro Ala His Tyr Cys Ser Ile 
                965                 970                 975     


Cys Glu Val Glu Val Phe Asp Leu Leu Phe Val Thr Asn Glu Ser Asn 
            980                 985                 990         


Ser Arg Lys Thr Tyr Ile Val His  Cys Gln Asp Cys Ala  Arg Lys Thr 
        995                 1000                 1005             


Ser Gly  Asn Leu Glu Asn Phe  Val Val Leu Glu Gln  Tyr Lys Met 
    1010                 1015                 1020             


Glu Asp  Leu Met Gln Val Tyr  Asp Gln Phe Thr Leu  Ala Pro Pro 
    1025                 1030                 1035             


Leu Pro  Ser Ala Ser Ser 
    1040                 


<210>  7428
<211>  941
<212>  PRT
<213>  Homo Sapiens

<400>  7428

Met Ala Gly Ala Ala Ala Ala Val Ala Ala Gly Ala Ala Ala Gly Ala 
1               5                   10                  15      


Ala Ala Ala Ala Val Ser Val Ala Ala Pro Gly Arg Ala Ser Ala Pro 
            20                  25                  30          


Pro Pro Pro Pro Pro Val Tyr Cys Val Cys Arg Gln Pro Tyr Asp Val 
        35                  40                  45              


Asn Arg Phe Met Ile Glu Cys Asp Ile Cys Lys Asp Trp Phe His Gly 
    50                  55                  60                  


Ser Cys Val Gly Val Glu Glu His His Ala Val Asp Ile Asp Leu Tyr 
65                  70                  75                  80  


His Cys Pro Asn Cys Ala Val Leu His Gly Ser Ser Leu Met Lys Lys 
                85                  90                  95      


Arg Arg Asn Trp His Arg His Asp Tyr Thr Glu Ile Asp Asp Gly Ser 
            100                 105                 110         


Lys Pro Val Gln Ala Gly Thr Arg Thr Phe Ile Lys Glu Leu Arg Ser 
        115                 120                 125             


Arg Val Phe Pro Ser Ala Asp Glu Ile Ile Ile Lys Met His Gly Ser 
    130                 135                 140                 


Gln Leu Thr Gln Arg Tyr Leu Glu Lys His Gly Phe Asp Val Pro Ile 
145                 150                 155                 160 


Met Val Pro Lys Leu Asp Asp Leu Gly Leu Arg Leu Pro Ser Pro Thr 
                165                 170                 175     


Phe Ser Val Met Asp Val Glu Arg Tyr Val Gly Gly Asp Lys Val Ile 
            180                 185                 190         


Asp Val Ile Asp Val Ala Arg Gln Ala Asp Ser Lys Met Thr Leu His 
        195                 200                 205             


Asn Tyr Val Lys Tyr Phe Met Asn Pro Asn Arg Pro Lys Val Leu Asn 
    210                 215                 220                 


Val Ile Ser Leu Glu Phe Ser Asp Thr Lys Met Ser Glu Leu Val Glu 
225                 230                 235                 240 


Val Pro Asp Ile Ala Lys Lys Leu Ser Trp Val Glu Asn Tyr Trp Pro 
                245                 250                 255     


Asp Asp Ser Val Phe Pro Lys Pro Phe Val Gln Lys Tyr Cys Leu Met 
            260                 265                 270         


Gly Val Gln Asp Ser Tyr Thr Asp Phe His Ile Asp Phe Gly Gly Thr 
        275                 280                 285             


Ser Val Trp Tyr His Val Leu Trp Gly Glu Lys Ile Phe Tyr Leu Ile 
    290                 295                 300                 


Lys Pro Thr Asp Glu Asn Leu Ala Arg Tyr Glu Ser Trp Ser Ser Ser 
305                 310                 315                 320 


Val Thr Gln Ser Glu Val Phe Phe Gly Asp Lys Val Asp Lys Cys Tyr 
                325                 330                 335     


Lys Cys Val Val Lys Gln Gly His Thr Leu Phe Val Pro Thr Gly Trp 
            340                 345                 350         


Ile His Ala Val Leu Thr Ser Gln Asp Cys Met Ala Phe Gly Gly Asn 
        355                 360                 365             


Phe Leu His Asn Leu Asn Ile Gly Met Gln Leu Arg Cys Tyr Glu Met 
    370                 375                 380                 


Glu Lys Arg Leu Lys Thr Pro Asp Leu Phe Lys Phe Pro Phe Phe Glu 
385                 390                 395                 400 


Ala Ile Cys Trp Phe Val Ala Lys Asn Leu Leu Glu Thr Leu Lys Glu 
                405                 410                 415     


Leu Arg Glu Asp Gly Phe Gln Pro Gln Thr Tyr Leu Val Gln Gly Val 
            420                 425                 430         


Lys Ala Leu His Thr Ala Leu Lys Leu Trp Met Lys Lys Glu Leu Val 
        435                 440                 445             


Ser Glu His Ala Phe Glu Ile Pro Asp Asn Val Arg Pro Gly His Leu 
    450                 455                 460                 


Ile Lys Glu Leu Ser Lys Val Ile Arg Ala Ile Glu Glu Glu Asn Gly 
465                 470                 475                 480 


Lys Pro Val Lys Ser Gln Gly Ile Pro Ile Val Cys Pro Val Ser Arg 
                485                 490                 495     


Ser Ser Asn Glu Ala Thr Ser Pro Tyr His Ser Arg Arg Lys Met Arg 
            500                 505                 510         


Lys Leu Arg Asp His Asn Val Arg Thr Pro Ser Asn Leu Asp Ile Leu 
        515                 520                 525             


Glu Leu His Thr Arg Glu Val Leu Lys Arg Leu Glu Met Cys Pro Trp 
    530                 535                 540                 


Glu Glu Asp Ile Leu Ser Ser Lys Leu Asn Gly Lys Phe Asn Lys His 
545                 550                 555                 560 


Leu Gln Pro Ser Ser Thr Val Pro Glu Trp Arg Ala Lys Asp Asn Asp 
                565                 570                 575     


Leu Arg Leu Leu Leu Thr Asn Gly Arg Ile Ile Lys Asp Glu Arg Gln 
            580                 585                 590         


Pro Phe Ala Asp Gln Ser Leu Tyr Thr Ala Asp Ser Glu Asn Glu Glu 
        595                 600                 605             


Asp Lys Arg Arg Thr Lys Lys Ala Lys Met Lys Ile Glu Glu Ser Ser 
    610                 615                 620                 


Gly Val Glu Gly Val Glu His Glu Glu Ser Gln Lys Pro Leu Asn Gly 
625                 630                 635                 640 


Phe Phe Thr Arg Val Lys Ser Glu Leu Arg Ser Arg Ser Ser Gly Tyr 
                645                 650                 655     


Ser Asp Ile Ser Glu Ser Glu Asp Ser Gly Pro Glu Cys Thr Ala Leu 
            660                 665                 670         


Lys Ser Ile Phe Thr Thr Glu Glu Ser Glu Ser Ser Gly Asp Glu Lys 
        675                 680                 685             


Lys Gln Glu Ile Thr Ser Asn Phe Lys Glu Glu Ser Asn Val Met Arg 
    690                 695                 700                 


Asn Phe Leu Gln Lys Ser Gln Lys Pro Ser Arg Ser Glu Ile Pro Ile 
705                 710                 715                 720 


Lys Arg Glu Cys Pro Thr Ser Thr Ser Thr Glu Glu Glu Ala Ile Gln 
                725                 730                 735     


Gly Met Leu Ser Met Ala Gly Leu His Tyr Ser Thr Cys Leu Gln Arg 
            740                 745                 750         


Gln Ile Gln Ser Thr Asp Cys Ser Gly Glu Arg Asn Ser Leu Gln Asp 
        755                 760                 765             


Pro Ser Ser Cys His Gly Ser Asn His Glu Val Arg Gln Leu Tyr Arg 
    770                 775                 780                 


Tyr Asp Lys Pro Val Glu Cys Gly Tyr His Val Lys Thr Glu Asp Pro 
785                 790                 795                 800 


Asp Leu Arg Thr Ser Ser Trp Ile Lys Gln Phe Asp Thr Ser Arg Phe 
                805                 810                 815     


His Pro Gln Asp Leu Ser Arg Ser Gln Lys Cys Ile Arg Lys Glu Gly 
            820                 825                 830         


Ser Ser Glu Ile Ser Gln Arg Val Gln Ser Arg Asn Tyr Val Asp Ser 
        835                 840                 845             


Ser Gly Ser Ser Leu Gln Asn Gly Lys Tyr Met Gln Asn Ser Asn Leu 
    850                 855                 860                 


Thr Ser Gly Ala Cys Gln Ile Ser Asn Gly Ser Leu Ser Pro Glu Arg 
865                 870                 875                 880 


Pro Val Gly Glu Thr Ser Phe Ser Val Pro Leu His Pro Thr Lys Arg 
                885                 890                 895     


Pro Ala Ser Asn Pro Pro Pro Ile Ser Asn Gln Ala Thr Lys Gly Lys 
            900                 905                 910         


Arg Pro Lys Lys Gly Met Ala Thr Ala Lys Gln Arg Leu Gly Lys Ile 
        915                 920                 925             


Leu Lys Leu Asn Arg Asn Gly His Ala Arg Phe Phe Val 
    930                 935                 940     


<210>  7429
<211>  404
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7429

Xaa Ala Lys Asn Leu Leu Glu Thr Leu Lys Glu Leu Arg Glu Asp Gly 
1               5                   10                  15      


Phe Gln Pro Gln Thr Tyr Leu Val Gln Gly Val Lys Ala Leu His Thr 
            20                  25                  30          


Ala Leu Lys Leu Trp Met Lys Lys Glu Leu Val Ser Glu His Ala Phe 
        35                  40                  45              


Glu Ile Pro Asp Asn Val Arg Pro Gly His Leu Ile Lys Glu Leu Ser 
    50                  55                  60                  


Lys Val Ile Arg Ala Ile Glu Glu Glu Asn Gly Lys Pro Val Lys Ser 
65                  70                  75                  80  


Gln Gly Ile Pro Ile Val Cys Pro Val Ser Arg Ser Ser Asn Glu Ala 
                85                  90                  95      


Thr Ser Pro Tyr His Ser Arg Arg Lys Met Arg Lys Leu Arg Asp His 
            100                 105                 110         


Asn Val Arg Thr Pro Ser Asn Leu Asp Ile Leu Glu Leu His Thr Arg 
        115                 120                 125             


Glu Val Leu Lys Arg Leu Glu Met Cys Pro Trp Glu Glu Asp Ile Leu 
    130                 135                 140                 


Ser Ser Lys Leu Asn Gly Lys Phe Asn Lys His Leu Gln Pro Ser Ser 
145                 150                 155                 160 


Thr Val Pro Glu Trp Arg Ala Lys Asp Asn Asp Leu Arg Leu Leu Leu 
                165                 170                 175     


Thr Asn Gly Arg Ile Ile Lys Asp Glu Arg Gln Pro Phe Ala Asp Gln 
            180                 185                 190         


Ser Leu Tyr Thr Ala Asp Ser Glu Asn Glu Glu Asp Lys Arg Arg Thr 
        195                 200                 205             


Lys Lys Ala Lys Met Lys Ile Glu Glu Ser Ser Gly Val Glu Gly Val 
    210                 215                 220                 


Glu His Glu Glu Ser Gln Lys Pro Leu Asn Gly Phe Phe Thr Arg Val 
225                 230                 235                 240 


Lys Ser Glu Leu Arg Ser Arg Ser Ser Gly Tyr Ser Asp Ile Ser Glu 
                245                 250                 255     


Ser Glu Asp Ser Gly Pro Glu Cys Thr Ala Leu Lys Ser Ile Phe Thr 
            260                 265                 270         


Thr Glu Glu Ser Glu Ser Ser Gly Asp Glu Lys Lys Gln Glu Ile Thr 
        275                 280                 285             


Ser Asn Phe Lys Glu Glu Ser Asn Val Met Arg Asn Phe Leu Gln Lys 
    290                 295                 300                 


Ser Gln Lys Pro Ser Arg Ser Glu Ile Pro Ile Lys Arg Glu Cys Pro 
305                 310                 315                 320 


Thr Ser Thr Ser Thr Glu Glu Glu Ala Ile Gln Gly Met Leu Ser Met 
                325                 330                 335     


Ala Gly Leu His Tyr Ser Thr Cys Leu Gln Arg Gln Ile Gln Ser Thr 
            340                 345                 350         


Asp Cys Ser Gly Glu Arg Asn Ser Leu Gln Asp Pro Ser Ser Cys His 
        355                 360                 365             


Gly Ser Asn His Glu Val Arg Gln Leu Tyr Arg Tyr Asp Lys Pro Val 
    370                 375                 380                 


Glu Cys Glu Thr Arg Ser His Leu Cys Cys Pro Asp Trp Ser Pro Thr 
385                 390                 395                 400 


Pro Glu Leu Lys 
                


<210>  7430
<211>  39
<212>  PRT
<213>  Homo Sapiens

<400>  7430

Met Leu Leu Leu Ala Ala Ala Phe Leu Val Ala Phe Val Leu Leu Leu 
1               5                   10                  15      


Tyr Met Val Ser Pro Leu Ile Ser Pro Lys Pro Leu Ala Leu Pro Gly 
            20                  25                  30          


Ala His Val Val Phe Phe Arg 
        35                  


<210>  7431
<211>  155
<212>  PRT
<213>  Homo Sapiens

<400>  7431

Met Leu Leu Leu Ala Ala Ala Phe Leu Val Ala Phe Val Leu Leu Leu 
1               5                   10                  15      


Tyr Met Val Ser Pro Leu Ile Ser Pro Lys Pro Leu Ala Leu Pro Gly 
            20                  25                  30          


Ala His Val Val Val Thr Gly Gly Ser Ser Gly Ile Gly Lys Cys Ile 
        35                  40                  45              


Ala Ile Glu Cys Tyr Lys Gln Gly Ala Phe Ile Thr Leu Val Ala Arg 
    50                  55                  60                  


Asn Glu Asp Lys Leu Leu Gln Ala Lys Lys Glu Ile Glu Met His Ser 
65                  70                  75                  80  


Ile Asn Asp Lys Gln Val Val Leu Cys Ile Ser Val Asp Val Ser Gln 
                85                  90                  95      


Asp Tyr Asn Gln Val Glu Asn Val Ile Lys Gln Ala Gln Glu Lys Leu 
            100                 105                 110         


Gly Pro Val Asp Met Leu Val Asn Cys Ala Gly Met Ala Val Ser Gly 
        115                 120                 125             


Lys Phe Glu Asp Leu Glu Arg Leu Met Ser Ile Asn Tyr Leu Gly Ser 
    130                 135                 140                 


Val Tyr Pro Ser Arg Ala Val Ile Thr Thr Met 
145                 150                 155 


<210>  7432
<211>  332
<212>  PRT
<213>  Homo Sapiens

<400>  7432

Met Leu Leu Leu Ala Ala Ala Phe Leu Val Ala Phe Val Leu Leu Leu 
1               5                   10                  15      


Tyr Met Val Ser Pro Leu Ile Ser Pro Lys Pro Leu Ala Leu Pro Gly 
            20                  25                  30          


Ala His Val Val Val Thr Gly Gly Ser Ser Gly Ile Gly Lys Cys Ile 
        35                  40                  45              


Ala Ile Glu Cys Tyr Lys Gln Gly Ala Phe Ile Thr Leu Val Ala Arg 
    50                  55                  60                  


Asn Glu Asp Lys Leu Leu Gln Ala Lys Lys Glu Ile Glu Met His Ser 
65                  70                  75                  80  


Ile Asn Asp Lys Gln Val Val Leu Cys Ile Ser Val Asp Val Ser Gln 
                85                  90                  95      


Asp Tyr Asn Gln Val Glu Asn Val Ile Lys Gln Ala Gln Glu Lys Leu 
            100                 105                 110         


Gly Pro Val Asp Met Leu Val Asn Cys Ala Gly Met Ala Val Ser Gly 
        115                 120                 125             


Lys Phe Glu Asp Leu Glu Val Ser Thr Phe Glu Arg Leu Met Ser Ile 
    130                 135                 140                 


Asn Tyr Leu Gly Ser Val Tyr Pro Ser Arg Ala Val Ile Thr Thr Met 
145                 150                 155                 160 


Lys Glu Arg Arg Val Gly Arg Ile Val Phe Val Ser Ser Gln Ala Gly 
                165                 170                 175     


Gln Leu Gly Leu Phe Gly Phe Thr Ala Tyr Ser Ala Ser Lys Phe Ala 
            180                 185                 190         


Ile Arg Gly Leu Ala Glu Ala Leu Gln Met Glu Val Lys Pro Tyr Asn 
        195                 200                 205             


Val Tyr Ile Thr Val Ala Tyr Pro Pro Asp Thr Asp Thr Pro Gly Phe 
    210                 215                 220                 


Ala Glu Glu Asn Arg Thr Lys Pro Leu Glu Thr Arg Leu Ile Ser Glu 
225                 230                 235                 240 


Thr Thr Ser Val Cys Lys Pro Glu Gln Val Ala Lys Gln Ile Val Lys 
                245                 250                 255     


Asp Ala Ile Gln Gly Asn Phe Asn Ser Ser Leu Gly Ser Asp Gly Tyr 
            260                 265                 270         


Met Leu Ser Ala Leu Thr Cys Gly Met Ala Pro Val Thr Ser Ile Thr 
        275                 280                 285             


Glu Gly Leu Gln Gln Val Val Thr Met Gly Leu Phe Arg Thr Ile Ala 
    290                 295                 300                 


Leu Phe Tyr Leu Gly Ser Phe Asp Ser Ile Val Arg Arg Cys Met Met 
305                 310                 315                 320 


Gln Arg Glu Lys Ser Glu Asn Ala Asp Lys Thr Ala 
                325                 330         


<210>  7433
<211>  332
<212>  PRT
<213>  Homo Sapiens

<400>  7433

Met Leu Leu Leu Ala Ala Ala Phe Leu Val Ala Phe Val Leu Leu Leu 
1               5                   10                  15      


Tyr Met Val Ser Pro Leu Ile Ser Pro Lys Pro Leu Ala Leu Pro Gly 
            20                  25                  30          


Ala His Val Val Val Thr Gly Gly Ser Ser Gly Ile Gly Lys Cys Ile 
        35                  40                  45              


Ala Ile Glu Cys Tyr Lys Gln Gly Ala Phe Ile Thr Leu Val Ala Arg 
    50                  55                  60                  


Asn Glu Asp Lys Leu Leu Gln Ala Lys Lys Glu Ile Glu Met His Ser 
65                  70                  75                  80  


Ile Asn Asp Lys Gln Val Val Leu Cys Ile Ser Val Asp Val Ser Gln 
                85                  90                  95      


Asp Tyr Asn Gln Val Glu Asn Val Ile Lys Gln Ala Gln Glu Lys Leu 
            100                 105                 110         


Gly Pro Val Asp Met Leu Val Asn Cys Ala Gly Met Ala Val Ser Gly 
        115                 120                 125             


Lys Phe Glu Asp Leu Glu Val Ser Thr Phe Glu Arg Leu Met Ser Ile 
    130                 135                 140                 


Asn Tyr Leu Gly Ser Val Tyr Pro Ser Arg Ala Val Ile Thr Thr Met 
145                 150                 155                 160 


Lys Glu Arg Arg Val Gly Arg Ile Val Phe Val Ser Ser Gln Ala Gly 
                165                 170                 175     


Gln Leu Gly Leu Phe Gly Phe Thr Ala Tyr Ser Ala Ser Lys Phe Ala 
            180                 185                 190         


Ile Arg Gly Leu Ala Glu Ala Leu Gln Met Glu Val Lys Pro Tyr Asn 
        195                 200                 205             


Val Tyr Ile Thr Val Ala Tyr Pro Pro Asp Thr Asp Thr Pro Gly Phe 
    210                 215                 220                 


Ala Glu Glu Asn Arg Thr Lys Pro Leu Glu Thr Arg Leu Ile Ser Glu 
225                 230                 235                 240 


Thr Thr Ser Val Cys Lys Pro Glu Gln Val Ala Lys Gln Ile Val Lys 
                245                 250                 255     


Asp Ala Ile Gln Gly Asn Phe Asn Ser Ser Leu Gly Ser Asp Gly Tyr 
            260                 265                 270         


Met Leu Ser Ala Leu Thr Cys Gly Met Ala Pro Val Thr Ser Ile Thr 
        275                 280                 285             


Glu Gly Leu Gln Gln Val Val Thr Met Gly Leu Phe Arg Thr Ile Ala 
    290                 295                 300                 


Leu Phe Tyr Leu Gly Ser Phe Asp Ser Ile Val Arg Arg Cys Met Met 
305                 310                 315                 320 


Gln Arg Glu Lys Ser Glu Asn Ala Asp Lys Thr Ala 
                325                 330         


<210>  7434
<211>  298
<212>  PRT
<213>  Homo Sapiens

<400>  7434

Met Leu Leu Leu Ala Ala Ala Phe Leu Val Ala Phe Val Leu Leu Leu 
1               5                   10                  15      


Tyr Met Val Ser Pro Leu Ile Ser Pro Lys Pro Leu Ala Leu Pro Gly 
            20                  25                  30          


Ala His Val Val Val Thr Gly Gly Ser Ser Gly Ile Gly Lys Cys Ile 
        35                  40                  45              


Ala Ile Glu Cys Tyr Lys Gln Gly Ala Phe Ile Thr Leu Val Ala Arg 
    50                  55                  60                  


Asn Glu Asp Lys Leu Leu Gln Ala Lys Lys Glu Ile Glu Met His Ser 
65                  70                  75                  80  


Ile Asn Asp Lys Gln Val Val Leu Cys Ile Ser Val Asp Val Ser Gln 
                85                  90                  95      


Asp Tyr Asn Gln Val Glu Asn Val Ile Lys Gln Ala Gln Glu Lys Leu 
            100                 105                 110         


Gly Pro Val Asp Met Leu Val Asn Cys Ala Gly Met Ala Val Ser Gly 
        115                 120                 125             


Lys Phe Glu Asp Leu Glu Val Ser Thr Phe Glu Arg Leu Met Ser Ile 
    130                 135                 140                 


Asn Tyr Leu Gly Ser Val Tyr Pro Ser Arg Ala Val Ile Thr Thr Met 
145                 150                 155                 160 


Lys Glu Arg Arg Val Gly Arg Ile Val Phe Val Ser Ser Gln Ala Gly 
                165                 170                 175     


Gln Leu Gly Leu Phe Gly Phe Thr Ala Tyr Ser Ala Ser Lys Phe Ala 
            180                 185                 190         


Ile Arg Gly Leu Ala Glu Ala Leu Gln Met Glu Val Lys Pro Tyr Asn 
        195                 200                 205             


Val Tyr Ile Thr Val Ala Tyr Pro Pro Asp Thr Asp Thr Pro Gly Phe 
    210                 215                 220                 


Ala Glu Glu Asn Arg Thr Lys Pro Leu Glu Thr Arg Leu Ile Ser Glu 
225                 230                 235                 240 


Thr Thr Ser Val Cys Lys Pro Glu Gln Val Ala Lys Gln Ile Val Lys 
                245                 250                 255     


Asp Ala Ile Val Val Thr Met Gly Leu Phe Arg Thr Ile Ala Leu Phe 
            260                 265                 270         


Tyr Leu Gly Ser Phe Asp Ser Ile Val Arg Arg Cys Met Met Gln Arg 
        275                 280                 285             


Glu Lys Ser Glu Asn Ala Asp Lys Thr Ala 
    290                 295             


<210>  7435
<211>  268
<212>  PRT
<213>  Homo Sapiens

<400>  7435

Met Leu Leu Leu Ala Ala Ala Phe Leu Val Ala Phe Val Leu Leu Leu 
1               5                   10                  15      


Tyr Met Val Ser Pro Leu Ile Ser Pro Lys Pro Leu Ala Leu Pro Gly 
            20                  25                  30          


Ala His Val Val Val Thr Gly Gly Ser Ser Gly Ile Gly Lys Cys Ile 
        35                  40                  45              


Ala Ile Glu Cys Tyr Lys Gln Gly Ala Phe Ile Thr Leu Val Ala Arg 
    50                  55                  60                  


Asn Glu Asp Lys Leu Leu Gln Ala Lys Lys Glu Ile Glu Met His Ser 
65                  70                  75                  80  


Ile Asn Asp Lys Gln Val Val Leu Cys Ile Ser Val Asp Val Ser Gln 
                85                  90                  95      


Asp Tyr Asn Gln Val Glu Asn Val Ile Lys Gln Ala Gln Glu Lys Leu 
            100                 105                 110         


Gly Pro Val Asp Met Leu Val Asn Cys Ala Gly Met Ala Val Ser Gly 
        115                 120                 125             


Lys Phe Glu Asp Leu Glu Val Ser Thr Phe Glu Val Lys Pro Tyr Asn 
    130                 135                 140                 


Val Tyr Ile Thr Val Ala Tyr Pro Pro Asp Thr Asp Thr Pro Gly Phe 
145                 150                 155                 160 


Ala Glu Glu Asn Arg Thr Lys Pro Leu Glu Thr Arg Leu Ile Ser Glu 
                165                 170                 175     


Thr Thr Ser Val Cys Lys Pro Glu Gln Val Ala Lys Gln Ile Val Lys 
            180                 185                 190         


Asp Ala Ile Gln Gly Asn Phe Asn Ser Ser Leu Gly Ser Asp Gly Tyr 
        195                 200                 205             


Met Leu Ser Ala Leu Thr Cys Gly Met Ala Pro Val Thr Ser Ile Thr 
    210                 215                 220                 


Glu Gly Leu Gln Gln Val Val Thr Met Gly Leu Phe Arg Thr Ile Ala 
225                 230                 235                 240 


Leu Phe Tyr Leu Gly Ser Phe Asp Ser Ile Val Arg Arg Cys Met Met 
                245                 250                 255     


Gln Arg Glu Lys Ser Glu Asn Ala Asp Lys Thr Ala 
            260                 265             


<210>  7436
<211>  39
<212>  PRT
<213>  Homo Sapiens

<400>  7436

Met Leu Leu Leu Ala Ala Ala Phe Leu Val Ala Phe Val Leu Leu Leu 
1               5                   10                  15      


Tyr Met Val Ser Pro Leu Ile Ser Pro Lys Pro Leu Ala Leu Pro Gly 
            20                  25                  30          


Ala His Val Val Trp Glu Gly 
        35                  


<210>  7437
<211>  352
<212>  PRT
<213>  Homo Sapiens

<400>  7437

Met Ala Gly Thr Ile Cys Phe Ile Met Trp Val Leu Phe Ile Thr Asp 
1               5                   10                  15      


Thr Val Trp Ser Arg Ser Val Arg Gln Val Tyr Glu Val His Asp Ser 
            20                  25                  30          


Asp Asp Trp Thr Ile His Asp Phe Glu Cys Pro Met Glu Cys Phe Cys 
        35                  40                  45              


Pro Pro Ser Phe Pro Thr Ala Leu Tyr Cys Glu Asn Arg Gly Leu Lys 
    50                  55                  60                  


Glu Ile Pro Ala Ile Pro Ser Arg Ile Trp Tyr Leu Tyr Leu Gln Asn 
65                  70                  75                  80  


Asn Leu Ile Glu Thr Ile Pro Glu Lys Pro Phe Glu Asn Ala Thr Gln 
                85                  90                  95      


Leu Arg Trp Ile Asn Leu Asn Lys Asn Lys Ile Thr Asn Tyr Gly Ile 
            100                 105                 110         


Glu Lys Gly Ala Leu Ser Gln Leu Lys Lys Leu Leu Phe Leu Phe Leu 
        115                 120                 125             


Glu Asp Asn Glu Leu Glu Glu Val Pro Ser Pro Leu Pro Arg Ser Leu 
    130                 135                 140                 


Glu Gln Leu Gln Leu Ala Arg Asn Lys Val Ser Arg Ile Pro Gln Gly 
145                 150                 155                 160 


Thr Phe Ser Asn Leu Glu Asn Leu Thr Leu Leu Asp Leu Gln Asn Asn 
                165                 170                 175     


Lys Leu Val Asp Asn Ala Phe Gln Arg Asp Thr Phe Lys Gly Leu Lys 
            180                 185                 190         


Asn Leu Met Gln Leu Asn Met Ala Lys Asn Ala Leu Arg Asn Met Pro 
        195                 200                 205             


Pro Arg Leu Pro Ala Asn Thr Met Gln Leu Phe Leu Asp Asn Asn Ser 
    210                 215                 220                 


Ile Glu Gly Ile Pro Glu Asn Tyr Phe Asn Val Ile Pro Lys Val Ala 
225                 230                 235                 240 


Phe Leu Arg Leu Asn His Asn Lys Leu Ser Asp Glu Gly Leu Pro Ser 
                245                 250                 255     


Arg Gly Phe Asp Val Ser Ser Ile Leu Asp Leu Gln Leu Ser His Asn 
            260                 265                 270         


Gln Leu Thr Lys Val Pro Arg Ile Ser Ala His Leu Gln His Leu His 
        275                 280                 285             


Leu Asp His Asn Lys Ile Lys Ser Val Asn Val Ser Val Ile Cys Pro 
    290                 295                 300                 


Ser Pro Ser Met Leu Pro Ala Glu Arg Asp Ser Phe Ser Tyr Gly Pro 
305                 310                 315                 320 


His Leu Arg Tyr Leu Arg Leu Asp Gly Asn Glu Ile Lys Pro Pro Ile 
                325                 330                 335     


Pro Met Ala Leu Met Thr Cys Phe Arg Leu Leu Gln Ala Val Ile Ile 
            340                 345                 350         


<210>  7438
<211>  287
<212>  PRT
<213>  Homo Sapiens

<400>  7438

Asp Pro Ser Pro Pro Leu Pro Trp Trp Asp Lys Ser Arg Leu Leu Phe 
1               5                   10                  15      


His Gly Asp Trp His Met Asp Ile Glu Gln Ala Asn Leu His Gln Leu 
            20                  25                  30          


Ala Thr Glu Phe Val Phe Lys Gly Asp Leu Asp Ile Asn Val Arg Thr 
        35                  40                  45              


Ala Ser Lys Tyr Asp Asp Cys Cys Phe Leu His Leu Pro Asp Leu Cys 
    50                  55                  60                  


Met Thr Leu Asp Leu Gln Trp Leu Cys His Gly Asn Pro His Asp His 
65                  70                  75                  80  


His Ser Val Thr Leu Arg Ala Pro Glu Phe Leu Pro Glu Val Pro Leu 
                85                  90                  95      


Gly Gln Leu His Asp Ser Tyr Arg Ala Phe Arg Ser Glu Asn Leu Asn 
            100                 105                 110         


Leu Ser Ile Lys Met Asp Leu Thr Arg His Ser Gly Thr Ile Ser Gln 
        115                 120                 125             


Pro Arg Ile Leu Leu Tyr Ser Ser Thr Leu Arg Trp Met Gln Asn Phe 
    130                 135                 140                 


Trp Ala Thr Trp Thr Ser Val Thr Arg Pro Ile Cys Arg Gly Lys Leu 
145                 150                 155                 160 


Phe Asn Asn Leu Lys Pro Ser Lys Lys Lys Leu Gly Gln His Tyr Lys 
                165                 170                 175     


Gln Leu Ser Tyr Thr Ala Leu Phe Pro Gln Leu Gln Val His Tyr Trp 
            180                 185                 190         


Ala Ser Phe Ala Gln Gln Arg Gly Ile Gln Ile Glu Cys Ser Gln Gly 
        195                 200                 205             


His Val Phe Thr Arg Gly Thr Gln Arg Leu Ile Pro Gln Ala Gly Thr 
    210                 215                 220                 


Val Met Arg Arg Leu Ile Ser Asp Trp Ser Val Thr Gln Met Val Ser 
225                 230                 235                 240 


Asp Leu Ser Gln Val Thr Val His Leu Met Ala Ser Pro Thr Glu Glu 
                245                 250                 255     


Asn Ala Asp His Cys Leu Asp Pro Leu Val Thr Lys Thr His Leu Leu 
            260                 265                 270         


Ser Leu Ser Ser Leu Thr Tyr Gln Arg His Ser Asn Arg Thr Ala 
        275                 280                 285         


<210>  7439
<211>  2235
<212>  PRT
<213>  Homo Sapiens

<400>  7439

Met Pro Leu Phe Phe Ser Ala Leu Leu Val Leu Leu Leu Val Ala Leu 
1               5                   10                  15      


Ser Ala Leu Phe Leu Gly Arg Trp Leu Val Val Arg Leu Ala Thr Lys 
            20                  25                  30          


Trp Cys Gln Arg Lys Leu Gln Ala Glu Leu Lys Ile Gly Ser Phe Arg 
        35                  40                  45              


Phe Phe Trp Ile Gln Asn Val Ser Leu Lys Phe Gln Gln His Gln Gln 
    50                  55                  60                  


Thr Val Glu Ile Asp Asn Leu Trp Ile Ser Ser Lys Leu Leu Ser His 
65                  70                  75                  80  


Asp Leu Pro His Tyr Val Ala Leu Cys Phe Gly Glu Val Arg Ile Arg 
                85                  90                  95      


Thr Asp Leu Gln Lys Val Ser Asp Leu Ser Ala Pro Phe Ser Gln Ser 
            100                 105                 110         


Ala Gly Val Asp Gln Lys Glu Leu Ser Phe Ser Pro Ser Leu Leu Lys 
        115                 120                 125             


Ile Phe Cys Gln Leu Phe Ser Ile His Val Asp Ala Ile Asn Ile Met 
    130                 135                 140                 


Val Leu Lys Val Asp Thr Ser Glu Ser Leu Trp His Ile Gln Ile Ser 
145                 150                 155                 160 


Arg Ser Arg Phe Leu Leu Asp Ser Asp Gly Lys Arg Leu Ile Cys Glu 
                165                 170                 175     


Val Ser Leu Cys Lys Ile Asn Ser Lys Val Leu Lys Ser Gly Gln Leu 
            180                 185                 190         


Glu Asp Thr Cys Leu Val Glu Leu Ser Leu Ala Leu Asp Leu Cys Leu 
        195                 200                 205             


Lys Val Gly Ile Ser Ser Arg His Leu Thr Ala Ile Thr Val Asp Val 
    210                 215                 220                 


Trp Thr Leu His Ala Glu Leu His Glu Gly Leu Phe Gln Ser Gln Leu 
225                 230                 235                 240 


Leu Cys Gln Gly Pro Ser Leu Ala Ser Lys Pro Val Pro Cys Ser Glu 
                245                 250                 255     


Val Thr Glu Asn Leu Val Glu Pro Thr Leu Pro Gly Leu Phe Leu Leu 
            260                 265                 270         


Gln Gln Leu Pro Asp Gln Val Lys Val Lys Met Glu Asn Thr Ser Val 
        275                 280                 285             


Val Leu Ser Met Asn Ser Gln Lys Arg His Leu Thr Trp Thr Leu Lys 
    290                 295                 300                 


Leu Leu Gln Phe Leu Tyr His Arg Asp Glu Asp Gln Leu Pro Leu Arg 
305                 310                 315                 320 


Ser Phe Thr Ala Asn Ser Asp Met Ala Gln Met Ser Thr Glu Leu Leu 
                325                 330                 335     


Leu Glu Asp Gly Leu Leu Leu Ser Gln Ser Arg Gln Arg Ile Val Cys 
            340                 345                 350         


Leu Asn Ser Leu Lys Ala Ser Val Gln Val Thr Thr Ile Asp Leu Ser 
        355                 360                 365             


Ala Ser Leu Val Leu Asn Thr Cys Ile Ile His Tyr Arg His Gln Glu 
    370                 375                 380                 


Phe Ser His Trp Leu His Leu Leu Ala Leu Glu Thr Gln Gly Ser Ser 
385                 390                 395                 400 


Ser Pro Val Leu Lys Gln Arg Lys Lys Arg Thr Phe Pro Gln Ile Leu 
                405                 410                 415     


Ala Pro Ile Ile Phe Ser Thr Ser Ile Ser Asn Val Asn Ile Ser Ile 
            420                 425                 430         


Gln Leu Gly Asp Thr Pro Pro Phe Ala Leu Gly Phe Asn Ser Ile Ser 
        435                 440                 445             


Leu Asp Tyr Gln His Leu Arg Pro Gln Ser Ile His Gln Arg Gly Val 
    450                 455                 460                 


Leu Thr Val Asp His Leu Cys Trp Arg Val Gly Ser Asp Ser His Ile 
465                 470                 475                 480 


Gln Arg Ala Pro His Pro Pro Asn Met His Val Trp Gly Glu Ala Leu 
                485                 490                 495     


Val Leu Asp Ser Phe Thr Leu Gln Gly Ser Tyr Asn Gln Pro Leu Gly 
            500                 505                 510         


Leu Ser Ser Thr Gln Ser Asp Thr Leu Phe Leu Asp Cys Thr Ile Arg 
        515                 520                 525             


Gly Leu Gln Val Glu Ala Ser Asp Thr Cys Ala Gln Cys Leu Ser Arg 
    530                 535                 540                 


Ile Leu Ser Leu Met Gly Pro Gln Ser Gly Lys Ser Ala Val Ser Arg 
545                 550                 555                 560 


His Ser Ser Phe Gly Glu Ser Val Ser Leu Leu Trp Lys Val Asp Leu 
                565                 570                 575     


Lys Val Glu Asp Met Asn Leu Phe Thr Leu Ser Ala Leu Val Gly Ala 
            580                 585                 590         


Ser Glu Val Arg Leu Asp Thr Leu Thr Ile Leu Gly Ser Ala Glu Thr 
        595                 600                 605             


Ser Thr Val Gly Ile Gln Gly Leu Val Leu Ala Leu Val Lys Ser Val 
    610                 615                 620                 


Thr Glu Lys Met Gln Pro Cys Cys Lys Ala Pro Asp Ile Pro Thr Pro 
625                 630                 635                 640 


Val Leu Ser Leu Ser Met Leu Ser Ile Thr Tyr His Ser Ser Ile Arg 
                645                 650                 655     


Ser Leu Glu Val Gln Cys Gly Ala Gly Leu Thr Leu Leu Trp Ser Pro 
            660                 665                 670         


Pro Asp His Met Tyr Leu Tyr Gln His Val Leu Ala Thr Leu Gln Cys 
        675                 680                 685             


Arg Asp Leu Leu Arg Ala Thr Val Phe Pro Glu Thr Val Pro Ser Leu 
    690                 695                 700                 


Ala Leu Glu Thr Ser Gly Thr Thr Ser Glu Leu Glu Gly Arg Ala Pro 
705                 710                 715                 720 


Glu Pro Leu Pro Pro Lys Arg Leu Leu Asn Leu Thr Leu Glu Val Ser 
                725                 730                 735     


Thr Ala Lys Leu Thr Ala Phe Val Ala Glu Asp Lys Phe Ile Thr Leu 
            740                 745                 750         


Ala Ala Glu Ser Val Ser Leu Ser Arg His Gly Gly Ser Leu Gln Ala 
        755                 760                 765             


Tyr Cys Pro Glu Leu Ala Ala Gly Phe Asp Gly Asn Ser Ile Phe Asn 
    770                 775                 780                 


Phe Lys Glu Val Glu Val Gln Leu Leu Pro Glu Leu Glu Glu Met Ile 
785                 790                 795                 800 


Leu His Arg Asn Pro Phe Pro Ala Leu Gln Thr Leu Arg Asn Arg Val 
                805                 810                 815     


Trp Leu Leu Ser Phe Gly Ser Val Ser Val Glu Phe Pro Tyr Gln Tyr 
            820                 825                 830         


Asp Phe Ser Arg Thr Leu Asp Glu Ala Val Gly Val Gln Lys Trp Leu 
        835                 840                 845             


Lys Gly Leu His Gln Gly Thr Arg Ala Trp Ala Ser Pro Ser Pro Val 
    850                 855                 860                 


Pro Leu Pro Pro Asp Leu Leu Leu Lys Val Glu His Phe Ser Trp Val 
865                 870                 875                 880 


Phe Leu Asp Asp Val Phe Glu Val Lys Leu His Asp Asn Tyr Glu Leu 
                885                 890                 895     


Met Lys Asp Glu Ser Lys Glu Ser Ala Lys Arg Leu Gln Leu Leu Asp 
            900                 905                 910         


Ala Lys Val Ala Ala Leu Arg Lys Gln His Gly Glu Leu Leu Pro Ala 
        915                 920                 925             


Arg Lys Ile Glu Glu Leu Tyr Ala Ser Leu Glu Arg Lys Asn Ile Glu 
    930                 935                 940                 


Ile Tyr Ile Gln Arg Ser Arg Arg Leu Tyr Gly Asn Thr Pro Met Arg 
945                 950                 955                 960 


Arg Ala Leu Leu Thr Trp Ser Leu Ala Gly Leu Glu Leu Val Ala Leu 
                965                 970                 975     


Ala Asp Ala Ser Phe His Gly Pro Glu His Val Val Glu Gln Val Gln 
            980                 985                 990         


Glu Leu Asp Pro Gly Ser Pro Phe  Pro Pro Glu Gly Leu  Asp Leu Val 
        995                 1000                 1005             


Ile Gln  Trp Cys Arg Met Leu  Lys Cys Asn Val Lys  Ser Phe Leu 
    1010                 1015                 1020             


Val Arg  Ile Arg Asp Tyr Pro  Arg Tyr Leu Phe Glu  Ile Arg Asp 
    1025                 1030                 1035             


Trp Arg  Leu Met Gly Arg Leu  Val Gly Thr Glu Gln  Ser Gly Gln 
    1040                 1045                 1050             


Pro Cys  Ser Arg Arg Arg Gln  Ile Leu His Leu Gly  Leu Pro Trp 
    1055                 1060                 1065             


Gly Asn  Val Ala Val Glu Arg  Asn Met Pro Pro Leu  Lys Phe Tyr 
    1070                 1075                 1080             


His Asp  Phe His Ser Glu Ile  Phe Gln Tyr Thr Val  Val Trp Gly 
    1085                 1090                 1095             


Pro Cys  Trp Asp Pro Ala Trp  Thr Leu Ile Gly Gln  Cys Val Asp 
    1100                 1105                 1110             


Leu Leu  Thr Lys Pro Ser Ala  Asp Pro Ser Pro Pro  Leu Pro Trp 
    1115                 1120                 1125             


Trp Asp  Lys Ser Arg Leu Leu  Phe His Gly Asp Trp  His Met Asp 
    1130                 1135                 1140             


Ile Glu  Gln Ala Asn Leu His  Gln Leu Ala Thr Glu  Asp Pro Tyr 
    1145                 1150                 1155             


Asn Thr  Thr Glu Asn Met His  Trp Glu Trp Ser His  Leu Ser Phe 
    1160                 1165                 1170             


His Trp  Lys Pro Gly Gln Phe  Val Phe Lys Gly Asp  Leu Asp Ile 
    1175                 1180                 1185             


Asn Val  Arg Thr Ala Ser Lys  Tyr Asp Asp Cys Cys  Phe Leu His 
    1190                 1195                 1200             


Leu Pro  Asp Leu Cys Met Thr  Leu Asp Leu Gln Trp  Leu Cys His 
    1205                 1210                 1215             


Gly Asn  Pro His Asp His His  Ser Val Thr Leu Arg  Ala Pro Glu 
    1220                 1225                 1230             


Phe Leu  Pro Glu Val Pro Leu  Gly Gln Leu His Asp  Ser Tyr Arg 
    1235                 1240                 1245             


Ala Phe  Arg Ser Glu Asn Leu  Asn Leu Ser Ile Lys  Met Asp Leu 
    1250                 1255                 1260             


Thr Arg  His Ser Gly Thr Ile  Ser Gln Pro Arg Ile  Leu Leu Tyr 
    1265                 1270                 1275             


Ser Ser  Thr Leu Arg Trp Met  Gln Asn Phe Trp Ala  Thr Trp Thr 
    1280                 1285                 1290             


Ser Val  Thr Arg Pro Ile Cys  Arg Gly Lys Leu Phe  Asn Asn Leu 
    1295                 1300                 1305             


Lys Pro  Ser Lys Lys Lys Leu  Gly Gln His Tyr Lys  Gln Leu Ser 
    1310                 1315                 1320             


Tyr Thr  Ala Leu Phe Pro Gln  Leu Gln Val His Tyr  Trp Ala Ser 
    1325                 1330                 1335             


Phe Ala  Gln Gln Arg Gly Ile  Gln Ile Glu Cys Ser  Gln Gly His 
    1340                 1345                 1350             


Val Phe  Thr Arg Gly Thr Gln  Arg Leu Ile Pro Gln  Ala Gly Thr 
    1355                 1360                 1365             


Val Met  Arg Arg Leu Ile Ser  Asp Trp Ser Val Thr  Gln Met Val 
    1370                 1375                 1380             


Ser Asp  Leu Ser Gln Val Thr  Val His Leu Met Ala  Ser Pro Thr 
    1385                 1390                 1395             


Glu Glu  Asn Ala Asp His Cys  Leu Asp Pro Leu Val  Thr Lys Thr 
    1400                 1405                 1410             


His Leu  Leu Ser Leu Ser Ser  Leu Thr Tyr Gln Arg  His Ser Asn 
    1415                 1420                 1425             


Arg Thr  Ala Glu Glu Glu Leu  Ser Ala Arg Asp Gly  Asp Pro Thr 
    1430                 1435                 1440             


Phe His  Thr His Gln Leu His  Leu Val Asp Leu Arg  Ile Ser Trp 
    1445                 1450                 1455             


Thr Thr  Thr Asn Arg Asp Ile  Ala Phe Gly Leu Tyr  Asp Gly Tyr 
    1460                 1465                 1470             


Lys Lys  Ala Ala Val Leu Lys  Arg Asn Leu Ser Thr  Glu Ala Leu 
    1475                 1480                 1485             


Lys Gly  Leu Lys Ile Asp Pro  Gln Met Pro Ala Lys  Lys Pro Lys 
    1490                 1495                 1500             


Arg Gly  Val Pro Thr Ser Ala  Ser Ala Pro Pro Arg  Val Asn Thr 
    1505                 1510                 1515             


Pro Ser  Phe Ser Gly Gln Pro  Asp Lys Gly Ser Ser  Gly Gly Ala 
    1520                 1525                 1530             


Tyr Met  Leu Gln Lys Leu Ile  Glu Glu Thr Asp Arg  Phe Val Val 
    1535                 1540                 1545             


Phe Thr  Glu Glu Glu Ser Gly  Met Ser Asp Gln Leu  Cys Gly Ile 
    1550                 1555                 1560             


Ala Ala  Cys Gln Thr Asp Asp  Ile Tyr Asn Arg Asn  Cys Leu Ile 
    1565                 1570                 1575             


Glu Leu  Val Asn Cys Gln Met  Val Leu Arg Gly Ala  Glu Thr Glu 
    1580                 1585                 1590             


Gly Cys  Val Ile Val Ser Ala  Ala Lys Ala Gln Leu  Leu Gln Cys 
    1595                 1600                 1605             


Gln His  His Pro Ala Trp Tyr  Gly Asp Thr Leu Lys  Gln Lys Thr 
    1610                 1615                 1620             


Ser Trp  Thr Cys Leu Leu Asp  Gly Met Gln Tyr Phe  Ala Thr Thr 
    1625                 1630                 1635             


Glu Ser  Ser Pro Thr Glu Gln  Asp Gly Arg Gln Leu  Trp Leu Glu 
    1640                 1645                 1650             


Val Lys  Asn Ile Glu Glu His  Arg Gln Arg Ser Leu  Asp Ser Val 
    1655                 1660                 1665             


Gln Glu  Leu Met Glu Ser Gly  Gln Ala Val Gly Gly  Met Val Thr 
    1670                 1675                 1680             


Thr Thr  Thr Asp Trp Asn Gln  Pro Ala Glu Ala Gln  Gln Ala Gln 
    1685                 1690                 1695             


Gln Val  Gln Arg Ile Ile Ser  Arg Cys Asn Cys Arg  Met Tyr Tyr 
    1700                 1705                 1710             


Ile Ser  Tyr Ser His Asp Ile  Asp Pro Glu Leu Ala  Thr Gln Ile 
    1715                 1720                 1725             


Lys Pro  Pro Glu Val Leu Glu  Asn Gln Glu Lys Glu  Asp Leu Leu 
    1730                 1735                 1740             


Lys Lys  Gln Glu Gly Ala Val  Asp Thr Phe Thr Leu  Ile His His 
    1745                 1750                 1755             


Glu Leu  Glu Ile Ser Thr Asn  Pro Ala Gln Tyr Ala  Met Ile Leu 
    1760                 1765                 1770             


Asp Ile  Val Asn Asn Leu Leu  Leu His Val Glu Pro  Lys Arg Lys 
    1775                 1780                 1785             


Glu His  Ser Glu Lys Lys Gln  Arg Val Arg Phe Gln  Leu Glu Ile 
    1790                 1795                 1800             


Ser Ser  Asn Pro Glu Glu Gln  Arg Ser Ser Ile Leu  His Leu Gln 
    1805                 1810                 1815             


Glu Ala  Val Arg Gln His Val  Ala Gln Ile Arg Gln  Leu Glu Lys 
    1820                 1825                 1830             


Gln Met  Tyr Ser Ile Met Lys  Ser Leu Gln Asp Asp  Ser Lys Asn 
    1835                 1840                 1845             


Glu Asn  Leu Leu Asp Leu Asn  Gln Lys Leu Gln Leu  Gln Leu Asn 
    1850                 1855                 1860             


Gln Glu  Lys Ala Asn Leu Gln  Leu Glu Ser Glu Glu  Leu Asn Ile 
    1865                 1870                 1875             


Leu Ile  Arg Cys Phe Lys Asp  Phe Gln Leu Gln Arg  Ala Asn Lys 
    1880                 1885                 1890             


Met Glu  Leu Arg Lys Gln Gln  Glu Asp Val Ser Val  Val Arg Arg 
    1895                 1900                 1905             


Thr Glu  Phe Tyr Phe Ala Gln  Ala Arg Trp Arg Leu  Thr Glu Glu 
    1910                 1915                 1920             


Asp Gly  Gln Leu Gly Ile Ala  Glu Leu Glu Leu Gln  Arg Phe Leu 
    1925                 1930                 1935             


Tyr Ser  Lys Val Asn Lys Ser  Asp Asp Thr Ala Glu  His Leu Leu 
    1940                 1945                 1950             


Glu Leu  Gly Trp Phe Thr Met  Asn Asn Leu Leu Pro  Asn Ala Val 
    1955                 1960                 1965             


Tyr Lys  Val Val Leu Arg Pro  Gln Ser Ser Cys Gln  Ser Gly Arg 
    1970                 1975                 1980             


Gln Leu  Ala Leu Arg Leu Phe  Ser Lys Val Arg Pro  Pro Val Gly 
    1985                 1990                 1995             


Gly Ile  Ser Val Lys Glu His  Phe Glu Val Asn Val  Val Pro Leu 
    2000                 2005                 2010             


Thr Ile  Gln Leu Thr His Gln  Phe Phe His Arg Met  Met Gly Phe 
    2015                 2020                 2025             


Phe Phe  Pro Gly Arg Ser Val  Glu Asp Asp Glu Val  Gly Asp Glu 
    2030                 2035                 2040             


Glu Asp  Lys Ser Lys Leu Val  Thr Thr Gly Ile Pro  Val Val Lys 
    2045                 2050                 2055             


Pro Arg  Gln Leu Ile Ala Thr  Asp Asp Ala Val Pro  Leu Gly Pro 
    2060                 2065                 2070             


Gly Lys  Gly Val Ala Gln Gly  Leu Thr Arg Ser Ser  Gly Val Arg 
    2075                 2080                 2085             


Arg Ser  Phe Arg Lys Ser Pro  Glu His Pro Val Asp  Asp Ile Asp 
    2090                 2095                 2100             


Lys Met  Lys Glu Arg Ala Ala  Met Asn Asn Ser Phe  Ile Tyr Ile 
    2105                 2110                 2115             


Lys Ile  Pro Gln Val Pro Leu  Cys Val Ser Tyr Lys  Gly Glu Lys 
    2120                 2125                 2130             


Asn Ser  Val Asp Trp Gly Asp  Leu Asn Leu Val Leu  Pro Cys Leu 
    2135                 2140                 2145             


Glu Tyr  His Asn Asn Thr Trp  Thr Trp Leu Asp Phe  Ala Met Ala 
    2150                 2155                 2160             


Val Lys  Arg Asp Ser Arg Lys  Ala Leu Val Ala Gln  Val Ile Lys 
    2165                 2170                 2175             


Glu Lys  Leu Arg Leu Lys Ser  Ala Thr Gly Ser Glu  Val Arg Gly 
    2180                 2185                 2190             


Lys Leu  Glu Thr Lys Ser Asp  Leu Asn Met Gln Gln  Gln Glu Glu 
    2195                 2200                 2205             


Glu Glu  Lys Ala Arg Leu Leu  Ile Gly Leu Ser Val  Gly Asp Lys 
    2210                 2215                 2220             


Asn Pro  Gly Lys Lys Ser Ile  Phe Gly Arg Arg Lys  
    2225                 2230                 2235 


<210>  7440
<211>  86
<212>  PRT
<213>  Homo Sapiens

<400>  7440

Met Pro Leu Phe Phe Ser Ala Leu Leu Val Leu Leu Leu Val Ala Leu 
1               5                   10                  15      


Ser Ala Leu Phe Leu Gly Arg Trp Leu Val Val Arg Leu Ala Thr Lys 
            20                  25                  30          


Trp Cys Gln Arg Lys Leu Gln Ala Glu Leu Lys Ile Gly Ser Phe Arg 
        35                  40                  45              


Phe Phe Trp Ile Gln Asn Val Ser Leu Lys Phe Gln Gln His Gln Gln 
    50                  55                  60                  


Thr Val Thr Leu Cys Gly Ile Val Leu Trp Arg Ser Ala Tyr Gln Asn 
65                  70                  75                  80  


Gly Pro Thr Glu Ser Phe 
                85      


<210>  7441
<211>  2092
<212>  PRT
<213>  Homo Sapiens

<400>  7441

Met Val Leu Lys Val Asp Thr Ser Glu Ser Leu Trp His Ile Gln Ile 
1               5                   10                  15      


Ser Arg Ser Arg Phe Leu Leu Asp Ser Asp Gly Lys Arg Leu Ile Cys 
            20                  25                  30          


Glu Val Ser Leu Cys Lys Ile Asn Ser Lys Val Leu Lys Ser Gly Gln 
        35                  40                  45              


Leu Glu Asp Thr Cys Leu Val Glu Leu Ser Leu Ala Leu Asp Leu Cys 
    50                  55                  60                  


Leu Lys Val Gly Ile Ser Ser Arg His Leu Thr Ala Ile Thr Val Asp 
65                  70                  75                  80  


Val Trp Thr Leu His Ala Glu Leu His Glu Gly Leu Phe Gln Ser Gln 
                85                  90                  95      


Leu Leu Cys Gln Gly Pro Ser Leu Ala Ser Lys Pro Val Pro Cys Ser 
            100                 105                 110         


Glu Val Thr Glu Asn Leu Val Glu Pro Thr Leu Pro Gly Leu Phe Leu 
        115                 120                 125             


Leu Gln Gln Leu Pro Asp Gln Val Lys Val Lys Met Glu Asn Thr Ser 
    130                 135                 140                 


Val Val Leu Ser Met Asn Ser Gln Lys Arg His Leu Thr Trp Thr Leu 
145                 150                 155                 160 


Lys Leu Leu Gln Phe Leu Tyr His Arg Asp Glu Asp Gln Leu Pro Leu 
                165                 170                 175     


Arg Ser Phe Thr Ala Asn Ser Asp Met Ala Gln Met Ser Thr Glu Leu 
            180                 185                 190         


Leu Leu Glu Asp Gly Leu Leu Leu Ser Gln Ser Arg Gln Arg Ile Val 
        195                 200                 205             


Cys Leu Asn Ser Leu Lys Ala Ser Val Gln Val Thr Thr Ile Asp Leu 
    210                 215                 220                 


Ser Ala Ser Leu Val Leu Asn Thr Cys Ile Ile His Tyr Arg His Gln 
225                 230                 235                 240 


Glu Phe Ser His Trp Leu His Leu Leu Ala Leu Glu Thr Gln Gly Ser 
                245                 250                 255     


Ser Ser Pro Val Leu Lys Gln Arg Lys Lys Arg Thr Phe Pro Gln Ile 
            260                 265                 270         


Leu Ala Pro Ile Ile Phe Ser Thr Ser Ile Ser Asn Val Asn Ile Ser 
        275                 280                 285             


Ile Gln Leu Gly Asp Thr Pro Pro Phe Ala Leu Gly Phe Asn Ser Ile 
    290                 295                 300                 


Ser Leu Asp Tyr Gln His Leu Arg Pro Gln Ser Ile His Gln Arg Gly 
305                 310                 315                 320 


Val Leu Thr Val Asp His Leu Cys Trp Arg Val Gly Ser Asp Ser His 
                325                 330                 335     


Ile Gln Arg Ala Pro His Pro Pro Asn Met His Val Trp Gly Glu Ala 
            340                 345                 350         


Leu Val Leu Asp Ser Phe Thr Leu Gln Gly Ser Tyr Asn Gln Pro Leu 
        355                 360                 365             


Gly Leu Ser Ser Thr Gln Ser Asp Thr Leu Phe Leu Asp Cys Thr Ile 
    370                 375                 380                 


Arg Gly Leu Gln Val Glu Ala Ser Asp Thr Cys Ala Gln Cys Leu Ser 
385                 390                 395                 400 


Arg Ile Leu Ser Leu Met Gly Pro Gln Ser Gly Lys Ser Ala Val Ser 
                405                 410                 415     


Arg His Ser Ser Phe Gly Glu Ser Val Ser Leu Leu Trp Lys Val Asp 
            420                 425                 430         


Leu Lys Val Glu Asp Met Asn Leu Phe Thr Leu Ser Ala Leu Val Gly 
        435                 440                 445             


Ala Ser Glu Val Arg Leu Asp Thr Leu Thr Ile Leu Gly Ser Ala Glu 
    450                 455                 460                 


Thr Ser Thr Val Gly Ile Gln Gly Leu Val Leu Ala Leu Val Lys Ser 
465                 470                 475                 480 


Val Thr Glu Lys Met Gln Pro Cys Cys Lys Ala Pro Asp Ile Pro Thr 
                485                 490                 495     


Pro Val Leu Ser Leu Ser Met Leu Ser Ile Thr Tyr His Ser Ser Ile 
            500                 505                 510         


Arg Ser Leu Glu Val Gln Cys Gly Ala Gly Leu Thr Leu Leu Trp Ser 
        515                 520                 525             


Pro Pro Asp His Met Tyr Leu Tyr Gln His Val Leu Ala Thr Leu Gln 
    530                 535                 540                 


Cys Arg Asp Leu Leu Arg Ala Thr Val Phe Pro Glu Thr Val Pro Ser 
545                 550                 555                 560 


Leu Ala Leu Glu Thr Ser Gly Thr Thr Ser Glu Leu Glu Gly Arg Ala 
                565                 570                 575     


Pro Glu Pro Leu Pro Pro Lys Arg Leu Leu Asn Leu Thr Leu Glu Val 
            580                 585                 590         


Ser Thr Ala Lys Leu Thr Ala Phe Val Ala Glu Asp Lys Phe Ile Thr 
        595                 600                 605             


Leu Ala Ala Glu Ser Val Ser Leu Ser Arg His Gly Gly Ser Leu Gln 
    610                 615                 620                 


Ala Tyr Cys Pro Glu Leu Ala Ala Gly Phe Asp Gly Asn Ser Ile Phe 
625                 630                 635                 640 


Asn Phe Lys Glu Val Glu Val Gln Leu Leu Pro Glu Leu Glu Glu Met 
                645                 650                 655     


Ile Leu His Arg Asn Pro Phe Pro Ala Leu Gln Thr Leu Arg Asn Arg 
            660                 665                 670         


Val Trp Leu Leu Ser Phe Gly Ser Val Ser Val Glu Phe Pro Tyr Gln 
        675                 680                 685             


Tyr Asp Phe Ser Arg Thr Leu Asp Glu Ala Val Gly Val Gln Lys Trp 
    690                 695                 700                 


Leu Lys Gly Leu His Gln Gly Thr Arg Ala Trp Ala Ser Pro Ser Pro 
705                 710                 715                 720 


Val Pro Leu Pro Pro Asp Leu Leu Leu Lys Val Glu His Phe Ser Trp 
                725                 730                 735     


Val Phe Leu Asp Asp Val Phe Glu Val Lys Leu His Asp Asn Tyr Glu 
            740                 745                 750         


Leu Met Lys Asp Glu Ser Lys Glu Ser Ala Lys Arg Leu Gln Leu Leu 
        755                 760                 765             


Asp Ala Lys Val Ala Ala Leu Arg Lys Gln His Gly Glu Leu Leu Pro 
    770                 775                 780                 


Ala Arg Lys Ile Glu Glu Leu Tyr Ala Ser Leu Glu Arg Lys Asn Ile 
785                 790                 795                 800 


Glu Ile Tyr Ile Gln Arg Ser Arg Arg Leu Tyr Gly Asn Thr Pro Met 
                805                 810                 815     


Arg Arg Ala Leu Leu Thr Trp Ser Leu Ala Gly Leu Glu Leu Val Ala 
            820                 825                 830         


Leu Ala Asp Ala Ser Phe His Gly Pro Glu His Val Val Glu Gln Val 
        835                 840                 845             


Gln Glu Leu Asp Pro Gly Ser Pro Phe Pro Pro Glu Gly Leu Asp Leu 
    850                 855                 860                 


Val Ile Gln Trp Cys Arg Met Leu Lys Cys Asn Val Lys Ser Phe Leu 
865                 870                 875                 880 


Val Arg Ile Arg Asp Tyr Pro Arg Tyr Leu Phe Glu Ile Arg Asp Trp 
                885                 890                 895     


Arg Leu Met Gly Arg Leu Val Gly Thr Glu Gln Ser Gly Gln Pro Cys 
            900                 905                 910         


Ser Arg Arg Arg Gln Ile Leu His Leu Gly Leu Pro Trp Gly Asn Val 
        915                 920                 925             


Ala Val Glu Arg Asn Met Pro Pro Leu Lys Phe Tyr His Asp Phe His 
    930                 935                 940                 


Ser Glu Ile Phe Gln Tyr Thr Val Val Trp Gly Pro Cys Trp Asp Pro 
945                 950                 955                 960 


Ala Trp Thr Leu Ile Gly Gln Cys Val Asp Leu Leu Thr Lys Pro Ser 
                965                 970                 975     


Ala Asp Pro Ser Pro Pro Leu Pro Trp Trp Asp Lys Ser Arg Leu Leu 
            980                 985                 990         


Phe His Gly Asp Trp His Met Asp  Ile Glu Gln Ala Asn  Leu His Gln 
        995                 1000                 1005             


Leu Ala  Thr Glu Asp Pro Tyr  Asn Thr Thr Glu Asn  Met His Trp 
    1010                 1015                 1020             


Glu Trp  Ser His Leu Ser Phe  His Trp Lys Pro Gly  Gln Phe Val 
    1025                 1030                 1035             


Phe Lys  Gly Asp Leu Asp Ile  Asn Val Arg Thr Ala  Ser Lys Tyr 
    1040                 1045                 1050             


Asp Asp  Cys Cys Phe Leu His  Leu Pro Asp Leu Cys  Met Thr Leu 
    1055                 1060                 1065             


Asp Leu  Gln Trp Leu Cys His  Gly Asn Pro His Asp  His His Ser 
    1070                 1075                 1080             


Val Thr  Leu Arg Ala Pro Glu  Phe Leu Pro Glu Val  Pro Leu Gly 
    1085                 1090                 1095             


Gln Leu  His Asp Ser Tyr Arg  Ala Phe Arg Ser Glu  Asn Leu Asn 
    1100                 1105                 1110             


Leu Ser  Ile Lys Met Asp Leu  Thr Arg His Ser Gly  Thr Ile Ser 
    1115                 1120                 1125             


Gln Pro  Arg Ile Leu Leu Tyr  Ser Ser Thr Leu Arg  Trp Met Gln 
    1130                 1135                 1140             


Asn Phe  Trp Ala Thr Trp Thr  Ser Val Thr Arg Pro  Ile Cys Arg 
    1145                 1150                 1155             


Gly Lys  Leu Phe Asn Asn Leu  Lys Pro Ser Lys Lys  Lys Leu Gly 
    1160                 1165                 1170             


Gln His  Tyr Lys Gln Leu Ser  Tyr Thr Ala Leu Phe  Pro Gln Leu 
    1175                 1180                 1185             


Gln Val  His Tyr Trp Ala Ser  Phe Ala Gln Gln Arg  Gly Ile Gln 
    1190                 1195                 1200             


Ile Glu  Cys Ser Gln Gly His  Val Phe Thr Arg Gly  Thr Gln Arg 
    1205                 1210                 1215             


Leu Ile  Pro Gln Ala Gly Thr  Val Met Arg Arg Leu  Ile Ser Asp 
    1220                 1225                 1230             


Trp Ser  Val Thr Gln Met Val  Ser Asp Leu Ser Gln  Val Thr Val 
    1235                 1240                 1245             


His Leu  Met Ala Ser Pro Thr  Glu Glu Asn Ala Asp  His Cys Leu 
    1250                 1255                 1260             


Asp Pro  Leu Val Thr Lys Thr  His Leu Leu Ser Leu  Ser Ser Leu 
    1265                 1270                 1275             


Thr Tyr  Gln Arg His Ser Asn  Arg Thr Ala Glu Glu  Glu Leu Ser 
    1280                 1285                 1290             


Ala Arg  Asp Gly Asp Pro Thr  Phe His Thr His Gln  Leu His Leu 
    1295                 1300                 1305             


Val Asp  Leu Arg Ile Ser Trp  Thr Thr Thr Asn Arg  Asp Ile Ala 
    1310                 1315                 1320             


Phe Gly  Leu Tyr Asp Gly Tyr  Lys Lys Ala Ala Val  Leu Lys Arg 
    1325                 1330                 1335             


Asn Leu  Ser Thr Glu Ala Leu  Lys Gly Leu Lys Ile  Asp Pro Gln 
    1340                 1345                 1350             


Met Pro  Ala Lys Lys Pro Lys  Arg Gly Val Pro Thr  Ser Ala Ser 
    1355                 1360                 1365             


Ala Pro  Pro Arg Val Asn Thr  Pro Ser Phe Ser Gly  Gln Pro Asp 
    1370                 1375                 1380             


Lys Gly  Ser Ser Gly Gly Ala  Tyr Met Leu Gln Lys  Leu Ile Glu 
    1385                 1390                 1395             


Glu Thr  Asp Arg Phe Val Val  Phe Thr Glu Glu Glu  Ser Gly Met 
    1400                 1405                 1410             


Ser Asp  Gln Leu Cys Gly Ile  Ala Ala Cys Gln Thr  Asp Asp Ile 
    1415                 1420                 1425             


Tyr Asn  Arg Asn Cys Leu Ile  Glu Leu Val Asn Cys  Gln Met Val 
    1430                 1435                 1440             


Leu Arg  Gly Ala Glu Thr Glu  Gly Cys Val Ile Val  Ser Ala Ala 
    1445                 1450                 1455             


Lys Ala  Gln Leu Leu Gln Cys  Gln His His Pro Ala  Trp Tyr Gly 
    1460                 1465                 1470             


Asp Thr  Leu Lys Gln Lys Thr  Ser Trp Thr Cys Leu  Leu Asp Gly 
    1475                 1480                 1485             


Met Gln  Tyr Phe Ala Thr Thr  Glu Ser Ser Pro Thr  Glu Gln Asp 
    1490                 1495                 1500             


Gly Arg  Gln Leu Trp Leu Glu  Val Lys Asn Ile Glu  Glu His Arg 
    1505                 1510                 1515             


Gln Arg  Ser Leu Asp Ser Val  Gln Glu Leu Met Glu  Ser Gly Gln 
    1520                 1525                 1530             


Ala Val  Gly Gly Met Val Thr  Thr Thr Thr Asp Trp  Asn Gln Pro 
    1535                 1540                 1545             


Ala Glu  Ala Gln Gln Ala Gln  Gln Val Gln Arg Ile  Ile Ser Arg 
    1550                 1555                 1560             


Cys Asn  Cys Arg Met Tyr Tyr  Ile Ser Tyr Ser His  Asp Ile Asp 
    1565                 1570                 1575             


Pro Glu  Leu Ala Thr Gln Ile  Lys Pro Pro Glu Val  Leu Glu Asn 
    1580                 1585                 1590             


Gln Glu  Lys Glu Asp Leu Leu  Lys Lys Gln Glu Gly  Ala Val Asp 
    1595                 1600                 1605             


Thr Phe  Thr Leu Ile His His  Glu Leu Glu Ile Ser  Thr Asn Pro 
    1610                 1615                 1620             


Ala Gln  Tyr Ala Met Ile Leu  Asp Ile Val Asn Asn  Leu Leu Leu 
    1625                 1630                 1635             


His Val  Glu Pro Lys Arg Lys  Glu His Ser Glu Lys  Lys Gln Arg 
    1640                 1645                 1650             


Val Arg  Phe Gln Leu Glu Ile  Ser Ser Asn Pro Glu  Glu Gln Arg 
    1655                 1660                 1665             


Ser Ser  Ile Leu His Leu Gln  Glu Ala Val Arg Gln  His Val Ala 
    1670                 1675                 1680             


Gln Ile  Arg Gln Leu Glu Lys  Gln Met Tyr Ser Ile  Met Lys Ser 
    1685                 1690                 1695             


Leu Gln  Asp Asp Ser Lys Asn  Glu Asn Leu Leu Asp  Leu Asn Gln 
    1700                 1705                 1710             


Lys Leu  Gln Leu Gln Leu Asn  Gln Glu Lys Ala Asn  Leu Gln Leu 
    1715                 1720                 1725             


Glu Ser  Glu Glu Leu Asn Ile  Leu Ile Arg Cys Phe  Lys Asp Phe 
    1730                 1735                 1740             


Gln Leu  Gln Arg Ala Asn Lys  Met Glu Leu Arg Lys  Gln Gln Glu 
    1745                 1750                 1755             


Asp Val  Ser Val Val Arg Arg  Thr Glu Phe Tyr Phe  Ala Gln Ala 
    1760                 1765                 1770             


Arg Trp  Arg Leu Thr Glu Glu  Asp Gly Gln Leu Gly  Ile Ala Glu 
    1775                 1780                 1785             


Leu Glu  Leu Gln Arg Phe Leu  Tyr Ser Lys Val Asn  Lys Ser Asp 
    1790                 1795                 1800             


Asp Thr  Ala Glu His Leu Leu  Glu Leu Gly Trp Phe  Thr Met Asn 
    1805                 1810                 1815             


Asn Leu  Leu Pro Asn Ala Val  Tyr Lys Ala Ile Leu  Arg Pro Gln 
    1820                 1825                 1830             


Ser Ser  Cys Gln Ser Gly Arg  Gln Leu Ala Leu Arg  Leu Phe Ser 
    1835                 1840                 1845             


Lys Val  Arg Pro Pro Val Gly  Gly Ile Ser Val Lys  Glu His Phe 
    1850                 1855                 1860             


Glu Val  Asn Val Val Pro Leu  Thr Ile Gln Leu Thr  His Gln Phe 
    1865                 1870                 1875             


Phe His  Arg Met Met Gly Phe  Phe Phe Pro Gly Arg  Ser Val Glu 
    1880                 1885                 1890             


Asp Asp  Glu Val Gly Asp Glu  Glu Asp Lys Ser Lys  Leu Val Thr 
    1895                 1900                 1905             


Thr Gly  Ile Pro Val Val Lys  Pro Arg Gln Leu Ile  Ala Thr Asp 
    1910                 1915                 1920             


Asp Ala  Val Pro Leu Gly Pro  Gly Lys Gly Val Ala  Gln Gly Leu 
    1925                 1930                 1935             


Thr Arg  Ser Ser Gly Val Arg  Arg Ser Phe Arg Lys  Ser Pro Glu 
    1940                 1945                 1950             


His Pro  Val Asp Asp Ile Asp  Lys Met Lys Glu Arg  Ala Ala Met 
    1955                 1960                 1965             


Asn Asn  Ser Phe Ile Tyr Ile  Lys Ile Pro Gln Val  Pro Leu Cys 
    1970                 1975                 1980             


Val Ser  Tyr Lys Gly Glu Lys  Asn Ser Val Asp Trp  Gly Asp Leu 
    1985                 1990                 1995             


Asn Leu  Val Leu Pro Cys Leu  Glu Tyr His Asn Asn  Thr Trp Thr 
    2000                 2005                 2010             


Trp Leu  Asp Phe Ala Met Ala  Val Lys Arg Asp Ser  Arg Lys Ala 
    2015                 2020                 2025             


Leu Val  Ala Gln Val Ile Lys  Glu Lys Leu Arg Leu  Lys Ser Ala 
    2030                 2035                 2040             


Thr Gly  Ser Glu Val Arg Gly  Lys Leu Glu Thr Lys  Ser Asp Leu 
    2045                 2050                 2055             


Asn Met  Gln Gln Gln Glu Glu  Glu Glu Lys Ala Arg  Leu Leu Ile 
    2060                 2065                 2070             


Gly Leu  Ser Val Gly Asp Lys  Asn Pro Gly Lys Lys  Ser Ile Phe 
    2075                 2080                 2085             


Gly Arg  Arg Lys 
    2090         


<210>  7442
<211>  2092
<212>  PRT
<213>  Homo Sapiens

<400>  7442

Met Val Leu Lys Val Asp Thr Ser Glu Ser Leu Trp His Ile Gln Ile 
1               5                   10                  15      


Ser Arg Ser Arg Phe Leu Leu Asp Ser Asp Gly Lys Arg Leu Ile Cys 
            20                  25                  30          


Glu Val Ser Leu Cys Lys Ile Asn Ser Lys Val Leu Lys Ser Gly Gln 
        35                  40                  45              


Leu Glu Asp Thr Cys Leu Val Glu Leu Ser Leu Ala Leu Asp Leu Cys 
    50                  55                  60                  


Leu Lys Val Gly Ile Ser Ser Arg His Leu Thr Ala Ile Thr Val Asp 
65                  70                  75                  80  


Val Trp Thr Leu His Ala Glu Leu His Glu Gly Leu Phe Gln Ser Gln 
                85                  90                  95      


Leu Leu Cys Gln Gly Pro Ser Leu Ala Ser Lys Pro Val Pro Cys Ser 
            100                 105                 110         


Glu Val Thr Glu Asn Leu Val Glu Pro Thr Leu Pro Gly Leu Phe Leu 
        115                 120                 125             


Leu Gln Gln Leu Pro Asp Gln Val Lys Val Lys Met Glu Asn Thr Ser 
    130                 135                 140                 


Val Val Leu Ser Met Asn Ser Gln Lys Arg His Leu Thr Trp Thr Leu 
145                 150                 155                 160 


Lys Leu Leu Gln Phe Leu Tyr His Arg Asp Glu Asp Gln Leu Pro Leu 
                165                 170                 175     


Arg Ser Phe Thr Ala Asn Ser Asp Met Ala Gln Met Ser Thr Glu Leu 
            180                 185                 190         


Leu Leu Glu Asp Gly Leu Leu Leu Ser Gln Ser Arg Gln Arg Ile Val 
        195                 200                 205             


Cys Leu Asn Ser Leu Lys Ala Ser Val Gln Val Thr Thr Ile Asp Leu 
    210                 215                 220                 


Ser Ala Ser Leu Val Leu Asn Thr Cys Ile Ile His Tyr Arg His Gln 
225                 230                 235                 240 


Glu Phe Ser His Trp Leu His Leu Leu Ala Leu Glu Thr Gln Gly Ser 
                245                 250                 255     


Ser Ser Pro Val Leu Lys Gln Arg Lys Lys Arg Thr Phe Pro Gln Ile 
            260                 265                 270         


Leu Ala Pro Ile Ile Phe Ser Thr Ser Ile Ser Asn Val Asn Ile Ser 
        275                 280                 285             


Ile Gln Leu Gly Asp Thr Pro Pro Phe Ala Leu Gly Phe Asn Ser Ile 
    290                 295                 300                 


Ser Leu Asp Tyr Gln His Leu Arg Pro Gln Ser Ile His Gln Arg Gly 
305                 310                 315                 320 


Val Leu Thr Val Asp His Leu Cys Trp Arg Val Gly Ser Asp Ser His 
                325                 330                 335     


Ile Gln Arg Ala Pro His Pro Pro Asn Met His Val Trp Gly Glu Ala 
            340                 345                 350         


Leu Val Leu Asp Ser Phe Thr Leu Gln Gly Ser Tyr Asn Gln Pro Leu 
        355                 360                 365             


Gly Leu Ser Ser Thr Gln Ser Asp Thr Leu Phe Leu Asp Cys Thr Ile 
    370                 375                 380                 


Arg Gly Leu Gln Val Glu Ala Ser Asp Thr Cys Ala Gln Cys Leu Ser 
385                 390                 395                 400 


Arg Ile Leu Ser Leu Met Gly Pro Gln Ser Gly Lys Ser Ala Val Ser 
                405                 410                 415     


Arg His Ser Ser Phe Gly Glu Ser Val Ser Leu Leu Trp Lys Val Asp 
            420                 425                 430         


Leu Lys Val Glu Asp Met Asn Leu Phe Thr Leu Ser Ala Leu Val Gly 
        435                 440                 445             


Ala Ser Glu Val Arg Leu Asp Thr Leu Thr Ile Leu Gly Ser Ala Glu 
    450                 455                 460                 


Thr Ser Thr Val Gly Ile Gln Gly Leu Val Leu Ala Leu Val Lys Ser 
465                 470                 475                 480 


Val Thr Glu Lys Met Gln Pro Cys Cys Lys Ala Pro Asp Ile Pro Thr 
                485                 490                 495     


Pro Val Leu Ser Leu Ser Met Leu Ser Ile Thr Tyr His Ser Ser Ile 
            500                 505                 510         


Arg Ser Leu Glu Val Gln Cys Gly Ala Gly Leu Thr Leu Leu Trp Ser 
        515                 520                 525             


Pro Pro Asp His Met Tyr Leu Tyr Gln His Val Leu Ala Thr Leu Gln 
    530                 535                 540                 


Cys Arg Asp Leu Leu Arg Ala Thr Val Phe Pro Glu Thr Val Pro Ser 
545                 550                 555                 560 


Leu Ala Leu Glu Thr Ser Gly Thr Thr Ser Glu Leu Glu Gly Arg Ala 
                565                 570                 575     


Pro Glu Pro Leu Pro Pro Lys Arg Leu Leu Asn Leu Thr Leu Glu Val 
            580                 585                 590         


Ser Thr Ala Lys Leu Thr Ala Phe Val Ala Glu Asp Lys Phe Ile Thr 
        595                 600                 605             


Leu Ala Ala Glu Ser Val Ser Leu Ser Arg His Gly Gly Ser Leu Gln 
    610                 615                 620                 


Ala Tyr Cys Pro Glu Leu Ala Ala Gly Phe Asp Gly Asn Ser Ile Phe 
625                 630                 635                 640 


Asn Phe Lys Glu Val Glu Val Gln Leu Leu Pro Glu Leu Glu Glu Met 
                645                 650                 655     


Ile Leu His Arg Asn Pro Phe Pro Ala Leu Gln Thr Leu Arg Asn Arg 
            660                 665                 670         


Val Trp Leu Leu Ser Phe Gly Ser Val Ser Val Glu Phe Pro Tyr Gln 
        675                 680                 685             


Tyr Asp Phe Ser Arg Thr Leu Asp Glu Ala Val Gly Val Gln Lys Trp 
    690                 695                 700                 


Leu Lys Gly Leu His Gln Gly Thr Arg Ala Trp Ala Ser Pro Ser Pro 
705                 710                 715                 720 


Val Pro Leu Pro Pro Asp Leu Leu Leu Lys Val Glu His Phe Ser Trp 
                725                 730                 735     


Val Phe Leu Asp Asp Val Phe Glu Val Lys Leu His Asp Asn Tyr Glu 
            740                 745                 750         


Leu Met Lys Asp Glu Ser Lys Glu Ser Ala Lys Arg Leu Gln Leu Leu 
        755                 760                 765             


Asp Ala Lys Val Ala Ala Leu Arg Lys Gln His Gly Glu Leu Leu Pro 
    770                 775                 780                 


Ala Arg Lys Ile Glu Glu Leu Tyr Ala Ser Leu Glu Arg Lys Asn Ile 
785                 790                 795                 800 


Glu Ile Tyr Ile Gln Arg Ser Arg Arg Leu Tyr Gly Asn Thr Pro Met 
                805                 810                 815     


Arg Arg Ala Leu Leu Thr Trp Ser Leu Ala Gly Leu Glu Leu Val Ala 
            820                 825                 830         


Leu Ala Asp Ala Ser Phe His Gly Pro Glu His Val Val Glu Gln Val 
        835                 840                 845             


Gln Glu Leu Asp Pro Gly Ser Pro Phe Pro Pro Glu Gly Leu Asp Leu 
    850                 855                 860                 


Val Ile Gln Trp Cys Arg Met Leu Lys Cys Asn Val Lys Ser Phe Leu 
865                 870                 875                 880 


Val Arg Ile Arg Asp Tyr Pro Arg Tyr Leu Phe Glu Ile Arg Asp Trp 
                885                 890                 895     


Arg Leu Met Gly Arg Leu Val Gly Thr Glu Gln Ser Gly Gln Pro Cys 
            900                 905                 910         


Ser Arg Arg Arg Gln Ile Leu His Leu Gly Leu Pro Trp Gly Asn Val 
        915                 920                 925             


Ala Val Glu Arg Asn Met Pro Pro Leu Lys Phe Tyr His Asp Phe His 
    930                 935                 940                 


Ser Glu Ile Phe Gln Tyr Thr Val Val Trp Gly Pro Cys Trp Asp Pro 
945                 950                 955                 960 


Ala Trp Thr Leu Ile Gly Gln Cys Val Asp Leu Leu Thr Lys Pro Ser 
                965                 970                 975     


Ala Asp Pro Ser Pro Pro Leu Pro Trp Trp Asp Lys Ser Arg Leu Leu 
            980                 985                 990         


Phe His Gly Asp Trp His Met Asp  Ile Glu Gln Ala Asn  Leu His Gln 
        995                 1000                 1005             


Leu Ala  Thr Glu Asp Pro Tyr  Asn Thr Thr Glu Asn  Met His Trp 
    1010                 1015                 1020             


Glu Trp  Ser His Leu Ser Phe  His Trp Lys Pro Gly  Gln Phe Val 
    1025                 1030                 1035             


Phe Lys  Gly Asp Leu Asp Ile  Asn Val Arg Thr Ala  Ser Lys Tyr 
    1040                 1045                 1050             


Asp Asp  Cys Cys Phe Leu His  Leu Pro Asp Leu Cys  Met Thr Leu 
    1055                 1060                 1065             


Asp Leu  Gln Trp Leu Cys His  Gly Asn Pro His Asp  His His Ser 
    1070                 1075                 1080             


Val Thr  Leu Arg Ala Pro Glu  Phe Leu Pro Glu Val  Pro Leu Gly 
    1085                 1090                 1095             


Gln Leu  His Asp Ser Tyr Arg  Ala Phe Arg Ser Glu  Asn Leu Asn 
    1100                 1105                 1110             


Leu Ser  Ile Lys Met Asp Leu  Thr Arg His Ser Gly  Thr Ile Ser 
    1115                 1120                 1125             


Gln Pro  Arg Ile Leu Leu Tyr  Ser Ser Thr Leu Arg  Trp Met Gln 
    1130                 1135                 1140             


Asn Phe  Trp Ala Thr Trp Thr  Ser Val Thr Arg Pro  Ile Cys Arg 
    1145                 1150                 1155             


Gly Lys  Leu Phe Asn Asn Leu  Lys Pro Ser Lys Lys  Lys Leu Gly 
    1160                 1165                 1170             


Gln His  Tyr Lys Gln Leu Ser  Tyr Thr Ala Leu Phe  Pro Gln Leu 
    1175                 1180                 1185             


Gln Val  His Tyr Trp Ala Ser  Phe Ala Gln Gln Arg  Gly Ile Gln 
    1190                 1195                 1200             


Ile Glu  Cys Ser Gln Gly His  Val Phe Thr Arg Gly  Thr Gln Arg 
    1205                 1210                 1215             


Leu Ile  Pro Gln Ala Gly Thr  Val Met Arg Arg Leu  Ile Ser Asp 
    1220                 1225                 1230             


Trp Ser  Val Thr Gln Met Val  Ser Asp Leu Ser Gln  Val Thr Val 
    1235                 1240                 1245             


His Leu  Met Ala Ser Pro Thr  Glu Glu Asn Ala Asp  His Cys Leu 
    1250                 1255                 1260             


Asp Pro  Leu Val Thr Lys Thr  His Leu Leu Ser Leu  Ser Ser Leu 
    1265                 1270                 1275             


Thr Tyr  Gln Arg His Ser Asn  Arg Thr Ala Glu Glu  Glu Leu Ser 
    1280                 1285                 1290             


Ala Arg  Asp Gly Asp Pro Thr  Phe His Thr His Gln  Leu His Leu 
    1295                 1300                 1305             


Val Asp  Leu Arg Ile Ser Trp  Thr Thr Thr Asn Arg  Asp Ile Ala 
    1310                 1315                 1320             


Phe Gly  Leu Tyr Asp Gly Tyr  Lys Lys Ala Ala Val  Leu Lys Arg 
    1325                 1330                 1335             


Asn Leu  Ser Thr Glu Ala Leu  Lys Gly Leu Lys Ile  Asp Pro Gln 
    1340                 1345                 1350             


Met Pro  Ala Lys Lys Pro Lys  Arg Gly Val Pro Thr  Ser Ala Ser 
    1355                 1360                 1365             


Ala Pro  Pro Arg Val Asn Thr  Pro Ser Phe Ser Gly  Gln Pro Asp 
    1370                 1375                 1380             


Lys Gly  Ser Ser Gly Gly Ala  Tyr Met Leu Gln Lys  Leu Ile Glu 
    1385                 1390                 1395             


Glu Thr  Asp Arg Phe Val Val  Phe Thr Glu Glu Glu  Ser Gly Met 
    1400                 1405                 1410             


Ser Asp  Gln Leu Cys Gly Ile  Ala Ala Cys Gln Thr  Asp Asp Ile 
    1415                 1420                 1425             


Tyr Asn  Arg Asn Cys Leu Ile  Glu Leu Val Asn Cys  Gln Met Val 
    1430                 1435                 1440             


Leu Arg  Gly Ala Glu Thr Glu  Gly Cys Val Ile Val  Ser Ala Ala 
    1445                 1450                 1455             


Lys Ala  Gln Leu Leu Gln Cys  Gln His His Pro Ala  Trp Tyr Gly 
    1460                 1465                 1470             


Asp Thr  Leu Lys Gln Lys Thr  Ser Trp Thr Cys Leu  Leu Asp Gly 
    1475                 1480                 1485             


Met Gln  Tyr Phe Ala Thr Thr  Glu Ser Ser Pro Thr  Glu Gln Asp 
    1490                 1495                 1500             


Gly Arg  Gln Leu Trp Leu Glu  Val Lys Asn Ile Glu  Glu His Arg 
    1505                 1510                 1515             


Gln Arg  Ser Leu Asp Ser Val  Gln Glu Leu Met Glu  Ser Gly Gln 
    1520                 1525                 1530             


Ala Val  Gly Gly Met Val Thr  Thr Thr Thr Asp Trp  Asn Gln Pro 
    1535                 1540                 1545             


Ala Glu  Ala Gln Gln Ala Gln  Gln Val Gln Arg Ile  Ile Ser Arg 
    1550                 1555                 1560             


Cys Asn  Cys Arg Met Tyr Tyr  Ile Ser Tyr Ser His  Asp Ile Asp 
    1565                 1570                 1575             


Pro Glu  Leu Ala Thr Gln Ile  Lys Pro Pro Glu Val  Leu Glu Asn 
    1580                 1585                 1590             


Gln Glu  Lys Glu Asp Leu Leu  Lys Lys Gln Glu Gly  Ala Val Asp 
    1595                 1600                 1605             


Thr Phe  Thr Leu Ile His His  Glu Leu Glu Ile Ser  Thr Asn Pro 
    1610                 1615                 1620             


Ala Gln  Tyr Ala Met Ile Leu  Asp Ile Val Asn Asn  Leu Leu Leu 
    1625                 1630                 1635             


His Val  Glu Pro Lys Arg Lys  Glu His Ser Glu Lys  Lys Gln Arg 
    1640                 1645                 1650             


Val Arg  Phe Gln Leu Glu Ile  Ser Ser Asn Pro Glu  Glu Gln Arg 
    1655                 1660                 1665             


Ser Ser  Ile Leu His Leu Gln  Glu Ala Val Arg Gln  His Val Ala 
    1670                 1675                 1680             


Gln Ile  Arg Gln Leu Glu Lys  Gln Met Tyr Ser Ile  Met Lys Ser 
    1685                 1690                 1695             


Leu Gln  Asp Asp Ser Lys Asn  Glu Asn Leu Leu Asp  Leu Asn Gln 
    1700                 1705                 1710             


Lys Leu  Gln Leu Gln Leu Asn  Gln Glu Lys Ala Asn  Leu Gln Leu 
    1715                 1720                 1725             


Glu Ser  Glu Glu Leu Asn Ile  Leu Ile Arg Cys Phe  Lys Asp Phe 
    1730                 1735                 1740             


Gln Leu  Gln Arg Ala Asn Lys  Met Glu Leu Arg Lys  Gln Gln Glu 
    1745                 1750                 1755             


Asp Val  Ser Val Val Arg Arg  Thr Glu Phe Tyr Phe  Ala Gln Ala 
    1760                 1765                 1770             


Arg Trp  Arg Leu Thr Glu Glu  Asp Gly Gln Leu Gly  Ile Ala Glu 
    1775                 1780                 1785             


Leu Glu  Leu Gln Arg Phe Leu  Tyr Ser Lys Val Asn  Lys Ser Asp 
    1790                 1795                 1800             


Asp Thr  Ala Glu His Leu Leu  Glu Leu Gly Trp Phe  Thr Met Asn 
    1805                 1810                 1815             


Asn Leu  Leu Pro Asn Ala Val  Tyr Lys Val Val Leu  Arg Pro Gln 
    1820                 1825                 1830             


Ser Ser  Cys Gln Ser Gly Arg  Gln Leu Ala Leu Arg  Leu Phe Ser 
    1835                 1840                 1845             


Lys Val  Arg Pro Pro Val Gly  Gly Ile Ser Val Lys  Glu His Phe 
    1850                 1855                 1860             


Glu Val  Asn Val Val Pro Leu  Thr Ile Gln Leu Thr  His Gln Phe 
    1865                 1870                 1875             


Phe His  Arg Met Met Gly Phe  Phe Phe Pro Gly Arg  Ser Val Glu 
    1880                 1885                 1890             


Asp Asp  Glu Val Gly Asp Glu  Glu Asp Lys Ser Lys  Leu Val Thr 
    1895                 1900                 1905             


Thr Gly  Ile Pro Val Val Lys  Pro Arg Gln Leu Ile  Ala Thr Asp 
    1910                 1915                 1920             


Asp Ala  Val Pro Leu Gly Pro  Gly Lys Gly Val Ala  Gln Gly Leu 
    1925                 1930                 1935             


Thr Arg  Ser Ser Gly Val Arg  Arg Ser Phe Arg Lys  Ser Pro Glu 
    1940                 1945                 1950             


His Pro  Val Asp Asp Ile Asp  Lys Met Lys Glu Arg  Ala Ala Met 
    1955                 1960                 1965             


Asn Asn  Ser Phe Ile Tyr Ile  Lys Ile Pro Gln Val  Pro Leu Cys 
    1970                 1975                 1980             


Val Ser  Tyr Lys Gly Glu Lys  Asn Ser Val Asp Trp  Gly Asp Leu 
    1985                 1990                 1995             


Asn Leu  Val Leu Pro Cys Leu  Glu Tyr His Asn Asn  Thr Trp Thr 
    2000                 2005                 2010             


Trp Leu  Asp Phe Ala Met Ala  Val Lys Arg Asp Ser  Arg Lys Ala 
    2015                 2020                 2025             


Leu Val  Ala Gln Val Ile Lys  Glu Lys Leu Arg Leu  Lys Ser Ala 
    2030                 2035                 2040             


Thr Gly  Ser Glu Val Arg Gly  Lys Leu Glu Thr Lys  Ser Asp Leu 
    2045                 2050                 2055             


Asn Met  Gln Gln Gln Glu Glu  Glu Glu Lys Ala Arg  Leu Leu Ile 
    2060                 2065                 2070             


Gly Leu  Ser Val Gly Asp Lys  Asn Pro Gly Lys Lys  Ser Ile Phe 
    2075                 2080                 2085             


Gly Arg  Arg Lys 
    2090         


<210>  7443
<211>  21
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7443

Xaa Gln Gly Pro Ser Leu Ala Ser Lys Pro Val Pro Cys Ser Ala Ala 
1               5                   10                  15      


Arg Pro Gly Gln Gly 
            20      


<210>  7444
<211>  1072
<212>  PRT
<213>  Homo Sapiens

<400>  7444

Met Ala Pro Pro Thr Gly Val Leu Ser Ser Leu Leu Leu Leu Val Thr 
1               5                   10                  15      


Ile Ala Gly Cys Ala Arg Lys Gln Cys Ser Glu Gly Arg Thr Tyr Ser 
            20                  25                  30          


Asn Ala Val Ile Ser Pro Asn Leu Glu Thr Thr Arg Ile Met Arg Val 
        35                  40                  45              


Ser His Thr Phe Pro Val Val Asp Cys Thr Ala Ala Cys Cys Asp Leu 
    50                  55                  60                  


Ser Ser Cys Asp Leu Ala Trp Trp Phe Glu Gly Arg Cys Tyr Leu Val 
65                  70                  75                  80  


Ser Cys Pro His Lys Glu Asn Cys Glu Pro Lys Lys Met Gly Pro Ile 
                85                  90                  95      


Arg Ser Tyr Leu Thr Phe Val Leu Arg Pro Val Gln Arg Pro Ala Gln 
            100                 105                 110         


Leu Leu Asp Tyr Gly Asp Met Met Leu Asn Arg Gly Ser Pro Ser Gly 
        115                 120                 125             


Ile Trp Gly Asp Ser Pro Glu Asp Ile Arg Lys Asp Leu Thr Phe Leu 
    130                 135                 140                 


Gly Lys Asp Trp Gly Leu Glu Glu Met Ser Glu Tyr Ser Asp Asp Tyr 
145                 150                 155                 160 


Arg Glu Leu Glu Lys Asp Leu Leu Gln Pro Ser Gly Lys Gln Glu Pro 
                165                 170                 175     


Arg Gly Ser Ala Glu Tyr Thr Asp Trp Gly Leu Leu Pro Gly Ser Glu 
            180                 185                 190         


Gly Ala Phe Asn Ser Ser Val Gly Asp Ser Pro Ala Val Pro Ala Glu 
        195                 200                 205             


Thr Gln Gln Asp Pro Glu Leu His Tyr Leu Asn Glu Ser Ala Ser Thr 
    210                 215                 220                 


Pro Ala Pro Lys Leu Pro Glu Arg Ser Val Leu Leu Pro Leu Pro Thr 
225                 230                 235                 240 


Thr Pro Ser Ser Gly Glu Val Leu Glu Lys Glu Lys Ala Ser Gln Leu 
                245                 250                 255     


Gln Glu Gln Ser Ser Asn Ser Ser Gly Lys Glu Val Leu Met Pro Ser 
            260                 265                 270         


His Ser Leu Pro Pro Ala Ser Leu Glu Leu Ser Ser Val Thr Val Glu 
        275                 280                 285             


Lys Ser Pro Val Leu Thr Val Thr Pro Gly Ser Thr Glu His Ser Ile 
    290                 295                 300                 


Pro Thr Pro Pro Thr Ser Ala Ala Pro Ser Glu Ser Thr Pro Ser Glu 
305                 310                 315                 320 


Leu Pro Ile Ser Pro Thr Thr Ala Pro Arg Thr Val Lys Glu Leu Thr 
                325                 330                 335     


Val Ser Ala Gly Asp Asn Leu Ile Ile Thr Leu Pro Asp Asn Glu Val 
            340                 345                 350         


Glu Leu Lys Ala Phe Val Ala Pro Ala Pro Pro Val Glu Thr Thr Tyr 
        355                 360                 365             


Asn Tyr Glu Trp Asn Leu Ile Ser His Pro Thr Asp Tyr Gln Gly Glu 
    370                 375                 380                 


Ile Lys Gln Gly His Lys Gln Thr Leu Asn Leu Ser Gln Leu Ser Val 
385                 390                 395                 400 


Gly Leu Tyr Val Phe Lys Val Thr Val Ser Ser Glu Asn Ala Phe Gly 
                405                 410                 415     


Glu Gly Phe Val Asn Val Thr Val Lys Pro Ala Arg Arg Val Asn Leu 
            420                 425                 430         


Pro Pro Val Ala Val Val Ser Pro Gln Leu Gln Glu Leu Thr Leu Pro 
        435                 440                 445             


Leu Thr Ser Ala Leu Ile Asp Gly Ser Gln Ser Thr Asp Asp Thr Glu 
    450                 455                 460                 


Ile Val Ser Tyr His Trp Glu Glu Ile Asn Gly Pro Phe Ile Glu Glu 
465                 470                 475                 480 


Lys Thr Ser Val Asp Ser Pro Val Leu Arg Leu Ser Asn Leu Asp Pro 
                485                 490                 495     


Gly Asn Tyr Ser Phe Arg Leu Thr Val Thr Asp Ser Asp Gly Ala Thr 
            500                 505                 510         


Asn Ser Thr Thr Ala Ala Leu Ile Val Asn Asn Ala Val Asp Tyr Pro 
        515                 520                 525             


Pro Val Ala Asn Ala Gly Pro Asn His Thr Ile Thr Leu Pro Gln Asn 
    530                 535                 540                 


Ser Ile Thr Leu Asn Gly Asn Gln Ser Ser Asp Asp His Gln Ile Val 
545                 550                 555                 560 


Leu Tyr Glu Trp Ser Leu Gly Pro Gly Ser Glu Gly Lys His Val Val 
                565                 570                 575     


Met Gln Gly Val Gln Thr Pro Tyr Leu His Leu Ser Ala Met Gln Glu 
            580                 585                 590         


Gly Asp Tyr Thr Phe Gln Leu Lys Val Thr Asp Ser Ser Arg Gln Gln 
        595                 600                 605             


Ser Thr Ala Val Val Thr Val Ile Val Gln Pro Glu Asn Asn Arg Pro 
    610                 615                 620                 


Pro Val Ala Val Ala Gly Pro Asp Lys Glu Leu Ile Phe Pro Val Glu 
625                 630                 635                 640 


Ser Ala Thr Leu Asp Gly Ser Ser Ser Ser Asp Asp His Gly Ile Val 
                645                 650                 655     


Phe Tyr His Trp Glu His Val Arg Gly Pro Ser Ala Val Glu Met Glu 
            660                 665                 670         


Asn Ile Asp Lys Ala Ile Ala Thr Val Thr Gly Leu Gln Val Gly Thr 
        675                 680                 685             


Tyr His Phe Arg Leu Thr Val Lys Asp Gln Gln Gly Leu Ser Ser Thr 
    690                 695                 700                 


Ser Thr Leu Thr Val Ala Val Lys Lys Glu Asn Asn Ser Pro Pro Arg 
705                 710                 715                 720 


Ala Arg Ala Gly Gly Arg His Val Leu Val Leu Pro Asn Asn Ser Ile 
                725                 730                 735     


Thr Leu Asp Gly Ser Arg Ser Thr Asp Asp Gln Arg Ile Val Ser Tyr 
            740                 745                 750         


Leu Trp Ile Arg Asp Gly Gln Ser Pro Ala Ala Gly Asp Val Ile Asp 
        755                 760                 765             


Gly Ser Asp His Ser Val Ala Leu Gln Leu Thr Asn Leu Val Glu Gly 
    770                 775                 780                 


Val Tyr Thr Phe His Leu Arg Val Thr Asp Ser Gln Gly Ala Ser Asp 
785                 790                 795                 800 


Thr Asp Thr Ala Thr Val Glu Val Gln Pro Asp Pro Arg Lys Ser Gly 
                805                 810                 815     


Leu Val Glu Leu Thr Leu Gln Val Gly Val Gly Gln Leu Thr Glu Gln 
            820                 825                 830         


Arg Lys Asp Thr Leu Val Arg Gln Leu Ala Val Leu Leu Asn Val Leu 
        835                 840                 845             


Asp Ser Asp Ile Lys Val Gln Lys Ile Arg Ala His Ser Asp Leu Ser 
    850                 855                 860                 


Thr Val Ile Val Phe Tyr Val Gln Ser Arg Pro Pro Phe Lys Val Leu 
865                 870                 875                 880 


Lys Ala Ala Glu Val Ala Arg Asn Leu His Met Arg Leu Ser Lys Glu 
                885                 890                 895     


Lys Ala Asp Phe Leu Leu Phe Lys Val Leu Arg Val Asp Thr Ala Gly 
            900                 905                 910         


Cys Leu Leu Lys Cys Ser Gly His Gly His Cys Asp Pro Leu Thr Lys 
        915                 920                 925             


Arg Cys Ile Cys Ser His Leu Trp Met Glu Asn Leu Ile Gln Arg Tyr 
    930                 935                 940                 


Ile Trp Asp Gly Glu Ser Asn Cys Glu Trp Ser Ile Phe Tyr Val Thr 
945                 950                 955                 960 


Val Leu Ala Phe Thr Leu Ile Val Leu Thr Gly Gly Phe Thr Trp Leu 
                965                 970                 975     


Cys Ile Cys Cys Cys Lys Arg Gln Lys Arg Thr Lys Ile Arg Lys Lys 
            980                 985                 990         


Thr Lys Tyr Thr Ile Leu Asp Asn  Met Asp Glu Gln Glu  Arg Met Glu 
        995                 1000                 1005             


Leu Arg  Pro Lys Tyr Gly Ile  Lys His Arg Ser Thr  Glu His Asn 
    1010                 1015                 1020             


Ser Ser  Leu Met Val Ser Glu  Ser Glu Phe Asp Ser  Asp Gln Asp 
    1025                 1030                 1035             


Thr Ile  Phe Ser Arg Glu Lys  Met Glu Arg Gly Asn  Pro Lys Val 
    1040                 1045                 1050             


Ser Met  Asn Gly Ser Ile Arg  Asn Gly Ala Ser Phe  Ser Tyr Cys 
    1055                 1060                 1065             


Ser Lys  Asp Arg 
    1070         


<210>  7445
<211>  1011
<212>  PRT
<213>  Homo Sapiens

<400>  7445

Met Ala Pro Pro Thr Gly Val Leu Ser Ser Leu Leu Leu Leu Val Thr 
1               5                   10                  15      


Ile Ala Gly Cys Ala Arg Lys Gln Cys Ser Glu Gly Arg Thr Tyr Ser 
            20                  25                  30          


Asn Ala Val Ile Ser Pro Asn Leu Glu Thr Thr Arg Ile Met Arg Val 
        35                  40                  45              


Ser His Thr Phe Pro Val Val Asp Cys Thr Ala Ala Cys Cys Asp Leu 
    50                  55                  60                  


Ser Ser Cys Asp Leu Ala Trp Trp Phe Glu Gly Arg Cys Tyr Leu Val 
65                  70                  75                  80  


Ser Cys Pro His Lys Glu Asn Cys Glu Pro Lys Lys Met Gly Pro Ile 
                85                  90                  95      


Arg Ser Tyr Leu Thr Phe Val Leu Arg Pro Val Gln Arg Pro Ala Gln 
            100                 105                 110         


Leu Leu Asp Tyr Gly Asp Met Met Leu Asn Arg Gly Ser Pro Ser Gly 
        115                 120                 125             


Ile Trp Gly Asp Ser Pro Glu Asp Ile Arg Lys Asp Leu Thr Phe Leu 
    130                 135                 140                 


Gly Lys Asp Trp Gly Leu Glu Glu Met Ser Glu Tyr Ser Asp Asp Tyr 
145                 150                 155                 160 


Arg Glu Leu Glu Lys Asp Leu Leu Gln Pro Ser Gly Lys Gln Glu Pro 
                165                 170                 175     


Arg Gly Ser Ala Glu Tyr Thr Asp Trp Gly Leu Leu Pro Gly Ser Glu 
            180                 185                 190         


Gly Ala Phe Asn Ser Ser Val Gly Asp Ser Pro Ala Val Pro Ala Glu 
        195                 200                 205             


Thr Gln Gln Asp Pro Glu Leu His Tyr Leu Asn Glu Ser Ala Ser Thr 
    210                 215                 220                 


Pro Ala Pro Lys Leu Pro Glu Arg Ser Val Leu Leu Pro Leu Pro Thr 
225                 230                 235                 240 


Thr Pro Ser Ser Gly Glu Val Leu Glu Lys Glu Lys Ala Ser Gln Leu 
                245                 250                 255     


Gln Glu Gln Ser Ser Asn Ser Ser Gly Lys Glu Val Leu Met Pro Ser 
            260                 265                 270         


His Ser Leu Pro Pro Ala Ser Leu Glu Leu Ser Ser Val Thr Val Glu 
        275                 280                 285             


Lys Ser Pro Val Leu Thr Val Thr Pro Gly Ser Thr Glu His Ser Ile 
    290                 295                 300                 


Pro Thr Pro Pro Thr Ser Ala Ala Pro Ser Glu Ser Thr Pro Ser Glu 
305                 310                 315                 320 


Leu Pro Ile Ser Pro Thr Thr Ala Pro Arg Thr Val Lys Glu Leu Thr 
                325                 330                 335     


Val Ser Ala Gly Asp Asn Leu Ile Ile Thr Leu Pro Asp Asn Glu Val 
            340                 345                 350         


Glu Leu Lys Ala Phe Val Ala Pro Ala Pro Pro Val Glu Thr Thr Tyr 
        355                 360                 365             


Asn Tyr Glu Trp Asn Leu Ile Ser His Pro Thr Asp Tyr Gln Gly Glu 
    370                 375                 380                 


Ile Lys Gln Gly His Lys Gln Thr Leu Asn Leu Ser Gln Leu Ser Val 
385                 390                 395                 400 


Gly Leu Tyr Val Phe Lys Val Thr Val Ser Ser Glu Asn Ala Phe Gly 
                405                 410                 415     


Glu Gly Phe Val Asn Val Thr Val Lys Pro Ala Arg Arg Val Asn Leu 
            420                 425                 430         


Pro Pro Val Ala Val Val Ser Pro Gln Leu Gln Glu Leu Thr Leu Pro 
        435                 440                 445             


Leu Thr Ser Ala Leu Ile Asp Gly Ser Gln Ser Thr Asp Asp Thr Glu 
    450                 455                 460                 


Ile Val Ser Tyr His Trp Glu Glu Ile Asn Gly Pro Phe Ile Glu Glu 
465                 470                 475                 480 


Lys Thr Ser Val Asp Ser Pro Val Leu Arg Leu Ser Asn Leu Asp Pro 
                485                 490                 495     


Gly Asn Tyr Ser Phe Arg Leu Thr Val Thr Asp Ser Asp Gly Ala Thr 
            500                 505                 510         


Asn Ser Thr Thr Ala Ala Leu Ile Val Asn Asn Ala Val Asp Tyr Pro 
        515                 520                 525             


Pro Val Ala Asn Ala Gly Pro Asn His Thr Ile Thr Leu Pro Gln Asn 
    530                 535                 540                 


Ser Ile Thr Leu Asn Gly Asn Gln Ser Ser Asp Asp His Gln Ile Val 
545                 550                 555                 560 


Leu Tyr Glu Trp Ser Leu Gly Pro Gly Ser Glu Gly Lys His Val Val 
                565                 570                 575     


Met Gln Gly Val Gln Thr Pro Tyr Leu His Leu Ser Ala Met Gln Glu 
            580                 585                 590         


Gly Asp Tyr Thr Phe Gln Leu Lys Val Thr Asp Ser Ser Arg Gln Gln 
        595                 600                 605             


Ser Thr Ala Val Val Thr Val Ile Val Gln Pro Glu Asn Asn Arg Pro 
    610                 615                 620                 


Pro Val Ala Val Ala Gly Pro Asp Lys Glu Leu Ile Phe Pro Val Glu 
625                 630                 635                 640 


Ser Ala Thr Leu Asp Gly Ser Ser Ser Ser Asp Asp His Gly Ile Val 
                645                 650                 655     


Phe Tyr His Trp Glu His Val Arg Gly Pro Ser Ala Val Glu Met Glu 
            660                 665                 670         


Asn Ile Asp Lys Ala Ile Ala Thr Val Thr Gly Leu Gln Val Gly Thr 
        675                 680                 685             


Tyr His Phe Arg Leu Thr Val Lys Asp Gln Gln Gly Leu Ser Ser Thr 
    690                 695                 700                 


Ser Thr Leu Thr Val Ala Val Lys Lys Glu Asn Asn Ser Pro Pro Arg 
705                 710                 715                 720 


Ala Arg Ala Gly Gly Arg His Val Leu Val Leu Pro Asn Asn Ser Ile 
                725                 730                 735     


Thr Leu Asp Gly Ser Arg Ser Thr Asp Asp Gln Arg Ile Val Ser Tyr 
            740                 745                 750         


Leu Trp Ile Arg Asp Gly Gln Ser Pro Ala Ala Gly Asp Val Ile Asp 
        755                 760                 765             


Gly Ser Asp His Ser Val Ala Leu Gln Leu Thr Asn Leu Val Glu Gly 
    770                 775                 780                 


Val Tyr Thr Phe His Leu Arg Val Thr Asp Ser Gln Gly Ala Ser Asp 
785                 790                 795                 800 


Thr Asp Thr Ala Thr Val Glu Val Gln Pro Asp Pro Arg Lys Ser Gly 
                805                 810                 815     


Leu Val Glu Leu Thr Leu Gln Val Gly Val Gly Gln Leu Thr Glu Gln 
            820                 825                 830         


Arg Lys Asp Thr Leu Val Arg Gln Leu Ala Val Leu Leu Asn Val Leu 
        835                 840                 845             


Asp Ser Asp Ile Lys Val Gln Lys Ile Arg Ala His Ser Asp Leu Ser 
    850                 855                 860                 


Thr Val Ile Val Phe Tyr Val Gln Ser Arg Pro Pro Phe Lys Val Leu 
865                 870                 875                 880 


Lys Ala Ala Glu Val Ala Arg Asn Leu His Met Arg Leu Ser Lys Glu 
                885                 890                 895     


Lys Ala Asp Phe Leu Leu Phe Lys Val Leu Arg Val Asp Thr Ala Gly 
            900                 905                 910         


Cys Leu Leu Lys Cys Ser Gly His Gly His Cys Asp Pro Leu Thr Lys 
        915                 920                 925             


Arg Cys Ile Cys Ser His Leu Trp Met Glu Asn Leu Ile Gln Arg Tyr 
    930                 935                 940                 


Ile Trp Asp Gly Glu Ser Asn Cys Gly Ile Lys His Arg Ser Thr Glu 
945                 950                 955                 960 


His Asn Ser Ser Leu Met Val Ser Glu Ser Glu Phe Asp Ser Asp Gln 
                965                 970                 975     


Asp Thr Ile Phe Ser Arg Glu Lys Met Glu Arg Gly Asn Pro Lys Val 
            980                 985                 990         


Ser Met Asn Gly Ser Ile Arg Asn  Gly Ala Ser Phe Ser  Tyr Cys Ser 
        995                 1000                 1005             


Lys Asp  Arg 
    1010     


<210>  7446
<211>  1072
<212>  PRT
<213>  Homo Sapiens

<400>  7446

Met Ala Pro Pro Thr Gly Val Leu Ser Ser Leu Leu Leu Leu Val Thr 
1               5                   10                  15      


Ile Ala Gly Cys Ala Arg Lys Gln Cys Ser Glu Gly Arg Thr Tyr Ser 
            20                  25                  30          


Asn Ala Val Ile Ser Pro Asn Leu Glu Thr Thr Arg Ile Met Arg Val 
        35                  40                  45              


Ser His Thr Phe Pro Val Val Asp Cys Thr Ala Ala Cys Cys Asp Leu 
    50                  55                  60                  


Ser Ser Cys Asp Leu Ala Trp Trp Phe Glu Gly Arg Cys Tyr Leu Val 
65                  70                  75                  80  


Ser Cys Pro His Lys Glu Asn Cys Glu Pro Lys Lys Met Gly Pro Ile 
                85                  90                  95      


Arg Ser Tyr Leu Thr Phe Val Leu Arg Pro Val Gln Arg Pro Ala Gln 
            100                 105                 110         


Leu Leu Asp Tyr Gly Asp Met Met Leu Asn Arg Gly Ser Pro Ser Gly 
        115                 120                 125             


Ile Trp Gly Asp Ser Pro Glu Asp Ile Arg Lys Asp Leu Thr Phe Leu 
    130                 135                 140                 


Gly Lys Asp Trp Gly Leu Glu Glu Met Ser Glu Tyr Ser Asp Asp Tyr 
145                 150                 155                 160 


Arg Glu Leu Glu Lys Asp Leu Leu Gln Pro Ser Gly Lys Gln Glu Pro 
                165                 170                 175     


Arg Gly Ser Ala Glu Tyr Thr Asp Trp Gly Leu Leu Pro Gly Ser Glu 
            180                 185                 190         


Gly Ala Phe Asn Ser Ser Val Gly Asp Ser Pro Ala Val Pro Ala Glu 
        195                 200                 205             


Thr Gln Gln Asp Pro Glu Leu His Tyr Leu Asn Glu Ser Ala Ser Thr 
    210                 215                 220                 


Pro Ala Pro Lys Leu Pro Glu Arg Ser Val Leu Leu Pro Leu Pro Thr 
225                 230                 235                 240 


Thr Pro Ser Ser Gly Glu Val Leu Glu Lys Glu Lys Ala Ser Gln Leu 
                245                 250                 255     


Gln Glu Gln Ser Ser Asn Ser Ser Gly Lys Glu Val Leu Met Pro Ser 
            260                 265                 270         


His Ser Leu Pro Pro Ala Ser Leu Glu Leu Ser Ser Val Thr Val Glu 
        275                 280                 285             


Lys Ser Pro Val Leu Thr Val Thr Pro Gly Ser Thr Glu His Ser Ile 
    290                 295                 300                 


Pro Thr Pro Pro Thr Ser Ala Ala Pro Ser Glu Ser Thr Pro Ser Glu 
305                 310                 315                 320 


Leu Pro Ile Ser Pro Thr Thr Ala Pro Arg Thr Val Lys Glu Leu Thr 
                325                 330                 335     


Val Ser Ala Gly Asp Asn Leu Ile Ile Thr Leu Pro Asp Asn Glu Val 
            340                 345                 350         


Glu Leu Lys Ala Phe Val Ala Pro Ala Pro Pro Val Glu Thr Thr Tyr 
        355                 360                 365             


Asn Tyr Glu Trp Asn Leu Ile Ser His Pro Thr Asp Tyr Gln Gly Glu 
    370                 375                 380                 


Ile Lys Gln Gly His Lys Gln Thr Leu Asn Leu Ser Gln Leu Ser Val 
385                 390                 395                 400 


Gly Leu Tyr Val Phe Lys Val Thr Val Ser Ser Glu Asn Ala Phe Gly 
                405                 410                 415     


Glu Gly Phe Val Asn Val Thr Val Lys Pro Ala Arg Arg Val Asn Leu 
            420                 425                 430         


Pro Pro Val Ala Val Val Ser Pro Gln Leu Gln Glu Leu Thr Leu Pro 
        435                 440                 445             


Leu Thr Ser Ala Leu Ile Asp Gly Ser Gln Ser Thr Asp Asp Thr Glu 
    450                 455                 460                 


Ile Val Ser Tyr His Trp Glu Glu Ile Asn Gly Pro Phe Ile Glu Glu 
465                 470                 475                 480 


Lys Thr Ser Val Asp Ser Pro Val Leu Arg Leu Ser Asn Leu Asp Pro 
                485                 490                 495     


Gly Asn Tyr Ser Phe Arg Leu Thr Val Thr Asp Ser Asp Gly Ala Thr 
            500                 505                 510         


Asn Ser Thr Thr Ala Ala Leu Ile Val Asn Asn Ala Val Asp Tyr Pro 
        515                 520                 525             


Pro Val Ala Asn Ala Gly Pro Asn His Thr Ile Thr Leu Pro Gln Asn 
    530                 535                 540                 


Ser Ile Thr Leu Asn Gly Asn Gln Ser Ser Asp Asp His Gln Ile Val 
545                 550                 555                 560 


Leu Tyr Glu Trp Ser Leu Gly Pro Gly Ser Glu Gly Lys His Val Val 
                565                 570                 575     


Met Gln Gly Val Gln Thr Pro Tyr Leu His Leu Ser Ala Met Gln Glu 
            580                 585                 590         


Gly Asp Tyr Thr Phe Gln Leu Lys Val Thr Asp Ser Ser Arg Gln Gln 
        595                 600                 605             


Ser Thr Ala Val Val Thr Val Ile Val Gln Pro Glu Asn Asn Arg Pro 
    610                 615                 620                 


Pro Val Ala Val Ala Gly Pro Asp Lys Glu Leu Ile Phe Pro Val Glu 
625                 630                 635                 640 


Ser Ala Thr Leu Asp Gly Ser Ser Ser Ser Asp Asp His Gly Ile Val 
                645                 650                 655     


Phe Tyr His Trp Glu His Val Arg Gly Pro Ser Ala Val Glu Met Glu 
            660                 665                 670         


Asn Ile Asp Lys Ala Ile Ala Thr Val Thr Gly Leu Gln Val Gly Thr 
        675                 680                 685             


Tyr His Phe Arg Leu Thr Val Lys Asp Gln Gln Gly Leu Ser Ser Thr 
    690                 695                 700                 


Ser Thr Leu Thr Val Ala Val Lys Lys Glu Asn Asn Ser Pro Pro Arg 
705                 710                 715                 720 


Ala Arg Ala Gly Gly Arg His Val Leu Val Leu Pro Asn Asn Ser Ile 
                725                 730                 735     


Thr Leu Asp Gly Ser Arg Ser Thr Asp Asp Gln Arg Ile Val Ser Tyr 
            740                 745                 750         


Leu Trp Ile Arg Asp Gly Gln Ser Pro Ala Ala Gly Asp Val Ile Asp 
        755                 760                 765             


Gly Ser Asp His Ser Val Ala Leu Gln Leu Thr Asn Leu Val Glu Gly 
    770                 775                 780                 


Val Tyr Thr Phe His Leu Arg Val Thr Asp Ser Gln Gly Ala Ser Asp 
785                 790                 795                 800 


Thr Asp Thr Ala Thr Val Glu Val Gln Pro Asp Pro Arg Lys Ser Gly 
                805                 810                 815     


Leu Val Glu Leu Thr Leu Gln Val Gly Val Gly Gln Leu Thr Glu Gln 
            820                 825                 830         


Arg Lys Asp Thr Leu Val Arg Gln Leu Ala Val Leu Leu Asn Val Leu 
        835                 840                 845             


Asp Ser Asp Ile Lys Val Gln Lys Ile Arg Ala His Ser Asp Leu Ser 
    850                 855                 860                 


Thr Val Ile Val Phe Tyr Val Gln Ser Arg Pro Pro Phe Lys Val Leu 
865                 870                 875                 880 


Lys Ala Ala Glu Val Ala Arg Asn Leu His Met Arg Leu Ser Lys Glu 
                885                 890                 895     


Lys Ala Asp Phe Leu Leu Phe Lys Val Leu Arg Val Asp Thr Ala Gly 
            900                 905                 910         


Cys Leu Leu Lys Cys Ser Gly His Gly His Cys Asp Pro Leu Thr Lys 
        915                 920                 925             


Arg Cys Ile Cys Ser His Leu Trp Met Glu Asn Leu Ile Gln Arg Tyr 
    930                 935                 940                 


Ile Trp Asp Gly Glu Ser Asn Cys Glu Trp Ser Ile Phe Tyr Val Thr 
945                 950                 955                 960 


Val Leu Ala Phe Thr Leu Ile Val Leu Thr Gly Gly Phe Thr Trp Leu 
                965                 970                 975     


Cys Ile Cys Cys Cys Lys Arg Gln Lys Arg Thr Lys Ile Arg Lys Lys 
            980                 985                 990         


Thr Lys Tyr Thr Ile Leu Asp Asn  Met Asp Glu Gln Glu  Arg Met Glu 
        995                 1000                 1005             


Leu Arg  Pro Lys Tyr Gly Ile  Lys His Arg Ser Thr  Glu His Asn 
    1010                 1015                 1020             


Ser Ser  Leu Met Val Ser Glu  Ser Glu Phe Asp Ser  Asp Gln Asp 
    1025                 1030                 1035             


Thr Ile  Phe Ser Arg Glu Lys  Met Glu Arg Gly Asn  Pro Lys Val 
    1040                 1045                 1050             


Ser Met  Asn Gly Ser Ile Arg  Asn Gly Ala Ser Phe  Ser Tyr Cys 
    1055                 1060                 1065             


Ser Lys  Asp Arg 
    1070         


<210>  7447
<211>  483
<212>  PRT
<213>  Homo Sapiens

<400>  7447

Met Gln Glu Gly Asp Tyr Thr Phe Gln Leu Lys Val Thr Asp Ser Ser 
1               5                   10                  15      


Arg Gln Gln Ser Thr Ala Val Val Thr Val Ile Val Gln Pro Glu Asn 
            20                  25                  30          


Asn Arg Pro Pro Val Ala Val Ala Gly Pro Asp Lys Glu Leu Ile Phe 
        35                  40                  45              


Pro Val Glu Ser Ala Thr Leu Asp Gly Ser Ser Ser Ser Asp Asp His 
    50                  55                  60                  


Gly Ile Val Phe Tyr His Trp Glu His Val Arg Gly Pro Ser Ala Val 
65                  70                  75                  80  


Glu Met Glu Asn Ile Asp Lys Ala Ile Ala Thr Val Thr Gly Leu Gln 
                85                  90                  95      


Val Gly Thr Tyr His Phe Arg Leu Thr Val Lys Asp Gln Gln Gly Leu 
            100                 105                 110         


Ser Ser Thr Ser Thr Leu Thr Val Ala Val Lys Lys Glu Asn Asn Ser 
        115                 120                 125             


Pro Pro Arg Ala Arg Ala Gly Gly Arg His Val Leu Val Leu Pro Asn 
    130                 135                 140                 


Asn Ser Ile Thr Leu Asp Gly Ser Arg Ser Thr Asp Asp Gln Arg Ile 
145                 150                 155                 160 


Val Ser Tyr Leu Trp Ile Arg Asp Gly Gln Ser Pro Ala Ala Gly Asp 
                165                 170                 175     


Val Ile Asp Gly Ser Asp His Ser Val Ala Leu Gln Leu Thr Asn Leu 
            180                 185                 190         


Val Glu Gly Val Tyr Thr Phe His Leu Arg Val Thr Asp Ser Gln Gly 
        195                 200                 205             


Ala Ser Asp Thr Asp Thr Ala Thr Val Glu Val Gln Pro Asp Pro Arg 
    210                 215                 220                 


Lys Ser Gly Leu Val Glu Leu Thr Leu Gln Val Gly Val Gly Gln Leu 
225                 230                 235                 240 


Thr Glu Gln Arg Lys Asp Thr Leu Val Arg Gln Leu Ala Val Leu Leu 
                245                 250                 255     


Asn Val Leu Asp Ser Asp Ile Lys Val Gln Lys Ile Arg Ala His Ser 
            260                 265                 270         


Asp Leu Ser Thr Val Ile Val Phe Tyr Val Gln Ser Arg Pro Pro Phe 
        275                 280                 285             


Lys Val Leu Lys Ala Ala Glu Val Ala Arg Asn Leu His Met Arg Leu 
    290                 295                 300                 


Ser Lys Glu Lys Ala Asp Phe Leu Leu Phe Lys Val Leu Arg Val Asp 
305                 310                 315                 320 


Thr Ala Gly Cys Leu Leu Lys Cys Ser Gly His Gly His Cys Asp Pro 
                325                 330                 335     


Leu Thr Lys Arg Cys Ile Cys Ser His Leu Trp Met Glu Asn Leu Ile 
            340                 345                 350         


Gln Arg Tyr Ile Trp Asp Gly Glu Ser Asn Cys Glu Trp Ser Ile Phe 
        355                 360                 365             


Tyr Val Thr Val Leu Ala Phe Thr Leu Ile Val Leu Thr Gly Gly Phe 
    370                 375                 380                 


Thr Trp Leu Cys Ile Cys Cys Cys Lys Arg Gln Lys Arg Thr Lys Ile 
385                 390                 395                 400 


Arg Lys Lys Thr Lys Tyr Thr Ile Leu Asp Asn Met Asp Glu Gln Glu 
                405                 410                 415     


Arg Met Glu Leu Arg Pro Lys Tyr Gly Ile Lys His Arg Ser Thr Glu 
            420                 425                 430         


His Asn Ser Ser Leu Met Val Ser Glu Ser Glu Phe Asp Ser Asp Gln 
        435                 440                 445             


Asp Thr Ile Phe Ser Arg Glu Lys Met Glu Arg Gly Asn Pro Lys Val 
    450                 455                 460                 


Ser Met Asn Gly Ser Ile Arg Asn Gly Ala Ser Phe Ser Tyr Cys Ser 
465                 470                 475                 480 


Lys Asp Arg 
            


<210>  7448
<211>  1027
<212>  PRT
<213>  Homo Sapiens

<400>  7448

Met Arg Val Ser His Thr Phe Pro Val Val Asp Cys Thr Ala Ala Cys 
1               5                   10                  15      


Cys Asp Leu Ser Ser Cys Asp Leu Ala Trp Trp Phe Glu Gly Arg Cys 
            20                  25                  30          


Tyr Leu Val Ser Cys Pro His Lys Glu Asn Cys Glu Pro Lys Lys Met 
        35                  40                  45              


Gly Pro Ile Arg Ser Tyr Leu Thr Phe Val Leu Arg Pro Val Gln Arg 
    50                  55                  60                  


Pro Ala Gln Leu Leu Asp Tyr Gly Asp Met Met Leu Asn Arg Gly Ser 
65                  70                  75                  80  


Pro Ser Gly Ile Trp Gly Asp Ser Pro Glu Asp Ile Arg Lys Asp Leu 
                85                  90                  95      


Thr Phe Leu Gly Lys Asp Trp Gly Leu Glu Glu Met Ser Glu Tyr Ser 
            100                 105                 110         


Asp Asp Tyr Arg Glu Leu Glu Lys Asp Leu Leu Gln Pro Ser Gly Lys 
        115                 120                 125             


Gln Glu Pro Arg Gly Ser Ala Glu Tyr Thr Asp Trp Gly Leu Leu Pro 
    130                 135                 140                 


Gly Ser Glu Gly Ala Phe Asn Ser Ser Val Gly Asp Ser Pro Ala Val 
145                 150                 155                 160 


Pro Ala Glu Thr Gln Gln Asp Pro Glu Leu His Tyr Leu Asn Glu Ser 
                165                 170                 175     


Ala Ser Thr Pro Ala Pro Lys Leu Pro Glu Arg Ser Val Leu Leu Pro 
            180                 185                 190         


Leu Pro Thr Thr Pro Ser Ser Gly Glu Val Leu Glu Lys Glu Lys Ala 
        195                 200                 205             


Ser Gln Leu Gln Glu Gln Ser Ser Asn Ser Ser Gly Lys Glu Val Leu 
    210                 215                 220                 


Met Pro Ser His Ser Leu Pro Pro Ala Ser Leu Glu Leu Ser Ser Val 
225                 230                 235                 240 


Thr Val Glu Lys Ser Pro Val Leu Thr Val Thr Pro Gly Ser Thr Glu 
                245                 250                 255     


His Ser Ile Pro Thr Pro Pro Thr Ser Ala Ala Pro Ser Glu Ser Thr 
            260                 265                 270         


Pro Ser Glu Leu Pro Ile Ser Pro Thr Thr Ala Pro Arg Thr Val Lys 
        275                 280                 285             


Glu Leu Thr Val Ser Ala Gly Asp Asn Leu Ile Ile Thr Leu Pro Asp 
    290                 295                 300                 


Asn Glu Val Glu Leu Lys Ala Phe Val Ala Pro Ala Pro Pro Val Glu 
305                 310                 315                 320 


Thr Thr Tyr Asn Tyr Glu Trp Asn Leu Ile Ser His Pro Thr Asp Tyr 
                325                 330                 335     


Gln Gly Glu Ile Lys Gln Gly His Lys Gln Thr Leu Asn Leu Ser Gln 
            340                 345                 350         


Leu Ser Val Gly Leu Tyr Val Phe Lys Val Thr Val Ser Ser Glu Asn 
        355                 360                 365             


Ala Phe Gly Glu Gly Phe Val Asn Val Thr Val Lys Pro Ala Arg Arg 
    370                 375                 380                 


Val Asn Leu Pro Pro Val Ala Val Val Ser Pro Gln Leu Gln Glu Leu 
385                 390                 395                 400 


Thr Leu Pro Leu Thr Ser Ala Leu Ile Asp Gly Ser Gln Ser Thr Asp 
                405                 410                 415     


Asp Thr Glu Ile Val Ser Tyr His Trp Glu Glu Ile Asn Gly Pro Phe 
            420                 425                 430         


Ile Glu Glu Lys Thr Ser Val Asp Ser Pro Val Leu Arg Leu Ser Asn 
        435                 440                 445             


Leu Asp Pro Gly Asn Tyr Ser Phe Arg Leu Thr Val Thr Asp Ser Asp 
    450                 455                 460                 


Gly Ala Thr Asn Ser Thr Thr Ala Ala Leu Ile Val Asn Asn Ala Val 
465                 470                 475                 480 


Asp Tyr Pro Pro Val Ala Asn Ala Gly Pro Asn His Thr Ile Thr Leu 
                485                 490                 495     


Pro Gln Asn Ser Ile Thr Leu Asn Gly Asn Gln Ser Ser Asp Asp His 
            500                 505                 510         


Gln Ile Val Leu Tyr Glu Trp Ser Leu Gly Pro Gly Ser Glu Gly Lys 
        515                 520                 525             


His Val Val Met Gln Gly Val Gln Thr Pro Tyr Leu His Leu Ser Ala 
    530                 535                 540                 


Met Gln Glu Gly Asp Tyr Thr Phe Gln Leu Lys Val Thr Asp Ser Ser 
545                 550                 555                 560 


Arg Gln Gln Ser Thr Ala Val Val Thr Val Ile Val Gln Pro Glu Asn 
                565                 570                 575     


Asn Arg Pro Pro Val Ala Val Ala Gly Pro Asp Lys Glu Leu Ile Phe 
            580                 585                 590         


Pro Val Glu Ser Ala Thr Leu Asp Gly Ser Ser Ser Ser Asp Asp His 
        595                 600                 605             


Gly Ile Val Phe Tyr His Trp Glu His Val Arg Gly Pro Ser Ala Val 
    610                 615                 620                 


Glu Met Glu Asn Ile Asp Lys Ala Ile Ala Thr Val Thr Gly Leu Gln 
625                 630                 635                 640 


Val Gly Thr Tyr His Phe Arg Leu Thr Val Lys Asp Gln Gln Gly Leu 
                645                 650                 655     


Ser Ser Thr Ser Thr Leu Thr Val Ala Val Lys Lys Glu Asn Asn Ser 
            660                 665                 670         


Pro Pro Arg Ala Arg Ala Gly Gly Arg His Val Leu Val Leu Pro Asn 
        675                 680                 685             


Asn Ser Ile Thr Leu Asp Gly Ser Arg Ser Thr Asp Asp Gln Arg Ile 
    690                 695                 700                 


Val Ser Tyr Leu Trp Ile Arg Asp Gly Gln Ser Pro Ala Ala Gly Asp 
705                 710                 715                 720 


Val Ile Asp Gly Ser Asp His Ser Val Ala Leu Gln Leu Thr Asn Leu 
                725                 730                 735     


Val Glu Gly Val Tyr Thr Phe His Leu Arg Val Thr Asp Ser Gln Gly 
            740                 745                 750         


Ala Ser Asp Thr Asp Thr Ala Thr Val Glu Val Gln Pro Asp Pro Arg 
        755                 760                 765             


Lys Ser Gly Leu Val Glu Leu Thr Leu Gln Val Gly Val Gly Gln Leu 
    770                 775                 780                 


Thr Glu Gln Arg Lys Asp Thr Leu Val Arg Gln Leu Ala Val Leu Leu 
785                 790                 795                 800 


Asn Val Leu Asp Ser Asp Ile Lys Val Gln Lys Ile Arg Ala His Ser 
                805                 810                 815     


Asp Leu Ser Thr Val Ile Val Phe Tyr Val Gln Ser Arg Pro Pro Phe 
            820                 825                 830         


Lys Val Leu Lys Ala Ala Glu Val Ala Arg Asn Leu His Met Arg Leu 
        835                 840                 845             


Ser Lys Glu Lys Ala Asp Phe Leu Leu Phe Lys Val Leu Arg Val Asp 
    850                 855                 860                 


Thr Ala Gly Cys Leu Leu Lys Cys Ser Gly His Gly His Cys Asp Pro 
865                 870                 875                 880 


Leu Thr Lys Arg Cys Ile Cys Ser His Leu Trp Met Glu Asn Leu Ile 
                885                 890                 895     


Gln Arg Tyr Ile Trp Asp Gly Glu Ser Asn Cys Glu Trp Ser Ile Phe 
            900                 905                 910         


Tyr Val Thr Val Leu Ala Phe Thr Leu Ile Val Leu Thr Gly Gly Phe 
        915                 920                 925             


Thr Trp Leu Cys Ile Cys Cys Cys Lys Arg Gln Lys Arg Thr Lys Ile 
    930                 935                 940                 


Arg Lys Lys Thr Lys Tyr Thr Ile Leu Asp Asn Met Asp Glu Gln Glu 
945                 950                 955                 960 


Arg Met Glu Leu Arg Pro Lys Tyr Gly Ile Lys His Arg Ser Thr Glu 
                965                 970                 975     


His Asn Ser Ser Leu Met Val Ser Glu Ser Glu Phe Asp Ser Asp Gln 
            980                 985                 990         


Asp Thr Ile Phe Ser Arg Glu Lys  Met Glu Arg Gly Asn  Pro Lys Val 
        995                 1000                 1005             


Ser Met  Asn Gly Ser Ile Arg  Asn Gly Ala Ser Phe  Ser Tyr Cys 
    1010                 1015                 1020             


Ser Lys  Asp Arg 
    1025         


<210>  7449
<211>  1063
<212>  PRT
<213>  Homo Sapiens

<400>  7449

Met Thr Arg Leu Gly Trp Pro Ser Pro Cys Cys Ala Arg Lys Gln Cys 
1               5                   10                  15      


Ser Glu Gly Arg Thr Tyr Ser Asn Ala Val Ile Ser Pro Asn Leu Glu 
            20                  25                  30          


Thr Thr Arg Ile Met Arg Val Ser His Thr Phe Pro Val Val Asp Cys 
        35                  40                  45              


Thr Ala Ala Cys Cys Asp Leu Ser Ser Cys Asp Leu Ala Trp Trp Phe 
    50                  55                  60                  


Glu Gly Arg Cys Tyr Leu Val Ser Cys Pro His Lys Glu Asn Cys Glu 
65                  70                  75                  80  


Pro Lys Lys Met Gly Pro Ile Arg Ser Tyr Leu Thr Phe Val Leu Arg 
                85                  90                  95      


Pro Val Gln Arg Pro Ala Gln Leu Leu Asp Tyr Gly Asp Met Met Leu 
            100                 105                 110         


Asn Arg Gly Ser Pro Ser Gly Ile Trp Gly Asp Ser Pro Glu Asp Ile 
        115                 120                 125             


Arg Lys Asp Leu Thr Phe Leu Gly Lys Asp Trp Gly Leu Glu Glu Met 
    130                 135                 140                 


Ser Glu Tyr Ser Asp Asp Tyr Arg Glu Leu Glu Lys Asp Leu Leu Gln 
145                 150                 155                 160 


Pro Ser Gly Lys Gln Glu Pro Arg Gly Ser Ala Glu Tyr Thr Asp Trp 
                165                 170                 175     


Gly Leu Leu Pro Gly Ser Glu Gly Ala Phe Asn Ser Ser Val Gly Asp 
            180                 185                 190         


Ser Pro Ala Val Pro Ala Glu Thr Gln Gln Asp Pro Glu Leu His Tyr 
        195                 200                 205             


Leu Asn Glu Ser Ala Ser Thr Pro Ala Pro Lys Leu Pro Glu Arg Ser 
    210                 215                 220                 


Val Leu Leu Pro Leu Pro Thr Thr Pro Ser Ser Gly Glu Val Leu Glu 
225                 230                 235                 240 


Lys Glu Lys Ala Ser Gln Leu Gln Glu Gln Ser Ser Asn Ser Ser Gly 
                245                 250                 255     


Lys Glu Val Leu Met Pro Ser His Ser Leu Pro Pro Ala Ser Leu Glu 
            260                 265                 270         


Leu Ser Ser Val Thr Val Glu Lys Ser Pro Val Leu Thr Val Thr Pro 
        275                 280                 285             


Gly Ser Thr Glu His Ser Ile Pro Thr Pro Pro Thr Ser Ala Ala Pro 
    290                 295                 300                 


Ser Glu Ser Thr Pro Ser Glu Leu Pro Ile Ser Pro Thr Thr Ala Pro 
305                 310                 315                 320 


Arg Thr Val Lys Glu Leu Thr Val Ser Ala Gly Asp Asn Leu Ile Ile 
                325                 330                 335     


Thr Leu Pro Asp Asn Glu Val Glu Leu Lys Ala Phe Val Ala Pro Ala 
            340                 345                 350         


Pro Pro Val Glu Thr Thr Tyr Asn Tyr Glu Trp Asn Leu Ile Ser His 
        355                 360                 365             


Pro Thr Asp Tyr Gln Gly Glu Ile Lys Gln Gly His Lys Gln Thr Leu 
    370                 375                 380                 


Asn Leu Ser Gln Leu Ser Val Gly Leu Tyr Val Phe Lys Val Thr Val 
385                 390                 395                 400 


Ser Ser Glu Asn Ala Phe Gly Glu Gly Phe Val Asn Val Thr Val Lys 
                405                 410                 415     


Pro Ala Arg Arg Val Asn Leu Pro Pro Val Ala Val Val Ser Pro Gln 
            420                 425                 430         


Leu Gln Glu Leu Thr Leu Pro Leu Thr Ser Ala Leu Ile Asp Gly Ser 
        435                 440                 445             


Gln Ser Thr Asp Asp Thr Glu Ile Val Ser Tyr His Trp Glu Glu Ile 
    450                 455                 460                 


Asn Gly Pro Phe Ile Glu Glu Lys Thr Ser Val Asp Ser Pro Val Leu 
465                 470                 475                 480 


Arg Leu Ser Asn Leu Asp Pro Gly Asn Tyr Ser Phe Arg Leu Thr Val 
                485                 490                 495     


Thr Asp Ser Asp Gly Ala Thr Asn Ser Thr Thr Ala Ala Leu Ile Val 
            500                 505                 510         


Asn Asn Ala Val Asp Tyr Pro Pro Val Ala Asn Ala Gly Pro Asn His 
        515                 520                 525             


Thr Ile Thr Leu Pro Gln Asn Ser Ile Thr Leu Asn Gly Asn Gln Ser 
    530                 535                 540                 


Ser Asp Asp His Gln Ile Val Leu Tyr Glu Trp Ser Leu Gly Pro Gly 
545                 550                 555                 560 


Ser Glu Gly Lys His Val Val Met Gln Gly Val Gln Thr Pro Tyr Leu 
                565                 570                 575     


His Leu Ser Ala Met Gln Glu Gly Asp Tyr Thr Phe Gln Leu Lys Val 
            580                 585                 590         


Thr Asp Ser Ser Arg Gln Gln Ser Thr Ala Val Val Thr Val Ile Val 
        595                 600                 605             


Gln Pro Glu Asn Asn Arg Pro Pro Val Ala Val Ala Gly Pro Asp Lys 
    610                 615                 620                 


Glu Leu Ile Phe Pro Val Glu Ser Ala Thr Leu Asp Gly Ser Ser Ser 
625                 630                 635                 640 


Ser Asp Asp His Gly Ile Val Phe Tyr His Trp Glu His Val Arg Gly 
                645                 650                 655     


Pro Ser Ala Val Glu Met Glu Asn Ile Asp Lys Ala Ile Ala Thr Val 
            660                 665                 670         


Thr Gly Leu Gln Val Gly Thr Tyr His Phe Arg Leu Thr Val Lys Asp 
        675                 680                 685             


Gln Gln Gly Leu Ser Ser Thr Ser Thr Leu Thr Val Ala Val Lys Lys 
    690                 695                 700                 


Glu Asn Asn Ser Pro Pro Arg Ala Arg Ala Gly Gly Arg His Val Leu 
705                 710                 715                 720 


Val Leu Pro Asn Asn Ser Ile Thr Leu Asp Gly Ser Arg Ser Thr Asp 
                725                 730                 735     


Asp Gln Arg Ile Val Ser Tyr Leu Trp Ile Arg Asp Gly Gln Ser Pro 
            740                 745                 750         


Ala Ala Gly Asp Val Ile Asp Gly Ser Asp His Ser Val Ala Leu Gln 
        755                 760                 765             


Leu Thr Asn Leu Val Glu Gly Val Tyr Thr Phe His Leu Arg Val Thr 
    770                 775                 780                 


Asp Ser Gln Gly Ala Ser Asp Thr Asp Thr Ala Thr Val Glu Val Gln 
785                 790                 795                 800 


Pro Asp Pro Arg Lys Ser Gly Leu Val Glu Leu Thr Leu Gln Val Gly 
                805                 810                 815     


Val Gly Gln Leu Thr Glu Gln Arg Lys Asp Thr Leu Val Arg Gln Leu 
            820                 825                 830         


Ala Val Leu Leu Asn Val Leu Asp Ser Asp Ile Lys Val Gln Lys Ile 
        835                 840                 845             


Arg Ala His Ser Asp Leu Ser Thr Val Ile Val Phe Tyr Val Gln Ser 
    850                 855                 860                 


Arg Pro Pro Phe Lys Val Leu Lys Ala Ala Glu Val Ala Arg Asn Leu 
865                 870                 875                 880 


His Met Arg Leu Ser Lys Glu Lys Ala Asp Phe Leu Leu Phe Lys Val 
                885                 890                 895     


Leu Arg Val Asp Thr Ala Gly Cys Leu Leu Lys Cys Ser Gly His Gly 
            900                 905                 910         


His Cys Asp Pro Leu Thr Lys Arg Cys Ile Cys Ser His Leu Trp Met 
        915                 920                 925             


Glu Asn Leu Ile Gln Arg Tyr Ile Trp Asp Gly Glu Ser Asn Cys Glu 
    930                 935                 940                 


Trp Ser Ile Phe Tyr Val Thr Val Leu Ala Phe Thr Leu Ile Val Leu 
945                 950                 955                 960 


Thr Gly Gly Phe Thr Trp Leu Cys Ile Cys Cys Cys Lys Arg Gln Lys 
                965                 970                 975     


Arg Thr Lys Ile Arg Lys Lys Thr Lys Tyr Thr Ile Leu Asp Asn Met 
            980                 985                 990         


Asp Glu Gln Glu Arg Met Glu Leu  Arg Pro Lys Tyr Gly  Ile Lys His 
        995                 1000                 1005             


Arg Ser  Thr Glu His Asn Ser  Ser Leu Met Val Ser  Glu Ser Glu 
    1010                 1015                 1020             


Phe Asp  Ser Asp Gln Asp Thr  Ile Phe Ser Arg Glu  Lys Met Glu 
    1025                 1030                 1035             


Arg Gly  Asn Pro Lys Val Ser  Met Asn Gly Ser Ile  Arg Asn Gly 
    1040                 1045                 1050             


Ala Ser  Phe Ser Tyr Cys Ser  Lys Asp Arg 
    1055                 1060             


<210>  7450
<211>  82
<212>  PRT
<213>  Homo Sapiens

<400>  7450

Ile Leu Leu Thr Val Leu Thr Cys Tyr Phe Trp Lys Lys Asn Gln Lys 
1               5                   10                  15      


Leu Glu Tyr Lys Tyr Ser Lys Leu Val Met Asn Ala Thr Leu Lys Asp 
            20                  25                  30          


Cys Asp Leu Pro Ala Ala Asp Ser Cys Ala Ile Met Glu Gly Glu Asp 
        35                  40                  45              


Val Glu Asp Asp Leu Ile Phe Thr Ser Lys Lys Ser Leu Phe Gly Lys 
    50                  55                  60                  


Ile Lys Ser Phe Thr Ser Lys Val Ser Gly Ser Ser Pro Leu Gly Ala 
65                  70                  75                  80  


Glu Ser 
        


<210>  7451
<211>  62
<212>  PRT
<213>  Homo Sapiens

<400>  7451

Met Ala Glu Pro Gly His Ser His His Leu Ser Ala Arg Val Arg Gly 
1               5                   10                  15      


Arg Thr Glu Arg Arg Ile Pro Arg Leu Trp Arg Leu Leu Leu Trp Ala 
            20                  25                  30          


Gly Thr Ala Phe Gln Val Thr Gln Gly Thr Gly Pro Glu Leu His Ala 
        35                  40                  45              


Cys Lys Glu Pro Ser Pro Ala Thr Pro Gly Ser Phe Trp Ile 
    50                  55                  60          


<210>  7452
<211>  91
<212>  PRT
<213>  Homo Sapiens

<400>  7452

Met Ala Glu Pro Gly His Ser His His Leu Ser Ala Arg Val Arg Gly 
1               5                   10                  15      


Arg Thr Glu Arg Arg Ile Pro Arg Leu Trp Arg Leu Leu Leu Trp Ala 
            20                  25                  30          


Gly Thr Ala Phe Gln Val Thr Gln Gly Thr Gly Pro Glu Leu His Ala 
        35                  40                  45              


Cys Lys Glu Ser Glu Tyr His Tyr Glu Tyr Thr Ala Cys Asp Ser Thr 
    50                  55                  60                  


Gly Ser Arg Trp Arg Val Ala Val Pro His Thr Pro Gly Leu Cys Thr 
65                  70                  75                  80  


Ser Leu Pro Asp Pro Ile Lys Gly Thr Glu Cys 
                85                  90      


<210>  7453
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  7453

Met Ala Glu Pro Gly His Ser His His Leu Ser Ala Arg Val Arg Gly 
1               5                   10                  15      


Arg Thr Glu Arg Arg Ile Pro Arg Leu Trp Arg Leu Leu Leu Trp Ala 
            20                  25                  30          


Gly Thr Ala Phe Gln Val Thr Gln Gly Thr Gly Pro Glu Leu His Ala 
        35                  40                  45              


Cys Lys Glu Ser Glu Tyr His Tyr Glu Tyr Thr Ala Cys Asp Ser Thr 
    50                  55                  60                  


Gly Ser Arg Trp Arg Val Ala Val Pro His Thr Pro Gly Leu Cys Thr 
65                  70                  75                  80  


Ser Leu Pro Asp Pro Ile Lys Gly Thr Glu Cys Ser Phe Ser Cys Asn 
                85                  90                  95      


Ala Gly Glu Phe Leu Asp Met Lys Asp Gln Ser Cys Lys Pro Cys Ala 
            100                 105                 110         


Glu Gly Arg Tyr Ser Leu Gly Thr Gly Ile Arg Phe Asp Glu Trp Asp 
        115                 120                 125             


Glu Leu Pro His Gly Phe Ala Ser Leu Ser Ala Asn Met Glu Leu Asp 
    130                 135                 140                 


Asp Ser Ala Ala Glu Ser Thr Gly 
145                 150         


<210>  7454
<211>  156
<212>  PRT
<213>  Homo Sapiens

<400>  7454

Met Ala Glu Pro Gly His Ser His His Leu Ser Ala Arg Val Arg Gly 
1               5                   10                  15      


Arg Thr Glu Arg Arg Ile Pro Arg Leu Trp Arg Leu Leu Leu Trp Ala 
            20                  25                  30          


Gly Thr Ala Phe Gln Val Thr Gln Gly Thr Gly Pro Glu Leu His Ala 
        35                  40                  45              


Cys Lys Glu Ser Glu Tyr His Tyr Glu Tyr Thr Ala Cys Asp Ser Thr 
    50                  55                  60                  


Gly Ser Arg Trp Arg Val Ala Val Pro His Thr Pro Gly Leu Cys Thr 
65                  70                  75                  80  


Ser Leu Pro Asp Pro Ile Lys Gly Thr Glu Cys Ser Phe Ser Cys Asn 
                85                  90                  95      


Ala Gly Glu Phe Leu Asp Met Lys Asp Gln Ser Cys Lys Pro Cys Ala 
            100                 105                 110         


Glu Gly Arg Tyr Ser Leu Gly Thr Gly Ile Arg Phe Asp Glu Trp Asp 
        115                 120                 125             


Glu Leu Pro His Gly Phe Ala Ser Leu Ser Ala Asn Met Glu Leu Asp 
    130                 135                 140                 


Asp Ser Ala Ala Glu Ser Thr Gly Asn Cys Thr Ser 
145                 150                 155     


<210>  7455
<211>  205
<212>  PRT
<213>  Homo Sapiens

<400>  7455

Met Ala Glu Pro Gly His Ser His His Leu Ser Ala Arg Val Arg Gly 
1               5                   10                  15      


Arg Thr Glu Arg Arg Ile Pro Arg Leu Trp Arg Leu Leu Leu Trp Ala 
            20                  25                  30          


Gly Thr Ala Phe Gln Val Thr Gln Gly Thr Gly Pro Glu Leu His Ala 
        35                  40                  45              


Cys Lys Glu Ser Glu Tyr His Tyr Glu Tyr Thr Ala Cys Asp Ser Thr 
    50                  55                  60                  


Gly Ser Arg Trp Arg Val Ala Val Pro His Thr Pro Gly Leu Cys Thr 
65                  70                  75                  80  


Ser Leu Pro Asp Pro Ile Lys Gly Thr Glu Cys Ser Phe Ser Cys Asn 
                85                  90                  95      


Ala Gly Glu Phe Leu Asp Met Lys Asp Gln Ser Cys Lys Pro Cys Ala 
            100                 105                 110         


Glu Gly Arg Tyr Ser Leu Gly Thr Gly Ile Arg Phe Asp Glu Trp Asp 
        115                 120                 125             


Glu Leu Pro His Gly Phe Ala Ser Leu Ser Ala Asn Met Glu Leu Asp 
    130                 135                 140                 


Asp Ser Ala Ala Glu Ser Thr Gly Asn Cys Thr Ser Ser Lys Trp Val 
145                 150                 155                 160 


Pro Arg Gly Asp Tyr Ile Ala Ser Asn Thr Asp Glu Cys Thr Ala Thr 
                165                 170                 175     


Leu Met Tyr Ala Val Asn Leu Lys Gln Ser Gly Thr Val Asn Phe Glu 
            180                 185                 190         


Tyr Tyr Tyr Pro Asp Ser Ser Ile Ile Phe Glu Phe Phe 
        195                 200                 205 


<210>  7456
<211>  1013
<212>  PRT
<213>  Homo Sapiens

<400>  7456

Met Ala Glu Pro Gly His Ser His His Leu Ser Ala Arg Val Arg Gly 
1               5                   10                  15      


Arg Thr Glu Arg Arg Ile Pro Arg Leu Trp Arg Leu Leu Leu Trp Ala 
            20                  25                  30          


Gly Thr Ala Phe Gln Val Thr Gln Gly Thr Gly Pro Glu Leu His Ala 
        35                  40                  45              


Cys Lys Glu Ser Glu Tyr His Tyr Glu Tyr Thr Ala Cys Asp Ser Thr 
    50                  55                  60                  


Gly Ser Arg Trp Arg Val Ala Val Pro His Thr Pro Gly Leu Cys Thr 
65                  70                  75                  80  


Ser Leu Pro Asp Pro Ile Lys Gly Thr Glu Cys Ser Phe Ser Cys Asn 
                85                  90                  95      


Ala Gly Glu Phe Leu Asp Met Lys Asp Gln Ser Cys Lys Pro Cys Ala 
            100                 105                 110         


Glu Gly Arg Tyr Ser Leu Gly Thr Gly Ile Arg Phe Asp Glu Trp Asp 
        115                 120                 125             


Glu Leu Pro His Gly Phe Ala Ser Leu Ser Ala Asn Met Glu Leu Asp 
    130                 135                 140                 


Asp Ser Ala Ala Glu Ser Thr Gly Asn Cys Thr Ser Ser Lys Trp Val 
145                 150                 155                 160 


Pro Arg Gly Asp Tyr Ile Ala Ser Asn Thr Asp Glu Cys Thr Ala Thr 
                165                 170                 175     


Leu Met Tyr Ala Val Asn Leu Lys Gln Ser Gly Thr Val Asn Phe Glu 
            180                 185                 190         


Tyr Tyr Tyr Pro Asp Ser Ser Ile Ile Phe Glu Phe Phe Val Gln Asn 
        195                 200                 205             


Asp Gln Cys Gln Pro Asn Ala Asp Asp Ser Arg Trp Met Lys Thr Thr 
    210                 215                 220                 


Glu Lys Gly Trp Glu Phe His Ser Val Glu Leu Asn Arg Gly Asn Asn 
225                 230                 235                 240 


Val Leu Tyr Trp Arg Thr Thr Ala Phe Ser Val Trp Thr Lys Val Pro 
                245                 250                 255     


Lys Pro Val Leu Val Arg Asn Ile Ala Ile Thr Gly Val Ala Tyr Thr 
            260                 265                 270         


Ser Glu Cys Phe Pro Cys Lys Pro Gly Thr Tyr Ala Asp Lys Gln Gly 
        275                 280                 285             


Ser Ser Phe Cys Lys Leu Cys Pro Ala Asn Ser Tyr Ser Asn Lys Gly 
    290                 295                 300                 


Glu Thr Ser Cys His Gln Cys Asp Pro Asp Lys Tyr Ser Glu Lys Gly 
305                 310                 315                 320 


Ser Ser Ser Cys Asn Val Arg Pro Ala Cys Thr Asp Lys Asp Tyr Phe 
                325                 330                 335     


Tyr Thr His Thr Ala Cys Asp Ala Asn Gly Glu Thr Gln Leu Met Tyr 
            340                 345                 350         


Lys Trp Ala Lys Pro Lys Ile Cys Ser Glu Asp Leu Glu Gly Ala Val 
        355                 360                 365             


Lys Leu Pro Ala Ser Gly Val Lys Thr His Cys Pro Pro Cys Asn Pro 
    370                 375                 380                 


Gly Phe Phe Lys Thr Asn Asn Ser Thr Cys Gln Pro Cys Pro Tyr Gly 
385                 390                 395                 400 


Ser Tyr Ser Asn Gly Ser Asp Cys Thr Arg Cys Pro Ala Gly Thr Glu 
                405                 410                 415     


Pro Ala Val Gly Phe Glu Tyr Lys Trp Trp Asn Thr Leu Pro Thr Asn 
            420                 425                 430         


Met Glu Thr Thr Val Leu Ser Gly Ile Asn Phe Glu Tyr Lys Gly Met 
        435                 440                 445             


Thr Gly Trp Glu Val Ala Gly Asp His Ile Tyr Thr Ala Ala Gly Ala 
    450                 455                 460                 


Ser Asp Asn Asp Phe Met Ile Leu Thr Leu Val Val Pro Gly Phe Arg 
465                 470                 475                 480 


Pro Pro Gln Ser Val Met Ala Asp Thr Glu Asn Lys Glu Val Ala Arg 
                485                 490                 495     


Ile Thr Phe Val Phe Glu Thr Leu Cys Ser Val Asn Cys Glu Leu Tyr 
            500                 505                 510         


Phe Met Val Gly Val Asn Ser Arg Thr Asn Thr Pro Val Glu Thr Trp 
        515                 520                 525             


Lys Gly Ser Lys Gly Lys Gln Ser Tyr Thr Tyr Ile Ile Glu Glu Asn 
    530                 535                 540                 


Thr Thr Thr Ser Phe Thr Trp Ala Phe Gln Arg Thr Thr Phe His Glu 
545                 550                 555                 560 


Ala Ser Arg Lys Tyr Thr Asn Asp Val Ala Lys Ile Tyr Ser Ile Asn 
                565                 570                 575     


Val Thr Asn Val Met Asn Gly Val Ala Ser Tyr Cys Arg Pro Cys Ala 
            580                 585                 590         


Leu Glu Ala Ser Asp Val Gly Ser Ser Cys Thr Ser Cys Pro Ala Gly 
        595                 600                 605             


Tyr Tyr Ile Asp Arg Asp Ser Gly Thr Cys His Ser Cys Pro Thr Asn 
    610                 615                 620                 


Thr Ile Leu Lys Ala His Gln Pro Tyr Gly Val Gln Ala Cys Val Pro 
625                 630                 635                 640 


Cys Gly Pro Gly Thr Lys Asn Asn Lys Ile His Ser Leu Cys Tyr Asn 
                645                 650                 655     


Asp Cys Thr Phe Ser Arg Asn Thr Pro Thr Arg Thr Phe Asn Tyr Asn 
            660                 665                 670         


Phe Ser Ala Leu Ala Asn Thr Val Thr Leu Ala Gly Gly Pro Ser Phe 
        675                 680                 685             


Thr Ser Lys Gly Leu Lys Tyr Phe His His Phe Thr Leu Ser Leu Cys 
    690                 695                 700                 


Gly Asn Gln Gly Arg Lys Met Ser Val Cys Thr Asp Asn Val Thr Asp 
705                 710                 715                 720 


Leu Arg Ile Pro Glu Gly Glu Ser Gly Phe Ser Lys Ser Ile Thr Ala 
                725                 730                 735     


Tyr Val Cys Gln Ala Val Ile Ile Pro Pro Glu Val Thr Gly Tyr Lys 
            740                 745                 750         


Ala Gly Val Ser Ser Gln Pro Val Ser Leu Ala Asp Arg Leu Ile Gly 
        755                 760                 765             


Val Thr Thr Asp Met Thr Leu Asp Gly Ile Thr Ser Pro Ala Glu Leu 
    770                 775                 780                 


Phe His Leu Glu Ser Leu Gly Ile Pro Asp Val Ile Phe Phe Tyr Arg 
785                 790                 795                 800 


Ser Asn Asp Val Thr Gln Ser Cys Ser Ser Gly Arg Ser Thr Thr Ile 
                805                 810                 815     


Arg Val Arg Cys Ser Pro Gln Lys Thr Val Pro Gly Ser Leu Leu Leu 
            820                 825                 830         


Pro Gly Thr Cys Ser Asp Gly Thr Cys Asp Gly Cys Asn Phe His Phe 
        835                 840                 845             


Leu Trp Glu Ser Ala Ala Ala Cys Pro Leu Cys Ser Val Ala Asp Tyr 
    850                 855                 860                 


His Ala Ile Val Ser Ser Cys Val Ala Gly Ile Gln Lys Thr Thr Tyr 
865                 870                 875                 880 


Val Trp Arg Glu Pro Lys Leu Cys Ser Gly Gly Ile Ser Leu Pro Glu 
                885                 890                 895     


Gln Arg Val Thr Ile Cys Lys Thr Ile Asp Phe Trp Leu Lys Val Gly 
            900                 905                 910         


Ile Ser Ala Gly Thr Cys Thr Ala Ile Leu Leu Thr Val Leu Thr Cys 
        915                 920                 925             


Tyr Phe Trp Lys Lys Asn Gln Lys Leu Glu Tyr Lys Tyr Ser Lys Leu 
    930                 935                 940                 


Val Met Asn Ala Thr Leu Lys Asp Cys Asp Leu Pro Ala Ala Asp Ser 
945                 950                 955                 960 


Cys Ala Ile Met Glu Gly Glu Asp Val Glu Asp Asp Leu Ile Phe Thr 
                965                 970                 975     


Ser Lys Lys Ser Leu Phe Gly Lys Ile Lys Ser Phe Thr Ser Lys Arg 
            980                 985                 990         


Thr Pro Asp Gly Phe Asp Ser Val  Pro Leu Lys Thr Ser  Ser Gly Gly 
        995                 1000                 1005             


Leu Asp  Met Asp Leu 
    1010             


<210>  7457
<211>  901
<212>  PRT
<213>  Homo Sapiens

<400>  7457

Met Ala Glu Pro Gly His Ser His His Leu Ser Ala Arg Val Arg Gly 
1               5                   10                  15      


Arg Thr Glu Arg Arg Ile Pro Arg Leu Trp Arg Leu Leu Leu Trp Ala 
            20                  25                  30          


Gly Thr Ala Phe Gln Val Thr Gln Gly Thr Gly Pro Glu Leu His Ala 
        35                  40                  45              


Cys Lys Glu Ser Glu Tyr His Tyr Glu Tyr Thr Ala Cys Asp Ser Thr 
    50                  55                  60                  


Gly Ser Arg Trp Arg Val Ala Val Pro His Thr Pro Gly Leu Cys Thr 
65                  70                  75                  80  


Ser Leu Pro Asp Pro Ile Lys Gly Thr Glu Cys Ser Phe Ser Cys Asn 
                85                  90                  95      


Ala Gly Glu Phe Leu Asp Met Lys Asp Gln Ser Cys Lys Pro Cys Ala 
            100                 105                 110         


Glu Gly Arg Tyr Ser Leu Gly Thr Gly Ile Arg Phe Asp Glu Trp Asp 
        115                 120                 125             


Glu Leu Pro His Gly Phe Ala Ser Leu Ser Ala Asn Met Glu Leu Asp 
    130                 135                 140                 


Asp Ser Ala Ala Glu Ser Thr Gly Asn Cys Thr Ser Ser Lys Trp Val 
145                 150                 155                 160 


Pro Arg Gly Asp Tyr Ile Ala Ser Asn Thr Asp Glu Cys Thr Ala Thr 
                165                 170                 175     


Leu Met Tyr Ala Val Asn Leu Lys Gln Ser Gly Thr Val Asn Phe Glu 
            180                 185                 190         


Tyr Tyr Tyr Pro Asp Ser Ser Ile Ile Phe Glu Phe Phe Val Gln Asn 
        195                 200                 205             


Asp Gln Cys Gln Pro Asn Ala Asp Asp Ser Arg Trp Met Lys Thr Thr 
    210                 215                 220                 


Glu Lys Gly Trp Glu Phe His Ser Val Glu Leu Asn Arg Gly Asn Asn 
225                 230                 235                 240 


Val Leu Tyr Trp Arg Thr Thr Ala Phe Ser Val Trp Thr Lys Val Pro 
                245                 250                 255     


Lys Pro Val Leu Val Arg Asn Ile Ala Ile Thr Glu Lys Gly Ser Ser 
            260                 265                 270         


Ser Cys Asn Val Arg Pro Ala Cys Thr Asp Lys Asp Tyr Phe Tyr Thr 
        275                 280                 285             


His Thr Ala Cys Asp Ala Asn Gly Glu Thr Gln Leu Met Tyr Lys Trp 
    290                 295                 300                 


Ala Lys Pro Lys Ile Cys Ser Glu Asp Leu Glu Gly Ala Val Lys Leu 
305                 310                 315                 320 


Pro Ala Ser Gly Val Lys Thr His Cys Pro Pro Cys Asn Pro Gly Phe 
                325                 330                 335     


Phe Lys Thr Asn Asn Ser Thr Cys Gln Pro Cys Pro Tyr Gly Ser Tyr 
            340                 345                 350         


Ser Asn Gly Ser Asp Cys Thr Arg Cys Pro Ala Gly Thr Glu Pro Ala 
        355                 360                 365             


Val Gly Phe Glu Tyr Lys Trp Trp Asn Thr Leu Pro Thr Asn Met Glu 
    370                 375                 380                 


Thr Thr Val Leu Ser Gly Ile Asn Phe Glu Tyr Lys Gly Met Thr Gly 
385                 390                 395                 400 


Trp Glu Val Ala Gly Asp His Ile Tyr Thr Ala Ala Gly Ala Ser Asp 
                405                 410                 415     


Asn Asp Phe Met Ile Leu Thr Leu Val Val Pro Gly Phe Arg Pro Pro 
            420                 425                 430         


Gln Ser Val Met Ala Asp Thr Glu Asn Lys Glu Val Ala Arg Ile Thr 
        435                 440                 445             


Phe Val Phe Glu Thr Leu Cys Ser Val Asn Cys Glu Leu Tyr Phe Met 
    450                 455                 460                 


Val Gly Val Asn Ser Arg Thr Asn Thr Pro Val Glu Thr Trp Lys Gly 
465                 470                 475                 480 


Ser Lys Gly Lys Gln Ser Tyr Thr Tyr Ile Ile Glu Glu Asn Thr Thr 
                485                 490                 495     


Thr Ser Phe Thr Trp Ala Phe Gln Arg Thr Thr Phe His Glu Ala Ser 
            500                 505                 510         


Arg Lys Tyr Thr Asn Asp Val Ala Lys Ile Tyr Ser Ile Asn Val Thr 
        515                 520                 525             


Asn Val Met Asn Gly Val Ala Ser Tyr Cys Arg Pro Cys Ala Leu Glu 
    530                 535                 540                 


Ala Ser Asp Val Gly Ser Ser Cys Thr Ser Cys Pro Ala Gly Tyr Tyr 
545                 550                 555                 560 


Ile Asp Arg Asp Ser Gly Thr Cys His Ser Cys Pro Thr Asn Thr Ile 
                565                 570                 575     


Leu Lys Ala His Gln Pro Tyr Gly Val Gln Ala Cys Val Pro Cys Gly 
            580                 585                 590         


Pro Gly Thr Lys Asn Asn Lys Ile His Ser Leu Cys Tyr Asn Asp Cys 
        595                 600                 605             


Thr Phe Ser Arg Asn Thr Pro Thr Arg Thr Phe Asn Tyr Asn Phe Ser 
    610                 615                 620                 


Ala Leu Ala Asn Thr Val Thr Leu Ala Gly Gly Pro Ser Phe Thr Ser 
625                 630                 635                 640 


Lys Gly Leu Lys Tyr Phe His His Phe Thr Leu Ser Leu Cys Gly Asn 
                645                 650                 655     


Gln Gly Arg Lys Met Ser Val Cys Thr Asp Asn Val Thr Asp Leu Arg 
            660                 665                 670         


Ile Pro Glu Gly Glu Ser Gly Phe Ser Lys Ser Ile Thr Ala Tyr Val 
        675                 680                 685             


Cys Gln Ala Val Ile Ile Pro Pro Glu Val Thr Gly Tyr Lys Ala Gly 
    690                 695                 700                 


Val Ser Ser Gln Pro Val Ser Leu Ala Asp Arg Leu Ile Gly Val Thr 
705                 710                 715                 720 


Thr Asp Met Thr Leu Asp Gly Ile Thr Ser Pro Ala Glu Leu Phe His 
                725                 730                 735     


Leu Glu Ser Leu Gly Ile Pro Asp Val Ile Phe Phe Tyr Arg Ser Asn 
            740                 745                 750         


Asp Val Thr Gln Ser Cys Ser Ser Gly Arg Ser Thr Thr Ile Arg Val 
        755                 760                 765             


Arg Cys Ser Pro Gln Lys Thr Val Pro Gly Ser Leu Leu Leu Pro Gly 
    770                 775                 780                 


Thr Cys Ser Asp Gly Thr Cys Asp Gly Cys Asn Phe His Phe Leu Trp 
785                 790                 795                 800 


Glu Ser Ala Ala Ala Cys Pro Leu Cys Ser Val Ala Asp Tyr His Ala 
                805                 810                 815     


Ile Val Ser Ser Cys Val Ala Gly Ile Gln Lys Thr Thr Tyr Val Trp 
            820                 825                 830         


Arg Glu Pro Lys Leu Cys Ser Gly Gly Ile Ser Leu Pro Glu Gln Arg 
        835                 840                 845             


Val Thr Ile Cys Lys Thr Ile Asp Phe Trp Leu Lys Val Gly Ile Ser 
    850                 855                 860                 


Ala Gly Thr Cys Thr Ala Ile Leu Leu Thr Val Leu Thr Cys Tyr Phe 
865                 870                 875                 880 


Trp Lys Lys Asn Gln Lys Leu Glu Tyr Lys Tyr Ser Lys Leu Val Met 
                885                 890                 895     


Asn Ala Thr Leu Lys 
            900     


<210>  7458
<211>  926
<212>  PRT
<213>  Homo Sapiens

<400>  7458

Met Ala Glu Pro Gly His Ser His His Leu Ser Ala Arg Val Arg Gly 
1               5                   10                  15      


Arg Thr Glu Arg Arg Ile Pro Arg Leu Trp Arg Leu Leu Leu Trp Ala 
            20                  25                  30          


Gly Thr Ala Phe Gln Val Thr Gln Gly Thr Gly Pro Glu Leu His Ala 
        35                  40                  45              


Cys Lys Glu Ser Glu Tyr His Tyr Glu Tyr Thr Ala Cys Asp Ser Thr 
    50                  55                  60                  


Gly Ser Arg Trp Arg Val Ala Val Pro His Thr Pro Gly Leu Cys Thr 
65                  70                  75                  80  


Ser Leu Pro Asp Pro Ile Lys Gly Thr Glu Cys Ser Phe Ser Cys Asn 
                85                  90                  95      


Ala Gly Glu Phe Leu Asp Met Lys Asp Gln Ser Cys Lys Pro Cys Ala 
            100                 105                 110         


Glu Gly Arg Tyr Ser Leu Gly Thr Gly Ile Arg Phe Asp Glu Trp Asp 
        115                 120                 125             


Glu Leu Pro His Gly Phe Ala Ser Leu Ser Ala Asn Met Glu Leu Asp 
    130                 135                 140                 


Asp Ser Ala Ala Glu Ser Thr Gly Asn Cys Thr Ser Ser Lys Trp Val 
145                 150                 155                 160 


Pro Arg Gly Asp Tyr Ile Ala Ser Asn Thr Asp Glu Cys Thr Ala Thr 
                165                 170                 175     


Leu Met Tyr Ala Val Asn Leu Lys Gln Ser Gly Thr Val Asn Phe Glu 
            180                 185                 190         


Tyr Tyr Tyr Pro Asp Ser Ser Ile Ile Phe Glu Phe Phe Val Gln Asn 
        195                 200                 205             


Asp Gln Cys Gln Pro Asn Ala Asp Asp Ser Arg Trp Met Lys Thr Thr 
    210                 215                 220                 


Glu Lys Gly Trp Glu Phe His Ser Val Glu Leu Asn Arg Gly Asn Asn 
225                 230                 235                 240 


Val Leu Tyr Trp Arg Thr Thr Ala Phe Ser Val Trp Thr Lys Val Pro 
                245                 250                 255     


Lys Pro Val Leu Thr Gln Leu Met Tyr Lys Trp Ala Lys Pro Lys Ile 
            260                 265                 270         


Cys Ser Glu Asp Leu Glu Gly Ala Val Lys Leu Pro Ala Ser Gly Val 
        275                 280                 285             


Lys Thr His Cys Pro Pro Cys Asn Pro Gly Phe Phe Lys Thr Asn Asn 
    290                 295                 300                 


Ser Thr Cys Gln Pro Cys Pro Tyr Gly Ser Tyr Ser Asn Gly Ser Asp 
305                 310                 315                 320 


Cys Thr Arg Cys Pro Ala Gly Thr Glu Pro Ala Val Gly Phe Glu Tyr 
                325                 330                 335     


Lys Trp Trp Asn Thr Leu Pro Thr Asn Met Glu Thr Thr Val Leu Ser 
            340                 345                 350         


Gly Ile Asn Phe Glu Tyr Lys Gly Met Thr Gly Trp Glu Val Ala Gly 
        355                 360                 365             


Asp His Ile Tyr Thr Ala Ala Gly Ala Ser Asp Asn Asp Phe Met Ile 
    370                 375                 380                 


Leu Thr Leu Val Val Pro Gly Phe Arg Pro Pro Gln Ser Val Met Ala 
385                 390                 395                 400 


Asp Thr Glu Asn Lys Glu Val Ala Arg Ile Thr Phe Val Phe Glu Thr 
                405                 410                 415     


Leu Cys Ser Val Asn Cys Glu Leu Tyr Phe Met Val Gly Val Asn Ser 
            420                 425                 430         


Arg Thr Asn Thr Pro Val Glu Thr Trp Lys Gly Ser Lys Gly Lys Gln 
        435                 440                 445             


Ser Tyr Thr Tyr Ile Ile Glu Glu Asn Thr Thr Thr Ser Phe Thr Trp 
    450                 455                 460                 


Ala Phe Gln Arg Thr Thr Phe His Glu Ala Ser Arg Lys Tyr Thr Asn 
465                 470                 475                 480 


Asp Val Ala Lys Ile Tyr Ser Ile Asn Val Thr Asn Val Met Asn Gly 
                485                 490                 495     


Val Ala Ser Tyr Cys Arg Pro Cys Ala Leu Glu Ala Ser Asp Val Gly 
            500                 505                 510         


Ser Ser Cys Thr Ser Cys Pro Ala Gly Tyr Tyr Ile Asp Arg Asp Ser 
        515                 520                 525             


Gly Thr Cys His Ser Cys Pro Thr Asn Thr Ile Leu Lys Ala His Gln 
    530                 535                 540                 


Pro Tyr Gly Val Gln Ala Cys Val Pro Cys Gly Pro Gly Thr Lys Asn 
545                 550                 555                 560 


Asn Lys Ile His Ser Leu Cys Tyr Asn Asp Cys Thr Phe Ser Arg Asn 
                565                 570                 575     


Thr Pro Thr Arg Thr Phe Asn Tyr Asn Phe Ser Ala Leu Ala Asn Thr 
            580                 585                 590         


Val Thr Leu Ala Gly Gly Pro Ser Phe Thr Ser Lys Gly Leu Lys Tyr 
        595                 600                 605             


Phe His His Phe Thr Leu Ser Leu Cys Gly Asn Gln Gly Arg Lys Met 
    610                 615                 620                 


Ser Val Cys Thr Asp Asn Val Thr Asp Leu Arg Ile Pro Glu Gly Glu 
625                 630                 635                 640 


Ser Gly Phe Ser Lys Ser Ile Thr Ala Tyr Val Cys Gln Ala Val Ile 
                645                 650                 655     


Ile Pro Pro Glu Val Thr Gly Tyr Lys Ala Gly Val Ser Ser Gln Pro 
            660                 665                 670         


Val Ser Leu Ala Asp Arg Leu Ile Gly Val Thr Thr Asp Met Thr Leu 
        675                 680                 685             


Asp Gly Ile Thr Ser Pro Ala Glu Leu Phe His Leu Glu Ser Leu Gly 
    690                 695                 700                 


Ile Pro Asp Val Ile Phe Phe Tyr Arg Ser Asn Asp Val Thr Gln Ser 
705                 710                 715                 720 


Cys Ser Ser Gly Arg Ser Thr Thr Ile Arg Val Arg Cys Ser Pro Gln 
                725                 730                 735     


Lys Thr Val Pro Gly Ser Leu Leu Leu Pro Gly Thr Cys Ser Asp Gly 
            740                 745                 750         


Thr Cys Asp Gly Cys Asn Phe His Phe Leu Trp Glu Ser Ala Ala Ala 
        755                 760                 765             


Cys Pro Leu Cys Ser Val Ala Asp Tyr His Ala Ile Val Ser Ser Cys 
    770                 775                 780                 


Val Ala Gly Ile Gln Lys Thr Thr Tyr Val Trp Arg Glu Pro Lys Leu 
785                 790                 795                 800 


Cys Ser Gly Gly Ile Ser Leu Pro Glu Gln Arg Val Thr Ile Cys Lys 
                805                 810                 815     


Thr Ile Asp Phe Trp Leu Lys Val Gly Ile Ser Ala Gly Thr Cys Thr 
            820                 825                 830         


Ala Ile Leu Leu Thr Val Leu Thr Cys Tyr Phe Trp Lys Lys Asn Gln 
        835                 840                 845             


Lys Leu Glu Tyr Lys Tyr Ser Lys Leu Val Met Asn Ala Thr Leu Lys 
    850                 855                 860                 


Asp Cys Asp Leu Pro Ala Ala Asp Ser Cys Ala Ile Met Glu Gly Glu 
865                 870                 875                 880 


Asp Val Glu Asp Asp Leu Ile Phe Thr Ser Lys Lys Ser Leu Phe Gly 
                885                 890                 895     


Lys Ile Lys Ser Phe Thr Ser Lys Arg Thr Pro Asp Gly Phe Asp Ser 
            900                 905                 910         


Val Pro Leu Lys Thr Ser Ser Gly Gly Leu Asp Met Asp Leu 
        915                 920                 925     


<210>  7459
<211>  838
<212>  PRT
<213>  Homo Sapiens

<400>  7459

Met Tyr Ala Phe Tyr Ser Leu Leu Ile Tyr Ile Phe Tyr Ser Leu Phe 
1               5                   10                  15      


Arg Arg Asp Gly Gly Ala Ala Ala Ala Ala Glu Pro Gly Asp Pro Ala 
            20                  25                  30          


Gln Arg Ala Arg Lys Pro Arg Gly Arg Arg Arg Pro Asp Leu Pro Ala 
        35                  40                  45              


Pro Glu Leu Trp Thr Glu Leu Thr Gly Leu Ala Ala Ser Ser Glu Pro 
    50                  55                  60                  


Glu Asp Gly Ser Glu Gly Ala Ala Glu Gly Arg Ala Ala Ala Val Ser 
65                  70                  75                  80  


Leu Glu Glu Ala Leu Leu Arg Leu Ala Glu Phe Leu Ser Val Gln Leu 
                85                  90                  95      


Gly Ala Glu Glu Ser Cys Gly Gly Pro Ala Asp Leu Gly Gln Ser Gly 
            100                 105                 110         


Glu Val Pro Ser Leu Leu Thr Val Thr Ser Gln Leu Leu Ala Leu Leu 
        115                 120                 125             


Ala Trp Leu Arg Ser Pro Arg Gly Arg Gln Ala Leu Leu Gln Gly Thr 
    130                 135                 140                 


Gln Pro Ala Pro Arg Val Arg Pro Pro Ser Pro Asp Gly Ser Thr Ser 
145                 150                 155                 160 


Gln Glu Glu Ser Pro Ser His Phe Thr Ala Val Pro Gly Glu Pro Leu 
                165                 170                 175     


Gly Asp Glu Thr Gln Gly Gln Gln Pro Leu Gln Leu Glu Glu Asp Gln 
            180                 185                 190         


Arg Ala Trp Gln Arg Leu Glu Gln Leu Ile Leu Gly Gln Leu Glu Glu 
        195                 200                 205             


Leu Lys Gln Gln Leu Glu Gln Gln Glu Glu Glu Leu Gly Arg Leu Arg 
    210                 215                 220                 


Leu Gly Val Gly Ala Thr Asp Ser Glu Lys Arg Val Gln His Leu Thr 
225                 230                 235                 240 


Leu Glu Asn Glu Ala Leu Lys Gln Ser Leu Ser Leu Met Arg Asp Leu 
                245                 250                 255     


Leu Leu His Trp Gly Pro Gly Pro Pro Ile Arg Ala Pro Gln Glu Glu 
            260                 265                 270         


Ala Glu Ala Leu Leu Glu Leu Gln Gly Arg Leu Gln Glu Ala Gln Asp 
        275                 280                 285             


Thr Thr Glu Ala Leu Arg Ala Gln Leu Gly Val Gln Glu Val Gln Leu 
    290                 295                 300                 


Gln Gly Leu Gln Gly Ala Leu Gln Gln Leu Gln Gln Glu Thr Glu Gln 
305                 310                 315                 320 


Asn Cys Arg Arg Glu Leu Gln Gln Met His Gly Gln Leu Ala Gly Leu 
                325                 330                 335     


Arg Ala Arg Met Ala Ser Leu Arg Gln Gly Cys Gly Asp Leu Arg Gly 
            340                 345                 350         


Leu Val Ser Thr Phe Thr Gln Ser Cys Gln Gly Ser Leu Ser Glu Ala 
        355                 360                 365             


Arg Gly Gln Val Ser Trp Ala Leu Gly Ala Leu Ser Ser Gly Gly Pro 
    370                 375                 380                 


Gly Thr Gln Leu Pro Glu Gly Gln Gln Gly Pro Pro Ala Gly Cys Pro 
385                 390                 395                 400 


Gly Arg Leu Pro Glu Leu Lys Gly Asn Ile Arg Val Leu Cys Arg Leu 
                405                 410                 415     


Arg Pro Gly Thr Ser Ser Ser Leu Val Ser Val Glu Pro Gly Pro Gly 
            420                 425                 430         


Gly Thr Val Thr Thr Cys Tyr Arg Gly Arg His Arg Arg Phe Arg Leu 
        435                 440                 445             


Asp Trp Val Phe Pro Pro Asp Ala Ser Gln Glu Glu Val Phe Arg Glu 
    450                 455                 460                 


Leu Glu Pro Ala Val Leu Ser Cys Leu Arg Gly Tyr Ser Val Cys Ile 
465                 470                 475                 480 


Phe Thr Tyr Gly Gln Thr Gly Thr Gly Lys Thr Tyr Ser Met Glu Gly 
                485                 490                 495     


Pro Pro Glu Asp Pro Gly Ile Val Pro Arg Ala Leu Gln Ser Leu Phe 
            500                 505                 510         


Arg Glu Met Gly Ala Gly Arg Gln His Arg Val Thr Leu Ser Met Val 
        515                 520                 525             


Glu Ile Tyr Asn Glu Ala Val Arg Asp Leu Leu Ala Pro Gly Pro Pro 
    530                 535                 540                 


Glu Arg Leu Ala Val Arg Gln Gly Pro Glu Gly Gln Gly Gly Ile Gln 
545                 550                 555                 560 


Val Ala Gly Leu Thr His Trp Asp Val Pro Asn Leu Glu Thr Leu His 
                565                 570                 575     


Gln Met Leu Lys Leu Gly Arg Ser Asn Arg Ala Thr Ala Ala Thr Ala 
            580                 585                 590         


Met Asn Gln Arg Ser Ser Arg Ser His Ala Leu Val Thr Leu Thr Leu 
        595                 600                 605             


Arg Ala Ala Ser Pro Pro Arg Ala Pro Gly Thr Ala Gly Thr Leu His 
    610                 615                 620                 


Leu Val Asp Leu Ala Gly Ser Glu Arg Ala Arg Lys Ala Gly Ala Ala 
625                 630                 635                 640 


Gly Pro Pro Arg Gly Asp Pro Asp Gly Ala Arg Arg Leu Arg Glu Ala 
                645                 650                 655     


Gln Thr Ile Asn Arg Ser Leu Leu Ala Leu Gly Gly Val Met Ala Ala 
            660                 665                 670         


Leu Arg Ala His Arg Pro His Val Pro Phe Arg Asp Ser Gln Leu Thr 
        675                 680                 685             


Arg Leu Leu Gln Pro Ala Leu Gly Pro Gly Thr Thr Ala Val Leu Leu 
    690                 695                 700                 


Leu Gln Val Gly Ala Gly Ala Gly Gln Val Cys Ala Cys Arg Ser Pro 
705                 710                 715                 720 


Pro Thr Arg Ala Arg Pro Pro Ala Pro Leu Ala Arg Arg Ser Pro Arg 
                725                 730                 735     


Gly Arg Arg Ile Ser Gly Arg Gln Ser Ala Pro Ser Ser Ser Pro Thr 
            740                 745                 750         


Glu Trp Val Lys Trp Ser Trp Gly Gln Pro Gly Ala Ala Gly Ser Arg 
        755                 760                 765             


Ala Pro Pro Gly Arg Leu Leu Pro Ser Ala Pro Thr Leu Arg Ser Pro 
    770                 775                 780                 


Gly Pro Pro Ala Pro Leu Arg Arg Pro Leu Ala Val Leu His Ala Pro 
785                 790                 795                 800 


Val Pro Thr Thr Ala Arg Ala Arg Leu Ser Arg Pro Gln Arg Ala Cys 
                805                 810                 815     


Pro Ser Ser Pro Gly Ser Arg Pro Cys Pro Trp Gly Leu Arg Pro Gly 
            820                 825                 830         


Leu Cys Trp Gln Arg Arg 
        835             


<210>  7460
<211>  744
<212>  PRT
<213>  Homo Sapiens

<400>  7460

Met Tyr Ala Phe Tyr Ser Leu Leu Ile Tyr Ile Phe Tyr Ser Leu Phe 
1               5                   10                  15      


Arg Arg Asp Gly Gly Ala Ala Ala Ala Ala Glu Pro Gly Asp Pro Ala 
            20                  25                  30          


Gln Arg Ala Arg Lys Pro Arg Gly Arg Arg Arg Pro Asp Leu Pro Ala 
        35                  40                  45              


Pro Glu Leu Trp Thr Glu Leu Thr Gly Leu Ala Ala Ser Ser Glu Pro 
    50                  55                  60                  


Glu Asp Gly Ser Glu Gly Ala Ala Glu Gly Arg Ala Ala Ala Val Ser 
65                  70                  75                  80  


Leu Glu Glu Ala Leu Leu Arg Leu Ala Glu Phe Leu Ser Val Gln Leu 
                85                  90                  95      


Gly Ala Glu Glu Ser Cys Gly Gly Pro Ala Asp Leu Gly Gln Ser Gly 
            100                 105                 110         


Glu Val Pro Ser Leu Leu Thr Val Thr Ser Gln Leu Leu Ala Leu Leu 
        115                 120                 125             


Ala Trp Leu Arg Ser Pro Arg Gly Arg Gln Ala Leu Leu Gln Gly Thr 
    130                 135                 140                 


Gln Pro Ala Pro Arg Val Arg Pro Pro Ser Pro Asp Gly Ser Thr Ser 
145                 150                 155                 160 


Gln Glu Glu Ser Pro Ser His Phe Thr Ala Val Pro Gly Glu Pro Leu 
                165                 170                 175     


Gly Asp Glu Thr Gln Gly Gln Gln Pro Leu Gln Leu Glu Glu Asp Gln 
            180                 185                 190         


Arg Ala Trp Gln Arg Leu Glu Gln Leu Ile Leu Gly Gln Leu Glu Glu 
        195                 200                 205             


Leu Lys Gln Gln Leu Glu Gln Gln Glu Glu Glu Leu Gly Arg Leu Arg 
    210                 215                 220                 


Leu Gly Val Gly Ala Thr Asp Ser Glu Lys Arg Val Gln His Leu Thr 
225                 230                 235                 240 


Leu Glu Asn Glu Ala Leu Lys Gln Ser Leu Ser Leu Met Arg Asp Leu 
                245                 250                 255     


Leu Leu His Trp Gly Pro Gly Pro Pro Ile Arg Ala Pro Gln Glu Glu 
            260                 265                 270         


Ala Glu Ala Leu Leu Glu Leu Gln Gly Arg Leu Gln Glu Ala Gln Asp 
        275                 280                 285             


Thr Thr Glu Ala Leu Arg Ala Gln Leu Gln Gln Glu Thr Glu Gln Asn 
    290                 295                 300                 


Cys Arg Arg Glu Leu Gln Gln Met His Gly Gln Leu Ala Gly Leu Arg 
305                 310                 315                 320 


Ala Arg Met Ala Ser Leu Arg Gln Gly Cys Gly Asp Leu Arg Gly Leu 
                325                 330                 335     


Val Ser Thr Phe Thr Gln Ser Cys Gln Gly Ser Leu Ser Glu Ala Arg 
            340                 345                 350         


Gly Gln Val Ser Trp Ala Leu Gly Ala Leu Ser Ser Gly Gly Pro Gly 
        355                 360                 365             


Thr Gln Leu Pro Glu Gly Gln Gln Gly Pro Pro Ala Gly Cys Pro Gly 
    370                 375                 380                 


Arg Leu Pro Glu Leu Lys Gly Asn Ile Arg Val Leu Cys Arg Leu Arg 
385                 390                 395                 400 


Pro Gly Thr Ser Ser Ser Leu Val Ser Val Glu Pro Gly Pro Gly Gly 
                405                 410                 415     


Thr Val Thr Thr Cys Tyr Arg Gly Arg His Arg Arg Phe Arg Leu Asp 
            420                 425                 430         


Trp Val Phe Pro Pro Asp Ala Ser Gln Glu Glu Val Phe Arg Glu Leu 
        435                 440                 445             


Glu Pro Ala Val Leu Ser Cys Leu Arg Gly Tyr Ser Val Cys Ile Phe 
    450                 455                 460                 


Thr Tyr Gly Gln Thr Gly Thr Gly Lys Thr Tyr Ser Met Glu Gly Pro 
465                 470                 475                 480 


Pro Glu Asp Pro Gly Ile Val Pro Arg Ala Leu Gln Ser Leu Phe Arg 
                485                 490                 495     


Glu Met Gly Ala Gly Arg Gln His Arg Val Thr Leu Ser Met Val Glu 
            500                 505                 510         


Ile Tyr Asn Glu Ala Val Arg Asp Leu Leu Ala Pro Gly Pro Pro Glu 
        515                 520                 525             


Arg Leu Ala Val Arg Gln Gly Pro Glu Gly Gln Gly Gly Ile Gln Val 
    530                 535                 540                 


Ala Gly Leu Thr His Trp Asp Val Pro Asn Leu Glu Thr Leu His Gln 
545                 550                 555                 560 


Met Leu Lys Leu Gly Arg Ser Asn Arg Ala Thr Ala Ala Thr Ala Met 
                565                 570                 575     


Asn Gln Arg Ser Ser Arg Ser His Ala Leu Val Thr Leu Thr Leu Arg 
            580                 585                 590         


Ala Ala Ser Pro Pro Arg Ala Pro Gly Thr Ala Gly Thr Leu His Leu 
        595                 600                 605             


Val Asp Leu Ala Gly Ser Glu Arg Ala Arg Lys Ala Gly Ala Ala Gly 
    610                 615                 620                 


Pro Pro Arg Gly Asp Pro Asp Gly Ala Arg Arg Leu Arg Glu Ala Gln 
625                 630                 635                 640 


Thr Ile Asn Arg Ser Leu Leu Ala Leu Gly Gly Val Met Ala Ala Leu 
                645                 650                 655     


Arg Ala His Arg Pro His Val Pro Phe Arg Asp Ser Gln Leu Thr Arg 
            660                 665                 670         


Leu Leu Gln Pro Ala Leu Gly Pro Gly Thr Thr Ala Val Leu Leu Leu 
        675                 680                 685             


Gln Ile Ser Thr Arg Pro Glu Asp Leu Gly Glu Thr Val Cys Ser Leu 
    690                 695                 700                 


Lys Phe Ala Asp Arg Val Gly Gln Val Glu Leu Gly Pro Ala Arg Arg 
705                 710                 715                 720 


Arg Arg Val Pro Arg Ser Ser Gly Thr Pro Ser Ser Leu Ser Thr Asp 
                725                 730                 735     


Thr Pro Leu Thr Gly Thr Pro Cys 
            740                 


<210>  7461
<211>  791
<212>  PRT
<213>  Homo Sapiens

<400>  7461

Met Tyr Ala Phe Tyr Ser Leu Leu Ile Tyr Ile Phe Tyr Ser Leu Phe 
1               5                   10                  15      


Arg Arg Asp Gly Gly Ala Ala Ala Ala Ala Glu Pro Gly Asp Pro Ala 
            20                  25                  30          


Gln Arg Ala Arg Lys Pro Arg Gly Arg Arg Arg Pro Asp Leu Pro Ala 
        35                  40                  45              


Pro Glu Leu Trp Thr Glu Leu Thr Gly Leu Ala Ala Ser Ser Glu Pro 
    50                  55                  60                  


Glu Asp Gly Ser Glu Gly Ala Ala Glu Gly Arg Ala Ala Ala Val Ser 
65                  70                  75                  80  


Leu Glu Glu Ala Leu Leu Arg Leu Ala Glu Phe Leu Ser Val Gln Leu 
                85                  90                  95      


Gly Ala Glu Glu Ser Cys Gly Gly Pro Ala Asp Leu Gly Gln Ser Gly 
            100                 105                 110         


Glu Val Pro Ser Leu Leu Thr Val Thr Ser Gln Leu Leu Ala Leu Leu 
        115                 120                 125             


Ala Trp Leu Arg Ser Pro Arg Gly Arg Gln Ala Leu Leu Gln Gly Thr 
    130                 135                 140                 


Gln Pro Ala Pro Arg Val Arg Pro Pro Ser Pro Asp Gly Ser Thr Ser 
145                 150                 155                 160 


Gln Glu Glu Ser Pro Ser His Phe Thr Ala Val Pro Gly Glu Pro Leu 
                165                 170                 175     


Gly Asp Glu Thr Gln Gly Gln Gln Pro Leu Gln Leu Glu Glu Asp Gln 
            180                 185                 190         


Arg Ala Trp Gln Arg Leu Glu Gln Leu Ile Leu Gly Gln Leu Glu Glu 
        195                 200                 205             


Leu Lys Gln Gln Leu Glu Gln Gln Glu Glu Glu Leu Gly Arg Leu Arg 
    210                 215                 220                 


Leu Gly Val Gly Ala Thr Asp Ser Glu Lys Arg Val Gln His Leu Thr 
225                 230                 235                 240 


Leu Glu Asn Glu Ala Leu Lys Gln Ser Leu Ser Leu Met Arg Asp Leu 
                245                 250                 255     


Leu Leu His Trp Gly Pro Gly Pro Pro Ile Arg Ala Pro Gln Glu Glu 
            260                 265                 270         


Ala Glu Ala Leu Leu Glu Leu Gln Gly Arg Leu Gln Glu Ala Gln Asp 
        275                 280                 285             


Thr Thr Glu Ala Leu Arg Ala Gln Leu Gly Val Gln Glu Val Gln Leu 
    290                 295                 300                 


Gln Gly Leu Gln Gly Ala Leu Gln Gln Leu Gln Gln Glu Thr Glu Gln 
305                 310                 315                 320 


Asn Cys Arg Arg Glu Leu Gln Gln Met His Gly Gln Leu Ala Gly Leu 
                325                 330                 335     


Arg Ala Arg Met Ala Ser Leu Arg Gln Gly Cys Gly Asp Leu Arg Gly 
            340                 345                 350         


Leu Val Ser Thr Phe Thr Gln Ser Cys Gln Gly Ser Leu Ser Glu Ala 
        355                 360                 365             


Arg Gly Gln Val Ser Trp Ala Leu Gly Ala Leu Ser Ser Gly Gly Pro 
    370                 375                 380                 


Gly Thr Gln Leu Pro Glu Gly Gln Gln Gly Pro Pro Ala Gly Cys Pro 
385                 390                 395                 400 


Gly Arg Leu Pro Glu Leu Lys Gly Asn Ile Arg Val Leu Cys Arg Leu 
                405                 410                 415     


Arg Pro Gly Thr Ser Ser Ser Leu Val Ser Val Glu Pro Gly Pro Gly 
            420                 425                 430         


Gly Thr Val Thr Thr Cys Tyr Arg Gly Arg His Arg Arg Phe Arg Leu 
        435                 440                 445             


Asp Trp Val Phe Pro Pro Asp Ala Ser Gln Glu Glu Val Phe Arg Glu 
    450                 455                 460                 


Leu Glu Pro Ala Val Leu Ser Cys Leu Arg Gly Tyr Ser Val Cys Ile 
465                 470                 475                 480 


Phe Thr Tyr Gly Gln Thr Gly Thr Gly Lys Thr Tyr Ser Met Glu Gly 
                485                 490                 495     


Pro Pro Glu Asp Pro Gly Ile Val Pro Arg Ala Leu Gln Ser Leu Phe 
            500                 505                 510         


Arg Glu Met Gly Ala Gly Arg Gln His Arg Val Thr Leu Ser Met Val 
        515                 520                 525             


Glu Ile Tyr Asn Glu Ala Val Arg Asp Leu Leu Ala Pro Gly Pro Pro 
    530                 535                 540                 


Glu Arg Leu Ala Val Arg Gln Gly Pro Glu Gly Gln Gly Gly Ile Gln 
545                 550                 555                 560 


Val Ala Gly Leu Thr His Trp Asp Val Pro Asn Leu Glu Thr Leu His 
                565                 570                 575     


Gln Met Leu Lys Leu Gly Arg Ser Asn Arg Ala Thr Ala Ala Thr Ala 
            580                 585                 590         


Met Asn Gln Arg Ser Ser Arg Ser His Ala Leu Val Thr Leu Thr Leu 
        595                 600                 605             


Arg Ala Ala Ser Pro Pro Arg Ala Pro Gly Thr Ala Gly Thr Leu His 
    610                 615                 620                 


Leu Val Asp Leu Ala Gly Ser Glu Arg Ala Arg Lys Ala Gly Ala Ala 
625                 630                 635                 640 


Gly Pro Pro Arg Gly Asp Pro Asp Gly Ala Arg Arg Leu Arg Glu Ala 
                645                 650                 655     


Gln Thr Ile Asn Arg Ser Leu Leu Ala Leu Gly Gly Val Met Ala Ala 
            660                 665                 670         


Leu Arg Ala His Arg Pro His Val Pro Phe Arg Asp Ser Gln Leu Thr 
        675                 680                 685             


Arg Leu Leu Gln Pro Ala Leu Gly Pro Gly Thr Thr Ala Val Leu Leu 
    690                 695                 700                 


Leu Gln Ile Ser Thr Arg Pro Glu Asp Leu Gly Glu Thr Val Cys Ser 
705                 710                 715                 720 


Leu Lys Phe Ala Asp Arg Val Gly Gln Val Glu Leu Gly Pro Ala Arg 
                725                 730                 735     


Arg Arg Arg Val Pro Arg Ser Ser Gly Thr Pro Ser Ser Leu Ser Thr 
            740                 745                 750         


Asp Thr Pro Leu Thr Gly Thr Pro Cys Thr Pro Thr Pro Ser Pro Gly 
        755                 760                 765             


Ser Pro Pro Cys Pro Ser Pro Asp Asn Gly Ser Gly Ser Ala Leu Ala 
    770                 775                 780                 


Pro Ala Glu Gly Leu Pro Leu 
785                 790     


<210>  7462
<211>  325
<212>  PRT
<213>  Homo Sapiens

<400>  7462

Met Ser Met Ser Pro Thr Val Ile Ile Leu Ala Cys Leu Gly Phe Phe 
1               5                   10                  15      


Leu Asp Gln Ser Val Trp Ala His Val Gly Gly Gln Asp Lys Pro Phe 
            20                  25                  30          


Cys Ser Ala Trp Pro Ser Ala Val Val Pro Gln Gly Gly His Val Thr 
        35                  40                  45              


Leu Arg Cys His Tyr Arg Arg Gly Phe Asn Ile Phe Thr Leu Tyr Lys 
    50                  55                  60                  


Lys Asp Gly Val Pro Val Pro Glu Leu Tyr Asn Arg Ile Phe Trp Asn 
65                  70                  75                  80  


Ser Phe Leu Ile Ser Pro Val Thr Pro Ala His Ala Gly Thr Tyr Arg 
                85                  90                  95      


Cys Arg Gly Phe His Pro His Ser Pro Thr Glu Trp Ser Ala Pro Ser 
            100                 105                 110         


Asn Pro Leu Val Ile Met Val Thr Gly Leu Tyr Glu Lys Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Pro Gly Pro Thr Val Arg Ala Gly Glu Asn Val Thr Leu 
    130                 135                 140                 


Ser Cys Ser Ser Gln Ser Ser Phe Asp Ile Tyr His Leu Ser Arg Glu 
145                 150                 155                 160 


Gly Glu Ala His Glu Leu Arg Leu Pro Ala Val Pro Ser Ile Asn Gly 
                165                 170                 175     


Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly Glu Thr 
            180                 185                 190         


Tyr Arg Cys Phe Gly Ser Phe His Gly Ser Pro Tyr Glu Trp Ser Asp 
        195                 200                 205             


Pro Ser Asp Pro Leu Pro Val Ser Val Thr Asp Ala Ala Val Met Asn 
    210                 215                 220                 


Gln Glu Pro Ala Gly His Arg Thr Val Asn Arg Glu Asp Ser Asp Glu 
225                 230                 235                 240 


Gln Asp Pro Gln Glu Val Thr Tyr Ala Gln Leu Asp His Cys Ile Phe 
                245                 250                 255     


Thr Gln Arg Lys Ile Thr Gly Pro Ser Gln Arg Ser Lys Arg Pro Ser 
            260                 265                 270         


Thr Asp Thr Ser Val Cys Ile Glu Leu Pro Asn Ala Glu Pro Arg Ala 
        275                 280                 285             


Leu Ser Pro Ala His Glu His His Ser Gln Ala Leu Met Gly Ser Ser 
    290                 295                 300                 


Arg Glu Thr Thr Ala Leu Ser Gln Thr Gln Leu Ala Ser Ser Asn Val 
305                 310                 315                 320 


Pro Ala Ala Gly Ile 
                325 


<210>  7463
<211>  342
<212>  PRT
<213>  Homo Sapiens

<400>  7463

Met Ser Met Ser Pro Thr Val Ile Ile Leu Ala Cys Leu Gly Phe Phe 
1               5                   10                  15      


Leu Asp Gln Ser Val Trp Ala His Val Gly Gly Gln Asp Lys Pro Phe 
            20                  25                  30          


Cys Ser Ala Trp Pro Ser Ala Val Val Pro Gln Gly Gly His Val Thr 
        35                  40                  45              


Leu Arg Cys His Tyr Arg Arg Gly Phe Asn Ile Phe Thr Leu Tyr Lys 
    50                  55                  60                  


Lys Asp Gly Val Pro Val Pro Glu Leu Tyr Asn Arg Ile Phe Trp Asn 
65                  70                  75                  80  


Ser Phe Leu Ile Ser Pro Val Thr Pro Ala His Ala Gly Thr Tyr Arg 
                85                  90                  95      


Cys Arg Gly Phe His Pro His Ser Pro Thr Glu Trp Ser Ala Pro Ser 
            100                 105                 110         


Asn Pro Leu Val Ile Met Val Thr Gly Leu Tyr Glu Lys Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Pro Gly Pro Thr Val Arg Ala Gly Glu Asn Val Thr Leu 
    130                 135                 140                 


Ser Cys Ser Ser Gln Ser Ser Phe Asp Ile Tyr His Leu Ser Arg Glu 
145                 150                 155                 160 


Gly Glu Ala His Glu Leu Arg Leu Pro Ala Val Pro Ser Ile Asn Gly 
                165                 170                 175     


Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly Glu Thr 
            180                 185                 190         


Tyr Arg Cys Phe Gly Ser Phe His Gly Ser Pro Tyr Glu Trp Ser Asp 
        195                 200                 205             


Pro Ser Asp Pro Leu Pro Val Ser Val Thr Gly Asn Pro Ser Ser Ser 
    210                 215                 220                 


Trp Pro Ser Pro Thr Glu Pro Ser Phe Lys Thr Asp Ala Ala Val Met 
225                 230                 235                 240 


Asn Gln Glu Pro Ala Gly His Arg Thr Val Asn Arg Glu Asp Ser Asp 
                245                 250                 255     


Glu Gln Asp Pro Gln Glu Val Thr Tyr Ala Gln Leu Asp His Cys Ile 
            260                 265                 270         


Phe Thr Gln Arg Lys Ile Thr Gly Pro Ser Gln Arg Ser Lys Arg Pro 
        275                 280                 285             


Ser Thr Asp Thr Ser Val Cys Ile Glu Leu Pro Asn Ala Glu Pro Arg 
    290                 295                 300                 


Ala Leu Ser Pro Ala His Glu His His Ser Gln Ala Leu Met Gly Ser 
305                 310                 315                 320 


Ser Arg Glu Thr Thr Ala Leu Ser Gln Thr Gln Leu Ala Ser Ser Asn 
                325                 330                 335     


Val Pro Ala Ala Gly Ile 
            340         


<210>  7464
<211>  273
<212>  PRT
<213>  Homo Sapiens

<400>  7464

Met Ser Met Ser Pro Thr Val Ile Ile Leu Ala Cys Leu Gly Phe Phe 
1               5                   10                  15      


Leu Asp Gln Ser Val Trp Ala His Val Gly Gly Gln Asp Lys Pro Phe 
            20                  25                  30          


Cys Ser Ala Trp Pro Ser Ala Val Val Pro Gln Gly Gly His Val Thr 
        35                  40                  45              


Leu Arg Cys His Tyr Arg Arg Gly Phe Asn Ile Phe Thr Leu Tyr Lys 
    50                  55                  60                  


Lys Asp Gly Val Pro Val Pro Glu Leu Tyr Asn Arg Ile Phe Trp Asn 
65                  70                  75                  80  


Ser Phe Leu Ile Ser Pro Val Thr Pro Ala His Ala Gly Thr Tyr Arg 
                85                  90                  95      


Cys Arg Gly Phe His Pro His Ser Pro Thr Glu Trp Ser Ala Pro Ser 
            100                 105                 110         


Asn Pro Leu Val Ile Met Val Thr Gly Leu Tyr Glu Lys Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Pro Gly Pro Thr Val Arg Ala Gly Glu Asn Val Thr Leu 
    130                 135                 140                 


Ser Cys Ser Ser Gln Ser Ser Phe Asp Ile Tyr His Leu Ser Arg Glu 
145                 150                 155                 160 


Gly Glu Ala His Glu Leu Arg Leu Pro Ala Val Pro Ser Ile Asn Gly 
                165                 170                 175     


Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly Glu Thr 
            180                 185                 190         


Tyr Arg Cys Phe Gly Ser Phe His Gly Ser Pro Tyr Glu Trp Ser Asp 
        195                 200                 205             


Pro Ser Asp Pro Leu Pro Val Ser Val Thr Gly Asn Pro Ser Ser Ser 
    210                 215                 220                 


Trp Pro Ser Pro Thr Glu Pro Ser Phe Lys Thr Gly Ile Ala Arg His 
225                 230                 235                 240 


Leu His Ala Val Ile Arg Tyr Ser Val Ala Ile Ile Leu Phe Thr Ile 
                245                 250                 255     


Leu Pro Phe Phe Leu Leu His Arg Trp Cys Ser Lys Lys Lys Met Leu 
            260                 265                 270         


Leu 
    


<210>  7465
<211>  230
<212>  PRT
<213>  Homo Sapiens

<400>  7465

Met Ser Met Ser Pro Thr Val Ile Ile Leu Ala Cys Leu Gly Phe Phe 
1               5                   10                  15      


Leu Asp Gln Ser Val Trp Ala His Val Gly Leu Tyr Glu Lys Pro Ser 
            20                  25                  30          


Leu Thr Ala Arg Pro Gly Pro Thr Val Arg Ala Gly Glu Asn Val Thr 
        35                  40                  45              


Leu Ser Cys Ser Ser Gln Ser Ser Phe Asp Ile Tyr His Leu Ser Arg 
    50                  55                  60                  


Glu Gly Glu Ala His Glu Leu Arg Leu Pro Ala Val Pro Ser Ile Asn 
65                  70                  75                  80  


Gly Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly Glu 
                85                  90                  95      


Thr Tyr Arg Cys Phe Gly Ser Phe His Gly Ser Pro Tyr Glu Trp Ser 
            100                 105                 110         


Asp Pro Ser Asp Pro Leu Pro Val Ser Val Thr Asp Ala Ala Val Met 
        115                 120                 125             


Asn Gln Glu Pro Ala Gly His Arg Thr Val Asn Arg Glu Asp Ser Asp 
    130                 135                 140                 


Glu Gln Asp Pro Gln Glu Val Thr Tyr Ala Gln Leu Asp His Cys Ile 
145                 150                 155                 160 


Phe Thr Gln Arg Lys Ile Thr Gly Pro Ser Gln Arg Ser Lys Arg Pro 
                165                 170                 175     


Ser Thr Asp Thr Ser Val Cys Ile Glu Leu Pro Asn Ala Glu Pro Arg 
            180                 185                 190         


Ala Leu Ser Pro Ala His Glu His His Ser Gln Ala Leu Met Gly Ser 
        195                 200                 205             


Ser Arg Glu Thr Thr Ala Leu Ser Gln Thr Gln Leu Ala Ser Ser Asn 
    210                 215                 220                 


Val Pro Ala Ala Gly Ile 
225                 230 


<210>  7466
<211>  247
<212>  PRT
<213>  Homo Sapiens

<400>  7466

Met Ser Met Ser Pro Thr Val Ile Ile Leu Ala Cys Leu Gly Phe Phe 
1               5                   10                  15      


Leu Asp Gln Ser Val Trp Ala His Val Gly Leu Tyr Glu Lys Pro Ser 
            20                  25                  30          


Leu Thr Ala Arg Pro Gly Pro Thr Val Arg Ala Gly Glu Asn Val Thr 
        35                  40                  45              


Leu Ser Cys Ser Ser Gln Ser Ser Phe Asp Ile Tyr His Leu Ser Arg 
    50                  55                  60                  


Glu Gly Glu Ala His Glu Leu Arg Leu Pro Ala Val Pro Ser Ile Asn 
65                  70                  75                  80  


Gly Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly Glu 
                85                  90                  95      


Thr Tyr Arg Cys Phe Gly Ser Phe His Gly Ser Pro Tyr Glu Trp Ser 
            100                 105                 110         


Asp Pro Ser Asp Pro Leu Pro Val Ser Val Thr Gly Asn Pro Ser Ser 
        115                 120                 125             


Ser Trp Pro Ser Pro Thr Glu Pro Ser Phe Lys Thr Asp Ala Ala Val 
    130                 135                 140                 


Met Asn Gln Glu Pro Ala Gly His Arg Thr Val Asn Arg Glu Asp Ser 
145                 150                 155                 160 


Asp Glu Gln Asp Pro Gln Glu Val Thr Tyr Ala Gln Leu Asp His Cys 
                165                 170                 175     


Ile Phe Thr Gln Arg Lys Ile Thr Gly Pro Ser Gln Arg Ser Lys Arg 
            180                 185                 190         


Pro Ser Thr Asp Thr Ser Val Cys Ile Glu Leu Pro Asn Ala Glu Pro 
        195                 200                 205             


Arg Ala Leu Ser Pro Ala His Glu His His Ser Gln Ala Leu Met Gly 
    210                 215                 220                 


Ser Ser Arg Glu Thr Thr Ala Leu Ser Gln Thr Gln Leu Ala Ser Ser 
225                 230                 235                 240 


Asn Val Pro Ala Ala Gly Ile 
                245         


<210>  7467
<211>  416
<212>  PRT
<213>  Homo Sapiens

<400>  7467

Met Ser Pro Ser His Val Val Val Asn Val Ser Thr Ala Arg Ser Gly 
1               5                   10                  15      


Pro Leu Thr Thr Ser Ser Ala Pro Val Ser Arg Ala Glu Ser Leu Arg 
            20                  25                  30          


Pro Gly Ser Arg Ser Cys Thr Met Ser Met Ser Pro Thr Val Ile Ile 
        35                  40                  45              


Leu Ala Cys Leu Gly Phe Phe Leu Asp Gln Ser Val Trp Ala His Val 
    50                  55                  60                  


Gly Gly Gln Asp Lys Pro Phe Cys Ser Ala Trp Pro Ser Ala Val Val 
65                  70                  75                  80  


Pro Gln Gly Gly His Val Thr Leu Arg Cys His Tyr Arg Arg Gly Phe 
                85                  90                  95      


Asn Ile Phe Thr Leu Tyr Lys Lys Asp Gly Val Pro Val Pro Glu Leu 
            100                 105                 110         


Tyr Asn Arg Ile Phe Trp Asn Ser Phe Leu Ile Ser Pro Val Thr Pro 
        115                 120                 125             


Ala His Ala Gly Thr Tyr Arg Cys Arg Gly Phe His Pro His Ser Pro 
    130                 135                 140                 


Thr Glu Trp Ser Ala Pro Ser Asn Pro Leu Val Ile Met Val Thr Gly 
145                 150                 155                 160 


Leu Tyr Glu Lys Pro Ser Leu Thr Ala Arg Pro Gly Pro Thr Val Arg 
                165                 170                 175     


Ala Gly Glu Asn Val Thr Leu Ser Cys Ser Ser Gln Ser Ser Phe Asp 
            180                 185                 190         


Ile Tyr His Leu Ser Arg Glu Gly Glu Ala His Glu Leu Arg Leu Pro 
        195                 200                 205             


Ala Val Pro Ser Ile Asn Gly Thr Phe Gln Ala Asp Phe Pro Leu Gly 
    210                 215                 220                 


Pro Ala Thr His Gly Glu Thr Tyr Arg Cys Phe Gly Ser Phe His Gly 
225                 230                 235                 240 


Ser Pro Tyr Glu Trp Ser Asp Pro Ser Asp Pro Leu Pro Val Ser Val 
                245                 250                 255     


Thr Gly Asn Pro Ser Ser Ser Trp Pro Ser Pro Thr Glu Pro Ser Phe 
            260                 265                 270         


Lys Thr Gly Ile Ala Arg His Leu His Ala Val Ile Arg Tyr Ser Val 
        275                 280                 285             


Ala Ile Ile Leu Phe Thr Ile Leu Pro Phe Phe Leu Leu His Arg Trp 
    290                 295                 300                 


Cys Ser Lys Lys Lys Asp Ala Ala Val Met Asn Gln Glu Pro Ala Gly 
305                 310                 315                 320 


His Arg Thr Val Asn Arg Glu Asp Ser Asp Glu Gln Asp Pro Gln Glu 
                325                 330                 335     


Val Thr Tyr Ala Gln Leu Asp His Cys Ile Phe Thr Gln Arg Lys Ile 
            340                 345                 350         


Thr Gly Pro Ser Gln Arg Ser Lys Arg Pro Ser Thr Asp Thr Ser Val 
        355                 360                 365             


Cys Ile Glu Leu Pro Asn Ala Glu Pro Arg Ala Leu Ser Pro Ala His 
    370                 375                 380                 


Glu His His Ser Gln Ala Leu Met Gly Ser Ser Arg Glu Thr Thr Ala 
385                 390                 395                 400 


Leu Ser Gln Thr Gln Leu Ala Ser Ser Asn Val Pro Ala Ala Gly Ile 
                405                 410                 415     


<210>  7468
<211>  398
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7468

Xaa Met Ser Pro Thr Val Ile Ile Leu Ala Cys Leu Gly Phe Phe Leu 
1               5                   10                  15      


Asp Gln Ser Val Trp Ala His Val Gly Gly Gln Asp Lys Pro Phe Cys 
            20                  25                  30          


Ser Ala Trp Pro Ser Ala Val Val Pro Gln Gly Gly His Val Thr Leu 
        35                  40                  45              


Arg Cys His Tyr Arg Arg Gly Phe Asn Ile Phe Thr Leu Tyr Lys Lys 
    50                  55                  60                  


Asp Gly Val Pro Val Pro Glu Leu Tyr Asn Arg Ile Phe Trp Asn Ser 
65                  70                  75                  80  


Phe Leu Ile Ser Pro Val Thr Pro Ala His Ala Gly Thr Tyr Arg Cys 
                85                  90                  95      


Arg Gly Phe His Pro His Ser Pro Thr Glu Trp Ser Ala Pro Ser Asn 
            100                 105                 110         


Pro Leu Val Ile Met Val Thr Gly Leu Tyr Glu Lys Pro Ser Leu Thr 
        115                 120                 125             


Ala Arg Pro Gly Pro Thr Val Arg Ala Gly Glu Asn Val Thr Leu Ser 
    130                 135                 140                 


Cys Ser Ser Gln Ser Ser Phe Asp Ile Tyr His Leu Ser Arg Glu Gly 
145                 150                 155                 160 


Glu Ala His Glu Leu Arg Leu Pro Ala Val Pro Ser Ile Asn Gly Thr 
                165                 170                 175     


Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly Glu Thr Tyr 
            180                 185                 190         


Arg Cys Phe Gly Ser Phe His Gly Ser Pro Tyr Glu Trp Ser Asp Pro 
        195                 200                 205             


Ser Asp Pro Leu Pro Val Ser Val Thr Gly Asn Pro Ser Ser Ser Trp 
    210                 215                 220                 


Pro Ser Pro Thr Glu Pro Ser Phe Lys Thr Gly Ile Ala Arg His Leu 
225                 230                 235                 240 


His Ala Val Ile Arg Tyr Ser Val Ala Ile Ile Leu Phe Thr Ile Leu 
                245                 250                 255     


Pro Phe Phe Leu Leu His Arg Trp Cys Ser Lys Lys Lys Val Ser Leu 
            260                 265                 270         


Thr Lys Gln Arg Pro Glu Asn Ser Gly Pro Cys Ala Glu Ala Gly Trp 
        275                 280                 285             


Glu His Ala Asp Ala Ala Val Met Asn Gln Glu Pro Ala Gly His Arg 
    290                 295                 300                 


Thr Val Asn Arg Glu Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr 
305                 310                 315                 320 


Tyr Ala Gln Leu Asp His Cys Ile Phe Thr Gln Arg Lys Ile Thr Gly 
                325                 330                 335     


Pro Ser Gln Arg Ser Lys Arg Pro Ser Thr Asp Thr Ser Val Cys Ile 
            340                 345                 350         


Glu Leu Pro Asn Ala Glu Pro Arg Ala Leu Ser Pro Ala His Glu His 
        355                 360                 365             


His Ser Gln Ala Leu Met Gly Ser Ser Arg Glu Thr Thr Ala Leu Ser 
    370                 375                 380                 


Gln Thr Gln Leu Ala Ser Ser Asn Val Pro Ala Ala Gly Ile 
385                 390                 395             


<210>  7469
<211>  139
<212>  PRT
<213>  Homo Sapiens

<400>  7469

Met Ala Pro Lys Leu Ile Thr Val Leu Cys Leu Gly Phe Cys Leu Asn 
1               5                   10                  15      


Gln Lys Ile Cys Pro His Ala Gly Ala Gln Asp Lys Phe Ser Leu Ser 
            20                  25                  30          


Ala Trp Pro Ser Pro Val Val Pro Leu Gly Gly Arg Val Thr Leu Ser 
        35                  40                  45              


Cys His Ser His Leu Arg Phe Val Ile Trp Thr Ile Phe Gln Thr Thr 
    50                  55                  60                  


Gly Thr Arg Ser His Glu Leu His Thr Gly Leu Ser Asn Asn Ile Thr 
65                  70                  75                  80  


Ile Ser Pro Val Thr Pro Glu His Ala Gly Thr Tyr Arg Cys Val Gly 
                85                  90                  95      


Ile Tyr Lys His Ala Ser Lys Trp Ser Ala Glu Ser Asn Ser Leu Lys 
            100                 105                 110         


Ile Ile Val Thr Ala Phe Ser Leu His Pro Gly Gly Pro His Asp Glu 
        115                 120                 125             


Ala Gly Arg Glu Val Asp Pro Leu Leu Gln Leu 
    130                 135                 


<210>  7470
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  7470

Met Ala Pro Lys Leu Ile Thr Val Leu Cys Leu Gly Phe Cys Leu Asn 
1               5                   10                  15      


Gln Lys Ile Cys Pro His Ala Gly Ala Gln Asp Lys Phe Ser Leu Ser 
            20                  25                  30          


Ala Trp Pro Ser Pro Val Val Pro Leu Gly Gly Arg Val Thr Leu Ser 
        35                  40                  45              


Cys His Ser His Leu Arg Phe Val Ile Trp Thr Ile Phe Gln Thr Thr 
    50                  55                  60                  


Gly Thr Arg Ser His Glu Leu His Thr Gly Leu Ser Asn Asn Ile Thr 
65                  70                  75                  80  


Ile Ser Pro Val Thr Pro Glu His Ala Gly Thr Tyr Arg Cys Val Gly 
                85                  90                  95      


Ile Tyr Lys His Ala Ser Lys Trp Ser Ala Glu Ser Asn Ser Leu Lys 
            100                 105                 110         


Ile Ile Val Thr Gly Gly Pro His Asp Glu Ala Gly Arg Glu Val Asp 
        115                 120                 125             


Pro Leu Leu Gln Leu 
    130             


<210>  7471
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  7471

Met Ala Pro Lys Leu Ile Thr Val Leu Cys Leu Gly Phe Cys Leu Asn 
1               5                   10                  15      


Gln Lys Ile Cys Pro His Ala Gly Ala Gln Asp Lys Phe Ser Leu Ser 
            20                  25                  30          


Ala Trp Pro Ser Pro Val Val Pro Leu Gly Gly Arg Val Thr Leu Ser 
        35                  40                  45              


Cys His Ser His Leu Arg Phe Val Ile Trp Thr Ile Phe Gln Thr Thr 
    50                  55                  60                  


Gly Thr Arg Ser His Glu Leu His Thr Gly Leu Ser Asn Asn Ile Thr 
65                  70                  75                  80  


Ile Ser Pro Val Thr Pro Glu His Ala Gly Thr Tyr Arg Cys Val Gly 
                85                  90                  95      


Ile Tyr Lys His Ala Ser Lys Trp Ser Ala Glu Ser Asn Ser Leu Lys 
            100                 105                 110         


Ile Ile Val Thr Gly Gly Pro His Asp Glu Ala Gly Arg Glu Val Asp 
        115                 120                 125             


Pro Leu Leu Gln Leu 
    130             


<210>  7472
<211>  352
<212>  PRT
<213>  Homo Sapiens

<400>  7472

Met Ala Pro Lys Leu Ile Thr Val Leu Cys Leu Gly Phe Cys Leu Asn 
1               5                   10                  15      


Gln Lys Ile Cys Pro His Ala Gly Ala Gln Asp Lys Phe Ser Leu Ser 
            20                  25                  30          


Ala Trp Pro Ser Pro Val Val Pro Leu Gly Gly Arg Val Thr Leu Ser 
        35                  40                  45              


Cys His Ser His Leu Arg Phe Val Ile Trp Thr Ile Phe Gln Thr Thr 
    50                  55                  60                  


Gly Thr Arg Ser His Glu Leu His Thr Gly Leu Ser Asn Asn Ile Thr 
65                  70                  75                  80  


Ile Ser Pro Val Thr Pro Glu His Ala Gly Thr Tyr Arg Cys Val Gly 
                85                  90                  95      


Ile Tyr Lys His Ala Ser Lys Trp Ser Ala Glu Ser Asn Ser Leu Lys 
            100                 105                 110         


Ile Ile Val Thr Gly Leu Phe Thr Lys Pro Ser Ile Ser Ala His Pro 
        115                 120                 125             


Ser Ser Leu Val His Ala Gly Ala Arg Val Ser Leu Arg Cys His Ser 
    130                 135                 140                 


Glu Leu Ala Phe Asp Glu Phe Ile Leu Tyr Lys Glu Gly His Ile Gln 
145                 150                 155                 160 


His Ser Gln Gln Leu Asp Gln Gly Met Glu Ala Gly Ile His Tyr Val 
                165                 170                 175     


Glu Ala Val Phe Ser Met Gly Pro Val Thr Pro Ala His Ala Gly Ala 
            180                 185                 190         


Tyr Arg Cys Cys Gly Cys Phe Ser His Ser Arg Tyr Glu Trp Ser Ala 
        195                 200                 205             


Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly Lys Tyr Lys Lys Pro 
    210                 215                 220                 


Ser Leu Ser Thr Gln Val Asp Pro Met Met Arg Leu Gly Glu Lys Leu 
225                 230                 235                 240 


Thr Leu Phe Cys Ser Ser Glu Ile Ser Phe Asp Gln Tyr His Leu Phe 
                245                 250                 255     


Arg His Gly Val Ala His Gly Gln Trp Leu Ser Gly Gly Gln Arg His 
            260                 265                 270         


Arg Glu Ala Phe Gln Ala Asn Phe Ser Val Gly Arg Ala Thr Pro Val 
        275                 280                 285             


Pro Gly Gly Thr Tyr Arg Cys Tyr Gly Ser Phe Asn Asp Ser Pro Tyr 
    290                 295                 300                 


Lys Pro Pro Val Thr Arg Cys Asn Phe Thr Pro Gln Glu Thr Leu Arg 
305                 310                 315                 320 


Val Leu Leu Cys His Ser Gln Asn Pro Pro Leu Asn Leu Thr His Leu 
                325                 330                 335     


Ala Leu Lys Asp Ser Pro Ala Thr Cys Ile Cys Ser Leu Asp Ser Gln 
            340                 345                 350         


<210>  7473
<211>  365
<212>  PRT
<213>  Homo Sapiens

<400>  7473

Met Ala Pro Lys Leu Ile Thr Val Leu Cys Leu Gly Phe Cys Leu Asn 
1               5                   10                  15      


Gln Lys Ile Cys Pro His Ala Gly Ala Gln Asp Lys Phe Ser Leu Ser 
            20                  25                  30          


Ala Trp Pro Ser Pro Val Val Pro Leu Gly Gly Arg Val Thr Leu Ser 
        35                  40                  45              


Cys His Ser His Leu Arg Phe Val Ile Trp Thr Ile Phe Gln Thr Thr 
    50                  55                  60                  


Gly Thr Arg Ser His Glu Leu His Thr Gly Leu Ser Asn Asn Ile Thr 
65                  70                  75                  80  


Ile Ser Pro Val Thr Pro Glu His Ala Gly Thr Tyr Arg Cys Val Gly 
                85                  90                  95      


Ile Tyr Lys His Ala Ser Lys Trp Ser Ala Glu Ser Asn Ser Leu Lys 
            100                 105                 110         


Ile Ile Val Thr Gly Leu Phe Thr Lys Pro Ser Ile Ser Ala His Pro 
        115                 120                 125             


Ser Ser Leu Val His Ala Gly Ala Arg Val Ser Leu Arg Cys His Ser 
    130                 135                 140                 


Glu Leu Ala Phe Asp Glu Phe Ile Leu Tyr Lys Glu Gly His Ile Gln 
145                 150                 155                 160 


His Ser Gln Gln Leu Asp Gln Gly Met Glu Ala Gly Ile His Tyr Val 
                165                 170                 175     


Glu Ala Val Phe Ser Met Gly Pro Val Thr Pro Ala His Ala Gly Ala 
            180                 185                 190         


Tyr Arg Cys Cys Gly Cys Phe Ser His Ser Arg Tyr Glu Trp Ser Ala 
        195                 200                 205             


Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly Lys Tyr Lys Lys Pro 
    210                 215                 220                 


Ser Leu Ser Thr Gln Val Asp Pro Met Met Arg Leu Gly Glu Lys Leu 
225                 230                 235                 240 


Thr Leu Phe Cys Ser Ser Glu Ile Ser Phe Asp Gln Tyr His Leu Phe 
                245                 250                 255     


Arg His Gly Val Ala His Gly Gln Trp Leu Ser Gly Gly Gln Arg His 
            260                 265                 270         


Arg Glu Ala Phe Gln Ala Asn Phe Ser Val Gly Arg Ala Thr Pro Val 
        275                 280                 285             


Pro Gly Gly Thr Tyr Arg Cys Tyr Gly Ser Phe Asn Asp Ser Pro Tyr 
    290                 295                 300                 


Lys Pro Pro Val Thr Arg Cys Asn Phe Thr Pro Gln Glu Thr Leu Arg 
305                 310                 315                 320 


Val Leu Leu Cys His Ser Gln Asn Pro Pro Leu Asn Leu Thr Pro Pro 
                325                 330                 335     


Trp Gln Thr Gln Ser Pro Arg Lys Ala Asn Gly Arg Met Lys Arg Ser 
            340                 345                 350         


Leu Gln Gln Lys Arg His Arg Arg Ser Tyr Met Pro Ser 
        355                 360                 365 


<210>  7474
<211>  191
<212>  PRT
<213>  Homo Sapiens

<400>  7474

Met Leu Arg Met Arg Val Pro Ala Leu Leu Val Leu Leu Phe Cys Phe 
1               5                   10                  15      


Arg Gly Arg Ala Gly Pro Ser Pro His Phe Leu Gln Gln Pro Glu Asp 
            20                  25                  30          


Leu Val Val Leu Leu Gly Glu Glu Ala Arg Leu Pro Cys Ala Leu Gly 
        35                  40                  45              


Ala Tyr Trp Gly Leu Val Gln Trp Thr Lys Ser Gly Leu Ala Leu Gly 
    50                  55                  60                  


Gly Gln Arg Asp Leu Pro Gly Trp Ser Arg Tyr Trp Ile Ser Gly Asn 
65                  70                  75                  80  


Ala Ala Asn Gly Gln His Asp Leu His Ile Arg Pro Val Glu Leu Glu 
                85                  90                  95      


Asp Glu Ala Ser Tyr Glu Cys Gln Ala Thr Gln Ala Gly Leu Arg Ser 
            100                 105                 110         


Arg Pro Ala Gln Leu His Val Leu Val Pro Pro Glu Ala Pro Gln Val 
        115                 120                 125             


Leu Gly Gly Pro Ser Val Ser Leu Val Ala Gly Val Pro Ala Asn Leu 
    130                 135                 140                 


Thr Cys Arg Ser Arg Gly Asp Ala Arg Pro Thr Pro Glu Leu Leu Trp 
145                 150                 155                 160 


Phe Arg Asp Gly Val Leu Leu Asp Gly Ala Thr Phe His Gln Thr Leu 
                165                 170                 175     


Leu Lys Glu Gly Thr Pro Gly Ser Val Glu Ser Thr Leu Thr Leu 
            180                 185                 190     


<210>  7475
<211>  633
<212>  PRT
<213>  Homo Sapiens

<400>  7475

Met Leu Arg Met Arg Val Pro Ala Leu Leu Val Leu Leu Phe Cys Phe 
1               5                   10                  15      


Arg Gly Arg Ala Gly Pro Ser Pro His Phe Leu Gln Gln Pro Glu Asp 
            20                  25                  30          


Leu Val Val Leu Leu Gly Glu Glu Ala Arg Leu Pro Cys Ala Leu Gly 
        35                  40                  45              


Ala Tyr Trp Gly Leu Val Gln Trp Thr Lys Ser Gly Leu Ala Leu Gly 
    50                  55                  60                  


Gly Gln Arg Asp Leu Pro Gly Trp Ser Arg Tyr Trp Ile Ser Gly Asn 
65                  70                  75                  80  


Ala Ala Asn Gly Gln His Asp Leu His Ile Arg Pro Val Glu Leu Glu 
                85                  90                  95      


Asp Glu Ala Ser Tyr Glu Cys Gln Ala Thr Gln Ala Gly Leu Arg Ser 
            100                 105                 110         


Arg Pro Ala Gln Leu His Val Leu Val Pro Pro Glu Ala Pro Gln Val 
        115                 120                 125             


Leu Gly Gly Pro Ser Val Ser Leu Val Ala Gly Val Pro Ala Asn Leu 
    130                 135                 140                 


Thr Cys Arg Ser Arg Gly Asp Ala Arg Pro Thr Pro Glu Leu Leu Trp 
145                 150                 155                 160 


Phe Arg Asp Gly Val Leu Leu Asp Gly Ala Thr Phe His Gln Thr Leu 
                165                 170                 175     


Leu Lys Glu Gly Thr Pro Gly Ser Val Glu Ser Thr Leu Thr Leu Thr 
            180                 185                 190         


Pro Phe Ser His Asp Asp Gly Ala Thr Phe Val Cys Arg Ala Arg Ser 
        195                 200                 205             


Gln Ala Leu Pro Thr Gly Arg Asp Thr Ala Ile Thr Leu Ser Leu Gln 
    210                 215                 220                 


Tyr Pro Pro Glu Val Thr Leu Ser Ala Ser Pro His Thr Val Gln Glu 
225                 230                 235                 240 


Gly Glu Lys Val Ile Phe Leu Cys Gln Ala Thr Ala Gln Pro Pro Val 
                245                 250                 255     


Thr Gly Tyr Arg Trp Ala Lys Gly Gly Ser Pro Val Leu Gly Ala Arg 
            260                 265                 270         


Gly Pro Arg Leu Glu Val Val Ala Asp Ala Ser Phe Leu Thr Glu Pro 
        275                 280                 285             


Val Ser Cys Glu Val Ser Asn Ala Val Gly Ser Ala Asn Arg Ser Thr 
    290                 295                 300                 


Ala Leu Asp Val Leu Phe Gly Pro Ile Leu Gln Ala Lys Pro Glu Pro 
305                 310                 315                 320 


Val Ser Val Asp Val Gly Glu Asp Ala Ser Phe Ser Cys Ala Trp Arg 
                325                 330                 335     


Gly Asn Pro Leu Pro Arg Val Thr Trp Thr Arg Arg Gly Gly Ala Gln 
            340                 345                 350         


Val Leu Gly Ser Gly Ala Thr Leu Arg Leu Pro Ser Val Gly Pro Glu 
        355                 360                 365             


Asp Ala Gly Asp Tyr Val Cys Arg Ala Glu Ala Gly Leu Ser Gly Leu 
    370                 375                 380                 


Arg Gly Gly Ala Ala Glu Ala Arg Leu Thr Val Asn Ala Pro Pro Val 
385                 390                 395                 400 


Val Thr Ala Leu His Ser Ala Pro Ala Phe Leu Arg Gly Pro Ala Arg 
                405                 410                 415     


Leu Gln Cys Leu Val Phe Ala Ser Pro Ala Pro Asp Ala Val Val Trp 
            420                 425                 430         


Ser Trp Asp Glu Gly Phe Leu Glu Ala Gly Ser Gln Gly Arg Phe Leu 
        435                 440                 445             


Val Glu Thr Phe Pro Ala Pro Glu Ser Arg Gly Gly Leu Gly Pro Gly 
    450                 455                 460                 


Leu Ile Ser Val Leu His Ile Ser Gly Thr Gln Glu Ser Asp Phe Ser 
465                 470                 475                 480 


Arg Ser Phe Asn Cys Ser Ala Arg Asn Arg Leu Gly Glu Gly Gly Ala 
                485                 490                 495     


Gln Ala Ser Leu Gly Arg Arg Asp Leu Leu Pro Thr Val Arg Ile Val 
            500                 505                 510         


Ala Gly Val Ala Ala Ala Thr Thr Thr Leu Leu Met Val Ile Thr Gly 
        515                 520                 525             


Val Ala Leu Cys Cys Trp Arg His Ser Lys Ala Ser Ala Ser Phe Ser 
    530                 535                 540                 


Glu Gln Lys Asn Leu Met Arg Ile Pro Gly Ser Ser Asp Gly Ser Ser 
545                 550                 555                 560 


Ser Arg Gly Pro Glu Glu Glu Glu Thr Gly Ser Arg Glu Asp Arg Gly 
                565                 570                 575     


Pro Ile Val His Thr Asp His Ser Asp Leu Val Leu Glu Glu Glu Gly 
            580                 585                 590         


Thr Leu Glu Thr Lys Asp Pro Thr Asn Gly Tyr Tyr Lys Val Arg Gly 
        595                 600                 605             


Val Ser Pro Pro Ala Ser Pro Asp Ser Arg Val Thr Ser Phe Gln Trp 
    610                 615                 620                 


Lys Ser Pro Gly Ile Ser Asn Leu Pro 
625                 630             


<210>  7476
<211>  708
<212>  PRT
<213>  Homo Sapiens

<400>  7476

Met Leu Arg Met Arg Val Pro Ala Leu Leu Val Leu Leu Phe Cys Phe 
1               5                   10                  15      


Arg Gly Arg Ala Gly Pro Ser Pro His Phe Leu Gln Gln Pro Glu Asp 
            20                  25                  30          


Leu Val Val Leu Leu Gly Glu Glu Ala Arg Leu Pro Cys Ala Leu Gly 
        35                  40                  45              


Ala Tyr Trp Gly Leu Val Gln Trp Thr Lys Ser Gly Leu Ala Leu Gly 
    50                  55                  60                  


Gly Gln Arg Asp Leu Pro Gly Trp Ser Arg Tyr Trp Ile Ser Gly Asn 
65                  70                  75                  80  


Ala Ala Asn Gly Gln His Asp Leu His Ile Arg Pro Val Glu Leu Glu 
                85                  90                  95      


Asp Glu Ala Ser Tyr Glu Cys Gln Ala Thr Gln Ala Gly Leu Arg Ser 
            100                 105                 110         


Arg Pro Ala Gln Leu His Val Leu Val Pro Pro Glu Ala Pro Gln Val 
        115                 120                 125             


Leu Gly Gly Pro Ser Val Ser Leu Val Ala Gly Val Pro Ala Asn Leu 
    130                 135                 140                 


Thr Cys Arg Ser Arg Gly Asp Ala Arg Pro Thr Pro Glu Leu Leu Trp 
145                 150                 155                 160 


Phe Arg Asp Gly Val Leu Leu Asp Gly Ala Thr Phe His Gln Thr Leu 
                165                 170                 175     


Leu Lys Glu Gly Thr Pro Gly Ser Val Glu Ser Thr Leu Thr Leu Thr 
            180                 185                 190         


Pro Phe Ser His Asp Asp Gly Ala Thr Phe Val Cys Arg Ala Arg Ser 
        195                 200                 205             


Gln Ala Leu Pro Thr Gly Arg Asp Thr Ala Ile Thr Leu Ser Leu Gln 
    210                 215                 220                 


Tyr Pro Pro Glu Val Thr Leu Ser Ala Ser Pro His Thr Val Gln Glu 
225                 230                 235                 240 


Gly Glu Lys Val Ile Phe Leu Cys Gln Ala Thr Ala Gln Pro Pro Val 
                245                 250                 255     


Thr Gly Tyr Arg Trp Ala Lys Gly Gly Ser Pro Val Leu Gly Ala Arg 
            260                 265                 270         


Gly Pro Arg Leu Glu Val Val Ala Asp Ala Ser Phe Leu Thr Glu Pro 
        275                 280                 285             


Val Ser Cys Glu Val Ser Asn Ala Val Gly Ser Ala Asn Arg Ser Thr 
    290                 295                 300                 


Ala Leu Asp Val Leu Phe Gly Pro Ile Leu Gln Ala Lys Pro Glu Pro 
305                 310                 315                 320 


Val Ser Val Asp Val Gly Glu Asp Ala Ser Phe Ser Cys Ala Trp Arg 
                325                 330                 335     


Gly Asn Pro Leu Pro Arg Val Thr Trp Thr Arg Arg Gly Gly Ala Gln 
            340                 345                 350         


Val Leu Gly Ser Gly Ala Thr Leu Arg Leu Pro Ser Val Gly Pro Glu 
        355                 360                 365             


Asp Ala Gly Asp Tyr Val Cys Arg Ala Glu Ala Gly Leu Ser Gly Leu 
    370                 375                 380                 


Arg Gly Gly Ala Ala Glu Ala Arg Leu Thr Val Asn Ala Pro Pro Val 
385                 390                 395                 400 


Val Thr Ala Leu His Ser Ala Pro Ala Phe Leu Arg Gly Pro Ala Arg 
                405                 410                 415     


Leu Gln Cys Leu Val Phe Ala Ser Pro Ala Pro Asp Ala Val Val Trp 
            420                 425                 430         


Ser Trp Asp Glu Gly Phe Leu Glu Ala Gly Ser Gln Gly Arg Phe Leu 
        435                 440                 445             


Val Glu Thr Phe Pro Ala Pro Glu Ser Arg Gly Gly Leu Gly Pro Gly 
    450                 455                 460                 


Leu Ile Ser Val Leu His Ile Ser Gly Thr Gln Glu Ser Asp Phe Ser 
465                 470                 475                 480 


Arg Ser Phe Asn Cys Ser Ala Arg Asn Arg Leu Gly Glu Gly Gly Ala 
                485                 490                 495     


Gln Ala Ser Leu Gly Arg Arg Asp Leu Leu Pro Thr Val Arg Ile Val 
            500                 505                 510         


Ala Gly Val Ala Ala Ala Thr Thr Thr Leu Leu Met Val Ile Thr Gly 
        515                 520                 525             


Val Ala Leu Cys Cys Trp Arg His Ser Lys Ala Ser Ala Ser Phe Ser 
    530                 535                 540                 


Glu Gln Lys Asn Leu Met Arg Ile Pro Gly Ser Ser Asp Gly Ser Ser 
545                 550                 555                 560 


Ser Arg Gly Pro Glu Glu Glu Glu Thr Gly Ser Arg Glu Asp Arg Gly 
                565                 570                 575     


Pro Ile Val His Thr Asp His Ser Asp Leu Val Leu Glu Glu Glu Gly 
            580                 585                 590         


Thr Leu Glu Thr Lys Asp Pro Thr Asn Gly Tyr Tyr Lys Val Arg Gly 
        595                 600                 605             


Val Ser Val Ser Leu Ser Leu Gly Glu Ala Pro Gly Gly Gly Leu Phe 
    610                 615                 620                 


Leu Pro Pro Pro Ser Pro Leu Gly Pro Pro Gly Thr Pro Thr Phe Tyr 
625                 630                 635                 640 


Asp Phe Asn Pro His Leu Gly Met Val Pro Pro Cys Arg Leu Tyr Arg 
                645                 650                 655     


Ala Arg Ala Gly Tyr Leu Thr Thr Pro His Pro Arg Ala Phe Thr Ser 
            660                 665                 670         


Tyr Ile Lys Pro Thr Ser Phe Gly Pro Pro Asp Leu Ala Pro Gly Thr 
        675                 680                 685             


Pro Pro Phe Pro Tyr Ala Ala Phe Pro Thr Pro Ser His Pro Arg Leu 
    690                 695                 700                 


Gln Thr His Val 
705             


<210>  7477
<211>  673
<212>  PRT
<213>  Homo Sapiens

<400>  7477

Met Leu Arg Met Arg Val Pro Ala Leu Leu Val Leu Leu Phe Cys Phe 
1               5                   10                  15      


Arg Gly Arg Ala Gly Pro Ser Pro His Phe Leu Gln Gln Pro Glu Asp 
            20                  25                  30          


Leu Val Val Leu Leu Gly Glu Glu Ala Arg Leu Pro Cys Ala Leu Gly 
        35                  40                  45              


Ala Tyr Trp Gly Leu Val Gln Trp Thr Lys Ser Gly Leu Ala Leu Gly 
    50                  55                  60                  


Gly Gln Arg Asp Leu Pro Gly Trp Ser Arg Tyr Trp Ile Ser Gly Asn 
65                  70                  75                  80  


Ala Ala Asn Gly Gln His Asp Leu His Ile Arg Pro Val Glu Leu Glu 
                85                  90                  95      


Asp Glu Ala Ser Tyr Glu Cys Gln Ala Thr Gln Ala Gly Leu Arg Ser 
            100                 105                 110         


Arg Pro Ala Gln Leu His Val Leu Val Pro Pro Glu Ala Pro Gln Val 
        115                 120                 125             


Leu Gly Gly Pro Ser Val Ser Leu Val Ala Gly Val Pro Ala Asn Leu 
    130                 135                 140                 


Thr Cys Arg Ser Arg Gly Asp Ala Arg Pro Thr Pro Glu Leu Leu Trp 
145                 150                 155                 160 


Phe Arg Asp Gly Val Leu Leu Asp Gly Ala Thr Phe His Gln Thr Leu 
                165                 170                 175     


Leu Lys Glu Gly Thr Pro Gly Ser Val Glu Ser Thr Leu Thr Leu Thr 
            180                 185                 190         


Pro Phe Ser His Asp Asp Gly Ala Thr Phe Val Cys Arg Ala Arg Ser 
        195                 200                 205             


Gln Ala Leu Pro Thr Gly Arg Asp Thr Ala Ile Thr Leu Ser Leu Gln 
    210                 215                 220                 


Tyr Pro Pro Glu Val Thr Leu Ser Ala Ser Pro His Thr Val Gln Glu 
225                 230                 235                 240 


Gly Glu Lys Val Ile Phe Leu Cys Gln Ala Thr Ala Gln Pro Pro Val 
                245                 250                 255     


Thr Gly Tyr Arg Trp Ala Lys Gly Gly Ser Pro Val Leu Gly Ala Arg 
            260                 265                 270         


Gly Pro Arg Leu Glu Val Val Ala Asp Ala Ser Phe Leu Thr Glu Pro 
        275                 280                 285             


Val Ser Cys Glu Val Ser Asn Ala Val Gly Ser Ala Asn Arg Ser Thr 
    290                 295                 300                 


Ala Leu Asp Val Leu Phe Gly Pro Ile Leu Gln Ala Lys Pro Glu Pro 
305                 310                 315                 320 


Val Ser Val Asp Val Gly Glu Asp Ala Ser Phe Ser Cys Ala Trp Arg 
                325                 330                 335     


Gly Asn Pro Leu Pro Arg Val Thr Trp Thr Arg Arg Gly Gly Ala Gln 
            340                 345                 350         


Val Leu Gly Ser Gly Ala Thr Leu Arg Leu Pro Ser Val Gly Pro Glu 
        355                 360                 365             


Asp Ala Gly Asp Tyr Val Cys Arg Ala Glu Ala Gly Leu Ser Gly Leu 
    370                 375                 380                 


Arg Gly Gly Ala Ala Glu Ala Arg Leu Thr Val Asn Ala Pro Pro Val 
385                 390                 395                 400 


Val Thr Ala Leu His Ser Ala Pro Ala Phe Leu Arg Gly Pro Ala Arg 
                405                 410                 415     


Leu Gln Cys Leu Val Phe Ala Ser Pro Ala Pro Asp Ala Val Val Trp 
            420                 425                 430         


Ser Trp Asp Glu Gly Phe Leu Glu Ala Gly Ser Gln Gly Arg Phe Leu 
        435                 440                 445             


Val Glu Thr Phe Pro Ala Pro Glu Ser Arg Gly Gly Leu Gly Pro Gly 
    450                 455                 460                 


Leu Ile Ser Val Leu His Ile Ser Gly Thr Gln Glu Ser Asp Phe Ser 
465                 470                 475                 480 


Arg Ser Phe Asn Cys Ser Ala Arg Asn Arg Leu Gly Glu Gly Gly Ala 
                485                 490                 495     


Gln Ala Ser Leu Gly Arg Arg Ala Ser Ala Ser Phe Ser Glu Gln Lys 
            500                 505                 510         


Asn Leu Met Arg Ile Pro Gly Ser Ser Asp Gly Ser Ser Ser Arg Gly 
        515                 520                 525             


Pro Glu Glu Glu Glu Thr Gly Ser Arg Glu Asp Arg Gly Pro Ile Val 
    530                 535                 540                 


His Thr Asp His Ser Asp Leu Val Leu Glu Glu Glu Gly Thr Leu Glu 
545                 550                 555                 560 


Thr Lys Asp Pro Thr Asn Gly Tyr Tyr Lys Val Arg Gly Val Ser Val 
                565                 570                 575     


Ser Leu Ser Leu Gly Glu Ala Pro Gly Gly Gly Leu Phe Leu Pro Pro 
            580                 585                 590         


Pro Ser Pro Leu Gly Pro Pro Gly Thr Pro Thr Phe Tyr Asp Phe Asn 
        595                 600                 605             


Pro His Leu Gly Met Val Pro Pro Cys Arg Leu Tyr Arg Ala Arg Ala 
    610                 615                 620                 


Gly Tyr Leu Thr Thr Pro His Pro Arg Ala Phe Thr Ser Tyr Ile Lys 
625                 630                 635                 640 


Pro Thr Ser Phe Gly Pro Pro Asp Leu Ala Pro Gly Thr Pro Pro Phe 
                645                 650                 655     


Pro Tyr Ala Ala Phe Pro Thr Pro Ser His Pro Arg Leu Gln Thr His 
            660                 665                 670         


Val 
    


<210>  7478
<211>  583
<212>  PRT
<213>  Homo Sapiens

<400>  7478

Met Leu Arg Met Arg Val Pro Ala Leu Leu Val Leu Leu Phe Cys Phe 
1               5                   10                  15      


Arg Gly Arg Ala Gly Trp Ser Arg Tyr Trp Ile Ser Gly Asn Ala Ala 
            20                  25                  30          


Asn Gly Gln His Asp Leu His Ile Arg Pro Val Glu Leu Glu Asp Glu 
        35                  40                  45              


Ala Ser Tyr Glu Cys Gln Ala Thr Gln Ala Gly Leu Arg Ser Arg Pro 
    50                  55                  60                  


Ala Gln Leu His Val Leu Val Pro Pro Glu Ala Pro Gln Val Leu Gly 
65                  70                  75                  80  


Gly Pro Ser Val Ser Leu Val Ala Gly Val Pro Ala Asn Leu Thr Cys 
                85                  90                  95      


Arg Ser Arg Gly Asp Ala Arg Pro Thr Pro Glu Leu Leu Trp Phe Arg 
            100                 105                 110         


Asp Gly Val Leu Leu Asp Gly Ala Thr Phe His Gln Thr Leu Leu Lys 
        115                 120                 125             


Glu Gly Thr Pro Gly Ser Val Glu Ser Thr Leu Thr Leu Thr Pro Phe 
    130                 135                 140                 


Ser His Asp Asp Gly Ala Thr Phe Val Cys Arg Ala Arg Ser Gln Ala 
145                 150                 155                 160 


Leu Pro Thr Gly Arg Asp Thr Ala Ile Thr Leu Ser Leu Gln Tyr Pro 
                165                 170                 175     


Pro Glu Val Thr Leu Ser Ala Ser Pro His Thr Val Gln Glu Gly Glu 
            180                 185                 190         


Lys Val Ile Phe Leu Cys Gln Ala Thr Ala Gln Pro Pro Val Thr Gly 
        195                 200                 205             


Tyr Arg Trp Ala Lys Gly Gly Ser Pro Val Leu Gly Ala Arg Gly Pro 
    210                 215                 220                 


Arg Leu Glu Val Val Ala Asp Ala Ser Phe Leu Thr Glu Pro Val Ser 
225                 230                 235                 240 


Cys Glu Val Ser Asn Ala Val Gly Ser Ala Asn Arg Ser Thr Ala Leu 
                245                 250                 255     


Asp Val Leu Phe Gly Pro Ile Leu Gln Ala Lys Pro Glu Pro Val Ser 
            260                 265                 270         


Val Asp Val Gly Glu Asp Ala Ser Phe Ser Cys Ala Trp Arg Gly Asn 
        275                 280                 285             


Pro Leu Pro Arg Val Thr Trp Thr Arg Arg Gly Gly Ala Gln Val Leu 
    290                 295                 300                 


Gly Ser Gly Ala Thr Leu Arg Leu Pro Ser Val Gly Pro Glu Asp Ala 
305                 310                 315                 320 


Gly Asp Tyr Val Cys Arg Ala Glu Ala Gly Leu Ser Gly Leu Arg Gly 
                325                 330                 335     


Gly Ala Ala Glu Ala Arg Leu Thr Val Asn Ala Pro Pro Val Val Thr 
            340                 345                 350         


Ala Leu His Ser Ala Pro Ala Phe Leu Arg Gly Pro Ala Arg Leu Gln 
        355                 360                 365             


Cys Leu Val Phe Ala Ser Pro Ala Pro Asp Ala Val Val Trp Ser Trp 
    370                 375                 380                 


Asp Glu Gly Phe Leu Glu Ala Gly Ser Gln Gly Arg Phe Leu Val Glu 
385                 390                 395                 400 


Thr Phe Pro Ala Pro Glu Ser Arg Gly Gly Leu Gly Pro Gly Leu Ile 
                405                 410                 415     


Ser Val Leu His Ile Ser Gly Thr Gln Glu Ser Asp Phe Ser Arg Ser 
            420                 425                 430         


Phe Asn Cys Ser Ala Arg Asn Arg Leu Gly Glu Gly Gly Ala Gln Ala 
        435                 440                 445             


Ser Leu Gly Arg Arg Asp Leu Leu Pro Thr Val Arg Ile Val Ala Gly 
    450                 455                 460                 


Val Ala Ala Ala Thr Thr Thr Leu Leu Met Val Ile Thr Gly Val Ala 
465                 470                 475                 480 


Leu Cys Cys Trp Arg His Ser Lys Ala Ser Ala Ser Phe Ser Glu Gln 
                485                 490                 495     


Lys Asn Leu Met Arg Ile Pro Gly Ser Ser Asp Gly Ser Ser Ser Arg 
            500                 505                 510         


Gly Pro Glu Glu Glu Glu Thr Gly Ser Arg Glu Asp Arg Gly Pro Ile 
        515                 520                 525             


Val His Thr Asp His Ser Asp Leu Val Leu Glu Glu Glu Gly Thr Leu 
    530                 535                 540                 


Glu Thr Lys Asp Pro Thr Asn Gly Tyr Tyr Lys Val Arg Gly Val Ser 
545                 550                 555                 560 


Pro Pro Ala Ser Pro Asp Ser Arg Val Thr Ser Phe Gln Trp Lys Ser 
                565                 570                 575     


Pro Gly Ile Ser Asn Leu Pro 
            580             


<210>  7479
<211>  138
<212>  PRT
<213>  Homo Sapiens

<400>  7479

Met Asn Ser Leu Val Ser Trp Gln Leu Leu Leu Phe Leu Cys Ala Thr 
1               5                   10                  15      


His Phe Gly Glu Pro Leu Glu Lys Val Ala Ser Val Gly Asn Ser Arg 
            20                  25                  30          


Pro Thr Gly Gln Gln Leu Glu Ser Leu Gly Leu Leu Ala Pro Gly Glu 
        35                  40                  45              


Gln Ser Leu Pro Cys Thr Glu Arg Lys Pro Ala Ala Thr Ala Arg Leu 
    50                  55                  60                  


Ser Arg Arg Gly Thr Ser Leu Ser Pro Pro Pro Glu Ser Ser Gly Ser 
65                  70                  75                  80  


Pro Gln Gln Pro Gly Leu Ser Ala Pro His Ser Arg Gln Ile Pro Ala 
                85                  90                  95      


Pro Gln Gly Ala Val Leu Val Gln Arg Glu Lys Asp Leu Pro Asn Tyr 
            100                 105                 110         


Asn Trp Asn Ser Phe Gly Leu Arg Phe Gly Lys Arg Glu Ala Ala Pro 
        115                 120                 125             


Gly Asn His Gly Arg Ser Ala Gly Arg Gly 
    130                 135             


<210>  7480
<211>  144
<212>  PRT
<213>  Homo Sapiens

<400>  7480

Met Asn Ser Leu Val Ser Trp Gln Leu Leu Leu Phe Leu Cys Ala Thr 
1               5                   10                  15      


His Phe Gly Glu Pro Leu Glu Lys Val Ala Ser Val Gly Asn Ser Arg 
            20                  25                  30          


Pro Thr Gly Gln Gln Leu Glu Ser Leu Gly Leu Leu Ala Pro Gly Glu 
        35                  40                  45              


Gln Ser Leu Pro Cys Thr Glu Arg Lys Pro Ala Ala Thr Ala Arg Leu 
    50                  55                  60                  


Ser Arg Arg Gly Thr Ser Leu Ser Pro Pro Pro Glu Ser Ser Gly Ser 
65                  70                  75                  80  


Pro Gln Gln Pro Gly Leu Ser Ala Pro His Ser Arg Gln Ile Pro Ala 
                85                  90                  95      


Pro Gln Gly Ala Val Leu Val Gln Arg Glu Lys Asp Leu Pro Asn Tyr 
            100                 105                 110         


Asn Trp Asn Ser Phe Gly Leu Arg Phe Gly Lys Arg Glu Ala Ala Pro 
        115                 120                 125             


Gly Asn His Gly Arg Ser Ala Gly Arg Gly Gly Ala Gly Ala Gly Gln 
    130                 135                 140                 


<210>  7481
<211>  708
<212>  PRT
<213>  Homo Sapiens

<400>  7481

Met Ala Ala Ala Ala Val Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ser Leu Gln Val Leu Glu Met Glu Ser Met Glu Thr Ala Ala Ala Gly 
            20                  25                  30          


Ser Ala Gly Leu Ala Ala Glu Val Arg Gly Ser Gly Thr Val Asp Phe 
        35                  40                  45              


Gly Pro Gly Pro Gly Ile Ser Ala Met Glu Ala Ser Gly Gly Asp Pro 
    50                  55                  60                  


Gly Pro Glu Ala Glu Asp Phe Glu Cys Ser Ser His Cys Ser Glu Leu 
65                  70                  75                  80  


Ser Trp Arg Gln Asn Glu Gln Arg Arg Gln Gly Leu Phe Cys Asp Ile 
                85                  90                  95      


Thr Leu Cys Phe Gly Gly Ala Gly Gly Arg Glu Phe Arg Ala His Arg 
            100                 105                 110         


Ser Val Leu Ala Ala Ala Thr Glu Tyr Phe Thr Pro Leu Leu Ser Gly 
        115                 120                 125             


Gln Phe Ser Glu Ser Arg Ser Gly Arg Val Glu Met Arg Lys Trp Ser 
    130                 135                 140                 


Ser Glu Pro Gly Pro Glu Pro Asp Thr Val Glu Ala Val Ile Glu Tyr 
145                 150                 155                 160 


Met Tyr Thr Gly Arg Ile Arg Val Ser Thr Gly Ser Val His Glu Val 
                165                 170                 175     


Leu Glu Leu Ala Asp Arg Phe Leu Leu Ile Arg Leu Lys Glu Phe Cys 
            180                 185                 190         


Gly Glu Phe Leu Lys Lys Lys Leu His Leu Ser Asn Cys Val Ala Ile 
        195                 200                 205             


His Ser Leu Ala His Met Tyr Thr Leu Ser Gln Leu Ala Leu Lys Ala 
    210                 215                 220                 


Ala Asp Met Ile Arg Arg Asn Phe His Lys Val Ile Gln Asp Glu Glu 
225                 230                 235                 240 


Phe Tyr Thr Leu Pro Phe His Leu Ile Arg Asp Trp Leu Ser Asp Leu 
                245                 250                 255     


Glu Ile Thr Val Asp Ser Glu Glu Val Leu Phe Glu Thr Val Leu Lys 
            260                 265                 270         


Trp Val Gln Arg Asn Ala Glu Glu Arg Glu Arg Tyr Phe Glu Glu Leu 
        275                 280                 285             


Phe Lys Leu Leu Arg Leu Ser Gln Met Lys Pro Thr Tyr Leu Thr Arg 
    290                 295                 300                 


His Val Lys Pro Glu Arg Leu Val Ala Asn Asn Glu Val Cys Val Lys 
305                 310                 315                 320 


Leu Val Ala Asp Ala Val Glu Arg His Ala Leu Arg Ala Glu Asn Ile 
                325                 330                 335     


Gln Ser Gly Thr Cys Gln His Pro Thr Ser His Val Ser Leu Leu Pro 
            340                 345                 350         


Arg Tyr Gly Gln Asn Met Asp Val Ile Met Val Ile Gly Gly Val Ser 
        355                 360                 365             


Glu Gly Gly Asp Tyr Leu Ser Glu Cys Val Gly Tyr Phe Val Asp Glu 
    370                 375                 380                 


Asp Arg Trp Val Asn Leu Pro His Ile His Asn His Leu Asp Gly His 
385                 390                 395                 400 


Ala Val Ala Val Thr Glu Ser Tyr Val Tyr Val Ala Gly Ser Met Glu 
                405                 410                 415     


Pro Gly Phe Ala Lys Thr Val Glu Arg Tyr Asn Pro Asn Leu Asn Thr 
            420                 425                 430         


Trp Glu His Val Cys Ser Leu Met Thr Arg Lys His Ser Phe Gly Leu 
        435                 440                 445             


Thr Glu Val Lys Gly Lys Leu Tyr Ser Ile Gly Gly His Gly Asn Phe 
    450                 455                 460                 


Ser Pro Gly Phe Lys Asp Val Thr Val Tyr Asn Pro Glu Leu Asp Lys 
465                 470                 475                 480 


Trp His Asn Leu Glu Ser Ala Pro Lys Ile Leu Arg Asp Val Lys Ala 
                485                 490                 495     


Leu Ala Ile Glu Asp Arg Phe Val Tyr Ile Ala Ala Arg Thr Pro Val 
            500                 505                 510         


Asp Arg Asp Thr Glu Asp Gly Leu Lys Ala Val Ile Thr Cys Tyr Asp 
        515                 520                 525             


Thr Glu Thr Arg Gln Trp Gln Asp Val Glu Ser Leu Pro Leu Ile Asp 
    530                 535                 540                 


Asn Tyr Cys Phe Phe Gln Met Ser Val Val Asn Ser Asn Phe Tyr Gln 
545                 550                 555                 560 


Thr Ala Ser Cys Cys Pro Lys Ser Tyr Cys Leu Glu Asn Glu Glu Ala 
                565                 570                 575     


Val Arg Lys Ile Ala Ser Gln Val Ser Asp Glu Ile Leu Glu Ser Leu 
            580                 585                 590         


Pro Pro Glu Val Leu Ser Ile Glu Gly Ala Ala Ile Cys Tyr Tyr Lys 
        595                 600                 605             


Asp Asp Val Phe Ile Ile Gly Gly Trp Lys Asn Ser Asp Asp Ile Asp 
    610                 615                 620                 


Lys Gln Tyr Arg Lys Glu Ala Tyr Arg Tyr Cys Ala Glu Arg Lys Arg 
625                 630                 635                 640 


Trp Met Leu Leu Pro Pro Met Pro Gln Pro Arg Cys Arg Ala Thr Ala 
                645                 650                 655     


Cys His Val Arg Ile Pro Tyr Arg Tyr Leu His Gly Thr Gln Arg Tyr 
            660                 665                 670         


Pro Met Pro Gln Asn Leu Met Trp Gln Lys Asp Arg Ile Arg Gln Met 
        675                 680                 685             


Gln Glu Ile His Arg His Ala Leu Asn Met Arg Arg Val Pro Ser Ser 
    690                 695                 700                 


Gln Ile Glu Cys 
705             


<210>  7482
<211>  235
<212>  PRT
<213>  Homo Sapiens

<400>  7482

Met Ala Glu Glu Gln Glu Phe Thr Gln Leu Cys Lys Leu Pro Ala Gln 
1               5                   10                  15      


Pro Ser His Pro His Cys Val Asn Asn Thr Tyr Arg Ser Ala Gln His 
            20                  25                  30          


Ser Gln Ala Leu Leu Arg Gly Leu Leu Ala Leu Arg Asp Ser Gly Ile 
        35                  40                  45              


Leu Phe Asp Val Val Leu Val Val Glu Gly Arg His Ile Glu Ala His 
    50                  55                  60                  


Arg Ile Leu Leu Ala Ala Ser Cys Asp Tyr Phe Arg Gly Met Phe Ala 
65                  70                  75                  80  


Gly Gly Leu Lys Glu Met Glu Gln Glu Glu Val Leu Ile His Gly Val 
                85                  90                  95      


Ser Tyr Asn Ala Met Cys Gln Ile Leu His Phe Ile Tyr Thr Ser Glu 
            100                 105                 110         


Leu Glu Leu Ser Leu Ser Asn Val Gln Glu Thr Leu Val Ala Ala Cys 
        115                 120                 125             


Gln Leu Gln Ile Pro Glu Ile Ile His Phe Cys Cys Asp Phe Leu Met 
    130                 135                 140                 


Ser Trp Val Asp Glu Glu Asn Ile Leu Asp Val Tyr Arg Leu Ala Glu 
145                 150                 155                 160 


Leu Phe Asp Leu Ser Arg Leu Thr Glu Gln Leu Asp Thr Tyr Ile Leu 
                165                 170                 175     


Lys Asn Phe Val Ala Phe Ser Arg Thr Asp Lys Tyr Arg Gln Leu Pro 
            180                 185                 190         


Leu Glu Lys Val Tyr Ser Leu Leu Ser Ser Asn Arg Leu Glu Val Ser 
        195                 200                 205             


Cys Glu Thr Glu Val Tyr Glu Gly Ala Leu Leu Tyr His Tyr Ser Leu 
    210                 215                 220                 


Glu Gln Val Gln Ala Asp Gln Ile Ser Leu His 
225                 230                 235 


<210>  7483
<211>  634
<212>  PRT
<213>  Homo Sapiens

<400>  7483

Met Ala Glu Glu Gln Glu Phe Thr Gln Leu Cys Lys Leu Pro Ala Gln 
1               5                   10                  15      


Pro Ser His Pro His Cys Val Asn Asn Thr Tyr Arg Ser Ala Gln His 
            20                  25                  30          


Ser Gln Ala Leu Leu Arg Gly Leu Leu Ala Leu Arg Asp Ser Gly Ile 
        35                  40                  45              


Leu Phe Asp Val Val Leu Val Val Glu Gly Arg His Ile Glu Ala His 
    50                  55                  60                  


Arg Ile Leu Leu Ala Ala Ser Cys Asp Tyr Phe Arg Gly Met Phe Ala 
65                  70                  75                  80  


Gly Gly Leu Lys Glu Met Glu Gln Glu Glu Val Leu Ile His Gly Val 
                85                  90                  95      


Ser Tyr Asn Ala Met Cys Gln Ile Leu His Phe Ile Tyr Thr Ser Glu 
            100                 105                 110         


Leu Glu Leu Ser Leu Ser Asn Val Gln Glu Thr Leu Val Ala Ala Cys 
        115                 120                 125             


Gln Leu Gln Ile Pro Glu Ile Ile His Phe Cys Cys Asp Phe Leu Met 
    130                 135                 140                 


Ser Trp Val Asp Glu Glu Asn Ile Leu Asp Val Tyr Arg Leu Ala Glu 
145                 150                 155                 160 


Leu Phe Asp Leu Ser Arg Leu Thr Glu Gln Leu Asp Thr Tyr Ile Leu 
                165                 170                 175     


Lys Asn Phe Val Ala Phe Ser Arg Thr Asp Lys Tyr Arg Gln Leu Pro 
            180                 185                 190         


Leu Glu Lys Val Tyr Ser Leu Leu Ser Ser Asn Arg Leu Glu Val Ser 
        195                 200                 205             


Cys Glu Thr Glu Val Tyr Glu Gly Ala Leu Leu Tyr His Tyr Ser Leu 
    210                 215                 220                 


Glu Gln Val Gln Ala Asp Gln Ile Ser Leu His Glu Pro Pro Lys Leu 
225                 230                 235                 240 


Leu Glu Thr Val Arg Phe Pro Leu Met Glu Ala Glu Val Leu Gln Arg 
                245                 250                 255     


Leu His Asp Lys Leu Asp Pro Ser Pro Leu Arg Asp Thr Val Ala Ser 
            260                 265                 270         


Ala Leu Met Tyr His Arg Asn Glu Ser Leu Gln Pro Ser Leu Gln Ser 
        275                 280                 285             


Pro Gln Thr Glu Leu Arg Ser Asp Phe Gln Cys Val Val Gly Phe Gly 
    290                 295                 300                 


Gly Ile His Ser Thr Pro Ser Thr Val Leu Ser Asp Gln Ala Lys Tyr 
305                 310                 315                 320 


Leu Asn Pro Leu Leu Gly Glu Trp Lys His Phe Thr Ala Ser Leu Ala 
                325                 330                 335     


Pro Arg Met Ser Asn Gln Gly Ile Ala Val Leu Asn Asn Phe Val Tyr 
            340                 345                 350         


Leu Ile Gly Gly Asp Asn Asn Val Gln Gly Phe Arg Ala Glu Ser Arg 
        355                 360                 365             


Cys Trp Arg Tyr Asp Pro Arg His Asn Arg Trp Phe Gln Ile Gln Ser 
    370                 375                 380                 


Leu Gln Gln Glu His Ala Asp Leu Ser Val Cys Val Val Gly Arg Tyr 
385                 390                 395                 400 


Ile Tyr Ala Val Ala Gly Arg Asp Tyr His Asn Asp Leu Asn Ala Val 
                405                 410                 415     


Glu Arg Tyr Asp Pro Ala Thr Asn Ser Trp Ala Tyr Val Ala Pro Leu 
            420                 425                 430         


Lys Arg Glu Val Tyr Ala His Ala Gly Ala Thr Leu Glu Gly Lys Met 
        435                 440                 445             


Tyr Ile Thr Cys Gly Arg Arg Gly Glu Asp Tyr Leu Lys Glu Thr His 
    450                 455                 460                 


Cys Tyr Asp Pro Gly Ser Asn Thr Trp His Thr Leu Ala Asp Gly Pro 
465                 470                 475                 480 


Val Arg Arg Ala Trp His Gly Met Ala Thr Leu Leu Asn Lys Leu Tyr 
                485                 490                 495     


Val Ile Gly Gly Ser Asn Asn Asp Ala Gly Tyr Arg Arg Asp Val His 
            500                 505                 510         


Gln Val Ala Cys Tyr Ser Cys Thr Ser Gly Gln Trp Ser Ser Val Cys 
        515                 520                 525             


Pro Leu Pro Ala Gly His Gly Glu Pro Gly Ile Ala Val Leu Asp Asn 
    530                 535                 540                 


Arg Ile Tyr Val Leu Gly Gly Arg Ser His Asn Arg Gly Ser Arg Thr 
545                 550                 555                 560 


Gly Tyr Val His Ile Tyr Asp Val Glu Lys Asp Cys Trp Glu Glu Gly 
                565                 570                 575     


Pro Gln Leu Asp Asn Ser Ile Ser Gly Leu Ala Ala Cys Val Leu Thr 
            580                 585                 590         


Leu Pro Arg Ser Leu Leu Leu Glu Pro Pro Arg Gly Thr Pro Asp Arg 
        595                 600                 605             


Ser Gln Ala Asp Pro Asp Phe Ala Ser Glu Val Met Ser Val Ser Asp 
    610                 615                 620                 


Trp Glu Glu Phe Asp Asn Ser Ser Glu Asp 
625                 630                 


<210>  7484
<211>  158
<212>  PRT
<213>  Homo Sapiens

<400>  7484

Met Ala Glu Glu Gln Glu Phe Thr Gln Leu Cys Lys Leu Pro Ala Gln 
1               5                   10                  15      


Pro Ser His Pro His Cys Val Asn Asn Thr Tyr Arg Ser Ala Gln His 
            20                  25                  30          


Ser Gln Ala Leu Leu Arg Gly Leu Leu Ala Leu Arg Asp Ser Gly Ile 
        35                  40                  45              


Leu Phe Asp Val Val Leu Val Val Glu Gly Arg His Ile Glu Ala His 
    50                  55                  60                  


Arg Ile Leu Leu Ala Ala Ser Cys Asp Tyr Phe Arg Gly Met Phe Ala 
65                  70                  75                  80  


Gly Gly Leu Lys Glu Met Glu Gln Glu Glu Val Leu Ile His Gly Val 
                85                  90                  95      


Ser Tyr Asn Ala Met Cys Gln Ile Leu His Phe Ile Tyr Thr Ser Glu 
            100                 105                 110         


Leu Glu Leu Ser Leu Ser Asn Val Gln Glu Thr Leu Val Ala Ala Cys 
        115                 120                 125             


Gln Leu Gln Met Leu Phe Thr Ser Pro Gly Leu Asn Gly Cys His Ser 
    130                 135                 140                 


Leu Cys Arg Ser Gln Lys Leu Ser Ile Ser Ala Val Ile Ser 
145                 150                 155             


<210>  7485
<211>  225
<212>  PRT
<213>  Homo Sapiens

<400>  7485

Met Phe Ala Gly Gly Leu Lys Glu Met Glu Gln Glu Glu Val Leu Ile 
1               5                   10                  15      


His Gly Val Ser Tyr Asn Ala Met Cys Gln Ile Leu His Phe Ile Tyr 
            20                  25                  30          


Thr Ser Glu Leu Glu Leu Ser Leu Ser Asn Val Gln Glu Thr Leu Val 
        35                  40                  45              


Ala Ala Cys Gln Leu Gln Ile Pro Glu Ile Ile His Phe Cys Cys Asp 
    50                  55                  60                  


Phe Leu Met Ser Trp Val Asp Glu Glu Asn Ile Leu Asp Val Tyr Arg 
65                  70                  75                  80  


Leu Ala Glu Leu Phe Asp Leu Ser Arg Leu Thr Glu Gln Leu Asp Thr 
                85                  90                  95      


Tyr Ile Leu Lys Asn Phe Val Ala Phe Ser Arg Thr Asp Lys Tyr Arg 
            100                 105                 110         


Gln Leu Pro Leu Glu Lys Val Tyr Ser Leu Leu Ser Ser Asn Arg Leu 
        115                 120                 125             


Glu Val Ser Cys Glu Thr Glu Val Tyr Glu Gly Ala Leu Leu Tyr His 
    130                 135                 140                 


Tyr Ser Leu Glu Gln Val Gln Ala Asp Gln Ile Ser Leu His Glu Pro 
145                 150                 155                 160 


Pro Lys Leu Leu Glu Thr Val Arg Phe Pro Leu Met Glu Ala Glu Val 
                165                 170                 175     


Leu Gln Arg Leu His Asp Lys Leu Asp Pro Ser Pro Leu Arg Asp Thr 
            180                 185                 190         


Val Ala Ser Ala Leu Met Tyr His Arg Asn Glu Ser Leu Gln Pro Ser 
        195                 200                 205             


Leu Gln Ser Pro Gln Thr Glu Leu Arg Ser Asp Phe Gln Cys Val Val 
    210                 215                 220                 


Gly 
225 


<210>  7486
<211>  252
<212>  PRT
<213>  Homo Sapiens

<400>  7486

Met Gly Leu Gly Ser Ser Cys His Leu Ser Leu Pro Lys Arg Ala Glu 
1               5                   10                  15      


Ala Leu Leu Cys Ser Arg Lys Ala Thr Val Val Arg Asp Leu Val Ala 
            20                  25                  30          


Val Arg Met Ala Glu Glu Gln Glu Phe Thr Gln Leu Cys Lys Leu Pro 
        35                  40                  45              


Ala Gln Pro Ser His Pro His Cys Val Asn Asn Thr Tyr Arg Ser Ala 
    50                  55                  60                  


Gln His Ser Gln Ala Leu Leu Arg Gly Leu Leu Ala Leu Arg Asp Ser 
65                  70                  75                  80  


Gly Ile Leu Phe Asp Val Val Leu Val Val Glu Gly Arg His Ile Glu 
                85                  90                  95      


Ala His Arg Ile Leu Leu Ala Ala Ser Cys Asp Tyr Phe Arg Gly Met 
            100                 105                 110         


Phe Ala Gly Gly Leu Lys Glu Met Glu Gln Glu Glu Val Leu Ile His 
        115                 120                 125             


Gly Val Ser Tyr Asn Ala Met Cys Gln Ile Leu His Phe Ile Tyr Thr 
    130                 135                 140                 


Ser Glu Leu Glu Leu Ser Leu Ser Asn Val Gln Glu Thr Leu Val Ala 
145                 150                 155                 160 


Ala Cys Gln Leu Gln Ile Pro Glu Ile Ile His Phe Cys Cys Asp Phe 
                165                 170                 175     


Leu Met Ser Trp Val Asp Glu Glu Asn Ile Leu Asp Val Tyr Arg Leu 
            180                 185                 190         


Ala Glu Leu Phe Asp Leu Ser Arg Leu Thr Glu Gln Leu Asp Thr Tyr 
        195                 200                 205             


Ile Leu Lys Asn Phe Val Ala Phe Ser Arg Thr Asp Lys Tyr Arg Gln 
    210                 215                 220                 


Leu Pro Leu Glu Lys Val Tyr Ser Leu Leu Ser Ser Asn Arg Leu Glu 
225                 230                 235                 240 


Val Ser Cys Glu Thr Glu Val Tyr Glu Gly Ala Leu 
                245                 250         


<210>  7487
<211>  107
<212>  PRT
<213>  Homo Sapiens

<400>  7487

Met Pro Pro Pro Trp His Pro Pro Pro Arg Leu Leu Ala Val Cys Leu 
1               5                   10                  15      


Leu Thr Thr Thr Gln Ala Thr Val Val Arg Asp Leu Val Ala Val Arg 
            20                  25                  30          


Met Ala Glu Glu Gln Glu Phe Thr Gln Leu Cys Lys Leu Pro Ala Gln 
        35                  40                  45              


Pro Ser His Pro His Cys Val Asn Asn Thr Tyr Arg Ser Ala Gln His 
    50                  55                  60                  


Ser Gln Ala Leu Leu Arg Gly Leu Leu Ala Leu Arg Asp Ser Gly Ile 
65                  70                  75                  80  


Leu Phe Asp Val Val Leu Val Val Glu Gly Arg His Ile Glu Ala His 
                85                  90                  95      


Arg Ile Leu Leu Ala Ala Ser Cys Asp Tyr Phe 
            100                 105         


<210>  7488
<211>  295
<212>  PRT
<213>  Homo Sapiens

<400>  7488

Met Pro Pro Pro Trp His Pro Pro Pro Arg Leu Leu Ala Val Cys Leu 
1               5                   10                  15      


Leu Thr Thr Thr Gln Ala Thr Val Val Arg Asp Leu Val Ala Val Arg 
            20                  25                  30          


Met Ala Glu Glu Gln Glu Phe Thr Gln Leu Cys Lys Leu Pro Ala Gln 
        35                  40                  45              


Pro Ser His Pro His Cys Val Asn Asn Thr Tyr Arg Ser Ala Gln His 
    50                  55                  60                  


Ser Gln Ala Leu Leu Arg Gly Leu Leu Ala Leu Arg Asp Ser Gly Ile 
65                  70                  75                  80  


Leu Phe Asp Val Val Leu Val Val Glu Gly Arg His Ile Glu Ala His 
                85                  90                  95      


Arg Ile Leu Leu Ala Ala Ser Cys Asp Tyr Phe Arg Gly Met Phe Ala 
            100                 105                 110         


Gly Gly Leu Lys Glu Met Glu Gln Glu Glu Val Leu Ile His Gly Val 
        115                 120                 125             


Ser Tyr Asn Ala Met Cys Gln Ile Leu His Phe Ile Tyr Thr Ser Glu 
    130                 135                 140                 


Leu Glu Leu Ser Leu Ser Asn Val Gln Glu Thr Leu Val Ala Ala Cys 
145                 150                 155                 160 


Gln Leu Gln Ile Pro Glu Ile Ile His Phe Cys Cys Asp Phe Leu Met 
                165                 170                 175     


Ser Trp Val Asp Glu Glu Asn Ile Leu Asp Val Tyr Arg Leu Ala Glu 
            180                 185                 190         


Leu Phe Asp Leu Ser Arg Leu Thr Glu Gln Leu Asp Thr Tyr Ile Leu 
        195                 200                 205             


Lys Asn Phe Val Ala Phe Ser Arg Thr Asp Lys Tyr Arg Gln Leu Pro 
    210                 215                 220                 


Leu Glu Lys Val Tyr Ser Leu Leu Ser Ser Asn Arg Leu Glu Val Ser 
225                 230                 235                 240 


Cys Glu Thr Glu Val Tyr Glu Gly Ala Leu Leu Tyr His Tyr Ser Leu 
                245                 250                 255     


Glu Gln Val Gln Ala Asp Gln Ile Ser Leu His Glu Pro Pro Lys Leu 
            260                 265                 270         


Leu Glu Thr Val Arg Phe Pro Leu Met Glu Ala Glu Val Leu Gln Arg 
        275                 280                 285             


Leu His Asp Lys Leu Asp Pro 
    290                 295 


<210>  7489
<211>  56
<212>  PRT
<213>  Homo Sapiens

<400>  7489

Met Trp Phe Leu Val Leu Cys Leu Ala Leu Ser Leu Gly Gly Thr Ala 
1               5                   10                  15      


Leu Val Phe Trp Asn Pro Thr Pro Arg Ile Leu Asn Ala Phe Ser Ala 
            20                  25                  30          


Ser Ala Ser Ala Leu Ala Ser Pro Lys Ile Ala Ser Lys Arg Thr Pro 
        35                  40                  45              


Tyr Pro Ser Ser Thr Leu Arg Pro 
    50                  55      


<210>  7490
<211>  262
<212>  PRT
<213>  Homo Sapiens

<400>  7490

Met Trp Phe Leu Val Leu Cys Leu Ala Leu Ser Leu Gly Gly Thr Gly 
1               5                   10                  15      


Ala Ala Pro Pro Ile Gln Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Gln His Ser Gln Pro Trp Gln Ala Ala Leu Tyr His Phe Ser Thr Phe 
        35                  40                  45              


Gln Cys Gly Gly Ile Leu Val His Arg Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Ser Asp Asn Tyr Gln Leu Trp Leu Gly Arg His Asn Leu 
65                  70                  75                  80  


Phe Asp Asp Glu Asn Thr Ala Gln Phe Val His Val Ser Glu Ser Phe 
                85                  90                  95      


Pro His Pro Gly Phe Asn Met Ser Leu Leu Glu Asn His Thr Arg Gln 
            100                 105                 110         


Ala Asp Glu Asp Tyr Ser His Asp Leu Met Leu Leu Arg Leu Thr Glu 
        115                 120                 125             


Pro Ala Asp Thr Ile Thr Asp Ala Val Lys Val Val Glu Leu Pro Thr 
    130                 135                 140                 


Glu Glu Pro Glu Val Gly Ser Thr Cys Leu Ala Ser Gly Trp Gly Ser 
145                 150                 155                 160 


Ile Glu Pro Glu Asn Phe Ser Phe Pro Asp Asp Leu Gln Cys Val Asp 
                165                 170                 175     


Leu Lys Ile Leu Pro Asn Asp Glu Cys Lys Lys Ala His Val Gln Lys 
            180                 185                 190         


Val Thr Asp Phe Met Leu Cys Val Gly His Leu Glu Gly Gly Lys Asp 
        195                 200                 205             


Thr Cys Val Gly Asp Ser Gly Gly Pro Leu Met Cys Asp Gly Val Leu 
    210                 215                 220                 


Gln Gly Val Thr Ser Trp Gly Tyr Val Pro Cys Gly Thr Pro Asn Lys 
225                 230                 235                 240 


Pro Ser Val Ala Val Arg Val Leu Ser Tyr Val Lys Trp Ile Glu Asp 
                245                 250                 255     


Thr Ile Ala Glu Asn Ser 
            260         


<210>  7491
<211>  143
<212>  PRT
<213>  Homo Sapiens

<400>  7491

Met Arg Ala Pro His Leu His Leu Ser Ala Ala Ser Gly Ala Arg Ala 
1               5                   10                  15      


Leu Ala Lys Leu Leu Pro Leu Leu Met Ala Gln Leu Trp Ala Ala Glu 
            20                  25                  30          


Ala Ala Leu Leu Pro Gln Asn Asp Thr Arg Leu Asp Pro Glu Ala Tyr 
        35                  40                  45              


Gly Ser Pro Cys Ala Arg Gly Ser Gln Pro Trp Gln Val Ser Leu Phe 
    50                  55                  60                  


Asn Gly Leu Ser Phe His Cys Ala Gly Val Leu Val Asp Gln Ser Trp 
65                  70                  75                  80  


Val Leu Thr Ala Ala His Cys Gly Asn Lys Pro Leu Trp Ala Arg Val 
                85                  90                  95      


Gly Asp Asp His Leu Leu Leu Leu Gln Gly Glu Gln Leu Arg Arg Thr 
            100                 105                 110         


Thr Arg Ser Val Val His Pro Lys Tyr His Gln Gly Ser Gly Pro Ile 
        115                 120                 125             


Leu Pro Arg Arg Thr Asp Glu His Asp Leu Met Leu Leu Lys Leu 
    130                 135                 140             


<210>  7492
<211>  276
<212>  PRT
<213>  Homo Sapiens

<400>  7492

Met Arg Ala Pro His Leu His Leu Ser Ala Ala Ser Gly Ala Arg Ala 
1               5                   10                  15      


Leu Ala Lys Leu Leu Pro Leu Leu Met Ala Gln Leu Trp Ala Ala Glu 
            20                  25                  30          


Ala Ala Leu Leu Pro Gln Asn Asp Thr Arg Leu Asp Pro Glu Ala Tyr 
        35                  40                  45              


Gly Ser Pro Cys Ala Arg Gly Ser Gln Pro Trp Gln Val Ser Leu Phe 
    50                  55                  60                  


Asn Gly Leu Ser Phe His Cys Ala Gly Val Leu Val Asp Gln Ser Trp 
65                  70                  75                  80  


Val Leu Thr Ala Ala His Cys Gly Asn Lys Pro Leu Trp Ala Arg Val 
                85                  90                  95      


Gly Asp Asp His Leu Leu Leu Leu Gln Gly Glu Gln Leu Arg Arg Thr 
            100                 105                 110         


Thr Arg Ser Val Val His Pro Lys Tyr His Gln Gly Ser Gly Pro Ile 
        115                 120                 125             


Leu Pro Arg Arg Thr Asp Glu His Asp Leu Met Leu Leu Lys Leu Ala 
    130                 135                 140                 


Arg Pro Val Val Leu Gly Pro Arg Val Arg Ala Leu Gln Leu Pro Tyr 
145                 150                 155                 160 


Arg Cys Ala Gln Pro Gly Asp Gln Cys Gln Val Ala Gly Trp Gly Thr 
                165                 170                 175     


Thr Ala Ala Arg Arg Val Lys Tyr Asn Lys Gly Leu Thr Cys Ser Ser 
            180                 185                 190         


Ile Thr Ile Leu Ser Pro Lys Glu Cys Glu Val Phe Tyr Pro Gly Val 
        195                 200                 205             


Val Thr Asn Asn Met Ile Cys Ala Gly Leu Asp Arg Gly Gln Asp Pro 
    210                 215                 220                 


Cys Gln Ser Asp Ser Gly Gly Pro Leu Val Cys Asp Glu Thr Leu Gln 
225                 230                 235                 240 


Gly Ile Leu Ser Trp Gly Val Tyr Pro Cys Gly Ser Ala Gln His Pro 
                245                 250                 255     


Ala Val Tyr Thr Gln Ile Cys Lys Tyr Met Ser Trp Ile Asn Lys Val 
            260                 265                 270         


Ile Arg Ser Asn 
        275     


<210>  7493
<211>  276
<212>  PRT
<213>  Homo Sapiens

<400>  7493

Met Arg Ala Pro His Leu His Leu Ser Ala Ala Ser Gly Ala Arg Ala 
1               5                   10                  15      


Leu Ala Lys Leu Leu Pro Leu Leu Met Ala Gln Leu Trp Ala Ala Glu 
            20                  25                  30          


Ala Ala Leu Leu Pro Gln Asn Asp Thr Arg Leu Asp Pro Glu Ala Tyr 
        35                  40                  45              


Gly Ser Pro Cys Ala Arg Gly Ser Gln Pro Trp Gln Val Ser Leu Phe 
    50                  55                  60                  


Asn Gly Leu Ser Phe His Cys Ala Gly Val Leu Val Asp Gln Ser Trp 
65                  70                  75                  80  


Val Leu Thr Ala Ala His Cys Gly Asn Lys Pro Leu Trp Ala Arg Val 
                85                  90                  95      


Gly Asp Asp His Leu Leu Leu Leu Gln Gly Glu Gln Leu Arg Arg Thr 
            100                 105                 110         


Thr Arg Ser Val Val His Pro Lys Tyr His Gln Gly Ser Gly Pro Ile 
        115                 120                 125             


Leu Pro Arg Arg Thr Asp Glu His Asp Leu Met Leu Leu Lys Leu Ala 
    130                 135                 140                 


Arg Pro Val Val Leu Gly Pro Arg Val Arg Ala Leu Gln Leu Pro Tyr 
145                 150                 155                 160 


Arg Cys Ala Gln Pro Gly Asp Gln Cys Gln Val Ala Gly Trp Gly Thr 
                165                 170                 175     


Thr Ala Ala Arg Arg Val Lys Tyr Asn Lys Gly Leu Thr Cys Ser Ser 
            180                 185                 190         


Ile Thr Ile Leu Ser Pro Lys Glu Cys Glu Val Phe Tyr Pro Gly Val 
        195                 200                 205             


Val Thr Asn Asn Met Ile Cys Ala Gly Leu Asp Arg Gly Gln Asp Pro 
    210                 215                 220                 


Cys Gln Ser Asp Ser Gly Gly Pro Leu Val Cys Asp Glu Thr Leu Gln 
225                 230                 235                 240 


Gly Ile Leu Ser Trp Gly Val Tyr Pro Cys Gly Ser Ala Gln His Pro 
                245                 250                 255     


Ala Val Tyr Thr Gln Ile Cys Lys Tyr Met Ser Trp Ile Asn Lys Val 
            260                 265                 270         


Ile Arg Ser Asn 
        275     


<210>  7494
<211>  276
<212>  PRT
<213>  Homo Sapiens

<400>  7494

Met Arg Ala Pro His Leu His Leu Ser Ala Ala Ser Gly Ala Arg Ala 
1               5                   10                  15      


Leu Ala Lys Leu Leu Pro Leu Leu Met Ala Gln Leu Trp Ala Ala Glu 
            20                  25                  30          


Ala Ala Leu Leu Pro Gln Asn Asp Thr Arg Leu Asp Pro Glu Ala Tyr 
        35                  40                  45              


Gly Ser Pro Cys Ala Arg Gly Ser Gln Pro Trp Gln Val Ser Leu Phe 
    50                  55                  60                  


Asn Gly Leu Ser Phe His Cys Ala Gly Val Leu Val Asp Gln Ser Trp 
65                  70                  75                  80  


Val Leu Thr Ala Ala His Cys Gly Asn Lys Pro Leu Trp Ala Arg Val 
                85                  90                  95      


Gly Asp Asp His Leu Leu Leu Leu Gln Gly Glu Gln Leu Arg Arg Thr 
            100                 105                 110         


Thr Arg Ser Val Val His Pro Lys Tyr His Gln Gly Ser Gly Pro Ile 
        115                 120                 125             


Leu Pro Arg Arg Thr Asp Glu His Asp Leu Met Leu Leu Lys Leu Ala 
    130                 135                 140                 


Arg Pro Val Val Leu Gly Pro Arg Val Arg Ala Leu Gln Leu Pro Tyr 
145                 150                 155                 160 


Arg Cys Ala Gln Pro Gly Asp Gln Cys Gln Val Ala Gly Trp Gly Thr 
                165                 170                 175     


Thr Ala Ala Arg Arg Val Lys Tyr Asn Lys Gly Leu Thr Cys Ser Ser 
            180                 185                 190         


Ile Thr Ile Leu Ser Pro Lys Glu Cys Glu Val Phe Tyr Pro Gly Val 
        195                 200                 205             


Val Thr Asn Asn Met Ile Cys Ala Gly Leu Asp Arg Gly Gln Asp Pro 
    210                 215                 220                 


Cys Gln Ser Asp Ser Gly Gly Pro Leu Val Cys Asp Glu Thr Leu Gln 
225                 230                 235                 240 


Gly Ile Leu Ser Trp Gly Val Tyr Pro Cys Gly Ser Ala Gln His Pro 
                245                 250                 255     


Ala Val Tyr Thr Gln Ile Cys Lys Tyr Met Ser Trp Ile Asn Lys Val 
            260                 265                 270         


Ile Arg Ser Asn 
        275     


<210>  7495
<211>  43
<212>  PRT
<213>  Homo Sapiens

<400>  7495

Met Thr Thr Cys Cys Phe Phe Arg Glu Ser Ser Ser Ala Gly Pro Leu 
1               5                   10                  15      


Ala Leu Leu Ser Ile Pro Ser Thr Thr Arg Ala Gln Ala Pro Ser Cys 
            20                  25                  30          


Gln Gly Glu Arg Met Ser Thr Ile Ser Cys Cys 
        35                  40              


<210>  7496
<211>  282
<212>  PRT
<213>  Homo Sapiens

<400>  7496

Met Gln Arg Leu Arg Trp Leu Arg Asp Trp Lys Ser Ser Gly Arg Gly 
1               5                   10                  15      


Leu Thr Ala Ala Lys Glu Pro Gly Ala Arg Ser Ser Pro Leu Gln Ala 
            20                  25                  30          


Met Arg Ile Leu Gln Leu Ile Leu Leu Ala Leu Ala Thr Gly Leu Val 
        35                  40                  45              


Gly Gly Glu Thr Arg Ile Ile Lys Gly Phe Glu Cys Lys Pro His Ser 
    50                  55                  60                  


Gln Pro Trp Gln Ala Ala Leu Phe Glu Lys Thr Arg Leu Leu Cys Gly 
65                  70                  75                  80  


Ala Thr Leu Ile Ala Pro Arg Trp Leu Leu Thr Ala Ala His Cys Leu 
                85                  90                  95      


Lys Pro Arg Tyr Ile Val His Leu Gly Gln His Asn Leu Gln Lys Glu 
            100                 105                 110         


Glu Gly Cys Glu Gln Thr Arg Thr Ala Thr Glu Ser Phe Pro His Pro 
        115                 120                 125             


Gly Phe Asn Asn Ser Leu Pro Asn Lys Asp His Arg Asn Asp Ile Met 
    130                 135                 140                 


Leu Val Lys Met Ala Ser Pro Val Ser Ile Thr Trp Ala Val Arg Pro 
145                 150                 155                 160 


Leu Thr Leu Ser Ser Arg Cys Val Thr Ala Gly Thr Ser Cys Leu Ile 
                165                 170                 175     


Ser Gly Trp Gly Ser Thr Ser Ser Pro Gln Leu Arg Leu Pro His Thr 
            180                 185                 190         


Leu Arg Cys Ala Asn Ile Thr Ile Ile Glu His Gln Lys Cys Glu Asn 
        195                 200                 205             


Ala Tyr Pro Gly Asn Ile Thr Asp Thr Met Val Cys Ala Ser Val Gln 
    210                 215                 220                 


Glu Gly Gly Lys Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val 
225                 230                 235                 240 


Cys Asn Gln Ser Leu Gln Gly Ile Ile Ser Trp Gly Gln Asp Pro Cys 
                245                 250                 255     


Ala Ile Thr Arg Lys Pro Gly Val Tyr Thr Lys Val Cys Lys Tyr Val 
            260                 265                 270         


Asp Trp Ile Gln Glu Thr Met Lys Asn Asn 
        275                 280         


<210>  7497
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  7497

Met Gln Arg Leu Arg Trp Leu Arg Asp Trp Lys Ser Ser Gly Arg Gly 
1               5                   10                  15      


Leu Thr Ala Ala Lys Glu Pro Gly Ala Arg Ser Ser Pro Leu Gln Ala 
            20                  25                  30          


Met Arg Ile Leu Gln Leu Ile Leu Leu Ala Leu Ala Thr Gly Leu Val 
        35                  40                  45              


Gly Gly Glu Thr Arg Ile Ile Lys Gly Phe Glu Cys Lys Pro His Ser 
    50                  55                  60                  


Gln Pro Trp Gln Ala Ala Leu Phe Glu Lys Thr Arg Leu Leu Cys Gly 
65                  70                  75                  80  


Ala Thr Leu Ile Ala Pro Arg Trp Leu Leu Thr Ala Ala His Cys Leu 
                85                  90                  95      


Lys Pro Trp Pro Leu His Ser Ser Pro Gly Ala Ala Gln Pro Pro Glu 
            100                 105                 110         


Gly Gly Gly Leu 
        115     


<210>  7498
<211>  68
<212>  PRT
<213>  Homo Sapiens

<400>  7498

Met Arg Ile Leu Gln Leu Ile Leu Leu Ala Leu Ala Thr Gly Leu Val 
1               5                   10                  15      


Gly Gly Glu Thr Arg Ile Ile Lys Gly Phe Glu Cys Lys Pro His Ser 
            20                  25                  30          


Gln Pro Trp Gln Ala Ala Leu Phe Glu Lys Thr Arg Leu Leu Cys Gly 
        35                  40                  45              


Ala Thr Leu Ile Ala Pro Arg Trp Leu Leu Thr Ala Ala His Cys Leu 
    50                  55                  60                  


Lys Pro Arg Tyr 
65              


<210>  7499
<211>  170
<212>  PRT
<213>  Homo Sapiens

<400>  7499

Met Arg Ile Leu Gln Leu Ile Leu Leu Ala Leu Ala Thr Gly Leu Val 
1               5                   10                  15      


Gly Gly Glu Thr Arg Ile Ile Lys Gly Phe Glu Cys Lys Pro His Ser 
            20                  25                  30          


Gln Pro Trp Gln Ala Ala Leu Phe Glu Lys Thr Arg Leu Leu Cys Gly 
        35                  40                  45              


Ala Thr Leu Ile Ala Pro Arg Trp Leu Leu Thr Ala Ala His Cys Leu 
    50                  55                  60                  


Lys Pro Arg Tyr Ile Val His Leu Gly Gln His Asn Leu Gln Lys Glu 
65                  70                  75                  80  


Glu Gly Cys Glu Gln Thr Arg Thr Ala Thr Glu Ser Phe Pro His Pro 
                85                  90                  95      


Gly Phe Asn Asn Ser Leu Pro Asn Lys Asp His Arg Asn Asp Ile Met 
            100                 105                 110         


Leu Val Lys Met Ala Ser Pro Val Ser Ile Thr Trp Ala Val Arg Pro 
        115                 120                 125             


Leu Thr Leu Ser Ser Arg Cys Val Thr Ala Gly Thr Ser Cys Leu Ile 
    130                 135                 140                 


Ser Gly Trp Gly Ser Thr Ser Ser Pro Gln Leu Arg Leu Pro His Thr 
145                 150                 155                 160 


Leu Arg Cys Ala Asn Ile Thr Ile Ile Glu 
                165                 170 


<210>  7500
<211>  250
<212>  PRT
<213>  Homo Sapiens

<400>  7500

Met Arg Ile Leu Gln Leu Ile Leu Leu Ala Leu Ala Thr Gly Leu Val 
1               5                   10                  15      


Gly Gly Glu Thr Arg Ile Ile Lys Gly Phe Glu Cys Lys Pro His Ser 
            20                  25                  30          


Gln Pro Trp Gln Ala Ala Leu Phe Glu Lys Thr Arg Leu Leu Cys Gly 
        35                  40                  45              


Ala Thr Leu Ile Ala Pro Arg Trp Leu Leu Thr Ala Ala His Cys Leu 
    50                  55                  60                  


Lys Pro Arg Tyr Ile Val His Leu Gly Gln His Asn Leu Gln Lys Glu 
65                  70                  75                  80  


Glu Gly Cys Glu Gln Thr Arg Thr Ala Thr Glu Ser Phe Pro His Pro 
                85                  90                  95      


Gly Phe Asn Asn Ser Leu Pro Asn Lys Asp His Arg Asn Asp Ile Met 
            100                 105                 110         


Leu Val Lys Met Ala Ser Pro Val Ser Ile Thr Trp Ala Val Arg Pro 
        115                 120                 125             


Leu Thr Leu Ser Ser Arg Cys Val Thr Ala Gly Thr Ser Cys Leu Ile 
    130                 135                 140                 


Ser Gly Trp Gly Ser Thr Ser Ser Pro Gln Leu Arg Leu Pro His Thr 
145                 150                 155                 160 


Leu Arg Cys Ala Asn Ile Thr Ile Ile Glu His Gln Lys Cys Glu Asn 
                165                 170                 175     


Ala Tyr Pro Gly Asn Ile Thr Asp Thr Met Val Cys Ala Ser Val Gln 
            180                 185                 190         


Glu Gly Gly Lys Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val 
        195                 200                 205             


Cys Asn Gln Ser Leu Gln Gly Ile Ile Ser Trp Gly Gln Asp Pro Cys 
    210                 215                 220                 


Ala Ile Thr Arg Lys Pro Gly Val Tyr Thr Lys Val Cys Lys Tyr Val 
225                 230                 235                 240 


Asp Trp Ile Gln Glu Thr Met Lys Asn Asn 
                245                 250 


<210>  7501
<211>  250
<212>  PRT
<213>  Homo Sapiens

<400>  7501

Met Arg Ile Leu Gln Leu Ile Leu Leu Ala Leu Ala Thr Gly Leu Val 
1               5                   10                  15      


Gly Gly Glu Thr Arg Ile Ile Lys Gly Phe Glu Cys Lys Pro His Ser 
            20                  25                  30          


Gln Pro Trp Gln Ala Ala Leu Phe Glu Lys Thr Arg Leu Leu Cys Gly 
        35                  40                  45              


Ala Thr Leu Ile Ala Pro Arg Trp Leu Leu Thr Ala Ala His Cys Leu 
    50                  55                  60                  


Lys Pro Arg Tyr Ile Val His Leu Gly Gln His Asn Leu Gln Lys Glu 
65                  70                  75                  80  


Glu Gly Cys Glu Gln Thr Arg Thr Ala Thr Glu Ser Phe Pro His Pro 
                85                  90                  95      


Gly Phe Asn Asn Ser Leu Pro Asn Lys Asp His Arg Asn Asp Ile Met 
            100                 105                 110         


Leu Val Lys Met Ala Ser Pro Val Ser Ile Thr Trp Ala Val Arg Pro 
        115                 120                 125             


Leu Thr Leu Ser Ser Arg Cys Val Thr Ala Gly Thr Ser Cys Leu Ile 
    130                 135                 140                 


Ser Gly Trp Gly Ser Thr Ser Ser Pro Gln Leu Arg Leu Pro His Thr 
145                 150                 155                 160 


Leu Arg Cys Ala Asn Ile Thr Ile Ile Glu His Gln Lys Cys Glu Asn 
                165                 170                 175     


Ala Tyr Pro Gly Asn Ile Thr Asp Thr Met Val Cys Ala Ser Val Gln 
            180                 185                 190         


Glu Gly Gly Lys Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val 
        195                 200                 205             


Cys Asn Gln Ser Leu Gln Gly Ile Ile Ser Trp Gly Gln Asp Pro Cys 
    210                 215                 220                 


Ala Ile Thr Arg Lys Pro Gly Val Tyr Thr Lys Val Cys Lys Tyr Val 
225                 230                 235                 240 


Asp Trp Ile Gln Glu Thr Met Lys Asn Asn 
                245                 250 


<210>  7502
<211>  275
<212>  PRT
<213>  Homo Sapiens

<400>  7502

Met Arg Ile Leu Gln Leu Ile Leu Leu Ala Leu Ala Thr Gly Leu Val 
1               5                   10                  15      


Gly Gly Glu Thr Arg Ile Ile Lys Gly Phe Glu Cys Lys Pro His Ser 
            20                  25                  30          


Gln Pro Trp Gln Ala Ala Leu Phe Glu Lys Thr Arg Leu Leu Cys Gly 
        35                  40                  45              


Ala Thr Leu Ile Ala Pro Arg Trp Leu Leu Thr Ala Ala His Cys Leu 
    50                  55                  60                  


Lys Pro Trp Val Ser Leu Thr Ser Pro Thr His Val Ser Pro Asp Leu 
65                  70                  75                  80  


Ser Ser Ser Asn Tyr Cys Leu Ser His Leu Ser Arg Tyr Ile Val His 
                85                  90                  95      


Leu Gly Gln His Asn Leu Gln Lys Glu Glu Gly Cys Glu Gln Thr Arg 
            100                 105                 110         


Thr Ala Thr Glu Ser Phe Pro His Pro Gly Phe Asn Asn Ser Leu Pro 
        115                 120                 125             


Asn Lys Asp His Arg Asn Asp Ile Met Leu Val Lys Met Ala Ser Pro 
    130                 135                 140                 


Val Ser Ile Thr Trp Ala Val Arg Pro Leu Thr Leu Ser Ser Arg Cys 
145                 150                 155                 160 


Val Thr Ala Gly Thr Ser Cys Leu Ile Ser Gly Trp Gly Ser Thr Ser 
                165                 170                 175     


Ser Pro Gln Leu Arg Leu Pro His Thr Leu Arg Cys Ala Asn Ile Thr 
            180                 185                 190         


Ile Ile Glu His Gln Lys Cys Glu Asn Ala Tyr Pro Gly Asn Ile Thr 
        195                 200                 205             


Asp Thr Met Val Cys Ala Ser Val Gln Glu Gly Gly Lys Asp Ser Cys 
    210                 215                 220                 


Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Asn Gln Ser Leu Gln Gly 
225                 230                 235                 240 


Ile Ile Ser Trp Gly Gln Asp Pro Cys Ala Ile Thr Arg Lys Pro Gly 
                245                 250                 255     


Val Tyr Thr Lys Val Cys Lys Tyr Val Asp Trp Ile Gln Glu Thr Met 
            260                 265                 270         


Lys Asn Asn 
        275 


<210>  7503
<211>  109
<212>  PRT
<213>  Homo Sapiens

<400>  7503

Met Arg Ile Leu Gln Leu Ile Leu Leu Ala Leu Ala Thr Val Arg Leu 
1               5                   10                  15      


Pro His Thr Leu Arg Cys Ala Asn Ile Thr Ile Ile Glu His Gln Lys 
            20                  25                  30          


Cys Glu Asn Ala Tyr Pro Gly Asn Ile Thr Asp Thr Met Val Cys Ala 
        35                  40                  45              


Ser Val Gln Glu Gly Gly Lys Asp Ser Cys Gln Gly Asp Ser Gly Gly 
    50                  55                  60                  


Pro Leu Val Cys Asn Gln Ser Leu Gln Gly Ile Ile Ser Trp Gly Gln 
65                  70                  75                  80  


Asp Pro Cys Ala Ile Thr Arg Lys Pro Gly Val Tyr Thr Lys Val Cys 
                85                  90                  95      


Lys Tyr Val Asp Trp Ile Gln Glu Thr Met Lys Asn Asn 
            100                 105                 


<210>  7504
<211>  141
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7504

Xaa Asn Ser Leu Pro Asn Lys Asp His Arg Asn Asp Ile Met Leu Val 
1               5                   10                  15      


Lys Met Ala Ser Pro Val Ser Ile Thr Trp Ala Val Arg Pro Leu Thr 
            20                  25                  30          


Leu Ser Ser Arg Cys Val Thr Ala Gly Thr Ser Cys Leu Ile Ser Gly 
        35                  40                  45              


Trp Gly Ser Thr Ser Ser Pro Gln Leu Arg Leu Pro His Thr Leu Arg 
    50                  55                  60                  


Cys Ala Asn Ile Thr Ile Ile Glu His Gln Lys Cys Glu Asn Ala Tyr 
65                  70                  75                  80  


Pro Gly Asn Ile Thr Asp Thr Met Val Cys Ala Ser Val Gln Glu Gly 
                85                  90                  95      


Gly Lys Asp Ser Cys Gln Ser Leu Gln Gly Ile Ile Ser Trp Gly Gln 
            100                 105                 110         


Asp Pro Cys Ala Ile Thr Arg Lys Pro Gly Val Tyr Thr Lys Val Cys 
        115                 120                 125             


Lys Tyr Val Asp Trp Ile Gln Glu Thr Met Lys Asn Asn 
    130                 135                 140     


<210>  7505
<211>  79
<212>  PRT
<213>  Homo Sapiens

<400>  7505

Met Gly Leu Ser Ile Phe Leu Leu Leu Cys Val Leu Gly Glu Phe Ser 
1               5                   10                  15      


Arg Ser Arg Glu Arg Ala Gly Leu Arg Leu Asp Pro Phe Thr Pro Met 
            20                  25                  30          


Arg Arg Pro His His Pro Pro His Leu Ser Ser Gly Pro Gln Pro Gly 
        35                  40                  45              


Gly Glu Glu Glu Arg Gly Phe Leu Cys Ala Ser Ile Tyr Leu Gln Leu 
    50                  55                  60                  


Ser Gly Ala Gln Pro Gly Ser His Thr Glu Asp Phe Gln Trp His 
65                  70                  75                  


<210>  7506
<211>  79
<212>  PRT
<213>  Homo Sapiens

<400>  7506

Met Gly Leu Ser Ile Phe Leu Leu Leu Cys Val Leu Gly Glu Phe Ser 
1               5                   10                  15      


Arg Ser Arg Glu Arg Ala Gly Leu Arg Leu Asp Pro Phe Thr Pro Met 
            20                  25                  30          


Arg Arg Pro His His Pro Pro His Leu Ser Ser Gly Pro Gln Pro Gly 
        35                  40                  45              


Gly Glu Glu Glu Arg Gly Phe Leu Cys Ala Ser Ile Tyr Leu Gln Leu 
    50                  55                  60                  


Ser Gly Ala Gln Pro Gly Ser His Thr Glu Asp Phe Gln Trp His 
65                  70                  75                  


<210>  7507
<211>  111
<212>  PRT
<213>  Homo Sapiens

<400>  7507

Met Gly Leu Ser Ile Phe Leu Leu Leu Cys Val Leu Gly Leu Ser Gln 
1               5                   10                  15      


Ala Ala Thr Pro Lys Ile Phe Asn Gly Thr Glu Cys Gly Arg Asn Ser 
            20                  25                  30          


Gln Pro Trp Gln Val Gly Leu Phe Glu Gly Thr Ser Leu Arg Cys Gly 
        35                  40                  45              


Gly Val Leu Ile Asp His Arg Trp Val Leu Thr Ala Ala His Cys Ser 
    50                  55                  60                  


Gly Arg Pro Ile Pro Gly Ser Ala Pro Val Pro Gln Pro Leu His Arg 
65                  70                  75                  80  


Leu Pro Cys His Leu Pro Trp Cys Val Ser Arg Glu Asn His Glu Gln 
                85                  90                  95      


His Gly Val Cys Arg Arg Arg Pro Gly Ala Gly Cys Leu Pro Gly 
            100                 105                 110     


<210>  7508
<211>  248
<212>  PRT
<213>  Homo Sapiens

<400>  7508

Met Gly Leu Ser Ile Phe Leu Leu Leu Cys Val Leu Gly Leu Ser Gln 
1               5                   10                  15      


Ala Ala Thr Pro Lys Ile Phe Asn Gly Thr Glu Cys Gly Arg Asn Ser 
            20                  25                  30          


Gln Pro Trp Gln Val Gly Leu Phe Glu Gly Thr Ser Leu Arg Cys Gly 
        35                  40                  45              


Gly Val Leu Ile Asp His Arg Trp Val Leu Thr Ala Ala His Cys Ser 
    50                  55                  60                  


Gly Ser Arg Tyr Trp Val Arg Leu Gly Glu His Ser Leu Ser Gln Leu 
65                  70                  75                  80  


Asp Trp Thr Glu Gln Ile Arg His Ser Gly Phe Ser Val Thr His Pro 
                85                  90                  95      


Gly Tyr Leu Gly Ala Ser Thr Ser His Glu His Asp Leu Arg Leu Leu 
            100                 105                 110         


Arg Leu Arg Leu Pro Val Arg Val Thr Ser Ser Val Gln Pro Leu Pro 
        115                 120                 125             


Leu Pro Asn Asp Cys Ala Thr Ala Gly Thr Glu Cys His Val Ser Gly 
    130                 135                 140                 


Trp Gly Ile Thr Asn His Pro Arg Asn Pro Phe Pro Asp Leu Leu Gln 
145                 150                 155                 160 


Cys Leu Asn Leu Ser Ile Val Ser His Ala Thr Cys His Gly Val Tyr 
                165                 170                 175     


Pro Gly Arg Ile Thr Ser Asn Met Val Cys Ala Gly Gly Val Pro Gly 
            180                 185                 190         


Gln Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Gly Gly 
        195                 200                 205             


Val Leu Gln Gly Leu Val Ser Trp Gly Ser Val Gly Pro Cys Gly Gln 
    210                 215                 220                 


Asp Gly Ile Pro Gly Val Tyr Thr Tyr Ile Cys Lys Tyr Val Asp Trp 
225                 230                 235                 240 


Ile Arg Met Ile Met Arg Asn Asn 
                245             


<210>  7509
<211>  248
<212>  PRT
<213>  Homo Sapiens

<400>  7509

Met Gly Leu Ser Ile Phe Leu Leu Leu Cys Val Leu Gly Leu Ser Gln 
1               5                   10                  15      


Ala Ala Thr Pro Lys Ile Phe Asn Gly Thr Glu Cys Gly Arg Asn Ser 
            20                  25                  30          


Gln Pro Trp Gln Val Gly Leu Phe Glu Gly Thr Ser Leu Arg Cys Gly 
        35                  40                  45              


Gly Val Leu Ile Asp His Arg Trp Val Leu Thr Ala Ala His Cys Ser 
    50                  55                  60                  


Gly Ser Arg Tyr Trp Val Arg Leu Gly Glu His Ser Leu Ser Gln Leu 
65                  70                  75                  80  


Asp Trp Thr Glu Gln Ile Arg His Ser Gly Phe Ser Val Thr His Pro 
                85                  90                  95      


Gly Tyr Leu Gly Ala Ser Thr Ser His Glu His Asp Leu Arg Leu Leu 
            100                 105                 110         


Arg Leu Arg Leu Pro Val Arg Val Thr Ser Ser Val Gln Pro Leu Pro 
        115                 120                 125             


Leu Pro Asn Asp Cys Ala Thr Ala Gly Thr Glu Cys His Val Ser Gly 
    130                 135                 140                 


Trp Gly Ile Thr Asn His Pro Arg Asn Pro Phe Pro Asp Leu Leu Gln 
145                 150                 155                 160 


Cys Leu Asn Leu Ser Ile Val Ser His Ala Thr Cys His Gly Val Tyr 
                165                 170                 175     


Pro Gly Arg Ile Thr Ser Asn Met Val Cys Ala Gly Gly Val Pro Gly 
            180                 185                 190         


Gln Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Gly Gly 
        195                 200                 205             


Val Leu Gln Gly Leu Val Ser Trp Gly Ser Val Gly Pro Cys Gly Gln 
    210                 215                 220                 


Asp Gly Ile Pro Gly Val Tyr Thr Tyr Ile Cys Lys Tyr Val Asp Trp 
225                 230                 235                 240 


Ile Arg Met Ile Met Arg Asn Asn 
                245             


<210>  7510
<211>  254
<212>  PRT
<213>  Homo Sapiens

<400>  7510

Met Gly Leu Ser Ile Phe Leu Leu Leu Cys Val Leu Gly Leu Ser Gln 
1               5                   10                  15      


Ala Ala Thr Pro Lys Ile Phe Asn Gly Thr Glu Cys Gly Arg Asn Ser 
            20                  25                  30          


Gln Pro Trp Gln Val Gly Leu Phe Glu Gly Thr Ser Leu Arg Cys Gly 
        35                  40                  45              


Gly Val Leu Ile Asp His Arg Trp Val Leu Thr Ala Ala His Cys Ser 
    50                  55                  60                  


Gly Ser Arg Tyr Trp Val Arg Leu Gly Glu His Ser Leu Ser Gln Leu 
65                  70                  75                  80  


Asp Trp Thr Glu Gln Ile Arg His Ser Gly Phe Ser Val Thr His Pro 
                85                  90                  95      


Gly Tyr Leu Gly Ala Ser Thr Ser His Glu His Asp Leu Arg Leu Leu 
            100                 105                 110         


Arg Leu Arg Leu Pro Val Arg Val Thr Ser Ser Val Gln Pro Leu Pro 
        115                 120                 125             


Leu Pro Asn Asp Cys Ala Thr Ala Gly Thr Glu Cys His Val Ser Gly 
    130                 135                 140                 


Trp Gly Ile Thr Asn His Pro Arg Asn Pro Phe Pro Asp Leu Leu Gln 
145                 150                 155                 160 


Cys Leu Asn Leu Ser Ile Val Ser His Ala Thr Cys His Gly Val Tyr 
                165                 170                 175     


Pro Gly Arg Ile Thr Ser Asn Met Val Cys Ala Gly Gly Val Pro Gly 
            180                 185                 190         


Gln Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Gly Gly 
        195                 200                 205             


Val Leu Gln Gly Leu Val Ser Trp Gly Ser Val Gly Pro Cys Gly Gln 
    210                 215                 220                 


Asp Gly Ile Pro Gly Val Tyr Thr Tyr Ile Cys Asn Ser Thr Leu Val 
225                 230                 235                 240 


Gly Leu Gly Thr Ser Trp Asn Phe Asn Ser Cys Gln Pro Phe 
                245                 250                 


<210>  7511
<211>  177
<212>  PRT
<213>  Homo Sapiens

<400>  7511

Met Gly Leu Ser Ile Phe Leu Leu Leu Cys Val Leu Gly Leu Ser Gln 
1               5                   10                  15      


Ala Ala Thr Pro Lys Ile Phe Asn Gly Thr Glu Cys Gly Arg Asn Ser 
            20                  25                  30          


Gln Pro Trp Gln Val Gly Leu Phe Glu Gly Thr Ser Leu Arg Cys Gly 
        35                  40                  45              


Gly Val Leu Ile Asp His Arg Trp Val Leu Thr Ala Ala His Cys Ser 
    50                  55                  60                  


Gly Ser Arg Tyr Trp Val Arg Leu Gly Glu His Ser Leu Ser Gln Leu 
65                  70                  75                  80  


Asp Trp Thr Glu Gln Ile Arg His Ser Gly Phe Ser Val Thr His Pro 
                85                  90                  95      


Gly Tyr Leu Gly Ala Ser Thr Ser His Glu His Asp Leu Arg Leu Leu 
            100                 105                 110         


Arg Leu Arg Leu Pro Val Arg Val Thr Ser Ser Val Gln Pro Leu Pro 
        115                 120                 125             


Leu Pro Asn Asp Cys Ala Thr Ala Gly Thr Glu Cys His Val Ser Gly 
    130                 135                 140                 


Trp Gly Ile Thr Asn His Pro Arg Ser Lys Gly Pro Arg Ala Arg Gly 
145                 150                 155                 160 


Gln Gly Ser Gly Trp Val Gln Val Trp Asp Ala Gly Arg Glu Val Glu 
                165                 170                 175     


Ser 
    


<210>  7512
<211>  98
<212>  PRT
<213>  Homo Sapiens

<400>  7512

Met Gly Leu Ile Tyr Lys Cys Leu Pro Glu Lys Val Thr Val Asn Ile 
1               5                   10                  15      


Glu Thr Arg Cys Leu Pro Gly Val Phe Gln Gly Ser Gln His Gln Trp 
            20                  25                  30          


Asp Gln Trp Val Ser Pro Arg Trp Leu His Leu Leu Pro Pro Leu Ser 
        35                  40                  45              


Ala Leu Ala Gly Cys Pro Thr Ser Ala Arg Ala Ala Thr Leu Trp Gly 
    50                  55                  60                  


Ser Pro Gly Pro Pro Gln Met Gly Pro His Cys Arg Thr Leu Ser Lys 
65                  70                  75                  80  


Gly Gly Ala Gln Ser Leu Pro Arg Gln Ala Arg Pro Arg Ala Cys Gly 
                85                  90                  95      


Ser Trp 
        


<210>  7513
<211>  98
<212>  PRT
<213>  Homo Sapiens

<400>  7513

Met Gly Leu Ile Tyr Lys Cys Leu Pro Glu Lys Val Thr Val Asn Ile 
1               5                   10                  15      


Glu Thr Arg Cys Leu Pro Gly Val Phe Gln Gly Ser Gln His Gln Trp 
            20                  25                  30          


Asp Gln Trp Val Ser Pro Arg Trp Leu His Leu Leu Pro Pro Leu Ser 
        35                  40                  45              


Ala Leu Ala Gly Cys Pro Thr Ser Ala Arg Ala Ala Thr Leu Trp Gly 
    50                  55                  60                  


Ser Pro Gly Pro Pro Gln Met Gly Pro His Cys Arg Thr Leu Ser Lys 
65                  70                  75                  80  


Gly Gly Ala Gln Ser Leu Pro Arg Gln Ala Arg Pro Arg Ala Cys Gly 
                85                  90                  95      


Ser Trp 
        


<210>  7514
<211>  93
<212>  PRT
<213>  Homo Sapiens

<400>  7514

Met Trp Pro Leu Ala Leu Val Ile Ala Ser Leu Thr Leu Ala Leu Ser 
1               5                   10                  15      


Gly Gly Glu Asp Phe Lys Glu Pro Ser Gln Gly Pro Arg Asp Val Met 
            20                  25                  30          


Ala Ala Ser Arg Pro Glu Ala Phe Pro Lys Gly Leu Thr Leu Glu Pro 
        35                  40                  45              


Arg Pro Glu Lys Gly Gly Ile Cys Gly Cys Leu Ala Pro Gly Thr Ile 
    50                  55                  60                  


Leu Gly Leu Lys Val Gly Trp Leu Phe Ser Ser Gly Asp Thr Pro Trp 
65                  70                  75                  80  


Ile His Ala Arg Ala Thr Pro Glu Cys His Thr Leu Gly 
                85                  90              


<210>  7515
<211>  93
<212>  PRT
<213>  Homo Sapiens

<400>  7515

Met Trp Pro Leu Ala Leu Val Ile Ala Ser Leu Thr Leu Ala Leu Ser 
1               5                   10                  15      


Gly Gly Glu Asp Phe Lys Glu Pro Ser Gln Gly Pro Arg Asp Val Met 
            20                  25                  30          


Ala Ala Ser Arg Pro Glu Ala Phe Pro Lys Gly Leu Thr Leu Glu Pro 
        35                  40                  45              


Arg Pro Glu Lys Gly Gly Ile Cys Gly Cys Leu Ala Pro Gly Thr Ile 
    50                  55                  60                  


Leu Gly Leu Lys Val Gly Trp Leu Phe Ser Ser Gly Asp Thr Pro Trp 
65                  70                  75                  80  


Ile His Ala Arg Ala Thr Pro Glu Cys His Thr Leu Gly 
                85                  90              


<210>  7516
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  7516

Met Trp Pro Leu Ala Leu Val Ile Ala Ser Leu Thr Leu Ala Leu Ser 
1               5                   10                  15      


Gly Gly Val Ser Gln Glu Ser Ser Lys Val Leu Asn Thr Asn Gly Thr 
            20                  25                  30          


Ser Gly Phe Leu Pro Gly Gly Tyr Thr Cys Phe Pro His Ser Gln Pro 
        35                  40                  45              


Trp Gln Ala Ala Leu Leu Val Gln Gly Arg Leu Leu Cys Gly Gly Val 
    50                  55                  60                  


Leu Val His Pro Lys Trp Val Leu Thr Ala Ala His Cys Leu Lys Glu 
65                  70                  75                  80  


Gly Leu Lys Val Tyr Leu Gly Lys His Ala Leu Gly Arg Val Glu Ala 
                85                  90                  95      


Gly Glu Gln 
            


<210>  7517
<211>  180
<212>  PRT
<213>  Homo Sapiens

<400>  7517

Met Trp Pro Leu Ala Leu Val Ile Ala Ser Leu Thr Leu Ala Leu Ser 
1               5                   10                  15      


Gly Gly Val Ser Gln Glu Ser Ser Lys Val Leu Asn Thr Asn Gly Thr 
            20                  25                  30          


Ser Gly Phe Leu Pro Gly Gly Tyr Thr Cys Phe Pro His Ser Gln Pro 
        35                  40                  45              


Trp Gln Ala Ala Leu Leu Val Gln Gly Arg Leu Leu Cys Gly Gly Val 
    50                  55                  60                  


Leu Val His Pro Lys Trp Val Leu Thr Ala Ala His Cys Leu Lys Glu 
65                  70                  75                  80  


Gly Leu Lys Val Tyr Leu Gly Lys His Ala Leu Gly Arg Val Glu Ala 
                85                  90                  95      


Gly Glu Gln Val Arg Glu Val Val His Ser Ile Pro His Pro Glu Tyr 
            100                 105                 110         


Arg Arg Ser Pro Thr His Leu Asn His Asp His Asp Ile Met Leu Leu 
        115                 120                 125             


Glu Leu Gln Ser Pro Val Gln Leu Thr Gly Tyr Ile Gln Thr Leu Pro 
    130                 135                 140                 


Leu Ser His Asn Asn Arg Leu Thr Pro Gly Thr Thr Cys Arg Val Ser 
145                 150                 155                 160 


Gly Trp Gly Thr Thr Thr Ser Pro Gln Gly Met His Pro His Arg Trp 
                165                 170                 175     


Pro Glu Ala Pro 
            180 


<210>  7518
<211>  277
<212>  PRT
<213>  Homo Sapiens

<400>  7518

Met Trp Pro Leu Ala Leu Val Ile Ala Ser Leu Thr Leu Ala Leu Ser 
1               5                   10                  15      


Gly Gly Val Ser Gln Glu Ser Ser Lys Val Leu Asn Thr Asn Gly Thr 
            20                  25                  30          


Ser Gly Phe Leu Pro Gly Gly Tyr Thr Cys Phe Pro His Ser Gln Pro 
        35                  40                  45              


Trp Gln Ala Ala Leu Leu Val Gln Gly Arg Leu Leu Cys Gly Gly Val 
    50                  55                  60                  


Leu Val His Pro Lys Trp Val Leu Thr Ala Ala His Cys Leu Lys Glu 
65                  70                  75                  80  


Gly Leu Lys Val Tyr Leu Gly Lys His Ala Leu Gly Arg Val Glu Ala 
                85                  90                  95      


Gly Glu Gln Val Arg Glu Val Val His Ser Ile Pro His Pro Glu Tyr 
            100                 105                 110         


Arg Arg Ser Pro Thr His Leu Asn His Asp His Asp Ile Met Leu Leu 
        115                 120                 125             


Glu Leu Gln Ser Pro Val Gln Leu Thr Gly Tyr Ile Gln Thr Leu Pro 
    130                 135                 140                 


Leu Ser His Asn Asn Arg Leu Thr Pro Gly Thr Thr Cys Arg Val Ser 
145                 150                 155                 160 


Gly Trp Gly Thr Thr Thr Ser Pro Gln Val Asn Tyr Pro Lys Thr Leu 
                165                 170                 175     


Gln Cys Ala Asn Ile Gln Leu Arg Ser Asp Glu Glu Cys Arg Gln Val 
            180                 185                 190         


Tyr Pro Gly Lys Ile Thr Asp Asn Met Leu Cys Ala Gly Thr Lys Glu 
        195                 200                 205             


Gly Gly Lys Asp Ser Cys Glu Gly Asp Ser Gly Gly Pro Leu Val Cys 
    210                 215                 220                 


Asn Arg Thr Leu Tyr Gly Ile Val Ser Trp Gly Asp Phe Pro Cys Gly 
225                 230                 235                 240 


Gln Pro Asp Arg Pro Gly Val Tyr Thr Arg Val Ser Arg Tyr Val Leu 
                245                 250                 255     


Trp Ile Arg Glu Thr Ile Arg Lys Tyr Glu Thr Gln Gln Gln Lys Trp 
            260                 265                 270         


Leu Lys Gly Pro Gln 
        275         


<210>  7519
<211>  204
<212>  PRT
<213>  Homo Sapiens

<400>  7519

Met Trp Pro Leu Ala Leu Val Ile Ala Ser Leu Thr Leu Ala Leu Ser 
1               5                   10                  15      


Gly Gly Val Ser Gln Glu Ser Ser Lys Val Leu Asn Thr Asn Gly Thr 
            20                  25                  30          


Ser Gly Phe Leu Pro Gly Gly Tyr Thr Cys Phe Pro His Ser Gln Pro 
        35                  40                  45              


Trp Gln Ala Ala Leu Leu Val Gln Gly Arg Leu Leu Cys Gly Gly Val 
    50                  55                  60                  


Leu Val His Pro Lys Trp Val Leu Thr Ala Ala His Cys Leu Lys Glu 
65                  70                  75                  80  


Gly Leu Lys Val Tyr Leu Gly Lys His Ala Leu Gly Arg Val Glu Ala 
                85                  90                  95      


Val Asn Tyr Pro Lys Thr Leu Gln Cys Ala Asn Ile Gln Leu Arg Ser 
            100                 105                 110         


Asp Glu Glu Cys Arg Gln Val Tyr Pro Gly Lys Ile Thr Asp Asn Met 
        115                 120                 125             


Leu Cys Ala Gly Thr Lys Glu Gly Gly Lys Asp Ser Cys Glu Gly Asp 
    130                 135                 140                 


Ser Gly Gly Pro Leu Val Cys Asn Arg Thr Leu Tyr Gly Ile Val Ser 
145                 150                 155                 160 


Trp Gly Asp Phe Pro Cys Gly Gln Pro Asp Arg Pro Gly Val Tyr Thr 
                165                 170                 175     


Arg Val Ser Arg Tyr Val Leu Trp Ile Arg Glu Thr Ile Arg Lys Tyr 
            180                 185                 190         


Glu Thr Gln Gln Gln Lys Trp Leu Lys Gly Pro Gln 
        195                 200                 


<210>  7520
<211>  125
<212>  PRT
<213>  Homo Sapiens

<400>  7520

Met Trp Pro Leu Ala Leu Val Ile Ala Ser Leu Thr Leu Ala Leu Ser 
1               5                   10                  15      


Gly Val Asn Tyr Pro Lys Thr Leu Gln Cys Ala Asn Ile Gln Leu Arg 
            20                  25                  30          


Ser Asp Glu Glu Cys Arg Gln Val Tyr Pro Gly Lys Ile Thr Asp Asn 
        35                  40                  45              


Met Leu Cys Ala Gly Thr Lys Glu Gly Gly Lys Asp Ser Cys Glu Gly 
    50                  55                  60                  


Asp Ser Gly Gly Pro Leu Val Cys Asn Arg Thr Leu Tyr Gly Ile Val 
65                  70                  75                  80  


Ser Trp Gly Asp Phe Pro Cys Gly Gln Pro Asp Arg Pro Gly Val Tyr 
                85                  90                  95      


Thr Arg Val Ser Arg Tyr Val Leu Trp Ile Arg Glu Thr Ile Arg Lys 
            100                 105                 110         


Tyr Glu Thr Gln Gln Gln Lys Trp Leu Lys Gly Pro Gln 
        115                 120                 125 


<210>  7521
<211>  267
<212>  PRT
<213>  Homo Sapiens

<400>  7521

Met Ser Leu Arg Val Leu Gly Ser Gly Thr Trp Pro Ser Ala Pro Lys 
1               5                   10                  15      


Met Phe Leu Leu Leu Thr Ala Leu Gln Val Leu Ala Ile Ala Met Thr 
            20                  25                  30          


Gln Ser Gln Glu Asp Glu Asn Lys Ile Ile Gly Gly His Thr Cys Thr 
        35                  40                  45              


Arg Ser Ser Gln Pro Trp Gln Ala Ala Leu Leu Ala Gly Pro Arg Arg 
    50                  55                  60                  


Arg Phe Leu Cys Gly Gly Ala Leu Leu Ser Gly Gln Trp Val Ile Thr 
65                  70                  75                  80  


Ala Ala His Cys Gly Arg Pro Ile Leu Gln Val Ala Leu Gly Lys His 
                85                  90                  95      


Asn Leu Arg Arg Trp Glu Ala Thr Gln Gln Val Leu Arg Val Val Arg 
            100                 105                 110         


Gln Val Thr His Pro Asn Tyr Asn Ser Arg Thr His Asp Asn Asp Leu 
        115                 120                 125             


Met Leu Leu Gln Leu Gln Gln Pro Ala Arg Ile Gly Arg Ala Val Arg 
    130                 135                 140                 


Pro Ile Glu Val Thr Gln Ala Cys Ala Ser Pro Gly Thr Ser Cys Arg 
145                 150                 155                 160 


Val Ser Gly Trp Gly Thr Ile Ser Ser Pro Ile Ala Arg Tyr Pro Ala 
                165                 170                 175     


Ser Leu Gln Cys Val Asn Ile Asn Ile Ser Pro Asp Glu Val Cys Gln 
            180                 185                 190         


Lys Ala Tyr Pro Arg Thr Ile Thr Pro Gly Met Val Cys Ala Gly Val 
        195                 200                 205             


Pro Gln Gly Gly Lys Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu 
    210                 215                 220                 


Val Cys Arg Gly Gln Leu Gln Gly Leu Val Ser Trp Gly Met Glu Arg 
225                 230                 235                 240 


Cys Ala Leu Pro Gly Tyr Pro Gly Val Tyr Thr Asn Leu Cys Lys Tyr 
                245                 250                 255     


Arg Ser Trp Ile Glu Glu Thr Met Arg Asp Lys 
            260                 265         


<210>  7522
<211>  267
<212>  PRT
<213>  Homo Sapiens

<400>  7522

Met Ser Leu Arg Val Leu Gly Ser Gly Thr Trp Pro Ser Ala Pro Lys 
1               5                   10                  15      


Met Phe Leu Leu Leu Thr Ala Leu Gln Val Leu Ala Ile Ala Met Thr 
            20                  25                  30          


Gln Ser Gln Glu Asp Glu Asn Lys Ile Ile Gly Gly His Thr Cys Thr 
        35                  40                  45              


Arg Ser Ser Gln Pro Trp Gln Ala Ala Leu Leu Ala Gly Pro Arg Arg 
    50                  55                  60                  


Arg Phe Leu Cys Gly Gly Ala Leu Leu Ser Gly Gln Trp Val Ile Thr 
65                  70                  75                  80  


Ala Ala His Cys Gly Arg Pro Ile Leu Gln Val Ala Leu Gly Lys His 
                85                  90                  95      


Asn Leu Arg Arg Trp Glu Ala Thr Gln Gln Val Leu Arg Val Val Arg 
            100                 105                 110         


Gln Val Thr His Pro Asn Tyr Asn Ser Arg Thr His Asp Asn Asp Leu 
        115                 120                 125             


Met Leu Leu Gln Leu Gln Gln Pro Ala Arg Ile Gly Arg Ala Val Arg 
    130                 135                 140                 


Pro Ile Glu Val Thr Gln Ala Cys Ala Ser Pro Gly Thr Ser Cys Arg 
145                 150                 155                 160 


Val Ser Gly Trp Gly Thr Ile Ser Ser Pro Ile Ala Arg Tyr Pro Ala 
                165                 170                 175     


Ser Leu Gln Cys Val Asn Ile Asn Ile Ser Pro Asp Glu Val Cys Gln 
            180                 185                 190         


Lys Ala Tyr Pro Arg Thr Ile Thr Pro Gly Met Val Cys Ala Gly Val 
        195                 200                 205             


Pro Gln Gly Gly Lys Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu 
    210                 215                 220                 


Val Cys Arg Gly Gln Leu Gln Gly Leu Val Ser Trp Gly Met Glu Arg 
225                 230                 235                 240 


Cys Ala Leu Pro Gly Tyr Pro Gly Val Tyr Thr Asn Leu Cys Lys Tyr 
                245                 250                 255     


Arg Ser Trp Ile Glu Glu Thr Met Arg Asp Lys 
            260                 265         


<210>  7523
<211>  43
<212>  PRT
<213>  Homo Sapiens

<400>  7523

Met Arg Val Arg Leu Gly Glu His Asn Leu Arg Lys Arg Asp Gly Pro 
1               5                   10                  15      


Glu Gln Leu Arg Thr Thr Ser Arg Val Ile Pro His Pro Arg Tyr Glu 
            20                  25                  30          


Ala Arg Ser His Arg Asn Asp Ile Met Leu Leu 
        35                  40              


<210>  7524
<211>  256
<212>  PRT
<213>  Homo Sapiens

<400>  7524

Met Trp Leu Leu Leu Thr Leu Ser Phe Leu Leu Ala Ser Thr Ala Ala 
1               5                   10                  15      


Gln Asp Gly Asp Lys Leu Leu Glu Gly Asp Glu Cys Ala Pro His Ser 
            20                  25                  30          


Gln Pro Trp Gln Val Ala Leu Tyr Glu Arg Gly Arg Phe Asn Cys Gly 
        35                  40                  45              


Ala Ser Leu Ile Ser Pro His Trp Val Leu Ser Ala Ala His Cys Gln 
    50                  55                  60                  


Ser Arg Phe Met Arg Val Arg Leu Gly Glu His Asn Leu Arg Lys Arg 
65                  70                  75                  80  


Asp Gly Pro Glu Gln Leu Arg Thr Thr Ser Arg Val Ile Pro His Pro 
                85                  90                  95      


Arg Tyr Glu Ala Arg Ser His Arg Asn Asp Ile Met Leu Leu Arg Leu 
            100                 105                 110         


Val Gln Pro Ala Arg Leu Asn Pro Gln Val Arg Pro Ala Val Leu Pro 
        115                 120                 125             


Thr Arg Cys Pro His Pro Gly Glu Ala Cys Val Val Ser Gly Trp Gly 
    130                 135                 140                 


Leu Val Ser His Asn Glu Pro Gly Thr Ala Gly Ser Pro Arg Ser Gln 
145                 150                 155                 160 


Val Ser Leu Pro Asp Thr Leu His Cys Ala Asn Ile Ser Ile Ile Ser 
                165                 170                 175     


Asp Thr Ser Cys Asp Lys Ser Tyr Pro Gly Arg Leu Thr Asn Thr Met 
            180                 185                 190         


Val Cys Ala Gly Ala Glu Gly Arg Gly Ala Glu Ser Cys Glu Gly Asp 
        195                 200                 205             


Ser Gly Gly Pro Leu Val Cys Gly Gly Ile Leu Gln Gly Ile Val Ser 
    210                 215                 220                 


Trp Gly Asp Val Pro Cys Asp Asn Thr Thr Lys Pro Gly Val Tyr Thr 
225                 230                 235                 240 


Lys Val Cys His Tyr Leu Glu Trp Ile Arg Glu Thr Met Lys Arg Asn 
                245                 250                 255     


<210>  7525
<211>  120
<212>  PRT
<213>  Homo Sapiens

<400>  7525

Met Trp Leu Leu Leu Thr Leu Ser Phe Leu Leu Ala Ser Thr Ala Gln 
1               5                   10                  15      


Asp Gly Asp Lys Leu Leu Glu Gly Asp Glu Cys Ala Pro His Ser Gln 
            20                  25                  30          


Pro Trp Gln Val Ala Leu Tyr Glu Arg Gly Arg Phe Asn Cys Gly Ala 
        35                  40                  45              


Ser Leu Ile Ser Pro His Trp Val Leu Ser Ala Ala His Cys Gln Ser 
    50                  55                  60                  


Arg Phe Met Arg Val Arg Leu Gly Glu His Asn Leu Arg Lys Arg Asp 
65                  70                  75                  80  


Gly Pro Glu Gln Leu Arg Thr Thr Ser Arg Val Ile Pro His Pro Arg 
                85                  90                  95      


Tyr Glu Ala Arg Ser His Arg Asn Asp Ile Met Leu Leu Arg Leu Val 
            100                 105                 110         


Gln Pro Ala Arg Leu Asn Pro Gln 
        115                 120 


<210>  7526
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  7526

Met Trp Leu Leu Leu Thr Leu Ser Phe Leu Leu Ala Ser Thr Ala Gln 
1               5                   10                  15      


Asp Gly Asp Lys Leu Leu Glu Gly Asp Glu Cys Ala Pro His Ser Gln 
            20                  25                  30          


Pro Trp Gln Val Ala Leu Tyr Glu Arg Gly Arg Phe Asn Cys Gly Ala 
        35                  40                  45              


Ser Leu Ile Ser Pro His Trp Val Leu Ser Ala Ala His Cys Gln Ser 
    50                  55                  60                  


Arg Phe Met Arg Val Arg Leu Gly Glu His Asn Leu Arg Lys Arg Asp 
65                  70                  75                  80  


Gly Pro Glu Gln Leu Arg Thr Thr Ser Arg Val Ile Pro His Pro Arg 
                85                  90                  95      


Tyr Glu Ala Arg Ser His Arg Asn Asp Ile Met Leu Leu Arg Leu Val 
            100                 105                 110         


Gln Pro Ala Arg Leu Asn Pro Gln Val Arg Pro Ala Val Leu Pro Thr 
        115                 120                 125             


Arg Cys Pro His Pro Gly Glu Ala Cys Val Val Ser Gly Trp Gly Leu 
    130                 135                 140                 


Val Ser His Asn Glu Pro Gly Thr Ala Gly Ser Pro Arg Ser Gln Gly 
145                 150                 155                 160 


<210>  7527
<211>  255
<212>  PRT
<213>  Homo Sapiens

<400>  7527

Met Trp Leu Leu Leu Thr Leu Ser Phe Leu Leu Ala Ser Thr Ala Gln 
1               5                   10                  15      


Asp Gly Asp Lys Leu Leu Glu Gly Asp Glu Cys Ala Pro His Ser Gln 
            20                  25                  30          


Pro Trp Gln Val Ala Leu Tyr Glu Arg Gly Arg Phe Asn Cys Gly Ala 
        35                  40                  45              


Ser Leu Ile Ser Pro His Trp Val Leu Ser Ala Ala His Cys Gln Ser 
    50                  55                  60                  


Arg Phe Met Arg Val Arg Leu Gly Glu His Asn Leu Arg Lys Arg Asp 
65                  70                  75                  80  


Gly Pro Glu Gln Leu Arg Thr Thr Ser Arg Val Ile Pro His Pro Arg 
                85                  90                  95      


Tyr Glu Ala Arg Ser His Arg Asn Asp Ile Met Leu Leu Arg Leu Val 
            100                 105                 110         


Gln Pro Ala Arg Leu Asn Pro Gln Val Arg Pro Ala Val Leu Pro Thr 
        115                 120                 125             


Arg Cys Pro His Pro Gly Glu Ala Cys Val Val Ser Gly Trp Gly Leu 
    130                 135                 140                 


Val Ser His Asn Glu Pro Gly Thr Ala Gly Ser Pro Arg Ser Gln Val 
145                 150                 155                 160 


Ser Leu Pro Asp Thr Leu His Cys Ala Asn Ile Ser Ile Ile Ser Asp 
                165                 170                 175     


Thr Ser Cys Asp Lys Ser Tyr Pro Gly Arg Leu Thr Asn Thr Met Val 
            180                 185                 190         


Cys Ala Gly Ala Glu Gly Arg Gly Ala Glu Ser Cys Glu Gly Asp Ser 
        195                 200                 205             


Gly Gly Pro Leu Val Cys Gly Gly Ile Leu Gln Gly Ile Val Ser Trp 
    210                 215                 220                 


Gly Asp Val Pro Cys Asp Asn Thr Thr Lys Pro Gly Val Tyr Thr Lys 
225                 230                 235                 240 


Val Cys His Tyr Leu Glu Trp Ile Arg Glu Thr Met Lys Arg Asn 
                245                 250                 255 


<210>  7528
<211>  23
<212>  PRT
<213>  Homo Sapiens

<400>  7528

Met Ser Leu Leu Lys His Gln Ser Leu Arg Pro Asp Glu Asp Ser Ser 
1               5                   10                  15      


His Asp Leu Met Leu Leu Arg 
            20              


<210>  7529
<211>  44
<212>  PRT
<213>  Homo Sapiens

<400>  7529

Met Ser Leu Leu Lys His Gln Ser Leu Arg Pro Asp Glu Asp Ser Ser 
1               5                   10                  15      


His Asp Leu Met Leu Leu Arg Leu Ser Glu Pro Ala Lys Ile Thr Asp 
            20                  25                  30          


Val Val Lys Val Leu Gly Leu Pro Thr Gln Glu Pro 
        35                  40                  


<210>  7530
<211>  159
<212>  PRT
<213>  Homo Sapiens

<400>  7530

Met Ser Leu Leu Lys His Gln Ser Leu Arg Pro Asp Glu Asp Ser Ser 
1               5                   10                  15      


His Asp Leu Met Leu Leu Arg Leu Ser Glu Pro Ala Lys Ile Thr Asp 
            20                  25                  30          


Val Val Lys Val Leu Gly Leu Pro Thr Gln Glu Pro Ala Leu Gly Thr 
        35                  40                  45              


Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile Glu Pro Glu Glu Phe Leu 
    50                  55                  60                  


Arg Pro Arg Ser Leu Gln Cys Val Ser Leu His Leu Leu Ser Asn Asp 
65                  70                  75                  80  


Met Cys Ala Arg Ala Tyr Ser Glu Lys Val Thr Glu Phe Met Leu Cys 
                85                  90                  95      


Ala Gly Leu Trp Thr Gly Gly Lys Asp Thr Cys Gly Gly Asp Ser Gly 
            100                 105                 110         


Gly Pro Leu Val Cys Asn Gly Val Leu Gln Gly Ile Thr Ser Trp Gly 
        115                 120                 125             


Pro Glu Pro Cys Ala Leu Pro Glu Lys Pro Ala Val Tyr Thr Lys Val 
    130                 135                 140                 


Val His Tyr Arg Lys Trp Ile Lys Asp Thr Ile Ala Ala Asn Pro 
145                 150                 155                 


<210>  7531
<211>  69
<212>  PRT
<213>  Homo Sapiens

<400>  7531

Met Trp Asp Leu Val Leu Ser Ile Ala Leu Ser Val Gly Cys Thr Gly 
1               5                   10                  15      


Ala Val Pro Leu Ile Gln Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Ala Val Tyr Ser His Gly Trp Ala 
        35                  40                  45              


His Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Leu Lys Lys 
65                  


<210>  7532
<211>  122
<212>  PRT
<213>  Homo Sapiens

<400>  7532

Met Trp Asp Leu Val Leu Ser Ile Ala Leu Ser Val Gly Cys Thr Gly 
1               5                   10                  15      


Ala Val Pro Leu Ile Gln Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Ala Val Tyr Ser His Gly Trp Ala 
        35                  40                  45              


His Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Leu Lys Lys Ala Cys Gln Asp His Arg Cys Cys Glu Gly Pro 
65                  70                  75                  80  


Gly Pro Ala His Pro Gly Ala Ser Thr Gly Asp His Leu Leu Arg Leu 
                85                  90                  95      


Arg Leu Gly Gln His Arg Thr Arg Gly Val Leu Ala Pro Gln Glu Ser 
            100                 105                 110         


Ser Val Cys Glu Pro Pro Ser Pro Val Gln 
        115                 120         


<210>  7533
<211>  164
<212>  PRT
<213>  Homo Sapiens

<400>  7533

Met Trp Asp Leu Val Leu Ser Ile Ala Leu Ser Val Gly Cys Thr Gly 
1               5                   10                  15      


Ala Val Pro Leu Ile Gln Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Ala Val Tyr Ser His Gly Trp Ala 
        35                  40                  45              


His Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Leu Lys Lys Asn Ser Gln Val Trp Leu Gly Arg His Asn Leu 
65                  70                  75                  80  


Phe Glu Pro Glu Asp Thr Gly Gln Arg Val Pro Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asn Met Ser Leu Leu Lys His Gln Ser Leu Arg 
            100                 105                 110         


Pro Asp Glu Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu 
        115                 120                 125             


Pro Ala Lys Ile Thr Asp Val Val Lys Val Leu Gly Leu Pro Thr Gln 
    130                 135                 140                 


Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Glu 
                


<210>  7534
<211>  261
<212>  PRT
<213>  Homo Sapiens

<400>  7534

Met Trp Asp Leu Val Leu Ser Ile Ala Leu Ser Val Gly Cys Thr Gly 
1               5                   10                  15      


Ala Val Pro Leu Ile Gln Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Ala Val Tyr Ser His Gly Trp Ala 
        35                  40                  45              


His Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Leu Lys Lys Asn Ser Gln Val Trp Leu Gly Arg His Asn Leu 
65                  70                  75                  80  


Phe Glu Pro Glu Asp Thr Gly Gln Arg Val Pro Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asn Met Ser Leu Leu Lys His Gln Ser Leu Arg 
            100                 105                 110         


Pro Asp Glu Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu 
        115                 120                 125             


Pro Ala Lys Ile Thr Asp Val Val Lys Val Leu Gly Leu Pro Thr Gln 
    130                 135                 140                 


Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Glu Phe Leu Arg Pro Arg Ser Leu Gln Cys Val Ser Leu 
                165                 170                 175     


His Leu Leu Ser Asn Asp Met Cys Ala Arg Ala Tyr Ser Glu Lys Val 
            180                 185                 190         


Thr Glu Phe Met Leu Cys Ala Gly Leu Trp Thr Gly Gly Lys Asp Thr 
        195                 200                 205             


Cys Gly Gly Asp Ser Gly Gly Pro Leu Val Cys Asn Gly Val Leu Gln 
    210                 215                 220                 


Gly Ile Thr Ser Trp Gly Pro Glu Pro Cys Ala Leu Pro Glu Lys Pro 
225                 230                 235                 240 


Ala Val Tyr Thr Lys Val Val His Tyr Arg Lys Trp Ile Lys Asp Thr 
                245                 250                 255     


Ile Ala Ala Asn Pro 
            260     


<210>  7535
<211>  223
<212>  PRT
<213>  Homo Sapiens

<400>  7535

Met Trp Asp Leu Val Leu Ser Ile Ala Leu Ser Val Gly Cys Thr Gly 
1               5                   10                  15      


Ala Val Pro Leu Ile Gln Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Ala Val Tyr Ser His Gly Trp Ala 
        35                  40                  45              


His Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Leu Lys Lys Asn Ser Gln Val Trp Leu Gly Arg His Asn Leu 
65                  70                  75                  80  


Phe Glu Pro Glu Asp Thr Gly Gln Arg Val Pro Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asn Met Ser Leu Leu Lys His Gln Ser Leu Arg 
            100                 105                 110         


Pro Asp Glu Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu 
        115                 120                 125             


Pro Ala Lys Ile Thr Asp Val Val Lys Val Leu Gly Leu Pro Thr Gln 
    130                 135                 140                 


Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Glu Phe Leu Arg Pro Arg Ser Leu Gln Cys Val Ser Leu 
                165                 170                 175     


His Leu Leu Ser Asn Asp Met Cys Ala Arg Ala Tyr Ser Glu Lys Val 
            180                 185                 190         


Thr Glu Phe Met Leu Cys Ala Gly Leu Trp Thr Gly Gly Lys Asp Thr 
        195                 200                 205             


Cys Gly Val Ser His Pro Tyr Ser Gln His Leu Glu Gly Lys Gly 
    210                 215                 220             


<210>  7536
<211>  49
<212>  PRT
<213>  Homo Sapiens

<400>  7536

Met Trp Asp Leu Val Leu Ser Ile Ala Leu Ser Val Gly Cys Thr Gly 
1               5                   10                  15      


Ile Ala Arg Ser Gly Trp Val Gly Thr Thr Cys Leu Ser Leu Lys Thr 
            20                  25                  30          


Gln Ala Arg Gly Ser Leu Ser Ala Thr Ala Ser His Thr Arg Ser Thr 
        35                  40                  45              


Ile 
    


<210>  7537
<211>  49
<212>  PRT
<213>  Homo Sapiens

<400>  7537

Met Trp Asp Leu Val Leu Ser Ile Ala Leu Ser Val Gly Cys Thr Gly 
1               5                   10                  15      


Ile Ala Arg Ser Gly Trp Val Gly Thr Thr Cys Leu Ser Leu Lys Thr 
            20                  25                  30          


Gln Ala Arg Gly Ser Leu Ser Ala Thr Ala Ser His Thr Arg Ser Thr 
        35                  40                  45              


Ile 
    


<210>  7538
<211>  49
<212>  PRT
<213>  Homo Sapiens

<400>  7538

Met Trp Asp Leu Val Leu Ser Ile Ala Leu Ser Val Gly Cys Thr Gly 
1               5                   10                  15      


Ile Ala Arg Ser Gly Trp Val Gly Thr Thr Cys Leu Ser Leu Lys Thr 
            20                  25                  30          


Gln Ala Arg Gly Ser Leu Ser Ala Thr Ala Ser His Thr Arg Ser Thr 
        35                  40                  45              


Ile 
    


<210>  7539
<211>  51
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7539

Xaa Glu Lys Val Thr Glu Phe Met Leu Cys Ala Gly Leu Trp Thr Gly 
1               5                   10                  15      


Gly Lys Asp Thr Cys Gly His Asn Ser Pro Ile Pro Val Leu Ser Thr 
            20                  25                  30          


Cys Leu Leu Gly Thr Cys Tyr Val Thr Ser Ile Ala Val Asp Pro Gly 
        35                  40                  45              


Lys Gln Gln 
    50      


<210>  7540
<211>  184
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7540

Xaa Pro Asp Glu Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser 
1               5                   10                  15      


Glu Pro Ala Lys Ile Thr Asp Val Val Lys Val Leu Gly Leu Pro Thr 
            20                  25                  30          


Gln Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser 
        35                  40                  45              


Ile Glu Pro Glu Glu Phe Leu Arg Pro Arg Ser Leu Gln Cys Val Ser 
    50                  55                  60                  


Leu His Leu Leu Ser Asn Asp Met Cys Ala Arg Ala Tyr Ser Glu Lys 
65                  70                  75                  80  


Val Thr Glu Phe Met Leu Cys Ala Gly Leu Trp Thr Gly Gly Lys Asp 
                85                  90                  95      


Thr Cys Gly Glu Ser Gly Ala Val Asp Gly Ala Gly Gln Lys Lys Asp 
            100                 105                 110         


Arg Ala Trp Leu Arg Val Ile Leu Gly Val His Leu Ser Val Met Val 
        115                 120                 125             


Cys Phe Lys Val Ser His His Gly Ala Leu Ser His Val Pro Cys Leu 
    130                 135                 140                 


Lys Ser Leu Leu Cys Thr Pro Arg Trp Cys Ile Thr Gly Ser Gly Ser 
145                 150                 155                 160 


Arg Thr Pro Ser Gln Pro Thr Pro Glu Cys Pro Cys Pro Thr Pro Thr 
                165                 170                 175     


Ser Ser Lys Phe Lys Ser Thr Ser 
            180                 


<210>  7541
<211>  172
<212>  PRT
<213>  Homo Sapiens

<400>  7541

Met Trp Val Pro Val Val Phe Leu Thr Leu Ala Val Cys Gly Gly Val 
1               5                   10                  15      


Leu Val His Pro Gln Trp Val Leu Thr Ala Ala His Cys Ile Arg Asn 
            20                  25                  30          


Lys Ser Val Ile Leu Leu Gly Arg His Ser Leu Phe His Pro Glu Asp 
        35                  40                  45              


Thr Gly Gln Val Phe Gln Val Ser His Ser Phe Pro His Pro Leu Tyr 
    50                  55                  60                  


Asp Met Ser Leu Leu Lys Asn Arg Phe Leu Arg Pro Gly Asp Asp Ser 
65                  70                  75                  80  


Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu Pro Ala Glu Leu Thr 
                85                  90                  95      


Asp Ala Val Lys Val Met Asp Leu Pro Thr Gln Glu Pro Ala Leu Gly 
            100                 105                 110         


Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile Glu Pro Glu Glu Phe 
        115                 120                 125             


Leu Thr Pro Lys Lys Leu Gln Cys Val Asp Leu His Val Ile Ser Asn 
    130                 135                 140                 


Asp Val Cys Ala Gln Val His Pro Gln Lys Val Thr Lys Phe Met Leu 
145                 150                 155                 160 


Cys Ala Gly Arg Trp Thr Gly Gly Lys Ser Thr Cys 
                165                 170         


<210>  7542
<211>  173
<212>  PRT
<213>  Homo Sapiens

<400>  7542

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Ala 
1               5                   10                  15      


Pro Pro Leu Gln Val Leu Val Ala Ser Arg Gly Arg Ala Val Cys Gly 
            20                  25                  30          


Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala His Cys Ile 
        35                  40                  45              


Arg Asn Lys Ser Val Ile Leu Leu Gly Arg His Ser Leu Phe His Pro 
    50                  55                  60                  


Glu Asp Thr Gly Gln Val Phe Gln Val Ser His Ser Phe Pro His Pro 
65                  70                  75                  80  


Leu Tyr Asp Met Ser Leu Leu Lys Asn Arg Phe Leu Arg Pro Gly Asp 
                85                  90                  95      


Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu Pro Ala Glu 
            100                 105                 110         


Leu Thr Asp Ala Val Lys Val Met Asp Leu Pro Thr Gln Glu Pro Ala 
        115                 120                 125             


Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile Glu Pro Glu 
    130                 135                 140                 


Glu Phe Leu Thr Pro Lys Lys Leu Gln Cys Val Asp Leu His Val Ile 
145                 150                 155                 160 


Ser Asn Asp Val Cys Ala Gln Val His Pro Gln Lys Val 
                165                 170             


<210>  7543
<211>  218
<212>  PRT
<213>  Homo Sapiens

<400>  7543

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala 
        35                  40                  45              


Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Arg Lys Pro Gly Asp Asp Ser Ser His Asp Leu Met Leu 
65                  70                  75                  80  


Leu Arg Leu Ser Glu Pro Ala Glu Leu Thr Asp Ala Val Lys Val Met 
                85                  90                  95      


Asp Leu Pro Thr Gln Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser 
            100                 105                 110         


Gly Trp Gly Ser Ile Glu Pro Glu Glu Phe Leu Thr Pro Lys Lys Leu 
        115                 120                 125             


Gln Cys Val Asp Leu His Val Ile Ser Asn Asp Val Cys Ala Gln Val 
    130                 135                 140                 


His Pro Gln Lys Val Thr Lys Phe Met Leu Cys Ala Gly Arg Trp Thr 
145                 150                 155                 160 


Gly Gly Lys Ser Thr Cys Ser Gly Asp Ser Gly Gly Pro Leu Val Cys 
                165                 170                 175     


Asn Gly Val Leu Gln Gly Ile Thr Ser Trp Gly Ser Glu Pro Cys Ala 
            180                 185                 190         


Leu Pro Glu Arg Pro Ser Leu Tyr Thr Lys Val Val His Tyr Arg Lys 
        195                 200                 205             


Trp Ile Lys Asp Thr Ile Val Ala Asn Pro 
    210                 215             


<210>  7544
<211>  195
<212>  PRT
<213>  Homo Sapiens

<400>  7544

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala 
        35                  40                  45              


Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Arg Lys Pro Gly Asp Asp Ser Ser His Asp Leu Met Leu 
65                  70                  75                  80  


Leu Arg Leu Ser Glu Pro Ala Glu Leu Thr Asp Ala Val Lys Val Met 
                85                  90                  95      


Asp Leu Pro Thr Gln Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser 
            100                 105                 110         


Gly Trp Gly Ser Ile Glu Pro Glu Glu Phe Leu Thr Pro Lys Lys Leu 
        115                 120                 125             


Gln Cys Val Asp Leu His Val Ile Ser Asn Asp Val Cys Ala Gln Val 
    130                 135                 140                 


His Pro Gln Lys Val Thr Lys Phe Met Leu Cys Ala Gly Arg Trp Thr 
145                 150                 155                 160 


Gly Gly Lys Ser Thr Cys Ser Trp Val Ile Leu Ile Thr Glu Leu Thr 
                165                 170                 175     


Met Pro Ala Leu Pro Met Val Leu His Gly Ser Leu Val Pro Trp Arg 
            180                 185                 190         


Gly Gly Val 
        195 


<210>  7545
<211>  90
<212>  PRT
<213>  Homo Sapiens

<400>  7545

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala 
        35                  40                  45              


Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Arg Asn Lys Ser Val Ile Leu Leu Gly Arg His Ser Leu 
65                  70                  75                  80  


Phe His Pro Glu Asp Thr Gly Gln Ala Arg 
                85                  90  


<210>  7546
<211>  261
<212>  PRT
<213>  Homo Sapiens

<400>  7546

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala 
        35                  40                  45              


Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Arg Asn Lys Ser Val Ile Leu Leu Gly Arg His Ser Leu 
65                  70                  75                  80  


Phe His Pro Glu Asp Thr Gly Gln Val Phe Gln Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asp Met Ser Leu Leu Lys Asn Arg Phe Leu Arg 
            100                 105                 110         


Pro Gly Asp Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu 
        115                 120                 125             


Pro Ala Glu Leu Thr Asp Ala Val Lys Val Met Asp Leu Pro Thr Gln 
    130                 135                 140                 


Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Glu Phe Leu Thr Pro Lys Lys Leu Gln Cys Val Asp Leu 
                165                 170                 175     


His Val Ile Ser Asn Asp Val Cys Ala Gln Val His Pro Gln Lys Val 
            180                 185                 190         


Thr Lys Phe Met Leu Cys Ala Gly Arg Trp Thr Gly Gly Lys Ser Thr 
        195                 200                 205             


Cys Ser Gly Asp Ser Gly Gly Pro Leu Val Cys Asn Gly Val Leu Gln 
    210                 215                 220                 


Gly Ile Thr Ser Trp Gly Ser Glu Pro Cys Ala Leu Pro Glu Arg Pro 
225                 230                 235                 240 


Ser Leu Tyr Thr Lys Val Val His Tyr Arg Lys Trp Ile Lys Asp Thr 
                245                 250                 255     


Ile Val Ala Asn Pro 
            260     


<210>  7547
<211>  227
<212>  PRT
<213>  Homo Sapiens

<400>  7547

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala 
        35                  40                  45              


Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Arg Asn Lys Ser Val Ile Leu Leu Gly Arg His Ser Leu 
65                  70                  75                  80  


Phe His Pro Glu Asp Thr Gly Gln Val Phe Gln Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asp Met Ser Leu Leu Lys Asn Arg Phe Leu Arg 
            100                 105                 110         


Pro Gly Asp Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu 
        115                 120                 125             


Pro Ala Glu Leu Thr Asp Ala Val Lys Val Met Asp Leu Pro Thr Gln 
    130                 135                 140                 


Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Glu Phe Leu Thr Pro Lys Lys Leu Gln Cys Val Asp Leu 
                165                 170                 175     


His Val Ile Ser Asn Asp Val Cys Ala Gln Val His Pro Gln Lys Val 
            180                 185                 190         


Thr Lys Phe Met Leu Cys Ala Gly Arg Trp Thr Gly Gly Lys Ser Thr 
        195                 200                 205             


Cys Ser Val Ser His Pro Tyr Ser Gln Asp Leu Glu Gly Lys Gly Glu 
    210                 215                 220                 


Trp Gly Pro 
225         


<210>  7548
<211>  238
<212>  PRT
<213>  Homo Sapiens

<400>  7548

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala 
        35                  40                  45              


Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Arg Asn Lys Ser Val Ile Leu Leu Gly Arg His Ser Leu 
65                  70                  75                  80  


Phe His Pro Glu Asp Thr Gly Gln Val Phe Gln Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asp Met Ser Leu Leu Lys Asn Arg Phe Leu Arg 
            100                 105                 110         


Pro Gly Asp Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu 
        115                 120                 125             


Pro Ala Glu Leu Thr Asp Ala Val Lys Val Met Asp Leu Pro Thr Gln 
    130                 135                 140                 


Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Glu Phe Leu Thr Pro Lys Lys Leu Gln Cys Val Asp Leu 
                165                 170                 175     


His Val Ile Ser Asn Asp Val Cys Ala Gln Val His Pro Gln Lys Val 
            180                 185                 190         


Thr Lys Phe Met Leu Cys Ala Gly Arg Trp Thr Gly Gly Lys Ser Thr 
        195                 200                 205             


Cys Ser Trp Val Ile Leu Ile Thr Glu Leu Thr Met Pro Ala Leu Pro 
    210                 215                 220                 


Met Val Leu His Gly Ser Leu Val Pro Trp Arg Gly Gly Val 
225                 230                 235             


<210>  7549
<211>  220
<212>  PRT
<213>  Homo Sapiens

<400>  7549

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala 
        35                  40                  45              


Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Arg Asn Lys Ser Val Ile Leu Leu Gly Arg His Ser Leu 
65                  70                  75                  80  


Phe His Pro Glu Asp Thr Gly Gln Val Phe Gln Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asp Met Ser Leu Leu Lys Asn Arg Phe Leu Arg 
            100                 105                 110         


Pro Gly Asp Asp Ser Ser Ile Glu Pro Glu Glu Phe Leu Thr Pro Lys 
        115                 120                 125             


Lys Leu Gln Cys Val Asp Leu His Val Ile Ser Asn Asp Val Cys Ala 
    130                 135                 140                 


Gln Val His Pro Gln Lys Val Thr Lys Phe Met Leu Cys Ala Gly Arg 
145                 150                 155                 160 


Trp Thr Gly Gly Lys Ser Thr Cys Ser Gly Asp Ser Gly Gly Pro Leu 
                165                 170                 175     


Val Cys Asn Gly Val Leu Gln Gly Ile Thr Ser Trp Gly Ser Glu Pro 
            180                 185                 190         


Cys Ala Leu Pro Glu Arg Pro Ser Leu Tyr Thr Lys Val Val His Tyr 
        195                 200                 205             


Arg Lys Trp Ile Lys Asp Thr Ile Val Ala Asn Pro 
    210                 215                 220 


<210>  7550
<211>  124
<212>  PRT
<213>  Homo Sapiens

<400>  7550

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala 
        35                  40                  45              


Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Arg Asn Lys Ser Val Ile Leu Leu Gly Arg His Ser Leu 
65                  70                  75                  80  


Phe His Pro Glu Asp Thr Gly Gln Val Phe Gln Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asp Met Ser Leu Leu Lys Asn Arg Phe Leu Arg 
            100                 105                 110         


Pro Gly Asp Asp Ser Thr Leu Asn Gln Arg Ser Ser 
        115                 120                 


<210>  7551
<211>  104
<212>  PRT
<213>  Homo Sapiens

<400>  7551

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Glu Arg Gly His Gly Trp Gly Asp Ala Gly Glu Gly Ala Ser Pro Asp 
            20                  25                  30          


Cys Gln Ala Glu Ala Leu Ser Pro Pro Thr Gln His Pro Ser Pro Asp 
        35                  40                  45              


Arg Glu Leu Gly Ser Phe Leu Ser Leu Pro Ala Pro Leu Gln Ala His 
    50                  55                  60                  


Thr Pro Ser Pro Ser Ile Leu Gln Gln Ser Ser Leu Pro His Gln Val 
65                  70                  75                  80  


Pro Ala Pro Ser His Leu Pro Gln Asn Phe Leu Pro Ile Ala Gln Pro 
                85                  90                  95      


Ala Pro Cys Ser Gln Leu Leu Tyr 
            100                 


<210>  7552
<211>  262
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7552

Xaa Phe Leu Thr Leu Ser Val Thr Trp Ile Gly Ala Ala Pro Leu Ile 
1               5                   10                  15      


Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu Lys His Ser Gln Pro 
            20                  25                  30          


Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala Val Cys Gly Gly Val 
        35                  40                  45              


Leu Val His Pro Gln Trp Val Leu Thr Ala Ala His Cys Ile Arg Asn 
    50                  55                  60                  


Lys Ser Val Ile Leu Leu Gly Arg His Ser Leu Phe His Pro Glu Asp 
65                  70                  75                  80  


Thr Gly Gln Val Phe Gln Val Ser His Ser Phe Pro His Pro Leu Tyr 
                85                  90                  95      


Asp Met Ser Leu Leu Lys Asn Arg Phe Leu Arg Pro Gly Asp Asp Ser 
            100                 105                 110         


Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu Pro Ala Glu Leu Thr 
        115                 120                 125             


Asp Ala Val Lys Val Met Asp Leu Pro Thr Gln Glu Pro Ala Leu Gly 
    130                 135                 140                 


Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile Glu Pro Glu Glu Cys 
145                 150                 155                 160 


Thr Pro Gly Pro Asp Val Leu Thr Pro Lys Lys Leu Gln Cys Val Asp 
                165                 170                 175     


Leu His Val Ile Ser Asn Asp Val Cys Ala Gln Val His Pro Gln Lys 
            180                 185                 190         


Val Thr Lys Phe Met Leu Cys Ala Gly Arg Trp Thr Gly Gly Lys Ser 
        195                 200                 205             


Thr Cys Ser Gly Asp Ser Gly Gly Pro Leu Val Cys Asn Gly Val Leu 
    210                 215                 220                 


Gln Gly Ile Thr Ser Trp Gly Ser Glu Pro Cys Ala Leu Pro Glu Arg 
225                 230                 235                 240 


Pro Ser Leu Tyr Thr Lys Val Val His Tyr Arg Lys Trp Ile Lys Asp 
                245                 250                 255     


Thr Ile Val Ala Asn Pro 
            260         


<210>  7553
<211>  75
<212>  PRT
<213>  Homo Sapiens

<400>  7553

Met Ala Thr Ala Gly Asn Pro Trp Gly Trp Phe Leu Gly Tyr Leu Ile 
1               5                   10                  15      


Leu Gly Val Ala Gly Ser Leu Val Ser Gly Ser Cys Ser Gln Ile Ile 
            20                  25                  30          


Asn Gly Glu Asp Cys Ser Pro His Ser Gln Pro Trp Gln Ala Ala Leu 
        35                  40                  45              


Val Met Glu Asn Glu Leu Phe Cys Ser Gly Val Leu Val His Pro Gln 
    50                  55                  60                  


Trp Val Leu Ser Ala Ala His Cys Phe Gln Lys 
65                  70                  75  


<210>  7554
<211>  254
<212>  PRT
<213>  Homo Sapiens

<400>  7554

Met Ala Thr Ala Gly Asn Pro Trp Gly Trp Phe Leu Gly Tyr Leu Ile 
1               5                   10                  15      


Leu Gly Val Ala Gly Ser Leu Val Ser Gly Ser Cys Ser Gln Ile Ile 
            20                  25                  30          


Asn Gly Glu Asp Cys Ser Pro His Ser Gln Pro Trp Gln Ala Ala Leu 
        35                  40                  45              


Val Met Glu Asn Glu Leu Phe Cys Ser Gly Val Leu Val His Pro Gln 
    50                  55                  60                  


Trp Val Leu Ser Ala Ala His Cys Phe Gln Asn Ser Tyr Thr Ile Gly 
65                  70                  75                  80  


Leu Gly Leu His Ser Leu Glu Ala Asp Gln Glu Pro Gly Ser Gln Met 
                85                  90                  95      


Val Glu Ala Ser Leu Ser Val Arg His Pro Glu Tyr Asn Arg Pro Leu 
            100                 105                 110         


Leu Ala Asn Asp Leu Met Leu Ile Lys Leu Asp Glu Ser Val Ser Glu 
        115                 120                 125             


Ser Asp Thr Ile Arg Ser Ile Ser Ile Ala Ser Gln Cys Pro Thr Ala 
    130                 135                 140                 


Gly Asn Ser Cys Leu Val Ser Gly Trp Gly Leu Leu Ala Asn Gly Arg 
145                 150                 155                 160 


Met Pro Thr Val Leu Gln Cys Val Asn Val Ser Val Val Ser Glu Glu 
                165                 170                 175     


Val Cys Ser Lys Leu Tyr Asp Pro Leu Tyr His Pro Ser Met Phe Cys 
            180                 185                 190         


Ala Gly Gly Gly Gln Asp Gln Lys Asp Ser Cys Asn Gly Asp Ser Gly 
        195                 200                 205             


Gly Pro Leu Ile Cys Asn Gly Tyr Leu Gln Gly Leu Val Ser Phe Gly 
    210                 215                 220                 


Lys Ala Pro Cys Gly Gln Val Gly Val Pro Gly Val Tyr Thr Asn Leu 
225                 230                 235                 240 


Cys Lys Phe Thr Glu Trp Ile Glu Lys Thr Val Gln Ala Ser 
                245                 250                 


<210>  7555
<211>  110
<212>  PRT
<213>  Homo Sapiens

<400>  7555

Met Glu Asn Glu Leu Phe Cys Ser Gly Val Leu Val His Pro Gln Trp 
1               5                   10                  15      


Val Leu Ser Ala Ala His Cys Phe Gln Asn Ser Tyr Thr Ile Gly Leu 
            20                  25                  30          


Gly Leu His Ser Leu Glu Ala Asp Gln Glu Pro Gly Ser Gln Met Val 
        35                  40                  45              


Glu Ala Ser Leu Ser Val Arg His Pro Glu Tyr Asn Arg Pro Leu Leu 
    50                  55                  60                  


Ala Asn Asp Leu Met Leu Ile Lys Leu Asp Glu Ser Val Ser Glu Ser 
65                  70                  75                  80  


Asp Thr Ile Arg Ser Ile Ser Ile Ala Ser Gln Cys Pro Thr Ala Gly 
                85                  90                  95      


Asn Ser Cys Leu Val Ser Gly Trp Gly Leu Leu Ala Asn Gly 
            100                 105                 110 


<210>  7556
<211>  71
<212>  PRT
<213>  Homo Sapiens

<400>  7556

Met Val Glu Ala Ser Leu Ser Val Arg His Pro Glu Tyr Asn Arg Pro 
1               5                   10                  15      


Leu Leu Ala Asn Asp Leu Met Leu Ile Lys Leu Asp Glu Ser Val Ser 
            20                  25                  30          


Glu Ser Asp Thr Ile Arg Ser Ile Ser Ile Ala Ser Gln Cys Pro Thr 
        35                  40                  45              


Ala Gly Asn Ser Cys Leu Val Ser Gly Trp Gly Leu Leu Ala Asn Glu 
    50                  55                  60                  


Cys Leu Pro Cys Cys Ser Ala 
65                  70      


<210>  7557
<211>  71
<212>  PRT
<213>  Homo Sapiens

<400>  7557

Met Val Glu Ala Ser Leu Ser Val Arg His Pro Glu Tyr Asn Arg Pro 
1               5                   10                  15      


Leu Leu Ala Asn Asp Leu Met Leu Ile Lys Leu Asp Glu Ser Val Ser 
            20                  25                  30          


Glu Ser Asp Thr Ile Arg Ser Ile Ser Ile Ala Ser Gln Cys Pro Thr 
        35                  40                  45              


Ala Gly Asn Ser Cys Leu Val Ser Gly Trp Gly Leu Leu Ala Asn Glu 
    50                  55                  60                  


Cys Leu Pro Cys Cys Ser Ala 
65                  70      


<210>  7558
<211>  205
<212>  PRT
<213>  Homo Sapiens

<400>  7558

Met Ala Thr Ala Arg Pro Pro Trp Met Trp Val Leu Cys Ala Leu Ile 
1               5                   10                  15      


Thr Ala Leu Leu Leu Gly Val Thr Glu His Val Leu Ala Asn Asn Asp 
            20                  25                  30          


Val Ser Cys Asp His Pro Ser Asn Thr Val Pro Ser Gly Ser Asn Gln 
        35                  40                  45              


Asp Leu Gly Ala Gly Ala Gly Glu Asp Ala Arg Ser Asp Asp Ser Ser 
    50                  55                  60                  


Ser Arg Ile Ile Asn Gly Ser Asp Cys Asp Met His Thr Gln Pro Trp 
65                  70                  75                  80  


Gln Ala Ala Leu Leu Leu Arg Pro Asn Gln Leu Tyr Cys Gly Ala Val 
                85                  90                  95      


Leu Val His Pro Gln Trp Leu Leu Thr Ala Ala His Cys Arg Lys Lys 
            100                 105                 110         


Val Phe Arg Val Arg Leu Gly His Tyr Ser Leu Ser Pro Val Tyr Glu 
        115                 120                 125             


Ser Gly Gln Gln Met Phe Gln Gly Val Lys Ser Ile Pro His Pro Gly 
    130                 135                 140                 


Tyr Ser His Pro Gly His Ser Asn Asp Leu Met Leu Ile Lys Leu Asn 
145                 150                 155                 160 


Arg Arg Ile Arg Pro Thr Lys Asp Val Arg Pro Ile Asn Val Ser Ser 
                165                 170                 175     


His Cys Pro Ser Ala Gly Thr Lys Cys Leu Val Ser Gly Trp Gly Thr 
            180                 185                 190         


Thr Lys Ser Pro Gln Val His Phe Pro Lys Val Leu Gln 
        195                 200                 205 


<210>  7559
<211>  293
<212>  PRT
<213>  Homo Sapiens

<400>  7559

Met Ala Thr Ala Arg Pro Pro Trp Met Trp Val Leu Cys Ala Leu Ile 
1               5                   10                  15      


Thr Ala Leu Leu Leu Gly Val Thr Glu His Val Leu Ala Asn Asn Asp 
            20                  25                  30          


Val Ser Cys Asp His Pro Ser Asn Thr Val Pro Ser Gly Ser Asn Gln 
        35                  40                  45              


Asp Leu Gly Ala Gly Ala Gly Glu Asp Ala Arg Ser Asp Asp Ser Ser 
    50                  55                  60                  


Ser Arg Ile Ile Asn Gly Ser Asp Cys Asp Met His Thr Gln Pro Trp 
65                  70                  75                  80  


Gln Ala Ala Leu Leu Leu Arg Pro Asn Gln Leu Tyr Cys Gly Ala Val 
                85                  90                  95      


Leu Val His Pro Gln Trp Leu Leu Thr Ala Ala His Cys Arg Lys Lys 
            100                 105                 110         


Val Phe Arg Val Arg Leu Gly His Tyr Ser Leu Ser Pro Val Tyr Glu 
        115                 120                 125             


Ser Gly Gln Gln Met Phe Gln Gly Val Lys Ser Ile Pro His Pro Gly 
    130                 135                 140                 


Tyr Ser His Pro Gly His Ser Asn Asp Leu Met Leu Ile Lys Leu Asn 
145                 150                 155                 160 


Arg Arg Ile Arg Pro Thr Lys Asp Val Arg Pro Ile Asn Val Ser Ser 
                165                 170                 175     


His Cys Pro Ser Ala Gly Thr Lys Cys Leu Val Ser Gly Trp Gly Thr 
            180                 185                 190         


Thr Lys Ser Pro Gln Val His Phe Pro Lys Val Leu Gln Cys Leu Asn 
        195                 200                 205             


Ile Ser Val Leu Ser Gln Lys Arg Cys Glu Asp Ala Tyr Pro Arg Gln 
    210                 215                 220                 


Ile Asp Asp Thr Met Phe Cys Ala Gly Asp Lys Ala Gly Arg Asp Ser 
225                 230                 235                 240 


Cys Gln Gly Asp Ser Gly Gly Pro Val Val Cys Asn Gly Ser Leu Gln 
                245                 250                 255     


Gly Leu Val Ser Trp Gly Asp Tyr Pro Cys Ala Arg Pro Asn Arg Pro 
            260                 265                 270         


Gly Val Tyr Thr Asn Leu Cys Lys Phe Thr Lys Trp Ile Gln Glu Thr 
        275                 280                 285             


Ile Gln Ala Asn Ser 
    290             


<210>  7560
<211>  293
<212>  PRT
<213>  Homo Sapiens

<400>  7560

Met Ala Thr Ala Arg Pro Pro Trp Met Trp Val Leu Cys Ala Leu Ile 
1               5                   10                  15      


Thr Ala Leu Leu Leu Gly Val Thr Glu His Val Leu Ala Asn Asn Asp 
            20                  25                  30          


Val Ser Cys Asp His Pro Ser Asn Thr Val Pro Ser Gly Ser Asn Gln 
        35                  40                  45              


Asp Leu Gly Ala Gly Ala Gly Glu Asp Ala Arg Ser Asp Asp Ser Ser 
    50                  55                  60                  


Ser Arg Ile Ile Asn Gly Ser Asp Cys Asp Met His Thr Gln Pro Trp 
65                  70                  75                  80  


Gln Ala Ala Leu Leu Leu Arg Pro Asn Gln Leu Tyr Cys Gly Ala Val 
                85                  90                  95      


Leu Val His Pro Gln Trp Leu Leu Thr Ala Ala His Cys Arg Lys Lys 
            100                 105                 110         


Val Phe Arg Val Arg Leu Gly His Tyr Ser Leu Ser Pro Val Tyr Glu 
        115                 120                 125             


Ser Gly Gln Gln Met Phe Gln Gly Val Lys Ser Ile Pro His Pro Gly 
    130                 135                 140                 


Tyr Ser His Pro Gly His Ser Asn Asp Leu Met Leu Ile Lys Leu Asn 
145                 150                 155                 160 


Arg Arg Ile Arg Pro Thr Lys Asp Val Arg Pro Ile Asn Val Ser Ser 
                165                 170                 175     


His Cys Pro Ser Ala Gly Thr Lys Cys Leu Val Ser Gly Trp Gly Thr 
            180                 185                 190         


Thr Lys Ser Pro Gln Val His Phe Pro Lys Val Leu Gln Cys Leu Asn 
        195                 200                 205             


Ile Ser Val Leu Ser Gln Lys Arg Cys Glu Asp Ala Tyr Pro Arg Gln 
    210                 215                 220                 


Ile Asp Asp Thr Met Phe Cys Ala Gly Asp Lys Ala Gly Arg Asp Ser 
225                 230                 235                 240 


Cys Gln Gly Asp Ser Gly Gly Pro Val Val Cys Asn Gly Ser Leu Gln 
                245                 250                 255     


Gly Leu Val Ser Trp Gly Asp Tyr Pro Cys Ala Arg Pro Asn Arg Pro 
            260                 265                 270         


Gly Val Tyr Thr Asn Leu Cys Lys Phe Thr Lys Trp Ile Gln Glu Thr 
        275                 280                 285             


Ile Gln Ala Asn Ser 
    290             


<210>  7561
<211>  293
<212>  PRT
<213>  Homo Sapiens

<400>  7561

Met Ala Thr Ala Arg Pro Pro Trp Met Trp Val Leu Cys Ala Leu Ile 
1               5                   10                  15      


Thr Ala Leu Leu Leu Gly Val Thr Glu His Val Leu Ala Asn Asn Asp 
            20                  25                  30          


Val Ser Cys Asp His Pro Ser Asn Thr Val Pro Ser Gly Ser Asn Gln 
        35                  40                  45              


Asp Leu Gly Ala Gly Ala Gly Glu Asp Ala Arg Ser Asp Asp Ser Ser 
    50                  55                  60                  


Ser Arg Ile Ile Asn Gly Ser Asp Cys Asp Met His Thr Gln Pro Trp 
65                  70                  75                  80  


Gln Ala Ala Leu Leu Leu Arg Pro Asn Gln Leu Tyr Cys Gly Ala Val 
                85                  90                  95      


Leu Val His Pro Gln Trp Leu Leu Thr Ala Ala His Cys Arg Lys Lys 
            100                 105                 110         


Val Phe Arg Val Arg Leu Gly His Tyr Ser Leu Ser Pro Val Tyr Glu 
        115                 120                 125             


Ser Gly Gln Gln Met Phe Gln Gly Val Lys Ser Ile Pro His Pro Gly 
    130                 135                 140                 


Tyr Ser His Pro Gly His Ser Asn Asp Leu Met Leu Ile Lys Leu Asn 
145                 150                 155                 160 


Arg Arg Ile Arg Pro Thr Lys Asp Val Arg Pro Ile Asn Val Ser Ser 
                165                 170                 175     


His Cys Pro Ser Ala Gly Thr Lys Cys Leu Val Ser Gly Trp Gly Thr 
            180                 185                 190         


Thr Lys Ser Pro Gln Val His Phe Pro Lys Val Leu Gln Cys Leu Asn 
        195                 200                 205             


Ile Ser Val Leu Ser Gln Lys Arg Cys Glu Asp Ala Tyr Pro Arg Gln 
    210                 215                 220                 


Ile Asp Asp Thr Met Phe Cys Ala Gly Asp Lys Ala Gly Arg Asp Ser 
225                 230                 235                 240 


Cys Gln Gly Asp Ser Gly Gly Pro Val Val Cys Asn Gly Ser Leu Gln 
                245                 250                 255     


Gly Leu Val Ser Trp Gly Asp Tyr Pro Cys Ala Arg Pro Asn Arg Pro 
            260                 265                 270         


Gly Val Tyr Thr Asn Leu Cys Lys Phe Thr Lys Trp Ile Gln Glu Thr 
        275                 280                 285             


Ile Gln Ala Asn Ser 
    290             


<210>  7562
<211>  69
<212>  PRT
<213>  Homo Sapiens

<400>  7562

Met Ala Asp Pro Ala Thr Arg His Leu Thr Pro Thr Lys Leu Pro Ser 
1               5                   10                  15      


Thr Pro Arg Ala Thr Cys Ser Val Val Gly Ser Leu Ser Ile His Cys 
            20                  25                  30          


Gly Ser Ser Gln Leu Pro Thr Ala Lys Asn Arg Ile Phe Arg Ser Ser 
        35                  40                  45              


Trp Gly Ser Ile Thr Phe Gly Lys Gly Arg Val Pro Arg Ser Arg Val 
    50                  55                  60                  


Leu Leu Ser Gly Leu 
65                  


<210>  7563
<211>  244
<212>  PRT
<213>  Homo Sapiens

<400>  7563

Met Lys Lys Leu Met Val Val Leu Ser Leu Ile Ala Ala Ala Trp Ala 
1               5                   10                  15      


Glu Glu Gln Asn Lys Leu Val His Gly Gly Pro Cys Asp Lys Thr Ser 
            20                  25                  30          


His Pro Tyr Gln Ala Ala Leu Tyr Thr Ser Gly His Leu Leu Cys Gly 
        35                  40                  45              


Gly Val Leu Ile His Pro Leu Trp Val Leu Thr Ala Ala His Cys Lys 
    50                  55                  60                  


Lys Pro Asn Leu Gln Val Phe Leu Gly Lys His Asn Leu Arg Gln Arg 
65                  70                  75                  80  


Glu Ser Ser Gln Glu Gln Ser Ser Val Val Arg Ala Val Ile His Pro 
                85                  90                  95      


Asp Tyr Asp Ala Ala Ser His Asp Gln Asp Ile Met Leu Leu Arg Leu 
            100                 105                 110         


Ala Arg Pro Ala Lys Leu Ser Glu Leu Ile Gln Pro Leu Pro Leu Glu 
        115                 120                 125             


Arg Asp Cys Ser Ala Asn Thr Thr Ser Cys His Ile Leu Gly Trp Gly 
    130                 135                 140                 


Lys Thr Ala Asp Gly Asp Phe Pro Asp Thr Ile Gln Cys Ala Tyr Ile 
145                 150                 155                 160 


His Leu Val Ser Arg Glu Glu Cys Glu His Ala Tyr Pro Gly Gln Ile 
                165                 170                 175     


Thr Gln Asn Met Leu Cys Ala Gly Asp Glu Lys Tyr Gly Lys Asp Ser 
            180                 185                 190         


Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Gly Asp His Leu Arg 
        195                 200                 205             


Gly Leu Val Ser Trp Gly Asn Ile Pro Cys Gly Ser Lys Glu Lys Pro 
    210                 215                 220                 


Gly Val Tyr Thr Asn Val Cys Arg Tyr Thr Asn Trp Ile Gln Lys Thr 
225                 230                 235                 240 


Ile Gln Ala Lys 
                


<210>  7564
<211>  244
<212>  PRT
<213>  Homo Sapiens

<400>  7564

Met Lys Lys Leu Met Val Val Leu Ser Leu Ile Ala Ala Ala Trp Ala 
1               5                   10                  15      


Glu Glu Gln Asn Lys Leu Val His Gly Gly Pro Cys Asp Lys Thr Ser 
            20                  25                  30          


His Pro Tyr Gln Ala Ala Leu Tyr Thr Ser Gly His Leu Leu Cys Gly 
        35                  40                  45              


Gly Val Leu Ile His Pro Leu Trp Val Leu Thr Ala Ala His Cys Lys 
    50                  55                  60                  


Lys Pro Asn Leu Gln Val Phe Leu Gly Lys His Asn Leu Arg Gln Arg 
65                  70                  75                  80  


Glu Ser Ser Gln Glu Gln Ser Ser Val Val Arg Ala Val Ile His Pro 
                85                  90                  95      


Asp Tyr Asp Ala Ala Ser His Asp Gln Asp Ile Met Leu Leu Arg Leu 
            100                 105                 110         


Ala Arg Pro Ala Lys Leu Ser Glu Leu Ile Gln Pro Leu Pro Leu Glu 
        115                 120                 125             


Arg Asp Cys Ser Ala Asn Thr Thr Ser Cys His Ile Leu Gly Trp Gly 
    130                 135                 140                 


Lys Thr Ala Asp Gly Asp Phe Pro Asp Thr Ile Gln Cys Ala Tyr Ile 
145                 150                 155                 160 


His Leu Val Ser Arg Glu Glu Cys Glu His Ala Tyr Pro Gly Gln Ile 
                165                 170                 175     


Thr Gln Asn Met Leu Cys Ala Gly Asp Glu Lys Tyr Gly Lys Asp Ser 
            180                 185                 190         


Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Gly Asp His Leu Arg 
        195                 200                 205             


Gly Leu Val Ser Trp Gly Asn Ile Pro Cys Gly Ser Lys Glu Lys Pro 
    210                 215                 220                 


Gly Val Tyr Thr Asn Val Cys Arg Tyr Thr Asn Trp Ile Gln Lys Thr 
225                 230                 235                 240 


Ile Gln Ala Lys 
                


<210>  7565
<211>  244
<212>  PRT
<213>  Homo Sapiens

<400>  7565

Met Lys Lys Leu Met Val Val Leu Ser Leu Ile Ala Ala Ala Trp Ala 
1               5                   10                  15      


Glu Glu Gln Asn Lys Leu Val His Gly Gly Pro Cys Asp Lys Thr Ser 
            20                  25                  30          


His Pro Tyr Gln Ala Ala Leu Tyr Thr Ser Gly His Leu Leu Cys Gly 
        35                  40                  45              


Gly Val Leu Ile His Pro Leu Trp Val Leu Thr Ala Ala His Cys Lys 
    50                  55                  60                  


Lys Pro Asn Leu Gln Val Phe Leu Gly Lys His Asn Leu Arg Gln Arg 
65                  70                  75                  80  


Glu Ser Ser Gln Glu Gln Ser Ser Val Val Arg Ala Val Ile His Pro 
                85                  90                  95      


Asp Tyr Asp Ala Ala Ser His Asp Gln Asp Ile Met Leu Leu Arg Leu 
            100                 105                 110         


Ala Arg Pro Ala Lys Leu Ser Glu Leu Ile Gln Pro Leu Pro Leu Glu 
        115                 120                 125             


Arg Asp Cys Ser Ala Asn Thr Thr Ser Cys His Ile Leu Gly Trp Gly 
    130                 135                 140                 


Lys Thr Ala Asp Gly Asp Phe Pro Asp Thr Ile Gln Cys Ala Tyr Ile 
145                 150                 155                 160 


His Leu Val Ser Arg Glu Glu Cys Glu His Ala Tyr Pro Gly Gln Ile 
                165                 170                 175     


Thr Gln Asn Met Leu Cys Ala Gly Asp Glu Lys Tyr Gly Lys Asp Ser 
            180                 185                 190         


Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Gly Asp His Leu Arg 
        195                 200                 205             


Gly Leu Val Ser Trp Gly Asn Ile Pro Cys Gly Ser Lys Glu Lys Pro 
    210                 215                 220                 


Gly Val Tyr Thr Asn Val Cys Arg Tyr Thr Asn Trp Ile Gln Lys Thr 
225                 230                 235                 240 


Ile Gln Ala Lys 
                


<210>  7566
<211>  40
<212>  PRT
<213>  Homo Sapiens

<400>  7566

Met Lys Lys Leu Met Val Val Leu Ser Leu Ile Ala Ala Gly Ile Phe 
1               5                   10                  15      


Arg Ser Ser Trp Gly Ser Ile Thr Phe Gly Lys Gly Arg Val Pro Arg 
            20                  25                  30          


Ser Arg Val Leu Leu Ser Gly Leu 
        35                  40  


<210>  7567
<211>  40
<212>  PRT
<213>  Homo Sapiens

<400>  7567

Met Lys Lys Leu Met Val Val Leu Ser Leu Ile Ala Ala Gly Ile Phe 
1               5                   10                  15      


Arg Ser Ser Trp Gly Ser Ile Thr Phe Gly Lys Gly Arg Val Pro Arg 
            20                  25                  30          


Ser Arg Val Leu Leu Ser Gly Leu 
        35                  40  


<210>  7568
<211>  137
<212>  PRT
<213>  Homo Sapiens

<400>  7568

Met Leu Leu Arg Leu Ala Arg Pro Ala Lys Leu Ser Glu Leu Ile Gln 
1               5                   10                  15      


Pro Leu Pro Leu Glu Arg Asp Cys Ser Ala Asn Thr Thr Ser Cys His 
            20                  25                  30          


Ile Leu Gly Trp Gly Lys Thr Ala Asp Gly Asp Phe Pro Asp Thr Ile 
        35                  40                  45              


Gln Cys Ala Tyr Ile His Leu Val Ser Arg Glu Glu Cys Glu His Ala 
    50                  55                  60                  


Tyr Pro Gly Gln Ile Thr Gln Asn Met Leu Cys Ala Gly Asp Glu Lys 
65                  70                  75                  80  


Tyr Gly Lys Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys 
                85                  90                  95      


Gly Asp His Leu Arg Gly Leu Val Ser Trp Gly Asn Ile Pro Cys Gly 
            100                 105                 110         


Ser Lys Glu Lys Pro Gly Val Tyr Thr Asn Val Cys Arg Tyr Thr Asn 
        115                 120                 125             


Trp Ile Gln Lys Thr Ile Gln Ala Lys 
    130                 135         


<210>  7569
<211>  253
<212>  PRT
<213>  Homo Sapiens

<400>  7569

Met Ala Arg Ser Leu Leu Leu Pro Leu Gln Ile Leu Leu Leu Ser Leu 
1               5                   10                  15      


Ala Leu Glu Thr Ala Gly Glu Glu Ala Gln Gly Asp Lys Ile Ile Asp 
            20                  25                  30          


Gly Ala Pro Cys Ala Arg Gly Ser His Pro Trp Gln Val Ala Leu Leu 
        35                  40                  45              


Ser Gly Asn Gln Leu His Cys Gly Gly Val Leu Val Asn Glu Arg Trp 
    50                  55                  60                  


Val Leu Thr Ala Ala His Cys Lys Met Asn Glu Tyr Thr Val His Leu 
65                  70                  75                  80  


Gly Ser Asp Thr Leu Gly Asp Arg Arg Ala Gln Arg Ile Lys Ala Ser 
                85                  90                  95      


Lys Ser Phe Arg His Pro Gly Tyr Ser Thr Gln Thr His Val Asn Asp 
            100                 105                 110         


Leu Met Leu Val Lys Leu Asn Ser Gln Ala Arg Leu Ser Ser Met Val 
        115                 120                 125             


Lys Lys Val Arg Leu Pro Ser Arg Cys Glu Pro Pro Gly Thr Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Trp Gly Thr Thr Thr Ser Pro Asp Val Thr Phe Pro 
145                 150                 155                 160 


Ser Asp Leu Met Cys Val Asp Val Lys Leu Ile Ser Pro Gln Asp Cys 
                165                 170                 175     


Thr Lys Val Tyr Lys Asp Leu Leu Glu Asn Ser Met Leu Cys Ala Gly 
            180                 185                 190         


Ile Pro Asp Ser Lys Lys Asn Ala Cys Asn Gly Asp Ser Gly Gly Pro 
        195                 200                 205             


Leu Val Cys Arg Gly Thr Leu Gln Gly Leu Val Ser Trp Gly Thr Phe 
    210                 215                 220                 


Pro Cys Gly Gln Pro Asn Asp Pro Gly Val Tyr Thr Gln Val Cys Lys 
225                 230                 235                 240 


Phe Thr Lys Trp Ile Asn Asp Thr Met Lys Lys His Arg 
                245                 250             


<210>  7570
<211>  253
<212>  PRT
<213>  Homo Sapiens

<400>  7570

Met Ala Arg Ser Leu Leu Leu Pro Leu Gln Ile Leu Leu Leu Ser Leu 
1               5                   10                  15      


Ala Leu Glu Thr Ala Gly Glu Glu Ala Gln Gly Asp Lys Ile Ile Asp 
            20                  25                  30          


Gly Ala Pro Cys Ala Arg Gly Ser His Pro Trp Gln Val Ala Leu Leu 
        35                  40                  45              


Ser Gly Asn Gln Leu His Cys Gly Gly Val Leu Val Asn Glu Arg Trp 
    50                  55                  60                  


Val Leu Thr Ala Ala His Cys Lys Met Asn Glu Tyr Thr Val His Leu 
65                  70                  75                  80  


Gly Ser Asp Thr Leu Gly Asp Arg Arg Ala Gln Arg Ile Lys Ala Ser 
                85                  90                  95      


Lys Ser Phe Arg His Pro Gly Tyr Ser Thr Gln Thr His Val Asn Asp 
            100                 105                 110         


Leu Met Leu Val Lys Leu Asn Ser Gln Ala Arg Leu Ser Ser Met Val 
        115                 120                 125             


Lys Lys Val Arg Leu Pro Ser Arg Cys Glu Pro Pro Gly Thr Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Trp Gly Thr Thr Thr Ser Pro Asp Val Thr Phe Pro 
145                 150                 155                 160 


Ser Asp Leu Met Cys Val Asp Val Lys Leu Ile Ser Pro Gln Asp Cys 
                165                 170                 175     


Thr Lys Val Tyr Lys Asp Leu Leu Glu Asn Ser Met Leu Cys Ala Gly 
            180                 185                 190         


Ile Pro Asp Ser Lys Lys Asn Ala Cys Asn Gly Asp Ser Gly Gly Pro 
        195                 200                 205             


Leu Val Cys Arg Gly Thr Leu Gln Gly Leu Val Ser Trp Gly Thr Phe 
    210                 215                 220                 


Pro Cys Gly Gln Pro Asn Asp Pro Gly Val Tyr Thr Gln Val Cys Lys 
225                 230                 235                 240 


Phe Thr Lys Trp Ile Asn Asp Thr Met Lys Lys His Arg 
                245                 250             


<210>  7571
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  7571

Met Ala Arg Ser Leu Leu Leu Pro Leu Gln Ile Leu Leu Leu Ser Leu 
1               5                   10                  15      


Ala Leu Glu Thr Ala Gly Glu Glu Val Ser Thr Pro Cys Thr Trp Ala 
            20                  25                  30          


Val Ile Arg Trp Ala Thr Gly Glu Leu Arg Gly Ser Arg Pro Arg Ser 
        35                  40                  45              


His Ser Ala Thr Pro Ala Thr Pro His Arg Pro Met Leu Met Thr Ser 
    50                  55                  60                  


Cys Ser 
65      


<210>  7572
<211>  69
<212>  PRT
<213>  Homo Sapiens

<400>  7572

Met Asn Glu Tyr Thr Val His Leu Gly Ser Asp Thr Leu Gly Asp Arg 
1               5                   10                  15      


Arg Ala Gln Arg Ile Lys Ala Ser Lys Ser Phe Arg His Pro Gly Tyr 
            20                  25                  30          


Ser Thr Gln Thr His Val Asn Asp Leu Met Leu Val Lys Leu Asn Ser 
        35                  40                  45              


Gln Ala Arg Leu Ser Ser Met Val Lys Lys Val Arg Leu Pro Ser Arg 
    50                  55                  60                  


Cys Glu Pro Pro Gly 
65                  


<210>  7573
<211>  181
<212>  PRT
<213>  Homo Sapiens

<400>  7573

Met Asn Glu Tyr Thr Val His Leu Gly Ser Asp Thr Leu Gly Asp Arg 
1               5                   10                  15      


Arg Ala Gln Arg Ile Lys Ala Ser Lys Ser Phe Arg His Pro Gly Tyr 
            20                  25                  30          


Ser Thr Gln Thr His Val Asn Asp Leu Met Leu Val Lys Leu Asn Ser 
        35                  40                  45              


Gln Ala Arg Leu Ser Ser Met Val Lys Lys Val Arg Leu Pro Ser Arg 
    50                  55                  60                  


Cys Glu Pro Pro Gly Thr Thr Cys Thr Val Ser Gly Trp Gly Thr Thr 
65                  70                  75                  80  


Thr Ser Pro Asp Val Thr Phe Pro Ser Asp Leu Met Cys Val Asp Val 
                85                  90                  95      


Lys Leu Ile Ser Pro Gln Asp Cys Thr Lys Val Tyr Lys Asp Leu Leu 
            100                 105                 110         


Glu Asn Ser Met Leu Cys Ala Gly Ile Pro Asp Ser Lys Lys Asn Ala 
        115                 120                 125             


Cys Asn Gly Asp Ser Gly Gly Pro Leu Val Cys Arg Gly Thr Leu Gln 
    130                 135                 140                 


Gly Leu Val Ser Trp Gly Thr Phe Pro Cys Gly Gln Pro Asn Asp Pro 
145                 150                 155                 160 


Gly Val Tyr Thr Gln Val Cys Lys Phe Thr Lys Trp Ile Asn Asp Thr 
                165                 170                 175     


Met Lys Lys His Arg 
            180     


<210>  7574
<211>  305
<212>  PRT
<213>  Homo Sapiens

<400>  7574

Met Gly Arg Pro Arg Pro Arg Ala Ala Lys Thr Trp Met Phe Leu Leu 
1               5                   10                  15      


Leu Leu Gly Gly Ala Trp Ala Ala Cys Gly Ser Leu Asp Leu Leu Thr 
            20                  25                  30          


Lys Leu Tyr Ala Glu Asn Leu Pro Cys Val His Leu Asn Pro Gln Trp 
        35                  40                  45              


Pro Ser Gln Pro Ser His Cys Pro Arg Gly Trp Arg Ser Asn Pro Leu 
    50                  55                  60                  


Pro Pro Ala Ala Gly His Ser Arg Ala Gln Glu Asp Lys Val Leu Gly 
65                  70                  75                  80  


Gly His Glu Cys Gln Pro His Ser Gln Pro Trp Gln Ala Ala Leu Phe 
                85                  90                  95      


Gln Gly Gln Gln Leu Leu Cys Gly Gly Val Leu Val Gly Gly Asn Trp 
            100                 105                 110         


Val Leu Thr Ala Ala His Cys Lys Lys Pro Lys Tyr Thr Val Arg Leu 
        115                 120                 125             


Gly Asp His Ser Leu Gln Asn Lys Asp Gly Pro Glu Gln Glu Ile Pro 
    130                 135                 140                 


Val Val Gln Ser Ile Pro His Pro Cys Tyr Asn Ser Ser Asp Val Glu 
145                 150                 155                 160 


Asp His Asn His Asp Leu Met Leu Leu Gln Leu Arg Asp Gln Ala Ser 
                165                 170                 175     


Leu Gly Ser Lys Val Lys Pro Ile Ser Leu Ala Asp His Cys Thr Gln 
            180                 185                 190         


Pro Gly Gln Lys Cys Thr Val Ser Gly Trp Gly Thr Val Thr Ser Pro 
        195                 200                 205             


Arg Glu Asn Phe Pro Asp Thr Leu Asn Cys Ala Glu Val Lys Ile Phe 
    210                 215                 220                 


Pro Gln Lys Lys Cys Glu Asp Ala Tyr Pro Gly Gln Ile Thr Asp Gly 
225                 230                 235                 240 


Met Val Cys Ala Gly Ser Ser Lys Gly Ala Asp Thr Cys Gln Gly Asp 
                245                 250                 255     


Ser Gly Gly Pro Leu Val Cys Asp Gly Ala Leu Gln Gly Ile Thr Ser 
            260                 265                 270         


Trp Gly Ser Asp Pro Cys Gly Arg Ser Asp Lys Pro Gly Val Tyr Thr 
        275                 280                 285             


Asn Ile Cys Arg Tyr Leu Asp Trp Ile Lys Lys Ile Ile Gly Ser Lys 
    290                 295                 300                 


Gly 
305 


<210>  7575
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  7575

Met Gly Arg Pro Arg Pro Arg Ala Ala Lys Thr Trp Met Phe Leu Leu 
1               5                   10                  15      


Leu Leu Gly Gly Ala Trp Ala Glu Asn Phe Pro Asp Thr Leu Asn Cys 
            20                  25                  30          


Ala Glu Val Lys Ile Phe Pro Gln Lys Lys Cys Glu Asp Ala Tyr Pro 
        35                  40                  45              


Gly Gln Ile Thr Asp Gly Met Val Cys Ala Gly Ser Ser Lys Gly Ala 
    50                  55                  60                  


Asp Thr Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Asp Gly Ala 
65                  70                  75                  80  


Leu Gln Gly Ile Thr Ser Trp Gly Ser Asp Pro Cys Gly Arg Ser Asp 
                85                  90                  95      


Lys Pro Gly Val Tyr Thr Asn Ile Cys Arg Tyr Leu Asp Trp Ile Lys 
            100                 105                 110         


Lys Ile Ile Gly Ser Lys Gly 
        115                 


<210>  7576
<211>  97
<212>  PRT
<213>  Homo Sapiens

<400>  7576

Met Gly Arg Pro Arg Pro Arg Ala Ala Lys Thr Trp Met Phe Leu Leu 
1               5                   10                  15      


Leu Leu Gly Gly Ala Trp Ala Gly His Ser Arg Ala Gln Glu Asp Lys 
            20                  25                  30          


Val Leu Gly Gly His Glu Cys Gln Pro His Ser Gln Pro Trp Gln Ala 
        35                  40                  45              


Ala Leu Phe Gln Gly Gln Gln Leu Leu Cys Gly Gly Val Leu Val Gly 
    50                  55                  60                  


Gly Asn Trp Val Leu Thr Ala Ala His Cys Lys Lys Pro Lys Tyr Thr 
65                  70                  75                  80  


Val Arg Leu Gly Asp His Ser Leu Gln Asn Lys Asp Gly Pro Glu Gln 
                85                  90                  95      


Glu 
    


<210>  7577
<211>  260
<212>  PRT
<213>  Homo Sapiens

<400>  7577

Met Gly Arg Pro Arg Pro Arg Ala Ala Lys Thr Trp Met Phe Leu Leu 
1               5                   10                  15      


Leu Leu Gly Gly Ala Trp Ala Gly His Ser Arg Ala Gln Glu Asp Lys 
            20                  25                  30          


Val Leu Gly Gly His Glu Cys Gln Pro His Ser Gln Pro Trp Gln Ala 
        35                  40                  45              


Ala Leu Phe Gln Gly Gln Gln Leu Leu Cys Gly Gly Val Leu Val Gly 
    50                  55                  60                  


Gly Asn Trp Val Leu Thr Ala Ala His Cys Lys Lys Pro Lys Tyr Thr 
65                  70                  75                  80  


Val Arg Leu Gly Asp His Ser Leu Gln Asn Lys Asp Gly Pro Glu Gln 
                85                  90                  95      


Glu Ile Pro Val Val Gln Ser Ile Pro His Pro Cys Tyr Asn Ser Ser 
            100                 105                 110         


Asp Val Glu Asp His Asn His Asp Leu Met Leu Leu Gln Leu Arg Asp 
        115                 120                 125             


Gln Ala Ser Leu Gly Ser Lys Val Lys Pro Ile Ser Leu Ala Asp His 
    130                 135                 140                 


Cys Thr Gln Pro Gly Gln Lys Cys Thr Val Ser Gly Trp Gly Thr Val 
145                 150                 155                 160 


Thr Ser Pro Arg Glu Asn Phe Pro Asp Thr Leu Asn Cys Ala Glu Val 
                165                 170                 175     


Lys Ile Phe Pro Gln Lys Lys Cys Glu Asp Ala Tyr Pro Gly Gln Ile 
            180                 185                 190         


Thr Asp Gly Met Val Cys Ala Gly Ser Ser Lys Gly Ala Asp Thr Cys 
        195                 200                 205             


Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Asp Gly Ala Leu Gln Gly 
    210                 215                 220                 


Ile Thr Ser Trp Gly Ser Asp Pro Cys Gly Arg Ser Asp Lys Pro Gly 
225                 230                 235                 240 


Val Tyr Thr Asn Ile Cys Arg Tyr Leu Asp Trp Ile Lys Lys Ile Ile 
                245                 250                 255     


Gly Ser Lys Gly 
            260 


<210>  7578
<211>  32
<212>  PRT
<213>  Homo Sapiens

<400>  7578

Met Gly Arg Pro Arg Pro Arg Ala Ala Lys Thr Trp Met Phe Leu Leu 
1               5                   10                  15      


Leu Leu Gly Gly Ala Trp Ala Gly Arg Phe Trp Arg Pro Pro Gly Val 
            20                  25                  30          


<210>  7579
<211>  32
<212>  PRT
<213>  Homo Sapiens

<400>  7579

Met Gly Arg Pro Arg Pro Arg Ala Ala Lys Thr Trp Met Phe Leu Leu 
1               5                   10                  15      


Leu Leu Gly Gly Ala Trp Ala Gly Arg Phe Trp Arg Pro Pro Gly Val 
            20                  25                  30          


<210>  7580
<211>  139
<212>  PRT
<213>  Homo Sapiens

<400>  7580

Met Leu Leu Gln Leu Arg Asp Gln Ala Ser Leu Gly Ser Lys Val Lys 
1               5                   10                  15      


Pro Ile Ser Leu Ala Asp His Cys Thr Gln Pro Gly Gln Lys Cys Thr 
            20                  25                  30          


Val Ser Gly Trp Gly Thr Val Thr Ser Pro Arg Glu Asn Phe Pro Asp 
        35                  40                  45              


Thr Leu Asn Cys Ala Glu Val Lys Ile Phe Pro Gln Lys Lys Cys Glu 
    50                  55                  60                  


Asp Ala Tyr Pro Gly Gln Ile Thr Asp Gly Met Val Cys Ala Gly Ser 
65                  70                  75                  80  


Ser Lys Gly Ala Asp Thr Cys Gln Gly Asp Ser Gly Gly Pro Leu Val 
                85                  90                  95      


Cys Asp Gly Ala Leu Gln Gly Ile Thr Ser Trp Gly Ser Asp Pro Cys 
            100                 105                 110         


Gly Arg Ser Asp Lys Pro Gly Val Tyr Thr Asn Ile Cys Arg Tyr Leu 
        115                 120                 125             


Asp Trp Ile Lys Lys Ile Ile Gly Ser Lys Gly 
    130                 135                 


<210>  7581
<211>  54
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7581

Xaa Leu Leu Leu Leu Gly Gly Ala Trp Ala Gly Asn Thr Gln Tyr Ala 
1               5                   10                  15      


Trp Glu Thr Thr Ala Tyr Arg Ile Lys Met Ala Gln Ser Lys Lys Tyr 
            20                  25                  30          


Leu Trp Phe Ser Pro Ser His Thr Pro Ala Thr Thr Ala Ala Met Trp 
        35                  40                  45              


Arg Thr Thr Thr Met Ile 
    50                  


<210>  7582
<211>  250
<212>  PRT
<213>  Homo Sapiens

<400>  7582

Met Lys Leu Gly Leu Leu Cys Ala Leu Leu Ser Leu Leu Ala Gly His 
1               5                   10                  15      


Gly Trp Ala Asp Thr Arg Ala Ile Gly Ala Glu Glu Cys Arg Pro Asn 
            20                  25                  30          


Ser Gln Pro Trp Gln Ala Gly Leu Phe His Leu Thr Arg Leu Phe Cys 
        35                  40                  45              


Gly Ala Thr Leu Ile Ser Asp Arg Trp Leu Leu Thr Ala Ala His Cys 
    50                  55                  60                  


Arg Lys Pro Tyr Leu Trp Val Arg Leu Gly Glu His His Leu Trp Lys 
65                  70                  75                  80  


Trp Glu Gly Pro Glu Gln Leu Phe Arg Val Thr Asp Phe Phe Pro His 
                85                  90                  95      


Pro Gly Phe Asn Lys Asp Leu Ser Ala Asn Asp His Asn Asp Asp Ile 
            100                 105                 110         


Met Leu Ile Arg Leu Pro Arg Gln Ala Arg Leu Ser Pro Ala Val Gln 
        115                 120                 125             


Pro Leu Asn Leu Ser Gln Thr Cys Val Ser Pro Gly Met Gln Cys Leu 
    130                 135                 140                 


Ile Ser Gly Trp Gly Ala Val Ser Ser Pro Lys Ala Leu Phe Pro Val 
145                 150                 155                 160 


Thr Leu Gln Cys Ala Asn Ile Ser Ile Leu Glu Asn Lys Leu Cys His 
                165                 170                 175     


Trp Ala Tyr Pro Gly His Ile Ser Asp Ser Met Leu Cys Ala Gly Leu 
            180                 185                 190         


Trp Glu Gly Gly Arg Gly Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu 
        195                 200                 205             


Val Cys Asn Gly Thr Leu Ala Gly Val Val Ser Gly Gly Ala Glu Pro 
    210                 215                 220                 


Cys Ser Arg Pro Arg Arg Pro Ala Val Tyr Thr Ser Val Cys His Tyr 
225                 230                 235                 240 


Leu Asp Trp Ile Gln Glu Ile Met Glu Asn 
                245                 250 


<210>  7583
<211>  61
<212>  PRT
<213>  Homo Sapiens

<400>  7583

Met Lys Leu Gly Leu Leu Cys Ala Leu Leu Ser Leu Leu Ala Gly Ile 
1               5                   10                  15      


Cys Gly Ser Ala Leu Glu Ser Thr Thr Ser Gly Asn Gly Arg Val Arg 
            20                  25                  30          


Ser Ser Cys Ser Gly Leu Arg Thr Ser Ser Pro Thr Leu Ala Ser Thr 
        35                  40                  45              


Arg Thr Ser Ala Pro Met Thr Thr Met Met Thr Ser Cys 
    50                  55                  60      


<210>  7584
<211>  148
<212>  PRT
<213>  Homo Sapiens

<400>  7584

Met Ile Leu Phe Lys Gln Ala Thr Tyr Phe Ile Ser Leu Phe Ala Thr 
1               5                   10                  15      


Val Ser Cys Gly Cys Leu Thr Gln Leu Tyr Glu Asn Ala Phe Phe Arg 
            20                  25                  30          


Gly Gly Asp Val Ala Ser Met Tyr Thr Pro Asn Ala Gln Tyr Cys Gln 
        35                  40                  45              


Met Arg Cys Thr Phe His Pro Arg Cys Leu Leu Phe Ser Phe Leu Pro 
    50                  55                  60                  


Ala Ser Ser Ile Asn Asp Met Glu Lys Arg Phe Gly Cys Phe Leu Lys 
65                  70                  75                  80  


Asp Ser Val Thr Gly Thr Leu Pro Lys Val His Arg Thr Gly Ala Val 
                85                  90                  95      


Ser Gly His Ser Leu Lys Gln Cys Gly His Gln Ile Ser Ala Cys His 
            100                 105                 110         


Arg Asp Ile Tyr Lys Gly Val Asp Met Arg Gly Val Asn Phe Asn Val 
        115                 120                 125             


Ser Lys Val Ser Ser Val Glu Glu Cys Gln Lys Arg Cys Thr Ser Asn 
    130                 135                 140                 


Ile Arg Cys Gln 
145             


<210>  7585
<211>  638
<212>  PRT
<213>  Homo Sapiens

<400>  7585

Met Ile Leu Phe Lys Gln Ala Thr Tyr Phe Ile Ser Leu Phe Ala Thr 
1               5                   10                  15      


Val Ser Cys Gly Cys Leu Thr Gln Leu Tyr Glu Asn Ala Phe Phe Arg 
            20                  25                  30          


Gly Gly Asp Val Ala Ser Met Tyr Thr Pro Asn Ala Gln Tyr Cys Gln 
        35                  40                  45              


Met Arg Cys Thr Phe His Pro Arg Cys Leu Leu Phe Ser Phe Leu Pro 
    50                  55                  60                  


Ala Ser Ser Ile Asn Asp Met Glu Lys Arg Phe Gly Cys Phe Leu Lys 
65                  70                  75                  80  


Asp Ser Val Thr Gly Thr Leu Pro Lys Val His Arg Thr Gly Ala Val 
                85                  90                  95      


Ser Gly His Ser Leu Lys Gln Cys Gly His Gln Ile Ser Ala Cys His 
            100                 105                 110         


Arg Asp Ile Tyr Lys Gly Val Asp Met Arg Gly Val Asn Phe Asn Val 
        115                 120                 125             


Ser Lys Val Ser Ser Val Glu Glu Cys Gln Lys Arg Cys Thr Ser Asn 
    130                 135                 140                 


Ile Arg Cys Gln Phe Phe Ser Tyr Ala Thr Gln Thr Phe His Lys Ala 
145                 150                 155                 160 


Glu Tyr Arg Asn Asn Cys Leu Leu Lys Tyr Ser Pro Gly Gly Thr Pro 
                165                 170                 175     


Thr Ala Ile Lys Val Leu Ser Asn Val Glu Ser Gly Phe Ser Leu Lys 
            180                 185                 190         


Pro Cys Ala Leu Ser Glu Ile Gly Cys His Met Asn Ile Phe Gln His 
        195                 200                 205             


Leu Ala Phe Ser Asp Val Asp Val Ala Arg Val Leu Thr Pro Asp Ala 
    210                 215                 220                 


Phe Val Cys Arg Thr Ile Cys Thr Tyr His Pro Asn Cys Leu Phe Phe 
225                 230                 235                 240 


Thr Phe Tyr Thr Asn Val Trp Lys Ile Glu Ser Gln Arg Asn Val Cys 
                245                 250                 255     


Leu Leu Lys Thr Ser Glu Ser Gly Thr Pro Ser Ser Ser Thr Pro Gln 
            260                 265                 270         


Glu Asn Thr Ile Ser Gly Tyr Ser Leu Leu Thr Cys Lys Arg Thr Leu 
        275                 280                 285             


Pro Glu Pro Cys His Ser Lys Ile Tyr Pro Gly Val Asp Phe Gly Gly 
    290                 295                 300                 


Glu Glu Leu Asn Val Thr Phe Val Lys Gly Val Asn Val Cys Gln Glu 
305                 310                 315                 320 


Thr Cys Thr Lys Met Ile Arg Cys Gln Phe Phe Thr Tyr Ser Leu Leu 
                325                 330                 335     


Pro Glu Asp Cys Lys Glu Glu Lys Cys Lys Cys Phe Leu Arg Leu Ser 
            340                 345                 350         


Met Asp Gly Ser Pro Thr Arg Ile Ala Tyr Gly Thr Gln Gly Ser Ser 
        355                 360                 365             


Gly Tyr Ser Leu Arg Leu Cys Asn Thr Gly Asp Asn Ser Val Cys Thr 
    370                 375                 380                 


Thr Lys Thr Ser Thr Arg Ile Val Gly Gly Thr Asn Ser Ser Trp Gly 
385                 390                 395                 400 


Glu Trp Pro Trp Gln Val Ser Leu Gln Val Lys Leu Thr Ala Gln Arg 
                405                 410                 415     


His Leu Cys Gly Gly Ser Leu Ile Gly His Gln Trp Val Leu Thr Ala 
            420                 425                 430         


Ala His Cys Phe Asp Gly Leu Pro Leu Gln Asp Val Trp Arg Ile Tyr 
        435                 440                 445             


Ser Gly Ile Leu Asn Leu Ser Asp Ile Thr Lys Asp Thr Pro Phe Ser 
    450                 455                 460                 


Gln Ile Lys Glu Ile Ile Ile His Gln Asn Tyr Lys Val Ser Glu Gly 
465                 470                 475                 480 


Asn His Asp Ile Ala Leu Ile Lys Leu Gln Ala Pro Leu Asn Tyr Thr 
                485                 490                 495     


Glu Phe Gln Lys Pro Ile Cys Leu Pro Ser Lys Gly Asp Thr Ser Thr 
            500                 505                 510         


Ile Tyr Thr Asn Cys Trp Val Thr Gly Trp Gly Phe Ser Lys Glu Lys 
        515                 520                 525             


Gly Glu Ile Gln Asn Ile Leu Gln Lys Val Asn Ile Pro Leu Val Thr 
    530                 535                 540                 


Asn Glu Glu Cys Gln Lys Arg Tyr Gln Asp Tyr Lys Ile Thr Gln Arg 
545                 550                 555                 560 


Met Val Cys Ala Gly Tyr Lys Glu Gly Gly Lys Asp Ala Cys Lys Gly 
                565                 570                 575     


Asp Ser Gly Gly Pro Leu Val Cys Lys His Asn Gly Met Trp Arg Leu 
            580                 585                 590         


Val Gly Ile Thr Ser Trp Gly Glu Gly Cys Ala Arg Arg Glu Gln Pro 
        595                 600                 605             


Gly Val Tyr Thr Lys Val Ala Glu Tyr Met Asp Trp Ile Leu Glu Lys 
    610                 615                 620                 


Thr Gln Ser Ser Asp Gly Lys Ala Gln Met Gln Ser Pro Ala 
625                 630                 635             


<210>  7586
<211>  141
<212>  PRT
<213>  Homo Sapiens

<400>  7586

Met Tyr Thr Pro Asn Ala Gln Tyr Cys Gln Met Arg Cys Thr Phe His 
1               5                   10                  15      


Pro Arg Cys Leu Leu Phe Ser Phe Leu Pro Ala Ser Ser Ile Asn Asp 
            20                  25                  30          


Met Glu Lys Arg Phe Gly Cys Phe Leu Lys Asp Ser Val Thr Gly Thr 
        35                  40                  45              


Leu Pro Lys Val His Arg Thr Gly Ala Val Ser Gly His Ser Leu Lys 
    50                  55                  60                  


Gln Cys Gly His Gln Ile Ser Ala Cys His Arg Asp Ile Tyr Lys Gly 
65                  70                  75                  80  


Val Asp Met Arg Gly Val Asn Phe Asn Val Ser Lys Val Ser Ser Val 
                85                  90                  95      


Glu Glu Cys Gln Lys Arg Cys Thr Ser Asn Ile Arg Cys Gln Phe Phe 
            100                 105                 110         


Ser Tyr Ala Thr Gln Thr Phe His Lys Ala Glu Tyr Arg Asn Asn Cys 
        115                 120                 125             


Leu Leu Lys Tyr Ser Pro Gly Gly Thr Pro Thr Ala Ile 
    130                 135                 140     


<210>  7587
<211>  514
<212>  PRT
<213>  Homo Sapiens

<400>  7587

Met Tyr Thr Pro Asn Ala Gln Tyr Cys Gln Met Arg Cys Thr Phe His 
1               5                   10                  15      


Pro Arg Cys Leu Leu Phe Ser Phe Leu Pro Ala Ser Ser Ile Asn Asp 
            20                  25                  30          


Met Glu Lys Arg Phe Gly Cys Phe Leu Lys Asp Ser Val Thr Gly Thr 
        35                  40                  45              


Leu Pro Lys Val His Arg Thr Gly Ala Val Ser Gly His Ser Leu Lys 
    50                  55                  60                  


Gln Cys Gly His Gln Ile Ser Ala Cys His Arg Asp Ile Tyr Lys Gly 
65                  70                  75                  80  


Val Asp Met Arg Gly Val Asn Phe Asn Val Ser Lys Val Ser Ser Val 
                85                  90                  95      


Glu Glu Cys Gln Lys Arg Cys Thr Ser Asn Ile Arg Cys Gln Phe Phe 
            100                 105                 110         


Ser Tyr Ala Thr Gln Thr Phe His Lys Ala Glu Tyr Arg Asn Asn Cys 
        115                 120                 125             


Leu Leu Lys Tyr Ser Pro Gly Gly Thr Pro Thr Ala Ile Lys Val Leu 
    130                 135                 140                 


Ser Asn Val Glu Ser Gly Phe Ser Leu Lys Pro Cys Ala Leu Ser Glu 
145                 150                 155                 160 


Ile Gly Cys His Met Asn Ile Phe Gln His Leu Ala Phe Ser Asp Val 
                165                 170                 175     


Asp Val Ala Arg Val Leu Thr Pro Asp Ala Phe Val Cys Arg Thr Ile 
            180                 185                 190         


Cys Thr Tyr His Pro Asn Cys Leu Phe Phe Thr Phe Tyr Thr Asn Val 
        195                 200                 205             


Trp Lys Ile Glu Ser Gln Arg Asn Val Cys Leu Leu Lys Thr Ser Glu 
    210                 215                 220                 


Ser Gly Thr Pro Ser Ser Ser Thr Pro Gln Glu Asn Thr Ile Ser Gly 
225                 230                 235                 240 


Tyr Ser Leu Leu Thr Cys Lys Arg Thr Leu Pro Glu Pro Cys His Ser 
                245                 250                 255     


Lys Ile Tyr Pro Gly Val Asp Phe Gly Gly Glu Glu Leu Asn Val Thr 
            260                 265                 270         


Phe Val Lys Gly Val Asn Val Cys Gln Glu Thr Cys Thr Lys Met Ile 
        275                 280                 285             


Arg Cys Gln Phe Phe Thr Tyr Ser Leu Leu Pro Glu Asp Cys Lys Glu 
    290                 295                 300                 


Glu Lys Cys Lys Cys Phe Leu Arg Leu Ser Met Asp Gly Ser Pro Thr 
305                 310                 315                 320 


Arg Ile Ala Tyr Gly Thr Gln Gly Ser Ser Gly Tyr Ser Leu Arg Leu 
                325                 330                 335     


Cys Asn Thr Gly Asp Asn Ser Val Cys Thr Thr Lys Thr Ser Thr Arg 
            340                 345                 350         


Ile Val Gly Gly Thr Asn Ser Ser Trp Gly Glu Trp Pro Trp Gln Val 
        355                 360                 365             


Ser Leu Gln Val Lys Leu Thr Ala Gln Arg His Leu Cys Gly Gly Ser 
    370                 375                 380                 


Leu Ile Gly His Gln Trp Val Leu Thr Ala Ala His Cys Phe Asp Gly 
385                 390                 395                 400 


Leu Pro Leu Gln Asp Val Trp Arg Ile Tyr Ser Gly Ile Leu Asn Leu 
                405                 410                 415     


Ser Asp Ile Thr Lys Asp Thr Pro Phe Ser Gln Ile Lys Glu Ile Ile 
            420                 425                 430         


Ile His Gln Asn Tyr Lys Val Ser Glu Gly Asn His Asp Ile Ala Leu 
        435                 440                 445             


Ile Lys Leu Gln Ala Pro Leu Asn Tyr Thr Glu Phe Gln Lys Pro Ile 
    450                 455                 460                 


Cys Leu Pro Ser Lys Gly Asp Thr Ser Thr Ile Tyr Thr Asn Cys Trp 
465                 470                 475                 480 


Val Thr Gly Trp Gly Phe Ser Lys Glu Lys Gly Arg Phe Arg Trp Ser 
                485                 490                 495     


Leu Ser Leu Gln Thr Gln Trp Asn Val Ala Phe Gly Gly His His Gln 
            500                 505                 510         


Leu Gly 
        


<210>  7588
<211>  686
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7588

Xaa Ser Glu Asp Cys Glu Val Ala Gly Tyr Arg Val Leu Lys Gly Thr 
1               5                   10                  15      


Glu Ala Val Ile Ile Pro Tyr Ala Leu His Arg Asp Pro Arg Tyr Phe 
            20                  25                  30          


Pro Asn Pro Glu Glu Phe Gln Pro Glu Arg Phe Phe Pro Glu Asn Ala 
        35                  40                  45              


Gln Gly Arg His Pro Tyr Ala Tyr Val Pro Phe Ser Ala Gly Pro Arg 
    50                  55                  60                  


Asn Cys Ile Gly Cys Leu Thr Gln Leu Tyr Glu Asn Ala Phe Phe Arg 
65                  70                  75                  80  


Gly Gly Asp Val Ala Ser Met Tyr Thr Pro Asn Ala Gln Tyr Cys Gln 
                85                  90                  95      


Met Arg Cys Thr Phe His Pro Arg Cys Leu Leu Phe Ser Phe Leu Pro 
            100                 105                 110         


Ala Ser Ser Ile Asn Asp Met Glu Lys Arg Phe Gly Cys Phe Leu Lys 
        115                 120                 125             


Asp Ser Val Thr Gly Thr Leu Pro Lys Val His Arg Thr Gly Ala Val 
    130                 135                 140                 


Ser Gly His Ser Leu Lys Gln Cys Gly His Gln Ile Ser Ala Cys His 
145                 150                 155                 160 


Arg Asp Ile Tyr Lys Gly Val Asp Met Arg Gly Val Asn Phe Asn Val 
                165                 170                 175     


Ser Lys Val Ser Ser Val Glu Glu Cys Gln Lys Arg Cys Thr Ser Asn 
            180                 185                 190         


Ile Arg Cys Gln Phe Phe Ser Tyr Ala Thr Gln Thr Phe His Lys Ala 
        195                 200                 205             


Glu Tyr Arg Asn Asn Cys Leu Leu Lys Tyr Ser Pro Gly Gly Thr Pro 
    210                 215                 220                 


Thr Ala Ile Lys Val Leu Ser Asn Val Glu Ser Gly Phe Ser Leu Lys 
225                 230                 235                 240 


Pro Cys Ala Leu Ser Glu Ile Gly Cys His Met Asn Ile Phe Gln His 
                245                 250                 255     


Leu Ala Phe Ser Asp Val Asp Val Ala Arg Val Leu Thr Pro Asp Ala 
            260                 265                 270         


Phe Val Cys Arg Thr Ile Cys Thr Tyr His Pro Asn Cys Leu Phe Phe 
        275                 280                 285             


Thr Phe Tyr Thr Asn Val Trp Lys Ile Glu Ser Gln Arg Asn Val Cys 
    290                 295                 300                 


Leu Leu Lys Thr Ser Glu Ser Gly Thr Pro Ser Ser Ser Thr Pro Gln 
305                 310                 315                 320 


Glu Asn Thr Ile Ser Gly Tyr Ser Leu Leu Thr Cys Lys Arg Thr Leu 
                325                 330                 335     


Pro Glu Pro Cys His Ser Lys Ile Tyr Pro Gly Val Asp Phe Gly Gly 
            340                 345                 350         


Glu Glu Leu Asn Val Thr Phe Val Lys Gly Val Asn Val Cys Gln Glu 
        355                 360                 365             


Thr Cys Thr Lys Met Ile Arg Cys Gln Phe Phe Thr Tyr Ser Leu Leu 
    370                 375                 380                 


Pro Glu Asp Cys Lys Glu Glu Lys Cys Lys Cys Phe Leu Arg Leu Ser 
385                 390                 395                 400 


Met Asp Gly Ser Pro Thr Arg Ile Ala Tyr Gly Thr Gln Gly Ser Ser 
                405                 410                 415     


Gly Tyr Ser Leu Arg Leu Cys Asn Thr Gly Asp Asn Ser Val Cys Thr 
            420                 425                 430         


Thr Lys Thr Ser Thr Arg Ile Val Gly Gly Thr Asn Ser Ser Trp Gly 
        435                 440                 445             


Glu Trp Pro Trp Gln Val Ser Leu Gln Val Lys Leu Thr Ala Gln Arg 
    450                 455                 460                 


His Leu Cys Gly Gly Ser Leu Ile Gly His Gln Trp Val Leu Thr Ala 
465                 470                 475                 480 


Ala His Cys Phe Asp Gly Leu Pro Leu Gln Asp Val Trp Arg Ile Tyr 
                485                 490                 495     


Ser Gly Ile Leu Asn Leu Ser Asp Ile Thr Lys Asp Thr Pro Phe Ser 
            500                 505                 510         


Gln Ile Lys Glu Ile Ile Ile His Gln Asn Tyr Lys Val Ser Glu Gly 
        515                 520                 525             


Asn His Asp Ile Ala Leu Ile Lys Leu Gln Ala Pro Leu Asn Tyr Thr 
    530                 535                 540                 


Glu Phe Gln Lys Pro Ile Cys Leu Pro Ser Lys Gly Asp Thr Ser Thr 
545                 550                 555                 560 


Ile Tyr Thr Asn Cys Trp Val Thr Gly Trp Gly Phe Ser Lys Glu Lys 
                565                 570                 575     


Gly Glu Ile Gln Asn Ile Leu Gln Lys Val Asn Ile Pro Leu Val Thr 
            580                 585                 590         


Asn Glu Glu Cys Gln Lys Arg Tyr Gln Asp Tyr Lys Ile Thr Gln Arg 
        595                 600                 605             


Met Val Cys Ala Gly Tyr Lys Glu Gly Gly Lys Asp Ala Cys Lys Gly 
    610                 615                 620                 


Asp Ser Gly Gly Pro Leu Val Cys Lys His Asn Gly Met Trp Arg Leu 
625                 630                 635                 640 


Val Gly Ile Thr Ser Trp Gly Glu Gly Cys Ala Arg Arg Glu Gln Pro 
                645                 650                 655     


Gly Val Tyr Thr Lys Val Ala Glu Tyr Met Asp Trp Ile Leu Glu Lys 
            660                 665                 670         


Thr Gln Ser Ser Asp Gly Lys Ala Gln Met Gln Ser Pro Ala 
        675                 680                 685     


<210>  7589
<211>  91
<212>  PRT
<213>  Homo Sapiens

<400>  7589

Met Ala Arg Gly Glu Arg Ile Tyr Arg Ala Val Lys Asp Leu Phe Leu 
1               5                   10                  15      


His Glu Pro Glu Gln Met Leu Trp Asn Ala Phe Pro Pro Ser Gly Arg 
            20                  25                  30          


Glu Leu Ser Tyr Thr Ser Arg Ser Gln Met Pro Gly Glu Thr Ile Ser 
        35                  40                  45              


Arg Asn Leu Gln Glu Thr Arg Arg Glu Lys Lys Cys Trp Glu Arg Ser 
    50                  55                  60                  


Thr Glu Arg His Glu Val Arg Gly Thr Glu Asp Gln Arg Arg Gln Glu 
65                  70                  75                  80  


Arg Ser Pro Gly Thr Phe Ser Lys Pro Lys Ile 
                85                  90      


<210>  7590
<211>  352
<212>  PRT
<213>  Homo Sapiens

<400>  7590

Met Ala Arg Gly Arg Lys Met Ser Lys Pro Arg Ala Val Glu Ala Ala 
1               5                   10                  15      


Ala Ala Ala Ala Ala Val Ala Ala Thr Ala Pro Gly Pro Glu Met Val 
            20                  25                  30          


Glu Arg Arg Gly Pro Gly Arg Pro Arg Thr Asp Gly Glu Asn Val Phe 
        35                  40                  45              


Thr Gly Gln Ser Lys Ile Tyr Ser Tyr Met Ser Pro Asn Lys Cys Ser 
    50                  55                  60                  


Gly Met Arg Phe Pro Leu Gln Glu Glu Asn Ser Val Thr His His Glu 
65                  70                  75                  80  


Val Lys Cys Gln Gly Lys Pro Leu Ala Gly Ile Tyr Arg Lys Arg Glu 
                85                  90                  95      


Glu Lys Arg Asn Ala Gly Asn Ala Val Arg Ser Ala Met Lys Ser Glu 
            100                 105                 110         


Glu Gln Lys Ile Lys Asp Ala Arg Lys Gly Pro Leu Val Pro Phe Pro 
        115                 120                 125             


Asn Gln Lys Ser Glu Ala Ala Glu Pro Pro Lys Thr Pro Pro Ser Ser 
    130                 135                 140                 


Cys Asp Ser Thr Asn Ala Ala Ile Ala Lys Gln Ala Leu Lys Lys Pro 
145                 150                 155                 160 


Ile Lys Gly Lys Gln Ala Pro Arg Lys Lys Ala Gln Gly Lys Thr Gln 
                165                 170                 175     


Gln Asn Arg Lys Leu Thr Asp Phe Tyr Pro Val Arg Arg Ser Ser Arg 
            180                 185                 190         


Lys Ser Lys Ala Glu Leu Gln Ser Glu Glu Arg Lys Arg Ile Asp Glu 
        195                 200                 205             


Leu Ile Glu Ser Gly Lys Glu Glu Gly Met Lys Ile Asp Leu Ile Asp 
    210                 215                 220                 


Gly Lys Gly Arg Gly Val Ile Ala Thr Lys Gln Phe Ser Arg Gly Asp 
225                 230                 235                 240 


Phe Val Val Glu Tyr His Gly Asp Leu Ile Glu Ile Thr Asp Ala Lys 
                245                 250                 255     


Lys Arg Glu Ala Leu Tyr Ala Gln Asp Pro Ser Thr Gly Cys Tyr Met 
            260                 265                 270         


Tyr Tyr Phe Gln Tyr Leu Ser Lys Thr Tyr Cys Val Asp Ala Thr Arg 
        275                 280                 285             


Glu Thr Asn Arg Leu Gly Arg Leu Ile Asn His Ser Lys Cys Gly Asn 
    290                 295                 300                 


Cys Gln Thr Lys Leu His Asp Ile Asp Gly Val Pro His Leu Ile Leu 
305                 310                 315                 320 


Ile Ala Ser Arg Asp Ile Ala Ala Gly Glu Glu Leu Leu Tyr Asp Tyr 
                325                 330                 335     


Gly Asp Arg Ser Lys Ala Ser Ile Glu Ala His Pro Trp Leu Lys His 
            340                 345                 350         


<210>  7591
<211>  299
<212>  PRT
<213>  Homo Sapiens

<400>  7591

Met Arg Trp Leu Trp Leu Leu Leu Phe Pro Asp Ser Pro Val Thr Leu 
1               5                   10                  15      


Arg Glu Val Leu Pro Ser Gln Pro Trp Arg Leu Arg Gly Cys Ser Asp 
            20                  25                  30          


Leu Arg Gly Glu Asn Val Phe Thr Gly Gln Ser Lys Ile Tyr Ser Tyr 
        35                  40                  45              


Met Ser Pro Asn Lys Cys Ser Gly Met Arg Phe Pro Leu Gln Glu Glu 
    50                  55                  60                  


Asn Ser Val Thr His His Glu Val Lys Cys Gln Gly Lys Pro Leu Ala 
65                  70                  75                  80  


Gly Ile Tyr Arg Lys Arg Glu Glu Lys Arg Asn Ala Gly Asn Ala Val 
                85                  90                  95      


Arg Ser Ala Met Lys Ser Glu Glu Gln Lys Ile Lys Asp Ala Arg Lys 
            100                 105                 110         


Gly Pro Leu Val Pro Phe Pro Asn Gln Lys Ser Glu Ala Ala Glu Pro 
        115                 120                 125             


Pro Lys Thr Pro Pro Ser Ser Cys Asp Ser Thr Asn Ala Ala Ile Ala 
    130                 135                 140                 


Lys Gln Ala Leu Lys Lys Pro Ile Lys Gly Lys Gln Ala Pro Arg Lys 
145                 150                 155                 160 


Lys Ala Gln Gly Lys Thr Gln Gln Asn Arg Lys Leu Thr Asp Phe Tyr 
                165                 170                 175     


Pro Val Arg Arg Ser Ser Arg Lys Ser Lys Ala Glu Leu Gln Ser Glu 
            180                 185                 190         


Glu Arg Lys Arg Ile Asp Glu Leu Ile Glu Ser Gly Lys Glu Glu Gly 
        195                 200                 205             


Met Lys Ile Asp Leu Ile Asp Gly Lys Gly Arg Gly Val Ile Ala Thr 
    210                 215                 220                 


Lys Gln Phe Ser Arg Gly Asp Phe Val Val Glu Tyr His Gly Asp Leu 
225                 230                 235                 240 


Ile Glu Ile Thr Asp Ala Lys Lys Arg Glu Ala Leu Tyr Ala Gln Asp 
                245                 250                 255     


Pro Ser Thr Gly Cys Tyr Met Tyr Tyr Phe Gln Tyr Leu Ser Lys Thr 
            260                 265                 270         


Tyr Cys Val Asp Ala Thr Arg Glu Thr Asn Arg Leu Gly Arg Leu Ile 
        275                 280                 285             


Asn His Ser Lys Cys Gly Asn Cys Gln Thr Lys 
    290                 295                 


<210>  7592
<211>  322
<212>  PRT
<213>  Homo Sapiens

<400>  7592

Met Val Glu Arg Arg Gly Pro Gly Arg Pro Arg Thr Asp Gly Glu Asn 
1               5                   10                  15      


Val Phe Thr Gly Gln Ser Lys Ile Tyr Ser Tyr Met Ser Pro Asn Lys 
            20                  25                  30          


Cys Ser Gly Met Arg Phe Pro Leu Gln Glu Glu Asn Ser Val Thr His 
        35                  40                  45              


His Glu Val Lys Cys Gln Gly Lys Pro Leu Ala Gly Ile Tyr Arg Lys 
    50                  55                  60                  


Arg Glu Glu Lys Arg Asn Ala Gly Asn Ala Val Arg Ser Ala Met Lys 
65                  70                  75                  80  


Ser Glu Glu Gln Lys Ile Lys Asp Ala Arg Lys Gly Pro Leu Val Pro 
                85                  90                  95      


Phe Pro Asn Gln Lys Ser Glu Ala Ala Glu Pro Pro Lys Thr Pro Pro 
            100                 105                 110         


Ser Ser Cys Asp Ser Thr Asn Ala Ala Ile Ala Lys Gln Ala Leu Lys 
        115                 120                 125             


Lys Pro Ile Lys Gly Lys Gln Ala Pro Arg Lys Lys Ala Gln Gly Lys 
    130                 135                 140                 


Thr Gln Gln Asn Arg Lys Leu Thr Asp Phe Tyr Pro Val Arg Arg Ser 
145                 150                 155                 160 


Ser Arg Lys Ser Lys Ala Glu Leu Gln Ser Glu Glu Arg Lys Arg Ile 
                165                 170                 175     


Asp Glu Leu Ile Glu Ser Gly Lys Glu Glu Gly Met Lys Ile Asp Leu 
            180                 185                 190         


Ile Asp Gly Lys Gly Arg Gly Val Ile Ala Thr Lys Gln Phe Ser Arg 
        195                 200                 205             


Gly Asp Phe Val Val Glu Tyr His Gly Asp Leu Ile Glu Ile Thr Asp 
    210                 215                 220                 


Ala Lys Lys Arg Glu Ala Leu Tyr Ala Gln Asp Pro Ser Thr Gly Cys 
225                 230                 235                 240 


Tyr Met Tyr Tyr Phe Gln Tyr Leu Ser Lys Thr Tyr Cys Val Asp Ala 
                245                 250                 255     


Thr Arg Glu Thr Asn Arg Leu Gly Arg Leu Ile Asn His Ser Lys Cys 
            260                 265                 270         


Gly Asn Cys Gln Thr Lys Leu His Asp Ile Asp Gly Val Pro His Leu 
        275                 280                 285             


Ile Leu Ile Ala Ser Arg Asp Ile Ala Ala Gly Glu Glu Leu Leu Tyr 
    290                 295                 300                 


Asp Tyr Gly Asp Arg Ser Lys Ala Ser Ile Glu Ala His Pro Trp Leu 
305                 310                 315                 320 


Lys His 
        


<210>  7593
<211>  1749
<212>  PRT
<213>  Homo Sapiens

<400>  7593

Met Gln Ala Met Asp Pro Ala Ala Ala Asp Leu Tyr Glu Glu Asp Gly 
1               5                   10                  15      


Lys Asp Leu Asp Phe Tyr Asp Phe Glu Pro Leu Pro Thr Leu Pro Glu 
            20                  25                  30          


Asp Glu Glu Asn Val Ser Leu Ala Asp Ile Leu Ser Leu Arg Asp Arg 
        35                  40                  45              


Gly Leu Ser Glu Gln Glu Ala Trp Ala Val Cys Leu Glu Cys Ser Leu 
    50                  55                  60                  


Ser Met Arg Ser Val Ala His Ala Ala Ile Phe Gln Ser Leu Cys Ile 
65                  70                  75                  80  


Thr Pro Asp Thr Leu Ala Phe Asn Thr Ser Gly Asn Val Cys Phe Met 
                85                  90                  95      


Glu Gln Leu Ser Asp Asp Pro Glu Gly Ala Phe Val Pro Pro Glu Phe 
            100                 105                 110         


Asp Val Thr Gly Asn Thr Phe Glu Ala His Ile Tyr Ser Leu Gly Ala 
        115                 120                 125             


Thr Leu Lys Ala Ala Leu Glu Tyr Val Ala Glu Pro Thr Leu Glu Pro 
    130                 135                 140                 


Arg Leu Ser Gln Asp Leu Glu Ala Leu Leu Ser Arg Met Gln Ala Glu 
145                 150                 155                 160 


Asp Pro Gly Asp Arg Pro Asp Leu Glu Ser Ile Ile Ala Leu Cys Glu 
                165                 170                 175     


Glu Lys Leu Gln Leu Thr Ser Ser Cys Arg Val Cys Arg Ser Leu Ser 
            180                 185                 190         


Ala Val Gly Arg Arg Val Leu Ser Ile Glu Ser Phe Gly Ala Leu Gln 
        195                 200                 205             


Asp Val Ser Glu Ser Ser Trp Arg Glu Arg Pro Ala Pro Gly Asn Ala 
    210                 215                 220                 


Gly Pro Arg Arg Pro Pro Gly Asp Pro Ser Thr Asp Pro Glu Val Leu 
225                 230                 235                 240 


Pro Thr Pro Glu Gly Pro Glu Ser Glu Thr Ser Arg Gly Pro Arg Ala 
                245                 250                 255     


Ser Pro Thr Lys Ala Leu Leu Ser Thr Pro Val Arg Asn Gly Glu Ser 
            260                 265                 270         


His Ser Arg Glu Gly Leu Ala Gly Leu Val Leu Asp Ala Glu Arg Thr 
        275                 280                 285             


Leu Gly Glu Leu Asp Arg Asp Ala Leu Arg Arg Ser Arg Leu Arg Lys 
    290                 295                 300                 


Val Gln Thr Phe Pro Arg Leu Leu Ser Asp Ser Pro Glu Ala Thr Leu 
305                 310                 315                 320 


Cys Leu Pro Leu Thr Arg Gly Lys Ser Gln Leu Pro Ile Ser Glu Leu 
                325                 330                 335     


Phe Ser Pro Asp Pro Arg Lys Ala Phe Leu Asp Arg Lys Asn Gly Leu 
            340                 345                 350         


Ser Ser Phe Gln Ala Gln Pro Lys Cys Arg Leu Trp Pro Glu Gln Glu 
        355                 360                 365             


Pro Glu His Gln Leu Gly Arg Val Pro Cys Ala Gly Arg Ser Thr Asp 
    370                 375                 380                 


Arg Gly Pro Gly Val Pro Gly Ser Pro Gly Gln Pro Glu Thr Ser His 
385                 390                 395                 400 


Pro Ser Gln Gly Pro Ala Glu Ala Pro Ala Asp Pro Arg Asp Ala Ser 
                405                 410                 415     


Gly Glu Ala Gln Thr Pro Arg Asp Asp Glu Arg Ile Pro Glu Gly Ala 
            420                 425                 430         


Arg Gln Leu Glu Ser Ala Ala Ala Glu Gln Trp Val Ser Leu Gln Asp 
        435                 440                 445             


Leu Leu Ser Gln Leu Gly Arg Pro Phe Arg Glu Tyr Glu Leu Trp Ala 
    450                 455                 460                 


Leu Cys Leu Ala Cys Leu Arg Ala Leu Gln Thr Arg Pro Glu His Pro 
465                 470                 475                 480 


Ala Tyr Leu Cys Leu Asp Ser Val Leu Val Ala Glu Asp Gly Ala Val 
                485                 490                 495     


Leu Phe Gln Pro Pro Pro Ala Asn Gly Ser Tyr Asp Ser Phe Phe Leu 
            500                 505                 510         


Ala Pro Glu Leu Ala Glu Glu Arg Leu Val Thr Glu Lys Ala Ser Val 
        515                 520                 525             


Tyr Cys Val Ala Ala Val Leu Trp Thr Ala Ala Lys Phe Ser Val Pro 
    530                 535                 540                 


Arg Asn His Lys Leu Ala Leu Pro Arg Arg Leu Lys Thr Leu Leu Leu 
545                 550                 555                 560 


Asp Met Ala Arg Arg Ser Ala Pro Glu Arg Pro Ser Ala Ala Glu Ala 
                565                 570                 575     


Ile Lys Val Cys Gly Ser Tyr Leu Leu Gln Arg Gly Met Asp Ser Arg 
            580                 585                 590         


Lys Ile Leu Ala His Leu Arg Ala Ser Ile Cys Gln Val Tyr Gln Glu 
        595                 600                 605             


Glu Glu Thr Ile Ser Leu Gln Asn Ala Phe Ser Val Val Glu Leu Lys 
    610                 615                 620                 


Pro Ser Val Ala Pro Ala Pro Glu Pro Ser Pro Gly Phe Leu Pro Val 
625                 630                 635                 640 


Asn Ser Asp Thr Gly Leu Val Ala Val Pro Gly Pro Val Pro Gly Gln 
                645                 650                 655     


His Pro Cys Gly Glu Glu Ala Thr Gln Leu Pro Ala Ala Phe Thr Ser 
            660                 665                 670         


Glu Ala Thr His Phe Lys Pro Ile Val Leu Ala Gln Asn Ala Ser Val 
        675                 680                 685             


Ala Arg Asp Gln Pro Ala Leu Ala Gln Glu Glu Ser Glu Glu Arg Gly 
    690                 695                 700                 


Gly Gln Arg Glu Gly Glu Gly Glu Glu Lys Leu Ser Leu Glu Ala His 
705                 710                 715                 720 


Ala Gly Ser Pro Ser Leu Lys Thr Pro Asp Gly Pro Val Pro Gly Pro 
                725                 730                 735     


Gly Pro Gln Gly Ala Ala Pro Glu Pro Leu Gly Ala Ser Val Gln Arg 
            740                 745                 750         


Asp Ser Ala Gln Gly Arg Pro Cys Pro Pro Pro Gln Ala Pro Ala Asn 
        755                 760                 765             


Gln Pro Glu Gly Ala Ser Ser Ala Ala Pro Gly Ser Pro Val Pro Ala 
    770                 775                 780                 


Pro Pro Thr Lys Ala Ser Ala Leu Pro Val Glu Gln Gly Pro Ala Glu 
785                 790                 795                 800 


Pro Ile Pro Pro Gly Val Ala Ser Gly Gly Leu Arg Pro Asp Ala Leu 
                805                 810                 815     


Gly Pro Thr Thr Ala His His Gly Pro Arg His Pro Pro Lys Pro Pro 
            820                 825                 830         


Arg Ser Lys Ala Thr Glu Arg Pro Gly Gln Glu Pro Glu Gly Pro Gly 
        835                 840                 845             


Ala Thr Pro Ala Gly Glu Arg Asp Asp Gln Ser Pro Asp Ser Val Pro 
    850                 855                 860                 


Glu Arg Pro Arg Pro Ala Asp Arg Arg Leu Cys Leu Pro Cys Val Asp 
865                 870                 875                 880 


Ala Ser Pro Leu Pro Gly Arg Thr Ala Cys Pro Ser Leu Gln Glu Ala 
                885                 890                 895     


Thr Arg Leu Ile Gln Glu Glu Phe Ala Phe Asp Gly Tyr Leu Asp Asn 
            900                 905                 910         


Gly Leu Glu Ala Leu Ile Met Gly Glu Tyr Ile Phe Ala Leu Lys Asp 
        915                 920                 925             


Leu Thr Phe Ala Thr Phe Cys Gly Ala Ile Ser Glu Lys Phe Cys Asp 
    930                 935                 940                 


Leu Tyr Trp Asp Glu Lys Leu Leu Gln Asn Leu Phe Lys Val Val Asn 
945                 950                 955                 960 


Gly Gln Ala Ser Pro Ser Pro Ser Thr Ala Glu Glu Ala Gly Ser Gln 
                965                 970                 975     


Leu Glu Gly Ser Gln Ser Pro Arg Ser Pro Ser Ser Lys Arg Pro Ser 
            980                 985                 990         


Leu His Arg Leu Gly Lys Glu Lys  Pro Ala Met Ala Arg  Thr Ser Ser 
        995                 1000                 1005             


Arg Ala  Pro Cys Ser Pro Thr  Ser Val Ser Asp Val  Asp Ser Asp 
    1010                 1015                 1020             


Ala Leu  Ser Arg Gly Asn Phe  Glu Val Gly Phe Arg  Pro Gln Arg 
    1025                 1030                 1035             


Ser Val  Lys Ala Glu Arg Ala  Gln Gln Pro Glu Ala  Gly Glu Asp 
    1040                 1045                 1050             


Arg Arg  Pro Ala Gly Gly Ala  Ser Asp Val Glu Ala  Val Thr Arg 
    1055                 1060                 1065             


Leu Ala  Arg Ser Lys Gly Val  Gly Pro Ala Leu Ser  Pro Gly Pro 
    1070                 1075                 1080             


Ala Gly  Phe Gln Ser Cys Ser  Pro Gly Trp Cys Ser  Ala Phe Tyr 
    1085                 1090                 1095             


Glu Ala  Asp Cys Phe Gly Ala  Asp Val His Asn Tyr  Val Lys Asp 
    1100                 1105                 1110             


Leu Gly  Arg Gln Gln Ala Asp  Gly Ala Leu Pro Asp  Ala Gln Ser 
    1115                 1120                 1125             


Pro Glu  Leu Glu Gln Gln Leu  Met Met Glu Lys Arg  Asn Tyr Arg 
    1130                 1135                 1140             


Lys Thr  Leu Lys Phe Tyr Gln  Lys Leu Leu Gln Lys  Glu Lys Arg 
    1145                 1150                 1155             


Asn Lys  Gly Ser Asp Val Lys  Thr Met Leu Ser Lys  Leu Lys Gly 
    1160                 1165                 1170             


Gln Leu  Glu Glu Met Lys Ser  Arg Val Gln Phe Leu  Ser Leu Val 
    1175                 1180                 1185             


Lys Lys  Tyr Leu Gln Val Met  Tyr Ala Glu Arg Trp  Gly Leu Glu 
    1190                 1195                 1200             


Pro Cys  Thr Leu Pro Val Ile  Val Asn Ile Ala Ala  Ala Pro Cys 
    1205                 1210                 1215             


Asp Thr  Leu Asp Phe Ser Pro  Leu Asp Glu Ser Ser  Ser Leu Ile 
    1220                 1225                 1230             


Phe Tyr  Asn Val Asn Lys His  Pro Gly Gly Arg Gln  Lys Ala Arg 
    1235                 1240                 1245             


Ile Leu  Gln Ala Gly Thr Pro  Leu Gly Leu Met Ala  Tyr Leu Tyr 
    1250                 1255                 1260             


Ser Ser  Asp Ala Phe Leu Glu  Gly Tyr Val Gln Gln  Phe Leu Tyr 
    1265                 1270                 1275             


Thr Phe  Arg Tyr Phe Cys Thr  Pro His Asp Phe Leu  His Phe Leu 
    1280                 1285                 1290             


Leu Asp  Arg Ile Asn Ser Thr  Leu Thr Arg Ala His  Gln Asp Pro 
    1295                 1300                 1305             


Thr Ser  Thr Phe Thr Lys Ile  Tyr Arg Arg Ser Leu  Cys Val Leu 
    1310                 1315                 1320             


Gln Ala  Trp Val Glu Asp Cys  Tyr Ala Val Asp Phe  Pro Arg Asn 
    1325                 1330                 1335             


Ser Gly  Leu Leu Gly Lys Leu  Glu Asp Phe Ile Ser  Ser Lys Ile 
    1340                 1345                 1350             


Leu Pro  Leu Asp Gly Ser Ala  Lys His Leu Leu Gly  Leu Leu Glu 
    1355                 1360                 1365             


Val Gly  Met Asp Arg Arg Ala  Glu Gly Asn Pro Arg  Gly Thr Asp 
    1370                 1375                 1380             


Leu Glu  Asn Pro Arg Glu Ala  Glu Glu Asp Ala Arg  Pro Phe Asn 
    1385                 1390                 1395             


Ala Leu  Cys Lys Arg Leu Ser  Glu Asp Gly Ile Ser  Arg Lys Ser 
    1400                 1405                 1410             


Phe Pro  Trp Arg Leu Pro Arg  Gly Asn Gly Leu Val  Leu Pro Pro 
    1415                 1420                 1425             


His Lys  Glu Arg Pro Tyr Thr  Ile Ala Ala Ala Leu  Pro Lys Pro 
    1430                 1435                 1440             


Cys Phe  Leu Glu Asp Phe Tyr  Gly Pro Cys Ala Lys  Thr Ser Glu 
    1445                 1450                 1455             


Lys Gly  Pro Tyr Phe Leu Thr  Glu Tyr Ser Thr His  Gln Leu Phe 
    1460                 1465                 1470             


Ser Gln  Leu Thr Leu Leu Gln  Gln Glu Leu Phe Gln  Lys Cys His 
    1475                 1480                 1485             


Pro Val  His Phe Leu Asn Ser  Arg Ala Leu Gly Val  Met Asp Lys 
    1490                 1495                 1500             


Ser Thr  Ala Ile Pro Lys Ala  Ser Ser Ser Glu Ser  Leu Ser Ala 
    1505                 1510                 1515             


Lys Thr  Cys Ser Leu Phe Leu  Pro Asn Tyr Val Gln  Asp Lys Tyr 
    1520                 1525                 1530             


Leu Leu  Gln Leu Leu Arg Asn  Ala Asp Asp Val Ser  Thr Trp Val 
    1535                 1540                 1545             


Ala Ala  Glu Ile Val Thr Ser  His Thr Ser Lys Leu  Gln Val Asn 
    1550                 1555                 1560             


Leu Leu  Ser Lys Phe Leu Leu  Ile Ala Lys Ser Cys  Tyr Glu Gln 
    1565                 1570                 1575             


Arg Asn  Phe Ala Thr Ala Met  Gln Ile Leu Ser Gly  Leu Glu His 
    1580                 1585                 1590             


Leu Ala  Val Arg Gln Ser Pro  Ala Trp Arg Ile Leu  Pro Ala Lys 
    1595                 1600                 1605             


Ile Ala  Glu Val Met Glu Glu  Leu Lys Ala Val Glu  Val Phe Leu 
    1610                 1615                 1620             


Lys Ser  Asp Ser Leu Cys Leu  Met Glu Gly Arg Arg  Phe Arg Ala 
    1625                 1630                 1635             


Gln Pro  Thr Leu Pro Ser Ala  His Leu Leu Ala Met  His Ile Gln 
    1640                 1645                 1650             


Gln Leu  Glu Thr Gly Gly Phe  Thr Met Thr Asn Gly  Ala His Arg 
    1655                 1660                 1665             


Trp Ser  Lys Leu Arg Asn Ile  Ala Lys Val Val Ser  Gln Val His 
    1670                 1675                 1680             


Ala Phe  Gln Glu Asn Pro Tyr  Thr Phe Ser Pro Asp  Pro Lys Leu 
    1685                 1690                 1695             


Gln Ser  Tyr Leu Lys Gln Arg  Ile Ala Arg Phe Ser  Gly Ala Asp 
    1700                 1705                 1710             


Ile Ser  Thr Leu Ala Ala Asp  Ser Arg Ala Asn Phe  His Gln Val 
    1715                 1720                 1725             


Ser Ser  Glu Lys His Ser Arg  Lys Ile Gln Asp Lys  Leu Arg Arg 
    1730                 1735                 1740             


Met Lys  Ala Thr Phe Gln 
    1745                 


<210>  7594
<211>  1141
<212>  PRT
<213>  Homo Sapiens

<400>  7594

Met Arg Ser Val Ala His Ala Ala Ile Phe Gln Ser Leu Cys Ile Thr 
1               5                   10                  15      


Pro Asp Thr Leu Ala Phe Asn Thr Ser Gly Asn Val Cys Phe Met Glu 
            20                  25                  30          


Gln Leu Ser Asp Asp Pro Glu Gly Ala Phe Val Pro Pro Glu Phe Asp 
        35                  40                  45              


Val Thr Gly Asn Thr Phe Glu Ala His Ile Tyr Ser Leu Gly Ala Thr 
    50                  55                  60                  


Leu Lys Ala Ala Leu Glu Tyr Val Ala Glu Pro Thr Leu Glu Pro Arg 
65                  70                  75                  80  


Leu Ser Gln Asp Leu Glu Ala Leu Leu Ser Arg Met Gln Ala Glu Asp 
                85                  90                  95      


Pro Gly Asp Arg Pro Asp Leu Glu Ser Ile Ile Ala Leu Cys Glu Glu 
            100                 105                 110         


Lys Leu Gln Leu Thr Ser Ser Cys Arg Val Cys Arg Ser Leu Ser Ala 
        115                 120                 125             


Val Gly Arg Arg Val Leu Ser Ile Glu Ser Phe Gly Ala Leu Gln Asp 
    130                 135                 140                 


Val Ser Glu Ser Ser Trp Arg Glu Arg Pro Ala Pro Gly Asn Ala Gly 
145                 150                 155                 160 


Pro Arg Arg Pro Pro Gly Asp Pro Ser Thr Asp Pro Glu Val Leu Pro 
                165                 170                 175     


Thr Pro Glu Gly Pro Glu Ser Glu Thr Ser Arg Gly Pro Arg Ala Ser 
            180                 185                 190         


Pro Thr Lys Ala Leu Leu Ser Thr Pro Val Arg Asn Gly Glu Ser His 
        195                 200                 205             


Ser Arg Glu Gly Leu Ala Gly Leu Val Leu Asp Ala Glu Arg Thr Leu 
    210                 215                 220                 


Gly Glu Leu Asp Arg Asp Ala Leu Arg Arg Ser Arg Leu Arg Lys Val 
225                 230                 235                 240 


Gln Thr Phe Pro Arg Leu Leu Ser Asp Ser Pro Glu Ala Thr Leu Cys 
                245                 250                 255     


Leu Pro Leu Thr Arg Gly Lys Ser Gln Leu Pro Ile Ser Glu Leu Phe 
            260                 265                 270         


Ser Pro Asp Pro Arg Lys Ala Phe Leu Asp Arg Lys Asn Gly Leu Ser 
        275                 280                 285             


Ser Phe Gln Ala Gln Pro Lys Cys Arg Leu Trp Pro Glu Gln Glu Pro 
    290                 295                 300                 


Glu His Gln Leu Gly Arg Val Pro Cys Ala Gly Arg Ser Thr Asp Arg 
305                 310                 315                 320 


Gly Pro Gly Val Pro Gly Ser Pro Gly Gln Pro Glu Thr Ser His Pro 
                325                 330                 335     


Ser Gln Gly Pro Ala Glu Ala Pro Ala Asp Pro Arg Asp Ala Ser Gly 
            340                 345                 350         


Glu Ala Gln Thr Pro Arg Asp Asp Glu Arg Ile Pro Glu Gly Ala Arg 
        355                 360                 365             


Gln Leu Glu Ser Ala Ala Ala Glu Gln Trp Val Ser Leu Gln Asp Leu 
    370                 375                 380                 


Leu Ser Gln Leu Gly Arg Pro Phe Arg Glu Tyr Glu Leu Trp Ala Leu 
385                 390                 395                 400 


Cys Leu Ala Cys Leu Arg Ala Leu Gln Thr Arg Pro Glu His Pro Ala 
                405                 410                 415     


Tyr Leu Cys Leu Asp Ser Val Leu Val Ala Glu Asp Gly Ala Val Leu 
            420                 425                 430         


Phe Gln Pro Pro Pro Ala Asn Gly Ser Tyr Asp Ser Phe Phe Leu Ala 
        435                 440                 445             


Pro Glu Leu Ala Glu Glu Arg Leu Val Thr Glu Lys Ala Ser Val Tyr 
    450                 455                 460                 


Cys Val Ala Ala Val Leu Trp Thr Ala Ala Lys Phe Ser Val Pro Arg 
465                 470                 475                 480 


Asn His Lys Leu Ala Leu Pro Arg Arg Leu Lys Thr Leu Leu Leu Asp 
                485                 490                 495     


Met Ala Arg Arg Ser Ala Pro Glu Arg Pro Ser Ala Ala Glu Ala Ile 
            500                 505                 510         


Lys Val Cys Gly Ser Tyr Leu Leu Gln Arg Gly Met Asp Ser Arg Lys 
        515                 520                 525             


Ile Leu Ala His Leu Arg Ala Ser Ile Cys Gln Val Tyr Gln Glu Glu 
    530                 535                 540                 


Glu Thr Ile Ser Leu Gln Asn Ala Phe Ser Val Val Glu Leu Lys Pro 
545                 550                 555                 560 


Ser Val Ala Pro Ala Pro Glu Pro Ser Pro Gly Phe Leu Pro Val Asn 
                565                 570                 575     


Ser Asp Thr Gly Leu Val Ala Val Pro Gly Pro Val Pro Gly Gln His 
            580                 585                 590         


Pro Cys Gly Glu Glu Ala Thr Gln Leu Pro Ala Ala Phe Thr Ser Glu 
        595                 600                 605             


Ala Thr His Phe Lys Pro Ile Val Leu Ala Gln Asn Ala Ser Val Ala 
    610                 615                 620                 


Arg Asp Gln Pro Ala Leu Ala Gln Glu Glu Ser Glu Glu Arg Gly Gly 
625                 630                 635                 640 


Gln Arg Glu Gly Glu Gly Glu Glu Lys Leu Ser Leu Glu Ala His Ala 
                645                 650                 655     


Gly Ser Pro Ser Leu Lys Thr Pro Asp Gly Pro Val Pro Gly Pro Gly 
            660                 665                 670         


Pro Gln Gly Ala Ala Pro Glu Pro Leu Gly Ala Ser Val Gln Arg Asp 
        675                 680                 685             


Ser Ala Gln Gly Arg Pro Cys Pro Pro Pro Gln Ala Pro Ala Asn Gln 
    690                 695                 700                 


Pro Glu Gly Ala Ser Ser Ala Ala Pro Gly Ser Pro Val Pro Ala Pro 
705                 710                 715                 720 


Pro Thr Lys Ala Ser Ala Leu Pro Val Glu Gln Gly Pro Ala Glu Pro 
                725                 730                 735     


Ile Pro Pro Gly Val Ala Ser Gly Gly Leu Arg Pro Asp Ala Leu Gly 
            740                 745                 750         


Pro Thr Thr Ala His His Gly Pro Arg His Pro Pro Lys Pro Pro Arg 
        755                 760                 765             


Ser Lys Ala Thr Glu Arg Pro Gly Gln Glu Pro Glu Gly Pro Gly Ala 
    770                 775                 780                 


Thr Pro Ala Gly Glu Arg Asp Asp Gln Ser Pro Asp Ser Val Pro Glu 
785                 790                 795                 800 


Arg Pro Arg Pro Ala Asp Arg Arg Leu Cys Leu Pro Cys Val Asp Ala 
                805                 810                 815     


Ser Pro Leu Pro Gly Arg Thr Ala Cys Pro Ser Leu Gln Glu Ala Thr 
            820                 825                 830         


Arg Leu Ile Gln Glu Glu Phe Ala Phe Asp Gly Tyr Leu Asp Asn Gly 
        835                 840                 845             


Leu Glu Ala Leu Ile Met Gly Glu Tyr Ile Phe Ala Leu Lys Asp Leu 
    850                 855                 860                 


Thr Phe Ala Thr Phe Cys Gly Ala Ile Ser Glu Lys Phe Cys Asp Leu 
865                 870                 875                 880 


Tyr Trp Asp Glu Lys Leu Leu Gln Asn Leu Phe Lys Val Val Asn Gly 
                885                 890                 895     


Gln Ala Ser Pro Ser Pro Ser Thr Ala Glu Glu Ala Gly Ser Gln Leu 
            900                 905                 910         


Glu Gly Ser Gln Ser Pro Arg Ser Pro Ser Ser Lys Arg Pro Ser Leu 
        915                 920                 925             


His Arg Leu Gly Lys Glu Lys Pro Ala Met Ala Arg Thr Ser Ser Arg 
    930                 935                 940                 


Ala Pro Cys Ser Pro Thr Ser Val Ser Asp Val Asp Ser Asp Ala Leu 
945                 950                 955                 960 


Ser Arg Gly Asn Phe Glu Val Gly Phe Arg Pro Gln Arg Ser Val Lys 
                965                 970                 975     


Ala Glu Arg Ala Gln Gln Pro Glu Ala Gly Glu Asp Arg Arg Pro Ala 
            980                 985                 990         


Gly Gly Ala Ser Asp Val Glu Ala  Val Thr Arg Leu Ala  Arg Ser Lys 
        995                 1000                 1005             


Gly Val  Gly Pro Ala Leu Ser  Pro Gly Pro Ala Gly  Phe Gln Ser 
    1010                 1015                 1020             


Cys Ser  Pro Gly Trp Cys Ser  Ala Phe Tyr Glu Ala  Asp Cys Phe 
    1025                 1030                 1035             


Gly Ala  Asp Val His Asn Tyr  Val Lys Asp Leu Gly  Arg Gln Gln 
    1040                 1045                 1050             


Ala Asp  Gly Ala Leu Pro Asp  Ala Gln Ser Pro Glu  Leu Glu Gln 
    1055                 1060                 1065             


Gln Leu  Met Met Glu Lys Arg  Asn Tyr Arg Lys Thr  Leu Lys Phe 
    1070                 1075                 1080             


Tyr Gln  Lys Leu Leu Gln Lys  Glu Lys Arg Asn Lys  Gly Ser Asp 
    1085                 1090                 1095             


Val Lys  Thr Met Leu Ser Lys  Leu Lys Gly Gln Leu  Glu Glu Met 
    1100                 1105                 1110             


Lys Ser  Arg Val Gln Phe Leu  Ser Leu Val Lys Lys  Tyr Leu Gln 
    1115                 1120                 1125             


Ala Ser  Gly Leu Arg Ala Pro  Leu Cys Pro Val Arg  Gln 
    1130                 1135                 1140     


<210>  7595
<211>  391
<212>  PRT
<213>  Homo Sapiens

<400>  7595

Met Lys Leu Ile Thr Ile Leu Phe Leu Cys Ser Arg Leu Leu Leu Ser 
1               5                   10                  15      


Leu Thr Gln Glu Ser Gln Ser Glu Glu Ile Asp Cys Asn Asp Lys Asp 
            20                  25                  30          


Leu Phe Lys Ala Val Asp Ala Ala Leu Lys Lys Tyr Asn Ser Gln Asn 
        35                  40                  45              


Gln Ser Asn Asn Gln Phe Val Leu Tyr Arg Ile Thr Glu Ala Thr Lys 
    50                  55                  60                  


Thr Val Gly Ser Asp Thr Phe Tyr Ser Phe Lys Tyr Glu Ile Lys Glu 
65                  70                  75                  80  


Gly Asp Cys Pro Val Gln Ser Gly Lys Thr Trp Gln Asp Cys Glu Tyr 
                85                  90                  95      


Lys Asp Ala Ala Lys Ala Ala Thr Gly Glu Cys Thr Ala Thr Val Gly 
            100                 105                 110         


Lys Arg Ser Ser Thr Lys Phe Ser Val Ala Thr Gln Thr Cys Gln Ile 
        115                 120                 125             


Thr Pro Ala Glu Gly Pro Val Val Thr Ala Gln Tyr Asp Cys Leu Gly 
    130                 135                 140                 


Cys Val His Pro Ile Ser Thr Gln Ser Pro Asp Leu Glu Pro Ile Leu 
145                 150                 155                 160 


Arg His Gly Ile Gln Tyr Phe Asn Asn Asn Thr Gln His Ser Ser Leu 
                165                 170                 175     


Phe Met Leu Asn Glu Val Lys Arg Ala Gln Arg Gln Asp Thr Gly Glu 
            180                 185                 190         


Cys Thr Asp Asn Ala Tyr Ile Asp Ile Gln Leu Arg Ile Ala Ser Phe 
        195                 200                 205             


Ser Gln Asn Cys Asp Ile Tyr Pro Gly Lys Asp Phe Val Gln Pro Pro 
    210                 215                 220                 


Thr Lys Ile Cys Val Gly Cys Pro Arg Asp Ile Pro Thr Asn Ser Pro 
225                 230                 235                 240 


Glu Leu Glu Glu Thr Leu Thr His Thr Ile Thr Lys Leu Asn Ala Glu 
                245                 250                 255     


Asn Asn Ala Thr Phe Tyr Phe Lys Ile Asp Asn Val Lys Lys Ala Arg 
            260                 265                 270         


Val Gln Val Val Ala Gly Lys Lys Tyr Phe Ile Asp Phe Val Ala Arg 
        275                 280                 285             


Glu Thr Thr Cys Ser Lys Glu Ser Asn Glu Glu Leu Thr Glu Ser Cys 
    290                 295                 300                 


Glu Thr Lys Lys Leu Gly Gln Ser Leu Asp Cys Asn Ala Glu Val Tyr 
305                 310                 315                 320 


Val Val Pro Trp Glu Lys Lys Ile Tyr Pro Thr Val Asn Cys Gln Pro 
                325                 330                 335     


Leu Gly Met Ile Ser Leu Met Lys Arg Pro Pro Gly Phe Ser Pro Phe 
            340                 345                 350         


Arg Ser Ser Arg Ile Gly Glu Ile Lys Glu Glu Thr Thr Ser His Leu 
        355                 360                 365             


Arg Ser Cys Glu Tyr Lys Gly Arg Pro Pro Lys Ala Gly Ala Glu Pro 
    370                 375                 380                 


Ala Ser Glu Arg Glu Val Ser 
385                 390     


<210>  7596
<211>  427
<212>  PRT
<213>  Homo Sapiens

<400>  7596

Met Lys Leu Ile Thr Ile Leu Phe Leu Cys Ser Arg Leu Leu Leu Ser 
1               5                   10                  15      


Leu Thr Gln Glu Ser Gln Ser Glu Glu Ile Asp Cys Asn Asp Lys Asp 
            20                  25                  30          


Leu Phe Lys Ala Val Asp Ala Ala Leu Lys Lys Tyr Asn Ser Gln Asn 
        35                  40                  45              


Gln Ser Asn Asn Gln Phe Val Leu Tyr Arg Ile Thr Glu Ala Thr Lys 
    50                  55                  60                  


Thr Val Gly Ser Asp Thr Phe Tyr Ser Phe Lys Tyr Glu Ile Lys Glu 
65                  70                  75                  80  


Gly Asp Cys Pro Val Gln Ser Gly Lys Thr Trp Gln Asp Cys Glu Tyr 
                85                  90                  95      


Lys Asp Ala Ala Lys Ala Ala Thr Gly Glu Cys Thr Ala Thr Val Gly 
            100                 105                 110         


Lys Arg Ser Ser Thr Lys Phe Ser Val Ala Thr Gln Thr Cys Gln Ile 
        115                 120                 125             


Thr Pro Ala Glu Gly Pro Val Val Thr Ala Gln Tyr Asp Cys Leu Gly 
    130                 135                 140                 


Cys Val His Pro Ile Ser Thr Gln Ser Pro Asp Leu Glu Pro Ile Leu 
145                 150                 155                 160 


Arg His Gly Ile Gln Tyr Phe Asn Asn Asn Thr Gln His Ser Ser Leu 
                165                 170                 175     


Phe Met Leu Asn Glu Val Lys Arg Ala Gln Arg Gln Val Val Ala Gly 
            180                 185                 190         


Leu Asn Phe Arg Ile Thr Tyr Ser Ile Val Gln Thr Asn Cys Ser Lys 
        195                 200                 205             


Glu Asn Phe Leu Phe Leu Thr Pro Asp Cys Lys Ser Leu Trp Asn Gly 
    210                 215                 220                 


Asp Thr Gly Glu Cys Thr Asp Asn Ala Tyr Ile Asp Ile Gln Leu Arg 
225                 230                 235                 240 


Ile Ala Ser Phe Ser Gln Asn Cys Asp Ile Tyr Pro Gly Lys Asp Phe 
                245                 250                 255     


Val Gln Pro Pro Thr Lys Ile Cys Val Gly Cys Pro Arg Asp Ile Pro 
            260                 265                 270         


Thr Asn Ser Pro Glu Leu Glu Glu Thr Leu Thr His Thr Ile Thr Lys 
        275                 280                 285             


Leu Asn Ala Glu Asn Asn Ala Thr Phe Tyr Phe Lys Ile Asp Asn Val 
    290                 295                 300                 


Lys Lys Ala Arg Val Gln Val Val Ala Gly Lys Lys Tyr Phe Ile Asp 
305                 310                 315                 320 


Phe Val Ala Arg Glu Thr Thr Cys Ser Lys Glu Ser Asn Glu Glu Leu 
                325                 330                 335     


Thr Glu Ser Cys Glu Thr Lys Lys Leu Gly Gln Ser Leu Asp Cys Asn 
            340                 345                 350         


Ala Glu Val Tyr Val Val Pro Trp Glu Lys Lys Ile Tyr Pro Thr Val 
        355                 360                 365             


Asn Cys Gln Pro Leu Gly Met Ile Ser Leu Met Lys Arg Pro Pro Gly 
    370                 375                 380                 


Phe Ser Pro Phe Arg Ser Ser Arg Ile Gly Glu Ile Lys Glu Glu Thr 
385                 390                 395                 400 


Thr Ser His Leu Arg Ser Cys Glu Tyr Lys Gly Arg Pro Pro Lys Ala 
                405                 410                 415     


Gly Ala Glu Pro Ala Ser Glu Arg Glu Val Ser 
            420                 425         


<210>  7597
<211>  644
<212>  PRT
<213>  Homo Sapiens

<400>  7597

Met Lys Leu Ile Thr Ile Leu Phe Leu Cys Ser Arg Leu Leu Leu Ser 
1               5                   10                  15      


Leu Thr Gln Glu Ser Gln Ser Glu Glu Ile Asp Cys Asn Asp Lys Asp 
            20                  25                  30          


Leu Phe Lys Ala Val Asp Ala Ala Leu Lys Lys Tyr Asn Ser Gln Asn 
        35                  40                  45              


Gln Ser Asn Asn Gln Phe Val Leu Tyr Arg Ile Thr Glu Ala Thr Lys 
    50                  55                  60                  


Thr Val Gly Ser Asp Thr Phe Tyr Ser Phe Lys Tyr Glu Ile Lys Glu 
65                  70                  75                  80  


Gly Asp Cys Pro Val Gln Ser Gly Lys Thr Trp Gln Asp Cys Glu Tyr 
                85                  90                  95      


Lys Asp Ala Ala Lys Ala Ala Thr Gly Glu Cys Thr Ala Thr Val Gly 
            100                 105                 110         


Lys Arg Ser Ser Thr Lys Phe Ser Val Ala Thr Gln Thr Cys Gln Ile 
        115                 120                 125             


Thr Pro Ala Glu Gly Pro Val Val Thr Ala Gln Tyr Asp Cys Leu Gly 
    130                 135                 140                 


Cys Val His Pro Ile Ser Thr Gln Ser Pro Asp Leu Glu Pro Ile Leu 
145                 150                 155                 160 


Arg His Gly Ile Gln Tyr Phe Asn Asn Asn Thr Gln His Ser Ser Leu 
                165                 170                 175     


Phe Met Leu Asn Glu Val Lys Arg Ala Gln Arg Gln Val Val Ala Gly 
            180                 185                 190         


Leu Asn Phe Arg Ile Thr Tyr Ser Ile Val Gln Thr Asn Cys Ser Lys 
        195                 200                 205             


Glu Asn Phe Leu Phe Leu Thr Pro Asp Cys Lys Ser Leu Trp Asn Gly 
    210                 215                 220                 


Asp Thr Gly Glu Cys Thr Asp Asn Ala Tyr Ile Asp Ile Gln Leu Arg 
225                 230                 235                 240 


Ile Ala Ser Phe Ser Gln Asn Cys Asp Ile Tyr Pro Gly Lys Asp Phe 
                245                 250                 255     


Val Gln Pro Pro Thr Lys Ile Cys Val Gly Cys Pro Arg Asp Ile Pro 
            260                 265                 270         


Thr Asn Ser Pro Glu Leu Glu Glu Thr Leu Thr His Thr Ile Thr Lys 
        275                 280                 285             


Leu Asn Ala Glu Asn Asn Ala Thr Phe Tyr Phe Lys Ile Asp Asn Val 
    290                 295                 300                 


Lys Lys Ala Arg Val Gln Val Val Ala Gly Lys Lys Tyr Phe Ile Asp 
305                 310                 315                 320 


Phe Val Ala Arg Glu Thr Thr Cys Ser Lys Glu Ser Asn Glu Glu Leu 
                325                 330                 335     


Thr Glu Ser Cys Glu Thr Lys Lys Leu Gly Gln Ser Leu Asp Cys Asn 
            340                 345                 350         


Ala Glu Val Tyr Val Val Pro Trp Glu Lys Lys Ile Tyr Pro Thr Val 
        355                 360                 365             


Asn Cys Gln Pro Leu Gly Met Ile Ser Leu Met Lys Arg Pro Pro Gly 
    370                 375                 380                 


Phe Ser Pro Phe Arg Ser Ser Arg Ile Gly Glu Ile Lys Glu Glu Thr 
385                 390                 395                 400 


Thr Val Ser Pro Pro His Thr Ser Met Ala Pro Ala Gln Asp Glu Glu 
                405                 410                 415     


Arg Asp Ser Gly Lys Glu Gln Gly His Thr Arg Arg His Asp Trp Gly 
            420                 425                 430         


His Glu Lys Gln Arg Lys His Asn Leu Gly His Gly His Lys His Glu 
        435                 440                 445             


Arg Asp Gln Gly His Gly His Gln Arg Gly His Gly Leu Gly His Gly 
    450                 455                 460                 


His Glu Gln Gln His Gly Leu Gly His Gly His Lys Phe Lys Leu Asp 
465                 470                 475                 480 


Asp Asp Leu Glu His Gln Gly Gly His Val Leu Asp His Gly His Lys 
                485                 490                 495     


His Lys His Gly His Gly His Gly Lys His Lys Asn Lys Gly Lys Lys 
            500                 505                 510         


Asn Gly Lys His Asn Gly Trp Lys Thr Glu His Leu Ala Ser Ser Ser 
        515                 520                 525             


Glu Asp Ser Thr Thr Pro Ser Ala Gln Thr Gln Glu Lys Thr Glu Gly 
    530                 535                 540                 


Pro Thr Pro Ile Pro Ser Leu Ala Lys Pro Gly Val Thr Val Thr Phe 
545                 550                 555                 560 


Ser Asp Phe Gln Asp Ser Asp Leu Ile Ala Thr Met Met Pro Pro Ile 
                565                 570                 575     


Ser Pro Ala Pro Ile Gln Ser Asp Asp Asp Trp Ile Pro Asp Ile Gln 
            580                 585                 590         


Ile Asp Pro Asn Gly Leu Ser Phe Asn Pro Ile Ser Asp Phe Pro Asp 
        595                 600                 605             


Thr Thr Ser Pro Lys Cys Pro Gly Arg Pro Trp Lys Ser Val Ser Glu 
    610                 615                 620                 


Ile Asn Pro Thr Thr Gln Met Lys Glu Ser Tyr Tyr Phe Asp Leu Thr 
625                 630                 635                 640 


Asp Gly Leu Ser 
                


<210>  7598
<211>  427
<212>  PRT
<213>  Homo Sapiens

<400>  7598

Met Lys Leu Ile Thr Ile Leu Phe Leu Cys Ser Arg Leu Leu Leu Ser 
1               5                   10                  15      


Leu Thr Gln Glu Ser Gln Ser Glu Glu Ile Asp Cys Asn Asp Lys Asp 
            20                  25                  30          


Leu Phe Lys Ala Val Asp Ala Ala Leu Lys Lys Tyr Asn Ser Gln Asn 
        35                  40                  45              


Gln Ser Asn Asn Gln Phe Val Leu Tyr Arg Ile Thr Glu Ala Thr Lys 
    50                  55                  60                  


Thr Val Gly Ser Asp Thr Phe Tyr Ser Phe Lys Tyr Glu Ile Lys Glu 
65                  70                  75                  80  


Gly Asp Cys Pro Val Gln Ser Gly Lys Thr Trp Gln Asp Cys Glu Tyr 
                85                  90                  95      


Lys Asp Ala Ala Lys Ala Ala Thr Gly Glu Cys Thr Ala Thr Val Gly 
            100                 105                 110         


Lys Arg Ser Ser Thr Lys Phe Ser Val Ala Thr Gln Thr Cys Gln Ile 
        115                 120                 125             


Thr Pro Ala Glu Gly Pro Val Val Thr Ala Gln Tyr Asp Cys Leu Gly 
    130                 135                 140                 


Cys Val His Pro Ile Ser Thr Gln Ser Pro Asp Leu Glu Pro Ile Leu 
145                 150                 155                 160 


Arg His Gly Ile Gln Tyr Phe Asn Asn Asn Thr Gln His Ser Ser Leu 
                165                 170                 175     


Phe Met Leu Asn Glu Val Lys Arg Ala Gln Arg Gln Val Val Ala Gly 
            180                 185                 190         


Leu Asn Phe Arg Ile Thr Tyr Ser Ile Val Gln Thr Asn Cys Ser Lys 
        195                 200                 205             


Glu Asn Phe Leu Phe Leu Thr Pro Asp Cys Lys Ser Leu Trp Asn Gly 
    210                 215                 220                 


Asp Thr Gly Glu Cys Thr Asp Asn Ala Tyr Ile Asp Ile Gln Leu Arg 
225                 230                 235                 240 


Ile Ala Ser Phe Ser Gln Asn Cys Asp Ile Tyr Pro Gly Lys Asp Phe 
                245                 250                 255     


Val Gln Pro Pro Thr Lys Ile Cys Val Gly Cys Pro Arg Asp Ile Pro 
            260                 265                 270         


Thr Asn Ser Pro Glu Leu Glu Glu Thr Leu Thr His Thr Ile Thr Lys 
        275                 280                 285             


Leu Asn Ala Glu Asn Asn Ala Thr Phe Tyr Phe Lys Ile Asp Asn Val 
    290                 295                 300                 


Lys Lys Ala Arg Val Gln Val Val Ala Gly Lys Lys Tyr Phe Ile Asp 
305                 310                 315                 320 


Phe Val Ala Arg Glu Thr Thr Cys Ser Lys Glu Ser Asn Glu Glu Leu 
                325                 330                 335     


Thr Glu Ser Cys Glu Thr Lys Lys Leu Gly Gln Ser Leu Asp Cys Asn 
            340                 345                 350         


Ala Glu Val Tyr Val Val Pro Trp Glu Lys Lys Ile Tyr Pro Thr Val 
        355                 360                 365             


Asn Cys Gln Pro Leu Gly Met Ile Ser Leu Met Lys Arg Pro Pro Gly 
    370                 375                 380                 


Phe Ser Pro Phe Arg Ser Ser Arg Ile Gly Glu Ile Lys Glu Glu Thr 
385                 390                 395                 400 


Thr Ser His Leu Arg Ser Cys Glu Tyr Lys Gly Arg Pro Pro Lys Ala 
                405                 410                 415     


Gly Ala Glu Pro Ala Ser Glu Arg Glu Val Ser 
            420                 425         


<210>  7599
<211>  644
<212>  PRT
<213>  Homo Sapiens

<400>  7599

Met Lys Leu Ile Thr Ile Leu Phe Leu Cys Ser Arg Leu Leu Leu Ser 
1               5                   10                  15      


Leu Thr Gln Glu Ser Gln Ser Glu Glu Ile Asp Cys Asn Asp Lys Asp 
            20                  25                  30          


Leu Phe Lys Ala Val Asp Ala Ala Leu Lys Lys Tyr Asn Ser Gln Asn 
        35                  40                  45              


Gln Ser Asn Asn Gln Phe Val Leu Tyr Arg Ile Thr Glu Ala Thr Lys 
    50                  55                  60                  


Thr Val Gly Ser Asp Thr Phe Tyr Ser Phe Lys Tyr Glu Ile Lys Glu 
65                  70                  75                  80  


Gly Asp Cys Pro Val Gln Ser Gly Lys Thr Trp Gln Asp Cys Glu Tyr 
                85                  90                  95      


Lys Asp Ala Ala Lys Ala Ala Thr Gly Glu Cys Thr Ala Thr Val Gly 
            100                 105                 110         


Lys Arg Ser Ser Thr Lys Phe Ser Val Ala Thr Gln Thr Cys Gln Ile 
        115                 120                 125             


Thr Pro Ala Glu Gly Pro Val Val Thr Ala Gln Tyr Asp Cys Leu Gly 
    130                 135                 140                 


Cys Val His Pro Ile Ser Thr Gln Ser Pro Asp Leu Glu Pro Ile Leu 
145                 150                 155                 160 


Arg His Gly Ile Gln Tyr Phe Asn Asn Asn Thr Gln His Ser Ser Leu 
                165                 170                 175     


Phe Met Leu Asn Glu Val Lys Arg Ala Gln Arg Gln Val Val Ala Gly 
            180                 185                 190         


Leu Asn Phe Arg Ile Thr Tyr Ser Ile Val Gln Thr Asn Cys Ser Lys 
        195                 200                 205             


Glu Asn Phe Leu Phe Leu Thr Pro Asp Cys Lys Ser Leu Trp Asn Gly 
    210                 215                 220                 


Asp Thr Gly Glu Cys Thr Asp Asn Ala Tyr Ile Asp Ile Gln Leu Arg 
225                 230                 235                 240 


Ile Ala Ser Phe Ser Gln Asn Cys Asp Ile Tyr Pro Gly Lys Asp Phe 
                245                 250                 255     


Val Gln Pro Pro Thr Lys Ile Cys Val Gly Cys Pro Arg Asp Ile Pro 
            260                 265                 270         


Thr Asn Ser Pro Glu Leu Glu Glu Thr Leu Thr His Thr Ile Thr Lys 
        275                 280                 285             


Leu Asn Ala Glu Asn Asn Ala Thr Phe Tyr Phe Lys Ile Asp Asn Val 
    290                 295                 300                 


Lys Lys Ala Arg Val Gln Val Val Ala Gly Lys Lys Tyr Phe Ile Asp 
305                 310                 315                 320 


Phe Val Ala Arg Glu Thr Thr Cys Ser Lys Glu Ser Asn Glu Glu Leu 
                325                 330                 335     


Thr Glu Ser Cys Glu Thr Lys Lys Leu Gly Gln Ser Leu Asp Cys Asn 
            340                 345                 350         


Ala Glu Val Tyr Val Val Pro Trp Glu Lys Lys Ile Tyr Pro Thr Val 
        355                 360                 365             


Asn Cys Gln Pro Leu Gly Met Ile Ser Leu Met Lys Arg Pro Pro Gly 
    370                 375                 380                 


Phe Ser Pro Phe Arg Ser Ser Arg Ile Gly Glu Ile Lys Glu Glu Thr 
385                 390                 395                 400 


Thr Val Ser Pro Pro His Thr Ser Met Ala Pro Ala Gln Asp Glu Glu 
                405                 410                 415     


Arg Asp Ser Gly Lys Glu Gln Gly His Thr Arg Arg His Asp Trp Gly 
            420                 425                 430         


His Glu Lys Gln Arg Lys His Asn Leu Gly His Gly His Lys His Glu 
        435                 440                 445             


Arg Asp Gln Gly His Gly His Gln Arg Gly His Gly Leu Gly His Gly 
    450                 455                 460                 


His Glu Gln Gln His Gly Leu Gly His Gly His Lys Phe Lys Leu Asp 
465                 470                 475                 480 


Asp Asp Leu Glu His Gln Gly Gly His Val Leu Asp His Gly His Lys 
                485                 490                 495     


His Lys His Gly His Gly His Gly Lys His Lys Asn Lys Gly Lys Lys 
            500                 505                 510         


Asn Gly Lys His Asn Gly Trp Lys Thr Glu His Leu Ala Ser Ser Ser 
        515                 520                 525             


Glu Asp Ser Thr Thr Pro Ser Ala Gln Thr Gln Glu Lys Thr Glu Gly 
    530                 535                 540                 


Pro Thr Pro Ile Pro Ser Leu Ala Lys Pro Gly Val Thr Val Thr Phe 
545                 550                 555                 560 


Ser Asp Phe Gln Asp Ser Asp Leu Ile Ala Thr Met Met Pro Pro Ile 
                565                 570                 575     


Ser Pro Ala Pro Ile Gln Ser Asp Asp Asp Trp Ile Pro Asp Ile Gln 
            580                 585                 590         


Ile Asp Pro Asn Gly Leu Ser Phe Asn Pro Ile Ser Asp Phe Pro Asp 
        595                 600                 605             


Thr Thr Ser Pro Lys Cys Pro Gly Arg Pro Trp Lys Ser Val Ser Glu 
    610                 615                 620                 


Ile Asn Pro Thr Thr Gln Met Lys Glu Ser Tyr Tyr Phe Asp Leu Thr 
625                 630                 635                 640 


Asp Gly Leu Ser 
                


<210>  7600
<211>  458
<212>  PRT
<213>  Homo Sapiens

<400>  7600

Met Leu Phe Gln Glu Ala Thr Ala Phe Glu Asn Met Thr Lys Asp Trp 
1               5                   10                  15      


Asn Tyr Leu Glu Gly Ser Gln Lys Asp Cys Tyr Arg Asp Thr Met Leu 
            20                  25                  30          


Asp Ser Tyr Glu Asn Thr Val Pro Gln Gly Ser Phe Leu Gln Leu Ser 
        35                  40                  45              


Met Met Pro Gln Arg Ala Gly Asn Asp Pro Pro Gly Val Ser Asn Ala 
    50                  55                  60                  


Ser Glu Met Glu Met Glu Ile Ser Asn Met Arg Glu Lys Phe Leu Met 
65                  70                  75                  80  


Ser Val Thr Lys Leu Val Glu Ser Lys Ser Tyr Asn Ser Lys Val Phe 
                85                  90                  95      


Ser Lys Glu Lys Tyr Phe Gln Thr Ile Lys Glu Val Lys Glu Ala Lys 
            100                 105                 110         


Glu Lys Gly Lys Lys Ser Ser Arg Asp Tyr Arg Arg Ala Ala Lys Tyr 
        115                 120                 125             


Asp Val Ile Ser Val Gln Gly Thr Glu Lys Leu Ile Glu Ala Thr His 
    130                 135                 140                 


Gly Glu Arg Asp Arg Ile Arg Tyr Tyr Val His Lys Glu Glu Leu Phe 
145                 150                 155                 160 


Asp Ile Leu His Asp Thr His Leu Ser Ile Gly His Gly Gly Arg Thr 
                165                 170                 175     


Arg Met Leu Lys Glu Leu Gln Gly Lys Tyr Gly Asn Val Thr Lys Glu 
            180                 185                 190         


Val Ile Val Leu Tyr Leu Thr Leu Cys Lys Gln Cys His Gln Lys Asn 
        195                 200                 205             


Pro Val Pro Lys Arg Gly Leu Ala Pro Lys Pro Met Thr Phe Lys Asp 
    210                 215                 220                 


Ile Asp Ser Thr Cys Gln Val Glu Ile Leu Asp Met Gln Ser Ser Ala 
225                 230                 235                 240 


Asp Gly Glu Phe Lys Phe Ile Leu Tyr Tyr Gln Asp His Ser Thr Lys 
                245                 250                 255     


Phe Ile Ile Leu Arg Pro Leu Arg Thr Lys Gln Ala His Glu Val Val 
            260                 265                 270         


Ser Val Leu Leu Asp Ile Phe Thr Ile Leu Gly Thr Pro Ser Val Leu 
        275                 280                 285             


Asp Ser Asp Ser Gly Val Glu Phe Thr Asn Gln Val Val His Glu Leu 
    290                 295                 300                 


Asn Glu Leu Trp Pro Asp Leu Lys Ile Val Ser Gly Lys Tyr His Pro 
305                 310                 315                 320 


Gly Gln Ser Gln Gly Ser Leu Glu Gly Ala Ser Arg Asp Val Lys Asn 
                325                 330                 335     


Met Ile Ser Thr Trp Met Gln Ser Asn His Ser Cys His Trp Ala Lys 
            340                 345                 350         


Gly Leu Arg Phe Met Gln Met Val Arg Asn Gln Ala Phe Asp Val Ser 
        355                 360                 365             


Leu Gln Gln Ser Pro Phe Glu Ala Met Phe Gly Tyr Lys Ala Lys Phe 
    370                 375                 380                 


Gly Leu Tyr Ser Ser Asn Leu Pro Arg Glu Thr Val Ala Thr Leu Gln 
385                 390                 395                 400 


Thr Glu Glu Glu Leu Glu Ile Ala Glu Glu Gln Leu Glu Asn Ser Leu 
                405                 410                 415     


Trp Ile Arg Gln Glu Glu Arg Ala Glu Ile Gly Ala Asp Arg Ser Asp 
            420                 425                 430         


Met Asp Asp Asp Met Asp Pro Thr Pro Glu Ala Ser Glu Pro Ser Thr 
        435                 440                 445             


Ser Gln Gly Thr Ser Gly Leu Leu Cys Trp 
    450                 455             


<210>  7601
<211>  410
<212>  PRT
<213>  Homo Sapiens

<400>  7601

Met Met Pro Gln Arg Ala Gly Asn Asp Pro Pro Gly Val Ser Asn Ala 
1               5                   10                  15      


Ser Glu Met Glu Met Glu Ile Ser Asn Met Arg Glu Lys Phe Leu Met 
            20                  25                  30          


Ser Val Thr Lys Leu Val Glu Ser Lys Ser Tyr Asn Ser Lys Val Phe 
        35                  40                  45              


Ser Lys Glu Lys Tyr Phe Gln Thr Ile Lys Glu Val Lys Glu Ala Lys 
    50                  55                  60                  


Glu Lys Gly Lys Lys Ser Ser Arg Asp Tyr Arg Arg Ala Ala Lys Tyr 
65                  70                  75                  80  


Asp Val Ile Ser Val Gln Gly Thr Glu Lys Leu Ile Glu Ala Thr His 
                85                  90                  95      


Gly Glu Arg Asp Arg Ile Arg Tyr Tyr Val His Lys Glu Glu Leu Phe 
            100                 105                 110         


Asp Ile Leu His Asp Thr His Leu Ser Ile Gly His Gly Gly Arg Thr 
        115                 120                 125             


Arg Met Leu Lys Glu Leu Gln Gly Lys Tyr Gly Asn Val Thr Lys Glu 
    130                 135                 140                 


Val Ile Val Leu Tyr Leu Thr Leu Cys Lys Gln Cys His Gln Lys Asn 
145                 150                 155                 160 


Pro Val Pro Lys Arg Gly Leu Ala Pro Lys Pro Met Thr Phe Lys Asp 
                165                 170                 175     


Ile Asp Ser Thr Cys Gln Val Glu Ile Leu Asp Met Gln Ser Ser Ala 
            180                 185                 190         


Asp Gly Glu Phe Lys Phe Ile Leu Tyr Tyr Gln Asp His Ser Thr Lys 
        195                 200                 205             


Phe Ile Ile Leu Arg Pro Leu Arg Thr Lys Gln Ala His Glu Val Val 
    210                 215                 220                 


Ser Val Leu Leu Asp Ile Phe Thr Ile Leu Gly Thr Pro Ser Val Leu 
225                 230                 235                 240 


Asp Ser Asp Ser Gly Val Glu Phe Thr Asn Gln Val Val His Glu Leu 
                245                 250                 255     


Asn Glu Leu Trp Pro Asp Leu Lys Ile Val Ser Gly Lys Tyr His Pro 
            260                 265                 270         


Gly Gln Ser Gln Gly Ser Leu Glu Gly Ala Ser Arg Asp Val Lys Asn 
        275                 280                 285             


Met Ile Ser Thr Trp Met Gln Ser Asn His Ser Cys His Trp Ala Lys 
    290                 295                 300                 


Gly Leu Arg Phe Met Gln Met Val Arg Asn Gln Ala Phe Asp Val Ser 
305                 310                 315                 320 


Leu Gln Gln Ser Pro Phe Glu Ala Met Phe Gly Tyr Lys Ala Lys Phe 
                325                 330                 335     


Gly Leu Tyr Ser Ser Asn Leu Pro Arg Glu Thr Val Ala Thr Leu Gln 
            340                 345                 350         


Thr Glu Glu Glu Leu Glu Ile Ala Glu Glu Gln Leu Glu Asn Ser Leu 
        355                 360                 365             


Trp Ile Arg Gln Glu Glu Arg Ala Glu Ile Gly Ala Asp Arg Ser Asp 
    370                 375                 380                 


Met Asp Asp Asp Met Asp Pro Thr Pro Glu Ala Ser Glu Pro Ser Thr 
385                 390                 395                 400 


Ser Gln Gly Thr Ser Gly Leu Leu Cys Trp 
                405                 410 


<210>  7602
<211>  492
<212>  PRT
<213>  Homo Sapiens

<400>  7602

Met Pro Ser Phe Leu Val Pro Ser Leu Val Ser Ser Pro Val Leu Leu 
1               5                   10                  15      


Lys Leu Leu Phe Ser Pro Gly Pro Lys Thr Ile Trp Ser Leu Trp Gln 
            20                  25                  30          


Gln Pro Met Leu Phe Gln Glu Ala Thr Ala Phe Glu Asn Met Thr Lys 
        35                  40                  45              


Asp Trp Asn Tyr Leu Glu Gly Ser Gln Lys Asp Cys Tyr Arg Asp Thr 
    50                  55                  60                  


Met Leu Asp Ser Tyr Glu Asn Thr Val Pro Gln Gly Ser Phe Leu Gln 
65                  70                  75                  80  


Leu Ser Met Met Pro Gln Arg Ala Gly Asn Asp Pro Pro Gly Val Ser 
                85                  90                  95      


Asn Ala Ser Glu Met Glu Met Glu Ile Ser Asn Met Arg Glu Lys Phe 
            100                 105                 110         


Leu Met Ser Val Thr Lys Leu Val Glu Ser Lys Ser Tyr Asn Ser Lys 
        115                 120                 125             


Val Phe Ser Lys Glu Lys Tyr Phe Gln Thr Ile Lys Glu Val Lys Glu 
    130                 135                 140                 


Ala Lys Glu Lys Gly Lys Lys Ser Ser Arg Asp Tyr Arg Arg Ala Ala 
145                 150                 155                 160 


Lys Tyr Asp Val Ile Ser Val Gln Gly Thr Glu Lys Leu Ile Glu Ala 
                165                 170                 175     


Thr His Gly Glu Arg Asp Arg Ile Arg Tyr Tyr Val His Lys Glu Glu 
            180                 185                 190         


Leu Phe Asp Ile Leu His Asp Thr His Leu Ser Ile Gly His Gly Gly 
        195                 200                 205             


Arg Thr Arg Met Leu Lys Glu Leu Gln Gly Lys Tyr Gly Asn Val Thr 
    210                 215                 220                 


Lys Glu Val Ile Val Leu Tyr Leu Thr Leu Cys Lys Gln Cys His Gln 
225                 230                 235                 240 


Lys Asn Pro Val Pro Lys Arg Gly Leu Ala Pro Lys Pro Met Thr Phe 
                245                 250                 255     


Lys Asp Ile Asp Ser Thr Cys Gln Val Glu Ile Leu Asp Met Gln Ser 
            260                 265                 270         


Ser Ala Asp Gly Glu Phe Lys Phe Ile Leu Tyr Tyr Gln Asp His Ser 
        275                 280                 285             


Thr Lys Phe Ile Ile Leu Arg Pro Leu Arg Thr Lys Gln Ala His Glu 
    290                 295                 300                 


Val Val Ser Val Leu Leu Asp Ile Phe Thr Ile Leu Gly Thr Pro Ser 
305                 310                 315                 320 


Val Leu Asp Ser Asp Ser Gly Val Glu Phe Thr Asn Gln Val Val His 
                325                 330                 335     


Glu Leu Asn Glu Leu Trp Pro Asp Leu Lys Ile Val Ser Gly Lys Tyr 
            340                 345                 350         


His Pro Gly Gln Ser Gln Gly Ser Leu Glu Gly Ala Ser Arg Asp Val 
        355                 360                 365             


Lys Asn Met Ile Ser Thr Trp Met Gln Ser Asn His Ser Cys His Trp 
    370                 375                 380                 


Ala Lys Gly Leu Arg Phe Met Gln Met Val Arg Asn Gln Ala Phe Asp 
385                 390                 395                 400 


Val Ser Leu Gln Gln Ser Pro Phe Glu Ala Met Phe Gly Tyr Lys Ala 
                405                 410                 415     


Lys Phe Gly Leu Tyr Ser Ser Asn Leu Pro Arg Glu Thr Val Ala Thr 
            420                 425                 430         


Leu Gln Thr Glu Glu Glu Leu Glu Ile Ala Glu Glu Gln Leu Glu Asn 
        435                 440                 445             


Ser Leu Trp Ile Arg Gln Glu Glu Arg Ala Glu Ile Gly Ala Asp Arg 
    450                 455                 460                 


Ser Asp Met Asp Asp Asp Met Asp Pro Thr Pro Glu Ala Ser Glu Pro 
465                 470                 475                 480 


Ser Thr Ser Gln Gly Thr Ser Gly Leu Leu Cys Trp 
                485                 490         


<210>  7603
<211>  492
<212>  PRT
<213>  Homo Sapiens

<400>  7603

Met Pro Ser Phe Leu Val Pro Ser Leu Val Ser Ser Pro Val Leu Leu 
1               5                   10                  15      


Lys Leu Leu Phe Ser Pro Gly Pro Lys Thr Ile Trp Ser Leu Trp Gln 
            20                  25                  30          


Gln Pro Met Leu Phe Gln Glu Ala Thr Ala Phe Glu Asn Met Thr Lys 
        35                  40                  45              


Asp Trp Asn Tyr Leu Glu Gly Ser Gln Lys Asp Cys Tyr Arg Asp Thr 
    50                  55                  60                  


Met Leu Asp Ser Tyr Glu Asn Thr Val Pro Gln Gly Ser Phe Leu Gln 
65                  70                  75                  80  


Leu Ser Met Met Pro Gln Arg Ala Gly Asn Asp Pro Pro Gly Val Ser 
                85                  90                  95      


Asn Ala Ser Glu Met Glu Met Glu Ile Ser Asn Met Arg Glu Lys Phe 
            100                 105                 110         


Leu Met Ser Val Thr Lys Leu Val Glu Ser Lys Ser Tyr Asn Ser Lys 
        115                 120                 125             


Val Phe Ser Lys Glu Lys Tyr Phe Gln Thr Ile Lys Glu Val Lys Glu 
    130                 135                 140                 


Ala Lys Glu Lys Gly Lys Lys Ser Ser Arg Asp Tyr Arg Arg Ala Ala 
145                 150                 155                 160 


Lys Tyr Asp Val Ile Ser Val Gln Gly Thr Glu Lys Leu Ile Glu Ala 
                165                 170                 175     


Thr His Gly Glu Arg Asp Arg Ile Arg Tyr Tyr Val His Lys Glu Glu 
            180                 185                 190         


Leu Phe Asp Ile Leu His Asp Thr His Leu Ser Ile Gly His Gly Gly 
        195                 200                 205             


Arg Thr Arg Met Leu Lys Glu Leu Gln Gly Lys Tyr Gly Asn Val Thr 
    210                 215                 220                 


Lys Glu Val Ile Val Leu Tyr Leu Thr Leu Cys Lys Gln Cys His Gln 
225                 230                 235                 240 


Lys Asn Pro Val Pro Lys Arg Gly Leu Ala Pro Lys Pro Met Thr Phe 
                245                 250                 255     


Lys Asp Ile Asp Ser Thr Cys Gln Val Glu Ile Leu Asp Met Gln Ser 
            260                 265                 270         


Ser Ala Asp Gly Glu Phe Lys Phe Ile Leu Tyr Tyr Gln Asp His Ser 
        275                 280                 285             


Thr Lys Phe Ile Ile Leu Arg Pro Leu Arg Thr Lys Gln Ala His Glu 
    290                 295                 300                 


Val Val Ser Val Leu Leu Asp Ile Phe Thr Ile Leu Gly Thr Pro Ser 
305                 310                 315                 320 


Val Leu Asp Ser Asp Ser Gly Val Glu Phe Thr Asn Gln Val Val His 
                325                 330                 335     


Glu Leu Asn Glu Leu Trp Pro Asp Leu Lys Ile Val Ser Gly Lys Tyr 
            340                 345                 350         


His Pro Gly Gln Ser Gln Gly Ser Leu Glu Gly Ala Ser Arg Asp Val 
        355                 360                 365             


Lys Asn Met Ile Ser Thr Trp Met Gln Ser Asn His Ser Cys His Trp 
    370                 375                 380                 


Ala Lys Gly Leu Arg Phe Met Gln Met Val Arg Asn Gln Ala Phe Asp 
385                 390                 395                 400 


Val Ser Leu Gln Gln Ser Pro Phe Glu Ala Met Phe Gly Tyr Lys Ala 
                405                 410                 415     


Lys Phe Gly Leu Tyr Ser Ser Asn Leu Pro Arg Glu Thr Val Ala Thr 
            420                 425                 430         


Leu Gln Thr Glu Glu Glu Leu Glu Ile Ala Glu Glu Gln Leu Glu Asn 
        435                 440                 445             


Ser Leu Trp Ile Arg Gln Glu Glu Arg Ala Glu Ile Gly Ala Asp Arg 
    450                 455                 460                 


Ser Asp Met Asp Asp Asp Met Asp Pro Thr Pro Glu Ala Ser Glu Pro 
465                 470                 475                 480 


Ser Thr Ser Gln Gly Thr Ser Gly Leu Leu Cys Trp 
                485                 490         


<210>  7604
<211>  462
<212>  PRT
<213>  Homo Sapiens

<400>  7604

Met Gly Thr Gln Ala Leu Gln Gly Phe Leu Phe Leu Leu Phe Leu Pro 
1               5                   10                  15      


Leu Leu Gln Pro Arg Gly Ala Ser Ala Gly Ser Leu His Ser Pro Gly 
            20                  25                  30          


Leu Ser Glu Cys Phe Gln Val Asn Gly Ala Asp Tyr Arg Gly His Gln 
        35                  40                  45              


Asn Arg Thr Gly Pro Arg Gly Ala Gly Arg Pro Cys Leu Phe Trp Asp 
    50                  55                  60                  


Gln Thr Gln Gln His Ser Tyr Ser Ser Ala Ser Asp Pro His Gly Arg 
65                  70                  75                  80  


Trp Gly Leu Gly Ala His Asn Phe Cys Arg Asn Pro Asp Gly Asp Val 
                85                  90                  95      


Gln Pro Trp Cys Tyr Val Ala Glu Thr Glu Glu Gly Ile Tyr Trp Arg 
            100                 105                 110         


Tyr Cys Asp Ile Pro Ser Cys His Met Pro Gly Tyr Leu Gly Cys Phe 
        115                 120                 125             


Val Asp Ser Gly Ala Pro Pro Ala Leu Ser Gly Pro Ser Gly Thr Ser 
    130                 135                 140                 


Thr Lys Leu Thr Val Gln Val Cys Leu Arg Phe Cys Arg Met Lys Gly 
145                 150                 155                 160 


Tyr Gln Leu Ala Gly Val Glu Ala Gly Tyr Ala Cys Phe Cys Gly Ser 
                165                 170                 175     


Glu Ser Asp Leu Ala Arg Gly Arg Leu Ala Pro Ala Thr Asp Cys Asp 
            180                 185                 190         


Gln Ile Cys Phe Gly His Pro Gly Gln Leu Cys Gly Gly Asp Gly Arg 
        195                 200                 205             


Leu Gly Val Tyr Glu Val Ser Val Gly Ser Cys Gln Gly Asn Trp Thr 
    210                 215                 220                 


Ala Pro Gln Gly Val Ile Tyr Ser Pro Asp Phe Pro Asp Glu Tyr Gly 
225                 230                 235                 240 


Pro Asp Arg Asn Cys Ser Trp Ala Leu Gly Pro Pro Gly Ala Ala Leu 
                245                 250                 255     


Glu Leu Thr Phe Arg Leu Phe Glu Leu Ala Asp Pro Arg Asp Arg Leu 
            260                 265                 270         


Glu Leu Arg Asp Ala Ala Ser Gly Ser Leu Leu Arg Ala Phe Asp Gly 
        275                 280                 285             


Ala Arg Pro Pro Pro Ser Gly Pro Leu Arg Leu Gly Thr Ala Ala Leu 
    290                 295                 300                 


Leu Leu Thr Phe Arg Ser Asp Ala Arg Gly His Ala Gln Gly Phe Ala 
305                 310                 315                 320 


Leu Thr Tyr Arg Gly Leu Gln Asp Ala Ala Glu Asp Pro Glu Ala Pro 
                325                 330                 335     


Glu Gly Ser Ala Gln Thr Pro Ala Ala Pro Leu Asp Gly Ala Asn Val 
            340                 345                 350         


Ser Cys Ser Pro Arg Pro Gly Ala Pro Pro Ala Ala Ile Gly Ala Arg 
        355                 360                 365             


Val Phe Ser Thr Val Thr Ala Val Ser Val Leu Leu Leu Leu Leu Leu 
    370                 375                 380                 


Gly Leu Leu Arg Pro Leu Arg Arg Arg Ser Cys Leu Leu Ala Pro Gly 
385                 390                 395                 400 


Lys Gly Pro Pro Ala Leu Gly Ala Ser Arg Gly Pro Arg Arg Ser Trp 
                405                 410                 415     


Ala Val Trp Tyr Gln Gln Pro Arg Gly Val Ala Leu Pro Cys Ser Pro 
            420                 425                 430         


Gly Asp Pro Gln Ala Glu Gly Ser Ala Ala Gly Tyr Arg Pro Leu Ser 
        435                 440                 445             


Ala Ser Ser Gln Ser Ser Leu Arg Ser Leu Ile Ser Ala Leu 
    450                 455                 460         


<210>  7605
<211>  420
<212>  PRT
<213>  Homo Sapiens

<400>  7605

Met Gly Thr Gln Ala Leu Gln Gly Phe Leu Phe Leu Leu Phe Leu Pro 
1               5                   10                  15      


Leu Leu Gln Pro Arg Gly Ala Ser Ala Gly Ser Leu His Ser Pro Gly 
            20                  25                  30          


Leu Ser Glu Cys Phe Gln Val Asn Gly Ala Asp Tyr Arg Gly His Gln 
        35                  40                  45              


Asn Arg Thr Gly Pro Arg Gly Ala Gly Arg Pro Cys Leu Phe Trp Asp 
    50                  55                  60                  


Gln Thr Gln Gln His Ser Tyr Ser Ser Ala Ser Asp Pro His Gly Arg 
65                  70                  75                  80  


Trp Gly Leu Gly Ala His Asn Phe Cys Arg Asn Pro Asp Gly Asp Val 
                85                  90                  95      


Gln Pro Trp Cys Tyr Val Ala Glu Thr Glu Glu Gly Ile Tyr Trp Arg 
            100                 105                 110         


Tyr Cys Asp Ile Pro Ser Cys His Met Pro Gly Tyr Leu Gly Cys Phe 
        115                 120                 125             


Val Asp Ser Gly Ala Pro Pro Ala Leu Ser Gly Pro Ser Gly Thr Ser 
    130                 135                 140                 


Thr Lys Leu Thr Val Gln Val Cys Leu Arg Phe Cys Arg Met Lys Gly 
145                 150                 155                 160 


Tyr Gln Leu Ala Gly Val Glu Ala Gly Tyr Ala Cys Phe Cys Gly Ser 
                165                 170                 175     


Glu Ser Asp Leu Ala Arg Gly Arg Leu Ala Pro Ala Thr Asp Cys Asp 
            180                 185                 190         


Gln Ile Cys Phe Gly His Pro Gly Gln Leu Cys Gly Gly Asp Gly Arg 
        195                 200                 205             


Leu Gly Val Tyr Glu Val Ser Val Gly Ser Cys Gln Gly Asn Trp Thr 
    210                 215                 220                 


Ala Pro Gln Gly Val Ile Tyr Ser Pro Asp Phe Pro Asp Glu Tyr Gly 
225                 230                 235                 240 


Pro Asp Arg Asn Cys Ser Trp Ala Leu Gly Pro Pro Gly Ala Ala Leu 
                245                 250                 255     


Glu Leu Thr Phe Arg Leu Phe Glu Leu Ala Asp Pro Arg Asp Arg Leu 
            260                 265                 270         


Glu Leu Arg Asp Ala Ala Ser Gly Ser Leu Leu Arg Ala Phe Asp Gly 
        275                 280                 285             


Ala Arg Pro Pro Pro Ser Gly Pro Leu Arg Leu Gly Thr Ala Ala Leu 
    290                 295                 300                 


Leu Leu Thr Phe Arg Ser Asp Ala Arg Gly His Ala Gln Gly Phe Ala 
305                 310                 315                 320 


Leu Thr Tyr Arg Gly Leu Gln Asp Ala Ala Glu Asp Pro Glu Ala Pro 
                325                 330                 335     


Glu Gly Ser Ala Gln Thr Pro Ala Ala Pro Leu Asp Gly Ala Asn Val 
            340                 345                 350         


Ser Cys Ser Pro Arg Pro Gly Ala Pro Pro Ala Ala Ile Gly Gly Ala 
        355                 360                 365             


Val Cys Trp Leu Arg Glu Lys Gly Pro Arg Arg Trp Gly Leu Pro Gly 
    370                 375                 380                 


Ala Pro Gly Glu Ala Gly Leu Cys Gly Thr Asn Ser Pro Glu Gly Trp 
385                 390                 395                 400 


Pro Cys Pro Ala Pro Pro Gly Thr Pro Arg Leu Arg Val Leu Pro Arg 
                405                 410                 415     


Ala Thr Gly Leu 
            420 


<210>  7606
<211>  399
<212>  PRT
<213>  Homo Sapiens

<400>  7606

Met Gly Thr Gln Ala Leu Gln Gly Phe Leu Phe Leu Leu Phe Leu Pro 
1               5                   10                  15      


Leu Leu Gln Pro Arg Gly Ala Ser Ala Gly Ser Leu His Ser Pro Gly 
            20                  25                  30          


Leu Ser Glu Cys Phe Gln Val Asn Gly Ala Asp Tyr Arg Gly His Gln 
        35                  40                  45              


Asn Arg Thr Gly Pro Arg Gly Ala Gly Arg Pro Cys Leu Phe Trp Asp 
    50                  55                  60                  


Gln Thr Gln Gln His Ser Tyr Ser Ser Ala Ser Asp Pro His Gly Arg 
65                  70                  75                  80  


Trp Gly Leu Gly Ala His Asn Phe Cys Arg Asn Pro Asp Gly Asp Val 
                85                  90                  95      


Gln Pro Trp Cys Tyr Val Ala Glu Thr Glu Glu Gly Ile Tyr Trp Arg 
            100                 105                 110         


Tyr Cys Asp Ile Pro Ser Cys His Met Pro Gly Tyr Leu Gly Cys Phe 
        115                 120                 125             


Val Asp Ser Gly Ala Pro Pro Ala Leu Ser Gly Pro Ser Gly Thr Ser 
    130                 135                 140                 


Thr Lys Leu Thr Val Gln Val Cys Leu Arg Phe Cys Arg Met Lys Gly 
145                 150                 155                 160 


Tyr Gln Leu Ala Gly Val Glu Ala Gly Tyr Ala Cys Phe Cys Gly Ser 
                165                 170                 175     


Glu Ser Asp Leu Ala Arg Gly Arg Leu Ala Pro Ala Thr Asp Cys Asp 
            180                 185                 190         


Gln Ile Cys Phe Gly His Pro Gly Gln Leu Cys Gly Gly Asp Gly Arg 
        195                 200                 205             


Leu Gly Val Tyr Glu Val Ser Val Gly Ser Cys Gln Gly Asn Trp Thr 
    210                 215                 220                 


Ala Pro Gln Gly Val Ile Tyr Ser Pro Asp Phe Pro Asp Glu Tyr Gly 
225                 230                 235                 240 


Pro Asp Arg Asn Cys Ser Trp Ala Leu Gly Pro Pro Gly Ala Ala Leu 
                245                 250                 255     


Glu Leu Thr Phe Arg Leu Phe Glu Leu Ala Asp Pro Arg Asp Arg Leu 
            260                 265                 270         


Glu Leu Arg Asp Ala Ala Ser Gly Ser Leu Leu Arg Ala Phe Asp Gly 
        275                 280                 285             


Ala Arg Pro Pro Pro Ser Gly Pro Leu Arg Leu Gly Thr Ala Ala Leu 
    290                 295                 300                 


Leu Leu Thr Phe Arg Ser Asp Ala Arg Gly His Ala Gln Gly Phe Ala 
305                 310                 315                 320 


Leu Thr Tyr Arg Gly Leu Gln Asp Ala Ala Glu Asp Pro Glu Ala Pro 
                325                 330                 335     


Glu Gly Ser Ala Gln Thr Pro Ala Ala Pro Leu Asp Gly Ala Asn Val 
            340                 345                 350         


Ser Cys Ser Pro Arg Pro Gly Ala Pro Pro Ala Ala Ile Gly Gly Glu 
        355                 360                 365             


Ala Gly Ala Arg Asp Gly Ser Glu Ser Gly Ser Arg Pro Leu Ala Pro 
    370                 375                 380                 


Ile Leu Thr Ala Ala Val Cys Pro Gln Pro Gly Ser Ser Arg Arg 
385                 390                 395                 


<210>  7607
<211>  424
<212>  PRT
<213>  Homo Sapiens

<400>  7607

Met Gly Thr Gln Ala Leu Gln Gly Phe Leu Phe Leu Leu Phe Leu Pro 
1               5                   10                  15      


Leu Leu Gln Pro Arg Gly Ala Ser Ala Gly Ser Leu His Ser Pro Gly 
            20                  25                  30          


Leu Ser Glu Cys Phe Gln Val Asn Gly Ala Asp Tyr Arg Gly His Gln 
        35                  40                  45              


Asn Arg Thr Gly Pro Arg Gly Ala Gly Arg Pro Cys Leu Phe Trp Asp 
    50                  55                  60                  


Gln Thr Gln Gln His Ser Tyr Ser Ser Ala Ser Asp Pro His Gly Arg 
65                  70                  75                  80  


Trp Gly Leu Gly Ala His Asn Phe Cys Arg Asn Pro Asp Gly Asp Val 
                85                  90                  95      


Gln Pro Trp Cys Tyr Val Ala Glu Thr Glu Glu Gly Ile Tyr Trp Arg 
            100                 105                 110         


Tyr Cys Asp Ile Pro Ser Cys His Met Pro Gly Tyr Leu Gly Cys Phe 
        115                 120                 125             


Val Asp Ser Gly Ala Pro Pro Ala Leu Ser Gly Pro Ser Gly Thr Ser 
    130                 135                 140                 


Thr Lys Leu Thr Val Gln Val Cys Leu Arg Phe Cys Arg Met Lys Gly 
145                 150                 155                 160 


Tyr Gln Leu Ala Gly Val Glu Ala Gly Tyr Ala Cys Phe Cys Gly Ser 
                165                 170                 175     


Glu Ser Asp Leu Ala Arg Gly Arg Leu Ala Pro Ala Thr Asp Cys Asp 
            180                 185                 190         


Gln Ile Cys Phe Gly His Pro Gly Gln Leu Cys Gly Gly Asp Gly Arg 
        195                 200                 205             


Leu Gly Val Tyr Glu Val Ser Val Gly Ser Cys Gln Gly Asn Trp Thr 
    210                 215                 220                 


Ala Pro Gln Gly Val Ile Tyr Ser Pro Asp Phe Pro Asp Glu Tyr Gly 
225                 230                 235                 240 


Pro Asp Arg Asn Cys Ser Trp Ala Leu Gly Pro Pro Gly Ala Ala Leu 
                245                 250                 255     


Glu Leu Thr Phe Arg Leu Phe Glu Leu Ala Asp Pro Arg Asp Arg Leu 
            260                 265                 270         


Glu Leu Arg Asp Ala Ala Ser Gly Ser Leu Leu Arg Ala Phe Asp Gly 
        275                 280                 285             


Ala Arg Pro Pro Pro Ser Gly Pro Leu Arg Leu Gly Thr Ala Ala Leu 
    290                 295                 300                 


Leu Leu Thr Phe Arg Ser Asp Ala Arg Gly His Ala Gln Gly Phe Ala 
305                 310                 315                 320 


Leu Thr Tyr Arg Gly Leu Gln Asp Ala Ala Glu Asp Pro Glu Ala Pro 
                325                 330                 335     


Glu Gly Ser Ala Gln Thr Pro Ala Ala Pro Leu Asp Gly Ala Asn Val 
            340                 345                 350         


Ser Cys Ser Pro Arg Pro Gly Ala Pro Pro Ala Ala Ile Gly Ala Arg 
        355                 360                 365             


Val Phe Ser Thr Val Thr Ala Val Ser Val Leu Leu Leu Leu Leu Leu 
    370                 375                 380                 


Gly Leu Leu Arg Pro Leu Arg Arg Arg Cys Gly Ala Leu Gly Gln Gly 
385                 390                 395                 400 


Leu Arg Ala Asp Arg Trp Trp Gly Ala Gly Ala Pro Glu Gly Asn Arg 
                405                 410                 415     


Ala Arg Lys Glu Leu Leu Gly Ser 
            420                 


<210>  7608
<211>  381
<212>  PRT
<213>  Homo Sapiens

<400>  7608

Met Gly Thr Gln Ala Leu Gln Gly Phe Leu Phe Leu Leu Phe Leu Pro 
1               5                   10                  15      


Leu Leu Gln Pro Arg Gly Ala Ser Ala Gly Ser Leu His Ser Pro Gly 
            20                  25                  30          


Leu Ser Glu Cys Phe Gln Val Asn Gly Ala Asp Tyr Arg Gly His Gln 
        35                  40                  45              


Asn Arg Thr Gly Pro Arg Gly Ala Gly Arg Pro Cys Leu Phe Trp Asp 
    50                  55                  60                  


Gln Thr Gln Gln His Ser Tyr Ser Ser Ala Ser Asp Pro His Gly Arg 
65                  70                  75                  80  


Trp Gly Leu Gly Ala His Asn Phe Cys Arg Asn Pro Asp Gly Asp Val 
                85                  90                  95      


Gln Pro Trp Cys Tyr Val Ala Glu Thr Glu Glu Gly Ile Tyr Trp Arg 
            100                 105                 110         


Tyr Cys Asp Ile Pro Ser Cys His Met Pro Gly Tyr Leu Gly Cys Phe 
        115                 120                 125             


Val Asp Ser Gly Ala Pro Pro Ala Leu Ser Gly Pro Ser Gly Thr Ser 
    130                 135                 140                 


Thr Lys Leu Thr Val Gln Val Cys Leu Arg Phe Cys Arg Met Lys Gly 
145                 150                 155                 160 


Tyr Gln Leu Cys Gly Gly Asp Gly Arg Leu Gly Val Tyr Glu Val Ser 
                165                 170                 175     


Val Gly Ser Cys Gln Gly Asn Trp Thr Ala Pro Gln Gly Val Ile Tyr 
            180                 185                 190         


Ser Pro Asp Phe Pro Asp Glu Tyr Gly Pro Asp Arg Asn Cys Ser Trp 
        195                 200                 205             


Ala Leu Gly Pro Pro Gly Ala Ala Leu Glu Leu Thr Phe Arg Leu Phe 
    210                 215                 220                 


Glu Leu Ala Asp Pro Arg Asp Arg Leu Glu Leu Arg Asp Ala Ala Ser 
225                 230                 235                 240 


Gly Ser Leu Leu Arg Ala Phe Asp Gly Ala Arg Pro Pro Pro Ser Gly 
                245                 250                 255     


Pro Leu Arg Leu Gly Thr Ala Ala Leu Leu Leu Thr Phe Arg Ser Asp 
            260                 265                 270         


Ala Arg Gly His Ala Gln Gly Phe Ala Leu Thr Tyr Arg Gly Leu Gln 
        275                 280                 285             


Asp Ala Ala Glu Asp Pro Glu Ala Pro Glu Gly Ser Ala Gln Thr Pro 
    290                 295                 300                 


Ala Ala Pro Leu Asp Gly Ala Asn Val Ser Cys Ser Pro Arg Pro Gly 
305                 310                 315                 320 


Ala Pro Pro Ala Ala Ile Gly Gly Ala Val Cys Trp Leu Arg Glu Lys 
                325                 330                 335     


Gly Pro Arg Arg Trp Gly Leu Pro Gly Ala Pro Gly Glu Ala Gly Leu 
            340                 345                 350         


Cys Gly Thr Asn Ser Pro Glu Gly Trp Pro Cys Pro Ala Pro Pro Gly 
        355                 360                 365             


Thr Pro Arg Leu Arg Val Leu Pro Arg Ala Thr Gly Leu 
    370                 375                 380     


<210>  7609
<211>  423
<212>  PRT
<213>  Homo Sapiens

<400>  7609

Met Gly Thr Gln Ala Leu Gln Gly Phe Leu Phe Leu Leu Phe Leu Pro 
1               5                   10                  15      


Leu Leu Gln Pro Arg Gly Ala Ser Ala Gly Ser Leu His Ser Pro Gly 
            20                  25                  30          


Leu Ser Glu Cys Phe Gln Val Asn Gly Ala Asp Tyr Arg Gly His Gln 
        35                  40                  45              


Asn Arg Thr Gly Pro Arg Gly Ala Gly Arg Pro Cys Leu Phe Trp Asp 
    50                  55                  60                  


Gln Thr Gln Gln His Ser Tyr Ser Ser Ala Ser Asp Pro His Gly Arg 
65                  70                  75                  80  


Trp Gly Leu Gly Ala His Asn Phe Cys Arg Asn Pro Asp Gly Asp Val 
                85                  90                  95      


Gln Pro Trp Cys Tyr Val Ala Glu Thr Glu Glu Gly Ile Tyr Trp Arg 
            100                 105                 110         


Tyr Cys Asp Ile Pro Ser Cys His Met Pro Gly Tyr Leu Gly Cys Phe 
        115                 120                 125             


Val Asp Ser Gly Ala Pro Pro Ala Leu Ser Gly Pro Ser Gly Thr Ser 
    130                 135                 140                 


Thr Lys Leu Thr Val Gln Val Cys Leu Arg Phe Cys Arg Met Lys Gly 
145                 150                 155                 160 


Tyr Gln Leu Cys Gly Gly Asp Gly Arg Leu Gly Val Tyr Glu Val Ser 
                165                 170                 175     


Val Gly Ser Cys Gln Gly Asn Trp Thr Ala Pro Gln Gly Val Ile Tyr 
            180                 185                 190         


Ser Pro Asp Phe Pro Asp Glu Tyr Gly Pro Asp Arg Asn Cys Ser Trp 
        195                 200                 205             


Ala Leu Gly Pro Pro Gly Ala Ala Leu Glu Leu Thr Phe Arg Leu Phe 
    210                 215                 220                 


Glu Leu Ala Asp Pro Arg Asp Arg Leu Glu Leu Arg Asp Ala Ala Ser 
225                 230                 235                 240 


Gly Ser Leu Leu Arg Ala Phe Asp Gly Ala Arg Pro Pro Pro Ser Gly 
                245                 250                 255     


Pro Leu Arg Leu Gly Thr Ala Ala Leu Leu Leu Thr Phe Arg Ser Asp 
            260                 265                 270         


Ala Arg Gly His Ala Gln Gly Phe Ala Leu Thr Tyr Arg Gly Leu Gln 
        275                 280                 285             


Asp Ala Ala Glu Asp Pro Glu Ala Pro Glu Gly Ser Ala Gln Thr Pro 
    290                 295                 300                 


Ala Ala Pro Leu Asp Gly Ala Asn Val Ser Cys Ser Pro Arg Pro Gly 
305                 310                 315                 320 


Ala Pro Pro Ala Ala Ile Gly Ala Arg Val Phe Ser Thr Val Thr Ala 
                325                 330                 335     


Val Ser Val Leu Leu Leu Leu Leu Leu Gly Leu Leu Arg Pro Leu Arg 
            340                 345                 350         


Arg Arg Ser Cys Leu Leu Ala Pro Gly Lys Gly Pro Pro Ala Leu Gly 
        355                 360                 365             


Ala Ser Arg Gly Pro Arg Arg Ser Trp Ala Val Trp Tyr Gln Gln Pro 
    370                 375                 380                 


Arg Gly Val Ala Leu Pro Cys Ser Pro Gly Asp Pro Gln Ala Glu Gly 
385                 390                 395                 400 


Ser Ala Ala Gly Tyr Arg Pro Leu Ser Ala Ser Ser Gln Ser Ser Leu 
                405                 410                 415     


Arg Ser Leu Ile Ser Ala Leu 
            420             


<210>  7610
<211>  85
<212>  PRT
<213>  Homo Sapiens

<400>  7610

Met Lys Ile Pro Val Leu Pro Ala Val Val Leu Leu Ser Leu Leu Val 
1               5                   10                  15      


Leu His Ser Ala Gln Gly Ala Thr Leu Gly Gly Pro Glu Glu Glu Ser 
            20                  25                  30          


Thr Ile Glu Asn Tyr Ala Ser Arg Pro Glu Ala Phe Lys Ala Asp Glu 
        35                  40                  45              


Phe Leu Asn Trp His Ala Leu Phe Glu Ser Ile Lys Arg Lys Leu Pro 
    50                  55                  60                  


Phe Leu Asn Trp Asp Ala Phe Pro Lys Leu Lys Gly Leu Arg Ser Ala 
65                  70                  75                  80  


Thr Pro Asp Ala Gln 
                85  


<210>  7611
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  7611

Met Lys Ile Pro Val Leu Pro Ala Val Val Leu Leu Ser Leu Leu Val 
1               5                   10                  15      


Leu His Ser Ala Gln Gly Ala Thr Leu Gly Gly Pro Glu Glu Glu Ser 
            20                  25                  30          


Thr Ile Glu Asn Tyr Ala Ser Arg Pro Glu Ala Phe Asn Thr Pro Phe 
        35                  40                  45              


Leu Asn Ile Asp Lys Leu Arg Ser Ala Phe Lys Ala Asp Glu Phe Leu 
    50                  55                  60                  


Asn Trp His Ala Leu Phe Glu Ser Ile Lys Arg Lys Leu Pro Phe Leu 
65                  70                  75                  80  


Asn Trp Asp Ala Phe Pro Lys Leu Lys Gly Leu Arg Ser Ala Thr Pro 
                85                  90                  95      


Asp Ala Gln 
            


<210>  7612
<211>  153
<212>  PRT
<213>  Homo Sapiens

<400>  7612

Glu Glu Lys Gly Gly Ala Ser Leu Ser Pro Gln Tyr Val Ser Tyr Asn 
1               5                   10                  15      


Gln Ser Ser Tyr Thr Gln Trp Asp Leu Gln Pro Asp Thr Asp Tyr Glu 
            20                  25                  30          


Ile His Leu Phe Lys Glu Arg Met Phe Arg His Gln Met Ala Val Lys 
        35                  40                  45              


Thr Asn Gly Thr Val Lys Asp Lys Glu Asp Thr Gln Val Asp Ser Glu 
    50                  55                  60                  


Ala Arg Pro Met Lys Asp Glu Thr Phe Gly Glu Tyr Ser Asp Asn Glu 
65                  70                  75                  80  


Glu Lys Ala Phe Gly Ser Ser Gln Pro Ser Leu Asn Gly Asp Ile Lys 
                85                  90                  95      


Pro Leu Gly Ser Asp Asp Ser Leu Ala Asp Tyr Gly Gly Ser Val Asp 
            100                 105                 110         


Val Gln Phe Asn Glu Asp Gly Ser Phe Ile Gly Gln Tyr Ser Gly Lys 
        115                 120                 125             


Lys Glu Lys Glu Ala Ala Gly Gly Asn Asp Ser Ser Gly Ala Thr Ser 
    130                 135                 140                 


Pro Ile Asn Pro Ala Val Ala Leu Glu 
145                 150             


<210>  7613
<211>  90
<212>  PRT
<213>  Homo Sapiens

<400>  7613

Met Val Val Ala Leu Arg Tyr Val Trp Pro Leu Leu Leu Cys Ser Pro 
1               5                   10                  15      


Cys Leu Leu Ile Gln Ile Pro Glu Glu Leu Met Glu Pro Pro Val Ile 
            20                  25                  30          


Thr Glu Gln Ser Pro Arg Arg Leu Val Val Phe Pro Thr Asp Asp Ile 
        35                  40                  45              


Ser Leu Lys Cys Glu Ala Ser Gly Lys Pro Glu Val Gln Phe Arg Trp 
    50                  55                  60                  


Thr Arg Asp Gly Val His Phe Lys Pro Lys Glu Glu Leu Gly Val Thr 
65                  70                  75                  80  


Val Tyr Gln Ser Pro His Ser Gly Ser Phe 
                85                  90  


<210>  7614
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  7614

Met Val Val Ala Leu Arg Tyr Val Trp Pro Leu Leu Leu Cys Ser Pro 
1               5                   10                  15      


Cys Leu Leu Ile Gln Ile Pro Glu Glu Leu Met Glu Pro Pro Val Ile 
            20                  25                  30          


Thr Glu Gln Ser Pro Arg Arg Leu Val Val Phe Pro Thr Asp Asp Ile 
        35                  40                  45              


Ser Leu Lys Cys Glu Ala Ser Gly Lys Pro Glu Val Gln Phe Arg Trp 
    50                  55                  60                  


Thr Arg Asp Gly Val His Phe Lys Pro Lys Glu Glu Leu Gly Val Thr 
65                  70                  75                  80  


Val Tyr Gln Ser Pro His Ser Gly Ser Phe Thr Ile Thr Gly Asn Asn 
                85                  90                  95      


Ser Asn Phe Ala Gln Arg Phe Gln Gly Ile Tyr Arg Cys Phe Ala Ser 
            100                 105                 110         


Asn Lys Leu Gly Thr Ala Met Ser His Glu Ile Arg Leu Met Ala Glu 
        115                 120                 125             


<210>  7615
<211>  1248
<212>  PRT
<213>  Homo Sapiens

<400>  7615

Met Val Val Ala Leu Arg Tyr Val Trp Pro Leu Leu Leu Cys Ser Pro 
1               5                   10                  15      


Cys Leu Leu Ile Gln Ile Pro Glu Glu Leu Met Glu Pro Pro Val Ile 
            20                  25                  30          


Thr Glu Gln Ser Pro Arg Arg Leu Val Val Phe Pro Thr Asp Asp Ile 
        35                  40                  45              


Ser Leu Lys Cys Glu Ala Ser Gly Lys Pro Glu Val Gln Phe Arg Trp 
    50                  55                  60                  


Thr Arg Asp Gly Val His Phe Lys Pro Lys Glu Glu Leu Gly Val Thr 
65                  70                  75                  80  


Val Tyr Gln Ser Pro His Ser Gly Ser Phe Thr Ile Thr Gly Asn Asn 
                85                  90                  95      


Ser Asn Phe Ala Gln Arg Phe Gln Gly Ile Tyr Arg Cys Phe Ala Ser 
            100                 105                 110         


Asn Lys Leu Gly Thr Ala Met Ser His Glu Ile Arg Leu Met Ala Glu 
        115                 120                 125             


Gly Ala Pro Lys Trp Pro Lys Glu Thr Val Lys Pro Val Glu Val Glu 
    130                 135                 140                 


Glu Gly Glu Ser Val Val Leu Pro Cys Asn Pro Pro Pro Ser Ala Glu 
145                 150                 155                 160 


Pro Leu Arg Ile Tyr Trp Met Asn Ser Lys Ile Leu His Ile Lys Gln 
                165                 170                 175     


Asp Glu Arg Val Thr Met Gly Gln Asn Gly Asn Leu Tyr Phe Ala Asn 
            180                 185                 190         


Val Leu Thr Ser Asp Asn His Ser Asp Tyr Ile Cys His Ala His Phe 
        195                 200                 205             


Pro Gly Thr Arg Thr Ile Ile Gln Lys Glu Pro Ile Asp Leu Arg Val 
    210                 215                 220                 


Lys Ala Thr Asn Ser Met Ile Asp Arg Lys Pro Arg Leu Leu Phe Pro 
225                 230                 235                 240 


Thr Asn Ser Ser Ser His Leu Val Ala Leu Gln Gly Gln Pro Leu Val 
                245                 250                 255     


Leu Glu Cys Ile Ala Glu Gly Phe Pro Thr Pro Thr Ile Lys Trp Leu 
            260                 265                 270         


Arg Pro Ser Gly Pro Met Pro Ala Asp Arg Val Thr Tyr Gln Asn His 
        275                 280                 285             


Asn Lys Thr Leu Gln Leu Leu Lys Val Gly Glu Glu Asp Asp Gly Glu 
    290                 295                 300                 


Tyr Arg Cys Leu Ala Glu Asn Ser Leu Gly Ser Ala Arg His Ala Tyr 
305                 310                 315                 320 


Tyr Val Thr Val Glu Ala Ala Pro Tyr Trp Leu His Lys Pro Gln Ser 
                325                 330                 335     


His Leu Tyr Gly Pro Gly Glu Thr Ala Arg Leu Asp Cys Gln Val Gln 
            340                 345                 350         


Gly Arg Pro Gln Pro Glu Val Thr Trp Arg Ile Asn Gly Ile Pro Val 
        355                 360                 365             


Glu Glu Leu Ala Lys Asp Gln Lys Tyr Arg Ile Gln Arg Gly Ala Leu 
    370                 375                 380                 


Ile Leu Ser Asn Val Gln Pro Ser Asp Thr Met Val Thr Gln Cys Glu 
385                 390                 395                 400 


Ala Arg Asn Arg His Gly Leu Leu Leu Ala Asn Ala Tyr Ile Tyr Val 
                405                 410                 415     


Val Gln Leu Pro Ala Lys Ile Leu Thr Ala Asp Asn Gln Thr Tyr Met 
            420                 425                 430         


Ala Val Gln Gly Ser Thr Ala Tyr Leu Leu Cys Lys Ala Phe Gly Ala 
        435                 440                 445             


Pro Val Pro Ser Val Gln Trp Leu Asp Glu Asp Gly Thr Thr Val Leu 
    450                 455                 460                 


Gln Asp Glu Arg Phe Phe Pro Tyr Ala Asn Gly Thr Leu Gly Ile Arg 
465                 470                 475                 480 


Asp Leu Gln Ala Asn Asp Thr Gly Arg Tyr Phe Cys Leu Ala Ala Asn 
                485                 490                 495     


Asp Gln Asn Asn Val Thr Ile Met Ala Asn Leu Lys Val Lys Asp Ala 
            500                 505                 510         


Thr Gln Ile Thr Gln Gly Pro Arg Ser Thr Ile Glu Lys Lys Gly Ser 
        515                 520                 525             


Arg Val Thr Phe Thr Cys Gln Ala Ser Phe Asp Pro Ser Leu Gln Pro 
    530                 535                 540                 


Ser Ile Thr Trp Arg Gly Asp Gly Arg Asp Leu Gln Glu Leu Gly Asp 
545                 550                 555                 560 


Ser Asp Lys Tyr Phe Ile Glu Asp Gly Arg Leu Val Ile His Ser Leu 
                565                 570                 575     


Asp Tyr Ser Asp Gln Gly Asn Tyr Ser Cys Val Ala Ser Thr Glu Leu 
            580                 585                 590         


Asp Val Val Glu Ser Arg Ala Gln Leu Leu Val Val Gly Ser Pro Gly 
        595                 600                 605             


Pro Val Pro Arg Leu Val Leu Ser Asp Leu His Leu Leu Thr Gln Ser 
    610                 615                 620                 


Gln Val Arg Val Ser Trp Ser Pro Ala Glu Asp His Asn Ala Pro Ile 
625                 630                 635                 640 


Glu Lys Tyr Asp Ile Glu Phe Glu Asp Lys Glu Met Ala Pro Glu Lys 
                645                 650                 655     


Trp Tyr Ser Leu Gly Lys Val Pro Gly Asn Gln Thr Ser Thr Thr Leu 
            660                 665                 670         


Lys Leu Ser Pro Tyr Val His Tyr Thr Phe Arg Val Thr Ala Ile Asn 
        675                 680                 685             


Lys Tyr Gly Pro Gly Glu Pro Ser Pro Val Ser Glu Thr Val Val Thr 
    690                 695                 700                 


Pro Glu Ala Ala Pro Glu Lys Asn Pro Val Asp Val Lys Gly Glu Gly 
705                 710                 715                 720 


Asn Glu Thr Thr Asn Met Val Ile Thr Trp Lys Pro Leu Arg Trp Met 
                725                 730                 735     


Asp Trp Asn Ala Pro Gln Val Gln Tyr Arg Val Gln Trp Arg Pro Gln 
            740                 745                 750         


Gly Thr Arg Gly Pro Trp Gln Glu Gln Ile Val Ser Asp Pro Phe Leu 
        755                 760                 765             


Val Val Ser Asn Thr Ser Thr Phe Val Pro Tyr Glu Ile Lys Val Gln 
    770                 775                 780                 


Ala Val Asn Ser Gln Gly Lys Gly Pro Glu Pro Gln Val Thr Ile Gly 
785                 790                 795                 800 


Tyr Ser Gly Glu Asp Tyr Pro Gln Ala Ile Pro Glu Leu Glu Gly Ile 
                805                 810                 815     


Glu Ile Leu Asn Ser Ser Ala Val Leu Val Lys Trp Arg Pro Val Asp 
            820                 825                 830         


Leu Ala Gln Val Lys Gly His Leu Arg Gly Tyr Asn Val Thr Tyr Trp 
        835                 840                 845             


Arg Glu Gly Ser Gln Arg Lys His Ser Lys Arg His Ile His Lys Asp 
    850                 855                 860                 


His Val Val Val Pro Ala Asn Thr Thr Ser Val Ile Leu Ser Gly Leu 
865                 870                 875                 880 


Arg Pro Tyr Ser Ser Tyr His Leu Glu Val Gln Ala Phe Asn Gly Arg 
                885                 890                 895     


Gly Ser Gly Pro Ala Ser Glu Phe Thr Phe Ser Thr Pro Glu Gly Val 
            900                 905                 910         


Pro Gly His Pro Glu Ala Leu His Leu Glu Cys Gln Ser Asn Thr Ser 
        915                 920                 925             


Leu Leu Leu Arg Trp Gln Pro Pro Leu Ser His Asn Gly Val Leu Thr 
    930                 935                 940                 


Gly Tyr Val Leu Ser Tyr His Pro Leu Asp Glu Gly Gly Lys Gly Gln 
945                 950                 955                 960 


Leu Ser Phe Asn Leu Arg Asp Pro Glu Leu Arg Thr His Asn Leu Thr 
                965                 970                 975     


Asp Leu Ser Pro His Leu Arg Tyr Arg Phe Gln Leu Gln Ala Thr Thr 
            980                 985                 990         


Lys Glu Gly Pro Gly Glu Ala Ile  Val Arg Glu Gly Gly  Thr Met Ala 
        995                 1000                 1005             


Leu Ser  Gly Ile Ser Asp Phe  Gly Asn Ile Ser Ala  Thr Ala Gly 
    1010                 1015                 1020             


Glu Asn  Tyr Ser Val Val Ser  Trp Val Pro Lys Glu  Gly Gln Cys 
    1025                 1030                 1035             


Asn Phe  Arg Phe His Ile Leu  Phe Lys Ala Leu Gly  Glu Glu Lys 
    1040                 1045                 1050             


Gly Gly  Ala Ser Leu Ser Pro  Gln Tyr Val Ser Tyr  Asn Gln Ser 
    1055                 1060                 1065             


Ser Tyr  Thr Gln Trp Asp Leu  Gln Pro Asp Thr Asp  Tyr Glu Ile 
    1070                 1075                 1080             


His Leu  Phe Lys Glu Arg Met  Phe Arg His Gln Met  Ala Val Lys 
    1085                 1090                 1095             


Thr Asn  Gly Thr Gly Arg Val  Arg Leu Pro Pro Ala  Gly Phe Ala 
    1100                 1105                 1110             


Thr Glu  Gly Trp Phe Ile Gly  Phe Val Ser Ala Ile  Ile Leu Leu 
    1115                 1120                 1125             


Leu Leu  Val Leu Leu Ile Leu  Cys Phe Ile Lys Arg  Ser Lys Gly 
    1130                 1135                 1140             


Gly Lys  Tyr Ser Val Lys Asp  Lys Glu Asp Thr Gln  Val Asp Ser 
    1145                 1150                 1155             


Glu Ala  Arg Pro Met Lys Asp  Glu Thr Phe Gly Glu  Tyr Ser Asp 
    1160                 1165                 1170             


Asn Glu  Glu Lys Ala Phe Gly  Ser Ser Gln Pro Ser  Leu Asn Gly 
    1175                 1180                 1185             


Asp Ile  Lys Pro Leu Gly Ser  Asp Asp Ser Leu Ala  Asp Tyr Gly 
    1190                 1195                 1200             


Gly Ser  Val Asp Val Gln Phe  Asn Glu Asp Gly Ser  Phe Ile Gly 
    1205                 1210                 1215             


Gln Tyr  Ser Gly Lys Lys Glu  Lys Glu Ala Ala Gly  Gly Asn Asp 
    1220                 1225                 1230             


Ser Ser  Gly Ala Thr Ser Pro  Ile Asn Pro Ala Val  Ala Leu Glu 
    1235                 1240                 1245             


<210>  7616
<211>  1248
<212>  PRT
<213>  Homo Sapiens

<400>  7616

Met Val Val Ala Leu Arg Tyr Val Trp Pro Leu Leu Leu Cys Ser Pro 
1               5                   10                  15      


Cys Leu Leu Ile Gln Ile Pro Glu Glu Leu Met Glu Pro Pro Val Ile 
            20                  25                  30          


Thr Glu Gln Ser Pro Arg Arg Leu Val Val Phe Pro Thr Asp Asp Ile 
        35                  40                  45              


Ser Leu Lys Cys Glu Ala Ser Gly Lys Pro Glu Val Gln Phe Arg Trp 
    50                  55                  60                  


Thr Arg Asp Gly Val His Phe Lys Pro Lys Glu Glu Leu Gly Val Thr 
65                  70                  75                  80  


Val Tyr Gln Ser Pro His Ser Gly Ser Phe Thr Ile Thr Gly Asn Asn 
                85                  90                  95      


Ser Asn Phe Ala Gln Arg Phe Gln Gly Ile Tyr Arg Cys Phe Ala Ser 
            100                 105                 110         


Asn Lys Leu Gly Thr Ala Met Ser His Glu Ile Arg Leu Met Ala Glu 
        115                 120                 125             


Gly Ala Pro Lys Trp Pro Lys Glu Thr Val Lys Pro Val Glu Val Glu 
    130                 135                 140                 


Glu Gly Glu Ser Val Val Leu Pro Cys Asn Pro Pro Pro Ser Ala Glu 
145                 150                 155                 160 


Pro Leu Arg Ile Tyr Trp Met Asn Ser Lys Ile Leu His Ile Lys Gln 
                165                 170                 175     


Asp Glu Arg Val Thr Met Gly Gln Asn Gly Asn Leu Tyr Phe Ala Asn 
            180                 185                 190         


Val Leu Thr Ser Asp Asn His Ser Asp Tyr Ile Cys His Ala His Phe 
        195                 200                 205             


Pro Gly Thr Arg Thr Ile Ile Gln Lys Glu Pro Ile Asp Leu Arg Val 
    210                 215                 220                 


Lys Ala Thr Asn Ser Met Ile Asp Arg Lys Pro Arg Leu Leu Phe Pro 
225                 230                 235                 240 


Thr Asn Ser Ser Ser His Leu Val Ala Leu Gln Gly Gln Pro Leu Val 
                245                 250                 255     


Leu Glu Cys Ile Ala Glu Gly Phe Pro Thr Pro Thr Ile Lys Trp Leu 
            260                 265                 270         


Arg Pro Ser Gly Pro Met Pro Ala Asp Arg Val Thr Tyr Gln Asn His 
        275                 280                 285             


Asn Lys Thr Leu Gln Leu Leu Lys Val Gly Glu Glu Asp Asp Gly Glu 
    290                 295                 300                 


Tyr Arg Cys Leu Ala Glu Asn Ser Leu Gly Ser Ala Arg His Ala Tyr 
305                 310                 315                 320 


Tyr Val Thr Val Glu Ala Ala Pro Tyr Trp Leu His Lys Pro Gln Ser 
                325                 330                 335     


His Leu Tyr Gly Pro Gly Glu Thr Ala Arg Leu Asp Cys Gln Val Gln 
            340                 345                 350         


Gly Arg Pro Gln Pro Glu Val Thr Trp Arg Ile Asn Gly Ile Pro Val 
        355                 360                 365             


Glu Glu Leu Ala Lys Asp Gln Lys Tyr Arg Ile Gln Arg Gly Ala Leu 
    370                 375                 380                 


Ile Leu Ser Asn Val Gln Pro Ser Asp Thr Met Val Thr Gln Cys Glu 
385                 390                 395                 400 


Ala Arg Asn Arg His Gly Leu Leu Leu Ala Asn Ala Tyr Ile Tyr Val 
                405                 410                 415     


Val Gln Leu Pro Ala Lys Ile Leu Thr Ala Asp Asn Gln Thr Tyr Met 
            420                 425                 430         


Ala Val Gln Gly Ser Thr Ala Tyr Leu Leu Cys Lys Ala Phe Gly Ala 
        435                 440                 445             


Pro Val Pro Ser Val Gln Trp Leu Asp Glu Asp Gly Thr Thr Val Leu 
    450                 455                 460                 


Gln Asp Glu Arg Phe Phe Pro Tyr Ala Asn Gly Thr Leu Gly Ile Arg 
465                 470                 475                 480 


Asp Leu Gln Ala Asn Asp Thr Gly Arg Tyr Phe Cys Leu Ala Ala Asn 
                485                 490                 495     


Asp Gln Asn Asn Val Thr Ile Met Ala Asn Leu Lys Val Lys Asp Ala 
            500                 505                 510         


Thr Gln Ile Thr Gln Gly Pro Arg Ser Thr Ile Glu Lys Lys Gly Ser 
        515                 520                 525             


Arg Val Thr Phe Thr Cys Gln Ala Ser Phe Asp Pro Ser Leu Gln Pro 
    530                 535                 540                 


Ser Ile Thr Trp Arg Gly Asp Gly Arg Asp Leu Gln Glu Leu Gly Asp 
545                 550                 555                 560 


Ser Asp Lys Tyr Phe Ile Glu Asp Gly Arg Leu Val Ile His Ser Leu 
                565                 570                 575     


Asp Tyr Ser Asp Gln Gly Asn Tyr Ser Cys Val Ala Ser Thr Glu Leu 
            580                 585                 590         


Asp Val Val Glu Ser Arg Ala Gln Leu Leu Val Val Gly Ser Pro Gly 
        595                 600                 605             


Pro Val Pro Arg Leu Val Leu Ser Asp Leu His Leu Leu Thr Gln Ser 
    610                 615                 620                 


Gln Val Arg Val Ser Trp Ser Pro Ala Glu Asp His Asn Ala Pro Ile 
625                 630                 635                 640 


Glu Lys Tyr Asp Ile Glu Phe Glu Asp Lys Glu Met Ala Pro Glu Lys 
                645                 650                 655     


Trp Tyr Ser Leu Gly Lys Val Pro Gly Asn Gln Thr Ser Thr Thr Leu 
            660                 665                 670         


Lys Leu Ser Pro Tyr Val His Tyr Thr Phe Arg Val Thr Ala Ile Asn 
        675                 680                 685             


Lys Tyr Gly Pro Gly Glu Pro Ser Pro Val Ser Glu Thr Val Val Thr 
    690                 695                 700                 


Pro Glu Ala Ala Pro Glu Lys Asn Pro Val Asp Val Lys Gly Glu Gly 
705                 710                 715                 720 


Asn Glu Thr Thr Asn Met Val Ile Thr Trp Lys Pro Leu Arg Trp Met 
                725                 730                 735     


Asp Trp Asn Ala Pro Gln Val Gln Tyr Arg Val Gln Trp Arg Pro Gln 
            740                 745                 750         


Gly Thr Arg Gly Pro Trp Gln Glu Gln Ile Val Ser Asp Pro Phe Leu 
        755                 760                 765             


Val Val Ser Asn Thr Ser Thr Phe Val Pro Tyr Glu Ile Lys Val Gln 
    770                 775                 780                 


Ala Val Asn Ser Gln Gly Lys Gly Pro Glu Pro Gln Val Thr Ile Gly 
785                 790                 795                 800 


Tyr Ser Gly Glu Asp Tyr Pro Gln Ala Ile Pro Glu Leu Glu Gly Ile 
                805                 810                 815     


Glu Ile Leu Asn Ser Ser Ala Val Leu Val Lys Trp Arg Pro Val Asp 
            820                 825                 830         


Leu Ala Gln Val Lys Gly His Leu Arg Gly Tyr Asn Val Thr Tyr Trp 
        835                 840                 845             


Arg Glu Gly Ser Gln Arg Lys His Ser Lys Arg His Ile His Lys Asp 
    850                 855                 860                 


His Val Val Val Pro Ala Asn Thr Thr Ser Val Ile Leu Ser Gly Leu 
865                 870                 875                 880 


Arg Pro Tyr Ser Ser Tyr His Leu Glu Val Gln Ala Phe Asn Gly Arg 
                885                 890                 895     


Gly Ser Gly Pro Ala Ser Glu Phe Thr Phe Ser Thr Pro Glu Gly Val 
            900                 905                 910         


Pro Gly His Pro Glu Ala Leu His Leu Glu Cys Gln Ser Asn Thr Ser 
        915                 920                 925             


Leu Leu Leu Arg Trp Gln Pro Pro Leu Ser His Asn Gly Val Leu Thr 
    930                 935                 940                 


Gly Tyr Val Leu Ser Tyr His Pro Leu Asp Glu Gly Gly Lys Gly Gln 
945                 950                 955                 960 


Leu Ser Phe Asn Leu Arg Asp Pro Glu Leu Arg Thr His Asn Leu Thr 
                965                 970                 975     


Asp Leu Ser Pro His Leu Arg Tyr Arg Phe Gln Leu Gln Ala Thr Thr 
            980                 985                 990         


Lys Glu Gly Pro Gly Glu Ala Ile  Val Arg Glu Gly Gly  Thr Met Ala 
        995                 1000                 1005             


Leu Ser  Gly Ile Ser Asp Phe  Gly Asn Ile Ser Ala  Thr Ala Gly 
    1010                 1015                 1020             


Glu Asn  Tyr Ser Val Val Ser  Trp Val Pro Lys Glu  Gly Gln Cys 
    1025                 1030                 1035             


Asn Phe  Arg Phe His Ile Leu  Phe Lys Ala Leu Gly  Glu Glu Lys 
    1040                 1045                 1050             


Gly Gly  Ala Ser Leu Ser Pro  Gln Tyr Val Ser Tyr  Asn Gln Ser 
    1055                 1060                 1065             


Ser Tyr  Thr Gln Trp Asp Leu  Gln Pro Asp Thr Asp  Tyr Glu Ile 
    1070                 1075                 1080             


His Leu  Phe Lys Glu Arg Met  Phe Arg His Gln Met  Ala Val Lys 
    1085                 1090                 1095             


Thr Asn  Gly Thr Gly Arg Val  Arg Leu Pro Pro Ala  Gly Phe Ala 
    1100                 1105                 1110             


Thr Glu  Gly Trp Phe Ile Gly  Phe Val Ser Ala Ile  Ile Leu Leu 
    1115                 1120                 1125             


Leu Leu  Val Leu Leu Ile Leu  Cys Phe Ile Lys Arg  Ser Lys Gly 
    1130                 1135                 1140             


Gly Lys  Tyr Ser Val Lys Asp  Lys Glu Asp Thr Gln  Val Asp Ser 
    1145                 1150                 1155             


Glu Ala  Arg Pro Met Lys Asp  Glu Thr Phe Gly Glu  Tyr Ser Asp 
    1160                 1165                 1170             


Asn Glu  Glu Lys Ala Phe Gly  Ser Ser Gln Pro Ser  Leu Asn Gly 
    1175                 1180                 1185             


Asp Ile  Lys Pro Leu Gly Ser  Asp Asp Ser Leu Ala  Asp Tyr Gly 
    1190                 1195                 1200             


Gly Ser  Val Asp Val Gln Phe  Asn Glu Asp Gly Ser  Phe Ile Gly 
    1205                 1210                 1215             


Gln Tyr  Ser Gly Lys Lys Glu  Lys Glu Ala Ala Gly  Gly Asn Asp 
    1220                 1225                 1230             


Ser Ser  Gly Ala Thr Ser Pro  Ile Asn Pro Ala Val  Ala Leu Glu 
    1235                 1240                 1245             


<210>  7617
<211>  84
<212>  PRT
<213>  Homo Sapiens

<400>  7617

Met Val Val Ala Leu Arg Tyr Val Trp Pro Leu Leu Leu Cys Ser Pro 
1               5                   10                  15      


Cys Leu Leu Ile Gln Ile Pro Glu Glu Tyr Glu Gly His His Val Met 
            20                  25                  30          


Glu Pro Pro Val Ile Thr Glu Gln Ser Pro Arg Arg Leu Val Val Phe 
        35                  40                  45              


Pro Thr Asp Asp Ile Ser Leu Lys Cys Glu Ala Ser Gly Lys Pro Glu 
    50                  55                  60                  


Val Gln Phe Arg Trp Thr Arg Asp Gly Val His Phe Lys Pro Lys Glu 
65                  70                  75                  80  


Glu Leu Gly Val 
                


<210>  7618
<211>  151
<212>  PRT
<213>  Homo Sapiens

<400>  7618

Met Val Val Ala Leu Arg Tyr Val Trp Pro Leu Leu Leu Cys Ser Pro 
1               5                   10                  15      


Cys Leu Leu Ile Gln Ile Pro Glu Glu Tyr Glu Gly His His Val Met 
            20                  25                  30          


Glu Pro Pro Val Ile Thr Glu Gln Ser Pro Arg Arg Leu Val Val Phe 
        35                  40                  45              


Pro Thr Asp Asp Ile Ser Leu Lys Cys Glu Ala Ser Gly Lys Pro Glu 
    50                  55                  60                  


Val Gln Phe Arg Trp Thr Arg Asp Gly Val His Phe Lys Pro Lys Glu 
65                  70                  75                  80  


Glu Leu Gly Val Thr Val Tyr Gln Ser Pro His Ser Gly Ser Phe Thr 
                85                  90                  95      


Ile Thr Gly Asn Asn Ser Asn Phe Ala Gln Arg Phe Gln Gly Ile Tyr 
            100                 105                 110         


Arg Cys Phe Ala Ser Asn Lys Leu Gly Thr Ala Met Ser His Glu Ile 
        115                 120                 125             


Arg Leu Met Ala Glu Gly Ala Pro Lys Trp Pro Lys Glu Thr Val Lys 
    130                 135                 140                 


Pro Val Glu Val Glu Glu Gly 
145                 150     


<210>  7619
<211>  1253
<212>  PRT
<213>  Homo Sapiens

<400>  7619

Met Val Val Ala Leu Arg Tyr Val Trp Pro Leu Leu Leu Cys Ser Pro 
1               5                   10                  15      


Cys Leu Leu Ile Gln Ile Pro Glu Glu Tyr Glu Gly His His Val Met 
            20                  25                  30          


Glu Pro Pro Val Ile Thr Glu Gln Ser Pro Arg Arg Leu Val Val Phe 
        35                  40                  45              


Pro Thr Asp Asp Ile Ser Leu Lys Cys Glu Ala Ser Gly Lys Pro Glu 
    50                  55                  60                  


Val Gln Phe Arg Trp Thr Arg Asp Gly Val His Phe Lys Pro Lys Glu 
65                  70                  75                  80  


Glu Leu Gly Val Thr Val Tyr Gln Ser Pro His Ser Gly Ser Phe Thr 
                85                  90                  95      


Ile Thr Gly Asn Asn Ser Asn Phe Ala Gln Arg Phe Gln Gly Ile Tyr 
            100                 105                 110         


Arg Cys Phe Ala Ser Asn Lys Leu Gly Thr Ala Met Ser His Glu Ile 
        115                 120                 125             


Arg Leu Met Ala Glu Gly Ala Pro Lys Trp Pro Lys Glu Thr Val Lys 
    130                 135                 140                 


Pro Val Glu Val Glu Glu Gly Glu Ser Val Val Leu Pro Cys Asn Pro 
145                 150                 155                 160 


Pro Pro Ser Ala Glu Pro Leu Arg Ile Tyr Trp Met Asn Ser Lys Ile 
                165                 170                 175     


Leu His Ile Lys Gln Asp Glu Arg Val Thr Met Gly Gln Asn Gly Asn 
            180                 185                 190         


Leu Tyr Phe Ala Asn Val Leu Thr Ser Asp Asn His Ser Asp Tyr Ile 
        195                 200                 205             


Cys His Ala His Phe Pro Gly Thr Arg Thr Ile Ile Gln Lys Glu Pro 
    210                 215                 220                 


Ile Asp Leu Arg Val Lys Ala Thr Asn Ser Met Ile Asp Arg Lys Pro 
225                 230                 235                 240 


Arg Leu Leu Phe Pro Thr Asn Ser Ser Ser His Leu Val Ala Leu Gln 
                245                 250                 255     


Gly Gln Pro Leu Val Leu Glu Cys Ile Ala Glu Gly Phe Pro Thr Pro 
            260                 265                 270         


Thr Ile Lys Trp Leu Arg Pro Ser Gly Pro Met Pro Ala Asp Arg Val 
        275                 280                 285             


Thr Tyr Gln Asn His Asn Lys Thr Leu Gln Leu Leu Lys Val Gly Glu 
    290                 295                 300                 


Glu Asp Asp Gly Glu Tyr Arg Cys Leu Ala Glu Asn Ser Leu Gly Ser 
305                 310                 315                 320 


Ala Arg His Ala Tyr Tyr Val Thr Val Glu Ala Ala Pro Tyr Trp Leu 
                325                 330                 335     


His Lys Pro Gln Ser His Leu Tyr Gly Pro Gly Glu Thr Ala Arg Leu 
            340                 345                 350         


Asp Cys Gln Val Gln Gly Arg Pro Gln Pro Glu Val Thr Trp Arg Ile 
        355                 360                 365             


Asn Gly Ile Pro Val Glu Glu Leu Ala Lys Asp Gln Lys Tyr Arg Ile 
    370                 375                 380                 


Gln Arg Gly Ala Leu Ile Leu Ser Asn Val Gln Pro Ser Asp Thr Met 
385                 390                 395                 400 


Val Thr Gln Cys Glu Ala Arg Asn Arg His Gly Leu Leu Leu Ala Asn 
                405                 410                 415     


Ala Tyr Ile Tyr Val Val Gln Leu Pro Ala Lys Ile Leu Thr Ala Asp 
            420                 425                 430         


Asn Gln Thr Tyr Met Ala Val Gln Gly Ser Thr Ala Tyr Leu Leu Cys 
        435                 440                 445             


Lys Ala Phe Gly Ala Pro Val Pro Ser Val Gln Trp Leu Asp Glu Asp 
    450                 455                 460                 


Gly Thr Thr Val Leu Gln Asp Glu Arg Phe Phe Pro Tyr Ala Asn Gly 
465                 470                 475                 480 


Thr Leu Gly Ile Arg Asp Leu Gln Ala Asn Asp Thr Gly Arg Tyr Phe 
                485                 490                 495     


Cys Leu Ala Ala Asn Asp Gln Asn Asn Val Thr Ile Met Ala Asn Leu 
            500                 505                 510         


Lys Val Lys Asp Ala Thr Gln Ile Thr Gln Gly Pro Arg Ser Thr Ile 
        515                 520                 525             


Glu Lys Lys Gly Ser Arg Val Thr Phe Thr Cys Gln Ala Ser Phe Asp 
    530                 535                 540                 


Pro Ser Leu Gln Pro Ser Ile Thr Trp Arg Gly Asp Gly Arg Asp Leu 
545                 550                 555                 560 


Gln Glu Leu Gly Asp Ser Asp Lys Tyr Phe Ile Glu Asp Gly Arg Leu 
                565                 570                 575     


Val Ile His Ser Leu Asp Tyr Ser Asp Gln Gly Asn Tyr Ser Cys Val 
            580                 585                 590         


Ala Ser Thr Glu Leu Asp Val Val Glu Ser Arg Ala Gln Leu Leu Val 
        595                 600                 605             


Val Gly Ser Pro Gly Pro Val Pro Arg Leu Val Leu Ser Asp Leu His 
    610                 615                 620                 


Leu Leu Thr Gln Ser Gln Val Arg Val Ser Trp Ser Pro Ala Glu Asp 
625                 630                 635                 640 


His Asn Ala Pro Ile Glu Lys Tyr Asp Ile Glu Phe Glu Asp Lys Glu 
                645                 650                 655     


Met Ala Pro Glu Lys Trp Tyr Ser Leu Gly Lys Val Pro Gly Asn Gln 
            660                 665                 670         


Thr Ser Thr Thr Leu Lys Leu Ser Pro Tyr Val His Tyr Thr Phe Arg 
        675                 680                 685             


Val Thr Ala Ile Asn Lys Tyr Gly Pro Gly Glu Pro Ser Pro Val Ser 
    690                 695                 700                 


Glu Thr Val Val Thr Pro Glu Ala Ala Pro Glu Lys Asn Pro Val Asp 
705                 710                 715                 720 


Val Lys Gly Glu Gly Asn Glu Thr Thr Asn Met Val Ile Thr Trp Lys 
                725                 730                 735     


Pro Leu Arg Trp Met Asp Trp Asn Ala Pro Gln Val Gln Tyr Arg Val 
            740                 745                 750         


Gln Trp Arg Pro Gln Gly Thr Arg Gly Pro Trp Gln Glu Gln Ile Val 
        755                 760                 765             


Ser Asp Pro Phe Leu Val Val Ser Asn Thr Ser Thr Phe Val Pro Tyr 
    770                 775                 780                 


Glu Ile Lys Val Gln Ala Val Asn Ser Gln Gly Lys Gly Pro Glu Pro 
785                 790                 795                 800 


Gln Val Thr Ile Gly Tyr Ser Gly Glu Asp Tyr Pro Gln Ala Ile Pro 
                805                 810                 815     


Glu Leu Glu Gly Ile Glu Ile Leu Asn Ser Ser Ala Val Leu Val Lys 
            820                 825                 830         


Trp Arg Pro Val Asp Leu Ala Gln Val Lys Gly His Leu Arg Gly Tyr 
        835                 840                 845             


Asn Val Thr Tyr Trp Arg Glu Gly Ser Gln Arg Lys His Ser Lys Arg 
    850                 855                 860                 


His Ile His Lys Asp His Val Val Val Pro Ala Asn Thr Thr Ser Val 
865                 870                 875                 880 


Ile Leu Ser Gly Leu Arg Pro Tyr Ser Ser Tyr His Leu Glu Val Gln 
                885                 890                 895     


Ala Phe Asn Gly Arg Gly Ser Gly Pro Ala Ser Glu Phe Thr Phe Ser 
            900                 905                 910         


Thr Pro Glu Gly Val Pro Gly His Pro Glu Ala Leu His Leu Glu Cys 
        915                 920                 925             


Gln Ser Asn Thr Ser Leu Leu Leu Arg Trp Gln Pro Pro Leu Ser His 
    930                 935                 940                 


Asn Gly Val Leu Thr Gly Tyr Val Leu Ser Tyr His Pro Leu Asp Glu 
945                 950                 955                 960 


Gly Gly Lys Gly Gln Leu Ser Phe Asn Leu Arg Asp Pro Glu Leu Arg 
                965                 970                 975     


Thr His Asn Leu Thr Asp Leu Ser Pro His Leu Arg Tyr Arg Phe Gln 
            980                 985                 990         


Leu Gln Ala Thr Thr Lys Glu Gly  Pro Gly Glu Ala Ile  Val Arg Glu 
        995                 1000                 1005             


Gly Gly  Thr Met Ala Leu Ser  Gly Ile Ser Asp Phe  Gly Asn Ile 
    1010                 1015                 1020             


Ser Ala  Thr Ala Gly Glu Asn  Tyr Ser Val Val Ser  Trp Val Pro 
    1025                 1030                 1035             


Lys Glu  Gly Gln Cys Asn Phe  Arg Phe His Ile Leu  Phe Lys Ala 
    1040                 1045                 1050             


Leu Gly  Glu Glu Lys Gly Gly  Ala Ser Leu Ser Pro  Gln Tyr Val 
    1055                 1060                 1065             


Ser Tyr  Asn Gln Ser Ser Tyr  Thr Gln Trp Asp Leu  Gln Pro Asp 
    1070                 1075                 1080             


Thr Asp  Tyr Glu Ile His Leu  Phe Lys Glu Arg Met  Phe Arg His 
    1085                 1090                 1095             


Gln Met  Ala Val Lys Thr Asn  Gly Thr Gly Arg Val  Arg Leu Pro 
    1100                 1105                 1110             


Pro Ala  Gly Phe Ala Thr Glu  Gly Trp Phe Ile Gly  Phe Val Ser 
    1115                 1120                 1125             


Ala Ile  Ile Leu Leu Leu Leu  Val Leu Leu Ile Leu  Cys Phe Ile 
    1130                 1135                 1140             


Lys Arg  Ser Lys Gly Gly Lys  Tyr Ser Val Lys Asp  Lys Glu Asp 
    1145                 1150                 1155             


Thr Gln  Val Asp Ser Glu Ala  Arg Pro Met Lys Asp  Glu Thr Phe 
    1160                 1165                 1170             


Gly Glu  Tyr Ser Asp Asn Glu  Glu Lys Ala Phe Gly  Ser Ser Gln 
    1175                 1180                 1185             


Pro Ser  Leu Asn Gly Asp Ile  Lys Pro Leu Gly Ser  Asp Asp Ser 
    1190                 1195                 1200             


Leu Ala  Asp Tyr Gly Gly Ser  Val Asp Val Gln Phe  Asn Glu Asp 
    1205                 1210                 1215             


Gly Ser  Phe Ile Gly Gln Tyr  Ser Gly Lys Lys Glu  Lys Glu Ala 
    1220                 1225                 1230             


Ala Gly  Gly Asn Asp Ser Ser  Gly Ala Thr Ser Pro  Ile Asn Pro 
    1235                 1240                 1245             


Ala Val  Ala Leu Glu 
    1250             


<210>  7620
<211>  1257
<212>  PRT
<213>  Homo Sapiens

<400>  7620

Met Val Val Ala Leu Arg Tyr Val Trp Pro Leu Leu Leu Cys Ser Pro 
1               5                   10                  15      


Cys Leu Leu Ile Gln Ile Pro Glu Glu Tyr Glu Gly His His Val Met 
            20                  25                  30          


Glu Pro Pro Val Ile Thr Glu Gln Ser Pro Arg Arg Leu Val Val Phe 
        35                  40                  45              


Pro Thr Asp Asp Ile Ser Leu Lys Cys Glu Ala Ser Gly Lys Pro Glu 
    50                  55                  60                  


Val Gln Phe Arg Trp Thr Arg Asp Gly Val His Phe Lys Pro Lys Glu 
65                  70                  75                  80  


Glu Leu Gly Val Thr Val Tyr Gln Ser Pro His Ser Gly Ser Phe Thr 
                85                  90                  95      


Ile Thr Gly Asn Asn Ser Asn Phe Ala Gln Arg Phe Gln Gly Ile Tyr 
            100                 105                 110         


Arg Cys Phe Ala Ser Asn Lys Leu Gly Thr Ala Met Ser His Glu Ile 
        115                 120                 125             


Arg Leu Met Ala Glu Gly Ala Pro Lys Trp Pro Lys Glu Thr Val Lys 
    130                 135                 140                 


Pro Val Glu Val Glu Glu Gly Glu Ser Val Val Leu Pro Cys Asn Pro 
145                 150                 155                 160 


Pro Pro Ser Ala Glu Pro Leu Arg Ile Tyr Trp Met Asn Ser Lys Ile 
                165                 170                 175     


Leu His Ile Lys Gln Asp Glu Arg Val Thr Met Gly Gln Asn Gly Asn 
            180                 185                 190         


Leu Tyr Phe Ala Asn Val Leu Thr Ser Asp Asn His Ser Asp Tyr Ile 
        195                 200                 205             


Cys His Ala His Phe Pro Gly Thr Arg Thr Ile Ile Gln Lys Glu Pro 
    210                 215                 220                 


Ile Asp Leu Arg Val Lys Ala Thr Asn Ser Met Ile Asp Arg Lys Pro 
225                 230                 235                 240 


Arg Leu Leu Phe Pro Thr Asn Ser Ser Ser His Leu Val Ala Leu Gln 
                245                 250                 255     


Gly Gln Pro Leu Val Leu Glu Cys Ile Ala Glu Gly Phe Pro Thr Pro 
            260                 265                 270         


Thr Ile Lys Trp Leu Arg Pro Ser Gly Pro Met Pro Ala Asp Arg Val 
        275                 280                 285             


Thr Tyr Gln Asn His Asn Lys Thr Leu Gln Leu Leu Lys Val Gly Glu 
    290                 295                 300                 


Glu Asp Asp Gly Glu Tyr Arg Cys Leu Ala Glu Asn Ser Leu Gly Ser 
305                 310                 315                 320 


Ala Arg His Ala Tyr Tyr Val Thr Val Glu Ala Ala Pro Tyr Trp Leu 
                325                 330                 335     


His Lys Pro Gln Ser His Leu Tyr Gly Pro Gly Glu Thr Ala Arg Leu 
            340                 345                 350         


Asp Cys Gln Val Gln Gly Arg Pro Gln Pro Glu Val Thr Trp Arg Ile 
        355                 360                 365             


Asn Gly Ile Pro Val Glu Glu Leu Ala Lys Asp Gln Lys Tyr Arg Ile 
    370                 375                 380                 


Gln Arg Gly Ala Leu Ile Leu Ser Asn Val Gln Pro Ser Asp Thr Met 
385                 390                 395                 400 


Val Thr Gln Cys Glu Ala Arg Asn Arg His Gly Leu Leu Leu Ala Asn 
                405                 410                 415     


Ala Tyr Ile Tyr Val Val Gln Leu Pro Ala Lys Ile Leu Thr Ala Asp 
            420                 425                 430         


Asn Gln Thr Tyr Met Ala Val Gln Gly Ser Thr Ala Tyr Leu Leu Cys 
        435                 440                 445             


Lys Ala Phe Gly Ala Pro Val Pro Ser Val Gln Trp Leu Asp Glu Asp 
    450                 455                 460                 


Gly Thr Thr Val Leu Gln Asp Glu Arg Phe Phe Pro Tyr Ala Asn Gly 
465                 470                 475                 480 


Thr Leu Gly Ile Arg Asp Leu Gln Ala Asn Asp Thr Gly Arg Tyr Phe 
                485                 490                 495     


Cys Leu Ala Ala Asn Asp Gln Asn Asn Val Thr Ile Met Ala Asn Leu 
            500                 505                 510         


Lys Val Lys Asp Ala Thr Gln Ile Thr Gln Gly Pro Arg Ser Thr Ile 
        515                 520                 525             


Glu Lys Lys Gly Ser Arg Val Thr Phe Thr Cys Gln Ala Ser Phe Asp 
    530                 535                 540                 


Pro Ser Leu Gln Pro Ser Ile Thr Trp Arg Gly Asp Gly Arg Asp Leu 
545                 550                 555                 560 


Gln Glu Leu Gly Asp Ser Asp Lys Tyr Phe Ile Glu Asp Gly Arg Leu 
                565                 570                 575     


Val Ile His Ser Leu Asp Tyr Ser Asp Gln Gly Asn Tyr Ser Cys Val 
            580                 585                 590         


Ala Ser Thr Glu Leu Asp Val Val Glu Ser Arg Ala Gln Leu Leu Val 
        595                 600                 605             


Val Gly Ser Pro Gly Pro Val Pro Arg Leu Val Leu Ser Asp Leu His 
    610                 615                 620                 


Leu Leu Thr Gln Ser Gln Val Arg Val Ser Trp Ser Pro Ala Glu Asp 
625                 630                 635                 640 


His Asn Ala Pro Ile Glu Lys Tyr Asp Ile Glu Phe Glu Asp Lys Glu 
                645                 650                 655     


Met Ala Pro Glu Lys Trp Tyr Ser Leu Gly Lys Val Pro Gly Asn Gln 
            660                 665                 670         


Thr Ser Thr Thr Leu Lys Leu Ser Pro Tyr Val His Tyr Thr Phe Arg 
        675                 680                 685             


Val Thr Ala Ile Asn Lys Tyr Gly Pro Gly Glu Pro Ser Pro Val Ser 
    690                 695                 700                 


Glu Thr Val Val Thr Pro Glu Ala Ala Pro Glu Lys Asn Pro Val Asp 
705                 710                 715                 720 


Val Lys Gly Glu Gly Asn Glu Thr Thr Asn Met Val Ile Thr Trp Lys 
                725                 730                 735     


Pro Leu Arg Trp Met Asp Trp Asn Ala Pro Gln Val Gln Tyr Arg Val 
            740                 745                 750         


Gln Trp Arg Pro Gln Gly Thr Arg Gly Pro Trp Gln Glu Gln Ile Val 
        755                 760                 765             


Ser Asp Pro Phe Leu Val Val Ser Asn Thr Ser Thr Phe Val Pro Tyr 
    770                 775                 780                 


Glu Ile Lys Val Gln Ala Val Asn Ser Gln Gly Lys Gly Pro Glu Pro 
785                 790                 795                 800 


Gln Val Thr Ile Gly Tyr Ser Gly Glu Asp Tyr Pro Gln Ala Ile Pro 
                805                 810                 815     


Glu Leu Glu Gly Ile Glu Ile Leu Asn Ser Ser Ala Val Leu Val Lys 
            820                 825                 830         


Trp Arg Pro Val Asp Leu Ala Gln Val Lys Gly His Leu Arg Gly Tyr 
        835                 840                 845             


Asn Val Thr Tyr Trp Arg Glu Gly Ser Gln Arg Lys His Ser Lys Arg 
    850                 855                 860                 


His Ile His Lys Asp His Val Val Val Pro Ala Asn Thr Thr Ser Val 
865                 870                 875                 880 


Ile Leu Ser Gly Leu Arg Pro Tyr Ser Ser Tyr His Leu Glu Val Gln 
                885                 890                 895     


Ala Phe Asn Gly Arg Gly Ser Gly Pro Ala Ser Glu Phe Thr Phe Ser 
            900                 905                 910         


Thr Pro Glu Gly Val Pro Gly His Pro Glu Ala Leu His Leu Glu Cys 
        915                 920                 925             


Gln Ser Asn Thr Ser Leu Leu Leu Arg Trp Gln Pro Pro Leu Ser His 
    930                 935                 940                 


Asn Gly Val Leu Thr Gly Tyr Val Leu Ser Tyr His Pro Leu Asp Glu 
945                 950                 955                 960 


Gly Gly Lys Gly Gln Leu Ser Phe Asn Leu Arg Asp Pro Glu Leu Arg 
                965                 970                 975     


Thr His Asn Leu Thr Asp Leu Ser Pro His Leu Arg Tyr Arg Phe Gln 
            980                 985                 990         


Leu Gln Ala Thr Thr Lys Glu Gly  Pro Gly Glu Ala Ile  Val Arg Glu 
        995                 1000                 1005             


Gly Gly  Thr Met Ala Leu Ser  Gly Ile Ser Asp Phe  Gly Asn Ile 
    1010                 1015                 1020             


Ser Ala  Thr Ala Gly Glu Asn  Tyr Ser Val Val Ser  Trp Val Pro 
    1025                 1030                 1035             


Lys Glu  Gly Gln Cys Asn Phe  Arg Phe His Ile Leu  Phe Lys Ala 
    1040                 1045                 1050             


Leu Gly  Glu Glu Lys Gly Gly  Ala Ser Leu Ser Pro  Gln Tyr Val 
    1055                 1060                 1065             


Ser Tyr  Asn Gln Ser Ser Tyr  Thr Gln Trp Asp Leu  Gln Pro Asp 
    1070                 1075                 1080             


Thr Asp  Tyr Glu Ile His Leu  Phe Lys Glu Arg Met  Phe Arg His 
    1085                 1090                 1095             


Gln Met  Ala Val Lys Thr Asn  Gly Thr Gly Arg Val  Arg Leu Pro 
    1100                 1105                 1110             


Pro Ala  Gly Phe Ala Thr Glu  Gly Trp Phe Ile Gly  Phe Val Ser 
    1115                 1120                 1125             


Ala Ile  Ile Leu Leu Leu Leu  Val Leu Leu Ile Leu  Cys Phe Ile 
    1130                 1135                 1140             


Lys Arg  Ser Lys Gly Gly Lys  Tyr Ser Val Lys Asp  Lys Glu Asp 
    1145                 1150                 1155             


Thr Gln  Val Asp Ser Glu Ala  Arg Pro Met Lys Asp  Glu Thr Phe 
    1160                 1165                 1170             


Gly Glu  Tyr Arg Ser Leu Glu  Ser Asp Asn Glu Glu  Lys Ala Phe 
    1175                 1180                 1185             


Gly Ser  Ser Gln Pro Ser Leu  Asn Gly Asp Ile Lys  Pro Leu Gly 
    1190                 1195                 1200             


Ser Asp  Asp Ser Leu Ala Asp  Tyr Gly Gly Ser Val  Asp Val Gln 
    1205                 1210                 1215             


Phe Asn  Glu Asp Gly Ser Phe  Ile Gly Gln Tyr Ser  Gly Lys Lys 
    1220                 1225                 1230             


Glu Lys  Glu Ala Ala Gly Gly  Asn Asp Ser Ser Gly  Ala Thr Ser 
    1235                 1240                 1245             


Pro Ile  Asn Pro Ala Val Ala  Leu Glu 
    1250                 1255         


<210>  7621
<211>  190
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7621

Xaa Asp Pro Ser Leu Gln Pro Ser Ile Thr Trp Arg Gly Asp Gly Arg 
1               5                   10                  15      


Asp Leu Gln Glu Leu Gly Asp Ser Asp Lys Tyr Phe Ile Glu Asp Gly 
            20                  25                  30          


Arg Leu Val Ile His Ser Leu Asp Tyr Ser Asp Gln Gly Asn Tyr Ser 
        35                  40                  45              


Cys Val Ala Ser Thr Glu Leu Asp Val Val Glu Ser Arg Ala Gln Leu 
    50                  55                  60                  


Leu Val Val Glu Tyr Asp Ile Glu Phe Glu Asp Lys Glu Met Ala Pro 
65                  70                  75                  80  


Glu Lys Trp Tyr Ser Leu Gly Lys Val Pro Gly Asn Gln Thr Ser Thr 
                85                  90                  95      


Thr Leu Lys Leu Ser Pro Tyr Val His Tyr Thr Phe Arg Val Thr Ala 
            100                 105                 110         


Ile Asn Lys Tyr Gly Pro Gly Glu Pro Ser Pro Val Ser Glu Thr Val 
        115                 120                 125             


Val Thr Pro Glu Ala Ala Pro Glu Lys Asn Pro Val Asp Val Lys Gly 
    130                 135                 140                 


Glu Gly Asn Glu Thr Thr Asn Met Val Ile Thr Trp Lys Pro Leu Arg 
145                 150                 155                 160 


Trp Met Asp Trp Asn Ala Pro Gln Val Gln Tyr Arg Val Gln Trp Arg 
                165                 170                 175     


Pro Gln Gly Thr Arg Gly Pro Trp Gln Glu Gln Ile Val Ser 
            180                 185                 190 


<210>  7622
<211>  232
<212>  PRT
<213>  Homo Sapiens

<400>  7622

Glu Thr Pro Ser Ser Glu Pro Met Glu Glu Glu Glu Asp Asp Asp Leu 
1               5                   10                  15      


Glu Leu Phe Gly Gly Tyr Asp Ser Phe Arg Ser Tyr Asn Ser Ser Val 
            20                  25                  30          


Gly Ser Glu Ser Ser Ser Tyr Leu Glu Glu Ser Ser Glu Ala Glu Asn 
        35                  40                  45              


Glu Asp Arg Glu Ala Gly Glu Leu Pro Thr Ser Pro Leu His Leu Leu 
    50                  55                  60                  


Ser Pro Gly Thr Pro Arg Ser Leu Asp Gly Ser Gly Ser Glu Pro Ala 
65                  70                  75                  80  


Val Cys Glu Met Cys Gly Ile Val Gly Thr Arg Glu Ala Phe Phe Ser 
                85                  90                  95      


Lys Thr Lys Arg Phe Cys Ser Val Ser Cys Ser Arg Ser Tyr Ser Ser 
            100                 105                 110         


Asn Ser Lys Lys Ala Ser Ile Leu Ala Arg Leu Gln Gly Lys Pro Pro 
        115                 120                 125             


Thr Lys Lys Ala Lys Val Leu His Lys Ala Ala Trp Ser Ala Lys Ile 
    130                 135                 140                 


Gly Ala Phe Leu His Ser Gln Gly Thr Gly Gln Leu Ala Asp Gly Thr 
145                 150                 155                 160 


Pro Thr Gly Gln Asp Ala Leu Val Leu Gly Phe Asp Trp Gly Lys Phe 
                165                 170                 175     


Leu Lys Asp His Ser Tyr Lys Ala Ala Pro Val Ser Cys Phe Lys His 
            180                 185                 190         


Gly Ile Gly Cys Cys Phe Gly Met Lys Ala Leu Lys Met Thr Pro Ala 
        195                 200                 205             


Met Thr Ser Gly Ala Thr Trp Glu Gln Trp Met Ser Thr Pro Leu Ala 
    210                 215                 220                 


Gly Val Pro Ser Thr Ala Arg Ser 
225                 230         


<210>  7623
<211>  705
<212>  PRT
<213>  Homo Sapiens

<400>  7623

Met Glu Lys Pro Arg Ser Ile Glu Glu Thr Pro Ser Ser Glu Pro Met 
1               5                   10                  15      


Glu Glu Glu Glu Asp Asp Asp Leu Glu Leu Phe Gly Gly Tyr Asp Ser 
            20                  25                  30          


Phe Arg Ser Tyr Asn Ser Ser Val Gly Ser Glu Ser Ser Ser Tyr Leu 
        35                  40                  45              


Glu Glu Ser Ser Glu Ala Glu Asn Glu Asp Arg Glu Ala Gly Glu Leu 
    50                  55                  60                  


Pro Thr Ser Pro Leu His Leu Leu Ser Pro Gly Thr Pro Arg Ser Leu 
65                  70                  75                  80  


Asp Gly Ser Gly Ser Glu Pro Ala Val Cys Glu Met Cys Gly Ile Val 
                85                  90                  95      


Gly Thr Arg Glu Ala Phe Phe Ser Lys Thr Lys Arg Phe Cys Ser Val 
            100                 105                 110         


Ser Cys Ser Arg Ser Tyr Ser Ser Asn Ser Lys Lys Ala Ser Ile Leu 
        115                 120                 125             


Ala Arg Leu Gln Gly Lys Pro Pro Thr Lys Lys Ala Lys Val Leu His 
    130                 135                 140                 


Lys Ala Ala Trp Ser Ala Lys Ile Gly Ala Phe Leu His Ser Gln Gly 
145                 150                 155                 160 


Thr Gly Gln Leu Ala Asp Gly Thr Pro Thr Gly Gln Asp Ala Leu Val 
                165                 170                 175     


Leu Gly Phe Asp Trp Gly Lys Phe Leu Lys Asp His Ser Tyr Lys Ala 
            180                 185                 190         


Ala Pro Val Ser Cys Phe Lys His Val Pro Leu Tyr Asp Gln Trp Glu 
        195                 200                 205             


Asp Val Met Lys Gly Met Lys Val Glu Val Leu Asn Ser Asp Ala Val 
    210                 215                 220                 


Leu Pro Ser Arg Val Tyr Trp Ile Ala Ser Val Ile Gln Thr Ala Gly 
225                 230                 235                 240 


Tyr Arg Val Leu Leu Arg Tyr Glu Gly Phe Glu Asn Asp Ala Ser His 
                245                 250                 255     


Asp Phe Trp Cys Asn Leu Gly Thr Val Asp Val His Pro Ile Gly Trp 
            260                 265                 270         


Cys Ala Ile Asn Ser Lys Ile Leu Val Pro Pro Arg Thr Ile His Ala 
        275                 280                 285             


Lys Phe Thr Asp Trp Lys Gly Tyr Leu Met Lys Arg Leu Val Gly Ser 
    290                 295                 300                 


Arg Thr Leu Pro Val Asp Phe His Ile Lys Met Val Glu Ser Met Lys 
305                 310                 315                 320 


Tyr Pro Phe Arg Gln Gly Met Arg Leu Glu Val Val Asp Lys Ser Gln 
                325                 330                 335     


Val Ser Arg Thr Arg Met Ala Val Val Asp Thr Val Ile Gly Gly Arg 
            340                 345                 350         


Leu Arg Leu Leu Tyr Glu Asp Gly Asp Ser Asp Asp Asp Phe Trp Cys 
        355                 360                 365             


His Met Trp Ser Pro Leu Ile His Pro Val Gly Trp Ser Arg Arg Val 
    370                 375                 380                 


Gly His Gly Ile Lys Met Ser Glu Arg Arg Ser Asp Met Ala His His 
385                 390                 395                 400 


Pro Thr Phe Arg Lys Ile Tyr Cys Asp Ala Val Pro Tyr Leu Phe Lys 
                405                 410                 415     


Lys Val Arg Ala Val Tyr Thr Glu Gly Gly Trp Phe Glu Glu Gly Met 
            420                 425                 430         


Lys Leu Glu Ala Ile Asp Pro Leu Asn Leu Gly Asn Ile Cys Val Ala 
        435                 440                 445             


Thr Val Cys Lys Val Leu Leu Asp Gly Tyr Leu Met Ile Cys Val Asp 
    450                 455                 460                 


Gly Gly Pro Ser Thr Asp Gly Leu Asp Trp Phe Cys Tyr His Ala Ser 
465                 470                 475                 480 


Ser His Ala Ile Phe Pro Ala Thr Phe Cys Gln Lys Asn Asp Ile Glu 
                485                 490                 495     


Leu Thr Pro Pro Lys Gly Tyr Glu Ala Gln Thr Phe Asn Trp Glu Asn 
            500                 505                 510         


Tyr Leu Glu Lys Thr Lys Ser Lys Ala Ala Pro Ser Arg Leu Phe Asn 
        515                 520                 525             


Met Asp Cys Pro Asn His Gly Phe Lys Val Gly Met Lys Leu Glu Ala 
    530                 535                 540                 


Val Asp Leu Met Glu Pro Arg Leu Ile Cys Val Ala Thr Val Lys Arg 
545                 550                 555                 560 


Val Val His Arg Leu Leu Ser Ile His Phe Asp Gly Trp Asp Ser Glu 
                565                 570                 575     


Tyr Asp Gln Trp Val Asp Cys Glu Ser Pro Asp Ile Tyr Pro Val Gly 
            580                 585                 590         


Trp Cys Glu Leu Thr Gly Tyr Gln Leu Gln Pro Pro Val Ala Ala Glu 
        595                 600                 605             


Pro Ala Thr Pro Leu Lys Ala Lys Glu Ala Thr Lys Lys Lys Lys Lys 
    610                 615                 620                 


Gln Phe Gly Lys Lys Arg Lys Arg Ile Pro Pro Thr Lys Thr Arg Pro 
625                 630                 635                 640 


Leu Arg Gln Gly Ser Lys Lys Pro Leu Leu Glu Asp Asp Pro Gln Gly 
                645                 650                 655     


Ala Arg Lys Ile Ser Ser Glu Pro Val Pro Gly Glu Ile Ile Ala Val 
            660                 665                 670         


Arg Val Lys Glu Glu His Leu Asp Val Ala Ser Pro Asp Lys Ala Ser 
        675                 680                 685             


Ser Pro Glu Leu Pro Val Ser Val Glu Asn Ile Lys Gln Glu Thr Asp 
    690                 695                 700                 


Asp 
705 


<210>  7624
<211>  614
<212>  PRT
<213>  Homo Sapiens

<400>  7624

Met Glu Lys Pro Arg Ser Ile Glu Glu Thr Pro Ser Ser Glu Pro Met 
1               5                   10                  15      


Glu Glu Glu Glu Asp Asp Asp Leu Glu Leu Phe Gly Gly Tyr Asp Ser 
            20                  25                  30          


Phe Arg Ser Tyr Asn Ser Ser Val Gly Ser Glu Ser Ser Ser Tyr Leu 
        35                  40                  45              


Glu Glu Ser Ser Glu Ala Glu Asn Glu Asp Arg Glu Ala Gly Glu Leu 
    50                  55                  60                  


Pro Thr Ser Pro Leu His Leu Leu Ser Pro Gly Thr Pro Arg Ser Leu 
65                  70                  75                  80  


Asp Gly Ser Gly Ser Glu Pro Ala Val Cys Glu Met Cys Gly Ile Val 
                85                  90                  95      


Gly Thr Arg Glu Ala Phe Phe Ser Lys Thr Lys Arg Phe Cys Ser Val 
            100                 105                 110         


Ser Cys Ser Arg Ser Tyr Ser Ser Asn Ser Lys Lys Ala Ser Ile Leu 
        115                 120                 125             


Ala Arg Leu Gln Gly Lys Pro Pro Thr Lys Lys Ala Lys Val Leu His 
    130                 135                 140                 


Lys Ala Ala Trp Ser Ala Lys Ile Gly Ala Phe Leu His Ser Gln Gly 
145                 150                 155                 160 


Thr Gly Gln Leu Ala Asp Gly Thr Pro Thr Gly Gln Asp Ala Leu Val 
                165                 170                 175     


Leu Gly Phe Asp Trp Gly Lys Phe Leu Lys Asp His Ser Tyr Lys Ala 
            180                 185                 190         


Ala Pro Val Ser Cys Phe Lys His Val Pro Leu Tyr Asp Gln Trp Glu 
        195                 200                 205             


Asp Val Met Lys Gly Met Lys Val Glu Val Leu Asn Ser Asp Ala Val 
    210                 215                 220                 


Leu Pro Ser Arg Val Tyr Trp Ile Ala Ser Val Ile Gln Thr Ala Gly 
225                 230                 235                 240 


Tyr Arg Val Leu Leu Arg Tyr Glu Gly Phe Glu Asn Asp Ala Ser His 
                245                 250                 255     


Asp Phe Trp Cys Asn Leu Gly Thr Val Asp Val His Pro Ile Gly Trp 
            260                 265                 270         


Cys Ala Ile Asn Ser Lys Ile Leu Val Pro Pro Arg Thr Ile His Ala 
        275                 280                 285             


Lys Phe Thr Asp Trp Lys Gly Tyr Leu Met Lys Arg Leu Val Gly Ser 
    290                 295                 300                 


Arg Thr Leu Pro Val Asp Phe His Ile Lys Met Val Glu Ser Met Lys 
305                 310                 315                 320 


Tyr Pro Phe Arg Gln Gly Met Arg Leu Glu Val Val Asp Lys Ser Gln 
                325                 330                 335     


Val Ser Arg Thr Arg Met Ala Val Val Asp Thr Val Ile Gly Gly Arg 
            340                 345                 350         


Leu Arg Leu Leu Tyr Glu Asp Gly Asp Ser Asp Asp Asp Phe Trp Cys 
        355                 360                 365             


His Met Trp Ser Pro Leu Ile His Pro Val Gly Trp Ser Arg Arg Val 
    370                 375                 380                 


Gly His Gly Ile Lys Met Ser Glu Arg Arg Ser Asp Met Ala His His 
385                 390                 395                 400 


Pro Thr Phe Arg Lys Ile Tyr Cys Asp Ala Val Pro Tyr Leu Phe Lys 
                405                 410                 415     


Lys Val Arg Ala Val Tyr Thr Glu Gly Gly Trp Phe Glu Glu Gly Met 
            420                 425                 430         


Lys Leu Glu Ala Ile Asp Pro Leu Asn Leu Gly Asn Ile Cys Val Ala 
        435                 440                 445             


Thr Val Cys Lys Val Leu Leu Asp Gly Tyr Leu Met Ile Cys Val Asp 
    450                 455                 460                 


Gly Gly Pro Ser Thr Asp Gly Leu Asp Trp Phe Cys Tyr His Ala Ser 
465                 470                 475                 480 


Ser His Ala Ile Phe Pro Ala Thr Phe Cys Gln Lys Asn Asp Ile Glu 
                485                 490                 495     


Leu Thr Pro Pro Lys Gly Tyr Glu Ala Gln Thr Phe Asn Trp Glu Asn 
            500                 505                 510         


Tyr Leu Glu Lys Thr Lys Ser Lys Ala Ala Pro Ser Arg Leu Phe Asn 
        515                 520                 525             


Met Asp Cys Pro Asn His Gly Phe Lys Val Gly Met Lys Leu Glu Ala 
    530                 535                 540                 


Val Asp Leu Met Glu Pro Arg Leu Ile Cys Val Ala Thr Val Lys Arg 
545                 550                 555                 560 


Val Val His Arg Leu Leu Ser Ile His Phe Asp Gly Trp Asp Ser Glu 
                565                 570                 575     


Tyr Asp Gln Trp Val Asp Cys Glu Ser Pro Asp Ile Tyr Pro Val Gly 
            580                 585                 590         


Trp Cys Glu Leu Thr Gly Tyr Gln Leu Gln Pro Pro Val Ala Ala Gly 
        595                 600                 605             


Lys Leu Pro Arg Ser Leu 
    610                 


<210>  7625
<211>  40
<212>  PRT
<213>  Homo Sapiens

<400>  7625

Met Glu Lys Pro Arg Ser Ile Glu Arg Trp Gly Val Ala Val Leu Pro 
1               5                   10                  15      


Arg Leu Val Ser Asn Ser Trp Val Gln Ala Ile His Leu Pro Gln Pro 
            20                  25                  30          


Pro Lys Val Leu Gly Leu Gln Met 
        35                  40  


<210>  7626
<211>  288
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7626

Xaa Arg Pro His Leu Gln Asn Gln Trp Arg Lys Arg Lys Met Thr Thr 
1               5                   10                  15      


Trp Ser Cys Leu Val Ala Met Ile Val Ser Gly Val Ile Thr Ala Val 
            20                  25                  30          


Trp Ala Val Arg Ala Ala Pro Ile Trp Arg Ser Gln Val Lys Gln Lys 
        35                  40                  45              


Met Arg Ile Gly Lys Gln Gly Asn Cys Arg Pro Pro Arg Cys Ile Cys 
    50                  55                  60                  


Ser Ala Leu Gly Leu Leu Ala Pro Trp Met Ala Val Val Leu Ser Gln 
65                  70                  75                  80  


Gly Lys Pro Pro Thr Lys Lys Ala Lys Val Leu His Lys Ala Ala Trp 
                85                  90                  95      


Ser Ala Lys Ile Gly Ala Phe Leu His Ser Gln Gly Thr Gly Gln Leu 
            100                 105                 110         


Ala Asp Gly Thr Pro Thr Gly Gln Asp Ala Leu Val Leu Gly Phe Asp 
        115                 120                 125             


Trp Gly Lys Phe Leu Lys Asp His Ser Tyr Lys Ala Ala Pro Val Ser 
    130                 135                 140                 


Cys Phe Lys His Val Pro Leu Tyr Asp Gln Trp Glu Asp Val Met Lys 
145                 150                 155                 160 


Gly Met Lys Val Glu Val Leu Asn Ser Asp Ala Val Leu Pro Ser Arg 
                165                 170                 175     


Val Tyr Trp Ile Ala Ser Val Ile Gln Thr Ala Gly Tyr Arg Val Leu 
            180                 185                 190         


Leu Arg Tyr Glu Gly Phe Glu Asn Asp Ala Ser His Asp Phe Trp Cys 
        195                 200                 205             


Asn Leu Gly Thr Val Asp Val His Pro Ile Gly Trp Cys Ala Ile Asn 
    210                 215                 220                 


Ser Lys Ile Leu Val Pro Pro Arg Thr Ile His Ala Lys Phe Thr Asp 
225                 230                 235                 240 


Trp Lys Gly Tyr Leu Met Lys Arg Leu Val Gly Ser Arg Thr Leu Pro 
                245                 250                 255     


Val Asp Phe His Ile Lys Val Gly Ser Glu Pro Leu Thr Asp Val Pro 
            260                 265                 270         


Pro Ser Ala Leu Pro Phe Phe Cys Ile Leu His Ala Thr His Trp Ser 
        275                 280                 285             


<210>  7627
<211>  127
<212>  PRT
<213>  Homo Sapiens

<400>  7627

Met Lys Phe Thr Thr Leu Leu Phe Leu Ala Ala Val Ala Gly Ala Leu 
1               5                   10                  15      


Val Tyr Ala Glu Asp Ala Ser Ser Asp Ser Thr Gly Ala Asp Pro Ala 
            20                  25                  30          


Gln Glu Ala Gly Thr Ser Lys Pro Asn Glu Glu Ile Ser Gly Pro Ala 
        35                  40                  45              


Glu Pro Ala Ser Pro Pro Glu Thr Thr Thr Thr Ala Gln Glu Thr Ser 
    50                  55                  60                  


Ala Ala Ala Val Gln Gly Thr Ala Lys Val Thr Ser Ser Arg Gln Glu 
65                  70                  75                  80  


Leu Asn Pro Leu Lys Gln Ala Leu Ala Lys Ala Gly Lys Gly Met His 
                85                  90                  95      


Gly Gly Val Pro Gly Gly Lys Gln Phe Ile Glu Asn Gly Ser Glu Phe 
            100                 105                 110         


Ala Gln Lys Leu Leu Lys Lys Phe Ser Leu Leu Lys Pro Trp Ala 
        115                 120                 125         


<210>  7628
<211>  138
<212>  PRT
<213>  Homo Sapiens

<400>  7628

Met Lys Phe Thr Thr Leu Leu Phe Leu Ala Ala Val Ala Gly Ala Leu 
1               5                   10                  15      


Val Tyr Ala Glu Asp Ala Ser Ser Asp Ser Thr Gly Ala Asp Pro Ala 
            20                  25                  30          


Gln Glu Ala Gly Thr Ser Lys Pro Asn Glu Glu Ile Ser Gly Pro Ala 
        35                  40                  45              


Glu Pro Ala Ser Pro Pro Glu Thr Thr Thr Thr Ala Gln Glu Thr Ser 
    50                  55                  60                  


Ala Ala Ala Val Gln Gly Thr Ala Lys Val Thr Ser Ser Arg Gln Glu 
65                  70                  75                  80  


Leu Asn Pro Leu Lys Ser Ile Val Glu Lys Ser Ile Leu Leu Thr Glu 
                85                  90                  95      


Gln Ala Leu Ala Lys Ala Gly Lys Gly Met His Gly Gly Val Pro Gly 
            100                 105                 110         


Gly Lys Gln Phe Ile Glu Asn Gly Ser Glu Phe Ala Gln Lys Leu Leu 
        115                 120                 125             


Lys Lys Phe Ser Leu Leu Lys Pro Trp Ala 
    130                 135             


<210>  7629
<211>  85
<212>  PRT
<213>  Homo Sapiens

<400>  7629

Pro Ala Gln Glu Ala Gly Thr Ser Lys Pro Asn Glu Glu Ile Ser Gly 
1               5                   10                  15      


Pro Ala Glu Pro Ala Ser Pro Pro Glu Thr Thr Thr Thr Ala Gln Glu 
            20                  25                  30          


Thr Ser Ala Ala Ala Val Gln Gly Thr Ala Lys Val Thr Ser Ser Arg 
        35                  40                  45              


Gln Glu Leu Asn Pro Leu Lys Gln Ala Leu Ala Lys Ala Gly Lys Gly 
    50                  55                  60                  


Met His Gly Gly Val Pro Gly Gly Lys Gln Phe Ile Glu Ser Glu Cys 
65                  70                  75                  80  


Ile Pro Arg Trp Lys 
                85  


<210>  7630
<211>  126
<212>  PRT
<213>  Homo Sapiens

<400>  7630

Met Arg Ile Ala Ser Ile Ser Lys Ser Leu Thr Met Val Ala Leu Ala 
1               5                   10                  15      


Lys Leu Trp Glu Ala Gly Lys Leu Asp Leu Asp Ile Pro Val Gln His 
            20                  25                  30          


Tyr Val Pro Glu Phe Pro Glu Lys Glu Tyr Glu Gly Glu Lys Val Ser 
        35                  40                  45              


Val Thr Thr Arg Leu Leu Ile Ser His Leu Ser Gly Ile Arg His Tyr 
    50                  55                  60                  


Glu Lys Asp Ile Lys Lys Val Lys Glu Glu Lys Ala Tyr Lys Ala Leu 
65                  70                  75                  80  


Lys Met Met Lys Glu Asn Val Ala Phe Glu Gln Glu Lys Glu Gly Lys 
                85                  90                  95      


Ser Asn Glu Lys Asn Asp Phe Thr Lys Phe Lys Thr Glu Gln Glu Asn 
            100                 105                 110         


Glu Ala Lys Cys Arg Asn Ser Lys Pro Gly Lys Lys Lys Asn 
        115                 120                 125     


<210>  7631
<211>  547
<212>  PRT
<213>  Homo Sapiens

<400>  7631

Met Tyr Arg Leu Met Ser Ala Val Thr Ala Arg Ala Ala Ala Pro Gly 
1               5                   10                  15      


Gly Leu Ala Ser Ser Cys Gly Arg Arg Gly Val His Gln Arg Ala Gly 
            20                  25                  30          


Leu Pro Pro Leu Gly His Gly Trp Val Gly Gly Leu Gly Leu Gly Leu 
        35                  40                  45              


Gly Leu Ala Leu Gly Val Lys Leu Ala Gly Gly Leu Arg Gly Ala Ala 
    50                  55                  60                  


Pro Ala Gln Ser Pro Ala Ala Pro Asp Pro Glu Ala Ser Pro Leu Ala 
65                  70                  75                  80  


Glu Pro Pro Gln Glu Gln Ser Leu Ala Pro Trp Ser Pro Gln Thr Pro 
                85                  90                  95      


Ala Pro Pro Cys Ser Arg Cys Phe Ala Arg Ala Ile Glu Ser Ser Arg 
            100                 105                 110         


Asp Leu Leu His Arg Ile Lys Asp Glu Val Gly Ala Pro Gly Ile Val 
        115                 120                 125             


Val Gly Val Ser Val Asp Gly Lys Glu Val Trp Ser Glu Gly Leu Gly 
    130                 135                 140                 


Tyr Ala Asp Val Glu Asn Arg Val Pro Cys Lys Pro Glu Thr Val Met 
145                 150                 155                 160 


Arg Ile Ala Ser Ile Ser Lys Ser Leu Thr Met Val Ala Leu Ala Lys 
                165                 170                 175     


Leu Trp Glu Ala Gly Lys Leu Asp Leu Asp Ile Pro Val Gln His Tyr 
            180                 185                 190         


Val Pro Glu Phe Pro Glu Lys Glu Tyr Glu Gly Glu Lys Val Ser Val 
        195                 200                 205             


Thr Thr Arg Leu Leu Ile Ser His Leu Ser Gly Ile Arg His Tyr Glu 
    210                 215                 220                 


Lys Asp Ile Lys Lys Val Lys Glu Glu Lys Ala Tyr Lys Ala Leu Lys 
225                 230                 235                 240 


Met Met Lys Glu Asn Val Ala Phe Glu Gln Glu Lys Glu Gly Lys Ser 
                245                 250                 255     


Asn Glu Lys Asn Asp Phe Thr Lys Phe Lys Thr Glu Gln Glu Asn Glu 
            260                 265                 270         


Ala Lys Cys Arg Asn Ser Lys Pro Gly Lys Lys Lys Asn Asp Phe Glu 
        275                 280                 285             


Gln Gly Glu Leu Tyr Leu Arg Glu Lys Phe Glu Asn Ser Ile Glu Ser 
    290                 295                 300                 


Leu Arg Leu Phe Lys Asn Asp Pro Leu Phe Phe Lys Pro Gly Ser Gln 
305                 310                 315                 320 


Phe Leu Tyr Ser Thr Phe Gly Tyr Thr Leu Leu Ala Ala Ile Val Glu 
                325                 330                 335     


Arg Ala Ser Gly Cys Lys Tyr Leu Asp Tyr Met Gln Lys Ile Phe His 
            340                 345                 350         


Asp Leu Asp Met Leu Thr Thr Val Gln Glu Glu Asn Glu Pro Val Ile 
        355                 360                 365             


Tyr Asn Arg Ala Arg Phe Tyr Val Tyr Asn Lys Lys Lys Arg Leu Val 
    370                 375                 380                 


Asn Thr Pro Tyr Val Asp Asn Ser Tyr Lys Trp Ala Gly Gly Gly Phe 
385                 390                 395                 400 


Leu Ser Thr Val Gly Asp Leu Leu Lys Phe Gly Asn Ala Met Leu Tyr 
                405                 410                 415     


Gly Tyr Gln Val Gly Leu Phe Lys Asn Ser Asn Glu Asn Leu Leu Pro 
            420                 425                 430         


Gly Tyr Leu Lys Pro Glu Thr Met Val Met Met Trp Thr Pro Val Pro 
        435                 440                 445             


Asn Thr Glu Met Ser Trp Asp Lys Glu Gly Lys Tyr Ala Met Ala Trp 
    450                 455                 460                 


Gly Val Val Glu Arg Lys Gln Thr Tyr Gly Ser Cys Arg Lys Gln Arg 
465                 470                 475                 480 


His Tyr Ala Ser His Thr Gly Gly Ala Val Gly Ala Ser Ser Val Leu 
                485                 490                 495     


Leu Val Leu Pro Glu Glu Leu Asp Thr Glu Thr Ile Asn Asn Lys Val 
            500                 505                 510         


Pro Pro Arg Gly Ile Ile Val Ser Ile Ile Cys Asn Met Gln Ser Val 
        515                 520                 525             


Gly Leu Asn Ser Thr Ala Leu Lys Ile Ala Leu Glu Phe Asp Lys Asp 
    530                 535                 540                 


Arg Ser Asp 
545         


<210>  7632
<211>  373
<212>  PRT
<213>  Homo Sapiens

<400>  7632

Met Tyr Arg Leu Met Ser Ala Val Thr Ala Arg Ala Ala Ala Pro Gly 
1               5                   10                  15      


Gly Leu Ala Ser Ser Cys Gly Arg Arg Gly Val His Gln Arg Ala Gly 
            20                  25                  30          


Leu Pro Pro Leu Gly His Gly Trp Val Gly Gly Leu Gly Leu Gly Leu 
        35                  40                  45              


Gly Leu Ala Leu Gly Val Lys Leu Ala Gly Gly Leu Arg Gly Ala Ala 
    50                  55                  60                  


Pro Ala Gln Ser Pro Ala Ala Pro Asp Pro Glu Ala Ser Pro Leu Ala 
65                  70                  75                  80  


Glu Pro Pro Gln Glu Gln Ser Leu Ala Pro Trp Ser Pro Gln Thr Pro 
                85                  90                  95      


Ala Pro Pro Cys Ser Arg Cys Phe Ala Arg Ala Ile Glu Ser Ser Arg 
            100                 105                 110         


Asp Leu Leu His Arg Ile Lys Asp Glu Val Gly Ala Pro Gly Ile Val 
        115                 120                 125             


Val Gly Val Ser Val Asp Gly Lys Glu Val Trp Ser Glu Gly Leu Gly 
    130                 135                 140                 


Tyr Ala Asp Val Glu Asn Arg Val Pro Cys Lys Pro Glu Thr Val Met 
145                 150                 155                 160 


Arg Ile Ala Ser Ile Ser Lys Ser Leu Thr Met Val Ala Leu Ala Lys 
                165                 170                 175     


Leu Trp Glu Ala Gly Lys Leu Asp Leu Asp Ile Pro Val Gln His Tyr 
            180                 185                 190         


Val Pro Glu Phe Pro Glu Lys Glu Tyr Glu Gly Glu Lys Val Ser Val 
        195                 200                 205             


Thr Thr Arg Leu Leu Ile Ser His Leu Ser Gly Ile Arg His Tyr Glu 
    210                 215                 220                 


Lys Asp Ile Lys Lys Val Lys Glu Glu Lys Ala Tyr Lys Ala Leu Lys 
225                 230                 235                 240 


Met Met Lys Glu Asn Val Ala Phe Glu Gln Glu Lys Glu Gly Lys Ser 
                245                 250                 255     


Asn Glu Lys Asn Asp Phe Thr Lys Phe Lys Thr Glu Gln Glu Asn Glu 
            260                 265                 270         


Ala Lys Cys Arg Asn Ser Lys Pro Gly Lys Lys Lys Asn Asp Phe Glu 
        275                 280                 285             


Gln Gly Glu Leu Tyr Leu Arg Glu Lys Phe Glu Asn Ser Ile Glu Ser 
    290                 295                 300                 


Leu Arg Leu Phe Lys Asn Asp Pro Leu Phe Phe Lys Pro Gly Ser Gln 
305                 310                 315                 320 


Phe Leu Tyr Ser Thr Phe Gly Tyr Thr Leu Leu Ala Ala Ile Val Glu 
                325                 330                 335     


Arg Ala Ser Gly Cys Lys Tyr Leu Asp Tyr Met Gln Lys Ile Phe His 
            340                 345                 350         


Asp Leu Asp Met Leu Thr Thr Val Gln Glu Glu Asn Glu Pro Val Ile 
        355                 360                 365             


Tyr Asn Arg Ala Arg 
    370             


<210>  7633
<211>  525
<212>  PRT
<213>  Homo Sapiens

<400>  7633

Met Trp Glu Ala Gln Phe Leu Gly Leu Leu Phe Leu Gln Pro Leu Trp 
1               5                   10                  15      


Val Ala Pro Val Lys Pro Leu Gln Pro Gly Ala Glu Val Pro Val Val 
            20                  25                  30          


Trp Ala Gln Glu Gly Ala Pro Ala Gln Leu Pro Cys Ser Pro Thr Ile 
        35                  40                  45              


Pro Leu Gln Asp Leu Ser Leu Leu Arg Arg Ala Gly Val Thr Trp Gln 
    50                  55                  60                  


His Gln Pro Asp Ser Gly Pro Pro Ala Ala Ala Pro Gly His Pro Leu 
65                  70                  75                  80  


Ala Pro Gly Pro His Pro Ala Ala Pro Ser Ser Trp Gly Pro Arg Pro 
                85                  90                  95      


Arg Arg Tyr Thr Val Leu Ser Val Gly Pro Gly Gly Leu Arg Ser Gly 
            100                 105                 110         


Arg Leu Pro Leu Gln Pro Arg Val Gln Leu Asp Glu Arg Gly Arg Gln 
        115                 120                 125             


Arg Gly Asp Phe Ser Leu Trp Leu Arg Pro Ala Arg Arg Ala Asp Ala 
    130                 135                 140                 


Gly Glu Tyr Arg Ala Ala Val His Leu Arg Asp Arg Ala Leu Ser Cys 
145                 150                 155                 160 


Arg Leu Arg Leu Arg Leu Gly Gln Ala Ser Met Thr Ala Ser Pro Pro 
                165                 170                 175     


Gly Ser Leu Arg Ala Ser Asp Trp Val Ile Leu Asn Cys Ser Phe Ser 
            180                 185                 190         


Arg Pro Asp Arg Pro Ala Ser Val His Trp Phe Arg Asn Arg Gly Gln 
        195                 200                 205             


Gly Arg Val Pro Val Arg Glu Ser Pro His His His Leu Ala Glu Ser 
    210                 215                 220                 


Phe Leu Phe Leu Pro Gln Val Ser Pro Met Asp Ser Gly Pro Trp Gly 
225                 230                 235                 240 


Cys Ile Leu Thr Tyr Arg Asp Gly Phe Asn Val Ser Ile Met Tyr Asn 
                245                 250                 255     


Leu Thr Val Leu Gly Leu Glu Pro Pro Thr Pro Leu Thr Val Tyr Ala 
            260                 265                 270         


Gly Ala Gly Ser Arg Val Gly Leu Pro Cys Arg Leu Pro Ala Gly Val 
        275                 280                 285             


Gly Thr Arg Ser Phe Leu Thr Ala Lys Trp Thr Pro Pro Gly Gly Gly 
    290                 295                 300                 


Pro Asp Leu Leu Val Thr Gly Asp Asn Gly Asp Phe Thr Leu Arg Leu 
305                 310                 315                 320 


Glu Asp Val Ser Gln Ala Gln Ala Gly Thr Tyr Thr Cys His Ile His 
                325                 330                 335     


Leu Gln Glu Gln Gln Leu Asn Ala Thr Val Thr Leu Ala Ile Ile Thr 
            340                 345                 350         


Val Thr Pro Lys Ser Phe Gly Ser Pro Gly Ser Leu Gly Lys Leu Leu 
        355                 360                 365             


Cys Glu Val Thr Pro Val Ser Gly Gln Glu Arg Phe Val Trp Ser Ser 
    370                 375                 380                 


Leu Asp Thr Pro Ser Gln Arg Ser Phe Ser Gly Pro Trp Leu Glu Ala 
385                 390                 395                 400 


Gln Glu Ala Gln Leu Leu Ser Gln Pro Trp Gln Cys Gln Leu Tyr Gln 
                405                 410                 415     


Gly Glu Arg Leu Leu Gly Ala Ala Val Tyr Phe Thr Glu Leu Ser Ser 
            420                 425                 430         


Pro Gly Ala Gln Arg Ser Gly Arg Ala Pro Gly Ala Leu Pro Ala Gly 
        435                 440                 445             


His Leu Leu Leu Phe Leu Ile Leu Gly Val Leu Ser Leu Leu Leu Leu 
    450                 455                 460                 


Val Thr Gly Ala Phe Gly Phe His Leu Trp Arg Arg Gln Trp Arg Pro 
465                 470                 475                 480 


Arg Arg Phe Ser Ala Leu Glu Gln Gly Ile His Pro Pro Gln Ala Gln 
                485                 490                 495     


Ser Lys Ile Glu Glu Leu Glu Gln Glu Pro Glu Pro Glu Pro Glu Pro 
            500                 505                 510         


Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Gln Leu 
        515                 520                 525 


<210>  7634
<211>  360
<212>  PRT
<213>  Homo Sapiens

<400>  7634

Met Trp Glu Ala Gln Phe Leu Gly Leu Leu Phe Leu Gln Pro Leu Trp 
1               5                   10                  15      


Val Ala Pro Val Lys Pro Leu Gln Pro Gly Ala Glu Val Pro Val Val 
            20                  25                  30          


Trp Ala Gln Glu Gly Ala Pro Ala Gln Leu Pro Cys Ser Pro Thr Ile 
        35                  40                  45              


Pro Leu Gln Asp Leu Ser Leu Leu Arg Arg Ala Gly Val Thr Trp Gln 
    50                  55                  60                  


His Gln Pro Asp Ser Gly Pro Pro Ala Ala Ala Pro Gly His Pro Leu 
65                  70                  75                  80  


Ala Pro Gly Pro His Pro Ala Ala Pro Ser Ser Trp Gly Pro Arg Pro 
                85                  90                  95      


Arg Arg Tyr Thr Val Leu Ser Val Gly Pro Gly Gly Leu Arg Ser Gly 
            100                 105                 110         


Arg Leu Pro Leu Gln Pro Arg Val Gln Leu Asp Glu Arg Gly Arg Gln 
        115                 120                 125             


Arg Gly Asp Phe Ser Leu Trp Leu Arg Pro Ala Arg Arg Ala Asp Ala 
    130                 135                 140                 


Gly Glu Tyr Arg Ala Ala Val His Leu Arg Asp Arg Ala Leu Ser Cys 
145                 150                 155                 160 


Arg Leu Arg Leu Arg Leu Gly Gln Ala Ser Met Thr Ala Ser Pro Pro 
                165                 170                 175     


Gly Ser Leu Arg Ala Ser Asp Trp Val Ile Leu Asn Cys Ser Phe Ser 
            180                 185                 190         


Arg Pro Asp Arg Pro Ala Ser Val His Trp Phe Arg Asn Arg Gly Gln 
        195                 200                 205             


Gly Arg Val Pro Val Arg Glu Ser Pro His His His Leu Ala Glu Ser 
    210                 215                 220                 


Phe Leu Phe Leu Pro Gln Val Ser Pro Met Asp Ser Gly Pro Trp Gly 
225                 230                 235                 240 


Cys Ile Leu Thr Tyr Arg Asp Gly Phe Asn Val Ser Ile Met Tyr Asn 
                245                 250                 255     


Leu Thr Val Leu Gly Leu Glu Pro Pro Thr Pro Leu Thr Val Tyr Ala 
            260                 265                 270         


Gly Ala Gly Ser Arg Val Gly Leu Pro Cys Arg Leu Pro Ala Gly Val 
        275                 280                 285             


Gly Thr Arg Ser Phe Leu Thr Ala Lys Trp Thr Pro Pro Gly Gly Gly 
    290                 295                 300                 


Pro Asp Leu Leu Val Thr Gly Asp Asn Gly Asp Phe Thr Leu Arg Leu 
305                 310                 315                 320 


Glu Asp Val Ser Gln Ala Gln Ala Gly Thr Tyr Thr Cys His Ile His 
                325                 330                 335     


Leu Gln Glu Gln Gln Leu Asn Ala Thr Val Thr Leu Ala Ile Ile Thr 
            340                 345                 350         


Gly Gln Pro Gln Val Gly Lys Glu 
        355                 360 


<210>  7635
<211>  77
<212>  PRT
<213>  Homo Sapiens

<400>  7635

Met Glu Arg Glu Met Gly Ala Leu Pro Arg Pro Ser Ile Ser Ala Glu 
1               5                   10                  15      


Pro Gly Thr Val Ile Ser Pro Gly Ser His Val Thr Phe Met Cys Arg 
            20                  25                  30          


Gly Pro Val Gly Val Gln Thr Phe Arg Leu Glu Arg Glu Asp Arg Ala 
        35                  40                  45              


Lys Tyr Lys Asp Ser Tyr Asn Val Phe Arg Leu Gly Pro Ser Glu Ser 
    50                  55                  60                  


Glu Ala Arg Phe His Ile Asp Ser Val Ser Glu Gly Asn 
65                  70                  75          


<210>  7636
<211>  89
<212>  PRT
<213>  Homo Sapiens

<400>  7636

Met Glu Arg Glu Met Val Leu Cys Leu Ala Gln Thr Ile His Thr Gln 
1               5                   10                  15      


Glu Gly Ala Leu Pro Arg Pro Ser Ile Ser Ala Glu Pro Gly Thr Val 
            20                  25                  30          


Ile Ser Pro Gly Ser His Val Thr Phe Met Cys Arg Gly Pro Val Gly 
        35                  40                  45              


Val Gln Thr Phe Arg Leu Glu Arg Glu Asp Arg Ala Lys Tyr Lys Asp 
    50                  55                  60                  


Ser Tyr Asn Val Phe Arg Leu Gly Pro Ser Glu Ser Glu Ala Arg Phe 
65                  70                  75                  80  


His Ile Asp Ser Val Ser Glu Gly Asn 
                85                  


<210>  7637
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  7637

Met Ser Pro His Leu Thr Ala Leu Leu Gly Leu Val Leu Cys Leu Ala 
1               5                   10                  15      


Gln Thr Ile His Thr Gln Glu Gly Ala Leu Pro Arg Pro Ser Ile Ser 
            20                  25                  30          


Ala Glu Pro Gly Thr Val Ile Ser Pro Gly Ser His Val Thr Phe Met 
        35                  40                  45              


Cys Arg Gly Pro Val Gly Val Gln Thr Phe Arg Leu Glu Arg Glu Asp 
    50                  55                  60                  


Arg Ala Lys Tyr Lys Asp Ser Tyr Asn Val Phe Arg Leu Gly Pro Ser 
65                  70                  75                  80  


Glu Ser Glu Ala Arg Phe His Ile Asp Ser Val Ser Glu Gly Asn Ala 
                85                  90                  95      


Gly Leu Tyr Arg Cys Leu Tyr Tyr Lys Pro Pro Gly Trp Ser Glu His 
            100                 105                 110         


Ser Asp Phe Leu Glu Leu Leu Val Lys Glu Ser Ser Gly Gly Pro Asp 
        115                 120                 125             


Ser Pro Asp Thr Glu Pro Gly Ser Ser Ala Gly Thr Val Pro Gly Thr 
    130                 135                 140                 


Glu Ala Ser Gly Phe Asp Ala Pro 
145                 150         


<210>  7638
<211>  135
<212>  PRT
<213>  Homo Sapiens

<400>  7638

Met Ser Pro His Leu Thr Ala Leu Leu Gly Leu Val Leu Cys Leu Ala 
1               5                   10                  15      


Gln Thr Ile His Thr Gln Glu Gly Ala Leu Pro Arg Pro Ser Ile Ser 
            20                  25                  30          


Ala Glu Pro Gly Thr Val Ile Ser Pro Gly Ser His Val Thr Phe Met 
        35                  40                  45              


Cys Arg Gly Pro Val Gly Val Gln Thr Phe Arg Leu Glu Arg Glu Asp 
    50                  55                  60                  


Arg Ala Lys Tyr Lys Asp Ser Tyr Asn Val Phe Arg Leu Gly Pro Ser 
65                  70                  75                  80  


Glu Ser Glu Ala Arg Phe His Ile Asp Ser Val Ser Glu Gly Asn Ala 
                85                  90                  95      


Gly Leu Tyr Arg Cys Leu Tyr Tyr Lys Pro Pro Gly Trp Ser Glu His 
            100                 105                 110         


Ser Asp Phe Leu Glu Leu Leu Val Lys Gly Thr Val Pro Gly Thr Glu 
        115                 120                 125             


Ala Ser Gly Phe Asp Ala Pro 
    130                 135 


<210>  7639
<211>  123
<212>  PRT
<213>  Homo Sapiens

<400>  7639

Met Arg Phe Phe Val Pro Leu Phe Leu Val Gly Ile Leu Phe Pro Ala 
1               5                   10                  15      


Ile Leu Ala Lys Gln Phe Thr Lys Cys Glu Leu Ser Gln Leu Leu Lys 
            20                  25                  30          


Asp Ile Asp Gly Tyr Gly Gly Ile Ala Leu Pro Glu Leu Ile Cys Thr 
        35                  40                  45              


Met Phe His Thr Ser Gly Tyr Asp Thr Gln Ala Ile Val Glu Asn Asn 
    50                  55                  60                  


Glu Ser Thr Glu Tyr Gly Leu Phe Gln Ile Ser Asn Lys Leu Trp Cys 
65                  70                  75                  80  


Lys Ser Ser Gln Val Pro Gln Ser Arg Asn Ile Cys Asp Ile Ser Cys 
                85                  90                  95      


Asp Lys Phe Leu Asp Asp Asp Ile Thr Asp Asp Ile Met Cys Ala Lys 
            100                 105                 110         


Lys Ile Leu Asp Ile Lys Gly Ile Asp Tyr Trp 
        115                 120             


<210>  7640
<211>  142
<212>  PRT
<213>  Homo Sapiens

<400>  7640

Met Arg Phe Phe Val Pro Leu Phe Leu Val Gly Ile Leu Phe Pro Ala 
1               5                   10                  15      


Ile Leu Ala Lys Gln Phe Thr Lys Cys Glu Leu Ser Gln Leu Leu Lys 
            20                  25                  30          


Asp Ile Asp Gly Tyr Gly Gly Ile Ala Leu Pro Glu Leu Ile Cys Thr 
        35                  40                  45              


Met Phe His Thr Ser Gly Tyr Asp Thr Gln Ala Ile Val Glu Asn Asn 
    50                  55                  60                  


Glu Ser Thr Glu Tyr Gly Leu Phe Gln Ile Ser Asn Lys Leu Trp Cys 
65                  70                  75                  80  


Lys Ser Ser Gln Val Pro Gln Ser Arg Asn Ile Cys Asp Ile Ser Cys 
                85                  90                  95      


Asp Lys Phe Leu Asp Asp Asp Ile Thr Asp Asp Ile Met Cys Ala Lys 
            100                 105                 110         


Lys Ile Leu Asp Ile Lys Gly Ile Asp Tyr Trp Leu Ala His Lys Ala 
        115                 120                 125             


Leu Cys Thr Glu Lys Leu Glu Gln Trp Leu Cys Glu Lys Leu 
    130                 135                 140         


<210>  7641
<211>  217
<212>  PRT
<213>  Homo Sapiens

<400>  7641

Met Leu Ile Gly Gly Asn Ile Glu Val His Val Asn Pro Gly Asp Gly 
1               5                   10                  15      


Thr Gly Leu Arg Lys Ala Leu Leu His Ala Pro Thr Gly Thr Cys Ser 
            20                  25                  30          


Asp Gly Gln Ala His Ser Ile Ser Leu Val Arg Asn Arg Arg Ile Ile 
        35                  40                  45              


Thr Val Gln Leu Asp Glu Asn Asn Pro Val Glu Met Lys Leu Gly Thr 
    50                  55                  60                  


Leu Val Glu Ser Arg Thr Ile Asn Val Ser Asn Leu Tyr Val Gly Gly 
65                  70                  75                  80  


Ile Pro Glu Gly Glu Gly Thr Ser Leu Leu Thr Met Arg Arg Ser Phe 
                85                  90                  95      


His Gly Cys Ile Lys Asn Leu Ile Phe Asn Leu Glu Leu Leu Asp Phe 
            100                 105                 110         


Asn Ser Ala Val Gly Met Ser Lys Ser Thr Trp Thr Pro Ala Gly Cys 
        115                 120                 125             


Gln Lys Gly Leu Ser Trp Leu Pro Met Gln Arg Thr Lys Leu Leu Pro 
    130                 135                 140                 


Glu Pro Arg Ala Phe Pro Val Gly Ala Ala Ser Phe Thr Ile Ser Gln 
145                 150                 155                 160 


Val Gln Ser Ala Lys Glu Gly Leu Gly Gln Arg Glu Leu Lys Trp Gly 
                165                 170                 175     


Leu Ala Val Lys Val Pro Ala Lys Ala Gly Ala Gly Ala Gly Ala Gly 
            180                 185                 190         


Ala Val Leu Lys Ile Arg Ala Gly Thr Gly Arg Glu Arg Val Pro Gln 
        195                 200                 205             


Ala Thr Gln Met Thr Arg Pro Asn Pro 
    210                 215         


<210>  7642
<211>  3075
<212>  PRT
<213>  Homo Sapiens

<400>  7642

Met Arg Gly Gly Val Leu Leu Val Leu Leu Leu Cys Val Ala Ala Gln 
1               5                   10                  15      


Cys Arg Gln Arg Gly Leu Phe Pro Ala Ile Leu Asn Leu Ala Ser Asn 
            20                  25                  30          


Ala His Ile Ser Thr Asn Ala Thr Cys Gly Glu Lys Gly Pro Glu Met 
        35                  40                  45              


Phe Cys Lys Leu Val Glu His Val Pro Gly Arg Pro Val Arg Asn Pro 
    50                  55                  60                  


Gln Cys Arg Ile Cys Asp Gly Asn Ser Ala Asn Pro Arg Glu Arg His 
65                  70                  75                  80  


Pro Ile Ser His Ala Ile Asp Gly Thr Asn Asn Trp Trp Gln Ser Pro 
                85                  90                  95      


Ser Ile Gln Asn Gly Arg Glu Tyr His Trp Val Thr Ile Thr Leu Asp 
            100                 105                 110         


Leu Arg Gln Val Phe Gln Val Ala Tyr Val Ile Ile Lys Ala Ala Asn 
        115                 120                 125             


Ala Pro Arg Pro Gly Asn Trp Ile Leu Glu Arg Ser Leu Asp Gly Thr 
    130                 135                 140                 


Thr Phe Ser Pro Trp Gln Tyr Tyr Ala Val Ser Asp Ser Glu Cys Leu 
145                 150                 155                 160 


Ser Arg Tyr Asn Ile Thr Pro Arg Arg Gly Pro Pro Thr Tyr Arg Ala 
                165                 170                 175     


Asp Asp Glu Val Ile Cys Thr Ser Tyr Tyr Ser Arg Leu Val Pro Leu 
            180                 185                 190         


Glu His Gly Glu Ile His Thr Ser Leu Ile Asn Gly Arg Pro Ser Ala 
        195                 200                 205             


Asp Asp Leu Ser Pro Lys Leu Leu Glu Phe Thr Ser Ala Arg Tyr Ile 
    210                 215                 220                 


Arg Leu Arg Leu Gln Arg Ile Arg Thr Leu Asn Ala Asp Leu Met Thr 
225                 230                 235                 240 


Leu Ser His Arg Glu Pro Lys Glu Leu Asp Pro Ile Val Thr Arg Arg 
                245                 250                 255     


Tyr Tyr Tyr Ser Ile Lys Asp Ile Ser Val Gly Gly Met Cys Ile Cys 
            260                 265                 270         


Tyr Gly His Ala Ser Ser Cys Pro Trp Asp Glu Thr Thr Lys Lys Leu 
        275                 280                 285             


Gln Cys Gln Cys Glu His Asn Thr Cys Gly Glu Ser Cys Asn Arg Cys 
    290                 295                 300                 


Cys Pro Gly Tyr His Gln Gln Pro Trp Arg Pro Gly Thr Val Ser Ser 
305                 310                 315                 320 


Gly Asn Thr Cys Glu Ala Cys Asn Cys His Asn Lys Ala Lys Asp Cys 
                325                 330                 335     


Tyr Tyr Asp Glu Ser Val Ala Lys Gln Lys Lys Ser Leu Asn Thr Ala 
            340                 345                 350         


Gly Gln Phe Arg Gly Gly Gly Val Cys Ile Asn Cys Leu Gln Asn Thr 
        355                 360                 365             


Met Gly Ile Asn Cys Glu Thr Cys Ile Asp Gly Tyr Tyr Arg Pro His 
    370                 375                 380                 


Lys Val Ser Pro Tyr Glu Asp Glu Pro Cys Arg Pro Cys Asn Cys Asp 
385                 390                 395                 400 


Pro Val Gly Ser Leu Ser Ser Val Cys Ile Lys Asp Asp Leu His Ser 
                405                 410                 415     


Asp Leu His Asn Gly Lys Gln Pro Gly Gln Cys Pro Cys Lys Glu Gly 
            420                 425                 430         


Tyr Thr Gly Glu Lys Cys Asp Arg Cys Gln Leu Gly Tyr Lys Asp Tyr 
        435                 440                 445             


Pro Thr Cys Val Ser Cys Gly Cys Asn Pro Val Gly Ser Ala Ser Asp 
    450                 455                 460                 


Glu Pro Cys Thr Gly Pro Cys Val Cys Lys Glu Asn Val Glu Gly Lys 
465                 470                 475                 480 


Ala Cys Asp Arg Cys Lys Pro Gly Phe Tyr Asn Leu Lys Glu Lys Asn 
                485                 490                 495     


Pro Arg Gly Cys Ser Glu Cys Phe Cys Phe Gly Val Ser Asp Val Cys 
            500                 505                 510         


Ser Ser Leu Ser Trp Pro Val Gly Gln Val Asn Ser Met Ser Gly Trp 
        515                 520                 525             


Leu Val Thr Asp Leu Ile Ser Pro Arg Lys Ile Pro Ser Gln Gln Asp 
    530                 535                 540                 


Ala Leu Gly Gly Arg His Gln Val Ser Ile Asn Asn Thr Ala Val Met 
545                 550                 555                 560 


Gln Arg Leu Ala Pro Lys Tyr Tyr Trp Ala Ala Pro Glu Ala Tyr Leu 
                565                 570                 575     


Gly Asn Lys Leu Thr Ala Phe Gly Gly Phe Leu Lys Tyr Thr Val Ser 
            580                 585                 590         


Tyr Asp Ile Pro Val Glu Thr Val Asp Ser Asn Leu Met Ser His Ala 
        595                 600                 605             


Asp Val Ile Ile Lys Gly Asn Gly Leu Thr Leu Ser Thr Gln Ala Glu 
    610                 615                 620                 


Gly Leu Ser Leu Gln Pro Tyr Glu Glu Tyr Leu Asn Val Val Arg Leu 
625                 630                 635                 640 


Val Pro Glu Asn Phe Gln Asp Phe His Ser Lys Arg Gln Ile Asp Arg 
                645                 650                 655     


Asp Gln Leu Met Thr Val Leu Ala Asn Val Thr His Leu Leu Ile Arg 
            660                 665                 670         


Ala Asn Tyr Asn Ser Ala Lys Met Ala Leu Tyr Arg Leu Glu Ser Val 
        675                 680                 685             


Ser Leu Asp Ile Ala Ser Ser Asn Ala Ile Asp Leu Val Val Ala Ala 
    690                 695                 700                 


Asp Val Glu His Cys Glu Cys Pro Gln Gly Tyr Thr Gly Thr Ser Cys 
705                 710                 715                 720 


Glu Ser Cys Leu Ser Gly Tyr Tyr Arg Val Asp Gly Ile Leu Phe Gly 
                725                 730                 735     


Gly Ile Cys Gln Pro Cys Glu Cys His Gly His Ala Ala Glu Cys Asn 
            740                 745                 750         


Val His Gly Val Cys Ile Ala Cys Ala His Asn Thr Thr Gly Val His 
        755                 760                 765             


Cys Glu Gln Cys Leu Pro Gly Phe Tyr Gly Glu Pro Ser Arg Gly Thr 
    770                 775                 780                 


Pro Gly Asp Cys Gln Pro Cys Ala Cys Pro Leu Thr Ile Ala Ser Asn 
785                 790                 795                 800 


Asn Phe Ser Pro Thr Cys His Leu Asn Asp Gly Asp Glu Val Val Cys 
                805                 810                 815     


Asp Trp Cys Ala Pro Gly Tyr Ser Gly Ala Trp Cys Glu Arg Cys Ala 
            820                 825                 830         


Asp Gly Tyr Tyr Gly Asn Pro Thr Val Pro Gly Glu Ser Cys Val Pro 
        835                 840                 845             


Cys Asp Cys Ser Gly Asn Val Asp Pro Ser Glu Ala Gly His Cys Asp 
    850                 855                 860                 


Ser Val Thr Gly Glu Cys Leu Lys Cys Leu Gly Asn Thr Asp Gly Ala 
865                 870                 875                 880 


His Cys Glu Arg Cys Ala Asp Gly Phe Tyr Gly Asp Ala Val Thr Ala 
                885                 890                 895     


Lys Asn Cys Arg Ala Cys Glu Cys His Val Lys Gly Ser His Ser Ala 
            900                 905                 910         


Val Cys His Leu Glu Thr Gly Leu Cys Asp Cys Lys Pro Asn Val Thr 
        915                 920                 925             


Gly Gln Gln Cys Asp Gln Cys Leu His Gly Tyr Tyr Gly Leu Asp Ser 
    930                 935                 940                 


Gly His Gly Cys Arg Pro Cys Asn Cys Ser Val Ala Gly Ser Val Ser 
945                 950                 955                 960 


Asp Gly Cys Thr Asp Glu Gly Gln Cys His Cys Val Pro Gly Val Ala 
                965                 970                 975     


Gly Lys Arg Cys Asp Arg Cys Ala His Gly Phe Tyr Ala Tyr Gln Asp 
            980                 985                 990         


Gly Ser Cys Thr Pro Cys Asp Cys  Pro His Thr Gln Asn  Thr Cys Asp 
        995                 1000                 1005             


Pro Glu  Thr Gly Glu Cys Val  Cys Pro Pro His Thr  Gln Gly Val 
    1010                 1015                 1020             


Lys Cys  Glu Glu Cys Glu Asp  Gly His Trp Gly Tyr  Asp Ala Glu 
    1025                 1030                 1035             


Val Gly  Cys Gln Ala Cys Asn  Cys Ser Leu Val Gly  Ser Thr His 
    1040                 1045                 1050             


His Arg  Cys Asp Val Val Thr  Gly His Cys Gln Cys  Lys Ser Lys 
    1055                 1060                 1065             


Phe Gly  Gly Arg Ala Cys Asp  Gln Cys Ser Leu Gly  Tyr Arg Asp 
    1070                 1075                 1080             


Phe Pro  Asp Cys Val Pro Cys  Asp Cys Asp Leu Arg  Gly Thr Ser 
    1085                 1090                 1095             


Gly Asp  Ala Cys Asn Leu Glu  Gln Gly Leu Cys Gly  Cys Val Glu 
    1100                 1105                 1110             


Glu Thr  Gly Ala Cys Pro Cys  Lys Glu Asn Val Phe  Gly Pro Gln 
    1115                 1120                 1125             


Cys Asn  Glu Cys Arg Glu Gly  Thr Phe Ala Leu Arg  Ala Asp Asn 
    1130                 1135                 1140             


Pro Leu  Gly Cys Ser Pro Cys  Phe Cys Ser Gly Leu  Ser His Leu 
    1145                 1150                 1155             


Cys Ser  Glu Leu Glu Asp Tyr  Val Arg Thr Pro Val  Thr Leu Gly 
    1160                 1165                 1170             


Ser Asp  Gln Pro Leu Leu Arg  Val Val Ser Gln Ser  Asn Leu Arg 
    1175                 1180                 1185             


Gly Thr  Thr Glu Gly Val Tyr  Tyr Gln Ala Pro Asp  Phe Leu Leu 
    1190                 1195                 1200             


Asp Ala  Ala Thr Val Arg Gln  His Ile Arg Ala Glu  Pro Phe Tyr 
    1205                 1210                 1215             


Trp Arg  Leu Pro Gln Gln Phe  Gln Gly Asp Gln Leu  Met Ala Tyr 
    1220                 1225                 1230             


Gly Gly  Lys Leu Lys Tyr Ser  Val Ala Phe Tyr Ser  Leu Asp Gly 
    1235                 1240                 1245             


Val Gly  Thr Ser Asn Phe Glu  Pro Gln Val Leu Ile  Lys Gly Gly 
    1250                 1255                 1260             


Arg Ile  Arg Lys Gln Val Ile  Tyr Met Asp Ala Pro  Ala Pro Glu 
    1265                 1270                 1275             


Asn Gly  Val Arg Gln Glu Gln  Glu Val Ala Met Arg  Glu Asn Phe 
    1280                 1285                 1290             


Trp Lys  Tyr Phe Asn Ser Val  Ser Glu Lys Pro Val  Thr Arg Glu 
    1295                 1300                 1305             


Asp Phe  Met Ser Val Leu Ser  Asp Ile Glu Tyr Ile  Leu Ile Lys 
    1310                 1315                 1320             


Ala Ser  Tyr Gly Gln Gly Leu  Gln Gln Ser Arg Ile  Ser Asp Ile 
    1325                 1330                 1335             


Ser Met  Glu Val Gly Arg Lys  Ala Glu Lys Leu His  Pro Glu Glu 
    1340                 1345                 1350             


Glu Val  Ala Ser Leu Leu Glu  Asn Cys Val Cys Pro  Pro Gly Thr 
    1355                 1360                 1365             


Val Gly  Phe Ser Cys Gln Asp  Cys Ala Pro Gly Tyr  His Arg Gly 
    1370                 1375                 1380             


Lys Leu  Pro Ala Gly Ser Asp  Arg Gly Pro Arg Pro  Leu Val Ala 
    1385                 1390                 1395             


Pro Cys  Val Pro Cys Ser Cys  Asn Asn His Ser Asp  Thr Cys Asp 
    1400                 1405                 1410             


Pro Asn  Thr Gly Lys Cys Leu  Asn Cys Gly Asp Asn  Thr Ala Gly 
    1415                 1420                 1425             


Asp His  Cys Asp Val Cys Thr  Ser Gly Tyr Tyr Gly  Lys Val Thr 
    1430                 1435                 1440             


Gly Ser  Ala Ser Asp Cys Ala  Leu Cys Ala Cys Pro  His Ser Pro 
    1445                 1450                 1455             


Pro Ala  Ser Phe Ser Pro Thr  Cys Val Leu Glu Gly  Asp His Asp 
    1460                 1465                 1470             


Phe Arg  Cys Asp Ala Cys Leu  Leu Gly Tyr Glu Gly  Lys His Cys 
    1475                 1480                 1485             


Glu Arg  Cys Ser Ser Ser Tyr  Tyr Gly Asn Pro Gln  Thr Pro Gly 
    1490                 1495                 1500             


Gly Ser  Cys Gln Lys Cys Asp  Cys Asn Pro His Gly  Ser Val His 
    1505                 1510                 1515             


Gly Asp  Cys Asp Arg Thr Ser  Gly Gln Cys Val Cys  Arg Leu Gly 
    1520                 1525                 1530             


Ala Ser  Gly Leu Arg Cys Asp  Glu Cys Glu Pro Arg  His Ile Leu 
    1535                 1540                 1545             


Met Glu  Thr Asp Cys Val Ser  Cys Asp Asp Glu Cys  Val Gly Val 
    1550                 1555                 1560             


Leu Leu  Asn Asp Leu Asp Glu  Ile Gly Asp Ala Val  Leu Ser Leu 
    1565                 1570                 1575             


Asn Leu  Thr Gly Ile Ile Pro  Val Pro Tyr Gly Ile  Leu Ser Asn 
    1580                 1585                 1590             


Leu Glu  Asn Thr Thr Lys Tyr  Leu Gln Glu Ser Leu  Leu Lys Glu 
    1595                 1600                 1605             


Asn Met  Gln Lys Asp Leu Gly  Lys Ile Lys Leu Glu  Gly Val Ala 
    1610                 1615                 1620             


Glu Glu  Thr Asp Asn Leu Gln  Lys Lys Leu Thr Arg  Met Leu Ala 
    1625                 1630                 1635             


Ser Thr  Gln Lys Val Asn Arg  Ala Thr Glu Arg Ile  Phe Lys Glu 
    1640                 1645                 1650             


Ser Gln  Asp Leu Ala Ile Ala  Ile Glu Arg Leu Gln  Met Ser Ile 
    1655                 1660                 1665             


Thr Glu  Ile Met Glu Lys Thr  Thr Leu Asn Gln Thr  Leu Asp Glu 
    1670                 1675                 1680             


Asp Phe  Leu Leu Pro Asn Ser  Thr Leu Gln Asn Met  Gln Gln Asn 
    1685                 1690                 1695             


Gly Thr  Ser Leu Leu Glu Ile  Met Gln Ile Arg Asp  Phe Thr Gln 
    1700                 1705                 1710             


Leu His  Gln Asn Ala Thr Leu  Glu Leu Lys Ala Ala  Glu Asp Leu 
    1715                 1720                 1725             


Leu Ser  Gln Ile Gln Glu Asn  Tyr Gln Lys Pro Leu  Glu Glu Leu 
    1730                 1735                 1740             


Glu Val  Leu Lys Glu Ala Ala  Ser His Val Leu Ser  Lys His Asn 
    1745                 1750                 1755             


Asn Glu  Leu Lys Ala Ala Glu  Ala Leu Val Arg Glu  Ala Glu Ala 
    1760                 1765                 1770             


Lys Met  Gln Glu Ser Asn His  Leu Leu Leu Met Val  Asn Ala Asn 
    1775                 1780                 1785             


Leu Arg  Glu Phe Ser Asp Lys  Lys Leu His Val Gln  Glu Glu Gln 
    1790                 1795                 1800             


Asn Leu  Thr Ser Glu Leu Ile  Val Gln Gly Arg Gly  Leu Ile Asp 
    1805                 1810                 1815             


Ala Ala  Ala Ala Gln Thr Asp  Ala Val Gln Asp Ala  Leu Glu His 
    1820                 1825                 1830             


Leu Glu  Asp His Gln Asp Lys  Leu Leu Leu Trp Ser  Ala Lys Ile 
    1835                 1840                 1845             


Arg His  His Ile Asp Asp Leu  Val Met His Met Ser  Gln Arg Asn 
    1850                 1855                 1860             


Ala Val  Asp Leu Val Tyr Arg  Ala Glu Asp His Ala  Ala Glu Phe 
    1865                 1870                 1875             


Gln Arg  Leu Ala Asp Val Leu  Tyr Ser Gly Leu Glu  Asn Ile Arg 
    1880                 1885                 1890             


Asn Val  Ser Leu Asn Ala Thr  Ser Ala Ala Tyr Val  His Tyr Asn 
    1895                 1900                 1905             


Ile Gln  Ser Leu Ile Glu Glu  Ser Glu Glu Leu Ala  Arg Asp Ala 
    1910                 1915                 1920             


His Arg  Thr Val Thr Glu Thr  Ser Leu Leu Ser Glu  Ser Leu Val 
    1925                 1930                 1935             


Ser Asn  Gly Lys Ala Ala Val  Gln Arg Ser Ser Arg  Phe Leu Lys 
    1940                 1945                 1950             


Glu Gly  Asn Asn Leu Ser Arg  Lys Leu Pro Gly Ile  Ala Leu Glu 
    1955                 1960                 1965             


Leu Ser  Glu Leu Arg Asn Lys  Thr Asn Arg Phe Gln  Glu Asn Ala 
    1970                 1975                 1980             


Val Glu  Ile Thr Arg Gln Thr  Asn Glu Ser Leu Leu  Ile Leu Arg 
    1985                 1990                 1995             


Ala Ile  Pro Lys Gly Ile Arg  Asp Lys Gly Ala Lys  Thr Lys Glu 
    2000                 2005                 2010             


Leu Ala  Thr Ser Ala Ser Gln  Ser Ala Val Ser Thr  Leu Arg Asp 
    2015                 2020                 2025             


Val Ala  Gly Leu Ser Gln Glu  Leu Leu Asn Thr Ser  Ala Ser Leu 
    2030                 2035                 2040             


Ser Arg  Val Asn Thr Thr Leu  Arg Glu Thr His Gln  Leu Leu Gln 
    2045                 2050                 2055             


Asp Ser  Thr Met Ala Thr Leu  Leu Ala Gly Arg Lys  Val Lys Asp 
    2060                 2065                 2070             


Val Glu  Ile Gln Ala Asn Leu  Leu Phe Asp Arg Leu  Lys Pro Leu 
    2075                 2080                 2085             


Lys Met  Leu Glu Glu Asn Leu  Ser Arg Asn Leu Ser  Glu Ile Lys 
    2090                 2095                 2100             


Leu Leu  Ile Ser Gln Ala Arg  Lys Gln Ala Ala Ser  Ile Lys Val 
    2105                 2110                 2115             


Ala Val  Ser Ala Asp Arg Asp  Cys Ile Arg Ala Tyr  Gln Pro Gln 
    2120                 2125                 2130             


Ile Ser  Ser Thr Asn Tyr Asn  Thr Leu Thr Leu Asn  Val Lys Thr 
    2135                 2140                 2145             


Gln Glu  Pro Asp Asn Leu Leu  Phe Tyr Leu Gly Ser  Ser Thr Ala 
    2150                 2155                 2160             


Ser Asp  Phe Leu Ala Val Glu  Met Arg Arg Gly Arg  Val Ala Phe 
    2165                 2170                 2175             


Leu Trp  Asp Leu Gly Ser Gly  Ser Thr Arg Leu Glu  Phe Pro Asp 
    2180                 2185                 2190             


Phe Pro  Ile Asp Asp Asn Arg  Trp His Ser Ile His  Val Ala Arg 
    2195                 2200                 2205             


Phe Gly  Asn Ile Gly Ser Leu  Ser Val Lys Glu Met  Ser Ser Asn 
    2210                 2215                 2220             


Gln Lys  Ser Pro Thr Lys Thr  Ser Lys Ser Pro Gly  Thr Ala Asn 
    2225                 2230                 2235             


Val Leu  Asp Val Asn Asn Ser  Thr Leu Met Phe Val  Gly Gly Leu 
    2240                 2245                 2250             


Gly Gly  Gln Ile Lys Lys Ser  Pro Ala Val Lys Val  Thr His Phe 
    2255                 2260                 2265             


Lys Gly  Cys Leu Gly Glu Ala  Phe Leu Asn Gly Lys  Ser Ile Gly 
    2270                 2275                 2280             


Leu Trp  Asn Tyr Ile Glu Arg  Glu Gly Lys Cys Arg  Gly Cys Phe 
    2285                 2290                 2295             


Gly Ser  Ser Gln Asn Glu Asp  Pro Ser Phe His Phe  Asp Gly Ser 
    2300                 2305                 2310             


Gly Tyr  Ser Val Val Glu Lys  Ser Leu Pro Ala Thr  Val Thr Gln 
    2315                 2320                 2325             


Ile Ile  Met Leu Phe Asn Thr  Phe Ser Pro Asn Gly  Leu Leu Leu 
    2330                 2335                 2340             


Tyr Leu  Gly Ser Tyr Gly Thr  Lys Asp Phe Leu Ser  Ile Glu Leu 
    2345                 2350                 2355             


Phe Arg  Gly Arg Val Lys Val  Met Thr Asp Leu Gly  Ser Gly Pro 
    2360                 2365                 2370             


Ile Thr  Leu Leu Thr Asp Arg  Arg Tyr Asn Asn Gly  Thr Trp Tyr 
    2375                 2380                 2385             


Lys Ile  Ala Phe Gln Arg Asn  Arg Lys Gln Gly Val  Leu Ala Val 
    2390                 2395                 2400             


Ile Asp  Ala Tyr Asn Thr Ser  Asn Lys Glu Thr Lys  Gln Gly Glu 
    2405                 2410                 2415             


Thr Pro  Gly Ala Ser Ser Asp  Leu Asn Arg Leu Asp  Lys Asp Pro 
    2420                 2425                 2430             


Ile Tyr  Val Gly Gly Leu Pro  Arg Ser Arg Val Val  Arg Arg Gly 
    2435                 2440                 2445             


Val Thr  Thr Lys Ser Phe Val  Gly Cys Ile Lys Asn  Leu Glu Ile 
    2450                 2455                 2460             


Ser Arg  Ser Thr Phe Asp Leu  Leu Arg Asn Ser Tyr  Gly Val Arg 
    2465                 2470                 2475             


Lys Gly  Cys Leu Leu Glu Pro  Ile Arg Ser Val Ser  Phe Leu Lys 
    2480                 2485                 2490             


Gly Gly  Tyr Ile Glu Leu Pro  Pro Lys Ser Leu Ser  Pro Glu Ser 
    2495                 2500                 2505             


Glu Trp  Leu Val Thr Phe Ala  Thr Thr Asn Ser Ser  Gly Ile Ile 
    2510                 2515                 2520             


Leu Ala  Ala Leu Gly Gly Asp  Val Glu Lys Arg Gly  Asp Arg Glu 
    2525                 2530                 2535             


Glu Ala  His Val Pro Phe Phe  Ser Val Met Leu Ile  Gly Gly Asn 
    2540                 2545                 2550             


Ile Glu  Val His Val Asn Pro  Gly Asp Gly Thr Gly  Leu Arg Lys 
    2555                 2560                 2565             


Ala Leu  Leu His Ala Pro Thr  Gly Thr Cys Ser Asp  Gly Gln Ala 
    2570                 2575                 2580             


His Ser  Ile Ser Leu Val Arg  Asn Arg Arg Ile Ile  Thr Val Gln 
    2585                 2590                 2595             


Leu Asp  Glu Asn Asn Pro Val  Glu Met Lys Leu Gly  Thr Leu Val 
    2600                 2605                 2610             


Glu Ser  Arg Thr Ile Asn Val  Ser Asn Leu Tyr Val  Gly Gly Ile 
    2615                 2620                 2625             


Pro Glu  Gly Glu Gly Thr Ser  Leu Leu Thr Met Arg  Arg Ser Phe 
    2630                 2635                 2640             


His Gly  Cys Ile Lys Asn Leu  Ile Phe Asn Leu Glu  Leu Leu Asp 
    2645                 2650                 2655             


Phe Asn  Ser Ala Val Gly His  Glu Gln Val Asp Leu  Asp Thr Cys 
    2660                 2665                 2670             


Trp Leu  Ser Glu Arg Pro Lys  Leu Ala Pro Asp Ala  Glu Asp Ser 
    2675                 2680                 2685             


Lys Leu  Leu Pro Glu Pro Arg  Ala Phe Pro Glu Gln  Cys Val Val 
    2690                 2695                 2700             


Asp Ala  Ala Leu Glu Tyr Val  Pro Gly Ala His Gln  Phe Gly Leu 
    2705                 2710                 2715             


Thr Gln  Asn Ser His Phe Ile  Leu Pro Phe Asn Gln  Ser Ala Val 
    2720                 2725                 2730             


Arg Lys  Lys Leu Ser Val Glu  Leu Ser Ile Arg Thr  Phe Ala Ser 
    2735                 2740                 2745             


Ser Gly  Leu Ile Tyr Tyr Met  Ala His Gln Asn Gln  Ala Asp Tyr 
    2750                 2755                 2760             


Ala Val  Leu Gln Leu His Gly  Gly Arg Leu His Phe  Met Phe Asp 
    2765                 2770                 2775             


Leu Gly  Lys Gly Arg Thr Lys  Val Ser His Pro Ala  Leu Leu Ser 
    2780                 2785                 2790             


Asp Gly  Lys Trp His Thr Val  Lys Thr Asp Tyr Val  Lys Arg Lys 
    2795                 2800                 2805             


Gly Phe  Ile Thr Val Asp Gly  Arg Glu Ser Pro Met  Val Thr Val 
    2810                 2815                 2820             


Val Gly  Asp Gly Thr Met Leu  Asp Val Glu Gly Leu  Phe Tyr Leu 
    2825                 2830                 2835             


Gly Gly  Leu Pro Ser Gln Tyr  Gln Ala Arg Lys Ile  Gly Asn Ile 
    2840                 2845                 2850             


Thr His  Ser Ile Pro Ala Cys  Ile Gly Asp Val Thr  Val Asn Ser 
    2855                 2860                 2865             


Lys Gln  Leu Asp Lys Asp Ser  Pro Val Ser Ala Phe  Thr Val Asn 
    2870                 2875                 2880             


Arg Cys  Tyr Ala Val Ala Gln  Glu Gly Thr Tyr Phe  Asp Gly Ser 
    2885                 2890                 2895             


Gly Tyr  Ala Ala Leu Val Lys  Glu Gly Tyr Lys Val  Gln Ser Asp 
    2900                 2905                 2910             


Val Asn  Ile Thr Leu Glu Phe  Arg Thr Ser Ser Gln  Asn Gly Val 
    2915                 2920                 2925             


Leu Leu  Gly Ile Ser Thr Ala  Lys Val Asp Ala Ile  Gly Leu Glu 
    2930                 2935                 2940             


Leu Val  Asp Gly Lys Val Leu  Phe His Val Asn Asn  Gly Ala Gly 
    2945                 2950                 2955             


Arg Ile  Thr Ala Ala Tyr Glu  Pro Lys Thr Ala Thr  Val Leu Cys 
    2960                 2965                 2970             


Asp Gly  Lys Trp His Thr Leu  Gln Ala Asn Lys Ser  Lys His Arg 
    2975                 2980                 2985             


Ile Thr  Leu Ile Val Asp Gly  Asn Ala Val Gly Ala  Glu Ser Pro 
    2990                 2995                 3000             


His Thr  Gln Ser Thr Ser Val  Asp Thr Asn Asn Pro  Ile Tyr Val 
    3005                 3010                 3015             


Gly Gly  Tyr Pro Ala Gly Val  Lys Gln Lys Cys Leu  Arg Ser Gln 
    3020                 3025                 3030             


Thr Ser  Phe Arg Gly Cys Leu  Arg Lys Leu Ala Leu  Ile Lys Ser 
    3035                 3040                 3045             


Pro Gln  Val Gln Ser Phe Asp  Phe Ser Arg Ala Phe  Glu Leu His 
    3050                 3055                 3060             


Gly Val  Phe Leu His Ser Cys  Pro Gly Thr Glu Ser  
    3065                 3070                 3075 


<210>  7643
<211>  3122
<212>  PRT
<213>  Homo Sapiens

<400>  7643

Met Pro Gly Ala Ala Gly Val Leu Leu Leu Leu Leu Leu Ser Gly Gly 
1               5                   10                  15      


Leu Gly Gly Val Gln Ala Gln Arg Pro Gln Gln Gln Arg Gln Ser Gln 
            20                  25                  30          


Ala His Gln Gln Arg Gly Leu Phe Pro Ala Val Leu Asn Leu Ala Ser 
        35                  40                  45              


Asn Ala Leu Ile Thr Thr Asn Ala Thr Cys Gly Glu Lys Gly Pro Glu 
    50                  55                  60                  


Met Tyr Cys Lys Leu Val Glu His Val Pro Gly Gln Pro Val Arg Asn 
65                  70                  75                  80  


Pro Gln Cys Arg Ile Cys Asn Gln Asn Ser Ser Asn Pro Asn Gln Arg 
                85                  90                  95      


His Pro Ile Thr Asn Ala Ile Asp Gly Lys Asn Thr Trp Trp Gln Ser 
            100                 105                 110         


Pro Ser Ile Lys Asn Gly Ile Glu Tyr His Tyr Val Thr Ile Thr Leu 
        115                 120                 125             


Asp Leu Gln Gln Val Phe Gln Ile Ala Tyr Val Ile Val Lys Ala Ala 
    130                 135                 140                 


Asn Ser Pro Arg Pro Gly Asn Trp Ile Leu Glu Arg Ser Leu Asp Asp 
145                 150                 155                 160 


Val Glu Tyr Lys Pro Trp Gln Tyr His Ala Val Thr Asp Thr Glu Cys 
                165                 170                 175     


Leu Thr Leu Tyr Asn Ile Tyr Pro Arg Thr Gly Pro Pro Ser Tyr Ala 
            180                 185                 190         


Lys Asp Asp Glu Val Ile Cys Thr Ser Phe Tyr Ser Lys Ile His Pro 
        195                 200                 205             


Leu Glu Asn Gly Glu Ile His Ile Ser Leu Ile Asn Gly Arg Pro Ser 
    210                 215                 220                 


Ala Asp Asp Pro Ser Pro Glu Leu Leu Glu Phe Thr Ser Ala Arg Tyr 
225                 230                 235                 240 


Ile Arg Leu Arg Phe Gln Arg Ile Arg Thr Leu Asn Ala Asp Leu Met 
                245                 250                 255     


Met Phe Ala His Lys Asp Pro Arg Glu Ile Asp Pro Ile Val Thr Arg 
            260                 265                 270         


Arg Tyr Tyr Tyr Ser Val Lys Asp Ile Ser Val Gly Gly Met Cys Ile 
        275                 280                 285             


Cys Tyr Gly His Ala Arg Ala Cys Pro Leu Asp Pro Ala Thr Asn Lys 
    290                 295                 300                 


Ser Arg Cys Glu Cys Glu His Asn Thr Cys Gly Asp Ser Cys Asp Gln 
305                 310                 315                 320 


Cys Cys Pro Gly Phe His Gln Lys Pro Trp Arg Ala Gly Thr Phe Leu 
                325                 330                 335     


Thr Lys Thr Glu Cys Glu Ala Cys Asn Cys His Gly Lys Ala Glu Glu 
            340                 345                 350         


Cys Tyr Tyr Asp Glu Asn Val Ala Arg Arg Asn Leu Ser Leu Asn Ile 
        355                 360                 365             


Arg Gly Lys Tyr Ile Gly Gly Gly Val Cys Ile Asn Cys Thr Gln Asn 
    370                 375                 380                 


Thr Ala Gly Ile Asn Cys Glu Thr Cys Thr Asp Gly Phe Phe Arg Pro 
385                 390                 395                 400 


Lys Gly Val Ser Pro Asn Tyr Pro Arg Pro Cys Gln Pro Cys His Cys 
                405                 410                 415     


Asp Pro Ile Gly Ser Leu Asn Glu Val Cys Val Lys Asp Glu Lys His 
            420                 425                 430         


Ala Arg Arg Gly Leu Ala Pro Gly Ser Cys His Cys Lys Thr Gly Phe 
        435                 440                 445             


Gly Gly Val Ser Cys Asp Arg Cys Ala Arg Gly Tyr Thr Gly Tyr Pro 
    450                 455                 460                 


Asp Cys Lys Ala Cys Asn Cys Ser Gly Leu Gly Ser Lys Asn Glu Asp 
465                 470                 475                 480 


Pro Cys Phe Gly Pro Cys Ile Cys Lys Glu Asn Val Glu Gly Gly Asp 
                485                 490                 495     


Cys Ser Arg Cys Lys Ser Gly Phe Phe Asn Leu Gln Glu Asp Asn Trp 
            500                 505                 510         


Lys Gly Cys Asp Glu Cys Phe Cys Ser Gly Val Ser Asn Arg Cys Gln 
        515                 520                 525             


Ser Ser Tyr Trp Thr Tyr Gly Lys Ile Gln Asp Met Ser Gly Trp Tyr 
    530                 535                 540                 


Leu Thr Asp Leu Pro Gly Arg Ile Arg Val Ala Pro Gln Gln Asp Asp 
545                 550                 555                 560 


Leu Asp Ser Pro Gln Gln Ile Ser Ile Ser Asn Ala Glu Ala Arg Gln 
                565                 570                 575     


Ala Leu Pro His Ser Tyr Tyr Trp Ser Ala Pro Ala Pro Tyr Leu Gly 
            580                 585                 590         


Asn Lys Leu Pro Ala Val Gly Gly Gln Leu Thr Phe Thr Ile Ser Tyr 
        595                 600                 605             


Asp Leu Glu Glu Glu Glu Glu Asp Thr Glu Arg Val Leu Gln Leu Met 
    610                 615                 620                 


Ile Ile Leu Glu Gly Asn Asp Leu Ser Ile Ser Thr Ala Gln Asp Glu 
625                 630                 635                 640 


Val Tyr Leu His Pro Ser Glu Glu His Thr Asn Val Leu Leu Leu Lys 
                645                 650                 655     


Glu Glu Ser Phe Thr Ile His Gly Thr His Phe Pro Val Arg Arg Lys 
            660                 665                 670         


Glu Phe Met Thr Val Leu Ala Asn Leu Lys Arg Val Leu Leu Gln Ile 
        675                 680                 685             


Thr Tyr Ser Phe Gly Met Asp Ala Ile Phe Arg Leu Ser Ser Val Asn 
    690                 695                 700                 


Leu Glu Ser Ala Val Ser Tyr Pro Thr Asp Gly Ser Ile Ala Ala Ala 
705                 710                 715                 720 


Val Glu Val Cys Gln Cys Pro Pro Gly Tyr Thr Gly Ser Ser Cys Glu 
                725                 730                 735     


Ser Cys Trp Pro Arg His Arg Arg Val Asn Gly Thr Ile Phe Gly Gly 
            740                 745                 750         


Ile Cys Glu Pro Cys Gln Cys Phe Gly His Ala Glu Ser Cys Asp Asp 
        755                 760                 765             


Val Thr Gly Glu Cys Leu Asn Cys Lys Asp His Thr Gly Gly Pro Tyr 
    770                 775                 780                 


Cys Asp Lys Cys Leu Pro Gly Phe Tyr Gly Glu Pro Thr Lys Gly Thr 
785                 790                 795                 800 


Ser Glu Asp Cys Gln Pro Cys Ala Cys Pro Leu Asn Ile Pro Ser Asn 
                805                 810                 815     


Asn Phe Ser Pro Thr Cys His Leu Asp Arg Ser Leu Gly Leu Ile Cys 
            820                 825                 830         


Asp Gly Cys Pro Val Gly Tyr Thr Gly Pro Arg Cys Glu Arg Cys Ala 
        835                 840                 845             


Glu Gly Tyr Phe Gly Gln Pro Ser Val Pro Gly Gly Ser Cys Gln Pro 
    850                 855                 860                 


Cys Gln Cys Asn Asp Asn Leu Asp Phe Ser Ile Pro Gly Ser Cys Asp 
865                 870                 875                 880 


Ser Leu Ser Gly Ser Cys Leu Ile Cys Lys Pro Gly Thr Thr Gly Arg 
                885                 890                 895     


Tyr Cys Glu Leu Cys Ala Asp Gly Tyr Phe Gly Asp Ala Val Asp Ala 
            900                 905                 910         


Lys Asn Cys Gln Pro Cys Arg Cys Asn Ala Gly Gly Ser Phe Ser Glu 
        915                 920                 925             


Val Cys His Ser Gln Thr Gly Gln Cys Glu Cys Arg Ala Asn Val Gln 
    930                 935                 940                 


Gly Gln Arg Cys Asp Lys Cys Lys Ala Gly Thr Phe Gly Leu Gln Ser 
945                 950                 955                 960 


Ala Arg Gly Cys Val Pro Cys Asn Cys Asn Ser Phe Gly Ser Lys Ser 
                965                 970                 975     


Phe Asp Cys Glu Glu Ser Gly Gln Cys Trp Cys Gln Pro Gly Val Thr 
            980                 985                 990         


Gly Lys Lys Cys Asp Arg Cys Ala  His Gly Tyr Phe Asn  Phe Gln Glu 
        995                 1000                 1005             


Gly Gly  Cys Thr Ala Cys Glu  Cys Ser His Leu Gly  Asn Asn Cys 
    1010                 1015                 1020             


Asp Pro  Lys Thr Gly Arg Cys  Ile Cys Pro Pro Asn  Thr Ile Gly 
    1025                 1030                 1035             


Glu Lys  Cys Ser Lys Cys Ala  Pro Asn Thr Trp Gly  His Ser Ile 
    1040                 1045                 1050             


Thr Thr  Gly Cys Lys Ala Cys  Asn Cys Ser Thr Val  Gly Ser Leu 
    1055                 1060                 1065             


Asp Phe  Gln Cys Asn Val Asn  Thr Gly Gln Cys Asn  Cys His Pro 
    1070                 1075                 1080             


Lys Phe  Ser Gly Ala Lys Cys  Thr Glu Cys Ser Arg  Gly His Trp 
    1085                 1090                 1095             


Asn Tyr  Pro Arg Cys Asn Leu  Cys Asp Cys Phe Leu  Pro Gly Thr 
    1100                 1105                 1110             


Asp Ala  Thr Thr Cys Asp Ser  Glu Thr Lys Lys Cys  Ser Cys Ser 
    1115                 1120                 1125             


Asp Gln  Thr Gly Gln Cys Thr  Cys Lys Val Asn Val  Glu Gly Ile 
    1130                 1135                 1140             


His Cys  Asp Arg Cys Arg Pro  Gly Lys Phe Gly Leu  Asp Ala Lys 
    1145                 1150                 1155             


Asn Pro  Leu Gly Cys Ser Ser  Cys Tyr Cys Phe Gly  Thr Thr Thr 
    1160                 1165                 1170             


Gln Cys  Ser Glu Ala Lys Gly  Leu Ile Arg Thr Trp  Val Thr Leu 
    1175                 1180                 1185             


Lys Ala  Glu Gln Thr Ile Leu  Pro Leu Val Asp Glu  Ala Leu Gln 
    1190                 1195                 1200             


His Thr  Thr Thr Lys Gly Ile  Val Phe Gln His Pro  Glu Ile Val 
    1205                 1210                 1215             


Ala His  Met Asp Leu Met Arg  Glu Asp Leu His Leu  Glu Pro Phe 
    1220                 1225                 1230             


Tyr Trp  Lys Leu Pro Glu Gln  Phe Glu Gly Lys Lys  Leu Met Ala 
    1235                 1240                 1245             


Tyr Gly  Gly Lys Leu Lys Tyr  Ala Ile Tyr Phe Glu  Ala Arg Glu 
    1250                 1255                 1260             


Glu Thr  Gly Phe Ser Thr Tyr  Asn Pro Gln Val Ile  Ile Arg Gly 
    1265                 1270                 1275             


Gly Thr  Pro Thr His Ala Arg  Ile Ile Val Arg His  Met Ala Ala 
    1280                 1285                 1290             


Pro Leu  Ile Gly Gln Leu Thr  Arg His Glu Ile Glu  Met Thr Glu 
    1295                 1300                 1305             


Lys Glu  Trp Lys Tyr Tyr Gly  Asp Asp Pro Arg Val  His Arg Thr 
    1310                 1315                 1320             


Val Thr  Arg Glu Asp Phe Leu  Asp Ile Leu Tyr Asp  Ile His Tyr 
    1325                 1330                 1335             


Ile Leu  Ile Lys Ala Thr Tyr  Gly Asn Phe Met Arg  Gln Ser Arg 
    1340                 1345                 1350             


Ile Ser  Glu Ile Ser Met Glu  Val Ala Glu Gln Gly  Arg Gly Thr 
    1355                 1360                 1365             


Thr Met  Thr Pro Pro Ala Asp  Leu Ile Glu Lys Cys  Asp Cys Pro 
    1370                 1375                 1380             


Leu Gly  Tyr Ser Gly Leu Ser  Cys Glu Ala Cys Leu  Pro Gly Phe 
    1385                 1390                 1395             


Tyr Arg  Leu Arg Ser Gln Pro  Gly Gly Arg Thr Pro  Gly Pro Thr 
    1400                 1405                 1410             


Leu Gly  Thr Cys Val Pro Cys  Gln Cys Asn Gly His  Ser Ser Leu 
    1415                 1420                 1425             


Cys Asp  Pro Glu Thr Ser Ile  Cys Gln Asn Cys Gln  His His Thr 
    1430                 1435                 1440             


Ala Gly  Asp Phe Cys Glu Arg  Cys Ala Leu Gly Tyr  Tyr Gly Ile 
    1445                 1450                 1455             


Val Lys  Gly Leu Pro Asn Asp  Cys Gln Gln Cys Ala  Cys Pro Leu 
    1460                 1465                 1470             


Ile Ser  Ser Ser Asn Asn Phe  Ser Pro Ser Cys Val  Ala Glu Gly 
    1475                 1480                 1485             


Leu Asp  Asp Tyr Arg Cys Thr  Ala Cys Pro Arg Gly  Tyr Glu Gly 
    1490                 1495                 1500             


Gln Tyr  Cys Glu Arg Cys Ala  Pro Gly Tyr Thr Gly  Ser Pro Gly 
    1505                 1510                 1515             


Asn Pro  Gly Gly Ser Cys Gln  Glu Cys Glu Cys Asp  Pro Tyr Gly 
    1520                 1525                 1530             


Ser Leu  Pro Val Pro Cys Asp  Pro Val Thr Gly Phe  Cys Thr Cys 
    1535                 1540                 1545             


Arg Pro  Gly Ala Thr Gly Arg  Lys Cys Asp Gly Cys  Lys His Trp 
    1550                 1555                 1560             


His Ala  Arg Glu Gly Trp Glu  Cys Val Phe Cys Gly  Asp Glu Cys 
    1565                 1570                 1575             


Thr Gly  Leu Leu Leu Gly Asp  Leu Ala Arg Leu Glu  Gln Met Val 
    1580                 1585                 1590             


Met Ser  Ile Asn Leu Thr Gly  Pro Leu Pro Ala Pro  Tyr Lys Met 
    1595                 1600                 1605             


Leu Tyr  Gly Leu Glu Asn Met  Thr Gln Glu Leu Lys  His Leu Leu 
    1610                 1615                 1620             


Ser Pro  Gln Arg Ala Pro Glu  Arg Leu Ile Gln Leu  Ala Glu Gly 
    1625                 1630                 1635             


Asn Leu  Asn Thr Leu Val Thr  Glu Met Asn Glu Leu  Leu Thr Arg 
    1640                 1645                 1650             


Ala Thr  Lys Val Thr Ala Asp  Gly Glu Gln Thr Gly  Gln Asp Ala 
    1655                 1660                 1665             


Glu Arg  Thr Asn Thr Arg Ala  Lys Ser Leu Gly Glu  Phe Ile Lys 
    1670                 1675                 1680             


Glu Leu  Ala Arg Asp Ala Glu  Ala Val Asn Glu Lys  Ala Ile Lys 
    1685                 1690                 1695             


Leu Asn  Glu Thr Leu Gly Thr  Arg Asp Glu Ala Phe  Glu Arg Asn 
    1700                 1705                 1710             


Leu Glu  Gly Leu Gln Lys Glu  Ile Asp Gln Met Ile  Lys Glu Leu 
    1715                 1720                 1725             


Arg Arg  Lys Asn Leu Glu Thr  Gln Lys Glu Ile Ala  Glu Asp Glu 
    1730                 1735                 1740             


Leu Val  Ala Ala Glu Ala Leu  Leu Lys Lys Val Lys  Lys Leu Phe 
    1745                 1750                 1755             


Gly Glu  Ser Arg Gly Glu Asn  Glu Glu Met Glu Lys  Asp Leu Arg 
    1760                 1765                 1770             


Glu Lys  Leu Ala Asp Tyr Lys  Asn Lys Val Asp Asp  Ala Trp Asp 
    1775                 1780                 1785             


Leu Leu  Arg Glu Ala Thr Asp  Lys Ile Arg Glu Ala  Asn Arg Leu 
    1790                 1795                 1800             


Phe Ala  Val Asn Gln Lys Asn  Met Thr Ala Leu Glu  Lys Lys Lys 
    1805                 1810                 1815             


Glu Ala  Val Glu Ser Gly Lys  Arg Gln Ile Glu Asn  Thr Leu Lys 
    1820                 1825                 1830             


Glu Gly  Asn Asp Ile Leu Asp  Glu Ala Asn Arg Leu  Ala Asp Glu 
    1835                 1840                 1845             


Ile Asn  Ser Ile Ile Asp Tyr  Val Glu Asp Ile Gln  Thr Lys Leu 
    1850                 1855                 1860             


Pro Pro  Met Ser Glu Glu Leu  Asn Asp Lys Ile Asp  Asp Leu Ser 
    1865                 1870                 1875             


Gln Glu  Ile Lys Asp Arg Lys  Leu Ala Glu Lys Val  Ser Gln Ala 
    1880                 1885                 1890             


Glu Ser  His Ala Ala Gln Leu  Asn Asp Ser Ser Ala  Val Leu Asp 
    1895                 1900                 1905             


Gly Ile  Leu Asp Glu Ala Lys  Asn Ile Ser Phe Asn  Ala Thr Ala 
    1910                 1915                 1920             


Ala Phe  Lys Ala Tyr Ser Asn  Ile Lys Asp Tyr Ile  Asp Glu Ala 
    1925                 1930                 1935             


Glu Lys  Val Ala Lys Glu Ala  Lys Asp Leu Ala His  Glu Ala Thr 
    1940                 1945                 1950             


Lys Leu  Ala Thr Gly Pro Arg  Gly Leu Leu Lys Glu  Asp Ala Lys 
    1955                 1960                 1965             


Gly Cys  Leu Gln Lys Ser Phe  Arg Ile Leu Asn Glu  Ala Lys Lys 
    1970                 1975                 1980             


Leu Ala  Asn Asp Val Lys Glu  Asn Glu Asp His Leu  Asn Gly Leu 
    1985                 1990                 1995             


Lys Thr  Arg Ile Glu Asn Ala  Asp Ala Arg Asn Gly  Asp Leu Leu 
    2000                 2005                 2010             


Arg Thr  Leu Asn Asp Thr Leu  Gly Lys Leu Ser Ala  Ile Pro Asn 
    2015                 2020                 2025             


Asp Thr  Ala Ala Lys Leu Gln  Ala Val Lys Asp Lys  Ala Arg Gln 
    2030                 2035                 2040             


Ala Asn  Asp Thr Ala Lys Asp  Val Leu Ala Gln Ile  Thr Glu Leu 
    2045                 2050                 2055             


His Gln  Asn Leu Asp Gly Leu  Lys Lys Asn Tyr Asn  Lys Leu Ala 
    2060                 2065                 2070             


Asp Ser  Val Ala Lys Thr Asn  Ala Val Val Lys Asp  Pro Ser Lys 
    2075                 2080                 2085             


Asn Lys  Ile Ile Ala Asp Ala  Asp Ala Thr Val Lys  Asn Leu Glu 
    2090                 2095                 2100             


Gln Glu  Ala Asp Arg Leu Ile  Asp Lys Leu Lys Pro  Ile Lys Glu 
    2105                 2110                 2115             


Leu Glu  Asp Asn Leu Lys Lys  Asn Ile Ser Glu Ile  Lys Glu Leu 
    2120                 2125                 2130             


Ile Asn  Gln Ala Arg Lys Gln  Ala Asn Ser Ile Lys  Val Ser Val 
    2135                 2140                 2145             


Ser Ser  Gly Gly Asp Cys Ile  Arg Thr Tyr Lys Pro  Glu Ile Lys 
    2150                 2155                 2160             


Lys Gly  Ser Tyr Asn Asn Ile  Val Val Asn Val Lys  Thr Ala Val 
    2165                 2170                 2175             


Ala Asp  Asn Leu Leu Phe Tyr  Leu Gly Ser Ala Lys  Phe Ile Asp 
    2180                 2185                 2190             


Phe Leu  Ala Ile Glu Met Arg  Lys Gly Lys Val Ser  Phe Leu Trp 
    2195                 2200                 2205             


Asp Val  Gly Ser Gly Val Gly  Arg Val Glu Tyr Pro  Asp Leu Thr 
    2210                 2215                 2220             


Ile Asp  Asp Ser Tyr Trp Tyr  Arg Ile Val Ala Ser  Arg Thr Gly 
    2225                 2230                 2235             


Arg Asn  Gly Thr Ile Ser Val  Arg Ala Leu Asp Gly  Pro Lys Ala 
    2240                 2245                 2250             


Ser Ile  Val Pro Ser Thr His  His Ser Thr Ser Pro  Pro Gly Tyr 
    2255                 2260                 2265             


Thr Ile  Leu Asp Val Asp Ala  Asn Ala Met Leu Phe  Val Gly Gly 
    2270                 2275                 2280             


Leu Thr  Gly Lys Leu Lys Lys  Ala Asp Ala Val Arg  Val Ile Thr 
    2285                 2290                 2295             


Phe Thr  Gly Cys Met Gly Glu  Thr Tyr Phe Asp Asn  Lys Pro Ile 
    2300                 2305                 2310             


Gly Leu  Trp Asn Phe Arg Glu  Lys Glu Gly Asp Cys  Lys Gly Cys 
    2315                 2320                 2325             


Thr Val  Ser Pro Gln Val Glu  Asp Ser Glu Gly Thr  Ile Gln Phe 
    2330                 2335                 2340             


Asp Gly  Glu Gly Tyr Ala Leu  Val Ser Arg Pro Ile  Arg Trp Tyr 
    2345                 2350                 2355             


Pro Asn  Ile Ser Thr Val Met  Phe Lys Phe Arg Thr  Phe Ser Ser 
    2360                 2365                 2370             


Ser Ala  Leu Leu Met Tyr Leu  Ala Thr Arg Asp Leu  Arg Asp Phe 
    2375                 2380                 2385             


Met Ser  Val Glu Leu Thr Asp  Gly His Ile Lys Val  Ser Tyr Asp 
    2390                 2395                 2400             


Leu Gly  Ser Gly Met Ala Ser  Val Val Ser Asn Gln  Asn His Asn 
    2405                 2410                 2415             


Asp Gly  Lys Trp Lys Ser Phe  Thr Leu Ser Arg Ile  Gln Lys Gln 
    2420                 2425                 2430             


Ala Asn  Ile Ser Ile Val Asp  Ile Asp Thr Asn Gln  Glu Glu Asn 
    2435                 2440                 2445             


Ile Ala  Thr Ser Ser Ser Gly  Asn Asn Phe Gly Leu  Asp Leu Lys 
    2450                 2455                 2460             


Ala Asp  Asp Lys Ile Tyr Phe  Gly Gly Leu Pro Thr  Leu Arg Asn 
    2465                 2470                 2475             


Leu Ser  Met Lys Ala Arg Pro  Glu Val Asn Leu Lys  Lys Tyr Ser 
    2480                 2485                 2490             


Gly Cys  Leu Lys Asp Ile Glu  Ile Ser Arg Thr Pro  Tyr Asn Ile 
    2495                 2500                 2505             


Leu Ser  Ser Pro Asp Tyr Val  Gly Val Thr Lys Gly  Cys Ser Leu 
    2510                 2515                 2520             


Glu Asn  Val Tyr Thr Val Ser  Phe Pro Lys Pro Gly  Phe Val Glu 
    2525                 2530                 2535             


Leu Ser  Pro Val Pro Ile Asp  Val Gly Thr Glu Ile  Asn Leu Ser 
    2540                 2545                 2550             


Phe Ser  Thr Lys Asn Glu Ser  Gly Ile Ile Leu Leu  Gly Ser Gly 
    2555                 2560                 2565             


Gly Thr  Pro Ala Pro Pro Arg  Arg Lys Arg Arg Gln  Thr Gly Gln 
    2570                 2575                 2580             


Ala Tyr  Tyr Ala Ile Leu Leu  Asn Arg Gly Arg Leu  Glu Val His 
    2585                 2590                 2595             


Leu Ser  Thr Gly Ala Arg Thr  Met Arg Lys Ile Val  Ile Arg Pro 
    2600                 2605                 2610             


Glu Pro  Asn Leu Phe His Asp  Gly Arg Glu His Ser  Val His Val 
    2615                 2620                 2625             


Glu Arg  Thr Arg Gly Ile Phe  Thr Val Gln Val Asp  Glu Asn Arg 
    2630                 2635                 2640             


Arg Tyr  Met Gln Asn Leu Thr  Val Glu Gln Pro Ile  Glu Val Lys 
    2645                 2650                 2655             


Lys Leu  Phe Val Gly Gly Ala  Pro Pro Glu Phe Gln  Pro Ser Pro 
    2660                 2665                 2670             


Leu Arg  Asn Ile Pro Pro Phe  Glu Gly Cys Ile Trp  Asn Leu Val 
    2675                 2680                 2685             


Ile Asn  Ser Val Pro Met Asp  Phe Ala Arg Pro Val  Ser Phe Lys 
    2690                 2695                 2700             


Asn Ala  Asp Ile Gly Arg Cys  Ala His Gln Lys Leu  Arg Glu Asp 
    2705                 2710                 2715             


Glu Asp  Gly Ala Ala Pro Ala  Glu Ile Val Ile Gln  Pro Glu Pro 
    2720                 2725                 2730             


Val Pro  Thr Pro Ala Phe Pro  Thr Pro Thr Pro Val  Leu Thr His 
    2735                 2740                 2745             


Gly Pro  Cys Ala Ala Glu Ser  Glu Pro Ala Leu Leu  Ile Gly Ser 
    2750                 2755                 2760             


Lys Gln  Phe Gly Leu Ser Arg  Asn Ser His Ile Ala  Ile Ala Phe 
    2765                 2770                 2775             


Asp Asp  Thr Lys Val Lys Asn  Arg Leu Thr Ile Glu  Leu Glu Val 
    2780                 2785                 2790             


Arg Thr  Glu Ala Glu Ser Gly  Leu Leu Phe Tyr Met  Ala Arg Ile 
    2795                 2800                 2805             


Asn His  Ala Asp Phe Ala Thr  Val Gln Leu Arg Asn  Gly Leu Pro 
    2810                 2815                 2820             


Tyr Phe  Ser Tyr Asp Leu Gly  Ser Gly Asp Thr His  Thr Met Ile 
    2825                 2830                 2835             


Pro Thr  Lys Ile Asn Asp Gly  Gln Trp His Lys Ile  Lys Ile Met 
    2840                 2845                 2850             


Arg Ser  Lys Gln Glu Gly Ile  Leu Tyr Val Asp Gly  Ala Ser Asn 
    2855                 2860                 2865             


Arg Thr  Ile Ser Pro Lys Lys  Ala Asp Ile Leu Asp  Val Val Gly 
    2870                 2875                 2880             


Met Leu  Tyr Val Gly Gly Leu  Pro Ile Asn Tyr Thr  Thr Arg Arg 
    2885                 2890                 2895             


Ile Gly  Pro Val Thr Tyr Ser  Ile Asp Gly Cys Val  Arg Asn Leu 
    2900                 2905                 2910             


His Met  Ala Glu Ala Pro Ala  Asp Leu Glu Gln Pro  Thr Ser Ser 
    2915                 2920                 2925             


Phe His  Val Gly Thr Cys Phe  Ala Asn Ala Gln Arg  Gly Thr Tyr 
    2930                 2935                 2940             


Phe Asp  Gly Thr Gly Phe Ala  Lys Ala Val Gly Gly  Phe Lys Val 
    2945                 2950                 2955             


Gly Leu  Asp Leu Leu Val Glu  Phe Glu Phe Arg Thr  Thr Thr Thr 
    2960                 2965                 2970             


Thr Gly  Val Leu Leu Gly Ile  Ser Ser Gln Lys Met  Asp Gly Met 
    2975                 2980                 2985             


Gly Ile  Glu Met Ile Asp Glu  Lys Leu Met Phe His  Val Asp Asn 
    2990                 2995                 3000             


Gly Ala  Gly Arg Phe Thr Ala  Val Tyr Asp Ala Gly  Val Pro Gly 
    3005                 3010                 3015             


His Leu  Cys Asp Gly Gln Trp  His Lys Val Thr Ala  Asn Lys Ile 
    3020                 3025                 3030             


Lys His  Arg Ile Glu Leu Thr  Val Asp Gly Asn Gln  Val Glu Ala 
    3035                 3040                 3045             


Gln Ser  Pro Asn Pro Ala Ser  Thr Ser Ala Asp Thr  Asn Asp Pro 
    3050                 3055                 3060             


Val Phe  Val Gly Gly Phe Pro  Asp Asp Leu Lys Gln  Phe Gly Leu 
    3065                 3070                 3075             


Thr Thr  Ser Ile Pro Phe Arg  Gly Cys Ile Arg Ser  Leu Lys Leu 
    3080                 3085                 3090             


Thr Lys  Gly Thr Gly Lys Pro  Leu Glu Val Asn Phe  Ala Lys Ala 
    3095                 3100                 3105             


Leu Glu  Leu Arg Gly Val Gln  Pro Val Ser Cys Pro  Ala Asn 
    3110                 3115                 3120         


<210>  7644
<211>  3121
<212>  PRT
<213>  Homo Sapiens

<400>  7644

Met Pro Gly Ala Ala Gly Val Leu Leu Leu Leu Leu Leu Ser Gly Gly 
1               5                   10                  15      


Leu Gly Gly Val Gln Ala Gln Arg Pro Gln Gln Gln Arg Gln Ser Gln 
            20                  25                  30          


Ala His Gln Gln Arg Gly Leu Phe Pro Ala Val Leu Asn Leu Ala Ser 
        35                  40                  45              


Asn Ala Leu Ile Thr Thr Asn Ala Thr Cys Gly Glu Lys Gly Pro Glu 
    50                  55                  60                  


Met Tyr Cys Lys Leu Val Glu His Val Pro Gly Gln Pro Val Arg Asn 
65                  70                  75                  80  


Pro Gln Cys Arg Ile Cys Asn Gln Asn Ser Ser Asn Pro Asn Gln Arg 
                85                  90                  95      


His Pro Ile Thr Asn Ala Ile Asp Gly Lys Asn Thr Trp Trp Gln Ser 
            100                 105                 110         


Pro Ser Ile Lys Asn Gly Ile Glu Tyr His Tyr Val Thr Ile Thr Leu 
        115                 120                 125             


Asp Leu Gln Gln Val Phe Gln Ile Ala Tyr Val Ile Val Lys Ala Ala 
    130                 135                 140                 


Asn Ser Pro Arg Pro Gly Asn Trp Ile Leu Glu Arg Ser Leu Asp Asp 
145                 150                 155                 160 


Val Glu Tyr Lys Pro Trp Gln Tyr His Ala Val Thr Asp Thr Glu Cys 
                165                 170                 175     


Leu Thr Leu Tyr Asn Ile Tyr Pro Arg Thr Gly Pro Pro Ser Tyr Ala 
            180                 185                 190         


Lys Asp Asp Glu Val Ile Cys Thr Ser Phe Tyr Ser Lys Ile His Pro 
        195                 200                 205             


Leu Glu Asn Gly Glu Ile His Ile Ser Leu Ile Asn Gly Arg Pro Ser 
    210                 215                 220                 


Ala Asp Asp Pro Ser Pro Glu Leu Leu Glu Phe Thr Ser Ala Arg Tyr 
225                 230                 235                 240 


Ile Arg Leu Arg Phe Gln Arg Ile Arg Thr Leu Asn Ala Asp Leu Met 
                245                 250                 255     


Met Phe Ala His Lys Asp Pro Arg Glu Ile Asp Pro Ile Val Thr Arg 
            260                 265                 270         


Arg Tyr Tyr Tyr Ser Val Lys Asp Ile Ser Val Gly Gly Met Cys Ile 
        275                 280                 285             


Cys Tyr Gly His Ala Arg Ala Cys Pro Leu Asp Pro Ala Thr Asn Lys 
    290                 295                 300                 


Ser Arg Cys Glu Cys Glu His Asn Thr Cys Gly Asp Ser Cys Asp Gln 
305                 310                 315                 320 


Cys Cys Pro Gly Phe His Gln Lys Pro Trp Arg Ala Gly Thr Phe Leu 
                325                 330                 335     


Thr Lys Thr Glu Cys Glu Ala Cys Asn Cys His Gly Lys Ala Glu Glu 
            340                 345                 350         


Cys Tyr Tyr Asp Glu Asn Val Ala Arg Arg Asn Leu Ser Leu Asn Ile 
        355                 360                 365             


Arg Gly Lys Tyr Ile Gly Gly Gly Val Cys Ile Asn Cys Thr Gln Asn 
    370                 375                 380                 


Thr Ala Gly Ile Asn Cys Glu Thr Cys Thr Asp Gly Phe Phe Arg Pro 
385                 390                 395                 400 


Lys Gly Val Ser Pro Asn Tyr Pro Arg Pro Cys Gln Pro Cys His Cys 
                405                 410                 415     


Asp Pro Ile Gly Ser Leu Asn Glu Val Cys Val Lys Asp Glu Lys His 
            420                 425                 430         


Ala Arg Arg Gly Leu Ala Pro Gly Ser Cys His Cys Lys Thr Gly Phe 
        435                 440                 445             


Gly Gly Val Ser Cys Asp Arg Cys Ala Arg Gly Tyr Thr Gly Tyr Pro 
    450                 455                 460                 


Asp Cys Lys Ala Cys Asn Cys Ser Gly Leu Gly Ser Lys Asn Glu Asp 
465                 470                 475                 480 


Pro Cys Phe Gly Pro Cys Ile Cys Lys Glu Asn Val Glu Gly Gly Asp 
                485                 490                 495     


Cys Ser Arg Cys Lys Ser Gly Phe Phe Asn Leu Gln Glu Asp Asn Trp 
            500                 505                 510         


Lys Gly Cys Asp Glu Cys Phe Cys Ser Gly Val Ser Asn Arg Cys Gln 
        515                 520                 525             


Ser Ser Tyr Trp Thr Tyr Gly Lys Ile Gln Asp Met Ser Gly Trp Tyr 
    530                 535                 540                 


Leu Thr Asp Leu Pro Gly Arg Ile Arg Val Ala Pro Gln Gln Asp Asp 
545                 550                 555                 560 


Leu Asp Ser Pro Gln Gln Ile Ser Ile Ser Asn Ala Glu Ala Arg Gln 
                565                 570                 575     


Ala Leu Pro His Ser Tyr Tyr Trp Ser Ala Pro Ala Pro Tyr Leu Gly 
            580                 585                 590         


Asn Lys Leu Pro Ala Val Gly Gly Gln Leu Thr Phe Thr Ile Ser Tyr 
        595                 600                 605             


Asp Leu Glu Glu Glu Glu Glu Asp Thr Glu Arg Val Leu Gln Leu Met 
    610                 615                 620                 


Ile Ile Leu Glu Gly Asn Asp Leu Ser Ile Ser Thr Ala Gln Asp Glu 
625                 630                 635                 640 


Val Tyr Leu His Pro Ser Glu Glu His Thr Asn Val Leu Leu Leu Lys 
                645                 650                 655     


Glu Glu Ser Phe Thr Ile His Gly Thr His Phe Pro Val Arg Arg Lys 
            660                 665                 670         


Glu Phe Met Thr Val Leu Ala Asn Leu Lys Arg Val Leu Leu Gln Ile 
        675                 680                 685             


Thr Tyr Ser Phe Gly Met Asp Ala Ile Phe Arg Leu Ser Ser Val Asn 
    690                 695                 700                 


Leu Glu Ser Ala Val Ser Tyr Pro Thr Asp Gly Ser Ile Ala Ala Ala 
705                 710                 715                 720 


Val Glu Val Cys Gln Cys Pro Pro Gly Tyr Thr Gly Ser Ser Cys Glu 
                725                 730                 735     


Ser Cys Trp Pro Arg His Arg Arg Val Asn Gly Thr Ile Phe Gly Gly 
            740                 745                 750         


Ile Cys Glu Pro Cys Gln Cys Phe Gly His Ala Glu Ser Cys Asp Asp 
        755                 760                 765             


Val Thr Gly Glu Cys Leu Asn Cys Lys Asp His Thr Gly Gly Pro Tyr 
    770                 775                 780                 


Cys Asp Lys Cys Leu Pro Gly Phe Tyr Gly Glu Pro Thr Lys Gly Thr 
785                 790                 795                 800 


Ser Glu Asp Cys Gln Pro Cys Ala Cys Pro Leu Asn Ile Pro Ser Asn 
                805                 810                 815     


Asn Phe Ser Pro Thr Cys His Leu Asp Arg Ser Leu Gly Leu Ile Cys 
            820                 825                 830         


Asp Gly Cys Pro Val Gly Tyr Thr Gly Pro Arg Cys Glu Arg Cys Ala 
        835                 840                 845             


Glu Gly Tyr Phe Gly Gln Pro Ser Val Pro Gly Gly Ser Cys Gln Pro 
    850                 855                 860                 


Cys Gln Cys Asn Asp Asn Leu Asp Phe Ser Ile Pro Gly Ser Cys Asp 
865                 870                 875                 880 


Ser Leu Ser Gly Ser Cys Leu Ile Cys Lys Pro Gly Thr Thr Gly Arg 
                885                 890                 895     


Tyr Cys Glu Leu Cys Ala Asp Gly Tyr Phe Gly Asp Ala Val Asp Ala 
            900                 905                 910         


Lys Asn Cys Gln Pro Cys Arg Cys Asn Ala Gly Gly Ser Phe Ser Glu 
        915                 920                 925             


Val Cys His Ser Gln Thr Gly Gln Cys Glu Cys Arg Ala Asn Val Gln 
    930                 935                 940                 


Gly Gln Arg Cys Asp Lys Cys Lys Ala Gly Thr Phe Gly Leu Gln Ser 
945                 950                 955                 960 


Ala Arg Gly Cys Val Pro Cys Asn Cys Asn Ser Phe Gly Ser Lys Ser 
                965                 970                 975     


Phe Asp Cys Glu Glu Ser Gly Gln Cys Trp Cys Gln Pro Gly Val Thr 
            980                 985                 990         


Gly Lys Lys Cys Asp Arg Cys Ala  His Gly Tyr Phe Asn  Phe Gln Glu 
        995                 1000                 1005             


Gly Gly  Cys Thr Ala Cys Glu  Cys Ser His Leu Gly  Asn Asn Cys 
    1010                 1015                 1020             


Asp Pro  Lys Thr Gly Arg Cys  Ile Cys Pro Pro Asn  Thr Ile Gly 
    1025                 1030                 1035             


Glu Lys  Cys Ser Lys Cys Ala  Pro Asn Thr Trp Gly  His Ser Ile 
    1040                 1045                 1050             


Thr Thr  Gly Cys Lys Ala Cys  Asn Cys Ser Thr Val  Gly Ser Leu 
    1055                 1060                 1065             


Asp Phe  Gln Cys Asn Val Asn  Thr Gly Gln Cys Asn  Cys His Pro 
    1070                 1075                 1080             


Lys Phe  Ser Gly Ala Lys Cys  Thr Glu Cys Ser Arg  Gly His Trp 
    1085                 1090                 1095             


Asn Tyr  Pro Arg Cys Asn Leu  Cys Asp Cys Phe Leu  Pro Gly Thr 
    1100                 1105                 1110             


Asp Ala  Thr Thr Cys Asp Ser  Glu Thr Lys Lys Cys  Ser Cys Ser 
    1115                 1120                 1125             


Asp Gln  Thr Gly Gln Cys Thr  Cys Lys Val Asn Val  Glu Gly Ile 
    1130                 1135                 1140             


His Cys  Asp Arg Cys Arg Pro  Gly Lys Phe Gly Leu  Asp Ala Lys 
    1145                 1150                 1155             


Asn Pro  Leu Gly Cys Ser Ser  Cys Tyr Cys Phe Gly  Thr Thr Thr 
    1160                 1165                 1170             


Gln Cys  Ser Glu Ala Lys Gly  Leu Ile Arg Thr Trp  Val Thr Leu 
    1175                 1180                 1185             


Lys Ala  Glu Gln Thr Ile Leu  Pro Leu Val Asp Glu  Ala Leu Gln 
    1190                 1195                 1200             


His Thr  Thr Thr Lys Gly Ile  Val Phe Gln His Pro  Glu Ile Val 
    1205                 1210                 1215             


Ala His  Met Asp Leu Met Arg  Glu Asp Leu His Leu  Glu Pro Phe 
    1220                 1225                 1230             


Tyr Trp  Lys Leu Pro Glu Gln  Phe Glu Gly Lys Lys  Leu Met Ala 
    1235                 1240                 1245             


Tyr Gly  Gly Lys Leu Lys Tyr  Ala Ile Tyr Phe Glu  Ala Arg Glu 
    1250                 1255                 1260             


Glu Thr  Gly Phe Ser Thr Tyr  Asn Pro Gln Val Ile  Ile Arg Gly 
    1265                 1270                 1275             


Gly Thr  Pro Thr His Ala Arg  Ile Ile Val Arg His  Met Ala Ala 
    1280                 1285                 1290             


Pro Leu  Ile Gly Gln Leu Thr  Arg His Glu Ile Glu  Met Thr Glu 
    1295                 1300                 1305             


Lys Glu  Trp Lys Tyr Tyr Gly  Asp Asp Pro Arg Val  His Arg Thr 
    1310                 1315                 1320             


Val Thr  Arg Glu Asp Phe Leu  Asp Ile Leu Tyr Asp  Ile His Tyr 
    1325                 1330                 1335             


Ile Leu  Ile Lys Ala Thr Tyr  Gly Asn Phe Met Arg  Gln Ser Arg 
    1340                 1345                 1350             


Ile Ser  Glu Ile Ser Met Glu  Val Ala Glu Gln Gly  Arg Gly Thr 
    1355                 1360                 1365             


Thr Met  Thr Pro Pro Ala Asp  Leu Ile Glu Lys Cys  Asp Cys Pro 
    1370                 1375                 1380             


Leu Gly  Tyr Ser Gly Leu Ser  Cys Glu Ala Cys Leu  Pro Gly Phe 
    1385                 1390                 1395             


Tyr Arg  Leu Arg Ser Gln Pro  Gly Gly Arg Thr Pro  Gly Pro Thr 
    1400                 1405                 1410             


Leu Gly  Thr Cys Val Pro Cys  Gln Cys Asn Gly His  Ser Ser Leu 
    1415                 1420                 1425             


Cys Asp  Pro Glu Thr Ser Ile  Cys Gln Asn Cys Gln  His His Thr 
    1430                 1435                 1440             


Ala Gly  Asp Phe Cys Glu Arg  Cys Ala Leu Gly Tyr  Tyr Gly Ile 
    1445                 1450                 1455             


Val Lys  Gly Leu Pro Asn Asp  Cys Gln Gln Cys Ala  Cys Pro Leu 
    1460                 1465                 1470             


Ile Ser  Ser Ser Asn Asn Phe  Ser Pro Ser Cys Val  Ala Glu Gly 
    1475                 1480                 1485             


Leu Asp  Asp Tyr Arg Cys Thr  Ala Cys Pro Arg Gly  Tyr Glu Gly 
    1490                 1495                 1500             


Gln Tyr  Cys Glu Arg Cys Ala  Pro Gly Tyr Thr Gly  Ser Pro Gly 
    1505                 1510                 1515             


Asn Pro  Gly Gly Ser Cys Gln  Glu Cys Glu Cys Asp  Pro Tyr Gly 
    1520                 1525                 1530             


Ser Leu  Pro Val Pro Cys Asp  Pro Val Thr Gly Phe  Cys Thr Cys 
    1535                 1540                 1545             


Arg Pro  Gly Ala Thr Gly Arg  Lys Cys Asp Gly Cys  Lys His Trp 
    1550                 1555                 1560             


His Ala  Arg Glu Gly Trp Glu  Cys Val Phe Cys Gly  Asp Glu Cys 
    1565                 1570                 1575             


Thr Gly  Leu Leu Leu Gly Asp  Leu Ala Arg Leu Glu  Gln Met Val 
    1580                 1585                 1590             


Met Ser  Ile Asn Leu Thr Gly  Pro Leu Pro Ala Pro  Tyr Lys Met 
    1595                 1600                 1605             


Leu Tyr  Gly Leu Glu Asn Met  Thr Gln Glu Leu Lys  His Leu Leu 
    1610                 1615                 1620             


Ser Pro  Gln Arg Ala Pro Glu  Arg Leu Ile Gln Leu  Ala Glu Gly 
    1625                 1630                 1635             


Asn Leu  Asn Thr Leu Val Thr  Glu Met Asn Glu Leu  Leu Thr Arg 
    1640                 1645                 1650             


Ala Thr  Lys Val Thr Ala Asp  Gly Glu Gln Thr Gly  Gln Asp Ala 
    1655                 1660                 1665             


Glu Arg  Thr Asn Thr Arg Ala  Lys Ser Leu Gly Glu  Phe Ile Lys 
    1670                 1675                 1680             


Glu Leu  Ala Arg Asp Ala Glu  Ala Val Asn Glu Lys  Ala Ile Lys 
    1685                 1690                 1695             


Leu Asn  Glu Thr Leu Gly Thr  Arg Asp Glu Ala Phe  Glu Arg Asn 
    1700                 1705                 1710             


Leu Glu  Gly Leu Gln Lys Glu  Ile Asp Gln Met Ile  Lys Glu Leu 
    1715                 1720                 1725             


Arg Arg  Lys Asn Leu Glu Thr  Gln Lys Glu Ile Ala  Glu Asp Glu 
    1730                 1735                 1740             


Leu Val  Ala Ala Glu Ala Leu  Leu Lys Lys Val Lys  Lys Leu Phe 
    1745                 1750                 1755             


Gly Glu  Ser Arg Gly Glu Asn  Glu Glu Met Glu Lys  Asp Leu Arg 
    1760                 1765                 1770             


Glu Lys  Leu Ala Asp Tyr Lys  Asn Lys Val Asp Asp  Ala Trp Asp 
    1775                 1780                 1785             


Leu Leu  Arg Glu Ala Thr Asp  Lys Ile Arg Glu Ala  Asn Arg Leu 
    1790                 1795                 1800             


Phe Ala  Val Asn Gln Lys Asn  Met Thr Ala Leu Glu  Lys Lys Lys 
    1805                 1810                 1815             


Glu Ala  Val Glu Ser Gly Lys  Arg Gln Ile Glu Asn  Thr Leu Lys 
    1820                 1825                 1830             


Glu Gly  Asn Asp Ile Leu Asp  Glu Ala Asn Arg Leu  Ala Asp Glu 
    1835                 1840                 1845             


Ile Asn  Ser Ile Ile Asp Tyr  Val Glu Asp Ile Gln  Thr Lys Leu 
    1850                 1855                 1860             


Pro Pro  Met Ser Glu Glu Leu  Asn Asp Lys Ile Asp  Asp Leu Ser 
    1865                 1870                 1875             


Gln Glu  Ile Lys Asp Arg Lys  Leu Ala Glu Lys Val  Ser Gln Ala 
    1880                 1885                 1890             


Glu Ser  His Ala Ala Gln Leu  Asn Asp Ser Ser Ala  Val Leu Asp 
    1895                 1900                 1905             


Gly Ile  Leu Asp Glu Ala Lys  Asn Ile Ser Phe Asn  Ala Thr Ala 
    1910                 1915                 1920             


Ala Phe  Lys Ala Tyr Ser Asn  Ile Lys Asp Tyr Ile  Asp Glu Ala 
    1925                 1930                 1935             


Glu Lys  Val Ala Lys Glu Ala  Lys Asp Leu Ala His  Glu Ala Thr 
    1940                 1945                 1950             


Lys Leu  Ala Thr Gly Pro Arg  Gly Leu Leu Lys Glu  Asp Ala Lys 
    1955                 1960                 1965             


Gly Cys  Leu Gln Lys Ser Phe  Arg Ile Leu Asn Glu  Ala Lys Lys 
    1970                 1975                 1980             


Leu Ala  Asn Asp Val Lys Glu  Asn Glu Asp His Leu  Asn Gly Leu 
    1985                 1990                 1995             


Lys Thr  Arg Ile Glu Asn Ala  Asp Ala Arg Asn Gly  Asp Leu Leu 
    2000                 2005                 2010             


Arg Thr  Leu Asn Asp Thr Leu  Gly Lys Leu Ser Ala  Ile Pro Asn 
    2015                 2020                 2025             


Asp Thr  Ala Ala Lys Leu Gln  Ala Val Lys Asp Lys  Ala Arg Gln 
    2030                 2035                 2040             


Ala Asn  Asp Thr Ala Lys Asp  Val Leu Ala Gln Ile  Thr Glu Leu 
    2045                 2050                 2055             


His Gln  Asn Leu Asp Gly Leu  Lys Lys Asn Tyr Asn  Lys Leu Ala 
    2060                 2065                 2070             


Asp Ser  Val Ala Lys Thr Asn  Ala Val Val Lys Asp  Pro Ser Lys 
    2075                 2080                 2085             


Asn Thr  Val Ala Asp Ala Asp  Ala Thr Val Lys Asn  Leu Glu Gln 
    2090                 2095                 2100             


Glu Ala  Asp Arg Leu Ile Asp  Lys Leu Lys Pro Ile  Lys Glu Leu 
    2105                 2110                 2115             


Glu Asp  Asn Leu Lys Lys Asn  Ile Ser Glu Ile Lys  Glu Leu Ile 
    2120                 2125                 2130             


Asn Gln  Ala Arg Lys Gln Ala  Asn Ser Ile Lys Val  Ser Val Ser 
    2135                 2140                 2145             


Ser Gly  Gly Asp Cys Ile Arg  Thr Tyr Lys Pro Glu  Ile Lys Lys 
    2150                 2155                 2160             


Gly Ser  Tyr Asn Asn Ile Val  Val Asn Val Lys Thr  Ala Val Ala 
    2165                 2170                 2175             


Asp Asn  Leu Leu Phe Tyr Leu  Gly Ser Ala Lys Phe  Ile Asp Phe 
    2180                 2185                 2190             


Leu Ala  Ile Glu Met Arg Lys  Gly Lys Val Ser Phe  Leu Trp Asp 
    2195                 2200                 2205             


Val Gly  Ser Gly Val Gly Arg  Val Glu Tyr Pro Asp  Leu Thr Ile 
    2210                 2215                 2220             


Asp Asp  Ser Tyr Trp Tyr Arg  Ile Val Ala Ser Arg  Thr Gly Arg 
    2225                 2230                 2235             


Asn Gly  Thr Ile Ser Val Arg  Ala Leu Asp Gly Pro  Lys Ala Ser 
    2240                 2245                 2250             


Ile Val  Pro Ser Thr His His  Ser Thr Ser Pro Pro  Gly Tyr Thr 
    2255                 2260                 2265             


Ile Leu  Asp Val Asp Ala Asn  Ala Met Leu Phe Val  Gly Gly Leu 
    2270                 2275                 2280             


Thr Gly  Lys Leu Lys Lys Ala  Asp Ala Val Arg Val  Ile Thr Phe 
    2285                 2290                 2295             


Thr Gly  Cys Met Gly Glu Thr  Tyr Phe Asp Asn Lys  Pro Ile Gly 
    2300                 2305                 2310             


Leu Trp  Asn Phe Arg Glu Lys  Glu Gly Asp Cys Lys  Gly Cys Thr 
    2315                 2320                 2325             


Val Ser  Pro Gln Val Glu Asp  Ser Glu Gly Thr Ile  Gln Phe Asp 
    2330                 2335                 2340             


Gly Glu  Gly Tyr Ala Leu Val  Ser Arg Pro Ile Arg  Trp Tyr Pro 
    2345                 2350                 2355             


Asn Ile  Ser Thr Val Met Phe  Lys Phe Arg Thr Phe  Ser Ser Ser 
    2360                 2365                 2370             


Ala Leu  Leu Met Tyr Leu Ala  Thr Arg Asp Leu Arg  Asp Phe Met 
    2375                 2380                 2385             


Ser Val  Glu Leu Thr Asp Gly  His Ile Lys Val Ser  Tyr Asp Leu 
    2390                 2395                 2400             


Gly Ser  Gly Met Ala Ser Val  Val Ser Asn Gln Asn  His Asn Asp 
    2405                 2410                 2415             


Gly Lys  Trp Lys Ser Phe Thr  Leu Ser Arg Ile Gln  Lys Gln Ala 
    2420                 2425                 2430             


Asn Ile  Ser Ile Val Asp Ile  Asp Thr Asn Gln Glu  Glu Asn Ile 
    2435                 2440                 2445             


Ala Thr  Ser Ser Ser Gly Asn  Asn Phe Gly Leu Asp  Leu Lys Ala 
    2450                 2455                 2460             


Asp Asp  Lys Ile Tyr Phe Gly  Gly Leu Pro Thr Leu  Arg Asn Leu 
    2465                 2470                 2475             


Ser Met  Lys Ala Arg Pro Glu  Val Asn Leu Lys Lys  Tyr Ser Gly 
    2480                 2485                 2490             


Cys Leu  Lys Asp Ile Glu Ile  Ser Arg Thr Pro Tyr  Asn Ile Leu 
    2495                 2500                 2505             


Ser Ser  Pro Asp Tyr Val Gly  Val Thr Lys Gly Cys  Ser Leu Glu 
    2510                 2515                 2520             


Asn Val  Tyr Thr Val Ser Phe  Pro Lys Pro Gly Phe  Val Glu Leu 
    2525                 2530                 2535             


Ser Pro  Val Pro Ile Asp Val  Gly Thr Glu Ile Asn  Leu Ser Phe 
    2540                 2545                 2550             


Ser Thr  Lys Asn Glu Ser Gly  Ile Ile Leu Leu Gly  Ser Gly Gly 
    2555                 2560                 2565             


Thr Pro  Ala Pro Pro Arg Arg  Lys Arg Arg Gln Thr  Gly Gln Ala 
    2570                 2575                 2580             


Tyr Tyr  Ala Ile Leu Leu Asn  Arg Gly Arg Leu Glu  Val His Leu 
    2585                 2590                 2595             


Ser Thr  Gly Ala Arg Thr Met  Arg Lys Ile Val Ile  Arg Pro Glu 
    2600                 2605                 2610             


Pro Asn  Leu Phe His Asp Gly  Arg Glu His Ser Val  His Val Glu 
    2615                 2620                 2625             


Arg Thr  Arg Gly Ile Phe Thr  Val Gln Val Asp Glu  Asn Arg Arg 
    2630                 2635                 2640             


Tyr Met  Gln Asn Leu Thr Val  Glu Gln Pro Ile Glu  Val Lys Lys 
    2645                 2650                 2655             


Leu Phe  Val Gly Gly Ala Pro  Pro Glu Phe Gln Pro  Ser Pro Leu 
    2660                 2665                 2670             


Arg Asn  Ile Pro Pro Phe Glu  Gly Cys Ile Trp Asn  Leu Val Ile 
    2675                 2680                 2685             


Asn Ser  Val Pro Met Asp Phe  Ala Arg Pro Val Ser  Phe Lys Asn 
    2690                 2695                 2700             


Ala Asp  Ile Gly Arg Cys Ala  His Gln Lys Leu Arg  Glu Asp Glu 
    2705                 2710                 2715             


Asp Gly  Ala Ala Pro Ala Glu  Ile Val Ile Gln Pro  Glu Pro Val 
    2720                 2725                 2730             


Pro Thr  Pro Ala Phe Pro Thr  Pro Thr Pro Val Leu  Thr His Gly 
    2735                 2740                 2745             


Pro Cys  Ala Ala Glu Ser Glu  Pro Ala Leu Leu Ile  Gly Ser Lys 
    2750                 2755                 2760             


Gln Phe  Gly Leu Ser Arg Asn  Ser His Ile Ala Ile  Ala Phe Asp 
    2765                 2770                 2775             


Asp Thr  Lys Val Lys Asn Arg  Leu Thr Ile Glu Leu  Glu Val Arg 
    2780                 2785                 2790             


Thr Glu  Ala Glu Ser Gly Leu  Leu Phe Tyr Met Ala  Arg Ile Asn 
    2795                 2800                 2805             


His Ala  Asp Phe Ala Thr Val  Gln Leu Arg Asn Gly  Leu Pro Tyr 
    2810                 2815                 2820             


Phe Ser  Tyr Asp Leu Gly Ser  Gly Asp Thr His Thr  Met Ile Pro 
    2825                 2830                 2835             


Thr Lys  Ile Asn Asp Gly Gln  Trp His Lys Ile Lys  Ile Met Arg 
    2840                 2845                 2850             


Ser Lys  Gln Glu Gly Ile Leu  Tyr Val Asp Gly Ala  Ser Asn Arg 
    2855                 2860                 2865             


Thr Ile  Ser Pro Lys Lys Ala  Asp Ile Leu Asp Val  Val Gly Met 
    2870                 2875                 2880             


Leu Tyr  Val Gly Gly Leu Pro  Ile Asn Tyr Thr Thr  Arg Arg Ile 
    2885                 2890                 2895             


Gly Pro  Val Thr Tyr Ser Ile  Asp Gly Cys Val Arg  Asn Leu His 
    2900                 2905                 2910             


Met Ala  Glu Ala Pro Ala Asp  Leu Glu Gln Pro Thr  Ser Ser Phe 
    2915                 2920                 2925             


His Val  Gly Thr Cys Phe Ala  Asn Ala Gln Arg Gly  Thr Tyr Phe 
    2930                 2935                 2940             


Asp Gly  Thr Gly Phe Ala Lys  Ala Val Gly Gly Phe  Lys Val Gly 
    2945                 2950                 2955             


Leu Asp  Leu Leu Val Glu Phe  Glu Phe Arg Thr Thr  Thr Thr Thr 
    2960                 2965                 2970             


Gly Val  Leu Leu Gly Ile Ser  Ser Gln Lys Met Asp  Gly Met Gly 
    2975                 2980                 2985             


Ile Glu  Met Ile Asp Glu Lys  Leu Met Phe His Val  Asp Asn Gly 
    2990                 2995                 3000             


Ala Gly  Arg Phe Thr Ala Val  Tyr Asp Ala Gly Val  Pro Gly His 
    3005                 3010                 3015             


Leu Cys  Asp Gly Gln Trp His  Lys Val Thr Ala Asn  Lys Ile Lys 
    3020                 3025                 3030             


His Arg  Ile Glu Leu Thr Val  Asp Gly Asn Gln Val  Glu Ala Gln 
    3035                 3040                 3045             


Ser Pro  Asn Pro Ala Ser Thr  Ser Ala Asp Thr Asn  Asp Pro Val 
    3050                 3055                 3060             


Phe Val  Gly Gly Phe Pro Asp  Asp Leu Lys Gln Phe  Gly Leu Thr 
    3065                 3070                 3075             


Thr Ser  Ile Pro Phe Arg Gly  Cys Ile Arg Ser Leu  Lys Leu Thr 
    3080                 3085                 3090             


Lys Gly  Thr Gly Lys Pro Leu  Glu Val Asn Phe Ala  Lys Ala Leu 
    3095                 3100                 3105             


Glu Leu  Arg Gly Val Gln Pro  Val Ser Cys Pro Ala  Asn 
    3110                 3115                 3120     


<210>  7645
<211>  3118
<212>  PRT
<213>  Homo Sapiens

<400>  7645

Met Pro Gly Ala Ala Gly Val Leu Leu Leu Leu Leu Leu Ser Gly Gly 
1               5                   10                  15      


Leu Gly Gly Val Gln Ala Gln Arg Pro Gln Gln Gln Arg Gln Ser Gln 
            20                  25                  30          


Ala His Gln Gln Arg Gly Leu Phe Pro Ala Val Leu Asn Leu Ala Ser 
        35                  40                  45              


Asn Ala Leu Ile Thr Thr Asn Ala Thr Cys Gly Glu Lys Gly Pro Glu 
    50                  55                  60                  


Met Tyr Cys Lys Leu Val Glu His Val Pro Gly Gln Pro Val Arg Asn 
65                  70                  75                  80  


Pro Gln Cys Arg Ile Cys Asn Gln Asn Ser Ser Asn Pro Asn Gln Arg 
                85                  90                  95      


His Pro Ile Thr Asn Ala Ile Asp Gly Lys Asn Thr Trp Trp Gln Ser 
            100                 105                 110         


Pro Ser Ile Lys Asn Gly Ile Glu Tyr His Tyr Val Thr Ile Thr Leu 
        115                 120                 125             


Asp Leu Gln Gln Val Phe Gln Ile Ala Tyr Val Ile Val Lys Ala Ala 
    130                 135                 140                 


Asn Ser Pro Arg Pro Gly Asn Trp Ile Leu Glu Arg Ser Leu Asp Asp 
145                 150                 155                 160 


Val Glu Tyr Lys Pro Trp Gln Tyr His Ala Val Thr Asp Thr Glu Cys 
                165                 170                 175     


Leu Thr Leu Tyr Asn Ile Tyr Pro Arg Thr Gly Pro Pro Ser Tyr Ala 
            180                 185                 190         


Lys Asp Asp Glu Val Ile Cys Thr Ser Phe Tyr Ser Lys Ile His Pro 
        195                 200                 205             


Leu Glu Asn Gly Glu Ile His Ile Ser Leu Ile Asn Gly Arg Pro Ser 
    210                 215                 220                 


Ala Asp Asp Pro Ser Pro Glu Leu Leu Glu Phe Thr Ser Ala Arg Tyr 
225                 230                 235                 240 


Ile Arg Leu Arg Phe Gln Arg Ile Arg Thr Leu Asn Ala Asp Leu Met 
                245                 250                 255     


Met Phe Ala His Lys Asp Pro Arg Glu Ile Asp Pro Ile Val Thr Arg 
            260                 265                 270         


Arg Tyr Tyr Tyr Ser Val Lys Asp Ile Ser Val Gly Gly Met Cys Ile 
        275                 280                 285             


Cys Tyr Gly His Ala Arg Ala Cys Pro Leu Asp Pro Ala Thr Asn Lys 
    290                 295                 300                 


Ser Arg Cys Glu Cys Glu His Asn Thr Cys Gly Asp Ser Cys Asp Gln 
305                 310                 315                 320 


Cys Cys Pro Gly Phe His Gln Lys Pro Trp Arg Ala Gly Thr Phe Leu 
                325                 330                 335     


Thr Lys Thr Glu Cys Glu Ala Cys Asn Cys His Gly Lys Ala Glu Glu 
            340                 345                 350         


Cys Tyr Tyr Asp Glu Asn Val Ala Arg Arg Asn Leu Ser Leu Asn Ile 
        355                 360                 365             


Arg Gly Lys Tyr Ile Gly Gly Gly Val Cys Ile Asn Cys Thr Gln Asn 
    370                 375                 380                 


Thr Ala Gly Ile Asn Cys Glu Thr Cys Thr Asp Gly Phe Phe Arg Pro 
385                 390                 395                 400 


Lys Gly Val Ser Pro Asn Tyr Pro Arg Pro Cys Gln Pro Cys His Cys 
                405                 410                 415     


Asp Pro Ile Gly Ser Leu Asn Glu Val Cys Val Lys Asp Glu Lys His 
            420                 425                 430         


Ala Arg Arg Gly Leu Ala Pro Gly Ser Cys His Cys Lys Thr Gly Phe 
        435                 440                 445             


Gly Gly Val Ser Cys Asp Arg Cys Ala Arg Gly Tyr Thr Gly Tyr Pro 
    450                 455                 460                 


Asp Cys Lys Ala Cys Asn Cys Ser Gly Leu Gly Ser Lys Asn Glu Asp 
465                 470                 475                 480 


Pro Cys Phe Gly Pro Cys Ile Cys Lys Glu Asn Val Glu Gly Gly Asp 
                485                 490                 495     


Cys Ser Arg Cys Lys Ser Gly Phe Phe Asn Leu Gln Glu Asp Asn Trp 
            500                 505                 510         


Lys Gly Cys Asp Glu Cys Phe Cys Ser Gly Val Ser Asn Arg Cys Gln 
        515                 520                 525             


Ser Ser Tyr Trp Thr Tyr Gly Lys Ile Gln Asp Met Ser Gly Trp Tyr 
    530                 535                 540                 


Leu Thr Asp Leu Pro Gly Arg Ile Arg Val Ala Pro Gln Gln Asp Asp 
545                 550                 555                 560 


Leu Asp Ser Pro Gln Gln Ile Ser Ile Ser Asn Ala Glu Ala Arg Gln 
                565                 570                 575     


Ala Leu Pro His Ser Tyr Tyr Trp Ser Ala Pro Ala Pro Tyr Leu Gly 
            580                 585                 590         


Asn Lys Leu Pro Ala Val Gly Gly Gln Leu Thr Phe Thr Ile Ser Tyr 
        595                 600                 605             


Asp Leu Glu Glu Glu Glu Glu Asp Thr Glu Arg Val Leu Gln Leu Met 
    610                 615                 620                 


Ile Ile Leu Glu Gly Asn Asp Leu Ser Ile Ser Thr Ala Gln Asp Glu 
625                 630                 635                 640 


Val Tyr Leu His Pro Ser Glu Glu His Thr Asn Val Leu Leu Leu Lys 
                645                 650                 655     


Glu Glu Ser Phe Thr Ile His Gly Thr His Phe Pro Val Arg Arg Lys 
            660                 665                 670         


Glu Phe Met Thr Val Leu Ala Asn Leu Lys Arg Val Leu Leu Gln Ile 
        675                 680                 685             


Thr Tyr Ser Phe Gly Met Asp Ala Ile Phe Arg Leu Ser Ser Val Asn 
    690                 695                 700                 


Leu Glu Ser Ala Val Ser Tyr Pro Thr Asp Gly Ser Ile Ala Ala Ala 
705                 710                 715                 720 


Val Glu Val Cys Gln Cys Pro Pro Gly Tyr Thr Gly Ser Ser Cys Glu 
                725                 730                 735     


Ser Cys Trp Pro Arg His Arg Arg Val Asn Gly Thr Ile Phe Gly Gly 
            740                 745                 750         


Ile Cys Glu Pro Cys Gln Cys Phe Gly His Ala Glu Ser Cys Asp Asp 
        755                 760                 765             


Val Thr Gly Glu Cys Leu Asn Cys Lys Asp His Thr Gly Gly Pro Tyr 
    770                 775                 780                 


Cys Asp Lys Cys Leu Pro Gly Phe Tyr Gly Glu Pro Thr Lys Gly Thr 
785                 790                 795                 800 


Ser Glu Asp Cys Gln Pro Cys Ala Cys Pro Leu Asn Ile Pro Ser Asn 
                805                 810                 815     


Asn Phe Ser Pro Thr Cys His Leu Asp Arg Ser Leu Gly Leu Ile Cys 
            820                 825                 830         


Asp Gly Cys Pro Val Gly Tyr Thr Gly Pro Arg Cys Glu Arg Cys Ala 
        835                 840                 845             


Glu Gly Tyr Phe Gly Gln Pro Ser Val Pro Gly Gly Ser Cys Gln Pro 
    850                 855                 860                 


Cys Gln Cys Asn Asp Asn Leu Asp Phe Ser Ile Pro Gly Ser Cys Asp 
865                 870                 875                 880 


Ser Leu Ser Gly Ser Cys Leu Ile Cys Lys Pro Gly Thr Thr Gly Arg 
                885                 890                 895     


Tyr Cys Glu Leu Cys Ala Asp Gly Tyr Phe Gly Asp Ala Val Asp Ala 
            900                 905                 910         


Lys Asn Cys Gln Pro Cys Arg Cys Asn Ala Gly Gly Ser Phe Ser Glu 
        915                 920                 925             


Val Cys His Ser Gln Thr Gly Gln Cys Glu Cys Arg Ala Asn Val Gln 
    930                 935                 940                 


Gly Gln Arg Cys Asp Lys Cys Lys Ala Gly Thr Phe Gly Leu Gln Ser 
945                 950                 955                 960 


Ala Arg Gly Cys Val Pro Cys Asn Cys Asn Ser Phe Gly Ser Lys Ser 
                965                 970                 975     


Phe Asp Cys Glu Glu Ser Gly Gln Cys Trp Cys Gln Pro Gly Val Thr 
            980                 985                 990         


Gly Lys Lys Cys Asp Arg Cys Ala  His Gly Tyr Phe Asn  Phe Gln Glu 
        995                 1000                 1005             


Gly Gly  Cys Thr Ala Cys Glu  Cys Ser His Leu Gly  Asn Asn Cys 
    1010                 1015                 1020             


Asp Pro  Lys Thr Gly Arg Cys  Ile Cys Pro Pro Asn  Thr Ile Gly 
    1025                 1030                 1035             


Glu Lys  Cys Ser Lys Cys Ala  Pro Asn Thr Trp Gly  His Ser Ile 
    1040                 1045                 1050             


Thr Thr  Gly Cys Lys Ala Cys  Asn Cys Ser Thr Val  Gly Ser Leu 
    1055                 1060                 1065             


Asp Phe  Gln Cys Asn Val Asn  Thr Gly Gln Cys Asn  Cys His Pro 
    1070                 1075                 1080             


Lys Phe  Ser Gly Ala Lys Cys  Thr Glu Cys Ser Arg  Gly His Trp 
    1085                 1090                 1095             


Asn Tyr  Pro Arg Cys Asn Leu  Cys Asp Cys Phe Leu  Pro Gly Thr 
    1100                 1105                 1110             


Asp Ala  Thr Thr Cys Asp Ser  Glu Thr Lys Lys Cys  Ser Cys Ser 
    1115                 1120                 1125             


Asp Gln  Thr Gly Gln Cys Thr  Cys Lys Val Asn Val  Glu Gly Ile 
    1130                 1135                 1140             


His Cys  Asp Arg Cys Arg Pro  Gly Lys Phe Gly Leu  Asp Ala Lys 
    1145                 1150                 1155             


Asn Pro  Leu Gly Cys Ser Ser  Cys Tyr Cys Phe Gly  Thr Thr Thr 
    1160                 1165                 1170             


Gln Cys  Ser Glu Ala Lys Gly  Leu Ile Arg Thr Trp  Val Thr Leu 
    1175                 1180                 1185             


Lys Ala  Glu Gln Thr Ile Leu  Pro Leu Val Asp Glu  Ala Leu Gln 
    1190                 1195                 1200             


His Thr  Thr Thr Lys Gly Ile  Val Phe Gln His Pro  Glu Ile Val 
    1205                 1210                 1215             


Ala His  Met Asp Leu Met Arg  Glu Asp Leu His Leu  Glu Pro Phe 
    1220                 1225                 1230             


Tyr Trp  Lys Leu Pro Glu Gln  Phe Glu Gly Lys Lys  Leu Met Ala 
    1235                 1240                 1245             


Tyr Gly  Gly Lys Leu Lys Tyr  Ala Ile Tyr Phe Glu  Ala Arg Glu 
    1250                 1255                 1260             


Glu Thr  Gly Phe Ser Thr Tyr  Asn Pro Gln Val Ile  Ile Arg Gly 
    1265                 1270                 1275             


Gly Thr  Pro Thr His Ala Arg  Ile Ile Val Arg His  Met Ala Ala 
    1280                 1285                 1290             


Pro Leu  Ile Gly Gln Leu Thr  Arg His Glu Ile Glu  Met Thr Glu 
    1295                 1300                 1305             


Lys Glu  Trp Lys Tyr Tyr Gly  Asp Asp Pro Arg Val  His Arg Thr 
    1310                 1315                 1320             


Val Thr  Arg Glu Asp Phe Leu  Asp Ile Leu Tyr Asp  Ile His Tyr 
    1325                 1330                 1335             


Ile Leu  Ile Lys Ala Thr Tyr  Gly Asn Phe Met Arg  Gln Ser Arg 
    1340                 1345                 1350             


Ile Ser  Glu Ile Ser Met Glu  Val Ala Glu Gln Gly  Arg Gly Thr 
    1355                 1360                 1365             


Thr Met  Thr Pro Pro Ala Asp  Leu Ile Glu Lys Cys  Asp Cys Pro 
    1370                 1375                 1380             


Leu Gly  Tyr Ser Gly Leu Ser  Cys Glu Ala Cys Leu  Pro Gly Phe 
    1385                 1390                 1395             


Tyr Arg  Leu Arg Ser Gln Pro  Gly Gly Arg Thr Pro  Gly Pro Thr 
    1400                 1405                 1410             


Leu Gly  Thr Cys Val Pro Cys  Gln Cys Asn Gly His  Ser Ser Leu 
    1415                 1420                 1425             


Cys Asp  Pro Glu Thr Ser Ile  Cys Gln Asn Cys Gln  His His Thr 
    1430                 1435                 1440             


Ala Gly  Asp Phe Cys Glu Arg  Cys Ala Leu Gly Tyr  Tyr Gly Ile 
    1445                 1450                 1455             


Val Lys  Gly Leu Pro Asn Asp  Cys Gln Gln Cys Ala  Cys Pro Leu 
    1460                 1465                 1470             


Ile Ser  Ser Ser Asn Asn Phe  Ser Pro Ser Cys Val  Ala Glu Gly 
    1475                 1480                 1485             


Leu Asp  Asp Tyr Arg Cys Thr  Ala Cys Pro Arg Gly  Tyr Glu Gly 
    1490                 1495                 1500             


Gln Tyr  Cys Glu Arg Cys Ala  Pro Gly Tyr Thr Gly  Ser Pro Gly 
    1505                 1510                 1515             


Asn Pro  Gly Gly Ser Cys Gln  Glu Cys Glu Cys Asp  Pro Tyr Gly 
    1520                 1525                 1530             


Ser Leu  Pro Val Pro Cys Asp  Pro Val Thr Gly Phe  Cys Thr Cys 
    1535                 1540                 1545             


Arg Pro  Gly Ala Thr Gly Arg  Lys Cys Asp Gly Cys  Lys His Trp 
    1550                 1555                 1560             


His Ala  Arg Glu Gly Trp Glu  Cys Val Phe Cys Gly  Asp Glu Cys 
    1565                 1570                 1575             


Thr Gly  Leu Leu Leu Gly Asp  Leu Ala Arg Leu Glu  Gln Met Val 
    1580                 1585                 1590             


Met Ser  Ile Asn Leu Thr Gly  Pro Leu Pro Ala Pro  Tyr Lys Met 
    1595                 1600                 1605             


Leu Tyr  Gly Leu Glu Asn Met  Thr Gln Glu Leu Lys  His Leu Leu 
    1610                 1615                 1620             


Ser Pro  Gln Arg Ala Pro Glu  Arg Leu Ile Gln Leu  Ala Glu Gly 
    1625                 1630                 1635             


Asn Leu  Asn Thr Leu Val Thr  Glu Met Asn Glu Leu  Leu Thr Arg 
    1640                 1645                 1650             


Ala Thr  Lys Val Thr Ala Asp  Gly Glu Gln Thr Gly  Gln Asp Ala 
    1655                 1660                 1665             


Glu Arg  Thr Asn Thr Arg Ala  Lys Ser Leu Gly Glu  Phe Ile Lys 
    1670                 1675                 1680             


Glu Leu  Ala Arg Asp Ala Glu  Ala Val Asn Glu Lys  Ala Ile Lys 
    1685                 1690                 1695             


Leu Asn  Glu Thr Leu Gly Thr  Arg Asp Glu Ala Phe  Glu Arg Asn 
    1700                 1705                 1710             


Leu Glu  Gly Leu Gln Lys Glu  Ile Asp Gln Met Ile  Lys Glu Leu 
    1715                 1720                 1725             


Arg Arg  Lys Asn Leu Glu Thr  Gln Lys Glu Ile Ala  Glu Asp Glu 
    1730                 1735                 1740             


Leu Val  Ala Ala Glu Ala Leu  Leu Lys Lys Val Lys  Lys Leu Phe 
    1745                 1750                 1755             


Gly Glu  Ser Arg Gly Glu Asn  Glu Glu Met Glu Lys  Asp Leu Arg 
    1760                 1765                 1770             


Glu Lys  Leu Ala Asp Tyr Lys  Asn Lys Val Asp Asp  Ala Trp Asp 
    1775                 1780                 1785             


Leu Leu  Arg Glu Ala Thr Asp  Lys Ile Arg Glu Ala  Asn Arg Leu 
    1790                 1795                 1800             


Phe Ala  Val Asn Gln Lys Asn  Met Thr Ala Leu Glu  Lys Lys Lys 
    1805                 1810                 1815             


Glu Ala  Val Glu Ser Gly Lys  Arg Gln Ile Glu Asn  Thr Leu Lys 
    1820                 1825                 1830             


Glu Gly  Asn Asp Ile Leu Asp  Glu Ala Asn Arg Leu  Ala Asp Glu 
    1835                 1840                 1845             


Ile Asn  Ser Ile Ile Asp Tyr  Val Glu Asp Ile Gln  Thr Lys Leu 
    1850                 1855                 1860             


Pro Pro  Met Ser Glu Glu Leu  Asn Asp Lys Ile Asp  Asp Leu Ser 
    1865                 1870                 1875             


Gln Glu  Ile Lys Asp Arg Lys  Leu Ala Glu Lys Val  Ser Gln Ala 
    1880                 1885                 1890             


Glu Ser  His Ala Ala Gln Leu  Asn Asp Ser Ser Ala  Val Leu Asp 
    1895                 1900                 1905             


Gly Ile  Leu Asp Glu Ala Lys  Asn Ile Ser Phe Asn  Ala Thr Ala 
    1910                 1915                 1920             


Ala Phe  Lys Ala Tyr Ser Asn  Ile Lys Asp Tyr Ile  Asp Glu Ala 
    1925                 1930                 1935             


Glu Lys  Val Ala Lys Glu Ala  Lys Asp Leu Ala His  Glu Ala Thr 
    1940                 1945                 1950             


Lys Leu  Ala Thr Gly Pro Arg  Gly Leu Leu Lys Glu  Asp Ala Lys 
    1955                 1960                 1965             


Gly Cys  Leu Gln Lys Ser Phe  Arg Ile Leu Asn Glu  Ala Lys Lys 
    1970                 1975                 1980             


Leu Ala  Asn Asp Val Lys Glu  Asn Glu Asp His Leu  Asn Gly Leu 
    1985                 1990                 1995             


Lys Thr  Arg Ile Glu Asn Ala  Asp Ala Arg Asn Gly  Asp Leu Leu 
    2000                 2005                 2010             


Arg Thr  Leu Asn Asp Thr Leu  Gly Lys Leu Ser Ala  Ile Pro Asn 
    2015                 2020                 2025             


Asp Thr  Ala Ala Lys Leu Gln  Ala Val Lys Asp Lys  Ala Arg Gln 
    2030                 2035                 2040             


Ala Asn  Asp Thr Ala Lys Asp  Val Leu Ala Gln Ile  Thr Glu Leu 
    2045                 2050                 2055             


His Gln  Asn Leu Asp Gly Leu  Lys Lys Asn Tyr Asn  Lys Leu Ala 
    2060                 2065                 2070             


Asp Ser  Val Ala Lys Thr Asn  Ala Val Val Lys Asp  Pro Ser Lys 
    2075                 2080                 2085             


Asn Asn  Ala Val Ala Asp Ala  Asp Ala Thr Val Lys  Asn Leu Glu 
    2090                 2095                 2100             


Gln Glu  Ala Asp Arg Leu Ile  Asp Lys Leu Lys Pro  Ile Lys Glu 
    2105                 2110                 2115             


Leu Glu  Asp Asn Leu Lys Lys  Asn Ile Ser Glu Ile  Lys Glu Leu 
    2120                 2125                 2130             


Ile Asn  Gln Ala Arg Lys Gln  Ala Asn Ser Ile Lys  Val Ser Val 
    2135                 2140                 2145             


Ser Ser  Gly Gly Asp Cys Ile  Arg Thr Tyr Lys Pro  Glu Ile Lys 
    2150                 2155                 2160             


Lys Gly  Ser Tyr Asn Asn Ile  Val Val Asn Val Lys  Thr Ala Val 
    2165                 2170                 2175             


Ala Asp  Asn Leu Leu Phe Tyr  Leu Gly Ser Ala Lys  Phe Ile Asp 
    2180                 2185                 2190             


Phe Leu  Ala Ile Glu Met Arg  Lys Gly Lys Val Ser  Phe Leu Trp 
    2195                 2200                 2205             


Asp Val  Gly Ser Gly Val Gly  Arg Val Glu Tyr Pro  Asp Leu Thr 
    2210                 2215                 2220             


Ile Asp  Asp Ser Tyr Trp Tyr  Arg Ile Val Ala Ser  Arg Thr Gly 
    2225                 2230                 2235             


Arg Asn  Gly Thr Ile Ser Val  Arg Ala Leu Asp Gly  Pro Lys Ala 
    2240                 2245                 2250             


Ser Ile  Val Pro Ser Thr His  His Ser Thr Ser Pro  Pro Gly Tyr 
    2255                 2260                 2265             


Thr Ile  Leu Asp Val Asp Ala  Asn Ala Met Leu Phe  Val Gly Gly 
    2270                 2275                 2280             


Leu Thr  Gly Lys Leu Lys Lys  Ala Asp Ala Val Arg  Val Ile Thr 
    2285                 2290                 2295             


Phe Thr  Gly Cys Met Gly Glu  Thr Tyr Phe Asp Asn  Lys Pro Ile 
    2300                 2305                 2310             


Gly Leu  Trp Asn Phe Arg Glu  Lys Glu Gly Asp Cys  Lys Gly Cys 
    2315                 2320                 2325             


Thr Val  Ser Pro Gln Val Glu  Asp Ser Glu Gly Thr  Ile Gln Phe 
    2330                 2335                 2340             


Asp Gly  Glu Gly Tyr Ala Leu  Val Ser Arg Pro Ile  Arg Trp Tyr 
    2345                 2350                 2355             


Pro Asn  Ile Ser Thr Val Met  Phe Lys Phe Arg Thr  Phe Ser Ser 
    2360                 2365                 2370             


Ser Ala  Leu Leu Met Tyr Leu  Ala Thr Arg Asp Leu  Arg Asp Phe 
    2375                 2380                 2385             


Met Ser  Val Glu Leu Thr Asp  Gly His Ile Lys Val  Ser Tyr Asp 
    2390                 2395                 2400             


Leu Gly  Ser Gly Met Ala Ser  Val Val Ser Asn Gln  Asn His Asn 
    2405                 2410                 2415             


Asp Gly  Lys Trp Lys Ser Phe  Thr Leu Ser Arg Ile  Gln Lys Gln 
    2420                 2425                 2430             


Ala Asn  Ile Ser Ile Val Asp  Ile Asp Thr Asn Gln  Glu Glu Asn 
    2435                 2440                 2445             


Ile Ala  Thr Ser Ser Ser Gly  Asn Asn Phe Gly Leu  Asp Leu Lys 
    2450                 2455                 2460             


Ala Asp  Asp Lys Ile Tyr Phe  Gly Gly Leu Pro Thr  Leu Arg Asn 
    2465                 2470                 2475             


Leu Arg  Pro Glu Val Asn Leu  Lys Lys Tyr Ser Gly  Cys Leu Lys 
    2480                 2485                 2490             


Asp Ile  Glu Ile Ser Arg Thr  Pro Tyr Asn Ile Leu  Ser Ser Pro 
    2495                 2500                 2505             


Asp Tyr  Val Gly Val Thr Lys  Gly Cys Ser Leu Glu  Asn Val Tyr 
    2510                 2515                 2520             


Thr Val  Ser Phe Pro Lys Pro  Gly Phe Val Glu Leu  Ser Pro Val 
    2525                 2530                 2535             


Pro Ile  Asp Val Gly Thr Glu  Ile Asn Leu Ser Phe  Ser Thr Lys 
    2540                 2545                 2550             


Asn Glu  Ser Gly Ile Ile Leu  Leu Gly Ser Gly Gly  Thr Pro Ala 
    2555                 2560                 2565             


Pro Pro  Arg Arg Lys Arg Arg  Gln Thr Gly Gln Ala  Tyr Tyr Ala 
    2570                 2575                 2580             


Ile Leu  Leu Asn Arg Gly Arg  Leu Glu Val His Leu  Ser Thr Gly 
    2585                 2590                 2595             


Ala Arg  Thr Met Arg Lys Ile  Val Ile Arg Pro Glu  Pro Asn Leu 
    2600                 2605                 2610             


Phe His  Asp Gly Arg Glu His  Ser Val His Val Glu  Arg Thr Arg 
    2615                 2620                 2625             


Gly Ile  Phe Thr Val Gln Val  Asp Glu Asn Arg Arg  Tyr Met Gln 
    2630                 2635                 2640             


Asn Leu  Thr Val Glu Gln Pro  Ile Glu Val Lys Lys  Leu Phe Val 
    2645                 2650                 2655             


Gly Gly  Ala Pro Pro Glu Phe  Gln Pro Ser Pro Leu  Arg Asn Ile 
    2660                 2665                 2670             


Pro Pro  Phe Glu Gly Cys Ile  Trp Asn Leu Val Ile  Asn Ser Val 
    2675                 2680                 2685             


Pro Met  Asp Phe Ala Arg Pro  Val Ser Phe Lys Asn  Ala Asp Ile 
    2690                 2695                 2700             


Gly Arg  Cys Ala His Gln Lys  Leu Arg Glu Asp Glu  Asp Gly Ala 
    2705                 2710                 2715             


Ala Pro  Ala Glu Ile Val Ile  Gln Pro Glu Pro Val  Pro Thr Pro 
    2720                 2725                 2730             


Ala Phe  Pro Thr Pro Thr Pro  Val Leu Thr His Gly  Pro Cys Ala 
    2735                 2740                 2745             


Ala Glu  Ser Glu Pro Ala Leu  Leu Ile Gly Ser Lys  Gln Phe Gly 
    2750                 2755                 2760             


Leu Ser  Arg Asn Ser His Ile  Ala Ile Ala Phe Asp  Asp Thr Lys 
    2765                 2770                 2775             


Val Lys  Asn Arg Leu Thr Ile  Glu Leu Glu Val Arg  Thr Glu Ala 
    2780                 2785                 2790             


Glu Ser  Gly Leu Leu Phe Tyr  Met Ala Arg Ile Asn  His Ala Asp 
    2795                 2800                 2805             


Phe Ala  Thr Val Gln Leu Arg  Asn Gly Leu Pro Tyr  Phe Ser Tyr 
    2810                 2815                 2820             


Asp Leu  Gly Ser Gly Asp Thr  His Thr Met Ile Pro  Thr Lys Ile 
    2825                 2830                 2835             


Asn Asp  Gly Gln Trp His Lys  Ile Lys Ile Met Arg  Ser Lys Gln 
    2840                 2845                 2850             


Glu Gly  Ile Leu Tyr Val Asp  Gly Ala Ser Asn Arg  Thr Ile Ser 
    2855                 2860                 2865             


Pro Lys  Lys Ala Asp Ile Leu  Asp Val Val Gly Met  Leu Tyr Val 
    2870                 2875                 2880             


Gly Gly  Leu Pro Ile Asn Tyr  Thr Thr Arg Arg Ile  Gly Pro Val 
    2885                 2890                 2895             


Thr Tyr  Ser Ile Asp Gly Cys  Val Arg Asn Leu His  Met Ala Glu 
    2900                 2905                 2910             


Ala Pro  Ala Asp Leu Glu Gln  Pro Thr Ser Ser Phe  His Val Gly 
    2915                 2920                 2925             


Thr Cys  Phe Ala Asn Ala Gln  Arg Gly Thr Tyr Phe  Asp Gly Thr 
    2930                 2935                 2940             


Gly Phe  Ala Lys Ala Val Gly  Gly Phe Lys Val Gly  Leu Asp Leu 
    2945                 2950                 2955             


Leu Val  Glu Phe Glu Phe Arg  Thr Thr Thr Thr Thr  Gly Val Leu 
    2960                 2965                 2970             


Leu Gly  Ile Ser Ser Gln Lys  Met Asp Gly Met Gly  Ile Glu Met 
    2975                 2980                 2985             


Ile Asp  Glu Lys Leu Met Phe  His Val Asp Asn Gly  Ala Gly Arg 
    2990                 2995                 3000             


Phe Thr  Ala Val Tyr Asp Ala  Gly Val Pro Gly His  Leu Cys Asp 
    3005                 3010                 3015             


Gly Gln  Trp His Lys Val Thr  Ala Asn Lys Ile Lys  His Arg Ile 
    3020                 3025                 3030             


Glu Leu  Thr Val Asp Gly Asn  Gln Val Glu Ala Gln  Ser Pro Asn 
    3035                 3040                 3045             


Pro Ala  Ser Thr Ser Ala Asp  Thr Asn Asp Pro Val  Phe Val Gly 
    3050                 3055                 3060             


Gly Phe  Pro Asp Asp Leu Lys  Gln Phe Gly Leu Thr  Thr Ser Ile 
    3065                 3070                 3075             


Pro Phe  Arg Gly Cys Ile Arg  Ser Leu Lys Leu Thr  Lys Gly Thr 
    3080                 3085                 3090             


Gly Lys  Pro Leu Glu Val Asn  Phe Ala Lys Ala Leu  Glu Leu Arg 
    3095                 3100                 3105             


Gly Val  Gln Pro Val Ser Cys  Pro Ala Asn 
    3110                 3115             


<210>  7646
<211>  184
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7646

Xaa Cys Arg Cys Asn Ala Gly Gly Ser Phe Ser Glu Val Cys His Ser 
1               5                   10                  15      


Gln Thr Gly Gln Cys Glu Cys Arg Ala Asn Val Gln Gly Gln Arg Cys 
            20                  25                  30          


Asp Lys Cys Lys Pro Asn Met Trp Arg Asp Pro Glu Lys Arg Phe Cys 
        35                  40                  45              


Val Leu Cys Asp Cys Asp Pro Val Gly Ser Val Ser Pro Gln Cys Asp 
    50                  55                  60                  


Ile Thr Gly Arg Cys Val Cys Lys Ser Gly Phe Val Gly Lys Gln Cys 
65                  70                  75                  80  


Asn Leu Gly Arg Gln Val His Gln Gln Glu Glu Gln Pro Arg Arg Ala 
                85                  90                  95      


Gln Arg Val Leu Gly Ser Pro Gln Arg Trp Ala Ile Gly Ser Ser Ser 
            100                 105                 110         


Gly Cys Pro Arg Gly Ala Tyr Arg Ala Pro Ala Pro Ala Gly Thr Phe 
        115                 120                 125             


Gly Leu Gln Ser Ala Arg Gly Cys Val Pro Cys Asn Cys Asn Ser Phe 
    130                 135                 140                 


Gly Ser Lys Ser Phe Asp Cys Glu Glu Ser Gly Gln Cys Trp Cys Gln 
145                 150                 155                 160 


Pro Gly Val Thr Gly Lys Lys Cys Asp Arg Cys Ala His Gly Tyr Phe 
                165                 170                 175     


Asn Phe Gln Glu Gly Gly Cys Thr 
            180                 


<210>  7647
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  7647

Leu Val Arg Ser Ala Ser Phe Ser Arg Gly Gly Gln Leu Ser Phe Thr 
1               5                   10                  15      


Asp Leu Gly Leu Pro Pro Thr Asp His Leu Gln Ala Ser Phe Gly Phe 
            20                  25                  30          


Gln Thr Phe Gln Pro Ser Gly Ile Leu Leu Asp His Gln Thr Trp Thr 
        35                  40                  45              


Arg Asn Leu Gln Val Thr Leu Glu Asp Gly Tyr Ile Glu Leu Ser Thr 
    50                  55                  60                  


Ser Asp Ser Gly Gly Pro Ile Phe Lys Ser Pro Gln Thr Tyr Met Asp 
65                  70                  75                  80  


Gly Leu Leu His Tyr Val Ser Val Ile Ser Asp Asn Ser Gly 
                85                  90                  


<210>  7648
<211>  3333
<212>  PRT
<213>  Homo Sapiens

<400>  7648

Met Ala Ala Ala Ala Arg Pro Arg Gly Arg Ala Leu Gly Pro Val Leu 
1               5                   10                  15      


Pro Pro Thr Pro Leu Leu Leu Leu Val Leu Arg Val Leu Pro Ala Cys 
            20                  25                  30          


Gly Ala Thr Ala Arg Asp Pro Gly Ala Ala Ala Gly Leu Ser Leu His 
        35                  40                  45              


Pro Thr Tyr Phe Asn Leu Ala Glu Ala Ala Arg Ile Trp Ala Thr Ala 
    50                  55                  60                  


Thr Cys Gly Glu Arg Gly Pro Gly Glu Gly Arg Pro Gln Pro Glu Leu 
65                  70                  75                  80  


Tyr Cys Lys Leu Val Gly Gly Pro Thr Ala Pro Gly Ser Gly His Thr 
                85                  90                  95      


Ile Gln Gly Gln Phe Cys Asp Tyr Cys Asn Ser Glu Asp Pro Arg Lys 
            100                 105                 110         


Ala His Pro Val Thr Asn Ala Ile Asp Gly Ser Glu Arg Trp Trp Gln 
        115                 120                 125             


Ser Pro Pro Leu Ser Ser Gly Thr Gln Tyr Asn Arg Val Asn Leu Thr 
    130                 135                 140                 


Leu Asp Leu Gly Gln Leu Phe His Val Ala Tyr Ile Leu Ile Lys Phe 
145                 150                 155                 160 


Ala Asn Ser Pro Arg Pro Asp Leu Trp Val Leu Glu Arg Ser Val Asp 
                165                 170                 175     


Phe Gly Ser Thr Tyr Ser Pro Trp Gln Tyr Phe Ala His Ser Lys Val 
            180                 185                 190         


Asp Cys Leu Lys Glu Phe Gly Arg Glu Ala Asn Met Ala Val Thr Arg 
        195                 200                 205             


Asp Asp Asp Val Leu Cys Val Thr Glu Tyr Ser Arg Ile Val Pro Leu 
    210                 215                 220                 


Glu Asn Gly Glu Val Val Val Ser Leu Ile Asn Gly Arg Pro Gly Ala 
225                 230                 235                 240 


Lys Asn Phe Thr Phe Ser His Thr Leu Arg Glu Phe Thr Lys Ala Thr 
                245                 250                 255     


Asn Ile Arg Leu Arg Phe Leu Arg Thr Asn Thr Leu Leu Gly His Leu 
            260                 265                 270         


Ile Ser Lys Ala Gln Arg Asp Pro Thr Val Thr Arg Arg Tyr Tyr Tyr 
        275                 280                 285             


Ser Ile Lys Asp Ile Ser Ile Gly Gly Gln Cys Val Cys Asn Gly His 
    290                 295                 300                 


Ala Glu Val Cys Asn Ile Asn Asn Pro Glu Lys Leu Phe Arg Cys Glu 
305                 310                 315                 320 


Cys Gln His His Thr Cys Gly Glu Thr Cys Asp Arg Cys Cys Thr Gly 
                325                 330                 335     


Tyr Asn Gln Arg Arg Trp Arg Pro Ala Ala Trp Glu Gln Ser His Glu 
            340                 345                 350         


Cys Glu Ala Cys Asn Cys His Gly His Ala Ser Asn Cys Tyr Tyr Asp 
        355                 360                 365             


Pro Asp Val Glu Arg Gln Gln Ala Ser Leu Asn Thr Gln Gly Ile Tyr 
    370                 375                 380                 


Ala Gly Gly Gly Val Cys Ile Asn Cys Gln His Asn Thr Ala Gly Val 
385                 390                 395                 400 


Asn Cys Glu Gln Cys Ala Lys Gly Tyr Tyr Arg Pro Tyr Gly Val Pro 
                405                 410                 415     


Val Asp Ala Pro Asp Gly Cys Ile Pro Cys Ser Cys Asp Pro Glu His 
            420                 425                 430         


Ala Asp Gly Cys Glu Gln Gly Ser Gly Arg Cys His Cys Lys Pro Asn 
        435                 440                 445             


Phe His Gly Asp Asn Cys Glu Lys Cys Ala Ile Gly Tyr Tyr Asn Phe 
    450                 455                 460                 


Pro Phe Cys Leu Arg Ile Pro Ile Phe Pro Val Ser Thr Pro Ser Ser 
465                 470                 475                 480 


Glu Asp Pro Val Ala Gly Asp Ile Lys Gly Cys Asp Cys Asn Leu Glu 
                485                 490                 495     


Gly Val Leu Pro Glu Ile Cys Asp Ala His Gly Arg Cys Leu Cys Arg 
            500                 505                 510         


Pro Gly Val Glu Gly Pro Arg Cys Asp Thr Cys Arg Ser Gly Phe Tyr 
        515                 520                 525             


Ser Phe Pro Ile Cys Gln Ala Cys Trp Cys Ser Ala Leu Gly Ser Tyr 
    530                 535                 540                 


Gln Met Pro Cys Ser Ser Val Thr Gly Gln Cys Glu Cys Arg Pro Gly 
545                 550                 555                 560 


Val Thr Gly Gln Arg Cys Asp Arg Cys Leu Ser Gly Ala Tyr Asp Phe 
                565                 570                 575     


Pro His Cys Gln Gly Ser Ser Ser Ala Cys Asp Pro Ala Gly Thr Ile 
            580                 585                 590         


Asn Ser Asn Leu Gly Tyr Cys Gln Cys Lys Leu His Val Glu Gly Pro 
        595                 600                 605             


Thr Cys Ser Arg Cys Lys Leu Leu Tyr Trp Asn Leu Asp Lys Glu Asn 
    610                 615                 620                 


Pro Ser Gly Cys Ser Glu Cys Lys Cys His Lys Ala Gly Thr Val Ser 
625                 630                 635                 640 


Gly Thr Gly Glu Cys Arg Gln Gly Asp Gly Asp Cys His Cys Lys Ser 
                645                 650                 655     


His Val Gly Gly Asp Ser Cys Asp Thr Cys Glu Asp Gly Tyr Phe Ala 
            660                 665                 670         


Leu Glu Lys Ser Asn Tyr Phe Gly Cys Gln Gly Cys Gln Cys Asp Ile 
        675                 680                 685             


Gly Gly Ala Leu Ser Ser Met Cys Ser Gly Pro Ser Gly Val Cys Gln 
    690                 695                 700                 


Cys Arg Glu His Val Val Gly Lys Val Cys Gln Arg Pro Glu Asn Asn 
705                 710                 715                 720 


Tyr Tyr Phe Pro Asp Leu His His Met Lys Tyr Glu Ile Glu Asp Gly 
                725                 730                 735     


Ser Thr Pro Asn Gly Arg Asp Leu Arg Phe Gly Phe Asp Pro Leu Ala 
            740                 745                 750         


Phe Pro Glu Phe Ser Trp Arg Gly Tyr Ala Gln Met Thr Ser Val Gln 
        755                 760                 765             


Asn Asp Val Arg Ile Thr Leu Asn Val Gly Lys Ser Ser Gly Ser Leu 
    770                 775                 780                 


Phe Arg Val Ile Leu Arg Tyr Val Asn Pro Gly Thr Glu Ala Val Ser 
785                 790                 795                 800 


Gly His Ile Thr Ile Tyr Pro Ser Trp Gly Ala Ala Gln Ser Lys Glu 
                805                 810                 815     


Ile Ile Phe Leu Pro Ser Lys Glu Pro Ala Phe Val Thr Val Pro Gly 
            820                 825                 830         


Asn Gly Phe Ala Asp Pro Phe Ser Ile Thr Pro Gly Ile Trp Val Ala 
        835                 840                 845             


Cys Ile Lys Ala Glu Gly Val Leu Leu Asp Tyr Leu Val Leu Leu Pro 
    850                 855                 860                 


Arg Asp Tyr Tyr Glu Ala Ser Val Leu Gln Leu Pro Val Thr Glu Pro 
865                 870                 875                 880 


Cys Ala Tyr Ala Gly Pro Pro Gln Glu Asn Cys Leu Leu Tyr Gln His 
                885                 890                 895     


Leu Pro Val Thr Arg Phe Pro Cys Thr Leu Ala Cys Glu Ala Arg His 
            900                 905                 910         


Phe Leu Leu Asp Gly Glu Pro Arg Pro Val Ala Val Arg Gln Pro Thr 
        915                 920                 925             


Pro Ala His Pro Val Met Val Asp Leu Ser Gly Arg Glu Val Glu Leu 
    930                 935                 940                 


His Leu Arg Leu Arg Ile Pro Gln Val Gly His Tyr Val Val Val Val 
945                 950                 955                 960 


Glu Tyr Ser Thr Glu Ala Ala Gln Leu Phe Val Val Asp Val Asn Val 
                965                 970                 975     


Lys Ser Ser Gly Ser Val Leu Ala Gly Gln Val Asn Ile Tyr Ser Cys 
            980                 985                 990         


Asn Tyr Ser Val Leu Cys Arg Ser  Ala Val Ile Asp His  Met Ser Arg 
        995                 1000                 1005             


Ile Ala  Met Tyr Glu Leu Leu  Ala Asp Ala Asp Ile  Gln Leu Lys 
    1010                 1015                 1020             


Gly His  Met Ala Arg Phe Leu  Leu His Gln Val Cys  Ile Ile Pro 
    1025                 1030                 1035             


Ile Glu  Glu Phe Ser Ala Glu  Tyr Val Arg Pro Gln  Val His Cys 
    1040                 1045                 1050             


Ile Ala  Ser Tyr Gly Arg Phe  Val Asn Gln Ser Ala  Thr Cys Val 
    1055                 1060                 1065             


Ser Leu  Ala His Glu Thr Pro  Pro Thr Ala Leu Ile  Leu Asp Val 
    1070                 1075                 1080             


Leu Ser  Gly Arg Pro Phe Pro  His Leu Pro Gln Gln  Ser Ser Pro 
    1085                 1090                 1095             


Ser Val  Asp Val Leu Pro Gly  Val Thr Leu Lys Ala  Pro Gln Asn 
    1100                 1105                 1110             


Gln Val  Thr Leu Arg Gly Arg  Val Pro His Leu Gly  Arg Tyr Val 
    1115                 1120                 1125             


Phe Val  Ile His Phe Tyr Gln  Ala Ala His Pro Thr  Phe Pro Ala 
    1130                 1135                 1140             


Gln Val  Ser Val Asp Gly Gly  Trp Pro Arg Ala Gly  Ser Phe His 
    1145                 1150                 1155             


Ala Ser  Phe Cys Pro His Val  Leu Gly Cys Arg Asp  Gln Val Ile 
    1160                 1165                 1170             


Ala Glu  Gly Gln Ile Glu Phe  Asp Ile Ser Glu Pro  Glu Val Ala 
    1175                 1180                 1185             


Ala Thr  Val Lys Val Pro Glu  Gly Lys Ser Leu Val  Leu Val Arg 
    1190                 1195                 1200             


Val Leu  Val Val Pro Ala Glu  Asn Tyr Asp Tyr Gln  Ile Leu His 
    1205                 1210                 1215             


Lys Lys  Ser Met Asp Lys Ser  Leu Glu Phe Ile Thr  Asn Cys Gly 
    1220                 1225                 1230             


Lys Asn  Ser Phe Tyr Leu Asp  Pro Gln Thr Ala Ser  Arg Phe Cys 
    1235                 1240                 1245             


Lys Asn  Ser Ala Arg Ser Leu  Val Ala Phe Tyr His  Lys Gly Ala 
    1250                 1255                 1260             


Leu Pro  Cys Glu Cys His Pro  Thr Gly Ala Thr Gly  Pro His Cys 
    1265                 1270                 1275             


Ser Pro  Glu Gly Gly Gln Cys  Pro Cys Gln Pro Asn  Val Ile Gly 
    1280                 1285                 1290             


Arg Gln  Cys Thr Arg Cys Ala  Thr Gly His Tyr Gly  Phe Pro Arg 
    1295                 1300                 1305             


Cys Lys  Pro Cys Ser Cys Gly  Arg Arg Leu Cys Glu  Glu Met Thr 
    1310                 1315                 1320             


Gly Gln  Cys Arg Cys Pro Pro  Arg Thr Val Arg Pro  Gln Cys Glu 
    1325                 1330                 1335             


Val Cys  Glu Thr His Ser Phe  Ser Phe His Pro Met  Ala Gly Cys 
    1340                 1345                 1350             


Glu Gly  Cys Asn Cys Ser Arg  Arg Gly Thr Ile Glu  Ala Ala Met 
    1355                 1360                 1365             


Pro Glu  Cys Asp Arg Asp Ser  Gly Gln Cys Arg Cys  Lys Pro Arg 
    1370                 1375                 1380             


Ile Thr  Gly Arg Gln Cys Asp  Arg Cys Ala Ser Gly  Phe Tyr Arg 
    1385                 1390                 1395             


Phe Pro  Glu Cys Val Pro Cys  Asn Cys Asn Arg Asp  Gly Thr Glu 
    1400                 1405                 1410             


Pro Gly  Val Cys Asp Pro Gly  Thr Gly Ala Cys Leu  Cys Lys Glu 
    1415                 1420                 1425             


Asn Val  Glu Gly Thr Glu Cys  Asn Val Cys Arg Glu  Gly Ser Phe 
    1430                 1435                 1440             


His Leu  Asp Pro Ala Asn Leu  Lys Gly Cys Thr Ser  Cys Phe Cys 
    1445                 1450                 1455             


Phe Gly  Val Asn Asn Gln Cys  His Ser Ser His Lys  Arg Arg Thr 
    1460                 1465                 1470             


Lys Phe  Val Asp Met Leu Gly  Trp His Leu Glu Thr  Ala Asp Arg 
    1475                 1480                 1485             


Val Asp  Ile Pro Val Ser Phe  Asn Pro Gly Ser Asn  Ser Met Val 
    1490                 1495                 1500             


Ala Asp  Leu Gln Glu Leu Pro  Ala Thr Ile His Ser  Ala Ser Trp 
    1505                 1510                 1515             


Val Ala  Pro Thr Ser Tyr Leu  Gly Asp Lys Val Ser  Ser Tyr Gly 
    1520                 1525                 1530             


Gly Tyr  Leu Thr Tyr Gln Ala  Lys Ser Phe Gly Leu  Pro Gly Asp 
    1535                 1540                 1545             


Met Val  Leu Leu Glu Lys Lys  Pro Asp Val Gln Leu  Thr Gly Gln 
    1550                 1555                 1560             


His Met  Ser Ile Ile Tyr Glu  Glu Thr Asn Thr Pro  Arg Pro Asp 
    1565                 1570                 1575             


Arg Leu  His His Gly Arg Val  His Val Val Glu Gly  Asn Phe Arg 
    1580                 1585                 1590             


His Ala  Ser Ser Arg Ala Pro  Val Ser Arg Glu Glu  Leu Met Thr 
    1595                 1600                 1605             


Val Leu  Ser Arg Leu Ala Asp  Val Arg Ile Gln Gly  Leu Tyr Phe 
    1610                 1615                 1620             


Thr Glu  Thr Gln Arg Leu Thr  Leu Ser Glu Val Gly  Leu Glu Glu 
    1625                 1630                 1635             


Ala Ser  Asp Thr Gly Ser Gly  Arg Ile Ala Leu Ala  Val Glu Ile 
    1640                 1645                 1650             


Cys Ala  Cys Pro Pro Ala Tyr  Ala Gly Asp Ser Cys  Gln Gly Cys 
    1655                 1660                 1665             


Ser Pro  Gly Tyr Tyr Arg Asp  His Lys Gly Leu Tyr  Thr Gly Arg 
    1670                 1675                 1680             


Cys Val  Pro Cys Asn Cys Asn  Gly His Ser Asn Gln  Cys Gln Asp 
    1685                 1690                 1695             


Gly Ser  Gly Ile Cys Val Asn  Cys Gln His Asn Thr  Ala Gly Glu 
    1700                 1705                 1710             


His Cys  Glu Arg Cys Gln Glu  Gly Tyr Tyr Gly Asn  Ala Val His 
    1715                 1720                 1725             


Gly Ser  Cys Arg Ala Cys Pro  Cys Pro His Thr Asn  Ser Phe Ala 
    1730                 1735                 1740             


Thr Gly  Cys Val Val Asn Gly  Gly Asp Val Arg Cys  Ser Cys Lys 
    1745                 1750                 1755             


Ala Gly  Tyr Thr Gly Thr Gln  Cys Glu Arg Cys Ala  Pro Gly Tyr 
    1760                 1765                 1770             


Phe Gly  Asn Pro Gln Lys Phe  Gly Gly Ser Cys Gln  Pro Cys Ser 
    1775                 1780                 1785             


Cys Asn  Ser Asn Gly Gln Leu  Gly Ser Cys His Pro  Leu Thr Gly 
    1790                 1795                 1800             


Asp Cys  Ile Asn Gln Glu Pro  Lys Asp Ser Ser Pro  Ala Glu Glu 
    1805                 1810                 1815             


Cys Asp  Asp Cys Asp Ser Cys  Val Met Thr Leu Leu  Asn Asp Leu 
    1820                 1825                 1830             


Ala Thr  Met Gly Glu Gln Leu  Arg Leu Val Lys Ser  Gln Leu Gln 
    1835                 1840                 1845             


Gly Leu  Ser Ala Ser Ala Gly  Leu Leu Glu Gln Met  Arg His Met 
    1850                 1855                 1860             


Glu Thr  Gln Ala Lys Asp Leu  Arg Asn Gln Leu Leu  Asn Tyr Arg 
    1865                 1870                 1875             


Ser Ala  Ile Ser Asn His Gly  Ser Lys Ile Glu Gly  Leu Glu Arg 
    1880                 1885                 1890             


Glu Leu  Thr Asp Leu Asn Gln  Glu Phe Glu Thr Leu  Gln Glu Lys 
    1895                 1900                 1905             


Ala Gln  Val Asn Ser Arg Lys  Ala Gln Thr Leu Asn  Asn Asn Val 
    1910                 1915                 1920             


Asn Arg  Ala Thr Gln Ser Ala  Lys Glu Leu Asp Val  Lys Ile Lys 
    1925                 1930                 1935             


Asn Val  Ile Arg Asn Val His  Ile Leu Leu Lys Gln  Ile Ser Gly 
    1940                 1945                 1950             


Thr Asp  Gly Glu Gly Asn Asn  Val Pro Ser Gly Asp  Phe Ser Arg 
    1955                 1960                 1965             


Glu Trp  Ala Glu Ala Gln Arg  Met Met Arg Glu Leu  Arg Asn Arg 
    1970                 1975                 1980             


Asn Phe  Gly Lys His Leu Arg  Glu Ala Glu Ala Asp  Lys Arg Glu 
    1985                 1990                 1995             


Ser Gln  Leu Leu Leu Asn Arg  Ile Arg Thr Trp Gln  Lys Thr His 
    2000                 2005                 2010             


Gln Gly  Glu Asn Asn Gly Leu  Ala Asn Ser Ile Arg  Asp Ser Leu 
    2015                 2020                 2025             


Asn Glu  Tyr Glu Ala Lys Leu  Ser Asp Leu Arg Ala  Arg Leu Gln 
    2030                 2035                 2040             


Glu Ala  Ala Ala Gln Ala Lys  Gln Ala Asn Gly Leu  Asn Gln Glu 
    2045                 2050                 2055             


Asn Glu  Arg Ala Leu Gly Ala  Ile Gln Arg Gln Val  Lys Glu Ile 
    2060                 2065                 2070             


Asn Ser  Leu Gln Ser Asp Phe  Thr Lys Tyr Leu Thr  Thr Ala Asp 
    2075                 2080                 2085             


Ser Ser  Leu Leu Gln Thr Asn  Ile Ala Leu Gln Leu  Met Glu Lys 
    2090                 2095                 2100             


Ser Gln  Lys Glu Tyr Glu Lys  Leu Ala Ala Ser Leu  Asn Glu Ala 
    2105                 2110                 2115             


Arg Gln  Glu Leu Ser Asp Lys  Val Arg Glu Leu Ser  Arg Ser Ala 
    2120                 2125                 2130             


Gly Lys  Thr Ser Leu Val Glu  Glu Ala Glu Lys His  Ala Arg Ser 
    2135                 2140                 2145             


Leu Gln  Glu Leu Ala Lys Gln  Leu Glu Glu Ile Lys  Arg Asn Ala 
    2150                 2155                 2160             


Ser Gly  Asp Glu Leu Val Arg  Cys Ala Val Asp Ala  Ala Thr Ala 
    2165                 2170                 2175             


Tyr Glu  Asn Ile Leu Asn Ala  Ile Lys Ala Ala Glu  Asp Ala Ala 
    2180                 2185                 2190             


Asn Arg  Ala Ala Ser Ala Ser  Glu Ser Ala Leu Gln  Thr Val Ile 
    2195                 2200                 2205             


Lys Glu  Asp Leu Pro Arg Lys  Ala Lys Thr Leu Ser  Ser Asn Ser 
    2210                 2215                 2220             


Asp Lys  Leu Leu Asn Glu Ala  Lys Met Thr Gln Lys  Lys Leu Lys 
    2225                 2230                 2235             


Gln Glu  Val Ser Pro Ala Leu  Asn Asn Leu Gln Gln  Thr Leu Asn 
    2240                 2245                 2250             


Ile Val  Thr Val Gln Lys Glu  Val Ile Asp Thr Asn  Leu Thr Thr 
    2255                 2260                 2265             


Leu Arg  Asp Gly Leu His Gly  Ile Gln Arg Gly Asp  Ile Asp Ala 
    2270                 2275                 2280             


Met Ile  Ser Ser Ala Lys Ser  Met Val Arg Lys Ala  Asn Asp Ile 
    2285                 2290                 2295             


Thr Asp  Glu Val Leu Asp Gly  Leu Asn Pro Ile Gln  Thr Asp Val 
    2300                 2305                 2310             


Glu Arg  Ile Lys Asp Thr Tyr  Gly Arg Thr Gln Asn  Glu Asp Phe 
    2315                 2320                 2325             


Lys Lys  Ala Leu Thr Asp Ala  Asp Asn Ser Val Asn  Lys Leu Thr 
    2330                 2335                 2340             


Asn Lys  Leu Pro Asp Leu Trp  Arg Lys Ile Glu Ser  Ile Asn Gln 
    2345                 2350                 2355             


Gln Leu  Leu Pro Leu Gly Asn  Ile Ser Asp Asn Met  Asp Arg Ile 
    2360                 2365                 2370             


Arg Glu  Leu Ile Gln Gln Ala  Arg Asp Ala Ala Ser  Lys Val Ala 
    2375                 2380                 2385             


Val Pro  Met Arg Phe Asn Gly  Lys Ser Gly Val Glu  Val Arg Leu 
    2390                 2395                 2400             


Pro Asn  Asp Leu Glu Asp Leu  Lys Gly Tyr Thr Ser  Leu Ser Leu 
    2405                 2410                 2415             


Phe Leu  Gln Arg Pro Asn Ser  Arg Glu Asn Gly Gly  Thr Glu Asn 
    2420                 2425                 2430             


Met Phe  Val Met Tyr Leu Gly  Asn Lys Asp Ala Ser  Arg Asp Tyr 
    2435                 2440                 2445             


Ile Gly  Met Ala Val Val Asp  Gly Gln Leu Thr Cys  Val Tyr Asn 
    2450                 2455                 2460             


Leu Gly  Asp Arg Glu Ala Glu  Leu Gln Val Asp Gln  Ile Leu Thr 
    2465                 2470                 2475             


Lys Ser  Glu Thr Lys Glu Ala  Val Met Asp Arg Val  Lys Phe Gln 
    2480                 2485                 2490             


Arg Ile  Tyr Gln Phe Ala Arg  Leu Asn Tyr Thr Lys  Gly Ala Thr 
    2495                 2500                 2505             


Ser Ser  Lys Pro Glu Thr Pro  Gly Val Tyr Asp Met  Asp Gly Arg 
    2510                 2515                 2520             


Asn Ser  Asn Thr Leu Leu Asn  Leu Asp Pro Glu Asn  Val Val Phe 
    2525                 2530                 2535             


Tyr Val  Gly Gly Tyr Pro Pro  Asp Phe Lys Leu Pro  Ser Arg Leu 
    2540                 2545                 2550             


Ser Phe  Pro Pro Tyr Lys Gly  Cys Ile Glu Leu Asp  Asp Leu Asn 
    2555                 2560                 2565             


Glu Asn  Val Leu Ser Leu Tyr  Asn Phe Lys Lys Thr  Phe Asn Leu 
    2570                 2575                 2580             


Asn Thr  Thr Glu Val Glu Pro  Cys Arg Arg Arg Lys  Glu Glu Ser 
    2585                 2590                 2595             


Asp Lys  Asn Tyr Phe Glu Gly  Thr Gly Tyr Ala Arg  Val Pro Thr 
    2600                 2605                 2610             


Gln Pro  His Ala Pro Ile Pro  Thr Phe Gly Gln Thr  Ile Gln Thr 
    2615                 2620                 2625             


Thr Val  Asp Arg Gly Leu Leu  Phe Phe Ala Glu Asn  Gly Asp Arg 
    2630                 2635                 2640             


Phe Ile  Ser Leu Asn Ile Glu  Asp Gly Lys Leu Met  Val Arg Tyr 
    2645                 2650                 2655             


Lys Leu  Asn Ser Glu Leu Pro  Lys Glu Arg Gly Val  Gly Asp Ala 
    2660                 2665                 2670             


Ile Asn  Asn Gly Arg Asp His  Ser Ile Gln Ile Lys  Ile Gly Lys 
    2675                 2680                 2685             


Leu Gln  Lys Arg Met Trp Ile  Asn Val Asp Val Gln  Asn Thr Ile 
    2690                 2695                 2700             


Ile Asp  Gly Glu Val Phe Asp  Phe Ser Thr Tyr Tyr  Leu Gly Gly 
    2705                 2710                 2715             


Ile Pro  Ile Ala Ile Arg Glu  Arg Phe Asn Ile Ser  Thr Pro Ala 
    2720                 2725                 2730             


Phe Arg  Gly Cys Met Lys Asn  Leu Lys Lys Thr Ser  Gly Val Val 
    2735                 2740                 2745             


Arg Leu  Asn Asp Thr Val Gly  Val Thr Lys Lys Cys  Ser Glu Asp 
    2750                 2755                 2760             


Trp Lys  Leu Val Arg Ser Ala  Ser Phe Ser Arg Gly  Gly Gln Leu 
    2765                 2770                 2775             


Ser Phe  Thr Asp Leu Gly Leu  Pro Pro Thr Asp His  Leu Gln Ala 
    2780                 2785                 2790             


Ser Phe  Gly Phe Gln Thr Phe  Gln Pro Ser Gly Ile  Leu Leu Asp 
    2795                 2800                 2805             


His Gln  Thr Trp Thr Arg Asn  Leu Gln Val Thr Leu  Glu Asp Gly 
    2810                 2815                 2820             


Tyr Ile  Glu Leu Ser Thr Ser  Asp Ser Gly Gly Pro  Ile Phe Lys 
    2825                 2830                 2835             


Ser Pro  Gln Thr Tyr Met Asp  Gly Leu Leu His Tyr  Val Ser Val 
    2840                 2845                 2850             


Ile Ser  Asp Asn Ser Gly Leu  Arg Leu Leu Ile Asp  Asp Gln Leu 
    2855                 2860                 2865             


Leu Arg  Asn Ser Lys Arg Leu  Lys His Ile Ser Ser  Ser Arg Gln 
    2870                 2875                 2880             


Ser Leu  Arg Leu Gly Gly Ser  Asn Phe Glu Gly Cys  Ile Ser Asn 
    2885                 2890                 2895             


Val Phe  Val Gln Arg Leu Ser  Leu Ser Pro Glu Val  Leu Asp Leu 
    2900                 2905                 2910             


Thr Ser  Asn Ser Leu Lys Arg  Asp Val Ser Leu Gly  Gly Cys Ser 
    2915                 2920                 2925             


Leu Asn  Lys Pro Pro Phe Leu  Met Leu Leu Lys Gly  Ser Thr Arg 
    2930                 2935                 2940             


Phe Asn  Lys Thr Lys Thr Phe  Arg Ile Asn Gln Leu  Leu Gln Asp 
    2945                 2950                 2955             


Thr Pro  Val Ala Ser Pro Arg  Ser Val Lys Val Trp  Gln Asp Ala 
    2960                 2965                 2970             


Cys Ser  Pro Leu Pro Lys Thr  Gln Ala Asn His Gly  Ala Leu Gln 
    2975                 2980                 2985             


Phe Gly  Asp Ile Pro Thr Ser  His Leu Leu Phe Lys  Leu Pro Gln 
    2990                 2995                 3000             


Glu Leu  Leu Lys Pro Arg Ser  Gln Phe Ala Val Asp  Met Gln Thr 
    3005                 3010                 3015             


Thr Ser  Ser Arg Gly Leu Val  Phe His Thr Gly Thr  Lys Asn Ser 
    3020                 3025                 3030             


Phe Met  Ala Leu Tyr Leu Ser  Lys Gly Arg Leu Val  Phe Ala Leu 
    3035                 3040                 3045             


Gly Thr  Asp Gly Lys Lys Leu  Arg Ile Lys Ser Lys  Glu Lys Cys 
    3050                 3055                 3060             


Asn Asp  Gly Lys Trp His Thr  Val Val Phe Gly His  Asp Gly Glu 
    3065                 3070                 3075             


Lys Gly  Arg Leu Val Val Asp  Gly Leu Arg Ala Arg  Glu Gly Ser 
    3080                 3085                 3090             


Leu Pro  Gly Asn Ser Thr Ile  Ser Ile Arg Ala Pro  Val Tyr Leu 
    3095                 3100                 3105             


Gly Ser  Pro Pro Ser Gly Lys  Pro Lys Ser Leu Pro  Thr Asn Ser 
    3110                 3115                 3120             


Phe Val  Gly Cys Leu Lys Asn  Phe Gln Leu Asp Ser  Lys Pro Leu 
    3125                 3130                 3135             


Tyr Thr  Pro Ser Ser Ser Phe  Gly Val Ser Ser Cys  Leu Gly Gly 
    3140                 3145                 3150             


Pro Leu  Glu Lys Gly Ile Tyr  Phe Ser Glu Glu Gly  Gly His Val 
    3155                 3160                 3165             


Val Leu  Ala His Ser Val Leu  Leu Gly Pro Glu Phe  Lys Leu Val 
    3170                 3175                 3180             


Phe Ser  Ile Arg Pro Arg Ser  Leu Thr Gly Ile Leu  Ile His Ile 
    3185                 3190                 3195             


Gly Ser  Gln Pro Gly Lys His  Leu Cys Val Tyr Leu  Glu Ala Gly 
    3200                 3205                 3210             


Lys Val  Thr Ala Ser Met Asp  Ser Gly Ala Gly Gly  Thr Ser Thr 
    3215                 3220                 3225             


Ser Val  Thr Pro Lys Gln Ser  Leu Cys Asp Gly Gln  Trp His Ser 
    3230                 3235                 3240             


Val Ala  Val Thr Ile Lys Gln  His Ile Leu His Leu  Glu Leu Asp 
    3245                 3250                 3255             


Thr Asp  Ser Ser Tyr Thr Ala  Gly Gln Ile Pro Phe  Pro Pro Ala 
    3260                 3265                 3270             


Ser Thr  Gln Glu Pro Leu His  Leu Gly Gly Ala Pro  Ala Asn Leu 
    3275                 3280                 3285             


Thr Thr  Leu Arg Ile Pro Val  Trp Lys Ser Phe Phe  Gly Cys Leu 
    3290                 3295                 3300             


Arg Asn  Ile His Val Asn His  Ile Pro Val Pro Val  Thr Glu Ala 
    3305                 3310                 3315             


Leu Glu  Val Gln Gly Pro Val  Ser Leu Asn Gly Cys  Pro Asp Gln 
    3320                 3325                 3330             


<210>  7649
<211>  3277
<212>  PRT
<213>  Homo Sapiens

<400>  7649

Met Ala Ala Ala Ala Arg Pro Arg Gly Arg Ala Leu Gly Pro Val Leu 
1               5                   10                  15      


Pro Pro Thr Pro Leu Leu Leu Leu Val Leu Arg Val Leu Pro Ala Cys 
            20                  25                  30          


Gly Ala Thr Ala Arg Asp Pro Gly Ala Ala Ala Gly Leu Ser Leu His 
        35                  40                  45              


Pro Thr Tyr Phe Asn Leu Ala Glu Ala Ala Arg Ile Trp Ala Thr Ala 
    50                  55                  60                  


Thr Cys Gly Glu Arg Gly Pro Gly Glu Gly Arg Pro Gln Pro Glu Leu 
65                  70                  75                  80  


Tyr Cys Lys Leu Val Gly Gly Pro Thr Ala Pro Gly Ser Gly His Thr 
                85                  90                  95      


Ile Gln Gly Gln Phe Cys Asp Tyr Cys Asn Ser Glu Asp Pro Arg Lys 
            100                 105                 110         


Ala His Pro Val Thr Asn Ala Ile Asp Gly Ser Glu Arg Trp Trp Gln 
        115                 120                 125             


Ser Pro Pro Leu Ser Ser Gly Thr Gln Tyr Asn Arg Val Asn Leu Thr 
    130                 135                 140                 


Leu Asp Leu Gly Gln Leu Phe His Val Ala Tyr Ile Leu Ile Lys Phe 
145                 150                 155                 160 


Ala Asn Ser Pro Arg Pro Asp Leu Trp Val Leu Glu Arg Ser Val Asp 
                165                 170                 175     


Phe Gly Ser Thr Tyr Ser Pro Trp Gln Tyr Phe Ala His Ser Lys Val 
            180                 185                 190         


Asp Cys Leu Lys Glu Phe Gly Arg Glu Ala Asn Met Ala Val Thr Arg 
        195                 200                 205             


Asp Asp Asp Val Leu Cys Val Thr Glu Tyr Ser Arg Ile Val Pro Leu 
    210                 215                 220                 


Glu Asn Gly Glu Val Val Val Ser Leu Ile Asn Gly Arg Pro Gly Ala 
225                 230                 235                 240 


Lys Asn Phe Thr Phe Ser His Thr Leu Arg Glu Phe Thr Lys Ala Thr 
                245                 250                 255     


Asn Ile Arg Leu Arg Phe Leu Arg Thr Asn Thr Leu Leu Gly His Leu 
            260                 265                 270         


Ile Ser Lys Ala Gln Arg Asp Pro Thr Val Thr Arg Arg Tyr Tyr Tyr 
        275                 280                 285             


Ser Ile Lys Asp Ile Ser Ile Gly Gly Gln Cys Val Cys Asn Gly His 
    290                 295                 300                 


Ala Glu Val Cys Asn Ile Asn Asn Pro Glu Lys Leu Phe Arg Cys Glu 
305                 310                 315                 320 


Cys Gln His His Thr Cys Gly Glu Thr Cys Asp Arg Cys Cys Thr Gly 
                325                 330                 335     


Tyr Asn Gln Arg Arg Trp Arg Pro Ala Ala Trp Glu Gln Ser His Glu 
            340                 345                 350         


Cys Glu Ala Cys Asn Cys His Gly His Ala Ser Asn Cys Tyr Tyr Asp 
        355                 360                 365             


Pro Asp Val Glu Arg Gln Gln Ala Ser Leu Asn Thr Gln Gly Ile Tyr 
    370                 375                 380                 


Ala Gly Gly Gly Val Cys Ile Asn Cys Gln His Asn Thr Ala Gly Val 
385                 390                 395                 400 


Asn Cys Glu Gln Cys Ala Lys Gly Tyr Tyr Arg Pro Tyr Gly Val Pro 
                405                 410                 415     


Val Asp Ala Pro Asp Gly Cys Ile Pro Cys Ser Cys Asp Pro Glu His 
            420                 425                 430         


Ala Asp Gly Cys Glu Gln Gly Ser Gly Arg Cys His Cys Lys Pro Asn 
        435                 440                 445             


Phe His Gly Asp Asn Cys Glu Lys Cys Ala Ile Gly Tyr Tyr Asn Phe 
    450                 455                 460                 


Pro Phe Cys Leu Arg Ile Pro Ile Phe Pro Val Ser Thr Pro Ser Ser 
465                 470                 475                 480 


Glu Asp Pro Val Ala Gly Asp Ile Lys Gly Cys Asp Cys Asn Leu Glu 
                485                 490                 495     


Gly Val Leu Pro Glu Ile Cys Asp Ala His Gly Arg Cys Leu Cys Arg 
            500                 505                 510         


Pro Gly Val Glu Gly Pro Arg Cys Asp Thr Cys Arg Ser Gly Phe Tyr 
        515                 520                 525             


Ser Phe Pro Ile Cys Gln Ala Cys Trp Cys Ser Ala Leu Gly Ser Tyr 
    530                 535                 540                 


Gln Met Pro Cys Ser Ser Val Thr Gly Gln Cys Glu Cys Arg Pro Gly 
545                 550                 555                 560 


Val Thr Gly Gln Arg Cys Asp Arg Cys Leu Ser Gly Ala Tyr Asp Phe 
                565                 570                 575     


Pro His Cys Gln Gly Ser Ser Ser Ala Cys Asp Pro Ala Gly Thr Ile 
            580                 585                 590         


Asn Ser Asn Leu Gly Tyr Cys Gln Cys Lys Leu His Val Glu Gly Pro 
        595                 600                 605             


Thr Cys Ser Arg Cys Lys Leu Leu Tyr Trp Asn Leu Asp Lys Glu Asn 
    610                 615                 620                 


Pro Ser Gly Cys Ser Glu Cys Lys Cys His Lys Ala Gly Thr Val Ser 
625                 630                 635                 640 


Gly Thr Gly Glu Cys Arg Gln Gly Asp Gly Asp Cys His Cys Lys Ser 
                645                 650                 655     


His Val Gly Gly Asp Ser Cys Asp Thr Cys Glu Asp Gly Tyr Phe Ala 
            660                 665                 670         


Leu Glu Lys Ser Asn Tyr Phe Gly Cys Gln Gly Cys Gln Cys Asp Ile 
        675                 680                 685             


Gly Gly Ala Leu Ser Ser Met Cys Ser Gly Pro Ser Gly Val Cys Gln 
    690                 695                 700                 


Cys Arg Glu His Val Val Gly Lys Val Cys Gln Arg Pro Glu Asn Asn 
705                 710                 715                 720 


Tyr Tyr Phe Pro Asp Leu His His Met Lys Tyr Glu Ile Glu Asp Gly 
                725                 730                 735     


Ser Thr Pro Asn Gly Arg Asp Leu Arg Phe Gly Phe Asp Pro Leu Ala 
            740                 745                 750         


Phe Pro Glu Phe Ser Trp Arg Gly Tyr Ala Gln Met Thr Ser Val Gln 
        755                 760                 765             


Asn Asp Val Arg Ile Thr Leu Asn Val Gly Lys Ser Ser Gly Ser Leu 
    770                 775                 780                 


Phe Arg Val Ile Leu Arg Tyr Val Asn Pro Gly Thr Glu Ala Val Ser 
785                 790                 795                 800 


Gly His Ile Thr Ile Tyr Pro Ser Trp Gly Ala Ala Gln Ser Lys Glu 
                805                 810                 815     


Ile Ile Phe Leu Pro Ser Lys Glu Pro Ala Phe Val Thr Val Pro Gly 
            820                 825                 830         


Asn Gly Phe Ala Asp Pro Phe Ser Ile Thr Pro Gly Ile Trp Val Ala 
        835                 840                 845             


Cys Ile Lys Ala Glu Gly Val Leu Leu Asp Tyr Leu Val Leu Leu Pro 
    850                 855                 860                 


Arg Asp Tyr Tyr Glu Ala Ser Val Leu Gln Leu Pro Val Thr Glu Pro 
865                 870                 875                 880 


Cys Ala Tyr Ala Gly Pro Pro Gln Glu Asn Cys Leu Leu Tyr Gln His 
                885                 890                 895     


Leu Pro Val Thr Arg Phe Pro Cys Thr Leu Ala Cys Glu Ala Arg His 
            900                 905                 910         


Phe Leu Leu Asp Gly Glu Pro Arg Pro Val Ala Val Arg Gln Pro Thr 
        915                 920                 925             


Pro Ala His Pro Val Met Val Asp Leu Ser Gly Arg Glu Val Glu Leu 
    930                 935                 940                 


His Leu Arg Leu Arg Ile Pro Gln Val Gly His Tyr Val Val Val Val 
945                 950                 955                 960 


Glu Tyr Ser Thr Glu Ala Ala Gln Leu Phe Val Val Asp Val Asn Val 
                965                 970                 975     


Lys Ser Ser Gly Ser Val Leu Ala Gly Gln Val Asn Ile Tyr Ser Cys 
            980                 985                 990         


Asn Tyr Ser Val Leu Cys Arg Ser  Ala Val Ile Asp His  Met Ser Arg 
        995                 1000                 1005             


Ile Ala  Met Tyr Glu Leu Leu  Ala Asp Ala Asp Ile  Gln Leu Lys 
    1010                 1015                 1020             


Gly His  Met Ala Arg Phe Leu  Leu His Gln Val Cys  Ile Ile Pro 
    1025                 1030                 1035             


Ile Glu  Glu Phe Ser Ala Glu  Tyr Val Arg Pro Gln  Val His Cys 
    1040                 1045                 1050             


Ile Ala  Ser Tyr Gly Arg Phe  Val Asn Gln Ser Ala  Thr Cys Val 
    1055                 1060                 1065             


Ser Leu  Ala His Glu Thr Pro  Pro Thr Ala Leu Ile  Leu Asp Val 
    1070                 1075                 1080             


Leu Ser  Gly Arg Pro Phe Pro  His Leu Pro Gln Gln  Ser Ser Pro 
    1085                 1090                 1095             


Ser Val  Asp Val Leu Pro Gly  Val Thr Leu Lys Ala  Pro Gln Asn 
    1100                 1105                 1110             


Gln Val  Thr Leu Arg Gly Arg  Val Pro His Leu Gly  Arg Tyr Val 
    1115                 1120                 1125             


Phe Val  Ile His Phe Tyr Gln  Ala Ala His Pro Thr  Phe Pro Ala 
    1130                 1135                 1140             


Gln Val  Ser Val Asp Gly Gly  Trp Pro Arg Ala Gly  Ser Phe His 
    1145                 1150                 1155             


Ala Ser  Phe Cys Pro His Val  Leu Gly Cys Arg Asp  Gln Val Ile 
    1160                 1165                 1170             


Ala Glu  Gly Gln Ile Glu Phe  Asp Ile Ser Glu Pro  Glu Val Ala 
    1175                 1180                 1185             


Ala Thr  Val Lys Val Pro Glu  Gly Lys Ser Leu Val  Leu Val Arg 
    1190                 1195                 1200             


Val Leu  Val Val Pro Ala Glu  Asn Tyr Asp Tyr Gln  Ile Leu His 
    1205                 1210                 1215             


Lys Lys  Ser Met Asp Lys Ser  Leu Glu Phe Ile Thr  Asn Cys Gly 
    1220                 1225                 1230             


Lys Asn  Ser Phe Tyr Leu Asp  Pro Gln Thr Ala Ser  Arg Phe Cys 
    1235                 1240                 1245             


Lys Asn  Ser Ala Arg Ser Leu  Val Ala Phe Tyr His  Lys Gly Ala 
    1250                 1255                 1260             


Leu Pro  Cys Glu Cys His Pro  Thr Gly Ala Thr Gly  Pro His Cys 
    1265                 1270                 1275             


Ser Pro  Glu Gly Gly Gln Cys  Pro Cys Gln Pro Asn  Val Ile Gly 
    1280                 1285                 1290             


Arg Gln  Cys Thr Arg Cys Ala  Thr Gly His Tyr Gly  Phe Pro Arg 
    1295                 1300                 1305             


Cys Lys  Pro Cys Ser Cys Gly  Arg Arg Leu Cys Glu  Glu Met Thr 
    1310                 1315                 1320             


Gly Gln  Cys Arg Cys Pro Pro  Arg Thr Val Arg Pro  Gln Cys Glu 
    1325                 1330                 1335             


Val Cys  Glu Thr His Ser Phe  Ser Phe His Pro Met  Ala Gly Cys 
    1340                 1345                 1350             


Glu Gly  Cys Asn Cys Ser Arg  Arg Gly Thr Ile Glu  Ala Ala Met 
    1355                 1360                 1365             


Pro Glu  Cys Asp Arg Asp Ser  Gly Gln Cys Arg Cys  Lys Pro Arg 
    1370                 1375                 1380             


Ile Thr  Gly Arg Gln Cys Asp  Arg Cys Ala Ser Gly  Phe Tyr Arg 
    1385                 1390                 1395             


Phe Pro  Glu Cys Val Pro Cys  Asn Cys Asn Arg Asp  Gly Thr Glu 
    1400                 1405                 1410             


Pro Gly  Val Cys Asp Pro Gly  Thr Gly Ala Cys Leu  Cys Lys Glu 
    1415                 1420                 1425             


Asn Val  Glu Gly Thr Glu Cys  Asn Val Cys Arg Glu  Gly Ser Phe 
    1430                 1435                 1440             


His Leu  Asp Pro Ala Asn Leu  Lys Gly Cys Thr Ser  Cys Phe Cys 
    1445                 1450                 1455             


Phe Gly  Val Asn Asn Gln Cys  His Ser Ser His Lys  Arg Arg Thr 
    1460                 1465                 1470             


Lys Phe  Val Asp Met Leu Gly  Trp His Leu Glu Thr  Ala Asp Arg 
    1475                 1480                 1485             


Val Asp  Ile Pro Val Ser Phe  Asn Pro Gly Ser Asn  Ser Met Val 
    1490                 1495                 1500             


Ala Asp  Leu Gln Glu Leu Pro  Ala Thr Ile His Ser  Ala Ser Trp 
    1505                 1510                 1515             


Val Ala  Pro Thr Ser Tyr Leu  Gly Asp Lys Val Ser  Ser Tyr Gly 
    1520                 1525                 1530             


Gly Tyr  Leu Thr Tyr Gln Ala  Lys Ser Phe Gly Leu  Pro Gly Asp 
    1535                 1540                 1545             


Met Val  Leu Leu Glu Lys Lys  Pro Asp Val Gln Leu  Thr Gly Gln 
    1550                 1555                 1560             


His Met  Ser Ile Ile Tyr Glu  Glu Thr Asn Thr Pro  Arg Pro Asp 
    1565                 1570                 1575             


Arg Leu  His His Gly Arg Val  His Val Val Glu Gly  Asn Phe Arg 
    1580                 1585                 1590             


His Ala  Ser Ser Arg Ala Pro  Val Ser Arg Glu Glu  Leu Met Thr 
    1595                 1600                 1605             


Val Leu  Ser Arg Leu Ala Asp  Val Arg Ile Gln Gly  Leu Tyr Phe 
    1610                 1615                 1620             


Thr Glu  Thr Gln Arg Leu Thr  Leu Ser Glu Val Gly  Leu Glu Glu 
    1625                 1630                 1635             


Ala Ser  Asp Thr Gly Ser Gly  Arg Ile Ala Leu Ala  Val Glu Ile 
    1640                 1645                 1650             


Cys Ala  Cys Pro Pro Ala Tyr  Ala Gly Asp Ser Cys  Gln Gly Cys 
    1655                 1660                 1665             


Ser Pro  Gly Tyr Tyr Arg Asp  His Lys Gly Leu Tyr  Thr Gly Arg 
    1670                 1675                 1680             


Cys Val  Pro Cys Asn Cys Asn  Gly His Ser Asn Gln  Cys Gln Asp 
    1685                 1690                 1695             


Gly Ser  Gly Ile Cys Val Asn  Cys Gln His Asn Thr  Ala Gly Glu 
    1700                 1705                 1710             


His Cys  Glu Arg Cys Gln Glu  Gly Tyr Tyr Gly Asn  Ala Val His 
    1715                 1720                 1725             


Gly Ser  Cys Arg Ala Cys Pro  Cys Pro His Thr Asn  Ser Phe Ala 
    1730                 1735                 1740             


Thr Gly  Cys Val Val Asn Gly  Gly Asp Val Arg Cys  Ser Cys Lys 
    1745                 1750                 1755             


Ala Gly  Tyr Thr Gly Thr Gln  Cys Glu Arg Cys Ala  Pro Gly Tyr 
    1760                 1765                 1770             


Phe Gly  Asn Pro Gln Lys Phe  Gly Gly Ser Cys Gln  Pro Cys Ser 
    1775                 1780                 1785             


Cys Asn  Ser Asn Gly Gln Leu  Gly Ser Cys His Pro  Leu Thr Gly 
    1790                 1795                 1800             


Asp Cys  Ile Asn Gln Glu Pro  Lys Asp Ser Ser Pro  Ala Glu Glu 
    1805                 1810                 1815             


Cys Asp  Asp Cys Asp Ser Cys  Val Met Thr Leu Leu  Asn Asp Leu 
    1820                 1825                 1830             


Ala Thr  Met Gly Glu Gln Leu  Arg Leu Val Lys Ser  Gln Leu Gln 
    1835                 1840                 1845             


Gly Leu  Ser Ala Ser Ala Gly  Leu Leu Glu Gln Met  Arg His Met 
    1850                 1855                 1860             


Glu Thr  Gln Ala Lys Asp Leu  Arg Asn Gln Leu Leu  Asn Tyr Arg 
    1865                 1870                 1875             


Ser Ala  Ile Ser Asn His Gly  Ser Lys Ile Glu Gly  Leu Glu Arg 
    1880                 1885                 1890             


Glu Leu  Thr Asp Leu Asn Gln  Glu Phe Glu Thr Leu  Gln Glu Lys 
    1895                 1900                 1905             


Ala Gln  Val Asn Ser Arg Lys  Ala Gln Thr Leu Asn  Asn Asn Val 
    1910                 1915                 1920             


Asn Arg  Ala Thr Gln Ser Ala  Lys Glu Leu Asp Val  Lys Ile Lys 
    1925                 1930                 1935             


Asn Val  Ile Arg Asn Val His  Met Leu Asn Arg Ile  Arg Thr Trp 
    1940                 1945                 1950             


Gln Lys  Thr His Gln Gly Glu  Asn Asn Gly Leu Ala  Asn Ser Ile 
    1955                 1960                 1965             


Arg Asp  Ser Leu Asn Glu Tyr  Glu Ala Lys Leu Ser  Asp Leu Arg 
    1970                 1975                 1980             


Ala Arg  Leu Gln Glu Ala Ala  Ala Gln Ala Lys Gln  Ala Asn Gly 
    1985                 1990                 1995             


Leu Asn  Gln Glu Asn Glu Arg  Ala Leu Gly Ala Ile  Gln Arg Gln 
    2000                 2005                 2010             


Val Lys  Glu Ile Asn Ser Leu  Gln Ser Asp Phe Thr  Lys Tyr Leu 
    2015                 2020                 2025             


Thr Thr  Ala Asp Ser Ser Leu  Leu Gln Thr Asn Ile  Ala Leu Gln 
    2030                 2035                 2040             


Leu Met  Glu Lys Ser Gln Lys  Glu Tyr Glu Lys Leu  Ala Ala Ser 
    2045                 2050                 2055             


Leu Asn  Glu Ala Arg Gln Glu  Leu Ser Asp Lys Val  Arg Glu Leu 
    2060                 2065                 2070             


Ser Arg  Ser Ala Gly Lys Thr  Ser Leu Val Glu Glu  Ala Glu Lys 
    2075                 2080                 2085             


His Ala  Arg Ser Leu Gln Glu  Leu Ala Lys Gln Leu  Glu Glu Ile 
    2090                 2095                 2100             


Lys Arg  Asn Ala Ser Gly Asp  Glu Leu Val Arg Cys  Ala Val Asp 
    2105                 2110                 2115             


Ala Ala  Thr Ala Tyr Glu Asn  Ile Leu Asn Ala Ile  Lys Ala Ala 
    2120                 2125                 2130             


Glu Asp  Ala Ala Asn Arg Ala  Ala Ser Ala Ser Glu  Ser Ala Leu 
    2135                 2140                 2145             


Gln Thr  Val Ile Lys Glu Asp  Leu Pro Arg Lys Ala  Lys Thr Leu 
    2150                 2155                 2160             


Ser Ser  Asn Ser Asp Lys Leu  Leu Asn Glu Ala Lys  Met Thr Gln 
    2165                 2170                 2175             


Lys Lys  Leu Lys Gln Glu Val  Ser Pro Ala Leu Asn  Asn Leu Gln 
    2180                 2185                 2190             


Gln Thr  Leu Asn Ile Val Thr  Val Gln Lys Glu Val  Ile Asp Thr 
    2195                 2200                 2205             


Asn Leu  Thr Thr Leu Arg Asp  Gly Leu His Gly Ile  Gln Arg Gly 
    2210                 2215                 2220             


Asp Ile  Asp Ala Met Ile Ser  Ser Ala Lys Ser Met  Val Arg Lys 
    2225                 2230                 2235             


Ala Asn  Asp Ile Thr Asp Glu  Val Leu Asp Gly Leu  Asn Pro Ile 
    2240                 2245                 2250             


Gln Thr  Asp Val Glu Arg Ile  Lys Asp Thr Tyr Gly  Arg Thr Gln 
    2255                 2260                 2265             


Asn Glu  Asp Phe Lys Lys Ala  Leu Thr Asp Ala Asp  Asn Ser Val 
    2270                 2275                 2280             


Asn Lys  Leu Thr Asn Lys Leu  Pro Asp Leu Trp Arg  Lys Ile Glu 
    2285                 2290                 2295             


Ser Ile  Asn Gln Gln Leu Leu  Pro Leu Gly Asn Ile  Ser Asp Asn 
    2300                 2305                 2310             


Met Asp  Arg Ile Arg Glu Leu  Ile Gln Gln Ala Arg  Asp Ala Ala 
    2315                 2320                 2325             


Ser Lys  Val Ala Val Pro Met  Arg Phe Asn Gly Lys  Ser Gly Val 
    2330                 2335                 2340             


Glu Val  Arg Leu Pro Asn Asp  Leu Glu Asp Leu Lys  Gly Tyr Thr 
    2345                 2350                 2355             


Ser Leu  Ser Leu Phe Leu Gln  Arg Pro Asn Ser Arg  Glu Asn Gly 
    2360                 2365                 2370             


Gly Thr  Glu Asn Met Phe Val  Met Tyr Leu Gly Asn  Lys Asp Ala 
    2375                 2380                 2385             


Ser Arg  Asp Tyr Ile Gly Met  Ala Val Val Asp Gly  Gln Leu Thr 
    2390                 2395                 2400             


Cys Val  Tyr Asn Leu Gly Asp  Arg Glu Ala Glu Leu  Gln Val Asp 
    2405                 2410                 2415             


Gln Ile  Leu Thr Lys Ser Glu  Thr Lys Glu Ala Val  Met Asp Arg 
    2420                 2425                 2430             


Val Lys  Phe Gln Arg Ile Tyr  Gln Phe Ala Arg Leu  Asn Tyr Thr 
    2435                 2440                 2445             


Lys Gly  Ala Thr Ser Ser Lys  Pro Glu Thr Pro Gly  Val Tyr Asp 
    2450                 2455                 2460             


Met Asp  Gly Arg Asn Ser Asn  Thr Leu Leu Asn Leu  Asp Pro Glu 
    2465                 2470                 2475             


Asn Val  Val Phe Tyr Val Gly  Gly Tyr Pro Pro Asp  Phe Lys Leu 
    2480                 2485                 2490             


Pro Ser  Arg Leu Ser Phe Pro  Pro Tyr Lys Gly Cys  Ile Glu Leu 
    2495                 2500                 2505             


Asp Asp  Leu Asn Glu Asn Val  Leu Ser Leu Tyr Asn  Phe Lys Lys 
    2510                 2515                 2520             


Thr Phe  Asn Leu Asn Thr Thr  Glu Val Glu Pro Cys  Arg Arg Arg 
    2525                 2530                 2535             


Lys Glu  Glu Ser Asp Lys Asn  Tyr Phe Glu Gly Thr  Gly Tyr Ala 
    2540                 2545                 2550             


Arg Val  Pro Thr Gln Pro His  Ala Pro Ile Pro Thr  Phe Gly Gln 
    2555                 2560                 2565             


Thr Ile  Gln Thr Thr Val Asp  Arg Gly Leu Leu Phe  Phe Ala Glu 
    2570                 2575                 2580             


Asn Gly  Asp Arg Phe Ile Ser  Leu Asn Ile Glu Asp  Gly Lys Leu 
    2585                 2590                 2595             


Met Val  Arg Tyr Lys Leu Asn  Ser Glu Leu Pro Lys  Glu Arg Gly 
    2600                 2605                 2610             


Val Gly  Asp Ala Ile Asn Asn  Gly Arg Asp His Ser  Ile Gln Ile 
    2615                 2620                 2625             


Lys Ile  Gly Lys Leu Gln Lys  Arg Met Trp Ile Asn  Val Asp Val 
    2630                 2635                 2640             


Gln Asn  Thr Ile Ile Asp Gly  Glu Val Phe Asp Phe  Ser Thr Tyr 
    2645                 2650                 2655             


Tyr Leu  Gly Gly Ile Pro Ile  Ala Ile Arg Glu Arg  Phe Asn Ile 
    2660                 2665                 2670             


Ser Thr  Pro Ala Phe Arg Gly  Cys Met Lys Asn Leu  Lys Lys Thr 
    2675                 2680                 2685             


Ser Gly  Val Val Arg Leu Asn  Asp Thr Val Gly Val  Thr Lys Lys 
    2690                 2695                 2700             


Cys Ser  Glu Asp Trp Lys Leu  Val Arg Ser Ala Ser  Phe Ser Arg 
    2705                 2710                 2715             


Gly Gly  Gln Leu Ser Phe Thr  Asp Leu Gly Leu Pro  Pro Thr Asp 
    2720                 2725                 2730             


His Leu  Gln Ala Ser Phe Gly  Phe Gln Thr Phe Gln  Pro Ser Gly 
    2735                 2740                 2745             


Ile Leu  Leu Asp His Gln Thr  Trp Thr Arg Asn Leu  Gln Val Thr 
    2750                 2755                 2760             


Leu Glu  Asp Gly Tyr Ile Glu  Leu Ser Thr Ser Asp  Ser Gly Gly 
    2765                 2770                 2775             


Pro Ile  Phe Lys Ser Pro Gln  Thr Tyr Met Asp Gly  Leu Leu His 
    2780                 2785                 2790             


Tyr Val  Ser Val Ile Ser Asp  Asn Ser Gly Leu Arg  Leu Leu Ile 
    2795                 2800                 2805             


Asp Asp  Gln Leu Leu Arg Asn  Ser Lys Arg Leu Lys  His Ile Ser 
    2810                 2815                 2820             


Ser Ser  Arg Gln Ser Leu Arg  Leu Gly Gly Ser Asn  Phe Glu Gly 
    2825                 2830                 2835             


Cys Ile  Ser Asn Val Phe Val  Gln Arg Leu Ser Leu  Ser Pro Glu 
    2840                 2845                 2850             


Val Leu  Asp Leu Thr Ser Asn  Ser Leu Lys Arg Asp  Val Ser Leu 
    2855                 2860                 2865             


Gly Gly  Cys Ser Leu Asn Lys  Pro Pro Phe Leu Met  Leu Leu Lys 
    2870                 2875                 2880             


Gly Ser  Thr Arg Phe Asn Lys  Thr Lys Thr Phe Arg  Ile Asn Gln 
    2885                 2890                 2895             


Leu Leu  Gln Asp Thr Pro Val  Ala Ser Pro Arg Ser  Val Lys Val 
    2900                 2905                 2910             


Trp Gln  Asp Ala Cys Ser Pro  Leu Pro Lys Thr Gln  Ala Asn His 
    2915                 2920                 2925             


Gly Ala  Leu Gln Phe Gly Asp  Ile Pro Thr Ser His  Leu Leu Phe 
    2930                 2935                 2940             


Lys Leu  Pro Gln Glu Leu Leu  Lys Pro Arg Ser Gln  Phe Ala Val 
    2945                 2950                 2955             


Asp Met  Gln Thr Thr Ser Ser  Arg Gly Leu Val Phe  His Thr Gly 
    2960                 2965                 2970             


Thr Lys  Asn Ser Phe Met Ala  Leu Tyr Leu Ser Lys  Gly Arg Leu 
    2975                 2980                 2985             


Val Phe  Ala Leu Gly Thr Asp  Gly Lys Lys Leu Arg  Ile Lys Ser 
    2990                 2995                 3000             


Lys Glu  Lys Cys Asn Asp Gly  Lys Trp His Thr Val  Val Phe Gly 
    3005                 3010                 3015             


His Asp  Gly Glu Lys Gly Arg  Leu Val Val Asp Gly  Leu Arg Ala 
    3020                 3025                 3030             


Arg Glu  Gly Ser Leu Pro Gly  Asn Ser Thr Ile Ser  Ile Arg Ala 
    3035                 3040                 3045             


Pro Val  Tyr Leu Gly Ser Pro  Pro Ser Gly Lys Pro  Lys Ser Leu 
    3050                 3055                 3060             


Pro Thr  Asn Ser Phe Val Gly  Cys Leu Lys Asn Phe  Gln Leu Asp 
    3065                 3070                 3075             


Ser Lys  Pro Leu Tyr Thr Pro  Ser Ser Ser Phe Gly  Val Ser Ser 
    3080                 3085                 3090             


Cys Leu  Gly Gly Pro Leu Glu  Lys Gly Ile Tyr Phe  Ser Glu Glu 
    3095                 3100                 3105             


Gly Gly  His Val Val Leu Ala  His Ser Val Leu Leu  Gly Pro Glu 
    3110                 3115                 3120             


Phe Lys  Leu Val Phe Ser Ile  Arg Pro Arg Ser Leu  Thr Gly Ile 
    3125                 3130                 3135             


Leu Ile  His Ile Gly Ser Gln  Pro Gly Lys His Leu  Cys Val Tyr 
    3140                 3145                 3150             


Leu Glu  Ala Gly Lys Val Thr  Ala Ser Met Asp Ser  Gly Ala Gly 
    3155                 3160                 3165             


Gly Thr  Ser Thr Ser Val Thr  Pro Lys Gln Ser Leu  Cys Asp Gly 
    3170                 3175                 3180             


Gln Trp  His Ser Val Ala Val  Thr Ile Lys Gln His  Ile Leu His 
    3185                 3190                 3195             


Leu Glu  Leu Asp Thr Asp Ser  Ser Tyr Thr Ala Gly  Gln Ile Pro 
    3200                 3205                 3210             


Phe Pro  Pro Ala Ser Thr Gln  Glu Pro Leu His Leu  Gly Gly Ala 
    3215                 3220                 3225             


Pro Ala  Asn Leu Thr Thr Leu  Arg Ile Pro Val Trp  Lys Ser Phe 
    3230                 3235                 3240             


Phe Gly  Cys Leu Arg Asn Ile  His Val Asn His Ile  Pro Val Pro 
    3245                 3250                 3255             


Val Thr  Glu Ala Leu Glu Val  Gln Gly Pro Val Ser  Leu Asn Gly 
    3260                 3265                 3270             


Cys Pro  Asp Gln 
    3275         


<210>  7650
<211>  576
<212>  PRT
<213>  Homo Sapiens

<400>  7650

Met Ala Ala Ala Ala Arg Pro Arg Gly Arg Ala Leu Gly Pro Val Leu 
1               5                   10                  15      


Pro Pro Thr Pro Leu Leu Leu Leu Val Leu Arg Val Leu Pro Ala Cys 
            20                  25                  30          


Gly Ala Thr Ala Arg Asp Pro Gly Ala Ala Ala Gly Leu Ser Leu His 
        35                  40                  45              


Pro Thr Tyr Phe Asn Leu Ala Glu Ala Ala Arg Ile Trp Ala Thr Ala 
    50                  55                  60                  


Thr Cys Gly Glu Arg Gly Pro Gly Glu Gly Arg Pro Gln Pro Glu Leu 
65                  70                  75                  80  


Tyr Cys Lys Leu Val Gly Gly Pro Thr Ala Pro Gly Ser Gly His Thr 
                85                  90                  95      


Ile Gln Gly Gln Phe Cys Asp Tyr Cys Asn Ser Glu Asp Pro Arg Lys 
            100                 105                 110         


Ala His Pro Val Thr Asn Ala Ile Asp Gly Ser Glu Arg Trp Trp Gln 
        115                 120                 125             


Ser Pro Pro Leu Ser Ser Gly Thr Gln Tyr Asn Arg Val Asn Leu Thr 
    130                 135                 140                 


Leu Asp Leu Gly Gln Leu Phe His Val Ala Tyr Ile Leu Ile Lys Phe 
145                 150                 155                 160 


Ala Asn Ser Pro Arg Pro Asp Leu Trp Val Leu Glu Arg Ser Val Asp 
                165                 170                 175     


Phe Gly Ser Thr Tyr Ser Pro Trp Gln Tyr Phe Ala His Ser Lys Val 
            180                 185                 190         


Asp Cys Leu Lys Glu Phe Gly Arg Glu Ala Asn Met Ala Val Thr Arg 
        195                 200                 205             


Asp Asp Asp Val Leu Cys Val Thr Glu Tyr Ser Arg Ile Val Pro Leu 
    210                 215                 220                 


Glu Asn Gly Glu Val Val Val Ser Leu Ile Asn Gly Arg Pro Gly Ala 
225                 230                 235                 240 


Lys Asn Phe Thr Phe Ser His Thr Leu Arg Glu Phe Thr Lys Ala Thr 
                245                 250                 255     


Asn Ile Arg Leu Arg Phe Leu Arg Thr Asn Thr Leu Leu Gly His Leu 
            260                 265                 270         


Ile Ser Lys Ala Gln Arg Asp Pro Thr Val Thr Arg Arg Tyr Tyr Tyr 
        275                 280                 285             


Ser Ile Lys Asp Ile Ser Ile Gly Gly Gln Cys Val Cys Asn Gly His 
    290                 295                 300                 


Ala Glu Val Cys Asn Ile Asn Asn Pro Glu Lys Leu Phe Arg Cys Glu 
305                 310                 315                 320 


Cys Gln His His Thr Cys Gly Glu Thr Cys Asp Arg Cys Cys Thr Gly 
                325                 330                 335     


Tyr Asn Gln Arg Arg Trp Arg Pro Ala Ala Trp Glu Gln Ser His Glu 
            340                 345                 350         


Cys Glu Ala Cys Asn Cys His Gly His Ala Ser Asn Cys Tyr Tyr Asp 
        355                 360                 365             


Pro Asp Val Glu Arg Gln Gln Ala Ser Leu Asn Thr Gln Gly Ile Tyr 
    370                 375                 380                 


Ala Gly Gly Gly Val Cys Ile Asn Cys Gln His Asn Thr Ala Gly Val 
385                 390                 395                 400 


Asn Cys Glu Gln Cys Ala Lys Gly Tyr Tyr Arg Pro Tyr Gly Val Pro 
                405                 410                 415     


Val Asp Ala Pro Asp Gly Cys Ile Pro Cys Ser Cys Asp Pro Glu His 
            420                 425                 430         


Ala Asp Gly Cys Glu Gln Gly Ser Gly Arg Cys His Cys Lys Pro Asn 
        435                 440                 445             


Phe His Gly Asp Asn Cys Glu Lys Cys Ala Ile Gly Tyr Tyr Asn Phe 
    450                 455                 460                 


Pro Phe Cys Leu Arg Ile Pro Ile Phe Pro Val Ser Thr Pro Ser Ser 
465                 470                 475                 480 


Glu Asp Pro Val Ala Gly Asp Ile Lys Gly Cys Asp Cys Asn Leu Glu 
                485                 490                 495     


Gly Val Leu Pro Glu Ile Cys Asp Ala His Gly Arg Cys Leu Cys Arg 
            500                 505                 510         


Pro Gly Val Glu Gly Pro Arg Cys Asp Thr Cys Arg Ser Gly Phe Tyr 
        515                 520                 525             


Ser Phe Pro Ile Cys Gln Gly Pro Ser Glu Lys Val Ala Ile Tyr Lys 
    530                 535                 540                 


Pro Glu Ser Arg Pro Ser Ala Glu Thr Glu Pro Ala Ser Thr Trp Ile 
545                 550                 555                 560 


Leu Asp Phe Pro Ala Ser Arg Thr Gly Glu Ile Asn Phe Tyr Cys Leu 
                565                 570                 575     


<210>  7651
<211>  1724
<212>  PRT
<213>  Homo Sapiens

<400>  7651

Met Pro Pro Ala Val Arg Arg Ser Ala Cys Ser Met Gly Trp Leu Trp 
1               5                   10                  15      


Ile Phe Gly Ala Ala Leu Gly Gln Cys Leu Gly Tyr Ser Ser Gln Gln 
            20                  25                  30          


Gln Arg Val Pro Phe Leu Gln Pro Pro Gly Gln Ser Gln Leu Gln Ala 
        35                  40                  45              


Ser Tyr Val Glu Phe Arg Pro Ser Gln Gly Cys Ser Pro Gly Tyr Tyr 
    50                  55                  60                  


Arg Asp His Lys Gly Leu Tyr Thr Gly Arg Cys Val Pro Cys Asn Cys 
65                  70                  75                  80  


Asn Gly His Ser Asn Gln Cys Gln Asp Gly Ser Gly Ile Cys Val Asn 
                85                  90                  95      


Cys Gln His Asn Thr Ala Gly Glu His Cys Glu Arg Cys Gln Glu Gly 
            100                 105                 110         


Tyr Tyr Gly Asn Ala Val His Gly Ser Cys Arg Ala Cys Pro Cys Pro 
        115                 120                 125             


His Thr Asn Ser Phe Ala Thr Gly Cys Val Val Asn Gly Gly Asp Val 
    130                 135                 140                 


Arg Cys Ser Cys Lys Ala Gly Tyr Thr Gly Thr Gln Cys Glu Arg Cys 
145                 150                 155                 160 


Ala Pro Gly Tyr Phe Gly Asn Pro Gln Lys Phe Gly Gly Ser Cys Gln 
                165                 170                 175     


Pro Cys Ser Cys Asn Ser Asn Gly Gln Leu Gly Ser Cys His Pro Leu 
            180                 185                 190         


Thr Gly Asp Cys Ile Asn Gln Glu Pro Lys Asp Ser Ser Pro Ala Glu 
        195                 200                 205             


Glu Cys Asp Asp Cys Asp Ser Cys Val Met Thr Leu Leu Asn Asp Leu 
    210                 215                 220                 


Ala Thr Met Gly Glu Gln Leu Arg Leu Val Lys Ser Gln Leu Gln Gly 
225                 230                 235                 240 


Leu Ser Ala Ser Ala Gly Leu Leu Glu Gln Met Arg His Met Glu Thr 
                245                 250                 255     


Gln Ala Lys Asp Leu Arg Asn Gln Leu Leu Asn Tyr Arg Ser Ala Ile 
            260                 265                 270         


Ser Asn His Gly Ser Lys Ile Glu Gly Leu Glu Arg Glu Leu Thr Asp 
        275                 280                 285             


Leu Asn Gln Glu Phe Glu Thr Leu Gln Glu Lys Ala Gln Val Asn Ser 
    290                 295                 300                 


Arg Lys Ala Gln Thr Leu Asn Asn Asn Val Asn Arg Ala Thr Gln Ser 
305                 310                 315                 320 


Ala Lys Glu Leu Asp Val Lys Ile Lys Asn Val Ile Arg Asn Val His 
                325                 330                 335     


Ile Leu Leu Lys Gln Ile Ser Gly Thr Asp Gly Glu Gly Asn Asn Val 
            340                 345                 350         


Pro Ser Gly Asp Phe Ser Arg Glu Trp Ala Glu Ala Gln Arg Met Met 
        355                 360                 365             


Arg Glu Leu Arg Asn Arg Asn Phe Gly Lys His Leu Arg Glu Ala Glu 
    370                 375                 380                 


Ala Asp Lys Arg Glu Ser Gln Leu Leu Leu Asn Arg Ile Arg Thr Trp 
385                 390                 395                 400 


Gln Lys Thr His Gln Gly Glu Asn Asn Gly Leu Ala Asn Ser Ile Arg 
                405                 410                 415     


Asp Ser Leu Asn Glu Tyr Glu Ala Lys Leu Ser Asp Leu Arg Ala Arg 
            420                 425                 430         


Leu Gln Glu Ala Ala Ala Gln Ala Lys Gln Ala Asn Gly Leu Asn Gln 
        435                 440                 445             


Glu Asn Glu Arg Ala Leu Gly Ala Ile Gln Arg Gln Val Lys Glu Ile 
    450                 455                 460                 


Asn Ser Leu Gln Ser Asp Phe Thr Lys Tyr Leu Thr Thr Ala Asp Ser 
465                 470                 475                 480 


Ser Leu Leu Gln Thr Asn Ile Ala Leu Gln Leu Met Glu Lys Ser Gln 
                485                 490                 495     


Lys Glu Tyr Glu Lys Leu Ala Ala Ser Leu Asn Glu Ala Arg Gln Glu 
            500                 505                 510         


Leu Ser Asp Lys Val Arg Glu Leu Ser Arg Ser Ala Gly Lys Thr Ser 
        515                 520                 525             


Leu Val Glu Glu Ala Glu Lys His Ala Arg Ser Leu Gln Glu Leu Ala 
    530                 535                 540                 


Lys Gln Leu Glu Glu Ile Lys Arg Asn Ala Ser Gly Asp Glu Leu Val 
545                 550                 555                 560 


Arg Cys Ala Val Asp Ala Ala Thr Ala Tyr Glu Asn Ile Leu Asn Ala 
                565                 570                 575     


Ile Lys Ala Ala Glu Asp Ala Ala Asn Arg Ala Ala Ser Ala Ser Glu 
            580                 585                 590         


Ser Ala Leu Gln Thr Val Ile Lys Glu Asp Leu Pro Arg Lys Ala Lys 
        595                 600                 605             


Thr Leu Ser Ser Asn Ser Asp Lys Leu Leu Asn Glu Ala Lys Met Thr 
    610                 615                 620                 


Gln Lys Lys Leu Lys Gln Glu Val Ser Pro Ala Leu Asn Asn Leu Gln 
625                 630                 635                 640 


Gln Thr Leu Asn Ile Val Thr Val Gln Lys Glu Val Ile Asp Thr Asn 
                645                 650                 655     


Leu Thr Thr Leu Arg Asp Gly Leu His Gly Ile Gln Arg Gly Asp Ile 
            660                 665                 670         


Asp Ala Met Ile Ser Ser Ala Lys Ser Met Val Arg Lys Ala Asn Asp 
        675                 680                 685             


Ile Thr Asp Glu Val Leu Asp Gly Leu Asn Pro Ile Gln Thr Asp Val 
    690                 695                 700                 


Glu Arg Ile Lys Asp Thr Tyr Gly Arg Thr Gln Asn Glu Asp Phe Lys 
705                 710                 715                 720 


Lys Ala Leu Thr Asp Ala Asp Asn Ser Val Asn Lys Leu Thr Asn Lys 
                725                 730                 735     


Leu Pro Asp Leu Trp Arg Lys Ile Glu Ser Ile Asn Gln Gln Leu Leu 
            740                 745                 750         


Pro Leu Gly Asn Ile Ser Asp Asn Met Asp Arg Ile Arg Glu Leu Ile 
        755                 760                 765             


Gln Gln Ala Arg Asp Ala Ala Ser Lys Val Ala Val Pro Met Arg Phe 
    770                 775                 780                 


Asn Gly Lys Ser Gly Val Glu Val Arg Leu Pro Asn Asp Leu Glu Asp 
785                 790                 795                 800 


Leu Lys Gly Tyr Thr Ser Leu Ser Leu Phe Leu Gln Arg Pro Asn Ser 
                805                 810                 815     


Arg Glu Asn Gly Gly Thr Glu Asn Met Phe Val Met Tyr Leu Gly Asn 
            820                 825                 830         


Lys Asp Ala Ser Arg Asp Tyr Ile Gly Met Ala Val Val Asp Gly Gln 
        835                 840                 845             


Leu Thr Cys Val Tyr Asn Leu Gly Asp Arg Glu Ala Glu Leu Gln Val 
    850                 855                 860                 


Asp Gln Ile Leu Thr Lys Ser Glu Thr Lys Glu Ala Val Met Asp Arg 
865                 870                 875                 880 


Val Lys Phe Gln Arg Ile Tyr Gln Phe Ala Arg Leu Asn Tyr Thr Lys 
                885                 890                 895     


Gly Ala Thr Ser Ser Lys Pro Glu Thr Pro Gly Val Tyr Asp Met Asp 
            900                 905                 910         


Gly Arg Asn Ser Asn Thr Leu Leu Asn Leu Asp Pro Glu Asn Val Val 
        915                 920                 925             


Phe Tyr Val Gly Gly Tyr Pro Pro Asp Phe Lys Leu Pro Ser Arg Leu 
    930                 935                 940                 


Ser Phe Pro Pro Tyr Lys Gly Cys Ile Glu Leu Asp Asp Leu Asn Glu 
945                 950                 955                 960 


Asn Val Leu Ser Leu Tyr Asn Phe Lys Lys Thr Phe Asn Leu Asn Thr 
                965                 970                 975     


Thr Glu Val Glu Pro Cys Arg Arg Arg Lys Glu Glu Ser Asp Lys Asn 
            980                 985                 990         


Tyr Phe Glu Gly Thr Gly Tyr Ala  Arg Val Pro Thr Gln  Pro His Ala 
        995                 1000                 1005             


Pro Ile  Pro Thr Phe Gly Gln  Thr Ile Gln Thr Thr  Val Asp Arg 
    1010                 1015                 1020             


Gly Leu  Leu Phe Phe Ala Glu  Asn Gly Asp Arg Phe  Ile Ser Leu 
    1025                 1030                 1035             


Asn Ile  Glu Asp Gly Lys Leu  Met Val Arg Tyr Lys  Leu Asn Ser 
    1040                 1045                 1050             


Glu Leu  Pro Lys Glu Arg Gly  Val Gly Asp Ala Ile  Asn Asn Gly 
    1055                 1060                 1065             


Arg Asp  His Ser Ile Gln Ile  Lys Ile Gly Lys Leu  Gln Lys Arg 
    1070                 1075                 1080             


Met Trp  Ile Asn Val Asp Val  Gln Asn Thr Ile Ile  Asp Gly Glu 
    1085                 1090                 1095             


Val Phe  Asp Phe Ser Thr Tyr  Tyr Leu Gly Gly Ile  Pro Ile Ala 
    1100                 1105                 1110             


Ile Arg  Glu Arg Phe Asn Ile  Ser Thr Pro Ala Phe  Arg Gly Cys 
    1115                 1120                 1125             


Met Lys  Asn Leu Lys Lys Thr  Ser Gly Val Val Arg  Leu Asn Asp 
    1130                 1135                 1140             


Thr Val  Gly Val Thr Lys Lys  Cys Ser Glu Asp Trp  Lys Leu Val 
    1145                 1150                 1155             


Arg Ser  Ala Ser Phe Ser Arg  Gly Gly Gln Leu Ser  Phe Thr Asp 
    1160                 1165                 1170             


Leu Gly  Leu Pro Pro Thr Asp  His Leu Gln Ala Ser  Phe Gly Phe 
    1175                 1180                 1185             


Gln Thr  Phe Gln Pro Ser Gly  Ile Leu Leu Asp His  Gln Thr Trp 
    1190                 1195                 1200             


Thr Arg  Asn Leu Gln Val Thr  Leu Glu Asp Gly Tyr  Ile Glu Leu 
    1205                 1210                 1215             


Ser Thr  Ser Asp Ser Gly Gly  Pro Ile Phe Lys Ser  Pro Gln Thr 
    1220                 1225                 1230             


Tyr Met  Asp Gly Leu Leu His  Tyr Val Ser Val Ile  Ser Asp Asn 
    1235                 1240                 1245             


Ser Gly  Leu Arg Leu Leu Ile  Asp Asp Gln Leu Leu  Arg Asn Ser 
    1250                 1255                 1260             


Lys Arg  Leu Lys His Ile Ser  Ser Ser Arg Gln Ser  Leu Arg Leu 
    1265                 1270                 1275             


Gly Gly  Ser Asn Phe Glu Gly  Cys Ile Ser Asn Val  Phe Val Gln 
    1280                 1285                 1290             


Arg Leu  Ser Leu Ser Pro Glu  Val Leu Asp Leu Thr  Ser Asn Ser 
    1295                 1300                 1305             


Leu Lys  Arg Asp Val Ser Leu  Gly Gly Cys Ser Leu  Asn Lys Pro 
    1310                 1315                 1320             


Pro Phe  Leu Met Leu Leu Lys  Gly Ser Thr Arg Phe  Asn Lys Thr 
    1325                 1330                 1335             


Lys Thr  Phe Arg Ile Asn Gln  Leu Leu Gln Asp Thr  Pro Val Ala 
    1340                 1345                 1350             


Ser Pro  Arg Ser Val Lys Val  Trp Gln Asp Ala Cys  Ser Pro Leu 
    1355                 1360                 1365             


Pro Lys  Thr Gln Ala Asn His  Gly Ala Leu Gln Phe  Gly Asp Ile 
    1370                 1375                 1380             


Pro Thr  Ser His Leu Leu Phe  Lys Leu Pro Gln Glu  Leu Leu Lys 
    1385                 1390                 1395             


Pro Arg  Ser Gln Phe Ala Val  Asp Met Gln Thr Thr  Ser Ser Arg 
    1400                 1405                 1410             


Gly Leu  Val Phe His Thr Gly  Thr Lys Asn Ser Phe  Met Ala Leu 
    1415                 1420                 1425             


Tyr Leu  Ser Lys Gly Arg Leu  Val Phe Ala Leu Gly  Thr Asp Gly 
    1430                 1435                 1440             


Lys Lys  Leu Arg Ile Lys Ser  Lys Glu Lys Cys Asn  Asp Gly Lys 
    1445                 1450                 1455             


Trp His  Thr Val Val Phe Gly  His Asp Gly Glu Lys  Gly Arg Leu 
    1460                 1465                 1470             


Val Val  Asp Gly Leu Arg Ala  Arg Glu Gly Ser Leu  Pro Gly Asn 
    1475                 1480                 1485             


Ser Thr  Ile Ser Ile Arg Ala  Pro Val Tyr Leu Gly  Ser Pro Pro 
    1490                 1495                 1500             


Ser Gly  Lys Pro Lys Ser Leu  Pro Thr Asn Ser Phe  Val Gly Cys 
    1505                 1510                 1515             


Leu Lys  Asn Phe Gln Leu Asp  Ser Lys Pro Leu Tyr  Thr Pro Ser 
    1520                 1525                 1530             


Ser Ser  Phe Gly Val Ser Ser  Cys Leu Gly Gly Pro  Leu Glu Lys 
    1535                 1540                 1545             


Gly Ile  Tyr Phe Ser Glu Glu  Gly Gly His Val Val  Leu Ala His 
    1550                 1555                 1560             


Ser Val  Leu Leu Gly Pro Glu  Phe Lys Leu Val Phe  Ser Ile Arg 
    1565                 1570                 1575             


Pro Arg  Ser Leu Thr Gly Ile  Leu Ile His Ile Gly  Ser Gln Pro 
    1580                 1585                 1590             


Gly Lys  His Leu Cys Val Tyr  Leu Glu Ala Gly Lys  Val Thr Ala 
    1595                 1600                 1605             


Ser Met  Asp Ser Gly Ala Gly  Gly Thr Ser Thr Ser  Val Thr Pro 
    1610                 1615                 1620             


Lys Gln  Ser Leu Cys Asp Gly  Gln Trp His Ser Val  Ala Val Thr 
    1625                 1630                 1635             


Ile Lys  Gln His Ile Leu His  Leu Glu Leu Asp Thr  Asp Ser Ser 
    1640                 1645                 1650             


Tyr Thr  Ala Gly Gln Ile Pro  Phe Pro Pro Ala Ser  Thr Gln Glu 
    1655                 1660                 1665             


Pro Leu  His Leu Gly Gly Ala  Pro Ala Asn Leu Thr  Thr Leu Arg 
    1670                 1675                 1680             


Ile Pro  Val Trp Lys Ser Phe  Phe Gly Cys Leu Arg  Asn Ile His 
    1685                 1690                 1695             


Val Asn  His Ile Pro Val Pro  Val Thr Glu Ala Leu  Glu Val Gln 
    1700                 1705                 1710             


Gly Pro  Val Ser Leu Asn Gly  Cys Pro Asp Gln 
    1715                 1720                 


<210>  7652
<211>  1668
<212>  PRT
<213>  Homo Sapiens

<400>  7652

Met Pro Pro Ala Val Arg Arg Ser Ala Cys Ser Met Gly Trp Leu Trp 
1               5                   10                  15      


Ile Phe Gly Ala Ala Leu Gly Gln Cys Leu Gly Tyr Ser Ser Gln Gln 
            20                  25                  30          


Gln Arg Val Pro Phe Leu Gln Pro Pro Gly Gln Ser Gln Leu Gln Ala 
        35                  40                  45              


Ser Tyr Val Glu Phe Arg Pro Ser Gln Gly Cys Ser Pro Gly Tyr Tyr 
    50                  55                  60                  


Arg Asp His Lys Gly Leu Tyr Thr Gly Arg Cys Val Pro Cys Asn Cys 
65                  70                  75                  80  


Asn Gly His Ser Asn Gln Cys Gln Asp Gly Ser Gly Ile Cys Val Asn 
                85                  90                  95      


Cys Gln His Asn Thr Ala Gly Glu His Cys Glu Arg Cys Gln Glu Gly 
            100                 105                 110         


Tyr Tyr Gly Asn Ala Val His Gly Ser Cys Arg Ala Cys Pro Cys Pro 
        115                 120                 125             


His Thr Asn Ser Phe Ala Thr Gly Cys Val Val Asn Gly Gly Asp Val 
    130                 135                 140                 


Arg Cys Ser Cys Lys Ala Gly Tyr Thr Gly Thr Gln Cys Glu Arg Cys 
145                 150                 155                 160 


Ala Pro Gly Tyr Phe Gly Asn Pro Gln Lys Phe Gly Gly Ser Cys Gln 
                165                 170                 175     


Pro Cys Ser Cys Asn Ser Asn Gly Gln Leu Gly Ser Cys His Pro Leu 
            180                 185                 190         


Thr Gly Asp Cys Ile Asn Gln Glu Pro Lys Asp Ser Ser Pro Ala Glu 
        195                 200                 205             


Glu Cys Asp Asp Cys Asp Ser Cys Val Met Thr Leu Leu Asn Asp Leu 
    210                 215                 220                 


Ala Thr Met Gly Glu Gln Leu Arg Leu Val Lys Ser Gln Leu Gln Gly 
225                 230                 235                 240 


Leu Ser Ala Ser Ala Gly Leu Leu Glu Gln Met Arg His Met Glu Thr 
                245                 250                 255     


Gln Ala Lys Asp Leu Arg Asn Gln Leu Leu Asn Tyr Arg Ser Ala Ile 
            260                 265                 270         


Ser Asn His Gly Ser Lys Ile Glu Gly Leu Glu Arg Glu Leu Thr Asp 
        275                 280                 285             


Leu Asn Gln Glu Phe Glu Thr Leu Gln Glu Lys Ala Gln Val Asn Ser 
    290                 295                 300                 


Arg Lys Ala Gln Thr Leu Asn Asn Asn Val Asn Arg Ala Thr Gln Ser 
305                 310                 315                 320 


Ala Lys Glu Leu Asp Val Lys Ile Lys Asn Val Ile Arg Asn Val His 
                325                 330                 335     


Met Leu Asn Arg Ile Arg Thr Trp Gln Lys Thr His Gln Gly Glu Asn 
            340                 345                 350         


Asn Gly Leu Ala Asn Ser Ile Arg Asp Ser Leu Asn Glu Tyr Glu Ala 
        355                 360                 365             


Lys Leu Ser Asp Leu Arg Ala Arg Leu Gln Glu Ala Ala Ala Gln Ala 
    370                 375                 380                 


Lys Gln Ala Asn Gly Leu Asn Gln Glu Asn Glu Arg Ala Leu Gly Ala 
385                 390                 395                 400 


Ile Gln Arg Gln Val Lys Glu Ile Asn Ser Leu Gln Ser Asp Phe Thr 
                405                 410                 415     


Lys Tyr Leu Thr Thr Ala Asp Ser Ser Leu Leu Gln Thr Asn Ile Ala 
            420                 425                 430         


Leu Gln Leu Met Glu Lys Ser Gln Lys Glu Tyr Glu Lys Leu Ala Ala 
        435                 440                 445             


Ser Leu Asn Glu Ala Arg Gln Glu Leu Ser Asp Lys Val Arg Glu Leu 
    450                 455                 460                 


Ser Arg Ser Ala Gly Lys Thr Ser Leu Val Glu Glu Ala Glu Lys His 
465                 470                 475                 480 


Ala Arg Ser Leu Gln Glu Leu Ala Lys Gln Leu Glu Glu Ile Lys Arg 
                485                 490                 495     


Asn Ala Ser Gly Asp Glu Leu Val Arg Cys Ala Val Asp Ala Ala Thr 
            500                 505                 510         


Ala Tyr Glu Asn Ile Leu Asn Ala Ile Lys Ala Ala Glu Asp Ala Ala 
        515                 520                 525             


Asn Arg Ala Ala Ser Ala Ser Glu Ser Ala Leu Gln Thr Val Ile Lys 
    530                 535                 540                 


Glu Asp Leu Pro Arg Lys Ala Lys Thr Leu Ser Ser Asn Ser Asp Lys 
545                 550                 555                 560 


Leu Leu Asn Glu Ala Lys Met Thr Gln Lys Lys Leu Lys Gln Glu Val 
                565                 570                 575     


Ser Pro Ala Leu Asn Asn Leu Gln Gln Thr Leu Asn Ile Val Thr Val 
            580                 585                 590         


Gln Lys Glu Val Ile Asp Thr Asn Leu Thr Thr Leu Arg Asp Gly Leu 
        595                 600                 605             


His Gly Ile Gln Arg Gly Asp Ile Asp Ala Met Ile Ser Ser Ala Lys 
    610                 615                 620                 


Ser Met Val Arg Lys Ala Asn Asp Ile Thr Asp Glu Val Leu Asp Gly 
625                 630                 635                 640 


Leu Asn Pro Ile Gln Thr Asp Val Glu Arg Ile Lys Asp Thr Tyr Gly 
                645                 650                 655     


Arg Thr Gln Asn Glu Asp Phe Lys Lys Ala Leu Thr Asp Ala Asp Asn 
            660                 665                 670         


Ser Val Asn Lys Leu Thr Asn Lys Leu Pro Asp Leu Trp Arg Lys Ile 
        675                 680                 685             


Glu Ser Ile Asn Gln Gln Leu Leu Pro Leu Gly Asn Ile Ser Asp Asn 
    690                 695                 700                 


Met Asp Arg Ile Arg Glu Leu Ile Gln Gln Ala Arg Asp Ala Ala Ser 
705                 710                 715                 720 


Lys Val Ala Val Pro Met Arg Phe Asn Gly Lys Ser Gly Val Glu Val 
                725                 730                 735     


Arg Leu Pro Asn Asp Leu Glu Asp Leu Lys Gly Tyr Thr Ser Leu Ser 
            740                 745                 750         


Leu Phe Leu Gln Arg Pro Asn Ser Arg Glu Asn Gly Gly Thr Glu Asn 
        755                 760                 765             


Met Phe Val Met Tyr Leu Gly Asn Lys Asp Ala Ser Arg Asp Tyr Ile 
    770                 775                 780                 


Gly Met Ala Val Val Asp Gly Gln Leu Thr Cys Val Tyr Asn Leu Gly 
785                 790                 795                 800 


Asp Arg Glu Ala Glu Leu Gln Val Asp Gln Ile Leu Thr Lys Ser Glu 
                805                 810                 815     


Thr Lys Glu Ala Val Met Asp Arg Val Lys Phe Gln Arg Ile Tyr Gln 
            820                 825                 830         


Phe Ala Arg Leu Asn Tyr Thr Lys Gly Ala Thr Ser Ser Lys Pro Glu 
        835                 840                 845             


Thr Pro Gly Val Tyr Asp Met Asp Gly Arg Asn Ser Asn Thr Leu Leu 
    850                 855                 860                 


Asn Leu Asp Pro Glu Asn Val Val Phe Tyr Val Gly Gly Tyr Pro Pro 
865                 870                 875                 880 


Asp Phe Lys Leu Pro Ser Arg Leu Ser Phe Pro Pro Tyr Lys Gly Cys 
                885                 890                 895     


Ile Glu Leu Asp Asp Leu Asn Glu Asn Val Leu Ser Leu Tyr Asn Phe 
            900                 905                 910         


Lys Lys Thr Phe Asn Leu Asn Thr Thr Glu Val Glu Pro Cys Arg Arg 
        915                 920                 925             


Arg Lys Glu Glu Ser Asp Lys Asn Tyr Phe Glu Gly Thr Gly Tyr Ala 
    930                 935                 940                 


Arg Val Pro Thr Gln Pro His Ala Pro Ile Pro Thr Phe Gly Gln Thr 
945                 950                 955                 960 


Ile Gln Thr Thr Val Asp Arg Gly Leu Leu Phe Phe Ala Glu Asn Gly 
                965                 970                 975     


Asp Arg Phe Ile Ser Leu Asn Ile Glu Asp Gly Lys Leu Met Val Arg 
            980                 985                 990         


Tyr Lys Leu Asn Ser Glu Leu Pro  Lys Glu Arg Gly Val  Gly Asp Ala 
        995                 1000                 1005             


Ile Asn  Asn Gly Arg Asp His  Ser Ile Gln Ile Lys  Ile Gly Lys 
    1010                 1015                 1020             


Leu Gln  Lys Arg Met Trp Ile  Asn Val Asp Val Gln  Asn Thr Ile 
    1025                 1030                 1035             


Ile Asp  Gly Glu Val Phe Asp  Phe Ser Thr Tyr Tyr  Leu Gly Gly 
    1040                 1045                 1050             


Ile Pro  Ile Ala Ile Arg Glu  Arg Phe Asn Ile Ser  Thr Pro Ala 
    1055                 1060                 1065             


Phe Arg  Gly Cys Met Lys Asn  Leu Lys Lys Thr Ser  Gly Val Val 
    1070                 1075                 1080             


Arg Leu  Asn Asp Thr Val Gly  Val Thr Lys Lys Cys  Ser Glu Asp 
    1085                 1090                 1095             


Trp Lys  Leu Val Arg Ser Ala  Ser Phe Ser Arg Gly  Gly Gln Leu 
    1100                 1105                 1110             


Ser Phe  Thr Asp Leu Gly Leu  Pro Pro Thr Asp His  Leu Gln Ala 
    1115                 1120                 1125             


Ser Phe  Gly Phe Gln Thr Phe  Gln Pro Ser Gly Ile  Leu Leu Asp 
    1130                 1135                 1140             


His Gln  Thr Trp Thr Arg Asn  Leu Gln Val Thr Leu  Glu Asp Gly 
    1145                 1150                 1155             


Tyr Ile  Glu Leu Ser Thr Ser  Asp Ser Gly Gly Pro  Ile Phe Lys 
    1160                 1165                 1170             


Ser Pro  Gln Thr Tyr Met Asp  Gly Leu Leu His Tyr  Val Ser Val 
    1175                 1180                 1185             


Ile Ser  Asp Asn Ser Gly Leu  Arg Leu Leu Ile Asp  Asp Gln Leu 
    1190                 1195                 1200             


Leu Arg  Asn Ser Lys Arg Leu  Lys His Ile Ser Ser  Ser Arg Gln 
    1205                 1210                 1215             


Ser Leu  Arg Leu Gly Gly Ser  Asn Phe Glu Gly Cys  Ile Ser Asn 
    1220                 1225                 1230             


Val Phe  Val Gln Arg Leu Ser  Leu Ser Pro Glu Val  Leu Asp Leu 
    1235                 1240                 1245             


Thr Ser  Asn Ser Leu Lys Arg  Asp Val Ser Leu Gly  Gly Cys Ser 
    1250                 1255                 1260             


Leu Asn  Lys Pro Pro Phe Leu  Met Leu Leu Lys Gly  Ser Thr Arg 
    1265                 1270                 1275             


Phe Asn  Lys Thr Lys Thr Phe  Arg Ile Asn Gln Leu  Leu Gln Asp 
    1280                 1285                 1290             


Thr Pro  Val Ala Ser Pro Arg  Ser Val Lys Val Trp  Gln Asp Ala 
    1295                 1300                 1305             


Cys Ser  Pro Leu Pro Lys Thr  Gln Ala Asn His Gly  Ala Leu Gln 
    1310                 1315                 1320             


Phe Gly  Asp Ile Pro Thr Ser  His Leu Leu Phe Lys  Leu Pro Gln 
    1325                 1330                 1335             


Glu Leu  Leu Lys Pro Arg Ser  Gln Phe Ala Val Asp  Met Gln Thr 
    1340                 1345                 1350             


Thr Ser  Ser Arg Gly Leu Val  Phe His Thr Gly Thr  Lys Asn Ser 
    1355                 1360                 1365             


Phe Met  Ala Leu Tyr Leu Ser  Lys Gly Arg Leu Val  Phe Ala Leu 
    1370                 1375                 1380             


Gly Thr  Asp Gly Lys Lys Leu  Arg Ile Lys Ser Lys  Glu Lys Cys 
    1385                 1390                 1395             


Asn Asp  Gly Lys Trp His Thr  Val Val Phe Gly His  Asp Gly Glu 
    1400                 1405                 1410             


Lys Gly  Arg Leu Val Val Asp  Gly Leu Arg Ala Arg  Glu Gly Ser 
    1415                 1420                 1425             


Leu Pro  Gly Asn Ser Thr Ile  Ser Ile Arg Ala Pro  Val Tyr Leu 
    1430                 1435                 1440             


Gly Ser  Pro Pro Ser Gly Lys  Pro Lys Ser Leu Pro  Thr Asn Ser 
    1445                 1450                 1455             


Phe Val  Gly Cys Leu Lys Asn  Phe Gln Leu Asp Ser  Lys Pro Leu 
    1460                 1465                 1470             


Tyr Thr  Pro Ser Ser Ser Phe  Gly Val Ser Ser Cys  Leu Gly Gly 
    1475                 1480                 1485             


Pro Leu  Glu Lys Gly Ile Tyr  Phe Ser Glu Glu Gly  Gly His Val 
    1490                 1495                 1500             


Val Leu  Ala His Ser Val Leu  Leu Gly Pro Glu Phe  Lys Leu Val 
    1505                 1510                 1515             


Phe Ser  Ile Arg Pro Arg Ser  Leu Thr Gly Ile Leu  Ile His Ile 
    1520                 1525                 1530             


Gly Ser  Gln Pro Gly Lys His  Leu Cys Val Tyr Leu  Glu Ala Gly 
    1535                 1540                 1545             


Lys Val  Thr Ala Ser Met Asp  Ser Gly Ala Gly Gly  Thr Ser Thr 
    1550                 1555                 1560             


Ser Val  Thr Pro Lys Gln Ser  Leu Cys Asp Gly Gln  Trp His Ser 
    1565                 1570                 1575             


Val Ala  Val Thr Ile Lys Gln  His Ile Leu His Leu  Glu Leu Asp 
    1580                 1585                 1590             


Thr Asp  Ser Ser Tyr Thr Ala  Gly Gln Ile Pro Phe  Pro Pro Ala 
    1595                 1600                 1605             


Ser Thr  Gln Glu Pro Leu His  Leu Gly Gly Ala Pro  Ala Asn Leu 
    1610                 1615                 1620             


Thr Thr  Leu Arg Ile Pro Val  Trp Lys Ser Phe Phe  Gly Cys Leu 
    1625                 1630                 1635             


Arg Asn  Ile His Val Asn His  Ile Pro Val Pro Val  Thr Glu Ala 
    1640                 1645                 1650             


Leu Glu  Val Gln Gly Pro Val  Ser Leu Asn Gly Cys  Pro Asp Gln 
    1655                 1660                 1665             


<210>  7653
<211>  59
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7653

Xaa Ala Gly Gln Val Asn Ile Tyr Ser Cys Asn Tyr Arg Cys Asp Ala 
1               5                   10                  15      


Met Asn Ser Leu Leu Ser Pro Gln Arg Leu Cys Gln Val Pro Gly Cys 
            20                  25                  30          


Ile Ala Gln Gly Lys Arg Leu Ile Leu Ser Asn Val Arg Gly Cys Thr 
        35                  40                  45              


Pro Thr Phe Ala Thr His Leu Gln Asn Trp Gly 
    50                  55                  


<210>  7654
<211>  1147
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7654

Xaa Phe Ala Thr Gly Cys Val Val Asn Gly Gly Asp Val Arg Cys Ser 
1               5                   10                  15      


Cys Lys Ala Gly Tyr Thr Gly Thr Gln Cys Glu Arg Cys Ala Pro Gly 
            20                  25                  30          


Tyr Phe Gly Asn Pro Gln Lys Phe Gly Gly Ser Cys Gln Pro Cys Ser 
        35                  40                  45              


Cys Asn Ser Asn Gly Gln Leu Gly Ser Cys His Pro Leu Thr Gly Asp 
    50                  55                  60                  


Cys Ile Asn Gln Glu Pro Lys Asp Ser Ser Pro Ala Glu Glu Cys Asp 
65                  70                  75                  80  


Asp Cys Asp Ser Cys Val Met Thr Leu Leu Asn Asp Leu Ala Thr Met 
                85                  90                  95      


Gly Glu Gln Leu Arg Leu Val Lys Ser Gln Leu Gln Gly Leu Ser Ala 
            100                 105                 110         


Ser Ala Gly Leu Leu Glu Gln Met Arg His Met Glu Thr Gln Ala Lys 
        115                 120                 125             


Asp Leu Arg Asn Gln Leu Leu Asn Tyr Arg Ser Ala Ile Ser Asn His 
    130                 135                 140                 


Gly Ser Lys Ile Glu Gly Leu Glu Arg Glu Leu Thr Asp Leu Asn Gln 
145                 150                 155                 160 


Glu Phe Glu Thr Leu Gln Glu Lys Ala Gln Val Asn Ser Arg Lys Ala 
                165                 170                 175     


Gln Thr Leu Asn Asn Asn Val Asn Arg Ala Thr Gln Ser Ala Lys Glu 
            180                 185                 190         


Leu Asp Val Lys Ile Lys Asn Val Ile Arg Asn Val His Ile Leu Leu 
        195                 200                 205             


Lys Gln Ile Ser Gly Thr Asp Gly Glu Gly Asn Asn Val Pro Ser Gly 
    210                 215                 220                 


Asp Phe Ser Arg Glu Trp Ala Glu Ala Gln Arg Met Met Arg Glu Leu 
225                 230                 235                 240 


Arg Asn Arg Asn Phe Gly Lys His Leu Arg Glu Ala Glu Ala Asp Lys 
                245                 250                 255     


Arg Glu Ser Gln Leu Leu Leu Asn Arg Ile Arg Thr Trp Gln Lys Thr 
            260                 265                 270         


His Gln Gly Glu Asn Asn Gly Leu Ala Asn Ser Ile Arg Asp Ser Leu 
        275                 280                 285             


Asn Glu Tyr Glu Ala Lys Leu Ser Asp Leu Arg Ala Arg Leu Gln Glu 
    290                 295                 300                 


Ala Ala Ala Gln Ala Lys Gln Ala Asn Gly Leu Asn Gln Glu Asn Glu 
305                 310                 315                 320 


Arg Ala Leu Gly Ala Ile Gln Arg Gln Val Lys Glu Ile Asn Ser Leu 
                325                 330                 335     


Gln Ser Asp Phe Thr Lys Tyr Leu Thr Thr Ala Asp Ser Ser Leu Leu 
            340                 345                 350         


Gln Thr Asn Ile Ala Leu Gln Leu Met Glu Lys Ser Gln Lys Glu Tyr 
        355                 360                 365             


Glu Lys Leu Ala Ala Ser Leu Asn Glu Ala Arg Gln Glu Leu Ser Asp 
    370                 375                 380                 


Lys Val Arg Glu Leu Ser Arg Ser Ala Gly Lys Thr Ser Leu Val Glu 
385                 390                 395                 400 


Glu Ala Glu Lys His Ala Arg Ser Leu Gln Glu Leu Ala Lys Gln Leu 
                405                 410                 415     


Glu Glu Ile Lys Arg Asn Ala Ser Gly Asp Glu Leu Val Arg Cys Ala 
            420                 425                 430         


Val Asp Ala Ala Thr Ala Tyr Glu Asn Ile Leu Asn Ala Ile Lys Ala 
        435                 440                 445             


Ala Glu Asp Ala Ala Asn Arg Ala Ala Ser Ala Ser Glu Ser Ala Leu 
    450                 455                 460                 


Gln Thr Val Ile Lys Glu Asp Leu Pro Arg Lys Ala Lys Thr Leu Ser 
465                 470                 475                 480 


Ser Asn Ser Asp Lys Leu Leu Asn Glu Ala Lys Met Thr Gln Lys Lys 
                485                 490                 495     


Leu Lys Gln Glu Val Ser Pro Ala Leu Asn Asn Leu Gln Gln Thr Leu 
            500                 505                 510         


Asn Ile Val Thr Val Gln Lys Glu Val Ile Asp Thr Asn Leu Thr Thr 
        515                 520                 525             


Leu Arg Asp Gly Leu His Gly Ile Gln Arg Gly Asp Ile Asp Ala Met 
    530                 535                 540                 


Ile Ser Ser Ala Lys Ser Met Val Arg Lys Ala Asn Asp Ile Thr Asp 
545                 550                 555                 560 


Glu Val Leu Asp Gly Leu Asn Pro Ile Gln Thr Asp Val Glu Arg Ile 
                565                 570                 575     


Lys Asp Thr Tyr Gly Arg Thr Gln Asn Glu Asp Phe Lys Lys Ala Leu 
            580                 585                 590         


Thr Asp Ala Asp Asn Ser Val Asn Lys Leu Thr Asn Lys Leu Pro Asp 
        595                 600                 605             


Leu Trp Arg Lys Ile Glu Ser Ile Asn Gln Gln Leu Leu Pro Leu Gly 
    610                 615                 620                 


Asn Ile Ser Asp Asn Met Asp Arg Ile Arg Glu Leu Ile Gln Gln Ala 
625                 630                 635                 640 


Arg Asp Ala Ala Ser Lys Val Ala Val Pro Met Arg Phe Asn Gly Lys 
                645                 650                 655     


Ser Gly Val Glu Val Arg Leu Pro Asn Asp Leu Glu Asp Leu Lys Gly 
            660                 665                 670         


Tyr Thr Ser Leu Ser Leu Phe Leu Gln Arg Pro Asn Ser Arg Glu Asn 
        675                 680                 685             


Gly Gly Thr Glu Asn Met Phe Val Met Tyr Leu Gly Asn Lys Asp Ala 
    690                 695                 700                 


Ser Arg Asp Tyr Ile Gly Met Ala Val Val Asp Gly Gln Leu Thr Cys 
705                 710                 715                 720 


Val Tyr Asn Leu Gly Asp Arg Glu Ala Glu Leu Gln Val Asp Gln Ile 
                725                 730                 735     


Leu Thr Lys Ser Glu Thr Lys Glu Ala Val Met Asp Arg Val Lys Phe 
            740                 745                 750         


Gln Arg Ile Tyr Gln Phe Ala Arg Leu Asn Tyr Thr Lys Gly Ala Thr 
        755                 760                 765             


Ser Ser Lys Pro Glu Thr Pro Gly Val Tyr Asp Met Asp Gly Arg Asn 
    770                 775                 780                 


Ser Asn Thr Leu Leu Asn Leu Asp Pro Glu Asn Val Val Phe Tyr Val 
785                 790                 795                 800 


Gly Gly Tyr Pro Pro Asp Phe Lys Leu Pro Ser Arg Leu Ser Phe Pro 
                805                 810                 815     


Pro Tyr Lys Gly Cys Ile Glu Leu Asp Asp Leu Asn Glu Asn Val Leu 
            820                 825                 830         


Ser Leu Tyr Asn Phe Lys Lys Thr Phe Asn Leu Asn Thr Thr Glu Val 
        835                 840                 845             


Glu Pro Cys Arg Arg Arg Lys Glu Glu Ser Asp Lys Asn Tyr Phe Glu 
    850                 855                 860                 


Gly Thr Gly Tyr Ala Arg Val Pro Thr Gln Pro His Ala Pro Ile Pro 
865                 870                 875                 880 


Thr Phe Gly Gln Thr Ile Gln Thr Thr Val Asp Arg Gly Leu Leu Phe 
                885                 890                 895     


Phe Ala Glu Asn Gly Asp Arg Phe Ile Ser Leu Asn Ile Glu Asp Gly 
            900                 905                 910         


Lys Leu Met Val Arg Tyr Lys Leu Asn Ser Glu Leu Pro Lys Glu Arg 
        915                 920                 925             


Gly Val Gly Asp Ala Ile Asn Asn Gly Arg Asp His Ser Ile Gln Ile 
    930                 935                 940                 


Lys Ile Gly Lys Leu Gln Lys Arg Met Trp Ile Asn Val Asp Val Gln 
945                 950                 955                 960 


Asn Thr Ile Ile Asp Gly Glu Val Phe Asp Phe Ser Thr Tyr Tyr Leu 
                965                 970                 975     


Gly Gly Ile Pro Ile Ala Ile Arg Glu Arg Phe Asn Ile Ser Thr Pro 
            980                 985                 990         


Ala Phe Arg Gly Cys Met Lys Asn  Leu Lys Lys Thr Ser  Gly Val Val 
        995                 1000                 1005             


Arg Leu  Asn Asp Thr Val Gly  Val Thr Lys Lys Cys  Ser Glu Asp 
    1010                 1015                 1020             


Trp Lys  Leu Val Arg Ser Ala  Ser Phe Ser Arg Gly  Gly Gln Leu 
    1025                 1030                 1035             


Ser Phe  Thr Asp Leu Gly Leu  Pro Pro Thr Asp His  Leu Gln Ala 
    1040                 1045                 1050             


Ser Phe  Gly Phe Gln Thr Phe  Gln Pro Ser Gly Ile  Leu Leu Asp 
    1055                 1060                 1065             


His Gln  Thr Trp Thr Arg Asn  Leu Gln Val Thr Leu  Glu Asp Gly 
    1070                 1075                 1080             


Tyr Ile  Glu Leu Ser Thr Ser  Asp Ser Gly Gly Pro  Ile Phe Lys 
    1085                 1090                 1095             


Ser Pro  Gln Thr Tyr Met Asp  Gly Leu Leu His Tyr  Val Ser Val 
    1100                 1105                 1110             


Ile Ser  Asp Asn Ser Gly Leu  Arg Gln Glu Gly Cys  Leu Arg Pro 
    1115                 1120                 1125             


Arg Val  Arg Asp Gln Ser Trp  Lys His Ser Glu Thr  Met Ser Leu 
    1130                 1135                 1140             


Arg Lys  Leu Lys 
    1145         


<210>  7655
<211>  134
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7655

Xaa Phe Ser Glu Glu Gly Gly His Val Val Leu Ala His Ser Val Leu 
1               5                   10                  15      


Leu Gly Pro Glu Phe Lys Leu Val Phe Ser Ile Arg Pro Arg Ser Leu 
            20                  25                  30          


Thr Gly Ile Leu Ile His Ile Gly Ser Gln Pro Gly Lys His Leu Cys 
        35                  40                  45              


Val Tyr Leu Glu Ala Gly Lys Val Thr Ala Ser Met Asp Ser Gly Ala 
    50                  55                  60                  


Gly Gly Thr Ser Thr Ser Val Thr Pro Lys Gln Ser Leu Cys Asp Gly 
65                  70                  75                  80  


Gln Trp His Ser Val Ala Ala Asn Leu Thr Thr Leu Arg Ile Pro Val 
                85                  90                  95      


Trp Lys Ser Phe Phe Gly Cys Leu Arg Asn Ile His Val Asn His Ile 
            100                 105                 110         


Pro Val Pro Val Thr Glu Ala Leu Glu Val Gln Gly Pro Val Ser Leu 
        115                 120                 125             


Asn Gly Cys Pro Asp Gln 
    130                 


<210>  7656
<211>  37
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7656

Xaa Gly Trp Thr Glu Gly Pro Gly Gly Lys Phe Ala Trp Lys Leu His 
1               5                   10                  15      


His Gln His Gln Ser Ala Ser Leu Pro Gly Ile Thr Ser Ile Arg Glu 
            20                  25                  30          


Thr Lys Gly Ala Gly 
        35          


<210>  7657
<211>  81
<212>  PRT
<213>  Homo Sapiens

<400>  7657

Met Ala Leu Ser Ser Ala Trp Arg Ser Val Leu Pro Leu Trp Leu Leu 
1               5                   10                  15      


Trp Ser Ala Ala Cys Ser Arg Ala Ala Ser Gly Asp Asp Asn Ala Phe 
            20                  25                  30          


Pro Phe Asp Ile Glu Gly Ser Ser Ala Val Gly Arg Gln Asp Pro Pro 
        35                  40                  45              


Glu Thr Ser Glu Pro Arg Val Ala Leu Gly Arg Leu Pro Pro Ala Ala 
    50                  55                  60                  


Glu Lys Cys Asn Ala Gly Phe Phe His Thr Leu Ser Gly Glu Cys Val 
65                  70                  75                  80  


Pro 
    


<210>  7658
<211>  88
<212>  PRT
<213>  Homo Sapiens

<400>  7658

Met Ala Leu Ser Ser Ala Trp Arg Ser Val Leu Pro Leu Trp Leu Leu 
1               5                   10                  15      


Trp Ser Ala Ala Cys Ser Arg Ala Ala Ser Gly Asp Asp Asn Ala Phe 
            20                  25                  30          


Pro Phe Asp Ile Glu Gly Ser Ser Ala Val Gly Arg Gln Asp Pro Pro 
        35                  40                  45              


Glu Thr Ser Glu Pro Arg Val Ala Leu Gly Arg Leu Pro Pro Ala Ala 
    50                  55                  60                  


Glu Lys Cys Asn Ala Gly Phe Phe His Thr Leu Ser Gly Glu Cys Val 
65                  70                  75                  80  


Pro Cys Asp Cys Asn Gly Asn Ser 
                85              


<210>  7659
<211>  107
<212>  PRT
<213>  Homo Sapiens

<400>  7659

Met Ala Leu Ser Ser Ala Trp Arg Ser Val Leu Pro Leu Trp Leu Leu 
1               5                   10                  15      


Trp Ser Ala Ala Cys Ser Arg Ala Ala Ser Gly Asp Asp Asn Ala Phe 
            20                  25                  30          


Pro Phe Asp Ile Glu Gly Ser Ser Ala Val Gly Arg Gln Asp Pro Pro 
        35                  40                  45              


Glu Thr Ser Glu Pro Arg Val Ala Leu Gly Arg Leu Pro Pro Ala Ala 
    50                  55                  60                  


Glu Lys Cys Asn Ala Gly Phe Phe His Thr Leu Ser Gly Glu Cys Val 
65                  70                  75                  80  


Pro Cys Asp Cys Asn Gly Asn Ser Asn Glu Cys Leu Asp Gly Ser Gly 
                85                  90                  95      


Tyr Cys Val His Cys Gln Arg Asn Thr Thr Gly 
            100                 105         


<210>  7660
<211>  1823
<212>  PRT
<213>  Homo Sapiens

<400>  7660

Met Ala Leu Ser Ser Ala Trp Arg Ser Val Leu Pro Leu Trp Leu Leu 
1               5                   10                  15      


Trp Ser Ala Ala Cys Ser Arg Ala Ala Ser Gly Asp Asp Asn Ala Phe 
            20                  25                  30          


Pro Phe Asp Ile Glu Gly Ser Ser Ala Val Gly Arg Gln Asp Pro Pro 
        35                  40                  45              


Glu Thr Ser Glu Pro Arg Val Ala Leu Gly Arg Leu Pro Pro Ala Ala 
    50                  55                  60                  


Glu Lys Cys Asn Ala Gly Phe Phe His Thr Leu Ser Gly Glu Cys Val 
65                  70                  75                  80  


Pro Cys Asp Cys Asn Gly Asn Ser Asn Glu Cys Leu Asp Gly Ser Gly 
                85                  90                  95      


Tyr Cys Val His Cys Gln Arg Asn Thr Thr Gly Glu His Cys Glu Lys 
            100                 105                 110         


Cys Leu Asp Gly Tyr Ile Gly Asp Ser Ile Arg Gly Ala Pro Gln Phe 
        115                 120                 125             


Cys Gln Pro Cys Pro Cys Pro Leu Pro His Leu Ala Asn Phe Ala Glu 
    130                 135                 140                 


Ser Cys Tyr Arg Lys Asn Gly Ala Val Arg Cys Ile Cys Asn Glu Asn 
145                 150                 155                 160 


Tyr Ala Gly Pro Asn Cys Glu Arg Cys Ala Pro Gly Tyr Tyr Gly Asn 
                165                 170                 175     


Pro Leu Leu Ile Gly Ser Thr Cys Lys Lys Cys Asp Cys Ser Gly Asn 
            180                 185                 190         


Ser Asp Pro Asn Leu Ile Phe Glu Asp Cys Asp Glu Val Thr Gly Gln 
        195                 200                 205             


Cys Arg Asn Cys Leu Arg Asn Thr Thr Gly Phe Lys Cys Glu Arg Cys 
    210                 215                 220                 


Ala Pro Gly Tyr Tyr Gly Asp Ala Arg Ile Ala Lys Asn Cys Ala Val 
225                 230                 235                 240 


Cys Asn Cys Gly Gly Gly Pro Cys Asp Ser Val Thr Gly Glu Cys Leu 
                245                 250                 255     


Glu Glu Gly Phe Glu Pro Pro Thr Gly Met Asp Cys Pro Thr Ile Ser 
            260                 265                 270         


Cys Asp Lys Cys Val Trp Asp Leu Thr Asp Asp Leu Arg Leu Ala Ala 
        275                 280                 285             


Leu Ser Ile Glu Glu Gly Lys Ser Gly Val Leu Ser Val Ser Ser Gly 
    290                 295                 300                 


Ala Ala Ala His Arg His Val Asn Glu Ile Asn Ala Thr Ile Tyr Leu 
305                 310                 315                 320 


Leu Lys Thr Lys Leu Ser Glu Arg Glu Asn Gln Tyr Ala Leu Arg Lys 
                325                 330                 335     


Ile Gln Ile Asn Asn Ala Glu Asn Thr Met Lys Ser Leu Leu Ser Asp 
            340                 345                 350         


Val Glu Glu Leu Val Glu Lys Glu Asn Gln Ala Ser Arg Lys Gly Gln 
        355                 360                 365             


Leu Val Gln Lys Glu Ser Met Asp Thr Ile Asn His Ala Ser Gln Leu 
    370                 375                 380                 


Val Glu Gln Ala His Asp Met Arg Asp Lys Ile Gln Glu Ile Asn Asn 
385                 390                 395                 400 


Lys Met Leu Tyr Tyr Gly Glu Glu His Glu Leu Ser Pro Lys Glu Ile 
                405                 410                 415     


Ser Glu Lys Leu Val Leu Ala Gln Lys Met Leu Glu Glu Ile Arg Ser 
            420                 425                 430         


Arg Gln Pro Phe Phe Thr Gln Arg Glu Leu Val Asp Glu Glu Ala Asp 
        435                 440                 445             


Glu Ala Tyr Glu Leu Leu Ser Gln Ala Glu Ser Trp Gln Arg Leu His 
    450                 455                 460                 


Asn Glu Thr Arg Thr Leu Phe Pro Val Val Leu Glu Gln Leu Asp Asp 
465                 470                 475                 480 


Tyr Asn Ala Lys Leu Ser Asp Leu Gln Glu Ala Leu Asp Gln Ala Leu 
                485                 490                 495     


Asn Tyr Val Arg Asp Ala Glu Asp Met Asn Arg Ala Thr Ala Ala Arg 
            500                 505                 510         


Gln Arg Asp His Glu Lys Gln Gln Glu Arg Val Arg Glu Gln Met Glu 
        515                 520                 525             


Val Val Asn Met Ser Leu Ser Thr Ser Ala Asp Ser Leu Thr Thr Pro 
    530                 535                 540                 


Arg Leu Thr Leu Ser Glu Leu Asp Asp Ile Ile Lys Asn Ala Ser Gly 
545                 550                 555                 560 


Ile Tyr Ala Glu Ile Asp Gly Ala Lys Ser Glu Leu Gln Val Lys Leu 
                565                 570                 575     


Ser Asn Leu Ser Asn Leu Ser His Asp Leu Val Gln Glu Ala Ile Asp 
            580                 585                 590         


His Ala Gln Asp Leu Gln Gln Glu Ala Asn Glu Leu Ser Arg Lys Leu 
        595                 600                 605             


His Ser Ser Asp Met Asn Gly Leu Val Gln Lys Ala Leu Asp Ala Ser 
    610                 615                 620                 


Asn Val Tyr Glu Asn Ile Val Asn Tyr Val Ser Glu Ala Asn Glu Thr 
625                 630                 635                 640 


Ala Glu Phe Ala Leu Asn Thr Thr Asp Arg Ile Tyr Asp Ala Val Ser 
                645                 650                 655     


Gly Ile Asp Thr Gln Ile Ile Tyr His Lys Asp Glu Ser Glu Asn Leu 
            660                 665                 670         


Leu Asn Gln Ala Arg Glu Leu Gln Ala Lys Ala Glu Ser Ser Ser Asp 
        675                 680                 685             


Glu Ala Val Ala Asp Thr Ser Arg Arg Val Gly Gly Ala Leu Ala Arg 
    690                 695                 700                 


Lys Ser Ala Leu Lys Thr Arg Leu Ser Asp Ala Val Lys Gln Leu Gln 
705                 710                 715                 720 


Ala Ala Glu Arg Gly Asp Ala Gln Gln Arg Leu Gly Gln Ser Arg Leu 
                725                 730                 735     


Ile Thr Glu Glu Ala Asn Arg Thr Thr Met Glu Val Gln Gln Ala Thr 
            740                 745                 750         


Ala Pro Met Ala Asn Asn Leu Thr Asn Trp Ser Gln Asn Leu Gln His 
        755                 760                 765             


Phe Asp Ser Ser Ala Tyr Asn Thr Ala Val Asn Ser Ala Arg Asp Ala 
    770                 775                 780                 


Val Arg Asn Leu Thr Glu Val Val Pro Gln Leu Leu Asp Gln Leu Arg 
785                 790                 795                 800 


Thr Val Glu Gln Lys Arg Pro Ala Ser Asn Val Ser Ala Ser Ile Gln 
                805                 810                 815     


Arg Ile Arg Glu Leu Ile Ala Gln Thr Arg Ser Val Ala Ser Lys Ile 
            820                 825                 830         


Gln Val Ser Met Met Phe Asp Gly Gln Ser Ala Val Glu Val His Ser 
        835                 840                 845             


Arg Thr Ser Met Asp Asp Leu Lys Ala Phe Thr Ser Leu Ser Leu Tyr 
    850                 855                 860                 


Met Lys Pro Pro Val Lys Arg Pro Glu Leu Thr Glu Thr Ala Asp Gln 
865                 870                 875                 880 


Phe Ile Leu Tyr Leu Gly Ser Lys Asn Ala Lys Lys Glu Tyr Met Gly 
                885                 890                 895     


Leu Ala Ile Lys Asn Asp Asn Leu Val Tyr Val Tyr Asn Leu Gly Thr 
            900                 905                 910         


Lys Asp Val Glu Ile Pro Leu Asp Ser Lys Pro Val Ser Ser Trp Pro 
        915                 920                 925             


Ala Tyr Phe Ser Ile Val Lys Ile Glu Arg Val Gly Lys His Gly Lys 
    930                 935                 940                 


Val Phe Leu Thr Val Pro Ser Leu Ser Ser Thr Ala Glu Glu Lys Phe 
945                 950                 955                 960 


Ile Lys Lys Gly Glu Phe Ser Gly Asp Asp Ser Leu Leu Asp Leu Asp 
                965                 970                 975     


Pro Glu Asp Thr Val Phe Tyr Val Gly Gly Val Pro Ser Asn Phe Lys 
            980                 985                 990         


Leu Pro Thr Ser Leu Asn Leu Pro  Gly Phe Val Gly Cys  Leu Glu Leu 
        995                 1000                 1005             


Ala Thr  Leu Asn Asn Asp Val  Ile Ser Leu Tyr Asn  Phe Lys His 
    1010                 1015                 1020             


Ile Tyr  Asn Met Asp Pro Ser  Thr Ser Val Pro Cys  Ala Arg Asp 
    1025                 1030                 1035             


Lys Leu  Ala Phe Thr Gln Ser  Arg Ala Ala Ser Tyr  Phe Phe Asp 
    1040                 1045                 1050             


Gly Ser  Gly Tyr Ala Val Val  Arg Asp Ile Thr Arg  Arg Gly Lys 
    1055                 1060                 1065             


Phe Gly  Gln Val Thr Arg Phe  Asp Ile Glu Val Arg  Thr Pro Ala 
    1070                 1075                 1080             


Asp Asn  Gly Leu Ile Leu Leu  Met Val Asn Gly Ser  Met Phe Phe 
    1085                 1090                 1095             


Arg Leu  Glu Met Arg Asn Gly  Tyr Leu His Val Phe  Tyr Asp Phe 
    1100                 1105                 1110             


Gly Phe  Ser Gly Gly Pro Val  His Leu Glu Asp Thr  Leu Lys Lys 
    1115                 1120                 1125             


Ala Gln  Ile Asn Asp Ala Lys  Tyr His Glu Ile Ser  Ile Ile Tyr 
    1130                 1135                 1140             


His Asn  Asp Lys Lys Met Ile  Leu Val Val Asp Arg  Arg His Val 
    1145                 1150                 1155             


Lys Ser  Met Asp Asn Glu Lys  Met Lys Ile Pro Phe  Thr Asp Ile 
    1160                 1165                 1170             


Tyr Ile  Gly Gly Ala Pro Pro  Glu Ile Leu Gln Ser  Arg Ala Leu 
    1175                 1180                 1185             


Arg Ala  His Leu Pro Leu Asp  Ile Asn Phe Arg Gly  Cys Met Lys 
    1190                 1195                 1200             


Gly Phe  Gln Phe Gln Lys Lys  Asp Phe Asn Leu Leu  Glu Gln Thr 
    1205                 1210                 1215             


Glu Thr  Leu Gly Val Gly Tyr  Gly Cys Pro Glu Asp  Ser Leu Ile 
    1220                 1225                 1230             


Ser Arg  Arg Ala Tyr Phe Asn  Gly Gln Ser Phe Ile  Ala Ser Ile 
    1235                 1240                 1245             


Gln Lys  Ile Ser Phe Phe Asp  Gly Phe Glu Gly Gly  Phe Asn Phe 
    1250                 1255                 1260             


Arg Thr  Leu Gln Pro Asn Gly  Leu Leu Phe Tyr Tyr  Ala Ser Gly 
    1265                 1270                 1275             


Ser Asp  Val Phe Ser Ile Ser  Leu Asp Asn Gly Thr  Val Ile Met 
    1280                 1285                 1290             


Asp Val  Lys Gly Ile Lys Val  Gln Ser Val Asp Lys  Gln Tyr Asn 
    1295                 1300                 1305             


Asp Gly  Leu Ser His Phe Val  Ile Ser Ser Val Ser  Pro Thr Arg 
    1310                 1315                 1320             


Tyr Glu  Leu Ile Val Asp Lys  Ser Arg Val Gly Ser  Lys Asn Pro 
    1325                 1330                 1335             


Thr Lys  Gly Lys Ile Glu Gln  Thr Gln Ala Ser Glu  Lys Lys Phe 
    1340                 1345                 1350             


Tyr Phe  Gly Gly Ser Pro Ile  Ser Ala Gln Tyr Ala  Asn Phe Thr 
    1355                 1360                 1365             


Gly Cys  Ile Ser Asn Ala Tyr  Phe Thr Arg Val Asp  Arg Asp Val 
    1370                 1375                 1380             


Glu Val  Glu Asp Phe Gln Arg  Tyr Thr Glu Lys Val  His Thr Ser 
    1385                 1390                 1395             


Leu Tyr  Glu Cys Pro Ile Glu  Ser Ser Pro Leu Phe  Leu Leu His 
    1400                 1405                 1410             


Lys Lys  Gly Lys Asn Leu Ser  Lys Pro Lys Ala Ser  Gln Asn Lys 
    1415                 1420                 1425             


Lys Gly  Gly Lys Ser Lys Asp  Ala Pro Ser Trp Asp  Pro Val Ala 
    1430                 1435                 1440             


Leu Lys  Leu Pro Glu Arg Asn  Thr Pro Arg Asn Ser  His Cys His 
    1445                 1450                 1455             


Leu Ser  Asn Ser Pro Arg Ala  Ile Glu His Ala Tyr  Gln Tyr Gly 
    1460                 1465                 1470             


Gly Thr  Ala Asn Ser Arg Gln  Glu Phe Glu His Leu  Lys Gly Asp 
    1475                 1480                 1485             


Phe Gly  Ala Lys Ser Gln Phe  Ser Ile Arg Leu Arg  Thr Arg Ser 
    1490                 1495                 1500             


Ser His  Gly Met Ile Phe Tyr  Val Ser Asp Gln Glu  Glu Asn Asp 
    1505                 1510                 1515             


Phe Met  Thr Leu Phe Leu Ala  His Gly Arg Leu Val  Tyr Met Phe 
    1520                 1525                 1530             


Asn Val  Gly His Lys Lys Leu  Lys Ile Arg Ser Gln  Glu Lys Tyr 
    1535                 1540                 1545             


Asn Asp  Gly Leu Trp His Asp  Val Ile Phe Ile Arg  Glu Arg Ser 
    1550                 1555                 1560             


Ser Gly  Arg Leu Val Ile Asp  Gly Leu Arg Val Leu  Glu Glu Ser 
    1565                 1570                 1575             


Leu Pro  Pro Thr Glu Ala Thr  Trp Lys Ile Lys Gly  Pro Ile Tyr 
    1580                 1585                 1590             


Leu Gly  Gly Val Ala Pro Gly  Lys Ala Val Lys Asn  Val Gln Ile 
    1595                 1600                 1605             


Asn Ser  Ile Tyr Ser Phe Ser  Gly Cys Leu Ser Asn  Leu Gln Leu 
    1610                 1615                 1620             


Asn Gly  Ala Ser Ile Thr Ser  Ala Ser Gln Thr Phe  Ser Val Thr 
    1625                 1630                 1635             


Pro Cys  Phe Glu Gly Pro Met  Glu Thr Gly Thr Tyr  Phe Ser Thr 
    1640                 1645                 1650             


Glu Gly  Gly Tyr Val Val Leu  Asp Glu Ser Phe Asn  Ile Gly Leu 
    1655                 1660                 1665             


Lys Phe  Glu Ile Ala Phe Glu  Val Arg Pro Arg Ser  Ser Ser Gly 
    1670                 1675                 1680             


Thr Leu  Val His Gly His Ser  Val Asn Gly Glu Tyr  Leu Asn Val 
    1685                 1690                 1695             


His Met  Lys Asn Gly Gln Val  Ile Val Lys Val Asn  Asn Gly Ile 
    1700                 1705                 1710             


Arg Asp  Phe Ser Thr Ser Val  Thr Pro Lys Gln Ser  Leu Cys Asp 
    1715                 1720                 1725             


Gly Arg  Trp His Arg Ile Thr  Val Ile Arg Asp Ser  Asn Val Val 
    1730                 1735                 1740             


Gln Leu  Asp Val Asp Ser Glu  Val Asn His Val Val  Gly Pro Leu 
    1745                 1750                 1755             


Asn Pro  Lys Pro Ile Asp His  Arg Glu Pro Val Phe  Val Gly Gly 
    1760                 1765                 1770             


Val Pro  Glu Ser Leu Leu Thr  Pro Arg Leu Ala Pro  Ser Lys Pro 
    1775                 1780                 1785             


Phe Thr  Gly Cys Ile Arg His  Phe Val Ile Asp Gly  His Pro Val 
    1790                 1795                 1800             


Ser Phe  Ser Lys Ala Ala Leu  Val Ser Gly Ala Val  Ser Ile Asn 
    1805                 1810                 1815             


Ser Cys  Pro Ala Ala 
    1820             


<210>  7661
<211>  1816
<212>  PRT
<213>  Homo Sapiens

<400>  7661

Met Ala Leu Ser Ser Ala Trp Arg Ser Val Leu Pro Leu Trp Leu Leu 
1               5                   10                  15      


Trp Ser Ala Ala Cys Ser Arg Ala Ala Ser Gly Asp Asp Asn Ala Phe 
            20                  25                  30          


Pro Phe Asp Ile Glu Gly Ser Ser Ala Val Gly Arg Gln Asp Pro Pro 
        35                  40                  45              


Glu Thr Ser Glu Pro Arg Val Ala Leu Gly Arg Leu Pro Pro Ala Ala 
    50                  55                  60                  


Glu Lys Cys Asn Ala Gly Phe Phe His Thr Leu Ser Gly Glu Cys Val 
65                  70                  75                  80  


Pro Cys Asp Cys Asn Gly Asn Ser Asn Glu Cys Leu Asp Gly Ser Gly 
                85                  90                  95      


Tyr Cys Val His Cys Gln Arg Asn Thr Thr Gly Glu His Cys Glu Lys 
            100                 105                 110         


Cys Leu Asp Gly Tyr Ile Gly Asp Ser Ile Arg Gly Ala Pro Gln Phe 
        115                 120                 125             


Cys Gln Pro Cys Pro Cys Pro Leu Pro His Leu Ala Asn Phe Ala Glu 
    130                 135                 140                 


Ser Cys Tyr Arg Lys Asn Gly Ala Val Arg Cys Ile Cys Asn Glu Asn 
145                 150                 155                 160 


Tyr Ala Gly Pro Asn Cys Glu Arg Cys Ala Pro Gly Tyr Tyr Gly Asn 
                165                 170                 175     


Pro Leu Leu Ile Gly Ser Thr Cys Lys Lys Cys Asp Cys Ser Gly Asn 
            180                 185                 190         


Ser Asp Pro Asn Leu Ile Phe Glu Asp Cys Asp Glu Val Thr Gly Gln 
        195                 200                 205             


Cys Arg Asn Cys Leu Arg Asn Thr Thr Gly Phe Lys Cys Glu Arg Cys 
    210                 215                 220                 


Ala Pro Gly Tyr Tyr Gly Asp Ala Arg Ile Ala Lys Asn Cys Ala Val 
225                 230                 235                 240 


Cys Asn Cys Gly Gly Gly Pro Cys Asp Ser Val Thr Gly Glu Cys Leu 
                245                 250                 255     


Glu Glu Gly Phe Glu Pro Pro Thr Gly Cys Asp Lys Cys Val Trp Asp 
            260                 265                 270         


Leu Thr Asp Asp Leu Arg Leu Ala Ala Leu Ser Ile Glu Glu Gly Lys 
        275                 280                 285             


Ser Gly Val Leu Ser Val Ser Ser Gly Ala Ala Ala His Arg His Val 
    290                 295                 300                 


Asn Glu Ile Asn Ala Thr Ile Tyr Leu Leu Lys Thr Lys Leu Ser Glu 
305                 310                 315                 320 


Arg Glu Asn Gln Tyr Ala Leu Arg Lys Ile Gln Ile Asn Asn Ala Glu 
                325                 330                 335     


Asn Thr Met Lys Ser Leu Leu Ser Asp Val Glu Glu Leu Val Glu Lys 
            340                 345                 350         


Glu Asn Gln Ala Ser Arg Lys Gly Gln Leu Val Gln Lys Glu Ser Met 
        355                 360                 365             


Asp Thr Ile Asn His Ala Ser Gln Leu Val Glu Gln Ala His Asp Met 
    370                 375                 380                 


Arg Asp Lys Ile Gln Glu Ile Asn Asn Lys Met Leu Tyr Tyr Gly Glu 
385                 390                 395                 400 


Glu His Glu Leu Ser Pro Lys Glu Ile Ser Glu Lys Leu Val Leu Ala 
                405                 410                 415     


Gln Lys Met Leu Glu Glu Ile Arg Ser Arg Gln Pro Phe Phe Thr Gln 
            420                 425                 430         


Arg Glu Leu Val Asp Glu Glu Ala Asp Glu Ala Tyr Glu Leu Leu Ser 
        435                 440                 445             


Gln Ala Glu Ser Trp Gln Arg Leu His Asn Glu Thr Arg Thr Leu Phe 
    450                 455                 460                 


Pro Val Val Leu Glu Gln Leu Asp Asp Tyr Asn Ala Lys Leu Ser Asp 
465                 470                 475                 480 


Leu Gln Glu Ala Leu Asp Gln Ala Leu Asn Tyr Val Arg Asp Ala Glu 
                485                 490                 495     


Asp Met Asn Arg Ala Thr Ala Ala Arg Gln Arg Asp His Glu Lys Gln 
            500                 505                 510         


Gln Glu Arg Val Arg Glu Gln Met Glu Val Val Asn Met Ser Leu Ser 
        515                 520                 525             


Thr Ser Ala Asp Ser Leu Thr Thr Pro Arg Leu Thr Leu Ser Glu Leu 
    530                 535                 540                 


Asp Asp Ile Ile Lys Asn Ala Ser Gly Ile Tyr Ala Glu Ile Asp Gly 
545                 550                 555                 560 


Ala Lys Ser Glu Leu Gln Val Lys Leu Ser Asn Leu Ser Asn Leu Ser 
                565                 570                 575     


His Asp Leu Val Gln Glu Ala Ile Asp His Ala Gln Asp Leu Gln Gln 
            580                 585                 590         


Glu Ala Asn Glu Leu Ser Arg Lys Leu His Ser Ser Asp Met Asn Gly 
        595                 600                 605             


Leu Val Gln Lys Ala Leu Asp Ala Ser Asn Val Tyr Glu Asn Ile Val 
    610                 615                 620                 


Asn Tyr Val Ser Glu Ala Asn Glu Thr Ala Glu Phe Ala Leu Asn Thr 
625                 630                 635                 640 


Thr Asp Arg Ile Tyr Asp Ala Val Ser Gly Ile Asp Thr Gln Ile Ile 
                645                 650                 655     


Tyr His Lys Asp Glu Ser Glu Asn Leu Leu Asn Gln Ala Arg Glu Leu 
            660                 665                 670         


Gln Ala Lys Ala Glu Ser Ser Ser Asp Glu Ala Val Ala Asp Thr Ser 
        675                 680                 685             


Arg Arg Val Gly Gly Ala Leu Ala Arg Lys Ser Ala Leu Lys Thr Arg 
    690                 695                 700                 


Leu Ser Asp Ala Val Lys Gln Leu Gln Ala Ala Glu Arg Gly Asp Ala 
705                 710                 715                 720 


Gln Gln Arg Leu Gly Gln Ser Arg Leu Ile Thr Glu Glu Ala Asn Arg 
                725                 730                 735     


Thr Thr Met Glu Val Gln Gln Ala Thr Ala Pro Met Ala Asn Asn Leu 
            740                 745                 750         


Thr Asn Trp Ser Gln Asn Leu Gln His Phe Asp Ser Ser Ala Tyr Asn 
        755                 760                 765             


Thr Ala Val Asn Ser Ala Arg Asp Ala Val Arg Asn Leu Thr Glu Val 
    770                 775                 780                 


Val Pro Gln Leu Leu Asp Gln Leu Arg Thr Val Glu Gln Lys Arg Pro 
785                 790                 795                 800 


Ala Ser Asn Val Ser Ala Ser Ile Gln Arg Ile Arg Glu Leu Ile Ala 
                805                 810                 815     


Gln Thr Arg Ser Val Ala Ser Lys Ile Gln Val Ser Met Met Phe Asp 
            820                 825                 830         


Gly Gln Ser Ala Val Glu Val His Ser Arg Thr Ser Met Asp Asp Leu 
        835                 840                 845             


Lys Ala Phe Thr Ser Leu Ser Leu Tyr Met Lys Pro Pro Val Lys Arg 
    850                 855                 860                 


Pro Glu Leu Thr Glu Thr Ala Asp Gln Phe Ile Leu Tyr Leu Gly Ser 
865                 870                 875                 880 


Lys Asn Ala Lys Lys Glu Tyr Met Gly Leu Ala Ile Lys Asn Asp Asn 
                885                 890                 895     


Leu Val Tyr Val Tyr Asn Leu Gly Thr Lys Asp Val Glu Ile Pro Leu 
            900                 905                 910         


Asp Ser Lys Pro Val Ser Ser Trp Pro Ala Tyr Phe Ser Ile Val Lys 
        915                 920                 925             


Ile Glu Arg Val Gly Lys His Gly Lys Val Phe Leu Thr Val Pro Ser 
    930                 935                 940                 


Leu Ser Ser Thr Ala Glu Glu Lys Phe Ile Lys Lys Gly Glu Phe Ser 
945                 950                 955                 960 


Gly Asp Asp Ser Leu Leu Asp Leu Asp Pro Glu Asp Thr Val Phe Tyr 
                965                 970                 975     


Val Gly Gly Val Pro Ser Asn Phe Lys Leu Pro Thr Ser Leu Asn Leu 
            980                 985                 990         


Pro Gly Phe Val Gly Cys Leu Glu  Leu Ala Thr Leu Asn  Asn Asp Val 
        995                 1000                 1005             


Ile Ser  Leu Tyr Asn Phe Lys  His Ile Tyr Asn Met  Asp Pro Ser 
    1010                 1015                 1020             


Thr Ser  Val Pro Cys Ala Arg  Asp Lys Leu Ala Phe  Thr Gln Ser 
    1025                 1030                 1035             


Arg Ala  Ala Ser Tyr Phe Phe  Asp Gly Ser Gly Tyr  Ala Val Val 
    1040                 1045                 1050             


Arg Asp  Ile Thr Arg Arg Gly  Lys Phe Gly Gln Val  Thr Arg Phe 
    1055                 1060                 1065             


Asp Ile  Glu Val Arg Thr Pro  Ala Asp Asn Gly Leu  Ile Leu Leu 
    1070                 1075                 1080             


Met Val  Asn Gly Ser Met Phe  Phe Arg Leu Glu Met  Arg Asn Gly 
    1085                 1090                 1095             


Tyr Leu  His Val Phe Tyr Asp  Phe Gly Phe Ser Gly  Gly Pro Val 
    1100                 1105                 1110             


His Leu  Glu Asp Thr Leu Lys  Lys Ala Gln Ile Asn  Asp Ala Lys 
    1115                 1120                 1125             


Tyr His  Glu Ile Ser Ile Ile  Tyr His Asn Asp Lys  Lys Met Ile 
    1130                 1135                 1140             


Leu Val  Val Asp Arg Arg His  Val Lys Ser Met Asp  Asn Glu Lys 
    1145                 1150                 1155             


Met Lys  Ile Pro Phe Thr Asp  Ile Tyr Ile Gly Gly  Ala Pro Pro 
    1160                 1165                 1170             


Glu Ile  Leu Gln Ser Arg Ala  Leu Arg Ala His Leu  Pro Leu Asp 
    1175                 1180                 1185             


Ile Asn  Phe Arg Gly Cys Met  Lys Gly Phe Gln Phe  Gln Lys Lys 
    1190                 1195                 1200             


Asp Phe  Asn Leu Leu Glu Gln  Thr Glu Thr Leu Gly  Val Gly Tyr 
    1205                 1210                 1215             


Gly Cys  Pro Glu Asp Ser Leu  Ile Ser Arg Arg Ala  Tyr Phe Asn 
    1220                 1225                 1230             


Gly Gln  Ser Phe Ile Ala Ser  Ile Gln Lys Ile Ser  Phe Phe Asp 
    1235                 1240                 1245             


Gly Phe  Glu Gly Gly Phe Asn  Phe Arg Thr Leu Gln  Pro Asn Gly 
    1250                 1255                 1260             


Leu Leu  Phe Tyr Tyr Ala Ser  Gly Ser Asp Val Phe  Ser Ile Ser 
    1265                 1270                 1275             


Leu Asp  Asn Gly Thr Val Ile  Met Asp Val Lys Gly  Ile Lys Val 
    1280                 1285                 1290             


Gln Ser  Val Asp Lys Gln Tyr  Asn Asp Gly Leu Ser  His Phe Val 
    1295                 1300                 1305             


Ile Ser  Ser Val Ser Pro Thr  Arg Tyr Glu Leu Ile  Val Asp Lys 
    1310                 1315                 1320             


Ser Arg  Val Gly Ser Lys Asn  Pro Thr Lys Gly Lys  Ile Glu Gln 
    1325                 1330                 1335             


Thr Gln  Ala Ser Glu Lys Lys  Phe Tyr Phe Gly Gly  Ser Pro Ile 
    1340                 1345                 1350             


Ser Ala  Gln Tyr Ala Asn Phe  Thr Gly Cys Ile Ser  Asn Ala Tyr 
    1355                 1360                 1365             


Phe Thr  Arg Val Asp Arg Asp  Val Glu Val Glu Asp  Phe Gln Arg 
    1370                 1375                 1380             


Tyr Thr  Glu Lys Val His Thr  Ser Leu Tyr Glu Cys  Pro Ile Glu 
    1385                 1390                 1395             


Ser Ser  Pro Leu Phe Leu Leu  His Lys Lys Gly Lys  Asn Leu Ser 
    1400                 1405                 1410             


Lys Pro  Lys Ala Ser Gln Asn  Lys Lys Gly Gly Lys  Ser Lys Asp 
    1415                 1420                 1425             


Ala Pro  Ser Trp Asp Pro Val  Ala Leu Lys Leu Pro  Glu Arg Asn 
    1430                 1435                 1440             


Thr Pro  Arg Asn Ser His Cys  His Leu Ser Asn Ser  Pro Arg Ala 
    1445                 1450                 1455             


Ile Glu  His Ala Tyr Gln Tyr  Gly Gly Thr Ala Asn  Ser Arg Gln 
    1460                 1465                 1470             


Glu Phe  Glu His Leu Lys Gly  Asp Phe Gly Ala Lys  Ser Gln Phe 
    1475                 1480                 1485             


Ser Ile  Arg Leu Arg Thr Arg  Ser Ser His Gly Met  Ile Phe Tyr 
    1490                 1495                 1500             


Val Ser  Asp Gln Glu Glu Asn  Asp Phe Met Thr Leu  Phe Leu Ala 
    1505                 1510                 1515             


His Gly  Arg Leu Val Tyr Met  Phe Asn Val Gly His  Lys Lys Leu 
    1520                 1525                 1530             


Lys Ile  Arg Ser Gln Glu Lys  Tyr Asn Asp Gly Leu  Trp His Asp 
    1535                 1540                 1545             


Val Ile  Phe Ile Arg Glu Arg  Ser Ser Gly Arg Leu  Val Ile Asp 
    1550                 1555                 1560             


Gly Leu  Arg Val Leu Glu Glu  Ser Leu Pro Pro Thr  Glu Ala Thr 
    1565                 1570                 1575             


Trp Lys  Ile Lys Gly Pro Ile  Tyr Leu Gly Gly Val  Ala Pro Gly 
    1580                 1585                 1590             


Lys Ala  Val Lys Asn Val Gln  Ile Asn Ser Ile Tyr  Ser Phe Ser 
    1595                 1600                 1605             


Gly Cys  Leu Ser Asn Leu Gln  Leu Asn Gly Ala Ser  Ile Thr Ser 
    1610                 1615                 1620             


Ala Ser  Gln Thr Phe Ser Val  Thr Pro Cys Phe Glu  Gly Pro Met 
    1625                 1630                 1635             


Glu Thr  Gly Thr Tyr Phe Ser  Thr Glu Gly Gly Tyr  Val Val Leu 
    1640                 1645                 1650             


Asp Glu  Ser Phe Asn Ile Gly  Leu Lys Phe Glu Ile  Ala Phe Glu 
    1655                 1660                 1665             


Val Arg  Pro Arg Ser Ser Ser  Gly Thr Leu Val His  Gly His Ser 
    1670                 1675                 1680             


Val Asn  Gly Glu Tyr Leu Asn  Val His Met Lys Asn  Gly Gln Val 
    1685                 1690                 1695             


Ile Val  Lys Val Asn Asn Gly  Ile Arg Asp Phe Ser  Thr Ser Val 
    1700                 1705                 1710             


Thr Pro  Lys Gln Ser Leu Cys  Asp Gly Arg Trp His  Arg Ile Thr 
    1715                 1720                 1725             


Val Ile  Arg Asp Ser Asn Val  Val Gln Leu Asp Val  Asp Ser Glu 
    1730                 1735                 1740             


Val Asn  His Val Val Gly Pro  Leu Asn Pro Lys Pro  Ile Asp His 
    1745                 1750                 1755             


Arg Glu  Pro Val Phe Val Gly  Gly Val Pro Glu Ser  Leu Leu Thr 
    1760                 1765                 1770             


Pro Arg  Leu Ala Pro Ser Lys  Pro Phe Thr Gly Cys  Ile Arg His 
    1775                 1780                 1785             


Phe Val  Ile Asp Gly His Pro  Val Ser Phe Ser Lys  Ala Ala Leu 
    1790                 1795                 1800             


Val Ser  Gly Ala Val Ser Ile  Asn Ser Cys Pro Ala  Ala 
    1805                 1810                 1815     


<210>  7662
<211>  1816
<212>  PRT
<213>  Homo Sapiens

<400>  7662

Met Ala Leu Ser Ser Ala Trp Arg Ser Val Leu Pro Leu Trp Leu Leu 
1               5                   10                  15      


Trp Ser Ala Ala Cys Ser Arg Ala Ala Ser Gly Asp Asp Asn Ala Phe 
            20                  25                  30          


Pro Phe Asp Ile Glu Gly Ser Ser Ala Val Gly Arg Gln Asp Pro Pro 
        35                  40                  45              


Glu Thr Ser Glu Pro Arg Val Ala Leu Gly Arg Leu Pro Pro Ala Ala 
    50                  55                  60                  


Glu Lys Cys Asn Ala Gly Phe Phe His Thr Leu Ser Gly Glu Cys Val 
65                  70                  75                  80  


Pro Cys Asp Cys Asn Gly Asn Ser Asn Glu Cys Leu Asp Gly Ser Gly 
                85                  90                  95      


Tyr Cys Val His Cys Gln Arg Asn Thr Thr Gly Glu His Cys Glu Lys 
            100                 105                 110         


Cys Leu Asp Gly Tyr Ile Gly Asp Ser Ile Arg Gly Ala Pro Gln Phe 
        115                 120                 125             


Cys Gln Pro Cys Pro Cys Pro Leu Pro His Leu Ala Asn Phe Ala Glu 
    130                 135                 140                 


Ser Cys Tyr Arg Lys Asn Gly Ala Val Arg Cys Ile Cys Asn Glu Asn 
145                 150                 155                 160 


Tyr Ala Gly Pro Asn Cys Glu Arg Cys Ala Pro Gly Tyr Tyr Gly Asn 
                165                 170                 175     


Pro Leu Leu Ile Gly Ser Thr Cys Lys Lys Cys Asp Cys Ser Gly Asn 
            180                 185                 190         


Ser Asp Pro Asn Leu Ile Phe Glu Asp Cys Asp Glu Val Thr Gly Gln 
        195                 200                 205             


Cys Arg Asn Cys Leu Arg Asn Thr Thr Gly Phe Lys Cys Glu Arg Cys 
    210                 215                 220                 


Ala Pro Gly Tyr Tyr Gly Asp Ala Arg Ile Ala Lys Asn Cys Ala Val 
225                 230                 235                 240 


Cys Asn Cys Gly Gly Gly Pro Cys Asp Ser Val Thr Gly Glu Cys Leu 
                245                 250                 255     


Glu Glu Gly Phe Glu Pro Pro Thr Gly Cys Asp Lys Cys Val Trp Asp 
            260                 265                 270         


Leu Thr Asp Asp Leu Arg Leu Ala Ala Leu Ser Ile Glu Glu Gly Lys 
        275                 280                 285             


Ser Gly Val Leu Ser Val Ser Ser Gly Ala Ala Ala His Arg His Val 
    290                 295                 300                 


Asn Glu Ile Asn Ala Thr Ile Tyr Leu Leu Lys Thr Lys Leu Ser Glu 
305                 310                 315                 320 


Arg Glu Asn Gln Tyr Ala Leu Arg Lys Ile Gln Ile Asn Asn Ala Glu 
                325                 330                 335     


Asn Thr Met Lys Ser Leu Leu Ser Asp Val Glu Glu Leu Val Glu Lys 
            340                 345                 350         


Glu Asn Gln Ala Ser Arg Lys Gly Gln Leu Val Gln Lys Glu Ser Met 
        355                 360                 365             


Asp Thr Ile Asn His Ala Ser Gln Leu Val Glu Gln Ala His Asp Met 
    370                 375                 380                 


Arg Asp Lys Ile Gln Glu Ile Asn Asn Lys Met Leu Tyr Tyr Gly Glu 
385                 390                 395                 400 


Glu His Glu Leu Ser Pro Lys Glu Ile Ser Glu Lys Leu Val Leu Ala 
                405                 410                 415     


Gln Lys Met Leu Glu Glu Ile Arg Ser Arg Gln Pro Phe Phe Thr Gln 
            420                 425                 430         


Arg Glu Leu Val Asp Glu Glu Ala Asp Glu Ala Tyr Glu Leu Leu Ser 
        435                 440                 445             


Gln Ala Glu Ser Trp Gln Arg Leu His Asn Glu Thr Arg Thr Leu Phe 
    450                 455                 460                 


Pro Val Val Leu Glu Gln Leu Asp Asp Tyr Asn Ala Lys Leu Ser Asp 
465                 470                 475                 480 


Leu Gln Glu Ala Leu Asp Gln Ala Leu Asn Tyr Val Arg Asp Ala Glu 
                485                 490                 495     


Asp Met Asn Arg Ala Thr Ala Ala Arg Gln Arg Asp His Glu Lys Gln 
            500                 505                 510         


Gln Glu Arg Val Arg Glu Gln Met Glu Val Val Asn Met Ser Leu Ser 
        515                 520                 525             


Thr Ser Ala Asp Ser Leu Thr Thr Pro Arg Leu Thr Leu Ser Glu Leu 
    530                 535                 540                 


Asp Asp Ile Ile Lys Asn Ala Ser Gly Ile Tyr Ala Glu Ile Asp Gly 
545                 550                 555                 560 


Ala Lys Ser Glu Leu Gln Val Lys Leu Ser Asn Leu Ser Asn Leu Ser 
                565                 570                 575     


His Asp Leu Val Gln Glu Ala Ile Asp His Ala Gln Asp Leu Gln Gln 
            580                 585                 590         


Glu Ala Asn Glu Leu Ser Arg Lys Leu His Ser Ser Asp Met Asn Gly 
        595                 600                 605             


Leu Val Gln Lys Ala Leu Asp Ala Ser Asn Val Tyr Glu Asn Ile Val 
    610                 615                 620                 


Asn Tyr Val Ser Glu Ala Asn Glu Thr Ala Glu Phe Ala Leu Asn Thr 
625                 630                 635                 640 


Thr Asp Arg Ile Tyr Asp Ala Val Ser Gly Ile Asp Thr Gln Ile Ile 
                645                 650                 655     


Tyr His Lys Asp Glu Ser Glu Asn Leu Leu Asn Gln Ala Arg Glu Leu 
            660                 665                 670         


Gln Ala Lys Ala Glu Ser Ser Ser Asp Glu Ala Val Ala Asp Thr Ser 
        675                 680                 685             


Arg Arg Val Gly Gly Ala Leu Ala Arg Lys Ser Ala Leu Lys Thr Arg 
    690                 695                 700                 


Leu Ser Asp Ala Val Lys Gln Leu Gln Ala Ala Glu Arg Gly Asp Ala 
705                 710                 715                 720 


Gln Gln Arg Leu Gly Gln Ser Arg Leu Ile Thr Glu Glu Ala Asn Arg 
                725                 730                 735     


Thr Thr Met Glu Val Gln Gln Ala Thr Ala Pro Met Ala Asn Asn Leu 
            740                 745                 750         


Thr Asn Trp Ser Gln Asn Leu Gln His Phe Asp Ser Ser Ala Tyr Asn 
        755                 760                 765             


Thr Ala Val Asn Ser Ala Arg Asp Ala Val Arg Asn Leu Thr Glu Val 
    770                 775                 780                 


Val Pro Gln Leu Leu Asp Gln Leu Arg Thr Val Glu Gln Lys Arg Pro 
785                 790                 795                 800 


Ala Ser Asn Val Ser Ala Ser Ile Gln Arg Ile Arg Glu Leu Ile Ala 
                805                 810                 815     


Gln Thr Arg Ser Val Ala Ser Lys Ile Gln Val Ser Met Met Phe Asp 
            820                 825                 830         


Gly Gln Ser Ala Val Glu Val His Ser Arg Thr Ser Met Asp Asp Leu 
        835                 840                 845             


Lys Ala Phe Thr Ser Leu Ser Leu Tyr Met Lys Pro Pro Val Lys Arg 
    850                 855                 860                 


Pro Glu Leu Thr Glu Thr Ala Asp Gln Phe Ile Leu Tyr Leu Gly Ser 
865                 870                 875                 880 


Lys Asn Ala Lys Lys Glu Tyr Met Gly Leu Ala Ile Lys Asn Asp Asn 
                885                 890                 895     


Leu Val Tyr Val Tyr Asn Leu Gly Thr Lys Asp Val Glu Ile Pro Leu 
            900                 905                 910         


Asp Ser Lys Pro Val Ser Ser Trp Pro Ala Tyr Phe Ser Ile Val Lys 
        915                 920                 925             


Ile Glu Arg Val Gly Lys His Gly Lys Val Phe Leu Thr Val Pro Ser 
    930                 935                 940                 


Leu Ser Ser Thr Ala Glu Glu Lys Phe Ile Lys Lys Gly Glu Phe Ser 
945                 950                 955                 960 


Gly Asp Asp Ser Leu Leu Asp Leu Asp Pro Glu Asp Thr Val Phe Tyr 
                965                 970                 975     


Val Gly Gly Val Pro Ser Asn Phe Lys Leu Pro Thr Ser Leu Asn Leu 
            980                 985                 990         


Pro Gly Phe Val Gly Cys Leu Glu  Leu Ala Thr Leu Asn  Asn Asp Val 
        995                 1000                 1005             


Ile Ser  Leu Tyr Asn Phe Lys  His Ile Tyr Asn Met  Asp Pro Ser 
    1010                 1015                 1020             


Thr Ser  Val Pro Cys Ala Arg  Asp Lys Leu Ala Phe  Thr Gln Ser 
    1025                 1030                 1035             


Arg Ala  Ala Ser Tyr Phe Phe  Asp Gly Ser Gly Tyr  Ala Val Val 
    1040                 1045                 1050             


Arg Asp  Ile Thr Arg Arg Gly  Lys Phe Gly Gln Val  Thr Arg Phe 
    1055                 1060                 1065             


Asp Ile  Glu Val Arg Thr Pro  Ala Asp Asn Gly Leu  Ile Leu Leu 
    1070                 1075                 1080             


Met Val  Asn Gly Ser Met Phe  Phe Arg Leu Glu Met  Arg Asn Gly 
    1085                 1090                 1095             


Tyr Leu  His Val Phe Tyr Asp  Phe Gly Phe Ser Gly  Gly Pro Val 
    1100                 1105                 1110             


His Leu  Glu Asp Thr Leu Lys  Lys Ala Gln Ile Asn  Asp Ala Lys 
    1115                 1120                 1125             


Tyr His  Glu Ile Ser Ile Ile  Tyr His Asn Asp Lys  Lys Met Ile 
    1130                 1135                 1140             


Leu Val  Val Asp Arg Arg His  Val Lys Ser Met Asp  Asn Glu Lys 
    1145                 1150                 1155             


Met Lys  Ile Pro Phe Thr Asp  Ile Tyr Ile Gly Gly  Ala Pro Pro 
    1160                 1165                 1170             


Glu Ile  Leu Gln Ser Arg Ala  Leu Arg Ala His Leu  Pro Leu Asp 
    1175                 1180                 1185             


Ile Asn  Phe Arg Gly Cys Met  Lys Gly Phe Gln Phe  Gln Lys Lys 
    1190                 1195                 1200             


Asp Phe  Asn Leu Leu Glu Gln  Thr Glu Thr Leu Gly  Val Gly Tyr 
    1205                 1210                 1215             


Gly Cys  Pro Glu Asp Ser Leu  Ile Ser Arg Arg Ala  Tyr Phe Asn 
    1220                 1225                 1230             


Gly Gln  Ser Phe Ile Ala Ser  Ile Gln Lys Ile Ser  Phe Phe Asp 
    1235                 1240                 1245             


Gly Phe  Glu Gly Gly Phe Asn  Phe Arg Thr Leu Gln  Pro Asn Gly 
    1250                 1255                 1260             


Leu Leu  Phe Tyr Tyr Ala Ser  Gly Ser Asp Val Phe  Ser Ile Ser 
    1265                 1270                 1275             


Leu Asp  Asn Gly Thr Val Ile  Met Asp Val Lys Gly  Ile Lys Val 
    1280                 1285                 1290             


Gln Ser  Val Asp Lys Gln Tyr  Asn Asp Gly Leu Ser  His Phe Val 
    1295                 1300                 1305             


Ile Ser  Ser Val Ser Pro Thr  Arg Tyr Glu Leu Ile  Val Asp Lys 
    1310                 1315                 1320             


Ser Arg  Val Gly Ser Lys Asn  Pro Thr Lys Gly Lys  Ile Glu Gln 
    1325                 1330                 1335             


Thr Gln  Ala Ser Glu Lys Lys  Phe Tyr Phe Gly Gly  Ser Pro Ile 
    1340                 1345                 1350             


Ser Ala  Gln Tyr Ala Asn Phe  Thr Gly Cys Ile Ser  Asn Ala Tyr 
    1355                 1360                 1365             


Phe Thr  Arg Val Asp Arg Asp  Val Glu Val Glu Asp  Phe Gln Arg 
    1370                 1375                 1380             


Tyr Thr  Glu Lys Val His Thr  Ser Leu Tyr Glu Cys  Pro Ile Glu 
    1385                 1390                 1395             


Ser Ser  Pro Leu Phe Leu Leu  His Lys Lys Gly Lys  Asn Leu Ser 
    1400                 1405                 1410             


Lys Pro  Lys Ala Ser Gln Asn  Lys Lys Gly Gly Lys  Ser Lys Asp 
    1415                 1420                 1425             


Ala Pro  Ser Trp Asp Pro Val  Ala Leu Lys Leu Pro  Glu Arg Asn 
    1430                 1435                 1440             


Thr Pro  Arg Asn Ser His Cys  His Leu Ser Asn Ser  Pro Arg Ala 
    1445                 1450                 1455             


Ile Glu  His Ala Tyr Gln Tyr  Gly Gly Thr Ala Asn  Ser Arg Gln 
    1460                 1465                 1470             


Glu Phe  Glu His Leu Lys Gly  Asp Phe Gly Ala Lys  Ser Gln Phe 
    1475                 1480                 1485             


Ser Ile  Arg Leu Arg Thr Arg  Ser Ser His Gly Met  Ile Phe Tyr 
    1490                 1495                 1500             


Val Ser  Asp Gln Glu Glu Asn  Asp Phe Met Thr Leu  Phe Leu Ala 
    1505                 1510                 1515             


His Gly  Arg Leu Val Tyr Met  Phe Asn Val Gly His  Lys Lys Leu 
    1520                 1525                 1530             


Lys Ile  Arg Ser Gln Glu Lys  Tyr Asn Asp Gly Leu  Trp His Asp 
    1535                 1540                 1545             


Val Ile  Phe Ile Arg Glu Arg  Ser Ser Gly Arg Leu  Val Ile Asp 
    1550                 1555                 1560             


Gly Leu  Arg Val Leu Glu Glu  Ser Leu Pro Pro Thr  Glu Ala Thr 
    1565                 1570                 1575             


Trp Lys  Ile Lys Gly Pro Ile  Tyr Leu Gly Gly Val  Ala Pro Gly 
    1580                 1585                 1590             


Lys Ala  Val Lys Asn Val Gln  Ile Asn Ser Ile Tyr  Ser Phe Ser 
    1595                 1600                 1605             


Gly Cys  Leu Ser Asn Leu Gln  Leu Asn Gly Ala Ser  Ile Thr Ser 
    1610                 1615                 1620             


Ala Ser  Gln Thr Phe Ser Val  Thr Pro Cys Phe Glu  Gly Pro Met 
    1625                 1630                 1635             


Glu Thr  Gly Thr Tyr Phe Ser  Thr Glu Gly Gly Tyr  Val Val Leu 
    1640                 1645                 1650             


Asp Glu  Ser Phe Asn Ile Gly  Leu Lys Phe Glu Ile  Ala Phe Glu 
    1655                 1660                 1665             


Val Arg  Pro Arg Ser Ser Ser  Gly Thr Leu Val His  Gly His Ser 
    1670                 1675                 1680             


Val Asn  Gly Glu Tyr Leu Asn  Val His Met Lys Asn  Gly Gln Val 
    1685                 1690                 1695             


Ile Val  Lys Val Asn Asn Gly  Ile Arg Asp Phe Ser  Thr Ser Val 
    1700                 1705                 1710             


Thr Pro  Lys Gln Ser Leu Cys  Asp Gly Arg Trp His  Arg Ile Thr 
    1715                 1720                 1725             


Val Ile  Arg Asp Ser Asn Val  Val Gln Leu Asp Val  Asp Ser Glu 
    1730                 1735                 1740             


Val Asn  His Val Val Gly Pro  Leu Asn Pro Lys Pro  Ile Asp His 
    1745                 1750                 1755             


Arg Glu  Pro Val Phe Val Gly  Gly Val Pro Glu Ser  Leu Leu Thr 
    1760                 1765                 1770             


Pro Arg  Leu Ala Pro Ser Lys  Pro Phe Thr Gly Cys  Ile Arg His 
    1775                 1780                 1785             


Phe Val  Ile Asp Gly His Pro  Val Ser Phe Ser Lys  Ala Ala Leu 
    1790                 1795                 1800             


Val Ser  Gly Ala Val Ser Ile  Asn Ser Cys Pro Ala  Ala 
    1805                 1810                 1815     


<210>  7663
<211>  1816
<212>  PRT
<213>  Homo Sapiens

<400>  7663

Met Ala Leu Ser Ser Ala Trp Arg Ser Val Leu Pro Leu Trp Leu Leu 
1               5                   10                  15      


Trp Ser Ala Ala Cys Ser Arg Ala Ala Ser Gly Asp Asp Asn Ala Phe 
            20                  25                  30          


Pro Phe Asp Ile Glu Gly Ser Ser Ala Val Gly Arg Gln Asp Pro Pro 
        35                  40                  45              


Glu Thr Ser Glu Pro Arg Val Ala Leu Gly Arg Leu Pro Pro Ala Ala 
    50                  55                  60                  


Glu Lys Cys Asn Ala Gly Phe Phe His Thr Leu Ser Gly Glu Cys Val 
65                  70                  75                  80  


Pro Cys Asp Cys Asn Gly Asn Ser Asn Glu Cys Leu Asp Gly Ser Gly 
                85                  90                  95      


Tyr Cys Val His Cys Gln Arg Asn Thr Thr Gly Glu His Cys Glu Lys 
            100                 105                 110         


Cys Leu Asp Gly Tyr Ile Gly Asp Ser Ile Arg Gly Ala Pro Gln Phe 
        115                 120                 125             


Cys Gln Pro Cys Pro Cys Pro Leu Pro His Leu Ala Asn Phe Ala Glu 
    130                 135                 140                 


Ser Cys Tyr Arg Lys Asn Gly Ala Val Arg Cys Ile Cys Asn Glu Asn 
145                 150                 155                 160 


Tyr Ala Gly Pro Asn Cys Glu Arg Cys Ala Pro Gly Tyr Tyr Gly Asn 
                165                 170                 175     


Pro Leu Leu Ile Gly Ser Thr Cys Lys Lys Cys Asp Cys Ser Gly Asn 
            180                 185                 190         


Ser Asp Pro Asn Leu Ile Phe Glu Asp Cys Asp Glu Val Thr Gly Gln 
        195                 200                 205             


Cys Arg Asn Cys Leu Arg Asn Thr Thr Gly Phe Lys Cys Glu Arg Cys 
    210                 215                 220                 


Ala Pro Gly Tyr Tyr Gly Asp Ala Arg Ile Ala Lys Asn Cys Ala Val 
225                 230                 235                 240 


Cys Asn Cys Gly Gly Gly Pro Cys Asp Ser Val Thr Gly Glu Cys Leu 
                245                 250                 255     


Glu Glu Gly Phe Glu Pro Pro Thr Gly Cys Asp Lys Cys Val Trp Asp 
            260                 265                 270         


Leu Thr Asp Asp Leu Arg Leu Ala Ala Leu Ser Ile Glu Glu Gly Lys 
        275                 280                 285             


Ser Gly Val Leu Ser Val Ser Ser Gly Ala Ala Ala His Arg His Val 
    290                 295                 300                 


Asn Glu Ile Asn Ala Thr Ile Tyr Leu Leu Lys Thr Lys Leu Ser Glu 
305                 310                 315                 320 


Arg Glu Asn Gln Tyr Ala Leu Arg Lys Ile Gln Ile Asn Asn Ala Glu 
                325                 330                 335     


Asn Thr Met Lys Ser Leu Leu Ser Asp Val Glu Glu Leu Val Glu Lys 
            340                 345                 350         


Glu Asn Gln Ala Ser Arg Lys Gly Gln Leu Val Gln Lys Glu Ser Met 
        355                 360                 365             


Asp Thr Ile Asn His Ala Ser Gln Leu Val Glu Gln Ala His Asp Met 
    370                 375                 380                 


Arg Asp Lys Ile Gln Glu Ile Asn Asn Lys Met Leu Tyr Tyr Gly Glu 
385                 390                 395                 400 


Glu His Glu Leu Ser Pro Lys Glu Ile Ser Glu Lys Leu Val Leu Ala 
                405                 410                 415     


Gln Lys Met Leu Glu Glu Ile Arg Ser Arg Gln Pro Phe Phe Thr Gln 
            420                 425                 430         


Arg Glu Leu Val Asp Glu Glu Ala Asp Glu Ala Tyr Glu Leu Leu Ser 
        435                 440                 445             


Gln Ala Glu Ser Trp Gln Arg Leu His Asn Glu Thr Arg Thr Leu Phe 
    450                 455                 460                 


Pro Val Val Leu Glu Gln Leu Asp Asp Tyr Asn Ala Lys Leu Ser Asp 
465                 470                 475                 480 


Leu Gln Glu Ala Leu Asp Gln Ala Leu Asn Tyr Val Arg Asp Ala Glu 
                485                 490                 495     


Asp Met Asn Arg Ala Thr Ala Ala Arg Gln Arg Asp His Glu Lys Gln 
            500                 505                 510         


Gln Glu Arg Val Arg Glu Gln Met Glu Val Val Asn Met Ser Leu Ser 
        515                 520                 525             


Thr Ser Ala Asp Ser Leu Thr Thr Pro Arg Leu Thr Leu Ser Glu Leu 
    530                 535                 540                 


Asp Asp Ile Ile Lys Asn Ala Ser Gly Ile Tyr Ala Glu Ile Asp Gly 
545                 550                 555                 560 


Ala Lys Ser Glu Leu Gln Val Lys Leu Ser Asn Leu Ser Asn Leu Ser 
                565                 570                 575     


His Asp Leu Val Gln Glu Ala Ile Asp His Ala Gln Asp Leu Gln Gln 
            580                 585                 590         


Glu Ala Asn Glu Leu Ser Arg Lys Leu His Ser Ser Asp Met Asn Gly 
        595                 600                 605             


Leu Val Gln Lys Ala Leu Asp Ala Ser Asn Val Tyr Glu Asn Ile Val 
    610                 615                 620                 


Asn Tyr Val Ser Glu Ala Asn Glu Thr Ala Glu Phe Ala Leu Asn Thr 
625                 630                 635                 640 


Thr Asp Arg Ile Tyr Asp Ala Val Ser Gly Ile Asp Thr Gln Ile Ile 
                645                 650                 655     


Tyr His Lys Asp Glu Ser Glu Asn Leu Leu Asn Gln Ala Arg Glu Leu 
            660                 665                 670         


Gln Ala Lys Ala Glu Ser Ser Ser Asp Glu Ala Val Ala Asp Thr Ser 
        675                 680                 685             


Arg Arg Val Gly Gly Ala Leu Ala Arg Lys Ser Ala Leu Lys Thr Arg 
    690                 695                 700                 


Leu Ser Asp Ala Val Lys Gln Leu Gln Ala Ala Glu Arg Gly Asp Ala 
705                 710                 715                 720 


Gln Gln Arg Leu Gly Gln Ser Arg Leu Ile Thr Glu Glu Ala Asn Arg 
                725                 730                 735     


Thr Thr Met Glu Val Gln Gln Ala Thr Ala Pro Met Ala Asn Asn Leu 
            740                 745                 750         


Thr Asn Trp Ser Gln Asn Leu Gln His Phe Asp Ser Ser Ala Tyr Asn 
        755                 760                 765             


Thr Ala Val Asn Ser Ala Arg Asp Ala Val Arg Asn Leu Thr Glu Val 
    770                 775                 780                 


Val Pro Gln Leu Leu Asp Gln Leu Arg Thr Val Glu Gln Lys Arg Pro 
785                 790                 795                 800 


Ala Ser Asn Val Ser Ala Ser Ile Gln Arg Ile Arg Glu Leu Ile Ala 
                805                 810                 815     


Gln Thr Arg Ser Val Ala Ser Lys Ile Gln Val Ser Met Met Phe Asp 
            820                 825                 830         


Gly Gln Ser Ala Val Glu Val His Ser Arg Thr Ser Met Asp Asp Leu 
        835                 840                 845             


Lys Ala Phe Thr Ser Leu Ser Leu Tyr Met Lys Pro Pro Val Lys Arg 
    850                 855                 860                 


Pro Glu Leu Thr Glu Thr Ala Asp Gln Phe Ile Leu Tyr Leu Gly Ser 
865                 870                 875                 880 


Lys Asn Ala Lys Lys Glu Tyr Met Gly Leu Ala Ile Lys Asn Asp Asn 
                885                 890                 895     


Leu Val Tyr Val Tyr Asn Leu Gly Thr Lys Asp Val Glu Ile Pro Leu 
            900                 905                 910         


Asp Ser Lys Pro Val Ser Ser Trp Pro Ala Tyr Phe Ser Ile Val Lys 
        915                 920                 925             


Ile Glu Arg Val Gly Lys His Gly Lys Val Phe Leu Thr Val Pro Ser 
    930                 935                 940                 


Leu Ser Ser Thr Ala Glu Glu Lys Phe Ile Lys Lys Gly Glu Phe Ser 
945                 950                 955                 960 


Gly Asp Asp Ser Leu Leu Asp Leu Asp Pro Glu Asp Thr Val Phe Tyr 
                965                 970                 975     


Val Gly Gly Val Pro Ser Asn Phe Lys Leu Pro Thr Ser Leu Asn Leu 
            980                 985                 990         


Pro Gly Phe Val Gly Cys Leu Glu  Leu Ala Thr Leu Asn  Asn Asp Val 
        995                 1000                 1005             


Ile Ser  Leu Tyr Asn Phe Lys  His Ile Tyr Asn Met  Asp Pro Ser 
    1010                 1015                 1020             


Thr Ser  Val Pro Cys Ala Arg  Asp Lys Leu Ala Phe  Thr Gln Ser 
    1025                 1030                 1035             


Arg Ala  Ala Ser Tyr Phe Phe  Asp Gly Ser Gly Tyr  Ala Val Val 
    1040                 1045                 1050             


Arg Asp  Ile Thr Arg Arg Gly  Lys Phe Gly Gln Val  Thr Arg Phe 
    1055                 1060                 1065             


Asp Ile  Glu Val Arg Thr Pro  Ala Asp Asn Gly Leu  Ile Leu Leu 
    1070                 1075                 1080             


Met Val  Asn Gly Ser Met Phe  Phe Arg Leu Glu Met  Arg Asn Gly 
    1085                 1090                 1095             


Tyr Leu  His Val Phe Tyr Asp  Phe Gly Phe Ser Gly  Gly Pro Val 
    1100                 1105                 1110             


His Leu  Glu Asp Thr Leu Lys  Lys Ala Gln Ile Asn  Asp Ala Lys 
    1115                 1120                 1125             


Tyr His  Glu Ile Ser Ile Ile  Tyr His Asn Asp Lys  Lys Met Ile 
    1130                 1135                 1140             


Leu Val  Val Asp Arg Arg His  Val Lys Ser Met Asp  Asn Glu Lys 
    1145                 1150                 1155             


Met Lys  Ile Pro Phe Thr Asp  Ile Tyr Ile Gly Gly  Ala Pro Pro 
    1160                 1165                 1170             


Glu Ile  Leu Gln Ser Arg Ala  Leu Arg Ala His Leu  Pro Leu Asp 
    1175                 1180                 1185             


Ile Asn  Phe Arg Gly Cys Met  Lys Gly Phe Gln Phe  Gln Lys Lys 
    1190                 1195                 1200             


Asp Phe  Asn Leu Leu Glu Gln  Thr Glu Thr Leu Gly  Val Gly Tyr 
    1205                 1210                 1215             


Gly Cys  Pro Glu Asp Ser Leu  Ile Ser Arg Arg Ala  Tyr Phe Asn 
    1220                 1225                 1230             


Gly Gln  Ser Phe Ile Ala Ser  Ile Gln Lys Ile Ser  Phe Phe Asp 
    1235                 1240                 1245             


Gly Phe  Glu Gly Gly Phe Asn  Phe Arg Thr Leu Gln  Pro Asn Gly 
    1250                 1255                 1260             


Leu Leu  Phe Tyr Tyr Ala Ser  Gly Ser Asp Val Phe  Ser Ile Ser 
    1265                 1270                 1275             


Leu Asp  Asn Gly Thr Val Ile  Met Asp Val Lys Gly  Ile Lys Val 
    1280                 1285                 1290             


Gln Ser  Val Asp Lys Gln Tyr  Asn Asp Gly Leu Ser  His Phe Val 
    1295                 1300                 1305             


Ile Ser  Ser Val Ser Pro Thr  Arg Tyr Glu Leu Ile  Val Asp Lys 
    1310                 1315                 1320             


Ser Arg  Val Gly Ser Lys Asn  Pro Thr Lys Gly Lys  Ile Glu Gln 
    1325                 1330                 1335             


Thr Gln  Ala Ser Glu Lys Lys  Phe Tyr Phe Gly Gly  Ser Pro Ile 
    1340                 1345                 1350             


Ser Ala  Gln Tyr Ala Asn Phe  Thr Gly Cys Ile Ser  Asn Ala Tyr 
    1355                 1360                 1365             


Phe Thr  Arg Val Asp Arg Asp  Val Glu Val Glu Asp  Phe Gln Arg 
    1370                 1375                 1380             


Tyr Thr  Glu Lys Val His Thr  Ser Leu Tyr Glu Cys  Pro Ile Glu 
    1385                 1390                 1395             


Ser Ser  Pro Leu Phe Leu Leu  His Lys Lys Gly Lys  Asn Leu Ser 
    1400                 1405                 1410             


Lys Pro  Lys Ala Ser Gln Asn  Lys Lys Gly Gly Lys  Ser Lys Asp 
    1415                 1420                 1425             


Ala Pro  Ser Trp Asp Pro Val  Ala Leu Lys Leu Pro  Glu Arg Asn 
    1430                 1435                 1440             


Thr Pro  Arg Asn Ser His Cys  His Leu Ser Asn Ser  Pro Arg Ala 
    1445                 1450                 1455             


Ile Glu  His Ala Tyr Gln Tyr  Gly Gly Thr Ala Asn  Ser Arg Gln 
    1460                 1465                 1470             


Glu Phe  Glu His Leu Lys Gly  Asp Phe Gly Ala Lys  Ser Gln Phe 
    1475                 1480                 1485             


Ser Ile  Arg Leu Arg Thr Arg  Ser Ser His Gly Met  Ile Phe Tyr 
    1490                 1495                 1500             


Val Ser  Asp Gln Glu Glu Asn  Asp Phe Met Thr Leu  Phe Leu Ala 
    1505                 1510                 1515             


His Gly  Arg Leu Val Tyr Met  Phe Asn Val Gly His  Lys Lys Leu 
    1520                 1525                 1530             


Lys Ile  Arg Ser Gln Glu Lys  Tyr Asn Asp Gly Leu  Trp His Asp 
    1535                 1540                 1545             


Val Ile  Phe Ile Arg Glu Arg  Ser Ser Gly Arg Leu  Val Ile Asp 
    1550                 1555                 1560             


Gly Leu  Arg Val Leu Glu Glu  Ser Leu Pro Pro Thr  Glu Ala Thr 
    1565                 1570                 1575             


Trp Lys  Ile Lys Gly Pro Ile  Tyr Leu Gly Gly Val  Ala Pro Gly 
    1580                 1585                 1590             


Lys Ala  Val Lys Asn Val Gln  Ile Asn Ser Ile Tyr  Ser Phe Ser 
    1595                 1600                 1605             


Gly Cys  Leu Ser Asn Leu Gln  Leu Asn Gly Ala Ser  Ile Thr Ser 
    1610                 1615                 1620             


Ala Ser  Gln Thr Phe Ser Val  Thr Pro Cys Phe Glu  Gly Pro Met 
    1625                 1630                 1635             


Glu Thr  Gly Thr Tyr Phe Ser  Thr Glu Gly Gly Tyr  Val Val Leu 
    1640                 1645                 1650             


Asp Glu  Ser Phe Asn Ile Gly  Leu Lys Phe Glu Ile  Ala Phe Glu 
    1655                 1660                 1665             


Val Arg  Pro Arg Ser Ser Ser  Gly Thr Leu Val His  Gly His Ser 
    1670                 1675                 1680             


Val Asn  Gly Glu Tyr Leu Asn  Val His Met Lys Asn  Gly Gln Val 
    1685                 1690                 1695             


Ile Val  Lys Val Asn Asn Gly  Ile Arg Asp Phe Ser  Thr Ser Val 
    1700                 1705                 1710             


Thr Pro  Lys Gln Ser Leu Cys  Asp Gly Arg Trp His  Arg Ile Thr 
    1715                 1720                 1725             


Val Ile  Arg Asp Ser Asn Val  Val Gln Leu Asp Val  Asp Ser Glu 
    1730                 1735                 1740             


Val Asn  His Val Val Gly Pro  Leu Asn Pro Lys Pro  Ile Asp His 
    1745                 1750                 1755             


Arg Glu  Pro Val Phe Val Gly  Gly Val Pro Glu Ser  Leu Leu Thr 
    1760                 1765                 1770             


Pro Arg  Leu Ala Pro Ser Lys  Pro Phe Thr Gly Cys  Ile Arg His 
    1775                 1780                 1785             


Phe Val  Ile Asp Gly His Pro  Val Ser Phe Ser Lys  Ala Ala Leu 
    1790                 1795                 1800             


Val Ser  Gly Ala Val Ser Ile  Asn Ser Cys Pro Ala  Ala 
    1805                 1810                 1815     


<210>  7664
<211>  331
<212>  PRT
<213>  Homo Sapiens

<400>  7664

Met Ala Leu Ser Ser Ala Trp Arg Ser Val Leu Pro Leu Trp Leu Leu 
1               5                   10                  15      


Trp Ser Ala Ala Cys Ser Arg Ala Ala Ser Gly Asp Asp Asn Ala Phe 
            20                  25                  30          


Pro Phe Asp Ile Glu Gly Ser Ser Ala Val Gly Arg Gln Asp Pro Pro 
        35                  40                  45              


Glu Thr Ser Glu Pro Arg Val Ala Leu Gly Arg Leu Pro Pro Ala Ala 
    50                  55                  60                  


Glu Lys Cys Asn Ala Gly Phe Phe His Thr Leu Ser Gly Glu Cys Val 
65                  70                  75                  80  


Pro Cys Asp Cys Asn Gly Asn Ser Asn Glu Cys Leu Asp Gly Ser Gly 
                85                  90                  95      


Tyr Cys Val His Cys Gln Arg Asn Thr Thr Gly Glu His Cys Glu Lys 
            100                 105                 110         


Cys Leu Asp Gly Tyr Ile Gly Asp Ser Ile Arg Gly Ala Pro Gln Phe 
        115                 120                 125             


Cys Gln Pro Cys Pro Cys Pro Leu Pro His Leu Ala Asn Phe Ala Glu 
    130                 135                 140                 


Ser Cys Tyr Arg Lys Asn Gly Ala Val Arg Cys Ile Cys Asn Glu Asn 
145                 150                 155                 160 


Tyr Ala Gly Pro Asn Cys Glu Arg Cys Ala Pro Gly Tyr Tyr Gly Asn 
                165                 170                 175     


Pro Leu Leu Ile Gly Ser Thr Cys Lys Lys Cys Asp Cys Ser Gly Asn 
            180                 185                 190         


Ser Asp Pro Asn Leu Ile Phe Glu Asp Cys Asp Glu Val Thr Gly Gln 
        195                 200                 205             


Cys Arg Asn Cys Leu Arg Asn Thr Thr Gly Phe Lys Cys Glu Arg Cys 
    210                 215                 220                 


Ala Pro Gly Tyr Tyr Gly Asp Ala Arg Ile Ala Lys Asn Cys Ala Val 
225                 230                 235                 240 


Cys Asn Cys Gly Gly Gly Pro Cys Asp Ser Val Thr Gly Glu Cys Leu 
                245                 250                 255     


Glu Glu Gly Phe Glu Pro Pro Thr Gly Met Asp Cys Pro Thr Ile Ser 
            260                 265                 270         


Cys Asp Lys Cys Val Trp Asp Leu Thr Asp Asp Leu Arg Leu Ala Ala 
        275                 280                 285             


Leu Ser Ile Glu Glu Gly Lys Ser Gly Val Leu Ser Val Ser Ser Gly 
    290                 295                 300                 


Ala Ala Ala His Arg His Val Asn Glu Ile Asn Ala Thr Ile Tyr Leu 
305                 310                 315                 320 


Leu Lys Thr Lys Leu Ser Glu Arg Glu Asn Gln 
                325                 330     


<210>  7665
<211>  129
<212>  PRT
<213>  Homo Sapiens

<400>  7665

Met Ala Leu Ser Ser Ala Trp Arg Ser Val Leu Pro Leu Trp Leu Leu 
1               5                   10                  15      


Trp Ser Ala Ala Cys Ser Arg Ala Ala Ser Gly Asp Asp Asn Ala Phe 
            20                  25                  30          


Pro Phe Asp Ile Glu Gly Ser Ser Ala Val Gly Arg Gln Asp Pro Pro 
        35                  40                  45              


Glu Thr Ser Glu Pro Arg Val Ala Leu Gly Arg Leu Pro Pro Ala Ala 
    50                  55                  60                  


Glu Lys Cys Asn Ala Gly Phe Phe His Thr Leu Ser Gly Glu Cys Val 
65                  70                  75                  80  


Pro Cys Asp Cys Asn Gly Asn Ser Asn Glu Cys Leu Asp Gly Ser Gly 
                85                  90                  95      


Tyr Cys Val Thr Thr Asp Gly Glu Asp Pro Gly Phe Ser Ala Ser Ala 
            100                 105                 110         


Leu Ser Phe Ile Leu Ser Ser Gln Gly Ala Arg Glu Ala Arg Ala Pro 
        115                 120                 125             


Thr 
    


<210>  7666
<211>  120
<212>  PRT
<213>  Homo Sapiens

<400>  7666

Met Ala Leu Ser Ser Ala Trp Arg Ser Val Leu Pro Leu Trp Leu Leu 
1               5                   10                  15      


Trp Ser Ala Ala Cys Ser Arg Ala Ala Ser Gly Asp Asp Asn Ala Phe 
            20                  25                  30          


Pro Phe Asp Ile Glu Gly Ser Ser Ala Val Gly Arg Gln Asp Pro Pro 
        35                  40                  45              


Glu Thr Ser Glu Pro Arg Val Ala Leu Gly Arg Leu Pro Pro Ala Ala 
    50                  55                  60                  


Glu Val Gln Cys Pro Cys His Cys His Pro Ala Gly Ala Pro Ala Pro 
65                  70                  75                  80  


Pro Arg Ala Val Pro His Ser Ser Phe Ser Leu Ser Pro Pro Leu Ser 
                85                  90                  95      


Ser Pro Gln Cys Leu Glu Ser Phe Thr Trp Ala Arg Ser Val Arg Lys 
            100                 105                 110         


Leu Glu Ile Lys Ser Phe Pro Leu 
        115                 120 


<210>  7667
<211>  120
<212>  PRT
<213>  Homo Sapiens

<400>  7667

Met Ala Leu Ser Ser Ala Trp Arg Ser Val Leu Pro Leu Trp Leu Leu 
1               5                   10                  15      


Trp Ser Ala Ala Cys Ser Arg Ala Ala Ser Gly Asp Asp Asn Ala Phe 
            20                  25                  30          


Pro Phe Asp Ile Glu Gly Ser Ser Ala Val Gly Arg Gln Asp Pro Pro 
        35                  40                  45              


Glu Thr Ser Glu Pro Arg Val Ala Leu Gly Arg Leu Pro Pro Ala Ala 
    50                  55                  60                  


Glu Val Gln Cys Pro Cys His Cys His Pro Ala Gly Ala Pro Ala Pro 
65                  70                  75                  80  


Pro Arg Ala Val Pro His Ser Ser Phe Ser Leu Ser Pro Pro Leu Ser 
                85                  90                  95      


Ser Pro Gln Cys Leu Glu Ser Phe Thr Trp Ala Arg Ser Val Arg Lys 
            100                 105                 110         


Leu Glu Ile Lys Ser Phe Pro Leu 
        115                 120 


<210>  7668
<211>  120
<212>  PRT
<213>  Homo Sapiens

<400>  7668

Met Ala Leu Ser Ser Ala Trp Arg Ser Val Leu Pro Leu Trp Leu Leu 
1               5                   10                  15      


Trp Ser Ala Ala Cys Ser Arg Ala Ala Ser Gly Asp Asp Asn Ala Phe 
            20                  25                  30          


Pro Phe Asp Ile Glu Gly Ser Ser Ala Val Gly Arg Gln Asp Pro Pro 
        35                  40                  45              


Glu Thr Ser Glu Pro Arg Val Ala Leu Gly Arg Leu Pro Pro Ala Ala 
    50                  55                  60                  


Glu Val Gln Cys Pro Cys His Cys His Pro Ala Gly Ala Pro Ala Pro 
65                  70                  75                  80  


Pro Arg Ala Val Pro His Ser Ser Phe Ser Leu Ser Pro Pro Leu Ser 
                85                  90                  95      


Ser Pro Gln Cys Leu Glu Ser Phe Thr Trp Ala Arg Ser Val Arg Lys 
            100                 105                 110         


Leu Glu Ile Lys Ser Phe Pro Leu 
        115                 120 


<210>  7669
<211>  178
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7669

Xaa Ile Phe Glu Asp Cys Asp Glu Val Thr Gly Gln Cys Arg Asn Cys 
1               5                   10                  15      


Leu Arg Asn Thr Thr Gly Phe Lys Cys Glu Arg Cys Ala Pro Gly Tyr 
            20                  25                  30          


Tyr Gly Asp Ala Arg Ile Ala Lys Asn Cys Ala Val Cys Asn Cys Gly 
        35                  40                  45              


Gly Gly Pro Cys Asp Ser Val Thr Gly Glu Cys Leu Glu Glu Gly Phe 
    50                  55                  60                  


Glu Pro Pro Thr Gly Met Asp Cys Pro Thr Ile Ser Cys Asp Lys Cys 
65                  70                  75                  80  


Val Trp Asp Leu Thr Asp Asp Leu Arg Leu Ala Ala Leu Ser Ile Glu 
                85                  90                  95      


Glu Gly Lys Ser Gly Val Leu Ser Val Ser Ser Gly Ala Ala Ala His 
            100                 105                 110         


Arg His Val Asn Glu Ile Asn Ala Thr Ile Tyr Leu Leu Lys Thr Lys 
        115                 120                 125             


Leu Ser Glu Arg Glu Asn Gln Tyr Ala Leu Arg Lys Ile Gln Ile Asn 
    130                 135                 140                 


Asn Ala Glu Asn Thr Met Lys Ser Leu Leu Ser Asp Val Glu Glu Leu 
145                 150                 155                 160 


Val Glu Lys His Trp Asn Lys Pro Arg Arg Arg Leu Glu Leu Gln Glu 
                165                 170                 175     


Gly Val 
        


<210>  7670
<211>  188
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7670

Xaa Lys Asn Ala Ser Gly Ile Tyr Ala Glu Ile Asp Gly Ala Lys Ser 
1               5                   10                  15      


Glu Leu Gln Val Lys Leu Ser Asn Leu Ser Asn Leu Ser His Asp Leu 
            20                  25                  30          


Val Gln Glu Ala Ile Asp His Ala Gln Asp Leu Gln Gln Glu Ala Asn 
        35                  40                  45              


Glu Leu Ser Arg Lys Leu His Ser Ser Asp Met Asn Gly Leu Val Gln 
    50                  55                  60                  


Lys Ala Leu Asp Ala Ser Asn Val Tyr Glu Asn Ile Val Asn Tyr Val 
65                  70                  75                  80  


Ser Glu Ala Asn Glu Thr Ala Glu Phe Ala Leu Asn Thr Thr Asp Arg 
                85                  90                  95      


Ile Tyr Asp Ala Val Ser Gly Ile Asp Thr Gln Ile Ile Tyr His Lys 
            100                 105                 110         


Asp Glu Ser Glu Asn Leu Leu Asn Gln Ala Arg Glu Leu Gln Ala Lys 
        115                 120                 125             


Ala Glu Ser Ser Ser Asp Glu Ala Val Ala Asp Thr Ser Arg Arg Val 
    130                 135                 140                 


Gly Gly Ala Leu Ala Arg Lys Ser Ala Leu Lys Thr Arg Leu Ser Asp 
145                 150                 155                 160 


Ala Val Lys Gln Leu Gln Ala Ala Glu Arg Gly Lys His Gln Arg Glu 
                165                 170                 175     


Leu Lys Ser His Leu Leu Ile His Trp Ser Val Arg 
            180                 185             


<210>  7671
<211>  187
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7671

Xaa Ser Thr Cys Lys Lys Cys Asp Cys Ser Gly Asn Ser Asp Pro Asn 
1               5                   10                  15      


Leu Ile Phe Glu Asp Cys Asp Glu Val Thr Gly Gln Cys Arg Asn Cys 
            20                  25                  30          


Leu Arg Asn Thr Thr Gly Phe Lys Cys Glu Arg Cys Ala Pro Gly Tyr 
        35                  40                  45              


Tyr Gly Asp Ala Arg Ile Ala Lys Asn Cys Ala Val Cys Asn Cys Gly 
    50                  55                  60                  


Gly Gly Pro Cys Asp Ser Val Thr Gly Glu Cys Leu Glu Glu Gly Phe 
65                  70                  75                  80  


Glu Pro Pro Thr Gly Cys Asp Lys Cys Val Trp Asp Leu Thr Asp Asp 
                85                  90                  95      


Leu Arg Leu Ala Ala Leu Ser Ile Glu Glu Gly Lys Ser Gly Val Leu 
            100                 105                 110         


Ser Val Ser Ser Gly Ala Ala Ala His Arg His Val Asn Glu Ile Asn 
        115                 120                 125             


Ala Thr Ile Tyr Leu Leu Lys Thr Lys Leu Ser Glu Arg Glu Asn Gln 
    130                 135                 140                 


Tyr Ala Leu Arg Lys Ile Gln Ile Asn Asn Ala Glu Asn Thr Met Lys 
145                 150                 155                 160 


Ser Leu Leu Ser Asp Val Glu Glu Leu Val Glu Lys His Trp Asn Lys 
                165                 170                 175     


Pro Arg Arg Arg Leu Glu Leu Gln Glu Gly Val 
            180                 185         


<210>  7672
<211>  38
<212>  PRT
<213>  Homo Sapiens

<400>  7672

Cys Val Pro Gly Ala Tyr Asn Phe Pro Tyr Cys Glu Gly Ala Val Trp 
1               5                   10                  15      


Trp Asp Gly Thr Ser Val Ala Ala Glu Gly Ala Gly Arg Cys Val Phe 
            20                  25                  30          


Ser Gly Arg Pro Cys Gly 
        35              


<210>  7673
<211>  3695
<212>  PRT
<213>  Homo Sapiens

<400>  7673

Met Ala Lys Arg Leu Cys Ala Gly Ser Ala Leu Cys Val Arg Gly Pro 
1               5                   10                  15      


Arg Gly Pro Ala Pro Leu Leu Leu Val Gly Leu Ala Leu Leu Gly Ala 
            20                  25                  30          


Ala Arg Ala Arg Glu Glu Ala Gly Gly Gly Phe Ser Leu His Pro Pro 
        35                  40                  45              


Tyr Phe Asn Leu Ala Glu Gly Ala Arg Ile Ala Ala Ser Ala Thr Cys 
    50                  55                  60                  


Gly Glu Glu Ala Pro Ala Arg Gly Ser Pro Arg Pro Thr Glu Asp Leu 
65                  70                  75                  80  


Tyr Cys Lys Leu Val Gly Gly Pro Val Ala Gly Gly Asp Pro Asn Gln 
                85                  90                  95      


Thr Ile Arg Gly Gln Tyr Cys Asp Ile Cys Thr Ala Ala Asn Ser Asn 
            100                 105                 110         


Lys Ala His Pro Ala Ser Asn Ala Ile Asp Gly Thr Glu Arg Trp Trp 
        115                 120                 125             


Gln Ser Pro Pro Leu Ser Arg Gly Leu Glu Tyr Asn Glu Val Asn Val 
    130                 135                 140                 


Thr Leu Asp Leu Gly Gln Val Phe His Val Ala Tyr Val Leu Ile Lys 
145                 150                 155                 160 


Phe Ala Asn Ser Pro Arg Pro Asp Leu Trp Val Leu Glu Arg Ser Met 
                165                 170                 175     


Asp Phe Gly Arg Thr Tyr Gln Pro Trp Gln Phe Phe Ala Ser Ser Lys 
            180                 185                 190         


Arg Asp Cys Leu Glu Arg Phe Gly Pro Gln Thr Leu Glu Arg Ile Thr 
        195                 200                 205             


Arg Asp Asp Ala Ala Ile Cys Thr Thr Glu Tyr Ser Arg Ile Val Pro 
    210                 215                 220                 


Leu Glu Asn Gly Glu Ile Val Val Ser Leu Val Asn Gly Arg Pro Gly 
225                 230                 235                 240 


Ala Met Asn Phe Ser Tyr Ser Pro Leu Leu Arg Glu Phe Thr Lys Ala 
                245                 250                 255     


Thr Asn Val Arg Leu Arg Phe Leu Arg Thr Asn Thr Leu Leu Gly His 
            260                 265                 270         


Leu Met Gly Lys Ala Leu Arg Asp Pro Thr Val Thr Arg Arg Tyr Tyr 
        275                 280                 285             


Tyr Ser Ile Lys Asp Ile Ser Ile Gly Gly Arg Cys Val Cys His Gly 
    290                 295                 300                 


His Ala Asp Ala Cys Asp Ala Lys Asp Pro Thr Asp Pro Phe Arg Leu 
305                 310                 315                 320 


Gln Cys Thr Cys Gln His Asn Thr Cys Gly Gly Thr Cys Asp Arg Cys 
                325                 330                 335     


Cys Pro Gly Phe Asn Gln Gln Pro Trp Lys Pro Ala Thr Ala Asn Ser 
            340                 345                 350         


Ala Asn Glu Cys Gln Ser Cys Asn Cys Tyr Gly His Ala Thr Asp Cys 
        355                 360                 365             


Tyr Tyr Asp Pro Glu Val Asp Arg Arg Arg Ala Ser Gln Ser Leu Asp 
    370                 375                 380                 


Gly Thr Tyr Gln Gly Gly Gly Val Cys Ile Asp Cys Gln His His Thr 
385                 390                 395                 400 


Thr Gly Val Asn Cys Glu Arg Cys Leu Pro Gly Phe Tyr Arg Ser Pro 
                405                 410                 415     


Asn His Pro Leu Asp Ser Pro His Val Cys Arg Arg Cys Asn Cys Glu 
            420                 425                 430         


Ser Asp Phe Thr Asp Gly Thr Cys Glu Asp Leu Thr Gly Arg Cys Tyr 
        435                 440                 445             


Cys Arg Pro Asn Phe Ser Gly Glu Arg Cys Asp Val Cys Ala Glu Gly 
    450                 455                 460                 


Phe Thr Gly Phe Pro Ser Cys Tyr Pro Thr Pro Ser Ser Ser Asn Asp 
465                 470                 475                 480 


Thr Arg Glu Gln Val Leu Pro Ala Gly Gln Ile Val Asn Cys Asp Cys 
                485                 490                 495     


Ser Ala Ala Gly Thr Gln Gly Asn Ala Cys Arg Lys Asp Pro Arg Val 
            500                 505                 510         


Gly Arg Cys Leu Cys Lys Pro Asn Phe Gln Gly Thr His Cys Glu Leu 
        515                 520                 525             


Cys Ala Pro Gly Phe Tyr Gly Pro Gly Cys Gln Pro Cys Gln Cys Ser 
    530                 535                 540                 


Ser Pro Gly Val Ala Asp Asp Arg Cys Asp Pro Asp Thr Gly Gln Cys 
545                 550                 555                 560 


Arg Cys Arg Val Gly Phe Glu Gly Ala Thr Cys Asp Arg Cys Ala Pro 
                565                 570                 575     


Gly Tyr Phe His Phe Pro Leu Cys Gln Leu Cys Gly Cys Ser Pro Ala 
            580                 585                 590         


Gly Thr Leu Pro Glu Gly Cys Asp Glu Ala Gly Arg Cys Leu Cys Gln 
        595                 600                 605             


Pro Glu Phe Ala Gly Pro His Cys Asp Arg Cys Arg Pro Gly Tyr His 
    610                 615                 620                 


Gly Phe Pro Asn Cys Gln Ala Cys Thr Cys Asp Pro Arg Gly Ala Leu 
625                 630                 635                 640 


Asp Gln Leu Cys Gly Ala Gly Gly Leu Cys Arg Cys Arg Pro Gly Tyr 
                645                 650                 655     


Thr Gly Thr Ala Cys Gln Glu Cys Ser Pro Gly Phe His Gly Phe Pro 
            660                 665                 670         


Ser Cys Val Pro Cys His Cys Ser Ala Glu Gly Ser Leu His Ala Ala 
        675                 680                 685             


Cys Asp Pro Arg Ser Gly Gln Cys Ser Cys Arg Pro Arg Val Thr Gly 
    690                 695                 700                 


Leu Arg Cys Asp Thr Cys Val Pro Gly Ala Tyr Asn Phe Pro Tyr Cys 
705                 710                 715                 720 


Glu Ala Gly Ser Cys His Pro Ala Gly Leu Ala Pro Val Asp Pro Ala 
                725                 730                 735     


Leu Pro Glu Ala Gln Val Pro Cys Met Cys Arg Ala His Val Glu Gly 
            740                 745                 750         


Pro Ser Cys Asp Arg Cys Lys Pro Gly Phe Trp Gly Leu Ser Pro Ser 
        755                 760                 765             


Asn Pro Glu Gly Cys Thr Arg Cys Ser Cys Asp Leu Arg Gly Thr Leu 
    770                 775                 780                 


Gly Gly Val Ala Glu Cys Gln Pro Gly Thr Gly Gln Cys Phe Cys Lys 
785                 790                 795                 800 


Pro His Val Cys Gly Gln Ala Cys Ala Ser Cys Lys Asp Gly Phe Phe 
                805                 810                 815     


Gly Leu Asp Gln Ala Asp Tyr Phe Gly Cys Arg Ser Cys Arg Cys Asp 
            820                 825                 830         


Ile Gly Gly Ala Leu Gly Gln Ser Cys Glu Pro Arg Thr Gly Val Cys 
        835                 840                 845             


Arg Cys Arg Pro Asn Thr Gln Gly Pro Thr Cys Ser Glu Pro Ala Arg 
    850                 855                 860                 


Asp His Tyr Leu Pro Asp Leu His His Leu Arg Leu Glu Leu Glu Glu 
865                 870                 875                 880 


Ala Ala Thr Pro Glu Gly His Ala Val Arg Phe Gly Phe Asn Pro Leu 
                885                 890                 895     


Glu Phe Glu Asn Phe Ser Trp Arg Gly Tyr Ala Gln Met Ala Pro Val 
            900                 905                 910         


Gln Pro Arg Ile Val Ala Arg Leu Asn Leu Thr Ser Pro Asp Leu Phe 
        915                 920                 925             


Trp Leu Val Phe Arg Tyr Val Asn Arg Gly Ala Met Ser Val Ser Gly 
    930                 935                 940                 


Arg Val Ser Val Arg Glu Glu Gly Arg Ser Ala Thr Cys Ala Asn Cys 
945                 950                 955                 960 


Thr Ala Gln Ser Gln Pro Val Ala Phe Pro Pro Ser Thr Glu Pro Ala 
                965                 970                 975     


Phe Ile Thr Val Pro Gln Arg Gly Phe Gly Glu Pro Phe Val Leu Asn 
            980                 985                 990         


Pro Gly Thr Trp Ala Leu Arg Val  Glu Ala Glu Gly Val  Leu Leu Asp 
        995                 1000                 1005             


Tyr Val  Val Leu Leu Pro Ser  Ala Tyr Tyr Glu Ala  Ala Leu Leu 
    1010                 1015                 1020             


Gln Leu  Arg Val Thr Glu Ala  Cys Thr Tyr Arg Pro  Ser Ala Gln 
    1025                 1030                 1035             


Gln Ser  Gly Asp Asn Cys Leu  Leu Tyr Thr His Leu  Pro Leu Asp 
    1040                 1045                 1050             


Gly Phe  Pro Ser Ala Ala Gly  Leu Glu Ala Leu Cys  Arg Gln Asp 
    1055                 1060                 1065             


Asn Ser  Leu Pro Arg Pro Cys  Pro Thr Glu Gln Leu  Ser Pro Ser 
    1070                 1075                 1080             


His Pro  Pro Leu Ile Thr Cys  Thr Gly Ser Asp Val  Asp Val Gln 
    1085                 1090                 1095             


Leu Gln  Val Ala Val Pro Gln  Pro Gly Arg Tyr Ala  Leu Val Val 
    1100                 1105                 1110             


Glu Tyr  Ala Asn Glu Asp Ala  Arg Gln Glu Val Gly  Val Ala Val 
    1115                 1120                 1125             


His Thr  Pro Gln Arg Ala Pro  Gln Gln Gly Leu Leu  Ser Leu His 
    1130                 1135                 1140             


Pro Cys  Leu Tyr Ser Thr Leu  Cys Arg Gly Thr Ala  Arg Asp Thr 
    1145                 1150                 1155             


Gln Asp  His Leu Ala Val Phe  His Leu Asp Ser Glu  Ala Ser Val 
    1160                 1165                 1170             


Arg Leu  Thr Ala Glu Gln Ala  Arg Phe Phe Leu His  Gly Val Thr 
    1175                 1180                 1185             


Leu Val  Pro Ile Glu Glu Phe  Ser Pro Glu Phe Val  Glu Pro Arg 
    1190                 1195                 1200             


Val Ser  Cys Ile Ser Ser His  Gly Ala Phe Gly Pro  Asn Ser Ala 
    1205                 1210                 1215             


Ala Cys  Leu Pro Ser Arg Phe  Pro Lys Pro Pro Gln  Pro Ile Ile 
    1220                 1225                 1230             


Leu Arg  Asp Cys Gln Val Ile  Pro Leu Pro Pro Gly  Leu Pro Leu 
    1235                 1240                 1245             


Thr His  Ala Gln Asp Leu Thr  Pro Ala Met Ser Pro  Ala Gly Pro 
    1250                 1255                 1260             


Arg Pro  Arg Pro Pro Thr Ala  Val Asp Pro Asp Ala  Glu Pro Thr 
    1265                 1270                 1275             


Leu Leu  Arg Glu Pro Gln Ala  Thr Val Val Phe Thr  Thr His Val 
    1280                 1285                 1290             


Pro Thr  Leu Gly Arg Tyr Ala  Phe Leu Leu His Gly  Tyr Gln Pro 
    1295                 1300                 1305             


Ala His  Pro Thr Phe Pro Val  Glu Val Leu Ile Asn  Ala Gly Arg 
    1310                 1315                 1320             


Val Trp  Gln Gly His Ala Asn  Ala Ser Phe Cys Pro  His Gly Tyr 
    1325                 1330                 1335             


Gly Cys  Arg Thr Leu Val Val  Cys Glu Gly Gln Ala  Leu Leu Asp 
    1340                 1345                 1350             


Val Thr  His Ser Glu Leu Thr  Val Thr Val Arg Val  Pro Lys Gly 
    1355                 1360                 1365             


Arg Trp  Leu Trp Leu Asp Tyr  Val Leu Val Val Pro  Glu Asn Val 
    1370                 1375                 1380             


Tyr Ser  Phe Gly Tyr Leu Arg  Glu Glu Pro Leu Asp  Lys Ser Tyr 
    1385                 1390                 1395             


Asp Phe  Ile Ser His Cys Ala  Ala Gln Gly Tyr His  Ile Ser Pro 
    1400                 1405                 1410             


Ser Ser  Ser Ser Leu Phe Cys  Arg Asn Ala Ala Ala  Ser Leu Ser 
    1415                 1420                 1425             


Leu Phe  Tyr Asn Asn Gly Ala  Arg Pro Cys Gly Cys  His Glu Val 
    1430                 1435                 1440             


Gly Ala  Thr Gly Pro Thr Cys  Glu Pro Phe Gly Gly  Gln Cys Pro 
    1445                 1450                 1455             


Cys His  Ala His Val Ile Gly  Arg Asp Cys Ser Arg  Cys Ala Thr 
    1460                 1465                 1470             


Gly Tyr  Trp Gly Phe Pro Asn  Cys Arg Pro Cys Asp  Cys Gly Ala 
    1475                 1480                 1485             


Arg Leu  Cys Asp Glu Leu Thr  Gly Gln Cys Ile Cys  Pro Pro Arg 
    1490                 1495                 1500             


Thr Ile  Pro Pro Asp Cys Leu  Leu Cys Gln Pro Gln  Thr Phe Gly 
    1505                 1510                 1515             


Cys His  Pro Leu Val Gly Cys  Glu Glu Cys Asn Cys  Ser Gly Pro 
    1520                 1525                 1530             


Gly Ile  Gln Glu Leu Thr Asp  Pro Thr Cys Asp Thr  Asp Ser Gly 
    1535                 1540                 1545             


Gln Cys  Lys Cys Arg Pro Asn  Val Thr Gly Arg Arg  Cys Asp Thr 
    1550                 1555                 1560             


Cys Ser  Pro Gly Phe His Gly  Tyr Pro Arg Cys Arg  Pro Cys Asp 
    1565                 1570                 1575             


Cys His  Glu Ala Gly Thr Ala  Pro Gly Val Cys Asp  Pro Leu Thr 
    1580                 1585                 1590             


Gly Gln  Cys Tyr Cys Lys Glu  Asn Val Gln Gly Pro  Lys Cys Asp 
    1595                 1600                 1605             


Gln Cys  Ser Leu Gly Thr Phe  Ser Leu Asp Ala Ala  Asn Pro Lys 
    1610                 1615                 1620             


Gly Cys  Thr Arg Cys Phe Cys  Phe Gly Ala Thr Glu  Arg Cys Arg 
    1625                 1630                 1635             


Ser Ser  Ser Tyr Thr Arg Gln  Glu Phe Val Asp Met  Glu Gly Trp 
    1640                 1645                 1650             


Val Leu  Leu Ser Thr Asp Arg  Gln Val Val Pro His  Glu Arg Gln 
    1655                 1660                 1665             


Pro Gly  Thr Glu Met Leu Arg  Ala Asp Leu Arg His  Val Pro Glu 
    1670                 1675                 1680             


Ala Val  Pro Glu Ala Phe Pro  Glu Leu Tyr Trp Gln  Ala Pro Pro 
    1685                 1690                 1695             


Ser Tyr  Leu Gly Asp Arg Val  Ser Ser Tyr Gly Gly  Thr Leu Arg 
    1700                 1705                 1710             


Tyr Glu  Leu His Ser Glu Thr  Gln Arg Gly Asp Val  Phe Val Pro 
    1715                 1720                 1725             


Met Glu  Ser Arg Pro Asp Val  Val Leu Gln Gly Asn  Gln Met Ser 
    1730                 1735                 1740             


Ile Thr  Phe Leu Glu Pro Ala  Tyr Pro Thr Pro Gly  His Val His 
    1745                 1750                 1755             


Arg Gly  Gln Leu Gln Leu Val  Glu Gly Asn Phe Arg  His Thr Glu 
    1760                 1765                 1770             


Thr Arg  Asn Thr Val Ser Arg  Glu Glu Leu Met Met  Val Leu Ala 
    1775                 1780                 1785             


Ser Leu  Glu Gln Leu Gln Ile  Arg Ala Leu Phe Ser  Gln Ile Ser 
    1790                 1795                 1800             


Ser Ala  Val Phe Leu Arg Arg  Val Ala Leu Glu Val  Ala Ser Pro 
    1805                 1810                 1815             


Ala Gly  Gln Gly Ala Leu Ala  Ser Asn Val Glu Leu  Cys Leu Cys 
    1820                 1825                 1830             


Pro Ala  Ser Tyr Arg Gly Asp  Ser Cys Gln Glu Cys  Ala Pro Gly 
    1835                 1840                 1845             


Phe Tyr  Arg Asp Val Lys Gly  Leu Phe Leu Gly Arg  Cys Val Pro 
    1850                 1855                 1860             


Cys Gln  Cys His Gly His Ser  Asp Arg Cys Leu Pro  Gly Ser Gly 
    1865                 1870                 1875             


Val Cys  Val Asp Cys Gln His  Asn Thr Glu Gly Ala  His Cys Glu 
    1880                 1885                 1890             


Arg Cys  Gln Ala Gly Phe Val  Ser Ser Arg Asp Asp  Pro Ser Ala 
    1895                 1900                 1905             


Pro Cys  Val Ser Cys Pro Cys  Pro Leu Ser Val Pro  Ser Asn Asn 
    1910                 1915                 1920             


Phe Ala  Glu Gly Cys Val Leu  Arg Gly Gly Arg Thr  Gln Cys Leu 
    1925                 1930                 1935             


Cys Lys  Pro Gly Tyr Ala Gly  Ala Ser Cys Glu Arg  Cys Ala Pro 
    1940                 1945                 1950             


Gly Phe  Phe Gly Asn Pro Leu  Val Leu Gly Ser Ser  Cys Gln Pro 
    1955                 1960                 1965             


Cys Asp  Cys Ser Gly Asn Gly  Asp Pro Asn Leu Leu  Phe Ser Asp 
    1970                 1975                 1980             


Cys Asp  Pro Leu Thr Gly Ala  Cys Arg Gly Cys Leu  Arg His Thr 
    1985                 1990                 1995             


Thr Gly  Pro Arg Cys Glu Ile  Cys Ala Pro Gly Phe  Tyr Gly Asn 
    2000                 2005                 2010             


Ala Leu  Leu Pro Gly Asn Cys  Thr Arg Cys Asp Cys  Thr Pro Cys 
    2015                 2020                 2025             


Gly Thr  Glu Ala Cys Asp Pro  His Ser Gly His Cys  Leu Cys Lys 
    2030                 2035                 2040             


Ala Gly  Val Thr Gly Arg Arg  Cys Asp Arg Cys Gln  Glu Gly His 
    2045                 2050                 2055             


Phe Gly  Phe Asp Gly Cys Gly  Gly Cys Arg Pro Cys  Ala Cys Gly 
    2060                 2065                 2070             


Pro Ala  Ala Glu Gly Ser Glu  Cys His Pro Gln Ser  Gly Gln Cys 
    2075                 2080                 2085             


His Cys  Arg Pro Gly Thr Met  Gly Pro Gln Cys Arg  Glu Cys Ala 
    2090                 2095                 2100             


Pro Gly  Tyr Trp Gly Leu Pro  Glu Gln Gly Cys Arg  Arg Cys Gln 
    2105                 2110                 2115             


Cys Pro  Gly Gly Arg Cys Asp  Pro His Thr Gly Arg  Cys Asn Cys 
    2120                 2125                 2130             


Pro Pro  Gly Leu Ser Gly Glu  Arg Cys Asp Thr Cys  Ser Gln Gln 
    2135                 2140                 2145             


His Gln  Val Pro Val Pro Gly  Gly Pro Val Gly His  Ser Ile His 
    2150                 2155                 2160             


Cys Glu  Val Cys Asp His Cys  Val Val Leu Leu Leu  Asp Asp Leu 
    2165                 2170                 2175             


Glu Arg  Ala Gly Ala Leu Leu  Pro Ala Ile His Glu  Gln Leu Arg 
    2180                 2185                 2190             


Gly Ile  Asn Ala Ser Ser Met  Ala Trp Ala Arg Leu  His Arg Leu 
    2195                 2200                 2205             


Asn Ala  Ser Ile Ala Asp Leu  Gln Ser Gln Leu Arg  Ser Pro Leu 
    2210                 2215                 2220             


Gly Pro  Arg His Glu Thr Ala  Gln Gln Leu Glu Val  Leu Glu Gln 
    2225                 2230                 2235             


Gln Ser  Thr Ser Leu Gly Gln  Asp Ala Arg Arg Leu  Gly Gly Gln 
    2240                 2245                 2250             


Ala Val  Gly Thr Arg Asp Gln  Ala Ser Gln Leu Leu  Ala Gly Thr 
    2255                 2260                 2265             


Glu Ala  Thr Leu Gly His Ala  Lys Thr Leu Leu Ala  Ala Ile Arg 
    2270                 2275                 2280             


Ala Val  Asp Arg Thr Leu Ser  Glu Leu Met Ser Gln  Thr Gly His 
    2285                 2290                 2295             


Leu Gly  Leu Ala Asn Ala Ser  Ala Pro Ser Gly Glu  Gln Leu Leu 
    2300                 2305                 2310             


Arg Thr  Leu Ala Glu Val Glu  Arg Leu Leu Trp Glu  Met Arg Ala 
    2315                 2320                 2325             


Arg Asp  Leu Gly Ala Pro Gln  Ala Ala Ala Glu Ala  Glu Leu Ala 
    2330                 2335                 2340             


Ala Ala  Gln Arg Leu Leu Ala  Arg Val Gln Glu Gln  Leu Ser Ser 
    2345                 2350                 2355             


Leu Trp  Glu Glu Asn Gln Ala  Leu Ala Thr Gln Thr  Arg Asp Arg 
    2360                 2365                 2370             


Leu Ala  Gln His Glu Ala Gly  Leu Met Asp Leu Arg  Glu Ala Leu 
    2375                 2380                 2385             


Asn Arg  Ala Val Asp Ala Thr  Arg Glu Ala Gln Glu  Leu Asn Ser 
    2390                 2395                 2400             


Arg Asn  Gln Glu Arg Leu Glu  Glu Ala Leu Gln Arg  Lys Gln Glu 
    2405                 2410                 2415             


Leu Ser  Arg Asp Asn Ala Thr  Leu Gln Ala Thr Leu  His Ala Ala 
    2420                 2425                 2430             


Arg Asp  Thr Leu Ala Ser Val  Phe Arg Leu Leu His  Ser Leu Asp 
    2435                 2440                 2445             


Gln Ala  Lys Glu Glu Leu Glu  Arg Leu Ala Ala Ser  Leu Asp Gly 
    2450                 2455                 2460             


Ala Arg  Thr Pro Leu Leu Gln  Arg Met Gln Thr Phe  Ser Pro Ala 
    2465                 2470                 2475             


Gly Ser  Lys Leu Arg Leu Val  Glu Ala Ala Glu Ala  His Ala Gln 
    2480                 2485                 2490             


Gln Leu  Gly Gln Leu Ala Leu  Asn Leu Ser Ser Ile  Ile Leu Asp 
    2495                 2500                 2505             


Val Asn  Gln Asp Arg Leu Thr  Gln Arg Ala Ile Glu  Ala Ser Asn 
    2510                 2515                 2520             


Ala Tyr  Ser Arg Ile Leu Gln  Ala Val Gln Ala Ala  Glu Asp Ala 
    2525                 2530                 2535             


Ala Gly  Gln Ala Leu Gln Gln  Ala Asp His Thr Trp  Ala Thr Val 
    2540                 2545                 2550             


Val Arg  Gln Gly Leu Val Asp  Arg Ala Gln Gln Leu  Leu Ala Asn 
    2555                 2560                 2565             


Ser Thr  Ala Leu Glu Glu Ala  Met Leu Gln Glu Gln  Gln Arg Leu 
    2570                 2575                 2580             


Gly Leu  Val Trp Ala Ala Leu  Gln Gly Ala Arg Thr  Gln Leu Arg 
    2585                 2590                 2595             


Asp Val  Arg Ala Lys Lys Asp  Gln Leu Glu Ala His  Ile Gln Ala 
    2600                 2605                 2610             


Ala Gln  Ala Met Leu Ala Met  Asp Thr Asp Glu Thr  Ser Lys Lys 
    2615                 2620                 2625             


Ile Ala  His Ala Lys Ala Val  Ala Ala Glu Ala Gln  Asp Thr Ala 
    2630                 2635                 2640             


Thr Arg  Val Gln Ser Gln Leu  Gln Ala Met Gln Glu  Asn Val Glu 
    2645                 2650                 2655             


Arg Trp  Gln Gly Gln Tyr Glu  Gly Leu Arg Gly Gln  Asp Leu Gly 
    2660                 2665                 2670             


Gln Ala  Val Leu Asp Ala Gly  His Ser Val Ser Thr  Leu Glu Lys 
    2675                 2680                 2685             


Thr Leu  Pro Gln Leu Leu Ala  Lys Leu Ser Ile Leu  Glu Asn Arg 
    2690                 2695                 2700             


Gly Val  His Asn Ala Ser Leu  Ala Leu Ser Ala Ser  Ile Gly Arg 
    2705                 2710                 2715             


Val Arg  Glu Leu Ile Ala Gln  Ala Arg Gly Ala Ala  Ser Lys Val 
    2720                 2725                 2730             


Lys Val  Pro Met Lys Phe Asn  Gly Arg Ser Gly Val  Gln Leu Arg 
    2735                 2740                 2745             


Thr Pro  Arg Asp Leu Ala Asp  Leu Ala Ala Tyr Thr  Ala Leu Lys 
    2750                 2755                 2760             


Phe Tyr  Leu Gln Gly Pro Glu  Pro Glu Pro Gly Gln  Gly Thr Glu 
    2765                 2770                 2775             


Asp Arg  Phe Val Met Tyr Met  Gly Ser Arg Gln Ala  Thr Gly Asp 
    2780                 2785                 2790             


Tyr Met  Gly Val Ser Leu Arg  Asp Lys Lys Val His  Trp Val Tyr 
    2795                 2800                 2805             


Gln Leu  Gly Glu Ala Gly Pro  Ala Val Leu Ser Ile  Asp Glu Asp 
    2810                 2815                 2820             


Ile Gly  Glu Gln Phe Ala Ala  Val Ser Leu Asp Arg  Thr Leu Gln 
    2825                 2830                 2835             


Phe Gly  His Met Ser Val Thr  Val Glu Arg Gln Met  Ile Gln Glu 
    2840                 2845                 2850             


Thr Lys  Gly Asp Thr Val Ala  Pro Gly Ala Glu Gly  Leu Leu Asn 
    2855                 2860                 2865             


Leu Arg  Pro Asp Asp Phe Val  Phe Tyr Val Gly Gly  Tyr Pro Ser 
    2870                 2875                 2880             


Thr Phe  Thr Pro Pro Pro Leu  Leu Arg Phe Pro Gly  Tyr Arg Gly 
    2885                 2890                 2895             


Cys Ile  Glu Met Asp Thr Leu  Asn Glu Glu Val Val  Ser Leu Tyr 
    2900                 2905                 2910             


Asn Phe  Glu Arg Thr Phe Gln  Leu Asp Thr Ala Val  Asp Arg Pro 
    2915                 2920                 2925             


Cys Ala  Arg Ser Lys Ser Thr  Gly Asp Pro Trp Leu  Thr Asp Gly 
    2930                 2935                 2940             


Ser Tyr  Leu Asp Gly Thr Gly  Phe Ala Arg Ile Ser  Phe Asp Ser 
    2945                 2950                 2955             


Gln Ile  Ser Thr Thr Lys Arg  Phe Glu Gln Glu Leu  Arg Leu Val 
    2960                 2965                 2970             


Ser Tyr  Ser Gly Val Leu Phe  Phe Leu Lys Gln Gln  Ser Gln Phe 
    2975                 2980                 2985             


Leu Cys  Leu Ala Val Gln Glu  Gly Ser Leu Val Leu  Leu Tyr Asp 
    2990                 2995                 3000             


Phe Gly  Ala Gly Leu Lys Lys  Ala Val Pro Leu Gln  Pro Pro Pro 
    3005                 3010                 3015             


Pro Leu  Thr Ser Ala Ser Lys  Ala Ile Gln Val Phe  Leu Leu Gly 
    3020                 3025                 3030             


Gly Ser  Arg Lys Arg Val Leu  Val Arg Val Glu Arg  Ala Thr Val 
    3035                 3040                 3045             


Tyr Ser  Val Glu Gln Asp Asn  Asp Leu Glu Leu Ala  Asp Ala Tyr 
    3050                 3055                 3060             


Tyr Leu  Gly Gly Val Pro Pro  Asp Gln Leu Pro Pro  Ser Leu Arg 
    3065                 3070                 3075             


Arg Leu  Phe Pro Thr Gly Gly  Ser Val Arg Gly Cys  Val Lys Gly 
    3080                 3085                 3090             


Ile Lys  Ala Leu Gly Lys Tyr  Val Asp Leu Lys Arg  Leu Asn Thr 
    3095                 3100                 3105             


Thr Gly  Val Ser Ala Gly Cys  Thr Ala Asp Leu Leu  Val Gly Arg 
    3110                 3115                 3120             


Ala Met  Thr Phe His Gly His  Gly Phe Leu Arg Leu  Ala Leu Ser 
    3125                 3130                 3135             


Asn Val  Ala Pro Leu Thr Gly  Asn Val Tyr Ser Gly  Phe Gly Phe 
    3140                 3145                 3150             


His Ser  Ala Gln Asp Ser Ala  Leu Leu Tyr Tyr Arg  Ala Ser Pro 
    3155                 3160                 3165             


Asp Gly  Leu Cys Gln Val Ser  Leu Gln Gln Gly Arg  Val Ser Leu 
    3170                 3175                 3180             


Gln Leu  Leu Arg Thr Glu Val  Lys Thr Gln Ala Gly  Phe Ala Asp 
    3185                 3190                 3195             


Gly Ala  Pro His Tyr Val Ala  Phe Tyr Ser Asn Ala  Thr Gly Val 
    3200                 3205                 3210             


Trp Leu  Tyr Val Asp Asp Gln  Leu Gln Gln Met Lys  Pro His Arg 
    3215                 3220                 3225             


Gly Pro  Pro Pro Glu Leu Gln  Pro Gln Pro Glu Gly  Pro Pro Arg 
    3230                 3235                 3240             


Leu Leu  Leu Gly Gly Leu Pro  Glu Ser Gly Thr Ile  Tyr Asn Phe 
    3245                 3250                 3255             


Ser Gly  Cys Ile Ser Asn Val  Phe Val Gln Arg Leu  Leu Gly Pro 
    3260                 3265                 3270             


Gln Arg  Val Phe Asp Leu Gln  Gln Asn Leu Gly Ser  Val Asn Val 
    3275                 3280                 3285             


Ser Thr  Gly Cys Ala Pro Ala  Leu Gln Ala Gln Thr  Pro Gly Leu 
    3290                 3295                 3300             


Gly Pro  Arg Gly Leu Gln Ala  Thr Ala Arg Lys Ala  Ser Arg Arg 
    3305                 3310                 3315             


Ser Arg  Gln Pro Ala Arg His  Pro Ala Cys Met Leu  Pro Pro His 
    3320                 3325                 3330             


Leu Arg  Thr Thr Arg Asp Ser  Tyr Gln Phe Gly Gly  Ser Leu Ser 
    3335                 3340                 3345             


Ser His  Leu Glu Phe Val Gly  Ile Leu Ala Arg His  Arg Asn Trp 
    3350                 3355                 3360             


Pro Ser  Leu Ser Met His Val  Leu Pro Arg Ser Ser  Arg Gly Leu 
    3365                 3370                 3375             


Leu Leu  Phe Thr Ala Arg Leu  Arg Pro Gly Ser Pro  Ser Leu Ala 
    3380                 3385                 3390             


Leu Phe  Leu Ser Asn Gly His  Phe Val Ala Gln Met  Glu Gly Leu 
    3395                 3400                 3405             


Gly Thr  Arg Leu Arg Ala Gln  Ser Arg Gln Arg Ser  Arg Pro Gly 
    3410                 3415                 3420             


Arg Trp  His Lys Val Ser Val  Arg Trp Glu Lys Asn  Arg Ile Leu 
    3425                 3430                 3435             


Leu Val  Thr Asp Gly Ala Arg  Ala Trp Ser Gln Glu  Gly Pro His 
    3440                 3445                 3450             


Arg Gln  His Gln Gly Ala Glu  His Pro Gln Pro His  Thr Leu Phe 
    3455                 3460                 3465             


Val Gly  Gly Leu Pro Ala Ser  Ser His Ser Ser Lys  Leu Pro Val 
    3470                 3475                 3480             


Thr Val  Gly Phe Ser Gly Cys  Val Lys Arg Leu Arg  Leu His Gly 
    3485                 3490                 3495             


Arg Pro  Leu Gly Ala Pro Thr  Arg Met Ala Gly Val  Thr Pro Cys 
    3500                 3505                 3510             


Ile Leu  Gly Pro Leu Glu Ala  Gly Leu Phe Phe Pro  Gly Ser Gly 
    3515                 3520                 3525             


Gly Val  Ile Thr Leu Asp Leu  Pro Gly Ala Thr Leu  Pro Asp Val 
    3530                 3535                 3540             


Gly Leu  Glu Leu Glu Val Arg  Pro Leu Ala Val Thr  Gly Leu Ile 
    3545                 3550                 3555             


Phe His  Leu Gly Gln Ala Arg  Thr Pro Pro Tyr Leu  Gln Leu Gln 
    3560                 3565                 3570             


Val Thr  Glu Lys Gln Val Leu  Leu Arg Ala Asp Asp  Gly Ala Gly 
    3575                 3580                 3585             


Glu Phe  Ser Thr Ser Val Thr  Arg Pro Ser Val Leu  Cys Asp Gly 
    3590                 3595                 3600             


Gln Trp  His Arg Leu Ala Val  Met Lys Ser Gly Asn  Val Leu Arg 
    3605                 3610                 3615             


Leu Glu  Val Asp Ala Gln Ser  Asn His Thr Val Gly  Pro Leu Leu 
    3620                 3625                 3630             


Ala Ala  Ala Ala Gly Ala Pro  Ala Pro Leu Tyr Leu  Gly Gly Leu 
    3635                 3640                 3645             


Pro Glu  Pro Met Ala Val Gln  Pro Trp Pro Pro Ala  Tyr Cys Gly 
    3650                 3655                 3660             


Cys Met  Arg Arg Leu Ala Val  Asn Arg Ser Pro Val  Ala Met Thr 
    3665                 3670                 3675             


Arg Ser  Val Glu Val His Gly  Ala Val Gly Ala Ser  Gly Cys Pro 
    3680                 3685                 3690             


Ala Ala  
    3695 


<210>  7674
<211>  241
<212>  PRT
<213>  Homo Sapiens

<400>  7674

Arg Leu Arg Phe Leu Arg Thr Asn Thr Leu Leu Gly His Leu Met Gly 
1               5                   10                  15      


Lys Ala Leu Arg Asp Pro Thr Val Thr Arg Arg Tyr Tyr Tyr Ser Ile 
            20                  25                  30          


Lys Asp Ile Ser Ile Gly Gly Arg Cys Val Cys His Gly His Ala Asp 
        35                  40                  45              


Ala Cys Asp Ala Lys Asp Pro Thr Asp Pro Phe Ser Ser Pro Asn Leu 
    50                  55                  60                  


Ser Gly His Asn Arg Gln Leu Pro Cys Cys Pro Ser Pro Asp Leu His 
65                  70                  75                  80  


Ser Ser Gln Ala Gly Thr Lys Ala Gln Asp Gly Asp Gly Arg Val Gly 
                85                  90                  95      


Ala Ala Asn Thr Pro His Leu Leu Cys Pro Val Cys Leu Leu Ser Gly 
            100                 105                 110         


Ala Ala Glu Gly Thr Ala Glu His Pro Pro Pro Gly Ser Pro Ser Gln 
        115                 120                 125             


Asp Gly Gln Gln Pro Trp Cys Trp His Arg His Ile Pro Gly Pro His 
    130                 135                 140                 


Pro Glu Ser Ser Val Arg Leu Gln Cys Thr Cys Gln His Asn Thr Cys 
145                 150                 155                 160 


Gly Gly Thr Cys Asp Arg Cys Cys Pro Gly Phe Asn Gln Gln Pro Trp 
                165                 170                 175     


Lys Pro Ala Thr Ala Asn Ser Ala Asn Glu Cys Gln Ser Cys Asn Cys 
            180                 185                 190         


Tyr Gly His Ala Thr Asp Cys Tyr Tyr Asp Pro Glu Val Asp Arg Arg 
        195                 200                 205             


Arg Ala Ser Gln Ser Leu Asp Gly Thr Tyr Gln Gly Gly Gly Val Cys 
    210                 215                 220                 


Ile Asp Cys Gln His His Thr Thr Gly Val Asn Cys Glu Arg Cys Leu 
225                 230                 235                 240 


Pro 
    


<210>  7675
<211>  1810
<212>  PRT
<213>  Homo Sapiens

<400>  7675

Met Asp Cys Pro Leu Ser Ala Pro Thr Pro Pro Pro Pro Leu Val Arg 
1               5                   10                  15      


Phe Phe Arg Ala Pro Leu Pro Ala Cys Val Pro Pro Thr Leu Leu Pro 
            20                  25                  30          


Val Leu Pro Ala Ala Leu Cys Arg Ala Arg Val Arg Ala Gln Glu Pro 
        35                  40                  45              


Glu Phe Ser Tyr Gly Cys Ala Glu Gly Ser Cys Tyr Pro Ala Thr Gly 
    50                  55                  60                  


Asp Leu Leu Ile Gly Arg Ala Gln Lys Leu Ser Val Thr Ser Thr Cys 
65                  70                  75                  80  


Gly Leu His Lys Pro Glu Pro Tyr Cys Ile Val Ser His Leu Gln Glu 
                85                  90                  95      


Asp Lys Lys Cys Phe Ile Cys Asn Ser Gln Asp Pro Tyr His Glu Thr 
            100                 105                 110         


Leu Asn Pro Asp Ser His Leu Ile Glu Asn Val Val Thr Thr Phe Ala 
        115                 120                 125             


Pro Asn Arg Leu Lys Ile Trp Trp Gln Ser Glu Asn Gly Val Glu Asn 
    130                 135                 140                 


Val Thr Ile Gln Leu Asp Leu Glu Ala Glu Phe His Phe Thr His Leu 
145                 150                 155                 160 


Ile Met Thr Phe Lys Thr Phe Arg Pro Ala Ala Met Leu Ile Glu Arg 
                165                 170                 175     


Ser Ser Asp Phe Gly Lys Thr Trp Gly Val Tyr Arg Tyr Phe Ala Tyr 
            180                 185                 190         


Asp Cys Glu Ala Ser Phe Pro Gly Ile Ser Thr Gly Pro Met Lys Lys 
        195                 200                 205             


Val Asp Asp Ile Ile Cys Asp Ser Arg Tyr Ser Asp Ile Glu Pro Ser 
    210                 215                 220                 


Thr Glu Gly Glu Val Ile Phe Arg Ala Leu Asp Pro Ala Phe Lys Ile 
225                 230                 235                 240 


Glu Asp Pro Tyr Ser Pro Arg Ile Gln Asn Leu Leu Lys Ile Thr Asn 
                245                 250                 255     


Leu Arg Ile Lys Phe Val Lys Leu His Thr Leu Gly Asp Asn Leu Leu 
            260                 265                 270         


Asp Ser Arg Met Glu Ile Arg Glu Lys Tyr Tyr Tyr Ala Val Tyr Asp 
        275                 280                 285             


Met Val Val Arg Gly Asn Cys Phe Cys Tyr Gly His Ala Ser Glu Cys 
    290                 295                 300                 


Ala Pro Val Asp Gly Phe Asn Glu Glu Val Glu Gly Met Val His Gly 
305                 310                 315                 320 


His Cys Met Cys Arg His Asn Thr Lys Gly Leu Asn Cys Glu Leu Cys 
                325                 330                 335     


Met Asp Phe Tyr His Asp Leu Pro Trp Arg Pro Ala Glu Gly Arg Asn 
            340                 345                 350         


Ser Asn Ala Cys Lys Lys Cys Asn Cys Asn Glu His Ser Ile Ser Cys 
        355                 360                 365             


His Phe Asp Met Ala Val Tyr Leu Ala Thr Gly Asn Val Ser Gly Gly 
    370                 375                 380                 


Val Cys Asp Asp Cys Gln His Asn Thr Met Gly Arg Asn Cys Glu Gln 
385                 390                 395                 400 


Cys Lys Pro Phe Tyr Tyr Gln His Pro Glu Arg Asp Ile Arg Asp Pro 
                405                 410                 415     


Asn Phe Cys Glu Arg Cys Thr Cys Asp Pro Ala Gly Ser Gln Asn Glu 
            420                 425                 430         


Gly Ile Cys Asp Ser Tyr Thr Asp Phe Ser Thr Gly Leu Ile Ala Gly 
        435                 440                 445             


Gln Cys Arg Cys Lys Leu Asn Val Glu Gly Glu His Cys Asp Val Cys 
    450                 455                 460                 


Lys Glu Gly Phe Tyr Asp Leu Ser Ser Glu Asp Pro Phe Gly Cys Lys 
465                 470                 475                 480 


Ser Cys Ala Cys Asn Pro Leu Gly Thr Ile Pro Gly Gly Asn Pro Cys 
                485                 490                 495     


Asp Ser Glu Thr Gly His Cys Tyr Cys Lys Arg Leu Val Thr Gly Gln 
            500                 505                 510         


His Cys Asp Gln Cys Leu Pro Glu His Trp Gly Leu Ser Asn Asp Leu 
        515                 520                 525             


Asp Gly Cys Arg Pro Cys Asp Cys Asp Leu Gly Gly Ala Leu Asn Asn 
    530                 535                 540                 


Ser Cys Phe Ala Glu Ser Gly Gln Cys Ser Cys Arg Pro His Met Ile 
545                 550                 555                 560 


Gly Arg Gln Cys Asn Glu Val Glu Pro Gly Tyr Tyr Phe Ala Thr Leu 
                565                 570                 575     


Asp His Tyr Leu Tyr Glu Ala Glu Glu Ala Asn Leu Gly Pro Gly Val 
            580                 585                 590         


Ser Ile Val Glu Arg Gln Tyr Ile Gln Asp Arg Ile Pro Ser Trp Thr 
        595                 600                 605             


Gly Ala Gly Phe Val Arg Val Pro Glu Gly Ala Tyr Leu Glu Phe Phe 
    610                 615                 620                 


Ile Asp Asn Ile Pro Tyr Ser Met Glu Tyr Asp Ile Leu Ile Arg Tyr 
625                 630                 635                 640 


Glu Pro Gln Leu Pro Asp His Trp Glu Lys Ala Val Ile Thr Val Gln 
                645                 650                 655     


Arg Pro Gly Arg Ile Pro Thr Ser Ser Arg Cys Gly Asn Thr Ile Pro 
            660                 665                 670         


Asp Asp Asp Asn Gln Val Val Ser Leu Ser Pro Gly Ser Arg Tyr Val 
        675                 680                 685             


Val Leu Pro Arg Pro Val Cys Phe Glu Lys Gly Thr Asn Tyr Thr Val 
    690                 695                 700                 


Arg Leu Glu Leu Pro Gln Tyr Thr Ser Ser Asp Ser Asp Val Glu Ser 
705                 710                 715                 720 


Pro Tyr Thr Leu Ile Asp Ser Leu Val Leu Met Pro Tyr Cys Lys Ser 
                725                 730                 735     


Leu Asp Ile Phe Thr Val Gly Gly Ser Gly Asp Gly Val Val Thr Asn 
            740                 745                 750         


Ser Ala Trp Glu Thr Phe Gln Arg Tyr Arg Cys Leu Glu Asn Ser Arg 
        755                 760                 765             


Ser Val Val Lys Thr Pro Met Thr Asp Val Cys Arg Asn Ile Ile Phe 
    770                 775                 780                 


Ser Ile Ser Ala Leu Leu His Gln Thr Gly Leu Ala Cys Glu Cys Asp 
785                 790                 795                 800 


Pro Gln Gly Ser Leu Ser Ser Val Cys Asp Pro Asn Gly Gly Gln Cys 
                805                 810                 815     


Gln Cys Arg Pro Asn Val Val Gly Arg Thr Cys Asn Arg Cys Ala Pro 
            820                 825                 830         


Gly Thr Phe Gly Phe Gly Pro Ser Gly Cys Lys Pro Cys Glu Cys His 
        835                 840                 845             


Leu Gln Gly Ser Val Asn Ala Phe Cys Asn Pro Val Thr Gly Gln Cys 
    850                 855                 860                 


His Cys Phe Gln Gly Val Tyr Ala Arg Gln Cys Asp Arg Cys Leu Pro 
865                 870                 875                 880 


Gly His Trp Gly Phe Pro Ser Cys Gln Pro Cys Gln Cys Asn Gly His 
                885                 890                 895     


Ala Asp Asp Cys Asp Pro Val Thr Gly Glu Cys Leu Asn Cys Gln Asp 
            900                 905                 910         


Tyr Thr Met Gly His Asn Cys Glu Arg Cys Leu Ala Gly Tyr Tyr Gly 
        915                 920                 925             


Asp Pro Ile Ile Gly Ser Gly Asp His Cys Arg Pro Cys Pro Cys Pro 
    930                 935                 940                 


Asp Gly Pro Asp Ser Gly Arg Gln Phe Ala Arg Ser Cys Tyr Gln Asp 
945                 950                 955                 960 


Pro Val Thr Leu Gln Leu Ala Cys Val Cys Asp Pro Gly Tyr Ile Gly 
                965                 970                 975     


Ser Arg Cys Asp Asp Cys Ala Ser Gly Tyr Phe Gly Asn Pro Ser Glu 
            980                 985                 990         


Val Gly Gly Ser Cys Gln Pro Cys  Gln Cys His Asn Asn  Ile Asp Thr 
        995                 1000                 1005             


Thr Asp  Pro Glu Ala Cys Asp  Lys Glu Thr Gly Arg  Cys Leu Lys 
    1010                 1015                 1020             


Cys Leu  Tyr His Thr Glu Gly  Glu His Cys Gln Phe  Cys Arg Phe 
    1025                 1030                 1035             


Gly Tyr  Tyr Gly Asp Ala Leu  Gln Gln Asp Cys Arg  Lys Cys Val 
    1040                 1045                 1050             


Cys Asn  Tyr Leu Gly Thr Val  Gln Glu His Cys Asn  Gly Ser Asp 
    1055                 1060                 1065             


Cys Gln  Cys Asp Lys Ala Thr  Gly Gln Cys Leu Cys  Leu Pro Asn 
    1070                 1075                 1080             


Val Ile  Gly Gln Asn Cys Asp  Arg Cys Ala Pro Asn  Thr Trp Gln 
    1085                 1090                 1095             


Leu Ala  Ser Gly Thr Gly Cys  Asp Pro Cys Asn Cys  Asn Ala Ala 
    1100                 1105                 1110             


His Ser  Phe Gly Pro Ser Cys  Asn Glu Phe Thr Gly  Gln Cys Gln 
    1115                 1120                 1125             


Cys Met  Pro Gly Phe Gly Gly  Arg Thr Cys Ser Glu  Cys Gln Glu 
    1130                 1135                 1140             


Leu Phe  Trp Gly Asp Pro Asp  Val Glu Cys Arg Ala  Cys Asp Cys 
    1145                 1150                 1155             


Asp Pro  Arg Gly Ile Glu Thr  Pro Gln Cys Asp Gln  Ser Thr Gly 
    1160                 1165                 1170             


Gln Cys  Val Cys Val Glu Gly  Val Glu Gly Pro Arg  Cys Asp Lys 
    1175                 1180                 1185             


Cys Thr  Arg Gly Tyr Ser Gly  Val Phe Pro Asp Cys  Thr Pro Cys 
    1190                 1195                 1200             


His Gln  Cys Phe Ala Leu Trp  Asp Val Ile Ile Ala  Glu Leu Thr 
    1205                 1210                 1215             


Asn Arg  Thr His Arg Phe Leu  Glu Lys Ala Lys Ala  Leu Lys Ile 
    1220                 1225                 1230             


Ser Gly  Val Ile Gly Pro Tyr  Arg Glu Thr Val Asp  Ser Val Glu 
    1235                 1240                 1245             


Arg Lys  Val Ser Glu Ile Lys  Asp Ile Leu Ala Gln  Ser Pro Ala 
    1250                 1255                 1260             


Ala Glu  Pro Leu Lys Asn Ile  Gly Asn Leu Phe Glu  Glu Ala Glu 
    1265                 1270                 1275             


Lys Leu  Ile Lys Asp Val Thr  Glu Met Met Ala Gln  Val Glu Val 
    1280                 1285                 1290             


Lys Leu  Ser Asp Thr Thr Ser  Gln Ser Asn Ser Thr  Ala Lys Glu 
    1295                 1300                 1305             


Leu Asp  Ser Leu Gln Thr Glu  Ala Glu Ser Leu Asp  Asn Thr Val 
    1310                 1315                 1320             


Lys Glu  Leu Ala Glu Gln Leu  Glu Phe Ile Lys Asn  Ser Asp Ile 
    1325                 1330                 1335             


Arg Gly  Ala Leu Asp Ser Ile  Thr Lys Tyr Phe Gln  Met Ser Leu 
    1340                 1345                 1350             


Glu Ala  Glu Glu Arg Val Asn  Ala Ser Thr Thr Glu  Pro Asn Ser 
    1355                 1360                 1365             


Thr Val  Glu Gln Ser Ala Leu  Met Arg Asp Arg Val  Glu Asp Val 
    1370                 1375                 1380             


Met Met  Glu Arg Glu Ser Gln  Phe Lys Glu Lys Gln  Glu Glu Gln 
    1385                 1390                 1395             


Ala Arg  Leu Leu Asp Glu Leu  Ala Gly Lys Leu Gln  Ser Leu Asp 
    1400                 1405                 1410             


Leu Ser  Ala Ala Ala Glu Met  Thr Cys Gly Thr Pro  Pro Gly Ala 
    1415                 1420                 1425             


Ser Cys  Ser Glu Thr Glu Cys  Gly Gly Pro Asn Cys  Arg Thr Asp 
    1430                 1435                 1440             


Glu Gly  Glu Arg Lys Cys Gly  Gly Pro Gly Cys Gly  Gly Leu Val 
    1445                 1450                 1455             


Thr Val  Ala His Asn Ala Trp  Gln Lys Ala Met Asp  Leu Asp Gln 
    1460                 1465                 1470             


Asp Val  Leu Ser Ala Leu Ala  Glu Val Glu Gln Leu  Ser Lys Met 
    1475                 1480                 1485             


Val Ser  Glu Ala Lys Leu Arg  Ala Asp Glu Ala Lys  Gln Ser Ala 
    1490                 1495                 1500             


Glu Asp  Ile Leu Leu Lys Thr  Asn Ala Thr Lys Glu  Lys Met Asp 
    1505                 1510                 1515             


Lys Ser  Asn Glu Glu Leu Arg  Asn Leu Ile Lys Gln  Ile Arg Asn 
    1520                 1525                 1530             


Phe Leu  Thr Gln Asp Ser Ala  Asp Leu Asp Ser Ile  Glu Ala Val 
    1535                 1540                 1545             


Ala Asn  Glu Val Leu Lys Met  Glu Met Pro Ser Thr  Pro Gln Gln 
    1550                 1555                 1560             


Leu Gln  Asn Leu Thr Glu Asp  Ile Arg Glu Arg Val  Glu Ser Leu 
    1565                 1570                 1575             


Ser Gln  Val Glu Val Ile Leu  Gln His Ser Ala Ala  Asp Ile Ala 
    1580                 1585                 1590             


Arg Ala  Glu Met Leu Leu Glu  Glu Ala Lys Arg Ala  Ser Lys Ser 
    1595                 1600                 1605             


Ala Thr  Asp Val Lys Val Thr  Ala Asp Met Val Lys  Glu Ala Leu 
    1610                 1615                 1620             


Glu Glu  Ala Glu Lys Ala Gln  Val Ala Ala Glu Lys  Ala Ile Lys 
    1625                 1630                 1635             


Gln Ala  Asp Glu Asp Ile Gln  Gly Thr Gln Asn Leu  Leu Thr Ser 
    1640                 1645                 1650             


Ile Glu  Ser Glu Thr Ala Ala  Ser Glu Glu Thr Leu  Phe Asn Ala 
    1655                 1660                 1665             


Ser Gln  Arg Ile Ser Glu Leu  Glu Arg Asn Val Glu  Glu Leu Lys 
    1670                 1675                 1680             


Arg Lys  Ala Ala Gln Asn Ser  Gly Glu Ala Glu Tyr  Ile Glu Lys 
    1685                 1690                 1695             


Val Val  Tyr Thr Val Lys Gln  Ser Ala Glu Asp Val  Lys Lys Thr 
    1700                 1705                 1710             


Leu Asp  Gly Glu Leu Asp Glu  Lys Tyr Lys Lys Val  Glu Asn Leu 
    1715                 1720                 1725             


Ile Ala  Lys Lys Thr Glu Glu  Ser Ala Asp Ala Arg  Arg Lys Ala 
    1730                 1735                 1740             


Glu Met  Leu Gln Asn Glu Ala  Lys Thr Leu Leu Ala  Gln Ala Asn 
    1745                 1750                 1755             


Ser Lys  Leu Gln Leu Leu Lys  Asp Leu Glu Arg Lys  Tyr Glu Asp 
    1760                 1765                 1770             


Asn Gln  Arg Tyr Leu Glu Asp  Lys Ala Gln Glu Leu  Ala Arg Leu 
    1775                 1780                 1785             


Glu Gly  Glu Val Arg Ser Leu  Leu Lys Asp Ile Ser  Gln Lys Val 
    1790                 1795                 1800             


Ala Val  Tyr Ser Thr Cys Leu  
    1805                 1810 


<210>  7676
<211>  91
<212>  PRT
<213>  Homo Sapiens

<400>  7676

Met Gly Leu Leu Gln Leu Leu Ala Phe Ser Phe Leu Ala Leu Cys Arg 
1               5                   10                  15      


Ala Arg Val Arg Ala Gln Glu Pro Glu Phe Ser Tyr Gly Cys Ala Glu 
            20                  25                  30          


Gly Ser Cys Tyr Pro Ala Thr Gly Asp Leu Leu Ile Gly Arg Ala Gln 
        35                  40                  45              


Lys Leu Ser Val Thr Ser Thr Cys Gly Leu His Lys Pro Glu Pro Tyr 
    50                  55                  60                  


Cys Ile Val Ser His Leu Gln Glu Asp Lys Lys Cys Phe Ile Cys Asn 
65                  70                  75                  80  


Ser Gln Asp Pro Tyr His Glu Thr Leu Asn Pro 
                85                  90      


<210>  7677
<211>  1786
<212>  PRT
<213>  Homo Sapiens

<400>  7677

Met Gly Leu Leu Gln Leu Leu Ala Phe Ser Phe Leu Ala Leu Cys Arg 
1               5                   10                  15      


Ala Arg Val Arg Ala Gln Glu Pro Glu Phe Ser Tyr Gly Cys Ala Glu 
            20                  25                  30          


Gly Ser Cys Tyr Pro Ala Thr Gly Asp Leu Leu Ile Gly Arg Ala Gln 
        35                  40                  45              


Lys Leu Ser Val Thr Ser Thr Cys Gly Leu His Lys Pro Glu Pro Tyr 
    50                  55                  60                  


Cys Ile Val Ser His Leu Gln Glu Asp Lys Lys Cys Phe Ile Cys Asn 
65                  70                  75                  80  


Ser Gln Asp Pro Tyr His Glu Thr Leu Asn Pro Asp Ser His Leu Ile 
                85                  90                  95      


Glu Asn Val Val Thr Thr Phe Ala Pro Asn Arg Leu Lys Ile Trp Trp 
            100                 105                 110         


Gln Ser Glu Asn Gly Val Glu Asn Val Thr Ile Gln Leu Asp Leu Glu 
        115                 120                 125             


Ala Glu Phe His Phe Thr His Leu Ile Met Thr Phe Lys Thr Phe Arg 
    130                 135                 140                 


Pro Ala Ala Met Leu Ile Glu Arg Ser Ser Asp Phe Gly Lys Thr Trp 
145                 150                 155                 160 


Gly Val Tyr Arg Tyr Phe Ala Tyr Asp Cys Glu Ala Ser Phe Pro Gly 
                165                 170                 175     


Ile Ser Thr Gly Pro Met Lys Lys Val Asp Asp Ile Ile Cys Asp Ser 
            180                 185                 190         


Arg Tyr Ser Asp Ile Glu Pro Ser Thr Glu Gly Glu Val Ile Phe Arg 
        195                 200                 205             


Ala Leu Asp Pro Ala Phe Lys Ile Glu Asp Pro Tyr Ser Pro Arg Ile 
    210                 215                 220                 


Gln Asn Leu Leu Lys Ile Thr Asn Leu Arg Ile Lys Phe Val Lys Leu 
225                 230                 235                 240 


His Thr Leu Gly Asp Asn Leu Leu Asp Ser Arg Met Glu Ile Arg Glu 
                245                 250                 255     


Lys Tyr Tyr Tyr Ala Val Tyr Asp Met Val Val Arg Gly Asn Cys Phe 
            260                 265                 270         


Cys Tyr Gly His Ala Ser Glu Cys Ala Pro Val Asp Gly Phe Asn Glu 
        275                 280                 285             


Glu Val Glu Gly Met Val His Gly His Cys Met Cys Arg His Asn Thr 
    290                 295                 300                 


Lys Gly Leu Asn Cys Glu Leu Cys Met Asp Phe Tyr His Asp Leu Pro 
305                 310                 315                 320 


Trp Arg Pro Ala Glu Gly Arg Asn Ser Asn Ala Cys Lys Lys Cys Asn 
                325                 330                 335     


Cys Asn Glu His Ser Ile Ser Cys His Phe Asp Met Ala Val Tyr Leu 
            340                 345                 350         


Ala Thr Gly Asn Val Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn 
        355                 360                 365             


Thr Met Gly Arg Asn Cys Glu Gln Cys Lys Pro Phe Tyr Tyr Gln His 
    370                 375                 380                 


Pro Glu Arg Asp Ile Arg Asp Pro Asn Phe Cys Glu Arg Cys Thr Cys 
385                 390                 395                 400 


Asp Pro Ala Gly Ser Gln Asn Glu Gly Ile Cys Asp Ser Tyr Thr Asp 
                405                 410                 415     


Phe Ser Thr Gly Leu Ile Ala Gly Gln Cys Arg Cys Lys Leu Asn Val 
            420                 425                 430         


Glu Gly Glu His Cys Asp Val Cys Lys Glu Gly Phe Tyr Asp Leu Ser 
        435                 440                 445             


Ser Glu Asp Pro Phe Gly Cys Lys Ser Cys Ala Cys Asn Pro Leu Gly 
    450                 455                 460                 


Thr Ile Pro Gly Gly Asn Pro Cys Asp Ser Glu Thr Gly His Cys Tyr 
465                 470                 475                 480 


Cys Lys Arg Leu Val Thr Gly Gln His Cys Asp Gln Cys Leu Pro Glu 
                485                 490                 495     


His Trp Gly Leu Ser Asn Asp Leu Asp Gly Cys Arg Pro Cys Asp Cys 
            500                 505                 510         


Asp Leu Gly Gly Ala Leu Asn Asn Ser Cys Phe Ala Glu Ser Gly Gln 
        515                 520                 525             


Cys Ser Cys Arg Pro His Met Ile Gly Arg Gln Cys Asn Glu Val Glu 
    530                 535                 540                 


Pro Gly Tyr Tyr Phe Ala Thr Leu Asp His Tyr Leu Tyr Glu Ala Glu 
545                 550                 555                 560 


Glu Ala Asn Leu Gly Pro Gly Val Ser Ile Val Glu Arg Gln Tyr Ile 
                565                 570                 575     


Gln Asp Arg Ile Pro Ser Trp Thr Gly Ala Gly Phe Val Arg Val Pro 
            580                 585                 590         


Glu Gly Ala Tyr Leu Glu Phe Phe Ile Asp Asn Ile Pro Tyr Ser Met 
        595                 600                 605             


Glu Tyr Asp Ile Leu Ile Arg Tyr Glu Pro Gln Leu Pro Asp His Trp 
    610                 615                 620                 


Glu Lys Ala Val Ile Thr Val Gln Arg Pro Gly Arg Ile Pro Thr Ser 
625                 630                 635                 640 


Ser Arg Cys Gly Asn Thr Ile Pro Asp Asp Asp Asn Gln Val Val Ser 
                645                 650                 655     


Leu Ser Pro Gly Ser Arg Tyr Val Val Leu Pro Arg Pro Val Cys Phe 
            660                 665                 670         


Glu Lys Gly Thr Asn Tyr Thr Val Arg Leu Glu Leu Pro Gln Tyr Thr 
        675                 680                 685             


Ser Ser Asp Ser Asp Val Glu Ser Pro Tyr Thr Leu Ile Asp Ser Leu 
    690                 695                 700                 


Val Leu Met Pro Tyr Cys Lys Ser Leu Asp Ile Phe Thr Val Gly Gly 
705                 710                 715                 720 


Ser Gly Asp Gly Val Val Thr Asn Ser Ala Trp Glu Thr Phe Gln Arg 
                725                 730                 735     


Tyr Arg Cys Leu Glu Asn Ser Arg Ser Val Val Lys Thr Pro Met Thr 
            740                 745                 750         


Asp Val Cys Arg Asn Ile Ile Phe Ser Ile Ser Ala Leu Leu His Gln 
        755                 760                 765             


Thr Gly Leu Ala Cys Glu Cys Asp Pro Gln Gly Ser Leu Ser Ser Val 
    770                 775                 780                 


Cys Asp Pro Asn Gly Gly Gln Cys Gln Cys Arg Pro Asn Val Val Gly 
785                 790                 795                 800 


Arg Thr Cys Asn Arg Cys Ala Pro Gly Thr Phe Gly Phe Gly Pro Ser 
                805                 810                 815     


Gly Cys Lys Pro Cys Glu Cys His Leu Gln Gly Ser Val Asn Ala Phe 
            820                 825                 830         


Cys Asn Pro Val Thr Gly Gln Cys His Cys Phe Gln Gly Val Tyr Ala 
        835                 840                 845             


Arg Gln Cys Asp Arg Cys Leu Pro Gly His Trp Gly Phe Pro Ser Cys 
    850                 855                 860                 


Gln Pro Cys Gln Cys Asn Gly His Ala Asp Asp Cys Asp Pro Val Thr 
865                 870                 875                 880 


Gly Glu Cys Leu Asn Cys Gln Asp Tyr Thr Met Gly His Asn Cys Glu 
                885                 890                 895     


Arg Cys Leu Ala Gly Tyr Tyr Gly Asp Pro Ile Ile Gly Ser Gly Asp 
            900                 905                 910         


His Cys Arg Pro Cys Pro Cys Pro Asp Gly Pro Asp Ser Gly Arg Gln 
        915                 920                 925             


Phe Ala Arg Ser Cys Tyr Gln Asp Pro Val Thr Leu Gln Leu Ala Cys 
    930                 935                 940                 


Val Cys Asp Pro Gly Tyr Ile Gly Ser Arg Cys Asp Asp Cys Ala Ser 
945                 950                 955                 960 


Gly Tyr Phe Gly Asn Pro Ser Glu Val Gly Gly Ser Cys Gln Pro Cys 
                965                 970                 975     


Gln Cys His Asn Asn Ile Asp Thr Thr Asp Pro Glu Ala Cys Asp Lys 
            980                 985                 990         


Glu Thr Gly Arg Cys Leu Lys Cys  Leu Tyr His Thr Glu  Gly Glu His 
        995                 1000                 1005             


Cys Gln  Phe Cys Arg Phe Gly  Tyr Tyr Gly Asp Ala  Leu Gln Gln 
    1010                 1015                 1020             


Asp Cys  Arg Lys Cys Val Cys  Asn Tyr Leu Gly Thr  Val Gln Glu 
    1025                 1030                 1035             


His Cys  Asn Gly Ser Asp Cys  Gln Cys Asp Lys Ala  Thr Gly Gln 
    1040                 1045                 1050             


Cys Leu  Cys Leu Pro Asn Val  Ile Gly Gln Asn Cys  Asp Arg Cys 
    1055                 1060                 1065             


Ala Pro  Asn Thr Trp Gln Leu  Ala Ser Gly Thr Gly  Cys Asp Pro 
    1070                 1075                 1080             


Cys Asn  Cys Asn Ala Ala His  Ser Phe Gly Pro Ser  Cys Asn Glu 
    1085                 1090                 1095             


Phe Thr  Gly Gln Cys Gln Cys  Met Pro Gly Phe Gly  Gly Arg Thr 
    1100                 1105                 1110             


Cys Ser  Glu Cys Gln Glu Leu  Phe Trp Gly Asp Pro  Asp Val Glu 
    1115                 1120                 1125             


Cys Arg  Ala Cys Asp Cys Asp  Pro Arg Gly Ile Glu  Thr Pro Gln 
    1130                 1135                 1140             


Cys Asp  Gln Ser Thr Gly Gln  Cys Val Cys Val Glu  Gly Val Glu 
    1145                 1150                 1155             


Gly Pro  Arg Cys Asp Lys Cys  Thr Arg Gly Tyr Ser  Gly Val Phe 
    1160                 1165                 1170             


Pro Asp  Cys Thr Pro Cys His  Gln Cys Phe Ala Leu  Trp Asp Val 
    1175                 1180                 1185             


Ile Ile  Ala Glu Leu Thr Asn  Arg Thr His Arg Phe  Leu Glu Lys 
    1190                 1195                 1200             


Ala Lys  Ala Leu Lys Ile Ser  Gly Val Ile Gly Pro  Tyr Arg Glu 
    1205                 1210                 1215             


Thr Val  Asp Ser Val Glu Arg  Lys Val Ser Glu Ile  Lys Asp Ile 
    1220                 1225                 1230             


Leu Ala  Gln Ser Pro Ala Ala  Glu Pro Leu Lys Asn  Ile Gly Asn 
    1235                 1240                 1245             


Leu Phe  Glu Glu Ala Glu Lys  Leu Ile Lys Asp Val  Thr Glu Met 
    1250                 1255                 1260             


Met Ala  Gln Val Glu Val Lys  Leu Ser Asp Thr Thr  Ser Gln Ser 
    1265                 1270                 1275             


Asn Ser  Thr Ala Lys Glu Leu  Asp Ser Leu Gln Thr  Glu Ala Glu 
    1280                 1285                 1290             


Ser Leu  Asp Asn Thr Val Lys  Glu Leu Ala Glu Gln  Leu Glu Phe 
    1295                 1300                 1305             


Ile Lys  Asn Ser Asp Ile Arg  Gly Ala Leu Asp Ser  Ile Thr Lys 
    1310                 1315                 1320             


Tyr Phe  Gln Met Ser Leu Glu  Ala Glu Glu Arg Val  Asn Ala Ser 
    1325                 1330                 1335             


Thr Thr  Glu Pro Asn Ser Thr  Val Glu Gln Ser Ala  Leu Met Arg 
    1340                 1345                 1350             


Asp Arg  Val Glu Asp Val Met  Met Glu Arg Glu Ser  Gln Phe Lys 
    1355                 1360                 1365             


Glu Lys  Gln Glu Glu Gln Ala  Arg Leu Leu Asp Glu  Leu Ala Gly 
    1370                 1375                 1380             


Lys Leu  Gln Ser Leu Asp Leu  Ser Ala Ala Ala Glu  Met Thr Cys 
    1385                 1390                 1395             


Gly Thr  Pro Pro Gly Ala Ser  Cys Ser Glu Thr Glu  Cys Gly Gly 
    1400                 1405                 1410             


Pro Asn  Cys Arg Thr Asp Glu  Gly Glu Arg Lys Cys  Gly Gly Pro 
    1415                 1420                 1425             


Gly Cys  Gly Gly Leu Val Thr  Val Ala His Asn Ala  Trp Gln Lys 
    1430                 1435                 1440             


Ala Met  Asp Leu Asp Gln Asp  Val Leu Ser Ala Leu  Ala Glu Val 
    1445                 1450                 1455             


Glu Gln  Leu Ser Lys Met Val  Ser Glu Ala Lys Leu  Arg Ala Asp 
    1460                 1465                 1470             


Glu Ala  Lys Gln Ser Ala Glu  Asp Ile Leu Leu Lys  Thr Asn Ala 
    1475                 1480                 1485             


Thr Lys  Glu Lys Met Asp Lys  Ser Asn Glu Glu Leu  Arg Asn Leu 
    1490                 1495                 1500             


Ile Lys  Gln Ile Arg Asn Phe  Leu Thr Gln Asp Ser  Ala Asp Leu 
    1505                 1510                 1515             


Asp Ser  Ile Glu Ala Val Ala  Asn Glu Val Leu Lys  Met Glu Met 
    1520                 1525                 1530             


Pro Ser  Thr Pro Gln Gln Leu  Gln Asn Leu Thr Glu  Asp Ile Arg 
    1535                 1540                 1545             


Glu Arg  Val Glu Ser Leu Ser  Gln Val Glu Val Ile  Leu Gln His 
    1550                 1555                 1560             


Ser Ala  Ala Asp Ile Ala Arg  Ala Glu Met Leu Leu  Glu Glu Ala 
    1565                 1570                 1575             


Lys Arg  Ala Ser Lys Ser Ala  Thr Asp Val Lys Val  Thr Ala Asp 
    1580                 1585                 1590             


Met Val  Lys Glu Ala Leu Glu  Glu Ala Glu Lys Ala  Gln Val Ala 
    1595                 1600                 1605             


Ala Glu  Lys Ala Ile Lys Gln  Ala Asp Glu Asp Ile  Gln Gly Thr 
    1610                 1615                 1620             


Gln Asn  Leu Leu Thr Ser Ile  Glu Ser Glu Thr Ala  Ala Ser Glu 
    1625                 1630                 1635             


Glu Thr  Leu Phe Asn Ala Ser  Gln Arg Ile Ser Glu  Leu Glu Arg 
    1640                 1645                 1650             


Asn Val  Glu Glu Leu Lys Arg  Lys Ala Ala Gln Asn  Ser Gly Glu 
    1655                 1660                 1665             


Ala Glu  Tyr Ile Glu Lys Val  Val Tyr Thr Val Lys  Gln Ser Ala 
    1670                 1675                 1680             


Glu Asp  Val Lys Lys Thr Leu  Asp Gly Glu Leu Asp  Glu Lys Tyr 
    1685                 1690                 1695             


Lys Lys  Val Glu Asn Leu Ile  Ala Lys Lys Thr Glu  Glu Ser Ala 
    1700                 1705                 1710             


Asp Ala  Arg Arg Lys Ala Glu  Met Leu Gln Asn Glu  Ala Lys Thr 
    1715                 1720                 1725             


Leu Leu  Ala Gln Ala Asn Ser  Lys Leu Gln Leu Leu  Lys Asp Leu 
    1730                 1735                 1740             


Glu Arg  Lys Tyr Glu Asp Asn  Gln Arg Tyr Leu Glu  Asp Lys Ala 
    1745                 1750                 1755             


Gln Glu  Leu Ala Arg Leu Glu  Gly Glu Val Arg Ser  Leu Leu Lys 
    1760                 1765                 1770             


Asp Ile  Ser Gln Lys Val Ala  Val Tyr Ser Thr Cys  Leu 
    1775                 1780                 1785     


<210>  7678
<211>  850
<212>  PRT
<213>  Homo Sapiens

<400>  7678

Met Gly Leu Leu Gln Leu Leu Ala Phe Ser Phe Leu Ala Leu Cys Arg 
1               5                   10                  15      


Ala Arg Val Arg Ala Gln Glu Pro Glu Phe Ser Tyr Gly Cys Ala Glu 
            20                  25                  30          


Gly Ser Cys Tyr Pro Ala Thr Gly Asp Leu Leu Ile Gly Arg Ala Gln 
        35                  40                  45              


Lys Leu Ser Val Thr Ser Thr Cys Gly Leu His Lys Pro Glu Pro Tyr 
    50                  55                  60                  


Cys Ile Val Ser His Leu Gln Glu Asp Lys Lys Cys Phe Ile Cys Asn 
65                  70                  75                  80  


Ser Gln Asp Pro Tyr His Glu Thr Leu Asn Pro Asp Ser His Leu Ile 
                85                  90                  95      


Glu Asn Val Val Thr Thr Phe Ala Pro Asn Arg Leu Lys Ile Trp Trp 
            100                 105                 110         


Gln Ser Glu Asn Gly Val Glu Asn Val Thr Ile Gln Leu Asp Leu Glu 
        115                 120                 125             


Ala Glu Phe His Phe Thr His Leu Ile Met Thr Phe Lys Thr Phe Arg 
    130                 135                 140                 


Pro Ala Ala Met Leu Ile Glu Arg Ser Ser Asp Phe Gly Lys Thr Trp 
145                 150                 155                 160 


Gly Val Tyr Arg Tyr Phe Ala Tyr Asp Cys Glu Ala Ser Phe Pro Gly 
                165                 170                 175     


Ile Ser Thr Gly Pro Met Lys Lys Val Asp Asp Ile Ile Cys Asp Ser 
            180                 185                 190         


Arg Tyr Ser Asp Ile Glu Pro Ser Thr Glu Gly Glu Val Ile Phe Arg 
        195                 200                 205             


Ala Leu Asp Pro Ala Phe Lys Ile Glu Asp Pro Tyr Ser Pro Arg Ile 
    210                 215                 220                 


Gln Asn Leu Leu Lys Ile Thr Asn Leu Arg Ile Lys Phe Val Lys Leu 
225                 230                 235                 240 


His Thr Leu Gly Asp Asn Leu Leu Asp Ser Arg Met Glu Ile Arg Glu 
                245                 250                 255     


Lys Tyr Tyr Tyr Ala Val Tyr Asp Met Val Val Arg Gly Asn Cys Phe 
            260                 265                 270         


Cys Tyr Gly His Ala Ser Glu Cys Ala Pro Val Asp Gly Phe Asn Glu 
        275                 280                 285             


Glu Val Glu Gly Met Val His Gly His Cys Met Cys Arg His Asn Thr 
    290                 295                 300                 


Lys Gly Leu Asn Cys Glu Leu Cys Met Asp Phe Tyr His Asp Leu Pro 
305                 310                 315                 320 


Trp Arg Pro Ala Glu Gly Arg Asn Ser Asn Ala Cys Lys Lys Cys Asn 
                325                 330                 335     


Cys Asn Glu His Ser Ile Ser Cys His Phe Asp Met Ala Val Tyr Leu 
            340                 345                 350         


Ala Thr Gly Asn Val Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn 
        355                 360                 365             


Thr Met Gly Arg Asn Cys Glu Gln Cys Lys Pro Phe Tyr Tyr Gln His 
    370                 375                 380                 


Pro Glu Arg Asp Ile Arg Asp Pro Asn Phe Cys Glu Arg Cys Thr Cys 
385                 390                 395                 400 


Asp Pro Ala Gly Ser Gln Asn Glu Gly Ile Cys Asp Ser Tyr Thr Asp 
                405                 410                 415     


Phe Ser Thr Gly Leu Ile Ala Gly Gln Cys Arg Cys Lys Leu Asn Val 
            420                 425                 430         


Glu Gly Glu His Cys Asp Val Cys Lys Glu Gly Phe Tyr Asp Leu Ser 
        435                 440                 445             


Ser Glu Asp Pro Phe Gly Cys Lys Ser Cys Ala Cys Asn Pro Leu Gly 
    450                 455                 460                 


Thr Ile Pro Gly Gly Asn Pro Cys Asp Ser Glu Thr Gly His Cys Tyr 
465                 470                 475                 480 


Cys Lys Arg Leu Val Thr Gly Gln His Cys Asp Gln Cys Leu Pro Glu 
                485                 490                 495     


His Trp Gly Leu Ser Asn Asp Leu Asp Gly Cys Arg Pro Cys Asp Cys 
            500                 505                 510         


Asp Leu Gly Gly Ala Leu Asn Asn Ser Cys Phe Ala Glu Ser Gly Gln 
        515                 520                 525             


Cys Ser Cys Arg Pro His Met Ile Gly Arg Gln Cys Asn Glu Val Glu 
    530                 535                 540                 


Pro Gly Tyr Tyr Phe Ala Thr Leu Asp His Tyr Leu Tyr Glu Ala Glu 
545                 550                 555                 560 


Glu Ala Asn Leu Gly Pro Gly Val Ser Ile Val Glu Arg Gln Tyr Ile 
                565                 570                 575     


Gln Asp Arg Ile Pro Ser Trp Thr Gly Ala Gly Phe Val Arg Val Pro 
            580                 585                 590         


Glu Gly Ala Tyr Leu Glu Phe Phe Ile Asp Asn Ile Pro Tyr Ser Met 
        595                 600                 605             


Glu Tyr Asp Ile Leu Ile Arg Tyr Glu Pro Gln Leu Pro Asp His Trp 
    610                 615                 620                 


Glu Lys Ala Val Ile Thr Val Gln Arg Pro Gly Arg Ile Pro Thr Ser 
625                 630                 635                 640 


Ser Arg Cys Gly Asn Thr Ile Pro Asp Asp Asp Asn Gln Val Val Ser 
                645                 650                 655     


Leu Ser Pro Gly Ser Arg Tyr Val Val Leu Pro Arg Pro Val Cys Phe 
            660                 665                 670         


Glu Lys Gly Thr Asn Tyr Thr Val Arg Leu Glu Leu Pro Gln Tyr Thr 
        675                 680                 685             


Ser Ser Asp Ser Asp Val Glu Ser Pro Tyr Thr Leu Ile Asp Ser Leu 
    690                 695                 700                 


Val Leu Met Pro Tyr Cys Lys Ser Leu Asp Ile Phe Thr Val Gly Gly 
705                 710                 715                 720 


Ser Gly Asp Gly Val Val Thr Asn Ser Ala Trp Glu Thr Phe Gln Arg 
                725                 730                 735     


Tyr Arg Cys Leu Glu Asn Ser Arg Ser Val Val Lys Thr Pro Met Thr 
            740                 745                 750         


Asp Val Cys Arg Asn Ile Ile Phe Ser Ile Ser Ala Leu Leu His Gln 
        755                 760                 765             


Thr Gly Leu Ala Cys Glu Cys Asp Pro Gln Gly Ser Leu Ser Ser Val 
    770                 775                 780                 


Cys Asp Pro Asn Gly Gly Gln Cys Gln Cys Arg Pro Asn Val Val Gly 
785                 790                 795                 800 


Arg Thr Cys Asn Arg Cys Ala Pro Gly Thr Phe Gly Phe Gly Pro Ser 
                805                 810                 815     


Gly Cys Lys Arg Arg Phe Leu Lys Ser Ile Val Met His Ser Phe Arg 
            820                 825                 830         


Leu Thr Gln Pro Leu Trp Gln Gly Ser Ile Ala Ala Glu Pro Met Leu 
        835                 840                 845             


Pro Ser 
    850 


<210>  7679
<211>  183
<212>  PRT
<213>  Homo Sapiens

<400>  7679

Met Gly Leu Leu Gln Leu Leu Ala Phe Ser Phe Leu Glu Thr Ala Gly 
1               5                   10                  15      


Pro Gly Ala Ser Leu Glu Trp Arg Ser Leu Glu Thr Thr Pro Glu Pro 
            20                  25                  30          


Gln Gly Leu Ser Met Gly Ser Pro Ser Ser Gly Lys Arg Arg Pro Pro 
        35                  40                  45              


Arg Ala Pro Ala Pro Arg Pro Gln Arg Ser Ala Gly Asp Pro Arg Ala 
    50                  55                  60                  


Cys Thr His Thr His Ser Arg Phe Pro Ser Ser Gln Ile Ser Thr Arg 
65                  70                  75                  80  


Thr Leu Thr Pro Arg Met Arg Gly Leu Pro Arg Ala Arg Gly Phe Thr 
                85                  90                  95      


Cys Val Ala Leu Cys Arg Ala Arg Val Arg Ala Gln Glu Pro Glu Phe 
            100                 105                 110         


Ser Tyr Gly Cys Ala Glu Gly Ser Cys Tyr Pro Ala Thr Gly Asp Leu 
        115                 120                 125             


Leu Ile Gly Arg Ala Gln Lys Leu Ser Val Thr Ser Thr Cys Gly Leu 
    130                 135                 140                 


His Lys Pro Glu Pro Tyr Cys Ile Val Ser His Leu Gln Glu Asp Lys 
145                 150                 155                 160 


Lys Cys Phe Ile Cys Asn Ser Gln Asp Pro Tyr His Glu Thr Leu Asn 
                165                 170                 175     


Pro Asp Ser His Leu Ile Glu 
            180             


<210>  7680
<211>  1798
<212>  PRT
<213>  Homo Sapiens

<400>  7680

Met Glu Leu Thr Ser Arg Glu Arg Gly Arg Gly Gln Pro Leu Pro Trp 
1               5                   10                  15      


Glu Leu Arg Leu Gly Leu Leu Leu Ser Val Leu Ala Ala Thr Leu Ala 
            20                  25                  30          


Gln Ala Pro Ala Pro Asp Val Pro Gly Cys Ser Arg Gly Ser Cys Tyr 
        35                  40                  45              


Pro Ala Thr Gly Asp Leu Leu Val Gly Arg Ala Asp Arg Leu Thr Ala 
    50                  55                  60                  


Ser Ser Thr Cys Gly Leu Asn Gly Pro Gln Pro Tyr Cys Ile Val Ser 
65                  70                  75                  80  


His Leu Gln Asp Glu Lys Lys Cys Phe Leu Cys Asp Ser Arg Arg Pro 
                85                  90                  95      


Phe Ser Ala Arg Asp Asn Pro His Ser His Arg Ile Gln Asn Val Val 
            100                 105                 110         


Thr Ser Phe Ala Pro Gln Arg Arg Ala Ala Trp Trp Gln Ser Glu Asn 
        115                 120                 125             


Gly Ile Pro Ala Val Thr Ile Gln Leu Asp Leu Glu Ala Glu Phe His 
    130                 135                 140                 


Phe Thr His Leu Ile Met Thr Phe Lys Thr Phe Arg Pro Ala Ala Met 
145                 150                 155                 160 


Leu Val Glu Arg Ser Ala Asp Phe Gly Arg Thr Trp His Val Tyr Arg 
                165                 170                 175     


Tyr Phe Ser Tyr Asp Cys Gly Ala Asp Phe Pro Gly Val Pro Leu Ala 
            180                 185                 190         


Pro Pro Arg His Trp Asp Asp Val Val Cys Glu Ser Arg Tyr Ser Glu 
        195                 200                 205             


Ile Glu Pro Ser Thr Glu Gly Glu Val Ile Tyr Arg Val Leu Asp Pro 
    210                 215                 220                 


Ala Ile Pro Ile Pro Asp Pro Tyr Ser Ser Arg Ile Gln Asn Leu Leu 
225                 230                 235                 240 


Lys Ile Thr Asn Leu Arg Val Asn Leu Thr Arg Leu His Thr Leu Gly 
                245                 250                 255     


Asp Asn Leu Leu Asp Pro Arg Arg Glu Ile Arg Glu Lys Tyr Tyr Tyr 
            260                 265                 270         


Ala Leu Tyr Glu Leu Val Val Arg Gly Asn Cys Phe Cys Tyr Gly His 
        275                 280                 285             


Ala Ser Glu Cys Ala Pro Ala Pro Gly Ala Pro Ala His Ala Glu Gly 
    290                 295                 300                 


Met Val His Gly Ala Cys Ile Cys Lys His Asn Thr Arg Gly Leu Asn 
305                 310                 315                 320 


Cys Glu Gln Cys Gln Asp Phe Tyr Arg Asp Leu Pro Trp Arg Pro Ala 
                325                 330                 335     


Glu Asp Gly His Ser His Ala Cys Arg Lys Cys Glu Cys His Gly His 
            340                 345                 350         


Thr His Ser Cys His Phe Asp Met Ala Val Tyr Leu Ala Ser Gly Asn 
        355                 360                 365             


Val Ser Gly Gly Val Cys Asp Gly Cys Gln His Asn Thr Ala Gly Arg 
    370                 375                 380                 


His Cys Glu Leu Cys Arg Pro Phe Phe Tyr Arg Asp Pro Thr Lys Asp 
385                 390                 395                 400 


Leu Arg Asp Pro Ala Val Cys Arg Ser Cys Asp Cys Asp Pro Met Gly 
                405                 410                 415     


Ser Gln Asp Gly Gly Arg Cys Asp Ser His Asp Asp Pro Ala Leu Gly 
            420                 425                 430         


Leu Val Ser Gly Gln Cys Arg Cys Lys Glu His Val Val Gly Thr Arg 
        435                 440                 445             


Cys Gln Gln Cys Arg Asp Gly Phe Phe Gly Leu Ser Ile Ser Asp Arg 
    450                 455                 460                 


Leu Gly Cys Arg Arg Cys Gln Cys Asn Ala Arg Gly Thr Val Pro Gly 
465                 470                 475                 480 


Ser Thr Pro Cys Asp Pro Asn Ser Gly Ser Cys Tyr Cys Lys Arg Leu 
                485                 490                 495     


Val Thr Gly Arg Gly Cys Asp Arg Cys Leu Pro Gly His Trp Gly Leu 
            500                 505                 510         


Ser His Asp Leu Leu Gly Cys Arg Pro Cys Asp Cys Asp Val Gly Gly 
        515                 520                 525             


Ala Leu Asp Pro Gln Cys Asp Glu Gly Thr Gly Gln Cys His Cys Arg 
    530                 535                 540                 


Gln His Met Val Gly Arg Arg Cys Glu Gln Val Gln Pro Gly Tyr Phe 
545                 550                 555                 560 


Arg Pro Phe Leu Asp His Leu Ile Trp Glu Ala Glu Asp Thr Arg Gly 
                565                 570                 575     


Gln Val Leu Asp Val Val Glu Arg Leu Val Thr Pro Gly Glu Thr Pro 
            580                 585                 590         


Ser Trp Thr Gly Ser Gly Phe Val Arg Leu Gln Glu Gly Gln Thr Leu 
        595                 600                 605             


Glu Phe Leu Val Ala Ser Val Pro Lys Ala Met Asp Tyr Asp Leu Leu 
    610                 615                 620                 


Leu Arg Leu Glu Pro Gln Val Pro Glu Gln Trp Ala Glu Leu Glu Leu 
625                 630                 635                 640 


Ile Val Gln Arg Pro Gly Pro Val Pro Ala His Ser Leu Cys Gly His 
                645                 650                 655     


Leu Val Pro Lys Asp Asp Arg Ile Gln Gly Thr Leu Gln Pro His Ala 
            660                 665                 670         


Arg Tyr Leu Ile Phe Pro Asn Pro Val Cys Leu Glu Pro Gly Ile Ser 
        675                 680                 685             


Tyr Lys Leu His Leu Lys Leu Val Arg Thr Gly Gly Ser Ala Gln Pro 
    690                 695                 700                 


Glu Thr Pro Tyr Ser Gly Pro Gly Leu Leu Ile Asp Ser Leu Val Leu 
705                 710                 715                 720 


Leu Pro Arg Val Leu Val Leu Glu Met Phe Ser Gly Gly Asp Ala Ala 
                725                 730                 735     


Ala Leu Glu Arg Gln Ala Thr Phe Glu Arg Tyr Gln Cys His Glu Glu 
            740                 745                 750         


Gly Leu Val Pro Ser Lys Thr Ser Pro Ser Glu Ala Cys Ala Pro Leu 
        755                 760                 765             


Leu Ile Ser Leu Ser Thr Leu Ile Tyr Asn Gly Ala Leu Pro Cys Gln 
    770                 775                 780                 


Cys Asn Pro Gln Gly Ser Leu Ser Ser Glu Cys Asn Pro His Gly Gly 
785                 790                 795                 800 


Gln Cys Leu Cys Lys Pro Gly Val Val Gly Arg Arg Cys Asp Leu Cys 
                805                 810                 815     


Ala Pro Gly Tyr Tyr Gly Phe Gly Pro Thr Gly Cys Gln Ala Cys Gln 
            820                 825                 830         


Cys Ser His Glu Gly Ala Leu Ser Ser Leu Cys Glu Lys Thr Ser Gly 
        835                 840                 845             


Gln Cys Leu Cys Arg Thr Gly Ala Phe Gly Leu Arg Cys Asp Arg Cys 
    850                 855                 860                 


Gln Arg Gly Gln Trp Gly Phe Pro Ser Cys Arg Pro Cys Val Cys Asn 
865                 870                 875                 880 


Gly His Ala Asp Glu Cys Asn Thr His Thr Gly Ala Cys Leu Gly Cys 
                885                 890                 895     


Arg Asp His Thr Gly Gly Glu His Cys Glu Arg Cys Ile Ala Gly Phe 
            900                 905                 910         


His Gly Asp Pro Arg Leu Pro Tyr Gly Gly Gln Cys Arg Pro Cys Pro 
        915                 920                 925             


Cys Pro Glu Gly Pro Gly Ser Gln Arg His Phe Ala Thr Ser Cys His 
    930                 935                 940                 


Gln Asp Glu Tyr Ser Gln Gln Ile Val Cys His Cys Arg Ala Gly Tyr 
945                 950                 955                 960 


Thr Gly Leu Arg Cys Glu Ala Cys Ala Pro Gly His Phe Gly Asp Pro 
                965                 970                 975     


Ser Arg Pro Gly Gly Arg Cys Gln Leu Cys Glu Cys Ser Gly Asn Ile 
            980                 985                 990         


Asp Pro Met Asp Pro Asp Ala Cys  Asp Pro His Thr Gly  Gln Cys Leu 
        995                 1000                 1005             


Arg Cys  Leu His His Thr Glu  Gly Pro His Cys Ala  His Cys Lys 
    1010                 1015                 1020             


Pro Gly  Phe His Gly Gln Ala  Ala Arg Gln Ser Cys  His Arg Cys 
    1025                 1030                 1035             


Thr Cys  Asn Leu Leu Gly Thr  Asn Pro Gln Gln Cys  Pro Ser Pro 
    1040                 1045                 1050             


Asp Gln  Cys His Cys Asp Pro  Ser Ser Gly Gln Cys  Pro Cys Leu 
    1055                 1060                 1065             


Pro Asn  Val Gln Gly Pro Ser  Cys Asp Arg Cys Ala  Pro Asn Phe 
    1070                 1075                 1080             


Trp Asn  Leu Thr Ser Gly His  Gly Cys Gln Pro Cys  Ala Cys His 
    1085                 1090                 1095             


Pro Ser  Arg Ala Arg Gly Pro  Thr Cys Asn Glu Phe  Thr Gly Gln 
    1100                 1105                 1110             


Cys His  Cys Arg Ala Gly Phe  Gly Gly Arg Thr Cys  Ser Glu Cys 
    1115                 1120                 1125             


Gln Glu  Leu His Trp Gly Asp  Pro Gly Leu Gln Cys  His Ala Cys 
    1130                 1135                 1140             


Asp Cys  Asp Ser Arg Gly Ile  Asp Thr Pro Gln Cys  His Arg Phe 
    1145                 1150                 1155             


Thr Gly  His Cys Ser Cys Arg  Pro Gly Val Ser Gly  Val Arg Cys 
    1160                 1165                 1170             


Asp Gln  Cys Ala Arg Gly Phe  Ser Gly Ile Phe Pro  Ala Cys His 
    1175                 1180                 1185             


Pro Cys  His Ala Cys Phe Gly  Asp Trp Asp Arg Val  Val Gln Asp 
    1190                 1195                 1200             


Leu Ala  Ala Arg Thr Gln Arg  Leu Glu Gln Arg Ala  Gln Glu Leu 
    1205                 1210                 1215             


Gln Gln  Thr Gly Val Leu Gly  Ala Phe Glu Ser Ser  Phe Trp His 
    1220                 1225                 1230             


Met Gln  Glu Lys Leu Gly Ile  Val Gln Gly Ile Val  Gly Ala Arg 
    1235                 1240                 1245             


Asn Thr  Ser Ala Ala Ser Thr  Ala Gln Leu Val Glu  Ala Thr Glu 
    1250                 1255                 1260             


Glu Leu  Arg Arg Glu Ile Gly  Glu Ala Thr Glu His  Leu Thr Gln 
    1265                 1270                 1275             


Leu Glu  Ala Asp Leu Thr Asp  Val Gln Asp Glu Asn  Phe Asn Ala 
    1280                 1285                 1290             


Asn His  Ala Leu Ser Gly Leu  Glu Arg Asp Arg Leu  Ala Leu Asn 
    1295                 1300                 1305             


Leu Thr  Leu Arg Gln Leu Asp  Gln His Leu Asp Leu  Leu Lys His 
    1310                 1315                 1320             


Ser Asn  Phe Leu Gly Ala Tyr  Asp Ser Ile Arg His  Ala His Ser 
    1325                 1330                 1335             


Gln Ser  Ala Glu Ala Glu Arg  Arg Ala Asn Thr Ser  Ala Leu Ala 
    1340                 1345                 1350             


Val Pro  Ser Pro Val Ser Asn  Ser Ala Ser Ala Arg  His Arg Thr 
    1355                 1360                 1365             


Glu Ala  Leu Met Asp Ala Gln  Lys Glu Asp Phe Asn  Ser Lys His 
    1370                 1375                 1380             


Met Ala  Asn Gln Arg Ala Leu  Gly Lys Leu Ser Ala  His Thr His 
    1385                 1390                 1395             


Thr Leu  Ser Leu Thr Asp Ile  Asn Glu Leu Val Cys  Gly Ala Pro 
    1400                 1405                 1410             


Gly Asp  Ala Pro Cys Ala Thr  Ser Pro Cys Gly Gly  Ala Gly Cys 
    1415                 1420                 1425             


Arg Asp  Glu Asp Gly Gln Pro  Arg Cys Gly Gly Leu  Ser Cys Asn 
    1430                 1435                 1440             


Gly Ala  Ala Ala Thr Ala Asp  Leu Ala Leu Gly Arg  Ala Arg His 
    1445                 1450                 1455             


Thr Gln  Ala Glu Leu Gln Arg  Ala Leu Ala Glu Gly  Gly Ser Ile 
    1460                 1465                 1470             


Leu Ser  Arg Val Ala Glu Thr  Arg Arg Gln Ala Ser  Glu Ala Gln 
    1475                 1480                 1485             


Gln Arg  Ala Gln Ala Ala Leu  Asp Lys Ala Asn Ala  Ser Arg Gly 
    1490                 1495                 1500             


Gln Val  Glu Gln Ala Asn Gln  Glu Leu Gln Glu Leu  Ile Gln Ser 
    1505                 1510                 1515             


Val Lys  Asp Phe Leu Asn Gln  Glu Gly Ala Asp Pro  Asp Ser Ile 
    1520                 1525                 1530             


Glu Met  Val Ala Thr Arg Val  Leu Glu Leu Ser Ile  Pro Ala Ser 
    1535                 1540                 1545             


Ala Glu  Gln Ile Gln His Leu  Ala Gly Ala Ile Ala  Glu Arg Val 
    1550                 1555                 1560             


Arg Ser  Leu Ala Asp Val Asp  Ala Ile Leu Ala Arg  Thr Val Gly 
    1565                 1570                 1575             


Asp Val  Arg Arg Ala Glu Gln  Leu Leu Gln Asp Ala  Arg Arg Ala 
    1580                 1585                 1590             


Arg Ser  Trp Ala Glu Asp Glu  Lys Gln Lys Ala Glu  Thr Val Gln 
    1595                 1600                 1605             


Ala Ala  Leu Glu Glu Ala Gln  Arg Ala Gln Gly Ile  Ala Gln Gly 
    1610                 1615                 1620             


Ala Ile  Arg Gly Ala Val Ala  Asp Thr Arg Asp Thr  Glu Gln Thr 
    1625                 1630                 1635             


Leu Tyr  Gln Val Gln Glu Arg  Met Ala Gly Ala Glu  Arg Ala Leu 
    1640                 1645                 1650             


Ser Ser  Ala Gly Glu Arg Ala  Arg Gln Leu Asp Ala  Leu Leu Glu 
    1655                 1660                 1665             


Ala Leu  Lys Leu Lys Arg Ala  Gly Asn Ser Leu Ala  Ala Ser Thr 
    1670                 1675                 1680             


Ala Glu  Glu Thr Ala Gly Ser  Ala Gln Gly Arg Ala  Gln Glu Ala 
    1685                 1690                 1695             


Glu Gln  Leu Leu Arg Gly Pro  Leu Gly Asp Gln Tyr  Gln Thr Val 
    1700                 1705                 1710             


Lys Ala  Leu Ala Glu Arg Lys  Ala Gln Gly Val Leu  Ala Ala Gln 
    1715                 1720                 1725             


Ala Arg  Ala Glu Gln Leu Arg  Asp Glu Ala Arg Asp  Leu Leu Gln 
    1730                 1735                 1740             


Ala Ala  Gln Asp Lys Leu Gln  Arg Leu Gln Glu Leu  Glu Gly Thr 
    1745                 1750                 1755             


Tyr Glu  Glu Asn Glu Arg Ala  Leu Glu Ser Lys Ala  Ala Gln Leu 
    1760                 1765                 1770             


Asp Gly  Leu Glu Ala Arg Met  Arg Ser Val Leu Gln  Ala Ile Asn 
    1775                 1780                 1785             


Leu Gln  Val Gln Ile Tyr Asn  Thr Cys Gln 
    1790                 1795             


<210>  7681
<211>  1798
<212>  PRT
<213>  Homo Sapiens

<400>  7681

Met Glu Leu Thr Ser Arg Glu Arg Gly Arg Gly Gln Pro Leu Pro Trp 
1               5                   10                  15      


Glu Leu Arg Leu Gly Leu Leu Leu Ser Val Leu Ala Ala Thr Leu Ala 
            20                  25                  30          


Gln Ala Pro Ala Pro Asp Val Pro Gly Cys Ser Arg Gly Ser Cys Tyr 
        35                  40                  45              


Pro Ala Thr Gly Asp Leu Leu Val Gly Arg Ala Asp Arg Leu Thr Ala 
    50                  55                  60                  


Ser Ser Thr Cys Gly Leu Asn Gly Pro Gln Pro Tyr Cys Ile Val Ser 
65                  70                  75                  80  


His Leu Gln Asp Glu Lys Lys Cys Phe Leu Cys Asp Ser Arg Arg Pro 
                85                  90                  95      


Phe Ser Ala Arg Asp Asn Pro His Ser His Arg Ile Gln Asn Val Val 
            100                 105                 110         


Thr Ser Phe Ala Pro Gln Arg Arg Ala Ala Trp Trp Gln Ser Glu Asn 
        115                 120                 125             


Gly Ile Pro Ala Val Thr Ile Gln Leu Asp Leu Glu Ala Glu Phe His 
    130                 135                 140                 


Phe Thr His Leu Ile Met Thr Phe Lys Thr Phe Arg Pro Ala Ala Met 
145                 150                 155                 160 


Leu Val Glu Arg Ser Ala Asp Phe Gly Arg Thr Trp His Val Tyr Arg 
                165                 170                 175     


Tyr Phe Ser Tyr Asp Cys Gly Ala Asp Phe Pro Gly Val Pro Leu Ala 
            180                 185                 190         


Pro Pro Arg His Trp Asp Asp Val Val Cys Glu Ser Arg Tyr Ser Glu 
        195                 200                 205             


Ile Glu Pro Ser Thr Glu Gly Glu Val Ile Tyr Arg Val Leu Asp Pro 
    210                 215                 220                 


Ala Ile Pro Ile Pro Asp Pro Tyr Ser Ser Arg Ile Gln Asn Leu Leu 
225                 230                 235                 240 


Lys Ile Thr Asn Leu Arg Val Asn Leu Thr Arg Leu His Thr Leu Gly 
                245                 250                 255     


Asp Asn Leu Leu Asp Pro Arg Arg Glu Ile Arg Glu Lys Tyr Tyr Tyr 
            260                 265                 270         


Ala Leu Tyr Glu Leu Val Val Arg Gly Asn Cys Phe Cys Tyr Gly His 
        275                 280                 285             


Ala Ser Glu Cys Ala Pro Ala Pro Gly Ala Pro Ala His Ala Glu Gly 
    290                 295                 300                 


Met Val His Gly Ala Cys Ile Cys Lys His Asn Thr Arg Gly Leu Asn 
305                 310                 315                 320 


Cys Glu Gln Cys Gln Asp Phe Tyr Arg Asp Leu Pro Trp Arg Pro Ala 
                325                 330                 335     


Glu Asp Gly His Ser His Ala Cys Arg Lys Cys Glu Cys His Gly His 
            340                 345                 350         


Thr His Ser Cys His Phe Asp Met Ala Val Tyr Leu Ala Ser Gly Asn 
        355                 360                 365             


Val Ser Gly Gly Val Cys Asp Gly Cys Gln His Asn Thr Ala Gly Arg 
    370                 375                 380                 


His Cys Glu Leu Cys Arg Pro Phe Phe Tyr Arg Asp Pro Thr Lys Asp 
385                 390                 395                 400 


Leu Arg Asp Pro Ala Val Cys Arg Ser Cys Asp Cys Asp Pro Met Gly 
                405                 410                 415     


Ser Gln Asp Gly Gly Arg Cys Asp Ser His Asp Asp Pro Ala Leu Gly 
            420                 425                 430         


Leu Val Ser Gly Gln Cys Arg Cys Lys Glu His Val Val Gly Thr Arg 
        435                 440                 445             


Cys Gln Gln Cys Arg Asp Gly Phe Phe Gly Leu Ser Ile Ser Asp Arg 
    450                 455                 460                 


Leu Gly Cys Arg Arg Cys Gln Cys Asn Ala Arg Gly Thr Val Pro Gly 
465                 470                 475                 480 


Ser Thr Pro Cys Asp Pro Asn Ser Gly Ser Cys Tyr Cys Lys Arg Leu 
                485                 490                 495     


Val Thr Gly Arg Gly Cys Asp Arg Cys Leu Pro Gly His Trp Gly Leu 
            500                 505                 510         


Ser His Asp Leu Leu Gly Cys Arg Pro Cys Asp Cys Asp Val Gly Gly 
        515                 520                 525             


Ala Leu Asp Pro Gln Cys Asp Glu Gly Thr Gly Gln Cys His Cys Arg 
    530                 535                 540                 


Gln His Met Val Gly Arg Arg Cys Glu Gln Val Gln Pro Gly Tyr Phe 
545                 550                 555                 560 


Arg Pro Phe Leu Asp His Leu Ile Trp Glu Ala Glu Asp Thr Arg Gly 
                565                 570                 575     


Gln Val Leu Asp Val Val Glu Arg Leu Val Thr Pro Gly Glu Thr Pro 
            580                 585                 590         


Ser Trp Thr Gly Ser Gly Phe Val Arg Leu Gln Glu Gly Gln Thr Leu 
        595                 600                 605             


Glu Phe Leu Val Ala Ser Val Pro Lys Ala Met Asp Tyr Asp Leu Leu 
    610                 615                 620                 


Leu Arg Leu Glu Pro Gln Val Pro Glu Gln Trp Ala Glu Leu Glu Leu 
625                 630                 635                 640 


Ile Val Gln Arg Pro Gly Pro Val Pro Ala His Ser Leu Cys Gly His 
                645                 650                 655     


Leu Val Pro Lys Asp Asp Arg Ile Gln Gly Thr Leu Gln Pro His Ala 
            660                 665                 670         


Arg Tyr Leu Ile Phe Pro Asn Pro Val Cys Leu Glu Pro Gly Ile Ser 
        675                 680                 685             


Tyr Lys Leu His Leu Lys Leu Val Arg Thr Gly Gly Ser Ala Gln Pro 
    690                 695                 700                 


Glu Thr Pro Tyr Ser Gly Pro Gly Leu Leu Ile Asp Ser Leu Val Leu 
705                 710                 715                 720 


Leu Pro Arg Val Leu Val Leu Glu Met Phe Ser Gly Gly Asp Ala Ala 
                725                 730                 735     


Ala Leu Glu Arg Gln Ala Thr Phe Glu Arg Tyr Gln Cys His Glu Glu 
            740                 745                 750         


Gly Leu Val Pro Ser Lys Thr Ser Pro Ser Glu Ala Cys Ala Pro Leu 
        755                 760                 765             


Leu Ile Ser Leu Ser Thr Leu Ile Tyr Asn Gly Ala Leu Pro Cys Gln 
    770                 775                 780                 


Cys Asn Pro Gln Gly Ser Leu Ser Ser Glu Cys Asn Pro His Gly Gly 
785                 790                 795                 800 


Gln Cys Leu Cys Lys Pro Gly Val Val Gly Arg Arg Cys Asp Leu Cys 
                805                 810                 815     


Ala Pro Gly Tyr Tyr Gly Phe Gly Pro Thr Gly Cys Gln Ala Cys Gln 
            820                 825                 830         


Cys Ser His Glu Gly Ala Leu Ser Ser Leu Cys Glu Lys Thr Ser Gly 
        835                 840                 845             


Gln Cys Leu Cys Arg Thr Gly Ala Phe Gly Leu Arg Cys Asp Arg Cys 
    850                 855                 860                 


Gln Arg Gly Gln Trp Gly Phe Pro Ser Cys Arg Pro Cys Val Cys Asn 
865                 870                 875                 880 


Gly His Ala Asp Glu Cys Asn Thr His Thr Gly Ala Cys Leu Gly Cys 
                885                 890                 895     


Arg Asp His Thr Gly Gly Glu His Cys Glu Arg Cys Ile Ala Gly Phe 
            900                 905                 910         


His Gly Asp Pro Arg Leu Pro Tyr Gly Gly Gln Cys Arg Pro Cys Pro 
        915                 920                 925             


Cys Pro Glu Gly Pro Gly Ser Gln Arg His Phe Ala Thr Ser Cys His 
    930                 935                 940                 


Gln Asp Glu Tyr Ser Gln Gln Ile Val Cys His Cys Arg Ala Gly Tyr 
945                 950                 955                 960 


Thr Gly Leu Arg Cys Glu Ala Cys Ala Pro Gly His Phe Gly Asp Pro 
                965                 970                 975     


Ser Arg Pro Gly Gly Arg Cys Gln Leu Cys Glu Cys Ser Gly Asn Ile 
            980                 985                 990         


Asp Pro Met Asp Pro Asp Ala Cys  Asp Pro His Thr Gly  Gln Cys Leu 
        995                 1000                 1005             


Arg Cys  Leu His His Thr Glu  Gly Pro His Cys Ala  His Cys Lys 
    1010                 1015                 1020             


Pro Gly  Phe His Gly Gln Ala  Ala Arg Gln Ser Cys  His Arg Cys 
    1025                 1030                 1035             


Thr Cys  Asn Leu Leu Gly Thr  Asn Pro Gln Gln Cys  Pro Ser Pro 
    1040                 1045                 1050             


Asp Gln  Cys His Cys Asp Pro  Ser Ser Gly Gln Cys  Pro Cys Leu 
    1055                 1060                 1065             


Pro Asn  Val Gln Gly Pro Ser  Cys Asp Arg Cys Ala  Pro Asn Phe 
    1070                 1075                 1080             


Trp Asn  Leu Thr Ser Gly His  Gly Cys Gln Pro Cys  Ala Cys His 
    1085                 1090                 1095             


Pro Ser  Arg Ala Arg Gly Pro  Thr Cys Asn Glu Phe  Thr Gly Gln 
    1100                 1105                 1110             


Cys His  Cys Arg Ala Gly Phe  Gly Gly Arg Thr Cys  Ser Glu Cys 
    1115                 1120                 1125             


Gln Glu  Leu His Trp Gly Asp  Pro Gly Leu Gln Cys  His Ala Cys 
    1130                 1135                 1140             


Asp Cys  Asp Ser Arg Gly Ile  Asp Thr Pro Gln Cys  His Arg Phe 
    1145                 1150                 1155             


Thr Gly  His Cys Ser Cys Arg  Pro Gly Val Ser Gly  Val Arg Cys 
    1160                 1165                 1170             


Asp Gln  Cys Ala Arg Gly Phe  Ser Gly Ile Phe Pro  Ala Cys His 
    1175                 1180                 1185             


Pro Cys  His Ala Cys Phe Gly  Asp Trp Asp Arg Val  Val Gln Asp 
    1190                 1195                 1200             


Leu Ala  Ala Arg Thr Gln Arg  Leu Glu Gln Arg Ala  Gln Glu Leu 
    1205                 1210                 1215             


Gln Gln  Thr Gly Val Leu Gly  Ala Phe Glu Ser Ser  Phe Trp His 
    1220                 1225                 1230             


Met Gln  Glu Lys Leu Gly Ile  Val Gln Gly Ile Val  Gly Ala Arg 
    1235                 1240                 1245             


Asn Thr  Ser Ala Ala Ser Thr  Ala Gln Leu Val Glu  Ala Thr Glu 
    1250                 1255                 1260             


Glu Leu  Arg Arg Glu Ile Gly  Glu Ala Thr Glu His  Leu Thr Gln 
    1265                 1270                 1275             


Leu Glu  Ala Asp Leu Thr Asp  Val Gln Asp Glu Asn  Phe Asn Ala 
    1280                 1285                 1290             


Asn His  Ala Leu Ser Gly Leu  Glu Arg Asp Arg Leu  Ala Leu Asn 
    1295                 1300                 1305             


Leu Thr  Leu Arg Gln Leu Asp  Gln His Leu Asp Leu  Leu Lys His 
    1310                 1315                 1320             


Ser Asn  Phe Leu Gly Ala Tyr  Asp Ser Ile Arg His  Ala His Ser 
    1325                 1330                 1335             


Gln Ser  Ala Glu Ala Glu Arg  Arg Ala Asn Thr Ser  Ala Leu Ala 
    1340                 1345                 1350             


Val Pro  Ser Pro Val Ser Asn  Ser Ala Ser Ala Arg  His Arg Thr 
    1355                 1360                 1365             


Glu Ala  Leu Met Asp Ala Gln  Lys Glu Asp Phe Asn  Ser Lys His 
    1370                 1375                 1380             


Met Ala  Asn Gln Arg Ala Leu  Gly Lys Leu Ser Ala  His Thr His 
    1385                 1390                 1395             


Thr Leu  Ser Leu Thr Asp Ile  Asn Glu Leu Val Cys  Gly Ala Pro 
    1400                 1405                 1410             


Gly Asp  Ala Pro Cys Ala Thr  Ser Pro Cys Gly Gly  Ala Gly Cys 
    1415                 1420                 1425             


Arg Asp  Glu Asp Gly Gln Pro  Arg Cys Gly Gly Leu  Ser Cys Asn 
    1430                 1435                 1440             


Gly Ala  Ala Ala Thr Ala Asp  Leu Ala Leu Gly Arg  Ala Arg His 
    1445                 1450                 1455             


Thr Gln  Ala Glu Leu Gln Arg  Ala Leu Ala Glu Gly  Gly Ser Ile 
    1460                 1465                 1470             


Leu Ser  Arg Val Ala Glu Thr  Arg Arg Gln Ala Ser  Glu Ala Gln 
    1475                 1480                 1485             


Gln Arg  Ala Gln Ala Ala Leu  Asp Lys Ala Asn Ala  Ser Arg Gly 
    1490                 1495                 1500             


Gln Val  Glu Gln Ala Asn Gln  Glu Leu Gln Glu Leu  Ile Gln Ser 
    1505                 1510                 1515             


Val Lys  Asp Phe Leu Asn Gln  Glu Gly Ala Asp Pro  Asp Ser Ile 
    1520                 1525                 1530             


Glu Met  Val Ala Thr Arg Val  Leu Glu Leu Ser Ile  Pro Ala Ser 
    1535                 1540                 1545             


Ala Glu  Gln Ile Gln His Leu  Ala Gly Ala Ile Ala  Glu Arg Val 
    1550                 1555                 1560             


Arg Ser  Leu Ala Asp Val Asp  Ala Ile Leu Ala Arg  Thr Val Gly 
    1565                 1570                 1575             


Asp Val  Arg Arg Ala Glu Gln  Leu Leu Gln Asp Ala  Arg Arg Ala 
    1580                 1585                 1590             


Arg Ser  Trp Ala Glu Asp Glu  Lys Gln Lys Ala Glu  Thr Val Gln 
    1595                 1600                 1605             


Ala Ala  Leu Glu Glu Ala Gln  Arg Ala Gln Gly Ile  Ala Gln Gly 
    1610                 1615                 1620             


Ala Ile  Arg Gly Ala Val Ala  Asp Thr Arg Asp Thr  Glu Gln Thr 
    1625                 1630                 1635             


Leu Tyr  Gln Val Gln Glu Arg  Met Ala Gly Ala Glu  Arg Ala Leu 
    1640                 1645                 1650             


Ser Ser  Ala Gly Glu Arg Ala  Arg Gln Leu Asp Ala  Leu Leu Glu 
    1655                 1660                 1665             


Ala Leu  Lys Leu Lys Arg Ala  Gly Asn Ser Leu Ala  Ala Ser Thr 
    1670                 1675                 1680             


Ala Glu  Glu Thr Ala Gly Ser  Ala Gln Gly Arg Ala  Gln Glu Ala 
    1685                 1690                 1695             


Glu Gln  Leu Leu Arg Gly Pro  Leu Gly Asp Gln Tyr  Gln Thr Val 
    1700                 1705                 1710             


Lys Ala  Leu Ala Glu Arg Lys  Ala Gln Gly Val Leu  Ala Ala Gln 
    1715                 1720                 1725             


Ala Arg  Ala Glu Gln Leu Arg  Asp Glu Ala Arg Asp  Leu Leu Gln 
    1730                 1735                 1740             


Ala Ala  Gln Asp Lys Leu Gln  Arg Leu Gln Glu Leu  Glu Gly Thr 
    1745                 1750                 1755             


Tyr Glu  Glu Asn Glu Arg Ala  Leu Glu Ser Lys Ala  Ala Gln Leu 
    1760                 1765                 1770             


Asp Gly  Leu Glu Ala Arg Met  Arg Ser Val Leu Gln  Ala Ile Asn 
    1775                 1780                 1785             


Leu Gln  Val Gln Ile Tyr Asn  Thr Cys Gln 
    1790                 1795             


<210>  7682
<211>  151
<212>  PRT
<213>  Homo Sapiens

<400>  7682

Met Thr Phe Lys Thr Phe Arg Pro Ala Ala Met Leu Val Glu Arg Ser 
1               5                   10                  15      


Ala Asp Phe Gly Arg Thr Trp His Val Tyr Arg Tyr Phe Ser Tyr Asp 
            20                  25                  30          


Cys Gly Ala Asp Phe Pro Gly Val Pro Leu Ala Pro Pro Arg His Trp 
        35                  40                  45              


Asp Asp Val Val Cys Glu Ser Arg Tyr Ser Glu Ile Glu Pro Ser Thr 
    50                  55                  60                  


Glu Gly Glu Val Ile Tyr Arg Val Leu Asp Pro Ala Ile Pro Ile Pro 
65                  70                  75                  80  


Asp Pro Tyr Ser Ser Arg Ile Gln Asn Leu Leu Lys Ile Thr Asn Leu 
                85                  90                  95      


Arg Val Asn Leu Thr Arg Leu His Thr Leu Gly Asp Asn Leu Leu Asp 
            100                 105                 110         


Pro Arg Arg Glu Ile Arg Glu Lys Tyr Tyr Tyr Ala Leu Tyr Glu Leu 
        115                 120                 125             


Val Val Arg Gly Asn Cys Phe Cys Tyr Gly His Ala Ser Glu Cys Ala 
    130                 135                 140                 


Pro Ala Pro Gly Ala Pro Ala 
145                 150     


<210>  7683
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  7683

Met Asn Glu Ile Gln Ala Ile Ala Ala Arg Leu Pro Asn Val Asp Leu 
1               5                   10                  15      


Val Leu Ser Gln Thr Lys Gln Asp Ile Ala Arg Ala Arg Arg Leu Gln 
            20                  25                  30          


Ala Glu Ala Glu Glu Ala Arg Ser Arg Ala His Ala Val Glu Gly Gln 
        35                  40                  45              


Val Glu Asp Val Val Gly Asn Leu Arg Gln Gly Thr Val Ala Leu Gln 
    50                  55                  60                  


Glu Ala Gln Asp Thr Met Gln Gly Thr Ser Arg Ser Leu Arg Leu Ile 
65                  70                  75                  80  


Gln Asp Arg Val Ala Glu Val Gln Gln Val Leu Arg Pro Ala Glu Lys 
                85                  90                  95      


Leu Val Thr Ser Met Thr Lys Gln Leu Gly Asp Phe Trp Thr Arg Met 
            100                 105                 110         


Glu Glu Leu Arg His Gln Ala Arg Gln Gln Gly Ala Glu Ala Val Gln 
        115                 120                 125             


Ala Gln Gln Leu Ala Glu Gly Ala Ser Glu Gln Ala Leu Ser Ala Gln 
    130                 135                 140                 


Glu Gly Phe Glu Arg Ile Lys Gln Lys Tyr Ala Glu Leu Lys Asp Arg 
145                 150                 155                 160 


<210>  7684
<211>  188
<212>  PRT
<213>  Homo Sapiens

<400>  7684

Met Arg Pro Phe Phe Leu Leu Cys Phe Ala Leu Pro Gly Leu Leu His 
1               5                   10                  15      


Ala Gln Gln Ala Cys Ser Arg Gly Ala Cys Tyr Pro Pro Val Gly Asp 
            20                  25                  30          


Leu Leu Val Gly Arg Thr Arg Phe Leu Arg Ala Ser Ser Thr Cys Gly 
        35                  40                  45              


Leu Thr Lys Pro Glu Thr Tyr Cys Thr Gln Tyr Gly Glu Trp Gln Met 
    50                  55                  60                  


Lys Cys Cys Lys Cys Asp Ser Arg Gln Pro His Asn Tyr Tyr Ser His 
65                  70                  75                  80  


Arg Val Glu Asn Val Ala Ser Ser Ser Gly Pro Met Arg Trp Trp Gln 
                85                  90                  95      


Ser Gln Asn Asp Val Asn Pro Val Ser Leu Gln Leu Asp Leu Asp Arg 
            100                 105                 110         


Arg Phe Gln Leu Gln Glu Val Met Met Glu Phe Gln Gly Pro Met Pro 
        115                 120                 125             


Ala Gly Met Leu Ile Glu Arg Ser Ser Asp Phe Gly Lys Thr Trp Arg 
    130                 135                 140                 


Val Tyr Gln Tyr Leu Ala Ala Asp Cys Thr Ser Thr Phe Pro Arg Val 
145                 150                 155                 160 


Arg Gln Gly Arg Pro Gln Ser Trp Gln Asp Val Arg Cys Gln Ser Leu 
                165                 170                 175     


Pro Gln Arg Pro Asn Ala Arg Leu Asn Gly Gly Lys 
            180                 185             


<210>  7685
<211>  1172
<212>  PRT
<213>  Homo Sapiens

<400>  7685

Met Arg Pro Phe Phe Leu Leu Cys Phe Ala Leu Pro Gly Leu Leu His 
1               5                   10                  15      


Ala Gln Gln Ala Cys Ser Arg Gly Ala Cys Tyr Pro Pro Val Gly Asp 
            20                  25                  30          


Leu Leu Val Gly Arg Thr Arg Phe Leu Arg Ala Ser Ser Thr Cys Gly 
        35                  40                  45              


Leu Thr Lys Pro Glu Thr Tyr Cys Thr Gln Tyr Gly Glu Trp Gln Met 
    50                  55                  60                  


Lys Cys Cys Lys Cys Asp Ser Arg Gln Pro His Asn Tyr Tyr Ser His 
65                  70                  75                  80  


Arg Val Glu Asn Val Ala Ser Ser Ser Gly Pro Met Arg Trp Trp Gln 
                85                  90                  95      


Ser Gln Asn Asp Val Asn Pro Val Ser Leu Gln Leu Asp Leu Asp Arg 
            100                 105                 110         


Arg Phe Gln Leu Gln Glu Val Met Met Glu Phe Gln Gly Pro Met Pro 
        115                 120                 125             


Ala Gly Met Leu Ile Glu Arg Ser Ser Asp Phe Gly Lys Thr Trp Arg 
    130                 135                 140                 


Val Tyr Gln Tyr Leu Ala Ala Asp Cys Thr Ser Thr Phe Pro Arg Val 
145                 150                 155                 160 


Arg Gln Gly Arg Pro Gln Ser Trp Gln Asp Val Arg Cys Gln Ser Leu 
                165                 170                 175     


Pro Gln Arg Pro Asn Ala Arg Leu Asn Gly Gly Lys Val Gln Leu Asn 
            180                 185                 190         


Leu Met Asp Leu Val Ser Gly Ile Pro Ala Thr Gln Ser Gln Lys Ile 
        195                 200                 205             


Gln Glu Val Gly Glu Ile Thr Asn Leu Arg Val Asn Phe Thr Arg Leu 
    210                 215                 220                 


Ala Pro Val Pro Gln Arg Gly Tyr His Pro Pro Ser Ala Tyr Tyr Ala 
225                 230                 235                 240 


Val Ser Gln Leu Arg Leu Gln Gly Ser Cys Phe Cys His Gly His Ala 
                245                 250                 255     


Asp Arg Cys Ala Pro Lys Pro Gly Ala Ser Ala Gly Pro Ser Thr Ala 
            260                 265                 270         


Val Gln Val His Asp Val Cys Val Cys Gln His Asn Thr Ala Gly Pro 
        275                 280                 285             


Asn Cys Glu Arg Cys Ala Pro Phe Tyr Asn Asn Arg Pro Trp Arg Pro 
    290                 295                 300                 


Ala Glu Gly Gln Asp Ala His Glu Cys Gln Arg Cys Asp Cys Asn Gly 
305                 310                 315                 320 


His Ser Glu Thr Cys His Phe Asp Pro Ala Val Phe Ala Ala Ser Gln 
                325                 330                 335     


Gly Ala Tyr Gly Gly Val Cys Asp Asn Cys Arg Asp His Thr Glu Gly 
            340                 345                 350         


Lys Asn Cys Glu Arg Cys Gln Leu His Tyr Phe Arg Asn Arg Arg Pro 
        355                 360                 365             


Gly Ala Ser Ile Gln Glu Thr Cys Ile Ser Cys Glu Cys Asp Pro Asp 
    370                 375                 380                 


Gly Ala Val Pro Gly Ala Pro Cys Asp Pro Val Thr Gly Gln Cys Val 
385                 390                 395                 400 


Cys Lys Glu His Val Gln Gly Glu Arg Cys Asp Leu Cys Lys Pro Gly 
                405                 410                 415     


Phe Thr Gly Leu Thr Tyr Ala Asn Pro Gln Gly Cys His Arg Cys Asp 
            420                 425                 430         


Cys Asn Ile Leu Gly Ser Arg Arg Asp Met Pro Cys Asp Glu Glu Ser 
        435                 440                 445             


Gly Arg Cys Leu Cys Leu Pro Asn Val Val Gly Pro Lys Cys Asp Gln 
    450                 455                 460                 


Cys Ala Pro Tyr His Trp Lys Leu Ala Ser Gly Gln Gly Cys Glu Pro 
465                 470                 475                 480 


Cys Ala Cys Asp Pro His Asn Ser Leu Ser Pro Gln Cys Asn Gln Phe 
                485                 490                 495     


Thr Gly Gln Cys Pro Cys Arg Glu Gly Phe Gly Gly Leu Met Cys Ser 
            500                 505                 510         


Ala Ala Ala Ile Arg Gln Cys Pro Asp Arg Thr Tyr Gly Asp Val Ala 
        515                 520                 525             


Thr Gly Cys Arg Ala Cys Asp Cys Asp Phe Arg Gly Thr Glu Gly Pro 
    530                 535                 540                 


Gly Cys Asp Lys Ala Ser Gly Arg Cys Leu Cys Arg Pro Gly Leu Thr 
545                 550                 555                 560 


Gly Pro Arg Cys Asp Gln Cys Gln Arg Gly Tyr Cys Asn Arg Tyr Pro 
                565                 570                 575     


Val Cys Val Ala Cys His Pro Cys Phe Gln Thr Tyr Asp Ala Asp Leu 
            580                 585                 590         


Arg Glu Gln Ala Leu Arg Phe Gly Arg Leu Arg Asn Ala Thr Ala Ser 
        595                 600                 605             


Leu Trp Ser Gly Pro Gly Leu Glu Asp Arg Gly Leu Ala Ser Arg Ile 
    610                 615                 620                 


Leu Asp Ala Lys Ser Lys Ile Glu Gln Ile Arg Ala Val Leu Ser Ser 
625                 630                 635                 640 


Pro Ala Val Thr Glu Gln Glu Val Ala Gln Val Ala Ser Ala Ile Leu 
                645                 650                 655     


Ser Leu Arg Arg Thr Leu Gln Gly Leu Gln Leu Asp Leu Pro Leu Glu 
            660                 665                 670         


Glu Glu Thr Leu Ser Leu Pro Arg Asp Leu Glu Ser Leu Asp Arg Ser 
        675                 680                 685             


Phe Asn Gly Leu Leu Thr Met Tyr Gln Arg Lys Arg Glu Gln Phe Glu 
    690                 695                 700                 


Lys Ile Ser Ser Ala Asp Pro Ser Gly Ala Phe Arg Met Leu Ser Thr 
705                 710                 715                 720 


Ala Tyr Glu Gln Ser Ala Gln Ala Ala Gln Gln Val Ser Asp Ser Ser 
                725                 730                 735     


Arg Leu Leu Asp Gln Leu Arg Asp Ser Arg Arg Glu Ala Glu Arg Leu 
            740                 745                 750         


Val Arg Gln Ala Gly Gly Gly Gly Gly Thr Gly Ser Pro Lys Leu Val 
        755                 760                 765             


Ala Leu Arg Leu Glu Met Ser Ser Leu Pro Asp Leu Thr Pro Thr Phe 
    770                 775                 780                 


Asn Lys Leu Cys Gly Asn Ser Arg Gln Met Ala Cys Thr Pro Ile Ser 
785                 790                 795                 800 


Cys Pro Gly Glu Leu Cys Pro Gln Asp Asn Gly Thr Ala Cys Gly Ser 
                805                 810                 815     


Arg Cys Arg Gly Val Leu Pro Arg Ala Gly Gly Ala Phe Leu Met Ala 
            820                 825                 830         


Gly Gln Val Ala Glu Gln Leu Arg Gly Phe Asn Ala Gln Leu Gln Arg 
        835                 840                 845             


Thr Arg Gln Met Ile Arg Ala Ala Glu Glu Ser Ala Ser Gln Ile Gln 
    850                 855                 860                 


Ser Ser Ala Gln Arg Leu Glu Thr Gln Val Ser Ala Ser Arg Ser Gln 
865                 870                 875                 880 


Met Glu Glu Asp Val Arg Arg Thr Arg Leu Leu Ile Gln Gln Val Arg 
                885                 890                 895     


Asp Phe Leu Thr Asp Pro Asp Thr Asp Ala Ala Thr Ile Gln Glu Val 
            900                 905                 910         


Ser Glu Ala Val Leu Ala Leu Trp Leu Pro Thr Asp Ser Ala Thr Val 
        915                 920                 925             


Leu Gln Lys Met Asn Glu Ile Gln Ala Ile Ala Ala Arg Leu Pro Asn 
    930                 935                 940                 


Val Asp Leu Val Leu Ser Gln Thr Lys Gln Asp Ile Ala Arg Ala Arg 
945                 950                 955                 960 


Arg Leu Gln Ala Glu Ala Glu Glu Ala Arg Ser Arg Ala His Ala Val 
                965                 970                 975     


Glu Gly Gln Val Glu Asp Val Val Gly Asn Leu Arg Gln Gly Thr Val 
            980                 985                 990         


Ala Leu Gln Glu Ala Gln Asp Thr  Met Gln Gly Thr Ser  Arg Ser Leu 
        995                 1000                 1005             


Arg Leu  Ile Gln Asp Arg Val  Ala Glu Val Gln Gln  Val Leu Arg 
    1010                 1015                 1020             


Pro Ala  Glu Lys Leu Val Thr  Ser Met Thr Lys Gln  Leu Gly Asp 
    1025                 1030                 1035             


Phe Trp  Thr Arg Met Glu Glu  Leu Arg His Gln Ala  Arg Gln Gln 
    1040                 1045                 1050             


Gly Ala  Glu Ala Val Gln Ala  Gln Gln Leu Ala Glu  Gly Ala Ser 
    1055                 1060                 1065             


Glu Gln  Ala Leu Ser Ala Gln  Glu Gly Phe Glu Arg  Ile Lys Gln 
    1070                 1075                 1080             


Lys Tyr  Ala Glu Leu Lys Asp  Arg Leu Gly Gln Ser  Ser Met Leu 
    1085                 1090                 1095             


Gly Glu  Gln Gly Ala Arg Ile  Gln Ser Val Lys Thr  Glu Ala Glu 
    1100                 1105                 1110             


Glu Leu  Phe Gly Glu Thr Met  Glu Met Met Asp Arg  Met Lys Asp 
    1115                 1120                 1125             


Met Glu  Leu Glu Leu Leu Arg  Gly Ser Gln Ala Ile  Met Leu Arg 
    1130                 1135                 1140             


Ser Ala  Asp Leu Thr Gly Leu  Glu Lys Arg Val Glu  Gln Ile Arg 
    1145                 1150                 1155             


Asp His  Ile Asn Gly Arg Val  Leu Tyr Tyr Ala Thr  Cys Lys 
    1160                 1165                 1170         


<210>  7686
<211>  1172
<212>  PRT
<213>  Homo Sapiens

<400>  7686

Met Arg Pro Phe Phe Leu Leu Cys Phe Ala Leu Pro Gly Leu Leu His 
1               5                   10                  15      


Ala Gln Gln Ala Cys Ser Arg Gly Ala Cys Tyr Pro Pro Val Gly Asp 
            20                  25                  30          


Leu Leu Val Gly Arg Thr Arg Phe Leu Arg Ala Ser Ser Thr Cys Gly 
        35                  40                  45              


Leu Thr Lys Pro Glu Thr Tyr Cys Thr Gln Tyr Gly Glu Trp Gln Met 
    50                  55                  60                  


Lys Cys Cys Lys Cys Asp Ser Arg Gln Pro His Asn Tyr Tyr Ser His 
65                  70                  75                  80  


Arg Val Glu Asn Val Ala Ser Ser Ser Gly Pro Met Arg Trp Trp Gln 
                85                  90                  95      


Ser Gln Asn Asp Val Asn Pro Val Ser Leu Gln Leu Asp Leu Asp Arg 
            100                 105                 110         


Arg Phe Gln Leu Gln Glu Val Met Met Glu Phe Gln Gly Pro Met Pro 
        115                 120                 125             


Ala Gly Met Leu Ile Glu Arg Ser Ser Asp Phe Gly Lys Thr Trp Arg 
    130                 135                 140                 


Val Tyr Gln Tyr Leu Ala Ala Asp Cys Thr Ser Thr Phe Pro Arg Val 
145                 150                 155                 160 


Arg Gln Gly Arg Pro Gln Ser Trp Gln Asp Val Arg Cys Gln Ser Leu 
                165                 170                 175     


Pro Gln Arg Pro Asn Ala Arg Leu Asn Gly Gly Lys Val Gln Leu Asn 
            180                 185                 190         


Leu Met Asp Leu Val Ser Gly Ile Pro Ala Thr Gln Ser Gln Lys Ile 
        195                 200                 205             


Gln Glu Val Gly Glu Ile Thr Asn Leu Arg Val Asn Phe Thr Arg Leu 
    210                 215                 220                 


Ala Pro Val Pro Gln Arg Gly Tyr His Pro Pro Ser Ala Tyr Tyr Ala 
225                 230                 235                 240 


Val Ser Gln Leu Arg Leu Gln Gly Ser Cys Phe Cys His Gly His Ala 
                245                 250                 255     


Asp Arg Cys Ala Pro Lys Pro Gly Ala Ser Ala Gly Pro Ser Thr Ala 
            260                 265                 270         


Val Gln Val His Asp Val Cys Val Cys Gln His Asn Thr Ala Gly Pro 
        275                 280                 285             


Asn Cys Glu Arg Cys Ala Pro Phe Tyr Asn Asn Arg Pro Trp Arg Pro 
    290                 295                 300                 


Ala Glu Gly Gln Asp Ala His Glu Cys Gln Arg Cys Asp Cys Asn Gly 
305                 310                 315                 320 


His Ser Glu Thr Cys His Phe Asp Pro Ala Val Phe Ala Ala Ser Gln 
                325                 330                 335     


Gly Ala Tyr Gly Gly Val Cys Asp Asn Cys Arg Asp His Thr Glu Gly 
            340                 345                 350         


Lys Asn Cys Glu Arg Cys Gln Leu His Tyr Phe Arg Asn Arg Arg Pro 
        355                 360                 365             


Gly Ala Ser Ile Gln Glu Thr Cys Ile Ser Cys Glu Cys Asp Pro Asp 
    370                 375                 380                 


Gly Ala Val Pro Gly Ala Pro Cys Asp Pro Val Thr Gly Gln Cys Val 
385                 390                 395                 400 


Cys Lys Glu His Val Gln Gly Glu Arg Cys Asp Leu Cys Lys Pro Gly 
                405                 410                 415     


Phe Thr Gly Leu Thr Tyr Ala Asn Pro Gln Gly Cys His Arg Cys Asp 
            420                 425                 430         


Cys Asn Ile Leu Gly Ser Arg Arg Asp Met Pro Cys Asp Glu Glu Ser 
        435                 440                 445             


Gly Arg Cys Leu Cys Leu Pro Asn Val Val Gly Pro Lys Cys Asp Gln 
    450                 455                 460                 


Cys Ala Pro Tyr His Trp Lys Leu Ala Ser Gly Gln Gly Cys Glu Pro 
465                 470                 475                 480 


Cys Ala Cys Asp Pro His Asn Ser Leu Ser Pro Gln Cys Asn Gln Phe 
                485                 490                 495     


Thr Gly Gln Cys Pro Cys Arg Glu Gly Phe Gly Gly Leu Met Cys Ser 
            500                 505                 510         


Ala Ala Ala Ile Arg Gln Cys Pro Asp Arg Thr Tyr Gly Asp Val Ala 
        515                 520                 525             


Thr Gly Cys Arg Ala Cys Asp Cys Asp Phe Arg Gly Thr Glu Gly Pro 
    530                 535                 540                 


Gly Cys Asp Lys Ala Ser Gly Arg Cys Leu Cys Arg Pro Gly Leu Thr 
545                 550                 555                 560 


Gly Pro Arg Cys Asp Gln Cys Gln Arg Gly Tyr Cys Asn Arg Tyr Pro 
                565                 570                 575     


Val Cys Val Ala Cys His Pro Cys Phe Gln Thr Tyr Asp Ala Asp Leu 
            580                 585                 590         


Arg Glu Gln Ala Leu Arg Phe Gly Arg Leu Arg Asn Ala Thr Ala Ser 
        595                 600                 605             


Leu Trp Ser Gly Pro Gly Leu Glu Asp Arg Gly Leu Ala Ser Arg Ile 
    610                 615                 620                 


Leu Asp Ala Lys Ser Lys Ile Glu Gln Ile Arg Ala Val Leu Ser Ser 
625                 630                 635                 640 


Pro Ala Val Thr Glu Gln Glu Val Ala Gln Val Ala Ser Ala Ile Leu 
                645                 650                 655     


Ser Leu Arg Arg Thr Leu Gln Gly Leu Gln Leu Asp Leu Pro Leu Glu 
            660                 665                 670         


Glu Glu Thr Leu Ser Leu Pro Arg Asp Leu Glu Ser Leu Asp Arg Ser 
        675                 680                 685             


Phe Asn Gly Leu Leu Thr Met Tyr Gln Arg Lys Arg Glu Gln Phe Glu 
    690                 695                 700                 


Lys Ile Ser Ser Ala Asp Pro Ser Gly Ala Phe Arg Met Leu Ser Thr 
705                 710                 715                 720 


Ala Tyr Glu Gln Ser Ala Gln Ala Ala Gln Gln Val Ser Asp Ser Ser 
                725                 730                 735     


Arg Leu Leu Asp Gln Leu Arg Asp Ser Arg Arg Glu Ala Glu Arg Leu 
            740                 745                 750         


Val Arg Gln Ala Gly Gly Gly Gly Gly Thr Gly Ser Pro Lys Leu Val 
        755                 760                 765             


Ala Leu Arg Leu Glu Met Ser Ser Leu Pro Asp Leu Thr Pro Thr Phe 
    770                 775                 780                 


Asn Lys Leu Cys Gly Asn Ser Arg Gln Met Ala Cys Thr Pro Ile Ser 
785                 790                 795                 800 


Cys Pro Gly Glu Leu Cys Pro Gln Asp Asn Gly Thr Ala Cys Gly Ser 
                805                 810                 815     


Arg Cys Arg Gly Val Leu Pro Arg Ala Gly Gly Ala Phe Leu Met Ala 
            820                 825                 830         


Gly Gln Val Ala Glu Gln Leu Arg Gly Phe Asn Ala Gln Leu Gln Arg 
        835                 840                 845             


Thr Arg Gln Met Ile Arg Ala Ala Glu Glu Ser Ala Ser Gln Ile Gln 
    850                 855                 860                 


Ser Ser Ala Gln Arg Leu Glu Thr Gln Val Ser Ala Ser Arg Ser Gln 
865                 870                 875                 880 


Met Glu Glu Asp Val Arg Arg Thr Arg Leu Leu Ile Gln Gln Val Arg 
                885                 890                 895     


Asp Phe Leu Thr Asp Pro Asp Thr Asp Ala Ala Thr Ile Gln Glu Val 
            900                 905                 910         


Ser Glu Ala Val Leu Ala Leu Trp Leu Pro Thr Asp Ser Ala Thr Val 
        915                 920                 925             


Leu Gln Lys Met Asn Glu Ile Gln Ala Ile Ala Ala Arg Leu Pro Asn 
    930                 935                 940                 


Val Asp Leu Val Leu Ser Gln Thr Lys Gln Asp Ile Ala Arg Ala Arg 
945                 950                 955                 960 


Arg Leu Gln Ala Glu Ala Glu Glu Ala Arg Ser Arg Ala His Ala Val 
                965                 970                 975     


Glu Gly Gln Val Glu Asp Val Val Gly Asn Leu Arg Gln Gly Thr Val 
            980                 985                 990         


Ala Leu Gln Glu Ala Gln Asp Thr  Met Gln Gly Thr Ser  Arg Ser Leu 
        995                 1000                 1005             


Arg Leu  Ile Gln Asp Arg Val  Ala Glu Val Gln Gln  Val Leu Arg 
    1010                 1015                 1020             


Pro Ala  Glu Lys Leu Val Thr  Ser Met Thr Lys Gln  Leu Gly Asp 
    1025                 1030                 1035             


Phe Trp  Thr Arg Met Glu Glu  Leu Arg His Gln Ala  Arg Gln Gln 
    1040                 1045                 1050             


Gly Ala  Glu Ala Val Gln Ala  Gln Gln Leu Ala Glu  Gly Ala Ser 
    1055                 1060                 1065             


Glu Gln  Ala Leu Ser Ala Gln  Glu Gly Phe Glu Arg  Ile Lys Gln 
    1070                 1075                 1080             


Lys Tyr  Ala Glu Leu Lys Asp  Arg Leu Gly Gln Ser  Ser Met Leu 
    1085                 1090                 1095             


Gly Glu  Gln Gly Ala Arg Ile  Gln Ser Val Lys Thr  Glu Ala Glu 
    1100                 1105                 1110             


Glu Leu  Phe Gly Glu Thr Met  Glu Met Met Asp Arg  Met Lys Asp 
    1115                 1120                 1125             


Met Glu  Leu Glu Leu Leu Arg  Gly Ser Gln Ala Ile  Met Leu Arg 
    1130                 1135                 1140             


Ser Ala  Asp Leu Thr Gly Leu  Glu Lys Arg Val Glu  Gln Ile Arg 
    1145                 1150                 1155             


Asp His  Ile Asn Gly Arg Val  Leu Tyr Tyr Ala Thr  Cys Lys 
    1160                 1165                 1170         


<210>  7687
<211>  1172
<212>  PRT
<213>  Homo Sapiens

<400>  7687

Met Arg Pro Phe Phe Leu Leu Cys Phe Ala Leu Pro Gly Leu Leu His 
1               5                   10                  15      


Ala Gln Gln Ala Cys Ser Arg Gly Ala Cys Tyr Pro Pro Val Gly Asp 
            20                  25                  30          


Leu Leu Val Gly Arg Thr Arg Phe Leu Arg Ala Ser Ser Thr Cys Gly 
        35                  40                  45              


Leu Thr Lys Pro Glu Thr Tyr Cys Thr Gln Tyr Gly Glu Trp Gln Met 
    50                  55                  60                  


Lys Cys Cys Lys Cys Asp Ser Arg Gln Pro His Asn Tyr Tyr Ser His 
65                  70                  75                  80  


Arg Val Glu Asn Val Ala Ser Ser Ser Gly Pro Met Arg Trp Trp Gln 
                85                  90                  95      


Ser Gln Asn Asp Val Asn Pro Val Ser Leu Gln Leu Asp Leu Asp Arg 
            100                 105                 110         


Arg Phe Gln Leu Gln Glu Val Met Met Glu Phe Gln Gly Pro Met Pro 
        115                 120                 125             


Ala Gly Met Leu Ile Glu Arg Ser Ser Asp Phe Gly Lys Thr Trp Arg 
    130                 135                 140                 


Val Tyr Gln Tyr Leu Ala Ala Asp Cys Thr Ser Thr Phe Pro Arg Val 
145                 150                 155                 160 


Arg Gln Gly Arg Pro Gln Ser Trp Gln Asp Val Arg Cys Gln Ser Leu 
                165                 170                 175     


Pro Gln Arg Pro Asn Ala Arg Leu Asn Gly Gly Lys Val Gln Leu Asn 
            180                 185                 190         


Leu Met Asp Leu Val Ser Gly Ile Pro Ala Thr Gln Ser Gln Lys Ile 
        195                 200                 205             


Gln Glu Val Gly Glu Ile Thr Asn Leu Arg Val Asn Phe Thr Arg Leu 
    210                 215                 220                 


Ala Pro Val Pro Gln Arg Gly Tyr His Pro Pro Ser Ala Tyr Tyr Ala 
225                 230                 235                 240 


Val Ser Gln Leu Arg Leu Gln Gly Ser Cys Phe Cys His Gly His Ala 
                245                 250                 255     


Asp Arg Cys Ala Pro Lys Pro Gly Ala Ser Ala Gly Pro Ser Thr Ala 
            260                 265                 270         


Val Gln Val His Asp Val Cys Val Cys Gln His Asn Thr Ala Gly Pro 
        275                 280                 285             


Asn Cys Glu Arg Cys Ala Pro Phe Tyr Asn Asn Arg Pro Trp Arg Pro 
    290                 295                 300                 


Ala Glu Gly Gln Asp Ala His Glu Cys Gln Arg Cys Asp Cys Asn Gly 
305                 310                 315                 320 


His Ser Glu Thr Cys His Phe Asp Pro Ala Val Phe Ala Ala Ser Gln 
                325                 330                 335     


Gly Ala Tyr Gly Gly Val Cys Asp Asn Cys Arg Asp His Thr Glu Gly 
            340                 345                 350         


Lys Asn Cys Glu Arg Cys Gln Leu His Tyr Phe Arg Asn Arg Arg Pro 
        355                 360                 365             


Gly Ala Ser Ile Gln Glu Thr Cys Ile Ser Cys Glu Cys Asp Pro Asp 
    370                 375                 380                 


Gly Ala Val Pro Gly Ala Pro Cys Asp Pro Val Thr Gly Gln Cys Val 
385                 390                 395                 400 


Cys Lys Glu His Val Gln Gly Glu Arg Cys Asp Leu Cys Lys Pro Gly 
                405                 410                 415     


Phe Thr Gly Leu Thr Tyr Ala Asn Pro Gln Gly Cys His Arg Cys Asp 
            420                 425                 430         


Cys Asn Ile Leu Gly Ser Arg Arg Asp Met Pro Cys Asp Glu Glu Ser 
        435                 440                 445             


Gly Arg Cys Leu Cys Leu Pro Asn Val Val Gly Pro Lys Cys Asp Gln 
    450                 455                 460                 


Cys Ala Pro Tyr His Trp Lys Leu Ala Ser Gly Gln Gly Cys Glu Pro 
465                 470                 475                 480 


Cys Ala Cys Asp Pro His Asn Ser Leu Ser Pro Gln Cys Asn Gln Phe 
                485                 490                 495     


Thr Gly Gln Cys Pro Cys Arg Glu Gly Phe Gly Gly Leu Met Cys Ser 
            500                 505                 510         


Ala Ala Ala Ile Arg Gln Cys Pro Asp Arg Thr Tyr Gly Asp Val Ala 
        515                 520                 525             


Thr Gly Cys Arg Ala Cys Asp Cys Asp Phe Arg Gly Thr Glu Gly Pro 
    530                 535                 540                 


Gly Cys Asp Lys Ala Ser Gly Arg Cys Leu Cys Arg Pro Gly Leu Thr 
545                 550                 555                 560 


Gly Pro Arg Cys Asp Gln Cys Gln Arg Gly Tyr Cys Asn Arg Tyr Pro 
                565                 570                 575     


Val Cys Val Ala Cys His Pro Cys Phe Gln Thr Tyr Asp Ala Asp Leu 
            580                 585                 590         


Arg Glu Gln Ala Leu Arg Phe Gly Arg Leu Arg Asn Ala Thr Ala Ser 
        595                 600                 605             


Leu Trp Ser Gly Pro Gly Leu Glu Asp Arg Gly Leu Ala Ser Arg Ile 
    610                 615                 620                 


Leu Asp Ala Lys Ser Lys Ile Glu Gln Ile Arg Ala Val Leu Ser Ser 
625                 630                 635                 640 


Pro Ala Val Thr Glu Gln Glu Val Ala Gln Val Ala Ser Ala Ile Leu 
                645                 650                 655     


Ser Leu Arg Arg Thr Leu Gln Gly Leu Gln Leu Asp Leu Pro Leu Glu 
            660                 665                 670         


Glu Glu Thr Leu Ser Leu Pro Arg Asp Leu Glu Ser Leu Asp Arg Ser 
        675                 680                 685             


Phe Asn Gly Leu Leu Thr Met Tyr Gln Arg Lys Arg Glu Gln Phe Glu 
    690                 695                 700                 


Lys Ile Ser Ser Ala Asp Pro Ser Gly Ala Phe Arg Met Leu Ser Thr 
705                 710                 715                 720 


Ala Tyr Glu Gln Ser Ala Gln Ala Ala Gln Gln Val Ser Asp Ser Ser 
                725                 730                 735     


Arg Leu Leu Asp Gln Leu Arg Asp Ser Arg Arg Glu Ala Glu Arg Leu 
            740                 745                 750         


Val Arg Gln Ala Gly Gly Gly Gly Gly Thr Gly Ser Pro Lys Leu Val 
        755                 760                 765             


Ala Leu Arg Leu Glu Met Ser Ser Leu Pro Asp Leu Thr Pro Thr Phe 
    770                 775                 780                 


Asn Lys Leu Cys Gly Asn Ser Arg Gln Met Ala Cys Thr Pro Ile Ser 
785                 790                 795                 800 


Cys Pro Gly Glu Leu Cys Pro Gln Asp Asn Gly Thr Ala Cys Gly Ser 
                805                 810                 815     


Arg Cys Arg Gly Val Leu Pro Arg Ala Gly Gly Ala Phe Leu Met Ala 
            820                 825                 830         


Gly Gln Val Ala Glu Gln Leu Arg Gly Phe Asn Ala Gln Leu Gln Arg 
        835                 840                 845             


Thr Arg Gln Met Ile Arg Ala Ala Glu Glu Ser Ala Ser Gln Ile Gln 
    850                 855                 860                 


Ser Ser Ala Gln Arg Leu Glu Thr Gln Val Ser Ala Ser Arg Ser Gln 
865                 870                 875                 880 


Met Glu Glu Asp Val Arg Arg Thr Arg Leu Leu Ile Gln Gln Val Arg 
                885                 890                 895     


Asp Phe Leu Thr Asp Pro Asp Thr Asp Ala Ala Thr Ile Gln Glu Val 
            900                 905                 910         


Ser Glu Ala Val Leu Ala Leu Trp Leu Pro Thr Asp Ser Ala Thr Val 
        915                 920                 925             


Leu Gln Lys Met Asn Glu Ile Gln Ala Ile Ala Ala Arg Leu Pro Asn 
    930                 935                 940                 


Val Asp Leu Val Leu Ser Gln Thr Lys Gln Asp Ile Ala Arg Ala Arg 
945                 950                 955                 960 


Arg Leu Gln Ala Glu Ala Glu Glu Ala Arg Ser Arg Ala His Ala Val 
                965                 970                 975     


Glu Gly Gln Val Glu Asp Val Val Gly Asn Leu Arg Gln Gly Thr Val 
            980                 985                 990         


Ala Leu Gln Glu Ala Gln Asp Thr  Met Gln Gly Thr Ser  Arg Ser Leu 
        995                 1000                 1005             


Arg Leu  Ile Gln Asp Arg Val  Ala Glu Val Gln Gln  Val Leu Arg 
    1010                 1015                 1020             


Pro Ala  Glu Lys Leu Val Thr  Ser Met Thr Lys Gln  Leu Gly Asp 
    1025                 1030                 1035             


Phe Trp  Thr Arg Met Glu Glu  Leu Arg His Gln Ala  Arg Gln Gln 
    1040                 1045                 1050             


Gly Ala  Glu Ala Val Gln Ala  Gln Gln Leu Ala Glu  Gly Ala Ser 
    1055                 1060                 1065             


Glu Gln  Ala Leu Ser Ala Gln  Glu Gly Phe Glu Arg  Ile Lys Gln 
    1070                 1075                 1080             


Lys Tyr  Ala Glu Leu Lys Asp  Arg Leu Gly Gln Ser  Ser Met Leu 
    1085                 1090                 1095             


Gly Glu  Gln Gly Ala Arg Ile  Gln Ser Val Lys Thr  Glu Ala Glu 
    1100                 1105                 1110             


Glu Leu  Phe Gly Glu Thr Met  Glu Met Met Asp Arg  Met Lys Asp 
    1115                 1120                 1125             


Met Glu  Leu Glu Leu Leu Arg  Gly Ser Gln Ala Ile  Met Leu Arg 
    1130                 1135                 1140             


Ser Ala  Asp Leu Thr Gly Leu  Glu Lys Arg Val Glu  Gln Ile Arg 
    1145                 1150                 1155             


Asp His  Ile Asn Gly Arg Val  Leu Tyr Tyr Ala Thr  Cys Lys 
    1160                 1165                 1170         


<210>  7688
<211>  1761
<212>  PRT
<213>  Homo Sapiens

<400>  7688

Met Gln Phe Gln Leu Thr Leu Phe Leu His Leu Gly Trp Leu Ser Tyr 
1               5                   10                  15      


Ser Lys Ala Gln Asp Asp Cys Asn Arg Gly Ala Cys His Pro Thr Thr 
            20                  25                  30          


Gly Asp Leu Leu Val Gly Arg Asn Thr Gln Leu Met Ala Ser Ser Thr 
        35                  40                  45              


Cys Gly Leu Ser Arg Ala Gln Lys Tyr Cys Ile Leu Ser Tyr Leu Glu 
    50                  55                  60                  


Gly Glu Gln Lys Cys Phe Ile Cys Asp Ser Arg Phe Pro Tyr Asp Pro 
65                  70                  75                  80  


Tyr Asp Gln Pro Asn Ser His Thr Ile Glu Asn Val Ile Val Ser Phe 
                85                  90                  95      


Glu Pro Asp Arg Glu Lys Lys Trp Trp Gln Ser Glu Asn Gly Leu Asp 
            100                 105                 110         


His Val Ser Ile Arg Leu Asp Leu Glu Ala Leu Phe Arg Phe Ser His 
        115                 120                 125             


Leu Ile Leu Thr Phe Lys Thr Phe Arg Pro Ala Ala Met Leu Val Glu 
    130                 135                 140                 


Arg Ser Thr Asp Tyr Gly His Asn Trp Lys Val Phe Lys Tyr Phe Ala 
145                 150                 155                 160 


Lys Asp Cys Ala Thr Ser Phe Pro Asn Ile Thr Ser Gly Gln Ala Gln 
                165                 170                 175     


Gly Val Gly Asp Ile Val Cys Asp Ser Lys Tyr Ser Asp Ile Glu Pro 
            180                 185                 190         


Ser Thr Gly Gly Glu Val Val Leu Lys Val Leu Asp Pro Ser Phe Glu 
        195                 200                 205             


Ile Glu Asn Pro Tyr Ser Pro Tyr Ile Gln Asp Leu Val Thr Leu Thr 
    210                 215                 220                 


Asn Leu Arg Ile Asn Phe Thr Lys Leu His Thr Leu Gly Asp Ala Leu 
225                 230                 235                 240 


Leu Gly Arg Arg Gln Asn Asp Ser Leu Asp Lys Tyr Tyr Tyr Ala Leu 
                245                 250                 255     


Tyr Glu Met Ile Val Arg Gly Ser Cys Phe Cys Asn Gly His Ala Ser 
            260                 265                 270         


Glu Cys Arg Pro Met Gln Lys Met Arg Gly Asp Val Phe Ser Pro Pro 
        275                 280                 285             


Gly Met Val His Gly Gln Cys Val Cys Gln His Asn Thr Asp Gly Pro 
    290                 295                 300                 


Asn Cys Glu Arg Cys Lys Asp Phe Phe Gln Asp Ala Pro Trp Arg Pro 
305                 310                 315                 320 


Ala Ala Asp Leu Gln Asp Asn Ala Cys Arg Ser Cys Ser Cys Asn Ser 
                325                 330                 335     


His Ser Ser Arg Cys His Phe Asp Met Thr Thr Tyr Leu Ala Ser Gly 
            340                 345                 350         


Gly Leu Ser Gly Gly Val Cys Glu Asp Cys Gln His Asn Thr Glu Gly 
        355                 360                 365             


Gln His Cys Asp Arg Cys Arg Pro Leu Phe Tyr Arg Asp Pro Leu Lys 
    370                 375                 380                 


Thr Ile Ser Asp Pro Tyr Ala Cys Ile Pro Cys Glu Cys Asp Pro Asp 
385                 390                 395                 400 


Gly Thr Ile Ser Gly Gly Ile Cys Val Ser His Ser Asp Pro Ala Leu 
                405                 410                 415     


Gly Ser Val Ala Gly Gln Cys Leu Cys Lys Glu Asn Val Glu Gly Ala 
            420                 425                 430         


Lys Cys Asp Gln Cys Lys Pro Asn His Tyr Gly Leu Ser Ala Thr Asp 
        435                 440                 445             


Pro Leu Gly Cys Gln Pro Cys Asp Cys Asn Pro Leu Gly Ser Leu Pro 
    450                 455                 460                 


Phe Leu Thr Cys Asp Val Asp Thr Gly Gln Cys Leu Cys Leu Ser Tyr 
465                 470                 475                 480 


Val Thr Gly Ala His Cys Glu Glu Cys Thr Val Gly Tyr Trp Gly Leu 
                485                 490                 495     


Gly Asn His Leu His Gly Cys Ser Pro Cys Asp Cys Asp Ile Gly Gly 
            500                 505                 510         


Ala Tyr Ser Asn Val Cys Ser Pro Lys Asn Gly Gln Cys Glu Cys Arg 
        515                 520                 525             


Pro His Val Thr Gly Arg Ser Cys Ser Glu Pro Ala Pro Gly Tyr Phe 
    530                 535                 540                 


Phe Ala Pro Leu Asn Phe Tyr Leu Tyr Glu Ala Glu Glu Ala Thr Thr 
545                 550                 555                 560 


Leu Gln Gly Leu Ala Pro Leu Gly Ser Glu Thr Phe Gly Gln Ser Pro 
                565                 570                 575     


Ala Val His Val Val Leu Gly Glu Pro Val Pro Gly Asn Pro Val Thr 
            580                 585                 590         


Trp Thr Gly Pro Gly Phe Ala Arg Val Leu Pro Gly Ala Gly Leu Arg 
        595                 600                 605             


Phe Ala Val Asn Asn Ile Pro Phe Pro Val Asp Phe Thr Ile Ala Ile 
    610                 615                 620                 


His Tyr Glu Thr Gln Ser Ala Ala Asp Trp Thr Val Gln Ile Val Val 
625                 630                 635                 640 


Asn Pro Pro Gly Gly Ser Glu His Cys Ile Pro Lys Thr Leu Gln Ser 
                645                 650                 655     


Lys Pro Gln Ser Phe Ala Leu Pro Ala Ala Thr Arg Ile Met Leu Leu 
            660                 665                 670         


Pro Thr Pro Ile Cys Leu Glu Pro Asp Val Gln Tyr Ser Ile Asp Val 
        675                 680                 685             


Tyr Phe Ser Gln Pro Leu Gln Gly Glu Ser His Ala His Ser His Val 
    690                 695                 700                 


Leu Val Asp Ser Leu Gly Leu Ile Pro Gln Ile Asn Ser Leu Glu Asn 
705                 710                 715                 720 


Phe Cys Ser Lys Gln Asp Leu Asp Glu Tyr Gln Leu His Asn Cys Val 
                725                 730                 735     


Glu Ile Ala Ser Ala Met Gly Pro Gln Val Leu Pro Gly Ala Cys Glu 
            740                 745                 750         


Arg Leu Ile Ile Ser Met Ser Ala Lys Leu His Asp Gly Ala Val Ala 
        755                 760                 765             


Cys Lys Cys His Pro Gln Gly Ser Val Gly Ser Ser Cys Ser Arg Leu 
    770                 775                 780                 


Gly Gly Gln Cys Gln Cys Lys Pro Leu Val Val Gly Arg Cys Cys Asp 
785                 790                 795                 800 


Arg Cys Ser Thr Gly Ser Tyr Asp Leu Gly His His Gly Cys His Pro 
                805                 810                 815     


Cys His Cys His Pro Gln Gly Ser Lys Asp Thr Val Cys Asp Gln Val 
            820                 825                 830         


Thr Gly Gln Cys Pro Cys His Gly Glu Val Ser Gly Arg Arg Cys Asp 
        835                 840                 845             


Arg Cys Leu Ala Gly Tyr Phe Gly Phe Pro Ser Cys His Pro Cys Pro 
    850                 855                 860                 


Cys Asn Arg Phe Ala Glu Leu Cys Asp Pro Glu Thr Gly Ser Cys Phe 
865                 870                 875                 880 


Asn Cys Gly Gly Phe Thr Thr Gly Arg Asn Cys Glu Arg Cys Ile Asp 
                885                 890                 895     


Gly Tyr Tyr Gly Asn Pro Ser Ser Gly Gln Pro Cys Arg Pro Cys Leu 
            900                 905                 910         


Cys Pro Asp Asp Pro Ser Ser Asn Gln Tyr Phe Ala His Ser Cys Tyr 
        915                 920                 925             


Gln Asn Leu Trp Ser Ser Asp Val Ile Cys Asn Cys Leu Gln Gly Tyr 
    930                 935                 940                 


Thr Gly Thr Gln Cys Gly Glu Cys Ser Thr Gly Phe Tyr Gly Asn Pro 
945                 950                 955                 960 


Arg Ile Ser Gly Ala Pro Cys Gln Pro Cys Ala Cys Asn Asn Asn Ile 
                965                 970                 975     


Asp Val Thr Asp Pro Glu Ser Cys Ser Arg Val Thr Gly Glu Cys Leu 
            980                 985                 990         


Arg Cys Leu His Asn Thr Gln Gly  Ala Asn Cys Gln Leu  Cys Lys Pro 
        995                 1000                 1005             


Gly His  Tyr Gly Ser Ala Leu  Asn Gln Thr Cys Arg  Arg Cys Ser 
    1010                 1015                 1020             


Cys His  Ala Ser Gly Val Ser  Pro Met Glu Cys Pro  Pro Gly Gly 
    1025                 1030                 1035             


Gly Ala  Cys Leu Cys Asp Pro  Val Thr Gly Ala Cys  Pro Cys Leu 
    1040                 1045                 1050             


Pro Asn  Val Thr Gly Leu Ala  Cys Asp Arg Cys Ala  Asp Gly Tyr 
    1055                 1060                 1065             


Trp Asn  Leu Val Pro Gly Arg  Gly Cys Gln Ser Cys  Asp Cys Asp 
    1070                 1075                 1080             


Pro Arg  Thr Ser Gln Ser Ser  His Cys Asp Gln Leu  Thr Gly Gln 
    1085                 1090                 1095             


Cys Pro  Cys Lys Leu Gly Tyr  Gly Gly Lys Arg Cys  Ser Glu Cys 
    1100                 1105                 1110             


Gln Glu  Asn Tyr Tyr Gly Asp  Pro Pro Gly Arg Cys  Ile Pro Cys 
    1115                 1120                 1125             


Asp Cys  Asn Arg Ala Gly Thr  Gln Lys Pro Ile Cys  Asp Pro Asp 
    1130                 1135                 1140             


Thr Gly  Met Cys Arg Cys Arg  Glu Gly Val Ser Gly  Gln Arg Cys 
    1145                 1150                 1155             


Asp Arg  Cys Ala Arg Gly His  Ser Gln Glu Phe Pro  Thr Cys Leu 
    1160                 1165                 1170             


Gln Cys  His Leu Cys Phe Asp  Gln Trp Asp His Thr  Ile Ser Ser 
    1175                 1180                 1185             


Leu Ser  Lys Ala Val Gln Gly  Leu Met Arg Leu Ala  Ala Asn Met 
    1190                 1195                 1200             


Glu Asp  Lys Arg Glu Thr Leu  Pro Val Cys Glu Ala  Asp Phe Lys 
    1205                 1210                 1215             


Asp Leu  Arg Gly Asn Val Ser  Glu Ile Glu Arg Ile  Leu Lys His 
    1220                 1225                 1230             


Pro Val  Phe Pro Ser Gly Lys  Phe Leu Lys Val Lys  Asp Tyr His 
    1235                 1240                 1245             


Asp Ser  Val Arg Arg Gln Ile  Met Gln Leu Asn Glu  Gln Leu Lys 
    1250                 1255                 1260             


Ala Val  Tyr Glu Phe Gln Asp  Leu Lys Asp Thr Ile  Glu Arg Ala 
    1265                 1270                 1275             


Lys Asn  Glu Ala Asp Leu Leu  Leu Glu Asp Leu Gln  Glu Glu Ile 
    1280                 1285                 1290             


Asp Leu  Gln Ser Ser Val Leu  Asn Ala Ser Ile Ala  Asp Ser Ser 
    1295                 1300                 1305             


Glu Asn  Ile Lys Lys Tyr Tyr  His Ile Ser Ser Ser  Ala Glu Lys 
    1310                 1315                 1320             


Lys Ile  Asn Glu Thr Ser Ser  Thr Ile Asn Thr Ser  Ala Asn Thr 
    1325                 1330                 1335             


Arg Asn  Asp Leu Leu Thr Ile  Leu Asp Thr Leu Thr  Ser Lys Gly 
    1340                 1345                 1350             


Asn Leu  Ser Leu Glu Arg Leu  Lys Gln Ile Lys Ile  Pro Asp Ile 
    1355                 1360                 1365             


Gln Ile  Leu Asn Glu Lys Val  Cys Gly Asp Pro Gly  Asn Val Pro 
    1370                 1375                 1380             


Cys Val  Pro Leu Pro Cys Gly  Gly Ala Leu Cys Thr  Gly Arg Lys 
    1385                 1390                 1395             


Gly His  Arg Lys Cys Arg Gly  Pro Gly Cys His Gly  Ser Leu Thr 
    1400                 1405                 1410             


Leu Ser  Thr Asn Ala Leu Gln  Lys Ala Gln Glu Ala  Lys Ser Ile 
    1415                 1420                 1425             


Ile Arg  Asn Leu Asp Lys Gln  Val Arg Gly Leu Lys  Asn Gln Ile 
    1430                 1435                 1440             


Glu Ser  Ile Ser Glu Gln Ala  Glu Val Ser Lys Asn  Asn Ala Leu 
    1445                 1450                 1455             


Gln Leu  Arg Glu Lys Leu Gly  Asn Ile Arg Asn Gln  Ser Asp Ser 
    1460                 1465                 1470             


Glu Glu  Glu Asn Ile Asn Leu  Phe Ile Lys Lys Val  Lys Asn Phe 
    1475                 1480                 1485             


Leu Leu  Glu Glu Asn Val Pro  Pro Glu Asp Ile Glu  Lys Val Ala 
    1490                 1495                 1500             


Asn Gly  Val Leu Asp Ile His  Leu Pro Ile Pro Ser  Gln Asn Leu 
    1505                 1510                 1515             


Thr Asp  Glu Leu Val Lys Ile  Gln Lys His Met Gln  Leu Cys Glu 
    1520                 1525                 1530             


Asp Tyr  Arg Thr Asp Glu Asn  Arg Leu Asn Glu Glu  Ala Asp Gly 
    1535                 1540                 1545             


Ala Gln  Lys Leu Leu Val Lys  Ala Lys Ala Ala Glu  Lys Ala Ala 
    1550                 1555                 1560             


Asn Ile  Leu Leu Asn Leu Asp  Lys Thr Leu Asn Gln  Leu Gln Gln 
    1565                 1570                 1575             


Ala Gln  Ile Thr Gln Gly Arg  Ala Asn Ser Thr Ile  Thr Gln Leu 
    1580                 1585                 1590             


Thr Ala  Asn Ile Thr Lys Ile  Lys Lys Asn Val Leu  Gln Ala Glu 
    1595                 1600                 1605             


Asn Gln  Thr Arg Glu Met Lys  Ser Glu Leu Glu Leu  Ala Lys Gln 
    1610                 1615                 1620             


Arg Ser  Gly Leu Glu Asp Gly  Leu Ser Leu Leu Gln  Thr Lys Leu 
    1625                 1630                 1635             


Gln Arg  His Gln Asp His Ala  Val Asn Ala Lys Val  Gln Ala Glu 
    1640                 1645                 1650             


Ser Ala  Gln His Gln Ala Gly  Ser Leu Glu Lys Glu  Phe Val Glu 
    1655                 1660                 1665             


Leu Lys  Lys Gln Tyr Ala Ile  Leu Gln Arg Lys Thr  Ser Thr Thr 
    1670                 1675                 1680             


Gly Leu  Thr Lys Glu Thr Leu  Gly Lys Val Lys Gln  Leu Lys Asp 
    1685                 1690                 1695             


Ala Ala  Glu Lys Leu Ala Gly  Asp Thr Glu Ala Lys  Ile Arg Arg 
    1700                 1705                 1710             


Ile Thr  Asp Leu Glu Arg Lys  Ile Gln Asp Leu Asn  Leu Ser Arg 
    1715                 1720                 1725             


Gln Ala  Lys Ala Asp Gln Leu  Arg Ile Leu Glu Asp  Gln Val Val 
    1730                 1735                 1740             


Ala Ile  Lys Asn Glu Ile Val  Glu Gln Glu Lys Lys  Tyr Ala Arg 
    1745                 1750                 1755             


Cys Tyr  Ser 
    1760     


<210>  7689
<211>  1761
<212>  PRT
<213>  Homo Sapiens

<400>  7689

Met Gln Phe Gln Leu Thr Leu Phe Leu His Leu Gly Trp Leu Ser Tyr 
1               5                   10                  15      


Ser Lys Ala Gln Asp Asp Cys Asn Arg Gly Ala Cys His Pro Thr Thr 
            20                  25                  30          


Gly Asp Leu Leu Val Gly Arg Asn Thr Gln Leu Met Ala Ser Ser Thr 
        35                  40                  45              


Cys Gly Leu Ser Arg Ala Gln Lys Tyr Cys Ile Leu Ser Tyr Leu Glu 
    50                  55                  60                  


Gly Glu Gln Lys Cys Phe Ile Cys Asp Ser Arg Phe Pro Tyr Asp Pro 
65                  70                  75                  80  


Tyr Asp Gln Pro Asn Ser His Thr Ile Glu Asn Val Ile Val Ser Phe 
                85                  90                  95      


Glu Pro Asp Arg Glu Lys Lys Trp Trp Gln Ser Glu Asn Gly Leu Asp 
            100                 105                 110         


His Val Ser Ile Arg Leu Asp Leu Glu Ala Leu Phe Arg Phe Ser His 
        115                 120                 125             


Leu Ile Leu Thr Phe Lys Thr Phe Arg Pro Ala Ala Met Leu Val Glu 
    130                 135                 140                 


Arg Ser Thr Asp Tyr Gly His Asn Trp Lys Val Phe Lys Tyr Phe Ala 
145                 150                 155                 160 


Lys Asp Cys Ala Thr Ser Phe Pro Asn Ile Thr Ser Gly Gln Ala Gln 
                165                 170                 175     


Gly Val Gly Asp Ile Val Cys Asp Ser Lys Tyr Ser Asp Ile Glu Pro 
            180                 185                 190         


Ser Thr Gly Gly Glu Val Val Leu Lys Val Leu Asp Pro Ser Phe Glu 
        195                 200                 205             


Ile Glu Asn Pro Tyr Ser Pro Tyr Ile Gln Asp Leu Val Thr Leu Thr 
    210                 215                 220                 


Asn Leu Arg Ile Asn Phe Thr Lys Leu His Thr Leu Gly Asp Ala Leu 
225                 230                 235                 240 


Leu Gly Arg Arg Gln Asn Asp Ser Leu Asp Lys Tyr Tyr Tyr Ala Leu 
                245                 250                 255     


Tyr Glu Met Ile Val Arg Gly Ser Cys Phe Cys Asn Gly His Ala Ser 
            260                 265                 270         


Glu Cys Arg Pro Met Gln Lys Met Arg Gly Asp Val Phe Ser Pro Pro 
        275                 280                 285             


Gly Met Val His Gly Gln Cys Val Cys Gln His Asn Thr Asp Gly Pro 
    290                 295                 300                 


Asn Cys Glu Arg Cys Lys Asp Phe Phe Gln Asp Ala Pro Trp Arg Pro 
305                 310                 315                 320 


Ala Ala Asp Leu Gln Asp Asn Ala Cys Arg Ser Cys Ser Cys Asn Ser 
                325                 330                 335     


His Ser Ser Arg Cys His Phe Asp Met Thr Thr Tyr Leu Ala Ser Gly 
            340                 345                 350         


Gly Leu Ser Gly Gly Val Cys Glu Asp Cys Gln His Asn Thr Glu Gly 
        355                 360                 365             


Gln His Cys Asp Arg Cys Arg Pro Leu Phe Tyr Arg Asp Pro Leu Lys 
    370                 375                 380                 


Thr Ile Ser Asp Pro Tyr Ala Cys Ile Pro Cys Glu Cys Asp Pro Asp 
385                 390                 395                 400 


Gly Thr Ile Ser Gly Gly Ile Cys Val Ser His Ser Asp Pro Ala Leu 
                405                 410                 415     


Gly Ser Val Ala Gly Gln Cys Leu Cys Lys Glu Asn Val Glu Gly Ala 
            420                 425                 430         


Lys Cys Asp Gln Cys Lys Pro Asn His Tyr Gly Leu Ser Ala Thr Asp 
        435                 440                 445             


Pro Leu Gly Cys Gln Pro Cys Asp Cys Asn Pro Leu Gly Ser Leu Pro 
    450                 455                 460                 


Phe Leu Thr Cys Asp Val Asp Thr Gly Gln Cys Leu Cys Leu Ser Tyr 
465                 470                 475                 480 


Val Thr Gly Ala His Cys Glu Glu Cys Thr Val Gly Tyr Trp Gly Leu 
                485                 490                 495     


Gly Asn His Leu His Gly Cys Ser Pro Cys Asp Cys Asp Ile Gly Gly 
            500                 505                 510         


Ala Tyr Ser Asn Val Cys Ser Pro Lys Asn Gly Gln Cys Glu Cys Arg 
        515                 520                 525             


Pro His Val Thr Gly Arg Ser Cys Ser Glu Pro Ala Pro Gly Tyr Phe 
    530                 535                 540                 


Phe Ala Pro Leu Asn Phe Tyr Leu Tyr Glu Ala Glu Glu Ala Thr Thr 
545                 550                 555                 560 


Leu Gln Gly Leu Ala Pro Leu Gly Ser Glu Thr Phe Gly Gln Ser Pro 
                565                 570                 575     


Ala Val His Val Val Leu Gly Glu Pro Val Pro Gly Asn Pro Val Thr 
            580                 585                 590         


Trp Thr Gly Pro Gly Phe Ala Arg Val Leu Pro Gly Ala Gly Leu Arg 
        595                 600                 605             


Phe Ala Val Asn Asn Ile Pro Phe Pro Val Asp Phe Thr Ile Ala Ile 
    610                 615                 620                 


His Tyr Glu Thr Gln Ser Ala Ala Asp Trp Thr Val Gln Ile Val Val 
625                 630                 635                 640 


Asn Pro Pro Gly Gly Ser Glu His Cys Ile Pro Lys Thr Leu Gln Ser 
                645                 650                 655     


Lys Pro Gln Ser Phe Ala Leu Pro Ala Ala Thr Arg Ile Met Leu Leu 
            660                 665                 670         


Pro Thr Pro Ile Cys Leu Glu Pro Asp Val Gln Tyr Ser Ile Asp Val 
        675                 680                 685             


Tyr Phe Ser Gln Pro Leu Gln Gly Glu Ser His Ala His Ser His Val 
    690                 695                 700                 


Leu Val Asp Ser Leu Gly Leu Ile Pro Gln Ile Asn Ser Leu Glu Asn 
705                 710                 715                 720 


Phe Cys Ser Lys Gln Asp Leu Asp Glu Tyr Gln Leu His Asn Cys Val 
                725                 730                 735     


Glu Ile Ala Ser Ala Met Gly Pro Gln Val Leu Pro Gly Ala Cys Glu 
            740                 745                 750         


Arg Leu Ile Ile Ser Met Ser Ala Lys Leu His Asp Gly Ala Val Ala 
        755                 760                 765             


Cys Lys Cys His Pro Gln Gly Ser Val Gly Ser Ser Cys Ser Arg Leu 
    770                 775                 780                 


Gly Gly Gln Cys Gln Cys Lys Pro Leu Val Val Gly Arg Cys Cys Asp 
785                 790                 795                 800 


Arg Cys Ser Thr Gly Ser Tyr Asp Leu Gly His His Gly Cys His Pro 
                805                 810                 815     


Cys His Cys His Pro Gln Gly Ser Lys Asp Thr Val Cys Asp Gln Val 
            820                 825                 830         


Thr Gly Gln Cys Pro Cys His Gly Glu Val Ser Gly Arg Arg Cys Asp 
        835                 840                 845             


Arg Cys Leu Ala Gly Tyr Phe Gly Phe Pro Ser Cys His Pro Cys Pro 
    850                 855                 860                 


Cys Asn Arg Phe Ala Glu Leu Cys Asp Pro Glu Thr Gly Ser Cys Phe 
865                 870                 875                 880 


Asn Cys Gly Gly Phe Thr Thr Gly Arg Asn Cys Glu Arg Cys Ile Asp 
                885                 890                 895     


Gly Tyr Tyr Gly Asn Pro Ser Ser Gly Gln Pro Cys Arg Pro Cys Leu 
            900                 905                 910         


Cys Pro Asp Asp Pro Ser Ser Asn Gln Tyr Phe Ala His Ser Cys Tyr 
        915                 920                 925             


Gln Asn Leu Trp Ser Ser Asp Val Ile Cys Asn Cys Leu Gln Gly Tyr 
    930                 935                 940                 


Thr Gly Thr Gln Cys Gly Glu Cys Ser Thr Gly Phe Tyr Gly Asn Pro 
945                 950                 955                 960 


Arg Ile Ser Gly Ala Pro Cys Gln Pro Cys Ala Cys Asn Asn Asn Ile 
                965                 970                 975     


Asp Val Thr Asp Pro Glu Ser Cys Ser Arg Val Thr Gly Glu Cys Leu 
            980                 985                 990         


Arg Cys Leu His Asn Thr Gln Gly  Ala Asn Cys Gln Leu  Cys Lys Pro 
        995                 1000                 1005             


Gly His  Tyr Gly Ser Ala Leu  Asn Gln Thr Cys Arg  Arg Cys Ser 
    1010                 1015                 1020             


Cys His  Ala Ser Gly Val Ser  Pro Met Glu Cys Pro  Pro Gly Gly 
    1025                 1030                 1035             


Gly Ala  Cys Leu Cys Asp Pro  Val Thr Gly Ala Cys  Pro Cys Leu 
    1040                 1045                 1050             


Pro Asn  Val Thr Gly Leu Ala  Cys Asp Arg Cys Ala  Asp Gly Tyr 
    1055                 1060                 1065             


Trp Asn  Leu Val Pro Gly Arg  Gly Cys Gln Ser Cys  Asp Cys Asp 
    1070                 1075                 1080             


Pro Arg  Thr Ser Gln Ser Ser  His Cys Asp Gln Leu  Thr Gly Gln 
    1085                 1090                 1095             


Cys Pro  Cys Lys Leu Gly Tyr  Gly Gly Lys Arg Cys  Ser Glu Cys 
    1100                 1105                 1110             


Gln Glu  Asn Tyr Tyr Gly Asp  Pro Pro Gly Arg Cys  Ile Pro Cys 
    1115                 1120                 1125             


Asp Cys  Asn Arg Ala Gly Thr  Gln Lys Pro Ile Cys  Asp Pro Asp 
    1130                 1135                 1140             


Thr Gly  Met Cys Arg Cys Arg  Glu Gly Val Ser Gly  Gln Arg Cys 
    1145                 1150                 1155             


Asp Arg  Cys Ala Arg Gly His  Ser Gln Glu Phe Pro  Thr Cys Leu 
    1160                 1165                 1170             


Gln Cys  His Leu Cys Phe Asp  Gln Trp Asp His Thr  Ile Ser Ser 
    1175                 1180                 1185             


Leu Ser  Lys Ala Val Gln Gly  Leu Met Arg Leu Ala  Ala Asn Met 
    1190                 1195                 1200             


Glu Asp  Lys Arg Glu Thr Leu  Pro Val Cys Glu Ala  Asp Phe Lys 
    1205                 1210                 1215             


Asp Leu  Arg Gly Asn Val Ser  Glu Ile Glu Arg Ile  Leu Lys His 
    1220                 1225                 1230             


Pro Val  Phe Pro Ser Gly Lys  Phe Leu Lys Val Lys  Asp Tyr His 
    1235                 1240                 1245             


Asp Ser  Val Arg Arg Gln Ile  Met Gln Leu Asn Glu  Gln Leu Lys 
    1250                 1255                 1260             


Ala Val  Tyr Glu Phe Gln Asp  Leu Lys Asp Thr Ile  Glu Arg Ala 
    1265                 1270                 1275             


Lys Asn  Glu Ala Asp Leu Leu  Leu Glu Asp Leu Gln  Glu Glu Ile 
    1280                 1285                 1290             


Asp Leu  Gln Ser Ser Val Leu  Asn Ala Ser Ile Ala  Asp Ser Ser 
    1295                 1300                 1305             


Glu Asn  Ile Lys Lys Tyr Tyr  His Ile Ser Ser Ser  Ala Glu Lys 
    1310                 1315                 1320             


Lys Ile  Asn Glu Thr Ser Ser  Thr Ile Asn Thr Ser  Ala Asn Thr 
    1325                 1330                 1335             


Arg Asn  Asp Leu Leu Thr Ile  Leu Asp Thr Leu Thr  Ser Lys Gly 
    1340                 1345                 1350             


Asn Leu  Ser Leu Glu Arg Leu  Lys Gln Ile Lys Ile  Pro Asp Ile 
    1355                 1360                 1365             


Gln Ile  Leu Asn Glu Lys Val  Cys Gly Asp Pro Gly  Asn Val Pro 
    1370                 1375                 1380             


Cys Val  Pro Leu Pro Cys Gly  Gly Ala Leu Cys Thr  Gly Arg Lys 
    1385                 1390                 1395             


Gly His  Arg Lys Cys Arg Gly  Pro Gly Cys His Gly  Ser Leu Thr 
    1400                 1405                 1410             


Leu Ser  Thr Asn Ala Leu Gln  Lys Ala Gln Glu Ala  Lys Ser Ile 
    1415                 1420                 1425             


Ile Arg  Asn Leu Asp Lys Gln  Val Arg Gly Leu Lys  Asn Gln Ile 
    1430                 1435                 1440             


Glu Ser  Ile Ser Glu Gln Ala  Glu Val Ser Lys Asn  Asn Ala Leu 
    1445                 1450                 1455             


Gln Leu  Arg Glu Lys Leu Gly  Asn Ile Arg Asn Gln  Ser Asp Ser 
    1460                 1465                 1470             


Glu Glu  Glu Asn Ile Asn Leu  Phe Ile Lys Lys Val  Lys Asn Phe 
    1475                 1480                 1485             


Leu Leu  Glu Glu Asn Val Pro  Pro Glu Asp Ile Glu  Lys Val Ala 
    1490                 1495                 1500             


Asn Gly  Val Leu Asp Ile His  Leu Pro Ile Pro Ser  Gln Asn Leu 
    1505                 1510                 1515             


Thr Asp  Glu Leu Val Lys Ile  Gln Lys His Met Gln  Leu Cys Glu 
    1520                 1525                 1530             


Asp Tyr  Arg Thr Asp Glu Asn  Arg Leu Asn Glu Glu  Ala Asp Gly 
    1535                 1540                 1545             


Ala Gln  Lys Leu Leu Val Lys  Ala Lys Ala Ala Glu  Lys Ala Ala 
    1550                 1555                 1560             


Asn Ile  Leu Leu Asn Leu Asp  Lys Thr Leu Asn Gln  Leu Gln Gln 
    1565                 1570                 1575             


Ala Gln  Ile Thr Gln Gly Arg  Ala Asn Ser Thr Ile  Thr Gln Leu 
    1580                 1585                 1590             


Thr Ala  Asn Ile Thr Lys Ile  Lys Lys Asn Val Leu  Gln Ala Glu 
    1595                 1600                 1605             


Asn Gln  Thr Arg Glu Met Lys  Ser Glu Leu Glu Leu  Ala Lys Gln 
    1610                 1615                 1620             


Arg Ser  Gly Leu Glu Asp Gly  Leu Ser Leu Leu Gln  Thr Lys Leu 
    1625                 1630                 1635             


Gln Arg  His Gln Asp His Ala  Val Asn Ala Lys Val  Gln Ala Glu 
    1640                 1645                 1650             


Ser Ala  Gln His Gln Ala Gly  Ser Leu Glu Lys Glu  Phe Val Glu 
    1655                 1660                 1665             


Leu Lys  Lys Gln Tyr Ala Ile  Leu Gln Arg Lys Thr  Ser Thr Thr 
    1670                 1675                 1680             


Gly Leu  Thr Lys Glu Thr Leu  Gly Lys Val Lys Gln  Leu Lys Asp 
    1685                 1690                 1695             


Ala Ala  Glu Lys Leu Ala Gly  Asp Thr Glu Ala Lys  Ile Arg Arg 
    1700                 1705                 1710             


Ile Thr  Asp Leu Glu Arg Lys  Ile Gln Asp Leu Asn  Leu Ser Arg 
    1715                 1720                 1725             


Gln Ala  Lys Ala Asp Gln Leu  Arg Ile Leu Glu Asp  Gln Val Val 
    1730                 1735                 1740             


Ala Ile  Lys Asn Glu Ile Val  Glu Gln Glu Lys Lys  Tyr Ala Arg 
    1745                 1750                 1755             


Cys Tyr  Ser 
    1760     


<210>  7690
<211>  772
<212>  PRT
<213>  Homo Sapiens

<400>  7690

Met Gln Phe Gln Leu Thr Leu Phe Leu His Leu Gly Trp Leu Ser Tyr 
1               5                   10                  15      


Ser Lys Ala Gln Asp Asp Cys Asn Arg Gly Ala Cys His Pro Thr Thr 
            20                  25                  30          


Gly Asp Leu Leu Val Gly Arg Asn Thr Gln Leu Met Ala Ser Ser Thr 
        35                  40                  45              


Cys Gly Leu Ser Arg Ala Gln Lys Tyr Cys Ile Leu Ser Tyr Leu Glu 
    50                  55                  60                  


Gly Glu Gln Lys Cys Phe Ile Cys Asp Ser Arg Phe Pro Tyr Asp Pro 
65                  70                  75                  80  


Tyr Asp Gln Pro Asn Ser His Thr Ile Glu Asn Val Ile Val Ser Phe 
                85                  90                  95      


Glu Pro Asp Arg Glu Lys Lys Trp Trp Gln Ser Glu Asn Gly Leu Asp 
            100                 105                 110         


His Val Ser Ile Arg Leu Asp Leu Glu Ala Leu Phe Arg Phe Ser His 
        115                 120                 125             


Leu Ile Leu Thr Phe Lys Thr Phe Arg Pro Ala Ala Met Leu Val Glu 
    130                 135                 140                 


Arg Ser Thr Asp Tyr Gly His Asn Trp Lys Val Phe Lys Tyr Phe Ala 
145                 150                 155                 160 


Lys Asp Cys Ala Thr Ser Phe Pro Asn Ile Thr Ser Gly Gln Ala Gln 
                165                 170                 175     


Gly Val Gly Asp Ile Val Cys Asp Ser Lys Tyr Ser Asp Ile Glu Pro 
            180                 185                 190         


Ser Thr Gly Gly Glu Val Val Leu Lys Val Leu Asp Pro Ser Phe Glu 
        195                 200                 205             


Ile Glu Asn Pro Tyr Ser Pro Tyr Ile Gln Asp Leu Val Thr Leu Thr 
    210                 215                 220                 


Asn Leu Arg Ile Asn Phe Thr Lys Leu His Thr Leu Gly Asp Ala Leu 
225                 230                 235                 240 


Leu Gly Arg Arg Gln Asn Asp Ser Leu Asp Lys Tyr Tyr Tyr Ala Leu 
                245                 250                 255     


Tyr Glu Met Ile Val Arg Gly Ser Cys Phe Cys Asn Gly His Ala Ser 
            260                 265                 270         


Glu Cys Arg Pro Met Gln Lys Met Arg Gly Asp Val Phe Ser Pro Pro 
        275                 280                 285             


Gly Met Val His Gly Gln Cys Val Cys Gln His Asn Thr Asp Gly Pro 
    290                 295                 300                 


Asn Cys Glu Arg Cys Lys Asp Phe Phe Gln Asp Ala Pro Trp Arg Pro 
305                 310                 315                 320 


Ala Ala Asp Leu Gln Asp Asn Ala Cys Arg Ser Cys Ser Cys Asn Ser 
                325                 330                 335     


His Ser Ser Arg Cys His Phe Asp Met Thr Thr Tyr Leu Ala Ser Gly 
            340                 345                 350         


Gly Leu Ser Gly Gly Val Cys Glu Asp Cys Gln His Asn Thr Glu Gly 
        355                 360                 365             


Gln His Cys Asp Arg Cys Arg Pro Leu Phe Tyr Arg Asp Pro Leu Lys 
    370                 375                 380                 


Thr Ile Ser Asp Pro Tyr Ala Cys Ile Pro Cys Glu Cys Asp Pro Asp 
385                 390                 395                 400 


Gly Thr Ile Ser Gly Gly Ile Cys Val Ser His Ser Asp Pro Ala Leu 
                405                 410                 415     


Gly Ser Val Ala Gly Gln Cys Leu Cys Lys Glu Asn Val Glu Gly Ala 
            420                 425                 430         


Lys Cys Asp Gln Cys Lys Pro Asn His Tyr Gly Leu Ser Ala Thr Asp 
        435                 440                 445             


Pro Leu Gly Cys Gln Pro Cys Asp Cys Asn Pro Leu Gly Ser Leu Pro 
    450                 455                 460                 


Phe Leu Thr Cys Asp Val Asp Thr Gly Gln Cys Leu Cys Leu Ser Tyr 
465                 470                 475                 480 


Val Thr Gly Ala His Cys Glu Glu Cys Thr Val Gly Tyr Trp Gly Leu 
                485                 490                 495     


Gly Asn His Leu His Gly Cys Ser Pro Cys Asp Cys Asp Ile Gly Gly 
            500                 505                 510         


Ala Tyr Ser Asn Val Cys Ser Pro Lys Asn Gly Gln Cys Glu Cys Arg 
        515                 520                 525             


Pro His Val Thr Gly Arg Ser Cys Ser Glu Pro Ala Pro Gly Tyr Phe 
    530                 535                 540                 


Phe Ala Pro Leu Asn Phe Tyr Leu Tyr Glu Ala Glu Glu Ala Thr Thr 
545                 550                 555                 560 


Leu Gln Gly Leu Ala Pro Leu Gly Ser Glu Thr Phe Gly Gln Ser Pro 
                565                 570                 575     


Ala Val His Val Val Leu Gly Glu Pro Val Pro Gly Asn Pro Val Thr 
            580                 585                 590         


Trp Thr Gly Pro Gly Phe Ala Arg Val Leu Pro Gly Ala Gly Leu Arg 
        595                 600                 605             


Phe Ala Val Asn Asn Ile Pro Phe Pro Val Asp Phe Thr Ile Ala Ile 
    610                 615                 620                 


His Tyr Glu Thr Gln Ser Ala Ala Asp Trp Thr Val Gln Ile Val Val 
625                 630                 635                 640 


Asn Pro Pro Gly Gly Ser Glu His Cys Ile Pro Lys Thr Leu Gln Ser 
                645                 650                 655     


Lys Pro Gln Ser Phe Ala Leu Pro Ala Ala Thr Arg Ile Met Leu Leu 
            660                 665                 670         


Pro Thr Pro Ile Cys Leu Glu Pro Asp Val Gln Tyr Ser Ile Asp Val 
        675                 680                 685             


Tyr Phe Ser Gln Pro Leu Gln Gly Glu Ser His Ala His Ser His Val 
    690                 695                 700                 


Leu Val Asp Ser Ala Ala Val Gln Trp His Asn Leu Gly Ser Leu Gln 
705                 710                 715                 720 


Pro Pro Pro Pro Glu Cys Lys Gln Phe Ser Cys Phe Ser Phe Pro Ser 
                725                 730                 735     


Ser Trp Asp Tyr Arg His Pro Pro Pro His Leu Ala Asn Phe Cys Ile 
            740                 745                 750         


Phe Ser Arg Asp Gly Val Ser Pro His Trp Pro Gly Trp Ser Gln Thr 
        755                 760                 765             


Pro Asp Leu Arg 
    770         


<210>  7691
<211>  749
<212>  PRT
<213>  Homo Sapiens

<400>  7691

Asn Ile Asp Val Thr Asp Pro Glu Ser Cys Ser Arg Val Thr Gly Glu 
1               5                   10                  15      


Cys Leu Arg Cys Leu His Asn Thr Gln Gly Ala Asn Cys Gln Leu Cys 
            20                  25                  30          


Lys Pro Gly His Tyr Gly Ser Ala Leu Asn Gln Thr Cys Arg Arg Cys 
        35                  40                  45              


Ser Cys His Ala Ser Gly Val Ser Pro Met Glu Cys Pro Pro Gly Gly 
    50                  55                  60                  


Gly Ala Cys Leu Cys Asp Pro Val Thr Gly Ala Cys Pro Cys Leu Pro 
65                  70                  75                  80  


Asn Val Thr Gly Leu Ala Cys Asp Arg Cys Ala Asp Gly Tyr Trp Asn 
                85                  90                  95      


Leu Val Pro Gly Arg Gly Cys Gln Ser Cys Asp Cys Asp Pro Arg Thr 
            100                 105                 110         


Ser Gln Ser Ser His Cys Asp Gln Leu Thr Gly Gln Cys Pro Cys Lys 
        115                 120                 125             


Leu Gly Tyr Gly Gly Lys Arg Cys Ser Glu Cys Gln Glu Asn Tyr Tyr 
    130                 135                 140                 


Gly Asp Pro Pro Gly Arg Cys Ile Pro Cys Asp Cys Asn Arg Ala Gly 
145                 150                 155                 160 


Thr Gln Lys Pro Ile Cys Asp Pro Asp Thr Gly Met Cys Arg Cys Arg 
                165                 170                 175     


Glu Gly Val Ser Gly Gln Arg Cys Asp Arg Cys Ala Arg Gly His Ser 
            180                 185                 190         


Gln Glu Phe Pro Thr Cys Leu Gln Cys His Leu Cys Phe Asp Gln Trp 
        195                 200                 205             


Asp His Thr Ile Ser Ser Leu Ser Lys Ala Val Gln Gly Leu Met Arg 
    210                 215                 220                 


Leu Ala Ala Asn Met Glu Asp Lys Arg Glu Thr Leu Pro Val Cys Glu 
225                 230                 235                 240 


Ala Asp Phe Lys Asp Leu Arg Gly Asn Val Ser Glu Ile Glu Arg Ile 
                245                 250                 255     


Leu Lys His Pro Val Phe Pro Ser Gly Lys Phe Leu Lys Val Lys Asp 
            260                 265                 270         


Tyr His Asp Ser Val Arg Arg Gln Ile Met Gln Leu Asn Glu Gln Leu 
        275                 280                 285             


Lys Ala Val Tyr Glu Phe Gln Asp Leu Lys Asp Thr Ile Glu Arg Ala 
    290                 295                 300                 


Lys Asn Glu Ala Asp Leu Leu Leu Glu Asp Leu Gln Glu Glu Ile Asp 
305                 310                 315                 320 


Leu Gln Ser Ser Val Leu Asn Ala Ser Ile Ala Asp Ser Ser Glu Asn 
                325                 330                 335     


Ile Lys Lys Tyr Tyr His Ile Ser Ser Ser Ala Glu Lys Lys Ile Asn 
            340                 345                 350         


Glu Thr Ser Ser Thr Ile Asn Thr Ser Ala Asn Thr Arg Asn Asp Leu 
        355                 360                 365             


Leu Thr Ile Leu Asp Thr Leu Thr Ser Lys Gly Asn Leu Ser Leu Glu 
    370                 375                 380                 


Arg Leu Lys Gln Ile Lys Ile Pro Asp Ile Gln Ile Leu Asn Glu Lys 
385                 390                 395                 400 


Val Cys Gly Asp Pro Gly Asn Val Pro Cys Val Pro Leu Pro Cys Gly 
                405                 410                 415     


Gly Ala Leu Cys Thr Gly Arg Lys Gly His Arg Lys Cys Arg Gly Pro 
            420                 425                 430         


Gly Cys His Gly Ser Leu Thr Leu Ser Thr Asn Ala Leu Gln Lys Ala 
        435                 440                 445             


Gln Glu Ala Lys Ser Ile Ile Arg Asn Leu Asp Lys Gln Val Arg Gly 
    450                 455                 460                 


Leu Lys Asn Gln Ile Glu Ser Ile Ser Glu Gln Ala Glu Val Ser Lys 
465                 470                 475                 480 


Asn Asn Ala Leu Gln Leu Arg Glu Lys Leu Gly Asn Ile Arg Asn Gln 
                485                 490                 495     


Ser Asp Ser Glu Glu Glu Asn Ile Asn Leu Phe Ile Lys Lys Val Lys 
            500                 505                 510         


Asn Phe Leu Leu Glu Glu Asn Val Pro Pro Glu Asp Ile Glu Lys Val 
        515                 520                 525             


Ala Asn Gly Val Leu Asp Ile His Leu Pro Ile Pro Ser Gln Asn Leu 
    530                 535                 540                 


Thr Asp Glu Leu Val Lys Ile Gln Lys His Met Gln Leu Cys Glu Asp 
545                 550                 555                 560 


Tyr Arg Thr Asp Glu Asn Arg Leu Asn Glu Glu Ala Asp Gly Ala Gln 
                565                 570                 575     


Lys Leu Leu Val Lys Ala Lys Ala Ala Glu Lys Ala Ala Asn Ile Leu 
            580                 585                 590         


Leu Asn Leu Asp Lys Thr Leu Asn Gln Leu Gln Gln Ala Gln Ile Thr 
        595                 600                 605             


Gln Gly Arg Ala Asn Ser Thr Ile Thr Gln Leu Thr Ala Asn Ile Thr 
    610                 615                 620                 


Lys Ile Lys Lys Asn Val Leu Gln Ala Glu Asn Gln Thr Arg Glu Met 
625                 630                 635                 640 


Lys Ser Glu Leu Glu Leu Ala Lys Gln Arg Ser Gly Leu Glu Asp Gly 
                645                 650                 655     


Leu Ser Leu Leu Gln Thr Lys Leu Gln Arg His Gln Asp His Ala Val 
            660                 665                 670         


Asn Ala Lys Val Gln Ala Glu Ser Ala Gln His Gln Ala Gly Ser Leu 
        675                 680                 685             


Glu Lys Glu Phe Val Glu Leu Lys Lys Gln Tyr Ala Ile Leu Gln Arg 
    690                 695                 700                 


Lys Thr Ser Thr Thr Gly Leu Thr Lys Glu Thr Leu Gly Lys Val Lys 
705                 710                 715                 720 


Gln Leu Lys Asp Ala Ala Glu Lys Leu Ala Gly Asp Thr Glu Ala Lys 
                725                 730                 735     


Ile Arg Arg Ile Thr Gly Cys Phe Gln Asn Ser Ala Arg 
            740                 745                 


<210>  7692
<211>  38
<212>  PRT
<213>  Homo Sapiens

<400>  7692

Met Lys Asn Glu Phe Asp Lys Leu Val Cys Asn Cys Lys His Asn Thr 
1               5                   10                  15      


Tyr Gly Val Asp Cys Glu Lys Cys Leu Pro Phe Phe Asn Asp Arg Pro 
            20                  25                  30          


Trp Arg Arg Ala Thr Ala 
        35              


<210>  7693
<211>  1609
<212>  PRT
<213>  Homo Sapiens

<400>  7693

Met Arg Gly Ser His Arg Ala Ala Pro Ala Leu Arg Pro Arg Gly Arg 
1               5                   10                  15      


Leu Trp Pro Val Leu Ala Val Leu Ala Ala Ala Ala Ala Ala Gly Cys 
            20                  25                  30          


Ala Gln Ala Ala Met Asp Glu Cys Thr Asp Glu Gly Gly Arg Pro Gln 
        35                  40                  45              


Arg Cys Met Pro Glu Phe Val Asn Ala Ala Phe Asn Val Thr Val Val 
    50                  55                  60                  


Ala Thr Asn Thr Cys Gly Thr Pro Pro Glu Glu Tyr Cys Val Gln Thr 
65                  70                  75                  80  


Gly Val Thr Gly Val Thr Lys Ser Cys His Leu Cys Asp Ala Gly Gln 
                85                  90                  95      


Pro His Leu Gln His Gly Ala Ala Phe Leu Thr Asp Tyr Asn Asn Gln 
            100                 105                 110         


Ala Asp Thr Thr Trp Trp Gln Ser Gln Thr Met Leu Ala Gly Val Gln 
        115                 120                 125             


Tyr Pro Ser Ser Ile Asn Leu Thr Leu His Leu Gly Lys Ala Phe Asp 
    130                 135                 140                 


Ile Thr Tyr Val Arg Leu Lys Phe His Thr Ser Arg Pro Glu Ser Phe 
145                 150                 155                 160 


Ala Ile Tyr Lys Arg Thr Arg Glu Asp Gly Pro Trp Ile Pro Tyr Gln 
                165                 170                 175     


Tyr Tyr Ser Gly Ser Cys Glu Asn Thr Tyr Ser Lys Ala Asn Arg Gly 
            180                 185                 190         


Phe Ile Arg Thr Gly Gly Asp Glu Gln Gln Ala Leu Cys Thr Asp Glu 
        195                 200                 205             


Phe Ser Asp Ile Ser Pro Leu Thr Gly Gly Asn Val Ala Phe Ser Thr 
    210                 215                 220                 


Leu Glu Gly Arg Pro Ser Ala Tyr Asn Phe Asp Asn Ser Pro Val Leu 
225                 230                 235                 240 


Gln Glu Trp Val Thr Ala Thr Asp Ile Arg Val Thr Leu Asn Arg Leu 
                245                 250                 255     


Asn Thr Phe Gly Asp Glu Val Phe Asn Asp Pro Lys Val Leu Lys Ser 
            260                 265                 270         


Tyr Tyr Tyr Ala Ile Ser Asp Phe Ala Val Gly Gly Arg Cys Lys Cys 
        275                 280                 285             


Asn Gly His Ala Ser Glu Cys Met Lys Asn Glu Phe Asp Lys Leu Val 
    290                 295                 300                 


Cys Asn Cys Lys His Asn Thr Tyr Gly Val Asp Cys Glu Lys Cys Leu 
305                 310                 315                 320 


Pro Phe Phe Asn Asp Arg Pro Trp Arg Arg Ala Thr Ala Glu Ser Ala 
                325                 330                 335     


Ser Glu Cys Leu Pro Cys Asp Cys Asn Gly Arg Ser Gln Glu Cys Tyr 
            340                 345                 350         


Phe Asp Pro Glu Leu Tyr Arg Ser Thr Gly His Gly Gly His Cys Thr 
        355                 360                 365             


Asn Cys Gln Asp Asn Thr Asp Gly Ala His Cys Glu Arg Cys Arg Glu 
    370                 375                 380                 


Asn Phe Phe Arg Leu Gly Asn Asn Glu Ala Cys Ser Ser Cys His Cys 
385                 390                 395                 400 


Ser Pro Val Gly Ser Leu Ser Thr Gln Cys Asp Ser Tyr Gly Arg Cys 
                405                 410                 415     


Ser Cys Lys Pro Gly Val Met Gly Asp Lys Cys Asp Arg Cys Gln Pro 
            420                 425                 430         


Gly Phe His Ser Leu Thr Glu Ala Gly Cys Arg Pro Cys Ser Cys Asp 
        435                 440                 445             


Pro Ser Gly Ser Ile Asp Glu Cys Asn Ile Glu Thr Gly Arg Cys Val 
    450                 455                 460                 


Cys Lys Asp Asn Val Glu Gly Phe Asn Cys Glu Arg Cys Lys Pro Gly 
465                 470                 475                 480 


Phe Phe Asn Leu Glu Ser Ser Asn Pro Arg Gly Cys Thr Pro Cys Phe 
                485                 490                 495     


Cys Phe Gly His Ser Ser Val Cys Thr Asn Ala Val Gly Tyr Ser Val 
            500                 505                 510         


Tyr Ser Ile Ser Ser Thr Phe Gln Ile Asp Glu Asp Gly Trp Arg Ala 
        515                 520                 525             


Glu Gln Arg Asp Gly Ser Glu Ala Ser Leu Glu Trp Ser Ser Glu Arg 
    530                 535                 540                 


Gln Asp Ile Ala Val Ile Ser Asp Ser Tyr Phe Pro Arg Tyr Phe Ile 
545                 550                 555                 560 


Ala Pro Ala Lys Phe Leu Gly Lys Gln Val Leu Ser Tyr Gly Gln Asn 
                565                 570                 575     


Leu Ser Phe Ser Phe Arg Val Asp Arg Arg Asp Thr Arg Leu Ser Ala 
            580                 585                 590         


Glu Asp Leu Val Leu Glu Gly Ala Gly Leu Arg Val Ser Val Pro Leu 
        595                 600                 605             


Ile Ala Gln Gly Asn Ser Tyr Pro Ser Glu Thr Thr Val Lys Tyr Val 
    610                 615                 620                 


Phe Arg Leu His Glu Ala Thr Asp Tyr Pro Trp Arg Pro Ala Leu Thr 
625                 630                 635                 640 


Pro Phe Glu Phe Gln Lys Leu Leu Asn Asn Leu Thr Ser Ile Lys Ile 
                645                 650                 655     


Arg Gly Thr Tyr Ser Glu Arg Ser Ala Gly Tyr Leu Asp Asp Val Thr 
            660                 665                 670         


Leu Ala Ser Ala Arg Pro Gly Pro Gly Val Pro Ala Thr Trp Val Glu 
        675                 680                 685             


Ser Cys Thr Cys Pro Val Gly Tyr Gly Gly Gln Phe Cys Glu Met Cys 
    690                 695                 700                 


Leu Ser Gly Tyr Arg Arg Glu Thr Pro Asn Leu Gly Pro Tyr Ser Pro 
705                 710                 715                 720 


Cys Val Leu Cys Ala Cys Asn Gly His Ser Glu Thr Cys Asp Pro Glu 
                725                 730                 735     


Thr Gly Val Cys Asn Cys Arg Asp Asn Thr Ala Gly Pro His Cys Glu 
            740                 745                 750         


Lys Cys Ser Asp Gly Tyr Tyr Gly Asp Ser Thr Ala Gly Thr Ser Ser 
        755                 760                 765             


Asp Cys Gln Pro Cys Pro Cys Pro Gly Gly Ser Ser Cys Ala Val Val 
    770                 775                 780                 


Pro Lys Thr Lys Glu Val Val Cys Thr Asn Cys Pro Thr Gly Thr Thr 
785                 790                 795                 800 


Gly Lys Arg Cys Glu Leu Cys Asp Asp Gly Tyr Phe Gly Asp Pro Leu 
                805                 810                 815     


Gly Arg Asn Gly Pro Val Arg Leu Cys Arg Leu Cys Gln Cys Ser Asp 
            820                 825                 830         


Asn Ile Asp Pro Asn Ala Val Gly Asn Cys Asn Arg Leu Thr Gly Glu 
        835                 840                 845             


Cys Leu Lys Cys Ile Tyr Asn Thr Ala Gly Phe Tyr Cys Asp Arg Cys 
    850                 855                 860                 


Lys Asp Gly Phe Phe Gly Asn Pro Leu Ala Pro Asn Pro Ala Asp Lys 
865                 870                 875                 880 


Cys Lys Ala Cys Asn Cys Asn Leu Tyr Gly Thr Met Lys Gln Gln Ser 
                885                 890                 895     


Ser Cys Asn Pro Val Thr Gly Gln Cys Glu Cys Leu Pro His Val Thr 
            900                 905                 910         


Gly Gln Asp Cys Gly Ala Cys Asp Pro Gly Phe Tyr Asn Leu Gln Ser 
        915                 920                 925             


Gly Gln Gly Cys Glu Arg Cys Asp Cys His Ala Leu Gly Ser Thr Asn 
    930                 935                 940                 


Gly Gln Cys Asp Ile Arg Thr Gly Gln Cys Glu Cys Gln Pro Gly Ile 
945                 950                 955                 960 


Thr Gly Gln His Cys Glu Arg Cys Glu Val Asn His Phe Gly Phe Gly 
                965                 970                 975     


Pro Glu Gly Cys Lys Pro Cys Asp Cys His Pro Glu Gly Ser Leu Ser 
            980                 985                 990         


Leu Gln Cys Lys Asp Asp Gly Arg  Cys Glu Cys Arg Glu  Gly Phe Val 
        995                 1000                 1005             


Gly Asn  Arg Cys Asp Gln Cys  Glu Glu Asn Tyr Phe  Tyr Asn Arg 
    1010                 1015                 1020             


Ser Trp  Pro Gly Cys Gln Glu  Cys Pro Ala Cys Tyr  Arg Leu Val 
    1025                 1030                 1035             


Lys Asp  Lys Val Ala Asp His  Arg Val Lys Leu Gln  Glu Leu Glu 
    1040                 1045                 1050             


Ser Leu  Ile Ala Asn Leu Gly  Thr Gly Asp Glu Met  Val Thr Asp 
    1055                 1060                 1065             


Gln Ala  Phe Glu Asp Arg Leu  Lys Glu Ala Glu Arg  Glu Val Met 
    1070                 1075                 1080             


Asp Leu  Leu Arg Glu Ala Gln  Asp Val Lys Asp Val  Asp Gln Asn 
    1085                 1090                 1095             


Leu Met  Asp Arg Leu Gln Arg  Val Asn Asn Thr Leu  Ser Ser Gln 
    1100                 1105                 1110             


Ile Ser  Arg Leu Gln Asn Ile  Arg Asn Thr Ile Glu  Glu Thr Gly 
    1115                 1120                 1125             


Asn Leu  Ala Glu Gln Ala Arg  Ala His Val Glu Asn  Thr Glu Arg 
    1130                 1135                 1140             


Leu Ile  Glu Ile Ala Ser Arg  Glu Leu Glu Lys Ala  Lys Val Ala 
    1145                 1150                 1155             


Ala Ala  Asn Val Ser Val Thr  Gln Pro Glu Ser Thr  Gly Asp Pro 
    1160                 1165                 1170             


Asn Asn  Met Thr Leu Leu Ala  Glu Glu Ala Arg Lys  Leu Ala Glu 
    1175                 1180                 1185             


Arg His  Lys Gln Glu Ala Asp  Asp Ile Val Arg Val  Ala Lys Thr 
    1190                 1195                 1200             


Ala Asn  Asp Thr Ser Thr Glu  Ala Tyr Asn Leu Leu  Leu Arg Thr 
    1205                 1210                 1215             


Leu Ala  Gly Glu Asn Gln Thr  Ala Phe Glu Ile Glu  Glu Leu Asn 
    1220                 1225                 1230             


Arg Lys  Tyr Glu Gln Ala Lys  Asn Ile Ser Gln Asp  Leu Glu Lys 
    1235                 1240                 1245             


Gln Ala  Ala Arg Val His Glu  Glu Ala Lys Arg Ala  Gly Asp Lys 
    1250                 1255                 1260             


Ala Val  Glu Ile Tyr Ala Ser  Val Ala Gln Leu Ser  Pro Leu Asp 
    1265                 1270                 1275             


Ser Glu  Thr Leu Glu Asn Glu  Ala Asn Asn Ile Lys  Met Glu Ala 
    1280                 1285                 1290             


Glu Asn  Leu Glu Gln Leu Ile  Asp Gln Lys Leu Lys  Asp Tyr Glu 
    1295                 1300                 1305             


Asp Leu  Arg Glu Asp Met Arg  Gly Lys Glu Leu Glu  Val Lys Asn 
    1310                 1315                 1320             


Leu Leu  Glu Lys Gly Lys Thr  Glu Gln Gln Thr Ala  Asp Gln Leu 
    1325                 1330                 1335             


Leu Ala  Arg Ala Asp Ala Ala  Lys Ala Leu Ala Glu  Glu Ala Ala 
    1340                 1345                 1350             


Lys Lys  Gly Arg Asp Thr Leu  Gln Glu Ala Asn Asp  Ile Leu Asn 
    1355                 1360                 1365             


Asn Leu  Lys Asp Phe Asp Arg  Arg Val Asn Asp Asn  Lys Thr Ala 
    1370                 1375                 1380             


Ala Glu  Glu Ala Leu Arg Lys  Ile Pro Ala Ile Asn  Gln Thr Ile 
    1385                 1390                 1395             


Thr Glu  Ala Asn Glu Lys Thr  Arg Glu Ala Gln Gln  Ala Leu Gly 
    1400                 1405                 1410             


Ser Ala  Ala Ala Asp Ala Thr  Glu Ala Lys Asn Lys  Ala His Glu 
    1415                 1420                 1425             


Ala Glu  Arg Ile Ala Ser Ala  Val Gln Lys Asn Ala  Thr Ser Thr 
    1430                 1435                 1440             


Lys Ala  Glu Ala Glu Arg Thr  Phe Ala Glu Val Thr  Asp Leu Asp 
    1445                 1450                 1455             


Asn Glu  Val Asn Asn Met Leu  Lys Gln Leu Gln Glu  Ala Glu Lys 
    1460                 1465                 1470             


Glu Leu  Lys Arg Lys Gln Asp  Asp Ala Asp Gln Asp  Met Met Met 
    1475                 1480                 1485             


Ala Gly  Met Ala Ser Gln Ala  Ala Gln Glu Ala Glu  Ile Asn Ala 
    1490                 1495                 1500             


Arg Lys  Ala Lys Asn Ser Val  Thr Ser Leu Leu Ser  Ile Ile Asn 
    1505                 1510                 1515             


Asp Leu  Leu Glu Gln Leu Gly  Gln Leu Asp Thr Val  Asp Leu Asn 
    1520                 1525                 1530             


Lys Leu  Asn Glu Ile Glu Gly  Thr Leu Asn Lys Ala  Lys Asp Glu 
    1535                 1540                 1545             


Met Lys  Val Ser Asp Leu Asp  Arg Lys Val Ser Asp  Leu Glu Asn 
    1550                 1555                 1560             


Glu Ala  Lys Lys Gln Glu Ala  Ala Ile Met Asp Tyr  Asn Arg Asp 
    1565                 1570                 1575             


Ile Glu  Glu Ile Met Lys Asp  Ile Arg Asn Leu Glu  Asp Ile Arg 
    1580                 1585                 1590             


Lys Thr  Leu Pro Ser Gly Cys  Phe Asn Thr Pro Ser  Ile Glu Lys 
    1595                 1600                 1605             


Pro 
    


<210>  7694
<211>  1193
<212>  PRT
<213>  Homo Sapiens

<400>  7694

Met Pro Ala Leu Trp Leu Gly Cys Cys Leu Cys Phe Ser Leu Leu Leu 
1               5                   10                  15      


Pro Ala Ala Arg Ala Thr Ser Arg Arg Glu Val Cys Asp Cys Asn Gly 
            20                  25                  30          


Lys Ser Arg Gln Cys Ile Phe Asp Arg Glu Leu His Arg Gln Thr Gly 
        35                  40                  45              


Asn Gly Phe Arg Cys Leu Asn Cys Asn Asp Asn Thr Asp Gly Ile His 
    50                  55                  60                  


Cys Glu Lys Cys Lys Asn Gly Phe Tyr Arg His Arg Glu Arg Asp Arg 
65                  70                  75                  80  


Cys Leu Pro Cys Asn Cys Asn Ser Lys Gly Ser Leu Ser Ala Arg Cys 
                85                  90                  95      


Asp Asn Ser Gly Arg Cys Ser Cys Lys Pro Gly Val Thr Gly Ala Arg 
            100                 105                 110         


Cys Asp Arg Cys Leu Pro Gly Phe His Met Leu Thr Asp Ala Gly Cys 
        115                 120                 125             


Thr Gln Asp Gln Arg Leu Leu Asp Ser Lys Cys Asp Cys Asp Pro Ala 
    130                 135                 140                 


Gly Ile Ala Gly Pro Cys Asp Ala Gly Arg Cys Val Cys Lys Pro Ala 
145                 150                 155                 160 


Val Thr Gly Glu Arg Cys Asp Arg Cys Arg Ser Gly Tyr Tyr Asn Leu 
                165                 170                 175     


Asp Gly Gly Asn Pro Glu Gly Cys Thr Gln Cys Phe Cys Tyr Gly His 
            180                 185                 190         


Ser Ala Ser Cys Arg Ser Ser Ala Glu Tyr Ser Val His Lys Ile Thr 
        195                 200                 205             


Ser Thr Phe His Gln Asp Val Asp Gly Trp Lys Ala Val Gln Arg Asn 
    210                 215                 220                 


Gly Ser Pro Ala Lys Leu Gln Trp Ser Gln Arg His Gln Asp Val Phe 
225                 230                 235                 240 


Ser Ser Ala Gln Arg Leu Asp Pro Val Tyr Phe Val Ala Pro Ala Lys 
                245                 250                 255     


Phe Leu Gly Asn Gln Gln Val Ser Tyr Gly Gln Ser Leu Ser Phe Asp 
            260                 265                 270         


Tyr Arg Val Asp Arg Gly Gly Arg His Pro Ser Ala His Asp Val Ile 
        275                 280                 285             


Leu Glu Gly Ala Gly Leu Arg Ile Thr Ala Pro Leu Met Pro Leu Gly 
    290                 295                 300                 


Lys Thr Leu Pro Cys Gly Leu Thr Lys Thr Tyr Thr Phe Arg Leu Asn 
305                 310                 315                 320 


Glu His Pro Ser Asn Asn Trp Ser Pro Gln Leu Ser Tyr Phe Glu Tyr 
                325                 330                 335     


Arg Arg Leu Leu Arg Asn Leu Thr Ala Leu Arg Ile Arg Ala Thr Tyr 
            340                 345                 350         


Gly Glu Tyr Ser Thr Gly Tyr Ile Asp Asn Val Thr Leu Ile Ser Ala 
        355                 360                 365             


Arg Pro Val Ser Gly Ala Pro Ala Pro Trp Val Glu Gln Cys Ile Cys 
    370                 375                 380                 


Pro Val Gly Tyr Lys Gly Gln Phe Cys Gln Asp Cys Ala Ser Gly Tyr 
385                 390                 395                 400 


Lys Arg Asp Ser Ala Arg Leu Gly Pro Phe Gly Thr Cys Ile Pro Cys 
                405                 410                 415     


Asn Cys Gln Gly Gly Gly Ala Cys Asp Pro Asp Thr Gly Asp Cys Tyr 
            420                 425                 430         


Ser Gly Asp Glu Asn Pro Asp Ile Glu Cys Ala Asp Cys Pro Ile Gly 
        435                 440                 445             


Phe Tyr Asn Asp Pro His Asp Pro Arg Ser Cys Lys Pro Cys Pro Cys 
    450                 455                 460                 


His Asn Gly Phe Ser Cys Ser Val Met Pro Glu Thr Glu Glu Val Val 
465                 470                 475                 480 


Cys Asn Asn Cys Pro Pro Gly Val Thr Gly Ala Arg Cys Glu Leu Cys 
                485                 490                 495     


Ala Asp Gly Tyr Phe Gly Asp Pro Phe Gly Glu His Gly Pro Val Arg 
            500                 505                 510         


Pro Cys Gln Pro Cys Gln Cys Asn Asn Asn Val Asp Pro Ser Ala Ser 
        515                 520                 525             


Gly Asn Cys Asp Arg Leu Thr Gly Arg Cys Leu Lys Cys Ile His Asn 
    530                 535                 540                 


Thr Ala Gly Ile Tyr Cys Asp Gln Cys Lys Ala Gly Tyr Phe Gly Asp 
545                 550                 555                 560 


Pro Leu Ala Pro Asn Pro Ala Asp Lys Cys Arg Ala Cys Asn Cys Asn 
                565                 570                 575     


Pro Met Gly Ser Glu Pro Val Gly Cys Arg Ser Asp Gly Thr Cys Val 
            580                 585                 590         


Cys Lys Pro Gly Phe Gly Gly Pro Asn Cys Glu His Gly Ala Phe Ser 
        595                 600                 605             


Cys Pro Ala Cys Tyr Asn Gln Val Lys Ile Gln Met Asp Gln Phe Met 
    610                 615                 620                 


Gln Gln Leu Gln Arg Met Glu Ala Leu Ile Ser Lys Ala Gln Gly Gly 
625                 630                 635                 640 


Asp Gly Val Val Pro Asp Thr Glu Leu Glu Gly Arg Met Gln Gln Ala 
                645                 650                 655     


Glu Gln Ala Leu Gln Asp Ile Leu Arg Asp Ala Gln Ile Ser Glu Gly 
            660                 665                 670         


Ala Ser Arg Ser Leu Gly Leu Gln Leu Ala Lys Val Arg Ser Gln Glu 
        675                 680                 685             


Asn Ser Tyr Gln Ser Arg Leu Asp Asp Leu Lys Met Thr Val Glu Arg 
    690                 695                 700                 


Val Arg Ala Leu Gly Ser Gln Tyr Gln Asn Arg Val Arg Asp Thr His 
705                 710                 715                 720 


Arg Leu Ile Thr Gln Met Gln Leu Ser Leu Ala Glu Ser Glu Ala Ser 
                725                 730                 735     


Leu Gly Asn Thr Asn Ile Pro Ala Ser Asp His Tyr Val Gly Pro Asn 
            740                 745                 750         


Gly Phe Lys Ser Leu Ala Gln Glu Ala Thr Arg Leu Ala Glu Ser His 
        755                 760                 765             


Val Glu Ser Ala Ser Asn Met Glu Gln Leu Thr Arg Glu Thr Glu Asp 
    770                 775                 780                 


Tyr Ser Lys Gln Ala Leu Ser Leu Val Arg Lys Ala Leu His Glu Gly 
785                 790                 795                 800 


Val Gly Ser Gly Ser Gly Ser Pro Asp Gly Ala Val Val Gln Gly Leu 
                805                 810                 815     


Val Glu Lys Leu Glu Lys Thr Lys Ser Leu Ala Gln Gln Leu Thr Arg 
            820                 825                 830         


Glu Ala Thr Gln Ala Glu Ile Glu Ala Asp Arg Ser Tyr Gln His Ser 
        835                 840                 845             


Leu Arg Leu Leu Asp Ser Val Ser Arg Leu Gln Gly Val Ser Asp Gln 
    850                 855                 860                 


Ser Phe Gln Val Glu Glu Ala Lys Arg Ile Lys Gln Lys Ala Asp Ser 
865                 870                 875                 880 


Leu Ser Ser Leu Val Thr Arg His Met Asp Glu Phe Lys Arg Thr Gln 
                885                 890                 895     


Lys Asn Leu Gly Asn Trp Lys Glu Glu Ala Gln Gln Leu Leu Gln Asn 
            900                 905                 910         


Gly Lys Ser Gly Arg Glu Lys Ser Asp Gln Leu Leu Ser Arg Ala Asn 
        915                 920                 925             


Leu Ala Lys Ser Arg Ala Gln Glu Ala Leu Ser Met Gly Asn Ala Thr 
    930                 935                 940                 


Phe Tyr Glu Val Glu Ser Ile Leu Lys Asn Leu Arg Glu Phe Asp Leu 
945                 950                 955                 960 


Gln Val Asp Asn Arg Lys Ala Glu Ala Glu Glu Ala Met Lys Arg Leu 
                965                 970                 975     


Ser Tyr Ile Ser Gln Lys Val Ser Asp Ala Ser Asp Lys Thr Gln Gln 
            980                 985                 990         


Ala Glu Arg Ala Leu Gly Ser Ala  Ala Ala Asp Ala Gln  Arg Ala Lys 
        995                 1000                 1005             


Asn Gly  Ala Gly Glu Ala Leu  Glu Ile Ser Ser Glu  Ile Glu Gln 
    1010                 1015                 1020             


Glu Ile  Gly Ser Leu Asn Leu  Glu Ala Asn Val Thr  Ala Asp Gly 
    1025                 1030                 1035             


Ala Leu  Ala Met Glu Lys Gly  Leu Ala Ser Leu Lys  Ser Glu Met 
    1040                 1045                 1050             


Arg Glu  Val Glu Gly Glu Leu  Glu Arg Lys Glu Leu  Glu Phe Asp 
    1055                 1060                 1065             


Thr Asn  Met Asp Ala Val Gln  Met Val Ile Thr Glu  Ala Gln Lys 
    1070                 1075                 1080             


Val Asp  Thr Arg Ala Lys Asn  Ala Gly Val Thr Ile  Gln Asp Thr 
    1085                 1090                 1095             


Leu Asn  Thr Leu Asp Gly Leu  Leu His Leu Met Asp  Gln Pro Leu 
    1100                 1105                 1110             


Ser Val  Asp Glu Glu Gly Leu  Val Leu Leu Glu Gln  Lys Leu Ser 
    1115                 1120                 1125             


Arg Ala  Lys Thr Gln Ile Asn  Ser Gln Leu Arg Pro  Met Met Ser 
    1130                 1135                 1140             


Glu Leu  Glu Glu Arg Ala Arg  Gln Gln Arg Gly His  Leu His Leu 
    1145                 1150                 1155             


Leu Glu  Thr Ser Ile Asp Gly  Ile Leu Ala Asp Val  Lys Asn Leu 
    1160                 1165                 1170             


Glu Asn  Ile Arg Asp Asn Leu  Pro Pro Gly Cys Tyr  Asn Thr Gln 
    1175                 1180                 1185             


Ala Leu  Glu Gln Gln 
    1190             


<210>  7695
<211>  1111
<212>  PRT
<213>  Homo Sapiens

<400>  7695

Met Pro Ala Leu Trp Leu Gly Cys Cys Leu Cys Phe Ser Leu Leu Leu 
1               5                   10                  15      


Pro Ala Ala Arg Ala Thr Ser Arg Arg Glu Val Cys Asp Cys Asn Gly 
            20                  25                  30          


Lys Ser Arg Gln Cys Ile Phe Asp Arg Glu Leu His Arg Gln Thr Gly 
        35                  40                  45              


Asn Gly Phe Arg Cys Leu Asn Cys Asn Asp Asn Thr Asp Gly Ile His 
    50                  55                  60                  


Cys Glu Lys Cys Lys Asn Gly Phe Tyr Arg His Arg Glu Arg Asp Arg 
65                  70                  75                  80  


Cys Leu Pro Cys Asn Cys Asn Ser Lys Gly Ser Leu Ser Ala Arg Cys 
                85                  90                  95      


Asp Asn Ser Gly Arg Cys Ser Cys Lys Pro Gly Val Thr Gly Ala Arg 
            100                 105                 110         


Cys Asp Arg Cys Leu Pro Gly Phe His Met Leu Thr Asp Ala Gly Cys 
        115                 120                 125             


Thr Gln Asp Gln Arg Leu Leu Asp Ser Lys Cys Asp Cys Asp Pro Ala 
    130                 135                 140                 


Gly Ile Ala Gly Pro Cys Asp Ala Gly Arg Cys Val Cys Lys Pro Ala 
145                 150                 155                 160 


Val Thr Gly Glu Arg Cys Asp Arg Cys Arg Ser Gly Tyr Tyr Asn Leu 
                165                 170                 175     


Asp Gly Gly Asn Pro Glu Gly Cys Thr Gln Cys Phe Cys Tyr Gly His 
            180                 185                 190         


Ser Ala Ser Cys Arg Ser Ser Ala Glu Tyr Ser Val His Lys Ile Thr 
        195                 200                 205             


Ser Thr Phe His Gln Asp Val Asp Gly Trp Lys Ala Val Gln Arg Asn 
    210                 215                 220                 


Gly Ser Pro Ala Lys Leu Gln Trp Ser Gln Arg His Gln Asp Val Phe 
225                 230                 235                 240 


Ser Ser Ala Gln Arg Leu Asp Pro Val Tyr Phe Val Ala Pro Ala Lys 
                245                 250                 255     


Phe Leu Gly Asn Gln Gln Val Ser Tyr Gly Gln Ser Leu Ser Phe Asp 
            260                 265                 270         


Tyr Arg Val Asp Arg Gly Gly Arg His Pro Ser Ala His Asp Val Ile 
        275                 280                 285             


Leu Glu Gly Ala Gly Leu Arg Ile Thr Ala Pro Leu Met Pro Leu Gly 
    290                 295                 300                 


Lys Thr Leu Pro Cys Gly Leu Thr Lys Thr Tyr Thr Phe Arg Leu Asn 
305                 310                 315                 320 


Glu His Pro Ser Asn Asn Trp Ser Pro Gln Leu Ser Tyr Phe Glu Tyr 
                325                 330                 335     


Arg Arg Leu Leu Arg Asn Leu Thr Ala Leu Arg Ile Arg Ala Thr Tyr 
            340                 345                 350         


Gly Glu Tyr Ser Thr Gly Tyr Ile Asp Asn Val Thr Leu Ile Ser Ala 
        355                 360                 365             


Arg Pro Val Ser Gly Ala Pro Ala Pro Trp Val Glu Gln Cys Ile Cys 
    370                 375                 380                 


Pro Val Gly Tyr Lys Gly Gln Phe Cys Gln Asp Cys Ala Ser Gly Tyr 
385                 390                 395                 400 


Lys Arg Asp Ser Ala Arg Leu Gly Pro Phe Gly Thr Cys Ile Pro Cys 
                405                 410                 415     


Asn Cys Gln Gly Gly Gly Ala Cys Asp Pro Asp Thr Gly Asp Cys Tyr 
            420                 425                 430         


Ser Gly Asp Glu Asn Pro Asp Ile Glu Cys Ala Asp Cys Pro Ile Gly 
        435                 440                 445             


Phe Tyr Asn Asp Pro His Asp Pro Arg Ser Cys Lys Pro Cys Pro Cys 
    450                 455                 460                 


His Asn Gly Phe Ser Cys Ser Val Met Pro Glu Thr Glu Glu Val Val 
465                 470                 475                 480 


Cys Asn Asn Cys Pro Pro Gly Val Thr Gly Ala Arg Cys Glu Leu Cys 
                485                 490                 495     


Ala Asp Gly Tyr Phe Gly Asp Pro Phe Gly Glu His Gly Pro Val Arg 
            500                 505                 510         


Pro Cys Gln Pro Cys Gln Cys Asn Asn Asn Val Asp Pro Ser Ala Ser 
        515                 520                 525             


Gly Asn Cys Asp Arg Leu Thr Gly Arg Cys Leu Lys Cys Ile His Asn 
    530                 535                 540                 


Thr Ala Gly Ile Tyr Cys Asp Gln Cys Lys Ala Gly Tyr Phe Gly Asp 
545                 550                 555                 560 


Pro Leu Ala Pro Asn Pro Ala Asp Lys Cys Arg Ala Cys Asn Cys Asn 
                565                 570                 575     


Pro Met Gly Ser Glu Pro Val Gly Cys Arg Ser Asp Gly Thr Cys Val 
            580                 585                 590         


Cys Lys Pro Gly Phe Gly Gly Pro Asn Cys Glu His Gly Ala Phe Ser 
        595                 600                 605             


Cys Pro Ala Cys Tyr Asn Gln Val Lys Ile Gln Met Asp Gln Phe Met 
    610                 615                 620                 


Gln Gln Leu Gln Arg Met Glu Ala Leu Ile Ser Lys Ala Gln Gly Gly 
625                 630                 635                 640 


Asp Gly Val Val Pro Asp Thr Glu Leu Glu Gly Arg Met Gln Gln Ala 
                645                 650                 655     


Glu Gln Ala Leu Gln Asp Ile Leu Arg Asp Ala Gln Ile Ser Glu Gly 
            660                 665                 670         


Ala Ser Arg Ser Leu Gly Leu Gln Leu Ala Lys Val Arg Ser Gln Glu 
        675                 680                 685             


Asn Ser Tyr Gln Ser Arg Leu Asp Asp Leu Lys Met Thr Val Glu Arg 
    690                 695                 700                 


Val Arg Ala Leu Gly Ser Gln Tyr Gln Asn Arg Val Arg Asp Thr His 
705                 710                 715                 720 


Arg Leu Ile Thr Gln Met Gln Leu Ser Leu Ala Glu Ser Glu Ala Ser 
                725                 730                 735     


Leu Gly Asn Thr Asn Ile Pro Ala Ser Asp His Tyr Val Gly Pro Asn 
            740                 745                 750         


Gly Phe Lys Ser Leu Ala Gln Glu Ala Thr Arg Leu Ala Glu Ser His 
        755                 760                 765             


Val Glu Ser Ala Ser Asn Met Glu Gln Leu Thr Arg Glu Thr Glu Asp 
    770                 775                 780                 


Tyr Ser Lys Gln Ala Leu Ser Leu Val Arg Lys Ala Leu His Glu Gly 
785                 790                 795                 800 


Val Gly Ser Gly Ser Gly Ser Pro Asp Gly Ala Val Val Gln Gly Leu 
                805                 810                 815     


Val Glu Lys Leu Glu Lys Thr Lys Ser Leu Ala Gln Gln Leu Thr Arg 
            820                 825                 830         


Glu Ala Thr Gln Ala Glu Ile Glu Ala Asp Arg Ser Tyr Gln His Ser 
        835                 840                 845             


Leu Arg Leu Leu Asp Ser Val Ser Arg Leu Gln Gly Val Ser Asp Gln 
    850                 855                 860                 


Ser Phe Gln Val Glu Glu Ala Lys Arg Ile Lys Gln Lys Ala Asp Ser 
865                 870                 875                 880 


Leu Ser Ser Leu Val Thr Arg His Met Asp Glu Phe Lys Arg Thr Gln 
                885                 890                 895     


Lys Asn Leu Gly Asn Trp Lys Glu Glu Ala Gln Gln Leu Leu Gln Asn 
            900                 905                 910         


Gly Lys Ser Gly Arg Glu Lys Ser Asp Gln Leu Leu Ser Arg Ala Asn 
        915                 920                 925             


Leu Ala Lys Ser Arg Ala Gln Glu Ala Leu Ser Met Gly Asn Ala Thr 
    930                 935                 940                 


Phe Tyr Glu Val Glu Ser Ile Leu Lys Asn Leu Arg Glu Phe Asp Leu 
945                 950                 955                 960 


Gln Val Asp Asn Arg Lys Ala Glu Ala Glu Glu Ala Met Lys Arg Leu 
                965                 970                 975     


Ser Tyr Ile Ser Gln Lys Val Ser Asp Ala Ser Asp Lys Thr Gln Gln 
            980                 985                 990         


Ala Glu Arg Ala Leu Gly Ser Ala  Ala Ala Asp Ala Gln  Arg Ala Lys 
        995                 1000                 1005             


Asn Gly  Ala Gly Glu Ala Leu  Glu Ile Ser Ser Glu  Ile Glu Gln 
    1010                 1015                 1020             


Glu Ile  Gly Ser Leu Asn Leu  Glu Ala Asn Val Thr  Ala Asp Gly 
    1025                 1030                 1035             


Ala Leu  Ala Met Glu Lys Gly  Leu Ala Ser Leu Lys  Ser Glu Met 
    1040                 1045                 1050             


Arg Glu  Val Glu Gly Glu Leu  Glu Arg Lys Glu Leu  Glu Phe Asp 
    1055                 1060                 1065             


Thr Asn  Met Asp Ala Val Gln  Met Val Ile Thr Glu  Ala Gln Lys 
    1070                 1075                 1080             


Val Asp  Thr Arg Ala Lys Asn  Ala Gly Val Thr Ile  Gln Asp Thr 
    1085                 1090                 1095             


Leu Asn  Thr Leu Asp Gly Leu  Leu His Leu Met Gly  Met 
    1100                 1105                 1110     


<210>  7696
<211>  1575
<212>  PRT
<213>  Homo Sapiens

<400>  7696

Met Ala Ala Ala Ala Leu Leu Leu Gly Leu Ala Leu Leu Ala Pro Arg 
1               5                   10                  15      


Ala Ala Gly Ala Gly Met Gly Ala Cys Tyr Asp Gly Ala Gly Arg Pro 
            20                  25                  30          


Gln Arg Cys Leu Pro Val Phe Glu Asn Ala Ala Phe Gly Arg Leu Ala 
        35                  40                  45              


Gln Ala Ser His Thr Cys Gly Ser Pro Pro Glu Asp Phe Cys Pro His 
    50                  55                  60                  


Val Gly Ala Ala Gly Ala Gly Ala His Cys Gln Arg Cys Asp Ala Ala 
65                  70                  75                  80  


Asp Pro Gln Arg His His Asn Ala Ser Tyr Leu Thr Asp Phe His Ser 
                85                  90                  95      


Gln Asp Glu Ser Thr Trp Trp Gln Ser Pro Ser Met Ala Phe Gly Val 
            100                 105                 110         


Gln Tyr Pro Thr Ser Val Asn Ile Thr Leu Arg Leu Gly Lys Ala Tyr 
        115                 120                 125             


Glu Ile Thr Tyr Val Arg Leu Lys Phe His Thr Ser Arg Pro Glu Ser 
    130                 135                 140                 


Phe Ala Ile Tyr Lys Arg Ser Arg Ala Asp Gly Pro Trp Glu Pro Tyr 
145                 150                 155                 160 


Gln Phe Tyr Ser Ala Ser Cys Gln Lys Thr Tyr Gly Arg Pro Glu Gly 
                165                 170                 175     


Gln Tyr Leu Arg Pro Gly Glu Asp Glu Arg Val Ala Phe Cys Thr Ser 
            180                 185                 190         


Glu Phe Ser Asp Ile Ser Pro Leu Ser Gly Gly Asn Val Ala Phe Ser 
        195                 200                 205             


Thr Leu Glu Gly Arg Pro Ser Ala Tyr Asn Phe Glu Glu Ser Pro Gly 
    210                 215                 220                 


Leu Gln Glu Trp Val Thr Ser Thr Glu Leu Leu Ile Ser Leu Asp Arg 
225                 230                 235                 240 


Leu Asn Thr Phe Gly Asp Asp Ile Phe Lys Asp Pro Lys Val Leu Gln 
                245                 250                 255     


Ser Tyr Tyr Tyr Ala Val Ser Asp Phe Ser Val Gly Gly Arg Cys Lys 
            260                 265                 270         


Cys Asn Gly His Ala Ser Glu Cys Gly Pro Asp Val Ala Gly Gln Leu 
        275                 280                 285             


Ala Cys Arg Cys Gln His Asn Thr Thr Gly Thr Asp Cys Glu Arg Cys 
    290                 295                 300                 


Leu Pro Phe Phe Gln Asp Arg Pro Trp Ala Arg Gly Thr Ala Glu Ala 
305                 310                 315                 320 


Ala His Glu Cys Leu Pro Cys Asn Cys Ser Gly Arg Ser Glu Glu Cys 
                325                 330                 335     


Thr Phe Asp Arg Glu Leu Phe Arg Ser Thr Gly His Gly Gly Arg Cys 
            340                 345                 350         


His His Cys Arg Asp His Thr Ala Gly Pro His Cys Glu Arg Cys Gln 
        355                 360                 365             


Glu Asn Phe Tyr His Trp Asp Pro Arg Met Pro Cys Gln Pro Cys Asp 
    370                 375                 380                 


Cys Gln Ser Ala Gly Ser Leu His Leu Gln Cys Asp Asp Thr Gly Thr 
385                 390                 395                 400 


Cys Ala Cys Lys Pro Thr Val Thr Gly Trp Lys Cys Asp Arg Cys Leu 
                405                 410                 415     


Pro Gly Phe His Ser Leu Ser Glu Gly Gly Cys Arg Pro Cys Thr Cys 
            420                 425                 430         


Asn Pro Ala Gly Ser Leu Asp Thr Cys Asp Pro Arg Ser Gly Arg Cys 
        435                 440                 445             


Pro Cys Lys Glu Asn Val Glu Gly Asn Leu Cys Asp Arg Cys Arg Pro 
    450                 455                 460                 


Gly Thr Phe Asn Leu Gln Pro His Asn Pro Ala Gly Cys Ser Ser Cys 
465                 470                 475                 480 


Phe Cys Tyr Gly His Ser Lys Val Cys Ala Ser Thr Ala Gln Phe Gln 
                485                 490                 495     


Val His His Ile Leu Ser Asp Phe His Gln Gly Ala Glu Gly Trp Trp 
            500                 505                 510         


Ala Arg Ser Val Gly Gly Ser Glu His Pro Pro Gln Trp Ser Pro Asn 
        515                 520                 525             


Gly Val Leu Leu Ser Pro Glu Asp Glu Glu Glu Leu Thr Ala Pro Glu 
    530                 535                 540                 


Lys Phe Leu Gly Asp Gln Arg Phe Ser Tyr Gly Gln Pro Leu Ile Leu 
545                 550                 555                 560 


Thr Phe Arg Val Pro Pro Gly Asp Ser Pro Leu Pro Val Gln Leu Arg 
                565                 570                 575     


Leu Glu Gly Thr Gly Leu Ala Leu Ser Leu Arg His Ser Ser Leu Ser 
            580                 585                 590         


Gly Pro Gln Asp Ala Gly His Pro Arg Glu Val Glu Leu Arg Phe His 
        595                 600                 605             


Leu Gln Glu Thr Ser Glu Asp Val Ala Pro Pro Leu Pro Pro Phe His 
    610                 615                 620                 


Phe Gln Arg Leu Leu Ala Asn Leu Thr Ser Leu Arg Leu Arg Val Ser 
625                 630                 635                 640 


Pro Gly Pro Ser Pro Ala Gly Pro Val Phe Leu Thr Glu Val Arg Leu 
                645                 650                 655     


Thr Ser Ala Arg Pro Gly Leu Ser Pro Pro Ala Ser Trp Val Glu Ile 
            660                 665                 670         


Cys Ser Cys Pro Thr Gly Tyr Thr Gly Gln Phe Cys Glu Ser Cys Ala 
        675                 680                 685             


Pro Gly Tyr Lys Arg Glu Met Pro Gln Gly Gly Pro Tyr Ala Ser Cys 
    690                 695                 700                 


Val Pro Cys Thr Cys Asn Gln His Gly Thr Cys Asp Pro Asn Thr Gly 
705                 710                 715                 720 


Ile Cys Val Cys Ser His His Thr Glu Gly Pro Ser Cys Glu Arg Cys 
                725                 730                 735     


Leu Pro Gly Phe Tyr Gly Asn Pro Phe Ala Gly Gln Ala Asp Asp Cys 
            740                 745                 750         


Gln Pro Cys Pro Cys Pro Gly Gln Ser Ala Cys Thr Thr Ile Pro Glu 
        755                 760                 765             


Ser Arg Glu Val Val Cys Thr His Cys Pro Pro Gly Gln Arg Gly Arg 
    770                 775                 780                 


Arg Cys Glu Val Cys Asp Asp Gly Phe Phe Gly Asp Pro Leu Gly Leu 
785                 790                 795                 800 


Phe Gly His Pro Gln Pro Cys His Gln Cys Gln Cys Ser Gly Asn Val 
                805                 810                 815     


Asp Pro Asn Ala Val Gly Asn Cys Asp Pro Leu Ser Gly His Cys Leu 
            820                 825                 830         


Arg Cys Leu His Asn Thr Thr Gly Asp His Cys Glu His Cys Gln Glu 
        835                 840                 845             


Gly Phe Tyr Gly Ser Ala Leu Ala Pro Arg Pro Ala Asp Lys Cys Met 
    850                 855                 860                 


Pro Cys Ser Cys His Pro Gln Gly Ser Val Ser Glu Gln Met Pro Cys 
865                 870                 875                 880 


Asp Pro Val Thr Gly Gln Cys Ser Cys Leu Pro His Val Thr Ala Arg 
                885                 890                 895     


Asp Cys Ser Arg Cys Tyr Pro Gly Phe Phe Asp Leu Gln Pro Gly Arg 
            900                 905                 910         


Gly Cys Arg Ser Cys Lys Cys His Pro Leu Gly Ser Gln Glu Asp Gln 
        915                 920                 925             


Cys His Pro Lys Thr Gly Gln Cys Thr Cys Arg Pro Gly Val Thr Gly 
    930                 935                 940                 


Gln Ala Cys Asp Arg Cys Gln Leu Gly Phe Phe Gly Phe Ser Ile Lys 
945                 950                 955                 960 


Gly Cys Arg Ala Cys Arg Cys Ser Pro Leu Gly Ala Ala Ser Ala Gln 
                965                 970                 975     


Cys His Glu Asn Gly Thr Cys Val Cys Arg Pro Gly Phe Glu Gly Tyr 
            980                 985                 990         


Lys Cys Asp Arg Cys His Asp Asn  Phe Phe Leu Thr Ala  Asp Gly Thr 
        995                 1000                 1005             


His Cys  Gln Gln Cys Pro Ser  Cys Tyr Ala Leu Val  Lys Glu Glu 
    1010                 1015                 1020             


Ala Ala  Lys Leu Lys Ala Arg  Leu Thr Leu Thr Glu  Gly Trp Leu 
    1025                 1030                 1035             


Gln Gly  Ser Asp Cys Gly Ser  Pro Trp Gly Pro Leu  Asp Ile Leu 
    1040                 1045                 1050             


Leu Gly  Glu Ala Pro Arg Gly  Asp Val Tyr Gln Gly  His His Leu 
    1055                 1060                 1065             


Leu Pro  Gly Ala Arg Glu Ala  Phe Leu Glu Gln Met  Met Ser Leu 
    1070                 1075                 1080             


Glu Gly  Ala Val Lys Ala Ala  Arg Glu Gln Leu Gln  Arg Leu Asn 
    1085                 1090                 1095             


Lys Gly  Ala Arg Cys Ala Gln  Ala Gly Ser Gln Lys  Thr Cys Thr 
    1100                 1105                 1110             


Gln Leu  Ala Asp Leu Glu Ala  Val Leu Glu Ser Ser  Glu Glu Glu 
    1115                 1120                 1125             


Ile Leu  His Ala Ala Ala Ile  Leu Ala Ser Leu Glu  Ile Pro Gln 
    1130                 1135                 1140             


Glu Gly  Pro Ser Gln Pro Thr  Lys Trp Ser His Leu  Ala Thr Glu 
    1145                 1150                 1155             


Ala Arg  Ala Leu Ala Arg Ser  His Arg Asp Thr Ala  Thr Lys Ile 
    1160                 1165                 1170             


Ala Ala  Thr Ala Trp Arg Ala  Leu Leu Ala Ser Asn  Thr Ser Tyr 
    1175                 1180                 1185             


Ala Leu  Leu Trp Asn Leu Leu  Glu Gly Arg Val Ala  Leu Glu Thr 
    1190                 1195                 1200             


Gln Arg  Asp Leu Glu Asp Arg  Tyr Gln Glu Val Gln  Ala Ala Gln 
    1205                 1210                 1215             


Lys Ala  Leu Arg Thr Ala Val  Ala Glu Val Leu Pro  Glu Ala Glu 
    1220                 1225                 1230             


Ser Val  Leu Ala Thr Val Gln  Gln Val Gly Ala Asp  Thr Ala Pro 
    1235                 1240                 1245             


Tyr Leu  Ala Leu Leu Ala Ser  Pro Gly Ala Leu Pro  Gln Lys Ser 
    1250                 1255                 1260             


Arg Ala  Glu Asp Leu Gly Leu  Lys Ala Lys Ala Leu  Glu Lys Thr 
    1265                 1270                 1275             


Val Ala  Ser Trp Gln His Met  Ala Thr Glu Ala Ala  Arg Thr Leu 
    1280                 1285                 1290             


Gln Thr  Ala Ala Gln Ala Thr  Leu Arg Gln Thr Glu  Pro Leu Thr 
    1295                 1300                 1305             


Lys Leu  His Gln Glu Ala Arg  Ala Ala Leu Thr Gln  Ala Ser Ser 
    1310                 1315                 1320             


Ser Val  Gln Ala Ala Thr Val  Thr Val Met Gly Ala  Arg Thr Leu 
    1325                 1330                 1335             


Leu Ala  Asp Leu Glu Gly Met  Lys Leu Gln Phe Pro  Arg Pro Lys 
    1340                 1345                 1350             


Asp Gln  Ala Ala Leu Gln Arg  Lys Ala Asp Ser Val  Ser Asp Arg 
    1355                 1360                 1365             


Leu Leu  Ala Asp Thr Arg Lys  Lys Thr Lys Gln Ala  Glu Arg Met 
    1370                 1375                 1380             


Leu Gly  Asn Ala Ala Pro Leu  Ser Ser Ser Ala Lys  Lys Lys Gly 
    1385                 1390                 1395             


Arg Glu  Ala Glu Val Leu Ala  Lys Asp Ser Ala Lys  Leu Ala Lys 
    1400                 1405                 1410             


Ala Leu  Leu Arg Glu Arg Lys  Gln Ala His Arg Arg  Ala Ser Arg 
    1415                 1420                 1425             


Leu Thr  Ser Gln Thr Gln Ala  Thr Leu Gln Gln Ala  Ser Gln Gln 
    1430                 1435                 1440             


Val Leu  Ala Ser Glu Ala Arg  Arg Gln Glu Leu Glu  Glu Ala Glu 
    1445                 1450                 1455             


Arg Val  Gly Ala Gly Leu Ser  Glu Met Glu Gln Gln  Ile Arg Glu 
    1460                 1465                 1470             


Ser Arg  Ile Ser Leu Glu Lys  Asp Ile Glu Thr Leu  Ser Glu Leu 
    1475                 1480                 1485             


Leu Ala  Arg Leu Gly Ser Leu  Asp Thr His Gln Ala  Pro Ala Gln 
    1490                 1495                 1500             


Ala Leu  Asn Glu Thr Gln Trp  Ala Leu Glu Arg Leu  Arg Leu Gln 
    1505                 1510                 1515             


Leu Gly  Ser Pro Gly Ser Leu  Gln Arg Lys Leu Ser  Leu Leu Glu 
    1520                 1525                 1530             


Gln Glu  Ser Gln Gln Gln Glu  Leu Gln Ile Gln Gly  Phe Glu Ser 
    1535                 1540                 1545             


Asp Leu  Ala Glu Ile Arg Ala  Asp Lys Gln Asn Leu  Glu Ala Ile 
    1550                 1555                 1560             


Leu His  Ser Leu Pro Glu Asn  Cys Ala Ser Trp Gln  
    1565                 1570                 1575 


<210>  7697
<211>  257
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7697

Xaa Thr Leu Gln Thr Ala Ala Gln Ala Thr Leu Arg Gln Thr Glu Pro 
1               5                   10                  15      


Leu Thr Lys Leu His Gln Glu Ala Arg Ala Ala Leu Thr Gln Ala Ser 
            20                  25                  30          


Ser Ser Val Gln Ala Ala Thr Val Thr Val Met Gly Ala Arg Thr Leu 
        35                  40                  45              


Leu Ala Asp Leu Glu Asp Thr Arg Lys Lys Thr Lys Gln Ala Glu Arg 
    50                  55                  60                  


Met Leu Gly Asn Ala Ala Pro Leu Ser Ser Ser Ala Lys Lys Lys Gly 
65                  70                  75                  80  


Arg Glu Ala Glu Val Leu Ala Lys Asp Ser Ala Lys Leu Ala Lys Ala 
                85                  90                  95      


Leu Leu Arg Glu Arg Lys Gln Ala His Arg Arg Ala Ser Arg Leu Thr 
            100                 105                 110         


Ser Gln Thr Gln Ala Thr Leu Gln Gln Ala Ser Gln Gln Val Leu Ala 
        115                 120                 125             


Ser Glu Ala Arg Arg Gln Glu Leu Glu Glu Ala Glu Arg Val Gly Ala 
    130                 135                 140                 


Gly Leu Ser Glu Met Glu Gln Gln Ile Arg Glu Ser Arg Ile Ser Leu 
145                 150                 155                 160 


Glu Lys Asp Ile Glu Thr Leu Ser Glu Leu Leu Ala Arg Leu Gly Ser 
                165                 170                 175     


Leu Asp Thr His Gln Ala Pro Ala Gln Ala Leu Asn Glu Thr Gln Trp 
            180                 185                 190         


Ala Leu Glu Arg Leu Arg Leu Gln Leu Gly Ser Pro Gly Ser Leu Gln 
        195                 200                 205             


Arg Lys Leu Ser Leu Leu Glu Gln Glu Ser Gln Gln Gln Glu Leu Gln 
    210                 215                 220                 


Ile Gln Gly Phe Glu Ser Asp Leu Ala Glu Ile Arg Ala Asp Lys Gln 
225                 230                 235                 240 


Asn Leu Glu Ala Ile Leu His Ser Leu Pro Glu Asn Cys Ala Ser Trp 
                245                 250                 255     


Gln 
    


<210>  7698
<211>  180
<212>  PRT
<213>  Homo Sapiens

<400>  7698

Met Pro Arg Gln Leu Ser Ala Ala Ala Ala Leu Phe Ala Ser Leu Ala 
1               5                   10                  15      


Val Ile Leu His Asp Gly Ser Gln Met Arg Ala Lys Ala Phe Pro Glu 
            20                  25                  30          


Thr Arg Asp Tyr Ser Gln Pro Thr Ala Ala Ala Thr Val Gln Asp Ile 
        35                  40                  45              


Lys Lys Pro Val Gln Gln Pro Ala Lys Gln Ala Pro His Gln Thr Leu 
    50                  55                  60                  


Ala Ala Arg Phe Met Asp Gly His Ile Thr Phe Gln Thr Ala Ala Thr 
65                  70                  75                  80  


Val Lys Ile Pro Thr Thr Thr Pro Ala Thr Thr Lys Asn Thr Ala Thr 
                85                  90                  95      


Thr Ser Pro Ile Thr Tyr Thr Leu Val Thr Thr Gln Ala Thr Pro Asn 
            100                 105                 110         


Asn Ser His Thr Ala Pro Pro Val Thr Glu Val Thr Val Gly Pro Ser 
        115                 120                 125             


Leu Ala Pro Tyr Ser Leu Pro Pro Thr Ile Thr Pro Pro Ala His Thr 
    130                 135                 140                 


Thr Gly Thr Ser Ser Ser Thr Val Ser His Thr Thr Gly Asn Thr Thr 
145                 150                 155                 160 


Gln Pro Ser Asn Gln Thr Thr Leu Pro Ala Thr Leu Ser Ile Ala Leu 
                165                 170                 175     


His Lys Ser Thr 
            180 


<210>  7699
<211>  416
<212>  PRT
<213>  Homo Sapiens

<400>  7699

Met Pro Arg Gln Leu Ser Ala Ala Ala Ala Leu Phe Ala Ser Leu Ala 
1               5                   10                  15      


Val Ile Leu His Asp Gly Ser Gln Met Arg Ala Lys Ala Phe Pro Glu 
            20                  25                  30          


Thr Arg Asp Tyr Ser Gln Pro Thr Ala Ala Ala Thr Val Gln Asp Ile 
        35                  40                  45              


Lys Lys Pro Val Gln Gln Pro Ala Lys Gln Ala Pro His Gln Thr Leu 
    50                  55                  60                  


Ala Ala Arg Phe Met Asp Gly His Ile Thr Phe Gln Thr Ala Ala Thr 
65                  70                  75                  80  


Val Lys Ile Pro Thr Thr Thr Pro Ala Thr Thr Lys Asn Thr Ala Thr 
                85                  90                  95      


Thr Ser Pro Ile Thr Tyr Thr Leu Val Thr Thr Gln Ala Thr Pro Asn 
            100                 105                 110         


Asn Ser His Thr Ala Pro Pro Val Thr Glu Val Thr Val Gly Pro Ser 
        115                 120                 125             


Leu Ala Pro Tyr Ser Leu Pro Pro Thr Ile Thr Pro Pro Ala His Thr 
    130                 135                 140                 


Thr Gly Thr Ser Ser Ser Thr Val Ser His Thr Thr Gly Asn Thr Thr 
145                 150                 155                 160 


Gln Pro Ser Asn Gln Thr Thr Leu Pro Ala Thr Leu Ser Ile Ala Leu 
                165                 170                 175     


His Lys Ser Thr Thr Gly Gln Lys Pro Val Gln Pro Thr His Ala Pro 
            180                 185                 190         


Gly Thr Thr Ala Ala Ala His Asn Thr Thr Arg Thr Ala Ala Pro Ala 
        195                 200                 205             


Ser Thr Val Pro Gly Pro Thr Leu Ala Pro Gln Pro Ser Ser Val Lys 
    210                 215                 220                 


Thr Gly Ile Tyr Gln Val Leu Asn Gly Ser Arg Leu Cys Ile Lys Ala 
225                 230                 235                 240 


Glu Met Gly Ile Gln Leu Ile Val Gln Asp Lys Glu Ser Val Phe Ser 
                245                 250                 255     


Pro Arg Arg Tyr Phe Asn Ile Asp Pro Asn Ala Thr Gln Ala Ser Gly 
            260                 265                 270         


Asn Cys Gly Thr Arg Lys Ser Asn Leu Leu Leu Asn Phe Gln Gly Gly 
        275                 280                 285             


Phe Val Asn Leu Thr Phe Thr Lys Asp Glu Glu Ser Tyr Tyr Ile Ser 
    290                 295                 300                 


Glu Val Gly Ala Tyr Leu Thr Val Ser Asp Pro Glu Thr Ile Tyr Gln 
305                 310                 315                 320 


Gly Ile Lys His Ala Val Val Met Phe Gln Thr Ala Val Gly His Ser 
                325                 330                 335     


Phe Lys Cys Val Ser Glu Gln Ser Leu Gln Leu Ser Ala His Leu Gln 
            340                 345                 350         


Val Lys Thr Thr Asp Val Gln Leu Gln Ala Phe Asp Phe Glu Asp Asp 
        355                 360                 365             


His Phe Gly Asn Val Asp Glu Cys Ser Ser Asp Tyr Thr Ile Val Leu 
    370                 375                 380                 


Pro Val Ile Gly Ala Ile Val Val Gly Leu Cys Leu Met Gly Met Gly 
385                 390                 395                 400 


Val Tyr Lys Ile Arg Leu Arg Cys Gln Ser Ser Gly Tyr Gln Arg Ile 
                405                 410                 415     


<210>  7700
<211>  143
<212>  PRT
<213>  Homo Sapiens

<400>  7700

Met Arg Ala Lys Ala Phe Pro Glu Thr Arg Asp Tyr Ser Gln Pro Thr 
1               5                   10                  15      


Ala Ala Ala Thr Val Gln Asp Ile Lys Lys Pro Val Gln Gln Pro Ala 
            20                  25                  30          


Lys Gln Ala Pro His Gln Thr Leu Ala Ala Arg Phe Met Asp Gly His 
        35                  40                  45              


Ile Thr Phe Gln Thr Ala Ala Thr Val Lys Ile Pro Thr Thr Thr Pro 
    50                  55                  60                  


Ala Thr Thr Lys Asn Thr Ala Thr Thr Ser Pro Ile Thr Tyr Thr Leu 
65                  70                  75                  80  


Val Thr Thr Gln Ala Thr Pro Asn Asn Ser His Thr Ala Pro Pro Val 
                85                  90                  95      


Thr Glu Val Thr Val Gly Pro Ser Leu Ala Pro Tyr Ser Leu Pro Pro 
            100                 105                 110         


Thr Ile Thr Pro Pro Ala His Thr Thr Gly Thr Ser Ser Ser Thr Val 
        115                 120                 125             


Ser His Thr Thr Gly Asn Thr Thr Gln Pro Ser Asn Gln Thr Thr 
    130                 135                 140             


<210>  7701
<211>  392
<212>  PRT
<213>  Homo Sapiens

<400>  7701

Met Arg Ala Lys Ala Phe Pro Glu Thr Arg Asp Tyr Ser Gln Pro Thr 
1               5                   10                  15      


Ala Ala Ala Thr Val Gln Asp Ile Lys Lys Pro Val Gln Gln Pro Ala 
            20                  25                  30          


Lys Gln Ala Pro His Gln Thr Leu Ala Ala Arg Phe Met Asp Gly His 
        35                  40                  45              


Ile Thr Phe Gln Thr Ala Ala Thr Val Lys Ile Pro Thr Thr Thr Pro 
    50                  55                  60                  


Ala Thr Thr Lys Asn Thr Ala Thr Thr Ser Pro Ile Thr Tyr Thr Leu 
65                  70                  75                  80  


Val Thr Thr Gln Ala Thr Pro Asn Asn Ser His Thr Ala Pro Pro Val 
                85                  90                  95      


Thr Glu Val Thr Val Gly Pro Ser Leu Ala Pro Tyr Ser Leu Pro Pro 
            100                 105                 110         


Thr Ile Thr Pro Pro Ala His Thr Thr Gly Thr Ser Ser Ser Thr Val 
        115                 120                 125             


Ser His Thr Thr Gly Asn Thr Thr Gln Pro Ser Asn Gln Thr Thr Leu 
    130                 135                 140                 


Pro Ala Thr Leu Ser Ile Ala Leu His Lys Ser Thr Thr Gly Gln Lys 
145                 150                 155                 160 


Pro Val Gln Pro Thr His Ala Pro Gly Thr Thr Ala Ala Ala His Asn 
                165                 170                 175     


Thr Thr Arg Thr Ala Ala Pro Ala Ser Thr Val Pro Gly Pro Thr Leu 
            180                 185                 190         


Ala Pro Gln Pro Ser Ser Val Lys Thr Gly Ile Tyr Gln Val Leu Asn 
        195                 200                 205             


Gly Ser Arg Leu Cys Ile Lys Ala Glu Met Gly Ile Gln Leu Ile Val 
    210                 215                 220                 


Gln Asp Lys Glu Ser Val Phe Ser Pro Arg Arg Tyr Phe Asn Ile Asp 
225                 230                 235                 240 


Pro Asn Ala Thr Gln Ala Ser Gly Asn Cys Gly Thr Arg Lys Ser Asn 
                245                 250                 255     


Leu Leu Leu Asn Phe Gln Gly Gly Phe Val Asn Leu Thr Phe Thr Lys 
            260                 265                 270         


Asp Glu Glu Ser Tyr Tyr Ile Ser Glu Val Gly Ala Tyr Leu Thr Val 
        275                 280                 285             


Ser Asp Pro Glu Thr Ile Tyr Gln Gly Ile Lys His Ala Val Val Met 
    290                 295                 300                 


Phe Gln Thr Ala Val Gly His Ser Phe Lys Cys Val Ser Glu Gln Ser 
305                 310                 315                 320 


Leu Gln Leu Ser Ala His Leu Gln Val Lys Thr Thr Asp Val Gln Leu 
                325                 330                 335     


Gln Ala Phe Asp Phe Glu Asp Asp His Phe Gly Asn Val Asp Glu Cys 
            340                 345                 350         


Ser Ser Asp Tyr Thr Ile Val Leu Pro Val Ile Gly Ala Ile Val Val 
        355                 360                 365             


Gly Leu Cys Leu Met Gly Met Gly Val Tyr Lys Ile Arg Leu Arg Cys 
    370                 375                 380                 


Gln Ser Ser Gly Tyr Gln Arg Ile 
385                 390         


<210>  7702
<211>  690
<212>  PRT
<213>  Homo Sapiens

<400>  7702

Met Leu Pro Arg Gly Arg Pro Arg Ala Leu Gly Ala Ala Ala Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gly Phe Leu Leu Phe Asp Gly Arg Leu Arg 
            20                  25                  30          


Arg Ala Ala Ala Leu Asp Gly Asp Pro Gly Ala Gly Pro Gly Asp His 
        35                  40                  45              


Asn Arg Ser Asp Cys Gly Pro Gln Pro Pro Pro Pro Pro Lys Cys Glu 
    50                  55                  60                  


Leu Leu His Val Ala Ile Val Cys Ala Gly His Asn Ser Ser Arg Asp 
65                  70                  75                  80  


Val Ile Thr Leu Val Lys Ser Met Leu Phe Tyr Arg Lys Asn Pro Leu 
                85                  90                  95      


His Leu His Leu Val Thr Asp Ala Val Ala Arg Asn Ile Leu Glu Thr 
            100                 105                 110         


Leu Phe His Thr Trp Met Val Pro Ala Val Arg Val Ser Phe Tyr His 
        115                 120                 125             


Ala Asp Gln Leu Lys Pro Gln Val Ser Trp Ile Pro Asn Lys His Tyr 
    130                 135                 140                 


Ser Gly Leu Tyr Gly Leu Met Lys Leu Val Leu Pro Ser Ala Leu Pro 
145                 150                 155                 160 


Ala Glu Leu Ala Arg Val Ile Val Leu Asp Thr Asp Val Thr Phe Ala 
                165                 170                 175     


Ser Asp Ile Ser Glu Leu Trp Ala Leu Phe Ala His Phe Ser Asp Thr 
            180                 185                 190         


Gln Ala Ile Gly Leu Val Glu Asn Gln Ser Asp Trp Tyr Leu Gly Asn 
        195                 200                 205             


Leu Trp Lys Asn His Arg Pro Trp Pro Ala Leu Gly Arg Gly Phe Asn 
    210                 215                 220                 


Thr Gly Val Ile Leu Leu Arg Leu Asp Arg Leu Arg Gln Ala Gly Trp 
225                 230                 235                 240 


Glu Gln Met Trp Arg Leu Thr Ala Arg Arg Glu Leu Leu Ser Leu Pro 
                245                 250                 255     


Ala Thr Ser Leu Ala Asp Gln Asp Ile Phe Asn Ala Val Ile Lys Glu 
            260                 265                 270         


His Pro Gly Leu Val Gln Arg Leu Pro Cys Val Trp Asn Val Gln Leu 
        275                 280                 285             


Ser Asp His Thr Leu Ala Glu Arg Cys Tyr Ser Glu Ala Ser Asp Leu 
    290                 295                 300                 


Lys Val Ile His Trp Asn Ser Pro Lys Lys Leu Arg Val Lys Asn Lys 
305                 310                 315                 320 


His Val Glu Phe Phe Arg Asn Phe Tyr Leu Thr Phe Leu Glu Tyr Asp 
                325                 330                 335     


Gly Asn Leu Leu Arg Arg Glu Leu Phe Val Cys Pro Ser Gln Pro Pro 
            340                 345                 350         


Pro Gly Ala Glu Gln Leu Gln Gln Ala Leu Ala Gln Leu Asp Glu Glu 
        355                 360                 365             


Asp Pro Cys Phe Glu Phe Arg Gln Gln Gln Leu Thr Val His Arg Val 
    370                 375                 380                 


His Val Thr Phe Leu Pro His Glu Pro Pro Pro Pro Arg Pro His Asp 
385                 390                 395                 400 


Val Thr Leu Val Ala Gln Leu Ser Met Asp Arg Leu Gln Met Leu Glu 
                405                 410                 415     


Ala Leu Cys Arg His Trp Pro Gly Pro Met Ser Leu Ala Leu Tyr Leu 
            420                 425                 430         


Thr Asp Ala Glu Ala Gln Gln Phe Leu His Phe Val Glu Ala Ser Pro 
        435                 440                 445             


Val Leu Ala Ala Arg Gln Asp Val Ala Tyr His Val Val Tyr Arg Glu 
    450                 455                 460                 


Gly Pro Leu Tyr Pro Val Asn Gln Leu Arg Asn Val Ala Leu Ala Gln 
465                 470                 475                 480 


Ala Leu Thr Pro Tyr Val Phe Leu Ser Asp Ile Asp Phe Leu Pro Ala 
                485                 490                 495     


Tyr Ser Leu Tyr Asp Tyr Leu Arg Ala Ser Ile Glu Gln Leu Gly Leu 
            500                 505                 510         


Gly Ser Arg Arg Lys Ala Ala Leu Val Val Pro Ala Phe Glu Thr Leu 
        515                 520                 525             


Arg Tyr Arg Phe Ser Phe Pro His Ser Lys Val Glu Leu Leu Ala Leu 
    530                 535                 540                 


Leu Asp Ala Gly Thr Leu Tyr Thr Phe Arg Tyr His Glu Trp Pro Arg 
545                 550                 555                 560 


Gly His Ala Pro Thr Asp Tyr Ala Arg Trp Arg Glu Ala Gln Ala Pro 
                565                 570                 575     


Tyr Arg Val Gln Trp Ala Ala Asn Tyr Glu Pro Tyr Val Val Val Pro 
            580                 585                 590         


Arg Asp Cys Pro Arg Tyr Asp Pro Arg Phe Val Gly Phe Gly Trp Asn 
        595                 600                 605             


Lys Val Ala His Ile Val Glu Leu Asp Ala Gln Glu Tyr Glu Leu Leu 
    610                 615                 620                 


Val Leu Pro Glu Ala Phe Thr Ile His Leu Pro His Ala Pro Ser Leu 
625                 630                 635                 640 


Asp Ile Ser Arg Phe Arg Ser Ser Pro Thr Tyr Arg Asp Cys Leu Gln 
                645                 650                 655     


Ala Leu Lys Asp Glu Phe His Gln Asp Leu Ser Arg His His Gly Ala 
            660                 665                 670         


Ala Ala Leu Lys Tyr Leu Pro Ala Leu Gln Gln Pro Gln Ser Pro Ala 
        675                 680                 685             


Arg Gly 
    690 


<210>  7703
<211>  721
<212>  PRT
<213>  Homo Sapiens

<400>  7703

Met Leu Pro Arg Gly Arg Pro Arg Ala Leu Gly Ala Ala Ala Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gly Phe Leu Leu Phe Gly Gly Asp Leu Gly 
            20                  25                  30          


Cys Glu Arg Arg Glu Pro Gly Gly Arg Ala Gly Ala Pro Gly Cys Phe 
        35                  40                  45              


Pro Gly Pro Leu Met Pro Arg Val Pro Pro Asp Gly Arg Leu Arg Arg 
    50                  55                  60                  


Ala Ala Ala Leu Asp Gly Asp Pro Gly Ala Gly Pro Gly Asp His Asn 
65                  70                  75                  80  


Arg Ser Asp Cys Gly Pro Gln Pro Pro Pro Pro Pro Lys Cys Glu Leu 
                85                  90                  95      


Leu His Val Ala Ile Val Cys Ala Gly His Asn Ser Ser Arg Asp Val 
            100                 105                 110         


Ile Thr Leu Val Lys Ser Met Leu Phe Tyr Arg Lys Asn Pro Leu His 
        115                 120                 125             


Leu His Leu Val Thr Asp Ala Val Ala Arg Asn Ile Leu Glu Thr Leu 
    130                 135                 140                 


Phe His Thr Trp Met Val Pro Ala Val Arg Val Ser Phe Tyr His Ala 
145                 150                 155                 160 


Asp Gln Leu Lys Pro Gln Val Ser Trp Ile Pro Asn Lys His Tyr Ser 
                165                 170                 175     


Gly Leu Tyr Gly Leu Met Lys Leu Val Leu Pro Ser Ala Leu Pro Ala 
            180                 185                 190         


Glu Leu Ala Arg Val Ile Val Leu Asp Thr Asp Val Thr Phe Ala Ser 
        195                 200                 205             


Asp Ile Ser Glu Leu Trp Ala Leu Phe Ala His Phe Ser Asp Thr Gln 
    210                 215                 220                 


Ala Ile Gly Leu Val Glu Asn Gln Ser Asp Trp Tyr Leu Gly Asn Leu 
225                 230                 235                 240 


Trp Lys Asn His Arg Pro Trp Pro Ala Leu Gly Arg Gly Phe Asn Thr 
                245                 250                 255     


Gly Val Ile Leu Leu Arg Leu Asp Arg Leu Arg Gln Ala Gly Trp Glu 
            260                 265                 270         


Gln Met Trp Arg Leu Thr Ala Arg Arg Glu Leu Leu Ser Leu Pro Ala 
        275                 280                 285             


Thr Ser Leu Ala Asp Gln Asp Ile Phe Asn Ala Val Ile Lys Glu His 
    290                 295                 300                 


Pro Gly Leu Val Gln Arg Leu Pro Cys Val Trp Asn Val Gln Leu Ser 
305                 310                 315                 320 


Asp His Thr Leu Ala Glu Arg Cys Tyr Ser Glu Ala Ser Asp Leu Lys 
                325                 330                 335     


Val Ile His Trp Asn Ser Pro Lys Lys Leu Arg Val Lys Asn Lys His 
            340                 345                 350         


Val Glu Phe Phe Arg Asn Phe Tyr Leu Thr Phe Leu Glu Tyr Asp Gly 
        355                 360                 365             


Asn Leu Leu Arg Arg Glu Leu Phe Val Cys Pro Ser Gln Pro Pro Pro 
    370                 375                 380                 


Gly Ala Glu Gln Leu Gln Gln Ala Leu Ala Gln Leu Asp Glu Glu Asp 
385                 390                 395                 400 


Pro Cys Phe Glu Phe Arg Gln Gln Gln Leu Thr Val His Arg Val His 
                405                 410                 415     


Val Thr Phe Leu Pro His Glu Pro Pro Pro Pro Arg Pro His Asp Val 
            420                 425                 430         


Thr Leu Val Ala Gln Leu Ser Met Asp Arg Leu Gln Met Leu Glu Ala 
        435                 440                 445             


Leu Cys Arg His Trp Pro Gly Pro Met Ser Leu Ala Leu Tyr Leu Thr 
    450                 455                 460                 


Asp Ala Glu Ala Gln Gln Phe Leu His Phe Val Glu Ala Ser Pro Val 
465                 470                 475                 480 


Leu Ala Ala Arg Gln Asp Val Ala Tyr His Val Val Tyr Arg Glu Gly 
                485                 490                 495     


Pro Leu Tyr Pro Val Asn Gln Leu Arg Asn Val Ala Leu Ala Gln Ala 
            500                 505                 510         


Leu Thr Pro Tyr Val Phe Leu Ser Asp Ile Asp Phe Leu Pro Ala Tyr 
        515                 520                 525             


Ser Leu Tyr Asp Tyr Leu Arg Ala Ser Ile Glu Gln Leu Gly Leu Gly 
    530                 535                 540                 


Ser Arg Arg Lys Ala Ala Leu Val Val Pro Ala Phe Glu Thr Leu Arg 
545                 550                 555                 560 


Tyr Arg Phe Ser Phe Pro His Ser Lys Val Glu Leu Leu Ala Leu Leu 
                565                 570                 575     


Asp Ala Gly Thr Leu Tyr Thr Phe Arg Tyr His Glu Trp Pro Arg Gly 
            580                 585                 590         


His Ala Pro Thr Asp Tyr Ala Arg Trp Arg Glu Ala Gln Ala Pro Tyr 
        595                 600                 605             


Arg Val Gln Trp Ala Ala Asn Tyr Glu Pro Tyr Val Val Val Pro Arg 
    610                 615                 620                 


Asp Cys Pro Arg Tyr Asp Pro Arg Phe Val Gly Phe Gly Trp Asn Lys 
625                 630                 635                 640 


Val Ala His Ile Val Glu Leu Asp Ala Gln Glu Tyr Glu Leu Leu Val 
                645                 650                 655     


Leu Pro Glu Ala Phe Thr Ile His Leu Pro His Ala Pro Ser Leu Asp 
            660                 665                 670         


Ile Ser Arg Phe Arg Ser Ser Pro Thr Tyr Arg Asp Cys Leu Gln Ala 
        675                 680                 685             


Leu Lys Asp Glu Phe His Gln Asp Leu Ser Arg His His Gly Ala Ala 
    690                 695                 700                 


Ala Leu Lys Tyr Leu Pro Ala Leu Gln Gln Pro Gln Ser Pro Ala Arg 
705                 710                 715                 720 


Gly 
    


<210>  7704
<211>  721
<212>  PRT
<213>  Homo Sapiens

<400>  7704

Met Leu Pro Arg Gly Arg Pro Arg Ala Leu Gly Ala Ala Ala Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gly Phe Leu Leu Phe Gly Gly Asp Leu Gly 
            20                  25                  30          


Cys Glu Arg Arg Glu Pro Gly Gly Arg Ala Gly Ala Pro Gly Cys Phe 
        35                  40                  45              


Pro Gly Pro Leu Met Pro Arg Val Pro Pro Asp Gly Arg Leu Arg Arg 
    50                  55                  60                  


Ala Ala Ala Leu Asp Gly Asp Pro Gly Ala Gly Pro Gly Asp His Asn 
65                  70                  75                  80  


Arg Ser Asp Cys Gly Pro Gln Pro Pro Pro Pro Pro Lys Cys Glu Leu 
                85                  90                  95      


Leu His Val Ala Ile Val Cys Ala Gly His Asn Ser Ser Arg Asp Val 
            100                 105                 110         


Ile Thr Leu Val Lys Ser Met Leu Phe Tyr Arg Lys Asn Pro Leu His 
        115                 120                 125             


Leu His Leu Val Thr Asp Ala Val Ala Arg Asn Ile Leu Glu Thr Leu 
    130                 135                 140                 


Phe His Thr Trp Met Val Pro Ala Val Arg Val Ser Phe Tyr His Ala 
145                 150                 155                 160 


Asp Gln Leu Lys Pro Gln Val Ser Trp Ile Pro Asn Lys His Tyr Ser 
                165                 170                 175     


Gly Leu Tyr Gly Leu Met Lys Leu Val Leu Pro Ser Ala Leu Pro Ala 
            180                 185                 190         


Glu Leu Ala Arg Val Ile Val Leu Asp Thr Asp Val Thr Phe Ala Ser 
        195                 200                 205             


Asp Ile Ser Glu Leu Trp Ala Leu Phe Ala His Phe Ser Asp Thr Gln 
    210                 215                 220                 


Ala Ile Gly Leu Val Glu Asn Gln Ser Asp Trp Tyr Leu Gly Asn Leu 
225                 230                 235                 240 


Trp Lys Asn His Arg Pro Trp Pro Ala Leu Gly Arg Gly Phe Asn Thr 
                245                 250                 255     


Gly Val Ile Leu Leu Arg Leu Asp Arg Leu Arg Gln Ala Gly Trp Glu 
            260                 265                 270         


Gln Met Trp Arg Leu Thr Ala Arg Arg Glu Leu Leu Ser Leu Pro Ala 
        275                 280                 285             


Thr Ser Leu Ala Asp Gln Asp Ile Phe Asn Ala Val Ile Lys Glu His 
    290                 295                 300                 


Pro Gly Leu Val Gln Arg Leu Pro Cys Val Trp Asn Val Gln Leu Ser 
305                 310                 315                 320 


Asp His Thr Leu Ala Glu Arg Cys Tyr Ser Glu Ala Ser Asp Leu Lys 
                325                 330                 335     


Val Ile His Trp Asn Ser Pro Lys Lys Leu Arg Val Lys Asn Lys His 
            340                 345                 350         


Val Glu Phe Phe Arg Asn Phe Tyr Leu Thr Phe Leu Glu Tyr Asp Gly 
        355                 360                 365             


Asn Leu Leu Arg Arg Glu Leu Phe Val Cys Pro Ser Gln Pro Pro Pro 
    370                 375                 380                 


Gly Ala Glu Gln Leu Gln Gln Ala Leu Ala Gln Leu Asp Glu Glu Asp 
385                 390                 395                 400 


Pro Cys Phe Glu Phe Arg Gln Gln Gln Leu Thr Val His Arg Val His 
                405                 410                 415     


Val Thr Phe Leu Pro His Glu Pro Pro Pro Pro Arg Pro His Asp Val 
            420                 425                 430         


Thr Leu Val Ala Gln Leu Ser Met Asp Arg Leu Gln Met Leu Glu Ala 
        435                 440                 445             


Leu Cys Arg His Trp Pro Gly Pro Met Ser Leu Ala Leu Tyr Leu Thr 
    450                 455                 460                 


Asp Ala Glu Ala Gln Gln Phe Leu His Phe Val Glu Ala Ser Pro Val 
465                 470                 475                 480 


Leu Ala Ala Arg Gln Asp Val Ala Tyr His Val Val Tyr Arg Glu Gly 
                485                 490                 495     


Pro Leu Tyr Pro Val Asn Gln Leu Arg Asn Val Ala Leu Ala Gln Ala 
            500                 505                 510         


Leu Thr Pro Tyr Val Phe Leu Ser Asp Ile Asp Phe Leu Pro Ala Tyr 
        515                 520                 525             


Ser Leu Tyr Asp Tyr Leu Arg Ala Ser Ile Glu Gln Leu Gly Leu Gly 
    530                 535                 540                 


Ser Arg Arg Lys Ala Ala Leu Val Val Pro Ala Phe Glu Thr Leu Arg 
545                 550                 555                 560 


Tyr Arg Phe Ser Phe Pro His Ser Lys Val Glu Leu Leu Ala Leu Leu 
                565                 570                 575     


Asp Ala Gly Thr Leu Tyr Thr Phe Arg Tyr His Glu Trp Pro Arg Gly 
            580                 585                 590         


His Ala Pro Thr Asp Tyr Ala Arg Trp Arg Glu Ala Gln Ala Pro Tyr 
        595                 600                 605             


Arg Val Gln Trp Ala Ala Asn Tyr Glu Pro Tyr Val Val Val Pro Arg 
    610                 615                 620                 


Asp Cys Pro Arg Tyr Asp Pro Arg Phe Val Gly Phe Gly Trp Asn Lys 
625                 630                 635                 640 


Val Ala His Ile Val Glu Leu Asp Ala Gln Glu Tyr Glu Leu Leu Val 
                645                 650                 655     


Leu Pro Glu Ala Phe Thr Ile His Leu Pro His Ala Pro Ser Leu Asp 
            660                 665                 670         


Ile Ser Arg Phe Arg Ser Ser Pro Thr Tyr Arg Asp Cys Leu Gln Ala 
        675                 680                 685             


Leu Lys Asp Glu Phe His Gln Asp Leu Ser Arg His His Gly Ala Ala 
    690                 695                 700                 


Ala Leu Lys Tyr Leu Pro Ala Leu Gln Gln Pro Gln Ser Pro Ala Arg 
705                 710                 715                 720 


Gly 
    


<210>  7705
<211>  721
<212>  PRT
<213>  Homo Sapiens

<400>  7705

Met Leu Pro Arg Gly Arg Pro Arg Ala Leu Gly Ala Ala Ala Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gly Phe Leu Leu Phe Gly Gly Asp Leu Gly 
            20                  25                  30          


Cys Glu Arg Arg Glu Pro Gly Gly Arg Ala Gly Ala Pro Gly Cys Phe 
        35                  40                  45              


Pro Gly Pro Leu Met Pro Arg Val Pro Pro Asp Gly Arg Leu Arg Arg 
    50                  55                  60                  


Ala Ala Ala Leu Asp Gly Asp Pro Gly Ala Gly Pro Gly Asp His Asn 
65                  70                  75                  80  


Arg Ser Asp Cys Gly Pro Gln Pro Pro Pro Pro Pro Lys Cys Glu Leu 
                85                  90                  95      


Leu His Val Ala Ile Val Cys Ala Gly His Asn Ser Ser Arg Asp Val 
            100                 105                 110         


Ile Thr Leu Val Lys Ser Met Leu Phe Tyr Arg Lys Asn Pro Leu His 
        115                 120                 125             


Leu His Leu Val Thr Asp Ala Val Ala Arg Asn Ile Leu Glu Thr Leu 
    130                 135                 140                 


Phe His Thr Trp Met Val Pro Ala Val Arg Val Ser Phe Tyr His Ala 
145                 150                 155                 160 


Asp Gln Leu Lys Pro Gln Val Ser Trp Ile Pro Asn Lys His Tyr Ser 
                165                 170                 175     


Gly Leu Tyr Gly Leu Met Lys Leu Val Leu Pro Ser Ala Leu Pro Ala 
            180                 185                 190         


Glu Leu Ala Arg Val Ile Val Leu Asp Thr Asp Val Thr Phe Ala Ser 
        195                 200                 205             


Asp Ile Ser Glu Leu Trp Ala Leu Phe Ala His Phe Ser Asp Thr Gln 
    210                 215                 220                 


Ala Ile Gly Leu Val Glu Asn Gln Ser Asp Trp Tyr Leu Gly Asn Leu 
225                 230                 235                 240 


Trp Lys Asn His Arg Pro Trp Pro Ala Leu Gly Arg Gly Phe Asn Thr 
                245                 250                 255     


Gly Val Ile Leu Leu Arg Leu Asp Arg Leu Arg Gln Ala Gly Trp Glu 
            260                 265                 270         


Gln Met Trp Arg Leu Thr Ala Arg Arg Glu Leu Leu Ser Leu Pro Ala 
        275                 280                 285             


Thr Ser Leu Ala Asp Gln Asp Ile Phe Asn Ala Val Ile Lys Glu His 
    290                 295                 300                 


Pro Gly Leu Val Gln Arg Leu Pro Cys Val Trp Asn Val Gln Leu Ser 
305                 310                 315                 320 


Asp His Thr Leu Ala Glu Arg Cys Tyr Ser Glu Ala Ser Asp Leu Lys 
                325                 330                 335     


Val Ile His Trp Asn Ser Pro Lys Lys Leu Arg Val Lys Asn Lys His 
            340                 345                 350         


Val Glu Phe Phe Arg Asn Phe Tyr Leu Thr Phe Leu Glu Tyr Asp Gly 
        355                 360                 365             


Asn Leu Leu Arg Arg Glu Leu Phe Val Cys Pro Ser Gln Pro Pro Pro 
    370                 375                 380                 


Gly Ala Glu Gln Leu Gln Gln Ala Leu Ala Gln Leu Asp Glu Glu Asp 
385                 390                 395                 400 


Pro Cys Phe Glu Phe Arg Gln Gln Gln Leu Thr Val His Arg Val His 
                405                 410                 415     


Val Thr Phe Leu Pro His Glu Pro Pro Pro Pro Arg Pro His Asp Val 
            420                 425                 430         


Thr Leu Val Ala Gln Leu Ser Met Asp Arg Leu Gln Met Leu Glu Ala 
        435                 440                 445             


Leu Cys Arg His Trp Pro Gly Pro Met Ser Leu Ala Leu Tyr Leu Thr 
    450                 455                 460                 


Asp Ala Glu Ala Gln Gln Phe Leu His Phe Val Glu Ala Ser Pro Val 
465                 470                 475                 480 


Leu Ala Ala Arg Gln Asp Val Ala Tyr His Val Val Tyr Arg Glu Gly 
                485                 490                 495     


Pro Leu Tyr Pro Val Asn Gln Leu Arg Asn Val Ala Leu Ala Gln Ala 
            500                 505                 510         


Leu Thr Pro Tyr Val Phe Leu Ser Asp Ile Asp Phe Leu Pro Ala Tyr 
        515                 520                 525             


Ser Leu Tyr Asp Tyr Leu Arg Ala Ser Ile Glu Gln Leu Gly Leu Gly 
    530                 535                 540                 


Ser Arg Arg Lys Ala Ala Leu Val Val Pro Ala Phe Glu Thr Leu Arg 
545                 550                 555                 560 


Tyr Arg Phe Ser Phe Pro His Ser Lys Val Glu Leu Leu Ala Leu Leu 
                565                 570                 575     


Asp Ala Gly Thr Leu Tyr Thr Phe Arg Tyr His Glu Trp Pro Arg Gly 
            580                 585                 590         


His Ala Pro Thr Asp Tyr Ala Arg Trp Arg Glu Ala Gln Ala Pro Tyr 
        595                 600                 605             


Arg Val Gln Trp Ala Ala Asn Tyr Glu Pro Tyr Val Val Val Pro Arg 
    610                 615                 620                 


Asp Cys Pro Arg Tyr Asp Pro Arg Phe Val Gly Phe Gly Trp Asn Lys 
625                 630                 635                 640 


Val Ala His Ile Val Glu Leu Asp Ala Gln Glu Tyr Glu Leu Leu Val 
                645                 650                 655     


Leu Pro Glu Ala Phe Thr Ile His Leu Pro His Ala Pro Ser Leu Asp 
            660                 665                 670         


Ile Ser Arg Phe Arg Ser Ser Pro Thr Tyr Arg Asp Cys Leu Gln Ala 
        675                 680                 685             


Leu Lys Asp Glu Phe His Gln Asp Leu Ser Arg His His Gly Ala Ala 
    690                 695                 700                 


Ala Leu Lys Tyr Leu Pro Ala Leu Gln Gln Pro Gln Ser Pro Ala Arg 
705                 710                 715                 720 


Gly 
    


<210>  7706
<211>  158
<212>  PRT
<213>  Homo Sapiens

<400>  7706

Trp Asn Ser Pro Lys Lys Leu Arg Val Lys Asn Lys His Val Glu Phe 
1               5                   10                  15      


Phe Arg Asn Phe Tyr Leu Thr Phe Leu Glu Tyr Asp Gly Asn Leu Leu 
            20                  25                  30          


Arg Arg Glu Leu Phe Val Cys Pro Ser Gln Pro Pro Pro Gly Ala Glu 
        35                  40                  45              


Gln Leu Gln Gln Ala Leu Ala Gln Leu Asp Glu Glu Asp Pro Cys Phe 
    50                  55                  60                  


Glu Phe Arg Gln Gln Gln Leu Thr Val His Arg Val His Val Thr Phe 
65                  70                  75                  80  


Leu Pro His Glu Pro Pro Pro Pro Arg Pro His Asp Val Thr Leu Val 
                85                  90                  95      


Ala Gln Leu Ser Met Asp Arg Thr Trp Pro Thr Met Trp Cys Thr Val 
            100                 105                 110         


Arg Gly Pro Tyr Thr Pro Ser Thr Ser Phe Ala Thr Trp Pro Trp Pro 
        115                 120                 125             


Arg Pro Ser Arg Leu Thr Ser Ser Ser Val Thr Leu Thr Ser Cys Leu 
    130                 135                 140                 


Pro Ile Leu Ser Thr Thr Thr Ser Gly Pro Pro Leu Ser Ser 
145                 150                 155             


<210>  7707
<211>  109
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7707

Xaa Leu Leu Asp Ala Gly Thr Leu Tyr Thr Phe Arg Asn Met Ser Ser 
1               5                   10                  15      


Trp Cys Cys Pro Arg Pro Ser Pro Ser Ile Cys Pro Thr Leu Gln Ala 
            20                  25                  30          


Trp Thr Ser Pro Ala Ser Ala Pro Ala Pro Pro Ile Val Thr Ala Ser 
        35                  40                  45              


Arg Pro Ser Arg Thr Asn Ser Thr Arg Thr Cys Pro Ala Thr Met Gly 
    50                  55                  60                  


Leu Leu Pro Ser Asn Thr Ser Gln Pro Cys Ser Ser Pro Arg Ala Leu 
65                  70                  75                  80  


Pro Glu Ala Glu Ala Gly Pro Ala Leu Pro Leu Ile Leu Ala Leu Gly 
                85                  90                  95      


Arg His Gln Gly Asn Leu Pro Ser Ala Ile Pro Ala Ile 
            100                 105                 


<210>  7708
<211>  166
<212>  PRT
<213>  Homo Sapiens

<400>  7708

Ile Pro Arg Ser Pro Gln Pro Leu Gly Gly Ser His Arg Thr Pro Ser 
1               5                   10                  15      


Ser Arg Arg Asp Ser Asp Gly Ala Asn Ser Val Ala Ser Tyr Glu Asn 
            20                  25                  30          


Glu Glu Pro Ala Cys Glu Asp Ala Asp Glu Asp Glu Asp Asp Tyr His 
        35                  40                  45              


Asn Pro Gly Tyr Leu Val Val Leu Pro Asp Ser Thr Pro Ala Thr Ser 
    50                  55                  60                  


Thr Ala Ala Pro Ser Ala Pro Ala Leu Ser Thr Pro Gly Ile Arg Asp 
65                  70                  75                  80  


Ser Ala Phe Ser Met Glu Ser Ile Asp Asp Tyr Val Asn Val Pro Glu 
                85                  90                  95      


Ser Gly Glu Ser Ala Glu Ala Ser Leu Asp Gly Ser Arg Glu Tyr Val 
            100                 105                 110         


Asn Val Ser Gln Glu Leu His Pro Gly Ala Ala Lys Thr Glu Pro Val 
        115                 120                 125             


Glu Ala Glu Ser Val Leu Glu Pro Gly Leu Pro Gly Thr Ala Glu Leu 
    130                 135                 140                 


Gly Ser Trp Lys Trp Leu Trp Gly Pro His Met Ala Ser Cys Pro Cys 
145                 150                 155                 160 


Ser Ser Leu Thr Thr Ala 
                165     


<210>  7709
<211>  269
<212>  PRT
<213>  Homo Sapiens

<400>  7709

Met Glu Ala Thr Ala Ala Ser Trp Gln Val Ala Val Pro Val Leu Gly 
1               5                   10                  15      


Gly Ala Ser Arg Pro Leu Gly Pro Arg Gly Ala Ala Ser Leu Leu Arg 
            20                  25                  30          


Ala Pro Leu Gln Met Glu Glu Ala Ile Leu Val Pro Cys Val Leu Gly 
        35                  40                  45              


Leu Leu Leu Leu Pro Ile Leu Ala Met Leu Met Ala Leu Cys Val His 
    50                  55                  60                  


Cys His Arg Leu Pro Gly Ser Tyr Asp Ser Thr Ser Ser Asp Ser Leu 
65                  70                  75                  80  


Tyr Pro Arg Gly Ile Gln Phe Lys Arg Pro His Thr Val Ala Pro Trp 
                85                  90                  95      


Pro Pro Ala Tyr Pro Pro Val Thr Ser Tyr Pro Pro Leu Ser Gln Pro 
            100                 105                 110         


Asp Leu Leu Pro Ile Pro Arg Ser Pro Gln Pro Leu Gly Gly Ser His 
        115                 120                 125             


Arg Thr Pro Ser Ser Arg Arg Asp Ser Asp Gly Ala Asn Ser Val Ala 
    130                 135                 140                 


Ser Tyr Glu Asn Glu Glu Pro Ala Cys Glu Asp Ala Asp Glu Asp Glu 
145                 150                 155                 160 


Asp Asp Tyr His Asn Pro Gly Tyr Leu Val Val Leu Pro Asp Ser Thr 
                165                 170                 175     


Pro Ala Thr Ser Thr Ala Ala Pro Ser Ala Pro Ala Leu Ser Thr Pro 
            180                 185                 190         


Gly Ile Arg Asp Ser Ala Phe Ser Met Glu Ser Ile Asp Asp Tyr Val 
        195                 200                 205             


Asn Val Pro Glu Ser Gly Glu Ser Ala Glu Ala Ser Leu Asp Gly Ser 
    210                 215                 220                 


Arg Glu Tyr Val Asn Val Ser Gln Glu Leu His Pro Gly Ala Ala Lys 
225                 230                 235                 240 


Thr Glu Pro Ala Ala Leu Ser Ser Gln Glu Ala Glu Glu Val Glu Glu 
                245                 250                 255     


Glu Gly Ala Pro Asp Tyr Glu Asn Leu Gln Glu Leu Asn 
            260                 265                 


<210>  7710
<211>  85
<212>  PRT
<213>  Homo Sapiens

<400>  7710

Met Glu Glu Ala Ile Leu Val Pro Cys Val Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Ile Leu Ala Met Leu Met Ala Leu Cys Val His Cys His Arg Leu 
            20                  25                  30          


Pro Gly Ser Tyr Asp Ser Thr Ser Ser Asp Ser Leu Tyr Pro Arg Gly 
        35                  40                  45              


Ile Gln Phe Lys Arg Pro His Thr Val Ala Pro Trp Pro Pro Ala Tyr 
    50                  55                  60                  


Pro Pro Val Thr Ser Tyr Pro Pro Leu Ser Gln Pro Asp Leu Leu Pro 
65                  70                  75                  80  


Ile Pro His Asp Pro 
                85  


<210>  7711
<211>  85
<212>  PRT
<213>  Homo Sapiens

<400>  7711

Met Glu Glu Ala Ile Leu Val Pro Cys Val Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Ile Leu Ala Met Leu Met Ala Leu Cys Val His Cys His Arg Leu 
            20                  25                  30          


Pro Gly Ser Tyr Asp Ser Thr Ser Ser Asp Ser Leu Tyr Pro Arg Gly 
        35                  40                  45              


Ile Gln Phe Lys Arg Pro His Thr Val Ala Pro Trp Pro Pro Ala Tyr 
    50                  55                  60                  


Pro Pro Val Thr Ser Tyr Pro Pro Leu Ser Gln Pro Asp Leu Leu Pro 
65                  70                  75                  80  


Ile Pro His Asp Pro 
                85  


<210>  7712
<211>  233
<212>  PRT
<213>  Homo Sapiens

<400>  7712

Met Glu Glu Ala Ile Leu Val Pro Cys Val Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Ile Leu Ala Met Leu Met Ala Leu Cys Val His Cys His Arg Leu 
            20                  25                  30          


Pro Gly Ser Tyr Asp Ser Thr Ser Ser Asp Ser Leu Tyr Pro Arg Gly 
        35                  40                  45              


Ile Gln Phe Lys Arg Pro His Thr Val Ala Pro Trp Pro Pro Ala Tyr 
    50                  55                  60                  


Pro Pro Val Thr Ser Tyr Pro Pro Leu Ser Gln Pro Asp Leu Leu Pro 
65                  70                  75                  80  


Ile Pro Arg Ser Pro Gln Pro Leu Gly Gly Ser His Arg Thr Pro Ser 
                85                  90                  95      


Ser Arg Arg Asp Ser Asp Gly Ala Asn Ser Val Ala Ser Tyr Glu Asn 
            100                 105                 110         


Glu Glu Pro Ala Cys Glu Asp Ala Asp Glu Asp Glu Asp Asp Tyr His 
        115                 120                 125             


Asn Pro Gly Tyr Leu Val Val Leu Pro Asp Ser Thr Pro Ala Thr Ser 
    130                 135                 140                 


Thr Ala Ala Pro Ser Ala Pro Ala Leu Ser Thr Pro Gly Ile Arg Asp 
145                 150                 155                 160 


Ser Ala Phe Ser Met Glu Ser Ile Asp Asp Tyr Val Asn Val Pro Glu 
                165                 170                 175     


Ser Gly Glu Ser Ala Glu Ala Ser Leu Asp Gly Ser Arg Glu Tyr Val 
            180                 185                 190         


Asn Val Ser Gln Glu Leu His Pro Gly Ala Ala Lys Thr Glu Pro Ala 
        195                 200                 205             


Ala Leu Ser Ser Gln Glu Ala Glu Glu Val Glu Glu Glu Gly Ala Pro 
    210                 215                 220                 


Asp Tyr Glu Asn Leu Gln Glu Leu Asn 
225                 230             


<210>  7713
<211>  262
<212>  PRT
<213>  Homo Sapiens

<400>  7713

Met Glu Glu Ala Ile Leu Val Pro Cys Val Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Ile Leu Ala Met Leu Met Ala Leu Cys Val His Cys His Arg Leu 
            20                  25                  30          


Pro Gly Ser Tyr Asp Ser Thr Ser Ser Asp Ser Leu Tyr Pro Arg Gly 
        35                  40                  45              


Ile Gln Phe Lys Arg Pro His Thr Val Ala Pro Trp Pro Pro Ala Tyr 
    50                  55                  60                  


Pro Pro Val Thr Ser Tyr Pro Pro Leu Ser Gln Pro Asp Leu Leu Pro 
65                  70                  75                  80  


Ile Pro Arg Ser Pro Gln Pro Leu Gly Gly Ser His Arg Thr Pro Ser 
                85                  90                  95      


Ser Arg Arg Asp Ser Asp Gly Ala Asn Ser Val Ala Ser Tyr Glu Asn 
            100                 105                 110         


Glu Gly Ala Ser Gly Ile Arg Gly Ala Gln Ala Gly Trp Gly Val Trp 
        115                 120                 125             


Gly Pro Ser Trp Thr Arg Leu Thr Pro Val Ser Leu Pro Pro Glu Pro 
    130                 135                 140                 


Ala Cys Glu Asp Ala Asp Glu Asp Glu Asp Asp Tyr His Asn Pro Gly 
145                 150                 155                 160 


Tyr Leu Val Val Leu Pro Asp Ser Thr Pro Ala Thr Ser Thr Ala Ala 
                165                 170                 175     


Pro Ser Ala Pro Ala Leu Ser Thr Pro Gly Ile Arg Asp Ser Ala Phe 
            180                 185                 190         


Ser Met Glu Ser Ile Asp Asp Tyr Val Asn Val Pro Glu Ser Gly Glu 
        195                 200                 205             


Ser Ala Glu Ala Ser Leu Asp Gly Ser Arg Glu Tyr Val Asn Val Ser 
    210                 215                 220                 


Gln Glu Leu His Pro Gly Ala Ala Lys Thr Glu Pro Ala Ala Leu Ser 
225                 230                 235                 240 


Ser Gln Glu Ala Glu Glu Val Glu Glu Glu Gly Ala Pro Asp Tyr Glu 
                245                 250                 255     


Asn Leu Gln Glu Leu Asn 
            260         


<210>  7714
<211>  252
<212>  PRT
<213>  Homo Sapiens

<400>  7714

Met Glu Glu Ala Ile Leu Val Pro Cys Val Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Ile Leu Ala Met Leu Met Ala Leu Cys Val His Cys His Arg Leu 
            20                  25                  30          


Pro Gly Ser Tyr Asp Ser Thr Ser Ser Asp Ser Leu Tyr Pro Arg Gly 
        35                  40                  45              


Ile Gln Phe Lys Arg Pro His Thr Val Ala Pro Trp Pro Pro Ala Tyr 
    50                  55                  60                  


Pro Pro Val Thr Ser Tyr Pro Pro Leu Ser Gln Pro Asp Leu Leu Pro 
65                  70                  75                  80  


Ile Pro Arg Ser Pro Gln Pro Leu Arg Asp Ser Asp Gly Ala Asn Ser 
                85                  90                  95      


Val Ala Ser Tyr Glu Asn Glu Gly Ala Ser Gly Ile Arg Gly Ala Gln 
            100                 105                 110         


Ala Gly Trp Gly Val Trp Gly Pro Ser Trp Thr Arg Leu Thr Pro Val 
        115                 120                 125             


Ser Leu Pro Pro Glu Pro Ala Cys Glu Asp Ala Asp Glu Asp Glu Asp 
    130                 135                 140                 


Asp Tyr His Asn Pro Gly Tyr Leu Val Val Leu Pro Asp Ser Thr Pro 
145                 150                 155                 160 


Ala Thr Ser Thr Ala Ala Pro Ser Ala Pro Ala Leu Ser Thr Pro Gly 
                165                 170                 175     


Ile Arg Asp Ser Ala Phe Ser Met Glu Ser Ile Asp Asp Tyr Val Asn 
            180                 185                 190         


Val Pro Glu Ser Gly Glu Ser Ala Glu Ala Ser Leu Asp Gly Ser Arg 
        195                 200                 205             


Glu Tyr Val Asn Val Ser Gln Glu Leu His Pro Gly Ala Ala Lys Thr 
    210                 215                 220                 


Glu Pro Ala Ala Leu Ser Ser Gln Glu Ala Glu Glu Val Glu Glu Glu 
225                 230                 235                 240 


Gly Ala Pro Asp Tyr Glu Asn Leu Gln Glu Leu Asn 
                245                 250         


<210>  7715
<211>  232
<212>  PRT
<213>  Homo Sapiens

<400>  7715

Met Glu Glu Ala Ile Leu Val Pro Cys Val Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Ile Leu Ala Met Leu Met Ala Leu Cys Val His Cys His Arg Leu 
            20                  25                  30          


Pro Gly Ser Tyr Asp Ser Thr Ser Ser Asp Ser Leu Tyr Pro Arg Gly 
        35                  40                  45              


Ile Gln Phe Lys Arg Pro His Thr Val Ala Pro Trp Pro Pro Ala Tyr 
    50                  55                  60                  


Pro Pro Val Thr Ser Tyr Pro Pro Leu Ser Gln Pro Asp Leu Leu Pro 
65                  70                  75                  80  


Ile Pro Ser Pro Gln Pro Leu Gly Gly Ser His Arg Thr Pro Ser Ser 
                85                  90                  95      


Arg Arg Asp Ser Asp Gly Ala Asn Ser Val Ala Ser Tyr Glu Asn Glu 
            100                 105                 110         


Glu Pro Ala Cys Glu Asp Ala Asp Glu Asp Glu Asp Asp Tyr His Asn 
        115                 120                 125             


Pro Gly Tyr Leu Val Val Leu Pro Asp Ser Thr Pro Ala Thr Ser Thr 
    130                 135                 140                 


Ala Ala Pro Ser Ala Pro Ala Leu Ser Thr Pro Gly Ile Arg Asp Ser 
145                 150                 155                 160 


Ala Phe Ser Met Glu Ser Ile Asp Asp Tyr Val Asn Val Pro Glu Ser 
                165                 170                 175     


Gly Glu Ser Ala Glu Ala Ser Leu Asp Gly Ser Arg Glu Tyr Val Asn 
            180                 185                 190         


Val Ser Gln Glu Leu His Pro Gly Ala Ala Lys Thr Glu Pro Ala Ala 
        195                 200                 205             


Leu Ser Ser Gln Glu Ala Glu Glu Val Glu Glu Glu Gly Ala Pro Asp 
    210                 215                 220                 


Tyr Glu Asn Leu Gln Glu Leu Asn 
225                 230         


<210>  7716
<211>  232
<212>  PRT
<213>  Homo Sapiens

<400>  7716

Met Glu Glu Ala Ile Leu Val Pro Cys Val Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Ile Leu Ala Met Leu Met Ala Leu Cys Val His Cys His Arg Leu 
            20                  25                  30          


Pro Gly Ser Tyr Asp Ser Thr Ser Ser Asp Ser Leu Tyr Pro Arg Gly 
        35                  40                  45              


Ile Gln Phe Lys Arg Pro His Thr Val Ala Pro Trp Pro Pro Ala Tyr 
    50                  55                  60                  


Pro Pro Val Thr Ser Tyr Pro Pro Leu Ser Gln Pro Asp Leu Leu Pro 
65                  70                  75                  80  


Ile Pro Ser Pro Gln Pro Leu Gly Gly Ser His Arg Thr Pro Ser Ser 
                85                  90                  95      


Arg Arg Asp Ser Asp Gly Ala Asn Ser Val Ala Ser Tyr Glu Asn Glu 
            100                 105                 110         


Glu Pro Ala Cys Glu Asp Ala Asp Glu Asp Glu Asp Asp Tyr His Asn 
        115                 120                 125             


Pro Gly Tyr Leu Val Val Leu Pro Asp Ser Thr Pro Ala Thr Ser Thr 
    130                 135                 140                 


Ala Ala Pro Ser Ala Pro Ala Leu Ser Thr Pro Gly Ile Arg Asp Ser 
145                 150                 155                 160 


Ala Phe Ser Met Glu Ser Ile Asp Asp Tyr Val Asn Val Pro Glu Ser 
                165                 170                 175     


Gly Glu Ser Ala Glu Ala Ser Leu Asp Gly Ser Arg Glu Tyr Val Asn 
            180                 185                 190         


Val Ser Gln Glu Leu His Pro Gly Ala Ala Lys Thr Glu Pro Ala Ala 
        195                 200                 205             


Leu Ser Ser Gln Glu Ala Glu Glu Val Glu Glu Glu Gly Ala Pro Asp 
    210                 215                 220                 


Tyr Glu Asn Leu Gln Glu Leu Asn 
225                 230         


<210>  7717
<211>  261
<212>  PRT
<213>  Homo Sapiens

<400>  7717

Met Glu Glu Ala Ile Leu Val Pro Cys Val Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Ile Leu Ala Met Leu Met Ala Leu Cys Val His Cys His Arg Leu 
            20                  25                  30          


Pro Gly Ser Tyr Asp Ser Thr Ser Ser Asp Ser Leu Tyr Pro Arg Gly 
        35                  40                  45              


Ile Gln Phe Lys Arg Pro His Thr Val Ala Pro Trp Pro Pro Ala Tyr 
    50                  55                  60                  


Pro Pro Val Thr Ser Tyr Pro Pro Leu Ser Gln Pro Asp Leu Leu Pro 
65                  70                  75                  80  


Ile Pro Ser Pro Gln Pro Leu Gly Gly Ser His Arg Thr Pro Ser Ser 
                85                  90                  95      


Arg Arg Asp Ser Asp Gly Ala Asn Ser Val Ala Ser Tyr Glu Asn Glu 
            100                 105                 110         


Gly Ala Ser Gly Ile Arg Gly Ala Gln Ala Gly Trp Gly Val Trp Gly 
        115                 120                 125             


Pro Ser Trp Thr Arg Leu Thr Pro Val Ser Leu Pro Pro Glu Pro Ala 
    130                 135                 140                 


Cys Glu Asp Ala Asp Glu Asp Glu Asp Asp Tyr His Asn Pro Gly Tyr 
145                 150                 155                 160 


Leu Val Val Leu Pro Asp Ser Thr Pro Ala Thr Ser Thr Ala Ala Pro 
                165                 170                 175     


Ser Ala Pro Ala Leu Ser Thr Pro Gly Ile Arg Asp Ser Ala Phe Ser 
            180                 185                 190         


Met Glu Ser Ile Asp Asp Tyr Val Asn Val Pro Glu Ser Gly Glu Ser 
        195                 200                 205             


Ala Glu Ala Ser Leu Asp Gly Ser Arg Glu Tyr Val Asn Val Ser Gln 
    210                 215                 220                 


Glu Leu His Pro Gly Ala Ala Lys Thr Glu Pro Ala Ala Leu Ser Ser 
225                 230                 235                 240 


Gln Glu Ala Glu Glu Val Glu Glu Glu Gly Ala Pro Asp Tyr Glu Asn 
                245                 250                 255     


Leu Gln Glu Leu Asn 
            260     


<210>  7718
<211>  100
<212>  PRT
<213>  Homo Sapiens

<400>  7718

Met Ser Ser Gly Thr Glu Leu Leu Trp Pro Gly Ala Ala Leu Leu Val 
1               5                   10                  15      


Leu Leu Gly Val Ala Ala Ser Leu Cys Val Arg Cys Ser Arg Pro Gly 
            20                  25                  30          


Ala Lys Arg Arg Glu Asp Gln Gln Ser Phe Thr Gly Ser Arg Thr Tyr 
        35                  40                  45              


Ser Leu Val Gly Gln Ala Trp Pro Gly Pro Leu Ala Asp Met Ala Pro 
    50                  55                  60                  


Thr Arg Lys Asp Lys Leu Leu Gln Phe Tyr Pro Ser Leu Glu Asp Pro 
65                  70                  75                  80  


Ala Ser Ser Arg Tyr Gln Asn Phe Ser Lys Gly Ser Arg His Gly Ser 
                85                  90                  95      


Glu Glu Ala Tyr 
            100 


<210>  7719
<211>  58
<212>  PRT
<213>  Homo Sapiens

<400>  7719

Met Ser Ser Gly Thr Glu Leu Leu Trp Pro Gly Ala Ala Leu Leu Val 
1               5                   10                  15      


Leu Leu Gly Val Ala Ala Ser Leu Cys Val Arg Cys Ser Arg Pro Gly 
            20                  25                  30          


Ala Lys Arg Ser Glu Lys Ile Tyr Gln Gln Arg Ser Leu Arg Glu Asp 
        35                  40                  45              


Gln Gln Ser Phe Thr Gly Ser Arg Thr Tyr 
    50                  55              


<210>  7720
<211>  64
<212>  PRT
<213>  Homo Sapiens

<400>  7720

Met Ser Ser Gly Thr Glu Leu Leu Trp Pro Gly Ala Ala Leu Leu Val 
1               5                   10                  15      


Leu Leu Gly Val Ala Ala Ser Leu Cys Val Arg Cys Ser Arg Pro Gly 
            20                  25                  30          


Ala Lys Arg Ser Glu Lys Ile Tyr Gln Gln Arg Ser Leu Arg Glu Asp 
        35                  40                  45              


Gln Gln Ser Phe Thr Gly Ser Arg Thr Tyr Ser Leu Val Gly Gln Ala 
    50                  55                  60                  


<210>  7721
<211>  100
<212>  PRT
<213>  Homo Sapiens

<400>  7721

Met Ser Ser Gly Thr Glu Leu Leu Trp Pro Gly Ala Ala Leu Leu Val 
1               5                   10                  15      


Leu Leu Gly Val Ala Ala Ser Leu Cys Val Arg Cys Ser Arg Pro Gly 
            20                  25                  30          


Ala Lys Arg Ser Glu Lys Ile Tyr Gln Gln Arg Ser Leu Arg Glu Asp 
        35                  40                  45              


Gln Gln Ser Phe Thr Gly Ser Arg Thr Tyr Ser Leu Val Gly Gln Ala 
    50                  55                  60                  


Trp Pro Gly Pro Leu Ala Asp Met Ala Pro Thr Arg Lys Asp Lys Leu 
65                  70                  75                  80  


Leu Gln Phe Tyr Pro Ser Leu Glu Asp Pro Ala Ser Ser Arg Tyr Gln 
                85                  90                  95      


Asn Phe Ser Lys 
            100 


<210>  7722
<211>  111
<212>  PRT
<213>  Homo Sapiens

<400>  7722

Met Ser Ser Gly Thr Glu Leu Leu Trp Pro Gly Ala Ala Leu Leu Val 
1               5                   10                  15      


Leu Leu Gly Val Ala Ala Ser Leu Cys Val Arg Cys Ser Arg Pro Gly 
            20                  25                  30          


Ala Lys Arg Ser Glu Lys Ile Tyr Gln Gln Arg Ser Leu Arg Glu Asp 
        35                  40                  45              


Gln Gln Ser Phe Thr Gly Ser Arg Thr Tyr Ser Leu Val Gly Gln Ala 
    50                  55                  60                  


Trp Pro Gly Pro Leu Ala Asp Met Ala Pro Thr Arg Lys Asp Lys Leu 
65                  70                  75                  80  


Leu Gln Phe Tyr Pro Ser Leu Glu Asp Pro Ala Ser Ser Arg Tyr Gln 
                85                  90                  95      


Asn Phe Ser Lys Gly Ser Arg His Gly Ser Glu Glu Ala Tyr Ile 
            100                 105                 110     


<210>  7723
<211>  243
<212>  PRT
<213>  Homo Sapiens

<400>  7723

Met Ser Ser Gly Thr Glu Leu Leu Trp Pro Gly Ala Ala Leu Leu Val 
1               5                   10                  15      


Leu Leu Gly Val Ala Ala Ser Leu Cys Val Arg Cys Ser Arg Pro Gly 
            20                  25                  30          


Ala Lys Arg Ser Glu Lys Ile Tyr Gln Gln Arg Ser Leu Arg Glu Asp 
        35                  40                  45              


Gln Gln Ser Phe Thr Gly Ser Arg Thr Tyr Ser Leu Val Gly Gln Ala 
    50                  55                  60                  


Trp Pro Gly Pro Leu Ala Asp Met Ala Pro Thr Arg Lys Asp Lys Leu 
65                  70                  75                  80  


Leu Gln Phe Tyr Pro Ser Leu Glu Asp Pro Ala Ser Ser Arg Tyr Gln 
                85                  90                  95      


Asn Phe Ser Lys Gly Ser Arg His Gly Ser Glu Glu Ala Tyr Ile Asp 
            100                 105                 110         


Pro Ile Ala Met Glu Tyr Tyr Asn Trp Gly Arg Phe Ser Lys Pro Pro 
        115                 120                 125             


Glu Asp Asp Asp Ala Asn Ser Tyr Glu Asn Val Leu Ile Cys Lys Gln 
    130                 135                 140                 


Lys Thr Thr Glu Thr Gly Ala Gln Gln Glu Gly Ile Gly Gly Leu Cys 
145                 150                 155                 160 


Arg Gly Asp Leu Ser Leu Ser Leu Ala Leu Lys Thr Gly Pro Thr Ser 
                165                 170                 175     


Gly Leu Cys Pro Ser Ala Ser Pro Glu Glu Asp Glu Glu Ser Glu Asp 
            180                 185                 190         


Tyr Gln Asn Ser Ala Ser Ile His Gln Trp Arg Glu Ser Arg Lys Val 
        195                 200                 205             


Met Gly Gln Leu Gln Arg Glu Ala Ser Pro Gly Pro Val Gly Ser Pro 
    210                 215                 220                 


Asp Glu Glu Asp Gly Glu Pro Asp Tyr Val Asn Gly Glu Val Ala Ala 
225                 230                 235                 240 


Thr Glu Ala 
            


<210>  7724
<211>  243
<212>  PRT
<213>  Homo Sapiens

<400>  7724

Met Ser Ser Gly Thr Glu Leu Leu Trp Pro Gly Ala Ala Leu Leu Val 
1               5                   10                  15      


Leu Leu Gly Val Ala Ala Ser Leu Cys Val Arg Cys Ser Arg Pro Gly 
            20                  25                  30          


Ala Lys Arg Ser Glu Lys Ile Tyr Gln Gln Arg Ser Leu Arg Glu Asp 
        35                  40                  45              


Gln Gln Ser Phe Thr Gly Ser Arg Thr Tyr Ser Leu Val Gly Gln Ala 
    50                  55                  60                  


Trp Pro Gly Pro Leu Ala Asp Met Ala Pro Thr Arg Lys Asp Lys Leu 
65                  70                  75                  80  


Leu Gln Phe Tyr Pro Ser Leu Glu Asp Pro Ala Ser Ser Arg Tyr Gln 
                85                  90                  95      


Asn Phe Ser Lys Gly Ser Arg His Gly Ser Glu Glu Ala Tyr Ile Asp 
            100                 105                 110         


Pro Ile Ala Met Glu Tyr Tyr Asn Trp Gly Arg Phe Ser Lys Pro Pro 
        115                 120                 125             


Glu Asp Asp Asp Ala Asn Ser Tyr Glu Asn Val Leu Ile Cys Lys Gln 
    130                 135                 140                 


Lys Thr Thr Glu Thr Gly Ala Gln Gln Glu Gly Ile Gly Gly Leu Cys 
145                 150                 155                 160 


Arg Gly Asp Leu Ser Leu Ser Leu Ala Leu Lys Thr Gly Pro Thr Ser 
                165                 170                 175     


Gly Leu Cys Pro Ser Ala Ser Pro Glu Glu Asp Glu Glu Ser Glu Asp 
            180                 185                 190         


Tyr Gln Asn Ser Ala Ser Ile His Gln Trp Arg Glu Ser Arg Lys Val 
        195                 200                 205             


Met Gly Gln Leu Gln Arg Glu Ala Ser Pro Gly Pro Val Gly Ser Pro 
    210                 215                 220                 


Asp Glu Glu Asp Gly Glu Pro Asp Tyr Val Asn Gly Glu Val Ala Ala 
225                 230                 235                 240 


Thr Glu Ala 
            


<210>  7725
<211>  243
<212>  PRT
<213>  Homo Sapiens

<400>  7725

Met Ser Ser Gly Thr Glu Leu Leu Trp Pro Gly Ala Ala Leu Leu Val 
1               5                   10                  15      


Leu Leu Gly Val Ala Ala Ser Leu Cys Val Arg Cys Ser Arg Pro Gly 
            20                  25                  30          


Ala Lys Arg Ser Glu Lys Ile Tyr Gln Gln Arg Ser Leu Arg Glu Asp 
        35                  40                  45              


Gln Gln Ser Phe Thr Gly Ser Arg Thr Tyr Ser Leu Val Gly Gln Ala 
    50                  55                  60                  


Trp Pro Gly Pro Leu Ala Asp Met Ala Pro Thr Arg Lys Asp Lys Leu 
65                  70                  75                  80  


Leu Gln Phe Tyr Pro Ser Leu Glu Asp Pro Ala Ser Ser Arg Tyr Gln 
                85                  90                  95      


Asn Phe Ser Lys Gly Ser Arg His Gly Ser Glu Glu Ala Tyr Ile Asp 
            100                 105                 110         


Pro Ile Ala Met Glu Tyr Tyr Asn Trp Gly Arg Phe Ser Lys Pro Pro 
        115                 120                 125             


Glu Asp Asp Asp Ala Asn Ser Tyr Glu Asn Val Leu Ile Cys Lys Gln 
    130                 135                 140                 


Lys Thr Thr Glu Thr Gly Ala Gln Gln Glu Gly Ile Gly Gly Leu Cys 
145                 150                 155                 160 


Arg Gly Asp Leu Ser Leu Ser Leu Ala Leu Lys Thr Gly Pro Thr Ser 
                165                 170                 175     


Gly Leu Cys Pro Ser Ala Ser Pro Glu Glu Asp Glu Glu Ser Glu Asp 
            180                 185                 190         


Tyr Gln Asn Ser Ala Ser Ile His Gln Trp Arg Glu Ser Arg Lys Val 
        195                 200                 205             


Met Gly Gln Leu Gln Arg Glu Ala Ser Pro Gly Pro Val Gly Ser Pro 
    210                 215                 220                 


Asp Glu Glu Asp Gly Glu Pro Asp Tyr Val Asn Gly Glu Val Ala Ala 
225                 230                 235                 240 


Thr Glu Ala 
            


<210>  7726
<211>  243
<212>  PRT
<213>  Homo Sapiens

<400>  7726

Met Ser Ser Gly Thr Glu Leu Leu Trp Pro Gly Ala Ala Leu Leu Val 
1               5                   10                  15      


Leu Leu Gly Val Ala Ala Ser Leu Cys Val Arg Cys Ser Arg Pro Gly 
            20                  25                  30          


Ala Lys Arg Ser Glu Lys Ile Tyr Gln Gln Arg Ser Leu Arg Glu Asp 
        35                  40                  45              


Gln Gln Ser Phe Thr Gly Ser Arg Thr Tyr Ser Leu Val Gly Gln Ala 
    50                  55                  60                  


Trp Pro Gly Pro Leu Ala Asp Met Ala Pro Thr Arg Lys Asp Lys Leu 
65                  70                  75                  80  


Leu Gln Phe Tyr Pro Ser Leu Glu Asp Pro Ala Ser Ser Arg Tyr Gln 
                85                  90                  95      


Asn Phe Ser Lys Gly Ser Arg His Gly Ser Glu Glu Ala Tyr Ile Asp 
            100                 105                 110         


Pro Ile Ala Met Glu Tyr Tyr Asn Trp Gly Arg Phe Ser Lys Pro Pro 
        115                 120                 125             


Glu Asp Asp Asp Ala Asn Ser Tyr Glu Asn Val Leu Ile Cys Lys Gln 
    130                 135                 140                 


Lys Thr Thr Glu Thr Gly Ala Gln Gln Glu Gly Ile Gly Gly Leu Cys 
145                 150                 155                 160 


Arg Gly Asp Leu Ser Leu Ser Leu Ala Leu Lys Thr Gly Pro Thr Ser 
                165                 170                 175     


Gly Leu Cys Pro Ser Ala Ser Pro Glu Glu Asp Glu Glu Ser Glu Asp 
            180                 185                 190         


Tyr Gln Asn Ser Ala Ser Ile His Gln Trp Arg Glu Ser Arg Lys Val 
        195                 200                 205             


Met Gly Gln Leu Gln Arg Glu Ala Ser Pro Gly Pro Val Gly Ser Pro 
    210                 215                 220                 


Asp Glu Glu Asp Gly Glu Pro Asp Tyr Val Asn Gly Glu Val Ala Ala 
225                 230                 235                 240 


Thr Glu Ala 
            


<210>  7727
<211>  481
<212>  PRT
<213>  Homo Sapiens

<400>  7727

Met Gly Ala Leu Ala Arg Ala Leu Pro Ser Ile Leu Leu Ala Leu Leu 
1               5                   10                  15      


Leu Thr Ser Thr Pro Glu Ala Leu Gly Ala Asn Pro Gly Leu Val Ala 
            20                  25                  30          


Arg Ile Thr Asp Lys Gly Leu Gln Tyr Ala Ala Gln Glu Gly Leu Leu 
        35                  40                  45              


Ala Leu Gln Ser Glu Leu Leu Arg Ile Thr Leu Pro Asp Phe Thr Gly 
    50                  55                  60                  


Asp Leu Arg Ile Pro His Val Gly Arg Gly Arg Tyr Glu Phe His Ser 
65                  70                  75                  80  


Leu Asn Ile His Ser Cys Glu Leu Leu His Ser Ala Leu Arg Pro Val 
                85                  90                  95      


Pro Gly Gln Gly Leu Ser Leu Ser Ile Ser Asp Ser Ser Ile Arg Val 
            100                 105                 110         


Gln Gly Arg Trp Lys Val Arg Lys Ser Phe Phe Lys Leu Gln Gly Ser 
        115                 120                 125             


Phe Asp Val Ser Val Lys Gly Ile Ser Ile Ser Val Asn Leu Leu Leu 
    130                 135                 140                 


Gly Ser Glu Ser Ser Gly Arg Pro Thr Val Thr Ala Ser Ser Cys Ser 
145                 150                 155                 160 


Ser Asp Ile Ala Asp Val Glu Val Asp Met Ser Gly Asp Leu Gly Trp 
                165                 170                 175     


Leu Leu Asn Leu Phe His Asn Gln Ile Glu Ser Lys Phe Gln Lys Val 
            180                 185                 190         


Leu Glu Ser Arg Ile Cys Glu Met Ile Gln Lys Ser Val Ser Ser Asp 
        195                 200                 205             


Leu Gln Pro Tyr Leu Gln Thr Leu Pro Val Thr Thr Glu Ile Asp Ser 
    210                 215                 220                 


Phe Ala Asp Ile Asp Tyr Ser Leu Val Glu Ala Pro Arg Ala Thr Ala 
225                 230                 235                 240 


Gln Met Leu Glu Val Met Phe Lys Gly Glu Ile Phe His Arg Asn His 
                245                 250                 255     


Arg Ser Pro Val Thr Leu Leu Ala Ala Val Met Ser Leu Pro Glu Glu 
            260                 265                 270         


His Asn Lys Met Val Tyr Phe Ala Ile Ser Asp Tyr Val Phe Asn Thr 
        275                 280                 285             


Ala Ser Leu Val Tyr His Glu Glu Gly Tyr Leu Asn Phe Ser Ile Thr 
    290                 295                 300                 


Asp Asp Met Ile Pro Pro Asp Ser Asn Ile Arg Leu Thr Thr Lys Ser 
305                 310                 315                 320 


Phe Arg Pro Phe Val Pro Arg Leu Ala Arg Leu Tyr Pro Asn Met Asn 
                325                 330                 335     


Leu Glu Leu Gln Gly Ser Val Pro Ser Ala Pro Leu Leu Asn Phe Ser 
            340                 345                 350         


Pro Gly Asn Leu Ser Val Asp Pro Tyr Met Glu Ile Asp Ala Phe Val 
        355                 360                 365             


Leu Leu Pro Ser Ser Ser Lys Glu Pro Val Phe Arg Leu Ser Val Ala 
    370                 375                 380                 


Thr Asn Val Ser Ala Thr Leu Thr Phe Asn Thr Ser Lys Ile Thr Gly 
385                 390                 395                 400 


Phe Leu Lys Pro Gly Lys Val Lys Val Glu Leu Lys Glu Ser Lys Val 
                405                 410                 415     


Gly Leu Phe Asn Ala Glu Leu Leu Glu Ala Leu Leu Asn Tyr Tyr Ile 
            420                 425                 430         


Leu Asn Thr Phe Tyr Pro Lys Phe Asn Asp Lys Leu Ala Glu Gly Phe 
        435                 440                 445             


Pro Leu Pro Leu Leu Lys Arg Val Gln Leu Tyr Asp Leu Gly Leu Gln 
    450                 455                 460                 


Ile His Lys Asp Phe Leu Phe Leu Gly Ala Asn Val Gln Tyr Met Arg 
465                 470                 475                 480 


Val 
    


<210>  7728
<211>  255
<212>  PRT
<213>  Homo Sapiens

<400>  7728

Met Cys Tyr Arg Lys Thr Glu Asp Phe Phe Thr Ile Trp Leu Asp Leu 
1               5                   10                  15      


Asn Met Phe Leu Pro Leu Gly Val Asp Cys Trp Ile Asp Asn Thr Arg 
            20                  25                  30          


Val Val Tyr Asn Arg Ser Ser Gly Leu Val Ser Asn Ala Pro Gly Val 
        35                  40                  45              


Gln Ile Arg Val Pro Gly Phe Gly Lys Thr Tyr Ser Val Glu Tyr Leu 
    50                  55                  60                  


Asp Ser Ser Lys Leu Ala Gly Tyr Leu His Thr Leu Val Gln Asn Leu 
65                  70                  75                  80  


Val Asn Asn Gly Tyr Val Arg Asp Glu Thr Val Arg Ala Ala Pro Tyr 
                85                  90                  95      


Asp Trp Arg Leu Glu Pro Gly Gln Gln Glu Glu Tyr Tyr Arg Lys Leu 
            100                 105                 110         


Ala Gly Leu Val Glu Glu Met His Ala Ala Tyr Gly Lys Pro Val Phe 
        115                 120                 125             


Leu Ile Gly His Ser Leu Gly Cys Leu His Leu Leu Tyr Phe Leu Leu 
    130                 135                 140                 


Arg Gln Pro Gln Ala Trp Lys Asp Arg Phe Ile Asp Gly Phe Ile Ser 
145                 150                 155                 160 


Leu Gly Ala Pro Trp Gly Gly Ser Ile Lys Pro Met Leu Val Leu Ala 
                165                 170                 175     


Ser Gly Asp Asn Gln Gly Ile Pro Ile Met Ser Ser Ile Lys Leu Lys 
            180                 185                 190         


Glu Glu Gln Arg Ile Thr Thr Thr Ser Pro Trp Met Phe Pro Ser Arg 
        195                 200                 205             


Met Ala Trp Pro Glu Asp His Val Phe Ile Ser Thr Pro Ser Phe Asn 
    210                 215                 220                 


Tyr Thr Gly Arg Asp Phe Gln Arg Phe Phe Ala Asp Leu His Phe Glu 
225                 230                 235                 240 


Glu Gly Trp Tyr Met Trp Leu Gln Ser Arg Asp Leu Leu Ala Gly 
                245                 250                 255 


<210>  7729
<211>  93
<212>  PRT
<213>  Homo Sapiens

<400>  7729

Met Gly Pro Pro Gly Ser Pro Trp Gln Trp Val Thr Leu Leu Leu Gly 
1               5                   10                  15      


Leu Leu Leu Pro Pro Ala Ala Pro Phe Trp Leu Leu Asn Val Leu Phe 
            20                  25                  30          


Pro Pro His Thr Thr Pro Lys Ala Glu Leu Ser Asn His Thr Arg Pro 
        35                  40                  45              


Val Ile Leu Ala Arg Ser Gln Ala Gly Gln Thr Arg Cys Gly Glu Leu 
    50                  55                  60                  


Asp Val Leu Pro Gln Asp Arg Gly Leu Leu His His Leu Ala Gly Ser 
65                  70                  75                  80  


Gln His Val Pro Thr Pro Trp Gly Arg Leu Leu Asp Arg 
                85                  90              


<210>  7730
<211>  440
<212>  PRT
<213>  Homo Sapiens

<400>  7730

Met Gly Pro Pro Gly Ser Pro Trp Gln Trp Val Thr Leu Leu Leu Gly 
1               5                   10                  15      


Leu Leu Leu Pro Pro Ala Ala Pro Phe Trp Leu Leu Asn Val Leu Phe 
            20                  25                  30          


Pro Pro His Thr Thr Pro Lys Ala Glu Leu Ser Asn His Thr Arg Pro 
        35                  40                  45              


Val Ile Leu Val Pro Gly Cys Leu Gly Asn Gln Leu Glu Ala Lys Leu 
    50                  55                  60                  


Asp Lys Pro Asp Val Val Asn Trp Met Cys Tyr Arg Lys Thr Glu Asp 
65                  70                  75                  80  


Phe Phe Thr Ile Trp Leu Asp Leu Asn Met Phe Leu Pro Leu Gly Val 
                85                  90                  95      


Asp Cys Trp Ile Asp Asn Thr Arg Val Val Tyr Asn Arg Ser Ser Gly 
            100                 105                 110         


Leu Val Ser Asn Ala Pro Gly Val Gln Ile Arg Val Pro Gly Phe Gly 
        115                 120                 125             


Lys Thr Tyr Ser Val Glu Tyr Leu Asp Ser Ser Lys Leu Ala Gly Tyr 
    130                 135                 140                 


Leu His Thr Leu Val Gln Asn Leu Val Asn Asn Gly Tyr Val Arg Asp 
145                 150                 155                 160 


Glu Thr Val Arg Ala Ala Pro Tyr Asp Trp Arg Leu Glu Pro Gly Gln 
                165                 170                 175     


Gln Glu Glu Tyr Tyr Arg Lys Leu Ala Gly Leu Val Glu Glu Met His 
            180                 185                 190         


Ala Ala Tyr Gly Lys Pro Val Phe Leu Ile Gly His Ser Leu Gly Cys 
        195                 200                 205             


Leu His Leu Leu Tyr Phe Leu Leu Arg Gln Pro Gln Ala Trp Lys Asp 
    210                 215                 220                 


Arg Phe Ile Asp Gly Phe Ile Ser Leu Gly Ala Pro Trp Gly Gly Ser 
225                 230                 235                 240 


Ile Lys Pro Met Leu Val Leu Ala Ser Gly Asp Asn Gln Gly Ile Pro 
                245                 250                 255     


Ile Met Ser Ser Ile Lys Leu Lys Glu Glu Gln Arg Ile Thr Thr Thr 
            260                 265                 270         


Ser Pro Trp Met Phe Pro Ser Arg Met Ala Trp Pro Glu Asp His Val 
        275                 280                 285             


Phe Ile Ser Thr Pro Ser Phe Asn Tyr Thr Gly Arg Asp Phe Gln Arg 
    290                 295                 300                 


Phe Phe Ala Asp Leu His Phe Glu Glu Gly Trp Tyr Met Trp Leu Gln 
305                 310                 315                 320 


Ser Arg Asp Leu Leu Ala Gly Leu Pro Ala Pro Gly Val Glu Val Tyr 
                325                 330                 335     


Cys Leu Tyr Gly Val Gly Leu Pro Thr Pro Arg Thr Tyr Ile Tyr Asp 
            340                 345                 350         


His Gly Phe Pro Tyr Thr Asp Pro Val Gly Val Leu Tyr Glu Asp Gly 
        355                 360                 365             


Asp Asp Thr Val Ala Thr Arg Ser Thr Glu Leu Cys Gly Leu Trp Gln 
    370                 375                 380                 


Gly Arg Gln Pro Gln Pro Val His Leu Leu Pro Leu His Gly Ile Gln 
385                 390                 395                 400 


His Leu Asn Met Val Phe Ser Asn Leu Thr Leu Glu His Ile Asn Ala 
                405                 410                 415     


Ile Leu Leu Gly Ala Tyr Arg Gln Gly Pro Pro Ala Ser Pro Thr Ala 
            420                 425                 430         


Ser Pro Glu Pro Pro Pro Pro Glu 
        435                 440 


<210>  7731
<211>  61
<212>  PRT
<213>  Homo Sapiens

<400>  7731

Ser Pro Arg Pro Gly Arg Thr Ala Leu Leu Met Ala Ser Ser Leu Leu 
1               5                   10                  15      


Gly Leu Pro Gly Val Ala Pro Ser Ser Pro Cys Trp Ser Trp Pro Gln 
            20                  25                  30          


Glu Cys Leu Cys Pro Gly Met Cys Phe Thr Glu Asp Gly Ser Ala Arg 
        35                  40                  45              


Ala Arg Ala Arg Pro Pro Glu Ala Pro Pro Ala Leu Pro 
    50                  55                  60      


<210>  7732
<211>  138
<212>  PRT
<213>  Homo Sapiens

<400>  7732

Val Gln Ile Arg Val Pro Gly Phe Gly Lys Thr Tyr Ser Val Glu Tyr 
1               5                   10                  15      


Leu Asp Ser Ser Lys Leu Ala Gly Tyr Leu His Thr Leu Val Gln Asn 
            20                  25                  30          


Leu Val Asn Asn Gly Tyr Val Arg Asp Glu Thr Val Arg Ala Ala Pro 
        35                  40                  45              


Tyr Asp Trp Arg Leu Glu Pro Gly Gln Gln Glu Glu Tyr Tyr Arg Lys 
    50                  55                  60                  


Leu Ala Gly Leu Val Glu Glu Met His Ala Ala Tyr Gly Lys Pro Val 
65                  70                  75                  80  


Phe Leu Ile Gly His Ser Leu Gly Cys Leu His Leu Leu Tyr Phe Leu 
                85                  90                  95      


Leu Arg Gln Pro Gln Ala Trp Lys Asp Arg Phe Ile Asp Gly Phe Ile 
            100                 105                 110         


Ser Leu Gly Ala Pro Trp Gly Gly Ser Ile Lys Pro Met Leu Val Leu 
        115                 120                 125             


Ala Ser Glu Thr Gly Ser His Cys Ile Ala 
    130                 135             


<210>  7733
<211>  80
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7733

Xaa Glu Tyr Tyr Arg Lys Leu Ala Gly Leu Val Glu Glu Met His Ala 
1               5                   10                  15      


Ala Tyr Gly Lys Pro Val Phe Leu Ile Gly His Ser Leu Gly Cys Leu 
            20                  25                  30          


His Leu Leu Tyr Phe Leu Leu Arg Gln Pro Gln Ala Trp Lys Asp Arg 
        35                  40                  45              


Phe Ile Asp Gly Phe Ile Ser Leu Gly Ala Pro Trp Gly Gly Ser Ile 
    50                  55                  60                  


Lys Pro Met Leu Val Leu Ala Ser Gly Ser Gly Thr Arg Ala Gln His 
65                  70                  75                  80  


<210>  7734
<211>  107
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7734

Xaa Leu Pro Leu Gly Val Asp Cys Trp Ile Asp Asn Thr Arg Val Val 
1               5                   10                  15      


Tyr Asn Arg Ser Ser Gly Leu Val Ser Asn Ala Pro Gly Val Gln Ile 
            20                  25                  30          


Arg Val Pro Gly Phe Gly Lys Thr Tyr Ser Val Glu Tyr Leu Asp Ser 
        35                  40                  45              


Ser Lys Leu Ala Gly Pro Pro Ala Thr Ala Cys Ala Pro Ala Ala Pro 
    50                  55                  60                  


Ala Arg Asp Thr Ala Ser Gln His Gly Leu Gln Gln Pro Asp Pro Gly 
65                  70                  75                  80  


Ala His Gln Cys His Pro Ala Gly Cys Leu Pro Pro Gly Ser Pro Cys 
                85                  90                  95      


Ile Pro Asp Cys Gln Pro Arg Ala Pro Ala Ser 
            100                 105         


<210>  7735
<211>  176
<212>  PRT
<213>  Homo Sapiens

<400>  7735

Met Lys Pro Leu Leu Leu Ala Val Ser Leu Gly Leu Ile Ala Ala Leu 
1               5                   10                  15      


Gln Ala His His Leu Leu Ala Ser Asp Glu Glu Ile Gln Asp Val Ser 
            20                  25                  30          


Gly Thr Trp Tyr Leu Lys Ala Met Thr Val Asp Arg Glu Phe Pro Glu 
        35                  40                  45              


Met Asn Leu Glu Ser Val Thr Pro Met Thr Leu Thr Thr Leu Glu Gly 
    50                  55                  60                  


Gly Asn Leu Glu Ala Lys Val Thr Met Leu Ile Ser Gly Arg Cys Gln 
65                  70                  75                  80  


Glu Val Lys Ala Val Leu Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr 
                85                  90                  95      


Ala Asp Gly Gly Lys His Val Ala Tyr Ile Ile Arg Ser His Val Lys 
            100                 105                 110         


Asp His Tyr Ile Phe Tyr Cys Glu Gly Glu Leu His Gly Lys Pro Val 
        115                 120                 125             


Arg Gly Val Lys Leu Val Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala 
    130                 135                 140                 


Leu Glu Asp Phe Glu Lys Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu 
145                 150                 155                 160 


Ser Ile Leu Ile Pro Arg Gln Ser Glu Thr Cys Ser Pro Gly Ser Asp 
                165                 170                 175     


<210>  7736
<211>  176
<212>  PRT
<213>  Homo Sapiens

<400>  7736

Met Lys Pro Leu Leu Leu Ala Val Ser Leu Gly Leu Ile Ala Ala Leu 
1               5                   10                  15      


Gln Ala His His Leu Leu Ala Ser Asp Glu Glu Ile Gln Asp Val Ser 
            20                  25                  30          


Gly Thr Trp Tyr Leu Lys Ala Met Thr Val Asp Arg Glu Phe Pro Glu 
        35                  40                  45              


Met Asn Leu Glu Ser Val Thr Pro Met Thr Leu Thr Thr Leu Glu Gly 
    50                  55                  60                  


Gly Asn Leu Glu Ala Lys Val Thr Met Leu Ile Ser Gly Arg Cys Gln 
65                  70                  75                  80  


Glu Val Lys Ala Val Leu Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr 
                85                  90                  95      


Ala Asp Gly Gly Lys His Val Ala Tyr Ile Ile Arg Ser His Val Lys 
            100                 105                 110         


Asp His Tyr Ile Phe Tyr Cys Glu Gly Glu Leu His Gly Lys Pro Val 
        115                 120                 125             


Arg Gly Val Lys Leu Val Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala 
    130                 135                 140                 


Leu Glu Asp Phe Glu Lys Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu 
145                 150                 155                 160 


Ser Ile Leu Ile Pro Arg Gln Ser Glu Thr Cys Ser Pro Gly Ser Asp 
                165                 170                 175     


<210>  7737
<211>  86
<212>  PRT
<213>  Homo Sapiens

<400>  7737

Met Arg Gln Gly Leu Leu Val Leu Ala Leu Val Leu Val Leu Val Leu 
1               5                   10                  15      


Val Leu Ala Ala Gly Ser Gln Val Gln Glu Trp Tyr Pro Arg Glu Ser 
            20                  25                  30          


His Ala Leu Asn Trp Asn Lys Phe Ser Gly Phe Trp Tyr Ile Leu Ala 
        35                  40                  45              


Thr Ala Thr Asp Ala Gln Gly Phe Leu Pro Ala Arg Asp Lys Arg Lys 
    50                  55                  60                  


Leu Gly Ala Ser Val Val Lys Val Asn Lys Val Gly Gln Leu Arg Val 
65                  70                  75                  80  


Leu Leu Ala Phe Arg Arg 
                85      


<210>  7738
<211>  187
<212>  PRT
<213>  Homo Sapiens

<400>  7738

Met Arg Gln Gly Leu Leu Val Leu Ala Leu Val Leu Val Leu Val Leu 
1               5                   10                  15      


Val Leu Ala Ala Gly Ser Gln Val Gln Glu Trp Tyr Pro Arg Glu Ser 
            20                  25                  30          


His Ala Leu Asn Trp Asn Lys Phe Ser Gly Phe Trp Tyr Ile Leu Ala 
        35                  40                  45              


Thr Ala Thr Asp Ala Gln Gly Phe Leu Pro Ala Arg Asp Lys Arg Lys 
    50                  55                  60                  


Leu Gly Ala Ser Val Val Lys Val Asn Lys Val Gly Gln Leu Arg Val 
65                  70                  75                  80  


Leu Leu Ala Phe Arg Arg Gly Gln Gly Cys Gly Arg Ala Gln Pro Arg 
                85                  90                  95      


His Pro Gly Thr Ser Gly His Leu Trp Ala Ser Leu Ser Val Lys Gly 
            100                 105                 110         


Val Lys Ala Phe His Val Leu Ser Thr Asp Tyr Ser Tyr Gly Leu Val 
        115                 120                 125             


Tyr Leu Arg Leu Gly Arg Ala Thr Gln Asn Tyr Lys Asn Leu Leu Leu 
    130                 135                 140                 


Phe His Arg Gln Asn Val Ser Ser Phe Gln Ser Leu Lys Glu Phe Met 
145                 150                 155                 160 


Asp Ala Cys Asp Ile Leu Gly Leu Ser Lys Ala Ala Val Ile Leu Pro 
                165                 170                 175     


Lys Asp Ala Ser Arg Thr His Thr Ile Leu Pro 
            180                 185         


<210>  7739
<211>  164
<212>  PRT
<213>  Homo Sapiens

<400>  7739

Met Arg Gln Gly Leu Leu Val Leu Ala Leu Val Leu Val Leu Val Leu 
1               5                   10                  15      


Val Leu Ala Ala Gly Ser Gln Val Gln Glu Trp Tyr Pro Arg Glu Ser 
            20                  25                  30          


His Ala Leu Asn Trp Asn Lys Phe Ser Gly Phe Trp Tyr Ile Leu Ala 
        35                  40                  45              


Thr Ala Thr Asp Ala Gln Gly Phe Leu Pro Ala Arg Asp Lys Arg Lys 
    50                  55                  60                  


Leu Gly Ala Ser Val Val Lys Val Asn Lys Val Gly Gln Leu Arg Val 
65                  70                  75                  80  


Leu Leu Ala Phe Arg Arg Leu Lys Gly Cys Gln Ser Gln Glu Val Ile 
                85                  90                  95      


Leu Arg Lys Asp Gly Lys Lys Pro Val Phe Gly Asn Ala Cys Ala Tyr 
            100                 105                 110         


Ala Ala Gly Pro Arg Glu Gly Gln Glu Gly Asp Arg Gln Asn Val Ser 
        115                 120                 125             


Ser Phe Gln Ser Leu Lys Glu Phe Met Asp Ala Cys Asp Ile Leu Gly 
    130                 135                 140                 


Leu Ser Lys Ala Ala Val Ile Leu Pro Lys Asp Ala Ser Arg Thr His 
145                 150                 155                 160 


Thr Ile Leu Pro 
                


<210>  7740
<211>  200
<212>  PRT
<213>  Homo Sapiens

<400>  7740

Met Arg Gln Gly Leu Leu Val Leu Ala Leu Val Leu Val Leu Val Leu 
1               5                   10                  15      


Val Leu Ala Ala Gly Ser Gln Val Gln Glu Trp Tyr Pro Arg Glu Ser 
            20                  25                  30          


His Ala Leu Asn Trp Asn Lys Phe Ser Gly Phe Trp Tyr Ile Leu Ala 
        35                  40                  45              


Thr Ala Thr Asp Ala Gln Gly Phe Leu Pro Ala Arg Asp Lys Arg Lys 
    50                  55                  60                  


Leu Gly Ala Ser Val Val Lys Val Asn Lys Val Gly Gln Leu Arg Val 
65                  70                  75                  80  


Leu Leu Ala Phe Arg Arg Leu Lys Gly Cys Gln Ser Gln Glu Val Ile 
                85                  90                  95      


Leu Arg Lys Asp Gly Lys Lys Pro Val Phe Gly Asn Ala Cys Ala Tyr 
            100                 105                 110         


Ala Ala Gly Pro Arg Glu Gly Gln Glu Gly Val Lys Gly Val Lys Ala 
        115                 120                 125             


Phe His Val Leu Ser Thr Asp Tyr Ser Tyr Gly Leu Val Tyr Leu Arg 
    130                 135                 140                 


Leu Gly Arg Ala Thr Gln Asn Tyr Lys Asn Leu Leu Leu Phe His Arg 
145                 150                 155                 160 


Gln Asn Val Ser Ser Phe Gln Ser Leu Lys Glu Phe Met Asp Ala Cys 
                165                 170                 175     


Asp Ile Leu Gly Leu Ser Lys Ala Ala Val Ile Leu Pro Lys Asp Ala 
            180                 185                 190         


Ser Arg Thr His Thr Ile Leu Pro 
        195                 200 


<210>  7741
<211>  75
<212>  PRT
<213>  Homo Sapiens

<400>  7741

Met Arg Gln Gly Leu Leu Val Leu Ala Leu Val Leu Val Leu Val Leu 
1               5                   10                  15      


Val Leu Ala Ala Gly Ser Gln Val Gln Glu Trp Tyr Pro Arg Glu Ser 
            20                  25                  30          


His Ala Leu Asn Trp Asn Lys Gly Gln Glu Glu Ala Gly Gly Val Arg 
        35                  40                  45              


Gly Lys Gly Glu Gln Ser Gly Pro Ala Pro Arg Ala Pro Arg Leu Gln 
    50                  55                  60                  


Thr Ile Gly Arg Met Phe Arg Ala Ser Arg Val 
65                  70                  75  


<210>  7742
<211>  37
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7742

Xaa Thr Asp Ala Gln Gly Phe Leu Pro Ala Arg Asp Lys Arg Lys Leu 
1               5                   10                  15      


Gly Ala Ser Val Val Lys Val Asn Lys Val Gly Gln Leu Arg Val Leu 
            20                  25                  30          


Leu Ala Phe Arg Arg 
        35          


<210>  7743
<211>  102
<212>  PRT
<213>  Homo Sapiens

<400>  7743

Ala Leu Leu Asn Ala Phe Thr Ala Thr Phe Glu Leu Ser Asp Asp Gly 
1               5                   10                  15      


Arg Phe Glu Val Trp Asn Ala Met Thr Arg Gly Gln His Cys Asp Thr 
            20                  25                  30          


Trp Ser Tyr Val Leu Ile Pro Ala Ala Gln Pro Gly Gln Phe Thr Val 
        35                  40                  45              


Asp His Gly Val Gly Arg Ser Trp Leu Leu Pro Pro Gly Thr Leu Asp 
    50                  55                  60                  


Gln Phe Ile Cys Leu Gly Arg Ala Gln Gly Leu Ser Asp Asp Asn Ile 
65                  70                  75                  80  


Val Phe Pro Asp Val Thr Gly Gly Ala Leu Asp Leu Ser Ser Leu Pro 
                85                  90                  95      


Trp Val Ala Ala Pro Ala 
            100         


<210>  7744
<211>  192
<212>  PRT
<213>  Homo Sapiens

<400>  7744

Met Arg Leu Leu Cys Gly Leu Trp Leu Trp Leu Ser Leu Leu Lys Val 
1               5                   10                  15      


Leu Gln Ala Gln Thr Pro Thr Pro Leu Pro Leu Pro Pro Pro Met Gln 
            20                  25                  30          


Ser Phe Gln Gly Asn Gln Phe Gln Gly Glu Trp Phe Val Leu Gly Leu 
        35                  40                  45              


Ala Gly Asn Ser Phe Arg Pro Glu His Arg Ala Leu Leu Asn Ala Phe 
    50                  55                  60                  


Thr Ala Thr Phe Glu Leu Ser Asp Asp Gly Arg Phe Glu Val Trp Asn 
65                  70                  75                  80  


Ala Met Thr Arg Gly Gln His Cys Asp Thr Trp Ser Tyr Val Leu Ile 
                85                  90                  95      


Pro Ala Ala Gln Pro Gly Gln Phe Thr Val Asp His Gly Val Glu Pro 
            100                 105                 110         


Gly Ala Asp Arg Glu Glu Thr Arg Val Val Asp Ser Asp Tyr Thr Gln 
        115                 120                 125             


Phe Ala Leu Met Leu Ser Arg Arg His Thr Ser Arg Leu Ala Val Leu 
    130                 135                 140                 


Arg Ile Ser Leu Leu Gly Arg Ser Trp Leu Leu Pro Pro Gly Thr Leu 
145                 150                 155                 160 


Asp Gln Phe Ile Cys Leu Gly Arg Ala Gln Gly Leu Ser Asp Asp Asn 
                165                 170                 175     


Ile Val Phe Pro Asp Val Thr Gly Trp Ser Pro Gln Ala Ser Val Cys 
            180                 185                 190         


<210>  7745
<211>  90
<212>  PRT
<213>  Homo Sapiens

<400>  7745

Thr Phe Glu Leu Ser Asp Asp Gly Arg Phe Glu Val Trp Asn Ala Met 
1               5                   10                  15      


Thr Arg Gly Gln His Cys Asp Thr Trp Ser Tyr Val Leu Ile Pro Ala 
            20                  25                  30          


Ala Gln Pro Gly Gln Phe Thr Val Asp His Gly Val Asp Thr Arg Ala 
        35                  40                  45              


Gly Trp Pro Ser Ser Gly Ser Ala Cys Trp Ala Gly Ala Gly Cys Cys 
    50                  55                  60                  


Leu Pro Gly Arg Trp Thr Ser Ser Ser Ala Trp Ala Glu Leu Arg Ala 
65                  70                  75                  80  


Ser Arg Met Thr Thr Ser Ser Ser Gln Met 
                85                  90  


<210>  7746
<211>  184
<212>  PRT
<213>  Homo Sapiens

<400>  7746

Met Met Ser Phe Leu Leu Gly Ala Ile Leu Thr Leu Leu Trp Ala Pro 
1               5                   10                  15      


Thr Ala Gln Ala Glu Val Leu Leu Gln Pro Asp Phe Asn Ala Glu Lys 
            20                  25                  30          


Phe Ser Gly Leu Trp Tyr Val Val Ser Met Ala Ser Asp Cys Arg Val 
        35                  40                  45              


Phe Leu Gly Lys Lys Asp His Leu Ser Met Ser Thr Arg Ala Ile Arg 
    50                  55                  60                  


Pro Thr Glu Glu Gly Gly Leu His Val His Met Glu Phe Pro Gly Ala 
65                  70                  75                  80  


Asp Gly Cys Asn Gln Val Asp Ala Glu Tyr Leu Lys Val Gly Ser Glu 
                85                  90                  95      


Gly His Phe Arg Val Pro Ala Leu Gly Tyr Leu Asp Val Arg Ile Val 
            100                 105                 110         


Asp Thr Asp Tyr Ser Ser Phe Ala Val Leu Tyr Ile Tyr Lys Glu Leu 
        115                 120                 125             


Glu Gly Ala Leu Ser Thr Met Val Gln Leu Tyr Ser Arg Thr Gln Asp 
    130                 135                 140                 


Val Ser Pro Gln Ala Leu Lys Ser Phe Gln Asp Phe Tyr Pro Thr Leu 
145                 150                 155                 160 


Gly Leu Pro Lys Asp Met Met Val Met Leu Pro Gln Ser Asp Ala Cys 
                165                 170                 175     


Asn Pro Glu Ser Lys Glu Ala Pro 
            180                 


<210>  7747
<211>  200
<212>  PRT
<213>  Homo Sapiens

<400>  7747

Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
            20                  25                  30          


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln 
        35                  40                  45              


Gly Lys Trp Tyr Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu 
    50                  55                  60                  


Asp Lys Asp Pro Gln Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu 
65                  70                  75                  80  


Asp Lys Ser Tyr Asn Val Thr Ser Val Leu Phe Arg Glu Lys Ala Gln 
                85                  90                  95      


Lys Cys Asp Tyr Trp Ile Arg Thr Phe Val Pro Gly Cys Gln Pro Gly 
            100                 105                 110         


Glu Phe Thr Leu Gly Asn Ile Lys Ser Tyr Pro Gly Leu Thr Ser Tyr 
        115                 120                 125             


Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe 
    130                 135                 140                 


Phe Lys Lys Val Ser Gln Asn Arg Glu Tyr Phe Lys Ile Thr Leu Tyr 
145                 150                 155                 160 


Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg 
                165                 170                 175     


Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val 
            180                 185                 190         


Pro Ile Asp Gln Cys Ile Asp Gly 
        195                 200 


<210>  7748
<211>  198
<212>  PRT
<213>  Homo Sapiens

<400>  7748

Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
            20                  25                  30          


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln 
        35                  40                  45              


Gly Lys Trp Tyr Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu 
    50                  55                  60                  


Asp Lys Asp Pro Gln Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu 
65                  70                  75                  80  


Asp Lys Ser Tyr Asn Val Thr Ser Val Leu Phe Arg Lys Lys Lys Cys 
                85                  90                  95      


Asp Tyr Trp Ile Arg Thr Phe Val Pro Gly Cys Gln Pro Gly Glu Phe 
            100                 105                 110         


Thr Leu Gly Asn Ile Lys Ser Tyr Pro Gly Leu Thr Ser Tyr Leu Val 
        115                 120                 125             


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys 
    130                 135                 140                 


Lys Val Ser Gln Asn Arg Glu Tyr Phe Lys Ile Thr Leu Tyr Gly Arg 
145                 150                 155                 160 


Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
                165                 170                 175     


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
            180                 185                 190         


Asp Gln Cys Ile Asp Gly 
        195             


<210>  7749
<211>  198
<212>  PRT
<213>  Homo Sapiens

<400>  7749

Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
            20                  25                  30          


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln 
        35                  40                  45              


Gly Lys Trp Tyr Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu 
    50                  55                  60                  


Asp Lys Asp Pro Gln Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu 
65                  70                  75                  80  


Asp Lys Ser Tyr Asn Val Thr Ser Val Leu Phe Arg Lys Lys Lys Cys 
                85                  90                  95      


Asp Tyr Trp Ile Arg Thr Phe Val Pro Gly Cys Gln Pro Gly Glu Phe 
            100                 105                 110         


Thr Leu Gly Asn Ile Lys Ser Tyr Pro Gly Leu Thr Ser Tyr Leu Val 
        115                 120                 125             


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys 
    130                 135                 140                 


Lys Val Ser Gln Asn Arg Glu Tyr Phe Lys Ile Thr Leu Tyr Gly Arg 
145                 150                 155                 160 


Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
                165                 170                 175     


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
            180                 185                 190         


Asp Gln Cys Ile Asp Gly 
        195             


<210>  7750
<211>  78
<212>  PRT
<213>  Homo Sapiens

<400>  7750

Met Asp Leu Ile Lys Arg Asn Ser Gly Trp Val Phe Glu Asn Pro Ser 
1               5                   10                  15      


Ile Gly Val Leu Glu Leu Trp Val Leu Ala Thr Asn Phe Arg Asp Tyr 
            20                  25                  30          


Ala Ile Ile Phe Thr Gln Leu Glu Phe Gly Asp Glu Pro Phe Asn Thr 
        35                  40                  45              


Val Glu Leu Tyr Ser Leu Thr Glu Thr Ala Ser Gln Glu Ala Met Gly 
    50                  55                  60                  


Leu Phe Thr Lys Trp Ser Arg Ser Leu Gly Phe Leu Ser Gln 
65                  70                  75              


<210>  7751
<211>  163
<212>  PRT
<213>  Homo Sapiens

<400>  7751

Met Gly Gly Leu Leu Leu Ala Ala Phe Leu Ala Leu Val Ser Val Pro 
1               5                   10                  15      


Arg Ala Gln Ala Val Trp Leu Gly Arg Leu Asp Pro Glu Gln Leu Leu 
            20                  25                  30          


Gly Pro Trp Tyr Val Leu Ala Val Ala Ser Arg Glu Lys Gly Phe Ala 
        35                  40                  45              


Met Glu Lys Asp Met Lys Asn Val Val Gly Val Val Val Thr Leu Thr 
    50                  55                  60                  


Pro Glu Asn Asn Leu Arg Thr Leu Ser Ser Gln His Gly Leu Gly Gly 
65                  70                  75                  80  


Cys Asp Gln Ser Val Met Asp Leu Ile Lys Arg Asn Ser Gly Trp Val 
                85                  90                  95      


Phe Glu Asn Pro Ser Ile Gly Val Leu Glu Leu Trp Val Leu Ala Thr 
            100                 105                 110         


Asn Phe Arg Asp Tyr Ala Ile Ile Phe Thr Gln Leu Glu Phe Gly Asp 
        115                 120                 125             


Glu Pro Phe Asn Thr Val Glu Leu Tyr Ser Leu Thr Glu Thr Ala Ser 
    130                 135                 140                 


Gln Glu Ala Met Gly Leu Phe Thr Lys Trp Ser Arg Ser Leu Gly Phe 
145                 150                 155                 160 


Leu Ser Gln 
            


<210>  7752
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  7752

Met Glu Glu Leu Asp Arg Gln Lys Ile Gly Gly Phe Trp Arg Glu Val 
1               5                   10                  15      


Gly Val Ala Ser Asp Gln Ser Leu Val Leu Thr Ala Pro Lys Arg Val 
            20                  25                  30          


Glu Gly Leu Phe Leu Thr Leu Ser Gly Ser Asn Leu Thr Val Lys Val 
        35                  40                  45              


Ala Tyr Asn Ser Ser Gly Ser Cys Glu Ile Glu Lys Ile Val Gly Ser 
    50                  55                  60                  


Glu Ile Asp Ser Thr Gly Lys Phe Ala Phe Pro Gly His Arg Glu Ile 
65                  70                  75                  80  


His Val Leu Asp Thr Asp Tyr Glu Gly Tyr Ala Ile Leu Arg Val Ser 
                85                  90                  95      


Leu Met Trp Arg Gly Arg Asn Phe Arg Val Leu Lys Tyr Phe Thr Arg 
            100                 105                 110         


Ser Leu Glu Asp Lys Asp Arg Leu Gly Phe Trp Lys Phe Arg Glu Leu 
        115                 120                 125             


Thr Ala Asp Thr Gly Leu Tyr Leu Ala Ala Arg Pro Gly Arg Cys Ala 
    130                 135                 140                 


Glu Leu Leu Lys Glu Glu Leu Ile 
145                 150         


<210>  7753
<211>  175
<212>  PRT
<213>  Homo Sapiens

<400>  7753

Met Pro Gly Ala Ala Glu Ala Leu Pro Thr Val Thr Val Thr Leu Val 
1               5                   10                  15      


Ala Gly Ala Val Pro Pro Ala Ser Gly Ala Leu Thr Ala His Cys Ile 
            20                  25                  30          


Gly Gly Phe Trp Arg Glu Val Gly Val Ala Ser Asp Gln Ser Leu Val 
        35                  40                  45              


Leu Thr Ala Pro Lys Arg Val Glu Gly Leu Phe Leu Thr Leu Ser Gly 
    50                  55                  60                  


Ser Asn Leu Thr Val Lys Val Ala Tyr Asn Ser Ser Gly Ser Cys Glu 
65                  70                  75                  80  


Ile Glu Lys Ile Val Gly Ser Glu Ile Asp Ser Thr Gly Lys Phe Ala 
                85                  90                  95      


Phe Pro Gly His Arg Glu Ile His Val Leu Asp Thr Asp Tyr Glu Gly 
            100                 105                 110         


Tyr Ala Ile Leu Arg Val Ser Leu Met Trp Arg Gly Arg Asn Phe Arg 
        115                 120                 125             


Val Leu Lys Tyr Phe Thr Arg Ser Leu Glu Asp Lys Asp Arg Leu Gly 
    130                 135                 140                 


Phe Trp Lys Phe Arg Glu Leu Thr Ala Asp Thr Gly Leu Tyr Leu Ala 
145                 150                 155                 160 


Ala Arg Pro Gly Arg Cys Ala Glu Leu Leu Lys Glu Glu Leu Ile 
                165                 170                 175 


<210>  7754
<211>  176
<212>  PRT
<213>  Homo Sapiens

<400>  7754

Met Ala Leu Leu Leu Leu Ser Leu Gly Leu Ser Leu Ile Ala Ala Gln 
1               5                   10                  15      


Glu Phe Asp Pro His Thr Val Met Gln Arg Asn Tyr Asn Val Ala Arg 
            20                  25                  30          


Val Ser Gly Val Trp Tyr Ser Ile Phe Met Ala Ser Asp Asp Leu Asn 
        35                  40                  45              


Arg Ile Lys Glu Asn Gly Asp Leu Arg Val Phe Val Arg Asn Ile Glu 
    50                  55                  60                  


His Leu Lys Asn Gly Ser Leu Ile Phe Asp Phe Glu Tyr Met Val Gln 
65                  70                  75                  80  


Gly Glu Cys Val Ala Val Val Val Val Cys Glu Lys Thr Glu Lys Asn 
                85                  90                  95      


Gly Glu Tyr Ser Ile Asn Tyr Glu Gly Gln Asn Thr Val Ala Val Ser 
            100                 105                 110         


Glu Thr Asp Tyr Arg Leu Phe Ile Thr Phe His Leu Gln Asn Phe Arg 
        115                 120                 125             


Asn Gly Thr Glu Thr His Thr Leu Ala Leu Tyr Glu Thr Cys Glu Lys 
    130                 135                 140                 


Tyr Gly Leu Gly Ser Gln Asn Ile Ile Asp Leu Thr Asn Lys Asp Pro 
145                 150                 155                 160 


Cys Tyr Ser Lys His Tyr Arg Ser Pro Pro Arg Pro Pro Met Arg Glu 
                165                 170                 175     


<210>  7755
<211>  176
<212>  PRT
<213>  Homo Sapiens

<400>  7755

Met Ala Leu Leu Leu Leu Ser Leu Gly Leu Ser Leu Ile Ala Ala Gln 
1               5                   10                  15      


Glu Phe Asp Pro His Thr Val Met Gln Arg Asn Tyr Asn Val Ala Arg 
            20                  25                  30          


Val Ser Gly Val Trp Tyr Ser Ile Phe Met Ala Ser Asp Asp Leu Asn 
        35                  40                  45              


Arg Ile Lys Glu Asn Gly Asp Leu Arg Val Phe Val Arg Asn Ile Glu 
    50                  55                  60                  


His Leu Lys Asn Gly Ser Leu Ile Phe Asp Phe Glu Tyr Met Val Gln 
65                  70                  75                  80  


Gly Glu Cys Val Ala Val Val Val Val Cys Glu Lys Thr Glu Lys Asn 
                85                  90                  95      


Gly Glu Tyr Ser Ile Asn Tyr Glu Gly Gln Asn Thr Val Ala Val Ser 
            100                 105                 110         


Glu Thr Asp Tyr Arg Leu Phe Ile Thr Phe His Leu Gln Asn Phe Arg 
        115                 120                 125             


Asn Gly Thr Glu Thr His Thr Leu Ala Leu Tyr Glu Thr Cys Glu Lys 
    130                 135                 140                 


Tyr Gly Leu Gly Ser Gln Asn Ile Ile Asp Leu Thr Asn Lys Asp Pro 
145                 150                 155                 160 


Cys Tyr Ser Lys His Tyr Arg Ser Pro Pro Arg Pro Pro Met Arg Trp 
                165                 170                 175     


<210>  7756
<211>  518
<212>  PRT
<213>  Homo Sapiens

<400>  7756

Met Asp Glu Lys Cys Ser Phe Cys Asn Leu Gln Arg Glu Ala Val Ser 
1               5                   10                  15      


Asp Cys Ile Pro Ser Leu Asp Ser Ser Gln Ser Thr Pro Thr Glu Glu 
            20                  25                  30          


Leu Ser Ser Gln Gly Gln Ser Asn Thr Asp Lys Ile Glu Cys Gln Ala 
        35                  40                  45              


Glu Asn Tyr Leu Asn Ala Leu Phe Arg Lys Lys Asp Leu Pro Gln Asn 
    50                  55                  60                  


Cys Asp Pro Asn Ile Pro Leu Val Ala Gln Glu Leu Met Lys Lys Met 
65                  70                  75                  80  


Ile Arg Gln Phe Ala Ile Glu Tyr Ile Ser Lys Ser Gly Lys Thr Gln 
                85                  90                  95      


Glu Asn Arg Asn Gly Ser Ile Gly Pro Ser Ile Val Cys Lys Ser Ile 
            100                 105                 110         


Gln Met Asn Gln Ala Glu Asn Ser Leu Gln Glu Glu Gln Glu Gly Pro 
        115                 120                 125             


Leu Asp Leu Thr Val Asn Arg Met Gln Glu Gln Asn Thr Gln Gln Gly 
    130                 135                 140                 


Asp Gly Val Leu Asp Leu Ser Thr Lys Lys Thr Ser Ile Lys Ser Glu 
145                 150                 155                 160 


Glu Ser Ser Ile Cys Asp Pro Ser Ser Glu Asn Ser Val Ala Gly Arg 
                165                 170                 175     


Leu His Arg Asn Arg Glu Asp Tyr Val Glu Arg Ser Ala Glu Phe Ala 
            180                 185                 190         


Asp Gly Leu Leu Ser Lys Ala Leu Lys Asp Ile Gln Ser Gly Ala Leu 
        195                 200                 205             


Asp Ile Asn Lys Ala Gly Ile Leu Tyr Gly Ile Pro Gln Lys Thr Leu 
    210                 215                 220                 


Leu Leu His Leu Glu Ala Leu Pro Ala Gly Lys Pro Ala Ser Phe Lys 
225                 230                 235                 240 


Asn Lys Thr Arg Asp Phe His Asp Ser Tyr Ser Tyr Lys Asp Ser Lys 
                245                 250                 255     


Glu Thr Cys Ala Val Leu Gln Lys Val Ala Leu Trp Ala Arg Ala Gln 
            260                 265                 270         


Ala Glu Arg Thr Glu Lys Ser Lys Leu Asn Leu Leu Glu Thr Ser Glu 
        275                 280                 285             


Ile Lys Phe Pro Thr Ala Ser Thr Tyr Leu His Gln Leu Thr Leu Gln 
    290                 295                 300                 


Lys Met Val Thr Gln Phe Lys Glu Lys Asn Glu Ser Leu Gln Tyr Glu 
305                 310                 315                 320 


Thr Ser Asn Pro Thr Val Gln Leu Lys Ile Pro Gln Leu Arg Val Ser 
                325                 330                 335     


Ser Val Ser Lys Ser Gln Pro Asp Gly Ser Gly Leu Leu Asp Val Met 
            340                 345                 350         


Tyr Gln Val Ser Lys Thr Ser Ser Val Leu Glu Gly Ser Ala Leu Gln 
        355                 360                 365             


Lys Leu Lys Asn Ile Leu Pro Lys Gln Asn Lys Ile Glu Cys Ser Gly 
    370                 375                 380                 


Pro Val Thr His Ser Ser Val Asp Ser Tyr Phe Leu His Gly Asp Leu 
385                 390                 395                 400 


Ser Pro Leu Cys Leu Asn Ser Lys Asn Gly Thr Val Asp Gly Thr Ser 
                405                 410                 415     


Glu Asn Thr Glu Asp Gly Leu Asp Arg Lys Asp Ser Lys Gln Pro Arg 
            420                 425                 430         


Lys Lys Arg Gly Arg Tyr Arg Gln Tyr Asp His Glu Ile Met Glu Glu 
        435                 440                 445             


Ala Ile Ala Met Val Met Ser Gly Lys Met Ser Val Ser Lys Ala Gln 
    450                 455                 460                 


Gly Ile Tyr Gly Val Pro His Ser Thr Leu Glu Tyr Lys Val Lys Glu 
465                 470                 475                 480 


Arg Ser Gly Thr Leu Lys Thr Pro Pro Lys Lys Lys Leu Arg Leu Pro 
                485                 490                 495     


Asp Thr Gly Leu Tyr Asn Met Thr Asp Ser Gly Thr Gly Ser Cys Lys 
            500                 505                 510         


Asn Ser Ser Lys Pro Val 
        515             


<210>  7757
<211>  318
<212>  PRT
<213>  Homo Sapiens

<400>  7757

Met Asp Lys Gly Arg Glu Arg Met Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Ala Ala Ala Gln Cys Arg Ser Pro Arg Cys Ala Ala Glu 
            20                  25                  30          


Arg Arg Gly Phe Arg Arg Glu Leu Asp Ser Trp Arg His Arg Leu Met 
        35                  40                  45              


His Cys Val Gly Phe Glu Ser Ile Leu Glu Gly Leu Tyr Gly Pro Arg 
    50                  55                  60                  


Leu Arg Arg Asp Leu Ser Leu Phe Glu Asp Cys Glu Pro Glu Glu Leu 
65                  70                  75                  80  


Thr Asp Trp Ser Met Asp Glu Lys Cys Ser Phe Cys Asn Leu Gln Arg 
                85                  90                  95      


Glu Ala Val Ser Asp Cys Ile Pro Ser Leu Asp Ser Ser Gln Ser Thr 
            100                 105                 110         


Pro Thr Glu Glu Leu Ser Ser Gln Gly Gln Ser Asn Thr Asp Lys Ile 
        115                 120                 125             


Glu Cys Gln Ala Glu Asn Tyr Leu Asn Ala Leu Phe Arg Lys Lys Asp 
    130                 135                 140                 


Leu Pro Gln Asn Cys Asp Pro Asn Ile Pro Leu Val Ala Gln Glu Leu 
145                 150                 155                 160 


Met Lys Lys Met Ile Arg Gln Phe Ala Ile Glu Tyr Ile Ser Lys Ser 
                165                 170                 175     


Gly Lys Thr Gln Glu Asn Arg Asn Gly Ser Ile Gly Pro Ser Ile Val 
            180                 185                 190         


Cys Lys Ser Ile Gln Met Asn Gln Ala Glu Asn Ser Leu Gln Glu Glu 
        195                 200                 205             


Gln Glu Gly Pro Leu Asp Leu Thr Val Asn Arg Met Gln Glu Gln Asn 
    210                 215                 220                 


Thr Gln Gln Gly Asp Gly Val Leu Asp Leu Ser Thr Lys Lys Thr Ser 
225                 230                 235                 240 


Ile Lys Ser Glu Glu Ser Ser Ile Cys Asp Pro Ser Ser Glu Asn Ser 
                245                 250                 255     


Val Ala Gly Met Leu Gln Val Lys Thr Asp Glu Lys Leu Asn Val Ser 
            260                 265                 270         


Asp Glu Asn Thr Ala Ser Cys Pro Leu Ser Pro Ile Lys Met Cys Leu 
        275                 280                 285             


Asn Arg Pro Ile Glu Trp Asn Leu Asn Leu Thr Thr Ala Ser Leu Thr 
    290                 295                 300                 


Ser Cys Thr Val His Asn Gln Asn Leu Lys Ser Glu Glu Lys 
305                 310                 315             


<210>  7758
<211>  602
<212>  PRT
<213>  Homo Sapiens

<400>  7758

Met Asp Lys Gly Arg Glu Arg Met Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Ala Ala Ala Gln Cys Arg Ser Pro Arg Cys Ala Ala Glu 
            20                  25                  30          


Arg Arg Gly Phe Arg Arg Glu Leu Asp Ser Trp Arg His Arg Leu Met 
        35                  40                  45              


His Cys Val Gly Phe Glu Ser Ile Leu Glu Gly Leu Tyr Gly Pro Arg 
    50                  55                  60                  


Leu Arg Arg Asp Leu Ser Leu Phe Glu Asp Cys Glu Pro Glu Glu Leu 
65                  70                  75                  80  


Thr Asp Trp Ser Met Asp Glu Lys Cys Ser Phe Cys Asn Leu Gln Arg 
                85                  90                  95      


Glu Ala Val Ser Asp Cys Ile Pro Ser Leu Asp Ser Ser Gln Ser Thr 
            100                 105                 110         


Pro Thr Glu Glu Leu Ser Ser Gln Gly Gln Ser Asn Thr Asp Lys Ile 
        115                 120                 125             


Glu Cys Gln Ala Glu Asn Tyr Leu Asn Ala Leu Phe Arg Lys Lys Asp 
    130                 135                 140                 


Leu Pro Gln Asn Cys Asp Pro Asn Ile Pro Leu Val Ala Gln Glu Leu 
145                 150                 155                 160 


Met Lys Lys Met Ile Arg Gln Phe Ala Ile Glu Tyr Ile Ser Lys Ser 
                165                 170                 175     


Gly Lys Thr Gln Glu Asn Arg Asn Gly Ser Ile Gly Pro Ser Ile Val 
            180                 185                 190         


Cys Lys Ser Ile Gln Met Asn Gln Ala Glu Asn Ser Leu Gln Glu Glu 
        195                 200                 205             


Gln Glu Gly Pro Leu Asp Leu Thr Val Asn Arg Met Gln Glu Gln Asn 
    210                 215                 220                 


Thr Gln Gln Gly Asp Gly Val Leu Asp Leu Ser Thr Lys Lys Thr Ser 
225                 230                 235                 240 


Ile Lys Ser Glu Glu Ser Ser Ile Cys Asp Pro Ser Ser Glu Asn Ser 
                245                 250                 255     


Val Ala Gly Arg Leu His Arg Asn Arg Glu Asp Tyr Val Glu Arg Ser 
            260                 265                 270         


Ala Glu Phe Ala Asp Gly Leu Leu Ser Lys Ala Leu Lys Asp Ile Gln 
        275                 280                 285             


Ser Gly Ala Leu Asp Ile Asn Lys Ala Gly Ile Leu Tyr Gly Ile Pro 
    290                 295                 300                 


Gln Lys Thr Leu Leu Leu His Leu Glu Ala Leu Pro Ala Gly Lys Pro 
305                 310                 315                 320 


Ala Ser Phe Lys Asn Lys Thr Arg Asp Phe His Asp Ser Tyr Ser Tyr 
                325                 330                 335     


Lys Asp Ser Lys Glu Thr Cys Ala Val Leu Gln Lys Val Ala Leu Trp 
            340                 345                 350         


Ala Arg Ala Gln Ala Glu Arg Thr Glu Lys Ser Lys Leu Asn Leu Leu 
        355                 360                 365             


Glu Thr Ser Glu Ile Lys Phe Pro Thr Ala Ser Thr Tyr Leu His Gln 
    370                 375                 380                 


Leu Thr Leu Gln Lys Met Val Thr Gln Phe Lys Glu Lys Asn Glu Ser 
385                 390                 395                 400 


Leu Gln Tyr Glu Thr Ser Asn Pro Thr Val Gln Leu Lys Ile Pro Gln 
                405                 410                 415     


Leu Arg Val Ser Ser Val Ser Lys Ser Gln Pro Asp Gly Ser Gly Leu 
            420                 425                 430         


Leu Asp Val Met Tyr Gln Val Ser Lys Thr Ser Ser Val Leu Glu Gly 
        435                 440                 445             


Ser Ala Leu Gln Lys Leu Lys Asn Ile Leu Pro Lys Gln Asn Lys Ile 
    450                 455                 460                 


Glu Cys Ser Gly Pro Val Thr His Ser Ser Val Asp Ser Tyr Phe Leu 
465                 470                 475                 480 


His Gly Asp Leu Ser Pro Leu Cys Leu Asn Ser Lys Asn Gly Thr Val 
                485                 490                 495     


Asp Gly Thr Ser Glu Asn Thr Glu Asp Gly Leu Asp Arg Lys Asp Ser 
            500                 505                 510         


Lys Gln Pro Arg Lys Lys Arg Gly Arg Tyr Arg Gln Tyr Asp His Glu 
        515                 520                 525             


Ile Met Glu Glu Ala Ile Ala Met Val Met Ser Gly Lys Met Ser Val 
    530                 535                 540                 


Ser Lys Ala Gln Gly Ile Tyr Gly Val Pro His Ser Thr Leu Glu Tyr 
545                 550                 555                 560 


Lys Val Lys Glu Arg Ser Gly Thr Leu Lys Thr Pro Pro Lys Lys Lys 
                565                 570                 575     


Leu Arg Leu Pro Asp Thr Gly Leu Tyr Asn Met Thr Asp Ser Gly Thr 
            580                 585                 590         


Gly Ser Cys Lys Asn Ser Ser Lys Pro Val 
        595                 600         


<210>  7759
<211>  1871
<212>  PRT
<213>  Homo Sapiens

<400>  7759

Met Asp Lys Gly Arg Glu Arg Met Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Ala Ala Ala Gln Cys Arg Ser Pro Arg Cys Ala Ala Glu 
            20                  25                  30          


Arg Arg Gly Phe Arg Arg Glu Leu Asp Ser Trp Arg His Arg Leu Met 
        35                  40                  45              


His Cys Val Gly Phe Glu Ser Ile Leu Glu Gly Leu Tyr Gly Pro Arg 
    50                  55                  60                  


Leu Arg Arg Asp Leu Ser Leu Phe Glu Asp Cys Glu Pro Glu Glu Leu 
65                  70                  75                  80  


Thr Asp Trp Ser Met Asp Glu Lys Cys Ser Phe Cys Asn Leu Gln Arg 
                85                  90                  95      


Glu Ala Val Ser Asp Cys Ile Pro Ser Leu Asp Ser Ser Gln Ser Thr 
            100                 105                 110         


Pro Thr Glu Glu Leu Ser Ser Gln Gly Gln Ser Asn Thr Asp Lys Ile 
        115                 120                 125             


Glu Cys Gln Ala Glu Asn Tyr Leu Asn Ala Leu Phe Arg Lys Lys Asp 
    130                 135                 140                 


Leu Pro Gln Asn Cys Asp Pro Asn Ile Pro Leu Val Ala Gln Glu Leu 
145                 150                 155                 160 


Met Lys Lys Met Ile Arg Gln Phe Ala Ile Glu Tyr Ile Ser Lys Ser 
                165                 170                 175     


Gly Lys Thr Gln Glu Asn Arg Asn Gly Ser Ile Gly Pro Ser Ile Val 
            180                 185                 190         


Cys Lys Ser Ile Gln Met Asn Gln Ala Glu Asn Ser Leu Gln Glu Glu 
        195                 200                 205             


Gln Glu Gly Pro Leu Asp Leu Thr Val Asn Arg Met Gln Glu Gln Asn 
    210                 215                 220                 


Thr Gln Gln Gly Asp Gly Val Leu Asp Leu Ser Thr Lys Lys Thr Ser 
225                 230                 235                 240 


Ile Lys Ser Glu Glu Ser Ser Ile Cys Asp Pro Ser Ser Glu Asn Ser 
                245                 250                 255     


Val Ala Gly Ser Thr Val Asp Ala Lys Ser Glu Glu Ala Thr Lys Met 
            260                 265                 270         


Glu Lys Arg Lys Ser Ala Leu Asn Lys Val Leu Glu Ser Leu Cys Ile 
        275                 280                 285             


His His Gln Gln Gln Val Leu Ala Met Leu Lys Phe Leu Val Gln Glu 
    290                 295                 300                 


Gln Asn Ala Ala Ser Leu Cys Cys Cys Asn Thr Ser Cys Val Val Ser 
305                 310                 315                 320 


Ser Glu Ser Gln Lys Pro Leu Ile Glu Asp Asp Leu Cys Gly Leu Phe 
                325                 330                 335     


Cys Ser Cys Glu Tyr Arg Leu Ala Glu Arg Gly Cys Leu Gln Asn Glu 
            340                 345                 350         


Lys Gln Ser Pro Gly Leu Glu Pro Leu Pro Val Cys Ile Lys Asp Leu 
        355                 360                 365             


His Cys Leu Ser Cys Gln Thr Val Thr Val Glu His Val Lys Pro Val 
    370                 375                 380                 


Val Asn Arg Gly Ile Ala Asp Ser Tyr Asn Ser His Arg Cys Cys Ser 
385                 390                 395                 400 


Gly Leu Leu Pro Asn Ile His Ser Thr Lys Ser Ala Phe Arg Ser Pro 
                405                 410                 415     


Leu Leu Ser Lys Glu Val Cys Asp Leu Ser Val Thr Leu Lys Asp Ala 
            420                 425                 430         


Cys Arg Ser Arg Ser Pro Ser Pro Pro Pro Leu Ser Pro Ile Glu Thr 
        435                 440                 445             


Glu Gly Phe Glu Lys Leu Lys Asp Val Ile Ser Glu Ile Ser Ala Leu 
    450                 455                 460                 


Glu Asn Asn Lys Leu Glu Ala Asn Ile Asn Gln Pro Pro Ser Leu Thr 
465                 470                 475                 480 


Pro Ala Glu Ile Ser Ser Asn Lys Ser Asp His Gln Asp Lys Ile Leu 
                485                 490                 495     


Lys Thr Lys Lys Ser Ser Asn Ser Tyr Ser Leu Leu Ser Asn Asp Ser 
            500                 505                 510         


Asn Asn Ser Thr Thr Asn His Glu Lys Gly Glu Thr Ala Val Ile Phe 
        515                 520                 525             


Gln Asp Leu Met Asp Arg Ile Asn Glu Lys Leu Lys Ser Ile Glu Thr 
    530                 535                 540                 


Thr Asp Met Thr Ser Leu Val Lys Leu Ser Ser Ser Asp Tyr Asn Thr 
545                 550                 555                 560 


Tyr Asn Asp Leu Lys Leu Gly Asp Phe Ile Thr Ser Leu Leu His Asn 
                565                 570                 575     


Ala Lys Ala Ser Asp Tyr Ser Phe Met Glu Leu Leu Ser Gln His Asp 
            580                 585                 590         


Lys Lys Val Glu Asn Lys Ile Ile Gln Thr Arg Phe Arg Lys Arg Gln 
        595                 600                 605             


Glu Thr Leu Phe Ala Met Arg Asn Ser Ser Asp Ser Pro Met Phe Arg 
    610                 615                 620                 


Arg Gln Ser Leu Gln Ile Lys Arg Glu Leu Ala Ser Leu Asp Glu Asn 
625                 630                 635                 640 


Phe Thr Arg Lys Lys Tyr Thr Glu Lys Ser Ser Arg Lys Leu Thr Gln 
                645                 650                 655     


Asn Asn Glu Ile Ser Ser Ser Asp Lys Gly Glu Phe Tyr His Asp Gln 
            660                 665                 670         


Gly Pro Ser Leu Gln Asn Ser Lys Arg Leu Gln Gly Lys Asn His Ala 
        675                 680                 685             


Glu Thr Ser Phe Ser Pro Asn Tyr Ala Leu Gln Ser Leu Gln Leu Pro 
    690                 695                 700                 


Leu His Ser Ser Glu Thr Asn Leu Ser Phe Asn Glu Phe Ser Glu Ser 
705                 710                 715                 720 


Phe Lys Thr Thr Ser Pro Glu Lys Met Ser Ile Arg Lys Pro Gln Glu 
                725                 730                 735     


Lys Ser Ala Asp Gly Lys Gln Phe Leu Gln Asn Asp Arg Lys Asn Pro 
            740                 745                 750         


Lys Leu Gly Asn Thr Gln Thr Leu Leu Arg Asn Asp Val Ser Gly Leu 
        755                 760                 765             


Leu Ser Arg Thr Lys Arg Asn Ile Val Pro Pro Gly Trp Tyr Ser Val 
    770                 775                 780                 


Tyr Val Thr Asn Asn Tyr Val Phe Lys Lys Ser Pro Lys Ala Lys Lys 
785                 790                 795                 800 


Val Ser Glu Ser Thr Thr Lys Asn Asp Pro Val Lys Asn Ile His Ile 
                805                 810                 815     


Glu Ser Ser His Asn Ile Asp Leu Asn Lys Ile Ala Met Asn Ser Asn 
            820                 825                 830         


Leu Gln Val Val Val Lys Arg Leu Glu Asp Thr Ile Ser Ile Ala Lys 
        835                 840                 845             


Lys Ser Trp Asn Asn Gln Pro Leu Ser Glu Gly Tyr Lys Ala Ser Lys 
    850                 855                 860                 


Lys Leu Ile Glu Ile Asp Gly Lys Asp Gln His Ala Asp Arg Asn Met 
865                 870                 875                 880 


Thr Leu Thr Leu Asn Arg Met Thr Cys Lys Glu Gln Ser Leu Ser Lys 
                885                 890                 895     


Ser Val Val Ala Ser Gly Asn Ile Ile Asn Ser His Cys Met Pro Thr 
            900                 905                 910         


Val Asp Leu Asn Asn Lys Arg Leu Glu Asn Leu Lys Lys Ser Ser Ile 
        915                 920                 925             


Leu Asp Met Gly Arg Leu Ile Ser Ser Val Glu Asn Val Pro Ala Lys 
    930                 935                 940                 


Tyr Glu Gly Thr Glu Ser Ser Ser Val Ser Asn Tyr Ser Ser Pro Ile 
945                 950                 955                 960 


Lys Leu Met Phe Leu Ser Glu Val Lys Ser Ser Glu Gly Val Lys Tyr 
                965                 970                 975     


Thr Leu Thr Ser Val Gly Thr Ser His Ser Asn Val Val Leu Pro Ser 
            980                 985                 990         


Glu Lys Pro Thr Thr His His Val  Thr Glu Glu Lys Thr  Glu Thr Asn 
        995                 1000                 1005             


Glu Asp  Ile Ser Asn Ala Asn  Ser Glu Asn Tyr His  Ser Ser His 
    1010                 1015                 1020             


Tyr Asp  Thr Asp Thr Phe Gln  Arg Glu Leu Asn Lys  Phe Ser His 
    1025                 1030                 1035             


Ala Lys  Glu Thr Ala Gly Ser  Ser Thr Met Phe Ile  Gly Asp Ile 
    1040                 1045                 1050             


Asn Ser  Asp Lys Pro Gln Glu  Glu Pro Lys Asp Asn  Ser Ser Ser 
    1055                 1060                 1065             


Ala Thr  Asp Pro Ser Phe Lys  Arg Lys Pro Gly Arg  Pro Lys Lys 
    1070                 1075                 1080             


Ile Gly  Pro Gln Val Val Lys  Gln Ile Lys Arg Pro  Ile Gly Arg 
    1085                 1090                 1095             


Pro Pro  Lys Pro Lys Ile Asp  Gln Thr Asn Ile Thr  Val Cys Gln 
    1100                 1105                 1110             


Asn Glu  Pro Phe Ser Ala Gly  Arg Lys Ser Pro Glu  Cys Leu Ile 
    1115                 1120                 1125             


Ser Glu  Val Lys Glu Gly Ile  Tyr Lys Lys Ser Ile  Thr Val Thr 
    1130                 1135                 1140             


Val Ile  Tyr Gly Arg Ser Arg  Arg Thr Lys Arg His  Val Ser Glu 
    1145                 1150                 1155             


Gly Arg  Val Asn Ile Ser Asn  Leu Met Ser Leu Asn  Asn Asn Ala 
    1160                 1165                 1170             


Gly Asp  Phe Pro Thr Glu Tyr  Asn Ser Pro Arg Asn  Ile Ser Glu 
    1175                 1180                 1185             


Asp Lys  Ile Asp Leu Gly Glu  Arg Ile Ser Ala Val  Ala Ser Leu 
    1190                 1195                 1200             


Thr Thr  Glu Ser Glu Ile Leu  Gly Ser Gly Phe Glu  Tyr Val Arg 
    1205                 1210                 1215             


Pro Ile  Lys Asn Lys Ser Val  Ile Pro Gln Pro Ser  Lys Asn Ile 
    1220                 1225                 1230             


Ile Arg  Pro Asn Gln Lys Pro  Leu Ala Ile Ser Arg  Lys Pro Gly 
    1235                 1240                 1245             


Arg Pro  Ala Lys Val Lys Ile  Ser Gly Ile Ser Val  Thr Ile Asn 
    1250                 1255                 1260             


Arg Thr  Ser Pro Gln Glu Arg  Glu Val Ser Ile Ser  Ser Cys Leu 
    1265                 1270                 1275             


Pro Pro  Leu Glu Gln Asp Asn  Thr Ser Gly Lys Asn  Leu Pro Glu 
    1280                 1285                 1290             


Glu Lys  Tyr Asp Gln Gln Cys  Thr Gln Met Asp Lys  Ile Arg His 
    1295                 1300                 1305             


Thr Glu  Ala Asp Ile Phe Lys  Asn Gly Ser Lys Arg  Met Ile Ala 
    1310                 1315                 1320             


Thr Val  Pro Leu Arg His Ser  Ile Arg Asp Arg Lys  Pro Ser Leu 
    1325                 1330                 1335             


His Phe  Leu His Ser Leu Ala  Ser Ser Ser Ser Leu  Ile Tyr Arg 
    1340                 1345                 1350             


Asn Ala  Leu Leu His Lys Ser  Tyr Lys Leu His Leu  Gln Lys Asn 
    1355                 1360                 1365             


Lys Ser  Gln Lys Glu Lys His  Arg His Ser Lys Met  Lys Ile Ala 
    1370                 1375                 1380             


Tyr Lys  Asp Thr Pro Arg Asn  Arg Leu Ser Arg Asn  Ala Lys Lys 
    1385                 1390                 1395             


Cys Leu  Glu Asp Asn Lys Leu  Val Pro Ile Ser Glu  Val Ser Leu 
    1400                 1405                 1410             


Asp Pro  Ile Ile Ser Ser Asn  Pro Leu Leu Arg Trp  Trp Ala Thr 
    1415                 1420                 1425             


Ser Ala  Ser Asn Asp Ser Leu  Leu Glu Glu Leu Asn  Asn Arg Phe 
    1430                 1435                 1440             


Glu Gln  Ile Thr Asn Ala Trp  Val Gln Val Ser Gly  Asp Glu Ala 
    1445                 1450                 1455             


Glu Asn  Cys Ile His Lys Lys  Arg Glu His Ile Glu  Asn Asp His 
    1460                 1465                 1470             


Phe Lys  Val Ala Ser Pro Leu  Glu Thr Cys Leu Leu  Glu Leu Glu 
    1475                 1480                 1485             


Val Ser  Pro Val Lys Met Leu  Phe Gln Lys Lys Tyr  Asp Leu Asn 
    1490                 1495                 1500             


Glu Leu  Cys Thr Trp Phe Met  Gln Thr Thr Glu Thr  Gln Ser Leu 
    1505                 1510                 1515             


Ser Leu  Val Arg Lys Ala Asn  Ala Arg Asn Pro Leu  Glu Val Ile 
    1520                 1525                 1530             


Asn Thr  Arg Gly Ile Lys Leu  Gly Thr Lys Tyr Ser  Asp Phe Asn 
    1535                 1540                 1545             


Ala Ser  Pro Phe Arg Lys His  Phe Lys Lys Phe Ala  Leu Ser Ser 
    1550                 1555                 1560             


Pro Ser  Lys Ser Ala Glu Lys  Leu His Ile Leu His  Lys Val Ala 
    1565                 1570                 1575             


Asn Ser  Pro Leu Leu Asn Val  Lys Ser Asn Leu Ala  Ile Ala Arg 
    1580                 1585                 1590             


Leu Lys  Arg Thr Glu Phe Lys  Arg Leu His His Glu  Arg Trp Lys 
    1595                 1600                 1605             


Arg Glu  Gly Lys Leu His Asn  His Gly Thr Val Asp  Trp Asn Ser 
    1610                 1615                 1620             


Lys Arg  Arg Asn Leu Arg Phe  Phe Cys Gln Asn Gln  Phe Leu Asn 
    1625                 1630                 1635             


Lys Thr  Glu Gly Glu Thr Asn  Ala Asp Ile Pro Leu  Gln Gly Lys 
    1640                 1645                 1650             


Ser Ile  Val Asp Asn Gln Cys  Val Leu Pro Pro Glu  Ile Arg Gly 
    1655                 1660                 1665             


Asp Leu  Gln Gln Arg Val Val  Met Pro Asp Phe Lys  Ile His Ala 
    1670                 1675                 1680             


Ser Phe  Glu Asn Lys Phe Lys  Ser Glu Ala Lys Glu  Asn Gly Thr 
    1685                 1690                 1695             


Asn Cys  Ser Gln Lys Asp Phe  Gln Lys Gly Pro Arg  Leu Glu Asn 
    1700                 1705                 1710             


Val Cys  Pro Asn Ser Trp Arg  Ser Lys Thr Leu Lys  Asp Cys Arg 
    1715                 1720                 1725             


Ile Phe  Leu Arg Lys Leu Asn  Cys Leu Glu His Arg  Asn Thr Phe 
    1730                 1735                 1740             


Lys Leu  Asn Thr Ile Ile Tyr  Ser Pro Glu Ser Thr  Asp Ser Gly 
    1745                 1750                 1755             


Asn Thr  His Gln Thr His Met  Glu Glu Ser Lys Arg  Phe Thr Leu 
    1760                 1765                 1770             


Arg Ser  His Ser Ala Arg Gln  Asn Ser Phe Lys Lys  Gln Ser Lys 
    1775                 1780                 1785             


Glu Ile  Glu Asn Ala Asn Thr  Asn Asn Pro Ser Ala  Asp Glu Phe 
    1790                 1795                 1800             


Ala Asp  His Leu Gly Asn Ser  Lys Leu Ser Lys Cys  Val Asn Phe 
    1805                 1810                 1815             


Asp Lys  Asn Pro Asp Ser Phe  Glu Val Leu Ser Asn  Leu Asn Lys 
    1820                 1825                 1830             


Arg Lys  Arg Pro Pro Trp Lys  Ile Thr Glu Met Ser  Thr Lys Arg 
    1835                 1840                 1845             


His Lys  Arg Gln Ser Cys Asn  Ser Gly Gln Met Ala  Asn Tyr Phe 
    1850                 1855                 1860             


Ser Lys  Ser Leu Ala Cys Tyr  Lys 
    1865                 1870     


<210>  7760
<211>  79
<212>  PRT
<213>  Homo Sapiens

<400>  7760

Met Asp Lys Gly Arg Glu Arg Met Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Ala Ala Ala Gln Cys Arg Ser Pro Arg Cys Ala Ala Glu 
            20                  25                  30          


Arg Arg Gly Phe Arg Arg Glu Leu Asp Ser Trp Arg His Arg Leu Met 
        35                  40                  45              


His Cys Val Gly Phe Glu Ser Ile Leu Glu Gly Leu Tyr Gly Pro Arg 
    50                  55                  60                  


Leu Arg Arg Asp Leu Ser Leu Phe Glu Gly Leu Tyr Thr Ile Ser 
65                  70                  75                  


<210>  7761
<211>  77
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7761

Xaa Gly Arg Glu Arg Met Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Ala Gln Cys Arg Ser Pro Arg Cys Ala Ala Glu Arg Arg 
            20                  25                  30          


Gly Phe Arg Arg Glu Leu Asp Ser Trp Arg His Arg Leu Met His Cys 
        35                  40                  45              


Val Gly Phe Glu Ser Ile Leu Glu Gly Leu Tyr Gly Pro Arg Leu Arg 
    50                  55                  60                  


Arg Asp Leu Ser Leu Phe Glu Gly Leu Tyr Thr Ile Ser 
65                  70                  75          


<210>  7762
<211>  692
<212>  PRT
<213>  Homo Sapiens

<400>  7762

Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe 
            20                  25                  30          


Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly 
        35                  40                  45              


Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu 
    50                  55                  60                  


Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn 
65                  70                  75                  80  


Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp 
                85                  90                  95      


Asn Gly Ser Asp Glu Gln Gly Cys Leu Thr Leu Cys Glu Gly Pro Asn 
            100                 105                 110         


Lys Phe Lys Cys His Ser Gly Glu Cys Ile Thr Leu Asp Lys Val Cys 
        115                 120                 125             


Asn Met Ala Arg Asp Cys Arg Asp Trp Ser Asp Glu Pro Ile Lys Glu 
    130                 135                 140                 


Cys Gly Thr Asn Glu Cys Leu Asp Asn Asn Gly Gly Cys Ser His Val 
145                 150                 155                 160 


Cys Asn Asp Leu Lys Ile Gly Tyr Glu Cys Leu Cys Pro Asp Gly Phe 
                165                 170                 175     


Gln Leu Val Ala Gln Arg Arg Cys Glu Asp Ile Asp Glu Cys Gln Asp 
            180                 185                 190         


Pro Asp Thr Cys Ser Gln Leu Cys Val Asn Leu Glu Gly Gly Tyr Lys 
        195                 200                 205             


Cys Gln Cys Glu Glu Gly Phe Gln Leu Asp Pro His Thr Lys Ala Cys 
    210                 215                 220                 


Lys Ala Val Gly Ser Ile Ala Tyr Leu Phe Phe Thr Asn Arg His Glu 
225                 230                 235                 240 


Val Arg Lys Met Thr Leu Asp Arg Ser Glu Tyr Thr Ser Leu Ile Pro 
                245                 250                 255     


Asn Leu Arg Asn Val Val Ala Leu Asp Thr Glu Val Ala Ser Asn Arg 
            260                 265                 270         


Ile Tyr Trp Ser Asp Leu Ser Gln Arg Met Ile Cys Ser Thr Gln Leu 
        275                 280                 285             


Asp Arg Ala His Gly Val Ser Ser Tyr Asp Thr Val Ile Ser Arg Asp 
    290                 295                 300                 


Ile Gln Ala Pro Asp Gly Leu Ala Val Asp Trp Ile His Ser Asn Ile 
305                 310                 315                 320 


Tyr Trp Thr Asp Ser Val Leu Gly Thr Val Ser Val Ala Asp Thr Lys 
                325                 330                 335     


Gly Val Lys Arg Lys Thr Leu Phe Arg Glu Asn Gly Ser Lys Pro Arg 
            340                 345                 350         


Ala Ile Val Val Asp Pro Val His Gly Phe Met Tyr Trp Thr Asp Trp 
        355                 360                 365             


Gly Thr Pro Ala Lys Ile Lys Lys Gly Gly Leu Asn Gly Val Asp Ile 
    370                 375                 380                 


Tyr Ser Leu Val Thr Glu Asn Ile Gln Trp Pro Asn Gly Ile Thr Leu 
385                 390                 395                 400 


Asp Leu Leu Ser Gly Arg Leu Tyr Trp Val Asp Ser Lys Leu His Ser 
                405                 410                 415     


Ile Ser Ser Ile Asp Val Asn Gly Gly Asn Arg Lys Thr Ile Leu Glu 
            420                 425                 430         


Asp Glu Lys Arg Leu Ala His Pro Phe Ser Leu Ala Val Phe Glu Asp 
        435                 440                 445             


Lys Val Phe Trp Thr Asp Ile Ile Asn Glu Ala Ile Phe Ser Ala Asn 
    450                 455                 460                 


Arg Leu Thr Gly Ser Asp Val Asn Leu Leu Ala Glu Asn Leu Leu Ser 
465                 470                 475                 480 


Pro Glu Asp Met Val Leu Phe His Asn Leu Thr Gln Pro Arg Gly Val 
                485                 490                 495     


Asn Trp Cys Glu Arg Thr Thr Leu Ser Asn Gly Gly Cys Gln Tyr Leu 
            500                 505                 510         


Cys Leu Pro Ala Pro Gln Ile Asn Pro His Ser Pro Lys Phe Thr Cys 
        515                 520                 525             


Ala Cys Pro Asp Gly Met Leu Leu Ala Arg Asp Met Arg Ser Cys Leu 
    530                 535                 540                 


Thr Glu Ala Glu Ala Ala Val Ala Thr Gln Glu Thr Ser Thr Val Arg 
545                 550                 555                 560 


Leu Lys Val Ser Ser Thr Ala Val Arg Thr Gln His Thr Thr Thr Arg 
                565                 570                 575     


Pro Val Pro Asp Thr Ser Arg Leu Pro Gly Ala Thr Pro Gly Leu Thr 
            580                 585                 590         


Thr Val Glu Ile Val Thr Met Ser His Gln Ala Leu Gly Asp Val Ala 
        595                 600                 605             


Gly Arg Gly Asn Glu Lys Lys Pro Ser Ser Val Arg Ala Leu Ser Ile 
    610                 615                 620                 


Val Leu Pro Ile Val Leu Leu Val Phe Leu Cys Leu Gly Val Phe Leu 
625                 630                 635                 640 


Leu Trp Lys Asn Trp Arg Leu Lys Asn Ile Asn Ser Ile Asn Phe Asp 
                645                 650                 655     


Asn Pro Val Tyr Gln Lys Thr Thr Glu Asp Glu Val His Ile Cys His 
            660                 665                 670         


Asn Gln Asp Gly Tyr Ser Tyr Pro Ser Arg Gln Met Val Ser Leu Glu 
        675                 680                 685             


Asp Asp Val Ala 
    690         


<210>  7763
<211>  860
<212>  PRT
<213>  Homo Sapiens

<400>  7763

Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe 
            20                  25                  30          


Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly 
        35                  40                  45              


Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu 
    50                  55                  60                  


Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn 
65                  70                  75                  80  


Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp 
                85                  90                  95      


Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp 
            100                 105                 110         


Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys 
        115                 120                 125             


Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro 
    130                 135                 140                 


Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys 
145                 150                 155                 160 


Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly 
                165                 170                 175     


Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly 
            180                 185                 190         


Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu 
        195                 200                 205             


Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp 
    210                 215                 220                 


Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu 
225                 230                 235                 240 


Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp 
                245                 250                 255     


Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn 
            260                 265                 270         


Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu 
        275                 280                 285             


Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp 
    290                 295                 300                 


Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp 
305                 310                 315                 320 


Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr 
                325                 330                 335     


Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys 
            340                 345                 350         


Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys 
        355                 360                 365             


Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln 
    370                 375                 380                 


Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr 
385                 390                 395                 400 


Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg 
                405                 410                 415     


Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu 
            420                 425                 430         


Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln 
        435                 440                 445             


Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser 
    450                 455                 460                 


Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala 
465                 470                 475                 480 


Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly 
                485                 490                 495     


Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe 
            500                 505                 510         


Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His 
        515                 520                 525             


Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys 
    530                 535                 540                 


Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile 
545                 550                 555                 560 


Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr 
                565                 570                 575     


Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly 
            580                 585                 590         


Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro 
        595                 600                 605             


Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile 
    610                 615                 620                 


Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn 
625                 630                 635                 640 


Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His 
                645                 650                 655     


Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu 
            660                 665                 670         


Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn 
        675                 680                 685             


Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu 
    690                 695                 700                 


Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala 
705                 710                 715                 720 


Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val 
                725                 730                 735     


Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu 
            740                 745                 750         


Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser 
        755                 760                 765             


His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro 
    770                 775                 780                 


Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val 
785                 790                 795                 800 


Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys 
                805                 810                 815     


Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr 
            820                 825                 830         


Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro 
        835                 840                 845             


Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala 
    850                 855                 860 


<210>  7764
<211>  858
<212>  PRT
<213>  Homo Sapiens

<400>  7764

Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe 
            20                  25                  30          


Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly 
        35                  40                  45              


Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu 
    50                  55                  60                  


Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn 
65                  70                  75                  80  


Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp 
                85                  90                  95      


Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp 
            100                 105                 110         


Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys 
        115                 120                 125             


Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro 
    130                 135                 140                 


Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys 
145                 150                 155                 160 


Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly 
                165                 170                 175     


Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly 
            180                 185                 190         


Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu 
        195                 200                 205             


Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp 
    210                 215                 220                 


Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu 
225                 230                 235                 240 


Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp 
                245                 250                 255     


Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn 
            260                 265                 270         


Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu 
        275                 280                 285             


Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp 
    290                 295                 300                 


Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp 
305                 310                 315                 320 


Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr 
                325                 330                 335     


Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys 
            340                 345                 350         


Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys 
        355                 360                 365             


Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln 
    370                 375                 380                 


Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr 
385                 390                 395                 400 


Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg 
                405                 410                 415     


Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu 
            420                 425                 430         


Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln 
        435                 440                 445             


Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser 
    450                 455                 460                 


Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala 
465                 470                 475                 480 


Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly 
                485                 490                 495     


Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe 
            500                 505                 510         


Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His 
        515                 520                 525             


Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys 
    530                 535                 540                 


Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile 
545                 550                 555                 560 


Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr 
                565                 570                 575     


Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly 
            580                 585                 590         


Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro 
        595                 600                 605             


Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile 
    610                 615                 620                 


Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn 
625                 630                 635                 640 


Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His 
                645                 650                 655     


Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu 
            660                 665                 670         


Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn 
        675                 680                 685             


Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu 
    690                 695                 700                 


Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala 
705                 710                 715                 720 


Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val 
                725                 730                 735     


Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu 
            740                 745                 750         


Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser 
        755                 760                 765             


His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro 
    770                 775                 780                 


Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val 
785                 790                 795                 800 


Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys 
                805                 810                 815     


Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr 
            820                 825                 830         


Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro 
        835                 840                 845             


Ser Met Val Ser Leu Glu Asp Asp Val Ala 
    850                 855             


<210>  7765
<211>  948
<212>  PRT
<213>  Homo Sapiens

<400>  7765

Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe 
            20                  25                  30          


Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly 
        35                  40                  45              


Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu 
    50                  55                  60                  


Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn 
65                  70                  75                  80  


Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp 
                85                  90                  95      


Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp 
            100                 105                 110         


Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys 
        115                 120                 125             


Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro 
    130                 135                 140                 


Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys 
145                 150                 155                 160 


Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly 
                165                 170                 175     


Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly 
            180                 185                 190         


Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu 
        195                 200                 205             


Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp 
    210                 215                 220                 


Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu 
225                 230                 235                 240 


Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp 
                245                 250                 255     


Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn 
            260                 265                 270         


Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu 
        275                 280                 285             


Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp 
    290                 295                 300                 


Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp 
305                 310                 315                 320 


Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr 
                325                 330                 335     


Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys 
            340                 345                 350         


Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys 
        355                 360                 365             


Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln 
    370                 375                 380                 


Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr 
385                 390                 395                 400 


Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg 
                405                 410                 415     


Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu 
            420                 425                 430         


Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln 
        435                 440                 445             


Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser 
    450                 455                 460                 


Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala 
465                 470                 475                 480 


Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly 
                485                 490                 495     


Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe 
            500                 505                 510         


Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His 
        515                 520                 525             


Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys 
    530                 535                 540                 


Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile 
545                 550                 555                 560 


Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr 
                565                 570                 575     


Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly 
            580                 585                 590         


Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro 
        595                 600                 605             


Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile 
    610                 615                 620                 


Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn 
625                 630                 635                 640 


Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His 
                645                 650                 655     


Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu 
            660                 665                 670         


Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn 
        675                 680                 685             


Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu 
    690                 695                 700                 


Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala 
705                 710                 715                 720 


Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val 
                725                 730                 735     


Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu 
            740                 745                 750         


Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser 
        755                 760                 765             


His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro 
    770                 775                 780                 


Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Ala Thr Glu Leu 
785                 790                 795                 800 


Gly Leu Trp Ser Arg Gly Gln Leu Cys Asp Arg Ala Cys Leu Ser Leu 
                805                 810                 815     


Gln Cys Ser Ser Ser Ser Phe Ala Trp Gly Ser Ser Phe Tyr Gly Arg 
            820                 825                 830         


Thr Gly Gly Leu Arg Thr Ser Thr Ala Ser Thr Leu Thr Thr Pro Ser 
        835                 840                 845             


Ile Arg Arg Pro Gln Arg Met Arg Ser Thr Phe Ala Thr Thr Arg Thr 
    850                 855                 860                 


Ala Thr Ala Thr Pro Arg Asp Arg Trp Ser Val Trp Arg Met Thr Trp 
865                 870                 875                 880 


Arg Glu His Leu Pro Gly Val Pro Ser Leu Pro Arg Thr Leu Pro Glu 
                885                 890                 895     


Thr Ser Pro Ala Leu Phe Tyr Ser Lys Thr Glu Lys Thr Lys Ala Leu 
            900                 905                 910         


Pro Ala Arg Ala Leu Phe Tyr Ile Phe Ile His Leu Gly Gly Arg Thr 
        915                 920                 925             


Gly Phe Gly Gln Cys Pro Cys Asn Gly Leu Gly Trp Asp Phe Gly Phe 
    930                 935                 940                 


Phe Leu Ser Ser 
945             


<210>  7766
<211>  682
<212>  PRT
<213>  Homo Sapiens

<400>  7766

Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe 
            20                  25                  30          


Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly 
        35                  40                  45              


Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu 
    50                  55                  60                  


Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn 
65                  70                  75                  80  


Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp 
                85                  90                  95      


Asn Gly Ser Asp Glu Gln Gly Cys Pro Val Ala Thr Cys Arg Pro Asp 
            100                 105                 110         


Glu Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys 
        115                 120                 125             


Asp Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val 
    130                 135                 140                 


Asn Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly 
145                 150                 155                 160 


Glu Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg 
                165                 170                 175     


Asp Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu 
            180                 185                 190         


Asp Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly 
        195                 200                 205             


Tyr Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg 
    210                 215                 220                 


Cys Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu 
225                 230                 235                 240 


Cys Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe 
                245                 250                 255     


Gln Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala 
            260                 265                 270         


Tyr Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp 
        275                 280                 285             


Arg Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala 
    290                 295                 300                 


Leu Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser 
305                 310                 315                 320 


Gln Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser 
                325                 330                 335     


Ser Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu 
            340                 345                 350         


Ala Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu 
        355                 360                 365             


Gly Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu 
    370                 375                 380                 


Phe Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val 
385                 390                 395                 400 


His Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys 
                405                 410                 415     


Lys Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn 
            420                 425                 430         


Ile Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu 
        435                 440                 445             


Tyr Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn 
    450                 455                 460                 


Gly Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His 
465                 470                 475                 480 


Pro Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile 
                485                 490                 495     


Ile Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val 
            500                 505                 510         


Asn Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe 
        515                 520                 525             


His Asn Leu Thr Gln Pro Arg Glu Ala Glu Ala Ala Val Ala Thr Gln 
    530                 535                 540                 


Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val Arg Thr 
545                 550                 555                 560 


Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu Pro Gly 
                565                 570                 575     


Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser His Gln 
            580                 585                 590         


Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro Ser Ser 
        595                 600                 605             


Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val Phe Leu 
    610                 615                 620                 


Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys Asn Ile 
625                 630                 635                 640 


Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr Glu Asp 
                645                 650                 655     


Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro Ser Arg 
            660                 665                 670         


Gln Met Val Ser Leu Glu Asp Asp Val Ala 
        675                 680         


<210>  7767
<211>  819
<212>  PRT
<213>  Homo Sapiens

<400>  7767

Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe 
            20                  25                  30          


Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly 
        35                  40                  45              


Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Ser 
    50                  55                  60                  


Pro Lys Thr Cys Ser Gln Asp Glu Phe Arg Cys His Asp Gly Lys Cys 
65                  70                  75                  80  


Ile Ser Arg Gln Phe Val Cys Asp Ser Asp Arg Asp Cys Leu Asp Gly 
                85                  90                  95      


Ser Asp Glu Ala Ser Cys Pro Val Leu Thr Cys Gly Pro Ala Ser Phe 
            100                 105                 110         


Gln Cys Asn Ser Ser Thr Cys Ile Pro Gln Leu Trp Ala Cys Asp Asn 
        115                 120                 125             


Asp Pro Asp Cys Glu Asp Gly Ser Asp Glu Trp Pro Gln Arg Cys Arg 
    130                 135                 140                 


Gly Leu Tyr Val Phe Gln Gly Asp Ser Ser Pro Cys Ser Ala Phe Glu 
145                 150                 155                 160 


Phe His Cys Leu Ser Gly Glu Cys Ile His Ser Ser Trp Arg Cys Asp 
                165                 170                 175     


Gly Gly Pro Asp Cys Lys Asp Lys Ser Asp Glu Glu Asn Cys Ala Val 
            180                 185                 190         


Ala Thr Cys Arg Pro Asp Glu Phe Gln Cys Ser Asp Gly Asn Cys Ile 
        195                 200                 205             


His Gly Ser Arg Gln Cys Asp Arg Glu Tyr Asp Cys Lys Asp Met Ser 
    210                 215                 220                 


Asp Glu Val Gly Cys Val Asn Val Thr Leu Cys Glu Gly Pro Asn Lys 
225                 230                 235                 240 


Phe Lys Cys His Ser Gly Glu Cys Ile Thr Leu Asp Lys Val Cys Asn 
                245                 250                 255     


Met Ala Arg Asp Cys Arg Asp Trp Ser Asp Glu Pro Ile Lys Glu Cys 
            260                 265                 270         


Gly Thr Asn Glu Cys Leu Asp Asn Asn Gly Gly Cys Ser His Val Cys 
        275                 280                 285             


Asn Asp Leu Lys Ile Gly Tyr Glu Cys Leu Cys Pro Asp Gly Phe Gln 
    290                 295                 300                 


Leu Val Ala Gln Arg Arg Cys Glu Asp Ile Asp Glu Cys Gln Asp Pro 
305                 310                 315                 320 


Asp Thr Cys Ser Gln Leu Cys Val Asn Leu Glu Gly Gly Tyr Lys Cys 
                325                 330                 335     


Gln Cys Glu Glu Gly Phe Gln Leu Asp Pro His Thr Lys Ala Cys Lys 
            340                 345                 350         


Ala Val Gly Ser Ile Ala Tyr Leu Phe Phe Thr Asn Arg His Glu Val 
        355                 360                 365             


Arg Lys Met Thr Leu Asp Arg Ser Glu Tyr Thr Ser Leu Ile Pro Asn 
    370                 375                 380                 


Leu Arg Asn Val Val Ala Leu Asp Thr Glu Val Ala Ser Asn Arg Ile 
385                 390                 395                 400 


Tyr Trp Ser Asp Leu Ser Gln Arg Met Ile Cys Ser Thr Gln Leu Asp 
                405                 410                 415     


Arg Ala His Gly Val Ser Ser Tyr Asp Thr Val Ile Ser Arg Asp Ile 
            420                 425                 430         


Gln Ala Pro Asp Gly Leu Ala Val Asp Trp Ile His Ser Asn Ile Tyr 
        435                 440                 445             


Trp Thr Asp Ser Val Leu Gly Thr Val Ser Val Ala Asp Thr Lys Gly 
    450                 455                 460                 


Val Lys Arg Lys Thr Leu Phe Arg Glu Asn Gly Ser Lys Pro Arg Ala 
465                 470                 475                 480 


Ile Val Val Asp Pro Val His Gly Phe Met Tyr Trp Thr Asp Trp Gly 
                485                 490                 495     


Thr Pro Ala Lys Ile Lys Lys Gly Gly Leu Asn Gly Val Asp Ile Tyr 
            500                 505                 510         


Ser Leu Val Thr Glu Asn Ile Gln Trp Pro Asn Gly Ile Thr Leu Asp 
        515                 520                 525             


Leu Leu Ser Gly Arg Leu Tyr Trp Val Asp Ser Lys Leu His Ser Ile 
    530                 535                 540                 


Ser Ser Ile Asp Val Asn Gly Gly Asn Arg Lys Thr Ile Leu Glu Asp 
545                 550                 555                 560 


Glu Lys Arg Leu Ala His Pro Phe Ser Leu Ala Val Phe Glu Asp Lys 
                565                 570                 575     


Val Phe Trp Thr Asp Ile Ile Asn Glu Ala Ile Phe Ser Ala Asn Arg 
            580                 585                 590         


Leu Thr Gly Ser Asp Val Asn Leu Leu Ala Glu Asn Leu Leu Ser Pro 
        595                 600                 605             


Glu Asp Met Val Leu Phe His Asn Leu Thr Gln Pro Arg Gly Val Asn 
    610                 615                 620                 


Trp Cys Glu Arg Thr Thr Leu Ser Asn Gly Gly Cys Gln Tyr Leu Cys 
625                 630                 635                 640 


Leu Pro Ala Pro Gln Ile Asn Pro His Ser Pro Lys Phe Thr Cys Ala 
                645                 650                 655     


Cys Pro Asp Gly Met Leu Leu Ala Arg Asp Met Arg Ser Cys Leu Thr 
            660                 665                 670         


Glu Ala Glu Ala Ala Val Ala Thr Gln Glu Thr Ser Thr Val Arg Leu 
        675                 680                 685             


Lys Val Ser Ser Thr Ala Val Arg Thr Gln His Thr Thr Thr Arg Pro 
    690                 695                 700                 


Val Pro Asp Thr Ser Arg Leu Pro Gly Ala Thr Pro Gly Leu Thr Thr 
705                 710                 715                 720 


Val Glu Ile Val Thr Met Ser His Gln Ala Leu Gly Asp Val Ala Gly 
                725                 730                 735     


Arg Gly Asn Glu Lys Lys Pro Ser Ser Val Arg Ala Leu Ser Ile Val 
            740                 745                 750         


Leu Pro Ile Val Leu Leu Val Phe Leu Cys Leu Gly Val Phe Leu Leu 
        755                 760                 765             


Trp Lys Asn Trp Arg Leu Lys Asn Ile Asn Ser Ile Asn Phe Asp Asn 
    770                 775                 780                 


Pro Val Tyr Gln Lys Thr Thr Glu Asp Glu Val His Ile Cys His Asn 
785                 790                 795                 800 


Gln Asp Gly Tyr Ser Tyr Pro Ser Arg Gln Met Val Ser Leu Glu Asp 
                805                 810                 815     


Asp Val Ala 
            


<210>  7768
<211>  945
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7768

Xaa Gly Arg Pro Gly Val Pro Pro Arg Phe Leu Ser Gln Arg Arg Arg 
1               5                   10                  15      


Gln Val Pro Gly Pro Arg Ser Arg Leu Arg Asp Ile His Glu Ser Pro 
            20                  25                  30          


Ser Val Ile Leu Gly Pro Pro Gly Glu Val Pro Gly Phe Arg Cys Ala 
        35                  40                  45              


Leu Trp Arg His Leu Arg Pro His Leu Val Leu Gly Gly Ala Leu Ala 
    50                  55                  60                  


Pro Pro Ala Pro Ile Lys Phe Thr Glu Gly Pro Pro Ala Thr Leu Lys 
65                  70                  75                  80  


Ala Ser Val Pro Tyr Glu Val Glu Thr Leu Pro Gln Asn Leu Pro Ala 
                85                  90                  95      


Pro Pro Trp Ser Ala Ala Glu Ile Phe Ser His Val Gly Asp Arg Cys 
            100                 105                 110         


Glu Arg Asn Glu Phe Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys 
        115                 120                 125             


Trp Val Cys Asp Gly Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser 
    130                 135                 140                 


Gln Glu Thr Cys Leu Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys 
145                 150                 155                 160 


Gly Gly Arg Val Asn Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly 
                165                 170                 175     


Gln Val Asp Cys Asp Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys 
            180                 185                 190         


Thr Cys Ser Gln Asp Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser 
        195                 200                 205             


Arg Gln Phe Val Cys Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp 
    210                 215                 220                 


Glu Ala Ser Cys Pro Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys 
225                 230                 235                 240 


Asn Ser Ser Thr Cys Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro 
                245                 250                 255     


Asp Cys Glu Asp Gly Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu 
            260                 265                 270         


Tyr Val Phe Gln Gly Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His 
        275                 280                 285             


Cys Leu Ser Gly Glu Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly 
    290                 295                 300                 


Pro Asp Cys Lys Asp Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr 
305                 310                 315                 320 


Cys Arg Pro Asp Glu Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly 
                325                 330                 335     


Ser Arg Gln Cys Asp Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu 
            340                 345                 350         


Val Gly Cys Val Asn Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys 
        355                 360                 365             


Cys His Ser Gly Glu Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala 
    370                 375                 380                 


Arg Asp Cys Arg Asp Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr 
385                 390                 395                 400 


Asn Glu Cys Leu Asp Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp 
                405                 410                 415     


Leu Lys Ile Gly Tyr Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val 
            420                 425                 430         


Ala Gln Arg Arg Cys Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr 
        435                 440                 445             


Cys Ser Gln Leu Cys Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys 
    450                 455                 460                 


Glu Glu Gly Phe Gln Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val 
465                 470                 475                 480 


Gly Ser Ile Ala Tyr Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys 
                485                 490                 495     


Met Thr Leu Asp Arg Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg 
            500                 505                 510         


Asn Val Val Ala Leu Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp 
        515                 520                 525             


Ser Asp Leu Ser Gln Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala 
    530                 535                 540                 


His Gly Val Ser Ser Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala 
545                 550                 555                 560 


Pro Asp Gly Leu Ala Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr 
                565                 570                 575     


Asp Ser Val Leu Gly Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys 
            580                 585                 590         


Arg Lys Thr Leu Phe Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val 
        595                 600                 605             


Val Asp Pro Val His Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro 
    610                 615                 620                 


Ala Lys Ile Lys Lys Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu 
625                 630                 635                 640 


Val Thr Glu Asn Ile Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu 
                645                 650                 655     


Ser Gly Arg Leu Tyr Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser 
            660                 665                 670         


Ile Asp Val Asn Gly Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys 
        675                 680                 685             


Arg Leu Ala His Pro Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe 
    690                 695                 700                 


Trp Thr Asp Ile Ile Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr 
705                 710                 715                 720 


Gly Ser Asp Val Asn Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp 
                725                 730                 735     


Met Val Leu Phe His Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys 
            740                 745                 750         


Glu Arg Thr Thr Leu Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro 
        755                 760                 765             


Ala Pro Gln Ile Asn Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro 
    770                 775                 780                 


Asp Gly Met Leu Leu Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala 
785                 790                 795                 800 


Glu Ala Ala Val Ala Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val 
                805                 810                 815     


Ser Ser Thr Ala Val Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro 
            820                 825                 830         


Asp Thr Ser Arg Leu Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu 
        835                 840                 845             


Ile Val Thr Met Ser His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly 
    850                 855                 860                 


Asn Glu Lys Lys Pro Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro 
865                 870                 875                 880 


Ile Val Leu Leu Val Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys 
                885                 890                 895     


Asn Trp Arg Leu Lys Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val 
            900                 905                 910         


Tyr Gln Lys Thr Thr Glu Asp Glu Val His Ile Cys His Asn Gln Asp 
        915                 920                 925             


Gly Tyr Ser Tyr Pro Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val 
    930                 935                 940                 


Ala 
945 


<210>  7769
<211>  309
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7769

Xaa Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro Val Leu Thr Cys Gly 
1               5                   10                  15      


Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys Ile Pro Gln Leu Trp 
            20                  25                  30          


Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly Ser Asp Glu Trp Pro 
        35                  40                  45              


Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly Asp Ser Ser Pro Cys 
    50                  55                  60                  


Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu Cys Ile His Ser Ser 
65                  70                  75                  80  


Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp Lys Ser Asp Glu Glu 
                85                  90                  95      


Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu Phe Gln Cys Ser Asp 
            100                 105                 110         


Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp Arg Glu Tyr Asp Cys 
        115                 120                 125             


Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn Val Thr Leu Cys Glu 
    130                 135                 140                 


Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu Cys Ile Thr Leu Asp 
145                 150                 155                 160 


Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp Trp Ser Asp Glu Pro 
                165                 170                 175     


Ile Lys Glu Cys Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser 
            180                 185                 190         


Gln Leu Cys Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu 
        195                 200                 205             


Gly Phe Gln Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser 
    210                 215                 220                 


Ile Ala Tyr Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr 
225                 230                 235                 240 


Leu Asp Arg Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val 
                245                 250                 255     


Val Ala Leu Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp 
            260                 265                 270         


Leu Ser Gln Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly 
        275                 280                 285             


Val Ser Ser Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp 
    290                 295                 300                 


Gly Leu Ala Val Asp 
305                 


<210>  7770
<211>  170
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7770

Xaa Asn Val Val Ala Leu Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr 
1               5                   10                  15      


Trp Ser Asp Leu Ser Gln Arg Met Ile Cys Ser Thr Gln Leu Asp Arg 
            20                  25                  30          


Ala His Gly Val Ser Ser Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln 
        35                  40                  45              


Ala Pro Asp Gly Leu Ala Val Asp Trp Ile His Ser Asn Ile Tyr Trp 
    50                  55                  60                  


Thr Asp Ser Val Leu Gly Thr Val Ser Val Ala Asp Thr Lys Gly Val 
65                  70                  75                  80  


Lys Arg Lys Thr Leu Phe Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile 
                85                  90                  95      


Val Val Asp Pro Val His Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr 
            100                 105                 110         


Pro Ala Lys Ile Lys Lys Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser 
        115                 120                 125             


Leu Val Thr Glu Asn Ile Gln Trp Pro Asn Gly Ile Thr Leu Gly Gln 
    130                 135                 140                 


Ser Ile Leu Asp Arg Tyr His Gln Arg Ser His Phe Gln Cys Gln Pro 
145                 150                 155                 160 


Pro His Arg Phe Arg Cys Gln Leu Val Gly 
                165                 170 


<210>  7771
<211>  272
<212>  PRT
<213>  Homo Sapiens

<400>  7771

Met Glu Ala Cys Cys Leu Leu Gln Leu Pro Gln Arg Leu Leu Leu Leu 
1               5                   10                  15      


Gly Ala Ala Ala Leu Thr Ala Thr Ala Leu Glu Thr Ala Asp Leu Ala 
            20                  25                  30          


Glu Leu Cys Gly Gln Thr Trp Gln Gly Asp Gly Leu Leu Leu Arg Ser 
        35                  40                  45              


His Ala Ala Ser Arg Arg Phe Tyr Phe Val Ala Pro Asp Thr Asp Cys 
    50                  55                  60                  


Gly Leu Trp Val Gln Ala Ala Ala Pro Gly Asp Arg Ile Arg Phe Gln 
65                  70                  75                  80  


Phe Arg Phe Phe Leu Val Tyr Ser Leu Thr Pro Ala Pro Pro Ala Leu 
                85                  90                  95      


Asn Thr Ser Ser Pro Ala Pro Ala Asp Pro Cys Ala Pro Gly Ser Tyr 
            100                 105                 110         


Leu Gln Phe Tyr Glu Gly Pro Pro Gly Ala Pro Arg Pro Leu Gly Ser 
        115                 120                 125             


Pro Leu Cys Gly Leu Asn Ile Pro Val Pro Val Ala Ser Ser Gly Pro 
    130                 135                 140                 


Phe Leu Gly Leu Arg Leu Val Thr Arg Gly Arg Gln Pro Arg Val Asp 
145                 150                 155                 160 


Phe Val Gly Glu Val Thr Ser Phe Arg Leu Gly Pro Cys Gly Ala Tyr 
                165                 170                 175     


Phe Arg Cys Gln Asn Gly Arg Cys Ile Pro Ser Ser Leu Val Cys Asp 
            180                 185                 190         


Pro Trp Gly Met Asp Asn Cys Gly Asp Gly Ser Asp Gln Gly Ser Trp 
        195                 200                 205             


Ser Pro Ala Asp Cys Arg Gly Pro Ser Pro Val Pro Ser Gln Thr Gly 
    210                 215                 220                 


Ser Thr Asp Ala His Thr Ser Arg Ser Leu Thr Pro Ser Pro Ala Leu 
225                 230                 235                 240 


Gly Ser Ala Gly Ser Leu Trp Ile Ala Ala Glu Arg Ser Ser Pro Ala 
                245                 250                 255     


Gly Arg Asp Pro Thr Arg Gln Asp Ala Ala Leu Glu Gly Ser Thr Glu 
            260                 265                 270         


<210>  7772
<211>  272
<212>  PRT
<213>  Homo Sapiens

<400>  7772

Met Glu Ala Cys Cys Leu Leu Gln Leu Pro Gln Arg Leu Leu Leu Leu 
1               5                   10                  15      


Gly Ala Ala Ala Leu Thr Ala Thr Ala Leu Glu Thr Ala Asp Leu Ala 
            20                  25                  30          


Glu Leu Cys Gly Gln Thr Trp Gln Gly Asp Gly Leu Leu Leu Arg Ser 
        35                  40                  45              


His Ala Ala Ser Arg Arg Phe Tyr Phe Val Ala Pro Asp Thr Asp Cys 
    50                  55                  60                  


Gly Leu Trp Val Gln Ala Ala Ala Pro Gly Asp Arg Ile Arg Phe Gln 
65                  70                  75                  80  


Phe Arg Phe Phe Leu Val Tyr Ser Leu Thr Pro Ala Pro Pro Ala Leu 
                85                  90                  95      


Asn Thr Ser Ser Pro Ala Pro Ala Asp Pro Cys Ala Pro Gly Ser Tyr 
            100                 105                 110         


Leu Gln Phe Tyr Glu Gly Pro Pro Gly Ala Pro Arg Pro Leu Gly Ser 
        115                 120                 125             


Pro Leu Cys Gly Leu Asn Ile Pro Val Pro Val Ala Ser Ser Gly Pro 
    130                 135                 140                 


Phe Leu Gly Leu Arg Leu Val Thr Arg Gly Arg Gln Pro Arg Val Asp 
145                 150                 155                 160 


Phe Val Gly Glu Val Thr Ser Phe Arg Leu Gly Pro Cys Gly Ala Tyr 
                165                 170                 175     


Phe Arg Cys Gln Asn Gly Arg Cys Ile Pro Ser Ser Leu Val Cys Asp 
            180                 185                 190         


Pro Trp Gly Met Asp Asn Cys Gly Asp Gly Ser Asp Gln Gly Ser Trp 
        195                 200                 205             


Ser Pro Ala Asp Cys Arg Gly Pro Ser Pro Val Pro Ser Gln Thr Gly 
    210                 215                 220                 


Ser Thr Asp Ala His Thr Ser Arg Ser Leu Thr Pro Ser Pro Ala Leu 
225                 230                 235                 240 


Gly Ser Ala Gly Ser Leu Trp Ile Ala Ala Glu Arg Ser Ser Pro Ala 
                245                 250                 255     


Gly Arg Asp Pro Thr Arg Gln Asp Ala Ala Leu Glu Gly Ser Thr Glu 
            260                 265                 270         


<210>  7773
<211>  77
<212>  PRT
<213>  Homo Sapiens

<400>  7773

Met Trp His Leu Lys Leu Cys Ala Val Leu Met Ile Phe Leu Leu Leu 
1               5                   10                  15      


Leu Gly Gln Ile Asp Gly Ser Pro Ile Pro Glu Val Ser Ser Ala Lys 
            20                  25                  30          


Arg Arg Pro Arg Arg Met Thr Pro Phe Trp Arg Gly Val Ser Leu Arg 
        35                  40                  45              


Pro Ile Gly Ala Ser Cys Arg Asp Asp Ser Glu Cys Ile Thr Arg Leu 
    50                  55                  60                  


Cys Arg Lys Arg Arg Cys Ser Leu Ser Val Ala Gln Glu 
65                  70                  75          


<210>  7774
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  7774

Met Phe Ser Thr Lys Ala Leu Leu Leu Ala Gly Leu Ile Ser Thr Ala 
1               5                   10                  15      


Leu Ala Gly Pro Trp Ala Asn Ile Cys Ala Gly Lys Ser Ser Asn Glu 
            20                  25                  30          


Ile Arg Thr Cys Asp Arg His Gly Cys Gly Gln Tyr Ser Ala Gln Arg 
        35                  40                  45              


Ser Gln Arg Pro His Gln Gly Val Asp Ile Leu Cys Ser Ala Gly Ser 
    50                  55                  60                  


Thr Val Tyr Ala Pro Phe Thr Gly Met Ile Val Gly Gln Glu Lys Pro 
65                  70                  75                  80  


Tyr Gln Asn Lys Asn Ala Ile Asn Asn Gly Val Arg Ile Ser Gly Arg 
                85                  90                  95      


Glu Ile Thr Thr Asp Thr Pro Ile Phe Asn Asn Tyr Tyr Pro Asp Gln 
            100                 105                 110         


Ser Ala Ala Val Asn Ile Lys Thr Arg Ser Ser Thr Ser Lys Lys Met 
        115                 120                 125             


Met Thr His 
    130     


<210>  7775
<211>  151
<212>  PRT
<213>  Homo Sapiens

<400>  7775

Met Phe Ser Thr Lys Ala Leu Leu Leu Ala Gly Leu Ile Ser Thr Ala 
1               5                   10                  15      


Leu Ala Gly Pro Trp Ala Asn Ile Cys Ala Gly Lys Ser Ser Asn Glu 
            20                  25                  30          


Ile Arg Thr Cys Asp Arg His Gly Cys Gly Gln Tyr Ser Ala Gln Arg 
        35                  40                  45              


Ser Gln Arg Pro His Gln Gly Val Asp Ile Leu Cys Ser Ala Gly Ser 
    50                  55                  60                  


Thr Val Tyr Ala Pro Phe Thr Gly Met Ile Val Gly Gln Glu Lys Pro 
65                  70                  75                  80  


Tyr Gln Asn Lys Asn Ala Ile Asn Asn Gly Val Arg Ile Ser Gly Arg 
                85                  90                  95      


Gly Phe Cys Val Lys Met Phe Tyr Ile Lys Pro Ile Lys Tyr Lys Gly 
            100                 105                 110         


Pro Ile Lys Lys Gly Glu Lys Leu Gly Thr Leu Leu Pro Leu Gln Lys 
        115                 120                 125             


Val Tyr Pro Gly Ile Gln Ser His Val His Ile Glu Asn Cys Asp Ser 
    130                 135                 140                 


Ser Asp Pro Thr Ala Tyr Leu 
145                 150     


<210>  7776
<211>  111
<212>  PRT
<213>  Homo Sapiens

<400>  7776

Met Phe Ser Thr Lys Ala Leu Leu Leu Ala Gly Leu Ile Ser Thr Ala 
1               5                   10                  15      


Leu Ala Gly Pro Trp Ala Asn Ile Cys Ala Gly Lys Ser Ser Asn Glu 
            20                  25                  30          


Ile Arg Thr Cys Asp Arg His Gly Cys Gly Gln Tyr Ser Ala Gln Arg 
        35                  40                  45              


Ser Gln Arg Pro His Gln Gly Val Asp Ile Leu Cys Ser Ala Gly Ser 
    50                  55                  60                  


Thr Val Tyr Ala Pro Phe Thr Gly Met Ile Val Gly Gln Glu Lys Pro 
65                  70                  75                  80  


Tyr Gln Asn Lys Asn Ala Ile Asn Asn Gly Val Arg Ile Ser Gly Arg 
                85                  90                  95      


Gly Lys Arg Gly Gly Val Tyr Thr Trp Gly Ala Ser Trp Arg Cys 
            100                 105                 110     


<210>  7777
<211>  79
<212>  PRT
<213>  Homo Sapiens

<400>  7777

Met Ile Val Gly Gln Glu Lys Pro Tyr Gln Asn Lys Asn Ala Ile Asn 
1               5                   10                  15      


Asn Gly Val Arg Ile Ser Gly Arg Gly Phe Cys Val Lys Met Phe Tyr 
            20                  25                  30          


Ile Lys Pro Ile Lys Tyr Lys Gly Pro Ile Lys Lys Gly Glu Lys Leu 
        35                  40                  45              


Gly Thr Leu Leu Pro Leu Gln Lys Val Tyr Pro Gly Ile Gln Ser His 
    50                  55                  60                  


Val His Ile Glu Asn Cys Asp Ser Ser Asp Pro Thr Ala Tyr Leu 
65                  70                  75                  


<210>  7778
<211>  64
<212>  PRT
<213>  Homo Sapiens

<400>  7778

Met Glu Gln Arg Leu Pro Pro Asn Ser Glu Leu Val Gln Ala Val Leu 
1               5                   10                  15      


Arg Leu Phe Gln Glu Pro Val Pro Lys Ala Ala Leu His Arg His Gly 
            20                  25                  30          


Arg Leu Ser Pro Arg Ser Ala Arg Ala Arg Val Thr Val Glu Trp Leu 
        35                  40                  45              


Arg Val Arg Asp Asp Gly Ser Asn Arg Thr Ser Leu Ile Asp Ser Arg 
    50                  55                  60                  


<210>  7779
<211>  366
<212>  PRT
<213>  Homo Sapiens

<400>  7779

Met Gln Pro Leu Trp Leu Cys Trp Ala Leu Trp Val Leu Pro Leu Ala 
1               5                   10                  15      


Ser Pro Gly Ala Ala Leu Thr Gly Glu Gln Leu Leu Gly Ser Leu Leu 
            20                  25                  30          


Arg Gln Leu Gln Leu Lys Glu Val Pro Thr Leu Asp Arg Ala Asp Met 
        35                  40                  45              


Glu Glu Leu Val Ile Pro Thr His Val Arg Ala Gln Tyr Val Ala Leu 
    50                  55                  60                  


Leu Gln Arg Ser His Gly Asp Arg Ser Arg Gly Lys Arg Phe Ser Gln 
65                  70                  75                  80  


Ser Phe Arg Glu Val Ala Gly Arg Phe Leu Ala Leu Glu Ala Ser Thr 
                85                  90                  95      


His Leu Leu Val Phe Gly Met Glu Gln Arg Leu Pro Pro Asn Ser Glu 
            100                 105                 110         


Leu Val Gln Ala Val Leu Arg Leu Phe Gln Glu Pro Val Pro Lys Ala 
        115                 120                 125             


Ala Leu His Arg His Gly Arg Leu Ser Pro Arg Ser Ala Arg Ala Arg 
    130                 135                 140                 


Val Thr Val Glu Trp Leu Arg Val Arg Asp Asp Gly Ser Asn Arg Thr 
145                 150                 155                 160 


Ser Leu Ile Asp Ser Arg Leu Val Ser Val His Glu Ser Gly Trp Lys 
                165                 170                 175     


Ala Phe Asp Val Thr Glu Ala Val Asn Phe Trp Gln Gln Leu Ser Arg 
            180                 185                 190         


Pro Arg Gln Pro Leu Leu Leu Gln Val Ser Val Gln Arg Glu His Leu 
        195                 200                 205             


Gly Pro Leu Ala Ser Gly Ala His Lys Leu Val Arg Phe Ala Ser Gln 
    210                 215                 220                 


Gly Ala Pro Ala Gly Leu Gly Glu Pro Gln Leu Glu Leu His Thr Leu 
225                 230                 235                 240 


Asp Leu Gly Asp Tyr Gly Ala Gln Gly Asp Cys Asp Pro Glu Ala Pro 
                245                 250                 255     


Met Thr Glu Gly Thr Arg Cys Cys Arg Gln Glu Met Tyr Ile Asp Leu 
            260                 265                 270         


Gln Gly Met Lys Trp Ala Glu Asn Trp Val Leu Glu Pro Pro Gly Phe 
        275                 280                 285             


Leu Ala Tyr Glu Cys Val Gly Thr Cys Arg Gln Pro Pro Glu Ala Leu 
    290                 295                 300                 


Ala Phe Lys Trp Pro Phe Leu Gly Pro Arg Gln Cys Ile Ala Ser Glu 
305                 310                 315                 320 


Thr Asp Ser Leu Pro Met Ile Val Ser Ile Lys Glu Gly Gly Arg Thr 
                325                 330                 335     


Arg Pro Gln Val Val Ser Leu Pro Asn Met Arg Val Gln Lys Cys Ser 
            340                 345                 350         


Cys Ala Ser Asp Gly Ala Leu Val Pro Arg Arg Leu Gln Pro 
        355                 360                 365     


<210>  7780
<211>  332
<212>  PRT
<213>  Homo Sapiens

<400>  7780

Met Trp Pro Leu Trp Leu Cys Trp Ala Leu Trp Val Leu Pro Leu Ala 
1               5                   10                  15      


Gly Pro Gly Ala Ala Leu Thr Glu Glu Gln Leu Leu Gly Ser Leu Leu 
            20                  25                  30          


Arg Gln Leu Gln Leu Ser Glu Val Pro Val Leu Asp Arg Ala Asp Met 
        35                  40                  45              


Glu Lys Leu Val Ile Pro Ala His Val Arg Ala Gln Tyr Val Val Leu 
    50                  55                  60                  


Leu Arg Arg Ser His Gly Asp Arg Ser Arg Gly Lys Arg Phe Ser Gln 
65                  70                  75                  80  


Ser Phe Arg Glu Val Ala Gly Arg Phe Leu Ala Ser Glu Ala Ala Leu 
                85                  90                  95      


His Arg His Gly Arg Leu Ser Pro Arg Ser Ala Gln Ala Arg Val Thr 
            100                 105                 110         


Val Glu Trp Leu Arg Val Arg Asp Asp Gly Ser Asn Arg Thr Ser Leu 
        115                 120                 125             


Ile Asp Ser Arg Leu Val Ser Val His Glu Ser Gly Trp Lys Ala Phe 
    130                 135                 140                 


Asp Val Thr Glu Ala Val Asn Phe Trp Gln Gln Leu Ser Arg Pro Arg 
145                 150                 155                 160 


Gln Pro Leu Leu Leu Gln Val Ser Val Gln Arg Glu His Leu Gly Pro 
                165                 170                 175     


Leu Ala Ser Gly Ala His Lys Leu Val Arg Phe Ala Ser Gln Gly Ala 
            180                 185                 190         


Pro Ala Gly Leu Gly Glu Pro Gln Leu Glu Leu His Thr Leu Asp Leu 
        195                 200                 205             


Arg Asp Tyr Gly Ala Gln Gly Asp Cys Asp Pro Glu Ala Pro Met Thr 
    210                 215                 220                 


Glu Gly Thr Arg Cys Cys Arg Gln Glu Met Tyr Ile Asp Leu Gln Gly 
225                 230                 235                 240 


Met Lys Trp Ala Lys Asn Trp Val Leu Glu Pro Pro Gly Phe Leu Ala 
                245                 250                 255     


Tyr Glu Cys Val Gly Thr Cys Gln Gln Pro Pro Glu Ala Leu Ala Phe 
            260                 265                 270         


Asn Trp Pro Phe Leu Gly Pro Arg Gln Cys Ile Ala Ser Glu Thr Ala 
        275                 280                 285             


Ser Leu Pro Met Ile Val Ser Ile Lys Glu Gly Gly Arg Thr Arg Pro 
    290                 295                 300                 


Gln Val Val Ser Leu Pro Asn Met Arg Val Gln Lys Cys Ser Cys Ala 
305                 310                 315                 320 


Ser Asp Gly Ala Leu Val Pro Arg Arg Leu Gln Pro 
                325                 330         


<210>  7781
<211>  366
<212>  PRT
<213>  Homo Sapiens

<400>  7781

Met Trp Pro Leu Trp Leu Cys Trp Ala Leu Trp Val Leu Pro Leu Ala 
1               5                   10                  15      


Gly Pro Gly Ala Ala Leu Thr Glu Glu Gln Leu Leu Gly Ser Leu Leu 
            20                  25                  30          


Arg Gln Leu Gln Leu Ser Glu Val Pro Val Leu Asp Arg Ala Asp Met 
        35                  40                  45              


Glu Lys Leu Val Ile Pro Ala His Val Arg Ala Gln Tyr Val Val Leu 
    50                  55                  60                  


Leu Arg Arg Ser His Gly Asp Arg Ser Arg Gly Lys Arg Phe Ser Gln 
65                  70                  75                  80  


Ser Phe Arg Glu Val Ala Gly Arg Phe Leu Ala Ser Glu Ala Ser Thr 
                85                  90                  95      


His Leu Leu Val Phe Gly Met Glu Gln Arg Leu Pro Pro Asn Ser Glu 
            100                 105                 110         


Leu Val Gln Ala Val Leu Arg Leu Phe Gln Glu Pro Val Pro Lys Ala 
        115                 120                 125             


Ala Leu His Arg His Gly Arg Leu Ser Pro Arg Ser Ala Gln Ala Arg 
    130                 135                 140                 


Val Thr Val Glu Trp Leu Arg Val Arg Asp Asp Gly Ser Asn Arg Thr 
145                 150                 155                 160 


Ser Leu Ile Asp Ser Arg Leu Val Ser Val His Glu Ser Gly Trp Lys 
                165                 170                 175     


Ala Phe Asp Val Thr Glu Ala Val Asn Phe Trp Gln Gln Leu Ser Arg 
            180                 185                 190         


Pro Arg Gln Pro Leu Leu Leu Gln Val Ser Val Gln Arg Glu His Leu 
        195                 200                 205             


Gly Pro Leu Ala Ser Gly Ala His Lys Leu Val Arg Phe Ala Ser Gln 
    210                 215                 220                 


Gly Ala Pro Ala Gly Leu Gly Glu Pro Gln Leu Glu Leu His Thr Leu 
225                 230                 235                 240 


Asp Leu Arg Asp Tyr Gly Ala Gln Gly Asp Cys Asp Pro Glu Ala Pro 
                245                 250                 255     


Met Thr Glu Gly Thr Arg Cys Cys Arg Gln Glu Met Tyr Ile Asp Leu 
            260                 265                 270         


Gln Gly Met Lys Trp Ala Lys Asn Trp Val Leu Glu Pro Pro Gly Phe 
        275                 280                 285             


Leu Ala Tyr Glu Cys Val Gly Thr Cys Gln Gln Pro Pro Glu Ala Leu 
    290                 295                 300                 


Ala Phe Asn Trp Pro Phe Leu Gly Pro Arg Gln Cys Ile Ala Ser Glu 
305                 310                 315                 320 


Thr Ala Ser Leu Pro Met Ile Val Ser Ile Lys Glu Gly Gly Arg Thr 
                325                 330                 335     


Arg Pro Gln Val Val Ser Leu Pro Asn Met Arg Val Gln Lys Cys Ser 
            340                 345                 350         


Cys Ala Ser Asp Gly Ala Leu Val Pro Arg Arg Leu Gln Pro 
        355                 360                 365     


<210>  7782
<211>  167
<212>  PRT
<213>  Homo Sapiens

<400>  7782

Met His Trp Gly Thr Leu Cys Gly Phe Leu Trp Leu Trp Pro Tyr Leu 
1               5                   10                  15      


Phe Tyr Val Gln Ala Val Pro Ile Gln Lys Val Gln Asp Asp Thr Lys 
            20                  25                  30          


Thr Leu Ile Lys Thr Ile Val Thr Arg Ile Asn Asp Ile Ser His Thr 
        35                  40                  45              


Gln Ser Val Ser Ser Lys Gln Lys Val Thr Gly Leu Asp Phe Ile Pro 
    50                  55                  60                  


Gly Leu His Pro Ile Leu Thr Leu Ser Lys Met Asp Gln Thr Leu Ala 
65                  70                  75                  80  


Val Tyr Gln Gln Ile Leu Thr Ser Met Pro Ser Arg Asn Val Ile Gln 
                85                  90                  95      


Ile Ser Asn Asp Leu Glu Asn Leu Arg Asp Leu Leu His Val Leu Ala 
            100                 105                 110         


Phe Ser Lys Ser Cys His Leu Pro Trp Ala Ser Gly Leu Glu Thr Leu 
        115                 120                 125             


Asp Ser Leu Gly Gly Val Leu Glu Ala Ser Gly Tyr Ser Thr Glu Val 
    130                 135                 140                 


Val Ala Leu Ser Arg Leu Gln Gly Ser Leu Gln Asp Met Leu Trp Gln 
145                 150                 155                 160 


Leu Asp Leu Ser Pro Gly Cys 
                165         


<210>  7783
<211>  308
<212>  PRT
<213>  Homo Sapiens

<400>  7783

Met Asp Glu Gln Thr Gly Arg Leu Arg Leu Asp Thr Tyr Cys Met Ser 
1               5                   10                  15      


Ala Lys Gln Ile Trp Ala Trp Ser Lys Cys Ser Gly Arg Leu Trp Asp 
            20                  25                  30          


Glu His Met Lys Trp Met Glu Gly Trp Thr Asp Arg Trp Thr Asp Gly 
        35                  40                  45              


Trp Met Asp Gly Trp Met Asp Glu Trp Ser Pro Thr Pro Ala Leu Arg 
    50                  55                  60                  


Ser Tyr Gly Gly Gly Leu Ser Gln Gln Thr Phe Ile Phe Thr Asp Gly 
65                  70                  75                  80  


Glu Asp Glu Ala Leu Ala Arg His Thr Gly Asn Val Val Ile Thr Asn 
                85                  90                  95      


Cys Ser Ala Ala His Ser Arg Gln Ala Leu Ser Cys Lys Met Ala Val 
            100                 105                 110         


Glu Tyr Asp Arg Phe Ile Glu Ser Gly Arg Lys Trp Phe Cys His Val 
        115                 120                 125             


Asp Asp Asp Asn Tyr Val Asn Leu Arg Ala Leu Leu Arg Leu Leu Ala 
    130                 135                 140                 


Ser Tyr Pro His Thr Arg Asp Val Tyr Val Gly Lys Pro Ser Leu Asp 
145                 150                 155                 160 


Arg Pro Ile Gln Ala Met Glu Arg Val Ser Glu Asn Lys Val Arg Pro 
                165                 170                 175     


Val His Phe Trp Phe Ala Thr Gly Gly Ala Gly Phe Cys Ile Ser Arg 
            180                 185                 190         


Gly Leu Ala Leu Lys Met Ser Pro Trp Ala Ser Gly Gly His Phe Met 
        195                 200                 205             


Asn Thr Ala Glu Arg Ile Arg Leu Pro Asp Asp Cys Thr Ile Gly Tyr 
    210                 215                 220                 


Ile Val Glu Ala Leu Leu Gly Val Pro Leu Ile Arg Ser Gly Leu Phe 
225                 230                 235                 240 


His Ser His Leu Glu Asn Leu Gln Gln Val Pro Thr Ser Glu Leu His 
                245                 250                 255     


Glu Gln Val Thr Leu Ser Tyr Gly Met Phe Glu Asn Lys Arg Asn Ala 
            260                 265                 270         


Val His Val Lys Gly Pro Phe Ser Val Glu Ala Asp Pro Ser Arg Phe 
        275                 280                 285             


Arg Ser Ile His Cys His Leu Tyr Pro Asp Thr Pro Trp Cys Pro Arg 
    290                 295                 300                 


Thr Ala Ile Phe 
305             


<210>  7784
<211>  248
<212>  PRT
<213>  Homo Sapiens

<400>  7784

Met Lys Gly Cys Leu Leu Lys Ala Asp Phe Leu Leu Gln Thr Phe Ile 
1               5                   10                  15      


Phe Thr Asp Gly Glu Asp Glu Ala Leu Ala Arg His Thr Gly Asn Val 
            20                  25                  30          


Val Ile Thr Asn Cys Ser Ala Ala His Ser Arg Gln Ala Leu Ser Cys 
        35                  40                  45              


Lys Met Ala Val Glu Tyr Asp Arg Phe Ile Glu Ser Gly Arg Lys Trp 
    50                  55                  60                  


Phe Cys His Val Asp Asp Asp Asn Tyr Val Asn Leu Arg Ala Leu Leu 
65                  70                  75                  80  


Arg Leu Leu Ala Ser Tyr Pro His Thr Arg Asp Val Tyr Val Gly Lys 
                85                  90                  95      


Pro Ser Leu Asp Arg Pro Ile Gln Ala Met Glu Arg Val Ser Glu Asn 
            100                 105                 110         


Lys Val Arg Pro Val His Phe Trp Phe Ala Thr Gly Gly Ala Gly Phe 
        115                 120                 125             


Cys Ile Ser Arg Gly Leu Ala Leu Lys Met Ser Pro Trp Ala Ser Gly 
    130                 135                 140                 


Gly His Phe Met Asn Thr Ala Glu Arg Ile Arg Leu Pro Asp Asp Cys 
145                 150                 155                 160 


Thr Ile Gly Tyr Ile Val Glu Ala Leu Leu Gly Val Pro Leu Ile Arg 
                165                 170                 175     


Ser Gly Leu Phe His Ser His Leu Glu Asn Leu Gln Gln Val Pro Thr 
            180                 185                 190         


Ser Glu Leu His Glu Gln Val Thr Leu Ser Tyr Gly Met Phe Glu Asn 
        195                 200                 205             


Lys Arg Asn Ala Val His Val Lys Gly Pro Phe Ser Val Glu Ala Asp 
    210                 215                 220                 


Pro Ser Arg Phe Arg Ser Ile His Cys His Leu Tyr Pro Asp Thr Pro 
225                 230                 235                 240 


Trp Cys Pro Arg Thr Ala Ile Phe 
                245             


<210>  7785
<211>  379
<212>  PRT
<213>  Homo Sapiens

<400>  7785

Met Leu Lys Arg Cys Gly Arg Arg Leu Leu Leu Ala Leu Ala Gly Ala 
1               5                   10                  15      


Leu Leu Ala Cys Leu Leu Val Leu Thr Ala Asp Pro Pro Pro Pro Pro 
            20                  25                  30          


Leu Pro Ala Glu Arg Gly Arg Arg Ala Leu Arg Ser Leu Ala Gly Pro 
        35                  40                  45              


Ala Gly Ala Ala Pro Ala Pro Gly Leu Gly Ala Ala Ala Ala Ala Pro 
    50                  55                  60                  


Gly Ala Leu Val Arg Asp Val His Ser Leu Ser Glu Tyr Phe Ser Leu 
65                  70                  75                  80  


Leu Thr Arg Ala Arg Arg Asp Ala Gly Pro Pro Pro Gly Ala Ala Pro 
                85                  90                  95      


Arg Pro Ala Asp Gly His Pro Arg Pro Leu Ala Glu Pro Leu Ala Pro 
            100                 105                 110         


Arg Asp Val Phe Ile Ala Val Lys Thr Thr Lys Lys Phe His Arg Ala 
        115                 120                 125             


Arg Leu Asp Leu Leu Leu Glu Thr Trp Ile Ser Arg His Lys Glu Met 
    130                 135                 140                 


Thr Phe Ile Phe Thr Asp Gly Glu Asp Glu Ala Leu Ala Arg His Thr 
145                 150                 155                 160 


Gly Asn Val Val Ile Thr Asn Cys Ser Ala Ala His Ser Arg Gln Ala 
                165                 170                 175     


Leu Ser Cys Lys Met Ala Val Glu Tyr Asp Arg Phe Ile Glu Ser Gly 
            180                 185                 190         


Arg Lys Trp Phe Cys His Val Asp Asp Asp Asn Tyr Val Asn Leu Arg 
        195                 200                 205             


Ala Leu Leu Arg Leu Leu Ala Ser Tyr Pro His Thr Arg Asp Val Tyr 
    210                 215                 220                 


Val Gly Lys Pro Ser Leu Asp Arg Pro Ile Gln Ala Met Glu Arg Val 
225                 230                 235                 240 


Ser Glu Asn Lys Val Arg Pro Val His Phe Trp Phe Ala Thr Gly Gly 
                245                 250                 255     


Ala Gly Phe Cys Ile Ser Arg Gly Leu Ala Leu Lys Met Ser Pro Trp 
            260                 265                 270         


Ala Ser Gly Gly His Phe Met Asn Thr Ala Glu Arg Ile Arg Leu Pro 
        275                 280                 285             


Asp Asp Cys Thr Ile Gly Tyr Ile Val Glu Ala Leu Leu Gly Val Pro 
    290                 295                 300                 


Leu Ile Arg Ser Gly Leu Phe His Ser His Leu Glu Asn Leu Gln Gln 
305                 310                 315                 320 


Val Pro Thr Ser Glu Leu His Glu Gln Val Thr Leu Ser Tyr Gly Met 
                325                 330                 335     


Phe Glu Asn Lys Arg Asn Ala Val His Val Lys Gly Pro Phe Ser Val 
            340                 345                 350         


Glu Ala Asp Pro Ser Arg Phe Arg Ser Ile His Cys His Leu Tyr Pro 
        355                 360                 365             


Asp Thr Pro Trp Cys Pro Arg Thr Ala Ile Phe 
    370                 375                 


<210>  7786
<211>  361
<212>  PRT
<213>  Homo Sapiens

<400>  7786

Met Leu Lys Arg Cys Gly Arg Arg Leu Leu Leu Ala Leu Ala Gly Ala 
1               5                   10                  15      


Leu Leu Ala Cys Leu Leu Val Leu Thr Ala Asp Pro Pro Pro Pro Pro 
            20                  25                  30          


Leu Pro Ala Glu Arg Gly Arg Arg Ala Leu Arg Ser Leu Ala Gly Pro 
        35                  40                  45              


Ala Gly Ala Ala Pro Ala Pro Gly Leu Gly Ala Ala Ala Ala Ala Pro 
    50                  55                  60                  


Gly Ala Leu Val Arg Asp Val His Ser Leu Ser Glu Tyr Phe Ser Leu 
65                  70                  75                  80  


Leu Thr Arg Ala Arg Arg Asp Ala Gly Pro Pro Pro Gly Ala Ala Pro 
                85                  90                  95      


Arg Pro Ala Asp Gly His Pro Arg Pro Leu Ala Glu Pro Leu Ala Pro 
            100                 105                 110         


Arg Asp Val Phe Ile Ala Val Lys Thr Thr Lys Lys Phe His Arg Ala 
        115                 120                 125             


Arg Leu Asp Leu Leu Leu Glu Thr Trp Ile Ser Arg His Lys Glu Met 
    130                 135                 140                 


Thr Phe Ile Phe Thr Asp Gly Glu Asp Glu Ala Leu Ala Arg His Thr 
145                 150                 155                 160 


Gly Asn Val Val Ile Thr Asn Cys Ser Ala Ala His Ser Arg Gln Ala 
                165                 170                 175     


Leu Ser Cys Lys Met Ala Val Glu Tyr Asp Arg Phe Ile Glu Ser Gly 
            180                 185                 190         


Arg Lys Trp Phe Cys His Val Asp Asp Asp Asn Tyr Val Asn Leu Arg 
        195                 200                 205             


Ala Leu Leu Arg Leu Leu Ala Ser Tyr Pro His Thr Arg Asp Val Tyr 
    210                 215                 220                 


Val Gly Lys Pro Ser Leu Asp Arg Pro Ile Gln Ala Met Glu Arg Val 
225                 230                 235                 240 


Ser Glu Asn Lys Val Arg Pro Val His Phe Trp Phe Ala Thr Gly Gly 
                245                 250                 255     


Ala Gly Phe Cys Ile Ser Arg Gly Leu Ala Leu Lys Met Ser Pro Trp 
            260                 265                 270         


Ala Ser Gly Gly His Phe Met Asn Thr Ala Glu Arg Ile Arg Leu Pro 
        275                 280                 285             


Asp Asp Cys Thr Ile Gly Tyr Ile Val Glu Ala Leu Leu Gly Val Pro 
    290                 295                 300                 


Leu Ile Arg Ser Gly Leu Phe His Ser His Leu Glu Asn Leu Gln Gln 
305                 310                 315                 320 


Val Pro Thr Ser Glu Leu His Glu Gln Val Thr Leu Ser Tyr Gly Met 
                325                 330                 335     


Phe Glu Asn Lys Arg Asn Ala Val His Val Lys Gly Pro Phe Ser Val 
            340                 345                 350         


Glu Ala Asp Pro Ser Arg Trp Gly Asn 
        355                 360     


<210>  7787
<211>  250
<212>  PRT
<213>  Homo Sapiens

<400>  7787

Met Thr Pro Gly Arg Cys Cys Leu Ala Ala Asp Ile Gln Val Glu Thr 
1               5                   10                  15      


Phe Ile Phe Thr Asp Gly Glu Asp Glu Ala Leu Ala Arg His Thr Gly 
            20                  25                  30          


Asn Val Val Ile Thr Asn Cys Ser Ala Ala His Ser Arg Gln Ala Leu 
        35                  40                  45              


Ser Cys Lys Met Ala Val Glu Tyr Asp Arg Phe Ile Glu Ser Gly Arg 
    50                  55                  60                  


Lys Trp Phe Cys His Val Asp Asp Asp Asn Tyr Val Asn Leu Arg Ala 
65                  70                  75                  80  


Leu Leu Arg Leu Leu Ala Ser Tyr Pro His Thr Arg Asp Val Tyr Val 
                85                  90                  95      


Gly Lys Pro Ser Leu Asp Arg Pro Ile Gln Ala Met Glu Arg Val Ser 
            100                 105                 110         


Glu Asn Lys Val Arg Pro Val His Phe Trp Phe Ala Thr Gly Gly Ala 
        115                 120                 125             


Gly Phe Cys Ile Ser Arg Gly Leu Ala Leu Lys Met Ser Pro Trp Ala 
    130                 135                 140                 


Ser Gly Gly His Phe Met Asn Thr Ala Glu Arg Ile Arg Leu Pro Asp 
145                 150                 155                 160 


Asp Cys Thr Ile Gly Tyr Ile Val Glu Ala Leu Leu Gly Val Pro Leu 
                165                 170                 175     


Ile Arg Ser Gly Leu Phe His Ser His Leu Glu Asn Leu Gln Gln Val 
            180                 185                 190         


Pro Thr Ser Glu Leu His Glu Gln Val Thr Leu Ser Tyr Gly Met Phe 
        195                 200                 205             


Glu Asn Lys Arg Asn Ala Val His Val Lys Gly Pro Phe Ser Val Glu 
    210                 215                 220                 


Ala Asp Pro Ser Arg Phe Arg Ser Ile His Cys His Leu Tyr Pro Asp 
225                 230                 235                 240 


Thr Pro Trp Cys Pro Arg Thr Ala Ile Phe 
                245                 250 


<210>  7788
<211>  250
<212>  PRT
<213>  Homo Sapiens

<400>  7788

Met Thr Pro Gly Arg Cys Cys Leu Ala Ala Asp Ile Gln Val Glu Thr 
1               5                   10                  15      


Phe Ile Phe Thr Asp Gly Glu Asp Glu Ala Leu Ala Arg His Thr Gly 
            20                  25                  30          


Asn Val Val Ile Thr Asn Cys Ser Ala Ala His Ser Arg Gln Ala Leu 
        35                  40                  45              


Ser Cys Lys Met Ala Val Glu Tyr Asp Arg Phe Ile Glu Ser Gly Arg 
    50                  55                  60                  


Lys Trp Phe Cys His Val Asp Asp Asp Asn Tyr Val Asn Leu Arg Ala 
65                  70                  75                  80  


Leu Leu Arg Leu Leu Ala Ser Tyr Pro His Thr Arg Asp Val Tyr Val 
                85                  90                  95      


Gly Lys Pro Ser Leu Asp Arg Pro Ile Gln Ala Met Glu Arg Val Ser 
            100                 105                 110         


Glu Asn Lys Val Arg Pro Val His Phe Trp Phe Ala Thr Gly Gly Ala 
        115                 120                 125             


Gly Phe Cys Ile Ser Arg Gly Leu Ala Leu Lys Met Ser Pro Trp Ala 
    130                 135                 140                 


Ser Gly Gly His Phe Met Asn Thr Ala Glu Arg Ile Arg Leu Pro Asp 
145                 150                 155                 160 


Asp Cys Thr Ile Gly Tyr Ile Val Glu Ala Leu Leu Gly Val Pro Leu 
                165                 170                 175     


Ile Arg Ser Gly Leu Phe His Ser His Leu Glu Asn Leu Gln Gln Val 
            180                 185                 190         


Pro Thr Ser Glu Leu His Glu Gln Val Thr Leu Ser Tyr Gly Met Phe 
        195                 200                 205             


Glu Asn Lys Arg Asn Ala Val His Val Lys Gly Pro Phe Ser Val Glu 
    210                 215                 220                 


Ala Asp Pro Ser Arg Phe Arg Ser Ile His Cys His Leu Tyr Pro Asp 
225                 230                 235                 240 


Thr Pro Trp Cys Pro Arg Thr Ala Ile Phe 
                245                 250 


<210>  7789
<211>  18
<212>  PRT
<213>  Homo Sapiens

<400>  7789

Met Thr Pro Pro Arg Leu Phe Trp Val Trp Leu Leu Val Ala Gly Thr 
1               5                   10                  15      


Gln Ala 
        


<210>  7790
<211>  41
<212>  PRT
<213>  Homo Sapiens

<400>  7790

Met Thr Pro Pro Arg Leu Phe Trp Val Trp Leu Leu Val Ala Gly Thr 
1               5                   10                  15      


Gln Ala Pro Gly Ile Pro Ser Asp Asp Asp Leu Glu Val Pro Gly Gly 
            20                  25                  30          


Ser Pro Gly Phe Arg Arg Glu Arg Trp 
        35                  40      


<210>  7791
<211>  41
<212>  PRT
<213>  Homo Sapiens

<400>  7791

Met Thr Pro Pro Arg Leu Phe Trp Val Trp Leu Leu Val Ala Gly Thr 
1               5                   10                  15      


Gln Ala Pro Gly Ile Pro Ser Asp Asp Asp Leu Glu Val Pro Gly Gly 
            20                  25                  30          


Ser Pro Gly Phe Arg Arg Glu Arg Trp 
        35                  40      


<210>  7792
<211>  62
<212>  PRT
<213>  Homo Sapiens

<400>  7792

Met Thr Pro Pro Arg Leu Phe Trp Val Trp Leu Leu Val Ala Gly Thr 
1               5                   10                  15      


Gln Gly Glu Leu Ser Pro Trp Glu Ile Pro Lys Ala Glu Val Trp Lys 
            20                  25                  30          


Ala Gly Ala Pro Trp Gly Cys Ser Glu Leu Gln Gly Asp Ile Leu Pro 
        35                  40                  45              


Gly Ala Arg Gly Pro Ala Val Ser Gln Ile Phe Ser Pro Ala 
    50                  55                  60          


<210>  7793
<211>  62
<212>  PRT
<213>  Homo Sapiens

<400>  7793

Met Thr Pro Pro Arg Leu Phe Trp Val Trp Leu Leu Val Ala Gly Thr 
1               5                   10                  15      


Gln Gly Glu Leu Ser Pro Trp Glu Ile Pro Lys Ala Glu Val Trp Lys 
            20                  25                  30          


Ala Gly Ala Pro Trp Gly Cys Ser Glu Leu Gln Gly Asp Ile Leu Pro 
        35                  40                  45              


Gly Ala Arg Gly Pro Ala Val Ser Gln Ile Phe Ser Pro Ala 
    50                  55                  60          


<210>  7794
<211>  144
<212>  PRT
<213>  Homo Sapiens

<400>  7794

Met Thr Pro Pro Arg Leu Phe Trp Val Trp Leu Leu Val Ala Gly Thr 
1               5                   10                  15      


Gln Gly Ser Gly Pro Ile Met Leu Asp Glu Val Gln Cys Thr Gly Thr 
            20                  25                  30          


Glu Ala Ser Leu Ala Asp Cys Lys Ser Leu Gly Trp Leu Lys Ser Asn 
        35                  40                  45              


Cys Arg His Glu Arg Asp Ala Gly Val Val Cys Thr Asn Glu Thr Arg 
    50                  55                  60                  


Ser Thr His Thr Leu Asp Leu Ser Arg Glu Leu Ser Glu Ala Leu Gly 
65                  70                  75                  80  


Gln Ile Phe Asp Ser Gln Arg Gly Cys Asp Leu Ser Ile Ser Val Asn 
                85                  90                  95      


Val Gln Gly Glu Asp Ala Leu Gly Phe Cys Gly His Thr Val Ile Leu 
            100                 105                 110         


Thr Ala Asn Leu Glu Ala Gln Ala Leu Trp Lys Glu Pro Gly Ser Asn 
        115                 120                 125             


Val Thr Met Ser Val Asp Ala Glu Cys Val Pro Met Val Arg Asp Leu 
    130                 135                 140                 


<210>  7795
<211>  48
<212>  PRT
<213>  Homo Sapiens

<400>  7795

Met Thr Pro Pro Arg Leu Phe Trp Val Trp Leu Leu Val Ala Gly Thr 
1               5                   10                  15      


Gln Gly Val Asn Asp Gly Asp Met Arg Leu Ala Asp Gly Gly Ala Thr 
            20                  25                  30          


Asn Gln Gly Arg Val Glu Ile Phe Tyr Arg Gly Pro Trp Pro Asp Leu 
        35                  40                  45              


<210>  7796
<211>  113
<212>  PRT
<213>  Homo Sapiens

<400>  7796

Met Thr Pro Pro Arg Leu Phe Trp Val Trp Leu Leu Val Ala Gly Thr 
1               5                   10                  15      


Gln Gly Val Asn Asp Gly Asp Met Arg Leu Ala Asp Gly Gly Ala Thr 
            20                  25                  30          


Asn Gln Gly Arg Val Glu Ile Phe Tyr Arg Gly Gln Trp Gly Thr Val 
        35                  40                  45              


Cys Asp Asn Leu Trp Asp Leu Thr Asp Ala Ser Val Val Cys Arg Ala 
    50                  55                  60                  


Leu Gly Phe Glu Asn Ala Thr Gln Ala Leu Gly Arg Ala Ala Phe Gly 
65                  70                  75                  80  


Gln Gly Arg Ala Cys Cys Leu Thr Gly Arg Leu Gln Val Pro Gly Leu 
                85                  90                  95      


Ala Glu Glu Gln Leu Gln Ala Arg Glu Arg Arg Trp Cys Gly Leu His 
            100                 105                 110         


Gln 
    


<210>  7797
<211>  88
<212>  PRT
<213>  Homo Sapiens

<400>  7797

Met Thr Pro Pro Arg Leu Phe Trp Val Trp Leu Leu Val Ala Gly Thr 
1               5                   10                  15      


Gln Gly Val Asn Asp Gly Asp Met Arg Leu Ala Asp Gly Gly Ala Thr 
            20                  25                  30          


Asn Gln Gly Arg Val Glu Ile Phe Tyr Arg Gly Gln Trp Gly Thr Val 
        35                  40                  45              


Cys Asp Asn Leu Trp Asp Leu Thr Asp Ala Ser Val Val Cys Arg Ala 
    50                  55                  60                  


Leu Gly Phe Glu Asn Ala Thr Gln Ala Leu Gly Arg Ala Ala Phe Gly 
65                  70                  75                  80  


Gln Gly Ser Gly Pro Ile Met Leu 
                85              


<210>  7798
<211>  209
<212>  PRT
<213>  Homo Sapiens

<400>  7798

Met Thr Pro Pro Arg Leu Phe Trp Val Trp Leu Leu Val Ala Gly Thr 
1               5                   10                  15      


Gln Gly Val Asn Asp Gly Asp Met Arg Leu Ala Asp Gly Gly Ala Thr 
            20                  25                  30          


Asn Gln Gly Arg Val Glu Ile Phe Tyr Arg Gly Gln Trp Gly Thr Val 
        35                  40                  45              


Cys Asp Asn Leu Trp Asp Leu Thr Asp Ala Ser Val Val Cys Arg Ala 
    50                  55                  60                  


Leu Gly Phe Glu Asn Ala Thr Gln Ala Leu Gly Arg Ala Ala Phe Gly 
65                  70                  75                  80  


Gln Gly Ser Gly Pro Ile Met Leu Asp Glu Val Gln Cys Thr Gly Thr 
                85                  90                  95      


Glu Ala Ser Leu Ala Asp Cys Lys Ser Leu Gly Trp Leu Lys Ser Asn 
            100                 105                 110         


Cys Arg His Glu Arg Asp Ala Gly Val Val Cys Thr Asn Glu Thr Arg 
        115                 120                 125             


Ser Thr His Thr Leu Asp Leu Ser Arg Glu Leu Ser Glu Ala Leu Gly 
    130                 135                 140                 


Gln Ile Phe Asp Ser Gln Arg Gly Cys Asp Leu Ser Ile Ser Val Asn 
145                 150                 155                 160 


Val Gln Gly Glu Asp Ala Leu Gly Phe Cys Gly His Thr Val Ile Leu 
                165                 170                 175     


Thr Ala Asn Leu Glu Ala Gln Ala Leu Trp Lys Glu Pro Gly Ser Asn 
            180                 185                 190         


Val Thr Met Ser Val Asp Ala Glu Cys Val Pro Met Val Arg Asp Leu 
        195                 200                 205             


Leu 
    


<210>  7799
<211>  210
<212>  PRT
<213>  Homo Sapiens

<400>  7799

Met Thr Pro Pro Arg Leu Phe Trp Val Trp Leu Leu Val Ala Gly Thr 
1               5                   10                  15      


Gln Gly Val Asn Asp Gly Asp Met Arg Leu Ala Asp Gly Gly Ala Thr 
            20                  25                  30          


Asn Gln Gly Arg Val Glu Ile Phe Tyr Arg Gly Gln Trp Gly Thr Val 
        35                  40                  45              


Cys Asp Asn Leu Trp Asp Leu Thr Asp Ala Ser Val Val Cys Arg Ala 
    50                  55                  60                  


Leu Gly Phe Glu Asn Ala Thr Gln Ala Leu Gly Arg Ala Ala Phe Gly 
65                  70                  75                  80  


Gln Gly Ser Gly Pro Ile Met Leu Asp Glu Val Gln Cys Thr Gly Thr 
                85                  90                  95      


Glu Ala Ser Leu Ala Asp Cys Lys Ser Leu Gly Trp Leu Lys Ser Asn 
            100                 105                 110         


Cys Arg His Glu Arg Asp Ala Gly Val Val Cys Thr Asn Glu Thr Arg 
        115                 120                 125             


Ser Thr His Thr Leu Asp Leu Ser Arg Glu Leu Ser Glu Ala Leu Gly 
    130                 135                 140                 


Gln Ile Phe Asp Ser Gln Arg Gly Cys Asp Leu Ser Ile Ser Val Asn 
145                 150                 155                 160 


Val Gln Gly Glu Asp Ala Leu Gly Phe Cys Gly His Thr Val Ile Leu 
                165                 170                 175     


Thr Ala Asn Leu Glu Ala Gln Ala Leu Trp Lys Glu Pro Gly Ser Asn 
            180                 185                 190         


Val Thr Met Ser Val Asp Ala Glu Cys Val Pro Met Val Arg Asp Leu 
        195                 200                 205             


Leu Arg 
    210 


<210>  7800
<211>  585
<212>  PRT
<213>  Homo Sapiens

<400>  7800

Met Thr Pro Pro Arg Leu Phe Trp Val Trp Leu Leu Val Ala Gly Thr 
1               5                   10                  15      


Gln Gly Val Asn Asp Gly Asp Met Arg Leu Ala Asp Gly Gly Ala Thr 
            20                  25                  30          


Asn Gln Gly Arg Val Glu Ile Phe Tyr Arg Gly Gln Trp Gly Thr Val 
        35                  40                  45              


Cys Asp Asn Leu Trp Asp Leu Thr Asp Ala Ser Val Val Cys Arg Ala 
    50                  55                  60                  


Leu Gly Phe Glu Asn Ala Thr Gln Ala Leu Gly Arg Ala Ala Phe Gly 
65                  70                  75                  80  


Gln Gly Ser Gly Pro Ile Met Leu Asp Glu Val Gln Cys Thr Gly Thr 
                85                  90                  95      


Glu Ala Ser Leu Ala Asp Cys Lys Ser Leu Gly Trp Leu Lys Ser Asn 
            100                 105                 110         


Cys Arg His Glu Arg Asp Ala Gly Val Val Cys Thr Asn Glu Thr Arg 
        115                 120                 125             


Ser Thr His Thr Leu Asp Leu Ser Arg Glu Leu Ser Glu Ala Leu Gly 
    130                 135                 140                 


Gln Ile Phe Asp Ser Gln Arg Gly Cys Asp Leu Ser Ile Ser Val Asn 
145                 150                 155                 160 


Val Gln Gly Glu Asp Ala Leu Gly Phe Cys Gly His Thr Val Ile Leu 
                165                 170                 175     


Thr Ala Asn Leu Glu Ala Gln Ala Leu Trp Lys Glu Pro Gly Ser Asn 
            180                 185                 190         


Val Thr Met Ser Val Asp Ala Glu Cys Val Pro Met Val Arg Asp Leu 
        195                 200                 205             


Leu Arg Tyr Phe Tyr Ser Arg Arg Ile Asp Ile Thr Leu Ser Ser Val 
    210                 215                 220                 


Lys Cys Phe His Lys Leu Ala Ser Ala Tyr Gly Ala Arg Gln Leu Gln 
225                 230                 235                 240 


Gly Tyr Cys Ala Ser Leu Phe Ala Ile Leu Leu Pro Gln Asp Pro Ser 
                245                 250                 255     


Phe Gln Met Pro Leu Asp Leu Tyr Ala Tyr Ala Val Ala Thr Gly Asp 
            260                 265                 270         


Ala Leu Leu Glu Lys Leu Cys Leu Gln Phe Leu Ala Trp Asn Phe Glu 
        275                 280                 285             


Ala Leu Thr Gln Ala Glu Ala Trp Pro Ser Val Pro Thr Asp Leu Leu 
    290                 295                 300                 


Gln Leu Leu Leu Pro Arg Ser Asp Leu Ala Val Pro Ser Glu Leu Ala 
305                 310                 315                 320 


Leu Leu Lys Ala Val Asp Thr Trp Ser Trp Gly Glu Arg Ala Ser His 
                325                 330                 335     


Glu Glu Val Glu Gly Leu Val Glu Lys Ile Arg Phe Pro Met Met Leu 
            340                 345                 350         


Pro Glu Glu Leu Phe Glu Leu Gln Phe Asn Leu Ser Leu Tyr Trp Ser 
        355                 360                 365             


His Glu Ala Leu Phe Gln Lys Lys Thr Leu Gln Ala Leu Glu Phe His 
    370                 375                 380                 


Thr Val Pro Phe Gln Leu Leu Ala Arg Tyr Lys Gly Leu Asn Leu Thr 
385                 390                 395                 400 


Glu Asp Thr Tyr Lys Pro Arg Ile Tyr Thr Ser Pro Thr Trp Ser Ala 
                405                 410                 415     


Phe Val Thr Asp Ser Ser Trp Ser Ala Arg Lys Ser Gln Leu Val Tyr 
            420                 425                 430         


Gln Ser Arg Arg Gly Pro Leu Val Lys Tyr Ser Ser Asp Tyr Phe Gln 
        435                 440                 445             


Ala Pro Ser Asp Tyr Arg Tyr Tyr Pro Tyr Gln Ser Phe Gln Thr Pro 
    450                 455                 460                 


Gln His Pro Ser Phe Leu Phe Gln Asp Lys Arg Val Ser Trp Ser Leu 
465                 470                 475                 480 


Val Tyr Leu Pro Thr Ile Gln Ser Cys Trp Asn Tyr Gly Phe Ser Cys 
                485                 490                 495     


Ser Ser Asp Glu Leu Pro Val Leu Gly Leu Thr Lys Ser Gly Gly Ser 
            500                 505                 510         


Asp Arg Thr Ile Ala Tyr Glu Asn Lys Ala Leu Met Leu Cys Glu Gly 
        515                 520                 525             


Leu Phe Val Ala Asp Val Thr Asp Phe Glu Gly Trp Lys Ala Ala Ile 
    530                 535                 540                 


Pro Ser Ala Leu Asp Thr Asn Ser Ser Lys Ser Thr Ser Ser Phe Pro 
545                 550                 555                 560 


Cys Pro Ala Gly His Phe Asn Gly Phe Arg Thr Val Ile Arg Pro Phe 
                565                 570                 575     


Tyr Leu Thr Asn Ser Ser Gly Val Asp 
            580                 585 


<210>  7801
<211>  259
<212>  PRT
<213>  Homo Sapiens

<400>  7801

Met Thr Pro Pro Arg Leu Phe Trp Val Trp Leu Leu Val Ala Gly Thr 
1               5                   10                  15      


Gln Gly Val Asn Asp Gly Asp Met Arg Leu Ala Asp Gly Gly Ala Thr 
            20                  25                  30          


Asn Gln Gly Arg Val Glu Ile Phe Tyr Arg Gly Gln Trp Gly Thr Val 
        35                  40                  45              


Cys Asp Asn Leu Trp Asp Leu Thr Asp Ala Ser Val Val Cys Arg Ala 
    50                  55                  60                  


Leu Gly Phe Glu Asn Ala Thr Gln Ala Leu Gly Arg Ala Ala Phe Gly 
65                  70                  75                  80  


Gln Gly Ser Gly Pro Ile Met Leu Asp Glu Val Gln Cys Thr Gly Thr 
                85                  90                  95      


Glu Ala Ser Leu Ala Asp Cys Lys Ser Leu Gly Trp Leu Lys Ser Asn 
            100                 105                 110         


Cys Arg His Glu Arg Asp Ala Gly Val Val Cys Thr Asn Glu Thr Arg 
        115                 120                 125             


Ser Thr His Thr Leu Asp Leu Ser Arg Glu Leu Ser Glu Ala Leu Gly 
    130                 135                 140                 


Gln Ile Phe Asp Ser Gln Arg Gly Cys Asp Leu Ser Ile Ser Val Asn 
145                 150                 155                 160 


Val Gln Gly Glu Asp Ala Leu Gly Phe Cys Gly His Thr Val Ile Leu 
                165                 170                 175     


Thr Ala Asn Leu Glu Ala Gln Ala Leu Trp Lys Glu Pro Gly Ser Asn 
            180                 185                 190         


Val Thr Met Ser Val Asp Ala Glu Cys Val Pro Met Val Arg Asp Leu 
        195                 200                 205             


Leu Arg Tyr Phe Tyr Ser Arg Arg Ile Asp Ile Thr Leu Ser Ser Val 
    210                 215                 220                 


Lys Cys Phe His Lys Leu Ala Ser Ala Tyr Gly Ala Arg Gln Leu Gln 
225                 230                 235                 240 


Gly Tyr Cys Ala Ser Leu Phe Ala Ile Leu Leu Pro Gln Asp Pro Ser 
                245                 250                 255     


Phe Gln Met 
            


<210>  7802
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  7802

Met Thr Pro Pro Arg Leu Phe Trp Val Trp Leu Leu Val Ala Gly Thr 
1               5                   10                  15      


Gln Gly Val Asn Asp Gly Asp Met Arg Leu Ala Asp Gly Gly Ala Thr 
            20                  25                  30          


Asn Gln Gly Arg Val Glu Ile Phe Tyr Arg Gly Gln Trp Gly Thr Val 
        35                  40                  45              


Cys Asp Asn Leu Trp Asp Leu Thr Asp Ala Ser Val Val Cys Arg Ala 
    50                  55                  60                  


Leu Gly Phe Glu Asn Ala Thr Gln Ala Leu Gly Arg Ala Ala Phe Gly 
65                  70                  75                  80  


Gln Gly Ser Gly Pro Ile Met Leu Asp Glu Val Gln Cys Thr Gly Thr 
                85                  90                  95      


Glu Ala Ser Leu Ala Asp Cys Lys Ser Leu Gly Trp Leu Lys Ser Asn 
            100                 105                 110         


Cys Arg His Glu Arg Asp Ala Gly Val Val Cys Thr Asn Gly Ala Phe 
        115                 120                 125             


Gln Ser Glu 
    130     


<210>  7803
<211>  205
<212>  PRT
<213>  Homo Sapiens

<400>  7803

Met Thr Pro Pro Arg Leu Phe Trp Val Trp Leu Leu Val Ala Gly Thr 
1               5                   10                  15      


Gln Gly Val Asn Asp Gly Asp Met Arg Leu Ala Asp Gly Gly Ala Thr 
            20                  25                  30          


Asn Gln Gly Arg Val Glu Ile Phe Tyr Arg Gly Gln Trp Gly Thr Val 
        35                  40                  45              


Cys Asp Asn Leu Trp Asp Leu Thr Asp Ala Ser Val Val Cys Arg Ala 
    50                  55                  60                  


Leu Gly Phe Glu Asn Ala Thr Gln Ala Leu Gly Arg Ala Ala Phe Gly 
65                  70                  75                  80  


Gln Gly Ser Gly Pro Ile Met Leu Asp Glu Val Gln Cys Thr Gly Thr 
                85                  90                  95      


Glu Ala Ser Leu Ala Asp Cys Lys Ser Leu Gly Trp Leu Lys Ser Asn 
            100                 105                 110         


Cys Arg His Glu Arg Asp Ala Gly Val Val Cys Thr Asn Gly Thr Ser 
        115                 120                 125             


Thr Pro Glu Gly Leu Thr Ser Pro Cys Arg Gln Ser Ser Ala Ser Thr 
    130                 135                 140                 


Ser Trp Pro Leu Pro Met Gly Pro Gly Ser Cys Arg Ala Thr Ala Gln 
145                 150                 155                 160 


Ala Ser Leu Pro Ser Ser Ser Pro Arg Thr Pro Arg Ser Arg Cys Pro 
                165                 170                 175     


Trp Thr Cys Met Pro Met Gln Trp Pro Gln Gly Thr Pro Cys Trp Arg 
            180                 185                 190         


Ser Ser Ala Tyr Ser Ser Trp Pro Gly Thr Ser Arg Pro 
        195                 200                 205 


<210>  7804
<211>  52
<212>  PRT
<213>  Homo Sapiens

<400>  7804

Met Glu Ser Glu Arg Ser Lys Arg Met Gly Asn Ala Cys Ile Pro Leu 
1               5                   10                  15      


Lys Arg Ile Ala Tyr Phe Leu Cys Leu Leu Ser Ala Leu Leu Leu Thr 
            20                  25                  30          


Glu Gly Lys Lys Pro Ala Lys Pro Lys Cys Pro Ala Ile Leu Cys Glu 
        35                  40                  45              


Ile Trp Phe Tyr 
    50          


<210>  7805
<211>  72
<212>  PRT
<213>  Homo Sapiens

<400>  7805

Met Glu Ser Glu Arg Ser Lys Arg Met Gly Asn Ala Cys Ile Pro Leu 
1               5                   10                  15      


Lys Arg Ile Ala Tyr Phe Leu Cys Leu Leu Ser Ala Leu Leu Leu Thr 
            20                  25                  30          


Glu Gly Lys Lys Pro Ala Lys Pro Lys Cys Pro Ala Val Cys Thr Cys 
        35                  40                  45              


Thr Lys Asp Asn Ala Leu Cys Glu Asn Ala Arg Ser Ile Pro Arg Thr 
    50                  55                  60                  


Val Pro Pro Asp Val Ile Ser Leu 
65                  70          


<210>  7806
<211>  72
<212>  PRT
<213>  Homo Sapiens

<400>  7806

Met Glu Ser Glu Arg Ser Lys Arg Met Gly Asn Ala Cys Ile Pro Leu 
1               5                   10                  15      


Lys Arg Ile Ala Tyr Phe Leu Cys Leu Leu Ser Ala Leu Leu Leu Thr 
            20                  25                  30          


Glu Gly Lys Lys Pro Ala Lys Pro Lys Cys Pro Ala Val Cys Thr Cys 
        35                  40                  45              


Thr Lys Asp Asn Ala Leu Cys Glu Asn Ala Arg Ser Ile Pro Arg Thr 
    50                  55                  60                  


Val Pro Pro Asp Val Ile Ser Leu 
65                  70          


<210>  7807
<211>  72
<212>  PRT
<213>  Homo Sapiens

<400>  7807

Met Glu Ser Glu Arg Ser Lys Arg Met Gly Asn Ala Cys Ile Pro Leu 
1               5                   10                  15      


Lys Arg Ile Ala Tyr Phe Leu Cys Leu Leu Ser Ala Leu Leu Leu Thr 
            20                  25                  30          


Glu Gly Lys Lys Pro Ala Lys Pro Lys Cys Pro Ala Val Cys Thr Cys 
        35                  40                  45              


Thr Lys Asp Asn Ala Leu Cys Glu Asn Ala Arg Ser Ile Pro Arg Thr 
    50                  55                  60                  


Val Pro Pro Asp Val Ile Ser Leu 
65                  70          


<210>  7808
<211>  72
<212>  PRT
<213>  Homo Sapiens

<400>  7808

Met Glu Ser Glu Arg Ser Lys Arg Met Gly Asn Ala Cys Ile Pro Leu 
1               5                   10                  15      


Lys Arg Ile Ala Tyr Phe Leu Cys Leu Leu Ser Ala Leu Leu Leu Thr 
            20                  25                  30          


Glu Gly Lys Lys Pro Ala Lys Pro Lys Cys Pro Ala Val Cys Thr Cys 
        35                  40                  45              


Thr Lys Asp Asn Ala Leu Cys Glu Asn Ala Arg Ser Ile Pro Arg Thr 
    50                  55                  60                  


Val Pro Pro Asp Val Ile Ser Leu 
65                  70          


<210>  7809
<211>  72
<212>  PRT
<213>  Homo Sapiens

<400>  7809

Met Glu Ser Glu Arg Ser Lys Arg Met Gly Asn Ala Cys Ile Pro Leu 
1               5                   10                  15      


Lys Arg Ile Ala Tyr Phe Leu Cys Leu Leu Ser Ala Leu Leu Leu Thr 
            20                  25                  30          


Glu Gly Lys Lys Pro Ala Lys Pro Lys Cys Pro Ala Val Cys Thr Cys 
        35                  40                  45              


Thr Lys Asp Asn Ala Leu Cys Glu Asn Ala Arg Ser Ile Pro Arg Thr 
    50                  55                  60                  


Val Pro Pro Asp Val Ile Ser Leu 
65                  70          


<210>  7810
<211>  533
<212>  PRT
<213>  Homo Sapiens

<400>  7810

Met Glu Ser Glu Arg Ser Lys Arg Met Gly Asn Ala Cys Ile Pro Leu 
1               5                   10                  15      


Lys Arg Ile Ala Tyr Phe Leu Cys Leu Leu Ser Ala Leu Leu Leu Thr 
            20                  25                  30          


Glu Gly Lys Lys Pro Ala Lys Pro Lys Cys Pro Ala Val Cys Thr Cys 
        35                  40                  45              


Thr Lys Asp Asn Ala Leu Cys Glu Asn Ala Arg Ser Ile Pro Arg Thr 
    50                  55                  60                  


Val Pro Pro Asp Val Ile Ser Leu Leu Phe Thr Ser Asn Ser Phe Asp 
65                  70                  75                  80  


Val Ile Ser Asp Asp Ala Phe Ile Gly Leu Pro His Leu Glu Tyr Leu 
                85                  90                  95      


Phe Ile Glu Asn Asn Asn Ile Lys Ser Ile Ser Arg His Thr Phe Arg 
            100                 105                 110         


Gly Leu Lys Ser Leu Ile His Leu Ser Leu Ala Asn Asn Asn Leu Gln 
        115                 120                 125             


Thr Leu Pro Lys Asp Ile Phe Lys Gly Leu Asp Ser Leu Thr Asn Val 
    130                 135                 140                 


Asp Leu Arg Gly Asn Ser Phe Asn Cys Asp Cys Lys Leu Lys Trp Leu 
145                 150                 155                 160 


Val Glu Trp Leu Gly His Thr Asn Ala Thr Val Glu Asp Ile Tyr Cys 
                165                 170                 175     


Glu Gly Pro Pro Glu Tyr Lys Lys Arg Lys Ile Asn Ser Leu Ser Ser 
            180                 185                 190         


Lys Asp Phe Asp Cys Ile Ile Thr Glu Phe Ala Lys Ser Gln Asp Leu 
        195                 200                 205             


Pro Tyr Gln Ser Leu Ser Ile Asp Thr Phe Ser Tyr Leu Asn Asp Glu 
    210                 215                 220                 


Tyr Val Val Ile Ala Gln Pro Phe Thr Gly Lys Cys Ile Phe Leu Glu 
225                 230                 235                 240 


Trp Asp His Val Glu Lys Thr Phe Arg Asn Tyr Asp Asn Ile Thr Gly 
                245                 250                 255     


Thr Ser Thr Val Val Cys Lys Pro Ile Val Ile Glu Thr Gln Leu Tyr 
            260                 265                 270         


Val Ile Val Ala Gln Leu Phe Gly Gly Ser His Ile Tyr Lys Arg Asp 
        275                 280                 285             


Ser Phe Ala Asn Lys Phe Ile Lys Ile Gln Asp Ile Glu Ile Leu Lys 
    290                 295                 300                 


Ile Arg Lys Pro Asn Asp Ile Glu Thr Phe Lys Ile Glu Asn Asn Trp 
305                 310                 315                 320 


Tyr Phe Val Val Ala Asp Ser Ser Lys Ala Gly Phe Thr Thr Ile Tyr 
                325                 330                 335     


Lys Trp Asn Gly Asn Gly Phe Tyr Ser His Gln Ser Leu His Ala Trp 
            340                 345                 350         


Tyr Arg Asp Thr Asp Val Glu Tyr Leu Glu Ile Val Arg Thr Pro Gln 
        355                 360                 365             


Thr Leu Arg Thr Pro His Leu Ile Leu Ser Ser Ser Ser Gln Arg Pro 
    370                 375                 380                 


Val Ile Tyr Gln Trp Asn Lys Ala Thr Gln Leu Phe Thr Asn Gln Thr 
385                 390                 395                 400 


Asp Ile Pro Asn Met Glu Asp Val Tyr Ala Val Lys His Phe Ser Val 
                405                 410                 415     


Lys Gly Asp Val Tyr Ile Cys Leu Thr Arg Phe Ile Gly Asp Ser Lys 
            420                 425                 430         


Val Met Lys Trp Gly Gly Ser Ser Phe Gln Asp Ile Gln Arg Met Pro 
        435                 440                 445             


Ser Arg Gly Ser Met Val Phe Gln Pro Leu Gln Ile Asn Asn Tyr Gln 
    450                 455                 460                 


Tyr Ala Ile Leu Gly Ser Asp Tyr Ser Phe Thr Gln Val Tyr Asn Trp 
465                 470                 475                 480 


Asp Ala Glu Lys Ala Lys Phe Val Lys Phe Gln Glu Leu Asn Val Gln 
                485                 490                 495     


Ala Pro Arg Ser Phe Thr His Val Ser Ile Asn Lys Arg Asn Phe Leu 
            500                 505                 510         


Phe Ala Ser Ser Phe Lys Gly Asn Thr Gln Ile Tyr Lys His Val Ile 
        515                 520                 525             


Val Asp Leu Ser Ala 
    530             


<210>  7811
<211>  96
<212>  PRT
<213>  Homo Sapiens

<400>  7811

Met Glu Ser Glu Arg Ser Lys Arg Met Gly Asn Ala Cys Ile Pro Leu 
1               5                   10                  15      


Lys Arg Ile Ala Tyr Phe Leu Cys Leu Leu Ser Ala Leu Leu Leu Thr 
            20                  25                  30          


Glu Gly Lys Lys Pro Ala Lys Pro Lys Cys Pro Ala Val Cys Thr Cys 
        35                  40                  45              


Thr Lys Asp Asn Ala Leu Cys Glu Asn Ala Arg Ser Ile Pro Arg Thr 
    50                  55                  60                  


Val Pro Pro Asp Val Ile Ser Leu Ser Phe Val Arg Ser Gly Phe Thr 
65                  70                  75                  80  


Glu Ile Ser Glu Gly Ser Phe Leu Phe Thr Pro Ser Leu Gln Leu Leu 
                85                  90                  95      


<210>  7812
<211>  96
<212>  PRT
<213>  Homo Sapiens

<400>  7812

Met Glu Ser Glu Arg Ser Lys Arg Met Gly Asn Ala Cys Ile Pro Leu 
1               5                   10                  15      


Lys Arg Ile Ala Tyr Phe Leu Cys Leu Leu Ser Ala Leu Leu Leu Thr 
            20                  25                  30          


Glu Gly Lys Lys Pro Ala Lys Pro Lys Cys Pro Ala Val Cys Thr Cys 
        35                  40                  45              


Thr Lys Asp Asn Ala Leu Cys Glu Asn Ala Arg Ser Ile Pro Arg Thr 
    50                  55                  60                  


Val Pro Pro Asp Val Ile Ser Leu Ser Phe Val Arg Ser Gly Phe Thr 
65                  70                  75                  80  


Glu Ile Ser Glu Gly Ser Phe Leu Phe Thr Pro Ser Leu Gln Leu Leu 
                85                  90                  95      


<210>  7813
<211>  236
<212>  PRT
<213>  Homo Sapiens

<400>  7813

Met Glu Ser Glu Arg Ser Lys Arg Met Gly Asn Ala Cys Ile Pro Leu 
1               5                   10                  15      


Lys Arg Ile Ala Tyr Phe Leu Cys Leu Leu Ser Ala Leu Leu Leu Thr 
            20                  25                  30          


Glu Gly Lys Lys Pro Ala Lys Pro Lys Cys Pro Ala Val Cys Thr Cys 
        35                  40                  45              


Thr Lys Asp Asn Ala Leu Cys Glu Asn Ala Arg Ser Ile Pro Arg Thr 
    50                  55                  60                  


Val Pro Pro Asp Val Ile Ser Leu Ser Phe Val Arg Ser Gly Phe Thr 
65                  70                  75                  80  


Glu Ile Ser Glu Gly Ser Phe Leu Phe Thr Pro Ser Leu Gln Leu Leu 
                85                  90                  95      


Leu Phe Thr Ser Asn Ser Phe Asp Val Ile Ser Asp Asp Ala Phe Ile 
            100                 105                 110         


Gly Leu Pro His Leu Glu Tyr Leu Phe Ile Glu Asn Asn Asn Ile Lys 
        115                 120                 125             


Ser Ile Ser Arg His Thr Phe Arg Gly Leu Lys Ser Leu Ile His Leu 
    130                 135                 140                 


Phe Arg Glu Thr Gln Thr Gln Ala Glu Asn Leu His Cys Arg Gly Ala 
145                 150                 155                 160 


Gly Ala Pro Gln Met Ala Val Gly Asp Ala Phe Leu Ala Ala Glu Pro 
                165                 170                 175     


Gly Gly Thr Glu Thr Asn Ala Val Phe Glu Pro Val Trp Ser Ala Leu 
            180                 185                 190         


Glu Arg Arg Leu Ser Ser Gly Phe His Ser His Asn Arg Arg Phe Ser 
        195                 200                 205             


Trp Val Asn Asp Glu Asn Thr Lys Gly Gln Glu Met Val Ile Ile Ser 
    210                 215                 220                 


Val Lys Lys Glu Trp Pro Ser Ala Phe Glu Asn Thr 
225                 230                 235     


<210>  7814
<211>  151
<212>  PRT
<213>  Homo Sapiens

<400>  7814

Met Glu Ser Glu Arg Ser Lys Arg Met Gly Asn Ala Cys Ile Pro Leu 
1               5                   10                  15      


Lys Arg Ile Ala Tyr Phe Leu Cys Leu Leu Ser Ala Leu Leu Leu Thr 
            20                  25                  30          


Glu Gly Lys Lys Pro Ala Lys Pro Lys Cys Pro Ala Val Cys Thr Cys 
        35                  40                  45              


Thr Lys Asp Asn Ala Leu Cys Glu Asn Ala Arg Ser Ile Pro Arg Thr 
    50                  55                  60                  


Val Pro Pro Asp Val Ile Ser Leu Ser Phe Val Arg Ser Gly Phe Thr 
65                  70                  75                  80  


Glu Ile Ser Glu Gly Ser Phe Leu Phe Thr Pro Ser Leu Gln Leu Leu 
                85                  90                  95      


Leu Phe Thr Ser Asn Ser Phe Asp Val Ile Ser Asp Asp Ala Phe Ile 
            100                 105                 110         


Gly Leu Pro His Leu Glu Tyr Leu Phe Ile Glu Asn Asn Asn Ile Lys 
        115                 120                 125             


Ser Ile Ser Arg His Thr Phe Arg Gly Leu Lys Ser Leu Ile His Leu 
    130                 135                 140                 


Arg Asp Gly Val Gly Arg Ile 
145                 150     


<210>  7815
<211>  168
<212>  PRT
<213>  Homo Sapiens

<400>  7815

Met Glu Ser Glu Arg Ser Lys Arg Met Gly Asn Ala Cys Ile Pro Leu 
1               5                   10                  15      


Lys Arg Ile Ala Tyr Phe Leu Cys Leu Leu Ser Ala Leu Leu Leu Thr 
            20                  25                  30          


Glu Gly Lys Lys Pro Ala Lys Pro Lys Cys Pro Ala Val Cys Thr Cys 
        35                  40                  45              


Thr Lys Asp Asn Ala Leu Cys Glu Asn Ala Arg Ser Ile Pro Arg Thr 
    50                  55                  60                  


Val Pro Pro Asp Val Ile Ser Leu Ser Phe Val Arg Ser Gly Phe Thr 
65                  70                  75                  80  


Glu Ile Ser Glu Gly Ser Phe Leu Phe Thr Pro Ser Leu Gln Leu Leu 
                85                  90                  95      


Leu Phe Thr Ser Asn Ser Phe Asp Val Ile Ser Asp Asp Ala Phe Ile 
            100                 105                 110         


Gly Leu Pro His Leu Glu Tyr Leu Phe Ile Glu Asn Asn Asn Ile Lys 
        115                 120                 125             


Ser Ile Ser Arg His Thr Phe Arg Gly Leu Lys Ser Leu Ile His Leu 
    130                 135                 140                 


Ser Leu Ala Asn Asn Asn Leu Gln Thr Leu Pro Lys Asp Ile Phe Lys 
145                 150                 155                 160 


Gly Leu Asp Ser Leu Thr Asn Val 
                165             


<210>  7816
<211>  168
<212>  PRT
<213>  Homo Sapiens

<400>  7816

Met Glu Ser Glu Arg Ser Lys Arg Met Gly Asn Ala Cys Ile Pro Leu 
1               5                   10                  15      


Lys Arg Ile Ala Tyr Phe Leu Cys Leu Leu Ser Ala Leu Leu Leu Thr 
            20                  25                  30          


Glu Gly Lys Lys Pro Ala Lys Pro Lys Cys Pro Ala Val Cys Thr Cys 
        35                  40                  45              


Thr Lys Asp Asn Ala Leu Cys Glu Asn Ala Arg Ser Ile Pro Arg Thr 
    50                  55                  60                  


Val Pro Pro Asp Val Ile Ser Leu Ser Phe Val Arg Ser Gly Phe Thr 
65                  70                  75                  80  


Glu Ile Ser Glu Gly Ser Phe Leu Phe Thr Pro Ser Leu Gln Leu Leu 
                85                  90                  95      


Leu Phe Thr Ser Asn Ser Phe Asp Val Ile Ser Asp Asp Ala Phe Ile 
            100                 105                 110         


Gly Leu Pro His Leu Glu Tyr Leu Phe Ile Glu Asn Asn Asn Ile Lys 
        115                 120                 125             


Ser Ile Ser Arg His Thr Phe Arg Gly Leu Lys Ser Leu Ile His Leu 
    130                 135                 140                 


Ser Leu Ala Asn Asn Asn Leu Gln Thr Leu Pro Lys Asp Ile Phe Lys 
145                 150                 155                 160 


Gly Leu Asp Ser Leu Thr Asn Val 
                165             


<210>  7817
<211>  557
<212>  PRT
<213>  Homo Sapiens

<400>  7817

Met Glu Ser Glu Arg Ser Lys Arg Met Gly Asn Ala Cys Ile Pro Leu 
1               5                   10                  15      


Lys Arg Ile Ala Tyr Phe Leu Cys Leu Leu Ser Ala Leu Leu Leu Thr 
            20                  25                  30          


Glu Gly Lys Lys Pro Ala Lys Pro Lys Cys Pro Ala Val Cys Thr Cys 
        35                  40                  45              


Thr Lys Asp Asn Ala Leu Cys Glu Asn Ala Arg Ser Ile Pro Arg Thr 
    50                  55                  60                  


Val Pro Pro Asp Val Ile Ser Leu Ser Phe Val Arg Ser Gly Phe Thr 
65                  70                  75                  80  


Glu Ile Ser Glu Gly Ser Phe Leu Phe Thr Pro Ser Leu Gln Leu Leu 
                85                  90                  95      


Leu Phe Thr Ser Asn Ser Phe Asp Val Ile Ser Asp Asp Ala Phe Ile 
            100                 105                 110         


Gly Leu Pro His Leu Glu Tyr Leu Phe Ile Glu Asn Asn Asn Ile Lys 
        115                 120                 125             


Ser Ile Ser Arg His Thr Phe Arg Gly Leu Lys Ser Leu Ile His Leu 
    130                 135                 140                 


Ser Leu Ala Asn Asn Asn Leu Gln Thr Leu Pro Lys Asp Ile Phe Lys 
145                 150                 155                 160 


Gly Leu Asp Ser Leu Thr Asn Val Asp Leu Arg Gly Asn Ser Phe Asn 
                165                 170                 175     


Cys Asp Cys Lys Leu Lys Trp Leu Val Glu Trp Leu Gly His Thr Asn 
            180                 185                 190         


Ala Thr Val Glu Asp Ile Tyr Cys Glu Gly Pro Pro Glu Tyr Lys Lys 
        195                 200                 205             


Arg Lys Ile Asn Ser Leu Ser Ser Lys Asp Phe Asp Cys Ile Ile Thr 
    210                 215                 220                 


Glu Phe Ala Lys Ser Gln Asp Leu Pro Tyr Gln Ser Leu Ser Ile Asp 
225                 230                 235                 240 


Thr Phe Ser Tyr Leu Asn Asp Glu Tyr Val Val Ile Ala Gln Pro Phe 
                245                 250                 255     


Thr Gly Lys Cys Ile Phe Leu Glu Trp Asp His Val Glu Lys Thr Phe 
            260                 265                 270         


Arg Asn Tyr Asp Asn Ile Thr Gly Thr Ser Thr Val Val Cys Lys Pro 
        275                 280                 285             


Ile Val Ile Glu Thr Gln Leu Tyr Val Ile Val Ala Gln Leu Phe Gly 
    290                 295                 300                 


Gly Ser His Ile Tyr Lys Arg Asp Ser Phe Ala Asn Lys Phe Ile Lys 
305                 310                 315                 320 


Ile Gln Asp Ile Glu Ile Leu Lys Ile Arg Lys Pro Asn Asp Ile Glu 
                325                 330                 335     


Thr Phe Lys Ile Glu Asn Asn Trp Tyr Phe Val Val Ala Asp Ser Ser 
            340                 345                 350         


Lys Ala Gly Phe Thr Thr Ile Tyr Lys Trp Asn Gly Asn Gly Phe Tyr 
        355                 360                 365             


Ser His Gln Ser Leu His Ala Trp Tyr Arg Asp Thr Asp Val Glu Tyr 
    370                 375                 380                 


Leu Glu Ile Val Arg Thr Pro Gln Thr Leu Arg Thr Pro His Leu Ile 
385                 390                 395                 400 


Leu Ser Ser Ser Ser Gln Arg Pro Val Ile Tyr Gln Trp Asn Lys Ala 
                405                 410                 415     


Thr Gln Leu Phe Thr Asn Gln Thr Asp Ile Pro Asn Met Glu Asp Val 
            420                 425                 430         


Tyr Ala Val Lys His Phe Ser Val Lys Gly Asp Val Tyr Ile Cys Leu 
        435                 440                 445             


Thr Arg Phe Ile Gly Asp Ser Lys Val Met Lys Trp Gly Gly Ser Ser 
    450                 455                 460                 


Phe Gln Asp Ile Gln Arg Met Pro Ser Arg Gly Ser Met Val Phe Gln 
465                 470                 475                 480 


Pro Leu Gln Ile Asn Asn Tyr Gln Tyr Ala Ile Leu Gly Ser Asp Tyr 
                485                 490                 495     


Ser Phe Thr Gln Val Tyr Asn Trp Asp Ala Glu Lys Ala Lys Phe Val 
            500                 505                 510         


Lys Phe Gln Glu Leu Asn Val Gln Ala Pro Arg Ser Phe Thr His Val 
        515                 520                 525             


Ser Ile Asn Lys Arg Asn Phe Leu Phe Ala Ser Ser Phe Lys Gly Asn 
    530                 535                 540                 


Thr Gln Ile Tyr Lys His Val Ile Val Asp Leu Ser Ala 
545                 550                 555         


<210>  7818
<211>  291
<212>  PRT
<213>  Homo Sapiens

<400>  7818

Met Glu Ser Glu Arg Ser Lys Arg Met Gly Asn Ala Cys Ile Pro Leu 
1               5                   10                  15      


Lys Arg Ile Ala Tyr Phe Leu Cys Leu Leu Ser Ala Leu Leu Leu Thr 
            20                  25                  30          


Glu Gly Lys Lys Pro Ala Lys Pro Lys Cys Pro Ala Val Cys Thr Cys 
        35                  40                  45              


Thr Lys Asp Asn Ala Leu Cys Glu Asn Ala Arg Ser Ile Pro Arg Thr 
    50                  55                  60                  


Val Pro Pro Asp Val Ile Ser Leu Ser Phe Val Arg Ser Gly Phe Thr 
65                  70                  75                  80  


Glu Ile Ser Glu Gly Ser Phe Leu Phe Thr Pro Ser Leu Gln Leu Leu 
                85                  90                  95      


Leu Phe Thr Ser Asn Ser Phe Asp Val Ile Ser Asp Asp Ala Phe Ile 
            100                 105                 110         


Gly Leu Pro His Leu Glu Tyr Leu Phe Ile Glu Asn Asn Asn Ile Lys 
        115                 120                 125             


Ser Ile Ser Arg His Thr Phe Arg Gly Leu Lys Ser Leu Ile His Leu 
    130                 135                 140                 


Ser Leu Ala Asn Asn Asn Leu Gln Thr Leu Pro Lys Asp Ile Phe Lys 
145                 150                 155                 160 


Gly Leu Asp Ser Leu Thr Asn Val Asp Leu Arg Gly Asn Ser Phe Asn 
                165                 170                 175     


Cys Asp Cys Lys Leu Lys Trp Leu Val Glu Trp Leu Gly His Thr Asn 
            180                 185                 190         


Ala Thr Val Glu Asp Ile Tyr Cys Glu Gly Pro Pro Glu Tyr Lys Lys 
        195                 200                 205             


Arg Lys Ile Asn Ser Leu Ser Ser Lys Asp Phe Asp Cys Ile Ile Thr 
    210                 215                 220                 


Glu Phe Ala Lys Ser Gln Asp Leu Pro Tyr Gln Ser Leu Ser Ile Asp 
225                 230                 235                 240 


Thr Phe Ser Tyr Leu Asn Asp Glu Tyr Val Val Ile Ala Gln Pro Phe 
                245                 250                 255     


Thr Gly Lys Cys Ile Phe Leu Glu Trp Asp His Val Glu Lys Thr Phe 
            260                 265                 270         


Arg Asn Tyr Asp Asn Ile Thr Val Leu Arg Glu Ile His Arg Phe Thr 
        275                 280                 285             


Asn Met Ser 
    290     


<210>  7819
<211>  287
<212>  PRT
<213>  Homo Sapiens

<400>  7819

Met Glu Ser Glu Arg Ser Lys Arg Met Gly Asn Ala Cys Ile Pro Leu 
1               5                   10                  15      


Lys Arg Ile Ala Tyr Phe Leu Cys Leu Leu Ser Ala Leu Leu Leu Thr 
            20                  25                  30          


Glu Gly Lys Lys Pro Ala Lys Pro Lys Cys Pro Ala Val Cys Thr Cys 
        35                  40                  45              


Thr Lys Asp Asn Ala Leu Cys Glu Asn Ala Arg Ser Ile Pro Arg Thr 
    50                  55                  60                  


Val Pro Pro Asp Val Ile Ser Leu Ser Phe Val Arg Ser Gly Phe Thr 
65                  70                  75                  80  


Glu Ile Ser Glu Gly Ser Phe Leu Phe Thr Pro Ser Leu Gln Leu Leu 
                85                  90                  95      


Leu Phe Thr Ser Asn Ser Phe Asp Val Ile Ser Asp Asp Ala Phe Ile 
            100                 105                 110         


Gly Leu Pro His Leu Glu Tyr Leu Phe Ile Glu Asn Asn Asn Ile Lys 
        115                 120                 125             


Ser Ile Ser Arg His Thr Phe Arg Gly Leu Lys Ser Leu Ile His Leu 
    130                 135                 140                 


Ser Leu Ala Asn Asn Asn Leu Gln Thr Leu Pro Lys Asp Ile Phe Lys 
145                 150                 155                 160 


Gly Leu Asp Ser Leu Thr Asn Val Asp Leu Arg Gly Asn Ser Phe Asn 
                165                 170                 175     


Cys Asp Cys Lys Leu Lys Trp Leu Val Glu Trp Leu Gly His Thr Asn 
            180                 185                 190         


Ala Thr Val Glu Asp Ile Tyr Cys Glu Gly Pro Pro Glu Tyr Lys Lys 
        195                 200                 205             


Arg Lys Ile Asn Ser Leu Ser Ser Lys Asp Phe Asp Cys Ile Ile Thr 
    210                 215                 220                 


Glu Phe Ala Lys Ser Gln Asp Leu Pro Tyr Gln Ser Leu Ser Ile Asp 
225                 230                 235                 240 


Thr Phe Ser Tyr Leu Asn Asp Glu Tyr Val Val Ile Ala Gln Pro Phe 
                245                 250                 255     


Thr Gly Lys Cys Ile Phe Leu Glu Trp Asp His Val Glu Lys Thr Phe 
            260                 265                 270         


Arg Asn Tyr Asp Asn Ile Thr Gly Gln Ser Cys Trp Cys Pro Gln 
        275                 280                 285         


<210>  7820
<211>  281
<212>  PRT
<213>  Homo Sapiens

<400>  7820

Met Glu Ser Glu Arg Ser Lys Arg Met Gly Asn Ala Cys Ile Pro Leu 
1               5                   10                  15      


Lys Arg Ile Ala Tyr Phe Leu Cys Leu Leu Ser Ala Leu Leu Leu Thr 
            20                  25                  30          


Glu Gly Lys Lys Pro Ala Lys Pro Lys Cys Pro Ala Val Cys Thr Cys 
        35                  40                  45              


Thr Lys Asp Asn Ala Leu Cys Glu Asn Ala Arg Ser Ile Pro Arg Thr 
    50                  55                  60                  


Val Pro Pro Asp Val Ile Ser Leu Ser Phe Val Arg Ser Gly Phe Thr 
65                  70                  75                  80  


Glu Ile Ser Glu Gly Ser Phe Leu Phe Thr Pro Ser Leu Gln Leu Leu 
                85                  90                  95      


Leu Phe Thr Ser Asn Ser Phe Asp Val Ile Ser Asp Asp Ala Phe Ile 
            100                 105                 110         


Gly Leu Pro His Leu Glu Tyr Leu Phe Ile Glu Asn Asn Asn Ile Lys 
        115                 120                 125             


Ser Ile Ser Arg His Thr Phe Arg Gly Leu Lys Ser Leu Ile His Leu 
    130                 135                 140                 


Ser Leu Ala Asn Asn Asn Leu Gln Thr Leu Pro Lys Asp Ile Phe Lys 
145                 150                 155                 160 


Gly Leu Asp Ser Leu Thr Asn Val Asp Leu Arg Gly Asn Ser Phe Asn 
                165                 170                 175     


Cys Asp Cys Lys Leu Lys Trp Leu Val Glu Trp Leu Gly His Thr Asn 
            180                 185                 190         


Ala Thr Val Glu Asp Ile Tyr Cys Glu Gly Pro Pro Glu Tyr Lys Lys 
        195                 200                 205             


Arg Lys Ile Asn Ser Leu Ser Ser Lys Asp Phe Asp Cys Ile Ile Thr 
    210                 215                 220                 


Glu Phe Ala Lys Ser Gln Asp Leu Pro Tyr Gln Ser Leu Ser Ile Asp 
225                 230                 235                 240 


Thr Phe Ser Tyr Leu Asn Asp Glu Tyr Val Val Ile Ala Gln Pro Phe 
                245                 250                 255     


Thr Gly Lys Cys Ile Phe Leu Glu Trp Asp His Val Glu Lys Thr Phe 
            260                 265                 270         


Arg Asn Tyr Asp Asn Ile Thr Gly Ser 
        275                 280     


<210>  7821
<211>  509
<212>  PRT
<213>  Homo Sapiens

<400>  7821

Met Glu Ser Glu Arg Ser Lys Arg Met Gly Asn Ala Cys Ile Pro Leu 
1               5                   10                  15      


Lys Arg Ile Ala Tyr Phe Leu Cys Leu Leu Ser Ala Leu Leu Leu Thr 
            20                  25                  30          


Glu Gly Lys Lys Pro Ala Lys Pro Lys Cys Pro Ala Val Cys Thr Cys 
        35                  40                  45              


Thr Lys Asp Asn Ala Leu Cys Glu Asn Ala Arg Ser Ile Pro Arg Thr 
    50                  55                  60                  


Val Pro Pro Asp Val Ile Ser Leu Ser Phe Val Arg Ser Gly Phe Thr 
65                  70                  75                  80  


Glu Ile Ser Glu Gly Ser Phe Leu Phe Thr Pro Ser Leu Gln Leu Leu 
                85                  90                  95      


Ser Leu Ala Asn Asn Asn Leu Gln Thr Leu Pro Lys Asp Ile Phe Lys 
            100                 105                 110         


Gly Leu Asp Ser Leu Thr Asn Val Asp Leu Arg Gly Asn Ser Phe Asn 
        115                 120                 125             


Cys Asp Cys Lys Leu Lys Trp Leu Val Glu Trp Leu Gly His Thr Asn 
    130                 135                 140                 


Ala Thr Val Glu Asp Ile Tyr Cys Glu Gly Pro Pro Glu Tyr Lys Lys 
145                 150                 155                 160 


Arg Lys Ile Asn Ser Leu Ser Ser Lys Asp Phe Asp Cys Ile Ile Thr 
                165                 170                 175     


Glu Phe Ala Lys Ser Gln Asp Leu Pro Tyr Gln Ser Leu Ser Ile Asp 
            180                 185                 190         


Thr Phe Ser Tyr Leu Asn Asp Glu Tyr Val Val Ile Ala Gln Pro Phe 
        195                 200                 205             


Thr Gly Lys Cys Ile Phe Leu Glu Trp Asp His Val Glu Lys Thr Phe 
    210                 215                 220                 


Arg Asn Tyr Asp Asn Ile Thr Gly Thr Ser Thr Val Val Cys Lys Pro 
225                 230                 235                 240 


Ile Val Ile Glu Thr Gln Leu Tyr Val Ile Val Ala Gln Leu Phe Gly 
                245                 250                 255     


Gly Ser His Ile Tyr Lys Arg Asp Ser Phe Ala Asn Lys Phe Ile Lys 
            260                 265                 270         


Ile Gln Asp Ile Glu Ile Leu Lys Ile Arg Lys Pro Asn Asp Ile Glu 
        275                 280                 285             


Thr Phe Lys Ile Glu Asn Asn Trp Tyr Phe Val Val Ala Asp Ser Ser 
    290                 295                 300                 


Lys Ala Gly Phe Thr Thr Ile Tyr Lys Trp Asn Gly Asn Gly Phe Tyr 
305                 310                 315                 320 


Ser His Gln Ser Leu His Ala Trp Tyr Arg Asp Thr Asp Val Glu Tyr 
                325                 330                 335     


Leu Glu Ile Val Arg Thr Pro Gln Thr Leu Arg Thr Pro His Leu Ile 
            340                 345                 350         


Leu Ser Ser Ser Ser Gln Arg Pro Val Ile Tyr Gln Trp Asn Lys Ala 
        355                 360                 365             


Thr Gln Leu Phe Thr Asn Gln Thr Asp Ile Pro Asn Met Glu Asp Val 
    370                 375                 380                 


Tyr Ala Val Lys His Phe Ser Val Lys Gly Asp Val Tyr Ile Cys Leu 
385                 390                 395                 400 


Thr Arg Phe Ile Gly Asp Ser Lys Val Met Lys Trp Gly Gly Ser Ser 
                405                 410                 415     


Phe Gln Asp Ile Gln Arg Met Pro Ser Arg Gly Ser Met Val Phe Gln 
            420                 425                 430         


Pro Leu Gln Ile Asn Asn Tyr Gln Tyr Ala Ile Leu Gly Ser Asp Tyr 
        435                 440                 445             


Ser Phe Thr Gln Val Tyr Asn Trp Asp Ala Glu Lys Ala Lys Phe Val 
    450                 455                 460                 


Lys Phe Gln Glu Leu Asn Val Gln Ala Pro Arg Ser Phe Thr His Val 
465                 470                 475                 480 


Ser Ile Asn Lys Arg Asn Phe Leu Phe Ala Ser Ser Phe Lys Gly Asn 
                485                 490                 495     


Thr Gln Ile Tyr Lys His Val Ile Val Asp Leu Ser Ala 
            500                 505                 


<210>  7822
<211>  100
<212>  PRT
<213>  Homo Sapiens

<400>  7822

Met Lys Trp Gly Gly Ser Ser Phe Gln Asp Ile Gln Arg Met Pro Ser 
1               5                   10                  15      


Arg Gly Ser Met Val Phe Gln Pro Leu Gln Ile Asn Asn Tyr Gln Tyr 
            20                  25                  30          


Ala Ile Leu Gly Ser Asp Tyr Ser Phe Thr Gln Val Tyr Asn Trp Asp 
        35                  40                  45              


Ala Glu Lys Ala Lys Phe Val Lys Phe Gln Glu Leu Asn Val Gln Ala 
    50                  55                  60                  


Pro Arg Ser Phe Thr His Val Ser Ile Asn Lys Arg Asn Phe Leu Phe 
65                  70                  75                  80  


Ala Ser Ser Phe Lys Gly Asn Thr Gln Ile Tyr Lys His Val Ile Val 
                85                  90                  95      


Asp Leu Ser Ala 
            100 


<210>  7823
<211>  545
<212>  PRT
<213>  Homo Sapiens

<400>  7823

Met Ala Leu Arg Arg Gly Gly Cys Gly Ala Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Gly Ala Ala Cys Leu Ile Pro Arg Ser Ala Gln Val Arg Arg 
            20                  25                  30          


Leu Ala Arg Cys Pro Ala Thr Cys Ser Cys Thr Lys Glu Ser Ile Ile 
        35                  40                  45              


Cys Val Gly Ser Ser Trp Val Pro Arg Ile Val Pro Gly Asp Ile Ser 
    50                  55                  60                  


Ser Leu Ser Leu Val Asn Gly Thr Phe Ser Glu Ile Lys Asp Arg Met 
65                  70                  75                  80  


Phe Ser His Leu Pro Ser Leu Gln Leu Leu Leu Leu Asn Ser Asn Ser 
                85                  90                  95      


Phe Thr Ile Ile Arg Asp Asp Ala Phe Ala Gly Leu Phe His Leu Glu 
            100                 105                 110         


Tyr Leu Phe Ile Glu Gly Asn Lys Ile Glu Thr Ile Ser Arg Asn Ala 
        115                 120                 125             


Phe Arg Gly Leu Arg Asp Leu Thr His Leu Ser Leu Ala Asn Asn His 
    130                 135                 140                 


Ile Lys Ala Leu Pro Arg Asp Val Phe Ser Asp Leu Asp Ser Leu Ile 
145                 150                 155                 160 


Glu Leu Asp Leu Arg Gly Asn Lys Phe Glu Cys Asp Cys Lys Ala Lys 
                165                 170                 175     


Trp Leu Tyr Leu Trp Leu Lys Met Thr Asn Ser Thr Val Ser Asp Val 
            180                 185                 190         


Leu Cys Ile Gly Pro Pro Glu Tyr Gln Glu Lys Lys Leu Asn Asp Val 
        195                 200                 205             


Thr Ser Phe Asp Tyr Glu Cys Thr Thr Thr Asp Phe Val Val His Gln 
    210                 215                 220                 


Thr Leu Pro Tyr Gln Ser Val Ser Val Asp Thr Phe Asn Ser Lys Asn 
225                 230                 235                 240 


Asp Val Tyr Val Ala Ile Ala Gln Pro Ser Met Glu Asn Cys Met Val 
                245                 250                 255     


Leu Glu Trp Asp His Ile Glu Met Asn Phe Arg Ser Tyr Asp Asn Ile 
            260                 265                 270         


Thr Gly Gln Ser Ile Val Gly Cys Lys Ala Ile Leu Ile Asp Asp Gln 
        275                 280                 285             


Val Phe Val Val Val Ala Gln Leu Phe Gly Gly Ser His Ile Tyr Lys 
    290                 295                 300                 


Tyr Asp Glu Ser Trp Thr Lys Phe Val Lys Phe Gln Asp Ile Glu Val 
305                 310                 315                 320 


Ser Arg Ile Ser Lys Pro Asn Asp Ile Glu Leu Phe Gln Ile Asp Asp 
                325                 330                 335     


Glu Thr Phe Phe Val Ile Ala Asp Ser Ser Lys Ala Gly Leu Ser Thr 
            340                 345                 350         


Val Tyr Lys Trp Asn Ser Lys Gly Phe Tyr Ser Tyr Gln Ser Leu His 
        355                 360                 365             


Glu Trp Phe Arg Asp Thr Asp Ala Glu Phe Val Asp Ile Asp Gly Lys 
    370                 375                 380                 


Ser His Leu Ile Leu Ser Ser Arg Ser Gln Val Pro Ile Ile Leu Gln 
385                 390                 395                 400 


Trp Asn Lys Ser Ser Lys Lys Phe Val Pro His Gly Asp Ile Pro Asn 
                405                 410                 415     


Met Glu Asp Val Leu Ala Val Lys Ser Phe Arg Met Gln Asn Thr Leu 
            420                 425                 430         


Tyr Leu Ser Leu Thr Arg Phe Ile Gly Asp Ser Arg Val Met Arg Trp 
        435                 440                 445             


Asn Ser Lys Gln Phe Val Glu Ile Gln Ala Leu Pro Ser Arg Gly Ala 
    450                 455                 460                 


Met Thr Leu Gln Pro Phe Ser Phe Lys Asp Asn His Tyr Leu Ala Leu 
465                 470                 475                 480 


Gly Ser Asp Tyr Thr Phe Ser Gln Ile Tyr Gln Trp Asp Lys Glu Lys 
                485                 490                 495     


Gln Leu Phe Lys Lys Phe Lys Glu Ile Tyr Val Gln Ala Pro Arg Ser 
            500                 505                 510         


Phe Thr Ala Val Ser Thr Asp Arg Arg Asp Phe Phe Phe Ala Ser Ser 
        515                 520                 525             


Phe Lys Gly Lys Thr Lys Ile Phe Glu His Ile Ile Val Asp Leu Ser 
    530                 535                 540                 


Leu 
545 


<210>  7824
<211>  256
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7824

Xaa Leu Gly Leu Leu Leu Leu Leu Leu Gly Ala Ala Cys Leu Ile Pro 
1               5                   10                  15      


Arg Ser Ala Gln Val Arg Arg Leu Ala Arg Cys Pro Ala Thr Cys Ser 
            20                  25                  30          


Cys Thr Lys Glu Ser Ile Ile Cys Val Gly Ser Ser Trp Val Pro Arg 
        35                  40                  45              


Ile Val Pro Gly Asp Ile Ser Ser Leu Ser Leu Val Asn Gly Thr Phe 
    50                  55                  60                  


Ser Glu Ile Lys Asp Arg Met Phe Ser His Leu Pro Ser Leu Gln Leu 
65                  70                  75                  80  


Leu Leu Leu Asn Ser Asn Ser Phe Thr Ile Ile Arg Asp Asp Ala Phe 
                85                  90                  95      


Ala Gly Leu Phe His Leu Glu Tyr Leu Phe Ile Glu Gly Asn Lys Ile 
            100                 105                 110         


Glu Thr Ile Ser Arg Asn Ala Phe Arg Gly Leu Arg Asp Leu Thr His 
        115                 120                 125             


Leu Ser Leu Ala Asn Asn His Ile Lys Ala Leu Pro Arg Asp Val Phe 
    130                 135                 140                 


Ser Asp Leu Asp Ser Leu Ile Glu Leu Asp Leu Arg Gly Asn Lys Phe 
145                 150                 155                 160 


Glu Cys Asp Cys Lys Ala Lys Trp Leu Tyr Leu Trp Leu Lys Met Thr 
                165                 170                 175     


Asn Ser Thr Val Ser Asp Val Leu Cys Ile Gly Pro Pro Glu Tyr Gln 
            180                 185                 190         


Glu Lys Lys Leu Asn Asp Val Thr Ser Phe Asp Tyr Glu Cys Thr Thr 
        195                 200                 205             


Thr Asp Lys Gln Glu Glu Ile Cys Glu Gly Lys Ile Gln Asn Leu Asn 
    210                 215                 220                 


Ala Arg Val Val Met Asn Cys Ser Arg Pro Ser Ser Ala Phe Arg Lys 
225                 230                 235                 240 


His Thr Gly Asn Gly Arg Val Ala Phe Phe Leu Pro His Gly Val Arg 
                245                 250                 255     


<210>  7825
<211>  134
<212>  PRT
<213>  Homo Sapiens

<400>  7825

Met Ala Gly Leu Arg Ala Arg Gly Gly Pro Gly Pro Gly Leu Leu Ala 
1               5                   10                  15      


Leu Ser Ala Leu Gly Phe Cys Leu Met Leu Gln Val Ser Ala Lys Arg 
            20                  25                  30          


Pro Pro Lys Thr Pro Pro Cys Pro Pro Ser Cys Ser Cys Thr Arg Asp 
        35                  40                  45              


Thr Ala Phe Cys Val Asp Ser Lys Ala Val Pro Arg Asn Leu Pro Ser 
    50                  55                  60                  


Glu Val Ile Ser Leu Thr Ala Leu Ala Asp Pro Thr Val Leu Thr Arg 
65                  70                  75                  80  


Val Ser Pro Gln Asp Pro Gly Glu Cys Arg Leu Leu Arg Asp Pro Gly 
                85                  90                  95      


Trp Ser Val Leu Pro Pro Pro Ala Ala Ala Val Leu Val Thr Gln Leu 
            100                 105                 110         


Gln Gln Val Tyr Thr Asp Trp Arg Gln Arg Leu His Arg Thr Val Ala 
        115                 120                 125             


Pro Ala Val Ser Leu His 
    130                 


<210>  7826
<211>  548
<212>  PRT
<213>  Homo Sapiens

<400>  7826

Met Ala Gly Leu Arg Ala Arg Gly Gly Pro Gly Pro Gly Leu Leu Ala 
1               5                   10                  15      


Leu Ser Ala Leu Gly Phe Cys Leu Met Leu Gln Val Ser Ala Lys Arg 
            20                  25                  30          


Pro Pro Lys Thr Pro Pro Cys Pro Pro Ser Cys Ser Cys Thr Arg Asp 
        35                  40                  45              


Thr Ala Phe Cys Val Asp Ser Lys Ala Val Pro Arg Asn Leu Pro Ser 
    50                  55                  60                  


Glu Val Ile Ser Leu Thr Leu Val Asn Ala Ala Phe Ser Glu Ile Gln 
65                  70                  75                  80  


Asp Gly Ala Phe Ser His Leu Pro Leu Leu Gln Phe Leu Leu Leu Asn 
                85                  90                  95      


Ser Asn Lys Phe Thr Leu Ile Gly Asp Asn Ala Phe Thr Gly Leu Ser 
            100                 105                 110         


His Leu Gln Tyr Leu Phe Ile Glu Asn Asn Asp Ile Trp Ala Leu Ser 
        115                 120                 125             


Lys Phe Thr Phe Arg Gly Leu Lys Ser Leu Thr His Leu Ser Leu Ala 
    130                 135                 140                 


Asn Asn Asn Leu Gln Thr Leu Pro Arg Asp Ile Phe Arg Pro Leu Asp 
145                 150                 155                 160 


Ile Leu Asn Asp Leu Asp Leu Arg Gly Asn Ser Leu Asn Cys Asp Cys 
                165                 170                 175     


Lys Val Lys Trp Leu Val Glu Trp Leu Ala His Thr Asn Thr Thr Val 
            180                 185                 190         


Ala Pro Ile Tyr Cys Ala Ser Pro Pro Arg Phe Gln Glu His Lys Val 
        195                 200                 205             


Gln Asp Leu Pro Leu Arg Glu Phe Asp Cys Ile Thr Thr Asp Phe Val 
    210                 215                 220                 


Leu Tyr Gln Thr Leu Ala Phe Pro Ala Val Ser Ala Glu Pro Phe Leu 
225                 230                 235                 240 


Tyr Ser Ser Asp Leu Tyr Leu Ala Leu Ala Gln Pro Gly Val Ser Ala 
                245                 250                 255     


Cys Thr Ile Leu Lys Trp Asp Tyr Val Glu Arg Gln Leu Arg Asp Tyr 
            260                 265                 270         


Asp Arg Ile Pro Ala Pro Ser Ala Val His Cys Lys Pro Met Val Val 
        275                 280                 285             


Asp Ser Gln Leu Tyr Val Val Val Ala Gln Leu Phe Gly Gly Ser Tyr 
    290                 295                 300                 


Ile Tyr His Trp Asp Pro Asn Thr Thr Arg Phe Thr Arg Leu Gln Asp 
305                 310                 315                 320 


Ile Asp Pro Gln Arg Val Arg Lys Pro Asn Asp Leu Glu Ala Phe Arg 
                325                 330                 335     


Ile Asp Gly Asp Trp Tyr Phe Ala Val Ala Asp Ser Ser Lys Ala Gly 
            340                 345                 350         


Ala Thr Ser Leu Tyr Arg Trp His Gln Asn Gly Phe Tyr Ser His Gln 
        355                 360                 365             


Ala Leu His Pro Trp His Arg Asp Thr Asp Leu Glu Phe Val Asp Gly 
    370                 375                 380                 


Glu Gly Lys Pro Arg Leu Ile Val Ser Ser Ser Ser Gln Ala Pro Val 
385                 390                 395                 400 


Ile Tyr Gln Trp Ser Arg Thr Gln Lys Gln Phe Val Ala Gln Gly Glu 
                405                 410                 415     


Val Thr Gln Val Pro Asp Ala Gln Ala Val Lys His Phe Arg Ala Gly 
            420                 425                 430         


Arg Asp Ser Tyr Leu Cys Leu Ser Arg Tyr Ile Gly Asp Ser Lys Ile 
        435                 440                 445             


Leu Arg Trp Glu Gly Thr Arg Phe Ser Glu Val Gln Ala Leu Pro Ser 
    450                 455                 460                 


Arg Gly Ser Leu Ala Leu Gln Pro Phe Leu Val Gly Gly Arg Arg Tyr 
465                 470                 475                 480 


Leu Ala Leu Gly Ser Asp Phe Ser Phe Thr Gln Ile Tyr Gln Trp Asp 
                485                 490                 495     


Glu Gly Arg Gln Lys Phe Val Arg Phe Gln Glu Leu Ala Val Gln Ala 
            500                 505                 510         


Pro Arg Ala Phe Cys Tyr Met Pro Ala Gly Asp Ala Gln Leu Leu Leu 
        515                 520                 525             


Ala Pro Ser Phe Lys Gly Gln Thr Leu Val Tyr Arg His Ile Val Val 
    530                 535                 540                 


Asp Leu Ser Ala 
545             


<210>  7827
<211>  524
<212>  PRT
<213>  Homo Sapiens

<400>  7827

Met Ala Gly Leu Arg Ala Arg Gly Gly Pro Gly Pro Gly Leu Leu Ala 
1               5                   10                  15      


Leu Ser Ala Leu Gly Phe Cys Leu Met Leu Gln Val Ser Ala Lys Arg 
            20                  25                  30          


Pro Pro Lys Thr Pro Pro Cys Pro Pro Ser Cys Ser Cys Thr Arg Asp 
        35                  40                  45              


Thr Ala Phe Cys Val Asp Ser Lys Ala Val Pro Arg Asn Leu Pro Ser 
    50                  55                  60                  


Glu Val Ile Ser Leu Thr Leu Val Asn Ala Ala Phe Ser Glu Ile Gln 
65                  70                  75                  80  


Asp Gly Ala Phe Ser His Leu Pro Leu Leu Gln Phe Leu Leu Leu Asn 
                85                  90                  95      


Ser Asn Lys Phe Thr Leu Ile Gly Asp Asn Ala Phe Thr Gly Leu Ser 
            100                 105                 110         


His Leu Gln Tyr Leu Ser Leu Ala Asn Asn Asn Leu Gln Thr Leu Pro 
        115                 120                 125             


Arg Asp Ile Phe Arg Pro Leu Asp Ile Leu Asn Asp Leu Asp Leu Arg 
    130                 135                 140                 


Gly Asn Ser Leu Asn Cys Asp Cys Lys Val Lys Trp Leu Val Glu Trp 
145                 150                 155                 160 


Leu Ala His Thr Asn Thr Thr Val Ala Pro Ile Tyr Cys Ala Ser Pro 
                165                 170                 175     


Pro Arg Phe Gln Glu His Lys Val Gln Asp Leu Pro Leu Arg Glu Phe 
            180                 185                 190         


Asp Cys Ile Thr Thr Asp Phe Val Leu Tyr Gln Thr Leu Ala Phe Pro 
        195                 200                 205             


Ala Val Ser Ala Glu Pro Phe Leu Tyr Ser Ser Asp Leu Tyr Leu Ala 
    210                 215                 220                 


Leu Ala Gln Pro Gly Val Ser Ala Cys Thr Ile Leu Lys Trp Asp Tyr 
225                 230                 235                 240 


Val Glu Arg Gln Leu Arg Asp Tyr Asp Arg Ile Pro Ala Pro Ser Ala 
                245                 250                 255     


Val His Cys Lys Pro Met Val Val Asp Ser Gln Leu Tyr Val Val Val 
            260                 265                 270         


Ala Gln Leu Phe Gly Gly Ser Tyr Ile Tyr His Trp Asp Pro Asn Thr 
        275                 280                 285             


Thr Arg Phe Thr Arg Leu Gln Asp Ile Asp Pro Gln Arg Val Arg Lys 
    290                 295                 300                 


Pro Asn Asp Leu Glu Ala Phe Arg Ile Asp Gly Asp Trp Tyr Phe Ala 
305                 310                 315                 320 


Val Ala Asp Ser Ser Lys Ala Gly Ala Thr Ser Leu Tyr Arg Trp His 
                325                 330                 335     


Gln Asn Gly Phe Tyr Ser His Gln Ala Leu His Pro Trp His Arg Asp 
            340                 345                 350         


Thr Asp Leu Glu Phe Val Asp Gly Glu Gly Lys Pro Arg Leu Ile Val 
        355                 360                 365             


Ser Ser Ser Ser Gln Ala Pro Val Ile Tyr Gln Trp Ser Arg Thr Gln 
    370                 375                 380                 


Lys Gln Phe Val Ala Gln Gly Glu Val Thr Gln Val Pro Asp Ala Gln 
385                 390                 395                 400 


Ala Val Lys His Phe Arg Ala Gly Arg Asp Ser Tyr Leu Cys Leu Ser 
                405                 410                 415     


Arg Tyr Ile Gly Asp Ser Lys Ile Leu Arg Trp Glu Gly Thr Arg Phe 
            420                 425                 430         


Ser Glu Val Gln Ala Leu Pro Ser Arg Gly Ser Leu Ala Leu Gln Pro 
        435                 440                 445             


Phe Leu Val Gly Gly Arg Arg Tyr Leu Ala Leu Gly Ser Asp Phe Ser 
    450                 455                 460                 


Phe Thr Gln Ile Tyr Gln Trp Asp Glu Gly Arg Gln Lys Phe Val Arg 
465                 470                 475                 480 


Phe Gln Glu Leu Ala Val Gln Ala Pro Arg Ala Phe Cys Tyr Met Pro 
                485                 490                 495     


Ala Gly Asp Ala Gln Leu Leu Leu Ala Pro Ser Phe Lys Gly Gln Thr 
            500                 505                 510         


Leu Val Tyr Arg His Ile Val Val Asp Leu Ser Ala 
        515                 520                 


<210>  7828
<211>  198
<212>  PRT
<213>  Homo Sapiens

<400>  7828

Met Cys Pro Cys Arg Asp Arg Thr Leu Val Asn Ala Ala Phe Ser Glu 
1               5                   10                  15      


Ile Gln Asp Gly Ala Phe Ser His Leu Pro Leu Leu Gln Phe Leu Leu 
            20                  25                  30          


Leu Asn Ser Asn Lys Phe Thr Leu Ile Gly Asp Asn Ala Phe Thr Gly 
        35                  40                  45              


Leu Ser His Leu Gln Tyr Leu Phe Ile Glu Asn Asn Asp Ile Trp Ala 
    50                  55                  60                  


Leu Ser Lys Phe Thr Phe Arg Gly Leu Lys Ser Leu Thr His Leu Ser 
65                  70                  75                  80  


Leu Ala Asn Asn Asn Leu Gln Thr Leu Pro Arg Asp Ile Phe Arg Pro 
                85                  90                  95      


Leu Asp Ile Leu Asn Asp Leu Asp Leu Arg Gly Asn Ser Leu Asn Cys 
            100                 105                 110         


Asp Cys Lys Val Lys Trp Leu Val Glu Trp Leu Ala His Thr Asn Thr 
        115                 120                 125             


Thr Val Ala Pro Ile Tyr Cys Ala Ser Pro Pro Arg Phe Gln Glu His 
    130                 135                 140                 


Lys Val Gln Asp Leu Pro Leu Arg Glu Phe Asp Cys Ile Thr Thr Asp 
145                 150                 155                 160 


Phe Val Leu Tyr Gln Thr Leu Ala Phe Pro Ala Val Ser Ala Glu Pro 
                165                 170                 175     


Phe Leu Tyr Ser Ser Asp Leu Tyr Leu Ala Leu Ala Gln Pro Gly Val 
            180                 185                 190         


Ser Ala Cys Thr Ile Leu 
        195             


<210>  7829
<211>  537
<212>  PRT
<213>  Homo Sapiens

<400>  7829

Met Gly Gly Ala Gly Ile Leu Leu Leu Leu Leu Ala Gly Ala Gly Val 
1               5                   10                  15      


Val Val Ala Trp Arg Pro Pro Lys Gly Lys Cys Pro Leu Arg Cys Ser 
            20                  25                  30          


Cys Ser Lys Asp Ser Ala Leu Cys Glu Gly Ser Pro Asp Leu Pro Val 
        35                  40                  45              


Ser Phe Ser Pro Thr Leu Leu Ser Leu Ser Leu Val Arg Thr Gly Val 
    50                  55                  60                  


Thr Gln Leu Lys Ala Gly Ser Phe Leu Arg Ile Pro Ser Leu His Leu 
65                  70                  75                  80  


Leu Leu Phe Thr Ser Asn Ser Phe Ser Val Ile Glu Asp Asp Ala Phe 
                85                  90                  95      


Ala Gly Leu Ser His Leu Gln Tyr Leu Phe Ile Glu Asp Asn Glu Ile 
            100                 105                 110         


Gly Ser Ile Ser Lys Asn Ala Leu Arg Gly Leu Arg Ser Leu Thr His 
        115                 120                 125             


Leu Ser Leu Ala Asn Asn His Leu Glu Thr Leu Pro Arg Phe Leu Phe 
    130                 135                 140                 


Arg Gly Leu Asp Thr Leu Thr His Val Asp Leu Arg Gly Asn Pro Phe 
145                 150                 155                 160 


Gln Cys Asp Cys Arg Val Leu Trp Leu Leu Gln Trp Met Pro Thr Val 
                165                 170                 175     


Asn Ala Ser Val Gly Thr Gly Ala Cys Ala Gly Pro Ala Ser Leu Ser 
            180                 185                 190         


His Met Gln Leu His His Leu Asp Pro Lys Thr Phe Lys Cys Arg Ala 
        195                 200                 205             


Ile Glu Leu Ser Trp Phe Gln Thr Val Gly Glu Ser Ala Leu Ser Val 
    210                 215                 220                 


Glu Pro Phe Ser Tyr Gln Gly Glu Pro His Ile Val Leu Ala Gln Pro 
225                 230                 235                 240 


Phe Ala Gly Arg Cys Leu Ile Leu Ser Trp Asp Tyr Ser Leu Gln Arg 
                245                 250                 255     


Phe Arg Pro Glu Glu Glu Leu Pro Ala Ala Ser Val Val Ser Cys Lys 
            260                 265                 270         


Pro Leu Val Leu Gly Pro Ser Leu Phe Val Leu Ala Ala Arg Leu Trp 
        275                 280                 285             


Gly Gly Ser Gln Leu Trp Ala Arg Pro Ser Pro Gly Leu Arg Leu Ala 
    290                 295                 300                 


Pro Thr Gln Thr Leu Ala Pro Arg Arg Leu Leu Arg Pro Asn Asp Ala 
305                 310                 315                 320 


Glu Leu Leu Trp Leu Glu Gly Gln Pro Cys Phe Val Val Ala Asp Ala 
                325                 330                 335     


Ser Lys Ala Gly Ser Thr Thr Leu Leu Cys Arg Asp Gly Pro Gly Phe 
            340                 345                 350         


Tyr Pro His Gln Ser Leu His Ala Trp His Arg Asp Thr Asp Ala Glu 
        355                 360                 365             


Ala Leu Glu Leu Asp Gly Arg Pro His Leu Leu Leu Ala Ser Ala Ser 
    370                 375                 380                 


Gln Arg Pro Val Leu Phe His Trp Thr Gly Gly Arg Phe Glu Arg Arg 
385                 390                 395                 400 


Thr Asp Ile Pro Glu Ala Glu Asp Val Tyr Ala Thr Arg His Phe Gln 
                405                 410                 415     


Ala Gly Gly Asp Val Phe Leu Cys Leu Thr Arg Tyr Ile Gly Asp Ser 
            420                 425                 430         


Met Val Met Arg Trp Asp Gly Ser Met Phe Arg Leu Leu Gln Gln Leu 
        435                 440                 445             


Pro Ser Arg Gly Ala His Val Phe Gln Pro Leu Leu Ile Ala Arg Asp 
    450                 455                 460                 


Gln Leu Ala Ile Leu Gly Ser Asp Phe Ala Phe Ser Gln Val Leu Arg 
465                 470                 475                 480 


Leu Glu Pro Asp Lys Gly Leu Leu Glu Pro Leu Gln Glu Leu Gly Pro 
                485                 490                 495     


Pro Ala Leu Val Ala Pro Arg Ala Phe Ala His Ile Thr Met Ala Gly 
            500                 505                 510         


Arg Arg Phe Leu Phe Ala Ala Cys Phe Lys Gly Pro Thr Gln Ile Tyr 
        515                 520                 525             


Gln His His Glu Ile Asp Leu Ser Ala 
    530                 535         


<210>  7830
<211>  494
<212>  PRT
<213>  Homo Sapiens

<400>  7830

Met Gly Gly Ala Gly Ile Leu Leu Leu Leu Leu Ala Gly Ala Gly Val 
1               5                   10                  15      


Val Val Ala Trp Arg Pro Pro Lys Gly Lys Cys Pro Leu Arg Cys Ser 
            20                  25                  30          


Cys Ser Lys Asp Ser Ala Leu Cys Glu Gly Ser Pro Asp Leu Pro Val 
        35                  40                  45              


Ser Phe Ser Pro Thr Leu Leu Ser Leu Ser Leu Val Arg Thr Gly Val 
    50                  55                  60                  


Thr Gln Leu Lys Ala Gly Ser Phe Leu Arg Ile Pro Ser Leu His Leu 
65                  70                  75                  80  


Leu Leu Phe Thr Ser Asn Ser Phe Ser Val Ile Glu Asp Asp Ala Phe 
                85                  90                  95      


Ala Gly Leu Ser His Leu Gln Tyr Leu Phe Ile Glu Asp Asn Glu Ile 
            100                 105                 110         


Gly Ser Ile Ser Lys Asn Ala Leu Arg Gly Leu Arg Ser Leu Thr His 
        115                 120                 125             


Leu Ser Leu Ala Asn Asn His Leu Glu Thr Leu Pro Arg Phe Leu Phe 
    130                 135                 140                 


Arg Gly Leu Asp Thr Leu Thr His Val Asp Leu Arg Gly Asn Pro Phe 
145                 150                 155                 160 


Gln Cys Asp Cys Arg Val Leu Trp Leu Leu Gln Trp Met Pro Thr Val 
                165                 170                 175     


Asn Ala Ser Val Gly Thr Gly Ala Cys Ala Gly Pro Ala Ser Leu Ser 
            180                 185                 190         


His Met Gln Leu His His Leu Asp Pro Lys Thr Phe Lys Cys Arg Ala 
        195                 200                 205             


Ile Glu Leu Ser Trp Phe Gln Thr Val Gly Glu Ser Ala Leu Ser Val 
    210                 215                 220                 


Glu Pro Phe Ser Tyr Gln Gly Glu Pro His Ile Val Leu Ala Gln Pro 
225                 230                 235                 240 


Phe Ala Gly Arg Cys Leu Ile Leu Ser Trp Asp Tyr Ser Leu Gln Arg 
                245                 250                 255     


Phe Arg Pro Glu Glu Glu Leu Pro Gly Glu Pro Pro Pro Arg Pro Ser 
            260                 265                 270         


Ala Cys Pro Ala Ala Cys Leu Ala Gly Leu Thr Cys Leu Pro Thr Ser 
        275                 280                 285             


Pro Gln Arg Pro Pro Trp Cys Pro Ala Ser His Trp Cys Trp Ala Arg 
    290                 295                 300                 


Ala Ser Ser Cys Trp Leu Pro Ala Cys Gly Gly Ala His Ser Cys Gly 
305                 310                 315                 320 


Pro Gly Pro Val Pro Ala Cys Ala Trp Pro Gln Arg Arg Pro Trp Pro 
                325                 330                 335     


Arg Gly Gly Cys Cys Gly Pro Met Thr Pro Ser Ser Cys Gly Trp Lys 
            340                 345                 350         


Gly Asn Pro Ala Ser Trp Trp Pro Met Pro Pro Arg Arg Ala Ala Pro 
        355                 360                 365             


Arg Cys Cys Ala Ala Thr Gly Pro Ala Phe Thr Arg Thr Arg Ala Cys 
    370                 375                 380                 


Thr Pro Gly Thr Gly Thr Arg Thr Leu Arg Pro Trp Ser Trp Thr Ala 
385                 390                 395                 400 


Gly Pro Thr Cys Cys Trp Pro Arg Leu Pro Ser Gly Pro Cys Ser Ser 
                405                 410                 415     


Thr Gly Pro Val Ala Ala Ser Arg Asp Ala Gln Thr Ser Pro Arg Pro 
            420                 425                 430         


Arg Met Ser Met Pro His Ala Thr Ser Arg Leu Val Gly Thr Cys Ser 
        435                 440                 445             


Cys Ala Ser His Ala Thr Leu Gly Thr Pro Trp Ser Cys Ala Gly Thr 
    450                 455                 460                 


Ala Pro Cys Phe Val Cys Cys Ser Asn Phe Pro Arg Ala Val Pro Thr 
465                 470                 475                 480 


Ser Ser Ser His Cys Ser Ser Pro Gly Thr Ser Trp Pro Ser 
                485                 490                 


<210>  7831
<211>  261
<212>  PRT
<213>  Homo Sapiens

<400>  7831

Met Gly Gly Ala Gly Ile Leu Leu Leu Leu Leu Ala Gly Ala Gly Val 
1               5                   10                  15      


Val Val Ala Trp Arg Pro Pro Lys Gly Lys Cys Pro Leu Arg Cys Ser 
            20                  25                  30          


Cys Ser Lys Asp Ser Ala Leu Cys Glu Gly Ser Pro Asp Leu Pro Val 
        35                  40                  45              


Ser Phe Ser Pro Thr Leu Leu Ser Leu Ser Leu Val Arg Thr Gly Val 
    50                  55                  60                  


Thr Gln Leu Lys Ala Gly Ser Phe Leu Arg Ile Pro Ser Leu His Leu 
65                  70                  75                  80  


Leu Leu Phe Thr Ser Asn Ser Phe Ser Val Ile Glu Asp Asp Ala Phe 
                85                  90                  95      


Ala Gly Leu Ser His Leu Gln Tyr Leu Phe Ile Glu Asp Asn Glu Ile 
            100                 105                 110         


Gly Ser Ile Ser Lys Asn Ala Leu Arg Gly Leu Arg Ser Leu Thr His 
        115                 120                 125             


Leu Ser Leu Ala Asn Asn His Leu Glu Thr Leu Pro Arg Phe Leu Phe 
    130                 135                 140                 


Arg Gly Leu Asp Thr Leu Thr His Val Asp Leu Arg Gly Asn Pro Phe 
145                 150                 155                 160 


Gln Cys Asp Cys Arg Val Leu Trp Leu Leu Gln Trp Met Pro Thr Val 
                165                 170                 175     


Asn Ala Ser Val Gly Thr Gly Ala Cys Ala Gly Pro Ala Ser Leu Ser 
            180                 185                 190         


His Met Gln Leu His His Leu Asp Pro Lys Thr Phe Lys Cys Arg Ala 
        195                 200                 205             


Ile Gly Gly Gly Leu Ser Arg Trp Gly Gly Arg Arg Glu Ile Trp Gly 
    210                 215                 220                 


Lys Gly Cys Gln Gly Gln Glu Ala Arg Leu Thr Pro Cys Pro Ala Ile 
225                 230                 235                 240 


Ser Arg Ser Gly Lys Thr Leu Ser Lys Gln His Cys Leu Pro Glu Pro 
                245                 250                 255     


Gln Phe Ser His Leu 
            260     


<210>  7832
<211>  378
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7832

Xaa Val Ile Glu Asp Asp Ala Phe Ala Gly Leu Ser His Leu Gln Tyr 
1               5                   10                  15      


Leu Phe Ile Glu Asp Asn Glu Ile Gly Ser Ile Ser Lys Asn Ala Leu 
            20                  25                  30          


Arg Gly Leu Arg Ser Leu Thr His Leu Ser Leu Ala Asn Asn His Leu 
        35                  40                  45              


Glu Thr Leu Pro Arg Phe Leu Phe Arg Gly Leu Asp Thr Leu Thr His 
    50                  55                  60                  


Val Asp Leu Arg Gly Asn Pro Phe Gln Cys Asp Cys Arg Val Leu Trp 
65                  70                  75                  80  


Leu Leu Gln Trp Met Pro Thr Val Asn Ala Ser Val Gly Thr Gly Ala 
                85                  90                  95      


Cys Ala Gly Pro Ala Ser Leu Ser His Met Gln Leu His His Leu Asp 
            100                 105                 110         


Pro Lys Thr Phe Lys Cys Arg Ala Ile Glu Leu Ser Trp Phe Gln Thr 
        115                 120                 125             


Val Gly Glu Ser Ala Leu Ser Val Glu Pro Phe Ser Tyr Gln Gly Glu 
    130                 135                 140                 


Pro His Ile Val Leu Ala Gln Pro Phe Ala Gly Arg Cys Leu Ile Leu 
145                 150                 155                 160 


Ser Trp Asp Tyr Ser Leu Gln Arg Phe Arg Pro Glu Glu Glu Leu Pro 
                165                 170                 175     


Ala Ala Ser Val Val Ser Cys Lys Pro Leu Val Leu Gly Pro Ser Leu 
            180                 185                 190         


Phe Val Leu Ala Ala Arg Leu Trp Gly Gly Ser Gln Leu Trp Ala Arg 
        195                 200                 205             


Pro Ser Pro Gly Leu Arg Leu Ala Pro Thr Gln Thr Leu Ala Pro Arg 
    210                 215                 220                 


Arg Leu Leu Arg Pro Asn Asp Ala Glu Leu Leu Trp Leu Glu Gly Gln 
225                 230                 235                 240 


Pro Cys Phe Val Val Ala Asp Ala Ser Lys Ala Gly Ser Thr Thr Leu 
                245                 250                 255     


Leu Cys Arg Asp Gly Pro Gly Phe Tyr Pro His Gln Ser Leu His Ala 
            260                 265                 270         


Trp His Arg Asp Thr Asp Ala Glu Ala Leu Glu Leu Asp Gly Arg Pro 
        275                 280                 285             


His Leu Leu Leu Ala Ser Ala Ser Gln Arg Pro Val Leu Phe His Trp 
    290                 295                 300                 


Thr Gly Gly Arg Phe Glu Arg Arg Thr Asp Ile Pro Glu Ala Glu Asp 
305                 310                 315                 320 


Val Tyr Ala Thr Arg His Phe Gln Ala Gly Gly Asp Val Phe Leu Cys 
                325                 330                 335     


Leu Thr Arg Tyr Ile Gly Asp Ser Met Val Arg Leu Gly Leu Gly Ala 
            340                 345                 350         


Gly Gly Trp Leu Phe Ser Thr Asp Pro Ile Leu His Thr Lys Pro Leu 
        355                 360                 365             


Asn Ser Asp Leu Pro Ser His Ala Asp Leu 
    370                 375             


<210>  7833
<211>  19
<212>  PRT
<213>  Homo Sapiens

<400>  7833

Met Val Trp Lys Val Ala Val Phe Leu Ser Val Ala Leu Gly Ile Gly 
1               5                   10                  15      


Ala Val Pro 
            


<210>  7834
<211>  57
<212>  PRT
<213>  Homo Sapiens

<400>  7834

Met Val Trp Lys Val Ala Val Phe Leu Ser Val Ala Leu Gly Ile Gly 
1               5                   10                  15      


Ala Val Pro Ile Asp Asp Pro Glu Asp Gly Gly Lys His Trp Val Val 
            20                  25                  30          


Ile Val Ala Gly Ser Asn Gly Trp Tyr Asn Tyr Arg His Gln Ala Asp 
        35                  40                  45              


Ala Cys His Ala Tyr Gln Ile Ile His 
    50                  55          


<210>  7835
<211>  58
<212>  PRT
<213>  Homo Sapiens

<400>  7835

Met Val Trp Lys Val Ala Val Phe Leu Ser Val Ala Leu Gly Ile Gly 
1               5                   10                  15      


Ala Val Pro Ile Asp Asp Pro Glu Asp Gly Gly Lys His Trp Val Val 
            20                  25                  30          


Ile Val Ala Gly Ser Asn Gly Trp Tyr Asn Tyr Arg His Gln Ala Asp 
        35                  40                  45              


Ala Cys His Ala Tyr Gln Ile Ile His Arg 
    50                  55              


<210>  7836
<211>  135
<212>  PRT
<213>  Homo Sapiens

<400>  7836

Met Val Trp Lys Val Ala Val Phe Leu Ser Val Ala Leu Gly Ile Gly 
1               5                   10                  15      


Ala Val Pro Ile Asp Asp Pro Glu Asp Gly Gly Lys His Trp Val Val 
            20                  25                  30          


Ile Val Ala Gly Ser Asn Gly Trp Tyr Asn Tyr Arg His Gln Ala Asp 
        35                  40                  45              


Ala Cys His Ala Tyr Gln Ile Ile His Arg Asn Gly Ile Pro Asp Glu 
    50                  55                  60                  


Gln Ile Val Val Met Ile Asn Pro Thr Pro Gly Ile Val Ile Asn Arg 
65                  70                  75                  80  


Pro Asn Gly Thr Asp Val Tyr Gln Gly Val Pro Lys Asp Tyr Thr Gly 
                85                  90                  95      


Glu Asp Val Thr Pro Gln Asn Phe Leu Ala Val Leu Arg Gly Asp Ala 
            100                 105                 110         


Glu Ala Val Lys Gly Ile Gly Ser Gly Lys Val Leu Lys Ser Gly Pro 
        115                 120                 125             


Gln Asp His Val Phe Ile Tyr 
    130                 135 


<210>  7837
<211>  78
<212>  PRT
<213>  Homo Sapiens

<400>  7837

Met Val Trp Lys Val Ala Val Phe Leu Ser Val Ala Leu Gly Ile Gly 
1               5                   10                  15      


Ala Val Pro Ile Asp Asp Pro Glu Asp Gly Gly Lys His Trp Val Val 
            20                  25                  30          


Ile Val Ala Gly Ser Asn Gly Trp Tyr Asn Tyr Arg His Gln Ala Asp 
        35                  40                  45              


Ala Cys His Ala Tyr Gln Ile Ile His Arg Asn Gly Ile Pro Asp Glu 
    50                  55                  60                  


Gln Ile Val Val Met Met Tyr Asp Asp Ile Ala Tyr Ser Glu 
65                  70                  75              


<210>  7838
<211>  78
<212>  PRT
<213>  Homo Sapiens

<400>  7838

Met Val Trp Lys Val Ala Val Phe Leu Ser Val Ala Leu Gly Ile Gly 
1               5                   10                  15      


Ala Val Pro Ile Asp Asp Pro Glu Asp Gly Gly Lys His Trp Val Val 
            20                  25                  30          


Ile Val Ala Gly Ser Asn Gly Trp Tyr Asn Tyr Arg His Gln Ala Asp 
        35                  40                  45              


Ala Cys His Ala Tyr Gln Ile Ile His Arg Asn Gly Ile Pro Asp Glu 
    50                  55                  60                  


Gln Ile Val Val Met Met Tyr Asp Asp Ile Ala Tyr Ser Glu 
65                  70                  75              


<210>  7839
<211>  223
<212>  PRT
<213>  Homo Sapiens

<400>  7839

Met Val Trp Lys Val Ala Val Phe Leu Ser Val Ala Leu Gly Ile Gly 
1               5                   10                  15      


Ala Val Pro Ile Asp Asp Pro Glu Asp Gly Gly Lys His Trp Val Val 
            20                  25                  30          


Ile Val Ala Gly Ser Asn Gly Trp Tyr Asn Tyr Arg His Gln Ala Asp 
        35                  40                  45              


Ala Cys His Ala Tyr Gln Ile Ile His Arg Asn Gly Ile Pro Asp Glu 
    50                  55                  60                  


Gln Ile Val Val Met Met Tyr Asp Asp Ile Ala Tyr Ser Glu Asp Asn 
65                  70                  75                  80  


Pro Thr Pro Gly Ile Val Ile Asn Arg Pro Asn Gly Thr Asp Val Tyr 
                85                  90                  95      


Gln Gly Val Pro Lys Asp Tyr Thr Gly Glu Asp Val Thr Pro Gln Asn 
            100                 105                 110         


Phe Leu Ala Val Leu Arg Gly Asp Ala Glu Ala Val Lys Gly Ile Gly 
        115                 120                 125             


Ser Gly Lys Val Leu Lys Ser Gly Pro Gln Asp His Val Phe Ile Tyr 
    130                 135                 140                 


Phe Thr Asp His Gly Ser Thr Gly Ile Leu Val Phe Pro Asn Glu Asp 
145                 150                 155                 160 


Leu His Val Lys Asp Leu Asn Glu Thr Ile His Tyr Met Tyr Lys His 
                165                 170                 175     


Lys Met Tyr Arg Lys Met Val Phe Tyr Ile Glu Ala Cys Glu Ser Gly 
            180                 185                 190         


Ser Met Met Asn His Leu Pro Asp Asn Ile Asn Gly Arg Trp Leu Gly 
        195                 200                 205             


Arg Arg Pro Arg Pro Gly Leu Ala Ser Arg Leu Leu Arg His Arg 
    210                 215                 220             


<210>  7840
<211>  433
<212>  PRT
<213>  Homo Sapiens

<400>  7840

Met Val Trp Lys Val Ala Val Phe Leu Ser Val Ala Leu Gly Ile Gly 
1               5                   10                  15      


Ala Val Pro Ile Asp Asp Pro Glu Asp Gly Gly Lys His Trp Val Val 
            20                  25                  30          


Ile Val Ala Gly Ser Asn Gly Trp Tyr Asn Tyr Arg His Gln Ala Asp 
        35                  40                  45              


Ala Cys His Ala Tyr Gln Ile Ile His Arg Asn Gly Ile Pro Asp Glu 
    50                  55                  60                  


Gln Ile Val Val Met Met Tyr Asp Asp Ile Ala Tyr Ser Glu Asp Asn 
65                  70                  75                  80  


Pro Thr Pro Gly Ile Val Ile Asn Arg Pro Asn Gly Thr Asp Val Tyr 
                85                  90                  95      


Gln Gly Val Pro Lys Asp Tyr Thr Gly Glu Asp Val Thr Pro Gln Asn 
            100                 105                 110         


Phe Leu Ala Val Leu Arg Gly Asp Ala Glu Ala Val Lys Gly Ile Gly 
        115                 120                 125             


Ser Gly Lys Val Leu Lys Ser Gly Pro Gln Asp His Val Phe Ile Tyr 
    130                 135                 140                 


Phe Thr Asp His Gly Ser Thr Gly Ile Leu Val Phe Pro Asn Glu Asp 
145                 150                 155                 160 


Leu His Val Lys Asp Leu Asn Glu Thr Ile His Tyr Met Tyr Lys His 
                165                 170                 175     


Lys Met Tyr Arg Lys Met Val Phe Tyr Ile Glu Ala Cys Glu Ser Gly 
            180                 185                 190         


Ser Met Met Asn His Leu Pro Asp Asn Ile Asn Val Tyr Ala Thr Thr 
        195                 200                 205             


Ala Ala Asn Pro Arg Glu Ser Ser Tyr Ala Cys Tyr Tyr Asp Glu Lys 
    210                 215                 220                 


Arg Ser Thr Tyr Leu Gly Asp Trp Tyr Ser Val Asn Trp Met Glu Asp 
225                 230                 235                 240 


Ser Asp Val Glu Asp Leu Thr Lys Glu Thr Leu His Lys Gln Tyr His 
                245                 250                 255     


Leu Val Lys Ser His Thr Asn Thr Ser His Val Met Gln Tyr Gly Asn 
            260                 265                 270         


Lys Thr Ile Ser Thr Met Lys Val Met Gln Phe Gln Gly Met Lys Arg 
        275                 280                 285             


Lys Ala Ser Ser Pro Val Pro Leu Pro Pro Val Thr His Leu Asp Leu 
    290                 295                 300                 


Thr Pro Ser Pro Asp Val Pro Leu Thr Ile Met Lys Arg Lys Leu Met 
305                 310                 315                 320 


Asn Thr Asn Asp Leu Glu Glu Ser Arg Gln Leu Thr Glu Glu Ile Gln 
                325                 330                 335     


Arg His Leu Asp Ala Arg His Leu Ile Glu Lys Ser Val Arg Lys Ile 
            340                 345                 350         


Val Ser Leu Leu Ala Ala Ser Glu Ala Glu Val Glu Gln Leu Leu Ser 
        355                 360                 365             


Glu Arg Ala Pro Leu Thr Gly His Ser Cys Tyr Pro Glu Ala Leu Leu 
    370                 375                 380                 


His Phe Arg Thr His Cys Phe Asn Trp His Ser Pro Thr Tyr Glu Tyr 
385                 390                 395                 400 


Ala Leu Arg His Leu Tyr Val Leu Val Asn Leu Cys Glu Lys Pro Tyr 
                405                 410                 415     


Pro Leu His Arg Ile Lys Leu Ser Met Asp His Val Cys Leu Gly His 
            420                 425                 430         


Tyr 
    


<210>  7841
<211>  433
<212>  PRT
<213>  Homo Sapiens

<400>  7841

Met Val Trp Lys Val Ala Val Phe Leu Ser Val Ala Leu Gly Ile Gly 
1               5                   10                  15      


Ala Val Pro Ile Asp Asp Pro Glu Asp Gly Gly Lys His Trp Val Val 
            20                  25                  30          


Ile Val Ala Gly Ser Asn Gly Trp Tyr Asn Tyr Arg His Gln Ala Asp 
        35                  40                  45              


Ala Cys His Ala Tyr Gln Ile Ile His Arg Asn Gly Ile Pro Asp Glu 
    50                  55                  60                  


Gln Ile Val Val Met Met Tyr Asp Asp Ile Ala Tyr Ser Glu Asp Asn 
65                  70                  75                  80  


Pro Thr Pro Gly Ile Val Ile Asn Arg Pro Asn Gly Thr Asp Val Tyr 
                85                  90                  95      


Gln Gly Val Pro Lys Asp Tyr Thr Gly Glu Asp Val Thr Pro Gln Asn 
            100                 105                 110         


Phe Leu Ala Val Leu Arg Gly Asp Ala Glu Ala Val Lys Gly Ile Gly 
        115                 120                 125             


Ser Gly Lys Val Leu Lys Ser Gly Pro Gln Asp His Val Phe Ile Tyr 
    130                 135                 140                 


Phe Thr Asp His Gly Ser Thr Gly Ile Leu Val Phe Pro Asn Glu Asp 
145                 150                 155                 160 


Leu His Val Lys Asp Leu Asn Glu Thr Ile His Tyr Met Tyr Lys His 
                165                 170                 175     


Lys Met Tyr Arg Lys Met Val Phe Tyr Ile Glu Ala Cys Glu Ser Gly 
            180                 185                 190         


Ser Met Met Asn His Leu Pro Asp Asn Ile Asn Val Tyr Ala Thr Thr 
        195                 200                 205             


Ala Ala Asn Pro Arg Glu Ser Ser Tyr Ala Cys Tyr Tyr Asp Glu Lys 
    210                 215                 220                 


Arg Ser Thr Tyr Leu Gly Asp Trp Tyr Ser Val Asn Trp Met Glu Asp 
225                 230                 235                 240 


Ser Asp Val Glu Asp Leu Thr Lys Glu Thr Leu His Lys Gln Tyr His 
                245                 250                 255     


Leu Val Lys Ser His Thr Asn Thr Ser His Val Met Gln Tyr Gly Asn 
            260                 265                 270         


Lys Thr Ile Ser Thr Met Lys Val Met Gln Phe Gln Gly Met Lys Arg 
        275                 280                 285             


Lys Ala Ser Ser Pro Val Pro Leu Pro Pro Val Thr His Leu Asp Leu 
    290                 295                 300                 


Thr Pro Ser Pro Asp Val Pro Leu Thr Ile Met Lys Arg Lys Leu Met 
305                 310                 315                 320 


Asn Thr Asn Asp Leu Glu Glu Ser Arg Gln Leu Thr Glu Glu Ile Gln 
                325                 330                 335     


Arg His Leu Asp Ala Arg His Leu Ile Glu Lys Ser Val Arg Lys Ile 
            340                 345                 350         


Val Ser Leu Leu Ala Ala Ser Glu Ala Glu Val Glu Gln Leu Leu Ser 
        355                 360                 365             


Glu Arg Ala Pro Leu Thr Gly His Ser Cys Tyr Pro Glu Ala Leu Leu 
    370                 375                 380                 


His Phe Arg Thr His Cys Phe Asn Trp His Ser Pro Thr Tyr Glu Tyr 
385                 390                 395                 400 


Ala Leu Arg His Leu Tyr Val Leu Val Asn Leu Cys Glu Lys Pro Tyr 
                405                 410                 415     


Pro Leu His Arg Ile Lys Leu Ser Met Asp His Val Cys Leu Gly His 
            420                 425                 430         


Tyr 
    


<210>  7842
<211>  376
<212>  PRT
<213>  Homo Sapiens

<400>  7842

Met Val Trp Lys Val Ala Val Phe Leu Ser Val Ala Leu Gly Ile Gly 
1               5                   10                  15      


Ala Val Pro Ile Asp Asp Pro Glu Asp Gly Gly Lys His Trp Val Val 
            20                  25                  30          


Ile Val Ala Gly Ser Asn Gly Trp Tyr Asn Tyr Arg His Gln Ala Asp 
        35                  40                  45              


Ala Cys His Ala Tyr Gln Ile Ile His Arg Asn Gly Ile Pro Asp Glu 
    50                  55                  60                  


Gln Ile Val Val Met Met Tyr Asp Asp Ile Ala Tyr Ser Glu Asp Asn 
65                  70                  75                  80  


Pro Thr Pro Gly Ile Val Ile Asn Arg Pro Asn Gly Thr Asp Val Tyr 
                85                  90                  95      


Gln Gly Val Pro Lys Asp Tyr Thr Gly Glu Asp Val Thr Pro Gln Asn 
            100                 105                 110         


Phe Leu Ala Val Leu Arg Gly Asp Ala Glu Ala Val Lys Gly Ile Gly 
        115                 120                 125             


Ser Gly Lys Val Leu Lys Ser Gly Pro Gln Asp His Val Phe Ile Tyr 
    130                 135                 140                 


Phe Thr Asp His Gly Ser Thr Gly Ile Leu Val Phe Pro Asn Glu Asp 
145                 150                 155                 160 


Leu His Val Lys Asp Leu Asn Glu Thr Ile His Tyr Met Tyr Lys His 
                165                 170                 175     


Lys Met Tyr Arg Lys Met Val Phe Tyr Ile Glu Ala Cys Glu Ser Gly 
            180                 185                 190         


Ser Met Met Asn His Leu Pro Asp Asn Ile Asn Val Tyr Ala Thr Thr 
        195                 200                 205             


Ala Ala Asn Pro Arg Glu Ser Ser Tyr Ala Cys Tyr Tyr Asp Glu Lys 
    210                 215                 220                 


Arg Ser Thr Tyr Leu Gly Asp Trp Tyr Ser Val Asn Trp Met Glu Asp 
225                 230                 235                 240 


Ser Asp Val Glu Asp Leu Thr Lys Glu Thr Leu His Lys Gln Tyr His 
                245                 250                 255     


Leu Val Lys Ser His Thr Asn Thr Ser His Val Met Gln Tyr Gly Asn 
            260                 265                 270         


Lys Thr Ile Ser Thr Met Lys Val Met Gln Phe Gln Gly Met Lys Arg 
        275                 280                 285             


Lys Ala Ser Ser Pro Val Pro Leu Pro Pro Val Thr His Leu Asp Leu 
    290                 295                 300                 


Thr Pro Ser Pro Asp Val Pro Leu Thr Ile Met Lys Arg Lys Leu Met 
305                 310                 315                 320 


Asn Thr Asn Asp Leu Glu Glu Ser Arg Gln Leu Thr Glu Glu Ile Gln 
                325                 330                 335     


Arg His Leu Asp Tyr Glu Tyr Ala Leu Arg His Leu Tyr Val Leu Val 
            340                 345                 350         


Asn Leu Cys Glu Lys Pro Tyr Pro Leu His Arg Ile Lys Leu Ser Met 
        355                 360                 365             


Asp His Val Cys Leu Gly His Tyr 
    370                 375     


<210>  7843
<211>  372
<212>  PRT
<213>  Homo Sapiens

<400>  7843

Met Val Trp Lys Val Ala Val Phe Leu Ser Val Ala Leu Gly Ile Gly 
1               5                   10                  15      


Ala Val Pro Ile Asp Asp Pro Glu Asp Gly Gly Lys His Trp Val Val 
            20                  25                  30          


Ile Val Ala Gly Ser Asn Gly Trp Tyr Asn Tyr Arg His Gln Ala Asp 
        35                  40                  45              


Ala Cys His Ala Tyr Gln Ile Ile His Arg Asn Gly Ile Pro Asp Glu 
    50                  55                  60                  


Gln Ile Val Val Met Met Tyr Asp Asp Ile Ala Tyr Ser Glu Asp Asn 
65                  70                  75                  80  


Pro Thr Pro Gly Ile Val Ile Asn Arg Pro Asn Gly Thr Asp Val Tyr 
                85                  90                  95      


Gln Gly Val Pro Lys Asp Tyr Thr Gly Glu Asp Val Thr Pro Gln Asn 
            100                 105                 110         


Phe Leu Ala Val Leu Arg Gly Asp Ala Glu Ala Val Lys Gly Ile Gly 
        115                 120                 125             


Ser Gly Lys Val Leu Lys Ser Gly Pro Gln Asp His Val Phe Ile Tyr 
    130                 135                 140                 


Phe Thr Asp His Gly Ser Thr Gly Ile Leu Val Phe Pro Asn Glu Asp 
145                 150                 155                 160 


Leu His Val Lys Asp Leu Asn Glu Thr Ile His Tyr Met Tyr Lys His 
                165                 170                 175     


Lys Met Tyr Arg Lys Met Val Phe Tyr Ile Glu Ala Cys Glu Ser Gly 
            180                 185                 190         


Ser Met Met Asn His Leu Pro Asp Asn Ile Asn Val Tyr Ala Thr Thr 
        195                 200                 205             


Ala Ala Asn Pro Arg Glu Ser Ser Tyr Ala Cys Tyr Tyr Asp Glu Lys 
    210                 215                 220                 


Arg Ser Thr Tyr Leu Gly Asp Trp Tyr Ser Val Asn Trp Met Glu Asp 
225                 230                 235                 240 


Ser Asp Val Glu Asp Leu Thr Lys Glu Thr Leu His Lys Gln Tyr His 
                245                 250                 255     


Leu Val Lys Ser His Thr Asn Thr Ser His Val Met Gln Tyr Gly Asn 
            260                 265                 270         


Lys Thr Ile Ser Thr Met Lys Val Met Gln Phe Gln Gly Met Lys Arg 
        275                 280                 285             


Lys Ala Ser Ser Pro Val Pro Leu Pro Pro Val Thr His Leu Asp Leu 
    290                 295                 300                 


Thr Pro Ser Pro Asp Val Pro Leu Thr Ile Met Lys Arg Lys Leu Met 
305                 310                 315                 320 


Asn Thr Asn Asp Leu Glu Glu Ser Arg Gln Leu Thr Glu Glu Ile Gln 
                325                 330                 335     


Arg His Leu Asp Asp Lys Ile Val His Gly Pro Arg Val Pro Trp Ser 
            340                 345                 350         


Leu Leu Lys Ser Cys Leu Leu Glu Ala Phe Pro Ser Val Ser Ala Pro 
        355                 360                 365             


Pro Thr Val Cys 
    370         


<210>  7844
<211>  117
<212>  PRT
<213>  Homo Sapiens

<400>  7844

Met Val Trp Lys Val Ala Val Phe Leu Ser Val Ala Leu Gly Ile Gly 
1               5                   10                  15      


Ala Val Pro Ile Asp Asp Pro Glu Asp Gly Gly Lys His Trp Val Val 
            20                  25                  30          


Ile Val Ala Gly Ser Asn Gly Trp Tyr Asn Tyr Arg His Gln Ala Asp 
        35                  40                  45              


Ala Cys His Ala Tyr Gln Ile Ile His Arg Asn Gly Ile Pro Asp Glu 
    50                  55                  60                  


Gln Ile Val Val Met Met Tyr Asp Asp Ile Ala Tyr Ser Glu Asp Asn 
65                  70                  75                  80  


Pro Thr Pro Gly Ile Val Ile Asn Arg Pro Asn Gly Thr Asp Val Tyr 
                85                  90                  95      


Gln Gly Val Pro Lys Asp Tyr Thr Gly Glu Trp Pro Pro Gly Ser Arg 
            100                 105                 110         


Val His Leu Leu His 
        115         


<210>  7845
<211>  48
<212>  PRT
<213>  Homo Sapiens

<400>  7845

Met Val Trp Lys Val Ala Val Phe Leu Ser Val Ala Leu Gly Ile Gly 
1               5                   10                  15      


Ala Val Pro Ile Asp Asp Pro Glu Asp Gly Gly Lys His Trp Val Val 
            20                  25                  30          


Ile Val Ala Gly Ser Asn Gly Trp Tyr Asn Tyr Arg His Gln Glu Leu 
        35                  40                  45              


<210>  7846
<211>  91
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7846

Xaa Pro Thr Pro Gly Ile Val Ile Asn Arg Pro Asn Gly Thr Asp Val 
1               5                   10                  15      


Tyr Gln Gly Val Pro Lys Asp Tyr Thr Gly Glu Asp Val Thr Pro Gln 
            20                  25                  30          


Asn Phe Leu Ala Val Leu Arg Gly Gly Val Arg Ser Leu Arg Cys Ser 
        35                  40                  45              


Gly Pro Pro Gly Glu Pro Pro Leu Gln Gly Ser Leu Gln Asp Leu Leu 
    50                  55                  60                  


His Lys Met Thr Cys Ser Leu Leu Pro Ala Ser Pro Val Phe Ser Glu 
65                  70                  75                  80  


Lys Leu Gln Ile Arg Val Gly Lys Ala Leu Tyr 
                85                  90      


<210>  7847
<211>  951
<212>  PRT
<213>  Homo Sapiens

<400>  7847

Met Pro Gly Pro Leu Gly Leu Leu Cys Phe Leu Ala Leu Gly Leu Leu 
1               5                   10                  15      


Gly Ser Ala Gly Pro Ser Gly Ala Ala Pro Pro Leu Cys Ala Ala Pro 
            20                  25                  30          


Cys Ser Cys Asp Gly Asp Arg Arg Val Asp Cys Ser Gly Lys Gly Leu 
        35                  40                  45              


Thr Ala Val Pro Glu Gly Leu Ser Ala Phe Thr Gln Ala Leu Asp Ile 
    50                  55                  60                  


Ser Met Asn Asn Ile Thr Gln Leu Pro Glu Asp Ala Phe Lys Asn Phe 
65                  70                  75                  80  


Pro Phe Leu Glu Glu Leu Gln Leu Ala Gly Asn Asp Leu Ser Phe Ile 
                85                  90                  95      


His Pro Lys Ala Leu Ser Gly Leu Lys Glu Leu Lys Val Leu Thr Leu 
            100                 105                 110         


Gln Asn Asn Gln Leu Lys Thr Val Pro Ser Glu Ala Ile Arg Gly Leu 
        115                 120                 125             


Ser Ala Leu Gln Ser Leu Arg Leu Asp Ala Asn His Ile Thr Ser Val 
    130                 135                 140                 


Pro Glu Asp Ser Phe Glu Gly Leu Val Gln Leu Arg His Leu Trp Leu 
145                 150                 155                 160 


Asp Asp Asn Ser Leu Thr Glu Val Pro Val His Pro Leu Ser Asn Leu 
                165                 170                 175     


Pro Thr Leu Gln Ala Leu Thr Leu Ala Leu Asn Lys Ile Ser Ser Ile 
            180                 185                 190         


Pro Asp Phe Ala Phe Thr Asn Leu Ser Ser Leu Val Val Leu His Leu 
        195                 200                 205             


His Asn Asn Lys Ile Arg Ser Leu Ser Gln His Cys Phe Asp Gly Leu 
    210                 215                 220                 


Asp Asn Leu Glu Thr Leu Asp Leu Asn Tyr Asn Asn Leu Gly Glu Phe 
225                 230                 235                 240 


Pro Gln Ala Ile Lys Ala Leu Pro Ser Leu Lys Glu Leu Gly Phe His 
                245                 250                 255     


Ser Asn Ser Ile Ser Val Ile Pro Asp Gly Ala Phe Asp Gly Asn Pro 
            260                 265                 270         


Leu Leu Arg Thr Ile His Leu Tyr Asp Asn Pro Leu Ser Phe Val Gly 
        275                 280                 285             


Asn Ser Ala Phe His Asn Leu Ser Asp Leu His Ser Leu Val Ile Arg 
    290                 295                 300                 


Gly Ala Ser Met Val Gln Gln Phe Pro Asn Leu Thr Gly Thr Val His 
305                 310                 315                 320 


Leu Glu Ser Leu Thr Leu Thr Gly Thr Lys Ile Ser Ser Ile Pro Asn 
                325                 330                 335     


Asn Leu Cys Gln Glu Gln Lys Met Leu Arg Thr Leu Asp Leu Ser Tyr 
            340                 345                 350         


Asn Asn Ile Arg Asp Leu Pro Ser Phe Asn Gly Cys His Ala Leu Glu 
        355                 360                 365             


Glu Ile Ser Leu Gln Arg Asn Gln Ile Tyr Gln Ile Lys Glu Gly Thr 
    370                 375                 380                 


Phe Gln Gly Leu Ile Ser Leu Arg Ile Leu Asp Leu Ser Arg Asn Leu 
385                 390                 395                 400 


Ile His Glu Ile His Ser Arg Ala Phe Ala Thr Leu Gly Pro Ile Thr 
                405                 410                 415     


Asn Leu Asp Val Ser Phe Asn Glu Leu Thr Ser Phe Pro Thr Glu Gly 
            420                 425                 430         


Leu Asn Gly Leu Asn Gln Leu Lys Leu Val Gly Asn Phe Lys Leu Lys 
        435                 440                 445             


Glu Ala Leu Ala Ala Lys Asp Phe Val Asn Leu Arg Ser Leu Ser Val 
    450                 455                 460                 


Pro Tyr Ala Tyr Gln Cys Cys Ala Phe Trp Gly Cys Asp Ser Tyr Ala 
465                 470                 475                 480 


Asn Leu Asn Thr Glu Asp Asn Ser Leu Gln Asp His Ser Val Ala Gln 
                485                 490                 495     


Glu Lys Gly Thr Ala Asp Ala Ala Asn Val Thr Ser Thr Leu Glu Asn 
            500                 505                 510         


Glu Glu His Ser Gln Ile Ile Ile His Cys Thr Pro Ser Thr Gly Ala 
        515                 520                 525             


Phe Lys Pro Cys Glu Tyr Leu Leu Gly Ser Trp Met Ile Arg Leu Thr 
    530                 535                 540                 


Val Trp Phe Ile Phe Leu Val Ala Leu Phe Phe Asn Leu Leu Val Ile 
545                 550                 555                 560 


Leu Thr Thr Phe Ala Ser Cys Thr Ser Leu Pro Ser Ser Lys Leu Phe 
                565                 570                 575     


Ile Gly Leu Ile Ser Val Ser Asn Leu Phe Met Gly Ile Tyr Thr Gly 
            580                 585                 590         


Ile Leu Thr Phe Leu Asp Ala Val Ser Trp Gly Arg Phe Ala Glu Phe 
        595                 600                 605             


Gly Ile Trp Trp Glu Thr Gly Ser Gly Cys Lys Val Ala Gly Phe Leu 
    610                 615                 620                 


Ala Val Phe Ser Ser Glu Ser Ala Ile Phe Leu Leu Met Leu Ala Thr 
625                 630                 635                 640 


Val Glu Arg Ser Leu Ser Ala Lys Asp Ile Met Lys Asn Gly Lys Ser 
                645                 650                 655     


Asn His Leu Lys Gln Phe Arg Val Ala Ala Leu Leu Ala Phe Leu Gly 
            660                 665                 670         


Ala Thr Val Ala Gly Cys Phe Pro Leu Phe His Arg Gly Glu Tyr Ser 
        675                 680                 685             


Ala Ser Pro Leu Cys Leu Pro Phe Pro Thr Gly Glu Thr Pro Ser Leu 
    690                 695                 700                 


Gly Phe Thr Val Thr Leu Val Leu Leu Asn Ser Leu Ala Phe Leu Leu 
705                 710                 715                 720 


Met Ala Val Ile Tyr Thr Lys Leu Tyr Cys Asn Leu Glu Lys Glu Asp 
                725                 730                 735     


Leu Ser Glu Asn Ser Gln Ser Ser Met Ile Lys His Val Ala Trp Leu 
            740                 745                 750         


Ile Phe Thr Asn Cys Ile Phe Phe Cys Pro Val Ala Phe Phe Ser Phe 
        755                 760                 765             


Ala Pro Leu Ile Thr Ala Ile Ser Ile Ser Pro Glu Ile Met Lys Ser 
    770                 775                 780                 


Val Thr Leu Ile Phe Phe Pro Leu Pro Ala Cys Leu Asn Pro Val Leu 
785                 790                 795                 800 


Tyr Val Phe Phe Asn Pro Lys Phe Lys Glu Asp Trp Lys Leu Leu Lys 
                805                 810                 815     


Arg Arg Val Thr Lys Lys Ser Gly Ser Val Ser Val Ser Ile Ser Ser 
            820                 825                 830         


Gln Gly Gly Cys Leu Glu Gln Asp Phe Tyr Tyr Asp Cys Gly Met Tyr 
        835                 840                 845             


Ser His Leu Gln Gly Asn Leu Thr Val Cys Asp Cys Cys Glu Ser Phe 
    850                 855                 860                 


Leu Leu Thr Lys Pro Val Ser Cys Lys His Leu Ile Lys Ser His Ser 
865                 870                 875                 880 


Cys Pro Ala Leu Ala Val Ala Ser Cys Gln Arg Pro Glu Gly Tyr Trp 
                885                 890                 895     


Ser Asp Cys Gly Thr Gln Ser Ala His Ser Asp Tyr Ala Asp Glu Glu 
            900                 905                 910         


Asp Ser Phe Val Ser Asp Ser Ser Asp Gln Val Gln Ala Cys Gly Arg 
        915                 920                 925             


Ala Cys Phe Tyr Gln Ser Arg Gly Phe Pro Leu Val Arg Tyr Ala Tyr 
    930                 935                 940                 


Asn Leu Pro Arg Val Lys Asp 
945                 950     


<210>  7848
<211>  158
<212>  PRT
<213>  Homo Sapiens

<400>  7848

Met Pro Gly Pro Leu Gly Leu Leu Cys Phe Leu Ala Leu Gly Leu Leu 
1               5                   10                  15      


Gly Ser Ala Gly Pro Ser Gly Ala Ala Pro Pro Leu Cys Ala Ala Pro 
            20                  25                  30          


Cys Ser Cys Asp Gly Asp Arg Arg Val Asp Cys Ser Gly Lys Gly Leu 
        35                  40                  45              


Thr Ala Val Pro Glu Gly Leu Ser Ala Phe Thr Gln Ala Leu Asp Ile 
    50                  55                  60                  


Ser Met Asn Asn Ile Thr Gln Leu Pro Glu Asp Ala Phe Lys Asn Phe 
65                  70                  75                  80  


Pro Phe Leu Glu Glu Leu Arg Leu Asp Ala Asn His Ile Thr Ser Val 
                85                  90                  95      


Pro Glu Asp Ser Phe Glu Gly Leu Val Gln Leu Arg His Leu Trp Leu 
            100                 105                 110         


Asp Asp Asn Ser Leu Thr Glu Val Pro Val His Pro Leu Ser Asn Leu 
        115                 120                 125             


Pro Thr Leu Gln Ala Leu Thr Leu Ala Leu Asn Lys Ile Ser Ser Ile 
    130                 135                 140                 


Pro Asp Phe Ala Phe Thr Asn Leu Ser Ser Leu Val Val Leu 
145                 150                 155             


<210>  7849
<211>  927
<212>  PRT
<213>  Homo Sapiens

<400>  7849

Met Pro Gly Pro Leu Gly Leu Leu Cys Phe Leu Ala Leu Gly Leu Leu 
1               5                   10                  15      


Gly Ser Ala Gly Pro Ser Gly Ala Ala Pro Pro Leu Cys Ala Ala Pro 
            20                  25                  30          


Cys Ser Cys Asp Gly Asp Arg Arg Val Asp Cys Ser Gly Lys Gly Leu 
        35                  40                  45              


Thr Ala Val Pro Glu Gly Leu Ser Ala Phe Thr Gln Ala Leu Gln Leu 
    50                  55                  60                  


Ala Gly Asn Asp Leu Ser Phe Ile His Pro Lys Ala Leu Ser Gly Leu 
65                  70                  75                  80  


Lys Glu Leu Lys Val Leu Thr Leu Gln Asn Asn Gln Leu Lys Thr Val 
                85                  90                  95      


Pro Ser Glu Ala Ile Arg Gly Leu Ser Ala Leu Gln Ser Leu Arg Leu 
            100                 105                 110         


Asp Ala Asn His Ile Thr Ser Val Pro Glu Asp Ser Phe Glu Gly Leu 
        115                 120                 125             


Val Gln Leu Arg His Leu Trp Leu Asp Asp Asn Ser Leu Thr Glu Val 
    130                 135                 140                 


Pro Val His Pro Leu Ser Asn Leu Pro Thr Leu Gln Ala Leu Thr Leu 
145                 150                 155                 160 


Ala Leu Asn Lys Ile Ser Ser Ile Pro Asp Phe Ala Phe Thr Asn Leu 
                165                 170                 175     


Ser Ser Leu Val Val Leu His Leu His Asn Asn Lys Ile Arg Ser Leu 
            180                 185                 190         


Ser Gln His Cys Phe Asp Gly Leu Asp Asn Leu Glu Thr Leu Asp Leu 
        195                 200                 205             


Asn Tyr Asn Asn Leu Gly Glu Phe Pro Gln Ala Ile Lys Ala Leu Pro 
    210                 215                 220                 


Ser Leu Lys Glu Leu Gly Phe His Ser Asn Ser Ile Ser Val Ile Pro 
225                 230                 235                 240 


Asp Gly Ala Phe Asp Gly Asn Pro Leu Leu Arg Thr Ile His Leu Tyr 
                245                 250                 255     


Asp Asn Pro Leu Ser Phe Val Gly Asn Ser Ala Phe His Asn Leu Ser 
            260                 265                 270         


Asp Leu His Ser Leu Val Ile Arg Gly Ala Ser Met Val Gln Gln Phe 
        275                 280                 285             


Pro Asn Leu Thr Gly Thr Val His Leu Glu Ser Leu Thr Leu Thr Gly 
    290                 295                 300                 


Thr Lys Ile Ser Ser Ile Pro Asn Asn Leu Cys Gln Glu Gln Lys Met 
305                 310                 315                 320 


Leu Arg Thr Leu Asp Leu Ser Tyr Asn Asn Ile Arg Asp Leu Pro Ser 
                325                 330                 335     


Phe Asn Gly Cys His Ala Leu Glu Glu Ile Ser Leu Gln Arg Asn Gln 
            340                 345                 350         


Ile Tyr Gln Ile Lys Glu Gly Thr Phe Gln Gly Leu Ile Ser Leu Arg 
        355                 360                 365             


Ile Leu Asp Leu Ser Arg Asn Leu Ile His Glu Ile His Ser Arg Ala 
    370                 375                 380                 


Phe Ala Thr Leu Gly Pro Ile Thr Asn Leu Asp Val Ser Phe Asn Glu 
385                 390                 395                 400 


Leu Thr Ser Phe Pro Thr Glu Gly Leu Asn Gly Leu Asn Gln Leu Lys 
                405                 410                 415     


Leu Val Gly Asn Phe Lys Leu Lys Glu Ala Leu Ala Ala Lys Asp Phe 
            420                 425                 430         


Val Asn Leu Arg Ser Leu Ser Val Pro Tyr Ala Tyr Gln Cys Cys Ala 
        435                 440                 445             


Phe Trp Gly Cys Asp Ser Tyr Ala Asn Leu Asn Thr Glu Asp Asn Ser 
    450                 455                 460                 


Leu Gln Asp His Ser Val Ala Gln Glu Lys Gly Thr Ala Asp Ala Ala 
465                 470                 475                 480 


Asn Val Thr Ser Thr Leu Glu Asn Glu Glu His Ser Gln Ile Ile Ile 
                485                 490                 495     


His Cys Thr Pro Ser Thr Gly Ala Phe Lys Pro Cys Glu Tyr Leu Leu 
            500                 505                 510         


Gly Ser Trp Met Ile Arg Leu Thr Val Trp Phe Ile Phe Leu Val Ala 
        515                 520                 525             


Leu Phe Phe Asn Leu Leu Val Ile Leu Thr Thr Phe Ala Ser Cys Thr 
    530                 535                 540                 


Ser Leu Pro Ser Ser Lys Leu Phe Ile Gly Leu Ile Ser Val Ser Asn 
545                 550                 555                 560 


Leu Phe Met Gly Ile Tyr Thr Gly Ile Leu Thr Phe Leu Asp Ala Val 
                565                 570                 575     


Ser Trp Gly Arg Phe Ala Glu Phe Gly Ile Trp Trp Glu Thr Gly Ser 
            580                 585                 590         


Gly Cys Lys Val Ala Gly Phe Leu Ala Val Phe Ser Ser Glu Ser Ala 
        595                 600                 605             


Ile Phe Leu Leu Met Leu Ala Thr Val Glu Arg Ser Leu Ser Ala Lys 
    610                 615                 620                 


Asp Ile Met Lys Asn Gly Lys Ser Asn His Leu Lys Gln Phe Arg Val 
625                 630                 635                 640 


Ala Ala Leu Leu Ala Phe Leu Gly Ala Thr Val Ala Gly Cys Phe Pro 
                645                 650                 655     


Leu Phe His Arg Gly Glu Tyr Ser Ala Ser Pro Leu Cys Leu Pro Phe 
            660                 665                 670         


Pro Thr Gly Glu Thr Pro Ser Leu Gly Phe Thr Val Thr Leu Val Leu 
        675                 680                 685             


Leu Asn Ser Leu Ala Phe Leu Leu Met Ala Val Ile Tyr Thr Lys Leu 
    690                 695                 700                 


Tyr Cys Asn Leu Glu Lys Glu Asp Leu Ser Glu Asn Ser Gln Ser Ser 
705                 710                 715                 720 


Met Ile Lys His Val Ala Trp Leu Ile Phe Thr Asn Cys Ile Phe Phe 
                725                 730                 735     


Cys Pro Val Ala Phe Phe Ser Phe Ala Pro Leu Ile Thr Ala Ile Ser 
            740                 745                 750         


Ile Ser Pro Glu Ile Met Lys Ser Val Thr Leu Ile Phe Phe Pro Leu 
        755                 760                 765             


Pro Ala Cys Leu Asn Pro Val Leu Tyr Val Phe Phe Asn Pro Lys Phe 
    770                 775                 780                 


Lys Glu Asp Trp Lys Leu Leu Lys Arg Arg Val Thr Lys Lys Ser Gly 
785                 790                 795                 800 


Ser Val Ser Val Ser Ile Ser Ser Gln Gly Gly Cys Leu Glu Gln Asp 
                805                 810                 815     


Phe Tyr Tyr Asp Cys Gly Met Tyr Ser His Leu Gln Gly Asn Leu Thr 
            820                 825                 830         


Val Cys Asp Cys Cys Glu Ser Phe Leu Leu Thr Lys Pro Val Ser Cys 
        835                 840                 845             


Lys His Leu Ile Lys Ser His Ser Cys Pro Ala Leu Ala Val Ala Ser 
    850                 855                 860                 


Cys Gln Arg Pro Glu Gly Tyr Trp Ser Asp Cys Gly Thr Gln Ser Ala 
865                 870                 875                 880 


His Ser Asp Tyr Ala Asp Glu Glu Asp Ser Phe Val Ser Asp Ser Ser 
                885                 890                 895     


Asp Gln Val Gln Ala Cys Gly Arg Ala Cys Phe Tyr Gln Ser Arg Gly 
            900                 905                 910         


Phe Pro Leu Val Arg Tyr Ala Tyr Asn Leu Pro Arg Val Lys Asp 
        915                 920                 925         


<210>  7850
<211>  141
<212>  PRT
<213>  Homo Sapiens

<400>  7850

Met Glu Met Leu Gln Gly Leu Leu Leu Leu Leu Leu Leu Ser Met Gly 
1               5                   10                  15      


Gly Ala Trp Ala Ser Arg Glu Pro Leu Arg Pro Trp Cys His Pro Ile 
            20                  25                  30          


Asn Ala Ile Leu Ala Val Glu Lys Glu Gly Cys Pro Val Cys Ile Thr 
        35                  40                  45              


Val Asn Thr Thr Ile Cys Ala Gly Tyr Cys Pro Thr Met Met Arg Val 
    50                  55                  60                  


Leu Gln Ala Val Leu Pro Pro Leu Pro Gln Val Val Cys Thr Tyr Arg 
65                  70                  75                  80  


Asp Val Arg Phe Glu Ser Ile Arg Leu Pro Gly Cys Pro Arg Gly Val 
                85                  90                  95      


Asp Pro Val Val Ser Phe Pro Val Ala Leu Ser Cys Arg Cys Gly Pro 
            100                 105                 110         


Cys Arg Arg Ser Thr Ser Asp Cys Gly Gly Pro Lys Asp His Pro Leu 
        115                 120                 125             


Thr Cys Asp His Pro Gln Leu Ser Gly Leu Leu Phe Leu 
    130                 135                 140     


<210>  7851
<211>  699
<212>  PRT
<213>  Homo Sapiens

<400>  7851

Met Lys Gln Arg Phe Ser Ala Leu Gln Leu Leu Lys Leu Leu Leu Leu 
1               5                   10                  15      


Leu Gln Pro Pro Leu Pro Arg Ala Leu Arg Glu Ala Leu Cys Pro Glu 
            20                  25                  30          


Pro Cys Asn Cys Val Pro Asp Gly Ala Leu Arg Cys Pro Gly Pro Thr 
        35                  40                  45              


Ala Gly Leu Thr Arg Leu Ser Leu Ala Tyr Leu Pro Val Lys Val Ile 
    50                  55                  60                  


Pro Ser Gln Ala Phe Arg Gly Leu Asn Glu Val Ile Lys Ile Glu Ile 
65                  70                  75                  80  


Ser Gln Ile Asp Ser Leu Glu Arg Ile Glu Ala Asn Ala Phe Asp Asn 
                85                  90                  95      


Leu Leu Asn Leu Ser Glu Ile Leu Ile Gln Asn Thr Lys Asn Leu Arg 
            100                 105                 110         


Tyr Ile Glu Pro Gly Ala Phe Ile Asn Leu Pro Arg Leu Lys Tyr Leu 
        115                 120                 125             


Ser Ile Cys Asn Thr Gly Ile Arg Lys Phe Pro Asp Val Thr Lys Val 
    130                 135                 140                 


Phe Ser Ser Glu Ser Asn Phe Ile Leu Glu Ile Cys Asp Asn Leu His 
145                 150                 155                 160 


Ile Thr Thr Ile Pro Gly Asn Ala Phe Gln Gly Met Asn Asn Glu Ser 
                165                 170                 175     


Val Thr Leu Lys Leu Tyr Gly Asn Gly Phe Glu Glu Val Gln Ser His 
            180                 185                 190         


Ala Phe Asn Gly Thr Thr Leu Thr Ser Leu Glu Leu Lys Glu Asn Val 
        195                 200                 205             


His Leu Glu Lys Met His Asn Gly Ala Phe Arg Gly Ala Thr Gly Pro 
    210                 215                 220                 


Lys Thr Leu Asp Ile Ser Ser Thr Lys Leu Gln Ala Leu Pro Ser Tyr 
225                 230                 235                 240 


Gly Leu Glu Ser Ile Gln Arg Leu Ile Ala Thr Ser Ser Tyr Ser Leu 
                245                 250                 255     


Lys Lys Leu Pro Ser Arg Glu Thr Phe Val Asn Leu Leu Glu Ala Thr 
            260                 265                 270         


Leu Thr Tyr Pro Ser His Cys Cys Ala Phe Arg Asn Leu Pro Thr Lys 
        275                 280                 285             


Glu Gln Asn Phe Ser His Ser Ile Ser Glu Asn Phe Ser Lys Gln Cys 
    290                 295                 300                 


Glu Ser Thr Val Arg Lys Val Asn Asn Lys Thr Leu Tyr Ser Ser Met 
305                 310                 315                 320 


Leu Ala Glu Ser Glu Leu Ser Gly Trp Asp Tyr Glu Tyr Gly Phe Cys 
                325                 330                 335     


Leu Pro Lys Thr Pro Arg Cys Ala Pro Glu Pro Asp Ala Phe Asn Pro 
            340                 345                 350         


Cys Glu Asp Ile Met Gly Tyr Asp Phe Leu Arg Val Leu Ile Trp Leu 
        355                 360                 365             


Ile Asn Ile Leu Ala Ile Met Gly Asn Met Thr Val Leu Phe Val Leu 
    370                 375                 380                 


Leu Thr Ser Arg Tyr Lys Leu Thr Val Pro Arg Phe Leu Met Cys Asn 
385                 390                 395                 400 


Leu Ser Phe Ala Asp Phe Cys Met Gly Leu Tyr Leu Leu Leu Ile Ala 
                405                 410                 415     


Ser Val Asp Ser Gln Thr Lys Gly Gln Tyr Tyr Asn His Ala Ile Asp 
            420                 425                 430         


Trp Gln Thr Gly Ser Gly Cys Ser Thr Ala Gly Phe Phe Thr Val Phe 
        435                 440                 445             


Ala Ser Glu Leu Ser Val Tyr Thr Leu Thr Val Ile Thr Leu Glu Arg 
    450                 455                 460                 


Trp His Thr Ile Thr Tyr Ala Ile His Leu Asp Gln Lys Leu Arg Leu 
465                 470                 475                 480 


Arg His Ala Ile Leu Ile Met Leu Gly Gly Trp Leu Phe Ser Ser Leu 
                485                 490                 495     


Ile Ala Met Leu Pro Leu Val Gly Val Ser Asn Tyr Met Lys Val Ser 
            500                 505                 510         


Ile Cys Phe Pro Met Asp Val Glu Thr Thr Leu Ser Gln Val Tyr Ile 
        515                 520                 525             


Leu Thr Ile Leu Ile Leu Asn Val Val Ala Phe Phe Ile Ile Cys Ala 
    530                 535                 540                 


Cys Tyr Ile Lys Ile Tyr Phe Ala Val Arg Asn Pro Glu Leu Met Ala 
545                 550                 555                 560 


Thr Asn Lys Asp Thr Lys Ile Ala Lys Lys Met Ala Ile Leu Ile Phe 
                565                 570                 575     


Thr Asp Phe Thr Cys Met Ala Pro Ile Ser Phe Phe Ala Ile Ser Ala 
            580                 585                 590         


Ala Phe Lys Val Pro Leu Ile Thr Val Thr Asn Ser Lys Val Leu Leu 
        595                 600                 605             


Val Leu Phe Tyr Pro Ile Asn Ser Cys Ala Asn Pro Phe Leu Tyr Ala 
    610                 615                 620                 


Ile Phe Thr Lys Thr Phe Gln Arg Asp Phe Phe Leu Leu Leu Ser Lys 
625                 630                 635                 640 


Phe Gly Cys Cys Lys Arg Arg Ala Glu Leu Tyr Arg Arg Lys Asp Phe 
                645                 650                 655     


Ser Ala Tyr Thr Ser Asn Cys Lys Asn Gly Phe Thr Gly Ser Asn Lys 
            660                 665                 670         


Pro Ser Gln Ser Thr Leu Lys Leu Ser Thr Leu His Cys Gln Gly Thr 
        675                 680                 685             


Ala Leu Leu Asp Lys Thr Arg Tyr Thr Glu Cys 
    690                 695                 


<210>  7852
<211>  672
<212>  PRT
<213>  Homo Sapiens

<400>  7852

Met Lys Gln Arg Phe Ser Ala Leu Gln Leu Leu Lys Leu Leu Leu Leu 
1               5                   10                  15      


Leu Gln Pro Pro Leu Pro Arg Ala Leu Arg Glu Ala Leu Cys Pro Glu 
            20                  25                  30          


Pro Cys Asn Cys Val Pro Asp Gly Ala Leu Arg Cys Pro Gly Pro Thr 
        35                  40                  45              


Ala Gly Leu Thr Arg Leu Ser Leu Ala Tyr Leu Pro Val Lys Val Ile 
    50                  55                  60                  


Pro Ser Gln Ala Phe Arg Gly Leu Asn Glu Val Ile Lys Ile Glu Ile 
65                  70                  75                  80  


Ser Gln Ile Asp Ser Leu Glu Arg Ile Glu Ala Asn Ala Phe Asp Asn 
                85                  90                  95      


Leu Leu Asn Leu Ser Glu Ile Leu Ile Gln Asn Thr Lys Asn Leu Arg 
            100                 105                 110         


Tyr Ile Glu Pro Gly Ala Phe Ile Asn Leu Pro Arg Leu Lys Tyr Leu 
        115                 120                 125             


Ser Ile Cys Asn Thr Gly Ile Arg Lys Phe Pro Asp Val Thr Lys Val 
    130                 135                 140                 


Phe Ser Ser Glu Ser Asn Phe Ile Leu Glu Ile Cys Asp Asn Leu His 
145                 150                 155                 160 


Ile Thr Thr Ile Pro Gly Asn Ala Phe Gln Gly Met Asn Asn Glu Ser 
                165                 170                 175     


Val Thr Leu Lys Leu Tyr Gly Asn Gly Phe Glu Glu Val Gln Ser His 
            180                 185                 190         


Ala Phe Asn Gly Thr Thr Leu Thr Ser Leu Glu Leu Lys Glu Asn Val 
        195                 200                 205             


His Leu Glu Lys Met His Asn Gly Ala Phe Arg Gly Ala Thr Gly Pro 
    210                 215                 220                 


Lys Thr Leu Asp Ile Ser Ser Thr Lys Leu Gln Ala Leu Pro Ser Tyr 
225                 230                 235                 240 


Gly Leu Glu Ser Ile Gln Arg Leu Ile Ala Thr Ser Ser Tyr Ser Leu 
                245                 250                 255     


Lys Lys Leu Pro Ser Arg Glu Thr Phe Val Asn Leu Leu Glu Ala Thr 
            260                 265                 270         


Leu Thr Tyr Pro Ser His Cys Cys Ala Phe Arg Asn Leu Pro Thr Lys 
        275                 280                 285             


Asp Tyr Ser Ser Met Leu Ala Glu Ser Glu Leu Ser Gly Trp Asp Tyr 
    290                 295                 300                 


Glu Tyr Gly Phe Cys Leu Pro Lys Thr Pro Arg Cys Ala Pro Glu Pro 
305                 310                 315                 320 


Asp Ala Phe Asn Pro Cys Glu Asp Ile Met Gly Tyr Asp Phe Leu Arg 
                325                 330                 335     


Val Leu Ile Trp Leu Ile Asn Ile Leu Ala Ile Met Gly Asn Met Thr 
            340                 345                 350         


Val Leu Phe Val Leu Leu Thr Ser Arg Tyr Lys Leu Thr Val Pro Arg 
        355                 360                 365             


Phe Leu Met Cys Asn Leu Ser Phe Ala Asp Phe Cys Met Gly Leu Tyr 
    370                 375                 380                 


Leu Leu Leu Ile Ala Ser Val Asp Ser Gln Thr Lys Gly Gln Tyr Tyr 
385                 390                 395                 400 


Asn His Ala Ile Asp Trp Gln Thr Gly Ser Gly Cys Ser Thr Ala Gly 
                405                 410                 415     


Phe Phe Thr Val Phe Ala Ser Glu Leu Ser Val Tyr Thr Leu Thr Val 
            420                 425                 430         


Ile Thr Leu Glu Arg Trp His Thr Ile Thr Tyr Ala Ile His Leu Asp 
        435                 440                 445             


Gln Lys Leu Arg Leu Arg His Ala Ile Leu Ile Met Leu Gly Gly Trp 
    450                 455                 460                 


Leu Phe Ser Ser Leu Ile Ala Met Leu Pro Leu Val Gly Val Ser Asn 
465                 470                 475                 480 


Tyr Met Lys Val Ser Ile Cys Phe Pro Met Asp Val Glu Thr Thr Leu 
                485                 490                 495     


Ser Gln Val Tyr Ile Leu Thr Ile Leu Ile Leu Asn Val Val Ala Phe 
            500                 505                 510         


Phe Ile Ile Cys Ala Cys Tyr Ile Lys Ile Tyr Phe Ala Val Arg Asn 
        515                 520                 525             


Pro Glu Leu Met Ala Thr Asn Lys Asp Thr Lys Ile Ala Lys Lys Met 
    530                 535                 540                 


Ala Ile Leu Ile Phe Thr Asp Phe Thr Cys Met Ala Pro Ile Ser Phe 
545                 550                 555                 560 


Phe Ala Ile Ser Ala Ala Phe Lys Val Pro Leu Ile Thr Val Thr Asn 
                565                 570                 575     


Ser Lys Val Leu Leu Val Leu Phe Tyr Pro Ile Asn Ser Cys Ala Asn 
            580                 585                 590         


Pro Phe Leu Tyr Ala Ile Phe Thr Lys Thr Phe Gln Arg Asp Phe Phe 
        595                 600                 605             


Leu Leu Leu Ser Lys Phe Gly Cys Cys Lys Arg Arg Ala Glu Leu Tyr 
    610                 615                 620                 


Arg Arg Lys Asp Phe Ser Ala Tyr Thr Ser Asn Cys Lys Asn Gly Phe 
625                 630                 635                 640 


Thr Gly Ser Asn Lys Pro Ser Gln Ser Thr Leu Lys Leu Ser Thr Leu 
                645                 650                 655     


His Cys Gln Gly Thr Ala Leu Leu Asp Lys Thr Arg Tyr Thr Glu Cys 
            660                 665                 670         


<210>  7853
<211>  325
<212>  PRT
<213>  Homo Sapiens

<400>  7853

Met Lys Gln Arg Phe Ser Ala Leu Gln Leu Leu Lys Leu Leu Leu Leu 
1               5                   10                  15      


Leu Gln Pro Pro Leu Pro Arg Ala Leu Arg Glu Ala Leu Cys Pro Glu 
            20                  25                  30          


Pro Cys Asn Cys Val Pro Asp Gly Ala Leu Arg Cys Pro Gly Pro Thr 
        35                  40                  45              


Ala Gly Leu Thr Arg Leu Ser Leu Ala Tyr Leu Pro Val Lys Val Ile 
    50                  55                  60                  


Pro Ser Gln Ala Phe Arg Gly Leu Asn Glu Val Ile Lys Ile Glu Ile 
65                  70                  75                  80  


Ser Gln Ile Asp Ser Leu Glu Arg Ile Glu Ala Asn Ala Phe Asp Asn 
                85                  90                  95      


Leu Leu Asn Leu Ser Glu Ile Leu Ile Gln Asn Thr Lys Asn Leu Arg 
            100                 105                 110         


Tyr Ile Glu Pro Gly Ala Phe Ile Asn Leu Pro Arg Leu Lys Tyr Leu 
        115                 120                 125             


Ser Ile Cys Asn Thr Gly Ile Arg Lys Phe Pro Asp Val Thr Lys Val 
    130                 135                 140                 


Phe Ser Ser Glu Ser Asn Phe Ile Leu Glu Ile Cys Asp Asn Leu His 
145                 150                 155                 160 


Ile Thr Thr Ile Pro Gly Asn Ala Phe Gln Gly Met Asn Asn Glu Ser 
                165                 170                 175     


Val Thr Leu Lys Leu Tyr Gly Asn Gly Phe Glu Glu Val Gln Ser His 
            180                 185                 190         


Ala Phe Asn Gly Thr Thr Leu Thr Ser Leu Glu Leu Lys Glu Asn Val 
        195                 200                 205             


His Leu Glu Lys Met His Asn Gly Ala Phe Arg Gly Ala Thr Gly Pro 
    210                 215                 220                 


Lys Thr Leu Asp Ile Ser Ser Thr Lys Leu Gln Ala Leu Pro Ser Tyr 
225                 230                 235                 240 


Gly Leu Glu Ser Ile Gln Arg Leu Ile Ala Thr Ser Ser Tyr Ser Leu 
                245                 250                 255     


Lys Lys Leu Pro Ser Arg Glu Thr Phe Val Asn Leu Leu Glu Ala Thr 
            260                 265                 270         


Leu Thr Tyr Pro Ser His Cys Cys Ala Phe Arg Asn Leu Pro Thr Lys 
        275                 280                 285             


Glu Gln Asn Phe Ser His Ser Ile Ser Glu Asn Phe Ser Lys Gln Cys 
    290                 295                 300                 


Glu Ser Thr Val Arg Lys Val Asn Asn Lys Thr Leu Ser Lys Pro Arg 
305                 310                 315                 320 


Ile Asn Gly Tyr Gln 
                325 


<210>  7854
<211>  329
<212>  PRT
<213>  Homo Sapiens

<400>  7854

Met Lys Gln Arg Phe Ser Ala Leu Gln Leu Leu Lys Leu Leu Leu Leu 
1               5                   10                  15      


Leu Gln Pro Pro Leu Pro Arg Ala Leu Arg Glu Ala Leu Cys Pro Glu 
            20                  25                  30          


Pro Cys Asn Cys Val Pro Asp Gly Ala Leu Arg Cys Pro Gly Pro Thr 
        35                  40                  45              


Ala Gly Leu Thr Arg Leu Ser Leu Ala Tyr Leu Pro Val Lys Val Ile 
    50                  55                  60                  


Pro Ser Gln Ala Phe Arg Gly Leu Asn Glu Val Ile Lys Ile Glu Ile 
65                  70                  75                  80  


Ser Gln Ile Asp Ser Leu Glu Arg Ile Glu Ala Asn Ala Phe Asp Asn 
                85                  90                  95      


Leu Leu Asn Leu Ser Glu Ile Leu Ile Gln Asn Thr Lys Asn Leu Arg 
            100                 105                 110         


Tyr Ile Glu Pro Gly Ala Phe Ile Asn Leu Pro Arg Leu Lys Tyr Leu 
        115                 120                 125             


Ser Ile Cys Asn Thr Gly Ile Arg Lys Phe Pro Asp Val Thr Lys Val 
    130                 135                 140                 


Phe Ser Ser Glu Ser Asn Phe Ile Leu Glu Ile Cys Asp Asn Leu His 
145                 150                 155                 160 


Ile Thr Thr Ile Pro Gly Asn Ala Phe Gln Gly Met Asn Asn Glu Ser 
                165                 170                 175     


Val Thr Leu Lys Leu Tyr Gly Asn Gly Phe Glu Glu Val Gln Ser His 
            180                 185                 190         


Ala Phe Asn Gly Thr Thr Leu Thr Ser Leu Glu Leu Lys Glu Asn Val 
        195                 200                 205             


His Leu Glu Lys Met His Asn Gly Ala Phe Arg Gly Ala Thr Gly Pro 
    210                 215                 220                 


Lys Thr Leu Asp Ile Ser Ser Thr Lys Leu Gln Ala Leu Pro Ser Tyr 
225                 230                 235                 240 


Gly Leu Glu Ser Ile Gln Arg Leu Ile Ala Thr Ser Ser Tyr Ser Leu 
                245                 250                 255     


Lys Lys Leu Pro Ser Arg Glu Thr Phe Val Asn Leu Leu Glu Ala Thr 
            260                 265                 270         


Leu Thr Tyr Pro Ser His Cys Cys Ala Phe Arg Asn Leu Pro Thr Lys 
        275                 280                 285             


Glu Gln Asn Phe Ser His Ser Ile Ser Glu Asn Phe Ser Lys Gln Cys 
    290                 295                 300                 


Glu Ser Thr Val Arg Lys Val Asn Asn Lys Thr Leu Leu Leu His Gly 
305                 310                 315                 320 


Ala Leu Ser Ala Ala His Ser Leu Ser 
                325                 


<210>  7855
<211>  175
<212>  PRT
<213>  Homo Sapiens

<400>  7855

Asn Cys Val Pro Asp Gly Ala Leu Arg Cys Pro Gly Pro Thr Ala Gly 
1               5                   10                  15      


Leu Thr Arg Leu Ser Leu Ala Tyr Leu Pro Val Lys Val Ile Pro Ser 
            20                  25                  30          


Gln Ala Phe Arg Gly Leu Asn Glu Val Ile Lys Ile Glu Ile Ser Gln 
        35                  40                  45              


Ile Asp Ser Leu Glu Arg Ile Glu Ala Asn Ala Phe Asp Asn Leu Leu 
    50                  55                  60                  


Asn Leu Ser Glu Ile Leu Ile Gln Asn Thr Lys Asn Leu Arg Tyr Ile 
65                  70                  75                  80  


Glu Pro Gly Ala Phe Ile Asn Leu Pro Arg Leu Lys Tyr Leu Ser Ile 
                85                  90                  95      


Cys Asn Thr Gly Ile Arg Lys Phe Pro Asp Val Thr Lys Val Phe Ser 
            100                 105                 110         


Ser Glu Ser Asn Phe Ile Leu Glu Ile Cys Asp Asn Leu His Ile Thr 
        115                 120                 125             


Thr Ile Pro Gly Asn Ala Phe Gln Gly Met Asn Asn Glu Ser Val Thr 
    130                 135                 140                 


Leu Pro Trp Gln Asn Cys Asp Glu Ala Ile Lys Glu Leu Thr Leu Lys 
145                 150                 155                 160 


Glu Lys Arg Glu Asn Met Asp Trp Asn Asp Ser Glu Met Lys Arg 
                165                 170                 175 


<210>  7856
<211>  202
<212>  PRT
<213>  Homo Sapiens

<400>  7856

Met Lys Val Leu Ala Ala Gly Val Val Pro Leu Leu Leu Val Leu His 
1               5                   10                  15      


Trp Lys His Gly Ala Gly Ser Pro Leu Pro Ile Thr Pro Val Asn Ala 
            20                  25                  30          


Thr Cys Ala Ile Arg His Pro Cys His Asn Asn Leu Met Asn Gln Ile 
        35                  40                  45              


Arg Ser Gln Leu Ala Gln Leu Asn Gly Ser Ala Asn Ala Leu Phe Ile 
    50                  55                  60                  


Leu Tyr Tyr Thr Ala Gln Gly Glu Pro Phe Pro Asn Asn Leu Asp Lys 
65                  70                  75                  80  


Leu Cys Gly Pro Asn Val Thr Asp Phe Pro Pro Phe His Ala Asn Gly 
                85                  90                  95      


Thr Glu Lys Ala Lys Leu Val Glu Leu Tyr Arg Ile Val Val Tyr Leu 
            100                 105                 110         


Gly Thr Ser Leu Gly Asn Ile Thr Arg Asp Gln Lys Ile Leu Asn Pro 
        115                 120                 125             


Ser Ala Leu Ser Leu His Ser Lys Leu Asn Ala Thr Ala Asp Ile Leu 
    130                 135                 140                 


Arg Gly Leu Leu Ser Asn Val Leu Cys Arg Leu Cys Ser Lys Tyr His 
145                 150                 155                 160 


Val Gly His Val Asp Val Thr Tyr Gly Pro Asp Thr Ser Gly Lys Asp 
                165                 170                 175     


Val Phe Gln Lys Lys Lys Leu Gly Cys Gln Leu Leu Gly Lys Tyr Lys 
            180                 185                 190         


Gln Ile Ile Ala Val Leu Ala Gln Ala Phe 
        195                 200         


<210>  7857
<211>  88
<212>  PRT
<213>  Homo Sapiens

<400>  7857

Met Lys Val Leu Ala Ala Val His Ser Pro Gly Gly Ala Val Pro Gln 
1               5                   10                  15      


Gln Pro Gly Gln Ala Met Trp Pro Gln Arg Asp Gly Leu Pro Ala Leu 
            20                  25                  30          


Pro Arg Gln Arg His Gly Glu Gly Gln Ala Gly Gly Ala Val Pro His 
        35                  40                  45              


Ser Arg Val Pro Trp His Leu Pro Gly Gln His His Pro Gly Pro Glu 
    50                  55                  60                  


Asp Pro Gln Pro Gln Cys Pro Gln Pro Pro Gln Gln Ala Gln Arg His 
65                  70                  75                  80  


Arg Arg His Pro Ala Arg Pro Pro 
                85              


<210>  7858
<211>  75
<212>  PRT
<213>  Homo Sapiens

<400>  7858

Met Met Asp Ile Tyr Val Cys Leu Lys Arg Pro Ser Trp Met Val Asp 
1               5                   10                  15      


Asn Lys Arg Met Arg Thr Ala Ser Asn Phe Gln Trp Leu Leu Ser Thr 
            20                  25                  30          


Phe Ile Leu Leu Tyr Leu Met Asn Gln Val Asn Ser Gln Lys Lys Gly 
        35                  40                  45              


Ala Pro His Asp Leu Lys Cys Val Thr Asn Asn Leu Gln Val Trp Asn 
    50                  55                  60                  


Cys Ser Trp Lys Ala Pro Ser Gly Thr Gly Arg 
65                  70                  75  


<210>  7859
<211>  126
<212>  PRT
<213>  Homo Sapiens

<400>  7859

Met Met Asp Ile Tyr Val Cys Leu Lys Arg Pro Ser Trp Met Val Asp 
1               5                   10                  15      


Asn Lys Arg Met Arg Thr Ala Ser Asn Phe Gln Trp Leu Leu Ser Thr 
            20                  25                  30          


Phe Ile Leu Leu Tyr Leu Met Asn Gln Val Asn Ser Gln Lys Lys Gly 
        35                  40                  45              


Ala Pro His Asp Leu Lys Cys Val Thr Asn Asn Leu Gln Val Trp Asn 
    50                  55                  60                  


Cys Ser Trp Lys Ala Pro Ser Gly Thr Gly Arg Gly Thr Asp Tyr Glu 
65                  70                  75                  80  


Val Cys Ile Glu Asn Arg Ser Arg Ser Cys Tyr Gln Leu Glu Lys Thr 
                85                  90                  95      


Ser Ile Lys Ile Pro Ala Leu Ser His Gly Asp Tyr Glu Ile Thr Ile 
            100                 105                 110         


Asn Ser Leu His Asp Phe Gly Ser Ser Thr Ser Lys Phe Thr 
        115                 120                 125     


<210>  7860
<211>  1097
<212>  PRT
<213>  Homo Sapiens

<400>  7860

Met Met Asp Ile Tyr Val Cys Leu Lys Arg Pro Ser Trp Met Val Asp 
1               5                   10                  15      


Asn Lys Arg Met Arg Thr Ala Ser Asn Phe Gln Trp Leu Leu Ser Thr 
            20                  25                  30          


Phe Ile Leu Leu Tyr Leu Met Asn Gln Val Asn Ser Gln Lys Lys Gly 
        35                  40                  45              


Ala Pro His Asp Leu Lys Cys Val Thr Asn Asn Leu Gln Val Trp Asn 
    50                  55                  60                  


Cys Ser Trp Lys Ala Pro Ser Gly Thr Gly Arg Gly Thr Asp Tyr Glu 
65                  70                  75                  80  


Val Cys Ile Glu Asn Arg Ser Arg Ser Cys Tyr Gln Leu Glu Lys Thr 
                85                  90                  95      


Ser Ile Lys Ile Pro Ala Leu Ser His Gly Asp Tyr Glu Ile Thr Ile 
            100                 105                 110         


Asn Ser Leu His Asp Phe Gly Ser Ser Thr Ser Lys Phe Thr Leu Asn 
        115                 120                 125             


Glu Gln Asn Val Ser Leu Ile Pro Asp Thr Pro Glu Ile Leu Asn Leu 
    130                 135                 140                 


Ser Ala Asp Phe Ser Thr Ser Thr Leu Tyr Leu Lys Trp Asn Asp Arg 
145                 150                 155                 160 


Gly Ser Val Phe Pro His Arg Ser Asn Val Ile Trp Glu Ile Lys Val 
                165                 170                 175     


Leu Arg Lys Glu Ser Met Glu Leu Val Lys Leu Val Thr His Asn Thr 
            180                 185                 190         


Thr Leu Asn Gly Lys Asp Thr Leu His His Trp Ser Trp Ala Ser Asp 
        195                 200                 205             


Met Pro Leu Glu Cys Ala Ile His Phe Val Glu Ile Arg Cys Tyr Ile 
    210                 215                 220                 


Asp Asn Leu His Phe Ser Gly Leu Glu Glu Trp Ser Asp Trp Ser Pro 
225                 230                 235                 240 


Val Lys Asn Ile Ser Trp Ile Pro Asp Ser Gln Thr Lys Val Phe Pro 
                245                 250                 255     


Gln Asp Lys Val Ile Leu Val Gly Ser Asp Ile Thr Phe Cys Cys Val 
            260                 265                 270         


Ser Gln Glu Lys Val Leu Ser Ala Leu Ile Gly His Thr Asn Cys Pro 
        275                 280                 285             


Leu Ile His Leu Asp Gly Glu Asn Val Ala Ile Lys Ile Arg Asn Ile 
    290                 295                 300                 


Ser Val Ser Ala Ser Ser Gly Thr Asn Val Val Phe Thr Thr Glu Asp 
305                 310                 315                 320 


Asn Ile Phe Gly Thr Val Ile Phe Ala Gly Tyr Pro Pro Asp Thr Pro 
                325                 330                 335     


Gln Gln Leu Asn Cys Glu Thr His Asp Leu Lys Glu Ile Ile Cys Ser 
            340                 345                 350         


Trp Asn Pro Gly Arg Val Thr Ala Leu Val Gly Pro Arg Ala Thr Ser 
        355                 360                 365             


Tyr Thr Leu Val Glu Ser Phe Ser Gly Lys Tyr Val Arg Leu Lys Arg 
    370                 375                 380                 


Ala Glu Ala Pro Thr Asn Glu Ser Tyr Gln Leu Leu Phe Gln Met Leu 
385                 390                 395                 400 


Pro Asn Gln Glu Ile Tyr Asn Phe Thr Leu Asn Ala His Asn Pro Leu 
                405                 410                 415     


Gly Arg Ser Gln Ser Thr Ile Leu Val Asn Ile Thr Glu Lys Val Tyr 
            420                 425                 430         


Pro His Thr Pro Thr Ser Phe Lys Val Lys Asp Ile Asn Ser Thr Ala 
        435                 440                 445             


Val Lys Leu Ser Trp His Leu Pro Gly Asn Phe Ala Lys Ile Asn Phe 
    450                 455                 460                 


Leu Cys Glu Ile Glu Ile Lys Lys Ser Asn Ser Val Gln Glu Gln Arg 
465                 470                 475                 480 


Asn Val Thr Ile Lys Gly Val Glu Asn Ser Ser Tyr Leu Val Ala Leu 
                485                 490                 495     


Asp Lys Leu Asn Pro Tyr Thr Leu Tyr Thr Phe Arg Ile Arg Cys Ser 
            500                 505                 510         


Thr Glu Thr Phe Trp Lys Trp Ser Lys Trp Ser Asn Lys Lys Gln His 
        515                 520                 525             


Leu Thr Thr Glu Ala Ser Pro Ser Lys Gly Pro Asp Thr Trp Arg Glu 
    530                 535                 540                 


Trp Ser Ser Asp Gly Lys Asn Leu Ile Ile Tyr Trp Lys Pro Leu Pro 
545                 550                 555                 560 


Ile Asn Glu Ala Asn Gly Lys Ile Leu Ser Tyr Asn Val Ser Cys Ser 
                565                 570                 575     


Ser Asp Glu Glu Thr Gln Ser Leu Ser Glu Ile Pro Asp Pro Gln His 
            580                 585                 590         


Lys Ala Glu Ile Arg Leu Asp Lys Asn Asp Tyr Ile Ile Ser Val Val 
        595                 600                 605             


Ala Lys Asn Ser Val Gly Ser Ser Pro Pro Ser Lys Ile Ala Ser Met 
    610                 615                 620                 


Glu Ile Pro Asn Asp Asp Leu Lys Ile Glu Gln Val Val Gly Met Gly 
625                 630                 635                 640 


Lys Gly Ile Leu Leu Thr Trp His Tyr Asp Pro Asn Met Thr Cys Asp 
                645                 650                 655     


Tyr Val Ile Lys Trp Cys Asn Ser Ser Arg Ser Glu Pro Cys Leu Met 
            660                 665                 670         


Asp Trp Arg Lys Val Pro Ser Asn Ser Thr Glu Thr Val Ile Glu Ser 
        675                 680                 685             


Asp Glu Phe Arg Pro Gly Ile Arg Tyr Asn Phe Phe Leu Tyr Gly Cys 
    690                 695                 700                 


Arg Asn Gln Gly Tyr Gln Leu Leu Arg Ser Met Ile Gly Tyr Ile Glu 
705                 710                 715                 720 


Glu Leu Ala Pro Ile Val Ala Pro Asn Phe Thr Val Glu Asp Thr Ser 
                725                 730                 735     


Ala Asp Ser Ile Leu Val Lys Trp Glu Asp Ile Pro Val Glu Glu Leu 
            740                 745                 750         


Arg Gly Phe Leu Arg Gly Tyr Leu Phe Tyr Phe Gly Lys Gly Glu Arg 
        755                 760                 765             


Asp Thr Ser Lys Met Arg Val Leu Glu Ser Gly Arg Ser Asp Ile Lys 
    770                 775                 780                 


Val Lys Asn Ile Thr Asp Ile Ser Gln Lys Thr Leu Arg Ile Ala Asp 
785                 790                 795                 800 


Leu Gln Gly Lys Thr Ser Tyr His Leu Val Leu Arg Ala Tyr Thr Asp 
                805                 810                 815     


Gly Gly Val Gly Pro Glu Lys Ser Met Tyr Val Val Thr Lys Glu Asn 
            820                 825                 830         


Ser Val Gly Leu Ile Ile Ala Ile Leu Ile Pro Val Ala Val Ala Val 
        835                 840                 845             


Ile Val Gly Val Val Thr Ser Ile Leu Cys Tyr Arg Lys Arg Glu Trp 
    850                 855                 860                 


Ile Lys Glu Thr Phe Tyr Pro Asp Ile Pro Asn Pro Glu Asn Cys Lys 
865                 870                 875                 880 


Ala Leu Gln Phe Gln Lys Ser Val Cys Glu Gly Ser Ser Ala Leu Lys 
                885                 890                 895     


Thr Leu Glu Met Asn Pro Cys Thr Pro Asn Asn Val Glu Val Leu Glu 
            900                 905                 910         


Thr Arg Ser Ala Phe Pro Lys Ile Glu Asp Thr Glu Ile Ile Ser Pro 
        915                 920                 925             


Val Ala Glu Arg Pro Glu Asp Arg Ser Asp Ala Glu Pro Glu Asn His 
    930                 935                 940                 


Val Val Val Ser Tyr Cys Pro Pro Ile Ile Glu Glu Glu Ile Pro Asn 
945                 950                 955                 960 


Pro Ala Ala Asp Glu Ala Gly Gly Thr Ala Gln Val Ile Tyr Ile Asp 
                965                 970                 975     


Val Gln Ser Met Tyr Gln Pro Gln Ala Lys Pro Glu Glu Glu Gln Glu 
            980                 985                 990         


Asn Asp Pro Val Gly Gly Ala Gly  Tyr Lys Pro Gln Met  His Leu Pro 
        995                 1000                 1005             


Ile Asn  Ser Thr Val Glu Asp  Ile Ala Ala Glu Glu  Asp Leu Asp 
    1010                 1015                 1020             


Lys Thr  Ala Gly Tyr Arg Pro  Gln Ala Asn Val Asn  Thr Trp Asn 
    1025                 1030                 1035             


Leu Val  Ser Pro Asp Ser Pro  Arg Ser Ile Asp Ser  Asn Ser Glu 
    1040                 1045                 1050             


Ile Val  Ser Phe Gly Ser Pro  Cys Ser Ile Asn Ser  Arg Gln Phe 
    1055                 1060                 1065             


Leu Ile  Pro Pro Lys Asp Glu  Asp Ser Pro Lys Ser  Asn Gly Gly 
    1070                 1075                 1080             


Gly Trp  Ser Phe Thr Asn Phe  Phe Gln Asn Lys Pro  Asn Asp 
    1085                 1090                 1095         


<210>  7861
<211>  1097
<212>  PRT
<213>  Homo Sapiens

<400>  7861

Met Met Asp Ile Tyr Val Cys Leu Lys Arg Pro Ser Trp Met Val Asp 
1               5                   10                  15      


Asn Lys Arg Met Arg Thr Ala Ser Asn Phe Gln Trp Leu Leu Ser Thr 
            20                  25                  30          


Phe Ile Leu Leu Tyr Leu Met Asn Gln Val Asn Ser Gln Lys Lys Gly 
        35                  40                  45              


Ala Pro His Asp Leu Lys Cys Val Thr Asn Asn Leu Gln Val Trp Asn 
    50                  55                  60                  


Cys Ser Trp Lys Ala Pro Ser Gly Thr Gly Arg Gly Thr Asp Tyr Glu 
65                  70                  75                  80  


Val Cys Ile Glu Asn Arg Ser Arg Ser Cys Tyr Gln Leu Glu Lys Thr 
                85                  90                  95      


Ser Ile Lys Ile Pro Ala Leu Ser His Gly Asp Tyr Glu Ile Thr Ile 
            100                 105                 110         


Asn Ser Leu His Asp Phe Gly Ser Ser Thr Ser Lys Phe Thr Leu Asn 
        115                 120                 125             


Glu Gln Asn Val Ser Leu Ile Pro Asp Thr Pro Glu Ile Leu Asn Leu 
    130                 135                 140                 


Ser Ala Asp Phe Ser Thr Ser Thr Leu Tyr Leu Lys Trp Asn Asp Arg 
145                 150                 155                 160 


Gly Ser Val Phe Pro His Arg Ser Asn Val Ile Trp Glu Ile Lys Val 
                165                 170                 175     


Leu Arg Lys Glu Ser Met Glu Leu Val Lys Leu Val Thr His Asn Thr 
            180                 185                 190         


Thr Leu Asn Gly Lys Asp Thr Leu His His Trp Ser Trp Ala Ser Asp 
        195                 200                 205             


Met Pro Leu Glu Cys Ala Ile His Phe Val Glu Ile Arg Cys Tyr Ile 
    210                 215                 220                 


Asp Asn Leu His Phe Ser Gly Leu Glu Glu Trp Ser Asp Trp Ser Pro 
225                 230                 235                 240 


Val Lys Asn Ile Ser Trp Ile Pro Asp Ser Gln Thr Lys Val Phe Pro 
                245                 250                 255     


Gln Asp Lys Val Ile Leu Val Gly Ser Asp Ile Thr Phe Cys Cys Val 
            260                 265                 270         


Ser Gln Glu Lys Val Leu Ser Ala Leu Ile Gly His Thr Asn Cys Pro 
        275                 280                 285             


Leu Ile His Leu Asp Gly Glu Asn Val Ala Ile Lys Ile Arg Asn Ile 
    290                 295                 300                 


Ser Val Ser Ala Ser Ser Gly Thr Asn Val Val Phe Thr Thr Glu Asp 
305                 310                 315                 320 


Asn Ile Phe Gly Thr Val Ile Phe Ala Gly Tyr Pro Pro Asp Thr Pro 
                325                 330                 335     


Gln Gln Leu Asn Cys Glu Thr His Asp Leu Lys Glu Ile Ile Cys Ser 
            340                 345                 350         


Trp Asn Pro Gly Arg Val Thr Ala Leu Val Gly Pro Arg Ala Thr Ser 
        355                 360                 365             


Tyr Thr Leu Val Glu Ser Phe Ser Gly Lys Tyr Val Arg Leu Lys Arg 
    370                 375                 380                 


Ala Glu Ala Pro Thr Asn Glu Ser Tyr Gln Leu Leu Phe Gln Met Leu 
385                 390                 395                 400 


Pro Asn Gln Glu Ile Tyr Asn Phe Thr Leu Asn Ala His Asn Pro Leu 
                405                 410                 415     


Gly Arg Ser Gln Ser Thr Ile Leu Val Asn Ile Thr Glu Lys Val Tyr 
            420                 425                 430         


Pro His Thr Pro Thr Ser Phe Lys Val Lys Asp Ile Asn Ser Thr Ala 
        435                 440                 445             


Val Lys Leu Ser Trp His Leu Pro Gly Asn Phe Ala Lys Ile Asn Phe 
    450                 455                 460                 


Leu Cys Glu Ile Glu Ile Lys Lys Ser Asn Ser Val Gln Glu Gln Arg 
465                 470                 475                 480 


Asn Val Thr Ile Lys Gly Val Glu Asn Ser Ser Tyr Leu Val Ala Leu 
                485                 490                 495     


Asp Lys Leu Asn Pro Tyr Thr Leu Tyr Thr Phe Arg Ile Arg Cys Ser 
            500                 505                 510         


Thr Glu Thr Phe Trp Lys Trp Ser Lys Trp Ser Asn Lys Lys Gln His 
        515                 520                 525             


Leu Thr Thr Glu Ala Ser Pro Ser Lys Gly Pro Asp Thr Trp Arg Glu 
    530                 535                 540                 


Trp Ser Ser Asp Gly Lys Asn Leu Ile Ile Tyr Trp Lys Pro Leu Pro 
545                 550                 555                 560 


Ile Asn Glu Ala Asn Gly Lys Ile Leu Ser Tyr Asn Val Ser Cys Ser 
                565                 570                 575     


Ser Asp Glu Glu Thr Gln Ser Leu Ser Glu Ile Pro Asp Pro Gln His 
            580                 585                 590         


Lys Ala Glu Ile Arg Leu Asp Lys Asn Asp Tyr Ile Ile Ser Val Val 
        595                 600                 605             


Ala Lys Asn Ser Val Gly Ser Ser Pro Pro Ser Lys Ile Ala Ser Met 
    610                 615                 620                 


Glu Ile Pro Asn Asp Asp Leu Lys Ile Glu Gln Val Val Gly Met Gly 
625                 630                 635                 640 


Lys Gly Ile Leu Leu Thr Trp His Tyr Asp Pro Asn Met Thr Cys Asp 
                645                 650                 655     


Tyr Val Ile Lys Trp Cys Asn Ser Ser Arg Ser Glu Pro Cys Leu Met 
            660                 665                 670         


Asp Trp Arg Lys Val Pro Ser Asn Ser Thr Glu Thr Val Ile Glu Ser 
        675                 680                 685             


Asp Glu Phe Arg Pro Gly Ile Arg Tyr Asn Phe Phe Leu Tyr Gly Cys 
    690                 695                 700                 


Arg Asn Gln Gly Tyr Gln Leu Leu Arg Ser Met Ile Gly Tyr Ile Glu 
705                 710                 715                 720 


Glu Leu Ala Pro Ile Val Ala Pro Asn Phe Thr Val Glu Asp Thr Ser 
                725                 730                 735     


Ala Asp Ser Ile Leu Val Lys Trp Glu Asp Ile Pro Val Glu Glu Leu 
            740                 745                 750         


Arg Gly Phe Leu Arg Gly Tyr Leu Phe Tyr Phe Gly Lys Gly Glu Arg 
        755                 760                 765             


Asp Thr Ser Lys Met Arg Val Leu Glu Ser Gly Arg Ser Asp Ile Lys 
    770                 775                 780                 


Val Lys Asn Ile Thr Asp Ile Ser Gln Lys Thr Leu Arg Ile Ala Asp 
785                 790                 795                 800 


Leu Gln Gly Lys Thr Ser Tyr His Leu Val Leu Arg Ala Tyr Thr Asp 
                805                 810                 815     


Gly Gly Val Gly Pro Glu Lys Ser Met Tyr Val Val Thr Lys Glu Asn 
            820                 825                 830         


Ser Val Gly Leu Ile Ile Ala Ile Leu Ile Pro Val Ala Val Ala Val 
        835                 840                 845             


Ile Val Gly Val Val Thr Ser Ile Leu Cys Tyr Arg Lys Arg Glu Trp 
    850                 855                 860                 


Ile Lys Glu Thr Phe Tyr Pro Asp Ile Pro Asn Pro Glu Asn Cys Lys 
865                 870                 875                 880 


Ala Leu Gln Phe Gln Lys Ser Val Cys Glu Gly Ser Ser Ala Leu Lys 
                885                 890                 895     


Thr Leu Glu Met Asn Pro Cys Thr Pro Asn Asn Val Glu Val Leu Glu 
            900                 905                 910         


Thr Arg Ser Ala Phe Pro Lys Ile Glu Asp Thr Glu Ile Ile Ser Pro 
        915                 920                 925             


Val Ala Glu Arg Pro Glu Asp Arg Ser Asp Ala Glu Pro Glu Asn His 
    930                 935                 940                 


Val Val Val Ser Tyr Cys Pro Pro Ile Ile Glu Glu Glu Ile Pro Asn 
945                 950                 955                 960 


Pro Ala Ala Asp Glu Ala Gly Gly Thr Ala Gln Val Ile Tyr Ile Asp 
                965                 970                 975     


Val Gln Ser Met Tyr Gln Pro Gln Ala Lys Pro Glu Glu Glu Gln Glu 
            980                 985                 990         


Asn Asp Pro Val Gly Gly Ala Gly  Tyr Lys Pro Gln Met  His Leu Pro 
        995                 1000                 1005             


Ile Asn  Ser Thr Val Glu Asp  Ile Ala Ala Glu Glu  Asp Leu Asp 
    1010                 1015                 1020             


Lys Thr  Ala Gly Tyr Arg Pro  Gln Ala Asn Val Asn  Thr Trp Asn 
    1025                 1030                 1035             


Leu Val  Ser Pro Asp Ser Pro  Arg Ser Ile Asp Ser  Asn Ser Glu 
    1040                 1045                 1050             


Ile Val  Ser Phe Gly Ser Pro  Cys Ser Ile Asn Ser  Arg Gln Phe 
    1055                 1060                 1065             


Leu Ile  Pro Pro Lys Asp Glu  Asp Ser Pro Lys Ser  Asn Gly Gly 
    1070                 1075                 1080             


Gly Trp  Ser Phe Thr Asn Phe  Phe Gln Asn Lys Pro  Asn Asp 
    1085                 1090                 1095         


<210>  7862
<211>  66
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7862

Xaa Trp Ser Asn Lys Lys Gln His Leu Thr Thr Glu Ala Ser Pro Ser 
1               5                   10                  15      


Lys Gly Pro Asp Thr Trp Arg Glu Trp Ser Ser Asp Gly Lys Asn Leu 
            20                  25                  30          


Ile Ile Tyr Trp Lys Met Arg Lys His Ser Pro Phe Leu Lys Ser Leu 
        35                  40                  45              


Ile Leu Ser Thr Lys Gln Arg Tyr Asp Leu Ile Arg Met Thr Thr Ser 
    50                  55                  60                  


Ser Ala 
65      


<210>  7863
<211>  289
<212>  PRT
<213>  Homo Sapiens

<400>  7863

Met Thr Pro Ile Val Thr Val Leu Ile Cys Leu Arg Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Val Gln Ala Gly Thr Leu Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Trp 
        35                  40                  45              


Cys Gln Gly Ile Leu Glu Thr Gln Glu Tyr Arg Leu Tyr Arg Glu Lys 
    50                  55                  60                  


Lys Thr Ala Pro Trp Ile Thr Arg Ile Pro Gln Glu Ile Val Lys Lys 
65                  70                  75                  80  


Gly Gln Phe Pro Ile Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr 
                85                  90                  95      


Arg Cys Phe Tyr Gly Ser His Thr Ala Gly Trp Ser Glu Pro Ser Asp 
            100                 105                 110         


Pro Leu Glu Leu Val Val Thr Gly Ala Tyr Ile Lys Pro Thr Leu Ser 
        115                 120                 125             


Ala Leu Pro Ser Pro Val Val Thr Ser Gly Gly Asn Val Thr Leu His 
    130                 135                 140                 


Cys Val Ser Gln Val Ala Phe Gly Ser Phe Ile Leu Cys Lys Glu Gly 
145                 150                 155                 160 


Glu Asp Glu His Pro Gln Cys Leu Asn Ser Gln Pro Arg Thr His Gly 
                165                 170                 175     


Trp Ser Arg Ala Ile Phe Ser Val Gly Pro Val Ser Pro Ser Arg Arg 
            180                 185                 190         


Trp Ser Tyr Arg Cys Tyr Ala Tyr Asp Ser Asn Ser Pro His Val Trp 
        195                 200                 205             


Ser Leu Pro Ser Asp Leu Leu Glu Leu Leu Val Leu Gly Ala Ala Glu 
    210                 215                 220                 


Thr Leu Ser Pro Pro Gln Asn Lys Ser Asp Ser Lys Ala Gly Ala Ala 
225                 230                 235                 240 


Asn Thr Leu Ser Pro Ser Gln Asn Lys Thr Ala Ser His Pro Gln Asp 
                245                 250                 255     


Tyr Thr Val Glu Asn Leu Ile Arg Met Gly Ile Ala Gly Leu Val Leu 
            260                 265                 270         


Val Val Leu Gly Ile Leu Leu Phe Glu Ala Gln His Ser Gln Arg Ser 
        275                 280                 285             


Leu 
    


<210>  7864
<211>  489
<212>  PRT
<213>  Homo Sapiens

<400>  7864

Met Thr Pro Ile Val Thr Val Leu Ile Cys Leu Arg Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Val Gln Ala Gly Thr Leu Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Trp 
        35                  40                  45              


Cys Gln Gly Ile Leu Glu Thr Gln Glu Tyr Arg Leu Tyr Arg Glu Lys 
    50                  55                  60                  


Lys Thr Ala Pro Trp Ile Thr Arg Ile Pro Gln Glu Ile Val Lys Lys 
65                  70                  75                  80  


Gly Gln Phe Pro Ile Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr 
                85                  90                  95      


Arg Cys Phe Tyr Gly Ser His Thr Ala Gly Trp Ser Glu Pro Ser Asp 
            100                 105                 110         


Pro Leu Glu Leu Val Val Thr Gly Ala Tyr Ile Lys Pro Thr Leu Ser 
        115                 120                 125             


Ala Leu Pro Ser Pro Val Val Thr Ser Gly Gly Asn Val Thr Leu His 
    130                 135                 140                 


Cys Val Ser Gln Val Ala Phe Gly Ser Phe Ile Leu Cys Lys Glu Gly 
145                 150                 155                 160 


Glu Asp Glu His Pro Gln Cys Leu Asn Ser Gln Pro Arg Thr His Gly 
                165                 170                 175     


Trp Ser Arg Ala Ile Phe Ser Val Gly Pro Val Ser Pro Ser Arg Arg 
            180                 185                 190         


Trp Ser Tyr Arg Cys Tyr Ala Tyr Asp Ser Asn Ser Pro His Val Trp 
        195                 200                 205             


Ser Leu Pro Ser Asp Leu Leu Glu Leu Leu Val Leu Gly Val Ser Lys 
    210                 215                 220                 


Lys Pro Ser Leu Ser Val Gln Pro Gly Pro Ile Val Ala Pro Gly Glu 
225                 230                 235                 240 


Ser Leu Thr Leu Gln Cys Val Ser Asp Val Ser Tyr Asp Arg Phe Val 
                245                 250                 255     


Leu Tyr Lys Glu Gly Glu Arg Asp Phe Leu Gln Leu Pro Gly Pro Gln 
            260                 265                 270         


Pro Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser 
        275                 280                 285             


Arg Ser Tyr Gly Gly Gln Tyr Arg Cys Ser Gly Ala Tyr Asn Leu Ser 
    290                 295                 300                 


Ser Glu Trp Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Ala Gly 
305                 310                 315                 320 


Gln Phe Arg Gly Arg Pro Phe Ile Ser Val His Pro Gly Pro Thr Val 
                325                 330                 335     


Ala Ser Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Trp Gly Pro Phe 
            340                 345                 350         


His Thr Phe Leu Leu Thr Lys Ala Gly Ala Ala Asp Ala Pro Leu Arg 
        355                 360                 365             


Leu Arg Ser Ile His Glu Tyr Pro Lys Tyr Gln Ala Glu Phe Pro Met 
    370                 375                 380                 


Ser Pro Val Thr Ser Ala His Ser Gly Thr Tyr Arg Cys Tyr Gly Ser 
385                 390                 395                 400 


Leu Ser Ser Asn Pro Tyr Leu Leu Ser His Pro Ser Asp Ser Leu Glu 
                405                 410                 415     


Leu Met Val Ser Gly Ala Ala Glu Thr Leu Ser Pro Pro Gln Asn Lys 
            420                 425                 430         


Ser Asp Ser Lys Ala Gly Ala Ala Asn Thr Leu Ser Pro Ser Gln Asn 
        435                 440                 445             


Lys Thr Ala Ser His Pro Gln Asp Tyr Thr Val Glu Asn Leu Ile Arg 
    450                 455                 460                 


Met Gly Ile Ala Gly Leu Val Leu Val Val Leu Gly Ile Leu Leu Phe 
465                 470                 475                 480 


Glu Ala Gln His Ser Gln Arg Ser Leu 
                485                 


<210>  7865
<211>  454
<212>  PRT
<213>  Homo Sapiens

<400>  7865

Met Thr Pro Ile Leu Thr Val Leu Ile Cys Leu Gly His Leu Pro Lys 
1               5                   10                  15      


Pro Thr Leu Trp Ala Glu Pro Gly Ser Val Ile Ile Gln Gly Ser Pro 
            20                  25                  30          


Val Thr Leu Arg Cys Gln Gly Ser Leu Gln Ala Glu Glu Tyr His Leu 
        35                  40                  45              


Tyr Arg Glu Asn Lys Ser Ala Ser Trp Val Arg Arg Ile Gln Glu Pro 
    50                  55                  60                  


Gly Lys Asn Gly Gln Phe Pro Ile Pro Ser Ile Thr Trp Glu His Ala 
65                  70                  75                  80  


Gly Arg Tyr His Cys Gln Tyr Tyr Ser His Asn His Ser Ser Glu Tyr 
                85                  90                  95      


Ser Asp Pro Leu Glu Leu Val Val Thr Gly Ala Tyr Ser Lys Pro Thr 
            100                 105                 110         


Leu Ser Ala Leu Pro Ser Pro Val Val Thr Ser Gly Gly Asn Val Thr 
        115                 120                 125             


Leu Gln Cys Val Ser Gln Val Ala Phe Asp Gly Phe Ile Leu Cys Lys 
    130                 135                 140                 


Glu Gly Glu Asp Glu His Pro Gln Arg Leu Asn Ser His Ser His Ala 
145                 150                 155                 160 


Arg Gly Trp Ser Trp Ala Ile Phe Ser Val Gly Pro Val Ser Pro Ser 
                165                 170                 175     


Arg Arg Trp Ser Tyr Arg Cys Tyr Ala Tyr Asp Ser Asn Ser Pro Tyr 
            180                 185                 190         


Val Trp Ser Leu Pro Ser Asp Leu Leu Glu Leu Leu Val Pro Gly Val 
        195                 200                 205             


Ser Lys Lys Pro Ser Leu Ser Val Gln Pro Gly Pro Met Val Ala Pro 
    210                 215                 220                 


Gly Glu Ser Leu Thr Leu Gln Cys Val Ser Asp Val Gly Tyr Asp Arg 
225                 230                 235                 240 


Phe Val Leu Tyr Lys Glu Gly Glu Arg Asp Phe Leu Gln Arg Pro Gly 
                245                 250                 255     


Trp Gln Pro Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro 
            260                 265                 270         


Val Ser Pro Ser His Gly Gly Gln Tyr Arg Cys Tyr Ser Ala His Asn 
        275                 280                 285             


Leu Ser Ser Glu Trp Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile 
    290                 295                 300                 


Thr Gly Gln Phe Tyr Asp Arg Pro Ser Leu Ser Val Gln Pro Val Pro 
305                 310                 315                 320 


Thr Val Ala Pro Gly Lys Asn Val Thr Leu Leu Cys Gln Ser Arg Gly 
                325                 330                 335     


Gln Phe His Thr Phe Leu Leu Thr Lys Glu Gly Ala Gly His Pro Pro 
            340                 345                 350         


Leu His Leu Arg Ser Glu His Gln Ala Gln Gln Asn Gln Ala Glu Phe 
        355                 360                 365             


Arg Met Gly Pro Val Thr Ser Ala His Val Gly Thr Tyr Arg Cys Tyr 
    370                 375                 380                 


Ser Ser Leu Ser Ser Asn Pro Tyr Leu Leu Ser Leu Pro Ser Asp Pro 
385                 390                 395                 400 


Leu Glu Leu Val Val Ser Ala Ser Leu Gly Gln His Pro Gln Asp Tyr 
                405                 410                 415     


Thr Val Glu Asn Leu Ile Arg Met Gly Val Ala Gly Leu Val Leu Val 
            420                 425                 430         


Val Leu Gly Ile Leu Leu Phe Glu Ala Gln His Ser Gln Arg Ser Leu 
        435                 440                 445             


Gln Asp Ala Ala Gly Arg 
    450                 


<210>  7866
<211>  203
<212>  PRT
<213>  Homo Sapiens

<400>  7866

Met Thr Pro Ile Leu Thr Val Leu Ile Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Val Gln Ala Gly His Leu Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Ile Gln Gly Ser Pro Val Thr Leu Arg 
        35                  40                  45              


Cys Gln Gly Ser Leu Gln Ala Glu Glu Tyr His Leu Tyr Arg Glu Asn 
    50                  55                  60                  


Lys Ser Ala Ser Trp Val Arg Arg Ile Gln Glu Pro Gly Lys Asn Gly 
65                  70                  75                  80  


Gln Phe Pro Ile Pro Ser Ile Thr Trp Glu His Ala Gly Arg Tyr His 
                85                  90                  95      


Cys Gln Tyr Tyr Ser His Asn His Ser Ser Glu His Gln Ala Gln Gln 
            100                 105                 110         


Asn Gln Ala Glu Phe Arg Met Gly Pro Val Thr Ser Ala His Val Gly 
        115                 120                 125             


Thr Tyr Arg Cys Tyr Ser Ser Leu Ser Ser Asn Pro Tyr Leu Leu Ser 
    130                 135                 140                 


Leu Pro Ser Asp Pro Leu Glu Leu Val Val Ser Ala Ser Leu Gly Gln 
145                 150                 155                 160 


His Pro Gln Asp Tyr Thr Val Glu Asn Leu Ile Arg Met Gly Val Ala 
                165                 170                 175     


Gly Leu Val Leu Val Val Leu Gly Ile Leu Leu Phe Glu Ala Gln His 
            180                 185                 190         


Ser Gln Arg Ser Leu Gln Asp Ala Ala Gly Arg 
        195                 200             


<210>  7867
<211>  466
<212>  PRT
<213>  Homo Sapiens

<400>  7867

Met Thr Pro Ile Leu Thr Val Leu Ile Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Val Gln Ala Gly His Leu Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Ile Gln Gly Ser Pro Val Thr Leu Arg 
        35                  40                  45              


Cys Gln Gly Ser Leu Gln Ala Glu Glu Tyr His Leu Tyr Arg Glu Asn 
    50                  55                  60                  


Lys Ser Ala Ser Trp Val Arg Arg Ile Gln Glu Pro Gly Lys Asn Gly 
65                  70                  75                  80  


Gln Phe Pro Ile Pro Ser Ile Thr Trp Glu His Ala Gly Arg Tyr His 
                85                  90                  95      


Cys Gln Tyr Tyr Ser His Asn His Ser Ser Glu Tyr Ser Asp Pro Leu 
            100                 105                 110         


Glu Leu Val Val Thr Gly Ala Tyr Ser Lys Pro Thr Leu Ser Ala Leu 
        115                 120                 125             


Pro Ser Pro Val Val Thr Ser Gly Gly Asn Val Thr Leu Gln Cys Val 
    130                 135                 140                 


Ser Gln Val Ala Phe Asp Gly Phe Ile Leu Cys Lys Glu Gly Glu Asp 
145                 150                 155                 160 


Glu His Pro Gln Arg Leu Asn Ser His Ser His Ala Arg Gly Trp Ser 
                165                 170                 175     


Trp Ala Ile Phe Ser Val Gly Pro Val Ser Pro Ser Arg Arg Trp Ser 
            180                 185                 190         


Tyr Arg Cys Tyr Ala Tyr Asp Ser Asn Ser Pro Tyr Val Trp Ser Leu 
        195                 200                 205             


Pro Ser Asp Leu Leu Glu Leu Leu Val Pro Gly Val Ser Lys Lys Pro 
    210                 215                 220                 


Ser Leu Ser Val Gln Pro Gly Pro Met Val Ala Pro Gly Glu Ser Leu 
225                 230                 235                 240 


Thr Leu Gln Cys Val Ser Asp Val Gly Tyr Asp Arg Phe Val Leu Tyr 
                245                 250                 255     


Lys Glu Gly Glu Arg Asp Phe Leu Gln Arg Pro Gly Trp Gln Pro Gln 
            260                 265                 270         


Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Pro Ser 
        275                 280                 285             


His Gly Gly Gln Tyr Arg Cys Tyr Ser Ala His Asn Leu Ser Ser Glu 
    290                 295                 300                 


Trp Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Thr Gly Gln Phe 
305                 310                 315                 320 


Tyr Asp Arg Pro Ser Leu Ser Val Gln Pro Val Pro Thr Val Ala Pro 
                325                 330                 335     


Gly Lys Asn Val Thr Leu Leu Cys Gln Ser Arg Gly Gln Phe His Thr 
            340                 345                 350         


Phe Leu Leu Thr Lys Glu Gly Ala Gly His Pro Pro Leu His Leu Arg 
        355                 360                 365             


Ser Glu His Gln Ala Gln Gln Asn Gln Ala Glu Phe Arg Met Gly Pro 
    370                 375                 380                 


Val Thr Ser Ala His Val Gly Thr Tyr Arg Cys Tyr Ser Ser Leu Ser 
385                 390                 395                 400 


Ser Asn Pro Tyr Leu Leu Ser Leu Pro Ser Asp Pro Leu Glu Leu Val 
                405                 410                 415     


Val Ser Ala Ser Leu Gly Gln His Pro Gln Asp Tyr Thr Val Glu Asn 
            420                 425                 430         


Leu Ile Arg Met Gly Val Ala Gly Leu Val Leu Val Val Leu Gly Ile 
        435                 440                 445             


Leu Leu Phe Glu Ala Gln His Ser Gln Arg Ser Leu Gln Asp Ala Ala 
    450                 455                 460                 


Gly Arg 
465     


<210>  7868
<211>  483
<212>  PRT
<213>  Homo Sapiens

<400>  7868

Met Thr Pro Ile Leu Thr Val Leu Ile Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Val Gln Ala Gly His Leu Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Ile Gln Gly Ser Pro Val Thr Leu Arg 
        35                  40                  45              


Cys Gln Gly Ser Leu Gln Ala Glu Glu Tyr His Leu Tyr Arg Glu Asn 
    50                  55                  60                  


Lys Ser Ala Ser Trp Val Arg Arg Ile Gln Glu Pro Gly Lys Asn Gly 
65                  70                  75                  80  


Gln Phe Pro Ile Pro Ser Ile Thr Trp Glu His Ala Gly Arg Tyr His 
                85                  90                  95      


Cys Gln Tyr Tyr Ser His Asn His Ser Ser Glu Tyr Ser Asp Pro Leu 
            100                 105                 110         


Glu Leu Val Val Thr Gly Ala Tyr Ser Lys Pro Thr Leu Ser Ala Leu 
        115                 120                 125             


Pro Ser Pro Val Val Thr Ser Gly Gly Asn Val Thr Leu Gln Cys Val 
    130                 135                 140                 


Ser Gln Val Ala Phe Asp Gly Phe Ile Leu Cys Lys Glu Gly Glu Asp 
145                 150                 155                 160 


Glu His Pro Gln Arg Leu Asn Ser His Ser His Ala Arg Gly Trp Ser 
                165                 170                 175     


Trp Ala Ile Phe Ser Val Gly Pro Val Ser Pro Ser Arg Arg Trp Ser 
            180                 185                 190         


Tyr Arg Cys Tyr Ala Tyr Asp Ser Asn Ser Pro Tyr Val Trp Ser Leu 
        195                 200                 205             


Pro Ser Asp Leu Leu Glu Leu Leu Val Pro Gly Val Ser Lys Lys Pro 
    210                 215                 220                 


Ser Leu Ser Val Gln Pro Gly Pro Met Val Ala Pro Gly Glu Ser Leu 
225                 230                 235                 240 


Thr Leu Gln Cys Val Ser Asp Val Gly Tyr Asp Arg Phe Val Leu Tyr 
                245                 250                 255     


Lys Glu Gly Glu Arg Asp Phe Leu Gln Arg Pro Gly Trp Gln Pro Gln 
            260                 265                 270         


Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Pro Ser 
        275                 280                 285             


His Gly Gly Gln Tyr Arg Cys Tyr Ser Ala His Asn Leu Ser Ser Glu 
    290                 295                 300                 


Trp Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Thr Gly Gln Phe 
305                 310                 315                 320 


Tyr Asp Arg Pro Ser Leu Ser Val Gln Pro Val Pro Thr Val Ala Pro 
                325                 330                 335     


Gly Lys Asn Val Thr Leu Leu Cys Gln Ser Arg Gly Gln Phe His Thr 
            340                 345                 350         


Phe Leu Leu Thr Lys Glu Gly Ala Gly His Pro Pro Leu His Leu Arg 
        355                 360                 365             


Ser Glu His Gln Ala Gln Gln Asn Gln Ala Glu Phe Arg Met Gly Pro 
    370                 375                 380                 


Val Thr Ser Ala His Val Gly Thr Tyr Arg Cys Tyr Ser Ser Leu Ser 
385                 390                 395                 400 


Ser Asn Pro Tyr Leu Leu Ser Leu Pro Ser Asp Pro Leu Glu Leu Val 
                405                 410                 415     


Val Ser Glu Ala Ala Glu Thr Leu Ser Pro Ser Gln Asn Lys Thr Asp 
            420                 425                 430         


Ser Thr Thr Thr Ser Leu Gly Gln His Pro Gln Asp Tyr Thr Val Glu 
        435                 440                 445             


Asn Leu Ile Arg Met Gly Val Ala Gly Leu Val Leu Val Val Leu Gly 
    450                 455                 460                 


Ile Leu Leu Phe Glu Ala Gln His Ser Gln Arg Ser Leu Gln Asp Ala 
465                 470                 475                 480 


Ala Gly Arg 
            


<210>  7869
<211>  483
<212>  PRT
<213>  Homo Sapiens

<400>  7869

Met Thr Pro Ile Leu Thr Val Leu Ile Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Val Gln Ala Gly His Leu Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Ile Gln Gly Ser Pro Val Thr Leu Arg 
        35                  40                  45              


Cys Gln Gly Ser Leu Gln Ala Glu Glu Tyr His Leu Tyr Arg Glu Asn 
    50                  55                  60                  


Lys Ser Ala Ser Trp Val Arg Arg Ile Gln Glu Pro Gly Lys Asn Gly 
65                  70                  75                  80  


Gln Phe Pro Ile Pro Ser Ile Thr Trp Glu His Ala Gly Arg Tyr His 
                85                  90                  95      


Cys Gln Tyr Tyr Ser His Asn His Ser Ser Glu Tyr Ser Asp Pro Leu 
            100                 105                 110         


Glu Leu Val Val Thr Gly Ala Tyr Ser Lys Pro Thr Leu Ser Ala Leu 
        115                 120                 125             


Pro Ser Pro Val Val Thr Ser Gly Gly Asn Val Thr Leu Gln Cys Val 
    130                 135                 140                 


Ser Gln Val Ala Phe Asp Gly Phe Ile Leu Cys Lys Glu Gly Glu Asp 
145                 150                 155                 160 


Glu His Pro Gln Arg Leu Asn Ser His Ser His Ala Arg Gly Trp Ser 
                165                 170                 175     


Trp Ala Ile Phe Ser Val Gly Pro Val Ser Pro Ser Arg Arg Trp Ser 
            180                 185                 190         


Tyr Arg Cys Tyr Ala Tyr Asp Ser Asn Ser Pro Tyr Val Trp Ser Leu 
        195                 200                 205             


Pro Ser Asp Leu Leu Glu Leu Leu Val Pro Gly Val Ser Lys Lys Pro 
    210                 215                 220                 


Ser Leu Ser Val Gln Pro Gly Pro Met Val Ala Pro Gly Glu Ser Leu 
225                 230                 235                 240 


Thr Leu Gln Cys Val Ser Asp Val Gly Tyr Asp Arg Phe Val Leu Tyr 
                245                 250                 255     


Lys Glu Gly Glu Arg Asp Phe Leu Gln Arg Pro Gly Trp Gln Pro Gln 
            260                 265                 270         


Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Pro Ser 
        275                 280                 285             


His Gly Gly Gln Tyr Arg Cys Tyr Ser Ala His Asn Leu Ser Ser Glu 
    290                 295                 300                 


Trp Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Thr Gly Gln Phe 
305                 310                 315                 320 


Tyr Asp Arg Pro Ser Leu Ser Val Gln Pro Val Pro Thr Val Ala Pro 
                325                 330                 335     


Gly Lys Asn Val Thr Leu Leu Cys Gln Ser Arg Gly Gln Phe His Thr 
            340                 345                 350         


Phe Leu Leu Thr Lys Glu Gly Ala Gly His Pro Pro Leu His Leu Arg 
        355                 360                 365             


Ser Glu His Gln Ala Gln Gln Asn Gln Ala Glu Phe Arg Met Gly Pro 
    370                 375                 380                 


Val Thr Ser Ala His Val Gly Thr Tyr Arg Cys Tyr Ser Ser Leu Ser 
385                 390                 395                 400 


Ser Asn Pro Tyr Leu Leu Ser Leu Pro Ser Asp Pro Leu Glu Leu Val 
                405                 410                 415     


Val Ser Glu Ala Ala Glu Thr Leu Ser Pro Ser Gln Asn Lys Thr Asp 
            420                 425                 430         


Ser Thr Thr Thr Ser Leu Gly Gln His Pro Gln Asp Tyr Thr Val Glu 
        435                 440                 445             


Asn Leu Ile Arg Met Gly Val Ala Gly Leu Val Leu Val Val Leu Gly 
    450                 455                 460                 


Ile Leu Leu Phe Glu Ala Gln His Ser Gln Arg Ser Leu Gln Asp Ala 
465                 470                 475                 480 


Ala Gly Arg 
            


<210>  7870
<211>  327
<212>  PRT
<213>  Homo Sapiens

<400>  7870

Met Thr Pro Ile Leu Thr Val Leu Ile Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Val Gln Ala Gly His Leu Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Ile Gln Gly Ser Pro Val Thr Leu Arg 
        35                  40                  45              


Cys Gln Gly Ser Leu Gln Ala Glu Glu Tyr His Leu Tyr Arg Glu Asn 
    50                  55                  60                  


Lys Ser Ala Ser Trp Val Arg Arg Ile Gln Glu Pro Gly Lys Asn Gly 
65                  70                  75                  80  


Gln Phe Pro Ile Pro Ser Ile Thr Trp Glu His Ala Gly Arg Tyr His 
                85                  90                  95      


Cys Gln Tyr Tyr Ser His Asn His Ser Ser Glu Tyr Ser Asp Pro Leu 
            100                 105                 110         


Glu Leu Val Val Thr Gly Ala Tyr Ser Lys Pro Thr Leu Ser Ala Leu 
        115                 120                 125             


Pro Ser Pro Val Val Thr Ser Gly Gly Asn Val Thr Leu Gln Cys Val 
    130                 135                 140                 


Ser Gln Val Ala Phe Asp Gly Phe Ile Leu Cys Lys Glu Gly Glu Asp 
145                 150                 155                 160 


Glu His Pro Gln Arg Leu Asn Ser His Ser His Ala Arg Gly Trp Ser 
                165                 170                 175     


Trp Ala Ile Phe Ser Val Gly Pro Val Ser Pro Ser Arg Arg Trp Ser 
            180                 185                 190         


Tyr Arg Cys Tyr Ala Tyr Asp Ser Asn Ser Pro Tyr Val Trp Ser Leu 
        195                 200                 205             


Pro Ser Asp Leu Leu Glu Leu Leu Val Pro Gly Val Ser Lys Lys Pro 
    210                 215                 220                 


Ser Leu Ser Val Gln Pro Gly Pro Met Val Ala Pro Gly Glu Ser Leu 
225                 230                 235                 240 


Thr Leu Gln Cys Val Ser Asp Val Gly Tyr Asp Arg Phe Val Leu Tyr 
                245                 250                 255     


Lys Glu Gly Glu Arg Asp Phe Leu Gln Arg Pro Gly Trp Gln Pro Gln 
            260                 265                 270         


Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Pro Ser 
        275                 280                 285             


His Gly Gly Gln Tyr Arg Cys Tyr Ser Ala His Asn Leu Ser Ser Glu 
    290                 295                 300                 


Trp Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Thr Gly Gln Phe 
305                 310                 315                 320 


Tyr Asp Arg Pro Ser Leu Ser 
                325         


<210>  7871
<211>  85
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7871

Xaa Ser Leu Pro Ser Asp Pro Leu Glu Leu Val Val Ser Glu Pro Leu 
1               5                   10                  15      


Ser Ile Ser Pro Ser Pro Thr Pro Ala Gly Ser Leu Gly His Leu Lys 
            20                  25                  30          


Thr Arg Glu Glu Ala Ala Trp Ala Ser Val Gly Ser Asp Cys Asp Glu 
        35                  40                  45              


Ala Gly Val His Pro Arg Cys Ala Pro Leu Glu Arg Ser Thr Pro Ala 
    50                  55                  60                  


Val Gly Ala Ala His Thr Ala Pro Pro Val Leu Thr Trp Arg Pro Leu 
65                  70                  75                  80  


Cys Ser Gly His Pro 
                85  


<210>  7872
<211>  158
<212>  PRT
<213>  Homo Sapiens

<400>  7872

Met Thr Pro Ala Leu Thr Ala Leu Leu Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr Arg Met Gln Ala Gly Pro Phe Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Ser Trp Gly Ser Pro Val Thr Ile Trp 
        35                  40                  45              


Cys Gln Gly Ser Leu Glu Ala Gln Glu Tyr Gln Leu Asp Lys Glu Gly 
    50                  55                  60                  


Ser Pro Glu Pro Trp Asp Arg Asn Asn Pro Leu Glu Pro Lys Asn Lys 
65                  70                  75                  80  


Ala Arg Phe Ser Ile Pro Ser Met Thr Gln His His Ala Gly Arg Tyr 
                85                  90                  95      


Arg Cys His Tyr Tyr Ser Ser Ala Gly Trp Ser Glu Pro Ser Asp Pro 
            100                 105                 110         


Leu Glu Leu Val Met Thr Gly Phe Tyr Asn Lys Pro Thr Leu Ser Ala 
        115                 120                 125             


Leu Pro Ser Pro Val Val Ala Ser Gly Gly Asn Met Thr Leu Arg Cys 
    130                 135                 140                 


Gly Ser Gln Lys Gly Tyr His His Phe Val Leu Met Lys Glu 
145                 150                 155             


<210>  7873
<211>  632
<212>  PRT
<213>  Homo Sapiens

<400>  7873

Met Thr Pro Ala Leu Thr Ala Leu Leu Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr Arg Met Gln Ala Gly Pro Phe Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Ser Trp Gly Ser Pro Val Thr Ile Trp 
        35                  40                  45              


Cys Gln Gly Ser Leu Glu Ala Gln Glu Tyr Gln Leu Asp Lys Glu Gly 
    50                  55                  60                  


Ser Pro Glu Pro Trp Asp Arg Asn Asn Pro Leu Glu Pro Lys Asn Lys 
65                  70                  75                  80  


Ala Arg Phe Ser Ile Pro Ser Met Thr Gln His His Ala Gly Arg Tyr 
                85                  90                  95      


Arg Cys His Tyr Tyr Ser Ser Ala Gly Trp Ser Glu Pro Ser Asp Pro 
            100                 105                 110         


Leu Glu Leu Val Met Thr Gly Phe Tyr Asn Lys Pro Thr Leu Ser Ala 
        115                 120                 125             


Leu Pro Ser Pro Val Val Ala Ser Gly Gly Asn Met Thr Leu Arg Cys 
    130                 135                 140                 


Gly Ser Gln Lys Gly Tyr His His Phe Val Leu Met Lys Glu Gly Glu 
145                 150                 155                 160 


His Gln Leu Pro Arg Thr Leu Asp Ser Gln Gln Leu His Ser Gly Gly 
                165                 170                 175     


Phe Gln Ala Leu Phe Pro Val Gly Pro Val Thr Pro Ser His Arg Trp 
            180                 185                 190         


Arg Phe Thr Cys Tyr Tyr Tyr Tyr Thr Asn Thr Pro Trp Val Trp Ser 
        195                 200                 205             


His Pro Ser Asp Pro Leu Glu Ile Leu Pro Ser Gly Val Ser Arg Lys 
    210                 215                 220                 


Pro Ser Leu Leu Thr Leu Gln Gly Pro Val Leu Ala Pro Gly Gln Ser 
225                 230                 235                 240 


Leu Thr Leu Gln Cys Gly Ser Asp Val Gly Tyr Asp Arg Phe Val Leu 
                245                 250                 255     


Tyr Lys Glu Gly Glu Arg Asp Phe Leu Gln Arg Pro Gly Gln Gln Pro 
            260                 265                 270         


Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg 
        275                 280                 285             


Ser Tyr Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Ser 
    290                 295                 300                 


Glu Trp Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Thr Gly Gln 
305                 310                 315                 320 


Ile Tyr Asp Thr Val Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Ala 
                325                 330                 335     


Ser Gly Glu Asn Met Thr Leu Leu Cys Gln Ser Arg Gly Tyr Phe Asp 
            340                 345                 350         


Thr Phe Leu Leu Thr Lys Glu Gly Ala Ala His Pro Pro Leu Arg Leu 
        355                 360                 365             


Arg Ser Met Tyr Gly Ala His Lys Tyr Gln Ala Glu Phe Pro Met Ser 
    370                 375                 380                 


Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Arg 
385                 390                 395                 400 


Ser Ser Asn Pro His Leu Leu Ser Phe Pro Ser Glu Pro Leu Glu Leu 
                405                 410                 415     


Met Val Ser Gly His Ser Gly Gly Ser Ser Leu Pro Pro Thr Gly Pro 
            420                 425                 430         


Pro Ser Thr Pro Gly Leu Gly Arg Tyr Leu Glu Val Leu Ile Gly Val 
        435                 440                 445             


Ser Val Ala Phe Val Leu Leu Leu Phe Leu Leu Leu Phe Leu Leu Leu 
    450                 455                 460                 


Leu Arg Gln Arg His Ser Lys His Arg Thr Ser Asp Gln Arg Lys Thr 
465                 470                 475                 480 


Asp Phe Gln Arg Pro Ala Gly Ala Ala Glu Thr Glu Pro Lys Asp Arg 
                485                 490                 495     


Gly Leu Leu Arg Arg Ser Ser Pro Ala Ala Asp Val Gln Glu Glu Asn 
            500                 505                 510         


Leu Tyr Ala Ala Val Lys Asp Thr Gln Ser Glu Asp Arg Val Glu Leu 
        515                 520                 525             


Asp Ser Gln Gln Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr 
    530                 535                 540                 


Ala Pro Val Lys His Ser Ser Pro Arg Arg Glu Met Ala Ser Pro Pro 
545                 550                 555                 560 


Ser Ser Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Val Glu 
                565                 570                 575     


Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Ser Gln 
            580                 585                 590         


Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Lys Ala 
        595                 600                 605             


Thr Glu Pro Pro Pro Ser Gln Glu Gly Glu Pro Pro Ala Glu Pro Ser 
    610                 615                 620                 


Ile Tyr Ala Thr Leu Ala Ile His 
625                 630         


<210>  7874
<211>  643
<212>  PRT
<213>  Homo Sapiens

<400>  7874

Met Thr Pro Ala Leu Thr Ala Leu Leu Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr Arg Met Gln Ala Gly Pro Phe Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Ser Trp Gly Ser Pro Val Thr Ile Trp 
        35                  40                  45              


Cys Gln Gly Ser Leu Glu Ala Gln Glu Tyr Gln Leu Asp Lys Glu Gly 
    50                  55                  60                  


Ser Pro Glu Pro Trp Asp Arg Asn Asn Pro Leu Glu Pro Lys Asn Lys 
65                  70                  75                  80  


Ala Arg Phe Ser Ile Pro Ser Met Thr Gln His His Ala Gly Arg Tyr 
                85                  90                  95      


Arg Cys His Tyr Tyr Ser Ser Ala Gly Trp Ser Glu Pro Ser Asp Pro 
            100                 105                 110         


Leu Glu Leu Val Met Thr Gly Phe Tyr Asn Lys Pro Thr Leu Ser Ala 
        115                 120                 125             


Leu Pro Ser Pro Val Val Ala Ser Gly Gly Asn Met Thr Leu Arg Cys 
    130                 135                 140                 


Gly Ser Gln Lys Gly Tyr His His Phe Val Leu Met Lys Glu Gly Glu 
145                 150                 155                 160 


His Gln Leu Pro Arg Thr Leu Asp Ser Gln Gln Leu His Ser Gly Gly 
                165                 170                 175     


Phe Gln Ala Leu Phe Pro Val Gly Pro Val Thr Pro Ser His Arg Trp 
            180                 185                 190         


Arg Phe Thr Cys Tyr Tyr Tyr Tyr Thr Asn Thr Pro Trp Val Trp Ser 
        195                 200                 205             


His Pro Ser Asp Pro Leu Glu Ile Leu Pro Ser Gly Val Ser Arg Lys 
    210                 215                 220                 


Pro Ser Leu Leu Thr Leu Gln Gly Pro Val Leu Ala Pro Gly Gln Ser 
225                 230                 235                 240 


Leu Thr Leu Gln Cys Gly Ser Asp Val Gly Tyr Asp Arg Phe Val Leu 
                245                 250                 255     


Tyr Lys Glu Gly Glu Arg Asp Phe Leu Gln Arg Pro Gly Gln Gln Pro 
            260                 265                 270         


Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg 
        275                 280                 285             


Ser Tyr Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Ser 
    290                 295                 300                 


Glu Trp Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Thr Gly Gln 
305                 310                 315                 320 


Ile Tyr Asp Thr Val Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Ala 
                325                 330                 335     


Ser Gly Glu Asn Met Thr Leu Leu Cys Gln Ser Arg Gly Tyr Phe Asp 
            340                 345                 350         


Thr Phe Leu Leu Thr Lys Glu Gly Ala Ala His Pro Pro Leu Arg Leu 
        355                 360                 365             


Arg Ser Met Tyr Gly Ala His Lys Tyr Gln Ala Glu Phe Pro Met Ser 
    370                 375                 380                 


Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Arg 
385                 390                 395                 400 


Ser Ser Asn Pro His Leu Leu Ser Phe Pro Ser Glu Pro Leu Glu Leu 
                405                 410                 415     


Met Val Ser Gly Pro Glu Asp Gln Pro Leu Asn Pro Pro Gly Ser Gly 
            420                 425                 430         


Pro Gln Asn Ala Pro Gly Leu Gly Ser Gly Ala Gly Thr Arg Ala Ala 
        435                 440                 445             


Gly Leu Gly Arg Tyr Leu Glu Val Leu Ile Gly Val Ser Val Ala Phe 
    450                 455                 460                 


Val Leu Leu Leu Phe Leu Leu Leu Phe Leu Leu Leu Leu Arg Gln Arg 
465                 470                 475                 480 


His Ser Lys His Arg Thr Ser Asp Gln Arg Lys Thr Asp Phe Gln Arg 
                485                 490                 495     


Pro Ala Gly Ala Ala Glu Thr Glu Pro Lys Asp Arg Gly Leu Leu Arg 
            500                 505                 510         


Arg Ser Ser Pro Ala Ala Asp Val Gln Glu Glu Asn Leu Tyr Ala Ala 
        515                 520                 525             


Val Lys Asp Thr Gln Ser Glu Asp Arg Val Glu Leu Asp Ser Gln Ser 
    530                 535                 540                 


Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr Ala Pro Val Lys His 
545                 550                 555                 560 


Ser Ser Pro Arg Arg Glu Met Ala Ser Pro Pro Ser Ser Leu Ser Gly 
                565                 570                 575     


Glu Phe Leu Asp Thr Lys Asp Arg Gln Val Glu Glu Asp Arg Gln Met 
            580                 585                 590         


Asp Thr Glu Ala Ala Ala Ser Glu Ala Ser Gln Asp Val Thr Tyr Ala 
        595                 600                 605             


Gln Leu His Ser Leu Thr Leu Arg Arg Lys Ala Thr Glu Pro Pro Pro 
    610                 615                 620                 


Ser Gln Glu Gly Glu Pro Pro Ala Glu Pro Ser Ile Tyr Ala Thr Leu 
625                 630                 635                 640 


Ala Ile His 
            


<210>  7875
<211>  631
<212>  PRT
<213>  Homo Sapiens

<400>  7875

Met Thr Pro Ala Leu Thr Ala Leu Leu Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr Arg Met Gln Ala Gly Pro Phe Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Ser Trp Gly Ser Pro Val Thr Ile Trp 
        35                  40                  45              


Cys Gln Gly Ser Leu Glu Ala Gln Glu Tyr Gln Leu Asp Lys Glu Gly 
    50                  55                  60                  


Ser Pro Glu Pro Trp Asp Arg Asn Asn Pro Leu Glu Pro Lys Asn Lys 
65                  70                  75                  80  


Ala Arg Phe Ser Ile Pro Ser Met Thr Gln His His Ala Gly Arg Tyr 
                85                  90                  95      


Arg Cys His Tyr Tyr Ser Ser Ala Gly Trp Ser Glu Pro Ser Asp Pro 
            100                 105                 110         


Leu Glu Leu Val Met Thr Gly Phe Tyr Asn Lys Pro Thr Leu Ser Ala 
        115                 120                 125             


Leu Pro Ser Pro Val Val Ala Ser Gly Gly Asn Met Thr Leu Arg Cys 
    130                 135                 140                 


Gly Ser Gln Lys Gly Tyr His His Phe Val Leu Met Lys Glu Gly Glu 
145                 150                 155                 160 


His Gln Leu Pro Arg Thr Leu Asp Ser Gln Gln Leu His Ser Gly Gly 
                165                 170                 175     


Phe Gln Ala Leu Phe Pro Val Gly Pro Val Thr Pro Ser His Arg Trp 
            180                 185                 190         


Arg Phe Thr Cys Tyr Tyr Tyr Tyr Thr Asn Thr Pro Trp Val Trp Ser 
        195                 200                 205             


His Pro Ser Asp Pro Leu Glu Ile Leu Pro Ser Gly Val Ser Arg Lys 
    210                 215                 220                 


Pro Ser Leu Leu Thr Leu Gln Gly Pro Val Leu Ala Pro Gly Gln Ser 
225                 230                 235                 240 


Leu Thr Leu Gln Cys Gly Ser Asp Val Gly Tyr Asp Arg Phe Val Leu 
                245                 250                 255     


Tyr Lys Glu Gly Glu Arg Asp Phe Leu Gln Arg Pro Gly Gln Gln Pro 
            260                 265                 270         


Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg 
        275                 280                 285             


Ser Tyr Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Ser 
    290                 295                 300                 


Glu Trp Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Thr Gly Gln 
305                 310                 315                 320 


Ile Tyr Asp Thr Val Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Ala 
                325                 330                 335     


Ser Gly Glu Asn Met Thr Leu Leu Cys Gln Ser Arg Gly Tyr Phe Asp 
            340                 345                 350         


Thr Phe Leu Leu Thr Lys Glu Gly Ala Ala His Pro Pro Leu Arg Leu 
        355                 360                 365             


Arg Ser Met Tyr Gly Ala His Lys Tyr Gln Ala Glu Phe Pro Met Ser 
    370                 375                 380                 


Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Arg 
385                 390                 395                 400 


Ser Ser Asn Pro His Leu Leu Ser Phe Pro Ser Glu Pro Leu Glu Leu 
                405                 410                 415     


Met Val Ser Gly His Ser Gly Gly Ser Ser Leu Pro Pro Thr Gly Pro 
            420                 425                 430         


Pro Ser Thr Pro Gly Leu Gly Arg Tyr Leu Glu Val Leu Ile Gly Val 
        435                 440                 445             


Ser Val Ala Phe Val Leu Leu Leu Phe Leu Leu Leu Phe Leu Leu Leu 
    450                 455                 460                 


Leu Arg Gln Arg His Ser Lys His Arg Thr Ser Asp Gln Arg Lys Thr 
465                 470                 475                 480 


Asp Phe Gln Arg Pro Ala Gly Ala Ala Glu Thr Glu Pro Lys Asp Arg 
                485                 490                 495     


Gly Leu Leu Arg Arg Ser Ser Pro Ala Ala Asp Val Gln Glu Glu Asn 
            500                 505                 510         


Leu Tyr Ala Ala Val Lys Asp Thr Gln Ser Glu Asp Arg Val Glu Leu 
        515                 520                 525             


Asp Ser Gln Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr Ala 
    530                 535                 540                 


Pro Val Lys His Ser Ser Pro Arg Arg Glu Met Ala Ser Pro Pro Ser 
545                 550                 555                 560 


Ser Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Val Glu Glu 
                565                 570                 575     


Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Ser Gln Asp 
            580                 585                 590         


Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Lys Ala Thr 
        595                 600                 605             


Glu Pro Pro Pro Ser Gln Glu Gly Glu Pro Pro Ala Glu Pro Ser Ile 
    610                 615                 620                 


Tyr Ala Thr Leu Ala Ile His 
625                 630     


<210>  7876
<211>  191
<212>  PRT
<213>  Homo Sapiens

<400>  7876

Met Thr Pro Ala Leu Thr Ala Leu Leu Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr Arg Met Gln Ala Gly Pro Phe Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Ser Trp Gly Ser Pro Val Thr Ile Trp 
        35                  40                  45              


Cys Gln Gly Ser Leu Glu Ala Gln Glu Tyr Gln Leu Asp Lys Glu Gly 
    50                  55                  60                  


Ser Pro Glu Pro Trp Asp Arg Asn Asn Pro Leu Glu Pro Lys Asn Lys 
65                  70                  75                  80  


Ala Arg Phe Ser Ile Pro Ser Met Thr Gln His His Ala Gly Arg Tyr 
                85                  90                  95      


Arg Cys His Tyr Tyr Ser Ser Ala Gly Trp Ser Glu Pro Ser Asp Pro 
            100                 105                 110         


Leu Glu Leu Val Met Thr Gly Phe Tyr Asn Lys Pro Thr Leu Ser Ala 
        115                 120                 125             


Leu Pro Ser Pro Val Val Ala Ser Gly Gly Asn Met Thr Leu Arg Cys 
    130                 135                 140                 


Gly Ser Gln Lys Gly Tyr His His Phe Val Leu Met Lys Glu Gly Glu 
145                 150                 155                 160 


His Gln Leu Pro Arg Thr Leu Asp Ser Gln Gln Leu His Ser Gly Gly 
                165                 170                 175     


Phe Gln Ala Leu Phe Pro Val Gly Pro Val Thr Pro Ser His Ser 
            180                 185                 190     


<210>  7877
<211>  253
<212>  PRT
<213>  Homo Sapiens

<400>  7877

Met Gly Leu Pro Val Ser Trp Ala Pro Pro Ala Leu Trp Val Leu Gly 
1               5                   10                  15      


Cys Cys Ala Leu Leu Leu Ser Leu Trp Ala Leu Cys Thr Ala Cys Arg 
            20                  25                  30          


Arg Lys Arg Ala Arg Arg Gln Arg Ala Arg Leu Gln Gly Ser Ala Thr 
        35                  40                  45              


Ala Ala Glu Ala Ser Leu Leu Arg Arg Thr His Leu Cys Ser Leu Ser 
    50                  55                  60                  


Lys Ser Asp Thr Arg Leu His Glu Leu His Arg Gly Pro Arg Ser Ser 
65                  70                  75                  80  


Arg Ala Leu Arg Pro Ala Ser Met Asp Leu Leu Arg Pro His Trp Leu 
                85                  90                  95      


Glu Val Ser Arg Asp Ile Thr Gly Pro Gln Ala Ala Pro Ser Ala Phe 
            100                 105                 110         


Pro His Gln Glu Leu Pro Arg Ala Leu Pro Ala Ala Ala Ala Thr Ala 
        115                 120                 125             


Gly Cys Ala Gly Leu Glu Ala Thr Tyr Ser Asn Val Gly Leu Ala Ala 
    130                 135                 140                 


Leu Pro Gly Val Ser Leu Ala Ala Ser Pro Val Val Ala Glu Tyr Ala 
145                 150                 155                 160 


Arg Val Gln Lys Arg Lys Gly Thr His Arg Ser Pro Gln Glu Pro Gln 
                165                 170                 175     


Gln Gly Lys Thr Glu Val Thr Pro Ala Ala Gln Val Asp Val Leu Tyr 
            180                 185                 190         


Ser Arg Val Cys Lys Pro Lys Arg Arg Asp Pro Gly Pro Thr Thr Asp 
        195                 200                 205             


Pro Leu Asp Pro Lys Gly Gln Gly Ala Ile Leu Ala Leu Ala Gly Asp 
    210                 215                 220                 


Leu Ala Tyr Gln Thr Leu Pro Leu Arg Ala Leu Asp Val Asp Ser Gly 
225                 230                 235                 240 


Pro Leu Glu Asn Val Tyr Glu Ser Ile Arg Glu Leu Gly 
                245                 250             


<210>  7878
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  7878

Met Gly Leu Pro Val Ser Trp Ala Pro Pro Ala Leu Trp Val Leu Gly 
1               5                   10                  15      


Cys Cys Ala Leu Leu Leu Ser Leu Trp Ala Leu Cys Thr Ala Cys Arg 
            20                  25                  30          


Arg Pro Glu Asp Ala Val Ala Pro Arg Lys Arg Ala Arg Arg Gln Arg 
        35                  40                  45              


Ala Arg Leu Gln Gly Ser Ala Thr Ala Ala Glu Ala Gln Val Gly His 
    50                  55                  60                  


Gln Thr Ala Arg Ala Ala Pro Gly Pro Ala Gln Gln Gln Gly Pro Ala 
65                  70                  75                  80  


Ala Cys Gln His Gly Ser Pro Ala Pro Thr Leu Ala Gly Gly Val Gln 
                85                  90                  95      


Gly His His Arg Thr Ala Gly Ser Pro Leu Cys Leu Pro Thr Pro Gly 
            100                 105                 110         


Ala Ala Pro Gly Ser Ala Gly Ser Cys Ser His Arg Arg Val Arg Trp 
        115                 120                 125             


Pro Arg Gly 
    130     


<210>  7879
<211>  176
<212>  PRT
<213>  Homo Sapiens

<400>  7879

Met Gly Leu Pro Val Ser Trp Ala Pro Pro Ala Leu Trp Val Leu Gly 
1               5                   10                  15      


Cys Cys Ala Leu Leu Leu Ser Leu Trp Ala Leu Cys Thr Ala Cys Arg 
            20                  25                  30          


Arg Pro Glu Asp Ala Val Ala Pro Arg Lys Arg Ala Arg Arg Gln Arg 
        35                  40                  45              


Ala Arg Leu Gln Gly Ser Ala Thr Ala Ala Glu Ala Gln Val Gly His 
    50                  55                  60                  


Gln Thr Ala Arg Ala Ala Pro Gly Pro Ala Gln Gln Gln Gly Pro Ala 
65                  70                  75                  80  


Ala Cys Gln His Gly Ser Pro Ala Pro Thr Leu Ala Gly Gly Val Gln 
                85                  90                  95      


Gly His His Arg Thr Ala Gly Ser Pro Leu Cys Leu Pro Thr Pro Gly 
            100                 105                 110         


Ala Ala Pro Gly Ser Ala Gly Ser Cys Ser His Arg Arg Val Arg Trp 
        115                 120                 125             


Pro Arg Gly His Leu Phe Gln Arg Gly Ala Gly Gly Pro Ser Arg Gly 
    130                 135                 140                 


Gln Pro Gly Gly Gln Pro Cys Gly Gly Arg Val Cys Pro Arg Pro Glu 
145                 150                 155                 160 


Ala Gln Arg Asp Pro Ser Gln Ser Pro Arg Ala Thr Ala Gly Glu Asp 
                165                 170                 175     


<210>  7880
<211>  107
<212>  PRT
<213>  Homo Sapiens

<400>  7880

Met Gly Leu Pro Val Ser Trp Ala Pro Pro Ala Leu Trp Val Leu Gly 
1               5                   10                  15      


Cys Cys Ala Leu Leu Leu Ser Leu Trp Ala Leu Cys Thr Ala Cys Arg 
            20                  25                  30          


Arg Pro Glu Asp Ala Val Ala Pro Arg Lys Arg Ala Arg Arg Gln Arg 
        35                  40                  45              


Ala Arg Leu Gln Gly Ser Ala Thr Ala Ala Glu Ala Ser Leu Leu Arg 
    50                  55                  60                  


Arg Thr His Leu Cys Ser Leu Ser Lys Ser Asp Thr Arg Leu His Glu 
65                  70                  75                  80  


Leu His Arg Gly Pro Arg Ser Ser Arg Ala Leu Arg Pro Ala Ser Met 
                85                  90                  95      


Asp Leu Leu Arg Pro His Trp Leu Glu Val Ser 
            100                 105         


<210>  7881
<211>  295
<212>  PRT
<213>  Homo Sapiens

<400>  7881

Met Gly Leu Pro Val Ser Trp Ala Pro Pro Ala Leu Trp Val Leu Gly 
1               5                   10                  15      


Cys Cys Ala Leu Leu Leu Ser Leu Trp Ala Leu Cys Thr Ala Cys Arg 
            20                  25                  30          


Arg Pro Glu Asp Ala Val Ala Pro Arg Lys Arg Ala Arg Arg Gln Arg 
        35                  40                  45              


Ala Arg Leu Gln Gly Ser Ala Thr Ala Ala Glu Ala Ser Leu Leu Arg 
    50                  55                  60                  


Arg Thr His Leu Cys Ser Leu Ser Lys Ser Asp Thr Arg Leu His Glu 
65                  70                  75                  80  


Leu His Arg Gly Pro Arg Ser Ser Arg Ala Leu Arg Pro Ala Ser Met 
                85                  90                  95      


Asp Leu Leu Arg Pro His Trp Leu Glu Val Ser Arg Asp Ile Thr Gly 
            100                 105                 110         


Pro Gln Ala Ala Pro Ser Ala Phe Pro His Gln Glu Leu Pro Arg Ala 
        115                 120                 125             


Leu Pro Ala Ala Ala Ala Thr Ala Gly Cys Ala Gly Leu Glu Ala Thr 
    130                 135                 140                 


Tyr Ser Asn Val Gly Leu Ala Ala Leu Pro Gly Val Ser Leu Ala Ala 
145                 150                 155                 160 


Ser Pro Val Val Ala Glu Tyr Ala Arg Val Gln Lys Arg Lys Gly Thr 
                165                 170                 175     


His Arg Ser Pro Gln Glu Pro Gln Gln Gly Lys Thr Glu Val Thr Pro 
            180                 185                 190         


Ala Ala Gln Val Asp Val Leu Tyr Ser Arg Val Cys Lys Pro Lys Arg 
        195                 200                 205             


Arg Asp Pro Gly Pro Thr Thr Asp Pro Leu Asp Pro Lys Gly Gln Gly 
    210                 215                 220                 


Ala Ile Leu Ala Leu Ala Gly Asp Leu Ala Tyr Gln Thr Leu Pro Leu 
225                 230                 235                 240 


Arg Ala Leu Asp Val Asp Ser Gly Pro Leu Glu Asn Val Tyr Glu Ser 
                245                 250                 255     


Ile Arg Glu Leu Gly Asp Pro Ala Gly Arg Ser Ser Thr Cys Gly Ala 
            260                 265                 270         


Gly Thr Pro Pro Ala Ser Ser Cys Pro Ser Leu Gly Arg Gly Trp Arg 
        275                 280                 285             


Pro Leu Pro Ala Ser Leu Pro 
    290                 295 


<210>  7882
<211>  211
<212>  PRT
<213>  Homo Sapiens

<400>  7882

Met Gly Leu Pro Val Ser Trp Ala Pro Pro Ala Leu Trp Val Leu Gly 
1               5                   10                  15      


Cys Cys Ala Leu Leu Leu Ser Leu Trp Ala Leu Cys Thr Ala Cys Arg 
            20                  25                  30          


Arg Pro Glu Asp Ala Val Ala Pro Arg Lys Arg Ala Arg Arg Gln Arg 
        35                  40                  45              


Ala Arg Leu Gln Gly Ser Ala Thr Ala Ala Glu Ala Val Ser Ala Arg 
    50                  55                  60                  


Leu Ser Arg Gly Pro Gly Trp Gly Pro Gln Gly Thr Asp Gln Pro Ser 
65                  70                  75                  80  


Ser Pro Pro Val Pro Thr Glu Ala Asp Pro Pro Leu Leu Pro Gln Gln 
                85                  90                  95      


Val Gly His Gln Thr Ala Arg Ala Ala Pro Gly Pro Ala Gln Gln Gln 
            100                 105                 110         


Gly Pro Ala Ala Cys Gln His Gly Ser Pro Ala Pro Thr Leu Ala Gly 
        115                 120                 125             


Gly Val Gln Gly His His Arg Thr Ala Gly Ser Pro Leu Cys Leu Pro 
    130                 135                 140                 


Thr Pro Gly Ala Ala Pro Gly Ser Ala Gly Ser Cys Ser His Arg Arg 
145                 150                 155                 160 


Val Arg Trp Pro Arg Gly His Leu Phe Gln Arg Gly Ala Gly Gly Pro 
                165                 170                 175     


Ser Arg Gly Gln Pro Gly Gly Gln Pro Cys Gly Gly Arg Val Cys Pro 
            180                 185                 190         


Arg Pro Glu Ala Gln Arg Asp Pro Ser Gln Ser Pro Arg Ala Thr Ala 
        195                 200                 205             


Gly Glu Asp 
    210     


<210>  7883
<211>  4
<212>  PRT
<213>  Homo Sapiens

<400>  7883

Met Leu Ala Gly 
1               


<210>  7884
<211>  12
<212>  PRT
<213>  Homo Sapiens

<400>  7884

Met Leu Ala Gly Gly Val Arg Ser Met Pro Ser Pro 
1               5                   10          


<210>  7885
<211>  19
<212>  PRT
<213>  Homo Sapiens

<400>  7885

Met Leu Ala Gly Gly Val Arg Ser Met Pro Ser Pro Leu Leu Ala Cys 
1               5                   10                  15      


Trp Gln Pro 
            


<210>  7886
<211>  35
<212>  PRT
<213>  Homo Sapiens

<400>  7886

Met Leu Ala Gly Gly Val Arg Ser Met Pro Ser Pro Leu Leu Ala Cys 
1               5                   10                  15      


Trp Gln Pro Ile Leu Leu Leu Val Leu Gly Ser Val Leu Ser Gly Ser 
            20                  25                  30          


Ala Thr Gly 
        35  


<210>  7887
<211>  55
<212>  PRT
<213>  Homo Sapiens

<400>  7887

Met Leu Ala Gly Gly Val Arg Ser Met Pro Ser Pro Leu Leu Ala Cys 
1               5                   10                  15      


Trp Gln Pro Ile Leu Leu Leu Val Leu Gly Ser Val Leu Ser Gly Ser 
            20                  25                  30          


Ala Thr Gly Cys Pro Pro Arg Cys Glu Cys Ser Ala Gln Asp Arg Ala 
        35                  40                  45              


Val Leu Cys His Arg Lys Arg 
    50                  55  


<210>  7888
<211>  72
<212>  PRT
<213>  Homo Sapiens

<400>  7888

Met Leu Ala Gly Gly Val Arg Ser Met Pro Ser Pro Leu Leu Ala Cys 
1               5                   10                  15      


Trp Gln Pro Ile Leu Leu Leu Val Leu Gly Ser Val Leu Ser Gly Ser 
            20                  25                  30          


Ala Thr Gly Cys Pro Pro Arg Cys Glu Cys Ser Ala Gln Asp Arg Ala 
        35                  40                  45              


Val Leu Cys His Arg Lys Arg Phe Val Ala Val Pro Glu Gly Ile Pro 
    50                  55                  60                  


Thr Glu Thr Arg Leu Leu Asp Leu 
65                  70          


<210>  7889
<211>  125
<212>  PRT
<213>  Homo Sapiens

<400>  7889

Met Leu Ala Gly Gly Val Arg Ser Met Pro Ser Pro Leu Leu Ala Cys 
1               5                   10                  15      


Trp Gln Pro Ile Leu Leu Leu Val Leu Gly Ser Val Leu Ser Gly Ser 
            20                  25                  30          


Ala Thr Gly Cys Pro Pro Arg Cys Glu Cys Ser Ala Gln Asp Arg Ala 
        35                  40                  45              


Val Leu Cys His Arg Lys Arg Phe Val Ala Val Pro Glu Gly Ile Pro 
    50                  55                  60                  


Thr Glu Thr Arg Leu Leu Asp Leu Gly Lys Asn Arg Ile Lys Thr Leu 
65                  70                  75                  80  


Asn Gln Asp Glu Phe Ala Ser Phe Pro His Leu Glu Glu Leu Glu Leu 
                85                  90                  95      


Asn Glu Asn Ile Val Ser Ala Val Glu Pro Gly Ala Phe Asn Asn Leu 
            100                 105                 110         


Phe Asn Leu Arg Thr Leu Gly Leu Arg Ser Asn Arg Leu 
        115                 120                 125 


<210>  7890
<211>  179
<212>  PRT
<213>  Homo Sapiens

<400>  7890

Met Leu Ala Gly Gly Val Arg Ser Met Pro Ser Pro Leu Leu Ala Cys 
1               5                   10                  15      


Trp Gln Pro Ile Leu Leu Leu Val Leu Gly Ser Val Leu Ser Gly Ser 
            20                  25                  30          


Ala Thr Gly Cys Pro Pro Arg Cys Glu Cys Ser Ala Gln Asp Arg Ala 
        35                  40                  45              


Val Leu Cys His Arg Lys Arg Phe Val Ala Val Pro Glu Gly Ile Pro 
    50                  55                  60                  


Thr Glu Thr Arg Leu Leu Asp Leu Gly Lys Asn Arg Ile Lys Thr Leu 
65                  70                  75                  80  


Asn Gln Asp Glu Phe Ala Ser Phe Pro His Leu Glu Glu Leu Glu Leu 
                85                  90                  95      


Asn Glu Asn Ile Val Ser Ala Val Glu Pro Gly Ala Phe Asn Asn Leu 
            100                 105                 110         


Phe Asn Leu Arg Thr Leu Gly Leu Arg Ser Asn Arg Leu Lys Leu Ile 
        115                 120                 125             


Pro Leu Gly Val Phe Thr Gly Leu Ser Asn Leu Thr Lys Leu Asp Ile 
    130                 135                 140                 


Ser Glu Asn Lys Ile Val Ile Leu Leu Asp Tyr Met Phe Gln Asp Leu 
145                 150                 155                 160 


Tyr Asn Leu Lys Ser Leu Glu Val Gly Asp Asn Asp Leu Val Tyr Ile 
                165                 170                 175     


Ser His Arg 
            


<210>  7891
<211>  614
<212>  PRT
<213>  Homo Sapiens

<400>  7891

Met Leu Ala Gly Gly Val Arg Ser Met Pro Ser Pro Leu Leu Ala Cys 
1               5                   10                  15      


Trp Gln Pro Ile Leu Leu Leu Val Leu Gly Ser Val Leu Ser Gly Ser 
            20                  25                  30          


Ala Thr Gly Cys Pro Pro Arg Cys Glu Cys Ser Ala Gln Asp Arg Ala 
        35                  40                  45              


Val Leu Cys His Arg Lys Arg Phe Val Ala Val Pro Glu Gly Ile Pro 
    50                  55                  60                  


Thr Glu Thr Arg Leu Leu Asp Leu Gly Lys Asn Arg Ile Lys Thr Leu 
65                  70                  75                  80  


Asn Gln Asp Glu Phe Ala Ser Phe Pro His Leu Glu Glu Leu Glu Leu 
                85                  90                  95      


Asn Glu Asn Ile Val Ser Ala Val Glu Pro Gly Ala Phe Asn Asn Leu 
            100                 105                 110         


Phe Asn Leu Arg Thr Leu Gly Leu Arg Ser Asn Arg Leu Lys Leu Ile 
        115                 120                 125             


Pro Leu Gly Val Phe Thr Gly Leu Ser Asn Leu Thr Lys Leu Asp Ile 
    130                 135                 140                 


Ser Glu Asn Lys Ile Val Ile Leu Leu Asp Tyr Met Phe Gln Asp Leu 
145                 150                 155                 160 


Tyr Asn Leu Lys Ser Leu Glu Val Gly Asp Asn Asp Leu Val Tyr Ile 
                165                 170                 175     


Ser His Arg Ala Phe Ser Gly Leu Asn Ser Leu Glu Gln Leu Thr Leu 
            180                 185                 190         


Glu Lys Cys Asn Leu Thr Ser Ile Pro Thr Glu Ala Leu Ser His Leu 
        195                 200                 205             


His Gly Leu Ile Val Leu Arg Leu Arg His Leu Asn Ile Asn Ala Ile 
    210                 215                 220                 


Arg Asp Tyr Ser Phe Lys Arg Leu Tyr Arg Leu Lys Val Leu Glu Ile 
225                 230                 235                 240 


Ser His Trp Pro Tyr Leu Asp Thr Met Thr Pro Asn Cys Leu Tyr Gly 
                245                 250                 255     


Leu Asn Leu Thr Ser Leu Ser Ile Thr His Cys Asn Leu Thr Ala Val 
            260                 265                 270         


Pro Tyr Leu Ala Val Arg His Leu Val Tyr Leu Arg Phe Leu Asn Leu 
        275                 280                 285             


Ser Tyr Asn Pro Ile Ser Thr Ile Glu Gly Ser Met Leu His Glu Leu 
    290                 295                 300                 


Leu Arg Leu Gln Glu Ile Gln Leu Val Gly Gly Gln Leu Ala Val Val 
305                 310                 315                 320 


Glu Pro Tyr Ala Phe Arg Gly Leu Asn Tyr Leu Arg Val Leu Asn Val 
                325                 330                 335     


Ser Gly Asn Gln Leu Thr Thr Leu Glu Glu Ser Val Phe His Ser Val 
            340                 345                 350         


Gly Asn Leu Glu Thr Leu Ile Leu Asp Ser Asn Pro Leu Ala Cys Asp 
        355                 360                 365             


Cys Arg Leu Leu Trp Val Phe Arg Arg Arg Trp Arg Leu Asn Phe Asn 
    370                 375                 380                 


Arg Gln Gln Pro Thr Cys Ala Thr Pro Glu Phe Val Gln Gly Lys Glu 
385                 390                 395                 400 


Phe Lys Asp Phe Pro Asp Val Leu Leu Pro Asn Tyr Phe Thr Cys Arg 
                405                 410                 415     


Arg Ala Arg Ile Arg Asp Arg Lys Ala Gln Gln Val Phe Val Asp Glu 
            420                 425                 430         


Gly His Thr Val Gln Phe Val Cys Arg Ala Asp Gly Asp Pro Pro Pro 
        435                 440                 445             


Ala Ile Leu Trp Leu Ser Pro Arg Lys His Leu Val Ser Ala Lys Ser 
    450                 455                 460                 


Asn Gly Arg Leu Thr Val Phe Pro Asp Gly Thr Leu Glu Val Arg Tyr 
465                 470                 475                 480 


Ala Gln Val Gln Asp Asn Gly Thr Tyr Leu Cys Ile Ala Ala Asn Ala 
                485                 490                 495     


Gly Gly Asn Asp Ser Met Pro Ala His Leu His Val Arg Ser Tyr Ser 
            500                 505                 510         


Pro Asp Trp Pro His Gln Pro Asn Lys Thr Phe Ala Phe Ile Ser Asn 
        515                 520                 525             


Gln Pro Gly Glu Gly Glu Ala Asn Ser Thr Arg Ala Thr Val Pro Phe 
    530                 535                 540                 


Pro Phe Asp Ile Lys Thr Leu Ile Ile Ala Thr Thr Met Gly Phe Ile 
545                 550                 555                 560 


Ser Phe Leu Gly Val Val Leu Phe Cys Leu Val Leu Leu Phe Leu Trp 
                565                 570                 575     


Ser Arg Gly Lys Gly Asn Thr Lys His Asn Ile Glu Ile Glu Tyr Val 
            580                 585                 590         


Pro Arg Lys Ser Asp Ala Gly Ile Ser Ser Ala Asp Ala Pro Arg Lys 
        595                 600                 605             


Phe Asn Met Lys Met Ile 
    610                 


<210>  7892
<211>  620
<212>  PRT
<213>  Homo Sapiens

<400>  7892

Met Gln Val Ser Lys Arg Met Leu Ala Gly Gly Val Arg Ser Met Pro 
1               5                   10                  15      


Ser Pro Leu Leu Ala Cys Trp Gln Pro Ile Leu Leu Leu Val Leu Gly 
            20                  25                  30          


Ser Val Leu Ser Gly Ser Ala Thr Gly Cys Pro Pro Arg Cys Glu Cys 
        35                  40                  45              


Ser Ala Gln Asp Arg Ala Val Leu Cys His Arg Lys Arg Phe Val Ala 
    50                  55                  60                  


Val Pro Glu Gly Ile Pro Thr Glu Thr Arg Leu Leu Asp Leu Gly Lys 
65                  70                  75                  80  


Asn Arg Ile Lys Thr Leu Asn Gln Asp Glu Phe Ala Ser Phe Pro His 
                85                  90                  95      


Leu Glu Glu Leu Glu Leu Asn Glu Asn Ile Val Ser Ala Val Glu Pro 
            100                 105                 110         


Gly Ala Phe Asn Asn Leu Phe Asn Leu Arg Thr Leu Gly Leu Arg Ser 
        115                 120                 125             


Asn Arg Leu Lys Leu Ile Pro Leu Gly Val Phe Thr Gly Leu Ser Asn 
    130                 135                 140                 


Leu Thr Lys Leu Asp Ile Ser Glu Asn Lys Ile Val Ile Leu Leu Asp 
145                 150                 155                 160 


Tyr Met Phe Gln Asp Leu Tyr Asn Leu Lys Ser Leu Glu Val Gly Asp 
                165                 170                 175     


Asn Asp Leu Val Tyr Ile Ser His Arg Ala Phe Ser Gly Leu Asn Ser 
            180                 185                 190         


Leu Glu Gln Leu Thr Leu Glu Lys Cys Asn Leu Thr Ser Ile Pro Thr 
        195                 200                 205             


Glu Ala Leu Ser His Leu His Gly Leu Ile Val Leu Arg Leu Arg His 
    210                 215                 220                 


Leu Asn Ile Asn Ala Ile Arg Asp Tyr Ser Phe Lys Arg Leu Tyr Arg 
225                 230                 235                 240 


Leu Lys Val Leu Glu Ile Ser His Trp Pro Tyr Leu Asp Thr Met Thr 
                245                 250                 255     


Pro Asn Cys Leu Tyr Gly Leu Asn Leu Thr Ser Leu Ser Ile Thr His 
            260                 265                 270         


Cys Asn Leu Thr Ala Val Pro Tyr Leu Ala Val Arg His Leu Val Tyr 
        275                 280                 285             


Leu Arg Phe Leu Asn Leu Ser Tyr Asn Pro Ile Ser Thr Ile Glu Gly 
    290                 295                 300                 


Ser Met Leu His Glu Leu Leu Arg Leu Gln Glu Ile Gln Leu Val Gly 
305                 310                 315                 320 


Gly Gln Leu Ala Val Val Glu Pro Tyr Ala Phe Arg Gly Leu Asn Tyr 
                325                 330                 335     


Leu Arg Val Leu Asn Val Ser Gly Asn Gln Leu Thr Thr Leu Glu Glu 
            340                 345                 350         


Ser Val Phe His Ser Val Gly Asn Leu Glu Thr Leu Ile Leu Asp Ser 
        355                 360                 365             


Asn Pro Leu Ala Cys Asp Cys Arg Leu Leu Trp Val Phe Arg Arg Arg 
    370                 375                 380                 


Trp Arg Leu Asn Phe Asn Arg Gln Gln Pro Thr Cys Ala Thr Pro Glu 
385                 390                 395                 400 


Phe Val Gln Gly Lys Glu Phe Lys Asp Phe Pro Asp Val Leu Leu Pro 
                405                 410                 415     


Asn Tyr Phe Thr Cys Arg Arg Ala Arg Ile Arg Asp Arg Lys Ala Gln 
            420                 425                 430         


Gln Val Phe Val Asp Glu Gly His Thr Val Gln Phe Val Cys Arg Ala 
        435                 440                 445             


Asp Gly Asp Pro Pro Pro Ala Ile Leu Trp Leu Ser Pro Arg Lys His 
    450                 455                 460                 


Leu Val Ser Ala Lys Ser Asn Gly Arg Leu Thr Val Phe Pro Asp Gly 
465                 470                 475                 480 


Thr Leu Glu Val Arg Tyr Ala Gln Val Gln Asp Asn Gly Thr Tyr Leu 
                485                 490                 495     


Cys Ile Ala Ala Asn Ala Gly Gly Asn Asp Ser Met Pro Ala His Leu 
            500                 505                 510         


His Val Arg Ser Tyr Ser Pro Asp Trp Pro His Gln Pro Asn Lys Thr 
        515                 520                 525             


Phe Ala Phe Ile Ser Asn Gln Pro Gly Glu Gly Glu Ala Asn Ser Thr 
    530                 535                 540                 


Arg Ala Thr Val Pro Phe Pro Phe Asp Ile Lys Thr Leu Ile Ile Ala 
545                 550                 555                 560 


Thr Thr Met Gly Phe Ile Ser Phe Leu Gly Val Val Leu Phe Cys Leu 
                565                 570                 575     


Val Leu Leu Phe Leu Trp Ser Arg Gly Lys Gly Asn Thr Lys His Asn 
            580                 585                 590         


Ile Glu Ile Glu Tyr Val Pro Arg Lys Ser Asp Ala Gly Ile Ser Ser 
        595                 600                 605             


Ala Asp Ala Pro Arg Lys Phe Asn Met Lys Met Ile 
    610                 615                 620 


<210>  7893
<211>  326
<212>  PRT
<213>  Homo Sapiens

<400>  7893

Met Val Gln Leu Glu Gln Lys Val Ser Lys Arg Met Leu Ala Gly Gly 
1               5                   10                  15      


Val Arg Ser Met Pro Ser Pro Leu Leu Ala Cys Trp Gln Pro Ile Leu 
            20                  25                  30          


Leu Leu Val Leu Gly Ser Val Leu Ser Gly Ser Ala Thr Gly Cys Pro 
        35                  40                  45              


Pro Arg Cys Glu Cys Ser Ala Gln Asp Arg Ala Val Leu Cys His Arg 
    50                  55                  60                  


Lys Arg Phe Val Ala Val Pro Glu Gly Ile Pro Thr Glu Thr Arg Leu 
65                  70                  75                  80  


Leu Asp Leu Gly Lys Asn Arg Ile Lys Thr Leu Asn Gln Asp Glu Phe 
                85                  90                  95      


Ala Ser Phe Pro His Leu Glu Glu Leu Glu Leu Asn Glu Asn Ile Val 
            100                 105                 110         


Ser Ala Val Glu Pro Gly Ala Phe Asn Asn Leu Phe Asn Leu Arg Thr 
        115                 120                 125             


Leu Gly Leu Arg Ser Asn Arg Leu Lys Leu Ile Pro Leu Gly Val Phe 
    130                 135                 140                 


Thr Gly Leu Ser Asn Leu Thr Lys Leu Asp Ile Ser Glu Asn Lys Ile 
145                 150                 155                 160 


Val Ile Leu Leu Asp Tyr Met Phe Gln Asp Leu Tyr Asn Leu Lys Ser 
                165                 170                 175     


Leu Glu Val Gly Asp Asn Asp Leu Val Tyr Ile Ser His Arg Ala Phe 
            180                 185                 190         


Ser Gly Leu Asn Ser Leu Glu Gln Leu Thr Leu Glu Lys Cys Asn Leu 
        195                 200                 205             


Thr Ser Ile Pro Thr Glu Ala Leu Ser His Leu His Gly Leu Ile Val 
    210                 215                 220                 


Leu Arg Leu Arg His Leu Asn Ile Asn Ala Ile Arg Asp Tyr Ser Phe 
225                 230                 235                 240 


Lys Arg Leu Tyr Arg Leu Lys Val Leu Glu Ile Ser His Trp Pro Tyr 
                245                 250                 255     


Leu Asp Thr Met Thr Pro Asn Cys Leu Tyr Gly Leu Asn Leu Thr Ser 
            260                 265                 270         


Leu Ser Ile Thr His Cys Asn Leu Thr Ala Val Pro Tyr Leu Ala Val 
        275                 280                 285             


Arg His Leu Val Tyr Leu Arg Phe Leu Asn Leu Ser Tyr Asn Pro Ile 
    290                 295                 300                 


Ser Thr Ile Glu Gly Ser Met Leu His Glu Leu Leu Arg Leu Gln Glu 
305                 310                 315                 320 


Ile Gln Leu Val Gly Gly 
                325     


<210>  7894
<211>  343
<212>  PRT
<213>  Homo Sapiens

<400>  7894

Met Ala Cys Leu Glu Phe Val Pro Phe Asp Val Gln Met Cys Leu Glu 
1               5                   10                  15      


Phe Leu Pro Ser Gly Pro Lys Pro Val Val Phe Leu Gln His Gly Leu 
            20                  25                  30          


Leu Ala Asp Ser Ser Asn Trp Val Thr Asn Leu Ala Asn Ser Ser Leu 
        35                  40                  45              


Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp Val Trp Met Gly Asn Ser 
    50                  55                  60                  


Arg Gly Asn Thr Trp Ser Arg Lys His Lys Thr Leu Ser Val Ser Gln 
65                  70                  75                  80  


Asp Glu Phe Trp Ala Phe Ser Tyr Asp Glu Met Ala Lys Tyr Asp Leu 
                85                  90                  95      


Pro Ala Ser Ile Asn Phe Ile Leu Asn Lys Thr Gly Gln Glu Gln Val 
            100                 105                 110         


Tyr Tyr Val Gly His Ser Gln Gly Thr Thr Ile Gly Phe Ile Ala Phe 
        115                 120                 125             


Ser Gln Ile Pro Glu Leu Ala Lys Arg Ile Lys Met Phe Phe Ala Leu 
    130                 135                 140                 


Gly Pro Val Ala Ser Val Ala Phe Cys Thr Ser Pro Met Ala Lys Leu 
145                 150                 155                 160 


Gly Arg Leu Pro Asp His Leu Ile Lys Asp Leu Phe Gly Asp Lys Glu 
                165                 170                 175     


Phe Leu Pro Gln Ser Ala Phe Leu Lys Trp Leu Gly Thr His Val Cys 
            180                 185                 190         


Thr His Val Ile Leu Lys Glu Leu Cys Gly Asn Leu Cys Phe Leu Leu 
        195                 200                 205             


Cys Gly Phe Asn Glu Arg Asn Leu Asn Met Ser Arg Val Asp Val Tyr 
    210                 215                 220                 


Thr Thr His Ser Pro Ala Gly Thr Ser Val Gln Asn Met Leu His Trp 
225                 230                 235                 240 


Ser Gln Ala Val Lys Phe Gln Lys Phe Gln Ala Phe Asp Trp Gly Ser 
                245                 250                 255     


Ser Ala Lys Asn Tyr Phe His Tyr Asn Gln Ser Tyr Pro Pro Thr Tyr 
            260                 265                 270         


Asn Val Lys Asp Met Leu Val Pro Thr Ala Val Trp Ser Gly Gly His 
        275                 280                 285             


Asp Trp Leu Ala Asp Val Tyr Asp Val Asn Ile Leu Leu Thr Gln Ile 
    290                 295                 300                 


Thr Asn Leu Val Phe His Glu Ser Ile Pro Glu Trp Glu His Leu Asp 
305                 310                 315                 320 


Phe Ile Trp Gly Leu Asp Ala Pro Trp Arg Leu Tyr Asn Lys Ile Ile 
                325                 330                 335     


Asn Leu Met Arg Lys Tyr Gln 
            340             


<210>  7895
<211>  283
<212>  PRT
<213>  Homo Sapiens

<400>  7895

Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys His Lys Thr Leu 
1               5                   10                  15      


Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr Asp Glu Met Ala 
            20                  25                  30          


Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu Asn Lys Thr Gly 
        35                  40                  45              


Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly Thr Thr Ile Gly 
    50                  55                  60                  


Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys Arg Ile Lys Met 
65                  70                  75                  80  


Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe Cys Thr Ser Pro 
                85                  90                  95      


Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile Lys Asp Leu Phe 
            100                 105                 110         


Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu Lys Trp Leu Gly 
        115                 120                 125             


Thr His Val Cys Thr His Val Ile Leu Lys Glu Leu Cys Gly Asn Leu 
    130                 135                 140                 


Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu Asn Met Ser Arg 
145                 150                 155                 160 


Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr Ser Val Gln Asn 
                165                 170                 175     


Met Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys Phe Gln Ala Phe 
            180                 185                 190         


Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr Asn Gln Ser Tyr 
        195                 200                 205             


Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro Thr Ala Val Trp 
    210                 215                 220                 


Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp Val Asn Ile Leu 
225                 230                 235                 240 


Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser Ile Pro Glu Trp 
                245                 250                 255     


Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro Trp Arg Leu Tyr 
            260                 265                 270         


Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
        275                 280             


<210>  7896
<211>  219
<212>  PRT
<213>  Homo Sapiens

<400>  7896

Met Lys Met Arg Phe Leu Gly Leu Val Val Cys Leu Val Leu Trp Thr 
1               5                   10                  15      


Leu His Ser Glu Gly Ser Gly Gly Lys Leu Thr Ala Val Asp Pro Glu 
            20                  25                  30          


Thr Asn Met Asn Val Ser Glu Ile Ile Ser Tyr Trp Gly Phe Pro Ser 
        35                  40                  45              


Glu Glu Tyr Leu Val Glu Thr Glu Asp Gly Tyr Ile Leu Cys Leu Asn 
    50                  55                  60                  


Arg Ile Pro His Gly Arg Lys Asn His Ser Asp Lys Gly Pro Lys Pro 
65                  70                  75                  80  


Val Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val 
                85                  90                  95      


Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly 
            100                 105                 110         


Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys 
        115                 120                 125             


His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr 
    130                 135                 140                 


Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu 
145                 150                 155                 160 


Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly 
                165                 170                 175     


Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys 
            180                 185                 190         


Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe 
        195                 200                 205             


Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu 
    210                 215                 


<210>  7897
<211>  399
<212>  PRT
<213>  Homo Sapiens

<400>  7897

Met Lys Met Arg Phe Leu Gly Leu Val Val Cys Leu Val Leu Trp Thr 
1               5                   10                  15      


Leu His Ser Glu Gly Ser Gly Gly Lys Leu Thr Ala Val Asp Pro Glu 
            20                  25                  30          


Thr Asn Met Asn Val Ser Glu Ile Ile Ser Tyr Trp Gly Phe Pro Ser 
        35                  40                  45              


Glu Glu Tyr Leu Val Glu Thr Glu Asp Gly Tyr Ile Leu Cys Leu Asn 
    50                  55                  60                  


Arg Ile Pro His Gly Arg Lys Asn His Ser Asp Lys Gly Pro Lys Pro 
65                  70                  75                  80  


Val Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val 
                85                  90                  95      


Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly 
            100                 105                 110         


Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys 
        115                 120                 125             


His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr 
    130                 135                 140                 


Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu 
145                 150                 155                 160 


Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly 
                165                 170                 175     


Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys 
            180                 185                 190         


Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe 
        195                 200                 205             


Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile 
    210                 215                 220                 


Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu 
225                 230                 235                 240 


Lys Trp Leu Gly Thr His Val Cys Thr His Val Ile Leu Lys Glu Leu 
                245                 250                 255     


Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu 
            260                 265                 270         


Asn Met Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr 
        275                 280                 285             


Ser Val Gln Asn Met Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys 
    290                 295                 300                 


Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr 
305                 310                 315                 320 


Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro 
                325                 330                 335     


Thr Ala Val Trp Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp 
            340                 345                 350         


Val Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser 
        355                 360                 365             


Ile Pro Glu Trp Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro 
    370                 375                 380                 


Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
385                 390                 395                 


<210>  7898
<211>  290
<212>  PRT
<213>  Homo Sapiens

<400>  7898

Met Lys Met Arg Phe Leu Gly Leu Val Val Cys Leu Val Leu Trp Thr 
1               5                   10                  15      


Leu His Ser Glu Gly Ser Gly Gly Lys Leu Thr Ala Val Asp Pro Glu 
            20                  25                  30          


Thr Asn Met Asn Val Ser Glu Ile Ile Ser Tyr Trp Gly Phe Pro Ser 
        35                  40                  45              


Glu Glu Tyr Leu Val Glu Thr Glu Asp Gly Tyr Ile Leu Cys Leu Asn 
    50                  55                  60                  


Arg Ile Pro His Gly Arg Lys Asn His Ser Asp Lys Gly Pro Lys Pro 
65                  70                  75                  80  


Val Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val 
                85                  90                  95      


Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly 
            100                 105                 110         


Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys 
        115                 120                 125             


His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr 
    130                 135                 140                 


Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu 
145                 150                 155                 160 


Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly 
                165                 170                 175     


Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys 
            180                 185                 190         


Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe 
        195                 200                 205             


Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile 
    210                 215                 220                 


Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu 
225                 230                 235                 240 


Lys Trp Leu Gly Thr His Val Cys Thr His Val Ile Leu Lys Glu Leu 
                245                 250                 255     


Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu 
            260                 265                 270         


Asn Met Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr 
        275                 280                 285             


Ser Val 
    290 


<210>  7899
<211>  438
<212>  PRT
<213>  Homo Sapiens

<400>  7899

Met Asp Thr Ser Pro Leu Cys Phe Ser Ile Leu Leu Val Leu Cys Ile 
1               5                   10                  15      


Phe Ile Gln Ser Ser Ala Leu Gly Gln Ser Leu Lys Pro Glu Pro Phe 
            20                  25                  30          


Gly Arg Arg Ala Gln Ala Val Glu Thr Asn Lys Thr Leu His Glu Met 
        35                  40                  45              


Lys Thr Arg Phe Leu Leu Phe Gly Glu Thr Asn Gln Gly Cys Gln Ile 
    50                  55                  60                  


Arg Ile Asn His Pro Asp Thr Leu Gln Glu Cys Gly Phe Asn Ser Ser 
65                  70                  75                  80  


Leu Pro Leu Val Met Ile Ile His Gly Trp Ser Glu Ser Val Gln Leu 
                85                  90                  95      


Ser Arg Ser His Val His Leu Ile Gly Tyr Ser Leu Gly Ala His Val 
            100                 105                 110         


Ser Gly Phe Ala Gly Ser Ser Ile Gly Gly Thr His Lys Ile Gly Arg 
        115                 120                 125             


Ile Thr Gly Leu Asp Ala Ala Gly Pro Leu Phe Glu Gly Ser Ala Pro 
    130                 135                 140                 


Ser Asn Arg Leu Ser Pro Asp Asp Ala Asn Phe Val Asp Ala Ile His 
145                 150                 155                 160 


Thr Phe Thr Arg Glu His Met Gly Leu Ser Val Gly Ile Lys Gln Pro 
                165                 170                 175     


Ile Gly His Tyr Asp Phe Tyr Pro Asn Gly Gly Ser Phe Gln Pro Gly 
            180                 185                 190         


Cys His Phe Leu Glu Leu Tyr Arg His Ile Ala Gln His Gly Phe Asn 
        195                 200                 205             


Ala Ile Thr Gln Thr Ile Lys Cys Ser His Glu Arg Ser Val His Leu 
    210                 215                 220                 


Phe Ile Asp Ser Leu Leu His Ala Gly Thr Gln Ser Met Ala Tyr Pro 
225                 230                 235                 240 


Cys Gly Asp Met Asn Ser Phe Ser Gln Gly Leu Cys Leu Ser Cys Lys 
                245                 250                 255     


Lys Gly Arg Cys Asn Thr Leu Gly Tyr His Val Arg Gln Glu Pro Arg 
            260                 265                 270         


Ser Lys Ser Lys Arg Leu Phe Leu Val Thr Arg Ala Gln Ser Pro Phe 
        275                 280                 285             


Lys Val Tyr His Tyr Gln Phe Lys Ile Gln Phe Ile Asn Gln Thr Glu 
    290                 295                 300                 


Thr Pro Ile Gln Thr Thr Phe Thr Met Ser Leu Leu Gly Thr Lys Glu 
305                 310                 315                 320 


Lys Met Gln Lys Ile Pro Ile Thr Leu Gly Lys Gly Ile Ala Ser Asn 
                325                 330                 335     


Lys Thr Tyr Ser Phe Leu Ile Thr Leu Asp Val Asp Ile Gly Glu Leu 
            340                 345                 350         


Ile Met Ile Lys Phe Lys Trp Glu Asn Ser Ala Val Trp Ala Asn Val 
        355                 360                 365             


Trp Asp Thr Val Gln Thr Ile Ile Pro Trp Ser Thr Gly Pro Arg His 
    370                 375                 380                 


Ser Gly Leu Val Leu Lys Thr Ile Arg Val Lys Ala Gly Glu Thr Gln 
385                 390                 395                 400 


Gln Arg Met Thr Phe Cys Ser Glu Asn Thr Asp Asp Leu Leu Leu Arg 
                405                 410                 415     


Pro Thr Gln Glu Lys Ile Phe Val Lys Cys Glu Ile Lys Ser Lys Thr 
            420                 425                 430         


Ser Lys Arg Lys Ile Arg 
        435             


<210>  7900
<211>  499
<212>  PRT
<213>  Homo Sapiens

<400>  7900

Met Asp Thr Ser Pro Leu Cys Phe Ser Ile Leu Leu Val Leu Cys Ile 
1               5                   10                  15      


Phe Ile Gln Ser Ser Ala Leu Gly Gln Ser Leu Lys Pro Glu Pro Phe 
            20                  25                  30          


Gly Arg Arg Ala Gln Ala Val Glu Thr Asn Lys Thr Leu His Glu Met 
        35                  40                  45              


Lys Thr Arg Phe Leu Leu Phe Gly Glu Thr Asn Gln Gly Cys Gln Ile 
    50                  55                  60                  


Arg Ile Asn His Pro Asp Thr Leu Gln Glu Cys Gly Phe Asn Ser Ser 
65                  70                  75                  80  


Leu Pro Leu Val Met Ile Ile His Gly Trp Ser Val Asp Gly Val Leu 
                85                  90                  95      


Glu Asn Trp Ile Trp Gln Met Val Ala Ala Leu Lys Ser Gln Pro Ala 
            100                 105                 110         


Gln Pro Val Asn Val Gly Leu Val Asp Trp Ile Thr Leu Ala His Asp 
        115                 120                 125             


His Tyr Thr Ile Ala Val Arg Asn Thr Arg Leu Val Gly Lys Glu Val 
    130                 135                 140                 


Ala Ala Leu Leu Arg Trp Leu Glu Glu Ser Val Gln Leu Ser Arg Ser 
145                 150                 155                 160 


His Val His Leu Ile Gly Tyr Ser Leu Gly Ala His Val Ser Gly Phe 
                165                 170                 175     


Ala Gly Ser Ser Ile Gly Gly Thr His Lys Ile Gly Arg Ile Thr Gly 
            180                 185                 190         


Leu Asp Ala Ala Gly Pro Leu Phe Glu Gly Ser Ala Pro Ser Asn Arg 
        195                 200                 205             


Leu Ser Pro Asp Asp Ala Asn Phe Val Asp Ala Ile His Thr Phe Thr 
    210                 215                 220                 


Arg Glu His Met Gly Leu Ser Val Gly Ile Lys Gln Pro Ile Gly His 
225                 230                 235                 240 


Tyr Asp Phe Tyr Pro Asn Gly Gly Ser Phe Gln Pro Gly Cys His Phe 
                245                 250                 255     


Leu Glu Leu Tyr Arg His Ile Ala Gln His Gly Phe Asn Ala Ile Thr 
            260                 265                 270         


Gln Thr Ile Lys Cys Ser His Glu Arg Ser Val His Leu Phe Ile Asp 
        275                 280                 285             


Ser Leu Leu His Ala Gly Thr Gln Ser Met Ala Tyr Pro Cys Gly Asp 
    290                 295                 300                 


Met Asn Ser Phe Ser Gln Gly Leu Cys Leu Ser Cys Lys Lys Gly Arg 
305                 310                 315                 320 


Cys Asn Thr Leu Gly Tyr His Val Arg Gln Glu Pro Arg Ser Lys Ser 
                325                 330                 335     


Lys Arg Leu Phe Leu Val Thr Arg Ala Gln Ser Pro Phe Lys Val Tyr 
            340                 345                 350         


His Tyr Gln Phe Lys Ile Gln Phe Ile Asn Gln Thr Glu Thr Pro Ile 
        355                 360                 365             


Gln Thr Thr Phe Thr Met Ser Leu Leu Gly Thr Lys Glu Lys Met Gln 
    370                 375                 380                 


Lys Ile Pro Ile Thr Leu Gly Lys Gly Ile Ala Ser Asn Lys Thr Tyr 
385                 390                 395                 400 


Ser Phe Leu Ile Thr Leu Asp Val Asp Ile Gly Glu Leu Ile Met Ile 
                405                 410                 415     


Lys Phe Lys Trp Glu Asn Ser Ala Val Trp Ala Asn Val Trp Asp Thr 
            420                 425                 430         


Val Gln Thr Ile Ile Pro Trp Ser Thr Gly Pro Arg His Ser Gly Leu 
        435                 440                 445             


Val Leu Lys Thr Ile Arg Val Lys Ala Gly Glu Thr Gln Gln Arg Met 
    450                 455                 460                 


Thr Phe Cys Ser Glu Asn Thr Asp Asp Leu Leu Leu Arg Pro Thr Gln 
465                 470                 475                 480 


Glu Lys Ile Phe Val Lys Cys Glu Ile Lys Ser Lys Thr Ser Lys Arg 
                485                 490                 495     


Lys Ile Arg 
            


<210>  7901
<211>  499
<212>  PRT
<213>  Homo Sapiens

<400>  7901

Met Asp Thr Ser Pro Leu Cys Phe Ser Ile Leu Leu Val Leu Cys Ile 
1               5                   10                  15      


Phe Ile Gln Ser Ser Ala Leu Gly Gln Ser Leu Lys Pro Glu Pro Phe 
            20                  25                  30          


Gly Arg Arg Ala Gln Ala Val Glu Thr Asn Lys Thr Leu His Glu Met 
        35                  40                  45              


Lys Thr Arg Phe Leu Leu Phe Gly Glu Thr Asn Gln Gly Cys Gln Ile 
    50                  55                  60                  


Arg Ile Asn His Pro Asp Thr Leu Gln Glu Cys Gly Phe Asn Ser Ser 
65                  70                  75                  80  


Leu Pro Leu Val Met Ile Ile His Gly Trp Ser Val Asp Gly Val Leu 
                85                  90                  95      


Glu Asn Trp Ile Trp Gln Met Val Ala Ala Leu Lys Ser Gln Pro Ala 
            100                 105                 110         


Gln Pro Val Asn Val Gly Leu Val Asp Trp Ile Thr Leu Ala His Asp 
        115                 120                 125             


His Tyr Thr Ile Ala Val Arg Asn Thr Arg Leu Val Gly Lys Glu Val 
    130                 135                 140                 


Ala Ala Leu Leu Arg Trp Leu Glu Glu Ser Val Gln Leu Ser Arg Ser 
145                 150                 155                 160 


His Val His Leu Ile Gly Tyr Ser Leu Gly Ala His Val Ser Gly Phe 
                165                 170                 175     


Ala Gly Ser Ser Ile Gly Gly Thr His Lys Ile Gly Arg Ile Thr Gly 
            180                 185                 190         


Leu Asp Ala Ala Gly Pro Leu Phe Glu Gly Ser Ala Pro Ser Asn Arg 
        195                 200                 205             


Leu Ser Pro Asp Asp Ala Asn Phe Val Asp Ala Ile His Thr Phe Thr 
    210                 215                 220                 


Arg Glu His Met Gly Leu Ser Val Gly Ile Lys Gln Pro Ile Gly His 
225                 230                 235                 240 


Tyr Asp Phe Tyr Pro Asn Gly Gly Ser Phe Gln Pro Gly Cys His Phe 
                245                 250                 255     


Leu Glu Leu Tyr Arg His Ile Ala Gln His Gly Phe Asn Ala Ile Thr 
            260                 265                 270         


Gln Thr Ile Lys Cys Ser His Glu Arg Ser Val His Leu Phe Ile Asp 
        275                 280                 285             


Ser Leu Leu His Ala Gly Thr Gln Ser Met Ala Tyr Pro Cys Gly Asp 
    290                 295                 300                 


Met Asn Ser Phe Ser Gln Gly Leu Cys Leu Ser Cys Lys Lys Gly Arg 
305                 310                 315                 320 


Cys Asn Thr Leu Gly Tyr His Val Arg Gln Glu Pro Arg Ser Lys Ser 
                325                 330                 335     


Lys Arg Leu Phe Leu Val Thr Arg Ala Gln Ser Pro Phe Lys Val Tyr 
            340                 345                 350         


His Tyr Gln Phe Lys Ile Gln Phe Ile Asn Gln Thr Glu Thr Pro Ile 
        355                 360                 365             


Gln Thr Thr Phe Thr Met Ser Leu Leu Gly Thr Lys Glu Lys Met Gln 
    370                 375                 380                 


Lys Ile Pro Ile Thr Leu Gly Lys Gly Ile Ala Ser Asn Lys Thr Tyr 
385                 390                 395                 400 


Ser Phe Leu Ile Thr Leu Asp Val Asp Ile Gly Glu Leu Ile Met Ile 
                405                 410                 415     


Lys Phe Lys Trp Glu Asn Ser Ala Val Trp Ala Asn Val Trp Asp Thr 
            420                 425                 430         


Val Gln Thr Ile Ile Pro Trp Ser Thr Gly Pro Arg His Ser Gly Leu 
        435                 440                 445             


Val Leu Lys Thr Ile Arg Val Lys Ala Gly Glu Thr Gln Gln Arg Met 
    450                 455                 460                 


Thr Phe Cys Ser Glu Asn Thr Asp Asp Leu Leu Leu Arg Pro Thr Gln 
465                 470                 475                 480 


Glu Lys Ile Phe Val Lys Cys Glu Ile Lys Ser Lys Thr Ser Lys Arg 
                485                 490                 495     


Lys Ile Arg 
            


<210>  7902
<211>  499
<212>  PRT
<213>  Homo Sapiens

<400>  7902

Met Asp Thr Ser Pro Leu Cys Phe Ser Ile Leu Leu Val Leu Cys Ile 
1               5                   10                  15      


Phe Ile Gln Ser Ser Ala Leu Gly Gln Ser Leu Lys Pro Glu Pro Phe 
            20                  25                  30          


Gly Arg Arg Ala Gln Ala Val Glu Thr Asn Lys Thr Leu His Glu Met 
        35                  40                  45              


Lys Thr Arg Phe Leu Leu Phe Gly Glu Thr Asn Gln Gly Cys Gln Ile 
    50                  55                  60                  


Arg Ile Asn His Pro Asp Thr Leu Gln Glu Cys Gly Phe Asn Ser Ser 
65                  70                  75                  80  


Leu Pro Leu Val Met Ile Ile His Gly Trp Ser Val Asp Gly Val Leu 
                85                  90                  95      


Glu Asn Trp Ile Trp Gln Met Val Ala Ala Leu Lys Ser Gln Pro Ala 
            100                 105                 110         


Gln Pro Val Asn Val Gly Leu Val Asp Trp Ile Thr Leu Ala His Asp 
        115                 120                 125             


His Tyr Thr Ile Ala Val Arg Asn Thr Arg Leu Val Gly Lys Glu Val 
    130                 135                 140                 


Ala Ala Leu Leu Arg Trp Leu Glu Glu Ser Val Gln Leu Ser Arg Ser 
145                 150                 155                 160 


His Val His Leu Ile Gly Tyr Ser Leu Gly Ala His Val Ser Gly Phe 
                165                 170                 175     


Ala Gly Ser Ser Ile Gly Gly Thr His Lys Ile Gly Arg Ile Thr Gly 
            180                 185                 190         


Leu Asp Ala Ala Gly Pro Leu Phe Glu Gly Ser Ala Pro Ser Asn Arg 
        195                 200                 205             


Leu Ser Pro Asp Asp Ala Asn Phe Val Asp Ala Ile His Thr Phe Thr 
    210                 215                 220                 


Arg Glu His Met Gly Leu Ser Val Gly Ile Lys Gln Pro Ile Gly His 
225                 230                 235                 240 


Tyr Asp Phe Tyr Pro Asn Gly Gly Ser Phe Gln Pro Gly Cys His Phe 
                245                 250                 255     


Leu Glu Leu Tyr Arg His Ile Ala Gln His Gly Phe Asn Ala Ile Thr 
            260                 265                 270         


Gln Thr Ile Lys Cys Ser His Glu Arg Ser Val His Leu Phe Ile Asp 
        275                 280                 285             


Ser Leu Leu His Ala Gly Thr Gln Ser Met Ala Tyr Pro Cys Gly Asp 
    290                 295                 300                 


Met Asn Ser Phe Ser Gln Gly Leu Cys Leu Ser Cys Lys Lys Gly Arg 
305                 310                 315                 320 


Cys Asn Thr Leu Gly Tyr His Val Arg Gln Glu Pro Arg Ser Lys Ser 
                325                 330                 335     


Lys Arg Leu Phe Leu Val Thr Arg Ala Gln Ser Pro Phe Lys Val Tyr 
            340                 345                 350         


His Tyr Gln Phe Lys Ile Gln Phe Ile Asn Gln Thr Glu Thr Pro Ile 
        355                 360                 365             


Gln Thr Thr Phe Thr Met Ser Leu Leu Gly Thr Lys Glu Lys Met Gln 
    370                 375                 380                 


Lys Ile Pro Ile Thr Leu Gly Lys Gly Ile Ala Ser Asn Lys Thr Tyr 
385                 390                 395                 400 


Ser Phe Leu Ile Thr Leu Asp Val Asp Ile Gly Glu Leu Ile Met Ile 
                405                 410                 415     


Lys Phe Lys Trp Glu Asn Ser Ala Val Trp Ala Asn Val Trp Asp Thr 
            420                 425                 430         


Val Gln Thr Ile Ile Pro Trp Ser Thr Gly Pro Arg His Ser Gly Leu 
        435                 440                 445             


Val Leu Lys Thr Ile Arg Val Lys Ala Gly Glu Thr Gln Gln Arg Ser 
    450                 455                 460                 


Pro Asn Arg Ile Asn Leu Gly Arg Leu Asn Cys Ser Leu Leu Phe Cys 
465                 470                 475                 480 


Thr Glu Leu Phe Ser His Asp Ser Leu Ala His Trp Ser Ser Ala Ala 
                485                 490                 495     


Ser Glu Leu 
            


<210>  7903
<211>  375
<212>  PRT
<213>  Homo Sapiens

<400>  7903

Met Phe Ser Asn Ala Asn Ser Arg Ser Lys Met Trp Leu Leu Leu Thr 
1               5                   10                  15      


Met Ala Ser Leu Ile Ser Val Leu Gly Thr Thr His Gly Leu Phe Gly 
            20                  25                  30          


Lys Leu His Pro Gly Ser Pro Glu Val Thr Met Asn Ile Ser Gln Met 
        35                  40                  45              


Ile Thr Tyr Trp Gly Tyr Pro Asn Glu Glu Tyr Glu Val Val Thr Glu 
    50                  55                  60                  


Asp Gly Tyr Ile Leu Glu Val Asn Arg Ile Pro Tyr Gly Lys Lys Asn 
65                  70                  75                  80  


Ser Gly Asn Thr Asp Ala Gly Tyr Asp Val Trp Leu Gly Asn Ser Arg 
                85                  90                  95      


Gly Asn Thr Trp Ala Arg Arg Asn Leu Tyr Tyr Ser Pro Asp Ser Val 
            100                 105                 110         


Glu Phe Trp Ala Phe Ser Phe Asp Glu Met Ala Lys Tyr Asp Leu Pro 
        115                 120                 125             


Ala Thr Ile Asp Phe Ile Val Lys Lys Thr Gly Gln Lys Gln Leu His 
    130                 135                 140                 


Tyr Val Gly His Ser Gln Gly Thr Thr Ile Gly Phe Ile Ala Phe Ser 
145                 150                 155                 160 


Thr Asn Pro Ser Leu Ala Lys Arg Ile Lys Thr Phe Tyr Ala Leu Ala 
                165                 170                 175     


Pro Val Ala Thr Val Lys Tyr Thr Lys Ser Leu Ile Asn Lys Leu Arg 
            180                 185                 190         


Phe Val Pro Gln Ser Leu Phe Lys Phe Ile Phe Gly Asp Lys Ile Phe 
        195                 200                 205             


Tyr Pro His Asn Phe Phe Asp Gln Phe Leu Ala Thr Glu Val Cys Ser 
    210                 215                 220                 


Arg Glu Met Leu Asn Leu Leu Cys Ser Asn Ala Leu Phe Ile Ile Cys 
225                 230                 235                 240 


Gly Phe Asp Ser Lys Asn Phe Asn Thr Ser Arg Leu Asp Val Tyr Leu 
                245                 250                 255     


Ser His Asn Pro Ala Gly Thr Ser Val Gln Asn Met Phe His Trp Thr 
            260                 265                 270         


Gln Ala Val Lys Ser Gly Lys Phe Gln Ala Tyr Asp Trp Gly Ser Pro 
        275                 280                 285             


Val Gln Asn Arg Met His Tyr Asp Gln Ser Gln Pro Pro Tyr Tyr Asn 
    290                 295                 300                 


Val Thr Ala Met Asn Val Pro Ile Ala Val Trp Asn Gly Gly Lys Asp 
305                 310                 315                 320 


Leu Leu Ala Asp Pro Gln Asp Val Gly Leu Leu Leu Pro Lys Leu Pro 
                325                 330                 335     


Asn Leu Ile Tyr His Lys Glu Ile Pro Phe Tyr Asn His Leu Asp Phe 
            340                 345                 350         


Ile Trp Ala Met Asp Ala Pro Gln Glu Val Tyr Asn Asp Ile Val Ser 
        355                 360                 365             


Met Ile Ser Glu Asp Lys Lys 
    370                 375 


<210>  7904
<211>  408
<212>  PRT
<213>  Homo Sapiens

<400>  7904

Met Phe Ser Asn Ala Asn Ser Arg Ser Lys Met Trp Leu Leu Leu Thr 
1               5                   10                  15      


Met Ala Ser Leu Ile Ser Val Leu Gly Thr Thr His Gly Leu Phe Gly 
            20                  25                  30          


Lys Leu His Pro Gly Ser Pro Glu Val Thr Met Asn Ile Ser Gln Met 
        35                  40                  45              


Ile Thr Tyr Trp Gly Tyr Pro Asn Glu Glu Tyr Glu Val Val Thr Glu 
    50                  55                  60                  


Asp Gly Tyr Ile Leu Glu Val Asn Arg Ile Pro Tyr Gly Lys Lys Asn 
65                  70                  75                  80  


Ser Gly Asn Thr Gly Gln Arg Pro Val Val Phe Leu Gln His Gly Leu 
                85                  90                  95      


Leu Ala Ser Ala Thr Asn Trp Ile Ser Asn Leu Pro Asn Asn Ser Leu 
            100                 105                 110         


Ala Phe Ile Leu Ala Asp Ala Gly Tyr Asp Val Trp Leu Gly Asn Ser 
        115                 120                 125             


Arg Gly Asn Thr Trp Ala Arg Arg Asn Leu Tyr Tyr Ser Pro Asp Ser 
    130                 135                 140                 


Val Glu Phe Trp Ala Phe Ser Phe Asp Glu Met Ala Lys Tyr Asp Leu 
145                 150                 155                 160 


Pro Ala Thr Ile Asp Phe Ile Val Lys Lys Thr Gly Gln Lys Gln Leu 
                165                 170                 175     


His Tyr Val Gly His Ser Gln Gly Thr Thr Ile Gly Phe Ile Ala Phe 
            180                 185                 190         


Ser Thr Asn Pro Ser Leu Ala Lys Arg Ile Lys Thr Phe Tyr Ala Leu 
        195                 200                 205             


Ala Pro Val Ala Thr Val Lys Tyr Thr Lys Ser Leu Ile Asn Lys Leu 
    210                 215                 220                 


Arg Phe Val Pro Gln Ser Leu Phe Lys Phe Ile Phe Gly Asp Lys Ile 
225                 230                 235                 240 


Phe Tyr Pro His Asn Phe Phe Asp Gln Phe Leu Ala Thr Glu Val Cys 
                245                 250                 255     


Ser Arg Glu Met Leu Asn Leu Leu Cys Ser Asn Ala Leu Phe Ile Ile 
            260                 265                 270         


Cys Gly Phe Asp Ser Lys Asn Phe Asn Thr Ser Arg Leu Asp Val Tyr 
        275                 280                 285             


Leu Ser His Asn Pro Ala Gly Thr Ser Val Gln Asn Met Phe His Trp 
    290                 295                 300                 


Thr Gln Ala Val Lys Ser Gly Lys Phe Gln Ala Tyr Asp Trp Gly Ser 
305                 310                 315                 320 


Pro Val Gln Asn Arg Met His Tyr Asp Gln Ser Gln Pro Pro Tyr Tyr 
                325                 330                 335     


Asn Val Thr Ala Met Asn Val Pro Ile Ala Val Trp Asn Gly Gly Lys 
            340                 345                 350         


Asp Leu Leu Ala Asp Pro Gln Asp Val Gly Leu Leu Leu Pro Lys Leu 
        355                 360                 365             


Pro Asn Leu Ile Tyr His Lys Glu Ile Pro Phe Tyr Asn His Leu Asp 
    370                 375                 380                 


Phe Ile Trp Ala Met Asp Ala Pro Gln Glu Val Tyr Asn Asp Ile Val 
385                 390                 395                 400 


Ser Met Ile Ser Glu Asp Lys Lys 
                405             


<210>  7905
<211>  365
<212>  PRT
<213>  Homo Sapiens

<400>  7905

Met Trp Leu Leu Leu Thr Met Ala Ser Leu Ile Ser Val Leu Gly Thr 
1               5                   10                  15      


Thr His Gly Leu Phe Gly Lys Leu His Pro Gly Ser Pro Glu Val Thr 
            20                  25                  30          


Met Asn Ile Ser Gln Met Ile Thr Tyr Trp Gly Tyr Pro Asn Glu Glu 
        35                  40                  45              


Tyr Glu Val Val Thr Glu Asp Gly Tyr Ile Leu Glu Val Asn Arg Ile 
    50                  55                  60                  


Pro Tyr Gly Lys Lys Asn Ser Gly Asn Thr Asp Ala Gly Tyr Asp Val 
65                  70                  75                  80  


Trp Leu Gly Asn Ser Arg Gly Asn Thr Trp Ala Arg Arg Asn Leu Tyr 
                85                  90                  95      


Tyr Ser Pro Asp Ser Val Glu Phe Trp Ala Phe Ser Phe Asp Glu Met 
            100                 105                 110         


Ala Lys Tyr Asp Leu Pro Ala Thr Ile Asp Phe Ile Val Lys Lys Thr 
        115                 120                 125             


Gly Gln Lys Gln Leu His Tyr Val Gly His Ser Gln Gly Thr Thr Ile 
    130                 135                 140                 


Gly Phe Ile Ala Phe Ser Thr Asn Pro Ser Leu Ala Lys Arg Ile Lys 
145                 150                 155                 160 


Thr Phe Tyr Ala Leu Ala Pro Val Ala Thr Val Lys Tyr Thr Lys Ser 
                165                 170                 175     


Leu Ile Asn Lys Leu Arg Phe Val Pro Gln Ser Leu Phe Lys Phe Ile 
            180                 185                 190         


Phe Gly Asp Lys Ile Phe Tyr Pro His Asn Phe Phe Asp Gln Phe Leu 
        195                 200                 205             


Ala Thr Glu Val Cys Ser Arg Glu Met Leu Asn Leu Leu Cys Ser Asn 
    210                 215                 220                 


Ala Leu Phe Ile Ile Cys Gly Phe Asp Ser Lys Asn Phe Asn Thr Ser 
225                 230                 235                 240 


Arg Leu Asp Val Tyr Leu Ser His Asn Pro Ala Gly Thr Ser Val Gln 
                245                 250                 255     


Asn Met Phe His Trp Thr Gln Ala Val Lys Ser Gly Lys Phe Gln Ala 
            260                 265                 270         


Tyr Asp Trp Gly Ser Pro Val Gln Asn Arg Met His Tyr Asp Gln Ser 
        275                 280                 285             


Gln Pro Pro Tyr Tyr Asn Val Thr Ala Met Asn Val Pro Ile Ala Val 
    290                 295                 300                 


Trp Asn Gly Gly Lys Asp Leu Leu Ala Asp Pro Gln Asp Val Gly Leu 
305                 310                 315                 320 


Leu Leu Pro Lys Leu Pro Asn Leu Ile Tyr His Lys Glu Ile Pro Phe 
                325                 330                 335     


Tyr Asn His Leu Asp Phe Ile Trp Ala Met Asp Ala Pro Gln Glu Val 
            340                 345                 350         


Tyr Asn Asp Ile Val Ser Met Ile Ser Glu Asp Lys Lys 
        355                 360                 365 


<210>  7906
<211>  398
<212>  PRT
<213>  Homo Sapiens

<400>  7906

Met Trp Leu Leu Leu Thr Met Ala Ser Leu Ile Ser Val Leu Gly Thr 
1               5                   10                  15      


Thr His Gly Leu Phe Gly Lys Leu His Pro Gly Ser Pro Glu Val Thr 
            20                  25                  30          


Met Asn Ile Ser Gln Met Ile Thr Tyr Trp Gly Tyr Pro Asn Glu Glu 
        35                  40                  45              


Tyr Glu Val Val Thr Glu Asp Gly Tyr Ile Leu Glu Val Asn Arg Ile 
    50                  55                  60                  


Pro Tyr Gly Lys Lys Asn Ser Gly Asn Thr Gly Gln Arg Pro Val Val 
65                  70                  75                  80  


Phe Leu Gln His Gly Leu Leu Ala Ser Ala Thr Asn Trp Ile Ser Asn 
                85                  90                  95      


Leu Pro Asn Asn Ser Leu Ala Phe Ile Leu Ala Asp Ala Gly Tyr Asp 
            100                 105                 110         


Val Trp Leu Gly Asn Ser Arg Gly Asn Thr Trp Ala Arg Arg Asn Leu 
        115                 120                 125             


Tyr Tyr Ser Pro Asp Ser Val Glu Phe Trp Ala Phe Ser Phe Asp Glu 
    130                 135                 140                 


Met Ala Lys Tyr Asp Leu Pro Ala Thr Ile Asp Phe Ile Val Lys Lys 
145                 150                 155                 160 


Thr Gly Gln Lys Gln Leu His Tyr Val Gly His Ser Gln Gly Thr Thr 
                165                 170                 175     


Ile Gly Phe Ile Ala Phe Ser Thr Asn Pro Ser Leu Ala Lys Arg Ile 
            180                 185                 190         


Lys Thr Phe Tyr Ala Leu Ala Pro Val Ala Thr Val Lys Tyr Thr Lys 
        195                 200                 205             


Ser Leu Ile Asn Lys Leu Arg Phe Val Pro Gln Ser Leu Phe Lys Phe 
    210                 215                 220                 


Ile Phe Gly Asp Lys Ile Phe Tyr Pro His Asn Phe Phe Asp Gln Phe 
225                 230                 235                 240 


Leu Ala Thr Glu Val Cys Ser Arg Glu Met Leu Asn Leu Leu Cys Ser 
                245                 250                 255     


Asn Ala Leu Phe Ile Ile Cys Gly Phe Asp Ser Lys Asn Phe Asn Thr 
            260                 265                 270         


Ser Arg Leu Asp Val Tyr Leu Ser His Asn Pro Ala Gly Thr Ser Val 
        275                 280                 285             


Gln Asn Met Phe His Trp Thr Gln Ala Val Lys Ser Gly Lys Phe Gln 
    290                 295                 300                 


Ala Tyr Asp Trp Gly Ser Pro Val Gln Asn Arg Met His Tyr Asp Gln 
305                 310                 315                 320 


Ser Gln Pro Pro Tyr Tyr Asn Val Thr Ala Met Asn Val Pro Ile Ala 
                325                 330                 335     


Val Trp Asn Gly Gly Lys Asp Leu Leu Ala Asp Pro Gln Asp Val Gly 
            340                 345                 350         


Leu Leu Leu Pro Lys Leu Pro Asn Leu Ile Tyr His Lys Glu Ile Pro 
        355                 360                 365             


Phe Tyr Asn His Leu Asp Phe Ile Trp Ala Met Asp Ala Pro Gln Glu 
    370                 375                 380                 


Val Tyr Asn Asp Ile Val Ser Met Ile Ser Glu Asp Lys Lys 
385                 390                 395             


<210>  7907
<211>  188
<212>  PRT
<213>  Homo Sapiens

<400>  7907

Leu Cys Tyr Cys Phe Ala Ala Gly Ser Pro Val Pro Phe Gly Pro Glu 
1               5                   10                  15      


Gly Arg Leu Glu Asp Lys Leu His Lys Pro Lys Ala Thr Gln Thr Glu 
            20                  25                  30          


Val Lys Pro Ser Val Arg Phe Asn Leu Arg Thr Ser Lys Asp Pro Glu 
        35                  40                  45              


His Glu Gly Cys Tyr Leu Ser Val Gly His Ser Gln Pro Leu Glu Asp 
    50                  55                  60                  


Cys Ser Phe Asn Met Thr Ala Lys Thr Phe Phe Ile Ile His Gly Trp 
65                  70                  75                  80  


Thr Met Ser Gly Ile Phe Glu Asn Trp Leu His Lys Leu Val Ser Ala 
                85                  90                  95      


Leu His Thr Arg Glu Lys Asp Ala Asn Val Val Val Val Asp Trp Leu 
            100                 105                 110         


Pro Leu Ala His Gln Leu Tyr Thr Asp Ala Val Asn Asn Thr Arg Val 
        115                 120                 125             


Val Gly His Ser Ile Ala Arg Met Leu Asp Trp Leu Gln Val Leu Gly 
    130                 135                 140                 


Asp Glu Arg Glu Ser Pro Val Thr Ser Arg Ile Ser Asn Pro Ile Phe 
145                 150                 155                 160 


Leu Arg Asn Ala Gly His Ala Ser Val Ala Met Asn Phe Trp Ser Leu 
                165                 170                 175     


Ile Lys Ile Phe Glu Ile Lys Ser Phe Ile Glu Leu 
            180                 185             


<210>  7908
<211>  390
<212>  PRT
<213>  Homo Sapiens

<400>  7908

Met Leu Ser Phe Ser Arg Asp Arg Leu Pro Ser Gly Arg Arg Val Ser 
1               5                   10                  15      


Gly Lys Cys Pro Pro Pro Pro Leu Gly Met Ala Val Gly Arg Gly Gly 
            20                  25                  30          


Ser Gly Cys Pro Glu Glu Gly Ser Gly Arg Lys Leu Glu Leu Leu Glu 
        35                  40                  45              


Ser Gln Leu Pro Ala Glu Arg Ala Arg Glu Glu Ala Gly Pro Ser Val 
    50                  55                  60                  


Arg Arg Pro Arg Asp Lys Leu His Lys Pro Lys Ala Thr Gln Thr Glu 
65                  70                  75                  80  


Val Lys Pro Ser Val Arg Phe Asn Leu Arg Thr Ser Lys Asp Pro Glu 
                85                  90                  95      


His Glu Gly Cys Tyr Leu Ser Val Gly His Ser Gln Pro Leu Glu Asp 
            100                 105                 110         


Cys Ser Phe Asn Met Thr Ala Lys Thr Phe Phe Ile Ile His Gly Trp 
        115                 120                 125             


Thr Met Ser Gly Ile Phe Glu Asn Trp Leu His Lys Leu Val Ser Ala 
    130                 135                 140                 


Leu His Thr Arg Glu Lys Asp Ala Asn Val Val Val Val Asp Trp Leu 
145                 150                 155                 160 


Pro Leu Ala His Gln Leu Tyr Thr Asp Ala Val Asn Asn Thr Arg Val 
                165                 170                 175     


Val Gly His Ser Ile Ala Arg Met Leu Asp Trp Leu Gln Glu Lys Asp 
            180                 185                 190         


Asp Phe Ser Leu Gly Asn Val His Leu Ile Gly Tyr Ser Leu Gly Ala 
        195                 200                 205             


His Val Ala Gly Tyr Ala Gly Asn Phe Val Lys Gly Thr Val Gly Arg 
    210                 215                 220                 


Ile Thr Gly Leu Asp Pro Ala Gly Pro Met Phe Glu Gly Ala Asp Ile 
225                 230                 235                 240 


His Lys Arg Leu Ser Pro Asp Asp Ala Asp Phe Val Asp Val Leu His 
                245                 250                 255     


Thr Tyr Thr Arg Ser Phe Gly Leu Ser Ile Gly Ile Gln Met Pro Val 
            260                 265                 270         


Gly His Ile Asp Ile Tyr Pro Asn Gly Gly Asp Phe Gln Pro Gly Cys 
        275                 280                 285             


Gly Leu Asn Asp Val Leu Gly Ser Ile Ala Tyr Gly Thr Ile Thr Glu 
    290                 295                 300                 


Val Val Lys Cys Glu His Glu Arg Ala Val His Leu Phe Val Asp Ser 
305                 310                 315                 320 


Leu Val Asn Gln Asp Lys Pro Ser Phe Ala Phe Gln Cys Thr Asp Ser 
                325                 330                 335     


Asn Arg Phe Lys Lys Gly Ile Cys Leu Ser Cys Arg Lys Asn Arg Cys 
            340                 345                 350         


Asn Ser Ile Gly Tyr Asn Ala Lys Lys Met Arg Asn Lys Arg Asn Ser 
        355                 360                 365             


Lys Met Tyr Leu Lys Thr Arg Ala Gly Met Pro Phe Arg Gly Asn Leu 
    370                 375                 380                 


Gln Ser Leu Glu Cys Pro 
385                 390 


<210>  7909
<211>  426
<212>  PRT
<213>  Homo Sapiens

<400>  7909

Met Ser Asn Ser Val Pro Leu Leu Cys Phe Trp Ser Leu Cys Tyr Cys 
1               5                   10                  15      


Phe Ala Ala Gly Ser Pro Val Pro Phe Gly Pro Glu Gly Arg Leu Glu 
            20                  25                  30          


Asp Lys Leu His Lys Pro Lys Ala Thr Gln Thr Glu Val Lys Pro Ser 
        35                  40                  45              


Val Arg Phe Asn Leu Arg Thr Ser Lys Asp Pro Glu His Glu Gly Cys 
    50                  55                  60                  


Tyr Leu Ser Val Gly His Ser Gln Pro Leu Glu Asp Cys Ser Phe Asn 
65                  70                  75                  80  


Met Thr Ala Lys Thr Phe Phe Ile Ile His Gly Trp Thr Met Ser Gly 
                85                  90                  95      


Ile Phe Glu Asn Trp Leu His Lys Leu Val Ser Ala Leu His Thr Arg 
            100                 105                 110         


Glu Lys Asp Ala Asn Val Val Val Val Asp Trp Leu Pro Leu Ala His 
        115                 120                 125             


Gln Leu Tyr Thr Asp Ala Val Asn Asn Thr Arg Val Val Gly His Ser 
    130                 135                 140                 


Ile Ala Arg Met Leu Asp Trp Leu Gln Glu Lys Asp Asp Phe Ser Leu 
145                 150                 155                 160 


Gly Asn Val His Leu Ile Gly Tyr Ser Leu Gly Ala His Val Ala Gly 
                165                 170                 175     


Tyr Ala Gly Asn Phe Val Lys Gly Thr Val Gly Arg Ile Thr Ala Ile 
            180                 185                 190         


Thr Glu Val Val Lys Cys Glu His Glu Arg Ala Val His Leu Phe Val 
        195                 200                 205             


Asp Ser Leu Val Asn Gln Asp Lys Pro Ser Phe Ala Phe Gln Cys Thr 
    210                 215                 220                 


Asp Ser Asn Arg Phe Lys Lys Gly Ile Cys Leu Ser Cys Arg Lys Asn 
225                 230                 235                 240 


Arg Cys Asn Ser Ile Gly Tyr Asn Ala Lys Lys Met Arg Asn Lys Arg 
                245                 250                 255     


Asn Ser Lys Met Tyr Leu Lys Thr Arg Ala Gly Met Pro Phe Arg Val 
            260                 265                 270         


Tyr His Tyr Gln Met Lys Ile His Val Phe Ser Tyr Lys Asn Met Gly 
        275                 280                 285             


Glu Ile Glu Pro Thr Phe Tyr Val Thr Leu Tyr Gly Thr Asn Ala Asp 
    290                 295                 300                 


Ser Gln Thr Leu Pro Leu Glu Ile Val Glu Arg Ile Glu Gln Asn Ala 
305                 310                 315                 320 


Thr Asn Thr Phe Leu Val Tyr Thr Glu Glu Asp Leu Gly Asp Leu Leu 
                325                 330                 335     


Lys Ile Gln Leu Thr Trp Glu Gly Ala Ser Gln Ser Trp Tyr Asn Leu 
            340                 345                 350         


Trp Lys Glu Phe Arg Ser Tyr Leu Ser Gln Pro Arg Asn Pro Gly Arg 
        355                 360                 365             


Glu Leu Asn Ile Arg Arg Ile Arg Val Lys Ser Gly Glu Thr Gln Arg 
    370                 375                 380                 


Lys Leu Thr Phe Cys Thr Glu Asp Pro Glu Asn Thr Ser Ile Ser Pro 
385                 390                 395                 400 


Gly Arg Glu Leu Trp Phe Arg Lys Cys Arg Asp Gly Trp Arg Met Lys 
                405                 410                 415     


Asn Glu Thr Ser Pro Thr Val Glu Leu Pro 
            420                 425     


<210>  7910
<211>  500
<212>  PRT
<213>  Homo Sapiens

<400>  7910

Met Ser Asn Ser Val Pro Leu Leu Cys Phe Trp Ser Leu Cys Tyr Cys 
1               5                   10                  15      


Phe Ala Ala Gly Ser Pro Val Pro Phe Gly Pro Glu Gly Arg Leu Glu 
            20                  25                  30          


Asp Lys Leu His Lys Pro Lys Ala Thr Gln Thr Glu Val Lys Pro Ser 
        35                  40                  45              


Val Arg Phe Asn Leu Arg Thr Ser Lys Asp Pro Glu His Glu Gly Cys 
    50                  55                  60                  


Tyr Leu Ser Val Gly His Ser Gln Pro Leu Glu Asp Cys Ser Phe Asn 
65                  70                  75                  80  


Met Thr Ala Lys Thr Phe Phe Ile Ile His Gly Trp Thr Met Ser Gly 
                85                  90                  95      


Ile Phe Glu Asn Trp Leu His Lys Leu Val Ser Ala Leu His Thr Arg 
            100                 105                 110         


Glu Lys Asp Ala Asn Val Val Val Val Asp Trp Leu Pro Leu Ala His 
        115                 120                 125             


Gln Leu Tyr Thr Asp Ala Val Asn Asn Thr Arg Val Val Gly His Ser 
    130                 135                 140                 


Ile Ala Arg Met Leu Asp Trp Leu Gln Glu Lys Asp Asp Phe Ser Leu 
145                 150                 155                 160 


Gly Asn Val His Leu Ile Gly Tyr Ser Leu Gly Ala His Val Ala Gly 
                165                 170                 175     


Tyr Ala Gly Asn Phe Val Lys Gly Thr Val Gly Arg Ile Thr Gly Leu 
            180                 185                 190         


Asp Pro Ala Gly Pro Met Phe Glu Gly Ala Asp Ile His Lys Arg Leu 
        195                 200                 205             


Ser Pro Asp Asp Ala Asp Phe Val Asp Val Leu His Thr Tyr Thr Arg 
    210                 215                 220                 


Ser Phe Gly Leu Ser Ile Gly Ile Gln Met Pro Val Gly His Ile Asp 
225                 230                 235                 240 


Ile Tyr Pro Asn Gly Gly Asp Phe Gln Pro Gly Cys Gly Leu Asn Asp 
                245                 250                 255     


Val Leu Gly Ser Ile Ala Tyr Gly Thr Ile Thr Glu Val Val Lys Cys 
            260                 265                 270         


Glu His Glu Arg Ala Val His Leu Phe Val Asp Ser Leu Val Asn Gln 
        275                 280                 285             


Asp Lys Pro Ser Phe Ala Phe Gln Cys Thr Asp Ser Asn Arg Phe Lys 
    290                 295                 300                 


Lys Gly Ile Cys Leu Ser Cys Arg Lys Asn Arg Cys Asn Ser Ile Gly 
305                 310                 315                 320 


Tyr Asn Ala Lys Lys Met Arg Asn Lys Arg Asn Ser Lys Met Tyr Leu 
                325                 330                 335     


Lys Thr Arg Ala Gly Met Pro Phe Arg Val Tyr His Tyr Gln Met Lys 
            340                 345                 350         


Ile His Val Phe Ser Tyr Lys Asn Met Gly Glu Ile Glu Pro Thr Phe 
        355                 360                 365             


Tyr Val Thr Leu Tyr Gly Thr Asn Ala Asp Ser Gln Thr Leu Pro Leu 
    370                 375                 380                 


Glu Ile Val Glu Arg Ile Glu Gln Asn Ala Thr Asn Thr Phe Leu Val 
385                 390                 395                 400 


Tyr Thr Glu Glu Asp Leu Gly Asp Leu Leu Lys Ile Gln Leu Thr Trp 
                405                 410                 415     


Glu Gly Ala Ser Gln Ser Trp Tyr Asn Leu Trp Lys Glu Phe Arg Ser 
            420                 425                 430         


Tyr Leu Ser Gln Pro Arg Asn Pro Gly Arg Glu Leu Asn Ile Arg Arg 
        435                 440                 445             


Ile Arg Val Lys Ser Gly Glu Thr Gln Arg Lys Leu Thr Phe Cys Thr 
    450                 455                 460                 


Glu Asp Pro Glu Asn Thr Ser Ile Ser Pro Gly Arg Glu Leu Trp Phe 
465                 470                 475                 480 


Arg Lys Cys Arg Asp Gly Trp Arg Met Lys Asn Glu Thr Ser Pro Thr 
                485                 490                 495     


Val Glu Leu Pro 
            500 


<210>  7911
<211>  354
<212>  PRT
<213>  Homo Sapiens

<400>  7911

Met Ser Asn Ser Val Pro Leu Leu Cys Phe Trp Ser Leu Cys Tyr Cys 
1               5                   10                  15      


Phe Ala Ala Gly Ser Pro Val Pro Phe Gly Pro Glu Gly Arg Leu Glu 
            20                  25                  30          


Asp Lys Leu His Lys Pro Lys Ala Thr Gln Thr Glu Val Lys Pro Ser 
        35                  40                  45              


Val Arg Phe Asn Leu Arg Thr Ser Lys Asp Pro Glu His Glu Gly Cys 
    50                  55                  60                  


Tyr Leu Ser Val Gly His Ser Gln Pro Leu Glu Asp Cys Ser Phe Asn 
65                  70                  75                  80  


Met Thr Ala Lys Thr Phe Phe Ile Ile His Gly Trp Thr Met Ser Gly 
                85                  90                  95      


Ile Phe Glu Asn Trp Leu His Lys Leu Val Ser Ala Leu His Thr Arg 
            100                 105                 110         


Glu Lys Asp Ala Asn Val Val Val Val Asp Trp Leu Pro Leu Ala His 
        115                 120                 125             


Gln Leu Tyr Thr Asp Ala Val Asn Asn Thr Arg Val Val Gly His Ser 
    130                 135                 140                 


Ile Ala Arg Met Leu Asp Trp Leu Gln Glu Lys Asp Asp Phe Ser Leu 
145                 150                 155                 160 


Gly Asn Val His Leu Ile Gly Tyr Ser Leu Gly Ala His Val Ala Gly 
                165                 170                 175     


Tyr Ala Gly Asn Phe Val Lys Gly Thr Val Gly Arg Ile Thr Gly Leu 
            180                 185                 190         


Asp Pro Ala Gly Pro Met Phe Glu Gly Ala Asp Ile His Lys Arg Leu 
        195                 200                 205             


Ser Pro Asp Asp Ala Asp Phe Val Asp Val Leu His Thr Tyr Thr Arg 
    210                 215                 220                 


Ser Phe Gly Leu Ser Ile Gly Ile Gln Met Pro Val Gly His Ile Asp 
225                 230                 235                 240 


Ile Tyr Pro Asn Gly Gly Asp Phe Gln Pro Gly Cys Gly Leu Asn Asp 
                245                 250                 255     


Val Leu Gly Ser Ile Ala Tyr Gly Thr Ile Thr Glu Val Val Lys Cys 
            260                 265                 270         


Glu His Glu Arg Ala Val His Leu Phe Val Asp Ser Leu Val Asn Gln 
        275                 280                 285             


Asp Lys Pro Ser Phe Ala Phe Gln Cys Thr Asp Ser Asn Arg Phe Lys 
    290                 295                 300                 


Lys Gly Ile Cys Leu Ser Cys Arg Lys Asn Arg Cys Asn Ser Ile Gly 
305                 310                 315                 320 


Tyr Asn Ala Lys Lys Met Arg Asn Lys Arg Asn Ser Lys Met Tyr Leu 
                325                 330                 335     


Lys Thr Arg Ala Gly Met Pro Phe Arg Gly Asn Leu Gln Ser Leu Glu 
            340                 345                 350         


Cys Pro 
        


<210>  7912
<211>  24
<212>  PRT
<213>  Homo Sapiens

<400>  7912

Met Thr Ala Lys Thr Phe Phe Ile Ile His Gly Trp Thr Met Ser Gly 
1               5                   10                  15      


Ile Phe Glu Asn Trp Leu His Lys 
            20                  


<210>  7913
<211>  417
<212>  PRT
<213>  Homo Sapiens

<400>  7913

Met Leu Arg Phe Tyr Leu Phe Ile Ser Leu Leu Cys Leu Ser Arg Ser 
1               5                   10                  15      


Asp Ala Glu Glu Thr Cys Pro Ser Phe Thr Arg Leu Ser Phe His Ser 
            20                  25                  30          


Ala Val Val Gly Thr Gly Leu Asn Val Arg Leu Met Leu Tyr Thr Arg 
        35                  40                  45              


Lys Asn Leu Thr Cys Ala Gln Thr Ile Asn Ser Ser Ala Phe Gly Asn 
    50                  55                  60                  


Leu Asn Val Thr Lys Lys Thr Thr Phe Ile Val His Gly Phe Arg Pro 
65                  70                  75                  80  


Thr Gly Ser Pro Pro Val Trp Met Asp Asp Leu Val Lys Gly Leu Leu 
                85                  90                  95      


Ser Val Glu Asp Met Asn Val Val Val Val Asp Trp Asn Arg Gly Ala 
            100                 105                 110         


Thr Thr Leu Ile Tyr Thr His Ala Ser Ser Lys Thr Arg Lys Val Ala 
        115                 120                 125             


Met Val Leu Lys Glu Phe Ile Asp Gln Met Leu Ala Glu Gly Ala Ser 
    130                 135                 140                 


Leu Asp Asp Ile Tyr Met Ile Gly Val Ser Leu Gly Ala His Ile Ser 
145                 150                 155                 160 


Gly Phe Val Gly Glu Met Tyr Asp Gly Trp Leu Gly Arg Ile Thr Ala 
                165                 170                 175     


Leu Gly Tyr Lys Glu Pro Leu Gly Asn Ile Asp Phe Tyr Pro Asn Gly 
            180                 185                 190         


Gly Leu Asp Gln Pro Gly Cys Pro Lys Thr Ile Leu Gly Gly Phe Gln 
        195                 200                 205             


Tyr Phe Lys Cys Asp His Gln Arg Ser Val Tyr Leu Tyr Leu Ser Ser 
    210                 215                 220                 


Leu Arg Glu Ser Cys Thr Ile Thr Ala Tyr Pro Cys Asp Ser Tyr Gln 
225                 230                 235                 240 


Asp Tyr Arg Asn Gly Lys Cys Val Ser Cys Gly Thr Ser Gln Lys Glu 
                245                 250                 255     


Ser Cys Pro Leu Leu Gly Tyr Tyr Ala Asp Asn Trp Lys Asp His Leu 
            260                 265                 270         


Arg Gly Lys Asp Pro Pro Met Thr Lys Ala Phe Phe Asp Thr Ala Glu 
        275                 280                 285             


Glu Ser Pro Phe Cys Met Tyr His Tyr Phe Val Asp Ile Ile Thr Trp 
    290                 295                 300                 


Asn Lys Asn Val Arg Arg Gly Asp Ile Thr Ile Lys Leu Arg Asp Lys 
305                 310                 315                 320 


Ala Gly Asn Thr Thr Glu Ser Lys Ile Asn His Glu Pro Thr Thr Phe 
                325                 330                 335     


Gln Lys Tyr His Gln Val Ser Leu Leu Ala Arg Phe Asn Gln Asp Leu 
            340                 345                 350         


Asp Lys Val Ala Ala Ile Ser Leu Met Phe Ser Thr Gly Ser Leu Ile 
        355                 360                 365             


Gly Pro Arg Tyr Lys Leu Arg Ile Leu Arg Met Lys Leu Arg Ser Leu 
    370                 375                 380                 


Ala His Pro Glu Arg Pro Gln Leu Cys Arg Tyr Asp Leu Val Leu Met 
385                 390                 395                 400 


Glu Asn Val Glu Thr Val Phe Gln Pro Ile Leu Cys Pro Glu Leu Gln 
                405                 410                 415     


Leu 
    


<210>  7914
<211>  451
<212>  PRT
<213>  Homo Sapiens

<400>  7914

Met Leu Arg Phe Tyr Leu Phe Ile Ser Leu Leu Cys Leu Ser Arg Ser 
1               5                   10                  15      


Asp Ala Glu Glu Thr Cys Pro Ser Phe Thr Arg Leu Ser Phe His Ser 
            20                  25                  30          


Ala Val Val Gly Thr Gly Leu Asn Val Arg Leu Met Leu Tyr Thr Arg 
        35                  40                  45              


Lys Asn Leu Thr Cys Ala Gln Thr Ile Asn Ser Ser Ala Phe Gly Asn 
    50                  55                  60                  


Leu Asn Val Thr Lys Lys Thr Thr Phe Ile Val His Gly Phe Arg Pro 
65                  70                  75                  80  


Thr Gly Ser Pro Pro Val Trp Met Asp Asp Leu Val Lys Gly Leu Leu 
                85                  90                  95      


Ser Val Glu Asp Met Asn Val Val Val Val Asp Trp Asn Arg Gly Ala 
            100                 105                 110         


Thr Thr Leu Ile Tyr Thr His Ala Ser Ser Lys Thr Arg Lys Val Ala 
        115                 120                 125             


Met Val Leu Lys Glu Phe Ile Asp Gln Met Leu Ala Glu Gly Ala Ser 
    130                 135                 140                 


Leu Asp Asp Ile Tyr Met Ile Gly Val Ser Leu Gly Ala His Ile Ser 
145                 150                 155                 160 


Gly Phe Val Gly Glu Met Tyr Asp Gly Trp Leu Gly Arg Ile Thr Gly 
                165                 170                 175     


Leu Asp Pro Ala Gly Pro Leu Phe Asn Gly Lys Pro His Gln Asp Arg 
            180                 185                 190         


Leu Asp Pro Ser Asp Ala Gln Phe Val Asp Val Ile His Ser Asp Thr 
        195                 200                 205             


Asp Ala Leu Gly Tyr Lys Glu Pro Leu Gly Asn Ile Asp Phe Tyr Pro 
    210                 215                 220                 


Asn Gly Gly Leu Asp Gln Pro Gly Cys Pro Lys Thr Ile Leu Gly Gly 
225                 230                 235                 240 


Phe Gln Tyr Phe Lys Cys Asp His Gln Arg Ser Val Tyr Leu Tyr Leu 
                245                 250                 255     


Ser Ser Leu Arg Glu Ser Cys Thr Ile Thr Ala Tyr Pro Cys Asp Ser 
            260                 265                 270         


Tyr Gln Asp Tyr Arg Asn Gly Lys Cys Val Ser Cys Gly Thr Ser Gln 
        275                 280                 285             


Lys Glu Ser Cys Pro Leu Leu Gly Tyr Tyr Ala Asp Asn Trp Lys Asp 
    290                 295                 300                 


His Leu Arg Gly Lys Asp Pro Pro Met Thr Lys Ala Phe Phe Asp Thr 
305                 310                 315                 320 


Ala Glu Glu Ser Pro Phe Cys Met Tyr His Tyr Phe Val Asp Ile Ile 
                325                 330                 335     


Thr Trp Asn Lys Asn Val Arg Arg Gly Asp Ile Thr Ile Lys Leu Arg 
            340                 345                 350         


Asp Lys Ala Gly Asn Thr Thr Glu Ser Lys Ile Asn His Glu Pro Thr 
        355                 360                 365             


Thr Phe Gln Lys Tyr His Gln Val Ser Leu Leu Ala Arg Phe Asn Gln 
    370                 375                 380                 


Asp Leu Asp Lys Val Ala Ala Ile Ser Leu Met Phe Ser Thr Gly Ser 
385                 390                 395                 400 


Leu Ile Gly Pro Arg Tyr Lys Leu Arg Ile Leu Arg Met Lys Leu Arg 
                405                 410                 415     


Ser Leu Ala His Pro Glu Arg Pro Gln Leu Cys Arg Tyr Asp Leu Val 
            420                 425                 430         


Leu Met Glu Asn Val Glu Thr Val Phe Gln Pro Ile Leu Cys Pro Glu 
        435                 440                 445             


Leu Gln Leu 
    450     


<210>  7915
<211>  47
<212>  PRT
<213>  Homo Sapiens

<400>  7915

Met Leu Arg Phe Tyr Leu Phe Ile Ser Leu Leu Cys Leu Ser Arg Ser 
1               5                   10                  15      


Asp Ala Ser Leu Asp Met Asn Glu Glu Ser Pro Leu Phe Glu Glu Gly 
            20                  25                  30          


Phe Leu Gln Ser Glu Ile Trp Glu Ile Lys Leu Ile Pro Pro Lys 
        35                  40                  45          


<210>  7916
<211>  86
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7916

Xaa Asp Ile Tyr Met Ile Gly Val Ser Leu Gly Ala His Ile Ser Gly 
1               5                   10                  15      


Phe Val Gly Glu Met Tyr Asp Gly Trp Leu Gly Arg Ile Thr Gly Phe 
            20                  25                  30          


Gln Tyr Phe Lys Cys Asp His Gln Arg Ser Val Tyr Leu Tyr Leu Ser 
        35                  40                  45              


Ser Leu Arg Glu Ser Cys Thr Ile Thr Ala Tyr Pro Cys Asp Ser Tyr 
    50                  55                  60                  


Gln Asp Tyr Arg Asn Gly Lys Cys Val Ser Cys Gly Thr Ser Gln Lys 
65                  70                  75                  80  


Glu Ser Cys Pro Leu Leu 
                85      


<210>  7917
<211>  73
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7917

Xaa Ser Pro Phe Cys Met Tyr His Tyr Phe Val Asp Ile Ile Thr Trp 
1               5                   10                  15      


Asn Lys Asn Val Arg Arg Gly Asp Ile Thr Ile Lys Leu Arg Asp Lys 
            20                  25                  30          


Ala Gly Asn Thr Thr Glu Ser Lys Ile Asn Gln Ile Ser Asn Arg Pro 
        35                  40                  45              


Lys Val Gln Ala Gln Asp Ser Pro Asn Glu Val Lys Val Pro Cys Pro 
    50                  55                  60                  


Ser Gly Glu Ala Ser Ala Val Ser Val 
65                  70              


<210>  7918
<211>  399
<212>  PRT
<213>  Homo Sapiens

<400>  7918

Met Trp Gln Leu Leu Ala Ala Ala Cys Trp Met Leu Leu Leu Gly Ser 
1               5                   10                  15      


Met Tyr Gly Tyr Asp Lys Lys Gly Asn Asn Ala Asn Pro Glu Ala Asn 
            20                  25                  30          


Met Asn Ile Ser Gln Ile Ile Ser Tyr Trp Gly Tyr Pro Tyr Glu Glu 
        35                  40                  45              


Tyr Asp Val Thr Thr Lys Asp Gly Tyr Ile Leu Gly Ile Tyr Arg Ile 
    50                  55                  60                  


Pro His Gly Arg Gly Cys Pro Gly Arg Thr Ala Pro Lys Pro Ala Val 
65                  70                  75                  80  


Tyr Leu Gln His Gly Leu Ile Ala Ser Ala Ser Asn Trp Ile Cys Asn 
                85                  90                  95      


Leu Pro Asn Asn Ser Leu Ala Phe Leu Leu Ala Asp Ser Gly Tyr Asp 
            100                 105                 110         


Val Trp Leu Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys His Leu 
        115                 120                 125             


Lys Leu Ser Pro Lys Ser Pro Glu Tyr Trp Ala Phe Ser Leu Asp Glu 
    130                 135                 140                 


Met Ala Lys Tyr Asp Leu Pro Ala Thr Ile Asn Phe Ile Ile Glu Lys 
145                 150                 155                 160 


Thr Gly Gln Lys Arg Leu Tyr Tyr Val Gly His Ser Gln Gly Thr Thr 
                165                 170                 175     


Ile Ala Phe Ile Ala Phe Ser Thr Asn Pro Glu Leu Ala Lys Lys Ile 
            180                 185                 190         


Lys Ile Phe Phe Ala Leu Ala Pro Val Val Thr Val Lys Tyr Thr Gln 
        195                 200                 205             


Ser Pro Met Lys Lys Leu Thr Thr Leu Ser Arg Arg Val Val Lys Val 
    210                 215                 220                 


Leu Phe Gly Asp Lys Met Phe His Pro His Thr Leu Phe Asp Gln Phe 
225                 230                 235                 240 


Ile Ala Thr Lys Val Cys Asn Arg Lys Leu Phe Arg Arg Ile Cys Ser 
                245                 250                 255     


Asn Phe Leu Phe Thr Leu Ser Gly Phe Asp Pro Gln Asn Leu Asn Met 
            260                 265                 270         


Ser Arg Leu Asp Val Tyr Leu Ser His Asn Pro Ala Gly Thr Ser Val 
        275                 280                 285             


Gln Asn Met Leu His Trp Ala Gln Ala Val Asn Ser Gly Gln Leu Gln 
    290                 295                 300                 


Ala Phe Asp Trp Gly Asn Ser Asp Gln Asn Met Met His Phe His Gln 
305                 310                 315                 320 


Leu Thr Pro Pro Leu Tyr Asn Ile Thr Lys Met Glu Val Pro Thr Ala 
                325                 330                 335     


Ile Trp Asn Gly Gly Gln Asp Ile Val Ala Asp Pro Lys Asp Val Glu 
            340                 345                 350         


Asn Leu Leu Pro Gln Ile Ala Asn Leu Ile Tyr Tyr Lys Leu Ile Pro 
        355                 360                 365             


His Tyr Asn His Val Asp Phe Tyr Leu Gly Glu Asp Ala Pro Gln Glu 
    370                 375                 380                 


Ile Tyr Gln Asp Leu Ile Ile Leu Met Glu Glu Tyr Leu Gln Asn 
385                 390                 395                 


<210>  7919
<211>  423
<212>  PRT
<213>  Homo Sapiens

<400>  7919

Met Leu Glu Thr Leu Ser Arg Gln Trp Ile Val Ser His Arg Met Glu 
1               5                   10                  15      


Met Trp Leu Leu Ile Leu Val Ala Tyr Met Phe Gln Arg Asn Val Asn 
            20                  25                  30          


Ser Val His Met Pro Thr Lys Ala Val Asp Pro Glu Ala Phe Met Asn 
        35                  40                  45              


Ile Ser Glu Ile Ile Gln His Gln Gly Tyr Pro Cys Glu Glu Tyr Glu 
    50                  55                  60                  


Val Ala Thr Glu Asp Gly Tyr Ile Leu Ser Val Asn Arg Ile Pro Arg 
65                  70                  75                  80  


Gly Leu Val Gln Pro Lys Lys Thr Gly Ser Arg Pro Val Val Leu Leu 
                85                  90                  95      


Gln His Gly Leu Val Gly Gly Ala Ser Asn Trp Ile Ser Asn Leu Pro 
            100                 105                 110         


Asn Asn Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp Val Trp 
        115                 120                 125             


Met Gly Asn Ser Arg Gly Asn Ala Trp Ser Arg Lys His Lys Thr Leu 
    130                 135                 140                 


Ser Ile Asp Gln Asp Glu Phe Trp Ala Phe Ser Tyr Asp Glu Met Ala 
145                 150                 155                 160 


Arg Phe Asp Leu Pro Ala Val Ile Asn Phe Ile Leu Gln Lys Thr Gly 
                165                 170                 175     


Gln Glu Lys Ile Tyr Tyr Val Gly Tyr Ser Gln Gly Thr Thr Met Gly 
            180                 185                 190         


Phe Ile Ala Phe Ser Thr Met Pro Glu Leu Ala Gln Lys Ile Lys Met 
        195                 200                 205             


Tyr Phe Ala Leu Ala Pro Ile Ala Thr Val Lys His Ala Lys Ser Pro 
    210                 215                 220                 


Gly Thr Lys Phe Leu Leu Leu Pro Asp Met Met Ile Lys Gly Leu Phe 
225                 230                 235                 240 


Gly Lys Lys Glu Phe Leu Tyr Gln Thr Arg Phe Leu Arg Gln Leu Val 
                245                 250                 255     


Ile Tyr Leu Cys Gly Gln Val Ile Leu Asp Gln Ile Cys Ser Asn Ile 
            260                 265                 270         


Met Leu Leu Leu Gly Gly Phe Asn Thr Asn Asn Met Asn Met Ser Arg 
        275                 280                 285             


Ala Ser Val Tyr Ala Ala His Thr Leu Ala Gly Thr Ser Val Gln Asn 
    290                 295                 300                 


Ile Leu His Trp Ser Gln Ala Val Asn Ser Gly Glu Leu Arg Ala Phe 
305                 310                 315                 320 


Asp Trp Gly Ser Glu Thr Lys Asn Leu Glu Lys Cys Asn Gln Pro Thr 
                325                 330                 335     


Pro Val Arg Tyr Arg Val Arg Asp Met Thr Val Pro Thr Ala Met Trp 
            340                 345                 350         


Thr Gly Gly Gln Asp Trp Leu Ser Asn Pro Glu Asp Val Lys Met Leu 
        355                 360                 365             


Leu Ser Glu Val Thr Asn Leu Ile Tyr His Lys Asn Ile Pro Glu Trp 
    370                 375                 380                 


Ala His Val Asp Phe Ile Trp Gly Leu Asp Ala Pro His Arg Met Tyr 
385                 390                 395                 400 


Asn Glu Ile Ile His Leu Met Gln Gln Glu Glu Thr Asn Leu Ser Gln 
                405                 410                 415     


Gly Arg Cys Glu Ala Val Leu 
            420             


<210>  7920
<211>  383
<212>  PRT
<213>  Homo Sapiens

<400>  7920

Met Thr Arg Pro Leu Asp Arg Lys Gln Ser Glu Ile Ile Gln His Gln 
1               5                   10                  15      


Gly Tyr Pro Cys Glu Glu Tyr Glu Val Ala Thr Glu Asp Gly Tyr Ile 
            20                  25                  30          


Leu Ser Val Asn Arg Ile Pro Arg Gly Leu Val Gln Pro Lys Lys Thr 
        35                  40                  45              


Gly Ser Arg Pro Val Val Leu Leu Gln His Gly Leu Val Gly Gly Ala 
    50                  55                  60                  


Ser Asn Trp Ile Ser Asn Leu Pro Asn Asn Ser Leu Gly Phe Ile Leu 
65                  70                  75                  80  


Ala Asp Ala Gly Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Ala 
                85                  90                  95      


Trp Ser Arg Lys His Lys Thr Leu Ser Ile Asp Gln Asp Glu Phe Trp 
            100                 105                 110         


Ala Phe Ser Tyr Asp Glu Met Ala Arg Phe Asp Leu Pro Ala Val Ile 
        115                 120                 125             


Asn Phe Ile Leu Gln Lys Thr Gly Gln Glu Lys Ile Tyr Tyr Val Gly 
    130                 135                 140                 


Tyr Ser Gln Gly Thr Thr Met Gly Phe Ile Ala Phe Ser Thr Met Pro 
145                 150                 155                 160 


Glu Leu Ala Gln Lys Ile Lys Met Tyr Phe Ala Leu Ala Pro Ile Ala 
                165                 170                 175     


Thr Val Lys His Ala Lys Ser Pro Gly Thr Lys Phe Leu Leu Leu Pro 
            180                 185                 190         


Asp Met Met Ile Lys Gly Leu Phe Gly Lys Lys Glu Phe Leu Tyr Gln 
        195                 200                 205             


Thr Arg Phe Leu Arg Gln Leu Val Ile Tyr Leu Cys Gly Gln Val Ile 
    210                 215                 220                 


Leu Asp Gln Ile Cys Ser Asn Ile Met Leu Leu Leu Gly Gly Phe Asn 
225                 230                 235                 240 


Thr Asn Asn Met Asn Met Ser Arg Ala Ser Val Tyr Ala Ala His Thr 
                245                 250                 255     


Leu Ala Gly Thr Ser Val Gln Asn Ile Leu His Trp Ser Gln Ala Val 
            260                 265                 270         


Asn Ser Gly Glu Leu Arg Ala Phe Asp Trp Gly Ser Glu Thr Lys Asn 
        275                 280                 285             


Leu Glu Lys Cys Asn Gln Pro Thr Pro Val Arg Tyr Arg Val Arg Asp 
    290                 295                 300                 


Met Thr Val Pro Thr Ala Met Trp Thr Gly Gly Gln Asp Trp Leu Ser 
305                 310                 315                 320 


Asn Pro Glu Asp Val Lys Met Leu Leu Ser Glu Val Thr Asn Leu Ile 
                325                 330                 335     


Tyr His Lys Asn Ile Pro Glu Trp Ala His Val Asp Phe Ile Trp Gly 
            340                 345                 350         


Leu Asp Ala Pro His Arg Met Tyr Asn Glu Ile Ile His Leu Met Gln 
        355                 360                 365             


Gln Glu Glu Thr Asn Leu Ser Gln Gly Arg Cys Glu Ala Val Leu 
    370                 375                 380             


<210>  7921
<211>  398
<212>  PRT
<213>  Homo Sapiens

<400>  7921

Met Met Trp Leu Leu Leu Thr Thr Thr Cys Leu Ile Cys Gly Thr Leu 
1               5                   10                  15      


Asn Ala Gly Gly Phe Leu Asp Leu Glu Asn Glu Val Asn Pro Glu Val 
            20                  25                  30          


Trp Met Asn Thr Ser Glu Ile Ile Ile Tyr Asn Gly Tyr Pro Ser Glu 
        35                  40                  45              


Glu Tyr Glu Val Thr Thr Glu Asp Gly Tyr Ile Leu Leu Val Asn Arg 
    50                  55                  60                  


Ile Pro Tyr Gly Arg Thr His Ala Arg Ser Thr Gly Pro Arg Pro Val 
65                  70                  75                  80  


Val Tyr Met Gln His Ala Leu Phe Ala Asp Asn Ala Tyr Trp Leu Glu 
                85                  90                  95      


Asn Tyr Ala Asn Gly Ser Leu Gly Phe Leu Leu Ala Asp Ala Gly Tyr 
            100                 105                 110         


Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Arg His 
        115                 120                 125             


Lys Thr Leu Ser Glu Thr Asp Glu Lys Phe Trp Ala Phe Ser Phe Asp 
    130                 135                 140                 


Glu Met Ala Lys Tyr Asp Leu Pro Gly Val Ile Asp Phe Ile Val Asn 
145                 150                 155                 160 


Lys Thr Gly Gln Glu Lys Leu Tyr Phe Ile Gly His Ser Leu Gly Thr 
                165                 170                 175     


Thr Ile Gly Phe Val Ala Phe Ser Thr Met Pro Glu Leu Ala Gln Arg 
            180                 185                 190         


Ile Lys Met Asn Phe Ala Leu Gly Pro Thr Ile Ser Phe Lys Tyr Pro 
        195                 200                 205             


Thr Gly Ile Phe Thr Arg Phe Phe Leu Leu Pro Asn Ser Ile Ile Lys 
    210                 215                 220                 


Ala Val Phe Gly Thr Lys Gly Phe Phe Leu Glu Asp Lys Lys Thr Lys 
225                 230                 235                 240 


Ile Ala Ser Thr Lys Ile Cys Asn Asn Lys Ile Leu Trp Leu Ile Cys 
                245                 250                 255     


Ser Glu Phe Met Ser Leu Trp Ala Gly Ser Asn Lys Lys Asn Met Asn 
            260                 265                 270         


Gln Ser Arg Met Asp Val Tyr Met Ser His Ala Pro Thr Gly Ser Ser 
        275                 280                 285             


Val His Asn Ile Leu His Ile Lys Gln Leu Tyr His Ser Asp Glu Phe 
    290                 295                 300                 


Arg Ala Tyr Asp Trp Gly Asn Asp Ala Asp Asn Met Lys His Tyr Asn 
305                 310                 315                 320 


Gln Ser His Pro Pro Ile Tyr Asp Leu Thr Ala Met Lys Val Pro Thr 
                325                 330                 335     


Ala Ile Trp Ala Gly Gly His Asp Val Leu Val Thr Pro Gln Asp Val 
            340                 345                 350         


Ala Arg Ile Leu Pro Gln Ile Lys Ser Leu His Tyr Phe Lys Leu Leu 
        355                 360                 365             


Pro Asp Trp Asn His Phe Asp Phe Val Trp Gly Leu Asp Ala Pro Gln 
    370                 375                 380                 


Arg Met Tyr Ser Glu Ile Ile Ala Leu Met Lys Ala Tyr Ser 
385                 390                 395             


<210>  7922
<211>  288
<212>  PRT
<213>  Homo Sapiens

<400>  7922

Met Ala Ala Glu Gly Trp Ile Trp Arg Trp Gly Trp Gly Arg Arg Cys 
1               5                   10                  15      


Leu Gly Arg Pro Gly Leu Leu Gly Pro Gly Pro Gly Pro Thr Thr Pro 
            20                  25                  30          


Leu Phe Leu Leu Leu Leu Leu Gly Ser Val Thr Ala Asp Ile Thr Asp 
        35                  40                  45              


Gly Asn Ser Glu His Leu Lys Arg Glu His Ser Leu Ile Lys Pro Tyr 
    50                  55                  60                  


Gln Gly Val Gly Ser Ser Ser Met Pro Leu Trp Asp Phe Gln Gly Ser 
65                  70                  75                  80  


Thr Met Leu Thr Ser Gln Tyr Val Arg Leu Thr Pro Asp Glu Arg Ser 
                85                  90                  95      


Lys Glu Gly Ser Ile Trp Asn His Gln Pro Cys Phe Leu Lys Asp Trp 
            100                 105                 110         


Glu Met His Val His Phe Lys Val His Gly Thr Gly Lys Lys Asn Leu 
        115                 120                 125             


His Gly Asp Gly Ile Ala Leu Trp Tyr Thr Arg Asp Arg Leu Val Pro 
    130                 135                 140                 


Asp Asn Phe His Gly Leu Ala Ile Phe Leu Asp Thr Tyr Pro Asn Asp 
145                 150                 155                 160 


Glu Thr Thr Glu Arg Val Phe Pro Tyr Ile Ser Val Met Val Asn Asn 
                165                 170                 175     


Gly Ser Leu Ser Tyr Asp His Ser Lys Asp Gly Arg Trp Thr Glu Leu 
            180                 185                 190         


Ala Gly Cys Thr Ala Asp Phe Arg Asn Arg Asp His Asp Thr Phe Leu 
        195                 200                 205             


Ala Val Arg Tyr Ser Arg Gly Arg Leu Thr Val Met Thr Asp Leu Glu 
    210                 215                 220                 


Asp Lys Asn Glu Trp Lys Asn Cys Ile Asp Ile Thr Gly Val Arg Leu 
225                 230                 235                 240 


Pro Thr Gly Tyr Tyr Phe Gly Ala Ser Ala Gly Thr Gly Asp Leu Ser 
                245                 250                 255     


Asp Asn His Asp Ile Ile Ser Met Lys Leu Phe Gln Leu Met Val Glu 
            260                 265                 270         


His Thr Pro Asp Glu Glu Ser Ile Asp Trp Thr Lys Ile Glu Pro Ser 
        275                 280                 285             


<210>  7923
<211>  203
<212>  PRT
<213>  Homo Sapiens

<400>  7923

Met Ala Ala Glu Gly Trp Ile Trp Arg Trp Gly Trp Gly Arg Arg Cys 
1               5                   10                  15      


Leu Gly Arg Pro Gly Leu Leu Gly Pro Gly Pro Gly Pro Thr Thr Pro 
            20                  25                  30          


Leu Phe Leu Leu Leu Leu Leu Gly Ser Val Thr Ala Asp Ile Thr Asp 
        35                  40                  45              


Gly Asn Ser Glu His Leu Lys Arg Glu His Ser Leu Ile Lys Pro Tyr 
    50                  55                  60                  


Gln Gly Val Gly Ser Ser Ser Met Pro Leu Trp Asp Phe Gln Gly Ser 
65                  70                  75                  80  


Thr Met Leu Thr Ser Gln Tyr Val Arg Leu Thr Pro Asp Glu Arg Ser 
                85                  90                  95      


Lys Glu Gly Ser Ile Trp Asn His Gln Pro Cys Phe Leu Lys Asp Trp 
            100                 105                 110         


Glu Met His Val His Phe Lys Val His Gly Thr Gly Lys Lys Asn Leu 
        115                 120                 125             


His Gly Asp Gly Ile Ala Leu Trp Tyr Thr Arg Asp Arg Leu Val Pro 
    130                 135                 140                 


Gly Pro Val Phe Gly Ser Lys Asp Asn Phe His Gly Leu Ala Ile Phe 
145                 150                 155                 160 


Leu Asp Thr Tyr Pro Asn Asp Glu Thr Thr Glu His Arg Leu Asp Gln 
                165                 170                 175     


Asp Arg Ala Gln Arg Gln Leu Pro Gln Val Ala Gln Arg Gln Arg Gly 
            180                 185                 190         


Arg Pro His Gly Glu Leu Pro Gln Arg Ala Pro 
        195                 200             


<210>  7924
<211>  356
<212>  PRT
<213>  Homo Sapiens

<400>  7924

Met Ala Ala Glu Gly Trp Ile Trp Arg Trp Gly Trp Gly Arg Arg Cys 
1               5                   10                  15      


Leu Gly Arg Pro Gly Leu Leu Gly Pro Gly Pro Gly Pro Thr Thr Pro 
            20                  25                  30          


Leu Phe Leu Leu Leu Leu Leu Gly Ser Val Thr Ala Asp Ile Thr Asp 
        35                  40                  45              


Gly Asn Ser Glu His Leu Lys Arg Glu His Ser Leu Ile Lys Pro Tyr 
    50                  55                  60                  


Gln Gly Val Gly Ser Ser Ser Met Pro Leu Trp Asp Phe Gln Gly Ser 
65                  70                  75                  80  


Thr Met Leu Thr Ser Gln Tyr Val Arg Leu Thr Pro Asp Glu Arg Ser 
                85                  90                  95      


Lys Glu Gly Ser Ile Trp Asn His Gln Pro Cys Phe Leu Lys Asp Trp 
            100                 105                 110         


Glu Met His Val His Phe Lys Val His Gly Thr Gly Lys Lys Asn Leu 
        115                 120                 125             


His Gly Asp Gly Ile Ala Leu Trp Tyr Thr Arg Asp Arg Leu Val Pro 
    130                 135                 140                 


Gly Pro Val Phe Gly Ser Lys Asp Asn Phe His Gly Leu Ala Ile Phe 
145                 150                 155                 160 


Leu Asp Thr Tyr Pro Asn Asp Glu Thr Thr Glu Arg Val Phe Pro Tyr 
                165                 170                 175     


Ile Ser Val Met Val Asn Asn Gly Ser Leu Ser Tyr Asp His Ser Lys 
            180                 185                 190         


Asp Gly Arg Trp Thr Glu Leu Ala Gly Cys Thr Ala Asp Phe Arg Asn 
        195                 200                 205             


Arg Asp His Asp Thr Phe Leu Ala Val Arg Tyr Ser Arg Gly Arg Leu 
    210                 215                 220                 


Thr Val Met Thr Asp Leu Glu Asp Lys Asn Glu Trp Lys Asn Cys Ile 
225                 230                 235                 240 


Asp Ile Thr Gly Val Arg Leu Pro Thr Gly Tyr Tyr Phe Gly Ala Ser 
                245                 250                 255     


Ala Gly Thr Gly Asp Leu Ser Asp Asn His Asp Ile Ile Ser Met Lys 
            260                 265                 270         


Leu Phe Gln Leu Met Val Glu His Thr Pro Asp Glu Glu Ser Ile Asp 
        275                 280                 285             


Trp Thr Lys Ile Glu Pro Ser Val Asn Phe Leu Lys Ser Pro Lys Asp 
    290                 295                 300                 


Asn Val Asp Asp Pro Thr Gly Asn Phe Arg Ser Gly Pro Leu Thr Gly 
305                 310                 315                 320 


Trp Arg Val Phe Leu Leu Leu Leu Cys Ala Leu Leu Gly Ile Val Val 
                325                 330                 335     


Cys Ala Val Val Gly Ala Val Val Phe Gln Lys Arg Gln Glu Arg Asn 
            340                 345                 350         


Lys Arg Phe Tyr 
        355     


<210>  7925
<211>  325
<212>  PRT
<213>  Homo Sapiens

<400>  7925

Met Ala Ala Glu Gly Trp Ile Trp Arg Trp Gly Trp Gly Arg Arg Cys 
1               5                   10                  15      


Leu Gly Arg Pro Gly Leu Leu Gly Pro Gly Pro Gly Pro Thr Thr Pro 
            20                  25                  30          


Leu Phe Leu Leu Leu Leu Leu Gly Ser Val Thr Ala Asp Ile Thr Asp 
        35                  40                  45              


Gly Asn Ser Glu His Leu Lys Arg Glu His Ser Leu Ile Lys Pro Tyr 
    50                  55                  60                  


Gln Gly Val Gly Ser Ser Ser Met Pro Leu Trp Asp Phe Gln Gly Ser 
65                  70                  75                  80  


Thr Met Leu Thr Ser Gln Tyr Val Arg Leu Thr Pro Asp Glu Arg Ser 
                85                  90                  95      


Lys Glu Gly Ser Ile Trp Asn His Gln Pro Cys Phe Leu Lys Asp Trp 
            100                 105                 110         


Glu Met His Val His Phe Lys Val His Gly Thr Gly Lys Lys Asn Leu 
        115                 120                 125             


His Gly Asp Gly Ile Ala Leu Trp Tyr Thr Arg Asp Arg Leu Val Pro 
    130                 135                 140                 


Gly Pro Val Phe Gly Ser Lys Asp Asn Phe His Gly Leu Ala Ile Phe 
145                 150                 155                 160 


Leu Asp Thr Tyr Pro Asn Asp Glu Thr Thr Glu Arg Val Phe Pro Tyr 
                165                 170                 175     


Ile Ser Val Met Val Asn Asn Gly Ser Leu Ser Tyr Asp His Ser Lys 
            180                 185                 190         


Asp Gly Arg Trp Thr Glu Leu Ala Gly Cys Thr Ala Asp Phe Arg Asn 
        195                 200                 205             


Arg Asp His Asp Thr Phe Leu Ala Val Arg Tyr Ser Arg Gly Arg Leu 
    210                 215                 220                 


Thr Val Met Thr Asp Leu Glu Asp Lys Asn Glu Trp Lys Asn Cys Ile 
225                 230                 235                 240 


Asp Ile Thr Gly Val Arg Leu Pro Thr Gly Tyr Tyr Phe Gly Ala Ser 
                245                 250                 255     


Ala Gly Thr Gly Asp Leu Ser Asp Asn His Asp Ile Ile Ser Met Lys 
            260                 265                 270         


Leu Phe Gln Leu Met Val Glu His Thr Pro Asp Glu Glu Ser Ile Asp 
        275                 280                 285             


Trp Thr Lys Ile Glu Pro Ser Val Asn Phe Leu Lys Ser Pro Lys Ala 
    290                 295                 300                 


Pro Pro Phe Leu Leu Pro Gln Thr Thr Trp Thr Thr Pro Arg Gly Thr 
305                 310                 315                 320 


Ser Ala Ala Gly Pro 
                325 


<210>  7926
<211>  192
<212>  PRT
<213>  Homo Sapiens

<400>  7926

Met Pro Leu Trp Asp Phe Gln Gly Ser Thr Met Leu Thr Ser Gln Tyr 
1               5                   10                  15      


Val Arg Leu Thr Pro Asp Glu Arg Ser Lys Glu Gly Ser Ile Trp Asn 
            20                  25                  30          


His Gln Pro Cys Phe Leu Lys Asp Trp Glu Met His Val His Phe Lys 
        35                  40                  45              


Val His Gly Thr Gly Lys Lys Asn Leu His Gly Asp Gly Ile Ala Leu 
    50                  55                  60                  


Trp Tyr Thr Arg Asp Arg Leu Val Pro Gly Pro Val Phe Gly Ser Lys 
65                  70                  75                  80  


Asp Asn Phe His Gly Leu Ala Ile Phe Leu Asp Thr Tyr Pro Asn Asp 
                85                  90                  95      


Glu Thr Thr Glu Arg Val Phe Pro Tyr Ile Ser Val Met Val Asn Asn 
            100                 105                 110         


Gly Ser Leu Ser Tyr Asp His Ser Lys Asp Gly Arg Trp Thr Glu Leu 
        115                 120                 125             


Ala Gly Cys Thr Ala Asp Phe Arg Asn Arg Asp His Asp Thr Phe Leu 
    130                 135                 140                 


Ala Val Arg Tyr Ser Arg Gly Arg Leu Thr Val Met Thr Asp Leu Glu 
145                 150                 155                 160 


Asp Lys Asn Glu Trp Lys Asn Cys Ile Asp Ile Thr Gly Val Arg Leu 
                165                 170                 175     


Pro Thr Gly Tyr Tyr Phe Gly Ala Ser Ala Gly Thr Gly Asp Leu Ser 
            180                 185                 190         


<210>  7927
<211>  144
<212>  PRT
<213>  Homo Sapiens

<400>  7927

Met Ala Ile Gly Asp His Ile Leu Gln Gln Asn Val Asn Gly Gln Thr 
1               5                   10                  15      


Ile Ser Leu Tyr Arg Phe Leu Pro Asn Ile Val Met Gln Ala Asn Ser 
            20                  25                  30          


Thr Val Thr Val Trp Ala Ala Ala Ser Glu Ala Lys His Gln Pro Pro 
        35                  40                  45              


Ser Asp Phe Leu Trp Lys Glu Gln Asp Lys Phe Arg Ala Ser Pro Asp 
    50                  55                  60                  


Cys Ile Thr Ile Leu Cys Lys Pro Asn Gly Gln Ala Ile Ala Trp Tyr 
65                  70                  75                  80  


Thr Pro Ile His Trp Lys Gln Ala Trp Glu Lys Leu Asp Ala Asp Val 
                85                  90                  95      


Glu Phe Asn Arg Cys Ser Val Val Ser Pro Thr Phe Arg Lys Arg Val 
            100                 105                 110         


Phe Gln Trp Thr Ala Ser Thr Ala Thr Ile Thr Lys Glu Lys Gln Asp 
        115                 120                 125             


Gln Pro Lys Lys Asp Ile Ser Asn Tyr Gln Val Glu Gln Ala Gln Val 
    130                 135                 140                 


<210>  7928
<211>  291
<212>  PRT
<213>  Homo Sapiens

<400>  7928

Met Ile Gly Asp Gly Glu Asp Tyr Phe Leu Ser Leu Phe Gly Asp Ser 
1               5                   10                  15      


Lys Lys Leu Thr Ala His Ser Asn Tyr Thr Gln Lys Thr Leu Lys Tyr 
            20                  25                  30          


Phe Ser Met Ile Leu Glu Glu Val Gly Gln Phe Thr Ser Ser Ser Leu 
        35                  40                  45              


Gly Asp Val Glu Ile Ala Glu Val Asn Val Lys Gly Leu Phe Val Lys 
    50                  55                  60                  


Leu Ile Asn Ser Ser Leu Asp Lys Glu Met Ala Ile Gly Asp His Ile 
65                  70                  75                  80  


Leu Gln Gln Asn Val Asn Gly Gln Thr Ile Ser Leu Tyr Arg Phe Leu 
                85                  90                  95      


Pro Asn Ile Val Met Gln Ala Asn Ser Thr Val Thr Val Trp Ala Ala 
            100                 105                 110         


Ala Ser Glu Ala Lys His Gln Pro Pro Ser Asp Phe Leu Trp Lys Glu 
        115                 120                 125             


Gln Asp Lys Phe Arg Ala Ser Pro Asp Cys Ile Thr Ile Leu Cys Lys 
    130                 135                 140                 


Pro Asn Gly Gln Ala Ile Ala Trp Tyr Thr Pro Ile His Trp Lys Gln 
145                 150                 155                 160 


Ala Trp Glu Lys Leu Asp Ala Asp Val Glu Phe Asn Arg Cys Ser Val 
                165                 170                 175     


Val Ser Pro Thr Phe Arg Lys Arg Val Phe Gln Trp Thr Ala Ser Thr 
            180                 185                 190         


Ala Thr Ile Thr Lys Glu Lys Gln Asp Gln Pro Lys Lys Asp Ile Ser 
        195                 200                 205             


Asn Tyr Gln Val Glu Gln Ala Gln Val Leu Leu Lys Arg Glu Lys Glu 
    210                 215                 220                 


Ile Pro Pro Thr Val Phe Pro Asn Arg Ser Pro Trp Cys Gln Asn Pro 
225                 230                 235                 240 


Tyr Val Ser Ala His Pro Tyr Cys Pro Leu Ile Glu Pro His Asn Thr 
                245                 250                 255     


Ser Thr Ala Gly Gly Arg Leu Asp Arg Gln Pro Arg Thr Arg Ser Thr 
            260                 265                 270         


Arg Pro Asn Arg Ala Ser Gly Ser Lys Lys Lys Lys Thr Ser Glu Ser 
        275                 280                 285             


Gln Lys Gln 
    290     


<210>  7929
<211>  369
<212>  PRT
<213>  Homo Sapiens

<400>  7929

Met Lys Asp Thr Gln Asp Ile Gln Glu Ala Ser Lys Ala Met Gln Asn 
1               5                   10                  15      


Lys Val His Glu Gln Glu Asp Lys Asn Glu Lys Gln Lys Gln Arg Glu 
            20                  25                  30          


Asp Lys Leu Gly Val Tyr Ser Leu Val His Phe Ser Pro Lys Met Leu 
        35                  40                  45              


Gly Ser Val Ala Thr Thr Leu Pro Leu Ser Ser Ser Asn Ser Ser Gly 
    50                  55                  60                  


Met Pro Leu Gly Tyr Tyr Leu Ser Ser Pro Gln Ile Ser Arg Val Thr 
65                  70                  75                  80  


Ile Ser Thr Thr Gly Gln Leu Thr Ser Lys Ala Thr Val Gly Ser Cys 
                85                  90                  95      


Ser Arg Val Glu Asn Ser Leu Asp Ala Ser Pro Phe Ser Val Pro Lys 
            100                 105                 110         


Lys Gln Asp Glu Ser Pro Met Ile Gly Asp Gly Glu Asp Tyr Phe Leu 
        115                 120                 125             


Ser Leu Phe Gly Asp Ser Lys Lys Leu Thr Ala His Ser Asn Tyr Thr 
    130                 135                 140                 


Gln Lys Thr Leu Lys Tyr Phe Ser Met Ile Leu Glu Glu Val Gly Gln 
145                 150                 155                 160 


Phe Thr Ser Ser Ser Leu Gly Asp Val Glu Ile Ala Glu Val Asn Val 
                165                 170                 175     


Lys Gly Leu Phe Val Lys Leu Ile Asn Ser Ser Leu Asp Lys Glu Met 
            180                 185                 190         


Ala Ile Gly Asp His Ile Leu Gln Gln Asn Val Asn Gly Gln Thr Ile 
        195                 200                 205             


Ser Leu Tyr Arg Phe Leu Pro Asn Ile Val Met Gln Ala Asn Ser Thr 
    210                 215                 220                 


Val Thr Ala Ile Ala Trp Tyr Thr Pro Ile His Trp Lys Gln Ala Trp 
225                 230                 235                 240 


Glu Lys Leu Asp Ala Asp Val Glu Phe Asn Arg Cys Ser Val Val Ser 
                245                 250                 255     


Pro Thr Phe Arg Lys Arg Val Phe Gln Trp Thr Ala Ser Thr Ala Thr 
            260                 265                 270         


Ile Thr Lys Glu Lys Gln Asp Gln Pro Lys Lys Asp Ile Ser Asn Tyr 
        275                 280                 285             


Gln Val Glu Gln Ala Gln Val Leu Leu Lys Arg Glu Lys Glu Ile Pro 
    290                 295                 300                 


Pro Thr Val Phe Pro Asn Arg Ser Pro Trp Cys Gln Asn Pro Tyr Val 
305                 310                 315                 320 


Ser Ala His Pro Tyr Cys Pro Leu Ile Glu Pro His Asn Thr Ser Thr 
                325                 330                 335     


Ala Gly Gly Arg Leu Asp Arg Gln Pro Arg Thr Arg Ser Thr Arg Pro 
            340                 345                 350         


Asn Arg Ala Ser Gly Ser Lys Lys Lys Lys Thr Ser Glu Ser Gln Lys 
        355                 360                 365             


Gln 
    


<210>  7930
<211>  409
<212>  PRT
<213>  Homo Sapiens

<400>  7930

Met Lys Asp Thr Gln Asp Ile Gln Glu Ala Ser Lys Ala Met Gln Asn 
1               5                   10                  15      


Lys Val His Glu Gln Glu Asp Lys Asn Glu Lys Gln Lys Gln Arg Glu 
            20                  25                  30          


Asp Lys Leu Gly Val Tyr Ser Leu Val His Phe Ser Pro Lys Met Leu 
        35                  40                  45              


Gly Ser Val Ala Thr Thr Leu Pro Leu Ser Ser Ser Asn Ser Ser Gly 
    50                  55                  60                  


Met Pro Leu Gly Tyr Tyr Leu Ser Ser Pro Gln Ile Ser Arg Val Thr 
65                  70                  75                  80  


Ile Ser Thr Thr Gly Gln Leu Thr Ser Lys Ala Thr Val Gly Ser Cys 
                85                  90                  95      


Ser Arg Val Glu Asn Ser Leu Asp Ala Ser Pro Phe Ser Val Pro Lys 
            100                 105                 110         


Lys Gln Asp Glu Ser Pro Met Ile Gly Asp Gly Glu Asp Tyr Phe Leu 
        115                 120                 125             


Ser Leu Phe Gly Asp Ser Lys Lys Leu Thr Ala His Ser Asn Tyr Thr 
    130                 135                 140                 


Gln Lys Thr Leu Lys Tyr Phe Ser Met Ile Leu Glu Glu Val Gly Gln 
145                 150                 155                 160 


Phe Thr Ser Ser Ser Leu Gly Asp Val Glu Ile Ala Glu Val Asn Val 
                165                 170                 175     


Lys Gly Leu Phe Val Lys Leu Ile Asn Ser Ser Leu Asp Lys Glu Met 
            180                 185                 190         


Ala Ile Gly Asp His Ile Leu Gln Gln Asn Val Asn Gly Gln Thr Ile 
        195                 200                 205             


Ser Leu Tyr Arg Phe Leu Pro Asn Ile Val Met Gln Ala Asn Ser Thr 
    210                 215                 220                 


Val Thr Val Trp Ala Ala Ala Ser Glu Ala Lys His Gln Pro Pro Ser 
225                 230                 235                 240 


Asp Phe Leu Trp Lys Glu Gln Asp Lys Phe Arg Ala Ser Pro Asp Cys 
                245                 250                 255     


Ile Thr Ile Leu Cys Lys Pro Asn Gly Gln Ala Ile Ala Trp Tyr Thr 
            260                 265                 270         


Pro Ile His Trp Lys Gln Ala Trp Glu Lys Leu Asp Ala Asp Val Glu 
        275                 280                 285             


Phe Asn Arg Cys Ser Val Val Ser Pro Thr Phe Arg Lys Arg Val Phe 
    290                 295                 300                 


Gln Trp Thr Ala Ser Thr Ala Thr Ile Thr Lys Glu Lys Gln Asp Gln 
305                 310                 315                 320 


Pro Lys Lys Asp Ile Ser Asn Tyr Gln Val Glu Gln Ala Gln Val Leu 
                325                 330                 335     


Leu Lys Arg Glu Lys Glu Ile Pro Pro Thr Val Phe Pro Asn Arg Ser 
            340                 345                 350         


Pro Trp Cys Gln Asn Pro Tyr Val Ser Ala His Pro Tyr Cys Pro Leu 
        355                 360                 365             


Ile Glu Pro His Asn Thr Ser Thr Ala Gly Gly Arg Leu Asp Arg Gln 
    370                 375                 380                 


Pro Arg Thr Arg Ser Thr Arg Pro Asn Arg Ala Ser Gly Ser Lys Lys 
385                 390                 395                 400 


Lys Lys Thr Ser Glu Ser Gln Lys Gln 
                405                 


<210>  7931
<211>  388
<212>  PRT
<213>  Homo Sapiens

<400>  7931

Met Leu Glu Gly Ser Trp Ile Asn Arg Arg Glu Asp Lys Leu Gly Val 
1               5                   10                  15      


Tyr Ser Leu Val His Phe Ser Pro Lys Met Leu Gly Ser Val Ala Thr 
            20                  25                  30          


Thr Leu Pro Leu Ser Ser Ser Asn Ser Ser Gly Met Pro Leu Gly Tyr 
        35                  40                  45              


Tyr Leu Ser Ser Pro Gln Ile Ser Arg Val Thr Ile Ser Thr Thr Gly 
    50                  55                  60                  


Gln Leu Thr Ser Lys Ala Thr Val Gly Ser Cys Ser Arg Val Glu Asn 
65                  70                  75                  80  


Ser Leu Asp Ala Ser Pro Phe Ser Val Pro Lys Lys Gln Asp Glu Ser 
                85                  90                  95      


Pro Met Ile Gly Asp Gly Glu Asp Tyr Phe Leu Ser Leu Phe Gly Asp 
            100                 105                 110         


Ser Lys Lys Leu Thr Ala His Ser Asn Tyr Thr Gln Lys Thr Leu Lys 
        115                 120                 125             


Tyr Phe Ser Met Ile Leu Glu Glu Val Gly Gln Phe Thr Ser Ser Ser 
    130                 135                 140                 


Leu Gly Asp Val Glu Ile Ala Glu Val Asn Val Lys Gly Leu Phe Val 
145                 150                 155                 160 


Lys Leu Ile Asn Ser Ser Leu Asp Lys Glu Met Ala Ile Gly Asp His 
                165                 170                 175     


Ile Leu Gln Gln Asn Val Asn Gly Gln Thr Ile Ser Leu Tyr Arg Phe 
            180                 185                 190         


Leu Pro Asn Ile Val Met Gln Ala Asn Ser Thr Val Thr Val Trp Ala 
        195                 200                 205             


Ala Ala Ser Glu Ala Lys His Gln Pro Pro Ser Asp Phe Leu Trp Lys 
    210                 215                 220                 


Glu Gln Asp Lys Phe Arg Ala Ser Pro Asp Cys Ile Thr Ile Leu Cys 
225                 230                 235                 240 


Lys Pro Asn Gly Gln Ala Ile Ala Trp Tyr Thr Pro Ile His Trp Lys 
                245                 250                 255     


Gln Ala Trp Glu Lys Leu Asp Ala Asp Val Glu Phe Asn Arg Cys Ser 
            260                 265                 270         


Val Val Ser Pro Thr Phe Arg Lys Arg Val Phe Gln Trp Thr Ala Ser 
        275                 280                 285             


Thr Ala Thr Ile Thr Lys Glu Lys Gln Asp Gln Pro Lys Lys Asp Ile 
    290                 295                 300                 


Ser Asn Tyr Gln Val Glu Gln Ala Gln Val Leu Leu Lys Arg Glu Lys 
305                 310                 315                 320 


Glu Ile Pro Pro Thr Val Phe Pro Asn Arg Ser Pro Trp Cys Gln Asn 
                325                 330                 335     


Pro Tyr Val Ser Ala His Pro Tyr Cys Pro Leu Ile Glu Pro His Asn 
            340                 345                 350         


Thr Ser Thr Ala Gly Gly Arg Leu Asp Arg Gln Pro Arg Thr Arg Ser 
        355                 360                 365             


Thr Arg Pro Asn Arg Ala Ser Gly Ser Lys Lys Lys Lys Thr Ser Glu 
    370                 375                 380                 


Ser Gln Lys Gln 
385             


<210>  7932
<211>  72
<212>  PRT
<213>  Homo Sapiens

<400>  7932

Met Leu Gly Ser Val Ala Thr Thr Leu Pro Leu Ser Ser Ser Asn Ser 
1               5                   10                  15      


Ser Gly Met Pro Leu Gly Tyr Tyr Leu Ser Ser Pro Gln Ile Ser Arg 
            20                  25                  30          


Val Thr Ile Ser Thr Thr Gly Gln Leu Thr Ser Lys Ala Thr Val Gly 
        35                  40                  45              


Ser Cys Ser Arg Val Glu Asn Ser Leu Asp Ala Ser Pro Phe Ser Val 
    50                  55                  60                  


Pro Lys Lys Gln Asp Glu Ser Pro 
65                  70          


<210>  7933
<211>  166
<212>  PRT
<213>  Homo Sapiens

<400>  7933

Met Leu Gly Ser Val Ala Thr Thr Leu Pro Leu Ser Ser Ser Asn Ser 
1               5                   10                  15      


Ser Gly Met Pro Leu Gly Tyr Tyr Leu Ser Ser Pro Gln Ile Ser Arg 
            20                  25                  30          


Val Thr Ile Ser Thr Thr Gly Gln Leu Thr Ser Lys Ala Thr Val Gly 
        35                  40                  45              


Ser Cys Ser Arg Val Glu Asn Ser Leu Asp Ala Ser Pro Phe Ser Val 
    50                  55                  60                  


Pro Lys Lys Gln Asp Glu Ser Pro Met Ile Gly Asp Gly Glu Asp Tyr 
65                  70                  75                  80  


Phe Leu Ser Leu Phe Gly Asp Ser Lys Lys Leu Thr Ala His Ser Asn 
                85                  90                  95      


Tyr Thr Gln Lys Thr Leu Lys Tyr Phe Ser Met Ile Leu Glu Glu Val 
            100                 105                 110         


Gly Gln Phe Thr Ser Ser Ser Leu Gly Asp Val Glu Ile Ala Glu Val 
        115                 120                 125             


Asn Val Lys Gly Leu Phe Val Lys Leu Ile Asn Ser Ser Leu Asp Lys 
    130                 135                 140                 


Glu Met Ala Ile Gly Asp His Ile Leu Gln Gln Asn Val Asn Gly Gln 
145                 150                 155                 160 


Thr Ile Ser Leu Tyr Arg 
                165     


<210>  7934
<211>  170
<212>  PRT
<213>  Homo Sapiens

<400>  7934

Met Leu Gly Ser Val Ala Thr Thr Leu Pro Leu Ser Ser Ser Asn Ser 
1               5                   10                  15      


Ser Gly Met Pro Leu Gly Tyr Tyr Leu Ser Ser Pro Gln Ile Ser Arg 
            20                  25                  30          


Val Thr Ile Ser Thr Thr Gly Gln Leu Thr Ser Lys Ala Thr Val Gly 
        35                  40                  45              


Ser Cys Ser Arg Val Glu Asn Ser Leu Asp Ala Ser Pro Phe Ser Val 
    50                  55                  60                  


Pro Lys Lys Gln Asp Glu Ser Pro Met Ile Gly Asp Gly Glu Asp Tyr 
65                  70                  75                  80  


Phe Leu Ser Leu Phe Gly Asp Ser Lys Lys Leu Thr Ala His Ser Asn 
                85                  90                  95      


Tyr Thr Gln Lys Thr Leu Lys Tyr Phe Ser Met Ile Leu Glu Glu Val 
            100                 105                 110         


Gly Gln Phe Thr Ser Ser Ser Leu Gly Asp Val Glu Ile Ala Glu Val 
        115                 120                 125             


Asn Val Lys Gly Leu Phe Val Lys Leu Ile Asn Ser Ser Leu Asp Lys 
    130                 135                 140                 


Glu Met Ala Ile Gly Asp His Ile Leu Gln Gln Asn Val Asn Gly Gln 
145                 150                 155                 160 


Thr Ile Ser Leu Tyr Arg Phe Leu Pro Asn 
                165                 170 


<210>  7935
<211>  325
<212>  PRT
<213>  Homo Sapiens

<400>  7935

Met Gln Gln Pro Val Arg Ala Gly Asp Ile Gly Val Ser Arg Val Gln 
1               5                   10                  15      


Thr His His Asn Ala Ser Pro Phe Ser Val Pro Lys Lys Gln Asp Glu 
            20                  25                  30          


Ser Pro Met Ile Gly Asp Gly Glu Asp Tyr Phe Leu Ser Leu Phe Gly 
        35                  40                  45              


Asp Ser Lys Lys Leu Thr Ala His Ser Asn Tyr Thr Gln Lys Thr Leu 
    50                  55                  60                  


Lys Tyr Phe Ser Met Ile Leu Glu Glu Val Gly Gln Phe Thr Ser Ser 
65                  70                  75                  80  


Ser Leu Gly Asp Val Glu Ile Ala Glu Val Asn Val Lys Gly Leu Phe 
                85                  90                  95      


Val Lys Leu Ile Asn Ser Ser Leu Asp Lys Glu Met Ala Ile Gly Asp 
            100                 105                 110         


His Ile Leu Gln Gln Asn Val Asn Gly Gln Thr Ile Ser Leu Tyr Arg 
        115                 120                 125             


Phe Leu Pro Asn Ile Val Met Gln Ala Asn Ser Thr Val Thr Val Trp 
    130                 135                 140                 


Ala Ala Ala Ser Glu Ala Lys His Gln Pro Pro Ser Asp Phe Leu Trp 
145                 150                 155                 160 


Lys Glu Gln Asp Lys Phe Arg Ala Ser Pro Asp Cys Ile Thr Ile Leu 
                165                 170                 175     


Cys Lys Pro Asn Gly Gln Ala Ile Ala Trp Tyr Thr Pro Ile His Trp 
            180                 185                 190         


Lys Gln Ala Trp Glu Lys Leu Asp Ala Asp Val Glu Phe Asn Arg Cys 
        195                 200                 205             


Ser Val Val Ser Pro Thr Phe Arg Lys Arg Val Phe Gln Trp Thr Ala 
    210                 215                 220                 


Ser Thr Ala Thr Ile Thr Lys Glu Lys Gln Asp Gln Pro Lys Lys Asp 
225                 230                 235                 240 


Ile Ser Asn Tyr Gln Val Glu Gln Ala Gln Val Leu Leu Lys Arg Glu 
                245                 250                 255     


Lys Glu Ile Pro Pro Thr Val Phe Pro Asn Arg Ser Pro Trp Cys Gln 
            260                 265                 270         


Asn Pro Tyr Val Ser Ala His Pro Tyr Cys Pro Leu Ile Glu Pro His 
        275                 280                 285             


Asn Thr Ser Thr Ala Gly Gly Arg Leu Asp Arg Gln Pro Arg Thr Arg 
    290                 295                 300                 


Ser Thr Arg Pro Asn Arg Ala Ser Gly Ser Lys Lys Lys Lys Thr Ser 
305                 310                 315                 320 


Glu Ser Gln Lys Gln 
                325 


<210>  7936
<211>  105
<212>  PRT
<213>  Homo Sapiens

<400>  7936

Gln Trp Thr Ala Ser Thr Ala Thr Ile Thr Lys Glu Lys Gln Asp Gln 
1               5                   10                  15      


Pro Lys Lys Asp Ile Ser Asn Tyr Gln Val Glu Gln Ala Gln Val Leu 
            20                  25                  30          


Leu Lys Arg Glu Lys Glu Ile Pro Pro Thr Val Phe Pro Asn Arg Ser 
        35                  40                  45              


Pro Trp Cys Gln Asn Pro Tyr Val Ser Ala His Pro Tyr Cys Pro Leu 
    50                  55                  60                  


Ile Glu Pro His Asn Thr Ser Thr Ala Gly Gly Arg Leu Asp Arg Gln 
65                  70                  75                  80  


Pro Arg Thr Arg Ser Thr Arg Pro Asn Arg Ala Ser Gly Ser Lys Lys 
                85                  90                  95      


Lys Lys Thr Ser Glu Ser Gln Lys Gln 
            100                 105 


<210>  7937
<211>  163
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7937

Xaa Asp Lys Phe Arg Ala Ser Pro Asp Cys Ile Thr Ile Leu Cys Lys 
1               5                   10                  15      


Pro Asn Gly Gln Ala Ile Ala Trp Tyr Thr Pro Ile His Trp Lys Gln 
            20                  25                  30          


Ala Trp Glu Lys Leu Asp Ala Asp Val Glu Phe Asn Arg Cys Ser Val 
        35                  40                  45              


Val Ser Pro Thr Phe Arg Lys Arg Val Phe Gln Trp Thr Ala Ser Thr 
    50                  55                  60                  


Ala Thr Ile Thr Lys Glu Lys Gln Asp Gln Pro Lys Lys Asp Ile Ser 
65                  70                  75                  80  


Asn Tyr Gln Val Glu Gln Ala Gln Val Leu Leu Lys Arg Glu Lys Glu 
                85                  90                  95      


Ile Pro Pro Thr Val Phe Pro Asn Arg Ser Pro Trp Cys Gln Asn Pro 
            100                 105                 110         


Tyr Val Ser Ala His Pro Tyr Cys Pro Leu Ile Glu Pro His Asn Thr 
        115                 120                 125             


Ser Thr Ala Gly Gly Arg Leu Asp Arg Gln Pro Arg Thr Arg Ser Thr 
    130                 135                 140                 


Arg Pro Asn Arg Ala Ser Gly Ser Lys Lys Lys Lys Thr Ser Glu Ser 
145                 150                 155                 160 


Gln Lys Gln 
            


<210>  7938
<211>  632
<212>  PRT
<213>  Homo Sapiens

<400>  7938

Met Lys Ala Leu Leu Leu Leu Val Leu Pro Trp Leu Ser Pro Ala Asn 
1               5                   10                  15      


Tyr Ile Asp Asn Val Gly Asn Leu His Phe Leu Tyr Ser Glu Leu Cys 
            20                  25                  30          


Lys Gly Ala Ser His Tyr Gly Leu Thr Lys Asp Arg Lys Arg Arg Ser 
        35                  40                  45              


Gln Asp Gly Cys Pro Asp Gly Cys Ala Ser Leu Thr Ala Thr Ala Pro 
    50                  55                  60                  


Ser Pro Glu Val Ser Ala Ala Ala Thr Ile Ser Leu Met Thr Asp Glu 
65                  70                  75                  80  


Pro Gly Leu Asp Asn Pro Ala Tyr Val Ser Ser Ala Glu Asp Gly Gln 
                85                  90                  95      


Pro Ala Ile Ser Pro Val Asp Ser Gly Arg Ser Asn Arg Thr Arg Ala 
            100                 105                 110         


Arg Pro Phe Glu Arg Ser Thr Ile Arg Ser Arg Ser Phe Lys Lys Ile 
        115                 120                 125             


Asn Arg Ala Leu Ser Val Leu Arg Arg Thr Lys Ser Gly Ser Ala Val 
    130                 135                 140                 


Ala Asn His Ala Asp Gln Gly Arg Glu Asn Ser Glu Asn Thr Thr Ala 
145                 150                 155                 160 


Pro Glu Val Phe Pro Arg Leu Tyr His Leu Ile Pro Asp Gly Glu Ile 
                165                 170                 175     


Thr Ser Ile Lys Ile Asn Arg Val Asp Pro Ser Glu Ser Leu Ser Ile 
            180                 185                 190         


Arg Leu Val Gly Gly Ser Glu Thr Pro Leu Val His Ile Ile Ile Gln 
        195                 200                 205             


His Ile Tyr Arg Asp Gly Val Ile Ala Arg Asp Gly Arg Leu Leu Pro 
    210                 215                 220                 


Gly Asp Ile Ile Leu Lys Val Asn Gly Met Asp Ile Ser Asn Val Pro 
225                 230                 235                 240 


His Asn Tyr Ala Val Arg Leu Leu Arg Gln Pro Cys Gln Val Leu Trp 
                245                 250                 255     


Leu Thr Val Met Arg Glu Gln Lys Phe Arg Ser Arg Asn Asn Gly Gln 
            260                 265                 270         


Ala Pro Asp Ala Tyr Arg Pro Arg Asp Asp Ser Phe His Val Ile Leu 
        275                 280                 285             


Asn Lys Ser Ser Pro Glu Glu Gln Leu Gly Ile Lys Leu Val Arg Lys 
    290                 295                 300                 


Val Asp Glu Pro Gly Val Phe Ile Phe Asn Val Leu Asp Gly Gly Val 
305                 310                 315                 320 


Ala Tyr Arg His Gly Gln Leu Glu Glu Asn Asp Arg Val Leu Ala Ile 
                325                 330                 335     


Asn Gly His Asp Leu Arg Tyr Gly Ser Pro Glu Ser Ala Ala His Leu 
            340                 345                 350         


Ile Gln Ala Ser Glu Arg Arg Val His Leu Val Val Ser Arg Gln Val 
        355                 360                 365             


Arg Gln Arg Ser Pro Asp Ile Phe Gln Glu Ala Gly Trp Asn Ser Asn 
    370                 375                 380                 


Gly Ser Trp Ser Pro Gly Pro Gly Glu Arg Ser Asn Thr Pro Lys Pro 
385                 390                 395                 400 


Leu His Pro Thr Ile Thr Cys His Glu Lys Val Val Asn Ile Gln Lys 
                405                 410                 415     


Asp Pro Gly Glu Ser Leu Gly Met Thr Val Ala Gly Gly Ala Ser His 
            420                 425                 430         


Arg Glu Trp Asp Leu Pro Ile Tyr Val Ile Ser Val Glu Pro Gly Gly 
        435                 440                 445             


Val Ile Ser Arg Asp Gly Arg Ile Lys Thr Gly Asp Ile Leu Leu Asn 
    450                 455                 460                 


Val Asp Gly Val Glu Leu Thr Glu Val Ser Arg Ser Glu Ala Val Ala 
465                 470                 475                 480 


Leu Leu Lys Arg Thr Ser Ser Ser Ile Val Leu Lys Ala Leu Glu Val 
                485                 490                 495     


Lys Glu Tyr Glu Pro Gln Glu Asp Cys Ser Ser Pro Ala Ala Leu Asp 
            500                 505                 510         


Ser Asn His Asn Met Ala Pro Pro Ser Asp Trp Ser Pro Ser Trp Val 
        515                 520                 525             


Met Trp Leu Glu Leu Pro Arg Cys Leu Tyr Asn Cys Lys Asp Ile Val 
    530                 535                 540                 


Leu Arg Arg Asn Thr Ala Gly Ser Leu Gly Phe Cys Ile Val Gly Gly 
545                 550                 555                 560 


Tyr Glu Glu Tyr Asn Gly Asn Lys Pro Phe Phe Ile Lys Ser Ile Val 
                565                 570                 575     


Glu Gly Thr Pro Ala Tyr Asn Asp Gly Arg Ile Arg Cys Gly Asp Ile 
            580                 585                 590         


Leu Leu Ala Val Asn Gly Arg Ser Thr Ser Gly Met Ile His Ala Cys 
        595                 600                 605             


Leu Ala Arg Leu Leu Lys Glu Leu Lys Gly Arg Ile Thr Leu Thr Ile 
    610                 615                 620                 


Val Ser Trp Pro Gly Thr Phe Leu 
625                 630         


<210>  7939
<211>  6
<212>  PRT
<213>  Homo Sapiens

<400>  7939

Met Asn Gln Pro Glu Ser 
1               5       


<210>  7940
<211>  16
<212>  PRT
<213>  Homo Sapiens

<400>  7940

Met Asn Gln Pro Glu Ser Ala Asn Asp Pro Glu Pro Leu Cys Ala Val 
1               5                   10                  15      


<210>  7941
<211>  90
<212>  PRT
<213>  Homo Sapiens

<400>  7941

Met Asn Gln Pro Glu Ser Ala Asn Asp Pro Glu Pro Leu Cys Ala Val 
1               5                   10                  15      


Cys Gly Gln Ala His Ser Leu Glu Glu Asn His Phe Tyr Ser Tyr Pro 
            20                  25                  30          


Glu Glu Val Asp Asp Asp Leu Ile Cys His Ile Cys Leu Gln Ala Leu 
        35                  40                  45              


Leu Asp Pro Leu Asp Thr Pro Cys Gly His Thr Tyr Cys Thr Leu Cys 
    50                  55                  60                  


Leu Thr Asn Phe Leu Val Glu Lys Asp Phe Cys Pro Met Asp Arg Lys 
65                  70                  75                  80  


Pro Leu Val Leu Gln His Cys Lys Lys Ser 
                85                  90  


<210>  7942
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  7942

Met Asn Gln Pro Glu Ser Ala Asn Asp Pro Glu Pro Leu Cys Ala Val 
1               5                   10                  15      


Cys Gly Gln Ala His Ser Leu Glu Glu Asn His Phe Tyr Ser Tyr Pro 
            20                  25                  30          


Glu Glu Val Asp Asp Asp Leu Ile Cys His Ile Cys Leu Gln Ala Leu 
        35                  40                  45              


Leu Asp Pro Leu Asp Thr Pro Cys Gly His Thr Tyr Cys Thr Leu Cys 
    50                  55                  60                  


Leu Thr Asn Phe Leu Val Glu Lys Asp Phe Cys Pro Met Asp Arg Lys 
65                  70                  75                  80  


Pro Leu Val Leu Gln His Cys Lys Lys Ser Ser Ile Leu Val Asn Lys 
                85                  90                  95      


Leu Leu Asn 
            


<210>  7943
<211>  126
<212>  PRT
<213>  Homo Sapiens

<400>  7943

Met Asn Gln Pro Glu Ser Ala Asn Asp Pro Glu Pro Leu Cys Ala Val 
1               5                   10                  15      


Cys Gly Gln Ala His Ser Leu Glu Glu Asn His Phe Tyr Ser Tyr Pro 
            20                  25                  30          


Glu Glu Val Asp Asp Asp Leu Ile Cys His Ile Cys Leu Gln Ala Leu 
        35                  40                  45              


Leu Asp Pro Leu Asp Thr Pro Cys Gly His Thr Tyr Cys Thr Leu Cys 
    50                  55                  60                  


Leu Thr Asn Phe Leu Val Glu Lys Asp Phe Cys Pro Met Asp Arg Lys 
65                  70                  75                  80  


Pro Leu Val Leu Gln His Cys Lys Lys Ser Ser Ile Leu Val Asn Lys 
                85                  90                  95      


Leu Leu Asn Lys Leu Leu Val Thr Cys Pro Phe Arg Glu His Cys Thr 
            100                 105                 110         


Gln Val Leu Gln Arg Cys Asp Leu Glu His His Phe Gln Thr 
        115                 120                 125     


<210>  7944
<211>  728
<212>  PRT
<213>  Homo Sapiens

<400>  7944

Met Asn Gln Pro Glu Ser Ala Asn Asp Pro Glu Pro Leu Cys Ala Val 
1               5                   10                  15      


Cys Gly Gln Ala His Ser Leu Glu Glu Asn His Phe Tyr Ser Tyr Pro 
            20                  25                  30          


Glu Glu Val Asp Asp Asp Leu Ile Cys His Ile Cys Leu Gln Ala Leu 
        35                  40                  45              


Leu Asp Pro Leu Asp Thr Pro Cys Gly His Thr Tyr Cys Thr Leu Cys 
    50                  55                  60                  


Leu Thr Asn Phe Leu Val Glu Lys Asp Phe Cys Pro Met Asp Arg Lys 
65                  70                  75                  80  


Pro Leu Val Leu Gln His Cys Lys Lys Ser Ser Ile Leu Val Asn Lys 
                85                  90                  95      


Leu Leu Asn Lys Leu Leu Val Thr Cys Pro Phe Arg Glu His Cys Thr 
            100                 105                 110         


Gln Val Leu Gln Arg Cys Asp Leu Glu His His Phe Gln Thr Ser Cys 
        115                 120                 125             


Lys Gly Ala Ser His Tyr Gly Leu Thr Lys Asp Arg Lys Arg Arg Ser 
    130                 135                 140                 


Gln Asp Gly Cys Pro Asp Gly Cys Ala Ser Leu Thr Ala Thr Ala Pro 
145                 150                 155                 160 


Ser Pro Glu Val Ser Ala Ala Ala Thr Ile Ser Leu Met Thr Asp Glu 
                165                 170                 175     


Pro Gly Leu Asp Asn Pro Ala Tyr Val Ser Ser Ala Glu Asp Gly Gln 
            180                 185                 190         


Pro Ala Ile Ser Pro Val Asp Ser Gly Arg Ser Asn Arg Thr Arg Ala 
        195                 200                 205             


Arg Pro Phe Glu Arg Ser Thr Ile Arg Ser Arg Ser Phe Lys Lys Ile 
    210                 215                 220                 


Asn Arg Ala Leu Ser Val Leu Arg Arg Thr Lys Ser Gly Ser Ala Val 
225                 230                 235                 240 


Ala Asn His Ala Asp Gln Gly Arg Glu Asn Ser Glu Asn Thr Thr Ala 
                245                 250                 255     


Pro Glu Val Phe Pro Arg Leu Tyr His Leu Ile Pro Asp Gly Glu Ile 
            260                 265                 270         


Thr Ser Ile Lys Ile Asn Arg Val Asp Pro Ser Glu Ser Leu Ser Ile 
        275                 280                 285             


Arg Leu Val Gly Gly Ser Glu Thr Pro Leu Val His Ile Ile Ile Gln 
    290                 295                 300                 


His Ile Tyr Arg Asp Gly Val Ile Ala Arg Asp Gly Arg Leu Leu Pro 
305                 310                 315                 320 


Gly Asp Ile Ile Leu Lys Val Asn Gly Met Asp Ile Ser Asn Val Pro 
                325                 330                 335     


His Asn Tyr Ala Val Arg Leu Leu Arg Gln Pro Cys Gln Val Leu Trp 
            340                 345                 350         


Leu Thr Val Met Arg Glu Gln Lys Phe Arg Ser Arg Asn Asn Gly Gln 
        355                 360                 365             


Ala Pro Asp Ala Tyr Arg Pro Arg Asp Asp Ser Phe His Val Ile Leu 
    370                 375                 380                 


Asn Lys Ser Ser Pro Glu Glu Gln Leu Gly Ile Lys Leu Val Arg Lys 
385                 390                 395                 400 


Val Asp Glu Pro Gly Val Phe Ile Phe Asn Val Leu Asp Gly Gly Val 
                405                 410                 415     


Ala Tyr Arg His Gly Gln Leu Glu Glu Asn Asp Arg Val Leu Ala Ile 
            420                 425                 430         


Asn Gly His Asp Leu Arg Tyr Gly Ser Pro Glu Ser Ala Ala His Leu 
        435                 440                 445             


Ile Gln Ala Ser Glu Arg Arg Val His Leu Val Val Ser Arg Gln Val 
    450                 455                 460                 


Arg Gln Arg Ser Pro Asp Ile Phe Gln Glu Ala Gly Trp Asn Ser Asn 
465                 470                 475                 480 


Gly Ser Trp Ser Pro Gly Pro Gly Glu Arg Ser Asn Thr Pro Lys Pro 
                485                 490                 495     


Leu His Pro Thr Ile Thr Cys His Glu Lys Val Val Asn Ile Gln Lys 
            500                 505                 510         


Asp Pro Gly Glu Ser Leu Gly Met Thr Val Ala Gly Gly Ala Ser His 
        515                 520                 525             


Arg Glu Trp Asp Leu Pro Ile Tyr Val Ile Ser Val Glu Pro Gly Gly 
    530                 535                 540                 


Val Ile Ser Arg Asp Gly Arg Ile Lys Thr Gly Asp Ile Leu Leu Asn 
545                 550                 555                 560 


Val Asp Gly Val Glu Leu Thr Glu Val Ser Arg Ser Glu Ala Val Ala 
                565                 570                 575     


Leu Leu Lys Arg Thr Ser Ser Ser Ile Val Leu Lys Ala Leu Glu Val 
            580                 585                 590         


Lys Glu Tyr Glu Pro Gln Glu Asp Cys Ser Ser Pro Ala Ala Leu Asp 
        595                 600                 605             


Ser Asn His Asn Met Ala Pro Pro Ser Asp Trp Ser Pro Ser Trp Val 
    610                 615                 620                 


Met Trp Leu Glu Leu Pro Arg Cys Leu Tyr Asn Cys Lys Asp Ile Val 
625                 630                 635                 640 


Leu Arg Arg Asn Thr Ala Gly Ser Leu Gly Phe Cys Ile Val Gly Gly 
                645                 650                 655     


Tyr Glu Glu Tyr Asn Gly Asn Lys Pro Phe Phe Ile Lys Ser Ile Val 
            660                 665                 670         


Glu Gly Thr Pro Ala Tyr Asn Asp Gly Arg Ile Arg Cys Gly Asp Ile 
        675                 680                 685             


Leu Leu Ala Val Asn Gly Arg Ser Thr Ser Gly Met Ile His Ala Cys 
    690                 695                 700                 


Leu Ala Arg Leu Leu Lys Glu Leu Lys Gly Arg Ile Thr Leu Thr Ile 
705                 710                 715                 720 


Val Ser Trp Pro Gly Thr Phe Leu 
                725             


<210>  7945
<211>  417
<212>  PRT
<213>  Homo Sapiens

<400>  7945

Met Arg Phe Ala Trp Thr Val Leu Leu Leu Gly Pro Leu Gln Leu Cys 
1               5                   10                  15      


Ala Leu Val His Cys Ala Pro Pro Ala Ala Gly Gln Gln Gln Pro Pro 
            20                  25                  30          


Arg Glu Pro Pro Ala Ala Pro Gly Ala Trp Arg Gln Gln Ile Gln Trp 
        35                  40                  45              


Glu Asn Asn Gly Gln Val Phe Ser Leu Leu Ser Leu Gly Ser Gln Tyr 
    50                  55                  60                  


Gln Pro Gln Arg Arg Arg Asp Pro Gly Ala Ala Val Pro Gly Ala Ala 
65                  70                  75                  80  


Asn Ala Ser Ala Gln Gln Pro Arg Thr Pro Ile Leu Leu Ile Arg Asp 
                85                  90                  95      


Asn Arg Thr Ala Ala Ala Arg Thr Arg Thr Ala Gly Ser Ser Gly Val 
            100                 105                 110         


Thr Ala Gly Arg Pro Arg Pro Thr Ala Arg His Trp Phe Gln Ala Gly 
        115                 120                 125             


Tyr Ser Thr Ser Arg Ala Arg Glu Ala Gly Ala Ser Arg Ala Glu Asn 
    130                 135                 140                 


Gln Thr Ala Pro Gly Glu Val Pro Ala Leu Ser Asn Leu Arg Pro Pro 
145                 150                 155                 160 


Ser Arg Val Asp Gly Met Val Gly Asp Asp Pro Tyr Asn Pro Tyr Lys 
                165                 170                 175     


Tyr Ser Asp Asp Asn Pro Tyr Tyr Asn Tyr Tyr Asp Thr Tyr Glu Arg 
            180                 185                 190         


Pro Arg Pro Gly Gly Arg Tyr Arg Pro Gly Tyr Gly Thr Gly Tyr Phe 
        195                 200                 205             


Gln Tyr Gly Leu Pro Asp Leu Val Ala Asp Pro Tyr Tyr Ile Gln Ala 
    210                 215                 220                 


Ser Thr Tyr Val Gln Lys Met Ser Met Tyr Asn Leu Arg Cys Ala Ala 
225                 230                 235                 240 


Glu Glu Asn Cys Leu Ala Ser Thr Ala Tyr Arg Ala Asp Val Arg Asp 
                245                 250                 255     


Tyr Asp His Arg Val Leu Leu Arg Phe Pro Gln Arg Val Lys Asn Gln 
            260                 265                 270         


Gly Thr Ser Asp Phe Leu Pro Ser Arg Pro Arg Tyr Ser Trp Glu Trp 
        275                 280                 285             


His Ser Cys His Gln His Tyr His Ser Met Asp Glu Phe Ser His Tyr 
    290                 295                 300                 


Asp Leu Leu Asp Ala Asn Thr Gln Arg Arg Val Ala Glu Gly His Lys 
305                 310                 315                 320 


Ala Ser Phe Cys Leu Glu Asp Thr Ser Cys Asp Tyr Gly Tyr His Arg 
                325                 330                 335     


Arg Phe Ala Cys Thr Ala His Thr Gln Gly Leu Ser Pro Gly Cys Tyr 
            340                 345                 350         


Asp Thr Tyr Gly Ala Asp Ile Asp Cys Gln Trp Ile Asp Ile Thr Asp 
        355                 360                 365             


Val Lys Pro Gly Asn Tyr Ile Leu Lys Val Ser Val Asn Pro Ser Tyr 
    370                 375                 380                 


Leu Val Pro Glu Ser Asp Tyr Thr Asn Asn Val Val Arg Cys Asp Ile 
385                 390                 395                 400 


Arg Tyr Thr Gly His His Ala Tyr Ala Ser Gly Cys Thr Ile Ser Pro 
                405                 410                 415     


Tyr 
    


<210>  7946
<211>  417
<212>  PRT
<213>  Homo Sapiens

<400>  7946

Met Arg Phe Ala Trp Thr Val Leu Leu Leu Gly Pro Leu Gln Leu Cys 
1               5                   10                  15      


Ala Leu Val His Cys Ala Pro Pro Ala Ala Gly Gln Gln Gln Pro Pro 
            20                  25                  30          


Arg Glu Pro Pro Ala Ala Pro Gly Ala Trp Arg Gln Gln Ile Gln Trp 
        35                  40                  45              


Glu Asn Asn Gly Gln Val Phe Ser Leu Leu Ser Leu Gly Ser Gln Tyr 
    50                  55                  60                  


Gln Pro Gln Arg Arg Arg Asp Pro Gly Ala Ala Val Pro Gly Ala Ala 
65                  70                  75                  80  


Asn Ala Ser Ala Gln Gln Pro Arg Thr Pro Ile Leu Leu Ile Arg Asp 
                85                  90                  95      


Asn Arg Thr Ala Ala Ala Arg Thr Arg Thr Ala Gly Ser Ser Gly Val 
            100                 105                 110         


Thr Ala Gly Arg Pro Arg Pro Thr Ala Arg His Trp Phe Gln Ala Gly 
        115                 120                 125             


Tyr Ser Thr Ser Arg Ala Arg Glu Ala Gly Ala Ser Arg Ala Glu Asn 
    130                 135                 140                 


Gln Thr Ala Pro Gly Glu Val Pro Ala Leu Ser Asn Leu Arg Pro Pro 
145                 150                 155                 160 


Ser Arg Val Asp Gly Met Val Gly Asp Asp Pro Tyr Asn Pro Tyr Lys 
                165                 170                 175     


Tyr Ser Asp Asp Asn Pro Tyr Tyr Asn Tyr Tyr Asp Thr Tyr Glu Arg 
            180                 185                 190         


Pro Arg Pro Gly Gly Arg Tyr Arg Pro Gly Tyr Gly Thr Gly Tyr Phe 
        195                 200                 205             


Gln Tyr Gly Leu Pro Asp Leu Val Ala Asp Pro Tyr Tyr Ile Gln Ala 
    210                 215                 220                 


Ser Thr Tyr Val Gln Lys Met Ser Met Tyr Asn Leu Arg Cys Ala Ala 
225                 230                 235                 240 


Glu Glu Asn Cys Leu Ala Ser Thr Ala Tyr Arg Ala Asp Val Arg Asp 
                245                 250                 255     


Tyr Asp His Arg Val Leu Leu Arg Phe Pro Gln Arg Val Lys Asn Gln 
            260                 265                 270         


Gly Thr Ser Asp Phe Leu Pro Ser Arg Pro Arg Tyr Ser Trp Glu Trp 
        275                 280                 285             


His Ser Cys His Gln His Tyr His Ser Met Asp Glu Phe Ser His Tyr 
    290                 295                 300                 


Asp Leu Leu Asp Ala Asn Thr Gln Arg Arg Val Ala Glu Gly His Lys 
305                 310                 315                 320 


Ala Ser Phe Cys Leu Glu Asp Thr Ser Cys Asp Tyr Gly Tyr His Arg 
                325                 330                 335     


Arg Phe Ala Cys Thr Ala His Thr Gln Gly Leu Ser Pro Gly Cys Tyr 
            340                 345                 350         


Asp Thr Tyr Gly Ala Asp Ile Asp Cys Gln Trp Ile Asp Ile Thr Asp 
        355                 360                 365             


Val Lys Pro Gly Asn Tyr Ile Leu Lys Val Ser Val Asn Pro Ser Tyr 
    370                 375                 380                 


Leu Val Pro Glu Ser Asp Tyr Thr Asn Asn Val Val Arg Cys Asp Ile 
385                 390                 395                 400 


Arg Tyr Thr Gly His His Ala Tyr Ala Ser Gly Cys Thr Ile Ser Pro 
                405                 410                 415     


Tyr 
    


<210>  7947
<211>  61
<212>  PRT
<213>  Homo Sapiens

<400>  7947

Tyr Asn Pro Tyr Lys Tyr Ser Asp Asp Asn Pro Tyr Tyr Asn Tyr Tyr 
1               5                   10                  15      


Asp Thr Tyr Glu Arg Pro Arg Pro Gly Gly Arg Tyr Arg Pro Gly Tyr 
            20                  25                  30          


Gly Thr Gly Tyr Phe Gln Tyr Val Gln His Thr Gly Gln Met Ser Glu 
        35                  40                  45              


Ile Met Ile Thr Gly Cys Cys Ser Asp Phe Pro Lys Glu 
    50                  55                  60      


<210>  7948
<211>  574
<212>  PRT
<213>  Homo Sapiens

<400>  7948

Met Ala Leu Ala Arg Gly Ser Arg Gln Leu Gly Ala Leu Val Trp Gly 
1               5                   10                  15      


Ala Cys Leu Cys Val Leu Val His Gly Gln Gln Ala Gln Pro Gly Gln 
            20                  25                  30          


Gly Ser Asp Pro Ala Arg Trp Arg Gln Leu Ile Gln Trp Glu Asn Asn 
        35                  40                  45              


Gly Gln Val Tyr Ser Leu Leu Asn Ser Gly Ser Glu Tyr Val Pro Ala 
    50                  55                  60                  


Gly Pro Gln Arg Ser Glu Ser Ser Ser Arg Val Leu Leu Ala Gly Ala 
65                  70                  75                  80  


Pro Gln Ala Gln Gln Arg Arg Ser His Gly Ser Pro Arg Arg Arg Gln 
                85                  90                  95      


Ala Pro Ser Leu Pro Leu Pro Gly Arg Val Gly Ser Asp Thr Val Arg 
            100                 105                 110         


Gly Gln Ala Arg His Pro Phe Gly Phe Gly Gln Val Pro Asp Asn Trp 
        115                 120                 125             


Arg Glu Val Ala Val Gly Asp Ser Thr Gly Met Ala Arg Ala Arg Thr 
    130                 135                 140                 


Ser Val Ser Gln Gln Arg His Gly Gly Ser Ala Ser Ser Val Ser Ala 
145                 150                 155                 160 


Ser Ala Phe Ala Ser Thr Tyr Arg Gln Gln Pro Ser Tyr Pro Gln Gln 
                165                 170                 175     


Phe Pro Tyr Pro Gln Ala Pro Phe Val Ser Gln Tyr Glu Asn Tyr Asp 
            180                 185                 190         


Pro Ala Ser Arg Thr Tyr Asp Gln Gly Phe Val Tyr Tyr Arg Pro Ala 
        195                 200                 205             


Gly Gly Gly Val Gly Ala Gly Ala Ala Ala Val Ala Ser Ala Gly Val 
    210                 215                 220                 


Ile Tyr Pro Tyr Gln Pro Arg Ala Arg Tyr Glu Glu Tyr Gly Gly Gly 
225                 230                 235                 240 


Glu Glu Leu Pro Glu Tyr Pro Pro Gln Gly Phe Tyr Pro Ala Pro Glu 
                245                 250                 255     


Arg Pro Tyr Val Pro Pro Pro Pro Pro Pro Pro Asp Gly Leu Asp Arg 
            260                 265                 270         


Arg Tyr Ser His Ser Leu Tyr Ser Glu Gly Thr Pro Gly Phe Glu Gln 
        275                 280                 285             


Ala Tyr Pro Asp Pro Gly Pro Glu Ala Ala Gln Ala His Gly Gly Asp 
    290                 295                 300                 


Pro Arg Leu Gly Trp Tyr Pro Pro Tyr Ala Asn Pro Pro Pro Glu Ala 
305                 310                 315                 320 


Tyr Gly Pro Pro Arg Ala Leu Glu Pro Pro Tyr Leu Pro Val Arg Ser 
                325                 330                 335     


Ser Asp Thr Pro Pro Pro Gly Gly Glu Arg Asn Gly Ala Gln Gln Gly 
            340                 345                 350         


Arg Leu Ser Val Gly Ser Val Tyr Arg Pro Asn Gln Asn Gly Arg Gly 
        355                 360                 365             


Leu Pro Asp Leu Val Pro Asp Pro Asn Tyr Val Gln Ala Ser Thr Tyr 
    370                 375                 380                 


Val Gln Arg Ala His Leu Tyr Ser Leu Arg Cys Ala Ala Glu Glu Lys 
385                 390                 395                 400 


Cys Leu Ala Ser Thr Ala Tyr Ala Pro Glu Ala Thr Asp Tyr Asp Val 
                405                 410                 415     


Arg Val Leu Leu Arg Phe Pro Gln Arg Val Lys Asn Gln Gly Thr Ala 
            420                 425                 430         


Asp Phe Leu Pro Asn Arg Pro Arg His Thr Trp Glu Trp His Ser Cys 
        435                 440                 445             


His Gln His Tyr His Ser Met Asp Glu Phe Ser His Tyr Asp Leu Leu 
    450                 455                 460                 


Asp Ala Ala Thr Gly Lys Lys Val Ala Glu Gly His Lys Ala Ser Phe 
465                 470                 475                 480 


Cys Leu Glu Asp Ser Thr Cys Asp Phe Gly Asn Leu Lys Arg Tyr Ala 
                485                 490                 495     


Cys Thr Ser His Thr Gln Gly Leu Ser Pro Gly Cys Tyr Asp Thr Tyr 
            500                 505                 510         


Asn Ala Asp Ile Asp Cys Gln Trp Ile Asp Ile Thr Asp Val Gln Pro 
        515                 520                 525             


Gly Asn Tyr Ile Leu Lys Val His Val Asn Pro Lys Tyr Ile Val Leu 
    530                 535                 540                 


Glu Ser Asp Phe Thr Asn Asn Val Val Arg Cys Asn Ile His Tyr Thr 
545                 550                 555                 560 


Gly Arg Tyr Val Ser Ala Thr Asn Cys Lys Ile Val Gln Ser 
                565                 570                 


<210>  7949
<211>  431
<212>  PRT
<213>  Homo Sapiens

<400>  7949

Met Ala Leu Ala Arg Gly Ser Arg Gln Leu Gly Ala Leu Val Trp Gly 
1               5                   10                  15      


Ala Cys Leu Cys Val Leu Val His Gly Gln Gln Ala Gln Pro Gly Gln 
            20                  25                  30          


Gly Ser Asp Pro Ala Arg Trp Arg Gln Leu Ile Gln Trp Glu Asn Asn 
        35                  40                  45              


Gly Gln Val Tyr Ser Leu Leu Asn Ser Gly Ser Glu Tyr Val Pro Ala 
    50                  55                  60                  


Gly Pro Gln Arg Ser Glu Ser Ser Ser Arg Val Leu Leu Ala Gly Ala 
65                  70                  75                  80  


Pro Gln Ala Gln Gln Arg Arg Ser His Gly Ser Pro Arg Arg Arg Gln 
                85                  90                  95      


Ala Pro Ser Leu Pro Leu Pro Gly Arg Val Gly Ser Asp Thr Val Arg 
            100                 105                 110         


Gly Gln Ala Arg His Pro Phe Gly Phe Gly Gln Val Pro Asp Asn Trp 
        115                 120                 125             


Arg Glu Val Ala Val Gly Asp Ser Thr Gly Met Ala Arg Ala Arg Thr 
    130                 135                 140                 


Ser Val Ser Gln Gln Arg His Gly Gly Ser Ala Ser Ser Val Ser Ala 
145                 150                 155                 160 


Ser Ala Phe Ala Ser Thr Tyr Arg Gln Gln Pro Ser Tyr Pro Gln Gln 
                165                 170                 175     


Phe Pro Tyr Pro Gln Ala Pro Phe Val Ser Gln Tyr Glu Asn Tyr Asp 
            180                 185                 190         


Pro Ala Ser Arg Thr Tyr Asp Gln Gly Phe Val Tyr Tyr Arg Pro Ala 
        195                 200                 205             


Gly Gly Gly Val Gly Ala Gly Ala Ala Ala Val Ala Ser Ala Gly Val 
    210                 215                 220                 


Ile Tyr Pro Tyr Gln Pro Arg Ala Arg Tyr Glu Glu Tyr Gly Gly Gly 
225                 230                 235                 240 


Glu Glu Leu Pro Glu Tyr Pro Pro Gln Gly Phe Tyr Pro Ala Pro Glu 
                245                 250                 255     


Arg Pro Tyr Val Pro Pro Pro Pro Pro Pro Pro Asp Gly Leu Asp Arg 
            260                 265                 270         


Arg Tyr Ser His Ser Leu Tyr Ser Glu Gly Thr Pro Gly Phe Glu Gln 
        275                 280                 285             


Ala Tyr Pro Asp Pro Gly Pro Glu Ala Ala Gln Ala His Gly Gly Asp 
    290                 295                 300                 


Pro Arg Leu Gly Trp Tyr Pro Pro Tyr Ala Asn Pro Pro Pro Glu Ala 
305                 310                 315                 320 


Tyr Gly Pro Pro Arg Ala Leu Glu Pro Pro Tyr Leu Pro Val Arg Ser 
                325                 330                 335     


Ser Asp Thr Pro Pro Pro Gly Gly Glu Arg Asn Gly Ala Gln Gln Gly 
            340                 345                 350         


Arg Leu Ser Val Gly Ser Val Tyr Arg Pro Asn Gln Asn Gly Arg Val 
        355                 360                 365             


Thr Pro Ala Gln Thr Pro Ala Cys Pro Gly Arg Lys Val Glu Gly Gln 
    370                 375                 380                 


Glu Gln Asp Gly Gln Ala Pro Gly Ser Gly Thr Ser Trp Gly Thr Arg 
385                 390                 395                 400 


Asp His Lys Asp Gly Gly Ser Leu Gln Thr Ser Pro Gly Arg Leu Thr 
                405                 410                 415     


Pro Gly Leu Ala Gly Glu Arg Ala Arg Ala Ser Leu Arg Ser Pro 
            420                 425                 430     


<210>  7950
<211>  258
<212>  PRT
<213>  Homo Sapiens

<400>  7950

Met Glu Ala Ser Lys Val Leu Asp Lys Ser Lys Ala Ala Ala Ile Gly 
1               5                   10                  15      


Asp Gln Ser Arg Pro Leu Cys Ser Arg Lys Gly Leu Ser Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Pro Pro Trp Arg Ala Arg Ser Gln Pro Gly His Cys 
        35                  40                  45              


Gly Ser Leu Lys Pro Lys Ser Ser Cys Cys Phe Cys Thr Pro Pro Val 
    50                  55                  60                  


Pro Pro Ser Cys Ala Gly Pro Leu Arg Gly Ile Ile Ser Pro Lys Thr 
65                  70                  75                  80  


Gly Met Glu Arg Pro Leu Cys Ser His Leu Cys Ser Cys Leu Ala Met 
                85                  90                  95      


Leu Ala Leu Leu Ser Pro Leu Ser Leu Ala Gln Tyr Asp Ser Trp Pro 
            100                 105                 110         


His Tyr Pro Glu Tyr Phe Gln Gln Pro Ala Pro Glu Tyr His Gln Pro 
        115                 120                 125             


Gln Ala Pro Ala Asn Val Ala Lys Ile Gln Leu Arg Leu Ala Gly Gln 
    130                 135                 140                 


Lys Arg Lys His Ser Glu Gly Arg Val Glu Val Tyr Tyr Asp Gly Gln 
145                 150                 155                 160 


Trp Gly Thr Val Cys Asp Asp Asp Phe Ser Ile His Ala Ala His Val 
                165                 170                 175     


Val Cys Arg Glu Leu Gly Tyr Val Glu Ala Lys Ser Trp Thr Ala Ser 
            180                 185                 190         


Ser Ser Tyr Gly Lys Gly Glu Gly Pro Ile Trp Leu Asp Asn Leu His 
        195                 200                 205             


Cys Thr Gly Asn Glu Ala Thr Leu Ala Ala Cys Thr Ser Asn Gly Trp 
    210                 215                 220                 


Gly Val Thr Asp Cys Lys His Thr Glu Asp Val Gly Val Val Cys Ser 
225                 230                 235                 240 


Asp Lys Arg Ile Pro Gly Phe Lys Phe Asp Asn Ser Leu Ile Asn Gln 
                245                 250                 255     


Ile Glu 
        


<210>  7951
<211>  218
<212>  PRT
<213>  Homo Sapiens

<400>  7951

Met Glu Ala Ser Lys Val Leu Asp Lys Ser Lys Ala Ala Glu Ser Ser 
1               5                   10                  15      


Cys Cys Phe Cys Thr Pro Pro Val Pro Pro Ser Cys Ala Gly Pro Leu 
            20                  25                  30          


Arg Gly Ile Ile Ser Pro Lys Thr Gly Met Glu Arg Pro Leu Cys Ser 
        35                  40                  45              


His Leu Cys Ser Cys Leu Ala Met Leu Ala Leu Leu Ser Pro Leu Ser 
    50                  55                  60                  


Leu Ala Gln Tyr Asp Ser Trp Pro His Tyr Pro Glu Tyr Phe Gln Gln 
65                  70                  75                  80  


Pro Ala Pro Glu Tyr His Gln Pro Gln Ala Pro Ala Asn Val Ala Lys 
                85                  90                  95      


Ile Gln Leu Arg Leu Ala Gly Gln Lys Arg Lys His Ser Glu Gly Arg 
            100                 105                 110         


Val Glu Val Tyr Tyr Asp Gly Gln Trp Gly Thr Val Cys Asp Asp Asp 
        115                 120                 125             


Phe Ser Ile His Ala Ala His Val Val Cys Arg Glu Leu Gly Tyr Val 
    130                 135                 140                 


Glu Ala Lys Ser Trp Thr Ala Ser Ser Ser Tyr Gly Lys Gly Glu Gly 
145                 150                 155                 160 


Pro Ile Trp Leu Asp Asn Leu His Cys Thr Gly Asn Glu Ala Thr Leu 
                165                 170                 175     


Ala Ala Cys Thr Ser Asn Gly Trp Gly Val Thr Asp Cys Lys His Thr 
            180                 185                 190         


Glu Asp Val Gly Val Val Cys Ser Asp Lys Arg Ile Pro Gly Phe Lys 
        195                 200                 205             


Phe Asp Asn Ser Leu Ile Asn Gln Ile Glu 
    210                 215             


<210>  7952
<211>  101
<212>  PRT
<213>  Homo Sapiens

<400>  7952

Met Glu Arg Pro Leu Cys Ser His Leu Cys Ser Cys Leu Ala Met Leu 
1               5                   10                  15      


Ala Leu Leu Ser Pro Leu Ser Leu Ala Gln Tyr Asp Ser Trp Pro His 
            20                  25                  30          


Tyr Pro Glu Tyr Phe Gln Gln Pro Ala Pro Glu Tyr His Gln Pro Gln 
        35                  40                  45              


Ala Pro Ala Asn Val Ala Lys Ile Gln Leu His Leu Val Leu Ala Arg 
    50                  55                  60                  


Arg Cys Gln Gln Gln Gln Ser Gly His Glu Trp Ser Glu Val Leu Gly 
65                  70                  75                  80  


Asn Gly Ala Val Pro Gly Ala Leu Pro Pro Arg Arg Gly Gly Arg Gly 
                85                  90                  95      


Leu Pro Pro Gly Arg 
            100     


<210>  7953
<211>  96
<212>  PRT
<213>  Homo Sapiens

<400>  7953

Met Glu Arg Pro Leu Cys Ser His Leu Cys Ser Cys Leu Ala Met Leu 
1               5                   10                  15      


Ala Leu Leu Ser Pro Leu Ser Leu Ala Gln Tyr Asp Ser Trp Pro His 
            20                  25                  30          


Tyr Pro Glu Tyr Phe Gln Gln Pro Ala Pro Glu Tyr His Gln Pro Gln 
        35                  40                  45              


Ala Pro Ala Asn Val Ala Lys Ile Gln Leu Arg Leu Ala Gly Gln Lys 
    50                  55                  60                  


Arg Lys His Ser Glu Gly Arg Val Glu Val Tyr Tyr Asp Gly Gln Trp 
65                  70                  75                  80  


Gly Thr Val Cys Asp Asp Asp Phe Ser Ile His Ala Ala His Val Val 
                85                  90                  95      


<210>  7954
<211>  139
<212>  PRT
<213>  Homo Sapiens

<400>  7954

Met Glu Arg Pro Leu Cys Ser His Leu Cys Ser Cys Leu Ala Met Leu 
1               5                   10                  15      


Ala Leu Leu Ser Pro Leu Ser Leu Ala Gln Tyr Asp Ser Trp Pro His 
            20                  25                  30          


Tyr Pro Glu Tyr Phe Gln Gln Pro Ala Pro Glu Tyr His Gln Pro Gln 
        35                  40                  45              


Ala Pro Ala Asn Val Ala Lys Ile Gln Leu Arg Leu Ala Gly Gln Lys 
    50                  55                  60                  


Arg Lys His Ser Glu Gly Arg Val Glu Val Tyr Tyr Asp Gly Gln Trp 
65                  70                  75                  80  


Gly Thr Val Cys Asp Asp Asp Phe Ser Ile His Ala Ala His Val Val 
                85                  90                  95      


Cys Arg Glu Leu Gly Tyr Val Glu Ala Lys Ser Trp Thr Ala Ser Ser 
            100                 105                 110         


Ser Tyr Gly Lys Gly Glu Gly Pro Ile Trp Leu Asp Asn Leu His Cys 
        115                 120                 125             


Thr Gly Asn Glu Ala Thr Leu Ala Ala Cys Thr 
    130                 135                 


<210>  7955
<211>  151
<212>  PRT
<213>  Homo Sapiens

<400>  7955

Met Glu Arg Pro Leu Cys Ser His Leu Cys Ser Cys Leu Ala Met Leu 
1               5                   10                  15      


Ala Leu Leu Ser Pro Leu Ser Leu Ala Gln Tyr Asp Ser Trp Pro His 
            20                  25                  30          


Tyr Pro Glu Tyr Phe Gln Gln Pro Ala Pro Glu Tyr His Gln Pro Gln 
        35                  40                  45              


Ala Pro Ala Asn Val Ala Lys Ile Gln Leu Arg Leu Ala Gly Gln Lys 
    50                  55                  60                  


Arg Lys His Ser Glu Gly Arg Val Glu Val Tyr Tyr Asp Gly Gln Trp 
65                  70                  75                  80  


Gly Thr Val Cys Asp Asp Asp Phe Ser Ile His Ala Ala His Val Val 
                85                  90                  95      


Cys Arg Glu Leu Gly Tyr Val Glu Ala Lys Ser Trp Thr Ala Ser Ser 
            100                 105                 110         


Ser Tyr Gly Lys Gly Glu Gly Pro Ile Trp Leu Asp Asn Leu His Cys 
        115                 120                 125             


Thr Gly Asn Glu Ala Thr Leu Ala Ala Cys Thr Ser Asn Gly Trp Gly 
    130                 135                 140                 


Val Thr Asp Cys Lys His Thr 
145                 150     


<210>  7956
<211>  774
<212>  PRT
<213>  Homo Sapiens

<400>  7956

Met Glu Arg Pro Leu Cys Ser His Leu Cys Ser Cys Leu Ala Met Leu 
1               5                   10                  15      


Ala Leu Leu Ser Pro Leu Ser Leu Ala Gln Tyr Asp Ser Trp Pro His 
            20                  25                  30          


Tyr Pro Glu Tyr Phe Gln Gln Pro Ala Pro Glu Tyr His Gln Pro Gln 
        35                  40                  45              


Ala Pro Ala Asn Val Ala Lys Ile Gln Leu Arg Leu Ala Gly Gln Lys 
    50                  55                  60                  


Arg Lys His Ser Glu Gly Arg Val Glu Val Tyr Tyr Asp Gly Gln Trp 
65                  70                  75                  80  


Gly Thr Val Cys Asp Asp Asp Phe Ser Ile His Ala Ala His Val Val 
                85                  90                  95      


Cys Arg Glu Leu Gly Tyr Val Glu Ala Lys Ser Trp Thr Ala Ser Ser 
            100                 105                 110         


Ser Tyr Gly Lys Gly Glu Gly Pro Ile Trp Leu Asp Asn Leu His Cys 
        115                 120                 125             


Thr Gly Asn Glu Ala Thr Leu Ala Ala Cys Thr Ser Asn Gly Trp Gly 
    130                 135                 140                 


Val Thr Asp Cys Lys His Thr Glu Asp Val Gly Val Val Cys Ser Asp 
145                 150                 155                 160 


Lys Arg Ile Pro Gly Phe Lys Phe Asp Asn Ser Leu Ile Asn Gln Ile 
                165                 170                 175     


Glu Asn Leu Asn Ile Gln Val Glu Asp Ile Arg Ile Arg Ala Ile Leu 
            180                 185                 190         


Ser Thr Tyr Arg Lys Arg Thr Pro Val Met Glu Gly Tyr Val Glu Val 
        195                 200                 205             


Lys Glu Gly Lys Thr Trp Lys Gln Ile Cys Asp Lys His Trp Thr Ala 
    210                 215                 220                 


Lys Asn Ser Arg Val Val Cys Gly Met Phe Gly Phe Pro Gly Glu Arg 
225                 230                 235                 240 


Thr Tyr Asn Thr Lys Val Tyr Lys Met Phe Ala Ser Arg Arg Lys Gln 
                245                 250                 255     


Arg Tyr Trp Pro Phe Ser Met Asp Cys Thr Gly Thr Glu Ala His Ile 
            260                 265                 270         


Ser Ser Cys Lys Leu Gly Pro Gln Val Ser Leu Asp Pro Met Lys Asn 
        275                 280                 285             


Val Thr Cys Glu Asn Gly Leu Pro Ala Val Val Ser Cys Val Pro Gly 
    290                 295                 300                 


Gln Val Phe Ser Pro Asp Gly Pro Ser Arg Phe Arg Lys Ala Tyr Lys 
305                 310                 315                 320 


Pro Glu Gln Pro Leu Val Arg Leu Arg Gly Gly Ala Tyr Ile Gly Glu 
                325                 330                 335     


Gly Arg Val Glu Val Leu Lys Asn Gly Glu Trp Gly Thr Val Cys Asp 
            340                 345                 350         


Asp Lys Trp Asp Leu Val Ser Ala Ser Val Val Cys Arg Glu Leu Gly 
        355                 360                 365             


Phe Gly Ser Ala Lys Glu Ala Val Thr Gly Ser Arg Leu Gly Gln Gly 
    370                 375                 380                 


Ile Gly Pro Ile His Leu Asn Glu Ile Gln Cys Thr Gly Asn Glu Lys 
385                 390                 395                 400 


Ser Ile Ile Asp Cys Lys Phe Asn Ala Glu Ser Gln Gly Cys Asn His 
                405                 410                 415     


Glu Glu Asp Ala Gly Val Arg Cys Asn Thr Pro Ala Met Gly Leu Gln 
            420                 425                 430         


Lys Lys Leu Arg Leu Asn Gly Gly Arg Asn Pro Tyr Glu Gly Arg Val 
        435                 440                 445             


Glu Val Leu Val Glu Arg Asn Gly Ser Leu Val Trp Gly Met Val Cys 
    450                 455                 460                 


Gly Gln Asn Trp Gly Ile Val Glu Ala Met Val Val Cys Arg Gln Leu 
465                 470                 475                 480 


Gly Leu Gly Phe Ala Ser Asn Ala Phe Gln Glu Thr Trp Tyr Trp His 
                485                 490                 495     


Gly Asp Val Asn Ser Asn Lys Val Val Met Ser Gly Val Lys Cys Ser 
            500                 505                 510         


Gly Thr Glu Leu Ser Leu Ala His Cys Arg His Asp Gly Glu Asp Val 
        515                 520                 525             


Ala Cys Pro Gln Gly Gly Val Gln Tyr Gly Ala Gly Val Ala Cys Ser 
    530                 535                 540                 


Glu Thr Ala Pro Asp Leu Val Leu Asn Ala Glu Met Val Gln Gln Thr 
545                 550                 555                 560 


Thr Tyr Leu Glu Asp Arg Pro Met Phe Met Leu Gln Cys Ala Met Glu 
                565                 570                 575     


Glu Asn Cys Leu Ser Ala Ser Ala Ala Gln Thr Asp Pro Thr Thr Gly 
            580                 585                 590         


Tyr Arg Arg Leu Leu Arg Phe Ser Ser Gln Ile His Asn Asn Gly Gln 
        595                 600                 605             


Ser Asp Phe Arg Pro Lys Asn Gly Arg His Ala Trp Ile Trp His Asp 
    610                 615                 620                 


Cys His Arg His Tyr His Ser Met Glu Val Phe Thr His Tyr Asp Leu 
625                 630                 635                 640 


Leu Asn Leu Asn Gly Thr Lys Val Ala Glu Gly His Lys Ala Ser Phe 
                645                 650                 655     


Cys Leu Glu Asp Thr Glu Cys Glu Gly Asp Ile Gln Lys Asn Tyr Glu 
            660                 665                 670         


Cys Ala Asn Phe Gly Asp Gln Gly Ile Thr Met Gly Cys Trp Asp Met 
        675                 680                 685             


Tyr Arg His Asp Ile Asp Cys Gln Trp Val Asp Ile Thr Asp Val Pro 
    690                 695                 700                 


Pro Gly Asp Tyr Leu Phe Gln Val Val Ile Asn Pro Asn Phe Glu Val 
705                 710                 715                 720 


Ala Glu Ser Asp Tyr Ser Asn Asn Ile Met Lys Cys Arg Ser Arg Tyr 
                725                 730                 735     


Asp Gly His Arg Ile Trp Met Tyr Asn Cys His Ile Gly Gly Ser Phe 
            740                 745                 750         


Ser Glu Glu Thr Glu Lys Lys Phe Glu His Phe Ser Gly Leu Leu Asn 
        755                 760                 765             


Asn Gln Leu Ser Pro Gln 
    770                 


<210>  7957
<211>  67
<212>  PRT
<213>  Homo Sapiens

<400>  7957

Arg Ile Arg Ala Ile Leu Ser Thr Tyr Arg Lys Arg Thr Pro Val Met 
1               5                   10                  15      


Glu Gly Tyr Val Glu Val Lys Glu Gly Lys Thr Trp Lys Gln Ile Cys 
            20                  25                  30          


Asp Lys His Trp Thr Ala Lys Asn Ser Arg Val Val Cys Gly Met Phe 
        35                  40                  45              


Gly Phe Pro Gly Glu Arg Thr Tyr Asn Thr Lys Val Tyr Asn Asn Pro 
    50                  55                  60                  


Trp Cys Asp 
65          


<210>  7958
<211>  207
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7958

Xaa Glu Asn Gly Leu Pro Ala Val Val Ser Cys Val Pro Gly Gln Val 
1               5                   10                  15      


Phe Ser Pro Asp Gly Pro Ser Arg Phe Arg Lys Ala Tyr Lys Pro Glu 
            20                  25                  30          


Gln Asp Arg Val Ser Leu Gln Gln Pro Leu Val Arg Leu Arg Gly Gly 
        35                  40                  45              


Ala Tyr Ile Gly Glu Gly Arg Val Glu Val Leu Lys Asn Gly Glu Trp 
    50                  55                  60                  


Gly Thr Val Cys Asp Asp Lys Trp Asp Leu Val Ser Ala Ser Val Val 
65                  70                  75                  80  


Cys Arg Glu Leu Gly Phe Gly Ser Ala Lys Glu Ala Val Thr Gly Ser 
                85                  90                  95      


Arg Leu Gly Gln Gly Ile Gly Pro Ile His Leu Asn Glu Ile Gln Cys 
            100                 105                 110         


Thr Gly Asn Glu Lys Ser Ile Ile Asp Cys Lys Phe Asn Ala Glu Ser 
        115                 120                 125             


Gln Gly Cys Asn His Glu Glu Asp Ala Gly Val Arg Cys Asn Thr Pro 
    130                 135                 140                 


Ala Met Gly Leu Gln Lys Lys Leu Arg Leu Asn Gly Gly Arg Asn Pro 
145                 150                 155                 160 


Tyr Glu Gly Arg Val Glu Val Leu Val Glu Arg Asn Gly Ser Leu Val 
                165                 170                 175     


Trp Gly Met Val Cys Gly Gln Asn Trp Gly Ile Val Glu Ala Met Val 
            180                 185                 190         


Val Cys Arg Gln Leu Gly Leu Gly Phe Ala Ser Asn Ala Phe Gln 
        195                 200                 205         


<210>  7959
<211>  586
<212>  PRT
<213>  Homo Sapiens

<400>  7959

Met Arg Pro Val Ser Val Trp Gln Trp Ser Pro Trp Gly Leu Leu Leu 
1               5                   10                  15      


Cys Leu Leu Cys Ser Ser Cys Leu Gly Ser Pro Ser Pro Ser Thr Gly 
            20                  25                  30          


Pro Glu Lys Lys Ala Gly Ser Gln Gly Leu Arg Phe Arg Leu Ala Gly 
        35                  40                  45              


Phe Pro Arg Lys Pro Tyr Glu Gly Arg Val Glu Ile Gln Arg Ala Gly 
    50                  55                  60                  


Glu Trp Gly Thr Ile Cys Asp Asp Asp Phe Thr Leu Gln Ala Ala His 
65                  70                  75                  80  


Ile Leu Cys Arg Glu Leu Gly Phe Thr Glu Ala Thr Gly Trp Thr His 
                85                  90                  95      


Ser Ala Lys Tyr Gly Pro Gly Thr Gly Arg Ile Trp Leu Asp Asn Leu 
            100                 105                 110         


Ser Cys Ser Gly Thr Glu Gln Ser Val Thr Glu Cys Ala Ser Arg Gly 
        115                 120                 125             


Trp Gly Asn Ser Asp Cys Thr His Asp Glu Asp Ala Gly Val Ile Cys 
    130                 135                 140                 


Lys Asp Gln Arg Leu Pro Gly Phe Ser Asp Ser Asn Val Ile Glu Ala 
145                 150                 155                 160 


Arg Val Arg Leu Lys Gly Gly Ala His Pro Gly Glu Gly Arg Val Glu 
                165                 170                 175     


Val Leu Lys Ala Ser Thr Trp Gly Thr Val Cys Asp Arg Lys Trp Asp 
            180                 185                 190         


Leu His Ala Ala Ser Val Val Cys Arg Glu Leu Gly Phe Gly Ser Ala 
        195                 200                 205             


Arg Glu Ala Leu Ser Gly Ala Arg Met Gly Gln Gly Met Gly Ala Ile 
    210                 215                 220                 


His Leu Ser Glu Val Arg Cys Ser Gly Gln Glu Leu Ser Leu Trp Lys 
225                 230                 235                 240 


Cys Pro His Lys Asn Ile Thr Ala Glu Asp Cys Ser His Ser Gln Asp 
                245                 250                 255     


Ala Gly Val Arg Cys Asn Leu Pro Tyr Thr Gly Ala Glu Thr Arg Ile 
            260                 265                 270         


Arg Leu Ser Gly Gly Arg Ser Gln His Glu Gly Arg Val Glu Val Gln 
        275                 280                 285             


Ile Gly Gly Pro Gly Pro Leu Arg Trp Gly Leu Ile Cys Gly Asp Asp 
    290                 295                 300                 


Trp Gly Thr Leu Glu Ala Met Val Ala Cys Arg Gln Leu Gly Leu Gly 
305                 310                 315                 320 


Tyr Ala Asn His Gly Leu Gln Glu Thr Trp Tyr Trp Asp Ser Gly Asn 
                325                 330                 335     


Ile Thr Glu Val Val Met Ser Gly Val Arg Cys Thr Gly Thr Glu Leu 
            340                 345                 350         


Ser Leu Asp Gln Cys Ala His His Gly Thr His Ile Thr Cys Lys Arg 
        355                 360                 365             


Thr Gly Thr Arg Phe Thr Ala Gly Val Ile Cys Ser Glu Thr Ala Ser 
    370                 375                 380                 


Asp Leu Leu Leu His Ser Ala Leu Val Gln Glu Thr Ala Tyr Ile Glu 
385                 390                 395                 400 


Asp Arg Pro Leu His Met Leu Tyr Cys Ala Ala Glu Glu Asn Cys Leu 
                405                 410                 415     


Ala Ser Ser Ala Arg Ser Ala Asn Trp Pro Tyr Gly His Arg Arg Leu 
            420                 425                 430         


Leu Arg Phe Ser Ser Gln Ile His Asn Leu Gly Arg Ala Asp Phe Arg 
        435                 440                 445             


Pro Lys Ala Gly Arg His Ser Trp Val Trp His Glu Cys His Gly His 
    450                 455                 460                 


Tyr His Ser Met Asp Ile Phe Thr His Tyr Asp Ile Leu Thr Pro Asn 
465                 470                 475                 480 


Gly Thr Lys Val Ala Glu Gly His Lys Ala Ser Phe Cys Leu Glu Asp 
                485                 490                 495     


Thr Glu Cys Gln Glu Asp Val Ser Lys Arg Tyr Glu Cys Ala Asn Phe 
            500                 505                 510         


Gly Glu Gln Gly Ile Thr Val Gly Cys Trp Asp Leu Tyr Arg His Asp 
        515                 520                 525             


Ile Asp Cys Gln Trp Ile Asp Ile Thr Asp Val Lys Pro Gly Asn Tyr 
    530                 535                 540                 


Ile Leu Gln Val Val Ile Asn Pro Asn Phe Glu Val Ala Glu Ser Asp 
545                 550                 555                 560 


Phe Thr Asn Asn Ala Met Lys Cys Asn Cys Lys Tyr Asp Gly His Arg 
                565                 570                 575     


Ile Trp Val His Asn Cys His Ile Gly Ile 
            580                 585     


<210>  7960
<211>  608
<212>  PRT
<213>  Homo Sapiens

<400>  7960

Met Arg Pro Val Ser Val Trp Gln Trp Ser Pro Trp Gly Leu Leu Leu 
1               5                   10                  15      


Cys Leu Leu Cys Ser Ser Cys Leu Gly Ser Pro Ser Pro Ser Thr Gly 
            20                  25                  30          


Pro Glu Lys Lys Ala Gly Ser Gln Gly Leu Arg Phe Arg Leu Ala Gly 
        35                  40                  45              


Phe Pro Arg Lys Pro Tyr Glu Gly Arg Val Glu Ile Gln Arg Ala Gly 
    50                  55                  60                  


Glu Trp Gly Thr Ile Cys Asp Asp Asp Phe Thr Leu Gln Ala Ala His 
65                  70                  75                  80  


Ile Leu Cys Arg Glu Leu Gly Phe Thr Glu Ala Thr Gly Trp Thr His 
                85                  90                  95      


Ser Ala Lys Tyr Gly Pro Gly Thr Gly Arg Ile Trp Leu Asp Asn Leu 
            100                 105                 110         


Ser Cys Ser Gly Thr Glu Gln Ser Val Thr Glu Cys Ala Ser Arg Gly 
        115                 120                 125             


Trp Gly Asn Ser Asp Cys Thr His Asp Glu Asp Ala Gly Val Ile Cys 
    130                 135                 140                 


Lys Asp Gln Arg Leu Pro Gly Phe Ser Asp Ser Asn Val Ile Glu Ala 
145                 150                 155                 160 


Arg Val Arg Leu Lys Gly Gly Ala His Pro Gly Glu Gly Arg Val Glu 
                165                 170                 175     


Val Leu Lys Ala Ser Thr Trp Gly Thr Val Cys Asp Arg Lys Trp Asp 
            180                 185                 190         


Leu His Ala Ala Ser Val Val Cys Arg Glu Leu Gly Phe Gly Ser Ala 
        195                 200                 205             


Arg Glu Ala Leu Ser Gly Ala Arg Met Gly Gln Gly Met Gly Ala Ile 
    210                 215                 220                 


His Leu Ser Glu Val Arg Cys Ser Gly Gln Glu Leu Ser Leu Trp Lys 
225                 230                 235                 240 


Cys Pro His Lys Asn Ile Thr Ala Glu Asp Cys Ser His Ser Gln Asp 
                245                 250                 255     


Ala Gly Val Arg Cys Asn Leu Pro Tyr Thr Gly Ala Glu Thr Arg Ile 
            260                 265                 270         


Arg Leu Ser Gly Gly Arg Ser Gln His Glu Gly Arg Val Glu Val Gln 
        275                 280                 285             


Ile Gly Gly Pro Gly Pro Leu Arg Trp Gly Leu Ile Cys Gly Asp Asp 
    290                 295                 300                 


Trp Gly Thr Leu Glu Ala Met Val Ala Cys Arg Gln Leu Gly Leu Gly 
305                 310                 315                 320 


Tyr Ala Asn His Gly Leu Gln Glu Thr Trp Tyr Trp Asp Ser Gly Asn 
                325                 330                 335     


Ile Thr Glu Val Val Met Ser Gly Val Arg Cys Thr Gly Thr Glu Leu 
            340                 345                 350         


Ser Leu Asp Gln Cys Ala His His Gly Thr His Ile Thr Cys Lys Arg 
        355                 360                 365             


Thr Gly Thr Arg Phe Thr Ala Gly Val Ile Cys Ser Glu Thr Ala Ser 
    370                 375                 380                 


Asp Leu Leu Leu His Ser Ala Leu Val Gln Glu Thr Ala Tyr Ile Glu 
385                 390                 395                 400 


Asp Arg Pro Leu His Met Leu Tyr Cys Ala Ala Glu Glu Asn Cys Leu 
                405                 410                 415     


Ala Ser Ser Ala Arg Ser Ala Asn Trp Pro Tyr Gly His Arg Arg Leu 
            420                 425                 430         


Leu Arg Phe Ser Ser Gln Ile His Asn Leu Gly Arg Ala Asp Phe Arg 
        435                 440                 445             


Pro Lys Ala Gly Arg His Ser Trp Val Trp His Glu Cys His Gly His 
    450                 455                 460                 


Tyr His Ser Met Asp Ile Phe Thr His Tyr Asp Ile Leu Thr Pro Asn 
465                 470                 475                 480 


Gly Thr Lys Val Ala Glu Gly His Lys Ala Ser Phe Cys Leu Glu Asp 
                485                 490                 495     


Thr Glu Cys Gln Glu Asp Val Ser Lys Arg Tyr Glu Cys Ala Asn Phe 
            500                 505                 510         


Gly Glu Gln Gly Ile Thr Val Gly Cys Trp Asp Leu Tyr Arg His Asp 
        515                 520                 525             


Ile Asp Cys Gln Trp Ile Asp Ile Thr Asp Val Lys Pro Gly Asn Tyr 
    530                 535                 540                 


Ile Leu Gln Val Val Ile Asn Pro Asn Phe Glu Val Ala Glu Ser Asp 
545                 550                 555                 560 


Phe Thr Asn Asn Ala Met Lys Cys Asn Cys Lys Tyr Asp Gly His Arg 
                565                 570                 575     


Ile Trp Val His Asn Cys His Ile Gly Asp Ala Phe Ser Glu Glu Ala 
            580                 585                 590         


Asn Arg Arg Phe Glu Arg Tyr Pro Gly Gln Thr Ser Asn Gln Ile Ile 
        595                 600                 605             


<210>  7961
<211>  753
<212>  PRT
<213>  Homo Sapiens

<400>  7961

Met Arg Pro Val Ser Val Trp Gln Trp Ser Pro Trp Gly Leu Leu Leu 
1               5                   10                  15      


Cys Leu Leu Cys Ser Ser Cys Leu Gly Ser Pro Ser Pro Ser Thr Gly 
            20                  25                  30          


Pro Glu Lys Lys Ala Gly Ser Gln Gly Leu Arg Phe Arg Leu Ala Gly 
        35                  40                  45              


Phe Pro Arg Lys Pro Tyr Glu Gly Arg Val Glu Ile Gln Arg Ala Gly 
    50                  55                  60                  


Glu Trp Gly Thr Ile Cys Asp Asp Asp Phe Thr Leu Gln Ala Ala His 
65                  70                  75                  80  


Ile Leu Cys Arg Glu Leu Gly Phe Thr Glu Ala Thr Gly Trp Thr His 
                85                  90                  95      


Ser Ala Lys Tyr Gly Pro Gly Thr Gly Arg Ile Trp Leu Asp Asn Leu 
            100                 105                 110         


Ser Cys Ser Gly Thr Glu Gln Ser Val Thr Glu Cys Ala Ser Arg Gly 
        115                 120                 125             


Trp Gly Asn Ser Asp Cys Thr His Asp Glu Asp Ala Gly Val Ile Cys 
    130                 135                 140                 


Lys Asp Gln Arg Leu Pro Gly Phe Ser Asp Ser Asn Val Ile Glu Val 
145                 150                 155                 160 


Glu His His Leu Gln Val Glu Glu Val Arg Ile Arg Pro Ala Val Gly 
                165                 170                 175     


Trp Gly Arg Arg Pro Leu Pro Val Thr Glu Gly Leu Val Glu Val Arg 
            180                 185                 190         


Leu Pro Asp Gly Trp Ser Gln Val Cys Asp Lys Gly Trp Ser Ala His 
        195                 200                 205             


Asn Ser His Val Val Cys Gly Met Leu Gly Phe Pro Ser Glu Lys Arg 
    210                 215                 220                 


Val Asn Ala Ala Phe Tyr Arg Leu Leu Ala Gln Arg Gln Gln His Ser 
225                 230                 235                 240 


Phe Gly Leu His Gly Val Ala Cys Val Gly Thr Glu Ala His Leu Ser 
                245                 250                 255     


Leu Cys Ser Leu Glu Phe Tyr Arg Ala Asn Asp Thr Ala Arg Cys Pro 
            260                 265                 270         


Gly Gly Gly Pro Ala Val Val Ser Cys Val Pro Gly Pro Val Tyr Ala 
        275                 280                 285             


Ala Ser Ser Gly Gln Lys Lys Gln Gln Gln Ser Lys Pro Gln Gly Glu 
    290                 295                 300                 


Ala Arg Val Arg Leu Lys Gly Gly Ala His Pro Gly Glu Gly Arg Val 
305                 310                 315                 320 


Glu Val Leu Lys Ala Ser Thr Trp Gly Thr Val Cys Asp Arg Lys Trp 
                325                 330                 335     


Asp Leu His Ala Ala Ser Val Val Cys Arg Glu Leu Gly Phe Gly Ser 
            340                 345                 350         


Ala Arg Glu Ala Leu Ser Gly Ala Arg Met Gly Gln Gly Met Gly Ala 
        355                 360                 365             


Ile His Leu Ser Glu Val Arg Cys Ser Gly Gln Glu Leu Ser Leu Trp 
    370                 375                 380                 


Lys Cys Pro His Lys Asn Ile Thr Ala Glu Asp Cys Ser His Ser Gln 
385                 390                 395                 400 


Asp Ala Gly Val Arg Cys Asn Leu Pro Tyr Thr Gly Ala Glu Thr Arg 
                405                 410                 415     


Ile Arg Leu Ser Gly Gly Arg Ser Gln His Glu Gly Arg Val Glu Val 
            420                 425                 430         


Gln Ile Gly Gly Pro Gly Pro Leu Arg Trp Gly Leu Ile Cys Gly Asp 
        435                 440                 445             


Asp Trp Gly Thr Leu Glu Ala Met Val Ala Cys Arg Gln Leu Gly Leu 
    450                 455                 460                 


Gly Tyr Ala Asn His Gly Leu Gln Glu Thr Trp Tyr Trp Asp Ser Gly 
465                 470                 475                 480 


Asn Ile Thr Glu Val Val Met Ser Gly Val Arg Cys Thr Gly Thr Glu 
                485                 490                 495     


Leu Ser Leu Asp Gln Cys Ala His His Gly Thr His Ile Thr Cys Lys 
            500                 505                 510         


Arg Thr Gly Thr Arg Phe Thr Ala Gly Val Ile Cys Ser Glu Thr Ala 
        515                 520                 525             


Ser Asp Leu Leu Leu His Ser Ala Leu Val Gln Glu Thr Ala Tyr Ile 
    530                 535                 540                 


Glu Asp Arg Pro Leu His Met Leu Tyr Cys Ala Ala Glu Glu Asn Cys 
545                 550                 555                 560 


Leu Ala Ser Ser Ala Arg Ser Ala Asn Trp Pro Tyr Gly His Arg Arg 
                565                 570                 575     


Leu Leu Arg Phe Ser Ser Gln Ile His Asn Leu Gly Arg Ala Asp Phe 
            580                 585                 590         


Arg Pro Lys Ala Gly Arg His Ser Trp Val Trp His Glu Cys His Gly 
        595                 600                 605             


His Tyr His Ser Met Asp Ile Phe Thr His Tyr Asp Ile Leu Thr Pro 
    610                 615                 620                 


Asn Gly Thr Lys Val Ala Glu Gly His Lys Ala Ser Phe Cys Leu Glu 
625                 630                 635                 640 


Asp Thr Glu Cys Gln Glu Asp Val Ser Lys Arg Tyr Glu Cys Ala Asn 
                645                 650                 655     


Phe Gly Glu Gln Gly Ile Thr Val Gly Cys Trp Asp Leu Tyr Arg His 
            660                 665                 670         


Asp Ile Asp Cys Gln Trp Ile Asp Ile Thr Asp Val Lys Pro Gly Asn 
        675                 680                 685             


Tyr Ile Leu Gln Val Val Ile Asn Pro Asn Phe Glu Val Ala Glu Ser 
    690                 695                 700                 


Asp Phe Thr Asn Asn Ala Met Lys Cys Asn Cys Lys Tyr Asp Gly His 
705                 710                 715                 720 


Arg Ile Trp Val His Asn Cys His Ile Gly Asp Ala Phe Ser Glu Glu 
                725                 730                 735     


Ala Asn Arg Arg Phe Glu Arg Tyr Pro Gly Gln Thr Ser Asn Gln Ile 
            740                 745                 750         


Ile 
    


<210>  7962
<211>  303
<212>  PRT
<213>  Homo Sapiens

<400>  7962

Met Arg Pro Val Ser Val Trp Gln Trp Ser Pro Trp Gly Leu Leu Leu 
1               5                   10                  15      


Cys Leu Leu Cys Ser Ser Cys Leu Gly Ser Pro Ser Pro Ser Thr Gly 
            20                  25                  30          


Pro Glu Lys Lys Ala Gly Ser Gln Gly Leu Arg Phe Arg Leu Ala Gly 
        35                  40                  45              


Phe Pro Arg Lys Pro Tyr Glu Gly Arg Val Glu Ile Gln Arg Ala Gly 
    50                  55                  60                  


Glu Trp Gly Thr Ile Cys Asp Asp Asp Phe Thr Leu Gln Ala Ala His 
65                  70                  75                  80  


Ile Leu Cys Arg Glu Leu Gly Phe Thr Glu Ala Thr Gly Trp Thr His 
                85                  90                  95      


Ser Ala Lys Tyr Gly Pro Gly Thr Gly Arg Ile Trp Leu Asp Asn Leu 
            100                 105                 110         


Ser Cys Ser Gly Thr Glu Gln Ser Val Thr Glu Cys Ala Ser Arg Gly 
        115                 120                 125             


Trp Gly Asn Ser Asp Cys Thr His Asp Glu Asp Ala Gly Val Ile Cys 
    130                 135                 140                 


Lys Asp Gln Arg Leu Pro Gly Phe Ser Asp Ser Asn Val Ile Glu Val 
145                 150                 155                 160 


Glu His His Leu Gln Val Glu Glu Val Arg Ile Arg Pro Ala Val Gly 
                165                 170                 175     


Trp Gly Arg Arg Pro Leu Pro Val Thr Glu Gly Leu Val Glu Val Arg 
            180                 185                 190         


Leu Pro Asp Gly Trp Ser Gln Val Cys Asp Lys Gly Trp Ser Ala His 
        195                 200                 205             


Asn Ser His Val Val Cys Gly Met Leu Gly Phe Pro Ser Glu Lys Arg 
    210                 215                 220                 


Val Asn Ala Ala Phe Tyr Arg Leu Leu Ala Gln Arg Gln Gln His Ser 
225                 230                 235                 240 


Phe Gly Leu His Gly Val Ala Cys Val Gly Thr Glu Ala His Leu Ser 
                245                 250                 255     


Leu Cys Ser Leu Glu Phe Tyr Arg Ala Asn Asp Thr Ala Arg Cys Pro 
            260                 265                 270         


Gly Gly Gly Pro Ala Val Val Ser Cys Val Pro Gly Pro Val Tyr Ala 
        275                 280                 285             


Ala Ser Ser Gly Gln Lys Lys Gln Gln Gln Ser Lys Pro Gln Gly 
    290                 295                 300             


<210>  7963
<211>  471
<212>  PRT
<213>  Homo Sapiens

<400>  7963

Met Arg Pro Val Ser Val Trp Gln Trp Ser Pro Trp Gly Leu Leu Leu 
1               5                   10                  15      


Cys Leu Leu Cys Ser Ser Cys Leu Gly Ser Pro Ser Pro Ser Thr Gly 
            20                  25                  30          


Pro Glu Lys Lys Ala Gly Ser Gln Gly Leu Arg Phe Arg Leu Ala Gly 
        35                  40                  45              


Phe Pro Arg Lys Pro Tyr Glu Gly Arg Val Glu Ile Gln Arg Ala Gly 
    50                  55                  60                  


Glu Trp Gly Thr Ile Cys Asp Asp Asp Phe Thr Leu Gln Ala Ala His 
65                  70                  75                  80  


Ile Leu Cys Arg Glu Leu Gly Phe Thr Glu Ala Thr Gly Trp Thr His 
                85                  90                  95      


Ser Ala Lys Tyr Gly Pro Gly Thr Gly Arg Ile Trp Leu Asp Asn Leu 
            100                 105                 110         


Ser Cys Ser Gly Thr Glu Gln Ser Val Thr Glu Cys Ala Ser Arg Gly 
        115                 120                 125             


Trp Gly Asn Ser Asp Cys Thr His Asp Glu Asp Ala Gly Val Ile Cys 
    130                 135                 140                 


Lys Asp Gln Arg Leu Pro Gly Phe Ser Asp Ser Asn Val Ile Glu Val 
145                 150                 155                 160 


Glu His His Leu Gln Val Glu Glu Val Arg Ile Arg Pro Ala Val Gly 
                165                 170                 175     


Trp Gly Arg Arg Pro Leu Pro Val Thr Glu Gly Leu Val Glu Val Arg 
            180                 185                 190         


Leu Pro Asp Gly Trp Ser Gln Val Cys Asp Lys Gly Trp Ser Ala His 
        195                 200                 205             


Asn Ser His Val Val Cys Gly Met Leu Gly Phe Pro Ser Glu Lys Arg 
    210                 215                 220                 


Val Asn Ala Ala Phe Tyr Arg Leu Leu Ala Gln Arg Gln Gln His Ser 
225                 230                 235                 240 


Phe Gly Leu His Gly Val Ala Cys Val Gly Thr Glu Ala His Leu Ser 
                245                 250                 255     


Leu Cys Ser Leu Glu Phe Tyr Arg Ala Asn Asp Thr Ala Arg Cys Pro 
            260                 265                 270         


Gly Gly Gly Pro Ala Val Val Ser Cys Val Pro Gly Pro Val Tyr Ala 
        275                 280                 285             


Ala Ser Ser Gly Gln Lys Lys Gln Gln Gln Ser Lys Pro Gln Gly Glu 
    290                 295                 300                 


Ala Arg Val Arg Leu Lys Gly Gly Ala His Pro Gly Glu Gly Arg Val 
305                 310                 315                 320 


Glu Val Leu Lys Ala Ser Thr Trp Gly Thr Val Cys Asp Arg Lys Trp 
                325                 330                 335     


Asp Leu His Ala Ala Ser Val Val Cys Arg Glu Leu Gly Phe Gly Ser 
            340                 345                 350         


Ala Arg Glu Ala Leu Ser Gly Ala Arg Met Gly Gln Asp Val Ser Lys 
        355                 360                 365             


Arg Tyr Glu Cys Ala Asn Phe Gly Glu Gln Gly Ile Thr Val Gly Cys 
    370                 375                 380                 


Trp Asp Leu Tyr Arg His Asp Ile Asp Cys Gln Trp Ile Asp Ile Thr 
385                 390                 395                 400 


Asp Val Lys Pro Gly Asn Tyr Ile Leu Gln Val Val Ile Asn Pro Asn 
                405                 410                 415     


Phe Glu Val Ala Glu Ser Asp Phe Thr Asn Asn Ala Met Lys Cys Asn 
            420                 425                 430         


Cys Lys Tyr Asp Gly His Arg Ile Trp Val His Asn Cys His Ile Gly 
        435                 440                 445             


Asp Ala Phe Ser Glu Glu Ala Asn Arg Arg Phe Glu Arg Tyr Pro Gly 
    450                 455                 460                 


Gln Thr Ser Asn Gln Ile Ile 
465                 470     


<210>  7964
<211>  697
<212>  PRT
<213>  Homo Sapiens

<400>  7964

Met Arg Pro Val Ser Val Trp Gln Trp Ser Pro Trp Gly Leu Leu Leu 
1               5                   10                  15      


Cys Leu Leu Cys Ser Ser Cys Leu Gly Ser Pro Ser Pro Ser Thr Gly 
            20                  25                  30          


Pro Glu Lys Lys Ala Gly Ser Gln Gly Leu Arg Phe Arg Leu Ala Gly 
        35                  40                  45              


Phe Pro Arg Lys Pro Tyr Glu Gly Arg Val Glu Ile Gln Arg Ala Gly 
    50                  55                  60                  


Glu Trp Gly Thr Ile Cys Asp Asp Asp Phe Thr Leu Gln Ala Ala His 
65                  70                  75                  80  


Ile Leu Cys Arg Glu Leu Gly Phe Thr Glu Ala Thr Gly Trp Thr His 
                85                  90                  95      


Ser Ala Lys Tyr Gly Pro Gly Thr Gly Arg Ile Trp Leu Asp Asn Leu 
            100                 105                 110         


Ser Cys Ser Gly Thr Glu Gln Ser Val Thr Glu Cys Ala Ser Arg Gly 
        115                 120                 125             


Trp Gly Asn Ser Asp Cys Thr His Asp Glu Asp Ala Gly Val Ile Cys 
    130                 135                 140                 


Lys Asp Gln Arg Leu Pro Gly Phe Ser Asp Ser Asn Val Ile Glu Val 
145                 150                 155                 160 


Glu His His Leu Gln Val Glu Glu Val Arg Ile Arg Pro Ala Val Gly 
                165                 170                 175     


Trp Gly Arg Arg Pro Leu Pro Val Thr Glu Gly Leu Val Glu Val Arg 
            180                 185                 190         


Leu Pro Asp Gly Trp Ser Gln Val Cys Asp Lys Gly Trp Ser Ala His 
        195                 200                 205             


Asn Ser His Val Val Cys Gly Met Leu Gly Phe Pro Ser Glu Lys Arg 
    210                 215                 220                 


Val Asn Ala Ala Phe Tyr Arg Leu Leu Ala Gln Arg Gln Gln His Ser 
225                 230                 235                 240 


Phe Gly Leu His Gly Val Ala Cys Val Gly Thr Glu Ala His Leu Ser 
                245                 250                 255     


Leu Cys Ser Leu Glu Phe Tyr Arg Ala Asn Asp Thr Ala Arg Cys Pro 
            260                 265                 270         


Gly Gly Gly Pro Ala Val Val Ser Cys Val Pro Gly Pro Val Tyr Ala 
        275                 280                 285             


Ala Ser Ser Gly Gln Lys Lys Gln Gln Gln Ser Lys Pro Gln Gly Glu 
    290                 295                 300                 


Ala Arg Val Arg Leu Lys Gly Gly Ala His Pro Gly Glu Gly Arg Val 
305                 310                 315                 320 


Glu Val Leu Lys Ala Ser Thr Trp Gly Thr Val Cys Asp Arg Lys Trp 
                325                 330                 335     


Asp Leu His Ala Ala Ser Val Val Cys Arg Glu Leu Gly Phe Gly Ser 
            340                 345                 350         


Ala Arg Glu Ala Leu Ser Gly Ala Arg Met Gly Gln Gly Met Gly Ala 
        355                 360                 365             


Ile His Leu Ser Glu Val Arg Cys Ser Gly Gln Glu Leu Ser Leu Trp 
    370                 375                 380                 


Lys Cys Pro His Lys Asn Ile Thr Ala Glu Asp Cys Ser His Ser Gln 
385                 390                 395                 400 


Asp Ala Gly Val Arg Cys Asn Leu Pro Tyr Thr Gly Ala Glu Thr Arg 
                405                 410                 415     


Glu Thr Trp Tyr Trp Asp Ser Gly Asn Ile Thr Glu Val Val Met Ser 
            420                 425                 430         


Gly Val Arg Cys Thr Gly Thr Glu Leu Ser Leu Asp Gln Cys Ala His 
        435                 440                 445             


His Gly Thr His Ile Thr Cys Lys Arg Thr Gly Thr Arg Phe Thr Ala 
    450                 455                 460                 


Gly Val Ile Cys Ser Glu Thr Ala Ser Asp Leu Leu Leu His Ser Ala 
465                 470                 475                 480 


Leu Val Gln Glu Thr Ala Tyr Ile Glu Asp Arg Pro Leu His Met Leu 
                485                 490                 495     


Tyr Cys Ala Ala Glu Glu Asn Cys Leu Ala Ser Ser Ala Arg Ser Ala 
            500                 505                 510         


Asn Trp Pro Tyr Gly His Arg Arg Leu Leu Arg Phe Ser Ser Gln Ile 
        515                 520                 525             


His Asn Leu Gly Arg Ala Asp Phe Arg Pro Lys Ala Gly Arg His Ser 
    530                 535                 540                 


Trp Val Trp His Glu Cys His Gly His Tyr His Ser Met Asp Ile Phe 
545                 550                 555                 560 


Thr His Tyr Asp Ile Leu Thr Pro Asn Gly Thr Lys Val Ala Glu Gly 
                565                 570                 575     


His Lys Ala Ser Phe Cys Leu Glu Asp Thr Glu Cys Gln Glu Asp Val 
            580                 585                 590         


Ser Lys Arg Tyr Glu Cys Ala Asn Phe Gly Glu Gln Gly Ile Thr Val 
        595                 600                 605             


Gly Cys Trp Asp Leu Tyr Arg His Asp Ile Asp Cys Gln Trp Ile Asp 
    610                 615                 620                 


Ile Thr Asp Val Lys Pro Gly Asn Tyr Ile Leu Gln Val Val Ile Asn 
625                 630                 635                 640 


Pro Asn Phe Glu Val Ala Glu Ser Asp Phe Thr Asn Asn Ala Met Lys 
                645                 650                 655     


Cys Asn Cys Lys Tyr Asp Gly His Arg Ile Trp Val His Asn Cys His 
            660                 665                 670         


Ile Gly Asp Ala Phe Ser Glu Glu Ala Asn Arg Arg Phe Glu Arg Tyr 
        675                 680                 685             


Pro Gly Gln Thr Ser Asn Gln Ile Ile 
    690                 695         


<210>  7965
<211>  180
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  7965

Xaa Arg Gln Arg Leu Glu Arg Pro Gln Gln Pro Arg Gly Leu Arg Asp 
1               5                   10                  15      


Ala Gly Leu Pro Gln Arg Lys Glu Gly Gln Arg Gly Leu Leu Gln Ala 
            20                  25                  30          


Arg Val Arg Leu Lys Gly Gly Ala His Pro Gly Glu Gly Arg Val Glu 
        35                  40                  45              


Val Leu Lys Ala Ser Thr Trp Gly Thr Val Cys Asp Arg Lys Trp Asp 
    50                  55                  60                  


Leu His Ala Ala Ser Val Val Cys Arg Glu Leu Gly Phe Gly Ser Ala 
65                  70                  75                  80  


Arg Glu Ala Leu Ser Gly Ala Arg Met Gly Gln Gly Met Gly Ala Ile 
                85                  90                  95      


His Leu Ser Glu Val Arg Cys Ser Gly Gln Glu Leu Ser Leu Trp Lys 
            100                 105                 110         


Cys Pro His Lys Asn Ile Thr Ala Glu Asp Cys Ser His Ser Gln Asp 
        115                 120                 125             


Ala Gly Val Arg Cys Asn Leu Pro Tyr Thr Gly Ala Glu Thr Arg Ile 
    130                 135                 140                 


Arg Leu Ser Gly Gly Arg Ser Gln His Glu Gly Arg Val Glu Val Gln 
145                 150                 155                 160 


Ile Gly Gly Pro Gly Pro Leu Arg Trp Gly Leu Ile Cys Gly Asp Asp 
                165                 170                 175     


Trp Gly Thr Leu 
            180 


<210>  7966
<211>  756
<212>  PRT
<213>  Homo Sapiens

<400>  7966

Met Ala Trp Ser Pro Pro Ala Thr Leu Phe Leu Phe Leu Leu Leu Leu 
1               5                   10                  15      


Gly Gln Pro Pro Pro Ser Arg Pro Gln Ser Leu Gly Thr Thr Lys Leu 
            20                  25                  30          


Arg Leu Val Gly Pro Glu Ser Lys Pro Glu Glu Gly Arg Leu Glu Val 
        35                  40                  45              


Leu His Gln Gly Gln Trp Gly Thr Val Cys Asp Asp Asn Phe Ala Ile 
    50                  55                  60                  


Gln Glu Ala Thr Val Ala Cys Arg Gln Leu Gly Phe Glu Ala Ala Leu 
65                  70                  75                  80  


Thr Trp Ala His Ser Ala Lys Tyr Gly Gln Gly Glu Gly Pro Ile Trp 
                85                  90                  95      


Leu Asp Asn Val Arg Cys Val Gly Thr Glu Ser Ser Leu Asp Gln Cys 
            100                 105                 110         


Gly Ser Asn Gly Trp Gly Val Ser Asp Cys Ser His Ser Glu Asp Val 
        115                 120                 125             


Gly Val Ile Cys His Pro Arg Arg His Arg Gly Tyr Leu Ser Glu Thr 
    130                 135                 140                 


Val Ser Asn Ala Leu Gly Pro Gln Gly Arg Arg Leu Glu Glu Val Arg 
145                 150                 155                 160 


Leu Lys Pro Ile Leu Ala Ser Ala Lys Gln His Ser Pro Val Thr Glu 
                165                 170                 175     


Gly Ala Val Glu Val Lys Tyr Glu Gly His Trp Arg Gln Val Cys Asp 
            180                 185                 190         


Gln Gly Trp Thr Met Asn Asn Ser Arg Val Val Cys Gly Met Leu Gly 
        195                 200                 205             


Phe Pro Ser Glu Val Pro Val Asp Ser His Tyr Tyr Arg Lys Val Trp 
    210                 215                 220                 


Asp Leu Lys Met Arg Asp Pro Lys Ser Arg Leu Lys Ser Leu Thr Asn 
225                 230                 235                 240 


Lys Asn Ser Phe Trp Ile His Gln Val Thr Cys Leu Gly Thr Glu Pro 
                245                 250                 255     


His Met Ala Asn Cys Gln Val Gln Val Ala Pro Ala Arg Gly Lys Leu 
            260                 265                 270         


Arg Pro Ala Cys Pro Gly Gly Met His Ala Val Val Ser Cys Val Ala 
        275                 280                 285             


Gly Pro His Phe Arg Pro Pro Lys Thr Lys Pro Gln Arg Lys Gly Ser 
    290                 295                 300                 


Trp Ala Glu Glu Pro Arg Val Arg Leu Arg Ser Gly Ala Gln Val Gly 
305                 310                 315                 320 


Glu Gly Arg Val Glu Val Leu Met Asn Arg Gln Trp Gly Thr Val Cys 
                325                 330                 335     


Asp His Arg Trp Asn Leu Ile Ser Ala Ser Val Val Cys Arg Gln Leu 
            340                 345                 350         


Gly Phe Gly Ser Ala Arg Glu Ala Leu Phe Gly Ala Arg Leu Gly Gln 
        355                 360                 365             


Gly Leu Gly Pro Ile His Leu Ser Glu Val Arg Cys Arg Gly Tyr Glu 
    370                 375                 380                 


Arg Thr Leu Ser Asp Cys Pro Ala Leu Glu Gly Ser Gln Asn Gly Cys 
385                 390                 395                 400 


Gln His Glu Asn Asp Ala Ala Val Arg Cys Asn Val Pro Asn Met Gly 
                405                 410                 415     


Phe Gln Asn Gln Val Arg Leu Ala Gly Gly Arg Ile Pro Glu Glu Gly 
            420                 425                 430         


Leu Leu Glu Val Gln Val Glu Val Asn Gly Val Pro Arg Trp Gly Ser 
        435                 440                 445             


Val Cys Ser Glu Asn Trp Gly Leu Thr Glu Ala Met Val Ala Cys Arg 
    450                 455                 460                 


Gln Leu Gly Leu Gly Phe Ala Ile His Ala Tyr Lys Glu Thr Trp Phe 
465                 470                 475                 480 


Trp Ser Gly Thr Pro Arg Ala Gln Glu Val Val Met Ser Gly Val Arg 
                485                 490                 495     


Cys Ser Gly Thr Glu Leu Ala Leu Gln Gln Cys Gln Arg His Gly Pro 
            500                 505                 510         


Val His Cys Ser His Gly Gly Gly Arg Phe Leu Ala Gly Val Ser Cys 
        515                 520                 525             


Met Asp Ser Ala Pro Asp Leu Val Met Asn Ala Gln Leu Val Gln Glu 
    530                 535                 540                 


Thr Ala Tyr Leu Glu Asp Arg Pro Leu Ser Gln Leu Tyr Cys Ala His 
545                 550                 555                 560 


Glu Glu Asn Cys Leu Ser Lys Ser Ala Asp His Met Asp Trp Pro Tyr 
                565                 570                 575     


Gly Tyr Arg Arg Leu Leu Arg Phe Ser Thr Gln Ile Tyr Asn Leu Gly 
            580                 585                 590         


Arg Thr Asp Phe Arg Pro Lys Thr Gly Arg Asp Ser Trp Val Trp His 
        595                 600                 605             


Gln Cys His Arg His Tyr His Ser Ile Glu Val Phe Thr His Tyr Asp 
    610                 615                 620                 


Leu Leu Thr Leu Asn Gly Ser Lys Val Ala Glu Gly His Lys Ala Ser 
625                 630                 635                 640 


Phe Cys Leu Glu Asp Thr Asn Cys Pro Thr Gly Leu Gln Arg Arg Tyr 
                645                 650                 655     


Ala Cys Ala Asn Phe Gly Glu Gln Gly Val Thr Val Gly Cys Trp Asp 
            660                 665                 670         


Thr Tyr Arg His Asp Ile Asp Cys Gln Trp Val Asp Ile Thr Asp Val 
        675                 680                 685             


Gly Pro Gly Asn Tyr Ile Phe Gln Val Ile Val Asn Pro His Tyr Glu 
    690                 695                 700                 


Val Ala Glu Ser Asp Phe Ser Asn Asn Met Leu Gln Cys Arg Cys Lys 
705                 710                 715                 720 


Tyr Asp Gly His Arg Val Trp Leu His Asn Cys His Thr Gly Asn Ser 
                725                 730                 735     


Tyr Pro Ala Asn Ala Glu Leu Ser Leu Glu Gln Glu Gln Arg Leu Arg 
            740                 745                 750         


Asn Asn Leu Ile 
        755     


<210>  7967
<211>  2040
<212>  PRT
<213>  Homo Sapiens

<400>  7967

Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Ala Ala Pro Glu Gln Ser His Val Val Gln Asp Cys Tyr His Gly Asp 
            20                  25                  30          


Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr 
        35                  40                  45              


Cys Gln Ala Trp Ser Ser Met Thr Pro His Gln His Asn Arg Thr Thr 
    50                  55                  60                  


Glu Asn Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro 
65                  70                  75                  80  


Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg 
                85                  90                  95      


Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala 
            100                 105                 110         


Val Ala Pro Pro Thr Val Thr Pro Val Pro Ser Leu Glu Ala Pro Ser 
        115                 120                 125             


Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly Val Gln Glu Cys Tyr His 
    130                 135                 140                 


Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly 
145                 150                 155                 160 


Arg Thr Cys Gln Ala Trp Ser Ser Met Thr Pro His Ser His Ser Arg 
                165                 170                 175     


Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg 
            180                 185                 190         


Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly 
        195                 200                 205             


Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly 
    210                 215                 220                 


Thr Ala Val Ala Pro Pro Thr Val Thr Pro Val Pro Ser Leu Glu Ala 
225                 230                 235                 240 


Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly Val Gln Glu Cys 
                245                 250                 255     


Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val 
            260                 265                 270         


Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser Met Thr Pro His Ser His 
        275                 280                 285             


Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr 
    290                 295                 300                 


Cys Arg Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp 
305                 310                 315                 320 


Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala 
                325                 330                 335     


Glu Gly Thr Ala Val Ala Pro Pro Thr Val Thr Pro Val Pro Ser Leu 
            340                 345                 350         


Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly Val Gln 
        355                 360                 365             


Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr 
    370                 375                 380                 


Thr Val Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser Met Thr Pro His 
385                 390                 395                 400 


Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met 
                405                 410                 415     


Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr 
            420                 425                 430         


Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser 
        435                 440                 445             


Asp Ala Glu Gly Thr Ala Val Ala Pro Pro Thr Val Thr Pro Val Pro 
    450                 455                 460                 


Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly 
465                 470                 475                 480 


Val Gln Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr 
                485                 490                 495     


Ser Thr Thr Val Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser Met Thr 
            500                 505                 510         


Pro His Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu 
        515                 520                 525             


Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys 
    530                 535                 540                 


Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln 
545                 550                 555                 560 


Cys Ser Asp Ala Glu Gly Thr Ala Val Ala Pro Pro Thr Val Thr Pro 
                565                 570                 575     


Val Pro Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg 
            580                 585                 590         


Pro Gly Val Gln Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly 
        595                 600                 605             


Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser 
    610                 615                 620                 


Met Thr Pro His Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala 
625                 630                 635                 640 


Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala Ala Pro 
                645                 650                 655     


Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu 
            660                 665                 670         


Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala Val Ala Pro Pro Thr Val 
        675                 680                 685             


Thr Pro Val Pro Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu 
    690                 695                 700                 


Gln Arg Pro Gly Val Gln Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr 
705                 710                 715                 720 


Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr Cys Gln Ala Trp 
                725                 730                 735     


Ser Ser Met Thr Pro His Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro 
            740                 745                 750         


Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala 
        755                 760                 765             


Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys 
    770                 775                 780                 


Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala Val Ala Pro Pro 
785                 790                 795                 800 


Thr Val Thr Pro Val Pro Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro 
                805                 810                 815     


Thr Glu Gln Arg Pro Gly Val Gln Glu Cys Tyr His Gly Asn Gly Gln 
            820                 825                 830         


Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr Cys Gln 
        835                 840                 845             


Ala Trp Ser Ser Met Thr Pro His Ser His Ser Arg Thr Pro Glu Tyr 
    850                 855                 860                 


Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro Asp Pro 
865                 870                 875                 880 


Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Ser Val Arg Trp Glu 
                885                 890                 895     


Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala Val Ala 
            900                 905                 910         


Pro Pro Thr Ile Thr Pro Ile Pro Ser Leu Glu Ala Pro Ser Glu Gln 
        915                 920                 925             


Ala Pro Thr Glu Gln Arg Pro Gly Val Gln Glu Cys Tyr His Gly Asn 
    930                 935                 940                 


Gly Gln Ser Tyr Gln Gly Thr Tyr Phe Ile Thr Val Thr Gly Arg Thr 
945                 950                 955                 960 


Cys Gln Ala Trp Ser Ser Met Thr Pro His Ser His Ser Arg Thr Pro 
                965                 970                 975     


Ala Tyr Tyr Pro Asn Ala Gly Leu Ile Lys Asn Tyr Cys Arg Asn Pro 
            980                 985                 990         


Asp Pro Val Ala Ala Pro Trp Cys  Tyr Thr Thr Asp Pro  Ser Val Arg 
        995                 1000                 1005             


Trp Glu  Tyr Cys Asn Leu Thr  Arg Cys Ser Asp Ala  Glu Trp Thr 
    1010                 1015                 1020             


Ala Phe  Val Pro Pro Asn Val  Ile Leu Ala Pro Ser  Leu Glu Ala 
    1025                 1030                 1035             


Phe Phe  Glu Gln Ala Leu Thr  Glu Glu Thr Pro Gly  Val Gln Asp 
    1040                 1045                 1050             


Cys Tyr  Tyr His Tyr Gly Gln  Ser Tyr Arg Gly Thr  Tyr Ser Thr 
    1055                 1060                 1065             


Thr Val  Thr Gly Arg Thr Cys  Gln Ala Trp Ser Ser  Met Thr Pro 
    1070                 1075                 1080             


His Gln  His Ser Arg Thr Pro  Glu Asn Tyr Pro Asn  Ala Gly Leu 
    1085                 1090                 1095             


Thr Arg  Asn Tyr Cys Arg Asn  Pro Asp Ala Glu Ile  Arg Pro Trp 
    1100                 1105                 1110             


Cys Tyr  Thr Met Asp Pro Ser  Val Arg Trp Glu Tyr  Cys Asn Leu 
    1115                 1120                 1125             


Thr Gln  Cys Leu Val Thr Glu  Ser Ser Val Leu Ala  Thr Leu Thr 
    1130                 1135                 1140             


Val Val  Pro Asp Pro Ser Thr  Glu Ala Ser Ser Glu  Glu Ala Pro 
    1145                 1150                 1155             


Thr Glu  Gln Ser Pro Gly Val  Gln Asp Cys Tyr His  Gly Asp Gly 
    1160                 1165                 1170             


Gln Ser  Tyr Arg Gly Ser Phe  Ser Thr Thr Val Thr  Gly Arg Thr 
    1175                 1180                 1185             


Cys Gln  Ser Trp Ser Ser Met  Thr Pro His Trp His  Gln Arg Thr 
    1190                 1195                 1200             


Thr Glu  Tyr Tyr Pro Asn Gly  Gly Leu Thr Arg Asn  Tyr Cys Arg 
    1205                 1210                 1215             


Asn Pro  Asp Ala Glu Ile Ser  Pro Trp Cys Tyr Thr  Met Asp Pro 
    1220                 1225                 1230             


Asn Val  Arg Trp Glu Tyr Cys  Asn Leu Thr Gln Cys  Pro Val Thr 
    1235                 1240                 1245             


Glu Ser  Ser Val Leu Ala Thr  Ser Thr Ala Val Ser  Glu Gln Ala 
    1250                 1255                 1260             


Pro Thr  Glu Gln Ser Pro Thr  Val Gln Asp Cys Tyr  His Gly Asp 
    1265                 1270                 1275             


Gly Gln  Ser Tyr Arg Gly Ser  Phe Ser Thr Thr Val  Thr Gly Arg 
    1280                 1285                 1290             


Thr Cys  Gln Ser Trp Ser Ser  Met Thr Pro His Trp  His Gln Arg 
    1295                 1300                 1305             


Thr Thr  Glu Tyr Tyr Pro Asn  Gly Gly Leu Thr Arg  Asn Tyr Cys 
    1310                 1315                 1320             


Arg Asn  Pro Asp Ala Glu Ile  Arg Pro Trp Cys Tyr  Thr Met Asp 
    1325                 1330                 1335             


Pro Ser  Val Arg Trp Glu Tyr  Cys Asn Leu Thr Gln  Cys Pro Val 
    1340                 1345                 1350             


Met Glu  Ser Thr Leu Leu Thr  Thr Pro Thr Val Val  Pro Val Pro 
    1355                 1360                 1365             


Ser Thr  Glu Leu Pro Ser Glu  Glu Ala Pro Thr Glu  Asn Ser Thr 
    1370                 1375                 1380             


Gly Val  Gln Asp Cys Tyr Arg  Gly Asp Gly Gln Ser  Tyr Arg Gly 
    1385                 1390                 1395             


Thr Leu  Ser Thr Thr Ile Thr  Gly Arg Thr Cys Gln  Ser Trp Ser 
    1400                 1405                 1410             


Ser Met  Thr Pro His Trp His  Arg Arg Ile Pro Leu  Tyr Tyr Pro 
    1415                 1420                 1425             


Asn Ala  Gly Leu Thr Arg Asn  Tyr Cys Arg Asn Pro  Asp Ala Glu 
    1430                 1435                 1440             


Ile Arg  Pro Trp Cys Tyr Thr  Met Asp Pro Ser Val  Arg Trp Glu 
    1445                 1450                 1455             


Tyr Cys  Asn Leu Thr Arg Cys  Pro Val Thr Glu Ser  Ser Val Leu 
    1460                 1465                 1470             


Thr Thr  Pro Thr Val Ala Pro  Val Pro Ser Thr Glu  Ala Pro Ser 
    1475                 1480                 1485             


Glu Gln  Ala Pro Pro Glu Lys  Ser Pro Val Val Gln  Asp Cys Tyr 
    1490                 1495                 1500             


His Gly  Asp Gly Arg Ser Tyr  Arg Gly Ile Ser Ser  Thr Thr Val 
    1505                 1510                 1515             


Thr Gly  Arg Thr Cys Gln Ser  Trp Ser Ser Met Ile  Pro His Trp 
    1520                 1525                 1530             


His Gln  Arg Thr Pro Glu Asn  Tyr Pro Asn Ala Gly  Leu Thr Glu 
    1535                 1540                 1545             


Asn Tyr  Cys Arg Asn Pro Asp  Ser Gly Lys Gln Pro  Trp Cys Tyr 
    1550                 1555                 1560             


Thr Thr  Asp Pro Cys Val Arg  Trp Glu Tyr Cys Asn  Leu Thr Gln 
    1565                 1570                 1575             


Cys Ser  Glu Thr Glu Ser Gly  Val Leu Glu Thr Pro  Thr Val Val 
    1580                 1585                 1590             


Pro Val  Pro Ser Met Glu Ala  His Ser Glu Ala Ala  Pro Thr Glu 
    1595                 1600                 1605             


Gln Thr  Pro Val Val Arg Gln  Cys Tyr His Gly Asn  Gly Gln Ser 
    1610                 1615                 1620             


Tyr Arg  Gly Thr Phe Ser Thr  Thr Val Thr Gly Arg  Thr Cys Gln 
    1625                 1630                 1635             


Ser Trp  Ser Ser Met Thr Pro  His Arg His Gln Arg  Thr Pro Glu 
    1640                 1645                 1650             


Asn Tyr  Pro Asn Asp Gly Leu  Thr Met Asn Tyr Cys  Arg Asn Pro 
    1655                 1660                 1665             


Asp Ala  Asp Thr Gly Pro Trp  Cys Phe Thr Met Asp  Pro Ser Ile 
    1670                 1675                 1680             


Arg Trp  Glu Tyr Cys Asn Leu  Thr Arg Cys Ser Asp  Thr Glu Gly 
    1685                 1690                 1695             


Thr Val  Val Ala Pro Pro Thr  Val Ile Gln Val Pro  Ser Leu Gly 
    1700                 1705                 1710             


Pro Pro  Ser Glu Gln Asp Cys  Met Phe Gly Asn Gly  Lys Gly Tyr 
    1715                 1720                 1725             


Arg Gly  Lys Lys Ala Thr Thr  Val Thr Gly Thr Pro  Cys Gln Glu 
    1730                 1735                 1740             


Trp Ala  Ala Gln Glu Pro His  Arg His Ser Thr Phe  Ile Pro Gly 
    1745                 1750                 1755             


Thr Asn  Lys Trp Ala Gly Leu  Glu Lys Asn Tyr Cys  Arg Asn Pro 
    1760                 1765                 1770             


Asp Gly  Asp Ile Asn Gly Pro  Trp Cys Tyr Thr Met  Asn Pro Arg 
    1775                 1780                 1785             


Lys Leu  Phe Asp Tyr Cys Asp  Ile Pro Leu Cys Ala  Ser Ser Ser 
    1790                 1795                 1800             


Phe Asp  Cys Gly Lys Pro Gln  Val Glu Pro Lys Lys  Cys Pro Gly 
    1805                 1810                 1815             


Ser Ile  Val Gly Gly Cys Val  Ala His Pro His Ser  Trp Pro Trp 
    1820                 1825                 1830             


Gln Val  Ser Leu Arg Thr Arg  Phe Gly Lys His Phe  Cys Gly Gly 
    1835                 1840                 1845             


Thr Leu  Ile Ser Pro Glu Trp  Val Leu Thr Ala Ala  His Cys Leu 
    1850                 1855                 1860             


Lys Lys  Ser Ser Arg Pro Ser  Ser Tyr Lys Val Ile  Leu Gly Ala 
    1865                 1870                 1875             


His Gln  Glu Val Asn Leu Glu  Ser His Val Gln Glu  Ile Glu Val 
    1880                 1885                 1890             


Ser Arg  Leu Phe Leu Glu Pro  Thr Gln Ala Asp Ile  Ala Leu Leu 
    1895                 1900                 1905             


Lys Leu  Ser Arg Pro Ala Val  Ile Thr Asp Lys Val  Met Pro Ala 
    1910                 1915                 1920             


Cys Leu  Pro Ser Pro Asp Tyr  Met Val Thr Ala Arg  Thr Glu Cys 
    1925                 1930                 1935             


Tyr Ile  Thr Gly Trp Gly Glu  Thr Gln Gly Thr Phe  Gly Thr Gly 
    1940                 1945                 1950             


Leu Leu  Lys Glu Ala Gln Leu  Leu Val Ile Glu Asn  Glu Val Cys 
    1955                 1960                 1965             


Asn His  Tyr Lys Tyr Ile Cys  Ala Glu His Leu Ala  Arg Gly Thr 
    1970                 1975                 1980             


Asp Ser  Cys Gln Gly Asp Ser  Gly Gly Pro Leu Val  Cys Phe Glu 
    1985                 1990                 1995             


Lys Asp  Lys Tyr Ile Leu Gln  Gly Val Thr Ser Trp  Gly Leu Gly 
    2000                 2005                 2010             


Cys Ala  Arg Pro Asn Lys Pro  Gly Val Tyr Ala Arg  Val Ser Arg 
    2015                 2020                 2025             


Phe Val  Thr Trp Ile Glu Gly  Met Met Arg Asn Asn  
    2030                 2035                 2040 


<210>  7968
<211>  571
<212>  PRT
<213>  Homo Sapiens

<400>  7968

Ser Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala Ala 
1               5                   10                  15      


Pro Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys Asn 
            20                  25                  30          


Leu Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala Val Ala Pro Pro Thr 
        35                  40                  45              


Val Thr Pro Val Pro Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro Thr 
    50                  55                  60                  


Glu Gln Arg Pro Gly Val Gln Glu Cys Tyr His Gly Asn Gly Gln Ser 
65                  70                  75                  80  


Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr Cys Gln Ala 
                85                  90                  95      


Trp Ser Ser Met Thr Pro His Ser His Ser Arg Thr Pro Glu Tyr Tyr 
            100                 105                 110         


Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala Val 
        115                 120                 125             


Ala Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu Tyr 
    130                 135                 140                 


Cys Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala Val Ala Pro 
145                 150                 155                 160 


Pro Thr Val Thr Pro Val Pro Ser Leu Glu Ala Pro Ser Glu Gln Ala 
                165                 170                 175     


Pro Thr Glu Gln Arg Pro Gly Val Gln Glu Cys Tyr His Gly Asn Gly 
            180                 185                 190         


Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr Cys 
        195                 200                 205             


Gln Ala Trp Ser Ser Met Thr Pro His Ser His Ser Arg Thr Pro Glu 
    210                 215                 220                 


Tyr Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro Asp 
225                 230                 235                 240 


Ala Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg Trp 
                245                 250                 255     


Glu Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala Val 
            260                 265                 270         


Ala Pro Pro Thr Val Thr Pro Val Pro Ser Leu Glu Ala Pro Ser Glu 
        275                 280                 285             


Gln Ala Pro Thr Glu Gln Arg Pro Gly Val Gln Glu Cys Tyr His Gly 
    290                 295                 300                 


Asn Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg 
305                 310                 315                 320 


Thr Cys Gln Ala Trp Ser Ser Met Thr Pro His Ser His Ser Arg Thr 
                325                 330                 335     


Pro Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg Asn 
            340                 345                 350         


Pro Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly Val 
        355                 360                 365             


Arg Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly Thr 
    370                 375                 380                 


Ala Val Ala Pro Pro Thr Val Thr Pro Val Pro Ser Leu Glu Ala Pro 
385                 390                 395                 400 


Ser Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly Val Gln Glu Cys Tyr 
                405                 410                 415     


His Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr 
            420                 425                 430         


Gly Arg Thr Cys Gln Ala Trp Ser Ser Met Thr Pro His Ser His Ser 
        435                 440                 445             


Arg Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys 
    450                 455                 460                 


Arg Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp Pro 
465                 470                 475                 480 


Gly Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala Glu 
                485                 490                 495     


Gly Thr Ala Val Ala Pro Pro Thr Val Thr Pro Val Pro Ser Leu Glu 
            500                 505                 510         


Ala Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly Val Gln Glu 
        515                 520                 525             


Cys Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr 
    530                 535                 540                 


Val Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser Met Thr Pro His Ser 
545                 550                 555                 560 


His Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala 
                565                 570     


<210>  7969
<211>  613
<212>  PRT
<213>  Homo Sapiens

<400>  7969

Ser Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala Ala 
1               5                   10                  15      


Pro Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys Asn 
            20                  25                  30          


Leu Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala Val Ala Pro Pro Thr 
        35                  40                  45              


Val Thr Pro Val Pro Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro Thr 
    50                  55                  60                  


Glu Gln Arg Pro Gly Val Gln Glu Cys Tyr His Gly Asn Gly Gln Ser 
65                  70                  75                  80  


Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr Cys Gln Ala 
                85                  90                  95      


Trp Ser Ser Met Thr Pro His Ser His Ser Arg Thr Pro Glu Tyr Tyr 
            100                 105                 110         


Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro Asp Pro Val 
        115                 120                 125             


Ala Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Ser Val Arg Trp Glu Tyr 
    130                 135                 140                 


Cys Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala Val Ala Pro 
145                 150                 155                 160 


Pro Thr Ile Thr Pro Ile Pro Ser Leu Glu Ala Pro Ser Glu Gln Ala 
                165                 170                 175     


Pro Thr Glu Gln Arg Pro Gly Val Gln Glu Cys Tyr His Gly Asn Gly 
            180                 185                 190         


Gln Ser Tyr Gln Gly Thr Tyr Phe Ile Thr Val Thr Gly Arg Thr Cys 
        195                 200                 205             


Gln Ala Trp Ser Ser Met Thr Pro His Ser His Ser Arg Thr Pro Ala 
    210                 215                 220                 


Tyr Tyr Pro Asn Ala Gly Leu Ile Lys Asn Tyr Cys Arg Asn Pro Asp 
225                 230                 235                 240 


Pro Val Ala Ala Pro Trp Cys Tyr Thr Thr Asp Pro Ser Val Arg Trp 
                245                 250                 255     


Glu Tyr Cys Asn Leu Thr Arg Cys Ser Asp Ala Glu Trp Thr Ala Phe 
            260                 265                 270         


Val Pro Pro Asn Val Ile Leu Ala Pro Ser Leu Glu Ala Phe Phe Glu 
        275                 280                 285             


Gln Ala Leu Thr Glu Glu Thr Pro Gly Val Gln Asp Cys Tyr Tyr His 
    290                 295                 300                 


Tyr Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg 
305                 310                 315                 320 


Thr Cys Gln Ala Trp Ser Ser Met Thr Pro His Gln His Ser Arg Thr 
                325                 330                 335     


Pro Glu Asn Tyr Pro Asn Ala Gly Leu Thr Arg Asn Tyr Cys Arg Asn 
            340                 345                 350         


Pro Asp Ala Glu Ile Arg Pro Trp Cys Tyr Thr Met Asp Pro Ser Val 
        355                 360                 365             


Arg Trp Glu Tyr Cys Asn Leu Thr Gln Cys Leu Val Thr Glu Ser Ser 
    370                 375                 380                 


Val Leu Ala Thr Leu Thr Val Val Pro Asp Pro Ser Thr Glu Ala Ser 
385                 390                 395                 400 


Ser Glu Glu Ala Pro Thr Glu Gln Ser Pro Gly Val Gln Asp Cys Tyr 
                405                 410                 415     


His Gly Asp Gly Gln Ser Tyr Arg Gly Ser Phe Ser Thr Thr Val Thr 
            420                 425                 430         


Gly Arg Thr Cys Gln Ser Trp Ser Ser Met Thr Pro His Trp His Gln 
        435                 440                 445             


Arg Thr Thr Glu Tyr Tyr Pro Asn Gly Gly Leu Thr Arg Asn Tyr Cys 
    450                 455                 460                 


Arg Asn Pro Asp Ala Glu Ile Ser Pro Trp Cys Tyr Thr Met Asp Pro 
465                 470                 475                 480 


Asn Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln Cys Pro Val Thr Glu 
                485                 490                 495     


Ser Ser Val Leu Ala Thr Ser Thr Ala Val Ser Glu Gln Ala Pro Thr 
            500                 505                 510         


Glu Gln Ser Pro Thr Val Gln Asp Cys Tyr His Gly Asp Gly Gln Ser 
        515                 520                 525             


Tyr Arg Gly Ser Phe Ser Thr Thr Val Thr Gly Arg Thr Cys Gln Ser 
    530                 535                 540                 


Trp Ser Ser Met Thr Pro His Trp His Gln Arg Thr Thr Glu Tyr Tyr 
545                 550                 555                 560 


Pro Asn Gly Gly Leu Thr Arg Asn Tyr Cys Arg Asn Pro Asp Ala Glu 
                565                 570                 575     


Ile Arg Pro Trp Cys Tyr Thr Met Asp Pro Ser Val Arg Trp Glu Tyr 
            580                 585                 590         


Cys Asn Leu Thr Gln Cys Pro Val Met Glu Ser Thr Leu Leu Thr Thr 
        595                 600                 605             


Pro Thr Val Val Pro 
    610             


<210>  7970
<211>  39
<212>  PRT
<213>  Homo Sapiens

<400>  7970

Met Glu Ser Lys Ala Leu Leu Val Leu Thr Leu Ala Val Trp Leu Gln 
1               5                   10                  15      


Ser Leu Thr Ala Ser Arg Gly Gly Val Ala Ala Ala Asp Leu Ile Leu 
            20                  25                  30          


Lys Leu Gln Ile Phe Lys Phe 
        35                  


<210>  7971
<211>  106
<212>  PRT
<213>  Homo Sapiens

<400>  7971

Met Glu Ser Lys Ala Leu Leu Val Leu Thr Leu Ala Val Trp Leu Gln 
1               5                   10                  15      


Ser Leu Thr Ala Ser Arg Gly Gly Val Ala Ala Ala Asp Gln Arg Arg 
            20                  25                  30          


Asp Phe Ile Asp Ile Glu Ser Lys Phe Ala Leu Arg Thr Pro Glu Asp 
        35                  40                  45              


Thr Ala Glu Asp Thr Cys His Leu Ile Pro Gly Val Ala Glu Ser Val 
    50                  55                  60                  


Ala Thr Cys His Phe Asn His Ser Ser Lys Thr Phe Met Val Ile His 
65                  70                  75                  80  


Gly Trp Thr Val Thr Gly Met Tyr Glu Ser Trp Val Pro Lys Leu Val 
                85                  90                  95      


Ala Ala Leu Tyr Lys Arg Glu Pro Asp Ser 
            100                 105     


<210>  7972
<211>  130
<212>  PRT
<213>  Homo Sapiens

<400>  7972

Met Glu Ser Lys Ala Leu Leu Val Leu Thr Leu Ala Val Trp Leu Gln 
1               5                   10                  15      


Ser Leu Thr Ala Ser Arg Gly Gly Val Ala Ala Ala Asp Gln Arg Arg 
            20                  25                  30          


Asp Phe Ile Asp Ile Glu Ser Lys Phe Ala Leu Arg Thr Pro Glu Asp 
        35                  40                  45              


Thr Ala Glu Asp Thr Cys His Leu Ile Pro Gly Val Ala Glu Ser Val 
    50                  55                  60                  


Ala Thr Cys His Phe Asn His Ser Ser Lys Thr Phe Met Val Ile His 
65                  70                  75                  80  


Gly Trp Thr Val Thr Gly Met Tyr Glu Ser Trp Val Pro Lys Leu Val 
                85                  90                  95      


Ala Ala Leu Tyr Lys Arg Glu Pro Asp Ser Asn Val Ile Val Val Asp 
            100                 105                 110         


Trp Leu Ser Arg Ala Gln Glu His Tyr Pro Val Ser Ala Gly Tyr Thr 
        115                 120                 125             


Lys Leu 
    130 


<210>  7973
<211>  475
<212>  PRT
<213>  Homo Sapiens

<400>  7973

Met Glu Ser Lys Ala Leu Leu Val Leu Thr Leu Ala Val Trp Leu Gln 
1               5                   10                  15      


Ser Leu Thr Ala Ser Arg Gly Gly Val Ala Ala Ala Asp Gln Arg Arg 
            20                  25                  30          


Asp Phe Ile Asp Ile Glu Ser Lys Phe Ala Leu Arg Thr Pro Glu Asp 
        35                  40                  45              


Thr Ala Glu Asp Thr Cys His Leu Ile Pro Gly Val Ala Glu Ser Val 
    50                  55                  60                  


Ala Thr Cys His Phe Asn His Ser Ser Lys Thr Phe Met Val Ile His 
65                  70                  75                  80  


Gly Trp Thr Val Thr Gly Met Tyr Glu Ser Trp Val Pro Lys Leu Val 
                85                  90                  95      


Ala Ala Leu Tyr Lys Arg Glu Pro Asp Ser Asn Val Ile Val Val Asp 
            100                 105                 110         


Trp Leu Ser Arg Ala Gln Glu His Tyr Pro Val Ser Ala Gly Tyr Thr 
        115                 120                 125             


Lys Leu Val Gly Gln Asp Val Ala Arg Phe Ile Asn Trp Met Glu Glu 
    130                 135                 140                 


Glu Phe Asn Tyr Pro Leu Asp Asn Val His Leu Leu Gly Tyr Ser Leu 
145                 150                 155                 160 


Gly Ala His Ala Ala Gly Ile Ala Gly Ser Leu Thr Asn Lys Lys Val 
                165                 170                 175     


Asn Arg Ile Thr Gly Leu Asp Pro Ala Gly Pro Asn Phe Glu Tyr Ala 
            180                 185                 190         


Glu Ala Pro Ser Arg Leu Ser Pro Asp Asp Ala Asp Phe Val Asp Val 
        195                 200                 205             


Leu His Thr Phe Thr Arg Gly Ser Pro Gly Arg Ser Ile Gly Ile Gln 
    210                 215                 220                 


Lys Pro Val Gly His Val Asp Ile Tyr Pro Asn Gly Gly Thr Phe Gln 
225                 230                 235                 240 


Pro Gly Cys Asn Ile Gly Glu Ala Ile Arg Val Ile Ala Glu Arg Gly 
                245                 250                 255     


Leu Gly Asp Val Asp Gln Leu Val Lys Cys Ser His Glu Arg Ser Ile 
            260                 265                 270         


His Leu Phe Ile Asp Ser Leu Leu Asn Glu Glu Asn Pro Ser Lys Ala 
        275                 280                 285             


Tyr Arg Cys Ser Ser Lys Glu Ala Phe Glu Lys Gly Leu Cys Leu Ser 
    290                 295                 300                 


Cys Arg Lys Asn Arg Cys Asn Asn Leu Gly Tyr Glu Ile Asn Lys Val 
305                 310                 315                 320 


Arg Ala Lys Arg Ser Ser Lys Met Tyr Leu Lys Thr Arg Ser Gln Met 
                325                 330                 335     


Pro Tyr Lys Val Phe His Tyr Gln Val Lys Ile His Phe Ser Gly Thr 
            340                 345                 350         


Glu Ser Glu Thr His Thr Asn Gln Ala Phe Glu Ile Ser Leu Tyr Gly 
        355                 360                 365             


Thr Val Ala Glu Ser Glu Asn Ile Pro Phe Thr Leu Pro Glu Val Ser 
    370                 375                 380                 


Thr Asn Lys Thr Tyr Ser Phe Leu Ile Tyr Thr Glu Val Asp Ile Gly 
385                 390                 395                 400 


Glu Leu Leu Met Leu Lys Leu Lys Trp Lys Ser Asp Ser Tyr Phe Ser 
                405                 410                 415     


Trp Ser Asp Trp Trp Ser Ser Pro Gly Phe Ala Ile Gln Lys Ile Arg 
            420                 425                 430         


Val Lys Ala Gly Glu Thr Gln Lys Lys Val Ile Phe Cys Ser Arg Glu 
        435                 440                 445             


Lys Val Ser His Leu Gln Lys Gly Lys Ala Pro Ala Val Phe Val Lys 
    450                 455                 460                 


Cys His Asp Lys Ser Leu Asn Lys Lys Ser Gly 
465                 470                 475 


<210>  7974
<211>  115
<212>  PRT
<213>  Homo Sapiens

<400>  7974

Met Val Ile His Gly Trp Thr Val Thr Gly Met Tyr Glu Ser Trp Val 
1               5                   10                  15      


Pro Lys Leu Val Ala Ala Leu Tyr Lys Arg Glu Pro Asp Ser Asn Val 
            20                  25                  30          


Ile Val Val Asp Trp Leu Ser Arg Ala Gln Glu His Tyr Pro Val Ser 
        35                  40                  45              


Ala Gly Tyr Thr Lys Leu Val Gly Gln Asp Val Ala Arg Phe Ile Asn 
    50                  55                  60                  


Trp Met Glu Glu Glu Phe Asn Tyr Pro Leu Asp Asn Val His Leu Leu 
65                  70                  75                  80  


Gly Tyr Ser Leu Gly Ala His Ala Ala Gly Ile Ala Gly Ser Leu Thr 
                85                  90                  95      


Asn Lys Lys Val Asn Arg Ile Thr Gly Leu Asp Pro Ala Gly Pro Asn 
            100                 105                 110         


Phe Glu Tyr 
        115 


<210>  7975
<211>  117
<212>  PRT
<213>  Homo Sapiens

<400>  7975

Phe Pro Pro Asn Asp Pro Lys Ala Gly Thr Gln Gly Lys Cys Met Pro 
1               5                   10                  15      


Phe Phe Arg Ala Gly Phe Val Cys Pro Thr Pro Pro Tyr Lys Ser Leu 
            20                  25                  30          


Ala Arg Glu Gln Ile Asn Ala Leu Thr Ser Phe Leu Asp Ala Ser Phe 
        35                  40                  45              


Val Tyr Ser Ser Glu Pro Ser Leu Ala Ser Arg Leu Arg Asn Leu Ser 
    50                  55                  60                  


Ser Pro Leu Gly Leu Met Ala Val Asn Gln Glu Val Ser Asp His Gly 
65                  70                  75                  80  


Leu Pro Tyr Leu Pro Tyr Asp Ser Lys Lys Pro Ser Pro Cys Glu Phe 
                85                  90                  95      


Ile Asn Thr Thr Ala Arg Val Pro Cys Phe Leu Ala Gly Lys Glu Thr 
            100                 105                 110         


Glu Ala Gln Lys Cys 
        115         


<210>  7976
<211>  95
<212>  PRT
<213>  Homo Sapiens

<400>  7976

Gly Cys Gly Ala Pro Ala Pro Val Val Arg Cys Asp Pro Cys Ser Pro 
1               5                   10                  15      


Tyr Arg Thr Ile Thr Gly Asp Cys Asn Asn Arg Arg Lys Pro Ala Leu 
            20                  25                  30          


Gly Ala Ala Asn Arg Ala Leu Ala Arg Trp Leu Pro Ala Glu Tyr Glu 
        35                  40                  45              


Asp Gly Leu Ser Leu Pro Phe Gly Trp Thr Pro Gly Lys Thr Arg Asn 
    50                  55                  60                  


Gly Phe Pro Leu Pro Leu Ala Arg Glu Val Ser Asn Lys Ile Val Gly 
65                  70                  75                  80  


Tyr Leu Asn Glu Glu Gly Val Leu Asp Gln Asn Arg Ser Thr Leu 
                85                  90                  95  


<210>  7977
<211>  712
<212>  PRT
<213>  Homo Sapiens

<400>  7977

Met Arg Val Leu Leu His Leu Pro Ala Leu Leu Ala Ser Leu Ile Leu 
1               5                   10                  15      


Leu Gln Ala Ala Ala Ser Thr Thr Arg Ala Gln Thr Thr Arg Thr Ser 
            20                  25                  30          


Ala Ile Ser Asp Thr Val Ser Gln Ala Lys Val Gln Val Asn Lys Ala 
        35                  40                  45              


Phe Leu Asp Ser Arg Thr Arg Leu Lys Thr Ala Met Ser Ser Glu Thr 
    50                  55                  60                  


Pro Thr Ser Arg Gln Leu Ser Glu Tyr Leu Lys His Ala Lys Gly Arg 
65                  70                  75                  80  


Thr Arg Thr Ala Ile Arg Asn Gly Gln Val Trp Glu Glu Ser Leu Lys 
                85                  90                  95      


Arg Leu Arg Gln Lys Ala Ser Leu Thr Asn Val Thr Asp Pro Ser Leu 
            100                 105                 110         


Asp Leu Thr Ser Leu Ser Leu Glu Val Gly Cys Gly Ala Pro Ala Pro 
        115                 120                 125             


Val Val Arg Cys Asp Pro Cys Ser Pro Tyr Arg Thr Ile Thr Gly Asp 
    130                 135                 140                 


Cys Asn Asn Arg Arg Lys Pro Ala Leu Gly Ala Ala Asn Arg Ala Leu 
145                 150                 155                 160 


Ala Arg Trp Leu Pro Ala Glu Tyr Glu Asp Gly Leu Ser Leu Pro Phe 
                165                 170                 175     


Gly Trp Thr Pro Gly Lys Thr Arg Asn Gly Phe Pro Leu Pro Leu Ala 
            180                 185                 190         


Arg Glu Val Ser Asn Lys Ile Val Gly Tyr Leu Asn Glu Glu Gly Val 
        195                 200                 205             


Leu Asp Gln Asn Arg Ser Leu Leu Phe Met Gln Trp Gly Gln Ile Val 
    210                 215                 220                 


Asp His Asp Leu Asp Phe Ala Pro Asp Thr Glu Leu Gly Ser Ser Glu 
225                 230                 235                 240 


Tyr Ser Lys Ala Gln Cys Asp Glu Tyr Cys Ile Gln Gly Asp Asn Cys 
                245                 250                 255     


Phe Pro Ile Met Phe Pro Pro Asn Asp Pro Lys Ala Gly Thr Gln Gly 
            260                 265                 270         


Lys Cys Met Pro Phe Phe Arg Ala Gly Phe Val Cys Pro Thr Pro Pro 
        275                 280                 285             


Tyr Lys Ser Leu Ala Arg Glu Gln Ile Asn Ala Leu Thr Ser Phe Leu 
    290                 295                 300                 


Asp Ala Ser Phe Val Tyr Ser Ser Glu Pro Ser Leu Ala Ser Arg Leu 
305                 310                 315                 320 


Arg Asn Leu Ser Ser Pro Leu Gly Leu Met Ala Val Asn Gln Glu Val 
                325                 330                 335     


Ser Asp His Gly Leu Pro Tyr Leu Pro Tyr Asp Ser Lys Lys Pro Ser 
            340                 345                 350         


Pro Cys Glu Phe Ile Asn Thr Thr Ala Arg Val Pro Cys Phe Leu Ala 
        355                 360                 365             


Gly Asp Ser Arg Ala Ser Glu His Ile Leu Leu Ala Thr Ser His Thr 
    370                 375                 380                 


Leu Phe Leu Arg Glu His Asn Arg Leu Ala Arg Glu Leu Lys Arg Leu 
385                 390                 395                 400 


Asn Pro Gln Trp Asp Gly Glu Lys Leu Tyr Gln Glu Ala Arg Lys Ile 
                405                 410                 415     


Leu Gly Ala Phe Val Gln Ile Ile Thr Phe Arg Asp Tyr Leu Pro Ile 
            420                 425                 430         


Leu Leu Gly Asp His Met Gln Lys Trp Ile Pro Pro Tyr Gln Gly Tyr 
        435                 440                 445             


Ser Glu Ser Val Asp Pro Arg Ile Ser Asn Val Phe Thr Phe Ala Phe 
    450                 455                 460                 


Arg Phe Gly His Leu Glu Val Pro Ser Ser Met Phe Arg Leu Asp Glu 
465                 470                 475                 480 


Asn Tyr Gln Pro Trp Gly Pro Glu Pro Glu Leu Pro Leu His Thr Leu 
                485                 490                 495     


Phe Phe Asn Thr Trp Arg Met Val Lys Asp Gly Gly Ile Asp Pro Leu 
            500                 505                 510         


Val Arg Gly Leu Leu Ala Lys Lys Ser Lys Leu Met Lys Gln Asn Lys 
        515                 520                 525             


Met Met Thr Gly Glu Leu Arg Asn Lys Leu Phe Gln Pro Thr His Arg 
    530                 535                 540                 


Ile His Gly Phe Asp Leu Ala Ala Ile Asn Thr Gln Arg Cys Arg Asp 
545                 550                 555                 560 


His Gly Gln Pro Gly Tyr Asn Ser Trp Arg Ala Phe Cys Asp Leu Ser 
                565                 570                 575     


Gln Pro Gln Thr Leu Glu Glu Leu Asn Thr Val Leu Lys Ser Lys Met 
            580                 585                 590         


Leu Ala Lys Lys Leu Leu Gly Leu Tyr Gly Thr Pro Asp Asn Ile Asp 
        595                 600                 605             


Ile Trp Ile Gly Ala Ile Ala Glu Pro Leu Val Glu Arg Gly Arg Val 
    610                 615                 620                 


Gly Pro Leu Leu Ala Cys Leu Leu Gly Lys Gln Phe Gln Gln Ile Arg 
625                 630                 635                 640 


Asp Gly Asp Arg Phe Trp Trp Glu Asn Pro Gly Val Phe Thr Asn Glu 
                645                 650                 655     


Gln Lys Asp Ser Leu Gln Lys Met Ser Phe Ser Arg Leu Val Cys Asp 
            660                 665                 670         


Asn Thr Arg Ile Thr Lys Val Pro Arg Asp Pro Phe Trp Ala Asn Ser 
        675                 680                 685             


Tyr Pro Tyr Asp Phe Val Asp Cys Ser Ala Ile Asp Lys Leu Asp Leu 
    690                 695                 700                 


Ser Pro Trp Ala Ser Val Lys Asn 
705                 710         


<210>  7978
<211>  629
<212>  PRT
<213>  Homo Sapiens

<400>  7978

Met Arg Val Leu Leu His Leu Pro Ala Leu Leu Ala Ser Leu Ile Leu 
1               5                   10                  15      


Leu Gln Ala Ala Ala Ser Thr Thr Arg Asp Pro Ser Leu Asp Leu Thr 
            20                  25                  30          


Ser Leu Ser Leu Glu Val Gly Cys Gly Ala Pro Ala Pro Val Val Arg 
        35                  40                  45              


Cys Asp Pro Cys Ser Pro Tyr Arg Thr Ile Thr Gly Asp Cys Asn Asn 
    50                  55                  60                  


Arg Arg Lys Pro Ala Leu Gly Ala Ala Asn Arg Ala Leu Ala Arg Trp 
65                  70                  75                  80  


Leu Pro Ala Glu Tyr Glu Asp Gly Leu Ser Leu Pro Phe Gly Trp Thr 
                85                  90                  95      


Pro Gly Lys Thr Arg Asn Gly Phe Pro Leu Pro Leu Ala Arg Glu Val 
            100                 105                 110         


Ser Asn Lys Ile Val Gly Tyr Leu Asn Glu Glu Gly Val Leu Asp Gln 
        115                 120                 125             


Asn Arg Ser Leu Leu Phe Met Gln Trp Gly Gln Ile Val Asp His Asp 
    130                 135                 140                 


Leu Asp Phe Ala Pro Asp Thr Glu Leu Gly Ser Ser Glu Tyr Ser Lys 
145                 150                 155                 160 


Ala Gln Cys Asp Glu Tyr Cys Ile Gln Gly Asp Asn Cys Phe Pro Ile 
                165                 170                 175     


Met Phe Pro Pro Asn Asp Pro Lys Ala Gly Thr Gln Gly Lys Cys Met 
            180                 185                 190         


Pro Phe Phe Arg Ala Gly Phe Val Cys Pro Thr Pro Pro Tyr Lys Ser 
        195                 200                 205             


Leu Ala Arg Glu Gln Ile Asn Ala Leu Thr Ser Phe Leu Asp Ala Ser 
    210                 215                 220                 


Phe Val Tyr Ser Ser Glu Pro Ser Leu Ala Ser Arg Leu Arg Asn Leu 
225                 230                 235                 240 


Ser Ser Pro Leu Gly Leu Met Ala Val Asn Gln Glu Val Ser Asp His 
                245                 250                 255     


Gly Leu Pro Tyr Leu Pro Tyr Asp Ser Lys Lys Pro Ser Pro Cys Glu 
            260                 265                 270         


Phe Ile Asn Thr Thr Ala Arg Val Pro Cys Phe Leu Ala Gly Asp Ser 
        275                 280                 285             


Arg Ala Ser Glu His Ile Leu Leu Ala Thr Ser His Thr Leu Phe Leu 
    290                 295                 300                 


Arg Glu His Asn Arg Leu Ala Arg Glu Leu Lys Arg Leu Asn Pro Gln 
305                 310                 315                 320 


Trp Asp Gly Glu Lys Leu Tyr Gln Glu Ala Arg Lys Ile Leu Gly Ala 
                325                 330                 335     


Phe Val Gln Ile Ile Thr Phe Arg Asp Tyr Leu Pro Ile Leu Leu Gly 
            340                 345                 350         


Asp His Met Gln Lys Trp Ile Pro Pro Tyr Gln Gly Tyr Ser Glu Ser 
        355                 360                 365             


Val Asp Pro Arg Ile Ser Asn Val Phe Thr Phe Ala Phe Arg Phe Gly 
    370                 375                 380                 


His Leu Glu Val Pro Ser Ser Met Phe Arg Leu Asp Glu Asn Tyr Gln 
385                 390                 395                 400 


Pro Trp Gly Pro Glu Pro Glu Leu Pro Leu His Thr Leu Phe Phe Asn 
                405                 410                 415     


Thr Trp Arg Met Val Lys Asp Gly Gly Ile Asp Pro Leu Val Arg Gly 
            420                 425                 430         


Leu Leu Ala Lys Lys Ser Lys Leu Met Lys Gln Asn Lys Met Met Thr 
        435                 440                 445             


Gly Glu Leu Arg Asn Lys Leu Phe Gln Pro Thr His Arg Ile His Gly 
    450                 455                 460                 


Phe Asp Leu Ala Ala Ile Asn Thr Gln Arg Cys Arg Asp His Gly Gln 
465                 470                 475                 480 


Pro Gly Tyr Asn Ser Trp Arg Ala Phe Cys Asp Leu Ser Gln Pro Gln 
                485                 490                 495     


Thr Leu Glu Glu Leu Asn Thr Val Leu Lys Ser Lys Met Leu Ala Lys 
            500                 505                 510         


Lys Leu Leu Gly Leu Tyr Gly Thr Pro Asp Asn Ile Asp Ile Trp Ile 
        515                 520                 525             


Gly Ala Ile Ala Glu Pro Leu Val Glu Arg Gly Arg Val Gly Pro Leu 
    530                 535                 540                 


Leu Ala Cys Leu Leu Gly Lys Gln Phe Gln Gln Ile Arg Asp Gly Asp 
545                 550                 555                 560 


Arg Phe Trp Trp Glu Asn Pro Gly Val Phe Thr Asn Glu Gln Lys Asp 
                565                 570                 575     


Ser Leu Gln Lys Met Ser Phe Ser Arg Leu Val Cys Asp Asn Thr Arg 
            580                 585                 590         


Ile Thr Lys Val Pro Arg Asp Pro Phe Trp Ala Asn Ser Tyr Pro Tyr 
        595                 600                 605             


Asp Phe Val Asp Cys Ser Ala Ile Asp Lys Leu Asp Leu Ser Pro Trp 
    610                 615                 620                 


Ala Ser Val Lys Asn 
625                 


<210>  7979
<211>  629
<212>  PRT
<213>  Homo Sapiens

<400>  7979

Met Arg Val Leu Leu His Leu Pro Ala Leu Leu Ala Ser Leu Ile Leu 
1               5                   10                  15      


Leu Gln Ala Ala Ala Ser Thr Thr Arg Asp Pro Ser Leu Asp Leu Thr 
            20                  25                  30          


Ser Leu Ser Leu Glu Val Gly Cys Gly Ala Pro Ala Pro Val Val Arg 
        35                  40                  45              


Cys Asp Pro Cys Ser Pro Tyr Arg Thr Ile Thr Gly Asp Cys Asn Asn 
    50                  55                  60                  


Arg Arg Lys Pro Ala Leu Gly Ala Ala Asn Arg Ala Leu Ala Arg Trp 
65                  70                  75                  80  


Leu Pro Ala Glu Tyr Glu Asp Gly Leu Ser Leu Pro Phe Gly Trp Thr 
                85                  90                  95      


Pro Gly Lys Thr Arg Asn Gly Phe Pro Leu Pro Leu Ala Arg Glu Val 
            100                 105                 110         


Ser Asn Lys Ile Val Gly Tyr Leu Asn Glu Glu Gly Val Leu Asp Gln 
        115                 120                 125             


Asn Arg Ser Leu Leu Phe Met Gln Trp Gly Gln Ile Val Asp His Asp 
    130                 135                 140                 


Leu Asp Phe Ala Pro Asp Thr Glu Leu Gly Ser Ser Glu Tyr Ser Lys 
145                 150                 155                 160 


Ala Gln Cys Asp Glu Tyr Cys Ile Gln Gly Asp Asn Cys Phe Pro Ile 
                165                 170                 175     


Met Phe Pro Pro Asn Asp Pro Lys Ala Gly Thr Gln Gly Lys Cys Met 
            180                 185                 190         


Pro Phe Phe Arg Ala Gly Phe Val Cys Pro Thr Pro Pro Tyr Lys Ser 
        195                 200                 205             


Leu Ala Arg Glu Gln Ile Asn Ala Leu Thr Ser Phe Leu Asp Ala Ser 
    210                 215                 220                 


Phe Val Tyr Ser Ser Glu Pro Ser Leu Ala Ser Arg Leu Arg Asn Leu 
225                 230                 235                 240 


Ser Ser Pro Leu Gly Leu Met Ala Val Asn Gln Glu Val Ser Asp His 
                245                 250                 255     


Gly Leu Pro Tyr Leu Pro Tyr Asp Ser Lys Lys Pro Ser Pro Cys Glu 
            260                 265                 270         


Phe Ile Asn Thr Thr Ala Arg Val Pro Cys Phe Leu Ala Gly Asp Ser 
        275                 280                 285             


Arg Ala Ser Glu His Ile Leu Leu Ala Thr Ser His Thr Leu Phe Leu 
    290                 295                 300                 


Arg Glu His Asn Arg Leu Ala Arg Glu Leu Lys Arg Leu Asn Pro Gln 
305                 310                 315                 320 


Trp Asp Gly Glu Lys Leu Tyr Gln Glu Ala Arg Lys Ile Leu Gly Ala 
                325                 330                 335     


Phe Val Gln Ile Ile Thr Phe Arg Asp Tyr Leu Pro Ile Leu Leu Gly 
            340                 345                 350         


Asp His Met Gln Lys Trp Ile Pro Pro Tyr Gln Gly Tyr Ser Glu Ser 
        355                 360                 365             


Val Asp Pro Arg Ile Ser Asn Val Phe Thr Phe Ala Phe Arg Phe Gly 
    370                 375                 380                 


His Leu Glu Val Pro Ser Ser Met Phe Arg Leu Asp Glu Asn Tyr Gln 
385                 390                 395                 400 


Pro Trp Gly Pro Glu Pro Glu Leu Pro Leu His Thr Leu Phe Phe Asn 
                405                 410                 415     


Thr Trp Arg Met Val Lys Asp Gly Gly Ile Asp Pro Leu Val Arg Gly 
            420                 425                 430         


Leu Leu Ala Lys Lys Ser Lys Leu Met Lys Gln Asn Lys Met Met Thr 
        435                 440                 445             


Gly Glu Leu Arg Asn Lys Leu Phe Gln Pro Thr His Arg Ile His Gly 
    450                 455                 460                 


Phe Asp Leu Ala Ala Ile Asn Thr Gln Arg Cys Arg Asp His Gly Gln 
465                 470                 475                 480 


Pro Gly Tyr Asn Ser Trp Arg Ala Phe Cys Asp Leu Ser Gln Pro Gln 
                485                 490                 495     


Thr Leu Glu Glu Leu Asn Thr Val Leu Lys Ser Lys Met Leu Ala Lys 
            500                 505                 510         


Lys Leu Leu Gly Leu Tyr Gly Thr Pro Asp Asn Ile Asp Ile Trp Ile 
        515                 520                 525             


Gly Ala Ile Ala Glu Pro Leu Val Glu Arg Gly Arg Val Gly Pro Leu 
    530                 535                 540                 


Leu Ala Cys Leu Leu Gly Lys Gln Phe Gln Gln Ile Arg Asp Gly Asp 
545                 550                 555                 560 


Arg Phe Trp Trp Glu Asn Pro Gly Val Phe Thr Asn Glu Gln Lys Asp 
                565                 570                 575     


Ser Leu Gln Lys Met Ser Phe Ser Arg Leu Val Cys Asp Asn Thr Arg 
            580                 585                 590         


Ile Thr Lys Val Pro Arg Asp Pro Phe Trp Ala Asn Ser Tyr Pro Tyr 
        595                 600                 605             


Asp Phe Val Asp Cys Ser Ala Ile Asp Lys Leu Asp Leu Ser Pro Trp 
    610                 615                 620                 


Ala Ser Val Lys Asn 
625                 


<210>  7980
<211>  123
<212>  PRT
<213>  Homo Sapiens

<400>  7980

Met Ser Ser Glu Thr Pro Thr Ser Arg Gln Leu Ser Glu Tyr Leu Lys 
1               5                   10                  15      


His Ala Lys Gly Arg Thr Arg Thr Ala Ile Arg Asn Gly Gln Val Trp 
            20                  25                  30          


Glu Glu Ser Leu Lys Arg Leu Arg Gln Lys Ala Ser Leu Thr Asn Val 
        35                  40                  45              


Thr Asp Pro Ser Leu Asp Leu Thr Ser Leu Ser Leu Glu Val Gly Cys 
    50                  55                  60                  


Gly Ala Pro Ala Pro Val Val Arg Cys Asp Pro Cys Ser Pro Tyr Arg 
65                  70                  75                  80  


Thr Ile Thr Gly Asp Cys Asn Asn Arg Arg Lys Pro Ala Leu Gly Ala 
                85                  90                  95      


Ala Asn Arg Ala Leu Ala Arg Trp Leu Pro Ala Glu Tyr Glu Asp Gly 
            100                 105                 110         


Leu Ser Leu Pro Phe Gly Trp Thr Pro Gly Lys 
        115                 120             


<210>  7981
<211>  653
<212>  PRT
<213>  Homo Sapiens

<400>  7981

Met Ser Ser Glu Thr Pro Thr Ser Arg Gln Leu Ser Glu Tyr Leu Lys 
1               5                   10                  15      


His Ala Lys Gly Arg Thr Arg Thr Ala Ile Arg Asn Gly Gln Val Trp 
            20                  25                  30          


Glu Glu Ser Leu Lys Arg Leu Arg Gln Lys Ala Ser Leu Thr Asn Val 
        35                  40                  45              


Thr Asp Pro Ser Leu Asp Leu Thr Ser Leu Ser Leu Glu Val Gly Cys 
    50                  55                  60                  


Gly Ala Pro Ala Pro Val Val Arg Cys Asp Pro Cys Ser Pro Tyr Arg 
65                  70                  75                  80  


Thr Ile Thr Gly Asp Cys Asn Asn Arg Arg Lys Pro Ala Leu Gly Ala 
                85                  90                  95      


Ala Asn Arg Ala Leu Ala Arg Trp Leu Pro Ala Glu Tyr Glu Asp Gly 
            100                 105                 110         


Leu Ser Leu Pro Phe Gly Trp Thr Pro Gly Lys Thr Arg Asn Gly Phe 
        115                 120                 125             


Pro Leu Pro Leu Ala Arg Glu Val Ser Asn Lys Ile Val Gly Tyr Leu 
    130                 135                 140                 


Asn Glu Glu Gly Val Leu Asp Gln Asn Arg Ser Leu Leu Phe Met Gln 
145                 150                 155                 160 


Trp Gly Gln Ile Val Asp His Asp Leu Asp Phe Ala Pro Asp Thr Glu 
                165                 170                 175     


Leu Gly Ser Ser Glu Tyr Ser Lys Ala Gln Cys Asp Glu Tyr Cys Ile 
            180                 185                 190         


Gln Gly Asp Asn Cys Phe Pro Ile Met Phe Pro Pro Asn Asp Pro Lys 
        195                 200                 205             


Ala Gly Thr Gln Gly Lys Cys Met Pro Phe Phe Arg Ala Gly Phe Val 
    210                 215                 220                 


Cys Pro Thr Pro Pro Tyr Lys Ser Leu Ala Arg Glu Gln Ile Asn Ala 
225                 230                 235                 240 


Leu Thr Ser Phe Leu Asp Ala Ser Phe Val Tyr Ser Ser Glu Pro Ser 
                245                 250                 255     


Leu Ala Ser Arg Leu Arg Asn Leu Ser Ser Pro Leu Gly Leu Met Ala 
            260                 265                 270         


Val Asn Gln Glu Val Ser Asp His Gly Leu Pro Tyr Leu Pro Tyr Asp 
        275                 280                 285             


Ser Lys Lys Pro Ser Pro Cys Glu Phe Ile Asn Thr Thr Ala Arg Val 
    290                 295                 300                 


Pro Cys Phe Leu Ala Gly Asp Ser Arg Ala Ser Glu His Ile Leu Leu 
305                 310                 315                 320 


Ala Thr Ser His Thr Leu Phe Leu Arg Glu His Asn Arg Leu Ala Arg 
                325                 330                 335     


Glu Leu Lys Arg Leu Asn Pro Gln Trp Asp Gly Glu Lys Leu Tyr Gln 
            340                 345                 350         


Glu Ala Arg Lys Ile Leu Gly Ala Phe Val Gln Ile Ile Thr Phe Arg 
        355                 360                 365             


Asp Tyr Leu Pro Ile Leu Leu Gly Asp His Met Gln Lys Trp Ile Pro 
    370                 375                 380                 


Pro Tyr Gln Gly Tyr Ser Glu Ser Val Asp Pro Arg Ile Ser Asn Val 
385                 390                 395                 400 


Phe Thr Phe Ala Phe Arg Phe Gly His Leu Glu Val Pro Ser Ser Met 
                405                 410                 415     


Phe Arg Leu Asp Glu Asn Tyr Gln Pro Trp Gly Pro Glu Pro Glu Leu 
            420                 425                 430         


Pro Leu His Thr Leu Phe Phe Asn Thr Trp Arg Met Val Lys Asp Gly 
        435                 440                 445             


Gly Ile Asp Pro Leu Val Arg Gly Leu Leu Ala Lys Lys Ser Lys Leu 
    450                 455                 460                 


Met Lys Gln Asn Lys Met Met Thr Gly Glu Leu Arg Asn Lys Leu Phe 
465                 470                 475                 480 


Gln Pro Thr His Arg Ile His Gly Phe Asp Leu Ala Ala Ile Asn Thr 
                485                 490                 495     


Gln Arg Cys Arg Asp His Gly Gln Pro Gly Tyr Asn Ser Trp Arg Ala 
            500                 505                 510         


Phe Cys Asp Leu Ser Gln Pro Gln Thr Leu Glu Glu Leu Asn Thr Val 
        515                 520                 525             


Leu Lys Ser Lys Met Leu Ala Lys Lys Leu Leu Gly Leu Tyr Gly Thr 
    530                 535                 540                 


Pro Asp Asn Ile Asp Ile Trp Ile Gly Ala Ile Ala Glu Pro Leu Val 
545                 550                 555                 560 


Glu Arg Gly Arg Val Gly Pro Leu Leu Ala Cys Leu Leu Gly Lys Gln 
                565                 570                 575     


Phe Gln Gln Ile Arg Asp Gly Asp Arg Phe Trp Trp Glu Asn Pro Gly 
            580                 585                 590         


Val Phe Thr Asn Glu Gln Lys Asp Ser Leu Gln Lys Met Ser Phe Ser 
        595                 600                 605             


Arg Leu Val Cys Asp Asn Thr Arg Ile Thr Lys Val Pro Arg Asp Pro 
    610                 615                 620                 


Phe Trp Ala Asn Ser Tyr Pro Tyr Asp Phe Val Asp Cys Ser Ala Ile 
625                 630                 635                 640 


Asp Lys Leu Asp Leu Ser Pro Trp Ala Ser Val Lys Asn 
                645                 650             


<210>  7982
<211>  69
<212>  PRT
<213>  Homo Sapiens

<400>  7982

Met Lys Asn Pro Met Leu Glu Val Val Ser Leu Leu Leu Glu Lys Leu 
1               5                   10                  15      


Leu Leu Ile Ser Asn Phe Thr Leu Phe Ser Ser Gly Ala Ala Gly Glu 
            20                  25                  30          


Asp Lys Gly Arg Asn Ser Phe Tyr Glu Thr Ser Ser Phe His Arg Gly 
        35                  40                  45              


Asp Val Leu Glu Val Pro Arg Thr His Leu Thr His Tyr Gly Ile Tyr 
    50                  55                  60                  


Leu Gly Asp Asn Arg 
65                  


<210>  7983
<211>  230
<212>  PRT
<213>  Homo Sapiens

<400>  7983

Met Lys Asn Pro Met Leu Glu Val Val Ser Leu Leu Leu Glu Lys Leu 
1               5                   10                  15      


Leu Leu Ile Ser Asn Phe Thr Leu Phe Ser Ser Gly Ala Ala Gly Glu 
            20                  25                  30          


Asp Lys Gly Arg Asn Ser Phe Tyr Glu Thr Ser Ser Phe His Arg Gly 
        35                  40                  45              


Asp Val Leu Glu Val Pro Arg Thr His Leu Thr His Tyr Gly Ile Tyr 
    50                  55                  60                  


Leu Gly Asp Asn Arg Val Ala His Met Met Pro Asp Ile Leu Leu Ala 
65                  70                  75                  80  


Leu Thr Asp Asp Met Gly Arg Thr Gln Lys Val Val Ser Asn Lys Arg 
                85                  90                  95      


Leu Ile Leu Gly Val Ile Val Lys Val Ala Ser Ile Arg Val Asp Thr 
            100                 105                 110         


Val Glu Asp Phe Ala Tyr Gly Ala Asn Ile Leu Val Asn His Leu Asp 
        115                 120                 125             


Glu Ser Leu Gln Lys Lys Ala Leu Leu Asn Glu Glu Val Ala Arg Arg 
    130                 135                 140                 


Ala Glu Lys Leu Leu Gly Phe Thr Pro Tyr Ser Leu Leu Trp Asn Asn 
145                 150                 155                 160 


Cys Glu His Phe Val Thr Tyr Cys Arg Tyr Gly Thr Pro Ile Ser Pro 
                165                 170                 175     


Gln Ser Asp Lys Phe Cys Glu Thr Val Lys Ile Ile Ile Arg Asp Gln 
            180                 185                 190         


Arg Ser Val Leu Ala Ser Ala Val Leu Gly Leu Ala Ser Ile Val Cys 
        195                 200                 205             


Thr Gly Leu Val Ser Tyr Thr Thr Leu Pro Ala Ile Phe Ile Pro Phe 
    210                 215                 220                 


Phe Leu Trp Met Ala Gly 
225                 230 


<210>  7984
<211>  230
<212>  PRT
<213>  Homo Sapiens

<400>  7984

Met Lys Asn Pro Met Leu Glu Val Val Ser Leu Leu Leu Glu Lys Leu 
1               5                   10                  15      


Leu Leu Ile Ser Asn Phe Thr Leu Phe Ser Ser Gly Ala Ala Gly Glu 
            20                  25                  30          


Asp Lys Gly Arg Asn Ser Phe Tyr Glu Thr Ser Ser Phe His Arg Gly 
        35                  40                  45              


Asp Val Leu Glu Val Pro Arg Thr His Leu Thr His Tyr Gly Ile Tyr 
    50                  55                  60                  


Leu Gly Asp Asn Arg Val Ala His Met Met Pro Asp Ile Leu Leu Ala 
65                  70                  75                  80  


Leu Thr Asp Asp Met Gly Arg Thr Gln Lys Val Val Ser Asn Lys Arg 
                85                  90                  95      


Leu Ile Leu Gly Val Ile Val Lys Val Ala Ser Ile Arg Val Asp Thr 
            100                 105                 110         


Val Glu Asp Phe Ala Tyr Gly Ala Asn Ile Leu Val Asn His Leu Asp 
        115                 120                 125             


Glu Ser Leu Gln Lys Lys Ala Leu Leu Asn Glu Glu Val Ala Arg Arg 
    130                 135                 140                 


Ala Glu Lys Leu Leu Gly Phe Thr Pro Tyr Ser Leu Leu Trp Asn Asn 
145                 150                 155                 160 


Cys Glu His Phe Val Thr Tyr Cys Arg Tyr Gly Thr Pro Ile Ser Pro 
                165                 170                 175     


Gln Ser Asp Lys Phe Cys Glu Thr Val Lys Ile Ile Ile Arg Asp Gln 
            180                 185                 190         


Arg Ser Val Leu Ala Ser Ala Val Leu Gly Leu Ala Ser Ile Val Cys 
        195                 200                 205             


Thr Gly Leu Val Ser Tyr Thr Thr Leu Pro Ala Ile Phe Ile Pro Phe 
    210                 215                 220                 


Phe Leu Trp Met Ala Gly 
225                 230 


<210>  7985
<211>  214
<212>  PRT
<213>  Homo Sapiens

<400>  7985

Ala Val Leu Asp Phe Val Lys Gln Lys Ala Ser Gln Ser Pro Gln Lys 
1               5                   10                  15      


Gln His Pro Leu Leu Asp Gly Val Asp Gly Glu Cys Pro Phe Pro Ser 
            20                  25                  30          


Arg Arg Ser Gln His Thr Asp Asp Ser Ala Leu Cys Met Ser Asp Asp 
        35                  40                  45              


Arg Pro Asn Ala Leu Leu Ser Ser Pro Ala Thr Glu Thr Gly His Ala 
    50                  55                  60                  


Ser Pro Leu Pro Pro Ser Ala Ala Pro Thr Thr Asp Ser Thr Asp Ser 
65                  70                  75                  80  


Ile Thr Gly Gln Asn Ser Arg Gln Arg Glu Glu Glu Leu Glu Leu Ile 
                85                  90                  95      


Asp Gln Leu Arg Lys His Ile Glu Tyr Arg Leu Lys Val Ser Leu Pro 
            100                 105                 110         


Cys Asp Leu Gly Ala Ala Leu Thr Asp Gly Val Val Leu Cys His Leu 
        115                 120                 125             


Ala Asn His Val Arg Pro Arg Ser Val Pro Ser Ile His Val Pro Ser 
    130                 135                 140                 


Pro Ala Val Pro Lys Leu Thr Met Ala Lys Cys Arg Arg Asn Val Glu 
145                 150                 155                 160 


Asn Phe Leu Glu Ala Cys Arg Lys Ile Gly Val Pro Gln Glu Gln Leu 
                165                 170                 175     


Cys Leu Pro Leu His Ile Leu Glu Glu Lys Gly Leu Ser Gln Val Ala 
            180                 185                 190         


Val Thr Val Gln Ala Leu Leu Glu Leu Ala Pro Pro Lys Gln Gln Gln 
        195                 200                 205             


His Gln Leu Ser Ala Val 
    210                 


<210>  7986
<211>  712
<212>  PRT
<213>  Homo Sapiens

<400>  7986

Met Ala Ala Ala Gly Leu Val Ala Val Ala Ala Ala Ala Glu Tyr Ser 
1               5                   10                  15      


Gly Thr Val Ala Ser Gly Gly Asn Leu Pro Gly Val His Cys Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Gly Pro Gly Phe Gly Pro Gly Ser Trp Ser Arg Ser 
        35                  40                  45              


Leu Asp Arg Ala Leu Glu Glu Ala Ala Val Thr Gly Val Leu Ser Leu 
    50                  55                  60                  


Ser Gly Arg Lys Leu Arg Glu Phe Pro Arg Gly Ala Ala Asn His Asp 
65                  70                  75                  80  


Leu Thr Asp Thr Thr Arg Ala Asp Leu Ser Arg Asn Arg Leu Ser Glu 
                85                  90                  95      


Ile Pro Ile Glu Ala Cys His Phe Val Ser Leu Glu Asn Leu Asn Leu 
            100                 105                 110         


Tyr Gln Asn Cys Ile Arg Tyr Ile Pro Glu Ala Ile Leu Asn Leu Gln 
        115                 120                 125             


Ala Leu Thr Phe Leu Asn Ile Ser Arg Asn Gln Leu Ser Thr Leu Pro 
    130                 135                 140                 


Val His Leu Cys Asn Leu Pro Leu Lys Val Leu Ile Ala Ser Asn Asn 
145                 150                 155                 160 


Lys Leu Val Ser Leu Pro Glu Glu Ile Gly His Leu Arg His Leu Met 
                165                 170                 175     


Glu Leu Asp Val Ser Cys Asn Glu Ile Gln Thr Ile Pro Ser Gln Ile 
            180                 185                 190         


Gly Asn Leu Glu Ala Leu Arg Asp Leu Asn Val Arg Arg Asn His Leu 
        195                 200                 205             


Val His Leu Pro Glu Glu Leu Ala Glu Leu Pro Leu Ile Arg Leu Asp 
    210                 215                 220                 


Phe Ser Cys Asn Lys Ile Thr Thr Ile Pro Val Cys Tyr Arg Asn Leu 
225                 230                 235                 240 


Arg His Leu Gln Thr Ile Thr Leu Asp Asn Asn Pro Leu Gln Ser Pro 
                245                 250                 255     


Pro Ala Gln Ile Cys Ile Lys Gly Lys Val His Ile Phe Lys Tyr Leu 
            260                 265                 270         


Asn Ile Gln Ala Cys Lys Ile Ala Pro Asp Leu Pro Asp Tyr Asp Arg 
        275                 280                 285             


Arg Pro Leu Gly Phe Gly Ser Cys His Glu Glu Leu Tyr Ser Ser Arg 
    290                 295                 300                 


Pro Tyr Gly Ala Leu Asp Ser Gly Phe Asn Ser Val Asp Ser Gly Asp 
305                 310                 315                 320 


Lys Arg Trp Ser Gly Asn Glu Pro Thr Asp Glu Phe Ser Asp Leu Pro 
                325                 330                 335     


Leu Arg Val Ala Glu Ile Thr Lys Glu Gln Arg Leu Arg Arg Glu Ser 
            340                 345                 350         


Gln Tyr Gln Glu Asn Arg Gly Ser Leu Val Val Thr Asn Gly Gly Val 
        355                 360                 365             


Glu His Asp Leu Asp Gln Ile Asp Tyr Ile Asp Ser Cys Thr Ala Glu 
    370                 375                 380                 


Glu Glu Glu Ala Glu Val Arg Gln Pro Lys Gly Pro Asp Pro Asp Ser 
385                 390                 395                 400 


Leu Ser Ser Gln Phe Met Ala Tyr Ile Glu Gln Arg Arg Ile Ser His 
                405                 410                 415     


Glu Gly Ser Pro Val Lys Pro Val Ala Ile Arg Glu Phe Gln Lys Thr 
            420                 425                 430         


Glu Asp Met Arg Arg Tyr Leu His Gln Asn Arg Val Pro Ala Glu Pro 
        435                 440                 445             


Ser Ser Leu Leu Ser Leu Ser Ala Ser His Asn Gln Leu Ser His Thr 
    450                 455                 460                 


Asp Leu Glu Leu His Gln Arg Arg Glu Gln Leu Val Glu Arg Thr Arg 
465                 470                 475                 480 


Arg Glu Ala Gln Leu Ala Ala Leu Gln Tyr Glu Glu Glu Lys Ile Arg 
                485                 490                 495     


Thr Lys Gln Ile Gln Arg Asp Ala Val Leu Asp Phe Val Lys Gln Lys 
            500                 505                 510         


Ala Ser Gln Ser Pro Gln Lys Gln His Pro Leu Leu Asp Gly Val Asp 
        515                 520                 525             


Gly Glu Cys Pro Phe Pro Ser Arg Arg Ser Gln His Thr Asp Asp Ser 
    530                 535                 540                 


Ala Leu Cys Met Ser Leu Ser Gly Leu Asn Gln Val Gly Cys Ala Ala 
545                 550                 555                 560 


Thr Leu Pro His Ser Ser Ala Phe Thr Pro Leu Lys Ser Asp Asp Arg 
                565                 570                 575     


Pro Asn Ala Leu Leu Ser Ser Pro Ala Thr Glu Thr Val His His Ser 
            580                 585                 590         


Pro Ala Tyr Ser Phe Pro Ala Ala Ile Gln Arg Asn Gln Pro Gln Arg 
        595                 600                 605             


Pro Glu Ser Phe Leu Phe Arg Ala Gly Val Arg Ala Glu Thr Asn Lys 
    610                 615                 620                 


Gly His Ala Ser Pro Leu Pro Pro Ser Ala Ala Pro Thr Thr Asp Ser 
625                 630                 635                 640 


Thr Asp Ser Ile Thr Gly Gln Asn Ser Arg Gln Arg Glu Glu Glu Leu 
                645                 650                 655     


Glu Leu Ile Asp Gln Leu Arg Lys His Ile Glu Tyr Arg Leu Lys Val 
            660                 665                 670         


Ser Leu Pro Cys Asp Leu Gly Ala Ala Leu Thr Asp Gly Val Val Leu 
        675                 680                 685             


Cys His Leu Ala Asn His Val Arg Pro Arg Ser Val Pro Ser Ile His 
    690                 695                 700                 


Val Pro Ser Pro Ala Val Val Ser 
705                 710         


<210>  7987
<211>  725
<212>  PRT
<213>  Homo Sapiens

<400>  7987

Met Ala Ala Ala Gly Leu Val Ala Val Ala Ala Ala Ala Glu Tyr Ser 
1               5                   10                  15      


Gly Thr Val Ala Ser Gly Gly Asn Leu Pro Gly Val His Cys Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Gly Pro Gly Phe Gly Pro Gly Ser Trp Ser Arg Ser 
        35                  40                  45              


Leu Asp Arg Ala Leu Glu Glu Ala Ala Val Thr Gly Val Leu Ser Leu 
    50                  55                  60                  


Ser Gly Arg Lys Leu Arg Glu Phe Pro Arg Gly Ala Ala Asn His Asp 
65                  70                  75                  80  


Leu Thr Asp Thr Thr Arg Ala Asp Leu Ser Arg Asn Arg Leu Ser Glu 
                85                  90                  95      


Ile Pro Ile Glu Ala Cys His Phe Val Ser Leu Glu Asn Leu Asn Leu 
            100                 105                 110         


Tyr Gln Asn Cys Ile Arg Tyr Ile Pro Glu Ala Ile Leu Asn Leu Gln 
        115                 120                 125             


Ala Leu Thr Phe Leu Asn Ile Ser Arg Asn Gln Leu Ser Thr Leu Pro 
    130                 135                 140                 


Val His Leu Cys Asn Leu Pro Leu Lys Val Leu Ile Ala Ser Asn Asn 
145                 150                 155                 160 


Lys Leu Val Ser Leu Pro Glu Glu Ile Gly His Leu Arg His Leu Met 
                165                 170                 175     


Glu Leu Asp Val Ser Cys Asn Glu Ile Gln Thr Ile Pro Ser Gln Ile 
            180                 185                 190         


Gly Asn Leu Glu Ala Leu Arg Asp Leu Asn Val Arg Arg Asn His Leu 
        195                 200                 205             


Val His Leu Pro Glu Glu Leu Ala Glu Leu Pro Leu Ile Arg Leu Asp 
    210                 215                 220                 


Phe Ser Cys Asn Lys Ile Thr Thr Ile Pro Val Cys Tyr Arg Asn Leu 
225                 230                 235                 240 


Arg His Leu Gln Thr Ile Thr Leu Asp Asn Asn Pro Leu Gln Ser Pro 
                245                 250                 255     


Pro Ala Gln Ile Cys Ile Lys Gly Lys Val His Ile Phe Lys Tyr Leu 
            260                 265                 270         


Asn Ile Gln Ala Cys Lys Ile Ala Pro Asp Leu Pro Asp Tyr Asp Arg 
        275                 280                 285             


Arg Pro Leu Gly Phe Gly Ser Cys His Glu Glu Leu Tyr Ser Ser Arg 
    290                 295                 300                 


Pro Tyr Gly Ala Leu Asp Ser Gly Phe Asn Ser Val Asp Ser Gly Asp 
305                 310                 315                 320 


Lys Arg Trp Ser Gly Asn Glu Pro Thr Asp Glu Phe Ser Asp Leu Pro 
                325                 330                 335     


Leu Arg Val Ala Glu Ile Thr Lys Glu Gln Arg Leu Arg Arg Glu Ser 
            340                 345                 350         


Gln Tyr Gln Glu Asn Arg Gly Ser Leu Val Val Thr Asn Gly Gly Val 
        355                 360                 365             


Glu His Asp Leu Asp Gln Ile Asp Tyr Ile Asp Ser Cys Thr Ala Glu 
    370                 375                 380                 


Glu Glu Glu Ala Glu Gly Ser Pro Val Lys Pro Val Ala Ile Arg Glu 
385                 390                 395                 400 


Phe Gln Lys Thr Glu Asp Met Arg Arg Tyr Leu His Gln Asn Arg Val 
                405                 410                 415     


Pro Ala Glu Pro Ser Ser Leu Leu Ser Leu Ser Ala Ser His Asn Gln 
            420                 425                 430         


Leu Ser His Thr Asp Leu Glu Leu His Gln Arg Arg Glu Gln Leu Val 
        435                 440                 445             


Glu Arg Thr Arg Arg Glu Ala Gln Leu Ala Ala Leu Gln Tyr Glu Glu 
    450                 455                 460                 


Glu Lys Ile Arg Thr Lys Gln Ile Gln Arg Asp Ala Val Leu Asp Phe 
465                 470                 475                 480 


Val Lys Gln Lys Ala Ser Gln Ser Pro Gln Lys Gln His Pro Leu Leu 
                485                 490                 495     


Asp Gly Val Asp Gly Glu Cys Pro Phe Pro Ser Arg Arg Ser Gln His 
            500                 505                 510         


Thr Asp Asp Ser Ala Leu Cys Met Ser Asp Asp Arg Pro Asn Ala Leu 
        515                 520                 525             


Leu Ser Ser Pro Ala Thr Glu Thr Val His His Ser Pro Ala Tyr Ser 
    530                 535                 540                 


Phe Pro Ala Ala Ile Gln Arg Asn Gln Pro Gln Arg Pro Glu Ser Phe 
545                 550                 555                 560 


Leu Phe Arg Ala Gly Val Arg Ala Glu Thr Asn Lys Gly His Ala Ser 
                565                 570                 575     


Pro Leu Pro Pro Ser Ala Ala Pro Thr Thr Asp Ser Thr Asp Ser Ile 
            580                 585                 590         


Thr Gly Gln Asn Ser Arg Gln Arg Glu Glu Glu Leu Glu Leu Ile Asp 
        595                 600                 605             


Gln Leu Arg Lys His Ile Glu Tyr Arg Leu Lys Val Ser Leu Pro Cys 
    610                 615                 620                 


Asp Leu Gly Ala Ala Leu Thr Asp Gly Val Val Leu Cys His Leu Ala 
625                 630                 635                 640 


Asn His Val Arg Pro Arg Ser Val Pro Ser Ile His Val Pro Ser Pro 
                645                 650                 655     


Ala Val Pro Lys Leu Thr Met Ala Lys Cys Arg Arg Asn Val Glu Asn 
            660                 665                 670         


Phe Leu Glu Ala Cys Arg Lys Ile Gly Val Pro Gln Glu Gln Leu Cys 
        675                 680                 685             


Leu Pro Leu His Ile Leu Glu Glu Lys Gly Leu Ser Gln Val Ala Val 
    690                 695                 700                 


Thr Val Gln Ala Leu Leu Glu Leu Ala Pro Pro Lys Gln Gln Gln His 
705                 710                 715                 720 


Gln Leu Ser Ala Val 
                725 


<210>  7988
<211>  803
<212>  PRT
<213>  Homo Sapiens

<400>  7988

Met Ala Ala Ala Gly Leu Val Ala Val Ala Ala Ala Ala Glu Tyr Ser 
1               5                   10                  15      


Gly Thr Val Ala Ser Gly Gly Asn Leu Pro Gly Val His Cys Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Gly Pro Gly Phe Gly Pro Gly Ser Trp Ser Arg Ser 
        35                  40                  45              


Leu Asp Arg Ala Leu Glu Glu Ala Ala Val Thr Gly Val Leu Ser Leu 
    50                  55                  60                  


Ser Gly Arg Lys Leu Arg Glu Phe Pro Arg Gly Ala Ala Asn His Asp 
65                  70                  75                  80  


Leu Thr Asp Thr Thr Arg Ala Asp Leu Ser Arg Asn Arg Leu Ser Glu 
                85                  90                  95      


Ile Pro Ile Glu Ala Cys His Phe Val Ser Leu Glu Asn Leu Asn Leu 
            100                 105                 110         


Tyr Gln Asn Cys Ile Arg Tyr Ile Pro Glu Ala Ile Leu Asn Leu Gln 
        115                 120                 125             


Ala Leu Thr Phe Leu Asn Ile Ser Arg Asn Gln Leu Ser Thr Leu Pro 
    130                 135                 140                 


Val His Leu Cys Asn Leu Pro Leu Lys Val Leu Ile Ala Ser Asn Asn 
145                 150                 155                 160 


Lys Leu Val Ser Leu Pro Glu Glu Ile Gly His Leu Arg His Leu Met 
                165                 170                 175     


Glu Leu Asp Val Ser Cys Asn Glu Ile Gln Thr Ile Pro Ser Gln Ile 
            180                 185                 190         


Gly Asn Leu Glu Ala Leu Arg Asp Leu Asn Val Arg Arg Asn His Leu 
        195                 200                 205             


Val His Leu Pro Glu Glu Leu Ala Glu Leu Pro Leu Ile Arg Leu Asp 
    210                 215                 220                 


Phe Ser Cys Asn Lys Ile Thr Thr Ile Pro Val Cys Tyr Arg Asn Leu 
225                 230                 235                 240 


Arg His Leu Gln Thr Ile Thr Leu Asp Asn Asn Pro Leu Gln Ser Pro 
                245                 250                 255     


Pro Ala Gln Ile Cys Ile Lys Gly Lys Val His Ile Phe Lys Tyr Leu 
            260                 265                 270         


Asn Ile Gln Ala Cys Lys Ile Ala Pro Asp Leu Pro Asp Tyr Asp Arg 
        275                 280                 285             


Arg Pro Leu Gly Phe Gly Ser Cys His Glu Glu Leu Tyr Ser Ser Arg 
    290                 295                 300                 


Pro Tyr Gly Ala Leu Asp Ser Gly Phe Asn Ser Val Asp Ser Gly Asp 
305                 310                 315                 320 


Lys Arg Trp Ser Gly Asn Glu Pro Thr Asp Glu Phe Ser Asp Leu Pro 
                325                 330                 335     


Leu Arg Val Ala Glu Ile Thr Lys Glu Gln Arg Leu Arg Arg Glu Ser 
            340                 345                 350         


Gln Tyr Gln Glu Asn Arg Gly Ser Leu Val Val Thr Asn Gly Gly Val 
        355                 360                 365             


Glu His Asp Leu Asp Gln Ile Asp Tyr Ile Asp Ser Cys Thr Ala Glu 
    370                 375                 380                 


Glu Glu Glu Ala Glu Val Arg Gln Pro Lys Gly Pro Asp Pro Asp Ser 
385                 390                 395                 400 


Leu Ser Ser Gln Phe Met Ala Tyr Ile Glu Gln Arg Arg Ile Ser His 
                405                 410                 415     


Glu Gly Ser Pro Val Lys Pro Val Ala Ile Arg Glu Phe Gln Lys Thr 
            420                 425                 430         


Glu Asp Met Arg Arg Tyr Leu His Gln Asn Arg Val Pro Ala Glu Pro 
        435                 440                 445             


Ser Ser Leu Leu Ser Leu Ser Ala Ser His Asn Gln Leu Ser His Thr 
    450                 455                 460                 


Asp Leu Glu Leu His Gln Arg Arg Glu Gln Leu Val Glu Arg Thr Arg 
465                 470                 475                 480 


Arg Glu Ala Gln Leu Ala Ala Leu Gln Tyr Glu Glu Glu Lys Ile Arg 
                485                 490                 495     


Thr Lys Gln Ile Gln Arg Asp Ala Val Leu Asp Phe Val Lys Gln Lys 
            500                 505                 510         


Ala Ser Gln Ser Pro Gln Lys Gln His Pro Leu Leu Asp Gly Val Asp 
        515                 520                 525             


Gly Glu Cys Pro Phe Pro Ser Arg Arg Ser Gln His Thr Asp Asp Ser 
    530                 535                 540                 


Ala Leu Cys Met Ser Leu Ser Gly Leu Asn Gln Val Gly Cys Ala Ala 
545                 550                 555                 560 


Thr Leu Pro His Ser Ser Ala Phe Thr Pro Leu Lys Ser Asp Asp Arg 
                565                 570                 575     


Pro Asn Ala Leu Leu Ser Ser Pro Ala Thr Glu Thr Val His His Ser 
            580                 585                 590         


Pro Ala Tyr Ser Phe Pro Ala Ala Ile Gln Arg Asn Gln Pro Gln Arg 
        595                 600                 605             


Pro Glu Ser Phe Leu Phe Arg Ala Gly Val Arg Ala Glu Thr Asn Lys 
    610                 615                 620                 


Gly His Ala Ser Pro Leu Pro Pro Ser Ala Ala Pro Thr Thr Asp Ser 
625                 630                 635                 640 


Thr Asp Ser Ile Thr Gly Gln Asn Ser Arg Gln Arg Glu Glu Glu Leu 
                645                 650                 655     


Glu Leu Ile Asp Gln Leu Arg Lys His Ile Glu Tyr Arg Leu Lys Val 
            660                 665                 670         


Ser Leu Pro Cys Asp Leu Gly Ala Ala Leu Thr Asp Gly Val Val Leu 
        675                 680                 685             


Cys His Leu Ala Asn His Val Arg Pro Arg Ser Val Pro Ser Ile His 
    690                 695                 700                 


Val Pro Ser Pro Ala Val Pro Lys Leu Thr Met Ala Lys Cys Arg Arg 
705                 710                 715                 720 


Asn Val Glu Asn Phe Leu Glu Ala Cys Arg Lys Ile Gly Val Pro Gln 
                725                 730                 735     


Asp Asn Leu Cys Ser Pro Ser Asp Ile Leu Gln Leu Asn Leu Ser Val 
            740                 745                 750         


Lys Arg Thr Val Glu Thr Leu Leu Ser Leu Gly Ala His Ser Glu Glu 
        755                 760                 765             


Ser Ser Phe Val Cys Leu Ser Leu Gln Leu Leu Gly Phe Val Ala Phe 
    770                 775                 780                 


Tyr Cys Thr Val Met Leu Thr Leu Cys Val Leu Tyr Tyr Trp Leu Phe 
785                 790                 795                 800 


Pro Ala Arg 
            


<210>  7989
<211>  777
<212>  PRT
<213>  Homo Sapiens

<400>  7989

Met Ala Ala Ala Gly Leu Val Ala Val Ala Ala Ala Ala Glu Tyr Ser 
1               5                   10                  15      


Gly Thr Val Ala Ser Gly Gly Asn Leu Pro Gly Val His Cys Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Gly Pro Gly Phe Gly Pro Gly Ser Trp Ser Arg Ser 
        35                  40                  45              


Leu Asp Arg Ala Leu Glu Glu Ala Ala Val Thr Gly Val Leu Ser Leu 
    50                  55                  60                  


Ser Gly Arg Lys Leu Arg Glu Phe Pro Arg Gly Ala Ala Asn His Asp 
65                  70                  75                  80  


Leu Thr Asp Thr Thr Arg Ala Asp Leu Ser Arg Asn Arg Leu Ser Glu 
                85                  90                  95      


Ile Pro Ile Glu Ala Cys His Phe Val Ser Leu Glu Asn Leu Asn Leu 
            100                 105                 110         


Tyr Gln Asn Cys Ile Arg Tyr Ile Pro Glu Ala Ile Leu Asn Leu Gln 
        115                 120                 125             


Ala Leu Thr Phe Leu Asn Ile Ser Arg Asn Gln Leu Ser Thr Leu Pro 
    130                 135                 140                 


Val His Leu Cys Asn Leu Pro Leu Lys Val Leu Ile Ala Ser Asn Asn 
145                 150                 155                 160 


Lys Leu Val Ser Leu Pro Glu Glu Ile Gly His Leu Arg His Leu Met 
                165                 170                 175     


Glu Leu Asp Val Ser Cys Asn Glu Ile Gln Thr Ile Pro Ser Gln Ile 
            180                 185                 190         


Gly Asn Leu Glu Ala Leu Arg Asp Leu Asn Val Arg Arg Asn His Leu 
        195                 200                 205             


Val His Leu Pro Glu Glu Leu Ala Glu Leu Pro Leu Ile Arg Leu Asp 
    210                 215                 220                 


Phe Ser Cys Asn Lys Ile Thr Thr Ile Pro Val Cys Tyr Arg Asn Leu 
225                 230                 235                 240 


Arg His Leu Gln Thr Ile Thr Leu Asp Asn Asn Pro Leu Gln Ser Pro 
                245                 250                 255     


Pro Ala Gln Ile Cys Ile Lys Gly Lys Val His Ile Phe Lys Tyr Leu 
            260                 265                 270         


Asn Ile Gln Ala Cys Lys Ile Ala Pro Asp Leu Pro Asp Tyr Asp Arg 
        275                 280                 285             


Arg Pro Leu Gly Phe Gly Ser Cys His Glu Glu Leu Tyr Ser Ser Arg 
    290                 295                 300                 


Pro Tyr Gly Ala Leu Asp Ser Gly Phe Asn Ser Val Asp Ser Gly Asp 
305                 310                 315                 320 


Lys Arg Trp Ser Gly Asn Glu Pro Thr Asp Glu Phe Ser Asp Leu Pro 
                325                 330                 335     


Leu Arg Val Ala Glu Ile Thr Lys Glu Gln Arg Leu Arg Arg Glu Ser 
            340                 345                 350         


Gln Tyr Gln Glu Asn Arg Gly Ser Leu Val Val Thr Asn Gly Gly Val 
        355                 360                 365             


Glu His Asp Leu Asp Gln Ile Asp Tyr Ile Asp Ser Cys Thr Ala Glu 
    370                 375                 380                 


Glu Glu Glu Ala Glu Val Arg Gln Pro Lys Gly Pro Asp Pro Asp Ser 
385                 390                 395                 400 


Leu Ser Ser Gln Phe Met Ala Tyr Ile Glu Gln Arg Arg Ile Ser His 
                405                 410                 415     


Glu Gly Ser Pro Val Lys Pro Val Ala Ile Arg Glu Phe Gln Lys Thr 
            420                 425                 430         


Glu Asp Met Arg Arg Tyr Leu His Gln Asn Arg Val Pro Ala Glu Pro 
        435                 440                 445             


Ser Ser Leu Leu Ser Leu Ser Ala Ser His Asn Gln Leu Ser His Thr 
    450                 455                 460                 


Asp Leu Glu Leu His Gln Arg Arg Glu Gln Leu Val Glu Arg Thr Arg 
465                 470                 475                 480 


Arg Glu Ala Gln Leu Ala Ala Leu Gln Tyr Glu Glu Glu Lys Ile Arg 
                485                 490                 495     


Thr Lys Gln Ile Gln Arg Asp Ala Val Leu Asp Phe Val Lys Gln Lys 
            500                 505                 510         


Ala Ser Gln Ser Pro Gln Lys Gln His Pro Leu Leu Asp Gly Val Asp 
        515                 520                 525             


Gly Glu Cys Pro Phe Pro Ser Arg Arg Ser Gln His Thr Asp Asp Ser 
    530                 535                 540                 


Ala Leu Cys Met Ser Leu Ser Gly Leu Asn Gln Val Gly Cys Ala Ala 
545                 550                 555                 560 


Thr Leu Pro His Ser Ser Ala Phe Thr Pro Leu Lys Ser Asp Asp Arg 
                565                 570                 575     


Pro Asn Ala Leu Leu Ser Ser Pro Ala Thr Glu Thr Val His His Ser 
            580                 585                 590         


Pro Ala Tyr Ser Phe Pro Ala Ala Ile Gln Arg Asn Gln Pro Gln Arg 
        595                 600                 605             


Pro Glu Ser Phe Leu Phe Arg Ala Gly Val Arg Ala Glu Thr Asn Lys 
    610                 615                 620                 


Gly His Ala Ser Pro Leu Pro Pro Ser Ala Ala Pro Thr Thr Asp Ser 
625                 630                 635                 640 


Thr Asp Ser Ile Thr Gly Gln Asn Ser Arg Gln Arg Glu Glu Glu Leu 
                645                 650                 655     


Glu Leu Ile Asp Gln Leu Arg Lys His Ile Glu Tyr Arg Leu Lys Val 
            660                 665                 670         


Ser Leu Pro Cys Asp Leu Gly Ala Ala Leu Thr Asp Gly Val Val Leu 
        675                 680                 685             


Cys His Leu Ala Asn His Val Arg Pro Arg Ser Val Pro Ser Ile His 
    690                 695                 700                 


Val Pro Ser Pro Ala Val Pro Lys Leu Thr Met Ala Lys Cys Arg Arg 
705                 710                 715                 720 


Asn Val Glu Asn Phe Leu Glu Ala Cys Arg Lys Ile Gly Val Pro Gln 
                725                 730                 735     


Glu Gln Leu Cys Leu Pro Leu His Ile Leu Glu Glu Lys Gly Leu Ser 
            740                 745                 750         


Gln Val Ala Val Thr Val Gln Ala Leu Leu Glu Leu Ala Pro Pro Lys 
        755                 760                 765             


Gln Gln Gln His Gln Leu Ser Ala Val 
    770                 775         


<210>  7990
<211>  803
<212>  PRT
<213>  Homo Sapiens

<400>  7990

Met Ala Ala Ala Gly Leu Val Ala Val Ala Ala Ala Ala Glu Tyr Ser 
1               5                   10                  15      


Gly Thr Val Ala Ser Gly Gly Asn Leu Pro Gly Val His Cys Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Gly Pro Gly Phe Gly Pro Gly Ser Trp Ser Arg Ser 
        35                  40                  45              


Leu Asp Arg Ala Leu Glu Glu Ala Ala Val Thr Gly Val Leu Ser Leu 
    50                  55                  60                  


Ser Gly Arg Lys Leu Arg Glu Phe Pro Arg Gly Ala Ala Asn His Asp 
65                  70                  75                  80  


Leu Thr Asp Thr Thr Arg Ala Asp Leu Ser Arg Asn Arg Leu Ser Glu 
                85                  90                  95      


Ile Pro Ile Glu Ala Cys His Phe Val Ser Leu Glu Asn Leu Asn Leu 
            100                 105                 110         


Tyr Gln Asn Cys Ile Arg Tyr Ile Pro Glu Ala Ile Leu Asn Leu Gln 
        115                 120                 125             


Ala Leu Thr Phe Leu Asn Ile Ser Arg Asn Gln Leu Ser Thr Leu Pro 
    130                 135                 140                 


Val His Leu Cys Asn Leu Pro Leu Lys Val Leu Ile Ala Ser Asn Asn 
145                 150                 155                 160 


Lys Leu Val Ser Leu Pro Glu Glu Ile Gly His Leu Arg His Leu Met 
                165                 170                 175     


Glu Leu Asp Val Ser Cys Asn Glu Ile Gln Thr Ile Pro Ser Gln Ile 
            180                 185                 190         


Gly Asn Leu Glu Ala Leu Arg Asp Leu Asn Val Arg Arg Asn His Leu 
        195                 200                 205             


Val His Leu Pro Glu Glu Leu Ala Glu Leu Pro Leu Ile Arg Leu Asp 
    210                 215                 220                 


Phe Ser Cys Asn Lys Ile Thr Thr Ile Pro Val Cys Tyr Arg Asn Leu 
225                 230                 235                 240 


Arg His Leu Gln Thr Ile Thr Leu Asp Asn Asn Pro Leu Gln Ser Pro 
                245                 250                 255     


Pro Ala Gln Ile Cys Ile Lys Gly Lys Val His Ile Phe Lys Tyr Leu 
            260                 265                 270         


Asn Ile Gln Ala Cys Lys Ile Ala Pro Asp Leu Pro Asp Tyr Asp Arg 
        275                 280                 285             


Arg Pro Leu Gly Phe Gly Ser Cys His Glu Glu Leu Tyr Ser Ser Arg 
    290                 295                 300                 


Pro Tyr Gly Ala Leu Asp Ser Gly Phe Asn Ser Val Asp Ser Gly Asp 
305                 310                 315                 320 


Lys Arg Trp Ser Gly Asn Glu Pro Thr Asp Glu Phe Ser Asp Leu Pro 
                325                 330                 335     


Leu Arg Val Ala Glu Ile Thr Lys Glu Gln Arg Leu Arg Arg Glu Ser 
            340                 345                 350         


Gln Tyr Gln Glu Asn Arg Gly Ser Leu Val Val Thr Asn Gly Gly Val 
        355                 360                 365             


Glu His Asp Leu Asp Gln Ile Asp Tyr Ile Asp Ser Cys Thr Ala Glu 
    370                 375                 380                 


Glu Glu Glu Ala Glu Val Arg Gln Pro Lys Gly Pro Asp Pro Asp Ser 
385                 390                 395                 400 


Leu Ser Ser Gln Phe Met Ala Tyr Ile Glu Gln Arg Arg Ile Ser His 
                405                 410                 415     


Glu Gly Ser Pro Val Lys Pro Val Ala Ile Arg Glu Phe Gln Lys Thr 
            420                 425                 430         


Glu Asp Met Arg Arg Tyr Leu His Gln Asn Arg Val Pro Ala Glu Pro 
        435                 440                 445             


Ser Ser Leu Leu Ser Leu Ser Ala Ser His Asn Gln Leu Ser His Thr 
    450                 455                 460                 


Asp Leu Glu Leu His Gln Arg Arg Glu Gln Leu Val Glu Arg Thr Arg 
465                 470                 475                 480 


Arg Glu Ala Gln Leu Ala Ala Leu Gln Tyr Glu Glu Glu Lys Ile Arg 
                485                 490                 495     


Thr Lys Gln Ile Gln Arg Asp Ala Val Leu Asp Phe Val Lys Gln Lys 
            500                 505                 510         


Ala Ser Gln Ser Pro Gln Lys Gln His Pro Leu Leu Asp Gly Val Asp 
        515                 520                 525             


Gly Glu Cys Pro Phe Pro Ser Arg Arg Ser Gln His Thr Asp Asp Ser 
    530                 535                 540                 


Ala Leu Cys Met Ser Leu Ser Gly Leu Asn Gln Val Gly Cys Ala Ala 
545                 550                 555                 560 


Thr Leu Pro His Ser Ser Ala Phe Thr Pro Leu Lys Ser Asp Asp Arg 
                565                 570                 575     


Pro Asn Ala Leu Leu Ser Ser Pro Ala Thr Glu Thr Val His His Ser 
            580                 585                 590         


Pro Ala Tyr Ser Phe Pro Ala Ala Ile Gln Arg Asn Gln Pro Gln Arg 
        595                 600                 605             


Pro Glu Ser Phe Leu Phe Arg Ala Gly Val Arg Ala Glu Thr Asn Lys 
    610                 615                 620                 


Gly His Ala Ser Pro Leu Pro Pro Ser Ala Ala Pro Thr Thr Asp Ser 
625                 630                 635                 640 


Thr Asp Ser Ile Thr Gly Gln Asn Ser Arg Gln Arg Glu Glu Glu Leu 
                645                 650                 655     


Glu Leu Ile Asp Gln Leu Arg Lys His Ile Glu Tyr Arg Leu Lys Val 
            660                 665                 670         


Ser Leu Pro Cys Asp Leu Gly Ala Ala Leu Thr Asp Gly Val Val Leu 
        675                 680                 685             


Cys His Leu Ala Asn His Val Arg Pro Arg Ser Val Pro Ser Ile His 
    690                 695                 700                 


Val Pro Ser Pro Ala Val Pro Lys Leu Thr Met Ala Lys Cys Arg Arg 
705                 710                 715                 720 


Asn Val Glu Asn Phe Leu Glu Ala Cys Arg Lys Ile Gly Val Pro Gln 
                725                 730                 735     


Asp Asn Leu Cys Ser Pro Ser Asp Ile Leu Gln Leu Asn Leu Ser Val 
            740                 745                 750         


Lys Arg Thr Val Glu Thr Leu Leu Ser Leu Gly Ala His Ser Glu Glu 
        755                 760                 765             


Ser Ser Phe Val Cys Leu Ser Leu Gln Leu Leu Gly Phe Val Ala Phe 
    770                 775                 780                 


Tyr Cys Thr Val Met Leu Thr Leu Cys Val Leu Tyr Tyr Trp Leu Phe 
785                 790                 795                 800 


Pro Ala Arg 
            


<210>  7991
<211>  623
<212>  PRT
<213>  Homo Sapiens

<400>  7991

Met Ala Ala Ala Gly Leu Val Ala Val Ala Ala Ala Ala Glu Tyr Ser 
1               5                   10                  15      


Gly Thr Val Ala Ser Gly Gly Asn Leu Pro Gly Val His Cys Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Gly Pro Gly Phe Gly Pro Gly Ser Trp Ser Arg Ser 
        35                  40                  45              


Leu Asp Arg Ala Leu Glu Glu Ala Ala Val Thr Gly Val Leu Ser Leu 
    50                  55                  60                  


Ser Gly Arg Lys Leu Arg Glu Phe Pro Arg Gly Ala Ala Asn His Asp 
65                  70                  75                  80  


Leu Thr Asp Thr Thr Arg Ala Glu Leu Ala Glu Leu Pro Leu Ile Arg 
                85                  90                  95      


Leu Asp Phe Ser Cys Asn Lys Ile Thr Thr Ile Pro Val Cys Tyr Arg 
            100                 105                 110         


Asn Leu Arg His Leu Gln Thr Ile Thr Leu Asp Asn Asn Pro Leu Gln 
        115                 120                 125             


Ser Pro Pro Ala Gln Ile Cys Ile Lys Gly Lys Val His Ile Phe Lys 
    130                 135                 140                 


Tyr Leu Asn Ile Gln Ala Cys Lys Ile Ala Pro Asp Leu Pro Asp Tyr 
145                 150                 155                 160 


Asp Arg Arg Pro Leu Gly Phe Gly Ser Cys His Glu Glu Leu Tyr Ser 
                165                 170                 175     


Ser Arg Pro Tyr Gly Ala Leu Asp Ser Gly Phe Asn Ser Val Asp Ser 
            180                 185                 190         


Gly Asp Lys Arg Trp Ser Gly Asn Glu Pro Thr Asp Glu Phe Ser Asp 
        195                 200                 205             


Leu Pro Leu Arg Val Ala Glu Ile Thr Lys Glu Gln Arg Leu Arg Arg 
    210                 215                 220                 


Glu Ser Gln Tyr Gln Glu Asn Arg Gly Ser Leu Val Val Thr Asn Gly 
225                 230                 235                 240 


Gly Val Glu His Asp Leu Asp Gln Ile Asp Tyr Ile Asp Ser Cys Thr 
                245                 250                 255     


Ala Glu Glu Glu Glu Ala Glu Gly Ser Pro Val Lys Pro Val Ala Ile 
            260                 265                 270         


Arg Glu Phe Gln Lys Thr Glu Asp Met Arg Arg Tyr Leu His Gln Asn 
        275                 280                 285             


Arg Val Pro Ala Glu Pro Ser Ser Leu Leu Ser Leu Ser Ala Ser His 
    290                 295                 300                 


Asn Gln Leu Ser His Thr Asp Leu Glu Leu His Gln Arg Arg Glu Gln 
305                 310                 315                 320 


Leu Val Glu Arg Thr Arg Arg Glu Ala Gln Leu Ala Ala Leu Gln Tyr 
                325                 330                 335     


Glu Glu Glu Lys Ile Arg Thr Lys Gln Ile Gln Arg Asp Ala Val Leu 
            340                 345                 350         


Asp Phe Val Lys Gln Lys Ala Ser Gln Ser Pro Gln Lys Gln His Pro 
        355                 360                 365             


Leu Leu Asp Gly Val Asp Gly Glu Cys Pro Phe Pro Ser Arg Arg Ser 
    370                 375                 380                 


Gln His Thr Asp Asp Ser Ala Leu Cys Met Ser Leu Ser Gly Leu Asn 
385                 390                 395                 400 


Gln Val Gly Cys Ala Ala Thr Leu Pro His Ser Ser Ala Phe Thr Pro 
                405                 410                 415     


Leu Lys Ser Asp Asp Arg Pro Asn Ala Leu Leu Ser Ser Pro Ala Thr 
            420                 425                 430         


Glu Thr Val His His Ser Pro Ala Tyr Ser Phe Pro Ala Ala Ile Gln 
        435                 440                 445             


Arg Asn Gln Pro Gln Arg Pro Glu Ser Phe Leu Phe Arg Ala Gly Val 
    450                 455                 460                 


Arg Ala Glu Thr Asn Lys Gly His Ala Ser Pro Leu Pro Pro Ser Ala 
465                 470                 475                 480 


Ala Pro Thr Thr Asp Ser Thr Asp Ser Ile Thr Gly Gln Asn Ser Arg 
                485                 490                 495     


Gln Arg Glu Glu Glu Leu Glu Leu Ile Asp Gln Leu Arg Lys His Ile 
            500                 505                 510         


Glu Tyr Arg Leu Lys Val Ser Leu Pro Cys Asp Leu Gly Ala Ala Leu 
        515                 520                 525             


Thr Asp Gly Val Val Leu Cys His Leu Ala Asn His Val Arg Pro Arg 
    530                 535                 540                 


Ser Val Pro Ser Ile His Val Pro Ser Pro Ala Val Pro Lys Leu Thr 
545                 550                 555                 560 


Met Ala Lys Cys Arg Arg Asn Val Glu Asn Phe Leu Glu Ala Cys Arg 
                565                 570                 575     


Lys Ile Gly Val Pro Gln Glu Gln Leu Cys Leu Pro Leu His Ile Leu 
            580                 585                 590         


Glu Glu Lys Gly Leu Ser Gln Val Ala Val Thr Val Gln Ala Leu Leu 
        595                 600                 605             


Glu Leu Ala Pro Pro Lys Gln Gln Gln His Gln Leu Ser Ala Val 
    610                 615                 620             


<210>  7992
<211>  92
<212>  PRT
<213>  Homo Sapiens

<400>  7992

Met Ala Ala Ala Gly Leu Val Ala Val Ala Ala Ala Ala Glu Tyr Ser 
1               5                   10                  15      


Gly Thr Val Ala Ser Gly Gly Asn Leu Pro Gly Val His Cys Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Gly Pro Gly Phe Gly Pro Gly Ser Trp Ser Arg Ser 
        35                  40                  45              


Leu Asp Arg Ala Leu Glu Glu Ala Ala Val Thr Gly Val Leu Ser Leu 
    50                  55                  60                  


Ser Gly Arg Lys Leu Arg Glu Phe Pro Arg Gly Ala Ala Asn His Asp 
65                  70                  75                  80  


Leu Thr Asp Thr Thr Arg Ala Gly Cys Glu Leu Gln 
                85                  90          


<210>  7993
<211>  227
<212>  PRT
<213>  Homo Sapiens

<400>  7993

Tyr Glu Glu Glu Lys Ile Arg Thr Lys Gln Ile Gln Arg Asp Ala Val 
1               5                   10                  15      


Leu Asp Phe Val Lys Gln Lys Ala Ser Gln Ser Pro Gln Lys Gln His 
            20                  25                  30          


Pro Leu Leu Asp Gly Val Asp Gly Glu Cys Pro Phe Pro Ser Arg Arg 
        35                  40                  45              


Ser Gln His Thr Asp Asp Ser Ala Leu Cys Met Ser Leu Ser Gly Leu 
    50                  55                  60                  


Asn Gln Val Gly Cys Ala Ala Thr Leu Pro His Ser Ser Ala Phe Thr 
65                  70                  75                  80  


Pro Leu Lys Ser Asp Asp Arg Pro Asn Ala Leu Leu Ser Ser Pro Ala 
                85                  90                  95      


Thr Glu Thr Gly His Ala Ser Pro Leu Pro Pro Ser Ala Ala Pro Thr 
            100                 105                 110         


Thr Asp Ser Thr Asp Ser Ile Thr Gly Gln Asn Ser Arg Gln Arg Glu 
        115                 120                 125             


Glu Glu Leu Glu Leu Ile Asp Gln Leu Arg Lys His Ile Glu Tyr Arg 
    130                 135                 140                 


Leu Lys Val Ser Leu Pro Cys Asp Leu Gly Ala Ala Leu Thr Asp Gly 
145                 150                 155                 160 


Val Val Leu Cys His Leu Ala Asn His Val Arg Pro Arg Ser Val Pro 
                165                 170                 175     


Ser Ile His Val Pro Ser Pro Ala Val Pro Lys Leu Thr Met Ala Lys 
            180                 185                 190         


Cys Arg Arg Asn Val Glu Asn Phe Leu Glu Ala Cys Arg Lys Ile Gly 
        195                 200                 205             


Val Pro Gln Asp Asn Leu Cys Ser Pro Ser Asp Ile Leu Gln Leu Asn 
    210                 215                 220                 


Leu Ser Val 
225         


<210>  7994
<211>  159
<212>  PRT
<213>  Homo Sapiens

<400>  7994

Met Ala Gly Pro Gly Trp Thr Leu Leu Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Gly Ser Met Ala Gly Tyr Gly Pro Gln Lys Lys Leu Asn Leu 
            20                  25                  30          


Ser His Lys Gly Ile Gly Glu Pro Cys Arg Arg His Glu Glu Cys Gln 
        35                  40                  45              


Ser Asn Cys Cys Thr Ile Asn Ser Leu Ala Pro His Thr Leu Cys Thr 
    50                  55                  60                  


Pro Lys Thr Ile Phe Leu Gln Cys Leu Pro Trp Arg Lys Pro Asn Gly 
65                  70                  75                  80  


Tyr Arg Cys Ser His Asp Ser Glu Cys Gln Ser Ser Cys Cys Val Arg 
                85                  90                  95      


Asn Asn Ser Pro Gln Glu Leu Cys Thr Pro Gln Ser Val Phe Leu Gln 
            100                 105                 110         


Cys Val Pro Trp Arg Lys Pro Asn Gly Asp Phe Cys Ser Ser His Gln 
        115                 120                 125             


Glu Cys His Ser Gln Cys Cys Ile Gln Leu Arg Glu Tyr Ser Pro Phe 
    130                 135                 140                 


Arg Cys Ile Pro Arg Thr Gly Ile Leu Ala Gln Cys Leu Pro Leu 
145                 150                 155                 


<210>  7995
<211>  139
<212>  PRT
<213>  Homo Sapiens

<400>  7995

Met Ala Gly Pro Gly Trp Thr Leu Leu Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Gly Ser Met Ala Gly Tyr Gly Pro Gln Lys Lys Leu Asn Leu 
            20                  25                  30          


Ser His Lys Gly Ile Gly Glu Pro Cys Arg Arg His Glu Glu Cys Gln 
        35                  40                  45              


Ser Asn Cys Cys Thr Ile Asn Ser Leu Ala Pro His Thr Leu Cys Thr 
    50                  55                  60                  


Pro Lys Thr Ile Phe Leu Gln Cys Leu Pro Trp Arg Lys Val Ser Pro 
65                  70                  75                  80  


Met Gly Thr Asp Ala Arg Thr Thr Gln Ser Ala Arg Ala Ala Ala Ala 
                85                  90                  95      


Ser Ala Thr Thr Ala Arg Arg Ser Cys Ala Arg Pro Lys Ala Ser Ser 
            100                 105                 110         


Cys Ser Val Cys Pro Gly Ala Ser Pro Thr Ala Thr Ser Ala Ala Ala 
        115                 120                 125             


Ile Arg Ser Val Thr Ala Ser Ala Ala Ser Ser 
    130                 135                 


<210>  7996
<211>  46
<212>  PRT
<213>  Homo Sapiens

<400>  7996

Met Ala Gly Pro Gly Trp Thr Leu Leu Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Gly Ser Met Ala Gly Tyr Gly Pro Gln Lys Lys Leu Asn Leu 
            20                  25                  30          


Ser His Lys Lys Leu Leu Arg Lys Pro Lys Phe Glu Gly Trp 
        35                  40                  45      


<210>  7997
<211>  61
<212>  PRT
<213>  Homo Sapiens

<400>  7997

Met Ala Gly Pro Gly Trp Thr Leu Leu Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Gly Ser Met Ala Gly Tyr Gly Pro Gln Lys Lys Leu Asn Leu 
            20                  25                  30          


Ser His Lys Pro Arg Ala Pro Ser Thr Asp Leu Pro Glu Pro Arg Gln 
        35                  40                  45              


Ser Gly Phe Val Pro Glu Thr Ser Gln Glu Thr Gln Val 
    50                  55                  60      


<210>  7998
<211>  635
<212>  PRT
<213>  Homo Sapiens

<400>  7998

Met Ala Pro Pro Leu Leu Leu Leu Leu Leu Ala Ser Gly Ala Ala Ala 
1               5                   10                  15      


Cys Pro Leu Pro Cys Val Cys Gln Asn Leu Ser Glu Ser Leu Ser Thr 
            20                  25                  30          


Leu Cys Ala His Arg Gly Leu Leu Phe Val Pro Pro Asn Val Asp Arg 
        35                  40                  45              


Arg Thr Val Glu Leu Arg Leu Ala Asp Asn Phe Ile Gln Ala Leu Gly 
    50                  55                  60                  


Pro Pro Asp Phe Arg Asn Met Thr Gly Leu Val Asp Leu Thr Leu Ser 
65                  70                  75                  80  


Arg Asn Ala Ile Thr Arg Ile Gly Ala Arg Ala Phe Gly Asp Leu Glu 
                85                  90                  95      


Ser Leu Arg Ser Leu His Leu Asp Gly Asn Arg Leu Val Glu Leu Gly 
            100                 105                 110         


Thr Gly Ser Leu Arg Gly Pro Val Asn Leu Gln His Leu Ile Leu Ser 
        115                 120                 125             


Gly Asn Gln Leu Gly Arg Ile Ala Pro Gly Ala Phe Asp Asp Phe Leu 
    130                 135                 140                 


Glu Ser Leu Glu Asp Leu Asp Leu Ser Tyr Asn Asn Leu Arg Gln Val 
145                 150                 155                 160 


Pro Trp Ala Gly Ile Gly Ala Met Pro Ala Leu His Thr Leu Asn Leu 
                165                 170                 175     


Asp His Asn Leu Ile Asp Ala Leu Pro Pro Gly Ala Phe Ala Gln Leu 
            180                 185                 190         


Gly Gln Leu Ser Arg Leu Asp Leu Thr Ser Asn Arg Leu Ala Thr Leu 
        195                 200                 205             


Ala Pro Asp Pro Leu Phe Ser Arg Gly Arg Asp Ala Glu Ala Ser Pro 
    210                 215                 220                 


Ala Pro Leu Val Leu Ser Phe Ser Gly Asn Pro Leu His Cys Asn Cys 
225                 230                 235                 240 


Glu Leu Leu Trp Leu Arg Arg Leu Ala Arg Pro Asp Asp Leu Glu Thr 
                245                 250                 255     


Cys Ala Ser Pro Pro Gly Leu Ala Gly Arg Tyr Phe Trp Ala Val Pro 
            260                 265                 270         


Glu Gly Glu Phe Ser Cys Glu Pro Pro Leu Ile Ala Arg His Thr Gln 
        275                 280                 285             


Arg Leu Trp Val Leu Glu Gly Gln Arg Ala Thr Leu Arg Cys Arg Ala 
    290                 295                 300                 


Leu Gly Asp Pro Ala Pro Thr Met His Trp Val Gly Pro Asp Asp Arg 
305                 310                 315                 320 


Leu Val Gly Asn Ser Ser Arg Ala Arg Ala Phe Pro Asn Gly Thr Leu 
                325                 330                 335     


Glu Ile Gly Val Thr Gly Ala Gly Asp Ala Gly Gly Tyr Thr Cys Ile 
            340                 345                 350         


Ala Thr Asn Pro Ala Gly Glu Ala Thr Ala Arg Val Glu Leu Arg Val 
        355                 360                 365             


Leu Ala Leu Pro His Gly Gly Asn Ser Ser Ala Glu Gly Gly Arg Pro 
    370                 375                 380                 


Gly Pro Ser Asp Ile Ala Ala Ser Ala Arg Thr Ala Ala Glu Gly Glu 
385                 390                 395                 400 


Gly Thr Leu Glu Ser Glu Pro Ala Val Gln Val Thr Glu Val Thr Ala 
                405                 410                 415     


Thr Ser Gly Leu Val Ser Trp Gly Pro Gly Arg Pro Ala Asp Pro Val 
            420                 425                 430         


Trp Met Phe Gln Ile Gln Tyr Asn Ser Ser Glu Asp Glu Thr Leu Ile 
        435                 440                 445             


Tyr Arg Ile Val Pro Ala Ser Ser His His Phe Leu Leu Lys His Leu 
    450                 455                 460                 


Val Pro Gly Ala Asp Tyr Asp Leu Cys Leu Leu Ala Leu Ser Pro Ala 
465                 470                 475                 480 


Ala Gly Pro Ser Asp Leu Thr Ala Thr Arg Leu Leu Gly Cys Ala His 
                485                 490                 495     


Phe Ser Thr Leu Pro Ala Ser Pro Leu Cys His Ala Leu Gln Ala His 
            500                 505                 510         


Val Leu Gly Gly Thr Leu Thr Val Ala Val Gly Gly Val Leu Val Ala 
        515                 520                 525             


Ala Leu Leu Val Phe Thr Val Ala Leu Leu Val Arg Gly Arg Gly Ala 
    530                 535                 540                 


Gly Asn Gly Arg Leu Pro Leu Lys Leu Ser His Val Gln Ser Gln Thr 
545                 550                 555                 560 


Asn Gly Gly Pro Ser Pro Thr Pro Lys Ala His Pro Pro Arg Ser Pro 
                565                 570                 575     


Pro Pro Arg Pro Gln Arg Ser Cys Ser Leu Asp Leu Gly Asp Ala Gly 
            580                 585                 590         


Cys Tyr Gly Tyr Ala Arg Arg Leu Gly Gly Ala Trp Ala Arg Arg Ser 
        595                 600                 605             


His Ser Val His Gly Gly Leu Leu Gly Ala Gly Cys Arg Gly Val Gly 
    610                 615                 620                 


Gly Ser Ala Glu Arg Leu Glu Glu Ser Val Val 
625                 630                 635 


<210>  7999
<211>  418
<212>  PRT
<213>  Homo Sapiens

<400>  7999

Met Ala Pro Pro Leu Leu Leu Leu Leu Leu Ala Ser Gly Ala Ala Ala 
1               5                   10                  15      


Cys Pro Leu Pro Cys Val Cys Gln Asn Leu Ser Glu Ser Leu Ser Thr 
            20                  25                  30          


Leu Cys Ala His Arg Gly Leu Leu Phe Val Pro Pro Asn Val Asp Arg 
        35                  40                  45              


Arg Thr Val Glu Leu Arg Leu Ala Asp Asn Phe Ile Gln Ala Leu Gly 
    50                  55                  60                  


Pro Pro Asp Phe Arg Asn Met Thr Gly Leu Val Asp Leu Thr Leu Ser 
65                  70                  75                  80  


Arg Asn Ala Ile Thr Arg Ile Gly Ala Arg Ala Phe Gly Asp Leu Glu 
                85                  90                  95      


Ser Leu Arg Ser Leu His Leu Asp Gly Asn Arg Leu Val Glu Leu Gly 
            100                 105                 110         


Thr Gly Ser Leu Arg Gly Pro Val Asn Leu Gln His Leu Ile Leu Ser 
        115                 120                 125             


Gly Asn Gln Leu Gly Arg Ile Ala Pro Gly Ala Phe Asp Asp Phe Leu 
    130                 135                 140                 


Glu Ser Leu Glu Asp Leu Asp Leu Ser Tyr Asn Asn Leu Arg Gln Val 
145                 150                 155                 160 


Pro Trp Ala Gly Ile Gly Ala Met Pro Ala Leu His Thr Leu Asn Leu 
                165                 170                 175     


Asp His Asn Leu Ile Asp Ala Leu Pro Pro Gly Ala Phe Ala Gln Leu 
            180                 185                 190         


Gly Gln Leu Ser Arg Leu Asp Leu Thr Ser Asn Arg Leu Ala Thr Leu 
        195                 200                 205             


Ala Pro Asp Pro Leu Phe Ser Arg Gly Arg Asp Ala Glu Ala Ser Pro 
    210                 215                 220                 


Ala Pro Leu Val Leu Ser Phe Ser Gly Asn Pro Leu His Cys Asn Cys 
225                 230                 235                 240 


Glu Leu Leu Trp Leu Arg Arg Leu Ala Arg Pro Asp Asp Leu Glu Thr 
                245                 250                 255     


Cys Ala Ser Pro Pro Gly Leu Ala Gly Arg Tyr Phe Trp Ala Val Pro 
            260                 265                 270         


Glu Gly Glu Phe Ser Cys Glu Pro Pro Leu Ile Ala Arg His Thr Gln 
        275                 280                 285             


Arg Leu Trp Val Leu Glu Gly Gln Arg Ala Thr Leu Arg Cys Arg Ala 
    290                 295                 300                 


Leu Gly Asp Pro Ala Pro Thr Met His Trp Val Gly Pro Asp Asp Arg 
305                 310                 315                 320 


Leu Val Gly Asn Ser Ser Arg Ala Arg Ala Phe Pro Asn Gly Thr Leu 
                325                 330                 335     


Glu Ile Gly Val Thr Gly Ala Gly Asp Ala Gly Gly Tyr Thr Cys Ile 
            340                 345                 350         


Ala Thr Asn Pro Ala Gly Glu Ala Thr Ala Arg Val Glu Leu Arg Val 
        355                 360                 365             


Leu Ala Leu Pro His Gly Gly Asn Ser Arg Pro Gly Ala Ala Ala Trp 
    370                 375                 380                 


Pro Gly Ser Pro Ser Leu Val Phe Ile Leu Ser Thr Ser Gly Ser Pro 
385                 390                 395                 400 


Val Tyr Leu Glu Gly Gln Gly Ala Leu Ser Ser Val Leu Ala Ser Arg 
                405                 410                 415     


Pro Gly 
        


<210>  8000
<211>  719
<212>  PRT
<213>  Homo Sapiens

<400>  8000

Met Glu Lys Ile Leu Phe Tyr Leu Phe Leu Ile Gly Ile Ala Val Lys 
1               5                   10                  15      


Ala Gln Ile Cys Pro Lys Arg Cys Val Cys Gln Ile Leu Ser Pro Asn 
            20                  25                  30          


Leu Ala Thr Leu Cys Ala Lys Lys Gly Leu Leu Phe Val Pro Pro Asn 
        35                  40                  45              


Ile Asp Arg Arg Thr Val Glu Leu Arg Leu Ala Asp Asn Phe Val Thr 
    50                  55                  60                  


Asn Ile Lys Arg Lys Asp Phe Ala Asn Met Thr Ser Leu Val Asp Leu 
65                  70                  75                  80  


Thr Leu Ser Arg Asn Thr Ile Ser Phe Ile Thr Pro His Ala Phe Ala 
                85                  90                  95      


Asp Leu Arg Asn Leu Arg Ala Leu His Leu Asn Ser Asn Arg Leu Thr 
            100                 105                 110         


Lys Ile Thr Asn Asp Met Phe Ser Gly Leu Ser Asn Leu His His Leu 
        115                 120                 125             


Ile Leu Asn Asn Asn Gln Leu Thr Leu Ile Ser Ser Thr Ala Phe Asp 
    130                 135                 140                 


Asp Val Phe Ala Leu Glu Glu Leu Asp Leu Ser Tyr Asn Asn Leu Glu 
145                 150                 155                 160 


Thr Ile Pro Trp Asp Ala Val Glu Lys Met Val Ser Leu His Thr Leu 
                165                 170                 175     


Ser Leu Asp His Asn Met Ile Asp Asn Ile Pro Lys Gly Thr Phe Ser 
            180                 185                 190         


His Leu His Lys Met Thr Arg Leu Asp Val Thr Ser Asn Lys Leu Gln 
        195                 200                 205             


Lys Leu Pro Pro Asp Pro Leu Phe Gln Arg Ala Gln Val Leu Ala Thr 
    210                 215                 220                 


Ser Gly Ile Ile Ser Pro Ser Thr Phe Ala Leu Ser Phe Gly Gly Asn 
225                 230                 235                 240 


Pro Leu His Cys Asn Cys Glu Leu Leu Trp Leu Arg Arg Leu Ser Arg 
                245                 250                 255     


Glu Asp Asp Leu Glu Thr Cys Ala Ser Pro Pro Leu Leu Thr Gly Arg 
            260                 265                 270         


Tyr Phe Trp Ser Ile Pro Glu Glu Glu Phe Leu Cys Glu Pro Pro Leu 
        275                 280                 285             


Ile Thr Arg His Thr His Glu Met Arg Val Leu Glu Gly Gln Arg Ala 
    290                 295                 300                 


Thr Leu Arg Cys Lys Ala Arg Gly Asp Pro Glu Pro Ala Ile His Trp 
305                 310                 315                 320 


Ile Ser Pro Glu Gly Lys Leu Ile Ser Asn Ala Thr Arg Ser Leu Val 
                325                 330                 335     


Tyr Asp Asn Gly Thr Leu Asp Ile Leu Ile Thr Thr Val Lys Asp Thr 
            340                 345                 350         


Gly Ala Phe Thr Cys Ile Ala Ser Asn Pro Ala Gly Glu Ala Thr Gln 
        355                 360                 365             


Ile Val Asp Leu His Ile Ile Lys Leu Pro His Leu Leu Asn Ser Thr 
    370                 375                 380                 


Asn His Ile His Glu Pro Asp Pro Gly Ser Ser Asp Ile Ser Thr Ser 
385                 390                 395                 400 


Thr Lys Ser Gly Ser Asn Thr Ser Ser Ser Asn Gly Asp Thr Lys Leu 
                405                 410                 415     


Ser Gln Asp Lys Ile Val Val Ala Glu Ala Thr Ser Ser Thr Ala Leu 
            420                 425                 430         


Leu Lys Phe Asn Phe Gln Arg Asn Ile Pro Gly Ile Arg Met Phe Gln 
        435                 440                 445             


Ile Gln Tyr Asn Gly Thr Tyr Asp Asp Thr Leu Val Tyr Arg Met Ile 
    450                 455                 460                 


Pro Pro Thr Ser Lys Thr Phe Leu Val Asn Asn Leu Ala Ala Gly Thr 
465                 470                 475                 480 


Met Tyr Asp Leu Cys Val Leu Ala Ile Tyr Asp Asp Gly Ile Thr Ser 
                485                 490                 495     


Leu Thr Ala Thr Arg Val Val Gly Cys Ile Gln Phe Thr Thr Glu Gln 
            500                 505                 510         


Asp Tyr Val Arg Cys His Phe Met Gln Ser Gln Phe Leu Gly Gly Thr 
        515                 520                 525             


Met Ile Ile Ile Ile Gly Gly Ile Ile Val Ala Ser Val Leu Val Phe 
    530                 535                 540                 


Ile Ile Ile Leu Met Ile Arg Tyr Lys Val Cys Asn Asn Asn Gly Gln 
545                 550                 555                 560 


His Lys Val Thr Lys Val Ser Asn Val Tyr Ser Gln Thr Asn Gly Ala 
                565                 570                 575     


Gln Ile Gln Gly Cys Ser Val Thr Leu Pro Gln Ser Val Ser Lys Gln 
            580                 585                 590         


Ala Val Gly His Glu Glu Asn Ala Gln Cys Cys Lys Ala Thr Ser Asp 
        595                 600                 605             


Asn Val Ile Gln Ser Ser Glu Thr Cys Ser Ser Gln Asp Ser Ser Thr 
    610                 615                 620                 


Thr Thr Ser Ala Leu Pro Pro Ser Trp Thr Ser Ser Thr Ser Val Ser 
625                 630                 635                 640 


Gln Lys Gln Lys Arg Lys Thr Gly Thr Lys Pro Ser Thr Glu Pro Gln 
                645                 650                 655     


Asn Glu Ala Val Thr Asn Val Glu Ser Gln Asn Thr Asn Arg Asn Asn 
            660                 665                 670         


Ser Thr Ala Leu Gln Leu Ala Ser Arg Pro Pro Asp Ser Val Thr Glu 
        675                 680                 685             


Gly Pro Thr Ser Lys Arg Ala His Ile Lys Pro Asn Ala Leu Leu Thr 
    690                 695                 700                 


Asn Val Asp Gln Ile Val Gln Glu Thr Gln Arg Leu Glu Leu Ile 
705                 710                 715                 


<210>  8001
<211>  466
<212>  PRT
<213>  Homo Sapiens

<400>  8001

Met Glu Lys Ile Leu Phe Tyr Leu Phe Leu Ile Gly Ile Ala Val Lys 
1               5                   10                  15      


Ala Gln Ile Cys Pro Lys Arg Cys Val Cys Gln Ile Leu Ser Pro Asn 
            20                  25                  30          


Leu Ala Thr Leu Cys Ala Lys Lys Gly Leu Leu Phe Val Pro Pro Asn 
        35                  40                  45              


Ile Asp Arg Arg Thr Val Glu Leu Arg Leu Ala Asp Asn Phe Val Thr 
    50                  55                  60                  


Asn Ile Lys Arg Lys Asp Phe Ala Asn Met Thr Ser Leu Val Asp Leu 
65                  70                  75                  80  


Thr Leu Ser Arg Asn Thr Ile Ser Phe Ile Thr Pro His Ala Phe Ala 
                85                  90                  95      


Asp Leu Arg Asn Leu Arg Ala Leu His Leu Asn Ser Asn Arg Leu Thr 
            100                 105                 110         


Lys Ile Thr Asn Asp Met Phe Ser Gly Leu Ser Asn Leu His His Leu 
        115                 120                 125             


Ile Leu Asn Asn Asn Gln Leu Thr Leu Ile Ser Ser Thr Ala Phe Asp 
    130                 135                 140                 


Asp Val Phe Ala Leu Glu Glu Leu Asp Leu Ser Tyr Asn Asn Leu Glu 
145                 150                 155                 160 


Thr Ile Pro Trp Asp Ala Val Glu Lys Met Val Ser Leu His Thr Leu 
                165                 170                 175     


Ser Leu Asp His Asn Met Ile Asp Asn Ile Pro Lys Gly Thr Phe Ser 
            180                 185                 190         


His Leu His Lys Met Thr Arg Leu Asp Val Thr Ser Asn Lys Leu Gln 
        195                 200                 205             


Lys Leu Pro Pro Asp Pro Leu Phe Gln Arg Ala Gln Val Leu Ala Thr 
    210                 215                 220                 


Ser Gly Ile Ile Ser Pro Ser Thr Phe Ala Leu Ser Phe Gly Gly Asn 
225                 230                 235                 240 


Pro Leu His Cys Asn Cys Glu Leu Leu Trp Leu Arg Arg Leu Ser Arg 
                245                 250                 255     


Glu Asp Asp Leu Glu Thr Cys Ala Ser Pro Pro Leu Leu Thr Gly Arg 
            260                 265                 270         


Tyr Phe Trp Ser Ile Pro Glu Glu Glu Phe Leu Cys Glu Pro Pro Leu 
        275                 280                 285             


Ile Thr Arg His Thr His Glu Met Arg Val Leu Glu Gly Gln Arg Ala 
    290                 295                 300                 


Thr Leu Arg Cys Lys Ala Arg Gly Asp Pro Glu Pro Ala Ile His Trp 
305                 310                 315                 320 


Ile Ser Pro Glu Gly Lys Leu Ile Ser Asn Ala Thr Arg Ser Leu Val 
                325                 330                 335     


Tyr Asp Asn Gly Thr Leu Asp Ile Leu Ile Thr Thr Val Lys Asp Thr 
            340                 345                 350         


Gly Ala Phe Thr Cys Ile Ala Ser Asn Pro Ala Gly Glu Ala Thr Gln 
        355                 360                 365             


Ile Val Asp Leu His Ile Ile Lys Leu Pro His Leu Leu Asn Ser Thr 
    370                 375                 380                 


Asn His Ile His Glu Pro Asp Pro Gly Ser Ser Asp Ile Ser Thr Ser 
385                 390                 395                 400 


Thr Lys Ser Gly Ser Asn Thr Ser Ser Ser Asn Gly Asp Thr Lys Leu 
                405                 410                 415     


Ser Gln Asp Lys Ile Val Val Ala Glu Ala Thr Ser Ser Thr Ala Leu 
            420                 425                 430         


Leu Lys Phe Asn Phe Gln Arg Asn Ile Pro Gly Ile Arg Met Phe Gln 
        435                 440                 445             


Ile Gln Tyr Asn Gly Thr Tyr Asp Asp Thr Leu Val Tyr Arg Cys Phe 
    450                 455                 460                 


Ala Asp 
465     


<210>  8002
<211>  465
<212>  PRT
<213>  Homo Sapiens

<400>  8002

Met Glu Lys Ile Leu Phe Tyr Leu Phe Leu Ile Gly Ile Ala Val Lys 
1               5                   10                  15      


Ala Gln Ile Cys Pro Lys Arg Cys Val Cys Gln Ile Leu Ser Pro Asn 
            20                  25                  30          


Leu Ala Thr Leu Cys Ala Lys Lys Gly Leu Leu Phe Val Pro Pro Asn 
        35                  40                  45              


Ile Asp Arg Arg Thr Val Glu Leu Arg Leu Ala Asp Asn Phe Val Thr 
    50                  55                  60                  


Asn Ile Lys Arg Lys Asp Phe Ala Asn Met Thr Ser Leu Val Asp Leu 
65                  70                  75                  80  


Thr Leu Ser Arg Asn Thr Ile Ser Phe Ile Thr Pro His Ala Phe Ala 
                85                  90                  95      


Asp Leu Arg Asn Leu Arg Ala Leu His Leu Asn Ser Asn Arg Leu Thr 
            100                 105                 110         


Lys Ile Thr Asn Asp Met Phe Ser Gly Leu Ser Asn Leu His His Leu 
        115                 120                 125             


Ile Leu Asn Asn Asn Gln Leu Thr Leu Ile Ser Ser Thr Ala Phe Asp 
    130                 135                 140                 


Asp Val Phe Ala Leu Glu Glu Leu Asp Leu Ser Tyr Asn Asn Leu Glu 
145                 150                 155                 160 


Thr Ile Pro Trp Asp Ala Val Glu Lys Met Val Ser Leu His Thr Leu 
                165                 170                 175     


Ser Leu Asp His Asn Met Ile Asp Asn Ile Pro Lys Gly Thr Phe Ser 
            180                 185                 190         


His Leu His Lys Met Thr Arg Leu Asp Val Thr Ser Asn Lys Leu Gln 
        195                 200                 205             


Lys Leu Pro Pro Asp Pro Leu Phe Gln Arg Ala Gln Val Leu Ala Thr 
    210                 215                 220                 


Ser Gly Ile Ile Ser Pro Ser Thr Phe Ala Leu Ser Phe Gly Gly Asn 
225                 230                 235                 240 


Pro Leu His Cys Asn Cys Glu Leu Leu Trp Leu Arg Arg Leu Ser Arg 
                245                 250                 255     


Glu Asp Asp Leu Glu Thr Cys Ala Ser Pro Pro Leu Leu Thr Gly Arg 
            260                 265                 270         


Tyr Phe Trp Ser Ile Pro Glu Glu Glu Phe Leu Cys Glu Pro Pro Leu 
        275                 280                 285             


Ile Thr Arg His Thr His Glu Met Arg Val Leu Glu Gly Gln Arg Ala 
    290                 295                 300                 


Thr Leu Arg Cys Lys Ala Arg Gly Asp Pro Glu Pro Ala Ile His Trp 
305                 310                 315                 320 


Ile Ser Pro Glu Gly Lys Leu Ile Ser Asn Ala Thr Arg Ser Leu Val 
                325                 330                 335     


Tyr Asp Asn Gly Thr Leu Asp Ile Leu Ile Thr Thr Val Lys Asp Thr 
            340                 345                 350         


Gly Ala Phe Thr Cys Ile Ala Ser Asn Pro Ala Gly Glu Ala Thr Gln 
        355                 360                 365             


Ile Val Asp Leu His Ile Ile Lys Leu Pro His Leu Leu Asn Ser Thr 
    370                 375                 380                 


Asn His Ile His Glu Pro Asp Pro Gly Ser Ser Asp Ile Ser Thr Ser 
385                 390                 395                 400 


Thr Lys Ser Gly Ser Asn Thr Ser Ser Ser Asn Gly Asp Thr Lys Leu 
                405                 410                 415     


Ser Gln Asp Lys Ile Val Val Ala Glu Ala Thr Ser Ser Thr Ala Leu 
            420                 425                 430         


Leu Lys Phe Asn Phe Gln Arg Asn Ile Pro Gly Ile Arg Met Phe Gln 
        435                 440                 445             


Ile Gln Tyr Asn Gly Thr Tyr Asp Asp Thr Leu Val Tyr Arg Gly Trp 
    450                 455                 460                 


Ser 
465 


<210>  8003
<211>  347
<212>  PRT
<213>  Homo Sapiens

<400>  8003

Met Ser Ser Trp Ser Arg Gln Arg Pro Lys Ser Pro Gly Gly Ile Gln 
1               5                   10                  15      


Pro His Val Ser Arg Thr Leu Phe Leu Leu Leu Leu Leu Ala Ala Ser 
            20                  25                  30          


Ala Trp Gly Val Thr Leu Ser Pro Lys Asp Cys Gln Val Phe Arg Ser 
        35                  40                  45              


Asp His Gly Ser Ser Ile Ser Cys Gln Pro Pro Ala Glu Ile Pro Gly 
    50                  55                  60                  


Tyr Leu Pro Ala Asp Thr Val His Leu Ala Val Glu Phe Phe Asn Leu 
65                  70                  75                  80  


Thr His Leu Pro Ala Asn Leu Leu Gln Gly Ala Ser Lys Leu Gln Glu 
                85                  90                  95      


Leu His Leu Ser Ser Asn Gly Leu Glu Ser Leu Ser Pro Glu Phe Leu 
            100                 105                 110         


Arg Pro Val Pro Gln Leu Arg Val Leu Asp Leu Thr Arg Asn Ala Leu 
        115                 120                 125             


Thr Gly Leu Pro Pro Gly Leu Phe Gln Ala Ser Ala Thr Leu Asp Thr 
    130                 135                 140                 


Leu Val Leu Lys Glu Asn Gln Leu Glu Val Leu Glu Val Ser Trp Leu 
145                 150                 155                 160 


His Gly Leu Lys Ala Leu Gly His Leu Asp Leu Ser Gly Asn Arg Leu 
                165                 170                 175     


Arg Lys Leu Pro Pro Gly Leu Leu Ala Asn Phe Thr Leu Leu Arg Thr 
            180                 185                 190         


Leu Asp Leu Gly Glu Asn Gln Leu Glu Thr Leu Pro Pro Asp Leu Leu 
        195                 200                 205             


Arg Gly Pro Leu Gln Leu Glu Arg Leu His Leu Glu Gly Asn Lys Leu 
    210                 215                 220                 


Gln Val Leu Gly Lys Asp Leu Leu Leu Pro Gln Pro Asp Leu Arg Tyr 
225                 230                 235                 240 


Leu Phe Leu Asn Gly Asn Lys Leu Ala Arg Val Ala Ala Gly Ala Phe 
                245                 250                 255     


Gln Gly Leu Arg Gln Leu Asp Met Leu Asp Leu Ser Asn Asn Ser Leu 
            260                 265                 270         


Ala Ser Val Pro Glu Gly Leu Trp Ala Ser Leu Gly Gln Pro Asn Trp 
        275                 280                 285             


Asp Met Arg Asp Gly Phe Asp Ile Ser Gly Asn Pro Trp Ile Cys Asp 
    290                 295                 300                 


Gln Asn Leu Ser Asp Leu Tyr Arg Trp Leu Gln Ala Gln Lys Asp Lys 
305                 310                 315                 320 


Met Phe Ser Gln Asn Asp Thr Arg Cys Ala Gly Pro Glu Ala Val Lys 
                325                 330                 335     


Gly Gln Thr Leu Leu Ala Val Ala Lys Ser Gln 
            340                 345         


<210>  8004
<211>  4544
<212>  PRT
<213>  Homo Sapiens

<400>  8004

Met Leu Thr Pro Pro Leu Leu Leu Leu Leu Pro Leu Leu Ser Ala Leu 
1               5                   10                  15      


Val Ala Ala Ala Ile Asp Ala Pro Lys Thr Cys Ser Pro Lys Gln Phe 
            20                  25                  30          


Ala Cys Arg Asp Gln Ile Thr Cys Ile Ser Lys Gly Trp Arg Cys Asp 
        35                  40                  45              


Gly Glu Arg Asp Cys Pro Asp Gly Ser Asp Glu Ala Pro Glu Ile Cys 
    50                  55                  60                  


Pro Gln Ser Lys Ala Gln Arg Cys Gln Pro Asn Glu His Asn Cys Leu 
65                  70                  75                  80  


Gly Thr Glu Leu Cys Val Pro Met Ser Arg Leu Cys Asn Gly Val Gln 
                85                  90                  95      


Asp Cys Met Asp Gly Ser Asp Glu Gly Pro His Cys Arg Glu Leu Gln 
            100                 105                 110         


Gly Asn Cys Ser Arg Leu Gly Cys Gln His His Cys Val Pro Thr Leu 
        115                 120                 125             


Asp Gly Pro Thr Cys Tyr Cys Asn Ser Ser Phe Gln Leu Gln Ala Asp 
    130                 135                 140                 


Gly Lys Thr Cys Lys Asp Phe Asp Glu Cys Ser Val Tyr Gly Thr Cys 
145                 150                 155                 160 


Ser Gln Leu Cys Thr Asn Thr Asp Gly Ser Phe Ile Cys Gly Cys Val 
                165                 170                 175     


Glu Gly Tyr Leu Leu Gln Pro Asp Asn Arg Ser Cys Lys Ala Lys Asn 
            180                 185                 190         


Glu Pro Val Asp Arg Pro Pro Val Leu Leu Ile Ala Asn Ser Gln Asn 
        195                 200                 205             


Ile Leu Ala Thr Tyr Leu Ser Gly Ala Gln Val Ser Thr Ile Thr Pro 
    210                 215                 220                 


Thr Ser Thr Arg Gln Thr Thr Ala Met Asp Phe Ser Tyr Ala Asn Glu 
225                 230                 235                 240 


Thr Val Cys Trp Val His Val Gly Asp Ser Ala Ala Gln Thr Gln Leu 
                245                 250                 255     


Lys Cys Ala Arg Met Pro Gly Leu Lys Gly Phe Val Asp Glu His Thr 
            260                 265                 270         


Ile Asn Ile Ser Leu Ser Leu His His Val Glu Gln Met Ala Ile Asp 
        275                 280                 285             


Trp Leu Thr Gly Asn Phe Tyr Phe Val Asp Asp Ile Asp Asp Arg Ile 
    290                 295                 300                 


Phe Val Cys Asn Arg Asn Gly Asp Thr Cys Val Thr Leu Leu Asp Leu 
305                 310                 315                 320 


Glu Leu Tyr Asn Pro Lys Gly Ile Ala Leu Asp Pro Ala Met Gly Lys 
                325                 330                 335     


Val Phe Phe Thr Asp Tyr Gly Gln Ile Pro Lys Val Glu Arg Cys Asp 
            340                 345                 350         


Met Asp Gly Gln Asn Arg Thr Lys Leu Val Asp Ser Lys Ile Val Phe 
        355                 360                 365             


Pro His Gly Ile Thr Leu Asp Leu Val Ser Arg Leu Val Tyr Trp Ala 
    370                 375                 380                 


Asp Ala Tyr Leu Asp Tyr Ile Glu Val Val Asp Tyr Glu Gly Lys Gly 
385                 390                 395                 400 


Arg Gln Thr Ile Ile Gln Gly Ile Leu Ile Glu His Leu Tyr Gly Leu 
                405                 410                 415     


Thr Val Phe Glu Asn Tyr Leu Tyr Ala Thr Asn Ser Asp Asn Ala Asn 
            420                 425                 430         


Ala Gln Gln Lys Thr Ser Val Ile Arg Val Asn Arg Phe Asn Ser Thr 
        435                 440                 445             


Glu Tyr Gln Val Val Thr Arg Val Asp Lys Gly Gly Ala Leu His Ile 
    450                 455                 460                 


Tyr His Gln Arg Arg Gln Pro Arg Val Arg Ser His Ala Cys Glu Asn 
465                 470                 475                 480 


Asp Gln Tyr Gly Lys Pro Gly Gly Cys Ser Asp Ile Cys Leu Leu Ala 
                485                 490                 495     


Asn Ser His Lys Ala Arg Thr Cys Arg Cys Arg Ser Gly Phe Ser Leu 
            500                 505                 510         


Gly Ser Asp Gly Lys Ser Cys Lys Lys Pro Glu His Glu Leu Phe Leu 
        515                 520                 525             


Val Tyr Gly Lys Gly Arg Pro Gly Ile Ile Arg Gly Met Asp Met Gly 
    530                 535                 540                 


Ala Lys Val Pro Asp Glu His Met Ile Pro Ile Glu Asn Leu Met Asn 
545                 550                 555                 560 


Pro Arg Ala Leu Asp Phe His Ala Glu Thr Gly Phe Ile Tyr Phe Ala 
                565                 570                 575     


Asp Thr Thr Ser Tyr Leu Ile Gly Arg Gln Lys Ile Asp Gly Thr Glu 
            580                 585                 590         


Arg Glu Thr Ile Leu Lys Asp Gly Ile His Asn Val Glu Gly Val Ala 
        595                 600                 605             


Val Asp Trp Met Gly Asp Asn Leu Tyr Trp Thr Asp Asp Gly Pro Lys 
    610                 615                 620                 


Lys Thr Ile Ser Val Ala Arg Leu Glu Lys Ala Ala Gln Thr Arg Lys 
625                 630                 635                 640 


Thr Leu Ile Glu Gly Lys Met Thr His Pro Arg Ala Ile Val Val Asp 
                645                 650                 655     


Pro Leu Asn Gly Trp Met Tyr Trp Thr Asp Trp Glu Glu Asp Pro Lys 
            660                 665                 670         


Asp Ser Arg Arg Gly Arg Leu Glu Arg Ala Trp Met Asp Gly Ser His 
        675                 680                 685             


Arg Asp Ile Phe Val Thr Ser Lys Thr Val Leu Trp Pro Asn Gly Leu 
    690                 695                 700                 


Ser Leu Asp Ile Pro Ala Gly Arg Leu Tyr Trp Val Asp Ala Phe Tyr 
705                 710                 715                 720 


Asp Arg Ile Glu Thr Ile Leu Leu Asn Gly Thr Asp Arg Lys Ile Val 
                725                 730                 735     


Tyr Glu Gly Pro Glu Leu Asn His Ala Phe Gly Leu Cys His His Gly 
            740                 745                 750         


Asn Tyr Leu Phe Trp Thr Glu Tyr Arg Ser Gly Ser Val Tyr Arg Leu 
        755                 760                 765             


Glu Arg Gly Val Gly Gly Ala Pro Pro Thr Val Thr Leu Leu Arg Ser 
    770                 775                 780                 


Glu Arg Pro Pro Ile Phe Glu Ile Arg Met Tyr Asp Ala Gln Gln Gln 
785                 790                 795                 800 


Gln Val Gly Thr Asn Lys Cys Arg Val Asn Asn Gly Gly Cys Ser Ser 
                805                 810                 815     


Leu Cys Leu Ala Thr Pro Gly Ser Arg Gln Cys Ala Cys Ala Glu Asp 
            820                 825                 830         


Gln Val Leu Asp Ala Asp Gly Val Thr Cys Leu Ala Asn Pro Ser Tyr 
        835                 840                 845             


Val Pro Pro Pro Gln Cys Gln Pro Gly Glu Phe Ala Cys Ala Asn Ser 
    850                 855                 860                 


Arg Cys Ile Gln Glu Arg Trp Lys Cys Asp Gly Asp Asn Asp Cys Leu 
865                 870                 875                 880 


Asp Asn Ser Asp Glu Ala Pro Ala Leu Cys His Gln His Thr Cys Pro 
                885                 890                 895     


Ser Asp Arg Phe Lys Cys Glu Asn Asn Arg Cys Ile Pro Asn Arg Trp 
            900                 905                 910         


Leu Cys Asp Gly Asp Asn Asp Cys Gly Asn Ser Glu Asp Glu Ser Asn 
        915                 920                 925             


Ala Thr Cys Ser Ala Arg Thr Cys Pro Pro Asn Gln Phe Ser Cys Ala 
    930                 935                 940                 


Ser Gly Arg Cys Ile Pro Ile Ser Trp Thr Cys Asp Leu Asp Asp Asp 
945                 950                 955                 960 


Cys Gly Asp Arg Ser Asp Glu Ser Ala Ser Cys Ala Tyr Pro Thr Cys 
                965                 970                 975     


Phe Pro Leu Thr Gln Phe Thr Cys Asn Asn Gly Arg Cys Ile Asn Ile 
            980                 985                 990         


Asn Trp Arg Cys Asp Asn Asp Asn  Asp Cys Gly Asp Asn  Ser Asp Glu 
        995                 1000                 1005             


Ala Gly  Cys Ser His Ser Cys  Ser Ser Thr Gln Phe  Lys Cys Asn 
    1010                 1015                 1020             


Ser Gly  Arg Cys Ile Pro Glu  His Trp Thr Cys Asp  Gly Asp Asn 
    1025                 1030                 1035             


Asp Cys  Gly Asp Tyr Ser Asp  Glu Thr His Ala Asn  Cys Thr Asn 
    1040                 1045                 1050             


Gln Ala  Thr Arg Pro Pro Gly  Gly Cys His Thr Asp  Glu Phe Gln 
    1055                 1060                 1065             


Cys Arg  Leu Asp Gly Leu Cys  Ile Pro Leu Arg Trp  Arg Cys Asp 
    1070                 1075                 1080             


Gly Asp  Thr Asp Cys Met Asp  Ser Ser Asp Glu Lys  Ser Cys Glu 
    1085                 1090                 1095             


Gly Val  Thr His Val Cys Asp  Pro Ser Val Lys Phe  Gly Cys Lys 
    1100                 1105                 1110             


Asp Ser  Ala Arg Cys Ile Ser  Lys Ala Trp Val Cys  Asp Gly Asp 
    1115                 1120                 1125             


Asn Asp  Cys Glu Asp Asn Ser  Asp Glu Glu Asn Cys  Glu Ser Leu 
    1130                 1135                 1140             


Ala Cys  Arg Pro Pro Ser His  Pro Cys Ala Asn Asn  Thr Ser Val 
    1145                 1150                 1155             


Cys Leu  Pro Pro Asp Lys Leu  Cys Asp Gly Asn Asp  Asp Cys Gly 
    1160                 1165                 1170             


Asp Gly  Ser Asp Glu Gly Glu  Leu Cys Asp Gln Cys  Ser Leu Asn 
    1175                 1180                 1185             


Asn Gly  Gly Cys Ser His Asn  Cys Ser Val Ala Pro  Gly Glu Gly 
    1190                 1195                 1200             


Ile Val  Cys Ser Cys Pro Leu  Gly Met Glu Leu Gly  Pro Asp Asn 
    1205                 1210                 1215             


His Thr  Cys Gln Ile Gln Ser  Tyr Cys Ala Lys His  Leu Lys Cys 
    1220                 1225                 1230             


Ser Gln  Lys Cys Asp Gln Asn  Lys Phe Ser Val Lys  Cys Ser Cys 
    1235                 1240                 1245             


Tyr Glu  Gly Trp Val Leu Glu  Pro Asp Gly Glu Ser  Cys Arg Ser 
    1250                 1255                 1260             


Leu Asp  Pro Phe Lys Pro Phe  Ile Ile Phe Ser Asn  Arg His Glu 
    1265                 1270                 1275             


Ile Arg  Arg Ile Asp Leu His  Lys Gly Asp Tyr Ser  Val Leu Val 
    1280                 1285                 1290             


Pro Gly  Leu Arg Asn Thr Ile  Ala Leu Asp Phe His  Leu Ser Gln 
    1295                 1300                 1305             


Ser Ala  Leu Tyr Trp Thr Asp  Val Val Glu Asp Lys  Ile Tyr Arg 
    1310                 1315                 1320             


Gly Lys  Leu Leu Asp Asn Gly  Ala Leu Thr Ser Phe  Glu Val Val 
    1325                 1330                 1335             


Ile Gln  Tyr Gly Leu Ala Thr  Pro Glu Gly Leu Ala  Val Asp Trp 
    1340                 1345                 1350             


Ile Ala  Gly Asn Ile Tyr Trp  Val Glu Ser Asn Leu  Asp Gln Ile 
    1355                 1360                 1365             


Glu Val  Ala Lys Leu Asp Gly  Thr Leu Arg Thr Thr  Leu Leu Ala 
    1370                 1375                 1380             


Gly Asp  Ile Glu His Pro Arg  Ala Ile Ala Leu Asp  Pro Arg Asp 
    1385                 1390                 1395             


Gly Ile  Leu Phe Trp Thr Asp  Trp Asp Ala Ser Leu  Pro Arg Ile 
    1400                 1405                 1410             


Glu Ala  Ala Ser Met Ser Gly  Ala Gly Arg Arg Thr  Val His Arg 
    1415                 1420                 1425             


Glu Thr  Gly Ser Gly Gly Trp  Pro Asn Gly Leu Thr  Val Asp Tyr 
    1430                 1435                 1440             


Leu Glu  Lys Arg Ile Leu Trp  Ile Asp Ala Arg Ser  Asp Ala Ile 
    1445                 1450                 1455             


Tyr Ser  Ala Arg Tyr Asp Gly  Ser Gly His Met Glu  Val Leu Arg 
    1460                 1465                 1470             


Gly His  Glu Phe Leu Ser His  Pro Phe Ala Val Thr  Leu Tyr Gly 
    1475                 1480                 1485             


Gly Glu  Val Tyr Trp Thr Asp  Trp Arg Thr Asn Thr  Leu Ala Lys 
    1490                 1495                 1500             


Ala Asn  Lys Trp Thr Gly His  Asn Val Thr Val Val  Gln Arg Thr 
    1505                 1510                 1515             


Asn Thr  Gln Pro Phe Asp Leu  Gln Val Tyr His Pro  Ser Arg Gln 
    1520                 1525                 1530             


Pro Met  Ala Pro Asn Pro Cys  Glu Ala Asn Gly Gly  Gln Gly Pro 
    1535                 1540                 1545             


Cys Ser  His Leu Cys Leu Ile  Asn Tyr Asn Arg Thr  Val Ser Cys 
    1550                 1555                 1560             


Ala Cys  Pro His Leu Met Lys  Leu His Lys Asp Asn  Thr Thr Cys 
    1565                 1570                 1575             


Tyr Glu  Phe Lys Lys Phe Leu  Leu Tyr Ala Arg Gln  Met Glu Ile 
    1580                 1585                 1590             


Arg Gly  Val Asp Leu Asp Ala  Pro Tyr Tyr Asn Tyr  Ile Ile Ser 
    1595                 1600                 1605             


Phe Thr  Val Pro Asp Ile Asp  Asn Val Thr Val Leu  Asp Tyr Asp 
    1610                 1615                 1620             


Ala Arg  Glu Gln Arg Val Tyr  Trp Ser Asp Val Arg  Thr Gln Ala 
    1625                 1630                 1635             


Ile Lys  Arg Ala Phe Ile Asn  Gly Thr Gly Val Glu  Thr Val Val 
    1640                 1645                 1650             


Ser Ala  Asp Leu Pro Asn Ala  His Gly Leu Ala Val  Asp Trp Val 
    1655                 1660                 1665             


Ser Arg  Asn Leu Phe Trp Thr  Ser Tyr Asp Thr Asn  Lys Lys Gln 
    1670                 1675                 1680             


Ile Asn  Val Ala Arg Leu Asp  Gly Ser Phe Lys Asn  Ala Val Val 
    1685                 1690                 1695             


Gln Gly  Leu Glu Gln Pro His  Gly Leu Val Val His  Pro Leu Arg 
    1700                 1705                 1710             


Gly Lys  Leu Tyr Trp Thr Asp  Gly Asp Asn Ile Ser  Met Ala Asn 
    1715                 1720                 1725             


Met Asp  Gly Ser Asn Arg Thr  Leu Leu Phe Ser Gly  Gln Lys Gly 
    1730                 1735                 1740             


Pro Val  Gly Leu Ala Ile Asp  Phe Pro Glu Ser Lys  Leu Tyr Trp 
    1745                 1750                 1755             


Ile Ser  Ser Gly Asn His Thr  Ile Asn Arg Cys Asn  Leu Asp Gly 
    1760                 1765                 1770             


Ser Gly  Leu Glu Val Ile Asp  Ala Met Arg Ser Gln  Leu Gly Lys 
    1775                 1780                 1785             


Ala Thr  Ala Leu Ala Ile Met  Gly Asp Lys Leu Trp  Trp Ala Asp 
    1790                 1795                 1800             


Gln Val  Ser Glu Lys Met Gly  Thr Cys Ser Lys Ala  Asp Gly Ser 
    1805                 1810                 1815             


Gly Ser  Val Val Leu Arg Asn  Ser Thr Thr Leu Val  Met His Met 
    1820                 1825                 1830             


Lys Val  Tyr Asp Glu Ser Ile  Gln Leu Asp His Lys  Gly Thr Asn 
    1835                 1840                 1845             


Pro Cys  Ser Val Asn Asn Gly  Asp Cys Ser Gln Leu  Cys Leu Pro 
    1850                 1855                 1860             


Thr Ser  Glu Thr Thr Arg Ser  Cys Met Cys Thr Ala  Gly Tyr Ser 
    1865                 1870                 1875             


Leu Arg  Ser Gly Gln Gln Ala  Cys Glu Gly Val Gly  Ser Phe Leu 
    1880                 1885                 1890             


Leu Tyr  Ser Val His Glu Gly  Ile Arg Gly Ile Pro  Leu Asp Pro 
    1895                 1900                 1905             


Asn Asp  Lys Ser Asp Ala Leu  Val Pro Val Ser Gly  Thr Ser Leu 
    1910                 1915                 1920             


Ala Val  Gly Ile Asp Phe His  Ala Glu Asn Asp Thr  Ile Tyr Trp 
    1925                 1930                 1935             


Val Asp  Met Gly Leu Ser Thr  Ile Ser Arg Ala Lys  Arg Asp Gln 
    1940                 1945                 1950             


Thr Trp  Arg Glu Asp Val Val  Thr Asn Gly Ile Gly  Arg Val Glu 
    1955                 1960                 1965             


Gly Ile  Ala Val Asp Trp Ile  Ala Gly Asn Ile Tyr  Trp Thr Asp 
    1970                 1975                 1980             


Gln Gly  Phe Asp Val Ile Glu  Val Ala Arg Leu Asn  Gly Ser Phe 
    1985                 1990                 1995             


Arg Tyr  Val Val Ile Ser Gln  Gly Leu Asp Lys Pro  Arg Ala Ile 
    2000                 2005                 2010             


Thr Val  His Pro Glu Lys Gly  Tyr Leu Phe Trp Thr  Glu Trp Gly 
    2015                 2020                 2025             


Gln Tyr  Pro Arg Ile Glu Arg  Ser Arg Leu Asp Gly  Thr Glu Arg 
    2030                 2035                 2040             


Val Val  Leu Val Asn Val Ser  Ile Ser Trp Pro Asn  Gly Ile Ser 
    2045                 2050                 2055             


Val Asp  Tyr Gln Asp Gly Lys  Leu Tyr Trp Cys Asp  Ala Arg Thr 
    2060                 2065                 2070             


Asp Lys  Ile Glu Arg Ile Asp  Leu Glu Thr Gly Glu  Asn Arg Glu 
    2075                 2080                 2085             


Val Val  Leu Ser Ser Asn Asn  Met Asp Met Phe Ser  Val Ser Val 
    2090                 2095                 2100             


Phe Glu  Asp Phe Ile Tyr Trp  Ser Asp Arg Thr His  Ala Asn Gly 
    2105                 2110                 2115             


Ser Ile  Lys Arg Gly Ser Lys  Asp Asn Ala Thr Asp  Ser Val Pro 
    2120                 2125                 2130             


Leu Arg  Thr Gly Ile Gly Val  Gln Leu Lys Asp Ile  Lys Val Phe 
    2135                 2140                 2145             


Asn Arg  Asp Arg Gln Lys Gly  Thr Asn Val Cys Ala  Val Ala Asn 
    2150                 2155                 2160             


Gly Gly  Cys Gln Gln Leu Cys  Leu Tyr Arg Gly Arg  Gly Gln Arg 
    2165                 2170                 2175             


Ala Cys  Ala Cys Ala His Gly  Met Leu Ala Glu Asp  Gly Ala Ser 
    2180                 2185                 2190             


Cys Arg  Glu Tyr Ala Gly Tyr  Leu Leu Tyr Ser Glu  Arg Thr Ile 
    2195                 2200                 2205             


Leu Lys  Ser Ile His Leu Ser  Asp Glu Arg Asn Leu  Asn Ala Pro 
    2210                 2215                 2220             


Val Gln  Pro Phe Glu Asp Pro  Glu His Met Lys Asn  Val Ile Ala 
    2225                 2230                 2235             


Leu Ala  Phe Asp Tyr Arg Ala  Gly Thr Ser Pro Gly  Thr Pro Asn 
    2240                 2245                 2250             


Arg Ile  Phe Phe Ser Asp Ile  His Phe Gly Asn Ile  Gln Gln Ile 
    2255                 2260                 2265             


Asn Asp  Asp Gly Ser Arg Arg  Ile Thr Ile Val Glu  Asn Val Gly 
    2270                 2275                 2280             


Ser Val  Glu Gly Leu Ala Tyr  His Arg Gly Trp Asp  Thr Leu Tyr 
    2285                 2290                 2295             


Trp Thr  Ser Tyr Thr Thr Ser  Thr Ile Thr Arg His  Thr Val Asp 
    2300                 2305                 2310             


Gln Thr  Arg Pro Gly Ala Phe  Glu Arg Glu Thr Val  Ile Thr Met 
    2315                 2320                 2325             


Ser Gly  Asp Asp His Pro Arg  Ala Phe Val Leu Asp  Glu Cys Gln 
    2330                 2335                 2340             


Asn Leu  Met Phe Trp Thr Asn  Trp Asn Glu Gln His  Pro Ser Ile 
    2345                 2350                 2355             


Met Arg  Ala Ala Leu Ser Gly  Ala Asn Val Leu Thr  Leu Ile Glu 
    2360                 2365                 2370             


Lys Asp  Ile Arg Thr Pro Asn  Gly Leu Ala Ile Asp  His Arg Ala 
    2375                 2380                 2385             


Glu Lys  Leu Tyr Phe Ser Asp  Ala Thr Leu Asp Lys  Ile Glu Arg 
    2390                 2395                 2400             


Cys Glu  Tyr Asp Gly Ser His  Arg Tyr Val Ile Leu  Lys Ser Glu 
    2405                 2410                 2415             


Pro Val  His Pro Phe Gly Leu  Ala Val Tyr Gly Glu  His Ile Phe 
    2420                 2425                 2430             


Trp Thr  Asp Trp Val Arg Arg  Ala Val Gln Arg Ala  Asn Lys His 
    2435                 2440                 2445             


Val Gly  Ser Asn Met Lys Leu  Leu Arg Val Asp Ile  Pro Gln Gln 
    2450                 2455                 2460             


Pro Met  Gly Ile Ile Ala Val  Ala Asn Asp Thr Asn  Ser Cys Glu 
    2465                 2470                 2475             


Leu Ser  Pro Cys Arg Ile Asn  Asn Gly Gly Cys Gln  Asp Leu Cys 
    2480                 2485                 2490             


Leu Leu  Thr His Gln Gly His  Val Asn Cys Ser Cys  Arg Gly Gly 
    2495                 2500                 2505             


Arg Ile  Leu Gln Asp Asp Leu  Thr Cys Arg Ala Val  Asn Ser Ser 
    2510                 2515                 2520             


Cys Arg  Ala Gln Asp Glu Phe  Glu Cys Ala Asn Gly  Glu Cys Ile 
    2525                 2530                 2535             


Asn Phe  Ser Leu Thr Cys Asp  Gly Val Pro His Cys  Lys Asp Lys 
    2540                 2545                 2550             


Ser Asp  Glu Lys Pro Ser Tyr  Cys Asn Ser Arg Arg  Cys Lys Lys 
    2555                 2560                 2565             


Thr Phe  Arg Gln Cys Ser Asn  Gly Arg Cys Val Ser  Asn Met Leu 
    2570                 2575                 2580             


Trp Cys  Asn Gly Ala Asp Asp  Cys Gly Asp Gly Ser  Asp Glu Ile 
    2585                 2590                 2595             


Pro Cys  Asn Lys Thr Ala Cys  Gly Val Gly Glu Phe  Arg Cys Arg 
    2600                 2605                 2610             


Asp Gly  Thr Cys Ile Gly Asn  Ser Ser Arg Cys Asn  Gln Phe Val 
    2615                 2620                 2625             


Asp Cys  Glu Asp Ala Ser Asp  Glu Met Asn Cys Ser  Ala Thr Asp 
    2630                 2635                 2640             


Cys Ser  Ser Tyr Phe Arg Leu  Gly Val Lys Gly Val  Leu Phe Gln 
    2645                 2650                 2655             


Pro Cys  Glu Arg Thr Ser Leu  Cys Tyr Ala Pro Ser  Trp Val Cys 
    2660                 2665                 2670             


Asp Gly  Ala Asn Asp Cys Gly  Asp Tyr Ser Asp Glu  Arg Asp Cys 
    2675                 2680                 2685             


Pro Gly  Val Lys Arg Pro Arg  Cys Pro Leu Asn Tyr  Phe Ala Cys 
    2690                 2695                 2700             


Pro Ser  Gly Arg Cys Ile Pro  Met Ser Trp Thr Cys  Asp Lys Glu 
    2705                 2710                 2715             


Asp Asp  Cys Glu His Gly Glu  Asp Glu Thr His Cys  Asn Lys Phe 
    2720                 2725                 2730             


Cys Ser  Glu Ala Gln Phe Glu  Cys Gln Asn His Arg  Cys Ile Ser 
    2735                 2740                 2745             


Lys Gln  Trp Leu Cys Asp Gly  Ser Asp Asp Cys Gly  Asp Gly Ser 
    2750                 2755                 2760             


Asp Glu  Ala Ala His Cys Glu  Gly Lys Thr Cys Gly  Pro Ser Ser 
    2765                 2770                 2775             


Phe Ser  Cys Pro Gly Thr His  Val Cys Val Pro Glu  Arg Trp Leu 
    2780                 2785                 2790             


Cys Asp  Gly Asp Lys Asp Cys  Ala Asp Gly Ala Asp  Glu Ser Ile 
    2795                 2800                 2805             


Ala Ala  Gly Cys Leu Tyr Asn  Ser Thr Cys Asp Asp  Arg Glu Phe 
    2810                 2815                 2820             


Met Cys  Gln Asn Arg Gln Cys  Ile Pro Lys His Phe  Val Cys Asp 
    2825                 2830                 2835             


His Asp  Arg Asp Cys Ala Asp  Gly Ser Asp Glu Ser  Pro Glu Cys 
    2840                 2845                 2850             


Glu Tyr  Pro Thr Cys Gly Pro  Ser Glu Phe Arg Cys  Ala Asn Gly 
    2855                 2860                 2865             


Arg Cys  Leu Ser Ser Arg Gln  Trp Glu Cys Asp Gly  Glu Asn Asp 
    2870                 2875                 2880             


Cys His  Asp Gln Ser Asp Glu  Ala Pro Lys Asn Pro  His Cys Thr 
    2885                 2890                 2895             


Ser Gln  Glu His Lys Cys Asn  Ala Ser Ser Gln Phe  Leu Cys Ser 
    2900                 2905                 2910             


Ser Gly  Arg Cys Val Ala Glu  Ala Leu Leu Cys Asn  Gly Gln Asp 
    2915                 2920                 2925             


Asp Cys  Gly Asp Ser Ser Asp  Glu Arg Gly Cys His  Ile Asn Glu 
    2930                 2935                 2940             


Cys Leu  Ser Arg Lys Leu Ser  Gly Cys Ser Gln Asp  Cys Glu Asp 
    2945                 2950                 2955             


Leu Lys  Ile Gly Phe Lys Cys  Arg Cys Arg Pro Gly  Phe Arg Leu 
    2960                 2965                 2970             


Lys Asp  Asp Gly Arg Thr Cys  Ala Asp Val Asp Glu  Cys Ser Thr 
    2975                 2980                 2985             


Thr Phe  Pro Cys Ser Gln Arg  Cys Ile Asn Thr His  Gly Ser Tyr 
    2990                 2995                 3000             


Lys Cys  Leu Cys Val Glu Gly  Tyr Ala Pro Arg Gly  Gly Asp Pro 
    3005                 3010                 3015             


His Ser  Cys Lys Ala Val Thr  Asp Glu Glu Pro Phe  Leu Ile Phe 
    3020                 3025                 3030             


Ala Asn  Arg Tyr Tyr Leu Arg  Lys Leu Asn Leu Asp  Gly Ser Asn 
    3035                 3040                 3045             


Tyr Thr  Leu Leu Lys Gln Gly  Leu Asn Asn Ala Val  Ala Leu Asp 
    3050                 3055                 3060             


Phe Asp  Tyr Arg Glu Gln Met  Ile Tyr Trp Thr Asp  Val Thr Thr 
    3065                 3070                 3075             


Gln Gly  Ser Met Ile Arg Arg  Met His Leu Asn Gly  Ser Asn Val 
    3080                 3085                 3090             


Gln Val  Leu His Arg Thr Gly  Leu Ser Asn Pro Asp  Gly Leu Ala 
    3095                 3100                 3105             


Val Asp  Trp Val Gly Gly Asn  Leu Tyr Trp Cys Asp  Lys Gly Arg 
    3110                 3115                 3120             


Asp Thr  Ile Glu Val Ser Lys  Leu Asn Gly Ala Tyr  Arg Thr Val 
    3125                 3130                 3135             


Leu Val  Ser Ser Gly Leu Arg  Glu Pro Arg Ala Leu  Val Val Asp 
    3140                 3145                 3150             


Val Gln  Asn Gly Tyr Leu Tyr  Trp Thr Asp Trp Gly  Asp His Ser 
    3155                 3160                 3165             


Leu Ile  Gly Arg Ile Gly Met  Asp Gly Ser Ser Arg  Ser Val Ile 
    3170                 3175                 3180             


Val Asp  Thr Lys Ile Thr Trp  Pro Asn Gly Leu Thr  Leu Asp Tyr 
    3185                 3190                 3195             


Val Thr  Glu Arg Ile Tyr Trp  Ala Asp Ala Arg Glu  Asp Tyr Ile 
    3200                 3205                 3210             


Glu Phe  Ala Ser Leu Asp Gly  Ser Asn Arg His Val  Val Leu Ser 
    3215                 3220                 3225             


Gln Asp  Ile Pro His Ile Phe  Ala Leu Thr Leu Phe  Glu Asp Tyr 
    3230                 3235                 3240             


Val Tyr  Trp Thr Asp Trp Glu  Thr Lys Ser Ile Asn  Arg Ala His 
    3245                 3250                 3255             


Lys Thr  Thr Gly Thr Asn Lys  Thr Leu Leu Ile Ser  Thr Leu His 
    3260                 3265                 3270             


Arg Pro  Met Asp Leu His Val  Phe His Ala Leu Arg  Gln Pro Asp 
    3275                 3280                 3285             


Val Pro  Asn His Pro Cys Lys  Val Asn Asn Gly Gly  Cys Ser Asn 
    3290                 3295                 3300             


Leu Cys  Leu Leu Ser Pro Gly  Gly Gly His Lys Cys  Ala Cys Pro 
    3305                 3310                 3315             


Thr Asn  Phe Tyr Leu Gly Ser  Asp Gly Arg Thr Cys  Val Ser Asn 
    3320                 3325                 3330             


Cys Thr  Ala Ser Gln Phe Val  Cys Lys Asn Asp Lys  Cys Ile Pro 
    3335                 3340                 3345             


Phe Trp  Trp Lys Cys Asp Thr  Glu Asp Asp Cys Gly  Asp His Ser 
    3350                 3355                 3360             


Asp Glu  Pro Pro Asp Cys Pro  Glu Phe Lys Cys Arg  Pro Gly Gln 
    3365                 3370                 3375             


Phe Gln  Cys Ser Thr Gly Ile  Cys Thr Asn Pro Ala  Phe Ile Cys 
    3380                 3385                 3390             


Asp Gly  Asp Asn Asp Cys Gln  Asp Asn Ser Asp Glu  Ala Asn Cys 
    3395                 3400                 3405             


Asp Ile  His Val Cys Leu Pro  Ser Gln Phe Lys Cys  Thr Asn Thr 
    3410                 3415                 3420             


Asn Arg  Cys Ile Pro Gly Ile  Phe Arg Cys Asn Gly  Gln Asp Asn 
    3425                 3430                 3435             


Cys Gly  Asp Gly Glu Asp Glu  Arg Asp Cys Pro Glu  Val Thr Cys 
    3440                 3445                 3450             


Ala Pro  Asn Gln Phe Gln Cys  Ser Ile Thr Lys Arg  Cys Ile Pro 
    3455                 3460                 3465             


Arg Val  Trp Val Cys Asp Arg  Asp Asn Asp Cys Val  Asp Gly Ser 
    3470                 3475                 3480             


Asp Glu  Pro Ala Asn Cys Thr  Gln Met Thr Cys Gly  Val Asp Glu 
    3485                 3490                 3495             


Phe Arg  Cys Lys Asp Ser Gly  Arg Cys Ile Pro Ala  Arg Trp Lys 
    3500                 3505                 3510             


Cys Asp  Gly Glu Asp Asp Cys  Gly Asp Gly Ser Asp  Glu Pro Lys 
    3515                 3520                 3525             


Glu Glu  Cys Asp Glu Arg Thr  Cys Glu Pro Tyr Gln  Phe Arg Cys 
    3530                 3535                 3540             


Lys Asn  Asn Arg Cys Val Pro  Gly Arg Trp Gln Cys  Asp Tyr Asp 
    3545                 3550                 3555             


Asn Asp  Cys Gly Asp Asn Ser  Asp Glu Glu Ser Cys  Thr Pro Arg 
    3560                 3565                 3570             


Pro Cys  Ser Glu Ser Glu Phe  Ser Cys Ala Asn Gly  Arg Cys Ile 
    3575                 3580                 3585             


Ala Gly  Arg Trp Lys Cys Asp  Gly Asp His Asp Cys  Ala Asp Gly 
    3590                 3595                 3600             


Ser Asp  Glu Lys Asp Cys Thr  Pro Arg Cys Asp Met  Asp Gln Phe 
    3605                 3610                 3615             


Gln Cys  Lys Ser Gly His Cys  Ile Pro Leu Arg Trp  Arg Cys Asp 
    3620                 3625                 3630             


Ala Asp  Ala Asp Cys Met Asp  Gly Ser Asp Glu Glu  Ala Cys Gly 
    3635                 3640                 3645             


Thr Gly  Val Arg Thr Cys Pro  Leu Asp Glu Phe Gln  Cys Asn Asn 
    3650                 3655                 3660             


Thr Leu  Cys Lys Pro Leu Ala  Trp Lys Cys Asp Gly  Glu Asp Asp 
    3665                 3670                 3675             


Cys Gly  Asp Asn Ser Asp Glu  Asn Pro Glu Glu Cys  Ala Arg Phe 
    3680                 3685                 3690             


Val Cys  Pro Pro Asn Arg Pro  Phe Arg Cys Lys Asn  Asp Arg Val 
    3695                 3700                 3705             


Cys Leu  Trp Ile Gly Arg Gln  Cys Asp Gly Thr Asp  Asn Cys Gly 
    3710                 3715                 3720             


Asp Gly  Thr Asp Glu Glu Asp  Cys Glu Pro Pro Thr  Ala His Thr 
    3725                 3730                 3735             


Thr His  Cys Lys Asp Lys Lys  Glu Phe Leu Cys Arg  Asn Gln Arg 
    3740                 3745                 3750             


Cys Leu  Ser Ser Ser Leu Arg  Cys Asn Met Phe Asp  Asp Cys Gly 
    3755                 3760                 3765             


Asp Gly  Ser Asp Glu Glu Asp  Cys Ser Ile Asp Pro  Lys Leu Thr 
    3770                 3775                 3780             


Ser Cys  Ala Thr Asn Ala Ser  Ile Cys Gly Asp Glu  Ala Arg Cys 
    3785                 3790                 3795             


Val Arg  Thr Glu Lys Ala Ala  Tyr Cys Ala Cys Arg  Ser Gly Phe 
    3800                 3805                 3810             


His Thr  Val Pro Gly Gln Pro  Gly Cys Gln Asp Ile  Asn Glu Cys 
    3815                 3820                 3825             


Leu Arg  Phe Gly Thr Cys Ser  Gln Leu Cys Asn Asn  Thr Lys Gly 
    3830                 3835                 3840             


Gly His  Leu Cys Ser Cys Ala  Arg Asn Phe Met Lys  Thr His Asn 
    3845                 3850                 3855             


Thr Cys  Lys Ala Glu Gly Ser  Glu Tyr Gln Val Leu  Tyr Ile Ala 
    3860                 3865                 3870             


Asp Asp  Asn Glu Ile Arg Ser  Leu Phe Pro Gly His  Pro His Ser 
    3875                 3880                 3885             


Ala Tyr  Glu Gln Ala Phe Gln  Gly Asp Glu Ser Val  Arg Ile Asp 
    3890                 3895                 3900             


Ala Met  Asp Val His Val Lys  Ala Gly Arg Val Tyr  Trp Thr Asn 
    3905                 3910                 3915             


Trp His  Thr Gly Thr Ile Ser  Tyr Arg Ser Leu Pro  Pro Ala Ala 
    3920                 3925                 3930             


Pro Pro  Thr Thr Ser Asn Arg  His Arg Arg Gln Ile  Asp Arg Gly 
    3935                 3940                 3945             


Val Thr  His Leu Asn Ile Ser  Gly Leu Lys Met Pro  Arg Gly Ile 
    3950                 3955                 3960             


Ala Ile  Asp Trp Val Ala Gly  Asn Val Tyr Trp Thr  Asp Ser Gly 
    3965                 3970                 3975             


Arg Asp  Val Ile Glu Val Ala  Gln Met Lys Gly Glu  Asn Arg Lys 
    3980                 3985                 3990             


Thr Leu  Ile Ser Gly Met Ile  Asp Glu Pro His Ala  Ile Val Val 
    3995                 4000                 4005             


Asp Pro  Leu Arg Gly Thr Met  Tyr Trp Ser Asp Trp  Gly Asn His 
    4010                 4015                 4020             


Pro Lys  Ile Glu Thr Ala Ala  Met Asp Gly Thr Leu  Arg Glu Thr 
    4025                 4030                 4035             


Leu Val  Gln Asp Asn Ile Gln  Trp Pro Thr Gly Leu  Ala Val Asp 
    4040                 4045                 4050             


Tyr His  Asn Glu Arg Leu Tyr  Trp Ala Asp Ala Lys  Leu Ser Val 
    4055                 4060                 4065             


Ile Gly  Ser Ile Arg Leu Asn  Gly Thr Asp Pro Ile  Val Ala Ala 
    4070                 4075                 4080             


Asp Ser  Lys Arg Gly Leu Ser  His Pro Phe Ser Ile  Asp Val Phe 
    4085                 4090                 4095             


Glu Asp  Tyr Ile Tyr Gly Val  Thr Tyr Ile Asn Asn  Arg Val Phe 
    4100                 4105                 4110             


Lys Ile  His Lys Phe Gly His  Ser Pro Leu Val Asn  Leu Thr Gly 
    4115                 4120                 4125             


Gly Leu  Ser His Ala Ser Asp  Val Val Leu Tyr His  Gln His Lys 
    4130                 4135                 4140             


Gln Pro  Glu Val Thr Asn Pro  Cys Asp Arg Lys Lys  Cys Glu Trp 
    4145                 4150                 4155             


Leu Cys  Leu Leu Ser Pro Ser  Gly Pro Val Cys Thr  Cys Pro Asn 
    4160                 4165                 4170             


Gly Lys  Arg Leu Asp Asn Gly  Thr Cys Val Pro Val  Pro Ser Pro 
    4175                 4180                 4185             


Thr Pro  Pro Pro Asp Ala Pro  Arg Pro Gly Thr Cys  Asn Leu Gln 
    4190                 4195                 4200             


Cys Phe  Asn Gly Gly Ser Cys  Phe Leu Asn Ala Arg  Arg Gln Pro 
    4205                 4210                 4215             


Lys Cys  Arg Cys Gln Pro Arg  Tyr Thr Gly Asp Lys  Cys Glu Leu 
    4220                 4225                 4230             


Asp Gln  Cys Trp Glu His Cys  Arg Asn Gly Gly Thr  Cys Ala Ala 
    4235                 4240                 4245             


Ser Pro  Ser Gly Met Pro Thr  Cys Arg Cys Pro Thr  Gly Phe Thr 
    4250                 4255                 4260             


Gly Pro  Lys Cys Thr Gln Gln  Val Cys Ala Gly Tyr  Cys Ala Asn 
    4265                 4270                 4275             


Asn Ser  Thr Cys Thr Val Asn  Gln Gly Asn Gln Pro  Gln Cys Arg 
    4280                 4285                 4290             


Cys Leu  Pro Gly Phe Leu Gly  Asp Arg Cys Gln Tyr  Arg Gln Cys 
    4295                 4300                 4305             


Ser Gly  Tyr Cys Glu Asn Phe  Gly Thr Cys Gln Met  Ala Ala Asp 
    4310                 4315                 4320             


Gly Ser  Arg Gln Cys Arg Cys  Thr Ala Tyr Phe Glu  Gly Ser Arg 
    4325                 4330                 4335             


Cys Glu  Val Asn Lys Cys Ser  Arg Cys Leu Glu Gly  Ala Cys Val 
    4340                 4345                 4350             


Val Asn  Lys Gln Ser Gly Asp  Val Thr Cys Asn Cys  Thr Asp Gly 
    4355                 4360                 4365             


Arg Val  Ala Pro Ser Cys Leu  Thr Cys Val Gly His  Cys Ser Asn 
    4370                 4375                 4380             


Gly Gly  Ser Cys Thr Met Asn  Ser Lys Met Met Pro  Glu Cys Gln 
    4385                 4390                 4395             


Cys Pro  Pro His Met Thr Gly  Pro Arg Cys Glu Glu  His Val Phe 
    4400                 4405                 4410             


Ser Gln  Gln Gln Pro Gly His  Ile Ala Ser Ile Leu  Ile Pro Leu 
    4415                 4420                 4425             


Leu Leu  Leu Leu Leu Leu Val  Leu Val Ala Gly Val  Val Phe Trp 
    4430                 4435                 4440             


Tyr Lys  Arg Arg Val Gln Gly  Ala Lys Gly Phe Gln  His Gln Arg 
    4445                 4450                 4455             


Met Thr  Asn Gly Ala Met Asn  Val Glu Ile Gly Asn  Pro Thr Tyr 
    4460                 4465                 4470             


Lys Met  Tyr Glu Gly Gly Glu  Pro Asp Asp Val Gly  Gly Leu Leu 
    4475                 4480                 4485             


Asp Ala  Asp Phe Ala Leu Asp  Pro Asp Lys Pro Thr  Asn Phe Thr 
    4490                 4495                 4500             


Asn Pro  Val Tyr Ala Thr Leu  Tyr Met Gly Gly His  Gly Ser Arg 
    4505                 4510                 4515             


His Ser  Leu Ala Ser Thr Asp  Glu Lys Arg Glu Leu  Leu Gly Arg 
    4520                 4525                 4530             


Gly Pro  Glu Asp Glu Ile Gly  Asp Pro Leu Ala 
    4535                 4540                 


<210>  8005
<211>  292
<212>  PRT
<213>  Homo Sapiens

<400>  8005

Met Leu Thr Pro Pro Leu Leu Leu Leu Leu Pro Leu Leu Ser Ala Leu 
1               5                   10                  15      


Val Ala Ala Ala Ile Asp Ala Pro Lys Thr Cys Ser Pro Lys Gln Phe 
            20                  25                  30          


Ala Cys Arg Asp Gln Ile Thr Cys Ile Ser Lys Gly Trp Arg Cys Asp 
        35                  40                  45              


Gly Glu Arg Asp Cys Pro Asp Gly Ser Asp Glu Ala Pro Glu Ile Cys 
    50                  55                  60                  


Pro Gln Ser Lys Ala Gln Arg Cys Gln Pro Asn Glu His Asn Cys Leu 
65                  70                  75                  80  


Gly Thr Glu Leu Cys Val Pro Met Ser Arg Leu Cys Asn Gly Val Gln 
                85                  90                  95      


Asp Cys Met Asp Gly Ser Asp Glu Gly Pro His Cys Arg Glu Leu Gln 
            100                 105                 110         


Gly Asn Cys Ser Arg Leu Gly Cys Gln His His Cys Val Pro Thr Leu 
        115                 120                 125             


Asp Gly Pro Thr Cys Tyr Cys Asn Ser Ser Phe Gln Leu Gln Ala Asp 
    130                 135                 140                 


Gly Lys Thr Cys Lys Asp Phe Asp Glu Cys Ser Val Tyr Gly Thr Cys 
145                 150                 155                 160 


Ser Gln Leu Cys Thr Asn Thr Asp Gly Ser Phe Ile Cys Gly Cys Val 
                165                 170                 175     


Glu Gly Tyr Leu Leu Gln Pro Asp Asn Arg Ser Cys Lys Ala Lys Asn 
            180                 185                 190         


Glu Pro Val Asp Arg Pro Pro Val Leu Leu Ile Ala Asn Ser Gln Asn 
        195                 200                 205             


Ile Leu Ala Thr Tyr Leu Ser Gly Ala Gln Val Ser Thr Ile Thr Pro 
    210                 215                 220                 


Thr Ser Thr Arg Gln Thr Thr Ala Met Asp Phe Ser Tyr Ala Asn Glu 
225                 230                 235                 240 


Thr Val Cys Trp Val His Val Gly Asp Ser Ala Ala Gln Thr Gln Leu 
                245                 250                 255     


Lys Cys Ala Arg Met Pro Gly Leu Lys Gly Phe Val Asp Glu His Thr 
            260                 265                 270         


Ile Asn Ile Ser Leu Ser Leu His Leu Cys Val Phe Ser Lys Ser Gln 
        275                 280                 285             


Gln Glu Met Gly 
    290         


<210>  8006
<211>  296
<212>  PRT
<213>  Homo Sapiens

<400>  8006

Met Leu Thr Pro Pro Leu Leu Leu Leu Leu Pro Leu Leu Ser Ala Leu 
1               5                   10                  15      


Val Ala Ala Ala Ile Asp Ala Pro Lys Thr Cys Ser Pro Lys Gln Phe 
            20                  25                  30          


Ala Cys Arg Asp Gln Ile Thr Cys Ile Ser Lys Gly Trp Arg Cys Asp 
        35                  40                  45              


Gly Glu Arg Asp Cys Pro Asp Gly Ser Asp Glu Ala Pro Glu Ile Cys 
    50                  55                  60                  


Pro Gln Ser Lys Ala Gln Arg Cys Gln Pro Asn Glu His Asn Cys Leu 
65                  70                  75                  80  


Gly Thr Glu Leu Cys Val Pro Met Ser Arg Leu Cys Asn Gly Val Gln 
                85                  90                  95      


Asp Cys Met Asp Gly Ser Asp Glu Gly Pro His Cys Arg Glu Leu Gln 
            100                 105                 110         


Gly Asn Cys Ser Arg Leu Gly Cys Gln His His Cys Val Pro Thr Leu 
        115                 120                 125             


Asp Gly Pro Thr Cys Tyr Cys Asn Ser Ser Phe Gln Leu Gln Ala Asp 
    130                 135                 140                 


Gly Lys Thr Cys Lys Asp Phe Asp Glu Cys Ser Val Tyr Gly Thr Cys 
145                 150                 155                 160 


Ser Gln Leu Cys Thr Asn Thr Asp Gly Ser Phe Ile Cys Gly Cys Val 
                165                 170                 175     


Glu Gly Tyr Leu Leu Gln Pro Asp Asn Arg Ser Cys Lys Ala Lys Asn 
            180                 185                 190         


Glu Pro Val Asp Arg Pro Pro Val Leu Leu Ile Ala Asn Ser Gln Asn 
        195                 200                 205             


Ile Leu Ala Thr Tyr Leu Ser Gly Ala Gln Val Ser Thr Ile Thr Pro 
    210                 215                 220                 


Thr Ser Thr Arg Gln Thr Thr Ala Met Asp Phe Ser Tyr Ala Asn Glu 
225                 230                 235                 240 


Thr Val Cys Trp Val His Val Gly Asp Ser Ala Ala Gln Thr Gln Leu 
                245                 250                 255     


Lys Cys Ala Arg Met Pro Gly Leu Lys Gly Phe Val Asp Glu His Thr 
            260                 265                 270         


Ile Asn Ile Ser Leu Ser Leu His Arg Arg Ser Arg Lys Arg Ala Gln 
        275                 280                 285             


Glu Asn Glu Val Thr Gln His Gly 
    290                 295     


<210>  8007
<211>  439
<212>  PRT
<213>  Homo Sapiens

<400>  8007

Met Leu Thr Pro Pro Leu Leu Leu Leu Leu Pro Leu Leu Ser Ala Leu 
1               5                   10                  15      


Val Ala Ala Ala Ile Asp Ala Pro Lys Thr Cys Ser Pro Lys Gln Phe 
            20                  25                  30          


Ala Cys Arg Asp Gln Ile Thr Cys Ile Ser Lys Gly Trp Arg Cys Asp 
        35                  40                  45              


Gly Glu Arg Asp Cys Pro Asp Gly Ser Asp Glu Ala Pro Glu Ile Cys 
    50                  55                  60                  


Pro Gln Ser Lys Ala Gln Arg Cys Gln Pro Asn Glu His Asn Cys Leu 
65                  70                  75                  80  


Gly Thr Glu Leu Cys Val Pro Met Ser Arg Leu Cys Asn Gly Val Gln 
                85                  90                  95      


Asp Cys Met Asp Gly Ser Asp Glu Gly Pro His Cys Arg Glu Leu Gln 
            100                 105                 110         


Gly Asn Cys Ser Arg Leu Gly Cys Gln His His Cys Val Pro Thr Leu 
        115                 120                 125             


Asp Gly Pro Thr Cys Tyr Cys Asn Ser Ser Phe Gln Leu Gln Ala Asp 
    130                 135                 140                 


Gly Lys Thr Cys Lys Asp Phe Asp Glu Cys Ser Val Tyr Gly Thr Cys 
145                 150                 155                 160 


Ser Gln Leu Cys Thr Asn Thr Asp Gly Ser Phe Ile Cys Gly Cys Val 
                165                 170                 175     


Glu Gly Tyr Leu Leu Gln Pro Asp Asn Arg Ser Cys Lys Ala Lys Asn 
            180                 185                 190         


Glu Pro Val Asp Arg Pro Pro Val Leu Leu Ile Ala Asn Ser Gln Asn 
        195                 200                 205             


Ile Leu Ala Thr Tyr Leu Ser Gly Ala Gln Val Ser Thr Ile Thr Pro 
    210                 215                 220                 


Thr Ser Thr Arg Gln Thr Thr Ala Met Asp Phe Ser Tyr Ala Asn Glu 
225                 230                 235                 240 


Thr Val Cys Trp Val His Val Gly Asp Ser Ala Ala Gln Thr Gln Leu 
                245                 250                 255     


Lys Cys Ala Arg Met Pro Gly Leu Lys Gly Phe Val Asp Glu His Thr 
            260                 265                 270         


Ile Asn Ile Ser Leu Ser Leu His His Val Glu Gln Met Ala Ile Asp 
        275                 280                 285             


Trp Leu Thr Gly Asn Phe Tyr Phe Val Asp Asp Ile Asp Asp Arg Ile 
    290                 295                 300                 


Phe Val Cys Asn Arg Asn Gly Asp Thr Cys Val Thr Leu Leu Asp Leu 
305                 310                 315                 320 


Glu Leu Tyr Asn Pro Lys Gly Ile Ala Leu Asp Pro Ala Met Gly Lys 
                325                 330                 335     


Val Phe Phe Thr Asp Tyr Gly Gln Ile Pro Lys Val Glu Arg Cys Asp 
            340                 345                 350         


Met Asp Gly Gln Asn Arg Thr Lys Leu Val Asp Ser Lys Ile Val Phe 
        355                 360                 365             


Pro His Gly Ile Thr Leu Asp Leu Val Ser Arg Leu Val Tyr Trp Ala 
    370                 375                 380                 


Asp Ala Tyr Leu Asp Tyr Ile Glu Val Val Asp Tyr Glu Gly Lys Gly 
385                 390                 395                 400 


Arg Gln Thr Ile Ile Gln Gly Ile Leu Val Arg Glu Leu Leu Ser Glu 
                405                 410                 415     


Val Leu Trp Gly Asn His Asp Pro Gly Pro Ser Gly Glu Gly Gly Ser 
            420                 425                 430         


Leu Cys Arg Gly Thr Val Leu 
        435                 


<210>  8008
<211>  183
<212>  PRT
<213>  Homo Sapiens

<400>  8008

Asn Gly Gln Asp Asn Cys Gly Asp Gly Glu Asp Glu Arg Asp Cys Pro 
1               5                   10                  15      


Glu Val Thr Cys Ala Pro Asn Gln Phe Gln Cys Ser Ile Thr Lys Arg 
            20                  25                  30          


Cys Ile Pro Arg Val Trp Val Cys Asp Arg Asp Asn Asp Cys Val Asp 
        35                  40                  45              


Gly Ser Asp Glu Pro Ala Asn Cys Thr Gln Met Thr Cys Gly Val Asp 
    50                  55                  60                  


Glu Phe Arg Cys Lys Asp Ser Gly Arg Cys Ile Pro Ala Arg Trp Lys 
65                  70                  75                  80  


Cys Asp Gly Glu Asp Asp Cys Gly Asp Gly Ser Asp Glu Pro Lys Glu 
                85                  90                  95      


Glu Cys Gly Glu Pro Arg Pro His Ser Arg Arg Lys Thr Val Tyr Leu 
            100                 105                 110         


Asp Glu Arg Thr Cys Glu Pro Tyr Gln Phe Arg Cys Lys Asn Asn Arg 
        115                 120                 125             


Cys Val Pro Gly Arg Trp Gln Cys Asp Tyr Asp Asn Asp Cys Gly Asp 
    130                 135                 140                 


Asn Ser Asp Glu Glu Ser Cys Thr Pro Arg Pro Cys Ser Glu Ser Glu 
145                 150                 155                 160 


Phe Ser Cys Ala Asn Gly Arg Cys Ile Ala Gly Arg Trp Lys Cys Asp 
                165                 170                 175     


Gly Asp His Asp Cys Ala Asp 
            180             


<210>  8009
<211>  139
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8009

Xaa Arg Pro Gly Ala Phe Glu Arg Glu Thr Val Ile Thr Met Ser Gly 
1               5                   10                  15      


Asp Asp His Pro Arg Ala Phe Val Leu Asp Glu Cys Gln Asn Leu Met 
            20                  25                  30          


Phe Trp Thr Asn Trp Asn Glu Gln His Pro Ser Ile Met Arg Ala Ala 
        35                  40                  45              


Leu Ser Gly Ala Asn Val Leu Thr Leu Ile Glu Lys Asp Ile Arg Thr 
    50                  55                  60                  


Pro Asn Gly Leu Ala Ile Asp His Arg Ala Glu Lys Leu Tyr Phe Ser 
65                  70                  75                  80  


Asp Ala Thr Leu Asp Lys Ile Glu Arg Cys Glu Tyr Asp Gly Ser His 
                85                  90                  95      


Arg Tyr Val Asn Ser Leu His Ala Glu Ser Thr Thr Val Ala Ala Arg 
            100                 105                 110         


Thr Cys Val Cys Ser Leu Thr Arg Ala Met Ser Thr Ala His Ala Glu 
        115                 120                 125             


Gly Ala Glu Ser Ser Arg Met Thr Ser Pro Ala 
    130                 135                 


<210>  8010
<211>  500
<212>  PRT
<213>  Homo Sapiens

<400>  8010

Met Ala Ser Val Ala Gln Glu Ser Ala Gly Ser Gln Arg Arg Leu Pro 
1               5                   10                  15      


Pro Arg His Gly Ala Leu Arg Gly Leu Leu Leu Leu Cys Leu Trp Leu 
            20                  25                  30          


Pro Ser Gly Arg Ala Ala Leu Pro Pro Ala Ala Pro Leu Ser Glu Leu 
        35                  40                  45              


His Ala Gln Leu Ser Gly Val Glu Gln Leu Leu Glu Glu Phe Arg Arg 
    50                  55                  60                  


Gln Leu Gln Gln Glu Arg Pro Gln Glu Glu Leu Glu Leu Glu Leu Arg 
65                  70                  75                  80  


Ala Gly Gly Gly Pro Gln Glu Asp Cys Pro Gly Pro Gly Ser Gly Gly 
                85                  90                  95      


Tyr Ser Ala Met Pro Asp Ala Ile Ile Arg Thr Lys Asp Ser Leu Ala 
            100                 105                 110         


Ala Gly Ala Ser Phe Leu Arg Ala Pro Ala Ala Val Arg Gly Trp Arg 
        115                 120                 125             


Gln Cys Val Ala Ala Cys Cys Ser Glu Pro Arg Cys Ser Val Ala Val 
    130                 135                 140                 


Val Glu Leu Pro Arg Arg Pro Ala Pro Pro Ala Ala Val Leu Gly Cys 
145                 150                 155                 160 


Tyr Leu Phe Asn Cys Thr Ala Arg Gly Arg Asn Val Cys Lys Phe Ala 
                165                 170                 175     


Leu His Ser Gly Tyr Ser Ser Tyr Ser Leu Ser Arg Ala Pro Asp Gly 
            180                 185                 190         


Ala Ala Leu Ala Thr Ala Arg Ala Ser Pro Arg Gln Glu Lys Asp Ala 
        195                 200                 205             


Pro Pro Leu Ser Lys Ala Gly Gln Asp Val Val Leu His Leu Pro Thr 
    210                 215                 220                 


Asp Gly Val Val Leu Asp Gly Arg Glu Ser Thr Asp Asp His Ala Ile 
225                 230                 235                 240 


Val Gln Tyr Glu Trp Ala Leu Leu Gln Gly Asp Pro Ser Val Asp Met 
                245                 250                 255     


Lys Val Pro Gln Ser Gly Thr Leu Lys Leu Ser His Leu Gln Glu Gly 
            260                 265                 270         


Thr Tyr Thr Phe Gln Leu Thr Val Thr Asp Thr Ala Gly Gln Arg Ser 
        275                 280                 285             


Ser Asp Asn Val Ser Val Thr Val Leu Arg Ala Ala Tyr Ser Thr Gly 
    290                 295                 300                 


Gly Cys Leu His Thr Cys Ser Arg Tyr His Phe Phe Cys Asp Asp Gly 
305                 310                 315                 320 


Cys Cys Ile Asp Ile Thr Leu Ala Cys Asp Gly Val Gln Gln Cys Pro 
                325                 330                 335     


Asp Gly Ser Asp Glu Asp Phe Cys Gln Asn Leu Gly Leu Asp Arg Lys 
            340                 345                 350         


Met Val Thr His Thr Ala Ala Ser Pro Ala Leu Pro Arg Thr Thr Gly 
        355                 360                 365             


Pro Ser Glu Asp Ala Gly Gly Asp Ser Leu Val Glu Lys Ser Gln Lys 
    370                 375                 380                 


Ala Thr Ala Pro Asn Lys Pro Pro Ala Leu Ser Asn Thr Glu Lys Arg 
385                 390                 395                 400 


Asn His Ser Ala Phe Trp Gly Pro Glu Ser Gln Ile Ile Pro Val Met 
                405                 410                 415     


Pro Asp Ser Ser Ser Ser Gly Lys Asn Arg Lys Glu Glu Ser Tyr Ile 
            420                 425                 430         


Phe Glu Ser Lys Gly Asp Gly Gly Gly Gly Glu His Pro Ala Pro Glu 
        435                 440                 445             


Thr Gly Ala Val Leu Pro Leu Ala Leu Gly Leu Ala Ile Thr Ala Leu 
    450                 455                 460                 


Leu Leu Leu Met Val Ala Cys Arg Leu Arg Leu Val Lys Gln Lys Leu 
465                 470                 475                 480 


Lys Lys Ala Arg Pro Ile Thr Ser Glu Glu Ser Asp Tyr Leu Ile Asn 
                485                 490                 495     


Gly Met Tyr Leu 
            500 


<210>  8011
<211>  325
<212>  PRT
<213>  Homo Sapiens

<400>  8011

Met Ala Ser Val Ala Gln Glu Ser Ala Gly Ser Gln Arg Arg Leu Pro 
1               5                   10                  15      


Pro Arg His Gly Ala Leu Arg Gly Leu Leu Leu Leu Cys Leu Trp Leu 
            20                  25                  30          


Pro Ser Gly Arg Ala Ala Leu Pro Pro Ala Ala Pro Leu Ser Glu Leu 
        35                  40                  45              


His Ala Gln Leu Ser Gly Val Glu Gln Leu Leu Glu Glu Phe Arg Arg 
    50                  55                  60                  


Gln Leu Gln Gln Glu Arg Pro Gln Glu Glu Leu Glu Leu Glu Leu Arg 
65                  70                  75                  80  


Ala Gly Gly Gly Pro Gln Glu Asp Cys Pro Gly Pro Gly Ser Gly Gly 
                85                  90                  95      


Tyr Ser Ala Met Pro Asp Ala Ile Ile Arg Thr Lys Asp Ser Leu Ala 
            100                 105                 110         


Ala Gly Ala Ser Phe Leu Arg Ala Pro Ala Ala Val Arg Gly Trp Arg 
        115                 120                 125             


Gln Cys Val Ala Ala Cys Cys Ser Glu Pro Arg Cys Ser Val Ala Val 
    130                 135                 140                 


Val Glu Leu Pro Arg Arg Pro Ala Pro Pro Ala Ala Val Leu Gly Cys 
145                 150                 155                 160 


Tyr Leu Phe Asn Cys Thr Ala Arg Gly Arg Asn Val Cys Lys Phe Ala 
                165                 170                 175     


Leu His Ser Gly Tyr Ser Ser Tyr Ser Leu Ser Arg Ala Pro Asp Gly 
            180                 185                 190         


Ala Ala Leu Ala Thr Ala Arg Ala Ser Pro Arg Gln Glu Lys Asp Ala 
        195                 200                 205             


Pro Pro Leu Ser Lys Ala Gly Gln Asp Val Val Leu His Leu Pro Thr 
    210                 215                 220                 


Asp Gly Val Val Leu Asp Gly Arg Glu Ser Thr Asp Asp His Ala Ile 
225                 230                 235                 240 


Val Gln Tyr Glu Trp Ala Leu Leu Gln Gly Asp Pro Ser Val Asp Met 
                245                 250                 255     


Lys Val Pro Gln Ser Gly Thr Leu Lys Leu Ser His Leu Gln Glu Gly 
            260                 265                 270         


Thr Tyr Thr Phe Gln Leu Thr Val Thr Asp Thr Ala Gly Gln Arg Ser 
        275                 280                 285             


Ser Asp Asn Val Ser Val Thr Val Leu Arg Ala Ala Tyr Ser Thr Gly 
    290                 295                 300                 


Asp Gly Trp Ser Ile Cys Cys Ile Cys Ser Lys Arg Glu Ala Lys Glu 
305                 310                 315                 320 


Phe Ser Glu Thr Ser 
                325 


<210>  8012
<211>  4599
<212>  PRT
<213>  Homo Sapiens

<400>  8012

Met Ser Glu Phe Leu Leu Ala Leu Leu Thr Leu Ser Gly Leu Leu Pro 
1               5                   10                  15      


Ile Ala Arg Val Leu Thr Val Gly Ala Asp Arg Asp Gln Gln Leu Cys 
            20                  25                  30          


Asp Pro Gly Glu Phe Leu Cys His Asp His Val Thr Cys Val Ser Gln 
        35                  40                  45              


Ser Trp Leu Cys Asp Gly Asp Pro Asp Cys Pro Asp Asp Ser Asp Glu 
    50                  55                  60                  


Ser Leu Asp Thr Cys Pro Glu Glu Val Glu Ile Lys Cys Pro Leu Asn 
65                  70                  75                  80  


His Ile Ala Cys Leu Gly Thr Asn Lys Cys Val His Leu Ser Gln Leu 
                85                  90                  95      


Cys Asn Gly Val Leu Asp Cys Pro Asp Gly Tyr Asp Glu Gly Val His 
            100                 105                 110         


Cys Gln Glu Leu Leu Ser Asn Cys Gln Gln Leu Asn Cys Gln Tyr Lys 
        115                 120                 125             


Cys Thr Met Val Arg Asn Ser Thr Arg Cys Tyr Cys Glu Asp Gly Phe 
    130                 135                 140                 


Glu Ile Thr Glu Asp Gly Arg Ser Cys Lys Asp Gln Asp Glu Cys Ala 
145                 150                 155                 160 


Val Tyr Gly Thr Cys Ser Gln Thr Cys Arg Asn Thr His Gly Ser Tyr 
                165                 170                 175     


Thr Cys Ser Cys Val Glu Gly Tyr Leu Met Gln Pro Asp Asn Arg Ser 
            180                 185                 190         


Cys Lys Ala Lys Ile Glu Pro Thr Asp Arg Pro Pro Ile Leu Leu Ile 
        195                 200                 205             


Ala Asn Phe Glu Thr Ile Glu Val Phe Tyr Leu Asn Gly Ser Lys Met 
    210                 215                 220                 


Ala Thr Leu Ser Ser Val Asn Gly Asn Glu Ile His Thr Leu Asp Phe 
225                 230                 235                 240 


Ile Tyr Asn Glu Asp Met Ile Cys Trp Ile Glu Ser Arg Glu Ser Ser 
                245                 250                 255     


Asn Gln Leu Lys Cys Ile Gln Ile Thr Lys Ala Gly Gly Leu Thr Asp 
            260                 265                 270         


Glu Trp Thr Ile Asn Ile Leu Gln Ser Phe His Asn Val Gln Gln Met 
        275                 280                 285             


Ala Ile Asp Trp Leu Thr Arg Asn Leu Tyr Phe Val Asp His Val Gly 
    290                 295                 300                 


Asp Arg Ile Phe Val Cys Asn Ser Asn Gly Ser Val Cys Val Thr Leu 
305                 310                 315                 320 


Ile Asp Leu Glu Leu His Asn Pro Lys Ala Ile Ala Val Asp Pro Ile 
                325                 330                 335     


Ala Gly Lys Leu Phe Phe Thr Asp Tyr Gly Asn Val Ala Lys Val Glu 
            340                 345                 350         


Arg Cys Asp Met Asp Gly Met Asn Arg Thr Arg Ile Ile Asp Ser Lys 
        355                 360                 365             


Thr Glu Gln Pro Ala Ala Leu Ala Leu Asp Leu Val Asn Lys Leu Val 
    370                 375                 380                 


Tyr Trp Val Asp Leu Tyr Leu Asp Tyr Val Gly Val Val Asp Tyr Gln 
385                 390                 395                 400 


Gly Lys Asn Arg His Thr Val Ile Gln Gly Arg Gln Val Arg His Leu 
                405                 410                 415     


Tyr Gly Ile Thr Val Phe Glu Asp Tyr Leu Tyr Ala Thr Asn Ser Asp 
            420                 425                 430         


Asn Tyr Asn Ile Val Arg Ile Asn Arg Phe Asn Gly Thr Asp Ile His 
        435                 440                 445             


Ser Leu Ile Lys Ile Glu Asn Ala Trp Gly Ile Arg Ile Tyr Gln Lys 
    450                 455                 460                 


Arg Thr Gln Pro Thr Val Arg Ser His Ala Cys Glu Val Asp Pro Tyr 
465                 470                 475                 480 


Gly Met Pro Gly Gly Cys Ser His Ile Cys Leu Leu Ser Ser Ser Tyr 
                485                 490                 495     


Lys Thr Arg Thr Cys Arg Cys Arg Thr Gly Phe Asn Leu Gly Ser Asp 
            500                 505                 510         


Gly Arg Ser Cys Lys Arg Pro Lys Asn Glu Leu Phe Leu Phe Tyr Gly 
        515                 520                 525             


Lys Gly Arg Pro Gly Ile Val Arg Gly Met Asp Leu Asn Thr Lys Ile 
    530                 535                 540                 


Ala Asp Glu Tyr Met Ile Pro Ile Glu Asn Leu Val Asn Pro Arg Ala 
545                 550                 555                 560 


Leu Asp Phe His Ala Glu Thr Asn Tyr Ile Tyr Phe Ala Asp Thr Thr 
                565                 570                 575     


Ser Phe Leu Ile Gly Arg Gln Lys Ile Asp Gly Thr Glu Arg Glu Thr 
            580                 585                 590         


Ile Leu Lys Asp Asp Leu Asp Asn Val Glu Gly Ile Ala Val Asp Trp 
        595                 600                 605             


Ile Gly Asn Asn Leu Tyr Trp Thr Asn Asp Gly His Arg Lys Thr Ile 
    610                 615                 620                 


Asn Val Ala Arg Leu Glu Lys Ala Ser Gln Ser Arg Lys Thr Leu Leu 
625                 630                 635                 640 


Glu Gly Glu Met Ser His Pro Arg Gly Ile Val Val Asp Pro Val Asn 
                645                 650                 655     


Gly Trp Met Tyr Trp Thr Asp Trp Glu Glu Asp Glu Ile Asp Asp Ser 
            660                 665                 670         


Val Gly Arg Ile Glu Lys Ala Trp Met Asp Gly Phe Asn Arg Gln Ile 
        675                 680                 685             


Phe Val Thr Ser Lys Met Leu Trp Pro Asn Gly Leu Thr Leu Asp Phe 
    690                 695                 700                 


His Thr Asn Thr Leu Tyr Trp Cys Asp Ala Tyr Tyr Asp His Ile Glu 
705                 710                 715                 720 


Lys Val Phe Leu Asn Gly Thr His Arg Lys Ile Val Tyr Ser Gly Arg 
                725                 730                 735     


Glu Leu Asn His Pro Phe Gly Leu Ser His His Gly Asn Tyr Val Phe 
            740                 745                 750         


Trp Thr Asp Tyr Met Asn Gly Ser Ile Phe Gln Leu Asp Leu Ile Thr 
        755                 760                 765             


Ser Glu Val Thr Leu Leu Arg His Glu Arg Pro Pro Leu Phe Gly Leu 
    770                 775                 780                 


Gln Ile Tyr Asp Pro Arg Lys Gln Gln Gly Asp Asn Met Cys Arg Val 
785                 790                 795                 800 


Asn Asn Gly Gly Cys Ser Thr Leu Cys Leu Ala Ile Pro Gly Gly Arg 
                805                 810                 815     


Val Cys Ala Cys Ala Asp Asn Gln Leu Leu Asp Glu Asn Gly Thr Thr 
            820                 825                 830         


Cys Thr Phe Asn Pro Gly Glu Ala Leu Pro His Ile Cys Lys Ala Gly 
        835                 840                 845             


Glu Phe Arg Cys Lys Asn Arg His Cys Ile Gln Ala Arg Trp Lys Cys 
    850                 855                 860                 


Asp Gly Asp Asp Asp Cys Leu Asp Gly Ser Asp Glu Asp Ser Val Asn 
865                 870                 875                 880 


Cys Phe Asn His Ser Cys Pro Asp Asp Gln Phe Lys Cys Gln Asn Asn 
                885                 890                 895     


Arg Cys Ile Pro Lys Arg Trp Leu Cys Asp Gly Ala Asn Asp Cys Gly 
            900                 905                 910         


Ser Asn Glu Asp Glu Ser Asn Gln Thr Cys Thr Ala Arg Thr Cys Gln 
        915                 920                 925             


Val Asp Gln Phe Ser Cys Gly Asn Gly Arg Cys Ile Pro Arg Ala Trp 
    930                 935                 940                 


Leu Cys Asp Arg Glu Asp Asp Cys Gly Asp Gln Thr Asp Glu Met Ala 
945                 950                 955                 960 


Ser Cys Glu Phe Pro Thr Cys Glu Pro Leu Thr Gln Phe Val Cys Lys 
                965                 970                 975     


Ser Gly Arg Cys Ile Ser Ser Lys Trp His Cys Asp Ser Asp Asp Asp 
            980                 985                 990         


Cys Gly Asp Gly Ser Asp Glu Val  Gly Cys Val His Ser  Cys Phe Asp 
        995                 1000                 1005             


Asn Gln  Phe Arg Cys Ser Ser  Gly Arg Cys Ile Pro  Gly His Trp 
    1010                 1015                 1020             


Ala Cys  Asp Gly Asp Asn Asp  Cys Gly Asp Phe Ser  Asp Glu Ala 
    1025                 1030                 1035             


Gln Ile  Asn Cys Thr Lys Glu  Glu Ile His Ser Pro  Ala Gly Cys 
    1040                 1045                 1050             


Asn Gly  Asn Glu Phe Gln Cys  His Pro Asp Gly Asn  Cys Val Pro 
    1055                 1060                 1065             


Asp Leu  Trp Arg Cys Asp Gly  Glu Lys Asp Cys Glu  Asp Gly Ser 
    1070                 1075                 1080             


Asp Glu  Lys Gly Cys Asn Gly  Thr Ile Arg Leu Cys  Asp His Lys 
    1085                 1090                 1095             


Thr Lys  Phe Ser Cys Trp Ser  Thr Gly Arg Cys Ile  Asn Lys Ala 
    1100                 1105                 1110             


Trp Val  Cys Asp Gly Asp Ile  Asp Cys Glu Asp Gln  Ser Asp Glu 
    1115                 1120                 1125             


Asp Asp  Cys Asp Ser Phe Leu  Cys Gly Pro Pro Lys  His Pro Cys 
    1130                 1135                 1140             


Ala Asn  Asp Thr Ser Val Cys  Leu Gln Pro Glu Lys  Leu Cys Asn 
    1145                 1150                 1155             


Gly Lys  Lys Asp Cys Pro Asp  Gly Ser Asp Glu Gly  Tyr Leu Cys 
    1160                 1165                 1170             


Asp Glu  Cys Ser Leu Asn Asn  Gly Gly Cys Ser Asn  His Cys Ser 
    1175                 1180                 1185             


Val Val  Pro Gly Arg Gly Ile  Val Cys Ser Cys Pro  Glu Gly Leu 
    1190                 1195                 1200             


Gln Leu  Asn Lys Asp Asn Lys  Thr Cys Glu Ile Val  Asp Tyr Cys 
    1205                 1210                 1215             


Ser Asn  His Leu Lys Cys Ser  Gln Val Cys Glu Gln  His Lys His 
    1220                 1225                 1230             


Thr Val  Lys Cys Ser Cys Tyr  Glu Gly Trp Lys Leu  Asp Val Asp 
    1235                 1240                 1245             


Gly Glu  Ser Cys Thr Ser Val  Asp Pro Phe Glu Ala  Phe Ile Ile 
    1250                 1255                 1260             


Phe Ser  Ile Arg His Glu Ile  Arg Arg Ile Asp Leu  His Lys Arg 
    1265                 1270                 1275             


Asp Tyr  Ser Leu Leu Val Pro  Gly Leu Arg Asn Thr  Ile Ala Leu 
    1280                 1285                 1290             


Asp Phe  His Phe Asn Gln Ser  Leu Leu Tyr Trp Thr  Asp Val Val 
    1295                 1300                 1305             


Glu Asp  Arg Ile Tyr Arg Gly  Lys Leu Ser Glu Ser  Gly Gly Val 
    1310                 1315                 1320             


Ser Ala  Ile Glu Val Val Val  Glu His Gly Leu Ala  Thr Pro Glu 
    1325                 1330                 1335             


Gly Leu  Thr Val Asp Trp Ile  Ala Gly Asn Ile Tyr  Trp Ile Asp 
    1340                 1345                 1350             


Ser Asn  Leu Asp Gln Ile Glu  Val Ala Lys Leu Asp  Gly Ser Leu 
    1355                 1360                 1365             


Arg Thr  Thr Leu Ile Ala Gly  Ala Met Glu His Pro  Arg Ala Ile 
    1370                 1375                 1380             


Ala Leu  Asp Pro Arg Tyr Gly  Ile Leu Phe Trp Thr  Asp Trp Asp 
    1385                 1390                 1395             


Ala Asn  Phe Pro Arg Ile Glu  Ser Ala Ser Met Ser  Gly Ala Gly 
    1400                 1405                 1410             


Arg Lys  Thr Ile Tyr Lys Asp  Met Lys Thr Gly Ala  Trp Pro Asn 
    1415                 1420                 1425             


Gly Leu  Thr Val Asp His Phe  Glu Lys Arg Ile Val  Trp Thr Asp 
    1430                 1435                 1440             


Ala Arg  Ser Asp Ala Ile Tyr  Ser Ala Leu Tyr Asp  Gly Thr Asn 
    1445                 1450                 1455             


Met Ile  Glu Ile Ile Arg Gly  His Glu Tyr Leu Ser  His Pro Phe 
    1460                 1465                 1470             


Ala Val  Ser Leu Tyr Gly Ser  Glu Val Tyr Trp Thr  Asp Trp Arg 
    1475                 1480                 1485             


Thr Asn  Thr Leu Ser Lys Ala  Asn Lys Trp Thr Gly  Gln Asn Val 
    1490                 1495                 1500             


Ser Val  Ile Gln Lys Thr Ser  Ala Gln Pro Phe Asp  Leu Gln Ile 
    1505                 1510                 1515             


Tyr His  Pro Ser Arg Gln Pro  Gln Ala Pro Asn Pro  Cys Ala Ala 
    1520                 1525                 1530             


Asn Asp  Gly Lys Gly Pro Cys  Ser His Met Cys Leu  Ile Asn His 
    1535                 1540                 1545             


Asn Arg  Ser Ala Ala Cys Ala  Cys Pro His Leu Met  Lys Leu Ser 
    1550                 1555                 1560             


Ser Asp  Lys Lys Thr Cys Tyr  Glu Met Lys Lys Phe  Leu Leu Tyr 
    1565                 1570                 1575             


Ala Arg  Arg Ser Glu Ile Arg  Gly Val Asp Ile Asp  Asn Pro Tyr 
    1580                 1585                 1590             


Phe Asn  Phe Ile Thr Ala Phe  Thr Val Pro Asp Ile  Asp Asp Val 
    1595                 1600                 1605             


Thr Val  Ile Asp Phe Asp Ala  Ser Glu Glu Arg Leu  Tyr Trp Thr 
    1610                 1615                 1620             


Asp Ile  Lys Thr Gln Thr Ile  Lys Arg Ala Phe Ile  Asn Gly Thr 
    1625                 1630                 1635             


Gly Leu  Glu Thr Val Ile Ser  Arg Asp Ile Gln Ser  Ile Arg Gly 
    1640                 1645                 1650             


Leu Ala  Val Asp Trp Val Ser  Arg Asn Leu Tyr Trp  Ile Ser Ser 
    1655                 1660                 1665             


Glu Phe  Asp Glu Thr Gln Ile  Asn Val Ala Arg Leu  Asp Gly Ser 
    1670                 1675                 1680             


Leu Lys  Thr Ser Ile Ile His  Gly Ile Asp Lys Pro  Gln Cys Leu 
    1685                 1690                 1695             


Ala Ala  His Pro Val Arg Gly  Lys Leu Tyr Trp Thr  Asp Gly Asn 
    1700                 1705                 1710             


Thr Ile  Asn Met Ala Asn Met  Asp Gly Ser Asn Ser  Lys Ile Leu 
    1715                 1720                 1725             


Phe Gln  Asn Gln Lys Glu Pro  Val Gly Leu Ser Ile  Asp Tyr Val 
    1730                 1735                 1740             


Glu Asn  Lys Leu Tyr Trp Ile  Ser Ser Gly Asn Gly  Thr Ile Asn 
    1745                 1750                 1755             


Arg Cys  Asn Leu Asp Gly Gly  Asn Leu Glu Val Ile  Glu Ser Met 
    1760                 1765                 1770             


Lys Glu  Glu Leu Thr Lys Ala  Thr Ala Leu Thr Ile  Met Asp Lys 
    1775                 1780                 1785             


Lys Leu  Trp Trp Ala Asp Gln  Asn Leu Ala Gln Leu  Gly Thr Cys 
    1790                 1795                 1800             


Ser Lys  Arg Asp Gly Arg Asn  Pro Thr Ile Leu Arg  Asn Lys Thr 
    1805                 1810                 1815             


Ser Gly  Val Val His Met Lys  Val Tyr Asp Lys Glu  Ala Gln Gln 
    1820                 1825                 1830             


Gly Ser  Asn Ser Cys Gln Leu  Asn Asn Gly Gly Cys  Ser Gln Leu 
    1835                 1840                 1845             


Cys Leu  Pro Thr Ser Glu Thr  Thr Arg Thr Cys Met  Cys Thr Val 
    1850                 1855                 1860             


Gly Tyr  Tyr Leu Gln Lys Asn  Arg Met Ser Cys Gln  Gly Ile Glu 
    1865                 1870                 1875             


Ser Phe  Leu Met Tyr Ser Val  His Glu Gly Ile Arg  Gly Ile Pro 
    1880                 1885                 1890             


Leu Glu  Pro Ser Asp Lys Met  Asp Ala Leu Met Pro  Ile Ser Gly 
    1895                 1900                 1905             


Thr Ser  Phe Ala Val Gly Ile  Asp Phe His Ala Glu  Asn Asp Thr 
    1910                 1915                 1920             


Ile Tyr  Trp Thr Asp Met Gly  Phe Asn Lys Ile Ser  Arg Ala Lys 
    1925                 1930                 1935             


Arg Asp  Gln Thr Trp Lys Glu  Asp Ile Ile Thr Asn  Gly Leu Gly 
    1940                 1945                 1950             


Arg Val  Glu Gly Ile Ala Val  Asp Trp Ile Ala Gly  Asn Ile Tyr 
    1955                 1960                 1965             


Trp Thr  Asp His Gly Phe Asn  Leu Ile Glu Val Ala  Arg Leu Asn 
    1970                 1975                 1980             


Gly Ser  Phe Arg Tyr Val Ile  Ile Ser Gln Gly Leu  Asp Gln Pro 
    1985                 1990                 1995             


Arg Ser  Ile Ala Val His Pro  Glu Lys Gly Leu Leu  Phe Trp Thr 
    2000                 2005                 2010             


Glu Trp  Gly Gln Met Pro Cys  Ile Gly Lys Ala Arg  Leu Asp Gly 
    2015                 2020                 2025             


Ser Glu  Lys Val Val Leu Val  Ser Met Gly Ile Ala  Trp Pro Asn 
    2030                 2035                 2040             


Gly Ile  Ser Ile Asp Tyr Glu  Glu Asn Lys Leu Tyr  Trp Cys Asp 
    2045                 2050                 2055             


Ala Arg  Thr Asp Lys Ile Glu  Arg Ile Asp Leu Glu  Thr Gly Gly 
    2060                 2065                 2070             


Asn Arg  Glu Met Val Leu Ser  Gly Ser Asn Val Asp  Met Phe Ser 
    2075                 2080                 2085             


Val Ala  Val Phe Gly Ala Tyr  Ile Tyr Trp Ser Asp  Arg Ala His 
    2090                 2095                 2100             


Ala Asn  Gly Ser Val Arg Arg  Gly His Lys Asn Asp  Ala Thr Glu 
    2105                 2110                 2115             


Thr Ile  Thr Met Arg Thr Gly  Leu Gly Val Asn Leu  Lys Glu Val 
    2120                 2125                 2130             


Lys Ile  Phe Asn Arg Val Arg  Glu Lys Gly Thr Asn  Val Cys Ala 
    2135                 2140                 2145             


Arg Asp  Asn Gly Gly Cys Lys  Gln Leu Cys Leu Tyr  Arg Gly Asn 
    2150                 2155                 2160             


Ser Arg  Arg Thr Cys Ala Cys  Ala His Gly Tyr Leu  Ala Glu Asp 
    2165                 2170                 2175             


Gly Val  Thr Cys Leu Arg His  Glu Gly Tyr Leu Leu  Tyr Ser Gly 
    2180                 2185                 2190             


Arg Thr  Ile Leu Lys Ser Ile  His Leu Ser Asp Glu  Thr Asn Leu 
    2195                 2200                 2205             


Asn Ser  Pro Ile Arg Pro Tyr  Glu Asn Pro Arg Tyr  Phe Lys Asn 
    2210                 2215                 2220             


Val Ile  Ala Leu Ala Phe Asp  Tyr Asn Gln Arg Arg  Lys Gly Thr 
    2225                 2230                 2235             


Asn Arg  Ile Phe Tyr Ser Asp  Ala His Phe Gly Asn  Ile Gln Leu 
    2240                 2245                 2250             


Ile Lys  Asp Asn Trp Glu Asp  Arg Gln Val Ile Val  Glu Asn Val 
    2255                 2260                 2265             


Gly Ser  Val Glu Gly Leu Ala  Tyr His Arg Ala Trp  Asp Thr Leu 
    2270                 2275                 2280             


Tyr Trp  Thr Ser Ser Thr Thr  Ser Ser Ile Thr Arg  His Thr Val 
    2285                 2290                 2295             


Asp Gln  Thr Arg Pro Gly Ala  Phe Asp Arg Glu Ala  Val Ile Thr 
    2300                 2305                 2310             


Met Ser  Glu Asp Asp His Pro  His Val Leu Ala Leu  Asp Glu Cys 
    2315                 2320                 2325             


Gln Asn  Leu Met Phe Trp Thr  Asn Trp Asn Glu Gln  His Pro Ser 
    2330                 2335                 2340             


Ile Met  Arg Ser Thr Leu Thr  Gly Lys Asn Ala Gln  Val Val Val 
    2345                 2350                 2355             


Ser Thr  Asp Ile Leu Thr Pro  Asn Gly Leu Thr Ile  Asp Tyr Arg 
    2360                 2365                 2370             


Ala Glu  Lys Leu Tyr Phe Ser  Asp Gly Ser Leu Gly  Lys Ile Glu 
    2375                 2380                 2385             


Arg Cys  Glu Tyr Asp Gly Ser  Gln Arg His Val Ile  Val Lys Ser 
    2390                 2395                 2400             


Gly Pro  Gly Thr Phe Leu Ser  Leu Ala Val Tyr Asp  Asn Tyr Ile 
    2405                 2410                 2415             


Phe Trp  Ser Asp Trp Gly Arg  Arg Ala Ile Leu Arg  Ser Asn Lys 
    2420                 2425                 2430             


Tyr Thr  Gly Gly Asp Thr Lys  Ile Leu Arg Ser Asp  Ile Pro His 
    2435                 2440                 2445             


Gln Pro  Met Gly Ile Ile Ala  Val Ala Asn Asp Thr  Asn Ser Cys 
    2450                 2455                 2460             


Glu Leu  Ser Pro Cys Ala Leu  Leu Asn Gly Gly Cys  His Asp Leu 
    2465                 2470                 2475             


Cys Leu  Leu Thr Pro Asn Gly  Arg Val Asn Cys Ser  Cys Arg Gly 
    2480                 2485                 2490             


Asp Arg  Ile Leu Leu Glu Asp  Asn Arg Cys Val Thr  Lys Asn Ser 
    2495                 2500                 2505             


Ser Cys  Asn Ala Tyr Ser Glu  Phe Glu Cys Gly Asn  Gly Glu Cys 
    2510                 2515                 2520             


Ile Asp  Tyr Gln Leu Thr Cys  Asp Gly Ile Pro His  Cys Lys Asp 
    2525                 2530                 2535             


Lys Ser  Asp Glu Lys Leu Leu  Tyr Cys Glu Asn Arg  Ser Cys Arg 
    2540                 2545                 2550             


Arg Gly  Phe Lys Pro Cys Tyr  Asn Arg Arg Cys Ile  Pro His Gly 
    2555                 2560                 2565             


Lys Leu  Cys Asp Gly Glu Asn  Asp Cys Gly Asp Asn  Ser Asp Glu 
    2570                 2575                 2580             


Leu Asp  Cys Lys Val Ser Thr  Cys Ala Thr Val Glu  Phe Arg Cys 
    2585                 2590                 2595             


Ala Asp  Gly Thr Cys Ile Pro  Arg Ser Ala Arg Cys  Asn Gln Asn 
    2600                 2605                 2610             


Ile Asp  Cys Ala Asp Ala Ser  Asp Glu Lys Asn Cys  Asn Asn Thr 
    2615                 2620                 2625             


Asp Cys  Thr His Phe Tyr Lys  Leu Gly Val Lys Thr  Thr Gly Phe 
    2630                 2635                 2640             


Ile Arg  Cys Asn Ser Thr Ser  Leu Cys Val Leu Pro  Thr Trp Ile 
    2645                 2650                 2655             


Cys Asp  Gly Ser Asn Asp Cys  Gly Asp Tyr Ser Asp  Glu Leu Lys 
    2660                 2665                 2670             


Cys Pro  Val Gln Asn Lys His  Lys Cys Glu Glu Asn  Tyr Phe Ser 
    2675                 2680                 2685             


Cys Pro  Ser Gly Arg Cys Ile  Leu Asn Thr Trp Ile  Cys Asp Gly 
    2690                 2695                 2700             


Gln Lys  Asp Cys Glu Asp Gly  Arg Asp Glu Phe His  Cys Asp Ser 
    2705                 2710                 2715             


Ser Cys  Ser Trp Asn Gln Phe  Ala Cys Ser Ala Gln  Lys Cys Ile 
    2720                 2725                 2730             


Ser Lys  His Trp Ile Cys Asp  Gly Glu Asp Asp Cys  Gly Asp Gly 
    2735                 2740                 2745             


Leu Asp  Glu Ser Asp Ser Ile  Cys Gly Ala Ile Thr  Cys Ala Ala 
    2750                 2755                 2760             


Asp Met  Phe Ser Cys Gln Gly  Ser Arg Ala Cys Val  Pro Arg His 
    2765                 2770                 2775             


Trp Leu  Cys Asp Gly Glu Arg  Asp Cys Pro Asp Gly  Ser Asp Glu 
    2780                 2785                 2790             


Leu Ser  Thr Ala Gly Cys Ala  Pro Asn Asn Thr Cys  Asp Glu Asn 
    2795                 2800                 2805             


Ala Phe  Met Cys His Asn Lys  Val Cys Ile Pro Lys  Gln Phe Val 
    2810                 2815                 2820             


Cys Asp  His Asp Asp Asp Cys  Gly Asp Gly Ser Asp  Glu Ser Pro 
    2825                 2830                 2835             


Gln Cys  Gly Tyr Arg Gln Cys  Gly Thr Glu Glu Phe  Ser Cys Ala 
    2840                 2845                 2850             


Asp Gly  Arg Cys Leu Leu Asn  Thr Gln Trp Gln Cys  Asp Gly Asp 
    2855                 2860                 2865             


Phe Asp  Cys Pro Asp His Ser  Asp Glu Ala Pro Leu  Asn Pro Lys 
    2870                 2875                 2880             


Cys Lys  Ser Ala Glu Gln Ser  Cys Asn Ser Ser Phe  Phe Met Cys 
    2885                 2890                 2895             


Lys Asn  Gly Arg Cys Ile Pro  Ser Gly Gly Leu Cys  Asp Asn Lys 
    2900                 2905                 2910             


Asp Asp  Cys Gly Asp Gly Ser  Asp Glu Arg Asn Cys  His Ile Asn 
    2915                 2920                 2925             


Glu Cys  Leu Ser Lys Lys Val  Ser Gly Cys Ser Gln  Asp Cys Gln 
    2930                 2935                 2940             


Asp Leu  Pro Val Ser Tyr Lys  Cys Lys Cys Trp Pro  Gly Phe Gln 
    2945                 2950                 2955             


Leu Lys  Asp Asp Gly Lys Thr  Cys Val Asp Ile Asp  Glu Cys Ser 
    2960                 2965                 2970             


Ser Gly  Phe Pro Cys Ser Gln  Gln Cys Ile Asn Thr  Tyr Gly Thr 
    2975                 2980                 2985             


Tyr Lys  Cys Leu Cys Thr Asp  Gly Tyr Glu Ile Gln  Pro Asp Asn 
    2990                 2995                 3000             


Pro Asn  Gly Cys Lys Ser Leu  Ser Asp Glu Glu Pro  Phe Leu Ile 
    3005                 3010                 3015             


Leu Ala  Asp His His Glu Ile  Arg Lys Ile Ser Thr  Asp Gly Ser 
    3020                 3025                 3030             


Asn Tyr  Thr Leu Leu Lys Gln  Gly Leu Asn Asn Val  Ile Ala Ile 
    3035                 3040                 3045             


Asp Phe  Asp Tyr Arg Glu Glu  Phe Ile Tyr Trp Ile  Asp Ser Ser 
    3050                 3055                 3060             


Arg Pro  Asn Gly Ser Arg Ile  Asn Arg Met Cys Leu  Asn Gly Ser 
    3065                 3070                 3075             


Asp Ile  Lys Val Val His Asn  Thr Ala Val Pro Asn  Ala Leu Ala 
    3080                 3085                 3090             


Val Asp  Trp Ile Gly Lys Asn  Leu Tyr Trp Ser Asp  Thr Glu Lys 
    3095                 3100                 3105             


Arg Ile  Ile Glu Val Ser Lys  Leu Asn Gly Leu Tyr  Pro Thr Ile 
    3110                 3115                 3120             


Leu Val  Ser Lys Arg Leu Lys  Phe Pro Arg Asp Leu  Ser Leu Asp 
    3125                 3130                 3135             


Pro Gln  Ala Gly Tyr Leu Tyr  Trp Ile Asp Cys Cys  Glu Tyr Pro 
    3140                 3145                 3150             


His Ile  Gly Arg Val Gly Met  Asp Gly Thr Asn Gln  Ser Val Val 
    3155                 3160                 3165             


Ile Glu  Thr Lys Ile Ser Arg  Pro Met Ala Leu Thr  Ile Asp Tyr 
    3170                 3175                 3180             


Val Asn  Arg Arg Leu Tyr Trp  Ala Asp Glu Asn His  Ile Glu Phe 
    3185                 3190                 3195             


Ser Asn  Met Asp Gly Ser His  Arg His Lys Val Pro  Asn Gln Asp 
    3200                 3205                 3210             


Ile Pro  Gly Val Ile Ala Leu  Thr Leu Phe Glu Asp  Tyr Ile Tyr 
    3215                 3220                 3225             


Trp Thr  Asp Gly Lys Thr Lys  Ser Leu Ser Arg Ala  His Lys Thr 
    3230                 3235                 3240             


Ser Gly  Ala Asp Arg Leu Ser  Leu Ile Tyr Ser Trp  His Ala Ile 
    3245                 3250                 3255             


Thr Asp  Ile Gln Val Tyr His  Ser Tyr Arg Gln Pro  Asp Val Ser 
    3260                 3265                 3270             


Lys His  Leu Cys Met Ile Asn  Asn Gly Gly Cys Ser  His Leu Cys 
    3275                 3280                 3285             


Leu Leu  Ala Pro Gly Lys Thr  His Thr Cys Ala Cys  Pro Thr Asn 
    3290                 3295                 3300             


Phe Tyr  Leu Ala Ala Asp Asn  Arg Thr Cys Leu Ser  Asn Cys Thr 
    3305                 3310                 3315             


Ala Ser  Gln Phe Arg Cys Lys  Thr Asp Lys Cys Ile  Pro Phe Trp 
    3320                 3325                 3330             


Trp Lys  Cys Asp Thr Val Asp  Asp Cys Gly Asp Gly  Ser Asp Glu 
    3335                 3340                 3345             


Pro Asp  Asp Cys Pro Glu Phe  Arg Cys Gln Pro Gly  Arg Phe Gln 
    3350                 3355                 3360             


Cys Gly  Thr Gly Leu Cys Ala  Leu Pro Ala Phe Ile  Cys Asp Gly 
    3365                 3370                 3375             


Glu Asn  Asp Cys Gly Asp Asn  Ser Asp Glu Leu Asn  Cys Asp Thr 
    3380                 3385                 3390             


His Val  Cys Leu Ser Gly Gln  Phe Lys Cys Thr Lys  Asn Gln Lys 
    3395                 3400                 3405             


Cys Ile  Pro Val Asn Leu Arg  Cys Asn Gly Gln Asp  Asp Cys Gly 
    3410                 3415                 3420             


Asp Glu  Glu Asp Glu Arg Asp  Cys Pro Glu Asn Ser  Cys Ser Pro 
    3425                 3430                 3435             


Asp Tyr  Phe Gln Cys Lys Thr  Thr Lys His Cys Ile  Ser Lys Leu 
    3440                 3445                 3450             


Trp Val  Cys Asp Glu Asp Pro  Asp Cys Ala Asp Ala  Ser Asp Glu 
    3455                 3460                 3465             


Ala Asn  Cys Asp Lys Lys Thr  Cys Gly Pro His Glu  Phe Gln Cys 
    3470                 3475                 3480             


Lys Asn  Asn Asn Cys Ile Pro  Asp His Trp Arg Cys  Asp Ser Gln 
    3485                 3490                 3495             


Asn Asp  Cys Ser Asp Asn Ser  Asp Glu Glu Asn Cys  Lys Pro Gln 
    3500                 3505                 3510             


Thr Cys  Thr Leu Lys Asp Phe  Leu Cys Ala Asn Gly  Asp Cys Val 
    3515                 3520                 3525             


Ser Ser  Arg Phe Trp Cys Asp  Gly Asp Phe Asp Cys  Ala Asp Gly 
    3530                 3535                 3540             


Ser Asp  Glu Arg Asn Cys Glu  Thr Ser Cys Ser Lys  Asp Gln Phe 
    3545                 3550                 3555             


Arg Cys  Ser Asn Gly Gln Cys  Ile Pro Ala Lys Trp  Lys Cys Asp 
    3560                 3565                 3570             


Gly His  Glu Asp Cys Lys Tyr  Gly Glu Asp Glu Lys  Ser Cys Glu 
    3575                 3580                 3585             


Pro Ala  Ser Pro Thr Cys Ser  Ser Arg Glu Tyr Ile  Cys Ala Ser 
    3590                 3595                 3600             


Asp Gly  Cys Ile Ser Ala Ser  Leu Lys Cys Asn Gly  Glu Tyr Asp 
    3605                 3610                 3615             


Cys Ala  Asp Gly Ser Asp Glu  Met Asp Cys Val Thr  Glu Cys Lys 
    3620                 3625                 3630             


Glu Asp  Gln Phe Arg Cys Lys  Asn Lys Ala His Cys  Ile Pro Ile 
    3635                 3640                 3645             


Arg Trp  Leu Cys Asp Gly Ile  His Asp Cys Val Asp  Gly Ser Asp 
    3650                 3655                 3660             


Glu Glu  Asn Cys Glu Arg Gly  Gly Asn Ile Cys Arg  Ala Asp Glu 
    3665                 3670                 3675             


Phe Leu  Cys Asn Asn Ser Leu  Cys Lys Leu His Phe  Trp Val Cys 
    3680                 3685                 3690             


Asp Gly  Glu Asp Asp Cys Gly  Asp Asn Ser Asp Glu  Ala Pro Asp 
    3695                 3700                 3705             


Met Cys  Val Lys Phe Leu Cys  Pro Ser Thr Arg Pro  His Arg Cys 
    3710                 3715                 3720             


Arg Asn  Asn Arg Ile Cys Leu  Gln Ser Glu Gln Met  Cys Asn Gly 
    3725                 3730                 3735             


Ile Asp  Glu Cys Gly Asp Asn  Ser Asp Glu Asp His  Cys Gly Gly 
    3740                 3745                 3750             


Lys Leu  Thr Tyr Lys Ala Arg  Pro Cys Lys Lys Asp  Glu Phe Ala 
    3755                 3760                 3765             


Cys Ser  Asn Lys Lys Cys Ile  Pro Met Asp Leu Gln  Cys Asp Arg 
    3770                 3775                 3780             


Leu Asp  Asp Cys Gly Asp Gly  Ser Asp Glu Gln Gly  Cys Arg Ile 
    3785                 3790                 3795             


Ala Pro  Thr Glu Tyr Thr Cys  Glu Asp Asn Val Asn  Pro Cys Gly 
    3800                 3805                 3810             


Asp Asp  Ala Tyr Cys Asn Gln  Ile Lys Thr Ser Val  Phe Cys Arg 
    3815                 3820                 3825             


Cys Lys  Pro Gly Phe Gln Arg  Asn Met Lys Asn Arg  Gln Cys Glu 
    3830                 3835                 3840             


Asp Leu  Asn Glu Cys Leu Val  Phe Gly Thr Cys Ser  His Gln Cys 
    3845                 3850                 3855             


Ile Asn  Val Glu Gly Ser Tyr  Lys Cys Val Cys Asp  Gln Asn Phe 
    3860                 3865                 3870             


Gln Glu  Arg Asn Asn Thr Cys  Ile Ala Glu Gly Ser  Glu Asp Gln 
    3875                 3880                 3885             


Val Leu  Tyr Ile Ala Asn Asp  Thr Asp Ile Leu Gly  Phe Ile Tyr 
    3890                 3895                 3900             


Pro Phe  Asn Tyr Ser Gly Asp  His Gln Gln Ile Ser  His Ile Glu 
    3905                 3910                 3915             


His Asn  Ser Arg Ile Thr Gly  Met Asp Val Tyr Tyr  Gln Arg Asp 
    3920                 3925                 3930             


Met Ile  Ile Trp Ser Thr Gln  Phe Asn Pro Gly Gly  Ile Phe Tyr 
    3935                 3940                 3945             


Lys Arg  Ile His Gly Arg Glu  Lys Arg Gln Ala Asn  Ser Gly Leu 
    3950                 3955                 3960             


Ile Cys  Pro Glu Phe Lys Arg  Pro Arg Asp Ile Ala  Val Asp Trp 
    3965                 3970                 3975             


Val Ala  Gly Asn Ile Tyr Trp  Thr Asp His Ser Arg  Met His Trp 
    3980                 3985                 3990             


Phe Ser  Tyr Tyr Thr Thr His  Trp Thr Ser Leu Arg  Tyr Ser Ile 
    3995                 4000                 4005             


Asn Val  Gly Gln Leu Asn Gly  Pro Asn Cys Thr Arg  Leu Leu Thr 
    4010                 4015                 4020             


Asn Met  Ala Gly Glu Pro Tyr  Ala Ile Ala Val Asn  Pro Lys Arg 
    4025                 4030                 4035             


Gly Met  Met Tyr Trp Thr Val  Val Gly Asp His Ser  His Ile Glu 
    4040                 4045                 4050             


Glu Ala  Ala Met Asp Gly Thr  Leu Arg Arg Ile Leu  Val Gln Lys 
    4055                 4060                 4065             


Asn Leu  Gln Arg Pro Thr Gly  Leu Ala Val Asp Tyr  Phe Ser Glu 
    4070                 4075                 4080             


Arg Ile  Tyr Trp Ala Asp Phe  Glu Leu Ser Ile Ile  Gly Ser Val 
    4085                 4090                 4095             


Leu Tyr  Asp Gly Ser Asn Ser  Val Val Ser Val Ser  Ser Lys Gln 
    4100                 4105                 4110             


Gly Leu  Leu His Pro His Arg  Ile Asp Ile Phe Glu  Asp Tyr Ile 
    4115                 4120                 4125             


Tyr Gly  Ala Gly Pro Lys Asn  Gly Val Phe Arg Val  Gln Lys Phe 
    4130                 4135                 4140             


Gly His  Gly Ser Val Glu Tyr  Leu Ala Leu Asn Ile  Asp Lys Thr 
    4145                 4150                 4155             


Lys Gly  Val Leu Ile Ser His  Arg Tyr Lys Gln Leu  Asp Leu Pro 
    4160                 4165                 4170             


Asn Pro  Cys Leu Asp Leu Ala  Cys Glu Phe Leu Cys  Leu Leu Asn 
    4175                 4180                 4185             


Pro Ser  Gly Ala Thr Cys Val  Cys Pro Glu Gly Lys  Tyr Leu Ile 
    4190                 4195                 4200             


Asn Gly  Thr Cys Asn Asp Asp  Ser Leu Leu Asp Asp  Ser Cys Lys 
    4205                 4210                 4215             


Leu Thr  Cys Glu Asn Gly Gly  Arg Cys Ile Leu Asn  Glu Lys Gly 
    4220                 4225                 4230             


Asp Leu  Arg Cys His Cys Trp  Pro Ser Tyr Ser Gly  Glu Arg Cys 
    4235                 4240                 4245             


Glu Val  Asn His Cys Ser Asn  Tyr Cys Gln Asn Gly  Gly Thr Cys 
    4250                 4255                 4260             


Val Pro  Ser Val Leu Gly Arg  Pro Thr Cys Ser Cys  Ala Leu Gly 
    4265                 4270                 4275             


Phe Thr  Gly Pro Asn Cys Gly  Lys Thr Val Cys Glu  Asp Phe Cys 
    4280                 4285                 4290             


Gln Asn  Gly Gly Thr Cys Ile  Val Thr Ala Gly Asn  Gln Pro Tyr 
    4295                 4300                 4305             


Cys His  Cys Gln Pro Glu Tyr  Thr Gly Asp Arg Cys  Gln Tyr Tyr 
    4310                 4315                 4320             


Val Cys  His His Tyr Cys Val  Asn Ser Glu Ser Cys  Thr Ile Gly 
    4325                 4330                 4335             


Asp Asp  Gly Ser Val Glu Cys  Val Cys Pro Thr Arg  Tyr Glu Gly 
    4340                 4345                 4350             


Pro Lys  Cys Glu Val Asp Lys  Cys Val Arg Cys His  Gly Gly His 
    4355                 4360                 4365             


Cys Ile  Ile Asn Lys Asp Ser  Glu Asp Ile Phe Cys  Asn Cys Thr 
    4370                 4375                 4380             


Asn Gly  Lys Ile Ala Ser Ser  Cys Gln Leu Cys Asp  Gly Tyr Cys 
    4385                 4390                 4395             


Tyr Asn  Gly Gly Thr Cys Gln  Leu Asp Pro Glu Thr  Asn Val Pro 
    4400                 4405                 4410             


Val Cys  Leu Cys Ser Thr Asn  Trp Ser Gly Thr Gln  Cys Glu Arg 
    4415                 4420                 4425             


Pro Ala  Pro Lys Ser Ser Lys  Ser Asp His Ile Ser  Thr Arg Ser 
    4430                 4435                 4440             


Ile Ala  Ile Ile Val Pro Leu  Val Leu Leu Val Thr  Leu Ile Thr 
    4445                 4450                 4455             


Thr Leu  Val Ile Gly Leu Val  Leu Cys Lys Arg Lys  Arg Arg Thr 
    4460                 4465                 4470             


Lys Thr  Ile Arg Arg Gln Pro  Ile Ile Asn Gly Gly  Ile Asn Val 
    4475                 4480                 4485             


Glu Ile  Gly Asn Pro Ser Tyr  Asn Met Tyr Glu Val  Asp His Asp 
    4490                 4495                 4500             


His Asn  Asp Gly Gly Leu Leu  Asp Pro Gly Phe Met  Ile Asp Pro 
    4505                 4510                 4515             


Thr Lys  Ala Arg Tyr Ile Gly  Gly Gly Pro Ser Ala  Phe Lys Leu 
    4520                 4525                 4530             


Pro His  Thr Ala Pro Pro Ile  Tyr Leu Asn Ser Asp  Leu Lys Gly 
    4535                 4540                 4545             


Pro Leu  Thr Ala Gly Pro Thr  Asn Tyr Ser Asn Pro  Val Tyr Ala 
    4550                 4555                 4560             


Lys Leu  Tyr Met Asp Gly Gln  Asn Cys Arg Asn Ser  Leu Gly Ser 
    4565                 4570                 4575             


Val Asp  Glu Arg Lys Glu Leu  Leu Pro Lys Lys Ile  Glu Ile Gly 
    4580                 4585                 4590             


Ile Arg  Glu Thr Val Ala 
    4595                 


<210>  8013
<211>  782
<212>  PRT
<213>  Homo Sapiens

<400>  8013

Met Ser Glu Phe Leu Leu Ala Leu Leu Thr Leu Ser Gly Leu Leu Pro 
1               5                   10                  15      


Ile Ala Arg Val Leu Thr Val Gly Ala Asp Arg Asp Gln Gln Leu Cys 
            20                  25                  30          


Asp Pro Gly Glu Phe Leu Cys His Asp His Val Thr Cys Val Ser Gln 
        35                  40                  45              


Ser Trp Leu Cys Asp Gly Asp Pro Asp Cys Pro Asp Asp Ser Asp Glu 
    50                  55                  60                  


Ser Leu Asp Thr Ser Arg Thr Cys Gln Val Asp Gln Phe Ser Cys Gly 
65                  70                  75                  80  


Asn Gly Arg Cys Ile Pro Arg Ala Trp Leu Cys Asp Arg Glu Asp Asp 
                85                  90                  95      


Cys Gly Asp Gln Thr Asp Glu Met Ala Ser Cys Glu Phe Pro Thr Cys 
            100                 105                 110         


Glu Pro Leu Thr Gln Phe Val Cys Lys Ser Gly Arg Cys Ile Ser Ser 
        115                 120                 125             


Lys Trp His Cys Asp Ser Asp Asp Asp Cys Gly Asp Gly Ser Asp Glu 
    130                 135                 140                 


Val Gly Cys Val His Ser Cys Phe Asp Asn Gln Phe Arg Cys Ser Ser 
145                 150                 155                 160 


Gly Arg Cys Ile Pro Gly His Trp Ala Cys Asp Gly Asp Asn Asp Cys 
                165                 170                 175     


Gly Asp Phe Ser Asp Glu Ala Gln Ile Asn Cys Thr Lys Glu Glu Ile 
            180                 185                 190         


His Ser Pro Ala Gly Cys Asn Gly Asn Glu Phe Gln Cys His Pro Asp 
        195                 200                 205             


Gly Asn Cys Val Pro Asp Leu Trp Arg Cys Asp Gly Glu Lys Asp Cys 
    210                 215                 220                 


Glu Asp Gly Ser Asp Glu Lys Gly Cys Asn Gly Thr Ile Arg Leu Cys 
225                 230                 235                 240 


Asp His Lys Thr Lys Phe Ser Cys Trp Ser Thr Gly Arg Cys Ile Asn 
                245                 250                 255     


Lys Ala Trp Val Cys Asp Gly Asp Ile Asp Cys Glu Asp Gln Ser Asp 
            260                 265                 270         


Glu Asp Asp Cys Asp Ser Phe Leu Cys Gly Pro Pro Lys His Pro Cys 
        275                 280                 285             


Ala Asn Asp Thr Ser Val Cys Leu Gln Pro Glu Lys Leu Cys Asn Gly 
    290                 295                 300                 


Lys Lys Asp Cys Pro Asp Gly Ser Asp Glu Gly Tyr Leu Cys Asp Glu 
305                 310                 315                 320 


Cys Ser Leu Asn Asn Gly Gly Cys Ser Asn His Cys Ser Val Val Pro 
                325                 330                 335     


Gly Arg Gly Ile Val Cys Ser Cys Pro Glu Gly Leu Gln Leu Asn Lys 
            340                 345                 350         


Asp Asn Lys Thr Cys Glu Ile Val Asp Tyr Cys Ser Asn His Leu Lys 
        355                 360                 365             


Cys Ser Gln Val Cys Glu Gln His Lys His Thr Val Lys Cys Ser Cys 
    370                 375                 380                 


Tyr Glu Gly Trp Lys Leu Asp Val Asp Gly Glu Ser Cys Thr Ser Val 
385                 390                 395                 400 


Asp Pro Phe Glu Ala Phe Ile Ile Phe Ser Ile Arg His Glu Ile Arg 
                405                 410                 415     


Arg Ile Asp Leu His Lys Arg Asp Tyr Ser Leu Leu Val Pro Gly Leu 
            420                 425                 430         


Arg Asn Thr Ile Ala Leu Asp Phe His Phe Asn Gln Ser Leu Leu Tyr 
        435                 440                 445             


Trp Thr Asp Val Val Glu Asp Arg Ile Tyr Arg Gly Lys Leu Ser Glu 
    450                 455                 460                 


Ser Gly Gly Val Ser Ala Ile Glu Val Val Val Glu His Gly Leu Ala 
465                 470                 475                 480 


Thr Pro Glu Gly Leu Thr Val Asp Trp Ile Ala Gly Asn Ile Tyr Trp 
                485                 490                 495     


Ile Asp Ser Asn Leu Asp Gln Ile Glu Val Ala Lys Leu Asp Gly Ser 
            500                 505                 510         


Leu Arg Thr Thr Leu Ile Ala Gly Ala Met Glu His Pro Arg Ala Ile 
        515                 520                 525             


Ala Leu Asp Pro Arg Tyr Gly Ile Leu Phe Trp Thr Asp Trp Asp Ala 
    530                 535                 540                 


Asn Phe Pro Arg Ile Glu Ser Ala Ser Met Ser Gly Ala Gly Arg Lys 
545                 550                 555                 560 


Thr Ile Tyr Lys Asp Met Lys Thr Gly Ala Trp Pro Asn Gly Leu Thr 
                565                 570                 575     


Val Asp His Phe Glu Lys Arg Ile Val Trp Thr Asp Ala Arg Ser Asp 
            580                 585                 590         


Ala Ile Tyr Ser Ala Leu Tyr Asp Gly Thr Asn Met Ile Glu Ile Ile 
        595                 600                 605             


Arg Gly His Glu Tyr Leu Ser His Pro Phe Ala Val Ser Leu Tyr Gly 
    610                 615                 620                 


Ser Glu Val Tyr Trp Thr Asp Trp Arg Thr Asn Thr Leu Ser Lys Ala 
625                 630                 635                 640 


Asn Lys Trp Thr Gly Gln Asn Val Ser Val Ile Gln Lys Thr Ser Ala 
                645                 650                 655     


Gln Pro Phe Asp Leu Gln Ile Tyr His Pro Ser Arg Gln Pro Gln Ala 
            660                 665                 670         


Pro Asn Pro Cys Ala Ala Asn Asp Gly Lys Gly Pro Cys Ser His Met 
        675                 680                 685             


Cys Leu Ile Asn His Asn Arg Ser Ala Ala Cys Ala Cys Pro His Leu 
    690                 695                 700                 


Met Lys Leu Ser Ser Asp Lys Lys Thr Cys Tyr Glu Met Lys Lys Phe 
705                 710                 715                 720 


Leu Leu Tyr Ala Arg Arg Ser Glu Ile Arg Gly Val Asp Ile Asp Asn 
                725                 730                 735     


Pro Tyr Phe Asn Phe Ile Thr Ala Phe Thr Val Pro Asp Ile Asp Asp 
            740                 745                 750         


Val Thr Val Ile Asp Phe Asp Ala Ser Glu Glu Arg Leu Tyr Trp Thr 
        755                 760                 765             


Asp Ile Lys Thr Gln Thr Ile Lys Arg Ala Phe Ile Asn Gly 
    770                 775                 780         


<210>  8014
<211>  280
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8014

Xaa Arg Pro Thr Cys Ser Cys Ala Leu Gly Phe Thr Gly Pro Asn Cys 
1               5                   10                  15      


Gly Lys Thr Val Cys Glu Asp Phe Cys Gln Asn Gly Gly Thr Cys Ile 
            20                  25                  30          


Val Thr Ala Gly Asn Gln Pro Tyr Cys His Cys Gln Pro Glu Tyr Thr 
        35                  40                  45              


Gly Asp Arg Cys Gln Tyr Tyr Val Cys His His Tyr Cys Val Asn Ser 
    50                  55                  60                  


Glu Ser Cys Thr Ile Gly Asp Asp Gly Ser Val Glu Cys Val Cys Pro 
65                  70                  75                  80  


Thr Arg Tyr Glu Gly Pro Lys Cys Glu Val Asp Lys Cys Val Arg Cys 
                85                  90                  95      


His Gly Gly His Cys Ile Ile Asn Lys Asp Ser Glu Asp Ile Phe Cys 
            100                 105                 110         


Asn Cys Thr Asn Gly Lys Ile Ala Ser Ser Cys Gln Leu Cys Asp Gly 
        115                 120                 125             


Tyr Cys Tyr Asn Gly Gly Thr Cys Gln Leu Asp Pro Glu Thr Asn Val 
    130                 135                 140                 


Pro Val Cys Leu Cys Ser Val Gly Phe Lys Ser Gln Arg Cys Asp Gln 
145                 150                 155                 160 


Lys Glu Asn Pro Cys Asp His Tyr Cys Gln Asn Glu Gly Ile Cys Thr 
                165                 170                 175     


Leu Thr Ala Phe Asn Glu Pro Arg Cys Lys Cys Ser Thr Asn Trp Ser 
            180                 185                 190         


Gly Thr Gln Cys Glu Arg Pro Ala Pro Lys Ser Ser Lys Ser Asp His 
        195                 200                 205             


Ile Ser Thr Arg Ser Ile Ala Ile Ile Val Pro Leu Val Leu Leu Val 
    210                 215                 220                 


Thr Leu Ile Thr Thr Leu Val Ile Gly Leu Val Leu Cys Lys Arg Lys 
225                 230                 235                 240 


Arg Arg Thr Lys Thr Ile Arg Arg Gln Pro Ile Ile Asn Gly Gly Ile 
                245                 250                 255     


Asn Val Glu Ile Gly Asn Pro Ser Tyr Asn Met Tyr Glu Val Asp His 
            260                 265                 270         


Asp His Asn Asp Gly Gly Leu Leu 
        275                 280 


<210>  8015
<211>  798
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8015

Xaa Ser Asn Lys Lys Cys Ile Pro Met Asp Leu Gln Cys Asp Arg Leu 
1               5                   10                  15      


Asp Asp Cys Gly Asp Gly Ser Asp Glu Gln Gly Cys Arg Ile Ala Pro 
            20                  25                  30          


Thr Glu Tyr Thr Cys Glu Asp Asn Val Asn Pro Cys Gly Asp Asp Ala 
        35                  40                  45              


Tyr Cys Asn Gln Ile Lys Thr Ser Val Phe Cys Arg Cys Lys Pro Gly 
    50                  55                  60                  


Phe Gln Arg Asn Met Lys Asn Arg Gln Cys Glu Asp Leu Asn Glu Cys 
65                  70                  75                  80  


Leu Val Phe Gly Thr Cys Ser His Gln Cys Ile Asn Val Glu Gly Ser 
                85                  90                  95      


Tyr Lys Cys Val Cys Asp Gln Asn Phe Gln Glu Arg Asn Asn Thr Cys 
            100                 105                 110         


Ile Ala Glu Gly Ser Glu Asp Gln Val Leu Tyr Ile Ala Asn Asp Thr 
        115                 120                 125             


Asp Ile Leu Gly Phe Ile Tyr Pro Phe Asn Tyr Ser Gly Asp His Gln 
    130                 135                 140                 


Gln Ile Ser His Ile Glu His Asn Ser Arg Ile Thr Gly Met Asp Val 
145                 150                 155                 160 


Tyr Tyr Gln Arg Asp Met Ile Ile Trp Ser Thr Gln Phe Asn Pro Gly 
                165                 170                 175     


Gly Ile Phe Tyr Lys Arg Ile His Gly Arg Glu Lys Arg Gln Ala Asn 
            180                 185                 190         


Ser Gly Leu Ile Cys Pro Glu Phe Lys Arg Pro Arg Asp Ile Ala Val 
        195                 200                 205             


Asp Trp Val Ala Gly Asn Ile Tyr Trp Thr Asp His Ser Arg Met His 
    210                 215                 220                 


Trp Phe Ser Tyr Tyr Thr Thr His Trp Thr Ser Leu Arg Tyr Ser Ile 
225                 230                 235                 240 


Asn Val Gly Gln Leu Asn Gly Pro Asn Cys Thr Arg Leu Leu Thr Asn 
                245                 250                 255     


Met Ala Gly Glu Pro Tyr Ala Ile Ala Val Asn Pro Lys Arg Gly Met 
            260                 265                 270         


Met Tyr Trp Thr Val Val Gly Asp His Ser His Ile Glu Glu Ala Ala 
        275                 280                 285             


Met Asp Gly Thr Leu Arg Arg Ile Leu Val Gln Lys Asn Leu Gln Arg 
    290                 295                 300                 


Pro Thr Gly Leu Ala Val Asp Tyr Phe Ser Glu Arg Ile Tyr Trp Ala 
305                 310                 315                 320 


Asp Phe Glu Leu Ser Ile Ile Gly Ser Val Leu Tyr Asp Gly Ser Asn 
                325                 330                 335     


Ser Val Val Ser Val Ser Ser Lys Gln Gly Leu Leu His Pro His Arg 
            340                 345                 350         


Ile Asp Ile Phe Glu Asp Tyr Ile Tyr Gly Ala Gly Pro Lys Asn Gly 
        355                 360                 365             


Val Phe Arg Val Gln Lys Phe Gly His Gly Ser Val Glu Tyr Leu Ala 
    370                 375                 380                 


Leu Asn Ile Asp Lys Thr Lys Gly Val Leu Ile Ser His Arg Tyr Lys 
385                 390                 395                 400 


Gln Leu Asp Leu Pro Asn Pro Cys Leu Asp Leu Ala Cys Glu Phe Leu 
                405                 410                 415     


Cys Leu Leu Asn Pro Ser Gly Ala Thr Cys Val Cys Pro Glu Gly Lys 
            420                 425                 430         


Tyr Leu Ile Asn Gly Thr Cys Asn Asp Asp Ser Leu Leu Asp Asp Ser 
        435                 440                 445             


Cys Lys Leu Thr Cys Glu Asn Gly Gly Arg Cys Ile Leu Asn Glu Lys 
    450                 455                 460                 


Gly Asp Leu Arg Cys His Cys Trp Pro Ser Tyr Ser Gly Glu Arg Cys 
465                 470                 475                 480 


Glu Val Asn His Cys Ser Asn Tyr Cys Gln Asn Gly Gly Thr Cys Val 
                485                 490                 495     


Pro Ser Val Leu Gly Arg Pro Thr Cys Ser Cys Ala Leu Gly Phe Thr 
            500                 505                 510         


Gly Pro Asn Cys Gly Lys Thr Val Cys Glu Asp Phe Cys Gln Asn Gly 
        515                 520                 525             


Gly Thr Cys Ile Val Thr Ala Gly Asn Gln Pro Tyr Cys His Cys Gln 
    530                 535                 540                 


Pro Glu Tyr Thr Gly Asp Arg Cys Gln Tyr Tyr Val Cys His His Tyr 
545                 550                 555                 560 


Cys Val Asn Ser Glu Ser Cys Thr Ile Gly Asp Asp Gly Ser Val Glu 
                565                 570                 575     


Cys Val Cys Pro Thr Arg Tyr Glu Gly Pro Lys Cys Glu Val Asp Lys 
            580                 585                 590         


Cys Val Arg Cys His Gly Gly His Cys Ile Ile Asn Lys Asp Ser Glu 
        595                 600                 605             


Asp Ile Phe Cys Asn Cys Thr Asn Gly Lys Ile Ala Ser Ser Cys Gln 
    610                 615                 620                 


Leu Cys Asp Gly Tyr Cys Tyr Asn Gly Gly Thr Cys Gln Leu Asp Pro 
625                 630                 635                 640 


Glu Thr Asn Val Pro Val Cys Leu Cys Ser Thr Asn Trp Ser Gly Thr 
                645                 650                 655     


Gln Cys Glu Arg Pro Ala Pro Lys Ser Ser Lys Ser Asp His Ile Ser 
            660                 665                 670         


Thr Arg Ser Ile Ala Ile Ile Val Pro Leu Val Leu Leu Val Thr Leu 
        675                 680                 685             


Ile Thr Thr Leu Val Ile Gly Leu Val Leu Cys Lys Arg Lys Arg Arg 
    690                 695                 700                 


Thr Lys Thr Ile Arg Arg Gln Pro Ile Ile Asn Gly Gly Ile Asn Val 
705                 710                 715                 720 


Glu Ile Gly Asn Pro Ser Tyr Asn Met Tyr Glu Val Asp His Asp His 
                725                 730                 735     


Asn Asp Gly Gly Leu Leu Asp Pro Gly Phe Met Ile Asp Pro Thr Lys 
            740                 745                 750         


Pro Thr Asn Tyr Ser Asn Pro Val Tyr Ala Lys Leu Tyr Met Asp Gly 
        755                 760                 765             


Gln Asn Cys Arg Asn Ser Leu Gly Ser Val Asp Glu Arg Lys Glu Leu 
    770                 775                 780                 


Leu Pro Lys Lys Ile Glu Ile Gly Ile Arg Glu Thr Val Ala 
785                 790                 795             


<210>  8016
<211>  4655
<212>  PRT
<213>  Homo Sapiens

<400>  8016

Met Asp Arg Gly Pro Ala Ala Val Ala Cys Thr Leu Leu Leu Ala Leu 
1               5                   10                  15      


Val Ala Cys Leu Ala Pro Ala Ser Gly Gln Glu Cys Asp Ser Ala His 
            20                  25                  30          


Phe Arg Cys Gly Ser Gly His Cys Ile Pro Ala Asp Trp Arg Cys Asp 
        35                  40                  45              


Gly Thr Lys Asp Cys Ser Asp Asp Ala Asp Glu Ile Gly Cys Ala Val 
    50                  55                  60                  


Val Thr Cys Gln Gln Gly Tyr Phe Lys Cys Gln Ser Glu Gly Gln Cys 
65                  70                  75                  80  


Ile Pro Asn Ser Trp Val Cys Asp Gln Asp Gln Asp Cys Asp Asp Gly 
                85                  90                  95      


Ser Asp Glu Arg Gln Asp Cys Ser Gln Ser Thr Cys Ser Ser His Gln 
            100                 105                 110         


Ile Thr Cys Ser Asn Gly Gln Cys Ile Pro Ser Glu Tyr Arg Cys Asp 
        115                 120                 125             


His Val Arg Asp Cys Pro Asp Gly Ala Asp Glu Asn Asp Cys Gln Tyr 
    130                 135                 140                 


Pro Thr Cys Glu Gln Leu Thr Cys Asp Asn Gly Ala Cys Tyr Asn Thr 
145                 150                 155                 160 


Ser Gln Lys Cys Asp Trp Lys Val Asp Cys Arg Asp Ser Ser Asp Glu 
                165                 170                 175     


Ile Asn Cys Thr Glu Ile Cys Leu His Asn Glu Phe Ser Cys Gly Asn 
            180                 185                 190         


Gly Glu Cys Ile Pro Arg Ala Tyr Val Cys Asp His Asp Asn Asp Cys 
        195                 200                 205             


Gln Asp Gly Ser Asp Glu His Ala Cys Asn Tyr Pro Thr Cys Gly Gly 
    210                 215                 220                 


Tyr Gln Phe Thr Cys Pro Ser Gly Arg Cys Ile Tyr Gln Asn Trp Val 
225                 230                 235                 240 


Cys Asp Gly Glu Asp Asp Cys Lys Asp Asn Gly Asp Glu Asp Gly Cys 
                245                 250                 255     


Glu Ser Gly Pro His Asp Val His Lys Cys Ser Pro Arg Glu Trp Ser 
            260                 265                 270         


Cys Pro Glu Ser Gly Arg Cys Ile Ser Ile Tyr Lys Val Cys Asp Gly 
        275                 280                 285             


Ile Leu Asp Cys Pro Gly Arg Glu Asp Glu Asn Asn Thr Ser Thr Gly 
    290                 295                 300                 


Lys Tyr Cys Ser Met Thr Leu Cys Ser Ala Leu Asn Cys Gln Tyr Gln 
305                 310                 315                 320 


Cys His Glu Thr Pro Tyr Gly Gly Ala Cys Phe Cys Pro Pro Gly Tyr 
                325                 330                 335     


Ile Ile Asn His Asn Asp Ser Arg Thr Cys Val Glu Phe Asp Asp Cys 
            340                 345                 350         


Gln Ile Trp Gly Ile Cys Asp Gln Lys Cys Glu Ser Arg Pro Gly Arg 
        355                 360                 365             


His Leu Cys His Cys Glu Glu Gly Tyr Ile Leu Glu Arg Gly Gln Tyr 
    370                 375                 380                 


Cys Lys Ala Asn Asp Ser Phe Gly Glu Ala Ser Ile Ile Phe Ser Asn 
385                 390                 395                 400 


Gly Arg Asp Leu Leu Ile Gly Asp Ile His Gly Arg Ser Phe Arg Ile 
                405                 410                 415     


Leu Val Glu Ser Gln Asn Arg Gly Val Ala Val Gly Val Ala Phe His 
            420                 425                 430         


Tyr His Leu Gln Arg Val Phe Trp Thr Asp Thr Val Gln Asn Lys Val 
        435                 440                 445             


Phe Ser Val Asp Ile Asn Gly Leu Asn Ile Gln Glu Val Leu Asn Val 
    450                 455                 460                 


Ser Val Glu Thr Pro Glu Asn Leu Ala Val Asp Trp Val Asn Asn Lys 
465                 470                 475                 480 


Ile Tyr Leu Val Glu Thr Lys Val Asn Arg Ile Asp Met Val Asn Leu 
                485                 490                 495     


Asp Gly Ser Tyr Arg Val Thr Leu Ile Thr Glu Asn Leu Gly His Pro 
            500                 505                 510         


Arg Gly Ile Ala Val Asp Pro Thr Val Gly Tyr Leu Phe Phe Ser Asp 
        515                 520                 525             


Trp Glu Ser Leu Ser Gly Glu Pro Lys Leu Glu Arg Ala Phe Met Asp 
    530                 535                 540                 


Gly Ser Asn Arg Lys Asp Leu Val Lys Thr Lys Leu Gly Trp Pro Ala 
545                 550                 555                 560 


Gly Val Thr Leu Asp Met Ile Ser Lys Arg Val Tyr Trp Val Asp Ser 
                565                 570                 575     


Arg Phe Asp Tyr Ile Glu Thr Val Thr Tyr Asp Gly Ile Gln Arg Lys 
            580                 585                 590         


Thr Val Val His Gly Gly Ser Leu Ile Pro His Pro Phe Gly Val Ser 
        595                 600                 605             


Leu Phe Glu Gly Gln Val Phe Phe Thr Asp Trp Thr Lys Met Ala Val 
    610                 615                 620                 


Leu Lys Ala Asn Lys Phe Thr Glu Thr Asn Pro Gln Val Tyr Tyr Gln 
625                 630                 635                 640 


Ala Ser Leu Arg Pro Tyr Gly Val Thr Val Tyr His Ser Leu Arg Gln 
                645                 650                 655     


Pro Tyr Ala Thr Asn Pro Cys Lys Asp Asn Asn Gly Gly Cys Glu Gln 
            660                 665                 670         


Val Cys Val Leu Ser His Arg Thr Asp Asn Asp Gly Leu Gly Phe Arg 
        675                 680                 685             


Cys Lys Cys Thr Phe Gly Phe Gln Leu Asp Thr Asp Glu Arg His Cys 
    690                 695                 700                 


Ile Ala Val Gln Asn Phe Leu Ile Phe Ser Ser Gln Val Ala Ile Arg 
705                 710                 715                 720 


Gly Ile Pro Phe Thr Leu Ser Thr Gln Glu Asp Val Met Val Pro Val 
                725                 730                 735     


Ser Gly Asn Pro Ser Phe Phe Val Gly Ile Asp Phe Asp Ala Gln Asp 
            740                 745                 750         


Ser Thr Ile Phe Phe Ser Asp Met Ser Lys His Met Ile Phe Lys Gln 
        755                 760                 765             


Lys Ile Asp Gly Thr Gly Arg Glu Ile Leu Ala Ala Asn Arg Val Glu 
    770                 775                 780                 


Asn Val Glu Ser Leu Ala Phe Asp Trp Ile Ser Lys Asn Leu Tyr Trp 
785                 790                 795                 800 


Thr Asp Ser His Tyr Lys Ser Ile Ser Val Met Arg Leu Ala Asp Lys 
                805                 810                 815     


Thr Arg Arg Thr Val Val Gln Tyr Leu Asn Asn Pro Arg Ser Val Val 
            820                 825                 830         


Val His Pro Phe Ala Gly Tyr Leu Phe Phe Thr Asp Trp Phe Arg Pro 
        835                 840                 845             


Ala Lys Ile Met Arg Ala Trp Ser Asp Gly Ser His Leu Leu Pro Val 
    850                 855                 860                 


Ile Asn Thr Thr Leu Gly Trp Pro Asn Gly Leu Ala Ile Asp Trp Ala 
865                 870                 875                 880 


Ala Ser Arg Leu Tyr Trp Val Asp Ala Tyr Phe Asp Lys Ile Glu His 
                885                 890                 895     


Ser Thr Phe Asp Gly Leu Asp Arg Arg Arg Leu Gly His Ile Glu Gln 
            900                 905                 910         


Met Thr His Pro Phe Gly Leu Ala Ile Phe Gly Glu His Leu Phe Phe 
        915                 920                 925             


Thr Asp Trp Arg Leu Gly Ala Ile Ile Arg Val Arg Lys Ala Asp Gly 
    930                 935                 940                 


Gly Glu Met Thr Val Ile Arg Ser Gly Ile Ala Tyr Ile Leu His Leu 
945                 950                 955                 960 


Lys Ser Tyr Asp Val Asn Ile Gln Thr Gly Ser Asn Ala Cys Asn Gln 
                965                 970                 975     


Pro Thr His Pro Asn Gly Asp Cys Ser His Phe Cys Phe Pro Val Pro 
            980                 985                 990         


Asn Phe Gln Arg Val Cys Gly Cys  Pro Tyr Gly Met Arg  Leu Ala Ser 
        995                 1000                 1005             


Asn His  Leu Thr Cys Glu Gly  Asp Pro Thr Asn Glu  Pro Pro Thr 
    1010                 1015                 1020             


Glu Gln  Cys Gly Leu Phe Ser  Phe Pro Cys Lys Asn  Gly Arg Cys 
    1025                 1030                 1035             


Val Pro  Asn Tyr Tyr Leu Cys  Asp Gly Val Asp Asp  Cys His Asp 
    1040                 1045                 1050             


Asn Ser  Asp Glu Gln Leu Cys  Gly Thr Leu Asn Asn  Thr Cys Ser 
    1055                 1060                 1065             


Ser Ser  Ala Phe Thr Cys Gly  His Gly Glu Cys Ile  Pro Ala His 
    1070                 1075                 1080             


Trp Arg  Cys Asp Lys Arg Asn  Asp Cys Val Asp Gly  Ser Asp Glu 
    1085                 1090                 1095             


His Asn  Cys Pro Thr His Ala  Pro Ala Ser Cys Leu  Asp Thr Gln 
    1100                 1105                 1110             


Tyr Thr  Cys Asp Asn His Gln  Cys Ile Ser Lys Asn  Trp Val Cys 
    1115                 1120                 1125             


Asp Thr  Asp Asn Asp Cys Gly  Asp Gly Ser Asp Glu  Lys Asn Cys 
    1130                 1135                 1140             


Asn Ser  Thr Glu Thr Cys Gln  Pro Ser Gln Phe Asn  Cys Pro Asn 
    1145                 1150                 1155             


His Arg  Cys Ile Asp Leu Ser  Phe Val Cys Asp Gly  Asp Lys Asp 
    1160                 1165                 1170             


Cys Val  Asp Gly Ser Asp Glu  Val Gly Cys Val Leu  Asn Cys Thr 
    1175                 1180                 1185             


Ala Ser  Gln Phe Lys Cys Ala  Ser Gly Asp Lys Cys  Ile Gly Val 
    1190                 1195                 1200             


Thr Asn  Arg Cys Asp Gly Val  Phe Asp Cys Ser Asp  Asn Ser Asp 
    1205                 1210                 1215             


Glu Ala  Gly Cys Pro Thr Arg  Pro Pro Gly Met Cys  His Ser Asp 
    1220                 1225                 1230             


Glu Phe  Gln Cys Gln Glu Asp  Gly Ile Cys Ile Pro  Asn Phe Trp 
    1235                 1240                 1245             


Glu Cys  Asp Gly His Pro Asp  Cys Leu Tyr Gly Ser  Asp Glu His 
    1250                 1255                 1260             


Asn Ala  Cys Val Pro Lys Thr  Cys Pro Ser Ser Tyr  Phe His Cys 
    1265                 1270                 1275             


Asp Asn  Gly Asn Cys Ile His  Arg Ala Trp Leu Cys  Asp Arg Asp 
    1280                 1285                 1290             


Asn Asp  Cys Gly Asp Met Ser  Asp Glu Lys Asp Cys  Pro Thr Gln 
    1295                 1300                 1305             


Pro Phe  Arg Cys Pro Ser Trp  Gln Trp Gln Cys Leu  Gly His Asn 
    1310                 1315                 1320             


Ile Cys  Val Asn Leu Ser Val  Val Cys Asp Gly Ile  Phe Asp Cys 
    1325                 1330                 1335             


Pro Asn  Gly Thr Asp Glu Ser  Pro Leu Cys Asn Gly  Asn Ser Cys 
    1340                 1345                 1350             


Ser Asp  Phe Asn Gly Gly Cys  Thr His Glu Cys Val  Gln Glu Pro 
    1355                 1360                 1365             


Phe Gly  Ala Lys Cys Leu Cys  Pro Leu Gly Phe Leu  Leu Ala Asn 
    1370                 1375                 1380             


Asp Ser  Lys Thr Cys Glu Asp  Ile Asp Glu Cys Asp  Ile Leu Gly 
    1385                 1390                 1395             


Ser Cys  Ser Gln His Cys Tyr  Asn Met Arg Gly Ser  Phe Arg Cys 
    1400                 1405                 1410             


Ser Cys  Asp Thr Gly Tyr Met  Leu Glu Ser Asp Gly  Arg Thr Cys 
    1415                 1420                 1425             


Lys Val  Thr Ala Ser Glu Ser  Leu Leu Leu Leu Val  Ala Ser Gln 
    1430                 1435                 1440             


Asn Lys  Ile Ile Ala Asp Ser  Val Thr Ser Gln Val  His Asn Ile 
    1445                 1450                 1455             


Tyr Ser  Leu Val Glu Asn Gly  Ser Tyr Ile Val Ala  Val Asp Phe 
    1460                 1465                 1470             


Asp Ser  Ile Ser Gly Arg Ile  Phe Trp Ser Asp Ala  Thr Gln Gly 
    1475                 1480                 1485             


Lys Thr  Trp Ser Ala Phe Gln  Asn Gly Thr Asp Arg  Arg Val Val 
    1490                 1495                 1500             


Phe Asp  Ser Ser Ile Ile Leu  Thr Glu Thr Ile Ala  Ile Asp Trp 
    1505                 1510                 1515             


Val Gly  Arg Asn Leu Tyr Trp  Thr Asp Tyr Ala Leu  Glu Thr Ile 
    1520                 1525                 1530             


Glu Val  Ser Lys Ile Asp Gly  Ser His Arg Thr Val  Leu Ile Ser 
    1535                 1540                 1545             


Lys Asn  Leu Thr Asn Pro Arg  Gly Leu Ala Leu Asp  Pro Arg Met 
    1550                 1555                 1560             


Asn Glu  His Leu Leu Phe Trp  Ser Asp Trp Gly His  His Pro Arg 
    1565                 1570                 1575             


Ile Glu  Arg Ala Ser Met Asp  Gly Ser Met Arg Thr  Val Ile Val 
    1580                 1585                 1590             


Gln Asp  Lys Ile Phe Trp Pro  Cys Gly Leu Thr Ile  Asp Tyr Pro 
    1595                 1600                 1605             


Asn Arg  Leu Leu Tyr Phe Met  Asp Ser Tyr Leu Asp  Tyr Met Asp 
    1610                 1615                 1620             


Phe Cys  Asp Tyr Asn Gly His  His Arg Arg Gln Val  Ile Ala Ser 
    1625                 1630                 1635             


Asp Leu  Ile Ile Arg His Pro  Tyr Ala Leu Thr Leu  Phe Glu Asp 
    1640                 1645                 1650             


Ser Val  Tyr Trp Thr Asp Arg  Ala Thr Arg Arg Val  Met Arg Ala 
    1655                 1660                 1665             


Asn Lys  Trp His Gly Gly Asn  Gln Ser Val Val Met  Tyr Asn Ile 
    1670                 1675                 1680             


Gln Trp  Pro Leu Gly Ile Val  Ala Val His Pro Ser  Lys Gln Pro 
    1685                 1690                 1695             


Asn Ser  Val Asn Pro Cys Ala  Phe Ser Arg Cys Ser  His Leu Cys 
    1700                 1705                 1710             


Leu Leu  Ser Ser Gln Gly Pro  His Phe Tyr Ser Cys  Val Cys Pro 
    1715                 1720                 1725             


Ser Gly  Trp Ser Leu Ser Pro  Asp Leu Leu Asn Cys  Leu Arg Asp 
    1730                 1735                 1740             


Asp Gln  Pro Phe Leu Ile Thr  Val Arg Gln His Ile  Ile Phe Gly 
    1745                 1750                 1755             


Ile Ser  Leu Asn Pro Glu Val  Lys Ser Asn Asp Ala  Met Val Pro 
    1760                 1765                 1770             


Ile Ala  Gly Ile Gln Asn Gly  Leu Asp Val Glu Phe  Asp Asp Ala 
    1775                 1780                 1785             


Glu Gln  Tyr Ile Tyr Trp Val  Glu Asn Pro Gly Glu  Ile His Arg 
    1790                 1795                 1800             


Val Lys  Thr Asp Gly Thr Asn  Arg Thr Val Phe Ala  Ser Ile Ser 
    1805                 1810                 1815             


Met Val  Gly Pro Ser Met Asn  Leu Ala Leu Asp Trp  Ile Ser Arg 
    1820                 1825                 1830             


Asn Leu  Tyr Ser Thr Asn Pro  Arg Thr Gln Ser Ile  Glu Val Leu 
    1835                 1840                 1845             


Thr Leu  His Gly Asp Ile Arg  Tyr Arg Lys Thr Leu  Ile Ala Asn 
    1850                 1855                 1860             


Asp Gly  Thr Ala Leu Gly Val  Gly Phe Pro Ile Gly  Ile Thr Val 
    1865                 1870                 1875             


Asp Pro  Ala Arg Gly Lys Leu  Tyr Trp Ser Asp Gln  Gly Thr Asp 
    1880                 1885                 1890             


Ser Gly  Val Pro Ala Lys Ile  Ala Ser Ala Asn Met  Asp Gly Thr 
    1895                 1900                 1905             


Ser Val  Lys Thr Leu Phe Thr  Gly Asn Leu Glu His  Leu Glu Cys 
    1910                 1915                 1920             


Val Thr  Leu Asp Ile Glu Glu  Gln Lys Leu Tyr Trp  Ala Val Thr 
    1925                 1930                 1935             


Gly Arg  Gly Val Ile Glu Arg  Gly Asn Val Asp Gly  Thr Asp Arg 
    1940                 1945                 1950             


Met Ile  Leu Val His Gln Leu  Ser His Pro Trp Gly  Ile Ala Val 
    1955                 1960                 1965             


His Asp  Ser Phe Leu Tyr Tyr  Thr Asp Glu Gln Tyr  Glu Val Ile 
    1970                 1975                 1980             


Glu Arg  Val Asp Lys Ala Thr  Gly Ala Asn Lys Ile  Val Leu Arg 
    1985                 1990                 1995             


Asp Asn  Val Pro Asn Leu Arg  Gly Leu Gln Val Tyr  His Arg Arg 
    2000                 2005                 2010             


Asn Ala  Ala Glu Ser Ser Asn  Gly Cys Ser Asn Asn  Met Asn Ala 
    2015                 2020                 2025             


Cys Gln  Gln Ile Cys Leu Pro  Val Pro Gly Gly Leu  Phe Ser Cys 
    2030                 2035                 2040             


Ala Cys  Ala Thr Gly Phe Lys  Leu Asn Pro Asp Asn  Arg Ser Cys 
    2045                 2050                 2055             


Ser Pro  Tyr Asn Ser Phe Ile  Val Val Ser Met Leu  Ser Ala Ile 
    2060                 2065                 2070             


Arg Gly  Phe Ser Leu Glu Leu  Ser Asp His Ser Glu  Thr Met Val 
    2075                 2080                 2085             


Pro Val  Ala Gly Gln Gly Arg  Asn Ala Leu His Val  Asp Val Asp 
    2090                 2095                 2100             


Val Ser  Ser Gly Phe Ile Tyr  Trp Cys Asp Phe Ser  Ser Ser Val 
    2105                 2110                 2115             


Ala Ser  Asp Asn Ala Ile Arg  Arg Ile Lys Pro Asp  Gly Ser Ser 
    2120                 2125                 2130             


Leu Met  Asn Ile Val Thr His  Gly Ile Gly Glu Asn  Gly Val Arg 
    2135                 2140                 2145             


Gly Ile  Ala Val Asp Trp Val  Ala Gly Asn Leu Tyr  Phe Thr Asn 
    2150                 2155                 2160             


Ala Phe  Val Ser Glu Thr Leu  Ile Glu Val Leu Arg  Ile Asn Thr 
    2165                 2170                 2175             


Thr Tyr  Arg Arg Val Leu Leu  Lys Val Thr Val Asp  Met Pro Arg 
    2180                 2185                 2190             


His Ile  Val Val Asp Pro Lys  Asn Arg Tyr Leu Phe  Trp Ala Asp 
    2195                 2200                 2205             


Tyr Gly  Gln Arg Pro Lys Ile  Glu Arg Ser Phe Leu  Asp Cys Thr 
    2210                 2215                 2220             


Asn Arg  Thr Val Leu Val Ser  Glu Gly Ile Val Thr  Pro Arg Gly 
    2225                 2230                 2235             


Leu Ala  Val Asp Arg Ser Asp  Gly Tyr Val Tyr Trp  Val Asp Asp 
    2240                 2245                 2250             


Ser Leu  Asp Ile Ile Ala Arg  Ile Arg Ile Asn Gly  Glu Asn Ser 
    2255                 2260                 2265             


Glu Val  Ile Arg Tyr Gly Ser  Arg Tyr Pro Thr Pro  Tyr Gly Ile 
    2270                 2275                 2280             


Thr Val  Phe Glu Asn Ser Ile  Ile Trp Val Asp Arg  Asn Leu Lys 
    2285                 2290                 2295             


Lys Ile  Phe Gln Ala Ser Lys  Glu Pro Glu Asn Thr  Glu Pro Pro 
    2300                 2305                 2310             


Thr Val  Ile Arg Asp Asn Ile  Asn Trp Leu Arg Asp  Val Thr Ile 
    2315                 2320                 2325             


Phe Asp  Lys Gln Val Gln Pro  Arg Ser Pro Ala Glu  Val Asn Asn 
    2330                 2335                 2340             


Asn Pro  Cys Leu Glu Asn Asn  Gly Gly Cys Ser His  Leu Cys Phe 
    2345                 2350                 2355             


Ala Leu  Pro Gly Leu His Thr  Pro Lys Cys Asp Cys  Ala Phe Gly 
    2360                 2365                 2370             


Thr Leu  Gln Ser Asp Gly Lys  Asn Cys Ala Ile Ser  Thr Glu Asn 
    2375                 2380                 2385             


Phe Leu  Ile Phe Ala Leu Ser  Asn Ser Leu Arg Ser  Leu His Leu 
    2390                 2395                 2400             


Asp Pro  Glu Asn His Ser Pro  Pro Phe Gln Thr Ile  Asn Val Glu 
    2405                 2410                 2415             


Arg Thr  Val Met Ser Leu Asp  Tyr Asp Ser Val Ser  Asp Arg Ile 
    2420                 2425                 2430             


Tyr Phe  Thr Gln Asn Leu Ala  Ser Gly Val Gly Gln  Ile Ser Tyr 
    2435                 2440                 2445             


Ala Thr  Leu Ser Ser Gly Ile  His Thr Pro Thr Val  Ile Ala Ser 
    2450                 2455                 2460             


Gly Ile  Gly Thr Ala Asp Gly  Ile Ala Phe Asp Trp  Ile Thr Arg 
    2465                 2470                 2475             


Arg Ile  Tyr Tyr Ser Asp Tyr  Leu Asn Gln Met Ile  Asn Ser Met 
    2480                 2485                 2490             


Ala Glu  Asp Gly Ser Asn Arg  Thr Val Ile Ala Arg  Val Pro Lys 
    2495                 2500                 2505             


Pro Arg  Ala Ile Val Leu Asp  Pro Cys Gln Gly Tyr  Leu Tyr Trp 
    2510                 2515                 2520             


Ala Asp  Trp Asp Thr His Ala  Lys Ile Glu Arg Ala  Thr Leu Gly 
    2525                 2530                 2535             


Gly Asn  Phe Arg Val Pro Ile  Val Asn Ser Ser Leu  Val Met Pro 
    2540                 2545                 2550             


Ser Gly  Leu Thr Leu Asp Tyr  Glu Glu Asp Leu Leu  Tyr Trp Val 
    2555                 2560                 2565             


Asp Ala  Ser Leu Gln Arg Ile  Glu Arg Ser Thr Leu  Thr Gly Val 
    2570                 2575                 2580             


Asp Arg  Glu Val Ile Val Asn  Ala Ala Val His Ala  Phe Gly Leu 
    2585                 2590                 2595             


Thr Leu  Tyr Gly Gln Tyr Ile  Tyr Trp Thr Asp Leu  Tyr Thr Gln 
    2600                 2605                 2610             


Arg Ile  Tyr Arg Ala Asn Lys  Tyr Asp Gly Ser Gly  Gln Ile Ala 
    2615                 2620                 2625             


Met Thr  Thr Asn Leu Leu Ser  Gln Pro Arg Gly Ile  Asn Thr Val 
    2630                 2635                 2640             


Val Lys  Asn Gln Lys Gln Gln  Cys Asn Asn Pro Cys  Glu Gln Phe 
    2645                 2650                 2655             


Asn Gly  Gly Cys Ser His Ile  Cys Ala Pro Gly Pro  Asn Gly Ala 
    2660                 2665                 2670             


Glu Cys  Gln Cys Pro His Glu  Gly Asn Trp Tyr Leu  Ala Asn Asn 
    2675                 2680                 2685             


Arg Lys  His Cys Ile Val Asp  Asn Gly Glu Arg Cys  Gly Ala Ser 
    2690                 2695                 2700             


Ser Phe  Thr Cys Ser Asn Gly  Arg Cys Ile Ser Glu  Glu Trp Lys 
    2705                 2710                 2715             


Cys Asp  Asn Asp Asn Asp Cys  Gly Asp Gly Ser Asp  Glu Met Glu 
    2720                 2725                 2730             


Ser Val  Cys Ala Leu His Thr  Cys Ser Pro Thr Ala  Phe Thr Cys 
    2735                 2740                 2745             


Ala Asn  Gly Arg Cys Val Gln  Tyr Ser Tyr Arg Cys  Asp Tyr Tyr 
    2750                 2755                 2760             


Asn Asp  Cys Gly Asp Gly Ser  Asp Glu Ala Gly Cys  Leu Phe Arg 
    2765                 2770                 2775             


Asp Cys  Asn Ala Thr Thr Glu  Phe Met Cys Asn Asn  Arg Arg Cys 
    2780                 2785                 2790             


Ile Pro  Arg Glu Phe Ile Cys  Asn Gly Val Asp Asn  Cys His Asp 
    2795                 2800                 2805             


Asn Asn  Thr Ser Asp Glu Lys  Asn Cys Pro Asp Arg  Thr Cys Gln 
    2810                 2815                 2820             


Ser Gly  Tyr Thr Lys Cys His  Asn Ser Asn Ile Cys  Ile Pro Arg 
    2825                 2830                 2835             


Val Tyr  Leu Cys Asp Gly Asp  Asn Asp Cys Gly Asp  Asn Ser Asp 
    2840                 2845                 2850             


Glu Asn  Pro Thr Tyr Cys Thr  Thr His Thr Cys Ser  Ser Ser Glu 
    2855                 2860                 2865             


Phe Gln  Cys Ala Ser Gly Arg  Cys Ile Pro Gln His  Trp Tyr Cys 
    2870                 2875                 2880             


Asp Gln  Glu Thr Asp Cys Phe  Asp Ala Ser Asp Glu  Pro Ala Ser 
    2885                 2890                 2895             


Cys Gly  His Ser Glu Arg Thr  Cys Leu Ala Asp Glu  Phe Lys Cys 
    2900                 2905                 2910             


Asp Gly  Gly Arg Cys Ile Pro  Ser Glu Trp Ile Cys  Asp Gly Asp 
    2915                 2920                 2925             


Asn Asp  Cys Gly Asp Met Ser  Asp Glu Asp Lys Arg  His Gln Cys 
    2930                 2935                 2940             


Gln Asn  Gln Asn Cys Ser Asp  Ser Glu Phe Leu Cys  Val Asn Asp 
    2945                 2950                 2955             


Arg Pro  Pro Asp Arg Arg Cys  Ile Pro Gln Ser Trp  Val Cys Asp 
    2960                 2965                 2970             


Gly Asp  Val Asp Cys Thr Asp  Gly Tyr Asp Glu Asn  Gln Asn Cys 
    2975                 2980                 2985             


Thr Arg  Arg Thr Cys Ser Glu  Asn Glu Phe Thr Cys  Gly Tyr Gly 
    2990                 2995                 3000             


Leu Cys  Ile Pro Lys Ile Phe  Arg Cys Asp Arg His  Asn Asp Cys 
    3005                 3010                 3015             


Gly Asp  Tyr Ser Asp Glu Arg  Gly Cys Leu Tyr Gln  Thr Cys Gln 
    3020                 3025                 3030             


Gln Asn  Gln Phe Thr Cys Gln  Asn Gly Arg Cys Ile  Ser Lys Thr 
    3035                 3040                 3045             


Phe Val  Cys Asp Glu Asp Asn  Asp Cys Gly Asp Gly  Ser Asp Glu 
    3050                 3055                 3060             


Leu Met  His Leu Cys His Thr  Pro Glu Pro Thr Cys  Pro Pro His 
    3065                 3070                 3075             


Glu Phe  Lys Cys Asp Asn Gly  Arg Cys Ile Glu Met  Met Lys Leu 
    3080                 3085                 3090             


Cys Asn  His Leu Asp Asp Cys  Leu Asp Asn Ser Asp  Glu Lys Gly 
    3095                 3100                 3105             


Cys Gly  Ile Asn Glu Cys His  Asp Pro Ser Ile Ser  Gly Cys Asp 
    3110                 3115                 3120             


His Asn  Cys Thr Asp Thr Leu  Thr Ser Phe Tyr Cys  Ser Cys Arg 
    3125                 3130                 3135             


Pro Gly  Tyr Lys Leu Met Ser  Asp Lys Arg Thr Cys  Val Asp Ile 
    3140                 3145                 3150             


Asp Glu  Cys Thr Glu Met Pro  Phe Val Cys Ser Gln  Lys Cys Glu 
    3155                 3160                 3165             


Asn Val  Ile Gly Ser Tyr Ile  Cys Lys Cys Ala Pro  Gly Tyr Leu 
    3170                 3175                 3180             


Arg Glu  Pro Asp Gly Lys Thr  Cys Arg Gln Asn Ser  Asn Ile Glu 
    3185                 3190                 3195             


Pro Tyr  Leu Ile Phe Ser Asn  Arg Tyr Tyr Leu Arg  Asn Leu Thr 
    3200                 3205                 3210             


Ile Asp  Gly Tyr Phe Tyr Ser  Leu Ile Leu Glu Gly  Leu Asp Asn 
    3215                 3220                 3225             


Val Val  Ala Leu Asp Phe Asp  Arg Val Glu Lys Arg  Leu Tyr Trp 
    3230                 3235                 3240             


Ile Asp  Thr Gln Arg Gln Val  Ile Glu Arg Met Phe  Leu Asn Lys 
    3245                 3250                 3255             


Thr Asn  Lys Glu Thr Ile Ile  Asn His Arg Leu Pro  Ala Ala Glu 
    3260                 3265                 3270             


Ser Leu  Ala Val Asp Trp Val  Ser Arg Lys Leu Tyr  Trp Leu Asp 
    3275                 3280                 3285             


Ala Arg  Leu Asp Gly Leu Phe  Val Ser Asp Leu Asn  Gly Gly His 
    3290                 3295                 3300             


Arg Arg  Met Leu Ala Gln His  Cys Val Asp Ala Asn  Asn Thr Phe 
    3305                 3310                 3315             


Cys Phe  Asp Asn Pro Arg Gly  Leu Ala Leu His Pro  Gln Tyr Gly 
    3320                 3325                 3330             


Tyr Leu  Tyr Trp Ala Asp Trp  Gly His Arg Ala Tyr  Ile Gly Arg 
    3335                 3340                 3345             


Val Gly  Met Asp Gly Thr Asn  Lys Ser Val Ile Ile  Ser Thr Lys 
    3350                 3355                 3360             


Leu Glu  Trp Pro Asn Gly Ile  Thr Ile Asp Tyr Thr  Asn Asp Leu 
    3365                 3370                 3375             


Leu Tyr  Trp Ala Asp Ala His  Leu Gly Tyr Ile Glu  Tyr Ser Asp 
    3380                 3385                 3390             


Leu Glu  Gly His His Arg His  Thr Val Tyr Asp Gly  Ala Leu Pro 
    3395                 3400                 3405             


His Pro  Phe Ala Ile Thr Ile  Phe Glu Asp Thr Ile  Tyr Trp Thr 
    3410                 3415                 3420             


Asp Trp  Asn Thr Arg Thr Val  Glu Lys Gly Asn Lys  Tyr Asp Gly 
    3425                 3430                 3435             


Ser Asn  Arg Gln Thr Leu Val  Asn Thr Thr His Arg  Pro Phe Asp 
    3440                 3445                 3450             


Ile His  Val Tyr His Pro Tyr  Arg Gln Pro Ile Val  Ser Asn Pro 
    3455                 3460                 3465             


Cys Gly  Thr Asn Asn Gly Gly  Cys Ser His Leu Cys  Leu Ile Lys 
    3470                 3475                 3480             


Pro Gly  Gly Lys Gly Phe Thr  Cys Glu Cys Pro Asp  Asp Phe Arg 
    3485                 3490                 3495             


Thr Leu  Gln Leu Ser Gly Ser  Thr Tyr Cys Met Pro  Met Cys Ser 
    3500                 3505                 3510             


Ser Thr  Gln Phe Leu Cys Ala  Asn Asn Glu Lys Cys  Ile Pro Ile 
    3515                 3520                 3525             


Trp Trp  Lys Cys Asp Gly Gln  Lys Asp Cys Ser Asp  Gly Ser Asp 
    3530                 3535                 3540             


Glu Leu  Ala Leu Cys Pro Gln  Arg Phe Cys Arg Leu  Gly Gln Phe 
    3545                 3550                 3555             


Gln Cys  Ser Asp Gly Asn Cys  Thr Ser Pro Gln Thr  Leu Cys Asn 
    3560                 3565                 3570             


Ala His  Gln Asn Cys Pro Asp  Gly Ser Asp Glu Asp  Arg Leu Leu 
    3575                 3580                 3585             


Cys Glu  Asn His His Cys Asp  Ser Asn Glu Trp Gln  Cys Ala Asn 
    3590                 3595                 3600             


Lys Arg  Cys Ile Pro Glu Ser  Trp Gln Cys Asp Thr  Phe Asn Asp 
    3605                 3610                 3615             


Cys Glu  Asp Asn Ser Asp Glu  Asp Ser Ser His Cys  Ala Ser Arg 
    3620                 3625                 3630             


Thr Cys  Arg Pro Gly Gln Phe  Arg Cys Ala Asn Gly  Arg Cys Ile 
    3635                 3640                 3645             


Pro Gln  Ala Trp Lys Cys Asp  Val Asp Asn Asp Cys  Gly Asp His 
    3650                 3655                 3660             


Ser Asp  Glu Pro Ile Glu Glu  Cys Met Ser Ser Ala  His Leu Cys 
    3665                 3670                 3675             


Asp Asn  Phe Thr Glu Phe Ser  Cys Lys Thr Asn Tyr  Arg Cys Ile 
    3680                 3685                 3690             


Pro Lys  Trp Ala Val Cys Asn  Gly Val Asp Asp Cys  Arg Asp Asn 
    3695                 3700                 3705             


Ser Asp  Glu Gln Gly Cys Glu  Glu Arg Thr Cys His  Pro Val Gly 
    3710                 3715                 3720             


Asp Phe  Arg Cys Lys Asn His  His Cys Ile Pro Leu  Arg Trp Gln 
    3725                 3730                 3735             


Cys Asp  Gly Gln Asn Asp Cys  Gly Asp Asn Ser Asp  Glu Glu Asn 
    3740                 3745                 3750             


Cys Ala  Pro Arg Glu Cys Thr  Glu Ser Glu Phe Arg  Cys Val Asn 
    3755                 3760                 3765             


Gln Gln  Cys Ile Pro Ser Arg  Trp Ile Cys Asp His  Tyr Asn Asp 
    3770                 3775                 3780             


Cys Gly  Asp Asn Ser Asp Glu  Arg Asp Cys Glu Met  Arg Thr Cys 
    3785                 3790                 3795             


His Pro  Glu Tyr Phe Gln Cys  Thr Ser Gly His Cys  Val His Ser 
    3800                 3805                 3810             


Glu Leu  Lys Cys Asp Gly Ser  Ala Asp Cys Leu Asp  Ala Ser Asp 
    3815                 3820                 3825             


Glu Ala  Asp Cys Pro Thr Arg  Phe Pro Asp Gly Ala  Tyr Cys Gln 
    3830                 3835                 3840             


Ala Thr  Met Phe Glu Cys Lys  Asn His Val Cys Ile  Pro Pro Tyr 
    3845                 3850                 3855             


Trp Lys  Cys Asp Gly Asp Asp  Asp Cys Gly Asp Gly  Ser Asp Glu 
    3860                 3865                 3870             


Glu Leu  His Leu Cys Leu Asp  Val Pro Cys Asn Ser  Pro Asn Arg 
    3875                 3880                 3885             


Phe Arg  Cys Asp Asn Asn Arg  Cys Ile Tyr Ser His  Glu Val Cys 
    3890                 3895                 3900             


Asn Gly  Val Asp Asp Cys Gly  Asp Gly Thr Asp Glu  Thr Glu Glu 
    3905                 3910                 3915             


His Cys  Arg Lys Pro Thr Pro  Lys Pro Cys Thr Glu  Tyr Glu Tyr 
    3920                 3925                 3930             


Lys Cys  Gly Asn Gly His Cys  Ile Pro His Asp Asn  Val Cys Asp 
    3935                 3940                 3945             


Asp Ala  Asp Asp Cys Gly Asp  Trp Ser Asp Glu Leu  Gly Cys Asn 
    3950                 3955                 3960             


Lys Gly  Lys Glu Arg Thr Cys  Ala Glu Asn Ile Cys  Glu Gln Asn 
    3965                 3970                 3975             


Cys Thr  Gln Leu Asn Glu Gly  Gly Phe Ile Cys Ser  Cys Thr Ala 
    3980                 3985                 3990             


Gly Phe  Glu Thr Asn Val Phe  Asp Arg Thr Ser Cys  Leu Asp Ile 
    3995                 4000                 4005             


Asn Glu  Cys Glu Gln Phe Gly  Thr Cys Pro Gln His  Cys Arg Asn 
    4010                 4015                 4020             


Thr Lys  Gly Ser Tyr Glu Cys  Val Cys Ala Asp Gly  Phe Thr Ser 
    4025                 4030                 4035             


Met Ser  Asp Arg Pro Gly Lys  Arg Cys Ala Ala Glu  Gly Ser Ser 
    4040                 4045                 4050             


Pro Leu  Leu Leu Leu Pro Asp  Asn Val Arg Ile Arg  Lys Tyr Asn 
    4055                 4060                 4065             


Leu Ser  Ser Glu Arg Phe Ser  Glu Tyr Leu Gln Asp  Glu Glu Tyr 
    4070                 4075                 4080             


Ile Gln  Ala Val Asp Tyr Asp  Trp Asp Pro Lys Asp  Ile Gly Leu 
    4085                 4090                 4095             


Ser Val  Val Tyr Tyr Thr Val  Arg Gly Glu Gly Ser  Arg Phe Gly 
    4100                 4105                 4110             


Ala Ile  Lys Arg Ala Tyr Ile  Pro Asn Phe Glu Ser  Gly Arg Asn 
    4115                 4120                 4125             


Asn Leu  Val Gln Glu Val Asp  Leu Lys Leu Lys Tyr  Val Met Gln 
    4130                 4135                 4140             


Pro Asp  Gly Ile Ala Val Asp  Trp Val Gly Arg His  Ile Tyr Trp 
    4145                 4150                 4155             


Ser Asp  Val Lys Asn Lys Arg  Ile Glu Val Ala Lys  Leu Asp Gly 
    4160                 4165                 4170             


Arg Tyr  Arg Lys Trp Leu Ile  Ser Thr Asp Leu Asp  Gln Pro Ala 
    4175                 4180                 4185             


Ala Ile  Ala Val Asn Pro Lys  Leu Gly Leu Met Phe  Trp Thr Asp 
    4190                 4195                 4200             


Trp Gly  Lys Glu Pro Lys Ile  Glu Ser Ala Trp Met  Asn Gly Glu 
    4205                 4210                 4215             


Asp Arg  Asn Ile Leu Val Phe  Glu Asp Leu Gly Trp  Pro Thr Gly 
    4220                 4225                 4230             


Leu Ser  Ile Asp Tyr Leu Asn  Asn Asp Arg Ile Tyr  Trp Ser Asp 
    4235                 4240                 4245             


Phe Lys  Glu Asp Val Ile Glu  Thr Ile Lys Tyr Asp  Gly Thr Asp 
    4250                 4255                 4260             


Arg Arg  Val Ile Ala Lys Glu  Ala Met Asn Pro Tyr  Ser Leu Asp 
    4265                 4270                 4275             


Ile Phe  Glu Asp Gln Leu Tyr  Trp Ile Ser Lys Glu  Lys Gly Glu 
    4280                 4285                 4290             


Val Trp  Lys Gln Asn Lys Phe  Gly Gln Gly Lys Lys  Glu Lys Thr 
    4295                 4300                 4305             


Leu Val  Val Asn Pro Trp Leu  Thr Gln Val Arg Ile  Phe His Gln 
    4310                 4315                 4320             


Leu Arg  Tyr Asn Lys Ser Val  Pro Asn Leu Cys Lys  Gln Ile Cys 
    4325                 4330                 4335             


Ser His  Leu Cys Leu Leu Arg  Pro Gly Gly Tyr Ser  Cys Ala Cys 
    4340                 4345                 4350             


Pro Gln  Gly Ser Ser Phe Ile  Glu Gly Ser Thr Thr  Glu Cys Asp 
    4355                 4360                 4365             


Ala Ala  Ile Glu Leu Pro Ile  Asn Leu Pro Pro Pro  Cys Arg Cys 
    4370                 4375                 4380             


Met His  Gly Gly Asn Cys Tyr  Phe Asp Glu Thr Asp  Leu Pro Lys 
    4385                 4390                 4395             


Cys Lys  Cys Pro Ser Gly Tyr  Thr Gly Lys Tyr Cys  Glu Met Ala 
    4400                 4405                 4410             


Phe Ser  Lys Gly Ile Ser Pro  Gly Thr Thr Ala Val  Ala Val Leu 
    4415                 4420                 4425             


Leu Thr  Ile Leu Leu Ile Val  Val Ile Gly Ala Leu  Ala Ile Ala 
    4430                 4435                 4440             


Gly Phe  Phe His Tyr Arg Arg  Thr Gly Ser Leu Leu  Pro Ala Leu 
    4445                 4450                 4455             


Pro Lys  Leu Pro Ser Leu Ser  Ser Leu Val Lys Pro  Ser Glu Asn 
    4460                 4465                 4470             


Gly Asn  Gly Val Thr Phe Arg  Ser Gly Ala Asp Leu  Asn Met Asp 
    4475                 4480                 4485             


Ile Gly  Val Ser Gly Phe Gly  Pro Glu Thr Ala Ile  Asp Arg Ser 
    4490                 4495                 4500             


Met Ala  Met Ser Glu Asp Phe  Val Met Glu Met Gly  Lys Gln Pro 
    4505                 4510                 4515             


Ile Ile  Phe Glu Asn Pro Met  Tyr Ser Ala Arg Asp  Ser Ala Val 
    4520                 4525                 4530             


Lys Val  Val Gln Pro Ile Gln  Val Thr Val Ser Glu  Asn Val Asp 
    4535                 4540                 4545             


Asn Lys  Asn Tyr Gly Ser Pro  Ile Asn Pro Ser Glu  Ile Val Pro 
    4550                 4555                 4560             


Glu Thr  Asn Pro Thr Ser Pro  Ala Ala Asp Gly Thr  Gln Val Thr 
    4565                 4570                 4575             


Lys Trp  Asn Leu Phe Lys Arg  Lys Ser Lys Gln Thr  Thr Asn Phe 
    4580                 4585                 4590             


Glu Asn  Pro Ile Tyr Ala Gln  Met Glu Asn Glu Gln  Lys Glu Ser 
    4595                 4600                 4605             


Val Ala  Ala Thr Pro Pro Pro  Ser Pro Ser Leu Pro  Ala Lys Pro 
    4610                 4615                 4620             


Lys Pro  Pro Ser Arg Arg Asp  Pro Thr Pro Thr Tyr  Ser Ala Thr 
    4625                 4630                 4635             


Glu Asp  Thr Phe Lys Asp Thr  Ala Asn Leu Val Lys  Glu Asp Ser 
    4640                 4645                 4650             


Glu Val  
    4655 


<210>  8017
<211>  1225
<212>  PRT
<213>  Homo Sapiens

<400>  8017

Met Asp Arg Gly Pro Ala Ala Val Ala Cys Thr Leu Leu Leu Ala Leu 
1               5                   10                  15      


Val Ala Cys Leu Ala Pro Ala Ser Gly Gln Glu Cys Asp Ser Ala His 
            20                  25                  30          


Phe Arg Cys Gly Ser Gly His Cys Ile Pro Ala Asp Trp Arg Cys Asp 
        35                  40                  45              


Gly Thr Lys Asp Cys Ser Asp Asp Ala Asp Glu Ile Gly Cys Ala Val 
    50                  55                  60                  


Val Thr Cys Gln Gln Gly Tyr Phe Lys Cys Gln Ser Glu Gly Gln Cys 
65                  70                  75                  80  


Ile Pro Asn Ser Trp Val Cys Asp Gln Asp Gln Asp Cys Asp Asp Gly 
                85                  90                  95      


Ser Asp Glu Arg Gln Asp Cys Ser Gln Ser Thr Cys Ser Ser His Gln 
            100                 105                 110         


Ile Thr Cys Ser Asn Gly Gln Cys Ile Pro Ser Glu Tyr Arg Cys Asp 
        115                 120                 125             


His Val Arg Asp Cys Pro Asp Gly Ala Asp Glu Asn Asp Cys Gln Tyr 
    130                 135                 140                 


Pro Thr Cys Glu Gln Leu Thr Cys Asp Asn Gly Ala Cys Tyr Asn Thr 
145                 150                 155                 160 


Ser Gln Lys Cys Asp Trp Lys Val Asp Cys Arg Asp Ser Ser Asp Glu 
                165                 170                 175     


Ile Asn Cys Thr Glu Ile Cys Leu His Asn Glu Phe Ser Cys Gly Asn 
            180                 185                 190         


Gly Glu Cys Ile Pro Arg Ala Tyr Val Cys Asp His Asp Asn Asp Cys 
        195                 200                 205             


Gln Asp Gly Ser Asp Glu His Ala Cys Asn Tyr Pro Thr Cys Gly Gly 
    210                 215                 220                 


Tyr Gln Phe Thr Cys Pro Ser Gly Arg Cys Ile Tyr Gln Asn Trp Val 
225                 230                 235                 240 


Cys Asp Gly Glu Asp Asp Cys Lys Asp Asn Gly Asp Glu Asp Gly Cys 
                245                 250                 255     


Glu Ser Gly Pro His Asp Val His Lys Cys Ser Pro Arg Glu Trp Ser 
            260                 265                 270         


Cys Pro Glu Ser Gly Arg Cys Ile Ser Ile Tyr Lys Val Cys Asp Gly 
        275                 280                 285             


Ile Leu Asp Cys Pro Gly Arg Glu Asp Glu Asn Asn Thr Ser Thr Gly 
    290                 295                 300                 


Lys Tyr Cys Ser Met Thr Leu Cys Ser Ala Leu Asn Cys Gln Tyr Gln 
305                 310                 315                 320 


Cys His Glu Thr Pro Tyr Gly Gly Ala Cys Phe Cys Pro Pro Gly Tyr 
                325                 330                 335     


Ile Ile Asn His Asn Asp Ser Arg Thr Cys Val Glu Phe Asp Asp Cys 
            340                 345                 350         


Gln Ile Trp Gly Ile Cys Asp Gln Lys Cys Glu Ser Arg Pro Gly Arg 
        355                 360                 365             


His Leu Cys His Cys Glu Glu Gly Tyr Ile Leu Glu Arg Gly Gln Tyr 
    370                 375                 380                 


Cys Lys Ala Asn Asp Ser Phe Gly Glu Ala Ser Ile Ile Phe Ser Asn 
385                 390                 395                 400 


Gly Arg Asp Leu Leu Ile Gly Asp Ile His Gly Arg Ser Phe Arg Ile 
                405                 410                 415     


Leu Val Glu Ser Gln Asn Arg Gly Val Ala Val Gly Val Ala Phe His 
            420                 425                 430         


Tyr His Leu Gln Arg Val Phe Trp Thr Asp Thr Val Gln Asn Lys Val 
        435                 440                 445             


Phe Ser Val Asp Ile Asn Gly Leu Asn Ile Gln Glu Val Leu Asn Val 
    450                 455                 460                 


Ser Val Glu Thr Pro Glu Asn Leu Ala Val Asp Trp Val Asn Asn Lys 
465                 470                 475                 480 


Ile Tyr Leu Val Glu Thr Lys Val Asn Arg Ile Asp Met Val Asn Leu 
                485                 490                 495     


Asp Gly Ser Tyr Arg Val Thr Leu Ile Thr Glu Asn Leu Gly His Pro 
            500                 505                 510         


Arg Gly Ile Ala Val Asp Pro Thr Val Gly Lys Thr Val Val His Gly 
        515                 520                 525             


Gly Ser Leu Ile Pro His Pro Phe Gly Val Ser Leu Phe Glu Gly Gln 
    530                 535                 540                 


Val Phe Phe Thr Asp Trp Thr Lys Met Ala Val Leu Lys Ala Asn Lys 
545                 550                 555                 560 


Phe Thr Glu Thr Asn Pro Gln Val Tyr Tyr Gln Ala Ser Leu Arg Pro 
                565                 570                 575     


Tyr Gly Val Thr Val Tyr His Ser Leu Arg Gln Pro Tyr Ala Thr Asn 
            580                 585                 590         


Pro Cys Lys Asp Asn Asn Gly Gly Cys Glu Gln Val Cys Val Leu Ser 
        595                 600                 605             


His Arg Thr Asp Asn Asp Gly Leu Gly Phe Arg Cys Lys Cys Thr Phe 
    610                 615                 620                 


Gly Phe Gln Leu Asp Thr Asp Glu Arg His Cys Ile Gly Arg Glu Ile 
625                 630                 635                 640 


Leu Ala Ala Asn Arg Val Glu Asn Val Glu Ser Leu Ala Phe Asp Trp 
                645                 650                 655     


Ile Ser Lys Asn Leu Tyr Trp Thr Asp Ser His Tyr Lys Ser Ile Ser 
            660                 665                 670         


Val Met Arg Leu Ala Asp Lys Thr Arg Arg Thr Val Val Gln Tyr Leu 
        675                 680                 685             


Asn Asn Pro Arg Ser Val Val Val His Pro Phe Ala Gly Tyr Leu Phe 
    690                 695                 700                 


Phe Thr Asp Trp Phe Arg Pro Ala Lys Ile Met Arg Ala Trp Ser Asp 
705                 710                 715                 720 


Gly Ser His Leu Leu Pro Val Ile Asn Thr Thr Leu Gly Trp Pro Asn 
                725                 730                 735     


Gly Leu Ala Ile Asp Trp Ala Ala Ser Arg Leu Tyr Trp Val Asp Ala 
            740                 745                 750         


Tyr Phe Asp Lys Ile Glu His Ser Thr Phe Asp Gly Leu Asp Arg Arg 
        755                 760                 765             


Arg Leu Gly His Ile Glu Gln Met Thr His Pro Phe Gly Leu Ala Ile 
    770                 775                 780                 


Phe Gly Glu His Leu Phe Phe Thr Asp Trp Arg Leu Gly Ala Ile Ile 
785                 790                 795                 800 


Arg Val Arg Lys Ala Asp Gly Gly Glu Met Thr Val Ile Arg Ser Gly 
                805                 810                 815     


Ile Ala Tyr Ile Leu His Leu Lys Ser Tyr Asp Val Asn Ile Gln Thr 
            820                 825                 830         


Gly Ser Asn Ala Cys Asn Gln Pro Thr His Pro Asn Gly Asp Cys Ser 
        835                 840                 845             


His Phe Cys Phe Pro Val Pro Asn Phe Gln Arg Val Cys Gly Cys Pro 
    850                 855                 860                 


Tyr Gly Met Arg Leu Ala Ser Asn His Leu Thr Cys Glu Gly Asp Pro 
865                 870                 875                 880 


Thr Asn Glu Pro Pro Thr Glu Gln Cys Gly Leu Phe Ser Phe Pro Cys 
                885                 890                 895     


Lys Asn Gly Arg Cys Val Pro Asn Tyr Tyr Leu Cys Asp Gly Val Asp 
            900                 905                 910         


Asp Cys His Asp Asn Ser Asp Glu Gln Leu Cys Gly Thr Leu Asn Asn 
        915                 920                 925             


Thr Cys Ser Ser Ser Ala Phe Thr Cys Gly His Gly Glu Cys Ile Pro 
    930                 935                 940                 


Ala His Trp Arg Cys Asp Lys Arg Asn Asp Cys Val Asp Gly Ser Asp 
945                 950                 955                 960 


Glu His Asn Cys Pro Thr His Ala Pro Ala Ser Cys Leu Asp Thr Gln 
                965                 970                 975     


Tyr Thr Cys Asp Asn His Gln Cys Ile Ser Lys Asn Trp Val Cys Asp 
            980                 985                 990         


Thr Asp Asn Asp Cys Gly Asp Gly  Ser Asp Glu Lys Asn  Cys Asn Ser 
        995                 1000                 1005             


Thr Glu  Thr Cys Gln Pro Ser  Gln Phe Asn Cys Pro  Asn His Arg 
    1010                 1015                 1020             


Cys Ile  Asp Leu Ser Phe Val  Cys Asp Gly Asp Lys  Asp Cys Val 
    1025                 1030                 1035             


Asp Gly  Ser Asp Glu Val Gly  Cys Val Leu Asn Cys  Thr Ala Ser 
    1040                 1045                 1050             


Gln Phe  Lys Cys Ala Ser Gly  Asp Lys Cys Ile Gly  Val Thr Asn 
    1055                 1060                 1065             


Arg Cys  Asp Gly Val Phe Asp  Cys Ser Asp Asn Ser  Asp Glu Ala 
    1070                 1075                 1080             


Gly Cys  Pro Thr Arg Pro Pro  Gly Met Cys His Ser  Asp Glu Phe 
    1085                 1090                 1095             


Gln Cys  Gln Glu Asp Gly Ile  Cys Ile Pro Asn Phe  Trp Glu Cys 
    1100                 1105                 1110             


Asp Gly  His Pro Asp Cys Leu  Tyr Gly Ser Asp Glu  His Asn Ala 
    1115                 1120                 1125             


Cys Val  Pro Lys Thr Cys Pro  Ser Ser Tyr Phe His  Cys Asp Asn 
    1130                 1135                 1140             


Gly Asn  Cys Ile His Arg Ala  Trp Leu Cys Asp Arg  Asp Asn Asp 
    1145                 1150                 1155             


Cys Gly  Asp Met Ser Asp Glu  Lys Asp Cys Pro Thr  Gln Pro Phe 
    1160                 1165                 1170             


Arg Cys  Pro Ser Trp Gln Trp  Gln Cys Leu Gly His  Asn Ile Cys 
    1175                 1180                 1185             


Val Asn  Leu Ser Val Val Cys  Asp Gly Ile Phe Asp  Cys Pro Asn 
    1190                 1195                 1200             


Gly Thr  Asp Glu Ser Pro Leu  Cys Ser Lys Phe Pro  Asp His Ser 
    1205                 1210                 1215             


Leu Leu  Ala Ile Asn Ser Phe  
    1220                 1225 


<210>  8018
<211>  1905
<212>  PRT
<213>  Homo Sapiens

<400>  8018

Met Arg Arg Gln Trp Gly Ala Leu Leu Leu Gly Ala Leu Leu Cys Ala 
1               5                   10                  15      


His Gly Leu Ala Ser Ser Pro Glu Cys Ala Cys Gly Arg Ser His Phe 
            20                  25                  30          


Thr Cys Ala Val Ser Ala Leu Gly Glu Cys Thr Cys Ile Pro Ala Gln 
        35                  40                  45              


Trp Gln Cys Asp Gly Asp Asn Asp Cys Gly Asp His Ser Asp Glu Asp 
    50                  55                  60                  


Gly Cys Ile Leu Pro Thr Cys Ser Pro Leu Asp Phe His Cys Asp Asn 
65                  70                  75                  80  


Gly Lys Cys Ile Arg Arg Ser Trp Val Cys Asp Gly Asp Asn Asp Cys 
                85                  90                  95      


Glu Asp Asp Ser Asp Glu Gln Asp Cys Pro Pro Arg Glu Cys Glu Glu 
            100                 105                 110         


Asp Glu Phe Pro Cys Gln Asn Gly Tyr Cys Ile Arg Ser Leu Trp His 
        115                 120                 125             


Cys Asp Gly Asp Asn Asp Cys Gly Asp Asn Ser Asp Glu Gln Cys Asp 
    130                 135                 140                 


Met Arg Lys Cys Ser Asp Lys Glu Phe Arg Cys Ser Asp Gly Ser Cys 
145                 150                 155                 160 


Ile Ala Glu His Trp Tyr Cys Asp Gly Asp Thr Asp Cys Lys Asp Gly 
                165                 170                 175     


Ser Asp Glu Glu Asn Cys Pro Ser Ala Val Pro Ala Pro Pro Cys Asn 
            180                 185                 190         


Leu Glu Glu Phe Gln Cys Ala Tyr Gly Arg Cys Ile Leu Asp Ile Tyr 
        195                 200                 205             


His Cys Asp Gly Asp Asp Asp Cys Gly Asp Trp Ser Asp Glu Ser Asp 
    210                 215                 220                 


Cys Ser Ser His Gln Pro Cys Arg Ser Gly Glu Phe Met Cys Asp Ser 
225                 230                 235                 240 


Gly Leu Cys Ile Asn Ala Gly Trp Arg Cys Asp Gly Asp Ala Asp Cys 
                245                 250                 255     


Asp Asp Gln Ser Asp Glu Arg Asn Cys Thr Thr Ser Met Cys Thr Ala 
            260                 265                 270         


Glu Gln Phe Arg Cys His Ser Gly Arg Cys Val Arg Leu Ser Trp Arg 
        275                 280                 285             


Cys Asp Gly Glu Asp Asp Cys Ala Asp Asn Ser Asp Glu Glu Asn Cys 
    290                 295                 300                 


Glu Asn Thr Gly Ser Pro Gln Cys Ala Leu Asp Gln Phe Leu Cys Trp 
305                 310                 315                 320 


Asn Gly Arg Cys Ile Gly Gln Arg Lys Leu Cys Asn Gly Val Asn Asp 
                325                 330                 335     


Cys Gly Asp Asn Ser Asp Glu Ser Pro Gln Gln Asn Cys Arg Pro Arg 
            340                 345                 350         


Thr Gly Glu Glu Asn Cys Asn Val Asn Asn Gly Gly Cys Ala Gln Lys 
        355                 360                 365             


Cys Gln Met Val Arg Gly Ala Val Gln Cys Thr Cys His Thr Gly Tyr 
    370                 375                 380                 


Arg Leu Thr Glu Asp Gly His Thr Cys Gln Asp Val Asn Glu Cys Ala 
385                 390                 395                 400 


Glu Glu Gly Tyr Cys Ser Gln Gly Cys Thr Asn Ser Glu Gly Ala Phe 
                405                 410                 415     


Gln Cys Trp Cys Glu Thr Gly Tyr Glu Leu Arg Pro Asp Arg Arg Ser 
            420                 425                 430         


Cys Lys Ala Leu Gly Pro Glu Pro Val Leu Leu Phe Ala Asn Arg Ile 
        435                 440                 445             


Asp Ile Arg Gln Val Leu Pro His Arg Ser Glu Tyr Thr Leu Leu Leu 
    450                 455                 460                 


Asn Asn Leu Glu Asn Ala Ile Ala Leu Asp Phe His His Arg Arg Glu 
465                 470                 475                 480 


Leu Val Phe Trp Ser Asp Val Thr Leu Asp Arg Ile Leu Arg Ala Asn 
                485                 490                 495     


Leu Asn Gly Ser Asn Val Glu Glu Val Val Ser Thr Gly Leu Glu Ser 
            500                 505                 510         


Pro Gly Gly Leu Ala Val Asp Trp Val His Asp Lys Leu Tyr Trp Thr 
        515                 520                 525             


Asp Ser Gly Thr Ser Arg Ile Glu Val Ala Asn Leu Asp Gly Ala His 
    530                 535                 540                 


Arg Lys Val Leu Leu Trp Gln Asn Leu Glu Lys Pro Arg Ala Ile Ala 
545                 550                 555                 560 


Leu His Pro Met Glu Gly Thr Ile Tyr Trp Thr Asp Trp Gly Asn Thr 
                565                 570                 575     


Pro Arg Ile Glu Ala Ser Ser Met Asp Gly Ser Gly Arg Arg Ile Ile 
            580                 585                 590         


Ala Asp Thr His Leu Phe Trp Pro Asn Gly Leu Thr Ile Asp Tyr Ala 
        595                 600                 605             


Gly Arg Arg Met Tyr Trp Val Asp Ala Lys His His Val Ile Glu Arg 
    610                 615                 620                 


Ala Asn Leu Asp Gly Ser His Arg Lys Ala Val Ile Ser Gln Gly Leu 
625                 630                 635                 640 


Pro His Pro Phe Ala Ile Thr Val Phe Glu Asp Ser Leu Tyr Trp Thr 
                645                 650                 655     


Asp Trp His Thr Lys Ser Ile Asn Ser Ala Asn Lys Phe Thr Gly Lys 
            660                 665                 670         


Asn Gln Glu Ile Ile Arg Asn Lys Leu His Phe Pro Met Asp Ile His 
        675                 680                 685             


Thr Leu His Pro Gln Arg Gln Pro Ala Gly Lys Asn Arg Cys Gly Asp 
    690                 695                 700                 


Asn Asn Gly Gly Cys Thr His Leu Cys Leu Pro Ser Gly Gln Asn Tyr 
705                 710                 715                 720 


Thr Cys Ala Cys Pro Thr Gly Phe Arg Lys Ile Ser Ser His Ala Cys 
                725                 730                 735     


Ala Gln Ser Leu Asp Lys Phe Leu Leu Phe Ala Arg Arg Met Asp Ile 
            740                 745                 750         


Arg Arg Ile Ser Phe Asp Thr Glu Asp Leu Ser Asp Asp Val Ile Pro 
        755                 760                 765             


Leu Ala Asp Val Arg Ser Ala Val Ala Leu Asp Trp Asp Ser Arg Asp 
    770                 775                 780                 


Asp His Val Tyr Trp Thr Asp Val Ser Thr Asp Thr Ile Ser Arg Ala 
785                 790                 795                 800 


Lys Trp Asp Gly Thr Gly Gln Glu Val Val Val Asp Thr Ser Leu Glu 
                805                 810                 815     


Ser Pro Ala Gly Leu Ala Ile Asp Trp Val Thr Asn Lys Leu Tyr Trp 
            820                 825                 830         


Thr Asp Ala Gly Thr Asp Arg Ile Glu Val Ala Asn Thr Asp Gly Ser 
        835                 840                 845             


Met Arg Thr Val Leu Ile Trp Glu Asn Leu Asp Arg Pro Arg Asp Ile 
    850                 855                 860                 


Val Val Glu Pro Met Gly Gly Tyr Met Tyr Trp Thr Asp Trp Gly Ala 
865                 870                 875                 880 


Ser Pro Lys Ile Glu Arg Ala Gly Met Asp Ala Ser Gly Arg Gln Val 
                885                 890                 895     


Ile Ile Ser Ser Asn Leu Thr Trp Pro Asn Gly Leu Ala Ile Asp Tyr 
            900                 905                 910         


Gly Ser Gln Arg Leu Tyr Trp Ala Asp Ala Gly Met Lys Thr Ile Glu 
        915                 920                 925             


Phe Ala Gly Leu Asp Gly Ser Lys Arg Lys Val Leu Ile Gly Ser Gln 
    930                 935                 940                 


Leu Pro His Pro Phe Gly Leu Thr Leu Tyr Gly Glu Arg Ile Tyr Trp 
945                 950                 955                 960 


Thr Asp Trp Gln Thr Lys Ser Ile Gln Ser Ala Asp Arg Leu Thr Gly 
                965                 970                 975     


Leu Asp Arg Glu Thr Leu Gln Glu Asn Leu Glu Asn Leu Met Asp Ile 
            980                 985                 990         


His Val Phe His Arg Arg Arg Pro  Pro Val Ser Thr Pro  Cys Ala Met 
        995                 1000                 1005             


Glu Asn  Gly Gly Cys Ser His  Leu Cys Leu Arg Ser  Pro Asn Pro 
    1010                 1015                 1020             


Ser Gly  Phe Ser Cys Thr Cys  Pro Thr Gly Ile Asn  Leu Leu Ser 
    1025                 1030                 1035             


Asp Gly  Lys Thr Cys Ser Pro  Gly Met Asn Ser Phe  Leu Ile Phe 
    1040                 1045                 1050             


Ala Arg  Arg Ile Asp Ile Arg  Met Val Ser Leu Asp  Ile Pro Tyr 
    1055                 1060                 1065             


Phe Ala  Asp Val Val Val Pro  Ile Asn Ile Thr Met  Lys Asn Thr 
    1070                 1075                 1080             


Ile Ala  Ile Gly Val Asp Pro  Gln Glu Gly Lys Val  Tyr Trp Ser 
    1085                 1090                 1095             


Asp Ser  Thr Leu His Arg Ile  Ser Arg Ala Asn Leu  Asp Gly Ser 
    1100                 1105                 1110             


Gln His  Glu Asp Ile Ile Thr  Thr Gly Leu Gln Thr  Thr Asp Gly 
    1115                 1120                 1125             


Leu Ala  Val Asp Ala Ile Gly  Arg Lys Val Tyr Trp  Thr Asp Thr 
    1130                 1135                 1140             


Gly Thr  Asn Arg Ile Glu Val  Gly Asn Leu Asp Gly  Ser Met Arg 
    1145                 1150                 1155             


Lys Val  Leu Val Trp Gln Asn  Leu Asp Ser Pro Arg  Ala Ile Val 
    1160                 1165                 1170             


Leu Tyr  His Glu Met Gly Phe  Met Tyr Trp Thr Asp  Trp Gly Glu 
    1175                 1180                 1185             


Asn Ala  Lys Leu Glu Arg Ser  Gly Met Asp Gly Ser  Asp Arg Ala 
    1190                 1195                 1200             


Val Leu  Ile Asn Asn Asn Leu  Gly Trp Pro Asn Gly  Leu Thr Val 
    1205                 1210                 1215             


Asp Lys  Ala Ser Ser Gln Leu  Leu Trp Ala Asp Ala  His Thr Glu 
    1220                 1225                 1230             


Arg Ile  Glu Ala Ala Asp Leu  Asn Gly Ala Asn Arg  His Thr Leu 
    1235                 1240                 1245             


Val Ser  Pro Val Gln His Pro  Tyr Gly Leu Thr Leu  Leu Asp Ser 
    1250                 1255                 1260             


Tyr Ile  Tyr Trp Thr Asp Trp  Gln Thr Arg Ser Ile  His Arg Ala 
    1265                 1270                 1275             


Asp Lys  Gly Thr Gly Ser Asn  Val Ile Leu Val Arg  Ser Asn Leu 
    1280                 1285                 1290             


Pro Gly  Leu Met Asp Met Gln  Ala Val Asp Arg Ala  Gln Pro Leu 
    1295                 1300                 1305             


Gly Phe  Asn Lys Cys Gly Ser  Arg Asn Gly Gly Cys  Ser His Leu 
    1310                 1315                 1320             


Cys Leu  Pro Arg Pro Ser Gly  Phe Ser Cys Ala Cys  Pro Thr Gly 
    1325                 1330                 1335             


Ile Gln  Leu Lys Gly Asp Gly  Lys Thr Cys Asp Pro  Ser Pro Glu 
    1340                 1345                 1350             


Thr Tyr  Leu Leu Phe Ser Ser  Arg Gly Ser Ile Arg  Arg Ile Ser 
    1355                 1360                 1365             


Leu Asp  Thr Ser Asp His Thr  Asp Val His Val Pro  Val Pro Glu 
    1370                 1375                 1380             


Leu Asn  Asn Val Ile Ser Leu  Asp Tyr Asp Ser Val  Asp Gly Lys 
    1385                 1390                 1395             


Val Tyr  Tyr Thr Asp Val Phe  Leu Asp Val Ile Arg  Arg Ala Asp 
    1400                 1405                 1410             


Leu Asn  Gly Ser Asn Met Glu  Thr Val Ile Gly Arg  Gly Leu Lys 
    1415                 1420                 1425             


Thr Thr  Asp Gly Leu Ala Val  Asp Trp Val Ala Arg  Asn Leu Tyr 
    1430                 1435                 1440             


Trp Thr  Asp Thr Gly Arg Asn  Thr Ile Glu Ala Ser  Arg Leu Asp 
    1445                 1450                 1455             


Gly Ser  Cys Arg Lys Val Leu  Ile Asn Asn Ser Leu  Asp Glu Pro 
    1460                 1465                 1470             


Arg Ala  Ile Ala Val Phe Pro  Arg Lys Gly Tyr Leu  Phe Trp Thr 
    1475                 1480                 1485             


Asp Trp  Gly His Ile Ala Lys  Ile Glu Arg Ala Asn  Leu Asp Gly 
    1490                 1495                 1500             


Ser Glu  Arg Lys Val Leu Ile  Asn Thr Asp Leu Gly  Trp Pro Asn 
    1505                 1510                 1515             


Gly Leu  Thr Leu Asp Tyr Asp  Thr Arg Arg Ile Tyr  Trp Val Asp 
    1520                 1525                 1530             


Ala His  Leu Asp Arg Ile Glu  Ser Ala Asp Leu Asn  Gly Lys Leu 
    1535                 1540                 1545             


Arg Gln  Val Leu Val Ser His  Val Ser His Pro Phe  Ala Leu Thr 
    1550                 1555                 1560             


Gln Gln  Asp Arg Trp Ile Tyr  Trp Thr Asp Trp Gln  Thr Lys Ser 
    1565                 1570                 1575             


Ile Gln  Arg Val Asp Lys Tyr  Ser Gly Arg Asn Lys  Glu Thr Val 
    1580                 1585                 1590             


Leu Ala  Asn Val Glu Gly Leu  Met Asp Ile Ile Val  Val Ser Pro 
    1595                 1600                 1605             


Gln Arg  Gln Thr Gly Thr Asn  Ala Cys Gly Val Asn  Asn Gly Gly 
    1610                 1615                 1620             


Cys Thr  His Leu Cys Phe Ala  Arg Ala Ser Asp Phe  Val Cys Ala 
    1625                 1630                 1635             


Cys Pro  Asp Glu Pro Asp Ser  Arg Pro Cys Ser Leu  Val Pro Gly 
    1640                 1645                 1650             


Leu Val  Pro Pro Ala Pro Arg  Ala Thr Gly Met Ser  Glu Lys Ser 
    1655                 1660                 1665             


Pro Val  Leu Pro Asn Thr Pro  Pro Thr Thr Leu Tyr  Ser Ser Thr 
    1670                 1675                 1680             


Thr Arg  Thr Arg Thr Ser Leu  Glu Glu Val Glu Gly  Arg Cys Ser 
    1685                 1690                 1695             


Glu Arg  Asp Ala Arg Leu Gly  Leu Cys Ala Arg Ser  Asn Asp Ala 
    1700                 1705                 1710             


Val Pro  Ala Ala Pro Gly Glu  Gly Leu His Ile Ser  Tyr Ala Ile 
    1715                 1720                 1725             


Gly Gly  Leu Leu Ser Ile Leu  Leu Ile Leu Val Val  Ile Ala Ala 
    1730                 1735                 1740             


Leu Met  Leu Tyr Arg His Lys  Lys Ser Lys Phe Thr  Asp Pro Gly 
    1745                 1750                 1755             


Met Gly  Asn Leu Thr Tyr Ser  Asn Pro Ser Tyr Arg  Thr Ser Thr 
    1760                 1765                 1770             


Gln Glu  Val Lys Ile Glu Ala  Ile Pro Lys Pro Ala  Met Tyr Asn 
    1775                 1780                 1785             


Gln Leu  Cys Tyr Lys Lys Glu  Gly Gly Pro Asp His  Asn Tyr Thr 
    1790                 1795                 1800             


Lys Glu  Lys Ile Lys Ile Val  Glu Gly Ile Cys Leu  Leu Ser Gly 
    1805                 1810                 1815             


Asp Asp  Ala Glu Trp Asp Asp  Leu Lys Gln Leu Arg  Ser Ser Arg 
    1820                 1825                 1830             


Gly Gly  Leu Leu Arg Asp His  Val Cys Met Lys Thr  Asp Thr Val 
    1835                 1840                 1845             


Ser Ile  Gln Ala Ser Ser Gly  Ser Leu Asp Asp Thr  Glu Thr Glu 
    1850                 1855                 1860             


Gln Leu  Leu Gln Glu Glu Gln  Ser Glu Cys Ser Ser  Val His Thr 
    1865                 1870                 1875             


Ala Ala  Thr Pro Glu Arg Arg  Gly Ser Leu Pro Asp  Thr Gly Trp 
    1880                 1885                 1890             


Lys His  Glu Arg Lys Leu Ser  Ser Glu Ser Gln Val  
    1895                 1900                 1905 


<210>  8019
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  8019

Met Arg Arg Gln Trp Gly Ala Leu Leu Leu Gly Ala Leu Leu Cys Ala 
1               5                   10                  15      


His Val Leu Pro Thr Cys Ser Pro Leu Asp Phe His Cys Asp Asn Gly 
            20                  25                  30          


Lys Cys Ile Arg Arg Ser Trp Val Cys Asp Gly Asp Asn Asp Cys Glu 
        35                  40                  45              


Asp Asp Ser Asp Glu Gln Asp Cys Pro Pro Arg Glu Cys Glu Glu Asp 
    50                  55                  60                  


Glu Phe Pro Cys Gln Asn Gly Tyr Cys Ile Arg Ser Leu Trp His Cys 
65                  70                  75                  80  


Asp Gly Asp Asn Asp Cys Gly Asp Asn Ser Asp Glu Gln Cys Asp Met 
                85                  90                  95      


Arg Lys Cys Ser Asp Lys Glu Phe Arg Cys Ser Asp Gly Ser Cys Ile 
            100                 105                 110         


Ala Glu His Trp Tyr Cys Asp Gly Asp Thr Asp Cys Lys Asp Gly Ser 
        115                 120                 125             


Asp Glu Glu Asn Cys 
    130             


<210>  8020
<211>  357
<212>  PRT
<213>  Homo Sapiens

<400>  8020

Met Ala Pro Arg Arg Val Arg Ser Phe Leu Arg Gly Leu Pro Ala Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Phe Leu Gly Pro Trp Pro Ala Ala Ser His Gly 
            20                  25                  30          


Gly Lys Tyr Ser Arg Glu Lys Asn Gln Pro Lys Pro Ser Pro Lys Arg 
        35                  40                  45              


Glu Ser Gly Glu Glu Phe Arg Met Glu Lys Leu Asn Gln Leu Trp Glu 
    50                  55                  60                  


Lys Ala Gln Arg Leu His Leu Pro Pro Val Arg Leu Ala Glu Leu His 
65                  70                  75                  80  


Ala Asp Leu Lys Ile Gln Glu Arg Asp Glu Leu Ala Trp Lys Lys Leu 
                85                  90                  95      


Lys Leu Asp Gly Leu Asp Glu Asp Gly Glu Lys Glu Ala Arg Leu Ile 
            100                 105                 110         


Arg Asn Leu Asn Val Ile Leu Ala Lys Tyr Gly Leu Asp Gly Lys Lys 
        115                 120                 125             


Asp Ala Arg Gln Val Thr Ser Asn Ser Leu Ser Gly Thr Gln Glu Asp 
    130                 135                 140                 


Gly Leu Asp Asp Pro Arg Leu Glu Lys Leu Trp His Lys Ala Lys Thr 
145                 150                 155                 160 


Ser Gly Lys Phe Ser Gly Glu Glu Leu Asp Lys Leu Trp Arg Glu Phe 
                165                 170                 175     


Leu His His Lys Glu Lys Val His Glu Tyr Asn Val Leu Leu Glu Thr 
            180                 185                 190         


Leu Ser Arg Thr Glu Glu Ile His Glu Asn Val Ile Ser Pro Ser Asp 
        195                 200                 205             


Leu Ser Asp Ile Lys Gly Ser Val Leu His Ser Arg His Thr Glu Leu 
    210                 215                 220                 


Lys Glu Lys Leu Arg Ser Ile Asn Gln Gly Leu Asp Arg Leu Arg Arg 
225                 230                 235                 240 


Val Ser His Gln Gly Tyr Ser Thr Glu Ala Glu Phe Glu Glu Pro Arg 
                245                 250                 255     


Val Ile Asp Leu Trp Asp Leu Ala Gln Ser Ala Asn Leu Thr Asp Lys 
            260                 265                 270         


Glu Leu Glu Ala Phe Arg Glu Glu Leu Lys His Phe Glu Ala Lys Ile 
        275                 280                 285             


Glu Lys His Asn His Tyr Gln Lys Gln Leu Glu Ile Ala His Glu Lys 
    290                 295                 300                 


Leu Arg His Ala Glu Ser Val Gly Asp Gly Glu Arg Val Ser Arg Ser 
305                 310                 315                 320 


Arg Glu Lys His Ala Leu Leu Glu Gly Arg Thr Lys Glu Leu Gly Tyr 
                325                 330                 335     


Thr Val Lys Lys His Leu Gln Asp Leu Ser Gly Arg Ile Ser Arg Ala 
            340                 345                 350         


Arg His Asn Glu Leu 
        355         


<210>  8021
<211>  105
<212>  PRT
<213>  Homo Sapiens

<400>  8021

Met Ala Pro Arg Arg Val Arg Ser Phe Leu Arg Gly Leu Pro Ala Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Phe Leu Gly Pro Trp Pro Ala Ala Ser His Gly 
            20                  25                  30          


Gly Lys Tyr Ser Arg Glu Lys Asn Gln Pro Lys Pro Ser Pro Lys Arg 
        35                  40                  45              


Glu Ser Gly Glu Glu Phe Arg Met Glu Lys Leu Asn Gln Leu Trp Glu 
    50                  55                  60                  


Lys Ala Gln Arg Asn Leu Pro Val Ala Ser Leu Leu Arg Gly Gln Phe 
65                  70                  75                  80  


Leu Ala Val Ser Trp Ser Val Leu Leu Val Ala His Arg Leu Leu Pro 
                85                  90                  95      


Phe Val Arg Ser Cys Ile Phe Leu Pro 
            100                 105 


<210>  8022
<211>  104
<212>  PRT
<213>  Homo Sapiens

<400>  8022

Met Arg Val Val Thr Ile Val Ile Leu Leu Cys Phe Cys Lys Ala Ala 
1               5                   10                  15      


Glu Leu Arg Lys Ala Ser Pro Gly Ser Val Arg Ser Arg Val Asn His 
            20                  25                  30          


Gly Arg Ala Gly Gly Gly Arg Arg Gly Ser Asn Pro Val Lys Arg Tyr 
        35                  40                  45              


Ala Pro Gly Leu Pro Cys Asp Val Tyr Thr Tyr Leu His Glu Lys Tyr 
    50                  55                  60                  


Leu Asp Cys Gln Glu Arg Lys Leu Val Tyr Val Leu Pro Gly Trp Pro 
65                  70                  75                  80  


Gln Asp Leu Leu His Met Leu Leu Ala Arg Asn Lys Ile Arg Thr Leu 
                85                  90                  95      


Lys Asn Asn Met Phe Ser Lys Phe 
            100                 


<210>  8023
<211>  313
<212>  PRT
<213>  Homo Sapiens

<400>  8023

Met Arg Val Val Thr Ile Val Ile Leu Leu Cys Phe Cys Lys Ala Ala 
1               5                   10                  15      


Glu Leu Arg Lys Ala Ser Pro Gly Ser Val Arg Ser Arg Val Asn His 
            20                  25                  30          


Gly Arg Ala Gly Gly Gly Arg Arg Gly Ser Asn Pro Val Lys Arg Tyr 
        35                  40                  45              


Ala Pro Gly Leu Pro Cys Asp Val Tyr Thr Tyr Leu His Glu Lys Tyr 
    50                  55                  60                  


Leu Asp Cys Gln Glu Arg Lys Leu Val Tyr Val Leu Pro Gly Trp Pro 
65                  70                  75                  80  


Gln Asp Leu Leu His Met Leu Leu Ala Arg Asn Lys Ile Arg Thr Leu 
                85                  90                  95      


Lys Asn Asn Met Phe Ser Lys Phe Lys Lys Leu Lys Ser Leu Asp Leu 
            100                 105                 110         


Gln Gln Asn Glu Ile Ser Lys Ile Glu Ser Glu Ala Phe Phe Gly Leu 
        115                 120                 125             


Asn Lys Leu Thr Thr Leu Leu Leu Gln His Asn Gln Ile Lys Val Leu 
    130                 135                 140                 


Thr Glu Glu Val Phe Ile Tyr Thr Pro Leu Leu Ser Tyr Leu Arg Leu 
145                 150                 155                 160 


Tyr Asp Asn Pro Trp His Cys Thr Cys Glu Ile Glu Thr Leu Ile Ser 
                165                 170                 175     


Met Leu Gln Ile Pro Arg Asn Arg Asn Leu Gly Asn Tyr Ala Lys Cys 
            180                 185                 190         


Glu Ser Pro Gln Glu Gln Lys Asn Lys Lys Leu Arg Gln Ile Lys Ser 
        195                 200                 205             


Glu Gln Leu Cys Asn Glu Glu Glu Lys Glu Gln Leu Asp Pro Lys Pro 
    210                 215                 220                 


Gln Val Ser Gly Arg Pro Pro Val Ile Lys Pro Glu Val Asp Ser Thr 
225                 230                 235                 240 


Phe Cys His Asn Tyr Val Phe Pro Ile Gln Thr Leu Asp Cys Lys Arg 
                245                 250                 255     


Lys Glu Leu Lys Lys Val Pro Asn Asn Ile Pro Pro Asp Ile Val Lys 
            260                 265                 270         


Leu Asp Leu Ser Tyr Asn Lys Ile Asn Gln Leu Arg Pro Lys Glu Phe 
        275                 280                 285             


Glu Asp Val His Glu Leu Lys Lys Leu Asn Leu Ser Ser Asn Gly Ile 
    290                 295                 300                 


Glu Phe Ile Asp Pro Gly Ser Leu Arg 
305                 310             


<210>  8024
<211>  441
<212>  PRT
<213>  Homo Sapiens

<400>  8024

Met Arg Val Val Thr Ile Val Ile Leu Leu Cys Phe Cys Lys Ala Ala 
1               5                   10                  15      


Glu Leu Arg Lys Ala Ser Pro Gly Ser Val Arg Ser Arg Val Asn His 
            20                  25                  30          


Gly Arg Ala Gly Gly Gly Arg Arg Gly Ser Asn Pro Val Lys Arg Tyr 
        35                  40                  45              


Ala Pro Gly Leu Pro Cys Asp Val Tyr Thr Tyr Leu His Glu Lys Tyr 
    50                  55                  60                  


Leu Asp Cys Gln Glu Arg Lys Leu Val Tyr Val Leu Pro Gly Trp Pro 
65                  70                  75                  80  


Gln Asp Leu Leu His Met Leu Leu Ala Arg Asn Lys Ile Arg Thr Leu 
                85                  90                  95      


Lys Asn Asn Met Phe Ser Lys Phe Lys Lys Leu Lys Ser Leu Asp Leu 
            100                 105                 110         


Gln Gln Asn Glu Ile Ser Lys Ile Glu Ser Glu Ala Phe Phe Gly Leu 
        115                 120                 125             


Asn Lys Leu Thr Thr Leu Leu Leu Gln His Asn Gln Ile Lys Val Leu 
    130                 135                 140                 


Thr Glu Glu Val Phe Ile Tyr Thr Pro Leu Leu Ser Tyr Leu Arg Leu 
145                 150                 155                 160 


Tyr Asp Asn Pro Trp His Cys Thr Cys Glu Ile Glu Thr Leu Ile Ser 
                165                 170                 175     


Met Leu Gln Ile Pro Arg Asn Arg Asn Leu Gly Asn Tyr Ala Lys Cys 
            180                 185                 190         


Glu Ser Pro Gln Glu Gln Lys Asn Lys Lys Leu Arg Gln Ile Lys Ser 
        195                 200                 205             


Glu Gln Leu Cys Asn Glu Glu Glu Lys Glu Gln Leu Asp Pro Lys Pro 
    210                 215                 220                 


Gln Val Ser Gly Arg Pro Pro Val Ile Lys Pro Glu Val Asp Ser Thr 
225                 230                 235                 240 


Phe Cys His Asn Tyr Val Phe Pro Ile Gln Thr Leu Asp Cys Lys Arg 
                245                 250                 255     


Lys Glu Leu Lys Lys Val Pro Asn Asn Ile Pro Pro Asp Ile Val Lys 
            260                 265                 270         


Leu Asp Leu Ser Tyr Asn Lys Ile Asn Gln Leu Arg Pro Lys Glu Phe 
        275                 280                 285             


Glu Asp Val His Glu Leu Lys Lys Leu Asn Leu Ser Ser Asn Gly Ile 
    290                 295                 300                 


Glu Phe Ile Asp Pro Ala Ala Phe Leu Gly Leu Thr His Leu Glu Glu 
305                 310                 315                 320 


Leu Asp Leu Ser Asn Asn Ser Leu Gln Asn Phe Asp Tyr Gly Val Leu 
                325                 330                 335     


Glu Asp Leu Tyr Phe Leu Lys Leu Leu Trp Leu Arg Asp Asn Pro Trp 
            340                 345                 350         


Arg Cys Asp Tyr Asn Ile His Tyr Leu Tyr Tyr Trp Leu Lys His His 
        355                 360                 365             


Tyr Asn Val His Phe Asn Gly Leu Glu Cys Lys Thr Pro Glu Glu Tyr 
    370                 375                 380                 


Lys Gly Trp Ser Val Gly Lys Tyr Ile Arg Ser Tyr Tyr Glu Glu Cys 
385                 390                 395                 400 


Pro Lys Asp Lys Leu Pro Ala Tyr Pro Glu Ser Phe Asp Gln Asp Thr 
                405                 410                 415     


Glu Asp Asp Glu Trp Glu Lys Lys His Arg Asp His Thr Ala Lys Lys 
            420                 425                 430         


Gln Ser Val Ile Ile Thr Ile Val Gly 
        435                 440     


<210>  8025
<211>  186
<212>  PRT
<213>  Homo Sapiens

<400>  8025

Met Arg Pro Gln Ile Leu Leu Leu Leu Ala Leu Leu Thr Leu Gly Leu 
1               5                   10                  15      


Ala Ala Gln His Gln Asp Lys Val Pro Cys Lys Met Val Asp Lys Lys 
            20                  25                  30          


Val Ser Cys Gln Val Leu Gly Leu Leu Gln Val Pro Ser Val Leu Pro 
        35                  40                  45              


Pro Asp Thr Glu Thr Leu Asp Leu Ser Gly Asn Gln Leu Arg Ser Ile 
    50                  55                  60                  


Leu Ala Ser Pro Leu Gly Phe Tyr Thr Ala Leu Arg His Leu Asp Leu 
65                  70                  75                  80  


Ser Thr Asn Glu Ile Ser Phe Leu Gln Pro Gly Ala Phe Gln Ala Leu 
                85                  90                  95      


Thr His Leu Glu His Leu Ser Leu Ala His Asn Arg Leu Ala Met Ala 
            100                 105                 110         


Thr Ala Leu Ser Ala Gly Gly Leu Gly Pro Leu Pro Arg Val Thr Ser 
        115                 120                 125             


Leu Asp Leu Ser Gly Asn Ser Leu Tyr Ser Gly Leu Leu Glu Arg Leu 
    130                 135                 140                 


Leu Gly Glu Ala Pro Ser Leu His Thr Leu Ser Leu Ala Glu Asn Ser 
145                 150                 155                 160 


Leu Thr Arg Leu Thr Arg His Thr Phe Arg Asp Met Pro Ala Leu Glu 
                165                 170                 175     


Gln Leu Asp Leu His Ser Asn Val Leu Met 
            180                 185     


<210>  8026
<211>  662
<212>  PRT
<213>  Homo Sapiens

<400>  8026

Met Arg Pro Gln Ile Leu Leu Leu Leu Ala Leu Leu Thr Leu Gly Leu 
1               5                   10                  15      


Ala Ala Gln His Gln Asp Lys Val Pro Cys Lys Met Val Asp Lys Lys 
            20                  25                  30          


Val Ser Cys Gln Val Leu Gly Leu Leu Gln Val Pro Ser Val Leu Pro 
        35                  40                  45              


Pro Asp Thr Glu Thr Leu Asp Leu Ser Gly Asn Gln Leu Arg Ser Ile 
    50                  55                  60                  


Leu Ala Ser Pro Leu Gly Phe Tyr Thr Ala Leu Arg His Leu Asp Leu 
65                  70                  75                  80  


Ser Thr Asn Glu Ile Ser Phe Leu Gln Pro Gly Ala Phe Gln Ala Leu 
                85                  90                  95      


Thr His Leu Glu His Leu Ser Leu Ala His Asn Arg Leu Ala Met Ala 
            100                 105                 110         


Thr Ala Leu Ser Ala Gly Gly Leu Gly Pro Leu Pro Arg Val Thr Ser 
        115                 120                 125             


Leu Asp Leu Ser Gly Asn Ser Leu Tyr Ser Gly Leu Leu Glu Arg Leu 
    130                 135                 140                 


Leu Gly Glu Ala Pro Ser Leu His Thr Leu Ser Leu Ala Glu Asn Ser 
145                 150                 155                 160 


Leu Thr Arg Leu Thr Arg His Thr Phe Arg Asp Met Pro Ala Leu Glu 
                165                 170                 175     


Gln Leu Asp Leu His Ser Asn Val Leu Met Asp Ile Glu Asp Gly Ala 
            180                 185                 190         


Phe Glu Gly Leu Pro Arg Leu Thr His Leu Asn Leu Ser Arg Asn Ser 
        195                 200                 205             


Leu Thr Cys Ile Ser Asp Phe Ser Leu Gln Gln Leu Arg Val Leu Asp 
    210                 215                 220                 


Leu Ser Cys Asn Ser Ile Glu Ala Phe Gln Thr Ala Ser Gln Pro Gln 
225                 230                 235                 240 


Ala Glu Phe Gln Leu Thr Trp Leu Asp Leu Arg Glu Asn Lys Leu Leu 
                245                 250                 255     


His Phe Pro Asp Leu Ala Ala Leu Pro Arg Leu Ile Tyr Leu Asn Leu 
            260                 265                 270         


Ser Asn Asn Leu Ile Arg Leu Pro Thr Gly Pro Pro Gln Asp Ser Lys 
        275                 280                 285             


Gly Ile His Ala Pro Ser Glu Gly Trp Ser Ala Leu Pro Leu Ser Ala 
    290                 295                 300                 


Pro Ser Gly Asn Ala Ser Gly Arg Pro Leu Ser Gln Leu Leu Asn Leu 
305                 310                 315                 320 


Asp Leu Ser Tyr Asn Glu Ile Glu Leu Ile Pro Asp Ser Phe Leu Glu 
                325                 330                 335     


His Leu Thr Ser Leu Cys Phe Leu Asn Leu Ser Arg Asn Cys Leu Arg 
            340                 345                 350         


Thr Phe Glu Ala Arg Arg Leu Gly Ser Leu Pro Cys Leu Met Leu Leu 
        355                 360                 365             


Asp Leu Ser His Asn Ala Leu Glu Thr Leu Glu Leu Gly Ala Arg Ala 
    370                 375                 380                 


Leu Gly Ser Leu Arg Thr Leu Leu Leu Gln Gly Asn Ala Leu Arg Asp 
385                 390                 395                 400 


Leu Pro Pro Tyr Thr Phe Ala Asn Leu Ala Ser Leu Gln Arg Leu Asn 
                405                 410                 415     


Leu Gln Gly Asn Arg Val Ser Pro Cys Gly Gly Pro Asp Glu Pro Gly 
            420                 425                 430         


Pro Ser Gly Cys Val Ala Phe Ser Gly Ile Thr Ser Leu Arg Ser Leu 
        435                 440                 445             


Ser Leu Val Asp Asn Glu Ile Glu Leu Leu Arg Ala Gly Ala Phe Leu 
    450                 455                 460                 


His Thr Pro Leu Thr Glu Leu Asp Leu Ser Ser Asn Pro Gly Leu Glu 
465                 470                 475                 480 


Val Ala Thr Gly Ala Leu Gly Gly Leu Glu Ala Ser Leu Glu Val Leu 
                485                 490                 495     


Ala Leu Gln Gly Asn Gly Leu Met Val Leu Gln Val Asp Leu Pro Cys 
            500                 505                 510         


Phe Ile Cys Leu Lys Arg Leu Asn Leu Ala Glu Asn Arg Leu Ser His 
        515                 520                 525             


Leu Pro Ala Trp Thr Gln Ala Val Ser Leu Glu Val Leu Asp Leu Arg 
    530                 535                 540                 


Asn Asn Ser Phe Ser Leu Leu Pro Gly Ser Ala Met Gly Gly Leu Glu 
545                 550                 555                 560 


Thr Ser Leu Arg Arg Leu Tyr Leu Gln Gly Asn Pro Leu Ser Cys Cys 
                565                 570                 575     


Gly Asn Gly Trp Leu Ala Ala Gln Leu His Gln Gly Arg Val Asp Val 
            580                 585                 590         


Asp Ala Thr Gln Asp Leu Ile Cys Arg Phe Ser Ser Gln Glu Glu Val 
        595                 600                 605             


Ser Leu Ser His Val Arg Pro Glu Asp Cys Glu Lys Gly Gly Leu Lys 
    610                 615                 620                 


Asn Ile Asn Leu Ile Ile Ile Leu Thr Phe Ile Leu Val Ser Ala Ile 
625                 630                 635                 640 


Leu Leu Thr Thr Leu Ala Ala Cys Cys Cys Val Arg Arg Gln Lys Phe 
                645                 650                 655     


Asn Gln Gln Tyr Lys Ala 
            660         


<210>  8027
<211>  662
<212>  PRT
<213>  Homo Sapiens

<400>  8027

Met Arg Pro Gln Ile Leu Leu Leu Leu Ala Leu Leu Thr Leu Gly Leu 
1               5                   10                  15      


Ala Ala Gln His Gln Asp Lys Val Pro Cys Lys Met Val Asp Lys Lys 
            20                  25                  30          


Val Ser Cys Gln Val Leu Gly Leu Leu Gln Val Pro Ser Val Leu Pro 
        35                  40                  45              


Pro Asp Thr Glu Thr Leu Asp Leu Ser Gly Asn Gln Leu Arg Ser Ile 
    50                  55                  60                  


Leu Ala Ser Pro Leu Gly Phe Tyr Thr Ala Leu Arg His Leu Asp Leu 
65                  70                  75                  80  


Ser Thr Asn Glu Ile Ser Phe Leu Gln Pro Gly Ala Phe Gln Ala Leu 
                85                  90                  95      


Thr His Leu Glu His Leu Ser Leu Ala His Asn Arg Leu Ala Met Ala 
            100                 105                 110         


Thr Ala Leu Ser Ala Gly Gly Leu Gly Pro Leu Pro Arg Val Thr Ser 
        115                 120                 125             


Leu Asp Leu Ser Gly Asn Ser Leu Tyr Ser Gly Leu Leu Glu Arg Leu 
    130                 135                 140                 


Leu Gly Glu Ala Pro Ser Leu His Thr Leu Ser Leu Ala Glu Asn Ser 
145                 150                 155                 160 


Leu Thr Arg Leu Thr Arg His Thr Phe Arg Asp Met Pro Ala Leu Glu 
                165                 170                 175     


Gln Leu Asp Leu His Ser Asn Val Leu Met Asp Ile Glu Asp Gly Ala 
            180                 185                 190         


Phe Glu Gly Leu Pro Arg Leu Thr His Leu Asn Leu Ser Arg Asn Ser 
        195                 200                 205             


Leu Thr Cys Ile Ser Asp Phe Ser Leu Gln Gln Leu Arg Val Leu Asp 
    210                 215                 220                 


Leu Ser Cys Asn Ser Ile Glu Ala Phe Gln Thr Ala Ser Gln Pro Gln 
225                 230                 235                 240 


Ala Glu Phe Gln Leu Thr Trp Leu Asp Leu Arg Glu Asn Lys Leu Leu 
                245                 250                 255     


His Phe Pro Asp Leu Ala Ala Leu Pro Arg Leu Ile Tyr Leu Asn Leu 
            260                 265                 270         


Ser Asn Asn Leu Ile Arg Leu Pro Thr Gly Pro Pro Gln Asp Ser Lys 
        275                 280                 285             


Gly Ile His Ala Pro Ser Glu Gly Trp Ser Ala Leu Pro Leu Ser Ala 
    290                 295                 300                 


Pro Ser Gly Asn Ala Ser Gly Arg Pro Leu Ser Gln Leu Leu Asn Leu 
305                 310                 315                 320 


Asp Leu Ser Tyr Asn Glu Ile Glu Leu Ile Pro Asp Ser Phe Leu Glu 
                325                 330                 335     


His Leu Thr Ser Leu Cys Phe Leu Asn Leu Ser Arg Asn Cys Leu Arg 
            340                 345                 350         


Thr Phe Glu Ala Arg Arg Leu Gly Ser Leu Pro Cys Leu Met Leu Leu 
        355                 360                 365             


Asp Leu Ser His Asn Ala Leu Glu Thr Leu Glu Leu Gly Ala Arg Ala 
    370                 375                 380                 


Leu Gly Ser Leu Arg Thr Leu Leu Leu Gln Gly Asn Ala Leu Arg Asp 
385                 390                 395                 400 


Leu Pro Pro Tyr Thr Phe Ala Asn Leu Ala Ser Leu Gln Arg Leu Asn 
                405                 410                 415     


Leu Gln Gly Asn Arg Val Ser Pro Cys Gly Gly Pro Asp Glu Pro Gly 
            420                 425                 430         


Pro Ser Gly Cys Val Ala Phe Ser Gly Ile Thr Ser Leu Arg Ser Leu 
        435                 440                 445             


Ser Leu Val Asp Asn Glu Ile Glu Leu Leu Arg Ala Gly Ala Phe Leu 
    450                 455                 460                 


His Thr Pro Leu Thr Glu Leu Asp Leu Ser Ser Asn Pro Gly Leu Glu 
465                 470                 475                 480 


Val Ala Thr Gly Ala Leu Gly Gly Leu Glu Ala Ser Leu Glu Val Leu 
                485                 490                 495     


Ala Leu Gln Gly Asn Gly Leu Met Val Leu Gln Val Asp Leu Pro Cys 
            500                 505                 510         


Phe Ile Cys Leu Lys Arg Leu Asn Leu Ala Glu Asn Arg Leu Ser His 
        515                 520                 525             


Leu Pro Ala Trp Thr Gln Ala Val Ser Leu Glu Val Leu Asp Leu Arg 
    530                 535                 540                 


Asn Asn Ser Phe Ser Leu Leu Pro Gly Ser Ala Met Gly Gly Leu Glu 
545                 550                 555                 560 


Thr Ser Leu Arg Arg Leu Tyr Leu Gln Gly Asn Pro Leu Ser Cys Cys 
                565                 570                 575     


Gly Asn Gly Trp Leu Ala Ala Gln Leu His Gln Gly Arg Val Asp Val 
            580                 585                 590         


Asp Ala Thr Gln Asp Leu Ile Cys Arg Phe Ser Ser Gln Glu Glu Val 
        595                 600                 605             


Ser Leu Ser His Val Arg Pro Glu Asp Cys Glu Lys Gly Gly Leu Lys 
    610                 615                 620                 


Asn Ile Asn Leu Ile Ile Ile Leu Thr Phe Ile Leu Val Ser Ala Ile 
625                 630                 635                 640 


Leu Leu Thr Thr Leu Ala Ala Cys Cys Cys Val Arg Arg Gln Lys Phe 
                645                 650                 655     


Asn Gln Gln Tyr Lys Ala 
            660         


<210>  8028
<211>  662
<212>  PRT
<213>  Homo Sapiens

<400>  8028

Met Arg Pro Gln Ile Leu Leu Leu Leu Ala Leu Leu Thr Leu Gly Leu 
1               5                   10                  15      


Ala Ala Gln His Gln Asp Lys Val Pro Cys Lys Met Val Asp Lys Lys 
            20                  25                  30          


Val Ser Cys Gln Val Leu Gly Leu Leu Gln Val Pro Ser Val Leu Pro 
        35                  40                  45              


Pro Asp Thr Glu Thr Leu Asp Leu Ser Gly Asn Gln Leu Arg Ser Ile 
    50                  55                  60                  


Leu Ala Ser Pro Leu Gly Phe Tyr Thr Ala Leu Arg His Leu Asp Leu 
65                  70                  75                  80  


Ser Thr Asn Glu Ile Ser Phe Leu Gln Pro Gly Ala Phe Gln Ala Leu 
                85                  90                  95      


Thr His Leu Glu His Leu Ser Leu Ala His Asn Arg Leu Ala Met Ala 
            100                 105                 110         


Thr Ala Leu Ser Ala Gly Gly Leu Gly Pro Leu Pro Arg Val Thr Ser 
        115                 120                 125             


Leu Asp Leu Ser Gly Asn Ser Leu Tyr Ser Gly Leu Leu Glu Arg Leu 
    130                 135                 140                 


Leu Gly Glu Ala Pro Ser Leu His Thr Leu Ser Leu Ala Glu Asn Ser 
145                 150                 155                 160 


Leu Thr Arg Leu Thr Arg His Thr Phe Arg Asp Met Pro Ala Leu Glu 
                165                 170                 175     


Gln Leu Asp Leu His Ser Asn Val Leu Met Asp Ile Glu Asp Gly Ala 
            180                 185                 190         


Phe Glu Gly Leu Pro Arg Leu Thr His Leu Asn Leu Ser Arg Asn Ser 
        195                 200                 205             


Leu Thr Cys Ile Ser Asp Phe Ser Leu Gln Gln Leu Arg Val Leu Asp 
    210                 215                 220                 


Leu Ser Cys Asn Ser Ile Glu Ala Phe Gln Thr Ala Ser Gln Pro Gln 
225                 230                 235                 240 


Ala Glu Phe Gln Leu Thr Trp Leu Asp Leu Arg Glu Asn Lys Leu Leu 
                245                 250                 255     


His Phe Pro Asp Leu Ala Ala Leu Pro Arg Leu Ile Tyr Leu Asn Leu 
            260                 265                 270         


Ser Asn Asn Leu Ile Arg Leu Pro Thr Gly Pro Pro Gln Asp Ser Lys 
        275                 280                 285             


Gly Ile His Ala Pro Ser Glu Gly Trp Ser Ala Leu Pro Leu Ser Ala 
    290                 295                 300                 


Pro Ser Gly Asn Ala Ser Gly Arg Pro Leu Ser Gln Leu Leu Asn Leu 
305                 310                 315                 320 


Asp Leu Ser Tyr Asn Glu Ile Glu Leu Ile Pro Asp Ser Phe Leu Glu 
                325                 330                 335     


His Leu Thr Ser Leu Cys Phe Leu Asn Leu Ser Arg Asn Cys Leu Arg 
            340                 345                 350         


Thr Phe Glu Ala Arg Arg Leu Gly Ser Leu Pro Cys Leu Met Leu Leu 
        355                 360                 365             


Asp Leu Ser His Asn Ala Leu Glu Thr Leu Glu Leu Gly Ala Arg Ala 
    370                 375                 380                 


Leu Gly Ser Leu Arg Thr Leu Leu Leu Gln Gly Asn Ala Leu Arg Asp 
385                 390                 395                 400 


Leu Pro Pro Tyr Thr Phe Ala Asn Leu Ala Ser Leu Gln Arg Leu Asn 
                405                 410                 415     


Leu Gln Gly Asn Arg Val Ser Pro Cys Gly Gly Pro Asp Glu Pro Gly 
            420                 425                 430         


Pro Ser Gly Cys Val Ala Phe Ser Gly Ile Thr Ser Leu Arg Ser Leu 
        435                 440                 445             


Ser Leu Val Asp Asn Glu Ile Glu Leu Leu Arg Ala Gly Ala Phe Leu 
    450                 455                 460                 


His Thr Pro Leu Thr Glu Leu Asp Leu Ser Ser Asn Pro Gly Leu Glu 
465                 470                 475                 480 


Val Ala Thr Gly Ala Leu Gly Gly Leu Glu Ala Ser Leu Glu Val Leu 
                485                 490                 495     


Ala Leu Gln Gly Asn Gly Leu Met Val Leu Gln Val Asp Leu Pro Cys 
            500                 505                 510         


Phe Ile Cys Leu Lys Arg Leu Asn Leu Ala Glu Asn Arg Leu Ser His 
        515                 520                 525             


Leu Pro Ala Trp Thr Gln Ala Val Ser Leu Glu Val Leu Asp Leu Arg 
    530                 535                 540                 


Asn Asn Ser Phe Ser Leu Leu Pro Gly Ser Ala Met Gly Gly Leu Glu 
545                 550                 555                 560 


Thr Ser Leu Arg Arg Leu Tyr Leu Gln Gly Asn Pro Leu Ser Cys Cys 
                565                 570                 575     


Gly Asn Gly Trp Leu Ala Ala Gln Leu His Gln Gly Arg Val Asp Val 
            580                 585                 590         


Asp Ala Thr Gln Asp Leu Ile Cys Arg Phe Ser Ser Gln Glu Glu Val 
        595                 600                 605             


Ser Leu Ser His Val Arg Pro Glu Asp Cys Glu Lys Gly Gly Leu Lys 
    610                 615                 620                 


Asn Ile Asn Leu Ile Ile Ile Leu Thr Phe Ile Leu Val Ser Ala Ile 
625                 630                 635                 640 


Leu Leu Thr Thr Leu Ala Ala Cys Cys Cys Val Arg Arg Gln Lys Phe 
                645                 650                 655     


Asn Gln Gln Tyr Lys Ala 
            660         


<210>  8029
<211>  55
<212>  PRT
<213>  Homo Sapiens

<400>  8029

Met Asn Leu Val Asp Leu Trp Leu Thr Arg Ser Leu Ser Met Cys Leu 
1               5                   10                  15      


Leu Leu Gln Ser Phe Val Leu Met Ile Leu Cys Phe His Ser Ala Ser 
            20                  25                  30          


Met Cys Pro Lys Gly Cys Leu Cys Ser Ser Ser Gly Gly Leu Asn Val 
        35                  40                  45              


Thr Cys Ser Asn Ala Asn Leu 
    50                  55  


<210>  8030
<211>  163
<212>  PRT
<213>  Homo Sapiens

<400>  8030

Met Asn Leu Val Asp Leu Trp Leu Thr Arg Ser Leu Ser Met Cys Leu 
1               5                   10                  15      


Leu Leu Gln Ser Phe Val Leu Met Ile Leu Cys Phe His Ser Ala Ser 
            20                  25                  30          


Met Cys Pro Lys Gly Cys Leu Cys Ser Ser Ser Gly Gly Leu Asn Val 
        35                  40                  45              


Thr Cys Ser Asn Ala Asn Leu Lys Glu Ile Pro Arg Asp Leu Pro Pro 
    50                  55                  60                  


Glu Thr Val Leu Leu Tyr Leu Asp Ser Asn Gln Ile Thr Ser Ile Pro 
65                  70                  75                  80  


Asn Glu Ile Phe Lys Asp Leu His Gln Leu Arg Val Leu Asn Leu Ser 
                85                  90                  95      


Lys Asn Gly Ile Glu Phe Ile Asp Glu His Ala Phe Lys Gly Val Ala 
            100                 105                 110         


Glu Thr Leu Gln Thr Leu Asp Leu Ser Asp Asn Arg Ile Gln Ser Val 
        115                 120                 125             


His Lys Asn Ala Phe Asn Asn Leu Lys Ala Arg Ala Arg Ile Ala Asn 
    130                 135                 140                 


Asn Pro Trp His Cys Asp Cys Thr Leu Gln Gln Val Leu Arg Ser Met 
145                 150                 155                 160 


Ala Ser Asn 
            


<210>  8031
<211>  259
<212>  PRT
<213>  Homo Sapiens

<400>  8031

Met Asn Leu Val Asp Leu Trp Leu Thr Arg Ser Leu Ser Met Cys Leu 
1               5                   10                  15      


Leu Leu Gln Ser Phe Val Leu Met Ile Leu Cys Phe His Ser Ala Ser 
            20                  25                  30          


Met Cys Pro Lys Gly Cys Leu Cys Ser Ser Ser Gly Gly Leu Asn Val 
        35                  40                  45              


Thr Cys Ser Asn Ala Asn Leu Lys Glu Ile Pro Arg Asp Leu Pro Pro 
    50                  55                  60                  


Glu Thr Val Leu Leu Tyr Leu Asp Ser Asn Gln Ile Thr Ser Ile Pro 
65                  70                  75                  80  


Asn Glu Ile Phe Lys Asp Leu His Gln Leu Arg Val Leu Asn Leu Ser 
                85                  90                  95      


Lys Asn Gly Ile Glu Phe Ile Asp Glu His Ala Phe Lys Gly Val Ala 
            100                 105                 110         


Glu Thr Leu Gln Thr Leu Asp Leu Ser Asp Asn Arg Ile Gln Ser Val 
        115                 120                 125             


His Lys Asn Ala Phe Asn Asn Leu Lys Ala Arg Ala Arg Ile Ala Asn 
    130                 135                 140                 


Asn Pro Trp His Cys Asp Cys Thr Leu Gln Gln Val Leu Arg Ser Met 
145                 150                 155                 160 


Ala Ser Asn His Glu Thr Ala His Asn Val Ile Cys Lys Thr Ser Val 
                165                 170                 175     


Leu Asp Glu His Ala Gly Arg Pro Phe Leu Asn Ala Ala Asn Asp Ala 
            180                 185                 190         


Asp Leu Cys Asn Leu Pro Lys Lys Thr Thr Asp Tyr Ala Met Leu Val 
        195                 200                 205             


Thr Met Phe Gly Trp Phe Thr Met Val Ile Ser Tyr Val Val Tyr Tyr 
    210                 215                 220                 


Val Arg Gln Asn Gln Glu Asp Ala Arg Arg His Leu Glu Tyr Leu Lys 
225                 230                 235                 240 


Ser Leu Pro Ser Arg Gln Lys Lys Ala Asp Glu Pro Asp Asp Ile Ser 
                245                 250                 255     


Thr Val Val 
            


<210>  8032
<211>  259
<212>  PRT
<213>  Homo Sapiens

<400>  8032

Met Asn Leu Val Asp Leu Trp Leu Thr Arg Ser Leu Ser Met Cys Leu 
1               5                   10                  15      


Leu Leu Gln Ser Phe Val Leu Met Ile Leu Cys Phe His Ser Ala Ser 
            20                  25                  30          


Met Cys Pro Lys Gly Cys Leu Cys Ser Ser Ser Gly Gly Leu Asn Val 
        35                  40                  45              


Thr Cys Ser Asn Ala Asn Leu Lys Glu Ile Pro Arg Asp Leu Pro Pro 
    50                  55                  60                  


Glu Thr Val Leu Leu Tyr Leu Asp Ser Asn Gln Ile Thr Ser Ile Pro 
65                  70                  75                  80  


Asn Glu Ile Phe Lys Asp Leu His Gln Leu Arg Val Leu Asn Leu Ser 
                85                  90                  95      


Lys Asn Gly Ile Glu Phe Ile Asp Glu His Ala Phe Lys Gly Val Ala 
            100                 105                 110         


Glu Thr Leu Gln Thr Leu Asp Leu Ser Asp Asn Arg Ile Gln Ser Val 
        115                 120                 125             


His Lys Asn Ala Phe Asn Asn Leu Lys Ala Arg Ala Arg Ile Ala Asn 
    130                 135                 140                 


Asn Pro Trp His Cys Asp Cys Thr Leu Gln Gln Val Leu Arg Ser Met 
145                 150                 155                 160 


Ala Ser Asn His Glu Thr Ala His Asn Val Ile Cys Lys Thr Ser Val 
                165                 170                 175     


Leu Asp Glu His Ala Gly Arg Pro Phe Leu Asn Ala Ala Asn Asp Ala 
            180                 185                 190         


Asp Leu Cys Asn Leu Pro Lys Lys Thr Thr Asp Tyr Ala Met Leu Val 
        195                 200                 205             


Thr Met Phe Gly Trp Phe Thr Met Val Ile Ser Tyr Val Val Tyr Tyr 
    210                 215                 220                 


Val Arg Gln Asn Gln Glu Asp Ala Arg Arg His Leu Glu Tyr Leu Lys 
225                 230                 235                 240 


Ser Leu Pro Ser Arg Gln Lys Lys Ala Asp Glu Pro Asp Asp Ile Ser 
                245                 250                 255     


Thr Val Val 
            


<210>  8033
<211>  259
<212>  PRT
<213>  Homo Sapiens

<400>  8033

Met Asn Leu Val Asp Leu Trp Leu Thr Arg Ser Leu Ser Met Cys Leu 
1               5                   10                  15      


Leu Leu Gln Ser Phe Val Leu Met Ile Leu Cys Phe His Ser Ala Ser 
            20                  25                  30          


Met Cys Pro Lys Gly Cys Leu Cys Ser Ser Ser Gly Gly Leu Asn Val 
        35                  40                  45              


Thr Cys Ser Asn Ala Asn Leu Lys Glu Ile Pro Arg Asp Leu Pro Pro 
    50                  55                  60                  


Glu Thr Val Leu Leu Tyr Leu Asp Ser Asn Gln Ile Thr Ser Ile Pro 
65                  70                  75                  80  


Asn Glu Ile Phe Lys Asp Leu His Gln Leu Arg Val Leu Asn Leu Ser 
                85                  90                  95      


Lys Asn Gly Ile Glu Phe Ile Asp Glu His Ala Phe Lys Gly Val Ala 
            100                 105                 110         


Glu Thr Leu Gln Thr Leu Asp Leu Ser Asp Asn Arg Ile Gln Ser Val 
        115                 120                 125             


His Lys Asn Ala Phe Asn Asn Leu Lys Ala Arg Ala Arg Ile Ala Asn 
    130                 135                 140                 


Asn Pro Trp His Cys Asp Cys Thr Leu Gln Gln Val Leu Arg Ser Met 
145                 150                 155                 160 


Ala Ser Asn His Glu Thr Ala His Asn Val Ile Cys Lys Thr Ser Val 
                165                 170                 175     


Leu Asp Glu His Ala Gly Arg Pro Phe Leu Asn Ala Ala Asn Asp Ala 
            180                 185                 190         


Asp Leu Cys Asn Leu Pro Lys Lys Thr Thr Asp Tyr Ala Met Leu Val 
        195                 200                 205             


Thr Met Phe Gly Trp Phe Thr Met Val Ile Ser Tyr Val Val Tyr Tyr 
    210                 215                 220                 


Val Arg Gln Asn Gln Glu Asp Ala Arg Arg His Leu Glu Tyr Leu Lys 
225                 230                 235                 240 


Ser Leu Pro Ser Arg Gln Lys Lys Ala Asp Glu Pro Asp Asp Ile Ser 
                245                 250                 255     


Thr Val Val 
            


<210>  8034
<211>  238
<212>  PRT
<213>  Homo Sapiens

<400>  8034

Met Ala Arg Ala Arg Gly Ser Pro Cys Pro Pro Leu Pro Pro Gly Arg 
1               5                   10                  15      


Met Ser Trp Pro His Gly Ala Leu Leu Phe Leu Trp Leu Phe Ser Pro 
            20                  25                  30          


Pro Leu Gly Ala Gly Gly Gly Gly Val Ala Val Thr Ser Ala Ala Gly 
        35                  40                  45              


Gly Gly Ser Pro Pro Ala Thr Ser Cys Pro Val Ala Cys Ser Cys Ser 
    50                  55                  60                  


Asn Gln Ala Ser Arg Val Ile Cys Thr Arg Arg Asp Leu Ala Glu Val 
65                  70                  75                  80  


Pro Ala Ser Ile Pro Val Asn Thr Arg Tyr Leu Asn Leu Gln Glu Asn 
                85                  90                  95      


Gly Ile Gln Val Ile Arg Thr Asp Thr Phe Lys His Leu Arg His Leu 
            100                 105                 110         


Glu Ile Leu Gln Leu Ser Lys Asn Leu Val Arg Lys Ile Glu Val Gly 
        115                 120                 125             


Ala Phe Asn Gly Leu Pro Ser Leu Asn Thr Leu Glu Leu Phe Asp Asn 
    130                 135                 140                 


Arg Leu Thr Thr Val Pro Thr Gln Ala Phe Glu Tyr Leu Ser Lys Leu 
145                 150                 155                 160 


Arg Glu Leu Trp Leu Arg Asn Asn Pro Ile Glu Ser Ile Pro Ser Tyr 
                165                 170                 175     


Ala Phe Asn Arg Val Pro Ser Leu Arg Arg Leu Asp Leu Gly Glu Leu 
            180                 185                 190         


Lys Arg Leu Glu Tyr Ile Ser Glu Ala Ala Phe Glu Gly Leu Val Asn 
        195                 200                 205             


Leu Arg Tyr Leu Asn Leu Gly Met Cys Asn Leu Lys Asp Ile Pro Asn 
    210                 215                 220                 


Leu Thr Ala Leu Val Arg Leu Glu Glu Leu Glu Leu Ser Gly 
225                 230                 235             


<210>  8035
<211>  713
<212>  PRT
<213>  Homo Sapiens

<400>  8035

Met Ala Arg Ala Arg Gly Ser Pro Cys Pro Pro Leu Pro Pro Gly Arg 
1               5                   10                  15      


Met Ser Trp Pro His Gly Ala Leu Leu Phe Leu Trp Leu Phe Ser Pro 
            20                  25                  30          


Pro Leu Gly Ala Gly Gly Gly Gly Val Ala Val Thr Ser Ala Ala Gly 
        35                  40                  45              


Gly Gly Ser Pro Pro Ala Thr Ser Cys Pro Val Ala Cys Ser Cys Ser 
    50                  55                  60                  


Asn Gln Ala Ser Arg Val Ile Cys Thr Arg Arg Asp Leu Ala Glu Val 
65                  70                  75                  80  


Pro Ala Ser Ile Pro Val Asn Thr Arg Tyr Leu Asn Leu Gln Glu Asn 
                85                  90                  95      


Gly Ile Gln Val Ile Arg Thr Asp Thr Phe Lys His Leu Arg His Leu 
            100                 105                 110         


Glu Ile Leu Gln Leu Ser Lys Asn Leu Val Arg Lys Ile Glu Val Gly 
        115                 120                 125             


Ala Phe Asn Gly Leu Pro Ser Leu Asn Thr Leu Glu Leu Phe Asp Asn 
    130                 135                 140                 


Arg Leu Thr Thr Val Pro Thr Gln Ala Phe Glu Tyr Leu Ser Lys Leu 
145                 150                 155                 160 


Arg Glu Leu Trp Leu Arg Asn Asn Pro Ile Glu Ser Ile Pro Ser Tyr 
                165                 170                 175     


Ala Phe Asn Arg Val Pro Ser Leu Arg Arg Leu Asp Leu Gly Glu Leu 
            180                 185                 190         


Lys Arg Leu Glu Tyr Ile Ser Glu Ala Ala Phe Glu Gly Leu Val Asn 
        195                 200                 205             


Leu Arg Tyr Leu Asn Leu Gly Met Cys Asn Leu Lys Asp Ile Pro Asn 
    210                 215                 220                 


Leu Thr Ala Leu Val Arg Leu Glu Glu Leu Glu Leu Ser Gly Asn Arg 
225                 230                 235                 240 


Leu Asp Leu Ile Arg Pro Gly Ser Phe Gln Gly Leu Thr Ser Leu Arg 
                245                 250                 255     


Lys Leu Trp Leu Met His Ala Gln Val Ala Thr Ile Glu Arg Asn Ala 
            260                 265                 270         


Phe Asp Asp Leu Lys Ser Leu Glu Glu Leu Asn Leu Ser His Asn Asn 
        275                 280                 285             


Leu Met Ser Leu Pro His Asp Leu Phe Thr Pro Leu His Arg Leu Glu 
    290                 295                 300                 


Arg Val His Leu Asn His Asn Pro Trp His Cys Asn Cys Asp Val Leu 
305                 310                 315                 320 


Trp Leu Ser Trp Trp Leu Lys Glu Thr Val Pro Ser Asn Thr Thr Cys 
                325                 330                 335     


Cys Ala Arg Cys His Ala Pro Ala Gly Leu Lys Gly Arg Tyr Ile Gly 
            340                 345                 350         


Glu Leu Asp Gln Ser His Phe Thr Cys Tyr Ala Pro Val Ile Val Glu 
        355                 360                 365             


Pro Pro Thr Asp Leu Asn Val Thr Glu Gly Met Ala Ala Glu Leu Lys 
    370                 375                 380                 


Cys Arg Thr Gly Thr Ser Met Thr Ser Val Asn Trp Leu Thr Pro Asn 
385                 390                 395                 400 


Gly Thr Leu Met Thr His Gly Ser Tyr Arg Val Arg Ile Ser Val Leu 
                405                 410                 415     


His Asp Gly Thr Leu Asn Phe Thr Asn Val Thr Val Gln Asp Thr Gly 
            420                 425                 430         


Gln Tyr Thr Cys Met Val Thr Asn Ser Ala Gly Asn Thr Thr Ala Ser 
        435                 440                 445             


Ala Thr Leu Asn Val Ser Ala Val Asp Pro Val Ala Ala Gly Gly Thr 
    450                 455                 460                 


Gly Ser Gly Gly Gly Gly Pro Gly Gly Ser Gly Gly Val Gly Gly Gly 
465                 470                 475                 480 


Ser Gly Gly Tyr Thr Tyr Phe Thr Thr Val Thr Val Glu Thr Leu Glu 
                485                 490                 495     


Thr Gln Pro Gly Glu Glu Ala Leu Gln Pro Arg Gly Thr Glu Lys Glu 
            500                 505                 510         


Pro Pro Gly Pro Thr Thr Asp Gly Val Trp Gly Gly Gly Arg Pro Gly 
        515                 520                 525             


Asp Ala Ala Gly Pro Ala Ser Ser Ser Thr Thr Ala Pro Ala Pro Arg 
    530                 535                 540                 


Ser Ser Arg Pro Thr Glu Lys Ala Phe Thr Val Pro Ile Thr Asp Val 
545                 550                 555                 560 


Thr Glu Asn Ala Leu Lys Asp Leu Asp Asp Val Met Lys Thr Thr Lys 
                565                 570                 575     


Ile Ile Ile Gly Cys Phe Val Ala Ile Thr Phe Met Ala Ala Val Met 
            580                 585                 590         


Leu Val Ala Phe Tyr Lys Leu Arg Lys Gln His Gln Leu His Lys His 
        595                 600                 605             


His Gly Pro Thr Arg Thr Val Glu Ile Ile Asn Val Glu Asp Glu Leu 
    610                 615                 620                 


Pro Ala Ala Ser Ala Val Ser Val Ala Ala Ala Ala Ala Val Ala Ser 
625                 630                 635                 640 


Gly Gly Gly Val Gly Gly Asp Ser His Leu Ala Leu Pro Ala Leu Glu 
                645                 650                 655     


Arg Asp His Leu Asn His His His Tyr Val Ala Ala Ala Phe Lys Ala 
            660                 665                 670         


His Tyr Ser Ser Asn Pro Ser Gly Gly Gly Cys Gly Gly Lys Gly Pro 
        675                 680                 685             


Pro Gly Leu Asn Ser Ile His Glu Pro Leu Leu Phe Lys Ser Gly Ser 
    690                 695                 700                 


Lys Glu Asn Val Gln Glu Thr Gln Ile 
705                 710             


<210>  8036
<211>  713
<212>  PRT
<213>  Homo Sapiens

<400>  8036

Met Ala Arg Ala Arg Gly Ser Pro Cys Pro Pro Leu Pro Pro Gly Arg 
1               5                   10                  15      


Met Ser Trp Pro His Gly Ala Leu Leu Phe Leu Trp Leu Phe Ser Pro 
            20                  25                  30          


Pro Leu Gly Ala Gly Gly Gly Gly Val Ala Val Thr Ser Ala Ala Gly 
        35                  40                  45              


Gly Gly Ser Pro Pro Ala Thr Ser Cys Pro Val Ala Cys Ser Cys Ser 
    50                  55                  60                  


Asn Gln Ala Ser Arg Val Ile Cys Thr Arg Arg Asp Leu Ala Glu Val 
65                  70                  75                  80  


Pro Ala Ser Ile Pro Val Asn Thr Arg Tyr Leu Asn Leu Gln Glu Asn 
                85                  90                  95      


Gly Ile Gln Val Ile Arg Thr Asp Thr Phe Lys His Leu Arg His Leu 
            100                 105                 110         


Glu Ile Leu Gln Leu Ser Lys Asn Leu Val Arg Lys Ile Glu Val Gly 
        115                 120                 125             


Ala Phe Asn Gly Leu Pro Ser Leu Asn Thr Leu Glu Leu Phe Asp Asn 
    130                 135                 140                 


Arg Leu Thr Thr Val Pro Thr Gln Ala Phe Glu Tyr Leu Ser Lys Leu 
145                 150                 155                 160 


Arg Glu Leu Trp Leu Arg Asn Asn Pro Ile Glu Ser Ile Pro Ser Tyr 
                165                 170                 175     


Ala Phe Asn Arg Val Pro Ser Leu Arg Arg Leu Asp Leu Gly Glu Leu 
            180                 185                 190         


Lys Arg Leu Glu Tyr Ile Ser Glu Ala Ala Phe Glu Gly Leu Val Asn 
        195                 200                 205             


Leu Arg Tyr Leu Asn Leu Gly Met Cys Asn Leu Lys Asp Ile Pro Asn 
    210                 215                 220                 


Leu Thr Ala Leu Val Arg Leu Glu Glu Leu Glu Leu Ser Gly Asn Arg 
225                 230                 235                 240 


Leu Asp Leu Ile Arg Pro Gly Ser Phe Gln Gly Leu Thr Ser Leu Arg 
                245                 250                 255     


Lys Leu Trp Leu Met His Ala Gln Val Ala Thr Ile Glu Arg Asn Ala 
            260                 265                 270         


Phe Asp Asp Leu Lys Ser Leu Glu Glu Leu Asn Leu Ser His Asn Asn 
        275                 280                 285             


Leu Met Ser Leu Pro His Asp Leu Phe Thr Pro Leu His Arg Leu Glu 
    290                 295                 300                 


Arg Val His Leu Asn His Asn Pro Trp His Cys Asn Cys Asp Val Leu 
305                 310                 315                 320 


Trp Leu Ser Trp Trp Leu Lys Glu Thr Val Pro Ser Asn Thr Thr Cys 
                325                 330                 335     


Cys Ala Arg Cys His Ala Pro Ala Gly Leu Lys Gly Arg Tyr Ile Gly 
            340                 345                 350         


Glu Leu Asp Gln Ser His Phe Thr Cys Tyr Ala Pro Val Ile Val Glu 
        355                 360                 365             


Pro Pro Thr Asp Leu Asn Val Thr Glu Gly Met Ala Ala Glu Leu Lys 
    370                 375                 380                 


Cys Arg Thr Gly Thr Ser Met Thr Ser Val Asn Trp Leu Thr Pro Asn 
385                 390                 395                 400 


Gly Thr Leu Met Thr His Gly Ser Tyr Arg Val Arg Ile Ser Val Leu 
                405                 410                 415     


His Asp Gly Thr Leu Asn Phe Thr Asn Val Thr Val Gln Asp Thr Gly 
            420                 425                 430         


Gln Tyr Thr Cys Met Val Thr Asn Ser Ala Gly Asn Thr Thr Ala Ser 
        435                 440                 445             


Ala Thr Leu Asn Val Ser Ala Val Asp Pro Val Ala Ala Gly Gly Thr 
    450                 455                 460                 


Gly Ser Gly Gly Gly Gly Pro Gly Gly Ser Gly Gly Val Gly Gly Gly 
465                 470                 475                 480 


Ser Gly Gly Tyr Thr Tyr Phe Thr Thr Val Thr Val Glu Thr Leu Glu 
                485                 490                 495     


Thr Gln Pro Gly Glu Glu Ala Leu Gln Pro Arg Gly Thr Glu Lys Glu 
            500                 505                 510         


Pro Pro Gly Pro Thr Thr Asp Gly Val Trp Gly Gly Gly Arg Pro Gly 
        515                 520                 525             


Asp Ala Ala Gly Pro Ala Ser Ser Ser Thr Thr Ala Pro Ala Pro Arg 
    530                 535                 540                 


Ser Ser Arg Pro Thr Glu Lys Ala Phe Thr Val Pro Ile Thr Asp Val 
545                 550                 555                 560 


Thr Glu Asn Ala Leu Lys Asp Leu Asp Asp Val Met Lys Thr Thr Lys 
                565                 570                 575     


Ile Ile Ile Gly Cys Phe Val Ala Ile Thr Phe Met Ala Ala Val Met 
            580                 585                 590         


Leu Val Ala Phe Tyr Lys Leu Arg Lys Gln His Gln Leu His Lys His 
        595                 600                 605             


His Gly Pro Thr Arg Thr Val Glu Ile Ile Asn Val Glu Asp Glu Leu 
    610                 615                 620                 


Pro Ala Ala Ser Ala Val Ser Val Ala Ala Ala Ala Ala Val Ala Ser 
625                 630                 635                 640 


Gly Gly Gly Val Gly Gly Asp Ser His Leu Ala Leu Pro Ala Leu Glu 
                645                 650                 655     


Arg Asp His Leu Asn His His His Tyr Val Ala Ala Ala Phe Lys Ala 
            660                 665                 670         


His Tyr Ser Ser Asn Pro Ser Gly Gly Gly Cys Gly Gly Lys Gly Pro 
        675                 680                 685             


Pro Gly Leu Asn Ser Ile His Glu Pro Leu Leu Phe Lys Ser Gly Ser 
    690                 695                 700                 


Lys Glu Asn Val Gln Glu Thr Gln Ile 
705                 710             


<210>  8037
<211>  71
<212>  PRT
<213>  Homo Sapiens

<400>  8037

Met Cys Gly Leu Gln Phe Ser Leu Pro Cys Leu Arg Leu Phe Leu Val 
1               5                   10                  15      


Val Thr Cys Tyr Leu Leu Leu Leu Leu His Lys Glu Ile Leu Gly Cys 
            20                  25                  30          


Ser Ser Val Cys Gln Leu Cys Thr Gly Arg Gln Ile Asn Cys Arg Asn 
        35                  40                  45              


Leu Gly Leu Ser Ser Ile Pro Lys Asn Phe Pro Glu Ser Thr Val Phe 
    50                  55                  60                  


Leu Leu Ala Ser Lys Gly Pro 
65                  70      


<210>  8038
<211>  622
<212>  PRT
<213>  Homo Sapiens

<400>  8038

Met Cys Gly Leu Gln Phe Ser Leu Pro Cys Leu Arg Leu Phe Leu Val 
1               5                   10                  15      


Val Thr Cys Tyr Leu Leu Leu Leu Leu His Lys Glu Ile Leu Gly Cys 
            20                  25                  30          


Ser Ser Val Cys Gln Leu Cys Thr Gly Arg Gln Ile Asn Cys Arg Asn 
        35                  40                  45              


Leu Gly Leu Ser Ser Ile Pro Lys Asn Phe Pro Glu Ser Thr Val Phe 
    50                  55                  60                  


Leu Tyr Leu Thr Gly Asn Asn Ile Ser Tyr Ile Asn Glu Ser Glu Leu 
65                  70                  75                  80  


Thr Gly Leu His Ser Leu Val Ala Leu Tyr Leu Asp Asn Ser Asn Ile 
                85                  90                  95      


Leu Tyr Val Tyr Pro Lys Ala Phe Val Gln Leu Arg His Leu Tyr Phe 
            100                 105                 110         


Leu Phe Leu Asn Asn Asn Phe Ile Lys Arg Leu Asp Pro Gly Ile Phe 
        115                 120                 125             


Lys Gly Leu Leu Asn Leu Arg Asn Leu Tyr Leu Gln Tyr Asn Gln Val 
    130                 135                 140                 


Ser Phe Val Pro Arg Gly Val Phe Asn Asp Leu Val Ser Val Gln Tyr 
145                 150                 155                 160 


Leu Asn Leu Gln Arg Asn Arg Leu Thr Val Leu Gly Ser Gly Thr Phe 
                165                 170                 175     


Val Gly Met Val Ala Leu Arg Ile Leu Asp Leu Ser Asn Asn Asn Ile 
            180                 185                 190         


Leu Arg Ile Ser Glu Ser Gly Phe Gln His Leu Glu Asn Leu Ala Cys 
        195                 200                 205             


Leu Tyr Leu Gly Ser Asn Asn Leu Thr Lys Val Pro Ser Asn Ala Phe 
    210                 215                 220                 


Glu Val Leu Lys Ser Leu Arg Arg Leu Ser Leu Ser His Asn Pro Ile 
225                 230                 235                 240 


Glu Ala Ile Gln Pro Phe Ala Phe Lys Gly Leu Ala Asn Leu Glu Tyr 
                245                 250                 255     


Leu Leu Leu Lys Asn Ser Arg Ile Arg Asn Val Thr Arg Asp Gly Phe 
            260                 265                 270         


Ser Gly Ile Asn Asn Leu Lys His Leu Ile Leu Ser His Asn Asp Leu 
        275                 280                 285             


Glu Asn Leu Asn Ser Asp Thr Phe Ser Leu Leu Lys Asn Leu Ile Tyr 
    290                 295                 300                 


Leu Lys Leu Asp Arg Asn Arg Ile Ile Ser Ile Asp Asn Asp Thr Phe 
305                 310                 315                 320 


Glu Asn Met Gly Ala Ser Leu Lys Ile Leu Asn Leu Ser Phe Asn Asn 
                325                 330                 335     


Leu Thr Ala Leu His Pro Arg Val Leu Lys Pro Leu Ser Ser Leu Ile 
            340                 345                 350         


His Leu Gln Ala Asn Ser Asn Pro Trp Glu Cys Asn Cys Lys Leu Leu 
        355                 360                 365             


Gly Leu Arg Asp Trp Leu Ala Ser Ser Ala Ile Thr Leu Asn Ile Tyr 
    370                 375                 380                 


Cys Gln Asn Pro Pro Ser Met Arg Gly Arg Ala Leu Arg Tyr Ile Asn 
385                 390                 395                 400 


Ile Thr Asn Cys Val Thr Ser Ser Ile Asn Val Ser Arg Ala Trp Ala 
                405                 410                 415     


Val Val Lys Ser Pro His Ile His His Lys Thr Thr Ala Leu Met Met 
            420                 425                 430         


Ala Trp His Lys Val Thr Thr Asn Gly Ser Pro Leu Glu Asn Thr Glu 
        435                 440                 445             


Thr Glu Asn Ile Thr Phe Trp Glu Arg Ile Pro Thr Ser Pro Ala Gly 
    450                 455                 460                 


Arg Phe Phe Gln Glu Asn Ala Phe Gly Asn Pro Leu Glu Thr Thr Ala 
465                 470                 475                 480 


Val Leu Pro Val Gln Ile Gln Leu Thr Thr Ser Val Thr Leu Asn Leu 
                485                 490                 495     


Glu Lys Asn Ser Ala Leu Pro Asn Asp Ala Ala Ser Met Ser Gly Lys 
            500                 505                 510         


Thr Ser Leu Ile Cys Thr Gln Glu Val Glu Lys Leu Asn Glu Ala Phe 
        515                 520                 525             


Asp Ile Leu Leu Ala Phe Phe Ile Leu Ala Cys Val Leu Ile Ile Phe 
    530                 535                 540                 


Leu Ile Tyr Lys Val Val Gln Phe Lys Gln Lys Leu Lys Ala Ser Glu 
545                 550                 555                 560 


Asn Ser Arg Glu Asn Arg Leu Glu Tyr Tyr Ser Phe Tyr Gln Ser Ala 
                565                 570                 575     


Arg Tyr Asn Val Thr Ala Ser Ile Cys Asn Thr Ser Pro Asn Ser Leu 
            580                 585                 590         


Glu Ser Pro Gly Leu Glu Gln Ile Arg Leu His Lys Gln Ile Val Pro 
        595                 600                 605             


Glu Asn Glu Ala Gln Val Ile Leu Phe Glu His Ser Ala Leu 
    610                 615                 620         


<210>  8039
<211>  708
<212>  PRT
<213>  Homo Sapiens

<400>  8039

Met Lys Asp Met Pro Leu Arg Ile His Val Leu Leu Gly Leu Ala Ile 
1               5                   10                  15      


Thr Thr Leu Val Gln Ala Val Asp Lys Lys Val Asp Cys Pro Arg Leu 
            20                  25                  30          


Cys Thr Cys Glu Ile Arg Pro Trp Phe Thr Pro Arg Ser Ile Tyr Met 
        35                  40                  45              


Glu Ala Ser Thr Val Asp Cys Asn Asp Leu Gly Leu Leu Thr Phe Pro 
    50                  55                  60                  


Ala Arg Leu Pro Ala Asn Thr Gln Ile Leu Leu Leu Gln Thr Asn Asn 
65                  70                  75                  80  


Ile Ala Lys Ile Glu Tyr Ser Thr Asp Phe Pro Val Asn Leu Thr Gly 
                85                  90                  95      


Leu Asp Leu Ser Gln Asn Asn Leu Ser Ser Val Thr Asn Ile Asn Val 
            100                 105                 110         


Lys Lys Met Pro Gln Leu Leu Ser Val Tyr Leu Glu Glu Asn Lys Leu 
        115                 120                 125             


Thr Glu Leu Pro Glu Lys Cys Leu Ser Glu Leu Ser Asn Leu Gln Glu 
    130                 135                 140                 


Leu Tyr Ile Asn His Asn Leu Leu Ser Thr Ile Ser Pro Gly Ala Phe 
145                 150                 155                 160 


Ile Gly Leu His Asn Leu Leu Arg Leu His Leu Asn Ser Asn Arg Leu 
                165                 170                 175     


Gln Met Ile Asn Ser Lys Trp Phe Asp Ala Leu Pro Asn Leu Glu Ile 
            180                 185                 190         


Leu Met Ile Gly Glu Asn Pro Ile Ile Arg Ile Lys Asp Met Asn Phe 
        195                 200                 205             


Lys Pro Leu Ile Asn Leu Arg Ser Leu Val Ile Ala Gly Ile Asn Leu 
    210                 215                 220                 


Thr Glu Ile Pro Asp Asn Ala Leu Val Gly Leu Glu Asn Leu Glu Ser 
225                 230                 235                 240 


Ile Ser Phe Tyr Asp Asn Arg Leu Ile Lys Val Pro His Val Ala Leu 
                245                 250                 255     


Gln Lys Val Val Asn Leu Lys Phe Leu Asp Leu Asn Lys Asn Pro Ile 
            260                 265                 270         


Asn Arg Ile Arg Arg Gly Asp Phe Ser Asn Met Leu His Leu Lys Glu 
        275                 280                 285             


Leu Gly Ile Asn Asn Met Pro Glu Leu Ile Ser Ile Asp Ser Leu Ala 
    290                 295                 300                 


Val Asp Asn Leu Pro Asp Leu Arg Lys Ile Glu Ala Thr Asn Asn Pro 
305                 310                 315                 320 


Arg Leu Ser Tyr Ile His Pro Asn Ala Phe Phe Arg Leu Pro Lys Leu 
                325                 330                 335     


Glu Ser Leu Met Leu Asn Ser Asn Ala Leu Ser Ala Leu Tyr His Gly 
            340                 345                 350         


Thr Ile Glu Ser Leu Pro Asn Leu Lys Glu Ile Ser Ile His Ser Asn 
        355                 360                 365             


Pro Ile Arg Cys Asp Cys Val Ile Arg Trp Met Asn Met Asn Lys Thr 
    370                 375                 380                 


Asn Ile Arg Phe Met Glu Pro Asp Ser Leu Phe Cys Val Asp Pro Pro 
385                 390                 395                 400 


Glu Phe Gln Gly Gln Asn Val Arg Gln Val His Phe Arg Asp Met Met 
                405                 410                 415     


Glu Ile Cys Leu Pro Leu Ile Ala Pro Glu Ser Phe Pro Ser Asn Leu 
            420                 425                 430         


Asn Val Glu Ala Gly Ser Tyr Val Ser Phe His Cys Arg Ala Thr Ala 
        435                 440                 445             


Glu Pro Gln Pro Glu Ile Tyr Trp Ile Thr Pro Ser Gly Gln Lys Leu 
    450                 455                 460                 


Leu Pro Asn Thr Leu Thr Asp Lys Phe Tyr Val His Ser Glu Gly Thr 
465                 470                 475                 480 


Leu Asp Ile Asn Gly Val Thr Pro Lys Glu Gly Gly Leu Tyr Thr Cys 
                485                 490                 495     


Ile Ala Thr Asn Leu Val Gly Ala Asp Leu Lys Ser Val Met Ile Lys 
            500                 505                 510         


Val Asp Gly Ser Phe Pro Gln Asp Asn Asn Gly Ser Leu Asn Ile Lys 
        515                 520                 525             


Ile Arg Asp Ile Gln Ala Asn Ser Val Leu Val Ser Trp Lys Ala Ser 
    530                 535                 540                 


Ser Lys Ile Leu Lys Ser Ser Val Lys Trp Thr Ala Phe Val Lys Thr 
545                 550                 555                 560 


Glu Asn Ser His Ala Ala Gln Ser Ala Arg Ile Pro Ser Asp Val Lys 
                565                 570                 575     


Val Tyr Asn Leu Thr His Leu Asn Pro Ser Thr Glu Tyr Lys Ile Cys 
            580                 585                 590         


Ile Asp Ile Pro Thr Ile Tyr Gln Lys Asn Arg Lys Lys Cys Val Asn 
        595                 600                 605             


Val Thr Thr Lys Gly Leu His Pro Asp Gln Lys Glu Tyr Glu Lys Asn 
    610                 615                 620                 


Asn Thr Thr Thr Leu Met Ala Cys Leu Gly Gly Leu Leu Gly Ile Ile 
625                 630                 635                 640 


Gly Val Ile Cys Leu Ile Ser Cys Leu Ser Pro Glu Met Asn Cys Asp 
                645                 650                 655     


Gly Gly His Ser Tyr Val Arg Asn Tyr Leu Gln Lys Pro Thr Phe Ala 
            660                 665                 670         


Leu Gly Glu Leu Tyr Pro Pro Leu Ile Asn Leu Trp Glu Ala Gly Lys 
        675                 680                 685             


Glu Lys Ser Thr Ser Leu Lys Val Lys Ala Thr Val Ile Gly Leu Pro 
    690                 695                 700                 


Thr Asn Met Ser 
705             


<210>  8040
<211>  708
<212>  PRT
<213>  Homo Sapiens

<400>  8040

Met Lys Asp Met Pro Leu Arg Ile His Val Leu Leu Gly Leu Ala Ile 
1               5                   10                  15      


Thr Thr Leu Val Gln Ala Val Asp Lys Lys Val Asp Cys Pro Arg Leu 
            20                  25                  30          


Cys Thr Cys Glu Ile Arg Pro Trp Phe Thr Pro Arg Ser Ile Tyr Met 
        35                  40                  45              


Glu Ala Ser Thr Val Asp Cys Asn Asp Leu Gly Leu Leu Thr Phe Pro 
    50                  55                  60                  


Ala Arg Leu Pro Ala Asn Thr Gln Ile Leu Leu Leu Gln Thr Asn Asn 
65                  70                  75                  80  


Ile Ala Lys Ile Glu Tyr Ser Thr Asp Phe Pro Val Asn Leu Thr Gly 
                85                  90                  95      


Leu Asp Leu Ser Gln Asn Asn Leu Ser Ser Val Thr Asn Ile Asn Val 
            100                 105                 110         


Lys Lys Met Pro Gln Leu Leu Ser Val Tyr Leu Glu Glu Asn Lys Leu 
        115                 120                 125             


Thr Glu Leu Pro Glu Lys Cys Leu Ser Glu Leu Ser Asn Leu Gln Glu 
    130                 135                 140                 


Leu Tyr Ile Asn His Asn Leu Leu Ser Thr Ile Ser Pro Gly Ala Phe 
145                 150                 155                 160 


Ile Gly Leu His Asn Leu Leu Arg Leu His Leu Asn Ser Asn Arg Leu 
                165                 170                 175     


Gln Met Ile Asn Ser Lys Trp Phe Asp Ala Leu Pro Asn Leu Glu Ile 
            180                 185                 190         


Leu Met Ile Gly Glu Asn Pro Ile Ile Arg Ile Lys Asp Met Asn Phe 
        195                 200                 205             


Lys Pro Leu Ile Asn Leu Arg Ser Leu Val Ile Ala Gly Ile Asn Leu 
    210                 215                 220                 


Thr Glu Ile Pro Asp Asn Ala Leu Val Gly Leu Glu Asn Leu Glu Ser 
225                 230                 235                 240 


Ile Ser Phe Tyr Asp Asn Arg Leu Ile Lys Val Pro His Val Ala Leu 
                245                 250                 255     


Gln Lys Val Val Asn Leu Lys Phe Leu Asp Leu Asn Lys Asn Pro Ile 
            260                 265                 270         


Asn Arg Ile Arg Arg Gly Asp Phe Ser Asn Met Leu His Leu Lys Glu 
        275                 280                 285             


Leu Gly Ile Asn Asn Met Pro Glu Leu Ile Ser Ile Asp Ser Leu Ala 
    290                 295                 300                 


Val Asp Asn Leu Pro Asp Leu Arg Lys Ile Glu Ala Thr Asn Asn Pro 
305                 310                 315                 320 


Arg Leu Ser Tyr Ile His Pro Asn Ala Phe Phe Arg Leu Pro Lys Leu 
                325                 330                 335     


Glu Ser Leu Met Leu Asn Ser Asn Ala Leu Ser Ala Leu Tyr His Gly 
            340                 345                 350         


Thr Ile Glu Ser Leu Pro Asn Leu Lys Glu Ile Ser Ile His Ser Asn 
        355                 360                 365             


Pro Ile Arg Cys Asp Cys Val Ile Arg Trp Met Asn Met Asn Lys Thr 
    370                 375                 380                 


Asn Ile Arg Phe Met Glu Pro Asp Ser Leu Phe Cys Val Asp Pro Pro 
385                 390                 395                 400 


Glu Phe Gln Gly Gln Asn Val Arg Gln Val His Phe Arg Asp Met Met 
                405                 410                 415     


Glu Ile Cys Leu Pro Leu Ile Ala Pro Glu Ser Phe Pro Ser Asn Leu 
            420                 425                 430         


Asn Val Glu Ala Gly Ser Tyr Val Ser Phe His Cys Arg Ala Thr Ala 
        435                 440                 445             


Glu Pro Gln Pro Glu Ile Tyr Trp Ile Thr Pro Ser Gly Gln Lys Leu 
    450                 455                 460                 


Leu Pro Asn Thr Leu Thr Asp Lys Phe Tyr Val His Ser Glu Gly Thr 
465                 470                 475                 480 


Leu Asp Ile Asn Gly Val Thr Pro Lys Glu Gly Gly Leu Tyr Thr Cys 
                485                 490                 495     


Ile Ala Thr Asn Leu Val Gly Ala Asp Leu Lys Ser Val Met Ile Lys 
            500                 505                 510         


Val Asp Gly Ser Phe Pro Gln Asp Asn Asn Gly Ser Leu Asn Ile Lys 
        515                 520                 525             


Ile Arg Asp Ile Gln Ala Asn Ser Val Leu Val Ser Trp Lys Ala Ser 
    530                 535                 540                 


Ser Lys Ile Leu Lys Ser Ser Val Lys Trp Thr Ala Phe Val Lys Thr 
545                 550                 555                 560 


Glu Asn Ser His Ala Ala Gln Ser Ala Arg Ile Pro Ser Asp Val Lys 
                565                 570                 575     


Val Tyr Asn Leu Thr His Leu Asn Pro Ser Thr Glu Tyr Lys Ile Cys 
            580                 585                 590         


Ile Asp Ile Pro Thr Ile Tyr Gln Lys Asn Arg Lys Lys Cys Val Asn 
        595                 600                 605             


Val Thr Thr Lys Gly Leu His Pro Asp Gln Lys Glu Tyr Glu Lys Asn 
    610                 615                 620                 


Asn Thr Thr Thr Leu Met Ala Cys Leu Gly Gly Leu Leu Gly Ile Ile 
625                 630                 635                 640 


Gly Val Ile Cys Leu Ile Ser Cys Leu Ser Pro Glu Met Asn Cys Asp 
                645                 650                 655     


Gly Gly His Ser Tyr Val Arg Asn Tyr Leu Gln Lys Pro Thr Phe Ala 
            660                 665                 670         


Leu Gly Glu Leu Tyr Pro Pro Leu Ile Asn Leu Trp Glu Ala Gly Lys 
        675                 680                 685             


Glu Lys Ser Thr Ser Leu Lys Val Lys Ala Thr Val Ile Gly Leu Pro 
    690                 695                 700                 


Thr Asn Met Ser 
705             


<210>  8041
<211>  273
<212>  PRT
<213>  Homo Sapiens

<400>  8041

Met Lys Asp Met Pro Leu Arg Ile His Val Leu Leu Gly Leu Ala Ile 
1               5                   10                  15      


Thr Thr Leu Val Gln Ala Val Asp Lys Lys Val Asp Cys Pro Arg Leu 
            20                  25                  30          


Cys Thr Cys Glu Ile Arg Pro Trp Phe Thr Pro Arg Ser Ile Tyr Met 
        35                  40                  45              


Glu Ala Ser Thr Val Asp Cys Asn Asp Leu Gly Leu Leu Thr Phe Pro 
    50                  55                  60                  


Ala Arg Leu Pro Ala Asn Thr Gln Ile Leu Leu Leu Gln Thr Asn Asn 
65                  70                  75                  80  


Ile Ala Lys Ile Glu Tyr Ser Thr Asp Phe Pro Val Asn Leu Thr Gly 
                85                  90                  95      


Leu Asp Leu Ser Gln Asn Asn Leu Ser Ser Val Thr Asn Ile Asn Val 
            100                 105                 110         


Lys Lys Met Pro Gln Leu Leu Ser Val Tyr Leu Glu Glu Asn Lys Leu 
        115                 120                 125             


Thr Glu Leu Pro Glu Lys Cys Leu Ser Glu Leu Ser Asn Leu Gln Glu 
    130                 135                 140                 


Leu Tyr Ile Asn His Asn Leu Leu Ser Thr Ile Ser Pro Gly Ala Phe 
145                 150                 155                 160 


Ile Gly Leu His Asn Leu Leu Arg Leu His Leu Asn Ser Asn Arg Leu 
                165                 170                 175     


Gln Met Ile Asn Ser Lys Trp Phe Asp Ala Leu Pro Asn Leu Glu Ile 
            180                 185                 190         


Leu Met Ile Gly Glu Asn Pro Ile Ile Arg Ile Lys Asp Met Asn Phe 
        195                 200                 205             


Lys Pro Leu Ile Asn Leu Arg Ser Leu Val Ile Ala Gly Ile Asn Leu 
    210                 215                 220                 


Thr Glu Ile Pro Asp Asn Ala Leu Val Gly Leu Glu Asn Leu Glu Ser 
225                 230                 235                 240 


Ile Ser Phe Tyr Asp Asn Arg Leu Ile Lys Val Pro His Val Ala Leu 
                245                 250                 255     


Gln Lys Val Val Asn Leu Lys Phe Leu Asp Leu Asn Lys Asn Pro Ile 
            260                 265                 270         


Asn 
    


<210>  8042
<211>  708
<212>  PRT
<213>  Homo Sapiens

<400>  8042

Met Lys Asp Met Pro Leu Arg Ile His Val Leu Leu Gly Leu Ala Ile 
1               5                   10                  15      


Thr Thr Leu Val Gln Ala Val Asp Lys Lys Val Asp Cys Pro Arg Leu 
            20                  25                  30          


Cys Thr Cys Glu Ile Arg Pro Trp Phe Thr Pro Arg Ser Ile Tyr Met 
        35                  40                  45              


Glu Ala Ser Thr Val Asp Cys Asn Asp Leu Gly Leu Leu Thr Phe Pro 
    50                  55                  60                  


Ala Arg Leu Pro Ala Asn Thr Gln Ile Leu Leu Leu Gln Thr Asn Asn 
65                  70                  75                  80  


Ile Ala Lys Ile Glu Tyr Ser Thr Asp Phe Pro Val Asn Leu Thr Gly 
                85                  90                  95      


Leu Asp Leu Ser Gln Asn Asn Leu Ser Ser Val Thr Asn Ile Asn Val 
            100                 105                 110         


Lys Lys Met Pro Gln Leu Leu Ser Val Tyr Leu Glu Glu Asn Lys Leu 
        115                 120                 125             


Thr Glu Leu Pro Glu Lys Cys Leu Ser Glu Leu Ser Asn Leu Gln Glu 
    130                 135                 140                 


Leu Tyr Ile Asn His Asn Leu Leu Ser Thr Ile Ser Pro Gly Ala Phe 
145                 150                 155                 160 


Ile Gly Leu His Asn Leu Leu Arg Leu His Leu Asn Ser Asn Arg Leu 
                165                 170                 175     


Gln Met Ile Asn Ser Lys Trp Phe Asp Ala Leu Pro Asn Leu Glu Ile 
            180                 185                 190         


Leu Met Ile Gly Glu Asn Pro Ile Ile Arg Ile Lys Asp Met Asn Phe 
        195                 200                 205             


Lys Pro Leu Ile Asn Leu Arg Ser Leu Val Ile Ala Gly Ile Asn Leu 
    210                 215                 220                 


Thr Glu Ile Pro Asp Asn Ala Leu Val Gly Leu Glu Asn Leu Glu Ser 
225                 230                 235                 240 


Ile Ser Phe Tyr Asp Asn Arg Leu Ile Lys Val Pro His Val Ala Leu 
                245                 250                 255     


Gln Lys Val Val Asn Leu Lys Phe Leu Asp Leu Asn Lys Asn Pro Ile 
            260                 265                 270         


Asn Arg Ile Arg Arg Gly Asp Phe Ser Asn Met Leu His Leu Lys Glu 
        275                 280                 285             


Leu Gly Ile Asn Asn Met Pro Glu Leu Ile Ser Ile Asp Ser Leu Ala 
    290                 295                 300                 


Val Asp Asn Leu Pro Asp Leu Arg Lys Ile Glu Ala Thr Asn Asn Pro 
305                 310                 315                 320 


Arg Leu Ser Tyr Ile His Pro Asn Ala Phe Phe Arg Leu Pro Lys Leu 
                325                 330                 335     


Glu Ser Leu Met Leu Asn Ser Asn Ala Leu Ser Ala Leu Tyr His Gly 
            340                 345                 350         


Thr Ile Glu Ser Leu Pro Asn Leu Lys Glu Ile Ser Ile His Ser Asn 
        355                 360                 365             


Pro Ile Arg Cys Asp Cys Val Ile Arg Trp Met Asn Met Asn Lys Thr 
    370                 375                 380                 


Asn Ile Arg Phe Met Glu Pro Asp Ser Leu Phe Cys Val Asp Pro Pro 
385                 390                 395                 400 


Glu Phe Gln Gly Gln Asn Val Arg Gln Val His Phe Arg Asp Met Met 
                405                 410                 415     


Glu Ile Cys Leu Pro Leu Ile Ala Pro Glu Ser Phe Pro Ser Asn Leu 
            420                 425                 430         


Asn Val Glu Ala Gly Ser Tyr Val Ser Phe His Cys Arg Ala Thr Ala 
        435                 440                 445             


Glu Pro Gln Pro Glu Ile Tyr Trp Ile Thr Pro Ser Gly Gln Lys Leu 
    450                 455                 460                 


Leu Pro Asn Thr Leu Thr Asp Lys Phe Tyr Val His Ser Glu Gly Thr 
465                 470                 475                 480 


Leu Asp Ile Asn Gly Val Thr Pro Lys Glu Gly Gly Leu Tyr Thr Cys 
                485                 490                 495     


Ile Ala Thr Asn Leu Val Gly Ala Asp Leu Lys Ser Val Met Ile Lys 
            500                 505                 510         


Val Asp Gly Ser Phe Pro Gln Asp Asn Asn Gly Ser Leu Asn Ile Lys 
        515                 520                 525             


Ile Arg Asp Ile Gln Ala Asn Ser Val Leu Val Ser Trp Lys Ala Ser 
    530                 535                 540                 


Ser Lys Ile Leu Lys Ser Ser Val Lys Trp Thr Ala Phe Val Lys Thr 
545                 550                 555                 560 


Glu Asn Ser His Ala Ala Gln Ser Ala Arg Ile Pro Ser Asp Val Lys 
                565                 570                 575     


Val Tyr Asn Leu Thr His Leu Asn Pro Ser Thr Glu Tyr Lys Ile Cys 
            580                 585                 590         


Ile Asp Ile Pro Thr Ile Tyr Gln Lys Asn Arg Lys Lys Cys Val Asn 
        595                 600                 605             


Val Thr Thr Lys Gly Leu His Pro Asp Gln Lys Glu Tyr Glu Lys Asn 
    610                 615                 620                 


Asn Thr Thr Thr Leu Met Ala Cys Leu Gly Gly Leu Leu Gly Ile Ile 
625                 630                 635                 640 


Gly Val Ile Cys Leu Ile Ser Cys Leu Ser Pro Glu Met Asn Cys Asp 
                645                 650                 655     


Gly Gly His Ser Tyr Val Arg Asn Tyr Leu Gln Lys Pro Thr Phe Ala 
            660                 665                 670         


Leu Gly Glu Leu Tyr Pro Pro Leu Ile Asn Leu Trp Glu Ala Gly Lys 
        675                 680                 685             


Glu Lys Ser Thr Ser Leu Lys Val Lys Ala Thr Val Ile Gly Leu Pro 
    690                 695                 700                 


Thr Asn Met Ser 
705             


<210>  8043
<211>  109
<212>  PRT
<213>  Homo Sapiens

<400>  8043

Met Asp Phe Leu Leu Leu Gly Leu Cys Leu Tyr Trp Leu Leu Arg Arg 
1               5                   10                  15      


Pro Ser Gly Val Val Leu Cys Leu Leu Gly Ala Cys Phe Gln Met Leu 
            20                  25                  30          


Pro Ala Ala Pro Ser Gly Cys Pro Gln Leu Cys Arg Cys Glu Gly Arg 
        35                  40                  45              


Leu Leu Tyr Cys Glu Ala Leu Asn Leu Thr Glu Ala Pro His Asn Leu 
    50                  55                  60                  


Ser Gly Leu Leu Gly Leu Ser Leu Arg Tyr Asn Ser Leu Ser Glu Leu 
65                  70                  75                  80  


Arg Ala Gly Gln Phe Thr Gly Leu Met Gln Leu Thr Trp Leu Tyr Leu 
                85                  90                  95      


Asp His Asn His Ile Cys Ser Val Gln Gly Asp Ala Phe 
            100                 105                 


<210>  8044
<211>  183
<212>  PRT
<213>  Homo Sapiens

<400>  8044

Met Asp Phe Leu Leu Leu Gly Leu Cys Leu Tyr Trp Leu Leu Arg Arg 
1               5                   10                  15      


Pro Ser Gly Val Val Leu Cys Leu Leu Gly Ala Cys Phe Gln Met Leu 
            20                  25                  30          


Pro Ala Ala Pro Ser Gly Cys Pro Gln Leu Cys Arg Cys Glu Gly Arg 
        35                  40                  45              


Leu Leu Tyr Cys Glu Ala Leu Asn Leu Thr Glu Ala Pro His Asn Leu 
    50                  55                  60                  


Ser Gly Leu Leu Gly Leu Ser Leu Arg Tyr Asn Ser Leu Ser Glu Leu 
65                  70                  75                  80  


Arg Ala Gly Gln Phe Thr Gly Leu Met Gln Leu Thr Trp Leu Tyr Leu 
                85                  90                  95      


Asp His Asn His Ile Cys Ser Val Gln Gly Asp Ala Phe Gln Lys Leu 
            100                 105                 110         


Arg Arg Val Lys Glu Leu Thr Leu Ser Ser Asn Gln Ile Thr Gln Leu 
        115                 120                 125             


Pro Asn Thr Thr Phe Arg Pro Met Pro Asn Leu Arg Ser Val Asp Leu 
    130                 135                 140                 


Ser Tyr Asn Lys Leu Gln Ala Leu Ala Pro Asp Leu Phe His Gly Leu 
145                 150                 155                 160 


Arg Lys Leu Thr Thr Leu His Met Arg Ala Asn Ala Ile Gln Phe Val 
                165                 170                 175     


Pro Val Arg Ile Phe Gln Asp 
            180             


<210>  8045
<211>  223
<212>  PRT
<213>  Homo Sapiens

<400>  8045

Met Asp Phe Leu Leu Leu Gly Leu Cys Leu Tyr Trp Leu Leu Arg Arg 
1               5                   10                  15      


Pro Ser Gly Val Val Leu Cys Leu Leu Gly Ala Cys Phe Gln Met Leu 
            20                  25                  30          


Pro Ala Ala Pro Ser Gly Cys Pro Gln Leu Cys Arg Cys Glu Gly Arg 
        35                  40                  45              


Leu Leu Tyr Cys Glu Ala Leu Asn Leu Thr Glu Ala Pro His Asn Leu 
    50                  55                  60                  


Ser Gly Leu Leu Gly Leu Ser Leu Arg Tyr Asn Ser Leu Ser Glu Leu 
65                  70                  75                  80  


Arg Ala Gly Gln Phe Thr Gly Leu Met Gln Leu Thr Trp Leu Tyr Leu 
                85                  90                  95      


Asp His Asn His Ile Cys Ser Val Gln Gly Asp Ala Phe Gln Lys Leu 
            100                 105                 110         


Arg Arg Val Lys Glu Leu Thr Leu Ser Ser Asn Gln Ile Thr Gln Leu 
        115                 120                 125             


Pro Asn Thr Thr Phe Arg Pro Met Pro Asn Leu Arg Ser Val Asp Leu 
    130                 135                 140                 


Ser Tyr Asn Lys Leu Gln Ala Leu Ala Pro Asp Leu Phe His Gly Leu 
145                 150                 155                 160 


Arg Lys Leu Thr Thr Leu His Met Arg Ala Asn Ala Ile Gln Phe Val 
                165                 170                 175     


Pro Val Arg Ile Phe Gln Asp Cys Arg Ser Leu Lys Phe Leu Asp Ile 
            180                 185                 190         


Gly Tyr Asn Gln Leu Lys Ser Leu Ala Arg Asn Ser Phe Ala Gly Leu 
        195                 200                 205             


Phe Lys Leu Thr Glu Leu His Leu Glu His Asn Asp Leu Val Lys 
    210                 215                 220             


<210>  8046
<211>  522
<212>  PRT
<213>  Homo Sapiens

<400>  8046

Met Asp Phe Leu Leu Leu Gly Leu Cys Leu Tyr Trp Leu Leu Arg Arg 
1               5                   10                  15      


Pro Ser Gly Val Val Leu Cys Leu Leu Gly Ala Cys Phe Gln Met Leu 
            20                  25                  30          


Pro Ala Ala Pro Ser Gly Cys Pro Gln Leu Cys Arg Cys Glu Gly Arg 
        35                  40                  45              


Leu Leu Tyr Cys Glu Ala Leu Asn Leu Thr Glu Ala Pro His Asn Leu 
    50                  55                  60                  


Ser Gly Leu Leu Gly Leu Ser Leu Arg Tyr Asn Ser Leu Ser Glu Leu 
65                  70                  75                  80  


Arg Ala Gly Gln Phe Thr Gly Leu Met Gln Leu Thr Trp Leu Tyr Leu 
                85                  90                  95      


Asp His Asn His Ile Cys Ser Val Gln Gly Asp Ala Phe Gln Lys Leu 
            100                 105                 110         


Arg Arg Val Lys Glu Leu Thr Leu Ser Ser Asn Gln Ile Thr Gln Leu 
        115                 120                 125             


Pro Asn Thr Thr Phe Arg Pro Met Pro Asn Leu Arg Ser Val Asp Leu 
    130                 135                 140                 


Ser Tyr Asn Lys Leu Gln Ala Leu Ala Pro Asp Leu Phe His Gly Leu 
145                 150                 155                 160 


Arg Lys Leu Thr Thr Leu His Met Arg Ala Asn Ala Ile Gln Phe Val 
                165                 170                 175     


Pro Val Arg Ile Phe Gln Asp Cys Arg Ser Leu Lys Phe Leu Asp Ile 
            180                 185                 190         


Gly Tyr Asn Gln Leu Lys Ser Leu Ala Arg Asn Ser Phe Ala Gly Leu 
        195                 200                 205             


Phe Lys Leu Thr Glu Leu His Leu Glu His Asn Asp Leu Val Lys Val 
    210                 215                 220                 


Asn Phe Ala His Phe Pro Arg Leu Ile Ser Leu His Ser Leu Cys Leu 
225                 230                 235                 240 


Arg Arg Asn Lys Val Ala Ile Val Val Ser Ser Leu Asp Trp Val Trp 
                245                 250                 255     


Asn Leu Glu Lys Met Asp Leu Ser Gly Asn Glu Ile Glu Tyr Met Glu 
            260                 265                 270         


Pro His Val Phe Glu Thr Val Pro His Leu Gln Ser Leu Gln Leu Asp 
        275                 280                 285             


Ser Asn Arg Leu Thr Tyr Ile Glu Pro Arg Ile Leu Asn Ser Trp Lys 
    290                 295                 300                 


Ser Leu Thr Ser Ile Thr Leu Ala Gly Asn Leu Trp Asp Cys Gly Arg 
305                 310                 315                 320 


Asn Val Cys Ala Leu Ala Ser Trp Leu Asn Asn Phe Gln Gly Arg Tyr 
                325                 330                 335     


Asp Gly Asn Leu Gln Cys Ala Ser Pro Glu Tyr Ala Gln Gly Glu Asp 
            340                 345                 350         


Val Leu Asp Ala Val Tyr Ala Phe His Leu Cys Glu Asp Gly Ala Glu 
        355                 360                 365             


Pro Thr Ser Gly His Leu Leu Ser Ala Val Thr Asn Arg Ser Asp Leu 
    370                 375                 380                 


Gly Pro Pro Ala Ser Ser Ala Thr Thr Leu Ala Asp Gly Gly Glu Gly 
385                 390                 395                 400 


Gln His Asp Gly Thr Phe Glu Pro Ala Thr Val Ala Leu Pro Gly Gly 
                405                 410                 415     


Glu His Ala Glu Asn Ala Val Gln Ile His Lys Val Val Thr Gly Thr 
            420                 425                 430         


Met Ala Leu Ile Phe Ser Phe Leu Ile Val Val Leu Val Leu Tyr Val 
        435                 440                 445             


Ser Trp Lys Cys Phe Pro Ala Ser Leu Arg Gln Leu Arg Gln Cys Phe 
    450                 455                 460                 


Val Thr Gln Arg Arg Lys Gln Lys Gln Lys Gln Thr Met His Gln Met 
465                 470                 475                 480 


Ala Ala Met Ser Ala Gln Glu Tyr Tyr Val Asp Tyr Lys Pro Asn His 
                485                 490                 495     


Ile Glu Gly Ala Leu Val Ile Ile Asn Glu Tyr Gly Ser Cys Thr Cys 
            500                 505                 510         


His Gln Gln Pro Ala Arg Glu Cys Glu Val 
        515                 520         


<210>  8047
<211>  522
<212>  PRT
<213>  Homo Sapiens

<400>  8047

Met Asp Phe Leu Leu Leu Gly Leu Cys Leu Tyr Trp Leu Leu Arg Arg 
1               5                   10                  15      


Pro Ser Gly Val Val Leu Cys Leu Leu Gly Ala Cys Phe Gln Met Leu 
            20                  25                  30          


Pro Ala Ala Pro Ser Gly Cys Pro Gln Leu Cys Arg Cys Glu Gly Arg 
        35                  40                  45              


Leu Leu Tyr Cys Glu Ala Leu Asn Leu Thr Glu Ala Pro His Asn Leu 
    50                  55                  60                  


Ser Gly Leu Leu Gly Leu Ser Leu Arg Tyr Asn Ser Leu Ser Glu Leu 
65                  70                  75                  80  


Arg Ala Gly Gln Phe Thr Gly Leu Met Gln Leu Thr Trp Leu Tyr Leu 
                85                  90                  95      


Asp His Asn His Ile Cys Ser Val Gln Gly Asp Ala Phe Gln Lys Leu 
            100                 105                 110         


Arg Arg Val Lys Glu Leu Thr Leu Ser Ser Asn Gln Ile Thr Gln Leu 
        115                 120                 125             


Pro Asn Thr Thr Phe Arg Pro Met Pro Asn Leu Arg Ser Val Asp Leu 
    130                 135                 140                 


Ser Tyr Asn Lys Leu Gln Ala Leu Ala Pro Asp Leu Phe His Gly Leu 
145                 150                 155                 160 


Arg Lys Leu Thr Thr Leu His Met Arg Ala Asn Ala Ile Gln Phe Val 
                165                 170                 175     


Pro Val Arg Ile Phe Gln Asp Cys Arg Ser Leu Lys Phe Leu Asp Ile 
            180                 185                 190         


Gly Tyr Asn Gln Leu Lys Ser Leu Ala Arg Asn Ser Phe Ala Gly Leu 
        195                 200                 205             


Phe Lys Leu Thr Glu Leu His Leu Glu His Asn Asp Leu Val Lys Val 
    210                 215                 220                 


Asn Phe Ala His Phe Pro Arg Leu Ile Ser Leu His Ser Leu Cys Leu 
225                 230                 235                 240 


Arg Arg Asn Lys Val Ala Ile Val Val Ser Ser Leu Asp Trp Val Trp 
                245                 250                 255     


Asn Leu Glu Lys Met Asp Leu Ser Gly Asn Glu Ile Glu Tyr Met Glu 
            260                 265                 270         


Pro His Val Phe Glu Thr Val Pro His Leu Gln Ser Leu Gln Leu Asp 
        275                 280                 285             


Ser Asn Arg Leu Thr Tyr Ile Glu Pro Arg Ile Leu Asn Ser Trp Lys 
    290                 295                 300                 


Ser Leu Thr Ser Ile Thr Leu Ala Gly Asn Leu Trp Asp Cys Gly Arg 
305                 310                 315                 320 


Asn Val Cys Ala Leu Ala Ser Trp Leu Asn Asn Phe Gln Gly Arg Tyr 
                325                 330                 335     


Asp Gly Asn Leu Gln Cys Ala Ser Pro Glu Tyr Ala Gln Gly Glu Asp 
            340                 345                 350         


Val Leu Asp Ala Val Tyr Ala Phe His Leu Cys Glu Asp Gly Ala Glu 
        355                 360                 365             


Pro Thr Ser Gly His Leu Leu Ser Ala Val Thr Asn Arg Ser Asp Leu 
    370                 375                 380                 


Gly Pro Pro Ala Ser Ser Ala Thr Thr Leu Ala Asp Gly Gly Glu Gly 
385                 390                 395                 400 


Gln His Asp Gly Thr Phe Glu Pro Ala Thr Val Ala Leu Pro Gly Gly 
                405                 410                 415     


Glu His Ala Glu Asn Ala Val Gln Ile His Lys Val Val Thr Gly Thr 
            420                 425                 430         


Met Ala Leu Ile Phe Ser Phe Leu Ile Val Val Leu Val Leu Tyr Val 
        435                 440                 445             


Ser Trp Lys Cys Phe Pro Ala Ser Leu Arg Gln Leu Arg Gln Cys Phe 
    450                 455                 460                 


Val Thr Gln Arg Arg Lys Gln Lys Gln Lys Gln Thr Met His Gln Met 
465                 470                 475                 480 


Ala Ala Met Ser Ala Gln Glu Tyr Tyr Val Asp Tyr Lys Pro Asn His 
                485                 490                 495     


Ile Glu Gly Ala Leu Val Ile Ile Asn Glu Tyr Gly Ser Cys Thr Cys 
            500                 505                 510         


His Gln Gln Pro Ala Arg Glu Cys Glu Val 
        515                 520         


<210>  8048
<211>  522
<212>  PRT
<213>  Homo Sapiens

<400>  8048

Met Asp Phe Leu Leu Leu Gly Leu Cys Leu Tyr Trp Leu Leu Arg Arg 
1               5                   10                  15      


Pro Ser Gly Val Val Leu Cys Leu Leu Gly Ala Cys Phe Gln Met Leu 
            20                  25                  30          


Pro Ala Ala Pro Ser Gly Cys Pro Gln Leu Cys Arg Cys Glu Gly Arg 
        35                  40                  45              


Leu Leu Tyr Cys Glu Ala Leu Asn Leu Thr Glu Ala Pro His Asn Leu 
    50                  55                  60                  


Ser Gly Leu Leu Gly Leu Ser Leu Arg Tyr Asn Ser Leu Ser Glu Leu 
65                  70                  75                  80  


Arg Ala Gly Gln Phe Thr Gly Leu Met Gln Leu Thr Trp Leu Tyr Leu 
                85                  90                  95      


Asp His Asn His Ile Cys Ser Val Gln Gly Asp Ala Phe Gln Lys Leu 
            100                 105                 110         


Arg Arg Val Lys Glu Leu Thr Leu Ser Ser Asn Gln Ile Thr Gln Leu 
        115                 120                 125             


Pro Asn Thr Thr Phe Arg Pro Met Pro Asn Leu Arg Ser Val Asp Leu 
    130                 135                 140                 


Ser Tyr Asn Lys Leu Gln Ala Leu Ala Pro Asp Leu Phe His Gly Leu 
145                 150                 155                 160 


Arg Lys Leu Thr Thr Leu His Met Arg Ala Asn Ala Ile Gln Phe Val 
                165                 170                 175     


Pro Val Arg Ile Phe Gln Asp Cys Arg Ser Leu Lys Phe Leu Asp Ile 
            180                 185                 190         


Gly Tyr Asn Gln Leu Lys Ser Leu Ala Arg Asn Ser Phe Ala Gly Leu 
        195                 200                 205             


Phe Lys Leu Thr Glu Leu His Leu Glu His Asn Asp Leu Val Lys Val 
    210                 215                 220                 


Asn Phe Ala His Phe Pro Arg Leu Ile Ser Leu His Ser Leu Cys Leu 
225                 230                 235                 240 


Arg Arg Asn Lys Val Ala Ile Val Val Ser Ser Leu Asp Trp Val Trp 
                245                 250                 255     


Asn Leu Glu Lys Met Asp Leu Ser Gly Asn Glu Ile Glu Tyr Met Glu 
            260                 265                 270         


Pro His Val Phe Glu Thr Val Pro His Leu Gln Ser Leu Gln Leu Asp 
        275                 280                 285             


Ser Asn Arg Leu Thr Tyr Ile Glu Pro Arg Ile Leu Asn Ser Trp Lys 
    290                 295                 300                 


Ser Leu Thr Ser Ile Thr Leu Ala Gly Asn Leu Trp Asp Cys Gly Arg 
305                 310                 315                 320 


Asn Val Cys Ala Leu Ala Ser Trp Leu Asn Asn Phe Gln Gly Arg Tyr 
                325                 330                 335     


Asp Gly Asn Leu Gln Cys Ala Ser Pro Glu Tyr Ala Gln Gly Glu Asp 
            340                 345                 350         


Val Leu Asp Ala Val Tyr Ala Phe His Leu Cys Glu Asp Gly Ala Glu 
        355                 360                 365             


Pro Thr Ser Gly His Leu Leu Ser Ala Val Thr Asn Arg Ser Asp Leu 
    370                 375                 380                 


Gly Pro Pro Ala Ser Ser Ala Thr Thr Leu Ala Asp Gly Gly Glu Gly 
385                 390                 395                 400 


Gln His Asp Gly Thr Phe Glu Pro Ala Thr Val Ala Leu Pro Gly Gly 
                405                 410                 415     


Glu His Ala Glu Asn Ala Val Gln Ile His Lys Val Val Thr Gly Thr 
            420                 425                 430         


Met Ala Leu Ile Phe Ser Phe Leu Ile Val Val Leu Val Leu Tyr Val 
        435                 440                 445             


Ser Trp Lys Cys Phe Pro Ala Ser Leu Arg Gln Leu Arg Gln Cys Phe 
    450                 455                 460                 


Val Thr Gln Arg Arg Lys Gln Lys Gln Lys Gln Thr Met His Gln Met 
465                 470                 475                 480 


Ala Ala Met Ser Ala Gln Glu Tyr Tyr Val Asp Tyr Lys Pro Asn His 
                485                 490                 495     


Ile Glu Gly Ala Leu Val Ile Ile Asn Glu Tyr Gly Ser Cys Thr Cys 
            500                 505                 510         


His Gln Gln Pro Ala Arg Glu Cys Glu Val 
        515                 520         


<210>  8049
<211>  522
<212>  PRT
<213>  Homo Sapiens

<400>  8049

Met Asp Phe Leu Leu Leu Gly Leu Cys Leu Tyr Trp Leu Leu Arg Arg 
1               5                   10                  15      


Pro Ser Gly Val Val Leu Cys Leu Leu Gly Ala Cys Phe Gln Met Leu 
            20                  25                  30          


Pro Ala Ala Pro Ser Gly Cys Pro Gln Leu Cys Arg Cys Glu Gly Arg 
        35                  40                  45              


Leu Leu Tyr Cys Glu Ala Leu Asn Leu Thr Glu Ala Pro His Asn Leu 
    50                  55                  60                  


Ser Gly Leu Leu Gly Leu Ser Leu Arg Tyr Asn Ser Leu Ser Glu Leu 
65                  70                  75                  80  


Arg Ala Gly Gln Phe Thr Gly Leu Met Gln Leu Thr Trp Leu Tyr Leu 
                85                  90                  95      


Asp His Asn His Ile Cys Ser Val Gln Gly Asp Ala Phe Gln Lys Leu 
            100                 105                 110         


Arg Arg Val Lys Glu Leu Thr Leu Ser Ser Asn Gln Ile Thr Gln Leu 
        115                 120                 125             


Pro Asn Thr Thr Phe Arg Pro Met Pro Asn Leu Arg Ser Val Asp Leu 
    130                 135                 140                 


Ser Tyr Asn Lys Leu Gln Ala Leu Ala Pro Asp Leu Phe His Gly Leu 
145                 150                 155                 160 


Arg Lys Leu Thr Thr Leu His Met Arg Ala Asn Ala Ile Gln Phe Val 
                165                 170                 175     


Pro Val Arg Ile Phe Gln Asp Cys Arg Ser Leu Lys Phe Leu Asp Ile 
            180                 185                 190         


Gly Tyr Asn Gln Leu Lys Ser Leu Ala Arg Asn Ser Phe Ala Gly Leu 
        195                 200                 205             


Phe Lys Leu Thr Glu Leu His Leu Glu His Asn Asp Leu Val Lys Val 
    210                 215                 220                 


Asn Phe Ala His Phe Pro Arg Leu Ile Ser Leu His Ser Leu Cys Leu 
225                 230                 235                 240 


Arg Arg Asn Lys Val Ala Ile Val Val Ser Ser Leu Asp Trp Val Trp 
                245                 250                 255     


Asn Leu Glu Lys Met Asp Leu Ser Gly Asn Glu Ile Glu Tyr Met Glu 
            260                 265                 270         


Pro His Val Phe Glu Thr Val Pro His Leu Gln Ser Leu Gln Leu Asp 
        275                 280                 285             


Ser Asn Arg Leu Thr Tyr Ile Glu Pro Arg Ile Leu Asn Ser Trp Lys 
    290                 295                 300                 


Ser Leu Thr Ser Ile Thr Leu Ala Gly Asn Leu Trp Asp Cys Gly Arg 
305                 310                 315                 320 


Asn Val Cys Ala Leu Ala Ser Trp Leu Asn Asn Phe Gln Gly Arg Tyr 
                325                 330                 335     


Asp Gly Asn Leu Gln Cys Ala Ser Pro Glu Tyr Ala Gln Gly Glu Asp 
            340                 345                 350         


Val Leu Asp Ala Val Tyr Ala Phe His Leu Cys Glu Asp Gly Ala Glu 
        355                 360                 365             


Pro Thr Ser Gly His Leu Leu Ser Ala Val Thr Asn Arg Ser Asp Leu 
    370                 375                 380                 


Gly Pro Pro Ala Ser Ser Ala Thr Thr Leu Ala Asp Gly Gly Glu Gly 
385                 390                 395                 400 


Gln His Asp Gly Thr Phe Glu Pro Ala Thr Val Ala Leu Pro Gly Gly 
                405                 410                 415     


Glu His Ala Glu Asn Ala Val Gln Ile His Lys Val Val Thr Gly Thr 
            420                 425                 430         


Met Ala Leu Ile Phe Ser Phe Leu Ile Val Val Leu Val Leu Tyr Val 
        435                 440                 445             


Ser Trp Lys Cys Phe Pro Ala Ser Leu Arg Gln Leu Arg Gln Cys Phe 
    450                 455                 460                 


Val Thr Gln Arg Arg Lys Gln Lys Gln Lys Gln Thr Met His Gln Met 
465                 470                 475                 480 


Ala Ala Met Ser Ala Gln Glu Tyr Tyr Val Asp Tyr Lys Pro Asn His 
                485                 490                 495     


Ile Glu Gly Ala Leu Val Ile Ile Asn Glu Tyr Gly Ser Cys Thr Cys 
            500                 505                 510         


His Gln Gln Pro Ala Arg Glu Cys Glu Val 
        515                 520         


<210>  8050
<211>  38
<212>  PRT
<213>  Homo Sapiens

<400>  8050

Met Ala Val Ile Ser Ala Pro Arg Ala Leu Leu Trp Pro Ser Glu Ala 
1               5                   10                  15      


Ala Asp Leu Ala Phe Thr Phe Gln Leu Pro Ala Asp Tyr Pro Ser Thr 
            20                  25                  30          


Pro Val Leu Gly Leu Ser 
        35              


<210>  8051
<211>  516
<212>  PRT
<213>  Homo Sapiens

<400>  8051

Met Gly Leu His Phe Lys Trp Pro Leu Gly Ala Pro Met Leu Ala Ala 
1               5                   10                  15      


Ile Tyr Ala Met Ser Met Val Leu Lys Met Leu Pro Ala Leu Gly Met 
            20                  25                  30          


Ala Cys Pro Pro Lys Cys Arg Cys Glu Lys Leu Leu Phe Tyr Cys Asp 
        35                  40                  45              


Ser Gln Gly Phe His Ser Val Pro Asn Ala Thr Asp Lys Gly Ser Leu 
    50                  55                  60                  


Gly Leu Ser Leu Arg His Asn His Ile Thr Glu Leu Glu Arg Asp Gln 
65                  70                  75                  80  


Phe Ala Ser Phe Ser Gln Leu Thr Trp Leu His Leu Asp His Asn Gln 
                85                  90                  95      


Ile Ser Thr Val Lys Glu Asp Ala Phe Gln Gly Leu Tyr Lys Leu Lys 
            100                 105                 110         


Glu Leu Ile Leu Ser Ser Asn Lys Ile Phe Tyr Leu Pro Asn Thr Thr 
        115                 120                 125             


Phe Thr Gln Leu Ile Asn Leu Gln Asn Leu Asp Leu Ser Phe Asn Gln 
    130                 135                 140                 


Leu Ser Ser Leu His Pro Glu Leu Phe Tyr Gly Leu Arg Lys Leu Gln 
145                 150                 155                 160 


Thr Leu His Leu Arg Ser Asn Ser Leu Arg Thr Ile Pro Val Arg Leu 
                165                 170                 175     


Phe Trp Asp Cys Arg Ser Leu Glu Phe Leu Asp Leu Ser Thr Asn Arg 
            180                 185                 190         


Leu Arg Ser Leu Ala Arg Asn Gly Phe Ala Gly Leu Ile Lys Leu Arg 
        195                 200                 205             


Glu Leu His Leu Glu His Asn Gln Leu Thr Lys Ile Asn Phe Ala His 
    210                 215                 220                 


Phe Leu Arg Leu Ser Ser Leu His Thr Leu Phe Leu Gln Trp Asn Lys 
225                 230                 235                 240 


Ile Ser Asn Leu Thr Cys Gly Met Glu Trp Thr Trp Gly Thr Leu Glu 
                245                 250                 255     


Lys Leu Asp Leu Thr Gly Asn Glu Ile Lys Ala Ile Asp Leu Thr Val 
            260                 265                 270         


Phe Glu Thr Met Pro Asn Leu Lys Ile Leu Leu Met Asp Asn Asn Lys 
        275                 280                 285             


Leu Asn Ser Leu Asp Ser Lys Ile Leu Asn Ser Leu Arg Ser Leu Thr 
    290                 295                 300                 


Thr Val Gly Leu Ser Gly Asn Leu Trp Glu Cys Ser Ala Arg Ile Cys 
305                 310                 315                 320 


Ala Leu Ala Ser Trp Leu Gly Ser Phe Gln Gly Arg Trp Glu His Ser 
                325                 330                 335     


Ile Leu Cys His Ser Pro Asp His Thr Gln Gly Glu Asp Ile Leu Asp 
            340                 345                 350         


Ala Val His Gly Phe Gln Leu Cys Trp Asn Leu Ser Thr Thr Val Thr 
        355                 360                 365             


Val Met Ala Thr Thr Tyr Arg Asp Pro Thr Thr Glu Tyr Thr Lys Arg 
    370                 375                 380                 


Ile Ser Ser Ser Ser Tyr His Val Gly Asp Lys Glu Ile Pro Thr Thr 
385                 390                 395                 400 


Ala Gly Ile Ala Val Thr Thr Glu Glu His Phe Pro Glu Pro Asp Asn 
                405                 410                 415     


Ala Ile Phe Thr Gln Arg Val Ile Thr Gly Thr Met Ala Leu Leu Phe 
            420                 425                 430         


Ser Phe Phe Phe Ile Ile Phe Ile Val Phe Ile Ser Arg Lys Cys Cys 
        435                 440                 445             


Pro Pro Thr Leu Arg Arg Ile Arg Gln Cys Ser Met Val Gln Asn His 
    450                 455                 460                 


Arg Gln Leu Arg Ser Gln Thr Arg Leu His Met Ser Asn Met Ser Asp 
465                 470                 475                 480 


Gln Gly Pro Tyr Asn Glu Tyr Glu Pro Thr His Glu Gly Pro Phe Ile 
                485                 490                 495     


Ile Ile Asn Gly Tyr Gly Gln Cys Lys Cys Gln Gln Leu Pro Tyr Lys 
            500                 505                 510         


Glu Cys Glu Val 
        515     


<210>  8052
<211>  77
<212>  PRT
<213>  Homo Sapiens

<400>  8052

Met Val Phe Ile Ser Arg Lys Cys Cys Pro Pro Thr Leu Arg Arg Ile 
1               5                   10                  15      


Arg Gln Cys Ser Met Val Gln Asn His Arg Gln Leu Arg Ser Gln Thr 
            20                  25                  30          


Arg Leu His Met Ser Asn Met Ser Asp Gln Gly Pro Tyr Asn Glu Tyr 
        35                  40                  45              


Glu Pro Thr His Glu Gly Pro Phe Ile Ile Ile Asn Gly Tyr Gly Gln 
    50                  55                  60                  


Cys Lys Cys Gln Gln Leu Pro Tyr Lys Glu Cys Glu Val 
65                  70                  75          


<210>  8053
<211>  590
<212>  PRT
<213>  Homo Sapiens

<400>  8053

Met Gly Phe His Leu Ile Thr Gln Leu Lys Gly Met Ser Val Val Leu 
1               5                   10                  15      


Val Leu Leu Pro Thr Leu Leu Leu Val Met Leu Thr Gly Ala Gln Arg 
            20                  25                  30          


Ala Cys Pro Lys Asn Cys Arg Cys Asp Gly Lys Ile Val Tyr Cys Glu 
        35                  40                  45              


Ser His Ala Phe Ala Asp Ile Pro Glu Asn Ile Ser Gly Gly Ser Gln 
    50                  55                  60                  


Gly Leu Ser Leu Arg Phe Asn Ser Ile Gln Lys Leu Lys Ser Asn Gln 
65                  70                  75                  80  


Phe Ala Gly Leu Asn Gln Leu Ile Trp Leu Tyr Leu Asp His Asn Tyr 
                85                  90                  95      


Ile Ser Ser Val Asp Glu Asp Ala Phe Gln Gly Ile Arg Arg Leu Lys 
            100                 105                 110         


Glu Leu Ile Leu Ser Ser Asn Lys Ile Thr Tyr Leu His Asn Lys Thr 
        115                 120                 125             


Phe His Pro Val Pro Asn Leu Arg Asn Leu Asp Leu Ser Tyr Asn Lys 
    130                 135                 140                 


Leu Gln Thr Leu Gln Ser Glu Gln Phe Lys Gly Leu Arg Lys Leu Ile 
145                 150                 155                 160 


Ile Leu His Leu Arg Ser Asn Ser Leu Lys Thr Val Pro Ile Arg Val 
                165                 170                 175     


Phe Gln Asp Cys Arg Asn Leu Asp Phe Leu Asp Leu Gly Tyr Asn Arg 
            180                 185                 190         


Leu Arg Ser Leu Ser Arg Asn Ala Phe Ala Gly Leu Leu Lys Leu Lys 
        195                 200                 205             


Glu Leu His Leu Glu His Asn Gln Phe Ser Lys Ile Asn Phe Ala His 
    210                 215                 220                 


Phe Pro Arg Leu Phe Asn Leu Arg Ser Ile Tyr Leu Gln Trp Asn Arg 
225                 230                 235                 240 


Ile Arg Ser Ile Ser Gln Gly Leu Thr Trp Thr Trp Ser Ser Leu His 
                245                 250                 255     


Asn Leu Asp Leu Ser Gly Asn Asp Ile Gln Gly Ile Glu Pro Gly Thr 
            260                 265                 270         


Phe Lys Cys Leu Pro Asn Leu Gln Lys Leu Asn Leu Asp Ser Asn Lys 
        275                 280                 285             


Leu Thr Asn Ile Ser Gln Glu Thr Val Asn Ala Trp Ile Ser Leu Ile 
    290                 295                 300                 


Ser Ile Thr Leu Ser Gly Asn Met Trp Glu Cys Ser Arg Ser Ile Cys 
305                 310                 315                 320 


Pro Leu Phe Tyr Trp Leu Lys Asn Phe Lys Gly Asn Lys Glu Ser Thr 
                325                 330                 335     


Met Ile Cys Ala Gly Pro Lys His Ile Gln Gly Glu Lys Val Ser Asp 
            340                 345                 350         


Ala Val Glu Thr Tyr Asn Ile Cys Ser Glu Val Gln Val Val Asn Thr 
        355                 360                 365             


Glu Arg Ser His Leu Val Pro Gln Thr Pro Gln Lys Pro Leu Ile Ile 
    370                 375                 380                 


Pro Arg Pro Thr Ile Phe Lys Pro Asp Val Thr Gln Ser Thr Phe Glu 
385                 390                 395                 400 


Thr Pro Ser Pro Ser Pro Gly Phe Gln Ile Pro Gly Ala Glu Gln Glu 
                405                 410                 415     


Tyr Glu His Val Ser Phe His Lys Ile Ile Ala Gly Ser Val Ala Leu 
            420                 425                 430         


Phe Leu Ser Val Ala Met Ile Leu Leu Val Ile Tyr Val Ser Trp Lys 
        435                 440                 445             


Arg Tyr Pro Ala Ser Met Lys Gln Leu Gln Gln His Ser Leu Met Lys 
    450                 455                 460                 


Arg Arg Arg Lys Lys Ala Arg Glu Ser Glu Arg Gln Met Asn Ser Pro 
465                 470                 475                 480 


Leu Gln Glu Tyr Tyr Val Asp Tyr Lys Pro Thr Asn Ser Glu Thr Met 
                485                 490                 495     


Asp Ile Ser Val Asn Gly Ser Gly Pro Cys Thr Tyr Thr Ile Ser Gly 
            500                 505                 510         


Ser Arg Glu Cys Glu Met Pro His His Met Lys Pro Leu Pro Tyr Tyr 
        515                 520                 525             


Ser Tyr Asp Gln Pro Val Ile Gly Tyr Cys Gln Ala His Gln Pro Leu 
    530                 535                 540                 


His Val Thr Lys Gly Tyr Glu Thr Val Ser Pro Glu Gln Asp Glu Ser 
545                 550                 555                 560 


Pro Gly Leu Glu Leu Gly Arg Asp His Ser Phe Ile Ala Thr Ile Ala 
                565                 570                 575     


Arg Ser Ala Ala Pro Ala Ile Tyr Leu Glu Arg Ile Ala Asn 
            580                 585                 590 


<210>  8054
<211>  518
<212>  PRT
<213>  Homo Sapiens

<400>  8054

Met Gly Phe His Leu Ile Thr Gln Leu Lys Gly Met Ser Val Val Leu 
1               5                   10                  15      


Val Leu Leu Pro Thr Leu Leu Leu Val Met Leu Thr Gly Ala Gln Arg 
            20                  25                  30          


Ala Cys Pro Lys Asn Cys Arg Cys Asp Gly Lys Ile Val Tyr Cys Glu 
        35                  40                  45              


Ser His Ala Phe Ala Asp Ile Pro Glu Asn Ile Ser Gly Gly Ser Gln 
    50                  55                  60                  


Gly Leu Ser Leu Arg Phe Asn Ser Ile Gln Lys Leu Lys Ser Asn Gln 
65                  70                  75                  80  


Phe Ala Gly Leu Asn Gln Leu Ile Trp Leu Tyr Leu Asp His Asn Tyr 
                85                  90                  95      


Ile Ser Ser Val Asp Glu Asp Ala Phe Gln Gly Ile Arg Arg Leu Lys 
            100                 105                 110         


Glu Leu Ile Leu Ser Ser Asn Lys Ile Thr Tyr Leu His Asn Lys Thr 
        115                 120                 125             


Phe His Pro Val Pro Asn Leu Arg Asn Leu Asp Leu Ser Tyr Asn Lys 
    130                 135                 140                 


Leu Gln Thr Leu Gln Ser Glu Gln Phe Lys Gly Leu Arg Lys Leu Ile 
145                 150                 155                 160 


Ile Leu His Leu Arg Ser Asn Ser Leu Lys Thr Val Pro Ile Arg Val 
                165                 170                 175     


Phe Gln Asp Cys Arg Asn Leu Asp Phe Leu Asp Leu Gly Tyr Asn Arg 
            180                 185                 190         


Leu Arg Ser Leu Ser Arg Asn Ala Phe Ala Gly Leu Leu Lys Leu Lys 
        195                 200                 205             


Glu Leu His Leu Glu His Asn Gln Phe Ser Lys Ile Asn Phe Ala His 
    210                 215                 220                 


Phe Pro Arg Leu Phe Asn Leu Arg Ser Ile Tyr Leu Gln Trp Asn Arg 
225                 230                 235                 240 


Ile Arg Ser Ile Ser Gln Gly Leu Thr Trp Thr Trp Ser Ser Leu His 
                245                 250                 255     


Asn Leu Asp Leu Ser Gly Asn Asp Ile Gln Gly Ile Glu Pro Gly Thr 
            260                 265                 270         


Phe Lys Cys Leu Pro Asn Leu Gln Lys Leu Asn Leu Asp Ser Asn Lys 
        275                 280                 285             


Leu Thr Asn Ile Ser Gln Glu Thr Val Asn Ala Trp Ile Ser Leu Ile 
    290                 295                 300                 


Ser Ile Thr Leu Ser Gly Asn Met Trp Glu Cys Ser Arg Ser Ile Cys 
305                 310                 315                 320 


Pro Leu Phe Tyr Trp Leu Lys Asn Phe Lys Gly Asn Lys Glu Ser Thr 
                325                 330                 335     


Met Ile Cys Ala Gly Pro Lys His Ile Gln Gly Glu Lys Val Ser Asp 
            340                 345                 350         


Ala Val Glu Thr Tyr Asn Ile Cys Ser Glu Val Gln Val Val Asn Thr 
        355                 360                 365             


Glu Arg Ser His Leu Val Pro Gln Thr Pro Gln Lys Pro Leu Ile Ile 
    370                 375                 380                 


Pro Arg Pro Thr Ile Phe Lys Pro Asp Val Thr Gln Ser Thr Phe Glu 
385                 390                 395                 400 


Thr Pro Ser Pro Ser Pro Gly Phe Gln Ile Pro Gly Ala Glu Gln Glu 
                405                 410                 415     


Tyr Glu His Val Ser Phe His Lys Ile Ile Ala Gly Ser Val Ala Leu 
            420                 425                 430         


Phe Leu Ser Val Ala Met Ile Leu Leu Val Ile Tyr Val Ser Trp Lys 
        435                 440                 445             


Arg Tyr Pro Ala Ser Met Lys Gln Leu Gln Gln His Ser Leu Met Lys 
    450                 455                 460                 


Arg Arg Arg Lys Lys Ala Arg Glu Ser Glu Arg Gln Met Asn Ser Pro 
465                 470                 475                 480 


Leu Gln Glu Tyr Tyr Val Asp Tyr Lys Pro Thr Asn Ser Glu Thr Met 
                485                 490                 495     


Asp Ile Ser Val Asn Gly Ser Gly Pro Cys Thr Tyr Thr Ile Ser Gly 
            500                 505                 510         


Ser Arg Glu Cys Glu Val 
        515             


<210>  8055
<211>  590
<212>  PRT
<213>  Homo Sapiens

<400>  8055

Met Gly Phe His Leu Ile Thr Gln Leu Lys Gly Met Ser Val Val Leu 
1               5                   10                  15      


Val Leu Leu Pro Thr Leu Leu Leu Val Met Leu Thr Gly Ala Gln Arg 
            20                  25                  30          


Ala Cys Pro Lys Asn Cys Arg Cys Asp Gly Lys Ile Val Tyr Cys Glu 
        35                  40                  45              


Ser His Ala Phe Ala Asp Ile Pro Glu Asn Ile Ser Gly Gly Ser Gln 
    50                  55                  60                  


Gly Leu Ser Leu Arg Phe Asn Ser Ile Gln Lys Leu Lys Ser Asn Gln 
65                  70                  75                  80  


Phe Ala Gly Leu Asn Gln Leu Ile Trp Leu Tyr Leu Asp His Asn Tyr 
                85                  90                  95      


Ile Ser Ser Val Asp Glu Asp Ala Phe Gln Gly Ile Arg Arg Leu Lys 
            100                 105                 110         


Glu Leu Ile Leu Ser Ser Asn Lys Ile Thr Tyr Leu His Asn Lys Thr 
        115                 120                 125             


Phe His Pro Val Pro Asn Leu Arg Asn Leu Asp Leu Ser Tyr Asn Lys 
    130                 135                 140                 


Leu Gln Thr Leu Gln Ser Glu Gln Phe Lys Gly Leu Arg Lys Leu Ile 
145                 150                 155                 160 


Ile Leu His Leu Arg Ser Asn Ser Leu Lys Thr Val Pro Ile Arg Val 
                165                 170                 175     


Phe Gln Asp Cys Arg Asn Leu Asp Phe Leu Asp Leu Gly Tyr Asn Arg 
            180                 185                 190         


Leu Arg Ser Leu Ser Arg Asn Ala Phe Ala Gly Leu Leu Lys Leu Lys 
        195                 200                 205             


Glu Leu His Leu Glu His Asn Gln Phe Ser Lys Ile Asn Phe Ala His 
    210                 215                 220                 


Phe Pro Arg Leu Phe Asn Leu Arg Ser Ile Tyr Leu Gln Trp Asn Arg 
225                 230                 235                 240 


Ile Arg Ser Ile Ser Gln Gly Leu Thr Trp Thr Trp Ser Ser Leu His 
                245                 250                 255     


Asn Leu Asp Leu Ser Gly Asn Asp Ile Gln Gly Ile Glu Pro Gly Thr 
            260                 265                 270         


Phe Lys Cys Leu Pro Asn Leu Gln Lys Leu Asn Leu Asp Ser Asn Lys 
        275                 280                 285             


Leu Thr Asn Ile Ser Gln Glu Thr Val Asn Ala Trp Ile Ser Leu Ile 
    290                 295                 300                 


Ser Ile Thr Leu Ser Gly Asn Met Trp Glu Cys Ser Arg Ser Ile Cys 
305                 310                 315                 320 


Pro Leu Phe Tyr Trp Leu Lys Asn Phe Lys Gly Asn Lys Glu Ser Thr 
                325                 330                 335     


Met Ile Cys Ala Gly Pro Lys His Ile Gln Gly Glu Lys Val Ser Asp 
            340                 345                 350         


Ala Val Glu Thr Tyr Asn Ile Cys Ser Glu Val Gln Val Val Asn Thr 
        355                 360                 365             


Glu Arg Ser His Leu Val Pro Gln Thr Pro Gln Lys Pro Leu Ile Ile 
    370                 375                 380                 


Pro Arg Pro Thr Ile Phe Lys Pro Asp Val Thr Gln Ser Thr Phe Glu 
385                 390                 395                 400 


Thr Pro Ser Pro Ser Pro Gly Phe Gln Ile Pro Gly Ala Glu Gln Glu 
                405                 410                 415     


Tyr Glu His Val Ser Phe His Lys Ile Ile Ala Gly Ser Val Ala Leu 
            420                 425                 430         


Phe Leu Ser Val Ala Met Ile Leu Leu Val Ile Tyr Val Ser Trp Lys 
        435                 440                 445             


Arg Tyr Pro Ala Ser Met Lys Gln Leu Gln Gln His Ser Leu Met Lys 
    450                 455                 460                 


Arg Arg Arg Lys Lys Ala Arg Glu Ser Glu Arg Gln Met Asn Ser Pro 
465                 470                 475                 480 


Leu Gln Glu Tyr Tyr Val Asp Tyr Lys Pro Thr Asn Ser Glu Thr Met 
                485                 490                 495     


Asp Ile Ser Val Asn Gly Ser Gly Pro Cys Thr Tyr Thr Ile Ser Gly 
            500                 505                 510         


Ser Arg Glu Cys Glu Met Pro His His Met Lys Pro Leu Pro Tyr Tyr 
        515                 520                 525             


Ser Tyr Asp Gln Pro Val Ile Gly Tyr Cys Gln Ala His Gln Pro Leu 
    530                 535                 540                 


His Val Thr Lys Gly Tyr Glu Thr Val Ser Pro Glu Gln Asp Glu Ser 
545                 550                 555                 560 


Pro Gly Leu Glu Leu Gly Arg Asp His Ser Phe Ile Ala Thr Ile Ala 
                565                 570                 575     


Arg Ser Ala Ala Pro Ala Ile Tyr Leu Glu Arg Ile Ala Asn 
            580                 585                 590 


<210>  8056
<211>  591
<212>  PRT
<213>  Homo Sapiens

<400>  8056

Met Pro Gly Phe His Leu Ile Thr Gln Leu Lys Gly Met Ser Val Val 
1               5                   10                  15      


Leu Val Leu Leu Pro Thr Leu Leu Leu Val Met Leu Thr Gly Ala Gln 
            20                  25                  30          


Arg Ala Cys Pro Lys Asn Cys Arg Cys Asp Gly Lys Ile Val Tyr Cys 
        35                  40                  45              


Glu Ser His Ala Phe Ala Asp Ile Pro Glu Asn Ile Ser Gly Gly Ser 
    50                  55                  60                  


Gln Gly Leu Ser Leu Arg Phe Asn Ser Ile Gln Lys Leu Lys Ser Asn 
65                  70                  75                  80  


Gln Phe Ala Gly Leu Asn Gln Leu Ile Trp Leu Tyr Leu Asp His Asn 
                85                  90                  95      


Tyr Ile Ser Ser Val Asp Glu Asp Ala Phe Gln Gly Ile Arg Arg Leu 
            100                 105                 110         


Lys Glu Leu Ile Leu Ser Ser Asn Lys Ile Thr Tyr Leu His Asn Lys 
        115                 120                 125             


Thr Phe His Pro Val Pro Asn Leu Arg Asn Leu Asp Leu Ser Tyr Asn 
    130                 135                 140                 


Lys Leu Gln Thr Leu Gln Ser Glu Gln Phe Lys Gly Leu Arg Lys Leu 
145                 150                 155                 160 


Ile Ile Leu His Leu Arg Ser Asn Ser Leu Lys Thr Val Pro Ile Arg 
                165                 170                 175     


Val Phe Gln Asp Cys Arg Asn Leu Asp Phe Leu Asp Leu Gly Tyr Asn 
            180                 185                 190         


Arg Leu Arg Ser Leu Ser Arg Asn Ala Phe Ala Gly Leu Leu Lys Leu 
        195                 200                 205             


Lys Glu Leu His Leu Glu His Asn Gln Phe Ser Lys Ile Asn Phe Ala 
    210                 215                 220                 


His Phe Pro Arg Leu Phe Asn Leu Arg Ser Ile Tyr Leu Gln Trp Asn 
225                 230                 235                 240 


Arg Ile Arg Ser Ile Ser Gln Gly Leu Thr Trp Thr Trp Ser Ser Leu 
                245                 250                 255     


His Asn Leu Asp Leu Ser Gly Asn Asp Ile Gln Gly Ile Glu Pro Gly 
            260                 265                 270         


Thr Phe Lys Cys Leu Pro Asn Leu Gln Lys Leu Asn Leu Asp Ser Asn 
        275                 280                 285             


Lys Leu Thr Asn Ile Ser Gln Glu Thr Val Asn Ala Trp Ile Ser Leu 
    290                 295                 300                 


Ile Ser Ile Thr Leu Ser Gly Asn Met Trp Glu Cys Ser Arg Ser Ile 
305                 310                 315                 320 


Cys Pro Leu Phe Tyr Trp Leu Lys Asn Phe Lys Gly Asn Lys Glu Ser 
                325                 330                 335     


Thr Met Ile Cys Ala Gly Pro Lys His Ile Gln Gly Glu Lys Val Ser 
            340                 345                 350         


Asp Ala Val Glu Thr Tyr Asn Ile Cys Ser Glu Val Gln Val Val Asn 
        355                 360                 365             


Thr Glu Arg Ser His Leu Val Pro Gln Thr Pro Gln Lys Pro Leu Ile 
    370                 375                 380                 


Ile Pro Arg Pro Thr Ile Phe Lys Pro Asp Val Thr Gln Ser Thr Phe 
385                 390                 395                 400 


Glu Thr Pro Ser Pro Ser Pro Gly Phe Gln Ile Pro Gly Ala Glu Gln 
                405                 410                 415     


Glu Tyr Glu His Val Ser Phe His Lys Ile Ile Ala Gly Ser Val Ala 
            420                 425                 430         


Leu Phe Leu Ser Val Ala Met Ile Leu Leu Val Ile Tyr Val Ser Trp 
        435                 440                 445             


Lys Arg Tyr Pro Ala Ser Met Lys Gln Leu Gln Gln His Ser Leu Met 
    450                 455                 460                 


Lys Arg Arg Arg Lys Lys Ala Arg Glu Ser Glu Arg Gln Met Asn Ser 
465                 470                 475                 480 


Pro Leu Gln Glu Tyr Tyr Val Asp Tyr Lys Pro Thr Asn Ser Glu Thr 
                485                 490                 495     


Met Asp Ile Ser Val Asn Gly Ser Gly Pro Cys Thr Tyr Thr Ile Ser 
            500                 505                 510         


Gly Ser Arg Glu Cys Glu Met Pro His His Met Lys Pro Leu Pro Tyr 
        515                 520                 525             


Tyr Ser Tyr Asp Gln Pro Val Ile Gly Tyr Cys Gln Ala His Gln Pro 
    530                 535                 540                 


Leu His Val Thr Lys Gly Tyr Glu Thr Val Ser Pro Glu Gln Asp Glu 
545                 550                 555                 560 


Ser Pro Gly Leu Glu Leu Gly Arg Asp His Ser Phe Ile Ala Thr Ile 
                565                 570                 575     


Ala Arg Ser Ala Ala Pro Ala Ile Tyr Leu Glu Arg Ile Ala Asn 
            580                 585                 590     


<210>  8057
<211>  519
<212>  PRT
<213>  Homo Sapiens

<400>  8057

Met Pro Gly Phe His Leu Ile Thr Gln Leu Lys Gly Met Ser Val Val 
1               5                   10                  15      


Leu Val Leu Leu Pro Thr Leu Leu Leu Val Met Leu Thr Gly Ala Gln 
            20                  25                  30          


Arg Ala Cys Pro Lys Asn Cys Arg Cys Asp Gly Lys Ile Val Tyr Cys 
        35                  40                  45              


Glu Ser His Ala Phe Ala Asp Ile Pro Glu Asn Ile Ser Gly Gly Ser 
    50                  55                  60                  


Gln Gly Leu Ser Leu Arg Phe Asn Ser Ile Gln Lys Leu Lys Ser Asn 
65                  70                  75                  80  


Gln Phe Ala Gly Leu Asn Gln Leu Ile Trp Leu Tyr Leu Asp His Asn 
                85                  90                  95      


Tyr Ile Ser Ser Val Asp Glu Asp Ala Phe Gln Gly Ile Arg Arg Leu 
            100                 105                 110         


Lys Glu Leu Ile Leu Ser Ser Asn Lys Ile Thr Tyr Leu His Asn Lys 
        115                 120                 125             


Thr Phe His Pro Val Pro Asn Leu Arg Asn Leu Asp Leu Ser Tyr Asn 
    130                 135                 140                 


Lys Leu Gln Thr Leu Gln Ser Glu Gln Phe Lys Gly Leu Arg Lys Leu 
145                 150                 155                 160 


Ile Ile Leu His Leu Arg Ser Asn Ser Leu Lys Thr Val Pro Ile Arg 
                165                 170                 175     


Val Phe Gln Asp Cys Arg Asn Leu Asp Phe Leu Asp Leu Gly Tyr Asn 
            180                 185                 190         


Arg Leu Arg Ser Leu Ser Arg Asn Ala Phe Ala Gly Leu Leu Lys Leu 
        195                 200                 205             


Lys Glu Leu His Leu Glu His Asn Gln Phe Ser Lys Ile Asn Phe Ala 
    210                 215                 220                 


His Phe Pro Arg Leu Phe Asn Leu Arg Ser Ile Tyr Leu Gln Trp Asn 
225                 230                 235                 240 


Arg Ile Arg Ser Ile Ser Gln Gly Leu Thr Trp Thr Trp Ser Ser Leu 
                245                 250                 255     


His Asn Leu Asp Leu Ser Gly Asn Asp Ile Gln Gly Ile Glu Pro Gly 
            260                 265                 270         


Thr Phe Lys Cys Leu Pro Asn Leu Gln Lys Leu Asn Leu Asp Ser Asn 
        275                 280                 285             


Lys Leu Thr Asn Ile Ser Gln Glu Thr Val Asn Ala Trp Ile Ser Leu 
    290                 295                 300                 


Ile Ser Ile Thr Leu Ser Gly Asn Met Trp Glu Cys Ser Arg Ser Ile 
305                 310                 315                 320 


Cys Pro Leu Phe Tyr Trp Leu Lys Asn Phe Lys Gly Asn Lys Glu Ser 
                325                 330                 335     


Thr Met Ile Cys Ala Gly Pro Lys His Ile Gln Gly Glu Lys Val Ser 
            340                 345                 350         


Asp Ala Val Glu Thr Tyr Asn Ile Cys Ser Glu Val Gln Val Val Asn 
        355                 360                 365             


Thr Glu Arg Ser His Leu Val Pro Gln Thr Pro Gln Lys Pro Leu Ile 
    370                 375                 380                 


Ile Pro Arg Pro Thr Ile Phe Lys Pro Asp Val Thr Gln Ser Thr Phe 
385                 390                 395                 400 


Glu Thr Pro Ser Pro Ser Pro Gly Phe Gln Ile Pro Gly Ala Glu Gln 
                405                 410                 415     


Glu Tyr Glu His Val Ser Phe His Lys Ile Ile Ala Gly Ser Val Ala 
            420                 425                 430         


Leu Phe Leu Ser Val Ala Met Ile Leu Leu Val Ile Tyr Val Ser Trp 
        435                 440                 445             


Lys Arg Tyr Pro Ala Ser Met Lys Gln Leu Gln Gln His Ser Leu Met 
    450                 455                 460                 


Lys Arg Arg Arg Lys Lys Ala Arg Glu Ser Glu Arg Gln Met Asn Ser 
465                 470                 475                 480 


Pro Leu Gln Glu Tyr Tyr Val Asp Tyr Lys Pro Thr Asn Ser Glu Thr 
                485                 490                 495     


Met Asp Ile Ser Val Asn Gly Ser Gly Pro Cys Thr Tyr Thr Ile Ser 
            500                 505                 510         


Gly Ser Arg Glu Cys Glu Val 
        515                 


<210>  8058
<211>  24
<212>  PRT
<213>  Homo Sapiens

<400>  8058

Met Ser Val Val Leu Val Leu Leu Pro Thr Leu Leu Leu Val Met Leu 
1               5                   10                  15      


Thr Gly Ala Gln Arg Ala Cys Pro 
            20                  


<210>  8059
<211>  93
<212>  PRT
<213>  Homo Sapiens

<400>  8059

Met Leu Ala Pro Gly Ser Ser Pro Gly Gln Arg Gly Arg Leu Ala Leu 
1               5                   10                  15      


Gln Trp Arg Gln Val Ser Trp Ile Thr Cys Trp Ile Ala Leu Tyr Ala 
            20                  25                  30          


Val Glu Ala Leu Pro Thr Cys Pro Phe Ser Cys Lys Cys Asp Ser Arg 
        35                  40                  45              


Ser Leu Glu Val Asp Cys Ser Gly Leu Gly Leu Thr Thr Val Pro Pro 
    50                  55                  60                  


Asp Val Pro Ala Ala Thr Arg Thr Leu Leu Leu Leu Asn Asn Lys Leu 
65                  70                  75                  80  


Ser Ala Leu Pro Ser Trp Ala Phe Ala Asn Leu Ser Ser 
                85                  90              


<210>  8060
<211>  96
<212>  PRT
<213>  Homo Sapiens

<400>  8060

Met Leu Ala Pro Gly Ser Ser Pro Gly Gln Arg Gly Arg Leu Ala Leu 
1               5                   10                  15      


Gln Trp Arg Gln Val Ser Trp Ile Thr Cys Trp Ile Ala Leu Tyr Ala 
            20                  25                  30          


Val Glu Ala Leu Pro Thr Cys Pro Phe Ser Cys Lys Cys Asp Ser Arg 
        35                  40                  45              


Ser Leu Glu Val Asp Cys Ser Gly Leu Gly Leu Thr Thr Val Pro Pro 
    50                  55                  60                  


Asp Val Pro Ala Ala Thr Arg Thr Leu Leu Leu Leu Asn Asn Lys Leu 
65                  70                  75                  80  


Ser Ala Leu Pro Ser Trp Ala Phe Ala Asn Leu Ser Ser Leu Gln Arg 
                85                  90                  95      


<210>  8061
<211>  370
<212>  PRT
<213>  Homo Sapiens

<400>  8061

Met Leu Ala Pro Gly Ser Ser Pro Gly Gln Arg Gly Arg Leu Ala Leu 
1               5                   10                  15      


Gln Trp Arg Gln Val Ser Trp Ile Thr Cys Trp Ile Ala Leu Tyr Ala 
            20                  25                  30          


Val Glu Ala Leu Pro Thr Cys Pro Phe Ser Cys Lys Cys Asp Ser Arg 
        35                  40                  45              


Ser Leu Glu Val Asp Cys Ser Gly Leu Gly Leu Thr Thr Val Pro Pro 
    50                  55                  60                  


Asp Val Pro Ala Ala Thr Arg Thr Leu Leu Leu Leu Asn Asn Lys Leu 
65                  70                  75                  80  


Ser Ala Leu Pro Ser Trp Ala Phe Ala Asn Leu Ser Ser Leu Gln Arg 
                85                  90                  95      


Leu Asp Leu Ser Asn Asn Phe Leu Asp Arg Leu Pro Arg Ser Ile Phe 
            100                 105                 110         


Gly Asp Leu Thr Asn Leu Thr Glu Leu Gln Leu Arg Asn Asn Ser Ile 
        115                 120                 125             


Arg Thr Leu Asp Arg Asp Leu Leu Arg His Ser Pro Leu Leu Arg His 
    130                 135                 140                 


Leu Asp Leu Ser Ile Asn Gly Leu Ala Gln Leu Pro Pro Gly Leu Phe 
145                 150                 155                 160 


Asp Gly Leu Leu Ala Leu Arg Ser Leu Ser Leu Arg Ser Asn Arg Leu 
                165                 170                 175     


Gln Asn Leu Asp Arg Leu Thr Phe Glu Pro Leu Ala Asn Leu Gln Leu 
            180                 185                 190         


Leu Gln Val Gly Asp Asn Pro Trp Glu Cys Asp Cys Asn Leu Arg Glu 
        195                 200                 205             


Phe Lys His Trp Met Glu Trp Phe Ser Tyr Arg Gly Gly Arg Leu Asp 
    210                 215                 220                 


Gln Leu Ala Cys Thr Leu Pro Lys Glu Leu Arg Gly Lys Asp Met Arg 
225                 230                 235                 240 


Met Val Pro Met Glu Met Phe Asn Tyr Cys Ser Gln Leu Glu Asp Glu 
                245                 250                 255     


Asn Ser Ser Ala Gly Leu Asp Ile Pro Gly Pro Pro Cys Thr Lys Ala 
            260                 265                 270         


Ser Pro Glu Pro Ala Lys Pro Lys Pro Gly Ala Glu Pro Glu Pro Glu 
        275                 280                 285             


Pro Ser Thr Ala Cys Pro Gln Lys Gln Arg His Arg Pro Ala Ser Val 
    290                 295                 300                 


Arg Arg Ala Met Gly Thr Val Ile Ile Ala Gly Val Val Cys Gly Val 
305                 310                 315                 320 


Val Cys Ile Met Met Val Val Ala Ala Ala Tyr Gly Cys Ile Tyr Ala 
                325                 330                 335     


Ser Leu Met Ala Lys Tyr His Arg Glu Leu Lys Lys Arg Gln Pro Leu 
            340                 345                 350         


Met Gly Asp Pro Glu Gly Glu His Glu Asp Gln Lys Gln Ile Ser Ser 
        355                 360                 365             


Val Ala 
    370 


<210>  8062
<211>  370
<212>  PRT
<213>  Homo Sapiens

<400>  8062

Met Leu Ala Pro Gly Ser Ser Pro Gly Gln Arg Gly Arg Leu Ala Leu 
1               5                   10                  15      


Gln Trp Arg Gln Val Ser Trp Ile Thr Cys Trp Ile Ala Leu Tyr Ala 
            20                  25                  30          


Val Glu Ala Leu Pro Thr Cys Pro Phe Ser Cys Lys Cys Asp Ser Arg 
        35                  40                  45              


Ser Leu Glu Val Asp Cys Ser Gly Leu Gly Leu Thr Thr Val Pro Pro 
    50                  55                  60                  


Asp Val Pro Ala Ala Thr Arg Thr Leu Leu Leu Leu Asn Asn Lys Leu 
65                  70                  75                  80  


Ser Ala Leu Pro Ser Trp Ala Phe Ala Asn Leu Ser Ser Leu Gln Arg 
                85                  90                  95      


Leu Asp Leu Ser Asn Asn Phe Leu Asp Arg Leu Pro Arg Ser Ile Phe 
            100                 105                 110         


Gly Asp Leu Thr Asn Leu Thr Glu Leu Gln Leu Arg Asn Asn Ser Ile 
        115                 120                 125             


Arg Thr Leu Asp Arg Asp Leu Leu Arg His Ser Pro Leu Leu Arg His 
    130                 135                 140                 


Leu Asp Leu Ser Ile Asn Gly Leu Ala Gln Leu Pro Pro Gly Leu Phe 
145                 150                 155                 160 


Asp Gly Leu Leu Ala Leu Arg Ser Leu Ser Leu Arg Ser Asn Arg Leu 
                165                 170                 175     


Gln Asn Leu Asp Arg Leu Thr Phe Glu Pro Leu Ala Asn Leu Gln Leu 
            180                 185                 190         


Leu Gln Val Gly Asp Asn Pro Trp Glu Cys Asp Cys Asn Leu Arg Glu 
        195                 200                 205             


Phe Lys His Trp Met Glu Trp Phe Ser Tyr Arg Gly Gly Arg Leu Asp 
    210                 215                 220                 


Gln Leu Ala Cys Thr Leu Pro Lys Glu Leu Arg Gly Lys Asp Met Arg 
225                 230                 235                 240 


Met Val Pro Met Glu Met Phe Asn Tyr Cys Ser Gln Leu Glu Asp Glu 
                245                 250                 255     


Asn Ser Ser Ala Gly Leu Asp Ile Pro Gly Pro Pro Cys Thr Lys Ala 
            260                 265                 270         


Ser Pro Glu Pro Ala Lys Pro Lys Pro Gly Ala Glu Pro Glu Pro Glu 
        275                 280                 285             


Pro Ser Thr Ala Cys Pro Gln Lys Gln Arg His Arg Pro Ala Ser Val 
    290                 295                 300                 


Arg Arg Ala Met Gly Thr Val Ile Ile Ala Gly Val Val Cys Gly Val 
305                 310                 315                 320 


Val Cys Ile Met Met Val Val Ala Ala Ala Tyr Gly Cys Ile Tyr Ala 
                325                 330                 335     


Ser Leu Met Ala Lys Tyr His Arg Glu Leu Lys Lys Arg Gln Pro Leu 
            340                 345                 350         


Met Gly Asp Pro Glu Gly Glu His Glu Asp Gln Lys Gln Ile Ser Ser 
        355                 360                 365             


Val Ala 
    370 


<210>  8063
<211>  370
<212>  PRT
<213>  Homo Sapiens

<400>  8063

Met Leu Ala Pro Gly Ser Ser Pro Gly Gln Arg Gly Arg Leu Ala Leu 
1               5                   10                  15      


Gln Trp Arg Gln Val Ser Trp Ile Thr Cys Trp Ile Ala Leu Tyr Ala 
            20                  25                  30          


Val Glu Ala Leu Pro Thr Cys Pro Phe Ser Cys Lys Cys Asp Ser Arg 
        35                  40                  45              


Ser Leu Glu Val Asp Cys Ser Gly Leu Gly Leu Thr Thr Val Pro Pro 
    50                  55                  60                  


Asp Val Pro Ala Ala Thr Arg Thr Leu Leu Leu Leu Asn Asn Lys Leu 
65                  70                  75                  80  


Ser Ala Leu Pro Ser Trp Ala Phe Ala Asn Leu Ser Ser Leu Gln Arg 
                85                  90                  95      


Leu Asp Leu Ser Asn Asn Phe Leu Asp Arg Leu Pro Arg Ser Ile Phe 
            100                 105                 110         


Gly Asp Leu Thr Asn Leu Thr Glu Leu Gln Leu Arg Asn Asn Ser Ile 
        115                 120                 125             


Arg Thr Leu Asp Arg Asp Leu Leu Arg His Ser Pro Leu Leu Arg His 
    130                 135                 140                 


Leu Asp Leu Ser Ile Asn Gly Leu Ala Gln Leu Pro Pro Gly Leu Phe 
145                 150                 155                 160 


Asp Gly Leu Leu Ala Leu Arg Ser Leu Ser Leu Arg Ser Asn Arg Leu 
                165                 170                 175     


Gln Asn Leu Asp Arg Leu Thr Phe Glu Pro Leu Ala Asn Leu Gln Leu 
            180                 185                 190         


Leu Gln Val Gly Asp Asn Pro Trp Glu Cys Asp Cys Asn Leu Arg Glu 
        195                 200                 205             


Phe Lys His Trp Met Glu Trp Phe Ser Tyr Arg Gly Gly Arg Leu Asp 
    210                 215                 220                 


Gln Leu Ala Cys Thr Leu Pro Lys Glu Leu Arg Gly Lys Asp Met Arg 
225                 230                 235                 240 


Met Val Pro Met Glu Met Phe Asn Tyr Cys Ser Gln Leu Glu Asp Glu 
                245                 250                 255     


Asn Ser Ser Ala Gly Leu Asp Ile Pro Gly Pro Pro Cys Thr Lys Ala 
            260                 265                 270         


Ser Pro Glu Pro Ala Lys Pro Lys Pro Gly Ala Glu Pro Glu Pro Glu 
        275                 280                 285             


Pro Ser Thr Ala Cys Pro Gln Lys Gln Arg His Arg Pro Ala Ser Val 
    290                 295                 300                 


Arg Arg Ala Met Gly Thr Val Ile Ile Ala Gly Val Val Cys Gly Val 
305                 310                 315                 320 


Val Cys Ile Met Met Val Val Ala Ala Ala Tyr Gly Cys Ile Tyr Ala 
                325                 330                 335     


Ser Leu Met Ala Lys Tyr His Arg Glu Leu Lys Lys Arg Gln Pro Leu 
            340                 345                 350         


Met Gly Asp Pro Glu Gly Glu His Glu Asp Gln Lys Gln Ile Ser Ser 
        355                 360                 365             


Val Ala 
    370 


<210>  8064
<211>  114
<212>  PRT
<213>  Homo Sapiens

<400>  8064

Asp Ser Val Arg Thr Val Arg Val Val Ala Thr Lys Gln Gly Asn Ala 
1               5                   10                  15      


Val Thr Leu Gly Asp Tyr Tyr Gln Gly Arg Arg Ile Thr Ile Thr Gly 
            20                  25                  30          


Asn Ala Asp Leu Thr Phe Asp Gln Thr Ala Trp Gly Asp Ser Gly Val 
        35                  40                  45              


Tyr Tyr Cys Ser Val Val Ser Ala Gln Asp Leu Gln Gly Asn Asn Glu 
    50                  55                  60                  


Ala Tyr Ala Glu Leu Ile Val Leu Gly Arg Thr Ser Gly Val Ala Glu 
65                  70                  75                  80  


Leu Leu Pro Gly Phe Gln Ala Gly Pro Ile Glu Val Tyr Ala Ala Gly 
                85                  90                  95      


Lys Ala Ala Thr Ser Gly Val Pro Ser Ile Tyr Ala Pro Ser Thr Tyr 
            100                 105                 110         


Ala His 
        


<210>  8065
<211>  493
<212>  PRT
<213>  Homo Sapiens

<400>  8065

Met Ala Leu Leu Ala Gly Gly Leu Ser Arg Gly Leu Gly Ser His Pro 
1               5                   10                  15      


Ala Ala Ala Gly Arg Asp Ala Val Val Phe Val Trp Leu Leu Leu Ser 
            20                  25                  30          


Thr Trp Cys Thr Ala Pro Ala Arg Ala Ile Gln Val Thr Val Ser Asn 
        35                  40                  45              


Pro Tyr His Val Val Ile Leu Phe Gln Pro Val Thr Leu Pro Cys Thr 
    50                  55                  60                  


Tyr Gln Met Thr Ser Thr Pro Thr Gln Pro Ile Val Ile Trp Lys Tyr 
65                  70                  75                  80  


Lys Ser Phe Cys Arg Asp Arg Ile Ala Asp Ala Phe Ser Pro Ala Ser 
                85                  90                  95      


Val Asp Asn Gln Leu Asn Ala Gln Leu Ala Ala Gly Asn Pro Gly Tyr 
            100                 105                 110         


Asn Pro Tyr Val Glu Cys Gln Asp Ser Val Arg Thr Val Arg Val Val 
        115                 120                 125             


Ala Thr Lys Gln Gly Asn Ala Val Thr Leu Gly Asp Tyr Tyr Gln Gly 
    130                 135                 140                 


Arg Arg Ile Thr Ile Thr Gly Met Tyr Ala Ala Gly Lys Ala Ala Thr 
145                 150                 155                 160 


Ser Gly Val Pro Ser Ile Tyr Ala Pro Ser Thr Tyr Ala His Leu Ser 
                165                 170                 175     


Pro Ala Lys Thr Pro Pro Pro Pro Ala Met Ile Pro Met Gly Pro Ala 
            180                 185                 190         


Tyr Asn Gly Tyr Pro Gly Gly Tyr Pro Gly Asp Val Asp Arg Ser Ser 
        195                 200                 205             


Ser Ala Gly Gly Gln Gly Ser Tyr Val Pro Leu Leu Arg Asp Thr Asp 
    210                 215                 220                 


Ser Ser Val Ala Ser Glu Val Arg Ser Gly Tyr Arg Ile Gln Ala Ser 
225                 230                 235                 240 


Gln Gln Asp Asp Ser Met Arg Val Leu Tyr Tyr Met Glu Lys Glu Leu 
                245                 250                 255     


Ala Asn Phe Asp Pro Ser Arg Pro Gly Pro Pro Ser Gly Arg Val Glu 
            260                 265                 270         


Arg Ala Met Ser Glu Val Thr Ser Leu His Glu Asp Asp Trp Arg Ser 
        275                 280                 285             


Arg Pro Ser Arg Gly Pro Ala Leu Thr Pro Ile Arg Asp Glu Glu Trp 
    290                 295                 300                 


Gly Gly His Ser Pro Arg Ser Pro Arg Gly Trp Asp Gln Glu Pro Ala 
305                 310                 315                 320 


Arg Glu Gln Ala Gly Gly Gly Trp Arg Ala Arg Arg Pro Arg Ala Arg 
                325                 330                 335     


Ser Val Asp Ala Leu Asp Asp Leu Thr Pro Pro Ser Thr Ala Glu Ser 
            340                 345                 350         


Gly Ser Arg Ser Pro Thr Ser Asn Gly Gly Arg Ser Arg Ala Tyr Met 
        355                 360                 365             


Pro Pro Arg Ser Arg Ser Arg Asp Asp Leu Tyr Asp Gln Asp Asp Ser 
    370                 375                 380                 


Arg Asp Phe Pro Arg Ser Arg Asp Pro His Tyr Asp Asp Phe Arg Ser 
385                 390                 395                 400 


Arg Glu Arg Pro Pro Ala Asp Pro Arg Ser His His His Arg Thr Arg 
                405                 410                 415     


Asp Pro Arg Asp Asn Gly Ser Arg Ser Gly Asp Leu Pro Tyr Asp Gly 
            420                 425                 430         


Arg Leu Leu Glu Glu Ala Val Arg Lys Lys Gly Ser Glu Glu Arg Arg 
        435                 440                 445             


Arg Pro His Lys Glu Glu Glu Glu Glu Ala Tyr Tyr Pro Pro Ala Pro 
    450                 455                 460                 


Pro Pro Tyr Ser Glu Thr Asp Ser Gln Ala Ser Arg Glu Arg Arg Leu 
465                 470                 475                 480 


Lys Lys Asn Leu Ala Leu Ser Arg Glu Ser Leu Val Val 
                485                 490             


<210>  8066
<211>  601
<212>  PRT
<213>  Homo Sapiens

<400>  8066

Met Ala Leu Leu Ala Gly Gly Leu Ser Arg Gly Leu Gly Ser His Pro 
1               5                   10                  15      


Ala Ala Ala Gly Arg Asp Ala Val Val Phe Val Trp Leu Leu Leu Ser 
            20                  25                  30          


Thr Trp Cys Thr Ala Pro Ala Arg Ala Ile Gln Val Thr Val Ser Asn 
        35                  40                  45              


Pro Tyr His Val Val Ile Leu Phe Gln Pro Val Thr Leu Pro Cys Thr 
    50                  55                  60                  


Tyr Gln Met Thr Ser Thr Pro Thr Gln Pro Ile Val Ile Trp Lys Tyr 
65                  70                  75                  80  


Lys Ser Phe Cys Arg Asp Arg Ile Ala Asp Ala Phe Ser Pro Ala Ser 
                85                  90                  95      


Val Asp Asn Gln Leu Asn Ala Gln Leu Ala Ala Gly Asn Pro Gly Tyr 
            100                 105                 110         


Asn Pro Tyr Val Glu Cys Gln Asp Ser Val Arg Thr Val Arg Val Val 
        115                 120                 125             


Ala Thr Lys Gln Gly Asn Ala Val Thr Leu Gly Asp Tyr Tyr Gln Gly 
    130                 135                 140                 


Arg Arg Ile Thr Ile Thr Gly Asn Ala Asp Leu Thr Phe Asp Gln Thr 
145                 150                 155                 160 


Ala Trp Gly Asp Ser Gly Val Tyr Tyr Cys Ser Val Val Ser Ala Gln 
                165                 170                 175     


Asp Leu Gln Gly Asn Asn Glu Ala Tyr Ala Glu Leu Ile Val Leu Gly 
            180                 185                 190         


Arg Thr Ser Gly Val Ala Glu Leu Leu Pro Gly Phe Gln Ala Gly Pro 
        195                 200                 205             


Ile Glu Asp Trp Leu Phe Val Val Val Val Cys Leu Ala Ala Phe Leu 
    210                 215                 220                 


Ile Phe Leu Leu Leu Gly Ile Cys Trp Cys Gln Cys Cys Pro His Thr 
225                 230                 235                 240 


Cys Cys Cys Tyr Val Arg Cys Pro Cys Cys Pro Asp Lys Cys Cys Cys 
                245                 250                 255     


Pro Glu Ala Leu Tyr Ala Ala Gly Lys Ala Ala Thr Ser Gly Val Pro 
            260                 265                 270         


Ser Ile Tyr Ala Pro Ser Thr Tyr Ala His Leu Ser Pro Ala Lys Thr 
        275                 280                 285             


Pro Pro Pro Pro Ala Met Ile Pro Met Gly Pro Ala Tyr Asn Gly Tyr 
    290                 295                 300                 


Pro Gly Gly Tyr Pro Gly Asp Val Asp Arg Ser Ser Ser Ala Gly Gly 
305                 310                 315                 320 


Gln Gly Ser Tyr Val Pro Leu Leu Arg Asp Thr Asp Ser Ser Val Ala 
                325                 330                 335     


Ser Glu Val Arg Ser Gly Tyr Arg Ile Gln Ala Ser Gln Gln Asp Asp 
            340                 345                 350         


Ser Met Arg Val Leu Tyr Tyr Met Glu Lys Glu Leu Ala Asn Phe Asp 
        355                 360                 365             


Pro Ser Arg Pro Gly Pro Pro Ser Gly Arg Val Glu Arg Ala Met Ser 
    370                 375                 380                 


Glu Val Thr Ser Leu His Glu Asp Asp Trp Arg Ser Arg Pro Ser Arg 
385                 390                 395                 400 


Gly Pro Ala Leu Thr Pro Ile Arg Asp Glu Glu Trp Gly Gly His Ser 
                405                 410                 415     


Pro Arg Ser Pro Arg Gly Trp Asp Gln Glu Pro Ala Arg Glu Gln Ala 
            420                 425                 430         


Gly Gly Gly Trp Arg Ala Arg Arg Pro Arg Ala Arg Ser Val Asp Ala 
        435                 440                 445             


Leu Asp Asp Leu Thr Pro Pro Ser Thr Ala Glu Ser Gly Ser Arg Ser 
    450                 455                 460                 


Pro Thr Ser Asn Gly Gly Arg Ser Arg Ala Tyr Met Pro Pro Arg Ser 
465                 470                 475                 480 


Arg Ser Arg Asp Asp Leu Tyr Asp Gln Asp Asp Ser Arg Asp Phe Pro 
                485                 490                 495     


Arg Ser Arg Asp Pro His Tyr Asp Asp Phe Arg Ser Arg Glu Arg Pro 
            500                 505                 510         


Pro Ala Asp Pro Arg Ser His His His Arg Thr Arg Asp Pro Arg Asp 
        515                 520                 525             


Asn Gly Ser Arg Ser Gly Asp Leu Pro Tyr Asp Gly Arg Leu Leu Glu 
    530                 535                 540                 


Glu Ala Val Arg Lys Lys Gly Ser Glu Glu Arg Arg Arg Pro His Lys 
545                 550                 555                 560 


Glu Glu Glu Glu Glu Ala Tyr Tyr Pro Pro Ala Pro Pro Pro Tyr Ser 
                565                 570                 575     


Glu Thr Asp Ser Gln Ala Ser Arg Glu Arg Arg Leu Lys Lys Asn Leu 
            580                 585                 590         


Ala Leu Ser Arg Glu Ser Leu Val Val 
        595                 600     


<210>  8067
<211>  591
<212>  PRT
<213>  Homo Sapiens

<400>  8067

Met Gln Gln Asp Gly Leu Gly Val Gly Thr Arg Asn Gly Ser Gly Lys 
1               5                   10                  15      


Gly Arg Ser Val His Pro Ser Trp Pro Trp Cys Ala Pro Arg Pro Leu 
            20                  25                  30          


Arg Tyr Phe Gly Arg Asp Ala Arg Ala Arg Arg Ala Gln Thr Ala Ala 
        35                  40                  45              


Met Ala Leu Ala Ile Gln Val Thr Val Ser Asn Pro Tyr His Val Val 
    50                  55                  60                  


Ile Leu Phe Gln Pro Val Thr Leu Pro Cys Thr Tyr Gln Met Thr Ser 
65                  70                  75                  80  


Thr Pro Thr Gln Pro Ile Val Ile Trp Lys Tyr Lys Ser Phe Cys Arg 
                85                  90                  95      


Asp Arg Ile Ala Asp Ala Phe Ser Pro Ala Ser Val Asp Asn Gln Leu 
            100                 105                 110         


Asn Ala Gln Leu Ala Ala Gly Asn Pro Gly Tyr Asn Pro Tyr Val Glu 
        115                 120                 125             


Cys Gln Asp Ser Val Arg Thr Val Arg Val Val Ala Thr Lys Gln Gly 
    130                 135                 140                 


Asn Ala Val Thr Leu Gly Asp Tyr Tyr Gln Gly Arg Arg Ile Thr Ile 
145                 150                 155                 160 


Thr Gly Asn Ala Asp Leu Thr Phe Asp Gln Thr Ala Trp Gly Asp Ser 
                165                 170                 175     


Gly Val Tyr Tyr Cys Ser Val Val Ser Ala Gln Asp Leu Gln Gly Asn 
            180                 185                 190         


Asn Glu Ala Tyr Ala Glu Leu Ile Val Leu Gly Arg Thr Ser Gly Val 
        195                 200                 205             


Ala Glu Leu Leu Pro Gly Phe Gln Ala Gly Pro Ile Glu Asp Trp Leu 
    210                 215                 220                 


Phe Val Val Val Val Cys Leu Ala Ala Phe Leu Ile Phe Leu Leu Leu 
225                 230                 235                 240 


Gly Ile Cys Trp Cys Gln Cys Cys Pro His Thr Cys Cys Cys Tyr Val 
                245                 250                 255     


Arg Cys Pro Cys Cys Pro Asp Lys Cys Cys Cys Pro Glu Ala Leu Tyr 
            260                 265                 270         


Ala Ala Gly Lys Ala Ala Thr Ser Gly Val Pro Ser Ile Tyr Ala Pro 
        275                 280                 285             


Ser Thr Tyr Ala His Leu Ser Pro Ala Lys Thr Pro Pro Pro Pro Ala 
    290                 295                 300                 


Met Ile Pro Met Gly Pro Ala Tyr Asn Gly Tyr Pro Gly Gly Tyr Pro 
305                 310                 315                 320 


Gly Asp Val Asp Arg Ser Ser Ser Val Arg Ser Gly Tyr Arg Ile Gln 
                325                 330                 335     


Ala Ser Gln Gln Asp Asp Ser Met Arg Val Leu Tyr Tyr Met Glu Lys 
            340                 345                 350         


Glu Leu Ala Asn Phe Asp Pro Ser Arg Pro Gly Pro Pro Ser Gly Arg 
        355                 360                 365             


Val Glu Arg Ala Met Ser Glu Val Thr Ser Leu His Glu Asp Asp Trp 
    370                 375                 380                 


Arg Ser Arg Pro Ser Arg Gly Pro Ala Leu Thr Pro Ile Arg Asp Glu 
385                 390                 395                 400 


Glu Trp Gly Gly His Ser Pro Arg Ser Pro Arg Gly Trp Asp Gln Glu 
                405                 410                 415     


Pro Ala Arg Glu Gln Ala Gly Gly Gly Trp Arg Ala Arg Arg Pro Arg 
            420                 425                 430         


Ala Arg Ser Val Asp Ala Leu Asp Asp Leu Thr Pro Pro Ser Thr Ala 
        435                 440                 445             


Glu Ser Gly Ser Arg Ser Pro Thr Ser Asn Gly Gly Arg Ser Arg Ala 
    450                 455                 460                 


Tyr Met Pro Pro Arg Ser Arg Ser Arg Asp Asp Leu Tyr Asp Gln Asp 
465                 470                 475                 480 


Asp Ser Arg Asp Phe Pro Arg Ser Arg Asp Pro His Tyr Asp Asp Phe 
                485                 490                 495     


Arg Ser Arg Glu Arg Pro Pro Ala Asp Pro Arg Ser His His His Arg 
            500                 505                 510         


Thr Arg Asp Pro Arg Asp Asn Gly Ser Arg Ser Gly Asp Leu Pro Tyr 
        515                 520                 525             


Asp Gly Arg Leu Leu Glu Glu Ala Val Arg Lys Lys Gly Ser Glu Glu 
    530                 535                 540                 


Arg Arg Arg Pro His Lys Glu Glu Glu Glu Glu Ala Tyr Tyr Pro Pro 
545                 550                 555                 560 


Ala Pro Pro Pro Tyr Ser Glu Thr Asp Ser Gln Ala Ser Arg Glu Arg 
                565                 570                 575     


Arg Leu Lys Lys Asn Leu Ala Leu Ser Arg Glu Ser Leu Val Val 
            580                 585                 590     


<210>  8068
<211>  630
<212>  PRT
<213>  Homo Sapiens

<400>  8068

Met Gln Gln Asp Gly Leu Gly Val Gly Thr Arg Asn Gly Ser Gly Lys 
1               5                   10                  15      


Gly Arg Ser Val His Pro Ser Trp Pro Trp Cys Ala Pro Arg Pro Leu 
            20                  25                  30          


Arg Tyr Phe Gly Arg Asp Ala Arg Ala Arg Arg Ala Gln Thr Ala Ala 
        35                  40                  45              


Met Ala Leu Leu Ala Gly Gly Leu Ser Arg Gly Leu Gly Ser His Pro 
    50                  55                  60                  


Ala Ala Ala Gly Arg Asp Ala Val Val Phe Val Trp Leu Leu Leu Ser 
65                  70                  75                  80  


Thr Trp Cys Thr Ala Pro Ala Arg Ala Ile Gln Val Thr Val Ser Asn 
                85                  90                  95      


Pro Tyr His Val Val Ile Leu Phe Gln Pro Val Thr Leu Pro Cys Thr 
            100                 105                 110         


Tyr Gln Met Thr Ser Thr Pro Thr Gln Pro Ile Val Ile Trp Lys Tyr 
        115                 120                 125             


Lys Ser Phe Cys Arg Asp Arg Ile Ala Asp Ala Phe Ser Pro Ala Ser 
    130                 135                 140                 


Val Asp Asn Gln Leu Asn Ala Gln Leu Ala Ala Gly Asn Pro Gly Tyr 
145                 150                 155                 160 


Asn Pro Tyr Val Glu Cys Gln Asp Ser Val Arg Thr Val Arg Val Val 
                165                 170                 175     


Ala Thr Lys Gln Gly Asn Ala Val Thr Leu Gly Asp Tyr Tyr Gln Gly 
            180                 185                 190         


Arg Arg Ile Thr Ile Thr Gly Asn Ala Asp Leu Thr Phe Asp Gln Thr 
        195                 200                 205             


Ala Trp Gly Asp Ser Gly Val Tyr Tyr Cys Ser Val Val Ser Ala Gln 
    210                 215                 220                 


Asp Leu Gln Gly Asn Asn Glu Ala Tyr Ala Glu Leu Ile Val Leu Asp 
225                 230                 235                 240 


Trp Leu Phe Val Val Val Val Cys Leu Ala Ala Phe Leu Ile Phe Leu 
                245                 250                 255     


Leu Leu Gly Ile Cys Trp Cys Gln Cys Cys Pro His Thr Cys Cys Cys 
            260                 265                 270         


Tyr Val Arg Cys Pro Cys Cys Pro Asp Lys Cys Cys Cys Pro Glu Ala 
        275                 280                 285             


Leu Tyr Ala Ala Gly Lys Ala Ala Thr Ser Gly Val Pro Ser Ile Tyr 
    290                 295                 300                 


Ala Pro Ser Thr Tyr Ala His Leu Ser Pro Ala Lys Thr Pro Pro Pro 
305                 310                 315                 320 


Pro Ala Met Ile Pro Met Gly Pro Ala Tyr Asn Gly Tyr Pro Gly Gly 
                325                 330                 335     


Tyr Pro Gly Asp Val Asp Arg Ser Ser Ser Ala Gly Gly Gln Gly Ser 
            340                 345                 350         


Tyr Val Pro Leu Leu Arg Asp Thr Asp Ser Ser Val Ala Ser Glu Val 
        355                 360                 365             


Arg Ser Gly Tyr Arg Ile Gln Ala Ser Gln Gln Asp Asp Ser Met Arg 
    370                 375                 380                 


Val Leu Tyr Tyr Met Glu Lys Glu Leu Ala Asn Phe Asp Pro Ser Arg 
385                 390                 395                 400 


Pro Gly Pro Pro Ser Gly Arg Val Glu Arg Ala Met Ser Glu Val Thr 
                405                 410                 415     


Ser Leu His Glu Asp Asp Trp Arg Ser Arg Pro Ser Arg Gly Pro Ala 
            420                 425                 430         


Leu Thr Pro Ile Arg Asp Glu Glu Trp Gly Gly His Ser Pro Arg Ser 
        435                 440                 445             


Pro Arg Gly Trp Asp Gln Glu Pro Ala Arg Glu Gln Ala Gly Gly Gly 
    450                 455                 460                 


Trp Arg Ala Arg Arg Pro Arg Ala Arg Ser Val Asp Ala Leu Asp Asp 
465                 470                 475                 480 


Leu Thr Pro Pro Ser Thr Ala Glu Ser Gly Ser Arg Ser Pro Thr Ser 
                485                 490                 495     


Asn Gly Gly Arg Ser Arg Ala Tyr Met Pro Pro Arg Ser Arg Ser Arg 
            500                 505                 510         


Asp Asp Leu Tyr Asp Gln Asp Asp Ser Arg Asp Phe Pro Arg Ser Arg 
        515                 520                 525             


Asp Pro His Tyr Asp Asp Phe Arg Ser Arg Glu Arg Pro Pro Ala Asp 
    530                 535                 540                 


Pro Arg Ser His His His Arg Thr Arg Asp Pro Arg Asp Asn Gly Ser 
545                 550                 555                 560 


Arg Ser Gly Asp Leu Pro Tyr Asp Gly Arg Leu Leu Glu Glu Ala Val 
                565                 570                 575     


Arg Lys Lys Gly Ser Glu Glu Arg Arg Arg Pro His Lys Glu Glu Glu 
            580                 585                 590         


Glu Glu Ala Tyr Tyr Pro Pro Ala Pro Pro Pro Tyr Ser Glu Thr Asp 
        595                 600                 605             


Ser Gln Ala Ser Arg Glu Arg Arg Leu Lys Lys Asn Leu Ala Leu Ser 
    610                 615                 620                 


Arg Glu Ser Leu Val Val 
625                 630 


<210>  8069
<211>  629
<212>  PRT
<213>  Homo Sapiens

<400>  8069

Met Gln Gln Asp Gly Leu Gly Val Gly Thr Arg Asn Gly Ser Gly Lys 
1               5                   10                  15      


Gly Arg Ser Val His Pro Ser Trp Pro Trp Cys Ala Pro Arg Pro Leu 
            20                  25                  30          


Arg Tyr Phe Gly Arg Asp Ala Arg Ala Arg Arg Ala Gln Thr Ala Ala 
        35                  40                  45              


Met Ala Leu Leu Ala Gly Gly Leu Ser Arg Gly Leu Gly Ser His Pro 
    50                  55                  60                  


Ala Ala Ala Gly Arg Asp Ala Val Val Phe Val Trp Leu Leu Leu Ser 
65                  70                  75                  80  


Thr Trp Cys Thr Ala Pro Ala Arg Ala Ile Gln Val Thr Val Ser Asn 
                85                  90                  95      


Pro Tyr His Val Val Ile Leu Phe Gln Pro Val Thr Leu Pro Cys Thr 
            100                 105                 110         


Tyr Gln Met Thr Ser Thr Pro Thr Gln Pro Ile Val Ile Trp Lys Tyr 
        115                 120                 125             


Lys Ser Phe Cys Arg Asp Arg Ile Ala Asp Ala Phe Ser Pro Ala Ser 
    130                 135                 140                 


Val Asp Asn Gln Leu Asn Ala Gln Leu Ala Ala Gly Asn Pro Gly Tyr 
145                 150                 155                 160 


Asn Pro Tyr Val Glu Cys Gln Asp Ser Val Arg Thr Val Arg Val Val 
                165                 170                 175     


Ala Thr Lys Gln Gly Asn Ala Val Thr Leu Gly Asp Tyr Tyr Gln Gly 
            180                 185                 190         


Arg Arg Ile Thr Ile Thr Gly Asn Ala Asp Leu Thr Phe Asp Gln Thr 
        195                 200                 205             


Ala Trp Gly Asp Ser Gly Val Tyr Tyr Cys Ser Val Val Ser Ala Gln 
    210                 215                 220                 


Asp Leu Gln Gly Asn Asn Glu Ala Tyr Ala Glu Leu Ile Val Leu Asp 
225                 230                 235                 240 


Trp Leu Phe Val Val Val Val Cys Leu Ala Ala Phe Leu Ile Phe Leu 
                245                 250                 255     


Leu Leu Gly Ile Cys Trp Cys Gln Cys Cys Pro His Thr Cys Cys Cys 
            260                 265                 270         


Tyr Val Arg Cys Pro Cys Cys Pro Asp Lys Cys Cys Cys Pro Glu Ala 
        275                 280                 285             


Leu Tyr Ala Ala Gly Lys Ala Ala Thr Ser Gly Val Pro Ser Ile Tyr 
    290                 295                 300                 


Ala Pro Ser Thr Tyr Ala His Leu Ser Pro Ala Lys Thr Pro Pro Pro 
305                 310                 315                 320 


Pro Ala Met Ile Pro Met Gly Pro Ala Tyr Asn Gly Tyr Pro Gly Gly 
                325                 330                 335     


Tyr Pro Gly Asp Val Asp Arg Ser Ser Ser Ala Gly Gly Gln Gly Ser 
            340                 345                 350         


Tyr Val Pro Leu Leu Arg Asp Thr Asp Ser Ser Val Ala Ser Val Arg 
        355                 360                 365             


Ser Gly Tyr Arg Ile Gln Ala Ser Gln Gln Asp Asp Ser Met Arg Val 
    370                 375                 380                 


Leu Tyr Tyr Met Glu Lys Glu Leu Ala Asn Phe Asp Pro Ser Arg Pro 
385                 390                 395                 400 


Gly Pro Pro Ser Gly Arg Val Glu Arg Ala Met Ser Glu Val Thr Ser 
                405                 410                 415     


Leu His Glu Asp Asp Trp Arg Ser Arg Pro Ser Arg Gly Pro Ala Leu 
            420                 425                 430         


Thr Pro Ile Arg Asp Glu Glu Trp Gly Gly His Ser Pro Arg Ser Pro 
        435                 440                 445             


Arg Gly Trp Asp Gln Glu Pro Ala Arg Glu Gln Ala Gly Gly Gly Trp 
    450                 455                 460                 


Arg Ala Arg Arg Pro Arg Ala Arg Ser Val Asp Ala Leu Asp Asp Leu 
465                 470                 475                 480 


Thr Pro Pro Ser Thr Ala Glu Ser Gly Ser Arg Ser Pro Thr Ser Asn 
                485                 490                 495     


Gly Gly Arg Ser Arg Ala Tyr Met Pro Pro Arg Ser Arg Ser Arg Asp 
            500                 505                 510         


Asp Leu Tyr Asp Gln Asp Asp Ser Arg Asp Phe Pro Arg Ser Arg Asp 
        515                 520                 525             


Pro His Tyr Asp Asp Phe Arg Ser Arg Glu Arg Pro Pro Ala Asp Pro 
    530                 535                 540                 


Arg Ser His His His Arg Thr Arg Asp Pro Arg Asp Asn Gly Ser Arg 
545                 550                 555                 560 


Ser Gly Asp Leu Pro Tyr Asp Gly Arg Leu Leu Glu Glu Ala Val Arg 
                565                 570                 575     


Lys Lys Gly Ser Glu Glu Arg Arg Arg Pro His Lys Glu Glu Glu Glu 
            580                 585                 590         


Glu Ala Tyr Tyr Pro Pro Ala Pro Pro Pro Tyr Ser Glu Thr Asp Ser 
        595                 600                 605             


Gln Ala Ser Arg Glu Arg Arg Leu Lys Lys Asn Leu Ala Leu Ser Arg 
    610                 615                 620                 


Glu Ser Leu Val Val 
625                 


<210>  8070
<211>  649
<212>  PRT
<213>  Homo Sapiens

<400>  8070

Met Gln Gln Asp Gly Leu Gly Val Gly Thr Arg Asn Gly Ser Gly Lys 
1               5                   10                  15      


Gly Arg Ser Val His Pro Ser Trp Pro Trp Cys Ala Pro Arg Pro Leu 
            20                  25                  30          


Arg Tyr Phe Gly Arg Asp Ala Arg Ala Arg Arg Ala Gln Thr Ala Ala 
        35                  40                  45              


Met Ala Leu Leu Ala Gly Gly Leu Ser Arg Gly Leu Gly Ser His Pro 
    50                  55                  60                  


Ala Ala Ala Gly Arg Asp Ala Val Val Phe Val Trp Leu Leu Leu Ser 
65                  70                  75                  80  


Thr Trp Cys Thr Ala Pro Ala Arg Ala Ile Gln Val Thr Val Ser Asn 
                85                  90                  95      


Pro Tyr His Val Val Ile Leu Phe Gln Pro Val Thr Leu Pro Cys Thr 
            100                 105                 110         


Tyr Gln Met Thr Ser Thr Pro Thr Gln Pro Ile Val Ile Trp Lys Tyr 
        115                 120                 125             


Lys Ser Phe Cys Arg Asp Arg Ile Ala Asp Ala Phe Ser Pro Ala Ser 
    130                 135                 140                 


Val Asp Asn Gln Leu Asn Ala Gln Leu Ala Ala Gly Asn Pro Gly Tyr 
145                 150                 155                 160 


Asn Pro Tyr Val Glu Cys Gln Asp Ser Val Arg Thr Val Arg Val Val 
                165                 170                 175     


Ala Thr Lys Gln Gly Asn Ala Val Thr Leu Gly Asp Tyr Tyr Gln Gly 
            180                 185                 190         


Arg Arg Ile Thr Ile Thr Gly Asn Ala Asp Leu Thr Phe Asp Gln Thr 
        195                 200                 205             


Ala Trp Gly Asp Ser Gly Val Tyr Tyr Cys Ser Val Val Ser Ala Gln 
    210                 215                 220                 


Asp Leu Gln Gly Asn Asn Glu Ala Tyr Ala Glu Leu Ile Val Leu Gly 
225                 230                 235                 240 


Arg Thr Ser Gly Val Ala Glu Leu Leu Pro Gly Phe Gln Ala Gly Pro 
                245                 250                 255     


Ile Glu Asp Trp Leu Phe Val Val Val Val Cys Leu Ala Ala Phe Leu 
            260                 265                 270         


Ile Phe Leu Leu Leu Gly Ile Cys Trp Cys Gln Cys Cys Pro His Thr 
        275                 280                 285             


Cys Cys Cys Tyr Val Arg Cys Pro Cys Cys Pro Asp Lys Cys Cys Cys 
    290                 295                 300                 


Pro Glu Ala Leu Tyr Ala Ala Gly Lys Ala Ala Thr Ser Gly Val Pro 
305                 310                 315                 320 


Ser Ile Tyr Ala Pro Ser Thr Tyr Ala His Leu Ser Pro Ala Lys Thr 
                325                 330                 335     


Pro Pro Pro Pro Ala Met Ile Pro Met Gly Pro Ala Tyr Asn Gly Tyr 
            340                 345                 350         


Pro Gly Gly Tyr Pro Gly Asp Val Asp Arg Ser Ser Ser Ala Gly Gly 
        355                 360                 365             


Gln Gly Ser Tyr Val Pro Leu Leu Arg Asp Thr Asp Ser Ser Val Ala 
    370                 375                 380                 


Ser Glu Val Arg Ser Gly Tyr Arg Ile Gln Ala Ser Gln Gln Asp Asp 
385                 390                 395                 400 


Ser Met Arg Val Leu Tyr Tyr Met Glu Lys Glu Leu Ala Asn Phe Asp 
                405                 410                 415     


Pro Ser Arg Pro Gly Pro Pro Ser Gly Arg Val Glu Arg Ala Met Ser 
            420                 425                 430         


Glu Val Thr Ser Leu His Glu Asp Asp Trp Arg Ser Arg Pro Ser Arg 
        435                 440                 445             


Gly Pro Ala Leu Thr Pro Ile Arg Asp Glu Glu Trp Gly Gly His Ser 
    450                 455                 460                 


Pro Arg Ser Pro Arg Gly Trp Asp Gln Glu Pro Ala Arg Glu Gln Ala 
465                 470                 475                 480 


Gly Gly Gly Trp Arg Ala Arg Arg Pro Arg Ala Arg Ser Val Asp Ala 
                485                 490                 495     


Leu Asp Asp Leu Thr Pro Pro Ser Thr Ala Glu Ser Gly Ser Arg Ser 
            500                 505                 510         


Pro Thr Ser Asn Gly Gly Arg Ser Arg Ala Tyr Met Pro Pro Arg Ser 
        515                 520                 525             


Arg Ser Arg Asp Asp Leu Tyr Asp Gln Asp Asp Ser Arg Asp Phe Pro 
    530                 535                 540                 


Arg Ser Arg Asp Pro His Tyr Asp Asp Phe Arg Ser Arg Glu Arg Pro 
545                 550                 555                 560 


Pro Ala Asp Pro Arg Ser His His His Arg Thr Arg Asp Pro Arg Asp 
                565                 570                 575     


Asn Gly Ser Arg Ser Gly Asp Leu Pro Tyr Asp Gly Arg Leu Leu Glu 
            580                 585                 590         


Glu Ala Val Arg Lys Lys Gly Ser Glu Glu Arg Arg Arg Pro His Lys 
        595                 600                 605             


Glu Glu Glu Glu Glu Ala Tyr Tyr Pro Pro Ala Pro Pro Pro Tyr Ser 
    610                 615                 620                 


Glu Thr Asp Ser Gln Ala Ser Arg Glu Arg Arg Leu Lys Lys Asn Leu 
625                 630                 635                 640 


Ala Leu Ser Arg Glu Ser Leu Val Val 
                645                 


<210>  8071
<211>  649
<212>  PRT
<213>  Homo Sapiens

<400>  8071

Met Gln Gln Asp Gly Leu Gly Val Gly Thr Arg Asn Gly Ser Gly Lys 
1               5                   10                  15      


Gly Arg Ser Val His Pro Ser Trp Pro Trp Cys Ala Pro Arg Pro Leu 
            20                  25                  30          


Arg Tyr Phe Gly Arg Asp Ala Arg Ala Arg Arg Ala Gln Thr Ala Ala 
        35                  40                  45              


Met Ala Leu Leu Ala Gly Gly Leu Ser Arg Gly Leu Gly Ser His Pro 
    50                  55                  60                  


Ala Ala Ala Gly Arg Asp Ala Val Val Phe Val Trp Leu Leu Leu Ser 
65                  70                  75                  80  


Thr Trp Cys Thr Ala Pro Ala Arg Ala Ile Gln Val Thr Val Ser Asn 
                85                  90                  95      


Pro Tyr His Val Val Ile Leu Phe Gln Pro Val Thr Leu Pro Cys Thr 
            100                 105                 110         


Tyr Gln Met Thr Ser Thr Pro Thr Gln Pro Ile Val Ile Trp Lys Tyr 
        115                 120                 125             


Lys Ser Phe Cys Arg Asp Arg Ile Ala Asp Ala Phe Ser Pro Ala Ser 
    130                 135                 140                 


Val Asp Asn Gln Leu Asn Ala Gln Leu Ala Ala Gly Asn Pro Gly Tyr 
145                 150                 155                 160 


Asn Pro Tyr Val Glu Cys Gln Asp Ser Val Arg Thr Val Arg Val Val 
                165                 170                 175     


Ala Thr Lys Gln Gly Asn Ala Val Thr Leu Gly Asp Tyr Tyr Gln Gly 
            180                 185                 190         


Arg Arg Ile Thr Ile Thr Gly Asn Ala Asp Leu Thr Phe Asp Gln Thr 
        195                 200                 205             


Ala Trp Gly Asp Ser Gly Val Tyr Tyr Cys Ser Val Val Ser Ala Gln 
    210                 215                 220                 


Asp Leu Gln Gly Asn Asn Glu Ala Tyr Ala Glu Leu Ile Val Leu Gly 
225                 230                 235                 240 


Arg Thr Ser Gly Val Ala Glu Leu Leu Pro Gly Phe Gln Ala Gly Pro 
                245                 250                 255     


Ile Glu Asp Trp Leu Phe Val Val Val Val Cys Leu Ala Ala Phe Leu 
            260                 265                 270         


Ile Phe Leu Leu Leu Gly Ile Cys Trp Cys Gln Cys Cys Pro His Thr 
        275                 280                 285             


Cys Cys Cys Tyr Val Arg Cys Pro Cys Cys Pro Asp Lys Cys Cys Cys 
    290                 295                 300                 


Pro Glu Ala Leu Tyr Ala Ala Gly Lys Ala Ala Thr Ser Gly Val Pro 
305                 310                 315                 320 


Ser Ile Tyr Ala Pro Ser Thr Tyr Ala His Leu Ser Pro Ala Lys Thr 
                325                 330                 335     


Pro Pro Pro Pro Ala Met Ile Pro Met Gly Pro Ala Tyr Asn Gly Tyr 
            340                 345                 350         


Pro Gly Gly Tyr Pro Gly Asp Val Asp Arg Ser Ser Ser Ala Gly Gly 
        355                 360                 365             


Gln Gly Ser Tyr Val Pro Leu Leu Arg Asp Thr Asp Ser Ser Val Ala 
    370                 375                 380                 


Ser Glu Val Arg Ser Gly Tyr Arg Ile Gln Ala Ser Gln Gln Asp Asp 
385                 390                 395                 400 


Ser Met Arg Val Leu Tyr Tyr Met Glu Lys Glu Leu Ala Asn Phe Asp 
                405                 410                 415     


Pro Ser Arg Pro Gly Pro Pro Ser Gly Arg Val Glu Arg Ala Met Ser 
            420                 425                 430         


Glu Val Thr Ser Leu His Glu Asp Asp Trp Arg Ser Arg Pro Ser Arg 
        435                 440                 445             


Gly Pro Ala Leu Thr Pro Ile Arg Asp Glu Glu Trp Gly Gly His Ser 
    450                 455                 460                 


Pro Arg Ser Pro Arg Gly Trp Asp Gln Glu Pro Ala Arg Glu Gln Ala 
465                 470                 475                 480 


Gly Gly Gly Trp Arg Ala Arg Arg Pro Arg Ala Arg Ser Val Asp Ala 
                485                 490                 495     


Leu Asp Asp Leu Thr Pro Pro Ser Thr Ala Glu Ser Gly Ser Arg Ser 
            500                 505                 510         


Pro Thr Ser Asn Gly Gly Arg Ser Arg Ala Tyr Met Pro Pro Arg Ser 
        515                 520                 525             


Arg Ser Arg Asp Asp Leu Tyr Asp Gln Asp Asp Ser Arg Asp Phe Pro 
    530                 535                 540                 


Arg Ser Arg Asp Pro His Tyr Asp Asp Phe Arg Ser Arg Glu Arg Pro 
545                 550                 555                 560 


Pro Ala Asp Pro Arg Ser His His His Arg Thr Arg Asp Pro Arg Asp 
                565                 570                 575     


Asn Gly Ser Arg Ser Gly Asp Leu Pro Tyr Asp Gly Arg Leu Leu Glu 
            580                 585                 590         


Glu Ala Val Arg Lys Lys Gly Ser Glu Glu Arg Arg Arg Pro His Lys 
        595                 600                 605             


Glu Glu Glu Glu Glu Ala Tyr Tyr Pro Pro Ala Pro Pro Pro Tyr Ser 
    610                 615                 620                 


Glu Thr Asp Ser Gln Ala Ser Arg Glu Arg Arg Leu Lys Lys Asn Leu 
625                 630                 635                 640 


Ala Leu Ser Arg Glu Ser Leu Val Val 
                645                 


<210>  8072
<211>  581
<212>  PRT
<213>  Homo Sapiens

<400>  8072

Met Gln Gln Asp Gly Leu Gly Val Gly Thr Arg Asn Gly Ser Gly Lys 
1               5                   10                  15      


Gly Arg Ser Val His Pro Ser Trp Pro Trp Cys Ala Pro Arg Pro Leu 
            20                  25                  30          


Arg Tyr Phe Gly Arg Asp Ala Arg Ala Arg Arg Ala Gln Thr Ala Ala 
        35                  40                  45              


Met Ala Leu Leu Ala Gly Gly Leu Ser Arg Gly Leu Gly Ser His Pro 
    50                  55                  60                  


Ala Ala Ala Gly Arg Asp Ala Val Val Phe Val Trp Leu Leu Leu Ser 
65                  70                  75                  80  


Thr Trp Cys Thr Ala Pro Ala Arg Ala Ile Gln Val Thr Val Ser Asn 
                85                  90                  95      


Pro Tyr His Val Val Ile Leu Phe Gln Pro Val Thr Leu Pro Cys Thr 
            100                 105                 110         


Tyr Gln Met Thr Ser Thr Pro Thr Gln Pro Ile Val Ile Trp Lys Tyr 
        115                 120                 125             


Lys Ser Phe Cys Arg Asp Arg Ile Ala Asp Ala Phe Ser Pro Ala Ser 
    130                 135                 140                 


Val Asp Asn Gln Leu Asn Ala Gln Leu Ala Ala Gly Asn Pro Gly Tyr 
145                 150                 155                 160 


Asn Pro Tyr Val Glu Cys Gln Asp Ser Val Arg Thr Val Arg Val Val 
                165                 170                 175     


Ala Thr Lys Gln Gly Asn Ala Val Thr Leu Gly Asp Tyr Tyr Gln Gly 
            180                 185                 190         


Arg Arg Ile Thr Ile Thr Gly Asn Ala Asp Leu Thr Phe Asp Gln Thr 
        195                 200                 205             


Ala Trp Gly Asp Ser Gly Val Tyr Tyr Cys Ser Val Val Ser Ala Gln 
    210                 215                 220                 


Asp Leu Gln Gly Asn Asn Glu Ala Tyr Ala Glu Leu Ile Val Leu Val 
225                 230                 235                 240 


Tyr Ala Ala Gly Lys Ala Ala Thr Ser Gly Val Pro Ser Ile Tyr Ala 
                245                 250                 255     


Pro Ser Thr Tyr Ala His Leu Ser Pro Ala Lys Thr Pro Pro Pro Pro 
            260                 265                 270         


Ala Met Ile Pro Met Gly Pro Ala Tyr Asn Gly Tyr Pro Gly Gly Tyr 
        275                 280                 285             


Pro Gly Asp Val Asp Arg Ser Ser Ser Ala Gly Gly Gln Gly Ser Tyr 
    290                 295                 300                 


Val Pro Leu Leu Arg Asp Thr Asp Ser Ser Val Ala Ser Glu Val Arg 
305                 310                 315                 320 


Ser Gly Tyr Arg Ile Gln Ala Ser Gln Gln Asp Asp Ser Met Arg Val 
                325                 330                 335     


Leu Tyr Tyr Met Glu Lys Glu Leu Ala Asn Phe Asp Pro Ser Arg Pro 
            340                 345                 350         


Gly Pro Pro Ser Gly Arg Val Glu Arg Ala Met Ser Glu Val Thr Ser 
        355                 360                 365             


Leu His Glu Asp Asp Trp Arg Ser Arg Pro Ser Arg Gly Pro Ala Leu 
    370                 375                 380                 


Thr Pro Ile Arg Asp Glu Glu Trp Gly Gly His Ser Pro Arg Ser Pro 
385                 390                 395                 400 


Arg Gly Trp Asp Gln Glu Pro Ala Arg Glu Gln Ala Gly Gly Gly Trp 
                405                 410                 415     


Arg Ala Arg Arg Pro Arg Ala Arg Ser Val Asp Ala Leu Asp Asp Leu 
            420                 425                 430         


Thr Pro Pro Ser Thr Ala Glu Ser Gly Ser Arg Ser Pro Thr Ser Asn 
        435                 440                 445             


Gly Gly Arg Ser Arg Ala Tyr Met Pro Pro Arg Ser Arg Ser Arg Asp 
    450                 455                 460                 


Asp Leu Tyr Asp Gln Asp Asp Ser Arg Asp Phe Pro Arg Ser Arg Asp 
465                 470                 475                 480 


Pro His Tyr Asp Asp Phe Arg Ser Arg Glu Arg Pro Pro Ala Asp Pro 
                485                 490                 495     


Arg Ser His His His Arg Thr Arg Asp Pro Arg Asp Asn Gly Ser Arg 
            500                 505                 510         


Ser Gly Asp Leu Pro Tyr Asp Gly Arg Leu Leu Glu Glu Ala Val Arg 
        515                 520                 525             


Lys Lys Gly Ser Glu Glu Arg Arg Arg Pro His Lys Glu Glu Glu Glu 
    530                 535                 540                 


Glu Ala Tyr Tyr Pro Pro Ala Pro Pro Pro Tyr Ser Glu Thr Asp Ser 
545                 550                 555                 560 


Gln Ala Ser Arg Glu Arg Arg Leu Lys Lys Asn Leu Ala Leu Ser Arg 
                565                 570                 575     


Glu Ser Leu Val Val 
            580     


<210>  8073
<211>  51
<212>  PRT
<213>  Homo Sapiens

<400>  8073

Met Gln Gln Asp Gly Leu Gly Val Gly Thr Arg Asn Gly Ser Gly Lys 
1               5                   10                  15      


Gly Arg Ser Val His Pro Ser Trp Pro Trp Cys Ala Pro Arg Pro Leu 
            20                  25                  30          


Ser Ser Cys Gln Gly His Pro Gly Asp Arg Val Gln Pro Leu Pro Arg 
        35                  40                  45              


Gly Asp Pro 
    50      


<210>  8074
<211>  139
<212>  PRT
<213>  Homo Sapiens

<400>  8074

Met Thr Ser Thr Pro Thr Gln Pro Ile Val Ile Trp Lys Tyr Lys Ser 
1               5                   10                  15      


Phe Cys Arg Asp Arg Ile Ala Asp Ala Phe Ser Pro Ala Ser Val Asp 
            20                  25                  30          


Asn Gln Leu Asn Ala Gln Leu Ala Ala Gly Asn Pro Gly Tyr Asn Pro 
        35                  40                  45              


Tyr Val Glu Cys Gln Asp Ser Val Arg Thr Val Arg Val Val Ala Thr 
    50                  55                  60                  


Lys Gln Gly Asn Ala Val Thr Leu Gly Asp Tyr Tyr Gln Gly Arg Arg 
65                  70                  75                  80  


Ile Thr Ile Thr Gly Asn Ala Asp Leu Thr Phe Asp Gln Thr Ala Trp 
                85                  90                  95      


Gly Asp Ser Gly Val Tyr Tyr Cys Ser Val Val Ser Ala Gln Asp Leu 
            100                 105                 110         


Gln Gly Asn Asn Glu Ala Tyr Ala Glu Leu Ile Val Leu Asp Trp Leu 
        115                 120                 125             


Phe Val Val Val Val Cys Leu Ala Ala Phe Leu 
    130                 135                 


<210>  8075
<211>  35
<212>  PRT
<213>  Homo Sapiens

<400>  8075

Met Leu Ser Arg Asn Asp Ala Pro Ser Val Leu Val Pro Gly Pro Gly 
1               5                   10                  15      


Leu Leu Arg Ala Gly Thr Pro Leu Cys Ile Ser Ala Glu Ala Ala Ser 
            20                  25                  30          


Ala Gln Gln 
        35  


<210>  8076
<211>  36
<212>  PRT
<213>  Homo Sapiens

<400>  8076

Met Leu Ser Arg Asn Asp Asp Ile Cys Ile Tyr Gly Gly Leu Gly Leu 
1               5                   10                  15      


Gly Gly Leu Leu Leu Leu Ala Val Val Leu Leu Ser Ala Cys Leu Cys 
            20                  25                  30          


Trp Leu His Arg 
        35      


<210>  8077
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  8077

Met Leu Ser Arg Asn Asp Asp Ile Cys Ile Tyr Gly Gly Leu Gly Leu 
1               5                   10                  15      


Gly Gly Leu Leu Leu Leu Ala Val Val Leu Leu Ser Ala Cys Leu Cys 
            20                  25                  30          


Trp Leu His Arg Arg Ala Pro Ser Val Leu Val Pro Gly Pro Gly Leu 
        35                  40                  45              


Leu Arg Ala Gly Thr Pro Leu Cys Ile Ser Ala Glu Ala Ala Ser Ala 
    50                  55                  60                  


Gln Gln 
65      


<210>  8078
<211>  44
<212>  PRT
<213>  Homo Sapiens

<400>  8078

Met Leu Ser Arg Asn Asp Asp Ile Cys Ile Tyr Gly Gly Leu Gly Leu 
1               5                   10                  15      


Gly Gly Leu Leu Leu Leu Ala Val Val Leu Leu Ser Ala Cys Leu Cys 
            20                  25                  30          


Trp Leu His Arg Arg Glu Ala Ala Ser Ala Gln Gln 
        35                  40                  


<210>  8079
<211>  59
<212>  PRT
<213>  Homo Sapiens

<400>  8079

Met Leu Ser Arg Asn Asp Asp Ile Cys Ile Tyr Gly Gly Leu Gly Leu 
1               5                   10                  15      


Gly Gly Leu Leu Leu Leu Ala Val Val Leu Leu Ser Ala Cys Leu Cys 
            20                  25                  30          


Trp Leu His Arg Arg Gly Pro Gly Leu Leu Arg Ala Gly Thr Pro Leu 
        35                  40                  45              


Cys Ile Ser Ala Glu Ala Ala Ser Ala Gln Gln 
    50                  55                  


<210>  8080
<211>  97
<212>  PRT
<213>  Homo Sapiens

<400>  8080

Met Leu Ser Arg Asn Asp Asp Ile Cys Ile Tyr Gly Gly Leu Gly Leu 
1               5                   10                  15      


Gly Gly Leu Leu Leu Leu Ala Val Val Leu Leu Ser Ala Cys Leu Cys 
            20                  25                  30          


Trp Leu His Arg Arg Val Lys Arg Leu Glu Arg Ser Trp Ala Gln Gly 
        35                  40                  45              


Ser Ser Glu Gln Glu Leu His Tyr Ala Ser Leu Gln Arg Leu Pro Val 
    50                  55                  60                  


Pro Ser Ser Glu Gly Pro Asp Leu Arg Gly Arg Asp Lys Arg Gly Thr 
65                  70                  75                  80  


Lys Glu Asp Pro Arg Ala Asp Tyr Ala Cys Ile Ala Glu Asn Lys Pro 
                85                  90                  95      


Thr 
    


<210>  8081
<211>  104
<212>  PRT
<213>  Homo Sapiens

<400>  8081

Met Leu Ser Arg Asn Asp Asp Ile Cys Ile Tyr Gly Gly Leu Gly Leu 
1               5                   10                  15      


Gly Gly Leu Leu Leu Leu Ala Val Val Leu Leu Ser Ala Cys Leu Cys 
            20                  25                  30          


Trp Leu His Arg Arg Val Lys Arg Leu Glu Arg Ser Trp His Leu Leu 
        35                  40                  45              


Ser Trp Ser Gln Ala Gln Gly Ser Ser Glu Gln Glu Leu His Tyr Ala 
    50                  55                  60                  


Ser Leu Gln Arg Leu Pro Val Pro Ser Ser Glu Gly Pro Asp Leu Arg 
65                  70                  75                  80  


Gly Arg Asp Lys Arg Gly Thr Lys Glu Asp Pro Arg Ala Asp Tyr Ala 
                85                  90                  95      


Cys Ile Ala Glu Asn Lys Pro Thr 
            100                 


<210>  8082
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  8082

Met Leu Ser Arg Asn Asp Asp Ile Cys Ile Tyr Gly Gly Leu Gly Leu 
1               5                   10                  15      


Gly Gly Leu Leu Leu Leu Ala Val Val Leu Leu Ser Ala Cys Leu Cys 
            20                  25                  30          


Trp Leu His Arg Arg Val Lys Arg Leu Glu Arg Ser Trp Arg Leu Pro 
        35                  40                  45              


Val Pro Ser Ser Glu Gly Pro Asp Leu Arg Gly Arg Asp Lys Arg Gly 
    50                  55                  60                  


Thr Lys 
65      


<210>  8083
<211>  13
<212>  PRT
<213>  Homo Sapiens

<400>  8083

Met Leu Ser Arg Asn Asp Glu Ala Ala Ser Ala Gln Gln 
1               5                   10              


<210>  8084
<211>  28
<212>  PRT
<213>  Homo Sapiens

<400>  8084

Met Leu Ser Arg Asn Asp Gly Pro Gly Leu Leu Arg Ala Gly Thr Pro 
1               5                   10                  15      


Leu Cys Ile Ser Ala Glu Ala Ala Ser Ala Gln Gln 
            20                  25              


<210>  8085
<211>  28
<212>  PRT
<213>  Homo Sapiens

<400>  8085

Met Leu Ser Arg Asn Asp Gly Pro Gly Leu Leu Arg Ala Gly Thr Pro 
1               5                   10                  15      


Leu Cys Ile Ser Ala Glu Ala Ala Ser Ala Gln Gln 
            20                  25              


<210>  8086
<211>  28
<212>  PRT
<213>  Homo Sapiens

<400>  8086

Met Leu Ser Arg Asn Asp Gly Pro Gly Leu Leu Arg Ala Gly Thr Pro 
1               5                   10                  15      


Leu Cys Ile Ser Ala Glu Ala Ala Ser Ala Gln Gln 
            20                  25              


<210>  8087
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  8087

Met Leu Ser Arg Asn Asp Val Lys Arg Leu Glu Arg Ser Trp Ala Gln 
1               5                   10                  15      


Gly Ser Ser Glu Gln Glu Leu His Tyr Ala Ser Leu Gln Arg Leu Pro 
            20                  25                  30          


Val Pro Ser Ser Glu Gly Pro Asp Leu Arg Gly Arg Asp Lys Arg Gly 
        35                  40                  45              


Thr Lys Glu Asp Pro Arg Ala Asp Tyr Ala Cys Ile Ala Glu Asn Lys 
    50                  55                  60                  


Pro Thr 
65      


<210>  8088
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  8088

Met Leu Ser Arg Asn Asp Val Lys Arg Leu Glu Arg Ser Trp Ala Gln 
1               5                   10                  15      


Gly Ser Ser Glu Gln Glu Leu His Tyr Ala Ser Leu Gln Arg Leu Pro 
            20                  25                  30          


Val Pro Ser Ser Glu Gly Pro Asp Leu Arg Gly Arg Asp Lys Arg Gly 
        35                  40                  45              


Thr Lys Glu Asp Pro Arg Ala Asp Tyr Ala Cys Ile Ala Glu Asn Lys 
    50                  55                  60                  


Pro Thr 
65      


<210>  8089
<211>  73
<212>  PRT
<213>  Homo Sapiens

<400>  8089

Met Leu Ser Arg Asn Asp Val Lys Arg Leu Glu Arg Ser Trp His Leu 
1               5                   10                  15      


Leu Ser Trp Ser Gln Ala Gln Gly Ser Ser Glu Gln Glu Leu His Tyr 
            20                  25                  30          


Ala Ser Leu Gln Arg Leu Pro Val Pro Ser Ser Glu Gly Pro Asp Leu 
        35                  40                  45              


Arg Gly Arg Asp Lys Arg Gly Thr Lys Glu Asp Pro Arg Ala Asp Tyr 
    50                  55                  60                  


Ala Cys Ile Ala Glu Asn Lys Pro Thr 
65                  70              


<210>  8090
<211>  51
<212>  PRT
<213>  Homo Sapiens

<400>  8090

Met Leu Ser Arg Asn Asp Val Lys Arg Leu Glu Arg Ser Trp Arg Leu 
1               5                   10                  15      


Pro Val Pro Ser Ser Glu Gly Pro Asp Leu Arg Gly Arg Asp Lys Arg 
            20                  25                  30          


Gly Thr Lys Glu Asp Pro Arg Ala Asp Tyr Ala Cys Ile Ala Glu Asn 
        35                  40                  45              


Lys Pro Thr 
    50      


<210>  8091
<211>  60
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8091

Xaa Asp Ile Cys Ile Tyr Gly Gly Leu Gly Leu Gly Gly Leu Leu Leu 
1               5                   10                  15      


Leu Ala Val Val Leu Leu Ser Ala Cys Leu Cys Trp Leu His Arg Arg 
            20                  25                  30          


Glu Ala Gly Glu Glu Leu Gly Pro Gly Leu Leu Arg Ala Gly Thr Pro 
        35                  40                  45              


Leu Cys Ile Ser Ala Glu Ala Ala Ser Ala Gln Gln 
    50                  55                  60  


<210>  8092
<211>  35
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8092

Xaa Gly Gly Leu Leu Leu Leu Ala Val Val Leu Leu Ser Ala Cys Leu 
1               5                   10                  15      


Cys Trp Leu His Arg Arg Glu Ala Gly Glu Glu Leu Glu Ala Ala Ser 
            20                  25                  30          


Ala Gln Gln 
        35  


<210>  8093
<211>  205
<212>  PRT
<213>  Homo Sapiens

<400>  8093

Met Thr Pro Pro Glu Arg Leu Phe Leu Pro Arg Val Cys Gly Thr Thr 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Gly Leu Leu Leu Val Leu Leu Pro Gly Ala 
            20                  25                  30          


Gln Gly Leu Pro Gly Val Gly Leu Thr Pro Ser Ala Ala Gln Thr Ala 
        35                  40                  45              


Arg Gln His Pro Lys Met His Leu Ala His Ser Thr Leu Lys Pro Ala 
    50                  55                  60                  


Ala His Leu Ile Gly Asp Pro Ser Lys Gln Asn Ser Leu Leu Trp Arg 
65                  70                  75                  80  


Ala Asn Thr Asp Arg Ala Phe Leu Gln Asp Gly Phe Ser Leu Ser Asn 
                85                  90                  95      


Asn Ser Leu Leu Val Pro Thr Ser Gly Ile Tyr Phe Val Tyr Ser Gln 
            100                 105                 110         


Val Val Phe Ser Gly Lys Ala Tyr Ser Pro Lys Ala Thr Ser Ser Pro 
        115                 120                 125             


Leu Tyr Leu Ala His Glu Val Gln Leu Phe Ser Ser Gln Tyr Pro Phe 
    130                 135                 140                 


His Val Pro Leu Leu Ser Ser Gln Lys Met Val Tyr Pro Gly Leu Gln 
145                 150                 155                 160 


Glu Pro Trp Leu His Ser Met Tyr His Gly Ala Ala Phe Gln Leu Thr 
                165                 170                 175     


Gln Gly Asp Gln Leu Ser Thr His Thr Asp Gly Ile Pro His Leu Val 
            180                 185                 190         


Leu Ser Pro Ser Thr Val Phe Phe Gly Ala Phe Ala Leu 
        195                 200                 205 


<210>  8094
<211>  205
<212>  PRT
<213>  Homo Sapiens

<400>  8094

Met Thr Pro Pro Glu Arg Leu Phe Leu Pro Arg Val Cys Gly Thr Thr 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Gly Leu Leu Leu Val Leu Leu Pro Gly Ala 
            20                  25                  30          


Gln Gly Leu Pro Gly Val Gly Leu Thr Pro Ser Ala Ala Gln Thr Ala 
        35                  40                  45              


Arg Gln His Pro Lys Met His Leu Ala His Ser Thr Leu Lys Pro Ala 
    50                  55                  60                  


Ala His Leu Ile Gly Asp Pro Ser Lys Gln Asn Ser Leu Leu Trp Arg 
65                  70                  75                  80  


Ala Asn Thr Asp Arg Ala Phe Leu Gln Asp Gly Phe Ser Leu Ser Asn 
                85                  90                  95      


Asn Ser Leu Leu Val Pro Thr Ser Gly Ile Tyr Phe Val Tyr Ser Gln 
            100                 105                 110         


Val Val Phe Ser Gly Lys Ala Tyr Ser Pro Lys Ala Thr Ser Ser Pro 
        115                 120                 125             


Leu Tyr Leu Ala His Glu Val Gln Leu Phe Ser Ser Gln Tyr Pro Phe 
    130                 135                 140                 


His Val Pro Leu Leu Ser Ser Gln Lys Met Val Tyr Pro Gly Leu Gln 
145                 150                 155                 160 


Glu Pro Trp Leu His Ser Met Tyr His Gly Ala Ala Phe Gln Leu Thr 
                165                 170                 175     


Gln Gly Asp Gln Leu Ser Thr His Thr Asp Gly Ile Pro His Leu Val 
            180                 185                 190         


Leu Ser Pro Ser Thr Val Phe Phe Gly Ala Phe Ala Leu 
        195                 200                 205 


<210>  8095
<211>  270
<212>  PRT
<213>  Homo Sapiens

<400>  8095

Glu Cys Gln His Arg His Leu Cys Ala His Gly Gln Cys Arg Asn Thr 
1               5                   10                  15      


Glu Gly Ser Phe Gln Cys Val Cys Asp Gln Gly Tyr Arg Ala Ser Gly 
            20                  25                  30          


Leu Gly Asp His Cys Glu Asp Ile Asn Glu Cys Leu Glu Asp Lys Ser 
        35                  40                  45              


Val Cys Gln Arg Gly Asp Cys Ile Asn Thr Ala Gly Ser Tyr Asp Cys 
    50                  55                  60                  


Thr Cys Pro Asp Gly Phe Gln Leu Asp Asp Asn Lys Thr Cys Gln Asp 
65                  70                  75                  80  


Ile Asn Glu Cys Glu His Pro Gly Leu Cys Gly Pro Gln Gly Glu Cys 
                85                  90                  95      


Leu Asn Thr Glu Gly Ser Phe His Cys Val Cys Gln Gln Gly Phe Ser 
            100                 105                 110         


Ile Ser Ala Asp Gly Arg Thr Cys Glu Asp Val Asn Glu Cys Glu Leu 
        115                 120                 125             


Leu Ser Gly Val Cys Gly Glu Ala Phe Cys Glu Asn Val Glu Gly Ser 
    130                 135                 140                 


Phe Leu Cys Val Cys Ala Asp Glu Asn Gln Glu Tyr Ser Pro Met Thr 
145                 150                 155                 160 


Gly Gln Cys Arg Ser Arg Thr Ser Thr Asp Leu Asp Val Asp Val Asp 
                165                 170                 175     


Gln Pro Lys Glu Glu Lys Lys Glu Cys Tyr Tyr Asn Leu Asn Asp Ala 
            180                 185                 190         


Ser Leu Cys Asp Asn Val Leu Ala Pro Asn Val Thr Lys Gln Glu Cys 
        195                 200                 205             


Cys Cys Thr Ser Gly Val Gly Trp Gly Asp Asn Cys Glu Ile Phe Pro 
    210                 215                 220                 


Cys Pro Val Leu Gly Thr Ala Glu Phe Thr Glu Met Cys Pro Lys Gly 
225                 230                 235                 240 


Lys Gly Phe Val Pro Ala Gly Glu Ser Ser Ser Glu Ala Gly Gly Glu 
                245                 250                 255     


Asn Tyr Lys Asp Ala Asp Glu Cys Leu Leu Phe Gly Gln Glu 
            260                 265                 270 


<210>  8096
<211>  1721
<212>  PRT
<213>  Homo Sapiens

<400>  8096

Met Ala Gly Ala Trp Leu Arg Trp Gly Leu Leu Leu Trp Ala Gly Leu 
1               5                   10                  15      


Leu Ala Ser Ser Ala His Gly Arg Leu Arg Arg Ile Thr Tyr Val Val 
            20                  25                  30          


His Pro Gly Pro Gly Leu Ala Ala Gly Ala Leu Pro Leu Ser Gly Pro 
        35                  40                  45              


Pro Arg Ser Arg Thr Phe Asn Val Ala Leu Asn Ala Arg Tyr Ser Arg 
    50                  55                  60                  


Ser Ser Ala Ala Ala Gly Ala Pro Ser Arg Ala Ser Pro Gly Val Pro 
65                  70                  75                  80  


Ser Glu Arg Thr Arg Arg Thr Ser Lys Pro Gly Gly Ala Ala Leu Gln 
                85                  90                  95      


Gly Leu Arg Pro Pro Pro Pro Pro Pro Pro Glu Pro Ala Arg Pro Ala 
            100                 105                 110         


Val Pro Gly Gly Gln Leu His Pro Asn Pro Gly Gly His Pro Ala Ala 
        115                 120                 125             


Ala Pro Phe Thr Lys Gln Gly Arg Gln Val Val Arg Ser Lys Val Pro 
    130                 135                 140                 


Gln Glu Thr Gln Ser Gly Gly Gly Ser Arg Leu Gln Val His Gln Lys 
145                 150                 155                 160 


Gln Gln Leu Gln Gly Val Asn Val Cys Gly Gly Arg Cys Cys His Gly 
                165                 170                 175     


Trp Ser Lys Ala Pro Gly Ser Gln Arg Cys Thr Lys Pro Ser Cys Val 
            180                 185                 190         


Pro Pro Cys Gln Asn Gly Gly Met Cys Leu Arg Pro Gln Leu Cys Val 
        195                 200                 205             


Cys Lys Pro Gly Thr Lys Gly Lys Ala Cys Glu Thr Ile Ala Ala Gln 
    210                 215                 220                 


Asp Thr Ser Ser Pro Val Phe Gly Gly Gln Ser Pro Gly Ala Ala Ser 
225                 230                 235                 240 


Ser Trp Gly Pro Pro Glu Gln Ala Ala Lys His Thr Ser Ser Lys Lys 
                245                 250                 255     


Ala Asp Thr Leu Pro Arg Val Ser Pro Val Ala Gln Met Thr Leu Thr 
            260                 265                 270         


Leu Lys Pro Lys Pro Ser Val Gly Leu Pro Gln Gln Ile His Ser Gln 
        275                 280                 285             


Val Thr Pro Leu Ser Ser Gln Ser Val Val Ile His His Gly Gln Thr 
    290                 295                 300                 


Gln Glu Tyr Val Leu Lys Pro Lys Tyr Phe Pro Ala Gln Lys Gly Ile 
305                 310                 315                 320 


Ser Gly Glu Gln Ser Thr Glu Gly Ser Phe Pro Leu Arg Tyr Val Gln 
                325                 330                 335     


Asp Gln Val Ala Ala Pro Phe Gln Leu Ser Asn His Thr Gly Arg Ile 
            340                 345                 350         


Lys Val Val Phe Thr Pro Ser Ile Cys Lys Val Thr Cys Thr Lys Gly 
        355                 360                 365             


Ser Cys Gln Asn Ser Cys Glu Lys Gly Asn Thr Thr Thr Leu Ile Ser 
    370                 375                 380                 


Glu Asn Gly His Ala Ala Asp Thr Leu Thr Ala Thr Asn Phe Arg Val 
385                 390                 395                 400 


Val Ile Cys His Leu Pro Cys Met Asn Gly Gly Gln Cys Ser Ser Arg 
                405                 410                 415     


Asp Lys Cys Gln Cys Pro Pro Asn Phe Thr Gly Lys Leu Cys Gln Ile 
            420                 425                 430         


Pro Val His Gly Ala Ser Val Pro Lys Leu Tyr Gln His Ser Gln Gln 
        435                 440                 445             


Pro Gly Lys Ala Leu Gly Thr His Val Ile His Ser Thr His Thr Leu 
    450                 455                 460                 


Pro Leu Thr Val Thr Ser Gln Gln Gly Val Lys Val Lys Phe Pro Pro 
465                 470                 475                 480 


Asn Ile Val Asn Ile His Val Lys His Pro Pro Glu Ala Ser Val Gln 
                485                 490                 495     


Ile His Gln Val Ser Arg Ile Asp Gly Pro Thr Gly Gln Lys Thr Lys 
            500                 505                 510         


Glu Ala Gln Pro Gly Gln Ser Gln Val Ser Tyr Gln Gly Leu Pro Val 
        515                 520                 525             


Gln Lys Thr Gln Thr Ile His Ser Thr Tyr Ser His Gln Gln Val Ile 
    530                 535                 540                 


Pro His Val Tyr Pro Val Ala Ala Lys Thr Gln Leu Gly Arg Cys Phe 
545                 550                 555                 560 


Gln Glu Thr Ile Gly Ser Gln Cys Gly Lys Ala Leu Pro Gly Leu Ser 
                565                 570                 575     


Lys Gln Glu Asp Cys Cys Gly Thr Val Gly Thr Ser Trp Gly Phe Asn 
            580                 585                 590         


Lys Cys Gln Lys Cys Pro Lys Lys Pro Ser Tyr His Gly Tyr Asn Gln 
        595                 600                 605             


Met Met Glu Cys Leu Pro Gly Tyr Lys Arg Val Asn Asn Thr Phe Cys 
    610                 615                 620                 


Gln Asp Ile Asn Glu Cys Gln Leu Gln Gly Val Cys Pro Asn Gly Glu 
625                 630                 635                 640 


Cys Leu Asn Thr Met Gly Ser Tyr Arg Cys Thr Cys Lys Ile Gly Phe 
                645                 650                 655     


Gly Pro Asp Pro Thr Phe Ser Ser Cys Val Pro Asp Pro Pro Val Ile 
            660                 665                 670         


Ser Glu Glu Lys Gly Pro Cys Tyr Arg Leu Val Ser Ser Gly Arg Gln 
        675                 680                 685             


Cys Met His Pro Leu Ser Val His Leu Thr Lys Gln Leu Cys Cys Cys 
    690                 695                 700                 


Ser Val Gly Lys Ala Trp Gly Pro His Cys Glu Lys Cys Pro Leu Pro 
705                 710                 715                 720 


Gly Thr Ala Ala Phe Lys Glu Ile Cys Pro Gly Gly Met Gly Tyr Thr 
                725                 730                 735     


Val Ser Gly Val His Arg Arg Arg Pro Ile His His His Val Gly Lys 
            740                 745                 750         


Gly Pro Val Phe Val Lys Pro Lys Asn Thr Gln Pro Val Ala Lys Ser 
        755                 760                 765             


Thr His Pro Pro Pro Leu Pro Ala Lys Glu Glu Pro Val Glu Ala Leu 
    770                 775                 780                 


Thr Phe Ser Arg Glu His Gly Pro Gly Val Ala Glu Pro Glu Val Ala 
785                 790                 795                 800 


Thr Ala Pro Pro Glu Lys Glu Ile Pro Ser Leu Asp Gln Glu Lys Thr 
                805                 810                 815     


Lys Leu Glu Pro Gly Gln Pro Gln Leu Ser Pro Gly Ile Ser Thr Ile 
            820                 825                 830         


His Leu His Pro Gln Phe Pro Val Val Ile Glu Lys Thr Ser Pro Pro 
        835                 840                 845             


Val Pro Val Glu Val Ala Pro Glu Ala Ser Thr Ser Ser Ala Ser Gln 
    850                 855                 860                 


Val Ile Ala Pro Thr Gln Val Thr Glu Ile Asn Glu Cys Thr Val Asn 
865                 870                 875                 880 


Pro Asp Ile Cys Gly Ala Gly His Cys Ile Asn Leu Pro Val Arg Tyr 
                885                 890                 895     


Thr Cys Ile Cys Tyr Glu Gly Tyr Arg Phe Ser Glu Gln Gln Arg Lys 
            900                 905                 910         


Cys Val Asp Ile Asp Glu Cys Thr Gln Val Gln His Leu Cys Ser Gln 
        915                 920                 925             


Gly Arg Cys Glu Asn Thr Glu Gly Ser Phe Leu Cys Ile Cys Pro Ala 
    930                 935                 940                 


Gly Phe Met Ala Ser Glu Glu Gly Thr Asn Cys Ile Asp Val Asp Glu 
945                 950                 955                 960 


Cys Leu Arg Pro Asp Val Cys Gly Glu Gly His Cys Val Asn Thr Val 
                965                 970                 975     


Gly Ala Phe Arg Cys Glu Tyr Cys Asp Ser Gly Tyr Arg Met Thr Gln 
            980                 985                 990         


Arg Gly Arg Cys Glu Asp Ile Asp  Glu Cys Leu Asn Pro  Ser Thr Cys 
        995                 1000                 1005             


Pro Asp  Glu Gln Cys Val Asn  Ser Pro Gly Ser Tyr  Gln Cys Val 
    1010                 1015                 1020             


Pro Cys  Thr Glu Gly Phe Arg  Gly Trp Asn Gly Gln  Cys Leu Asp 
    1025                 1030                 1035             


Val Asp  Glu Cys Leu Glu Pro  Asn Val Cys Ala Asn  Gly Asp Cys 
    1040                 1045                 1050             


Ser Asn  Leu Glu Gly Ser Tyr  Met Cys Ser Cys His  Lys Gly Tyr 
    1055                 1060                 1065             


Thr Arg  Thr Pro Asp His Lys  His Cys Arg Asp Ile  Asp Glu Cys 
    1070                 1075                 1080             


Gln Gln  Gly Asn Leu Cys Val  Asn Gly Gln Cys Lys  Asn Thr Glu 
    1085                 1090                 1095             


Gly Ser  Phe Arg Cys Thr Cys  Gly Gln Gly Tyr Gln  Leu Ser Ala 
    1100                 1105                 1110             


Ala Lys  Asp Gln Cys Glu Asp  Ile Asp Glu Cys Gln  His Arg His 
    1115                 1120                 1125             


Leu Cys  Ala His Gly Gln Cys  Arg Asn Thr Glu Gly  Ser Phe Gln 
    1130                 1135                 1140             


Cys Val  Cys Asp Gln Gly Tyr  Arg Ala Ser Gly Leu  Gly Asp His 
    1145                 1150                 1155             


Cys Glu  Asp Ile Asn Glu Cys  Leu Glu Asp Lys Ser  Val Cys Gln 
    1160                 1165                 1170             


Arg Gly  Asp Cys Ile Asn Thr  Ala Gly Ser Tyr Asp  Cys Thr Cys 
    1175                 1180                 1185             


Pro Asp  Gly Phe Gln Leu Asp  Asp Asn Lys Thr Cys  Gln Asp Ile 
    1190                 1195                 1200             


Asn Glu  Cys Glu His Pro Gly  Leu Cys Gly Pro Gln  Gly Glu Cys 
    1205                 1210                 1215             


Leu Asn  Thr Glu Gly Ser Phe  His Cys Val Cys Gln  Gln Gly Phe 
    1220                 1225                 1230             


Ser Ile  Ser Ala Asp Gly Arg  Thr Cys Glu Asp Ile  Asp Glu Cys 
    1235                 1240                 1245             


Val Asn  Asn Thr Val Cys Asp  Ser His Gly Phe Cys  Asp Asn Thr 
    1250                 1255                 1260             


Ala Gly  Ser Phe Arg Cys Leu  Cys Tyr Gln Gly Phe  Gln Ala Pro 
    1265                 1270                 1275             


Gln Asp  Gly Gln Gly Cys Val  Asp Val Asn Glu Cys  Glu Leu Leu 
    1280                 1285                 1290             


Ser Gly  Val Cys Gly Glu Ala  Phe Cys Glu Asn Val  Glu Gly Ser 
    1295                 1300                 1305             


Phe Leu  Cys Val Cys Ala Asp  Glu Asn Gln Glu Tyr  Ser Pro Met 
    1310                 1315                 1320             


Thr Gly  Gln Cys Arg Ser Arg  Thr Ser Thr Asp Leu  Asp Val Asp 
    1325                 1330                 1335             


Val Asp  Gln Pro Lys Glu Glu  Lys Lys Glu Cys Tyr  Tyr Asn Leu 
    1340                 1345                 1350             


Asn Asp  Ala Ser Leu Cys Asp  Asn Val Leu Ala Pro  Asn Val Thr 
    1355                 1360                 1365             


Lys Gln  Glu Cys Cys Cys Thr  Ser Gly Val Gly Trp  Gly Asp Asn 
    1370                 1375                 1380             


Cys Glu  Ile Phe Pro Cys Pro  Val Leu Gly Thr Ala  Glu Phe Thr 
    1385                 1390                 1395             


Glu Met  Cys Pro Lys Gly Lys  Gly Phe Val Pro Ala  Gly Glu Ser 
    1400                 1405                 1410             


Ser Ser  Glu Ala Gly Gly Glu  Asn Tyr Lys Asp Ala  Asp Glu Cys 
    1415                 1420                 1425             


Leu Leu  Phe Gly Gln Glu Ile  Cys Lys Asn Gly Phe  Cys Leu Asn 
    1430                 1435                 1440             


Thr Arg  Pro Gly Tyr Glu Cys  Tyr Cys Lys Gln Gly  Thr Tyr Tyr 
    1445                 1450                 1455             


Asp Pro  Val Lys Leu Gln Cys  Phe Asp Met Asp Glu  Cys Gln Asp 
    1460                 1465                 1470             


Pro Ser  Ser Cys Ile Asp Gly  Gln Cys Val Asn Thr  Glu Gly Ser 
    1475                 1480                 1485             


Tyr Asn  Cys Phe Cys Thr His  Pro Met Val Leu Asp  Ala Ser Glu 
    1490                 1495                 1500             


Lys Arg  Cys Ile Arg Pro Ala  Glu Ser Asn Glu Gln  Ile Glu Glu 
    1505                 1510                 1515             


Thr Asp  Val Tyr Gln Asp Leu  Cys Trp Glu His Leu  Ser Asp Glu 
    1520                 1525                 1530             


Tyr Val  Cys Ser Arg Pro Leu  Val Gly Lys Gln Thr  Thr Tyr Thr 
    1535                 1540                 1545             


Glu Cys  Cys Cys Leu Tyr Gly  Glu Ala Trp Gly Met  Gln Cys Ala 
    1550                 1555                 1560             


Leu Cys  Pro Leu Lys Asp Ser  Asp Asp Tyr Ala Gln  Leu Cys Asn 
    1565                 1570                 1575             


Ile Pro  Val Thr Gly Arg Arg  Gln Pro Tyr Gly Arg  Asp Ala Leu 
    1580                 1585                 1590             


Val Asp  Phe Ser Glu Gln Tyr  Thr Pro Glu Ala Asp  Pro Tyr Phe 
    1595                 1600                 1605             


Ile Gln  Asp Arg Phe Leu Asn  Ser Phe Glu Glu Leu  Gln Ala Glu 
    1610                 1615                 1620             


Glu Cys  Gly Ile Leu Asn Gly  Cys Glu Asn Gly Arg  Cys Val Arg 
    1625                 1630                 1635             


Val Gln  Glu Gly Tyr Thr Cys  Asp Cys Phe Asp Gly  Tyr His Leu 
    1640                 1645                 1650             


Asp Thr  Ala Lys Met Thr Cys  Val Asp Val Asn Glu  Cys Asp Glu 
    1655                 1660                 1665             


Leu Asn  Asn Arg Met Ser Leu  Cys Lys Asn Ala Lys  Cys Ile Asn 
    1670                 1675                 1680             


Thr Asp  Gly Ser Tyr Lys Cys  Leu Cys Leu Pro Gly  Tyr Val Pro 
    1685                 1690                 1695             


Ser Asp  Lys Pro Asn Tyr Cys  Thr Pro Leu Asn Thr  Ala Leu Asn 
    1700                 1705                 1710             


Leu Glu  Lys Asp Ser Asp Leu  Glu 
    1715                 1720     


<210>  8097
<211>  1395
<212>  PRT
<213>  Homo Sapiens

<400>  8097

Met Asp Thr Lys Leu Met Cys Leu Leu Phe Phe Phe Ser Leu Pro Pro 
1               5                   10                  15      


Leu Leu Val Ser Asn His Thr Gly Arg Ile Lys Val Val Phe Thr Pro 
            20                  25                  30          


Ser Ile Cys Lys Val Thr Cys Thr Lys Gly Ser Cys Gln Asn Ser Cys 
        35                  40                  45              


Glu Lys Gly Asn Thr Thr Thr Leu Ile Ser Glu Asn Gly His Ala Ala 
    50                  55                  60                  


Asp Thr Leu Thr Ala Thr Asn Phe Arg Val Val Ile Cys His Leu Pro 
65                  70                  75                  80  


Cys Met Asn Gly Gly Gln Cys Ser Ser Arg Asp Lys Cys Gln Cys Pro 
                85                  90                  95      


Pro Asn Phe Thr Gly Lys Leu Cys Gln Ile Pro Val His Gly Ala Ser 
            100                 105                 110         


Val Pro Lys Leu Tyr Gln His Ser Gln Gln Pro Gly Lys Ala Leu Gly 
        115                 120                 125             


Thr His Val Ile His Ser Thr His Thr Leu Pro Leu Thr Val Thr Ser 
    130                 135                 140                 


Gln Gln Gly Val Lys Val Lys Phe Pro Pro Asn Ile Val Asn Ile His 
145                 150                 155                 160 


Val Lys His Pro Pro Glu Ala Ser Val Gln Ile His Gln Val Ser Arg 
                165                 170                 175     


Ile Asp Gly Pro Thr Gly Gln Lys Thr Lys Glu Ala Gln Pro Gly Gln 
            180                 185                 190         


Ser Gln Val Ser Tyr Gln Gly Leu Pro Val Gln Lys Thr Gln Thr Ile 
        195                 200                 205             


His Ser Thr Tyr Ser His Gln Gln Val Ile Pro His Val Tyr Pro Val 
    210                 215                 220                 


Ala Ala Lys Thr Gln Leu Gly Arg Cys Phe Gln Glu Thr Ile Gly Ser 
225                 230                 235                 240 


Gln Cys Gly Lys Ala Leu Pro Gly Leu Ser Lys Gln Glu Asp Cys Cys 
                245                 250                 255     


Gly Thr Val Gly Thr Ser Trp Gly Phe Asn Lys Cys Gln Lys Cys Pro 
            260                 265                 270         


Lys Lys Pro Ser Tyr His Gly Tyr Asn Gln Met Met Glu Cys Leu Pro 
        275                 280                 285             


Gly Tyr Lys Arg Val Asn Asn Thr Phe Cys Gln Asp Ile Asn Glu Cys 
    290                 295                 300                 


Gln Leu Gln Gly Val Cys Pro Asn Gly Glu Cys Leu Asn Thr Met Gly 
305                 310                 315                 320 


Ser Tyr Arg Cys Thr Cys Lys Ile Gly Phe Gly Pro Asp Pro Thr Phe 
                325                 330                 335     


Ser Ser Cys Val Pro Asp Pro Pro Val Ile Ser Glu Glu Lys Gly Pro 
            340                 345                 350         


Cys Tyr Arg Leu Val Ser Ser Gly Arg Gln Cys Met His Pro Leu Ser 
        355                 360                 365             


Val His Leu Thr Lys Gln Leu Cys Cys Cys Ser Val Gly Lys Ala Trp 
    370                 375                 380                 


Gly Pro His Cys Glu Lys Cys Pro Leu Pro Gly Thr Ala Ala Phe Lys 
385                 390                 395                 400 


Glu Ile Cys Pro Gly Gly Met Gly Tyr Thr Val Ser Gly Val His Arg 
                405                 410                 415     


Arg Arg Pro Ile His His His Val Gly Lys Gly Pro Val Phe Val Lys 
            420                 425                 430         


Pro Lys Asn Thr Gln Pro Val Ala Lys Ser Thr His Pro Pro Pro Leu 
        435                 440                 445             


Pro Ala Lys Glu Glu Pro Val Glu Ala Leu Thr Phe Ser Arg Glu His 
    450                 455                 460                 


Gly Pro Gly Val Ala Glu Pro Glu Val Ala Thr Ala Pro Pro Glu Lys 
465                 470                 475                 480 


Glu Ile Pro Ser Leu Asp Gln Glu Lys Thr Lys Leu Glu Pro Gly Gln 
                485                 490                 495     


Pro Gln Leu Ser Pro Gly Ile Ser Thr Ile His Leu His Pro Gln Phe 
            500                 505                 510         


Pro Val Val Ile Glu Lys Thr Ser Pro Pro Val Pro Val Glu Val Ala 
        515                 520                 525             


Pro Glu Ala Ser Thr Ser Ser Ala Ser Gln Val Ile Ala Pro Thr Gln 
    530                 535                 540                 


Val Thr Glu Ile Asn Glu Cys Thr Val Asn Pro Asp Ile Cys Gly Ala 
545                 550                 555                 560 


Gly His Cys Ile Asn Leu Pro Val Arg Tyr Thr Cys Ile Cys Tyr Glu 
                565                 570                 575     


Gly Tyr Arg Phe Ser Glu Gln Gln Arg Lys Cys Val Asp Ile Asp Glu 
            580                 585                 590         


Cys Thr Gln Val Gln His Leu Cys Ser Gln Gly Arg Cys Glu Asn Thr 
        595                 600                 605             


Glu Gly Ser Phe Leu Cys Ile Cys Pro Ala Gly Phe Met Ala Ser Glu 
    610                 615                 620                 


Glu Gly Thr Asn Cys Ile Asp Val Asp Glu Cys Leu Arg Pro Asp Val 
625                 630                 635                 640 


Cys Gly Glu Gly His Cys Val Asn Thr Val Gly Ala Phe Arg Cys Glu 
                645                 650                 655     


Tyr Cys Asp Ser Gly Tyr Arg Met Thr Gln Arg Gly Arg Cys Glu Asp 
            660                 665                 670         


Ile Asp Glu Cys Leu Asn Pro Ser Thr Cys Pro Asp Glu Gln Cys Val 
        675                 680                 685             


Asn Ser Pro Gly Ser Tyr Gln Cys Val Pro Cys Thr Glu Gly Phe Arg 
    690                 695                 700                 


Gly Trp Asn Gly Gln Cys Leu Asp Val Asp Glu Cys Leu Glu Pro Asn 
705                 710                 715                 720 


Val Cys Ala Asn Gly Asp Cys Ser Asn Leu Glu Gly Ser Tyr Met Cys 
                725                 730                 735     


Ser Cys His Lys Gly Tyr Thr Arg Thr Pro Asp His Lys His Cys Arg 
            740                 745                 750         


Asp Ile Asp Glu Cys Gln Gln Gly Asn Leu Cys Val Asn Gly Gln Cys 
        755                 760                 765             


Lys Asn Thr Glu Gly Ser Phe Arg Cys Thr Cys Gly Gln Gly Tyr Gln 
    770                 775                 780                 


Leu Ser Ala Ala Lys Asp Gln Cys Glu Asp Ile Asp Glu Cys Gln His 
785                 790                 795                 800 


Arg His Leu Cys Ala His Gly Gln Cys Arg Asn Thr Glu Gly Ser Phe 
                805                 810                 815     


Gln Cys Val Cys Asp Gln Gly Tyr Arg Ala Ser Gly Leu Gly Asp His 
            820                 825                 830         


Cys Glu Asp Ile Asn Glu Cys Leu Glu Asp Lys Ser Val Cys Gln Arg 
        835                 840                 845             


Gly Asp Cys Ile Asn Thr Ala Gly Ser Tyr Asp Cys Thr Cys Pro Asp 
    850                 855                 860                 


Gly Phe Gln Leu Asp Asp Asn Lys Thr Cys Gln Asp Ile Asn Glu Cys 
865                 870                 875                 880 


Glu His Pro Gly Leu Cys Gly Pro Gln Gly Glu Cys Leu Asn Thr Glu 
                885                 890                 895     


Gly Ser Phe His Cys Val Cys Gln Gln Gly Phe Ser Ile Ser Ala Asp 
            900                 905                 910         


Gly Arg Thr Cys Glu Asp Ile Asp Glu Cys Val Asn Asn Thr Val Cys 
        915                 920                 925             


Asp Ser His Gly Phe Cys Asp Asn Thr Ala Gly Ser Phe Arg Cys Leu 
    930                 935                 940                 


Cys Tyr Gln Gly Phe Gln Ala Pro Gln Asp Gly Gln Gly Cys Val Asp 
945                 950                 955                 960 


Val Asn Glu Cys Glu Leu Leu Ser Gly Val Cys Gly Glu Ala Phe Cys 
                965                 970                 975     


Glu Asn Val Glu Gly Ser Phe Leu Cys Val Cys Ala Asp Glu Asn Gln 
            980                 985                 990         


Glu Tyr Ser Pro Met Thr Gly Gln  Cys Arg Ser Arg Thr  Ser Thr Asp 
        995                 1000                 1005             


Leu Asp  Val Asp Val Asp Gln  Pro Lys Glu Glu Lys  Lys Glu Cys 
    1010                 1015                 1020             


Tyr Tyr  Asn Leu Asn Asp Ala  Ser Leu Cys Asp Asn  Val Leu Ala 
    1025                 1030                 1035             


Pro Asn  Val Thr Lys Gln Glu  Cys Cys Cys Thr Ser  Gly Val Gly 
    1040                 1045                 1050             


Trp Gly  Asp Asn Cys Glu Ile  Phe Pro Cys Pro Val  Leu Gly Thr 
    1055                 1060                 1065             


Ala Glu  Phe Thr Glu Met Cys  Pro Lys Gly Lys Gly  Phe Val Pro 
    1070                 1075                 1080             


Ala Gly  Glu Ser Ser Ser Glu  Ala Gly Gly Glu Asn  Tyr Lys Asp 
    1085                 1090                 1095             


Ala Asp  Glu Cys Leu Leu Phe  Gly Gln Glu Ile Cys  Lys Asn Gly 
    1100                 1105                 1110             


Phe Cys  Leu Asn Thr Arg Pro  Gly Tyr Glu Cys Tyr  Cys Lys Gln 
    1115                 1120                 1125             


Gly Thr  Tyr Tyr Asp Pro Val  Lys Leu Gln Cys Phe  Asp Met Asp 
    1130                 1135                 1140             


Glu Cys  Gln Asp Pro Ser Ser  Cys Ile Asp Gly Gln  Cys Val Asn 
    1145                 1150                 1155             


Thr Glu  Gly Ser Tyr Asn Cys  Phe Cys Thr His Pro  Met Val Leu 
    1160                 1165                 1170             


Asp Ala  Ser Glu Lys Arg Cys  Ile Arg Pro Ala Glu  Ser Asn Glu 
    1175                 1180                 1185             


Gln Ile  Glu Glu Thr Asp Val  Tyr Gln Asp Leu Cys  Trp Glu His 
    1190                 1195                 1200             


Leu Ser  Asp Glu Tyr Val Cys  Ser Arg Pro Leu Val  Gly Lys Gln 
    1205                 1210                 1215             


Thr Thr  Tyr Thr Glu Cys Cys  Cys Leu Tyr Gly Glu  Ala Trp Gly 
    1220                 1225                 1230             


Met Gln  Cys Ala Leu Cys Pro  Leu Lys Asp Ser Asp  Asp Tyr Ala 
    1235                 1240                 1245             


Gln Leu  Cys Asn Ile Pro Val  Thr Gly Arg Arg Gln  Pro Tyr Gly 
    1250                 1255                 1260             


Arg Asp  Ala Leu Val Asp Phe  Ser Glu Gln Tyr Thr  Pro Glu Ala 
    1265                 1270                 1275             


Asp Pro  Tyr Phe Ile Gln Asp  Arg Phe Leu Asn Ser  Phe Glu Glu 
    1280                 1285                 1290             


Leu Gln  Ala Glu Glu Cys Gly  Ile Leu Asn Gly Cys  Glu Asn Gly 
    1295                 1300                 1305             


Arg Cys  Val Arg Val Gln Glu  Gly Tyr Thr Cys Asp  Cys Phe Asp 
    1310                 1315                 1320             


Gly Tyr  His Leu Asp Thr Ala  Lys Met Thr Cys Val  Asp Val Asn 
    1325                 1330                 1335             


Glu Cys  Asp Glu Leu Asn Asn  Arg Met Ser Leu Cys  Lys Asn Ala 
    1340                 1345                 1350             


Lys Cys  Ile Asn Thr Asp Gly  Ser Tyr Lys Cys Leu  Cys Leu Pro 
    1355                 1360                 1365             


Gly Tyr  Val Pro Ser Asp Lys  Pro Asn Tyr Cys Thr  Pro Leu Asn 
    1370                 1375                 1380             


Thr Ala  Leu Asn Leu Glu Lys  Asp Ser Asp Leu Glu  
    1385                 1390                 1395 


<210>  8098
<211>  1353
<212>  PRT
<213>  Homo Sapiens

<400>  8098

Met Asp Thr Lys Leu Met Cys Leu Leu Phe Phe Phe Ser Leu Pro Pro 
1               5                   10                  15      


Leu Leu Val Ser Asn His Thr Gly Arg Ile Lys Val Val Phe Thr Pro 
            20                  25                  30          


Ser Ile Cys Lys Val Thr Cys Thr Lys Gly Ser Cys Gln Asn Ser Cys 
        35                  40                  45              


Glu Lys Gly Asn Thr Thr Thr Leu Ile Ser Glu Asn Gly His Ala Ala 
    50                  55                  60                  


Asp Thr Leu Thr Ala Thr Asn Phe Arg Val Val Ile Cys His Leu Pro 
65                  70                  75                  80  


Cys Met Asn Gly Gly Gln Cys Ser Ser Arg Asp Lys Cys Gln Cys Pro 
                85                  90                  95      


Pro Asn Phe Thr Gly Lys Leu Cys Gln Ile Pro Val His Gly Ala Ser 
            100                 105                 110         


Val Pro Lys Leu Tyr Gln His Ser Gln Gln Pro Gly Lys Ala Leu Gly 
        115                 120                 125             


Thr His Val Ile His Ser Thr His Thr Leu Pro Leu Thr Val Thr Ser 
    130                 135                 140                 


Gln Gln Gly Val Lys Val Lys Phe Pro Pro Asn Ile Val Asn Ile His 
145                 150                 155                 160 


Val Lys His Pro Pro Glu Ala Ser Val Gln Ile His Gln Val Ser Arg 
                165                 170                 175     


Ile Asp Gly Pro Thr Gly Gln Lys Thr Lys Glu Ala Gln Pro Gly Gln 
            180                 185                 190         


Ser Gln Val Ser Tyr Gln Gly Leu Pro Val Gln Lys Thr Gln Thr Ile 
        195                 200                 205             


His Ser Thr Tyr Ser His Gln Gln Val Ile Pro His Val Tyr Pro Val 
    210                 215                 220                 


Ala Ala Lys Thr Gln Leu Gly Arg Cys Phe Gln Glu Thr Ile Gly Ser 
225                 230                 235                 240 


Gln Cys Gly Lys Ala Leu Pro Gly Leu Ser Lys Gln Glu Asp Cys Cys 
                245                 250                 255     


Gly Thr Val Gly Thr Ser Trp Gly Phe Asn Lys Cys Gln Lys Cys Pro 
            260                 265                 270         


Lys Lys Pro Ser Tyr His Gly Tyr Asn Gln Met Met Glu Cys Leu Pro 
        275                 280                 285             


Gly Tyr Lys Arg Val Asn Asn Thr Phe Cys Gln Asp Ile Asn Glu Cys 
    290                 295                 300                 


Gln Leu Gln Gly Val Cys Pro Asn Gly Glu Cys Leu Asn Thr Met Gly 
305                 310                 315                 320 


Ser Tyr Arg Cys Thr Cys Lys Ile Gly Phe Gly Pro Asp Pro Thr Phe 
                325                 330                 335     


Ser Ser Cys Val Pro Asp Pro Pro Val Ile Ser Glu Glu Lys Gly Pro 
            340                 345                 350         


Cys Tyr Arg Leu Val Ser Ser Gly Arg Gln Cys Met His Pro Leu Ser 
        355                 360                 365             


Val His Leu Thr Lys Gln Leu Cys Cys Cys Ser Val Gly Lys Ala Trp 
    370                 375                 380                 


Gly Pro His Cys Glu Lys Cys Pro Leu Pro Gly Thr Ala Ala Phe Lys 
385                 390                 395                 400 


Glu Ile Cys Pro Gly Gly Met Gly Tyr Thr Val Ser Gly Val His Arg 
                405                 410                 415     


Arg Arg Pro Ile His His His Val Gly Lys Gly Pro Val Phe Val Lys 
            420                 425                 430         


Pro Lys Asn Thr Gln Pro Val Ala Lys Ser Thr His Pro Pro Pro Leu 
        435                 440                 445             


Pro Ala Lys Glu Glu Pro Val Glu Ala Leu Thr Phe Ser Arg Glu His 
    450                 455                 460                 


Gly Pro Gly Val Ala Glu Pro Glu Val Ala Thr Ala Pro Pro Glu Lys 
465                 470                 475                 480 


Glu Ile Pro Ser Leu Asp Gln Glu Lys Thr Lys Leu Glu Pro Gly Gln 
                485                 490                 495     


Pro Gln Leu Ser Pro Gly Ile Ser Thr Ile His Leu His Pro Gln Phe 
            500                 505                 510         


Pro Val Val Ile Glu Lys Thr Ser Pro Pro Val Pro Val Glu Val Ala 
        515                 520                 525             


Pro Glu Ala Ser Thr Ser Ser Ala Ser Gln Val Ile Ala Pro Thr Gln 
    530                 535                 540                 


Val Thr Glu Ile Asn Glu Cys Thr Val Asn Pro Asp Ile Cys Gly Ala 
545                 550                 555                 560 


Gly His Cys Ile Asn Leu Pro Val Arg Tyr Thr Cys Ile Cys Tyr Glu 
                565                 570                 575     


Gly Tyr Arg Phe Ser Glu Gln Gln Arg Lys Cys Val Asp Ile Asp Glu 
            580                 585                 590         


Cys Thr Gln Val Gln His Leu Cys Ser Gln Gly Arg Cys Glu Asn Thr 
        595                 600                 605             


Glu Gly Ser Phe Leu Cys Ile Cys Pro Ala Gly Phe Met Ala Ser Glu 
    610                 615                 620                 


Glu Gly Thr Asn Cys Ile Asp Val Asp Glu Cys Leu Arg Pro Asp Val 
625                 630                 635                 640 


Cys Gly Glu Gly His Cys Val Asn Thr Val Gly Ala Phe Arg Cys Glu 
                645                 650                 655     


Tyr Cys Asp Ser Gly Tyr Arg Met Thr Gln Arg Gly Arg Cys Glu Asp 
            660                 665                 670         


Ile Asp Glu Cys Leu Asn Pro Ser Thr Cys Pro Asp Glu Gln Cys Val 
        675                 680                 685             


Asn Ser Pro Gly Ser Tyr Gln Cys Val Pro Cys Thr Glu Gly Phe Arg 
    690                 695                 700                 


Gly Trp Asn Gly Gln Cys Leu Asp Val Asp Glu Cys Leu Glu Pro Asn 
705                 710                 715                 720 


Val Cys Ala Asn Gly Asp Cys Ser Asn Leu Glu Gly Ser Tyr Met Cys 
                725                 730                 735     


Ser Cys His Lys Gly Tyr Thr Arg Thr Pro Asp His Lys His Cys Arg 
            740                 745                 750         


Asp Ile Asp Glu Cys Gln Gln Gly Asn Leu Cys Val Asn Gly Gln Cys 
        755                 760                 765             


Lys Asn Thr Glu Gly Ser Phe Arg Cys Thr Cys Gly Gln Gly Tyr Gln 
    770                 775                 780                 


Leu Ser Ala Ala Lys Asp Gln Cys Glu Asp Ile Asp Glu Cys Gln His 
785                 790                 795                 800 


Arg His Leu Cys Ala His Gly Gln Cys Arg Asn Thr Glu Gly Ser Phe 
                805                 810                 815     


Gln Cys Val Cys Asp Gln Gly Tyr Arg Ala Ser Gly Leu Gly Asp His 
            820                 825                 830         


Cys Glu Asp Ile Asn Glu Cys Leu Glu Asp Lys Ser Val Cys Gln Arg 
        835                 840                 845             


Gly Asp Cys Ile Asn Thr Ala Gly Ser Tyr Asp Cys Thr Cys Pro Asp 
    850                 855                 860                 


Gly Phe Gln Leu Asp Asp Asn Lys Thr Cys Gln Asp Ile Asn Glu Cys 
865                 870                 875                 880 


Glu His Pro Gly Leu Cys Gly Pro Gln Gly Glu Cys Leu Asn Thr Glu 
                885                 890                 895     


Gly Ser Phe His Cys Val Cys Gln Gln Gly Phe Ser Ile Ser Ala Asp 
            900                 905                 910         


Gly Arg Thr Cys Glu Asp Val Asn Glu Cys Glu Leu Leu Ser Gly Val 
        915                 920                 925             


Cys Gly Glu Ala Phe Cys Glu Asn Val Glu Gly Ser Phe Leu Cys Val 
    930                 935                 940                 


Cys Ala Asp Glu Asn Gln Glu Tyr Ser Pro Met Thr Gly Gln Cys Arg 
945                 950                 955                 960 


Ser Arg Thr Ser Thr Asp Leu Asp Val Asp Val Asp Gln Pro Lys Glu 
                965                 970                 975     


Glu Lys Lys Glu Cys Tyr Tyr Asn Leu Asn Asp Ala Ser Leu Cys Asp 
            980                 985                 990         


Asn Val Leu Ala Pro Asn Val Thr  Lys Gln Glu Cys Cys  Cys Thr Ser 
        995                 1000                 1005             


Gly Val  Gly Trp Gly Asp Asn  Cys Glu Ile Phe Pro  Cys Pro Val 
    1010                 1015                 1020             


Leu Gly  Thr Ala Glu Phe Thr  Glu Met Cys Pro Lys  Gly Lys Gly 
    1025                 1030                 1035             


Phe Val  Pro Ala Gly Glu Ser  Ser Ser Glu Ala Gly  Gly Glu Asn 
    1040                 1045                 1050             


Tyr Lys  Asp Ala Asp Glu Cys  Leu Leu Phe Gly Gln  Glu Ile Cys 
    1055                 1060                 1065             


Lys Asn  Gly Phe Cys Leu Asn  Thr Arg Pro Gly Tyr  Glu Cys Tyr 
    1070                 1075                 1080             


Cys Lys  Gln Gly Thr Tyr Tyr  Asp Pro Val Lys Leu  Gln Cys Phe 
    1085                 1090                 1095             


Asp Met  Asp Glu Cys Gln Asp  Pro Ser Ser Cys Ile  Asp Gly Gln 
    1100                 1105                 1110             


Cys Val  Asn Thr Glu Gly Ser  Tyr Asn Cys Phe Cys  Thr His Pro 
    1115                 1120                 1125             


Met Val  Leu Asp Ala Ser Glu  Lys Arg Cys Ile Arg  Pro Ala Glu 
    1130                 1135                 1140             


Ser Asn  Glu Gln Ile Glu Glu  Thr Asp Val Tyr Gln  Asp Leu Cys 
    1145                 1150                 1155             


Trp Glu  His Leu Ser Asp Glu  Tyr Val Cys Ser Arg  Pro Leu Val 
    1160                 1165                 1170             


Gly Lys  Gln Thr Thr Tyr Thr  Glu Cys Cys Cys Leu  Tyr Gly Glu 
    1175                 1180                 1185             


Ala Trp  Gly Met Gln Cys Ala  Leu Cys Pro Leu Lys  Asp Ser Asp 
    1190                 1195                 1200             


Asp Tyr  Ala Gln Leu Cys Asn  Ile Pro Val Thr Gly  Arg Arg Gln 
    1205                 1210                 1215             


Pro Tyr  Gly Arg Asp Ala Leu  Val Asp Phe Ser Glu  Gln Tyr Thr 
    1220                 1225                 1230             


Pro Glu  Ala Asp Pro Tyr Phe  Ile Gln Asp Arg Phe  Leu Asn Ser 
    1235                 1240                 1245             


Phe Glu  Glu Leu Gln Ala Glu  Glu Cys Gly Ile Leu  Asn Gly Cys 
    1250                 1255                 1260             


Glu Asn  Gly Arg Cys Val Arg  Val Gln Glu Gly Tyr  Thr Cys Asp 
    1265                 1270                 1275             


Cys Phe  Asp Gly Tyr His Leu  Asp Thr Ala Lys Met  Thr Cys Val 
    1280                 1285                 1290             


Asp Val  Asn Glu Cys Asp Glu  Leu Asn Asn Arg Met  Ser Leu Cys 
    1295                 1300                 1305             


Lys Asn  Ala Lys Cys Ile Asn  Thr Asp Gly Ser Tyr  Lys Cys Leu 
    1310                 1315                 1320             


Cys Leu  Pro Gly Tyr Val Pro  Ser Asp Lys Pro Asn  Tyr Cys Thr 
    1325                 1330                 1335             


Pro Leu  Asn Thr Ala Leu Asn  Leu Glu Lys Asp Ser  Asp Leu Glu 
    1340                 1345                 1350             


<210>  8099
<211>  1342
<212>  PRT
<213>  Homo Sapiens

<400>  8099

Met Asp Thr Lys Leu Met Cys Leu Leu Phe Phe Phe Ser Leu Pro Pro 
1               5                   10                  15      


Leu Leu Val Ser Asn His Thr Gly Arg Ile Lys Val Val Phe Thr Pro 
            20                  25                  30          


Ser Ile Cys Lys Val Thr Cys Thr Lys Gly Ser Cys Gln Asn Ser Cys 
        35                  40                  45              


Glu Lys Gly Asn Thr Thr Thr Leu Ile Ser Glu Asn Gly His Ala Ala 
    50                  55                  60                  


Asp Thr Leu Thr Ala Thr Asn Phe Arg Val Val Ile Cys His Leu Pro 
65                  70                  75                  80  


Cys Met Asn Gly Gly Gln Cys Ser Ser Arg Asp Lys Cys Gln Cys Pro 
                85                  90                  95      


Pro Asn Phe Thr Gly Lys Leu Cys Gln Ile Pro Val His Gly Ala Ser 
            100                 105                 110         


Val Pro Lys Leu Tyr Gln His Ser Gln Gln Pro Gly Lys Ala Leu Gly 
        115                 120                 125             


Thr His Val Ile His Ser Thr His Thr Leu Pro Leu Thr Val Thr Ser 
    130                 135                 140                 


Gln Gln Gly Val Lys Val Lys Phe Pro Pro Asn Ile Val Asn Ile His 
145                 150                 155                 160 


Val Lys His Pro Pro Glu Ala Ser Val Gln Ile His Gln Val Ser Arg 
                165                 170                 175     


Ile Asp Gly Pro Thr Gly Gln Lys Thr Lys Glu Ala Gln Pro Gly Gln 
            180                 185                 190         


Ser Gln Val Ser Tyr Gln Gly Leu Pro Val Gln Lys Thr Gln Thr Ile 
        195                 200                 205             


His Ser Thr Tyr Ser His Gln Gln Val Ile Pro His Val Tyr Pro Val 
    210                 215                 220                 


Ala Ala Lys Thr Gln Leu Gly Arg Cys Phe Gln Glu Thr Ile Gly Ser 
225                 230                 235                 240 


Gln Cys Gly Lys Ala Leu Pro Gly Leu Ser Lys Gln Glu Asp Cys Cys 
                245                 250                 255     


Gly Thr Val Gly Thr Ser Trp Gly Phe Asn Lys Cys Gln Lys Cys Pro 
            260                 265                 270         


Lys Lys Pro Ser Tyr His Gly Tyr Asn Gln Met Met Glu Cys Leu Pro 
        275                 280                 285             


Gly Tyr Lys Arg Val Asn Asn Thr Phe Cys Gln Asp Ile Asn Glu Cys 
    290                 295                 300                 


Gln Leu Gln Gly Val Cys Pro Asn Gly Glu Cys Leu Asn Thr Met Gly 
305                 310                 315                 320 


Ser Tyr Arg Cys Thr Cys Lys Ile Gly Phe Gly Pro Asp Pro Thr Phe 
                325                 330                 335     


Ser Ser Cys Val Pro Asp Pro Pro Val Ile Ser Glu Glu Lys Gly Pro 
            340                 345                 350         


Cys Tyr Arg Leu Val Ser Ser Gly Arg Gln Cys Met His Pro Leu Ser 
        355                 360                 365             


Val His Leu Thr Lys Gln Leu Cys Cys Cys Ser Val Gly Lys Ala Trp 
    370                 375                 380                 


Gly Pro His Cys Glu Lys Cys Pro Leu Pro Gly Thr Ala Lys Glu Glu 
385                 390                 395                 400 


Pro Val Glu Ala Leu Thr Phe Ser Arg Glu His Gly Pro Gly Val Ala 
                405                 410                 415     


Glu Pro Glu Val Ala Thr Ala Pro Pro Glu Lys Glu Ile Pro Ser Leu 
            420                 425                 430         


Asp Gln Glu Lys Thr Lys Leu Glu Pro Gly Gln Pro Gln Leu Ser Pro 
        435                 440                 445             


Gly Ile Ser Thr Ile His Leu His Pro Gln Phe Pro Val Val Ile Glu 
    450                 455                 460                 


Lys Thr Ser Pro Pro Val Pro Val Glu Val Ala Pro Glu Ala Ser Thr 
465                 470                 475                 480 


Ser Ser Ala Ser Gln Val Ile Ala Pro Thr Gln Val Thr Glu Ile Asn 
                485                 490                 495     


Glu Cys Thr Val Asn Pro Asp Ile Cys Gly Ala Gly His Cys Ile Asn 
            500                 505                 510         


Leu Pro Val Arg Tyr Thr Cys Ile Cys Tyr Glu Gly Tyr Arg Phe Ser 
        515                 520                 525             


Glu Gln Gln Arg Lys Cys Val Asp Ile Asp Glu Cys Thr Gln Val Gln 
    530                 535                 540                 


His Leu Cys Ser Gln Gly Arg Cys Glu Asn Thr Glu Gly Ser Phe Leu 
545                 550                 555                 560 


Cys Ile Cys Pro Ala Gly Phe Met Ala Ser Glu Glu Gly Thr Asn Cys 
                565                 570                 575     


Ile Asp Val Asp Glu Cys Leu Arg Pro Asp Val Cys Gly Glu Gly His 
            580                 585                 590         


Cys Val Asn Thr Val Gly Ala Phe Arg Cys Glu Tyr Cys Asp Ser Gly 
        595                 600                 605             


Tyr Arg Met Thr Gln Arg Gly Arg Cys Glu Asp Ile Asp Glu Cys Leu 
    610                 615                 620                 


Asn Pro Ser Thr Cys Pro Asp Glu Gln Cys Val Asn Ser Pro Gly Ser 
625                 630                 635                 640 


Tyr Gln Cys Val Pro Cys Thr Glu Gly Phe Arg Gly Trp Asn Gly Gln 
                645                 650                 655     


Cys Leu Asp Val Asp Glu Cys Leu Glu Pro Asn Val Cys Ala Asn Gly 
            660                 665                 670         


Asp Cys Ser Asn Leu Glu Gly Ser Tyr Met Cys Ser Cys His Lys Gly 
        675                 680                 685             


Tyr Thr Arg Thr Pro Asp His Lys His Cys Arg Asp Ile Asp Glu Cys 
    690                 695                 700                 


Gln Gln Gly Asn Leu Cys Val Asn Gly Gln Cys Lys Asn Thr Glu Gly 
705                 710                 715                 720 


Ser Phe Arg Cys Thr Cys Gly Gln Gly Tyr Gln Leu Ser Ala Ala Lys 
                725                 730                 735     


Asp Gln Cys Glu Asp Ile Asp Glu Cys Gln His Arg His Leu Cys Ala 
            740                 745                 750         


His Gly Gln Cys Arg Asn Thr Glu Gly Ser Phe Gln Cys Val Cys Asp 
        755                 760                 765             


Gln Gly Tyr Arg Ala Ser Gly Leu Gly Asp His Cys Glu Asp Ile Asn 
    770                 775                 780                 


Glu Cys Leu Glu Asp Lys Ser Val Cys Gln Arg Gly Asp Cys Ile Asn 
785                 790                 795                 800 


Thr Ala Gly Ser Tyr Asp Cys Thr Cys Pro Asp Gly Phe Gln Leu Asp 
                805                 810                 815     


Asp Asn Lys Thr Cys Gln Asp Ile Asn Glu Cys Glu His Pro Gly Leu 
            820                 825                 830         


Cys Gly Pro Gln Gly Glu Cys Leu Asn Thr Glu Gly Ser Phe His Cys 
        835                 840                 845             


Val Cys Gln Gln Gly Phe Ser Ile Ser Ala Asp Gly Arg Thr Cys Glu 
    850                 855                 860                 


Asp Ile Asp Glu Cys Val Asn Asn Thr Val Cys Asp Ser His Gly Phe 
865                 870                 875                 880 


Cys Asp Asn Thr Ala Gly Ser Phe Arg Cys Leu Cys Tyr Gln Gly Phe 
                885                 890                 895     


Gln Ala Pro Gln Asp Gly Gln Gly Cys Val Asp Val Asn Glu Cys Glu 
            900                 905                 910         


Leu Leu Ser Gly Val Cys Gly Glu Ala Phe Cys Glu Asn Val Glu Gly 
        915                 920                 925             


Ser Phe Leu Cys Val Cys Ala Asp Glu Asn Gln Glu Tyr Ser Pro Met 
    930                 935                 940                 


Thr Gly Gln Cys Arg Ser Arg Thr Ser Thr Asp Leu Asp Val Asp Val 
945                 950                 955                 960 


Asp Gln Pro Lys Glu Glu Lys Lys Glu Cys Tyr Tyr Asn Leu Asn Asp 
                965                 970                 975     


Ala Ser Leu Cys Asp Asn Val Leu Ala Pro Asn Val Thr Lys Gln Glu 
            980                 985                 990         


Cys Cys Cys Thr Ser Gly Val Gly  Trp Gly Asp Asn Cys  Glu Ile Phe 
        995                 1000                 1005             


Pro Cys  Pro Val Leu Gly Thr  Ala Glu Phe Thr Glu  Met Cys Pro 
    1010                 1015                 1020             


Lys Gly  Lys Gly Phe Val Pro  Ala Gly Glu Ser Ser  Ser Glu Ala 
    1025                 1030                 1035             


Gly Gly  Glu Asn Tyr Lys Asp  Ala Asp Glu Cys Leu  Leu Phe Gly 
    1040                 1045                 1050             


Gln Glu  Ile Cys Lys Asn Gly  Phe Cys Leu Asn Thr  Arg Pro Gly 
    1055                 1060                 1065             


Tyr Glu  Cys Tyr Cys Lys Gln  Gly Thr Tyr Tyr Asp  Pro Val Lys 
    1070                 1075                 1080             


Leu Gln  Cys Phe Asp Met Asp  Glu Cys Gln Asp Pro  Ser Ser Cys 
    1085                 1090                 1095             


Ile Asp  Gly Gln Cys Val Asn  Thr Glu Gly Ser Tyr  Asn Cys Phe 
    1100                 1105                 1110             


Cys Thr  His Pro Met Val Leu  Asp Ala Ser Glu Lys  Arg Cys Ile 
    1115                 1120                 1125             


Arg Pro  Ala Glu Ser Asn Glu  Gln Ile Glu Glu Thr  Asp Val Tyr 
    1130                 1135                 1140             


Gln Asp  Leu Cys Trp Glu His  Leu Ser Asp Glu Tyr  Val Cys Ser 
    1145                 1150                 1155             


Arg Pro  Leu Val Gly Lys Gln  Thr Thr Tyr Thr Glu  Cys Cys Cys 
    1160                 1165                 1170             


Leu Tyr  Gly Glu Ala Trp Gly  Met Gln Cys Ala Leu  Cys Pro Leu 
    1175                 1180                 1185             


Lys Asp  Ser Asp Asp Tyr Ala  Gln Leu Cys Asn Ile  Pro Val Thr 
    1190                 1195                 1200             


Gly Arg  Arg Gln Pro Tyr Gly  Arg Asp Ala Leu Val  Asp Phe Ser 
    1205                 1210                 1215             


Glu Gln  Tyr Thr Pro Glu Ala  Asp Pro Tyr Phe Ile  Gln Asp Arg 
    1220                 1225                 1230             


Phe Leu  Asn Ser Phe Glu Glu  Leu Gln Ala Glu Glu  Cys Gly Ile 
    1235                 1240                 1245             


Leu Asn  Gly Cys Glu Asn Gly  Arg Cys Val Arg Val  Gln Glu Gly 
    1250                 1255                 1260             


Tyr Thr  Cys Asp Cys Phe Asp  Gly Tyr His Leu Asp  Thr Ala Lys 
    1265                 1270                 1275             


Met Thr  Cys Val Asp Val Asn  Glu Cys Asp Glu Leu  Asn Asn Arg 
    1280                 1285                 1290             


Met Ser  Leu Cys Lys Asn Ala  Lys Cys Ile Asn Thr  Asp Gly Ser 
    1295                 1300                 1305             


Tyr Lys  Cys Leu Cys Leu Pro  Gly Tyr Val Pro Ser  Asp Lys Pro 
    1310                 1315                 1320             


Asn Tyr  Cys Thr Pro Leu Asn  Thr Ala Leu Asn Leu  Glu Lys Asp 
    1325                 1330                 1335             


Ser Asp  Leu Glu 
    1340         


<210>  8100
<211>  1340
<212>  PRT
<213>  Homo Sapiens

<400>  8100

Met Asp Thr Lys Leu Met Cys Leu Leu Phe Phe Phe Ser Leu Pro Pro 
1               5                   10                  15      


Leu Leu Val Ser Asn His Thr Gly Arg Ile Lys Val Val Phe Thr Pro 
            20                  25                  30          


Ser Ile Cys Lys Val Thr Cys Thr Lys Gly Ser Cys Gln Asn Ser Cys 
        35                  40                  45              


Glu Lys Gly Asn Thr Thr Thr Leu Ile Ser Glu Asn Gly His Ala Ala 
    50                  55                  60                  


Asp Thr Leu Thr Ala Thr Asn Phe Arg Val Val Ile Cys His Leu Pro 
65                  70                  75                  80  


Cys Met Asn Gly Gly Gln Cys Ser Ser Arg Asp Lys Cys Gln Cys Pro 
                85                  90                  95      


Pro Asn Phe Thr Gly Lys Leu Cys Gln Ile Pro Val His Gly Ala Ser 
            100                 105                 110         


Val Pro Lys Leu Tyr Gln His Ser Gln Gln Pro Gly Lys Ala Leu Gly 
        115                 120                 125             


Thr His Val Ile His Ser Thr His Thr Leu Pro Leu Thr Val Thr Ser 
    130                 135                 140                 


Gln Gln Gly Val Lys Val Lys Phe Pro Pro Asn Ile Val Asn Ile His 
145                 150                 155                 160 


Val Lys His Pro Pro Glu Ala Ser Val Gln Ile His Gln Val Ser Arg 
                165                 170                 175     


Ile Asp Gly Pro Thr Gly Gln Lys Thr Lys Glu Ala Gln Pro Gly Gln 
            180                 185                 190         


Ser Gln Val Ser Tyr Gln Gly Leu Pro Val Gln Lys Thr Gln Thr Ile 
        195                 200                 205             


His Ser Thr Tyr Ser His Gln Gln Val Ile Pro His Val Tyr Pro Val 
    210                 215                 220                 


Ala Ala Lys Thr Gln Leu Gly Arg Cys Phe Gln Glu Thr Ile Gly Ser 
225                 230                 235                 240 


Gln Cys Gly Lys Ala Leu Pro Gly Leu Ser Lys Gln Glu Asp Cys Cys 
                245                 250                 255     


Gly Thr Val Gly Thr Ser Trp Gly Phe Asn Lys Cys Gln Lys Cys Pro 
            260                 265                 270         


Lys Lys Pro Ser Tyr His Gly Tyr Asn Gln Met Met Glu Cys Leu Pro 
        275                 280                 285             


Gly Tyr Lys Arg Val Asn Asn Thr Phe Cys Gln Asp Ile Asn Glu Cys 
    290                 295                 300                 


Gln Leu Gln Gly Val Cys Pro Asn Gly Glu Cys Leu Asn Thr Met Gly 
305                 310                 315                 320 


Ser Tyr Arg Cys Thr Cys Lys Ile Gly Phe Gly Pro Asp Pro Thr Phe 
                325                 330                 335     


Ser Ser Cys Val Pro Asp Pro Pro Val Ile Ser Glu Glu Lys Gly Pro 
            340                 345                 350         


Cys Tyr Arg Leu Val Ser Ser Gly Arg Gln Cys Met His Pro Leu Ser 
        355                 360                 365             


Val His Leu Thr Lys Gln Leu Cys Cys Cys Ser Val Gly Lys Ala Trp 
    370                 375                 380                 


Gly Pro His Cys Glu Lys Cys Pro Leu Pro Gly Thr Ala Lys Glu Glu 
385                 390                 395                 400 


Pro Val Glu Ala Leu Thr Phe Ser Arg Glu His Gly Pro Gly Val Ala 
                405                 410                 415     


Glu Pro Glu Val Ala Thr Ala Pro Pro Glu Lys Glu Ile Pro Ser Leu 
            420                 425                 430         


Asp Gln Glu Lys Thr Lys Leu Glu Pro Gly Gln Pro Gln Leu Ser Pro 
        435                 440                 445             


Gly Ile Ser Thr Ile His Leu His Pro Gln Phe Pro Val Val Ile Glu 
    450                 455                 460                 


Lys Thr Ser Pro Pro Val Pro Val Glu Val Ala Pro Glu Ala Ser Thr 
465                 470                 475                 480 


Ser Ser Ala Ser Gln Val Ile Ala Pro Thr Gln Val Thr Glu Ile Asn 
                485                 490                 495     


Glu Cys Thr Val Asn Pro Asp Ile Cys Gly Ala Gly His Cys Ile Asn 
            500                 505                 510         


Leu Pro Val Arg Tyr Thr Cys Ile Cys Tyr Glu Gly Tyr Arg Phe Ser 
        515                 520                 525             


Glu Gln Gln Arg Lys Cys Val Asp Ile Asp Glu Cys Thr Gln Val Gln 
    530                 535                 540                 


His Leu Cys Ser Gln Gly Arg Cys Glu Asn Thr Glu Gly Ser Phe Leu 
545                 550                 555                 560 


Cys Ile Cys Pro Ala Gly Phe Met Ala Ser Glu Glu Gly Thr Asn Cys 
                565                 570                 575     


Ile Asp Val Asp Glu Cys Leu Arg Pro Asp Val Cys Gly Glu Gly His 
            580                 585                 590         


Cys Val Asn Thr Val Gly Ala Phe Arg Cys Glu Tyr Cys Asp Ser Gly 
        595                 600                 605             


Tyr Arg Met Thr Gln Arg Gly Arg Cys Glu Asp Ile Asp Glu Cys Leu 
    610                 615                 620                 


Asn Pro Ser Thr Cys Pro Asp Glu Gln Cys Val Asn Ser Pro Gly Ser 
625                 630                 635                 640 


Tyr Gln Cys Val Pro Cys Thr Glu Gly Phe Arg Gly Trp Asn Gly Gln 
                645                 650                 655     


Cys Leu Asp Val Asp Glu Cys Leu Glu Pro Asn Val Cys Ala Asn Gly 
            660                 665                 670         


Asp Cys Ser Asn Leu Glu Gly Ser Tyr Met Cys Ser Cys His Lys Gly 
        675                 680                 685             


Tyr Thr Arg Thr Pro Asp His Lys His Cys Arg Asp Ile Asp Glu Cys 
    690                 695                 700                 


Gln Gln Gly Asn Leu Cys Val Asn Gly Gln Cys Lys Asn Thr Glu Gly 
705                 710                 715                 720 


Ser Phe Arg Cys Thr Cys Gly Gln Gly Tyr Gln Leu Ser Ala Ala Lys 
                725                 730                 735     


Asp Gln Cys Glu Asp Ile Asp Glu Cys Gln His Arg His Leu Cys Ala 
            740                 745                 750         


His Gly Gln Cys Arg Asn Thr Glu Gly Ser Phe Gln Cys Val Cys Asp 
        755                 760                 765             


Gln Gly Tyr Arg Ala Ser Gly Leu Gly Asp His Cys Glu Asp Ile Asn 
    770                 775                 780                 


Glu Cys Leu Glu Asp Lys Ser Val Cys Gln Arg Gly Asp Cys Ile Asn 
785                 790                 795                 800 


Thr Ala Gly Ser Tyr Asp Cys Thr Cys Pro Asp Gly Phe Gln Leu Asp 
                805                 810                 815     


Asp Asn Lys Thr Cys Gln Asp Ile Asn Glu Cys Glu His Pro Gly Leu 
            820                 825                 830         


Cys Gly Pro Gln Gly Glu Cys Leu Asn Thr Glu Gly Ser Phe His Cys 
        835                 840                 845             


Val Cys Gln Gln Gly Phe Ser Ile Ser Ala Asp Gly Arg Thr Cys Glu 
    850                 855                 860                 


Asp Ile Asp Glu Cys Val Asn Asn Thr Val Cys Asp Ser His Gly Phe 
865                 870                 875                 880 


Cys Asp Asn Thr Ala Gly Ser Phe Arg Cys Leu Cys Tyr Gln Gly Phe 
                885                 890                 895     


Gln Ala Pro Gln Asp Gly Gln Gly Cys Val Asp Val Asn Glu Cys Glu 
            900                 905                 910         


Leu Leu Ser Gly Val Cys Gly Glu Ala Phe Cys Glu Asn Val Glu Gly 
        915                 920                 925             


Ser Phe Leu Cys Val Cys Ala Asp Glu Asn Gln Glu Tyr Ser Pro Met 
    930                 935                 940                 


Thr Gly Gln Cys Arg Ser Arg Thr Ser Thr Asp Val Asp Val Asp Gln 
945                 950                 955                 960 


Pro Lys Glu Glu Lys Lys Glu Cys Tyr Tyr Asn Leu Asn Asp Ala Ser 
                965                 970                 975     


Leu Cys Asp Asn Val Leu Ala Pro Asn Val Thr Lys Gln Glu Cys Cys 
            980                 985                 990         


Cys Thr Ser Gly Val Gly Trp Gly  Asp Asn Cys Glu Ile  Phe Pro Cys 
        995                 1000                 1005             


Pro Val  Leu Gly Thr Ala Glu  Phe Thr Glu Met Cys  Pro Lys Gly 
    1010                 1015                 1020             


Lys Gly  Phe Val Pro Ala Gly  Glu Ser Ser Ser Glu  Ala Gly Gly 
    1025                 1030                 1035             


Glu Asn  Tyr Lys Asp Ala Asp  Glu Cys Leu Leu Phe  Gly Gln Glu 
    1040                 1045                 1050             


Ile Cys  Lys Asn Gly Phe Cys  Leu Asn Thr Arg Pro  Gly Tyr Glu 
    1055                 1060                 1065             


Cys Tyr  Cys Lys Gln Gly Thr  Tyr Tyr Asp Pro Val  Lys Leu Gln 
    1070                 1075                 1080             


Cys Phe  Asp Met Asp Glu Cys  Gln Asp Pro Ser Ser  Cys Ile Asp 
    1085                 1090                 1095             


Gly Gln  Cys Val Asn Thr Glu  Gly Ser Tyr Asn Cys  Phe Cys Thr 
    1100                 1105                 1110             


His Pro  Met Val Leu Asp Ala  Ser Glu Lys Arg Cys  Ile Arg Pro 
    1115                 1120                 1125             


Ala Glu  Ser Asn Glu Gln Ile  Glu Glu Thr Asp Val  Tyr Gln Asp 
    1130                 1135                 1140             


Leu Cys  Trp Glu His Leu Ser  Asp Glu Tyr Val Cys  Ser Arg Pro 
    1145                 1150                 1155             


Leu Val  Gly Lys Gln Thr Thr  Tyr Thr Glu Cys Cys  Cys Leu Tyr 
    1160                 1165                 1170             


Gly Glu  Ala Trp Gly Met Gln  Cys Ala Leu Cys Pro  Leu Lys Asp 
    1175                 1180                 1185             


Ser Asp  Asp Tyr Ala Gln Leu  Cys Asn Ile Pro Val  Thr Gly Arg 
    1190                 1195                 1200             


Arg Gln  Pro Tyr Gly Arg Asp  Ala Leu Val Asp Phe  Ser Glu Gln 
    1205                 1210                 1215             


Tyr Thr  Pro Glu Ala Asp Pro  Tyr Phe Ile Gln Asp  Arg Phe Leu 
    1220                 1225                 1230             


Asn Ser  Phe Glu Glu Leu Gln  Ala Glu Glu Cys Gly  Ile Leu Asn 
    1235                 1240                 1245             


Gly Cys  Glu Asn Gly Arg Cys  Val Arg Val Gln Glu  Gly Tyr Thr 
    1250                 1255                 1260             


Cys Asp  Cys Phe Asp Gly Tyr  His Leu Asp Thr Ala  Lys Met Thr 
    1265                 1270                 1275             


Cys Val  Asp Val Asn Glu Cys  Asp Glu Leu Asn Asn  Arg Met Ser 
    1280                 1285                 1290             


Leu Cys  Lys Asn Ala Lys Cys  Ile Asn Thr Asp Gly  Ser Tyr Lys 
    1295                 1300                 1305             


Cys Leu  Cys Leu Pro Gly Tyr  Val Pro Ser Asp Lys  Pro Asn Tyr 
    1310                 1315                 1320             


Cys Thr  Pro Leu Asn Thr Ala  Leu Asn Leu Glu Lys  Asp Ser Asp 
    1325                 1330                 1335             


Leu Glu  
    1340 


<210>  8101
<211>  219
<212>  PRT
<213>  Homo Sapiens

<400>  8101

Met Gly Ser Tyr Arg Cys Thr Cys Lys Ile Gly Phe Gly Pro Asp Pro 
1               5                   10                  15      


Thr Phe Ser Ser Cys Val Pro Asp Pro Pro Val Ile Ser Glu Glu Lys 
            20                  25                  30          


Gly Pro Cys Tyr Arg Leu Val Ser Ser Gly Arg Gln Cys Met His Pro 
        35                  40                  45              


Leu Ser Val His Leu Thr Lys Gln Leu Cys Cys Cys Ser Val Gly Lys 
    50                  55                  60                  


Ala Trp Gly Pro His Cys Glu Lys Cys Pro Leu Pro Gly Thr Gly Lys 
65                  70                  75                  80  


Gly Pro Val Phe Val Lys Pro Lys Asn Thr Gln Pro Val Ala Lys Ser 
                85                  90                  95      


Thr His Pro Pro Pro Leu Pro Ala Lys Glu Glu Pro Val Glu Ala Leu 
            100                 105                 110         


Thr Phe Ser Arg Glu His Gly Pro Gly Val Ala Glu Pro Glu Val Ala 
        115                 120                 125             


Thr Ala Pro Pro Glu Lys Glu Ile Pro Ser Leu Asp Gln Glu Lys Thr 
    130                 135                 140                 


Lys Leu Glu Pro Gly Gln Pro Gln Leu Ser Pro Gly Ile Ser Thr Ile 
145                 150                 155                 160 


His Leu His Pro Gln Phe Pro Val Val Ile Glu Lys Thr Ser Pro Pro 
                165                 170                 175     


Val Pro Val Glu Val Ala Pro Glu Ala Ser Thr Ser Ser Ala Ser Gln 
            180                 185                 190         


Val Ile Ala Pro Thr Gln Val Thr Glu Ile Asn Glu Cys Thr Val Asn 
        195                 200                 205             


Pro Asp Ile Cys Gly Ala Gly His Cys Ile Asn 
    210                 215                 


<210>  8102
<211>  101
<212>  PRT
<213>  Homo Sapiens

<400>  8102

Met Asn Gly Gly Gln Cys Ser Ser Arg Asp Lys Cys Gln Cys Pro Pro 
1               5                   10                  15      


Asn Phe Thr Gly Lys Leu Cys Gln Ile Pro Val His Gly Ala Ser Val 
            20                  25                  30          


Pro Lys Leu Tyr Gln His Ser Gln Gln Pro Gly Lys Ala Leu Gly Thr 
        35                  40                  45              


His Val Ile His Ser Thr His Thr Leu Pro Leu Thr Val Thr Ser Gln 
    50                  55                  60                  


Gln Gly Val Lys Val Lys Phe Pro Pro Asn Ile Val Asn Ile His Val 
65                  70                  75                  80  


Lys His Pro Pro Glu Ala Ser Val Gln Ile His Gln Val Ser Arg Ile 
                85                  90                  95      


Asp Gly Pro Thr Gly 
            100     


<210>  8103
<211>  221
<212>  PRT
<213>  Homo Sapiens

<400>  8103

Ser Ser Gly Arg Gln Cys Met His Pro Leu Ser Val His Leu Thr Lys 
1               5                   10                  15      


Gln Leu Cys Cys Cys Ser Val Gly Lys Ala Trp Gly Pro His Cys Glu 
            20                  25                  30          


Lys Cys Pro Leu Pro Gly Thr Ala Ala Phe Lys Glu Ile Cys Pro Gly 
        35                  40                  45              


Gly Met Gly Tyr Thr Val Ser Gly Val His Arg Arg Arg Pro Ile His 
    50                  55                  60                  


His His Val Gly Lys Gly Pro Val Phe Val Lys Pro Lys Asn Thr Gln 
65                  70                  75                  80  


Pro Val Ala Lys Ser Thr His Pro Pro Pro Leu Pro Ala Lys Glu Glu 
                85                  90                  95      


Pro Val Glu Ala Leu Thr Phe Ser Arg Glu His Gly Pro Gly Val Ala 
            100                 105                 110         


Glu Pro Glu Val Ala Thr Ala Pro Pro Glu Lys Glu Ile Pro Ser Leu 
        115                 120                 125             


Asp Gln Glu Lys Thr Lys Leu Glu Pro Gly Gln Pro Gln Leu Ser Pro 
    130                 135                 140                 


Gly Ile Ser Thr Ile His Leu His Pro Gln Phe Pro Gly Ile Val Ile 
145                 150                 155                 160 


Glu Lys Thr Ser Pro Pro Val Pro Val Glu Val Ala Pro Glu Ala Ser 
                165                 170                 175     


Thr Ser Ser Ala Ser Gln Val Ile Ala Pro Thr Gln Val Thr Glu Ile 
            180                 185                 190         


Asn Glu Cys Thr Val Asn Pro Asp Ile Cys Gly Ala Gly His Cys Ile 
        195                 200                 205             


Asn Leu Pro Val Arg Tyr Thr Cys Ile Cys Tyr Glu Gly 
    210                 215                 220     


<210>  8104
<211>  267
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8104

Xaa Gly Arg Cys Glu Asp Ile Asp Glu Cys Leu Asn Pro Ser Thr Cys 
1               5                   10                  15      


Pro Asp Glu Gln Cys Val Asn Ser Pro Gly Ser Tyr Gln Cys Val Pro 
            20                  25                  30          


Cys Thr Glu Gly Phe Arg Gly Trp Asn Gly Gln Cys Leu Asp Ile Asp 
        35                  40                  45              


Glu Cys Gln Gln Gly Asn Leu Cys Val Asn Gly Gln Cys Lys Asn Thr 
    50                  55                  60                  


Glu Gly Ser Phe Arg Cys Thr Cys Gly Gln Gly Tyr Gln Leu Ser Ala 
65                  70                  75                  80  


Ala Lys Asp Gln Cys Glu Asp Ile Asp Glu Cys Gln His Arg His Leu 
                85                  90                  95      


Cys Ala His Gly Gln Cys Arg Asn Thr Glu Gly Ser Phe Gln Cys Val 
            100                 105                 110         


Cys Asp Gln Gly Tyr Arg Ala Ser Gly Leu Gly Asp His Cys Glu Asp 
        115                 120                 125             


Ile Asn Glu Cys Leu Glu Asp Lys Ser Val Cys Gln Arg Gly Asp Cys 
    130                 135                 140                 


Ile Asn Thr Ala Gly Ser Tyr Asp Cys Thr Cys Pro Asp Gly Phe Gln 
145                 150                 155                 160 


Leu Asp Asp Asn Lys Thr Cys Gln Asp Ile Asn Glu Cys Glu His Pro 
                165                 170                 175     


Gly Leu Cys Gly Pro Gln Gly Glu Cys Leu Asn Thr Glu Gly Ser Phe 
            180                 185                 190         


His Cys Val Cys Gln Gln Gly Phe Ser Ile Ser Ala Asp Gly Arg Thr 
        195                 200                 205             


Cys Glu Asp Ile Asp Glu Cys Val Asn Asn Thr Val Cys Asp Ser His 
    210                 215                 220                 


Gly Phe Cys Asp Asn Thr Ala Gly Ser Phe Arg Cys Leu Cys Tyr Gln 
225                 230                 235                 240 


Gly Phe Gln Ala Pro Gln Asp Gly Gln Gly Cys Val Asp Val Asn Glu 
                245                 250                 255     


Cys Glu Leu Leu Ser Gly Val Cys Gly Glu Ala 
            260                 265         


<210>  8105
<211>  1821
<212>  PRT
<213>  Homo Sapiens

<400>  8105

Met Arg Pro Arg Thr Lys Ala Arg Ser Pro Gly Arg Ala Leu Arg Asn 
1               5                   10                  15      


Pro Trp Arg Gly Phe Leu Pro Leu Thr Leu Ala Leu Phe Val Gly Ala 
            20                  25                  30          


Gly His Ala Gln Arg Asp Pro Val Gly Arg Tyr Glu Pro Ala Gly Gly 
        35                  40                  45              


Asp Ala Asn Arg Leu Arg Arg Pro Gly Gly Ser Tyr Pro Ala Ala Ala 
    50                  55                  60                  


Ala Ala Lys Val Tyr Ser Leu Phe Arg Glu Gln Asp Ala Pro Val Ala 
65                  70                  75                  80  


Gly Leu Gln Pro Val Glu Arg Ala Gln Pro Gly Trp Gly Ser Pro Arg 
                85                  90                  95      


Arg Pro Thr Glu Ala Glu Ala Arg Arg Pro Ser Arg Ala Gln Gln Ser 
            100                 105                 110         


Arg Arg Val Gln Pro Pro Ala Gln Thr Arg Arg Ser Thr Pro Leu Gly 
        115                 120                 125             


Gln Gln Gln Pro Ala Pro Arg Thr Arg Ala Ala Pro Ala Leu Pro Arg 
    130                 135                 140                 


Leu Gly Thr Pro Gln Arg Ser Gly Ala Ala Pro Pro Thr Pro Pro Arg 
145                 150                 155                 160 


Gly Arg Leu Thr Gly Arg Asn Val Cys Gly Gly Gln Cys Cys Pro Gly 
                165                 170                 175     


Trp Thr Thr Ala Asn Ser Thr Asn His Cys Ile Lys Pro Val Cys Glu 
            180                 185                 190         


Pro Pro Cys Gln Asn Arg Gly Ser Cys Ser Arg Pro Gln Leu Cys Val 
        195                 200                 205             


Cys Arg Ser Gly Phe Arg Gly Ala Arg Cys Glu Glu Val Ile Pro Asp 
    210                 215                 220                 


Glu Glu Phe Asp Pro Gln Asn Ser Arg Leu Ala Pro Arg Arg Trp Ala 
225                 230                 235                 240 


Glu Arg Ser Pro Asn Leu Arg Arg Ser Ser Ala Ala Gly Glu Gly Thr 
                245                 250                 255     


Leu Ala Arg Ala Gln Pro Pro Ala Pro Gln Ser Pro Pro Ala Pro Gln 
            260                 265                 270         


Ser Pro Pro Ala Gly Thr Leu Ser Gly Leu Ser Gln Thr His Pro Ser 
        275                 280                 285             


Gln Gln His Val Gly Leu Ser Arg Thr Val Arg Leu His Pro Thr Ala 
    290                 295                 300                 


Thr Ala Ser Ser Gln Leu Ser Ser Asn Ala Leu Pro Pro Gly Pro Gly 
305                 310                 315                 320 


Leu Glu Gln Arg Asp Gly Thr Gln Gln Ala Val Pro Leu Glu His Pro 
                325                 330                 335     


Ser Ser Pro Trp Gly Leu Asn Leu Thr Glu Lys Ile Lys Lys Ile Lys 
            340                 345                 350         


Ile Val Phe Thr Pro Thr Ile Cys Lys Gln Thr Cys Ala Arg Gly His 
        355                 360                 365             


Cys Ala Asn Ser Cys Glu Arg Gly Asp Thr Thr Thr Leu Tyr Ser Gln 
    370                 375                 380                 


Gly Gly His Gly His Asp Pro Lys Ser Gly Phe Arg Ile Tyr Phe Cys 
385                 390                 395                 400 


Gln Ile Pro Cys Leu Asn Gly Gly Arg Cys Ile Gly Arg Asp Glu Cys 
                405                 410                 415     


Trp Cys Pro Ala Asn Ser Thr Gly Lys Phe Cys His Leu Pro Ile Pro 
            420                 425                 430         


Gln Pro Asp Arg Glu Pro Pro Gly Arg Gly Ser Arg Pro Arg Ala Leu 
        435                 440                 445             


Leu Glu Ala Pro Leu Lys Gln Ser Thr Phe Thr Leu Pro Leu Ser Asn 
    450                 455                 460                 


Gln Leu Ala Ser Val Asn Pro Ser Leu Val Lys Val His Ile His His 
465                 470                 475                 480 


Pro Pro Glu Ala Ser Val Gln Ile His Gln Val Ala Gln Val Arg Gly 
                485                 490                 495     


Gly Val Glu Glu Ala Leu Val Glu Asn Ser Val Glu Thr Arg Pro Pro 
            500                 505                 510         


Pro Trp Leu Pro Ala Ser Pro Gly His Ser Leu Trp Asp Ser Asn Asn 
        515                 520                 525             


Ile Pro Ala Arg Ser Gly Glu Pro Pro Arg Pro Leu Pro Pro Ala Ala 
    530                 535                 540                 


Pro Arg Pro Arg Gly Leu Leu Gly Arg Cys Tyr Leu Asn Thr Val Asn 
545                 550                 555                 560 


Gly Gln Cys Ala Asn Pro Leu Leu Glu Leu Thr Thr Gln Glu Asp Cys 
                565                 570                 575     


Cys Gly Ser Val Gly Ala Phe Trp Gly Val Thr Leu Cys Ala Pro Cys 
            580                 585                 590         


Pro Pro Arg Pro Ala Ser Pro Val Ile Glu Asn Gly Gln Leu Glu Cys 
        595                 600                 605             


Pro Gln Gly Tyr Lys Arg Leu Asn Leu Thr His Cys Gln Asp Ile Asn 
    610                 615                 620                 


Glu Cys Leu Thr Leu Gly Leu Cys Lys Asp Ala Glu Cys Val Asn Thr 
625                 630                 635                 640 


Arg Gly Ser Tyr Leu Cys Thr Cys Arg Pro Gly Leu Met Leu Asp Pro 
                645                 650                 655     


Ser Arg Ser Arg Cys Val Ser Asp Lys Ala Ile Ser Met Leu Gln Gly 
            660                 665                 670         


Leu Cys Tyr Arg Ser Leu Gly Pro Gly Thr Cys Thr Leu Pro Leu Ala 
        675                 680                 685             


Gln Arg Ile Thr Lys Gln Ile Cys Cys Cys Ser Arg Val Gly Lys Ala 
    690                 695                 700                 


Trp Gly Ser Glu Cys Glu Lys Cys Pro Leu Pro Gly Thr Glu Ala Phe 
705                 710                 715                 720 


Arg Glu Ile Cys Pro Ala Gly His Gly Tyr Thr Tyr Ala Ser Ser Asp 
                725                 730                 735     


Ile Arg Leu Ser Met Arg Lys Ala Glu Glu Glu Glu Leu Ala Arg Pro 
            740                 745                 750         


Pro Arg Glu Gln Gly Gln Arg Ser Ser Gly Ala Leu Pro Gly Pro Ala 
        755                 760                 765             


Glu Arg Gln Pro Leu Arg Val Val Thr Asp Thr Trp Leu Glu Ala Gly 
    770                 775                 780                 


Thr Ile Pro Asp Lys Gly Asp Ser Gln Ala Gly Gln Val Thr Thr Ser 
785                 790                 795                 800 


Val Thr His Ala Pro Ala Trp Val Thr Gly Asn Ala Thr Thr Pro Pro 
                805                 810                 815     


Met Pro Glu Gln Gly Ile Ala Glu Ile Gln Glu Glu Gln Val Thr Pro 
            820                 825                 830         


Ser Thr Asp Val Leu Val Thr Leu Ser Thr Pro Gly Ile Asp Arg Cys 
        835                 840                 845             


Ala Ala Gly Ala Thr Asn Val Cys Gly Pro Gly Thr Cys Val Asn Leu 
    850                 855                 860                 


Pro Asp Gly Tyr Arg Cys Val Cys Ser Pro Gly Tyr Gln Leu His Pro 
865                 870                 875                 880 


Ser Gln Ala Tyr Cys Thr Asp Asp Asn Glu Cys Leu Arg Asp Pro Cys 
                885                 890                 895     


Lys Gly Lys Gly Arg Cys Ile Asn Arg Val Gly Ser Tyr Ser Cys Phe 
            900                 905                 910         


Cys Tyr Pro Gly Tyr Thr Leu Ala Thr Ser Gly Ala Thr Gln Glu Cys 
        915                 920                 925             


Gln Asp Ile Asn Glu Cys Glu Gln Pro Gly Val Cys Ser Gly Gly Gln 
    930                 935                 940                 


Cys Thr Asn Thr Glu Gly Ser Tyr His Cys Glu Cys Asp Gln Gly Tyr 
945                 950                 955                 960 


Ile Met Val Arg Lys Gly His Cys Gln Asp Ile Asn Glu Cys Arg His 
                965                 970                 975     


Pro Gly Thr Cys Pro Asp Gly Arg Cys Val Asn Ser Pro Gly Ser Tyr 
            980                 985                 990         


Thr Cys Leu Ala Cys Glu Glu Gly  Tyr Arg Gly Gln Ser  Gly Ser Cys 
        995                 1000                 1005             


Val Asp  Val Asn Glu Cys Leu  Thr Pro Gly Val Cys  Ala His Gly 
    1010                 1015                 1020             


Lys Cys  Thr Asn Leu Glu Gly  Ser Phe Arg Cys Ser  Cys Glu Gln 
    1025                 1030                 1035             


Gly Tyr  Glu Val Thr Ser Asp  Glu Lys Gly Cys Gln  Asp Val Asp 
    1040                 1045                 1050             


Glu Cys  Ala Ser Arg Ala Ser  Cys Pro Thr Gly Leu  Cys Leu Asn 
    1055                 1060                 1065             


Thr Glu  Gly Ser Phe Ala Cys  Ser Ala Cys Glu Asn  Gly Tyr Trp 
    1070                 1075                 1080             


Val Asn  Glu Asp Gly Thr Ala  Cys Glu Asp Leu Asp  Glu Cys Ala 
    1085                 1090                 1095             


Phe Pro  Gly Val Cys Pro Ser  Gly Val Cys Thr Asn  Thr Ala Gly 
    1100                 1105                 1110             


Ser Phe  Ser Cys Lys Asp Cys  Asp Gly Gly Tyr Arg  Pro Ser Pro 
    1115                 1120                 1125             


Leu Gly  Asp Ser Cys Glu Asp  Val Asp Glu Cys Glu  Asp Pro Gln 
    1130                 1135                 1140             


Ser Ser  Cys Leu Gly Gly Glu  Cys Lys Asn Thr Val  Gly Ser Tyr 
    1145                 1150                 1155             


Gln Cys  Leu Cys Pro Gln Gly  Phe Gln Leu Ala Asn  Gly Thr Val 
    1160                 1165                 1170             


Cys Glu  Asp Val Asn Glu Cys  Met Gly Glu Glu His  Cys Ala Pro 
    1175                 1180                 1185             


His Gly  Glu Cys Leu Asn Ser  His Gly Ser Phe Phe  Cys Leu Cys 
    1190                 1195                 1200             


Ala Pro  Gly Phe Val Ser Ala  Glu Gly Gly Thr Ser  Cys Gln Asp 
    1205                 1210                 1215             


Val Asp  Glu Cys Ala Thr Thr  Asp Pro Cys Val Gly  Gly His Cys 
    1220                 1225                 1230             


Val Asn  Thr Glu Gly Ser Phe  Asn Cys Leu Cys Glu  Thr Gly Phe 
    1235                 1240                 1245             


Gln Pro  Ser Pro Glu Ser Gly  Glu Cys Val Asp Ile  Asp Glu Cys 
    1250                 1255                 1260             


Glu Asp  Tyr Gly Asp Pro Val  Cys Gly Thr Trp Lys  Cys Glu Asn 
    1265                 1270                 1275             


Ser Pro  Gly Ser Tyr Arg Cys  Val Leu Gly Cys Gln  Pro Gly Phe 
    1280                 1285                 1290             


His Met  Ala Pro Asn Gly Asp  Cys Ile Asp Ile Asp  Glu Cys Ala 
    1295                 1300                 1305             


Asn Asp  Thr Met Cys Gly Ser  His Gly Phe Cys Asp  Asn Thr Asp 
    1310                 1315                 1320             


Gly Ser  Phe Arg Cys Leu Cys  Asp Gln Gly Phe Glu  Ile Ser Pro 
    1325                 1330                 1335             


Ser Gly  Trp Asp Cys Val Asp  Val Asn Glu Cys Glu  Leu Met Leu 
    1340                 1345                 1350             


Ala Val  Cys Gly Ala Ala Leu  Cys Glu Asn Val Glu  Gly Ser Phe 
    1355                 1360                 1365             


Leu Cys  Leu Cys Ala Ser Asp  Leu Glu Glu Tyr Asp  Ala Gln Glu 
    1370                 1375                 1380             


Gly His  Cys Arg Pro Arg Gly  Ala Gly Gly Gln Ser  Met Ser Glu 
    1385                 1390                 1395             


Ala Pro  Thr Gly Asp His Ala  Pro Ala Pro Thr Arg  Met Asp Cys 
    1400                 1405                 1410             


Tyr Ser  Gly Gln Lys Gly His  Ala Pro Cys Ser Ser  Val Leu Gly 
    1415                 1420                 1425             


Arg Asn  Thr Thr Gln Ala Glu  Cys Cys Cys Thr Gln  Gly Ala Ser 
    1430                 1435                 1440             


Trp Gly  Asp Ala Cys Asp Leu  Cys Pro Ser Glu Asp  Ser Ala Glu 
    1445                 1450                 1455             


Phe Ser  Glu Ile Cys Pro Ser  Gly Lys Gly Tyr Ile  Pro Val Glu 
    1460                 1465                 1470             


Gly Ala  Trp Thr Phe Gly Gln  Thr Met Tyr Thr Asp  Ala Asp Glu 
    1475                 1480                 1485             


Cys Val  Ile Phe Gly Pro Gly  Leu Cys Pro Asn Gly  Arg Cys Leu 
    1490                 1495                 1500             


Asn Thr  Val Pro Gly Tyr Val  Cys Leu Cys Asn Pro  Gly Phe His 
    1505                 1510                 1515             


Tyr Asp  Ala Ser His Lys Lys  Cys Glu Asp His Asp  Glu Cys Gln 
    1520                 1525                 1530             


Asp Leu  Ala Cys Glu Asn Gly  Glu Cys Val Asn Thr  Glu Gly Ser 
    1535                 1540                 1545             


Phe His  Cys Phe Cys Ser Pro  Pro Leu Thr Leu Asp  Leu Ser Gln 
    1550                 1555                 1560             


Gln Arg  Cys Met Asn Ser Thr  Ser Ser Thr Glu Asp  Leu Pro Asp 
    1565                 1570                 1575             


His Asp  Ile His Met Asp Ile  Cys Trp Lys Lys Val  Thr Asn Asp 
    1580                 1585                 1590             


Val Cys  Ser Glu Pro Leu Arg  Gly His Arg Thr Thr  Tyr Thr Glu 
    1595                 1600                 1605             


Cys Cys  Cys Gln Asp Gly Glu  Ala Trp Ser Gln Gln  Cys Ala Leu 
    1610                 1615                 1620             


Cys Pro  Pro Arg Ser Ser Glu  Val Tyr Ala Gln Leu  Cys Asn Val 
    1625                 1630                 1635             


Ala Arg  Ile Glu Ala Glu Arg  Glu Ala Gly Val His  Phe Arg Pro 
    1640                 1645                 1650             


Gly Tyr  Glu Tyr Gly Pro Gly  Pro Asp Asp Leu His  Tyr Ser Ile 
    1655                 1660                 1665             


Tyr Gly  Pro Asp Gly Ala Pro  Phe Tyr Asn Tyr Leu  Gly Pro Glu 
    1670                 1675                 1680             


Asp Thr  Val Pro Glu Pro Ala  Phe Pro Asn Thr Ala  Gly His Ser 
    1685                 1690                 1695             


Ala Asp  Arg Thr Pro Ile Leu  Glu Ser Pro Leu Gln  Pro Ser Glu 
    1700                 1705                 1710             


Leu Gln  Pro His Tyr Val Ala  Ser His Pro Glu Pro  Pro Ala Gly 
    1715                 1720                 1725             


Phe Glu  Gly Leu Gln Ala Glu  Glu Cys Gly Ile Leu  Asn Gly Cys 
    1730                 1735                 1740             


Glu Asn  Gly Arg Cys Val Arg  Val Arg Glu Gly Tyr  Thr Cys Asp 
    1745                 1750                 1755             


Cys Phe  Glu Gly Phe Gln Leu  Asp Ala Ala His Met  Ala Cys Val 
    1760                 1765                 1770             


Asp Val  Asn Glu Cys Asp Asp  Leu Asn Gly Pro Ala  Val Leu Cys 
    1775                 1780                 1785             


Val His  Gly Tyr Cys Glu Asn  Thr Glu Gly Ser Tyr  Arg Cys His 
    1790                 1795                 1800             


Cys Ser  Pro Gly Tyr Val Ala  Glu Ala Gly Pro Pro  His Cys Thr 
    1805                 1810                 1815             


Ala Lys  Glu 
    1820     


<210>  8106
<211>  1769
<212>  PRT
<213>  Homo Sapiens

<400>  8106

Met Arg Pro Arg Thr Lys Ala Arg Ser Pro Gly Arg Ala Leu Arg Asn 
1               5                   10                  15      


Pro Trp Arg Gly Phe Leu Pro Leu Thr Leu Ala Leu Phe Val Gly Ala 
            20                  25                  30          


Gly His Ala Gln Arg Asp Pro Val Gly Arg Tyr Glu Pro Ala Gly Gly 
        35                  40                  45              


Asp Ala Asn Arg Leu Arg Arg Pro Gly Gly Ser Tyr Pro Ala Ala Ala 
    50                  55                  60                  


Ala Ala Lys Val Tyr Ser Leu Phe Arg Glu Gln Asp Ala Pro Val Ala 
65                  70                  75                  80  


Gly Leu Gln Pro Val Glu Arg Ala Gln Pro Gly Trp Gly Ser Pro Arg 
                85                  90                  95      


Arg Pro Thr Glu Ala Glu Ala Arg Arg Pro Ser Arg Ala Gln Gln Ser 
            100                 105                 110         


Arg Arg Val Gln Pro Pro Ala Gln Thr Arg Arg Ser Thr Pro Leu Gly 
        115                 120                 125             


Gln Gln Gln Pro Ala Pro Arg Thr Arg Ala Ala Pro Ala Leu Pro Arg 
    130                 135                 140                 


Leu Gly Thr Pro Gln Arg Ser Gly Ala Ala Pro Pro Thr Pro Pro Arg 
145                 150                 155                 160 


Gly Arg Leu Thr Gly Arg Asn Val Cys Gly Gly Gln Cys Cys Pro Gly 
                165                 170                 175     


Trp Thr Thr Ala Asn Ser Thr Asn His Cys Ile Lys Pro Val Cys Glu 
            180                 185                 190         


Pro Pro Cys Gln Asn Arg Gly Ser Cys Ser Arg Pro Gln Leu Cys Val 
        195                 200                 205             


Cys Arg Ser Gly Phe Arg Gly Ala Arg Cys Glu Glu Val Ile Pro Asp 
    210                 215                 220                 


Glu Glu Phe Asp Pro Gln Asn Ser Arg Leu Ala Pro Arg Arg Trp Ala 
225                 230                 235                 240 


Glu Arg Ser Pro Asn Leu Arg Arg Ser Ser Ala Ala Gly Glu Gly Thr 
                245                 250                 255     


Leu Ala Arg Ala Gln Pro Pro Ala Pro Gln Ser Pro Pro Ala Pro Gln 
            260                 265                 270         


Ser Pro Pro Ala Gly Thr Leu Ser Gly Leu Ser Gln Thr His Pro Ser 
        275                 280                 285             


Gln Gln His Val Gly Leu Ser Arg Thr Val Arg Leu His Pro Thr Ala 
    290                 295                 300                 


Thr Ala Ser Ser Gln Leu Ser Ser Asn Ala Leu Pro Pro Gly Pro Gly 
305                 310                 315                 320 


Leu Glu Gln Arg Asp Gly Thr Gln Gln Ala Val Pro Leu Glu His Pro 
                325                 330                 335     


Ser Ser Pro Trp Gly Leu Asn Leu Thr Glu Lys Ile Lys Lys Ile Lys 
            340                 345                 350         


Ile Val Phe Thr Pro Thr Ile Cys Lys Gln Thr Cys Ala Arg Gly His 
        355                 360                 365             


Cys Ala Asn Ser Cys Glu Arg Gly Asp Thr Thr Thr Leu Tyr Ser Gln 
    370                 375                 380                 


Gly Gly His Gly His Asp Pro Lys Ser Gly Phe Arg Ile Tyr Phe Cys 
385                 390                 395                 400 


Gln Ile Pro Cys Leu Asn Gly Gly Arg Cys Ile Gly Arg Asp Glu Cys 
                405                 410                 415     


Trp Cys Pro Ala Asn Ser Thr Gly Lys Phe Cys His Leu Pro Ile Pro 
            420                 425                 430         


Gln Pro Asp Arg Glu Pro Pro Gly Arg Gly Ser Arg Pro Arg Ala Leu 
        435                 440                 445             


Leu Glu Ala Pro Leu Lys Gln Ser Thr Phe Thr Leu Pro Leu Ser Asn 
    450                 455                 460                 


Gln Leu Ala Ser Val Asn Pro Ser Leu Val Lys Val His Ile His His 
465                 470                 475                 480 


Pro Pro Glu Ala Ser Val Gln Ile His Gln Val Ala Gln Val Arg Gly 
                485                 490                 495     


Gly Val Glu Glu Ala Leu Val Glu Asn Ser Val Glu Thr Arg Pro Pro 
            500                 505                 510         


Pro Trp Leu Pro Ala Ser Pro Gly His Ser Leu Trp Asp Ser Asn Asn 
        515                 520                 525             


Ile Pro Ala Arg Ser Gly Glu Pro Pro Arg Pro Leu Pro Pro Ala Ala 
    530                 535                 540                 


Pro Arg Pro Arg Gly Leu Leu Gly Arg Cys Tyr Leu Asn Thr Val Asn 
545                 550                 555                 560 


Gly Gln Cys Ala Asn Pro Leu Leu Glu Leu Thr Thr Gln Glu Asp Cys 
                565                 570                 575     


Cys Gly Ser Val Gly Ala Phe Trp Gly Val Thr Leu Cys Ala Pro Cys 
            580                 585                 590         


Pro Pro Arg Pro Ala Ser Pro Val Ile Glu Asn Gly Gln Leu Glu Cys 
        595                 600                 605             


Pro Gln Gly Tyr Lys Arg Leu Asn Leu Thr His Cys Gln Asp Ile Asn 
    610                 615                 620                 


Glu Cys Leu Thr Leu Gly Leu Cys Lys Asp Ala Glu Cys Val Asn Thr 
625                 630                 635                 640 


Arg Gly Ser Tyr Leu Cys Thr Cys Arg Pro Gly Leu Met Leu Asp Pro 
                645                 650                 655     


Ser Arg Ser Arg Cys Val Ser Asp Lys Ala Ile Ser Met Leu Gln Gly 
            660                 665                 670         


Leu Cys Tyr Arg Ser Leu Gly Pro Gly Thr Cys Thr Leu Pro Leu Ala 
        675                 680                 685             


Gln Arg Ile Thr Lys Gln Ile Cys Cys Cys Ser Arg Val Gly Lys Ala 
    690                 695                 700                 


Trp Gly Ser Glu Cys Glu Lys Cys Pro Leu Pro Gly Thr Glu Ala Phe 
705                 710                 715                 720 


Arg Glu Ile Cys Pro Ala Gly His Gly Tyr Thr Tyr Ala Ser Ser Asp 
                725                 730                 735     


Ile Arg Leu Ser Met Arg Lys Ala Glu Glu Glu Glu Leu Ala Arg Pro 
            740                 745                 750         


Pro Arg Glu Gln Gly Gln Arg Ser Ser Gly Ala Leu Pro Gly Pro Ala 
        755                 760                 765             


Glu Arg Gln Pro Leu Arg Val Val Thr Asp Thr Trp Leu Glu Ala Gly 
    770                 775                 780                 


Thr Ile Pro Asp Lys Gly Asp Ser Gln Ala Gly Gln Val Thr Thr Ser 
785                 790                 795                 800 


Val Thr His Ala Pro Ala Trp Val Thr Gly Asn Ala Thr Thr Pro Pro 
                805                 810                 815     


Met Pro Glu Gln Gly Ile Ala Glu Ile Gln Glu Glu Gln Val Thr Pro 
            820                 825                 830         


Ser Thr Asp Val Leu Val Thr Leu Ser Thr Pro Gly Ile Asp Arg Cys 
        835                 840                 845             


Ala Ala Gly Ala Thr Asn Val Cys Gly Pro Gly Thr Cys Val Asn Leu 
    850                 855                 860                 


Pro Asp Gly Tyr Arg Cys Val Cys Ser Pro Gly Tyr Gln Leu His Pro 
865                 870                 875                 880 


Ser Gln Ala Tyr Cys Thr Asp Asp Asn Glu Cys Leu Arg Asp Pro Cys 
                885                 890                 895     


Lys Gly Lys Gly Arg Cys Ile Asn Arg Val Gly Ser Tyr Ser Cys Phe 
            900                 905                 910         


Cys Tyr Pro Gly Tyr Thr Leu Ala Thr Ser Gly Ala Thr Gln Glu Cys 
        915                 920                 925             


Gln Asp Ile Asn Glu Cys Glu Gln Pro Gly Val Cys Ser Gly Gly Gln 
    930                 935                 940                 


Cys Thr Asn Thr Glu Gly Ser Tyr His Cys Glu Cys Asp Gln Gly Tyr 
945                 950                 955                 960 


Ile Met Val Arg Lys Gly His Cys Gln Asp Ile Asn Glu Cys Arg His 
                965                 970                 975     


Pro Gly Thr Cys Pro Asp Gly Arg Cys Val Asn Ser Pro Gly Ser Tyr 
            980                 985                 990         


Thr Cys Leu Ala Cys Glu Glu Gly  Tyr Arg Gly Gln Ser  Gly Ser Cys 
        995                 1000                 1005             


Val Asp  Val Asn Glu Cys Leu  Thr Pro Gly Val Cys  Ala His Gly 
    1010                 1015                 1020             


Lys Cys  Thr Asn Leu Glu Gly  Ser Phe Arg Cys Ser  Cys Glu Gln 
    1025                 1030                 1035             


Gly Tyr  Glu Val Thr Ser Asp  Glu Lys Gly Cys Gln  Asp Val Asp 
    1040                 1045                 1050             


Glu Cys  Ala Ser Arg Ala Ser  Cys Pro Thr Gly Leu  Cys Leu Asn 
    1055                 1060                 1065             


Thr Glu  Gly Ser Phe Ala Cys  Ser Ala Cys Glu Asn  Gly Tyr Trp 
    1070                 1075                 1080             


Val Asn  Glu Asp Gly Thr Ala  Cys Glu Asp Leu Asp  Glu Cys Ala 
    1085                 1090                 1095             


Phe Pro  Gly Val Cys Pro Ser  Gly Val Cys Thr Asn  Thr Ala Gly 
    1100                 1105                 1110             


Ser Phe  Ser Cys Lys Asp Cys  Asp Gly Gly Tyr Arg  Pro Ser Pro 
    1115                 1120                 1125             


Leu Gly  Asp Ser Cys Glu Asp  Val Asp Glu Cys Glu  Asp Pro Gln 
    1130                 1135                 1140             


Ser Ser  Cys Leu Gly Gly Glu  Cys Lys Asn Thr Val  Gly Ser Tyr 
    1145                 1150                 1155             


Gln Cys  Leu Cys Pro Gln Gly  Phe Gln Leu Ala Asn  Gly Thr Val 
    1160                 1165                 1170             


Cys Glu  Asp Val Asn Glu Cys  Met Gly Glu Glu His  Cys Ala Pro 
    1175                 1180                 1185             


His Gly  Glu Cys Leu Asn Ser  His Gly Ser Phe Phe  Cys Leu Cys 
    1190                 1195                 1200             


Ala Pro  Gly Phe Val Ser Ala  Glu Gly Gly Thr Ser  Cys Gln Asp 
    1205                 1210                 1215             


Val Asp  Glu Cys Ala Thr Thr  Asp Pro Cys Val Gly  Gly His Cys 
    1220                 1225                 1230             


Val Asn  Thr Glu Gly Ser Phe  Asn Cys Leu Cys Glu  Thr Gly Phe 
    1235                 1240                 1245             


Gln Pro  Ser Pro Glu Ser Gly  Glu Cys Val Asp Ile  Asp Glu Cys 
    1250                 1255                 1260             


Glu Asp  Tyr Gly Asp Pro Val  Cys Gly Thr Trp Lys  Cys Glu Asn 
    1265                 1270                 1275             


Ser Pro  Gly Ser Tyr Arg Cys  Val Leu Gly Cys Gln  Pro Gly Phe 
    1280                 1285                 1290             


His Met  Ala Pro Asn Gly Asp  Cys Ile Asp Ile Asp  Glu Cys Ala 
    1295                 1300                 1305             


Asn Asp  Thr Met Cys Gly Ser  His Gly Phe Cys Asp  Asn Thr Asp 
    1310                 1315                 1320             


Gly Ser  Phe Arg Cys Leu Cys  Asp Gln Gly Phe Glu  Ile Ser Pro 
    1325                 1330                 1335             


Ser Gly  Trp Asp Cys Val Asp  Val Asn Glu Cys Glu  Leu Met Leu 
    1340                 1345                 1350             


Ala Val  Cys Gly Ala Ala Leu  Cys Glu Asn Val Glu  Gly Ser Phe 
    1355                 1360                 1365             


Leu Cys  Leu Cys Ala Ser Asp  Leu Glu Glu Tyr Asp  Ala Gln Glu 
    1370                 1375                 1380             


Gly His  Cys Arg Pro Arg Gly  Ala Gly Gly Gln Ser  Met Ser Glu 
    1385                 1390                 1395             


Ala Pro  Thr Gly Asp His Ala  Pro Ala Pro Thr Arg  Met Asp Cys 
    1400                 1405                 1410             


Tyr Ser  Gly Gln Lys Gly His  Ala Pro Cys Ser Ser  Val Leu Gly 
    1415                 1420                 1425             


Arg Asn  Thr Thr Gln Ala Glu  Cys Cys Cys Thr Gln  Gly Ala Ser 
    1430                 1435                 1440             


Trp Gly  Asp Ala Cys Asp Leu  Cys Pro Ser Glu Asp  Ser Ala Glu 
    1445                 1450                 1455             


Phe Ser  Glu Ile Cys Pro Ser  Gly Lys Gly Tyr Ile  Pro Val Glu 
    1460                 1465                 1470             


Gly Ala  Trp Thr Phe Gly Gln  Thr Met Tyr Thr Asp  Ala Asp Glu 
    1475                 1480                 1485             


Cys Val  Ile Phe Gly Pro Gly  Leu Cys Pro Asn Gly  Arg Cys Leu 
    1490                 1495                 1500             


Asn Thr  Val Pro Gly Tyr Val  Cys Leu Cys Asn Pro  Gly Phe His 
    1505                 1510                 1515             


Tyr Asp  Ala Ser His Lys Lys  Cys Glu Asp His Asp  Glu Cys Gln 
    1520                 1525                 1530             


Asp Leu  Ala Cys Glu Asn Gly  Glu Cys Val Asn Thr  Glu Gly Ser 
    1535                 1540                 1545             


Phe His  Cys Phe Cys Ser Pro  Pro Leu Thr Leu Asp  Leu Ser Gln 
    1550                 1555                 1560             


Gln Arg  Cys Met Asn Ser Thr  Ser Ser Thr Glu Asp  Leu Pro Asp 
    1565                 1570                 1575             


His Asp  Ile His Met Asp Ile  Cys Trp Lys Lys Val  Thr Asn Asp 
    1580                 1585                 1590             


Val Cys  Ser Glu Pro Leu Arg  Gly His Arg Thr Thr  Tyr Thr Glu 
    1595                 1600                 1605             


Cys Cys  Cys Gln Asp Gly Glu  Ala Trp Ser Gln Gln  Cys Ala Leu 
    1610                 1615                 1620             


Cys Pro  Pro Arg Ser Ser Glu  Val Tyr Ala Gln Leu  Cys Asn Val 
    1625                 1630                 1635             


Ala Arg  Ile Glu Ala Glu Arg  Glu Ala Gly Val His  Phe Arg Pro 
    1640                 1645                 1650             


Gly Tyr  Glu Tyr Gly Pro Gly  Pro Asp Asp Leu His  Tyr Ser Ile 
    1655                 1660                 1665             


Tyr Gly  Pro Asp Gly Ala Pro  Phe Tyr Asn Tyr Leu  Gly Pro Glu 
    1670                 1675                 1680             


Asp Thr  Val Pro Glu Pro Ala  Phe Pro Asn Thr Ala  Gly His Ser 
    1685                 1690                 1695             


Ala Asp  Arg Thr Pro Ile Leu  Glu Ser Pro Leu Gln  Pro Ser Glu 
    1700                 1705                 1710             


Leu Gln  Pro His Tyr Val Ala  Ser His Pro Gly Leu  Cys Cys Cys 
    1715                 1720                 1725             


Lys Thr  Gly Glu Glu Val Gly  Thr Lys Ala Val Ser  Leu Pro Ser 
    1730                 1735                 1740             


Pro Pro  Pro Ala Ser His Ile  Ala Ser Arg Ser Pro  Gln Pro Ala 
    1745                 1750                 1755             


Ser Lys  Gly Phe Arg Arg Arg  Ser Ala Ala Ser 
    1760                 1765                 


<210>  8107
<211>  1777
<212>  PRT
<213>  Homo Sapiens

<400>  8107

Met Arg Pro Arg Thr Lys Ala Arg Ser Pro Gly Arg Ala Leu Arg Asn 
1               5                   10                  15      


Pro Trp Arg Gly Phe Leu Pro Leu Thr Leu Ala Leu Phe Val Gly Ala 
            20                  25                  30          


Gly His Ala Gln Arg Asp Pro Val Gly Arg Tyr Glu Pro Ala Gly Gly 
        35                  40                  45              


Asp Ala Asn Arg Leu Arg Arg Pro Gly Gly Ser Tyr Pro Ala Ala Ala 
    50                  55                  60                  


Ala Ala Lys Val Tyr Ser Leu Phe Arg Glu Gln Asp Ala Pro Val Ala 
65                  70                  75                  80  


Gly Leu Gln Pro Val Glu Arg Ala Gln Pro Gly Trp Gly Ser Pro Arg 
                85                  90                  95      


Arg Pro Thr Glu Ala Glu Ala Arg Arg Pro Ser Arg Ala Gln Gln Ser 
            100                 105                 110         


Arg Arg Val Gln Pro Pro Ala Gln Thr Arg Arg Ser Thr Pro Leu Gly 
        115                 120                 125             


Gln Gln Gln Pro Ala Pro Arg Thr Arg Ala Ala Pro Ala Leu Pro Arg 
    130                 135                 140                 


Leu Gly Thr Pro Gln Arg Ser Gly Ala Ala Pro Pro Thr Pro Pro Arg 
145                 150                 155                 160 


Gly Arg Leu Thr Gly Arg Asn Val Cys Gly Gly Gln Cys Cys Pro Gly 
                165                 170                 175     


Trp Thr Thr Ala Asn Ser Thr Asn His Cys Ile Lys Pro Val Cys Glu 
            180                 185                 190         


Pro Pro Cys Gln Asn Arg Gly Ser Cys Ser Arg Pro Gln Leu Cys Val 
        195                 200                 205             


Cys Arg Ser Gly Phe Arg Gly Ala Arg Cys Glu Glu Val Ile Pro Asp 
    210                 215                 220                 


Glu Glu Phe Asp Pro Gln Asn Ser Arg Leu Ala Pro Arg Arg Trp Ala 
225                 230                 235                 240 


Glu Arg Ser Pro Asn Leu Arg Arg Ser Ser Ala Ala Gly Glu Gly Thr 
                245                 250                 255     


Leu Ala Arg Ala Gln Pro Pro Ala Pro Gln Ser Pro Pro Ala Pro Gln 
            260                 265                 270         


Ser Pro Pro Ala Gly Thr Leu Ser Gly Leu Ser Gln Thr His Pro Ser 
        275                 280                 285             


Gln Gln His Val Gly Leu Ser Arg Thr Val Arg Leu His Pro Thr Ala 
    290                 295                 300                 


Thr Ala Ser Ser Gln Leu Ser Ser Asn Ala Leu Pro Pro Gly Pro Gly 
305                 310                 315                 320 


Leu Glu Gln Arg Asp Gly Thr Gln Gln Ala Val Pro Leu Glu His Pro 
                325                 330                 335     


Ser Ser Pro Trp Gly Leu Asn Leu Thr Glu Lys Ile Lys Lys Ile Lys 
            340                 345                 350         


Ile Val Phe Thr Pro Thr Ile Cys Lys Gln Thr Cys Ala Arg Gly His 
        355                 360                 365             


Cys Ala Asn Ser Cys Glu Arg Gly Asp Thr Thr Thr Leu Tyr Ser Gln 
    370                 375                 380                 


Gly Gly His Gly His Asp Pro Lys Ser Gly Phe Arg Ile Tyr Phe Cys 
385                 390                 395                 400 


Gln Ile Pro Cys Leu Asn Gly Gly Arg Cys Ile Gly Arg Asp Glu Cys 
                405                 410                 415     


Trp Cys Pro Ala Asn Ser Thr Gly Lys Phe Cys His Leu Pro Ile Pro 
            420                 425                 430         


Gln Pro Asp Arg Glu Pro Pro Gly Arg Gly Ser Arg Pro Arg Ala Leu 
        435                 440                 445             


Leu Glu Ala Pro Leu Lys Gln Ser Thr Phe Thr Leu Pro Leu Ser Asn 
    450                 455                 460                 


Gln Leu Ala Ser Val Asn Pro Ser Leu Val Lys Val His Ile His His 
465                 470                 475                 480 


Pro Pro Glu Ala Ser Val Gln Ile His Gln Val Ala Gln Val Arg Gly 
                485                 490                 495     


Gly Val Glu Glu Ala Leu Val Glu Asn Ser Val Glu Thr Arg Pro Pro 
            500                 505                 510         


Pro Trp Leu Pro Ala Ser Pro Gly His Ser Leu Trp Asp Ser Asn Asn 
        515                 520                 525             


Ile Pro Ala Arg Ser Gly Glu Pro Pro Arg Pro Leu Pro Pro Ala Ala 
    530                 535                 540                 


Pro Arg Pro Arg Gly Leu Leu Gly Arg Cys Tyr Leu Asn Thr Val Asn 
545                 550                 555                 560 


Gly Gln Cys Ala Asn Pro Leu Leu Glu Leu Thr Thr Gln Glu Asp Cys 
                565                 570                 575     


Cys Gly Ser Val Gly Ala Phe Trp Gly Val Thr Leu Cys Ala Pro Cys 
            580                 585                 590         


Pro Pro Arg Pro Ala Ser Pro Val Ile Glu Asn Gly Gln Leu Glu Cys 
        595                 600                 605             


Pro Gln Gly Tyr Lys Arg Leu Asn Leu Thr His Cys Gln Asp Ile Asn 
    610                 615                 620                 


Glu Cys Leu Thr Leu Gly Leu Cys Lys Asp Ala Glu Cys Val Asn Thr 
625                 630                 635                 640 


Arg Gly Ser Tyr Leu Cys Thr Cys Arg Pro Gly Leu Met Leu Asp Pro 
                645                 650                 655     


Ser Arg Ser Arg Cys Val Ser Asp Lys Ala Ile Ser Met Leu Gln Gly 
            660                 665                 670         


Leu Cys Tyr Arg Ser Leu Gly Pro Gly Thr Cys Thr Leu Pro Leu Ala 
        675                 680                 685             


Gln Arg Ile Thr Lys Gln Ile Cys Cys Cys Ser Arg Val Gly Lys Ala 
    690                 695                 700                 


Trp Gly Ser Glu Cys Glu Lys Cys Pro Leu Pro Gly Thr Glu Ala Phe 
705                 710                 715                 720 


Arg Glu Ile Cys Pro Ala Gly His Gly Tyr Thr Tyr Ala Ser Ser Asp 
                725                 730                 735     


Ile Arg Leu Ser Met Arg Lys Ala Glu Glu Glu Glu Leu Ala Arg Pro 
            740                 745                 750         


Pro Arg Glu Gln Gly Gln Arg Ser Ser Gly Ala Leu Pro Gly Pro Ala 
        755                 760                 765             


Glu Arg Gln Pro Leu Arg Val Val Thr Asp Thr Trp Leu Glu Ala Gly 
    770                 775                 780                 


Thr Ile Pro Asp Lys Gly Asp Ser Gln Ala Gly Gln Val Thr Thr Ser 
785                 790                 795                 800 


Val Thr His Ala Pro Ala Trp Val Thr Gly Asn Ala Thr Thr Pro Pro 
                805                 810                 815     


Met Pro Glu Gln Gly Ile Ala Glu Ile Gln Glu Glu Gln Val Thr Pro 
            820                 825                 830         


Ser Thr Asp Val Leu Val Thr Leu Ser Thr Pro Gly Ile Asp Arg Cys 
        835                 840                 845             


Ala Ala Gly Ala Thr Asn Val Cys Gly Pro Gly Thr Cys Val Asn Leu 
    850                 855                 860                 


Pro Asp Gly Tyr Arg Cys Val Cys Ser Pro Gly Tyr Gln Leu His Pro 
865                 870                 875                 880 


Ser Gln Ala Tyr Cys Thr Asp Asp Asn Glu Cys Leu Arg Asp Pro Cys 
                885                 890                 895     


Lys Gly Lys Gly Arg Cys Ile Asn Arg Val Gly Ser Tyr Ser Cys Phe 
            900                 905                 910         


Cys Tyr Pro Gly Tyr Thr Leu Ala Thr Ser Gly Ala Thr Gln Glu Cys 
        915                 920                 925             


Gln Asp Ile Asn Glu Cys Glu Gln Pro Gly Val Cys Ser Gly Gly Gln 
    930                 935                 940                 


Cys Thr Asn Thr Glu Gly Ser Tyr His Cys Glu Cys Asp Gln Gly Tyr 
945                 950                 955                 960 


Ile Met Val Arg Lys Gly His Cys Gln Asp Ile Asn Glu Cys Arg His 
                965                 970                 975     


Pro Gly Thr Cys Pro Asp Gly Arg Cys Val Asn Ser Pro Gly Ser Tyr 
            980                 985                 990         


Thr Cys Leu Ala Cys Glu Glu Gly  Tyr Arg Gly Gln Ser  Gly Ser Cys 
        995                 1000                 1005             


Val Asp  Val Asn Glu Cys Leu  Thr Pro Gly Val Cys  Ala His Gly 
    1010                 1015                 1020             


Lys Cys  Thr Asn Leu Glu Gly  Ser Phe Arg Cys Ser  Cys Glu Gln 
    1025                 1030                 1035             


Gly Tyr  Glu Val Thr Ser Asp  Glu Lys Gly Cys Gln  Asp Val Asp 
    1040                 1045                 1050             


Glu Cys  Ala Ser Arg Ala Ser  Cys Pro Thr Gly Leu  Cys Leu Asn 
    1055                 1060                 1065             


Thr Glu  Gly Ser Phe Ala Cys  Ser Ala Cys Glu Asn  Gly Tyr Trp 
    1070                 1075                 1080             


Val Asn  Glu Asp Gly Thr Ala  Cys Glu Asp Leu Asp  Glu Cys Ala 
    1085                 1090                 1095             


Phe Pro  Gly Val Cys Pro Ser  Gly Val Cys Thr Asn  Thr Ala Gly 
    1100                 1105                 1110             


Ser Phe  Ser Cys Lys Asp Cys  Asp Gly Gly Tyr Arg  Pro Ser Pro 
    1115                 1120                 1125             


Leu Gly  Asp Ser Cys Glu Asp  Val Asp Glu Cys Glu  Asp Pro Gln 
    1130                 1135                 1140             


Ser Ser  Cys Leu Gly Gly Glu  Cys Lys Asn Thr Val  Gly Ser Tyr 
    1145                 1150                 1155             


Gln Cys  Leu Cys Pro Gln Gly  Phe Gln Leu Ala Asn  Gly Thr Val 
    1160                 1165                 1170             


Cys Glu  Asp Val Asn Glu Cys  Met Gly Glu Glu His  Cys Ala Pro 
    1175                 1180                 1185             


His Gly  Glu Cys Leu Asn Ser  His Gly Ser Phe Phe  Cys Leu Cys 
    1190                 1195                 1200             


Ala Pro  Gly Phe Val Ser Ala  Glu Gly Gly Thr Ser  Cys Gln Asp 
    1205                 1210                 1215             


Val Asp  Glu Cys Ala Thr Thr  Asp Pro Cys Val Gly  Gly His Cys 
    1220                 1225                 1230             


Val Asn  Thr Glu Gly Ser Phe  Asn Cys Leu Cys Glu  Thr Gly Phe 
    1235                 1240                 1245             


Gln Pro  Ser Pro Glu Ser Gly  Glu Cys Val Asp Ile  Asp Glu Cys 
    1250                 1255                 1260             


Ala Asn  Asp Thr Met Cys Gly  Ser His Gly Phe Cys  Asp Asn Thr 
    1265                 1270                 1275             


Asp Gly  Ser Phe Arg Cys Leu  Cys Asp Gln Gly Phe  Glu Ile Ser 
    1280                 1285                 1290             


Pro Ser  Gly Trp Asp Cys Val  Asp Val Asn Glu Cys  Glu Leu Met 
    1295                 1300                 1305             


Leu Ala  Val Cys Gly Ala Ala  Leu Cys Glu Asn Val  Glu Gly Ser 
    1310                 1315                 1320             


Phe Leu  Cys Leu Cys Ala Ser  Asp Leu Glu Glu Tyr  Asp Ala Gln 
    1325                 1330                 1335             


Glu Gly  His Cys Arg Pro Arg  Gly Ala Gly Gly Gln  Ser Met Ser 
    1340                 1345                 1350             


Glu Ala  Pro Thr Gly Asp His  Ala Pro Ala Pro Thr  Arg Met Asp 
    1355                 1360                 1365             


Cys Tyr  Ser Gly Gln Lys Gly  His Ala Pro Cys Ser  Ser Val Leu 
    1370                 1375                 1380             


Gly Arg  Asn Thr Thr Gln Ala  Glu Cys Cys Cys Thr  Gln Gly Ala 
    1385                 1390                 1395             


Ser Trp  Gly Asp Ala Cys Asp  Leu Cys Pro Ser Glu  Asp Ser Ala 
    1400                 1405                 1410             


Glu Phe  Ser Glu Ile Cys Pro  Ser Gly Lys Gly Tyr  Ile Pro Val 
    1415                 1420                 1425             


Glu Gly  Ala Trp Thr Phe Gly  Gln Thr Met Tyr Thr  Asp Ala Asp 
    1430                 1435                 1440             


Glu Cys  Val Ile Phe Gly Pro  Gly Leu Cys Pro Asn  Gly Arg Cys 
    1445                 1450                 1455             


Leu Asn  Thr Val Pro Gly Tyr  Val Cys Leu Cys Asn  Pro Gly Phe 
    1460                 1465                 1470             


His Tyr  Asp Ala Ser His Lys  Lys Cys Glu Asp His  Asp Glu Cys 
    1475                 1480                 1485             


Gln Asp  Leu Ala Cys Glu Asn  Gly Glu Cys Val Asn  Thr Glu Gly 
    1490                 1495                 1500             


Ser Phe  His Cys Phe Cys Ser  Pro Pro Leu Thr Leu  Asp Leu Ser 
    1505                 1510                 1515             


Gln Gln  Arg Cys Met Asn Ser  Thr Ser Ser Thr Glu  Asp Leu Pro 
    1520                 1525                 1530             


Asp His  Asp Ile His Met Asp  Ile Cys Trp Lys Lys  Val Thr Asn 
    1535                 1540                 1545             


Asp Val  Cys Ser Glu Pro Leu  Arg Gly His Arg Thr  Thr Tyr Thr 
    1550                 1555                 1560             


Glu Cys  Cys Cys Gln Asp Gly  Glu Ala Trp Ser Gln  Gln Cys Ala 
    1565                 1570                 1575             


Leu Cys  Pro Pro Arg Ser Ser  Glu Val Tyr Ala Gln  Leu Cys Asn 
    1580                 1585                 1590             


Val Ala  Arg Ile Glu Ala Glu  Arg Glu Ala Gly Val  His Phe Arg 
    1595                 1600                 1605             


Pro Gly  Tyr Glu Tyr Gly Pro  Gly Pro Asp Asp Leu  His Tyr Ser 
    1610                 1615                 1620             


Ile Tyr  Gly Pro Asp Gly Ala  Pro Phe Tyr Asn Tyr  Leu Gly Pro 
    1625                 1630                 1635             


Glu Asp  Thr Val Pro Glu Pro  Ala Phe Pro Asn Thr  Ala Gly His 
    1640                 1645                 1650             


Ser Ala  Asp Arg Thr Pro Ile  Leu Glu Ser Pro Leu  Gln Pro Ser 
    1655                 1660                 1665             


Glu Leu  Gln Pro His Tyr Val  Ala Ser His Pro Glu  Pro Pro Ala 
    1670                 1675                 1680             


Gly Phe  Glu Gly Leu Gln Ala  Glu Glu Cys Gly Ile  Leu Asn Gly 
    1685                 1690                 1695             


Cys Glu  Asn Gly Arg Cys Val  Arg Val Arg Glu Gly  Tyr Thr Cys 
    1700                 1705                 1710             


Asp Cys  Phe Glu Gly Phe Gln  Leu Asp Ala Ala His  Met Ala Cys 
    1715                 1720                 1725             


Val Asp  Val Asn Glu Cys Asp  Asp Leu Asn Gly Pro  Ala Val Leu 
    1730                 1735                 1740             


Cys Val  His Gly Tyr Cys Glu  Asn Thr Glu Gly Ser  Tyr Arg Cys 
    1745                 1750                 1755             


His Cys  Ser Pro Gly Tyr Val  Ala Glu Ala Gly Pro  Pro His Cys 
    1760                 1765                 1770             


Thr Ala  Lys Glu 
    1775         


<210>  8108
<211>  233
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8108

Xaa Thr Glu Gly Ser Phe Ala Cys Ser Ala Cys Glu Asn Gly Tyr Trp 
1               5                   10                  15      


Val Asn Glu Asp Gly Thr Ala Cys Glu Asp Leu Asp Glu Cys Ala Phe 
            20                  25                  30          


Pro Gly Val Cys Pro Ser Gly Val Cys Thr Asn Thr Ala Gly Ser Phe 
        35                  40                  45              


Ser Cys Lys Asp Cys Asp Gly Gly Tyr Arg Pro Ser Pro Leu Gly Asp 
    50                  55                  60                  


Ser Cys Glu Asp Val Asp Glu Cys Glu Asp Pro Gln Ser Ser Cys Leu 
65                  70                  75                  80  


Gly Gly Glu Cys Lys Asn Thr Val Gly Ser Tyr Gln Cys Leu Cys Pro 
                85                  90                  95      


Gln Gly Phe Gln Leu Ala Asn Gly Thr Val Cys Glu Asp Val Asn Glu 
            100                 105                 110         


Cys Met Gly Glu Glu His Cys Ala Pro His Gly Glu Cys Leu Asn Ser 
        115                 120                 125             


His Gly Ser Phe Phe Cys Leu Cys Ala Pro Gly Phe Val Ser Ala Glu 
    130                 135                 140                 


Gly Gly Thr Ser Cys Gln Asp Ile Asp Glu Cys Glu Asp Tyr Gly Asp 
145                 150                 155                 160 


Pro Val Cys Gly Thr Trp Lys Cys Glu Asn Ser Pro Gly Ser Tyr Arg 
                165                 170                 175     


Cys Val Leu Gly Cys Gln Pro Gly Phe His Met Ala Pro Asn Gly Asp 
            180                 185                 190         


Cys Ile Asp Ile Asp Glu Cys Ala Asn Asp Thr Met Cys Gly Ser His 
        195                 200                 205             


Gly Phe Cys Asp Asn Thr Asp Gly Ser Phe Arg Cys Leu Cys Asp Gln 
    210                 215                 220                 


Gly Phe Glu Ile Ser Pro Ser Gly Trp 
225                 230             


<210>  8109
<211>  144
<212>  PRT
<213>  Homo Sapiens

<400>  8109

Phe Gln Asp Thr Leu Pro Lys Gln Pro Cys Gly Ser Asn Pro Leu Pro 
1               5                   10                  15      


Gly Leu Thr Lys Gln Glu Asp Cys Cys Gly Ser Ile Gly Thr Ala Trp 
            20                  25                  30          


Gly Gln Ser Lys Cys His Lys Cys Pro Gln Leu Gln Tyr Thr Gly Val 
        35                  40                  45              


Gln Lys Pro Gly Pro Val Arg Gly Glu Val Gly Ala Asp Cys Pro Gln 
    50                  55                  60                  


Gly Tyr Lys Arg Leu Asn Ser Thr His Cys Gln Ala Asp Lys Pro Glu 
65                  70                  75                  80  


Glu Lys Ser Leu Cys Phe Arg Leu Val Ser Pro Glu His Gln Cys Gln 
                85                  90                  95      


His Pro Leu Thr Thr Arg Leu Thr Arg Gln Leu Cys Cys Cys Ser Val 
            100                 105                 110         


Gly Lys Ala Trp Gly Ala Arg Cys Gln Arg Cys Pro Thr Asp Gly Thr 
        115                 120                 125             


Ala Ala Phe Lys Glu Ile Cys Pro Ala Gly Lys Gly Tyr His Ile Leu 
    130                 135                 140                 


<210>  8110
<211>  140
<212>  PRT
<213>  Homo Sapiens

<400>  8110

Leu Asn Glu Cys Ala Lys Pro His Leu Cys Gly Asp Gly Gly Phe Cys 
1               5                   10                  15      


Ile Asn Phe Pro Gly His Tyr Lys Cys Asn Cys Tyr Pro Gly Tyr Arg 
            20                  25                  30          


Leu Lys Ala Ser Arg Pro Pro Val Cys Glu Asp Ile Asp Glu Cys Arg 
        35                  40                  45              


Asp Pro Ser Ser Cys Pro Asp Gly Lys Cys Glu Asn Lys Pro Gly Ser 
    50                  55                  60                  


Phe Lys Cys Ile Ala Cys Gln Pro Gly Tyr Arg Ser Gln Gly Gly Gly 
65                  70                  75                  80  


Ala Cys Arg Asp Val Asn Glu Cys Ala Glu Gly Ser Pro Cys Ser Pro 
                85                  90                  95      


Gly Trp Cys Glu Asn Leu Pro Gly Ser Phe Arg Cys Thr Cys Ala Gln 
            100                 105                 110         


Gly Tyr Ala Pro Ala Pro Asp Gly Arg Ser Cys Leu Gly Glu Arg Gln 
        115                 120                 125             


His Pro Arg Pro Gly Pro Pro Pro Pro Pro Thr Arg 
    130                 135                 140 


<210>  8111
<211>  124
<212>  PRT
<213>  Homo Sapiens

<400>  8111

Met Glu Arg Ala Pro Glu Arg Arg Asp Val Cys Trp Ser Gln Arg Gly 
1               5                   10                  15      


Glu Asp Gly Met Cys Ala Gly Pro Leu Ala Gly Pro Ala Leu Thr Phe 
            20                  25                  30          


Asp Asp Cys Cys Cys Arg Gln Gly Arg Gly Trp Gly Ala Gln Cys Arg 
        35                  40                  45              


Pro Cys Pro Pro Arg Gly Ala Gly Ser His Cys Pro Thr Ser Gln Ser 
    50                  55                  60                  


Glu Ser Asn Ser Phe Trp Asp Thr Ser Pro Leu Leu Leu Gly Lys Pro 
65                  70                  75                  80  


Pro Arg Asp Glu Asp Ser Ser Glu Glu Asp Ser Asp Glu Cys Arg Cys 
                85                  90                  95      


Val Ser Gly Arg Cys Val Pro Arg Pro Gly Gly Ala Val Cys Glu Cys 
            100                 105                 110         


Pro Gly Gly Phe Gln Leu Asp Ala Ser Arg Ala Arg 
        115                 120                 


<210>  8112
<211>  306
<212>  PRT
<213>  Homo Sapiens

<400>  8112

Met Leu Phe Gly Ser Glu Ile Cys Lys Glu Gly Lys Cys Val Asn Thr 
1               5                   10                  15      


Gln Pro Gly Tyr Glu Cys Tyr Cys Lys Gln Gly Phe Tyr Tyr Asp Gly 
            20                  25                  30          


Asn Leu Leu Glu Cys Val Asp Val Asp Glu Cys Leu Asp Glu Ser Asn 
        35                  40                  45              


Cys Arg Asn Gly Val Cys Glu Asn Thr Arg Gly Gly Tyr Arg Cys Ala 
    50                  55                  60                  


Cys Thr Pro Pro Ala Glu Tyr Ser Pro Ala Gln Arg Gln Cys Leu Ser 
65                  70                  75                  80  


Pro Glu Glu Met Asp Val Asp Glu Cys Gln Asp Pro Ala Ala Cys Arg 
                85                  90                  95      


Pro Gly Arg Cys Val Asn Leu Pro Gly Ser Tyr Arg Cys Glu Cys Arg 
            100                 105                 110         


Pro Pro Trp Val Pro Gly Pro Ser Gly Arg Asp Cys Gln Leu Pro Glu 
        115                 120                 125             


Ser Pro Ala Glu Arg Ala Pro Glu Arg Arg Asp Val Cys Trp Ser Gln 
    130                 135                 140                 


Arg Gly Glu Asp Gly Met Cys Ala Gly Pro Leu Ala Gly Pro Ala Leu 
145                 150                 155                 160 


Thr Phe Asp Asp Cys Cys Cys Arg Gln Gly Arg Gly Trp Gly Ala Gln 
                165                 170                 175     


Cys Arg Pro Cys Pro Pro Arg Gly Ala Gly Ser His Cys Pro Thr Ser 
            180                 185                 190         


Gln Ser Glu Ser Asn Ser Phe Trp Asp Thr Ser Pro Leu Leu Leu Gly 
        195                 200                 205             


Lys Pro Pro Arg Asp Glu Asp Ser Ser Glu Glu Asp Ser Asp Glu Cys 
    210                 215                 220                 


Arg Cys Val Ser Gly Arg Cys Val Pro Arg Pro Gly Gly Ala Val Cys 
225                 230                 235                 240 


Glu Cys Pro Gly Gly Phe Gln Leu Asp Ala Ser Arg Ala Arg Cys Val 
                245                 250                 255     


Asp Ile Asp Glu Cys Arg Glu Leu Asn Gln Arg Gly Leu Leu Cys Lys 
            260                 265                 270         


Ser Glu Arg Cys Val Asn Thr Ser Gly Ser Phe Arg Cys Val Cys Lys 
        275                 280                 285             


Ala Gly Phe Ala Arg Ser Arg Pro His Gly Ala Cys Val Pro Gln Arg 
    290                 295                 300                 


Arg Arg 
305     


<210>  8113
<211>  222
<212>  PRT
<213>  Homo Sapiens

<400>  8113

Met Leu Phe Gly Ser Glu Ile Cys Lys Glu Gly Lys Cys Val Asn Thr 
1               5                   10                  15      


Gln Pro Gly Tyr Glu Cys Tyr Cys Lys Gln Gly Phe Tyr Tyr Asp Gly 
            20                  25                  30          


Asn Leu Leu Glu Cys Val Asp Val Asp Glu Cys Leu Asp Glu Ser Asn 
        35                  40                  45              


Cys Arg Asn Gly Val Cys Glu Asn Thr Arg Gly Gly Tyr Arg Cys Ala 
    50                  55                  60                  


Cys Thr Pro Pro Ala Glu Tyr Ser Pro Ala Gln Arg Gln Cys Leu Ser 
65                  70                  75                  80  


Pro Glu Glu Met Glu Arg Ala Pro Glu Arg Arg Asp Val Cys Trp Ser 
                85                  90                  95      


Gln Arg Gly Glu Asp Gly Met Cys Ala Gly Pro Leu Ala Gly Pro Ala 
            100                 105                 110         


Leu Thr Phe Asp Asp Cys Cys Cys Arg Gln Gly Arg Gly Trp Gly Ala 
        115                 120                 125             


Gln Cys Arg Pro Cys Pro Pro Arg Gly Ala Gly Ser His Cys Pro Thr 
    130                 135                 140                 


Ser Gln Ser Glu Ser Asn Ser Phe Trp Asp Thr Ser Pro Leu Leu Leu 
145                 150                 155                 160 


Gly Lys Pro Pro Arg Asp Glu Asp Ser Ser Glu Glu Asp Ser Asp Glu 
                165                 170                 175     


Cys Arg Cys Val Ser Gly Arg Cys Val Pro Arg Pro Gly Gly Ala Val 
            180                 185                 190         


Cys Glu Cys Pro Gly Gly Phe Gln Leu Asp Ala Ser Arg Ala Arg Cys 
        195                 200                 205             


Val Asp Ile Asp Glu Cys Arg Glu Leu Asn Gln Arg Gly Leu 
    210                 215                 220         


<210>  8114
<211>  259
<212>  PRT
<213>  Homo Sapiens

<400>  8114

Met Leu Phe Gly Ser Glu Ile Cys Lys Glu Gly Lys Cys Val Asn Thr 
1               5                   10                  15      


Gln Pro Gly Tyr Glu Cys Tyr Cys Lys Gln Gly Phe Tyr Tyr Asp Gly 
            20                  25                  30          


Asn Leu Leu Glu Cys Val Asp Val Asp Glu Cys Leu Asp Glu Ser Asn 
        35                  40                  45              


Cys Arg Asn Gly Val Cys Glu Asn Thr Arg Gly Gly Tyr Arg Cys Ala 
    50                  55                  60                  


Cys Thr Pro Pro Ala Glu Tyr Ser Pro Ala Gln Arg Gln Cys Leu Ser 
65                  70                  75                  80  


Pro Glu Glu Met Glu Arg Ala Pro Glu Arg Arg Asp Val Cys Trp Ser 
                85                  90                  95      


Gln Arg Gly Glu Asp Gly Met Cys Ala Gly Pro Leu Ala Gly Pro Ala 
            100                 105                 110         


Leu Thr Phe Asp Asp Cys Cys Cys Arg Gln Gly Arg Gly Trp Gly Ala 
        115                 120                 125             


Gln Cys Arg Pro Cys Pro Pro Arg Gly Ala Gly Ser His Cys Pro Thr 
    130                 135                 140                 


Ser Gln Ser Glu Ser Asn Ser Phe Trp Asp Thr Ser Pro Leu Leu Leu 
145                 150                 155                 160 


Gly Lys Pro Pro Arg Asp Glu Asp Ser Ser Glu Glu Asp Ser Asp Glu 
                165                 170                 175     


Cys Arg Cys Val Ser Gly Arg Cys Val Pro Arg Pro Gly Gly Ala Val 
            180                 185                 190         


Cys Glu Cys Pro Gly Gly Phe Gln Leu Asp Ala Ser Arg Ala Arg Cys 
        195                 200                 205             


Val Asp Ile Asp Glu Cys Arg Glu Leu Asn Gln Arg Gly Leu Leu Cys 
    210                 215                 220                 


Lys Ser Glu Arg Cys Val Asn Thr Ser Gly Ser Phe Arg Cys Val Cys 
225                 230                 235                 240 


Lys Ala Gly Phe Ala Arg Ser Arg Pro His Gly Ala Cys Val Pro Gln 
                245                 250                 255     


Arg Arg Arg 
            


<210>  8115
<211>  733
<212>  PRT
<213>  Homo Sapiens

<400>  8115

Met Pro Ala Glu Thr Asp Glu Cys Arg Leu Asn Gln Asn Ile Cys Gly 
1               5                   10                  15      


His Gly Glu Cys Val Pro Gly Pro Pro Asp Tyr Ser Cys His Cys Asn 
            20                  25                  30          


Pro Gly Tyr Arg Ser His Pro Gln His Arg Tyr Cys Val Asp Val Asn 
        35                  40                  45              


Glu Cys Glu Ala Glu Pro Cys Gly Pro Gly Arg Gly Ile Cys Met Asn 
    50                  55                  60                  


Thr Gly Gly Ser Tyr Asn Cys His Cys Asn Arg Gly Tyr Arg Leu His 
65                  70                  75                  80  


Val Gly Ala Gly Gly Arg Ser Cys Val Asp Leu Asn Glu Cys Ala Lys 
                85                  90                  95      


Pro His Leu Cys Gly Asp Gly Gly Phe Cys Ile Asn Phe Pro Gly His 
            100                 105                 110         


Tyr Lys Cys Asn Cys Tyr Pro Gly Tyr Arg Leu Lys Ala Ser Arg Pro 
        115                 120                 125             


Pro Val Cys Glu Asp Ile Asp Glu Cys Arg Asp Pro Ser Ser Cys Pro 
    130                 135                 140                 


Asp Gly Lys Cys Glu Asn Lys Pro Gly Ser Phe Lys Cys Ile Ala Cys 
145                 150                 155                 160 


Gln Pro Gly Tyr Arg Ser Gln Gly Gly Gly Ala Cys Arg Asp Val Asn 
                165                 170                 175     


Glu Cys Ala Glu Gly Ser Pro Cys Ser Pro Gly Trp Cys Glu Asn Leu 
            180                 185                 190         


Pro Gly Ser Phe Arg Cys Thr Cys Ala Gln Gly Tyr Ala Pro Ala Pro 
        195                 200                 205             


Asp Gly Arg Ser Cys Leu Asp Val Asp Glu Cys Glu Ala Gly Asp Val 
    210                 215                 220                 


Cys Asp Asn Gly Ile Cys Ser Asn Thr Pro Gly Ser Phe Gln Cys Gln 
225                 230                 235                 240 


Cys Leu Ser Gly Tyr His Leu Ser Arg Asp Arg Ser His Cys Glu Asp 
                245                 250                 255     


Ile Asp Glu Cys Asp Phe Pro Ala Ala Cys Ile Gly Gly Asp Cys Ile 
            260                 265                 270         


Asn Thr Asn Gly Ser Tyr Arg Cys Leu Cys Pro Gln Gly His Arg Leu 
        275                 280                 285             


Val Gly Gly Arg Lys Cys Gln Asp Ile Asp Glu Cys Ser Gln Asp Pro 
    290                 295                 300                 


Ser Leu Cys Leu Pro His Gly Ala Cys Lys Asn Leu Gln Gly Ser Tyr 
305                 310                 315                 320 


Val Cys Val Cys Asp Glu Gly Phe Thr Pro Thr Gln Asp Gln His Gly 
                325                 330                 335     


Cys Glu Glu Val Glu Gln Pro His His Lys Lys Glu Cys Tyr Leu Asn 
            340                 345                 350         


Phe Asp Asp Thr Val Phe Cys Asp Ser Val Leu Ala Thr Asn Val Thr 
        355                 360                 365             


Gln Gln Glu Cys Cys Cys Ser Leu Gly Ala Gly Trp Gly Asp His Cys 
    370                 375                 380                 


Glu Ile Tyr Pro Cys Pro Val Tyr Ser Ser Ala Glu Phe His Ser Leu 
385                 390                 395                 400 


Cys Pro Asp Gly Lys Gly Tyr Thr Gln Asp Asn Asn Ile Val Asn Tyr 
                405                 410                 415     


Gly Ile Pro Ala His Arg Asp Ile Asp Glu Cys Met Leu Phe Gly Ser 
            420                 425                 430         


Glu Ile Cys Lys Glu Gly Lys Cys Val Asn Thr Gln Pro Gly Tyr Glu 
        435                 440                 445             


Cys Tyr Cys Lys Gln Gly Phe Tyr Tyr Asp Gly Asn Leu Leu Glu Cys 
    450                 455                 460                 


Val Asp Val Asp Glu Cys Leu Asp Glu Ser Asn Cys Arg Asn Gly Val 
465                 470                 475                 480 


Cys Glu Asn Thr Arg Gly Gly Tyr Arg Cys Ala Cys Thr Pro Pro Ala 
                485                 490                 495     


Glu Tyr Ser Pro Ala Gln Arg Gln Cys Leu Ser Pro Glu Glu Met Asp 
            500                 505                 510         


Val Asp Glu Cys Gln Asp Pro Ala Ala Cys Arg Pro Gly Arg Cys Val 
        515                 520                 525             


Asn Leu Pro Gly Ser Tyr Arg Cys Glu Cys Arg Pro Pro Trp Val Pro 
    530                 535                 540                 


Gly Pro Ser Gly Arg Asp Cys Gln Leu Pro Glu Ser Pro Ala Glu Arg 
545                 550                 555                 560 


Ala Pro Glu Arg Arg Asp Val Cys Trp Ser Gln Arg Gly Glu Asp Gly 
                565                 570                 575     


Met Cys Ala Gly Pro Leu Ala Gly Pro Ala Leu Thr Phe Asp Asp Cys 
            580                 585                 590         


Cys Cys Arg Gln Gly Arg Gly Trp Gly Ala Gln Cys Arg Pro Cys Pro 
        595                 600                 605             


Pro Arg Gly Ala Gly Ser His Cys Pro Thr Ser Gln Ser Glu Ser Asn 
    610                 615                 620                 


Ser Phe Trp Asp Thr Ser Pro Leu Leu Leu Gly Lys Pro Pro Arg Asp 
625                 630                 635                 640 


Glu Asp Ser Ser Glu Glu Asp Ser Asp Glu Cys Arg Cys Val Ser Gly 
                645                 650                 655     


Arg Cys Val Pro Arg Pro Gly Gly Ala Val Cys Glu Cys Pro Gly Gly 
            660                 665                 670         


Phe Gln Leu Asp Ala Ser Arg Ala Arg Cys Val Asp Ile Asp Glu Cys 
        675                 680                 685             


Arg Glu Leu Asn Gln Arg Gly Leu Leu Cys Lys Ser Glu Arg Cys Val 
    690                 695                 700                 


Asn Thr Ser Gly Ser Phe Arg Cys Val Cys Lys Ala Gly Phe Ala Arg 
705                 710                 715                 720 


Ser Arg Pro His Gly Ala Cys Val Pro Gln Arg Arg Arg 
                725                 730             


<210>  8116
<211>  1256
<212>  PRT
<213>  Homo Sapiens

<400>  8116

Met Pro Gly Pro Arg Gly Ala Ala Gly Gly Leu Ala Pro Glu Met Arg 
1               5                   10                  15      


Gly Ala Gly Ala Ala Gly Leu Leu Ala Leu Leu Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Gly Leu Gly Gly Arg Val Glu Gly Gly Pro Ala Gly Glu 
        35                  40                  45              


Arg Gly Ala Gly Gly Gly Gly Ala Leu Ala Arg Glu Arg Phe Lys Val 
    50                  55                  60                  


Val Phe Ala Pro Val Ile Cys Lys Arg Thr Cys Leu Lys Gly Gln Cys 
65                  70                  75                  80  


Arg Asp Ser Cys Gln Gln Gly Ser Asn Met Thr Leu Ile Gly Glu Asn 
                85                  90                  95      


Gly His Ser Thr Asp Thr Leu Thr Gly Ser Gly Phe Arg Val Val Val 
            100                 105                 110         


Cys Pro Leu Pro Cys Met Asn Gly Gly Gln Cys Ser Ser Arg Asn Gln 
        115                 120                 125             


Cys Leu Cys Pro Pro Asp Phe Thr Gly Arg Phe Cys Gln Val Pro Ala 
    130                 135                 140                 


Gly Gly Ala Gly Gly Gly Thr Gly Gly Ser Gly Pro Gly Leu Ser Arg 
145                 150                 155                 160 


Thr Gly Ala Leu Ser Thr Gly Ala Leu Pro Pro Leu Ala Pro Glu Gly 
                165                 170                 175     


Asp Ser Val Ala Ser Lys His Ala Ile Tyr Ala Val Gln Val Ile Ala 
            180                 185                 190         


Asp Pro Pro Gly Pro Gly Glu Gly Pro Pro Ala Gln His Ala Ala Phe 
        195                 200                 205             


Leu Val Pro Leu Gly Pro Gly Gln Ile Ser Ala Glu Val Gln Ala Pro 
    210                 215                 220                 


Pro Pro Val Val Asn Val Arg Val His His Pro Pro Glu Ala Ser Val 
225                 230                 235                 240 


Gln Val His Arg Ile Glu Ser Ser Asn Ala Glu Ser Ala Ala Pro Ser 
                245                 250                 255     


Gln His Leu Leu Pro His Pro Lys Pro Ser His Pro Arg Pro Pro Thr 
            260                 265                 270         


Gln Lys Pro Leu Gly Arg Cys Phe Gln Asp Thr Leu Pro Lys Gln Pro 
        275                 280                 285             


Cys Gly Ser Asn Pro Leu Pro Gly Leu Thr Lys Gln Glu Asp Cys Cys 
    290                 295                 300                 


Gly Ser Ile Gly Thr Ala Trp Gly Gln Ser Lys Cys His Lys Cys Pro 
305                 310                 315                 320 


Gln Leu Gln Tyr Thr Gly Val Gln Lys Pro Gly Pro Val Arg Gly Glu 
                325                 330                 335     


Val Gly Ala Asp Cys Pro Gln Gly Tyr Lys Arg Leu Asn Ser Thr His 
            340                 345                 350         


Cys Gln Asp Ile Asn Glu Cys Ala Met Pro Gly Val Cys Arg His Gly 
        355                 360                 365             


Asp Cys Leu Asn Asn Pro Gly Ser Tyr Arg Cys Val Cys Pro Pro Gly 
    370                 375                 380                 


His Ser Leu Gly Pro Ser Arg Thr Gln Cys Ile Ala Asp Lys Pro Glu 
385                 390                 395                 400 


Glu Lys Ser Leu Cys Phe Arg Leu Val Ser Pro Glu His Gln Cys Gln 
                405                 410                 415     


His Pro Leu Thr Thr Arg Leu Thr Arg Gln Leu Cys Cys Cys Ser Val 
            420                 425                 430         


Gly Lys Ala Trp Gly Ala Arg Cys Gln Arg Cys Pro Thr Asp Gly Thr 
        435                 440                 445             


Ala Ala Phe Lys Glu Ile Cys Pro Ala Gly Lys Gly Tyr His Ile Leu 
    450                 455                 460                 


Thr Ser His Gln Thr Leu Thr Ile Gln Gly Glu Ser Asp Phe Ser Leu 
465                 470                 475                 480 


Phe Leu His Pro Asp Gly Pro Pro Lys Pro Gln Gln Leu Pro Glu Ser 
                485                 490                 495     


Pro Ser Gln Ala Pro Pro Pro Glu Asp Thr Glu Glu Glu Arg Gly Val 
            500                 505                 510         


Thr Thr Asp Ser Pro Val Ser Glu Glu Arg Ser Val Gln Gln Ser His 
        515                 520                 525             


Pro Thr Ala Thr Thr Thr Pro Ala Arg Pro Tyr Pro Glu Leu Ile Ser 
    530                 535                 540                 


Arg Pro Ser Pro Pro Thr Met Arg Trp Phe Leu Pro Asp Leu Pro Pro 
545                 550                 555                 560 


Ser Arg Ser Ala Val Glu Ile Ala Pro Thr Gln Val Thr Glu Thr Asp 
                565                 570                 575     


Glu Cys Arg Leu Asn Gln Asn Ile Cys Gly His Gly Glu Cys Val Pro 
            580                 585                 590         


Gly Pro Pro Asp Tyr Ser Cys His Cys Asn Pro Gly Tyr Arg Ser His 
        595                 600                 605             


Pro Gln His Arg Tyr Cys Val Asp Val Asn Glu Cys Glu Ala Glu Pro 
    610                 615                 620                 


Cys Gly Pro Gly Arg Gly Ile Cys Met Asn Thr Gly Gly Ser Tyr Asn 
625                 630                 635                 640 


Cys His Cys Asn Arg Gly Tyr Arg Leu His Val Gly Ala Gly Gly Arg 
                645                 650                 655     


Ser Cys Val Asp Leu Asn Glu Cys Ala Lys Pro His Leu Cys Gly Asp 
            660                 665                 670         


Gly Gly Phe Cys Ile Asn Phe Pro Gly His Tyr Lys Cys Asn Cys Tyr 
        675                 680                 685             


Pro Gly Tyr Arg Leu Lys Ala Ser Arg Pro Pro Val Cys Glu Asp Ile 
    690                 695                 700                 


Asp Glu Cys Arg Asp Pro Ser Ser Cys Pro Asp Gly Lys Cys Glu Asn 
705                 710                 715                 720 


Lys Pro Gly Ser Phe Lys Cys Ile Ala Cys Gln Pro Gly Tyr Arg Ser 
                725                 730                 735     


Gln Gly Gly Gly Ala Cys Arg Asp Val Asn Glu Cys Ala Glu Gly Ser 
            740                 745                 750         


Pro Cys Ser Pro Gly Trp Cys Glu Asn Leu Pro Gly Ser Phe Arg Cys 
        755                 760                 765             


Thr Cys Ala Gln Gly Tyr Ala Pro Ala Pro Asp Gly Arg Ser Cys Leu 
    770                 775                 780                 


Asp Val Asp Glu Cys Glu Ala Gly Asp Val Cys Asp Asn Gly Ile Cys 
785                 790                 795                 800 


Ser Asn Thr Pro Gly Ser Phe Gln Cys Gln Cys Leu Ser Gly Tyr His 
                805                 810                 815     


Leu Ser Arg Asp Arg Ser His Cys Glu Asp Ile Asp Glu Cys Asp Phe 
            820                 825                 830         


Pro Ala Ala Cys Ile Gly Gly Asp Cys Ile Asn Thr Asn Gly Ser Tyr 
        835                 840                 845             


Arg Cys Leu Cys Pro Gln Gly His Arg Leu Val Gly Gly Arg Lys Cys 
    850                 855                 860                 


Gln Asp Ile Asp Glu Cys Ser Gln Asp Pro Ser Leu Cys Leu Pro His 
865                 870                 875                 880 


Gly Ala Cys Lys Asn Leu Gln Gly Ser Tyr Val Cys Val Cys Asp Glu 
                885                 890                 895     


Gly Phe Thr Pro Thr Gln Asp Gln His Gly Cys Glu Glu Val Glu Gln 
            900                 905                 910         


Pro His His Lys Lys Glu Cys Tyr Leu Asn Phe Asp Asp Thr Val Phe 
        915                 920                 925             


Cys Asp Ser Val Leu Ala Thr Asn Val Thr Gln Gln Glu Cys Cys Cys 
    930                 935                 940                 


Ser Leu Gly Ala Gly Trp Gly Asp His Cys Glu Ile Tyr Pro Cys Pro 
945                 950                 955                 960 


Val Tyr Ser Ser Ala Glu Phe His Ser Leu Cys Pro Asp Gly Lys Gly 
                965                 970                 975     


Tyr Thr Gln Asp Asn Asn Ile Val Asn Tyr Gly Ile Pro Ala His Arg 
            980                 985                 990         


Asp Ile Asp Glu Cys Met Leu Phe  Gly Ser Glu Ile Cys  Lys Glu Gly 
        995                 1000                 1005             


Lys Cys  Val Asn Thr Gln Pro  Gly Tyr Glu Cys Tyr  Cys Lys Gln 
    1010                 1015                 1020             


Gly Phe  Tyr Tyr Asp Gly Asn  Leu Leu Glu Cys Val  Asp Val Asp 
    1025                 1030                 1035             


Glu Cys  Leu Asp Glu Ser Asn  Cys Arg Asn Gly Val  Cys Glu Asn 
    1040                 1045                 1050             


Thr Arg  Gly Gly Tyr Arg Cys  Ala Cys Thr Pro Pro  Ala Glu Tyr 
    1055                 1060                 1065             


Ser Pro  Ala Gln Arg Gln Cys  Leu Ser Pro Glu Glu  Met Glu Arg 
    1070                 1075                 1080             


Ala Pro  Glu Arg Arg Asp Val  Cys Trp Ser Gln Arg  Gly Glu Asp 
    1085                 1090                 1095             


Gly Met  Cys Ala Gly Pro Leu  Ala Gly Pro Ala Leu  Thr Phe Asp 
    1100                 1105                 1110             


Asp Cys  Cys Cys Arg Gln Gly  Arg Gly Trp Gly Ala  Gln Cys Arg 
    1115                 1120                 1125             


Pro Cys  Pro Pro Arg Gly Ala  Gly Ser His Cys Pro  Thr Ser Gln 
    1130                 1135                 1140             


Ser Glu  Ser Asn Ser Phe Trp  Asp Thr Ser Pro Leu  Leu Leu Gly 
    1145                 1150                 1155             


Lys Pro  Pro Arg Asp Glu Asp  Ser Ser Glu Glu Asp  Ser Asp Glu 
    1160                 1165                 1170             


Cys Arg  Cys Val Ser Gly Arg  Cys Val Pro Arg Pro  Gly Gly Ala 
    1175                 1180                 1185             


Val Cys  Glu Cys Pro Gly Gly  Phe Gln Leu Asp Ala  Ser Arg Ala 
    1190                 1195                 1200             


Arg Cys  Val Asp Ile Asp Glu  Cys Arg Glu Leu Asn  Gln Arg Gly 
    1205                 1210                 1215             


Leu Leu  Cys Lys Ser Glu Arg  Cys Val Asn Thr Ser  Gly Ser Phe 
    1220                 1225                 1230             


Arg Cys  Val Cys Lys Ala Gly  Phe Ala Arg Ser Arg  Pro His Gly 
    1235                 1240                 1245             


Ala Cys  Val Pro Gln Arg Arg  Arg 
    1250                 1255     


<210>  8117
<211>  1303
<212>  PRT
<213>  Homo Sapiens

<400>  8117

Met Pro Gly Pro Arg Gly Ala Ala Gly Gly Leu Ala Pro Glu Met Arg 
1               5                   10                  15      


Gly Ala Gly Ala Ala Gly Leu Leu Ala Leu Leu Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Gly Leu Gly Gly Arg Val Glu Gly Gly Pro Ala Gly Glu 
        35                  40                  45              


Arg Gly Ala Gly Gly Gly Gly Ala Leu Ala Arg Glu Arg Phe Lys Val 
    50                  55                  60                  


Val Phe Ala Pro Val Ile Cys Lys Arg Thr Cys Leu Lys Gly Gln Cys 
65                  70                  75                  80  


Arg Asp Ser Cys Gln Gln Gly Ser Asn Met Thr Leu Ile Gly Glu Asn 
                85                  90                  95      


Gly His Ser Thr Asp Thr Leu Thr Gly Ser Gly Phe Arg Val Val Val 
            100                 105                 110         


Cys Pro Leu Pro Cys Met Asn Gly Gly Gln Cys Ser Ser Arg Asn Gln 
        115                 120                 125             


Cys Leu Cys Pro Pro Asp Phe Thr Gly Arg Phe Cys Gln Val Pro Ala 
    130                 135                 140                 


Gly Gly Ala Gly Gly Gly Thr Gly Gly Ser Gly Pro Gly Leu Ser Arg 
145                 150                 155                 160 


Thr Gly Ala Leu Ser Thr Gly Ala Leu Pro Pro Leu Ala Pro Glu Gly 
                165                 170                 175     


Asp Ser Val Ala Ser Lys His Ala Ile Tyr Ala Val Gln Val Ile Ala 
            180                 185                 190         


Asp Pro Pro Gly Pro Gly Glu Gly Pro Pro Ala Gln His Ala Ala Phe 
        195                 200                 205             


Leu Val Pro Leu Gly Pro Gly Gln Ile Ser Ala Glu Val Gln Ala Pro 
    210                 215                 220                 


Pro Pro Val Val Asn Val Arg Val His His Pro Pro Glu Ala Ser Val 
225                 230                 235                 240 


Gln Val His Arg Ile Glu Ser Ser Asn Ala Glu Ser Ala Ala Pro Ser 
                245                 250                 255     


Gln His Leu Leu Pro His Pro Lys Pro Ser His Pro Arg Pro Pro Thr 
            260                 265                 270         


Gln Lys Pro Leu Gly Arg Cys Phe Gln Asp Thr Leu Pro Lys Gln Pro 
        275                 280                 285             


Cys Gly Ser Asn Pro Leu Pro Gly Leu Thr Lys Gln Glu Asp Cys Cys 
    290                 295                 300                 


Gly Ser Ile Gly Thr Ala Trp Gly Gln Ser Lys Cys His Lys Cys Pro 
305                 310                 315                 320 


Gln Leu Gln Tyr Thr Gly Val Gln Lys Pro Gly Pro Val Arg Gly Glu 
                325                 330                 335     


Val Gly Ala Asp Cys Pro Gln Gly Tyr Lys Arg Leu Asn Ser Thr His 
            340                 345                 350         


Cys Gln Asp Ile Asn Glu Cys Ala Met Pro Gly Val Cys Arg His Gly 
        355                 360                 365             


Asp Cys Leu Asn Asn Pro Gly Ser Tyr Arg Cys Val Cys Pro Pro Gly 
    370                 375                 380                 


His Ser Leu Gly Pro Ser Arg Thr Gln Cys Ile Ala Asp Lys Pro Glu 
385                 390                 395                 400 


Glu Lys Ser Leu Cys Phe Arg Leu Val Ser Pro Glu His Gln Cys Gln 
                405                 410                 415     


His Pro Leu Thr Thr Arg Leu Thr Arg Gln Leu Cys Cys Cys Ser Val 
            420                 425                 430         


Gly Lys Ala Trp Gly Ala Arg Cys Gln Arg Cys Pro Thr Asp Gly Thr 
        435                 440                 445             


Ala Ala Phe Lys Glu Ile Cys Pro Ala Gly Lys Gly Tyr His Ile Leu 
    450                 455                 460                 


Thr Ser His Gln Thr Leu Thr Ile Gln Gly Glu Ser Asp Phe Ser Leu 
465                 470                 475                 480 


Phe Leu His Pro Asp Gly Pro Pro Lys Pro Gln Gln Leu Pro Glu Ser 
                485                 490                 495     


Pro Ser Gln Ala Pro Pro Pro Glu Asp Thr Glu Glu Glu Arg Gly Val 
            500                 505                 510         


Thr Thr Asp Ser Pro Val Ser Glu Glu Arg Ser Val Gln Gln Ser His 
        515                 520                 525             


Pro Thr Ala Thr Thr Thr Pro Ala Arg Pro Tyr Pro Glu Leu Ile Ser 
    530                 535                 540                 


Arg Pro Ser Pro Pro Thr Met Arg Trp Phe Leu Pro Asp Leu Pro Pro 
545                 550                 555                 560 


Ser Arg Ser Ala Val Glu Ile Ala Pro Thr Gln Val Thr Glu Thr Asp 
                565                 570                 575     


Glu Cys Arg Leu Asn Gln Asn Ile Cys Gly His Gly Glu Cys Val Pro 
            580                 585                 590         


Gly Pro Pro Asp Tyr Ser Cys His Cys Asn Pro Gly Tyr Arg Ser His 
        595                 600                 605             


Pro Gln His Arg Tyr Cys Val Asp Val Asn Glu Cys Glu Ala Glu Pro 
    610                 615                 620                 


Cys Gly Pro Gly Arg Gly Ile Cys Met Asn Thr Gly Gly Ser Tyr Asn 
625                 630                 635                 640 


Cys His Cys Asn Arg Gly Tyr Arg Leu His Val Gly Ala Gly Gly Arg 
                645                 650                 655     


Ser Cys Val Asp Leu Asn Glu Cys Ala Lys Pro His Leu Cys Gly Asp 
            660                 665                 670         


Gly Gly Phe Cys Ile Asn Phe Pro Gly His Tyr Lys Cys Asn Cys Tyr 
        675                 680                 685             


Pro Gly Tyr Arg Leu Lys Ala Ser Arg Pro Pro Val Cys Glu Asp Ile 
    690                 695                 700                 


Asp Glu Cys Arg Asp Pro Ser Ser Cys Pro Asp Gly Lys Cys Glu Asn 
705                 710                 715                 720 


Lys Pro Gly Ser Phe Lys Cys Ile Ala Cys Gln Pro Gly Tyr Arg Ser 
                725                 730                 735     


Gln Gly Gly Gly Ala Cys Arg Asp Val Asn Glu Cys Ala Glu Gly Ser 
            740                 745                 750         


Pro Cys Ser Pro Gly Trp Cys Glu Asn Leu Pro Gly Ser Phe Arg Cys 
        755                 760                 765             


Thr Cys Ala Gln Gly Tyr Ala Pro Ala Pro Asp Gly Arg Ser Cys Leu 
    770                 775                 780                 


Asp Val Asp Glu Cys Glu Ala Gly Asp Val Cys Asp Asn Gly Ile Cys 
785                 790                 795                 800 


Ser Asn Thr Pro Gly Ser Phe Gln Cys Gln Cys Leu Ser Gly Tyr His 
                805                 810                 815     


Leu Ser Arg Asp Arg Ser His Cys Glu Asp Ile Asp Glu Cys Asp Phe 
            820                 825                 830         


Pro Ala Ala Cys Ile Gly Gly Asp Cys Ile Asn Thr Asn Gly Ser Tyr 
        835                 840                 845             


Arg Cys Leu Cys Pro Gln Gly His Arg Leu Val Gly Gly Arg Lys Cys 
    850                 855                 860                 


Gln Asp Ile Asp Glu Cys Ser Gln Asp Pro Ser Leu Cys Leu Pro His 
865                 870                 875                 880 


Gly Ala Cys Lys Asn Leu Gln Gly Ser Tyr Val Cys Val Cys Asp Glu 
                885                 890                 895     


Gly Phe Thr Pro Thr Gln Asp Gln His Gly Cys Glu Glu Val Glu Gln 
            900                 905                 910         


Pro His His Lys Lys Glu Cys Tyr Leu Asn Phe Asp Asp Thr Val Phe 
        915                 920                 925             


Cys Asp Ser Val Leu Ala Thr Asn Val Thr Gln Gln Glu Cys Cys Cys 
    930                 935                 940                 


Ser Leu Gly Ala Gly Trp Gly Asp His Cys Glu Ile Tyr Pro Cys Pro 
945                 950                 955                 960 


Val Tyr Ser Ser Ala Glu Phe His Ser Leu Cys Pro Asp Gly Lys Gly 
                965                 970                 975     


Tyr Thr Gln Asp Asn Asn Ile Val Asn Tyr Gly Ile Pro Ala His Arg 
            980                 985                 990         


Asp Ile Asp Glu Cys Met Leu Phe  Gly Ser Glu Ile Cys  Lys Glu Gly 
        995                 1000                 1005             


Lys Cys  Val Asn Thr Gln Pro  Gly Tyr Glu Cys Tyr  Cys Lys Gln 
    1010                 1015                 1020             


Gly Phe  Tyr Tyr Asp Gly Asn  Leu Leu Glu Cys Val  Asp Val Asp 
    1025                 1030                 1035             


Glu Cys  Leu Asp Glu Ser Asn  Cys Arg Asn Gly Val  Cys Glu Asn 
    1040                 1045                 1050             


Thr Arg  Gly Gly Tyr Arg Cys  Ala Cys Thr Pro Pro  Ala Glu Tyr 
    1055                 1060                 1065             


Ser Pro  Ala Gln Arg Gln Cys  Leu Ser Pro Glu Glu  Met Asp Val 
    1070                 1075                 1080             


Asp Glu  Cys Gln Asp Pro Ala  Ala Cys Arg Pro Gly  Arg Cys Val 
    1085                 1090                 1095             


Asn Leu  Pro Gly Ser Tyr Arg  Cys Glu Cys Arg Pro  Pro Trp Val 
    1100                 1105                 1110             


Pro Gly  Pro Ser Gly Arg Asp  Cys Gln Leu Pro Glu  Ser Pro Ala 
    1115                 1120                 1125             


Glu Arg  Ala Pro Glu Arg Arg  Asp Val Cys Trp Ser  Gln Arg Gly 
    1130                 1135                 1140             


Glu Asp  Gly Met Cys Ala Gly  Pro Leu Ala Gly Pro  Ala Leu Thr 
    1145                 1150                 1155             


Phe Asp  Asp Cys Cys Cys Arg  Gln Gly Arg Gly Trp  Gly Ala Gln 
    1160                 1165                 1170             


Cys Arg  Pro Cys Pro Pro Arg  Gly Ala Gly Ser His  Cys Pro Thr 
    1175                 1180                 1185             


Ser Gln  Ser Glu Ser Asn Ser  Phe Trp Asp Thr Ser  Pro Leu Leu 
    1190                 1195                 1200             


Leu Gly  Lys Pro Pro Arg Asp  Glu Asp Ser Ser Glu  Glu Asp Ser 
    1205                 1210                 1215             


Asp Glu  Cys Arg Cys Val Ser  Gly Arg Cys Val Pro  Arg Pro Gly 
    1220                 1225                 1230             


Gly Ala  Val Cys Glu Cys Pro  Gly Gly Phe Gln Leu  Asp Ala Ser 
    1235                 1240                 1245             


Arg Ala  Arg Cys Val Asp Ile  Asp Glu Cys Arg Glu  Leu Asn Gln 
    1250                 1255                 1260             


Arg Gly  Leu Leu Cys Lys Ser  Glu Arg Cys Val Asn  Thr Ser Gly 
    1265                 1270                 1275             


Ser Phe  Arg Cys Val Cys Lys  Ala Gly Phe Ala Arg  Ser Arg Pro 
    1280                 1285                 1290             


His Gly  Ala Cys Val Pro Gln  Arg Arg Arg 
    1295                 1300             


<210>  8118
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  8118

Met Pro Gly Pro Arg Gly Ala Ala Gly Gly Leu Ala Pro Glu Met Arg 
1               5                   10                  15      


Gly Ala Gly Ala Ala Gly Leu Leu Ala Leu Leu Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Gly Leu Gly Gly Arg Val Glu Gly Gly Pro Ala Gly Glu 
        35                  40                  45              


Arg Gly Ala Gly Gly Gly Gly Ala Leu Ala Arg Glu Arg Phe Lys Val 
    50                  55                  60                  


Val Phe Ala Pro Val Ile Cys Lys Arg Thr Cys Leu Lys Gly Gln Cys 
65                  70                  75                  80  


Arg Asp Ser Cys Gln Gln Gly Ser Asn Met Thr Leu Ile Gly Glu Asn 
                85                  90                  95      


Gly His Ser Thr Asp Thr Leu Thr Gly Ser Gly Phe Arg Trp Cys Ala 
            100                 105                 110         


Leu Ser Pro Ala 
        115     


<210>  8119
<211>  1137
<212>  PRT
<213>  Homo Sapiens

<400>  8119

Met Thr Leu Ile Gly Glu Asn Gly His Ser Thr Asp Thr Leu Thr Gly 
1               5                   10                  15      


Ser Gly Phe Arg Val Val Val Cys Pro Leu Pro Cys Met Asn Gly Gly 
            20                  25                  30          


Gln Cys Ser Ser Arg Asn Gln Cys Leu Cys Pro Pro Asp Phe Thr Gly 
        35                  40                  45              


Arg Phe Cys Gln Val Pro Ala Gly Gly Ala Gly Gly Gly Thr Gly Gly 
    50                  55                  60                  


Ser Gly Pro Gly Leu Ser Arg Thr Gly Ala Leu Ser Thr Gly Ala Leu 
65                  70                  75                  80  


Pro Pro Leu Ala Pro Glu Gly Asp Ser Val Ala Ser Lys His Ala Ile 
                85                  90                  95      


Tyr Ala Val Gln Val Ile Ala Asp Pro Pro Gly Pro Gly Glu Gly Pro 
            100                 105                 110         


Pro Ala Gln His Ala Ala Phe Leu Val Pro Leu Gly Pro Gly Gln Ile 
        115                 120                 125             


Ser Ala Glu Val Gln Ala Pro Pro Pro Val Val Asn Val Arg Val His 
    130                 135                 140                 


His Pro Pro Glu Ala Ser Val Gln Val His Arg Ile Glu Ser Ser Asn 
145                 150                 155                 160 


Ala Glu Ser Ala Ala Pro Ser Gln His Leu Leu Pro His Pro Lys Pro 
                165                 170                 175     


Ser His Pro Arg Pro Pro Thr Gln Lys Pro Leu Gly Arg Cys Phe Gln 
            180                 185                 190         


Asp Thr Leu Pro Lys Gln Pro Cys Gly Ser Asn Pro Leu Pro Gly Leu 
        195                 200                 205             


Thr Lys Gln Glu Asp Cys Cys Gly Ser Ile Gly Thr Ala Trp Gly Gln 
    210                 215                 220                 


Ser Lys Cys His Lys Cys Pro Gln Leu Gln Tyr Thr Gly Val Gln Lys 
225                 230                 235                 240 


Pro Gly Pro Val Arg Gly Glu Val Gly Ala Asp Cys Pro Gln Gly Tyr 
                245                 250                 255     


Lys Arg Leu Asn Ser Thr His Cys Gln Asp Ile Asn Glu Cys Ala Met 
            260                 265                 270         


Pro Gly Val Cys Arg His Gly Asp Cys Leu Asn Asn Pro Gly Ser Tyr 
        275                 280                 285             


Arg Cys Val Cys Pro Pro Gly His Ser Leu Gly Pro Ser Arg Thr Gln 
    290                 295                 300                 


Cys Ile Ala Asp Lys Pro Glu Glu Lys Ser Leu Cys Phe Arg Leu Val 
305                 310                 315                 320 


Ser Pro Glu His Gln Cys Gln His Pro Leu Thr Thr Arg Leu Thr Arg 
                325                 330                 335     


Gln Leu Cys Cys Cys Ser Val Gly Lys Ala Trp Gly Ala Arg Cys Gln 
            340                 345                 350         


Arg Cys Pro Thr Asp Gly Thr Ala Ala Phe Lys Glu Ile Cys Pro Ala 
        355                 360                 365             


Gly Lys Gly Tyr His Ile Leu Thr Ser His Gln Thr Leu Thr Ile Gln 
    370                 375                 380                 


Gly Glu Ser Asp Phe Ser Leu Phe Leu His Pro Asp Gly Pro Pro Lys 
385                 390                 395                 400 


Pro Gln Gln Leu Pro Glu Ser Pro Ser Gln Ala Pro Pro Pro Glu Asp 
                405                 410                 415     


Thr Glu Glu Glu Arg Gly Val Thr Thr Asp Ser Pro Val Ser Glu Glu 
            420                 425                 430         


Arg Ser Val Gln Gln Ser His Pro Thr Ala Thr Thr Thr Pro Ala Arg 
        435                 440                 445             


Pro Tyr Pro Glu Leu Ile Ser Arg Pro Ser Pro Pro Thr Met Arg Trp 
    450                 455                 460                 


Phe Leu Pro Asp Leu Pro Pro Ser Arg Ser Ala Val Glu Ile Ala Pro 
465                 470                 475                 480 


Thr Gln Val Thr Glu Thr Asp Glu Cys Arg Leu Asn Gln Asn Ile Cys 
                485                 490                 495     


Gly His Gly Glu Cys Val Pro Gly Pro Pro Asp Tyr Ser Cys His Cys 
            500                 505                 510         


Asn Pro Gly Tyr Arg Ser His Pro Gln His Arg Tyr Cys Val Asp Val 
        515                 520                 525             


Asn Glu Cys Glu Ala Glu Pro Cys Gly Pro Gly Arg Gly Ile Cys Met 
    530                 535                 540                 


Asn Thr Gly Gly Ser Tyr Asn Cys His Cys Asn Arg Gly Tyr Arg Leu 
545                 550                 555                 560 


His Val Gly Ala Gly Gly Arg Ser Cys Val Asp Leu Asn Glu Cys Ala 
                565                 570                 575     


Lys Pro His Leu Cys Gly Asp Gly Gly Phe Cys Ile Asn Phe Pro Gly 
            580                 585                 590         


His Tyr Lys Cys Asn Cys Tyr Pro Gly Tyr Arg Leu Lys Ala Ser Arg 
        595                 600                 605             


Pro Pro Val Cys Glu Asp Ile Asp Glu Cys Arg Asp Pro Ser Ser Cys 
    610                 615                 620                 


Pro Asp Gly Lys Cys Glu Asn Lys Pro Gly Ser Phe Lys Cys Ile Ala 
625                 630                 635                 640 


Cys Gln Pro Gly Tyr Arg Ser Gln Gly Gly Gly Ala Cys Arg Asp Val 
                645                 650                 655     


Asn Glu Cys Ala Glu Gly Ser Pro Cys Ser Pro Gly Trp Cys Glu Asn 
            660                 665                 670         


Leu Pro Gly Ser Phe Arg Cys Thr Cys Ala Gln Gly Tyr Ala Pro Ala 
        675                 680                 685             


Pro Asp Gly Arg Ser Cys Leu Asp Val Asp Glu Cys Glu Ala Gly Asp 
    690                 695                 700                 


Val Cys Asp Asn Gly Ile Cys Ser Asn Thr Pro Gly Ser Phe Gln Cys 
705                 710                 715                 720 


Gln Cys Leu Ser Gly Tyr His Leu Ser Arg Asp Arg Ser His Cys Glu 
                725                 730                 735     


Asp Ile Asp Glu Cys Asp Phe Pro Ala Ala Cys Ile Gly Gly Asp Cys 
            740                 745                 750         


Ile Asn Thr Asn Gly Ser Tyr Arg Cys Leu Cys Pro Gln Gly His Arg 
        755                 760                 765             


Leu Val Gly Gly Arg Lys Cys Gln Asp Ile Asp Glu Cys Ser Gln Asp 
    770                 775                 780                 


Pro Ser Leu Cys Leu Pro His Gly Ala Cys Lys Asn Leu Gln Gly Ser 
785                 790                 795                 800 


Tyr Val Cys Val Cys Asp Glu Gly Phe Thr Pro Thr Gln Asp Gln His 
                805                 810                 815     


Gly Cys Glu Glu Val Glu Gln Pro His His Lys Lys Glu Cys Tyr Leu 
            820                 825                 830         


Asn Phe Asp Asp Thr Val Phe Cys Asp Ser Val Leu Ala Thr Asn Val 
        835                 840                 845             


Thr Gln Gln Glu Cys Cys Cys Ser Leu Gly Ala Gly Trp Gly Asp His 
    850                 855                 860                 


Cys Glu Ile Tyr Pro Cys Pro Val Tyr Ser Ser Ala Glu Phe His Ser 
865                 870                 875                 880 


Leu Cys Pro Asp Gly Lys Gly Tyr Thr Gln Asp Asn Asn Ile Val Asn 
                885                 890                 895     


Tyr Gly Ile Pro Ala His Arg Asp Ile Asp Glu Cys Met Leu Phe Gly 
            900                 905                 910         


Ser Glu Ile Cys Lys Glu Gly Lys Cys Val Asn Thr Gln Pro Gly Tyr 
        915                 920                 925             


Glu Cys Tyr Cys Lys Gln Gly Phe Tyr Tyr Asp Gly Asn Leu Leu Glu 
    930                 935                 940                 


Cys Val Asp Val Asp Glu Cys Leu Asp Glu Ser Asn Cys Arg Asn Gly 
945                 950                 955                 960 


Val Cys Glu Asn Thr Arg Gly Gly Tyr Arg Cys Ala Cys Thr Pro Pro 
                965                 970                 975     


Ala Glu Tyr Ser Pro Ala Gln Arg Gln Cys Leu Ser Pro Glu Glu Met 
            980                 985                 990         


Asp Val Asp Glu Cys Gln Asp Pro  Ala Ala Cys Arg Pro  Gly Arg Cys 
        995                 1000                 1005             


Val Asn  Leu Pro Gly Ser Tyr  Arg Cys Glu Cys Arg  Pro Pro Trp 
    1010                 1015                 1020             


Val Pro  Gly Pro Ser Gly Arg  Asp Cys Gln Leu Pro  Glu Ser Pro 
    1025                 1030                 1035             


Ala Glu  Arg Ala Pro Glu Arg  Arg Asp Val Cys Trp  Ser Gln Arg 
    1040                 1045                 1050             


Gly Glu  Asp Gly Met Cys Ala  Gly Pro Leu Ala Gly  Pro Ala Leu 
    1055                 1060                 1065             


Thr Phe  Asp Asp Cys Cys Cys  Arg Gln Gly Arg Gly  Trp Gly Ala 
    1070                 1075                 1080             


Gln Cys  Arg Pro Cys Pro Pro  Arg Gly Ala Gly Ser  His Cys Pro 
    1085                 1090                 1095             


Thr Ser  Gln Ser Glu Ser Asn  Ser Phe Trp Asp Thr  Ser Pro Leu 
    1100                 1105                 1110             


Leu Leu  Gly Lys Pro Pro Arg  Asp Glu Asp Ser Ser  Glu Glu Asp 
    1115                 1120                 1125             


Ser Asp  Glu Cys Arg Cys Val  Ser Gly 
    1130                 1135         


<210>  8120
<211>  907
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8120

Xaa Phe Ala Pro Val Ile Cys Lys Arg Thr Cys Leu Lys Gly Gln Cys 
1               5                   10                  15      


Arg Asp Ser Cys Gln Gln Gly Ser Asn Met Thr Leu Ile Gly Glu Asn 
            20                  25                  30          


Gly His Ser Thr Asp Thr Leu Thr Gly Ser Gly Phe Arg Val Ala Asp 
        35                  40                  45              


Lys Pro Glu Glu Lys Ser Leu Cys Phe Arg Leu Val Ser Pro Glu His 
    50                  55                  60                  


Gln Cys Gln His Pro Leu Thr Thr Arg Leu Thr Arg Gln Leu Cys Cys 
65                  70                  75                  80  


Cys Ser Val Gly Lys Ala Trp Gly Ala Arg Cys Gln Arg Cys Pro Thr 
                85                  90                  95      


Asp Gly Thr Ala Ala Phe Lys Glu Ile Cys Pro Ala Gly Lys Gly Tyr 
            100                 105                 110         


His Ile Leu Thr Ser His Gln Thr Leu Thr Ile Gln Gly Glu Ser Asp 
        115                 120                 125             


Phe Ser Leu Phe Leu His Pro Asp Gly Pro Pro Lys Pro Gln Gln Leu 
    130                 135                 140                 


Pro Glu Ser Pro Ser Gln Ala Pro Pro Pro Glu Asp Thr Glu Glu Glu 
145                 150                 155                 160 


Arg Gly Val Thr Thr Asp Ser Pro Val Ser Glu Glu Arg Ser Val Gln 
                165                 170                 175     


Gln Ser His Pro Thr Ala Thr Thr Thr Pro Ala Arg Pro Tyr Pro Glu 
            180                 185                 190         


Leu Ile Ser Arg Pro Ser Pro Pro Thr Met Arg Trp Phe Leu Pro Asp 
        195                 200                 205             


Leu Pro Pro Ser Arg Ser Ala Val Glu Ile Ala Pro Thr Gln Val Thr 
    210                 215                 220                 


Glu Thr Asp Glu Cys Arg Leu Asn Gln Asn Ile Cys Gly His Gly Glu 
225                 230                 235                 240 


Cys Val Pro Gly Pro Pro Asp Tyr Ser Cys His Cys Asn Pro Gly Tyr 
                245                 250                 255     


Arg Ser His Pro Gln His Arg Tyr Cys Val Asp Val Asn Glu Cys Glu 
            260                 265                 270         


Ala Glu Pro Cys Gly Pro Gly Arg Gly Ile Cys Met Asn Thr Gly Gly 
        275                 280                 285             


Ser Tyr Asn Cys His Cys Asn Arg Gly Tyr Arg Leu His Val Gly Ala 
    290                 295                 300                 


Gly Gly Arg Ser Cys Val Asp Leu Asn Glu Cys Ala Lys Pro His Leu 
305                 310                 315                 320 


Cys Gly Asp Gly Gly Phe Cys Ile Asn Phe Pro Gly His Tyr Lys Cys 
                325                 330                 335     


Asn Cys Tyr Pro Gly Tyr Arg Leu Lys Ala Ser Arg Pro Pro Val Cys 
            340                 345                 350         


Glu Asp Ile Asp Glu Cys Arg Asp Pro Ser Ser Cys Pro Asp Gly Lys 
        355                 360                 365             


Cys Glu Asn Lys Pro Gly Ser Phe Lys Cys Ile Ala Cys Gln Pro Gly 
    370                 375                 380                 


Tyr Arg Ser Gln Gly Gly Gly Ala Cys Arg Asp Val Asn Glu Cys Ala 
385                 390                 395                 400 


Glu Gly Ser Pro Cys Ser Pro Gly Trp Cys Glu Asn Leu Pro Gly Ser 
                405                 410                 415     


Phe Arg Cys Thr Cys Ala Gln Gly Tyr Ala Pro Ala Pro Asp Gly Arg 
            420                 425                 430         


Ser Cys Leu Asp Val Asp Glu Cys Glu Ala Gly Asp Val Cys Asp Asn 
        435                 440                 445             


Gly Ile Cys Ser Asn Thr Pro Gly Ser Phe Gln Cys Gln Cys Leu Ser 
    450                 455                 460                 


Gly Tyr His Leu Ser Arg Asp Arg Ser His Cys Glu Asp Ile Asp Glu 
465                 470                 475                 480 


Cys Asp Phe Pro Ala Ala Cys Ile Gly Gly Asp Cys Ile Asn Thr Asn 
                485                 490                 495     


Gly Ser Tyr Arg Cys Leu Cys Pro Gln Gly His Arg Leu Val Gly Gly 
            500                 505                 510         


Arg Lys Cys Gln Asp Ile Asp Glu Cys Ser Gln Asp Pro Ser Leu Cys 
        515                 520                 525             


Leu Pro His Gly Ala Cys Lys Asn Leu Gln Gly Ser Tyr Val Cys Val 
    530                 535                 540                 


Cys Asp Glu Gly Phe Thr Pro Thr Gln Asp Gln His Gly Cys Glu Glu 
545                 550                 555                 560 


Val Glu Gln Pro His His Lys Lys Glu Cys Tyr Leu Asn Phe Asp Asp 
                565                 570                 575     


Thr Val Phe Cys Asp Ser Val Leu Ala Thr Asn Val Thr Gln Gln Glu 
            580                 585                 590         


Cys Cys Cys Ser Leu Gly Ala Gly Trp Gly Asp His Cys Glu Ile Tyr 
        595                 600                 605             


Pro Cys Pro Val Tyr Ser Ser Ala Glu Phe His Ser Leu Cys Pro Asp 
    610                 615                 620                 


Gly Lys Gly Tyr Thr Gln Asp Asn Asn Ile Val Asn Tyr Gly Ile Pro 
625                 630                 635                 640 


Ala His Arg Asp Ile Asp Glu Cys Met Leu Phe Gly Ser Glu Ile Cys 
                645                 650                 655     


Lys Glu Gly Lys Cys Val Asn Thr Gln Pro Gly Tyr Glu Cys Tyr Cys 
            660                 665                 670         


Lys Gln Gly Phe Tyr Tyr Asp Gly Asn Leu Leu Glu Cys Val Asp Val 
        675                 680                 685             


Asp Glu Cys Leu Asp Glu Ser Asn Cys Arg Asn Gly Val Cys Glu Asn 
    690                 695                 700                 


Thr Arg Gly Gly Tyr Arg Cys Ala Cys Thr Pro Pro Ala Glu Tyr Ser 
705                 710                 715                 720 


Pro Ala Gln Arg Gln Cys Leu Ser Pro Glu Glu Met Glu Arg Ala Pro 
                725                 730                 735     


Glu Arg Arg Asp Val Cys Trp Ser Gln Arg Gly Glu Asp Gly Met Cys 
            740                 745                 750         


Ala Gly Pro Leu Ala Gly Pro Ala Leu Thr Phe Asp Asp Cys Cys Cys 
        755                 760                 765             


Arg Gln Gly Arg Gly Trp Gly Ala Gln Cys Arg Pro Cys Pro Pro Arg 
    770                 775                 780                 


Gly Ala Gly Ser His Cys Pro Thr Ser Gln Ser Glu Ser Asn Ser Phe 
785                 790                 795                 800 


Trp Asp Thr Ser Pro Leu Leu Leu Gly Lys Pro Pro Arg Asp Glu Asp 
                805                 810                 815     


Ser Ser Glu Glu Asp Ser Asp Glu Cys Arg Cys Val Ser Gly Arg Cys 
            820                 825                 830         


Val Pro Arg Pro Gly Gly Ala Val Cys Glu Cys Pro Gly Gly Phe Gln 
        835                 840                 845             


Leu Asp Ala Ser Arg Ala Arg Cys Val Asp Ile Asp Glu Cys Arg Glu 
    850                 855                 860                 


Leu Asn Gln Arg Gly Leu Leu Cys Lys Ser Glu Arg Cys Val Asn Thr 
865                 870                 875                 880 


Ser Gly Ser Phe Arg Cys Val Cys Lys Ala Gly Phe Ala Arg Ser Arg 
                885                 890                 895     


Pro His Gly Ala Cys Val Pro Gln Arg Arg Arg 
            900                 905         


<210>  8121
<211>  69
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8121

Xaa Phe Ala Pro Val Ile Cys Lys Arg Thr Cys Leu Lys Gly Gln Cys 
1               5                   10                  15      


Arg Asp Ser Cys Gln Gln Gly Ser Asn Met Thr Leu Ile Gly Glu Asn 
            20                  25                  30          


Gly His Ser Thr Asp Thr Leu Thr Gly Ser Gly Phe Arg Val Gly Pro 
        35                  40                  45              


Ala Pro Arg Gly Glu Cys Ala Arg Pro Ser Pro Ala Arg Gly Leu Ser 
    50                  55                  60                  


Pro Gly Ala Pro His 
65                  


<210>  8122
<211>  303
<212>  PRT
<213>  Homo Sapiens

<400>  8122

Glu Cys Leu Asn Thr Asp Gly Ser Phe Ala Cys Thr Cys Ala Pro Gly 
1               5                   10                  15      


Tyr Arg Pro Gly Pro Arg Gly Ala Ser Cys Leu Asp Val Asp Glu Cys 
            20                  25                  30          


Ser Glu Glu Asp Leu Cys Gln Ser Gly Ile Cys Thr Asn Thr Asp Gly 
        35                  40                  45              


Ser Phe Glu Cys Ile Cys Pro Pro Gly His Arg Ala Gly Pro Asp Leu 
    50                  55                  60                  


Ala Ser Cys Leu Asp Val Asp Glu Cys Arg Glu Arg Gly Pro Ala Leu 
65                  70                  75                  80  


Cys Gly Ser Gln Arg Cys Glu Asn Ser Pro Gly Ser Tyr Arg Cys Val 
                85                  90                  95      


Arg Asp Cys Asp Pro Gly Tyr His Ala Gly Pro Glu Gly Thr Cys Asp 
            100                 105                 110         


Asp Val Asn Glu Cys Glu Thr Leu Gln Gly Val Cys Gly Ala Ala Leu 
        115                 120                 125             


Cys Glu Asn Val Glu Gly Ser Phe Leu Cys Val Cys Pro Asn Ser Pro 
    130                 135                 140                 


Glu Glu Phe Asp Pro Met Thr Gly Arg Cys Val Pro Pro Arg Thr Ser 
145                 150                 155                 160 


Ala Asp Val Asp Glu Cys Gln Leu Phe Arg Asp Gln Val Cys Lys Ser 
                165                 170                 175     


Gly Val Cys Val Asn Thr Ala Pro Gly Tyr Ser Cys Tyr Cys Ser Asn 
            180                 185                 190         


Gly Tyr Tyr Tyr His Thr Gln Arg Leu Glu Cys Ile Asp Asn Asp Glu 
        195                 200                 205             


Cys Ala Asp Glu Glu Pro Ala Cys Glu Gly Gly Arg Cys Val Asn Thr 
    210                 215                 220                 


Val Gly Ser Tyr His Cys Thr Cys Glu Pro Pro Leu Val Leu Asp Gly 
225                 230                 235                 240 


Ser Gln Arg Arg Cys Val Ser Asn Glu Ser Gln Ser Leu Asp Asp Asn 
                245                 250                 255     


Leu Gly Val Cys Trp Gln Glu Val Gly Ala Asp Leu Val Cys Ser His 
            260                 265                 270         


Pro Arg Leu Asp Arg Gln Ala Thr Tyr Thr Glu Cys Cys Cys Leu Tyr 
        275                 280                 285             


Gly Glu Ala Trp Gly Met Asp Cys Ala Leu Cys Pro Ala Gln Asp 
    290                 295                 300             


<210>  8123
<211>  1557
<212>  PRT
<213>  Homo Sapiens

<400>  8123

Met Ala Gly Gly Val Arg Leu Leu Trp Val Ser Leu Leu Val Leu Leu 
1               5                   10                  15      


Ala Gln Leu Gly Pro Gln Pro Gly Leu Gly Arg Leu Gly Glu Arg Leu 
            20                  25                  30          


Arg Val Arg Phe Thr Pro Val Val Cys Gly Leu Arg Cys Val His Gly 
        35                  40                  45              


Pro Thr Gly Ser Arg Cys Thr Pro Thr Cys Ala Pro Arg Asn Ala Thr 
    50                  55                  60                  


Ser Val Asp Ser Gly Ala Pro Gly Gly Ala Ala Pro Gly Gly Pro Gly 
65                  70                  75                  80  


Phe Arg Ala Phe Leu Cys Pro Leu Ile Cys His Asn Gly Gly Val Cys 
                85                  90                  95      


Val Lys Pro Asp Arg Cys Leu Cys Pro Pro Asp Phe Ala Gly Lys Phe 
            100                 105                 110         


Cys Gln Leu His Ser Ser Gly Ala Arg Pro Pro Ala Pro Ala Val Pro 
        115                 120                 125             


Gly Leu Thr Arg Ser Val Tyr Thr Met Pro Leu Ala Asn His Arg Asp 
    130                 135                 140                 


Asp Glu His Gly Val Ala Ser Met Val Ser Val His Val Glu His Pro 
145                 150                 155                 160 


Gln Glu Ala Ser Val Val Val His Gln Val Glu Arg Val Ser Gly Pro 
                165                 170                 175     


Trp Glu Glu Ala Asp Ala Glu Ala Val Ala Arg Ala Glu Ala Ala Ala 
            180                 185                 190         


Arg Ala Glu Ala Ala Ala Pro Tyr Thr Val Leu Ala Gln Ser Ala Pro 
        195                 200                 205             


Arg Glu Asp Gly Tyr Ser Asp Ala Ser Gly Phe Gly Tyr Cys Phe Arg 
    210                 215                 220                 


Glu Leu Arg Gly Gly Glu Cys Ala Ser Pro Leu Pro Gly Leu Arg Thr 
225                 230                 235                 240 


Gln Glu Val Cys Cys Arg Gly Ala Gly Leu Ala Trp Gly Val His Asp 
                245                 250                 255     


Cys Gln Leu Cys Ser Glu Arg Leu Gly Asn Ser Glu Arg Val Ser Ala 
            260                 265                 270         


Pro Asp Gly Pro Cys Pro Thr Gly Phe Glu Arg Val Asn Gly Ser Cys 
        275                 280                 285             


Glu Asp Val Asp Glu Cys Ala Thr Gly Gly Arg Cys Gln His Gly Glu 
    290                 295                 300                 


Cys Ala Asn Thr Arg Gly Gly Tyr Thr Cys Val Cys Pro Asp Gly Phe 
305                 310                 315                 320 


Leu Leu Asp Ser Ser Arg Ser Ser Cys Ile Ser Gln His Val Ile Ser 
                325                 330                 335     


Glu Ala Lys Gly Pro Cys Phe Arg Val Leu Arg Asp Gly Gly Cys Ser 
            340                 345                 350         


Leu Pro Ile Leu Arg Asn Ile Thr Lys Gln Ile Cys Cys Cys Ser Arg 
        355                 360                 365             


Val Gly Lys Ala Trp Gly Arg Gly Cys Gln Leu Cys Pro Pro Phe Gly 
    370                 375                 380                 


Ser Glu Gly Phe Arg Glu Ile Cys Pro Ala Gly Pro Gly Tyr His Tyr 
385                 390                 395                 400 


Ser Ala Ser Asp Leu Arg Tyr Asn Thr Arg Pro Leu Gly Gln Glu Pro 
                405                 410                 415     


Pro Arg Val Ser Leu Ser Gln Pro Arg Thr Leu Pro Ala Thr Ser Arg 
            420                 425                 430         


Pro Ser Ala Gly Phe Leu Pro Thr His Arg Leu Glu Pro Arg Pro Glu 
        435                 440                 445             


Pro Arg Pro Asp Pro Arg Pro Gly Pro Glu Leu Pro Leu Pro Ser Ile 
    450                 455                 460                 


Pro Ala Trp Thr Gly Pro Glu Ile Pro Glu Ser Gly Pro Ser Ser Gly 
465                 470                 475                 480 


Met Cys Gln Arg Asn Pro Gln Val Cys Gly Pro Gly Arg Cys Ile Ser 
                485                 490                 495     


Arg Pro Ser Gly Tyr Thr Cys Ala Cys Asp Ser Gly Phe Arg Leu Ser 
            500                 505                 510         


Pro Gln Gly Thr Arg Cys Ile Asp Val Asp Glu Cys Arg Arg Val Pro 
        515                 520                 525             


Pro Pro Cys Ala Pro Gly Arg Cys Glu Asn Ser Pro Gly Ser Phe Arg 
    530                 535                 540                 


Cys Val Cys Gly Pro Gly Phe Arg Ala Gly Pro Arg Ala Ala Glu Cys 
545                 550                 555                 560 


Leu Asp Val Asp Glu Cys His Arg Val Pro Pro Pro Cys Asp Leu Gly 
                565                 570                 575     


Arg Cys Glu Asn Thr Pro Gly Ser Phe Leu Cys Val Cys Pro Ala Gly 
            580                 585                 590         


Tyr Gln Ala Ala Pro His Gly Ala Ser Cys Gln Asp Val Asp Glu Cys 
        595                 600                 605             


Thr Gln Ser Pro Gly Leu Cys Gly Arg Gly Ala Cys Lys Asn Leu Pro 
    610                 615                 620                 


Gly Ser Phe Arg Cys Val Cys Pro Ala Gly Phe Arg Gly Ser Ala Cys 
625                 630                 635                 640 


Glu Glu Asp Val Asp Glu Cys Ala Gln Glu Pro Pro Pro Cys Gly Pro 
                645                 650                 655     


Gly Arg Cys Asp Asn Thr Ala Gly Ser Phe His Cys Ala Cys Pro Ala 
            660                 665                 670         


Gly Phe Arg Ser Arg Gly Pro Gly Ala Pro Cys Gln Asp Val Asp Glu 
        675                 680                 685             


Cys Ala Arg Ser Pro Pro Pro Cys Thr Tyr Gly Arg Cys Glu Asn Thr 
    690                 695                 700                 


Glu Gly Ser Phe Gln Cys Val Cys Pro Met Gly Phe Gln Pro Asn Thr 
705                 710                 715                 720 


Ala Gly Ser Glu Cys Glu Asp Val Asp Glu Cys Glu Asn His Leu Ala 
                725                 730                 735     


Cys Pro Gly Gln Glu Cys Val Asn Ser Pro Gly Ser Phe Gln Cys Arg 
            740                 745                 750         


Thr Cys Pro Ser Gly His His Leu His Arg Gly Arg Cys Thr Asp Val 
        755                 760                 765             


Asp Glu Cys Ser Ser Gly Ala Pro Pro Cys Gly Pro His Gly His Cys 
    770                 775                 780                 


Thr Asn Thr Glu Gly Ser Phe Arg Cys Ser Cys Ala Pro Gly Tyr Arg 
785                 790                 795                 800 


Ala Pro Ser Gly Arg Pro Gly Pro Cys Ala Asp Val Asn Glu Cys Leu 
                805                 810                 815     


Glu Gly Asp Phe Cys Phe Pro His Gly Glu Cys Leu Asn Thr Asp Gly 
            820                 825                 830         


Ser Phe Ala Cys Thr Cys Ala Pro Gly Tyr Arg Pro Gly Pro Arg Gly 
        835                 840                 845             


Ala Ser Cys Leu Asp Val Asp Glu Cys Ser Glu Glu Asp Leu Cys Gln 
    850                 855                 860                 


Ser Gly Ile Cys Thr Asn Thr Asp Gly Ser Phe Glu Cys Ile Cys Pro 
865                 870                 875                 880 


Pro Gly His Arg Ala Gly Pro Asp Leu Ala Ser Cys Leu Asp Val Asp 
                885                 890                 895     


Glu Cys Arg Glu Arg Gly Pro Ala Leu Cys Gly Ser Gln Arg Cys Glu 
            900                 905                 910         


Asn Ser Pro Gly Ser Tyr Arg Cys Val Arg Asp Cys Asp Pro Gly Tyr 
        915                 920                 925             


His Ala Gly Pro Glu Gly Thr Cys Asp Asp Val Asp Glu Cys Gln Glu 
    930                 935                 940                 


Tyr Gly Pro Glu Ile Cys Gly Ala Gln Arg Cys Glu Asn Thr Pro Gly 
945                 950                 955                 960 


Ser Tyr Arg Cys Thr Pro Ala Cys Asp Pro Gly Tyr Gln Pro Thr Pro 
                965                 970                 975     


Gly Gly Gly Cys Gln Asp Val Asp Glu Cys Arg Asn Arg Ser Phe Cys 
            980                 985                 990         


Gly Ala His Ala Val Cys Gln Asn  Leu Pro Gly Ser Phe  Gln Cys Leu 
        995                 1000                 1005             


Cys Asp  Gln Gly Tyr Glu Gly  Ala Arg Asp Gly Arg  His Cys Val 
    1010                 1015                 1020             


Asp Val  Asn Glu Cys Glu Thr  Leu Gln Gly Val Cys  Gly Ala Ala 
    1025                 1030                 1035             


Leu Cys  Glu Asn Val Glu Gly  Ser Phe Leu Cys Val  Cys Pro Asn 
    1040                 1045                 1050             


Ser Pro  Glu Glu Phe Asp Pro  Met Thr Gly Arg Cys  Val Pro Pro 
    1055                 1060                 1065             


Arg Thr  Ser Ala Gly Thr Phe  Pro Gly Ser Gln Pro  Gln Ala Pro 
    1070                 1075                 1080             


Ala Ser  Pro Val Leu Pro Ala  Arg Pro Pro Pro Pro  Pro Leu Pro 
    1085                 1090                 1095             


Arg Arg  Pro Ser Thr Pro Arg  Gln Gly Pro Val Gly  Ser Gly Arg 
    1100                 1105                 1110             


Arg Glu  Cys Tyr Phe Asp Thr  Ala Ala Pro Asp Ala  Cys Asp Asn 
    1115                 1120                 1125             


Ile Leu  Ala Arg Asn Val Thr  Trp Gln Glu Cys Cys  Cys Thr Val 
    1130                 1135                 1140             


Gly Glu  Gly Trp Gly Ser Gly  Cys Arg Ile Gln Gln  Cys Pro Gly 
    1145                 1150                 1155             


Thr Glu  Thr Ala Glu Tyr Gln  Ser Leu Cys Pro His  Gly Arg Gly 
    1160                 1165                 1170             


Tyr Leu  Ala Pro Ser Gly Asp  Leu Ser Leu Arg Arg  Asp Val Asp 
    1175                 1180                 1185             


Glu Cys  Gln Leu Phe Arg Asp  Gln Val Cys Lys Ser  Gly Val Cys 
    1190                 1195                 1200             


Val Asn  Thr Ala Pro Gly Tyr  Ser Cys Tyr Cys Ser  Asn Gly Tyr 
    1205                 1210                 1215             


Tyr Tyr  His Thr Gln Arg Leu  Glu Cys Ile Asp Asn  Asp Glu Cys 
    1220                 1225                 1230             


Ala Asp  Glu Glu Pro Ala Cys  Glu Gly Gly Arg Cys  Val Asn Thr 
    1235                 1240                 1245             


Val Gly  Ser Tyr His Cys Thr  Cys Glu Pro Pro Leu  Val Leu Asp 
    1250                 1255                 1260             


Gly Ser  Gln Arg Arg Cys Val  Ser Asn Glu Ser Gln  Ser Leu Asp 
    1265                 1270                 1275             


Asp Asn  Leu Gly Val Cys Trp  Gln Glu Val Gly Ala  Asp Leu Val 
    1280                 1285                 1290             


Cys Ser  His Pro Arg Leu Asp  Arg Gln Ala Thr Tyr  Thr Glu Cys 
    1295                 1300                 1305             


Cys Cys  Leu Tyr Gly Glu Ala  Trp Gly Met Asp Cys  Ala Leu Cys 
    1310                 1315                 1320             


Pro Ala  Gln Asp Ser Asp Asp  Phe Glu Ala Leu Cys  Asn Val Leu 
    1325                 1330                 1335             


Arg Pro  Pro Ala Tyr Ser Pro  Pro Arg Pro Gly Gly  Phe Gly Leu 
    1340                 1345                 1350             


Pro Tyr  Glu Tyr Gly Pro Asp  Leu Gly Pro Pro Tyr  Gln Gly Leu 
    1355                 1360                 1365             


Pro Tyr  Gly Pro Glu Leu Tyr  Pro Pro Pro Ala Leu  Pro Tyr Asp 
    1370                 1375                 1380             


Pro Tyr  Pro Pro Pro Pro Gly  Pro Phe Ala Arg Arg  Glu Ala Pro 
    1385                 1390                 1395             


Tyr Gly  Ala Pro Arg Phe Asp  Met Pro Asp Phe Glu  Asp Asp Gly 
    1400                 1405                 1410             


Gly Pro  Tyr Gly Glu Ser Glu  Ala Pro Ala Pro Pro  Gly Pro Gly 
    1415                 1420                 1425             


Thr Arg  Trp Pro Tyr Arg Ser  Arg Asp Thr Arg Arg  Ser Phe Pro 
    1430                 1435                 1440             


Glu Pro  Glu Glu Pro Pro Glu  Gly Gly Ser Tyr Ala  Gly Ser Leu 
    1445                 1450                 1455             


Ala Glu  Pro Tyr Glu Glu Leu  Glu Ala Glu Glu Cys  Gly Ile Leu 
    1460                 1465                 1470             


Asp Gly  Cys Thr Asn Gly Arg  Cys Val Arg Val Pro  Glu Gly Phe 
    1475                 1480                 1485             


Thr Cys  Arg Cys Phe Asp Gly  Tyr Arg Leu Asp Met  Thr Arg Met 
    1490                 1495                 1500             


Ala Cys  Val Asp Ile Asn Glu  Cys Asp Glu Ala Glu  Ala Ala Ser 
    1505                 1510                 1515             


Pro Leu  Cys Val Asn Ala Arg  Cys Leu Asn Thr Asp  Gly Ser Phe 
    1520                 1525                 1530             


Arg Cys  Ile Cys Arg Pro Gly  Phe Ala Pro Thr His  Gln Pro His 
    1535                 1540                 1545             


His Cys  Ala Pro Ala Arg Pro  Arg Ala 
    1550                 1555         


<210>  8124
<211>  44
<212>  PRT
<213>  Homo Sapiens

<400>  8124

Met Gly Asp Val Lys Ala Leu Leu Phe Val Ala Ala Ala Arg Ala Arg 
1               5                   10                  15      


Arg Leu Gly Gly Ala Ala Ala Ser Glu Pro Ser Ala Gly Ser Glu Ala 
            20                  25                  30          


Ala Ser Pro Lys Ser Val Gln Ala Pro Ser Gly Ala 
        35                  40                  


<210>  8125
<211>  1587
<212>  PRT
<213>  Homo Sapiens

<400>  8125

Met Gly Asp Val Lys Ala Leu Leu Phe Val Ala Ala Ala Arg Ala Arg 
1               5                   10                  15      


Arg Leu Gly Gly Ala Ala Ala Ser Glu Ser Leu Ala Val Ser Glu Ala 
            20                  25                  30          


Phe Cys Arg Val Arg Ser Cys Gln Pro Lys Lys Cys Ala Gly Pro Gln 
        35                  40                  45              


Arg Cys Leu Asn Pro Val Pro Ala Val Pro Ser Pro Ser Pro Ser Val 
    50                  55                  60                  


Arg Lys Arg Gln Val Ser Leu Asn Trp Gln Pro Leu Thr Leu Gln Glu 
65                  70                  75                  80  


Ala Arg Ala Leu Leu Lys Arg Arg Arg Pro Arg Gly Pro Gly Gly Arg 
                85                  90                  95      


Gly Leu Leu Arg Arg Arg Pro Pro Gln Arg Ala Pro Ala Gly Lys Ala 
            100                 105                 110         


Pro Val Leu Cys Pro Leu Ile Cys His Asn Gly Gly Val Cys Val Lys 
        115                 120                 125             


Pro Asp Arg Cys Leu Cys Pro Pro Asp Phe Ala Gly Lys Phe Cys Gln 
    130                 135                 140                 


Leu His Ser Ser Gly Ala Arg Pro Pro Ala Pro Ala Val Pro Gly Leu 
145                 150                 155                 160 


Thr Arg Ser Val Tyr Thr Met Pro Leu Ala Asn His Arg Asp Asp Glu 
                165                 170                 175     


His Gly Val Ala Ser Met Val Ser Val His Val Glu His Pro Gln Glu 
            180                 185                 190         


Ala Ser Val Val Val His Gln Val Glu Arg Val Ser Gly Pro Trp Glu 
        195                 200                 205             


Glu Ala Asp Ala Glu Ala Val Ala Arg Ala Glu Ala Ala Ala Arg Ala 
    210                 215                 220                 


Glu Ala Ala Ala Pro Tyr Thr Val Leu Ala Gln Ser Ala Pro Arg Glu 
225                 230                 235                 240 


Asp Gly Tyr Ser Asp Ala Ser Gly Phe Gly Tyr Cys Phe Arg Glu Leu 
                245                 250                 255     


Arg Gly Gly Glu Cys Ala Ser Pro Leu Pro Gly Leu Arg Thr Gln Glu 
            260                 265                 270         


Val Cys Cys Arg Gly Ala Gly Leu Ala Trp Gly Val His Asp Cys Gln 
        275                 280                 285             


Leu Cys Ser Glu Arg Leu Gly Asn Ser Glu Arg Val Ser Ala Pro Asp 
    290                 295                 300                 


Gly Pro Cys Pro Thr Gly Phe Glu Arg Val Asn Gly Ser Cys Glu Asp 
305                 310                 315                 320 


Val Asp Glu Cys Ala Thr Gly Gly Arg Cys Gln His Gly Glu Cys Ala 
                325                 330                 335     


Asn Thr Arg Gly Gly Tyr Thr Cys Val Cys Pro Asp Gly Phe Leu Leu 
            340                 345                 350         


Asp Ser Ser Arg Ser Ser Cys Ile Ser Gln His Val Ile Ser Glu Ala 
        355                 360                 365             


Lys Gly Pro Cys Phe Arg Val Leu Arg Asp Gly Gly Cys Ser Leu Pro 
    370                 375                 380                 


Ile Leu Arg Asn Ile Thr Lys Gln Ile Cys Cys Cys Ser Arg Val Gly 
385                 390                 395                 400 


Lys Ala Trp Gly Arg Gly Cys Gln Leu Cys Pro Pro Phe Gly Ser Glu 
                405                 410                 415     


Gly Phe Arg Glu Ile Cys Pro Ala Gly Pro Gly Tyr His Tyr Ser Ala 
            420                 425                 430         


Ser Asp Leu Arg Tyr Asn Thr Arg Pro Leu Gly Gln Glu Pro Pro Arg 
        435                 440                 445             


Val Ser Leu Ser Gln Pro Arg Thr Leu Pro Ala Thr Ser Arg Pro Ser 
    450                 455                 460                 


Ala Gly Phe Leu Pro Thr His Arg Leu Glu Pro Arg Pro Glu Pro Arg 
465                 470                 475                 480 


Pro Asp Pro Arg Pro Gly Pro Glu Leu Pro Leu Pro Ser Ile Pro Ala 
                485                 490                 495     


Trp Thr Gly Pro Glu Ile Pro Glu Ser Gly Pro Ser Ser Gly Met Cys 
            500                 505                 510         


Gln Arg Asn Pro Gln Val Cys Gly Pro Gly Arg Cys Ile Ser Arg Pro 
        515                 520                 525             


Ser Gly Tyr Thr Cys Ala Cys Asp Ser Gly Phe Arg Leu Ser Pro Gln 
    530                 535                 540                 


Gly Thr Arg Cys Ile Asp Val Asp Glu Cys Arg Arg Val Pro Pro Pro 
545                 550                 555                 560 


Cys Ala Pro Gly Arg Cys Glu Asn Ser Pro Gly Ser Phe Arg Cys Val 
                565                 570                 575     


Cys Gly Pro Gly Phe Arg Ala Gly Pro Arg Ala Ala Glu Cys Leu Asp 
            580                 585                 590         


Val Asp Glu Cys His Arg Val Pro Pro Pro Cys Asp Leu Gly Arg Cys 
        595                 600                 605             


Glu Asn Thr Pro Gly Ser Phe Leu Cys Val Cys Pro Ala Gly Tyr Gln 
    610                 615                 620                 


Ala Ala Pro His Gly Ala Ser Cys Gln Asp Val Asp Glu Cys Thr Gln 
625                 630                 635                 640 


Ser Pro Gly Leu Cys Gly Arg Gly Ala Cys Lys Asn Leu Pro Gly Ser 
                645                 650                 655     


Phe Arg Cys Val Cys Pro Ala Gly Phe Arg Gly Ser Ala Cys Glu Glu 
            660                 665                 670         


Asp Val Asp Glu Cys Ala Gln Glu Pro Pro Pro Cys Gly Pro Gly Arg 
        675                 680                 685             


Cys Asp Asn Thr Ala Gly Ser Phe His Cys Ala Cys Pro Ala Gly Phe 
    690                 695                 700                 


Arg Ser Arg Gly Pro Gly Ala Pro Cys Gln Asp Val Asp Glu Cys Ala 
705                 710                 715                 720 


Arg Ser Pro Pro Pro Cys Thr Tyr Gly Arg Cys Glu Asn Thr Glu Gly 
                725                 730                 735     


Ser Phe Gln Cys Val Cys Pro Met Gly Phe Gln Pro Asn Thr Ala Gly 
            740                 745                 750         


Ser Glu Cys Glu Asp Val Asp Glu Cys Glu Asn His Leu Ala Cys Pro 
        755                 760                 765             


Gly Gln Glu Cys Val Asn Ser Pro Gly Ser Phe Gln Cys Arg Thr Cys 
    770                 775                 780                 


Pro Ser Gly His His Leu His Arg Gly Arg Cys Thr Asp Val Asp Glu 
785                 790                 795                 800 


Cys Ser Ser Gly Ala Pro Pro Cys Gly Pro His Gly His Cys Thr Asn 
                805                 810                 815     


Thr Glu Gly Ser Phe Arg Cys Ser Cys Ala Pro Gly Tyr Arg Ala Pro 
            820                 825                 830         


Ser Gly Arg Pro Gly Pro Cys Ala Asp Val Asn Glu Cys Leu Glu Gly 
        835                 840                 845             


Asp Phe Cys Phe Pro His Gly Glu Cys Leu Asn Thr Asp Gly Ser Phe 
    850                 855                 860                 


Ala Cys Thr Cys Ala Pro Gly Tyr Arg Pro Gly Pro Arg Gly Ala Ser 
865                 870                 875                 880 


Cys Leu Asp Val Asp Glu Cys Ser Glu Glu Asp Leu Cys Gln Ser Gly 
                885                 890                 895     


Ile Cys Thr Asn Thr Asp Gly Ser Phe Glu Cys Ile Cys Pro Pro Gly 
            900                 905                 910         


His Arg Ala Gly Pro Asp Leu Ala Ser Cys Leu Asp Val Asp Glu Cys 
        915                 920                 925             


Arg Glu Arg Gly Pro Ala Leu Cys Gly Ser Gln Arg Cys Glu Asn Ser 
    930                 935                 940                 


Pro Gly Ser Tyr Arg Cys Val Arg Asp Cys Asp Pro Gly Tyr His Ala 
945                 950                 955                 960 


Gly Pro Glu Gly Thr Cys Asp Asp Val Asp Glu Cys Gln Glu Tyr Gly 
                965                 970                 975     


Pro Glu Ile Cys Gly Ala Gln Arg Cys Glu Asn Thr Pro Gly Ser Tyr 
            980                 985                 990         


Arg Cys Thr Pro Ala Cys Asp Pro  Gly Tyr Gln Pro Thr  Pro Gly Gly 
        995                 1000                 1005             


Gly Cys  Gln Asp Val Asp Glu  Cys Arg Asn Arg Ser  Phe Cys Gly 
    1010                 1015                 1020             


Ala His  Ala Val Cys Gln Asn  Leu Pro Gly Ser Phe  Gln Cys Leu 
    1025                 1030                 1035             


Cys Asp  Gln Gly Tyr Glu Gly  Ala Arg Asp Gly Arg  His Cys Val 
    1040                 1045                 1050             


Asp Val  Asn Glu Cys Glu Thr  Leu Gln Gly Val Cys  Gly Ala Ala 
    1055                 1060                 1065             


Leu Cys  Glu Asn Val Glu Gly  Ser Phe Leu Cys Val  Cys Pro Asn 
    1070                 1075                 1080             


Ser Pro  Glu Glu Phe Asp Pro  Met Thr Gly Arg Cys  Val Pro Pro 
    1085                 1090                 1095             


Arg Thr  Ser Ala Gly Thr Phe  Pro Gly Ser Gln Pro  Gln Ala Pro 
    1100                 1105                 1110             


Ala Ser  Pro Val Leu Pro Ala  Arg Pro Pro Pro Pro  Pro Leu Pro 
    1115                 1120                 1125             


Arg Arg  Pro Ser Thr Pro Arg  Gln Gly Pro Val Gly  Ser Gly Arg 
    1130                 1135                 1140             


Arg Glu  Cys Tyr Phe Asp Thr  Ala Ala Pro Asp Ala  Cys Asp Asn 
    1145                 1150                 1155             


Ile Leu  Ala Arg Asn Val Thr  Trp Gln Glu Cys Cys  Cys Thr Val 
    1160                 1165                 1170             


Gly Glu  Gly Trp Gly Ser Gly  Cys Arg Ile Gln Gln  Cys Pro Gly 
    1175                 1180                 1185             


Thr Glu  Thr Ala Glu Tyr Gln  Ser Leu Cys Pro His  Gly Arg Gly 
    1190                 1195                 1200             


Tyr Leu  Ala Pro Ser Gly Asp  Leu Ser Leu Arg Arg  Asp Val Asp 
    1205                 1210                 1215             


Glu Cys  Gln Leu Phe Arg Asp  Gln Val Cys Lys Ser  Gly Val Cys 
    1220                 1225                 1230             


Val Asn  Thr Ala Pro Gly Tyr  Ser Cys Tyr Cys Ser  Asn Gly Tyr 
    1235                 1240                 1245             


Tyr Tyr  His Thr Gln Arg Leu  Glu Cys Ile Asp Asn  Asp Glu Cys 
    1250                 1255                 1260             


Ala Asp  Glu Glu Pro Ala Cys  Glu Gly Gly Arg Cys  Val Asn Thr 
    1265                 1270                 1275             


Val Gly  Ser Tyr His Cys Thr  Cys Glu Pro Pro Leu  Val Leu Asp 
    1280                 1285                 1290             


Gly Ser  Gln Arg Arg Cys Val  Ser Asn Glu Ser Gln  Ser Leu Asp 
    1295                 1300                 1305             


Asp Asn  Leu Gly Val Cys Trp  Gln Glu Val Gly Ala  Asp Leu Val 
    1310                 1315                 1320             


Cys Ser  His Pro Arg Leu Asp  Arg Gln Ala Thr Tyr  Thr Glu Cys 
    1325                 1330                 1335             


Cys Cys  Leu Tyr Gly Glu Ala  Trp Gly Met Asp Cys  Ala Leu Cys 
    1340                 1345                 1350             


Pro Ala  Gln Asp Ser Asp Asp  Phe Glu Ala Leu Cys  Asn Val Leu 
    1355                 1360                 1365             


Arg Pro  Pro Ala Tyr Ser Pro  Pro Arg Pro Gly Gly  Phe Gly Leu 
    1370                 1375                 1380             


Pro Tyr  Glu Tyr Gly Pro Asp  Leu Gly Pro Pro Tyr  Gln Gly Leu 
    1385                 1390                 1395             


Pro Tyr  Gly Pro Glu Leu Tyr  Pro Pro Pro Ala Leu  Pro Tyr Asp 
    1400                 1405                 1410             


Pro Tyr  Pro Pro Pro Pro Gly  Pro Phe Ala Arg Arg  Glu Ala Pro 
    1415                 1420                 1425             


Tyr Gly  Ala Pro Arg Phe Asp  Met Pro Asp Phe Glu  Asp Asp Gly 
    1430                 1435                 1440             


Gly Pro  Tyr Gly Glu Ser Glu  Ala Pro Ala Pro Pro  Gly Pro Gly 
    1445                 1450                 1455             


Thr Arg  Trp Pro Tyr Arg Ser  Arg Asp Thr Arg Arg  Ser Phe Pro 
    1460                 1465                 1470             


Glu Pro  Glu Glu Pro Pro Glu  Gly Gly Ser Tyr Ala  Gly Ser Leu 
    1475                 1480                 1485             


Ala Glu  Pro Tyr Glu Glu Leu  Glu Ala Glu Glu Cys  Gly Ile Leu 
    1490                 1495                 1500             


Asp Gly  Cys Thr Asn Gly Arg  Cys Val Arg Val Pro  Glu Gly Phe 
    1505                 1510                 1515             


Thr Cys  Arg Cys Phe Asp Gly  Tyr Arg Leu Asp Met  Thr Arg Met 
    1520                 1525                 1530             


Ala Cys  Val Asp Ile Asn Glu  Cys Asp Glu Ala Glu  Ala Ala Ser 
    1535                 1540                 1545             


Pro Leu  Cys Val Asn Ala Arg  Cys Leu Asn Thr Asp  Gly Ser Phe 
    1550                 1555                 1560             


Arg Cys  Ile Cys Arg Pro Gly  Phe Ala Pro Thr His  Gln Pro His 
    1565                 1570                 1575             


His Cys  Ala Pro Ala Arg Pro  Arg Ala 
    1580                 1585         


<210>  8126
<211>  44
<212>  PRT
<213>  Homo Sapiens

<400>  8126

Met Leu Gln Pro Gln Ala Leu Leu Phe Val Ala Ala Ala Arg Ala Arg 
1               5                   10                  15      


Arg Leu Gly Gly Ala Ala Ala Ser Glu Pro Ser Ala Gly Ser Glu Ala 
            20                  25                  30          


Ala Ser Pro Lys Ser Val Gln Ala Pro Ser Gly Ala 
        35                  40                  


<210>  8127
<211>  1624
<212>  PRT
<213>  Homo Sapiens

<400>  8127

Met Pro Arg Pro Gly Thr Ser Gly Arg Arg Pro Leu Leu Leu Val Leu 
1               5                   10                  15      


Leu Leu Pro Leu Phe Ala Ala Ala Thr Ser Ala Ala Ser Pro Ser Pro 
            20                  25                  30          


Ser Pro Ser Gln Val Val Glu Val Pro Gly Val Pro Ser Arg Pro Ala 
        35                  40                  45              


Ser Val Ala Val Cys Arg Cys Cys Pro Gly Gln Thr Ser Arg Arg Ser 
    50                  55                  60                  


Arg Cys Ile Arg Ala Phe Cys Arg Val Arg Ser Cys Gln Pro Lys Lys 
65                  70                  75                  80  


Cys Ala Gly Pro Gln Arg Cys Leu Asn Pro Val Pro Ala Val Pro Ser 
                85                  90                  95      


Pro Ser Pro Ser Val Arg Lys Arg Gln Val Ser Leu Asn Trp Gln Pro 
            100                 105                 110         


Leu Thr Leu Gln Glu Ala Arg Ala Leu Leu Lys Arg Arg Arg Pro Arg 
        115                 120                 125             


Gly Pro Gly Gly Arg Gly Leu Leu Arg Arg Arg Pro Pro Gln Arg Ala 
    130                 135                 140                 


Pro Ala Gly Lys Ala Pro Val Leu Cys Pro Leu Ile Cys His Asn Gly 
145                 150                 155                 160 


Gly Val Cys Val Lys Pro Asp Arg Cys Leu Cys Pro Pro Asp Phe Ala 
                165                 170                 175     


Gly Lys Phe Cys Gln Leu His Ser Ser Gly Ala Arg Pro Pro Ala Pro 
            180                 185                 190         


Ala Val Pro Gly Leu Thr Arg Ser Val Tyr Thr Met Pro Leu Ala Asn 
        195                 200                 205             


His Arg Asp Asp Glu His Gly Val Ala Ser Met Val Ser Val His Val 
    210                 215                 220                 


Glu His Pro Gln Glu Ala Ser Val Val Val His Gln Val Glu Arg Val 
225                 230                 235                 240 


Ser Gly Pro Trp Glu Glu Ala Asp Ala Glu Ala Val Ala Arg Ala Glu 
                245                 250                 255     


Ala Ala Ala Arg Ala Glu Ala Ala Ala Pro Tyr Thr Val Leu Ala Gln 
            260                 265                 270         


Ser Ala Pro Arg Glu Asp Gly Tyr Ser Asp Ala Ser Gly Phe Gly Tyr 
        275                 280                 285             


Cys Phe Arg Glu Leu Arg Gly Gly Glu Cys Ala Ser Pro Leu Pro Gly 
    290                 295                 300                 


Leu Arg Thr Gln Glu Val Cys Cys Arg Gly Ala Gly Leu Ala Trp Gly 
305                 310                 315                 320 


Val His Asp Cys Gln Leu Cys Ser Glu Arg Leu Gly Asn Ser Glu Arg 
                325                 330                 335     


Val Ser Ala Pro Asp Gly Pro Cys Pro Thr Gly Phe Glu Arg Val Asn 
            340                 345                 350         


Gly Ser Cys Glu Asp Val Asp Glu Cys Ala Thr Gly Gly Arg Cys Gln 
        355                 360                 365             


His Gly Glu Cys Ala Asn Thr Arg Gly Gly Tyr Thr Cys Val Cys Pro 
    370                 375                 380                 


Asp Gly Phe Leu Leu Asp Ser Ser Arg Ser Ser Cys Ile Ser Gln His 
385                 390                 395                 400 


Val Ile Ser Glu Ala Lys Gly Pro Cys Phe Arg Val Leu Arg Asp Gly 
                405                 410                 415     


Gly Cys Ser Leu Pro Ile Leu Arg Asn Ile Thr Lys Gln Ile Cys Cys 
            420                 425                 430         


Cys Ser Arg Val Gly Lys Ala Trp Gly Arg Gly Cys Gln Leu Cys Pro 
        435                 440                 445             


Pro Phe Gly Ser Glu Gly Phe Arg Glu Ile Cys Pro Ala Gly Pro Gly 
    450                 455                 460                 


Tyr His Tyr Ser Ala Ser Asp Leu Arg Tyr Asn Thr Arg Pro Leu Gly 
465                 470                 475                 480 


Gln Glu Pro Pro Arg Val Ser Leu Ser Gln Pro Arg Thr Leu Pro Ala 
                485                 490                 495     


Thr Ser Arg Pro Ser Ala Gly Phe Leu Pro Thr His Arg Leu Glu Pro 
            500                 505                 510         


Arg Pro Glu Pro Arg Pro Asp Pro Arg Pro Gly Pro Glu Leu Pro Leu 
        515                 520                 525             


Pro Ser Ile Pro Ala Trp Thr Gly Pro Glu Ile Pro Glu Ser Gly Pro 
    530                 535                 540                 


Ser Ser Gly Met Cys Gln Arg Asn Pro Gln Val Cys Gly Pro Gly Arg 
545                 550                 555                 560 


Cys Ile Ser Arg Pro Ser Gly Tyr Thr Cys Ala Cys Asp Ser Gly Phe 
                565                 570                 575     


Arg Leu Ser Pro Gln Gly Thr Arg Cys Ile Asp Val Asp Glu Cys Arg 
            580                 585                 590         


Arg Val Pro Pro Pro Cys Ala Pro Gly Arg Cys Glu Asn Ser Pro Gly 
        595                 600                 605             


Ser Phe Arg Cys Val Cys Gly Pro Gly Phe Arg Ala Gly Pro Arg Ala 
    610                 615                 620                 


Ala Glu Cys Leu Asp Val Asp Glu Cys His Arg Val Pro Pro Pro Cys 
625                 630                 635                 640 


Asp Leu Gly Arg Cys Glu Asn Thr Pro Gly Ser Phe Leu Cys Val Cys 
                645                 650                 655     


Pro Ala Gly Tyr Gln Ala Ala Pro His Gly Ala Ser Cys Gln Asp Val 
            660                 665                 670         


Asp Glu Cys Thr Gln Ser Pro Gly Leu Cys Gly Arg Gly Ala Cys Lys 
        675                 680                 685             


Asn Leu Pro Gly Ser Phe Arg Cys Val Cys Pro Ala Gly Phe Arg Gly 
    690                 695                 700                 


Ser Ala Cys Glu Glu Asp Val Asp Glu Cys Ala Gln Glu Pro Pro Pro 
705                 710                 715                 720 


Cys Gly Pro Gly Arg Cys Asp Asn Thr Ala Gly Ser Phe His Cys Ala 
                725                 730                 735     


Cys Pro Ala Gly Phe Arg Ser Arg Gly Pro Gly Ala Pro Cys Gln Asp 
            740                 745                 750         


Val Asp Glu Cys Ala Arg Ser Pro Pro Pro Cys Thr Tyr Gly Arg Cys 
        755                 760                 765             


Glu Asn Thr Glu Gly Ser Phe Gln Cys Val Cys Pro Met Gly Phe Gln 
    770                 775                 780                 


Pro Asn Thr Ala Gly Ser Glu Cys Glu Asp Val Asp Glu Cys Glu Asn 
785                 790                 795                 800 


His Leu Ala Cys Pro Gly Gln Glu Cys Val Asn Ser Pro Gly Ser Phe 
                805                 810                 815     


Gln Cys Arg Thr Cys Pro Ser Gly His His Leu His Arg Gly Arg Cys 
            820                 825                 830         


Thr Asp Val Asp Glu Cys Ser Ser Gly Ala Pro Pro Cys Gly Pro His 
        835                 840                 845             


Gly His Cys Thr Asn Thr Glu Gly Ser Phe Arg Cys Ser Cys Ala Pro 
    850                 855                 860                 


Gly Tyr Arg Ala Pro Ser Gly Arg Pro Gly Pro Cys Ala Asp Val Asn 
865                 870                 875                 880 


Glu Cys Leu Glu Gly Asp Phe Cys Phe Pro His Gly Glu Cys Leu Asn 
                885                 890                 895     


Thr Asp Gly Ser Phe Ala Cys Thr Cys Ala Pro Gly Tyr Arg Pro Gly 
            900                 905                 910         


Pro Arg Gly Ala Ser Cys Leu Asp Val Asp Glu Cys Ser Glu Glu Asp 
        915                 920                 925             


Leu Cys Gln Ser Gly Ile Cys Thr Asn Thr Asp Gly Ser Phe Glu Cys 
    930                 935                 940                 


Ile Cys Pro Pro Gly His Arg Ala Gly Pro Asp Leu Ala Ser Cys Leu 
945                 950                 955                 960 


Asp Val Asp Glu Cys Arg Glu Arg Gly Pro Ala Leu Cys Gly Ser Gln 
                965                 970                 975     


Arg Cys Glu Asn Ser Pro Gly Ser Tyr Arg Cys Val Arg Asp Cys Asp 
            980                 985                 990         


Pro Gly Tyr His Ala Gly Pro Glu  Gly Thr Cys Asp Asp  Val Asp Glu 
        995                 1000                 1005             


Cys Gln  Glu Tyr Gly Pro Glu  Ile Cys Gly Ala Gln  Arg Cys Glu 
    1010                 1015                 1020             


Asn Thr  Pro Gly Ser Tyr Arg  Cys Thr Pro Ala Cys  Asp Pro Gly 
    1025                 1030                 1035             


Tyr Gln  Pro Thr Pro Gly Gly  Gly Cys Gln Asp Val  Asp Glu Cys 
    1040                 1045                 1050             


Arg Asn  Arg Ser Phe Cys Gly  Ala His Ala Val Cys  Gln Asn Leu 
    1055                 1060                 1065             


Pro Gly  Ser Phe Gln Cys Leu  Cys Asp Gln Gly Tyr  Glu Gly Ala 
    1070                 1075                 1080             


Arg Asp  Gly Arg His Cys Val  Asp Val Asn Glu Cys  Glu Thr Leu 
    1085                 1090                 1095             


Gln Gly  Val Cys Gly Ala Ala  Leu Cys Glu Asn Val  Glu Gly Ser 
    1100                 1105                 1110             


Phe Leu  Cys Val Cys Pro Asn  Ser Pro Glu Glu Phe  Asp Pro Met 
    1115                 1120                 1125             


Thr Gly  Arg Cys Val Pro Pro  Arg Thr Ser Ala Gly  Thr Phe Pro 
    1130                 1135                 1140             


Gly Ser  Gln Pro Gln Ala Pro  Ala Ser Pro Val Leu  Pro Ala Arg 
    1145                 1150                 1155             


Pro Pro  Pro Pro Pro Leu Pro  Arg Arg Pro Ser Thr  Pro Arg Gln 
    1160                 1165                 1170             


Gly Pro  Val Gly Ser Gly Arg  Arg Glu Cys Tyr Phe  Asp Thr Ala 
    1175                 1180                 1185             


Ala Pro  Asp Ala Cys Asp Asn  Ile Leu Ala Arg Asn  Val Thr Trp 
    1190                 1195                 1200             


Gln Glu  Cys Cys Cys Thr Val  Gly Glu Gly Trp Gly  Ser Gly Cys 
    1205                 1210                 1215             


Arg Ile  Gln Gln Cys Pro Gly  Thr Glu Thr Ala Glu  Tyr Gln Ser 
    1220                 1225                 1230             


Leu Cys  Pro His Gly Arg Gly  Tyr Leu Ala Pro Ser  Gly Asp Leu 
    1235                 1240                 1245             


Ser Leu  Arg Arg Asp Val Asp  Glu Cys Gln Leu Phe  Arg Asp Gln 
    1250                 1255                 1260             


Val Cys  Lys Ser Gly Val Cys  Val Asn Thr Ala Pro  Gly Tyr Ser 
    1265                 1270                 1275             


Cys Tyr  Cys Ser Asn Gly Tyr  Tyr Tyr His Thr Gln  Arg Leu Glu 
    1280                 1285                 1290             


Cys Ile  Asp Asn Asp Glu Cys  Ala Asp Glu Glu Pro  Ala Cys Glu 
    1295                 1300                 1305             


Gly Gly  Arg Cys Val Asn Thr  Val Gly Ser Tyr His  Cys Thr Cys 
    1310                 1315                 1320             


Glu Pro  Pro Leu Val Leu Asp  Gly Ser Gln Arg Arg  Cys Val Ser 
    1325                 1330                 1335             


Asn Glu  Ser Gln Ser Leu Asp  Asp Asn Leu Gly Val  Cys Trp Gln 
    1340                 1345                 1350             


Glu Val  Gly Ala Asp Leu Val  Cys Ser His Pro Arg  Leu Asp Arg 
    1355                 1360                 1365             


Gln Ala  Thr Tyr Thr Glu Cys  Cys Cys Leu Tyr Gly  Glu Ala Trp 
    1370                 1375                 1380             


Gly Met  Asp Cys Ala Leu Cys  Pro Ala Gln Asp Ser  Asp Asp Phe 
    1385                 1390                 1395             


Glu Ala  Leu Cys Asn Val Leu  Arg Pro Pro Ala Tyr  Ser Pro Pro 
    1400                 1405                 1410             


Arg Pro  Gly Gly Phe Gly Leu  Pro Tyr Glu Tyr Gly  Pro Asp Leu 
    1415                 1420                 1425             


Gly Pro  Pro Tyr Gln Gly Leu  Pro Tyr Gly Pro Glu  Leu Tyr Pro 
    1430                 1435                 1440             


Pro Pro  Ala Leu Pro Tyr Asp  Pro Tyr Pro Pro Pro  Pro Gly Pro 
    1445                 1450                 1455             


Phe Ala  Arg Arg Glu Ala Pro  Tyr Gly Ala Pro Arg  Phe Asp Met 
    1460                 1465                 1470             


Pro Asp  Phe Glu Asp Asp Gly  Gly Pro Tyr Gly Glu  Ser Glu Ala 
    1475                 1480                 1485             


Pro Ala  Pro Pro Gly Pro Gly  Thr Arg Trp Pro Tyr  Arg Ser Arg 
    1490                 1495                 1500             


Asp Thr  Arg Arg Ser Phe Pro  Glu Pro Glu Glu Pro  Pro Glu Gly 
    1505                 1510                 1515             


Gly Ser  Tyr Ala Gly Ser Leu  Ala Glu Pro Tyr Glu  Glu Leu Glu 
    1520                 1525                 1530             


Ala Glu  Glu Cys Gly Ile Leu  Asp Gly Cys Thr Asn  Gly Arg Cys 
    1535                 1540                 1545             


Val Arg  Val Pro Glu Gly Phe  Thr Cys Arg Cys Phe  Asp Gly Tyr 
    1550                 1555                 1560             


Arg Leu  Asp Met Thr Arg Met  Ala Cys Val Asp Ile  Asn Glu Cys 
    1565                 1570                 1575             


Asp Glu  Ala Glu Ala Ala Ser  Pro Leu Cys Val Asn  Ala Arg Cys 
    1580                 1585                 1590             


Leu Asn  Thr Asp Gly Ser Phe  Arg Cys Ile Cys Arg  Pro Gly Phe 
    1595                 1600                 1605             


Ala Pro  Thr His Gln Pro His  His Cys Ala Pro Ala  Arg Pro Arg 
    1610                 1615                 1620             


Ala 
    


<210>  8128
<211>  70
<212>  PRT
<213>  Homo Sapiens

<400>  8128

Met Ser Ala Arg Thr Ala Pro Phe Ser Trp Ser Gly Gly Lys Leu Arg 
1               5                   10                  15      


Pro Lys Asp Gln Glu Thr Leu Ala Ser Gly His Thr Ser Trp Lys Ala 
            20                  25                  30          


Leu Leu Phe Val Ala Ala Ala Arg Ala Arg Arg Leu Gly Gly Ala Ala 
        35                  40                  45              


Ala Ser Glu Pro Ser Ala Gly Ser Glu Ala Ala Ser Pro Lys Ser Val 
    50                  55                  60                  


Gln Ala Pro Ser Gly Ala 
65                  70  


<210>  8129
<211>  145
<212>  PRT
<213>  Homo Sapiens

<400>  8129

Pro Pro Gly Pro Gly Thr Arg Trp Pro Tyr Arg Ser Arg Asp Thr Arg 
1               5                   10                  15      


Arg Ser Phe Pro Glu Pro Glu Glu Pro Pro Glu Gly Gly Ser Tyr Ala 
            20                  25                  30          


Gly Ser Leu Ala Glu Pro Tyr Glu Glu Leu Glu Ala Glu Glu Cys Gly 
        35                  40                  45              


Ile Leu Asp Gly Cys Thr Asn Gly Arg Cys Val Arg Val Pro Glu Gly 
    50                  55                  60                  


Phe Thr Cys Arg Cys Phe Asp Gly Tyr Arg Leu Asp Met Thr Arg Met 
65                  70                  75                  80  


Ala Cys Val Ala Phe Ser Ser Asp Arg Cys Leu Pro Ser Ala Asp Ile 
                85                  90                  95      


Asn Glu Cys Asp Glu Ala Glu Ala Ala Ser Pro Leu Cys Val Asn Ala 
            100                 105                 110         


Arg Cys Leu Asn Thr Asp Gly Ser Phe Arg Cys Ile Cys Arg Pro Gly 
        115                 120                 125             


Phe Ala Pro Thr His Gln Pro His His Cys Ala Pro Ala Arg Pro Arg 
    130                 135                 140                 


Ala 
145 


<210>  8130
<211>  252
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8130

Xaa Phe Arg Cys Ser Cys Ala Pro Gly Tyr Arg Ala Pro Ser Gly Arg 
1               5                   10                  15      


Pro Gly Pro Cys Ala Asp Val Asn Glu Cys Leu Glu Gly Asp Phe Cys 
            20                  25                  30          


Phe Pro His Gly Glu Cys Leu Asn Thr Asp Gly Ser Phe Ala Cys Thr 
        35                  40                  45              


Cys Ala Pro Gly Tyr Arg Pro Gly Pro Arg Gly Ala Ser Cys Leu Asp 
    50                  55                  60                  


Val Asp Glu Cys Ser Glu Glu Asp Leu Cys Gln Ser Gly Ile Cys Thr 
65                  70                  75                  80  


Asn Thr Asp Gly Ser Phe Glu Cys Ile Cys Pro Pro Gly His Arg Ala 
                85                  90                  95      


Gly Pro Asp Leu Ala Ser Cys Leu Asp Val Asp Glu Cys Arg Glu Arg 
            100                 105                 110         


Gly Pro Ala Leu Cys Gly Ser Gln Arg Cys Glu Asn Ser Pro Gly Ser 
        115                 120                 125             


Tyr Arg Cys Val Arg Asp Cys Asp Pro Gly Tyr His Ala Gly Pro Glu 
    130                 135                 140                 


Gly Thr Cys Asp Asp Val Asp Glu Cys Arg Asn Arg Ser Phe Cys Gly 
145                 150                 155                 160 


Ala His Ala Val Cys Gln Asn Leu Pro Gly Ser Phe Gln Cys Leu Cys 
                165                 170                 175     


Asp Gln Gly Tyr Glu Gly Ala Arg Asp Gly Arg His Cys Val Asp Val 
            180                 185                 190         


Asn Glu Cys Glu Thr Leu Gln Gly Val Cys Gly Ala Ala Leu Cys Glu 
        195                 200                 205             


Asn Val Glu Gly Ser Phe Leu Cys Val Cys Pro Asn Ser Pro Glu Glu 
    210                 215                 220                 


Phe Asp Pro Met Thr Gly Arg Cys Val Pro Pro Arg Thr Ser Ala Gly 
225                 230                 235                 240 


Thr Phe Pro Gly Ser Gln Pro Gln Ala Pro Ala Ser 
                245                 250         


<210>  8131
<211>  182
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8131

Xaa Gly Pro Glu Ile Cys Gly Ala Gln Arg Cys Glu Asn Thr Pro Gly 
1               5                   10                  15      


Ser Tyr Arg Cys Thr Pro Ala Cys Asp Pro Gly Tyr Gln Pro Thr Pro 
            20                  25                  30          


Gly Gly Gly Cys Gln Asp Val Asp Glu Cys Arg Asn Arg Ser Phe Cys 
        35                  40                  45              


Gly Ala His Ala Val Cys Gln Asn Leu Pro Gly Ser Phe Gln Cys Leu 
    50                  55                  60                  


Cys Asp Gln Gly Tyr Glu Gly Ala Arg Asp Gly Arg His Cys Val Asp 
65                  70                  75                  80  


Val Asn Glu Cys Glu Thr Leu Gln Gly Val Cys Gly Ala Ala Leu Cys 
                85                  90                  95      


Glu Asn Val Glu Gly Ser Phe Leu Cys Val Cys Pro Asn Ser Pro Glu 
            100                 105                 110         


Glu Phe Asp Pro Met Thr Gly Arg Cys Val Pro Pro Arg Thr Ser Ala 
        115                 120                 125             


Asp Val Asp Glu Cys Gln Leu Phe Arg Asp Gln Val Cys Lys Ser Gly 
    130                 135                 140                 


Val Cys Val Asn Thr Ala Pro Gly Tyr Ser Cys Tyr Cys Ser Asn Gly 
145                 150                 155                 160 


Tyr Tyr Tyr His Thr Gln Arg Leu Glu Cys Ile Asp Asn Asp Glu Cys 
                165                 170                 175     


Ala Asp Glu Glu Pro Ala 
            180         


<210>  8132
<211>  224
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8132

Xaa Asn Thr Asp Gly Ser Phe Ala Cys Thr Cys Ala Pro Gly Tyr Arg 
1               5                   10                  15      


Pro Gly Pro Arg Gly Ala Ser Cys Leu Asp Val Asp Glu Cys Ser Glu 
            20                  25                  30          


Glu Asp Leu Cys Gln Ser Gly Ile Cys Thr Asn Thr Asp Gly Ser Phe 
        35                  40                  45              


Glu Cys Ile Cys Pro Pro Gly His Arg Ala Gly Pro Asp Leu Ala Ser 
    50                  55                  60                  


Cys Leu Asp Val Asp Glu Cys Arg Glu Arg Gly Pro Ala Leu Cys Gly 
65                  70                  75                  80  


Ser Gln Arg Cys Glu Asn Ser Pro Gly Ser Tyr Arg Cys Val Arg Asp 
                85                  90                  95      


Cys Asp Pro Gly Tyr His Ala Gly Pro Glu Gly Thr Cys Asp Asp Val 
            100                 105                 110         


Asp Glu Cys Gln Glu Tyr Gly Pro Glu Ile Cys Gly Ala Gln Arg Cys 
        115                 120                 125             


Glu Asn Thr Pro Gly Ser Tyr Arg Cys Thr Pro Ala Cys Asp Pro Gly 
    130                 135                 140                 


Tyr Gln Pro Thr Pro Gly Gly Gly Cys Gln Asp Val Asn Glu Cys Glu 
145                 150                 155                 160 


Thr Leu Gln Gly Val Cys Gly Ala Ala Leu Cys Glu Asn Val Glu Gly 
                165                 170                 175     


Ser Phe Leu Cys Val Cys Pro Asn Ser Pro Glu Glu Phe Asp Pro Met 
            180                 185                 190         


Thr Gly Arg Cys Val Pro Pro Arg Thr Ser Ala Gly Thr Phe Pro Gly 
        195                 200                 205             


Ser Gln Pro Gln Ala Pro Ala Ser Pro Val Leu Pro Ala Arg Pro Pro 
    210                 215                 220                 


<210>  8133
<211>  674
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8133

Xaa Asn Thr Glu Gly Ser Phe Gln Cys Val Cys Pro Met Gly Phe Gln 
1               5                   10                  15      


Pro Asn Thr Ala Gly Ser Glu Cys Glu Asp Val Asp Glu Cys Glu Asn 
            20                  25                  30          


His Leu Ala Cys Pro Gly Gln Glu Cys Val Asn Ser Pro Gly Ser Phe 
        35                  40                  45              


Gln Cys Arg Thr Cys Pro Ser Gly His His Leu His Arg Gly Arg Cys 
    50                  55                  60                  


Thr Asp Val Asp Glu Cys Ser Ser Gly Ala Pro Pro Cys Gly Pro His 
65                  70                  75                  80  


Gly His Cys Thr Asn Thr Glu Gly Ser Phe Arg Cys Ser Cys Ala Pro 
                85                  90                  95      


Gly Tyr Arg Ala Pro Ser Gly Arg Pro Gly Pro Cys Ala Asp Val Asn 
            100                 105                 110         


Glu Cys Leu Glu Gly Asp Phe Cys Phe Pro His Gly Glu Cys Leu Asn 
        115                 120                 125             


Thr Asp Gly Ser Phe Ala Cys Thr Cys Ala Pro Gly Tyr Arg Pro Gly 
    130                 135                 140                 


Pro Arg Gly Ala Ser Cys Leu Asp Val Asp Glu Cys Ser Glu Glu Asp 
145                 150                 155                 160 


Leu Cys Gln Ser Gly Ile Cys Thr Asn Thr Asp Gly Ser Phe Glu Cys 
                165                 170                 175     


Ile Cys Pro Pro Gly His Arg Ala Gly Pro Asp Leu Ala Ser Cys Leu 
            180                 185                 190         


Asp Val Asp Glu Cys Arg Glu Arg Gly Pro Ala Leu Cys Gly Ser Gln 
        195                 200                 205             


Arg Cys Glu Asn Ser Pro Gly Ser Tyr Arg Cys Val Arg Asp Cys Asp 
    210                 215                 220                 


Pro Gly Tyr His Ala Gly Pro Glu Gly Thr Cys Asp Asp Val Asn Glu 
225                 230                 235                 240 


Cys Glu Thr Leu Gln Gly Val Cys Gly Ala Ala Leu Cys Glu Asn Val 
                245                 250                 255     


Glu Gly Ser Phe Leu Cys Val Cys Pro Asn Ser Pro Glu Glu Phe Asp 
            260                 265                 270         


Pro Met Thr Gly Arg Cys Val Pro Pro Arg Thr Ser Ala Gly Thr Phe 
        275                 280                 285             


Pro Gly Ser Gln Pro Gln Ala Pro Ala Ser Pro Val Leu Pro Ala Arg 
    290                 295                 300                 


Pro Pro Pro Pro Pro Leu Pro Arg Arg Pro Ser Thr Pro Arg Gln Gly 
305                 310                 315                 320 


Pro Val Gly Ser Gly Arg Arg Glu Cys Tyr Phe Asp Thr Ala Ala Pro 
                325                 330                 335     


Asp Ala Cys Asp Asn Ile Leu Ala Arg Asn Val Thr Trp Gln Glu Cys 
            340                 345                 350         


Cys Cys Thr Val Gly Glu Gly Trp Gly Ser Gly Cys Arg Ile Gln Gln 
        355                 360                 365             


Cys Pro Gly Thr Glu Thr Ala Glu Tyr Gln Ser Leu Cys Pro His Gly 
    370                 375                 380                 


Arg Gly Tyr Leu Ala Pro Ser Gly Asp Leu Ser Leu Arg Arg Asp Val 
385                 390                 395                 400 


Asp Glu Cys Gln Leu Phe Arg Asp Gln Val Cys Lys Ser Gly Val Cys 
                405                 410                 415     


Val Asn Thr Ala Pro Gly Tyr Ser Cys Tyr Cys Ser Asn Gly Tyr Tyr 
            420                 425                 430         


Tyr His Thr Gln Arg Leu Glu Cys Ile Asp Asn Asp Glu Cys Ala Asp 
        435                 440                 445             


Glu Glu Pro Ala Cys Glu Gly Gly Arg Cys Val Asn Thr Val Gly Ser 
    450                 455                 460                 


Tyr His Cys Thr Cys Glu Pro Pro Leu Val Leu Asp Gly Ser Gln Arg 
465                 470                 475                 480 


Arg Cys Val Ser Asn Glu Ser Gln Ser Leu Asp Asp Asn Leu Gly Val 
                485                 490                 495     


Cys Trp Gln Glu Val Gly Ala Asp Leu Val Cys Ser His Pro Arg Leu 
            500                 505                 510         


Asp Arg Gln Ala Thr Tyr Thr Glu Cys Cys Cys Leu Tyr Gly Glu Ala 
        515                 520                 525             


Trp Gly Met Asp Cys Ala Leu Cys Pro Ala Gln Asp Ser Asp Asp Phe 
    530                 535                 540                 


Glu Ala Leu Cys Asn Val Leu Arg Pro Pro Ala Tyr Ser Pro Pro Arg 
545                 550                 555                 560 


Pro Gly Gly Phe Gly Leu Pro Tyr Glu Tyr Gly Pro Asp Leu Gly Pro 
                565                 570                 575     


Pro Tyr Gln Gly Leu Pro Tyr Gly Pro Glu Leu Tyr Pro Pro Pro Ala 
            580                 585                 590         


Leu Pro Tyr Asp Pro Tyr Pro Pro Pro Pro Gly Pro Phe Ala Arg Arg 
        595                 600                 605             


Glu Ala Pro Tyr Gly Ala Pro Arg Phe Asp Met Pro Asp Phe Glu Asp 
    610                 615                 620                 


Asp Gly Gly Pro Tyr Gly Glu Ser Glu Ala Pro Ala Pro Pro Gly Pro 
625                 630                 635                 640 


Gly Thr Arg Trp Pro Tyr Arg Ser Arg Asp Thr Arg Arg Ser Phe Pro 
                645                 650                 655     


Glu Pro Glu Glu Pro Pro Glu Gly Gly Ser Tyr Ala Gly Ser Leu Ala 
            660                 665                 670         


Glu Pro 
        


<210>  8134
<211>  94
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8134

Xaa Arg Phe Asp Met Pro Asp Phe Glu Asp Asp Gly Gly Pro Tyr Gly 
1               5                   10                  15      


Glu Ser Glu Ala Glu Glu Cys Gly Ile Leu Asp Gly Cys Thr Asn Gly 
            20                  25                  30          


Arg Cys Val Arg Val Pro Glu Gly Phe Thr Cys Arg Cys Phe Asp Gly 
        35                  40                  45              


Tyr Arg Leu Asp Met Thr Arg Met Ala Cys Val Asp Ile Asn Glu Cys 
    50                  55                  60                  


Asp Glu Ala Glu Ala Ala Ser Pro Leu Cys Val Asn Ala Arg Cys Leu 
65                  70                  75                  80  


Asn Thr Asp Gly Ser Phe Arg Cys Ile Cys Arg Pro Gly Phe 
                85                  90                  


<210>  8135
<211>  957
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8135

Xaa Val Asp Glu Cys Arg Arg Val Pro Pro Pro Cys Ala Pro Gly Arg 
1               5                   10                  15      


Cys Glu Asn Ser Pro Gly Ser Phe Arg Cys Val Cys Gly Pro Gly Phe 
            20                  25                  30          


Arg Ala Gly Pro Arg Ala Ala Glu Cys Leu Asp Val Asp Glu Cys His 
        35                  40                  45              


Arg Val Pro Pro Pro Cys Asp Leu Gly Arg Cys Glu Asn Thr Pro Gly 
    50                  55                  60                  


Ser Phe Leu Cys Val Cys Pro Ala Gly Tyr Gln Ala Ala Pro His Gly 
65                  70                  75                  80  


Ala Ser Cys Gln Asp Val Asp Glu Cys Ala Arg Ser Pro Pro Pro Cys 
                85                  90                  95      


Thr Tyr Gly Arg Cys Glu Asn Thr Glu Gly Ser Phe Gln Cys Val Cys 
            100                 105                 110         


Pro Met Gly Phe Gln Pro Asn Thr Ala Gly Ser Glu Cys Glu Asp Val 
        115                 120                 125             


Asp Glu Cys Glu Asn His Leu Ala Cys Pro Gly Gln Glu Cys Val Asn 
    130                 135                 140                 


Ser Pro Gly Ser Phe Gln Cys Arg Thr Cys Pro Ser Gly His His Leu 
145                 150                 155                 160 


His Arg Gly Arg Cys Thr Asp Val Asp Glu Cys Ser Ser Gly Ala Pro 
                165                 170                 175     


Pro Cys Gly Pro His Gly His Cys Thr Asn Thr Glu Gly Ser Phe Arg 
            180                 185                 190         


Cys Ser Cys Ala Pro Gly Tyr Arg Ala Pro Ser Gly Arg Pro Gly Pro 
        195                 200                 205             


Cys Ala Asp Val Asn Glu Cys Leu Glu Gly Asp Phe Cys Phe Pro His 
    210                 215                 220                 


Gly Glu Cys Leu Asn Thr Asp Gly Ser Phe Ala Cys Thr Cys Ala Pro 
225                 230                 235                 240 


Gly Tyr Arg Pro Gly Pro Arg Gly Ala Ser Cys Leu Asp Val Asp Glu 
                245                 250                 255     


Cys Ser Glu Glu Asp Leu Cys Gln Ser Gly Ile Cys Thr Asn Thr Asp 
            260                 265                 270         


Gly Ser Phe Glu Cys Ile Cys Pro Pro Gly His Arg Ala Gly Pro Asp 
        275                 280                 285             


Leu Ala Ser Cys Leu Asp Val Asp Glu Cys Arg Glu Arg Gly Pro Ala 
    290                 295                 300                 


Leu Cys Gly Ser Gln Arg Cys Glu Asn Ser Pro Gly Ser Tyr Arg Cys 
305                 310                 315                 320 


Val Arg Asp Cys Asp Pro Gly Tyr His Ala Gly Pro Glu Gly Thr Cys 
                325                 330                 335     


Asp Asp Val Asp Glu Cys Gln Glu Tyr Gly Pro Glu Ile Cys Gly Ala 
            340                 345                 350         


Gln Arg Cys Glu Asn Thr Pro Gly Ser Tyr Arg Cys Thr Pro Ala Cys 
        355                 360                 365             


Asp Pro Gly Tyr Gln Pro Thr Pro Gly Gly Gly Cys Gln Asp Val Asp 
    370                 375                 380                 


Glu Cys Arg Asn Arg Ser Phe Cys Gly Ala His Ala Val Cys Gln Asn 
385                 390                 395                 400 


Leu Pro Gly Ser Phe Gln Cys Leu Cys Asp Gln Gly Tyr Glu Gly Ala 
                405                 410                 415     


Arg Asp Gly Arg His Cys Val Asp Val Asn Glu Cys Glu Thr Leu Gln 
            420                 425                 430         


Gly Val Cys Gly Ala Ala Leu Cys Glu Asn Val Glu Gly Ser Phe Leu 
        435                 440                 445             


Cys Val Cys Pro Asn Ser Pro Glu Glu Phe Asp Pro Met Thr Gly Arg 
    450                 455                 460                 


Cys Val Pro Pro Arg Thr Ser Ala Gly Thr Phe Pro Gly Ser Gln Pro 
465                 470                 475                 480 


Gln Ala Pro Ala Ser Pro Val Leu Pro Ala Arg Pro Pro Pro Pro Pro 
                485                 490                 495     


Leu Pro Arg Arg Pro Ser Thr Pro Arg Gln Gly Pro Val Gly Ser Gly 
            500                 505                 510         


Arg Arg Glu Cys Tyr Phe Asp Thr Ala Ala Pro Asp Ala Cys Asp Asn 
        515                 520                 525             


Ile Leu Ala Arg Asn Val Thr Trp Gln Glu Cys Cys Cys Thr Val Gly 
    530                 535                 540                 


Glu Gly Trp Gly Ser Gly Cys Arg Ile Gln Gln Cys Pro Gly Thr Glu 
545                 550                 555                 560 


Thr Ala Glu Tyr Gln Ser Leu Cys Pro His Gly Arg Gly Tyr Leu Ala 
                565                 570                 575     


Pro Ser Gly Asp Leu Ser Leu Arg Arg Asp Val Asp Glu Cys Gln Leu 
            580                 585                 590         


Phe Arg Asp Gln Val Cys Lys Ser Gly Val Cys Val Asn Thr Ala Pro 
        595                 600                 605             


Gly Tyr Ser Cys Tyr Cys Ser Asn Gly Tyr Tyr Tyr His Thr Gln Arg 
    610                 615                 620                 


Leu Glu Cys Ile Asp Asn Asp Glu Cys Ala Asp Glu Glu Pro Ala Cys 
625                 630                 635                 640 


Glu Gly Gly Arg Cys Val Asn Thr Val Gly Ser Tyr His Cys Thr Cys 
                645                 650                 655     


Glu Pro Pro Leu Val Leu Asp Gly Ser Gln Arg Arg Cys Val Ser Asn 
            660                 665                 670         


Glu Ser Gln Ser Leu Asp Asp Asn Leu Gly Val Cys Trp Gln Glu Val 
        675                 680                 685             


Gly Ala Asp Leu Val Cys Ser His Pro Arg Leu Asp Arg Gln Ala Thr 
    690                 695                 700                 


Tyr Thr Glu Cys Cys Cys Leu Tyr Gly Glu Ala Trp Gly Met Asp Cys 
705                 710                 715                 720 


Ala Leu Cys Pro Ala Gln Asp Ser Asp Asp Phe Glu Ala Leu Cys Asn 
                725                 730                 735     


Val Leu Arg Pro Pro Ala Tyr Ser Pro Pro Arg Pro Gly Gly Phe Gly 
            740                 745                 750         


Leu Pro Tyr Glu Tyr Gly Pro Asp Leu Gly Pro Pro Tyr Gln Gly Leu 
        755                 760                 765             


Pro Tyr Gly Pro Glu Leu Tyr Pro Pro Pro Ala Leu Pro Tyr Asp Pro 
    770                 775                 780                 


Tyr Pro Pro Pro Pro Gly Pro Phe Ala Arg Arg Glu Ala Pro Tyr Gly 
785                 790                 795                 800 


Ala Pro Arg Phe Asp Met Pro Asp Phe Glu Asp Asp Gly Gly Pro Tyr 
                805                 810                 815     


Gly Glu Ser Glu Ala Pro Ala Pro Pro Gly Pro Gly Thr Arg Trp Pro 
            820                 825                 830         


Tyr Arg Ser Arg Asp Thr Arg Arg Ser Phe Pro Glu Pro Glu Glu Pro 
        835                 840                 845             


Pro Glu Gly Gly Ser Tyr Ala Gly Ser Leu Ala Glu Pro Tyr Glu Glu 
    850                 855                 860                 


Leu Glu Ala Glu Glu Cys Gly Ile Leu Asp Gly Cys Thr Asn Gly Arg 
865                 870                 875                 880 


Cys Val Arg Val Pro Glu Gly Phe Thr Cys Arg Cys Phe Asp Gly Tyr 
                885                 890                 895     


Arg Leu Asp Met Thr Arg Met Ala Cys Val Asp Ile Asn Glu Cys Asp 
            900                 905                 910         


Glu Ala Glu Ala Ala Ser Pro Leu Cys Val Asn Ala Arg Cys Leu Asn 
        915                 920                 925             


Thr Asp Gly Ser Phe Arg Cys Ile Cys Arg Pro Gly Phe Ala Pro Thr 
    930                 935                 940                 


His Gln Pro His His Cys Ala Pro Ala Arg Pro Arg Ala 
945                 950                 955         


<210>  8136
<211>  191
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8136

Xaa Val Asp Glu Cys Ser Glu Glu Asp Leu Cys Gln Ser Gly Ile Cys 
1               5                   10                  15      


Thr Asn Thr Asp Gly Ser Phe Glu Cys Ile Cys Pro Pro Gly His Arg 
            20                  25                  30          


Ala Gly Pro Asp Leu Ala Ser Cys Leu Asp Val Asp Glu Cys Arg Glu 
        35                  40                  45              


Arg Gly Pro Ala Leu Cys Gly Ser Gln Arg Cys Glu Asn Ser Pro Gly 
    50                  55                  60                  


Ser Tyr Arg Cys Val Arg Asp Cys Asp Pro Gly Tyr His Ala Gly Pro 
65                  70                  75                  80  


Glu Gly Thr Cys Asp Asp Val Asp Glu Cys Gln Glu Tyr Gly Pro Glu 
                85                  90                  95      


Ile Cys Gly Ala Gln Arg Cys Glu Asn Thr Pro Gly Ser Tyr Arg Cys 
            100                 105                 110         


Thr Pro Ala Cys Asp Pro Gly Tyr Gln Pro Thr Pro Gly Gly Gly Cys 
        115                 120                 125             


Gln Asp Val Asn Glu Cys Glu Thr Leu Gln Gly Val Cys Gly Ala Ala 
    130                 135                 140                 


Leu Cys Glu Asn Val Glu Gly Ser Phe Leu Cys Val Cys Pro Asn Ser 
145                 150                 155                 160 


Pro Glu Glu Phe Asp Pro Met Thr Gly Arg Cys Val Pro Pro Arg Thr 
                165                 170                 175     


Ser Ala Asp Val Asp Glu Cys Gln Leu Phe Arg Asp Gln Val Cys 
            180                 185                 190     


<210>  8137
<211>  189
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8137

Xaa Val Asp Glu Cys Ser Glu Glu Asp Leu Cys Gln Ser Gly Ile Cys 
1               5                   10                  15      


Thr Asn Thr Asp Gly Ser Phe Glu Cys Ile Cys Pro Pro Gly His Arg 
            20                  25                  30          


Ala Gly Pro Asp Leu Ala Ser Cys Leu Asp Val Asp Glu Cys Arg Glu 
        35                  40                  45              


Arg Gly Pro Ala Leu Cys Gly Ser Gln Arg Cys Glu Asn Ser Pro Gly 
    50                  55                  60                  


Ser Tyr Arg Cys Val Arg Asp Cys Asp Pro Gly Tyr His Ala Gly Pro 
65                  70                  75                  80  


Glu Gly Thr Cys Asp Asp Val Asp Glu Cys Arg Asn Arg Ser Phe Cys 
                85                  90                  95      


Gly Ala His Ala Val Cys Gln Asn Leu Pro Gly Ser Phe Gln Cys Leu 
            100                 105                 110         


Cys Asp Gln Gly Tyr Glu Gly Ala Arg Asp Gly Arg His Cys Val Asp 
        115                 120                 125             


Val Asn Glu Cys Glu Thr Leu Gln Gly Val Cys Gly Ala Ala Leu Cys 
    130                 135                 140                 


Glu Asn Val Glu Gly Ser Phe Leu Cys Val Cys Pro Asn Ser Pro Glu 
145                 150                 155                 160 


Glu Phe Asp Pro Met Thr Gly Arg Cys Val Pro Pro Arg Thr Ser Ala 
                165                 170                 175     


Gly Thr Phe Pro Gly Ser Gln Pro Gln Ala Pro Ala Ser 
            180                 185                 


<210>  8138
<211>  416
<212>  PRT
<213>  Homo Sapiens

<400>  8138

Met Glu Ala Thr Gly Ile Ser Leu Ala Ser Gln Leu Lys Val Pro Pro 
1               5                   10                  15      


Tyr Ala Ser Glu Asn Gln Thr Cys Arg Asp Gln Glu Lys Glu Tyr Tyr 
            20                  25                  30          


Glu Pro Gln His Arg Ile Cys Cys Ser Arg Cys Pro Pro Gly Thr Tyr 
        35                  40                  45              


Val Ser Ala Lys Cys Ser Arg Ile Arg Asp Thr Val Cys Ala Thr Cys 
    50                  55                  60                  


Ala Glu Asn Ser Tyr Asn Glu His Trp Asn Tyr Leu Thr Ile Cys Gln 
65                  70                  75                  80  


Leu Cys Arg Pro Cys Asp Pro Val Met Gly Leu Glu Glu Ile Ala Pro 
                85                  90                  95      


Cys Thr Ser Lys Arg Lys Thr Gln Cys Arg Cys Gln Pro Gly Met Phe 
            100                 105                 110         


Cys Ala Ala Trp Ala Leu Glu Cys Thr His Cys Glu Leu Leu Ser Asp 
        115                 120                 125             


Cys Pro Pro Gly Thr Glu Ala Glu Leu Lys Asp Glu Val Gly Lys Gly 
    130                 135                 140                 


Asn Asn His Cys Val Pro Cys Lys Ala Gly His Phe Gln Asn Thr Ser 
145                 150                 155                 160 


Ser Pro Ser Ala Arg Cys Gln Pro His Thr Arg Cys Glu Asn Gln Gly 
                165                 170                 175     


Leu Val Glu Ala Ala Pro Gly Thr Ala Gln Ser Asp Thr Thr Cys Lys 
            180                 185                 190         


Asn Pro Leu Glu Pro Leu Pro Pro Glu Met Ser Gly Thr Met Leu Met 
        195                 200                 205             


Leu Ala Val Leu Leu Pro Leu Ala Phe Phe Leu Leu Leu Ala Thr Val 
    210                 215                 220                 


Phe Ser Cys Ile Trp Lys Ser His Pro Ser Leu Cys Arg Lys Leu Gly 
225                 230                 235                 240 


Ser Leu Leu Lys Arg Arg Pro Gln Gly Glu Gly Pro Asn Pro Val Ala 
                245                 250                 255     


Gly Ser Trp Glu Pro Pro Lys Ala His Pro Tyr Phe Pro Asp Leu Val 
            260                 265                 270         


Gln Pro Leu Leu Pro Ile Ser Gly Asp Val Ser Pro Val Ser Thr Gly 
        275                 280                 285             


Leu Pro Ala Ala Pro Val Leu Glu Ala Gly Val Pro Gln Gln Gln Ser 
    290                 295                 300                 


Pro Leu Asp Leu Thr Arg Glu Pro Gln Leu Glu Pro Gly Glu Gln Ser 
305                 310                 315                 320 


Gln Val Ala His Gly Thr Asn Gly Ile His Val Thr Gly Gly Ser Met 
                325                 330                 335     


Thr Ile Thr Gly Asn Ile Tyr Ile Tyr Asn Gly Pro Val Leu Gly Gly 
            340                 345                 350         


Pro Pro Gly Pro Gly Asp Leu Pro Ala Thr Pro Glu Pro Pro Tyr Pro 
        355                 360                 365             


Ile Pro Glu Glu Gly Asp Pro Gly Pro Pro Gly Leu Ser Thr Pro His 
    370                 375                 380                 


Gln Glu Asp Gly Lys Ala Trp His Leu Ala Glu Thr Glu His Cys Gly 
385                 390                 395                 400 


Ala Thr Pro Ser Asn Arg Gly Pro Arg Asn Gln Phe Ile Thr His Asp 
                405                 410                 415     


<210>  8139
<211>  148
<212>  PRT
<213>  Homo Sapiens

<400>  8139

Met Gly Leu Glu Glu Ile Ala Pro Cys Thr Ser Lys Arg Lys Thr Gln 
1               5                   10                  15      


Cys Arg Cys Gln Pro Gly Met Phe Cys Ala Ala Trp Ala Leu Glu Cys 
            20                  25                  30          


Thr His Cys Glu Leu Leu Ser Asp Cys Pro Pro Gly Thr Glu Ala Glu 
        35                  40                  45              


Leu Lys Asp Glu Val Gly Lys Gly Asn Asn His Cys Val Pro Cys Lys 
    50                  55                  60                  


Ala Gly His Phe Gln Asn Thr Ser Ser Pro Ser Ala Arg Cys Gln Pro 
65                  70                  75                  80  


His Thr Arg Cys Glu Asn Gln Gly Leu Val Glu Ala Ala Pro Gly Thr 
                85                  90                  95      


Ala Gln Ser Asp Thr Thr Cys Lys Asn Pro Leu Glu Pro Leu Pro Pro 
            100                 105                 110         


Glu Met Ser Glu Pro Ala Leu Ser Lys Gly Val Glu Asn Leu Gln Ala 
        115                 120                 125             


Leu Leu Tyr Gln Ala Ala Thr Gly Ser Ser Glu Ala Ser Phe Pro Thr 
    130                 135                 140                 


Leu Ser Pro Leu 
145             


<210>  8140
<211>  292
<212>  PRT
<213>  Homo Sapiens

<400>  8140

Met Gly Leu Glu Glu Ile Ala Pro Cys Thr Ser Lys Arg Lys Thr Gln 
1               5                   10                  15      


Cys Arg Cys Gln Pro Gly Met Phe Cys Ala Ala Trp Ala Leu Glu Cys 
            20                  25                  30          


Thr His Cys Glu Leu Leu Ser Asp Cys Pro Pro Gly Thr Glu Ala Glu 
        35                  40                  45              


Leu Lys Asp Glu Val Gly Lys Gly Asn Asn His Cys Val Pro Cys Lys 
    50                  55                  60                  


Ala Gly His Phe Gln Asn Thr Ser Ser Pro Ser Ala Arg Cys Gln Pro 
65                  70                  75                  80  


His Thr Arg Cys Glu Asn Gln Gly Leu Val Glu Ala Ala Pro Gly Thr 
                85                  90                  95      


Ala Gln Ser Asp Thr Thr Cys Lys Asn Pro Leu Glu Pro Leu Pro Pro 
            100                 105                 110         


Glu Met Ser Gly Ser Leu Leu Lys Arg Arg Pro Gln Gly Glu Gly Pro 
        115                 120                 125             


Asn Pro Val Ala Gly Ser Trp Glu Pro Pro Lys Ala His Pro Tyr Phe 
    130                 135                 140                 


Pro Asp Leu Val Gln Pro Leu Leu Pro Ile Ser Gly Asp Val Ser Pro 
145                 150                 155                 160 


Val Ser Thr Gly Leu Pro Ala Ala Pro Val Leu Glu Ala Gly Val Pro 
                165                 170                 175     


Gln Gln Gln Ser Pro Leu Asp Leu Thr Arg Glu Pro Gln Leu Glu Pro 
            180                 185                 190         


Gly Glu Gln Ser Gln Val Ala His Gly Thr Asn Gly Ile His Val Thr 
        195                 200                 205             


Gly Gly Ser Met Thr Ile Thr Gly Asn Ile Tyr Ile Tyr Asn Gly Pro 
    210                 215                 220                 


Val Leu Gly Gly Pro Pro Gly Pro Gly Asp Leu Pro Ala Thr Pro Glu 
225                 230                 235                 240 


Pro Pro Tyr Pro Ile Pro Glu Glu Gly Asp Pro Gly Pro Pro Gly Leu 
                245                 250                 255     


Ser Thr Pro His Gln Glu Asp Gly Lys Ala Trp His Leu Ala Glu Thr 
            260                 265                 270         


Glu His Cys Gly Ala Thr Pro Ser Asn Arg Gly Pro Arg Asn Gln Phe 
        275                 280                 285             


Ile Thr His Asp 
    290         


<210>  8141
<211>  74
<212>  PRT
<213>  Homo Sapiens

<400>  8141

Met Gly Leu Glu Glu Ile Ala Pro Cys Thr Ser Lys Arg Lys Thr Gln 
1               5                   10                  15      


Cys Arg Cys Gln Pro Gly Met Phe Cys Ala Ala Trp Ala Leu Glu Cys 
            20                  25                  30          


Thr His Cys Glu Leu Leu Ser Asp Cys Pro Pro Gly Thr Glu Ala Glu 
        35                  40                  45              


Leu Lys Gly Val Arg Thr Lys Val Trp Trp Arg Gln Leu Gln Ala Leu 
    50                  55                  60                  


Pro Ser Pro Thr Gln Pro Ala Lys Ile His 
65                  70                  


<210>  8142
<211>  218
<212>  PRT
<213>  Homo Sapiens

<400>  8142

Met Leu Leu Pro Trp Ala Thr Ser Ala Pro Gly Leu Ala Trp Gly Pro 
1               5                   10                  15      


Leu Val Leu Gly Leu Phe Gly Leu Leu Ala Ala Ser Gln Pro Gln Ala 
            20                  25                  30          


Val Pro Pro Tyr Ala Ser Glu Asn Gln Thr Cys Arg Asp Gln Glu Lys 
        35                  40                  45              


Glu Tyr Tyr Glu Pro Gln His Arg Ile Cys Cys Ser Arg Cys Pro Pro 
    50                  55                  60                  


Ala Lys Cys Ser Arg Ile Arg Asp Thr Val Cys Ala Thr Cys Ala Glu 
65                  70                  75                  80  


Asn Ser Tyr Asn Glu His Trp Asn Tyr Leu Thr Ile Cys Gln Leu Cys 
                85                  90                  95      


Arg Pro Cys Asp Pro Val Met Gly Leu Glu Glu Ile Ala Pro Cys Thr 
            100                 105                 110         


Ser Lys Arg Lys Thr Gln Cys Arg Cys Gln Pro Gly Met Phe Cys Ala 
        115                 120                 125             


Ala Trp Ala Leu Glu Cys Thr His Cys Glu Leu Leu Ser Asp Cys Pro 
    130                 135                 140                 


Pro Gly Thr Glu Ala Glu Leu Lys Asp Glu Val Gly Lys Gly Asn Asn 
145                 150                 155                 160 


His Cys Val Pro Cys Lys Ala Gly His Phe Gln Asn Thr Ser Ser Pro 
                165                 170                 175     


Ser Ala Arg Cys Gln Pro His Thr Arg Cys Glu Asn Gln Gly Leu Val 
            180                 185                 190         


Glu Ala Ala Pro Gly Thr Ala Gln Ser Asp Thr Thr Cys Lys Asn Pro 
        195                 200                 205             


Leu Glu Pro Leu Pro Pro Glu Met Ser Gly 
    210                 215             


<210>  8143
<211>  435
<212>  PRT
<213>  Homo Sapiens

<400>  8143

Met Leu Leu Pro Trp Ala Thr Ser Ala Pro Gly Leu Ala Trp Gly Pro 
1               5                   10                  15      


Leu Val Leu Gly Leu Phe Gly Leu Leu Ala Ala Ser Gln Pro Gln Ala 
            20                  25                  30          


Val Pro Pro Tyr Ala Ser Glu Asn Gln Thr Cys Arg Asp Gln Glu Lys 
        35                  40                  45              


Glu Tyr Tyr Glu Pro Gln His Arg Ile Cys Cys Ser Arg Cys Pro Pro 
    50                  55                  60                  


Gly Thr Tyr Val Ser Ala Lys Cys Ser Arg Ile Arg Asp Thr Val Cys 
65                  70                  75                  80  


Ala Thr Cys Ala Glu Asn Ser Tyr Asn Glu His Trp Asn Tyr Leu Thr 
                85                  90                  95      


Ile Cys Gln Leu Cys Arg Pro Cys Asp Pro Val Met Gly Leu Glu Glu 
            100                 105                 110         


Ile Ala Pro Cys Thr Ser Lys Arg Lys Thr Gln Cys Arg Cys Gln Pro 
        115                 120                 125             


Gly Met Phe Cys Ala Ala Trp Ala Leu Glu Cys Thr His Cys Glu Leu 
    130                 135                 140                 


Leu Ser Asp Cys Pro Pro Gly Thr Glu Ala Glu Leu Lys Asp Glu Val 
145                 150                 155                 160 


Gly Lys Gly Asn Asn His Cys Val Pro Cys Lys Ala Gly His Phe Gln 
                165                 170                 175     


Asn Thr Ser Ser Pro Ser Ala Arg Cys Gln Pro His Thr Arg Cys Glu 
            180                 185                 190         


Asn Gln Gly Leu Val Glu Ala Ala Pro Gly Thr Ala Gln Ser Asp Thr 
        195                 200                 205             


Thr Cys Lys Asn Pro Leu Glu Pro Leu Pro Pro Glu Met Ser Gly Thr 
    210                 215                 220                 


Met Leu Met Leu Ala Val Leu Leu Pro Leu Ala Phe Phe Leu Leu Leu 
225                 230                 235                 240 


Ala Thr Val Phe Ser Cys Ile Trp Lys Ser His Pro Ser Leu Cys Arg 
                245                 250                 255     


Lys Leu Gly Ser Leu Leu Lys Arg Arg Pro Gln Gly Glu Gly Pro Asn 
            260                 265                 270         


Pro Val Ala Gly Ser Trp Glu Pro Pro Lys Ala His Pro Tyr Phe Pro 
        275                 280                 285             


Asp Leu Val Gln Pro Leu Leu Pro Ile Ser Gly Asp Val Ser Pro Val 
    290                 295                 300                 


Ser Thr Gly Leu Pro Ala Ala Pro Val Leu Glu Ala Gly Val Pro Gln 
305                 310                 315                 320 


Gln Gln Ser Pro Leu Asp Leu Thr Arg Glu Pro Gln Leu Glu Pro Gly 
                325                 330                 335     


Glu Gln Ser Gln Val Ala His Gly Thr Asn Gly Ile His Val Thr Gly 
            340                 345                 350         


Gly Ser Met Thr Ile Thr Gly Asn Ile Tyr Ile Tyr Asn Gly Pro Val 
        355                 360                 365             


Leu Gly Gly Pro Pro Gly Pro Gly Asp Leu Pro Ala Thr Pro Glu Pro 
    370                 375                 380                 


Pro Tyr Pro Ile Pro Glu Glu Gly Asp Pro Gly Pro Pro Gly Leu Ser 
385                 390                 395                 400 


Thr Pro His Gln Glu Asp Gly Lys Ala Trp His Leu Ala Glu Thr Glu 
                405                 410                 415     


His Cys Gly Ala Thr Pro Ser Asn Arg Gly Pro Arg Asn Gln Phe Ile 
            420                 425                 430         


Thr His Asp 
        435 


<210>  8144
<211>  696
<212>  PRT
<213>  Homo Sapiens

<400>  8144

Met Gly Leu Cys Leu Ala Gly Arg Arg Arg Ser Val Gln Trp Cys Ala 
1               5                   10                  15      


Val Ser Gln Pro Glu Ala Thr Lys Cys Phe Gln Trp Gln Arg Asn Met 
            20                  25                  30          


Arg Lys Val Arg Gly Pro Pro Val Ser Cys Ile Lys Arg Asp Ser Pro 
        35                  40                  45              


Ile Gln Cys Ile Gln Ala Ile Ala Glu Asn Arg Ala Asp Ala Val Thr 
    50                  55                  60                  


Leu Asp Gly Gly Phe Ile Tyr Glu Ala Gly Leu Ala Pro Tyr Lys Leu 
65                  70                  75                  80  


Arg Pro Val Ala Ala Glu Val Tyr Gly Thr Glu Arg Gln Pro Arg Thr 
                85                  90                  95      


His Tyr Tyr Ala Val Ala Val Val Lys Lys Gly Gly Ser Phe Gln Leu 
            100                 105                 110         


Asn Glu Leu Gln Gly Leu Lys Ser Cys His Thr Gly Leu Arg Arg Thr 
        115                 120                 125             


Ala Gly Trp Asn Val Pro Ile Gly Thr Leu Arg Pro Phe Leu Asn Trp 
    130                 135                 140                 


Thr Gly Pro Pro Glu Pro Ile Glu Ala Ala Val Ala Arg Phe Phe Ser 
145                 150                 155                 160 


Ala Ser Cys Val Pro Gly Ala Asp Lys Gly Gln Phe Pro Asn Leu Cys 
                165                 170                 175     


Arg Leu Cys Ala Gly Thr Gly Glu Asn Lys Cys Ala Phe Ser Ser Gln 
            180                 185                 190         


Glu Pro Tyr Phe Ser Tyr Ser Gly Ala Phe Lys Cys Leu Arg Asp Gly 
        195                 200                 205             


Ala Gly Asp Val Ala Phe Ile Arg Glu Ser Thr Val Phe Glu Asp Leu 
    210                 215                 220                 


Ser Asp Glu Ala Glu Arg Asp Glu Tyr Glu Leu Leu Cys Pro Asp Asn 
225                 230                 235                 240 


Thr Arg Lys Pro Val Asp Lys Phe Lys Asp Cys His Leu Ala Arg Val 
                245                 250                 255     


Pro Ser His Ala Val Val Ala Arg Ser Val Asn Gly Lys Glu Asp Ala 
            260                 265                 270         


Ile Trp Asn Leu Leu Arg Gln Ala Gln Glu Lys Phe Gly Lys Asp Lys 
        275                 280                 285             


Ser Pro Lys Phe Gln Leu Phe Gly Ser Pro Ser Gly Gln Lys Asp Leu 
    290                 295                 300                 


Leu Phe Lys Asp Ser Ala Ile Gly Phe Ser Arg Val Pro Pro Arg Ile 
305                 310                 315                 320 


Asp Ser Gly Leu Tyr Leu Gly Ser Gly Tyr Phe Thr Ala Ile Gln Asn 
                325                 330                 335     


Leu Arg Lys Ser Glu Glu Glu Val Ala Ala Arg Arg Ala Arg Val Val 
            340                 345                 350         


Trp Cys Ala Val Gly Glu Gln Glu Leu Arg Lys Cys Asn Gln Trp Ser 
        355                 360                 365             


Gly Leu Ser Glu Gly Ser Val Thr Cys Ser Ser Ala Ser Thr Thr Glu 
    370                 375                 380                 


Asp Cys Ile Ala Leu Val Leu Lys Gly Glu Ala Asp Ala Met Ser Leu 
385                 390                 395                 400 


Asp Gly Gly Tyr Val Tyr Thr Ala Gly Lys Cys Gly Leu Val Pro Val 
                405                 410                 415     


Leu Ala Glu Asn Tyr Lys Ser Gln Gln Ser Ser Asp Pro Asp Pro Asn 
            420                 425                 430         


Cys Val Asp Arg Pro Val Glu Gly Tyr Leu Ala Val Ala Val Val Arg 
        435                 440                 445             


Arg Ser Asp Thr Ser Leu Thr Trp Asn Ser Val Lys Gly Lys Lys Ser 
    450                 455                 460                 


Cys His Thr Ala Val Asp Arg Thr Ala Gly Trp Asn Ile Pro Met Gly 
465                 470                 475                 480 


Leu Leu Phe Asn Gln Thr Gly Ser Cys Lys Phe Asp Glu Tyr Phe Ser 
                485                 490                 495     


Gln Ser Cys Ala Pro Gly Ser Asp Pro Arg Ser Asn Leu Cys Ala Leu 
            500                 505                 510         


Cys Ile Gly Asp Glu Gln Gly Glu Asn Lys Cys Val Pro Asn Ser Asn 
        515                 520                 525             


Glu Arg Tyr Tyr Gly Tyr Thr Gly Ala Phe Arg Cys Leu Ala Glu Asn 
    530                 535                 540                 


Ala Gly Asp Val Ala Phe Val Lys Asp Val Thr Val Leu Gln Asn Thr 
545                 550                 555                 560 


Asp Gly Asn Asn Asn Glu Ala Trp Ala Lys Asp Leu Lys Leu Ala Asp 
                565                 570                 575     


Phe Ala Leu Leu Cys Leu Asp Gly Lys Arg Lys Pro Val Thr Glu Ala 
            580                 585                 590         


Arg Ser Cys His Leu Ala Met Ala Pro Asn His Ala Val Val Ser Arg 
        595                 600                 605             


Met Asp Lys Val Glu Arg Leu Lys Gln Val Leu Leu His Gln Gln Ala 
    610                 615                 620                 


Lys Phe Gly Arg Asn Gly Ser Asp Cys Pro Asp Lys Phe Cys Leu Phe 
625                 630                 635                 640 


Gln Ser Glu Thr Lys Asn Leu Leu Phe Asn Asp Asn Thr Glu Cys Leu 
                645                 650                 655     


Ala Arg Leu His Gly Lys Thr Thr Tyr Glu Lys Tyr Leu Gly Pro Gln 
            660                 665                 670         


Tyr Val Ala Gly Ile Thr Asn Leu Lys Lys Cys Ser Thr Ser Pro Leu 
        675                 680                 685             


Leu Glu Ala Cys Glu Phe Leu Arg 
    690                 695     


<210>  8145
<211>  182
<212>  PRT
<213>  Homo Sapiens

<400>  8145

Met Lys Leu Val Phe Leu Val Leu Leu Phe Leu Gly Ala Leu Gly Phe 
1               5                   10                  15      


Leu Trp Met Pro Phe Ile Arg Gln Pro Gly Leu Cys Leu Ala Gly Arg 
            20                  25                  30          


Arg Arg Ser Val Gln Trp Cys Ala Val Ser Gln Pro Glu Ala Thr Lys 
        35                  40                  45              


Cys Phe Gln Trp Gln Arg Asn Met Arg Lys Val Arg Gly Pro Pro Val 
    50                  55                  60                  


Ser Cys Ile Lys Arg Asp Ser Pro Ile Gln Cys Ile Gln Ala Ile Ala 
65                  70                  75                  80  


Glu Asn Arg Ala Asp Ala Val Thr Leu Asp Gly Gly Phe Ile Tyr Glu 
                85                  90                  95      


Ala Gly Leu Ala Pro Tyr Lys Leu Arg Pro Val Ala Ala Glu Val Tyr 
            100                 105                 110         


Gly Thr Glu Arg Gln Pro Arg Thr His Tyr Tyr Ala Val Ala Val Val 
        115                 120                 125             


Lys Lys Gly Gly Ser Phe Gln Leu Asn Glu Leu Gln Gly Leu Lys Ser 
    130                 135                 140                 


Cys His Thr Gly Leu Arg Arg Thr Ala Gly Trp Asn Val Pro Ile Gly 
145                 150                 155                 160 


Thr Leu Arg Pro Phe Leu Asn Trp Thr Gly Pro Pro Glu Pro Ile Glu 
                165                 170                 175     


Ala Ala Val Ala Arg Phe 
            180         


<210>  8146
<211>  710
<212>  PRT
<213>  Homo Sapiens

<400>  8146

Met Lys Leu Val Phe Leu Val Leu Leu Phe Leu Gly Ala Leu Gly Leu 
1               5                   10                  15      


Cys Leu Ala Gly Arg Arg Arg Ser Val Gln Trp Cys Ala Val Ser Gln 
            20                  25                  30          


Pro Glu Ala Thr Lys Cys Phe Gln Trp Gln Arg Asn Met Arg Lys Val 
        35                  40                  45              


Arg Gly Pro Pro Val Ser Cys Ile Lys Arg Asp Ser Pro Ile Gln Cys 
    50                  55                  60                  


Ile Gln Ala Ile Ala Glu Asn Arg Ala Asp Ala Val Thr Leu Asp Gly 
65                  70                  75                  80  


Gly Phe Ile Tyr Glu Ala Gly Leu Ala Pro Tyr Lys Leu Arg Pro Val 
                85                  90                  95      


Ala Ala Glu Val Tyr Gly Thr Glu Arg Gln Pro Arg Thr His Tyr Tyr 
            100                 105                 110         


Ala Val Ala Val Val Lys Lys Gly Gly Ser Phe Gln Leu Asn Glu Leu 
        115                 120                 125             


Gln Gly Leu Lys Ser Cys His Thr Gly Leu Arg Arg Thr Ala Gly Trp 
    130                 135                 140                 


Asn Val Pro Ile Gly Thr Leu Arg Pro Phe Leu Asn Trp Thr Gly Pro 
145                 150                 155                 160 


Pro Glu Pro Ile Glu Ala Ala Val Ala Arg Phe Phe Ser Ala Ser Cys 
                165                 170                 175     


Val Pro Gly Ala Asp Lys Gly Gln Phe Pro Asn Leu Cys Arg Leu Cys 
            180                 185                 190         


Ala Gly Thr Gly Glu Asn Lys Cys Ala Phe Ser Ser Gln Glu Pro Tyr 
        195                 200                 205             


Phe Ser Tyr Ser Gly Ala Phe Lys Cys Leu Arg Asp Gly Ala Gly Asp 
    210                 215                 220                 


Val Ala Phe Ile Arg Glu Ser Thr Val Phe Glu Asp Leu Ser Asp Glu 
225                 230                 235                 240 


Ala Glu Arg Asp Glu Tyr Glu Leu Leu Cys Pro Asp Asn Thr Arg Lys 
                245                 250                 255     


Pro Val Asp Lys Phe Lys Asp Cys His Leu Ala Arg Val Pro Ser His 
            260                 265                 270         


Ala Val Val Ala Arg Ser Val Asn Gly Lys Glu Asp Ala Ile Trp Asn 
        275                 280                 285             


Leu Leu Arg Gln Ala Gln Glu Lys Phe Gly Lys Asp Lys Ser Pro Lys 
    290                 295                 300                 


Phe Gln Leu Phe Gly Ser Pro Ser Gly Gln Lys Asp Leu Leu Phe Lys 
305                 310                 315                 320 


Asp Ser Ala Ile Gly Phe Ser Arg Val Pro Pro Arg Ile Asp Ser Gly 
                325                 330                 335     


Leu Tyr Leu Gly Ser Gly Tyr Phe Thr Ala Ile Gln Asn Leu Arg Lys 
            340                 345                 350         


Ser Glu Glu Glu Val Ala Ala Arg Arg Ala Arg Val Val Trp Cys Ala 
        355                 360                 365             


Val Gly Glu Gln Glu Leu Arg Lys Cys Asn Gln Trp Ser Gly Leu Ser 
    370                 375                 380                 


Glu Gly Ser Val Thr Cys Ser Ser Ala Ser Thr Thr Glu Asp Cys Ile 
385                 390                 395                 400 


Ala Leu Val Leu Lys Gly Glu Ala Asp Ala Met Ser Leu Asp Gly Gly 
                405                 410                 415     


Tyr Val Tyr Thr Ala Gly Lys Cys Gly Leu Val Pro Val Leu Ala Glu 
            420                 425                 430         


Asn Tyr Lys Ser Gln Gln Ser Ser Asp Pro Asp Pro Asn Cys Val Asp 
        435                 440                 445             


Arg Pro Val Glu Gly Tyr Leu Ala Val Ala Val Val Arg Arg Ser Asp 
    450                 455                 460                 


Thr Ser Leu Thr Trp Asn Ser Val Lys Gly Lys Lys Ser Cys His Thr 
465                 470                 475                 480 


Ala Val Asp Arg Thr Ala Gly Trp Asn Ile Pro Met Gly Leu Leu Phe 
                485                 490                 495     


Asn Gln Thr Gly Ser Cys Lys Phe Asp Glu Tyr Phe Ser Gln Ser Cys 
            500                 505                 510         


Ala Pro Gly Ser Asp Pro Arg Ser Asn Leu Cys Ala Leu Cys Ile Gly 
        515                 520                 525             


Asp Glu Gln Gly Glu Asn Lys Cys Val Pro Asn Ser Asn Glu Arg Tyr 
    530                 535                 540                 


Tyr Gly Tyr Thr Gly Ala Phe Arg Cys Leu Ala Glu Asn Ala Gly Asp 
545                 550                 555                 560 


Val Ala Phe Val Lys Asp Val Thr Val Leu Gln Asn Thr Asp Gly Asn 
                565                 570                 575     


Asn Asn Glu Ala Trp Ala Lys Asp Leu Lys Leu Ala Asp Phe Ala Leu 
            580                 585                 590         


Leu Cys Leu Asp Gly Lys Arg Lys Pro Val Thr Glu Ala Arg Ser Cys 
        595                 600                 605             


His Leu Ala Met Ala Pro Asn His Ala Val Val Ser Arg Met Asp Lys 
    610                 615                 620                 


Val Glu Arg Leu Lys Gln Val Leu Leu His Gln Gln Ala Lys Phe Gly 
625                 630                 635                 640 


Arg Asn Gly Ser Asp Cys Pro Asp Lys Phe Cys Leu Phe Gln Ser Glu 
                645                 650                 655     


Thr Lys Asn Leu Leu Phe Asn Asp Asn Thr Glu Cys Leu Ala Arg Leu 
            660                 665                 670         


His Gly Lys Thr Thr Tyr Glu Lys Tyr Leu Gly Pro Gln Tyr Val Ala 
        675                 680                 685             


Gly Ile Thr Asn Leu Lys Lys Cys Ser Thr Ser Pro Leu Leu Glu Ala 
    690                 695                 700                 


Cys Glu Phe Leu Arg Lys 
705                 710 


<210>  8147
<211>  708
<212>  PRT
<213>  Homo Sapiens

<400>  8147

Met Lys Leu Val Phe Leu Val Leu Leu Phe Leu Gly Ala Leu Gly Leu 
1               5                   10                  15      


Cys Leu Ala Gly Arg Arg Arg Ser Val Gln Trp Cys Ala Val Ser Gln 
            20                  25                  30          


Pro Glu Ala Thr Lys Cys Phe Gln Trp Gln Arg Asn Met Arg Lys Val 
        35                  40                  45              


Arg Gly Pro Pro Val Ser Cys Ile Lys Arg Asp Ser Pro Ile Gln Cys 
    50                  55                  60                  


Ile Gln Ala Ile Ala Glu Asn Arg Ala Asp Ala Val Thr Leu Asp Gly 
65                  70                  75                  80  


Gly Phe Ile Tyr Glu Ala Gly Leu Ala Pro Tyr Lys Leu Arg Pro Val 
                85                  90                  95      


Ala Ala Glu Val Tyr Gly Thr Glu Arg Gln Pro Arg Thr His Tyr Tyr 
            100                 105                 110         


Ala Val Ala Val Val Lys Lys Gly Gly Ser Phe Gln Leu Asn Glu Leu 
        115                 120                 125             


Gln Gly Leu Lys Ser Cys His Thr Gly Leu Arg Arg Thr Ala Gly Trp 
    130                 135                 140                 


Asn Val Pro Ile Gly Thr Leu Arg Pro Phe Leu Asn Trp Thr Gly Pro 
145                 150                 155                 160 


Pro Glu Pro Ile Glu Ala Ala Val Ala Arg Phe Phe Ser Ala Ser Cys 
                165                 170                 175     


Val Pro Gly Ala Asp Lys Gly Gln Phe Pro Asn Leu Cys Arg Leu Cys 
            180                 185                 190         


Ala Gly Thr Gly Glu Asn Lys Cys Ala Phe Ser Ser Gln Glu Pro Tyr 
        195                 200                 205             


Phe Ser Tyr Ser Gly Ala Phe Lys Cys Leu Arg Asp Gly Ala Gly Asp 
    210                 215                 220                 


Val Ala Phe Ile Arg Glu Ser Thr Val Phe Glu Asp Leu Ser Asp Glu 
225                 230                 235                 240 


Ala Glu Arg Asp Glu Tyr Glu Leu Leu Cys Pro Asp Asn Thr Arg Lys 
                245                 250                 255     


Pro Val Asp Lys Phe Lys Asp Cys His Leu Ala Arg Val Pro Ser His 
            260                 265                 270         


Ala Val Val Ala Arg Ser Val Asn Gly Lys Glu Asp Ala Ile Trp Asn 
        275                 280                 285             


Leu Leu Arg Gln Ala Gln Glu Lys Phe Gly Lys Asp Lys Ser Pro Lys 
    290                 295                 300                 


Phe Gln Leu Phe Gly Ser Pro Ser Gly Gln Lys Asp Leu Leu Phe Lys 
305                 310                 315                 320 


Asp Ser Ala Ile Gly Phe Ser Arg Val Pro Pro Arg Ile Asp Ser Gly 
                325                 330                 335     


Leu Tyr Leu Gly Ser Gly Tyr Phe Thr Ala Ile Gln Asn Leu Arg Lys 
            340                 345                 350         


Ser Glu Glu Glu Val Ala Ala Arg Arg Ala Arg Val Val Trp Cys Ala 
        355                 360                 365             


Val Gly Glu Gln Glu Leu Arg Lys Cys Asn Gln Trp Ser Gly Leu Ser 
    370                 375                 380                 


Glu Gly Ser Val Thr Cys Ser Ser Ala Ser Thr Thr Glu Asp Cys Ile 
385                 390                 395                 400 


Ala Leu Lys Gly Glu Ala Asp Ala Met Ser Leu Asp Gly Gly Tyr Val 
                405                 410                 415     


Tyr Thr Ala Gly Lys Cys Gly Leu Val Pro Val Leu Ala Glu Asn Tyr 
            420                 425                 430         


Lys Ser Gln Gln Ser Ser Asp Pro Asp Pro Asn Cys Val Asp Arg Pro 
        435                 440                 445             


Val Glu Gly Tyr Leu Ala Val Ala Val Val Arg Arg Ser Asp Thr Ser 
    450                 455                 460                 


Leu Thr Trp Asn Ser Val Lys Gly Lys Lys Ser Cys His Thr Ala Val 
465                 470                 475                 480 


Asp Arg Thr Ala Gly Trp Asn Ile Pro Met Gly Leu Leu Phe Asn Gln 
                485                 490                 495     


Thr Gly Ser Cys Lys Phe Asp Glu Tyr Phe Ser Gln Ser Cys Ala Pro 
            500                 505                 510         


Gly Ser Asp Pro Arg Ser Asn Leu Cys Ala Leu Cys Ile Gly Asp Glu 
        515                 520                 525             


Gln Gly Glu Asn Lys Cys Val Pro Asn Ser Asn Glu Arg Tyr Tyr Gly 
    530                 535                 540                 


Tyr Thr Gly Ala Phe Arg Cys Leu Ala Glu Asn Ala Gly Asp Val Ala 
545                 550                 555                 560 


Phe Val Lys Asp Val Thr Val Leu Gln Asn Thr Asp Gly Asn Asn Asn 
                565                 570                 575     


Glu Ala Trp Ala Lys Asp Leu Lys Leu Ala Asp Phe Ala Leu Leu Cys 
            580                 585                 590         


Leu Asp Gly Lys Arg Lys Pro Val Thr Glu Ala Arg Ser Cys His Leu 
        595                 600                 605             


Ala Met Ala Pro Asn His Ala Val Val Ser Arg Met Asp Lys Val Glu 
    610                 615                 620                 


Arg Leu Lys Gln Val Leu Leu His Gln Gln Ala Lys Phe Gly Arg Asn 
625                 630                 635                 640 


Gly Ser Asp Cys Pro Asp Lys Phe Cys Leu Phe Gln Ser Glu Thr Lys 
                645                 650                 655     


Asn Leu Leu Phe Asn Asp Asn Thr Glu Cys Leu Ala Arg Leu His Gly 
            660                 665                 670         


Lys Thr Thr Tyr Glu Lys Tyr Leu Gly Pro Gln Tyr Val Ala Gly Ile 
        675                 680                 685             


Thr Asn Leu Lys Lys Cys Ser Thr Ser Pro Leu Leu Glu Ala Cys Glu 
    690                 695                 700                 


Phe Leu Arg Lys 
705             


<210>  8148
<211>  666
<212>  PRT
<213>  Homo Sapiens

<400>  8148

Met Arg Lys Val Arg Gly Pro Pro Val Ser Cys Ile Lys Arg Asp Ser 
1               5                   10                  15      


Pro Ile Gln Cys Ile Gln Ala Ile Ala Glu Asn Arg Ala Asp Ala Val 
            20                  25                  30          


Thr Leu Asp Gly Gly Phe Ile Tyr Glu Ala Gly Leu Ala Pro Tyr Lys 
        35                  40                  45              


Leu Arg Pro Val Ala Ala Glu Val Tyr Gly Thr Glu Arg Gln Pro Arg 
    50                  55                  60                  


Thr His Tyr Tyr Ala Val Ala Val Val Lys Lys Gly Gly Ser Phe Gln 
65                  70                  75                  80  


Leu Asn Glu Leu Gln Gly Leu Lys Ser Cys His Thr Gly Leu Arg Arg 
                85                  90                  95      


Thr Ala Gly Trp Asn Val Pro Ile Gly Thr Leu Arg Pro Phe Leu Asn 
            100                 105                 110         


Trp Thr Gly Pro Pro Glu Pro Ile Glu Ala Ala Val Ala Arg Phe Phe 
        115                 120                 125             


Ser Ala Ser Cys Val Pro Gly Ala Asp Lys Gly Gln Phe Pro Asn Leu 
    130                 135                 140                 


Cys Arg Leu Cys Ala Gly Thr Gly Glu Asn Lys Cys Ala Phe Ser Ser 
145                 150                 155                 160 


Gln Glu Pro Tyr Phe Ser Tyr Ser Gly Ala Phe Lys Cys Leu Arg Asp 
                165                 170                 175     


Gly Ala Gly Asp Val Ala Phe Ile Arg Glu Ser Thr Val Phe Glu Asp 
            180                 185                 190         


Leu Ser Asp Glu Ala Glu Arg Asp Glu Tyr Glu Leu Leu Cys Pro Asp 
        195                 200                 205             


Asn Thr Arg Lys Pro Val Asp Lys Phe Lys Asp Cys His Leu Ala Arg 
    210                 215                 220                 


Val Pro Ser His Ala Val Val Ala Arg Ser Val Asn Gly Lys Glu Asp 
225                 230                 235                 240 


Ala Ile Trp Asn Leu Leu Arg Gln Ala Gln Glu Lys Phe Gly Lys Asp 
                245                 250                 255     


Lys Ser Pro Lys Phe Gln Leu Phe Gly Ser Pro Ser Gly Gln Lys Asp 
            260                 265                 270         


Leu Leu Phe Lys Asp Ser Ala Ile Gly Phe Ser Arg Val Pro Pro Arg 
        275                 280                 285             


Ile Asp Ser Gly Leu Tyr Leu Gly Ser Gly Tyr Phe Thr Ala Ile Gln 
    290                 295                 300                 


Asn Leu Arg Lys Ser Glu Glu Glu Val Ala Ala Arg Arg Ala Arg Val 
305                 310                 315                 320 


Val Trp Cys Ala Val Gly Glu Gln Glu Leu Arg Lys Cys Asn Gln Trp 
                325                 330                 335     


Ser Gly Leu Ser Glu Gly Ser Val Thr Cys Ser Ser Ala Ser Thr Thr 
            340                 345                 350         


Glu Asp Cys Ile Ala Leu Val Leu Lys Gly Glu Ala Asp Ala Met Ser 
        355                 360                 365             


Leu Asp Gly Gly Tyr Val Tyr Thr Ala Gly Lys Cys Gly Leu Val Pro 
    370                 375                 380                 


Val Leu Ala Glu Asn Tyr Lys Ser Gln Gln Ser Ser Asp Pro Asp Pro 
385                 390                 395                 400 


Asn Cys Val Asp Arg Pro Val Glu Gly Tyr Leu Ala Val Ala Val Val 
                405                 410                 415     


Arg Arg Ser Asp Thr Ser Leu Thr Trp Asn Ser Val Lys Gly Lys Lys 
            420                 425                 430         


Ser Cys His Thr Ala Val Asp Arg Thr Ala Gly Trp Asn Ile Pro Met 
        435                 440                 445             


Gly Leu Leu Phe Asn Gln Thr Gly Ser Cys Lys Phe Asp Glu Tyr Phe 
    450                 455                 460                 


Ser Gln Ser Cys Ala Pro Gly Ser Asp Pro Arg Ser Asn Leu Cys Ala 
465                 470                 475                 480 


Leu Cys Ile Gly Asp Glu Gln Gly Glu Asn Lys Cys Val Pro Asn Ser 
                485                 490                 495     


Asn Glu Arg Tyr Tyr Gly Tyr Thr Gly Ala Phe Arg Cys Leu Ala Glu 
            500                 505                 510         


Asn Ala Gly Asp Val Ala Phe Val Lys Asp Val Thr Val Leu Gln Asn 
        515                 520                 525             


Thr Asp Gly Asn Asn Asn Glu Ala Trp Ala Lys Asp Leu Lys Leu Ala 
    530                 535                 540                 


Asp Phe Ala Leu Leu Cys Leu Asp Gly Lys Arg Lys Pro Val Thr Glu 
545                 550                 555                 560 


Ala Arg Ser Cys His Leu Ala Met Ala Pro Asn His Ala Val Val Ser 
                565                 570                 575     


Arg Met Asp Lys Val Glu Arg Leu Lys Gln Val Leu Leu His Gln Gln 
            580                 585                 590         


Ala Lys Phe Gly Arg Asn Gly Ser Asp Cys Pro Asp Lys Phe Cys Leu 
        595                 600                 605             


Phe Gln Ser Glu Thr Lys Asn Leu Leu Phe Asn Asp Asn Thr Glu Cys 
    610                 615                 620                 


Leu Ala Arg Leu His Gly Lys Thr Thr Tyr Glu Lys Tyr Leu Gly Pro 
625                 630                 635                 640 


Gln Tyr Val Ala Gly Ile Thr Asn Leu Lys Lys Cys Ser Thr Ser Pro 
                645                 650                 655     


Leu Leu Glu Ala Cys Glu Phe Leu Arg Lys 
            660                 665     


<210>  8149
<211>  864
<212>  PRT
<213>  Homo Sapiens

<400>  8149

Met Gly Cys Trp Gly Gln Leu Leu Val Trp Phe Gly Ala Ala Gly Ala 
1               5                   10                  15      


Ile Leu Cys Ser Ser Pro Gly Ser Gln Glu Thr Phe Leu Arg Ser Ser 
            20                  25                  30          


Pro Leu Pro Leu Ala Ser Pro Ser Pro Arg Asp Pro Lys Val Ser Ala 
        35                  40                  45              


Pro Pro Ser Ile Leu Glu Pro Ala Ser Pro Leu Asn Ser Pro Gly Thr 
    50                  55                  60                  


Glu Gly Ser Trp Leu Phe Ser Thr Cys Gly Ala Ser Gly Arg His Gly 
65                  70                  75                  80  


Pro Thr Gln Thr Gln Cys Asp Gly Ala Tyr Ala Gly Thr Ser Val Val 
                85                  90                  95      


Val Thr Val Gly Ala Ala Gly Gln Leu Arg Gly Val Gln Leu Trp Arg 
            100                 105                 110         


Val Pro Gly Pro Gly Gln Tyr Leu Ile Ser Ala Tyr Gly Ala Ala Gly 
        115                 120                 125             


Gly Lys Gly Ala Lys Asn His Leu Ser Arg Ala His Gly Val Phe Val 
    130                 135                 140                 


Ser Ala Ile Phe Ser Leu Gly Leu Gly Glu Ser Leu Tyr Ile Leu Val 
145                 150                 155                 160 


Gly Gln Gln Gly Glu Asp Ala Cys Pro Gly Gly Ser Pro Glu Ser Gln 
                165                 170                 175     


Leu Val Cys Leu Gly Glu Ser Arg Ala Val Glu Glu His Ala Ala Met 
            180                 185                 190         


Asp Gly Ser Glu Gly Val Pro Gly Ser Arg Arg Trp Ala Gly Gly Gly 
        195                 200                 205             


Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Arg Val Arg Ala Gly Glu 
    210                 215                 220                 


Leu Glu Pro Leu Leu Val Ala Ala Gly Gly Gly Gly Arg Ala Tyr Leu 
225                 230                 235                 240 


Arg Pro Arg Asp Arg Gly Arg Thr Gln Ala Ser Pro Glu Lys Leu Glu 
                245                 250                 255     


Asn Arg Ser Glu Ala Pro Gly Ser Gly Gly Arg Gly Gly Ala Ala Gly 
            260                 265                 270         


Gly Gly Gly Gly Trp Thr Ser Arg Ala Pro Ser Pro Gln Ala Gly Arg 
        275                 280                 285             


Ser Leu Gln Glu Gly Ala Glu Gly Gly Gln Gly Cys Ser Glu Ala Trp 
    290                 295                 300                 


Ala Thr Leu Gly Trp Ala Ala Ala Gly Gly Phe Gly Gly Gly Gly Gly 
305                 310                 315                 320 


Ala Cys Thr Ala Gly Gly Gly Gly Gly Gly Tyr Arg Gly Gly Asp Ala 
                325                 330                 335     


Ser Glu Thr Asp Asn Leu Trp Ala Asp Gly Glu Asp Gly Val Ser Phe 
            340                 345                 350         


Ile His Pro Ser Ser Glu Leu Phe Leu Gln Pro Leu Ala Val Thr Glu 
        355                 360                 365             


Asn His Gly Glu Val Glu Ile Arg Arg His Leu Asn Cys Ser His Cys 
    370                 375                 380                 


Pro Leu Arg Asp Cys Gln Trp Gln Ala Glu Leu Gln Leu Ala Glu Cys 
385                 390                 395                 400 


Leu Cys Pro Glu Gly Met Glu Leu Ala Val Asp Asn Val Thr Cys Met 
                405                 410                 415     


Asp Leu His Lys Pro Pro Gly Pro Leu Val Leu Met Val Ala Val Val 
            420                 425                 430         


Ala Thr Ser Thr Leu Ser Leu Leu Met Val Cys Gly Val Leu Ile Leu 
        435                 440                 445             


Val Lys Gln Lys Lys Trp Gln Gly Leu Gln Glu Met Arg Leu Pro Ser 
    450                 455                 460                 


Pro Glu Leu Glu Leu Ser Lys Leu Arg Thr Ser Ala Ile Arg Thr Ala 
465                 470                 475                 480 


Pro Asn Pro Tyr Tyr Cys Gln Val Gly Leu Gly Pro Ala Gln Ser Trp 
                485                 490                 495     


Pro Leu Pro Pro Gly Val Thr Glu Val Ser Pro Ala Asn Val Thr Leu 
            500                 505                 510         


Leu Arg Ala Leu Gly His Gly Ala Phe Gly Glu Val Tyr Glu Gly Leu 
        515                 520                 525             


Val Ile Gly Leu Pro Gly Asp Ser Ser Pro Leu Gln Val Ala Ile Lys 
    530                 535                 540                 


Thr Leu Pro Glu Leu Cys Ser Pro Gln Asp Glu Leu Asp Phe Leu Met 
545                 550                 555                 560 


Glu Ala Leu Ile Ile Ser Lys Phe Arg His Gln Asn Ile Val Arg Cys 
                565                 570                 575     


Val Gly Leu Ser Leu Arg Ala Thr Pro Arg Leu Ile Leu Leu Glu Leu 
            580                 585                 590         


Met Ser Gly Gly Asp Met Lys Ser Phe Leu Arg His Ser Arg Pro His 
        595                 600                 605             


Leu Gly Gln Pro Ser Pro Leu Val Met Arg Asp Leu Leu Gln Leu Ala 
    610                 615                 620                 


Gln Asp Ile Ala Gln Gly Cys His Tyr Leu Glu Glu Asn His Phe Ile 
625                 630                 635                 640 


His Arg Asp Ile Ala Ala Arg Asn Cys Leu Leu Ser Cys Ala Gly Pro 
                645                 650                 655     


Ser Arg Val Ala Lys Ile Gly Asp Phe Gly Met Ala Arg Asp Ile Tyr 
            660                 665                 670         


Arg Ala Ser Tyr Tyr Arg Arg Gly Asp Arg Ala Leu Leu Pro Val Lys 
        675                 680                 685             


Trp Met Pro Pro Glu Ala Phe Leu Glu Gly Ile Phe Thr Ser Lys Thr 
    690                 695                 700                 


Asp Ser Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Ser Leu Gly 
705                 710                 715                 720 


Tyr Met Pro Tyr Pro Gly Arg Thr Asn Gln Glu Val Leu Asp Phe Val 
                725                 730                 735     


Val Gly Gly Gly Arg Met Asp Pro Pro Arg Gly Cys Pro Gly Pro Val 
            740                 745                 750         


Tyr Arg Ile Met Thr Gln Cys Trp Gln His Glu Pro Glu Leu Arg Pro 
        755                 760                 765             


Ser Phe Ala Ser Ile Leu Glu Arg Leu Gln Tyr Cys Thr Gln Asp Pro 
    770                 775                 780                 


Asp Val Leu Asn Ser Leu Leu Pro Met Glu Leu Gly Pro Thr Pro Glu 
785                 790                 795                 800 


Glu Glu Gly Thr Ser Gly Leu Gly Asn Arg Ser Leu Glu Cys Leu Arg 
                805                 810                 815     


Pro Pro Gln Pro Gln Glu Leu Ser Pro Glu Lys Leu Lys Ser Trp Gly 
            820                 825                 830         


Gly Ser Pro Leu Gly Pro Trp Leu Ser Ser Gly Leu Lys Pro Leu Lys 
        835                 840                 845             


Ser Arg Gly Leu Gln Pro Gln Asn Leu Trp Asn Pro Thr Tyr Arg Ser 
    850                 855                 860                 


<210>  8150
<211>  803
<212>  PRT
<213>  Homo Sapiens

<400>  8150

Met Gly Cys Trp Gly Gln Leu Leu Val Trp Phe Gly Ala Ala Gly Ala 
1               5                   10                  15      


Ile Leu Cys Ser Ser Pro Gly Ser Gln Glu Thr Phe Leu Arg Ser Ser 
            20                  25                  30          


Pro Leu Pro Leu Ala Ser Pro Ser Pro Arg Asp Pro Lys Val Ser Ala 
        35                  40                  45              


Pro Pro Ser Ile Leu Glu Pro Ala Ser Pro Leu Asn Ser Pro Gly Thr 
    50                  55                  60                  


Glu Gly Ser Trp Leu Phe Ser Thr Cys Gly Ala Ser Gly Arg His Gly 
65                  70                  75                  80  


Pro Thr Gln Thr Gln Cys Asp Gly Ala Tyr Ala Gly Thr Ser Val Val 
                85                  90                  95      


Val Thr Val Gly Ala Ala Gly Gln Leu Arg Gly Val Gln Leu Trp Arg 
            100                 105                 110         


Val Pro Gly Pro Gly Gln Tyr Leu Ile Ser Ala Tyr Gly Ala Ala Gly 
        115                 120                 125             


Gly Lys Gly Ala Lys Asn His Leu Ser Arg Ala His Gly Val Phe Val 
    130                 135                 140                 


Ser Ala Ile Phe Ser Leu Gly Leu Gly Glu Ser Leu Tyr Ile Leu Val 
145                 150                 155                 160 


Gly Gln Gln Gly Glu Asp Ala Cys Pro Gly Gly Ser Pro Glu Ser Gln 
                165                 170                 175     


Leu Val Cys Leu Gly Glu Ser Arg Ala Val Glu Glu His Ala Ala Met 
            180                 185                 190         


Asp Gly Ser Glu Gly Val Pro Gly Ser Arg Arg Trp Ala Gly Gly Gly 
        195                 200                 205             


Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Arg Val Arg Ala Gly Glu 
    210                 215                 220                 


Leu Glu Pro Leu Leu Val Ala Ala Gly Gly Gly Gly Arg Ala Tyr Leu 
225                 230                 235                 240 


Arg Pro Arg Asp Arg Gly Arg Thr Gln Ala Ser Pro Glu Lys Leu Glu 
                245                 250                 255     


Asn Arg Ser Glu Ala Pro Gly Ser Gly Gly Arg Gly Gly Ala Ala Gly 
            260                 265                 270         


Gly Asp Ala Ser Glu Thr Asp Asn Leu Trp Ala Asp Gly Glu Asp Gly 
        275                 280                 285             


Val Ser Phe Ile His Pro Ser Ser Glu Leu Phe Leu Gln Pro Leu Ala 
    290                 295                 300                 


Val Thr Glu Asn His Gly Glu Val Glu Ile Arg Arg His Leu Asn Cys 
305                 310                 315                 320 


Ser His Cys Pro Leu Arg Asp Cys Gln Trp Gln Ala Glu Leu Gln Leu 
                325                 330                 335     


Ala Glu Cys Leu Cys Pro Glu Gly Met Glu Leu Ala Val Asp Asn Val 
            340                 345                 350         


Thr Cys Met Asp Leu His Lys Pro Pro Gly Pro Leu Val Leu Met Val 
        355                 360                 365             


Ala Val Val Ala Thr Ser Thr Leu Ser Leu Leu Met Val Cys Gly Val 
    370                 375                 380                 


Leu Ile Leu Val Lys Gln Lys Lys Trp Gln Gly Leu Gln Glu Met Arg 
385                 390                 395                 400 


Leu Pro Ser Pro Glu Leu Glu Leu Ser Lys Leu Arg Thr Ser Ala Ile 
                405                 410                 415     


Arg Thr Ala Pro Asn Pro Tyr Tyr Cys Gln Val Gly Leu Gly Pro Ala 
            420                 425                 430         


Gln Ser Trp Pro Leu Pro Pro Gly Val Thr Glu Val Ser Pro Ala Asn 
        435                 440                 445             


Val Thr Leu Leu Arg Ala Leu Gly His Gly Ala Phe Gly Glu Val Tyr 
    450                 455                 460                 


Glu Gly Leu Val Ile Gly Leu Pro Gly Asp Ser Ser Pro Leu Gln Val 
465                 470                 475                 480 


Ala Ile Lys Thr Leu Pro Glu Leu Cys Ser Pro Gln Asp Glu Leu Asp 
                485                 490                 495     


Phe Leu Met Glu Ala Leu Ile Ile Ser Lys Phe Arg His Gln Asn Ile 
            500                 505                 510         


Val Arg Cys Val Gly Leu Ser Leu Arg Ala Thr Pro Arg Leu Ile Leu 
        515                 520                 525             


Leu Glu Leu Met Ser Gly Gly Asp Met Lys Ser Phe Leu Arg His Ser 
    530                 535                 540                 


Arg Pro His Leu Gly Gln Pro Ser Pro Leu Val Met Arg Asp Leu Leu 
545                 550                 555                 560 


Gln Leu Ala Gln Asp Ile Ala Gln Gly Cys His Tyr Leu Glu Glu Asn 
                565                 570                 575     


His Phe Ile His Arg Asp Ile Ala Ala Arg Asn Cys Leu Leu Ser Cys 
            580                 585                 590         


Ala Gly Pro Ser Arg Val Ala Lys Ile Gly Asp Phe Gly Met Ala Arg 
        595                 600                 605             


Asp Ile Tyr Arg Ala Ser Tyr Tyr Arg Arg Gly Asp Arg Ala Leu Leu 
    610                 615                 620                 


Pro Val Lys Trp Met Pro Pro Glu Ala Phe Leu Glu Gly Ile Phe Thr 
625                 630                 635                 640 


Ser Lys Thr Asp Ser Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe 
                645                 650                 655     


Ser Leu Gly Tyr Met Pro Tyr Pro Gly Arg Thr Asn Gln Glu Val Leu 
            660                 665                 670         


Asp Phe Val Val Gly Gly Gly Arg Met Asp Pro Pro Arg Gly Cys Pro 
        675                 680                 685             


Gly Pro Val Tyr Arg Ile Met Thr Gln Cys Trp Gln His Glu Pro Glu 
    690                 695                 700                 


Leu Arg Pro Ser Phe Ala Ser Ile Leu Glu Arg Leu Gln Tyr Cys Thr 
705                 710                 715                 720 


Gln Asp Pro Asp Val Leu Asn Ser Leu Leu Pro Met Glu Leu Gly Pro 
                725                 730                 735     


Thr Pro Glu Glu Glu Gly Thr Ser Gly Leu Gly Asn Arg Ser Leu Glu 
            740                 745                 750         


Cys Leu Arg Pro Pro Gln Pro Gln Glu Leu Ser Pro Glu Lys Leu Lys 
        755                 760                 765             


Ser Trp Gly Gly Ser Pro Leu Gly Pro Trp Leu Ser Ser Gly Leu Lys 
    770                 775                 780                 


Pro Leu Lys Ser Arg Gly Leu Gln Pro Gln Asn Leu Trp Asn Pro Thr 
785                 790                 795                 800 


Tyr Arg Ser 
            


<210>  8151
<211>  734
<212>  PRT
<213>  Homo Sapiens

<400>  8151

Met Gly Cys Trp Gly Gln Leu Leu Val Trp Phe Gly Ala Ala Gly Ala 
1               5                   10                  15      


Ile Leu Cys Ser Ser Pro Gly Ser Gln Glu Thr Phe Leu Arg Ser Ser 
            20                  25                  30          


Pro Leu Pro Leu Ala Ser Pro Ser Pro Arg Asp Pro Lys Val Ser Ala 
        35                  40                  45              


Pro Pro Ser Ile Leu Glu Pro Ala Ser Pro Leu Asn Ser Pro Gly Thr 
    50                  55                  60                  


Glu Gly Ser Trp Leu Phe Ser Thr Cys Gly Ala Ser Gly Arg His Gly 
65                  70                  75                  80  


Pro Thr Gln Thr Gln Cys Asp Gly Ala Tyr Ala Gly Thr Ser Val Val 
                85                  90                  95      


Val Thr Val Gly Ala Ala Gly Gln Leu Arg Gly Val Gln Leu Trp Arg 
            100                 105                 110         


Val Pro Gly Pro Gly Gln Tyr Leu Ile Ser Ala Tyr Gly Ala Ala Gly 
        115                 120                 125             


Gly Lys Gly Ala Lys Asn His Leu Ser Arg Ala His Gly Val Phe Val 
    130                 135                 140                 


Ser Ala Ile Phe Ser Leu Gly Leu Gly Glu Ser Leu Tyr Ile Leu Val 
145                 150                 155                 160 


Gly Gln Gln Gly Glu Asp Ala Cys Pro Gly Gly Ser Pro Glu Ser Gln 
                165                 170                 175     


Leu Val Cys Leu Gly Glu Ser Arg Ala Val Glu Glu His Ala Ala Met 
            180                 185                 190         


Asp Gly Ser Glu Gly Val Pro Gly Ser Arg Arg Trp Ala Gly Gly Gly 
        195                 200                 205             


Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Arg Val Arg Ala Gly Glu 
    210                 215                 220                 


Leu Glu Pro Leu Leu Val Ala Ala Gly Gly Gly Gly Arg Ala Tyr Leu 
225                 230                 235                 240 


Arg Pro Arg Asp Arg Gly Arg Thr Gln Ala Ser Pro Glu Lys Leu Glu 
                245                 250                 255     


Asn Arg Ser Glu Ala Pro Gly Ser Gly Gly Arg Gly Gly Ala Ala Gly 
            260                 265                 270         


Gly Asp Ala Ser Glu Thr Asp Asn Leu Trp Ala Asp Gly Glu Asp Gly 
        275                 280                 285             


Val Ser Phe Ile His Pro Ser Ser Glu Leu Phe Leu Gln Pro Leu Ala 
    290                 295                 300                 


Val Thr Glu Asn His Gly Glu Val Glu Ile Arg Arg His Leu Asn Cys 
305                 310                 315                 320 


Ser His Cys Pro Leu Arg Asp Cys Gln Trp Gln Ala Glu Leu Gln Leu 
                325                 330                 335     


Ala Glu Cys Leu Cys Pro Glu Gly Met Glu Leu Ala Val Asp Asn Val 
            340                 345                 350         


Thr Cys Met Asp Leu His Lys Pro Pro Gly Pro Leu Val Leu Met Val 
        355                 360                 365             


Ala Val Val Ala Thr Ser Thr Leu Ser Leu Leu Met Val Cys Gly Val 
    370                 375                 380                 


Leu Ile Leu Gly Gly Ala Trp Pro Gly Pro Val Leu Ala Ser Ala Thr 
385                 390                 395                 400 


Arg Cys His Arg Gly Phe Pro Ser Gln Cys Tyr Ser Ala Gln Thr Leu 
                405                 410                 415     


Pro Glu Leu Cys Ser Pro Gln Asp Glu Leu Asp Phe Leu Met Glu Ala 
            420                 425                 430         


Leu Ile Ile Ser Lys Phe Arg His Gln Asn Ile Val Arg Cys Val Gly 
        435                 440                 445             


Leu Ser Leu Arg Ala Thr Pro Arg Leu Ile Leu Leu Glu Leu Met Ser 
    450                 455                 460                 


Gly Gly Asp Met Lys Ser Phe Leu Arg His Ser Arg Pro His Leu Gly 
465                 470                 475                 480 


Gln Pro Ser Pro Leu Val Met Arg Asp Leu Leu Gln Leu Ala Gln Asp 
                485                 490                 495     


Ile Ala Gln Gly Cys His Tyr Leu Glu Glu Asn His Phe Ile His Arg 
            500                 505                 510         


Asp Ile Ala Ala Arg Asn Cys Leu Leu Ser Cys Ala Gly Pro Ser Arg 
        515                 520                 525             


Val Ala Lys Ile Gly Asp Phe Gly Met Ala Arg Asp Ile Tyr Arg Ala 
    530                 535                 540                 


Ser Tyr Tyr Arg Arg Gly Asp Arg Ala Leu Leu Pro Val Lys Trp Met 
545                 550                 555                 560 


Pro Pro Glu Ala Phe Leu Glu Gly Ile Phe Thr Ser Lys Thr Asp Ser 
                565                 570                 575     


Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Ser Leu Gly Tyr Met 
            580                 585                 590         


Pro Tyr Pro Gly Arg Thr Asn Gln Glu Val Leu Asp Phe Val Val Gly 
        595                 600                 605             


Gly Gly Arg Met Asp Pro Pro Arg Gly Cys Pro Gly Pro Val Tyr Arg 
    610                 615                 620                 


Ile Met Thr Gln Cys Trp Gln His Glu Pro Glu Leu Arg Pro Ser Phe 
625                 630                 635                 640 


Ala Ser Ile Leu Glu Arg Leu Gln Tyr Cys Thr Gln Asp Pro Asp Val 
                645                 650                 655     


Leu Asn Ser Leu Leu Pro Met Glu Leu Gly Pro Thr Pro Glu Glu Glu 
            660                 665                 670         


Gly Thr Ser Gly Leu Gly Asn Arg Ser Leu Glu Cys Leu Arg Pro Pro 
        675                 680                 685             


Gln Pro Gln Glu Leu Ser Pro Glu Lys Leu Lys Ser Trp Gly Gly Ser 
    690                 695                 700                 


Pro Leu Gly Pro Trp Leu Ser Ser Gly Leu Lys Pro Leu Lys Ser Arg 
705                 710                 715                 720 


Gly Leu Gln Pro Gln Asn Leu Trp Asn Pro Thr Tyr Arg Ser 
                725                 730                 


<210>  8152
<211>  562
<212>  PRT
<213>  Homo Sapiens

<400>  8152

Met Gly Cys Trp Gly Gln Leu Leu Val Trp Phe Gly Ala Ala Gly Gly 
1               5                   10                  15      


Asp Ala Ser Glu Thr Asp Asn Leu Trp Ala Asp Gly Glu Asp Gly Val 
            20                  25                  30          


Ser Phe Ile His Pro Ser Ser Glu Leu Phe Leu Gln Pro Leu Ala Val 
        35                  40                  45              


Thr Glu Asn His Gly Glu Val Glu Ile Arg Arg His Leu Asn Cys Ser 
    50                  55                  60                  


His Cys Pro Leu Arg Asp Cys Gln Trp Gln Ala Glu Leu Gln Leu Ala 
65                  70                  75                  80  


Glu Cys Leu Cys Pro Glu Gly Met Glu Leu Ala Val Asp Asn Val Thr 
                85                  90                  95      


Cys Met Asp Leu His Lys Pro Pro Gly Pro Leu Val Leu Met Val Ala 
            100                 105                 110         


Val Val Ala Thr Ser Thr Leu Ser Leu Leu Met Val Cys Gly Val Leu 
        115                 120                 125             


Ile Leu Gly Thr Lys Arg Leu Ala Gly Thr Val Asp Ser Arg Leu Leu 
    130                 135                 140                 


Leu Ser Met Lys Gln Lys Lys Trp Gln Gly Leu Gln Glu Met Arg Leu 
145                 150                 155                 160 


Pro Ser Pro Glu Leu Glu Leu Ser Lys Leu Arg Thr Ser Ala Ile Arg 
                165                 170                 175     


Thr Ala Pro Asn Pro Tyr Tyr Cys Gln Val Gly Leu Gly Pro Ala Gln 
            180                 185                 190         


Ser Trp Pro Leu Pro Pro Gly Val Thr Glu Val Ser Pro Ala Asn Val 
        195                 200                 205             


Thr Leu Leu Arg Ala Leu Gly His Gly Ala Phe Gly Glu Val Tyr Glu 
    210                 215                 220                 


Gly Leu Val Ile Gly Leu Pro Gly Asp Ser Ser Pro Leu Gln Val Ala 
225                 230                 235                 240 


Ile Lys Thr Leu Pro Glu Leu Cys Ser Pro Gln Asp Glu Leu Asp Phe 
                245                 250                 255     


Leu Met Glu Ala Leu Ile Ile Ser Lys Phe Arg His Gln Asn Ile Val 
            260                 265                 270         


Arg Cys Val Gly Leu Ser Leu Arg Ala Thr Pro Arg Leu Ile Leu Leu 
        275                 280                 285             


Glu Leu Met Ser Gly Gly Asp Met Lys Ser Phe Leu Arg His Ser Arg 
    290                 295                 300                 


Pro His Leu Gly Gln Pro Ser Pro Leu Val Met Arg Asp Leu Leu Gln 
305                 310                 315                 320 


Leu Ala Gln Asp Ile Ala Gln Gly Cys His Tyr Leu Glu Glu Asn His 
                325                 330                 335     


Phe Ile His Arg Asp Ile Ala Ala Arg Asn Cys Leu Leu Ser Cys Ala 
            340                 345                 350         


Gly Pro Ser Arg Val Ala Lys Ile Gly Asp Phe Gly Met Ala Arg Asp 
        355                 360                 365             


Ile Tyr Arg Ala Ser Tyr Tyr Arg Arg Gly Asp Arg Ala Leu Leu Pro 
    370                 375                 380                 


Val Lys Trp Met Pro Pro Glu Ala Phe Leu Glu Gly Ile Phe Thr Ser 
385                 390                 395                 400 


Lys Thr Asp Ser Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Ser 
                405                 410                 415     


Leu Gly Tyr Met Pro Tyr Pro Gly Arg Thr Asn Gln Glu Val Leu Asp 
            420                 425                 430         


Phe Val Val Gly Gly Gly Arg Met Asp Pro Pro Arg Gly Cys Pro Gly 
        435                 440                 445             


Pro Val Tyr Arg Ile Met Thr Gln Cys Trp Gln His Glu Pro Glu Leu 
    450                 455                 460                 


Arg Pro Ser Phe Ala Ser Ile Leu Glu Arg Leu Gln Tyr Cys Thr Gln 
465                 470                 475                 480 


Asp Pro Asp Val Leu Asn Ser Leu Leu Pro Met Glu Leu Gly Pro Thr 
                485                 490                 495     


Pro Glu Glu Glu Gly Thr Ser Gly Leu Gly Asn Arg Ser Leu Glu Cys 
            500                 505                 510         


Leu Arg Pro Pro Gln Pro Gln Glu Leu Ser Pro Glu Lys Leu Lys Ser 
        515                 520                 525             


Trp Gly Gly Ser Pro Leu Gly Pro Trp Leu Ser Ser Gly Leu Lys Pro 
    530                 535                 540                 


Leu Lys Ser Arg Gly Leu Gln Pro Gln Asn Leu Trp Asn Pro Thr Tyr 
545                 550                 555                 560 


Arg Ser 
        


<210>  8153
<211>  338
<212>  PRT
<213>  Homo Sapiens

<400>  8153

Met Ser Leu Ser Ala Phe Thr Leu Phe Leu Ala Leu Ile Gly Gly Thr 
1               5                   10                  15      


Ser Gly Gln Tyr Tyr Asp Tyr Asp Phe Pro Leu Ser Ile Tyr Gly Gln 
            20                  25                  30          


Ser Ser Pro Asn Cys Ala Pro Glu Cys Asn Cys Pro Glu Ser Tyr Pro 
        35                  40                  45              


Ser Ala Met Tyr Cys Asp Glu Leu Lys Leu Lys Ser Val Pro Met Val 
    50                  55                  60                  


Pro Pro Gly Ile Lys Tyr Leu Tyr Leu Arg Asn Asn Gln Ile Asp His 
65                  70                  75                  80  


Ile Asp Glu Lys Ala Phe Glu Asn Val Thr Asp Leu Gln Trp Leu Ile 
                85                  90                  95      


Leu Asp His Asn Leu Leu Glu Asn Ser Lys Ile Lys Gly Arg Val Phe 
            100                 105                 110         


Ser Lys Leu Lys Gln Leu Lys Lys Leu His Ile Asn His Asn Asn Leu 
        115                 120                 125             


Thr Glu Ser Val Gly Pro Leu Pro Lys Ser Leu Glu Asp Leu Gln Leu 
    130                 135                 140                 


Thr His Asn Lys Ile Thr Lys Leu Gly Ser Phe Glu Gly Leu Val Asn 
145                 150                 155                 160 


Leu Thr Phe Ile His Leu Gln His Asn Arg Leu Lys Glu Asp Ala Val 
                165                 170                 175     


Ser Ala Ala Phe Lys Gly Leu Lys Ser Leu Glu Tyr Leu Asp Leu Ser 
            180                 185                 190         


Phe Asn Gln Ile Ala Arg Leu Pro Ser Gly Leu Pro Val Ser Leu Leu 
        195                 200                 205             


Thr Leu Tyr Leu Asp Asn Asn Lys Ile Ser Asn Ile Pro Asp Glu Tyr 
    210                 215                 220                 


Phe Lys Arg Phe Asn Ala Leu Gln Tyr Leu Arg Leu Ser His Asn Glu 
225                 230                 235                 240 


Leu Ala Asp Ser Gly Ile Pro Gly Asn Ser Phe Asn Val Ser Ser Leu 
                245                 250                 255     


Val Glu Leu Asp Leu Ser Tyr Asn Lys Leu Lys Asn Ile Pro Thr Val 
            260                 265                 270         


Asn Glu Asn Leu Glu Asn Tyr Tyr Leu Glu Val Asn Gln Leu Glu Lys 
        275                 280                 285             


Phe Asp Ile Lys Ser Phe Cys Lys Ile Leu Gly Pro Leu Ser Tyr Ser 
    290                 295                 300                 


Lys Ile Lys His Leu Arg Leu Asp Gly Asn Arg Ile Ser Glu Thr Ser 
305                 310                 315                 320 


Leu Pro Pro Asp Met Tyr Glu Cys Leu Arg Val Ala Asn Glu Val Thr 
                325                 330                 335     


Leu Asn 
        


<210>  8154
<211>  176
<212>  PRT
<213>  Homo Sapiens

<400>  8154

Met Lys Phe Ser Pro Ala His Tyr Leu Leu Pro Leu Leu Pro Ala Leu 
1               5                   10                  15      


Val Leu Ser Thr Arg Gln Asp Tyr Glu Glu Leu Glu Lys Gln Leu Lys 
            20                  25                  30          


Glu Val Phe Lys Glu Arg Ser Thr Ile Leu Arg Gln Leu Thr Lys Thr 
        35                  40                  45              


Ser Arg Glu Leu Asp Gly Ile Lys Val Asn Leu Gln Ser Leu Lys Asn 
    50                  55                  60                  


Asp Glu Gln Ser Ala Lys Thr Asp Val Gln Lys Leu Leu Glu Leu Gly 
65                  70                  75                  80  


Gln Lys Gln Arg Glu Glu Met Lys Ser Leu Gln Glu Ala Leu Gln Asn 
                85                  90                  95      


Gln Leu Lys Glu Thr Ser Glu Lys Ala Glu Lys His Gln Ala Thr Ile 
            100                 105                 110         


Asn Phe Leu Lys Thr Glu Val Glu Arg Lys Ser Lys Met Ile Arg Asp 
        115                 120                 125             


Leu Gln Asn Glu Ala Gln Gln Leu Thr Asp Leu Glu Gln Lys Leu Ala 
    130                 135                 140                 


Val Ala Lys Asn Glu Leu Glu Lys Ala Ala Leu Asp Arg Glu Ser Gln 
145                 150                 155                 160 


Met Lys Ala Met Lys Glu Thr Val Gln Leu Cys Leu Thr Ser Val Phe 
                165                 170                 175     


<210>  8155
<211>  346
<212>  PRT
<213>  Homo Sapiens

<400>  8155

Met Lys Phe Ser Pro Ala His Tyr Leu Leu Pro Leu Leu Pro Ala Leu 
1               5                   10                  15      


Val Leu Ser Thr Arg Gln Asp Tyr Glu Glu Leu Glu Lys Gln Leu Lys 
            20                  25                  30          


Glu Val Phe Lys Glu Arg Ser Thr Ile Leu Arg Gln Leu Thr Lys Thr 
        35                  40                  45              


Ser Arg Glu Leu Asp Gly Ile Lys Val Asn Leu Gln Ser Leu Lys Asn 
    50                  55                  60                  


Asp Glu Gln Ser Ala Lys Thr Asp Val Gln Lys Leu Leu Glu Leu Gly 
65                  70                  75                  80  


Gln Lys Gln Arg Glu Glu Met Lys Ser Leu Gln Glu Ala Leu Gln Asn 
                85                  90                  95      


Gln Leu Lys Glu Thr Ser Glu Lys Ala Glu Lys His Gln Ala Thr Ile 
            100                 105                 110         


Asn Phe Leu Lys Thr Glu Val Glu Arg Lys Ser Lys Met Ile Arg Asp 
        115                 120                 125             


Leu Gln Asn Glu Asn Lys Ser Leu Lys Asn Lys Leu Leu Ser Gly Asn 
    130                 135                 140                 


Lys Leu Cys Gly Ile His Ala Glu Glu Ser Lys Lys Ile Gln Ala Gln 
145                 150                 155                 160 


Leu Lys Glu Leu Arg Tyr Gly Lys Lys Asp Leu Leu Phe Lys Ala Gln 
                165                 170                 175     


Gln Leu Thr Asp Leu Glu Gln Lys Leu Ala Val Ala Lys Asn Glu Leu 
            180                 185                 190         


Glu Lys Ala Ala Leu Asp Arg Glu Ser Gln Met Lys Ala Met Lys Glu 
        195                 200                 205             


Thr Val Gln Leu Cys Leu Thr Ser Val Phe Arg Asp Gln Pro Pro Pro 
    210                 215                 220                 


Pro Leu Ser Leu Ile Thr Ser Asn Pro Thr Arg Met Leu Leu Pro Pro 
225                 230                 235                 240 


Arg Asn Ile Ala Ser Lys Leu Pro Asp Ala Ala Ala Lys Ser Lys Pro 
                245                 250                 255     


Gln Gln Ser Ala Ser Gly Asn Asn Glu Ser Ser Gln Val Glu Ser Thr 
            260                 265                 270         


Lys Glu Gly Asn Pro Ser Thr Thr Ala Cys Asp Ser Gln Asp Glu Gly 
        275                 280                 285             


Arg Pro Cys Ser Met Lys His Lys Glu Ser Pro Pro Ser Asn Ala Thr 
    290                 295                 300                 


Ala Glu Thr Glu Pro Ile Pro Gln Lys Leu Gln Met Pro Pro Cys Ser 
305                 310                 315                 320 


Glu Cys Glu Val Lys Lys Ala Pro Glu Lys Pro Leu Thr Ser Phe Glu 
                325                 330                 335     


Gly Met Ala Ala Arg Glu Glu Lys Ile Leu 
            340                 345     


<210>  8156
<211>  260
<212>  PRT
<213>  Homo Sapiens

<400>  8156

Met Lys Ser Leu Gln Glu Ala Leu Gln Asn Gln Leu Lys Glu Thr Ser 
1               5                   10                  15      


Glu Lys Ala Glu Lys His Gln Ala Thr Ile Asn Phe Leu Lys Thr Glu 
            20                  25                  30          


Val Glu Arg Lys Ser Lys Met Ile Arg Asp Leu Gln Asn Glu Asn Lys 
        35                  40                  45              


Ser Leu Lys Asn Lys Leu Leu Ser Gly Asn Lys Leu Cys Gly Ile His 
    50                  55                  60                  


Ala Glu Glu Ser Lys Lys Ile Gln Ala Gln Leu Lys Glu Leu Arg Tyr 
65                  70                  75                  80  


Gly Lys Lys Asp Leu Leu Phe Lys Ala Gln Gln Leu Thr Asp Leu Glu 
                85                  90                  95      


Gln Lys Leu Ala Val Ala Lys Asn Glu Leu Glu Lys Ala Ala Leu Asp 
            100                 105                 110         


Arg Glu Ser Gln Met Lys Ala Met Lys Glu Thr Val Gln Leu Cys Leu 
        115                 120                 125             


Thr Ser Val Phe Arg Asp Gln Pro Pro Pro Pro Leu Ser Leu Ile Thr 
    130                 135                 140                 


Ser Asn Pro Thr Arg Met Leu Leu Pro Pro Arg Asn Ile Ala Ser Lys 
145                 150                 155                 160 


Leu Pro Asp Ala Ala Ala Lys Ser Lys Pro Gln Gln Ser Ala Ser Gly 
                165                 170                 175     


Asn Asn Glu Ser Ser Gln Val Glu Ser Thr Lys Glu Gly Asn Pro Ser 
            180                 185                 190         


Thr Thr Ala Cys Asp Ser Gln Asp Glu Gly Arg Pro Cys Ser Met Lys 
        195                 200                 205             


His Lys Glu Ser Pro Pro Ser Asn Ala Thr Ala Glu Thr Glu Pro Ile 
    210                 215                 220                 


Pro Gln Lys Leu Gln Met Pro Pro Cys Ser Glu Cys Glu Val Lys Lys 
225                 230                 235                 240 


Ala Pro Glu Lys Pro Leu Thr Ser Phe Glu Gly Met Ala Ala Arg Glu 
                245                 250                 255     


Glu Lys Ile Leu 
            260 


<210>  8157
<211>  260
<212>  PRT
<213>  Homo Sapiens

<400>  8157

Met Lys Ser Leu Gln Glu Ala Leu Gln Asn Gln Leu Lys Glu Thr Ser 
1               5                   10                  15      


Glu Lys Ala Glu Lys His Gln Ala Thr Ile Asn Phe Leu Lys Thr Glu 
            20                  25                  30          


Val Glu Arg Lys Ser Lys Met Ile Arg Asp Leu Gln Asn Glu Asn Lys 
        35                  40                  45              


Ser Leu Lys Asn Lys Leu Leu Ser Gly Asn Lys Leu Cys Gly Ile His 
    50                  55                  60                  


Ala Glu Glu Ser Lys Lys Ile Gln Ala Gln Leu Lys Glu Leu Arg Tyr 
65                  70                  75                  80  


Gly Lys Lys Asp Leu Leu Phe Lys Ala Gln Gln Leu Thr Asp Leu Glu 
                85                  90                  95      


Gln Lys Leu Ala Val Ala Lys Asn Glu Leu Glu Lys Ala Ala Leu Asp 
            100                 105                 110         


Arg Glu Ser Gln Met Lys Ala Met Lys Glu Thr Val Gln Leu Cys Leu 
        115                 120                 125             


Thr Ser Val Phe Arg Asp Gln Pro Pro Pro Pro Leu Ser Leu Ile Thr 
    130                 135                 140                 


Ser Asn Pro Thr Arg Met Leu Leu Pro Pro Arg Asn Ile Ala Ser Lys 
145                 150                 155                 160 


Leu Pro Asp Ala Ala Ala Lys Ser Lys Pro Gln Gln Ser Ala Ser Gly 
                165                 170                 175     


Asn Asn Glu Ser Ser Gln Val Glu Ser Thr Lys Glu Gly Asn Pro Ser 
            180                 185                 190         


Thr Thr Ala Cys Asp Ser Gln Asp Glu Gly Arg Pro Cys Ser Met Lys 
        195                 200                 205             


His Lys Glu Ser Pro Pro Ser Asn Ala Thr Ala Glu Thr Glu Pro Ile 
    210                 215                 220                 


Pro Gln Lys Leu Gln Met Pro Pro Cys Ser Glu Cys Glu Val Lys Lys 
225                 230                 235                 240 


Ala Pro Glu Lys Pro Leu Thr Ser Phe Glu Gly Met Ala Ala Arg Glu 
                245                 250                 255     


Glu Lys Ile Leu 
            260 


<210>  8158
<211>  978
<212>  PRT
<213>  Homo Sapiens

<400>  8158

Met Gly Pro Pro Ser Ser Ser Gly Phe Tyr Val Ser Arg Ala Val Ala 
1               5                   10                  15      


Leu Leu Leu Ala Gly Leu Val Ala Ala Leu Leu Leu Ala Leu Ala Val 
            20                  25                  30          


Leu Ala Ala Leu Tyr Gly His Cys Glu Arg Val Pro Pro Ser Glu Leu 
        35                  40                  45              


Pro Gly Leu Arg Asp Leu Glu Ala Glu Ser Ser Pro Pro Leu Arg Gln 
    50                  55                  60                  


Lys Pro Thr Pro Thr Pro Lys Pro Ser Ser Ala Arg Glu Leu Ala Val 
65                  70                  75                  80  


Thr Thr Thr Pro Ser Asn Trp Arg Pro Pro Gly Pro Trp Asp Gln Leu 
                85                  90                  95      


Arg Leu Pro Pro Trp Leu Val Pro Leu His Tyr Asp Leu Glu Leu Trp 
            100                 105                 110         


Pro Gln Leu Arg Pro Asp Glu Leu Pro Ala Gly Ser Leu Pro Phe Thr 
        115                 120                 125             


Gly Arg Val Asn Ile Thr Val Arg Cys Thr Val Ala Thr Ser Arg Leu 
    130                 135                 140                 


Leu Leu His Ser Leu Phe Gln Asp Cys Glu Arg Ala Glu Val Arg Gly 
145                 150                 155                 160 


Pro Leu Ser Pro Asp Asp Val Trp Phe Ala Leu Asp Thr Glu Tyr Met 
                165                 170                 175     


Val Leu Glu Leu Ser Glu Pro Leu Lys Pro Gly Ser Ser Tyr Glu Leu 
            180                 185                 190         


Gln Leu Ser Phe Ser Gly Leu Val Lys Glu Asp Leu Arg Glu Gly Leu 
        195                 200                 205             


Phe Leu Asn Val Tyr Thr Asp Gln Gly Glu Arg Arg Ala Leu Leu Ala 
    210                 215                 220                 


Ser Gln Leu Glu Pro Thr Phe Ala Arg Tyr Val Phe Pro Cys Phe Asp 
225                 230                 235                 240 


Glu Pro Ala Leu Lys Ala Thr Phe Asn Ile Thr Met Ile His His Pro 
                245                 250                 255     


Ser Tyr Val Ala Leu Ser Asn Met Pro Lys Leu Gly Gln Ser Glu Lys 
            260                 265                 270         


Glu Asp Val Asn Gly Ser Lys Trp Thr Val Thr Thr Phe Ser Thr Thr 
        275                 280                 285             


Pro His Met Pro Thr Tyr Leu Val Ala Phe Val Ile Cys Asp Tyr Asp 
    290                 295                 300                 


His Val Asn Arg Thr Glu Arg Gly Lys Glu Ile Arg Ile Trp Ala Arg 
305                 310                 315                 320 


Lys Asp Ala Ile Ala Asn Gly Ser Ala Asp Phe Ala Leu Asn Ile Thr 
                325                 330                 335     


Gly Pro Ile Phe Ser Phe Leu Glu Asp Leu Phe Asn Ile Ser Tyr Ser 
            340                 345                 350         


Leu Pro Lys Thr Asp Ile Ile Ala Leu Pro Ser Phe Asp Asn His Ala 
        355                 360                 365             


Met Glu Asn Trp Gly Leu Met Ile Phe Asp Glu Ser Gly Leu Leu Leu 
    370                 375                 380                 


Glu Pro Lys Asp Gln Leu Thr Glu Lys Lys Thr Leu Ile Ser Tyr Val 
385                 390                 395                 400 


Val Ser His Glu Ile Gly His Gln Trp Phe Gly Asn Leu Val Thr Met 
                405                 410                 415     


Asn Trp Trp Asn Asn Ile Trp Leu Asn Glu Gly Phe Ala Ser Tyr Phe 
            420                 425                 430         


Glu Phe Glu Val Ile Asn Tyr Phe Asn Pro Lys Leu Pro Arg Asn Glu 
        435                 440                 445             


Ile Phe Phe Ser Asn Ile Leu His Asn Ile Leu Arg Glu Asp His Ala 
    450                 455                 460                 


Leu Val Thr Arg Ala Val Ala Met Lys Val Glu Asn Phe Lys Thr Ser 
465                 470                 475                 480 


Glu Ile Gln Glu Leu Phe Asp Ile Phe Thr Tyr Ser Lys Gly Ala Ser 
                485                 490                 495     


Met Ala Arg Met Leu Ser Cys Phe Leu Asn Glu His Leu Phe Val Ser 
            500                 505                 510         


Ala Leu Lys Ser Tyr Leu Lys Thr Phe Ser Tyr Ser Asn Ala Glu Gln 
        515                 520                 525             


Asp Asp Leu Trp Arg His Phe Gln Met Ala Ile Asp Asp Gln Ser Thr 
    530                 535                 540                 


Val Ile Leu Pro Ala Thr Ile Lys Asn Ile Met Asp Ser Trp Thr His 
545                 550                 555                 560 


Gln Ser Gly Phe Pro Val Ile Thr Leu Asn Val Ser Thr Gly Val Met 
                565                 570                 575     


Lys Gln Glu Pro Phe Tyr Leu Glu Asn Ile Lys Asn Arg Thr Leu Leu 
            580                 585                 590         


Thr Ser Asn Asp Thr Trp Ile Val Pro Ile Leu Trp Ile Lys Asn Gly 
        595                 600                 605             


Thr Thr Gln Pro Leu Val Trp Leu Asp Gln Ser Ser Lys Val Phe Pro 
    610                 615                 620                 


Glu Met Gln Val Ser Asp Ser Asp His Asp Trp Val Ile Leu Asn Leu 
625                 630                 635                 640 


Asn Met Thr Gly Tyr Tyr Arg Val Asn Tyr Asp Lys Leu Gly Trp Lys 
                645                 650                 655     


Lys Leu Asn Gln Gln Leu Glu Lys Asp Pro Lys Ala Ile Pro Val Ile 
            660                 665                 670         


His Arg Leu Gln Leu Ile Asp Asp Ala Phe Ser Leu Ser Lys Asn Asn 
        675                 680                 685             


Tyr Ile Glu Ile Glu Thr Ala Leu Glu Leu Thr Lys Tyr Leu Ala Glu 
    690                 695                 700                 


Glu Asp Glu Ile Ile Val Trp His Thr Val Leu Val Asn Leu Val Thr 
705                 710                 715                 720 


Arg Asp Leu Val Ser Glu Val Asn Ile Tyr Asp Ile Tyr Ser Leu Leu 
                725                 730                 735     


Lys Arg Tyr Leu Leu Lys Arg Leu Asn Leu Ile Trp Asn Ile Tyr Ser 
            740                 745                 750         


Thr Ile Ile Arg Glu Asn Val Leu Ala Leu Gln Asp Asp Tyr Leu Ala 
        755                 760                 765             


Leu Ile Ser Leu Glu Lys Leu Phe Val Thr Ala Cys Trp Leu Gly Leu 
    770                 775                 780                 


Glu Asp Cys Leu Gln Leu Ser Lys Glu Leu Phe Ala Lys Trp Val Asp 
785                 790                 795                 800 


His Pro Glu Asn Glu Ile Pro Tyr Pro Ile Lys Asp Val Val Leu Cys 
                805                 810                 815     


Tyr Gly Ile Ala Leu Gly Ser Asp Lys Glu Trp Asp Ile Leu Leu Asn 
            820                 825                 830         


Thr Tyr Thr Asn Thr Thr Asn Lys Glu Glu Lys Ile Gln Leu Ala Tyr 
        835                 840                 845             


Ala Met Ser Cys Ser Lys Asp Pro Trp Ile Leu Asn Arg Tyr Met Glu 
    850                 855                 860                 


Tyr Ala Ile Ser Thr Ser Pro Phe Thr Ser Asn Glu Thr Asn Ile Ile 
865                 870                 875                 880 


Glu Val Val Ala Ser Ser Glu Val Gly Arg Tyr Val Ala Lys Asp Phe 
                885                 890                 895     


Leu Val Asn Asn Trp Gln Ala Val Ser Lys Arg Tyr Gly Thr Gln Ser 
            900                 905                 910         


Leu Ile Asn Leu Ile Tyr Thr Ile Gly Arg Thr Val Thr Thr Asp Leu 
        915                 920                 925             


Gln Ile Val Glu Leu Gln Gln Phe Phe Ser Asn Met Leu Glu Glu His 
    930                 935                 940                 


Gln Arg Ile Arg Val His Ala Asn Leu Gln Thr Ile Lys Asn Glu Asn 
945                 950                 955                 960 


Leu Lys Asn Lys Lys Leu Ser Ala Arg Ile Ala Ala Trp Leu Arg Arg 
                965                 970                 975     


Asn Thr 
        


<210>  8159
<211>  990
<212>  PRT
<213>  Homo Sapiens

<400>  8159

Met Gly Pro Pro Ser Ser Ser Gly Phe Tyr Val Ser Arg Ala Val Ala 
1               5                   10                  15      


Leu Leu Leu Ala Gly Leu Val Ala Ala Leu Leu Leu Ala Leu Ala Val 
            20                  25                  30          


Leu Ala Ala Leu Tyr Gly His Cys Glu Arg Val Pro Pro Ser Glu Leu 
        35                  40                  45              


Pro Gly Leu Arg Asp Leu Glu Ala Glu Ser Ser Pro Pro Leu Arg Gln 
    50                  55                  60                  


Lys Pro Thr Pro Thr Pro Lys Pro Ser Ser Ala Arg Glu Leu Ala Val 
65                  70                  75                  80  


Thr Thr Thr Pro Ser Asn Trp Arg Pro Pro Gly Pro Trp Asp Gln Leu 
                85                  90                  95      


Arg Leu Pro Pro Trp Leu Val Pro Leu His Tyr Asp Leu Glu Leu Trp 
            100                 105                 110         


Pro Gln Leu Arg Pro Asp Glu Leu Pro Ala Gly Ser Leu Pro Phe Thr 
        115                 120                 125             


Gly Arg Val Asn Ile Thr Val Arg Cys Thr Val Ala Thr Ser Arg Leu 
    130                 135                 140                 


Leu Leu His Ser Leu Phe Gln Asp Cys Glu Arg Ala Glu Val Arg Gly 
145                 150                 155                 160 


Pro Leu Ser Pro Gly Thr Gly Asn Ala Thr Val Gly Arg Val Pro Val 
                165                 170                 175     


Asp Asp Val Trp Phe Ala Leu Asp Thr Glu Tyr Met Val Leu Glu Leu 
            180                 185                 190         


Ser Glu Pro Leu Lys Pro Gly Ser Ser Tyr Glu Leu Gln Leu Ser Phe 
        195                 200                 205             


Ser Gly Leu Val Lys Glu Asp Leu Arg Glu Gly Leu Phe Leu Asn Val 
    210                 215                 220                 


Tyr Thr Asp Gln Gly Glu Arg Arg Ala Leu Leu Ala Ser Gln Leu Glu 
225                 230                 235                 240 


Pro Thr Phe Ala Arg Tyr Val Phe Pro Cys Phe Asp Glu Pro Ala Leu 
                245                 250                 255     


Lys Ala Thr Phe Asn Ile Thr Met Ile His His Pro Ser Tyr Val Ala 
            260                 265                 270         


Leu Ser Asn Met Pro Lys Leu Gly Gln Ser Glu Lys Glu Asp Val Asn 
        275                 280                 285             


Gly Ser Lys Trp Thr Val Thr Thr Phe Ser Thr Thr Pro His Met Pro 
    290                 295                 300                 


Thr Tyr Leu Val Ala Phe Val Ile Cys Asp Tyr Asp His Val Asn Arg 
305                 310                 315                 320 


Thr Glu Arg Gly Lys Glu Ile Arg Ile Trp Ala Arg Lys Asp Ala Ile 
                325                 330                 335     


Ala Asn Gly Ser Ala Asp Phe Ala Leu Asn Ile Thr Gly Pro Ile Phe 
            340                 345                 350         


Ser Phe Leu Glu Asp Leu Phe Asn Ile Ser Tyr Ser Leu Pro Lys Thr 
        355                 360                 365             


Asp Ile Ile Ala Leu Pro Ser Phe Asp Asn His Ala Met Glu Asn Trp 
    370                 375                 380                 


Gly Leu Met Ile Phe Asp Glu Ser Gly Leu Leu Leu Glu Pro Lys Asp 
385                 390                 395                 400 


Gln Leu Thr Glu Lys Lys Thr Leu Ile Ser Tyr Val Val Ser His Glu 
                405                 410                 415     


Ile Gly His Gln Trp Phe Gly Asn Leu Val Thr Met Asn Trp Trp Asn 
            420                 425                 430         


Asn Ile Trp Leu Asn Glu Gly Phe Ala Ser Tyr Phe Glu Phe Glu Val 
        435                 440                 445             


Ile Asn Tyr Phe Asn Pro Lys Leu Pro Arg Asn Glu Ile Phe Phe Ser 
    450                 455                 460                 


Asn Ile Leu His Asn Ile Leu Arg Glu Asp His Ala Leu Val Thr Arg 
465                 470                 475                 480 


Ala Val Ala Met Lys Val Glu Asn Phe Lys Thr Ser Glu Ile Gln Glu 
                485                 490                 495     


Leu Phe Asp Ile Phe Thr Tyr Ser Lys Gly Ala Ser Met Ala Arg Met 
            500                 505                 510         


Leu Ser Cys Phe Leu Asn Glu His Leu Phe Val Ser Ala Leu Lys Ser 
        515                 520                 525             


Tyr Leu Lys Thr Phe Ser Tyr Ser Asn Ala Glu Gln Asp Asp Leu Trp 
    530                 535                 540                 


Arg His Phe Gln Met Ala Ile Asp Asp Gln Ser Thr Val Ile Leu Pro 
545                 550                 555                 560 


Ala Thr Ile Lys Asn Ile Met Asp Ser Trp Thr His Gln Ser Gly Phe 
                565                 570                 575     


Pro Val Ile Thr Leu Asn Val Ser Thr Gly Val Met Lys Gln Glu Pro 
            580                 585                 590         


Phe Tyr Leu Glu Asn Ile Lys Asn Arg Thr Leu Leu Thr Ser Asn Asp 
        595                 600                 605             


Thr Trp Ile Val Pro Ile Leu Trp Ile Lys Asn Gly Thr Thr Gln Pro 
    610                 615                 620                 


Leu Val Trp Leu Asp Gln Ser Ser Lys Val Phe Pro Glu Met Gln Val 
625                 630                 635                 640 


Ser Asp Ser Asp His Asp Trp Val Ile Leu Asn Leu Asn Met Thr Gly 
                645                 650                 655     


Tyr Tyr Arg Val Asn Tyr Asp Lys Leu Gly Trp Lys Lys Leu Asn Gln 
            660                 665                 670         


Gln Leu Glu Lys Asp Pro Lys Ala Ile Pro Val Ile His Arg Leu Gln 
        675                 680                 685             


Leu Ile Asp Asp Ala Phe Ser Leu Ser Lys Asn Asn Tyr Ile Glu Ile 
    690                 695                 700                 


Glu Thr Ala Leu Glu Leu Thr Lys Tyr Leu Ala Glu Glu Asp Glu Ile 
705                 710                 715                 720 


Ile Val Trp His Thr Val Leu Val Asn Leu Val Thr Arg Asp Leu Val 
                725                 730                 735     


Ser Glu Val Asn Ile Tyr Asp Ile Tyr Ser Leu Leu Lys Arg Tyr Leu 
            740                 745                 750         


Leu Lys Arg Leu Asn Leu Ile Trp Asn Ile Tyr Ser Thr Ile Ile Arg 
        755                 760                 765             


Glu Asn Val Leu Ala Leu Gln Asp Asp Tyr Leu Ala Leu Ile Ser Leu 
    770                 775                 780                 


Glu Lys Leu Phe Val Thr Ala Cys Trp Leu Gly Leu Glu Asp Cys Leu 
785                 790                 795                 800 


Gln Leu Ser Lys Glu Leu Phe Ala Lys Trp Val Asp His Pro Glu Asn 
                805                 810                 815     


Glu Ile Pro Tyr Pro Ile Lys Asp Val Val Leu Cys Tyr Gly Ile Ala 
            820                 825                 830         


Leu Gly Ser Asp Lys Glu Trp Asp Ile Leu Leu Asn Thr Tyr Thr Asn 
        835                 840                 845             


Thr Thr Asn Lys Glu Glu Lys Ile Gln Leu Ala Tyr Ala Met Ser Cys 
    850                 855                 860                 


Ser Lys Asp Pro Trp Ile Leu Asn Arg Tyr Met Glu Tyr Ala Ile Ser 
865                 870                 875                 880 


Thr Ser Pro Phe Thr Ser Asn Glu Thr Asn Ile Ile Glu Val Val Ala 
                885                 890                 895     


Ser Ser Glu Val Gly Arg Tyr Val Ala Lys Asp Phe Leu Val Asn Asn 
            900                 905                 910         


Trp Gln Ala Val Ser Lys Arg Tyr Gly Thr Gln Ser Leu Ile Asn Leu 
        915                 920                 925             


Ile Tyr Thr Ile Gly Arg Thr Val Thr Thr Asp Leu Gln Ile Val Glu 
    930                 935                 940                 


Leu Gln Gln Phe Phe Ser Asn Met Leu Glu Glu His Gln Arg Ile Arg 
945                 950                 955                 960 


Val His Ala Asn Leu Gln Thr Ile Lys Asn Glu Asn Leu Lys Asn Lys 
                965                 970                 975     


Lys Leu Ser Ala Arg Ile Ala Ala Trp Leu Arg Arg Asn Thr 
            980                 985                 990 


<210>  8160
<211>  701
<212>  PRT
<213>  Homo Sapiens

<400>  8160

Met Gly Pro Pro Ser Ser Ser Gly Phe Tyr Val Ser Arg Ala Val Ala 
1               5                   10                  15      


Leu Leu Leu Ala Gly Leu Val Ala Ala Leu Leu Leu Ala Leu Ala Val 
            20                  25                  30          


Leu Ala Ala Leu Tyr Gly His Cys Glu Arg Val Pro Pro Ser Glu Leu 
        35                  40                  45              


Pro Gly Leu Arg Asp Leu Glu Ala Glu Ser Ser Pro Pro Leu Arg Gln 
    50                  55                  60                  


Lys Pro Thr Pro Thr Pro Lys Pro Ser Ser Ala Arg Glu Leu Ala Val 
65                  70                  75                  80  


Thr Thr Thr Pro Ser Asn Trp Arg Pro Pro Gly Pro Trp Asp Gln Leu 
                85                  90                  95      


Arg Leu Pro Pro Trp Leu Val Pro Leu His Tyr Asp Leu Glu Leu Trp 
            100                 105                 110         


Pro Gln Leu Arg Pro Asp Glu Leu Pro Ala Gly Ser Leu Pro Phe Thr 
        115                 120                 125             


Gly Arg Val Asn Ile Thr Val Arg Cys Thr Val Ala Thr Ser Arg Leu 
    130                 135                 140                 


Leu Leu His Ser Leu Phe Gln Asp Cys Glu Arg Ala Glu Val Arg Gly 
145                 150                 155                 160 


Pro Leu Ser Pro Gly Thr Gly Asn Ala Thr Val Gly Arg Val Pro Val 
                165                 170                 175     


Asp Asp Val Trp Phe Ala Leu Asp Thr Glu Tyr Met Val Leu Glu Leu 
            180                 185                 190         


Ser Glu Pro Leu Lys Pro Gly Ser Ser Tyr Glu Leu Gln Leu Ser Phe 
        195                 200                 205             


Ser Gly Leu Val Lys Glu Asp Leu Arg Glu Gly Leu Phe Leu Asn Val 
    210                 215                 220                 


Tyr Thr Asp Gln Gly Glu Arg Arg Ala Leu Leu Ala Ser Gln Leu Glu 
225                 230                 235                 240 


Pro Thr Phe Ala Arg Tyr Val Phe Pro Cys Phe Asp Glu Pro Ala Leu 
                245                 250                 255     


Lys Ala Thr Phe Asn Ile Thr Met Ile His His Pro Ser Tyr Val Ala 
            260                 265                 270         


Leu Ser Asn Met Pro Lys Leu Gly Gln Ser Glu Lys Glu Asp Val Asn 
        275                 280                 285             


Gly Ser Lys Trp Thr Val Thr Thr Phe Ser Thr Thr Pro His Met Pro 
    290                 295                 300                 


Thr Tyr Leu Val Ala Phe Val Ile Cys Asp Tyr Asp His Val Asn Arg 
305                 310                 315                 320 


Thr Glu Arg Gly Lys Glu Ile Arg Ile Trp Ala Arg Lys Asp Ala Ile 
                325                 330                 335     


Ala Asn Gly Ser Ala Asp Phe Ala Leu Asn Ile Thr Gly Pro Ile Phe 
            340                 345                 350         


Ser Phe Leu Glu Asp Leu Phe Asn Ile Ser Tyr Ser Leu Pro Lys Thr 
        355                 360                 365             


Asp Ile Ile Ala Leu Pro Ser Phe Asp Asn His Ala Met Glu Asn Trp 
    370                 375                 380                 


Gly Leu Met Ile Phe Asp Glu Ser Gly Leu Leu Leu Glu Pro Lys Asp 
385                 390                 395                 400 


Gln Leu Thr Glu Lys Lys Thr Leu Ile Ser Tyr Val Val Ser His Glu 
                405                 410                 415     


Ile Gly His Gln Trp Phe Gly Asn Leu Val Thr Met Asn Trp Trp Asn 
            420                 425                 430         


Asn Ile Trp Leu Asn Glu Gly Phe Ala Ser Tyr Phe Glu Phe Glu Val 
        435                 440                 445             


Ile Asn Tyr Phe Asn Pro Lys Leu Pro Arg Asn Glu Ile Phe Phe Ser 
    450                 455                 460                 


Asn Ile Leu His Asn Ile Leu Arg Glu Asp His Ala Leu Val Thr Arg 
465                 470                 475                 480 


Ala Val Ala Met Lys Val Glu Asn Phe Lys Thr Ser Glu Ile Gln Glu 
                485                 490                 495     


Leu Phe Asp Ile Phe Thr Tyr Ser Lys Gly Ala Ser Met Ala Arg Met 
            500                 505                 510         


Leu Ser Cys Phe Leu Asn Glu His Leu Phe Val Ser Ala Leu Lys Ser 
        515                 520                 525             


Tyr Leu Lys Thr Phe Ser Tyr Ser Asn Ala Glu Gln Asp Asp Leu Trp 
    530                 535                 540                 


Arg His Phe Gln Met Ala Ile Asp Asp Gln Ser Thr Val Ile Leu Pro 
545                 550                 555                 560 


Ala Thr Ile Lys Asn Ile Met Asp Ser Trp Thr His Gln Ser Gly Phe 
                565                 570                 575     


Pro Val Ile Thr Leu Asn Val Ser Thr Gly Val Met Lys Gln Glu Pro 
            580                 585                 590         


Phe Tyr Leu Glu Asn Ile Lys Asn Arg Thr Leu Leu Thr Ser Asn Asp 
        595                 600                 605             


Thr Trp Ile Val Pro Ile Leu Trp Ile Lys Asn Gly Thr Thr Gln Pro 
    610                 615                 620                 


Leu Val Trp Leu Asp Gln Ser Ser Lys Val Phe Pro Glu Met Gln Val 
625                 630                 635                 640 


Ser Asp Ser Asp His Asp Trp Val Ile Leu Asn Leu Asn Met Thr Gly 
                645                 650                 655     


Tyr Tyr Arg Val Asn Tyr Asp Lys Leu Gly Trp Lys Lys Leu Asn Gln 
            660                 665                 670         


Gln Leu Glu Lys Asp Pro Lys Ala Ile Pro Val Ile His Arg Leu Gln 
        675                 680                 685             


Leu Ile Asp Asp Ala Phe Ser Leu Ser Lys Gly Thr Tyr 
    690                 695                 700     


<210>  8161
<211>  226
<212>  PRT
<213>  Homo Sapiens

<400>  8161

Met Lys Val Glu Asn Phe Lys Thr Ser Glu Ile Gln Glu Leu Phe Asp 
1               5                   10                  15      


Ile Phe Thr Tyr Ser Lys Gly Ala Ser Met Ala Arg Met Leu Ser Cys 
            20                  25                  30          


Phe Leu Asn Glu His Leu Phe Val Ser Ala Leu Lys Ser Tyr Leu Lys 
        35                  40                  45              


Thr Phe Ser Tyr Ser Asn Ala Glu Gln Asp Asp Leu Trp Arg His Phe 
    50                  55                  60                  


Gln Met Ala Ile Asp Asp Gln Ser Thr Val Ile Leu Pro Ala Thr Ile 
65                  70                  75                  80  


Lys Asn Ile Met Asp Ser Trp Thr His Gln Ser Gly Phe Pro Val Ile 
                85                  90                  95      


Thr Leu Asn Val Ser Thr Gly Val Met Lys Gln Glu Pro Phe Tyr Leu 
            100                 105                 110         


Glu Asn Ile Lys Asn Arg Thr Leu Leu Thr Ser Asn Asp Thr Trp Ile 
        115                 120                 125             


Val Pro Ile Leu Trp Ile Lys Asn Gly Thr Thr Gln Pro Leu Val Trp 
    130                 135                 140                 


Leu Asp Gln Ser Ser Lys Val Phe Pro Glu Met Gln Val Ser Asp Ser 
145                 150                 155                 160 


Asp His Asp Trp Val Ile Leu Asn Leu Asn Met Thr Gly Tyr Tyr Arg 
                165                 170                 175     


Val Asn Tyr Asp Lys Leu Gly Trp Lys Lys Leu Asn Gln Gln Leu Glu 
            180                 185                 190         


Lys Asp Pro Lys Ala Ile Pro Val Ile His Arg Leu Gln Leu Ile Asp 
        195                 200                 205             


Asp Ala Phe Ser Leu Ser Asn Leu Gln Asp Phe Gly His Leu Lys Val 
    210                 215                 220                 


Pro Asn 
225     


<210>  8162
<211>  198
<212>  PRT
<213>  Homo Sapiens

<400>  8162

Met Lys Val Glu Asn Phe Lys Thr Ser Glu Ile Gln Glu Leu Phe Asp 
1               5                   10                  15      


Ile Phe Thr Tyr Ser Lys Gly Ala Ser Met Ala Arg Met Leu Ser Cys 
            20                  25                  30          


Phe Leu Asn Glu His Leu Phe Val Ser Ala Leu Lys Ser Tyr Leu Lys 
        35                  40                  45              


Thr Phe Ser Tyr Ser Asn Ala Glu Gln Asp Asp Leu Trp Arg His Phe 
    50                  55                  60                  


Gln Met Ala Ile Asp Asp Gln Ser Thr Val Ile Leu Pro Ala Thr Ile 
65                  70                  75                  80  


Lys Asn Ile Met Asp Ser Trp Thr His Gln Ser Gly Phe Pro Val Ile 
                85                  90                  95      


Thr Leu Asn Val Ser Thr Gly Val Met Lys Gln Glu Pro Phe Tyr Leu 
            100                 105                 110         


Glu Asn Ile Lys Asn Arg Thr Leu Leu Thr Ser Asn Asp Thr Trp Ile 
        115                 120                 125             


Val Pro Ile Leu Trp Ile Lys Asn Gly Thr Thr Gln Pro Leu Val Trp 
    130                 135                 140                 


Leu Asp Gln Ser Ser Lys Val Phe Pro Glu Met Gln Val Ser Asp Ser 
145                 150                 155                 160 


Asp His Asp Trp Val Ile Leu Asn Leu Asn Met Thr Gly Tyr Tyr Arg 
                165                 170                 175     


Val Asn Tyr Asp Lys Leu Gly Trp Lys Lys Leu Asn Gln Gln Leu Glu 
            180                 185                 190         


Lys Asp Pro Lys Met Arg 
        195             


<210>  8163
<211>  198
<212>  PRT
<213>  Homo Sapiens

<400>  8163

Met Lys Val Glu Asn Phe Lys Thr Ser Glu Ile Gln Glu Leu Phe Asp 
1               5                   10                  15      


Ile Phe Thr Tyr Ser Lys Gly Ala Ser Met Ala Arg Met Leu Ser Cys 
            20                  25                  30          


Phe Leu Asn Glu His Leu Phe Val Ser Ala Leu Lys Ser Tyr Leu Lys 
        35                  40                  45              


Thr Phe Ser Tyr Ser Asn Ala Glu Gln Asp Asp Leu Trp Arg His Phe 
    50                  55                  60                  


Gln Met Ala Ile Asp Asp Gln Ser Thr Val Ile Leu Pro Ala Thr Ile 
65                  70                  75                  80  


Lys Asn Ile Met Asp Ser Trp Thr His Gln Ser Gly Phe Pro Val Ile 
                85                  90                  95      


Thr Leu Asn Val Ser Thr Gly Val Met Lys Gln Glu Pro Phe Tyr Leu 
            100                 105                 110         


Glu Asn Ile Lys Asn Arg Thr Leu Leu Thr Ser Asn Asp Thr Trp Ile 
        115                 120                 125             


Val Pro Ile Leu Trp Ile Lys Asn Gly Thr Thr Gln Pro Leu Val Trp 
    130                 135                 140                 


Leu Asp Gln Ser Ser Lys Val Phe Pro Glu Met Gln Val Ser Asp Ser 
145                 150                 155                 160 


Asp His Asp Trp Val Ile Leu Asn Leu Asn Met Thr Gly Tyr Tyr Arg 
                165                 170                 175     


Val Asn Tyr Asp Lys Leu Gly Trp Lys Lys Leu Asn Gln Gln Leu Glu 
            180                 185                 190         


Lys Asp Pro Lys Met Arg 
        195             


<210>  8164
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  8164

Met Lys Ile Phe Leu Pro Val Leu Leu Ala Ala Leu Leu Gly Val Glu 
1               5                   10                  15      


Arg Ala Ser Ser Leu Met Cys Phe Ser Cys Leu Asn Gln Lys Ser Asn 
            20                  25                  30          


Leu Tyr Cys Leu Lys Pro Thr Ile Cys Ser Asp Gln Asp Asn Tyr Cys 
        35                  40                  45              


Val Thr Val Ser Ala Ser Ala Gly Ile Ala Ser Phe Pro Met Gln Gly 
    50                  55                  60                  


Ile Ser 
65      


<210>  8165
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  8165

Met Lys Ile Phe Leu Pro Val Leu Leu Ala Ala Leu Leu Gly Val Glu 
1               5                   10                  15      


Arg Ala Ser Ser Leu Met Cys Phe Ser Cys Leu Asn Gln Lys Ser Asn 
            20                  25                  30          


Leu Tyr Cys Leu Lys Pro Thr Ile Cys Ser Asp Gln Asp Asn Tyr Cys 
        35                  40                  45              


Val Thr Val Ser Ala Ser Ala Gly Ile Ala Ser Phe Pro Met Gln Gly 
    50                  55                  60                  


Ile Ser 
65      


<210>  8166
<211>  73
<212>  PRT
<213>  Homo Sapiens

<400>  8166

Met Lys Ile Phe Leu Pro Val Leu Leu Ala Ala Leu Leu Gly Val Glu 
1               5                   10                  15      


Arg Ala Ser Ser Leu Met Cys Phe Ser Cys Leu Asn Gln Lys Ser Asn 
            20                  25                  30          


Leu Tyr Cys Leu Lys Pro Thr Ile Cys Ser Asp Gln Asp Asn Tyr Cys 
        35                  40                  45              


Val Thr Val Ser Ala Ser Ala Gly Ile Gly Glu Cys Gln Ala Ser Asp 
    50                  55                  60                  


Arg Ala Phe Leu Pro Trp Pro Ser Pro 
65                  70              


<210>  8167
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  8167

Met Lys Ile Phe Leu Pro Val Leu Leu Ala Ala Leu Leu Gly Val Glu 
1               5                   10                  15      


Arg Ala Ser Ser Leu Met Cys Phe Ser Cys Leu Asn Gln Lys Ser Asn 
            20                  25                  30          


Leu Tyr Cys Leu Lys Pro Thr Ile Cys Ser Asp Gln Asp Asn Tyr Cys 
        35                  40                  45              


Val Thr Val Ser Ala Ser Ala Gly Ile Gly Gly Phe Ala Gly Gly Thr 
    50                  55                  60                  


Asp Ser 
65      


<210>  8168
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  8168

Met Lys Ile Phe Leu Pro Val Leu Leu Ala Ala Leu Leu Gly Val Glu 
1               5                   10                  15      


Arg Ala Ser Ser Leu Met Cys Phe Ser Cys Leu Asn Gln Lys Ser Asn 
            20                  25                  30          


Leu Tyr Cys Leu Lys Pro Thr Ile Cys Ser Asp Gln Asp Asn Tyr Cys 
        35                  40                  45              


Val Thr Val Ser Ala Ser Ala Gly Ile Gly Asn Leu Val Thr Phe Gly 
    50                  55                  60                  


His Ser Leu Ser Lys Thr Cys Ser Pro Ala Cys Pro Ile Pro Glu Gly 
65                  70                  75                  80  


Val Asn Val Gly Val Ala Ser Met Gly Ile Ser Cys Cys Gln Ser Phe 
                85                  90                  95      


Leu Cys Asn Phe Ser Ala Ala Asp Gly Gly Leu Arg Ala Ser Val Thr 
            100                 105                 110         


Leu Leu Gly Ala Gly Leu Leu Leu Ser Leu Leu Pro Ala Leu Leu Arg 
        115                 120                 125             


Phe Gly Pro 
    130     


<210>  8169
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  8169

Met Lys Ile Phe Leu Pro Val Leu Leu Ala Ala Leu Leu Gly Val Glu 
1               5                   10                  15      


Arg Ala Ser Ser Leu Met Cys Phe Ser Cys Leu Asn Gln Lys Ser Asn 
            20                  25                  30          


Leu Tyr Cys Leu Lys Pro Thr Ile Cys Ser Asp Gln Asp Asn Tyr Cys 
        35                  40                  45              


Val Thr Val Ser Ala Ser Ala Gly Ile Gly Asn Leu Val Thr Phe Gly 
    50                  55                  60                  


His Ser Leu Ser Lys Thr Cys Ser Pro Ala Cys Pro Ile Pro Glu Gly 
65                  70                  75                  80  


Val Asn Val Gly Val Ala Ser Met Gly Ile Ser Cys Cys Gln Ser Phe 
                85                  90                  95      


Leu Cys Asn Phe Ser Ala Ala Asp Gly Gly Leu Arg Ala Ser Val Thr 
            100                 105                 110         


Leu Leu Gly Ala Gly Leu Leu Leu Ser Leu Leu Pro Ala Leu Leu Arg 
        115                 120                 125             


Phe Gly Pro 
    130     


<210>  8170
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  8170

Met Lys Ile Phe Leu Pro Val Leu Leu Ala Ala Leu Leu Gly Val Glu 
1               5                   10                  15      


Arg Ala Ser Ser Leu Met Cys Phe Ser Cys Leu Asn Gln Lys Ser Asn 
            20                  25                  30          


Leu Tyr Cys Leu Lys Pro Thr Ile Cys Ser Asp Gln Asp Asn Tyr Cys 
        35                  40                  45              


Val Thr Val Ser Ala Ser Ala Gly Ile Gly Asn Leu Val Thr Phe Gly 
    50                  55                  60                  


His Ser Leu Ser Lys Thr Cys Ser Pro Ala Cys Pro Ile Pro Glu Gly 
65                  70                  75                  80  


Val Asn Val Gly Val Ala Ser Met Gly Ile Ser Cys Cys Gln Ser Phe 
                85                  90                  95      


Leu Cys Asn Phe Ser Ala Ala Asp Gly Gly Leu Arg Ala Ser Val Thr 
            100                 105                 110         


Leu Leu Gly Ala Gly Leu Leu Leu Ser Leu Leu Pro Ala Leu Leu Arg 
        115                 120                 125             


Phe Gly Pro 
    130     


<210>  8171
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  8171

Met Lys Ile Phe Leu Pro Val Leu Leu Ala Ala Leu Leu Gly Val Glu 
1               5                   10                  15      


Arg Ala Ser Ser Leu Met Cys Phe Ser Cys Leu Asn Gln Lys Ser Asn 
            20                  25                  30          


Leu Tyr Cys Leu Lys Pro Thr Ile Cys Ser Asp Gln Asp Asn Tyr Cys 
        35                  40                  45              


Val Thr Val Ser Ala Ser Ala Gly Ile Gly Asn Leu Val Thr Phe Gly 
    50                  55                  60                  


His Ser Leu Ser Lys Thr Cys Ser Pro Ala Cys Pro Ile Pro Glu Gly 
65                  70                  75                  80  


Val Asn Val Gly Val Ala Ser Met Gly Ile Ser Cys Cys Gln Ser Phe 
                85                  90                  95      


Leu Cys Asn Phe Ser Ala Ala Asp Gly Gly Leu Arg Ala Ser Val Thr 
            100                 105                 110         


Leu Leu Gly Ala Gly Leu Leu Leu Ser Leu Leu Pro Ala Leu Leu Arg 
        115                 120                 125             


Phe Gly Pro 
    130     


<210>  8172
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  8172

Met Lys Ile Phe Leu Pro Val Leu Leu Ala Ala Leu Leu Gly Val Glu 
1               5                   10                  15      


Arg Ala Ser Ser Leu Met Cys Phe Ser Cys Leu Asn Gln Lys Ser Asn 
            20                  25                  30          


Leu Tyr Cys Leu Lys Pro Thr Ile Cys Ser Asp Gln Asp Asn Tyr Cys 
        35                  40                  45              


Val Thr Val Ser Ala Ser Ala Gly Ile Gly Asn Leu Val Thr Phe Gly 
    50                  55                  60                  


His Ser Leu Ser Lys Thr Cys Ser Pro Ala Cys Pro Ile Pro Glu Gly 
65                  70                  75                  80  


Val Asn Val Gly Val Ala Ser Met Gly Ile Ser Cys Cys Gln Ser Phe 
                85                  90                  95      


Leu Cys Asn Phe Ser Ala Ala Asp Gly Gly Leu Arg Ala Ser Val Thr 
            100                 105                 110         


Leu Leu Gly Ala Gly Leu Leu Leu Ser Leu Leu Pro Ala Leu Leu Arg 
        115                 120                 125             


Phe Gly Pro 
    130     


<210>  8173
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  8173

Met Lys Ile Phe Leu Pro Val Leu Leu Ala Ala Leu Leu Gly Val Glu 
1               5                   10                  15      


Arg Ala Ser Ser Leu Met Cys Phe Ser Cys Leu Asn Gln Lys Ser Asn 
            20                  25                  30          


Leu Tyr Cys Leu Lys Pro Thr Ile Cys Ser Asp Gln Asp Asn Tyr Cys 
        35                  40                  45              


Val Thr Val Ser Ala Ser Ala Gly Ile Gly Asn Leu Val Thr Phe Gly 
    50                  55                  60                  


His Ser Leu Ser Lys Thr Cys Ser Pro Ala Cys Pro Ile Pro Glu Gly 
65                  70                  75                  80  


Val Asn Val Gly Val Ala Ser Met Gly Ile Ser Cys Cys Gln Ser Phe 
                85                  90                  95      


Leu Cys Asn Phe Ser Ala Ala Asp Gly Gly Leu Arg Ala Ser Val Thr 
            100                 105                 110         


Leu Leu Gly Ala Gly Leu Leu Leu Ser Leu Leu Pro Ala Leu Leu Arg 
        115                 120                 125             


Phe Gly Pro 
    130     


<210>  8174
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  8174

Met Lys Ile Phe Leu Pro Val Leu Leu Ala Ala Leu Leu Gly Val Glu 
1               5                   10                  15      


Arg Ala Ser Ser Leu Met Cys Phe Ser Cys Leu Asn Gln Lys Ser Asn 
            20                  25                  30          


Leu Tyr Cys Leu Lys Pro Thr Ile Cys Ser Asp Gln Asp Asn Tyr Cys 
        35                  40                  45              


Val Thr Val Ser Ala Ser Ala Gly Ile Gly Asn Leu Val Thr Phe Gly 
    50                  55                  60                  


His Ser Leu Ser Lys Thr Cys Ser Pro Ala Cys Pro Ile Pro Glu Gly 
65                  70                  75                  80  


Val Asn Val Gly Val Ala Ser Met Gly Ile Ser Cys Cys Gln Ser Phe 
                85                  90                  95      


Leu Cys Asn Phe Ser Ala Ala Asp Gly Gly Leu Arg Ala Ser Val Thr 
            100                 105                 110         


Leu Leu Gly Ala Gly Leu Leu Leu Ser Leu Leu Pro Ala Leu Leu Arg 
        115                 120                 125             


Phe Gly Pro 
    130     


<210>  8175
<211>  41
<212>  PRT
<213>  Homo Sapiens

<400>  8175

Met Lys Ile Phe Leu Pro Val Leu Leu Ala Ala Leu Leu Gly Val Glu 
1               5                   10                  15      


Arg Glu Glu Gln Ser Val Leu Pro Glu Ala Asp His Leu Leu Arg Pro 
            20                  25                  30          


Gly Gln Leu Leu Arg Asp Cys Val Cys 
        35                  40      


<210>  8176
<211>  41
<212>  PRT
<213>  Homo Sapiens

<400>  8176

Met Lys Ile Phe Leu Pro Val Leu Leu Ala Ala Leu Leu Gly Val Glu 
1               5                   10                  15      


Arg Glu Glu Gln Ser Val Leu Pro Glu Ala Asp His Leu Leu Arg Pro 
            20                  25                  30          


Gly Gln Leu Leu Arg Asp Cys Val Cys 
        35                  40      


<210>  8177
<211>  147
<212>  PRT
<213>  Homo Sapiens

<400>  8177

Met Thr Ser Gly Ile Pro Gly Cys Gly Gly Ala Cys Val Leu Pro Ser 
1               5                   10                  15      


Arg Ala Pro Leu Arg Arg Arg Asp Pro Gln His Cys Ser Pro Thr Leu 
            20                  25                  30          


Ser Glu Ala Pro Leu Leu Arg Ala His Thr Gln Thr Arg Leu Leu Thr 
        35                  40                  45              


Arg Gly Leu Pro Thr Pro Asn Thr Thr Arg Thr Val Gln Val Ser Val 
    50                  55                  60                  


Thr Val Thr Pro Thr Trp Ser Pro Val Arg Pro Arg Gln Asp Arg Leu 
65                  70                  75                  80  


Leu Trp Phe Val Thr Ser Arg Gln Asp Gly His Pro Leu Gln Asn Glu 
                85                  90                  95      


Asp Leu Leu Ala Ser Ala Ala Gly Cys Pro Ser Gly Cys Gly Ala Ser 
            100                 105                 110         


Gln Leu Ala Asp Val Leu Leu Leu Leu Glu Pro Glu Glu Gln Ser Val 
        115                 120                 125             


Leu Pro Glu Ala Asp His Leu Leu Arg Pro Gly Gln Leu Leu Arg Asp 
    130                 135                 140                 


Cys Val Cys 
145         


<210>  8178
<211>  201
<212>  PRT
<213>  Homo Sapiens

<400>  8178

Met Lys Val His Met Leu Val Gly Val Leu Val Met Val Gly Phe Thr 
1               5                   10                  15      


Val Gly Lys Val Pro Val Pro Asp Ile Arg Thr Cys His Phe Cys Leu 
            20                  25                  30          


Val Glu Asp Pro Ser Val Gly Cys Ile Ser Gly Ser Glu Lys Cys Thr 
        35                  40                  45              


Ile Ser Ser Ser Ser Leu Cys Met Val Ile Thr Ile Tyr Tyr Asp Val 
    50                  55                  60                  


Lys Val Arg Phe Ile Val Arg Gly Cys Gly Gln Tyr Ile Ser Tyr Arg 
65                  70                  75                  80  


Cys Gln Glu Lys Arg Asn Thr Tyr Phe Ala Glu Tyr Trp Tyr Gln Ala 
                85                  90                  95      


Gln Cys Cys Gln Tyr Asp Tyr Cys Asn Ser Trp Ser Ser Pro Gln Leu 
            100                 105                 110         


Gln Ser Ser Leu Pro Glu Pro His Asp Arg Pro Leu Ala Leu Pro Leu 
        115                 120                 125             


Ser Asp Ser Gln Ile Gln Trp Phe Tyr Gln Ala Leu Asn Leu Ser Leu 
    130                 135                 140                 


Pro Leu Pro Asn Phe His Ala Gly Thr Glu Pro Asp Gly Leu Asp Pro 
145                 150                 155                 160 


Met Val Thr Leu Ser Leu Asn Leu Gly Leu Ser Phe Ala Glu Leu Arg 
                165                 170                 175     


Arg Met Tyr Leu Phe Leu Asn Ser Ser Gly Leu Leu Val Leu Pro Gln 
            180                 185                 190         


Ala Gly Leu Leu Thr Pro His Pro Ser 
        195                 200     


<210>  8179
<211>  146
<212>  PRT
<213>  Homo Sapiens

<400>  8179

Met Val Ile Thr Ile Tyr Tyr Asp Val Lys Val Arg Phe Ile Val Arg 
1               5                   10                  15      


Gly Cys Gly Gln Tyr Ile Ser Tyr Arg Cys Gln Glu Lys Arg Asn Thr 
            20                  25                  30          


Tyr Phe Ala Glu Tyr Trp Tyr Gln Ala Gln Cys Cys Gln Tyr Asp Tyr 
        35                  40                  45              


Cys Asn Ser Trp Ser Ser Pro Gln Leu Gln Ser Ser Leu Pro Glu Pro 
    50                  55                  60                  


His Asp Arg Pro Leu Ala Leu Pro Leu Ser Asp Ser Gln Ile Gln Trp 
65                  70                  75                  80  


Phe Tyr Gln Ala Leu Asn Leu Ser Leu Pro Leu Pro Asn Phe His Ala 
                85                  90                  95      


Gly Thr Glu Pro Asp Gly Leu Asp Pro Met Val Thr Leu Ser Leu Asn 
            100                 105                 110         


Leu Gly Leu Ser Phe Ala Glu Leu Arg Arg Met Tyr Leu Phe Leu Asn 
        115                 120                 125             


Ser Ser Gly Leu Leu Val Leu Pro Gln Ala Gly Leu Leu Thr Pro His 
    130                 135                 140                 


Pro Ser 
145     


<210>  8180
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  8180

Met Lys Pro Gln Phe Val Gly Ile Leu Leu Ser Ser Leu Leu Gly Ala 
1               5                   10                  15      


Ala Leu Gly Asn Arg Met Arg Cys Tyr Asn Cys Gly Gly Ser Pro Ser 
            20                  25                  30          


Ser Ser Cys Lys Glu Ala Val Thr Thr Cys Gly Glu Gly Arg Pro Gln 
        35                  40                  45              


Pro Gly Leu Glu Gln Ile Lys Leu Pro Gly Asn Pro Pro Val Thr Leu 
    50                  55                  60                  


Ile His Gln His Pro Ala Cys Val Ala Ala His His Cys Asn Gln Val 
65                  70                  75                  80  


Glu Thr Glu Ser Val Gly Asp Val Thr Tyr Pro Ala His Arg Asp Cys 
                85                  90                  95      


Tyr Leu Gly Asp Leu Cys Asn Ser Ala Val Ala Ser His Val Ala Pro 
            100                 105                 110         


Ala Gly Ile Leu Ala Ala Ala Ala Thr Ala Leu Thr Cys Leu Leu Pro 
        115                 120                 125             


Gly Leu Trp Ser Gly 
    130             


<210>  8181
<211>  174
<212>  PRT
<213>  Homo Sapiens

<400>  8181

Met Lys Pro Gln Phe Val Gly Ile Leu Leu Ser Ser Leu Leu Gly Ala 
1               5                   10                  15      


Ala Leu Gly Asn Arg Met Arg Cys Tyr Asn Cys Gly Gly Ser Pro Ser 
            20                  25                  30          


Ser Ser Cys Lys Glu Ala Val Thr Thr Cys Gly Glu Gly Arg Pro Gln 
        35                  40                  45              


Pro Gly Leu Glu Gln Ile Lys Leu Pro Gly Asn Arg Arg Cys Phe Leu 
    50                  55                  60                  


Arg Gly Leu Lys Ile Pro Leu Gly Ser Leu Lys Ser His Leu Leu Cys 
65                  70                  75                  80  


Pro Arg Arg Gln Val Leu Lys Pro Gly Val Gln His Pro Ser Phe Ile 
                85                  90                  95      


Leu Ser Leu Ser Pro Ser Asp Leu Asp Ser Pro Thr Ser Ser Leu Arg 
            100                 105                 110         


Arg Ser Pro Ser Leu Gln Ser Ser Gly Asp Arg Val Gly Gly Arg Arg 
        115                 120                 125             


Asp Leu Ser Ser Pro Gln Gly Leu Leu Pro Gly Arg Pro Val Gln Gln 
    130                 135                 140                 


Arg Arg Gly Lys Pro Cys Gly Pro Cys Arg His Phe Gly Cys Ser Ser 
145                 150                 155                 160 


Tyr Arg Pro Asp Leu Ser Leu Ala Arg Thr Val Glu Arg Ile 
                165                 170                 


<210>  8182
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  8182

Met Gly Thr Ser Ser Ile Phe Leu Cys Val Leu Phe Leu Cys Gly Ala 
1               5                   10                  15      


Leu Gly Leu Thr Met Ser Pro Ala Arg Gly Arg Leu Arg Cys Tyr Ile 
            20                  25                  30          


Cys Gly Phe Thr Lys Pro Cys His Pro Val Pro Thr Glu Cys Arg Asp 
        35                  40                  45              


Asp Glu Ala Cys Gly Ile Ser Ile Gly Thr Ser Asp Gln Ser Glu Ile 
    50                  55                  60                  


Thr Glu 
65      


<210>  8183
<211>  125
<212>  PRT
<213>  Homo Sapiens

<400>  8183

Met Gly Thr Ser Ser Ile Phe Leu Cys Val Leu Phe Leu Cys Gly Ala 
1               5                   10                  15      


Leu Gly Leu Thr Met Ser Pro Ala Arg Gly Arg Leu Arg Cys Tyr Ile 
            20                  25                  30          


Cys Gly Phe Thr Lys Pro Cys His Pro Val Pro Thr Glu Cys Arg Asp 
        35                  40                  45              


Asp Glu Ala Cys Gly Ile Ser Ile Gly Thr Ser Gly Lys Ser Cys Leu 
    50                  55                  60                  


Ser Arg Ala Gln Cys Pro Leu Pro Gly Tyr Ala Thr Tyr Trp Leu His 
65                  70                  75                  80  


Ser Tyr Thr Leu Trp His His Cys Cys Glu Gln Asp Leu Cys Asn Ile 
                85                  90                  95      


Ala Ala Ser Pro Gln Gln Leu Thr Ser Leu Leu Ala Ser Leu Pro Leu 
            100                 105                 110         


Phe Val Ala Ser Phe Ala Gly Arg Gly His Leu Leu His 
        115                 120                 125 


<210>  8184
<211>  100
<212>  PRT
<213>  Homo Sapiens

<400>  8184

Met Gly Thr Ser Ser Ile Phe Leu Cys Val Leu Phe Leu Cys Gly Ala 
1               5                   10                  15      


Leu Gly Leu Thr Met Ser Pro Ala Arg Gly Arg Leu Arg Cys Tyr Ile 
            20                  25                  30          


Cys Gly Phe Thr Lys Pro Cys His Pro Val Pro Thr Glu Cys Arg Asp 
        35                  40                  45              


Asp Glu Ala Cys Gly Ile Ser Ile Gly Thr Ser Gly Arg Thr Leu Val 
    50                  55                  60                  


Gln Trp Pro Phe Ser Arg Arg Leu Pro Thr Ser Ile His Pro Ala Phe 
65                  70                  75                  80  


Pro Val Ala Pro Ala Ser Ala Cys Leu Phe His Pro Thr Asp Gln Ser 
                85                  90                  95      


Glu Ile Thr Glu 
            100 


<210>  8185
<211>  88
<212>  PRT
<213>  Homo Sapiens

<400>  8185

Met Leu Gln Leu Tyr Lys Ser Arg Asp Leu Gly Val Gln Ile Thr Ser 
1               5                   10                  15      


Pro Arg Phe Leu Ser Leu Cys Leu Ala Met Gly Thr Ser Ser Ile Phe 
            20                  25                  30          


Leu Cys Val Leu Phe Leu Cys Gly Ala Leu Gly Leu Thr Met Ser Pro 
        35                  40                  45              


Ala Arg Gly Arg Leu Arg Cys Tyr Ile Cys Gly Phe Thr Lys Pro Cys 
    50                  55                  60                  


His Pro Val Pro Thr Glu Cys Arg Asp Asp Glu Ala Cys Gly Ile Ser 
65                  70                  75                  80  


Ile Gly Thr Ser Asp Ala His Cys 
                85              


<210>  8186
<211>  161
<212>  PRT
<213>  Homo Sapiens

<400>  8186

Met Leu Ala Pro Gln Arg Thr Arg Ala Pro Ser Pro Arg Ala Ala Pro 
1               5                   10                  15      


Arg Pro Thr Arg Ser Met Leu Pro Ala Ala Met Lys Gly Leu Gly Leu 
            20                  25                  30          


Ala Leu Leu Ala Val Leu Leu Cys Ser Ala Pro Ala His Gly Leu Trp 
        35                  40                  45              


Cys Gln Asp Cys Thr Leu Thr Thr Asn Ser Ser His Cys Thr Pro Lys 
    50                  55                  60                  


Gln Cys Gln Pro Ser Asp Thr Val Cys Ala Ser Val Arg Ile Thr Asp 
65                  70                  75                  80  


Pro Ser Ser Ser Arg Lys Asp His Ser Val Asn Lys Met Cys Ala Ser 
                85                  90                  95      


Ser Cys Asp Phe Val Lys Arg His Phe Phe Ser Asp Tyr Leu Met Gly 
            100                 105                 110         


Phe Ile Asn Ser Gly Ile Leu Lys Val Asp Val Asp Cys Cys Glu Lys 
        115                 120                 125             


Asp Leu Cys Asn Gly Ala Ala Gly Ala Gly His Ser Pro Trp Ala Leu 
    130                 135                 140                 


Ala Gly Gly Leu Leu Leu Ser Leu Gly Pro Ala Leu Leu Trp Ala Gly 
145                 150                 155                 160 


Pro 
    


<210>  8187
<211>  161
<212>  PRT
<213>  Homo Sapiens

<400>  8187

Met Leu Ala Pro Gln Arg Thr Arg Ala Pro Ser Pro Arg Ala Ala Pro 
1               5                   10                  15      


Arg Pro Thr Arg Ser Met Leu Pro Ala Ala Met Lys Gly Leu Gly Leu 
            20                  25                  30          


Ala Leu Leu Ala Val Leu Leu Cys Ser Ala Pro Ala His Gly Leu Trp 
        35                  40                  45              


Cys Gln Asp Cys Thr Leu Thr Thr Asn Ser Ser His Cys Thr Pro Lys 
    50                  55                  60                  


Gln Cys Gln Pro Ser Asp Thr Val Cys Ala Ser Val Arg Ile Thr Asp 
65                  70                  75                  80  


Pro Ser Ser Ser Arg Lys Asp His Ser Val Asn Lys Met Cys Ala Ser 
                85                  90                  95      


Ser Cys Asp Phe Val Lys Arg His Phe Phe Ser Asp Tyr Leu Met Gly 
            100                 105                 110         


Phe Ile Asn Ser Gly Ile Leu Lys Val Asp Val Asp Cys Cys Glu Lys 
        115                 120                 125             


Asp Leu Cys Asn Gly Ala Ala Gly Ala Gly His Ser Pro Trp Ala Leu 
    130                 135                 140                 


Ala Gly Gly Leu Leu Leu Ser Leu Gly Pro Ala Leu Leu Trp Ala Gly 
145                 150                 155                 160 


Pro 
    


<210>  8188
<211>  140
<212>  PRT
<213>  Homo Sapiens

<400>  8188

Met Leu Pro Ala Ala Met Lys Gly Leu Gly Leu Ala Leu Leu Ala Val 
1               5                   10                  15      


Leu Leu Cys Ser Ala Pro Ala His Gly Leu Trp Cys Gln Asp Cys Thr 
            20                  25                  30          


Leu Thr Thr Asn Ser Ser His Cys Thr Pro Lys Gln Cys Gln Pro Ser 
        35                  40                  45              


Asp Thr Val Cys Ala Ser Val Arg Ile Thr Asp Pro Ser Ser Ser Arg 
    50                  55                  60                  


Lys Asp His Ser Val Asn Lys Met Cys Ala Ser Ser Cys Asp Phe Val 
65                  70                  75                  80  


Lys Arg His Phe Phe Ser Asp Tyr Leu Met Gly Phe Ile Asn Ser Gly 
                85                  90                  95      


Ile Leu Lys Val Asp Val Asp Cys Cys Glu Lys Asp Leu Cys Asn Gly 
            100                 105                 110         


Ala Ala Gly Ala Gly His Ser Pro Trp Ala Leu Ala Gly Gly Leu Leu 
        115                 120                 125             


Leu Ser Leu Gly Pro Ala Leu Leu Trp Ala Gly Pro 
    130                 135                 140 


<210>  8189
<211>  140
<212>  PRT
<213>  Homo Sapiens

<400>  8189

Met Leu Pro Ala Ala Met Lys Gly Leu Gly Leu Ala Leu Leu Ala Val 
1               5                   10                  15      


Leu Leu Cys Ser Ala Pro Ala His Gly Leu Trp Cys Gln Asp Cys Thr 
            20                  25                  30          


Leu Thr Thr Asn Ser Ser His Cys Thr Pro Lys Gln Cys Gln Pro Ser 
        35                  40                  45              


Asp Thr Val Cys Ala Ser Val Arg Ile Thr Asp Pro Ser Ser Ser Arg 
    50                  55                  60                  


Lys Asp His Ser Val Asn Lys Met Cys Ala Ser Ser Cys Asp Phe Val 
65                  70                  75                  80  


Lys Arg His Phe Phe Ser Asp Tyr Leu Met Gly Phe Ile Asn Ser Gly 
                85                  90                  95      


Ile Leu Lys Val Asp Val Asp Cys Cys Glu Lys Asp Leu Cys Asn Gly 
            100                 105                 110         


Ala Ala Gly Ala Gly His Ser Pro Trp Ala Leu Ala Gly Gly Leu Leu 
        115                 120                 125             


Leu Ser Leu Gly Pro Ala Leu Leu Trp Ala Gly Pro 
    130                 135                 140 


<210>  8190
<211>  165
<212>  PRT
<213>  Homo Sapiens

<400>  8190

Met Ala Leu Leu Ala Leu Leu Leu Val Val Ala Leu Pro Arg Val Trp 
1               5                   10                  15      


Thr Asp Ala Asn Leu Thr Ala Arg Gln Arg Asp Pro Glu Asp Ser Gln 
            20                  25                  30          


Arg Thr Asp Glu Gly Asp Asn Arg Val Trp Cys His Val Cys Glu Arg 
        35                  40                  45              


Glu Asn Thr Phe Glu Cys Gln Asn Pro Arg Arg Cys Lys Trp Thr Glu 
    50                  55                  60                  


Pro Tyr Cys Val Ile Ala Ala Val Lys Ile Phe Pro Arg Phe Phe Met 
65                  70                  75                  80  


Val Ala Lys Gln Cys Ser Ala Gly Cys Ala Ala Met Glu Arg Pro Lys 
                85                  90                  95      


Pro Glu Glu Lys Arg Phe Leu Leu Glu Glu Pro Met Pro Phe Phe Tyr 
            100                 105                 110         


Leu Lys Cys Cys Lys Ile Arg Tyr Cys Asn Leu Glu Gly Pro Pro Ile 
        115                 120                 125             


Asn Ser Ser Val Phe Lys Glu Tyr Ala Gly Ser Met Gly Glu Ser Cys 
    130                 135                 140                 


Gly Gly Leu Trp Leu Ala Ile Leu Leu Leu Leu Ala Ser Ile Ala Ala 
145                 150                 155                 160 


Gly Leu Ser Leu Ser 
                165 


<210>  8191
<211>  100
<212>  PRT
<213>  Homo Sapiens

<400>  8191

Met Ala Leu Leu Ala Leu Leu Leu Val Val Ala Leu Pro Arg Val Trp 
1               5                   10                  15      


Thr Asp Ala Asn Leu Thr Ala Arg Gln Arg Asp Pro Glu Asp Ser Gln 
            20                  25                  30          


Arg Thr Asp Glu Gly Asp Asn Arg Val Trp Cys His Val Cys Glu Arg 
        35                  40                  45              


Glu Asn Thr Phe Glu Cys Gln Asn Pro Arg Arg Cys Lys Trp Thr Glu 
    50                  55                  60                  


Pro Tyr Cys Val Ile Ala Ala Val Arg Arg Ser Ser Gly Leu Val Asn 
65                  70                  75                  80  


Ser Asp Ser Ala Gln Gln Ser Leu Ser Ser Pro Ser Val Ser Thr Lys 
                85                  90                  95      


Leu Val Gly Cys 
            100 


<210>  8192
<211>  85
<212>  PRT
<213>  Homo Sapiens

<400>  8192

Met Ala Leu Leu Ala Leu Leu Leu Val Val Ala Leu Pro Arg Val Trp 
1               5                   10                  15      


Thr Asp Ala Asn Leu Thr Ala Arg Gln Arg Asp Pro Glu Asp Ser Gln 
            20                  25                  30          


Arg Thr Asp Glu Gly Asp Asn Arg Val Trp Cys His Val Cys Glu Arg 
        35                  40                  45              


Glu Asn Thr Phe Glu Cys Gln Asn Pro Arg Arg Cys Lys Trp Thr Glu 
    50                  55                  60                  


Pro Tyr Cys Val Ile Ala Ala Val Ser Glu Tyr Leu Arg Ser Cys Trp 
65                  70                  75                  80  


Gly Pro Lys Gly Arg 
                85  


<210>  8193
<211>  105
<212>  PRT
<213>  Homo Sapiens

<400>  8193

Met Ala Leu Leu Ala Leu Leu Leu Val Val Ala Leu Pro Arg Val Trp 
1               5                   10                  15      


Thr Asp Ala Asn Leu Thr Ala Arg Gln Arg Asp Pro Glu Asp Ser Gln 
            20                  25                  30          


Arg Thr Asp Glu Gly Asp Asn Arg Val Trp Cys His Val Cys Glu Arg 
        35                  40                  45              


Glu Asn Thr Phe Glu Cys Gln Asn Pro Arg Arg Cys Lys Trp Thr Glu 
    50                  55                  60                  


Pro Tyr Cys Val Ile Ala Ala Val Thr Val Leu Arg Trp Leu Cys Ser 
65                  70                  75                  80  


Asp Gly Glu Thr Gln Ala Arg Gly Glu Ala Val Ser Pro Gly Arg Ala 
                85                  90                  95      


His Ala Leu Leu Leu Pro Gln Val Leu 
            100                 105 


<210>  8194
<211>  138
<212>  PRT
<213>  Homo Sapiens

<400>  8194

Met Glu Arg Leu Val Leu Thr Leu Cys Thr Leu Pro Leu Ala Val Ala 
1               5                   10                  15      


Ser Ala Gly Cys Ala Thr Thr Pro Ala Arg Asn Leu Ser Cys Tyr Gln 
            20                  25                  30          


Cys Phe Lys Val Ser Ser Trp Thr Glu Cys Pro Pro Thr Trp Cys Ser 
        35                  40                  45              


Pro Leu Asp Gln Val Cys Ile Ser Asn Glu Val Val Val Ser Phe Lys 
    50                  55                  60                  


Trp Ser Val Arg Val Leu Leu Ser Lys Arg Cys Ala Pro Arg Cys Pro 
65                  70                  75                  80  


Asn Asp Asn Met Lys Phe Glu Trp Ser Pro Ala Pro Met Val Gln Gly 
                85                  90                  95      


Val Ile Thr Arg Arg Cys Cys Ser Trp Ala Leu Cys Asn Arg Ala Leu 
            100                 105                 110         


Thr Pro Gln Glu Gly Arg Trp Ala Leu Arg Gly Gly Leu Leu Leu Gln 
        115                 120                 125             


Val Gly Leu Ser Leu Leu Arg Ala Leu Leu 
    130                 135             


<210>  8195
<211>  162
<212>  PRT
<213>  Homo Sapiens

<400>  8195

Met Lys Gly Phe Thr Ala Thr Leu Phe Leu Trp Thr Leu Ile Phe Pro 
1               5                   10                  15      


Ser Cys Ser Gly Gly Gly Gly Gly Lys Ala Trp Pro Thr His Val Val 
            20                  25                  30          


Cys Ser Asp Ser Gly Leu Glu Val Leu Tyr Gln Ser Cys Asp Pro Leu 
        35                  40                  45              


Gln Asp Phe Gly Phe Ser Val Glu Lys Cys Ser Lys Gln Leu Lys Ser 
    50                  55                  60                  


Asn Ile Asn Ile Arg Phe Gly Ile Ile Leu Arg Glu Asp Ile Lys Glu 
65                  70                  75                  80  


Leu Phe Leu Asp Leu Ala Leu Met Ser Gln Gly Ser Ser Val Leu Asn 
                85                  90                  95      


Phe Ser Tyr Pro Ile Cys Glu Ala Ala Leu Pro Lys Phe Ser Phe Cys 
            100                 105                 110         


Gly Arg Arg Lys Gly Glu Gln Ile Tyr Tyr Ala Gly Pro Val Asn Asn 
        115                 120                 125             


Pro Glu Phe Thr Ile Pro Gln Gly Glu Tyr Gln Val Leu Leu Glu Leu 
    130                 135                 140                 


Tyr Thr Glu Lys Arg Ser Thr Val Ala Cys Ala Asn Ala Thr Ile Met 
145                 150                 155                 160 


Cys Ser 
        


<210>  8196
<211>  162
<212>  PRT
<213>  Homo Sapiens

<400>  8196

Met Lys Gly Phe Thr Ala Thr Leu Phe Leu Trp Thr Leu Ile Phe Pro 
1               5                   10                  15      


Ser Cys Ser Gly Gly Gly Gly Gly Lys Ala Trp Pro Thr His Val Val 
            20                  25                  30          


Cys Ser Asp Ser Gly Leu Glu Val Leu Tyr Gln Ser Cys Asp Pro Leu 
        35                  40                  45              


Gln Asp Phe Gly Phe Ser Val Glu Lys Cys Ser Lys Gln Leu Lys Ser 
    50                  55                  60                  


Asn Ile Asn Ile Arg Phe Gly Ile Ile Leu Arg Glu Asp Ile Lys Glu 
65                  70                  75                  80  


Leu Phe Leu Asp Leu Ala Leu Met Ser Gln Gly Ser Ser Val Leu Asn 
                85                  90                  95      


Phe Ser Tyr Pro Ile Cys Glu Ala Ala Leu Pro Lys Phe Ser Phe Cys 
            100                 105                 110         


Gly Arg Arg Lys Gly Glu Gln Ile Tyr Tyr Ala Gly Pro Val Asn Asn 
        115                 120                 125             


Pro Glu Phe Thr Ile Pro Gln Gly Glu Tyr Gln Val Leu Leu Glu Leu 
    130                 135                 140                 


Tyr Thr Glu Lys Arg Ser Thr Val Ala Cys Ala Asn Ala Thr Ile Met 
145                 150                 155                 160 


Cys Ser 
        


<210>  8197
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  8197

Met Leu Pro Phe Leu Phe Phe Ser Thr Leu Phe Ser Ser Ile Phe Thr 
1               5                   10                  15      


Glu Ala Gln Lys Gln Tyr Trp Val Cys Asn Ser Ser Asp Ala Ser Ile 
            20                  25                  30          


Ser Tyr Thr Tyr Cys Asp Lys Met Gln Tyr Pro Ile Ser Ile Asn Val 
        35                  40                  45              


Asn Pro Cys Ile Glu Leu Lys Arg Ser Lys Gly Leu Leu His Ile Phe 
    50                  55                  60                  


Tyr Ile Pro Arg Arg Asp Leu Lys Gln Leu Tyr Phe Asn Leu Tyr Ile 
65                  70                  75                  80  


Thr Val Asn Thr Met Asn Leu Pro Lys Arg Lys Glu Val Ile Cys Arg 
                85                  90                  95      


Gly Ser Asp Asp Asp Tyr Ser Phe Cys Arg Ala Leu Lys Gly Glu Thr 
            100                 105                 110         


Val Asn Thr Thr Ile Ser Phe Ser Phe Lys Gly Ile Lys Phe Ser Lys 
        115                 120                 125             


Gly Lys Tyr Lys Cys Val Val Glu Ala Ile Ser Gly Ser Pro Glu Glu 
    130                 135                 140                 


Met Leu Phe Cys Leu Glu Phe Val Ile Leu His Gln Pro Asn Ser Asn 
145                 150                 155                 160 


<210>  8198
<211>  130
<212>  PRT
<213>  Homo Sapiens

<400>  8198

Met Leu Pro Phe Leu Phe Phe Ser Thr Leu Phe Ser Ser Ile Phe Thr 
1               5                   10                  15      


Glu Ala Gln Lys Gln Tyr Trp Val Cys Asn Ser Ser Asp Ala Ser Ile 
            20                  25                  30          


Ser Tyr Thr Tyr Cys Gly Arg Asp Leu Lys Gln Leu Tyr Phe Asn Leu 
        35                  40                  45              


Tyr Ile Thr Val Asn Thr Met Asn Leu Pro Lys Arg Lys Glu Val Ile 
    50                  55                  60                  


Cys Arg Gly Ser Asp Asp Asp Tyr Ser Phe Cys Arg Ala Leu Lys Gly 
65                  70                  75                  80  


Glu Thr Val Asn Thr Thr Ile Ser Phe Ser Phe Lys Gly Ile Lys Phe 
                85                  90                  95      


Ser Lys Gly Lys Tyr Lys Cys Val Val Glu Ala Ile Ser Gly Ser Pro 
            100                 105                 110         


Glu Glu Met Leu Phe Cys Leu Glu Phe Val Ile Leu His Gln Pro Asn 
        115                 120                 125             


Ser Asn 
    130 


<210>  8199
<211>  194
<212>  PRT
<213>  Homo Sapiens

<400>  8199

Met Ser Ala Leu Trp Leu Leu Leu Gly Leu Leu Ala Leu Met Asp Leu 
1               5                   10                  15      


Ser Glu Ser Ser Asn Trp Gly Cys Tyr Gly Asn Ile Gln Ser Leu Asp 
            20                  25                  30          


Thr Pro Gly Ala Ser Cys Gly Ile Gly Arg Arg His Gly Leu Asn Tyr 
        35                  40                  45              


Cys Gly Val Arg Ala Ser Glu Arg Leu Ala Glu Ile Asp Met Pro Tyr 
    50                  55                  60                  


Leu Leu Lys Tyr Gln Pro Met Met Gln Thr Ile Gly Gln Lys Tyr Cys 
65                  70                  75                  80  


Met Asp Pro Ala Val Ile Ala Gly Val Leu Ser Arg Lys Ser Pro Gly 
                85                  90                  95      


Asp Lys Ile Leu Val Asn Met Gly Asp Arg Thr Ser Met Val Gln Asp 
            100                 105                 110         


Pro Gly Ser Gln Ala Pro Thr Ser Trp Ile Ser Glu Ser Gln Val Ser 
        115                 120                 125             


Gln Thr Thr Glu Val Leu Thr Thr Arg Ile Lys Glu Ile Gln Arg Arg 
    130                 135                 140                 


Phe Pro Thr Trp Thr Pro Asp Gln Tyr Leu Arg Gly Gly Leu Cys Ala 
145                 150                 155                 160 


Tyr Ser Gly Gly Ala Gly Tyr Val Arg Ser Ser Gln Asp Leu Ser Cys 
                165                 170                 175     


Asp Phe Cys Asn Asp Val Leu Ala Arg Ala Lys Tyr Leu Lys Arg His 
            180                 185                 190         


Gly Phe 
        


<210>  8200
<211>  194
<212>  PRT
<213>  Homo Sapiens

<400>  8200

Met Ser Ala Leu Trp Leu Leu Leu Gly Leu Leu Ala Leu Met Asp Leu 
1               5                   10                  15      


Ser Glu Ser Ser Asn Trp Gly Cys Tyr Gly Asn Ile Gln Ser Leu Asp 
            20                  25                  30          


Thr Pro Gly Ala Ser Cys Gly Ile Gly Arg Arg His Gly Leu Asn Tyr 
        35                  40                  45              


Cys Gly Val Arg Ala Ser Glu Arg Leu Ala Glu Ile Asp Met Pro Tyr 
    50                  55                  60                  


Leu Leu Lys Tyr Gln Pro Met Met Gln Thr Ile Gly Gln Lys Tyr Cys 
65                  70                  75                  80  


Met Asp Pro Ala Val Ile Ala Gly Val Leu Ser Arg Lys Ser Pro Gly 
                85                  90                  95      


Asp Lys Ile Leu Val Asn Met Gly Asp Arg Thr Ser Met Val Gln Asp 
            100                 105                 110         


Pro Gly Ser Gln Ala Pro Thr Ser Trp Ile Ser Glu Ser Gln Val Ser 
        115                 120                 125             


Gln Thr Thr Glu Val Leu Thr Thr Arg Ile Lys Glu Ile Gln Arg Arg 
    130                 135                 140                 


Phe Pro Thr Trp Thr Pro Asp Gln Tyr Leu Arg Gly Gly Leu Cys Ala 
145                 150                 155                 160 


Tyr Ser Gly Gly Ala Gly Tyr Val Arg Ser Ser Gln Asp Leu Ser Cys 
                165                 170                 175     


Asp Phe Cys Asn Asp Val Leu Ala Arg Ala Lys Tyr Leu Lys Arg His 
            180                 185                 190         


Gly Phe 
        


<210>  8201
<211>  169
<212>  PRT
<213>  Homo Sapiens

<400>  8201

Met Leu Ser Ser Val Val Phe Trp Gly Leu Ile Ala Leu Ile Gly Thr 
1               5                   10                  15      


Ser Arg Gly Ser Tyr Pro Phe Ser His Ser Met Lys Pro His Leu His 
            20                  25                  30          


Pro Arg Leu Tyr His Gly Cys Tyr Gly Asp Ile Met Thr Met Lys Thr 
        35                  40                  45              


Ser Gly Ala Thr Cys Asp Ala Asn Ser Val Met Asn Cys Gly Ile Arg 
    50                  55                  60                  


Gly Ser Glu Met Phe Ala Glu Met Asp Leu Arg Ala Ile Lys Pro Tyr 
65                  70                  75                  80  


Gln Thr Leu Ile Lys Glu Val Gly Gln Arg His Cys Val Asp Pro Ala 
                85                  90                  95      


Val Ile Ala Ala Ile Ile Ser Arg Glu Ser His Gly Gly Ser Val Leu 
            100                 105                 110         


Gln Asp Gly Trp Asp His Arg Gly Leu Lys Phe Gly Leu Met Gln Leu 
        115                 120                 125             


Asp Lys Gln Thr Tyr His Pro Val Gly Ala Trp Asp Ser Lys Glu His 
    130                 135                 140                 


Leu Ser Gln Ala Thr Gly Ile Leu Thr Glu Arg Ile Lys Ala Ile Gln 
145                 150                 155                 160 


Lys Lys Phe Pro Thr Trp Ser Val Ala 
                165                 


<210>  8202
<211>  178
<212>  PRT
<213>  Homo Sapiens

<400>  8202

Met Leu Ser Ser Val Val Phe Trp Gly Leu Ile Ala Leu Ile Gly Thr 
1               5                   10                  15      


Ser Arg Gly Ser Tyr Pro Phe Ser His Ser Met Lys Pro His Leu His 
            20                  25                  30          


Pro Arg Leu Tyr His Gly Cys Tyr Gly Asp Ile Met Thr Met Lys Thr 
        35                  40                  45              


Ser Gly Ala Thr Cys Asp Ala Asn Ser Val Met Asn Cys Gly Ile Arg 
    50                  55                  60                  


Gly Ser Glu Met Phe Ala Glu Met Asp Leu Arg Ala Ile Lys Pro Tyr 
65                  70                  75                  80  


Gln Thr Leu Ile Lys Glu Val Gly Gln Arg His Cys Val Asp Pro Ala 
                85                  90                  95      


Val Ile Ala Ala Ile Ile Ser Arg Glu Ser His Gly Gly Ser Val Leu 
            100                 105                 110         


Gln Asp Gly Trp Asp His Arg Gly Leu Lys Phe Gly Leu Met Gln Leu 
        115                 120                 125             


Asp Lys Gln Thr Tyr His Pro Val Gly Ala Trp Asp Ser Lys Glu His 
    130                 135                 140                 


Leu Ser Gln Ala Thr Gly Ile Leu Thr Glu Arg Ile Lys Ala Ile Gln 
145                 150                 155                 160 


Lys Lys Phe Pro Thr Trp Ser Val Ala Gln His Leu Lys Gly Phe Phe 
                165                 170                 175     


Leu Leu 
        


<210>  8203
<211>  178
<212>  PRT
<213>  Homo Sapiens

<400>  8203

Met Leu Ser Ser Val Val Phe Trp Gly Leu Ile Ala Leu Ile Gly Thr 
1               5                   10                  15      


Ser Arg Gly Ser Tyr Pro Phe Ser His Ser Met Lys Pro His Leu His 
            20                  25                  30          


Pro Arg Leu Tyr His Gly Cys Tyr Gly Asp Ile Met Thr Met Lys Thr 
        35                  40                  45              


Ser Gly Ala Thr Cys Asp Ala Asn Ser Val Met Asn Cys Gly Ile Arg 
    50                  55                  60                  


Gly Ser Glu Met Phe Ala Glu Met Asp Leu Arg Ala Ile Lys Pro Tyr 
65                  70                  75                  80  


Gln Thr Leu Ile Lys Glu Val Gly Gln Arg His Cys Val Asp Pro Ala 
                85                  90                  95      


Val Ile Ala Ala Ile Ile Ser Arg Glu Ser His Gly Gly Ser Val Leu 
            100                 105                 110         


Gln Asp Gly Trp Asp His Arg Gly Leu Lys Phe Gly Leu Met Gln Leu 
        115                 120                 125             


Asp Lys Gln Thr Tyr His Pro Val Gly Ala Trp Asp Ser Lys Glu His 
    130                 135                 140                 


Leu Ser Gln Ala Thr Gly Ile Leu Thr Glu Arg Ile Lys Ala Ile Gln 
145                 150                 155                 160 


Lys Lys Phe Pro Thr Trp Ser Val Ala Gln His Leu Lys Gly Phe Phe 
                165                 170                 175     


Leu Leu 
        


<210>  8204
<211>  212
<212>  PRT
<213>  Homo Sapiens

<400>  8204

Met Leu Ser Ser Val Val Phe Trp Gly Leu Ile Ala Leu Ile Gly Thr 
1               5                   10                  15      


Ser Arg Gly Ser Tyr Pro Phe Ser His Ser Met Lys Pro His Leu His 
            20                  25                  30          


Pro Arg Leu Tyr His Gly Cys Tyr Gly Asp Ile Met Thr Met Lys Thr 
        35                  40                  45              


Ser Gly Ala Thr Cys Asp Ala Asn Ser Val Met Asn Cys Gly Ile Arg 
    50                  55                  60                  


Gly Ser Glu Met Phe Ala Glu Met Asp Leu Arg Ala Ile Lys Pro Tyr 
65                  70                  75                  80  


Gln Thr Leu Ile Lys Glu Val Gly Gln Arg His Cys Val Asp Pro Ala 
                85                  90                  95      


Val Ile Ala Ala Ile Ile Ser Arg Glu Ser His Gly Gly Ser Val Leu 
            100                 105                 110         


Gln Asp Gly Trp Asp His Arg Gly Leu Lys Phe Gly Leu Met Gln Leu 
        115                 120                 125             


Asp Lys Gln Thr Tyr His Pro Val Gly Ala Trp Asp Ser Lys Glu His 
    130                 135                 140                 


Leu Ser Gln Ala Thr Gly Ile Leu Thr Glu Arg Ile Lys Ala Ile Gln 
145                 150                 155                 160 


Lys Lys Phe Pro Thr Trp Ser Val Ala Gln His Leu Lys Gly Gly Leu 
                165                 170                 175     


Ser Ala Phe Lys Ser Gly Ile Glu Ala Ile Ala Thr Pro Ser Asp Ile 
            180                 185                 190         


Asp Asn Asp Phe Val Asn Asp Ile Ile Ala Arg Ala Lys Phe Tyr Lys 
        195                 200                 205             


Arg Gln Ser Phe 
    210         


<210>  8205
<211>  212
<212>  PRT
<213>  Homo Sapiens

<400>  8205

Met Leu Ser Ser Val Val Phe Trp Gly Leu Ile Ala Leu Ile Gly Thr 
1               5                   10                  15      


Ser Arg Gly Ser Tyr Pro Phe Ser His Ser Met Lys Pro His Leu His 
            20                  25                  30          


Pro Arg Leu Tyr His Gly Cys Tyr Gly Asp Ile Met Thr Met Lys Thr 
        35                  40                  45              


Ser Gly Ala Thr Cys Asp Ala Asn Ser Val Met Asn Cys Gly Ile Arg 
    50                  55                  60                  


Gly Ser Glu Met Phe Ala Glu Met Asp Leu Arg Ala Ile Lys Pro Tyr 
65                  70                  75                  80  


Gln Thr Leu Ile Lys Glu Val Gly Gln Arg His Cys Val Asp Pro Ala 
                85                  90                  95      


Val Ile Ala Ala Ile Ile Ser Arg Glu Ser His Gly Gly Ser Val Leu 
            100                 105                 110         


Gln Asp Gly Trp Asp His Arg Gly Leu Lys Phe Gly Leu Met Gln Leu 
        115                 120                 125             


Asp Lys Gln Thr Tyr His Pro Val Gly Ala Trp Asp Ser Lys Glu His 
    130                 135                 140                 


Leu Ser Gln Ala Thr Gly Ile Leu Thr Glu Arg Ile Lys Ala Ile Gln 
145                 150                 155                 160 


Lys Lys Phe Pro Thr Trp Ser Val Ala Gln His Leu Lys Gly Gly Leu 
                165                 170                 175     


Ser Ala Phe Lys Ser Gly Ile Glu Ala Ile Ala Thr Pro Ser Asp Ile 
            180                 185                 190         


Asp Asn Asp Phe Val Asn Asp Ile Ile Ala Arg Ala Lys Phe Tyr Lys 
        195                 200                 205             


Arg Gln Ser Phe 
    210         


<210>  8206
<211>  182
<212>  PRT
<213>  Homo Sapiens

<400>  8206

Met Leu Ser Ser Val Val Phe Trp Gly Leu Ile Ala Leu Ile Gly Thr 
1               5                   10                  15      


Ser Arg Gly Ser Tyr Pro Phe Ser His Ser Met Lys Pro His Leu His 
            20                  25                  30          


Pro Arg Leu Tyr His Gly Cys Tyr Gly Asp Ile Met Thr Met Lys Thr 
        35                  40                  45              


Ser Gly Ala Thr Cys Asp Ala Asn Ser Val Met Asn Cys Gly Ile Arg 
    50                  55                  60                  


Gly Ser Glu Met Phe Ala Glu Met Asp Leu Arg Ala Ile Lys Pro Tyr 
65                  70                  75                  80  


Gln Thr Leu Ile Lys Glu Val Gly Gln Arg His Cys Val Asp Pro Ala 
                85                  90                  95      


Val Ile Ala Ala Ile Ile Ser Arg Glu Ser His Gly Gly Ser Val Leu 
            100                 105                 110         


Gln Asp Gly Trp Asp His Arg Gly Leu Lys Phe Gly Leu Met Gln Leu 
        115                 120                 125             


Asp Lys Gln Thr Tyr His Pro Val Gly Ala Trp Asp Ser Lys Glu His 
    130                 135                 140                 


Leu Ser Gln Ala Thr Gly Ile Leu Thr Glu Arg Ile Lys Ala Ile Gln 
145                 150                 155                 160 


Lys Lys Phe Pro Thr Trp Ser Val Ala Gln His Leu Lys Gly Arg Leu 
                165                 170                 175     


Tyr Ser Glu Tyr Phe Val 
            180         


<210>  8207
<211>  82
<212>  PRT
<213>  Homo Sapiens

<400>  8207

Met Thr Pro Leu Leu Thr Leu Ile Leu Val Val Leu Met Gly Leu Pro 
1               5                   10                  15      


Leu Ala Gln Ala Leu Asp Cys His Val Cys Ala Tyr Asn Gly Asp Asn 
            20                  25                  30          


Cys Phe Asn Pro Met Arg Cys Pro Ala Met Val Ala Tyr Cys Met Thr 
        35                  40                  45              


Thr Arg Thr Tyr Tyr Thr Pro Thr Arg Met Lys Val Ser Lys Ser Cys 
    50                  55                  60                  


Val Pro Arg Cys Phe Glu Thr Val Tyr Asp Gly Tyr Ser Lys His Ala 
65                  70                  75                  80  


Ser Thr 
        


<210>  8208
<211>  84
<212>  PRT
<213>  Homo Sapiens

<400>  8208

Met Thr Pro Leu Leu Thr Leu Ile Leu Val Val Leu Met Gly Leu Pro 
1               5                   10                  15      


Leu Ala Gln Ala Leu Asp Cys His Val Cys Ala Tyr Asn Gly Asp Asn 
            20                  25                  30          


Cys Phe Asn Pro Met Arg Cys Pro Ala Met Val Ala Tyr Cys Met Thr 
        35                  40                  45              


Thr Arg Thr Tyr Tyr Thr Pro Thr Arg Met Lys Val Ser Lys Ser Cys 
    50                  55                  60                  


Val Pro Arg Cys Phe Glu Thr Val Tyr Asp Gly Tyr Ser Lys His Ala 
65                  70                  75                  80  


Ser Thr Thr Ser 
                


<210>  8209
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  8209

Met Thr Pro Leu Leu Thr Leu Ile Leu Val Val Leu Met Gly Leu Pro 
1               5                   10                  15      


Leu Ala Gln Ala Leu Asp Cys His Val Cys Ala Tyr Asn Gly Asp Asn 
            20                  25                  30          


Cys Phe Asn Pro Met Arg Cys Pro Ala Met Val Ala Tyr Cys Met Thr 
        35                  40                  45              


Thr Arg Thr Tyr Tyr Thr Pro Thr Arg Met Lys Val Ser Lys Ser Cys 
    50                  55                  60                  


Val Pro Arg Cys Phe Glu Thr Val Tyr Asp Gly Tyr Ser Lys His Ala 
65                  70                  75                  80  


Ser Thr Thr Ser Cys Cys Gln Tyr Asp Leu Cys Asn Gly Thr Gly Leu 
                85                  90                  95      


Ala Thr Pro Ala Thr Leu Ala Leu Ala Pro Ile Leu Leu Ala Thr Leu 
            100                 105                 110         


Trp Gly Leu Leu 
        115     


<210>  8210
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  8210

Met Thr Pro Leu Leu Thr Leu Ile Leu Val Val Leu Met Gly Leu Pro 
1               5                   10                  15      


Leu Ala Gln Ala Leu Asp Cys His Val Cys Ala Tyr Asn Gly Asp Asn 
            20                  25                  30          


Cys Phe Asn Pro Met Arg Cys Pro Ala Met Val Ala Tyr Cys Met Thr 
        35                  40                  45              


Thr Arg Thr Tyr Tyr Thr Pro Thr Arg Met Lys Val Ser Lys Ser Cys 
    50                  55                  60                  


Val Pro Arg Cys Phe Glu Thr Val Tyr Asp Gly Tyr Ser Lys His Ala 
65                  70                  75                  80  


Ser Thr Thr Ser Cys Cys Gln Tyr Asp Leu Cys Asn Gly Thr Gly Leu 
                85                  90                  95      


Ala Thr Pro Ala Thr Leu Ala Leu Ala Pro Ile Leu Leu Ala Thr Leu 
            100                 105                 110         


Trp Gly Leu Leu 
        115     


<210>  8211
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  8211

Met Thr Pro Leu Leu Thr Leu Ile Leu Val Val Leu Met Gly Leu Pro 
1               5                   10                  15      


Leu Ala Gln Ala Leu Asp Cys His Val Cys Ala Tyr Asn Gly Asp Asn 
            20                  25                  30          


Cys Phe Asn Pro Met Arg Cys Pro Ala Met Val Ala Tyr Cys Met Thr 
        35                  40                  45              


Thr Arg Thr Tyr Tyr Thr Pro Thr Arg Met Lys Val Ser Lys Ser Cys 
    50                  55                  60                  


Val Pro Arg Cys Phe Glu Thr Val Tyr Asp Gly Tyr Ser Lys His Ala 
65                  70                  75                  80  


Ser Thr Thr Ser Cys Cys Gln Tyr Asp Leu Cys Asn Gly Thr Gly Leu 
                85                  90                  95      


Ala Thr Pro Ala Thr Leu Ala Leu Ala Pro Ile Leu Leu Ala Thr Leu 
            100                 105                 110         


Trp Gly Leu Leu 
        115     


<210>  8212
<211>  89
<212>  PRT
<213>  Homo Sapiens

<400>  8212

Met Cys Gln Lys Glu Val Met Glu Gln Ser Ala Gly Ile Met Tyr Arg 
1               5                   10                  15      


Lys Ser Cys Ala Ser Ser Ala Ala Cys Leu Ile Ala Ser Ala Gly Tyr 
            20                  25                  30          


Gln Ser Phe Cys Ser Pro Gly Lys Leu Asn Ser Val Cys Ile Ser Cys 
        35                  40                  45              


Cys Asn Thr Pro Leu Cys Asn Gly Pro Arg Pro Lys Lys Arg Gly Ser 
    50                  55                  60                  


Ser Ala Ser Ala Leu Arg Pro Gly Leu Arg Thr Thr Ile Leu Phe Leu 
65                  70                  75                  80  


Lys Leu Ala Leu Phe Ser Ala His Cys 
                85                  


<210>  8213
<211>  39
<212>  PRT
<213>  Homo Sapiens

<400>  8213

Met Trp Val Leu Gly Ile Ala Ala Thr Phe Cys Gly Leu Phe Leu Leu 
1               5                   10                  15      


Pro Gly Glu Asn Thr Gln Arg Pro Ala Ala Glu Ala Arg Leu Cys Ala 
            20                  25                  30          


Ala Asn Pro Val Leu Pro Val 
        35                  


<210>  8214
<211>  141
<212>  PRT
<213>  Homo Sapiens

<400>  8214

Met Trp Val Leu Gly Ile Ala Ala Thr Phe Cys Gly Leu Phe Leu Leu 
1               5                   10                  15      


Pro Gly Phe Ala Leu Gln Ile Gln Cys Tyr Gln Cys Glu Glu Phe Gln 
            20                  25                  30          


Leu Asn Asn Asp Cys Ser Ser Pro Glu Phe Ile Val Asn Cys Thr Val 
        35                  40                  45              


Asn Val Gln Asp Met Cys Gln Lys Glu Val Met Glu Gln Ser Ala Gly 
    50                  55                  60                  


Ile Met Tyr Arg Lys Ser Cys Ala Ser Ser Ala Ala Cys Leu Ile Ala 
65                  70                  75                  80  


Ser Ala Gly Tyr Gln Ser Phe Cys Ser Pro Gly Lys Leu Asn Ser Val 
                85                  90                  95      


Cys Ile Ser Cys Cys Asn Thr Pro Leu Cys Asn Gly Pro Arg Pro Lys 
            100                 105                 110         


Lys Arg Gly Ser Ser Ala Ser Ala Leu Arg Pro Gly Leu Arg Thr Thr 
        115                 120                 125             


Ile Leu Phe Leu Lys Leu Ala Leu Phe Ser Ala His Cys 
    130                 135                 140     


<210>  8215
<211>  125
<212>  PRT
<213>  Homo Sapiens

<400>  8215

Met Arg Gly Thr Arg Leu Ala Leu Leu Ala Leu Val Leu Ala Ala Cys 
1               5                   10                  15      


Gly Glu Leu Ala Pro Ala Leu Arg Cys Tyr Val Cys Pro Glu Pro Thr 
            20                  25                  30          


Gly Val Ser Asp Cys Val Thr Ile Ala Thr Cys Thr Thr Asn Glu Thr 
        35                  40                  45              


Met Cys Lys Thr Thr Leu Tyr Ser Arg Glu Ile Val Tyr Pro Phe Gln 
    50                  55                  60                  


Gly Asp Ser Thr Val Thr Lys Ser Cys Ala Ser Lys Cys Lys Pro Ser 
65                  70                  75                  80  


Asp Val Asp Gly Ile Gly Gln Thr Leu Pro Val Ser Cys Cys Asn Thr 
                85                  90                  95      


Glu Leu Cys Asn Val Asp Gly Ala Pro Ala Leu Asn Ser Leu His Cys 
            100                 105                 110         


Gly Ala Leu Thr Leu Leu Pro Leu Leu Ser Leu Arg Leu 
        115                 120                 125 


<210>  8216
<211>  246
<212>  PRT
<213>  Homo Sapiens

<400>  8216

Met Gly Pro Gln His Leu Arg Leu Val Gln Leu Phe Cys Leu Leu Gly 
1               5                   10                  15      


Ala Ile Ser Thr Leu Pro Arg Ala Gly Ala Leu Leu Cys Tyr Glu Ala 
            20                  25                  30          


Thr Ala Ser Arg Phe Arg Ala Val Ala Phe His Asn Trp Lys Trp Leu 
        35                  40                  45              


Leu Met Arg Asn Met Val Cys Lys Leu Gln Glu Gly Cys Glu Glu Thr 
    50                  55                  60                  


Leu Val Phe Ile Glu Thr Gly Thr Ala Arg Gly Val Val Gly Phe Lys 
65                  70                  75                  80  


Gly Cys Ser Ser Ser Ser Ser Tyr Pro Ala Gln Ile Ser Tyr Leu Val 
                85                  90                  95      


Ser Pro Pro Gly Val Ser Ile Ala Ser Tyr Ser Arg Val Cys Arg Ser 
            100                 105                 110         


Tyr Leu Cys Asn Asn Leu Thr Asn Leu Glu Pro Phe Val Lys Leu Lys 
        115                 120                 125             


Ala Ser Thr Pro Lys Ser Ile Thr Ser Ala Ser Cys Ser Cys Pro Thr 
    130                 135                 140                 


Cys Val Gly Glu His Met Lys Asp Cys Leu Pro Asn Phe Val Thr Thr 
145                 150                 155                 160 


Asn Ser Cys Pro Leu Ala Ala Ser Thr Cys Tyr Ser Ser Thr Leu Lys 
                165                 170                 175     


Phe Gln Ala Gly Phe Leu Asn Thr Thr Phe Leu Leu Met Gly Cys Ala 
            180                 185                 190         


Arg Glu His Asn Gln Leu Leu Ala Asp Phe His His Ile Gly Ser Ile 
        195                 200                 205             


Lys Val Thr Glu Val Leu Asn Ile Leu Glu Lys Ser Gln Ile Val Gly 
    210                 215                 220                 


Ala Ala Ser Ser Arg Gln Asp Pro Ala Trp Gly Val Val Leu Gly Leu 
225                 230                 235                 240 


Leu Phe Ala Phe Arg Asp 
                245     


<210>  8217
<211>  211
<212>  PRT
<213>  Homo Sapiens

<400>  8217

Met Gly Pro Gln His Leu Arg Leu Val Gln Leu Phe Cys Leu Leu Gly 
1               5                   10                  15      


Ala Ile Ser Thr Leu Pro Arg Met Ser Cys Gly Ala Gly Cys Tyr Lys 
            20                  25                  30          


Thr Gln Lys Gly Thr Ala Arg Gly Val Val Gly Phe Lys Gly Cys Ser 
        35                  40                  45              


Ser Ser Ser Ser Tyr Pro Ala Gln Ile Ser Tyr Leu Val Ser Pro Pro 
    50                  55                  60                  


Gly Val Ser Ile Ala Ser Tyr Ser Arg Val Cys Arg Ser Tyr Leu Cys 
65                  70                  75                  80  


Asn Asn Leu Thr Asn Leu Glu Pro Phe Val Lys Leu Lys Ala Ser Thr 
                85                  90                  95      


Pro Lys Ser Ile Thr Ser Ala Ser Cys Ser Cys Pro Thr Cys Val Gly 
            100                 105                 110         


Glu His Met Lys Asp Cys Leu Pro Asn Phe Val Thr Thr Asn Ser Cys 
        115                 120                 125             


Pro Leu Ala Ala Ser Thr Cys Tyr Ser Ser Thr Leu Lys Phe Gln Ala 
    130                 135                 140                 


Gly Phe Leu Asn Thr Thr Phe Leu Leu Met Gly Cys Ala Arg Glu His 
145                 150                 155                 160 


Asn Gln Leu Leu Ala Asp Phe His His Ile Gly Ser Ile Lys Val Thr 
                165                 170                 175     


Glu Val Leu Asn Ile Leu Glu Lys Ser Gln Ile Val Gly Ala Ala Ser 
            180                 185                 190         


Ser Arg Gln Asp Pro Ala Trp Gly Val Val Leu Gly Leu Leu Phe Ala 
        195                 200                 205             


Phe Arg Asp 
    210     


<210>  8218
<211>  211
<212>  PRT
<213>  Homo Sapiens

<400>  8218

Met Gly Pro Gln His Leu Arg Leu Val Gln Leu Phe Cys Leu Leu Gly 
1               5                   10                  15      


Ala Ile Ser Thr Leu Pro Arg Met Ser Cys Gly Ala Gly Cys Tyr Lys 
            20                  25                  30          


Thr Gln Lys Gly Thr Ala Arg Gly Val Val Gly Phe Lys Gly Cys Ser 
        35                  40                  45              


Ser Ser Ser Ser Tyr Pro Ala Gln Ile Ser Tyr Leu Val Ser Pro Pro 
    50                  55                  60                  


Gly Val Ser Ile Ala Ser Tyr Ser Arg Val Cys Arg Ser Tyr Leu Cys 
65                  70                  75                  80  


Asn Asn Leu Thr Asn Leu Glu Pro Phe Val Lys Leu Lys Ala Ser Thr 
                85                  90                  95      


Pro Lys Ser Ile Thr Ser Ala Ser Cys Ser Cys Pro Thr Cys Val Gly 
            100                 105                 110         


Glu His Met Lys Asp Cys Leu Pro Asn Phe Val Thr Thr Asn Ser Cys 
        115                 120                 125             


Pro Leu Ala Ala Ser Thr Cys Tyr Ser Ser Thr Leu Lys Phe Gln Ala 
    130                 135                 140                 


Gly Phe Leu Asn Thr Thr Phe Leu Leu Met Gly Cys Ala Arg Glu His 
145                 150                 155                 160 


Asn Gln Leu Leu Ala Asp Phe His His Ile Gly Ser Ile Lys Val Thr 
                165                 170                 175     


Glu Val Leu Asn Ile Leu Glu Lys Ser Gln Ile Val Gly Ala Ala Ser 
            180                 185                 190         


Ser Arg Gln Asp Pro Ala Trp Gly Val Val Leu Gly Leu Leu Phe Ala 
        195                 200                 205             


Phe Arg Asp 
    210     


<210>  8219
<211>  53
<212>  PRT
<213>  Homo Sapiens

<400>  8219

Met Glu Pro Gly Pro Ala Leu Ala Trp Leu Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Ala Asp Cys Leu Lys Ala Ala Gln Ser Arg Asp Phe Thr Val Lys Asp 
            20                  25                  30          


Ile Ile Tyr Leu His Pro Ser Thr Thr Pro Tyr Pro Gly Gly Phe Lys 
        35                  40                  45              


Cys Phe Thr Cys Glu 
    50              


<210>  8220
<211>  171
<212>  PRT
<213>  Homo Sapiens

<400>  8220

Met Glu Pro Gly Pro Ala Leu Ala Trp Leu Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Ala Asp Cys Leu Lys Ala Ala Gln Ser Arg Asp Phe Thr Val Lys Asp 
            20                  25                  30          


Ile Ile Tyr Leu His Pro Ser Thr Thr Pro Tyr Pro Gly Gly Phe Lys 
        35                  40                  45              


Cys Phe Thr Cys Glu Lys Ala Ala Asp Asn Tyr Glu Cys Asn Arg Trp 
    50                  55                  60                  


Ala Pro Asp Ile Tyr Cys Pro Arg Glu Thr Arg Tyr Cys Tyr Thr Gln 
65                  70                  75                  80  


His Thr Met Glu Val Thr Gly Asn Ser Ile Ser Val Thr Lys Arg Cys 
                85                  90                  95      


Val Pro Leu Glu Glu Cys Leu Ser Thr Gly Cys Arg Asp Ser Glu His 
            100                 105                 110         


Glu Gly His Lys Val Cys Thr Ser Cys Cys Glu Gly Asn Ile Cys Asn 
        115                 120                 125             


Leu Pro Leu Pro Arg Asn Glu Thr Asp Ala Thr Phe Ala Thr Thr Ser 
    130                 135                 140                 


Pro Ile Asn Gln Thr Asn Gly His Pro Arg Cys Met Ser Val Ile Val 
145                 150                 155                 160 


Ser Cys Leu Trp Leu Trp Leu Gly Leu Met Leu 
                165                 170     


<210>  8221
<211>  171
<212>  PRT
<213>  Homo Sapiens

<400>  8221

Met Glu Pro Gly Pro Ala Leu Ala Trp Leu Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Ala Asp Cys Leu Lys Ala Ala Gln Ser Arg Asp Phe Thr Val Lys Asp 
            20                  25                  30          


Ile Ile Tyr Leu His Pro Ser Thr Thr Pro Tyr Pro Gly Gly Phe Lys 
        35                  40                  45              


Cys Phe Thr Cys Glu Lys Ala Ala Asp Asn Tyr Glu Cys Asn Arg Trp 
    50                  55                  60                  


Ala Pro Asp Ile Tyr Cys Pro Arg Glu Thr Arg Tyr Cys Tyr Thr Gln 
65                  70                  75                  80  


His Thr Met Glu Val Thr Gly Asn Ser Ile Ser Val Thr Lys Arg Cys 
                85                  90                  95      


Val Pro Leu Glu Glu Cys Leu Ser Thr Gly Cys Arg Asp Ser Glu His 
            100                 105                 110         


Glu Gly His Lys Val Cys Thr Ser Cys Cys Glu Gly Asn Ile Cys Asn 
        115                 120                 125             


Leu Pro Leu Pro Arg Asn Glu Thr Asp Ala Thr Phe Ala Thr Thr Ser 
    130                 135                 140                 


Pro Ile Asn Gln Thr Asn Gly His Pro Arg Cys Met Ser Val Ile Val 
145                 150                 155                 160 


Ser Cys Leu Trp Leu Trp Leu Gly Leu Met Leu 
                165                 170     


<210>  8222
<211>  76
<212>  PRT
<213>  Homo Sapiens

<400>  8222

Met Glu Pro Gly Pro Ala Leu Ala Trp Leu Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Ala Asp Cys Leu Lys Ala Ala Gln Ser Arg Asp Phe Thr Val Lys Asp 
            20                  25                  30          


Ile Ile Tyr Leu His Pro Ser Thr Thr Pro Tyr Pro Gly Gly Phe Lys 
        35                  40                  45              


Cys Phe Thr Cys Glu Lys Ala Ala Asp Asn Tyr Glu Cys Asn Arg Trp 
    50                  55                  60                  


Ala Pro Asp Ile Tyr Cys Pro Arg Gly Thr Met Ile 
65                  70                  75      


<210>  8223
<211>  76
<212>  PRT
<213>  Homo Sapiens

<400>  8223

Met Glu Pro Gly Pro Ala Leu Ala Trp Leu Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Ala Asp Cys Leu Lys Ala Ala Gln Ser Arg Asp Phe Thr Val Lys Asp 
            20                  25                  30          


Ile Ile Tyr Leu His Pro Ser Thr Thr Pro Tyr Pro Gly Gly Phe Lys 
        35                  40                  45              


Cys Phe Thr Cys Glu Lys Ala Ala Asp Asn Tyr Glu Cys Asn Arg Trp 
    50                  55                  60                  


Ala Pro Asp Ile Tyr Cys Pro Arg Gly Thr Met Ile 
65                  70                  75      


<210>  8224
<211>  50
<212>  PRT
<213>  Homo Sapiens

<400>  8224

Met Leu Cys Glu Arg His Cys Thr Glu Glu Asp Glu Asn His Ser Lys 
1               5                   10                  15      


Pro Asn Lys Gly Asn Ala Glu Glu Ile Phe Ser Ala Glu Tyr Trp Lys 
            20                  25                  30          


Val Arg Phe Pro Ala Ser Arg Ile Ser Gly Asn Val Asn Glu Gln His 
        35                  40                  45              


Glu Ala 
    50  


<210>  8225
<211>  74
<212>  PRT
<213>  Homo Sapiens

<400>  8225

Met Leu Leu Ile Thr Leu Ser Ala Asn Leu Phe Thr Val Pro Glu Arg 
1               5                   10                  15      


Ser Leu Thr Thr Thr Phe Ser Phe Ser Arg Cys Glu Arg His Cys Thr 
            20                  25                  30          


Glu Glu Asp Glu Asn His Ser Lys Pro Asn Lys Gly Asn Ala Glu Glu 
        35                  40                  45              


Ile Phe Ser Ala Glu Tyr Trp Lys Val Arg Phe Pro Ala Ser Arg Ile 
    50                  55                  60                  


Ser Gly Asn Val Asn Glu Gln His Glu Ala 
65                  70                  


<210>  8226
<211>  207
<212>  PRT
<213>  Homo Sapiens

<400>  8226

Met Leu Leu Ile Thr Leu Ser Ala Asn Leu Phe Thr Val Pro Glu Arg 
1               5                   10                  15      


Ser Leu Thr Thr Thr Phe Ser Phe Ser Arg Tyr Lys Ser Ser Asp Arg 
            20                  25                  30          


Pro Ala His Lys Val Ser Met Leu Leu Leu Cys His Ala Leu Ala Ile 
        35                  40                  45              


Ala Val Val Gln Ile Val Ile Phe Ser Glu Ser Trp Ala Phe Ala Lys 
    50                  55                  60                  


Asn Ile Asn Phe Tyr Asn Val Arg Pro Pro Leu Asp Pro Thr Pro Phe 
65                  70                  75                  80  


Pro Asn Ser Phe Lys Cys Phe Thr Cys Glu Asn Ala Gly Asp Asn Tyr 
                85                  90                  95      


Asn Cys Asn Arg Trp Ala Glu Asp Lys Trp Cys Pro Gln Asn Thr Gln 
            100                 105                 110         


Tyr Cys Leu Thr Val His His Phe Thr Ser His Gly Arg Ser Thr Ser 
        115                 120                 125             


Ile Thr Lys Lys Cys Ala Ser Arg Ser Glu Cys His Phe Val Gly Cys 
    130                 135                 140                 


His His Ser Arg Asp Ser Glu His Thr Glu Cys Arg Ser Cys Cys Glu 
145                 150                 155                 160 


Gly Met Ile Cys Asn Val Glu Leu Pro Thr Asn His Thr Asn Ala Val 
                165                 170                 175     


Phe Ala Val Met His Ala Gln Arg Thr Ser Gly Ser Ser Ala Pro Thr 
            180                 185                 190         


Leu Tyr Leu Pro Val Leu Ala Trp Val Phe Val Leu Pro Leu Leu 
        195                 200                 205         


<210>  8227
<211>  54
<212>  PRT
<213>  Homo Sapiens

<400>  8227

Met Leu Tyr Lys Ser Ser Asp Arg Pro Ala His Lys Val Ser Met Leu 
1               5                   10                  15      


Leu Leu Cys His Ala Leu Ala Ile Ala Val Val Gln Ile Val Ile Phe 
            20                  25                  30          


Ser Glu Ser Trp Ala Phe Ala Lys Asn Ile Asn Phe Tyr Asn Val Arg 
        35                  40                  45              


Pro Pro Leu Asp His Lys 
    50                  


<210>  8228
<211>  183
<212>  PRT
<213>  Homo Sapiens

<400>  8228

Met Leu Tyr Lys Ser Ser Asp Arg Pro Ala His Lys Val Ser Met Leu 
1               5                   10                  15      


Leu Leu Cys His Ala Leu Ala Ile Ala Val Val Gln Ile Val Ile Phe 
            20                  25                  30          


Ser Glu Ser Trp Ala Phe Ala Lys Asn Ile Asn Phe Tyr Asn Val Arg 
        35                  40                  45              


Pro Pro Leu Asp Pro Thr Pro Phe Pro Asn Ser Phe Lys Cys Phe Thr 
    50                  55                  60                  


Cys Glu Asn Ala Gly Asp Asn Tyr Asn Cys Asn Arg Trp Ala Glu Asp 
65                  70                  75                  80  


Lys Trp Cys Pro Gln Asn Thr Gln Tyr Cys Leu Thr Val His His Phe 
                85                  90                  95      


Thr Ser His Gly Arg Ser Thr Ser Ile Thr Lys Lys Cys Ala Ser Arg 
            100                 105                 110         


Ser Glu Cys His Phe Val Gly Cys His His Ser Arg Asp Ser Glu His 
        115                 120                 125             


Thr Glu Cys Arg Ser Cys Cys Glu Gly Met Ile Cys Asn Val Glu Leu 
    130                 135                 140                 


Pro Thr Asn His Thr Asn Ala Val Phe Ala Val Met His Ala Gln Arg 
145                 150                 155                 160 


Thr Ser Gly Ser Ser Ala Pro Thr Leu Tyr Leu Pro Val Leu Ala Trp 
                165                 170                 175     


Val Phe Val Leu Pro Leu Leu 
            180             


<210>  8229
<211>  183
<212>  PRT
<213>  Homo Sapiens

<400>  8229

Met Leu Tyr Lys Ser Ser Asp Arg Pro Ala His Lys Val Ser Met Leu 
1               5                   10                  15      


Leu Leu Cys His Ala Leu Ala Ile Ala Val Val Gln Ile Val Ile Phe 
            20                  25                  30          


Ser Glu Ser Trp Ala Phe Ala Lys Asn Ile Asn Phe Tyr Asn Val Arg 
        35                  40                  45              


Pro Pro Leu Asp Pro Thr Pro Phe Pro Asn Ser Phe Lys Cys Phe Thr 
    50                  55                  60                  


Cys Glu Asn Ala Gly Asp Asn Tyr Asn Cys Asn Arg Trp Ala Glu Asp 
65                  70                  75                  80  


Lys Trp Cys Pro Gln Asn Thr Gln Tyr Cys Leu Thr Val His His Phe 
                85                  90                  95      


Thr Ser His Gly Arg Ser Thr Ser Ile Thr Lys Lys Cys Ala Ser Arg 
            100                 105                 110         


Ser Glu Cys His Phe Val Gly Cys His His Ser Arg Asp Ser Glu His 
        115                 120                 125             


Thr Glu Cys Arg Ser Cys Cys Glu Gly Met Ile Cys Asn Val Glu Leu 
    130                 135                 140                 


Pro Thr Asn His Thr Asn Ala Val Phe Ala Val Met His Ala Gln Arg 
145                 150                 155                 160 


Thr Ser Gly Ser Ser Ala Pro Thr Leu Tyr Leu Pro Val Leu Ala Trp 
                165                 170                 175     


Val Phe Val Leu Pro Leu Leu 
            180             


<210>  8230
<211>  183
<212>  PRT
<213>  Homo Sapiens

<400>  8230

Met Arg Tyr Lys Ser Ser Asp Arg Pro Ala His Lys Val Ser Met Leu 
1               5                   10                  15      


Leu Leu Cys His Ala Leu Ala Ile Ala Val Val Gln Ile Val Ile Phe 
            20                  25                  30          


Ser Glu Ser Trp Ala Phe Ala Lys Asn Ile Asn Phe Tyr Asn Val Arg 
        35                  40                  45              


Pro Pro Leu Asp Pro Thr Pro Phe Pro Asn Ser Phe Lys Cys Phe Thr 
    50                  55                  60                  


Cys Glu Asn Ala Gly Asp Asn Tyr Asn Cys Asn Arg Trp Ala Glu Asp 
65                  70                  75                  80  


Lys Trp Cys Pro Gln Asn Thr Gln Tyr Cys Leu Thr Val His His Phe 
                85                  90                  95      


Thr Ser His Gly Arg Ser Thr Ser Ile Thr Lys Lys Cys Ala Ser Arg 
            100                 105                 110         


Ser Glu Cys His Phe Val Gly Cys His His Ser Arg Asp Ser Glu His 
        115                 120                 125             


Thr Glu Cys Arg Ser Cys Cys Glu Gly Met Ile Cys Asn Val Glu Leu 
    130                 135                 140                 


Pro Thr Asn His Thr Asn Ala Val Phe Ala Val Met His Ala Gln Arg 
145                 150                 155                 160 


Thr Ser Gly Ser Ser Ala Pro Thr Leu Tyr Leu Pro Val Leu Ala Trp 
                165                 170                 175     


Val Phe Val Leu Pro Leu Leu 
            180             


<210>  8231
<211>  237
<212>  PRT
<213>  Homo Sapiens

<400>  8231

Met Lys Gly Ile Leu Val Ala Gly Ile Thr Ala Val Leu Val Ala Ala 
1               5                   10                  15      


Val Glu Ser Leu Ser Cys Val Gln Cys Asn Ser Trp Glu Lys Ser Cys 
            20                  25                  30          


Val Asn Ser Ile Ala Ser Glu Cys Pro Ser His Ala Asn Thr Ser Cys 
        35                  40                  45              


Ile Ser Ser Ser Ala Ser Ser Ser Leu Glu Thr Pro Val Arg Leu Tyr 
    50                  55                  60                  


Gln Asn Met Phe Cys Ser Ala Glu Asn Cys Ser Glu Glu Thr His Ile 
65                  70                  75                  80  


Thr Ala Phe Thr Val His Val Ser Ala Glu Glu His Phe His Phe Val 
                85                  90                  95      


Ser Gln Cys Cys Gln Gly Lys Glu Cys Ser Asn Thr Ser Asp Ala Leu 
            100                 105                 110         


Asp Pro Pro Leu Lys Asn Val Ser Ser Asn Ala Glu Cys Pro Ala Cys 
        115                 120                 125             


Tyr Glu Ser Asn Gly Thr Ser Cys His Gly Lys Pro Trp Lys Cys Tyr 
    130                 135                 140                 


Glu Glu Glu Gln Cys Val Phe Leu Val Ala Glu Leu Lys Asn Asp Ile 
145                 150                 155                 160 


Glu Ser Lys Ser Leu Val Leu Lys Gly Cys Ser Asn Val Ser Asn Ala 
                165                 170                 175     


Thr Cys Gln Phe Leu Ser Gly Glu Asn Lys Thr Leu Gly Gly Val Ile 
            180                 185                 190         


Phe Arg Lys Phe Glu Cys Ala Asn Val Asn Ser Leu Thr Pro Thr Ser 
        195                 200                 205             


Ala Pro Thr Thr Ser His Asn Val Gly Ser Lys Ala Ser Leu Tyr Leu 
    210                 215                 220                 


Leu Ala Leu Ala Ser Leu Leu Leu Arg Gly Leu Leu Pro 
225                 230                 235         


<210>  8232
<211>  54
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8232

Xaa Pro Pro Leu Lys Asn Val Ser Ser Asn Ala Glu Cys Pro Ala Cys 
1               5                   10                  15      


Tyr Glu Ser Asn Gly Thr Ser Cys His Gly Lys Pro Trp Lys Cys Tyr 
            20                  25                  30          


Glu Glu Glu Gln Cys Val Phe Leu Val Ala Glu Leu Lys Asn Gly Thr 
        35                  40                  45              


Pro Gly Asp Gly Ala Asp 
    50                  


<210>  8233
<211>  148
<212>  PRT
<213>  Homo Sapiens

<400>  8233

Met Lys Ala Leu Ile Val Leu Gly Leu Val Leu Leu Ser Val Thr Val 
1               5                   10                  15      


Gln Gly Lys Val Phe Glu Arg Cys Glu Leu Ala Arg Thr Leu Lys Arg 
            20                  25                  30          


Leu Gly Met Asp Gly Tyr Arg Gly Ile Ser Leu Ala Asn Trp Met Cys 
        35                  40                  45              


Leu Ala Lys Trp Glu Ser Gly Tyr Asn Thr Arg Ala Thr Asn Tyr Asn 
    50                  55                  60                  


Ala Gly Asp Arg Ser Thr Asp Tyr Gly Ile Phe Gln Ile Asn Ser Arg 
65                  70                  75                  80  


Tyr Trp Cys Asn Asp Gly Lys Thr Pro Gly Ala Val Asn Ala Cys His 
                85                  90                  95      


Leu Ser Cys Ser Ala Leu Leu Gln Asp Asn Ile Ala Asp Ala Val Ala 
            100                 105                 110         


Cys Ala Lys Arg Val Val Arg Asp Pro Gln Gly Ile Arg Ala Trp Val 
        115                 120                 125             


Ala Trp Arg Asn Arg Cys Gln Asn Arg Asp Val Arg Gln Tyr Val Gln 
    130                 135                 140                 


Gly Cys Gly Val 
145             


<210>  8234
<211>  104
<212>  PRT
<213>  Homo Sapiens

<400>  8234

Met Lys Ala Leu Ile Val Leu Gly Leu Val Leu Leu Ser Val Thr Val 
1               5                   10                  15      


Gln Gly Lys Val Phe Glu Arg Cys Glu Leu Ala Arg Thr Leu Lys Arg 
            20                  25                  30          


Leu Gly Met Asp Gly Tyr Arg Gly Ile Ser Leu Ala Asn Trp Met Cys 
        35                  40                  45              


Leu Ala Lys Trp Glu Ser Gly Tyr Asn Thr Arg Ala Thr Asn Tyr Asn 
    50                  55                  60                  


Ala Gly Asp Arg Ser Thr Asp Tyr Gly Ile Phe Gln Ile Asn Ser Arg 
65                  70                  75                  80  


Tyr Trp Cys Asn Asp Gly Lys Thr Pro Gly Ala Val Asn Ala Cys His 
                85                  90                  95      


Leu Ser Cys Ser Gly Lys Thr Ser 
            100                 


<210>  8235
<211>  137
<212>  PRT
<213>  Homo Sapiens

<400>  8235

Met Lys Ala Leu Ile Val Leu Gly Leu Val Leu Leu Ser Val Thr Val 
1               5                   10                  15      


Gln Gly Lys Val Phe Glu Arg Cys Glu Leu Ala Arg Thr Leu Lys Arg 
            20                  25                  30          


Leu Gly Met Asp Gly Tyr Arg Gly Ile Ser Leu Ala Asn Trp Met Cys 
        35                  40                  45              


Leu Ala Lys Trp Glu Ser Gly Tyr Asn Thr Arg Ala Thr Asn Tyr Asn 
    50                  55                  60                  


Ala Gly Asp Arg Ser Thr Asp Tyr Gly Ile Phe Gln Ile Asn Ser Arg 
65                  70                  75                  80  


Tyr Trp Cys Asn Asp Gly Lys Thr Pro Gly Ala Val Asn Ala Cys His 
                85                  90                  95      


Leu Ser Cys Ser Gly Trp His Gly Glu Ile Val Val Lys Thr Glu Met 
            100                 105                 110         


Ser Val Ser Met Phe Lys Val Val Glu Cys Asn Ser Arg Ile Phe Leu 
        115                 120                 125             


Leu Gln Leu Ile Leu Ser Leu Ser His 
    130                 135         


<210>  8236
<211>  146
<212>  PRT
<213>  Homo Sapiens

<400>  8236

Met Lys Ala Ser Val Val Leu Ser Leu Leu Gly Tyr Leu Val Val Pro 
1               5                   10                  15      


Ser Gly Ala Tyr Ile Leu Gly Arg Cys Thr Val Ala Lys Lys Leu His 
            20                  25                  30          


Asp Gly Gly Leu Asp Tyr Phe Glu Gly Tyr Ser Leu Glu Asn Trp Val 
        35                  40                  45              


Cys Leu Ala Tyr Phe Glu Ser Lys Phe Asn Pro Met Ala Ile Tyr Glu 
    50                  55                  60                  


Asn Thr Arg Glu Gly Tyr Thr Gly Phe Gly Leu Phe Gln Met Arg Gly 
65                  70                  75                  80  


Ser Asp Trp Cys Gly Asp His Gly Arg Asn Arg Cys His Met Ser Cys 
                85                  90                  95      


Ser Ala Leu Leu Asn Pro Asn Leu Glu Lys Thr Ile Lys Cys Ala Lys 
            100                 105                 110         


Thr Ile Val Lys Gly Lys Glu Gly Met Gly Ala Trp Pro Thr Trp Ser 
        115                 120                 125             


Arg Tyr Cys Gln Tyr Ser Asp Thr Leu Ala Arg Trp Leu Asp Gly Cys 
    130                 135                 140                 


Lys Leu 
145     


<210>  8237
<211>  146
<212>  PRT
<213>  Homo Sapiens

<400>  8237

Met Lys Ala Ser Val Val Leu Ser Leu Leu Gly Tyr Leu Val Val Pro 
1               5                   10                  15      


Ser Gly Ala Tyr Ile Leu Gly Arg Cys Thr Val Ala Lys Lys Leu His 
            20                  25                  30          


Asp Gly Gly Leu Asp Tyr Phe Glu Gly Tyr Ser Leu Glu Asn Trp Val 
        35                  40                  45              


Cys Leu Ala Tyr Phe Glu Ser Lys Phe Asn Pro Met Ala Ile Tyr Glu 
    50                  55                  60                  


Asn Thr Arg Glu Gly Tyr Thr Gly Phe Gly Leu Phe Gln Met Arg Gly 
65                  70                  75                  80  


Ser Asp Trp Cys Gly Asp His Gly Arg Asn Arg Cys His Met Ser Cys 
                85                  90                  95      


Ser Ala Leu Leu Asn Pro Asn Leu Glu Lys Thr Ile Lys Cys Ala Lys 
            100                 105                 110         


Thr Ile Val Lys Gly Lys Glu Gly Met Gly Ala Trp Pro Thr Trp Ser 
        115                 120                 125             


Arg Tyr Cys Gln Tyr Ser Asp Thr Leu Ala Arg Trp Leu Asp Gly Cys 
    130                 135                 140                 


Lys Leu 
145     


<210>  8238
<211>  148
<212>  PRT
<213>  Homo Sapiens

<400>  8238

Met Thr Lys Ala Leu Leu Ile Tyr Leu Val Ser Ser Phe Leu Ala Leu 
1               5                   10                  15      


Asn Gln Ala Ser Leu Ile Ser Arg Cys Asp Leu Ala Gln Val Leu Gln 
            20                  25                  30          


Leu Glu Asp Leu Asp Gly Phe Glu Gly Tyr Ser Leu Ser Asp Trp Leu 
        35                  40                  45              


Cys Leu Ala Phe Val Glu Ser Lys Phe Asn Ile Ser Lys Ile Asn Glu 
    50                  55                  60                  


Asn Ala Asp Gly Ser Phe Asp Tyr Gly Leu Phe Gln Ile Asn Ser His 
65                  70                  75                  80  


Tyr Trp Cys Asn Asp Tyr Lys Ser Tyr Ser Glu Asn Leu Cys His Val 
                85                  90                  95      


Asp Cys Gln Asp Leu Leu Asn Pro Asn Leu Leu Ala Gly Ile His Cys 
            100                 105                 110         


Ala Lys Arg Ile Val Ser Gly Ala Arg Gly Met Asn Asn Trp Val Glu 
        115                 120                 125             


Trp Arg Leu His Cys Ser Gly Arg Pro Leu Phe Tyr Trp Leu Thr Gly 
    130                 135                 140                 


Cys Arg Leu Arg 
145             


<210>  8239
<211>  148
<212>  PRT
<213>  Homo Sapiens

<400>  8239

Met Thr Lys Ala Leu Leu Ile Tyr Leu Val Ser Ser Phe Leu Ala Leu 
1               5                   10                  15      


Asn Gln Ala Ser Leu Ile Ser Arg Cys Asp Leu Ala Gln Val Leu Gln 
            20                  25                  30          


Leu Glu Asp Leu Asp Gly Phe Glu Gly Tyr Ser Leu Ser Asp Trp Leu 
        35                  40                  45              


Cys Leu Ala Phe Val Glu Ser Lys Phe Asn Ile Ser Lys Ile Asn Glu 
    50                  55                  60                  


Asn Ala Asp Gly Ser Phe Asp Tyr Gly Leu Phe Gln Ile Asn Ser His 
65                  70                  75                  80  


Tyr Trp Cys Asn Asp Tyr Lys Ser Tyr Ser Glu Asn Leu Cys His Val 
                85                  90                  95      


Asp Cys Gln Asp Leu Leu Asn Pro Asn Leu Leu Ala Gly Ile His Cys 
            100                 105                 110         


Ala Lys Arg Ile Val Ser Gly Ala Arg Gly Met Asn Asn Trp Val Glu 
        115                 120                 125             


Trp Arg Leu His Cys Ser Gly Arg Pro Leu Phe Tyr Trp Leu Thr Gly 
    130                 135                 140                 


Cys Arg Leu Arg 
145             


<210>  8240
<211>  86
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8240

Xaa Leu Glu Asp Leu Asp Gly Phe Glu Gly Tyr Ser Leu Ser Asp Trp 
1               5                   10                  15      


Leu Cys Leu Ala Phe Val Glu Ser Lys Phe Asn Ile Ser Lys Ile Asn 
            20                  25                  30          


Glu Asn Ala Asp Gly Ser Phe Asp Tyr Gly Leu Phe Gln Ile Asn Ser 
        35                  40                  45              


His Tyr Trp Cys Asn Asp Tyr Lys Ser Tyr Ser Glu Asn Leu Cys His 
    50                  55                  60                  


Val Asp Cys Gln Gly Ile His Cys Ala Lys Arg Ile Val Ser Gly Ala 
65                  70                  75                  80  


Arg Gly Met Asn Asn Trp 
                85      


<210>  8241
<211>  148
<212>  PRT
<213>  Homo Sapiens

<400>  8241

Leu Leu Leu Leu Leu Ala Val Ala Val Arg Glu Ser Trp Gln Thr Glu 
1               5                   10                  15      


Glu Lys Thr Cys Asp Leu Asp Asn Phe Asn Pro Val Ser Glu Glu Arg 
            20                  25                  30          


Gly Lys Val Gln Asp Cys Phe Tyr Leu Phe Glu Met Asp Ser Ser Leu 
        35                  40                  45              


Ala Cys Ser Pro Glu Ile Ser His Leu Ser Val Gly Ser Ile Leu Leu 
    50                  55                  60                  


Val Thr Phe Ala Ser Leu Val Ala Val Tyr Val Val Gly Gly Phe Leu 
65                  70                  75                  80  


Tyr Gln Arg Leu Val Val Gly Ala Lys Gly Met Glu Gln Phe Pro His 
                85                  90                  95      


Leu Ala Phe Trp Gln Asp Leu Gly Asn Leu Val Ala Asp Gly Cys Asp 
            100                 105                 110         


Phe Val Cys Arg Ser Lys Pro Arg Asn Val Pro Ala Ala Tyr Arg Gly 
        115                 120                 125             


Val Gly Asp Asp Gln Leu Gly Glu Glu Ser Glu Glu Arg Asp Asp His 
    130                 135                 140                 


Leu Leu Pro Met 
145             


<210>  8242
<211>  92
<212>  PRT
<213>  Homo Sapiens

<400>  8242

Met Phe Pro Phe Tyr Ser Cys Trp Arg Thr Gly Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ala Val Ala Val Arg Glu Ser Trp Gln Thr Glu Glu Lys Thr Cys 
            20                  25                  30          


Asp Leu Val Gly Glu Lys Gly Lys Glu Ser Glu Lys Glu Leu Ala Leu 
        35                  40                  45              


Val Lys Arg Leu Lys Pro Leu Phe Asn Lys Ser Phe Glu Ser Thr Val 
    50                  55                  60                  


Gly Gln Gly Ser Asp Thr Tyr Ile Tyr Ile Phe Arg Val Cys Arg Glu 
65                  70                  75                  80  


Ala Gly Asn His Thr Ser Gly Ala Gly Leu Val Gln 
                85                  90          


<210>  8243
<211>  109
<212>  PRT
<213>  Homo Sapiens

<400>  8243

Met Phe Pro Phe Tyr Ser Cys Trp Arg Thr Gly Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ala Val Ala Val Arg Glu Ser Trp Gln Thr Glu Glu Lys Thr Cys 
            20                  25                  30          


Asp Leu Val Gly Glu Lys Gly Lys Glu Ser Glu Lys Glu Leu Ala Leu 
        35                  40                  45              


Val Lys Arg Leu Lys Pro Leu Phe Asn Lys Ser Phe Glu Ser Thr Val 
    50                  55                  60                  


Gly Gln Gly Ser Asp Thr Tyr Ile Tyr Ile Phe Arg Val Cys Arg Glu 
65                  70                  75                  80  


Ala Gly Asn His Thr Ser Gly Ala Gly Leu Val Gln Ile Asn Lys Ser 
                85                  90                  95      


Asn Gly Lys Glu Thr Val Val Gly Arg Leu Asn Glu Thr 
            100                 105                 


<210>  8244
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  8244

Met Phe Pro Phe Tyr Ser Cys Trp Arg Thr Gly Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ala Val Ala Val Arg Glu Ser Trp Gln Thr Glu Glu Lys Thr Cys 
            20                  25                  30          


Asp Leu Val Gly Glu Lys Gly Lys Glu Ser Glu Lys Glu Leu Ala Leu 
        35                  40                  45              


Val Lys Arg Leu Lys Pro Leu Phe Asn Lys Ser Phe Glu Ser Thr Val 
    50                  55                  60                  


Gly Gln Gly Ser Asp Thr Tyr Ile Tyr Ile Phe Arg Val Cys Arg Glu 
65                  70                  75                  80  


Ala Gly Asn His Thr Ser Gly Ala Gly Leu Val Gln Ile Asn Lys Ser 
                85                  90                  95      


Asn Gly Lys Glu Thr Val Val Gly Arg Leu Asn Glu Thr His Ile Phe 
            100                 105                 110         


Asn Gly Ser Leu His His Trp Leu Leu Phe Met Leu Leu Gly Gly Ser 
        115                 120                 125             


Tyr Thr Ser Asp Trp 
    130             


<210>  8245
<211>  191
<212>  PRT
<213>  Homo Sapiens

<400>  8245

Met Phe Pro Phe Tyr Ser Cys Trp Arg Thr Gly Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ala Val Ala Val Arg Glu Ser Trp Gln Thr Glu Glu Lys Thr Cys 
            20                  25                  30          


Asp Leu Val Gly Glu Lys Gly Lys Glu Ser Glu Lys Glu Leu Ala Leu 
        35                  40                  45              


Val Lys Arg Leu Lys Pro Leu Phe Asn Lys Ser Phe Glu Ser Thr Val 
    50                  55                  60                  


Gly Gln Gly Ser Asp Thr Tyr Ile Tyr Ile Phe Arg Val Cys Arg Glu 
65                  70                  75                  80  


Ala Gly Asn His Thr Ser Gly Ala Gly Leu Val Gln Ile Asn Lys Ser 
                85                  90                  95      


Asn Gly Lys Glu Thr Val Val Gly Arg Leu Asn Glu Thr His Ile Phe 
            100                 105                 110         


Asn Gly Ser Asn Trp Ile Met Leu Ile Tyr Lys Gly Gly Asp Glu Tyr 
        115                 120                 125             


Asp Asn His Cys Gly Lys Glu Gln Arg Arg Ala Val Val Met Ile Ser 
    130                 135                 140                 


Cys Asn Arg His Thr Leu Ala Asp Gly Cys Asp Phe Val Cys Arg Ser 
145                 150                 155                 160 


Lys Pro Arg Asn Val Pro Ala Ala Tyr Arg Gly Val Gly Asp Asp Gln 
                165                 170                 175     


Leu Gly Glu Glu Ser Glu Glu Arg Asp Asp His Leu Leu Pro Met 
            180                 185                 190     


<210>  8246
<211>  277
<212>  PRT
<213>  Homo Sapiens

<400>  8246

Met Phe Pro Phe Tyr Ser Cys Trp Arg Thr Gly Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ala Val Ala Val Arg Glu Ser Trp Gln Thr Glu Glu Lys Thr Cys 
            20                  25                  30          


Asp Leu Val Gly Glu Lys Gly Lys Glu Ser Glu Lys Glu Leu Ala Leu 
        35                  40                  45              


Val Lys Arg Leu Lys Pro Leu Phe Asn Lys Ser Phe Glu Ser Thr Val 
    50                  55                  60                  


Gly Gln Gly Ser Asp Thr Tyr Ile Tyr Ile Phe Arg Val Cys Arg Glu 
65                  70                  75                  80  


Ala Gly Asn His Thr Ser Gly Ala Gly Leu Val Gln Ile Asn Lys Ser 
                85                  90                  95      


Asn Gly Lys Glu Thr Val Val Gly Arg Leu Asn Glu Thr His Ile Phe 
            100                 105                 110         


Asn Gly Ser Asn Trp Ile Met Leu Ile Tyr Lys Gly Gly Asp Glu Tyr 
        115                 120                 125             


Asp Asn His Cys Gly Lys Glu Gln Arg Arg Ala Val Val Met Ile Ser 
    130                 135                 140                 


Cys Asn Arg His Thr Leu Ala Asp Asn Phe Asn Pro Val Ser Glu Glu 
145                 150                 155                 160 


Arg Gly Lys Val Gln Asp Cys Phe Tyr Leu Phe Glu Met Asp Ser Ser 
                165                 170                 175     


Leu Ala Cys Ser Pro Glu Ile Ser His Leu Ser Val Gly Ser Ile Leu 
            180                 185                 190         


Leu Val Thr Phe Ala Ser Leu Val Ala Val Tyr Val Val Gly Gly Phe 
        195                 200                 205             


Leu Tyr Gln Arg Leu Val Val Gly Ala Lys Gly Met Glu Gln Phe Pro 
    210                 215                 220                 


His Leu Ala Phe Trp Gln Asp Leu Gly Asn Leu Val Ala Asp Gly Cys 
225                 230                 235                 240 


Asp Phe Val Cys Arg Ser Lys Pro Arg Asn Val Pro Ala Ala Tyr Arg 
                245                 250                 255     


Gly Val Gly Asp Asp Gln Leu Gly Glu Glu Ser Glu Glu Arg Asp Asp 
            260                 265                 270         


His Leu Leu Pro Met 
        275         


<210>  8247
<211>  25
<212>  PRT
<213>  Homo Sapiens

<400>  8247

Met Leu Ile Tyr Lys Gly Gly Asp Glu Tyr Asp Asn His Cys Gly Lys 
1               5                   10                  15      


Glu Gln Arg Arg Ala Val Val Met Ile 
            20                  25  


<210>  8248
<211>  85
<212>  PRT
<213>  Homo Sapiens

<400>  8248

Val Val Gly Gly Phe Leu Tyr Gln Arg Leu Val Val Gly Ala Lys Gly 
1               5                   10                  15      


Met Glu Gln Phe Pro His Leu Ala Phe Trp Gln Asp Leu Gly Asn Leu 
            20                  25                  30          


Val Ala Ala Cys Gly Phe Asp Leu Phe Phe Asn Leu Leu Glu Arg Glu 
        35                  40                  45              


Arg Lys Gln Lys Trp Asp Ile Glu Gly Ser Ala Val Leu Cys Ala Gly 
    50                  55                  60                  


Cys Gly Met Leu Leu His Leu Ser Leu Leu Leu Ala Gln Gly Ser Val 
65                  70                  75                  80  


Phe Leu Pro Thr Phe 
                85  


<210>  8249
<211>  104
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8249

Xaa Phe Asn Lys Ser Phe Glu Ser Thr Val Gly Gln Gly Ser Asp Thr 
1               5                   10                  15      


Tyr Ile Tyr Ile Phe Arg Val Cys Arg Glu Ala Gly Asn His Thr Ser 
            20                  25                  30          


Gly Ala Gly Leu Val Gln Ile Asn Lys Ser Asn Gly Lys Glu Thr Val 
        35                  40                  45              


Val Gly Arg Leu Asn Glu Thr His Ile Phe Asn Gly Ser Asn Trp Ile 
    50                  55                  60                  


Met Leu Ile Tyr Lys Gly Gly Asp Glu Tyr Asp Asn His Cys Gly Lys 
65                  70                  75                  80  


Glu Gln Arg Arg Ala Val Val Met Ile Ser Cys Asn Arg His Thr Leu 
                85                  90                  95      


Ala Glu Ser Lys His Leu Thr Thr 
            100                 


<210>  8250
<211>  122
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8250

Xaa Gly Gly Asp Glu Tyr Asp Asn His Cys Gly Lys Glu Gln Arg Arg 
1               5                   10                  15      


Ala Val Val Met Ile Ser Cys Asn Arg His Thr Leu Ala Asp Asn Phe 
            20                  25                  30          


Asn Pro Val Ser Glu Glu Arg Gly Lys Val Gln Asp Cys Phe Tyr Leu 
        35                  40                  45              


Phe Glu Met Asp Ser Ser Leu Ala Cys Ser Pro Glu Ile Ser His Leu 
    50                  55                  60                  


Ser Val Gly Ser Ile Leu Leu Val Thr Phe Ala Ser Leu Val Ala Val 
65                  70                  75                  80  


Tyr Val Val Gly Gly Phe Leu Tyr Gln Arg Leu Val Val Gly Ala Lys 
                85                  90                  95      


Gly Met Glu Gln Phe Pro His Leu Ala Phe Trp Gln Asp Leu Gly Asn 
            100                 105                 110         


Leu Val Ala Val Ser Asn Arg Ala Ala Gly 
        115                 120         


<210>  8251
<211>  96
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8251

Xaa Ile Leu Leu Val Thr Phe Ala Ser Leu Val Ala Val Tyr Val Val 
1               5                   10                  15      


Gly Gly Phe Leu Tyr Gln Arg Leu Val Val Gly Ala Lys Gly Met Glu 
            20                  25                  30          


Gln Phe Pro His Leu Ala Phe Trp Gln Asp Leu Gly Asn Leu Val Ala 
        35                  40                  45              


Lys Gly Asn Gly Ser Arg Ser Gly Thr Ser Arg Ala Leu Leu Ser Ser 
    50                  55                  60                  


Ala Leu Gly Val Glu Cys Cys Cys Thr Cys Pro Phe Cys Trp Leu Arg 
65                  70                  75                  80  


Glu Val Ser Ser Cys Pro His Phe Cys Gly Glu Arg Phe Leu Ile Leu 
                85                  90                  95      


<210>  8252
<211>  157
<212>  PRT
<213>  Homo Sapiens

<400>  8252

Met Glu Asp Leu Gly Glu Asn Thr Met Val Leu Ser Thr Leu Arg Ser 
1               5                   10                  15      


Leu Asn Asn Phe Ile Ser Gln Arg Val Glu Gly Gly Ser Gly Leu Asp 
            20                  25                  30          


Ile Ser Thr Ser Ala Pro Gly Ser Leu Gln Met Gln Tyr Gln Gln Ser 
        35                  40                  45              


Met Gln Leu Glu Glu Arg Ala Glu Gln Ile Arg Ser Lys Ser His Leu 
    50                  55                  60                  


Ile Gln Val Glu Arg Glu Lys Met Gln Met Glu Leu Ser His Lys Arg 
65                  70                  75                  80  


Ala Arg Val Glu Leu Glu Arg Ala Ala Ser Thr Ser Ala Arg Asn Tyr 
                85                  90                  95      


Glu Arg Glu Val Asp Arg Asn Gln Glu Leu Leu Thr Arg Ile Arg Gln 
            100                 105                 110         


Leu Gln Glu Arg Glu Ala Gly Ala Glu Glu Lys Met Gln Glu Gln Leu 
        115                 120                 125             


Glu Arg Asn Arg Gln Cys Gln Gln Asn Leu Asp Ala Ala Ser Lys Arg 
    130                 135                 140                 


Leu Arg Glu Lys Glu Asp Ser Leu Ala Gln Ala Gly Glu 
145                 150                 155         


<210>  8253
<211>  718
<212>  PRT
<213>  Homo Sapiens

<400>  8253

Met Glu Asp Leu Gly Glu Asn Thr Met Val Leu Ser Thr Leu Arg Ser 
1               5                   10                  15      


Leu Asn Asn Phe Ile Ser Gln Arg Val Glu Gly Gly Ser Gly Leu Asp 
            20                  25                  30          


Ile Ser Thr Ser Ala Pro Gly Ser Leu Gln Met Gln Tyr Gln Gln Ser 
        35                  40                  45              


Met Gln Leu Glu Glu Arg Ala Glu Gln Ile Arg Ser Lys Ser His Leu 
    50                  55                  60                  


Ile Gln Val Glu Arg Glu Lys Met Gln Met Glu Leu Ser His Lys Arg 
65                  70                  75                  80  


Ala Arg Val Glu Leu Glu Arg Ala Ala Ser Thr Ser Ala Arg Asn Tyr 
                85                  90                  95      


Glu Arg Glu Val Asp Arg Asn Gln Glu Leu Leu Thr Arg Ile Arg Gln 
            100                 105                 110         


Leu Gln Glu Arg Glu Ala Gly Ala Glu Glu Lys Met Gln Glu Gln Leu 
        115                 120                 125             


Glu Arg Asn Arg Gln Cys Gln Gln Asn Leu Asp Ala Ala Ser Lys Arg 
    130                 135                 140                 


Leu Arg Glu Lys Glu Asp Ser Leu Ala Gln Ala Gly Glu Thr Ile Asn 
145                 150                 155                 160 


Ala Leu Lys Gly Arg Ile Ser Glu Leu Gln Trp Ser Val Met Asp Gln 
                165                 170                 175     


Glu Met Arg Val Lys Arg Leu Glu Ser Glu Lys Gln Glu Leu Gln Glu 
            180                 185                 190         


Gln Leu Asp Leu Gln His Lys Lys Cys Gln Glu Ala Asn Gln Lys Ile 
        195                 200                 205             


Gln Glu Leu Gln Ala Ser Gln Glu Ala Arg Ala Asp His Glu Gln Gln 
    210                 215                 220                 


Ile Lys Asp Leu Glu Gln Lys Leu Ser Leu Gln Glu Gln Asp Ala Ala 
225                 230                 235                 240 


Ile Val Lys Asn Met Lys Ser Glu Leu Val Arg Leu Pro Arg Leu Glu 
                245                 250                 255     


Arg Glu Leu Lys Gln Leu Arg Glu Glu Ser Ala His Leu Arg Glu Met 
            260                 265                 270         


Arg Glu Thr Asn Gly Leu Leu Gln Glu Glu Leu Glu Gly Leu Gln Arg 
        275                 280                 285             


Lys Leu Gly Arg Gln Glu Lys Met Gln Glu Thr Leu Val Gly Leu Glu 
    290                 295                 300                 


Leu Glu Asn Glu Arg Leu Leu Ala Lys Leu Gln Ser Trp Glu Arg Leu 
305                 310                 315                 320 


Asp Gln Thr Met Gly Leu Ser Ile Arg Thr Pro Glu Asp Leu Ser Arg 
                325                 330                 335     


Phe Val Val Glu Leu Gln Gln Arg Glu Leu Ala Leu Lys Asp Lys Asn 
            340                 345                 350         


Ser Ala Val Thr Ser Ser Ala Arg Gly Leu Glu Lys Ala Arg Gln Gln 
        355                 360                 365             


Leu Gln Glu Glu Leu Arg Gln Val Ser Gly Gln Leu Leu Glu Glu Arg 
    370                 375                 380                 


Lys Lys Arg Glu Thr His Glu Ala Leu Ala Arg Arg Leu Gln Lys Arg 
385                 390                 395                 400 


Val Leu Leu Leu Thr Lys Glu Arg Asp Gly Met Arg Ala Ile Leu Gly 
                405                 410                 415     


Ser Tyr Asp Ser Glu Leu Thr Pro Ala Glu Tyr Ser Pro Gln Leu Thr 
            420                 425                 430         


Arg Arg Met Arg Glu Ala Glu Asp Met Val Gln Lys Val His Ser His 
        435                 440                 445             


Ser Ala Glu Met Glu Ala Gln Leu Ser Gln Ala Leu Glu Glu Leu Gly 
    450                 455                 460                 


Gly Gln Lys Gln Arg Ala Asp Met Leu Glu Met Glu Leu Lys Met Leu 
465                 470                 475                 480 


Lys Ser Gln Ser Ser Ser Ala Glu Gln Ser Phe Leu Phe Ser Arg Glu 
                485                 490                 495     


Glu Ala Asp Thr Leu Arg Leu Lys Val Glu Glu Leu Glu Gly Glu Arg 
            500                 505                 510         


Ser Arg Leu Glu Glu Glu Lys Arg Met Leu Glu Ala Gln Leu Glu Arg 
        515                 520                 525             


Arg Ala Leu Gln Gly Asp Tyr Asp Gln Ser Arg Thr Lys Val Leu His 
    530                 535                 540                 


Met Ser Leu Asn Pro Thr Ser Val Ala Arg Gln Arg Leu Arg Glu Asp 
545                 550                 555                 560 


His Ser Gln Leu Gln Ala Glu Cys Glu Arg Leu Arg Gly Leu Leu Arg 
                565                 570                 575     


Ala Met Glu Arg Gly Gly Thr Val Pro Ala Asp Leu Glu Ala Ala Ala 
            580                 585                 590         


Ala Ser Leu Pro Ser Ser Lys Glu Val Ala Glu Leu Lys Lys Gln Val 
        595                 600                 605             


Glu Ser Ala Glu Leu Lys Asn Gln Arg Leu Lys Glu Val Phe Gln Thr 
    610                 615                 620                 


Lys Ile Gln Glu Phe Arg Lys Ala Cys Tyr Thr Leu Thr Gly Tyr Gln 
625                 630                 635                 640 


Ile Asp Ile Thr Thr Glu Asn Gln Tyr Arg Leu Thr Ser Leu Tyr Ala 
                645                 650                 655     


Glu His Pro Gly Asp Cys Leu Ile Phe Lys Ala Thr Ser Pro Ser Gly 
            660                 665                 670         


Ser Lys Met Gln Leu Leu Glu Thr Glu Phe Ser His Thr Val Gly Glu 
        675                 680                 685             


Leu Ile Glu Val His Leu Arg Arg Gln Asp Ser Ile Pro Ala Phe Leu 
    690                 695                 700                 


Ser Ser Leu Thr Leu Glu Leu Phe Ser Arg Gln Thr Val Ala 
705                 710                 715             


<210>  8254
<211>  718
<212>  PRT
<213>  Homo Sapiens

<400>  8254

Met Glu Asp Leu Gly Glu Asn Thr Met Val Leu Ser Thr Leu Arg Ser 
1               5                   10                  15      


Leu Asn Asn Phe Ile Ser Gln Arg Val Glu Gly Gly Ser Gly Leu Asp 
            20                  25                  30          


Ile Ser Thr Ser Ala Pro Gly Ser Leu Gln Met Gln Tyr Gln Gln Ser 
        35                  40                  45              


Met Gln Leu Glu Glu Arg Ala Glu Gln Ile Arg Ser Lys Ser His Leu 
    50                  55                  60                  


Ile Gln Val Glu Arg Glu Lys Met Gln Met Glu Leu Ser His Lys Arg 
65                  70                  75                  80  


Ala Arg Val Glu Leu Glu Arg Ala Ala Ser Thr Ser Ala Arg Asn Tyr 
                85                  90                  95      


Glu Arg Glu Val Asp Arg Asn Gln Glu Leu Leu Thr Arg Ile Arg Gln 
            100                 105                 110         


Leu Gln Glu Arg Glu Ala Gly Ala Glu Glu Lys Met Gln Glu Gln Leu 
        115                 120                 125             


Glu Arg Asn Arg Gln Cys Gln Gln Asn Leu Asp Ala Ala Ser Lys Arg 
    130                 135                 140                 


Leu Arg Glu Lys Glu Asp Ser Leu Ala Gln Ala Gly Glu Thr Ile Asn 
145                 150                 155                 160 


Ala Leu Lys Gly Arg Ile Ser Glu Leu Gln Trp Ser Val Met Asp Gln 
                165                 170                 175     


Glu Met Arg Val Lys Arg Leu Glu Ser Glu Lys Gln Glu Leu Gln Glu 
            180                 185                 190         


Gln Leu Asp Leu Gln His Lys Lys Cys Gln Glu Ala Asn Gln Lys Ile 
        195                 200                 205             


Gln Glu Leu Gln Ala Ser Gln Glu Ala Arg Ala Asp His Glu Gln Gln 
    210                 215                 220                 


Ile Lys Asp Leu Glu Gln Lys Leu Ser Leu Gln Glu Gln Asp Ala Ala 
225                 230                 235                 240 


Ile Val Lys Asn Met Lys Ser Glu Leu Val Arg Leu Pro Arg Leu Glu 
                245                 250                 255     


Arg Glu Leu Lys Gln Leu Arg Glu Glu Ser Ala His Leu Arg Glu Met 
            260                 265                 270         


Arg Glu Thr Asn Gly Leu Leu Gln Glu Glu Leu Glu Gly Leu Gln Arg 
        275                 280                 285             


Lys Leu Gly Arg Gln Glu Lys Met Gln Glu Thr Leu Val Gly Leu Glu 
    290                 295                 300                 


Leu Glu Asn Glu Arg Leu Leu Ala Lys Leu Gln Ser Trp Glu Arg Leu 
305                 310                 315                 320 


Asp Gln Thr Met Gly Leu Ser Ile Arg Thr Pro Glu Asp Leu Ser Arg 
                325                 330                 335     


Phe Val Val Glu Leu Gln Gln Arg Glu Leu Ala Leu Lys Asp Lys Asn 
            340                 345                 350         


Ser Ala Val Thr Ser Ser Ala Arg Gly Leu Glu Lys Ala Arg Gln Gln 
        355                 360                 365             


Leu Gln Glu Glu Leu Arg Gln Val Ser Gly Gln Leu Leu Glu Glu Arg 
    370                 375                 380                 


Lys Lys Arg Glu Thr His Glu Ala Leu Ala Arg Arg Leu Gln Lys Arg 
385                 390                 395                 400 


Val Leu Leu Leu Thr Lys Glu Arg Asp Gly Met Arg Ala Ile Leu Gly 
                405                 410                 415     


Ser Tyr Asp Ser Glu Leu Thr Pro Ala Glu Tyr Ser Pro Gln Leu Thr 
            420                 425                 430         


Arg Arg Met Arg Glu Ala Glu Asp Met Val Gln Lys Val His Ser His 
        435                 440                 445             


Ser Ala Glu Met Glu Ala Gln Leu Ser Gln Ala Leu Glu Glu Leu Gly 
    450                 455                 460                 


Gly Gln Lys Gln Arg Ala Asp Met Leu Glu Met Glu Leu Lys Met Leu 
465                 470                 475                 480 


Lys Ser Gln Ser Ser Ser Ala Glu Gln Ser Phe Leu Phe Ser Arg Glu 
                485                 490                 495     


Glu Ala Asp Thr Leu Arg Leu Lys Val Glu Glu Leu Glu Gly Glu Arg 
            500                 505                 510         


Ser Arg Leu Glu Glu Glu Lys Arg Met Leu Glu Ala Gln Leu Glu Arg 
        515                 520                 525             


Arg Ala Leu Gln Gly Asp Tyr Asp Gln Ser Arg Thr Lys Val Leu His 
    530                 535                 540                 


Met Ser Leu Asn Pro Thr Ser Val Ala Arg Gln Arg Leu Arg Glu Asp 
545                 550                 555                 560 


His Ser Gln Leu Gln Ala Glu Cys Glu Arg Leu Arg Gly Leu Leu Arg 
                565                 570                 575     


Ala Met Glu Arg Gly Gly Thr Val Pro Ala Asp Leu Glu Ala Ala Ala 
            580                 585                 590         


Ala Ser Leu Pro Ser Ser Lys Glu Val Ala Glu Leu Lys Lys Gln Val 
        595                 600                 605             


Glu Ser Ala Glu Leu Lys Asn Gln Arg Leu Lys Glu Val Phe Gln Thr 
    610                 615                 620                 


Lys Ile Gln Glu Phe Arg Lys Ala Cys Tyr Thr Leu Thr Gly Tyr Gln 
625                 630                 635                 640 


Ile Asp Ile Thr Thr Glu Asn Gln Tyr Arg Leu Thr Ser Leu Tyr Ala 
                645                 650                 655     


Glu His Pro Gly Asp Cys Leu Ile Phe Lys Ala Thr Ser Pro Ser Gly 
            660                 665                 670         


Ser Lys Met Gln Leu Leu Glu Thr Glu Phe Ser His Thr Val Gly Glu 
        675                 680                 685             


Leu Ile Glu Val His Leu Arg Arg Gln Asp Ser Ile Pro Ala Phe Leu 
    690                 695                 700                 


Ser Ser Leu Thr Leu Glu Leu Phe Ser Arg Gln Thr Val Ala 
705                 710                 715             


<210>  8255
<211>  718
<212>  PRT
<213>  Homo Sapiens

<400>  8255

Met Glu Asp Leu Gly Glu Asn Thr Met Val Leu Ser Thr Leu Arg Ser 
1               5                   10                  15      


Leu Asn Asn Phe Ile Ser Gln Arg Val Glu Gly Gly Ser Gly Leu Asp 
            20                  25                  30          


Ile Ser Thr Ser Ala Pro Gly Ser Leu Gln Met Gln Tyr Gln Gln Ser 
        35                  40                  45              


Met Gln Leu Glu Glu Arg Ala Glu Gln Ile Arg Ser Lys Ser His Leu 
    50                  55                  60                  


Ile Gln Val Glu Arg Glu Lys Met Gln Met Glu Leu Ser His Lys Arg 
65                  70                  75                  80  


Ala Arg Val Glu Leu Glu Arg Ala Ala Ser Thr Ser Ala Arg Asn Tyr 
                85                  90                  95      


Glu Arg Glu Val Asp Arg Asn Gln Glu Leu Leu Thr Arg Ile Arg Gln 
            100                 105                 110         


Leu Gln Glu Arg Glu Ala Gly Ala Glu Glu Lys Met Gln Glu Gln Leu 
        115                 120                 125             


Glu Arg Asn Arg Gln Cys Gln Gln Asn Leu Asp Ala Ala Ser Lys Arg 
    130                 135                 140                 


Leu Arg Glu Lys Glu Asp Ser Leu Ala Gln Ala Gly Glu Thr Ile Asn 
145                 150                 155                 160 


Ala Leu Lys Gly Arg Ile Ser Glu Leu Gln Trp Ser Val Met Asp Gln 
                165                 170                 175     


Glu Met Arg Val Lys Arg Leu Glu Ser Glu Lys Gln Glu Leu Gln Glu 
            180                 185                 190         


Gln Leu Asp Leu Gln His Lys Lys Cys Gln Glu Ala Asn Gln Lys Ile 
        195                 200                 205             


Gln Glu Leu Gln Ala Ser Gln Glu Ala Arg Ala Asp His Glu Gln Gln 
    210                 215                 220                 


Ile Lys Asp Leu Glu Gln Lys Leu Ser Leu Gln Glu Gln Asp Ala Ala 
225                 230                 235                 240 


Ile Val Lys Asn Met Lys Ser Glu Leu Val Arg Leu Pro Arg Leu Glu 
                245                 250                 255     


Arg Glu Leu Lys Gln Leu Arg Glu Glu Ser Ala His Leu Arg Glu Met 
            260                 265                 270         


Arg Glu Thr Asn Gly Leu Leu Gln Glu Glu Leu Glu Gly Leu Gln Arg 
        275                 280                 285             


Lys Leu Gly Arg Gln Glu Lys Met Gln Glu Thr Leu Val Gly Leu Glu 
    290                 295                 300                 


Leu Glu Asn Glu Arg Leu Leu Ala Lys Leu Gln Ser Trp Glu Arg Leu 
305                 310                 315                 320 


Asp Gln Thr Met Gly Leu Ser Ile Arg Thr Pro Glu Asp Leu Ser Arg 
                325                 330                 335     


Phe Val Val Glu Leu Gln Gln Arg Glu Leu Ala Leu Lys Asp Lys Asn 
            340                 345                 350         


Ser Ala Val Thr Ser Ser Ala Arg Gly Leu Glu Lys Ala Arg Gln Gln 
        355                 360                 365             


Leu Gln Glu Glu Leu Arg Gln Val Ser Gly Gln Leu Leu Glu Glu Arg 
    370                 375                 380                 


Lys Lys Arg Glu Thr His Glu Ala Leu Ala Arg Arg Leu Gln Lys Arg 
385                 390                 395                 400 


Val Leu Leu Leu Thr Lys Glu Arg Asp Gly Met Arg Ala Ile Leu Gly 
                405                 410                 415     


Ser Tyr Asp Ser Glu Leu Thr Pro Ala Glu Tyr Ser Pro Gln Leu Thr 
            420                 425                 430         


Arg Arg Met Arg Glu Ala Glu Asp Met Val Gln Lys Val His Ser His 
        435                 440                 445             


Ser Ala Glu Met Glu Ala Gln Leu Ser Gln Ala Leu Glu Glu Leu Gly 
    450                 455                 460                 


Gly Gln Lys Gln Arg Ala Asp Met Leu Glu Met Glu Leu Lys Met Leu 
465                 470                 475                 480 


Lys Ser Gln Ser Ser Ser Ala Glu Gln Ser Phe Leu Phe Ser Arg Glu 
                485                 490                 495     


Glu Ala Asp Thr Leu Arg Leu Lys Val Glu Glu Leu Glu Gly Glu Arg 
            500                 505                 510         


Ser Arg Leu Glu Glu Glu Lys Arg Met Leu Glu Ala Gln Leu Glu Arg 
        515                 520                 525             


Arg Ala Leu Gln Gly Asp Tyr Asp Gln Ser Arg Thr Lys Val Leu His 
    530                 535                 540                 


Met Ser Leu Asn Pro Thr Ser Val Ala Arg Gln Arg Leu Arg Glu Asp 
545                 550                 555                 560 


His Ser Gln Leu Gln Ala Glu Cys Glu Arg Leu Arg Gly Leu Leu Arg 
                565                 570                 575     


Ala Met Glu Arg Gly Gly Thr Val Pro Ala Asp Leu Glu Ala Ala Ala 
            580                 585                 590         


Ala Ser Leu Pro Ser Ser Lys Glu Val Ala Glu Leu Lys Lys Gln Val 
        595                 600                 605             


Glu Ser Ala Glu Leu Lys Asn Gln Arg Leu Lys Glu Val Phe Gln Thr 
    610                 615                 620                 


Lys Ile Gln Glu Phe Arg Lys Ala Cys Tyr Thr Leu Thr Gly Tyr Gln 
625                 630                 635                 640 


Ile Asp Ile Thr Thr Glu Asn Gln Tyr Arg Leu Thr Ser Leu Tyr Ala 
                645                 650                 655     


Glu His Pro Gly Asp Cys Leu Ile Phe Lys Ala Thr Ser Pro Ser Gly 
            660                 665                 670         


Ser Lys Met Gln Leu Leu Glu Thr Glu Phe Ser His Thr Val Gly Glu 
        675                 680                 685             


Leu Ile Glu Val His Leu Arg Arg Gln Asp Ser Ile Pro Ala Phe Leu 
    690                 695                 700                 


Ser Ser Leu Thr Leu Glu Leu Phe Ser Arg Gln Thr Val Ala 
705                 710                 715             


<210>  8256
<211>  144
<212>  PRT
<213>  Homo Sapiens

<400>  8256

Met Glu Asp Leu Gly Glu Asn Thr Met Val Leu Ser Thr Leu Arg Ser 
1               5                   10                  15      


Leu Asn Asn Phe Ile Ser Gln Arg Val Glu Gly Gly Ser Gly Leu Asp 
            20                  25                  30          


Ile Ser Thr Ser Ala Pro Gly Ser Leu Gln Met Gln Tyr Gln Gln Ser 
        35                  40                  45              


Met Gln Arg Glu Val Asp Arg Asn Gln Glu Leu Leu Thr Arg Ile Arg 
    50                  55                  60                  


Gln Leu Gln Glu Arg Glu Ala Gly Ala Glu Glu Lys Met Gln Glu Gln 
65                  70                  75                  80  


Leu Glu Arg Asn Arg Gln Cys Gln Gln Asn Leu Asp Ala Ala Ser Lys 
                85                  90                  95      


Arg Leu Arg Glu Lys Glu Asp Ser Leu Ala Gln Ala Gly Glu Thr Ile 
            100                 105                 110         


Asn Ala Leu Lys Gly Arg Ile Ser Glu Leu Gln Trp Ser Val Met Asp 
        115                 120                 125             


Gln Glu Met Arg Val Lys Arg Leu Glu Ser Glu Lys Gln Glu Leu Gln 
    130                 135                 140                 


<210>  8257
<211>  626
<212>  PRT
<213>  Homo Sapiens

<400>  8257

Met Leu Pro Ala Arg Gly Cys Val Arg Lys Arg Thr Val Trp Pro Arg 
1               5                   10                  15      


Leu Ala Arg Val Leu Ile Val Thr Leu Leu Thr Leu Glu Leu Ser Tyr 
            20                  25                  30          


Ala Pro Leu Pro Cys Gln Leu Ser Gly Val Pro Tyr Asn Thr Gly Asp 
        35                  40                  45              


Pro Val Gly Arg Trp Ala Arg Pro Cys Ile Trp Pro Cys Pro Trp His 
    50                  55                  60                  


Thr Thr Ile Asn Ala Leu Lys Gly Arg Ile Ser Glu Leu Gln Trp Ser 
65                  70                  75                  80  


Val Met Asp Gln Glu Met Arg Val Lys Arg Leu Glu Ser Glu Lys Gln 
                85                  90                  95      


Glu Leu Gln Glu Gln Leu Asp Leu Gln His Lys Lys Cys Gln Glu Ala 
            100                 105                 110         


Asn Gln Lys Ile Gln Glu Leu Gln Ala Ser Gln Glu Ala Arg Ala Asp 
        115                 120                 125             


His Glu Gln Gln Ile Lys Asp Leu Glu Gln Lys Leu Ser Leu Gln Glu 
    130                 135                 140                 


Gln Asp Ala Ala Ile Val Lys Asn Met Lys Ser Glu Leu Val Arg Leu 
145                 150                 155                 160 


Pro Arg Leu Glu Arg Glu Leu Lys Gln Leu Arg Glu Glu Ser Ala His 
                165                 170                 175     


Leu Arg Glu Met Arg Glu Thr Asn Gly Leu Leu Gln Glu Glu Leu Glu 
            180                 185                 190         


Gly Leu Gln Arg Lys Leu Gly Arg Gln Glu Lys Met Gln Glu Thr Leu 
        195                 200                 205             


Val Gly Leu Glu Leu Glu Asn Glu Arg Leu Leu Ala Lys Leu Gln Ser 
    210                 215                 220                 


Trp Glu Arg Leu Asp Gln Thr Met Gly Leu Ser Ile Arg Thr Pro Glu 
225                 230                 235                 240 


Asp Leu Ser Arg Phe Val Val Glu Leu Gln Gln Arg Glu Leu Ala Leu 
                245                 250                 255     


Lys Asp Lys Asn Ser Ala Val Thr Ser Ser Ala Arg Gly Leu Glu Lys 
            260                 265                 270         


Ala Arg Gln Gln Leu Gln Glu Glu Leu Arg Gln Val Ser Gly Gln Leu 
        275                 280                 285             


Leu Glu Glu Arg Lys Lys Arg Glu Thr His Glu Ala Leu Ala Arg Arg 
    290                 295                 300                 


Leu Gln Lys Arg Val Leu Leu Leu Thr Lys Glu Arg Asp Gly Met Arg 
305                 310                 315                 320 


Ala Ile Leu Gly Ser Tyr Asp Ser Glu Leu Thr Pro Ala Glu Tyr Ser 
                325                 330                 335     


Pro Gln Leu Thr Arg Arg Met Arg Glu Ala Glu Asp Met Val Gln Lys 
            340                 345                 350         


Val His Ser His Ser Ala Glu Met Glu Ala Gln Leu Ser Gln Ala Leu 
        355                 360                 365             


Glu Glu Leu Gly Gly Gln Lys Gln Arg Ala Asp Met Leu Glu Met Glu 
    370                 375                 380                 


Leu Lys Met Leu Lys Ser Gln Ser Ser Ser Ala Glu Gln Ser Phe Leu 
385                 390                 395                 400 


Phe Ser Arg Glu Glu Ala Asp Thr Leu Arg Leu Lys Val Glu Glu Leu 
                405                 410                 415     


Glu Gly Glu Arg Ser Arg Leu Glu Glu Glu Lys Arg Met Leu Glu Ala 
            420                 425                 430         


Gln Leu Glu Arg Arg Ala Leu Gln Gly Asp Tyr Asp Gln Ser Arg Thr 
        435                 440                 445             


Lys Val Leu His Met Ser Leu Asn Pro Thr Ser Val Ala Arg Gln Arg 
    450                 455                 460                 


Leu Arg Glu Asp His Ser Gln Leu Gln Ala Glu Cys Glu Arg Leu Arg 
465                 470                 475                 480 


Gly Leu Leu Arg Ala Met Glu Arg Gly Gly Thr Val Pro Ala Asp Leu 
                485                 490                 495     


Glu Ala Ala Ala Ala Ser Leu Pro Ser Ser Lys Glu Val Ala Glu Leu 
            500                 505                 510         


Lys Lys Gln Val Glu Ser Ala Glu Leu Lys Asn Gln Arg Leu Lys Glu 
        515                 520                 525             


Val Phe Gln Thr Lys Ile Gln Glu Phe Arg Lys Ala Cys Tyr Thr Leu 
    530                 535                 540                 


Thr Gly Tyr Gln Ile Asp Ile Thr Thr Glu Asn Gln Tyr Arg Leu Thr 
545                 550                 555                 560 


Ser Leu Tyr Ala Glu His Pro Gly Asp Cys Leu Ile Phe Lys Ala Thr 
                565                 570                 575     


Ser Pro Ser Gly Ser Lys Met Gln Leu Leu Glu Thr Glu Phe Ser His 
            580                 585                 590         


Thr Val Gly Glu Leu Ile Glu Val His Leu Arg Arg Gln Asp Ser Ile 
        595                 600                 605             


Pro Ala Phe Leu Ser Ser Leu Thr Leu Glu Leu Phe Ser Arg Gln Thr 
    610                 615                 620                 


Val Ala 
625     


<210>  8258
<211>  205
<212>  PRT
<213>  Homo Sapiens

<400>  8258

Met Gln Glu Gln Leu Glu Arg Asn Arg Gln Cys Gln Gln Asn Leu Asp 
1               5                   10                  15      


Ala Ala Ser Lys Arg Leu Arg Glu Lys Glu Asp Ser Leu Ala Gln Ala 
            20                  25                  30          


Gly Glu Thr Ile Asn Ala Leu Lys Gly Arg Ile Ser Glu Leu Gln Trp 
        35                  40                  45              


Ser Val Met Asp Gln Glu Met Arg Val Lys Arg Leu Glu Ser Glu Lys 
    50                  55                  60                  


Gln Glu Leu Gln Glu Gln Leu Asp Leu Gln His Lys Lys Cys Gln Glu 
65                  70                  75                  80  


Ala Asn Gln Lys Ile Gln Glu Leu Gln Ala Ser Gln Glu Ala Arg Ala 
                85                  90                  95      


Asp His Glu Gln Gln Ile Lys Asp Leu Glu Gln Lys Leu Ser Leu Gln 
            100                 105                 110         


Glu Gln Asp Ala Ala Ile Val Lys Asn Met Lys Ser Glu Leu Val Arg 
        115                 120                 125             


Leu Pro Arg Leu Glu Arg Glu Leu Lys Gln Leu Arg Glu Glu Ser Ala 
    130                 135                 140                 


His Leu Arg Glu Met Arg Glu Thr Asn Gly Leu Leu Gln Glu Glu Leu 
145                 150                 155                 160 


Glu Gly Leu Gln Arg Lys Leu Gly Arg Gln Glu Lys Met Gln Glu Thr 
                165                 170                 175     


Leu Val Gly Leu Glu Leu Glu Asn Glu Arg Leu Leu Ala Lys Leu Gln 
            180                 185                 190         


Ser Trp Glu Arg Leu Asp Gln Thr Met Gly Leu Ser Ile 
        195                 200                 205 


<210>  8259
<211>  213
<212>  PRT
<213>  Homo Sapiens

<400>  8259

Met Gln Met Glu Leu Ser His Lys Arg Ala Arg Val Glu Leu Glu Arg 
1               5                   10                  15      


Ala Ala Ser Thr Ser Ala Arg Asn Tyr Glu Arg Glu Val Asp Arg Asn 
            20                  25                  30          


Gln Glu Leu Leu Thr Arg Ile Arg Gln Leu Gln Glu Arg Glu Ala Gly 
        35                  40                  45              


Ala Glu Glu Lys Met Gln Glu Gln Leu Glu Arg Asn Arg Gln Cys Gln 
    50                  55                  60                  


Gln Asn Leu Asp Ala Ala Ser Lys Arg Leu Arg Glu Lys Glu Asp Ser 
65                  70                  75                  80  


Leu Ala Gln Ala Gly Glu Thr Ile Asn Ala Leu Lys Gly Arg Ile Ser 
                85                  90                  95      


Glu Leu Gln Trp Ser Val Met Asp Gln Glu Met Arg Val Lys Arg Leu 
            100                 105                 110         


Glu Ser Glu Lys Gln Glu Leu Gln Glu Gln Leu Asp Leu Gln His Lys 
        115                 120                 125             


Lys Cys Gln Glu Ala Asn Gln Lys Ile Gln Glu Leu Gln Ala Ser Gln 
    130                 135                 140                 


Glu Ala Arg Ala Asp His Glu Gln Gln Ile Lys Asp Leu Glu Gln Lys 
145                 150                 155                 160 


Leu Ser Leu Gln Glu Gln Asp Ala Ala Ile Val Lys Asn Met Lys Ser 
                165                 170                 175     


Glu Leu Val Arg Leu Pro Arg Leu Glu Arg Glu Leu Lys Gln Leu Arg 
            180                 185                 190         


Glu Glu Ser Ala His Leu Arg Glu Met Arg Glu Thr Asn Gly Leu Leu 
        195                 200                 205             


Gln Glu Glu Leu Glu 
    210             


<210>  8260
<211>  41
<212>  PRT
<213>  Homo Sapiens

<400>  8260

Met Arg Ala Ile Leu Gly Ser Tyr Asp Ser Glu Leu Thr Pro Ala Glu 
1               5                   10                  15      


Tyr Ser Pro Gln Leu Thr Arg Arg Met Arg Glu Ala Glu Asp Met Val 
            20                  25                  30          


Gln Lys Val His Ser His Ser Ala Glu 
        35                  40      


<210>  8261
<211>  80
<212>  PRT
<213>  Homo Sapiens

<400>  8261

Met Arg Ala Ile Leu Gly Ser Tyr Asp Ser Glu Leu Thr Pro Ala Glu 
1               5                   10                  15      


Tyr Ser Pro Gln Leu Thr Arg Arg Met Arg Glu Ala Glu Asp Met Val 
            20                  25                  30          


Gln Lys Val His Ser His Ser Ala Glu Met Glu Ala Gln Leu Ser Gln 
        35                  40                  45              


Ala Leu Glu Glu Leu Gly Gly Gln Lys Gln Arg Ala Asp Met Leu Glu 
    50                  55                  60                  


Met Glu Leu Lys Met Leu Lys Ser Gln Ser Ser Ser Ala Glu Gln Ser 
65                  70                  75                  80  


<210>  8262
<211>  266
<212>  PRT
<213>  Homo Sapiens

<400>  8262

Met Arg Glu Leu Glu Phe Ala Lys Leu Glu Cys Cys Leu Ala Trp Gln 
1               5                   10                  15      


Leu Gln Ala Ser Arg Arg Glu Leu Glu Met Glu Leu Lys Met Leu Lys 
            20                  25                  30          


Ser Gln Ser Ser Ser Ala Glu Gln Ser Phe Leu Phe Ser Arg Glu Glu 
        35                  40                  45              


Ala Asp Thr Leu Arg Leu Lys Val Glu Glu Leu Glu Gly Glu Arg Ser 
    50                  55                  60                  


Arg Leu Glu Glu Glu Lys Arg Met Leu Glu Ala Gln Leu Glu Arg Arg 
65                  70                  75                  80  


Ala Leu Gln Gly Asp Tyr Asp Gln Ser Arg Thr Lys Val Leu His Met 
                85                  90                  95      


Ser Leu Asn Pro Thr Ser Val Ala Arg Gln Arg Leu Arg Glu Asp His 
            100                 105                 110         


Ser Gln Leu Gln Ala Glu Cys Glu Arg Leu Arg Gly Leu Leu Arg Ala 
        115                 120                 125             


Met Glu Arg Gly Gly Thr Val Pro Ala Asp Leu Glu Ala Ala Ala Ala 
    130                 135                 140                 


Ser Leu Pro Ser Ser Lys Glu Val Ala Glu Leu Lys Lys Gln Val Glu 
145                 150                 155                 160 


Ser Ala Glu Leu Lys Asn Gln Arg Leu Lys Glu Val Phe Gln Thr Lys 
                165                 170                 175     


Ile Gln Glu Phe Arg Lys Ala Cys Tyr Thr Leu Thr Gly Tyr Gln Ile 
            180                 185                 190         


Asp Ile Thr Thr Glu Asn Gln Tyr Arg Leu Thr Ser Leu Tyr Ala Glu 
        195                 200                 205             


His Pro Gly Asp Cys Leu Ile Phe Lys Ala Thr Ser Pro Ser Gly Ser 
    210                 215                 220                 


Lys Met Gln Leu Leu Glu Thr Glu Phe Ser His Thr Val Gly Glu Leu 
225                 230                 235                 240 


Ile Glu Val His Leu Arg Arg Gln Asp Ser Ile Pro Ala Phe Leu Ser 
                245                 250                 255     


Ser Leu Thr Leu Glu Leu Phe Ser Arg Gln 
            260                 265     


<210>  8263
<211>  122
<212>  PRT
<213>  Homo Sapiens

<400>  8263

Met Ser Leu Asn Pro Thr Ser Val Ala Arg Gln Arg Leu Arg Glu Asp 
1               5                   10                  15      


His Ser Gln Leu Gln Ala Glu Cys Glu Arg Leu Arg Gly Leu Leu Arg 
            20                  25                  30          


Ala Met Glu Arg Gly Gly Thr Val Pro Ala Asp Leu Glu Ala Ala Ala 
        35                  40                  45              


Ala Ser Leu Pro Ser Ser Lys Glu Val Ala Glu Leu Lys Lys Gln Val 
    50                  55                  60                  


Glu Ser Ala Glu Leu Lys Asn Gln Arg Leu Lys Glu Val Phe Gln Thr 
65                  70                  75                  80  


Lys Ile Gln Glu Phe Arg Lys Ala Cys Tyr Thr Leu Thr Gly Tyr Gln 
                85                  90                  95      


Ile Asp Ile Thr Thr Glu Asn Gln Tyr Arg Leu Thr Ser Leu Tyr Ala 
            100                 105                 110         


Glu His Pro Gly Asp Cys Leu Ile Phe Lys 
        115                 120         


<210>  8264
<211>  199
<212>  PRT
<213>  Homo Sapiens

<400>  8264

Met Val Ser Leu Arg Pro Cys Leu Pro Gly Leu Pro Thr Gln His Leu 
1               5                   10                  15      


Glu Glu Pro Cys Pro Gly Asp Tyr Ser Ala Arg Gly Leu Glu Lys Ala 
            20                  25                  30          


Arg Gln Gln Leu Gln Glu Glu Leu Arg Gln Val Ser Gly Gln Leu Leu 
        35                  40                  45              


Glu Glu Arg Lys Lys Arg Glu Thr His Glu Ala Leu Ala Arg Arg Leu 
    50                  55                  60                  


Gln Lys Arg Val Leu Leu Leu Thr Lys Glu Arg Asp Gly Met Arg Ala 
65                  70                  75                  80  


Ile Leu Gly Ser Tyr Asp Ser Glu Leu Thr Pro Ala Glu Tyr Ser Pro 
                85                  90                  95      


Gln Leu Thr Arg Arg Met Arg Glu Ala Glu Asp Met Val Gln Lys Val 
            100                 105                 110         


His Ser His Ser Ala Glu Met Glu Ala Gln Leu Ser Gln Ala Leu Glu 
        115                 120                 125             


Glu Leu Gly Gly Gln Lys Gln Arg Ala Asp Met Leu Glu Met Glu Leu 
    130                 135                 140                 


Lys Met Leu Lys Ser Gln Ser Ser Ser Ala Glu Gln Ser Phe Leu Phe 
145                 150                 155                 160 


Ser Arg Glu Glu Ala Asp Thr Leu Arg Leu Lys Val Glu Glu Leu Glu 
                165                 170                 175     


Gly Glu Arg Ser Arg Leu Glu Glu Glu Lys Arg Met Leu Glu Ala Gln 
            180                 185                 190         


Leu Glu Arg Arg Ala Leu Gln 
        195                 


<210>  8265
<211>  58
<212>  PRT
<213>  Homo Sapiens

<400>  8265

Met Ile Phe Leu Thr Ala Leu Pro Leu Phe Trp Ile Met Ile Ser Ala 
1               5                   10                  15      


Ser Arg Gly Gly His Trp Gly Ala Trp Met Pro Ser Ser Ile Ser Ala 
            20                  25                  30          


Phe Glu Gly Thr Cys Val Ser Ile Pro Cys Arg Phe Asp Phe Pro Asp 
        35                  40                  45              


Glu Leu Arg Pro Ala Val Val His Gly Val 
    50                  55              


<210>  8266
<211>  158
<212>  PRT
<213>  Homo Sapiens

<400>  8266

Met Ile Phe Leu Thr Ala Leu Pro Leu Phe Trp Ile Met Ile Ser Ala 
1               5                   10                  15      


Ser Arg Gly Gly His Trp Gly Ala Trp Met Pro Ser Ser Ile Ser Ala 
            20                  25                  30          


Phe Glu Gly Thr Cys Val Ser Ile Pro Cys Arg Phe Asp Phe Pro Asp 
        35                  40                  45              


Glu Leu Arg Pro Ala Val Val His Gly Val Trp Tyr Phe Asn Ser Pro 
    50                  55                  60                  


Tyr Pro Lys Asn Tyr Pro Pro Val Val Phe Lys Ser Arg Thr Gln Val 
65                  70                  75                  80  


Val His Glu Ser Phe Gln Gly Arg Ser Arg Leu Leu Gly Asp Leu Gly 
                85                  90                  95      


Leu Arg Asn Cys Thr Leu Leu Leu Ser Asn Val Ser Pro Glu Leu Gly 
            100                 105                 110         


Gly Lys Tyr Tyr Phe Arg Gly Asp Leu Gly Gly Tyr Asn Gln Tyr Thr 
        115                 120                 125             


Phe Ser Glu His Ser Val Leu Asp Ile Val Asn Thr Pro Asn Ile Val 
    130                 135                 140                 


Val Pro Pro Glu Val Val Ala Gly Thr Glu Val Glu Val Ser 
145                 150                 155             


<210>  8267
<211>  582
<212>  PRT
<213>  Homo Sapiens

<400>  8267

Met Ile Phe Leu Thr Ala Leu Pro Leu Phe Trp Ile Met Ile Ser Ala 
1               5                   10                  15      


Ser Arg Gly Gly His Trp Gly Ala Trp Met Pro Ser Ser Ile Ser Ala 
            20                  25                  30          


Phe Glu Gly Thr Cys Val Ser Ile Pro Cys Arg Phe Asp Phe Pro Asp 
        35                  40                  45              


Glu Leu Arg Pro Ala Val Val His Gly Val Trp Tyr Phe Asn Ser Pro 
    50                  55                  60                  


Tyr Pro Lys Asn Tyr Pro Pro Val Val Phe Lys Ser Arg Thr Gln Val 
65                  70                  75                  80  


Val His Glu Ser Phe Gln Gly Arg Ser Arg Leu Leu Gly Asp Leu Gly 
                85                  90                  95      


Leu Arg Asn Cys Thr Leu Leu Leu Ser Asn Val Ser Pro Glu Leu Gly 
            100                 105                 110         


Gly Lys Tyr Tyr Phe Arg Gly Asp Leu Gly Gly Tyr Asn Gln Tyr Thr 
        115                 120                 125             


Phe Ser Glu His Ser Val Leu Asp Ile Val Asn Thr Pro Asn Ile Val 
    130                 135                 140                 


Val Pro Pro Glu Val Val Ala Gly Thr Glu Val Glu Val Ser Cys Met 
145                 150                 155                 160 


Val Pro Asp Asn Cys Pro Glu Leu Arg Pro Glu Leu Ser Trp Leu Gly 
                165                 170                 175     


His Glu Gly Leu Gly Glu Pro Ala Val Leu Gly Arg Leu Arg Glu Asp 
            180                 185                 190         


Glu Gly Thr Trp Val Gln Val Ser Leu Leu His Phe Val Pro Thr Arg 
        195                 200                 205             


Glu Ala Asn Gly His Arg Leu Gly Cys Gln Ala Ser Phe Pro Asn Thr 
    210                 215                 220                 


Thr Leu Gln Phe Glu Gly Tyr Ala Ser Met Asp Val Lys Tyr Pro Pro 
225                 230                 235                 240 


Val Ile Val Glu Met Asn Ser Ser Val Glu Ala Ile Glu Gly Ser His 
                245                 250                 255     


Val Ser Leu Leu Cys Gly Ala Asp Ser Asn Pro Pro Pro Leu Leu Thr 
            260                 265                 270         


Trp Met Arg Asp Gly Thr Val Leu Arg Glu Ala Val Ala Glu Ser Leu 
        275                 280                 285             


Leu Leu Glu Leu Glu Glu Val Thr Pro Ala Glu Asp Gly Val Tyr Ala 
    290                 295                 300                 


Cys Leu Ala Glu Asn Ala Tyr Gly Gln Asp Asn Arg Thr Val Gly Leu 
305                 310                 315                 320 


Ser Val Met Tyr Ala Pro Trp Lys Pro Thr Val Asn Gly Thr Met Val 
                325                 330                 335     


Ala Val Glu Gly Glu Thr Val Ser Ile Leu Cys Ser Thr Gln Ser Asn 
            340                 345                 350         


Pro Asp Pro Ile Leu Thr Ile Phe Lys Glu Lys Gln Ile Leu Ser Thr 
        355                 360                 365             


Val Ile Tyr Glu Ser Glu Leu Gln Leu Glu Leu Pro Ala Val Ser Pro 
    370                 375                 380                 


Glu Asp Asp Gly Glu Tyr Trp Cys Val Ala Glu Asn Gln Tyr Gly Gln 
385                 390                 395                 400 


Arg Ala Thr Ala Phe Asn Leu Ser Val Glu Phe Ala Pro Val Leu Leu 
                405                 410                 415     


Leu Glu Ser His Cys Ala Ala Ala Arg Asp Thr Val Gln Cys Leu Cys 
            420                 425                 430         


Val Val Lys Ser Asn Pro Glu Pro Ser Val Ala Phe Glu Leu Pro Ser 
        435                 440                 445             


Arg Asn Val Thr Val Asn Glu Ser Glu Arg Glu Phe Val Tyr Ser Glu 
    450                 455                 460                 


Arg Ser Gly Leu Val Leu Thr Ser Ile Leu Thr Leu Arg Gly Gln Ala 
465                 470                 475                 480 


Gln Ala Pro Pro Arg Val Ile Cys Thr Ala Arg Asn Leu Tyr Gly Ala 
                485                 490                 495     


Lys Ser Leu Glu Leu Pro Phe Gln Gly Ala His Arg Leu Met Trp Ala 
            500                 505                 510         


Lys Ile Gly Pro Val Gly Ala Val Val Ala Phe Ala Ile Leu Ile Ala 
        515                 520                 525             


Ile Val Cys Tyr Ile Thr Gln Thr Arg Arg Lys Lys Asn Val Thr Glu 
    530                 535                 540                 


Ser Pro Ser Phe Ser Ala Gly Asp Asn Pro Pro Val Leu Phe Ser Ser 
545                 550                 555                 560 


Asp Phe Arg Ile Ser Gly Ala Pro Glu Lys Tyr Glu Ser Lys Glu Val 
                565                 570                 575     


Ser Thr Leu Glu Ser His 
            580         


<210>  8268
<211>  626
<212>  PRT
<213>  Homo Sapiens

<400>  8268

Met Ile Phe Leu Thr Ala Leu Pro Leu Phe Trp Ile Met Ile Ser Ala 
1               5                   10                  15      


Ser Arg Gly Gly His Trp Gly Ala Trp Met Pro Ser Ser Ile Ser Ala 
            20                  25                  30          


Phe Glu Gly Thr Cys Val Ser Ile Pro Cys Arg Phe Asp Phe Pro Asp 
        35                  40                  45              


Glu Leu Arg Pro Ala Val Val His Gly Val Trp Tyr Phe Asn Ser Pro 
    50                  55                  60                  


Tyr Pro Lys Asn Tyr Pro Pro Val Val Phe Lys Ser Arg Thr Gln Val 
65                  70                  75                  80  


Val His Glu Ser Phe Gln Gly Arg Ser Arg Leu Leu Gly Asp Leu Gly 
                85                  90                  95      


Leu Arg Asn Cys Thr Leu Leu Leu Ser Asn Val Ser Pro Glu Leu Gly 
            100                 105                 110         


Gly Lys Tyr Tyr Phe Arg Gly Asp Leu Gly Gly Tyr Asn Gln Tyr Thr 
        115                 120                 125             


Phe Ser Glu His Ser Val Leu Asp Ile Val Asn Thr Pro Asn Ile Val 
    130                 135                 140                 


Val Pro Pro Glu Val Val Ala Gly Thr Glu Val Glu Val Ser Cys Met 
145                 150                 155                 160 


Val Pro Asp Asn Cys Pro Glu Leu Arg Pro Glu Leu Ser Trp Leu Gly 
                165                 170                 175     


His Glu Gly Leu Gly Glu Pro Ala Val Leu Gly Arg Leu Arg Glu Asp 
            180                 185                 190         


Glu Gly Thr Trp Val Gln Val Ser Leu Leu His Phe Val Pro Thr Arg 
        195                 200                 205             


Glu Ala Asn Gly His Arg Leu Gly Cys Gln Ala Ser Phe Pro Asn Thr 
    210                 215                 220                 


Thr Leu Gln Phe Glu Gly Tyr Ala Ser Met Asp Val Lys Tyr Pro Pro 
225                 230                 235                 240 


Val Ile Val Glu Met Asn Ser Ser Val Glu Ala Ile Glu Gly Ser His 
                245                 250                 255     


Val Ser Leu Leu Cys Gly Ala Asp Ser Asn Pro Pro Pro Leu Leu Thr 
            260                 265                 270         


Trp Met Arg Asp Gly Thr Val Leu Arg Glu Ala Val Ala Glu Ser Leu 
        275                 280                 285             


Leu Leu Glu Leu Glu Glu Val Thr Pro Ala Glu Asp Gly Val Tyr Ala 
    290                 295                 300                 


Cys Leu Ala Glu Asn Ala Tyr Gly Gln Asp Asn Arg Thr Val Gly Leu 
305                 310                 315                 320 


Ser Val Met Tyr Ala Pro Trp Lys Pro Thr Val Asn Gly Thr Met Val 
                325                 330                 335     


Ala Val Glu Gly Glu Thr Val Ser Ile Leu Cys Ser Thr Gln Ser Asn 
            340                 345                 350         


Pro Asp Pro Ile Leu Thr Ile Phe Lys Glu Lys Gln Ile Leu Ser Thr 
        355                 360                 365             


Val Ile Tyr Glu Ser Glu Leu Gln Leu Glu Leu Pro Ala Val Ser Pro 
    370                 375                 380                 


Glu Asp Asp Gly Glu Tyr Trp Cys Val Ala Glu Asn Gln Tyr Gly Gln 
385                 390                 395                 400 


Arg Ala Thr Ala Phe Asn Leu Ser Val Glu Phe Ala Pro Val Leu Leu 
                405                 410                 415     


Leu Glu Ser His Cys Ala Ala Ala Arg Asp Thr Val Gln Cys Leu Cys 
            420                 425                 430         


Val Val Lys Ser Asn Pro Glu Pro Ser Val Ala Phe Glu Leu Pro Ser 
        435                 440                 445             


Arg Asn Val Thr Val Asn Glu Ser Glu Arg Glu Phe Val Tyr Ser Glu 
    450                 455                 460                 


Arg Ser Gly Leu Val Leu Thr Ser Ile Leu Thr Leu Arg Gly Gln Ala 
465                 470                 475                 480 


Gln Ala Pro Pro Arg Val Ile Cys Thr Ala Arg Asn Leu Tyr Gly Ala 
                485                 490                 495     


Lys Ser Leu Glu Leu Pro Phe Gln Gly Ala His Arg Leu Met Trp Ala 
            500                 505                 510         


Lys Ile Gly Pro Val Gly Ala Val Val Ala Phe Ala Ile Leu Ile Ala 
        515                 520                 525             


Ile Val Cys Tyr Ile Thr Gln Thr Arg Arg Lys Lys Asn Val Thr Glu 
    530                 535                 540                 


Ser Pro Ser Phe Ser Ala Gly Asp Asn Pro Pro Val Leu Phe Ser Ser 
545                 550                 555                 560 


Asp Phe Arg Ile Ser Gly Ala Pro Glu Lys Tyr Glu Ser Glu Arg Arg 
                565                 570                 575     


Leu Gly Ser Glu Arg Arg Leu Leu Gly Leu Arg Gly Glu Pro Pro Glu 
            580                 585                 590         


Leu Asp Leu Ser Tyr Ser His Ser Asp Leu Gly Lys Arg Pro Thr Lys 
        595                 600                 605             


Asp Ser Tyr Thr Leu Thr Glu Glu Leu Ala Glu Tyr Ala Glu Ile Arg 
    610                 615                 620                 


Val Lys 
625     


<210>  8269
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  8269

Met Pro Ser Ser Ile Ser Ala Phe Glu Gly Thr Cys Val Ser Ile Pro 
1               5                   10                  15      


Cys Arg Phe Asp Phe Pro Asp Glu Leu Arg Pro Ala Val Val His Gly 
            20                  25                  30          


Val Trp Tyr Phe Asn Ser Pro Tyr Pro Lys Asn Tyr Pro Pro Val Val 
        35                  40                  45              


Phe Lys Ser Arg Thr Gln Val Val His Glu Ser Phe Gln Gly Arg Ser 
    50                  55                  60                  


Arg Leu Leu Gly Asp Leu Gly Leu Arg Asn Cys Thr Leu Leu Leu Ser 
65                  70                  75                  80  


Asn Val Ser Pro Glu Leu Gly Gly Lys Tyr Tyr Phe Arg Gly Asp Leu 
                85                  90                  95      


Gly Gly Tyr Asn Gln Tyr Thr Phe Ser Glu His Ser Val Leu Asp Ile 
            100                 105                 110         


Val Asn Thr Pro Asn Ile Val Val Pro Pro Glu Val Val Ala Gly Thr 
        115                 120                 125             


Glu Val Glu 
    130     


<210>  8270
<211>  601
<212>  PRT
<213>  Homo Sapiens

<400>  8270

Met Pro Ser Ser Ile Ser Ala Phe Glu Gly Thr Cys Val Ser Ile Pro 
1               5                   10                  15      


Cys Arg Phe Asp Phe Pro Asp Glu Leu Arg Pro Ala Val Val His Gly 
            20                  25                  30          


Val Trp Tyr Phe Asn Ser Pro Tyr Pro Lys Asn Tyr Pro Pro Val Val 
        35                  40                  45              


Phe Lys Ser Arg Thr Gln Val Val His Glu Ser Phe Gln Gly Arg Ser 
    50                  55                  60                  


Arg Leu Leu Gly Asp Leu Gly Leu Arg Asn Cys Thr Leu Leu Leu Ser 
65                  70                  75                  80  


Asn Val Ser Pro Glu Leu Gly Gly Lys Tyr Tyr Phe Arg Gly Asp Leu 
                85                  90                  95      


Gly Gly Tyr Asn Gln Tyr Thr Phe Ser Glu His Ser Val Leu Asp Ile 
            100                 105                 110         


Val Asn Thr Pro Asn Ile Val Val Pro Pro Glu Val Val Ala Gly Thr 
        115                 120                 125             


Glu Val Glu Val Ser Cys Met Val Pro Asp Asn Cys Pro Glu Leu Arg 
    130                 135                 140                 


Pro Glu Leu Ser Trp Leu Gly His Glu Gly Leu Gly Glu Pro Ala Val 
145                 150                 155                 160 


Leu Gly Arg Leu Arg Glu Asp Glu Gly Thr Trp Val Gln Val Ser Leu 
                165                 170                 175     


Leu His Phe Val Pro Thr Arg Glu Ala Asn Gly His Arg Leu Gly Cys 
            180                 185                 190         


Gln Ala Ser Phe Pro Asn Thr Thr Leu Gln Phe Glu Gly Tyr Ala Ser 
        195                 200                 205             


Met Asp Val Lys Tyr Pro Pro Val Ile Val Glu Met Asn Ser Ser Val 
    210                 215                 220                 


Glu Ala Ile Glu Gly Ser His Val Ser Leu Leu Cys Gly Ala Asp Ser 
225                 230                 235                 240 


Asn Pro Pro Pro Leu Leu Thr Trp Met Arg Asp Gly Thr Val Leu Arg 
                245                 250                 255     


Glu Ala Val Ala Glu Ser Leu Leu Leu Glu Leu Glu Glu Val Thr Pro 
            260                 265                 270         


Ala Glu Asp Gly Val Tyr Ala Cys Leu Ala Glu Asn Ala Tyr Gly Gln 
        275                 280                 285             


Asp Asn Arg Thr Val Gly Leu Ser Val Met Tyr Ala Pro Trp Lys Pro 
    290                 295                 300                 


Thr Val Asn Gly Thr Met Val Ala Val Glu Gly Glu Thr Val Ser Ile 
305                 310                 315                 320 


Leu Cys Ser Thr Gln Ser Asn Pro Asp Pro Ile Leu Thr Ile Phe Lys 
                325                 330                 335     


Glu Lys Gln Ile Leu Ser Thr Val Ile Tyr Glu Ser Glu Leu Gln Leu 
            340                 345                 350         


Glu Leu Pro Ala Val Ser Pro Glu Asp Asp Gly Glu Tyr Trp Cys Val 
        355                 360                 365             


Ala Glu Asn Gln Tyr Gly Gln Arg Ala Thr Ala Phe Asn Leu Ser Val 
    370                 375                 380                 


Glu Phe Ala Pro Val Leu Leu Leu Glu Ser His Cys Ala Ala Ala Arg 
385                 390                 395                 400 


Asp Thr Val Gln Cys Leu Cys Val Val Lys Ser Asn Pro Glu Pro Ser 
                405                 410                 415     


Val Ala Phe Glu Leu Pro Ser Arg Asn Val Thr Val Asn Glu Ser Glu 
            420                 425                 430         


Arg Glu Phe Val Tyr Ser Glu Arg Ser Gly Leu Val Leu Thr Ser Ile 
        435                 440                 445             


Leu Thr Leu Arg Gly Gln Ala Gln Ala Pro Pro Arg Val Ile Cys Thr 
    450                 455                 460                 


Ala Arg Asn Leu Tyr Gly Ala Lys Ser Leu Glu Leu Pro Phe Gln Gly 
465                 470                 475                 480 


Ala His Arg Leu Met Trp Ala Lys Ile Gly Pro Val Gly Ala Val Val 
                485                 490                 495     


Ala Phe Ala Ile Leu Ile Ala Ile Val Cys Tyr Ile Thr Gln Thr Arg 
            500                 505                 510         


Arg Lys Lys Asn Val Thr Glu Ser Pro Ser Phe Ser Ala Gly Asp Asn 
        515                 520                 525             


Pro Pro Val Leu Phe Ser Ser Asp Phe Arg Ile Ser Gly Ala Pro Glu 
    530                 535                 540                 


Lys Tyr Glu Ser Glu Arg Arg Leu Gly Ser Glu Arg Arg Leu Leu Gly 
545                 550                 555                 560 


Leu Arg Gly Glu Pro Pro Glu Leu Asp Leu Ser Tyr Ser His Ser Asp 
                565                 570                 575     


Leu Gly Lys Arg Pro Thr Lys Asp Ser Tyr Thr Leu Thr Glu Glu Leu 
            580                 585                 590         


Ala Glu Tyr Ala Glu Ile Arg Val Lys 
        595                 600     


<210>  8271
<211>  134
<212>  PRT
<213>  Homo Sapiens

<400>  8271

Met Ala Ala Arg Trp Arg Phe Trp Cys Val Ser Val Thr Met Val Val 
1               5                   10                  15      


Ala Leu Leu Ile Val Cys Asp Val Pro Ser Ala Ser Ala Gln Arg Lys 
            20                  25                  30          


Lys Glu Met Val Leu Ser Glu Lys Val Ser Gln Leu Met Glu Trp Thr 
        35                  40                  45              


Asn Lys Arg Pro Val Ile Arg Met Asn Gly Asp Lys Phe Arg Arg Leu 
    50                  55                  60                  


Val Lys Ala Pro Pro Arg Asn Tyr Ser Val Ile Val Met Phe Thr Ala 
65                  70                  75                  80  


Leu Gln Leu His Arg Gln Cys Val Val Cys Lys Gln Ala Asp Glu Glu 
                85                  90                  95      


Phe Gln Ile Leu Ala Asn Ser Trp Arg Tyr Ser Ser Ala Phe Thr Asn 
            100                 105                 110         


Arg Ile Phe Phe Ala Met Val Asp Phe Asp Glu Gly Ser Asp Val Phe 
        115                 120                 125             


Gln Met Phe Gln Val Phe 
    130                 


<210>  8272
<211>  335
<212>  PRT
<213>  Homo Sapiens

<400>  8272

Met Ala Ala Arg Trp Arg Phe Trp Cys Val Ser Val Thr Met Val Val 
1               5                   10                  15      


Ala Leu Leu Ile Val Cys Asp Val Pro Ser Ala Ser Ala Gln Arg Lys 
            20                  25                  30          


Lys Glu Met Val Leu Ser Glu Lys Val Ser Gln Leu Met Glu Trp Thr 
        35                  40                  45              


Asn Lys Arg Pro Val Ile Arg Met Asn Gly Asp Lys Phe Arg Arg Leu 
    50                  55                  60                  


Val Lys Ala Pro Pro Arg Asn Tyr Ser Val Ile Val Met Phe Thr Ala 
65                  70                  75                  80  


Leu Gln Leu His Arg Gln Cys Val Val Cys Lys Gln Ala Asp Glu Glu 
                85                  90                  95      


Phe Gln Ile Leu Ala Asn Ser Trp Arg Tyr Ser Ser Ala Phe Thr Asn 
            100                 105                 110         


Arg Ile Phe Phe Ala Met Val Asp Phe Asp Glu Gly Ser Asp Val Phe 
        115                 120                 125             


Gln Met Leu Asn Met Asn Ser Ala Pro Thr Phe Ile Asn Phe Pro Ala 
    130                 135                 140                 


Lys Gly Lys Pro Lys Arg Gly Asp Thr Tyr Glu Leu Gln Val Arg Gly 
145                 150                 155                 160 


Phe Ser Ala Glu Gln Ile Ala Arg Trp Ile Ala Asp Arg Thr Asp Val 
                165                 170                 175     


Asn Ile Arg Val Ile Arg Pro Pro Asn Tyr Ala Gly Pro Leu Met Leu 
            180                 185                 190         


Gly Leu Leu Leu Ala Val Ile Gly Gly Leu Val Tyr Leu Arg Arg Ser 
        195                 200                 205             


Asn Met Glu Phe Leu Phe Asn Lys Thr Gly Trp Ala Phe Ala Ala Leu 
    210                 215                 220                 


Cys Phe Val Leu Ala Met Thr Ser Gly Gln Met Trp Asn His Ile Arg 
225                 230                 235                 240 


Gly Pro Pro Tyr Ala His Lys Asn Pro His Thr Gly His Val Asn Tyr 
                245                 250                 255     


Ile His Gly Ser Ser Gln Ala Gln Phe Val Ala Glu Thr His Ile Val 
            260                 265                 270         


Leu Leu Phe Asn Gly Gly Val Thr Leu Gly Met Val Leu Leu Cys Glu 
        275                 280                 285             


Ala Ala Thr Ser Asp Met Asp Ile Gly Lys Arg Lys Ile Met Cys Val 
    290                 295                 300                 


Ala Gly Ile Gly Leu Val Val Leu Phe Phe Ser Trp Met Leu Ser Ile 
305                 310                 315                 320 


Phe Arg Ser Lys Tyr His Gly Tyr Pro Tyr Ser Phe Leu Met Ser 
                325                 330                 335 


<210>  8273
<211>  367
<212>  PRT
<213>  Homo Sapiens

<400>  8273

Met Arg Lys Gly Lys Gly Pro Ile Cys Leu Phe Ser Arg Pro Thr Leu 
1               5                   10                  15      


Arg Pro Ser Arg Ser Lys Val Ser Leu Ile Glu Gly Arg Gly Ala Asn 
            20                  25                  30          


Met Ala Ala Arg Trp Arg Phe Trp Cys Val Ser Val Thr Met Val Val 
        35                  40                  45              


Ala Leu Leu Ile Val Cys Asp Val Pro Ser Ala Ser Ala Gln Arg Lys 
    50                  55                  60                  


Lys Glu Met Val Leu Ser Glu Lys Val Ser Gln Leu Met Glu Trp Thr 
65                  70                  75                  80  


Asn Lys Arg Pro Val Ile Arg Met Asn Gly Asp Lys Phe Arg Arg Leu 
                85                  90                  95      


Val Lys Ala Pro Pro Arg Asn Tyr Ser Val Ile Val Met Phe Thr Ala 
            100                 105                 110         


Leu Gln Leu His Arg Gln Cys Val Val Cys Lys Gln Ala Asp Glu Glu 
        115                 120                 125             


Phe Gln Ile Leu Ala Asn Ser Trp Arg Tyr Ser Ser Ala Phe Thr Asn 
    130                 135                 140                 


Arg Ile Phe Phe Ala Met Val Asp Phe Asp Glu Gly Ser Asp Val Phe 
145                 150                 155                 160 


Gln Met Leu Asn Met Asn Ser Ala Pro Thr Phe Ile Asn Phe Pro Ala 
                165                 170                 175     


Lys Gly Lys Pro Lys Arg Gly Asp Thr Tyr Glu Leu Gln Val Arg Gly 
            180                 185                 190         


Phe Ser Ala Glu Gln Ile Ala Arg Trp Ile Ala Asp Arg Thr Asp Val 
        195                 200                 205             


Asn Ile Arg Val Ile Arg Pro Pro Asn Tyr Ala Gly Pro Leu Met Leu 
    210                 215                 220                 


Gly Leu Leu Leu Ala Val Ile Gly Gly Leu Val Tyr Leu Arg Arg Ser 
225                 230                 235                 240 


Asn Met Glu Phe Leu Phe Asn Lys Thr Gly Trp Ala Phe Ala Ala Leu 
                245                 250                 255     


Cys Phe Val Leu Ala Met Thr Ser Gly Gln Met Trp Asn His Ile Arg 
            260                 265                 270         


Gly Pro Pro Tyr Ala His Lys Asn Pro His Thr Gly His Val Asn Tyr 
        275                 280                 285             


Ile His Gly Ser Ser Gln Ala Gln Phe Val Ala Glu Thr His Ile Val 
    290                 295                 300                 


Leu Leu Phe Asn Gly Gly Val Thr Leu Gly Met Val Leu Leu Cys Glu 
305                 310                 315                 320 


Ala Ala Thr Ser Asp Met Asp Ile Gly Lys Arg Lys Ile Met Cys Val 
                325                 330                 335     


Ala Gly Ile Gly Leu Val Val Leu Phe Phe Ser Trp Met Leu Ser Ile 
            340                 345                 350         


Phe Arg Ser Lys Tyr His Gly Tyr Pro Tyr Ser Phe Leu Met Ser 
        355                 360                 365         


<210>  8274
<211>  367
<212>  PRT
<213>  Homo Sapiens

<400>  8274

Met Arg Lys Gly Lys Gly Pro Ile Cys Leu Phe Ser Arg Pro Thr Leu 
1               5                   10                  15      


Arg Pro Ser Arg Ser Lys Val Ser Leu Ile Glu Gly Arg Gly Ala Asn 
            20                  25                  30          


Met Ala Ala Arg Trp Arg Phe Trp Cys Val Ser Val Thr Met Val Val 
        35                  40                  45              


Ala Leu Leu Ile Val Cys Asp Val Pro Ser Ala Ser Ala Gln Arg Lys 
    50                  55                  60                  


Lys Glu Met Val Leu Ser Glu Lys Val Ser Gln Leu Met Glu Trp Thr 
65                  70                  75                  80  


Asn Lys Arg Pro Val Ile Arg Met Asn Gly Asp Lys Phe Arg Arg Leu 
                85                  90                  95      


Val Lys Ala Pro Pro Arg Asn Tyr Ser Val Ile Val Met Phe Thr Ala 
            100                 105                 110         


Leu Gln Leu His Arg Gln Cys Val Val Cys Lys Gln Ala Asp Glu Glu 
        115                 120                 125             


Phe Gln Ile Leu Ala Asn Ser Trp Arg Tyr Ser Ser Ala Phe Thr Asn 
    130                 135                 140                 


Arg Ile Phe Phe Ala Met Val Asp Phe Asp Glu Gly Ser Asp Val Phe 
145                 150                 155                 160 


Gln Met Leu Asn Met Asn Ser Ala Pro Thr Phe Ile Asn Phe Pro Ala 
                165                 170                 175     


Lys Gly Lys Pro Lys Arg Gly Asp Thr Tyr Glu Leu Gln Val Arg Gly 
            180                 185                 190         


Phe Ser Ala Glu Gln Ile Ala Arg Trp Ile Ala Asp Arg Thr Asp Val 
        195                 200                 205             


Asn Ile Arg Val Ile Arg Pro Pro Asn Tyr Ala Gly Pro Leu Met Leu 
    210                 215                 220                 


Gly Leu Leu Leu Ala Val Ile Gly Gly Leu Val Tyr Leu Arg Arg Ser 
225                 230                 235                 240 


Asn Met Glu Phe Leu Phe Asn Lys Thr Gly Trp Ala Phe Ala Ala Leu 
                245                 250                 255     


Cys Phe Val Leu Ala Met Thr Ser Gly Gln Met Trp Asn His Ile Arg 
            260                 265                 270         


Gly Pro Pro Tyr Ala His Lys Asn Pro His Thr Gly His Val Asn Tyr 
        275                 280                 285             


Ile His Gly Ser Ser Gln Ala Gln Phe Val Ala Glu Thr His Ile Val 
    290                 295                 300                 


Leu Leu Phe Asn Gly Gly Val Thr Leu Gly Met Val Leu Leu Cys Glu 
305                 310                 315                 320 


Ala Ala Thr Ser Asp Met Asp Ile Gly Lys Arg Lys Ile Met Cys Val 
                325                 330                 335     


Ala Gly Ile Gly Leu Val Val Leu Phe Phe Ser Trp Met Leu Ser Ile 
            340                 345                 350         


Phe Arg Ser Lys Tyr His Gly Tyr Pro Tyr Ser Phe Leu Met Ser 
        355                 360                 365         


<210>  8275
<211>  234
<212>  PRT
<213>  Homo Sapiens

<400>  8275

Met Gly Pro Gly Gly Arg Val Ala Arg Leu Leu Ala Pro Leu Met Trp 
1               5                   10                  15      


Arg Arg Ala Val Ser Ser Val Ala Gly Ser Ala Val Gly Ala Glu Pro 
            20                  25                  30          


Gly Leu Arg Leu Leu Ala Val Gln Arg Leu Pro Val Gly Ala Ala Phe 
        35                  40                  45              


Cys Arg Ala Cys Gln Thr Pro Asn Phe Val Arg Gly Leu His Ser Glu 
    50                  55                  60                  


Pro Gly Leu Glu Glu Arg Ala Glu Gly Thr Val Asn Glu Gly Arg Pro 
65                  70                  75                  80  


Glu Ser Asp Ala Ala Asp His Thr Gly Pro Lys Phe Asp Ile Asp Met 
                85                  90                  95      


Met Val Ser Leu Leu Arg Gln Glu Asn Ala Arg Asp Ile Cys Val Ile 
            100                 105                 110         


Gln Val Pro Pro Glu Met Arg Tyr Thr Asp Tyr Phe Val Ile Val Ser 
        115                 120                 125             


Gly Thr Ser Thr Arg His Leu His Ala Met Ala Phe Tyr Val Val Lys 
    130                 135                 140                 


Met Tyr Lys His Leu Lys Cys Lys Arg Asp Pro His Val Lys Ile Glu 
145                 150                 155                 160 


Gly Lys Asp Thr Asp Asp Trp Leu Cys Val Asp Phe Gly Ser Met Val 
                165                 170                 175     


Ile His Leu Met Leu Pro Glu Thr Arg Glu Ile Tyr Glu Leu Glu Lys 
            180                 185                 190         


Leu Trp Thr Leu Arg Ser Tyr Asp Asp Gln Leu Ala Gln Ile Ala Pro 
        195                 200                 205             


Glu Thr Val Pro Glu Asp Phe Ile Leu Gly Ile Glu Asp Asp Thr Ser 
    210                 215                 220                 


Ser Val Thr Pro Val Glu Leu Lys Cys Glu 
225                 230                 


<210>  8276
<211>  686
<212>  PRT
<213>  Homo Sapiens

<400>  8276

Met Leu Leu Arg Gly Val Leu Leu Ala Leu Gln Ala Leu Gln Leu Ala 
1               5                   10                  15      


Gly Ala Leu Asp Leu Pro Ala Gly Ser Cys Ala Phe Glu Glu Ser Thr 
            20                  25                  30          


Cys Gly Phe Asp Ser Val Leu Ala Ser Leu Pro Trp Ile Leu Asn Glu 
        35                  40                  45              


Glu Gly His Tyr Ile Tyr Val Asp Thr Ser Phe Gly Lys Gln Gly Glu 
    50                  55                  60                  


Lys Ala Val Leu Leu Ser Pro Asp Leu Gln Ala Glu Glu Trp Ser Cys 
65                  70                  75                  80  


Leu Arg Leu Val Tyr Gln Ile Thr Thr Ser Ser Glu Ser Leu Ser Asp 
                85                  90                  95      


Pro Ser Gln Leu Asn Leu Tyr Met Arg Phe Glu Asp Glu Ser Phe Asp 
            100                 105                 110         


Arg Leu Leu Trp Ser Ala Lys Glu Pro Ser Asp Ser Trp Leu Ile Ala 
        115                 120                 125             


Ser Leu Asp Leu Gln Asn Ser Ser Lys Lys Phe Lys Ile Leu Ile Glu 
    130                 135                 140                 


Gly Val Leu Gly Gln Gly Asn Thr Ala Ser Ile Ala Leu Phe Glu Ile 
145                 150                 155                 160 


Lys Met Thr Thr Gly Tyr Cys Ile Glu Cys Asp Phe Glu Glu Asn His 
                165                 170                 175     


Leu Cys Gly Phe Val Asn Arg Trp Asn Pro Asn Val Asn Trp Phe Val 
            180                 185                 190         


Gly Gly Gly Ser Ile Arg Asn Val His Ser Ile Leu Pro Gln Asp His 
        195                 200                 205             


Thr Phe Lys Ser Glu Leu Gly His Tyr Met Tyr Val Asp Ser Val Tyr 
    210                 215                 220                 


Val Lys His Phe Gln Glu Val Ala Gln Leu Ile Ser Pro Leu Thr Thr 
225                 230                 235                 240 


Ala Pro Met Ala Gly Cys Leu Ser Phe Tyr Tyr Gln Ile Gln Gln Gly 
                245                 250                 255     


Asn Asp Asn Val Phe Ser Leu Tyr Thr Arg Asp Val Ala Gly Leu Tyr 
            260                 265                 270         


Glu Glu Ile Trp Lys Ala Asp Arg Pro Gly Asn Ala Ala Trp Asn Leu 
        275                 280                 285             


Ala Glu Val Glu Phe Ser Ala Pro Tyr Pro Met Glu Val Ile Phe Glu 
    290                 295                 300                 


Val Ala Phe Asn Gly Pro Lys Gly Gly Tyr Val Ala Leu Asp Asp Ile 
305                 310                 315                 320 


Ser Phe Ser Pro Val His Cys Gln Asn Gln Thr Glu Leu Leu Phe Ser 
                325                 330                 335     


Ala Val Glu Ala Ser Cys Asn Phe Glu Gln Asp Leu Cys Asn Phe Tyr 
            340                 345                 350         


Gln Asp Lys Glu Gly Pro Gly Trp Thr Arg Val Lys Val Lys Pro Asn 
        355                 360                 365             


Met Tyr Arg Ala Gly Asp His Thr Thr Gly Leu Gly Tyr Tyr Leu Leu 
    370                 375                 380                 


Ala Asn Thr Lys Phe Thr Ser Gln Pro Gly Tyr Ile Gly Arg Leu Tyr 
385                 390                 395                 400 


Gly Pro Ser Leu Pro Gly Asn Leu Gln Tyr Cys Leu Arg Phe His Tyr 
                405                 410                 415     


Ala Ile Tyr Gly Phe Leu Lys Met Ser Asp Thr Leu Ala Val Tyr Ile 
            420                 425                 430         


Phe Glu Glu Asn His Val Val Gln Glu Lys Ile Trp Ser Val Leu Glu 
        435                 440                 445             


Ser Pro Arg Gly Val Trp Met Gln Ala Glu Ile Thr Phe Lys Lys Pro 
    450                 455                 460                 


Met Pro Thr Lys Val Val Phe Met Ser Leu Cys Lys Ser Phe Trp Asp 
465                 470                 475                 480 


Cys Gly Leu Val Ala Leu Asp Asp Ile Thr Ile Gln Leu Gly Ser Cys 
                485                 490                 495     


Ser Ser Ser Glu Lys Leu Pro Pro Pro Pro Gly Glu Cys Thr Phe Glu 
            500                 505                 510         


Gln Asp Glu Cys Thr Phe Thr Gln Glu Lys Arg Asn Arg Ser Ser Trp 
        515                 520                 525             


His Arg Arg Arg Gly Glu Thr Pro Thr Ser Tyr Thr Gly Pro Lys Gly 
    530                 535                 540                 


Asp His Thr Thr Gly Val Gly Tyr Tyr Met Tyr Ile Glu Ala Ser His 
545                 550                 555                 560 


Met Val Tyr Gly Gln Lys Ala Arg Leu Leu Ser Arg Pro Leu Arg Gly 
                565                 570                 575     


Val Ser Gly Lys His Cys Leu Thr Phe Phe Tyr His Met Tyr Gly Gly 
            580                 585                 590         


Gly Thr Gly Leu Leu Ser Val Tyr Leu Lys Lys Glu Glu Asp Ser Glu 
        595                 600                 605             


Glu Ser Leu Leu Trp Arg Arg Arg Gly Glu Gln Ser Ile Ser Trp Leu 
    610                 615                 620                 


Arg Ala Leu Ile Glu Tyr Ser Cys Glu Arg Gln His Gln Ile Ile Phe 
625                 630                 635                 640 


Glu Ala Ile Arg Gly Val Ser Ile Arg Ser Asp Ile Ala Ile Asp Asp 
                645                 650                 655     


Val Lys Phe Gln Ala Gly Pro Cys Gly Glu Met Glu Asp Thr Thr Gln 
            660                 665                 670         


Gln Ser Ser Gly Tyr Ser Glu Asp Leu Asn Glu Ile Glu Tyr 
        675                 680                 685     


<210>  8277
<211>  165
<212>  PRT
<213>  Homo Sapiens

<400>  8277

Met Gly Ala Tyr Ala Arg Ala Ser Gly Val Cys Ala Arg Gly Cys Leu 
1               5                   10                  15      


Asp Ser Ala Gly Pro Trp Thr Met Ser Arg Ala Leu Arg Pro Pro Leu 
            20                  25                  30          


Pro Pro Leu Cys Phe Phe Leu Leu Leu Leu Ala Ala Ala Gly Ala Arg 
        35                  40                  45              


Ala Gly Gly Tyr Glu Ser Arg Met Thr Ser Ser Thr Pro Val Cys Ser 
    50                  55                  60                  


Thr Ser Trp Thr Arg Ser Ser Leu Pro Cys Trp Gln Ile Pro Pro Val 
65                  70                  75                  80  


Ala Ser Phe Thr Trp Arg Leu Pro Ser Ser Pro Val Gly Gly Thr Ser 
                85                  90                  95      


Arg Gln Met Pro His Arg Lys Ser Cys Glu Thr Leu Cys Ala Arg Met 
            100                 105                 110         


Gly Phe Asp Gly Phe Phe Phe Gly Arg Leu Asp Tyr Gln Asp Lys Trp 
        115                 120                 125             


Val Arg Met Gln Lys Leu Glu Met Glu Gln Val Trp Arg Ala Ser Thr 
    130                 135                 140                 


Ser Leu Lys Pro Pro Thr Ala Asp Leu Phe Thr Gly Val Leu Pro Asn 
145                 150                 155                 160 


Gly Tyr Asn Pro Pro 
                165 


<210>  8278
<211>  1010
<212>  PRT
<213>  Homo Sapiens

<400>  8278

Met Gly Ala Tyr Ala Arg Ala Ser Gly Val Cys Ala Arg Gly Cys Leu 
1               5                   10                  15      


Asp Ser Ala Gly Pro Trp Thr Met Ser Arg Ala Leu Arg Pro Pro Leu 
            20                  25                  30          


Pro Pro Leu Cys Phe Phe Leu Leu Leu Leu Ala Ala Ala Gly Ala Arg 
        35                  40                  45              


Ala Gly Gly Tyr Glu Thr Cys Pro Thr Val Gln Pro Asn Met Leu Asn 
    50                  55                  60                  


Val His Leu Leu Pro His Thr His Asp Asp Val Gly Trp Leu Lys Thr 
65                  70                  75                  80  


Val Asp Gln Tyr Phe Tyr Gly Ile Lys Asn Asp Ile Gln His Ala Gly 
                85                  90                  95      


Val Gln Tyr Ile Leu Asp Ser Val Ile Ser Ala Leu Leu Ala Asp Pro 
            100                 105                 110         


Thr Arg Arg Phe Ile Tyr Val Glu Ile Ala Phe Phe Ser Arg Trp Trp 
        115                 120                 125             


His Gln Gln Thr Asn Ala Thr Gln Glu Val Val Arg Asp Leu Val Arg 
    130                 135                 140                 


Gln Gly Arg Leu Glu Phe Ala Asn Gly Gly Trp Val Met Asn Asp Glu 
145                 150                 155                 160 


Ala Ala Thr His Tyr Gly Ala Ile Val Asp Gln Met Thr Leu Gly Leu 
                165                 170                 175     


Arg Phe Leu Glu Asp Thr Phe Gly Asn Asp Gly Arg Pro Arg Val Ala 
            180                 185                 190         


Trp His Ile Asp Pro Phe Gly His Ser Arg Glu Gln Ala Ser Leu Phe 
        195                 200                 205             


Ala Gln Met Gly Phe Asp Gly Phe Phe Phe Gly Arg Leu Asp Tyr Gln 
    210                 215                 220                 


Asp Lys Trp Val Arg Met Gln Lys Leu Glu Met Glu Gln Val Trp Arg 
225                 230                 235                 240 


Ala Ser Thr Ser Leu Lys Pro Pro Thr Ala Asp Leu Phe Thr Gly Val 
                245                 250                 255     


Leu Pro Asn Gly Tyr Asn Pro Pro Arg Asn Leu Cys Trp Asp Val Leu 
            260                 265                 270         


Cys Val Asp Gln Pro Leu Val Glu Asp Pro Arg Ser Pro Glu Tyr Asn 
        275                 280                 285             


Ala Lys Glu Leu Val Asp Tyr Phe Leu Asn Val Ala Thr Ala Gln Gly 
    290                 295                 300                 


Arg Tyr Tyr Arg Thr Asn His Thr Val Met Thr Met Gly Ser Asp Phe 
305                 310                 315                 320 


Gln Tyr Glu Asn Ala Asn Met Trp Phe Lys Asn Leu Asp Lys Leu Ile 
                325                 330                 335     


Arg Leu Val Asn Ala Gln Ala Lys Gly Ser Ser Val His Val Leu Tyr 
            340                 345                 350         


Ser Thr Pro Ala Cys Tyr Leu Trp Glu Leu Asn Lys Ala Asn Leu Thr 
        355                 360                 365             


Trp Ser Val Lys His Asp Asp Phe Phe Pro Tyr Ala Asp Gly Pro His 
    370                 375                 380                 


Gln Phe Trp Thr Gly Tyr Phe Ser Ser Arg Pro Ala Leu Lys Arg Tyr 
385                 390                 395                 400 


Glu Arg Leu Ser Tyr Asn Phe Leu Gln Val Cys Asn Gln Leu Glu Ala 
                405                 410                 415     


Leu Val Gly Leu Ala Ala Asn Val Gly Pro Tyr Gly Ser Gly Asp Ser 
            420                 425                 430         


Ala Pro Leu Asn Glu Ala Met Ala Val Leu Gln His His Asp Ala Val 
        435                 440                 445             


Ser Gly Thr Ser Arg Gln His Val Ala Asn Asp Tyr Ala Arg Gln Leu 
    450                 455                 460                 


Ala Ala Gly Trp Gly Pro Cys Glu Val Leu Leu Ser Asn Ala Leu Ala 
465                 470                 475                 480 


Arg Leu Arg Gly Phe Lys Asp His Phe Thr Phe Cys Gln Gln Leu Asn 
                485                 490                 495     


Ile Ser Ile Cys Pro Leu Ser Gln Thr Ala Ala Arg Phe Gln Val Ile 
            500                 505                 510         


Val Tyr Asn Pro Leu Gly Arg Lys Val Asn Trp Met Val Arg Leu Pro 
        515                 520                 525             


Val Ser Glu Gly Val Phe Val Val Lys Asp Pro Asn Gly Arg Thr Val 
    530                 535                 540                 


Pro Ser Asp Val Val Ile Phe Pro Ser Ser Asp Ser Gln Ala His Pro 
545                 550                 555                 560 


Pro Glu Leu Leu Phe Ser Ala Ser Leu Pro Ala Leu Gly Phe Ser Thr 
                565                 570                 575     


Tyr Ser Val Ala Gln Val Pro Arg Trp Lys Pro Gln Ala Arg Ala Pro 
            580                 585                 590         


Gln Pro Ile Pro Arg Arg Ser Trp Ser Pro Ala Leu Thr Ile Glu Asn 
        595                 600                 605             


Glu His Ile Arg Ala Thr Phe Asp Pro Asp Thr Gly Leu Leu Met Glu 
    610                 615                 620                 


Ile Met Asn Met Asn Gln Gln Leu Leu Leu Pro Val Arg Gln Thr Phe 
625                 630                 635                 640 


Phe Trp Tyr Asn Ala Ser Ile Gly Asp Asn Glu Ser Asp Gln Ala Ser 
                645                 650                 655     


Gly Ala Tyr Ile Phe Arg Pro Asn Gln Gln Lys Pro Leu Pro Val Ser 
            660                 665                 670         


Arg Trp Ala Gln Ile His Leu Val Lys Thr Pro Leu Val Gln Glu Val 
        675                 680                 685             


His Gln Asn Phe Ser Ala Trp Cys Ser Gln Val Val Arg Leu Tyr Pro 
    690                 695                 700                 


Gly Gln Arg His Leu Glu Leu Glu Trp Ser Val Gly Pro Ile Pro Val 
705                 710                 715                 720 


Gly Asp Thr Trp Gly Lys Glu Val Ile Ser Arg Phe Asp Thr Pro Leu 
                725                 730                 735     


Glu Thr Lys Gly Arg Phe Tyr Thr Asp Ser Asn Gly Arg Glu Ile Leu 
            740                 745                 750         


Glu Arg Arg Arg Asp Tyr Arg Pro Thr Trp Lys Leu Asn Gln Thr Glu 
        755                 760                 765             


Pro Val Ala Gly Asn Tyr Tyr Pro Val Asn Thr Arg Ile Tyr Ile Thr 
    770                 775                 780                 


Asp Gly Asn Met Gln Leu Thr Val Leu Thr Asp Arg Ser Gln Gly Gly 
785                 790                 795                 800 


Ser Ser Leu Arg Asp Gly Ser Leu Glu Leu Met Val His Arg Arg Leu 
                805                 810                 815     


Leu Lys Asp Asp Gly Arg Gly Val Ser Glu Pro Leu Met Glu Asn Gly 
            820                 825                 830         


Ser Gly Ala Trp Val Arg Gly Arg His Leu Val Leu Leu Asp Thr Ala 
        835                 840                 845             


Gln Ala Ala Ala Ala Gly His Arg Leu Leu Ala Glu Gln Glu Val Leu 
    850                 855                 860                 


Ala Pro Gln Val Val Leu Ala Pro Gly Gly Gly Ala Ala Tyr Asn Leu 
865                 870                 875                 880 


Gly Ala Pro Pro Arg Thr Gln Phe Ser Gly Leu Arg Arg Asp Leu Pro 
                885                 890                 895     


Pro Ser Val His Leu Leu Thr Leu Ala Ser Trp Gly Pro Glu Met Val 
            900                 905                 910         


Leu Leu Arg Leu Glu His Gln Phe Ala Val Gly Glu Asp Ser Gly Arg 
        915                 920                 925             


Asn Leu Ser Ala Pro Val Thr Leu Asn Leu Arg Asp Leu Phe Ser Thr 
    930                 935                 940                 


Phe Thr Ile Thr Arg Leu Gln Glu Thr Thr Leu Val Ala Asn Gln Leu 
945                 950                 955                 960 


Arg Glu Ala Ala Ser Arg Leu Lys Trp Thr Thr Asn Thr Gly Pro Thr 
                965                 970                 975     


Pro His Gln Thr Pro Tyr Gln Leu Asp Pro Ala Asn Ile Thr Leu Glu 
            980                 985                 990         


Pro Met Glu Ile Arg Thr Phe Leu  Ala Ser Val Gln Trp  Lys Glu Val 
        995                 1000                 1005             


Asp Gly  
    1010 


<210>  8279
<211>  1011
<212>  PRT
<213>  Homo Sapiens

<400>  8279

Met Gly Ala Tyr Ala Arg Ala Ser Gly Val Cys Ala Arg Gly Cys Leu 
1               5                   10                  15      


Asp Ser Ala Gly Pro Trp Thr Met Ser Arg Ala Leu Arg Pro Pro Leu 
            20                  25                  30          


Pro Pro Leu Cys Phe Phe Leu Leu Leu Leu Ala Ala Ala Gly Ala Arg 
        35                  40                  45              


Ala Gly Gly Tyr Glu Thr Cys Pro Thr Val Gln Pro Asn Met Leu Asn 
    50                  55                  60                  


Val His Leu Leu Pro His Thr His Asp Asp Val Gly Trp Leu Lys Thr 
65                  70                  75                  80  


Val Asp Gln Tyr Phe Tyr Gly Ile Lys Asn Asp Ile Gln His Ala Gly 
                85                  90                  95      


Val Gln Tyr Ile Leu Asp Ser Val Ile Ser Ala Leu Leu Ala Asp Pro 
            100                 105                 110         


Thr Arg Arg Phe Ile Tyr Val Glu Ile Ala Phe Phe Ser Arg Trp Trp 
        115                 120                 125             


His Gln Gln Thr Asn Ala Thr Gln Glu Val Val Arg Asp Leu Val Arg 
    130                 135                 140                 


Gln Gly Arg Leu Glu Phe Ala Asn Gly Gly Trp Val Met Asn Asp Glu 
145                 150                 155                 160 


Ala Ala Thr His Tyr Gly Ala Ile Val Asp Gln Met Thr Leu Gly Leu 
                165                 170                 175     


Arg Phe Leu Glu Asp Thr Phe Gly Asn Asp Gly Arg Pro Arg Val Ala 
            180                 185                 190         


Trp His Ile Asp Pro Phe Gly His Ser Arg Glu Gln Ala Ser Leu Phe 
        195                 200                 205             


Ala Gln Met Gly Phe Asp Gly Phe Phe Phe Gly Arg Leu Asp Tyr Gln 
    210                 215                 220                 


Asp Lys Trp Val Arg Met Gln Lys Leu Glu Met Glu Gln Val Trp Arg 
225                 230                 235                 240 


Ala Ser Thr Ser Leu Lys Pro Pro Thr Ala Asp Leu Phe Thr Gly Val 
                245                 250                 255     


Leu Pro Asn Gly Tyr Asn Pro Pro Arg Asn Leu Cys Trp Asp Val Leu 
            260                 265                 270         


Cys Val Asp Gln Pro Leu Val Glu Asp Pro Arg Ser Pro Glu Tyr Asn 
        275                 280                 285             


Ala Lys Glu Leu Val Asp Tyr Phe Leu Asn Val Ala Thr Ala Gln Gly 
    290                 295                 300                 


Arg Tyr Tyr Arg Thr Asn His Thr Val Met Thr Met Gly Ser Asp Phe 
305                 310                 315                 320 


Gln Tyr Glu Asn Ala Asn Met Trp Phe Lys Asn Leu Asp Lys Leu Ile 
                325                 330                 335     


Arg Leu Val Asn Ala Gln Gln Ala Lys Gly Ser Ser Val His Val Leu 
            340                 345                 350         


Tyr Ser Thr Pro Ala Cys Tyr Leu Trp Glu Leu Asn Lys Ala Asn Leu 
        355                 360                 365             


Thr Trp Ser Val Lys His Asp Asp Phe Phe Pro Tyr Ala Asp Gly Pro 
    370                 375                 380                 


His Gln Phe Trp Thr Gly Tyr Phe Ser Ser Arg Pro Ala Leu Lys Arg 
385                 390                 395                 400 


Tyr Glu Arg Leu Ser Tyr Asn Phe Leu Gln Val Cys Asn Gln Leu Glu 
                405                 410                 415     


Ala Leu Val Gly Leu Ala Ala Asn Val Gly Pro Tyr Gly Ser Gly Asp 
            420                 425                 430         


Ser Ala Pro Leu Asn Glu Ala Met Ala Val Leu Gln His His Asp Ala 
        435                 440                 445             


Val Ser Gly Thr Ser Arg Gln His Val Ala Asn Asp Tyr Ala Arg Gln 
    450                 455                 460                 


Leu Ala Ala Gly Trp Gly Pro Cys Glu Val Leu Leu Ser Asn Ala Leu 
465                 470                 475                 480 


Ala Arg Leu Arg Gly Phe Lys Asp His Phe Thr Phe Cys Gln Gln Leu 
                485                 490                 495     


Asn Ile Ser Ile Cys Pro Leu Ser Gln Thr Ala Ala Arg Phe Gln Val 
            500                 505                 510         


Ile Val Tyr Asn Pro Leu Gly Arg Lys Val Asn Trp Met Val Arg Leu 
        515                 520                 525             


Pro Val Ser Glu Gly Val Phe Val Val Lys Asp Pro Asn Gly Arg Thr 
    530                 535                 540                 


Val Pro Ser Asp Val Val Ile Phe Pro Ser Ser Asp Ser Gln Ala His 
545                 550                 555                 560 


Pro Pro Glu Leu Leu Phe Ser Ala Ser Leu Pro Ala Leu Gly Phe Ser 
                565                 570                 575     


Thr Tyr Ser Val Ala Gln Val Pro Arg Trp Lys Pro Gln Ala Arg Ala 
            580                 585                 590         


Pro Gln Pro Ile Pro Arg Arg Ser Trp Ser Pro Ala Leu Thr Ile Glu 
        595                 600                 605             


Asn Glu His Ile Arg Ala Thr Phe Asp Pro Asp Thr Gly Leu Leu Met 
    610                 615                 620                 


Glu Ile Met Asn Met Asn Gln Gln Leu Leu Leu Pro Val Arg Gln Thr 
625                 630                 635                 640 


Phe Phe Trp Tyr Asn Ala Ser Ile Gly Asp Asn Glu Ser Asp Gln Ala 
                645                 650                 655     


Ser Gly Ala Tyr Ile Phe Arg Pro Asn Gln Gln Lys Pro Leu Pro Val 
            660                 665                 670         


Ser Arg Trp Ala Gln Ile His Leu Val Lys Thr Pro Leu Val Gln Glu 
        675                 680                 685             


Val His Gln Asn Phe Ser Ala Trp Cys Ser Gln Val Val Arg Leu Tyr 
    690                 695                 700                 


Pro Gly Gln Arg His Leu Glu Leu Glu Trp Ser Val Gly Pro Ile Pro 
705                 710                 715                 720 


Val Gly Asp Thr Trp Gly Lys Glu Val Ile Ser Arg Phe Asp Thr Pro 
                725                 730                 735     


Leu Glu Thr Lys Gly Arg Phe Tyr Thr Asp Ser Asn Gly Arg Glu Ile 
            740                 745                 750         


Leu Glu Arg Arg Arg Asp Tyr Arg Pro Thr Trp Lys Leu Asn Gln Thr 
        755                 760                 765             


Glu Pro Val Ala Gly Asn Tyr Tyr Pro Val Asn Thr Arg Ile Tyr Ile 
    770                 775                 780                 


Thr Asp Gly Asn Met Gln Leu Thr Val Leu Thr Asp Arg Ser Gln Gly 
785                 790                 795                 800 


Gly Ser Ser Leu Arg Asp Gly Ser Leu Glu Leu Met Val His Arg Arg 
                805                 810                 815     


Leu Leu Lys Asp Asp Gly Arg Gly Val Ser Glu Pro Leu Met Glu Asn 
            820                 825                 830         


Gly Ser Gly Ala Trp Val Arg Gly Arg His Leu Val Leu Leu Asp Thr 
        835                 840                 845             


Ala Gln Ala Ala Ala Ala Gly His Arg Leu Leu Ala Glu Gln Glu Val 
    850                 855                 860                 


Leu Ala Pro Gln Val Val Leu Ala Pro Gly Gly Gly Ala Ala Tyr Asn 
865                 870                 875                 880 


Leu Gly Ala Pro Pro Arg Thr Gln Phe Ser Gly Leu Arg Arg Asp Leu 
                885                 890                 895     


Pro Pro Ser Val His Leu Leu Thr Leu Ala Ser Trp Gly Pro Glu Met 
            900                 905                 910         


Val Leu Leu Arg Leu Glu His Gln Phe Ala Val Gly Glu Asp Ser Gly 
        915                 920                 925             


Arg Asn Leu Ser Ala Pro Val Thr Leu Asn Leu Arg Asp Leu Phe Ser 
    930                 935                 940                 


Thr Phe Thr Ile Thr Arg Leu Gln Glu Thr Thr Leu Val Ala Asn Gln 
945                 950                 955                 960 


Leu Arg Glu Ala Ala Ser Arg Leu Lys Trp Thr Thr Asn Thr Gly Pro 
                965                 970                 975     


Thr Pro His Gln Thr Pro Tyr Gln Leu Asp Pro Ala Asn Ile Thr Leu 
            980                 985                 990         


Glu Pro Met Glu Ile Arg Thr Phe  Leu Ala Ser Val Gln  Trp Lys Glu 
        995                 1000                 1005             


Val Asp  Gly 
    1010     


<210>  8280
<211>  172
<212>  PRT
<213>  Homo Sapiens

<400>  8280

Met Gly Ala Tyr Ala Arg Ala Ser Gly Val Cys Ala Arg Gly Cys Leu 
1               5                   10                  15      


Asp Ser Ala Gly Pro Trp Thr Met Ser Arg Ala Leu Arg Pro Pro Leu 
            20                  25                  30          


Pro Pro Leu Cys Phe Phe Leu Leu Leu Leu Ala Ala Ala Gly Ala Arg 
        35                  40                  45              


Ala Gly Gly Tyr Glu Val Cys Val Phe Gly Val Pro Val Gln Thr Cys 
    50                  55                  60                  


Pro Thr Val Gln Pro Asn Met Leu Asn Val His Leu Leu Pro His Thr 
65                  70                  75                  80  


His Asp Asp Val Gly Trp Leu Lys Thr Val Asp Gln Tyr Phe Tyr Gly 
                85                  90                  95      


Ile Lys Asn Asp Ile Gln His Ala Gly Val Gln Tyr Ile Leu Asp Ser 
            100                 105                 110         


Val Ile Ser Ala Leu Leu Ala Asp Pro Thr Arg Arg Phe Ile Tyr Val 
        115                 120                 125             


Glu Ile Ala Phe Phe Ser Arg Trp Trp His Gln Gln Thr Asn Ala Thr 
    130                 135                 140                 


Gln Glu Val Val Arg Asp Leu Val Arg Gln Gly Arg Leu Glu Phe Ala 
145                 150                 155                 160 


Asn Gly Gly Trp Val Met Asn Asp Glu Ala Ala Thr 
                165                 170         


<210>  8281
<211>  140
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8281

Xaa Leu Ala Ala Gly Trp Gly Pro Cys Glu Val Leu Leu Ser Asn Ala 
1               5                   10                  15      


Leu Ala Arg Leu Arg Gly Phe Lys Asp His Phe Thr Phe Cys Gln Gln 
            20                  25                  30          


Leu Asn Ile Ser Ile Cys Pro Leu Ser Gln Thr Ala Ala Arg Phe Gln 
        35                  40                  45              


Val Ile Val Tyr Asn Pro Leu Gly Arg Lys Val Asn Trp Met Val Arg 
    50                  55                  60                  


Leu Pro Val Ser Glu Gly Val Phe Val Val Lys Asp Pro Asn Gly Arg 
65                  70                  75                  80  


Thr Val Pro Ser Asp Leu Arg Gln Pro Gly Ala Pro Ser Gly Ala Ala 
                85                  90                  95      


Val Leu Ser Leu Thr Ala Arg Pro Gly Leu Gln His Leu Phe Ser Ser 
            100                 105                 110         


Pro Gly Ala Ser Leu Glu Ala Pro Gly Pro Arg Thr Thr Ala His Pro 
        115                 120                 125             


Gln Lys Ile Leu Val Pro Cys Phe Asn His Arg Lys 
    130                 135                 140 


<210>  8282
<211>  67
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8282

Xaa Ser Asp Val Val Ile Phe Pro Ser Ser Asp Ser Gln Ala His Pro 
1               5                   10                  15      


Pro Glu Leu Leu Phe Ser Ala Ser Leu Pro Ala Leu Gly Phe Ser Thr 
            20                  25                  30          


Tyr Ser Val Ala Gln Val Pro Arg Trp Lys Pro Gln Ala Arg Ala Pro 
        35                  40                  45              


Gln Pro Ile Pro Arg Arg Ser Trp Ser Pro Ala Leu Thr Ile Glu Asn 
    50                  55                  60                  


Glu Gly Cys 
65          


<210>  8283
<211>  1009
<212>  PRT
<213>  Homo Sapiens

<400>  8283

Met Gly Gln Leu Cys Trp Leu Pro Leu Leu Ala Pro Leu Leu Leu Leu 
1               5                   10                  15      


Arg Pro Pro Gly Val Gln Ser Ala Gly Pro Ile Arg Ala Phe Val Val 
            20                  25                  30          


Pro His Ser His Met Asp Val Gly Trp Val Tyr Thr Val Gln Glu Ser 
        35                  40                  45              


Met Arg Ala Tyr Ala Ala Asn Val Tyr Thr Ser Val Val Glu Glu Leu 
    50                  55                  60                  


Ala Arg Gly Gln Gln Arg Arg Phe Ile Ala Val Glu Gln Glu Phe Phe 
65                  70                  75                  80  


Arg Leu Trp Trp Asp Gly Val Ala Ser Asp Gln Gln Lys Tyr Gln Val 
                85                  90                  95      


Arg Gln Leu Leu Glu Glu Gly Arg Leu Glu Phe Val Ile Gly Gly Gln 
            100                 105                 110         


Val Met His Asp Glu Ala Val Thr His Leu Asp Asp Gln Ile Leu Gln 
        115                 120                 125             


Leu Thr Glu Gly His Gly Phe Leu Tyr Glu Thr Phe Gly Ile Arg Pro 
    130                 135                 140                 


Gln Phe Ser Trp His Val Asp Pro Phe Gly Ala Ser Ala Thr Thr Pro 
145                 150                 155                 160 


Thr Leu Phe Ala Leu Ala Gly Phe Asn Ala His Leu Gly Ser Arg Ile 
                165                 170                 175     


Asp Tyr Asp Leu Lys Ala Ala Met Gln Glu Ala Arg Gly Leu Gln Phe 
            180                 185                 190         


Val Trp Arg Gly Ser Pro Ser Leu Ser Glu Arg Gln Glu Ile Phe Thr 
        195                 200                 205             


His Ile Met Asp Gln Tyr Ser Tyr Cys Thr Pro Ser His Ile Pro Phe 
    210                 215                 220                 


Ser Asn Arg Ser Gly Phe Tyr Trp Asn Gly Val Ala Val Phe Pro Lys 
225                 230                 235                 240 


Pro Pro Gln Asp Gly Val Tyr Pro Asn Met Ser Glu Pro Val Thr Pro 
                245                 250                 255     


Ala Asn Ile Asn Leu Tyr Ala Glu Ala Leu Val Ala Asn Val Lys Gln 
            260                 265                 270         


Arg Ala Ala Trp Phe Arg Thr Pro His Val Leu Trp Pro Trp Gly Cys 
        275                 280                 285             


Asp Lys Gln Phe Phe Asn Ala Ser Val Gln Phe Ala Asn Met Asp Pro 
    290                 295                 300                 


Leu Leu Asp His Ile Asn Ser His Ala Ala Glu Leu Gly Val Ser Val 
305                 310                 315                 320 


Gln Tyr Ala Thr Leu Gly Asp Tyr Phe Arg Ala Leu His Ala Leu Asn 
                325                 330                 335     


Val Thr Trp Arg Val Arg Asp His His Asp Phe Leu Pro Tyr Ser Thr 
            340                 345                 350         


Glu Pro Phe Gln Ala Trp Thr Gly Phe Tyr Thr Ser Arg Ser Ser Leu 
        355                 360                 365             


Lys Gly Leu Ala Arg Arg Ala Ser Ala Leu Leu Tyr Ala Gly Glu Ser 
    370                 375                 380                 


Met Phe Thr Arg Tyr Leu Trp Pro Ala Pro Arg Gly His Leu Asp Pro 
385                 390                 395                 400 


Thr Trp Ala Leu Gln Gln Leu Gln Gln Leu Arg Trp Ala Val Ser Glu 
                405                 410                 415     


Val Gln His His Asp Ala Ile Thr Gly Thr Glu Ser Pro Lys Val Arg 
            420                 425                 430         


Asp Met Tyr Ala Thr His Leu Ala Ser Gly Met Leu Gly Met Arg Lys 
        435                 440                 445             


Leu Met Ala Ser Ile Val Leu Asp Glu Leu Gln Pro Gln Ala Pro Met 
    450                 455                 460                 


Ala Ala Ser Ser Asp Ala Gly Pro Ala Gly His Phe Ala Ser Val Tyr 
465                 470                 475                 480 


Asn Pro Leu Ala Trp Thr Val Thr Thr Ile Val Thr Leu Thr Val Gly 
                485                 490                 495     


Phe Pro Gly Val Arg Val Thr Asp Glu Ala Gly His Pro Val Pro Ser 
            500                 505                 510         


Gln Ile Gln Asn Ser Thr Glu Thr Pro Ser Ala Tyr Asp Leu Leu Ile 
        515                 520                 525             


Leu Thr Thr Ile Pro Gly Leu Ser Tyr Arg His Tyr Asn Ile Arg Pro 
    530                 535                 540                 


Thr Ala Gly Ala Gln Glu Gly Thr Gln Glu Pro Ala Ala Thr Val Ala 
545                 550                 555                 560 


Ser Thr Leu Gln Phe Gly Arg Arg Leu Arg Arg Arg Thr Ser His Ala 
                565                 570                 575     


Gly Arg Tyr Leu Val Pro Val Ala Asn Asp Cys Tyr Ile Val Leu Leu 
            580                 585                 590         


Asp Gln Asp Thr Asn Leu Met His Ser Ile Trp Glu Arg Gln Ser Asn 
        595                 600                 605             


Arg Thr Val Arg Val Thr Gln Glu Phe Leu Glu Tyr His Val Asn Gly 
    610                 615                 620                 


Asp Val Lys Gln Gly Pro Ile Ser Asp Asn Tyr Leu Phe Thr Pro Gly 
625                 630                 635                 640 


Lys Ala Ala Val Pro Ala Trp Glu Ala Val Glu Met Glu Ile Val Ala 
                645                 650                 655     


Gly Gln Leu Val Thr Glu Ile Arg Gln Tyr Phe Tyr Arg Asn Met Thr 
            660                 665                 670         


Ala Gln Asn Tyr Thr Tyr Ala Ile Arg Ser Arg Leu Thr His Val Pro 
        675                 680                 685             


Gln Gly His Asp Gly Glu Leu Leu Cys His Arg Ile Glu Gln Glu Tyr 
    690                 695                 700                 


Gln Ala Gly Pro Leu Glu Leu Asn Arg Glu Ala Val Leu Arg Thr Ser 
705                 710                 715                 720 


Thr Asn Leu Asn Ser Gln Gln Val Ile Tyr Ser Asp Asn Asn Gly Tyr 
                725                 730                 735     


Gln Met Gln Arg Arg Pro Tyr Val Ser Tyr Val Asn Asn Ser Ile Ala 
            740                 745                 750         


Arg Asn Tyr Tyr Pro Met Val Gln Ser Ala Phe Met Glu Asp Gly Lys 
        755                 760                 765             


Ser Arg Leu Val Leu Leu Ser Glu Arg Ala His Gly Ile Ser Ser Gln 
    770                 775                 780                 


Gly Asn Gly Gln Val Glu Val Met Leu His Arg Arg Leu Trp Asn Asn 
785                 790                 795                 800 


Phe Asp Trp Asp Leu Gly Tyr Asn Leu Thr Leu Asn Asp Thr Ser Val 
                805                 810                 815     


Val His Pro Val Leu Trp Leu Leu Leu Gly Ser Trp Ser Leu Thr Thr 
            820                 825                 830         


Ala Leu Arg Gln Arg Ser Ala Leu Ala Leu Gln His Arg Pro Val Val 
        835                 840                 845             


Leu Phe Gly Asp Leu Ala Gly Thr Ala Pro Lys Leu Pro Gly Pro Gln 
    850                 855                 860                 


Gln Gln Glu Ala Val Thr Leu Pro Pro Asn Leu His Leu Gln Ile Leu 
865                 870                 875                 880 


Ser Ile Pro Gly Trp Arg Tyr Ser Ser Asn His Thr Glu His Ser Gln 
                885                 890                 895     


Asn Leu Arg Lys Gly His Arg Gly Glu Ala Gln Ala Asp Leu Arg Arg 
            900                 905                 910         


Val Leu Leu Arg Leu Tyr His Leu Tyr Glu Val Gly Glu Asp Pro Val 
        915                 920                 925             


Leu Ser Gln Pro Val Thr Val Asn Leu Glu Ala Val Leu Gln Ala Leu 
    930                 935                 940                 


Gly Ser Val Val Ala Val Glu Glu Arg Ser Leu Thr Gly Thr Trp Asp 
945                 950                 955                 960 


Leu Ser Met Leu His Arg Trp Ser Trp Arg Thr Gly Pro Gly Arg His 
                965                 970                 975     


Arg Gly Asp Thr Thr Ser Pro Ser Arg Pro Pro Gly Gly Pro Ile Ile 
            980                 985                 990         


Thr Val His Pro Lys Glu Ile Arg  Thr Phe Phe Ile His  Phe Gln Gln 
        995                 1000                 1005             


Gln 
    


<210>  8284
<211>  958
<212>  PRT
<213>  Homo Sapiens

<400>  8284

Met Gly Gln Leu Cys Trp Leu Pro Leu Leu Ala Pro Leu Leu Leu Leu 
1               5                   10                  15      


Arg Pro Pro Gly Val Gln Ser Ala Gly Pro Ile Arg Ala Phe Val Val 
            20                  25                  30          


Pro His Ser His Met Asp Val Gly Trp Val Tyr Thr Val Gln Glu Ser 
        35                  40                  45              


Met Arg Ala Tyr Ala Ala Asn Val Tyr Thr Ser Val Val Glu Glu Leu 
    50                  55                  60                  


Ala Arg Gly Gln Gln Arg Arg Phe Ile Ala Val Glu Gln Glu Phe Phe 
65                  70                  75                  80  


Arg Leu Trp Trp Asp Gly Val Ala Ser Asp Gln Gln Lys Tyr Gln Val 
                85                  90                  95      


Arg Gln Leu Leu Glu Glu Gly Arg Leu Glu Phe Val Ile Gly Gly Gln 
            100                 105                 110         


Val Met His Asp Glu Ala Val Thr His Leu Asp Asp Gln Ile Leu Gln 
        115                 120                 125             


Leu Thr Glu Gly His Gly Phe Leu Tyr Glu Thr Phe Gly Ile Arg Pro 
    130                 135                 140                 


Gln Phe Ser Trp His Val Asp Pro Phe Gly Ala Ser Ala Thr Thr Pro 
145                 150                 155                 160 


Thr Leu Phe Ala Leu Ala Gly Phe Asn Ala His Leu Gly Ser Arg Ile 
                165                 170                 175     


Asp Tyr Asp Leu Lys Ala Ala Met Gln Glu Ala Arg Gly Leu Gln Phe 
            180                 185                 190         


Val Trp Arg Gly Ser Pro Ser Leu Ser Glu Arg Gln Glu Ile Phe Thr 
        195                 200                 205             


His Ile Met Asp Gln Tyr Ser Tyr Cys Thr Pro Ser His Ile Pro Phe 
    210                 215                 220                 


Ser Asn Arg Ser Gly Phe Tyr Trp Asn Gly Val Ala Val Phe Pro Lys 
225                 230                 235                 240 


Pro Pro Gln Asp Gly Val Tyr Pro Asn Met Ser Glu Pro Val Thr Pro 
                245                 250                 255     


Ala Asn Ile Asn Leu Tyr Ala Glu Leu Gly Val Ser Val Gln Tyr Ala 
            260                 265                 270         


Thr Leu Gly Asp Tyr Phe Arg Ala Leu His Ala Leu Asn Val Thr Trp 
        275                 280                 285             


Arg Val Arg Asp His His Asp Phe Leu Pro Tyr Ser Thr Glu Pro Phe 
    290                 295                 300                 


Gln Ala Trp Thr Gly Phe Tyr Thr Ser Arg Ser Ser Leu Lys Gly Leu 
305                 310                 315                 320 


Ala Arg Arg Ala Ser Ala Leu Leu Tyr Ala Gly Glu Ser Met Phe Thr 
                325                 330                 335     


Arg Tyr Leu Trp Pro Ala Pro Arg Gly His Leu Asp Pro Thr Trp Ala 
            340                 345                 350         


Leu Gln Gln Leu Gln Gln Leu Arg Trp Ala Val Ser Glu Val Gln His 
        355                 360                 365             


His Asp Ala Ile Thr Gly Thr Glu Ser Pro Lys Val Arg Asp Met Tyr 
    370                 375                 380                 


Ala Thr His Leu Ala Ser Gly Met Leu Gly Met Arg Lys Leu Met Ala 
385                 390                 395                 400 


Ser Ile Val Leu Asp Glu Leu Gln Pro Gln Ala Pro Met Ala Ala Ser 
                405                 410                 415     


Ser Asp Ala Gly Pro Ala Gly His Phe Ala Ser Val Tyr Asn Pro Leu 
            420                 425                 430         


Ala Trp Thr Val Thr Thr Ile Val Thr Leu Thr Val Gly Phe Pro Gly 
        435                 440                 445             


Val Arg Val Thr Asp Glu Ala Gly His Pro Val Pro Ser Gln Ile Gln 
    450                 455                 460                 


Asn Ser Thr Glu Thr Pro Ser Ala Tyr Asp Leu Leu Ile Leu Thr Thr 
465                 470                 475                 480 


Ile Pro Gly Leu Ser Tyr Arg His Tyr Asn Ile Arg Pro Thr Ala Gly 
                485                 490                 495     


Ala Gln Glu Gly Thr Gln Glu Pro Ala Ala Thr Val Ala Ser Thr Leu 
            500                 505                 510         


Gln Phe Gly Arg Arg Leu Arg Arg Arg Thr Ser His Ala Gly Arg Tyr 
        515                 520                 525             


Leu Val Pro Val Ala Asn Asp Cys Tyr Ile Val Leu Leu Asp Gln Asp 
    530                 535                 540                 


Thr Asn Leu Met His Ser Ile Trp Glu Arg Gln Ser Asn Arg Thr Val 
545                 550                 555                 560 


Arg Val Thr Gln Glu Phe Leu Glu Tyr His Val Asn Gly Asp Val Lys 
                565                 570                 575     


Gln Gly Pro Ile Ser Asp Asn Tyr Leu Phe Thr Pro Gly Lys Ala Ala 
            580                 585                 590         


Val Pro Ala Trp Glu Ala Val Glu Met Glu Ile Val Ala Gly Gln Leu 
        595                 600                 605             


Val Thr Glu Ile Arg Gln Tyr Phe Tyr Arg Asn Met Thr Ala Gln Asn 
    610                 615                 620                 


Tyr Thr Tyr Ala Ile Arg Ser Arg Leu Thr His Val Pro Gln Gly His 
625                 630                 635                 640 


Asp Gly Glu Leu Leu Cys His Arg Ile Glu Gln Glu Tyr Gln Ala Gly 
                645                 650                 655     


Pro Leu Glu Leu Asn Arg Glu Ala Val Leu Arg Thr Ser Thr Asn Leu 
            660                 665                 670         


Asn Ser Gln Gln Val Ile Tyr Ser Asp Asn Asn Gly Tyr Gln Met Gln 
        675                 680                 685             


Arg Arg Pro Tyr Val Ser Tyr Val Asn Asn Ser Ile Ala Arg Asn Tyr 
    690                 695                 700                 


Tyr Pro Met Val Gln Ser Ala Phe Met Glu Asp Gly Lys Ser Arg Leu 
705                 710                 715                 720 


Val Leu Leu Ser Glu Arg Ala His Gly Ile Ser Ser Gln Gly Asn Gly 
                725                 730                 735     


Gln Val Glu Val Met Leu His Arg Arg Leu Trp Asn Asn Phe Asp Trp 
            740                 745                 750         


Asp Leu Gly Tyr Asn Leu Thr Leu Asn Asp Thr Ser Val Val His Pro 
        755                 760                 765             


Val Leu Trp Leu Leu Leu Gly Ser Trp Ser Leu Thr Thr Ala Leu Arg 
    770                 775                 780                 


Gln Arg Ser Ala Leu Ala Leu Gln His Arg Pro Val Val Leu Phe Gly 
785                 790                 795                 800 


Asp Leu Ala Gly Thr Ala Pro Lys Leu Pro Gly Pro Gln Gln Gln Glu 
                805                 810                 815     


Ala Val Thr Leu Pro Pro Asn Leu His Leu Gln Ile Leu Ser Ile Pro 
            820                 825                 830         


Gly Trp Arg Tyr Ser Ser Asn His Thr Glu His Ser Gln Asn Leu Arg 
        835                 840                 845             


Lys Gly His Arg Gly Glu Ala Gln Ala Asp Leu Arg Arg Val Leu Leu 
    850                 855                 860                 


Arg Leu Tyr His Leu Tyr Glu Val Gly Glu Asp Pro Val Leu Ser Gln 
865                 870                 875                 880 


Pro Val Thr Val Asn Leu Glu Ala Val Leu Gln Ala Leu Gly Ser Val 
                885                 890                 895     


Val Ala Val Glu Glu Arg Ser Leu Thr Gly Thr Trp Asp Leu Ser Met 
            900                 905                 910         


Leu His Arg Trp Ser Trp Arg Thr Gly Pro Gly Arg His Arg Gly Asp 
        915                 920                 925             


Thr Thr Ser Pro Ser Arg Pro Pro Gly Gly Pro Ile Ile Thr Val His 
    930                 935                 940                 


Pro Lys Glu Ile Arg Thr Phe Phe Ile His Phe Gln Gln Gln 
945                 950                 955             


<210>  8285
<211>  953
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8285

Xaa Gln Leu Cys Trp Leu Pro Leu Leu Ala Pro Leu Leu Leu Leu Arg 
1               5                   10                  15      


Pro Pro Gly Val Gln Ser Ala Gly Pro Ile Arg Ala Phe Val Val Pro 
            20                  25                  30          


His Ser His Met Asp Val Gly Trp Val Tyr Thr Val Gln Glu Ser Met 
        35                  40                  45              


Arg Ala Tyr Ala Ala Asn Val Tyr Thr Ser Val Val Glu Glu Leu Ala 
    50                  55                  60                  


Arg Gly Gln Gln Arg Arg Phe Ile Ala Val Glu Gln Glu Phe Phe Arg 
65                  70                  75                  80  


Leu Trp Trp Asp Gly Val Ala Ser Asp Gln Gln Lys Tyr Gln Val Arg 
                85                  90                  95      


Gln Leu Leu Glu Glu Gly Arg Leu Glu Phe Val Ile Gly Gly Gln Val 
            100                 105                 110         


Met His Asp Glu Ala Val Thr His Leu Asp Asp Gln Ile Leu Gln Leu 
        115                 120                 125             


Thr Glu Gly His Gly Phe Leu Tyr Glu Thr Phe Gly Ile Arg Pro Gln 
    130                 135                 140                 


Phe Ser Trp His Val Asp Pro Phe Gly Ala Ser Ala Thr Thr Pro Thr 
145                 150                 155                 160 


Leu Phe Ala Leu Ala Gly Phe Asn Ala His Leu Gly Ser Arg Ile Asp 
                165                 170                 175     


Tyr Asp Leu Lys Ala Ala Met Gln Glu Ala Arg Gly Leu Gln Phe Val 
            180                 185                 190         


Trp Arg Gly Ser Pro Ser Leu Ser Glu Arg Gln Glu Ile Phe Thr His 
        195                 200                 205             


Ile Met Asp Gln Tyr Ser Tyr Cys Thr Pro Ser His Ile Pro Phe Ser 
    210                 215                 220                 


Asn Arg Ser Gly Phe Tyr Trp Asn Gly Val Ala Val Phe Pro Lys Pro 
225                 230                 235                 240 


Pro Gln Asp Gly Val Tyr Pro Asn Met Ser Glu Pro Val Thr Pro Ala 
                245                 250                 255     


Asn Ile Asn Leu Tyr Ala Glu Ala Leu Val Ala Asn Val Lys Gln Arg 
            260                 265                 270         


Ala Ala Trp Phe Arg Thr Pro His Val Leu Trp Pro Trp Gly Cys Asp 
        275                 280                 285             


Lys Gln Phe Phe Asn Ala Ser Val Gln Phe Ala Asn Met Asp Pro Leu 
    290                 295                 300                 


Leu Asp His Ile Asn Ser His Ala Ala Glu Leu Gly Val Ser Val Gln 
305                 310                 315                 320 


Tyr Ala Thr Leu Gly Asp Tyr Phe Arg Ala Leu His Ala Leu Asn Val 
                325                 330                 335     


Thr Trp Arg Val Arg Asp His His Asp Phe Leu Pro Tyr Ser Thr Glu 
            340                 345                 350         


Pro Phe Gln Ala Trp Thr Gly Phe Tyr Thr Ser Arg Ser Ser Leu Lys 
        355                 360                 365             


Gly Leu Ala Arg Arg Ala Ser Ala Leu Leu Tyr Ala Gly Glu Ser Met 
    370                 375                 380                 


Phe Thr Arg Tyr Leu Trp Pro Ala Pro Arg Gly His Leu Asp Pro Thr 
385                 390                 395                 400 


Trp Ala Leu Gln Gln Leu Gln Gln Leu Arg Trp Ala Val Ser Glu Val 
                405                 410                 415     


Gln His His Asp Ala Ile Thr Gly Thr Glu Ser Pro Lys Val Arg Asp 
            420                 425                 430         


Met Tyr Ala Thr His Leu Ala Ser Gly Met Leu Gly Met Arg Lys Leu 
        435                 440                 445             


Met Ala Ser Ile Val Leu Asp Glu Leu Gln Pro Gln Ala Pro Met Ala 
    450                 455                 460                 


Ala Ser Ser Asp Ala Gly Pro Ala Gly His Phe Ala Ser Val Tyr Asn 
465                 470                 475                 480 


Pro Leu Ala Trp Thr Val Thr Thr Ile Val Thr Leu Thr Val Gly Phe 
                485                 490                 495     


Pro Gly Val Arg Val Thr Asp Glu Ala Gly His Pro Val Pro Ser Gln 
            500                 505                 510         


Ile Gln Asn Ser Thr Glu Thr Pro Ser Ala Tyr Asp Leu Leu Ile Leu 
        515                 520                 525             


Thr Thr Ile Pro Gly Leu Ser Tyr Arg His Tyr Asn Ile Arg Pro Thr 
    530                 535                 540                 


Ala Gly Ala Gln Glu Gly Thr Gln Glu Pro Ala Ala Thr Val Ala Ser 
545                 550                 555                 560 


Thr Leu Gln Phe Gly Arg Arg Leu Arg Arg Arg Thr Ser His Ala Gly 
                565                 570                 575     


Arg Tyr Leu Val Pro Val Ala Asn Asp Cys Tyr Ile Val Leu Leu Asp 
            580                 585                 590         


Gln Asp Thr Asn Leu Met His Ser Ile Trp Glu Arg Gln Ser Asn Arg 
        595                 600                 605             


Thr Val Arg Val Thr Gln Glu Phe Leu Glu Tyr His Val Asn Gly Asp 
    610                 615                 620                 


Val Lys Gln Gly Pro Ile Ser Asp Asn Tyr Leu Phe Thr Pro Gly Lys 
625                 630                 635                 640 


Ala Ala Val Pro Ala Trp Glu Ala Val Glu Met Glu Ile Val Ala Gly 
                645                 650                 655     


Gln Leu Val Thr Glu Ile Arg Gln Tyr Phe Tyr Arg Asn Met Thr Ala 
            660                 665                 670         


Gln Asn Tyr Thr Tyr Ala Ile Arg Ser Arg Leu Thr His Val Pro Gln 
        675                 680                 685             


Gly His Asp Gly Glu Leu Leu Cys His Arg Ile Glu Gln Glu Tyr Gln 
    690                 695                 700                 


Ala Gly Pro Leu Glu Leu Asn Arg Glu Ala Val Leu Arg Thr Ser Thr 
705                 710                 715                 720 


Asn Leu Asn Ser Gln Gln Val Ile Tyr Ser Asp Asn Asn Gly Tyr Gln 
                725                 730                 735     


Met Gln Arg Arg Pro Tyr Val Ser Tyr Val Asn Asn Ser Ile Ala Arg 
            740                 745                 750         


Asn Tyr Tyr Pro Met Val Gln Ser Ala Phe Met Glu Asp Gly Lys Ser 
        755                 760                 765             


Arg Leu Val Leu Leu Ser Glu Arg Ala His Gly Ile Ser Ser Gln Gly 
    770                 775                 780                 


Asn Gly Gln Val Glu Val Met Leu His Arg Arg Leu Trp Asn Asn Phe 
785                 790                 795                 800 


Asp Trp Asp Leu Gly Tyr Asn Leu Thr Leu Asn Asp Thr Ser Val Val 
                805                 810                 815     


His Pro Val Leu Trp Leu Leu Leu Gly Ser Trp Ser Leu Thr Thr Ala 
            820                 825                 830         


Leu Arg Gln Arg Ser Ala Leu Ala Leu Gln His Arg Pro Val Val Leu 
        835                 840                 845             


Phe Gly Asp Leu Ala Gly Thr Ala Pro Lys Leu Pro Gly Pro Gln Gln 
    850                 855                 860                 


Gln Glu Ala Val Thr Leu Pro Pro Asn Leu His Leu Gln Ile Leu Ser 
865                 870                 875                 880 


Ile Pro Gly Trp Arg Tyr Ser Ser Asn His Thr Glu His Ser Gln Asn 
                885                 890                 895     


Leu Arg Lys Gly His Arg Gly Glu Ala Gln Ala Asp Leu Arg Arg Val 
            900                 905                 910         


Leu Leu Arg Leu Tyr His Leu Tyr Glu Val Gly Glu Asp Pro Val Leu 
        915                 920                 925             


Ser Gln Pro Val Thr Val Asn Leu Glu Val Asn Phe Pro Thr Pro Ile 
    930                 935                 940                 


Gln Thr Ile Ser Gln Gly Ser Lys Pro 
945                 950             


<210>  8286
<211>  822
<212>  PRT
<213>  Homo Sapiens

<400>  8286

Met Arg Leu His Leu Leu Leu Leu Leu Ala Leu Cys Gly Ala Gly Thr 
1               5                   10                  15      


Thr Ala Ala Glu Leu Ser Tyr Ser Leu Arg Gly Asn Trp Ser Ile Cys 
            20                  25                  30          


Asn Gly Asn Gly Ser Leu Glu Leu Pro Gly Ala Val Pro Gly Cys Val 
        35                  40                  45              


His Ser Ala Leu Phe Gln Gln Gly Leu Ile Gln Asp Ser Tyr Tyr Arg 
    50                  55                  60                  


Phe Asn Asp Leu Asn Tyr Arg Trp Val Ser Leu Asp Asn Trp Thr Tyr 
65                  70                  75                  80  


Ser Lys Glu Phe Lys Ile Pro Phe Glu Ile Ser Lys Trp Gln Lys Val 
                85                  90                  95      


Asn Leu Ile Leu Glu Gly Val Asp Thr Val Ser Lys Ile Leu Phe Asn 
            100                 105                 110         


Glu Val Thr Ile Gly Glu Thr Asp Asn Met Phe Asn Arg Tyr Glu Gln 
        115                 120                 125             


Cys Ser Phe Ser Trp Asp Trp Gly Pro Ser Phe Pro Thr Gln Gly Ile 
    130                 135                 140                 


Trp Lys Asp Val Arg Ile Glu Ala Tyr Asn Ile Cys His Leu Asn Tyr 
145                 150                 155                 160 


Phe Thr Phe Ser Pro Ile Tyr Asp Lys Ser Ala Gln Glu Trp Asn Leu 
                165                 170                 175     


Glu Ile Glu Ser Thr Phe Asp Val Val Ser Ser Lys Pro Val Gly Gly 
            180                 185                 190         


Gln Val Ile Val Ala Ile Pro Lys Leu Gln Thr Gln Gln Thr Tyr Ser 
        195                 200                 205             


Ile Glu Leu Gln Pro Gly Lys Arg Ile Val Glu Leu Phe Val Asn Ile 
    210                 215                 220                 


Ser Lys Asn Ile Thr Val Glu Thr Trp Trp Pro His Gly His Gly Asn 
225                 230                 235                 240 


Gln Thr Gly Tyr Asn Met Thr Val Leu Phe Glu Leu Asp Gly Gly Leu 
                245                 250                 255     


Asn Ile Glu Lys Ser Ala Lys Val Tyr Phe Arg Thr Val Glu Leu Ile 
            260                 265                 270         


Glu Glu Pro Ile Lys Gly Ser Pro Gly Leu Ser Phe Tyr Phe Lys Ile 
        275                 280                 285             


Asn Gly Phe Pro Ile Phe Leu Lys Gly Ser Asn Trp Ile Pro Ala Asp 
    290                 295                 300                 


Ser Phe Gln Asp Arg Val Thr Ser Glu Leu Leu Arg Leu Leu Leu Gln 
305                 310                 315                 320 


Ser Val Val Asp Ala Asn Met Asn Thr Leu Arg Val Trp Gly Gly Gly 
                325                 330                 335     


Ile Tyr Glu Gln Asp Glu Phe Tyr Glu Leu Cys Asp Glu Leu Gly Ile 
            340                 345                 350         


Met Val Trp Gln Asp Phe Met Phe Ala Cys Ala Leu Tyr Pro Thr Asp 
        355                 360                 365             


Gln Gly Phe Leu Asp Ser Val Thr Ala Glu Val Ala Tyr Gln Ile Lys 
    370                 375                 380                 


Arg Leu Lys Ser His Pro Ser Ile Ile Ile Trp Ser Gly Asn Asn Glu 
385                 390                 395                 400 


Asn Glu Glu Ala Leu Met Met Asn Trp Tyr His Ile Ser Phe Thr Asp 
                405                 410                 415     


Arg Pro Ile Tyr Ile Lys Asp Tyr Val Thr Leu Tyr Val Lys Asn Ile 
            420                 425                 430         


Arg Glu Leu Val Leu Ala Gly Asp Lys Ser Arg Pro Phe Ile Thr Ser 
        435                 440                 445             


Ser Pro Thr Asn Gly Ala Glu Thr Val Ala Glu Ala Trp Val Ser Gln 
    450                 455                 460                 


Asn Pro Asn Ser Asn Tyr Phe Gly Asp Val His Phe Tyr Asp Tyr Ile 
465                 470                 475                 480 


Ser Asp Cys Trp Asn Trp Lys Val Phe Pro Lys Ala Arg Phe Ala Ser 
                485                 490                 495     


Glu Tyr Gly Tyr Gln Ser Trp Pro Ser Phe Ser Thr Leu Glu Lys Val 
            500                 505                 510         


Ser Ser Thr Glu Asp Trp Ser Phe Asn Ser Lys Phe Ser Leu His Arg 
        515                 520                 525             


Gln His His Glu Gly Gly Asn Lys Gln Met Leu Tyr Gln Ala Gly Leu 
    530                 535                 540                 


His Phe Lys Leu Pro Gln Ser Thr Asp Pro Leu Arg Thr Phe Lys Asp 
545                 550                 555                 560 


Thr Ile Tyr Leu Thr Gln Val Met Gln Ala Gln Cys Val Lys Thr Glu 
                565                 570                 575     


Thr Glu Phe Tyr Arg Arg Ser Arg Ser Glu Ile Val Asp Gln Gln Gly 
            580                 585                 590         


His Thr Met Gly Ala Leu Tyr Trp Gln Leu Asn Asp Ile Trp Gln Ala 
        595                 600                 605             


Pro Ser Trp Ala Ser Leu Glu Tyr Gly Gly Lys Trp Lys Met Leu His 
    610                 615                 620                 


Tyr Phe Ala Gln Asn Phe Phe Ala Pro Leu Leu Pro Val Gly Phe Glu 
625                 630                 635                 640 


Asn Glu Asn Thr Phe Tyr Ile Tyr Gly Val Ser Asp Leu His Ser Asp 
                645                 650                 655     


Tyr Ser Met Thr Leu Ser Val Arg Val His Thr Trp Ser Ser Leu Glu 
            660                 665                 670         


Pro Val Cys Ser Arg Val Thr Glu Arg Phe Val Met Lys Gly Gly Glu 
        675                 680                 685             


Ala Val Cys Leu Tyr Glu Glu Pro Val Ser Glu Leu Leu Arg Arg Cys 
    690                 695                 700                 


Gly Asn Cys Thr Arg Glu Ser Cys Val Val Ser Phe Tyr Leu Ser Ala 
705                 710                 715                 720 


Asp His Glu Leu Leu Ser Pro Thr Asn Tyr His Phe Leu Ser Ser Pro 
                725                 730                 735     


Lys Glu Ala Val Gly Leu Cys Lys Ala Gln Ile Thr Ala Ile Ile Ser 
            740                 745                 750         


Gln Gln Gly Asp Ile Phe Val Phe Asp Leu Glu Thr Ser Ala Val Ala 
        755                 760                 765             


Pro Phe Val Trp Leu Asp Val Gly Ser Ile Pro Gly Arg Phe Ser Asp 
    770                 775                 780                 


Asn Gly Phe Leu Met Thr Glu Lys Thr Arg Thr Ile Leu Phe Tyr Pro 
785                 790                 795                 800 


Trp Glu Pro Thr Ser Lys Asn Glu Leu Glu Gln Ser Phe His Val Thr 
                805                 810                 815     


Ser Leu Thr Asp Ile Tyr 
            820         


<210>  8287
<211>  879
<212>  PRT
<213>  Homo Sapiens

<400>  8287

Met Arg Leu His Leu Leu Leu Leu Leu Ala Leu Cys Gly Ala Gly Thr 
1               5                   10                  15      


Thr Ala Ala Glu Leu Ser Tyr Ser Leu Arg Gly Asn Trp Ser Ile Cys 
            20                  25                  30          


Asn Gly Asn Gly Ser Leu Glu Leu Pro Gly Ala Val Pro Gly Cys Val 
        35                  40                  45              


His Ser Ala Leu Phe Gln Gln Gly Leu Ile Gln Asp Ser Tyr Tyr Arg 
    50                  55                  60                  


Phe Asn Asp Leu Asn Tyr Arg Trp Val Ser Leu Asp Asn Trp Thr Tyr 
65                  70                  75                  80  


Ser Lys Glu Phe Lys Ile Pro Phe Glu Ile Ser Lys Trp Gln Lys Val 
                85                  90                  95      


Asn Leu Ile Leu Glu Gly Val Asp Thr Val Ser Lys Ile Leu Phe Asn 
            100                 105                 110         


Glu Val Thr Ile Gly Glu Thr Asp Asn Met Phe Asn Arg Tyr Ser Phe 
        115                 120                 125             


Asp Ile Thr Asn Val Val Arg Asp Val Asn Ser Ile Glu Leu Arg Phe 
    130                 135                 140                 


Gln Ser Ala Val Leu Tyr Ala Ala Gln Gln Ser Lys Ala His Thr Arg 
145                 150                 155                 160 


Tyr Gln Val Pro Pro Asp Cys Pro Pro Leu Val Gln Lys Gly Glu Cys 
                165                 170                 175     


His Val Asn Phe Val Arg Lys Glu Gln Cys Ser Phe Ser Trp Asp Trp 
            180                 185                 190         


Gly Pro Ser Phe Pro Thr Gln Gly Ile Trp Lys Asp Val Arg Ile Glu 
        195                 200                 205             


Ala Tyr Asn Ile Cys His Leu Asn Tyr Phe Thr Phe Ser Pro Ile Tyr 
    210                 215                 220                 


Asp Lys Ser Ala Gln Glu Trp Asn Leu Glu Ile Glu Ser Thr Phe Asp 
225                 230                 235                 240 


Val Val Ser Ser Lys Pro Val Gly Gly Gln Val Ile Val Ala Ile Pro 
                245                 250                 255     


Lys Leu Gln Thr Gln Gln Thr Tyr Ser Ile Glu Leu Gln Pro Gly Lys 
            260                 265                 270         


Arg Ile Val Glu Leu Phe Val Asn Ile Ser Lys Asn Ile Thr Val Glu 
        275                 280                 285             


Thr Trp Trp Pro His Gly His Gly Asn Gln Thr Gly Tyr Asn Met Thr 
    290                 295                 300                 


Val Leu Phe Glu Leu Asp Gly Gly Leu Asn Ile Glu Lys Ser Ala Lys 
305                 310                 315                 320 


Val Tyr Phe Arg Thr Val Glu Leu Ile Glu Glu Pro Ile Lys Gly Ser 
                325                 330                 335     


Pro Gly Leu Ser Phe Tyr Phe Lys Ile Asn Gly Phe Pro Ile Phe Leu 
            340                 345                 350         


Lys Gly Ser Asn Trp Ile Pro Ala Asp Ser Phe Gln Asp Arg Val Thr 
        355                 360                 365             


Ser Glu Leu Leu Arg Leu Leu Leu Gln Ser Val Val Asp Ala Asn Met 
    370                 375                 380                 


Asn Thr Leu Arg Val Trp Gly Gly Gly Ile Tyr Glu Gln Asp Glu Phe 
385                 390                 395                 400 


Tyr Glu Leu Cys Asp Glu Leu Gly Ile Met Val Trp Gln Asp Phe Met 
                405                 410                 415     


Phe Ala Cys Ala Leu Tyr Pro Thr Asp Gln Gly Phe Leu Asp Ser Val 
            420                 425                 430         


Thr Ala Glu Val Ala Tyr Gln Ile Lys Arg Leu Lys Ser His Pro Ser 
        435                 440                 445             


Ile Ile Ile Trp Ser Gly Asn Asn Glu Asn Glu Glu Ala Leu Met Met 
    450                 455                 460                 


Asn Trp Tyr His Ile Ser Phe Thr Asp Arg Pro Ile Tyr Ile Lys Asp 
465                 470                 475                 480 


Tyr Val Thr Leu Tyr Val Lys Asn Ile Arg Glu Leu Val Leu Ala Gly 
                485                 490                 495     


Asp Lys Ser Arg Pro Phe Ile Thr Ser Ser Pro Thr Asn Gly Ala Glu 
            500                 505                 510         


Thr Val Ala Glu Ala Trp Val Ser Gln Asn Pro Asn Ser Asn Tyr Phe 
        515                 520                 525             


Gly Asp Val His Phe Tyr Asp Tyr Ile Ser Asp Cys Trp Asn Trp Lys 
    530                 535                 540                 


Val Phe Pro Lys Ala Arg Phe Ala Ser Glu Tyr Gly Tyr Gln Ser Trp 
545                 550                 555                 560 


Pro Ser Phe Ser Thr Leu Glu Lys Val Ser Ser Thr Glu Asp Trp Ser 
                565                 570                 575     


Phe Asn Ser Lys Phe Ser Leu His Arg Gln His His Glu Gly Gly Asn 
            580                 585                 590         


Lys Gln Met Leu Tyr Gln Ala Gly Leu His Phe Lys Leu Pro Gln Ser 
        595                 600                 605             


Thr Asp Pro Leu Arg Thr Phe Lys Asp Thr Ile Tyr Leu Thr Gln Val 
    610                 615                 620                 


Met Gln Ala Gln Cys Val Lys Thr Glu Thr Glu Phe Tyr Arg Arg Ser 
625                 630                 635                 640 


Arg Ser Glu Ile Val Asp Gln Gln Gly His Thr Met Gly Ala Leu Tyr 
                645                 650                 655     


Trp Gln Leu Asn Asp Ile Trp Gln Ala Pro Ser Trp Ala Ser Leu Glu 
            660                 665                 670         


Tyr Gly Gly Lys Trp Lys Met Leu His Tyr Phe Ala Gln Asn Phe Phe 
        675                 680                 685             


Ala Pro Leu Leu Pro Val Gly Phe Glu Asn Glu Asn Thr Phe Tyr Ile 
    690                 695                 700                 


Tyr Gly Val Ser Asp Leu His Ser Asp Tyr Ser Met Thr Leu Ser Val 
705                 710                 715                 720 


Arg Val His Thr Trp Ser Ser Leu Glu Pro Val Cys Ser Arg Val Thr 
                725                 730                 735     


Glu Arg Phe Val Met Lys Gly Gly Glu Ala Val Cys Leu Tyr Glu Glu 
            740                 745                 750         


Pro Val Ser Glu Leu Leu Arg Arg Cys Gly Asn Cys Thr Arg Glu Ser 
        755                 760                 765             


Cys Val Val Ser Phe Tyr Leu Ser Ala Asp His Glu Leu Leu Ser Pro 
    770                 775                 780                 


Thr Asn Tyr His Phe Leu Ser Ser Pro Lys Glu Ala Val Gly Leu Cys 
785                 790                 795                 800 


Lys Ala Gln Ile Thr Ala Ile Ile Ser Gln Gln Gly Asp Ile Phe Val 
                805                 810                 815     


Phe Asp Leu Glu Thr Ser Ala Val Ala Pro Phe Val Trp Leu Asp Val 
            820                 825                 830         


Gly Ser Ile Pro Gly Arg Phe Ser Asp Asn Gly Phe Leu Met Thr Glu 
        835                 840                 845             


Lys Thr Arg Thr Ile Leu Phe Tyr Pro Trp Glu Pro Thr Ser Lys Asn 
    850                 855                 860                 


Glu Leu Glu Gln Ser Phe His Val Thr Ser Leu Thr Asp Ile Tyr 
865                 870                 875                 


<210>  8288
<211>  509
<212>  PRT
<213>  Homo Sapiens

<400>  8288

Met Arg Leu His Leu Leu Leu Leu Leu Ala Leu Cys Gly Ala Gly Thr 
1               5                   10                  15      


Thr Ala Ala Glu Leu Ser Tyr Ser Leu Arg Gly Asn Trp Ser Ile Cys 
            20                  25                  30          


Asn Gly Asn Gly Ser Leu Glu Leu Pro Gly Ala Val Pro Gly Cys Val 
        35                  40                  45              


His Ser Ala Leu Phe Gln Gln Gly Leu Ile Gln Asp Ser Tyr Tyr Arg 
    50                  55                  60                  


Phe Asn Asp Leu Asn Tyr Arg Trp Val Ser Leu Asp Asn Trp Thr Tyr 
65                  70                  75                  80  


Ser Lys Glu Phe Lys Ile Pro Phe Glu Ile Ser Lys Trp Gln Lys Val 
                85                  90                  95      


Asn Leu Ile Leu Glu Gly Val Asp Thr Val Ser Lys Ile Leu Phe Asn 
            100                 105                 110         


Glu Val Thr Ile Gly Glu Thr Asp Asn Met Phe Asn Arg Tyr Ser Phe 
        115                 120                 125             


Asp Ile Thr Asn Val Val Arg Asp Val Asn Ser Ile Glu Leu Arg Phe 
    130                 135                 140                 


Gln Ser Ala Val Leu Tyr Ala Ala Gln Gln Ser Lys Ala His Thr Arg 
145                 150                 155                 160 


Tyr Gln Val Pro Pro Asp Cys Pro Pro Leu Val Gln Lys Gly Glu Cys 
                165                 170                 175     


His Val Asn Phe Val Arg Lys Glu Gln Cys Ser Phe Ser Trp Asp Trp 
            180                 185                 190         


Gly Pro Ser Phe Pro Thr Gln Gly Ile Trp Lys Asp Val Arg Ile Glu 
        195                 200                 205             


Ala Tyr Asn Ile Cys His Leu Asn Tyr Phe Thr Phe Ser Pro Ile Tyr 
    210                 215                 220                 


Asp Lys Ser Ala Gln Glu Trp Asn Leu Glu Ile Glu Ser Thr Phe Asp 
225                 230                 235                 240 


Val Val Ser Ser Lys Pro Val Gly Gly Gln Val Ile Val Ala Ile Pro 
                245                 250                 255     


Lys Leu Gln Thr Gln Gln Thr Tyr Ser Ile Glu Leu Gln Pro Gly Lys 
            260                 265                 270         


Arg Ile Val Glu Leu Phe Val Asn Ile Ser Lys Asn Ile Thr Val Glu 
        275                 280                 285             


Thr Trp Trp Pro His Gly His Gly Asn Gln Thr Gly Tyr Asn Met Thr 
    290                 295                 300                 


Val Leu Phe Glu Leu Asp Gly Gly Leu Asn Ile Glu Lys Ser Ala Lys 
305                 310                 315                 320 


Val Tyr Phe Arg Thr Val Glu Leu Ile Glu Glu Pro Ile Lys Gly Ser 
                325                 330                 335     


Pro Gly Leu Ser Phe Tyr Phe Lys Ile Asn Gly Phe Pro Ile Phe Leu 
            340                 345                 350         


Lys Gly Ser Asn Trp Ile Pro Ala Asp Ser Phe Gln Asp Arg Val Thr 
        355                 360                 365             


Ser Glu Leu Leu Arg Leu Leu Leu Gln Ser Val Val Asp Ala Asn Met 
    370                 375                 380                 


Asn Thr Leu Arg Val Trp Gly Gly Gly Ile Tyr Glu Gln Asp Glu Phe 
385                 390                 395                 400 


Tyr Glu Leu Cys Asp Glu Leu Gly Ile Met Val Trp Gln Asp Phe Met 
                405                 410                 415     


Phe Ala Cys Ala Leu Tyr Pro Thr Asp Gln Gly Phe Leu Asp Ser Val 
            420                 425                 430         


Thr Ala Glu Val Ala Tyr Gln Ile Lys Arg Leu Lys Ser His Pro Ser 
        435                 440                 445             


Ile Ile Ile Trp Ser Gly Asn Asn Glu Asn Glu Glu Ala Leu Met Met 
    450                 455                 460                 


Asn Trp Tyr His Ile Ser Phe Thr Asp Arg Pro Ile Tyr Ile Lys Asp 
465                 470                 475                 480 


Tyr Val Thr Leu Tyr Val Lys Asn Ile Arg Glu Leu Val Leu Ala Cys 
                485                 490                 495     


Gly Lys Met Pro Asp Thr Ile Asp Leu Thr Asn Thr Cys 
            500                 505                 


<210>  8289
<211>  886
<212>  PRT
<213>  Homo Sapiens

<400>  8289

Met Arg Leu His Leu Leu Leu Leu Leu Ala Leu Cys Gly Ala Gly Thr 
1               5                   10                  15      


Thr Ala Ala Glu Leu Ser Tyr Ser Leu Arg Gly Asn Trp Ser Ile Cys 
            20                  25                  30          


Asn Gly Asn Gly Ser Leu Glu Leu Pro Gly Ala Val Pro Gly Cys Val 
        35                  40                  45              


His Ser Ala Leu Phe Gln Gln Gly Leu Ile Gln Asp Ser Tyr Tyr Arg 
    50                  55                  60                  


Phe Asn Asp Leu Asn Tyr Arg Trp Val Ser Leu Asp Asn Trp Thr Tyr 
65                  70                  75                  80  


Ser Lys Glu Phe Lys Ile Pro Phe Glu Ile Ser Lys Trp Gln Lys Val 
                85                  90                  95      


Asn Leu Ile Leu Glu Gly Val Asp Thr Val Ser Lys Ile Leu Phe Asn 
            100                 105                 110         


Glu Val Thr Ile Gly Glu Thr Asp Asn Met Phe Asn Arg Tyr Ser Phe 
        115                 120                 125             


Asp Ile Thr Asn Val Val Arg Asp Val Asn Ser Ile Glu Leu Arg Phe 
    130                 135                 140                 


Gln Ser Ala Val Leu Tyr Ala Ala Gln Gln Ser Lys Ala His Thr Arg 
145                 150                 155                 160 


Tyr Gln Val Pro Pro Asp Cys Pro Pro Leu Val Gln Lys Gly Glu Cys 
                165                 170                 175     


His Val Asn Phe Val Arg Lys Glu Gln Cys Ser Phe Ser Trp Asp Trp 
            180                 185                 190         


Gly Pro Ser Phe Pro Thr Gln Gly Ile Trp Lys Asp Val Arg Ile Glu 
        195                 200                 205             


Ala Tyr Asn Ile Cys His Leu Asn Tyr Phe Thr Phe Ser Pro Ile Tyr 
    210                 215                 220                 


Asp Lys Ser Ala Gln Glu Trp Asn Leu Glu Ile Glu Ser Thr Phe Asp 
225                 230                 235                 240 


Val Val Ser Ser Lys Pro Val Gly Gly Gln Val Ile Val Ala Ile Pro 
                245                 250                 255     


Lys Leu Gln Thr Gln Gln Thr Tyr Ser Ile Glu Leu Gln Pro Gly Lys 
            260                 265                 270         


Arg Ile Val Glu Leu Phe Val Asn Ile Ser Lys Asn Ile Thr Val Glu 
        275                 280                 285             


Thr Trp Trp Pro His Gly His Gly Asn Gln Thr Gly Tyr Asn Met Thr 
    290                 295                 300                 


Val Leu Phe Glu Leu Asp Gly Gly Leu Asn Ile Glu Lys Ser Ala Lys 
305                 310                 315                 320 


Val Tyr Phe Arg Thr Val Glu Leu Ile Glu Glu Pro Ile Lys Gly Ser 
                325                 330                 335     


Pro Gly Leu Ser Phe Tyr Phe Lys Ile Asn Gly Phe Pro Ile Phe Leu 
            340                 345                 350         


Lys Gly Ser Asn Trp Ile Pro Ala Asp Ser Phe Gln Asp Arg Val Thr 
        355                 360                 365             


Ser Glu Leu Leu Arg Leu Leu Leu Gln Ser Val Val Asp Ala Asn Met 
    370                 375                 380                 


Asn Thr Leu Arg Val Trp Gly Gly Gly Ile Tyr Glu Gln Asp Glu Phe 
385                 390                 395                 400 


Tyr Glu Leu Cys Asp Glu Leu Gly Ile Met Val Trp Gln Asp Phe Met 
                405                 410                 415     


Phe Ala Cys Ala Leu Tyr Pro Thr Asp Gln Gly Phe Leu Asp Ser Val 
            420                 425                 430         


Thr Ala Glu Val Ala Tyr Gln Ile Lys Arg Leu Lys Ser His Pro Ser 
        435                 440                 445             


Ile Ile Ile Trp Ser Gly Asn Asn Glu Asn Glu Glu Ala Leu Met Met 
    450                 455                 460                 


Asn Trp Tyr His Ile Ser Phe Thr Asp Arg Pro Ile Tyr Ile Lys Asp 
465                 470                 475                 480 


Tyr Val Thr Leu Tyr Val Lys Asn Ile Arg Glu Leu Val Leu Ala Gly 
                485                 490                 495     


Asp Lys Ser Arg Pro Phe Ile Thr Ser Ser Pro Thr Asn Gly Ala Glu 
            500                 505                 510         


Thr Val Ala Glu Ala Trp Val Ser Gln Asn Pro Asn Ser Asn Tyr Phe 
        515                 520                 525             


Gly Asp Val His Phe Tyr Asp Tyr Ile Ser Asp Cys Trp Asn Trp Lys 
    530                 535                 540                 


Val Phe Pro Lys Ala Arg Phe Ala Ser Glu Tyr Gly Tyr Gln Ser Trp 
545                 550                 555                 560 


Pro Ser Phe Ser Thr Leu Glu Lys Val Ser Ser Thr Glu Asp Trp Ser 
                565                 570                 575     


Phe Asn Ser Lys Phe Ser Leu His Arg Gln His His Glu Gly Gly Asn 
            580                 585                 590         


Lys Gln Met Leu Tyr Gln Ala Gly Leu His Phe Lys Leu Pro Gln Ser 
        595                 600                 605             


Thr Asp Pro Leu Arg Thr Phe Lys Asp Thr Ile Tyr Leu Thr Gln Val 
    610                 615                 620                 


Met Gln Ala Gln Cys Val Lys Thr Glu Thr Glu Phe Tyr Arg Arg Ser 
625                 630                 635                 640 


Arg Ser Glu Ile Val Asp Gln Gln Gly His Thr Met Gly Ala Leu Tyr 
                645                 650                 655     


Trp Gln Leu Asn Asp Ile Trp Gln Ala Pro Ser Trp Ala Ser Leu Glu 
            660                 665                 670         


Tyr Gly Gly Lys Trp Lys Met Leu His Tyr Phe Ala Gln Asn Phe Phe 
        675                 680                 685             


Ala Pro Leu Leu Pro Val Gly Phe Glu Asn Glu Asn Thr Phe Tyr Ile 
    690                 695                 700                 


Tyr Gly Val Ser Asp Leu His Ser Asp Tyr Ser Met Thr Leu Ser Val 
705                 710                 715                 720 


Arg Val His Thr Trp Ser Ser Leu Glu Pro Val Cys Ser Arg Val Thr 
                725                 730                 735     


Glu Arg Phe Val Met Lys Gly Gly Glu Ala Val Cys Leu Tyr Glu Glu 
            740                 745                 750         


Pro Val Ser Glu Leu Leu Arg Arg Cys Gly Asn Cys Thr Arg Glu Ser 
        755                 760                 765             


Cys Val Val Ser Phe Tyr Leu Ser Ala Asp His Glu Leu Leu Ser Pro 
    770                 775                 780                 


Thr Asn Tyr His Phe Leu Ser Ser Pro Lys Glu Ala Val Gly Leu Cys 
785                 790                 795                 800 


Lys Ala Gln Ile Thr Gly Ala Ser Leu Asn Pro Arg Leu Cys Ser Gln 
                805                 810                 815     


Thr Tyr Arg Glu Glu Ile Ser Asn Pro Thr Lys Ile Thr Ser Ile Ser 
            820                 825                 830         


Met Thr Pro Ala Ser Leu Ser Ala Leu Val Leu Glu Gln Gln Lys Leu 
        835                 840                 845             


Met Leu Pro Trp Gln Leu Pro Gly Gln Ala Gly Met Ser Arg Met Asn 
    850                 855                 860                 


Leu Val Pro Val Ala Ala Leu Gly Pro Ser Leu Glu Gln Leu Gly Gly 
865                 870                 875                 880 


His His Leu Ser Ala Arg 
                885     


<210>  8290
<211>  397
<212>  PRT
<213>  Homo Sapiens

<400>  8290

Met Arg Leu His Leu Leu Leu Leu Leu Ala Leu Cys Gly Ala Gly Thr 
1               5                   10                  15      


Thr Ala Ala Glu Leu Ser Tyr Ser Leu Arg Gly Asn Trp Ser Ile Cys 
            20                  25                  30          


Asn Gly Asn Gly Ser Leu Glu Leu Pro Gly Ala Val Pro Gly Cys Val 
        35                  40                  45              


His Ser Ala Leu Phe Gln Gln Gly Leu Ile Gln Asp Ser Tyr Tyr Arg 
    50                  55                  60                  


Phe Asn Asp Leu Asn Tyr Arg Trp Val Ser Leu Asp Asn Trp Thr Tyr 
65                  70                  75                  80  


Ser Lys Glu Phe Lys Ile Pro Phe Glu Ile Ser Lys Trp Gln Lys Val 
                85                  90                  95      


Asn Leu Ile Leu Glu Gly Val Asp Thr Val Ser Lys Ile Leu Phe Asn 
            100                 105                 110         


Glu Val Thr Ile Gly Glu Thr Asp Asn Met Phe Asn Arg Tyr Ser Phe 
        115                 120                 125             


Asp Ile Thr Asn Val Val Arg Asp Val Asn Ser Ile Glu Leu Arg Phe 
    130                 135                 140                 


Gln Ser Ala Val Leu Tyr Ala Ala Gln Gln Ser Lys Ala His Thr Arg 
145                 150                 155                 160 


Tyr Gln Val Pro Pro Asp Cys Pro Pro Leu Val Gln Lys Gly Glu Cys 
                165                 170                 175     


His Val Asn Phe Val Arg Lys Glu Gln Cys Ser Phe Ser Trp Asp Trp 
            180                 185                 190         


Gly Pro Ser Phe Pro Thr Gln Gly Ile Trp Lys Asp Val Arg Ile Glu 
        195                 200                 205             


Ala Tyr Asn Ile Cys His Leu Asn Tyr Phe Thr Phe Ser Pro Ile Tyr 
    210                 215                 220                 


Asp Lys Ser Ala Gln Glu Trp Asn Leu Glu Ile Glu Ser Thr Phe Asp 
225                 230                 235                 240 


Val Val Ser Ser Lys Pro Val Gly Gly Gln Val Ile Val Ala Ile Pro 
                245                 250                 255     


Lys Leu Gln Thr Gln Gln Thr Tyr Ser Ile Glu Leu Gln Pro Gly Lys 
            260                 265                 270         


Arg Ile Val Glu Leu Phe Val Asn Ile Ser Lys Asn Ile Thr Val Glu 
        275                 280                 285             


Thr Trp Trp Pro His Gly His Gly Asn Gln Thr Gly Tyr Asn Met Thr 
    290                 295                 300                 


Val Leu Phe Glu Leu Asp Gly Gly Leu Asn Ile Glu Lys Ser Ala Lys 
305                 310                 315                 320 


Val Tyr Phe Arg Thr Val Glu Leu Ile Glu Glu Pro Ile Lys Gly Ser 
                325                 330                 335     


Pro Gly Leu Ser Phe Tyr Phe Lys Ile Asn Gly Phe Pro Ile Phe Leu 
            340                 345                 350         


Lys Gly Ser Asn Trp Ile Pro Ala Asp Ser Phe Gln Asp Arg Val Thr 
        355                 360                 365             


Ser Glu Phe Trp Gly Trp Val Gly Cys Gly Pro Ser Ala Gln Leu Gly 
    370                 375                 380                 


Gln Leu Val Thr Ala Pro Phe Thr Val Cys Cys Gly Cys 
385                 390                 395         


<210>  8291
<211>  413
<212>  PRT
<213>  Homo Sapiens

<400>  8291

Met Arg Leu His Leu Leu Leu Leu Leu Ala Leu Cys Gly Ala Gly Thr 
1               5                   10                  15      


Thr Ala Ala Glu Leu Ser Tyr Ser Leu Arg Gly Asn Trp Ser Ile Cys 
            20                  25                  30          


Asn Gly Asn Gly Ser Leu Glu Leu Pro Gly Ala Val Pro Gly Cys Val 
        35                  40                  45              


His Ser Ala Leu Phe Gln Gln Gly Leu Ile Gln Asp Ser Tyr Tyr Arg 
    50                  55                  60                  


Phe Asn Asp Leu Asn Tyr Arg Trp Val Ser Leu Asp Asn Trp Thr Tyr 
65                  70                  75                  80  


Ser Lys Glu Phe Lys Ile Pro Phe Glu Ile Ser Lys Trp Gln Lys Val 
                85                  90                  95      


Asn Leu Ile Leu Glu Gly Val Asp Thr Val Ser Lys Ile Leu Phe Asn 
            100                 105                 110         


Glu Val Thr Ile Gly Glu Thr Asp Asn Met Phe Asn Arg Tyr Ser Phe 
        115                 120                 125             


Asp Ile Thr Asn Val Val Arg Asp Val Asn Ser Ile Glu Leu Arg Phe 
    130                 135                 140                 


Gln Ser Ala Val Leu Tyr Ala Ala Gln Gln Ser Lys Ala His Thr Arg 
145                 150                 155                 160 


Tyr Gln Val Pro Pro Asp Cys Pro Pro Leu Val Gln Lys Gly Glu Cys 
                165                 170                 175     


His Val Asn Phe Val Arg Lys Glu Gln Cys Ser Phe Ser Trp Asp Trp 
            180                 185                 190         


Gly Pro Ser Phe Pro Thr Gln Gly Ile Trp Lys Asp Val Arg Ile Glu 
        195                 200                 205             


Ala Tyr Asn Ile Cys His Leu Asn Tyr Phe Thr Phe Ser Pro Ile Tyr 
    210                 215                 220                 


Asp Lys Ser Ala Gln Glu Trp Asn Leu Glu Ile Glu Ser Thr Phe Asp 
225                 230                 235                 240 


Val Val Ser Ser Lys Pro Val Gly Gly Gln Val Ile Val Ala Ile Pro 
                245                 250                 255     


Lys Leu Gln Thr Gln Gln Thr Tyr Ser Ile Glu Leu Gln Pro Gly Lys 
            260                 265                 270         


Arg Ile Val Glu Leu Phe Val Asn Ile Ser Lys Asn Ile Thr Val Glu 
        275                 280                 285             


Thr Trp Trp Pro His Gly His Gly Asn Gln Thr Gly Tyr Asn Met Thr 
    290                 295                 300                 


Val Leu Phe Glu Leu Asp Gly Gly Leu Asn Ile Glu Lys Ser Ala Lys 
305                 310                 315                 320 


Val Tyr Phe Arg Thr Val Glu Leu Ile Glu Glu Pro Ile Lys Gly Ser 
                325                 330                 335     


Pro Gly Leu Ser Phe Tyr Phe Lys Ile Asn Gly Phe Pro Ile Phe Leu 
            340                 345                 350         


Lys Gly Ser Asn Trp Ile Pro Ala Asp Ser Phe Gln Asp Arg Val Thr 
        355                 360                 365             


Ser Glu Leu Leu Arg Leu Leu Leu Gln Ser Val Val Asp Ala Asn Met 
    370                 375                 380                 


Asn Thr Leu Arg Val Trp Gly Gly Gly Ile Tyr Glu Gln Asp Glu Phe 
385                 390                 395                 400 


Tyr Glu Leu Cys Asp Glu Leu Gly Ile Met Val Cys Ile 
                405                 410             


<210>  8292
<211>  879
<212>  PRT
<213>  Homo Sapiens

<400>  8292

Met Arg Leu His Leu Leu Leu Leu Leu Ala Leu Cys Gly Ala Gly Thr 
1               5                   10                  15      


Thr Ala Ala Glu Leu Ser Tyr Ser Leu Arg Gly Asn Trp Ser Ile Cys 
            20                  25                  30          


Asn Gly Asn Gly Ser Leu Glu Leu Pro Gly Ala Val Pro Gly Cys Val 
        35                  40                  45              


His Ser Ala Leu Phe Gln Gln Gly Leu Ile Gln Asp Ser Tyr Tyr Arg 
    50                  55                  60                  


Phe Asn Asp Leu Asn Tyr Arg Trp Val Ser Leu Asp Asn Trp Thr Tyr 
65                  70                  75                  80  


Ser Lys Glu Phe Lys Ile Pro Phe Glu Ile Ser Lys Trp Gln Lys Val 
                85                  90                  95      


Asn Leu Ile Leu Glu Gly Val Asp Thr Val Ser Lys Ile Leu Phe Asn 
            100                 105                 110         


Glu Val Thr Ile Gly Glu Thr Asp Asn Met Phe Asn Arg Tyr Ser Phe 
        115                 120                 125             


Asp Ile Thr Asn Val Val Arg Asp Val Asn Ser Ile Glu Leu Arg Phe 
    130                 135                 140                 


Gln Ser Ala Val Leu Tyr Ala Ala Gln Gln Ser Lys Ala His Thr Arg 
145                 150                 155                 160 


Tyr Gln Val Pro Pro Asp Cys Pro Pro Leu Val Gln Lys Gly Glu Cys 
                165                 170                 175     


His Val Asn Phe Val Arg Lys Glu Gln Cys Ser Phe Ser Trp Asp Trp 
            180                 185                 190         


Gly Pro Ser Phe Pro Thr Gln Gly Ile Trp Lys Asp Val Arg Ile Glu 
        195                 200                 205             


Ala Tyr Asn Ile Cys His Leu Asn Tyr Phe Thr Phe Ser Pro Ile Tyr 
    210                 215                 220                 


Asp Lys Ser Ala Gln Glu Trp Asn Leu Glu Ile Glu Ser Thr Phe Asp 
225                 230                 235                 240 


Val Val Ser Ser Lys Pro Val Gly Gly Gln Val Ile Val Ala Ile Pro 
                245                 250                 255     


Lys Leu Gln Thr Gln Gln Thr Tyr Ser Ile Glu Leu Gln Pro Gly Lys 
            260                 265                 270         


Arg Ile Val Glu Leu Phe Val Asn Ile Ser Lys Asn Ile Thr Val Glu 
        275                 280                 285             


Thr Trp Trp Pro His Gly His Gly Asn Gln Thr Gly Tyr Asn Met Thr 
    290                 295                 300                 


Val Leu Phe Glu Leu Asp Gly Gly Leu Asn Ile Glu Lys Ser Ala Lys 
305                 310                 315                 320 


Val Tyr Phe Arg Thr Val Glu Leu Ile Glu Glu Pro Ile Lys Gly Ser 
                325                 330                 335     


Pro Gly Leu Ser Phe Tyr Phe Lys Ile Asn Gly Phe Pro Ile Phe Leu 
            340                 345                 350         


Lys Gly Ser Asn Trp Ile Pro Ala Asp Ser Phe Gln Asp Arg Val Thr 
        355                 360                 365             


Ser Glu Leu Leu Arg Leu Leu Leu Gln Ser Val Val Asp Ala Asn Met 
    370                 375                 380                 


Asn Thr Leu Arg Val Trp Gly Gly Gly Ile Tyr Glu Gln Asp Glu Phe 
385                 390                 395                 400 


Tyr Glu Leu Cys Asp Glu Leu Gly Ile Met Val Trp Gln Asp Phe Met 
                405                 410                 415     


Phe Ala Cys Ala Leu Tyr Pro Thr Asp Gln Gly Phe Leu Asp Ser Val 
            420                 425                 430         


Thr Ala Glu Val Ala Tyr Gln Ile Lys Arg Leu Lys Ser His Pro Ser 
        435                 440                 445             


Ile Ile Ile Trp Ser Gly Asn Asn Glu Asn Glu Glu Ala Leu Met Met 
    450                 455                 460                 


Asn Trp Tyr His Ile Ser Phe Thr Asp Arg Pro Ile Tyr Ile Lys Asp 
465                 470                 475                 480 


Tyr Val Thr Leu Tyr Val Lys Asn Ile Arg Glu Leu Val Leu Ala Gly 
                485                 490                 495     


Asp Lys Ser Arg Pro Phe Ile Thr Ser Ser Pro Thr Asn Gly Ala Glu 
            500                 505                 510         


Thr Val Ala Glu Ala Trp Val Ser Gln Asn Pro Asn Ser Asn Tyr Phe 
        515                 520                 525             


Gly Asp Val His Phe Tyr Asp Tyr Ile Ser Asp Cys Trp Asn Trp Lys 
    530                 535                 540                 


Val Phe Pro Lys Ala Arg Phe Ala Ser Glu Tyr Gly Tyr Gln Ser Trp 
545                 550                 555                 560 


Pro Ser Phe Ser Thr Leu Glu Lys Val Ser Ser Thr Glu Asp Trp Ser 
                565                 570                 575     


Phe Asn Ser Lys Phe Ser Leu His Arg Gln His His Glu Gly Gly Asn 
            580                 585                 590         


Lys Gln Met Leu Tyr Gln Ala Gly Leu His Phe Lys Leu Pro Gln Ser 
        595                 600                 605             


Thr Asp Pro Leu Arg Thr Phe Lys Asp Thr Ile Tyr Leu Thr Gln Val 
    610                 615                 620                 


Met Gln Ala Gln Cys Val Lys Thr Glu Thr Glu Phe Tyr Arg Arg Ser 
625                 630                 635                 640 


Arg Ser Glu Ile Val Asp Gln Gln Gly His Thr Met Gly Ala Leu Tyr 
                645                 650                 655     


Trp Gln Leu Asn Asp Ile Trp Gln Ala Pro Ser Trp Ala Ser Leu Glu 
            660                 665                 670         


Tyr Gly Gly Lys Trp Lys Met Leu His Tyr Phe Ala Gln Asn Phe Phe 
        675                 680                 685             


Ala Pro Leu Leu Pro Val Gly Phe Glu Asn Glu Asn Thr Phe Tyr Ile 
    690                 695                 700                 


Tyr Gly Val Ser Asp Leu His Ser Asp Tyr Ser Met Thr Leu Ser Val 
705                 710                 715                 720 


Arg Val His Thr Trp Ser Ser Leu Glu Pro Val Cys Ser Arg Val Thr 
                725                 730                 735     


Glu Arg Phe Val Met Lys Gly Gly Glu Ala Val Cys Leu Tyr Glu Glu 
            740                 745                 750         


Pro Val Ser Glu Leu Leu Arg Arg Cys Gly Asn Cys Thr Arg Glu Ser 
        755                 760                 765             


Cys Val Val Ser Phe Tyr Leu Ser Ala Asp His Glu Leu Leu Ser Pro 
    770                 775                 780                 


Thr Asn Tyr His Phe Leu Ser Ser Pro Lys Glu Ala Val Gly Leu Cys 
785                 790                 795                 800 


Lys Ala Gln Ile Thr Ala Ile Ile Ser Gln Gln Gly Asp Ile Phe Val 
                805                 810                 815     


Phe Asp Leu Glu Thr Ser Ala Val Ala Pro Phe Val Trp Leu Asp Val 
            820                 825                 830         


Gly Ser Ile Pro Gly Arg Phe Ser Asp Asn Gly Phe Leu Met Thr Glu 
        835                 840                 845             


Lys Thr Arg Thr Ile Leu Phe Tyr Pro Trp Glu Pro Thr Ser Lys Asn 
    850                 855                 860                 


Glu Leu Glu Gln Ser Phe His Val Thr Ser Leu Thr Asp Ile Tyr 
865                 870                 875                 


<210>  8293
<211>  365
<212>  PRT
<213>  Homo Sapiens

<400>  8293

Met Arg Leu His Leu Leu Leu Leu Leu Ala Leu Cys Gly Ala Gly Thr 
1               5                   10                  15      


Thr Ala Ala Glu Leu Ser Tyr Ser Leu Arg Gly Asn Trp Ser Ile Cys 
            20                  25                  30          


Asn Gly Asn Gly Ser Leu Glu Leu Pro Gly Ala Val Pro Gly Cys Val 
        35                  40                  45              


His Ser Ala Leu Phe Gln Gln Gly Leu Ile Gln Asp Ser Tyr Tyr Arg 
    50                  55                  60                  


Phe Asn Asp Leu Asn Tyr Arg Trp Val Ser Leu Asp Asn Trp Thr Tyr 
65                  70                  75                  80  


Ser Lys Glu Phe Lys Ile Pro Phe Glu Ile Ser Lys Trp Gln Lys Val 
                85                  90                  95      


Asn Leu Ile Leu Glu Gly Val Asp Thr Val Ser Lys Ile Leu Phe Asn 
            100                 105                 110         


Glu Val Thr Ile Gly Glu Thr Asp Asn Met Phe Asn Arg Tyr Ser Phe 
        115                 120                 125             


Asp Ile Thr Asn Val Val Arg Asp Val Asn Ser Ile Glu Leu Arg Phe 
    130                 135                 140                 


Gln Ser Ala Val Leu Tyr Ala Ala Gln Gln Ser Lys Ala His Thr Arg 
145                 150                 155                 160 


Tyr Gln Val Pro Pro Asp Cys Pro Pro Leu Val Gln Lys Gly Glu Cys 
                165                 170                 175     


His Val Asn Phe Val Arg Lys Glu Gln Cys Ser Phe Ser Trp Asp Trp 
            180                 185                 190         


Gly Pro Ser Phe Pro Thr Gln Gly Ile Trp Lys Asp Val Arg Ile Glu 
        195                 200                 205             


Ala Tyr Asn Ile Cys His Leu Asn Tyr Phe Thr Phe Ser Pro Ile Tyr 
    210                 215                 220                 


Asp Lys Ser Ala Gln Glu Trp Asn Leu Glu Ile Glu Ser Thr Phe Asp 
225                 230                 235                 240 


Val Val Ser Ser Lys Pro Val Gly Gly Gln Val Ile Val Ala Ile Pro 
                245                 250                 255     


Lys Leu Gln Thr Gln Gln Thr Tyr Ser Ile Glu Leu Gln Pro Gly Lys 
            260                 265                 270         


Arg Ile Val Glu Leu Phe Val Asn Ile Ser Lys Asn Ile Thr Val Glu 
        275                 280                 285             


Thr Trp Trp Pro His Gly His Gly Asn Gln Thr Gly Tyr Asn Met Thr 
    290                 295                 300                 


Val Leu Phe Glu Leu Asp Gly Gly Leu Asn Ile Glu Lys Ser Ala Lys 
305                 310                 315                 320 


Ser Trp Arg Leu Glu Ser Lys Ile Lys Val Ser Ala Glu Leu Cys Ser 
                325                 330                 335     


Phe Arg Arg Leu Trp Glu Arg Ile Leu Pro Cys Pro Phe Gln Phe Leu 
            340                 345                 350         


Ile Ile Ala Gly Asn Pro Trp Leu Val Asp Ala Ser Leu 
        355                 360                 365 


<210>  8294
<211>  925
<212>  PRT
<213>  Homo Sapiens

<400>  8294

Met Arg Leu His Leu Leu Leu Leu Leu Ala Leu Cys Gly Ala Gly Thr 
1               5                   10                  15      


Thr Ala Ala Glu Leu Ser Tyr Ser Leu Arg Gly Asn Trp Ser Ile Cys 
            20                  25                  30          


Asn Gly Asn Gly Ser Leu Glu Leu Pro Gly Ala Val Pro Gly Cys Val 
        35                  40                  45              


His Ser Ala Leu Phe Gln Gln Gly Leu Ile Gln Asp Ser Tyr Tyr Arg 
    50                  55                  60                  


Phe Asn Asp Leu Asn Tyr Arg Trp Val Ser Leu Asp Asn Trp Thr Tyr 
65                  70                  75                  80  


Ser Lys Glu Phe Lys Ile Pro Phe Glu Ile Ser Lys Trp Gln Lys Val 
                85                  90                  95      


Asn Leu Ile Leu Glu Gly Val Asp Thr Val Ser Lys Ile Leu Phe Asn 
            100                 105                 110         


Glu Val Thr Ile Gly Glu Thr Asp Asn Met Phe Asn Arg Tyr Ser Phe 
        115                 120                 125             


Asp Ile Thr Asn Val Val Arg Asp Val Asn Ser Ile Glu Leu Arg Phe 
    130                 135                 140                 


Gln Ser Ala Val Leu Tyr Ala Ala Gln Gln Ser Lys Ala His Thr Arg 
145                 150                 155                 160 


Tyr Gln Val Pro Pro Asp Cys Pro Pro Leu Val Gln Lys Gly Glu Cys 
                165                 170                 175     


His Val Asn Phe Val Arg Lys Glu Gln Cys Ser Phe Ser Trp Asp Trp 
            180                 185                 190         


Gly Pro Ser Phe Pro Thr Gln Gly Ile Trp Lys Asp Val Arg Ile Glu 
        195                 200                 205             


Ala Tyr Asn Ile Cys His Leu Asn Tyr Phe Thr Phe Ser Pro Ile Tyr 
    210                 215                 220                 


Asp Lys Ser Ala Gln Glu Trp Asn Leu Glu Ile Glu Ser Thr Phe Asp 
225                 230                 235                 240 


Val Val Ser Ser Lys Pro Val Gly Gly Gln Val Ile Val Ala Ile Pro 
                245                 250                 255     


Lys Leu Gln Thr Gln Gln Thr Tyr Ser Ile Glu Leu Gln Pro Gly Lys 
            260                 265                 270         


Arg Ile Val Glu Leu Phe Val Asn Ile Ser Lys Asn Ile Thr Val Glu 
        275                 280                 285             


Thr Trp Trp Pro His Gly His Gly Asn Gln Thr Gly Tyr Asn Met Thr 
    290                 295                 300                 


Val Leu Phe Glu Leu Asp Gly Gly Leu Asn Ile Glu Lys Ser Ala Lys 
305                 310                 315                 320 


Val Tyr Phe Arg Thr Val Glu Leu Ile Glu Glu Pro Ile Lys Gly Ser 
                325                 330                 335     


Pro Gly Leu Ser Phe Tyr Phe Lys Ile Asn Gly Phe Pro Ile Phe Leu 
            340                 345                 350         


Lys Gly Ser Asn Trp Ile Pro Ala Asp Ser Phe Gln Asp Arg Val Thr 
        355                 360                 365             


Ser Glu Leu Phe His Lys Lys Met Lys Phe Phe Ser Arg His Ser His 
    370                 375                 380                 


Gly Ile Ile Gly Ser Ile Phe Phe Leu Phe Lys Cys Ser Ser Pro Leu 
385                 390                 395                 400 


Pro Ala Gly Ala Gly Leu Ala Val Val Leu Gln Pro Asn Trp Ala Asn 
                405                 410                 415     


Trp Leu Arg Leu Leu Leu Gln Ser Val Val Asp Ala Asn Met Asn Thr 
            420                 425                 430         


Leu Arg Val Trp Gly Gly Gly Ile Tyr Glu Gln Asp Glu Phe Tyr Glu 
        435                 440                 445             


Leu Cys Asp Glu Leu Gly Ile Met Val Trp Gln Asp Phe Met Phe Ala 
    450                 455                 460                 


Cys Ala Leu Tyr Pro Thr Asp Gln Gly Phe Leu Asp Ser Val Thr Ala 
465                 470                 475                 480 


Glu Val Ala Tyr Gln Ile Lys Arg Leu Lys Ser His Pro Ser Ile Ile 
                485                 490                 495     


Ile Trp Ser Gly Asn Asn Glu Asn Glu Glu Ala Leu Met Met Asn Trp 
            500                 505                 510         


Tyr His Ile Ser Phe Thr Asp Arg Pro Ile Tyr Ile Lys Asp Tyr Val 
        515                 520                 525             


Thr Leu Tyr Val Lys Asn Ile Arg Glu Leu Val Leu Ala Gly Asp Lys 
    530                 535                 540                 


Ser Arg Pro Phe Ile Thr Ser Ser Pro Thr Asn Gly Ala Glu Thr Val 
545                 550                 555                 560 


Ala Glu Ala Trp Val Ser Gln Asn Pro Asn Ser Asn Tyr Phe Gly Asp 
                565                 570                 575     


Val His Phe Tyr Asp Tyr Ile Ser Asp Cys Trp Asn Trp Lys Val Phe 
            580                 585                 590         


Pro Lys Ala Arg Phe Ala Ser Glu Tyr Gly Tyr Gln Ser Trp Pro Ser 
        595                 600                 605             


Phe Ser Thr Leu Glu Lys Val Ser Ser Thr Glu Asp Trp Ser Phe Asn 
    610                 615                 620                 


Ser Lys Phe Ser Leu His Arg Gln His His Glu Gly Gly Asn Lys Gln 
625                 630                 635                 640 


Met Leu Tyr Gln Ala Gly Leu His Phe Lys Leu Pro Gln Ser Thr Asp 
                645                 650                 655     


Pro Leu Arg Thr Phe Lys Asp Thr Ile Tyr Leu Thr Gln Val Met Gln 
            660                 665                 670         


Ala Gln Cys Val Lys Thr Glu Thr Glu Phe Tyr Arg Arg Ser Arg Ser 
        675                 680                 685             


Glu Ile Val Asp Gln Gln Gly His Thr Met Gly Ala Leu Tyr Trp Gln 
    690                 695                 700                 


Leu Asn Asp Ile Trp Gln Ala Pro Ser Trp Ala Ser Leu Glu Tyr Gly 
705                 710                 715                 720 


Gly Lys Trp Lys Met Leu His Tyr Phe Ala Gln Asn Phe Phe Ala Pro 
                725                 730                 735     


Leu Leu Pro Val Gly Phe Glu Asn Glu Asn Thr Phe Tyr Ile Tyr Gly 
            740                 745                 750         


Val Ser Asp Leu His Ser Asp Tyr Ser Met Thr Leu Ser Val Arg Val 
        755                 760                 765             


His Thr Trp Ser Ser Leu Glu Pro Val Cys Ser Arg Val Thr Glu Arg 
    770                 775                 780                 


Phe Val Met Lys Gly Gly Glu Ala Val Cys Leu Tyr Glu Glu Pro Val 
785                 790                 795                 800 


Ser Glu Leu Leu Arg Arg Cys Gly Asn Cys Thr Arg Glu Ser Cys Val 
                805                 810                 815     


Val Ser Phe Tyr Leu Ser Ala Asp His Glu Leu Leu Ser Pro Thr Asn 
            820                 825                 830         


Tyr His Phe Leu Ser Ser Pro Lys Glu Ala Val Gly Leu Cys Lys Ala 
        835                 840                 845             


Gln Ile Thr Ala Ile Ile Ser Gln Gln Gly Asp Ile Phe Val Phe Asp 
    850                 855                 860                 


Leu Glu Thr Ser Ala Val Ala Pro Phe Val Trp Leu Asp Val Gly Ser 
865                 870                 875                 880 


Ile Pro Gly Arg Phe Ser Asp Asn Gly Phe Leu Met Thr Glu Lys Thr 
                885                 890                 895     


Arg Thr Ile Leu Phe Tyr Pro Trp Glu Pro Thr Ser Lys Asn Glu Leu 
            900                 905                 910         


Glu Gln Ser Phe His Val Thr Ser Leu Thr Asp Ile Tyr 
        915                 920                 925 


<210>  8295
<211>  62
<212>  PRT
<213>  Homo Sapiens

<400>  8295

Met Arg Leu His Leu Leu Leu Leu Leu Ala Leu Cys Gly Ala Gly Thr 
1               5                   10                  15      


Thr Ala Ala Glu Leu Ser Tyr Ser Leu Arg Gly Asn Trp Ser Ile Cys 
            20                  25                  30          


Asn Gly Asn Gly Ser Leu Glu Leu Pro Gly Ala Val Pro Gly Cys Val 
        35                  40                  45              


His Ser Ala Leu Phe Gln Gln Gly Leu Ile Gln Lys Glu Gln 
    50                  55                  60          


<210>  8296
<211>  68
<212>  PRT
<213>  Homo Sapiens

<400>  8296

Met Arg Leu His Leu Leu Leu Leu Leu Ala Leu Cys Gly Ala Gly Thr 
1               5                   10                  15      


Thr Ala Ala Glu Leu Ser Tyr Ser Leu Arg Gly Asn Trp Ser Ile Cys 
            20                  25                  30          


Asn Gly Asn Gly Ser Leu Glu Leu Pro Gly Ala Val Pro Gly Cys Val 
        35                  40                  45              


His Ser Ala Leu Phe Gln Gln Gly Leu Ile Gln Ser Leu Thr Leu Ser 
    50                  55                  60                  


Pro Arg Leu Glu 
65              


<210>  8297
<211>  199
<212>  PRT
<213>  Homo Sapiens

<400>  8297

Met Ser Lys Ala Glu Trp Asp Thr Asp Gln Trp Lys Thr Glu Asn Tyr 
1               5                   10                  15      


Ile Asn Glu Ser Thr Glu Ala Gln Ser Lys Gln Lys Glu Gln Lys Ser 
            20                  25                  30          


Ser Glu Asp Ser Tyr Tyr Arg Phe Asn Asp Leu Asn Tyr Arg Trp Val 
        35                  40                  45              


Ser Leu Asp Asn Trp Thr Tyr Ser Lys Glu Phe Lys Ile Pro Phe Glu 
    50                  55                  60                  


Ile Ser Lys Trp Gln Lys Val Asn Leu Ile Leu Glu Gly Val Asp Thr 
65                  70                  75                  80  


Val Ser Lys Ile Leu Phe Asn Glu Val Thr Ile Gly Glu Thr Asp Asn 
                85                  90                  95      


Met Phe Asn Arg Tyr Ser Phe Asp Ile Thr Asn Val Val Arg Asp Val 
            100                 105                 110         


Asn Ser Ile Glu Leu Arg Phe Gln Ser Ala Val Leu Tyr Ala Ala Gln 
        115                 120                 125             


Gln Ser Lys Ala His Thr Arg Tyr Gln Val Pro Pro Asp Cys Pro Pro 
    130                 135                 140                 


Leu Val Gln Lys Gly Glu Cys His Val Asn Phe Val Arg Lys Glu Gln 
145                 150                 155                 160 


Cys Ser Phe Ser Trp Asp Trp Gly Pro Ser Phe Pro Thr Gln Gly Ile 
                165                 170                 175     


Trp Lys Asp Val Arg Ile Glu Ala Tyr Asn Ile Cys His Leu Asn Tyr 
            180                 185                 190         


Phe Thr Phe Ser Pro Ile Tyr 
        195                 


<210>  8298
<211>  215
<212>  PRT
<213>  Homo Sapiens

<400>  8298

Ser Lys Ile Leu Phe Asn Glu Val Thr Ile Gly Glu Thr Asp Asn Met 
1               5                   10                  15      


Phe Asn Arg Tyr Ser Phe Asp Ile Thr Asn Val Val Arg Asp Val Asn 
            20                  25                  30          


Ser Ile Glu Leu Arg Phe Gln Ser Ala Val Leu Tyr Ala Ala Gln Gln 
        35                  40                  45              


Ser Lys Ala His Thr Arg Tyr Gln Val Pro Pro Asp Cys Pro Pro Leu 
    50                  55                  60                  


Val Gln Lys Gly Glu Cys His Val Asn Phe Val Arg Lys Glu Gln Cys 
65                  70                  75                  80  


Ser Phe Ser Trp Asp Trp Gly Pro Ser Phe Pro Thr Gln Gly Ile Trp 
                85                  90                  95      


Lys Asp Val Arg Ile Glu Ala Tyr Asn Ile Cys His Leu Asn Tyr Phe 
            100                 105                 110         


Thr Phe Ser Pro Ile Tyr Asp Lys Ser Ala Gln Glu Trp Asn Leu Glu 
        115                 120                 125             


Ile Glu Ser Thr Phe Asp Val Val Ser Ser Lys Pro Val Gly Gly Gln 
    130                 135                 140                 


Val Ile Val Ala Ile Pro Lys Leu Gln Thr Gln Gln Thr Tyr Ser Ile 
145                 150                 155                 160 


Glu Leu Gln Pro Gly Lys Arg Ile Val Glu Leu Phe Val Asn Ile Ser 
                165                 170                 175     


Lys Asn Ile Thr Val Glu Thr Trp Trp Pro His Gly His Gly Asn Gln 
            180                 185                 190         


Thr Gly Tyr Asn Met Thr Val Leu Phe Glu Leu Asp Gly Gly Leu Asn 
        195                 200                 205             


Ile Glu Lys Ser Ala Lys Leu 
    210                 215 


<210>  8299
<211>  230
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8299

Xaa Asp Cys Pro Pro Leu Val Gln Lys Gly Glu Cys His Val Asn Phe 
1               5                   10                  15      


Val Arg Lys Glu Gln Cys Ser Phe Ser Trp Asp Trp Gly Pro Ser Phe 
            20                  25                  30          


Pro Thr Gln Gly Ile Trp Lys Asp Val Arg Ile Glu Ala Tyr Asn Ile 
        35                  40                  45              


Cys His Leu Asn Tyr Phe Thr Phe Ser Pro Ile Tyr Asp Lys Ser Ala 
    50                  55                  60                  


Gln Glu Trp Asn Leu Glu Ile Glu Ser Thr Phe Asp Val Val Ser Ser 
65                  70                  75                  80  


Lys Pro Val Gly Gly Gln Val Ile Val Ala Ile Pro Lys Leu Gln Thr 
                85                  90                  95      


Gln Gln Thr Tyr Ser Ile Glu Leu Gln Pro Gly Lys Arg Ile Val Glu 
            100                 105                 110         


Leu Phe Val Asn Ile Ser Lys Asn Ile Thr Val Glu Thr Trp Trp Pro 
        115                 120                 125             


His Gly His Gly Asn Gln Thr Gly Tyr Asn Met Thr Val Leu Phe Glu 
    130                 135                 140                 


Leu Asp Gly Gly Leu Asn Ile Glu Lys Ser Ala Lys Val Tyr Phe Arg 
145                 150                 155                 160 


Thr Val Glu Leu Ile Glu Glu Pro Ile Lys Gly Ser Pro Gly Leu Ser 
                165                 170                 175     


Phe Tyr Phe Lys Ile Asn Gly Phe Pro Ile Phe Leu Lys Gly Ser Asn 
            180                 185                 190         


Trp Ile Pro Ala Asp Ser Phe Gln Asp Arg Val Thr Ser Glu Phe Trp 
        195                 200                 205             


Gly Trp Val Gly Cys Gly Pro Ser Ala Gln Leu Gly Gln Leu Val Ser 
    210                 215                 220                 


Leu Pro Trp Cys Leu Cys 
225                 230 


<210>  8300
<211>  263
<212>  PRT
<213>  Homo Sapiens

<400>  8300

Met Ala Asp Asp Asn Gly Glu Pro Ser Asp Asp Leu Val Pro Ala Ile 
1               5                   10                  15      


Leu Asp Thr Ala His Gln Tyr Ser Ile Gln Val Ala Phe His Ile Gln 
            20                  25                  30          


Pro Tyr Lys Gly Arg Asp Asp Ile Thr Val His Asp Asn Ile Lys Tyr 
        35                  40                  45              


Ile Ile Asp Thr Tyr Gly Ser His Gly Ala Phe Tyr Arg Tyr Lys Asn 
    50                  55                  60                  


Ser Met Gly Lys Ser Leu Pro Leu Phe Tyr Ile Tyr Asp Ser Tyr Leu 
65                  70                  75                  80  


Thr Ser Pro Glu Ala Trp Ala His Leu Leu Thr Pro Asn Gly Pro His 
                85                  90                  95      


Ser Ile Arg Asn Thr Pro Tyr Asp Gly Val Phe Ile Ala Leu Leu Val 
            100                 105                 110         


Glu Glu Gly His Thr His Asp Ile Leu Ala Ala Gly Phe Asp Gly Met 
        115                 120                 125             


Tyr Thr Tyr Phe Ala Ser Asn Gly Phe Ser Phe Gly Ser Ser His Gln 
    130                 135                 140                 


Asn Trp Lys Ala Val Lys Asn Phe Cys Asp Ala Asn Asn Leu Met Phe 
145                 150                 155                 160 


Ile Pro Ser Val Gly Pro Gly Tyr Ile Asp Thr Ser Ile Arg Pro Trp 
                165                 170                 175     


Asn Asn His Asn Thr Arg Asn Arg Val Asn Gly Lys Tyr Tyr Glu Thr 
            180                 185                 190         


Ala Leu Gln Ala Ala Leu Thr Val Arg Pro Glu Ile Val Ser Ile Thr 
        195                 200                 205             


Ser Phe Asn Glu Trp His Glu Gly Thr Gln Ile Glu Lys Ala Ile Pro 
    210                 215                 220                 


Lys Lys Thr Pro Thr Arg Leu Tyr Leu Asp Tyr Leu Pro His Gln Pro 
225                 230                 235                 240 


Ser Leu Tyr Leu Glu Leu Thr Arg Arg Trp Ala Glu His Phe Ile Lys 
                245                 250                 255     


Glu Lys Glu Gln Trp Leu Met 
            260             


<210>  8301
<211>  250
<212>  PRT
<213>  Homo Sapiens

<400>  8301

Met Ala Arg Arg Arg Arg Arg Ala Cys Ile Ala Leu Phe Leu Val Leu 
1               5                   10                  15      


Leu Phe Ala Phe Gly Thr Leu Met Gly Leu Arg Thr Leu Lys Ala Pro 
            20                  25                  30          


Asp Gly Leu Pro Ala Leu Gly Pro Gly Leu Glu Leu Ala Pro Phe Glu 
        35                  40                  45              


Arg Arg Pro Glu Gly Ala Pro Ala Pro Ala Ala Arg Ala Pro Ala Ala 
    50                  55                  60                  


Pro Ala Ala Pro Pro Pro Pro Pro Pro Pro Pro Arg Thr Ala Asp Pro 
65                  70                  75                  80  


Gly Gly Ser Pro Gly Pro Ala Pro Ala Glu Ala Glu Pro Ala Pro Val 
                85                  90                  95      


Gln Ser Leu Arg Val Tyr Ser Asp Leu His Ala Phe Tyr Tyr Ser Trp 
            100                 105                 110         


Tyr Gly Ser Pro Arg Arg Glu Gly His Tyr Ile His Trp Asp His Val 
        115                 120                 125             


Met Val Pro His Trp Asp Pro Lys Ile Ser Ala Ser Tyr Pro Arg Gly 
    130                 135                 140                 


Arg His Ser Pro Pro Asp Asp Leu Gly Ser Ser Phe Tyr Pro Glu Leu 
145                 150                 155                 160 


Gly Pro Tyr Ser Ser Arg Asp Pro Glu Val Leu Arg Glu His Met Thr 
                165                 170                 175     


Gln Leu Lys Glu Ala Ala Ile Gly Val Leu Val Leu Ser Trp Tyr Pro 
            180                 185                 190         


Pro Gly Met Ala Asp Asp Asn Gly Glu Pro Ser Asp Asp Leu Val Pro 
        195                 200                 205             


Ala Ile Leu Asp Thr Ala His Gln Tyr Ser Ile Gln Val Ala Phe His 
    210                 215                 220                 


Ile Gln Pro Tyr Lys Gly Arg Asp Asp Ile Thr Val His Asp Asn Ile 
225                 230                 235                 240 


Lys Tyr Ile Ile Asp Thr Thr Gly Lys Leu 
                245                 250 


<210>  8302
<211>  457
<212>  PRT
<213>  Homo Sapiens

<400>  8302

Met Ala Arg Arg Arg Arg Arg Ala Cys Ile Ala Leu Phe Leu Val Leu 
1               5                   10                  15      


Leu Phe Ala Phe Gly Thr Leu Met Gly Leu Arg Thr Leu Lys Ala Pro 
            20                  25                  30          


Asp Gly Leu Pro Ala Leu Gly Pro Gly Leu Glu Leu Ala Pro Phe Glu 
        35                  40                  45              


Arg Arg Pro Glu Gly Ala Pro Ala Pro Ala Ala Arg Ala Pro Ala Ala 
    50                  55                  60                  


Pro Ala Ala Pro Pro Pro Pro Pro Pro Pro Pro Arg Thr Ala Asp Pro 
65                  70                  75                  80  


Gly Gly Ser Pro Gly Pro Ala Pro Ala Glu Ala Glu Pro Ala Pro Val 
                85                  90                  95      


Gln Ser Leu Arg Val Tyr Ser Asp Leu His Ala Phe Tyr Tyr Ser Trp 
            100                 105                 110         


Tyr Gly Ser Pro Arg Arg Glu Gly His Tyr Ile His Trp Asp His Val 
        115                 120                 125             


Met Val Pro His Trp Asp Pro Lys Ile Ser Ala Ser Tyr Pro Arg Gly 
    130                 135                 140                 


Arg His Ser Pro Pro Asp Asp Leu Gly Ser Ser Phe Tyr Pro Glu Leu 
145                 150                 155                 160 


Gly Pro Tyr Ser Ser Arg Asp Pro Glu Val Leu Arg Glu His Met Thr 
                165                 170                 175     


Gln Leu Lys Glu Ala Ala Ile Gly Val Leu Val Leu Ser Trp Tyr Pro 
            180                 185                 190         


Pro Gly Met Ala Asp Asp Asn Gly Glu Pro Ser Asp Asp Leu Val Pro 
        195                 200                 205             


Ala Ile Leu Asp Thr Ala His Gln Tyr Ser Ile Gln Val Ala Phe His 
    210                 215                 220                 


Ile Gln Pro Tyr Lys Gly Arg Asp Asp Ile Thr Val His Asp Asn Ile 
225                 230                 235                 240 


Lys Tyr Ile Ile Asp Thr Tyr Gly Ser His Gly Ala Phe Tyr Arg Tyr 
                245                 250                 255     


Lys Asn Ser Met Gly Lys Ser Leu Pro Leu Phe Tyr Ile Tyr Asp Ser 
            260                 265                 270         


Tyr Leu Thr Ser Pro Glu Ala Trp Ala His Leu Leu Thr Pro Asn Gly 
        275                 280                 285             


Pro His Ser Ile Arg Asn Thr Pro Tyr Asp Gly Val Phe Ile Ala Leu 
    290                 295                 300                 


Leu Val Glu Glu Gly His Thr His Asp Ile Leu Ala Ala Gly Phe Asp 
305                 310                 315                 320 


Gly Met Tyr Thr Tyr Phe Ala Ser Asn Gly Phe Ser Phe Gly Ser Ser 
                325                 330                 335     


His Gln Asn Trp Lys Ala Val Lys Asn Phe Cys Asp Ala Asn Asn Leu 
            340                 345                 350         


Met Phe Ile Pro Ser Val Gly Pro Gly Tyr Ile Asp Thr Ser Ile Arg 
        355                 360                 365             


Pro Trp Asn Asn His Asn Thr Arg Asn Arg Val Asn Gly Lys Tyr Tyr 
    370                 375                 380                 


Glu Thr Ala Leu Gln Ala Ala Leu Thr Val Arg Pro Glu Ile Val Ser 
385                 390                 395                 400 


Ile Thr Ser Phe Asn Glu Trp His Glu Gly Thr Gln Ile Glu Lys Ala 
                405                 410                 415     


Ile Pro Lys Lys Thr Pro Thr Arg Leu Tyr Leu Asp Tyr Leu Pro His 
            420                 425                 430         


Gln Pro Ser Leu Tyr Leu Glu Leu Thr Arg Arg Trp Ala Glu His Phe 
        435                 440                 445             


Ile Lys Glu Lys Glu Gln Trp Leu Met 
    450                 455         


<210>  8303
<211>  235
<212>  PRT
<213>  Homo Sapiens

<400>  8303

Met Ile Thr Gly Ser Pro Gln Met Thr Trp Cys Pro Pro Phe Trp Thr 
1               5                   10                  15      


Pro Pro Ile Ser Thr Ala Ser Arg Tyr Gly Ser His Gly Ala Phe Tyr 
            20                  25                  30          


Arg Tyr Lys Asn Ser Met Gly Lys Ser Leu Pro Leu Phe Tyr Ile Tyr 
        35                  40                  45              


Asp Ser Tyr Leu Thr Ser Pro Glu Ala Trp Ala His Leu Leu Thr Pro 
    50                  55                  60                  


Asn Gly Pro His Ser Ile Arg Asn Thr Pro Tyr Asp Gly Val Phe Ile 
65                  70                  75                  80  


Ala Leu Leu Val Glu Glu Gly His Thr His Asp Ile Leu Ala Ala Gly 
                85                  90                  95      


Phe Asp Gly Met Tyr Thr Tyr Phe Ala Ser Asn Gly Phe Ser Phe Gly 
            100                 105                 110         


Ser Ser His Gln Asn Trp Lys Ala Val Lys Asn Phe Cys Asp Ala Asn 
        115                 120                 125             


Asn Leu Met Phe Ile Pro Ser Val Gly Pro Gly Tyr Ile Asp Thr Ser 
    130                 135                 140                 


Ile Arg Pro Trp Asn Asn His Asn Thr Arg Asn Arg Val Asn Gly Lys 
145                 150                 155                 160 


Tyr Tyr Glu Thr Ala Leu Gln Ala Ala Leu Thr Val Arg Pro Glu Ile 
                165                 170                 175     


Val Ser Ile Thr Ser Phe Asn Glu Trp His Glu Gly Thr Gln Ile Glu 
            180                 185                 190         


Lys Ala Ile Pro Lys Lys Thr Pro Thr Arg Leu Tyr Leu Asp Tyr Leu 
        195                 200                 205             


Pro His Gln Pro Ser Leu Tyr Leu Glu Leu Thr Arg Arg Trp Ala Glu 
    210                 215                 220                 


His Phe Ile Lys Glu Lys Glu Gln Trp Leu Met 
225                 230                 235 


<210>  8304
<211>  130
<212>  PRT
<213>  Homo Sapiens

<400>  8304

Val Tyr Ser Asp Leu His Ala Phe Tyr Tyr Ser Trp Tyr Gly Ser Pro 
1               5                   10                  15      


Arg Arg Glu Gly His Tyr Ile His Trp Asp His Val Met Val Pro His 
            20                  25                  30          


Trp Asp Pro Lys Ile Ser Ala Ser Tyr Pro Arg Gly Arg His Ser Pro 
        35                  40                  45              


Pro Asp Asp Leu Gly Ser Ser Phe Tyr Pro Glu Leu Gly Pro Tyr Ser 
    50                  55                  60                  


Ser Arg Asp Pro Glu Val Leu Arg Glu His Met Thr Gln Leu Lys Glu 
65                  70                  75                  80  


Ala Ala Ile Gly Val Leu Val Leu Ser Trp Tyr Pro Pro Gly Met Ala 
                85                  90                  95      


Asp Asp Asn Gly Glu Pro Ser Asp Asp Leu Val Pro Ala Ile Leu Asp 
            100                 105                 110         


Thr Ala His Gln Tyr Ser Ile Gln Val Trp Leu Pro Trp Cys Ile Leu 
        115                 120                 125             


Pro Leu 
    130 


<210>  8305
<211>  185
<212>  PRT
<213>  Homo Sapiens

<400>  8305

Met Arg Arg Met Arg Arg Met Trp Ala Thr Gln Gly Leu Ala Val Ala 
1               5                   10                  15      


Leu Ala Leu Ser Val Leu Pro Gly Ser Arg Ala Leu Arg Pro Gly Asp 
            20                  25                  30          


Cys Glu Val Cys Ile Ser Tyr Leu Gly Arg Phe Tyr Gln Asp Leu Lys 
        35                  40                  45              


Asp Arg Asp Val Thr Phe Ser Pro Ala Thr Ile Glu Asn Glu Leu Ile 
    50                  55                  60                  


Lys Phe Cys Arg Glu Ala Arg Gly Lys Glu Asn Arg Leu Cys Tyr Tyr 
65                  70                  75                  80  


Ile Gly Ala Thr Asp Asp Ala Ala Thr Lys Ile Ile Asn Glu Val Ser 
                85                  90                  95      


Lys Pro Leu Ala His His Ile Pro Val Glu Lys Ile Cys Glu Lys Leu 
            100                 105                 110         


Lys Lys Lys Asp Ser Gln Ile Cys Glu Leu Lys Tyr Asp Lys Gln Ile 
        115                 120                 125             


Asp Leu Ser Thr Val Asp Leu Lys Lys Leu Arg Val Lys Glu Leu Lys 
    130                 135                 140                 


Lys Ile Leu Asp Asp Trp Gly Glu Thr Cys Lys Gly Cys Ala Glu Lys 
145                 150                 155                 160 


Ser Asp Tyr Ile Arg Lys Ile Asn Glu Leu Met Pro Lys Tyr Ala Pro 
                165                 170                 175     


Lys Ala Ala Ser Ala Arg Thr Asp Leu 
            180                 185 


<210>  8306
<211>  71
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8306

Xaa Ala Thr Gln Gly Leu Ala Val Ala Leu Ala Leu Ser Val Leu Pro 
1               5                   10                  15      


Gly Ser Arg Ala Leu Arg Pro Gly Asp Cys Glu Val Cys Ile Ser Tyr 
            20                  25                  30          


Leu Gly Arg Phe Tyr Gln Asp Leu Lys Asp Arg Asp Val Thr Phe Ser 
        35                  40                  45              


Pro Ala Thr Ile Glu Asn Glu Leu Ile Lys Phe Cys Arg Glu Ala Arg 
    50                  55                  60                  


Gly Lys Glu Asn Arg Leu Val 
65                  70      


<210>  8307
<211>  397
<212>  PRT
<213>  Homo Sapiens

<400>  8307

Met Phe Phe Gly Gly Glu Gly Ser Leu Thr Tyr Thr Leu Gly Ile Arg 
1               5                   10                  15      


Gly Asn Glu Pro Val Tyr Thr Ser Thr Gln Glu Asp Cys Ile Asn Ser 
            20                  25                  30          


Cys Cys Ser Thr Lys Asn Ile Ser Gly Asp Lys Ala Cys Asn Leu Met 
        35                  40                  45              


Ile Phe Asp Thr Arg Lys Thr Ala Arg Gln Pro Asn Cys Tyr Leu Phe 
    50                  55                  60                  


Phe Cys Pro Asn Glu Glu Ala Cys Pro Leu Lys Pro Ala Lys Gly Leu 
65                  70                  75                  80  


Met Ser Tyr Arg Ile Ile Thr Asp Phe Pro Ser Leu Thr Arg Asn Leu 
                85                  90                  95      


Pro Ser Gln Glu Leu Pro Gln Glu Asp Ser Leu Leu His Gly Gln Phe 
            100                 105                 110         


Ser Gln Ala Val Thr Pro Leu Ala His His His Thr Asp Tyr Ser Lys 
        115                 120                 125             


Pro Thr Asp Ile Ser Trp Arg Asp Thr Leu Ser Gln Lys Phe Gly Ser 
    130                 135                 140                 


Ser Asp His Leu Glu Lys Leu Phe Lys Met Asp Glu Ala Ser Ala Gln 
145                 150                 155                 160 


Leu Leu Ala Tyr Lys Glu Lys Gly His Ser Gln Ser Ser Gln Phe Ser 
                165                 170                 175     


Ser Asp Gln Glu Ile Ala His Leu Leu Pro Glu Asn Val Ser Ala Leu 
            180                 185                 190         


Pro Ala Thr Val Ala Val Ala Ser Pro His Thr Thr Ser Ala Thr Pro 
        195                 200                 205             


Lys Pro Ala Thr Leu Leu Pro Thr Asn Ala Ser Val Thr Pro Ser Gly 
    210                 215                 220                 


Thr Ser Gln Pro Gln Leu Ala Thr Thr Ala Pro Pro Val Thr Thr Val 
225                 230                 235                 240 


Thr Ser Gln Pro Pro Thr Thr Leu Ile Ser Thr Val Phe Thr Arg Ala 
                245                 250                 255     


Ala Ala Thr Leu Gln Ala Met Ala Thr Thr Ala Val Leu Thr Thr Thr 
            260                 265                 270         


Phe Gln Ala Pro Thr Asp Ser Lys Gly Ser Leu Glu Thr Ile Pro Phe 
        275                 280                 285             


Thr Glu Ile Ser Asn Leu Thr Leu Asn Thr Gly Asn Val Tyr Asn Pro 
    290                 295                 300                 


Thr Ala Leu Ser Met Ser Asn Val Glu Ser Ser Thr Met Asn Lys Thr 
305                 310                 315                 320 


Ala Ser Trp Glu Gly Arg Glu Ala Ser Pro Gly Ser Ser Ser Gln Gly 
                325                 330                 335     


Ser Val Pro Glu Asn Gln Tyr Gly Leu Pro Phe Glu Lys Trp Leu Leu 
            340                 345                 350         


Ile Gly Ser Leu Leu Phe Gly Val Leu Phe Leu Val Ile Gly Leu Val 
        355                 360                 365             


Leu Leu Gly Arg Ile Leu Ser Glu Ser Leu Arg Arg Lys Arg Tyr Ser 
    370                 375                 380                 


Arg Leu Asp Tyr Leu Ile Asn Gly Ile Tyr Val Asp Ile 
385                 390                 395         


<210>  8308
<211>  57
<212>  PRT
<213>  Homo Sapiens

<400>  8308

Met Phe Phe Gly Gly Glu Gly Ser Leu Thr Tyr Thr Leu Val Ile Ile 
1               5                   10                  15      


Cys Phe Leu Thr Leu Arg Leu Ser Ala Ser Gln Asn Cys Leu Lys Lys 
            20                  25                  30          


Ser Leu Glu Asp Val Val Ile Asp Ile Gln Ser Ser Leu Ser Lys Gly 
        35                  40                  45              


Ile Arg Gly Asn Glu Pro Val Tyr Thr 
    50                  55          


<210>  8309
<211>  431
<212>  PRT
<213>  Homo Sapiens

<400>  8309

Met Phe Phe Gly Gly Glu Gly Ser Leu Thr Tyr Thr Leu Val Ile Ile 
1               5                   10                  15      


Cys Phe Leu Thr Leu Arg Leu Ser Ala Ser Gln Asn Cys Leu Lys Lys 
            20                  25                  30          


Ser Leu Glu Asp Val Val Ile Asp Ile Gln Ser Ser Leu Ser Lys Gly 
        35                  40                  45              


Ile Arg Gly Asn Glu Pro Val Tyr Thr Ser Thr Gln Glu Asp Cys Ile 
    50                  55                  60                  


Asn Ser Cys Cys Ser Thr Lys Asn Ile Ser Gly Asp Lys Ala Cys Asn 
65                  70                  75                  80  


Leu Met Ile Phe Asp Thr Arg Lys Thr Ala Arg Gln Pro Asn Cys Tyr 
                85                  90                  95      


Leu Phe Phe Cys Pro Asn Glu Glu Ala Cys Pro Leu Lys Pro Ala Lys 
            100                 105                 110         


Gly Leu Met Ser Tyr Arg Ile Ile Thr Asp Phe Pro Ser Leu Thr Arg 
        115                 120                 125             


Asn Leu Pro Ser Gln Glu Leu Pro Gln Glu Asp Ser Leu Leu His Gly 
    130                 135                 140                 


Gln Phe Ser Gln Ala Val Thr Pro Leu Ala His His His Thr Asp Tyr 
145                 150                 155                 160 


Ser Lys Pro Thr Asp Ile Ser Trp Arg Asp Thr Leu Ser Gln Lys Phe 
                165                 170                 175     


Gly Ser Ser Asp His Leu Glu Lys Leu Phe Lys Met Asp Glu Ala Ser 
            180                 185                 190         


Ala Gln Leu Leu Ala Tyr Lys Glu Lys Gly His Ser Gln Ser Ser Gln 
        195                 200                 205             


Phe Ser Ser Asp Gln Glu Ile Ala His Leu Leu Pro Glu Asn Val Ser 
    210                 215                 220                 


Ala Leu Pro Ala Thr Val Ala Val Ala Ser Pro His Thr Thr Ser Ala 
225                 230                 235                 240 


Thr Pro Lys Pro Ala Thr Leu Leu Pro Thr Asn Ala Ser Val Thr Pro 
                245                 250                 255     


Ser Gly Thr Ser Gln Pro Gln Leu Ala Thr Thr Ala Pro Pro Val Thr 
            260                 265                 270         


Thr Val Thr Ser Gln Pro Pro Thr Thr Leu Ile Ser Thr Val Phe Thr 
        275                 280                 285             


Arg Ala Ala Ala Thr Leu Gln Ala Met Ala Thr Thr Ala Val Leu Thr 
    290                 295                 300                 


Thr Thr Phe Gln Ala Pro Thr Asp Ser Lys Gly Ser Leu Glu Thr Ile 
305                 310                 315                 320 


Pro Phe Thr Glu Ile Ser Asn Leu Thr Leu Asn Thr Gly Asn Val Tyr 
                325                 330                 335     


Asn Pro Thr Ala Leu Ser Met Ser Asn Val Glu Ser Ser Thr Met Asn 
            340                 345                 350         


Lys Thr Ala Ser Trp Glu Gly Arg Glu Ala Ser Pro Gly Ser Ser Ser 
        355                 360                 365             


Gln Gly Ser Val Pro Glu Asn Gln Tyr Gly Leu Pro Phe Glu Lys Trp 
    370                 375                 380                 


Leu Leu Ile Gly Ser Leu Leu Phe Gly Val Leu Phe Leu Val Ile Gly 
385                 390                 395                 400 


Leu Val Leu Leu Gly Arg Ile Leu Ser Glu Ser Leu Arg Arg Lys Arg 
                405                 410                 415     


Tyr Ser Arg Leu Asp Tyr Leu Ile Asn Gly Ile Tyr Val Asp Ile 
            420                 425                 430     


<210>  8310
<211>  350
<212>  PRT
<213>  Homo Sapiens

<400>  8310

Met Ile Phe Asp Thr Arg Lys Thr Ala Arg Gln Pro Asn Cys Tyr Leu 
1               5                   10                  15      


Phe Phe Cys Pro Asn Glu Glu Ala Cys Pro Leu Lys Pro Ala Lys Gly 
            20                  25                  30          


Leu Met Ser Tyr Arg Ile Ile Thr Asp Phe Pro Ser Leu Thr Arg Asn 
        35                  40                  45              


Leu Pro Ser Gln Glu Leu Pro Gln Glu Asp Ser Leu Leu His Gly Gln 
    50                  55                  60                  


Phe Ser Gln Ala Val Thr Pro Leu Ala His His His Thr Asp Tyr Ser 
65                  70                  75                  80  


Lys Pro Thr Asp Ile Ser Trp Arg Asp Thr Leu Ser Gln Lys Phe Gly 
                85                  90                  95      


Ser Ser Asp His Leu Glu Lys Leu Phe Lys Met Asp Glu Ala Ser Ala 
            100                 105                 110         


Gln Leu Leu Ala Tyr Lys Glu Lys Gly His Ser Gln Ser Ser Gln Phe 
        115                 120                 125             


Ser Ser Asp Gln Glu Ile Ala His Leu Leu Pro Glu Asn Val Ser Ala 
    130                 135                 140                 


Leu Pro Ala Thr Val Ala Val Ala Ser Pro His Thr Thr Ser Ala Thr 
145                 150                 155                 160 


Pro Lys Pro Ala Thr Leu Leu Pro Thr Asn Ala Ser Val Thr Pro Ser 
                165                 170                 175     


Gly Thr Ser Gln Pro Gln Leu Ala Thr Thr Ala Pro Pro Val Thr Thr 
            180                 185                 190         


Val Thr Ser Gln Pro Pro Thr Thr Leu Ile Ser Thr Val Phe Thr Arg 
        195                 200                 205             


Ala Ala Ala Thr Leu Gln Ala Met Ala Thr Thr Ala Val Leu Thr Thr 
    210                 215                 220                 


Thr Phe Gln Ala Pro Thr Asp Ser Lys Gly Ser Leu Glu Thr Ile Pro 
225                 230                 235                 240 


Phe Thr Glu Ile Ser Asn Leu Thr Leu Asn Thr Gly Asn Val Tyr Asn 
                245                 250                 255     


Pro Thr Ala Leu Ser Met Ser Asn Val Glu Ser Ser Thr Met Asn Lys 
            260                 265                 270         


Thr Ala Ser Trp Glu Gly Arg Glu Ala Ser Pro Gly Ser Ser Ser Gln 
        275                 280                 285             


Gly Ser Val Pro Glu Asn Gln Tyr Gly Leu Pro Phe Glu Lys Trp Leu 
    290                 295                 300                 


Leu Ile Gly Ser Leu Leu Phe Gly Val Leu Phe Leu Val Ile Gly Leu 
305                 310                 315                 320 


Val Leu Leu Gly Arg Ile Leu Ser Glu Ser Leu Arg Arg Lys Arg Tyr 
                325                 330                 335     


Ser Arg Leu Asp Tyr Leu Ile Asn Gly Ile Tyr Val Asp Ile 
            340                 345                 350 


<210>  8311
<211>  832
<212>  PRT
<213>  Homo Sapiens

<400>  8311

Met Glu Leu Thr Gly Leu Glu Val Ala Leu Val Leu Ile Leu Gln Lys 
1               5                   10                  15      


Val Glu Asn Gly Asp Leu Ser Asn Lys Ile Leu Lys Ile Thr Asp Phe 
            20                  25                  30          


Gly Leu Ala Arg Glu Trp His Arg Thr Thr Lys Met Ser Ala Ala Gly 
        35                  40                  45              


Thr Tyr Ala Trp Met Ala Pro Glu Val Ile Arg Ala Ser Met Phe Ser 
    50                  55                  60                  


Lys Gly Ser Asp Val Trp Ser Tyr Gly Val Leu Leu Trp Glu Leu Leu 
65                  70                  75                  80  


Thr Gly Glu Val Pro Phe Arg Gly Ile Asp Gly Leu Ala Val Ala Tyr 
                85                  90                  95      


Gly Val Ala Met Asn Lys Leu Ala Leu Pro Ile Pro Ser Thr Cys Pro 
            100                 105                 110         


Glu Pro Phe Ala Lys Leu Met Glu Asp Cys Trp Asn Pro Asp Pro His 
        115                 120                 125             


Ser Arg Pro Ser Phe Thr Asn Ile Leu Asp Gln Leu Thr Thr Ile Glu 
    130                 135                 140                 


Glu Ser Gly Phe Phe Glu Met Pro Lys Asp Ser Phe His Cys Leu Gln 
145                 150                 155                 160 


Asp Asn Trp Lys His Glu Ile Gln Glu Met Phe Asp Gln Leu Arg Ala 
                165                 170                 175     


Lys Glu Lys Glu Leu Arg Thr Trp Glu Glu Glu Leu Thr Arg Ala Ala 
            180                 185                 190         


Leu Gln Gln Lys Asn Gln Glu Glu Leu Leu Arg Arg Arg Glu Gln Glu 
        195                 200                 205             


Leu Ala Glu Arg Glu Ile Asp Ile Leu Glu Arg Glu Leu Asn Ile Ile 
    210                 215                 220                 


Ile His Gln Leu Cys Gln Glu Lys Pro Arg Val Lys Lys Arg Lys Gly 
225                 230                 235                 240 


Lys Phe Arg Lys Ser Arg Leu Lys Leu Lys Asp Gly Asn Arg Ile Ser 
                245                 250                 255     


Leu Pro Ser Asp Phe Gln His Lys Phe Thr Val Gln Ala Ser Pro Thr 
            260                 265                 270         


Met Asp Lys Arg Lys Ser Leu Ile Asn Ser Arg Ser Ser Pro Pro Ala 
        275                 280                 285             


Ser Pro Thr Ile Ile Pro Arg Leu Arg Ala Ile Gln Leu Thr Pro Gly 
    290                 295                 300                 


Glu Ser Ser Lys Thr Trp Gly Arg Ser Ser Val Val Pro Lys Glu Glu 
305                 310                 315                 320 


Gly Glu Glu Glu Glu Lys Arg Ala Pro Lys Lys Lys Gly Arg Thr Trp 
                325                 330                 335     


Gly Pro Gly Thr Leu Gly Gln Lys Glu Leu Ala Ser Gly Asp Glu Gly 
            340                 345                 350         


Leu Lys Ser Leu Val Asp Gly Tyr Lys Gln Trp Ser Ser Ser Ala Pro 
        355                 360                 365             


Asn Leu Val Lys Gly Pro Arg Ser Ser Pro Ala Leu Pro Gly Phe Thr 
    370                 375                 380                 


Ser Leu Met Glu Met Ala Leu Leu Ala Ala Ser Trp Val Val Pro Ile 
385                 390                 395                 400 


Asp Ile Glu Glu Asp Glu Asp Ser Glu Gly Pro Gly Ser Gly Glu Ser 
                405                 410                 415     


Arg Leu Gln His Ser Pro Ser Gln Ser Tyr Leu Cys Ile Pro Phe Pro 
            420                 425                 430         


Arg Gly Glu Asp Gly Asp Gly Pro Ser Ser Asp Gly Ile His Glu Glu 
        435                 440                 445             


Pro Thr Pro Val Asn Ser Ala Thr Ser Thr Pro Gln Leu Thr Pro Thr 
    450                 455                 460                 


Asn Ser Leu Lys Arg Gly Gly Ala His His Arg Arg Cys Glu Val Ala 
465                 470                 475                 480 


Leu Leu Gly Cys Gly Ala Val Leu Ala Ala Thr Gly Leu Gly Phe Asp 
                485                 490                 495     


Leu Leu Glu Ala Gly Lys Cys Gln Leu Leu Pro Leu Glu Glu Pro Glu 
            500                 505                 510         


Pro Pro Ala Arg Glu Glu Lys Lys Arg Arg Glu Gly Leu Phe Gln Arg 
        515                 520                 525             


Ser Ser Arg Pro Arg Arg Ser Thr Ser Pro Pro Ser Arg Lys Leu Phe 
    530                 535                 540                 


Lys Lys Glu Glu Pro Met Leu Leu Leu Gly Asp Pro Ser Ala Ser Leu 
545                 550                 555                 560 


Thr Leu Leu Ser Leu Ser Ser Ile Ser Glu Cys Asn Ser Thr Arg Ser 
                565                 570                 575     


Leu Leu Arg Ser Asp Ser Asp Glu Ile Val Val Tyr Glu Met Pro Val 
            580                 585                 590         


Ser Pro Val Glu Ala Pro Pro Leu Ser Pro Cys Thr His Asn Pro Leu 
        595                 600                 605             


Val Asn Val Arg Val Glu Arg Phe Lys Arg Asp Pro Asn Gln Ser Leu 
    610                 615                 620                 


Thr Pro Thr His Val Thr Leu Thr Thr Pro Ser Gln Pro Ser Ser His 
625                 630                 635                 640 


Arg Arg Thr Pro Ser Asp Gly Ala Leu Lys Pro Glu Thr Leu Leu Ala 
                645                 650                 655     


Ser Arg Ser Pro Ser Ser Asn Gly Leu Ser Pro Ser Pro Gly Ala Gly 
            660                 665                 670         


Met Leu Lys Thr Pro Ser Pro Ser Arg Asp Pro Gly Glu Phe Pro Arg 
        675                 680                 685             


Leu Pro Asp Pro Asn Val Val Phe Pro Pro Thr Pro Arg Arg Trp Asn 
    690                 695                 700                 


Thr Gln Gln Asp Ser Thr Leu Glu Arg Pro Lys Thr Leu Glu Phe Leu 
705                 710                 715                 720 


Pro Arg Pro Arg Pro Ser Ala Asn Arg Gln Arg Leu Asp Pro Trp Trp 
                725                 730                 735     


Phe Val Ser Pro Ser His Ala Arg Ser Thr Ser Pro Ala Asn Ser Ser 
            740                 745                 750         


Ser Thr Glu Thr Pro Ser Asn Leu Asp Ser Cys Phe Ala Ser Ser Ser 
        755                 760                 765             


Ser Thr Val Glu Glu Arg Pro Gly Leu Pro Ala Leu Leu Pro Phe Gln 
    770                 775                 780                 


Ala Gly Pro Leu Pro Pro Thr Glu Arg Thr Leu Leu Asp Leu Asp Ala 
785                 790                 795                 800 


Glu Gly Gln Ser Gln Asp Ser Thr Val Pro Leu Cys Arg Ala Glu Leu 
                805                 810                 815     


Asn Thr His Arg Pro Ala Pro Tyr Glu Ile Gln Gln Glu Phe Trp Ser 
            820                 825                 830         


<210>  8312
<211>  880
<212>  PRT
<213>  Homo Sapiens

<400>  8312

Met Glu Leu Thr Gly Leu Glu Val Ala Leu Val Leu Ile Leu Gln Lys 
1               5                   10                  15      


Val Glu Asn Gly Asp Leu Ser Asn Lys Ile Leu Lys Ile Thr Asp Phe 
            20                  25                  30          


Gly Leu Ala Arg Glu Trp His Arg Thr Thr Lys Met Ser Ala Ala Gly 
        35                  40                  45              


Thr Tyr Ala Trp Met Ala Pro Glu Val Ile Arg Ala Ser Met Phe Ser 
    50                  55                  60                  


Lys Gly Ser Asp Val Trp Ser Tyr Gly Val Leu Leu Trp Glu Leu Leu 
65                  70                  75                  80  


Thr Gly Glu Val Pro Phe Arg Gly Ile Asp Gly Leu Ala Val Ala Tyr 
                85                  90                  95      


Gly Val Ala Met Asn Lys Leu Ala Leu Pro Ile Pro Ser Thr Cys Pro 
            100                 105                 110         


Glu Pro Phe Ala Lys Leu Met Glu Asp Cys Trp Asn Pro Asp Pro His 
        115                 120                 125             


Ser Arg Pro Ser Phe Thr Asn Ile Leu Asp Gln Leu Thr Thr Ile Glu 
    130                 135                 140                 


Glu Ser Gly Phe Phe Glu Met Pro Lys Asp Ser Phe His Cys Leu Gln 
145                 150                 155                 160 


Asp Asn Trp Lys His Glu Ile Gln Glu Met Phe Asp Gln Leu Arg Ala 
                165                 170                 175     


Lys Glu Lys Glu Leu Arg Thr Trp Glu Glu Glu Leu Thr Arg Ala Ala 
            180                 185                 190         


Leu Gln Gln Lys Asn Gln Glu Glu Leu Leu Arg Arg Arg Glu Gln Glu 
        195                 200                 205             


Leu Ala Glu Arg Glu Ile Asp Ile Leu Glu Arg Glu Leu Asn Ile Ile 
    210                 215                 220                 


Ile His Gln Leu Cys Gln Glu Lys Pro Arg Val Lys Lys Arg Lys Gly 
225                 230                 235                 240 


Lys Phe Arg Lys Ser Arg Leu Lys Leu Lys Asp Gly Asn Arg Ile Ser 
                245                 250                 255     


Leu Pro Ser Asp Phe Gln His Lys Phe Thr Val Gln Ala Ser Pro Thr 
            260                 265                 270         


Met Asp Lys Arg Lys Ser Leu Ile Asn Ser Arg Ser Ser Pro Pro Ala 
        275                 280                 285             


Ser Pro Thr Ile Ile Pro Arg Leu Arg Ala Ile Gln Cys Glu Thr Val 
    290                 295                 300                 


Ser Gln Ile Ser Trp Gly Gln Asn Thr Gln Gly His Leu Ser Pro Ala 
305                 310                 315                 320 


Leu Ser Ser His Arg Leu Val Gln Ala Cys Ser Ile His Asn Phe Cys 
                325                 330                 335     


His Leu Ser Ser Thr Met Cys Ile Tyr Met His Ile Leu Thr Pro Gly 
            340                 345                 350         


Glu Ser Ser Lys Thr Trp Gly Arg Ser Ser Val Val Pro Lys Glu Glu 
        355                 360                 365             


Gly Glu Glu Glu Glu Lys Arg Ala Pro Lys Lys Lys Gly Arg Thr Trp 
    370                 375                 380                 


Gly Pro Gly Thr Leu Gly Gln Lys Glu Leu Ala Ser Gly Asp Glu Gly 
385                 390                 395                 400 


Leu Lys Ser Leu Val Asp Gly Tyr Lys Gln Trp Ser Ser Ser Ala Pro 
                405                 410                 415     


Asn Leu Val Lys Gly Pro Arg Ser Ser Pro Ala Leu Pro Gly Phe Thr 
            420                 425                 430         


Ser Leu Met Glu Met Ala Leu Leu Ala Ala Ser Trp Val Val Pro Ile 
        435                 440                 445             


Asp Ile Glu Glu Asp Glu Asp Ser Glu Gly Pro Gly Ser Gly Glu Ser 
    450                 455                 460                 


Arg Leu Gln His Ser Pro Ser Gln Ser Tyr Leu Cys Ile Pro Phe Pro 
465                 470                 475                 480 


Arg Gly Glu Asp Gly Asp Gly Pro Ser Ser Asp Gly Ile His Glu Glu 
                485                 490                 495     


Pro Thr Pro Val Asn Ser Ala Thr Ser Thr Pro Gln Leu Thr Pro Thr 
            500                 505                 510         


Asn Ser Leu Lys Arg Gly Gly Ala His His Arg Arg Cys Glu Val Ala 
        515                 520                 525             


Leu Leu Gly Cys Gly Ala Val Leu Ala Ala Thr Gly Leu Gly Phe Asp 
    530                 535                 540                 


Leu Leu Glu Ala Gly Lys Cys Gln Leu Leu Pro Leu Glu Glu Pro Glu 
545                 550                 555                 560 


Pro Pro Ala Arg Glu Glu Lys Lys Arg Arg Glu Gly Leu Phe Gln Arg 
                565                 570                 575     


Ser Ser Arg Pro Arg Arg Ser Thr Ser Pro Pro Ser Arg Lys Leu Phe 
            580                 585                 590         


Lys Lys Glu Glu Pro Met Leu Leu Leu Gly Asp Pro Ser Ala Ser Leu 
        595                 600                 605             


Thr Leu Leu Ser Leu Ser Ser Ile Ser Glu Cys Asn Ser Thr Arg Ser 
    610                 615                 620                 


Leu Leu Arg Ser Asp Ser Asp Glu Ile Val Val Tyr Glu Met Pro Val 
625                 630                 635                 640 


Ser Pro Val Glu Ala Pro Pro Leu Ser Pro Cys Thr His Asn Pro Leu 
                645                 650                 655     


Val Asn Val Arg Val Glu Arg Phe Lys Arg Asp Pro Asn Gln Ser Leu 
            660                 665                 670         


Thr Pro Thr His Val Thr Leu Thr Thr Pro Ser Gln Pro Ser Ser His 
        675                 680                 685             


Arg Arg Thr Pro Ser Asp Gly Ala Leu Lys Pro Glu Thr Leu Leu Ala 
    690                 695                 700                 


Ser Arg Ser Pro Ser Ser Asn Gly Leu Ser Pro Ser Pro Gly Ala Gly 
705                 710                 715                 720 


Met Leu Lys Thr Pro Ser Pro Ser Arg Asp Pro Gly Glu Phe Pro Arg 
                725                 730                 735     


Leu Pro Asp Pro Asn Val Val Phe Pro Pro Thr Pro Arg Arg Trp Asn 
            740                 745                 750         


Thr Gln Gln Asp Ser Thr Leu Glu Arg Pro Lys Thr Leu Glu Phe Leu 
        755                 760                 765             


Pro Arg Pro Arg Pro Ser Ala Asn Arg Gln Arg Leu Asp Pro Trp Trp 
    770                 775                 780                 


Phe Val Ser Pro Ser His Ala Arg Ser Thr Ser Pro Ala Asn Ser Ser 
785                 790                 795                 800 


Ser Thr Glu Thr Pro Ser Asn Leu Asp Ser Cys Phe Ala Ser Ser Ser 
                805                 810                 815     


Ser Thr Val Glu Glu Arg Pro Gly Leu Pro Ala Leu Leu Pro Phe Gln 
            820                 825                 830         


Ala Gly Pro Leu Pro Pro Thr Glu Arg Thr Leu Leu Asp Leu Asp Ala 
        835                 840                 845             


Glu Gly Gln Ser Gln Asp Ser Thr Val Pro Leu Cys Arg Ala Glu Leu 
    850                 855                 860                 


Asn Thr His Arg Pro Ala Pro Tyr Glu Ile Gln Gln Glu Phe Trp Ser 
865                 870                 875                 880 


<210>  8313
<211>  1081
<212>  PRT
<213>  Homo Sapiens

<400>  8313

Met Glu Pro Ser Arg Ala Leu Leu Gly Cys Leu Ala Ser Ala Ala Ala 
1               5                   10                  15      


Ala Ala Pro Pro Gly Glu Asp Gly Ala Gly Ala Gly Ala Glu Glu Glu 
            20                  25                  30          


Glu Glu Glu Glu Glu Glu Ala Ala Ala Ala Val Gly Pro Gly Glu Leu 
        35                  40                  45              


Gly Cys Asp Ala Pro Leu Pro Tyr Trp Thr Ala Val Phe Glu Tyr Glu 
    50                  55                  60                  


Ala Ala Gly Glu Asp Glu Leu Thr Leu Arg Leu Gly Asp Val Val Glu 
65                  70                  75                  80  


Val Leu Ser Lys Asp Ser Gln Val Ser Gly Asp Glu Gly Trp Trp Thr 
                85                  90                  95      


Gly Gln Leu Asn Gln Arg Val Gly Ile Phe Pro Ser Asn Tyr Val Thr 
            100                 105                 110         


Pro Arg Ser Ala Phe Ser Ser Arg Cys Gln Pro Gly Gly Glu Asp Pro 
        115                 120                 125             


Ser Cys Tyr Pro Pro Ile Gln Leu Leu Glu Ile Asp Phe Ala Glu Leu 
    130                 135                 140                 


Thr Leu Glu Glu Ile Ile Gly Ile Gly Gly Phe Gly Lys Val Tyr Arg 
145                 150                 155                 160 


Ala Phe Trp Ile Gly Asp Glu Val Ala Val Lys Ala Ala Arg His Asp 
                165                 170                 175     


Pro Asp Glu Asp Ile Ser Gln Thr Ile Glu Asn Val Arg Gln Glu Ala 
            180                 185                 190         


Lys Leu Phe Ala Met Leu Lys His Pro Asn Ile Ile Ala Leu Arg Gly 
        195                 200                 205             


Val Cys Leu Lys Glu Pro Asn Leu Cys Leu Val Met Glu Phe Ala Arg 
    210                 215                 220                 


Gly Gly Pro Leu Asn Arg Val Leu Ser Gly Lys Arg Ile Pro Pro Asp 
225                 230                 235                 240 


Ile Leu Val Asn Trp Ala Val Gln Ile Ala Arg Gly Met Asn Tyr Leu 
                245                 250                 255     


His Asp Glu Ala Ile Val Pro Ile Ile His Arg Asp Leu Lys Ser Ser 
            260                 265                 270         


Asn Ile Leu Ile Leu Gln Lys Val Glu Asn Gly Asp Leu Ser Asn Lys 
        275                 280                 285             


Ile Leu Lys Ile Thr Asp Phe Gly Leu Ala Arg Glu Trp His Arg Thr 
    290                 295                 300                 


Thr Lys Met Ser Ala Ala Gly Thr Tyr Ala Trp Met Ala Pro Glu Val 
305                 310                 315                 320 


Ile Arg Ala Ser Met Phe Ser Lys Gly Ser Asp Val Trp Ser Tyr Gly 
                325                 330                 335     


Val Leu Leu Trp Glu Leu Leu Thr Gly Glu Val Pro Phe Arg Gly Ile 
            340                 345                 350         


Asp Gly Leu Ala Val Ala Tyr Gly Val Ala Met Asn Lys Leu Ala Leu 
        355                 360                 365             


Pro Ile Pro Ser Thr Cys Pro Glu Pro Phe Ala Lys Leu Met Glu Asp 
    370                 375                 380                 


Cys Trp Asn Pro Asp Pro His Ser Arg Pro Ser Phe Thr Asn Ile Leu 
385                 390                 395                 400 


Asp Gln Leu Thr Thr Ile Glu Glu Ser Gly Phe Phe Glu Met Pro Lys 
                405                 410                 415     


Asp Ser Phe His Cys Leu Gln Asp Asn Trp Lys His Glu Ile Gln Glu 
            420                 425                 430         


Met Phe Asp Gln Leu Arg Ala Lys Glu Lys Glu Leu Arg Thr Trp Glu 
        435                 440                 445             


Glu Glu Leu Thr Arg Ala Ala Leu Gln Gln Lys Asn Gln Glu Glu Leu 
    450                 455                 460                 


Leu Arg Arg Arg Glu Gln Glu Leu Ala Glu Arg Glu Ile Asp Ile Leu 
465                 470                 475                 480 


Glu Arg Glu Leu Asn Ile Ile Ile His Gln Leu Cys Gln Glu Lys Pro 
                485                 490                 495     


Arg Val Lys Lys Arg Lys Gly Lys Phe Arg Lys Ser Arg Leu Lys Leu 
            500                 505                 510         


Lys Asp Gly Asn Arg Ile Ser Leu Pro Ser Asp Phe Gln His Lys Phe 
        515                 520                 525             


Thr Val Gln Ala Ser Pro Thr Met Asp Lys Arg Lys Ser Leu Ile Asn 
    530                 535                 540                 


Ser Arg Ser Ser Pro Pro Ala Ser Pro Thr Ile Ile Pro Arg Leu Arg 
545                 550                 555                 560 


Ala Ile Gln Leu Thr Pro Gly Glu Ser Ser Lys Thr Trp Gly Arg Ser 
                565                 570                 575     


Ser Val Val Pro Lys Glu Glu Gly Glu Glu Glu Glu Lys Arg Ala Pro 
            580                 585                 590         


Lys Lys Lys Gly Arg Thr Trp Gly Pro Gly Thr Leu Gly Gln Lys Glu 
        595                 600                 605             


Leu Ala Ser Gly Asp Glu Gly Leu Lys Ser Leu Val Asp Gly Tyr Lys 
    610                 615                 620                 


Gln Trp Ser Ser Ser Ala Pro Asn Leu Val Lys Gly Pro Arg Ser Ser 
625                 630                 635                 640 


Pro Ala Leu Pro Gly Phe Thr Ser Leu Met Glu Met Glu Asp Glu Asp 
                645                 650                 655     


Ser Glu Gly Pro Gly Ser Gly Glu Ser Arg Leu Gln His Ser Pro Ser 
            660                 665                 670         


Gln Ser Tyr Leu Cys Ile Pro Phe Pro Arg Gly Glu Asp Gly Asp Gly 
        675                 680                 685             


Pro Ser Ser Asp Gly Ile His Glu Glu Pro Thr Pro Val Asn Ser Ala 
    690                 695                 700                 


Thr Ser Thr Pro Gln Leu Thr Pro Thr Asn Ser Leu Lys Arg Gly Gly 
705                 710                 715                 720 


Ala His His Arg Arg Cys Glu Val Ala Leu Leu Gly Cys Gly Ala Val 
                725                 730                 735     


Leu Ala Ala Thr Gly Leu Gly Phe Asp Leu Leu Glu Ala Gly Lys Cys 
            740                 745                 750         


Gln Leu Leu Pro Leu Glu Glu Pro Glu Pro Pro Ala Arg Glu Glu Lys 
        755                 760                 765             


Lys Arg Arg Glu Gly Leu Phe Gln Arg Ser Ser Arg Pro Arg Arg Ser 
    770                 775                 780                 


Thr Ser Pro Pro Ser Arg Lys Leu Phe Lys Lys Glu Glu Pro Met Leu 
785                 790                 795                 800 


Leu Leu Gly Asp Pro Ser Ala Ser Leu Thr Leu Leu Ser Leu Ser Ser 
                805                 810                 815     


Ile Ser Glu Cys Asn Ser Thr Arg Ser Leu Leu Arg Ser Asp Ser Asp 
            820                 825                 830         


Glu Ile Val Val Tyr Glu Met Pro Val Ser Pro Val Glu Ala Pro Pro 
        835                 840                 845             


Leu Ser Pro Cys Thr His Asn Pro Leu Val Asn Val Arg Val Glu Arg 
    850                 855                 860                 


Phe Lys Arg Asp Pro Asn Gln Ser Leu Thr Pro Thr His Val Thr Leu 
865                 870                 875                 880 


Thr Thr Pro Ser Gln Pro Ser Ser His Arg Arg Thr Pro Ser Asp Gly 
                885                 890                 895     


Ala Leu Lys Pro Glu Thr Leu Leu Ala Ser Arg Ser Pro Ser Ser Asn 
            900                 905                 910         


Gly Leu Ser Pro Ser Pro Gly Ala Gly Met Leu Lys Thr Pro Ser Pro 
        915                 920                 925             


Ser Arg Asp Pro Gly Glu Phe Pro Arg Leu Pro Asp Pro Asn Val Val 
    930                 935                 940                 


Phe Pro Pro Thr Pro Arg Arg Trp Asn Thr Gln Gln Asp Ser Thr Leu 
945                 950                 955                 960 


Glu Arg Pro Lys Thr Leu Glu Phe Leu Pro Arg Pro Arg Pro Ser Ala 
                965                 970                 975     


Asn Arg Gln Arg Leu Asp Pro Trp Trp Phe Val Ser Pro Ser His Ala 
            980                 985                 990         


Arg Ser Thr Ser Pro Ala Asn Ser  Ser Ser Thr Glu Thr  Pro Ser Asn 
        995                 1000                 1005             


Leu Asp  Ser Cys Phe Ala Ser  Ser Ser Ser Thr Val  Glu Glu Arg 
    1010                 1015                 1020             


Pro Gly  Leu Pro Ala Leu Leu  Pro Phe Gln Ala Gly  Pro Leu Pro 
    1025                 1030                 1035             


Pro Thr  Glu Arg Thr Leu Leu  Asp Leu Asp Ala Glu  Gly Gln Ser 
    1040                 1045                 1050             


Gln Asp  Ser Thr Val Pro Leu  Cys Arg Ala Glu Leu  Asn Thr His 
    1055                 1060                 1065             


Arg Pro  Ala Pro Tyr Glu Ile  Gln Gln Glu Phe Trp  Ser 
    1070                 1075                 1080     


<210>  8314
<211>  1118
<212>  PRT
<213>  Homo Sapiens

<400>  8314

Met Glu Pro Ser Arg Ala Leu Leu Gly Cys Leu Ala Ser Ala Ala Ala 
1               5                   10                  15      


Ala Ala Pro Pro Gly Glu Asp Gly Ala Gly Ala Gly Ala Glu Glu Glu 
            20                  25                  30          


Glu Glu Glu Glu Glu Glu Ala Ala Ala Ala Val Gly Pro Gly Glu Leu 
        35                  40                  45              


Gly Cys Asp Ala Pro Leu Pro Tyr Trp Thr Ala Val Phe Glu Tyr Glu 
    50                  55                  60                  


Ala Ala Gly Glu Asp Glu Leu Thr Leu Arg Leu Gly Asp Val Val Glu 
65                  70                  75                  80  


Val Leu Ser Lys Asp Ser Gln Val Ser Gly Asp Glu Gly Trp Trp Thr 
                85                  90                  95      


Gly Gln Leu Asn Gln Arg Val Gly Ile Phe Pro Ser Asn Tyr Val Thr 
            100                 105                 110         


Pro Arg Ser Ala Phe Ser Ser Arg Cys Gln Pro Gly Gly Glu Asp Pro 
        115                 120                 125             


Ser Cys Tyr Pro Pro Ile Gln Leu Leu Glu Ile Asp Phe Ala Glu Leu 
    130                 135                 140                 


Thr Leu Glu Glu Ile Ile Gly Ile Gly Gly Phe Gly Lys Val Tyr Arg 
145                 150                 155                 160 


Ala Phe Trp Ile Gly Asp Glu Val Ala Val Lys Ala Ala Arg His Asp 
                165                 170                 175     


Pro Asp Glu Asp Ile Ser Gln Thr Ile Glu Asn Val Arg Gln Glu Ala 
            180                 185                 190         


Lys Leu Phe Ala Met Leu Lys His Pro Asn Ile Ile Ala Leu Arg Gly 
        195                 200                 205             


Val Cys Leu Lys Glu Pro Asn Leu Cys Leu Val Met Glu Phe Ala Arg 
    210                 215                 220                 


Gly Gly Pro Leu Asn Arg Val Leu Ser Gly Lys Arg Ile Pro Pro Asp 
225                 230                 235                 240 


Ile Leu Val Asn Trp Ala Val Gln Ile Ala Arg Gly Met Asn Tyr Leu 
                245                 250                 255     


His Asp Glu Ala Ile Val Pro Ile Ile His Arg Asp Leu Lys Ser Ser 
            260                 265                 270         


Asn Ile Leu Ile Leu Gln Lys Val Glu Asn Gly Asp Leu Ser Asn Lys 
        275                 280                 285             


Ile Leu Lys Ile Thr Asp Phe Gly Leu Ala Arg Glu Trp His Arg Thr 
    290                 295                 300                 


Thr Lys Met Ser Ala Ala Gly Thr Tyr Ala Trp Met Ala Pro Glu Val 
305                 310                 315                 320 


Ile Arg Ala Ser Met Phe Ser Lys Gly Ser Asp Val Trp Ser Tyr Gly 
                325                 330                 335     


Val Leu Leu Trp Glu Leu Leu Thr Gly Glu Val Pro Phe Arg Gly Ile 
            340                 345                 350         


Asp Gly Leu Ala Val Ala Tyr Gly Val Ala Met Asn Lys Leu Ala Leu 
        355                 360                 365             


Pro Ile Pro Ser Thr Cys Pro Glu Pro Phe Ala Lys Leu Met Glu Asp 
    370                 375                 380                 


Cys Trp Asn Pro Asp Pro His Ser Arg Pro Ser Phe Thr Asn Ile Leu 
385                 390                 395                 400 


Asp Gln Leu Thr Thr Ile Glu Glu Ser Gly Phe Phe Glu Met Pro Lys 
                405                 410                 415     


Asp Ser Phe His Cys Leu Gln Asp Asn Trp Lys His Glu Ile Gln Glu 
            420                 425                 430         


Met Phe Asp Gln Leu Arg Ala Lys Glu Lys Glu Leu Arg Thr Trp Glu 
        435                 440                 445             


Glu Glu Leu Thr Arg Ala Ala Leu Gln Gln Lys Asn Gln Glu Glu Leu 
    450                 455                 460                 


Leu Arg Arg Arg Glu Gln Glu Leu Ala Glu Arg Glu Ile Asp Ile Leu 
465                 470                 475                 480 


Glu Arg Glu Leu Asn Ile Ile Ile His Gln Leu Cys Gln Glu Lys Pro 
                485                 490                 495     


Arg Val Lys Lys Arg Lys Gly Lys Phe Arg Lys Ser Arg Leu Lys Leu 
            500                 505                 510         


Lys Asp Gly Asn Arg Ile Ser Leu Pro Ser Asp Phe Gln His Lys Phe 
        515                 520                 525             


Thr Val Gln Ala Ser Pro Thr Met Asp Lys Arg Lys Ser Leu Ile Asn 
    530                 535                 540                 


Ser Arg Ser Ser Pro Pro Ala Ser Pro Thr Ile Ile Pro Arg Leu Arg 
545                 550                 555                 560 


Ala Ile Gln Leu Thr Pro Gly Glu Ser Ser Lys Thr Trp Gly Arg Ser 
                565                 570                 575     


Ser Val Val Pro Lys Glu Glu Gly Glu Glu Glu Glu Lys Arg Ala Pro 
            580                 585                 590         


Lys Lys Lys Gly Arg Thr Trp Gly Pro Gly Thr Leu Gly Gln Lys Glu 
        595                 600                 605             


Leu Ala Ser Gly Asp Glu Gly Ser Pro Gln Arg Arg Glu Lys Ala Asn 
    610                 615                 620                 


Gly Leu Ser Thr Pro Ser Glu Ser Pro His Phe His Leu Gly Leu Lys 
625                 630                 635                 640 


Ser Leu Val Asp Gly Tyr Lys Gln Trp Ser Ser Ser Ala Pro Asn Leu 
                645                 650                 655     


Val Lys Gly Pro Arg Ser Ser Pro Ala Leu Pro Gly Phe Thr Ser Leu 
            660                 665                 670         


Met Glu Met Ala Leu Leu Ala Ala Ser Trp Val Val Pro Ile Asp Ile 
        675                 680                 685             


Glu Glu Asp Glu Asp Ser Glu Gly Pro Gly Ser Gly Glu Ser Arg Leu 
    690                 695                 700                 


Gln His Ser Pro Ser Gln Ser Tyr Leu Cys Ile Pro Phe Pro Arg Gly 
705                 710                 715                 720 


Glu Asp Gly Asp Gly Pro Ser Ser Asp Gly Ile His Glu Glu Pro Thr 
                725                 730                 735     


Pro Val Asn Ser Ala Thr Ser Thr Pro Gln Leu Thr Pro Thr Asn Ser 
            740                 745                 750         


Leu Lys Arg Gly Gly Ala His His Arg Arg Cys Glu Val Ala Leu Leu 
        755                 760                 765             


Gly Cys Gly Ala Val Leu Ala Ala Thr Gly Leu Gly Phe Asp Leu Leu 
    770                 775                 780                 


Glu Ala Gly Lys Cys Gln Leu Leu Pro Leu Glu Glu Pro Glu Pro Pro 
785                 790                 795                 800 


Ala Arg Glu Glu Lys Lys Arg Arg Glu Gly Leu Phe Gln Arg Ser Ser 
                805                 810                 815     


Arg Pro Arg Arg Ser Thr Ser Pro Pro Ser Arg Lys Leu Phe Lys Lys 
            820                 825                 830         


Glu Glu Pro Met Leu Leu Leu Gly Asp Pro Ser Ala Ser Leu Thr Leu 
        835                 840                 845             


Leu Ser Leu Ser Ser Ile Ser Glu Cys Asn Ser Thr Arg Ser Leu Leu 
    850                 855                 860                 


Arg Ser Asp Ser Asp Glu Ile Val Val Tyr Glu Met Pro Val Ser Pro 
865                 870                 875                 880 


Val Glu Ala Pro Pro Leu Ser Pro Cys Thr His Asn Pro Leu Val Asn 
                885                 890                 895     


Val Arg Val Glu Arg Phe Lys Arg Asp Pro Asn Gln Ser Leu Thr Pro 
            900                 905                 910         


Thr His Val Thr Leu Thr Thr Pro Ser Gln Pro Ser Ser His Arg Arg 
        915                 920                 925             


Thr Pro Ser Asp Gly Ala Leu Lys Pro Glu Thr Leu Leu Ala Ser Arg 
    930                 935                 940                 


Ser Pro Ser Ser Asn Gly Leu Ser Pro Ser Pro Gly Ala Gly Met Leu 
945                 950                 955                 960 


Lys Thr Pro Ser Pro Ser Arg Asp Pro Gly Glu Phe Pro Arg Leu Pro 
                965                 970                 975     


Asp Pro Asn Val Val Phe Pro Pro Thr Pro Arg Arg Trp Asn Thr Gln 
            980                 985                 990         


Gln Asp Ser Thr Leu Glu Arg Pro  Lys Thr Leu Glu Phe  Leu Pro Arg 
        995                 1000                 1005             


Pro Arg  Pro Ser Ala Asn Arg  Gln Arg Leu Asp Pro  Trp Trp Phe 
    1010                 1015                 1020             


Val Ser  Pro Ser His Ala Arg  Ser Thr Ser Pro Ala  Asn Ser Ser 
    1025                 1030                 1035             


Ser Thr  Glu Thr Pro Ser Asn  Leu Asp Ser Cys Phe  Ala Ser Ser 
    1040                 1045                 1050             


Ser Ser  Thr Val Glu Glu Arg  Pro Gly Leu Pro Ala  Leu Leu Pro 
    1055                 1060                 1065             


Phe Gln  Ala Gly Pro Leu Pro  Pro Thr Glu Arg Thr  Leu Leu Asp 
    1070                 1075                 1080             


Leu Asp  Ala Glu Gly Gln Ser  Gln Asp Ser Thr Val  Pro Leu Cys 
    1085                 1090                 1095             


Arg Ala  Glu Leu Asn Thr His  Arg Pro Ala Pro Tyr  Glu Ile Gln 
    1100                 1105                 1110             


Gln Glu  Phe Trp Ser 
    1115             


<210>  8315
<211>  1104
<212>  PRT
<213>  Homo Sapiens

<400>  8315

Met Glu Pro Ser Arg Ala Leu Leu Gly Cys Leu Ala Ser Ala Ala Ala 
1               5                   10                  15      


Ala Ala Pro Pro Gly Glu Asp Gly Ala Gly Ala Gly Ala Glu Glu Glu 
            20                  25                  30          


Glu Glu Glu Glu Glu Glu Ala Ala Ala Ala Val Gly Pro Gly Glu Leu 
        35                  40                  45              


Gly Cys Asp Ala Pro Leu Pro Tyr Trp Thr Ala Val Phe Glu Tyr Glu 
    50                  55                  60                  


Ala Ala Gly Glu Asp Glu Leu Thr Leu Arg Leu Gly Asp Val Val Glu 
65                  70                  75                  80  


Val Leu Ser Lys Asp Ser Gln Val Ser Gly Asp Glu Gly Trp Trp Thr 
                85                  90                  95      


Gly Gln Leu Asn Gln Arg Val Gly Ile Phe Pro Ser Asn Tyr Val Thr 
            100                 105                 110         


Pro Arg Ser Ala Phe Ser Ser Arg Cys Gln Pro Gly Gly Glu Asp Pro 
        115                 120                 125             


Ser Cys Tyr Pro Pro Ile Gln Leu Leu Glu Ile Asp Phe Ala Glu Leu 
    130                 135                 140                 


Thr Leu Glu Glu Ile Ile Gly Ile Gly Gly Phe Gly Lys Val Tyr Arg 
145                 150                 155                 160 


Ala Phe Trp Ile Gly Asp Glu Val Ala Val Lys Ala Ala Arg His Asp 
                165                 170                 175     


Pro Asp Glu Asp Ile Ser Gln Thr Ile Glu Asn Val Arg Gln Glu Ala 
            180                 185                 190         


Lys Leu Phe Ala Met Leu Lys His Pro Asn Ile Ile Ala Leu Arg Gly 
        195                 200                 205             


Val Cys Leu Lys Glu Pro Asn Leu Cys Leu Val Met Glu Phe Ala Arg 
    210                 215                 220                 


Gly Gly Pro Leu Asn Arg Val Leu Ser Gly Lys Arg Ile Pro Pro Asp 
225                 230                 235                 240 


Ile Leu Val Asn Trp Ala Val Gln Ile Ala Arg Gly Met Asn Tyr Leu 
                245                 250                 255     


His Asp Glu Ala Ile Val Pro Ile Ile His Arg Asp Leu Lys Ser Ser 
            260                 265                 270         


Asn Ile Leu Ile Leu Gln Lys Val Glu Asn Gly Asp Leu Ser Asn Lys 
        275                 280                 285             


Ile Leu Lys Ile Thr Asp Phe Gly Leu Ala Arg Glu Trp His Arg Thr 
    290                 295                 300                 


Thr Lys Met Ser Ala Ala Gly Thr Tyr Ala Trp Met Ala Pro Glu Val 
305                 310                 315                 320 


Ile Arg Ala Ser Met Phe Ser Lys Gly Ser Asp Val Trp Ser Tyr Gly 
                325                 330                 335     


Val Leu Leu Trp Glu Leu Leu Thr Gly Glu Val Pro Phe Arg Gly Ile 
            340                 345                 350         


Asp Gly Leu Ala Val Ala Tyr Gly Val Ala Met Asn Lys Leu Ala Leu 
        355                 360                 365             


Pro Ile Pro Ser Thr Cys Pro Glu Pro Phe Ala Lys Leu Met Glu Asp 
    370                 375                 380                 


Cys Trp Asn Pro Asp Pro His Ser Arg Pro Ser Phe Thr Asn Ile Leu 
385                 390                 395                 400 


Asp Gln Leu Thr Thr Ile Glu Glu Ser Gly Phe Phe Glu Met Pro Lys 
                405                 410                 415     


Asp Ser Phe His Cys Leu Gln Asp Asn Trp Lys His Glu Ile Gln Glu 
            420                 425                 430         


Met Phe Asp Gln Leu Arg Ala Lys Glu Lys Glu Leu Arg Thr Trp Glu 
        435                 440                 445             


Glu Glu Leu Thr Arg Ala Ala Leu Gln Gln Lys Asn Gln Glu Glu Leu 
    450                 455                 460                 


Leu Arg Arg Arg Glu Gln Glu Leu Ala Glu Arg Glu Ile Asp Ile Leu 
465                 470                 475                 480 


Glu Arg Glu Leu Asn Ile Ile Ile His Gln Leu Cys Gln Glu Lys Pro 
                485                 490                 495     


Arg Val Lys Lys Arg Lys Gly Lys Phe Arg Lys Ser Arg Leu Lys Leu 
            500                 505                 510         


Lys Asp Gly Asn Arg Ile Ser Leu Pro Ser Asp Phe Gln His Lys Phe 
        515                 520                 525             


Thr Val Gln Ala Ser Pro Thr Met Asp Lys Arg Lys Ser Leu Ile Asn 
    530                 535                 540                 


Ser Arg Ser Ser Pro Pro Ala Ser Pro Thr Ile Ile Pro Arg Leu Arg 
545                 550                 555                 560 


Ala Ile Gln Leu Thr Pro Gly Glu Ser Ser Lys Thr Trp Gly Arg Ser 
                565                 570                 575     


Ser Val Val Pro Lys Glu Glu Gly Glu Glu Glu Glu Lys Arg Ala Pro 
            580                 585                 590         


Lys Lys Lys Gly Arg Thr Trp Gly Pro Gly Thr Leu Gly Gln Lys Glu 
        595                 600                 605             


Leu Ala Ser Gly Asp Glu Gly Ser Pro Gln Arg Arg Glu Lys Ala Asn 
    610                 615                 620                 


Gly Leu Ser Thr Pro Ser Glu Ser Pro His Phe His Leu Gly Leu Lys 
625                 630                 635                 640 


Ser Leu Val Asp Gly Tyr Lys Gln Trp Ser Ser Ser Ala Pro Asn Leu 
                645                 650                 655     


Val Lys Gly Pro Arg Ser Ser Pro Ala Leu Pro Gly Phe Thr Ser Leu 
            660                 665                 670         


Met Glu Met Glu Asp Glu Asp Ser Glu Gly Pro Gly Ser Gly Glu Ser 
        675                 680                 685             


Arg Leu Gln His Ser Pro Ser Gln Ser Tyr Leu Cys Ile Pro Phe Pro 
    690                 695                 700                 


Arg Gly Glu Asp Gly Asp Gly Pro Ser Ser Asp Gly Ile His Glu Glu 
705                 710                 715                 720 


Pro Thr Pro Val Asn Ser Ala Thr Ser Thr Pro Gln Leu Thr Pro Thr 
                725                 730                 735     


Asn Ser Leu Lys Arg Gly Gly Ala His His Arg Arg Cys Glu Val Ala 
            740                 745                 750         


Leu Leu Gly Cys Gly Ala Val Leu Ala Ala Thr Gly Leu Gly Phe Asp 
        755                 760                 765             


Leu Leu Glu Ala Gly Lys Cys Gln Leu Leu Pro Leu Glu Glu Pro Glu 
    770                 775                 780                 


Pro Pro Ala Arg Glu Glu Lys Lys Arg Arg Glu Gly Leu Phe Gln Arg 
785                 790                 795                 800 


Ser Ser Arg Pro Arg Arg Ser Thr Ser Pro Pro Ser Arg Lys Leu Phe 
                805                 810                 815     


Lys Lys Glu Glu Pro Met Leu Leu Leu Gly Asp Pro Ser Ala Ser Leu 
            820                 825                 830         


Thr Leu Leu Ser Leu Ser Ser Ile Ser Glu Cys Asn Ser Thr Arg Ser 
        835                 840                 845             


Leu Leu Arg Ser Asp Ser Asp Glu Ile Val Val Tyr Glu Met Pro Val 
    850                 855                 860                 


Ser Pro Val Glu Ala Pro Pro Leu Ser Pro Cys Thr His Asn Pro Leu 
865                 870                 875                 880 


Val Asn Val Arg Val Glu Arg Phe Lys Arg Asp Pro Asn Gln Ser Leu 
                885                 890                 895     


Thr Pro Thr His Val Thr Leu Thr Thr Pro Ser Gln Pro Ser Ser His 
            900                 905                 910         


Arg Arg Thr Pro Ser Asp Gly Ala Leu Lys Pro Glu Thr Leu Leu Ala 
        915                 920                 925             


Ser Arg Ser Pro Ser Ser Asn Gly Leu Ser Pro Ser Pro Gly Ala Gly 
    930                 935                 940                 


Met Leu Lys Thr Pro Ser Pro Ser Arg Asp Pro Gly Glu Phe Pro Arg 
945                 950                 955                 960 


Leu Pro Asp Pro Asn Val Val Phe Pro Pro Thr Pro Arg Arg Trp Asn 
                965                 970                 975     


Thr Gln Gln Asp Ser Thr Leu Glu Arg Pro Lys Thr Leu Glu Phe Leu 
            980                 985                 990         


Pro Arg Pro Arg Pro Ser Ala Asn  Arg Gln Arg Leu Asp  Pro Trp Trp 
        995                 1000                 1005             


Phe Val  Ser Pro Ser His Ala  Arg Ser Thr Ser Pro  Ala Asn Ser 
    1010                 1015                 1020             


Ser Ser  Thr Glu Thr Pro Ser  Asn Leu Asp Ser Cys  Phe Ala Ser 
    1025                 1030                 1035             


Ser Ser  Ser Thr Val Glu Glu  Arg Pro Gly Leu Pro  Ala Leu Leu 
    1040                 1045                 1050             


Pro Phe  Gln Ala Gly Pro Leu  Pro Pro Thr Glu Arg  Thr Leu Leu 
    1055                 1060                 1065             


Asp Leu  Asp Ala Glu Gly Gln  Ser Gln Asp Ser Thr  Val Pro Leu 
    1070                 1075                 1080             


Cys Arg  Ala Glu Leu Asn Thr  His Arg Pro Ala Pro  Tyr Glu Ile 
    1085                 1090                 1095             


Gln Gln  Glu Phe Trp Ser 
    1100                 


<210>  8316
<211>  837
<212>  PRT
<213>  Homo Sapiens

<400>  8316

Met Ser Ala Ala Gly Thr Tyr Ala Trp Met Ala Pro Glu Val Ile Arg 
1               5                   10                  15      


Ala Ser Met Phe Ser Lys Gly Ser Asp Val Trp Ser Tyr Gly Val Leu 
            20                  25                  30          


Leu Trp Glu Leu Leu Thr Gly Glu Val Pro Phe Arg Gly Ile Asp Gly 
        35                  40                  45              


Leu Ala Val Ala Tyr Gly Val Ala Met Asn Lys Leu Ala Leu Pro Ile 
    50                  55                  60                  


Pro Ser Thr Cys Pro Glu Pro Phe Ala Lys Leu Met Glu Asp Cys Trp 
65                  70                  75                  80  


Asn Pro Asp Pro His Ser Arg Pro Ser Phe Thr Asn Ile Leu Asp Gln 
                85                  90                  95      


Leu Thr Thr Ile Glu Glu Ser Gly Phe Phe Glu Met Pro Lys Asp Ser 
            100                 105                 110         


Phe His Cys Leu Gln Asp Asn Trp Lys His Glu Ile Gln Glu Met Phe 
        115                 120                 125             


Asp Gln Leu Arg Ala Lys Glu Lys Glu Leu Arg Thr Trp Glu Glu Glu 
    130                 135                 140                 


Leu Thr Arg Ala Ala Leu Gln Gln Lys Asn Gln Glu Glu Leu Leu Arg 
145                 150                 155                 160 


Arg Arg Glu Gln Glu Leu Ala Glu Arg Glu Ile Asp Ile Leu Glu Arg 
                165                 170                 175     


Glu Leu Asn Ile Ile Ile His Gln Leu Cys Gln Glu Lys Pro Arg Val 
            180                 185                 190         


Lys Lys Arg Lys Gly Lys Phe Arg Lys Ser Arg Leu Lys Leu Lys Asp 
        195                 200                 205             


Gly Asn Arg Ile Ser Leu Pro Ser Asp Phe Gln His Lys Phe Thr Val 
    210                 215                 220                 


Gln Ala Ser Pro Thr Met Asp Lys Arg Lys Ser Leu Ile Asn Ser Arg 
225                 230                 235                 240 


Ser Ser Pro Pro Ala Ser Pro Thr Ile Ile Pro Arg Leu Arg Ala Ile 
                245                 250                 255     


Gln Cys Glu Thr Val Ser Gln Ile Ser Trp Gly Gln Asn Thr Gln Gly 
            260                 265                 270         


His Leu Ser Pro Ala Leu Ser Ser His Arg Leu Val Gln Ala Cys Ser 
        275                 280                 285             


Ile His Asn Phe Cys His Leu Ser Ser Thr Met Cys Ile Tyr Met His 
    290                 295                 300                 


Ile Leu Thr Pro Gly Glu Ser Ser Lys Thr Trp Gly Arg Ser Ser Val 
305                 310                 315                 320 


Val Pro Lys Glu Glu Gly Glu Glu Glu Glu Lys Arg Ala Pro Lys Lys 
                325                 330                 335     


Lys Gly Arg Thr Trp Gly Pro Gly Thr Leu Gly Gln Lys Glu Leu Ala 
            340                 345                 350         


Ser Gly Asp Glu Gly Leu Lys Ser Leu Val Asp Gly Tyr Lys Gln Trp 
        355                 360                 365             


Ser Ser Ser Ala Pro Asn Leu Val Lys Gly Pro Arg Ser Ser Pro Ala 
    370                 375                 380                 


Leu Pro Gly Phe Thr Ser Leu Met Glu Met Ala Leu Leu Ala Ala Ser 
385                 390                 395                 400 


Trp Val Val Pro Ile Asp Ile Glu Glu Asp Glu Asp Ser Glu Gly Pro 
                405                 410                 415     


Gly Ser Gly Glu Ser Arg Leu Gln His Ser Pro Ser Gln Ser Tyr Leu 
            420                 425                 430         


Cys Ile Pro Phe Pro Arg Gly Glu Asp Gly Asp Gly Pro Ser Ser Asp 
        435                 440                 445             


Gly Ile His Glu Glu Pro Thr Pro Val Asn Ser Ala Thr Ser Thr Pro 
    450                 455                 460                 


Gln Leu Thr Pro Thr Asn Ser Leu Lys Arg Gly Gly Ala His His Arg 
465                 470                 475                 480 


Arg Cys Glu Val Ala Leu Leu Gly Cys Gly Ala Val Leu Ala Ala Thr 
                485                 490                 495     


Gly Leu Gly Phe Asp Leu Leu Glu Ala Gly Lys Cys Gln Leu Leu Pro 
            500                 505                 510         


Leu Glu Glu Pro Glu Pro Pro Ala Arg Glu Glu Lys Lys Arg Arg Glu 
        515                 520                 525             


Gly Leu Phe Gln Arg Ser Ser Arg Pro Arg Arg Ser Thr Ser Pro Pro 
    530                 535                 540                 


Ser Arg Lys Leu Phe Lys Lys Glu Glu Pro Met Leu Leu Leu Gly Asp 
545                 550                 555                 560 


Pro Ser Ala Ser Leu Thr Leu Leu Ser Leu Ser Ser Ile Ser Glu Cys 
                565                 570                 575     


Asn Ser Thr Arg Ser Leu Leu Arg Ser Asp Ser Asp Glu Ile Val Val 
            580                 585                 590         


Tyr Glu Met Pro Val Ser Pro Val Glu Ala Pro Pro Leu Ser Pro Cys 
        595                 600                 605             


Thr His Asn Pro Leu Val Asn Val Arg Val Glu Arg Phe Lys Arg Asp 
    610                 615                 620                 


Pro Asn Gln Ser Leu Thr Pro Thr His Val Thr Leu Thr Thr Pro Ser 
625                 630                 635                 640 


Gln Pro Ser Ser His Arg Arg Thr Pro Ser Asp Gly Ala Leu Lys Pro 
                645                 650                 655     


Glu Thr Leu Leu Ala Ser Arg Ser Pro Ser Ser Asn Gly Leu Ser Pro 
            660                 665                 670         


Ser Pro Gly Ala Gly Met Leu Lys Thr Pro Ser Pro Ser Arg Asp Pro 
        675                 680                 685             


Gly Glu Phe Pro Arg Leu Pro Asp Pro Asn Val Val Phe Pro Pro Thr 
    690                 695                 700                 


Pro Arg Arg Trp Asn Thr Gln Gln Asp Ser Thr Leu Glu Arg Pro Lys 
705                 710                 715                 720 


Thr Leu Glu Phe Leu Pro Arg Pro Arg Pro Ser Ala Asn Arg Gln Arg 
                725                 730                 735     


Leu Asp Pro Trp Trp Phe Val Ser Pro Ser His Ala Arg Ser Thr Ser 
            740                 745                 750         


Pro Ala Asn Ser Ser Ser Thr Glu Thr Pro Ser Asn Leu Asp Ser Cys 
        755                 760                 765             


Phe Ala Ser Ser Ser Ser Thr Val Glu Glu Arg Pro Gly Leu Pro Ala 
    770                 775                 780                 


Leu Leu Pro Phe Gln Ala Gly Pro Leu Pro Pro Thr Glu Arg Thr Leu 
785                 790                 795                 800 


Leu Asp Leu Asp Ala Glu Gly Gln Ser Gln Asp Ser Thr Val Pro Leu 
                805                 810                 815     


Cys Arg Ala Glu Leu Asn Thr His Arg Pro Ala Pro Tyr Glu Ile Gln 
            820                 825                 830         


Gln Glu Phe Trp Ser 
        835         


<210>  8317
<211>  55
<212>  PRT
<213>  Homo Sapiens

<400>  8317

Met Phe Gly Gln Ile Gln Ser Pro Gly Tyr Pro Asp Ser Tyr Pro Ser 
1               5                   10                  15      


Asp Ser Glu Val Thr Trp Asn Ile Thr Val Pro Asp Gly Phe Arg Ile 
            20                  25                  30          


Lys Leu Tyr Phe Met His Phe Asn Leu Glu Ser Ser Tyr Leu Cys Glu 
        35                  40                  45              


Tyr Asp Tyr Val Lys Val Glu 
    50                  55  


<210>  8318
<211>  354
<212>  PRT
<213>  Homo Sapiens

<400>  8318

Met Phe Gly Gln Ile Gln Ser Pro Gly Tyr Pro Asp Ser Tyr Pro Ser 
1               5                   10                  15      


Asp Ser Glu Val Thr Trp Asn Ile Thr Val Pro Asp Gly Phe Arg Ile 
            20                  25                  30          


Lys Leu Tyr Phe Met His Phe Asn Leu Glu Ser Ser Tyr Leu Cys Glu 
        35                  40                  45              


Tyr Asp Tyr Val Lys Val Glu Thr Glu Asp Gln Val Leu Ala Thr Phe 
    50                  55                  60                  


Cys Gly Arg Glu Thr Thr Asp Thr Glu Gln Thr Pro Gly Gln Glu Val 
65                  70                  75                  80  


Val Leu Ser Pro Gly Ser Phe Met Ser Ile Thr Phe Arg Ser Asp Phe 
                85                  90                  95      


Ser Asn Glu Glu Arg Phe Thr Gly Phe Asp Ala His Tyr Met Ala Val 
            100                 105                 110         


Asp Val Asp Glu Cys Lys Glu Arg Glu Asp Glu Glu Leu Ser Cys Asp 
        115                 120                 125             


His Tyr Cys His Asn Tyr Ile Gly Gly Tyr Tyr Cys Ser Cys Arg Phe 
    130                 135                 140                 


Gly Tyr Ile Leu His Thr Asp Asn Arg Thr Cys Arg Val Glu Cys Ser 
145                 150                 155                 160 


Asp Asn Leu Phe Thr Gln Arg Thr Gly Val Ile Thr Ser Pro Asp Phe 
                165                 170                 175     


Pro Asn Pro Tyr Pro Lys Ser Ser Glu Cys Leu Tyr Thr Ile Glu Leu 
            180                 185                 190         


Glu Glu Gly Phe Met Val Asn Leu Gln Phe Glu Asp Ile Phe Asp Ile 
        195                 200                 205             


Glu Asp His Pro Glu Val Pro Cys Pro Tyr Asp Tyr Ile Lys Ile Lys 
    210                 215                 220                 


Val Gly Pro Lys Val Leu Gly Pro Phe Cys Gly Glu Lys Ala Pro Glu 
225                 230                 235                 240 


Pro Ile Ser Thr Gln Ser His Ser Val Leu Ile Leu Phe His Ser Asp 
                245                 250                 255     


Asn Ser Gly Glu Asn Arg Gly Trp Arg Leu Ser Tyr Arg Ala Ala Gly 
            260                 265                 270         


Asn Glu Cys Pro Glu Leu Gln Pro Pro Val His Gly Lys Ile Glu Pro 
        275                 280                 285             


Ser Gln Ala Lys Tyr Phe Phe Lys Asp Gln Val Leu Val Ser Cys Asp 
    290                 295                 300                 


Thr Gly Tyr Lys Val Leu Lys Asp Asn Val Glu Met Asp Thr Phe Gln 
305                 310                 315                 320 


Ile Glu Cys Leu Lys Asp Gly Thr Trp Ser Asn Lys Ile Pro Thr Cys 
                325                 330                 335     


Lys Lys Asn Glu Ile Asp Leu Glu Ser Glu Leu Lys Ser Glu Gln Val 
            340                 345                 350         


Thr Glu 
        


<210>  8319
<211>  118
<212>  PRT
<213>  Homo Sapiens

<400>  8319

Met Pro Ala Asn Ser Arg Asp Thr Gln Gly Pro Gln Asn Lys Asp Lys 
1               5                   10                  15      


Ala Ser Arg Thr Pro His Arg Ala Arg Ala His Arg Trp Leu Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Leu Cys Phe Ser Leu Ser Lys Ala Ser Ala His Thr Val 
        35                  40                  45              


Glu Leu Asn Asn Met Phe Gly Gln Ile Gln Ser Pro Gly Tyr Pro Asp 
    50                  55                  60                  


Ser Tyr Pro Ser Asp Ser Glu Val Thr Trp Asn Ile Thr Val Pro Asp 
65                  70                  75                  80  


Gly Phe Arg Ile Lys Leu Tyr Phe Met His Phe Asn Leu Glu Ser Ser 
                85                  90                  95      


Tyr Leu Cys Glu Tyr Asp Tyr Val Lys Val Glu Thr Glu Asp Gln Val 
            100                 105                 110         


Leu Ala Thr Phe Cys Gly 
        115             


<210>  8320
<211>  205
<212>  PRT
<213>  Homo Sapiens

<400>  8320

Met Arg Pro Thr Phe Met Ser Phe Arg Trp Leu Leu Leu Tyr Tyr Ala 
1               5                   10                  15      


Leu Cys Phe Ser Leu Ser Lys Ala Ser Ala His Thr Val Glu Leu Asn 
            20                  25                  30          


Asn Met Phe Gly Gln Ile Gln Ser Pro Gly Tyr Pro Asp Ser Tyr Pro 
        35                  40                  45              


Ser Asp Ser Glu Val Thr Trp Asn Ile Thr Val Pro Asp Gly Phe Arg 
    50                  55                  60                  


Ile Lys Leu Tyr Phe Met His Phe Asn Leu Glu Ser Ser Tyr Leu Cys 
65                  70                  75                  80  


Glu Tyr Asp Tyr Val Lys Val Glu Thr Glu Asp Gln Val Leu Ala Thr 
                85                  90                  95      


Phe Cys Gly Arg Glu Thr Thr Asp Thr Glu Gln Thr Pro Gly Gln Glu 
            100                 105                 110         


Val Val Leu Ser Pro Gly Ser Phe Met Ser Ile Thr Phe Arg Ser Asp 
        115                 120                 125             


Phe Ser Asn Glu Glu Arg Phe Thr Gly Phe Asp Ala His Tyr Met Ala 
    130                 135                 140                 


Val Asp Val Asp Glu Cys Lys Glu Arg Glu Asp Glu Glu Leu Ser Cys 
145                 150                 155                 160 


Asp His Tyr Cys His Asn Tyr Ile Gly Gly Tyr Tyr Cys Ser Cys Arg 
                165                 170                 175     


Phe Gly Tyr Ile Leu His Thr Asp Asn Arg Thr Cys Arg Val Glu Cys 
            180                 185                 190         


Ser Asp Asn Leu Phe Thr Gln Arg Thr Gly Val Ile Thr 
        195                 200                 205 


<210>  8321
<211>  380
<212>  PRT
<213>  Homo Sapiens

<400>  8321

Met Arg Trp Leu Leu Leu Tyr Tyr Ala Leu Cys Phe Ser Leu Ser Lys 
1               5                   10                  15      


Ala Ser Ala His Thr Val Glu Leu Asn Asn Met Phe Gly Gln Ile Gln 
            20                  25                  30          


Ser Pro Gly Tyr Pro Asp Ser Tyr Pro Ser Asp Ser Glu Val Thr Trp 
        35                  40                  45              


Asn Ile Thr Val Pro Asp Gly Phe Arg Ile Lys Leu Tyr Phe Met His 
    50                  55                  60                  


Phe Asn Leu Glu Ser Ser Tyr Leu Cys Glu Tyr Asp Tyr Val Lys Val 
65                  70                  75                  80  


Glu Thr Glu Asp Gln Val Leu Ala Thr Phe Cys Gly Arg Glu Thr Thr 
                85                  90                  95      


Asp Thr Glu Gln Thr Pro Gly Gln Glu Val Val Leu Ser Pro Gly Ser 
            100                 105                 110         


Phe Met Ser Ile Thr Phe Arg Ser Asp Phe Ser Asn Glu Glu Arg Phe 
        115                 120                 125             


Thr Gly Phe Asp Ala His Tyr Met Ala Val Asp Val Asp Glu Cys Lys 
    130                 135                 140                 


Glu Arg Glu Asp Glu Glu Leu Ser Cys Asp His Tyr Cys His Asn Tyr 
145                 150                 155                 160 


Ile Gly Gly Tyr Tyr Cys Ser Cys Arg Phe Gly Tyr Ile Leu His Thr 
                165                 170                 175     


Asp Asn Arg Thr Cys Arg Val Glu Cys Ser Asp Asn Leu Phe Thr Gln 
            180                 185                 190         


Arg Thr Gly Val Ile Thr Ser Pro Asp Phe Pro Asn Pro Tyr Pro Lys 
        195                 200                 205             


Ser Ser Glu Cys Leu Tyr Thr Ile Glu Leu Glu Glu Gly Phe Met Val 
    210                 215                 220                 


Asn Leu Gln Phe Glu Asp Ile Phe Asp Ile Glu Asp His Pro Glu Val 
225                 230                 235                 240 


Pro Cys Pro Tyr Asp Tyr Ile Lys Ile Lys Val Gly Pro Lys Val Leu 
                245                 250                 255     


Gly Pro Phe Cys Gly Glu Lys Ala Pro Glu Pro Ile Ser Thr Gln Ser 
            260                 265                 270         


His Ser Val Leu Ile Leu Phe His Ser Asp Asn Ser Gly Glu Asn Arg 
        275                 280                 285             


Gly Trp Arg Leu Ser Tyr Arg Ala Ala Gly Asn Glu Cys Pro Glu Leu 
    290                 295                 300                 


Gln Pro Pro Val His Gly Lys Ile Glu Pro Ser Gln Ala Lys Tyr Phe 
305                 310                 315                 320 


Phe Lys Asp Gln Val Leu Val Ser Cys Asp Thr Gly Tyr Lys Val Leu 
                325                 330                 335     


Lys Asp Asn Val Glu Met Asp Thr Phe Gln Ile Glu Cys Leu Lys Asp 
            340                 345                 350         


Gly Thr Trp Ser Asn Lys Ile Pro Thr Cys Lys Lys Asn Glu Ile Asp 
        355                 360                 365             


Leu Glu Ser Glu Leu Lys Ser Glu Gln Val Thr Glu 
    370                 375                 380 


<210>  8322
<211>  728
<212>  PRT
<213>  Homo Sapiens

<400>  8322

Met Arg Trp Leu Leu Leu Tyr Tyr Ala Leu Cys Phe Ser Leu Ser Lys 
1               5                   10                  15      


Ala Ser Ala His Thr Val Glu Leu Asn Asn Met Phe Gly Gln Ile Gln 
            20                  25                  30          


Ser Pro Gly Tyr Pro Asp Ser Tyr Pro Ser Asp Ser Glu Val Thr Trp 
        35                  40                  45              


Asn Ile Thr Val Pro Asp Gly Phe Arg Ile Lys Leu Tyr Phe Met His 
    50                  55                  60                  


Phe Asn Leu Glu Ser Ser Tyr Leu Cys Glu Tyr Asp Tyr Val Lys Val 
65                  70                  75                  80  


Glu Thr Glu Asp Gln Val Leu Ala Thr Phe Cys Gly Arg Glu Thr Thr 
                85                  90                  95      


Asp Thr Glu Gln Thr Pro Gly Gln Glu Val Val Leu Ser Pro Gly Ser 
            100                 105                 110         


Phe Met Ser Ile Thr Phe Arg Ser Asp Phe Ser Asn Glu Glu Arg Phe 
        115                 120                 125             


Thr Gly Phe Asp Ala His Tyr Met Ala Val Asp Val Asp Glu Cys Lys 
    130                 135                 140                 


Glu Arg Glu Asp Glu Glu Leu Ser Cys Asp His Tyr Cys His Asn Tyr 
145                 150                 155                 160 


Ile Gly Gly Tyr Tyr Cys Ser Cys Arg Phe Gly Tyr Ile Leu His Thr 
                165                 170                 175     


Asp Asn Arg Thr Cys Arg Val Glu Cys Ser Asp Asn Leu Phe Thr Gln 
            180                 185                 190         


Arg Thr Gly Val Ile Thr Ser Pro Asp Phe Pro Asn Pro Tyr Pro Lys 
        195                 200                 205             


Ser Ser Glu Cys Leu Tyr Thr Ile Glu Leu Glu Glu Gly Phe Met Val 
    210                 215                 220                 


Asn Leu Gln Phe Glu Asp Ile Phe Asp Ile Glu Asp His Pro Glu Val 
225                 230                 235                 240 


Pro Cys Pro Tyr Asp Tyr Ile Lys Ile Lys Val Gly Pro Lys Val Leu 
                245                 250                 255     


Gly Pro Phe Cys Gly Glu Lys Ala Pro Glu Pro Ile Ser Thr Gln Ser 
            260                 265                 270         


His Ser Val Leu Ile Leu Phe His Ser Asp Asn Ser Gly Glu Asn Arg 
        275                 280                 285             


Gly Trp Arg Leu Ser Tyr Arg Ala Ala Gly Asn Glu Cys Pro Glu Leu 
    290                 295                 300                 


Gln Pro Pro Val His Gly Lys Ile Glu Pro Ser Gln Ala Lys Tyr Phe 
305                 310                 315                 320 


Phe Lys Asp Gln Val Leu Val Ser Cys Asp Thr Gly Tyr Lys Val Leu 
                325                 330                 335     


Lys Asp Asn Val Glu Met Asp Thr Phe Gln Ile Glu Cys Leu Lys Asp 
            340                 345                 350         


Gly Thr Trp Ser Asn Lys Ile Pro Thr Cys Lys Ile Val Asp Cys Arg 
        355                 360                 365             


Ala Pro Gly Glu Leu Glu His Gly Leu Ile Thr Phe Ser Thr Arg Asn 
    370                 375                 380                 


Asn Leu Thr Thr Tyr Lys Ser Glu Ile Lys Tyr Ser Cys Gln Glu Pro 
385                 390                 395                 400 


Tyr Tyr Lys Met Leu Asn Asn Asn Thr Gly Ile Tyr Thr Cys Ser Ala 
                405                 410                 415     


Gln Gly Val Trp Met Asn Lys Val Leu Gly Arg Ser Leu Pro Thr Cys 
            420                 425                 430         


Leu Pro Glu Cys Gly Gln Pro Ser Arg Ser Leu Pro Ser Leu Val Lys 
        435                 440                 445             


Arg Ile Ile Gly Gly Arg Asn Ala Glu Pro Gly Leu Phe Pro Trp Gln 
    450                 455                 460                 


Ala Leu Ile Val Val Glu Asp Thr Ser Arg Val Pro Asn Asp Lys Trp 
465                 470                 475                 480 


Phe Gly Ser Gly Ala Leu Leu Ser Ala Ser Trp Ile Leu Thr Ala Ala 
                485                 490                 495     


His Val Leu Arg Ser Gln Arg Arg Asp Thr Thr Val Ile Pro Val Ser 
            500                 505                 510         


Lys Glu His Val Thr Val Tyr Leu Gly Leu His Asp Val Arg Asp Lys 
        515                 520                 525             


Ser Gly Ala Val Asn Ser Ser Ala Ala Arg Val Val Leu His Pro Asp 
    530                 535                 540                 


Phe Asn Ile Gln Asn Tyr Asn His Asp Ile Ala Leu Val Gln Leu Gln 
545                 550                 555                 560 


Glu Pro Val Pro Leu Gly Pro His Val Met Pro Val Cys Leu Pro Arg 
                565                 570                 575     


Leu Glu Pro Glu Gly Pro Ala Pro His Met Leu Gly Leu Val Ala Gly 
            580                 585                 590         


Trp Gly Ile Ser Asn Pro Asn Val Thr Val Asp Glu Ile Ile Ser Ser 
        595                 600                 605             


Gly Thr Arg Thr Leu Ser Asp Val Leu Gln Tyr Val Lys Leu Pro Val 
    610                 615                 620                 


Val Pro His Ala Glu Cys Lys Thr Ser Tyr Glu Ser Arg Ser Gly Asn 
625                 630                 635                 640 


Tyr Ser Val Thr Glu Asn Met Phe Cys Ala Gly Tyr Tyr Glu Gly Gly 
                645                 650                 655     


Lys Asp Thr Cys Leu Gly Asp Ser Gly Gly Ala Phe Val Ile Phe Asp 
            660                 665                 670         


Asp Leu Ser Gln Arg Trp Val Val Gln Gly Leu Val Ser Trp Gly Gly 
        675                 680                 685             


Pro Glu Glu Cys Gly Ser Lys Gln Val Tyr Gly Val Tyr Thr Lys Val 
    690                 695                 700                 


Ser Asn Tyr Val Asp Trp Val Trp Glu Gln Met Gly Leu Pro Gln Ser 
705                 710                 715                 720 


Val Val Glu Pro Gln Val Glu Arg 
                725             


<210>  8323
<211>  699
<212>  PRT
<213>  Homo Sapiens

<400>  8323

Met Arg Trp Leu Leu Leu Tyr Tyr Ala Leu Cys Phe Ser Leu Ser Lys 
1               5                   10                  15      


Ala Ser Ala His Thr Val Glu Leu Asn Asn Met Phe Gly Gln Ile Gln 
            20                  25                  30          


Ser Pro Gly Tyr Pro Asp Ser Tyr Pro Ser Asp Ser Glu Val Thr Trp 
        35                  40                  45              


Asn Ile Thr Val Pro Asp Gly Phe Arg Ile Lys Leu Tyr Phe Met His 
    50                  55                  60                  


Phe Asn Leu Glu Ser Ser Tyr Leu Cys Glu Tyr Asp Tyr Val Lys Val 
65                  70                  75                  80  


Glu Thr Glu Asp Gln Val Leu Ala Thr Phe Cys Gly Arg Glu Thr Thr 
                85                  90                  95      


Asp Thr Glu Gln Thr Pro Gly Gln Glu Val Val Leu Ser Pro Gly Ser 
            100                 105                 110         


Phe Met Ser Ile Thr Phe Arg Ser Asp Phe Ser Asn Glu Glu Arg Phe 
        115                 120                 125             


Thr Gly Phe Asp Ala His Tyr Met Ala Val Asp Val Asp Glu Cys Lys 
    130                 135                 140                 


Glu Arg Glu Asp Glu Glu Leu Ser Cys Asp His Tyr Cys His Asn Tyr 
145                 150                 155                 160 


Ile Gly Gly Tyr Tyr Cys Ser Cys Arg Phe Gly Tyr Ile Leu His Thr 
                165                 170                 175     


Asp Asn Arg Thr Cys Arg Val Glu Cys Ser Asp Asn Leu Phe Thr Gln 
            180                 185                 190         


Arg Thr Gly Val Ile Thr Ser Pro Asp Phe Pro Asn Pro Tyr Pro Lys 
        195                 200                 205             


Ser Ser Glu Cys Leu Tyr Thr Ile Glu Leu Glu Glu Gly Phe Met Val 
    210                 215                 220                 


Asn Leu Gln Phe Glu Asp Ile Phe Asp Ile Glu Asp His Pro Glu Val 
225                 230                 235                 240 


Pro Cys Pro Tyr Asp Tyr Ile Lys Ile Lys Val Gly Pro Lys Val Leu 
                245                 250                 255     


Gly Pro Phe Cys Gly Glu Lys Ala Pro Glu Pro Ile Ser Thr Gln Ser 
            260                 265                 270         


His Ser Val Leu Ile Leu Phe His Ser Asp Asn Ser Gly Glu Asn Arg 
        275                 280                 285             


Gly Trp Arg Leu Ser Tyr Arg Ala Ala Gly Asn Glu Cys Pro Glu Leu 
    290                 295                 300                 


Gln Pro Pro Val His Gly Lys Ile Glu Pro Ser Gln Ala Lys Tyr Phe 
305                 310                 315                 320 


Phe Lys Asp Gln Val Leu Val Ser Cys Asp Thr Gly Tyr Lys Val Leu 
                325                 330                 335     


Lys Asp Asn Val Glu Met Asp Thr Phe Gln Ile Glu Cys Leu Lys Asp 
            340                 345                 350         


Gly Thr Trp Ser Asn Lys Ile Pro Thr Cys Lys Ile Val Asp Cys Arg 
        355                 360                 365             


Ala Pro Gly Glu Leu Glu His Gly Leu Ile Thr Phe Ser Thr Arg Asn 
    370                 375                 380                 


Asn Leu Thr Thr Tyr Lys Ser Glu Ile Lys Tyr Ser Cys Gln Glu Pro 
385                 390                 395                 400 


Tyr Tyr Lys Met Leu Asn Asn Asn Thr Gly Ile Tyr Thr Cys Ser Ala 
                405                 410                 415     


Gln Gly Val Trp Met Asn Lys Val Leu Gly Arg Ser Leu Pro Thr Cys 
            420                 425                 430         


Leu Pro Val Cys Gly Leu Pro Lys Phe Ser Arg Lys Leu Met Ala Arg 
        435                 440                 445             


Ile Phe Asn Gly Arg Pro Ala Gln Lys Gly Thr Thr Pro Trp Ile Ala 
    450                 455                 460                 


Met Leu Ser His Leu Asn Gly Gln Pro Phe Cys Gly Gly Ser Leu Leu 
465                 470                 475                 480 


Gly Ser Ser Trp Ile Val Thr Ala Ala His Cys Leu His Gln Ser Leu 
                485                 490                 495     


Asp Pro Glu Asp Pro Thr Leu Arg Asp Ser Asp Leu Leu Ser Pro Ser 
            500                 505                 510         


Asp Phe Lys Ile Ile Leu Gly Lys His Trp Arg Leu Arg Ser Asp Glu 
        515                 520                 525             


Asn Glu Gln His Leu Gly Val Lys His Thr Thr Leu His Pro Gln Tyr 
    530                 535                 540                 


Asp Pro Asn Thr Phe Glu Asn Asp Val Ala Leu Val Glu Leu Leu Glu 
545                 550                 555                 560 


Ser Pro Val Leu Asn Ala Phe Val Met Pro Ile Cys Leu Pro Glu Gly 
                565                 570                 575     


Pro Gln Gln Glu Gly Ala Met Val Ile Val Ser Gly Trp Gly Lys Gln 
            580                 585                 590         


Phe Leu Gln Arg Phe Pro Glu Thr Leu Met Glu Ile Glu Ile Pro Ile 
        595                 600                 605             


Val Asp His Ser Thr Cys Gln Lys Ala Tyr Ala Pro Leu Lys Lys Lys 
    610                 615                 620                 


Val Thr Arg Asp Met Ile Cys Ala Gly Glu Lys Glu Gly Gly Lys Asp 
625                 630                 635                 640 


Ala Cys Ala Gly Asp Ser Gly Gly Pro Met Val Thr Leu Asn Arg Glu 
                645                 650                 655     


Arg Gly Gln Trp Tyr Leu Val Gly Thr Val Ser Trp Gly Asp Asp Cys 
            660                 665                 670         


Gly Lys Lys Asp Arg Tyr Gly Val Tyr Ser Tyr Ile His His Asn Lys 
        675                 680                 685             


Asp Trp Ile Gln Arg Val Thr Gly Val Arg Asn 
    690                 695                 


<210>  8324
<211>  615
<212>  PRT
<213>  Homo Sapiens

<400>  8324

Met Ser Ile Thr Phe Arg Ser Asp Phe Ser Asn Glu Glu Arg Phe Thr 
1               5                   10                  15      


Gly Phe Asp Ala His Tyr Met Ala Val Asp Val Asp Glu Cys Lys Glu 
            20                  25                  30          


Arg Glu Asp Glu Glu Leu Ser Cys Asp His Tyr Cys His Asn Tyr Ile 
        35                  40                  45              


Gly Gly Tyr Tyr Cys Ser Cys Arg Phe Gly Tyr Ile Leu His Thr Asp 
    50                  55                  60                  


Asn Arg Thr Cys Arg Val Glu Cys Ser Asp Asn Leu Phe Thr Gln Arg 
65                  70                  75                  80  


Thr Gly Val Ile Thr Ser Pro Asp Phe Pro Asn Pro Tyr Pro Lys Ser 
                85                  90                  95      


Ser Glu Cys Leu Tyr Thr Ile Glu Leu Glu Glu Gly Phe Met Val Asn 
            100                 105                 110         


Leu Gln Phe Glu Asp Ile Phe Asp Ile Glu Asp His Pro Glu Val Pro 
        115                 120                 125             


Cys Pro Tyr Asp Tyr Ile Lys Ile Lys Val Gly Pro Lys Val Leu Gly 
    130                 135                 140                 


Pro Phe Cys Gly Glu Lys Ala Pro Glu Pro Ile Ser Thr Gln Ser His 
145                 150                 155                 160 


Ser Val Leu Ile Leu Phe His Ser Asp Asn Ser Gly Glu Asn Arg Gly 
                165                 170                 175     


Trp Arg Leu Ser Tyr Arg Ala Ala Gly Asn Glu Cys Pro Glu Leu Gln 
            180                 185                 190         


Pro Pro Val His Gly Lys Ile Glu Pro Ser Gln Ala Lys Tyr Phe Phe 
        195                 200                 205             


Lys Asp Gln Val Leu Val Ser Cys Asp Thr Gly Tyr Lys Val Leu Lys 
    210                 215                 220                 


Asp Asn Val Glu Met Asp Thr Phe Gln Ile Glu Cys Leu Lys Asp Gly 
225                 230                 235                 240 


Thr Trp Ser Asn Lys Ile Pro Thr Cys Lys Ile Val Asp Cys Arg Ala 
                245                 250                 255     


Pro Gly Glu Leu Glu His Gly Leu Ile Thr Phe Ser Thr Arg Asn Asn 
            260                 265                 270         


Leu Thr Thr Tyr Lys Ser Glu Ile Lys Tyr Ser Cys Gln Glu Pro Tyr 
        275                 280                 285             


Tyr Lys Met Leu Asn Asn Asn Thr Gly Ile Tyr Thr Cys Ser Ala Gln 
    290                 295                 300                 


Gly Val Trp Met Asn Lys Val Leu Gly Arg Ser Leu Pro Thr Cys Leu 
305                 310                 315                 320 


Pro Glu Cys Gly Gln Pro Ser Arg Ser Leu Pro Ser Leu Val Lys Arg 
                325                 330                 335     


Ile Ile Gly Gly Arg Asn Ala Glu Pro Gly Leu Phe Pro Trp Gln Ala 
            340                 345                 350         


Leu Ile Val Val Glu Asp Thr Ser Arg Val Pro Asn Asp Lys Trp Phe 
        355                 360                 365             


Gly Ser Gly Ala Leu Leu Ser Ala Ser Trp Ile Leu Thr Ala Ala His 
    370                 375                 380                 


Val Leu Arg Ser Gln Arg Arg Asp Thr Thr Val Ile Pro Val Ser Lys 
385                 390                 395                 400 


Glu His Val Thr Val Tyr Leu Gly Leu His Asp Val Arg Asp Lys Ser 
                405                 410                 415     


Gly Ala Val Asn Ser Ser Ala Ala Arg Val Val Leu His Pro Asp Phe 
            420                 425                 430         


Asn Ile Gln Asn Tyr Asn His Asp Ile Ala Leu Val Gln Leu Gln Glu 
        435                 440                 445             


Pro Val Pro Leu Gly Pro His Val Met Pro Val Cys Leu Pro Arg Leu 
    450                 455                 460                 


Glu Pro Glu Gly Pro Ala Pro His Met Leu Gly Leu Val Ala Gly Trp 
465                 470                 475                 480 


Gly Ile Ser Asn Pro Asn Val Thr Val Asp Glu Ile Ile Ser Ser Gly 
                485                 490                 495     


Thr Arg Thr Leu Ser Asp Val Leu Gln Tyr Val Lys Leu Pro Val Val 
            500                 505                 510         


Pro His Ala Glu Cys Lys Thr Ser Tyr Glu Ser Arg Ser Gly Asn Tyr 
        515                 520                 525             


Ser Val Thr Glu Asn Met Phe Cys Ala Gly Tyr Tyr Glu Gly Gly Lys 
    530                 535                 540                 


Asp Thr Cys Leu Gly Asp Ser Gly Gly Ala Phe Val Ile Phe Asp Asp 
545                 550                 555                 560 


Leu Ser Gln Arg Trp Val Val Gln Gly Leu Val Ser Trp Gly Gly Pro 
                565                 570                 575     


Glu Glu Cys Gly Ser Lys Gln Val Tyr Gly Val Tyr Thr Lys Val Ser 
            580                 585                 590         


Asn Tyr Val Asp Trp Val Trp Glu Gln Met Gly Leu Pro Gln Ser Val 
        595                 600                 605             


Val Glu Pro Gln Val Glu Arg 
    610                 615 


<210>  8325
<211>  686
<212>  PRT
<213>  Homo Sapiens

<400>  8325

Met Arg Leu Leu Thr Leu Leu Gly Leu Leu Cys Gly Ser Val Ala Thr 
1               5                   10                  15      


Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala Ser 
            20                  25                  30          


Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp Thr 
        35                  40                  45              


Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His Phe 
    50                  55                  60                  


Asp Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu Ser 
65                  70                  75                  80  


Ser Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr Asp 
                85                  90                  95      


Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser Ser 
            100                 105                 110         


Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe Thr 
        115                 120                 125             


Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Ile Asp Glu Cys Gln Val 
    130                 135                 140                 


Ala Pro Gly Glu Ala Pro Thr Cys Asp His His Cys His Asn His Leu 
145                 150                 155                 160 


Gly Gly Phe Tyr Cys Ser Cys Arg Ala Gly Tyr Val Leu His Arg Asn 
                165                 170                 175     


Lys Arg Thr Cys Ser Ala Leu Cys Ser Gly Gln Val Phe Thr Gln Arg 
            180                 185                 190         


Ser Gly Glu Leu Ser Ser Pro Glu Tyr Pro Arg Pro Tyr Pro Lys Leu 
        195                 200                 205             


Ser Ser Cys Thr Tyr Ser Ile Ser Leu Glu Glu Gly Phe Ser Val Ile 
    210                 215                 220                 


Leu Asp Phe Val Glu Ser Phe Asp Val Glu Thr His Pro Glu Thr Leu 
225                 230                 235                 240 


Cys Pro Tyr Asp Phe Leu Lys Ile Gln Thr Asp Arg Glu Glu His Gly 
                245                 250                 255     


Pro Phe Cys Gly Lys Thr Leu Pro His Arg Ile Glu Thr Lys Ser Asn 
            260                 265                 270         


Thr Val Thr Ile Thr Phe Val Thr Asp Glu Ser Gly Asp His Thr Gly 
        275                 280                 285             


Trp Lys Ile His Tyr Thr Ser Thr Ala Gln Pro Cys Pro Tyr Pro Met 
    290                 295                 300                 


Ala Pro Pro Asn Gly His Val Ser Pro Val Gln Ala Lys Tyr Ile Leu 
305                 310                 315                 320 


Lys Asp Ser Phe Ser Ile Phe Cys Glu Thr Gly Tyr Glu Leu Leu Gln 
                325                 330                 335     


Gly His Leu Pro Leu Lys Ser Phe Thr Ala Val Cys Gln Lys Asp Gly 
            340                 345                 350         


Ser Trp Asp Arg Pro Met Pro Ala Cys Ser Ile Val Asp Cys Gly Pro 
        355                 360                 365             


Pro Asp Asp Leu Pro Ser Gly Arg Val Glu Tyr Ile Thr Gly Pro Gly 
    370                 375                 380                 


Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr Ser Cys Glu Glu Thr Phe 
385                 390                 395                 400 


Tyr Thr Met Lys Val Asn Asp Gly Lys Tyr Val Cys Glu Ala Asp Gly 
                405                 410                 415     


Phe Trp Thr Ser Ser Lys Gly Glu Lys Ser Leu Pro Val Cys Glu Pro 
            420                 425                 430         


Val Cys Gly Leu Ser Ala Arg Thr Thr Gly Gly Arg Ile Tyr Gly Gly 
        435                 440                 445             


Gln Lys Ala Lys Pro Gly Asp Phe Pro Trp Gln Val Leu Ile Leu Gly 
    450                 455                 460                 


Gly Thr Thr Ala Ala Gly Ala Leu Leu Tyr Asp Asn Trp Val Leu Thr 
465                 470                 475                 480 


Ala Ala His Ala Val Tyr Glu Gln Lys His Asp Ala Ser Ala Leu Asp 
                485                 490                 495     


Ile Arg Met Gly Thr Leu Lys Arg Leu Ser Pro His Tyr Thr Gln Ala 
            500                 505                 510         


Trp Ser Glu Ala Val Phe Ile His Glu Gly Tyr Thr His Asp Ala Gly 
        515                 520                 525             


Phe Asp Asn Asp Ile Ala Leu Ile Lys Leu Asn Asn Lys Val Val Ile 
    530                 535                 540                 


Asn Ser Asn Ile Thr Pro Ile Cys Leu Pro Arg Lys Glu Ala Glu Ser 
545                 550                 555                 560 


Phe Met Arg Thr Asp Asp Ile Gly Thr Ala Ser Gly Trp Gly Leu Thr 
                565                 570                 575     


Gln Arg Gly Phe Leu Ala Arg Asn Leu Met Tyr Val Asp Ile Pro Ile 
            580                 585                 590         


Val Asp His Gln Lys Cys Thr Ala Ala Tyr Glu Lys Pro Pro Tyr Pro 
        595                 600                 605             


Arg Gly Ser Val Thr Ala Asn Met Leu Cys Ala Gly Leu Glu Ser Gly 
    610                 615                 620                 


Gly Lys Asp Ser Cys Arg Gly Asp Ser Gly Gly Ala Leu Val Phe Leu 
625                 630                 635                 640 


Asp Ser Glu Thr Glu Arg Trp Phe Val Gly Gly Ile Val Ser Trp Gly 
                645                 650                 655     


Ser Met Asn Cys Gly Glu Ala Gly Gln Tyr Gly Val Tyr Thr Lys Val 
            660                 665                 670         


Ile Asn Tyr Ile Pro Trp Ile Glu Asn Ile Ile Ser Asp Phe 
        675                 680                 685     


<210>  8326
<211>  185
<212>  PRT
<213>  Homo Sapiens

<400>  8326

Met Arg Leu Leu Thr Leu Leu Gly Leu Leu Cys Gly Ser Val Ala Thr 
1               5                   10                  15      


Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala Ser 
            20                  25                  30          


Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp Thr 
        35                  40                  45              


Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His Phe 
    50                  55                  60                  


Asp Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu Ser 
65                  70                  75                  80  


Ser Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr Asp 
                85                  90                  95      


Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser Ser 
            100                 105                 110         


Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe Thr 
        115                 120                 125             


Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Ile Asp Glu Cys Gln Val 
    130                 135                 140                 


Ala Pro Gly Glu Ala Pro Thr Cys Asp His His Cys His Asn His Leu 
145                 150                 155                 160 


Gly Gly Phe Tyr Cys Ser Cys Arg Ala Gly Tyr Val Leu His Arg Asn 
                165                 170                 175     


Lys Arg Thr Cys Ser Glu Gln Ser Leu 
            180                 185 


<210>  8327
<211>  496
<212>  PRT
<213>  Homo Sapiens

<400>  8327

Met Arg Val Leu Ser Gly Thr Ser Leu Met Leu Cys Ser Leu Leu Leu 
1               5                   10                  15      


Leu Leu Gln Ala Leu Cys Ser Pro Gly Leu Ala Pro Gln Ser Arg Gly 
            20                  25                  30          


His Leu Cys Arg Thr Arg Pro Thr Asp Leu Val Phe Val Val Asp Ser 
        35                  40                  45              


Ser Arg Ser Val Arg Pro Val Glu Phe Glu Lys Val Lys Val Phe Leu 
    50                  55                  60                  


Ser Gln Val Ile Glu Ser Leu Asp Val Gly Pro Asn Ala Thr Arg Val 
65                  70                  75                  80  


Gly Met Val Asn Tyr Ala Ser Thr Val Lys Gln Glu Phe Ser Leu Arg 
                85                  90                  95      


Ala His Val Ser Lys Ala Ala Leu Leu Gln Ala Val Arg Arg Ile Gln 
            100                 105                 110         


Pro Leu Ser Thr Gly Thr Met Thr Gly Leu Ala Ile Gln Phe Ala Ile 
        115                 120                 125             


Thr Lys Ala Phe Gly Asp Ala Glu Gly Gly Arg Ser Arg Ser Pro Asp 
    130                 135                 140                 


Ile Ser Lys Val Val Ile Val Val Thr Asp Gly Arg Pro Gln Asp Ser 
145                 150                 155                 160 


Val Gln Asp Val Ser Ala Arg Ala Arg Ala Ser Gly Val Glu Leu Phe 
                165                 170                 175     


Ala Ile Gly Val Gly Ser Val Asp Lys Ala Thr Leu Arg Gln Ile Ala 
            180                 185                 190         


Ser Glu Pro Gln Asp Glu His Val Asp Tyr Val Glu Ser Tyr Ser Val 
        195                 200                 205             


Ile Glu Lys Leu Ser Arg Lys Phe Gln Glu Ala Phe Cys Val Val Ser 
    210                 215                 220                 


Asp Leu Cys Ala Thr Gly Asp His Asp Cys Glu Gln Val Cys Ile Ser 
225                 230                 235                 240 


Ser Pro Gly Ser Tyr Thr Cys Ala Cys His Glu Gly Phe Thr Leu Asn 
                245                 250                 255     


Ser Asp Gly Lys Thr Cys Asn Val Cys Ser Gly Gly Gly Gly Ser Ser 
            260                 265                 270         


Ala Thr Asp Leu Val Phe Leu Ile Asp Gly Ser Lys Ser Val Arg Pro 
        275                 280                 285             


Glu Asn Phe Glu Leu Val Lys Lys Phe Ile Ser Gln Ile Val Asp Thr 
    290                 295                 300                 


Leu Asp Val Ser Asp Lys Leu Ala Gln Val Gly Leu Val Gln Tyr Ser 
305                 310                 315                 320 


Ser Ser Val Arg Gln Glu Phe Pro Leu Gly Arg Phe His Thr Lys Lys 
                325                 330                 335     


Asp Ile Lys Ala Ala Val Arg Asn Met Ser Tyr Met Glu Lys Gly Thr 
            340                 345                 350         


Met Thr Gly Ala Ala Leu Lys Tyr Leu Ile Asp Asn Ser Phe Thr Val 
        355                 360                 365             


Ser Ser Gly Ala Arg Pro Gly Ala Gln Lys Val Gly Ile Val Phe Thr 
    370                 375                 380                 


Asp Gly Arg Ser Gln Asp Tyr Ile Asn Asp Ala Ala Lys Lys Ala Lys 
385                 390                 395                 400 


Asp Leu Gly Phe Lys Met Phe Ala Val Gly Val Gly Asn Ala Val Glu 
                405                 410                 415     


Asp Glu Leu Arg Glu Ile Ala Ser Glu Pro Val Ala Glu His Tyr Phe 
            420                 425                 430         


Tyr Thr Ala Asp Phe Lys Thr Ile Asn Gln Ile Gly Lys Lys Leu Gln 
        435                 440                 445             


Lys Lys Ile Cys Val Glu Glu Asp Pro Cys Ala Cys Glu Ser Leu Val 
    450                 455                 460                 


Lys Phe Gln Ala Lys Val Glu Gly Leu Leu Gln Ala Leu Thr Arg Lys 
465                 470                 475                 480 


Leu Glu Ala Val Ser Lys Arg Leu Ala Ile Leu Glu Asn Thr Val Val 
                485                 490                 495     


<210>  8328
<211>  115
<212>  PRT
<213>  Homo Sapiens

<400>  8328

Met Glu Asp His Asn Cys Glu Gln Leu Cys Val Asn Val Pro Gly Ser 
1               5                   10                  15      


Phe Val Cys Gln Cys Tyr Ser Gly Tyr Ala Leu Ala Glu Asp Gly Lys 
            20                  25                  30          


Arg Cys Val Ala Val Asp Tyr Cys Ala Ser Glu Asn His Gly Cys Glu 
        35                  40                  45              


His Glu Cys Val Asn Ala Asp Gly Ser Tyr Leu Cys Gln Cys His Glu 
    50                  55                  60                  


Gly Phe Ala Leu Asn Pro Asp Lys Lys Thr Cys Thr Lys Ile Asp Tyr 
65                  70                  75                  80  


Cys Ala Ser Ser Asn His Gly Cys Gln His Glu Cys Val Asn Thr Asp 
                85                  90                  95      


Asp Ser Tyr Ser Cys His Cys Leu Lys Gly Phe Thr Leu Asn Pro Asp 
            100                 105                 110         


Lys Lys Thr 
        115 


<210>  8329
<211>  672
<212>  PRT
<213>  Homo Sapiens

<400>  8329

Met Glu Asp His Asn Cys Glu Gln Leu Cys Val Asn Val Pro Gly Ser 
1               5                   10                  15      


Phe Val Cys Gln Cys Tyr Ser Gly Tyr Ala Leu Ala Glu Asp Gly Lys 
            20                  25                  30          


Arg Cys Val Ala Val Asp Tyr Cys Ala Ser Glu Asn His Gly Cys Glu 
        35                  40                  45              


His Glu Cys Val Asn Ala Asp Gly Ser Tyr Leu Cys Gln Cys His Glu 
    50                  55                  60                  


Gly Phe Ala Leu Asn Pro Asp Lys Lys Thr Cys Thr Lys Ile Asp Tyr 
65                  70                  75                  80  


Cys Ala Ser Ser Asn His Gly Cys Gln His Glu Cys Val Asn Thr Asp 
                85                  90                  95      


Asp Ser Tyr Ser Cys His Cys Leu Lys Gly Phe Thr Leu Asn Pro Asp 
            100                 105                 110         


Lys Lys Thr Cys Arg Arg Ile Asn Tyr Cys Ala Leu Asn Lys Pro Gly 
        115                 120                 125             


Cys Glu His Glu Cys Val Asn Met Glu Glu Ser Tyr Tyr Cys Arg Cys 
    130                 135                 140                 


His Arg Gly Tyr Thr Leu Asp Pro Asn Gly Lys Thr Cys Ser Arg Val 
145                 150                 155                 160 


Asp His Cys Ala Gln Gln Asp His Gly Cys Glu Gln Leu Cys Leu Asn 
                165                 170                 175     


Thr Glu Asp Ser Phe Val Cys Gln Cys Ser Glu Gly Phe Leu Ile Asn 
            180                 185                 190         


Glu Asp Leu Lys Thr Cys Ser Arg Val Asp Tyr Cys Leu Leu Ser Asp 
        195                 200                 205             


His Gly Cys Glu Tyr Ser Cys Val Asn Met Asp Arg Ser Phe Ala Cys 
    210                 215                 220                 


Gln Cys Pro Glu Gly His Val Leu Arg Ser Asp Gly Lys Thr Cys Ala 
225                 230                 235                 240 


Lys Leu Asp Ser Cys Ala Leu Gly Asp His Gly Cys Glu His Ser Cys 
                245                 250                 255     


Val Ser Ser Glu Asp Ser Phe Val Cys Gln Cys Phe Glu Gly Tyr Ile 
            260                 265                 270         


Leu Arg Glu Asp Gly Lys Thr Cys Arg Arg Lys Asp Val Cys Gln Ala 
        275                 280                 285             


Ile Asp His Gly Cys Glu His Ile Cys Val Asn Ser Asp Asp Ser Tyr 
    290                 295                 300                 


Thr Cys Glu Cys Leu Glu Gly Phe Arg Leu Ala Glu Asp Gly Lys Arg 
305                 310                 315                 320 


Cys Arg Arg Lys Asp Val Cys Lys Ser Thr His His Gly Cys Glu His 
                325                 330                 335     


Ile Cys Val Asn Asn Gly Asn Ser Tyr Ile Cys Lys Cys Ser Glu Gly 
            340                 345                 350         


Phe Val Leu Ala Glu Asp Gly Arg Arg Cys Lys Lys Cys Thr Glu Gly 
        355                 360                 365             


Pro Ile Asp Leu Val Phe Val Ile Asp Gly Ser Lys Ser Leu Gly Glu 
    370                 375                 380                 


Glu Asn Phe Glu Val Val Lys Gln Phe Val Thr Gly Ile Ile Asp Ser 
385                 390                 395                 400 


Leu Thr Ile Ser Pro Lys Ala Ala Arg Val Gly Leu Leu Gln Tyr Ser 
                405                 410                 415     


Thr Gln Val His Thr Glu Phe Thr Leu Arg Asn Phe Asn Ser Ala Lys 
            420                 425                 430         


Asp Met Lys Lys Ala Val Ala His Met Lys Tyr Met Gly Lys Gly Ser 
        435                 440                 445             


Met Thr Gly Leu Ala Leu Lys His Met Phe Glu Arg Ser Phe Thr Gln 
    450                 455                 460                 


Gly Glu Gly Ala Arg Pro Leu Ser Thr Arg Val Pro Arg Ala Ala Ile 
465                 470                 475                 480 


Val Phe Thr Asp Gly Arg Ala Gln Asp Asp Val Ser Glu Trp Ala Ser 
                485                 490                 495     


Lys Ala Lys Ala Asn Gly Ile Thr Met Tyr Ala Val Gly Val Gly Lys 
            500                 505                 510         


Ala Ile Glu Glu Glu Leu Gln Glu Ile Ala Ser Glu Pro Thr Asn Lys 
        515                 520                 525             


His Leu Phe Tyr Ala Glu Asp Phe Ser Thr Met Asp Glu Ile Ser Glu 
    530                 535                 540                 


Lys Leu Lys Lys Gly Ile Cys Glu Ala Leu Glu Asp Ser Asp Gly Arg 
545                 550                 555                 560 


Gln Asp Ser Pro Ala Gly Glu Leu Pro Lys Thr Val Gln Gln Pro Thr 
                565                 570                 575     


Glu Ser Glu Pro Val Thr Ile Asn Ile Gln Asp Leu Leu Ser Cys Ser 
            580                 585                 590         


Asn Phe Ala Val Gln His Arg Tyr Leu Phe Glu Glu Asp Asn Leu Leu 
        595                 600                 605             


Arg Ser Thr Gln Lys Leu Ser His Ser Thr Lys Pro Ser Gly Ser Pro 
    610                 615                 620                 


Leu Glu Glu Lys His Asp Gln Cys Lys Cys Glu Asn Leu Ile Met Phe 
625                 630                 635                 640 


Gln Asn Leu Ala Asn Glu Glu Val Arg Lys Leu Thr Gln Arg Leu Glu 
                645                 650                 655     


Glu Met Thr Gln Arg Met Glu Ala Leu Glu Asn Arg Leu Arg Tyr Arg 
            660                 665                 670         


<210>  8330
<211>  956
<212>  PRT
<213>  Homo Sapiens

<400>  8330

Met Glu Lys Met Leu Ala Gly Cys Phe Leu Leu Ile Leu Gly Gln Ile 
1               5                   10                  15      


Val Leu Leu Pro Ala Glu Ala Arg Glu Arg Ser Arg Gly Arg Ser Ile 
            20                  25                  30          


Ser Arg Gly Arg His Ala Arg Thr His Pro Gln Thr Ala Leu Leu Glu 
        35                  40                  45              


Ser Ser Cys Glu Asn Lys Arg Ala Asp Leu Val Phe Ile Ile Asp Ser 
    50                  55                  60                  


Ser Arg Ser Val Asn Thr His Asp Tyr Ala Lys Val Lys Glu Phe Ile 
65                  70                  75                  80  


Val Asp Ile Leu Gln Phe Leu Asp Ile Gly Pro Asp Val Thr Arg Val 
                85                  90                  95      


Gly Leu Leu Gln Tyr Gly Ser Thr Val Lys Asn Glu Phe Ser Leu Lys 
            100                 105                 110         


Thr Phe Lys Arg Lys Ser Glu Val Glu Arg Ala Val Lys Arg Met Arg 
        115                 120                 125             


His Leu Ser Thr Gly Thr Met Thr Gly Leu Ala Ile Gln Tyr Ala Leu 
    130                 135                 140                 


Asn Ile Ala Phe Ser Glu Ala Glu Gly Ala Arg Pro Leu Arg Glu Asn 
145                 150                 155                 160 


Val Pro Arg Val Ile Met Ile Val Thr Asp Gly Arg Pro Gln Asp Ser 
                165                 170                 175     


Val Ala Glu Val Ala Ala Lys Ala Arg Asp Thr Gly Ile Leu Ile Phe 
            180                 185                 190         


Ala Ile Gly Val Gly Gln Val Asp Phe Asn Thr Leu Lys Ser Ile Gly 
        195                 200                 205             


Ser Glu Pro His Glu Asp His Val Phe Leu Val Ala Asn Phe Ser Gln 
    210                 215                 220                 


Ile Glu Thr Leu Thr Ser Val Phe Gln Lys Lys Leu Cys Thr Ala His 
225                 230                 235                 240 


Met Cys Ser Thr Leu Glu His Asn Cys Ala His Phe Cys Ile Asn Ile 
                245                 250                 255     


Pro Gly Ser Tyr Val Cys Arg Cys Lys Gln Gly Tyr Ile Leu Asn Ser 
            260                 265                 270         


Asp Gln Thr Thr Cys Arg Ile Gln Asp Leu Cys Ala Met Glu Asp His 
        275                 280                 285             


Asn Cys Glu Gln Leu Cys Val Asn Val Pro Gly Ser Phe Val Cys Gln 
    290                 295                 300                 


Cys Tyr Ser Gly Tyr Ala Leu Ala Glu Asp Gly Lys Arg Cys Val Ala 
305                 310                 315                 320 


Val Asp Tyr Cys Ala Ser Glu Asn His Gly Cys Glu His Glu Cys Val 
                325                 330                 335     


Asn Ala Asp Gly Ser Tyr Leu Cys Gln Cys His Glu Gly Phe Ala Leu 
            340                 345                 350         


Asn Pro Asp Lys Lys Thr Cys Thr Lys Ile Asp Tyr Cys Ala Ser Ser 
        355                 360                 365             


Asn His Gly Cys Gln His Glu Cys Val Asn Thr Asp Asp Ser Tyr Ser 
    370                 375                 380                 


Cys His Cys Leu Lys Gly Phe Thr Leu Asn Pro Asp Lys Lys Thr Cys 
385                 390                 395                 400 


Arg Arg Ile Asn Tyr Cys Ala Leu Asn Lys Pro Gly Cys Glu His Glu 
                405                 410                 415     


Cys Val Asn Met Glu Glu Ser Tyr Tyr Cys Arg Cys His Arg Gly Tyr 
            420                 425                 430         


Thr Leu Asp Pro Asn Gly Lys Thr Cys Ser Arg Val Asp His Cys Ala 
        435                 440                 445             


Gln Gln Asp His Gly Cys Glu Gln Leu Cys Leu Asn Thr Glu Asp Ser 
    450                 455                 460                 


Phe Val Cys Gln Cys Ser Glu Gly Phe Leu Ile Asn Glu Asp Leu Lys 
465                 470                 475                 480 


Thr Cys Ser Arg Val Asp Tyr Cys Leu Leu Ser Asp His Gly Cys Glu 
                485                 490                 495     


Tyr Ser Cys Val Asn Met Asp Arg Ser Phe Ala Cys Gln Cys Pro Glu 
            500                 505                 510         


Gly His Val Leu Arg Ser Asp Gly Lys Thr Cys Ala Lys Leu Asp Ser 
        515                 520                 525             


Cys Ala Leu Gly Asp His Gly Cys Glu His Ser Cys Val Ser Ser Glu 
    530                 535                 540                 


Asp Ser Phe Val Cys Gln Cys Phe Glu Gly Tyr Ile Leu Arg Glu Asp 
545                 550                 555                 560 


Gly Lys Thr Cys Arg Arg Lys Asp Val Cys Gln Ala Ile Asp His Gly 
                565                 570                 575     


Cys Glu His Ile Cys Val Asn Ser Asp Asp Ser Tyr Thr Cys Glu Cys 
            580                 585                 590         


Leu Glu Gly Phe Arg Leu Ala Glu Asp Gly Lys Arg Cys Arg Arg Lys 
        595                 600                 605             


Asp Val Cys Lys Ser Thr His His Gly Cys Glu His Ile Cys Val Asn 
    610                 615                 620                 


Asn Gly Asn Ser Tyr Ile Cys Lys Cys Ser Glu Gly Phe Val Leu Ala 
625                 630                 635                 640 


Glu Asp Gly Arg Arg Cys Lys Lys Cys Thr Glu Gly Pro Ile Asp Leu 
                645                 650                 655     


Val Phe Val Ile Asp Gly Ser Lys Ser Leu Gly Glu Glu Asn Phe Glu 
            660                 665                 670         


Val Val Lys Gln Phe Val Thr Gly Ile Ile Asp Ser Leu Thr Ile Ser 
        675                 680                 685             


Pro Lys Ala Ala Arg Val Gly Leu Leu Gln Tyr Ser Thr Gln Val His 
    690                 695                 700                 


Thr Glu Phe Thr Leu Arg Asn Phe Asn Ser Ala Lys Asp Met Lys Lys 
705                 710                 715                 720 


Ala Val Ala His Met Lys Tyr Met Gly Lys Gly Ser Met Thr Gly Leu 
                725                 730                 735     


Ala Leu Lys His Met Phe Glu Arg Ser Phe Thr Gln Gly Glu Gly Ala 
            740                 745                 750         


Arg Pro Leu Ser Thr Arg Val Pro Arg Ala Ala Ile Val Phe Thr Asp 
        755                 760                 765             


Gly Arg Ala Gln Asp Asp Val Ser Glu Trp Ala Ser Lys Ala Lys Ala 
    770                 775                 780                 


Asn Gly Ile Thr Met Tyr Ala Val Gly Val Gly Lys Ala Ile Glu Glu 
785                 790                 795                 800 


Glu Leu Gln Glu Ile Ala Ser Glu Pro Thr Asn Lys His Leu Phe Tyr 
                805                 810                 815     


Ala Glu Asp Phe Ser Thr Met Asp Glu Ile Ser Glu Lys Leu Lys Lys 
            820                 825                 830         


Gly Ile Cys Glu Ala Leu Glu Asp Ser Asp Gly Arg Gln Asp Ser Pro 
        835                 840                 845             


Ala Gly Glu Leu Pro Lys Thr Val Gln Gln Pro Thr Glu Ser Glu Pro 
    850                 855                 860                 


Val Thr Ile Asn Ile Gln Asp Leu Leu Ser Cys Ser Asn Phe Ala Val 
865                 870                 875                 880 


Gln His Arg Tyr Leu Phe Glu Glu Asp Asn Leu Leu Arg Ser Thr Gln 
                885                 890                 895     


Lys Leu Ser His Ser Thr Lys Pro Ser Gly Ser Pro Leu Glu Glu Lys 
            900                 905                 910         


His Asp Gln Cys Lys Cys Glu Asn Leu Ile Met Phe Gln Asn Leu Ala 
        915                 920                 925             


Asn Glu Glu Val Arg Lys Leu Thr Gln Arg Leu Glu Glu Met Thr Gln 
    930                 935                 940                 


Arg Met Glu Ala Leu Glu Asn Arg Leu Arg Tyr Arg 
945                 950                 955     


<210>  8331
<211>  915
<212>  PRT
<213>  Homo Sapiens

<400>  8331

Met Glu Lys Met Leu Ala Gly Cys Phe Leu Leu Ile Leu Gly Gln Ile 
1               5                   10                  15      


Val Leu Leu Pro Ala Glu Ala Arg Glu Arg Ser Arg Gly Arg Ser Ile 
            20                  25                  30          


Ser Arg Gly Arg His Ala Arg Thr His Pro Gln Thr Ala Leu Leu Glu 
        35                  40                  45              


Ser Ser Cys Glu Asn Lys Arg Ala Asp Leu Val Phe Ile Ile Asp Ser 
    50                  55                  60                  


Ser Arg Ser Val Asn Thr His Asp Tyr Ala Lys Val Lys Glu Phe Ile 
65                  70                  75                  80  


Val Asp Ile Leu Gln Phe Leu Asp Ile Gly Pro Asp Val Thr Arg Val 
                85                  90                  95      


Gly Leu Leu Gln Tyr Gly Ser Thr Val Lys Asn Glu Phe Ser Leu Lys 
            100                 105                 110         


Thr Phe Lys Arg Lys Ser Glu Val Glu Arg Ala Val Lys Arg Met Arg 
        115                 120                 125             


His Leu Ser Thr Gly Thr Met Thr Gly Leu Ala Ile Gln Tyr Ala Leu 
    130                 135                 140                 


Asn Ile Ala Phe Ser Glu Ala Glu Gly Ala Arg Pro Leu Arg Glu Asn 
145                 150                 155                 160 


Val Pro Arg Val Ile Met Ile Val Thr Asp Gly Arg Pro Gln Asp Ser 
                165                 170                 175     


Val Ala Glu Val Ala Ala Lys Ala Arg Asp Thr Gly Ile Leu Ile Phe 
            180                 185                 190         


Ala Ile Gly Val Gly Gln Val Asp Phe Asn Thr Leu Lys Ser Ile Gly 
        195                 200                 205             


Ser Glu Pro His Glu Asp His Val Phe Leu Val Ala Asn Phe Ser Gln 
    210                 215                 220                 


Ile Glu Thr Leu Thr Ser Val Phe Gln Lys Lys Leu Cys Thr Ala His 
225                 230                 235                 240 


Met Cys Ser Thr Leu Glu His Asn Cys Ala His Phe Cys Ile Asn Ile 
                245                 250                 255     


Pro Gly Ser Tyr Val Cys Arg Cys Lys Gln Gly Tyr Ile Leu Asn Ser 
            260                 265                 270         


Asp Gln Thr Thr Cys Arg Ile Gln Asp Leu Cys Ala Met Glu Asp His 
        275                 280                 285             


Asn Cys Glu Gln Leu Cys Val Asn Val Pro Gly Ser Phe Val Cys Gln 
    290                 295                 300                 


Cys Tyr Ser Gly Tyr Ala Leu Ala Glu Asp Gly Lys Arg Cys Val Ala 
305                 310                 315                 320 


Val Asp Tyr Cys Ala Ser Glu Asn His Gly Cys Glu His Glu Cys Val 
                325                 330                 335     


Asn Ala Asp Gly Ser Tyr Leu Cys Gln Cys His Glu Gly Phe Ala Leu 
            340                 345                 350         


Asn Pro Asp Lys Lys Thr Cys Thr Arg Ile Asn Tyr Cys Ala Leu Asn 
        355                 360                 365             


Lys Pro Gly Cys Glu His Glu Cys Val Asn Met Glu Glu Ser Tyr Tyr 
    370                 375                 380                 


Cys Arg Cys His Arg Gly Tyr Thr Leu Asp Pro Asn Gly Lys Thr Cys 
385                 390                 395                 400 


Ser Arg Val Asp His Cys Ala Gln Gln Asp His Gly Cys Glu Gln Leu 
                405                 410                 415     


Cys Leu Asn Thr Glu Asp Ser Phe Val Cys Gln Cys Ser Glu Gly Phe 
            420                 425                 430         


Leu Ile Asn Glu Asp Leu Lys Thr Cys Ser Arg Val Asp Tyr Cys Leu 
        435                 440                 445             


Leu Ser Asp His Gly Cys Glu Tyr Ser Cys Val Asn Met Asp Arg Ser 
    450                 455                 460                 


Phe Ala Cys Gln Cys Pro Glu Gly His Val Leu Arg Ser Asp Gly Lys 
465                 470                 475                 480 


Thr Cys Ala Lys Leu Asp Ser Cys Ala Leu Gly Asp His Gly Cys Glu 
                485                 490                 495     


His Ser Cys Val Ser Ser Glu Asp Ser Phe Val Cys Gln Cys Phe Glu 
            500                 505                 510         


Gly Tyr Ile Leu Arg Glu Asp Gly Lys Thr Cys Arg Arg Lys Asp Val 
        515                 520                 525             


Cys Gln Ala Ile Asp His Gly Cys Glu His Ile Cys Val Asn Ser Asp 
    530                 535                 540                 


Asp Ser Tyr Thr Cys Glu Cys Leu Glu Gly Phe Arg Leu Ala Glu Asp 
545                 550                 555                 560 


Gly Lys Arg Cys Arg Arg Lys Asp Val Cys Lys Ser Thr His His Gly 
                565                 570                 575     


Cys Glu His Ile Cys Val Asn Asn Gly Asn Ser Tyr Ile Cys Lys Cys 
            580                 585                 590         


Ser Glu Gly Phe Val Leu Ala Glu Asp Gly Arg Arg Cys Lys Lys Cys 
        595                 600                 605             


Thr Glu Gly Pro Ile Asp Leu Val Phe Val Ile Asp Gly Ser Lys Ser 
    610                 615                 620                 


Leu Gly Glu Glu Asn Phe Glu Val Val Lys Gln Phe Val Thr Gly Ile 
625                 630                 635                 640 


Ile Asp Ser Leu Thr Ile Ser Pro Lys Ala Ala Arg Val Gly Leu Leu 
                645                 650                 655     


Gln Tyr Ser Thr Gln Val His Thr Glu Phe Thr Leu Arg Asn Phe Asn 
            660                 665                 670         


Ser Ala Lys Asp Met Lys Lys Ala Val Ala His Met Lys Tyr Met Gly 
        675                 680                 685             


Lys Gly Ser Met Thr Gly Leu Ala Leu Lys His Met Phe Glu Arg Ser 
    690                 695                 700                 


Phe Thr Gln Gly Glu Gly Ala Arg Pro Leu Ser Thr Arg Val Pro Arg 
705                 710                 715                 720 


Ala Ala Ile Val Phe Thr Asp Gly Arg Ala Gln Asp Asp Val Ser Glu 
                725                 730                 735     


Trp Ala Ser Lys Ala Lys Ala Asn Gly Ile Thr Met Tyr Ala Val Gly 
            740                 745                 750         


Val Gly Lys Ala Ile Glu Glu Glu Leu Gln Glu Ile Ala Ser Glu Pro 
        755                 760                 765             


Thr Asn Lys His Leu Phe Tyr Ala Glu Asp Phe Ser Thr Met Asp Glu 
    770                 775                 780                 


Ile Ser Glu Lys Leu Lys Lys Gly Ile Cys Glu Ala Leu Glu Asp Ser 
785                 790                 795                 800 


Asp Gly Arg Gln Asp Ser Pro Ala Gly Glu Leu Pro Lys Thr Val Gln 
                805                 810                 815     


Gln Pro Thr Glu Ser Glu Pro Val Thr Ile Asn Ile Gln Asp Leu Leu 
            820                 825                 830         


Ser Cys Ser Asn Phe Ala Val Gln His Arg Tyr Leu Phe Glu Glu Asp 
        835                 840                 845             


Asn Leu Leu Arg Ser Thr Gln Lys Leu Ser His Ser Thr Lys Pro Ser 
    850                 855                 860                 


Gly Ser Pro Leu Glu Glu Lys His Asp Gln Cys Lys Cys Glu Asn Leu 
865                 870                 875                 880 


Ile Met Phe Gln Asn Leu Ala Asn Glu Glu Val Arg Lys Leu Thr Gln 
                885                 890                 895     


Arg Leu Glu Glu Met Thr Gln Arg Met Glu Ala Leu Glu Asn Arg Leu 
            900                 905                 910         


Arg Tyr Arg 
        915 


<210>  8332
<211>  956
<212>  PRT
<213>  Homo Sapiens

<400>  8332

Met Glu Lys Met Leu Ala Gly Cys Phe Leu Leu Ile Leu Gly Gln Ile 
1               5                   10                  15      


Val Leu Leu Pro Ala Glu Ala Arg Glu Arg Ser Arg Gly Arg Ser Ile 
            20                  25                  30          


Ser Arg Gly Arg His Ala Arg Thr His Pro Gln Thr Ala Leu Leu Glu 
        35                  40                  45              


Ser Ser Cys Glu Asn Lys Arg Ala Asp Leu Val Phe Ile Ile Asp Ser 
    50                  55                  60                  


Ser Arg Ser Val Asn Thr His Asp Tyr Ala Lys Val Lys Glu Phe Ile 
65                  70                  75                  80  


Val Asp Ile Leu Gln Phe Leu Asp Ile Gly Pro Asp Val Thr Arg Val 
                85                  90                  95      


Gly Leu Leu Gln Tyr Gly Ser Thr Val Lys Asn Glu Phe Ser Leu Lys 
            100                 105                 110         


Thr Phe Lys Arg Lys Ser Glu Val Glu Arg Ala Val Lys Arg Met Arg 
        115                 120                 125             


His Leu Ser Thr Gly Thr Met Thr Gly Leu Ala Ile Gln Tyr Ala Leu 
    130                 135                 140                 


Asn Ile Ala Phe Ser Glu Ala Glu Gly Ala Arg Pro Leu Arg Glu Asn 
145                 150                 155                 160 


Val Pro Arg Val Ile Met Ile Val Thr Asp Gly Arg Pro Gln Asp Ser 
                165                 170                 175     


Val Ala Glu Val Ala Ala Lys Ala Arg Asp Thr Gly Ile Leu Ile Phe 
            180                 185                 190         


Ala Ile Gly Val Gly Gln Val Asp Phe Asn Thr Leu Lys Ser Ile Gly 
        195                 200                 205             


Ser Glu Pro His Glu Asp His Val Phe Leu Val Ala Asn Phe Ser Gln 
    210                 215                 220                 


Ile Glu Thr Leu Thr Ser Val Phe Gln Lys Lys Leu Cys Thr Ala His 
225                 230                 235                 240 


Met Cys Ser Thr Leu Glu His Asn Cys Ala His Phe Cys Ile Asn Ile 
                245                 250                 255     


Pro Gly Ser Tyr Val Cys Arg Cys Lys Gln Gly Tyr Ile Leu Asn Ser 
            260                 265                 270         


Asp Gln Thr Thr Cys Arg Ile Gln Asp Leu Cys Ala Met Glu Asp His 
        275                 280                 285             


Asn Cys Glu Gln Leu Cys Val Asn Val Pro Gly Ser Phe Val Cys Gln 
    290                 295                 300                 


Cys Tyr Ser Gly Tyr Ala Leu Ala Glu Asp Gly Lys Arg Cys Val Ala 
305                 310                 315                 320 


Val Asp Tyr Cys Ala Ser Glu Asn His Gly Cys Glu His Glu Cys Val 
                325                 330                 335     


Asn Ala Asp Gly Ser Tyr Leu Cys Gln Cys His Glu Gly Phe Ala Leu 
            340                 345                 350         


Asn Pro Asp Lys Lys Thr Cys Thr Lys Ile Asp Tyr Cys Ala Ser Ser 
        355                 360                 365             


Asn His Gly Cys Gln His Glu Cys Val Asn Thr Asp Asp Ser Tyr Ser 
    370                 375                 380                 


Cys His Cys Leu Lys Gly Phe Thr Leu Asn Pro Asp Lys Lys Thr Cys 
385                 390                 395                 400 


Arg Arg Ile Asn Tyr Cys Ala Leu Asn Lys Pro Gly Cys Glu His Glu 
                405                 410                 415     


Cys Val Asn Met Glu Glu Ser Tyr Tyr Cys Arg Cys His Arg Gly Tyr 
            420                 425                 430         


Thr Leu Asp Pro Asn Gly Lys Thr Cys Ser Arg Val Asp His Cys Ala 
        435                 440                 445             


Gln Gln Asp His Gly Cys Glu Gln Leu Cys Leu Asn Thr Glu Asp Ser 
    450                 455                 460                 


Phe Val Cys Gln Cys Ser Glu Gly Phe Leu Ile Asn Glu Asp Leu Lys 
465                 470                 475                 480 


Thr Cys Ser Arg Val Asp Tyr Cys Leu Leu Ser Asp His Gly Cys Glu 
                485                 490                 495     


Tyr Ser Cys Val Asn Met Asp Arg Ser Phe Ala Cys Gln Cys Pro Glu 
            500                 505                 510         


Gly His Val Leu Arg Ser Asp Gly Lys Thr Cys Ala Lys Leu Asp Ser 
        515                 520                 525             


Cys Ala Leu Gly Asp His Gly Cys Glu His Ser Cys Val Ser Ser Glu 
    530                 535                 540                 


Asp Ser Phe Val Cys Gln Cys Phe Glu Gly Tyr Ile Leu Arg Glu Asp 
545                 550                 555                 560 


Gly Lys Thr Cys Arg Arg Lys Asp Val Cys Gln Ala Ile Asp His Gly 
                565                 570                 575     


Cys Glu His Ile Cys Val Asn Ser Asp Asp Ser Tyr Thr Cys Glu Cys 
            580                 585                 590         


Leu Glu Gly Phe Arg Leu Ala Glu Asp Gly Lys Arg Cys Arg Arg Lys 
        595                 600                 605             


Asp Val Cys Lys Ser Thr His His Gly Cys Glu His Ile Cys Val Asn 
    610                 615                 620                 


Asn Gly Asn Ser Tyr Ile Cys Lys Cys Ser Glu Gly Phe Val Leu Ala 
625                 630                 635                 640 


Glu Asp Gly Arg Arg Cys Lys Lys Cys Thr Glu Gly Pro Ile Asp Leu 
                645                 650                 655     


Val Phe Val Ile Asp Gly Ser Lys Ser Leu Gly Glu Glu Asn Phe Glu 
            660                 665                 670         


Val Val Lys Gln Phe Val Thr Gly Ile Ile Asp Ser Leu Thr Ile Ser 
        675                 680                 685             


Pro Lys Ala Ala Arg Val Gly Leu Leu Gln Tyr Ser Thr Gln Val His 
    690                 695                 700                 


Thr Glu Phe Thr Leu Arg Asn Phe Asn Ser Ala Lys Asp Met Lys Lys 
705                 710                 715                 720 


Ala Val Ala His Met Lys Tyr Met Gly Lys Gly Ser Met Thr Gly Leu 
                725                 730                 735     


Ala Leu Lys His Met Phe Glu Arg Ser Phe Thr Gln Gly Glu Gly Ala 
            740                 745                 750         


Arg Pro Leu Ser Thr Arg Val Pro Arg Ala Ala Ile Val Phe Thr Asp 
        755                 760                 765             


Gly Arg Ala Gln Asp Asp Val Ser Glu Trp Ala Ser Lys Ala Lys Ala 
    770                 775                 780                 


Asn Gly Ile Thr Met Tyr Ala Val Gly Val Gly Lys Ala Ile Glu Glu 
785                 790                 795                 800 


Glu Leu Gln Glu Ile Ala Ser Glu Pro Thr Asn Lys His Leu Phe Tyr 
                805                 810                 815     


Ala Glu Asp Phe Ser Thr Met Asp Glu Ile Ser Glu Lys Leu Lys Lys 
            820                 825                 830         


Gly Ile Cys Glu Ala Leu Glu Asp Ser Asp Gly Arg Gln Asp Ser Pro 
        835                 840                 845             


Ala Gly Glu Leu Pro Lys Thr Val Gln Gln Pro Thr Glu Ser Glu Pro 
    850                 855                 860                 


Val Thr Ile Asn Ile Gln Asp Leu Leu Ser Cys Ser Asn Phe Ala Val 
865                 870                 875                 880 


Gln His Arg Tyr Leu Phe Glu Glu Asp Asn Leu Leu Arg Ser Thr Gln 
                885                 890                 895     


Lys Leu Ser His Ser Thr Lys Pro Ser Gly Ser Pro Leu Glu Glu Lys 
            900                 905                 910         


His Asp Gln Cys Lys Cys Glu Asn Leu Ile Met Phe Gln Asn Leu Ala 
        915                 920                 925             


Asn Glu Glu Val Arg Lys Leu Thr Gln Arg Leu Glu Glu Met Thr Gln 
    930                 935                 940                 


Arg Met Glu Ala Leu Glu Asn Arg Leu Arg Tyr Arg 
945                 950                 955     


<210>  8333
<211>  937
<212>  PRT
<213>  Homo Sapiens

<400>  8333

Met Glu Lys Met Leu Ala Gly Cys Phe Leu Leu Ile Leu Gly Gln Ile 
1               5                   10                  15      


Val Leu Leu Pro Ala Glu Ala Arg Glu Arg Ser Arg Gly Arg Ser Ile 
            20                  25                  30          


Ser Arg Gly Arg His Ala Arg Thr His Pro Gln Thr Ala Leu Leu Glu 
        35                  40                  45              


Ser Ser Cys Glu Asn Lys Arg Ala Asp Leu Val Phe Ile Ile Asp Ser 
    50                  55                  60                  


Ser Arg Ser Val Asn Thr His Asp Tyr Ala Lys Val Lys Glu Phe Ile 
65                  70                  75                  80  


Val Asp Ile Leu Gln Phe Leu Asp Ile Gly Pro Asp Val Thr Arg Val 
                85                  90                  95      


Gly Leu Leu Gln Tyr Gly Ser Thr Val Lys Asn Glu Phe Ser Leu Lys 
            100                 105                 110         


Thr Phe Lys Arg Lys Ser Glu Val Glu Arg Ala Val Lys Arg Met Arg 
        115                 120                 125             


His Leu Ser Thr Gly Thr Met Thr Gly Leu Ala Ile Gln Tyr Ala Leu 
    130                 135                 140                 


Asn Ile Ala Phe Ser Glu Ala Glu Gly Ala Arg Pro Leu Arg Glu Asn 
145                 150                 155                 160 


Val Pro Arg Val Ile Met Ile Val Thr Asp Gly Arg Pro Gln Asp Ser 
                165                 170                 175     


Val Ala Glu Val Ala Ala Lys Ala Arg Asp Thr Gly Ile Leu Ile Phe 
            180                 185                 190         


Ala Ile Gly Val Gly Gln Val Asp Phe Asn Thr Leu Lys Ser Ile Gly 
        195                 200                 205             


Ser Glu Pro His Glu Asp His Val Phe Leu Val Ala Asn Phe Ser Gln 
    210                 215                 220                 


Ile Glu Thr Leu Thr Ser Val Phe Gln Lys Lys Leu Cys Thr Ala His 
225                 230                 235                 240 


Met Cys Ser Thr Leu Glu His Asn Cys Ala His Phe Cys Ile Asn Ile 
                245                 250                 255     


Pro Gly Ser Tyr Val Cys Arg Cys Lys Gln Gly Tyr Ile Leu Asn Ser 
            260                 265                 270         


Asp Gln Thr Thr Cys Arg Ile Gln Asp Leu Cys Ala Met Glu Asp His 
        275                 280                 285             


Asn Cys Glu Gln Leu Cys Val Asn Val Pro Gly Ser Phe Val Cys Gln 
    290                 295                 300                 


Cys Tyr Ser Gly Tyr Ala Leu Ala Glu Asp Gly Lys Arg Cys Val Ala 
305                 310                 315                 320 


Val Asp Tyr Cys Ala Ser Glu Asn His Gly Cys Glu His Glu Cys Val 
                325                 330                 335     


Asn Ala Asp Gly Ser Tyr Leu Cys Gln Cys His Glu Gly Phe Ala Leu 
            340                 345                 350         


Asn Pro Asp Lys Lys Thr Cys Thr Lys Ile Asp Tyr Cys Ala Ser Ser 
        355                 360                 365             


Asn His Gly Cys Gln His Glu Cys Val Asn Thr Asp Asp Ser Tyr Ser 
    370                 375                 380                 


Cys His Cys Leu Lys Gly Phe Thr Leu Asn Pro Asp Lys Lys Thr Cys 
385                 390                 395                 400 


Arg Arg Ile Asn Tyr Cys Ala Leu Asn Lys Pro Gly Cys Glu His Glu 
                405                 410                 415     


Cys Val Asn Met Glu Glu Ser Tyr Tyr Cys Arg Cys His Arg Gly Tyr 
            420                 425                 430         


Thr Leu Asp Pro Asn Gly Lys Thr Cys Ser Arg Val Asp His Cys Ala 
        435                 440                 445             


Gln Gln Asp His Gly Cys Glu Gln Leu Cys Leu Asn Thr Glu Asp Ser 
    450                 455                 460                 


Phe Val Cys Gln Cys Ser Glu Gly Phe Leu Ile Asn Glu Asp Leu Lys 
465                 470                 475                 480 


Thr Cys Ser Arg Val Asp Tyr Cys Leu Leu Ser Asp His Gly Cys Glu 
                485                 490                 495     


Tyr Ser Cys Val Asn Met Asp Arg Ser Phe Ala Cys Gln Cys Pro Glu 
            500                 505                 510         


Gly His Val Leu Arg Ser Asp Gly Lys Thr Cys Ala Lys Leu Asp Ser 
        515                 520                 525             


Cys Ala Leu Gly Asp His Gly Cys Glu His Ser Cys Val Ser Ser Glu 
    530                 535                 540                 


Asp Ser Phe Val Cys Gln Cys Phe Glu Gly Tyr Ile Leu Arg Glu Asp 
545                 550                 555                 560 


Gly Lys Thr Cys Arg Arg Lys Asp Val Cys Gln Ala Ile Asp His Gly 
                565                 570                 575     


Cys Glu His Ile Cys Val Asn Ser Asp Asp Ser Tyr Thr Cys Glu Cys 
            580                 585                 590         


Leu Glu Gly Phe Arg Leu Ala Glu Asp Gly Lys Arg Cys Arg Arg Lys 
        595                 600                 605             


Asp Val Cys Lys Ser Thr His His Gly Cys Glu His Ile Cys Val Asn 
    610                 615                 620                 


Asn Gly Asn Ser Tyr Ile Cys Lys Cys Ser Glu Gly Phe Val Leu Ala 
625                 630                 635                 640 


Glu Asp Gly Arg Arg Cys Lys Lys Cys Thr Glu Gly Pro Ile Asp Leu 
                645                 650                 655     


Val Phe Val Ile Asp Gly Ser Lys Ser Leu Gly Glu Glu Asn Phe Glu 
            660                 665                 670         


Val Val Lys Gln Phe Val Thr Gly Ile Ile Asp Ser Leu Thr Ile Ser 
        675                 680                 685             


Pro Lys Ala Ala Arg Val Gly Leu Leu Gln Tyr Ser Thr Gln Val His 
    690                 695                 700                 


Thr Glu Phe Thr Leu Arg Asn Phe Asn Ser Ala Lys Asp Met Lys Lys 
705                 710                 715                 720 


Ala Val Ala His Met Lys Tyr Met Gly Lys Gly Ser Met Thr Gly Leu 
                725                 730                 735     


Ala Leu Lys His Met Phe Glu Arg Ser Phe Thr Gln Gly Glu Gly Ala 
            740                 745                 750         


Arg Pro Leu Ser Thr Arg Val Pro Arg Ala Ala Ile Val Phe Thr Asp 
        755                 760                 765             


Gly Arg Ala Gln Asp Asp Val Ser Glu Trp Ala Ser Lys Ala Lys Ala 
    770                 775                 780                 


Asn Gly Ile Thr Met Tyr Ala Val Gly Val Gly Lys Ala Ile Glu Glu 
785                 790                 795                 800 


Glu Leu Gln Glu Ile Ala Ser Glu Pro Thr Asn Lys His Leu Phe Tyr 
                805                 810                 815     


Ala Glu Asp Phe Ser Thr Met Asp Glu Ile Ser Glu Lys Leu Lys Lys 
            820                 825                 830         


Gly Ile Cys Glu Ala Leu Glu Asp Ser Asp Gly Arg Gln Asp Ser Pro 
        835                 840                 845             


Ala Gly Glu Leu Pro Lys Thr Val Gln Gln Pro Thr Val Gln His Arg 
    850                 855                 860                 


Tyr Leu Phe Glu Glu Asp Asn Leu Leu Arg Ser Thr Gln Lys Leu Ser 
865                 870                 875                 880 


His Ser Thr Lys Pro Ser Gly Ser Pro Leu Glu Glu Lys His Asp Gln 
                885                 890                 895     


Cys Lys Cys Glu Asn Leu Ile Met Phe Gln Asn Leu Ala Asn Glu Glu 
            900                 905                 910         


Val Arg Lys Leu Thr Gln Arg Leu Glu Glu Met Thr Gln Arg Met Glu 
        915                 920                 925             


Ala Leu Glu Asn Arg Leu Arg Tyr Arg 
    930                 935         


<210>  8334
<211>  195
<212>  PRT
<213>  Homo Sapiens

<400>  8334

Gln Cys Tyr Ser Gly Tyr Ala Leu Ala Glu Asp Gly Lys Arg Cys Val 
1               5                   10                  15      


Ala Val Asp Tyr Cys Ala Ser Glu Asn His Gly Cys Glu His Glu Cys 
            20                  25                  30          


Val Asn Ala Asp Gly Ser Tyr Leu Cys Gln Cys His Glu Gly Phe Ala 
        35                  40                  45              


Leu Asn Pro Asp Lys Lys Thr Cys Thr Lys Ile Asp Tyr Cys Ala Ser 
    50                  55                  60                  


Ser Asn His Gly Cys Gln His Glu Cys Val Asn Thr Asp Asp Ser Tyr 
65                  70                  75                  80  


Ser Cys His Cys Leu Lys Gly Phe Thr Leu Asn Pro Asp Lys Lys Thr 
                85                  90                  95      


Cys Arg Ser Leu Pro Phe Phe Pro Ser Gly Ile Asn Tyr Cys Ala Leu 
            100                 105                 110         


Asn Lys Pro Gly Cys Glu His Glu Cys Val Asn Met Glu Glu Ser Tyr 
        115                 120                 125             


Tyr Cys Arg Cys His Arg Gly Tyr Thr Leu Asp Pro Asn Gly Lys Thr 
    130                 135                 140                 


Cys Ser Arg Val Asp His Cys Ala Gln Gln Asp His Gly Cys Glu Gln 
145                 150                 155                 160 


Leu Cys Leu Asn Thr Glu Asp Ser Phe Val Cys Gln Cys Ser Glu Gly 
                165                 170                 175     


Phe Leu Ile Asn Glu Asp Leu Lys Thr Cys Ser Arg Val Asp Tyr Cys 
            180                 185                 190         


Leu Leu Ser 
        195 


<210>  8335
<211>  720
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8335

Xaa Ala Glu Val Ala Ala Lys Ala Arg Asp Thr Gly Ile Leu Ile Phe 
1               5                   10                  15      


Ala Ile Gly Val Gly Gln Val Asp Phe Asn Thr Leu Lys Ser Ile Gly 
            20                  25                  30          


Ser Glu Pro His Glu Asp His Val Phe Leu Val Ala Asn Phe Ser Gln 
        35                  40                  45              


Ile Glu Thr Leu Thr Ser Val Phe Gln Lys Lys Leu Cys Thr Ala His 
    50                  55                  60                  


Met Cys Ser Thr Leu Glu His Asn Cys Ala His Phe Cys Ile Asn Ile 
65                  70                  75                  80  


Pro Gly Ser Tyr Val Cys Arg Cys Lys Gln Gly Tyr Ile Leu Asn Ser 
                85                  90                  95      


Asp Gln Thr Thr Cys Arg Thr Val Asp Tyr Cys Ala Ser Glu Asn His 
            100                 105                 110         


Gly Cys Glu His Glu Cys Val Asn Ala Asp Gly Ser Tyr Leu Cys Gln 
        115                 120                 125             


Cys His Glu Gly Phe Ala Leu Asn Pro Asp Lys Lys Thr Cys Thr Lys 
    130                 135                 140                 


Ile Asp Tyr Cys Ala Ser Ser Asn His Gly Cys Gln His Glu Cys Val 
145                 150                 155                 160 


Asn Thr Asp Asp Ser Tyr Ser Cys His Cys Leu Lys Gly Phe Thr Leu 
                165                 170                 175     


Asn Pro Asp Lys Lys Thr Cys Arg Arg Ile Asn Tyr Cys Ala Leu Asn 
            180                 185                 190         


Lys Pro Gly Cys Glu His Glu Cys Val Asn Met Glu Glu Ser Tyr Tyr 
        195                 200                 205             


Cys Arg Cys His Arg Gly Tyr Thr Leu Asp Pro Asn Gly Lys Thr Cys 
    210                 215                 220                 


Ser Arg Val Asp His Cys Ala Gln Gln Asp His Gly Cys Glu Gln Leu 
225                 230                 235                 240 


Cys Leu Asn Thr Glu Asp Ser Phe Val Cys Gln Cys Ser Glu Gly Phe 
                245                 250                 255     


Leu Ile Asn Glu Asp Leu Lys Thr Cys Ser Arg Val Asp Tyr Cys Leu 
            260                 265                 270         


Leu Ser Asp His Gly Cys Glu Tyr Ser Cys Val Asn Met Asp Arg Ser 
        275                 280                 285             


Phe Ala Cys Gln Cys Pro Glu Gly His Val Leu Arg Ser Asp Gly Lys 
    290                 295                 300                 


Thr Cys Ala Lys Leu Asp Ser Cys Ala Leu Gly Asp His Gly Cys Glu 
305                 310                 315                 320 


His Ser Cys Val Ser Ser Glu Asp Ser Phe Val Cys Gln Cys Phe Glu 
                325                 330                 335     


Gly Tyr Ile Leu Arg Glu Asp Gly Lys Thr Cys Arg Arg Lys Asp Val 
            340                 345                 350         


Cys Gln Ala Ile Asp His Gly Cys Glu His Ile Cys Val Asn Ser Asp 
        355                 360                 365             


Asp Ser Tyr Thr Cys Glu Cys Leu Glu Gly Phe Arg Leu Ala Glu Asp 
    370                 375                 380                 


Gly Lys Arg Cys Arg Arg Lys Asp Val Cys Lys Ser Thr His His Gly 
385                 390                 395                 400 


Cys Glu His Ile Cys Val Asn Asn Gly Asn Ser Tyr Ile Cys Lys Cys 
                405                 410                 415     


Ser Glu Gly Phe Val Leu Ala Glu Asp Gly Arg Arg Cys Lys Lys Cys 
            420                 425                 430         


Thr Glu Gly Pro Ile Asp Leu Val Phe Val Ile Asp Gly Ser Lys Ser 
        435                 440                 445             


Leu Gly Glu Glu Asn Phe Glu Val Val Lys Gln Phe Val Thr Gly Ile 
    450                 455                 460                 


Ile Asp Ser Leu Thr Ile Ser Pro Lys Ala Ala Arg Val Gly Leu Leu 
465                 470                 475                 480 


Gln Tyr Ser Thr Gln Val His Thr Glu Phe Thr Leu Arg Asn Phe Asn 
                485                 490                 495     


Ser Ala Lys Asp Met Lys Lys Ala Val Ala His Met Lys Tyr Met Gly 
            500                 505                 510         


Lys Gly Ser Met Thr Gly Leu Ala Leu Lys His Met Phe Glu Arg Ser 
        515                 520                 525             


Phe Thr Gln Gly Glu Gly Ala Arg Pro Leu Ser Thr Arg Val Pro Arg 
    530                 535                 540                 


Ala Ala Ile Val Phe Thr Asp Gly Arg Ala Gln Asp Asp Val Ser Glu 
545                 550                 555                 560 


Trp Ala Ser Lys Ala Lys Ala Asn Gly Ile Thr Met Tyr Ala Val Gly 
                565                 570                 575     


Val Gly Lys Ala Ile Glu Glu Glu Leu Gln Glu Ile Ala Ser Glu Pro 
            580                 585                 590         


Thr Asn Lys His Leu Phe Tyr Ala Glu Asp Phe Ser Thr Met Asp Glu 
        595                 600                 605             


Ile Ser Glu Lys Leu Lys Lys Gly Ile Cys Glu Ala Leu Glu Asp Ser 
    610                 615                 620                 


Asp Gly Arg Gln Asp Ser Pro Ala Gly Glu Leu Pro Lys Thr Val Gln 
625                 630                 635                 640 


Gln Pro Thr Val Gln His Arg Tyr Leu Phe Glu Glu Asp Asn Leu Leu 
                645                 650                 655     


Arg Ser Thr Gln Lys Leu Ser His Ser Thr Lys Pro Ser Gly Ser Pro 
            660                 665                 670         


Leu Glu Glu Lys His Asp Gln Cys Lys Cys Glu Asn Leu Ile Met Phe 
        675                 680                 685             


Gln Asn Leu Ala Asn Glu Glu Val Arg Lys Leu Thr Gln Arg Leu Glu 
    690                 695                 700                 


Glu Met Thr Gln Arg Met Glu Ala Leu Glu Asn Arg Leu Arg Tyr Arg 
705                 710                 715                 720 


<210>  8336
<211>  183
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8336

Xaa Asp Ser Cys Ala Leu Gly Asp His Gly Cys Glu His Ser Cys Val 
1               5                   10                  15      


Ser Ser Glu Asp Ser Phe Val Cys Gln Cys Phe Glu Gly Tyr Ile Leu 
            20                  25                  30          


Arg Glu Asp Gly Lys Thr Cys Arg Arg Lys Asp Val Cys Gln Ala Ile 
        35                  40                  45              


Asp His Gly Cys Glu His Ile Cys Val Asn Ser Asp Asp Ser Tyr Thr 
    50                  55                  60                  


Cys Glu Cys Leu Glu Gly Phe Arg Leu Ala Glu Asp Gly Lys Arg Cys 
65                  70                  75                  80  


Arg Lys Cys Thr Glu Gly Pro Ile Asp Leu Val Phe Val Ile Asp Gly 
                85                  90                  95      


Ser Lys Ser Leu Gly Glu Glu Asn Phe Glu Val Val Lys Gln Phe Val 
            100                 105                 110         


Thr Gly Ile Ile Asp Ser Leu Thr Ile Ser Pro Lys Ala Ala Arg Val 
        115                 120                 125             


Gly Leu Leu Gln Tyr Ser Thr Gln Val His Thr Glu Phe Thr Leu Arg 
    130                 135                 140                 


Asn Phe Asn Ser Ala Lys Asp Met Lys Lys Ala Val Ala His Met Lys 
145                 150                 155                 160 


Tyr Met Gly Lys Gly Ser Met Thr Gly Leu Ala Leu Lys His Met Phe 
                165                 170                 175     


Glu Arg Ser Phe Thr Gln Gly 
            180             


<210>  8337
<211>  131
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8337

Xaa Glu Asp Ser Asp Gly Arg Gln Asp Ser Pro Ala Gly Glu Leu Pro 
1               5                   10                  15      


Lys Thr Val Gln Gln Pro Thr Glu Ser Glu Pro Val Thr Ile Asn Ile 
            20                  25                  30          


Gln Asp Leu Leu Ser Cys Ser Asn Phe Ala Val Gln His Arg Tyr Leu 
        35                  40                  45              


Phe Glu Glu Asp Asn Leu Leu Arg Ser Thr Gln Lys Leu Ser His Ser 
    50                  55                  60                  


Thr Lys Pro Ser Gly Ser Pro Leu Glu Glu Lys His Asp Gln Cys Lys 
65                  70                  75                  80  


Cys Glu Asn Leu Ile Met Phe Gln Asn Leu Ala Asn Glu Glu Val Arg 
                85                  90                  95      


Lys Leu Thr Gln Arg Tyr Ile Leu Phe Leu His Tyr Ala Ser Val Trp 
            100                 105                 110         


Asn Ala Lys Asn Ile Ile Lys Thr Ser His Thr Leu Cys Arg Phe Tyr 
        115                 120                 125             


Gln Leu Lys 
    130     


<210>  8338
<211>  176
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8338

Xaa Phe Thr Gln Gly Glu Gly Ala Arg Pro Leu Ser Thr Arg Val Pro 
1               5                   10                  15      


Arg Ala Ala Ile Val Phe Thr Asp Gly Arg Ala Gln Asp Asp Val Ser 
            20                  25                  30          


Glu Trp Ala Ser Lys Ala Lys Ala Asn Gly Ile Thr Met Tyr Ala Val 
        35                  40                  45              


Gly Val Gly Lys Ala Ile Glu Glu Glu Leu Gln Glu Ile Ala Ser Glu 
    50                  55                  60                  


Pro Thr Asn Lys His Leu Phe Tyr Ala Glu Asp Phe Ser Thr Met Asp 
65                  70                  75                  80  


Glu Ile Ser Glu Lys Leu Lys Lys Gly Ile Cys Glu Ala Leu Glu Asp 
                85                  90                  95      


Ser Asp Gly Arg Gln Asp Ser Pro Ala Gly Glu Leu Pro Lys Thr Val 
            100                 105                 110         


Gln Gln Pro Thr Val Gln His Arg Tyr Leu Phe Glu Glu Asp Asn Leu 
        115                 120                 125             


Leu Arg Ser Thr Gln Lys Leu Ser His Ser Thr Lys Pro Ser Gly Ser 
    130                 135                 140                 


Pro Leu Glu Glu Lys His Asp Gln Cys Lys Cys Glu Asn Leu Ile Met 
145                 150                 155                 160 


Phe Gln Asn Leu Ala Asn Glu Glu Gln Arg Ser Ser Leu Ser Ala Leu 
                165                 170                 175     


<210>  8339
<211>  181
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8339

Xaa Ser Ile Gly Ser Glu Pro His Glu Asp His Val Phe Leu Val Ala 
1               5                   10                  15      


Asn Phe Ser Gln Ile Glu Thr Leu Thr Ser Val Phe Gln Lys Lys Leu 
            20                  25                  30          


Cys Ile Gln Asp Leu Cys Ala Met Glu Asp His Asn Cys Glu Gln Leu 
        35                  40                  45              


Cys Val Asn Val Pro Gly Ser Phe Val Cys Gln Cys Tyr Ser Gly Tyr 
    50                  55                  60                  


Ala Leu Ala Glu Asp Gly Lys Arg Cys Val Ala Val Asp Tyr Cys Ala 
65                  70                  75                  80  


Ser Glu Asn His Gly Cys Glu His Glu Cys Val Asn Ala Asp Gly Ser 
                85                  90                  95      


Tyr Leu Cys Gln Cys His Glu Gly Phe Ala Leu Asn Pro Asp Lys Lys 
            100                 105                 110         


Thr Cys Thr Lys Ile Asp Tyr Cys Ala Ser Ser Asn His Gly Cys Gln 
        115                 120                 125             


His Glu Cys Val Asn Thr Asp Asp Ser Tyr Ser Cys His Cys Leu Lys 
    130                 135                 140                 


Gly Phe Thr Leu Asn Pro Asp Lys Lys Thr Cys Arg Arg Ile Asn Tyr 
145                 150                 155                 160 


Cys Ala Leu Asn Lys Pro Gly Cys Glu His Glu Cys Val Asn Met Glu 
                165                 170                 175     


Glu Ser Tyr Tyr Cys 
            180     


<210>  8340
<211>  155
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8340

Xaa Val Asp Tyr Cys Leu Leu Ser Asp His Gly Cys Glu Tyr Ser Cys 
1               5                   10                  15      


Val Asn Met Asp Arg Ser Phe Ala Cys Gln Cys Pro Glu Gly His Val 
            20                  25                  30          


Leu Arg Ser Asp Gly Lys Thr Cys Ala Lys Leu Asp Ser Cys Ala Leu 
        35                  40                  45              


Gly Asp His Gly Cys Glu His Ser Cys Val Ser Ser Glu Asp Ser Phe 
    50                  55                  60                  


Val Cys Gln Cys Phe Glu Gly Tyr Ile Leu Arg Glu Asp Gly Lys Thr 
65                  70                  75                  80  


Cys Arg Arg Lys Asp Val Cys Gln Ala Ile Asp His Gly Cys Glu His 
                85                  90                  95      


Ile Cys Val Asn Ser Asp Asp Ser Tyr Thr Cys Glu Cys Leu Glu Gly 
            100                 105                 110         


Phe Arg Leu Ala Glu Asp Gly Lys Arg Cys Arg Ser Lys Met Ser Ala 
        115                 120                 125             


Asn Gln Pro Thr Met Ala Ala Asn Thr Phe Val Leu Ile Met Gly Ile 
    130                 135                 140                 


Pro Thr Ser Ala Asn Ala Gln Arg Asp Leu Phe 
145                 150                 155 


<210>  8341
<211>  444
<212>  PRT
<213>  Homo Sapiens

<400>  8341

Met Pro Arg Pro Ala Pro Ala Arg Arg Leu Pro Gly Leu Leu Leu Leu 
1               5                   10                  15      


Leu Trp Pro Leu Leu Leu Leu Pro Ser Ala Ala Pro Asp Pro Val Ala 
            20                  25                  30          


Arg Pro Gly Phe Arg Arg Leu Glu Thr Arg Gly Pro Gly Gly Ser Pro 
        35                  40                  45              


Gly Arg Arg Pro Ser Pro Ala Ala Pro Asp Gly Ala Pro Ala Ser Gly 
    50                  55                  60                  


Thr Ser Glu Pro Gly Arg Ala Arg Gly Ala Gly Val Cys Lys Ser Arg 
65                  70                  75                  80  


Pro Leu Asp Leu Val Phe Ile Ile Asp Ser Ser Arg Ser Val Arg Pro 
                85                  90                  95      


Leu Glu Phe Thr Lys Val Lys Thr Phe Val Ser Arg Ile Ile Asp Thr 
            100                 105                 110         


Leu Asp Ile Gly Pro Ala Asp Thr Arg Val Ala Val Val Asn Tyr Ala 
        115                 120                 125             


Ser Thr Val Lys Ile Glu Phe Gln Leu Gln Ala Tyr Thr Asp Lys Gln 
    130                 135                 140                 


Ser Leu Lys Gln Ala Val Gly Arg Ile Thr Pro Leu Ser Thr Gly Thr 
145                 150                 155                 160 


Met Ser Gly Leu Ala Ile Gln Thr Ala Met Asp Glu Ala Phe Thr Val 
                165                 170                 175     


Glu Ala Gly Ala Arg Glu Pro Ser Ser Asn Ile Pro Lys Val Ala Ile 
            180                 185                 190         


Ile Val Thr Asp Gly Arg Pro Gln Asp Gln Val Asn Glu Val Ala Ala 
        195                 200                 205             


Arg Ala Gln Ala Ser Gly Ile Glu Leu Tyr Ala Val Gly Val Asp Arg 
    210                 215                 220                 


Ala Asp Met Ala Ser Leu Lys Met Met Ala Ser Glu Pro Leu Glu Glu 
225                 230                 235                 240 


His Val Phe Tyr Val Glu Thr Tyr Gly Val Ile Glu Lys Leu Ser Ser 
                245                 250                 255     


Arg Phe Gln Glu Thr Phe Cys Ala Leu Asp Arg Cys Ala Leu Asn Thr 
            260                 265                 270         


His Gly Cys Glu His Ile Cys Val Asn Asp Arg Ser Gly Ser Tyr His 
        275                 280                 285             


Cys Glu Cys Tyr Glu Gly Tyr Thr Leu Asn Glu Asp Arg Lys Thr Cys 
    290                 295                 300                 


Ser Ala Gln Asp Lys Cys Ala Leu Gly Thr His Gly Cys Gln His Ile 
305                 310                 315                 320 


Cys Val Asn Asp Arg Thr Gly Ser His His Cys Glu Cys Tyr Glu Gly 
                325                 330                 335     


Tyr Thr Leu Asn Ala Asp Lys Lys Thr Cys Ser Val Arg Asp Lys Cys 
            340                 345                 350         


Ala Leu Gly Ser His Gly Cys Gln His Ile Cys Val Ser Asp Gly Ala 
        355                 360                 365             


Ala Ser Tyr His Cys Asp Cys Tyr Pro Gly Tyr Thr Leu Asn Glu Asp 
    370                 375                 380                 


Lys Lys Thr Cys Ser Ala Thr Glu Glu Ala Arg Arg Leu Val Ser Thr 
385                 390                 395                 400 


Glu Asp Ala Cys Gly Cys Glu Ala Thr Leu Ala Phe Gln Asp Lys Val 
                405                 410                 415     


Ser Ser Tyr Leu Gln Arg Leu Asn Thr Lys Leu Asp Asp Ile Leu Glu 
            420                 425                 430         


Lys Leu Lys Ile Asn Glu Tyr Gly Gln Ile His Arg 
        435                 440                 


<210>  8342
<211>  486
<212>  PRT
<213>  Homo Sapiens

<400>  8342

Met Pro Arg Pro Ala Pro Ala Arg Arg Leu Pro Gly Leu Leu Leu Leu 
1               5                   10                  15      


Leu Trp Pro Leu Leu Leu Leu Pro Ser Ala Ala Pro Asp Pro Val Ala 
            20                  25                  30          


Arg Pro Gly Phe Arg Arg Leu Glu Thr Arg Gly Pro Gly Gly Ser Pro 
        35                  40                  45              


Gly Arg Arg Pro Ser Pro Ala Ala Pro Asp Gly Ala Pro Ala Ser Gly 
    50                  55                  60                  


Thr Ser Glu Pro Gly Arg Ala Arg Gly Ala Gly Val Cys Lys Ser Arg 
65                  70                  75                  80  


Pro Leu Asp Leu Val Phe Ile Ile Asp Ser Ser Arg Ser Val Arg Pro 
                85                  90                  95      


Leu Glu Phe Thr Lys Val Lys Thr Phe Val Ser Arg Ile Ile Asp Thr 
            100                 105                 110         


Leu Asp Ile Gly Pro Ala Asp Thr Arg Val Ala Val Val Asn Tyr Ala 
        115                 120                 125             


Ser Thr Val Lys Ile Glu Phe Gln Leu Gln Ala Tyr Thr Asp Lys Gln 
    130                 135                 140                 


Ser Leu Lys Gln Ala Val Gly Arg Ile Thr Pro Leu Ser Thr Gly Thr 
145                 150                 155                 160 


Met Ser Gly Leu Ala Ile Gln Thr Ala Met Asp Glu Ala Phe Thr Val 
                165                 170                 175     


Glu Ala Gly Ala Arg Glu Pro Ser Ser Asn Ile Pro Lys Val Ala Ile 
            180                 185                 190         


Ile Val Thr Asp Gly Arg Pro Gln Asp Gln Val Asn Glu Val Ala Ala 
        195                 200                 205             


Arg Ala Gln Ala Ser Gly Ile Glu Leu Tyr Ala Val Gly Val Asp Arg 
    210                 215                 220                 


Ala Asp Met Ala Ser Leu Lys Met Met Ala Ser Glu Pro Leu Glu Glu 
225                 230                 235                 240 


His Val Phe Tyr Val Glu Thr Tyr Gly Val Ile Glu Lys Leu Ser Ser 
                245                 250                 255     


Arg Phe Gln Glu Thr Phe Cys Ala Leu Asp Pro Cys Val Leu Gly Thr 
            260                 265                 270         


His Gln Cys Gln His Val Cys Ile Ser Asp Gly Glu Gly Lys His His 
        275                 280                 285             


Cys Glu Cys Ser Gln Gly Tyr Thr Leu Asn Ala Asp Lys Lys Thr Cys 
    290                 295                 300                 


Ser Ala Leu Asp Arg Cys Ala Leu Asn Thr His Gly Cys Glu His Ile 
305                 310                 315                 320 


Cys Val Asn Asp Arg Ser Gly Ser Tyr His Cys Glu Cys Tyr Glu Gly 
                325                 330                 335     


Tyr Thr Leu Asn Glu Asp Arg Lys Thr Cys Ser Ala Gln Asp Lys Cys 
            340                 345                 350         


Ala Leu Gly Thr His Gly Cys Gln His Ile Cys Val Asn Asp Arg Thr 
        355                 360                 365             


Gly Ser His His Cys Glu Cys Tyr Glu Gly Tyr Thr Leu Asn Ala Asp 
    370                 375                 380                 


Lys Lys Thr Cys Ser Val Arg Asp Lys Cys Ala Leu Gly Ser His Gly 
385                 390                 395                 400 


Cys Gln His Ile Cys Val Ser Asp Gly Ala Ala Ser Tyr His Cys Asp 
                405                 410                 415     


Cys Tyr Pro Gly Tyr Thr Leu Asn Glu Asp Lys Lys Thr Cys Ser Ala 
            420                 425                 430         


Thr Glu Glu Ala Arg Arg Leu Val Ser Thr Glu Asp Ala Cys Gly Cys 
        435                 440                 445             


Glu Ala Thr Leu Ala Phe Gln Asp Lys Val Ser Ser Tyr Leu Gln Arg 
    450                 455                 460                 


Leu Asn Thr Lys Leu Asp Asp Ile Leu Glu Lys Leu Lys Ile Asn Glu 
465                 470                 475                 480 


Tyr Gly Gln Ile His Arg 
                485     


<210>  8343
<211>  581
<212>  PRT
<213>  Homo Sapiens

<400>  8343

Met Arg Gly Leu Leu Cys Trp Pro Val Leu Leu Leu Leu Leu Gln Pro 
1               5                   10                  15      


Trp Glu Thr Gln Leu Gln Leu Thr Gly Pro Arg Cys His Thr Gly Pro 
            20                  25                  30          


Leu Asp Leu Val Phe Val Ile Asp Ser Ser Arg Ser Val Arg Pro Phe 
        35                  40                  45              


Glu Phe Glu Thr Met Arg Gln Phe Leu Met Gly Leu Leu Arg Gly Leu 
    50                  55                  60                  


Asn Val Gly Pro Asn Ala Thr Arg Val Gly Val Ile Gln Tyr Ser Ser 
65                  70                  75                  80  


Gln Val Gln Ser Val Phe Pro Leu Arg Ala Phe Ser Arg Arg Glu Asp 
                85                  90                  95      


Met Glu Arg Ala Ile Arg Asp Leu Val Pro Leu Ala Gln Gly Thr Met 
            100                 105                 110         


Thr Gly Leu Ala Ile Gln Tyr Ala Met Asn Val Ala Phe Ser Val Ala 
        115                 120                 125             


Glu Gly Ala Arg Pro Pro Glu Glu Arg Val Pro Arg Val Ala Val Ile 
    130                 135                 140                 


Val Thr Asp Gly Arg Pro Gln Asp Arg Val Ala Glu Val Ala Ala Gln 
145                 150                 155                 160 


Ala Arg Ala Arg Gly Ile Glu Ile Tyr Ala Val Gly Val Gln Arg Ala 
                165                 170                 175     


Asp Val Gly Ser Leu Arg Ala Met Ala Ser Pro Pro Leu Asp Glu His 
            180                 185                 190         


Val Phe Leu Val Glu Ser Phe Asp Leu Ile Gln Glu Phe Gly Leu Gln 
        195                 200                 205             


Phe Gln Ser Arg Leu Cys Ala Ile Asp Leu Cys Ala Glu Gly Thr His 
    210                 215                 220                 


Gly Cys Glu His His Cys Val Asn Ser Pro Gly Ser Tyr Phe Cys His 
225                 230                 235                 240 


Cys Gln Val Gly Phe Val Leu Gln Gln Asp Gln Arg Ser Cys Arg Ala 
                245                 250                 255     


Ile Asp Tyr Cys Ser Phe Gly Asn His Ser Cys Gln His Glu Cys Val 
            260                 265                 270         


Ser Thr Pro Gly Gly Pro Arg Cys His Cys Arg Glu Gly His Asp Leu 
        275                 280                 285             


Gln Pro Asp Gly Arg Ser Cys Gln Val Arg Asp Leu Cys Asn Gly Val 
    290                 295                 300                 


Asp His Gly Cys Glu Phe Gln Cys Val Ser Glu Gly Leu Ser Tyr Arg 
305                 310                 315                 320 


Cys Leu Cys Pro Glu Gly Arg Gln Leu Gln Ala Asp Gly Lys Ser Cys 
                325                 330                 335     


Asn Arg Cys Arg Glu Gly His Val Asp Leu Val Leu Leu Val Asp Gly 
            340                 345                 350         


Ser Lys Ser Val Arg Pro Gln Asn Phe Glu Leu Val Lys Arg Phe Val 
        355                 360                 365             


Asn Gln Ile Val Asp Phe Leu Asp Val Ser Pro Glu Gly Thr Arg Val 
    370                 375                 380                 


Gly Leu Val Gln Phe Ser Ser Arg Val Arg Thr Glu Phe Pro Leu Gly 
385                 390                 395                 400 


Arg Tyr Gly Thr Ala Ala Glu Val Lys Gln Ala Val Leu Ala Val Glu 
                405                 410                 415     


Tyr Met Glu Arg Gly Thr Met Thr Gly Leu Ala Leu Arg His Met Val 
            420                 425                 430         


Glu His Ser Phe Ser Glu Ala Gln Gly Ala Arg Pro Arg Ala Leu Asn 
        435                 440                 445             


Val Pro Arg Val Gly Leu Val Phe Thr Asp Gly Arg Ser Gln Asp Asp 
    450                 455                 460                 


Ile Ser Val Trp Ala Ala Arg Ala Lys Glu Glu Gly Ile Val Met Tyr 
465                 470                 475                 480 


Ala Val Gly Val Gly Lys Ala Val Glu Ala Glu Leu Arg Glu Ile Ala 
                485                 490                 495     


Ser Glu Pro Ala Glu Leu His Val Ser Tyr Ala Pro Asp Phe Gly Thr 
            500                 505                 510         


Met Thr His Leu Leu Glu Asn Leu Arg Gly Ser Ile Cys Pro Glu Glu 
        515                 520                 525             


Gly Ile Ser Ala Gly Thr Glu Leu Arg Ser Pro Cys Glu Cys Glu Ser 
    530                 535                 540                 


Leu Val Glu Phe Gln Gly Arg Thr Leu Gly Ala Leu Glu Ser Leu Thr 
545                 550                 555                 560 


Leu Asn Leu Ala Gln Leu Thr Ala Arg Leu Glu Asp Leu Glu Asn Gln 
                565                 570                 575     


Leu Ala Asn Gln Lys 
            580     


<210>  8344
<211>  581
<212>  PRT
<213>  Homo Sapiens

<400>  8344

Met Arg Gly Leu Leu Cys Trp Pro Val Leu Leu Leu Leu Leu Gln Pro 
1               5                   10                  15      


Trp Glu Thr Gln Leu Gln Leu Thr Gly Pro Arg Cys His Thr Gly Pro 
            20                  25                  30          


Leu Asp Leu Val Phe Val Ile Asp Ser Ser Arg Ser Val Arg Pro Phe 
        35                  40                  45              


Glu Phe Glu Thr Met Arg Gln Phe Leu Met Gly Leu Leu Arg Gly Leu 
    50                  55                  60                  


Asn Val Gly Pro Asn Ala Thr Arg Val Gly Val Ile Gln Tyr Ser Ser 
65                  70                  75                  80  


Gln Val Gln Ser Val Phe Pro Leu Arg Ala Phe Ser Arg Arg Glu Asp 
                85                  90                  95      


Met Glu Arg Ala Ile Arg Asp Leu Val Pro Leu Ala Gln Gly Thr Met 
            100                 105                 110         


Thr Gly Leu Ala Ile Gln Tyr Ala Met Asn Val Ala Phe Ser Val Ala 
        115                 120                 125             


Glu Gly Ala Arg Pro Pro Glu Glu Arg Val Pro Arg Val Ala Val Ile 
    130                 135                 140                 


Val Thr Asp Gly Arg Pro Gln Asp Arg Val Ala Glu Val Ala Ala Gln 
145                 150                 155                 160 


Ala Arg Ala Arg Gly Ile Glu Ile Tyr Ala Val Gly Val Gln Arg Ala 
                165                 170                 175     


Asp Val Gly Ser Leu Arg Ala Met Ala Ser Pro Pro Leu Asp Glu His 
            180                 185                 190         


Val Phe Leu Val Glu Ser Phe Asp Leu Ile Gln Glu Phe Gly Leu Gln 
        195                 200                 205             


Phe Gln Ser Arg Leu Cys Ala Ile Asp Leu Cys Ala Glu Gly Thr His 
    210                 215                 220                 


Gly Cys Glu His His Cys Val Asn Ser Pro Gly Ser Tyr Phe Cys His 
225                 230                 235                 240 


Cys Gln Val Gly Phe Val Leu Gln Gln Asp Gln Arg Ser Cys Arg Ala 
                245                 250                 255     


Ile Asp Tyr Cys Ser Phe Gly Asn His Ser Cys Gln His Glu Cys Val 
            260                 265                 270         


Ser Thr Pro Gly Gly Pro Arg Cys His Cys Arg Glu Gly His Asp Leu 
        275                 280                 285             


Gln Pro Asp Gly Arg Ser Cys Gln Val Arg Asp Leu Cys Asn Gly Val 
    290                 295                 300                 


Asp His Gly Cys Glu Phe Gln Cys Val Ser Glu Gly Leu Ser Tyr Arg 
305                 310                 315                 320 


Cys Leu Cys Pro Glu Gly Arg Gln Leu Gln Ala Asp Gly Lys Ser Cys 
                325                 330                 335     


Asn Arg Cys Arg Glu Gly His Val Asp Leu Val Leu Leu Val Asp Gly 
            340                 345                 350         


Ser Lys Ser Val Arg Pro Gln Asn Phe Glu Leu Val Lys Arg Phe Val 
        355                 360                 365             


Asn Gln Ile Val Asp Phe Leu Asp Val Ser Pro Glu Gly Thr Arg Val 
    370                 375                 380                 


Gly Leu Val Gln Phe Ser Ser Arg Val Arg Thr Glu Phe Pro Leu Gly 
385                 390                 395                 400 


Arg Tyr Gly Thr Ala Ala Glu Val Lys Gln Ala Val Leu Ala Val Glu 
                405                 410                 415     


Tyr Met Glu Arg Gly Thr Met Thr Gly Leu Ala Leu Arg His Met Val 
            420                 425                 430         


Glu His Ser Phe Ser Glu Ala Gln Gly Ala Arg Pro Arg Ala Leu Asn 
        435                 440                 445             


Val Pro Arg Val Gly Leu Val Phe Thr Asp Gly Arg Ser Gln Asp Asp 
    450                 455                 460                 


Ile Ser Val Trp Ala Ala Arg Ala Lys Glu Glu Gly Ile Val Met Tyr 
465                 470                 475                 480 


Ala Val Gly Val Gly Lys Ala Val Glu Ala Glu Leu Arg Glu Ile Ala 
                485                 490                 495     


Ser Glu Pro Ala Glu Leu His Val Ser Tyr Ala Pro Asp Phe Gly Thr 
            500                 505                 510         


Met Thr His Leu Leu Glu Asn Leu Arg Gly Ser Ile Cys Pro Glu Glu 
        515                 520                 525             


Gly Ile Ser Ala Gly Thr Glu Leu Arg Ser Pro Cys Glu Cys Glu Ser 
    530                 535                 540                 


Leu Val Glu Phe Gln Gly Arg Thr Leu Gly Ala Leu Glu Ser Leu Thr 
545                 550                 555                 560 


Leu Asn Leu Ala Gln Leu Thr Ala Arg Leu Glu Asp Leu Glu Asn Gln 
                565                 570                 575     


Leu Ala Asn Gln Lys 
            580     


<210>  8345
<211>  540
<212>  PRT
<213>  Homo Sapiens

<400>  8345

Met Arg Gly Leu Leu Cys Trp Pro Val Leu Leu Leu Leu Leu Gln Pro 
1               5                   10                  15      


Trp Glu Thr Gln Leu Gln Leu Thr Gly Pro Arg Cys His Thr Gly Pro 
            20                  25                  30          


Leu Asp Leu Val Phe Val Ile Asp Ser Ser Arg Ser Val Arg Pro Phe 
        35                  40                  45              


Glu Phe Glu Thr Met Arg Gln Phe Leu Met Gly Leu Leu Arg Gly Leu 
    50                  55                  60                  


Asn Val Gly Pro Asn Ala Thr Arg Val Gly Val Ile Gln Tyr Ser Ser 
65                  70                  75                  80  


Gln Val Gln Ser Val Phe Pro Leu Arg Ala Phe Ser Arg Arg Glu Asp 
                85                  90                  95      


Met Glu Arg Ala Ile Arg Asp Leu Val Pro Leu Ala Gln Gly Thr Met 
            100                 105                 110         


Thr Gly Leu Ala Ile Gln Tyr Ala Met Asn Val Ala Phe Ser Val Ala 
        115                 120                 125             


Glu Gly Ala Arg Pro Pro Glu Glu Arg Val Pro Arg Val Ala Val Ile 
    130                 135                 140                 


Val Thr Asp Gly Arg Pro Gln Asp Arg Val Ala Glu Val Ala Ala Gln 
145                 150                 155                 160 


Ala Arg Ala Arg Gly Ile Glu Ile Tyr Ala Val Gly Val Gln Arg Ala 
                165                 170                 175     


Asp Val Gly Ser Leu Arg Ala Met Ala Ser Pro Pro Leu Asp Glu His 
            180                 185                 190         


Val Phe Leu Val Glu Ser Phe Asp Leu Ile Gln Glu Phe Gly Leu Gln 
        195                 200                 205             


Phe Gln Ser Arg Leu Cys Ala Ile Asp Tyr Cys Ser Phe Gly Asn His 
    210                 215                 220                 


Ser Cys Gln His Glu Cys Val Ser Thr Pro Gly Gly Pro Arg Cys His 
225                 230                 235                 240 


Cys Arg Glu Gly His Asp Leu Gln Pro Asp Gly Arg Ser Cys Gln Val 
                245                 250                 255     


Arg Asp Leu Cys Asn Gly Val Asp His Gly Cys Glu Phe Gln Cys Val 
            260                 265                 270         


Ser Glu Gly Leu Ser Tyr Arg Cys Leu Cys Pro Glu Gly Arg Gln Leu 
        275                 280                 285             


Gln Ala Asp Gly Lys Ser Cys Asn Arg Cys Arg Glu Gly His Val Asp 
    290                 295                 300                 


Leu Val Leu Leu Val Asp Gly Ser Lys Ser Val Arg Pro Gln Asn Phe 
305                 310                 315                 320 


Glu Leu Val Lys Arg Phe Val Asn Gln Ile Val Asp Phe Leu Asp Val 
                325                 330                 335     


Ser Pro Glu Gly Thr Arg Val Gly Leu Val Gln Phe Ser Ser Arg Val 
            340                 345                 350         


Arg Thr Glu Phe Pro Leu Gly Arg Tyr Gly Thr Ala Ala Glu Val Lys 
        355                 360                 365             


Gln Ala Val Leu Ala Val Glu Tyr Met Glu Arg Gly Thr Met Thr Gly 
    370                 375                 380                 


Leu Ala Leu Arg His Met Val Glu His Ser Phe Ser Glu Ala Gln Gly 
385                 390                 395                 400 


Ala Arg Pro Arg Ala Leu Asn Val Pro Arg Val Gly Leu Val Phe Thr 
                405                 410                 415     


Asp Gly Arg Ser Gln Asp Asp Ile Ser Val Trp Ala Ala Arg Ala Lys 
            420                 425                 430         


Glu Glu Gly Ile Val Met Tyr Ala Val Gly Val Gly Lys Ala Val Glu 
        435                 440                 445             


Ala Glu Leu Arg Glu Ile Ala Ser Glu Pro Ala Glu Leu His Val Ser 
    450                 455                 460                 


Tyr Ala Pro Asp Phe Gly Thr Met Thr His Leu Leu Glu Asn Leu Arg 
465                 470                 475                 480 


Gly Ser Ile Cys Pro Glu Glu Gly Ile Ser Ala Gly Thr Glu Leu Arg 
                485                 490                 495     


Ser Pro Cys Glu Cys Glu Ser Leu Val Glu Phe Gln Gly Arg Thr Leu 
            500                 505                 510         


Gly Ala Leu Glu Ser Leu Thr Leu Asn Leu Ala Gln Leu Thr Ala Arg 
        515                 520                 525             


Leu Glu Asp Leu Glu Asn Gln Leu Ala Asn Gln Lys 
    530                 535                 540 


<210>  8346
<211>  622
<212>  PRT
<213>  Homo Sapiens

<400>  8346

Met Arg Gly Leu Leu Cys Trp Pro Val Leu Leu Leu Leu Leu Gln Pro 
1               5                   10                  15      


Trp Glu Thr Gln Leu Gln Leu Thr Gly Pro Arg Cys His Thr Gly Pro 
            20                  25                  30          


Leu Asp Leu Val Phe Val Ile Asp Ser Ser Arg Ser Val Arg Pro Phe 
        35                  40                  45              


Glu Phe Glu Thr Met Arg Gln Phe Leu Met Gly Leu Leu Arg Gly Leu 
    50                  55                  60                  


Asn Val Gly Pro Asn Ala Thr Arg Val Gly Val Ile Gln Tyr Ser Ser 
65                  70                  75                  80  


Gln Val Gln Ser Val Phe Pro Leu Arg Ala Phe Ser Arg Arg Glu Asp 
                85                  90                  95      


Met Glu Arg Ala Ile Arg Asp Leu Val Pro Leu Ala Gln Gly Thr Met 
            100                 105                 110         


Thr Gly Leu Ala Ile Gln Tyr Ala Met Asn Val Ala Phe Ser Val Ala 
        115                 120                 125             


Glu Gly Ala Arg Pro Pro Glu Glu Arg Val Pro Arg Val Ala Val Ile 
    130                 135                 140                 


Val Thr Asp Gly Arg Pro Gln Asp Arg Val Ala Glu Val Ala Ala Gln 
145                 150                 155                 160 


Ala Arg Ala Arg Gly Ile Glu Ile Tyr Ala Val Gly Val Gln Arg Ala 
                165                 170                 175     


Asp Val Gly Ser Leu Arg Ala Met Ala Ser Pro Pro Leu Asp Glu His 
            180                 185                 190         


Val Phe Leu Val Glu Ser Phe Asp Leu Ile Gln Glu Phe Gly Leu Gln 
        195                 200                 205             


Phe Gln Ser Arg Leu Cys Gly Lys Asp Gln Cys Ala Glu Gly Gly His 
    210                 215                 220                 


Gly Cys Gln His Gln Cys Val Asn Ala Trp Ala Met Phe His Cys Thr 
225                 230                 235                 240 


Cys Asn Pro Gly Tyr Lys Leu Ala Ala Asp Asn Lys Ser Cys Leu Ala 
                245                 250                 255     


Ile Asp Leu Cys Ala Glu Gly Thr His Gly Cys Glu His His Cys Val 
            260                 265                 270         


Asn Ser Pro Gly Ser Tyr Phe Cys His Cys Gln Val Gly Phe Val Leu 
        275                 280                 285             


Gln Gln Asp Gln Arg Ser Cys Arg Ala Ile Asp Tyr Cys Ser Phe Gly 
    290                 295                 300                 


Asn His Ser Cys Gln His Glu Cys Val Ser Thr Pro Gly Gly Pro Arg 
305                 310                 315                 320 


Cys His Cys Arg Glu Gly His Asp Leu Gln Pro Asp Gly Arg Ser Cys 
                325                 330                 335     


Gln Val Arg Asp Leu Cys Asn Gly Val Asp His Gly Cys Glu Phe Gln 
            340                 345                 350         


Cys Val Ser Glu Gly Leu Ser Tyr Arg Cys Leu Cys Pro Glu Gly Arg 
        355                 360                 365             


Gln Leu Gln Ala Asp Gly Lys Ser Cys Asn Arg Cys Arg Glu Gly His 
    370                 375                 380                 


Val Asp Leu Val Leu Leu Val Asp Gly Ser Lys Ser Val Arg Pro Gln 
385                 390                 395                 400 


Asn Phe Glu Leu Val Lys Arg Phe Val Asn Gln Ile Val Asp Phe Leu 
                405                 410                 415     


Asp Val Ser Pro Glu Gly Thr Arg Val Gly Leu Val Gln Phe Ser Ser 
            420                 425                 430         


Arg Val Arg Thr Glu Phe Pro Leu Gly Arg Tyr Gly Thr Ala Ala Glu 
        435                 440                 445             


Val Lys Gln Ala Val Leu Ala Val Glu Tyr Met Glu Arg Gly Thr Met 
    450                 455                 460                 


Thr Gly Leu Ala Leu Arg His Met Val Glu His Ser Phe Ser Glu Ala 
465                 470                 475                 480 


Gln Gly Ala Arg Pro Arg Ala Leu Asn Val Pro Arg Val Gly Leu Val 
                485                 490                 495     


Phe Thr Asp Gly Arg Ser Gln Asp Asp Ile Ser Val Trp Ala Ala Arg 
            500                 505                 510         


Ala Lys Glu Glu Gly Ile Val Met Tyr Ala Val Gly Val Gly Lys Ala 
        515                 520                 525             


Val Glu Ala Glu Leu Arg Glu Ile Ala Ser Glu Pro Ala Glu Leu His 
    530                 535                 540                 


Val Ser Tyr Ala Pro Asp Phe Gly Thr Met Thr His Leu Leu Glu Asn 
545                 550                 555                 560 


Leu Arg Gly Ser Ile Cys Pro Glu Glu Gly Ile Ser Ala Gly Thr Glu 
                565                 570                 575     


Leu Arg Ser Pro Cys Glu Cys Glu Ser Leu Val Glu Phe Gln Gly Arg 
            580                 585                 590         


Thr Leu Gly Ala Leu Glu Ser Leu Thr Leu Asn Leu Ala Gln Leu Thr 
        595                 600                 605             


Ala Arg Leu Glu Asp Leu Glu Asn Gln Leu Ala Asn Gln Lys 
    610                 615                 620         


<210>  8347
<211>  499
<212>  PRT
<213>  Homo Sapiens

<400>  8347

Met Arg Gly Leu Leu Cys Trp Pro Val Leu Leu Leu Leu Leu Gln Pro 
1               5                   10                  15      


Trp Glu Thr Gln Leu Gln Leu Thr Gly Pro Arg Cys His Thr Gly Pro 
            20                  25                  30          


Leu Asp Leu Val Phe Val Ile Asp Ser Ser Arg Ser Val Arg Pro Phe 
        35                  40                  45              


Glu Phe Glu Thr Met Arg Gln Phe Leu Met Gly Leu Leu Arg Gly Leu 
    50                  55                  60                  


Asn Val Gly Pro Asn Ala Thr Arg Val Gly Val Ile Gln Tyr Ser Ser 
65                  70                  75                  80  


Gln Val Gln Ser Val Phe Pro Leu Arg Ala Phe Ser Arg Arg Glu Asp 
                85                  90                  95      


Met Glu Arg Ala Ile Arg Asp Leu Val Pro Leu Ala Gln Gly Thr Met 
            100                 105                 110         


Thr Gly Leu Ala Ile Gln Tyr Ala Met Asn Val Ala Phe Ser Val Ala 
        115                 120                 125             


Glu Gly Ala Arg Pro Pro Glu Glu Arg Val Pro Arg Val Ala Val Ile 
    130                 135                 140                 


Val Thr Asp Gly Arg Pro Gln Asp Arg Val Ala Glu Val Ala Ala Gln 
145                 150                 155                 160 


Ala Arg Ala Arg Gly Ile Glu Ile Tyr Ala Val Gly Val Gln Arg Ala 
                165                 170                 175     


Asp Val Gly Ser Leu Arg Ala Met Ala Ser Pro Pro Leu Asp Glu His 
            180                 185                 190         


Val Phe Leu Val Glu Ser Phe Asp Leu Ile Gln Glu Phe Gly Leu Gln 
        195                 200                 205             


Phe Gln Ser Arg Leu Cys Val Arg Asp Leu Cys Asn Gly Val Asp His 
    210                 215                 220                 


Gly Cys Glu Phe Gln Cys Val Ser Glu Gly Leu Ser Tyr Arg Cys Leu 
225                 230                 235                 240 


Cys Pro Glu Gly Arg Gln Leu Gln Ala Asp Gly Lys Ser Cys Asn Arg 
                245                 250                 255     


Cys Arg Glu Gly His Val Asp Leu Val Leu Leu Val Asp Gly Ser Lys 
            260                 265                 270         


Ser Val Arg Pro Gln Asn Phe Glu Leu Val Lys Arg Phe Val Asn Gln 
        275                 280                 285             


Ile Val Asp Phe Leu Asp Val Ser Pro Glu Gly Thr Arg Val Gly Leu 
    290                 295                 300                 


Val Gln Phe Ser Ser Arg Val Arg Thr Glu Phe Pro Leu Gly Arg Tyr 
305                 310                 315                 320 


Gly Thr Ala Ala Glu Val Lys Gln Ala Val Leu Ala Val Glu Tyr Met 
                325                 330                 335     


Glu Arg Gly Thr Met Thr Gly Leu Ala Leu Arg His Met Val Glu His 
            340                 345                 350         


Ser Phe Ser Glu Ala Gln Gly Ala Arg Pro Arg Ala Leu Asn Val Pro 
        355                 360                 365             


Arg Val Gly Leu Val Phe Thr Asp Gly Arg Ser Gln Asp Asp Ile Ser 
    370                 375                 380                 


Val Trp Ala Ala Arg Ala Lys Glu Glu Gly Ile Val Met Tyr Ala Val 
385                 390                 395                 400 


Gly Val Gly Lys Ala Val Glu Ala Glu Leu Arg Glu Ile Ala Ser Glu 
                405                 410                 415     


Pro Ala Glu Leu His Val Ser Tyr Ala Pro Asp Phe Gly Thr Met Thr 
            420                 425                 430         


His Leu Leu Glu Asn Leu Arg Gly Ser Ile Cys Pro Glu Glu Gly Ile 
        435                 440                 445             


Ser Ala Gly Thr Glu Leu Arg Ser Pro Cys Glu Cys Glu Ser Leu Val 
    450                 455                 460                 


Glu Phe Gln Gly Arg Thr Leu Gly Ala Leu Glu Ser Leu Thr Leu Asn 
465                 470                 475                 480 


Leu Ala Gln Leu Thr Ala Arg Leu Glu Asp Leu Glu Asn Gln Leu Ala 
                485                 490                 495     


Asn Gln Lys 
            


<210>  8348
<211>  121
<212>  PRT
<213>  Homo Sapiens

<400>  8348

Met Asp Phe Gln Arg Gly Lys Asn Leu Arg Tyr Gln Leu Leu Gln Leu 
1               5                   10                  15      


Val Glu Pro Phe Gly Val Ile Ser Asn His Leu Ile Leu Asn Lys Ile 
            20                  25                  30          


Asn Glu Ala Phe Ile Glu Met Ala Thr Thr Glu Asp Ala Gln Ala Ala 
        35                  40                  45              


Val Asp Tyr Tyr Thr Thr Thr Pro Ala Leu Val Phe Gly Lys Pro Val 
    50                  55                  60                  


Arg Val His Leu Ser Gln Lys Tyr Lys Arg Ile Lys Lys Pro Glu Gly 
65                  70                  75                  80  


Lys Pro Asp Gln Lys Phe Asp Gln Lys Gln Glu Leu Gly Arg Val Ile 
                85                  90                  95      


His Leu Ser Asn Leu Pro His Ser Gly Tyr Ser Asp Ser Ala Val Leu 
            100                 105                 110         


Lys Leu Ala Glu Pro Tyr Gly Lys Ile 
        115                 120     


<210>  8349
<211>  6
<212>  PRT
<213>  Homo Sapiens

<400>  8349

Met Gly Asp Pro Phe Met 
1               5       


<210>  8350
<211>  25
<212>  PRT
<213>  Homo Sapiens

<400>  8350

Met Gly Asp Pro Phe Met Leu Gln Gln Ser Thr Asn Pro Ala Pro Gly 
1               5                   10                  15      


Ile Leu Gly Pro Pro Pro Pro Ser Phe 
            20                  25  


<210>  8351
<211>  81
<212>  PRT
<213>  Homo Sapiens

<400>  8351

Met Gly Asp Pro Phe Met Leu Gln Gln Ser Thr Asn Pro Ala Pro Gly 
1               5                   10                  15      


Ile Leu Gly Pro Pro Pro Pro Ser Phe His Leu Gly Gly Pro Ala Val 
            20                  25                  30          


Gly Pro Arg Gly Asn Leu Gly Ala Gly Asn Gly Asn Leu Gln Gly Pro 
        35                  40                  45              


Arg His Met Gln Lys Gly Arg Val Glu Thr Ser Arg Val Val His Ile 
    50                  55                  60                  


Met Asp Phe Gln Arg Gly Lys Asn Leu Arg Tyr Gln Leu Leu Gln Leu 
65                  70                  75                  80  


Val 
    


<210>  8352
<211>  86
<212>  PRT
<213>  Homo Sapiens

<400>  8352

Met Gly Asp Pro Phe Met Leu Gln Gln Ser Thr Asn Pro Ala Pro Gly 
1               5                   10                  15      


Ile Leu Gly Pro Pro Pro Pro Ser Phe His Leu Gly Gly Pro Ala Val 
            20                  25                  30          


Gly Pro Arg Gly Asn Leu Gly Ala Gly Asn Gly Asn Leu Gln Gly Pro 
        35                  40                  45              


Arg His Met Gln Lys Gly Arg Val Glu Thr Ser Arg Val Val His Ile 
    50                  55                  60                  


Met Asp Phe Gln Arg Gly Lys Asn Leu Arg Tyr Gln Leu Leu Gln Leu 
65                  70                  75                  80  


Val Glu Pro Phe Gly Val 
                85      


<210>  8353
<211>  109
<212>  PRT
<213>  Homo Sapiens

<400>  8353

Met Gly Asp Pro Phe Met Leu Gln Gln Ser Thr Asn Pro Ala Pro Gly 
1               5                   10                  15      


Ile Leu Gly Pro Pro Pro Pro Ser Phe His Leu Gly Gly Pro Ala Val 
            20                  25                  30          


Gly Pro Arg Gly Asn Leu Gly Ala Gly Asn Gly Asn Leu Gln Gly Pro 
        35                  40                  45              


Arg His Met Gln Lys Gly Arg Val Glu Thr Ser Arg Val Val His Ile 
    50                  55                  60                  


Met Asp Phe Gln Arg Gly Lys Asn Leu Arg Tyr Gln Leu Leu Gln Leu 
65                  70                  75                  80  


Val Glu Pro Phe Gly Val Ile Ser Asn His Leu Ile Leu Asn Lys Ile 
                85                  90                  95      


Asn Glu Ala Phe Ile Glu Met Ala Thr Thr Glu Asp Ala 
            100                 105                 


<210>  8354
<211>  125
<212>  PRT
<213>  Homo Sapiens

<400>  8354

Met Gly Asp Pro Phe Met Leu Gln Gln Ser Thr Asn Pro Ala Pro Gly 
1               5                   10                  15      


Ile Leu Gly Pro Pro Pro Pro Ser Phe His Leu Gly Gly Pro Ala Val 
            20                  25                  30          


Gly Pro Arg Gly Asn Leu Gly Ala Gly Asn Gly Asn Leu Gln Gly Pro 
        35                  40                  45              


Arg His Met Gln Lys Gly Arg Val Glu Thr Ser Arg Val Val His Ile 
    50                  55                  60                  


Met Asp Phe Gln Arg Gly Lys Asn Leu Arg Tyr Gln Leu Leu Gln Leu 
65                  70                  75                  80  


Val Glu Pro Phe Gly Val Ile Ser Asn His Leu Ile Leu Asn Lys Ile 
                85                  90                  95      


Asn Glu Ala Phe Ile Glu Met Ala Thr Thr Glu Asp Ala Gln Ala Ala 
            100                 105                 110         


Val Asp Tyr Tyr Thr Thr Thr Pro Ala Leu Val Phe Gly 
        115                 120                 125 


<210>  8355
<211>  509
<212>  PRT
<213>  Homo Sapiens

<400>  8355

Met Gly Asp Pro Phe Met Leu Gln Gln Ser Thr Asn Pro Ala Pro Gly 
1               5                   10                  15      


Ile Leu Gly Pro Pro Pro Pro Ser Phe His Leu Gly Gly Pro Ala Val 
            20                  25                  30          


Gly Pro Arg Gly Asn Leu Gly Ala Gly Asn Gly Asn Leu Gln Gly Pro 
        35                  40                  45              


Arg His Met Gln Lys Gly Arg Val Glu Thr Ser Arg Val Val His Ile 
    50                  55                  60                  


Met Asp Phe Gln Arg Gly Lys Asn Leu Arg Tyr Gln Leu Leu Gln Leu 
65                  70                  75                  80  


Val Glu Pro Phe Gly Val Ile Ser Asn His Leu Ile Leu Asn Lys Ile 
                85                  90                  95      


Asn Glu Ala Phe Ile Glu Met Ala Thr Thr Glu Asp Ala Gln Ala Ala 
            100                 105                 110         


Val Asp Tyr Tyr Thr Thr Thr Pro Ala Leu Val Phe Gly Lys Pro Val 
        115                 120                 125             


Arg Val His Leu Ser Gln Lys Tyr Lys Arg Ile Lys Lys Pro Glu Gly 
    130                 135                 140                 


Lys Pro Asp Gln Lys Phe Asp Gln Lys Gln Glu Leu Gly Arg Val Ile 
145                 150                 155                 160 


His Leu Ser Asn Leu Pro His Ser Gly Tyr Ser Asp Ser Ala Val Leu 
                165                 170                 175     


Lys Leu Ala Glu Pro Tyr Gly Lys Ile Lys Asn Tyr Ile Leu Met Arg 
            180                 185                 190         


Met Lys Ser Gln Ala Phe Ile Glu Met Glu Thr Arg Glu Asp Ala Met 
        195                 200                 205             


Ala Met Val Asp His Cys Leu Lys Lys Ala Leu Trp Phe Gln Gly Arg 
    210                 215                 220                 


Cys Val Lys Val Asp Leu Ser Glu Lys Tyr Lys Lys Leu Val Leu Arg 
225                 230                 235                 240 


Ile Pro Asn Arg Gly Ile Asp Leu Leu Lys Lys Asp Lys Ser Arg Lys 
                245                 250                 255     


Arg Ser Tyr Ser Pro Asp Gly Lys Glu Ser Pro Ser Asp Lys Lys Ser 
            260                 265                 270         


Lys Thr Asp Gly Ser Gln Lys Thr Glu Ser Ser Thr Glu Gly Lys Glu 
        275                 280                 285             


Gln Glu Glu Lys Ser Gly Glu Asp Gly Glu Lys Asp Thr Lys Asp Asp 
    290                 295                 300                 


Gln Thr Glu Gln Glu Pro Asn Met Leu Leu Glu Ser Glu Asp Glu Leu 
305                 310                 315                 320 


Leu Val Asp Glu Glu Glu Ala Ala Ala Leu Leu Glu Ser Gly Ser Ser 
                325                 330                 335     


Val Gly Asp Glu Thr Asp Leu Ala Asn Leu Gly Asp Val Ala Ser Asp 
            340                 345                 350         


Gly Lys Lys Glu Pro Ser Asp Lys Ala Val Lys Lys Asp Gly Ser Ala 
        355                 360                 365             


Ser Ala Ala Ala Lys Lys Lys Leu Lys Lys Val Asp Lys Ile Glu Glu 
    370                 375                 380                 


Leu Asp Gln Glu Asn Glu Ala Ala Leu Glu Asn Gly Ile Lys Asn Glu 
385                 390                 395                 400 


Glu Asn Thr Glu Pro Gly Ala Glu Ser Ser Glu Asn Ala Asp Asp Pro 
                405                 410                 415     


Asn Lys Asp Thr Ser Glu Asn Ala Asp Gly Gln Ser Asp Glu Asn Lys 
            420                 425                 430         


Asp Asp Tyr Thr Ile Pro Asp Glu Tyr Arg Ile Gly Pro Tyr Gln Pro 
        435                 440                 445             


Asn Val Pro Val Gly Ile Asp Tyr Val Ile Pro Lys Thr Gly Phe Tyr 
    450                 455                 460                 


Cys Lys Leu Cys Ser Leu Phe Tyr Thr Asn Glu Glu Val Ala Lys Asn 
465                 470                 475                 480 


Thr His Cys Ser Ser Leu Pro His Tyr Gln Lys Leu Lys Lys Phe Leu 
                485                 490                 495     


Asn Lys Leu Ala Glu Glu Arg Arg Gln Lys Lys Glu Thr 
            500                 505                 


<210>  8356
<211>  509
<212>  PRT
<213>  Homo Sapiens

<400>  8356

Met Gly Asp Pro Phe Met Leu Gln Gln Ser Thr Asn Pro Ala Pro Gly 
1               5                   10                  15      


Ile Leu Gly Pro Pro Pro Pro Ser Phe His Leu Gly Gly Pro Ala Val 
            20                  25                  30          


Gly Pro Arg Gly Asn Leu Gly Ala Gly Asn Gly Asn Leu Gln Gly Pro 
        35                  40                  45              


Arg His Met Gln Lys Gly Arg Val Glu Thr Ser Arg Val Val His Ile 
    50                  55                  60                  


Met Asp Phe Gln Arg Gly Lys Asn Leu Arg Tyr Gln Leu Leu Gln Leu 
65                  70                  75                  80  


Val Glu Pro Phe Gly Val Ile Ser Asn His Leu Ile Leu Asn Lys Ile 
                85                  90                  95      


Asn Glu Ala Phe Ile Glu Met Ala Thr Thr Glu Asp Ala Gln Ala Ala 
            100                 105                 110         


Val Asp Tyr Tyr Thr Thr Thr Pro Ala Leu Val Phe Gly Lys Pro Val 
        115                 120                 125             


Arg Val His Leu Ser Gln Lys Tyr Lys Arg Ile Lys Lys Pro Glu Gly 
    130                 135                 140                 


Lys Pro Asp Gln Lys Phe Asp Gln Lys Gln Glu Leu Gly Arg Val Ile 
145                 150                 155                 160 


His Leu Ser Asn Leu Pro His Ser Gly Tyr Ser Asp Ser Ala Val Leu 
                165                 170                 175     


Lys Leu Ala Glu Pro Tyr Gly Lys Ile Lys Asn Tyr Ile Leu Met Arg 
            180                 185                 190         


Met Lys Ser Gln Ala Phe Ile Glu Met Glu Thr Arg Glu Asp Ala Met 
        195                 200                 205             


Ala Met Val Asp His Cys Leu Lys Lys Ala Leu Trp Phe Gln Gly Arg 
    210                 215                 220                 


Cys Val Lys Val Asp Leu Ser Glu Lys Tyr Lys Lys Leu Val Leu Arg 
225                 230                 235                 240 


Ile Pro Asn Arg Gly Ile Asp Leu Leu Lys Lys Asp Lys Ser Arg Lys 
                245                 250                 255     


Arg Ser Tyr Ser Pro Asp Gly Lys Glu Ser Pro Ser Asp Lys Lys Ser 
            260                 265                 270         


Lys Thr Asp Gly Ser Gln Lys Thr Glu Ser Ser Thr Glu Gly Lys Glu 
        275                 280                 285             


Gln Glu Glu Lys Ser Gly Glu Asp Gly Glu Lys Asp Thr Lys Asp Asp 
    290                 295                 300                 


Gln Thr Glu Gln Glu Pro Asn Met Leu Leu Glu Ser Glu Asp Glu Leu 
305                 310                 315                 320 


Leu Val Asp Glu Glu Glu Ala Ala Ala Leu Leu Glu Ser Gly Ser Ser 
                325                 330                 335     


Val Gly Asp Glu Thr Asp Leu Ala Asn Leu Gly Asp Val Ala Ser Asp 
            340                 345                 350         


Gly Lys Lys Glu Pro Ser Asp Lys Ala Val Lys Lys Asp Gly Ser Ala 
        355                 360                 365             


Ser Ala Ala Ala Lys Lys Lys Leu Lys Lys Val Asp Lys Ile Glu Glu 
    370                 375                 380                 


Leu Asp Gln Glu Asn Glu Ala Ala Leu Glu Asn Gly Ile Lys Asn Glu 
385                 390                 395                 400 


Glu Asn Thr Glu Pro Gly Ala Glu Ser Ser Glu Asn Ala Asp Asp Pro 
                405                 410                 415     


Asn Lys Asp Thr Ser Glu Asn Ala Asp Gly Gln Ser Asp Glu Asn Lys 
            420                 425                 430         


Asp Asp Tyr Thr Ile Pro Asp Glu Tyr Arg Ile Gly Pro Tyr Gln Pro 
        435                 440                 445             


Asn Val Pro Val Gly Ile Asp Tyr Val Ile Pro Lys Thr Gly Phe Tyr 
    450                 455                 460                 


Cys Lys Leu Cys Ser Leu Phe Tyr Thr Asn Glu Glu Val Ala Lys Asn 
465                 470                 475                 480 


Thr His Cys Ser Ser Leu Pro His Tyr Gln Lys Leu Lys Lys Phe Leu 
                485                 490                 495     


Asn Lys Leu Ala Glu Glu Arg Arg Gln Lys Lys Glu Thr 
            500                 505                 


<210>  8357
<211>  559
<212>  PRT
<213>  Homo Sapiens

<400>  8357

Met Leu Gly Ala Gln Trp Arg Arg Asn Gln Pro Ser Arg Ala Ala Glu 
1               5                   10                  15      


Glu Trp Ser Gln His Ile Asn Gly Ala Ser His Ser Arg Arg Cys Gln 
            20                  25                  30          


Leu Leu Leu Glu Ile Tyr Pro Glu Trp Asn Pro Asp Asn Asp Thr Gly 
        35                  40                  45              


His Thr Met Gly Asp Pro Phe Met Leu Gln Gln Ser Thr Asn Pro Ala 
    50                  55                  60                  


Pro Gly Ile Leu Gly Pro Pro Pro Pro Ser Phe His Leu Gly Gly Pro 
65                  70                  75                  80  


Ala Val Gly Pro Arg Gly Asn Leu Gly Ala Gly Asn Gly Asn Leu Gln 
                85                  90                  95      


Gly Pro Arg His Met Gln Lys Gly Arg Val Glu Thr Ser Arg Val Val 
            100                 105                 110         


His Ile Met Asp Phe Gln Arg Gly Lys Asn Leu Arg Tyr Gln Leu Leu 
        115                 120                 125             


Gln Leu Val Glu Pro Phe Gly Val Ile Ser Asn His Leu Ile Leu Asn 
    130                 135                 140                 


Lys Ile Asn Glu Ala Phe Ile Glu Met Ala Thr Thr Glu Asp Ala Gln 
145                 150                 155                 160 


Ala Ala Val Asp Tyr Tyr Thr Thr Thr Pro Ala Leu Val Phe Gly Lys 
                165                 170                 175     


Pro Val Arg Val His Leu Ser Gln Lys Tyr Lys Arg Ile Lys Lys Pro 
            180                 185                 190         


Glu Gly Lys Pro Asp Gln Lys Phe Asp Gln Lys Gln Glu Leu Gly Arg 
        195                 200                 205             


Val Ile His Leu Ser Asn Leu Pro His Ser Gly Tyr Ser Asp Ser Ala 
    210                 215                 220                 


Val Leu Lys Leu Ala Glu Pro Tyr Gly Lys Ile Lys Asn Tyr Ile Leu 
225                 230                 235                 240 


Met Arg Met Lys Ser Gln Ala Phe Ile Glu Met Glu Thr Arg Glu Asp 
                245                 250                 255     


Ala Met Ala Met Val Asp His Cys Leu Lys Lys Ala Leu Trp Phe Gln 
            260                 265                 270         


Gly Arg Cys Val Lys Val Asp Leu Ser Glu Lys Tyr Lys Lys Leu Val 
        275                 280                 285             


Leu Arg Ile Pro Asn Arg Gly Ile Asp Leu Leu Lys Lys Asp Lys Ser 
    290                 295                 300                 


Arg Lys Arg Ser Tyr Ser Pro Asp Gly Lys Glu Ser Pro Ser Asp Lys 
305                 310                 315                 320 


Lys Ser Lys Thr Asp Gly Ser Gln Lys Thr Glu Ser Ser Thr Glu Gly 
                325                 330                 335     


Lys Glu Gln Glu Glu Lys Ser Gly Glu Asp Gly Glu Lys Asp Thr Lys 
            340                 345                 350         


Asp Asp Gln Thr Glu Gln Glu Pro Asn Met Leu Leu Glu Ser Glu Asp 
        355                 360                 365             


Glu Leu Leu Val Asp Glu Glu Glu Ala Ala Ala Leu Leu Glu Ser Gly 
    370                 375                 380                 


Ser Ser Val Gly Asp Glu Thr Asp Leu Ala Asn Leu Gly Asp Val Ala 
385                 390                 395                 400 


Ser Asp Gly Lys Lys Glu Pro Ser Asp Lys Ala Val Lys Lys Asp Gly 
                405                 410                 415     


Ser Ala Ser Ala Ala Ala Lys Lys Lys Leu Lys Lys Val Asp Lys Ile 
            420                 425                 430         


Glu Glu Leu Asp Gln Glu Asn Glu Ala Ala Leu Glu Asn Gly Ile Lys 
        435                 440                 445             


Asn Glu Glu Asn Thr Glu Pro Gly Ala Glu Ser Ser Glu Asn Ala Asp 
    450                 455                 460                 


Asp Pro Asn Lys Asp Thr Ser Glu Asn Ala Asp Gly Gln Ser Asp Glu 
465                 470                 475                 480 


Asn Lys Asp Asp Tyr Thr Ile Pro Asp Glu Tyr Arg Ile Gly Pro Tyr 
                485                 490                 495     


Gln Pro Asn Val Pro Val Gly Ile Asp Tyr Val Ile Pro Lys Thr Gly 
            500                 505                 510         


Phe Tyr Cys Lys Leu Cys Ser Leu Phe Tyr Thr Asn Glu Glu Val Ala 
        515                 520                 525             


Lys Asn Thr His Cys Ser Ser Leu Pro His Tyr Gln Lys Leu Lys Lys 
    530                 535                 540                 


Phe Leu Asn Lys Leu Ala Glu Glu Arg Arg Gln Lys Lys Glu Thr 
545                 550                 555                 


<210>  8358
<211>  172
<212>  PRT
<213>  Homo Sapiens

<400>  8358

Met Leu Gly Ala Gln Trp Arg Arg Asn Gln Pro Ser Arg Ala Ala Glu 
1               5                   10                  15      


Val Ser Gly Pro Gly Gly Lys His Ala Ala Gly Gln Gly Pro Arg Val 
            20                  25                  30          


Arg Arg Glu Ile Leu Gly Glu Glu Glu Trp Ser Gln His Ile Asn Gly 
        35                  40                  45              


Ala Ser His Ser Arg Arg Cys Gln Leu Leu Leu Glu Ile Tyr Pro Glu 
    50                  55                  60                  


Trp Asn Pro Asp Asn Asp Thr Gly His Thr Met Gly Asp Pro Phe Met 
65                  70                  75                  80  


Leu Gln Gln Ser Thr Asn Pro Ala Pro Gly Ile Leu Gly Pro Pro Pro 
                85                  90                  95      


Pro Ser Phe His Leu Gly Gly Pro Ala Val Gly Pro Arg Gly Asn Leu 
            100                 105                 110         


Gly Ala Gly Asn Gly Asn Leu Gln Gly Pro Arg His Met Gln Lys Gly 
        115                 120                 125             


Arg Val Glu Thr Ser Arg Val Val His Ile Met Asp Phe Gln Arg Gly 
    130                 135                 140                 


Lys Asn Leu Arg Tyr Gln Leu Leu Gln Leu Val Glu Pro Phe Gly Val 
145                 150                 155                 160 


Ile Ser Asn His Leu Ile Leu Asn Lys Ile Asn Glu 
                165                 170         


<210>  8359
<211>  283
<212>  PRT
<213>  Homo Sapiens

<400>  8359

Met Ser Lys Ser Phe Gln Gln Ser Ser Leu Ser Arg Asp Ser Gln Gly 
1               5                   10                  15      


His Gly Arg Asp Leu Ser Ala Ala Gly Ile Gly Leu Leu Ala Ala Ala 
            20                  25                  30          


Thr Gln Ser Leu Ser Met Leu Leu Glu Ser Glu Asp Glu Leu Leu Val 
        35                  40                  45              


Asp Glu Glu Glu Ala Ala Ala Leu Leu Glu Ser Gly Ser Ser Val Gly 
    50                  55                  60                  


Asp Glu Thr Asp Leu Ala Asn Leu Gly Asp Val Ala Ser Asp Gly Lys 
65                  70                  75                  80  


Lys Glu Pro Ser Asp Lys Ala Val Lys Lys Asp Gly Ser Ala Ser Ala 
                85                  90                  95      


Ala Ala Lys Lys Lys Leu Lys Lys Arg Arg Phe Pro Gly Ser Met Glu 
            100                 105                 110         


Gly Phe Val Thr Leu Asp Glu Val Gly Asp Glu Glu Asp Ser Glu Leu 
        115                 120                 125             


Gln Lys Leu Arg Lys Ser Gly Met Ala Phe Lys Ser Gly Asp Lys Asn 
    130                 135                 140                 


Asp Asp Gly Leu Val Glu Ile Lys Val Asp Lys Ile Glu Glu Leu Asp 
145                 150                 155                 160 


Gln Glu Asn Glu Ala Ala Leu Glu Asn Gly Ile Lys Asn Glu Glu Asn 
                165                 170                 175     


Thr Glu Pro Gly Ala Glu Ser Ser Glu Asn Ala Asp Asp Pro Asn Lys 
            180                 185                 190         


Asp Thr Ser Glu Asn Ala Asp Gly Gln Ser Asp Glu Asn Lys Asp Asp 
        195                 200                 205             


Tyr Thr Ile Pro Asp Glu Tyr Arg Ile Gly Pro Tyr Gln Pro Asn Val 
    210                 215                 220                 


Pro Val Gly Ile Asp Tyr Val Ile Pro Lys Thr Gly Phe Tyr Cys Lys 
225                 230                 235                 240 


Leu Cys Ser Leu Phe Tyr Thr Asn Glu Glu Val Ala Lys Asn Thr His 
                245                 250                 255     


Cys Ser Ser Leu Pro His Tyr Gln Lys Leu Lys Lys Phe Leu Asn Lys 
            260                 265                 270         


Leu Ala Glu Glu Arg Arg Gln Lys Lys Glu Thr 
        275                 280             


<210>  8360
<211>  47
<212>  PRT
<213>  Homo Sapiens

<400>  8360

Met Ser Lys Ser Phe Gln Gln Ser Ser Leu Ser Arg Asp Ser Gln Gly 
1               5                   10                  15      


His Gly Arg Asp Leu Ser Ala Ala Gly Ile Gly Leu Leu Ala Ala Ala 
            20                  25                  30          


Thr Gln Ser Leu Ser Met Pro Ala Ser Leu Gly Arg Met Asn Gln 
        35                  40                  45          


<210>  8361
<211>  78
<212>  PRT
<213>  Homo Sapiens

<400>  8361

Met Ser Lys Ser Phe Gln Gln Ser Ser Leu Ser Arg Asp Ser Gln Gly 
1               5                   10                  15      


His Gly Arg Asp Leu Ser Ala Ala Gly Ile Gly Leu Leu Ala Ala Ala 
            20                  25                  30          


Thr Gln Ser Leu Ser Met Pro Ala Ser Leu Gly Arg Met Asn Gln Gly 
        35                  40                  45              


Thr Ala Arg Leu Ala Ser Leu Met Asn Leu Gly Met Ser Ser Ser Leu 
    50                  55                  60                  


Asn Gln Gln Gly Ala His Ser Ala Leu Ser Ser Ala Ser Thr 
65                  70                  75              


<210>  8362
<211>  78
<212>  PRT
<213>  Homo Sapiens

<400>  8362

Met Ser Lys Ser Phe Gln Gln Ser Ser Leu Ser Arg Asp Ser Gln Gly 
1               5                   10                  15      


His Gly Arg Asp Leu Ser Ala Ala Gly Ile Gly Leu Leu Ala Ala Ala 
            20                  25                  30          


Thr Gln Ser Leu Ser Met Pro Ala Ser Leu Gly Arg Met Asn Gln Gly 
        35                  40                  45              


Thr Ala Arg Leu Ala Ser Leu Met Asn Leu Gly Met Ser Ser Ser Leu 
    50                  55                  60                  


Asn Gln Gln Gly Ala His Ser Ala Leu Ser Ser Ala Ser Thr 
65                  70                  75              


<210>  8363
<211>  87
<212>  PRT
<213>  Homo Sapiens

<400>  8363

Met Ser Lys Ser Phe Gln Gln Ser Ser Leu Ser Arg Asp Ser Gln Gly 
1               5                   10                  15      


His Gly Arg Asp Leu Ser Ala Ala Gly Ile Gly Leu Leu Ala Ala Ala 
            20                  25                  30          


Thr Gln Ser Leu Ser Met Pro Ala Ser Leu Gly Arg Met Asn Gln Gly 
        35                  40                  45              


Thr Ala Arg Leu Ala Ser Leu Met Asn Leu Gly Met Ser Ser Ser Leu 
    50                  55                  60                  


Asn Gln Gln Gly Ala His Ser Ala Leu Ser Ser Ala Ser Thr Ser Ser 
65                  70                  75                  80  


His Asn Leu Gln Ser Ile Phe 
                85          


<210>  8364
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  8364

Met Ser Lys Ser Phe Gln Gln Ser Ser Leu Ser Arg Asp Ser Gln Gly 
1               5                   10                  15      


His Gly Arg Asp Leu Ser Ala Ala Gly Ile Gly Leu Leu Ala Ala Ala 
            20                  25                  30          


Thr Gln Ser Leu Ser Met Pro Ala Ser Leu Gly Arg Met Asn Gln Gly 
        35                  40                  45              


Thr Ala Arg Leu Ala Ser Leu Met Asn Leu Gly Met Ser Ser Ser Leu 
    50                  55                  60                  


Asn Gln Gln Gly Ala His Ser Ala Leu Ser Ser Ala Ser Thr Ser Ser 
65                  70                  75                  80  


His Asn Leu Gln Ser Ile Phe Asn Ile Gly Ser Arg Gly Pro Leu Pro 
                85                  90                  95      


Leu Ser Ser 
            


<210>  8365
<211>  100
<212>  PRT
<213>  Homo Sapiens

<400>  8365

Met Ser Lys Ser Phe Gln Gln Ser Ser Leu Ser Arg Asp Ser Gln Gly 
1               5                   10                  15      


His Gly Arg Asp Leu Ser Ala Ala Gly Ile Gly Leu Leu Ala Ala Ala 
            20                  25                  30          


Thr Gln Ser Leu Ser Met Pro Ala Ser Leu Gly Arg Met Asn Gln Gly 
        35                  40                  45              


Thr Ala Arg Leu Ala Ser Leu Met Asn Leu Gly Met Ser Ser Ser Leu 
    50                  55                  60                  


Asn Gln Gln Gly Ala His Ser Ala Leu Ser Ser Ala Ser Thr Ser Ser 
65                  70                  75                  80  


His Asn Leu Gln Ser Ile Phe Asn Ile Gly Ser Arg Gly Pro Leu Pro 
                85                  90                  95      


Leu Ser Ser Gln 
            100 


<210>  8366
<211>  107
<212>  PRT
<213>  Homo Sapiens

<400>  8366

Met Ser Lys Ser Phe Gln Gln Ser Ser Leu Ser Arg Asp Ser Gln Gly 
1               5                   10                  15      


His Gly Arg Asp Leu Ser Ala Ala Gly Ile Gly Leu Leu Ala Ala Ala 
            20                  25                  30          


Thr Gln Ser Leu Ser Met Pro Ala Ser Leu Gly Arg Met Asn Gln Gly 
        35                  40                  45              


Thr Ala Arg Leu Ala Ser Leu Met Asn Leu Gly Met Ser Ser Ser Leu 
    50                  55                  60                  


Asn Gln Gln Gly Ala His Ser Ala Leu Ser Ser Ala Ser Thr Ser Ser 
65                  70                  75                  80  


His Asn Leu Gln Ser Ile Phe Asn Ile Gly Ser Arg Gly Pro Leu Pro 
                85                  90                  95      


Leu Ser Ser Gln His Arg Gly Asp Ala Asp Gln 
            100                 105         


<210>  8367
<211>  847
<212>  PRT
<213>  Homo Sapiens

<400>  8367

Met Ser Lys Ser Phe Gln Gln Ser Ser Leu Ser Arg Asp Ser Gln Gly 
1               5                   10                  15      


His Gly Arg Asp Leu Ser Ala Ala Gly Ile Gly Leu Leu Ala Ala Ala 
            20                  25                  30          


Thr Gln Ser Leu Ser Met Pro Ala Ser Leu Gly Arg Met Asn Gln Gly 
        35                  40                  45              


Thr Ala Arg Leu Ala Ser Leu Met Asn Leu Gly Met Ser Ser Ser Leu 
    50                  55                  60                  


Asn Gln Gln Gly Ala His Ser Ala Leu Ser Ser Ala Ser Thr Ser Ser 
65                  70                  75                  80  


His Asn Leu Gln Ser Ile Phe Asn Ile Gly Ser Arg Gly Pro Leu Pro 
                85                  90                  95      


Leu Ser Ser Gln His Arg Gly Asp Ala Asp Gln Ala Ser Asn Ile Leu 
            100                 105                 110         


Ala Ser Phe Gly Leu Ser Ala Arg Asp Leu Asp Glu Leu Ser Arg Tyr 
        115                 120                 125             


Pro Glu Asp Lys Ile Thr Pro Glu Asn Leu Pro Gln Ile Leu Leu Gln 
    130                 135                 140                 


Leu Lys Arg Arg Arg Thr Glu Glu Gly Pro Thr Leu Ser Tyr Gly Arg 
145                 150                 155                 160 


Asp Gly Arg Ser Ala Thr Arg Glu Pro Pro Tyr Arg Val Pro Arg Asp 
                165                 170                 175     


Asp Trp Glu Glu Lys Arg His Phe Arg Arg Asp Ser Phe Asp Asp Arg 
            180                 185                 190         


Gly Pro Ser Leu Asn Pro Val Leu Asp Tyr Asp His Gly Ser Arg Ser 
        195                 200                 205             


Gln Glu Ser Gly Tyr Tyr Asp Arg Met Asp Tyr Glu Asp Asp Arg Leu 
    210                 215                 220                 


Arg Asp Gly Glu Arg Cys Arg Asp Asp Ser Phe Phe Gly Glu Thr Ser 
225                 230                 235                 240 


His Asn Tyr His Lys Phe Asp Ser Glu Tyr Glu Arg Met Gly Arg Gly 
                245                 250                 255     


Pro Gly Pro Leu Gln Glu Arg Ser Leu Phe Glu Lys Lys Arg Gly Ala 
            260                 265                 270         


Pro Pro Ser Ser Asn Ile Glu Asp Phe His Gly Leu Leu Pro Lys Gly 
        275                 280                 285             


Tyr Pro His Leu Cys Ser Ile Cys Asp Leu Pro Val His Ser Asn Lys 
    290                 295                 300                 


Glu Trp Ser Gln His Ile Asn Gly Ala Ser His Ser Arg Arg Cys Gln 
305                 310                 315                 320 


Leu Leu Leu Glu Ile Tyr Pro Glu Trp Asn Pro Asp Asn Asp Thr Gly 
                325                 330                 335     


His Thr Met Gly Asp Pro Phe Met Leu Gln Gln Ser Thr Asn Pro Ala 
            340                 345                 350         


Pro Gly Ile Leu Gly Pro Pro Pro Pro Ser Phe His Leu Gly Gly Pro 
        355                 360                 365             


Ala Val Gly Pro Arg Gly Asn Leu Gly Ala Gly Asn Gly Asn Leu Gln 
    370                 375                 380                 


Gly Pro Arg His Met Gln Lys Gly Arg Val Glu Thr Ser Arg Val Val 
385                 390                 395                 400 


His Ile Met Asp Phe Gln Arg Gly Lys Asn Leu Arg Tyr Gln Leu Leu 
                405                 410                 415     


Gln Leu Val Glu Pro Phe Gly Val Ile Ser Asn His Leu Ile Leu Asn 
            420                 425                 430         


Lys Ile Asn Glu Ala Phe Ile Glu Met Ala Thr Thr Glu Asp Ala Gln 
        435                 440                 445             


Ala Ala Val Asp Tyr Tyr Thr Thr Thr Pro Ala Leu Val Phe Gly Lys 
    450                 455                 460                 


Pro Val Arg Val His Leu Ser Gln Lys Tyr Lys Arg Ile Lys Lys Pro 
465                 470                 475                 480 


Glu Gly Lys Pro Asp Gln Lys Phe Asp Gln Lys Gln Glu Leu Gly Arg 
                485                 490                 495     


Val Ile His Leu Ser Asn Leu Pro His Ser Gly Tyr Ser Asp Ser Ala 
            500                 505                 510         


Val Leu Lys Leu Ala Glu Pro Tyr Gly Lys Ile Lys Asn Tyr Ile Leu 
        515                 520                 525             


Met Arg Met Lys Ser Gln Ala Phe Ile Glu Met Glu Thr Arg Glu Asp 
    530                 535                 540                 


Ala Met Ala Met Val Asp His Cys Leu Lys Lys Ala Leu Trp Phe Gln 
545                 550                 555                 560 


Gly Arg Cys Val Lys Val Asp Leu Ser Glu Lys Tyr Lys Lys Leu Val 
                565                 570                 575     


Leu Arg Ile Pro Asn Arg Gly Ile Asp Leu Leu Lys Lys Asp Lys Ser 
            580                 585                 590         


Arg Lys Arg Ser Tyr Ser Pro Asp Gly Lys Glu Ser Pro Ser Asp Lys 
        595                 600                 605             


Lys Ser Lys Thr Asp Gly Ser Gln Lys Thr Glu Ser Ser Thr Glu Gly 
    610                 615                 620                 


Lys Glu Gln Glu Glu Lys Ser Gly Glu Asp Gly Glu Lys Asp Thr Lys 
625                 630                 635                 640 


Asp Asp Gln Thr Glu Gln Glu Pro Asn Met Leu Leu Glu Ser Glu Asp 
                645                 650                 655     


Glu Leu Leu Val Asp Glu Glu Glu Ala Ala Ala Leu Leu Glu Ser Gly 
            660                 665                 670         


Ser Ser Val Gly Asp Glu Thr Asp Leu Ala Asn Leu Gly Asp Val Ala 
        675                 680                 685             


Ser Asp Gly Lys Lys Glu Pro Ser Asp Lys Ala Val Lys Lys Asp Gly 
    690                 695                 700                 


Ser Ala Ser Ala Ala Ala Lys Lys Lys Leu Lys Lys Val Asp Lys Ile 
705                 710                 715                 720 


Glu Glu Leu Asp Gln Glu Asn Glu Ala Ala Leu Glu Asn Gly Ile Lys 
                725                 730                 735     


Asn Glu Glu Asn Thr Glu Pro Gly Ala Glu Ser Ser Glu Asn Ala Asp 
            740                 745                 750         


Asp Pro Asn Lys Asp Thr Ser Glu Asn Ala Asp Gly Gln Ser Asp Glu 
        755                 760                 765             


Asn Lys Asp Asp Tyr Thr Ile Pro Asp Glu Tyr Arg Ile Gly Pro Tyr 
    770                 775                 780                 


Gln Pro Asn Val Pro Val Gly Ile Asp Tyr Val Ile Pro Lys Thr Gly 
785                 790                 795                 800 


Phe Tyr Cys Lys Leu Cys Ser Leu Phe Tyr Thr Asn Glu Glu Val Ala 
                805                 810                 815     


Lys Asn Thr His Cys Ser Ser Leu Pro His Tyr Gln Lys Leu Lys Lys 
            820                 825                 830         


Phe Leu Asn Lys Leu Ala Glu Glu Arg Arg Gln Lys Lys Glu Thr 
        835                 840                 845         


<210>  8368
<211>  895
<212>  PRT
<213>  Homo Sapiens

<400>  8368

Met Ser Lys Ser Phe Gln Gln Ser Ser Leu Ser Arg Asp Ser Gln Gly 
1               5                   10                  15      


His Gly Arg Asp Leu Ser Ala Ala Gly Ile Gly Leu Leu Ala Ala Ala 
            20                  25                  30          


Thr Gln Ser Leu Ser Met Pro Ala Ser Leu Gly Arg Met Asn Gln Gly 
        35                  40                  45              


Thr Ala Arg Leu Ala Ser Leu Met Asn Leu Gly Met Ser Ser Ser Leu 
    50                  55                  60                  


Asn Gln Gln Gly Ala His Ser Ala Leu Ser Ser Ala Ser Thr Ser Ser 
65                  70                  75                  80  


His Asn Leu Gln Ser Ile Phe Asn Ile Gly Ser Arg Gly Pro Leu Pro 
                85                  90                  95      


Leu Ser Ser Gln His Arg Gly Asp Ala Asp Gln Ala Ser Asn Ile Leu 
            100                 105                 110         


Ala Ser Phe Gly Leu Ser Ala Arg Asp Leu Asp Glu Leu Ser Arg Tyr 
        115                 120                 125             


Pro Glu Asp Lys Ile Thr Pro Glu Asn Leu Pro Gln Ile Leu Leu Gln 
    130                 135                 140                 


Leu Lys Arg Arg Arg Thr Glu Glu Gly Pro Thr Leu Ser Tyr Gly Arg 
145                 150                 155                 160 


Asp Gly Arg Ser Ala Thr Arg Glu Pro Pro Tyr Arg Val Pro Arg Asp 
                165                 170                 175     


Asp Trp Glu Glu Lys Arg His Phe Arg Arg Asp Ser Phe Asp Asp Arg 
            180                 185                 190         


Gly Pro Ser Leu Asn Pro Val Leu Asp Tyr Asp His Gly Ser Arg Ser 
        195                 200                 205             


Gln Glu Ser Gly Tyr Tyr Asp Arg Met Asp Tyr Glu Asp Asp Arg Leu 
    210                 215                 220                 


Arg Asp Gly Glu Arg Cys Arg Asp Asp Ser Phe Phe Gly Glu Thr Ser 
225                 230                 235                 240 


His Asn Tyr His Lys Phe Asp Ser Glu Tyr Glu Arg Met Gly Arg Gly 
                245                 250                 255     


Pro Gly Pro Leu Gln Glu Arg Ser Leu Phe Glu Lys Lys Arg Gly Ala 
            260                 265                 270         


Pro Pro Ser Ser Asn Ile Glu Asp Phe His Gly Leu Leu Pro Lys Gly 
        275                 280                 285             


Tyr Pro His Leu Cys Ser Ile Cys Asp Leu Pro Val His Ser Asn Lys 
    290                 295                 300                 


Glu Trp Ser Gln His Ile Asn Gly Ala Ser His Ser Arg Arg Cys Gln 
305                 310                 315                 320 


Leu Leu Leu Glu Ile Tyr Pro Glu Trp Asn Pro Asp Asn Asp Thr Gly 
                325                 330                 335     


His Thr Met Gly Asp Pro Phe Met Leu Gln Gln Ser Thr Asn Pro Ala 
            340                 345                 350         


Pro Gly Ile Leu Gly Pro Pro Pro Pro Ser Phe His Leu Gly Gly Pro 
        355                 360                 365             


Ala Val Gly Pro Arg Gly Asn Leu Gly Ala Gly Asn Gly Asn Leu Gln 
    370                 375                 380                 


Gly Pro Arg His Met Gln Lys Gly Arg Val Glu Thr Ser Arg Val Val 
385                 390                 395                 400 


His Ile Met Asp Phe Gln Arg Gly Lys Asn Leu Arg Tyr Gln Leu Leu 
                405                 410                 415     


Gln Leu Val Glu Pro Phe Gly Val Ile Ser Asn His Leu Ile Leu Asn 
            420                 425                 430         


Lys Ile Asn Glu Ala Phe Ile Glu Met Ala Thr Thr Glu Asp Ala Gln 
        435                 440                 445             


Ala Ala Val Asp Tyr Tyr Thr Thr Thr Pro Ala Leu Val Phe Gly Lys 
    450                 455                 460                 


Pro Val Arg Val His Leu Ser Gln Lys Tyr Lys Arg Ile Lys Lys Pro 
465                 470                 475                 480 


Glu Gly Lys Pro Asp Gln Lys Phe Asp Gln Lys Gln Glu Leu Gly Arg 
                485                 490                 495     


Val Ile His Leu Ser Asn Leu Pro His Ser Gly Tyr Ser Asp Ser Ala 
            500                 505                 510         


Val Leu Lys Leu Ala Glu Pro Tyr Gly Lys Ile Lys Asn Tyr Ile Leu 
        515                 520                 525             


Met Arg Met Lys Ser Gln Ala Phe Ile Glu Met Glu Thr Arg Glu Asp 
    530                 535                 540                 


Ala Met Ala Met Val Asp His Cys Leu Lys Lys Ala Leu Trp Phe Gln 
545                 550                 555                 560 


Gly Arg Cys Val Lys Val Asp Leu Ser Glu Lys Tyr Lys Lys Leu Val 
                565                 570                 575     


Leu Arg Ile Pro Asn Arg Gly Ile Asp Leu Leu Lys Lys Asp Lys Ser 
            580                 585                 590         


Arg Lys Arg Ser Tyr Ser Pro Asp Gly Lys Glu Ser Pro Ser Asp Lys 
        595                 600                 605             


Lys Ser Lys Thr Asp Gly Ser Gln Lys Thr Glu Ser Ser Thr Glu Gly 
    610                 615                 620                 


Lys Glu Gln Glu Glu Lys Ser Gly Glu Asp Gly Glu Lys Asp Thr Lys 
625                 630                 635                 640 


Asp Asp Gln Thr Glu Gln Glu Pro Asn Met Leu Leu Glu Ser Glu Asp 
                645                 650                 655     


Glu Leu Leu Val Asp Glu Glu Glu Ala Ala Ala Leu Leu Glu Ser Gly 
            660                 665                 670         


Ser Ser Val Gly Asp Glu Thr Asp Leu Ala Asn Leu Gly Asp Val Ala 
        675                 680                 685             


Ser Asp Gly Lys Lys Glu Pro Ser Asp Lys Ala Val Lys Lys Asp Gly 
    690                 695                 700                 


Ser Ala Ser Ala Ala Ala Lys Lys Lys Leu Lys Lys Arg Arg Phe Pro 
705                 710                 715                 720 


Gly Ser Met Glu Gly Phe Val Thr Leu Asp Glu Val Gly Asp Glu Glu 
                725                 730                 735     


Asp Ser Glu Leu Gln Lys Leu Arg Lys Ser Gly Met Ala Phe Lys Ser 
            740                 745                 750         


Gly Asp Lys Asn Asp Asp Gly Leu Val Glu Ile Lys Val Asp Lys Ile 
        755                 760                 765             


Glu Glu Leu Asp Gln Glu Asn Glu Ala Ala Leu Glu Asn Gly Ile Lys 
    770                 775                 780                 


Asn Glu Glu Asn Thr Glu Pro Gly Ala Glu Ser Ser Glu Asn Ala Asp 
785                 790                 795                 800 


Asp Pro Asn Lys Asp Thr Ser Glu Asn Ala Asp Gly Gln Ser Asp Glu 
                805                 810                 815     


Asn Lys Asp Asp Tyr Thr Ile Pro Asp Glu Tyr Arg Ile Gly Pro Tyr 
            820                 825                 830         


Gln Pro Asn Val Pro Val Gly Ile Asp Tyr Val Ile Pro Lys Thr Gly 
        835                 840                 845             


Phe Tyr Cys Lys Leu Cys Ser Leu Phe Tyr Thr Asn Glu Glu Val Ala 
    850                 855                 860                 


Lys Asn Thr His Cys Ser Ser Leu Pro His Tyr Gln Lys Leu Lys Lys 
865                 870                 875                 880 


Phe Leu Asn Lys Leu Ala Glu Glu Arg Arg Gln Lys Lys Glu Thr 
                885                 890                 895 


<210>  8369
<211>  847
<212>  PRT
<213>  Homo Sapiens

<400>  8369

Met Ser Lys Ser Phe Gln Gln Ser Ser Leu Ser Arg Asp Ser Gln Gly 
1               5                   10                  15      


His Gly Arg Asp Leu Ser Ala Ala Gly Ile Gly Leu Leu Ala Ala Ala 
            20                  25                  30          


Thr Gln Ser Leu Ser Met Pro Ala Ser Leu Gly Arg Met Asn Gln Gly 
        35                  40                  45              


Thr Ala Arg Leu Ala Ser Leu Met Asn Leu Gly Met Ser Ser Ser Leu 
    50                  55                  60                  


Asn Gln Gln Gly Ala His Ser Ala Leu Ser Ser Ala Ser Thr Ser Ser 
65                  70                  75                  80  


His Asn Leu Gln Ser Ile Phe Asn Ile Gly Ser Arg Gly Pro Leu Pro 
                85                  90                  95      


Leu Ser Ser Gln His Arg Gly Asp Ala Asp Gln Ala Ser Asn Ile Leu 
            100                 105                 110         


Ala Ser Phe Gly Leu Ser Ala Arg Asp Leu Asp Glu Leu Ser Arg Tyr 
        115                 120                 125             


Pro Glu Asp Lys Ile Thr Pro Glu Asn Leu Pro Gln Ile Leu Leu Gln 
    130                 135                 140                 


Leu Lys Arg Arg Arg Thr Glu Glu Gly Pro Thr Leu Ser Tyr Gly Arg 
145                 150                 155                 160 


Asp Gly Arg Ser Ala Thr Arg Glu Pro Pro Tyr Arg Val Pro Arg Asp 
                165                 170                 175     


Asp Trp Glu Glu Lys Arg His Phe Arg Arg Asp Ser Phe Asp Asp Arg 
            180                 185                 190         


Gly Pro Ser Leu Asn Pro Val Leu Asp Tyr Asp His Gly Ser Arg Ser 
        195                 200                 205             


Gln Glu Ser Gly Tyr Tyr Asp Arg Met Asp Tyr Glu Asp Asp Arg Leu 
    210                 215                 220                 


Arg Asp Gly Glu Arg Cys Arg Asp Asp Ser Phe Phe Gly Glu Thr Ser 
225                 230                 235                 240 


His Asn Tyr His Lys Phe Asp Ser Glu Tyr Glu Arg Met Gly Arg Gly 
                245                 250                 255     


Pro Gly Pro Leu Gln Glu Arg Ser Leu Phe Glu Lys Lys Arg Gly Ala 
            260                 265                 270         


Pro Pro Ser Ser Asn Ile Glu Asp Phe His Gly Leu Leu Pro Lys Gly 
        275                 280                 285             


Tyr Pro His Leu Cys Ser Ile Cys Asp Leu Pro Val His Ser Asn Lys 
    290                 295                 300                 


Glu Trp Ser Gln His Ile Asn Gly Ala Ser His Ser Arg Arg Cys Gln 
305                 310                 315                 320 


Leu Leu Leu Glu Ile Tyr Pro Glu Trp Asn Pro Asp Asn Asp Thr Gly 
                325                 330                 335     


His Thr Met Gly Asp Pro Phe Met Leu Gln Gln Ser Thr Asn Pro Ala 
            340                 345                 350         


Pro Gly Ile Leu Gly Pro Pro Pro Pro Ser Phe His Leu Gly Gly Pro 
        355                 360                 365             


Ala Val Gly Pro Arg Gly Asn Leu Gly Ala Gly Asn Gly Asn Leu Gln 
    370                 375                 380                 


Gly Pro Arg His Met Gln Lys Gly Arg Val Glu Thr Ser Arg Val Val 
385                 390                 395                 400 


His Ile Met Asp Phe Gln Arg Gly Lys Asn Leu Arg Tyr Gln Leu Leu 
                405                 410                 415     


Gln Leu Val Glu Pro Phe Gly Val Ile Ser Asn His Leu Ile Leu Asn 
            420                 425                 430         


Lys Ile Asn Glu Ala Phe Ile Glu Met Ala Thr Thr Glu Asp Ala Gln 
        435                 440                 445             


Ala Ala Val Asp Tyr Tyr Thr Thr Thr Pro Ala Leu Val Phe Gly Lys 
    450                 455                 460                 


Pro Val Arg Val His Leu Ser Gln Lys Tyr Lys Arg Ile Lys Lys Pro 
465                 470                 475                 480 


Glu Gly Lys Pro Asp Gln Lys Phe Asp Gln Lys Gln Glu Leu Gly Arg 
                485                 490                 495     


Val Ile His Leu Ser Asn Leu Pro His Ser Gly Tyr Ser Asp Ser Ala 
            500                 505                 510         


Val Leu Lys Leu Ala Glu Pro Tyr Gly Lys Ile Lys Asn Tyr Ile Leu 
        515                 520                 525             


Met Arg Met Lys Ser Gln Ala Phe Ile Glu Met Glu Thr Arg Glu Asp 
    530                 535                 540                 


Ala Met Ala Met Val Asp His Cys Leu Lys Lys Ala Leu Trp Phe Gln 
545                 550                 555                 560 


Gly Arg Cys Val Lys Val Asp Leu Ser Glu Lys Tyr Lys Lys Leu Val 
                565                 570                 575     


Leu Arg Ile Pro Asn Arg Gly Ile Asp Leu Leu Lys Lys Asp Lys Ser 
            580                 585                 590         


Arg Lys Arg Ser Tyr Ser Pro Asp Gly Lys Glu Ser Pro Ser Asp Lys 
        595                 600                 605             


Lys Ser Lys Thr Asp Gly Ser Gln Lys Thr Glu Ser Ser Thr Glu Gly 
    610                 615                 620                 


Lys Glu Gln Glu Glu Lys Ser Gly Glu Asp Gly Glu Lys Asp Thr Lys 
625                 630                 635                 640 


Asp Asp Gln Thr Glu Gln Glu Pro Asn Met Leu Leu Glu Ser Glu Asp 
                645                 650                 655     


Glu Leu Leu Val Asp Glu Glu Glu Ala Ala Ala Leu Leu Glu Ser Gly 
            660                 665                 670         


Ser Ser Val Gly Asp Glu Thr Asp Leu Ala Asn Leu Gly Asp Val Ala 
        675                 680                 685             


Ser Asp Gly Lys Lys Glu Pro Ser Asp Lys Ala Val Lys Lys Asp Gly 
    690                 695                 700                 


Ser Ala Ser Ala Ala Ala Lys Lys Lys Leu Lys Lys Val Asp Lys Ile 
705                 710                 715                 720 


Glu Glu Leu Asp Gln Glu Asn Glu Ala Ala Leu Glu Asn Gly Ile Lys 
                725                 730                 735     


Asn Glu Glu Asn Thr Glu Pro Gly Ala Glu Ser Ser Glu Asn Ala Asp 
            740                 745                 750         


Asp Pro Asn Lys Asp Thr Ser Glu Asn Ala Asp Gly Gln Ser Asp Glu 
        755                 760                 765             


Asn Lys Asp Asp Tyr Thr Ile Pro Asp Glu Tyr Arg Ile Gly Pro Tyr 
    770                 775                 780                 


Gln Pro Asn Val Pro Val Gly Ile Asp Tyr Val Ile Pro Lys Thr Gly 
785                 790                 795                 800 


Phe Tyr Cys Lys Leu Cys Ser Leu Phe Tyr Thr Asn Glu Glu Val Ala 
                805                 810                 815     


Lys Asn Thr His Cys Ser Ser Leu Pro His Tyr Gln Lys Leu Lys Lys 
            820                 825                 830         


Phe Leu Asn Lys Leu Ala Glu Glu Arg Arg Gln Lys Lys Glu Thr 
        835                 840                 845         


<210>  8370
<211>  895
<212>  PRT
<213>  Homo Sapiens

<400>  8370

Met Ser Lys Ser Phe Gln Gln Ser Ser Leu Ser Arg Asp Ser Gln Gly 
1               5                   10                  15      


His Gly Arg Asp Leu Ser Ala Ala Gly Ile Gly Leu Leu Ala Ala Ala 
            20                  25                  30          


Thr Gln Ser Leu Ser Met Pro Ala Ser Leu Gly Arg Met Asn Gln Gly 
        35                  40                  45              


Thr Ala Arg Leu Ala Ser Leu Met Asn Leu Gly Met Ser Ser Ser Leu 
    50                  55                  60                  


Asn Gln Gln Gly Ala His Ser Ala Leu Ser Ser Ala Ser Thr Ser Ser 
65                  70                  75                  80  


His Asn Leu Gln Ser Ile Phe Asn Ile Gly Ser Arg Gly Pro Leu Pro 
                85                  90                  95      


Leu Ser Ser Gln His Arg Gly Asp Ala Asp Gln Ala Ser Asn Ile Leu 
            100                 105                 110         


Ala Ser Phe Gly Leu Ser Ala Arg Asp Leu Asp Glu Leu Ser Arg Tyr 
        115                 120                 125             


Pro Glu Asp Lys Ile Thr Pro Glu Asn Leu Pro Gln Ile Leu Leu Gln 
    130                 135                 140                 


Leu Lys Arg Arg Arg Thr Glu Glu Gly Pro Thr Leu Ser Tyr Gly Arg 
145                 150                 155                 160 


Asp Gly Arg Ser Ala Thr Arg Glu Pro Pro Tyr Arg Val Pro Arg Asp 
                165                 170                 175     


Asp Trp Glu Glu Lys Arg His Phe Arg Arg Asp Ser Phe Asp Asp Arg 
            180                 185                 190         


Gly Pro Ser Leu Asn Pro Val Leu Asp Tyr Asp His Gly Ser Arg Ser 
        195                 200                 205             


Gln Glu Ser Gly Tyr Tyr Asp Arg Met Asp Tyr Glu Asp Asp Arg Leu 
    210                 215                 220                 


Arg Asp Gly Glu Arg Cys Arg Asp Asp Ser Phe Phe Gly Glu Thr Ser 
225                 230                 235                 240 


His Asn Tyr His Lys Phe Asp Ser Glu Tyr Glu Arg Met Gly Arg Gly 
                245                 250                 255     


Pro Gly Pro Leu Gln Glu Arg Ser Leu Phe Glu Lys Lys Arg Gly Ala 
            260                 265                 270         


Pro Pro Ser Ser Asn Ile Glu Asp Phe His Gly Leu Leu Pro Lys Gly 
        275                 280                 285             


Tyr Pro His Leu Cys Ser Ile Cys Asp Leu Pro Val His Ser Asn Lys 
    290                 295                 300                 


Glu Trp Ser Gln His Ile Asn Gly Ala Ser His Ser Arg Arg Cys Gln 
305                 310                 315                 320 


Leu Leu Leu Glu Ile Tyr Pro Glu Trp Asn Pro Asp Asn Asp Thr Gly 
                325                 330                 335     


His Thr Met Gly Asp Pro Phe Met Leu Gln Gln Ser Thr Asn Pro Ala 
            340                 345                 350         


Pro Gly Ile Leu Gly Pro Pro Pro Pro Ser Phe His Leu Gly Gly Pro 
        355                 360                 365             


Ala Val Gly Pro Arg Gly Asn Leu Gly Ala Gly Asn Gly Asn Leu Gln 
    370                 375                 380                 


Gly Pro Arg His Met Gln Lys Gly Arg Val Glu Thr Ser Arg Val Val 
385                 390                 395                 400 


His Ile Met Asp Phe Gln Arg Gly Lys Asn Leu Arg Tyr Gln Leu Leu 
                405                 410                 415     


Gln Leu Val Glu Pro Phe Gly Val Ile Ser Asn His Leu Ile Leu Asn 
            420                 425                 430         


Lys Ile Asn Glu Ala Phe Ile Glu Met Ala Thr Thr Glu Asp Ala Gln 
        435                 440                 445             


Ala Ala Val Asp Tyr Tyr Thr Thr Thr Pro Ala Leu Val Phe Gly Lys 
    450                 455                 460                 


Pro Val Arg Val His Leu Ser Gln Lys Tyr Lys Arg Ile Lys Lys Pro 
465                 470                 475                 480 


Glu Gly Lys Pro Asp Gln Lys Phe Asp Gln Lys Gln Glu Leu Gly Arg 
                485                 490                 495     


Val Ile His Leu Ser Asn Leu Pro His Ser Gly Tyr Ser Asp Ser Ala 
            500                 505                 510         


Val Leu Lys Leu Ala Glu Pro Tyr Gly Lys Ile Lys Asn Tyr Ile Leu 
        515                 520                 525             


Met Arg Met Lys Ser Gln Ala Phe Ile Glu Met Glu Thr Arg Glu Asp 
    530                 535                 540                 


Ala Met Ala Met Val Asp His Cys Leu Lys Lys Ala Leu Trp Phe Gln 
545                 550                 555                 560 


Gly Arg Cys Val Lys Val Asp Leu Ser Glu Lys Tyr Lys Lys Leu Val 
                565                 570                 575     


Leu Arg Ile Pro Asn Arg Gly Ile Asp Leu Leu Lys Lys Asp Lys Ser 
            580                 585                 590         


Arg Lys Arg Ser Tyr Ser Pro Asp Gly Lys Glu Ser Pro Ser Asp Lys 
        595                 600                 605             


Lys Ser Lys Thr Asp Gly Ser Gln Lys Thr Glu Ser Ser Thr Glu Gly 
    610                 615                 620                 


Lys Glu Gln Glu Glu Lys Ser Gly Glu Asp Gly Glu Lys Asp Thr Lys 
625                 630                 635                 640 


Asp Asp Gln Thr Glu Gln Glu Pro Asn Met Leu Leu Glu Ser Glu Asp 
                645                 650                 655     


Glu Leu Leu Val Asp Glu Glu Glu Ala Ala Ala Leu Leu Glu Ser Gly 
            660                 665                 670         


Ser Ser Val Gly Asp Glu Thr Asp Leu Ala Asn Leu Gly Asp Val Ala 
        675                 680                 685             


Ser Asp Gly Lys Lys Glu Pro Ser Asp Lys Ala Val Lys Lys Asp Gly 
    690                 695                 700                 


Ser Ala Ser Ala Ala Ala Lys Lys Lys Leu Lys Lys Arg Arg Phe Pro 
705                 710                 715                 720 


Gly Ser Met Glu Gly Phe Val Thr Leu Asp Glu Val Gly Asp Glu Glu 
                725                 730                 735     


Asp Ser Glu Leu Gln Lys Leu Arg Lys Ser Gly Met Ala Phe Lys Ser 
            740                 745                 750         


Gly Asp Lys Asn Asp Asp Gly Leu Val Glu Ile Lys Val Asp Lys Ile 
        755                 760                 765             


Glu Glu Leu Asp Gln Glu Asn Glu Ala Ala Leu Glu Asn Gly Ile Lys 
    770                 775                 780                 


Asn Glu Glu Asn Thr Glu Pro Gly Ala Glu Ser Ser Glu Asn Ala Asp 
785                 790                 795                 800 


Asp Pro Asn Lys Asp Thr Ser Glu Asn Ala Asp Gly Gln Ser Asp Glu 
                805                 810                 815     


Asn Lys Asp Asp Tyr Thr Ile Pro Asp Glu Tyr Arg Ile Gly Pro Tyr 
            820                 825                 830         


Gln Pro Asn Val Pro Val Gly Ile Asp Tyr Val Ile Pro Lys Thr Gly 
        835                 840                 845             


Phe Tyr Cys Lys Leu Cys Ser Leu Phe Tyr Thr Asn Glu Glu Val Ala 
    850                 855                 860                 


Lys Asn Thr His Cys Ser Ser Leu Pro His Tyr Gln Lys Leu Lys Lys 
865                 870                 875                 880 


Phe Leu Asn Lys Leu Ala Glu Glu Arg Arg Gln Lys Lys Glu Thr 
                885                 890                 895 


<210>  8371
<211>  847
<212>  PRT
<213>  Homo Sapiens

<400>  8371

Met Ser Lys Ser Phe Gln Gln Ser Ser Leu Ser Arg Asp Ser Gln Gly 
1               5                   10                  15      


His Gly Arg Asp Leu Ser Ala Ala Gly Ile Gly Leu Leu Ala Ala Ala 
            20                  25                  30          


Thr Gln Ser Leu Ser Met Pro Ala Ser Leu Gly Arg Met Asn Gln Gly 
        35                  40                  45              


Thr Ala Arg Leu Ala Ser Leu Met Asn Leu Gly Met Ser Ser Ser Leu 
    50                  55                  60                  


Asn Gln Gln Gly Ala His Ser Ala Leu Ser Ser Ala Ser Thr Ser Ser 
65                  70                  75                  80  


His Asn Leu Gln Ser Ile Phe Asn Ile Gly Ser Arg Gly Pro Leu Pro 
                85                  90                  95      


Leu Ser Ser Gln His Arg Gly Asp Ala Asp Gln Ala Ser Asn Ile Leu 
            100                 105                 110         


Ala Ser Phe Gly Leu Ser Ala Arg Asp Leu Asp Glu Leu Ser Arg Tyr 
        115                 120                 125             


Pro Glu Asp Lys Ile Thr Pro Glu Asn Leu Pro Gln Ile Leu Leu Gln 
    130                 135                 140                 


Leu Lys Arg Arg Arg Thr Glu Glu Gly Pro Thr Leu Ser Tyr Gly Arg 
145                 150                 155                 160 


Asp Gly Arg Ser Ala Thr Arg Glu Pro Pro Tyr Arg Val Pro Arg Asp 
                165                 170                 175     


Asp Trp Glu Glu Lys Arg His Phe Arg Arg Asp Ser Phe Asp Asp Arg 
            180                 185                 190         


Gly Pro Ser Leu Asn Pro Val Leu Asp Tyr Asp His Gly Ser Arg Ser 
        195                 200                 205             


Gln Glu Ser Gly Tyr Tyr Asp Arg Met Asp Tyr Glu Asp Asp Arg Leu 
    210                 215                 220                 


Arg Asp Gly Glu Arg Cys Arg Asp Asp Ser Phe Phe Gly Glu Thr Ser 
225                 230                 235                 240 


His Asn Tyr His Lys Phe Asp Ser Glu Tyr Glu Arg Met Gly Arg Gly 
                245                 250                 255     


Pro Gly Pro Leu Gln Glu Arg Ser Leu Phe Glu Lys Lys Arg Gly Ala 
            260                 265                 270         


Pro Pro Ser Ser Asn Ile Glu Asp Phe His Gly Leu Leu Pro Lys Gly 
        275                 280                 285             


Tyr Pro His Leu Cys Ser Ile Cys Asp Leu Pro Val His Ser Asn Lys 
    290                 295                 300                 


Glu Trp Ser Gln His Ile Asn Gly Ala Ser His Ser Arg Arg Cys Gln 
305                 310                 315                 320 


Leu Leu Leu Glu Ile Tyr Pro Glu Trp Asn Pro Asp Asn Asp Thr Gly 
                325                 330                 335     


His Thr Met Gly Asp Pro Phe Met Leu Gln Gln Ser Thr Asn Pro Ala 
            340                 345                 350         


Pro Gly Ile Leu Gly Pro Pro Pro Pro Ser Phe His Leu Gly Gly Pro 
        355                 360                 365             


Ala Val Gly Pro Arg Gly Asn Leu Gly Ala Gly Asn Gly Asn Leu Gln 
    370                 375                 380                 


Gly Pro Arg His Met Gln Lys Gly Arg Val Glu Thr Ser Arg Val Val 
385                 390                 395                 400 


His Ile Met Asp Phe Gln Arg Gly Lys Asn Leu Arg Tyr Gln Leu Leu 
                405                 410                 415     


Gln Leu Val Glu Pro Phe Gly Val Ile Ser Asn His Leu Ile Leu Asn 
            420                 425                 430         


Lys Ile Asn Glu Ala Phe Ile Glu Met Ala Thr Thr Glu Asp Ala Gln 
        435                 440                 445             


Ala Ala Val Asp Tyr Tyr Thr Thr Thr Pro Ala Leu Val Phe Gly Lys 
    450                 455                 460                 


Pro Val Arg Val His Leu Ser Gln Lys Tyr Lys Arg Ile Lys Lys Pro 
465                 470                 475                 480 


Glu Gly Lys Pro Asp Gln Lys Phe Asp Gln Lys Gln Glu Leu Gly Arg 
                485                 490                 495     


Val Ile His Leu Ser Asn Leu Pro His Ser Gly Tyr Ser Asp Ser Ala 
            500                 505                 510         


Val Leu Lys Leu Ala Glu Pro Tyr Gly Lys Ile Lys Asn Tyr Ile Leu 
        515                 520                 525             


Met Arg Met Lys Ser Gln Ala Phe Ile Glu Met Glu Thr Arg Glu Asp 
    530                 535                 540                 


Ala Met Ala Met Val Asp His Cys Leu Lys Lys Ala Leu Trp Phe Gln 
545                 550                 555                 560 


Gly Arg Cys Val Lys Val Asp Leu Ser Glu Lys Tyr Lys Lys Leu Val 
                565                 570                 575     


Leu Arg Ile Pro Asn Arg Gly Ile Asp Leu Leu Lys Lys Asp Lys Ser 
            580                 585                 590         


Arg Lys Arg Ser Tyr Ser Pro Asp Gly Lys Glu Ser Pro Ser Asp Lys 
        595                 600                 605             


Lys Ser Lys Thr Asp Gly Ser Gln Lys Thr Glu Ser Ser Thr Glu Gly 
    610                 615                 620                 


Lys Glu Gln Glu Glu Lys Ser Gly Glu Asp Gly Glu Lys Asp Thr Lys 
625                 630                 635                 640 


Asp Asp Gln Thr Glu Gln Glu Pro Asn Met Leu Leu Glu Ser Glu Asp 
                645                 650                 655     


Glu Leu Leu Val Asp Glu Glu Glu Ala Ala Ala Leu Leu Glu Ser Gly 
            660                 665                 670         


Ser Ser Val Gly Asp Glu Thr Asp Leu Ala Asn Leu Gly Asp Val Ala 
        675                 680                 685             


Ser Asp Gly Lys Lys Glu Pro Ser Asp Lys Ala Val Lys Lys Asp Gly 
    690                 695                 700                 


Ser Ala Ser Ala Ala Ala Lys Lys Lys Leu Lys Lys Val Asp Lys Ile 
705                 710                 715                 720 


Glu Glu Leu Asp Gln Glu Asn Glu Ala Ala Leu Glu Asn Gly Ile Lys 
                725                 730                 735     


Asn Glu Glu Asn Thr Glu Pro Gly Ala Glu Ser Ser Glu Asn Ala Asp 
            740                 745                 750         


Asp Pro Asn Lys Asp Thr Ser Glu Asn Ala Asp Gly Gln Ser Asp Glu 
        755                 760                 765             


Asn Lys Asp Asp Tyr Thr Ile Pro Asp Glu Tyr Arg Ile Gly Pro Tyr 
    770                 775                 780                 


Gln Pro Asn Val Pro Val Gly Ile Asp Tyr Val Ile Pro Lys Thr Gly 
785                 790                 795                 800 


Phe Tyr Cys Lys Leu Cys Ser Leu Phe Tyr Thr Asn Glu Glu Val Ala 
                805                 810                 815     


Lys Asn Thr His Cys Ser Ser Leu Pro His Tyr Gln Lys Leu Lys Lys 
            820                 825                 830         


Phe Leu Asn Lys Leu Ala Glu Glu Arg Arg Gln Lys Lys Glu Thr 
        835                 840                 845         


<210>  8372
<211>  794
<212>  PRT
<213>  Homo Sapiens

<400>  8372

Met Ser Lys Ser Phe Gln Gln Ser Ser Leu Ser Arg Asp Ser Gln Gly 
1               5                   10                  15      


His Gly Arg Asp Leu Ser Ala Ala Gly Ile Gly Leu Leu Ala Ala Ala 
            20                  25                  30          


Thr Gln Ser Leu Ser Met Pro Ala Ser Leu Gly Arg Met Asn Gln Gly 
        35                  40                  45              


Thr Ala Arg Leu Ala Ser Leu Met Asn Leu Gly Met Ser Ser Ser Leu 
    50                  55                  60                  


Asn Gln Gln Gly Ala His Ser Ala Leu Ser Ser Ala Ser Thr Ser Ser 
65                  70                  75                  80  


His Asn Leu Gln Ser Ile Phe Asn Ile Gly Ser Arg Gly Pro Leu Pro 
                85                  90                  95      


Leu Ser Ser Gln His Arg Gly Asp Ala Asp Gln Ala Ser Asn Ile Leu 
            100                 105                 110         


Ala Ser Phe Gly Leu Ser Ala Arg Asp Leu Asp Glu Leu Ser Arg Tyr 
        115                 120                 125             


Pro Glu Asp Lys Ile Thr Pro Glu Asn Leu Pro Gln Ile Leu Leu Gln 
    130                 135                 140                 


Leu Lys Arg Arg Arg Thr Glu Glu Gly Pro Thr Leu Ser Tyr Gly Arg 
145                 150                 155                 160 


Asp Gly Arg Ser Ala Thr Arg Glu Pro Pro Tyr Arg Val Pro Arg Asp 
                165                 170                 175     


Asp Trp Glu Glu Lys Arg His Phe Arg Arg Asp Ser Phe Asp Asp Arg 
            180                 185                 190         


Gly Pro Ser Leu Asn Pro Val Leu Asp Tyr Asp His Gly Ser Arg Ser 
        195                 200                 205             


Gln Glu Ser Gly Tyr Tyr Asp Arg Met Asp Tyr Glu Asp Asp Arg Leu 
    210                 215                 220                 


Arg Asp Gly Glu Arg Cys Arg Asp Asp Ser Phe Phe Gly Glu Thr Ser 
225                 230                 235                 240 


His Asn Tyr His Lys Phe Asp Ser Glu Tyr Glu Arg Met Gly Arg Gly 
                245                 250                 255     


Pro Gly Pro Leu Gln Glu Arg Ser Leu Phe Glu Lys Lys Arg Gly Ala 
            260                 265                 270         


Pro Pro Ser Ser Asn Ile Glu Asp Phe His Gly Leu Leu Pro Lys Gly 
        275                 280                 285             


Tyr Pro His Leu Cys Ser Ile Cys Asp Leu Pro Val His Ser Asn Lys 
    290                 295                 300                 


Glu Trp Ser Gln His Ile Asn Gly Ala Ser His Ser Arg Arg Cys Gln 
305                 310                 315                 320 


Leu Leu Leu Glu Ile Tyr Pro Glu Trp Asn Pro Asp Asn Asp Thr Gly 
                325                 330                 335     


His Thr Met Gly Asp Pro Phe Met Leu Gln Gln Ser Thr Asn Pro Ala 
            340                 345                 350         


Pro Gly Ile Leu Gly Pro Pro Pro Pro Ser Phe His Leu Gly Gly Pro 
        355                 360                 365             


Ala Val Gly Pro Arg Gly Asn Leu Gly Ala Gly Asn Gly Asn Leu Gln 
    370                 375                 380                 


Gly Pro Arg His Met Gln Lys Gly Arg Val Glu Thr Ser Arg Val Val 
385                 390                 395                 400 


His Ile Met Asp Phe Gln Arg Gly Lys Asn Leu Arg Tyr Gln Leu Leu 
                405                 410                 415     


Gln Leu Val Glu Pro Phe Gly Val Ile Ser Asn His Leu Ile Leu Asn 
            420                 425                 430         


Lys Ile Asn Glu Ala Phe Ile Glu Met Ala Thr Thr Glu Asp Ala Gln 
        435                 440                 445             


Ala Ala Val Asp Tyr Tyr Thr Thr Thr Pro Ala Leu Val Phe Gly Lys 
    450                 455                 460                 


Pro Val Arg Val His Leu Ser Gln Lys Tyr Lys Arg Ile Lys Lys Pro 
465                 470                 475                 480 


Glu Gly Lys Pro Asp Gln Lys Phe Asp Gln Lys Gln Glu Leu Gly Arg 
                485                 490                 495     


Val Ile His Leu Ser Asn Leu Pro His Ser Gly Tyr Ser Asp Ser Ala 
            500                 505                 510         


Val Leu Lys Leu Ala Glu Pro Tyr Gly Lys Ile Lys Asn Tyr Ile Leu 
        515                 520                 525             


Met Arg Met Lys Ser Gln Ala Phe Ile Glu Met Glu Thr Arg Glu Asp 
    530                 535                 540                 


Ala Met Ala Met Val Asp His Cys Leu Lys Lys Ala Leu Trp Phe Gln 
545                 550                 555                 560 


Gly Arg Cys Val Lys Val Asp Leu Ser Glu Lys Tyr Lys Lys Leu Val 
                565                 570                 575     


Leu Arg Ile Pro Asn Arg Gly Ile Asp Leu Leu Lys Lys Asp Lys Ser 
            580                 585                 590         


Arg Lys Arg Ser Tyr Ser Pro Asp Gly Lys Glu Ser Pro Ser Asp Lys 
        595                 600                 605             


Lys Ser Lys Thr Asp Gly Ser Gln Lys Thr Glu Ser Ser Thr Glu Gly 
    610                 615                 620                 


Lys Glu Gln Glu Glu Lys Ser Gly Glu Asp Gly Glu Lys Asp Thr Lys 
625                 630                 635                 640 


Asp Asp Gln Thr Glu Gln Glu Pro Asn Met Leu Leu Glu Ser Glu Asp 
                645                 650                 655     


Glu Leu Leu Val Asp Glu Glu Glu Ala Ala Ala Leu Leu Glu Ser Gly 
            660                 665                 670         


Ser Ser Val Gly Asp Glu Thr Asp Leu Ala Asn Leu Gly Asp Val Ala 
        675                 680                 685             


Ser Asp Gly Lys Lys Glu Pro Ser Asp Lys Ala Val Lys Lys Asp Gly 
    690                 695                 700                 


Ser Ala Ser Ala Ala Ala Lys Lys Lys Leu Lys Lys Val Asp Lys Ile 
705                 710                 715                 720 


Glu Glu Leu Asp Gln Glu Asn Glu Ala Ala Leu Glu Asn Gly Ile Lys 
                725                 730                 735     


Asn Glu Glu Asn Thr Glu Pro Gly Ala Glu Ser Ser Glu Asn Ala Asp 
            740                 745                 750         


Asp Pro Asn Lys Asp Thr Ser Glu Asn Ala Asp Gly Gln Ser Asp Glu 
        755                 760                 765             


Asn Lys Asp Asp Tyr Thr Ile Pro Asp Glu Tyr Arg Ile Gly Pro Tyr 
    770                 775                 780                 


Gln Pro Asn Val Pro Val Glu Ile Ser Glu 
785                 790                 


<210>  8373
<211>  433
<212>  PRT
<213>  Homo Sapiens

<400>  8373

Met Ser Lys Ser Phe Gln Gln Ser Ser Leu Ser Arg Asp Ser Gln Gly 
1               5                   10                  15      


His Gly Arg Asp Leu Ser Ala Ala Gly Ile Gly Leu Leu Ala Ala Ala 
            20                  25                  30          


Thr Gln Ser Leu Ser Met Pro Ala Ser Leu Gly Arg Met Asn Gln Gly 
        35                  40                  45              


Thr Ala Arg Leu Ala Ser Leu Met Asn Leu Gly Met Ser Ser Ser Leu 
    50                  55                  60                  


Asn Gln Gln Gly Ala His Ser Ala Leu Ser Ser Ala Ser Thr Ser Ser 
65                  70                  75                  80  


His Asn Leu Gln Ser Ile Phe Asn Ile Gly Ser Arg Gly Pro Leu Pro 
                85                  90                  95      


Leu Ser Ser Gln His Arg Gly Asp Ala Asp Gln Ala Ser Asn Ile Leu 
            100                 105                 110         


Ala Ser Phe Gly Leu Ser Ala Arg Asp Leu Asp Glu Leu Ser Arg Tyr 
        115                 120                 125             


Pro Glu Asp Lys Ile Thr Pro Glu Asn Leu Pro Gln Ile Leu Leu Gln 
    130                 135                 140                 


Leu Lys Arg Arg Arg Thr Glu Glu Gly Pro Thr Leu Ser Tyr Gly Arg 
145                 150                 155                 160 


Asp Gly Arg Ser Ala Thr Arg Glu Pro Pro Tyr Arg Val Pro Arg Asp 
                165                 170                 175     


Asp Trp Glu Glu Lys Arg His Phe Arg Arg Asp Ser Phe Asp Asp Arg 
            180                 185                 190         


Gly Pro Ser Leu Asn Pro Val Leu Asp Tyr Asp His Gly Ser Arg Ser 
        195                 200                 205             


Gln Glu Ser Gly Tyr Tyr Asp Arg Met Asp Tyr Glu Asp Asp Arg Leu 
    210                 215                 220                 


Arg Asp Gly Glu Arg Cys Arg Asp Asp Ser Phe Phe Gly Glu Thr Ser 
225                 230                 235                 240 


His Asn Tyr His Lys Phe Asp Ser Glu Tyr Glu Arg Met Gly Arg Gly 
                245                 250                 255     


Pro Gly Pro Leu Gln Glu Arg Ser Leu Phe Glu Lys Lys Arg Gly Ala 
            260                 265                 270         


Pro Pro Ser Ser Asn Ile Glu Asp Phe His Gly Leu Leu Pro Lys Gly 
        275                 280                 285             


Tyr Pro His Leu Cys Ser Ile Cys Asp Leu Pro Val His Ser Asn Lys 
    290                 295                 300                 


Glu Trp Ser Gln His Ile Asn Gly Ala Ser His Ser Arg Arg Cys Gln 
305                 310                 315                 320 


Leu Leu Leu Glu Ile Tyr Pro Glu Trp Asn Pro Asp Asn Asp Thr Gly 
                325                 330                 335     


His Thr Met Gly Asp Pro Phe Met Leu Gln Gln Ser Thr Asn Pro Ala 
            340                 345                 350         


Pro Gly Ile Leu Gly Pro Pro Pro Pro Ser Phe His Leu Gly Gly Pro 
        355                 360                 365             


Ala Val Gly Pro Arg Gly Asn Leu Gly Ala Gly Asn Gly Asn Leu Gln 
    370                 375                 380                 


Gly Pro Arg His Met Gln Lys Gly Arg Val Glu Thr Ser Arg Val Val 
385                 390                 395                 400 


His Ile Met Asp Phe Gln Arg Gly Lys Asn Leu Arg Tyr Gln Leu Leu 
                405                 410                 415     


Gln Leu Val Glu Pro Phe Gly Val Ile Ser Asn His Leu Ile Leu Asn 
            420                 425                 430         


Lys 
    


<210>  8374
<211>  847
<212>  PRT
<213>  Homo Sapiens

<400>  8374

Met Ser Lys Ser Phe Gln Gln Ser Ser Leu Ser Arg Asp Ser Gln Gly 
1               5                   10                  15      


His Gly Arg Asp Leu Ser Ala Ala Gly Ile Gly Leu Leu Ala Ala Ala 
            20                  25                  30          


Thr Gln Ser Leu Ser Met Pro Ala Ser Leu Gly Arg Met Asn Gln Gly 
        35                  40                  45              


Thr Ala Arg Leu Ala Ser Leu Met Asn Leu Gly Met Ser Ser Ser Leu 
    50                  55                  60                  


Asn Gln Gln Gly Ala His Ser Ala Leu Ser Ser Ala Ser Thr Ser Ser 
65                  70                  75                  80  


His Asn Leu Gln Ser Ile Phe Asn Ile Gly Ser Arg Gly Pro Leu Pro 
                85                  90                  95      


Leu Ser Ser Gln His Arg Gly Asp Ala Asp Gln Ala Ser Asn Ile Leu 
            100                 105                 110         


Ala Ser Phe Gly Leu Ser Ala Arg Asp Leu Asp Glu Leu Ser Arg Tyr 
        115                 120                 125             


Pro Glu Asp Lys Ile Thr Pro Glu Asn Leu Pro Gln Ile Leu Leu Gln 
    130                 135                 140                 


Leu Lys Arg Arg Arg Thr Glu Glu Gly Pro Thr Leu Ser Tyr Gly Arg 
145                 150                 155                 160 


Asp Gly Arg Ser Ala Thr Arg Glu Pro Pro Tyr Arg Val Pro Arg Asp 
                165                 170                 175     


Asp Trp Glu Glu Lys Arg His Phe Arg Arg Asp Ser Phe Asp Asp Arg 
            180                 185                 190         


Gly Pro Ser Leu Asn Pro Val Leu Asp Tyr Asp His Gly Ser Arg Ser 
        195                 200                 205             


Gln Glu Ser Gly Tyr Tyr Asp Arg Met Asp Tyr Glu Asp Asp Arg Leu 
    210                 215                 220                 


Arg Asp Gly Glu Arg Cys Arg Asp Asp Ser Phe Phe Gly Glu Thr Ser 
225                 230                 235                 240 


His Asn Tyr His Lys Phe Asp Ser Glu Tyr Glu Arg Met Gly Arg Gly 
                245                 250                 255     


Pro Gly Pro Leu Gln Glu Arg Ser Leu Phe Glu Lys Lys Arg Gly Ala 
            260                 265                 270         


Pro Pro Ser Ser Asn Ile Glu Asp Phe His Gly Leu Leu Pro Lys Gly 
        275                 280                 285             


Tyr Pro His Leu Cys Ser Ile Cys Asp Leu Pro Val His Ser Asn Lys 
    290                 295                 300                 


Glu Trp Ser Gln His Ile Asn Gly Ala Ser His Ser Arg Arg Cys Gln 
305                 310                 315                 320 


Leu Leu Leu Glu Ile Tyr Pro Glu Trp Asn Pro Asp Asn Asp Thr Gly 
                325                 330                 335     


His Thr Met Gly Asp Pro Phe Met Leu Gln Gln Ser Thr Asn Pro Ala 
            340                 345                 350         


Pro Gly Ile Leu Gly Pro Pro Pro Pro Ser Phe His Leu Gly Gly Pro 
        355                 360                 365             


Ala Val Gly Pro Arg Gly Asn Leu Gly Ala Gly Asn Gly Asn Leu Gln 
    370                 375                 380                 


Gly Pro Arg His Met Gln Lys Gly Arg Val Glu Thr Ser Arg Val Val 
385                 390                 395                 400 


His Ile Met Asp Phe Gln Arg Gly Lys Asn Leu Arg Tyr Gln Leu Leu 
                405                 410                 415     


Gln Leu Val Glu Pro Phe Gly Val Ile Ser Asn His Leu Ile Leu Asn 
            420                 425                 430         


Lys Ile Asn Glu Ala Phe Ile Glu Met Ala Thr Thr Glu Asp Ala Gln 
        435                 440                 445             


Ala Ala Val Asp Tyr Tyr Thr Thr Thr Pro Ala Leu Val Phe Gly Lys 
    450                 455                 460                 


Pro Val Arg Val His Leu Ser Gln Lys Tyr Lys Arg Ile Lys Lys Pro 
465                 470                 475                 480 


Glu Gly Lys Pro Asp Gln Lys Phe Asp Gln Lys Gln Glu Leu Gly Arg 
                485                 490                 495     


Val Ile His Leu Ser Asn Leu Pro His Ser Gly Tyr Ser Asp Ser Ala 
            500                 505                 510         


Val Leu Lys Leu Ala Glu Pro Tyr Gly Lys Ile Lys Asn Tyr Ile Leu 
        515                 520                 525             


Met Arg Met Lys Ser Gln Ala Phe Ile Glu Met Glu Thr Arg Glu Asp 
    530                 535                 540                 


Ala Met Ala Met Val Asp His Cys Leu Lys Lys Ala Leu Trp Phe Gln 
545                 550                 555                 560 


Gly Arg Cys Val Lys Val Asp Leu Ser Glu Lys Tyr Lys Lys Leu Val 
                565                 570                 575     


Leu Arg Ile Pro Asn Arg Gly Ile Asp Leu Leu Lys Lys Asp Lys Ser 
            580                 585                 590         


Arg Lys Arg Ser Tyr Ser Pro Asp Gly Lys Glu Ser Pro Ser Asp Lys 
        595                 600                 605             


Lys Ser Lys Thr Asp Gly Ser Gln Lys Thr Glu Ser Ser Thr Glu Gly 
    610                 615                 620                 


Lys Glu Gln Glu Glu Lys Ser Gly Glu Asp Gly Glu Lys Asp Thr Lys 
625                 630                 635                 640 


Asp Asp Gln Thr Glu Gln Glu Pro Asn Met Leu Leu Glu Ser Glu Asp 
                645                 650                 655     


Glu Leu Leu Val Asp Glu Glu Glu Ala Ala Ala Leu Leu Glu Ser Gly 
            660                 665                 670         


Ser Ser Val Gly Asp Glu Thr Asp Leu Ala Asn Leu Gly Asp Val Ala 
        675                 680                 685             


Ser Asp Gly Lys Lys Glu Pro Ser Asp Lys Ala Val Lys Lys Asp Gly 
    690                 695                 700                 


Ser Ala Ser Ala Ala Ala Lys Lys Lys Leu Lys Lys Val Asp Lys Ile 
705                 710                 715                 720 


Glu Glu Leu Asp Gln Glu Asn Glu Ala Ala Leu Glu Asn Gly Ile Lys 
                725                 730                 735     


Asn Glu Glu Asn Thr Glu Pro Gly Ala Glu Ser Ser Glu Asn Ala Asp 
            740                 745                 750         


Asp Pro Asn Lys Asp Thr Ser Glu Asn Ala Asp Gly Gln Ser Asp Glu 
        755                 760                 765             


Asn Lys Asp Asp Tyr Thr Ile Pro Asp Glu Tyr Arg Ile Gly Pro Tyr 
    770                 775                 780                 


Gln Pro Asn Val Pro Val Gly Ile Asp Tyr Val Ile Pro Lys Thr Gly 
785                 790                 795                 800 


Phe Tyr Cys Lys Leu Cys Ser Leu Phe Tyr Thr Asn Glu Glu Val Ala 
                805                 810                 815     


Lys Asn Thr His Cys Ser Ser Leu Pro His Tyr Gln Lys Leu Lys Lys 
            820                 825                 830         


Phe Leu Asn Lys Leu Ala Glu Glu Arg Arg Gln Lys Lys Glu Thr 
        835                 840                 845         


<210>  8375
<211>  334
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8375

Xaa Glu Arg Cys Arg Asp Asp Ser Phe Phe Gly Glu Thr Ser His Asn 
1               5                   10                  15      


Tyr His Lys Phe Asp Ser Glu Tyr Glu Arg Met Gly Arg Gly Pro Gly 
            20                  25                  30          


Pro Leu Gln Glu Arg Ser Leu Phe Glu Lys Lys Arg Gly Ala Pro Pro 
        35                  40                  45              


Ser Ser Asn Ile Glu Asp Phe His Gly Leu Leu Pro Lys Gly Tyr Pro 
    50                  55                  60                  


His Leu Cys Ser Ile Cys Asp Leu Pro Val His Ser Asn Lys Glu Trp 
65                  70                  75                  80  


Ser Gln His Ile Asn Gly Ala Ser His Ser Arg Arg Cys Gln Leu Leu 
                85                  90                  95      


Leu Glu Met Gly Asp Pro Phe Met Leu Gln Gln Ser Thr Asn Pro Ala 
            100                 105                 110         


Pro Gly Ile Leu Gly Pro Pro Pro Pro Ser Phe His Leu Gly Gly Pro 
        115                 120                 125             


Ala Val Gly Pro Arg Gly Asn Leu Gly Ala Gly Asn Gly Asn Leu Gln 
    130                 135                 140                 


Gly Pro Arg His Met Gln Lys Gly Arg Val Glu Thr Ser Arg Val Val 
145                 150                 155                 160 


His Ile Met Asp Phe Gln Arg Gly Lys Asn Leu Arg Tyr Gln Leu Leu 
                165                 170                 175     


Gln Leu Val Glu Pro Phe Gly Val Ile Ser Asn His Leu Ile Leu Asn 
            180                 185                 190         


Lys Ile Asn Glu Ala Phe Ile Glu Met Ala Thr Thr Glu Asp Ala Gln 
        195                 200                 205             


Ala Ala Val Asp Tyr Tyr Thr Thr Thr Pro Ala Leu Val Phe Gly Lys 
    210                 215                 220                 


Pro Val Arg Val His Leu Ser Gln Lys Tyr Lys Arg Ile Lys Lys Pro 
225                 230                 235                 240 


Glu Gly Lys Pro Asp Gln Lys Phe Asp Gln Lys Gln Glu Leu Gly Arg 
                245                 250                 255     


Val Ile His Leu Ser Asn Leu Pro His Ser Gly Tyr Ser Asp Ser Ala 
            260                 265                 270         


Val Leu Lys Leu Ala Glu Pro Tyr Gly Lys Ile Lys Asn Tyr Ile Leu 
        275                 280                 285             


Met Arg Met Lys Ser Gln Ala Phe Ile Glu Met Glu Thr Arg Glu Asp 
    290                 295                 300                 


Ala Met Ala Met Val Asp His Cys Leu Lys Lys Ala Leu Trp Phe Gln 
305                 310                 315                 320 


Gly Arg Cys Val Lys Val Asp Leu Ser Glu Lys Tyr Lys Lys 
                325                 330                 


<210>  8376
<211>  235
<212>  PRT
<213>  Homo Sapiens

<400>  8376

Ala Ile Gln Ile Ser Gln Gln Thr Pro Tyr Trp His Cys Arg Leu Leu 
1               5                   10                  15      


Phe Gln Leu Ala Gln Leu His Thr Leu Glu Lys Asp Leu Val Ser Ala 
            20                  25                  30          


Cys Asp Leu Leu Gly Val Gly Ala Glu Tyr Ala Arg Val Val Gly Ser 
        35                  40                  45              


Glu Tyr Thr Arg Ala Leu Phe Leu Leu Ser Lys Gly Met Leu Leu Leu 
    50                  55                  60                  


Met Glu Arg Lys Leu Gln Glu Val His Pro Leu Leu Thr Leu Cys Gly 
65                  70                  75                  80  


Gln Ile Val Glu Asn Trp Gln Gly Asn Pro Ile Gln Lys Glu Ser Leu 
                85                  90                  95      


Arg Val Phe Phe Leu Val Leu Gln Val Thr His Tyr Leu Asp Ala Gly 
            100                 105                 110         


Gln Val Lys Ser Val Lys Pro Cys Leu Lys Gln Leu Gln Gln Cys Ile 
        115                 120                 125             


Gln Thr Ile Ser Thr Leu His Asp Asp Glu Ile Leu Pro Ser Asn Pro 
    130                 135                 140                 


Ala Asp Leu Phe His Trp Leu Pro Lys Glu His Met Cys Val Leu Val 
145                 150                 155                 160 


Tyr Leu Val Thr Val Met His Ser Met Gln Ala Gly Tyr Leu Glu Lys 
                165                 170                 175     


Ala Gln Lys Tyr Thr Asp Lys Ala Leu Met Gln Leu Glu Lys Leu Lys 
            180                 185                 190         


Ser Lys Ser Val Leu Asp Cys Ser Pro Ile Leu Ser Ser Phe Gln Val 
        195                 200                 205             


Ile Leu Leu Glu His Ile Ile Met Cys Arg Leu Val Thr Gly His Lys 
    210                 215                 220                 


Ala Thr Ala Leu Gln Glu Ile Ser Gln Val Cys 
225                 230                 235 


<210>  8377
<211>  183
<212>  PRT
<213>  Homo Sapiens

<400>  8377

Lys Ile Arg Leu Cys Val His Cys Leu Gln Ala Val Phe Pro Phe Lys 
1               5                   10                  15      


Pro Pro Gln Arg Ile Glu Ala Arg Thr His Leu Gln Leu Gly Ser Val 
            20                  25                  30          


Leu Tyr His His Thr Lys Asn Ser Glu Gln Ala Arg Ser His Leu Glu 
        35                  40                  45              


Lys Ala Asn Ser Val Asp Ala Ala Lys Pro Leu Leu Arg Lys Ala Ile 
    50                  55                  60                  


Gln Ile Ser Gln Gln Thr Pro Tyr Trp His Cys Arg Leu Leu Phe Gln 
65                  70                  75                  80  


Leu Ala Gln Leu His Thr Leu Glu Lys Asp Leu Val Ser Ala Cys Asp 
                85                  90                  95      


Leu Leu Gly Val Gly Ala Glu Tyr Ala Arg Val Val Gly Ser Glu Tyr 
            100                 105                 110         


Thr Arg Ala Leu Phe Leu Leu Ser Lys Gly Met Leu Leu Leu Met Glu 
        115                 120                 125             


Arg Lys Leu Gln Glu Val His Pro Leu Leu Thr Leu Cys Gly Gln Ile 
    130                 135                 140                 


Val Glu Asn Trp Gln Gly Asn Pro Ile Gln Lys Glu Ser Leu Arg Val 
145                 150                 155                 160 


Phe Phe Leu Val Leu Gln Val Thr His Tyr Leu Asp Ala Gly Gln Val 
                165                 170                 175     


Lys Ser Val Lys Pro Cys Leu 
            180             


<210>  8378
<211>  613
<212>  PRT
<213>  Homo Sapiens

<400>  8378

Met Ala Ala Gln Ala Ala Ala Ala Ala Gln Ala Ala Ala Ala Gln Ala 
1               5                   10                  15      


Ala Gln Ala Glu Ala Ala Asp Ser Trp Tyr Leu Ala Leu Leu Gly Phe 
            20                  25                  30          


Ala Glu His Phe Arg Thr Ser Ser Pro Pro Lys Ile Arg Leu Cys Val 
        35                  40                  45              


His Cys Leu Gln Ala Val Phe Pro Phe Lys Pro Pro Gln Arg Ile Glu 
    50                  55                  60                  


Ala Arg Thr His Leu Gln Leu Gly Ser Val Leu Tyr His His Thr Lys 
65                  70                  75                  80  


Asn Ser Glu Gln Ala Arg Ser His Leu Glu Lys Ala Trp Leu Ile Ser 
                85                  90                  95      


Gln Gln Ile Pro Gln Phe Glu Asp Val Lys Phe Glu Ala Ala Ser Leu 
            100                 105                 110         


Leu Ser Glu Leu Tyr Cys Gln Glu Asn Ser Val Asp Ala Ala Lys Pro 
        115                 120                 125             


Leu Leu Arg Lys Ala Ile Gln Ile Ser Gln Gln Thr Pro Tyr Trp His 
    130                 135                 140                 


Cys Arg Leu Leu Phe Gln Leu Ala Gln Leu His Thr Leu Glu Lys Asp 
145                 150                 155                 160 


Leu Val Ser Ala Cys Asp Leu Leu Gly Val Gly Ala Glu Tyr Ala Arg 
                165                 170                 175     


Val Val Gly Ser Glu Tyr Thr Arg Ala Leu Phe Leu Leu Ser Lys Gly 
            180                 185                 190         


Met Leu Leu Leu Met Glu Arg Lys Leu Gln Glu Val His Pro Leu Leu 
        195                 200                 205             


Thr Leu Cys Gly Gln Ile Val Glu Asn Trp Gln Gly Asn Pro Ile Gln 
    210                 215                 220                 


Lys Glu Ser Leu Arg Val Phe Phe Leu Val Leu Gln Val Thr His Tyr 
225                 230                 235                 240 


Leu Asp Ala Gly Gln Val Lys Ser Val Lys Pro Cys Leu Lys Gln Leu 
                245                 250                 255     


Gln Gln Cys Ile Gln Thr Ile Ser Thr Leu His Asp Asp Glu Ile Leu 
            260                 265                 270         


Pro Ser Asn Pro Ala Asp Leu Phe His Trp Leu Pro Lys Glu His Met 
        275                 280                 285             


Cys Val Leu Val Tyr Leu Val Thr Val Met His Ser Met Gln Ala Gly 
    290                 295                 300                 


Tyr Leu Glu Lys Ala Gln Lys Tyr Thr Asp Lys Ala Leu Met Gln Leu 
305                 310                 315                 320 


Glu Lys Leu Lys Met Leu Asp Cys Ser Pro Ile Leu Ser Ser Phe Gln 
                325                 330                 335     


Val Ile Leu Leu Glu His Ile Ile Met Cys Arg Leu Val Thr Gly His 
            340                 345                 350         


Lys Ala Thr Ala Leu Gln Glu Ile Ser Gln Val Cys Gln Leu Cys Gln 
        355                 360                 365             


Gln Ser Pro Arg Leu Phe Ser Asn His Ala Ala Gln Leu His Thr Leu 
    370                 375                 380                 


Leu Gly Leu Tyr Cys Val Ser Val Asn Cys Met Asp Asn Ala Glu Ala 
385                 390                 395                 400 


Gln Phe Thr Thr Ala Leu Arg Leu Thr Asn His Gln Glu Leu Trp Ala 
                405                 410                 415     


Phe Ile Val Thr Asn Leu Ala Ser Val Tyr Ile Arg Glu Gly Asn Arg 
            420                 425                 430         


His Gln Glu Val Leu Tyr Ser Leu Leu Glu Arg Ile Asn Pro Asp His 
        435                 440                 445             


Ser Phe Pro Val Ser Ser His Cys Leu Arg Ala Ala Ala Phe Tyr Val 
    450                 455                 460                 


Arg Gly Leu Phe Ser Phe Phe Gln Gly Arg Tyr Asn Glu Ala Lys Arg 
465                 470                 475                 480 


Phe Leu Arg Glu Thr Leu Lys Met Ser Asn Ala Glu Asp Leu Asn Arg 
                485                 490                 495     


Leu Thr Ala Cys Ser Leu Val Leu Leu Gly His Ile Phe Tyr Val Leu 
            500                 505                 510         


Gly Asn His Arg Glu Ser Asn Asn Met Val Val Pro Ala Met Gln Leu 
        515                 520                 525             


Ala Ser Lys Ile Pro Asp Met Ser Val Gln Leu Trp Ser Ser Ala Leu 
    530                 535                 540                 


Leu Arg Asp Leu Asn Lys Ala Cys Gly Asn Ala Met Asp Ala His Glu 
545                 550                 555                 560 


Ala Ala Gln Met His Gln Asn Phe Ser Gln Gln Leu Leu Gln Asp His 
                565                 570                 575     


Ile Glu Ala Cys Ser Leu Pro Glu His Asn Leu Ile Thr Trp Thr Asp 
            580                 585                 590         


Gly Pro Pro Pro Val Gln Phe Gln Ala Gln Asn Gly Pro Asn Thr Ser 
        595                 600                 605             


Leu Ala Ser Leu Leu 
    610             


<210>  8379
<211>  202
<212>  PRT
<213>  Homo Sapiens

<400>  8379

Ala Gly Ala Gly Gly Gly Ala Ala Ala Val Ala Ala Gly Gly Val Val 
1               5                   10                  15      


Thr Thr Thr Ala Ser Gly Lys Arg Ile Arg Lys Asn His Ala Cys Glu 
            20                  25                  30          


Met Cys Gly Lys Ala Phe Arg Asp Val Tyr His Leu Asn Arg His Lys 
        35                  40                  45              


Leu Ser His Ser Asp Glu Lys Pro Tyr Gln Cys Pro Val Cys Gln Gln 
    50                  55                  60                  


Arg Phe Lys Arg Lys Asp Arg Met Ser Tyr His Val Arg Ser His Asp 
65                  70                  75                  80  


Gly Ala Val His Lys Pro Tyr Asn Cys Ser His Cys Gly Lys Ser Phe 
                85                  90                  95      


Ser Arg Pro Asp His Leu Asn Ser His Val Arg Gln Val His Ser Thr 
            100                 105                 110         


Glu Arg Pro Phe Lys Cys Glu Lys Cys Glu Ala Ala Phe Ala Thr Lys 
        115                 120                 125             


Asp Arg Leu Arg Ala His Thr Val Arg His Glu Glu Lys Val Pro Cys 
    130                 135                 140                 


His Val Cys Gly Lys Met Leu Ser Ser Ala Tyr Ile Ser Asp His Met 
145                 150                 155                 160 


Lys Val His Ser Gln Gly Pro His His Val Cys Glu Leu Cys Asn Lys 
                165                 170                 175     


Gly Thr Cys Arg Gly Leu Pro Gly Gly Pro Gly Ala Glu Gly Gly Arg 
            180                 185                 190         


Leu Ala Arg Arg Leu Ala Thr Asp Thr Gly 
        195                 200         


<210>  8380
<211>  454
<212>  PRT
<213>  Homo Sapiens

<400>  8380

Met Asp Pro Ser Asn Trp Ser Ser Phe Ile Phe Gln Gly His Ala Gln 
1               5                   10                  15      


Asn Pro Leu Gln Val Gly Ala Glu Leu Gln Ser Arg Phe Phe Ala Ser 
            20                  25                  30          


Gln Gly Cys Ala Gln Ser Pro Phe Gln Ala Ala Pro Ala Pro Pro Pro 
        35                  40                  45              


Thr Pro Gln Ala Pro Ala Ala Glu Pro Leu Gln Val Asp Leu Leu Pro 
    50                  55                  60                  


Val Leu Ala Ala Ala Gln Glu Ser Ala Ala Ala Ala Ala Ala Ala Ala 
65                  70                  75                  80  


Ala Ala Ala Ala Ala Val Ala Ala Ala Pro Pro Ala Pro Ala Ala Ala 
                85                  90                  95      


Ser Thr Val Asp Thr Ala Ala Leu Lys Gln Pro Pro Ala Pro Pro Pro 
            100                 105                 110         


Pro Pro Pro Pro Val Ser Ala Pro Ala Ala Glu Ala Ala Pro Pro Ala 
        115                 120                 125             


Ser Ala Ala Thr Ile Ala Ala Ala Ala Ala Thr Ala Val Val Ala Pro 
    130                 135                 140                 


Thr Ser Thr Val Ala Val Ala Pro Val Ala Ser Ala Leu Glu Lys Lys 
145                 150                 155                 160 


Thr Lys Ser Lys Gly Pro Tyr Ile Cys Ala Leu Cys Ala Lys Glu Phe 
                165                 170                 175     


Lys Asn Gly Tyr Asn Leu Arg Arg His Glu Ala Ile His Thr Gly Ala 
            180                 185                 190         


Lys Ala Gly Arg Val Pro Ser Gly Ala Met Lys Met Pro Thr Met Val 
        195                 200                 205             


Pro Leu Ser Leu Leu Ser Val Pro Gln Leu Ser Gly Ala Gly Gly Gly 
    210                 215                 220                 


Gly Gly Glu Ala Gly Ala Gly Gly Gly Ala Ala Ala Val Ala Ala Gly 
225                 230                 235                 240 


Gly Val Val Thr Thr Thr Ala Ser Gly Lys Arg Ile Arg Lys Asn His 
                245                 250                 255     


Ala Cys Glu Met Cys Gly Lys Ala Phe Arg Asp Val Tyr His Leu Asn 
            260                 265                 270         


Arg His Lys Leu Ser His Ser Asp Glu Lys Pro Tyr Gln Cys Pro Val 
        275                 280                 285             


Cys Gln Gln Arg Phe Lys Arg Lys Asp Arg Met Ser Tyr His Val Arg 
    290                 295                 300                 


Ser His Asp Gly Ala Val His Lys Pro Tyr Asn Cys Ser His Cys Gly 
305                 310                 315                 320 


Lys Ser Phe Ser Arg Pro Asp His Leu Asn Ser His Val Arg Gln Val 
                325                 330                 335     


His Ser Thr Glu Arg Pro Phe Lys Cys Glu Lys Cys Glu Ala Ala Phe 
            340                 345                 350         


Ala Thr Lys Asp Arg Leu Arg Ala His Thr Val Arg His Glu Glu Lys 
        355                 360                 365             


Val Pro Cys His Val Cys Gly Lys Met Leu Ser Ser Ala Tyr Ile Ser 
    370                 375                 380                 


Asp His Met Lys Val His Ser Gln Gly Pro His His Val Cys Glu Leu 
385                 390                 395                 400 


Cys Asn Lys Gly Thr Gly Glu Val Cys Pro Met Ala Ala Ala Ala Ala 
                405                 410                 415     


Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Ala Ala Pro Pro Thr Ala 
            420                 425                 430         


Val Gly Ser Leu Ser Gly Ala Glu Gly Val Pro Val Ser Ser Gln Pro 
        435                 440                 445             


Leu Pro Ser Gln Pro Trp 
    450                 


<210>  8381
<211>  184
<212>  PRT
<213>  Homo Sapiens

<400>  8381

Met Phe Pro Val Phe Pro Cys Thr Leu Leu Ala Pro Pro Phe Pro Val 
1               5                   10                  15      


Leu Gly Leu Asp Ser Arg Gly Val Gly Gly Leu Met Asn Ser Phe Pro 
            20                  25                  30          


Pro Pro Gln Gly His Ala Gln Asn Pro Leu Gln Val Gly Ala Glu Leu 
        35                  40                  45              


Gln Ser Arg Phe Phe Ala Ser Gln Gly Cys Ala Gln Ser Pro Phe Gln 
    50                  55                  60                  


Ala Ala Pro Ala Pro Pro Pro Thr Pro Gln Ala Pro Ala Ala Glu Pro 
65                  70                  75                  80  


Leu Gln Val Asp Leu Leu Pro Val Leu Ala Ala Ala Gln Asp Gly Gly 
                85                  90                  95      


Ser Gly Ser Ser Gly Ser Ser Ser Ser Pro Ser His Ser Cys Gly Leu 
            100                 105                 110         


Pro Leu Gly Gly Gly Gly Gly Ala Cys Glu Leu Ser Ala Thr Ser Leu 
        115                 120                 125             


Pro Thr Leu Val Ser Ser Lys Leu Val Ala Gly Glu Arg Gly Glu Trp 
    130                 135                 140                 


Ser Arg Val Pro Trp Tyr Lys Leu Leu Ser Pro Leu Phe Ser His Gln 
145                 150                 155                 160 


Leu Leu Phe Pro Tyr Gln Pro Arg Ser Leu Gln Lys Glu Arg Arg Lys 
                165                 170                 175     


Lys Cys Phe Leu Arg Gly Ile Arg 
            180                 


<210>  8382
<211>  186
<212>  PRT
<213>  Homo Sapiens

<400>  8382

Met Phe Pro Val Phe Pro Cys Thr Leu Leu Ala Pro Pro Phe Pro Val 
1               5                   10                  15      


Leu Gly Leu Asp Ser Arg Gly Val Gly Gly Leu Met Asn Ser Phe Pro 
            20                  25                  30          


Pro Pro Gln Gly His Ala Gln Asn Pro Leu Gln Val Gly Ala Glu Leu 
        35                  40                  45              


Gln Ser Arg Phe Phe Ala Ser Gln Gly Cys Ala Gln Ser Pro Phe Gln 
    50                  55                  60                  


Ala Ala Pro Ala Pro Pro Pro Thr Pro Gln Ala Pro Ala Ala Glu Pro 
65                  70                  75                  80  


Leu Gln Val Asp Leu Leu Pro Val Leu Ala Ala Ala Gln Asp Gly Ser 
                85                  90                  95      


Gly Gly Ser Gly Ser Ser Gly Ser Ser Ser Ser Pro Ser His Ser Cys 
            100                 105                 110         


Gly Leu Pro Leu Gly Gly Gly Gly Gly Ala Cys Glu Leu Ser Ala Thr 
        115                 120                 125             


Ser Leu Pro Thr Leu Val Ser Ser Lys Leu Val Ala Gly Glu Arg Gly 
    130                 135                 140                 


Glu Trp Ser Arg Val Pro Trp Tyr Lys Leu Leu Ser Pro Leu Phe Ser 
145                 150                 155                 160 


His Gln Leu Leu Phe Pro Tyr Gln Pro Arg Ser Leu Gln Lys Glu Arg 
                165                 170                 175     


Arg Lys Lys Cys Phe Leu Arg Gly Ile Arg 
            180                 185     


<210>  8383
<211>  493
<212>  PRT
<213>  Homo Sapiens

<400>  8383

Met Phe Pro Val Phe Pro Cys Thr Leu Leu Ala Pro Pro Phe Pro Val 
1               5                   10                  15      


Leu Gly Leu Asp Ser Arg Gly Val Gly Gly Leu Met Asn Ser Phe Pro 
            20                  25                  30          


Pro Pro Gln Gly His Ala Gln Asn Pro Leu Gln Val Gly Ala Glu Leu 
        35                  40                  45              


Gln Ser Arg Phe Phe Ala Ser Gln Gly Cys Ala Gln Ser Pro Phe Gln 
    50                  55                  60                  


Ala Ala Pro Ala Pro Pro Pro Thr Pro Gln Ala Pro Ala Ala Glu Pro 
65                  70                  75                  80  


Leu Gln Val Asp Leu Leu Pro Val Leu Ala Ala Ala Gln Glu Ser Ala 
                85                  90                  95      


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Ala Ala Ala 
            100                 105                 110         


Pro Pro Ala Pro Ala Ala Ala Ser Thr Val Asp Thr Ala Ala Leu Lys 
        115                 120                 125             


Gln Pro Pro Ala Pro Pro Pro Pro Pro Pro Pro Val Ser Ala Pro Ala 
    130                 135                 140                 


Ala Glu Ala Ala Pro Pro Ala Ser Ala Ala Thr Ile Ala Ala Ala Ala 
145                 150                 155                 160 


Ala Thr Ala Val Val Ala Pro Thr Ser Thr Val Ala Val Ala Pro Val 
                165                 170                 175     


Ala Ser Ala Leu Glu Lys Lys Thr Lys Ser Lys Gly Pro Tyr Ile Cys 
            180                 185                 190         


Ala Leu Cys Ala Lys Glu Phe Lys Asn Gly Tyr Asn Leu Arg Arg His 
        195                 200                 205             


Glu Ala Ile His Thr Gly Ala Lys Ala Gly Arg Val Pro Ser Gly Ala 
    210                 215                 220                 


Met Lys Met Pro Thr Met Val Pro Leu Ser Leu Leu Ser Val Pro Gln 
225                 230                 235                 240 


Leu Ser Gly Ala Gly Gly Gly Gly Gly Glu Ala Gly Ala Gly Gly Gly 
                245                 250                 255     


Ala Ala Ala Val Ala Ala Gly Gly Val Val Thr Thr Thr Ala Ser Gly 
            260                 265                 270         


Lys Arg Ile Arg Lys Asn His Ala Cys Glu Met Cys Gly Lys Ala Phe 
        275                 280                 285             


Arg Asp Val Tyr His Leu Asn Arg His Lys Leu Ser His Ser Asp Glu 
    290                 295                 300                 


Lys Pro Tyr Gln Cys Pro Val Cys Gln Gln Arg Phe Lys Arg Lys Asp 
305                 310                 315                 320 


Arg Met Ser Tyr His Val Arg Ser His Asp Gly Ala Val His Lys Pro 
                325                 330                 335     


Tyr Asn Cys Ser His Cys Gly Lys Ser Phe Ser Arg Pro Asp His Leu 
            340                 345                 350         


Asn Ser His Val Arg Gln Val His Ser Thr Glu Arg Pro Phe Lys Cys 
        355                 360                 365             


Glu Lys Cys Glu Ala Ala Phe Ala Thr Lys Asp Arg Leu Arg Ala His 
    370                 375                 380                 


Thr Val Arg His Glu Glu Lys Val Pro Cys His Val Cys Gly Lys Met 
385                 390                 395                 400 


Leu Ser Ser Ala Tyr Ile Ser Asp His Met Lys Val His Ser Gln Gly 
                405                 410                 415     


Pro His His Val Cys Glu Leu Cys Asn Lys Gly Phe Thr Thr Ala Ala 
            420                 425                 430         


Tyr Leu Arg Ile His Ala Val Lys Asp His Gly Leu Gln Ala Pro Arg 
        435                 440                 445             


Ala Asp Arg Ile Leu Cys Lys Leu Cys Ser Val His Cys Lys Thr Pro 
    450                 455                 460                 


Ala Gln Leu Ala Gly His Met Gln Thr His Leu Gly Gly Ala Ala Pro 
465                 470                 475                 480 


Pro Val Pro Gly Asp Ala Pro Gln Pro Gln Pro Thr Cys 
                485                 490             


<210>  8384
<211>  477
<212>  PRT
<213>  Homo Sapiens

<400>  8384

Met Phe Pro Val Phe Pro Cys Thr Leu Leu Ala Pro Pro Phe Pro Val 
1               5                   10                  15      


Leu Gly Leu Asp Ser Arg Gly Val Gly Gly Leu Met Asn Ser Phe Pro 
            20                  25                  30          


Pro Pro Gln Gly His Ala Gln Asn Pro Leu Gln Val Gly Ala Glu Leu 
        35                  40                  45              


Gln Ser Arg Phe Phe Ala Ser Gln Gly Cys Ala Gln Ser Pro Phe Gln 
    50                  55                  60                  


Ala Ala Pro Ala Pro Pro Pro Thr Pro Gln Ala Pro Ala Ala Glu Pro 
65                  70                  75                  80  


Leu Gln Val Asp Leu Leu Pro Val Leu Ala Ala Ala Gln Glu Ser Ala 
                85                  90                  95      


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Ala Ala Ala 
            100                 105                 110         


Pro Pro Ala Pro Ala Ala Ala Ser Thr Val Asp Thr Ala Ala Leu Lys 
        115                 120                 125             


Gln Pro Pro Ala Pro Pro Pro Pro Pro Pro Pro Val Ser Ala Pro Ala 
    130                 135                 140                 


Ala Glu Ala Ala Pro Pro Ala Ser Ala Ala Thr Ile Ala Ala Ala Ala 
145                 150                 155                 160 


Ala Thr Ala Val Val Ala Pro Thr Ser Thr Val Ala Val Ala Pro Val 
                165                 170                 175     


Ala Ser Ala Leu Glu Lys Lys Thr Lys Ser Lys Gly Pro Tyr Ile Cys 
            180                 185                 190         


Ala Leu Cys Ala Lys Glu Phe Lys Asn Gly Tyr Asn Leu Arg Arg His 
        195                 200                 205             


Glu Ala Ile His Thr Gly Ala Lys Ala Gly Arg Val Pro Ser Gly Ala 
    210                 215                 220                 


Met Lys Met Pro Thr Met Val Pro Leu Ser Leu Leu Ser Val Pro Gln 
225                 230                 235                 240 


Leu Ser Gly Ala Gly Gly Gly Gly Gly Glu Ala Gly Ala Gly Gly Gly 
                245                 250                 255     


Ala Ala Ala Val Ala Ala Gly Gly Val Val Thr Thr Thr Ala Ser Gly 
            260                 265                 270         


Lys Arg Ile Arg Lys Asn His Ala Cys Glu Met Cys Gly Lys Ala Phe 
        275                 280                 285             


Arg Asp Val Tyr His Leu Asn Arg His Lys Leu Ser His Ser Asp Glu 
    290                 295                 300                 


Lys Pro Tyr Gln Cys Pro Val Cys Gln Gln Arg Phe Lys Arg Lys Asp 
305                 310                 315                 320 


Arg Met Ser Tyr His Val Arg Ser His Asp Gly Ala Val His Lys Pro 
                325                 330                 335     


Tyr Asn Cys Ser His Cys Gly Lys Ser Phe Ser Arg Pro Asp His Leu 
            340                 345                 350         


Asn Ser His Val Arg Gln Val His Ser Thr Glu Arg Pro Phe Lys Cys 
        355                 360                 365             


Glu Lys Cys Glu Ala Ala Phe Ala Thr Lys Asp Arg Leu Arg Ala His 
    370                 375                 380                 


Thr Val Arg His Glu Glu Lys Val Pro Cys His Val Cys Gly Lys Met 
385                 390                 395                 400 


Leu Ser Ser Ala Tyr Ile Ser Asp His Met Lys Val His Ser Gln Gly 
                405                 410                 415     


Pro His His Val Cys Glu Leu Cys Asn Lys Gly Thr Gly Glu Val Cys 
            420                 425                 430         


Pro Met Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        435                 440                 445             


Val Ala Ala Pro Pro Thr Ala Val Gly Ser Leu Ser Gly Ala Glu Gly 
    450                 455                 460                 


Val Pro Val Ser Ser Gln Pro Leu Pro Ser Gln Pro Trp 
465                 470                 475         


<210>  8385
<211>  84
<212>  PRT
<213>  Homo Sapiens

<400>  8385

Met Phe Pro Val Phe Pro Cys Thr Leu Leu Ala Pro Pro Phe Pro Val 
1               5                   10                  15      


Leu Gly Leu Asp Ser Arg Gly Val Gly Gly Leu Met Asn Ser Phe Pro 
            20                  25                  30          


Pro Pro Gln Gly His Ala Gln Asn Pro Leu Gln Val Gly Ala Glu Leu 
        35                  40                  45              


Gln Ser Arg Phe Phe Ala Ser Gln Gly Cys Ala Gln Ser Pro Phe Gln 
    50                  55                  60                  


Ala Gly Ser Pro Gln Gln Ser Arg Gln Thr Ser Ala Leu Asn Arg Thr 
65                  70                  75                  80  


Ala Leu Gln Met 
                


<210>  8386
<211>  172
<212>  PRT
<213>  Homo Sapiens

<400>  8386

Met Phe Pro Val Phe Pro Cys Thr Leu Leu Ala Pro Pro Phe Pro Val 
1               5                   10                  15      


Leu Gly Leu Asp Ser Arg Gly Val Gly Gly Leu Met Asn Ser Phe Pro 
            20                  25                  30          


Pro Pro Gln Gly His Ala Gln Asn Pro Leu Gln Val Gly Ala Glu Leu 
        35                  40                  45              


Gln Ser Arg Phe Phe Ala Ser Gln Gly Cys Ala Gln Ser Pro Phe Gln 
    50                  55                  60                  


Lys Cys Glu Ala Ala Phe Ala Thr Lys Asp Arg Leu Arg Ala His Thr 
65                  70                  75                  80  


Val Arg His Glu Glu Lys Val Pro Cys His Val Cys Gly Lys Met Leu 
                85                  90                  95      


Ser Ser Ala Tyr Ile Ser Asp His Met Lys Val His Ser Gln Gly Pro 
            100                 105                 110         


His His Val Cys Glu Leu Cys Asn Lys Gly Thr Gly Glu Val Cys Pro 
        115                 120                 125             


Met Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Val 
    130                 135                 140                 


Ala Ala Pro Pro Thr Ala Val Gly Ser Leu Ser Gly Ala Glu Gly Val 
145                 150                 155                 160 


Pro Val Ser Ser Gln Pro Leu Pro Ser Gln Pro Trp 
                165                 170         


<210>  8387
<211>  252
<212>  PRT
<213>  Homo Sapiens

<400>  8387

Met Lys Met Pro Thr Met Val Pro Leu Ser Leu Leu Ser Val Pro Gln 
1               5                   10                  15      


Leu Ser Gly Ala Gly Gly Gly Gly Gly Glu Ala Gly Ala Gly Gly Gly 
            20                  25                  30          


Ala Ala Ala Val Ala Ala Gly Gly Val Val Thr Thr Thr Ala Ser Gly 
        35                  40                  45              


Lys Arg Ile Arg Lys Asn His Ala Cys Glu Met Cys Gly Lys Ala Phe 
    50                  55                  60                  


Arg Asp Val Tyr His Leu Asn Arg His Lys Leu Ser His Ser Asp Glu 
65                  70                  75                  80  


Lys Pro Tyr Gln Cys Pro Val Cys Gln Gln Arg Phe Lys Arg Lys Asp 
                85                  90                  95      


Arg Met Ser Tyr His Val Arg Ser His Arg Arg Cys Ala Lys Pro Tyr 
            100                 105                 110         


Asn Cys Ser His Cys Gly Lys Ser Phe Ser Arg Pro Asp His Leu Asn 
        115                 120                 125             


Ser His Val Arg Gln Val His Ser Thr Glu Arg Pro Phe Lys Cys Glu 
    130                 135                 140                 


Lys Cys Glu Ala Ala Phe Ala Thr Lys Asp Arg Leu Arg Ala His Thr 
145                 150                 155                 160 


Val Arg His Glu Glu Lys Val Pro Cys His Val Cys Gly Lys Met Leu 
                165                 170                 175     


Ser Ser Ala Tyr Ile Ser Asp His Met Lys Val His Ser Gln Gly Pro 
            180                 185                 190         


His His Val Cys Glu Leu Cys Asn Lys Gly Thr Gly Glu Val Cys Pro 
        195                 200                 205             


Met Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Val 
    210                 215                 220                 


Ala Ala Pro Pro Thr Ala Val Gly Ser Leu Ser Gly Ala Glu Gly Val 
225                 230                 235                 240 


Pro Val Ser Ser Gln Pro Leu Pro Ser Gln Pro Trp 
                245                 250         


<210>  8388
<211>  79
<212>  PRT
<213>  Homo Sapiens

<400>  8388

Met Leu Ser Ser Ala Tyr Ile Ser Asp His Met Lys Val His Ser Gln 
1               5                   10                  15      


Gly Pro His His Val Cys Glu Leu Cys Asn Lys Gly Phe Thr Thr Ala 
            20                  25                  30          


Ala Tyr Leu Arg Ile His Ala Val Lys Asp His Gly Leu Gln Ala Pro 
        35                  40                  45              


Arg Ala Asp Arg Ile Leu Cys Lys Leu Cys Ser Val His Cys Lys Thr 
    50                  55                  60                  


Pro Ala Gln Leu Ala Gly His Met Gln Thr His Leu Gly Gly Ala 
65                  70                  75                  


<210>  8389
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  8389

Met Leu Ser Ser Ala Tyr Ile Ser Asp His Met Lys Val His Ser Gln 
1               5                   10                  15      


Gly Pro His His Val Cys Glu Leu Cys Asn Lys Gly Phe Thr Thr Ala 
            20                  25                  30          


Ala Tyr Leu Arg Ile His Ala Val Lys Asp His Gly Leu Gln Ala Pro 
        35                  40                  45              


Arg Ala Asp Arg Ile Leu Cys Lys Leu Cys Ser Val His Cys Lys Thr 
    50                  55                  60                  


Pro Ala Gln Leu Ala Gly His Met Gln Thr His Leu Gly Gly Ala Ala 
65                  70                  75                  80  


Pro Pro Val Pro Gly Asp Ala Pro Gln Pro Gln Pro Thr Cys 
                85                  90                  


<210>  8390
<211>  53
<212>  PRT
<213>  Homo Sapiens

<400>  8390

Met Leu Ser Ser Ala Tyr Ile Ser Asp His Met Lys Val His Ser Gln 
1               5                   10                  15      


Gly Pro His His Val Cys Glu Leu Cys Asn Lys Gly Thr Cys Arg Gly 
            20                  25                  30          


Leu Pro Gly Gly Pro Gly Ala Glu Gly Gly Arg Leu Ala Arg Arg Leu 
        35                  40                  45              


Ala Thr Asp Thr Gly 
    50              


<210>  8391
<211>  78
<212>  PRT
<213>  Homo Sapiens

<400>  8391

Met Leu Ser Ser Ala Tyr Ile Ser Asp His Met Lys Val His Ser Gln 
1               5                   10                  15      


Gly Pro His His Val Cys Glu Leu Cys Asn Lys Gly Thr Gly Glu Val 
            20                  25                  30          


Cys Pro Met Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        35                  40                  45              


Ala Val Ala Ala Pro Pro Thr Ala Val Gly Ser Leu Ser Gly Ala Glu 
    50                  55                  60                  


Gly Val Pro Val Ser Ser Gln Pro Leu Pro Ser Gln Pro Trp 
65                  70                  75              


<210>  8392
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  8392

Ser Phe Ser Arg Cys Ala Arg Gly Leu Gly Arg Pro Leu Gly Arg Gly 
1               5                   10                  15      


Glu Gly Gly Thr Arg Arg Arg Pro Asp His Leu Asn Ser His Val Arg 
            20                  25                  30          


Gln Val His Ser Thr Glu Arg Pro Phe Lys Cys Glu Lys Cys Glu Ala 
        35                  40                  45              


Ala Phe Ala Thr Lys Asp Arg Leu Arg Ala His Thr Val Arg His Glu 
    50                  55                  60                  


Glu Lys Val Pro Cys His Val Cys Gly Lys Met Leu Ser Ser Ala Tyr 
65                  70                  75                  80  


Ile Ser Asp His Met Lys Val His Ser Gln Gly Pro His His Val Cys 
                85                  90                  95      


Glu Leu Cys Asn Lys Gly Thr Gly Glu Val Cys Pro Met Ala Ala Ala 
            100                 105                 110         


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Ala Ala Pro Pro 
        115                 120                 125             


Thr Ala Val Gly Ser Leu Ser Gly Ala Glu Gly Val Pro Val Ser Ser 
    130                 135                 140                 


Gln Pro Leu Pro Ser Gln Pro Trp 
145                 150         


<210>  8393
<211>  196
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8393

Xaa Gly Ala Val His Lys Pro Tyr Asn Cys Ser His Cys Gly Lys Ser 
1               5                   10                  15      


Phe Ser Arg Pro Asp His Leu Asn Ser His Val Arg Gln Val His Ser 
            20                  25                  30          


Thr Glu Arg Pro Phe Lys Cys Glu Lys Cys Glu Ala Ala Phe Ala Thr 
        35                  40                  45              


Lys Asp Arg Leu Arg Ala His Thr Val Arg His Glu Glu Lys Val Pro 
    50                  55                  60                  


Cys His Val Cys Gly Lys Met Leu Ser Ser Ala Tyr Ile Ser Asp His 
65                  70                  75                  80  


Met Lys Val His Ser Gln Gly Pro His His Val Cys Glu Leu Cys Asn 
                85                  90                  95      


Lys Gly Thr Gly Glu Val Cys Pro Met Ala Ala Ala Ala Ala Ala Ala 
            100                 105                 110         


Ala Ala Ala Ala Ala Ala Ala Val Ala Ala Pro Pro Thr Ala Val Gly 
        115                 120                 125             


Ser Leu Ser Gly Ala Glu Gly Val Pro Val Ser Ser Gln Pro Leu Pro 
    130                 135                 140                 


Ser Gln Pro Cys Ser Ser Pro Gly Leu Val Phe Ser Ser Leu Phe Pro 
145                 150                 155                 160 


Thr Thr Glu Glu Val Val Ala Leu Ala Met Ser Ser Cys Ser Cys Val 
                165                 170                 175     


Pro Cys Met Tyr Pro Thr Leu His Pro Phe Leu Leu Arg Gly Pro His 
            180                 185                 190         


Tyr Asn Lys Phe 
        195     


<210>  8394
<211>  177
<212>  PRT
<213>  Homo Sapiens

<400>  8394

Glu Ser Ser Gly Ala Asp Arg Ala Gly Gly Pro Val Ala Thr Ser Val 
1               5                   10                  15      


Pro Ile Gly Trp Gln Arg Cys Val Arg Glu Gly Ala Val Leu Tyr Ile 
            20                  25                  30          


Ser Pro Ser Gly Thr Glu Leu Ser Ser Leu Glu Gln Thr Arg Ser Tyr 
        35                  40                  45              


Leu Leu Ser Asp Gly Thr Cys Lys Cys Gly Leu Glu Cys Pro Leu Asn 
    50                  55                  60                  


Val Pro Lys Val Phe Asn Phe Asp Pro Leu Ala Pro Val Thr Pro Gly 
65                  70                  75                  80  


Gly Ala Gly Val Gly Pro Ala Ser Glu Glu Asp Met Thr Lys Leu Cys 
                85                  90                  95      


Asn His Arg Arg Lys Ala Val Ala Met Ala Thr Leu Tyr Arg Ser Met 
            100                 105                 110         


Glu Thr Thr Cys Ser His Ser Ser Pro Gly Ser Pro Pro Gln Pro Arg 
        115                 120                 125             


His Pro Ile Gln Pro Ser Leu Pro Gly Thr Thr Ser Gly Ser Leu Ser 
    130                 135                 140                 


Ser Val Pro Gly Ala Pro Ala Pro Pro Ala Ala Ser Lys Ala Pro Val 
145                 150                 155                 160 


Val Pro Ser Pro Val Leu Gln Ser Pro Ser Glu Gly Leu Gly Met Gly 
                165                 170                 175     


Ala 
    


<210>  8395
<211>  504
<212>  PRT
<213>  Homo Sapiens

<400>  8395

Gly Met Gly Ala Gly Pro Ala Cys Pro Leu Pro Pro Leu Ala Gly Gly 
1               5                   10                  15      


Glu Ala Phe Pro Phe Pro Ser Pro Glu Gln Gly Leu Ala Leu Ser Gly 
            20                  25                  30          


Ala Gly Phe Pro Gly Met Leu Gly Ala Leu Pro Leu Pro Leu Ser Leu 
        35                  40                  45              


Gly Gln Pro Pro Pro Ser Pro Leu Leu Asn His Ser Leu Phe Gly Val 
    50                  55                  60                  


Leu Thr Gly Gly Gly Gly Gln Pro Pro Pro Glu Pro Leu Leu Pro Pro 
65                  70                  75                  80  


Pro Gly Gly Pro Gly Pro Pro Leu Ala Pro Gly Glu Pro Glu Gly Pro 
                85                  90                  95      


Ser Leu Leu Val Ala Ser Leu Leu Pro Pro Pro Pro Ser Asp Leu Leu 
            100                 105                 110         


Pro Pro Pro Ser Ala Pro Pro Ser Asn Leu Leu Ala Ser Phe Leu Pro 
        115                 120                 125             


Leu Leu Ala Leu Gly Pro Thr Ala Gly Asp Gly Glu Gly Ser Ala Glu 
    130                 135                 140                 


Gly Ala Gly Gly Pro Ser Gly Glu Pro Phe Ser Gly Leu Gly Asp Leu 
145                 150                 155                 160 


Ser Pro Leu Leu Phe Pro Pro Leu Ser Ala Pro Pro Thr Leu Ile Ala 
                165                 170                 175     


Leu Asn Ser Ala Leu Leu Ala Ala Thr Leu Asp Pro Pro Ser Gly Thr 
            180                 185                 190         


Pro Pro Gln Pro Cys Val Leu Ser Ala Pro Gln Pro Gly Pro Pro Thr 
        195                 200                 205             


Ser Ser Val Thr Thr Ala Thr Thr Asp Pro Gly Ala Ser Ser Leu Gly 
    210                 215                 220                 


Lys Ala Pro Ser Asn Ser Gly Arg Pro Pro Gln Leu Leu Ser Pro Leu 
225                 230                 235                 240 


Leu Gly Ala Ser Leu Leu Gly Asp Leu Ser Ser Leu Thr Ser Ser Pro 
                245                 250                 255     


Gly Ala Leu Pro Ser Leu Leu Gln Pro Pro Gly Pro Leu Leu Ser Gly 
            260                 265                 270         


Gln Leu Gly Leu Gln Leu Leu Pro Gly Gly Gly Ala Pro Pro Pro Leu 
        275                 280                 285             


Ser Glu Ala Ser Ser Pro Leu Ala Cys Leu Leu Gln Ser Leu Gln Ile 
    290                 295                 300                 


Pro Pro Glu Gln Pro Glu Ala Pro Cys Leu Pro Pro Glu Ser Pro Ala 
305                 310                 315                 320 


Ser Ala Leu Glu Pro Glu Pro Ala Arg Pro Pro Leu Ser Ala Leu Ala 
                325                 330                 335     


Pro Pro His Gly Ser Pro Asp Pro Pro Val Pro Glu Leu Leu Thr Gly 
            340                 345                 350         


Arg Gly Ser Gly Lys Arg Gly Arg Arg Gly Gly Gly Gly Leu Arg Gly 
        355                 360                 365             


Ile Asn Gly Glu Ala Arg Pro Ala Arg Gly Arg Lys Pro Gly Ser Arg 
    370                 375                 380                 


Arg Glu Pro Gly Arg Leu Ala Leu Lys Trp Gly Thr Arg Gly Gly Phe 
385                 390                 395                 400 


Asn Gly Gln Met Glu Arg Ser Pro Arg Arg Thr His His Trp Gln His 
                405                 410                 415     


Asn Gly Glu Leu Ala Glu Gly Gly Ala Glu Pro Lys Asp Pro Pro Pro 
            420                 425                 430         


Pro Gly Pro His Ser Glu Asp Leu Lys Val Pro Pro Gly Val Val Arg 
        435                 440                 445             


Lys Ser Arg Arg Gly Arg Arg Arg Lys Tyr Asn Pro Thr Arg Asn Ser 
    450                 455                 460                 


Asn Ser Ser Arg Gln Asp Ile Thr Leu Glu Pro Ser Pro Thr Ala Arg 
465                 470                 475                 480 


Ala Ala Val Pro Leu Pro Pro Arg Ala Arg Pro Gly Arg Pro Ala Lys 
                485                 490                 495     


Asn Lys Arg Arg Lys Leu Ala Pro 
            500                 


<210>  8396
<211>  47
<212>  PRT
<213>  Homo Sapiens

<400>  8396

Met Asn Gly Gly Asn Glu Ser Ser Gly Ala Asp Arg Ala Gly Gly Pro 
1               5                   10                  15      


Val Ala Thr Ser Val Pro Ile Gly Trp Gln Arg Cys Val Arg Glu Gly 
            20                  25                  30          


Ala Val Leu Tyr Ile Arg Arg Ile Cys Asn Leu Ser Thr Val Leu 
        35                  40                  45          


<210>  8397
<211>  45
<212>  PRT
<213>  Homo Sapiens

<400>  8397

Met Asn Gly Gly Asn Glu Ser Ser Gly Ala Asp Arg Ala Gly Gly Pro 
1               5                   10                  15      


Val Ala Thr Ser Val Pro Ile Gly Trp Gln Arg Cys Val Arg Glu Gly 
            20                  25                  30          


Ala Val Leu Tyr Ile Ser Pro Ser Gly Thr Glu Leu Ser 
        35                  40                  45  


<210>  8398
<211>  53
<212>  PRT
<213>  Homo Sapiens

<400>  8398

Met Asn Gly Gly Asn Glu Ser Ser Gly Ala Asp Arg Ala Gly Gly Pro 
1               5                   10                  15      


Val Ala Thr Ser Val Pro Ile Gly Trp Gln Arg Cys Val Arg Glu Gly 
            20                  25                  30          


Ala Val Leu Tyr Ile Ser Pro Ser Gly Thr Glu Leu Ser Ser Leu Glu 
        35                  40                  45              


Gln Thr Arg Ser Tyr 
    50              


<210>  8399
<211>  53
<212>  PRT
<213>  Homo Sapiens

<400>  8399

Met Asn Gly Gly Asn Glu Ser Ser Gly Ala Asp Arg Ala Gly Gly Pro 
1               5                   10                  15      


Val Ala Thr Ser Val Pro Ile Gly Trp Gln Arg Cys Val Arg Glu Gly 
            20                  25                  30          


Ala Val Leu Tyr Ile Ser Pro Ser Gly Thr Glu Leu Ser Ser Leu Glu 
        35                  40                  45              


Gln Thr Arg Ser Tyr 
    50              


<210>  8400
<211>  73
<212>  PRT
<213>  Homo Sapiens

<400>  8400

Met Asn Gly Gly Asn Glu Ser Ser Gly Ala Asp Arg Ala Gly Gly Pro 
1               5                   10                  15      


Val Ala Thr Ser Val Pro Ile Gly Trp Gln Arg Cys Val Arg Glu Gly 
            20                  25                  30          


Ala Val Leu Tyr Ile Ser Pro Ser Gly Thr Glu Leu Ser Ser Leu Glu 
        35                  40                  45              


Gln Thr Arg Ser Tyr Leu Leu Ser Asp Gly Thr Cys Lys Cys Gly Leu 
    50                  55                  60                  


Glu Cys Pro Leu Asn Val Pro Lys Val 
65                  70              


<210>  8401
<211>  148
<212>  PRT
<213>  Homo Sapiens

<400>  8401

Met Asn Gly Gly Asn Glu Ser Ser Gly Ala Asp Arg Ala Gly Gly Pro 
1               5                   10                  15      


Val Ala Thr Ser Val Pro Ile Gly Trp Gln Arg Cys Val Arg Glu Gly 
            20                  25                  30          


Ala Val Leu Tyr Ile Ser Pro Ser Gly Thr Glu Leu Ser Ser Leu Glu 
        35                  40                  45              


Gln Thr Arg Ser Tyr Leu Leu Ser Asp Gly Thr Cys Lys Cys Gly Leu 
    50                  55                  60                  


Glu Cys Pro Leu Asn Val Pro Lys Val Phe Asn Phe Asp Pro Leu Ala 
65                  70                  75                  80  


Pro Val Thr Pro Gly Gly Ala Gly Val Gly Pro Ala Ser Glu Glu Asp 
                85                  90                  95      


Met Thr Lys Leu Cys Asn His Arg Arg Lys Ala Val Ala Met Ala Thr 
            100                 105                 110         


Leu Tyr Arg Ser Met Glu Thr Thr Cys Ser His Ser Ser Pro Gly Glu 
        115                 120                 125             


Gly Ala Ser Pro Gln Met Phe His Thr Val Ser Pro Gly Pro Pro Ser 
    130                 135                 140                 


Ala Arg Pro Pro 
145             


<210>  8402
<211>  1003
<212>  PRT
<213>  Homo Sapiens

<400>  8402

Met Asn Gly Gly Asn Glu Ser Ser Gly Ala Asp Arg Ala Gly Gly Pro 
1               5                   10                  15      


Val Ala Thr Ser Val Pro Ile Gly Trp Gln Arg Cys Val Arg Glu Gly 
            20                  25                  30          


Ala Val Leu Tyr Ile Ser Pro Ser Gly Thr Glu Leu Ser Ser Leu Glu 
        35                  40                  45              


Gln Thr Arg Ser Tyr Leu Leu Ser Asp Gly Thr Cys Lys Cys Gly Leu 
    50                  55                  60                  


Glu Cys Pro Leu Asn Val Pro Lys Val Phe Asn Phe Asp Pro Leu Ala 
65                  70                  75                  80  


Pro Val Thr Pro Gly Gly Ala Gly Val Gly Pro Ala Ser Glu Glu Asp 
                85                  90                  95      


Met Thr Lys Leu Cys Asn His Arg Arg Lys Ala Val Ala Met Ala Thr 
            100                 105                 110         


Leu Tyr Arg Ser Met Glu Thr Thr Cys Ser His Ser Ser Pro Gly Glu 
        115                 120                 125             


Gly Ala Ser Pro Gln Met Phe His Thr Val Ser Pro Gly Pro Pro Ser 
    130                 135                 140                 


Ala Arg Pro Pro Cys Arg Val Pro Pro Thr Thr Pro Leu Asn Gly Gly 
145                 150                 155                 160 


Pro Gly Ser Leu Pro Pro Glu Pro Pro Ser Val Ser Gln Ala Phe Pro 
                165                 170                 175     


Thr Leu Ala Gly Pro Gly Gly Leu Phe Pro Pro Arg Leu Ala Asp Pro 
            180                 185                 190         


Val Pro Ser Gly Gly Ser Ser Ser Pro Arg Phe Leu Pro Arg Gly Asn 
        195                 200                 205             


Ala Pro Ser Pro Ala Pro Pro Pro Pro Pro Ala Ile Ser Leu Asn Ala 
    210                 215                 220                 


Pro Ser Tyr Asn Trp Gly Ala Ala Leu Arg Ser Ser Leu Val Pro Ser 
225                 230                 235                 240 


Asp Leu Gly Ser Pro Pro Ala Pro His Ala Ser Ser Ser Pro Pro Ser 
                245                 250                 255     


Asp Pro Pro Leu Phe His Cys Ser Asp Ala Leu Thr Pro Pro Pro Leu 
            260                 265                 270         


Pro Pro Ser Asn Asn Leu Pro Ala His Pro Gly Pro Ala Ser Gln Pro 
        275                 280                 285             


Pro Val Ser Ser Ala Thr Met His Leu Pro Leu Val Leu Gly Pro Leu 
    290                 295                 300                 


Gly Gly Ala Pro Thr Val Glu Gly Pro Gly Ala Pro Pro Phe Leu Ala 
305                 310                 315                 320 


Ser Ser Leu Leu Ser Ala Ala Ala Lys Ala Gln His Pro Pro Leu Pro 
                325                 330                 335     


Pro Pro Ser Thr Leu Gln Gly Arg Arg Pro Arg Ala Gln Ala Pro Ser 
            340                 345                 350         


Ala Ser His Ser Ser Ser Leu Arg Pro Ser Gln Arg Arg Pro Arg Arg 
        355                 360                 365             


Pro Pro Thr Val Phe Arg Leu Leu Glu Gly Arg Gly Pro Gln Thr Pro 
    370                 375                 380                 


Arg Arg Ser Arg Pro Arg Ala Pro Ala Pro Val Pro Gln Pro Phe Ser 
385                 390                 395                 400 


Leu Pro Glu Pro Ser Gln Pro Ile Leu Pro Ser Val Leu Ser Leu Leu 
                405                 410                 415     


Gly Leu Pro Thr Pro Gly Pro Ser His Ser Asp Gly Ser Phe Asn Leu 
            420                 425                 430         


Leu Gly Ser Asp Ala His Leu Pro Pro Pro Pro Thr Leu Ser Ser Gly 
        435                 440                 445             


Ser Pro Pro Gln Pro Arg His Pro Ile Gln Pro Ser Leu Pro Gly Thr 
    450                 455                 460                 


Thr Ser Gly Ser Leu Ser Ser Val Pro Gly Ala Pro Ala Pro Pro Ala 
465                 470                 475                 480 


Ala Ser Lys Ala Pro Val Val Pro Ser Pro Val Leu Gln Ser Pro Ser 
                485                 490                 495     


Glu Gly Leu Gly Met Gly Ala Gly Pro Ala Cys Pro Leu Pro Pro Leu 
            500                 505                 510         


Ala Gly Gly Glu Ala Phe Pro Phe Pro Ser Pro Glu Gln Gly Leu Ala 
        515                 520                 525             


Leu Ser Gly Ala Gly Phe Pro Gly Met Leu Gly Ala Leu Pro Leu Pro 
    530                 535                 540                 


Leu Ser Leu Gly Gln Pro Pro Pro Ser Pro Leu Leu Asn His Ser Leu 
545                 550                 555                 560 


Phe Gly Val Leu Thr Gly Gly Gly Gly Gln Pro Pro Pro Glu Pro Leu 
                565                 570                 575     


Leu Pro Pro Pro Gly Gly Pro Gly Pro Pro Leu Ala Pro Gly Glu Pro 
            580                 585                 590         


Glu Gly Pro Ser Leu Leu Val Ala Ser Leu Leu Pro Pro Pro Pro Ser 
        595                 600                 605             


Asp Leu Leu Pro Pro Pro Ser Ala Pro Pro Ser Asn Leu Leu Ala Ser 
    610                 615                 620                 


Phe Leu Pro Leu Leu Ala Leu Gly Pro Thr Ala Gly Asp Gly Glu Gly 
625                 630                 635                 640 


Ser Ala Glu Gly Ala Gly Gly Pro Ser Gly Glu Pro Phe Ser Gly Leu 
                645                 650                 655     


Gly Asp Leu Ser Pro Leu Leu Phe Pro Pro Leu Ser Ala Pro Pro Thr 
            660                 665                 670         


Leu Ile Ala Leu Asn Ser Ala Leu Leu Ala Ala Thr Leu Asp Pro Pro 
        675                 680                 685             


Ser Gly Thr Pro Pro Gln Pro Cys Val Leu Ser Ala Pro Gln Pro Gly 
    690                 695                 700                 


Pro Pro Thr Ser Ser Val Thr Thr Ala Thr Thr Asp Pro Gly Ala Ser 
705                 710                 715                 720 


Ser Leu Gly Lys Ala Pro Ser Asn Ser Gly Arg Pro Pro Gln Leu Leu 
                725                 730                 735     


Ser Pro Leu Leu Gly Ala Ser Leu Leu Gly Asp Leu Ser Ser Leu Thr 
            740                 745                 750         


Ser Ser Pro Gly Ala Leu Pro Ser Leu Leu Gln Pro Pro Gly Pro Leu 
        755                 760                 765             


Leu Ser Gly Gln Leu Gly Leu Gln Leu Leu Pro Gly Gly Gly Ala Pro 
    770                 775                 780                 


Pro Pro Leu Ser Glu Ala Ser Ser Pro Leu Ala Cys Leu Leu Gln Ser 
785                 790                 795                 800 


Leu Gln Ile Pro Pro Glu Gln Pro Glu Ala Pro Cys Leu Pro Pro Glu 
                805                 810                 815     


Ser Pro Ala Ser Ala Leu Glu Pro Glu Pro Ala Arg Pro Pro Leu Ser 
            820                 825                 830         


Ala Leu Ala Pro Pro His Gly Ser Pro Asp Pro Pro Val Pro Glu Leu 
        835                 840                 845             


Leu Thr Gly Arg Gly Ser Gly Lys Arg Gly Arg Arg Gly Gly Gly Gly 
    850                 855                 860                 


Leu Arg Gly Ile Asn Gly Glu Ala Arg Pro Ala Arg Gly Arg Lys Pro 
865                 870                 875                 880 


Gly Ser Arg Arg Glu Pro Gly Arg Leu Ala Leu Lys Trp Gly Thr Arg 
                885                 890                 895     


Gly Gly Phe Asn Gly Gln Met Glu Arg Ser Pro Arg Arg Thr His His 
            900                 905                 910         


Trp Gln His Asn Gly Glu Leu Ala Glu Gly Gly Ala Glu Pro Lys Asp 
        915                 920                 925             


Pro Pro Pro Pro Gly Pro His Ser Glu Asp Leu Lys Val Pro Pro Gly 
    930                 935                 940                 


Val Val Arg Lys Ser Arg Arg Gly Arg Arg Arg Lys Tyr Asn Pro Thr 
945                 950                 955                 960 


Arg Asn Ser Asn Ser Ser Arg Gln Asp Ile Thr Leu Glu Pro Ser Pro 
                965                 970                 975     


Thr Ala Arg Ala Ala Val Pro Leu Pro Pro Arg Ala Arg Pro Gly Arg 
            980                 985                 990         


Pro Ala Lys Asn Lys Arg Arg Lys  Leu Ala Pro 
        995                 1000             


<210>  8403
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  8403

Met Thr Lys Leu Cys Asn His Arg Arg Lys Ala Val Ala Met Ala Thr 
1               5                   10                  15      


Leu Tyr Arg Ser Met Glu Thr Thr Cys Ser His Ser Ser Pro Gly Glu 
            20                  25                  30          


Gly Ala Ser Pro Gln Met Phe His Thr Val Ser Pro Gly Pro Pro Ser 
        35                  40                  45              


Ala Arg Pro Pro Cys Arg Val Pro Pro Thr Thr Pro Leu Asn Gly Gly 
    50                  55                  60                  


Pro Gly 
65      


<210>  8404
<211>  27
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8404

Xaa Ala Arg Ala Ala Val Pro Leu Pro Pro Arg Ala Arg Pro Gly Arg 
1               5                   10                  15      


Pro Ala Lys Asn Lys Arg Arg Lys Leu Ala Pro 
            20                  25          


<210>  8405
<211>  190
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8405

Xaa Leu Leu Ser Gly Gln Leu Gly Leu Gln Leu Leu Pro Gly Gly Gly 
1               5                   10                  15      


Ala Pro Pro Pro Leu Ser Glu Ala Ser Ser Pro Leu Ala Cys Leu Leu 
            20                  25                  30          


Gln Ser Leu Gln Gln Ile Pro Pro Glu Gln Pro Glu Ala Pro Cys Leu 
        35                  40                  45              


Pro Pro Glu Ser Pro Ala Ser Ala Leu Glu Pro Glu Pro Ala Arg Pro 
    50                  55                  60                  


Pro Leu Ser Ala Leu Ala Pro Pro His Gly Ser Pro Asp Pro Pro Val 
65                  70                  75                  80  


Pro Glu Leu Leu Thr Gly Arg Gly Ser Gly Lys Arg Gly Arg Arg Gly 
                85                  90                  95      


Gly Gly Gly Leu Arg Gly Ile Asn Gly Glu Ala Arg Pro Ala Arg Gly 
            100                 105                 110         


Arg Lys Pro Gly Ser Arg Arg Glu Pro Gly Arg Leu Ala Leu Lys Trp 
        115                 120                 125             


Gly Thr Arg Gly Gly Phe Asn Gly Gln Met Glu Arg Ser Pro Arg Arg 
    130                 135                 140                 


Thr His His Trp Gln His Asn Gly Glu Leu Ala Glu Gly Gly Ala Glu 
145                 150                 155                 160 


Pro Lys Asp Pro Pro Pro Pro Gly Pro His Ser Glu Asp Leu Lys Val 
                165                 170                 175     


Pro Pro Gly Val Val Arg Lys Ser Arg Arg Gly Arg Arg Arg 
            180                 185                 190 


<210>  8406
<211>  248
<212>  PRT
<213>  Homo Sapiens

<400>  8406

Met Ser Leu Phe Pro Ser Leu Pro Leu Leu Leu Leu Ser Met Val Ala 
1               5                   10                  15      


Ala Ser Tyr Ser Glu Thr Val Thr Cys Glu Asp Ala Gln Lys Thr Cys 
            20                  25                  30          


Pro Ala Val Ile Ala Cys Ser Ser Pro Gly Ile Asn Gly Phe Pro Gly 
        35                  40                  45              


Lys Asp Gly Arg Asp Gly Thr Lys Gly Glu Lys Gly Glu Pro Gly Gln 
    50                  55                  60                  


Gly Leu Arg Gly Leu Gln Gly Pro Pro Gly Lys Leu Gly Pro Pro Gly 
65                  70                  75                  80  


Asn Pro Gly Pro Ser Gly Ser Pro Gly Pro Lys Gly Gln Lys Gly Asp 
                85                  90                  95      


Pro Gly Lys Ser Pro Asp Gly Asp Ser Ser Leu Ala Ala Ser Glu Arg 
            100                 105                 110         


Lys Ala Leu Gln Thr Glu Met Ala Arg Ile Lys Lys Trp Leu Thr Phe 
        115                 120                 125             


Ser Leu Gly Lys Gln Val Gly Asn Lys Phe Phe Leu Thr Asn Gly Glu 
    130                 135                 140                 


Ile Met Thr Phe Glu Lys Val Lys Ala Leu Cys Val Lys Phe Gln Ala 
145                 150                 155                 160 


Ser Val Ala Thr Pro Arg Asn Ala Ala Glu Asn Gly Ala Ile Gln Asn 
                165                 170                 175     


Leu Ile Lys Glu Glu Ala Phe Leu Gly Ile Thr Asp Glu Lys Thr Glu 
            180                 185                 190         


Gly Gln Phe Val Asp Leu Thr Gly Asn Arg Leu Thr Tyr Thr Asn Trp 
        195                 200                 205             


Asn Glu Gly Glu Pro Asn Asn Ala Gly Ser Asp Glu Asp Cys Val Leu 
    210                 215                 220                 


Leu Leu Lys Asn Gly Gln Trp Asn Asp Val Pro Cys Ser Thr Ser His 
225                 230                 235                 240 


Leu Ala Val Cys Glu Phe Pro Ile 
                245             


<210>  8407
<211>  90
<212>  PRT
<213>  Homo Sapiens

<400>  8407

Met Ala Met Leu Ala Gln Gln Met Gln Leu Ala Asn Ala Met Met Pro 
1               5                   10                  15      


Gly Ala Pro Leu Gln Pro Val Pro Met Phe Ser Val Ala Pro Ser Leu 
            20                  25                  30          


Ala Thr Asn Ala Ser Ala Ala Ala Phe Asn Pro Tyr Leu Gly Pro Val 
        35                  40                  45              


Ser Pro Ser Leu Val Pro Ala Glu Ile Leu Pro Thr Ala Pro Met Leu 
    50                  55                  60                  


Val Thr Gly Asn Pro Gly Val Pro Val Pro Ala Ala Ala Ala Ala Ala 
65                  70                  75                  80  


Ala Gln Lys Leu Met Arg Thr Asp Arg Leu 
                85                  90  


<210>  8408
<211>  155
<212>  PRT
<213>  Homo Sapiens

<400>  8408

Met Ala Met Leu Ala Gln Gln Met Gln Leu Ala Asn Ala Met Met Pro 
1               5                   10                  15      


Gly Ala Pro Leu Gln Pro Val Pro Met Phe Ser Val Ala Pro Ser Leu 
            20                  25                  30          


Ala Thr Asn Ala Ser Ala Ala Ala Phe Asn Pro Tyr Leu Gly Pro Val 
        35                  40                  45              


Ser Pro Ser Leu Val Pro Ala Glu Ile Leu Pro Thr Ala Pro Met Leu 
    50                  55                  60                  


Val Thr Gly Asn Pro Gly Val Pro Val Pro Ala Ala Ala Ala Ala Ala 
65                  70                  75                  80  


Ala Gln Lys Leu Met Arg Thr Asp Arg Leu Glu Val Cys Arg Glu Tyr 
                85                  90                  95      


Gln Arg Gly Asn Cys Asn Arg Gly Glu Asn Asp Cys Arg Phe Ala His 
            100                 105                 110         


Pro Ala Asp Ser Thr Met Ile Asp Thr Asn Asp Asn Thr Val Thr Val 
        115                 120                 125             


Cys Met Asp Tyr Ile Lys Gly Arg Cys Ser Arg Glu Lys Cys Lys Tyr 
    130                 135                 140                 


Phe His Pro Pro Ala His Leu Gln Ala Lys Ile 
145                 150                 155 


<210>  8409
<211>  388
<212>  PRT
<213>  Homo Sapiens

<400>  8409

Met Ala Val Ser Val Thr Pro Ile Arg Asp Thr Lys Trp Leu Thr Leu 
1               5                   10                  15      


Glu Val Cys Arg Glu Phe Gln Arg Gly Thr Cys Ser Arg Pro Asp Thr 
            20                  25                  30          


Glu Cys Lys Phe Ala His Pro Ser Lys Ser Cys Gln Val Glu Asn Gly 
        35                  40                  45              


Arg Val Ile Ala Cys Phe Asp Ser Leu Lys Gly Arg Cys Ser Arg Glu 
    50                  55                  60                  


Asn Cys Lys Tyr Leu His Pro Pro Pro His Leu Lys Thr Gln Leu Glu 
65                  70                  75                  80  


Ile Asn Gly Arg Asn Asn Leu Ile Gln Gln Lys Asn Met Ala Met Leu 
                85                  90                  95      


Ala Gln Gln Met Gln Leu Ala Asn Ala Met Met Pro Gly Ala Pro Leu 
            100                 105                 110         


Gln Pro Val Pro Met Phe Ser Val Ala Pro Ser Leu Ala Thr Asn Ala 
        115                 120                 125             


Ser Ala Ala Ala Phe Asn Pro Tyr Leu Gly Pro Val Ser Pro Ser Leu 
    130                 135                 140                 


Val Pro Ala Glu Ile Leu Pro Thr Ala Pro Met Leu Val Thr Gly Asn 
145                 150                 155                 160 


Pro Gly Val Pro Val Pro Ala Ala Ala Ala Ala Ala Ala Gln Lys Leu 
                165                 170                 175     


Met Arg Thr Asp Arg Leu Glu Val Cys Arg Glu Tyr Gln Arg Gly Asn 
            180                 185                 190         


Cys Asn Arg Gly Glu Asn Asp Cys Arg Phe Ala His Pro Ala Asp Ser 
        195                 200                 205             


Thr Met Ile Asp Thr Asn Asp Asn Thr Val Thr Val Cys Met Asp Tyr 
    210                 215                 220                 


Ile Lys Gly Arg Cys Ser Arg Glu Lys Cys Lys Tyr Phe His Pro Pro 
225                 230                 235                 240 


Ala His Leu Gln Ala Lys Ile Lys Ala Ala Gln Tyr Gln Val Asn Gln 
                245                 250                 255     


Ala Ala Ala Ala Gln Ala Ala Ala Thr Ala Ala Ala Met Thr Gln Ser 
            260                 265                 270         


Ala Val Lys Ser Leu Lys Arg Pro Leu Glu Ala Thr Phe Asp Leu Gly 
        275                 280                 285             


Ile Pro Gln Ala Val Leu Pro Pro Leu Pro Lys Arg Pro Ala Leu Glu 
    290                 295                 300                 


Lys Thr Asn Gly Ala Thr Ala Val Phe Asn Thr Gly Ile Phe Gln Tyr 
305                 310                 315                 320 


Gln Gln Ala Leu Ala Asn Met Gln Leu Gln Gln His Thr Ala Phe Leu 
                325                 330                 335     


Pro Pro Val Pro Met Val His Gly Ala Thr Pro Ala Thr Val Ser Ala 
            340                 345                 350         


Ala Thr Thr Ser Ala Thr Ser Val Pro Phe Ala Ala Thr Ala Thr Ala 
        355                 360                 365             


Asn Gln Ile Pro Ile Ile Ser Ala Glu His Leu Thr Ser His Lys Tyr 
    370                 375                 380                 


Val Thr Gln Met 
385             


<210>  8410
<211>  400
<212>  PRT
<213>  Homo Sapiens

<400>  8410

Met Ala Val Ser Val Thr Pro Ile Arg Asp Thr Lys Trp Leu Thr Leu 
1               5                   10                  15      


Glu Val Cys Arg Glu Phe Gln Arg Gly Thr Cys Ser Arg Pro Asp Thr 
            20                  25                  30          


Glu Cys Lys Phe Ala His Pro Ser Lys Ser Cys Gln Val Glu Asn Gly 
        35                  40                  45              


Arg Val Ile Ala Cys Phe Asp Ser Leu Lys Gly Arg Cys Ser Arg Glu 
    50                  55                  60                  


Asn Cys Lys Tyr Leu His Pro Pro Pro His Leu Lys Thr Gln Leu Glu 
65                  70                  75                  80  


Ile Asn Gly Arg Asn Asn Leu Ile Gln Gln Lys Asn Met Ala Met Leu 
                85                  90                  95      


Ala Gln Gln Met Gln Leu Ala Asn Ala Met Met Pro Gly Ala Pro Leu 
            100                 105                 110         


Gln Pro Val Pro Met Phe Ser Val Ala Pro Ser Leu Ala Thr Asn Ala 
        115                 120                 125             


Ser Ala Ala Ala Phe Asn Pro Tyr Leu Gly Pro Val Ser Pro Ser Leu 
    130                 135                 140                 


Val Pro Ala Glu Ile Leu Pro Thr Ala Pro Met Leu Val Thr Gly Asn 
145                 150                 155                 160 


Pro Gly Val Pro Val Pro Ala Ala Ala Ala Ala Ala Ala Gln Lys Leu 
                165                 170                 175     


Met Arg Thr Asp Arg Leu Glu Val Cys Arg Glu Tyr Gln Arg Gly Asn 
            180                 185                 190         


Cys Asn Arg Gly Glu Asn Asp Cys Arg Phe Ala His Pro Ala Asp Ser 
        195                 200                 205             


Thr Met Ile Asp Thr Asn Asp Asn Thr Val Thr Val Cys Met Asp Tyr 
    210                 215                 220                 


Ile Lys Gly Arg Cys Ser Arg Glu Lys Cys Lys Tyr Phe His Pro Pro 
225                 230                 235                 240 


Ala His Leu Gln Ala Lys Ile Lys Ala Ala Gln Tyr Gln Val Asn Gln 
                245                 250                 255     


Ala Ala Ala Ala Gln Ala Ala Ala Thr Ala Ala Ala Met Thr Gln Ser 
            260                 265                 270         


Ala Val Lys Ser Leu Lys Arg Pro Leu Glu Ala Thr Phe Asp Leu Gly 
        275                 280                 285             


Ile Pro Gln Ala Val Leu Pro Pro Leu Pro Lys Arg Pro Ala Leu Glu 
    290                 295                 300                 


Lys Thr Asn Gly Ala Thr Ala Val Phe Asn Thr Gly Ile Phe Gln Tyr 
305                 310                 315                 320 


Gln Gln Ala Leu Ala Asn Met Gln Leu Gln Gln His Thr Ala Phe Leu 
                325                 330                 335     


Pro Pro Gly Ser Ile Leu Cys Met Thr Pro Ala Thr Ser Val Val Pro 
            340                 345                 350         


Met Val His Gly Ala Thr Pro Ala Thr Val Ser Ala Ala Thr Thr Ser 
        355                 360                 365             


Ala Thr Ser Val Pro Phe Ala Ala Thr Ala Thr Ala Asn Gln Ile Pro 
    370                 375                 380                 


Ile Ile Ser Ala Glu His Leu Thr Ser His Lys Tyr Val Thr Gln Met 
385                 390                 395                 400 


<210>  8411
<211>  370
<212>  PRT
<213>  Homo Sapiens

<400>  8411

Met Ala Val Ser Val Thr Pro Ile Arg Asp Thr Lys Trp Leu Thr Leu 
1               5                   10                  15      


Glu Val Cys Arg Glu Phe Gln Arg Gly Thr Cys Ser Arg Pro Asp Thr 
            20                  25                  30          


Glu Cys Lys Phe Ala His Pro Ser Lys Ser Cys Gln Val Glu Asn Gly 
        35                  40                  45              


Arg Val Ile Ala Cys Phe Asp Ser Leu Lys Gly Arg Cys Ser Arg Glu 
    50                  55                  60                  


Asn Cys Lys Tyr Leu His Pro Pro Pro His Leu Lys Thr Gln Leu Glu 
65                  70                  75                  80  


Ile Asn Gly Arg Asn Asn Leu Ile Gln Gln Lys Asn Met Ala Met Leu 
                85                  90                  95      


Ala Gln Gln Met Gln Leu Ala Asn Ala Met Met Pro Gly Ala Pro Leu 
            100                 105                 110         


Gln Pro Val Pro Met Phe Ser Val Ala Pro Ser Leu Ala Thr Asn Ala 
        115                 120                 125             


Ser Ala Ala Ala Phe Asn Pro Tyr Leu Gly Pro Val Ser Pro Ser Leu 
    130                 135                 140                 


Val Pro Ala Glu Ile Leu Pro Thr Ala Pro Met Leu Val Thr Gly Asn 
145                 150                 155                 160 


Pro Gly Val Pro Val Pro Ala Ala Ala Ala Ala Ala Ala Gln Lys Leu 
                165                 170                 175     


Met Arg Thr Asp Arg Leu Glu Val Cys Arg Glu Tyr Gln Arg Gly Asn 
            180                 185                 190         


Cys Asn Arg Gly Glu Asn Asp Cys Arg Phe Ala His Pro Ala Asp Ser 
        195                 200                 205             


Thr Met Ile Asp Thr Asn Asp Asn Thr Val Thr Val Cys Met Asp Tyr 
    210                 215                 220                 


Ile Lys Gly Arg Cys Ser Arg Glu Lys Cys Lys Tyr Phe His Pro Pro 
225                 230                 235                 240 


Ala His Leu Gln Ala Lys Ile Lys Ala Ala Gln Tyr Gln Val Asn Gln 
                245                 250                 255     


Ala Ala Ala Ala Gln Ala Ala Ala Thr Ala Ala Ala Met Gly Ile Pro 
            260                 265                 270         


Gln Ala Val Leu Pro Pro Leu Pro Lys Arg Pro Ala Leu Glu Lys Thr 
        275                 280                 285             


Asn Gly Ala Thr Ala Val Phe Asn Thr Gly Ile Phe Gln Tyr Gln Gln 
    290                 295                 300                 


Ala Leu Ala Asn Met Gln Leu Gln Gln His Thr Ala Phe Leu Pro Pro 
305                 310                 315                 320 


Val Pro Met Val His Gly Ala Thr Pro Ala Thr Val Ser Ala Ala Thr 
                325                 330                 335     


Thr Ser Ala Thr Ser Val Pro Phe Ala Ala Thr Ala Thr Ala Asn Gln 
            340                 345                 350         


Ile Pro Ile Ile Ser Ala Glu His Leu Thr Ser His Lys Tyr Val Thr 
        355                 360                 365             


Gln Met 
    370 


<210>  8412
<211>  382
<212>  PRT
<213>  Homo Sapiens

<400>  8412

Met Ala Val Ser Val Thr Pro Ile Arg Asp Thr Lys Trp Leu Thr Leu 
1               5                   10                  15      


Glu Val Cys Arg Glu Phe Gln Arg Gly Thr Cys Ser Arg Pro Asp Thr 
            20                  25                  30          


Glu Cys Lys Phe Ala His Pro Ser Lys Ser Cys Gln Val Glu Asn Gly 
        35                  40                  45              


Arg Val Ile Ala Cys Phe Asp Ser Leu Lys Gly Arg Cys Ser Arg Glu 
    50                  55                  60                  


Asn Cys Lys Tyr Leu His Pro Pro Pro His Leu Lys Thr Gln Leu Glu 
65                  70                  75                  80  


Ile Asn Gly Arg Asn Asn Leu Ile Gln Gln Lys Asn Met Ala Met Leu 
                85                  90                  95      


Ala Gln Gln Met Gln Leu Ala Asn Ala Met Met Pro Gly Ala Pro Leu 
            100                 105                 110         


Gln Pro Val Pro Met Phe Ser Val Ala Pro Ser Leu Ala Thr Asn Ala 
        115                 120                 125             


Ser Ala Ala Ala Phe Asn Pro Tyr Leu Gly Pro Val Ser Pro Ser Leu 
    130                 135                 140                 


Val Pro Ala Glu Ile Leu Pro Thr Ala Pro Met Leu Val Thr Gly Asn 
145                 150                 155                 160 


Pro Gly Val Pro Val Pro Ala Ala Ala Ala Ala Ala Ala Gln Lys Leu 
                165                 170                 175     


Met Arg Thr Asp Arg Leu Glu Val Cys Arg Glu Tyr Gln Arg Gly Asn 
            180                 185                 190         


Cys Asn Arg Gly Glu Asn Asp Cys Arg Phe Ala His Pro Ala Asp Ser 
        195                 200                 205             


Thr Met Ile Asp Thr Asn Asp Asn Thr Val Thr Val Cys Met Asp Tyr 
    210                 215                 220                 


Ile Lys Gly Arg Cys Ser Arg Glu Lys Cys Lys Tyr Phe His Pro Pro 
225                 230                 235                 240 


Ala His Leu Gln Ala Lys Ile Lys Ala Ala Gln Tyr Gln Val Asn Gln 
                245                 250                 255     


Ala Ala Ala Ala Gln Ala Ala Ala Thr Ala Ala Ala Met Gly Ile Pro 
            260                 265                 270         


Gln Ala Val Leu Pro Pro Leu Pro Lys Arg Pro Ala Leu Glu Lys Thr 
        275                 280                 285             


Asn Gly Ala Thr Ala Val Phe Asn Thr Gly Ile Phe Gln Tyr Gln Gln 
    290                 295                 300                 


Ala Leu Ala Asn Met Gln Leu Gln Gln His Thr Ala Phe Leu Pro Pro 
305                 310                 315                 320 


Gly Ser Ile Leu Cys Met Thr Pro Ala Thr Ser Val Val Pro Met Val 
                325                 330                 335     


His Gly Ala Thr Pro Ala Thr Val Ser Ala Ala Thr Thr Ser Ala Thr 
            340                 345                 350         


Ser Val Pro Phe Ala Ala Thr Ala Thr Ala Asn Gln Ile Pro Ile Ile 
        355                 360                 365             


Ser Ala Glu His Leu Thr Ser His Lys Tyr Val Thr Gln Met 
    370                 375                 380         


<210>  8413
<211>  340
<212>  PRT
<213>  Homo Sapiens

<400>  8413

Met Ala Val Ser Val Thr Pro Ile Arg Asp Thr Lys Trp Leu Thr Leu 
1               5                   10                  15      


Glu Val Cys Arg Glu Phe Gln Arg Gly Thr Cys Ser Arg Pro Asp Thr 
            20                  25                  30          


Glu Cys Lys Phe Ala His Pro Ser Lys Ser Cys Gln Val Glu Asn Gly 
        35                  40                  45              


Arg Val Ile Ala Cys Phe Asp Ser Leu Lys Gly Arg Cys Ser Arg Glu 
    50                  55                  60                  


Asn Cys Lys Tyr Leu His Pro Pro Pro His Leu Lys Thr Gln Leu Glu 
65                  70                  75                  80  


Ile Asn Gly Arg Asn Asn Leu Ile Gln Gln Lys Asn Met Ala Met Leu 
                85                  90                  95      


Ala Gln Gln Met Gln Leu Ala Asn Ala Met Met Pro Gly Ala Pro Leu 
            100                 105                 110         


Gln Pro Val Pro Met Phe Ser Val Ala Pro Ser Leu Ala Thr Asn Ala 
        115                 120                 125             


Ser Ala Ala Ala Phe Asn Pro Tyr Leu Gly Pro Val Ser Pro Ser Leu 
    130                 135                 140                 


Val Pro Ala Glu Ile Leu Pro Thr Ala Pro Met Leu Val Thr Gly Asn 
145                 150                 155                 160 


Pro Gly Val Pro Val Pro Ala Ala Ala Ala Ala Ala Ala Gln Lys Leu 
                165                 170                 175     


Met Arg Thr Asp Arg Leu Glu Val Cys Arg Glu Tyr Gln Arg Gly Asn 
            180                 185                 190         


Cys Asn Arg Gly Glu Asn Asp Cys Arg Phe Ala His Pro Ala Asp Ser 
        195                 200                 205             


Thr Met Ile Asp Thr Asn Asp Asn Thr Val Thr Val Cys Met Asp Tyr 
    210                 215                 220                 


Ile Lys Gly Arg Cys Ser Arg Glu Lys Cys Lys Tyr Phe His Pro Pro 
225                 230                 235                 240 


Ala His Leu Gln Ala Lys Ile Lys Ala Ala Gln Tyr Gln Val Asn Gln 
                245                 250                 255     


Ala Ala Ala Ala Gln Ala Ala Ala Thr Ala Ala Ala Met Phe Pro Trp 
            260                 265                 270         


Cys Thr Val Leu Arg Gln Pro Leu Cys Pro Gln Gln Gln His Leu Pro 
        275                 280                 285             


Gln Val Phe Pro Ser Leu Gln Gln Pro Gln Pro Thr Ser Pro Ile Leu 
    290                 295                 300                 


Asp Ala Ser Thr Leu Leu Gly Ala Thr Ser Cys Pro Ala Ala Ala Gly 
305                 310                 315                 320 


Lys Met Ile Pro Ile Ile Ser Ala Glu His Leu Thr Ser His Lys Tyr 
                325                 330                 335     


Val Thr Gln Met 
            340 


<210>  8414
<211>  342
<212>  PRT
<213>  Homo Sapiens

<400>  8414

Met Ala Val Ser Val Thr Pro Ile Arg Asp Thr Lys Trp Leu Thr Leu 
1               5                   10                  15      


Glu Val Cys Arg Glu Phe Gln Arg Gly Thr Cys Ser Arg Pro Asp Thr 
            20                  25                  30          


Glu Cys Lys Phe Ala His Pro Ser Lys Ser Cys Gln Val Glu Asn Gly 
        35                  40                  45              


Arg Val Ile Ala Cys Phe Asp Ser Leu Lys Gly Arg Cys Ser Arg Glu 
    50                  55                  60                  


Asn Cys Lys Tyr Leu His Pro Pro Pro His Leu Lys Thr Gln Leu Glu 
65                  70                  75                  80  


Ile Asn Gly Arg Asn Asn Leu Ile Gln Gln Lys Asn Met Ala Met Leu 
                85                  90                  95      


Ala Gln Gln Met Gln Leu Ala Asn Ala Met Met Pro Gly Ala Pro Leu 
            100                 105                 110         


Gln Pro Val Pro Met Phe Ser Val Ala Pro Ser Leu Ala Thr Asn Ala 
        115                 120                 125             


Ser Ala Ala Ala Phe Asn Pro Tyr Leu Gly Pro Val Ser Pro Ser Leu 
    130                 135                 140                 


Val Pro Ala Glu Ile Leu Pro Thr Ala Pro Met Leu Val Thr Gly Asn 
145                 150                 155                 160 


Pro Gly Val Pro Val Pro Ala Ala Ala Ala Ala Ala Ala Gln Lys Leu 
                165                 170                 175     


Met Arg Thr Asp Arg Leu Glu Val Cys Arg Glu Tyr Gln Arg Gly Asn 
            180                 185                 190         


Cys Asn Arg Gly Glu Asn Asp Cys Arg Phe Ala His Pro Ala Asp Ser 
        195                 200                 205             


Thr Met Ile Asp Thr Asn Asp Asn Thr Val Thr Val Cys Met Asp Tyr 
    210                 215                 220                 


Ile Lys Gly Arg Cys Ser Arg Glu Lys Cys Lys Tyr Phe His Pro Pro 
225                 230                 235                 240 


Ala His Leu Gln Ala Lys Ile Lys Ala Ala Gln Tyr Gln Val Asn Gln 
                245                 250                 255     


Ala Ala Ala Ala Gln Ala Ala Ala Thr Ala Ala Ala Met Gly Ile Pro 
            260                 265                 270         


Gln Ala Val Leu Pro Pro Leu Pro Lys Arg Pro Ala Leu Glu Lys Thr 
        275                 280                 285             


Asn Gly Ala Thr Ala Val Phe Asn Thr Gly Ile Phe Gln Tyr Gln Gln 
    290                 295                 300                 


Ala Leu Ala Asn Met Gln Leu Gln Gln His Thr Ala Phe Leu Pro Pro 
305                 310                 315                 320 


Gly Ser Ile Leu Cys Met Thr Pro Ala Thr Ser Val Asp Thr His Asn 
                325                 330                 335     


Ile Cys Arg Thr Ser Asp 
            340         


<210>  8415
<211>  340
<212>  PRT
<213>  Homo Sapiens

<400>  8415

Met Ala Val Ser Val Thr Pro Ile Arg Asp Thr Lys Trp Leu Thr Leu 
1               5                   10                  15      


Glu Val Cys Arg Glu Phe Gln Arg Gly Thr Cys Ser Arg Pro Asp Thr 
            20                  25                  30          


Glu Cys Lys Phe Ala His Pro Ser Lys Ser Cys Gln Val Glu Asn Gly 
        35                  40                  45              


Arg Val Ile Ala Cys Phe Asp Ser Leu Lys Gly Arg Cys Ser Arg Glu 
    50                  55                  60                  


Asn Cys Lys Tyr Leu His Pro Pro Pro His Leu Lys Thr Gln Leu Glu 
65                  70                  75                  80  


Ile Asn Gly Arg Asn Asn Leu Ile Gln Gln Lys Asn Met Ala Met Leu 
                85                  90                  95      


Ala Gln Gln Met Gln Leu Ala Asn Ala Met Met Pro Gly Ala Pro Leu 
            100                 105                 110         


Gln Pro Val Pro Met Phe Ser Val Ala Pro Ser Leu Ala Thr Asn Ala 
        115                 120                 125             


Ser Ala Ala Ala Phe Asn Pro Tyr Leu Gly Pro Val Ser Pro Ser Leu 
    130                 135                 140                 


Val Pro Ala Glu Ile Leu Pro Thr Ala Pro Met Leu Val Thr Gly Asn 
145                 150                 155                 160 


Pro Gly Val Pro Val Pro Ala Ala Ala Ala Ala Ala Ala Gln Lys Leu 
                165                 170                 175     


Met Arg Thr Asp Arg Leu Glu Val Cys Arg Glu Tyr Gln Arg Gly Asn 
            180                 185                 190         


Cys Asn Arg Gly Glu Asn Asp Cys Arg Phe Ala His Pro Ala Asp Ser 
        195                 200                 205             


Thr Met Ile Asp Thr Asn Asp Asn Thr Val Thr Val Cys Met Asp Tyr 
    210                 215                 220                 


Ile Lys Gly Arg Cys Ser Arg Glu Lys Cys Lys Tyr Phe His Pro Pro 
225                 230                 235                 240 


Ala His Leu Gln Ala Lys Ile Lys Ala Ala Gln Tyr Gln Val Asn Gln 
                245                 250                 255     


Ala Ala Ala Ala Gln Ala Ala Ala Thr Ala Ala Ala Met Phe Pro Trp 
            260                 265                 270         


Cys Thr Val Leu Arg Gln Pro Leu Cys Pro Gln Gln Gln His Leu Pro 
        275                 280                 285             


Gln Val Phe Pro Ser Leu Gln Gln Pro Gln Pro Thr Ser Pro Ile Leu 
    290                 295                 300                 


Asp Ala Ser Thr Leu Leu Gly Ala Thr Ser Cys Pro Ala Ala Ala Gly 
305                 310                 315                 320 


Lys Met Ile Pro Ile Ile Ser Ala Glu His Leu Thr Ser His Lys Tyr 
                325                 330                 335     


Val Thr Gln Met 
            340 


<210>  8416
<211>  342
<212>  PRT
<213>  Homo Sapiens

<400>  8416

Met Ala Val Ser Val Thr Pro Ile Arg Asp Thr Lys Trp Leu Thr Leu 
1               5                   10                  15      


Glu Val Cys Arg Glu Phe Gln Arg Gly Thr Cys Ser Arg Pro Asp Thr 
            20                  25                  30          


Glu Cys Lys Phe Ala His Pro Ser Lys Ser Cys Gln Val Glu Asn Gly 
        35                  40                  45              


Arg Val Ile Ala Cys Phe Asp Ser Leu Lys Gly Arg Cys Ser Arg Glu 
    50                  55                  60                  


Asn Cys Lys Tyr Leu His Pro Pro Pro His Leu Lys Thr Gln Leu Glu 
65                  70                  75                  80  


Ile Asn Gly Arg Asn Asn Leu Ile Gln Gln Lys Asn Met Ala Met Leu 
                85                  90                  95      


Ala Gln Gln Met Gln Leu Ala Asn Ala Met Met Pro Gly Ala Pro Leu 
            100                 105                 110         


Gln Pro Val Pro Met Phe Ser Val Ala Pro Ser Leu Ala Thr Asn Ala 
        115                 120                 125             


Ser Ala Ala Ala Phe Asn Pro Tyr Leu Gly Pro Val Ser Pro Ser Leu 
    130                 135                 140                 


Val Pro Ala Glu Ile Leu Pro Thr Ala Pro Met Leu Val Thr Gly Asn 
145                 150                 155                 160 


Pro Gly Val Pro Val Pro Ala Ala Ala Ala Ala Ala Ala Gln Lys Leu 
                165                 170                 175     


Met Arg Thr Asp Arg Leu Glu Val Cys Arg Glu Tyr Gln Arg Gly Asn 
            180                 185                 190         


Cys Asn Arg Gly Glu Asn Asp Cys Arg Phe Ala His Pro Ala Asp Ser 
        195                 200                 205             


Thr Met Ile Asp Thr Asn Asp Asn Thr Val Thr Val Cys Met Asp Tyr 
    210                 215                 220                 


Ile Lys Gly Arg Cys Ser Arg Glu Lys Cys Lys Tyr Phe His Pro Pro 
225                 230                 235                 240 


Ala His Leu Gln Ala Lys Ile Lys Ala Ala Gln Tyr Gln Val Asn Gln 
                245                 250                 255     


Ala Ala Ala Ala Gln Ala Ala Ala Thr Ala Ala Ala Met Gly Ile Pro 
            260                 265                 270         


Gln Ala Val Leu Pro Pro Leu Pro Lys Arg Pro Ala Leu Glu Lys Thr 
        275                 280                 285             


Asn Gly Ala Thr Ala Val Phe Asn Thr Gly Ile Phe Gln Tyr Gln Gln 
    290                 295                 300                 


Ala Leu Ala Asn Met Gln Leu Gln Gln His Thr Ala Phe Leu Pro Pro 
305                 310                 315                 320 


Gly Ser Ile Leu Cys Met Thr Pro Ala Thr Ser Val Asp Thr His Asn 
                325                 330                 335     


Ile Cys Arg Thr Ser Asp 
            340         


<210>  8417
<211>  388
<212>  PRT
<213>  Homo Sapiens

<400>  8417

Met Ala Val Ser Val Thr Pro Ile Arg Asp Thr Lys Trp Leu Thr Leu 
1               5                   10                  15      


Glu Val Cys Arg Glu Phe Gln Arg Gly Thr Cys Ser Arg Pro Asp Thr 
            20                  25                  30          


Glu Cys Lys Phe Ala His Pro Ser Lys Ser Cys Gln Val Glu Asn Gly 
        35                  40                  45              


Arg Val Ile Ala Cys Phe Asp Ser Leu Lys Gly Arg Cys Ser Arg Glu 
    50                  55                  60                  


Asn Cys Lys Tyr Leu His Pro Pro Pro His Leu Lys Thr Gln Leu Glu 
65                  70                  75                  80  


Ile Asn Gly Arg Asn Asn Leu Ile Gln Gln Lys Asn Met Ala Met Leu 
                85                  90                  95      


Ala Gln Gln Met Gln Leu Ala Asn Ala Met Met Pro Gly Ala Pro Leu 
            100                 105                 110         


Gln Pro Val Pro Met Phe Ser Val Ala Pro Ser Leu Ala Thr Asn Ala 
        115                 120                 125             


Ser Ala Ala Ala Phe Asn Pro Tyr Leu Gly Pro Val Ser Pro Ser Leu 
    130                 135                 140                 


Val Pro Ala Glu Ile Leu Pro Thr Ala Pro Met Leu Val Thr Gly Asn 
145                 150                 155                 160 


Pro Gly Val Pro Val Pro Ala Ala Ala Ala Ala Ala Ala Gln Lys Leu 
                165                 170                 175     


Met Arg Thr Asp Arg Leu Glu Val Cys Arg Glu Tyr Gln Arg Gly Asn 
            180                 185                 190         


Cys Asn Arg Gly Glu Asn Asp Cys Arg Phe Ala His Pro Ala Asp Ser 
        195                 200                 205             


Thr Met Ile Asp Thr Asn Asp Asn Thr Val Thr Val Cys Met Asp Tyr 
    210                 215                 220                 


Ile Lys Gly Arg Cys Ser Arg Glu Lys Cys Lys Tyr Phe His Pro Pro 
225                 230                 235                 240 


Ala His Leu Gln Ala Lys Ile Lys Ala Ala Gln Tyr Gln Val Asn Gln 
                245                 250                 255     


Ala Ala Ala Ala Gln Ala Ala Ala Thr Ala Ala Ala Met Thr Gln Ser 
            260                 265                 270         


Ala Val Lys Ser Leu Lys Arg Pro Leu Glu Ala Thr Phe Asp Leu Gly 
        275                 280                 285             


Ile Pro Gln Ala Val Leu Pro Pro Leu Pro Lys Arg Pro Ala Leu Glu 
    290                 295                 300                 


Lys Thr Asn Gly Ala Thr Ala Val Phe Asn Thr Gly Ile Phe Gln Tyr 
305                 310                 315                 320 


Gln Gln Ala Leu Ala Asn Met Gln Leu Gln Gln His Thr Ala Phe Leu 
                325                 330                 335     


Pro Pro Val Pro Met Val His Gly Ala Thr Pro Ala Thr Val Ser Ala 
            340                 345                 350         


Ala Thr Thr Ser Ala Thr Ser Val Pro Phe Ala Ala Thr Ala Thr Ala 
        355                 360                 365             


Asn Gln Ile Pro Ile Ile Ser Ala Glu His Leu Thr Ser His Lys Tyr 
    370                 375                 380                 


Val Thr Gln Met 
385             


<210>  8418
<211>  348
<212>  PRT
<213>  Homo Sapiens

<400>  8418

Met Ala Val Ser Val Thr Pro Ile Arg Asp Thr Lys Trp Leu Thr Leu 
1               5                   10                  15      


Glu Val Cys Arg Glu Phe Gln Arg Gly Thr Cys Ser Arg Pro Asp Thr 
            20                  25                  30          


Glu Cys Lys Phe Ala His Pro Ser Lys Ser Cys Gln Val Glu Asn Gly 
        35                  40                  45              


Arg Val Ile Ala Cys Phe Asp Ser Leu Lys Gly Arg Cys Ser Arg Glu 
    50                  55                  60                  


Asn Cys Lys Tyr Leu His Pro Pro Pro His Leu Lys Thr Gln Leu Glu 
65                  70                  75                  80  


Ile Asn Gly Arg Asn Asn Leu Ile Gln Gln Lys Asn Met Ala Met Leu 
                85                  90                  95      


Ala Gln Gln Met Gln Leu Ala Asn Ala Met Met Pro Gly Ala Pro Leu 
            100                 105                 110         


Gln Pro Val Pro Met Phe Ser Val Ala Pro Ser Leu Ala Thr Asn Ala 
        115                 120                 125             


Ser Ala Ala Ala Phe Asn Pro Tyr Leu Gly Pro Val Ser Pro Ser Leu 
    130                 135                 140                 


Val Pro Ala Glu Ile Leu Pro Thr Ala Pro Met Leu Val Thr Gly Asn 
145                 150                 155                 160 


Pro Gly Val Pro Val Pro Ala Ala Ala Ala Ala Ala Ala Gln Lys Leu 
                165                 170                 175     


Met Arg Thr Asp Arg Leu Glu Val Cys Arg Glu Tyr Gln Arg Gly Asn 
            180                 185                 190         


Cys Asn Arg Gly Glu Asn Asp Cys Arg Phe Ala His Pro Ala Asp Ser 
        195                 200                 205             


Thr Met Ile Asp Thr Asn Asp Asn Thr Val Thr Val Cys Met Asp Tyr 
    210                 215                 220                 


Ile Lys Gly Arg Cys Ser Arg Glu Lys Cys Lys Tyr Phe His Pro Pro 
225                 230                 235                 240 


Ala His Leu Gln Ala Lys Ile Lys Ala Ala Gln Tyr Gln Val Asn Gln 
                245                 250                 255     


Ala Ala Ala Ala Gln Ala Ala Ala Thr Ala Ala Ala Met Thr Gln Ser 
            260                 265                 270         


Ala Val Lys Ser Leu Lys Arg Pro Leu Glu Ala Thr Phe Asp Leu Gly 
        275                 280                 285             


Ile Pro Gln Ala Val Leu Pro Pro Leu Pro Lys Arg Pro Ala Leu Glu 
    290                 295                 300                 


Lys Thr Asn Gly Ala Thr Ala Val Phe Asn Thr Gly Ile Phe Gln Tyr 
305                 310                 315                 320 


Gln Gln Ala Leu Ala Asn Met Gln Leu Gln Gln His Thr Ala Phe Leu 
                325                 330                 335     


Pro Pro Asp Thr His Asn Ile Cys Arg Thr Ser Asp 
            340                 345             


<210>  8419
<211>  314
<212>  PRT
<213>  Homo Sapiens

<400>  8419

Met Ala Val Ser Val Thr Pro Ile Arg Asp Thr Lys Trp Leu Thr Leu 
1               5                   10                  15      


Glu Val Cys Arg Glu Phe Gln Arg Gly Thr Cys Ser Arg Pro Asp Thr 
            20                  25                  30          


Glu Cys Lys Phe Ala His Pro Ser Lys Ser Cys Gln Val Glu Asn Gly 
        35                  40                  45              


Arg Val Ile Ala Cys Phe Asp Ser Leu Lys Gly Arg Cys Ser Arg Glu 
    50                  55                  60                  


Asn Cys Lys Tyr Leu His Pro Pro Pro His Leu Lys Thr Gln Leu Glu 
65                  70                  75                  80  


Ile Asn Gly Arg Asn Asn Leu Ile Gln Gln Lys Asn Met Ala Met Leu 
                85                  90                  95      


Ala Gln Gln Met Gln Leu Ala Asn Ala Met Met Pro Gly Ala Pro Leu 
            100                 105                 110         


Gln Pro Val Val Cys Arg Glu Tyr Gln Arg Gly Asn Cys Asn Arg Gly 
        115                 120                 125             


Glu Asn Asp Cys Arg Phe Ala His Pro Ala Asp Ser Thr Met Ile Asp 
    130                 135                 140                 


Thr Asn Asp Asn Thr Val Thr Val Cys Met Asp Tyr Ile Lys Gly Arg 
145                 150                 155                 160 


Cys Ser Arg Glu Lys Cys Lys Tyr Phe His Pro Pro Ala His Leu Gln 
                165                 170                 175     


Ala Lys Ile Lys Ala Ala Gln Tyr Gln Val Asn Gln Ala Ala Ala Ala 
            180                 185                 190         


Gln Ala Ala Ala Thr Ala Ala Ala Met Gly Ile Pro Gln Ala Val Leu 
        195                 200                 205             


Pro Pro Leu Pro Lys Arg Pro Ala Leu Glu Lys Thr Asn Gly Ala Thr 
    210                 215                 220                 


Ala Val Phe Asn Thr Gly Ile Phe Gln Tyr Gln Gln Ala Leu Ala Asn 
225                 230                 235                 240 


Met Gln Leu Gln Gln His Thr Ala Phe Leu Pro Pro Gly Ser Ile Leu 
                245                 250                 255     


Cys Met Thr Pro Ala Thr Ser Val Val Pro Met Val His Gly Ala Thr 
            260                 265                 270         


Pro Ala Thr Val Ser Ala Ala Thr Thr Ser Ala Thr Ser Val Pro Phe 
        275                 280                 285             


Ala Ala Thr Ala Thr Ala Asn Gln Ile Pro Ile Ile Ser Ala Glu His 
    290                 295                 300                 


Leu Thr Ser His Lys Tyr Val Thr Gln Met 
305                 310                 


<210>  8420
<211>  314
<212>  PRT
<213>  Homo Sapiens

<400>  8420

Met Ala Val Ser Val Thr Pro Ile Arg Asp Thr Lys Trp Leu Thr Leu 
1               5                   10                  15      


Glu Val Cys Arg Glu Phe Gln Arg Gly Thr Cys Ser Arg Pro Asp Thr 
            20                  25                  30          


Glu Cys Lys Phe Ala His Pro Ser Lys Ser Cys Gln Val Glu Asn Gly 
        35                  40                  45              


Arg Val Ile Ala Cys Phe Asp Ser Leu Lys Gly Arg Cys Ser Arg Glu 
    50                  55                  60                  


Asn Cys Lys Tyr Leu His Pro Pro Pro His Leu Lys Thr Gln Leu Glu 
65                  70                  75                  80  


Ile Asn Gly Arg Asn Asn Leu Ile Gln Gln Lys Asn Met Ala Met Leu 
                85                  90                  95      


Ala Gln Gln Met Gln Leu Ala Asn Ala Met Met Pro Gly Ala Pro Leu 
            100                 105                 110         


Gln Pro Val Val Cys Arg Glu Tyr Gln Arg Gly Asn Cys Asn Arg Gly 
        115                 120                 125             


Glu Asn Asp Cys Arg Phe Ala His Pro Ala Asp Ser Thr Met Ile Asp 
    130                 135                 140                 


Thr Asn Asp Asn Thr Val Thr Val Cys Met Asp Tyr Ile Lys Gly Arg 
145                 150                 155                 160 


Cys Ser Arg Glu Lys Cys Lys Tyr Phe His Pro Pro Ala His Leu Gln 
                165                 170                 175     


Ala Lys Ile Lys Ala Ala Gln Tyr Gln Val Asn Gln Ala Ala Ala Ala 
            180                 185                 190         


Gln Ala Ala Ala Thr Ala Ala Ala Met Gly Ile Pro Gln Ala Val Leu 
        195                 200                 205             


Pro Pro Leu Pro Lys Arg Pro Ala Leu Glu Lys Thr Asn Gly Ala Thr 
    210                 215                 220                 


Ala Val Phe Asn Thr Gly Ile Phe Gln Tyr Gln Gln Ala Leu Ala Asn 
225                 230                 235                 240 


Met Gln Leu Gln Gln His Thr Ala Phe Leu Pro Pro Gly Ser Ile Leu 
                245                 250                 255     


Cys Met Thr Pro Ala Thr Ser Val Val Pro Met Val His Gly Ala Thr 
            260                 265                 270         


Pro Ala Thr Val Ser Ala Ala Thr Thr Ser Ala Thr Ser Val Pro Phe 
        275                 280                 285             


Ala Ala Thr Ala Thr Ala Asn Gln Ile Pro Ile Ile Ser Ala Glu His 
    290                 295                 300                 


Leu Thr Ser His Lys Tyr Val Thr Gln Met 
305                 310                 


<210>  8421
<211>  302
<212>  PRT
<213>  Homo Sapiens

<400>  8421

Met Ala Val Ser Val Thr Pro Ile Arg Asp Thr Lys Trp Leu Thr Leu 
1               5                   10                  15      


Glu Val Cys Arg Glu Phe Gln Arg Gly Thr Cys Ser Arg Pro Asp Thr 
            20                  25                  30          


Glu Cys Lys Phe Ala His Pro Ser Lys Ser Cys Gln Val Glu Asn Gly 
        35                  40                  45              


Arg Val Ile Ala Cys Phe Asp Ser Leu Lys Gly Arg Cys Ser Arg Glu 
    50                  55                  60                  


Asn Cys Lys Tyr Leu His Pro Pro Pro His Leu Lys Thr Gln Leu Glu 
65                  70                  75                  80  


Ile Asn Gly Arg Asn Asn Leu Ile Gln Gln Lys Asn Met Ala Met Leu 
                85                  90                  95      


Ala Gln Gln Met Gln Leu Ala Asn Ala Met Met Pro Gly Ala Pro Leu 
            100                 105                 110         


Gln Pro Val Val Cys Arg Glu Tyr Gln Arg Gly Asn Cys Asn Arg Gly 
        115                 120                 125             


Glu Asn Asp Cys Arg Phe Ala His Pro Ala Asp Ser Thr Met Ile Asp 
    130                 135                 140                 


Thr Asn Asp Asn Thr Val Thr Val Cys Met Asp Tyr Ile Lys Gly Arg 
145                 150                 155                 160 


Cys Ser Arg Glu Lys Cys Lys Tyr Phe His Pro Pro Ala His Leu Gln 
                165                 170                 175     


Ala Lys Ile Lys Ala Ala Gln Tyr Gln Val Asn Gln Ala Ala Ala Ala 
            180                 185                 190         


Gln Ala Ala Ala Thr Ala Ala Ala Met Gly Ile Pro Gln Ala Val Leu 
        195                 200                 205             


Pro Pro Leu Pro Lys Arg Pro Ala Leu Glu Lys Thr Asn Gly Ala Thr 
    210                 215                 220                 


Ala Val Phe Asn Thr Gly Ile Phe Gln Tyr Gln Gln Ala Leu Ala Asn 
225                 230                 235                 240 


Met Gln Leu Gln Gln His Thr Ala Phe Leu Pro Pro Val Pro Met Val 
                245                 250                 255     


His Gly Ala Thr Pro Ala Thr Val Ser Ala Ala Thr Thr Ser Ala Thr 
            260                 265                 270         


Ser Val Pro Phe Ala Ala Thr Ala Thr Ala Asn Gln Ile Pro Ile Ile 
        275                 280                 285             


Ser Ala Glu His Leu Thr Ser His Lys Tyr Val Thr Gln Met 
    290                 295                 300         


<210>  8422
<211>  343
<212>  PRT
<213>  Homo Sapiens

<400>  8422

Met Gly Arg Cys Ser Arg Glu Asn Cys Lys Tyr Leu His Pro Pro Pro 
1               5                   10                  15      


His Leu Lys Thr Gln Leu Glu Ile Asn Gly Arg Asn Asn Leu Ile Gln 
            20                  25                  30          


Gln Lys Asn Met Ala Met Leu Ala Gln Gln Met Gln Leu Ala Asn Ala 
        35                  40                  45              


Met Met Pro Gly Ala Pro Leu Gln Pro Val Pro Met Phe Ser Val Ala 
    50                  55                  60                  


Pro Ser Leu Ala Thr Asn Ala Ser Ala Ala Ala Phe Asn Pro Tyr Leu 
65                  70                  75                  80  


Gly Pro Val Ser Pro Ser Leu Val Pro Ala Glu Ile Leu Pro Thr Ala 
                85                  90                  95      


Pro Met Leu Val Thr Gly Asn Pro Gly Val Pro Val Pro Ala Ala Ala 
            100                 105                 110         


Ala Ala Ala Ala Gln Lys Leu Met Arg Thr Asp Arg Leu Glu Val Cys 
        115                 120                 125             


Arg Glu Tyr Gln Arg Gly Asn Cys Asn Arg Gly Glu Asn Asp Cys Arg 
    130                 135                 140                 


Phe Ala His Pro Ala Asp Ser Thr Met Ile Asp Thr Asn Asp Asn Thr 
145                 150                 155                 160 


Val Thr Val Cys Met Asp Tyr Ile Lys Gly Arg Cys Ser Arg Glu Lys 
                165                 170                 175     


Cys Lys Tyr Phe His Pro Pro Ala His Leu Gln Ala Lys Ile Lys Ala 
            180                 185                 190         


Ala Gln Tyr Gln Val Asn Gln Ala Ala Ala Ala Gln Ala Ala Ala Thr 
        195                 200                 205             


Ala Ala Ala Met Thr Gln Ser Ala Val Lys Ser Leu Lys Arg Pro Leu 
    210                 215                 220                 


Glu Ala Thr Phe Asp Leu Gly Ile Pro Gln Ala Val Leu Pro Pro Leu 
225                 230                 235                 240 


Pro Lys Arg Pro Ala Leu Glu Lys Thr Asn Gly Ala Thr Ala Val Phe 
                245                 250                 255     


Asn Thr Gly Ile Phe Gln Tyr Gln Gln Ala Leu Ala Asn Met Gln Leu 
            260                 265                 270         


Gln Gln His Thr Ala Phe Leu Pro Pro Gly Ser Ile Leu Cys Met Thr 
        275                 280                 285             


Pro Ala Thr Ser Val Val Pro Met Val His Gly Ala Thr Pro Ala Thr 
    290                 295                 300                 


Val Ser Ala Ala Thr Thr Ser Ala Thr Ser Val Pro Phe Ala Ala Thr 
305                 310                 315                 320 


Ala Thr Ala Asn Gln Ile Pro Ile Ile Ser Ala Glu His Leu Thr Ser 
                325                 330                 335     


His Lys Tyr Val Thr Gln Met 
            340             


<210>  8423
<211>  58
<212>  PRT
<213>  Homo Sapiens

<400>  8423

Met Leu Gly Arg Cys Ser Arg Glu Asn Cys Lys Tyr Leu His Pro Pro 
1               5                   10                  15      


Pro His Leu Lys Thr Gln Leu Glu Ile Asn Gly Arg Asn Asn Leu Ile 
            20                  25                  30          


Gln Gln Lys Asn Met Ala Met Leu Ala Gln Gln Met Gln Leu Ala Asn 
        35                  40                  45              


Ala Met Met Pro Gly Ala Pro Leu Gln Pro 
    50                  55              


<210>  8424
<211>  210
<212>  PRT
<213>  Homo Sapiens

<400>  8424

Gln Gln Met Gln Leu Ala Asn Ala Met Met Pro Gly Ala Pro Leu Gln 
1               5                   10                  15      


Pro Val Pro Met Phe Ser Val Ala Pro Ser Leu Ala Thr Asn Ala Ser 
            20                  25                  30          


Ala Ala Ala Phe Asn Pro Tyr Leu Gly Pro Val Ser Pro Ser Leu Val 
        35                  40                  45              


Pro Ala Glu Ile Leu Pro Thr Ala Pro Met Leu Val Thr Gly Asn Pro 
    50                  55                  60                  


Gly Val Pro Val Pro Ala Ala Ala Ala Ala Ala Ala Gln Lys Leu Met 
65                  70                  75                  80  


Arg Thr Asp Arg Leu Glu Val Cys Arg Glu Tyr Gln Arg Gly Asn Cys 
                85                  90                  95      


Asn Arg Gly Glu Asn Asp Cys Arg Phe Ala His Pro Ala Asp Ser Thr 
            100                 105                 110         


Met Ile Asp Thr Asn Asp Asn Thr Val Thr Val Cys Met Asp Tyr Ile 
        115                 120                 125             


Lys Gly Arg Cys Ser Arg Glu Lys Cys Lys Tyr Phe His Pro Pro Ala 
    130                 135                 140                 


His Leu Gln Ala Lys Ile Lys Ala Ala Gln Tyr Gln Val Asn Gln Ala 
145                 150                 155                 160 


Ala Ala Ala Gln Ala Ala Ala Thr Ala Ala Ala Met Ala Leu Ala Asn 
                165                 170                 175     


Met Gln Leu Gln Gln His Thr Ala Phe Leu Pro Pro Gly Ser Ile Leu 
            180                 185                 190         


Cys Met Thr Pro Ala Thr Ser Val Asp Thr His Asn Ile Cys Arg Thr 
        195                 200                 205             


Ser Asp 
    210 


<210>  8425
<211>  329
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8425

Xaa Val Ser Val Thr Pro Ile Arg Asp Thr Lys Trp Leu Thr Leu Glu 
1               5                   10                  15      


Val Cys Arg Glu Phe Gln Arg Gly Thr Cys Ser Arg Pro Asp Thr Glu 
            20                  25                  30          


Cys Lys Phe Ala His Pro Ser Lys Ser Cys Gln Val Glu Asn Gly Arg 
        35                  40                  45              


Val Ile Ala Cys Phe Asp Ser Leu Lys Gly Arg Cys Ser Arg Glu Asn 
    50                  55                  60                  


Cys Lys Tyr Leu His Pro Pro Pro His Leu Lys Thr Gln Leu Glu Ile 
65                  70                  75                  80  


Asn Gly Arg Asn Asn Leu Ile Gln Gln Lys Asn Met Ala Met Leu Ala 
                85                  90                  95      


Gln Gln Met Gln Leu Ala Asn Ala Met Met Pro Gly Ala Pro Leu Gln 
            100                 105                 110         


Pro Val Pro Met Phe Ser Val Ala Pro Ser Leu Ala Thr Asn Ala Ser 
        115                 120                 125             


Ala Ala Ala Phe Asn Pro Tyr Leu Gly Pro Val Ser Pro Ser Leu Val 
    130                 135                 140                 


Pro Ala Glu Ile Leu Pro Thr Ala Pro Met Leu Val Thr Gly Asn Pro 
145                 150                 155                 160 


Gly Val Pro Val Pro Ala Ala Ala Ala Ala Ala Ala Gln Lys Leu Met 
                165                 170                 175     


Arg Thr Asp Arg Leu Glu Val Cys Arg Glu Tyr Gln Arg Gly Asn Cys 
            180                 185                 190         


Asn Arg Gly Glu Asn Asp Cys Arg Phe Ala His Pro Ala Asp Ser Thr 
        195                 200                 205             


Met Ile Asp Thr Asn Asp Asn Thr Val Thr Val Cys Met Asp Tyr Ile 
    210                 215                 220                 


Lys Gly Arg Cys Ser Arg Glu Lys Cys Lys Tyr Phe His Pro Pro Ala 
225                 230                 235                 240 


His Leu Gln Ala Lys Ile Lys Ala Ala Gln Tyr Gln Val Asn Gln Ala 
                245                 250                 255     


Ala Ala Ala Gln Ala Ala Ala Thr Ala Ala Ala Met Gly Ile Pro Gln 
            260                 265                 270         


Ala Val Leu Pro Pro Leu Pro Lys Arg Pro Ala Leu Glu Lys Thr Asn 
        275                 280                 285             


Gly Ala Thr Ala Val Phe Asn Thr Gly Ile Phe Gln Tyr Gln Gln Ala 
    290                 295                 300                 


Leu Ala Asn Met Gln Leu Gln Gln His Thr Ala Phe Leu Pro Pro Asp 
305                 310                 315                 320 


Thr His Asn Ile Cys Arg Thr Ser Asp 
                325                 


<210>  8426
<211>  56
<212>  PRT
<213>  Homo Sapiens

<400>  8426

Met Ala Ala Ala Ser Ala Val Ser Val Leu Leu Val Ala Ala Glu Arg 
1               5                   10                  15      


Asn Arg Trp His Arg Leu Pro Ser Leu Leu Leu Pro Pro Arg Leu Ser 
            20                  25                  30          


Ile Gln Asp Ala Val Phe Ser Gln Lys Thr Trp Asn Leu Leu Asn Phe 
        35                  40                  45              


Val Ser Lys Lys Glu Leu Phe Leu 
    50                  55      


<210>  8427
<211>  598
<212>  PRT
<213>  Homo Sapiens

<400>  8427

Met Ala Ala Ala Ser Ala Val Ser Val Leu Leu Val Ala Ala Glu Arg 
1               5                   10                  15      


Asn Arg Trp His Arg Leu Pro Ser Leu Leu Leu Pro Pro Arg Thr Trp 
            20                  25                  30          


Val Trp Arg Gln Arg Thr Met Lys Tyr Thr Thr Ala Thr Asp Glu Ala 
        35                  40                  45              


Tyr Ser Ile Gly Pro Ala Pro Ser Gln Gln Ser Tyr Leu Ser Met Glu 
    50                  55                  60                  


Lys Ile Ile Gln Val Ala Lys Thr Ser Ala Ala Gln Ala Ile His Pro 
65                  70                  75                  80  


Gly Cys Gly Phe Leu Ser Glu Asn Met Glu Phe Ala Glu Leu Cys Lys 
                85                  90                  95      


Gln Glu Gly Ile Ile Phe Ile Gly Pro Pro Pro Ser Ala Ile Arg Asp 
            100                 105                 110         


Met Gly Ile Lys Ser Thr Ser Lys Ser Ile Met Ala Ala Ala Gly Val 
        115                 120                 125             


Pro Val Val Glu Gly Tyr His Gly Glu Asp Gln Ser Asp Gln Cys Leu 
    130                 135                 140                 


Lys Glu His Ala Arg Arg Ile Gly Tyr Pro Val Met Ile Lys Ala Val 
145                 150                 155                 160 


Arg Gly Gly Gly Gly Lys Gly Met Arg Ile Val Arg Ser Glu Gln Glu 
                165                 170                 175     


Phe Gln Glu Gln Leu Glu Ser Ala Arg Arg Glu Ala Lys Lys Ser Phe 
            180                 185                 190         


Asn Asp Asp Ala Met Leu Ile Glu Lys Phe Val Asp Thr Pro Arg His 
        195                 200                 205             


Val Glu Val Gln Val Phe Gly Asp His His Gly Asn Ala Val Tyr Leu 
    210                 215                 220                 


Phe Glu Arg Asp Cys Ser Val Gln Arg Arg His Gln Lys Ile Ile Glu 
225                 230                 235                 240 


Glu Ala Pro Ala Pro Gly Ile Lys Ser Glu Val Arg Lys Lys Leu Gly 
                245                 250                 255     


Glu Ala Ala Val Arg Ala Ala Lys Ala Val Asn Tyr Val Gly Ala Gly 
            260                 265                 270         


Thr Val Glu Phe Ile Met Asp Ser Lys His Asn Phe Cys Phe Met Glu 
        275                 280                 285             


Met Asn Thr Arg Leu Gln Val Glu His Pro Val Thr Glu Met Ile Thr 
    290                 295                 300                 


Gly Thr Asp Leu Val Glu Trp Gln Leu Arg Ile Ala Ala Gly Glu Lys 
305                 310                 315                 320 


Ile Pro Leu Ser Gln Glu Glu Ile Thr Leu Gln Gly His Ala Phe Glu 
                325                 330                 335     


Ala Arg Ile Tyr Ala Glu Asp Pro Ser Asn Asn Phe Met Pro Val Ala 
            340                 345                 350         


Gly Pro Leu Val His Leu Ser Thr Pro Arg Ala Asp Pro Ser Thr Arg 
        355                 360                 365             


Ile Glu Thr Gly Val Arg Gln Gly Asp Glu Val Ser Val His Tyr Asp 
    370                 375                 380                 


Pro Met Ile Ala Lys Leu Val Val Trp Ala Ala Asp Arg Gln Ala Ala 
385                 390                 395                 400 


Leu Thr Lys Leu Arg Tyr Ser Leu Arg Gln Tyr Asn Ile Val Gly Leu 
                405                 410                 415     


His Thr Asn Ile Asp Phe Leu Leu Asn Leu Ser Gly His Pro Glu Phe 
            420                 425                 430         


Glu Ala Gly Asn Val His Thr Asp Phe Ile Pro Gln His His Lys Gln 
        435                 440                 445             


Leu Leu Leu Ser Arg Lys Ala Ala Ala Lys Glu Ser Leu Cys Gln Ala 
    450                 455                 460                 


Ala Leu Gly Leu Ile Leu Lys Glu Lys Ala Met Thr Asp Thr Phe Thr 
465                 470                 475                 480 


Leu Gln Ala His Asp Gln Phe Ser Pro Phe Ser Ser Ser Ser Gly Arg 
                485                 490                 495     


Arg Leu Asn Ile Ser Tyr Thr Arg Asn Met Thr Leu Lys Asp Gly Lys 
            500                 505                 510         


Asn Asn Val Ala Ile Ala Val Thr Tyr Asn His Asp Gly Ser Tyr Ser 
        515                 520                 525             


Met Gln Ile Glu Asp Lys Thr Phe Gln Val Leu Gly Asn Leu Tyr Ser 
    530                 535                 540                 


Glu Gly Asp Cys Thr Tyr Leu Lys Cys Ser Val Asn Gly Val Ala Ser 
545                 550                 555                 560 


Lys Ala Lys Leu Ile Ile Leu Glu Asn Thr Ile Tyr Leu Phe Ser Lys 
                565                 570                 575     


Glu Gly Ser Ile Glu Ile Asp Ile Pro Val Pro Lys Tyr Leu Ser Ser 
            580                 585                 590         


Val Ser Ser Gln Glu Thr 
        595             


<210>  8428
<211>  47
<212>  PRT
<213>  Homo Sapiens

<400>  8428

Met Ala Ala Ala Ser Ala Val Ser Val Leu Leu Val Ala Ala Glu Arg 
1               5                   10                  15      


Asn Arg Trp His Arg Leu Pro Ser Leu Leu Leu Pro Pro Arg Thr Trp 
            20                  25                  30          


Val Trp Arg Gln Arg Thr Met Lys Tyr Thr Thr Ala Thr Gly Arg 
        35                  40                  45          


<210>  8429
<211>  47
<212>  PRT
<213>  Homo Sapiens

<400>  8429

Met Ala Ala Ala Ser Ala Val Ser Val Leu Leu Val Ala Ala Glu Arg 
1               5                   10                  15      


Asn Arg Trp His Arg Leu Pro Ser Leu Leu Leu Pro Pro Arg Thr Trp 
            20                  25                  30          


Val Trp Arg Gln Arg Thr Met Lys Tyr Thr Thr Ala Thr Gly Arg 
        35                  40                  45          


<210>  8430
<211>  725
<212>  PRT
<213>  Homo Sapiens

<400>  8430

Met Ala Ala Ala Ser Ala Val Ser Val Leu Leu Val Ala Ala Glu Arg 
1               5                   10                  15      


Asn Arg Trp His Arg Leu Pro Ser Leu Leu Leu Pro Pro Arg Thr Trp 
            20                  25                  30          


Val Trp Arg Gln Arg Thr Met Lys Tyr Thr Thr Ala Thr Gly Arg Asn 
        35                  40                  45              


Ile Thr Lys Val Leu Ile Ala Asn Arg Gly Glu Ile Ala Cys Arg Val 
    50                  55                  60                  


Met Arg Thr Ala Lys Lys Leu Gly Val Gln Thr Val Ala Val Tyr Ser 
65                  70                  75                  80  


Glu Ala Asp Arg Asn Ser Met His Val Asp Met Ala Asp Glu Ala Tyr 
                85                  90                  95      


Ser Ile Gly Pro Ala Pro Ser Gln Gln Ser Tyr Leu Ser Met Glu Lys 
            100                 105                 110         


Ile Ile Gln Val Ala Lys Thr Ser Ala Ala Gln Ala Ile His Pro Gly 
        115                 120                 125             


Cys Gly Phe Leu Ser Glu Asn Met Glu Phe Ala Glu Leu Cys Lys Gln 
    130                 135                 140                 


Glu Gly Ile Ile Phe Ile Gly Pro Pro Pro Ser Ala Ile Arg Asp Met 
145                 150                 155                 160 


Gly Ile Lys Ser Thr Ser Lys Ser Ile Met Ala Ala Ala Gly Val Pro 
                165                 170                 175     


Val Val Glu Gly Tyr His Gly Glu Asp Gln Ser Asp Gln Cys Leu Lys 
            180                 185                 190         


Glu His Ala Arg Arg Ile Gly Tyr Pro Val Met Ile Lys Ala Val Arg 
        195                 200                 205             


Gly Gly Gly Gly Lys Gly Met Arg Ile Val Arg Ser Glu Gln Glu Phe 
    210                 215                 220                 


Gln Glu Gln Leu Glu Ser Ala Arg Arg Glu Ala Lys Lys Ser Phe Asn 
225                 230                 235                 240 


Asp Asp Ala Met Leu Ile Glu Lys Phe Val Asp Thr Pro Arg His Val 
                245                 250                 255     


Glu Val Gln Val Phe Gly Asp His His Gly Asn Ala Val Tyr Leu Phe 
            260                 265                 270         


Glu Arg Asp Cys Ser Val Gln Arg Arg His Gln Lys Ile Ile Glu Glu 
        275                 280                 285             


Ala Pro Ala Pro Gly Ile Lys Ser Glu Val Arg Lys Lys Leu Gly Glu 
    290                 295                 300                 


Ala Ala Val Arg Ala Ala Lys Ala Val Asn Tyr Val Gly Ala Gly Thr 
305                 310                 315                 320 


Val Glu Phe Ile Met Asp Ser Lys His Asn Phe Cys Phe Met Glu Met 
                325                 330                 335     


Asn Thr Arg Leu Gln Val Glu His Pro Val Thr Glu Met Ile Thr Gly 
            340                 345                 350         


Thr Asp Leu Val Glu Trp Gln Leu Arg Ile Ala Ala Gly Glu Lys Ile 
        355                 360                 365             


Pro Leu Ser Gln Glu Glu Ile Thr Leu Gln Gly His Ala Phe Glu Ala 
    370                 375                 380                 


Arg Ile Tyr Ala Glu Asp Pro Ser Asn Asn Phe Met Pro Val Ala Gly 
385                 390                 395                 400 


Pro Leu Val His Leu Ser Thr Pro Arg Ala Asp Pro Ser Thr Arg Ile 
                405                 410                 415     


Glu Thr Gly Val Arg Gln Gly Asp Glu Val Ser Val His Tyr Asp Pro 
            420                 425                 430         


Met Ile Ala Lys Leu Val Val Trp Ala Ala Asp Arg Gln Ala Ala Leu 
        435                 440                 445             


Thr Lys Leu Arg Tyr Ser Leu Arg Gln Tyr Asn Ile Val Gly Leu His 
    450                 455                 460                 


Thr Asn Ile Asp Phe Leu Leu Asn Leu Ser Gly His Pro Glu Phe Glu 
465                 470                 475                 480 


Ala Gly Asn Val His Thr Asp Phe Ile Pro Gln His His Lys Gln Leu 
                485                 490                 495     


Leu Leu Ser Arg Lys Ala Ala Ala Lys Glu Ser Leu Cys Gln Ala Ala 
            500                 505                 510         


Leu Gly Leu Ile Leu Lys Glu Lys Ala Met Thr Asp Thr Phe Thr Leu 
        515                 520                 525             


Gln Ala His Asp Gln Phe Ser Pro Phe Ser Ser Ser Ser Gly Arg Arg 
    530                 535                 540                 


Leu Asn Ile Ser Tyr Thr Arg Asn Met Thr Leu Lys Asp Gly Lys Asn 
545                 550                 555                 560 


Asn Val Ala Ile Ala Val Thr Tyr Asn His Asp Gly Ser Tyr Ser Met 
                565                 570                 575     


Gln Ile Glu Asp Lys Thr Phe Gln Val Leu Gly Asn Leu Tyr Ser Glu 
            580                 585                 590         


Gly Asp Cys Thr Tyr Leu Lys Cys Ser Val Asn Gly Val Ala Ser Lys 
        595                 600                 605             


Ala Lys Leu Ile Ile Leu Glu Asn Thr Ile Tyr Leu Phe Ser Lys Glu 
    610                 615                 620                 


Gly Ser Ile Glu Ile Asp Ile Pro Val Pro Lys Tyr Leu Ser Ser Val 
625                 630                 635                 640 


Ser Ser Gln Glu Thr Gln Gly Gly Pro Leu Ala Pro Met Thr Gly Thr 
                645                 650                 655     


Ile Glu Lys Val Phe Val Lys Ala Gly Asp Lys Val Lys Ala Gly Asp 
            660                 665                 670         


Ser Leu Met Val Met Ile Ala Met Lys Met Glu His Thr Ile Lys Ser 
        675                 680                 685             


Pro Lys Asp Gly Thr Val Lys Lys Val Phe Tyr Arg Glu Gly Ala Gln 
    690                 695                 700                 


Ala Asn Arg His Thr Pro Leu Val Glu Phe Glu Glu Glu Glu Ser Asp 
705                 710                 715                 720 


Lys Arg Glu Ser Glu 
                725 


<210>  8431
<211>  112
<212>  PRT
<213>  Homo Sapiens

<400>  8431

Met Ala Ala Ala Ser Ala Val Ser Val Leu Leu Val Ala Ala Glu Arg 
1               5                   10                  15      


Asn Arg Trp His Arg Leu Pro Ser Leu Leu Leu Pro Pro Arg Thr Trp 
            20                  25                  30          


Val Trp Arg Gln Arg Thr Met Lys Tyr Thr Thr Ala Thr Gly Arg Asn 
        35                  40                  45              


Ile Thr Lys Val Leu Ile Ala Asn Arg Gly Glu Ile Ala Cys Arg Val 
    50                  55                  60                  


Met Arg Thr Ala Lys Lys Leu Gly Val Gln Thr Val Ala Val Tyr Ser 
65                  70                  75                  80  


Glu Ala Asp Arg Asn Ser Met His Val Asp Met Gln Asp Asp Leu Asp 
                85                  90                  95      


Phe Thr Glu Lys Ile Lys Leu Arg Phe Leu Pro Gln Asn Leu Leu Thr 
            100                 105                 110         


<210>  8432
<211>  61
<212>  PRT
<213>  Homo Sapiens

<400>  8432

Met Ala Ala Ala Ser Ala Val Ser Val Leu Leu Val Ala Ala Glu Arg 
1               5                   10                  15      


Asn Arg Trp His Arg Leu Pro Ser Leu Leu Leu Pro Pro Arg Thr Trp 
            20                  25                  30          


Val Trp Arg Gln Arg Thr Met Lys Tyr Thr Thr Ala Thr Gly Tyr Pro 
        35                  40                  45              


Ser Arg Met Arg Phe Ser Leu Arg Lys His Gly Ile Cys 
    50                  55                  60      


<210>  8433
<211>  61
<212>  PRT
<213>  Homo Sapiens

<400>  8433

Met Ala Ala Ala Ser Ala Val Ser Val Leu Leu Val Ala Ala Glu Arg 
1               5                   10                  15      


Asn Arg Trp His Arg Leu Pro Ser Leu Leu Leu Pro Pro Arg Thr Trp 
            20                  25                  30          


Val Trp Arg Gln Arg Thr Met Lys Tyr Thr Thr Ala Thr Gly Tyr Pro 
        35                  40                  45              


Ser Arg Met Arg Phe Ser Leu Arg Lys His Gly Ile Cys 
    50                  55                  60      


<210>  8434
<211>  616
<212>  PRT
<213>  Homo Sapiens

<400>  8434

Met Glu Lys Ile Ile Gln Val Ala Lys Thr Ser Ala Ala Gln Ala Ile 
1               5                   10                  15      


His Pro Gly Cys Gly Phe Leu Ser Glu Asn Met Glu Phe Ala Glu Leu 
            20                  25                  30          


Cys Lys Gln Glu Gly Ile Ile Phe Ile Gly Pro Pro Pro Ser Ala Ile 
        35                  40                  45              


Arg Asp Met Gly Ile Lys Ser Thr Ser Lys Ser Ile Met Ala Ala Ala 
    50                  55                  60                  


Gly Val Pro Val Val Glu Gly Tyr His Gly Glu Asp Gln Ser Asp Gln 
65                  70                  75                  80  


Cys Leu Lys Glu His Ala Arg Arg Ile Gly Tyr Pro Val Met Ile Lys 
                85                  90                  95      


Ala Val Arg Gly Gly Gly Gly Lys Gly Met Arg Ile Val Arg Ser Glu 
            100                 105                 110         


Gln Glu Phe Gln Glu Gln Leu Glu Ser Ala Arg Arg Glu Ala Lys Lys 
        115                 120                 125             


Ser Phe Asn Asp Asp Ala Met Leu Ile Glu Lys Phe Val Asp Thr Pro 
    130                 135                 140                 


Arg His Val Glu Val Gln Val Phe Gly Asp His His Gly Asn Ala Val 
145                 150                 155                 160 


Tyr Leu Phe Glu Arg Asp Cys Ser Val Gln Arg Arg His Gln Lys Ile 
                165                 170                 175     


Ile Glu Glu Ala Pro Ala Pro Gly Ile Lys Ser Glu Val Arg Lys Lys 
            180                 185                 190         


Leu Gly Glu Ala Ala Val Arg Ala Ala Lys Ala Val Asn Tyr Val Gly 
        195                 200                 205             


Ala Gly Thr Val Glu Phe Ile Met Asp Ser Lys His Asn Phe Cys Phe 
    210                 215                 220                 


Met Glu Met Asn Thr Arg Leu Gln Val Glu His Pro Val Thr Glu Met 
225                 230                 235                 240 


Ile Thr Gly Thr Asp Leu Val Glu Trp Gln Leu Arg Ile Ala Ala Gly 
                245                 250                 255     


Glu Lys Ile Pro Leu Ser Gln Glu Glu Ile Thr Leu Gln Gly His Ala 
            260                 265                 270         


Phe Glu Ala Arg Ile Tyr Ala Glu Asp Pro Ser Asn Asn Phe Met Pro 
        275                 280                 285             


Val Ala Gly Pro Leu Val His Leu Ser Thr Pro Arg Ala Asp Pro Ser 
    290                 295                 300                 


Thr Arg Ile Glu Thr Gly Val Arg Gln Gly Asp Glu Val Ser Val His 
305                 310                 315                 320 


Tyr Asp Pro Met Ile Ala Lys Leu Val Val Trp Ala Ala Asp Arg Gln 
                325                 330                 335     


Ala Ala Leu Thr Lys Leu Arg Tyr Ser Leu Arg Gln Tyr Asn Ile Val 
            340                 345                 350         


Gly Leu His Thr Asn Ile Asp Phe Leu Leu Asn Leu Ser Gly His Pro 
        355                 360                 365             


Glu Phe Glu Ala Gly Asn Val His Thr Asp Phe Ile Pro Gln His His 
    370                 375                 380                 


Lys Gln Leu Leu Leu Ser Arg Lys Ala Ala Ala Lys Glu Ser Leu Cys 
385                 390                 395                 400 


Gln Ala Ala Leu Gly Leu Ile Leu Lys Glu Lys Ala Met Thr Asp Thr 
                405                 410                 415     


Phe Thr Leu Gln Ala His Asp Gln Phe Ser Pro Phe Ser Ser Ser Ser 
            420                 425                 430         


Gly Arg Arg Leu Asn Ile Ser Tyr Thr Arg Asn Met Thr Leu Lys Asp 
        435                 440                 445             


Gly Lys Asn Asn Val Ala Ile Ala Val Thr Tyr Asn His Asp Gly Ser 
    450                 455                 460                 


Tyr Ser Met Gln Ile Glu Asp Lys Thr Phe Gln Val Leu Gly Asn Leu 
465                 470                 475                 480 


Tyr Ser Glu Gly Asp Cys Thr Tyr Leu Lys Cys Ser Val Asn Gly Val 
                485                 490                 495     


Ala Ser Lys Ala Lys Leu Ile Ile Leu Glu Asn Thr Ile Tyr Leu Phe 
            500                 505                 510         


Ser Lys Glu Gly Ser Ile Glu Ile Asp Ile Pro Val Pro Lys Tyr Leu 
        515                 520                 525             


Ser Ser Val Ser Ser Gln Glu Thr Gln Gly Gly Pro Leu Ala Pro Met 
    530                 535                 540                 


Thr Gly Thr Ile Glu Lys Val Phe Val Lys Ala Gly Asp Lys Val Lys 
545                 550                 555                 560 


Ala Gly Asp Ser Leu Met Val Met Ile Ala Met Lys Met Glu His Thr 
                565                 570                 575     


Ile Lys Ser Pro Lys Asp Gly Thr Val Lys Lys Val Phe Tyr Arg Glu 
            580                 585                 590         


Gly Ala Gln Ala Asn Arg His Thr Pro Leu Val Glu Phe Glu Glu Glu 
        595                 600                 605             


Glu Ser Asp Lys Arg Glu Ser Glu 
    610                 615     


<210>  8435
<211>  575
<212>  PRT
<213>  Homo Sapiens

<400>  8435

Met Glu Lys Ile Ile Gln Val Ala Lys Thr Ser Ala Ala Gln His Ile 
1               5                   10                  15      


Gln Ser Ile Met Ala Ala Ala Gly Val Pro Val Val Glu Gly Tyr His 
            20                  25                  30          


Gly Glu Asp Gln Ser Asp Gln Cys Leu Lys Glu His Ala Arg Arg Ile 
        35                  40                  45              


Gly Tyr Pro Val Met Ile Lys Ala Val Arg Gly Gly Gly Gly Lys Gly 
    50                  55                  60                  


Met Arg Ile Val Arg Ser Glu Gln Glu Phe Gln Glu Gln Leu Glu Ser 
65                  70                  75                  80  


Ala Arg Arg Glu Ala Lys Lys Ser Phe Asn Asp Asp Ala Met Leu Ile 
                85                  90                  95      


Glu Lys Phe Val Asp Thr Pro Arg His Val Glu Val Gln Val Phe Gly 
            100                 105                 110         


Asp His His Gly Asn Ala Val Tyr Leu Phe Glu Arg Asp Cys Ser Val 
        115                 120                 125             


Gln Arg Arg His Gln Lys Ile Ile Glu Glu Ala Pro Ala Pro Gly Ile 
    130                 135                 140                 


Lys Ser Glu Val Arg Lys Lys Leu Gly Glu Ala Ala Val Arg Ala Ala 
145                 150                 155                 160 


Lys Ala Val Asn Tyr Val Gly Ala Gly Thr Val Glu Phe Ile Met Asp 
                165                 170                 175     


Ser Lys His Asn Phe Cys Phe Met Glu Met Asn Thr Arg Leu Gln Val 
            180                 185                 190         


Glu His Pro Val Thr Glu Met Ile Thr Gly Thr Asp Leu Val Glu Trp 
        195                 200                 205             


Gln Leu Arg Ile Ala Ala Gly Glu Lys Ile Pro Leu Ser Gln Glu Glu 
    210                 215                 220                 


Ile Thr Leu Gln Gly His Ala Phe Glu Ala Arg Ile Tyr Ala Glu Asp 
225                 230                 235                 240 


Pro Ser Asn Asn Phe Met Pro Val Ala Gly Pro Leu Val His Leu Ser 
                245                 250                 255     


Thr Pro Arg Ala Asp Pro Ser Thr Arg Ile Glu Thr Gly Val Arg Gln 
            260                 265                 270         


Gly Asp Glu Val Ser Val His Tyr Asp Pro Met Ile Ala Lys Leu Val 
        275                 280                 285             


Val Trp Ala Ala Asp Arg Gln Ala Ala Leu Thr Lys Leu Arg Tyr Ser 
    290                 295                 300                 


Leu Arg Gln Tyr Asn Ile Val Gly Leu His Thr Asn Ile Asp Phe Leu 
305                 310                 315                 320 


Leu Asn Leu Ser Gly His Pro Glu Phe Glu Ala Gly Asn Val His Thr 
                325                 330                 335     


Asp Phe Ile Pro Gln His His Lys Gln Leu Leu Leu Ser Arg Lys Ala 
            340                 345                 350         


Ala Ala Lys Glu Ser Leu Cys Gln Ala Ala Leu Gly Leu Ile Leu Lys 
        355                 360                 365             


Glu Lys Ala Met Thr Asp Thr Phe Thr Leu Gln Ala His Asp Gln Phe 
    370                 375                 380                 


Ser Pro Phe Ser Ser Ser Ser Gly Arg Arg Leu Asn Ile Ser Tyr Thr 
385                 390                 395                 400 


Arg Asn Met Thr Leu Lys Asp Gly Lys Asn Asn Val Ala Ile Ala Val 
                405                 410                 415     


Thr Tyr Asn His Asp Gly Ser Tyr Ser Met Gln Ile Glu Asp Lys Thr 
            420                 425                 430         


Phe Gln Val Leu Gly Asn Leu Tyr Ser Glu Gly Asp Cys Thr Tyr Leu 
        435                 440                 445             


Lys Cys Ser Val Asn Gly Val Ala Ser Lys Ala Lys Leu Ile Ile Leu 
    450                 455                 460                 


Glu Asn Thr Ile Tyr Leu Phe Ser Lys Glu Gly Ser Ile Glu Ile Asp 
465                 470                 475                 480 


Ile Pro Val Pro Lys Tyr Leu Ser Ser Val Ser Ser Gln Glu Thr Gln 
                485                 490                 495     


Gly Gly Pro Leu Ala Pro Met Thr Gly Thr Ile Glu Lys Val Phe Val 
            500                 505                 510         


Lys Ala Gly Asp Lys Val Lys Ala Gly Asp Ser Leu Met Val Met Ile 
        515                 520                 525             


Ala Met Lys Met Glu His Thr Ile Lys Ser Pro Lys Asp Gly Thr Val 
    530                 535                 540                 


Lys Lys Val Phe Tyr Arg Glu Gly Ala Gln Ala Asn Arg His Thr Pro 
545                 550                 555                 560 


Leu Val Glu Phe Glu Glu Glu Glu Ser Asp Lys Arg Glu Ser Glu 
                565                 570                 575 


<210>  8436
<211>  434
<212>  PRT
<213>  Homo Sapiens

<400>  8436

Met Lys Tyr Thr Thr Ala Thr Gly Arg Asn Ile Thr Lys Val Leu Ile 
1               5                   10                  15      


Ala Asn Arg Gly Glu Ile Ala Cys Arg Val Met Arg Thr Ala Lys Lys 
            20                  25                  30          


Leu Gly Val Gln Thr Val Ala Val Tyr Ser Glu Ala Asp Arg Asn Ser 
        35                  40                  45              


Met His Val Asp Met Ala Asp Glu Ala Tyr Ser Ile Gly Pro Ala Pro 
    50                  55                  60                  


Ser Gln Gln Ser Tyr Leu Ser Met Glu Lys Ile Ile Gln Val Ala Lys 
65                  70                  75                  80  


Thr Ser Ala Ala Gln Ala Ile His Pro Gly Cys Gly Phe Leu Ser Glu 
                85                  90                  95      


Asn Met Glu Phe Ala Glu Leu Cys Lys Gln Glu Gly Ile Ile Phe Ile 
            100                 105                 110         


Gly Pro Pro Pro Ser Ala Ile Arg Asp Met Gly Ile Lys Ser Thr Ser 
        115                 120                 125             


Lys Ser Ile Met Ala Ala Ala Gly Val Pro Val Val Glu Gly Tyr His 
    130                 135                 140                 


Gly Glu Asp Gln Ser Asp Gln Cys Leu Lys Glu His Ala Arg Arg Ile 
145                 150                 155                 160 


Gly Tyr Pro Val Met Ile Lys Ala Val Arg Gly Gly Gly Gly Lys Gly 
                165                 170                 175     


Met Arg Ile Val Arg Ser Glu Gln Glu Phe Gln Glu Gln Leu Glu Ser 
            180                 185                 190         


Ala Arg Arg Glu Ala Lys Lys Ser Phe Asn Asp Asp Ala Met Leu Ile 
        195                 200                 205             


Glu Lys Phe Val Asp Thr Pro Arg His Val Glu Val Gln Val Phe Gly 
    210                 215                 220                 


Asp His His Gly Asn Ala Val Tyr Leu Phe Glu Arg Asp Cys Ser Val 
225                 230                 235                 240 


Gln Arg Arg His Gln Lys Ile Ile Glu Glu Ala Pro Ala Pro Gly Ile 
                245                 250                 255     


Lys Ser Glu Val Arg Lys Lys Leu Gly Glu Ala Ala Val Arg Ala Ala 
            260                 265                 270         


Lys Ala Val Asn Tyr Val Gly Ala Gly Thr Val Glu Phe Ile Met Asp 
        275                 280                 285             


Ser Lys His Asn Phe Cys Phe Met Glu Met Asn Thr Arg Leu Gln Val 
    290                 295                 300                 


Glu His Pro Val Thr Glu Met Ile Thr Gly Thr Asp Leu Val Glu Trp 
305                 310                 315                 320 


Gln Leu Arg Ile Ala Ala Gly Glu Lys Ile Pro Leu Ser Gln Glu Glu 
                325                 330                 335     


Ile Thr Leu Gln Gly His Ala Phe Glu Ala Arg Ile Tyr Ala Glu Asp 
            340                 345                 350         


Pro Ser Asn Asn Phe Met Pro Val Ala Gly Pro Leu Val His Leu Ser 
        355                 360                 365             


Thr Pro Arg Ala Asp Pro Ser Thr Arg Ile Glu Thr Gly Val Arg Gln 
    370                 375                 380                 


Gly Asp Glu Val Ser Val His Tyr Asp Pro Met Ile Ala Lys Leu Val 
385                 390                 395                 400 


Val Trp Ala Ala Asp Arg Gln Ala Ala Leu Thr Lys Leu Arg Tyr Ser 
                405                 410                 415     


Leu Arg Gln Tyr Asn Ile Asn Ser Leu His Phe Arg Leu Ala Val Glu 
            420                 425                 430         


Glu Asp 
        


<210>  8437
<211>  434
<212>  PRT
<213>  Homo Sapiens

<400>  8437

Met Lys Tyr Thr Thr Ala Thr Gly Arg Asn Ile Thr Lys Val Leu Ile 
1               5                   10                  15      


Ala Asn Arg Gly Glu Ile Ala Cys Arg Val Met Arg Thr Ala Lys Lys 
            20                  25                  30          


Leu Gly Val Gln Thr Val Ala Val Tyr Ser Glu Ala Asp Arg Asn Ser 
        35                  40                  45              


Met His Val Asp Met Ala Asp Glu Ala Tyr Ser Ile Gly Pro Ala Pro 
    50                  55                  60                  


Ser Gln Gln Ser Tyr Leu Ser Met Glu Lys Ile Ile Gln Val Ala Lys 
65                  70                  75                  80  


Thr Ser Ala Ala Gln Ala Ile His Pro Gly Cys Gly Phe Leu Ser Glu 
                85                  90                  95      


Asn Met Glu Phe Ala Glu Leu Cys Lys Gln Glu Gly Ile Ile Phe Ile 
            100                 105                 110         


Gly Pro Pro Pro Ser Ala Ile Arg Asp Met Gly Ile Lys Ser Thr Ser 
        115                 120                 125             


Lys Ser Ile Met Ala Ala Ala Gly Val Pro Val Val Glu Gly Tyr His 
    130                 135                 140                 


Gly Glu Asp Gln Ser Asp Gln Cys Leu Lys Glu His Ala Arg Arg Ile 
145                 150                 155                 160 


Gly Tyr Pro Val Met Ile Lys Ala Val Arg Gly Gly Gly Gly Lys Gly 
                165                 170                 175     


Met Arg Ile Val Arg Ser Glu Gln Glu Phe Gln Glu Gln Leu Glu Ser 
            180                 185                 190         


Ala Arg Arg Glu Ala Lys Lys Ser Phe Asn Asp Asp Ala Met Leu Ile 
        195                 200                 205             


Glu Lys Phe Val Asp Thr Pro Arg His Val Glu Val Gln Val Phe Gly 
    210                 215                 220                 


Asp His His Gly Asn Ala Val Tyr Leu Phe Glu Arg Asp Cys Ser Val 
225                 230                 235                 240 


Gln Arg Arg His Gln Lys Ile Ile Glu Glu Ala Pro Ala Pro Gly Ile 
                245                 250                 255     


Lys Ser Glu Val Arg Lys Lys Leu Gly Glu Ala Ala Val Arg Ala Ala 
            260                 265                 270         


Lys Ala Val Asn Tyr Val Gly Ala Gly Thr Val Glu Phe Ile Met Asp 
        275                 280                 285             


Ser Lys His Asn Phe Cys Phe Met Glu Met Asn Thr Arg Leu Gln Val 
    290                 295                 300                 


Glu His Pro Val Thr Glu Met Ile Thr Gly Thr Asp Leu Val Glu Trp 
305                 310                 315                 320 


Gln Leu Arg Ile Ala Ala Gly Glu Lys Ile Pro Leu Ser Gln Glu Glu 
                325                 330                 335     


Ile Thr Leu Gln Gly His Ala Phe Glu Ala Arg Ile Tyr Ala Glu Asp 
            340                 345                 350         


Pro Ser Asn Asn Phe Met Pro Val Ala Gly Pro Leu Val His Leu Ser 
        355                 360                 365             


Thr Pro Arg Ala Asp Pro Ser Thr Arg Ile Glu Thr Gly Val Arg Gln 
    370                 375                 380                 


Gly Asp Glu Val Ser Val His Tyr Asp Pro Met Ile Ala Lys Leu Val 
385                 390                 395                 400 


Val Trp Ala Ala Asp Arg Gln Ala Ala Leu Thr Lys Leu Arg Tyr Ser 
                405                 410                 415     


Leu Arg Gln Tyr Asn Ile Asn Ser Leu His Phe Arg Leu Ala Val Glu 
            420                 425                 430         


Glu Asp 
        


<210>  8438
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  8438

Met Val Leu Pro Leu Pro Trp Leu Ser Arg Tyr His Phe Leu Arg Leu 
1               5                   10                  15      


Leu Leu Pro Ser Trp Ser Leu Ala Pro Gln Gly Ser His Gly Cys Cys 
            20                  25                  30          


Ser Gln Asn Pro Lys Ala Ser Met Glu Glu Gln Thr Ser Ser Arg Gly 
        35                  40                  45              


Asn Gly Lys Met Thr Ser Pro Pro Arg Gly Pro Gly Thr His Arg Thr 
    50                  55                  60                  


Ala Glu Leu Ala Arg Ala Glu Glu Leu Leu Glu Gln Gln Leu Glu Leu 
65                  70                  75                  80  


Tyr Gln Ala Leu Leu Glu Gly Gln Glu Gly Ala Trp Glu Ala Gln Ala 
                85                  90                  95      


Leu Val Leu Lys Ile Gln Lys Leu Lys Glu Gln Met Arg Arg His Gln 
            100                 105                 110         


Glu Ser Leu Gly Gly Gly Ala 
        115                 


<210>  8439
<211>  78
<212>  PRT
<213>  Homo Sapiens

<400>  8439

Leu Gly Arg Leu Asn His Val Ala Ile Ala Val Pro Asp Leu Glu Lys 
1               5                   10                  15      


Ala Ala Ala Phe Tyr Lys Asn Ile Leu Gly Ala Gln Val Asp Asn Ile 
            20                  25                  30          


Asn Ala Ala Val Met Asp Leu Lys Lys Lys Lys Ile Arg Ser Leu Ser 
        35                  40                  45              


Glu Glu Val Lys Ile Gly Ala His Gly Lys Pro Val Ile Phe Leu His 
    50                  55                  60                  


Pro Lys Asp Cys Gly Gly Val Leu Val Glu Leu Glu Gln Ala 
65                  70                  75              


<210>  8440
<211>  176
<212>  PRT
<213>  Homo Sapiens

<400>  8440

Met Ala Arg Val Leu Lys Ala Ala Ala Ala Asn Ala Val Gly Leu Phe 
1               5                   10                  15      


Ser Arg Leu Gln Ala Pro Ile Pro Thr Val Arg Ala Ser Ser Thr Ser 
            20                  25                  30          


Gln Pro Leu Asp Gln Val Thr Gly Ser Val Trp Asn Leu Gly Arg Leu 
        35                  40                  45              


Asn His Val Ala Ile Ala Val Pro Asp Leu Glu Lys Ala Ala Ala Phe 
    50                  55                  60                  


Tyr Lys Asn Ile Leu Gly Ala Gln Val Ser Glu Ala Val Pro Leu Pro 
65                  70                  75                  80  


Glu His Gly Val Ser Val Val Phe Val Asn Leu Gly Asn Thr Lys Met 
                85                  90                  95      


Glu Leu Leu His Pro Leu Gly Arg Asp Ser Pro Ile Ala Gly Phe Leu 
            100                 105                 110         


Gln Lys Asn Lys Ala Gly Gly Met His His Ile Cys Ile Glu Val Asp 
        115                 120                 125             


Asn Ile Asn Ala Ala Val Met Asp Leu Lys Lys Lys Lys Ile Arg Ser 
    130                 135                 140                 


Leu Ser Glu Glu Val Lys Ile Gly Ala His Gly Lys Pro Val Ile Phe 
145                 150                 155                 160 


Leu His Pro Lys Asp Cys Gly Gly Val Leu Val Glu Leu Glu Gln Ala 
                165                 170                 175     


<210>  8441
<211>  31
<212>  PRT
<213>  Homo Sapiens

<400>  8441

Met Glu Leu Leu His Pro Leu Gly Arg Asp Ser Pro Ile Ala Gly Phe 
1               5                   10                  15      


Leu Gln Lys Asn Lys Ala Gly Gly Met His His Ile Cys Ile Glu 
            20                  25                  30      


<210>  8442
<211>  31
<212>  PRT
<213>  Homo Sapiens

<400>  8442

Met Glu Leu Leu His Pro Leu Gly Arg Asp Ser Pro Ile Ala Gly Phe 
1               5                   10                  15      


Leu Gln Lys Asn Lys Ala Gly Gly Met His His Ile Cys Ile Glu 
            20                  25                  30      


<210>  8443
<211>  1067
<212>  PRT
<213>  Homo Sapiens

<400>  8443

Met Ala Glu Lys Gly Ala Ser Arg Gly Thr Leu Arg Arg Leu Trp Ser 
1               5                   10                  15      


Leu Pro Arg Arg Arg Arg Gly Thr Ala Gly Arg Ser Arg Pro Asp Glu 
            20                  25                  30          


Ile Met His Gln Asp Ile Val Pro Leu Cys Ala Ala Asp Ile Gln Asp 
        35                  40                  45              


Gln Leu Lys Lys Arg Phe Ala Tyr Leu Ser Gly Gly Arg Gly Gln Asp 
    50                  55                  60                  


Gly Ser Pro Val Ile Thr Phe Pro Asp Tyr Pro Ala Phe Ser Glu Ile 
65                  70                  75                  80  


Pro Asp Lys Glu Phe Gln Asn Val Met Thr Tyr Leu Thr Ser Ile Pro 
                85                  90                  95      


Ser Leu Gln Asp Ala Gly Ile Gly Phe Ile Leu Val Ile Asp Arg Arg 
            100                 105                 110         


Arg Asp Lys Trp Thr Ser Val Lys Ala Ser Val Leu Arg Ile Ala Ala 
        115                 120                 125             


Ser Phe Pro Ala Asn Leu Gln Leu Val Leu Val Leu Arg Pro Thr Gly 
    130                 135                 140                 


Phe Phe Gln Arg Thr Leu Ser Asp Ile Ala Phe Lys Phe Asn Arg Asp 
145                 150                 155                 160 


Asp Phe Lys Met Lys Val Pro Val Ile Met Leu Ser Ser Val Pro Asp 
                165                 170                 175     


Leu His Gly Tyr Ile Asp Lys Ser Gln Leu Thr Glu Asp Leu Gly Gly 
            180                 185                 190         


Thr Leu Asp Tyr Cys His Ser Arg Trp Leu Cys Gln Arg Thr Ala Ile 
        195                 200                 205             


Glu Ser Phe Ala Leu Met Val Lys Gln Thr Ala Gln Met Leu Gln Ser 
    210                 215                 220                 


Phe Gly Thr Glu Leu Ala Glu Thr Glu Leu Pro Asn Asp Val Gln Ser 
225                 230                 235                 240 


Thr Ser Ser Val Leu Cys Ala His Thr Glu Lys Lys Asp Lys Ala Lys 
                245                 250                 255     


Glu Asp Leu Arg Leu Ala Leu Lys Glu Gly His Ser Val Leu Glu Ser 
            260                 265                 270         


Leu Arg Glu Leu Gln Ala Glu Gly Ser Glu Pro Ser Val Asn Gln Asp 
        275                 280                 285             


Gln Leu Asp Asn Gln Ala Thr Val Gln Arg Leu Leu Ala Gln Leu Asn 
    290                 295                 300                 


Glu Thr Glu Ala Ala Phe Asp Glu Phe Trp Ala Lys His Gln Gln Lys 
305                 310                 315                 320 


Leu Glu Gln Cys Leu Gln Leu Arg His Phe Glu Gln Gly Phe Arg Glu 
                325                 330                 335     


Val Lys Ala Ile Leu Asp Ala Ala Ser Gln Lys Ile Ala Thr Phe Thr 
            340                 345                 350         


Asp Ile Gly Asn Ser Leu Ala His Val Glu His Leu Leu Arg Asp Leu 
        355                 360                 365             


Ala Ser Phe Glu Glu Lys Ser Gly Val Ala Val Glu Arg Ala Arg Ala 
    370                 375                 380                 


Leu Ser Leu Asp Gly Glu Gln Leu Ile Gly Asn Lys His Tyr Ala Val 
385                 390                 395                 400 


Asp Ser Ile Arg Pro Lys Cys Gln Glu Leu Arg His Leu Cys Asp Gln 
                405                 410                 415     


Phe Ser Ala Glu Ile Ala Arg Arg Arg Gly Leu Leu Ser Lys Ser Leu 
            420                 425                 430         


Glu Leu His Arg Arg Leu Glu Thr Ser Met Lys Trp Cys Asp Glu Gly 
        435                 440                 445             


Ile Tyr Leu Leu Ala Ser Gln Pro Val Asp Lys Cys Gln Ser Gln Asp 
    450                 455                 460                 


Gly Ala Glu Ala Ala Leu Gln Glu Ile Glu Lys Phe Leu Glu Thr Gly 
465                 470                 475                 480 


Ala Glu Asn Lys Ile Gln Glu Leu Asn Ala Ile Tyr Lys Glu Tyr Glu 
                485                 490                 495     


Ser Ile Leu Asn Gln Asp Leu Met Glu His Val Arg Lys Val Phe Gln 
            500                 505                 510         


Lys Gln Ala Ser Met Glu Glu Val Phe His Arg Arg Gln Ala Ser Leu 
        515                 520                 525             


Lys Lys Leu Ala Ala Arg Gln Thr Arg Pro Val Gln Pro Val Ala Pro 
    530                 535                 540                 


Arg Pro Glu Ala Leu Ala Lys Ser Pro Cys Pro Ser Pro Gly Ile Arg 
545                 550                 555                 560 


Arg Gly Ser Glu Asn Ser Ser Ser Glu Gly Gly Ala Leu Arg Arg Gly 
                565                 570                 575     


Pro Tyr Arg Arg Ala Lys Ser Glu Met Ser Glu Ser Arg Gln Gly Arg 
            580                 585                 590         


Gly Ser Ala Gly Glu Glu Glu Glu Ser Leu Ala Ile Leu Arg Arg His 
        595                 600                 605             


Val Met Ser Glu Leu Leu Asp Thr Glu Arg Ala Tyr Val Glu Glu Leu 
    610                 615                 620                 


Leu Cys Val Leu Glu Gly Tyr Ala Ala Glu Met Asp Asn Pro Leu Met 
625                 630                 635                 640 


Ala His Leu Leu Ser Thr Gly Leu His Asn Lys Lys Asp Val Leu Phe 
                645                 650                 655     


Gly Asn Met Glu Glu Ile Tyr His Phe His Asn Arg Ile Phe Leu Arg 
            660                 665                 670         


Glu Leu Glu Asn Tyr Thr Asp Cys Pro Glu Leu Val Gly Arg Cys Phe 
        675                 680                 685             


Leu Glu Arg Met Glu Asp Phe Gln Ile Tyr Glu Lys Tyr Cys Gln Asn 
    690                 695                 700                 


Lys Pro Arg Ser Glu Ser Leu Trp Arg Gln Cys Ser Asp Cys Pro Phe 
705                 710                 715                 720 


Phe Gln Glu Cys Gln Arg Lys Leu Asp His Lys Leu Ser Leu Asp Ser 
                725                 730                 735     


Tyr Leu Leu Lys Pro Val Gln Arg Ile Thr Lys Tyr Gln Leu Leu Leu 
            740                 745                 750         


Lys Glu Met Leu Lys Tyr Ser Arg Asn Cys Glu Gly Ala Glu Asp Leu 
        755                 760                 765             


Gln Glu Ala Leu Ser Ser Ile Leu Gly Ile Leu Lys Ala Val Asn Asp 
    770                 775                 780                 


Ser Met His Leu Ile Ala Ile Thr Gly Tyr Asp Gly Asn Leu Gly Asp 
785                 790                 795                 800 


Leu Gly Lys Leu Leu Met Gln Gly Ser Phe Ser Val Trp Thr Asp His 
                805                 810                 815     


Lys Arg Gly His Thr Lys Val Lys Glu Leu Ala Arg Phe Lys Pro Met 
            820                 825                 830         


Gln Arg His Leu Phe Leu His Glu Lys Ala Val Leu Phe Cys Lys Lys 
        835                 840                 845             


Arg Glu Glu Asn Gly Glu Gly Tyr Glu Lys Ala Pro Ser Tyr Ser Tyr 
    850                 855                 860                 


Lys Gln Ser Leu Asn Met Ala Ala Val Gly Ile Thr Glu Asn Val Lys 
865                 870                 875                 880 


Gly Asp Ala Lys Lys Phe Glu Ile Trp Tyr Asn Ala Arg Glu Glu Val 
                885                 890                 895     


Tyr Ile Val Gln Ala Pro Thr Pro Glu Ile Lys Ala Ala Trp Val Asn 
            900                 905                 910         


Glu Ile Arg Lys Val Leu Thr Ser Gln Leu Gln Ala Cys Arg Glu Ala 
        915                 920                 925             


Ser Gln His Arg Ala Leu Glu Gln Ser Gln Ser Leu Pro Leu Pro Ala 
    930                 935                 940                 


Pro Thr Ser Thr Ser Pro Ser Arg Gly Asn Ser Arg Asn Ile Lys Lys 
945                 950                 955                 960 


Leu Glu Glu Arg Lys Thr Asp Pro Leu Ser Leu Glu Gly Tyr Val Ser 
                965                 970                 975     


Ser Ala Pro Leu Thr Lys Pro Pro Glu Lys Gly Lys Gly Trp Ser Lys 
            980                 985                 990         


Thr Ser His Ser Leu Glu Ala Pro  Glu Asp Asp Gly Gly  Trp Ser Ser 
        995                 1000                 1005             


Ala Glu  Glu Gln Ile Asn Ser  Ser Asp Ala Glu Glu  Asp Gly Gly 
    1010                 1015                 1020             


Leu Gly  Pro Lys Lys Leu Val  Pro Gly Lys Tyr Thr  Val Val Ala 
    1025                 1030                 1035             


Asp His  Glu Lys Gly Gly Pro  Asp Ala Leu Arg Val  Arg Ser Gly 
    1040                 1045                 1050             


Asp Val  Val Glu Leu Val Gln  Glu Gly Asp Glu Gly  Leu Trp 
    1055                 1060                 1065         


<210>  8444
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  8444

Met Phe Asp Cys Trp Arg Phe Ile Leu Cys Lys Arg Pro Gly Ser Asn 
1               5                   10                  15      


Ser Tyr Ser Ser Pro Gln Arg Pro Asn Glu Ala Lys Lys Glu Glu Thr 
            20                  25                  30          


Asp His Gln Ile Asp Val Ser Asp Val Ile Arg Leu Val Gln Asp Thr 
        35                  40                  45              


Pro Glu Ala Thr Ala Met Ala Thr Ala Pro Arg Arg Ser Gln Ser Pro 
    50                  55                  60                  


Gly Leu 
65      


<210>  8445
<211>  1137
<212>  PRT
<213>  Homo Sapiens

<400>  8445

Met Phe Asp Cys Trp Arg Phe Ile Leu Cys Lys Arg Pro Gly Ser Asn 
1               5                   10                  15      


Ser Tyr Ser Ser Pro Gln Arg Pro Asn Glu Ala Lys Lys Glu Glu Thr 
            20                  25                  30          


Asp His Gln Ile Asp Val Ser Asp Val Ile Arg Leu Val Gln Asp Thr 
        35                  40                  45              


Pro Glu Ala Thr Ala Met Ala Thr Asp Glu Ile Met His Gln Asp Ile 
    50                  55                  60                  


Val Pro Leu Cys Ala Ala Asp Ile Gln Asp Gln Leu Lys Lys Arg Phe 
65                  70                  75                  80  


Ala Tyr Leu Ser Gly Gly Arg Gly Gln Asp Gly Ser Pro Val Ile Thr 
                85                  90                  95      


Phe Pro Asp Tyr Pro Ala Phe Ser Glu Ile Pro Asp Lys Glu Phe Gln 
            100                 105                 110         


Asn Val Met Thr Tyr Leu Thr Ser Ile Pro Ser Leu Gln Asp Ala Gly 
        115                 120                 125             


Ile Gly Phe Ile Leu Val Ile Asp Arg Arg Arg Asp Lys Trp Thr Ser 
    130                 135                 140                 


Val Lys Ala Ser Val Leu Arg Ile Ala Ala Ser Phe Pro Ala Asn Leu 
145                 150                 155                 160 


Gln Leu Val Leu Val Leu Arg Pro Thr Gly Phe Phe Gln Arg Thr Leu 
                165                 170                 175     


Ser Asp Ile Ala Phe Lys Phe Asn Arg Asp Asp Phe Lys Met Lys Val 
            180                 185                 190         


Pro Val Ile Met Leu Ser Ser Val Pro Asp Leu His Gly Tyr Ile Asp 
        195                 200                 205             


Lys Ser Gln Leu Thr Glu Asp Leu Gly Gly Thr Leu Asp Tyr Cys His 
    210                 215                 220                 


Ser Arg Trp Leu Cys Gln Arg Thr Ala Ile Glu Ser Phe Ala Leu Met 
225                 230                 235                 240 


Val Lys Gln Thr Ala Gln Met Leu Gln Ser Phe Gly Thr Glu Leu Ala 
                245                 250                 255     


Glu Thr Glu Leu Pro Asn Asp Val Gln Ser Thr Ser Ser Val Leu Cys 
            260                 265                 270         


Ala His Thr Glu Lys Lys Asp Lys Ala Lys Glu Asp Leu Arg Leu Ala 
        275                 280                 285             


Leu Lys Glu Gly His Ser Val Leu Glu Ser Leu Arg Glu Leu Gln Ala 
    290                 295                 300                 


Glu Gly Ser Glu Pro Ser Val Asn Gln Asp Gln Leu Asp Asn Gln Ala 
305                 310                 315                 320 


Thr Val Gln Arg Leu Leu Ala Gln Leu Asn Glu Thr Glu Ala Ala Phe 
                325                 330                 335     


Asp Glu Phe Trp Ala Lys His Gln Gln Lys Leu Glu Gln Cys Leu Gln 
            340                 345                 350         


Leu Arg His Phe Glu Gln Gly Phe Arg Glu Val Lys Ala Ile Leu Asp 
        355                 360                 365             


Ala Ala Ser Gln Lys Ile Ala Thr Phe Thr Asp Ile Gly Asn Ser Leu 
    370                 375                 380                 


Ala His Val Glu His Leu Leu Arg Asp Leu Ala Ser Phe Glu Glu Lys 
385                 390                 395                 400 


Ser Gly Val Ala Val Glu Arg Ala Arg Ala Leu Ser Leu Asp Gly Glu 
                405                 410                 415     


Gln Leu Ile Gly Asn Lys His Tyr Ala Val Asp Ser Ile Arg Pro Lys 
            420                 425                 430         


Cys Gln Glu Leu Arg His Leu Cys Asp Gln Phe Ser Ala Glu Ile Ala 
        435                 440                 445             


Arg Arg Arg Gly Leu Leu Ser Lys Ser Leu Glu Leu His Arg Arg Leu 
    450                 455                 460                 


Glu Thr Ser Met Lys Trp Cys Asp Glu Gly Ile Tyr Leu Leu Ala Ser 
465                 470                 475                 480 


Gln Pro Val Asp Lys Cys Gln Ser Gln Asp Gly Ala Glu Ala Ala Leu 
                485                 490                 495     


Gln Glu Ile Glu Lys Phe Leu Glu Thr Gly Ala Glu Asn Lys Ile Gln 
            500                 505                 510         


Glu Leu Asn Ala Ile Tyr Lys Glu Tyr Glu Ser Ile Leu Asn Gln Asp 
        515                 520                 525             


Leu Met Glu His Val Arg Lys Val Phe Gln Lys Gln Ala Ser Met Glu 
    530                 535                 540                 


Glu Val Phe His Arg Arg Gln Ala Ser Leu Lys Lys Leu Ala Ala Arg 
545                 550                 555                 560 


Gln Thr Arg Pro Val Gln Pro Val Ala Pro Arg Pro Glu Ala Leu Ala 
                565                 570                 575     


Lys Ser Pro Cys Pro Ser Pro Gly Ile Arg Arg Gly Ser Glu Asn Ser 
            580                 585                 590         


Ser Ser Glu Gly Gly Ala Leu Arg Arg Gly Pro Tyr Arg Arg Ala Lys 
        595                 600                 605             


Ser Glu Met Ser Glu Ser Arg Gln Gly Arg Gly Ser Ala Gly Glu Glu 
    610                 615                 620                 


Glu Glu Ser Leu Ala Ile Leu Arg Arg His Val Met Ser Glu Leu Leu 
625                 630                 635                 640 


Asp Thr Glu Arg Ala Tyr Val Glu Glu Leu Leu Cys Val Leu Glu Gly 
                645                 650                 655     


Tyr Ala Ala Glu Met Asp Asn Pro Leu Met Ala His Leu Leu Ser Thr 
            660                 665                 670         


Gly Leu His Asn Lys Lys Asp Val Leu Phe Gly Asn Met Glu Glu Ile 
        675                 680                 685             


Tyr His Phe His Asn Arg Ile Phe Leu Arg Glu Leu Glu Asn Tyr Thr 
    690                 695                 700                 


Asp Cys Pro Glu Leu Val Gly Arg Cys Phe Leu Glu Arg Met Glu Asp 
705                 710                 715                 720 


Phe Gln Ile Tyr Glu Lys Tyr Cys Gln Asn Lys Pro Arg Ser Glu Ser 
                725                 730                 735     


Leu Trp Arg Gln Cys Ser Asp Cys Pro Phe Phe Gln Glu Cys Gln Arg 
            740                 745                 750         


Lys Leu Asp His Lys Leu Ser Leu Asp Ser Tyr Leu Leu Lys Pro Val 
        755                 760                 765             


Gln Arg Ile Thr Lys Tyr Gln Leu Leu Leu Lys Glu Met Leu Lys Tyr 
    770                 775                 780                 


Ser Arg Asn Cys Glu Gly Ala Glu Asp Leu Gln Glu Ala Leu Ser Ser 
785                 790                 795                 800 


Ile Leu Gly Ile Leu Lys Ala Val Asn Asp Ser Met His Leu Ile Ala 
                805                 810                 815     


Ile Thr Gly Tyr Asp Gly Asn Leu Gly Asp Leu Gly Lys Leu Leu Met 
            820                 825                 830         


Gln Gly Ser Phe Ser Val Trp Thr Asp His Lys Arg Gly His Thr Lys 
        835                 840                 845             


Val Lys Glu Leu Ala Arg Phe Lys Pro Met Gln Arg His Leu Phe Leu 
    850                 855                 860                 


His Glu Lys Ala Val Leu Phe Cys Lys Lys Arg Glu Glu Asn Gly Glu 
865                 870                 875                 880 


Gly Tyr Glu Lys Ala Pro Ser Tyr Ser Tyr Lys Gln Ser Leu Asn Met 
                885                 890                 895     


Ala Ala Val Gly Ile Thr Glu Asn Val Lys Gly Asp Ala Lys Lys Phe 
            900                 905                 910         


Glu Ile Trp Tyr Asn Ala Arg Glu Glu Val Tyr Ile Val Gln Ala Pro 
        915                 920                 925             


Thr Pro Glu Ile Lys Ala Ala Trp Val Asn Glu Ile Arg Lys Val Leu 
    930                 935                 940                 


Thr Ser Gln Leu Gln Ala Cys Arg Glu Ala Ser Gln His Arg Ala Leu 
945                 950                 955                 960 


Glu Gln Ser Gln Ser Leu Pro Leu Pro Ala Pro Thr Ser Thr Ser Pro 
                965                 970                 975     


Ser Arg Gly Asn Ser Arg Asn Ile Lys Lys Leu Glu Glu Arg Lys Thr 
            980                 985                 990         


Asp Pro Leu Ser Leu Glu Gly Tyr  Val Ser Ser Ala Pro  Leu Thr Lys 
        995                 1000                 1005             


Pro Pro  Glu Lys Gly Lys Gly  Trp Ser Lys Thr Ser  His Ser Leu 
    1010                 1015                 1020             


Glu Ala  Pro Glu Asp Asp Gly  Gly Trp Ser Ser Ala  Glu Glu Gln 
    1025                 1030                 1035             


Ile Asn  Ser Ser Asp Ala Glu  Glu Asp Gly Gly Leu  Gly Pro Lys 
    1040                 1045                 1050             


Lys Leu  Val Pro Gly Lys Tyr  Thr Val Val Ala Asp  His Glu Lys 
    1055                 1060                 1065             


Gly Gly  Pro Asp Ala Leu Arg  Val Arg Ser Gly Asp  Val Val Glu 
    1070                 1075                 1080             


Leu Val  Gln Glu Gly Asp Glu  Gly Leu Trp Tyr Val  Arg Asp Pro 
    1085                 1090                 1095             


Thr Thr  Gly Lys Glu Gly Trp  Val Pro Ala Ser Ser  Leu Ser Val 
    1100                 1105                 1110             


Arg Leu  Gly Pro Ser Gly Ser  Ala Gln Cys Leu Ser  Ser Ser Gly 
    1115                 1120                 1125             


Lys Ala  His Val Pro Arg Ala  His Pro 
    1130                 1135         


<210>  8446
<211>  64
<212>  PRT
<213>  Homo Sapiens

<400>  8446

Met Phe Asp Cys Trp Arg Phe Ile Leu Cys Lys Arg Pro Gly Ser Asn 
1               5                   10                  15      


Ser Tyr Ser Ser Pro Gln Arg Pro Asn Glu Ala Lys Lys Glu Glu Thr 
            20                  25                  30          


Asp His Gln Ile Asp Val Ser Asp Val Ile Arg Leu Val Gln Asp Thr 
        35                  40                  45              


Pro Glu Ala Thr Ala Met Ala Thr Glu Val Ser Ala Ser Arg Pro Gln 
    50                  55                  60                  


<210>  8447
<211>  97
<212>  PRT
<213>  Homo Sapiens

<400>  8447

Met Gly Asp Gly Lys Ala Val Arg Ile Ser Val Ala Glu Met Lys Ser 
1               5                   10                  15      


Tyr Tyr Leu Tyr Ser Glu Trp Cys Ser Trp Leu Leu Ser Val Ala Glu 
            20                  25                  30          


Asp Glu Ile Met His Gln Asp Ile Val Pro Leu Cys Ala Ala Asp Ile 
        35                  40                  45              


Gln Asp Gln Leu Lys Lys Arg Phe Ala Tyr Leu Ser Gly Gly Arg Gly 
    50                  55                  60                  


Gln Asp Gly Ser Pro Val Ile Thr Phe Pro Asp Tyr Pro Ala Phe Ser 
65                  70                  75                  80  


Glu Ile Pro Asp Lys Glu Phe Gln Asn Val Met Thr Tyr Leu Thr Ser 
                85                  90                  95      


Ile 
    


<210>  8448
<211>  136
<212>  PRT
<213>  Homo Sapiens

<400>  8448

Met His Gln Asp Ile Val Pro Leu Cys Ala Ala Asp Ile Gln Asp Gln 
1               5                   10                  15      


Leu Lys Lys Arg Phe Ala Tyr Leu Ser Gly Gly Arg Gly Gln Asp Gly 
            20                  25                  30          


Ser Pro Val Ile Thr Phe Pro Asp Tyr Pro Ala Phe Ser Glu Ile Pro 
        35                  40                  45              


Asp Lys Glu Phe Gln Asn Val Met Thr Tyr Leu Thr Ser Ile Pro Ser 
    50                  55                  60                  


Leu Gln Asp Ala Gly Ile Gly Phe Ile Leu Val Ile Asp Arg Arg Arg 
65                  70                  75                  80  


Asp Lys Trp Thr Ser Val Lys Ala Ser Val Leu Arg Ile Ala Ala Ser 
                85                  90                  95      


Phe Pro Ala Asn Leu Gln Leu Val Leu Val Leu Arg Pro Thr Gly Phe 
            100                 105                 110         


Phe Gln Arg Thr Leu Ser Asp Ile Ala Phe Lys Phe Asn Arg Asp Asp 
        115                 120                 125             


Phe Lys Met Lys Val Pro Val Ile 
    130                 135     


<210>  8449
<211>  1096
<212>  PRT
<213>  Homo Sapiens

<400>  8449

Met Pro Leu Arg Gly Gly Ala Gly Pro Ser Pro Ala Ser His Gly Pro 
1               5                   10                  15      


Thr His Gly Pro Ser Asp Pro Arg Thr Cys Leu Pro Gly Arg Gly Ala 
            20                  25                  30          


Gly Gly Met Arg Pro His Gly Arg Gly Ala Leu Gly Cys Cys Gly Leu 
        35                  40                  45              


Cys Ser Phe Tyr Thr Cys His Gly Ala Ala Gly Asp Glu Ile Met His 
    50                  55                  60                  


Gln Asp Ile Val Pro Leu Cys Ala Ala Asp Ile Gln Asp Gln Leu Lys 
65                  70                  75                  80  


Lys Arg Phe Ala Tyr Leu Ser Gly Gly Arg Gly Gln Asp Gly Ser Pro 
                85                  90                  95      


Val Ile Thr Phe Pro Asp Tyr Pro Ala Phe Ser Glu Ile Pro Asp Lys 
            100                 105                 110         


Glu Phe Gln Asn Val Met Thr Tyr Leu Thr Ser Ile Pro Ser Leu Gln 
        115                 120                 125             


Asp Ala Gly Ile Gly Phe Ile Leu Val Ile Asp Arg Arg Arg Asp Lys 
    130                 135                 140                 


Trp Thr Ser Val Lys Ala Ser Val Leu Arg Ile Ala Ala Ser Phe Pro 
145                 150                 155                 160 


Ala Asn Leu Gln Leu Val Leu Val Leu Arg Pro Thr Gly Phe Phe Gln 
                165                 170                 175     


Arg Thr Leu Ser Asp Ile Ala Phe Lys Phe Asn Arg Asp Asp Phe Lys 
            180                 185                 190         


Met Lys Val Pro Val Ile Met Leu Ser Ser Val Pro Asp Leu His Gly 
        195                 200                 205             


Tyr Ile Asp Lys Ser Gln Leu Thr Glu Asp Leu Gly Gly Thr Leu Asp 
    210                 215                 220                 


Tyr Cys His Ser Arg Trp Leu Cys Gln Arg Thr Ala Ile Glu Ser Phe 
225                 230                 235                 240 


Ala Leu Met Val Lys Gln Thr Ala Gln Met Leu Gln Ser Phe Gly Thr 
                245                 250                 255     


Glu Leu Ala Glu Thr Glu Leu Pro Asn Asp Val Gln Ser Thr Ser Ser 
            260                 265                 270         


Val Leu Cys Ala His Thr Glu Lys Lys Asp Lys Ala Lys Glu Asp Leu 
        275                 280                 285             


Arg Leu Ala Leu Lys Glu Gly His Ser Val Leu Glu Ser Leu Arg Glu 
    290                 295                 300                 


Leu Gln Ala Glu Gly Ser Glu Pro Ser Val Asn Gln Asp Gln Leu Asp 
305                 310                 315                 320 


Asn Gln Ala Thr Val Gln Arg Leu Leu Ala Gln Leu Asn Glu Thr Glu 
                325                 330                 335     


Ala Ala Phe Asp Glu Phe Trp Ala Lys His Gln Gln Lys Leu Glu Gln 
            340                 345                 350         


Cys Leu Gln Leu Arg His Phe Glu Gln Gly Phe Arg Glu Val Lys Ala 
        355                 360                 365             


Ile Leu Asp Ala Ala Ser Gln Lys Ile Ala Thr Phe Thr Asp Ile Gly 
    370                 375                 380                 


Asn Ser Leu Ala His Val Glu His Leu Leu Arg Asp Leu Ala Ser Phe 
385                 390                 395                 400 


Glu Glu Lys Ser Gly Val Ala Val Glu Arg Ala Arg Ala Leu Ser Leu 
                405                 410                 415     


Asp Gly Glu Gln Leu Ile Gly Asn Lys His Tyr Ala Val Asp Ser Ile 
            420                 425                 430         


Arg Pro Lys Cys Gln Glu Leu Arg His Leu Cys Asp Gln Phe Ser Ala 
        435                 440                 445             


Glu Ile Ala Arg Arg Arg Gly Leu Leu Ser Lys Ser Leu Glu Leu His 
    450                 455                 460                 


Arg Arg Leu Glu Thr Ser Met Lys Trp Cys Asp Glu Gly Ile Tyr Leu 
465                 470                 475                 480 


Leu Ala Ser Gln Pro Val Asp Lys Cys Gln Ser Gln Asp Gly Ala Glu 
                485                 490                 495     


Ala Ala Leu Gln Glu Ile Glu Lys Phe Leu Glu Thr Gly Ala Glu Asn 
            500                 505                 510         


Lys Ile Gln Glu Leu Asn Ala Ile Tyr Lys Glu Tyr Glu Ser Ile Leu 
        515                 520                 525             


Asn Gln Asp Leu Met Glu His Val Arg Lys Val Phe Gln Lys Gln Ala 
    530                 535                 540                 


Ser Met Glu Glu Val Phe His Arg Arg Gln Ala Ser Leu Lys Lys Leu 
545                 550                 555                 560 


Ala Ala Arg Gln Thr Arg Pro Val Gln Pro Val Ala Pro Arg Pro Glu 
                565                 570                 575     


Ala Leu Ala Lys Ser Pro Cys Pro Ser Pro Gly Ile Arg Arg Gly Ser 
            580                 585                 590         


Glu Asn Ser Ser Ser Glu Gly Gly Ala Leu Arg Arg Gly Pro Tyr Arg 
        595                 600                 605             


Arg Ala Lys Ser Glu Met Ser Glu Ser Arg Gln Gly Arg Gly Ser Ala 
    610                 615                 620                 


Gly Glu Glu Glu Glu Ser Leu Ala Ile Leu Arg Arg His Val Met Ser 
625                 630                 635                 640 


Glu Leu Leu Asp Thr Glu Arg Ala Tyr Val Glu Glu Leu Leu Cys Val 
                645                 650                 655     


Leu Glu Gly Tyr Ala Ala Glu Met Asp Asn Pro Leu Met Ala His Leu 
            660                 665                 670         


Leu Ser Thr Gly Leu His Asn Lys Lys Asp Val Leu Phe Gly Asn Met 
        675                 680                 685             


Glu Glu Ile Tyr His Phe His Asn Arg Ile Phe Leu Arg Glu Leu Glu 
    690                 695                 700                 


Asn Tyr Thr Asp Cys Pro Glu Leu Val Gly Arg Cys Phe Leu Glu Arg 
705                 710                 715                 720 


Met Glu Asp Phe Gln Ile Tyr Glu Lys Tyr Cys Gln Asn Lys Pro Arg 
                725                 730                 735     


Ser Glu Ser Leu Trp Arg Gln Cys Ser Asp Cys Pro Phe Phe Gln Glu 
            740                 745                 750         


Cys Gln Arg Lys Leu Asp His Lys Leu Ser Leu Asp Ser Tyr Leu Leu 
        755                 760                 765             


Lys Pro Val Gln Arg Ile Thr Lys Tyr Gln Leu Leu Leu Lys Glu Met 
    770                 775                 780                 


Leu Lys Tyr Ser Arg Asn Cys Glu Gly Ala Glu Asp Leu Gln Glu Ala 
785                 790                 795                 800 


Leu Ser Ser Ile Leu Gly Ile Leu Lys Ala Val Asn Asp Ser Met His 
                805                 810                 815     


Leu Ile Ala Ile Thr Gly Tyr Asp Gly Asn Leu Gly Asp Leu Gly Lys 
            820                 825                 830         


Leu Leu Met Gln Gly Ser Phe Ser Val Trp Thr Asp His Lys Arg Gly 
        835                 840                 845             


His Thr Lys Val Lys Glu Leu Ala Arg Phe Lys Pro Met Gln Arg His 
    850                 855                 860                 


Leu Phe Leu His Glu Lys Ala Val Leu Phe Cys Lys Lys Arg Glu Glu 
865                 870                 875                 880 


Asn Gly Glu Gly Tyr Glu Lys Ala Pro Ser Tyr Ser Tyr Lys Gln Ser 
                885                 890                 895     


Leu Asn Met Ala Ala Val Gly Ile Thr Glu Asn Val Lys Gly Asp Ala 
            900                 905                 910         


Lys Lys Phe Glu Ile Trp Tyr Asn Ala Arg Glu Glu Val Tyr Ile Val 
        915                 920                 925             


Gln Ala Pro Thr Pro Glu Ile Lys Ala Ala Trp Val Asn Glu Ile Arg 
    930                 935                 940                 


Lys Val Leu Thr Ser Gln Leu Gln Ala Cys Arg Glu Ala Ser Gln His 
945                 950                 955                 960 


Arg Ala Leu Glu Gln Ser Gln Ser Leu Pro Leu Pro Ala Pro Thr Ser 
                965                 970                 975     


Thr Ser Pro Ser Arg Gly Asn Ser Arg Asn Ile Lys Lys Leu Glu Glu 
            980                 985                 990         


Arg Lys Thr Asp Pro Leu Ser Leu  Glu Gly Tyr Val Ser  Ser Ala Pro 
        995                 1000                 1005             


Leu Thr  Lys Pro Pro Glu Lys  Gly Lys Gly Trp Ser  Lys Thr Ser 
    1010                 1015                 1020             


His Ser  Leu Glu Ala Pro Glu  Asp Asp Gly Gly Trp  Ser Ser Ala 
    1025                 1030                 1035             


Glu Glu  Gln Ile Asn Ser Ser  Asp Ala Glu Glu Asp  Gly Gly Leu 
    1040                 1045                 1050             


Gly Pro  Lys Lys Leu Val Pro  Gly Lys Tyr Thr Val  Val Ala Asp 
    1055                 1060                 1065             


His Glu  Lys Gly Gly Pro Asp  Ala Leu Arg Val Arg  Ser Gly Asp 
    1070                 1075                 1080             


Val Val  Glu Leu Val Gln Glu  Gly Asp Glu Gly Leu  Trp 
    1085                 1090                 1095     


<210>  8450
<211>  1125
<212>  PRT
<213>  Homo Sapiens

<400>  8450

Met Arg Phe Trp Leu Arg Thr Glu Glu Met Ala Leu Glu Glu Met Val 
1               5                   10                  15      


Gln Arg Leu Asn Ala Val Ser Lys His Thr Asp Glu Ile Met His Gln 
            20                  25                  30          


Asp Ile Val Pro Leu Cys Ala Ala Asp Ile Gln Asp Gln Leu Lys Lys 
        35                  40                  45              


Arg Phe Ala Tyr Leu Ser Gly Gly Arg Gly Gln Asp Gly Ser Pro Val 
    50                  55                  60                  


Ile Thr Phe Pro Asp Tyr Pro Ala Phe Ser Glu Ile Pro Asp Lys Glu 
65                  70                  75                  80  


Phe Gln Asn Val Met Thr Tyr Leu Thr Ser Ile Pro Ser Leu Gln Asp 
                85                  90                  95      


Ala Gly Ile Gly Phe Ile Leu Val Ile Asp Arg Arg Arg Asp Lys Trp 
            100                 105                 110         


Thr Ser Val Lys Ala Ser Val Leu Arg Ile Ala Ala Ser Phe Pro Ala 
        115                 120                 125             


Asn Leu Gln Leu Val Leu Val Leu Arg Pro Thr Gly Phe Phe Gln Arg 
    130                 135                 140                 


Thr Leu Ser Asp Ile Ala Phe Lys Phe Asn Arg Asp Asp Phe Lys Met 
145                 150                 155                 160 


Lys Val Pro Val Ile Met Leu Ser Ser Val Pro Asp Leu His Gly Tyr 
                165                 170                 175     


Ile Asp Lys Ser Gln Leu Thr Glu Asp Leu Gly Gly Thr Leu Asp Tyr 
            180                 185                 190         


Cys His Ser Arg Trp Leu Cys Gln Arg Thr Ala Ile Glu Ser Phe Ala 
        195                 200                 205             


Leu Met Val Lys Gln Thr Ala Gln Met Leu Gln Ser Phe Gly Thr Glu 
    210                 215                 220                 


Leu Ala Glu Thr Glu Leu Pro Asn Asp Val Gln Ser Thr Ser Ser Val 
225                 230                 235                 240 


Leu Cys Ala His Thr Glu Lys Lys Asp Lys Ala Lys Glu Asp Leu Arg 
                245                 250                 255     


Leu Ala Leu Lys Glu Gly His Ser Val Leu Glu Ser Leu Arg Glu Leu 
            260                 265                 270         


Gln Ala Glu Gly Ser Glu Pro Ser Val Asn Gln Asp Gln Leu Asp Asn 
        275                 280                 285             


Gln Ala Thr Val Gln Arg Leu Leu Ala Gln Leu Asn Glu Thr Glu Ala 
    290                 295                 300                 


Ala Phe Asp Glu Phe Trp Ala Lys His Gln Gln Lys Leu Glu Gln Cys 
305                 310                 315                 320 


Leu Gln Leu Arg His Phe Glu Gln Gly Phe Arg Glu Val Lys Ala Ile 
                325                 330                 335     


Leu Asp Ala Ala Ser Gln Lys Ile Ala Thr Phe Thr Asp Ile Gly Asn 
            340                 345                 350         


Ser Leu Ala His Val Glu His Leu Leu Arg Asp Leu Ala Ser Phe Glu 
        355                 360                 365             


Glu Lys Ser Gly Val Ala Val Glu Arg Ala Arg Ala Leu Ser Leu Asp 
    370                 375                 380                 


Gly Glu Gln Leu Ile Gly Asn Lys His Tyr Ala Val Asp Ser Ile Arg 
385                 390                 395                 400 


Pro Lys Cys Gln Glu Leu Arg His Leu Cys Asp Gln Phe Ser Ala Glu 
                405                 410                 415     


Ile Ala Arg Arg Arg Gly Leu Leu Ser Lys Ser Leu Glu Leu His Arg 
            420                 425                 430         


Arg Leu Glu Thr Ser Met Lys Trp Cys Asp Glu Gly Ile Tyr Leu Leu 
        435                 440                 445             


Ala Ser Gln Pro Val Asp Lys Cys Gln Ser Gln Asp Gly Ala Glu Ala 
    450                 455                 460                 


Ala Leu Gln Glu Ile Glu Lys Phe Leu Glu Thr Gly Ala Glu Asn Lys 
465                 470                 475                 480 


Ile Gln Glu Leu Asn Ala Ile Tyr Lys Glu Tyr Glu Ser Ile Leu Asn 
                485                 490                 495     


Gln Asp Leu Met Glu His Val Arg Lys Val Phe Gln Lys Gln Ala Ser 
            500                 505                 510         


Met Glu Glu Val Phe His Arg Arg Gln Ala Ser Leu Lys Lys Leu Ala 
        515                 520                 525             


Ala Arg Gln Thr Arg Pro Val Gln Pro Val Ala Pro Arg Pro Glu Ala 
    530                 535                 540                 


Leu Ala Lys Ser Pro Cys Pro Ser Pro Gly Ile Arg Arg Gly Ser Glu 
545                 550                 555                 560 


Asn Ser Ser Ser Glu Gly Gly Ala Leu Arg Arg Gly Pro Tyr Arg Arg 
                565                 570                 575     


Ala Lys Ser Glu Met Ser Glu Ser Arg Gln Gly Arg Gly Ser Ala Gly 
            580                 585                 590         


Glu Glu Glu Glu Ser Leu Ala Ile Leu Arg Arg His Val Met Ser Glu 
        595                 600                 605             


Leu Leu Asp Thr Glu Arg Ala Tyr Val Glu Glu Leu Leu Cys Val Leu 
    610                 615                 620                 


Glu Gly Tyr Ala Ala Glu Met Asp Asn Pro Leu Met Ala His Leu Leu 
625                 630                 635                 640 


Ser Thr Gly Leu His Asn Lys Lys Asp Val Leu Phe Gly Asn Met Glu 
                645                 650                 655     


Glu Ile Tyr His Phe His Asn Arg Ile Phe Leu Arg Glu Leu Glu Asn 
            660                 665                 670         


Tyr Thr Asp Cys Pro Glu Leu Val Gly Arg Cys Phe Leu Glu Arg Met 
        675                 680                 685             


Glu Asp Phe Gln Ile Tyr Glu Lys Tyr Cys Gln Asn Lys Pro Arg Ser 
    690                 695                 700                 


Glu Ser Leu Trp Arg Gln Cys Ser Asp Cys Pro Phe Phe Gln Glu Cys 
705                 710                 715                 720 


Gln Arg Lys Leu Asp His Lys Leu Ser Leu Asp Ser Tyr Leu Leu Lys 
                725                 730                 735     


Pro Val Gln Arg Ile Thr Lys Tyr Gln Leu Leu Leu Lys Glu Met Leu 
            740                 745                 750         


Lys Tyr Ser Arg Asn Cys Glu Gly Ala Glu Asp Leu Gln Glu Ala Leu 
        755                 760                 765             


Ser Ser Ile Leu Gly Ile Leu Lys Ala Val Asn Asp Ser Met His Leu 
    770                 775                 780                 


Ile Ala Ile Thr Gly Tyr Asp Gly Asn Leu Gly Asp Leu Gly Lys Leu 
785                 790                 795                 800 


Leu Met Gln Gly Ser Phe Ser Val Trp Thr Asp His Lys Arg Gly His 
                805                 810                 815     


Thr Lys Val Lys Glu Leu Ala Arg Phe Lys Pro Met Gln Arg His Leu 
            820                 825                 830         


Phe Leu His Glu Lys Ala Val Leu Phe Cys Lys Lys Arg Glu Glu Asn 
        835                 840                 845             


Gly Glu Gly Tyr Glu Lys Ala Pro Ser Tyr Ser Tyr Lys Gln Ser Leu 
    850                 855                 860                 


Asn Met Ala Ala Val Gly Ile Thr Glu Asn Val Lys Gly Asp Ala Lys 
865                 870                 875                 880 


Lys Phe Glu Ile Trp Tyr Asn Ala Arg Glu Glu Val Tyr Ile Val Gln 
                885                 890                 895     


Ala Pro Thr Pro Glu Ile Lys Ala Ala Trp Val Asn Glu Ile Arg Lys 
            900                 905                 910         


Val Leu Thr Ser Gln Leu Gln Ala Cys Arg Glu Ala Ser Gln His Arg 
        915                 920                 925             


Ala Leu Glu Gln Ser Gln Ser Leu Pro Leu Pro Ala Pro Thr Ser Thr 
    930                 935                 940                 


Ser Pro Ser Arg Gly Asn Ser Arg Asn Ile Lys Lys Leu Glu Glu Arg 
945                 950                 955                 960 


Lys Thr Asp Pro Leu Ser Leu Glu Gly Tyr Val Ser Ser Ala Pro Leu 
                965                 970                 975     


Thr Lys Pro Pro Glu Lys Gly Lys Gly Trp Ser Lys Thr Ser His Ser 
            980                 985                 990         


Leu Glu Ala Pro Glu Asp Asp Gly  Gly Trp Ser Ser Ala  Glu Glu Gln 
        995                 1000                 1005             


Ile Asn  Ser Ser Asp Ala Glu  Glu Asp Gly Gly Leu  Gly Pro Lys 
    1010                 1015                 1020             


Lys Leu  Val Pro Gly Lys Tyr  Thr Val Val Ala Asp  His Glu Lys 
    1025                 1030                 1035             


Gly Gly  Pro Asp Ala Leu Arg  Val Arg Ser Gly Asp  Val Val Glu 
    1040                 1045                 1050             


Leu Val  Gln Glu Gly Asp Glu  Gly Leu Trp Tyr Val  Arg Asp Pro 
    1055                 1060                 1065             


Thr Thr  Gly Lys Glu Gly Trp  Val Pro Ala Ser Ser  Leu Ser Val 
    1070                 1075                 1080             


Arg Leu  Gly Pro Ser Gly Ser  Ala Gln Cys Leu Ser  Ser Ser Glu 
    1085                 1090                 1095             


Ser Ser  Pro Gly Ser Ala Val  Leu Ser Asn Ser Ser  Ser Cys Ser 
    1100                 1105                 1110             


Glu Gly  Gly Gln Ala Pro Phe  Ser Asp Leu Gln Gly  
    1115                 1120                 1125 


<210>  8451
<211>  136
<212>  PRT
<213>  Homo Sapiens

<400>  8451

Met Thr Val Arg Arg Leu Ser Leu Leu Cys Arg Asp Leu Trp Ala Leu 
1               5                   10                  15      


Trp Leu Leu Leu Lys Ala Gly Ala Asp Glu Ile Met His Gln Asp Ile 
            20                  25                  30          


Val Pro Leu Cys Ala Ala Asp Ile Gln Asp Gln Leu Lys Lys Arg Phe 
        35                  40                  45              


Ala Tyr Leu Ser Gly Gly Arg Gly Gln Asp Gly Ser Pro Val Ile Thr 
    50                  55                  60                  


Phe Pro Asp Tyr Pro Ala Phe Ser Glu Ile Pro Asp Lys Glu Phe Gln 
65                  70                  75                  80  


Asn Val Met Thr Tyr Leu Thr Ser Ile Pro Ser Gly Gly Gln Glu Ser 
                85                  90                  95      


Ser Ile Arg Pro Val Ser Cys Arg Leu Thr Trp Glu Gly Cys Arg Gly 
            100                 105                 110         


Gly Leu Ser Ser Asp Val Leu Val Pro Ala Ser Arg Lys Met Leu Arg 
        115                 120                 125             


Met Ser Ala Ser His Gln Thr Val 
    130                 135     


<210>  8452
<211>  1123
<212>  PRT
<213>  Homo Sapiens

<400>  8452

Met Thr Val Arg Arg Leu Ser Leu Leu Cys Arg Asp Leu Trp Ala Leu 
1               5                   10                  15      


Trp Leu Leu Leu Lys Ala Gly Ala Asp Glu Ile Met His Gln Asp Ile 
            20                  25                  30          


Val Pro Leu Cys Ala Ala Asp Ile Gln Asp Gln Leu Lys Lys Arg Phe 
        35                  40                  45              


Ala Tyr Leu Ser Gly Gly Arg Gly Gln Asp Gly Ser Pro Val Ile Thr 
    50                  55                  60                  


Phe Pro Asp Tyr Pro Ala Phe Ser Glu Ile Pro Asp Lys Glu Phe Gln 
65                  70                  75                  80  


Asn Val Met Thr Tyr Leu Thr Ser Ile Pro Ser Leu Gln Asp Ala Gly 
                85                  90                  95      


Ile Gly Phe Ile Leu Val Ile Asp Arg Arg Arg Asp Lys Trp Thr Ser 
            100                 105                 110         


Val Lys Ala Ser Val Leu Arg Ile Ala Ala Ser Phe Pro Ala Asn Leu 
        115                 120                 125             


Gln Leu Val Leu Val Leu Arg Pro Thr Gly Phe Phe Gln Arg Thr Leu 
    130                 135                 140                 


Ser Asp Ile Ala Phe Lys Phe Asn Arg Asp Asp Phe Lys Met Lys Val 
145                 150                 155                 160 


Pro Val Ile Met Leu Ser Ser Val Pro Asp Leu His Gly Tyr Ile Asp 
                165                 170                 175     


Lys Ser Gln Leu Thr Glu Asp Leu Gly Gly Thr Leu Asp Tyr Cys His 
            180                 185                 190         


Ser Arg Trp Leu Cys Gln Arg Thr Ala Ile Glu Ser Phe Ala Leu Met 
        195                 200                 205             


Val Lys Gln Thr Ala Gln Met Leu Gln Ser Phe Gly Thr Glu Leu Ala 
    210                 215                 220                 


Glu Thr Glu Leu Pro Asn Asp Val Gln Ser Thr Ser Ser Val Leu Cys 
225                 230                 235                 240 


Ala His Thr Glu Lys Lys Asp Lys Ala Lys Glu Asp Leu Arg Leu Ala 
                245                 250                 255     


Leu Lys Glu Gly His Ser Val Leu Glu Ser Leu Arg Glu Leu Gln Ala 
            260                 265                 270         


Glu Gly Ser Glu Pro Ser Val Asn Gln Asp Gln Leu Asp Asn Gln Ala 
        275                 280                 285             


Thr Val Gln Arg Leu Leu Ala Gln Leu Asn Glu Thr Glu Ala Ala Phe 
    290                 295                 300                 


Asp Glu Phe Trp Ala Lys His Gln Gln Lys Leu Glu Gln Cys Leu Gln 
305                 310                 315                 320 


Leu Arg His Phe Glu Gln Gly Phe Arg Glu Val Lys Ala Ile Leu Asp 
                325                 330                 335     


Ala Ala Ser Gln Lys Ile Ala Thr Phe Thr Asp Ile Gly Asn Ser Leu 
            340                 345                 350         


Ala His Val Glu His Leu Leu Arg Asp Leu Ala Ser Phe Glu Glu Lys 
        355                 360                 365             


Ser Gly Val Ala Val Glu Arg Ala Arg Ala Leu Ser Leu Asp Gly Glu 
    370                 375                 380                 


Gln Leu Ile Gly Asn Lys His Tyr Ala Val Asp Ser Ile Arg Pro Lys 
385                 390                 395                 400 


Cys Gln Glu Leu Arg His Leu Cys Asp Gln Phe Ser Ala Glu Ile Ala 
                405                 410                 415     


Arg Arg Arg Gly Leu Leu Ser Lys Ser Leu Glu Leu His Arg Arg Leu 
            420                 425                 430         


Glu Thr Ser Met Lys Trp Cys Asp Glu Gly Ile Tyr Leu Leu Ala Ser 
        435                 440                 445             


Gln Pro Val Asp Lys Cys Gln Ser Gln Asp Gly Ala Glu Ala Ala Leu 
    450                 455                 460                 


Gln Glu Ile Glu Lys Phe Leu Glu Thr Gly Ala Glu Asn Lys Ile Gln 
465                 470                 475                 480 


Glu Leu Asn Ala Ile Tyr Lys Glu Tyr Glu Ser Ile Leu Asn Gln Asp 
                485                 490                 495     


Leu Met Glu His Val Arg Lys Val Phe Gln Lys Gln Ala Ser Met Glu 
            500                 505                 510         


Glu Val Phe His Arg Arg Gln Ala Ser Leu Lys Lys Leu Ala Ala Arg 
        515                 520                 525             


Gln Thr Arg Pro Val Gln Pro Val Ala Pro Arg Pro Glu Ala Leu Ala 
    530                 535                 540                 


Lys Ser Pro Cys Pro Ser Pro Gly Ile Arg Arg Gly Ser Glu Asn Ser 
545                 550                 555                 560 


Ser Ser Glu Gly Gly Ala Leu Arg Arg Gly Pro Tyr Arg Arg Ala Lys 
                565                 570                 575     


Ser Glu Met Ser Glu Ser Arg Gln Gly Arg Gly Ser Ala Gly Glu Glu 
            580                 585                 590         


Glu Glu Ser Leu Ala Ile Leu Arg Arg His Val Met Ser Glu Leu Leu 
        595                 600                 605             


Asp Thr Glu Arg Ala Tyr Val Glu Glu Leu Leu Cys Val Leu Glu Gly 
    610                 615                 620                 


Tyr Ala Ala Glu Met Asp Asn Pro Leu Met Ala His Leu Leu Ser Thr 
625                 630                 635                 640 


Gly Leu His Asn Lys Lys Asp Val Leu Phe Gly Asn Met Glu Glu Ile 
                645                 650                 655     


Tyr His Phe His Asn Arg Ile Phe Leu Arg Glu Leu Glu Asn Tyr Thr 
            660                 665                 670         


Asp Cys Pro Glu Leu Val Gly Arg Cys Phe Leu Glu Arg Met Glu Asp 
        675                 680                 685             


Phe Gln Ile Tyr Glu Lys Tyr Cys Gln Asn Lys Pro Arg Ser Glu Ser 
    690                 695                 700                 


Leu Trp Arg Gln Cys Ser Asp Cys Pro Phe Phe Gln Glu Cys Gln Arg 
705                 710                 715                 720 


Lys Leu Asp His Lys Leu Ser Leu Asp Ser Tyr Leu Leu Lys Pro Val 
                725                 730                 735     


Gln Arg Ile Thr Lys Tyr Gln Leu Leu Leu Lys Glu Met Leu Lys Tyr 
            740                 745                 750         


Ser Arg Asn Cys Glu Gly Ala Glu Asp Leu Gln Glu Ala Leu Ser Ser 
        755                 760                 765             


Ile Leu Gly Ile Leu Lys Ala Val Asn Asp Ser Met His Leu Ile Ala 
    770                 775                 780                 


Ile Thr Gly Tyr Asp Gly Asn Leu Gly Asp Leu Gly Lys Leu Leu Met 
785                 790                 795                 800 


Gln Gly Ser Phe Ser Val Trp Thr Asp His Lys Arg Gly His Thr Lys 
                805                 810                 815     


Val Lys Glu Leu Ala Arg Phe Lys Pro Met Gln Arg His Leu Phe Leu 
            820                 825                 830         


His Glu Lys Ala Val Leu Phe Cys Lys Lys Arg Glu Glu Asn Gly Glu 
        835                 840                 845             


Gly Tyr Glu Lys Ala Pro Ser Tyr Ser Tyr Lys Gln Ser Leu Asn Met 
    850                 855                 860                 


Ala Ala Val Gly Ile Thr Glu Asn Val Lys Gly Asp Ala Lys Lys Phe 
865                 870                 875                 880 


Glu Ile Trp Tyr Asn Ala Arg Glu Glu Val Tyr Ile Val Gln Ala Pro 
                885                 890                 895     


Thr Pro Glu Ile Lys Ala Ala Trp Val Asn Glu Ile Arg Lys Val Leu 
            900                 905                 910         


Thr Ser Gln Leu Gln Ala Cys Arg Glu Ala Ser Gln His Arg Ala Leu 
        915                 920                 925             


Glu Gln Ser Gln Ser Leu Pro Leu Pro Ala Pro Thr Ser Thr Ser Pro 
    930                 935                 940                 


Ser Arg Gly Asn Ser Arg Asn Ile Lys Lys Leu Glu Glu Arg Lys Thr 
945                 950                 955                 960 


Asp Pro Leu Ser Leu Glu Gly Tyr Val Ser Ser Ala Pro Leu Thr Lys 
                965                 970                 975     


Pro Pro Glu Lys Gly Lys Gly Trp Ser Lys Thr Ser His Ser Leu Glu 
            980                 985                 990         


Ala Pro Glu Asp Asp Gly Gly Trp  Ser Ser Ala Glu Glu  Gln Ile Asn 
        995                 1000                 1005             


Ser Ser  Asp Ala Glu Glu Asp  Gly Gly Leu Gly Pro  Lys Lys Leu 
    1010                 1015                 1020             


Val Pro  Gly Lys Tyr Thr Val  Val Ala Asp His Glu  Lys Gly Gly 
    1025                 1030                 1035             


Pro Asp  Ala Leu Arg Val Arg  Ser Gly Asp Val Val  Glu Leu Val 
    1040                 1045                 1050             


Gln Glu  Gly Asp Glu Gly Leu  Trp Tyr Val Arg Asp  Pro Thr Thr 
    1055                 1060                 1065             


Gly Lys  Glu Gly Trp Val Pro  Ala Ser Ser Leu Ser  Val Arg Leu 
    1070                 1075                 1080             


Gly Pro  Ser Gly Ser Ala Gln  Cys Leu Ser Ser Ser  Glu Ser Ser 
    1085                 1090                 1095             


Pro Gly  Ser Ala Val Leu Ser  Asn Ser Ser Ser Cys  Ser Glu Gly 
    1100                 1105                 1110             


Gly Gln  Ala Pro Phe Ser Asp  Leu Gln Gly 
    1115                 1120             


<210>  8453
<211>  984
<212>  PRT
<213>  Homo Sapiens

<400>  8453

Met Thr Val Arg Arg Leu Ser Leu Leu Cys Arg Asp Leu Trp Ala Leu 
1               5                   10                  15      


Trp Leu Leu Leu Lys Ala Gly Ala Asp Glu Ile Met His Gln Asp Ile 
            20                  25                  30          


Val Pro Leu Cys Ala Ala Asp Ile Gln Asp Gln Leu Lys Lys Arg Phe 
        35                  40                  45              


Ala Tyr Leu Ser Gly Gly Arg Gly Gln Asp Gly Ser Pro Val Ile Thr 
    50                  55                  60                  


Phe Pro Asp Tyr Pro Ala Phe Ser Glu Ile Pro Asp Lys Glu Phe Gln 
65                  70                  75                  80  


Asn Val Met Thr Tyr Leu Thr Ser Ile Pro Ser Leu Gln Asp Ala Gly 
                85                  90                  95      


Ile Gly Phe Ile Leu Val Ile Asp Arg Arg Arg Asp Lys Trp Thr Ser 
            100                 105                 110         


Val Lys Ala Ser Val Leu Arg Ile Ala Ala Ser Phe Pro Ala Asn Leu 
        115                 120                 125             


Gln Leu Val Leu Val Leu Arg Pro Thr Gly Phe Phe Gln Arg Thr Leu 
    130                 135                 140                 


Ser Asp Ile Ala Phe Lys Phe Asn Arg Asp Asp Phe Lys Met Lys Val 
145                 150                 155                 160 


Pro Val Ile Met Leu Ser Ser Val Pro Asp Leu His Gly Tyr Ile Asp 
                165                 170                 175     


Lys Ser Gln Leu Thr Glu Asp Leu Gly Gly Thr Leu Asp Tyr Cys His 
            180                 185                 190         


Ser Arg Trp Leu Cys Gln Arg Thr Ala Ile Glu Ser Phe Ala Leu Met 
        195                 200                 205             


Val Lys Gln Thr Ala Gln Met Leu Gln Ser Phe Gly Thr Glu Leu Ala 
    210                 215                 220                 


Glu Thr Glu Leu Pro Asn Asp Val Gln Ser Thr Ser Ser Val Leu Cys 
225                 230                 235                 240 


Ala His Thr Glu Lys Lys Asp Lys Ala Lys Glu Asp Leu Arg Leu Ala 
                245                 250                 255     


Leu Lys Glu Gly His Ser Val Leu Glu Ser Leu Arg Glu Leu Gln Ala 
            260                 265                 270         


Glu Gly Ser Glu Pro Ser Val Asn Gln Asp Gln Leu Asp Asn Gln Ala 
        275                 280                 285             


Thr Val Gln Arg Leu Leu Ala Gln Leu Asn Glu Thr Glu Ala Ala Phe 
    290                 295                 300                 


Asp Glu Phe Trp Ala Lys His Gln Gln Lys Leu Glu Gln Cys Leu Gln 
305                 310                 315                 320 


Leu Arg His Phe Glu Gln Gly Phe Arg Glu Val Lys Ala Ile Leu Asp 
                325                 330                 335     


Ala Ala Ser Gln Lys Ile Ala Thr Phe Thr Asp Ile Gly Asn Ser Leu 
            340                 345                 350         


Ala His Val Glu His Leu Leu Arg Asp Leu Ala Ser Phe Glu Glu Lys 
        355                 360                 365             


Ser Gly Val Ala Val Glu Arg Ala Arg Ala Leu Ser Leu Asp Gly Glu 
    370                 375                 380                 


Gln Leu Ile Gly Asn Lys His Tyr Ala Val Asp Ser Ile Arg Pro Lys 
385                 390                 395                 400 


Cys Gln Glu Leu Arg His Leu Cys Asp Gln Phe Ser Ala Glu Ile Ala 
                405                 410                 415     


Arg Arg Arg Gly Leu Leu Ser Lys Ser Leu Glu Leu His Arg Arg Leu 
            420                 425                 430         


Glu Thr Ser Met Lys Trp Cys Asp Glu Gly Ile Tyr Leu Leu Ala Ser 
        435                 440                 445             


Gln Pro Val Asp Lys Cys Gln Ser Gln Asp Gly Ala Glu Ala Ala Leu 
    450                 455                 460                 


Gln Glu Ile Glu Lys Phe Leu Glu Thr Gly Ala Glu Asn Lys Ile Gln 
465                 470                 475                 480 


Glu Leu Asn Ala Ile Tyr Lys Glu Tyr Glu Ser Ile Leu Asn Gln Asp 
                485                 490                 495     


Leu Met Glu His Val Arg Lys Val Phe Gln Lys Gln Ala Ser Met Glu 
            500                 505                 510         


Glu Val Phe His Arg Arg Gln Ala Ser Leu Lys Lys Leu Ala Ala Arg 
        515                 520                 525             


Gln Thr Arg Pro Val Gln Pro Val Ala Pro Arg Pro Glu Ala Leu Ala 
    530                 535                 540                 


Lys Ser Pro Cys Pro Ser Pro Gly Ile Arg Arg Gly Ser Glu Asn Ser 
545                 550                 555                 560 


Ser Ser Glu Gly Gly Ala Leu Arg Arg Gly Pro Tyr Arg Arg Ala Lys 
                565                 570                 575     


Ser Glu Met Ser Glu Ser Arg Gln Gly Arg Gly Ser Ala Gly Glu Glu 
            580                 585                 590         


Glu Glu Ser Leu Ala Ile Leu Arg Arg His Val Met Ser Glu Leu Leu 
        595                 600                 605             


Asp Thr Glu Arg Ala Tyr Val Glu Glu Leu Leu Cys Val Leu Glu Gly 
    610                 615                 620                 


Tyr Ala Ala Glu Met Asp Asn Pro Leu Met Ala His Leu Leu Ser Thr 
625                 630                 635                 640 


Gly Leu His Asn Lys Lys Asp Val Leu Phe Gly Asn Met Glu Glu Ile 
                645                 650                 655     


Tyr His Phe His Asn Arg Ile Phe Leu Arg Glu Leu Glu Asn Tyr Thr 
            660                 665                 670         


Asp Cys Pro Glu Leu Val Gly Arg Cys Phe Leu Glu Arg Met Glu Asp 
        675                 680                 685             


Phe Gln Ile Tyr Glu Lys Tyr Cys Gln Asn Lys Pro Arg Ser Glu Ser 
    690                 695                 700                 


Leu Trp Arg Gln Cys Ser Asp Cys Pro Phe Phe Gln Glu Cys Gln Arg 
705                 710                 715                 720 


Lys Leu Asp His Lys Leu Ser Leu Asp Ser Tyr Leu Leu Lys Pro Val 
                725                 730                 735     


Gln Arg Ile Thr Lys Tyr Gln Leu Leu Leu Lys Glu Met Leu Lys Tyr 
            740                 745                 750         


Ser Arg Asn Cys Glu Gly Ala Glu Asp Leu Gln Glu Ala Leu Ser Ser 
        755                 760                 765             


Ile Leu Gly Ile Leu Lys Ala Val Asn Asp Ser Met His Leu Ile Ala 
    770                 775                 780                 


Ile Thr Gly Tyr Asp Gly Asn Leu Gly Asp Leu Gly Lys Leu Leu Met 
785                 790                 795                 800 


Gln Gly Ser Phe Ser Val Trp Thr Asp His Lys Arg Gly His Thr Lys 
                805                 810                 815     


Val Lys Glu Leu Ala Arg Phe Lys Pro Met Gln Arg His Leu Phe Leu 
            820                 825                 830         


His Glu Lys Ala Val Leu Phe Cys Lys Lys Arg Glu Glu Asn Gly Glu 
        835                 840                 845             


Gly Tyr Glu Lys Ala Pro Ser Tyr Ser Tyr Lys Gln Ser Leu Asn Met 
    850                 855                 860                 


Ala Ala Val Gly Ile Thr Glu Asn Val Lys Gly Asp Ala Lys Lys Phe 
865                 870                 875                 880 


Glu Ile Trp Tyr Asn Ala Arg Glu Glu Val Tyr Ile Val Gln Ala Pro 
                885                 890                 895     


Thr Pro Glu Ile Lys Ala Ala Trp Val Asn Glu Ile Arg Lys Val Leu 
            900                 905                 910         


Thr Ser Gln Leu Gln Ala Cys Arg Glu Ala Ser Gln His Arg Ala Leu 
        915                 920                 925             


Glu Gln Ser Gln Ser Leu Pro Leu Pro Ala Pro Thr Ser Thr Ser Pro 
    930                 935                 940                 


Ser Arg Gly Asn Ser Arg Asn Ile Lys Lys Leu Glu Glu Arg Lys Thr 
945                 950                 955                 960 


Asp Pro Leu Ser Leu Glu Gly Tyr Val Ser Ser Ala Pro Leu Thr Lys 
                965                 970                 975     


Pro Pro Glu Lys Gly Lys Glu Pro 
            980                 


<210>  8454
<211>  86
<212>  PRT
<213>  Homo Sapiens

<400>  8454

Met Trp Leu Ser Gln Arg Val Leu Pro Pro Leu Pro Phe Pro Ala Asp 
1               5                   10                  15      


Ala Trp Glu Pro Ser Glu Val Leu Gly Ile Phe Ser Gln His Arg Ser 
            20                  25                  30          


His Ala Thr Thr Ser Glu Ser Leu Thr Trp Thr Ser Thr Gly Thr Ser 
        35                  40                  45              


Asp Ala Arg Thr Gly Val Ile Leu Gln Asp Ala Gly Ile Gly Phe Ile 
    50                  55                  60                  


Leu Val Ile Asp Arg Arg Arg Asp Lys Trp Thr Ser Val Lys Ala Ser 
65                  70                  75                  80  


Val Leu Arg Ile Ala Asn 
                85      


<210>  8455
<211>  93
<212>  PRT
<213>  Homo Sapiens

<400>  8455

Ser Pro Val Ile Thr Phe Pro Asp Tyr Pro Ala Phe Ser Glu Ile Pro 
1               5                   10                  15      


Asp Lys Glu Phe Gln Asn Val Met Thr Tyr Leu Thr Ser Ile Pro Ser 
            20                  25                  30          


Ile Leu Phe Met Glu Ser Ala Ala Ser Glu His Trp Gly Gln Val Ala 
        35                  40                  45              


Glu Ala Leu Pro Phe Leu Pro Pro Gly Ser Ala Arg Thr Ala Val Thr 
    50                  55                  60                  


Thr Ser Pro Arg Gly Pro Leu Pro Ala Pro Ser Gln Asn Val Phe Pro 
65                  70                  75                  80  


Arg Ser Phe Ser Val Thr Ala Val Glu Phe Asn Ser Tyr 
                85                  90              


<210>  8456
<211>  213
<212>  PRT
<213>  Homo Sapiens

<400>  8456

Thr Ser Thr Gly Thr Ser Asp Ala Arg Thr Gly Val Ile Leu Gln Asp 
1               5                   10                  15      


Ala Gly Ile Gly Phe Ile Leu Val Ile Asp Arg Arg Arg Asp Lys Trp 
            20                  25                  30          


Thr Ser Val Lys Ala Ser Val Leu Arg Ile Ala Ala Ser Phe Pro Ala 
        35                  40                  45              


Asn Leu Gln Leu Val Leu Val Leu Arg Pro Thr Gly Phe Phe Gln Arg 
    50                  55                  60                  


Thr Leu Ser Asp Ile Ala Phe Lys Phe Asn Arg Asp Asp Phe Lys Met 
65                  70                  75                  80  


Lys Val Pro Val Ile Met Leu Ser Ser Val Pro Asp Leu His Gly Tyr 
                85                  90                  95      


Ile Asp Lys Ser Gln Leu Thr Glu Asp Leu Gly Gly Thr Leu Asp Tyr 
            100                 105                 110         


Cys His Ser Arg Trp Leu Cys Gln Arg Thr Ala Ile Glu Ser Phe Ala 
        115                 120                 125             


Leu Met Val Lys Gln Thr Ala Gln Met Leu Gln Ser Phe Gly Thr Glu 
    130                 135                 140                 


Leu Ala Glu Thr Glu Leu Pro Asn Asp Val Gln Ser Thr Ser Ser Val 
145                 150                 155                 160 


Leu Cys Ala His Thr Glu Lys Lys Asp Lys Ala Lys Val His Gly Gly 
                165                 170                 175     


Cys Ser Gly Trp Lys Leu Trp Gly Ala Pro Val Ser Gln Lys Leu Arg 
            180                 185                 190         


Gly Ala Pro Val Gly Ser Cys Gly Gly Ser Phe Val Pro Ala Gly Val 
        195                 200                 205             


Cys Val Ser Ser Thr 
    210             


<210>  8457
<211>  336
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8457

Xaa Glu Asn Gly Glu Gly Tyr Glu Lys Ala Pro Ser Tyr Ser Tyr Lys 
1               5                   10                  15      


Gln Ser Leu Asn Met Ala Ala Val Gly Ile Thr Glu Asn Val Lys Gly 
            20                  25                  30          


Asp Ala Lys Lys Phe Glu Ile Trp Tyr Asn Ala Arg Glu Glu Val Tyr 
        35                  40                  45              


Ile Val Gln Ala Pro Thr Pro Glu Ile Lys Ala Ala Trp Val Asn Glu 
    50                  55                  60                  


Ile Arg Lys Val Leu Thr Ser Gln Leu Gln Ala Cys Arg Glu Ala Ser 
65                  70                  75                  80  


Gln His Arg Ala Leu Glu Gln Ser Gln Ser Leu Pro Leu Pro Ala Pro 
                85                  90                  95      


Thr Ser Thr Ser Pro Ser Arg Gly Asn Ser Arg Asn Ile Lys Lys Leu 
            100                 105                 110         


Glu Glu Arg Lys Thr Asp Pro Leu Ser Leu Glu Gly Tyr Val Ser Ser 
        115                 120                 125             


Ala Pro Leu Thr Lys Pro Pro Glu Lys Gly Lys Asp Asp Thr Val Thr 
    130                 135                 140                 


Ser Ser Ala Ser Glu Ser Ser Ala Leu Ser Arg Lys Arg Phe Thr Leu 
145                 150                 155                 160 


Gln Gly Phe Ala Asn Leu Lys Gly Gln Lys Ala Ser Pro Thr Ser Pro 
                165                 170                 175     


Asp Lys Lys Ala Lys Arg His Glu Val Lys Ser Asp Pro Thr Pro Phe 
            180                 185                 190         


Gly Val Arg Gly Trp Ser Lys Thr Ser His Ser Leu Glu Ala Pro Glu 
        195                 200                 205             


Asp Asp Gly Gly Trp Ser Ser Ala Glu Glu Gln Ile Asn Ser Ser Asp 
    210                 215                 220                 


Ala Glu Glu Asp Gly Gly Leu Gly Pro Lys Lys Leu Val Pro Gly Lys 
225                 230                 235                 240 


Tyr Thr Val Val Ala Asp His Glu Lys Gly Gly Pro Asp Ala Leu Arg 
                245                 250                 255     


Val Arg Ser Gly Asp Val Val Glu Leu Val Gln Glu Gly Asp Glu Gly 
            260                 265                 270         


Leu Trp Tyr Val Arg Asp Pro Thr Thr Gly Lys Glu Gly Trp Val Pro 
        275                 280                 285             


Ala Ser Ser Leu Ser Val Arg Leu Gly Pro Ser Gly Ser Ala Gln Cys 
    290                 295                 300                 


Leu Ser Ser Ser Glu Ser Ser Pro Gly Ser Ala Val Leu Ser Asn Ser 
305                 310                 315                 320 


Ser Ser Cys Ser Glu Gly Gly Gln Ala Pro Phe Ser Asp Leu Gln Gly 
                325                 330                 335     


<210>  8458
<211>  296
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8458

Xaa His Leu Phe Leu His Glu Lys Ala Val Leu Phe Cys Lys Lys Arg 
1               5                   10                  15      


Glu Glu Asn Gly Glu Gly Tyr Glu Lys Ala Pro Ser Tyr Ser Tyr Lys 
            20                  25                  30          


Gln Ser Leu Asn Met Ala Ala Val Gly Ile Thr Glu Asn Val Lys Gly 
        35                  40                  45              


Asp Ala Lys Lys Phe Glu Ile Trp Tyr Asn Ala Arg Glu Glu Val Tyr 
    50                  55                  60                  


Ile Val Gln Ala Pro Thr Pro Glu Ile Lys Ala Ala Trp Val Asn Glu 
65                  70                  75                  80  


Ile Arg Lys Val Leu Thr Ser Gln Leu Gln Ala Cys Arg Glu Ala Ser 
                85                  90                  95      


Gln His Arg Ala Leu Glu Gln Ser Gln Ser Leu Pro Leu Pro Ala Pro 
            100                 105                 110         


Thr Ser Thr Ser Pro Ser Arg Gly Asn Ser Arg Asn Ile Lys Lys Leu 
        115                 120                 125             


Glu Glu Arg Lys Thr Asp Pro Leu Ser Leu Glu Gly Tyr Val Ser Ser 
    130                 135                 140                 


Ala Pro Leu Thr Lys Pro Pro Glu Lys Gly Lys Gly Trp Ser Lys Thr 
145                 150                 155                 160 


Ser His Ser Leu Glu Ala Pro Glu Asp Asp Gly Gly Trp Ser Ser Ala 
                165                 170                 175     


Glu Glu Gln Ile Asn Ser Ser Asp Ala Glu Glu Asp Gly Gly Leu Gly 
            180                 185                 190         


Pro Lys Lys Leu Val Pro Gly Lys Tyr Thr Val Val Ala Asp His Glu 
        195                 200                 205             


Lys Gly Gly Pro Asp Ala Leu Arg Val Arg Ser Gly Asp Val Val Glu 
    210                 215                 220                 


Leu Val Gln Glu Gly Asp Glu Gly Leu Trp Tyr Val Arg Asp Pro Thr 
225                 230                 235                 240 


Thr Gly Lys Glu Gly Trp Val Pro Ala Ser Ser Leu Ser Val Arg Leu 
                245                 250                 255     


Gly Pro Ser Gly Ser Ala Gln Cys Leu Ser Ser Ser Glu Ser Ser Pro 
            260                 265                 270         


Gly Ser Ala Val Leu Ser Asn Ser Ser Ser Cys Ser Glu Gly Gly Gln 
        275                 280                 285             


Ala Pro Phe Ser Asp Leu Gln Gly 
    290                 295     


<210>  8459
<211>  189
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8459

Xaa Lys Lys Leu Glu Glu Arg Lys Thr Asp Pro Leu Ser Leu Glu Gly 
1               5                   10                  15      


Tyr Val Ser Ser Ala Pro Leu Thr Lys Pro Pro Glu Lys Gly Lys Ala 
            20                  25                  30          


Ser Pro Thr Ser Pro Asp Lys Lys Ala Lys Arg His Glu Val Lys Ser 
        35                  40                  45              


Asp Pro Thr Pro Phe Gly Val Arg Gly Trp Ser Lys Thr Ser His Ser 
    50                  55                  60                  


Leu Glu Ala Pro Glu Asp Asp Gly Gly Trp Ser Ser Ala Glu Glu Gln 
65                  70                  75                  80  


Ile Asn Ser Ser Asp Ala Glu Glu Asp Gly Gly Leu Gly Pro Lys Lys 
                85                  90                  95      


Leu Val Pro Gly Lys Tyr Thr Val Val Ala Asp His Glu Lys Gly Gly 
            100                 105                 110         


Pro Asp Ala Leu Arg Val Arg Ser Gly Asp Val Val Glu Leu Val Gln 
        115                 120                 125             


Glu Gly Asp Glu Gly Leu Trp Tyr Val Arg Asp Pro Thr Thr Gly Lys 
    130                 135                 140                 


Glu Gly Trp Val Pro Ala Ser Ser Leu Ser Val Arg Leu Gly Pro Ser 
145                 150                 155                 160 


Gly Ser Ala Gln Cys Leu Ser Ser Ser Glu Ser Ser Pro Gly Ser Ala 
                165                 170                 175     


Val Leu Ser Asn Ser Ser Ser Cys Ser Glu Gly Gly Gln 
            180                 185                 


<210>  8460
<211>  317
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8460

Xaa Leu Gly Ile Leu Lys Ala Val Asn Asp Ser Met His Leu Ile Ala 
1               5                   10                  15      


Ile Thr Gly Tyr Asp Gly Asn Leu Gly Asp Leu Gly Lys Leu Leu Met 
            20                  25                  30          


Gln Gly Ser Phe Ser Val Trp Thr Asp His Lys Arg Gly His Thr Lys 
        35                  40                  45              


Val Lys Glu Leu Ala Arg Phe Lys Pro Met Gln Arg His Leu Phe Leu 
    50                  55                  60                  


His Glu Lys Ala Val Leu Phe Cys Lys Lys Arg Glu Glu Asn Gly Glu 
65                  70                  75                  80  


Gly Tyr Glu Lys Ala Pro Ser Tyr Ser Tyr Lys Gln Ser Leu Asn Met 
                85                  90                  95      


Ala Ala Val Gly Ile Thr Glu Asn Val Lys Gly Asp Ala Lys Lys Phe 
            100                 105                 110         


Glu Ile Trp Tyr Asn Ala Arg Glu Glu Val Tyr Ile Val Gln Ala Pro 
        115                 120                 125             


Thr Pro Glu Ile Lys Ala Ala Trp Val Asn Glu Ile Arg Lys Val Leu 
    130                 135                 140                 


Thr Ser Gln Leu Gln Ala Cys Arg Glu Ala Ser Gln His Arg Ala Leu 
145                 150                 155                 160 


Glu Gln Ser Gln Ser Leu Pro Leu Pro Ala Pro Thr Ser Thr Ser Pro 
                165                 170                 175     


Ser Arg Gly Asn Ser Arg Asn Ile Lys Lys Leu Glu Glu Arg Lys Thr 
            180                 185                 190         


Asp Pro Leu Ser Leu Glu Gly Tyr Val Ser Ser Ala Pro Leu Thr Lys 
        195                 200                 205             


Pro Pro Glu Lys Gly Lys Asp Asp Thr Val Thr Ser Ser Ala Ser Glu 
    210                 215                 220                 


Ser Ser Ala Leu Ser Arg Lys Arg Phe Thr Leu Gln Gly Phe Ala Asn 
225                 230                 235                 240 


Leu Lys Ala Ser Pro Thr Ser Pro Asp Lys Lys Ala Lys Arg His Glu 
                245                 250                 255     


Val Lys Ser Asp Pro Thr Pro Phe Gly Val Arg Gly Trp Ser Lys Thr 
            260                 265                 270         


Ser His Ser Leu Glu Ala Pro Glu Asp Asp Gly Gly Trp Ser Ser Ala 
        275                 280                 285             


Glu Glu Gln Ile Asn Ser Ser Asp Ala Glu Glu Asp Gly Gly Leu Gly 
    290                 295                 300                 


Pro Lys Lys Leu Val Pro Gly Lys Tyr Thr Val Val Ala 
305                 310                 315         


<210>  8461
<211>  151
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8461

Xaa Gln Ala Pro Thr Pro Glu Ile Lys Ala Ala Trp Val Asn Glu Ile 
1               5                   10                  15      


Arg Lys Val Leu Thr Ser Gln Leu Gln Ala Cys Arg Glu Ala Ser Gln 
            20                  25                  30          


His Arg Ala Leu Glu Gln Ser Gln Ser Leu Pro Leu Pro Ala Pro Thr 
        35                  40                  45              


Ser Thr Ser Pro Ser Arg Gly Asn Ser Arg Asn Ile Lys Lys Leu Glu 
    50                  55                  60                  


Glu Arg Lys Thr Asp Pro Leu Ser Leu Glu Gly Tyr Val Ser Ser Ala 
65                  70                  75                  80  


Pro Leu Thr Lys Pro Pro Glu Lys Gly Lys Asp Asp Thr Val Thr Ser 
                85                  90                  95      


Ser Ala Ser Glu Ser Ser Ala Leu Ser Arg Lys Arg Phe Thr Leu Gln 
            100                 105                 110         


Gly Phe Ala Asn Leu Lys Gly Gln Lys Gly Trp Ser Lys Thr Ser His 
        115                 120                 125             


Ser Leu Glu Ala Pro Glu Asp Asp Gly Gly Trp Ser Ser Ala Glu Glu 
    130                 135                 140                 


Gln Ile Asn Ser Ser Asp Ala 
145                 150     


<210>  8462
<211>  87
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8462

Xaa Ser Ala Pro Leu Thr Lys Pro Pro Glu Lys Gly Lys Gly Trp Ser 
1               5                   10                  15      


Lys Thr Ser His Ser Leu Glu Ala Pro Glu Asp Asp Gly Gly Trp Ser 
            20                  25                  30          


Ser Ala Glu Glu Gln Ile Asn Ser Ser Asp Ala Glu Glu Asp Gly Gly 
        35                  40                  45              


Leu Gly Pro Lys Lys Leu Val Pro Thr Gln Pro Pro Val Glu Pro Thr 
    50                  55                  60                  


Arg Gly Cys Thr Phe Leu Arg Gly Asp Ser Pro His Pro Pro Thr Leu 
65                  70                  75                  80  


Tyr Val Ile Glu Cys Cys His 
                85          


<210>  8463
<211>  69
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8463

Xaa Ser Glu Ile Pro Asp Lys Glu Phe Gln Asn Val Met Thr Tyr Leu 
1               5                   10                  15      


Thr Ser Ile Pro Ser Leu Gln Asp Ala Gly Ile Gly Phe Ile Leu Val 
            20                  25                  30          


Ile Asp Arg Arg Arg Asp Lys Trp Thr Ser Val Lys Ala Ser Val Leu 
        35                  40                  45              


Arg Ile Ala Leu Arg Ala Arg Cys Thr Glu Ser Glu Pro Leu His Pro 
    50                  55                  60                  


Gly Gly Ser Gly Ile 
65                  


<210>  8464
<211>  793
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8464

Xaa Ser Gln Lys Ile Ala Thr Phe Thr Asp Ile Gly Asn Ser Leu Ala 
1               5                   10                  15      


His Val Glu His Leu Leu Arg Asp Leu Ala Ser Phe Glu Glu Lys Ser 
            20                  25                  30          


Gly Val Ala Val Glu Arg Ala Arg Ala Leu Ser Leu Asp Gly Glu Gln 
        35                  40                  45              


Leu Ile Gly Asn Lys His Tyr Ala Val Asp Ser Ile Arg Pro Lys Cys 
    50                  55                  60                  


Gln Glu Leu Arg His Leu Cys Asp Gln Phe Ser Ala Glu Ile Ala Arg 
65                  70                  75                  80  


Arg Arg Gly Leu Leu Ser Lys Ser Leu Glu Leu His Arg Arg Leu Glu 
                85                  90                  95      


Thr Ser Met Lys Trp Cys Asp Glu Gly Ile Tyr Leu Leu Ala Ser Gln 
            100                 105                 110         


Pro Val Asp Lys Cys Gln Ser Gln Asp Gly Ala Glu Ala Ala Leu Gln 
        115                 120                 125             


Glu Ile Glu Lys Phe Leu Glu Thr Gly Ala Glu Asn Lys Ile Gln Glu 
    130                 135                 140                 


Leu Asn Ala Ile Tyr Lys Glu Tyr Glu Ser Ile Leu Asn Gln Asp Leu 
145                 150                 155                 160 


Met Glu His Val Arg Lys Val Phe Gln Lys Gln Ala Ser Met Glu Glu 
                165                 170                 175     


Val Phe His Arg Arg Gln Ala Ser Leu Lys Lys Leu Ala Ala Arg Gln 
            180                 185                 190         


Thr Arg Pro Val Gln Pro Val Ala Pro Arg Pro Glu Ala Leu Ala Lys 
        195                 200                 205             


Ser Pro Cys Pro Ser Pro Gly Ile Arg Arg Gly Ser Glu Asn Ser Ser 
    210                 215                 220                 


Ser Glu Gly Gly Ala Leu Arg Arg Gly Pro Tyr Arg Arg Ala Lys Ser 
225                 230                 235                 240 


Glu Met Ser Glu Ser Arg Gln Gly Arg Gly Ser Ala Gly Glu Glu Glu 
                245                 250                 255     


Glu Ser Leu Ala Ile Leu Arg Arg His Val Met Ser Glu Leu Leu Asp 
            260                 265                 270         


Thr Glu Arg Ala Tyr Val Glu Glu Leu Leu Cys Val Leu Glu Gly Tyr 
        275                 280                 285             


Ala Ala Glu Met Asp Asn Pro Leu Met Ala His Leu Leu Ser Thr Gly 
    290                 295                 300                 


Leu His Asn Lys Lys Asp Val Leu Phe Gly Asn Met Glu Glu Ile Tyr 
305                 310                 315                 320 


His Phe His Asn Arg Ile Phe Leu Arg Glu Leu Glu Asn Tyr Thr Asp 
                325                 330                 335     


Cys Pro Glu Leu Val Gly Arg Cys Phe Leu Glu Arg Met Glu Asp Phe 
            340                 345                 350         


Gln Ile Tyr Glu Lys Tyr Cys Gln Asn Lys Pro Arg Ser Glu Ser Leu 
        355                 360                 365             


Trp Arg Gln Cys Ser Asp Cys Pro Phe Phe Gln Glu Cys Gln Arg Lys 
    370                 375                 380                 


Leu Asp His Lys Leu Ser Leu Asp Ser Tyr Leu Leu Lys Pro Val Gln 
385                 390                 395                 400 


Arg Ile Thr Lys Tyr Gln Leu Leu Leu Lys Glu Met Leu Lys Tyr Ser 
                405                 410                 415     


Arg Asn Cys Glu Gly Ala Glu Asp Leu Gln Glu Ala Leu Ser Ser Ile 
            420                 425                 430         


Leu Gly Ile Leu Lys Ala Val Asn Asp Ser Met His Leu Ile Ala Ile 
        435                 440                 445             


Thr Gly Tyr Asp Gly Asn Leu Gly Asp Leu Gly Lys Leu Leu Met Gln 
    450                 455                 460                 


Gly Ser Phe Ser Val Trp Thr Asp His Lys Arg Gly His Thr Lys Val 
465                 470                 475                 480 


Lys Glu Leu Ala Arg Phe Lys Pro Met Gln Arg His Leu Phe Leu His 
                485                 490                 495     


Glu Lys Ala Val Leu Phe Cys Lys Lys Arg Glu Glu Asn Gly Glu Gly 
            500                 505                 510         


Tyr Glu Lys Ala Pro Ser Tyr Ser Tyr Lys Gln Ser Leu Asn Met Ala 
        515                 520                 525             


Ala Val Gly Ile Thr Glu Asn Val Lys Gly Asp Ala Lys Lys Phe Glu 
    530                 535                 540                 


Ile Trp Tyr Asn Ala Arg Glu Glu Val Tyr Ile Val Gln Ala Pro Thr 
545                 550                 555                 560 


Pro Glu Ile Lys Ala Ala Trp Val Asn Glu Ile Arg Lys Val Leu Thr 
                565                 570                 575     


Ser Gln Leu Gln Ala Cys Arg Glu Ala Ser Gln His Arg Ala Leu Glu 
            580                 585                 590         


Gln Ser Gln Ser Leu Pro Leu Pro Ala Pro Thr Ser Thr Ser Pro Ser 
        595                 600                 605             


Arg Gly Asn Ser Arg Asn Ile Lys Lys Leu Glu Glu Arg Lys Thr Asp 
    610                 615                 620                 


Pro Leu Ser Leu Glu Gly Tyr Val Ser Ser Ala Pro Leu Thr Lys Pro 
625                 630                 635                 640 


Pro Glu Lys Gly Lys Ala Ser Pro Thr Ser Pro Asp Lys Lys Ala Lys 
                645                 650                 655     


Arg His Glu Val Lys Ser Asp Pro Thr Pro Phe Gly Val Arg Gly Trp 
            660                 665                 670         


Ser Lys Thr Ser His Ser Leu Glu Ala Pro Glu Asp Asp Gly Gly Trp 
        675                 680                 685             


Ser Ser Ala Glu Glu Gln Ile Asn Ser Ser Asp Ala Glu Glu Asp Gly 
    690                 695                 700                 


Gly Leu Gly Pro Lys Lys Leu Val Pro Gly Lys Tyr Thr Val Val Ala 
705                 710                 715                 720 


Asp His Glu Lys Gly Gly Pro Asp Ala Leu Arg Val Arg Ser Gly Asp 
                725                 730                 735     


Val Val Glu Leu Val Gln Glu Gly Asp Glu Gly Leu Trp Tyr Val Arg 
            740                 745                 750         


Asp Pro Thr Thr Gly Lys Glu Gly Trp Val Pro Ala Ser Ser Leu Ser 
        755                 760                 765             


Val Arg Leu Gly Pro Ser Gly Ser Ala Gln Cys Leu Ser Ser Ser Gly 
    770                 775                 780                 


Lys Ala His Val Pro Arg Ala His Pro 
785                 790             


<210>  8465
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  8465

Met Glu His Leu Glu Gly Val Ile Asn Lys Pro Glu Ala Glu Met Ser 
1               5                   10                  15      


Pro Gln Glu Leu Gln Leu His Tyr Phe Lys Met His Asp Tyr Asp Gly 
            20                  25                  30          


Asn Asn Leu Leu Asp Gly Leu Glu Leu Ser Thr Ala Ile Thr His Val 
        35                  40                  45              


His Lys Glu Glu Gly Ser Glu Gln Ala Pro Leu Met Ser Glu Asp Glu 
    50                  55                  60                  


Leu Ile Asn Ile Ile Asp Gly Val Leu Arg Asp Asp Asp Lys Asn Asn 
65                  70                  75                  80  


Asp Gly Tyr Ile Asp Tyr Ala Glu Phe Ala Lys Ser Leu Gln 
                85                  90                  


<210>  8466
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  8466

Met Glu His Leu Glu Gly Val Ile Asn Lys Pro Glu Ala Glu Met Ser 
1               5                   10                  15      


Pro Gln Glu Leu Gln Leu His Tyr Phe Lys Met His Asp Tyr Asp Gly 
            20                  25                  30          


Asn Asn Leu Leu Asp Gly Leu Glu Leu Ser Thr Ala Ile Thr His Val 
        35                  40                  45              


His Lys Glu Glu Gly Ser Glu Gln Ala Pro Leu Met Ser Glu Asp Glu 
    50                  55                  60                  


Leu Ile Asn Ile Ile Asp Gly Val Leu Arg Asp Asp Asp Lys Asn Asn 
65                  70                  75                  80  


Asp Gly Tyr Ile Asp Tyr Ala Glu Phe Ala Lys Ser Leu Gln 
                85                  90                  


<210>  8467
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  8467

Met Glu His Leu Glu Gly Val Ile Asn Lys Pro Glu Ala Glu Met Ser 
1               5                   10                  15      


Pro Gln Glu Leu Gln Leu His Tyr Phe Lys Met His Asp Tyr Asp Gly 
            20                  25                  30          


Asn Asn Leu Leu Asp Gly Leu Glu Leu Ser Thr Ala Ile Thr His Val 
        35                  40                  45              


His Lys Glu Glu Gly Ser Glu Gln Ala Pro Leu Met Ser Glu Asp Glu 
    50                  55                  60                  


Leu Ile Asn Ile Ile Asp Gly Val Leu Arg Asp Asp Asp Lys Asn Asn 
65                  70                  75                  80  


Asp Gly Tyr Ile Asp Tyr Ala Glu Phe Ala Lys Ser Leu Gln 
                85                  90                  


<210>  8468
<211>  127
<212>  PRT
<213>  Homo Sapiens

<400>  8468

Met Leu Ser Val Cys Ser Cys Arg Thr Ser Ser Gly Met Arg Ser Gln 
1               5                   10                  15      


Trp Pro Ser Ala Arg Gln Arg Ser Ser Ser Leu Ser Thr Phe Arg His 
            20                  25                  30          


Ile Met Glu His Leu Glu Gly Val Ile Asn Lys Pro Glu Ala Glu Met 
        35                  40                  45              


Ser Pro Gln Glu Leu Gln Leu His Tyr Phe Lys Met His Asp Tyr Asp 
    50                  55                  60                  


Gly Asn Asn Leu Leu Asp Gly Leu Glu Leu Ser Thr Ala Ile Thr His 
65                  70                  75                  80  


Val His Lys Glu Glu Gly Ser Glu Gln Ala Pro Leu Met Ser Glu Asp 
                85                  90                  95      


Glu Leu Ile Asn Ile Ile Asp Gly Val Leu Arg Asp Asp Asp Lys Asn 
            100                 105                 110         


Asn Asp Gly Tyr Ile Asp Tyr Ala Glu Phe Ala Lys Ser Leu Gln 
        115                 120                 125         


<210>  8469
<211>  61
<212>  PRT
<213>  Homo Sapiens

<400>  8469

Met Thr Met Arg Ser Leu Leu Arg Thr Pro Phe Leu Cys Gly Leu Leu 
1               5                   10                  15      


Trp Ala Phe Cys Ala Pro Gly Ala Arg Ala Glu Glu Pro Ala Ala Ser 
            20                  25                  30          


Phe Ser Gln Pro Gly Ser Met Gly Leu Asp Lys Asn Thr Val His Asp 
        35                  40                  45              


Gln Glu His Ile Met Glu His Leu Glu Gly Val Ile Asn 
    50                  55                  60      


<210>  8470
<211>  146
<212>  PRT
<213>  Homo Sapiens

<400>  8470

Met Thr Met Arg Ser Leu Leu Arg Thr Pro Phe Leu Cys Gly Leu Leu 
1               5                   10                  15      


Trp Ala Phe Cys Ala Pro Gly Ala Arg Ala Glu Glu Pro Ala Ala Ser 
            20                  25                  30          


Phe Ser Gln Pro Gly Ser Met Gly Leu Asp Lys Asn Thr Val His Asp 
        35                  40                  45              


Gln Glu His Ile Met Glu His Leu Glu Gly Val Ile Asn Lys Pro Glu 
    50                  55                  60                  


Ala Glu Met Ser Pro Gln Glu Leu Gln Leu His Tyr Phe Lys Met His 
65                  70                  75                  80  


Asp Tyr Asp Gly Asn Asn Leu Leu Asp Gly Leu Glu Leu Ser Thr Ala 
                85                  90                  95      


Ile Thr His Val His Lys Glu Glu Gly Ser Glu Gln Ala Pro Leu Met 
            100                 105                 110         


Ser Glu Asp Glu Leu Ile Asn Ile Ile Asp Gly Val Leu Arg Asp Asp 
        115                 120                 125             


Asp Lys Asn Asn Asp Gly Tyr Ile Asp Tyr Ala Glu Phe Ala Lys Ser 
    130                 135                 140                 


Leu Gln 
145     


<210>  8471
<211>  146
<212>  PRT
<213>  Homo Sapiens

<400>  8471

Met Thr Met Arg Ser Leu Leu Arg Thr Pro Phe Leu Cys Gly Leu Leu 
1               5                   10                  15      


Trp Ala Phe Cys Ala Pro Gly Ala Arg Ala Glu Glu Pro Ala Ala Ser 
            20                  25                  30          


Phe Ser Gln Pro Gly Ser Met Gly Leu Asp Lys Asn Thr Val His Asp 
        35                  40                  45              


Gln Glu His Ile Met Glu His Leu Glu Gly Val Ile Asn Lys Pro Glu 
    50                  55                  60                  


Ala Glu Met Ser Pro Gln Glu Leu Gln Leu His Tyr Phe Lys Met His 
65                  70                  75                  80  


Asp Tyr Asp Gly Asn Asn Leu Leu Asp Gly Leu Glu Leu Ser Thr Ala 
                85                  90                  95      


Ile Thr His Val His Lys Glu Glu Gly Ser Glu Gln Ala Pro Leu Met 
            100                 105                 110         


Ser Glu Asp Glu Leu Ile Asn Ile Ile Asp Gly Val Leu Arg Asp Asp 
        115                 120                 125             


Asp Lys Asn Asn Asp Gly Tyr Ile Asp Tyr Ala Glu Phe Ala Lys Ser 
    130                 135                 140                 


Leu Gln 
145     


<210>  8472
<211>  146
<212>  PRT
<213>  Homo Sapiens

<400>  8472

Met Thr Met Arg Ser Leu Leu Arg Thr Pro Phe Leu Cys Gly Leu Leu 
1               5                   10                  15      


Trp Ala Phe Cys Ala Pro Gly Ala Arg Ala Glu Glu Pro Ala Ala Ser 
            20                  25                  30          


Phe Ser Gln Pro Gly Ser Met Gly Leu Asp Lys Asn Thr Val His Asp 
        35                  40                  45              


Gln Glu His Ile Met Glu His Leu Glu Gly Val Ile Asn Lys Pro Glu 
    50                  55                  60                  


Ala Glu Met Ser Pro Gln Glu Leu Gln Leu His Tyr Phe Lys Met His 
65                  70                  75                  80  


Asp Tyr Asp Gly Asn Asn Leu Leu Asp Gly Leu Glu Leu Ser Thr Ala 
                85                  90                  95      


Ile Thr His Val His Lys Glu Glu Gly Ser Glu Gln Ala Pro Leu Met 
            100                 105                 110         


Ser Glu Asp Glu Leu Ile Asn Ile Ile Asp Gly Val Leu Arg Asp Asp 
        115                 120                 125             


Asp Lys Asn Asn Asp Gly Tyr Ile Asp Tyr Ala Glu Phe Ala Lys Ser 
    130                 135                 140                 


Leu Gln 
145     


<210>  8473
<211>  146
<212>  PRT
<213>  Homo Sapiens

<400>  8473

Met Thr Met Arg Ser Leu Leu Arg Thr Pro Phe Leu Cys Gly Leu Leu 
1               5                   10                  15      


Trp Ala Phe Cys Ala Pro Gly Ala Arg Ala Glu Glu Pro Ala Ala Ser 
            20                  25                  30          


Phe Ser Gln Pro Gly Ser Met Gly Leu Asp Lys Asn Thr Val His Asp 
        35                  40                  45              


Gln Glu His Ile Met Glu His Leu Glu Gly Val Ile Asn Lys Pro Glu 
    50                  55                  60                  


Ala Glu Met Ser Pro Gln Glu Leu Gln Leu His Tyr Phe Lys Met His 
65                  70                  75                  80  


Asp Tyr Asp Gly Asn Asn Leu Leu Asp Gly Leu Glu Leu Ser Thr Ala 
                85                  90                  95      


Ile Thr His Val His Lys Glu Glu Gly Ser Glu Gln Ala Pro Leu Met 
            100                 105                 110         


Ser Glu Asp Glu Leu Ile Asn Ile Ile Asp Gly Val Leu Arg Asp Asp 
        115                 120                 125             


Asp Lys Asn Asn Asp Gly Tyr Ile Asp Tyr Ala Glu Phe Ala Lys Ser 
    130                 135                 140                 


Leu Gln 
145     


<210>  8474
<211>  146
<212>  PRT
<213>  Homo Sapiens

<400>  8474

Met Thr Met Arg Ser Leu Leu Arg Thr Pro Phe Leu Cys Gly Leu Leu 
1               5                   10                  15      


Trp Ala Phe Cys Ala Pro Gly Ala Arg Ala Glu Glu Pro Ala Ala Ser 
            20                  25                  30          


Phe Ser Gln Pro Gly Ser Met Gly Leu Asp Lys Asn Thr Val His Asp 
        35                  40                  45              


Gln Glu His Ile Met Glu His Leu Glu Gly Val Ile Asn Lys Pro Glu 
    50                  55                  60                  


Ala Glu Met Ser Pro Gln Glu Leu Gln Leu His Tyr Phe Lys Met His 
65                  70                  75                  80  


Asp Tyr Asp Gly Asn Asn Leu Leu Asp Gly Leu Glu Leu Ser Thr Ala 
                85                  90                  95      


Ile Thr His Val His Lys Glu Glu Gly Ser Glu Gln Ala Pro Leu Met 
            100                 105                 110         


Ser Glu Asp Glu Leu Ile Asn Ile Ile Asp Gly Val Leu Arg Asp Asp 
        115                 120                 125             


Asp Lys Asn Asn Asp Gly Tyr Ile Asp Tyr Ala Glu Phe Ala Lys Ser 
    130                 135                 140                 


Leu Gln 
145     


<210>  8475
<211>  146
<212>  PRT
<213>  Homo Sapiens

<400>  8475

Met Thr Met Arg Ser Leu Leu Arg Thr Pro Phe Leu Cys Gly Leu Leu 
1               5                   10                  15      


Trp Ala Phe Cys Ala Pro Gly Ala Arg Ala Glu Glu Pro Ala Ala Ser 
            20                  25                  30          


Phe Ser Gln Pro Gly Ser Met Gly Leu Asp Lys Asn Thr Val His Asp 
        35                  40                  45              


Gln Glu His Ile Met Glu His Leu Glu Gly Val Ile Asn Lys Pro Glu 
    50                  55                  60                  


Ala Glu Met Ser Pro Gln Glu Leu Gln Leu His Tyr Phe Lys Met His 
65                  70                  75                  80  


Asp Tyr Asp Gly Asn Asn Leu Leu Asp Gly Leu Glu Leu Ser Thr Ala 
                85                  90                  95      


Ile Thr His Val His Lys Glu Glu Gly Ser Glu Gln Ala Pro Leu Met 
            100                 105                 110         


Ser Glu Asp Glu Leu Ile Asn Ile Ile Asp Gly Val Leu Arg Asp Asp 
        115                 120                 125             


Asp Lys Asn Asn Asp Gly Tyr Ile Asp Tyr Ala Glu Phe Ala Lys Ser 
    130                 135                 140                 


Leu Gln 
145     


<210>  8476
<211>  90
<212>  PRT
<213>  Homo Sapiens

<400>  8476

Ser Gln Pro Gly Ser Met Gly Leu Asp Lys Asn Thr Val His Asp Gln 
1               5                   10                  15      


Glu His Ile Met Glu His Leu Glu Gly Val Ile Asn Lys Pro Glu Ala 
            20                  25                  30          


Glu Met Ser Pro Gln Glu Leu Gln Leu His Tyr Phe Lys Met His Asp 
        35                  40                  45              


Tyr Asp Gly Asn Asn Leu Leu Asp Gly Leu Glu Leu Ser Thr Ala Ile 
    50                  55                  60                  


Thr His Val His Lys Glu Ala Asn Leu Cys Thr Glu Leu Thr Leu Arg 
65                  70                  75                  80  


Arg Thr Gly Thr Phe Pro Ile Lys Glu Glu 
                85                  90  


<210>  8477
<211>  156
<212>  PRT
<213>  Homo Sapiens

<400>  8477

Gly Pro Val Gly Pro Gln Arg Val Ala Glu Ala Gly Gly Gly Gln Leu 
1               5                   10                  15      


Gly Ser Thr Ala Gln Gly Lys Cys Asp Lys Asp Asn Thr Glu Lys Asp 
            20                  25                  30          


Ile Thr Gln Ala Thr Asn Ser His Phe Thr His Gly Glu Met Gln Asp 
        35                  40                  45              


Gln Ser Ile Trp Gly Asn Pro Ser Asp Gly Glu Leu Ile Arg Thr Gln 
    50                  55                  60                  


Pro Gln Arg Leu Pro Gln Leu Gln Thr Ser Ala Gln Val Pro Ser Gly 
65                  70                  75                  80  


Glu Glu Ile Gly Lys Ile Lys Asn Gly His Thr Gly Leu Ser Asn Gly 
                85                  90                  95      


Asn Gly Ile His His Gly Ala Lys His Gly Ser Ala Asp Asn Arg Lys 
            100                 105                 110         


Leu Ser Ala Pro Val Ser Gln Lys Met His Arg Lys Ile Gln Ser Ser 
        115                 120                 125             


Leu Ser Val Asn Ser Asp Ile Ser Lys Lys Ser Lys Val Asn Ala Val 
    130                 135                 140                 


Phe Ser Gln Lys Thr Gly Ser Ser Pro Glu Val Cys 
145                 150                 155     


<210>  8478
<211>  135
<212>  PRT
<213>  Homo Sapiens

<400>  8478

Met Gln Asp Gln Ser Ile Trp Gly Asn Pro Ser Asp Gly Glu Leu Ile 
1               5                   10                  15      


Arg Thr Gln Pro Gln Arg Leu Pro Gln Leu Gln Thr Ser Ala Gln Val 
            20                  25                  30          


Pro Ser Gly Glu Glu Ile Gly Lys Ile Lys Asn Gly His Thr Gly Leu 
        35                  40                  45              


Ser Asn Gly Asn Gly Ile His His Gly Ala Lys His Gly Ser Ala Asp 
    50                  55                  60                  


Asn Arg Lys Leu Ser Ala Pro Val Ser Gln Lys Met His Arg Lys Ile 
65                  70                  75                  80  


Gln Ser Ser Leu Ser Val Asn Ser Asp Ile Ser Lys Lys Ser Lys Val 
                85                  90                  95      


Asn Ala Val Phe Ser Gln Lys Thr Gly Ser Ser Pro Glu Asp Cys Cys 
            100                 105                 110         


Val His Cys Ile Leu Ala Cys Leu Phe Cys Glu Phe Leu Thr Leu Cys 
        115                 120                 125             


Asn Ile Val Leu Gly Gln Ala 
    130                 135 


<210>  8479
<211>  246
<212>  PRT
<213>  Homo Sapiens

<400>  8479

Met Ser Gly Ala Gly Glu Ala Leu Ala Pro Gly Pro Val Gly Pro Gln 
1               5                   10                  15      


Arg Val Ala Glu Ala Gly Gly Gly Gln Leu Gly Ser Thr Ala Gln Gly 
            20                  25                  30          


Lys Cys Asp Lys Asp Asn Thr Glu Lys Asp Ile Thr Gln Ala Thr Asn 
        35                  40                  45              


Ser His Phe Thr His Gly Glu Met Gln Asp Gln Ser Ile Trp Gly Asn 
    50                  55                  60                  


Pro Ser Asp Gly Glu Leu Ile Arg Thr Gln Pro Gln Arg Leu Pro Gln 
65                  70                  75                  80  


Leu Gln Thr Ser Ala Gln Val Pro Ser Gly Glu Glu Ile Gly Lys Ile 
                85                  90                  95      


Lys Asn Gly His Thr Gly Leu Ser Asn Gly Asn Gly Ile His His Gly 
            100                 105                 110         


Ala Lys His Gly Ser Ala Asp Asn Arg Lys Leu Ser Ala Pro Val Ser 
        115                 120                 125             


Gln Lys Met His Arg Lys Ile Gln Ser Ser Leu Ser Val Asn Ser Asp 
    130                 135                 140                 


Ile Ser Lys Lys Ser Lys Val Asn Ala Val Phe Ser Gln Lys Thr Gly 
145                 150                 155                 160 


Ser Ser Pro Glu Asp Cys Cys Val His Cys Ile Leu Ala Cys Leu Phe 
                165                 170                 175     


Cys Glu Phe Leu Thr Leu Cys Asn Ile Val Leu Gly Gln Ala Ser Cys 
            180                 185                 190         


Gly Ile Cys Thr Ser Glu Ala Cys Cys Cys Cys Cys Gly Asp Glu Met 
        195                 200                 205             


Gly Asp Asp Cys Asn Cys Pro Cys Asp Met Asp Cys Gly Ile Met Asp 
    210                 215                 220                 


Ala Cys Cys Glu Ser Ser Asp Cys Leu Glu Ile Cys Met Glu Cys Cys 
225                 230                 235                 240 


Gly Ile Cys Phe Pro Ser 
                245     


<210>  8480
<211>  43
<212>  PRT
<213>  Homo Sapiens

<400>  8480

Met Ser Gly Ala Gly Glu Ala Leu Ala Pro Gly Pro Val Gly Pro Gln 
1               5                   10                  15      


Arg Val Ala Glu Ala Gly Gly Gly Gln Leu Gly Ser Thr Ala Gln Gly 
            20                  25                  30          


Leu Phe Ser Arg Ser Arg Thr Ala Ala Ala Leu 
        35                  40              


<210>  8481
<211>  43
<212>  PRT
<213>  Homo Sapiens

<400>  8481

Met Ser Gly Ala Gly Glu Ala Leu Ala Pro Gly Pro Val Gly Pro Gln 
1               5                   10                  15      


Arg Val Ala Glu Ala Gly Gly Gly Gln Leu Gly Ser Thr Ala Gln Gly 
            20                  25                  30          


Leu Phe Ser Arg Ser Arg Thr Ala Ala Ala Leu 
        35                  40              


<210>  8482
<211>  156
<212>  PRT
<213>  Homo Sapiens

<400>  8482

Pro Gln Arg Val Ala Glu Ala Gly Gly Gly Gln Leu Gly Ser Thr Ala 
1               5                   10                  15      


Gln Gly Lys Cys Asp Lys Asp Asn Thr Glu Lys Asp Ile Thr Gln Ala 
            20                  25                  30          


Thr Asn Ser His Phe Thr His Gly Glu Met Gln Asp Gln Ser Ile Trp 
        35                  40                  45              


Gly Asn Pro Ser Asp Gly Glu Leu Ile Arg Thr Gln Pro Gln Arg Leu 
    50                  55                  60                  


Pro Gln Leu Gln Thr Ser Ala Gln Val Pro Ser Gly Glu Glu Ile Gly 
65                  70                  75                  80  


Lys Ile Lys Asn Gly His Thr Gly Leu Ser Asn Gly Asn Gly Ile His 
                85                  90                  95      


His Gly Ala Lys His Gly Ser Ala Asp Asn Arg Lys Leu Ser Ala Pro 
            100                 105                 110         


Val Ser Gln Lys Met His Arg Lys Ile Gln Ser Ser Leu Ser Val Asn 
        115                 120                 125             


Ser Asp Ile Ser Lys Lys Ser Lys Val Asn Ala Val Phe Ser Gln Lys 
    130                 135                 140                 


Thr Gly Ser Ser Pro Glu Asp Lys Gln Glu Phe Trp 
145                 150                 155     


<210>  8483
<211>  355
<212>  PRT
<213>  Homo Sapiens

<400>  8483

Val Arg Gly Val Arg Ala Ala Thr Ala Ala Ala Val Ala Ala Thr Ala 
1               5                   10                  15      


Ala Ser Gly Leu Ser Arg Arg Glu Ala Gly Gly Arg Ala Gly Ala Ala 
            20                  25                  30          


Ala Ala Val Val Arg Pro Pro Gly Arg Lys Cys Gly Arg Cys Arg Arg 
        35                  40                  45              


Leu Ala Asn Phe Pro Gly Arg Lys Arg Arg Arg Arg Arg Arg Lys Gly 
    50                  55                  60                  


Leu Gly Ala Thr Thr Gly Gly Cys Gly Glu Ala Val Ser Ser Leu His 
65                  70                  75                  80  


Pro Ala Pro His Ser Pro Ser Ser Val Arg Pro Ala Gly Arg Arg Ala 
                85                  90                  95      


Arg Arg Gln Arg Arg Gly Ala Gly Ser Ala Glu Arg Pro Met Ser Gly 
            100                 105                 110         


Ala Gly Glu Ala Leu Ala Pro Gly Pro Val Gly Pro Gln Arg Val Ala 
        115                 120                 125             


Glu Ala Gly Gly Gly Gln Leu Gly Ser Thr Ala Gln Gly Lys Cys Asp 
    130                 135                 140                 


Lys Asp Asn Thr Glu Lys Asp Ile Thr Gln Ala Thr Asn Ser His Phe 
145                 150                 155                 160 


Thr His Gly Glu Met Gln Asp Gln Ser Ile Trp Gly Asn Pro Ser Asp 
                165                 170                 175     


Gly Glu Leu Ile Arg Thr Gln Pro Gln Arg Leu Pro Gln Leu Gln Thr 
            180                 185                 190         


Ser Ala Gln Val Pro Ser Gly Glu Glu Ile Gly Lys Ile Lys Asn Gly 
        195                 200                 205             


His Thr Gly Leu Ser Asn Gly Asn Gly Ile His His Gly Ala Lys His 
    210                 215                 220                 


Gly Ser Ala Asp Asn Arg Lys Leu Ser Ala Pro Val Ser Gln Lys Met 
225                 230                 235                 240 


His Arg Lys Ile Gln Ser Ser Leu Ser Val Asn Ser Asp Ile Ser Lys 
                245                 250                 255     


Lys Ser Lys Val Asn Ala Val Phe Ser Gln Lys Thr Gly Ser Ser Pro 
            260                 265                 270         


Glu Asp Cys Cys Val His Cys Ile Leu Ala Cys Leu Phe Cys Glu Phe 
        275                 280                 285             


Leu Thr Leu Cys Asn Ile Val Leu Gly Gln Ala Ser Cys Gly Ile Cys 
    290                 295                 300                 


Thr Ser Glu Ala Cys Cys Cys Cys Cys Gly Asp Glu Met Gly Asp Asp 
305                 310                 315                 320 


Cys Asn Cys Pro Cys Asp Met Asp Cys Gly Ile Met Asp Ala Cys Cys 
                325                 330                 335     


Glu Ser Ser Asp Cys Leu Glu Ile Cys Met Glu Cys Cys Gly Ile Cys 
            340                 345                 350         


Phe Pro Ser 
        355 


<210>  8484
<211>  355
<212>  PRT
<213>  Homo Sapiens

<400>  8484

Val Arg Gly Val Arg Ala Ala Thr Ala Ala Ala Val Ala Ala Thr Ala 
1               5                   10                  15      


Ala Ser Gly Leu Ser Arg Arg Glu Ala Gly Gly Arg Ala Gly Ala Ala 
            20                  25                  30          


Ala Ala Val Val Arg Pro Pro Gly Arg Lys Cys Gly Arg Cys Arg Arg 
        35                  40                  45              


Leu Ala Asn Phe Pro Gly Arg Lys Arg Arg Arg Arg Arg Arg Lys Gly 
    50                  55                  60                  


Leu Gly Ala Thr Thr Gly Gly Cys Gly Glu Ala Val Ser Ser Leu His 
65                  70                  75                  80  


Pro Ala Pro His Ser Pro Ser Ser Val Arg Pro Ala Gly Arg Arg Ala 
                85                  90                  95      


Arg Arg Gln Arg Arg Gly Ala Gly Ser Ala Glu Arg Pro Met Ser Gly 
            100                 105                 110         


Ala Gly Glu Ala Leu Ala Pro Gly Pro Val Gly Pro Gln Arg Val Ala 
        115                 120                 125             


Glu Ala Gly Gly Gly Gln Leu Gly Ser Thr Ala Gln Gly Lys Cys Asp 
    130                 135                 140                 


Lys Asp Asn Thr Glu Lys Asp Ile Thr Gln Ala Thr Asn Ser His Phe 
145                 150                 155                 160 


Thr His Gly Glu Met Gln Asp Gln Ser Ile Trp Gly Asn Pro Ser Asp 
                165                 170                 175     


Gly Glu Leu Ile Arg Thr Gln Pro Gln Arg Leu Pro Gln Leu Gln Thr 
            180                 185                 190         


Ser Ala Gln Val Pro Ser Gly Glu Glu Ile Gly Lys Ile Lys Asn Gly 
        195                 200                 205             


His Thr Gly Leu Ser Asn Gly Asn Gly Ile His His Gly Ala Lys His 
    210                 215                 220                 


Gly Ser Ala Asp Asn Arg Lys Leu Ser Ala Pro Val Ser Gln Lys Met 
225                 230                 235                 240 


His Arg Lys Ile Gln Ser Ser Leu Ser Val Asn Ser Asp Ile Ser Lys 
                245                 250                 255     


Lys Ser Lys Val Asn Ala Val Phe Ser Gln Lys Thr Gly Ser Ser Pro 
            260                 265                 270         


Glu Asp Cys Cys Val His Cys Ile Leu Ala Cys Leu Phe Cys Glu Phe 
        275                 280                 285             


Leu Thr Leu Cys Asn Ile Val Leu Gly Gln Ala Ser Cys Gly Ile Cys 
    290                 295                 300                 


Thr Ser Glu Ala Cys Cys Cys Cys Cys Gly Asp Glu Met Gly Asp Asp 
305                 310                 315                 320 


Cys Asn Cys Pro Cys Asp Met Asp Cys Gly Ile Met Asp Ala Cys Cys 
                325                 330                 335     


Glu Ser Ser Asp Cys Leu Glu Ile Cys Met Glu Cys Cys Gly Ile Cys 
            340                 345                 350         


Phe Pro Ser 
        355 


<210>  8485
<211>  973
<212>  PRT
<213>  Homo Sapiens

<400>  8485

Met Glu Val Thr Cys Leu Leu Leu Leu Ala Leu Ile Pro Phe His Cys 
1               5                   10                  15      


Arg Gly Gln Gly Val Tyr Ala Pro Ala Gln Ala Gln Ile Val His Ala 
            20                  25                  30          


Gly Gln Ala Cys Val Val Lys Glu Asp Asn Ile Ser Glu Arg Val Tyr 
        35                  40                  45              


Thr Ile Arg Glu Gly Asp Thr Leu Met Leu Gln Cys Leu Val Thr Gly 
    50                  55                  60                  


His Pro Arg Pro Gln Val Arg Trp Thr Lys Thr Ala Gly Ser Ala Ser 
65                  70                  75                  80  


Asp Lys Phe Gln Glu Thr Ser Val Phe Asn Glu Thr Leu Arg Ile Glu 
                85                  90                  95      


Arg Ile Ala Arg Thr Gln Gly Gly Arg Tyr Tyr Cys Lys Ala Glu Asn 
            100                 105                 110         


Gly Val Gly Val Pro Ala Ile Lys Ser Ile Arg Val Asp Val Gln Tyr 
        115                 120                 125             


Leu Asp Glu Pro Met Leu Thr Val His Gln Thr Val Ser Asp Val Arg 
    130                 135                 140                 


Gly Asn Phe Tyr Gln Glu Lys Thr Val Phe Leu Arg Cys Thr Val Asn 
145                 150                 155                 160 


Ser Asn Pro Pro Ala Arg Phe Ile Trp Lys Arg Gly Ser Asp Thr Leu 
                165                 170                 175     


Ser His Ser Gln Asp Asn Gly Val Asp Ile Tyr Glu Pro Leu Tyr Thr 
            180                 185                 190         


Gln Gly Glu Thr Lys Val Leu Lys Leu Lys Asn Leu Arg Pro Gln Asp 
        195                 200                 205             


Tyr Ala Ser Tyr Thr Cys Gln Val Ser Val Arg Asn Val Cys Gly Ile 
    210                 215                 220                 


Pro Asp Lys Ala Ile Thr Phe Arg Leu Thr Asn Thr Thr Ala Pro Pro 
225                 230                 235                 240 


Ala Leu Lys Leu Ser Val Asn Glu Thr Leu Val Val Asn Pro Gly Glu 
                245                 250                 255     


Asn Val Thr Val Gln Cys Leu Leu Thr Gly Gly Asp Pro Leu Pro Gln 
            260                 265                 270         


Leu Gln Trp Ser His Gly Pro Gly Pro Leu Pro Leu Gly Ala Leu Ala 
        275                 280                 285             


Gln Gly Gly Thr Leu Ser Ile Pro Ser Val Gln Ala Arg Asp Ser Gly 
    290                 295                 300                 


Tyr Tyr Asn Cys Thr Ala Thr Asn Asn Val Gly Asn Pro Ala Lys Lys 
305                 310                 315                 320 


Thr Val Asn Leu Leu Val Arg Ser Met Lys Asn Ala Thr Phe Gln Ile 
                325                 330                 335     


Thr Pro Asp Val Ile Lys Glu Ser Glu Asn Ile Gln Leu Gly Gln Asp 
            340                 345                 350         


Leu Lys Leu Ser Cys His Val Asp Ala Val Pro Gln Glu Lys Val Thr 
        355                 360                 365             


Tyr Gln Trp Phe Lys Asn Gly Lys Pro Ala Arg Met Ser Lys Arg Leu 
    370                 375                 380                 


Leu Val Thr Arg Asn Asp Pro Glu Leu Pro Ala Val Thr Ser Ser Leu 
385                 390                 395                 400 


Glu Leu Ile Asp Leu His Phe Ser Asp Tyr Gly Thr Tyr Leu Cys Met 
                405                 410                 415     


Ala Ser Phe Pro Gly Ala Pro Val Pro Asp Leu Ser Val Glu Val Asn 
            420                 425                 430         


Ile Ser Ser Glu Thr Val Pro Pro Thr Ile Ser Val Pro Lys Gly Arg 
        435                 440                 445             


Ala Val Val Thr Val Arg Glu Gly Ser Pro Ala Glu Leu Gln Cys Glu 
    450                 455                 460                 


Val Arg Gly Lys Pro Arg Pro Pro Val Leu Trp Ser Arg Val Asp Lys 
465                 470                 475                 480 


Glu Ala Ala Leu Leu Pro Ser Gly Leu Pro Leu Glu Glu Thr Pro Asp 
                485                 490                 495     


Gly Lys Leu Arg Leu Glu Arg Val Ser Arg Asp Met Ser Gly Thr Tyr 
            500                 505                 510         


Arg Cys Gln Thr Ala Arg Tyr Asn Gly Phe Asn Val Arg Pro Arg Glu 
        515                 520                 525             


Ala Gln Val Gln Leu Asn Val Gln Phe Pro Pro Glu Val Glu Pro Ser 
    530                 535                 540                 


Ser Gln Asp Val Arg Gln Ala Leu Gly Arg Pro Val Leu Leu Arg Cys 
545                 550                 555                 560 


Ser Leu Leu Arg Gly Ser Pro Gln Arg Ile Ala Ser Ala Val Trp Arg 
                565                 570                 575     


Phe Lys Gly Gln Leu Leu Pro Pro Pro Pro Val Val Pro Ala Ala Ala 
            580                 585                 590         


Glu Ala Pro Asp His Ala Glu Leu Arg Leu Asp Ala Val Thr Arg Asp 
        595                 600                 605             


Ser Ser Gly Ser Tyr Glu Cys Ser Val Ser Asn Asp Val Gly Ser Ala 
    610                 615                 620                 


Ala Cys Leu Phe Gln Val Ser Ala Lys Ala Tyr Ser Pro Glu Phe Tyr 
625                 630                 635                 640 


Phe Asp Thr Pro Asn Pro Thr Arg Ser His Lys Leu Ser Lys Asn Tyr 
                645                 650                 655     


Ser Tyr Val Leu Gln Trp Thr Gln Arg Glu Pro Asp Ala Val Asp Pro 
            660                 665                 670         


Val Leu Asn Tyr Arg Leu Ser Ile Arg Gln Leu Asn Gln His Asn Ala 
        675                 680                 685             


Val Val Lys Ala Ile Pro Val Arg Arg Val Glu Lys Gly Gln Leu Leu 
    690                 695                 700                 


Glu Tyr Ile Leu Thr Asp Leu Arg Val Pro His Ser Tyr Glu Val Arg 
705                 710                 715                 720 


Leu Thr Pro Tyr Thr Thr Phe Gly Ala Gly Asp Met Ala Ser Arg Ile 
                725                 730                 735     


Ile His Tyr Thr Glu Pro Ile Asn Ser Pro Asn Leu Ser Asp Asn Thr 
            740                 745                 750         


Cys His Phe Glu Asp Glu Lys Ile Cys Gly Tyr Thr Gln Asp Leu Thr 
        755                 760                 765             


Asp Asn Phe Asp Trp Thr Arg Gln Asn Ala Leu Thr Gln Asn Pro Lys 
    770                 775                 780                 


Arg Ser Pro Asn Thr Gly Pro Pro Thr Asp Ile Ser Gly Thr Pro Glu 
785                 790                 795                 800 


Gly Tyr Tyr Met Phe Ile Glu Thr Ser Arg Pro Arg Glu Leu Gly Asp 
                805                 810                 815     


Arg Ala Arg Leu Val Ser Pro Leu Tyr Asn Ala Ser Ala Lys Phe Tyr 
            820                 825                 830         


Cys Val Ser Phe Phe Tyr His Met Tyr Gly Lys His Ile Gly Ser Leu 
        835                 840                 845             


Asn Leu Leu Val Arg Ser Arg Asn Lys Gly Ala Leu Asp Thr His Ala 
    850                 855                 860                 


Trp Ser Leu Ser Gly Asn Lys Gly Asn Val Trp Gln Gln Ala His Val 
865                 870                 875                 880 


Pro Ile Ser Pro Ser Gly Pro Phe Gln Ile Ile Phe Glu Gly Val Arg 
                885                 890                 895     


Gly Pro Gly Tyr Leu Gly Asp Ile Ala Ile Asp Asp Val Thr Leu Lys 
            900                 905                 910         


Lys Gly Glu Cys Pro Arg Lys Gln Thr Asp Pro Asn Lys Gly Ala Arg 
        915                 920                 925             


Arg Glu Gly Gly Gly Gly Ala Glu Ser Gly Gly Ser Cys Ala Trp Arg 
    930                 935                 940                 


Gly Phe Leu Ser Val Glu Gly Gly Cys Leu Gly Leu Asn Arg Gly Ser 
945                 950                 955                 960 


Glu Cys Leu Ser Asp Gly Asn His Val Ala Leu Thr Val 
                965                 970             


<210>  8486
<211>  955
<212>  PRT
<213>  Homo Sapiens

<400>  8486

Met Glu Val Thr Cys Leu Leu Leu Leu Ala Leu Ile Pro Phe His Cys 
1               5                   10                  15      


Arg Gly Gln Gly Val Tyr Ala Pro Ala Gln Ala Gln Ile Val His Ala 
            20                  25                  30          


Gly Gln Ala Cys Val Val Lys Glu Asp Asn Ile Ser Glu Arg Val Tyr 
        35                  40                  45              


Thr Ile Arg Glu Gly Asp Thr Leu Met Leu Gln Cys Leu Val Thr Gly 
    50                  55                  60                  


His Pro Arg Pro Gln Val Arg Trp Thr Lys Thr Ala Gly Ser Ala Ser 
65                  70                  75                  80  


Asp Lys Phe Gln Glu Thr Ser Val Phe Asn Glu Thr Leu Arg Ile Glu 
                85                  90                  95      


Arg Ile Ala Arg Thr Gln Gly Gly Arg Tyr Tyr Cys Lys Ala Glu Asn 
            100                 105                 110         


Gly Val Gly Val Pro Ala Ile Lys Ser Ile Arg Val Asp Val Gln Tyr 
        115                 120                 125             


Leu Asp Glu Pro Met Leu Thr Val His Gln Thr Val Ser Asp Val Arg 
    130                 135                 140                 


Gly Asn Phe Tyr Gln Glu Lys Thr Val Phe Leu Arg Cys Thr Val Asn 
145                 150                 155                 160 


Ser Asn Pro Pro Ala Arg Phe Ile Trp Lys Arg Gly Ser Asp Thr Leu 
                165                 170                 175     


Ser His Ser Gln Asp Asn Gly Val Asp Ile Tyr Glu Pro Leu Tyr Thr 
            180                 185                 190         


Gln Gly Glu Thr Lys Val Leu Lys Leu Lys Asn Leu Arg Pro Gln Asp 
        195                 200                 205             


Tyr Ala Ser Tyr Thr Cys Gln Val Ser Val Arg Asn Val Cys Gly Ile 
    210                 215                 220                 


Pro Asp Lys Ala Ile Thr Phe Arg Leu Thr Asn Thr Thr Ala Pro Pro 
225                 230                 235                 240 


Ala Leu Lys Leu Ser Val Asn Glu Thr Leu Val Val Asn Pro Gly Glu 
                245                 250                 255     


Asn Val Thr Val Gln Cys Leu Leu Thr Gly Gly Asp Pro Leu Pro Gln 
            260                 265                 270         


Leu Gln Trp Ser His Gly Pro Gly Pro Leu Pro Leu Gly Ala Leu Ala 
        275                 280                 285             


Gln Gly Gly Thr Leu Ser Ile Pro Ser Val Gln Ala Arg Asp Ser Gly 
    290                 295                 300                 


Tyr Tyr Asn Cys Thr Ala Thr Asn Asn Val Gly Asn Pro Ala Lys Lys 
305                 310                 315                 320 


Thr Val Asn Leu Leu Val Arg Ser Met Lys Asn Ala Thr Phe Gln Ile 
                325                 330                 335     


Thr Pro Asp Val Ile Lys Glu Ser Glu Asn Ile Gln Leu Gly Gln Asp 
            340                 345                 350         


Leu Lys Leu Ser Cys His Val Asp Ala Val Pro Gln Glu Lys Val Thr 
        355                 360                 365             


Tyr Gln Trp Phe Lys Asn Gly Lys Pro Ala Arg Met Ser Lys Arg Leu 
    370                 375                 380                 


Leu Val Thr Arg Asn Asp Pro Glu Leu Pro Ala Val Thr Ser Ser Leu 
385                 390                 395                 400 


Glu Leu Ile Asp Leu His Phe Ser Asp Tyr Gly Thr Tyr Leu Cys Met 
                405                 410                 415     


Ala Ser Phe Pro Gly Ala Pro Val Pro Asp Leu Ser Val Glu Val Asn 
            420                 425                 430         


Ile Ser Ser Glu Thr Val Pro Pro Thr Ile Ser Val Pro Lys Gly Arg 
        435                 440                 445             


Ala Val Val Thr Val Arg Glu Gly Ser Pro Ala Glu Leu Gln Cys Glu 
    450                 455                 460                 


Val Arg Gly Lys Pro Arg Pro Pro Val Leu Trp Ser Arg Val Asp Lys 
465                 470                 475                 480 


Glu Ala Ala Leu Leu Pro Ser Gly Leu Pro Leu Glu Glu Thr Pro Asp 
                485                 490                 495     


Gly Lys Leu Arg Leu Glu Arg Val Ser Arg Asp Met Ser Gly Thr Tyr 
            500                 505                 510         


Arg Cys Gln Thr Ala Arg Tyr Asn Gly Phe Asn Val Arg Pro Arg Glu 
        515                 520                 525             


Ala Gln Val Gln Leu Asn Val Gln Phe Pro Pro Glu Val Glu Pro Ser 
    530                 535                 540                 


Ser Gln Asp Val Arg Gln Ala Leu Gly Arg Pro Val Leu Leu Arg Cys 
545                 550                 555                 560 


Ser Leu Leu Arg Gly Ser Pro Gln Arg Ile Ala Ser Ala Val Trp Arg 
                565                 570                 575     


Phe Lys Gly Gln Leu Leu Pro Pro Pro Pro Val Val Pro Ala Ala Ala 
            580                 585                 590         


Glu Ala Pro Asp His Ala Glu Leu Arg Leu Asp Ala Val Thr Arg Asp 
        595                 600                 605             


Ser Ser Gly Ser Tyr Glu Cys Ser Val Ser Asn Asp Val Gly Ser Ala 
    610                 615                 620                 


Ala Cys Leu Phe Gln Val Ser Ala Lys Ala Tyr Ser Pro Glu Phe Tyr 
625                 630                 635                 640 


Phe Asp Thr Pro Asn Pro Thr Arg Ser His Lys Leu Ser Lys Asn Tyr 
                645                 650                 655     


Ser Tyr Val Leu Gln Trp Thr Gln Arg Glu Pro Asp Ala Val Asp Pro 
            660                 665                 670         


Val Leu Asn Tyr Arg Leu Ser Ile Arg Gln Leu Asn Gln His Asn Ala 
        675                 680                 685             


Val Val Lys Ala Ile Pro Val Arg Arg Val Glu Lys Gly Gln Leu Leu 
    690                 695                 700                 


Glu Tyr Ile Leu Thr Asp Leu Arg Val Pro His Ser Tyr Glu Val Arg 
705                 710                 715                 720 


Leu Thr Pro Tyr Thr Thr Phe Gly Ala Gly Asp Met Ala Ser Arg Ile 
                725                 730                 735     


Ile His Tyr Thr Glu Pro Ile Asn Ser Pro Asn Leu Ser Asp Asn Thr 
            740                 745                 750         


Cys His Phe Glu Asp Glu Lys Ile Cys Gly Tyr Thr Gln Asp Leu Thr 
        755                 760                 765             


Asp Asn Phe Asp Trp Thr Arg Gln Asn Ala Leu Thr Gln Asn Pro Lys 
    770                 775                 780                 


Arg Ser Pro Asn Thr Gly Pro Pro Thr Asp Ile Ser Gly Thr Pro Glu 
785                 790                 795                 800 


Gly Tyr Tyr Met Phe Ile Glu Thr Ser Arg Pro Arg Glu Leu Gly Asp 
                805                 810                 815     


Arg Ala Arg Leu Val Ser Pro Leu Tyr Asn Ala Ser Ala Lys Phe Tyr 
            820                 825                 830         


Cys Val Ser Phe Phe Tyr His Met Tyr Gly Lys His Ile Gly Ser Leu 
        835                 840                 845             


Asn Leu Leu Val Arg Ser Arg Asn Lys Gly Ala Leu Asp Thr His Ala 
    850                 855                 860                 


Trp Ser Leu Ser Gly Asn Lys Gly Asn Val Trp Gln Gln Ala His Val 
865                 870                 875                 880 


Pro Ile Ser Pro Ser Gly Pro Phe Gln Ile Ile Phe Glu Gly Val Arg 
                885                 890                 895     


Gly Pro Gly Tyr Leu Gly Asp Ile Ala Ile Asp Asp Val Thr Leu Lys 
            900                 905                 910         


Lys Gly Glu Cys Pro Arg Lys Gln Thr Asp Pro Asn Lys Val Val Val 
        915                 920                 925             


Met Pro Gly Ser Gly Ala Pro Cys Gln Ser Ser Pro Gln Leu Trp Gly 
    930                 935                 940                 


Pro Met Ala Ile Phe Leu Leu Ala Leu Gln Arg 
945                 950                 955 


<210>  8487
<211>  77
<212>  PRT
<213>  Homo Sapiens

<400>  8487

Met Leu Gln Cys Leu Val Thr Gly His Pro Arg Pro Gln Val Arg Trp 
1               5                   10                  15      


Thr Lys Thr Ala Gly Ser Ala Ser Asp Lys Phe Gln Glu Thr Ser Val 
            20                  25                  30          


Phe Asn Glu Thr Leu Arg Ile Glu Arg Ile Ala Arg Thr Gln Gly Gly 
        35                  40                  45              


Arg Tyr Tyr Cys Lys Ala Glu Asn Gly Val Gly Val Pro Ala Ile Lys 
    50                  55                  60                  


Ser Ile Arg Val Asp Val Gln Tyr Leu Asp Glu Pro Met 
65                  70                  75          


<210>  8488
<211>  129
<212>  PRT
<213>  Homo Sapiens

<400>  8488

Met Leu Gln Cys Leu Val Thr Gly His Pro Arg Pro Gln Val Arg Trp 
1               5                   10                  15      


Thr Lys Thr Ala Gly Ser Ala Ser Asp Lys Phe Gln Glu Thr Ser Val 
            20                  25                  30          


Phe Asn Glu Thr Leu Arg Ile Glu Arg Ile Ala Arg Thr Gln Gly Gly 
        35                  40                  45              


Arg Tyr Tyr Cys Lys Ala Glu Asn Gly Val Gly Val Pro Ala Ile Lys 
    50                  55                  60                  


Ser Ile Arg Val Asp Val Gln Tyr Leu Asp Glu Pro Met Leu Thr Val 
65                  70                  75                  80  


His Gln Thr Val Ser Asp Val Arg Gly Asn Phe Tyr Gln Glu Lys Thr 
                85                  90                  95      


Val Phe Leu Arg Cys Thr Val Asn Ser Asn Pro Pro Ala Arg Phe Ile 
            100                 105                 110         


Trp Lys Arg Gly Ser Asp Thr Leu Ser His Ser Gln Asp Asn Gly Val 
        115                 120                 125             


Asp 
    


<210>  8489
<211>  87
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8489

Xaa His Lys Leu Ser Lys Asn Tyr Ser Tyr Val Leu Gln Trp Thr Gln 
1               5                   10                  15      


Arg Glu Pro Asp Ala Val Asp Pro Val Leu Asn Tyr Arg Leu Ser Ile 
            20                  25                  30          


Arg Gln Leu Asn Gln His Asn Ala Val Val Lys Ala Ile Pro Val Arg 
        35                  40                  45              


Arg Val Glu Lys Gly Gln Leu Leu Glu Tyr Ile Leu Thr Asp Leu Arg 
    50                  55                  60                  


Val Pro His Ser Tyr Glu Thr Thr Pro Ala Thr Leu Arg Met Arg Arg 
65                  70                  75                  80  


Ser Val Ala Ile Pro Arg Thr 
                85          


<210>  8490
<211>  160
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8490

Xaa Asn Gln His Asn Ala Val Val Lys Ala Ile Pro Val Arg Arg Val 
1               5                   10                  15      


Glu Lys Gly Gln Leu Leu Glu Tyr Ile Leu Thr Asp Leu Arg Val Pro 
            20                  25                  30          


His Ser Tyr Glu Val Arg Leu Thr Pro Tyr Thr Thr Phe Gly Ala Gly 
        35                  40                  45              


Asp Met Ala Ser Arg Ile Ile His Tyr Thr Glu His Asn Thr Cys His 
    50                  55                  60                  


Phe Glu Asp Glu Lys Ile Cys Gly Tyr Thr Gln Asp Leu Thr Asp Asn 
65                  70                  75                  80  


Phe Asp Trp Thr Arg Gln Asn Ala Leu Thr Gln Asn Pro Lys Arg Ser 
                85                  90                  95      


Pro Asn Thr Gly Pro Pro Thr Asp Ile Ser Gly Thr Pro Glu Gly Tyr 
            100                 105                 110         


Tyr Met Phe Ile Glu Thr Ser Arg Pro Arg Glu Leu Gly Asp Arg Ala 
        115                 120                 125             


Arg Leu Val Ser Pro Leu Tyr Asn Ala Ser Ala Lys Phe Tyr Cys Val 
    130                 135                 140                 


Ser Phe Phe Tyr His Met Tyr Gly Lys His Ile Gly Ser Leu Asn Leu 
145                 150                 155                 160 


<210>  8491
<211>  87
<212>  PRT
<213>  Homo Sapiens

<400>  8491

Met Gln His Arg Gly Phe Leu Leu Leu Thr Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Leu Thr Ser Ala Val Ala Lys Lys Lys Ala Asp Cys Lys Tyr Lys Phe 
            20                  25                  30          


Glu Asn Trp Gly Ala Cys Asp Gly Gly Thr Gly Thr Lys Val Arg Gln 
        35                  40                  45              


Gly Thr Leu Lys Lys Ala Arg Tyr Asn Ala Gln Cys Gln Glu Thr Ile 
    50                  55                  60                  


Arg Val Thr Lys Pro Cys Thr Pro Lys Thr Lys Ala Lys Ala Lys Ala 
65                  70                  75                  80  


Lys Lys Gly Lys Gly Lys Asp 
                85          


<210>  8492
<211>  49
<212>  PRT
<213>  Homo Sapiens

<400>  8492

Met Gln His Arg Gly Phe Leu Leu Leu Thr Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Leu Thr Ser Ala Val Ala Lys Lys Lys Asp Lys Val Lys Lys Gly Gly 
            20                  25                  30          


Pro Gly Ser Glu Cys Ala Glu Trp Ala Trp Gly Pro Cys Thr Pro Ser 
        35                  40                  45              


Ser 
    


<210>  8493
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  8493

Met Gln His Arg Gly Phe Leu Leu Leu Thr Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Leu Thr Ser Ala Val Ala Lys Lys Lys Asp Lys Val Lys Lys Gly Gly 
            20                  25                  30          


Pro Gly Ser Glu Cys Ala Glu Trp Ala Trp Gly Pro Cys Thr Pro Ser 
        35                  40                  45              


Ser Lys Asp Cys Gly Val Gly Phe Arg Glu Gly Thr Cys Gly Ala Gln 
    50                  55                  60                  


Thr Gln Arg Ile Arg Cys Arg Val Pro Cys Asn Trp Lys Lys Glu Phe 
65                  70                  75                  80  


Gly Ala Asp Cys Lys Tyr Lys Phe Glu Asn Trp Gly Ala Cys Asp Gly 
                85                  90                  95      


Gly Thr Gly Thr Lys Val Arg Gln Gly Thr Leu Lys Lys Ala Arg Tyr 
            100                 105                 110         


Asn Ala Gln Cys Gln Glu Thr Ile Arg Val Thr Lys Pro Cys Thr Pro 
        115                 120                 125             


Lys Thr Lys 
    130     


<210>  8494
<211>  143
<212>  PRT
<213>  Homo Sapiens

<400>  8494

Met Gln His Arg Gly Phe Leu Leu Leu Thr Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Leu Thr Ser Ala Val Ala Lys Lys Lys Asp Lys Val Lys Lys Gly Gly 
            20                  25                  30          


Pro Gly Ser Glu Cys Ala Glu Trp Ala Trp Gly Pro Cys Thr Pro Ser 
        35                  40                  45              


Ser Lys Asp Cys Gly Val Gly Phe Arg Glu Gly Thr Cys Gly Ala Gln 
    50                  55                  60                  


Thr Gln Arg Ile Arg Cys Arg Val Pro Cys Asn Trp Lys Lys Glu Phe 
65                  70                  75                  80  


Gly Ala Asp Cys Lys Tyr Lys Phe Glu Asn Trp Gly Ala Cys Asp Gly 
                85                  90                  95      


Gly Thr Gly Thr Lys Val Arg Gln Gly Thr Leu Lys Lys Ala Arg Tyr 
            100                 105                 110         


Asn Ala Gln Cys Gln Glu Thr Ile Arg Val Thr Lys Pro Cys Thr Pro 
        115                 120                 125             


Lys Thr Lys Ala Lys Ala Lys Ala Lys Lys Gly Lys Gly Lys Asp 
    130                 135                 140             


<210>  8495
<211>  143
<212>  PRT
<213>  Homo Sapiens

<400>  8495

Met Gln His Arg Gly Phe Leu Leu Leu Thr Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Leu Thr Ser Ala Val Ala Lys Lys Lys Asp Lys Val Lys Lys Gly Gly 
            20                  25                  30          


Pro Gly Ser Glu Cys Ala Glu Trp Ala Trp Gly Pro Cys Thr Pro Ser 
        35                  40                  45              


Ser Lys Asp Cys Gly Val Gly Phe Arg Glu Gly Thr Cys Gly Ala Gln 
    50                  55                  60                  


Thr Gln Arg Ile Arg Cys Arg Val Pro Cys Asn Trp Lys Lys Glu Phe 
65                  70                  75                  80  


Gly Ala Asp Cys Lys Tyr Lys Phe Glu Asn Trp Gly Ala Cys Asp Gly 
                85                  90                  95      


Gly Thr Gly Thr Lys Val Arg Gln Gly Thr Leu Lys Lys Ala Arg Tyr 
            100                 105                 110         


Asn Ala Gln Cys Gln Glu Thr Ile Arg Val Thr Lys Pro Cys Thr Pro 
        115                 120                 125             


Lys Thr Lys Ala Lys Ala Lys Ala Lys Lys Gly Lys Gly Lys Asp 
    130                 135                 140             


<210>  8496
<211>  143
<212>  PRT
<213>  Homo Sapiens

<400>  8496

Met Gln His Arg Gly Phe Leu Leu Leu Thr Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Leu Thr Ser Ala Val Ala Lys Lys Lys Asp Lys Val Lys Lys Gly Gly 
            20                  25                  30          


Pro Gly Ser Glu Cys Ala Glu Trp Ala Trp Gly Pro Cys Thr Pro Ser 
        35                  40                  45              


Ser Lys Asp Cys Gly Val Gly Phe Arg Glu Gly Thr Cys Gly Ala Gln 
    50                  55                  60                  


Thr Gln Arg Ile Arg Cys Arg Val Pro Cys Asn Trp Lys Lys Glu Phe 
65                  70                  75                  80  


Gly Ala Asp Cys Lys Tyr Lys Phe Glu Asn Trp Gly Ala Cys Asp Gly 
                85                  90                  95      


Gly Thr Gly Thr Lys Val Arg Gln Gly Thr Leu Lys Lys Ala Arg Tyr 
            100                 105                 110         


Asn Ala Gln Cys Gln Glu Thr Ile Arg Val Thr Lys Pro Cys Thr Pro 
        115                 120                 125             


Lys Thr Lys Ala Lys Ala Lys Ala Lys Lys Gly Lys Gly Lys Asp 
    130                 135                 140             


<210>  8497
<211>  143
<212>  PRT
<213>  Homo Sapiens

<400>  8497

Met Gln His Arg Gly Phe Leu Leu Leu Thr Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Leu Thr Ser Ala Val Ala Lys Lys Lys Asp Lys Val Lys Lys Gly Gly 
            20                  25                  30          


Pro Gly Ser Glu Cys Ala Glu Trp Ala Trp Gly Pro Cys Thr Pro Ser 
        35                  40                  45              


Ser Lys Asp Cys Gly Val Gly Phe Arg Glu Gly Thr Cys Gly Ala Gln 
    50                  55                  60                  


Thr Gln Arg Ile Arg Cys Arg Val Pro Cys Asn Trp Lys Lys Glu Phe 
65                  70                  75                  80  


Gly Ala Asp Cys Lys Tyr Lys Phe Glu Asn Trp Gly Ala Cys Asp Gly 
                85                  90                  95      


Gly Thr Gly Thr Lys Val Arg Gln Gly Thr Leu Lys Lys Ala Arg Tyr 
            100                 105                 110         


Asn Ala Gln Cys Gln Glu Thr Ile Arg Val Thr Lys Pro Cys Thr Pro 
        115                 120                 125             


Lys Thr Lys Ala Lys Ala Lys Ala Lys Lys Gly Lys Gly Lys Asp 
    130                 135                 140             


<210>  8498
<211>  143
<212>  PRT
<213>  Homo Sapiens

<400>  8498

Met Gln His Arg Gly Phe Leu Leu Leu Thr Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Leu Thr Ser Ala Val Ala Lys Lys Lys Asp Lys Val Lys Lys Gly Gly 
            20                  25                  30          


Pro Gly Ser Glu Cys Ala Glu Trp Ala Trp Gly Pro Cys Thr Pro Ser 
        35                  40                  45              


Ser Lys Asp Cys Gly Val Gly Phe Arg Glu Gly Thr Cys Gly Ala Gln 
    50                  55                  60                  


Thr Gln Arg Ile Arg Cys Arg Val Pro Cys Asn Trp Lys Lys Glu Phe 
65                  70                  75                  80  


Gly Ala Asp Cys Lys Tyr Lys Phe Glu Asn Trp Gly Ala Cys Asp Gly 
                85                  90                  95      


Gly Thr Gly Thr Lys Val Arg Gln Gly Thr Leu Lys Lys Ala Arg Tyr 
            100                 105                 110         


Asn Ala Gln Cys Gln Glu Thr Ile Arg Val Thr Lys Pro Cys Thr Pro 
        115                 120                 125             


Lys Thr Lys Ala Lys Ala Lys Ala Lys Lys Gly Lys Gly Lys Asp 
    130                 135                 140             


<210>  8499
<211>  156
<212>  PRT
<213>  Homo Sapiens

<400>  8499

Met Gln His Arg Gly Phe Leu Leu Leu Thr Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Leu Thr Ser Ala Val Ala Lys Lys Lys Asp Lys Val Lys Lys Gly Gly 
            20                  25                  30          


Pro Gly Ser Glu Cys Ala Glu Trp Ala Trp Gly Pro Cys Thr Pro Ser 
        35                  40                  45              


Ser Lys Asp Cys Gly Val Gly Phe Arg Glu Gly Thr Cys Gly Ala Gln 
    50                  55                  60                  


Thr Gln Arg Ile Arg Cys Arg Val Pro Cys Asn Trp Lys Lys Glu Phe 
65                  70                  75                  80  


Gly Ala Asp Cys Lys Tyr Lys Phe Glu Asn Trp Gly Ala Cys Asp Gly 
                85                  90                  95      


Gly Thr Gly Thr Lys Val Arg Gln Gly Thr Leu Lys Lys Ala Arg Tyr 
            100                 105                 110         


Asn Ala Gln Cys Gln Glu Thr Ile Arg Val Thr Lys Pro Cys Thr Pro 
        115                 120                 125             


Lys Thr Lys Ala Lys Ala Lys Gly Gln Arg Lys Glu Lys Gly Val Gly 
    130                 135                 140                 


Leu Ser Arg Gly Ala Ala Pro Pro Pro Pro Arg Leu 
145                 150                 155     


<210>  8500
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  8500

Met Gln His Arg Gly Phe Leu Leu Leu Thr Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Leu Thr Ser Ala Val Ala Lys Lys Lys Glu Glu Gly Ala Leu Gln Cys 
            20                  25                  30          


Ser Val Pro Gly Asp His Pro Arg His Gln Ala Leu His Pro Gln Asp 
        35                  40                  45              


Gln Ser Lys Gly Gln Ser Gln Glu Arg Glu Gly Lys Gly Leu Asp Ala 
    50                  55                  60                  


Lys Pro Gly Cys Gln Gly Ala Pro Gly Val Thr Trp Gly Leu Ala His 
65                  70                  75                  80  


Ala Leu Pro Leu Pro Gly Pro Arg Cys Asp Pro Pro Val Pro Ser Val 
                85                  90                  95      


Cys Ser Leu Ala Leu Ile Asn His Ala Leu Pro Cys Pro Ser His Ser 
            100                 105                 110         


Pro Ala Pro Pro Leu Ser Ala Gln Ser Gly Glu Gly Gln Gly Ile Leu 
        115                 120                 125             


Gly Ser Leu Ser Leu Pro Gln Ser Asn Val Ser Pro Arg Ala Arg Phe 
    130                 135                 140                 


Cys Ser Ser Pro Gln Phe His Tyr 
145                 150         


<210>  8501
<211>  123
<212>  PRT
<213>  Homo Sapiens

<400>  8501

Met Gly Val Thr Cys Val Ser Gln Met Pro Val Ala Glu Gly Lys Ser 
1               5                   10                  15      


Val Gln Gln Thr Val Glu Leu Leu Thr Arg Lys Leu Glu Met Leu Gly 
            20                  25                  30          


Ala Glu Lys Gln Gly Thr Phe Cys Val Asp Cys Glu Thr Tyr His Thr 
        35                  40                  45              


Ala Ala Ser Thr Leu Gly Ser Gln Gly Gln Thr Gly Lys Leu Met Tyr 
    50                  55                  60                  


Val Met His Asn Ser Glu Tyr Pro Leu Ser Cys Phe Ala Leu Phe Glu 
65                  70                  75                  80  


Asn Gly Pro Cys Leu Ile Ala Asp Thr Asn Phe Asp Val Leu Met Val 
                85                  90                  95      


Lys Leu Lys Gly Phe Phe Gln Ser Ala Lys Ala Ser Lys Ile Glu Thr 
            100                 105                 110         


Arg Gly Thr Arg Trp Ser Met Ala Pro Val Trp 
        115                 120             


<210>  8502
<211>  212
<212>  PRT
<213>  Homo Sapiens

<400>  8502

Met Gly Val Thr Cys Val Ser Gln Met Pro Val Ala Glu Gly Lys Ser 
1               5                   10                  15      


Val Gln Gln Thr Val Glu Leu Leu Thr Arg Lys Leu Glu Met Leu Gly 
            20                  25                  30          


Ala Glu Lys Gln Gly Thr Phe Cys Val Asp Cys Glu Thr Tyr His Thr 
        35                  40                  45              


Ala Ala Ser Thr Leu Gly Ser Gln Gly Gln Thr Gly Lys Leu Met Tyr 
    50                  55                  60                  


Val Met His Asn Ser Glu Tyr Pro Leu Ser Cys Phe Ala Leu Phe Glu 
65                  70                  75                  80  


Asn Gly Pro Cys Leu Ile Ala Asp Thr Asn Phe Asp Val Leu Met Val 
                85                  90                  95      


Lys Leu Lys Gly Phe Phe Gln Ser Ala Lys Ala Ser Lys Ile Glu Thr 
            100                 105                 110         


Arg Gly Thr Arg Tyr Gln Tyr Cys Asp Phe Leu Val Lys Val Gly Thr 
        115                 120                 125             


Val Thr Met Gly Pro Ser Ala Arg Gly Ile Ser Val Glu Val Glu Tyr 
    130                 135                 140                 


Gly Pro Cys Val Val Ala Ser Asp Cys Trp Ser Leu Leu Leu Glu Phe 
145                 150                 155                 160 


Leu Gln Ser Phe Leu Gly Ser His Thr Pro Gly Ala Pro Ala Val Phe 
                165                 170                 175     


Gly Asn Arg His Asp Ala Val Tyr Gly Pro Ala Asp Thr Met Val Gln 
            180                 185                 190         


Tyr Met Glu Leu Phe Asn Lys Ile Arg Lys Gln Gln Gln Val Pro Val 
        195                 200                 205             


Ala Gly Ile Arg 
    210         


<210>  8503
<211>  145
<212>  PRT
<213>  Homo Sapiens

<400>  8503

Met Gly Val Thr Cys Val Ser Gln Met Pro Val Ala Glu Gly Lys Ser 
1               5                   10                  15      


Val Gln Gln Thr Val Glu Leu Leu Thr Arg Lys Leu Glu Met Leu Gly 
            20                  25                  30          


Ala Glu Lys Gln Gly Thr Phe Cys Val Asp Cys Glu Thr Tyr His Thr 
        35                  40                  45              


Ala Ala Ser Thr Leu Gly Ser Gln Gly Gln Thr Gly Lys Leu Met Tyr 
    50                  55                  60                  


Val Met His Asn Ser Glu Tyr Pro Leu Ser Cys Phe Ala Leu Phe Glu 
65                  70                  75                  80  


Asn Gly Pro Cys Leu Ile Ala Asp Thr Asn Phe Asp Val Leu Met Val 
                85                  90                  95      


Lys Leu Lys Gly Phe Phe Gln Ser Ala Lys Ala Ser Lys Ile Glu Thr 
            100                 105                 110         


Arg Gly Thr Arg Tyr Gln Tyr Cys Asp Phe Leu Val Lys Val Gly Thr 
        115                 120                 125             


Val Thr Met Gly Pro Ser Ala Arg Gly Ile Ser Val Glu Val Arg Pro 
    130                 135                 140                 


Trp 
145 


<210>  8504
<211>  61
<212>  PRT
<213>  Homo Sapiens

<400>  8504

Met Met Glu Met Phe Ser Asn Asn Ser Val Gln Tyr Thr Ser Pro Ser 
1               5                   10                  15      


His Leu Trp Leu Trp Ala Thr Val Leu Asn Ser Ser Ser Ser Gln Ser 
            20                  25                  30          


Cys Val Ser Gln Met Pro Val Ala Glu Gly Lys Ser Val Gln Gln Thr 
        35                  40                  45              


Val Glu Leu Leu Thr Arg Lys Leu Glu Met Leu Gly Ala 
    50                  55                  60      


<210>  8505
<211>  140
<212>  PRT
<213>  Homo Sapiens

<400>  8505

Met Pro Val Ala Glu Gly Lys Ser Val Gln Gln Thr Val Glu Leu Leu 
1               5                   10                  15      


Thr Arg Lys Leu Glu Met Leu Gly Ala Glu Lys Gln Gly Thr Phe Cys 
            20                  25                  30          


Val Asp Cys Glu Thr Tyr His Thr Ala Ala Ser Thr Leu Gly Ser Gln 
        35                  40                  45              


Gly Gln Thr Gly Lys Leu Met Tyr Val Met His Asn Ser Glu Tyr Pro 
    50                  55                  60                  


Leu Ser Cys Phe Ala Leu Phe Glu Asn Gly Pro Cys Leu Ile Ala Asp 
65                  70                  75                  80  


Thr Asn Phe Asp Val Leu Met Val Lys Leu Lys Gly Phe Phe Gln Ser 
                85                  90                  95      


Ala Lys Ala Ser Lys Ile Glu Thr Arg Gly Thr Arg Tyr Gln Tyr Cys 
            100                 105                 110         


Asp Phe Leu Val Lys Val Gly Thr Val Thr Met Gly Pro Ser Ala Arg 
        115                 120                 125             


Gly Ile Ser Val Glu Val Glu Tyr Gly Pro Cys Val 
    130                 135                 140 


<210>  8506
<211>  1140
<212>  PRT
<213>  Homo Sapiens

<400>  8506

Met Val Ile Ser Leu Asn Ser Cys Leu Ser Phe Ile Cys Leu Leu Leu 
1               5                   10                  15      


Cys His Trp Ile Gly Thr Ala Ser Pro Leu Asn Leu Glu Asp Pro Asn 
            20                  25                  30          


Val Cys Ser His Trp Glu Ser Tyr Ser Val Thr Val Gln Glu Ser Tyr 
        35                  40                  45              


Pro His Pro Phe Asp Gln Ile Tyr Tyr Thr Ser Cys Thr Asp Ile Leu 
    50                  55                  60                  


Asn Trp Phe Lys Cys Thr Arg His Arg Val Ser Tyr Arg Thr Ala Tyr 
65                  70                  75                  80  


Arg His Gly Glu Lys Thr Met Tyr Arg Arg Lys Ser Gln Cys Cys Pro 
                85                  90                  95      


Gly Phe Tyr Glu Ser Gly Glu Met Cys Val Pro His Cys Ala Asp Lys 
            100                 105                 110         


Cys Val His Gly Arg Cys Ile Ala Pro Asn Thr Cys Gln Cys Glu Pro 
        115                 120                 125             


Gly Trp Gly Gly Thr Asn Cys Ser Ser Ala Cys Asp Gly Asp His Trp 
    130                 135                 140                 


Gly Pro His Cys Thr Ser Arg Cys Gln Cys Lys Asn Gly Ala Leu Cys 
145                 150                 155                 160 


Asn Pro Ile Thr Gly Ala Cys His Cys Ala Ala Gly Phe Arg Gly Trp 
                165                 170                 175     


Arg Cys Glu Asp Arg Cys Glu Gln Gly Thr Tyr Gly Asn Asp Cys His 
            180                 185                 190         


Gln Arg Cys Gln Cys Gln Asn Gly Ala Thr Cys Asp His Val Thr Gly 
        195                 200                 205             


Glu Cys Arg Cys Pro Pro Gly Tyr Thr Gly Ala Phe Cys Glu Asp Leu 
    210                 215                 220                 


Cys Pro Pro Gly Lys His Gly Pro Gln Cys Glu Gln Arg Cys Pro Cys 
225                 230                 235                 240 


Gln Asn Gly Gly Val Cys His His Val Thr Gly Glu Cys Ser Cys Pro 
                245                 250                 255     


Ser Gly Trp Met Gly Thr Val Cys Gly Gln Pro Cys Pro Glu Gly Arg 
            260                 265                 270         


Phe Gly Lys Asn Cys Ser Gln Glu Cys Gln Cys His Asn Gly Gly Thr 
        275                 280                 285             


Cys Asp Ala Ala Thr Gly Gln Cys His Cys Ser Pro Gly Tyr Thr Gly 
    290                 295                 300                 


Glu Arg Cys Gln Asp Glu Cys Pro Val Gly Thr Tyr Gly Val Leu Cys 
305                 310                 315                 320 


Ala Glu Thr Cys Gln Cys Val Asn Gly Gly Lys Cys Tyr His Val Ser 
                325                 330                 335     


Gly Ala Cys Leu Cys Glu Ala Gly Phe Ala Gly Glu Arg Cys Glu Ala 
            340                 345                 350         


Arg Leu Cys Pro Glu Gly Leu Tyr Gly Ile Lys Cys Asp Lys Arg Cys 
        355                 360                 365             


Pro Cys His Leu Glu Asn Thr His Ser Cys His Pro Met Ser Gly Glu 
    370                 375                 380                 


Cys Ala Cys Lys Pro Gly Trp Ser Gly Leu Tyr Cys Asn Glu Thr Cys 
385                 390                 395                 400 


Ser Pro Gly Phe Tyr Gly Glu Ala Cys Gln Gln Ile Cys Ser Cys Gln 
                405                 410                 415     


Asn Gly Ala Asp Cys Asp Ser Val Thr Gly Lys Cys Thr Cys Ala Pro 
            420                 425                 430         


Gly Phe Lys Gly Ile Asp Cys Ser Thr Pro Cys Pro Leu Gly Thr Tyr 
        435                 440                 445             


Gly Ile Asn Cys Ser Ser Arg Cys Gly Cys Lys Asn Asp Ala Val Cys 
    450                 455                 460                 


Ser Pro Val Asp Gly Ser Cys Thr Cys Lys Ala Gly Trp His Gly Val 
465                 470                 475                 480 


Asp Cys Ser Ile Arg Cys Pro Ser Gly Thr Trp Gly Phe Gly Cys Asn 
                485                 490                 495     


Leu Thr Cys Gln Cys Leu Asn Gly Gly Ala Cys Asn Thr Leu Asp Gly 
            500                 505                 510         


Thr Cys Thr Cys Ala Pro Gly Trp Arg Gly Glu Lys Cys Glu Leu Pro 
        515                 520                 525             


Cys Gln Asp Gly Thr Tyr Gly Leu Asn Cys Ala Glu Arg Cys Asp Cys 
    530                 535                 540                 


Ser His Ala Asp Gly Cys His Pro Thr Thr Gly His Cys Arg Cys Leu 
545                 550                 555                 560 


Pro Gly Trp Ser Gly Val His Cys Asp Ser Val Cys Ala Glu Gly Arg 
                565                 570                 575     


Trp Gly Pro Asn Cys Ser Leu Pro Cys Tyr Cys Lys Asn Gly Ala Ser 
            580                 585                 590         


Cys Ser Pro Asp Asp Gly Ile Cys Glu Cys Ala Pro Gly Phe Arg Gly 
        595                 600                 605             


Thr Thr Cys Gln Arg Ile Cys Ser Pro Gly Phe Tyr Gly His Arg Cys 
    610                 615                 620                 


Ser Gln Thr Cys Pro Gln Cys Val His Ser Ser Gly Pro Cys His His 
625                 630                 635                 640 


Ile Thr Gly Leu Cys Asp Cys Leu Pro Gly Phe Thr Gly Ala Leu Cys 
                645                 650                 655     


Asn Glu Val Cys Pro Ser Gly Arg Phe Gly Lys Asn Cys Ala Gly Ile 
            660                 665                 670         


Cys Thr Cys Thr Asn Asn Gly Thr Cys Asn Pro Ile Asp Arg Ser Cys 
        675                 680                 685             


Gln Cys Tyr Pro Gly Trp Ile Gly Ser Asp Cys Ser Gln Pro Cys Pro 
    690                 695                 700                 


Pro Ala His Trp Gly Pro Asn Cys Ile His Thr Cys Asn Cys His Asn 
705                 710                 715                 720 


Gly Ala Phe Cys Ser Ala Tyr Asp Gly Glu Cys Lys Cys Thr Pro Gly 
                725                 730                 735     


Trp Thr Gly Leu Tyr Cys Thr Gln Arg Cys Pro Leu Gly Phe Tyr Gly 
            740                 745                 750         


Lys Asp Cys Ala Leu Ile Cys Gln Cys Gln Asn Gly Ala Asp Cys Asp 
        755                 760                 765             


His Ile Ser Gly Gln Cys Thr Cys Arg Thr Gly Phe Met Gly Arg His 
    770                 775                 780                 


Cys Glu Gln Lys Cys Pro Ser Gly Thr Tyr Gly Tyr Gly Cys Arg Gln 
785                 790                 795                 800 


Ile Cys Asp Cys Leu Asn Asn Ser Thr Cys Asp His Ile Thr Gly Thr 
                805                 810                 815     


Cys Tyr Cys Ser Pro Gly Trp Lys Gly Ala Arg Cys Asp Gln Ala Gly 
            820                 825                 830         


Val Ile Ile Val Gly Asn Leu Asn Ser Leu Ser Arg Thr Ser Thr Ala 
        835                 840                 845             


Leu Pro Ala Asp Ser Tyr Gln Ile Gly Ala Ile Ala Gly Ile Ile Ile 
    850                 855                 860                 


Leu Val Leu Val Val Leu Phe Leu Leu Ala Leu Phe Ile Ile Tyr Arg 
865                 870                 875                 880 


His Lys Gln Lys Gly Lys Glu Ser Ser Met Pro Ala Val Thr Tyr Thr 
                885                 890                 895     


Pro Ala Met Arg Val Val Asn Ala Asp Tyr Thr Ile Ser Gly Thr Leu 
            900                 905                 910         


Pro His Ser Asn Gly Gly Asn Ala Asn Ser His Tyr Phe Thr Asn Pro 
        915                 920                 925             


Ser Tyr His Thr Leu Thr Gln Cys Ala Thr Ser Pro His Val Asn Asn 
    930                 935                 940                 


Arg Asp Arg Met Thr Val Thr Lys Ser Lys Asn Asn Gln Leu Phe Val 
945                 950                 955                 960 


Asn Leu Lys Asn Val Asn Pro Gly Lys Arg Gly Pro Val Gly Asp Cys 
                965                 970                 975     


Thr Gly Thr Leu Pro Ala Asp Trp Lys His Gly Gly Tyr Leu Asn Glu 
            980                 985                 990         


Leu Gly Ala Phe Gly Leu Asp Arg  Ser Tyr Met Gly Lys  Ser Leu Lys 
        995                 1000                 1005             


Asp Leu  Gly Lys Asn Ser Glu  Tyr Asn Ser Ser Asn  Cys Ser Leu 
    1010                 1015                 1020             


Ser Ser  Ser Glu Asn Pro Tyr  Ala Thr Ile Lys Asp  Pro Pro Val 
    1025                 1030                 1035             


Leu Ile  Pro Lys Ser Ser Glu  Cys Gly Tyr Val Glu  Met Lys Ser 
    1040                 1045                 1050             


Pro Ala  Arg Arg Asp Ser Pro  Tyr Ala Glu Ile Asn  Asn Ser Thr 
    1055                 1060                 1065             


Ser Ala  Asn Arg Asn Val Tyr  Glu Val Glu Pro Thr  Val Ser Val 
    1070                 1075                 1080             


Val Gln  Gly Val Phe Ser Asn  Asn Gly Arg Leu Ser  Gln Asp Pro 
    1085                 1090                 1095             


Tyr Asp  Leu Pro Lys Asn Ser  His Ile Pro Cys His  Tyr Asp Leu 
    1100                 1105                 1110             


Leu Pro  Val Arg Asp Ser Ser  Ser Ser Pro Lys Gln  Glu Asp Ser 
    1115                 1120                 1125             


Gly Gly  Ser Ser Ser Asn Ser  Ser Ser Ser Ser Glu  
    1130                 1135                 1140 


<210>  8507
<211>  567
<212>  PRT
<213>  Homo Sapiens

<400>  8507

Met Val Ile Ser Leu Asn Ser Cys Leu Ser Phe Ile Cys Leu Leu Leu 
1               5                   10                  15      


Cys His Trp Ile Gly Thr Ala Ser Pro Leu Asn Leu Glu Asp Pro Asn 
            20                  25                  30          


Val Cys Ser His Trp Glu Ser Tyr Ser Val Thr Val Gln Glu Ser Tyr 
        35                  40                  45              


Pro His Pro Phe Asp Gln Ile Tyr Tyr Thr Ser Cys Thr Asp Ile Leu 
    50                  55                  60                  


Asn Trp Phe Lys Cys Thr Arg His Arg Val Ser Tyr Arg Thr Ala Tyr 
65                  70                  75                  80  


Arg His Gly Glu Lys Thr Met Tyr Arg Arg Lys Ser Gln Cys Cys Pro 
                85                  90                  95      


Gly Phe Tyr Glu Ser Gly Glu Met Cys Val Pro His Cys Ala Asp Lys 
            100                 105                 110         


Cys Val His Gly Arg Cys Ile Ala Pro Asn Thr Cys Gln Cys Glu Pro 
        115                 120                 125             


Gly Trp Gly Gly Thr Asn Cys Ser Ser Ala Cys Asp Gly Asp His Trp 
    130                 135                 140                 


Gly Pro His Cys Thr Ser Arg Cys Gln Cys Lys Asn Gly Ala Leu Cys 
145                 150                 155                 160 


Asn Pro Ile Thr Gly Ala Cys His Cys Ala Ala Gly Phe Arg Gly Trp 
                165                 170                 175     


Arg Cys Glu Asp Arg Cys Glu Gln Gly Thr Tyr Gly Asn Asp Cys His 
            180                 185                 190         


Gln Arg Cys Gln Cys Gln Asn Gly Ala Thr Cys Asp His Val Thr Gly 
        195                 200                 205             


Glu Cys Arg Cys Pro Pro Gly Tyr Thr Gly Ala Phe Cys Glu Asp Leu 
    210                 215                 220                 


Cys Pro Pro Gly Lys His Gly Pro Gln Cys Glu Gln Arg Cys Pro Cys 
225                 230                 235                 240 


Gln Asn Gly Gly Val Cys His His Val Thr Gly Glu Cys Ser Cys Pro 
                245                 250                 255     


Ser Gly Trp Met Gly Thr Val Cys Gly Gln Pro Cys Pro Glu Gly Arg 
            260                 265                 270         


Phe Gly Lys Asn Cys Ser Gln Glu Cys Gln Cys His Asn Gly Gly Thr 
        275                 280                 285             


Cys Asp Ala Ala Thr Gly Gln Cys His Cys Ser Pro Gly Tyr Thr Gly 
    290                 295                 300                 


Glu Arg Cys Gln Asp Glu Cys Pro Val Gly Thr Tyr Gly Val Leu Cys 
305                 310                 315                 320 


Ala Glu Thr Cys Gln Cys Val Asn Gly Gly Lys Cys Tyr His Val Ser 
                325                 330                 335     


Gly Ala Cys Leu Cys Glu Ala Gly Phe Ala Gly Glu Arg Cys Glu Ala 
            340                 345                 350         


Arg Leu Cys Pro Glu Gly Leu Tyr Gly Ile Lys Cys Asp Lys Arg Cys 
        355                 360                 365             


Pro Cys His Leu Glu Asn Thr His Ser Cys His Pro Met Ser Gly Glu 
    370                 375                 380                 


Cys Ala Cys Lys Pro Gly Trp Ser Gly Leu Tyr Cys Asn Glu Thr Cys 
385                 390                 395                 400 


Ser Pro Gly Phe Tyr Gly Glu Ala Cys Gln Gln Ile Cys Ser Cys Gln 
                405                 410                 415     


Asn Gly Ala Asp Cys Asp Ser Val Thr Gly Lys Cys Thr Cys Ala Pro 
            420                 425                 430         


Gly Phe Lys Gly Ile Asp Cys Ser Thr Pro Cys Pro Leu Gly Thr Tyr 
        435                 440                 445             


Gly Ile Asn Cys Ser Ser Arg Cys Gly Cys Lys Asn Asp Ala Val Cys 
    450                 455                 460                 


Ser Pro Val Asp Gly Ser Cys Thr Cys Lys Ala Gly Trp His Gly Val 
465                 470                 475                 480 


Asp Cys Ser Ile Arg Cys Pro Ser Gly Thr Trp Gly Phe Gly Cys Asn 
                485                 490                 495     


Leu Thr Cys Gln Cys Leu Asn Gly Gly Ala Cys Asn Thr Leu Asp Gly 
            500                 505                 510         


Thr Cys Thr Cys Ala Pro Gly Trp Arg Gly Glu Lys Cys Glu Leu Pro 
        515                 520                 525             


Cys Gln Asp Gly Thr Tyr Gly Leu Asn Cys Ala Glu Arg Cys Asp Cys 
    530                 535                 540                 


Ser His Ala Asp Gly Cys His Pro Thr Thr Gly His Cys Arg Cys Leu 
545                 550                 555                 560 


Pro Gly Trp Ser Gly Leu Phe 
                565         


<210>  8508
<211>  1140
<212>  PRT
<213>  Homo Sapiens

<400>  8508

Met Val Ile Ser Leu Asn Ser Cys Leu Ser Phe Ile Cys Leu Leu Leu 
1               5                   10                  15      


Cys His Trp Ile Gly Thr Ala Ser Pro Leu Asn Leu Glu Asp Pro Asn 
            20                  25                  30          


Val Cys Ser His Trp Glu Ser Tyr Ser Val Thr Val Gln Glu Ser Tyr 
        35                  40                  45              


Pro His Pro Phe Asp Gln Ile Tyr Tyr Thr Ser Cys Thr Asp Ile Leu 
    50                  55                  60                  


Asn Trp Phe Lys Cys Thr Arg His Arg Val Ser Tyr Arg Thr Ala Tyr 
65                  70                  75                  80  


Arg His Gly Glu Lys Thr Met Tyr Arg Arg Lys Ser Gln Cys Cys Pro 
                85                  90                  95      


Gly Phe Tyr Glu Ser Gly Glu Met Cys Val Pro His Cys Ala Asp Lys 
            100                 105                 110         


Cys Val His Gly Arg Cys Ile Ala Pro Asn Thr Cys Gln Cys Glu Pro 
        115                 120                 125             


Gly Trp Gly Gly Thr Asn Cys Ser Ser Ala Cys Asp Gly Asp His Trp 
    130                 135                 140                 


Gly Pro His Cys Thr Ser Arg Cys Gln Cys Lys Asn Gly Ala Leu Cys 
145                 150                 155                 160 


Asn Pro Ile Thr Gly Ala Cys His Cys Ala Ala Gly Phe Arg Gly Trp 
                165                 170                 175     


Arg Cys Glu Asp Arg Cys Glu Gln Gly Thr Tyr Gly Asn Asp Cys His 
            180                 185                 190         


Gln Arg Cys Gln Cys Gln Asn Gly Ala Thr Cys Asp His Val Thr Gly 
        195                 200                 205             


Glu Cys Arg Cys Pro Pro Gly Tyr Thr Gly Ala Phe Cys Glu Asp Leu 
    210                 215                 220                 


Cys Pro Pro Gly Lys His Gly Pro Gln Cys Glu Gln Arg Cys Pro Cys 
225                 230                 235                 240 


Gln Asn Gly Gly Val Cys His His Val Thr Gly Glu Cys Ser Cys Pro 
                245                 250                 255     


Ser Gly Trp Met Gly Thr Val Cys Gly Gln Pro Cys Pro Glu Gly Arg 
            260                 265                 270         


Phe Gly Lys Asn Cys Ser Gln Glu Cys Gln Cys His Asn Gly Gly Thr 
        275                 280                 285             


Cys Asp Ala Ala Thr Gly Gln Cys His Cys Ser Pro Gly Tyr Thr Gly 
    290                 295                 300                 


Glu Arg Cys Gln Asp Glu Cys Pro Val Gly Thr Tyr Gly Val Leu Cys 
305                 310                 315                 320 


Ala Glu Thr Cys Gln Cys Val Asn Gly Gly Lys Cys Tyr His Val Ser 
                325                 330                 335     


Gly Ala Cys Leu Cys Glu Ala Gly Phe Ala Gly Glu Arg Cys Glu Ala 
            340                 345                 350         


Arg Leu Cys Pro Glu Gly Leu Tyr Gly Ile Lys Cys Asp Lys Arg Cys 
        355                 360                 365             


Pro Cys His Leu Glu Asn Thr His Ser Cys His Pro Met Ser Gly Glu 
    370                 375                 380                 


Cys Ala Cys Lys Pro Gly Trp Ser Gly Leu Tyr Cys Asn Glu Thr Cys 
385                 390                 395                 400 


Ser Pro Gly Phe Tyr Gly Glu Ala Cys Gln Gln Ile Cys Ser Cys Gln 
                405                 410                 415     


Asn Gly Ala Asp Cys Asp Ser Val Thr Gly Lys Cys Thr Cys Ala Pro 
            420                 425                 430         


Gly Phe Lys Gly Ile Asp Cys Ser Thr Pro Cys Pro Leu Gly Thr Tyr 
        435                 440                 445             


Gly Ile Asn Cys Ser Ser Arg Cys Gly Cys Lys Asn Asp Ala Val Cys 
    450                 455                 460                 


Ser Pro Val Asp Gly Ser Cys Thr Cys Lys Ala Gly Trp His Gly Val 
465                 470                 475                 480 


Asp Cys Ser Ile Arg Cys Pro Ser Gly Thr Trp Gly Phe Gly Cys Asn 
                485                 490                 495     


Leu Thr Cys Gln Cys Leu Asn Gly Gly Ala Cys Asn Thr Leu Asp Gly 
            500                 505                 510         


Thr Cys Thr Cys Ala Pro Gly Trp Arg Gly Glu Lys Cys Glu Leu Pro 
        515                 520                 525             


Cys Gln Asp Gly Thr Tyr Gly Leu Asn Cys Ala Glu Arg Cys Asp Cys 
    530                 535                 540                 


Ser His Ala Asp Gly Cys His Pro Thr Thr Gly His Cys Arg Cys Leu 
545                 550                 555                 560 


Pro Gly Trp Ser Gly Val His Cys Asp Ser Val Cys Ala Glu Gly Arg 
                565                 570                 575     


Trp Gly Pro Asn Cys Ser Leu Pro Cys Tyr Cys Lys Asn Gly Ala Ser 
            580                 585                 590         


Cys Ser Pro Asp Asp Gly Ile Cys Glu Cys Ala Pro Gly Phe Arg Gly 
        595                 600                 605             


Thr Thr Cys Gln Arg Ile Cys Ser Pro Gly Phe Tyr Gly His Arg Cys 
    610                 615                 620                 


Ser Gln Thr Cys Pro Gln Cys Val His Ser Ser Gly Pro Cys His His 
625                 630                 635                 640 


Ile Thr Gly Leu Cys Asp Cys Leu Pro Gly Phe Thr Gly Ala Leu Cys 
                645                 650                 655     


Asn Glu Val Cys Pro Ser Gly Arg Phe Gly Lys Asn Cys Ala Gly Ile 
            660                 665                 670         


Cys Thr Cys Thr Asn Asn Gly Thr Cys Asn Pro Ile Asp Arg Ser Cys 
        675                 680                 685             


Gln Cys Tyr Pro Gly Trp Ile Gly Ser Asp Cys Ser Gln Pro Cys Pro 
    690                 695                 700                 


Pro Ala His Trp Gly Pro Asn Cys Ile His Thr Cys Asn Cys His Asn 
705                 710                 715                 720 


Gly Ala Phe Cys Ser Ala Tyr Asp Gly Glu Cys Lys Cys Thr Pro Gly 
                725                 730                 735     


Trp Thr Gly Leu Tyr Cys Thr Gln Arg Cys Pro Leu Gly Phe Tyr Gly 
            740                 745                 750         


Lys Asp Cys Ala Leu Ile Cys Gln Cys Gln Asn Gly Ala Asp Cys Asp 
        755                 760                 765             


His Ile Ser Gly Gln Cys Thr Cys Arg Thr Gly Phe Met Gly Arg His 
    770                 775                 780                 


Cys Glu Gln Lys Cys Pro Ser Gly Thr Tyr Gly Tyr Gly Cys Arg Gln 
785                 790                 795                 800 


Ile Cys Asp Cys Leu Asn Asn Ser Thr Cys Asp His Ile Thr Gly Thr 
                805                 810                 815     


Cys Tyr Cys Ser Pro Gly Trp Lys Gly Ala Arg Cys Asp Gln Ala Gly 
            820                 825                 830         


Val Ile Ile Val Gly Asn Leu Asn Ser Leu Ser Arg Thr Ser Thr Ala 
        835                 840                 845             


Leu Pro Ala Asp Ser Tyr Gln Ile Gly Ala Ile Ala Gly Ile Ile Ile 
    850                 855                 860                 


Leu Val Leu Val Val Leu Phe Leu Leu Ala Leu Phe Ile Ile Tyr Arg 
865                 870                 875                 880 


His Lys Gln Lys Gly Lys Glu Ser Ser Met Pro Ala Val Thr Tyr Thr 
                885                 890                 895     


Pro Ala Met Arg Val Val Asn Ala Asp Tyr Thr Ile Ser Gly Thr Leu 
            900                 905                 910         


Pro His Ser Asn Gly Gly Asn Ala Asn Ser His Tyr Phe Thr Asn Pro 
        915                 920                 925             


Ser Tyr His Thr Leu Thr Gln Cys Ala Thr Ser Pro His Val Asn Asn 
    930                 935                 940                 


Arg Asp Arg Met Thr Val Thr Lys Ser Lys Asn Asn Gln Leu Phe Val 
945                 950                 955                 960 


Asn Leu Lys Asn Val Asn Pro Gly Lys Arg Gly Pro Val Gly Asp Cys 
                965                 970                 975     


Thr Gly Thr Leu Pro Ala Asp Trp Lys His Gly Gly Tyr Leu Asn Glu 
            980                 985                 990         


Leu Gly Ala Phe Gly Leu Asp Arg  Ser Tyr Met Gly Lys  Ser Leu Lys 
        995                 1000                 1005             


Asp Leu  Gly Lys Asn Ser Glu  Tyr Asn Ser Ser Asn  Cys Ser Leu 
    1010                 1015                 1020             


Ser Ser  Ser Glu Asn Pro Tyr  Ala Thr Ile Lys Asp  Pro Pro Val 
    1025                 1030                 1035             


Leu Ile  Pro Lys Ser Ser Glu  Cys Gly Tyr Val Glu  Met Lys Ser 
    1040                 1045                 1050             


Pro Ala  Arg Arg Asp Ser Pro  Tyr Ala Glu Ile Asn  Asn Ser Thr 
    1055                 1060                 1065             


Ser Ala  Asn Arg Asn Val Tyr  Glu Val Glu Pro Thr  Val Ser Val 
    1070                 1075                 1080             


Val Gln  Gly Val Phe Ser Asn  Asn Gly Arg Leu Ser  Gln Asp Pro 
    1085                 1090                 1095             


Tyr Asp  Leu Pro Lys Asn Ser  His Ile Pro Cys His  Tyr Asp Leu 
    1100                 1105                 1110             


Leu Pro  Val Arg Asp Ser Ser  Ser Ser Pro Lys Gln  Glu Asp Ser 
    1115                 1120                 1125             


Gly Gly  Ser Ser Ser Asn Ser  Ser Ser Ser Ser Glu  
    1130                 1135                 1140 


<210>  8509
<211>  567
<212>  PRT
<213>  Homo Sapiens

<400>  8509

Met Val Ile Ser Leu Asn Ser Cys Leu Ser Phe Ile Cys Leu Leu Leu 
1               5                   10                  15      


Cys His Trp Ile Gly Thr Ala Ser Pro Leu Asn Leu Glu Asp Pro Asn 
            20                  25                  30          


Val Cys Ser His Trp Glu Ser Tyr Ser Val Thr Val Gln Glu Ser Tyr 
        35                  40                  45              


Pro His Pro Phe Asp Gln Ile Tyr Tyr Thr Ser Cys Thr Asp Ile Leu 
    50                  55                  60                  


Asn Trp Phe Lys Cys Thr Arg His Arg Val Ser Tyr Arg Thr Ala Tyr 
65                  70                  75                  80  


Arg His Gly Glu Lys Thr Met Tyr Arg Arg Lys Ser Gln Cys Cys Pro 
                85                  90                  95      


Gly Phe Tyr Glu Ser Gly Glu Met Cys Val Pro His Cys Ala Asp Lys 
            100                 105                 110         


Cys Val His Gly Arg Cys Ile Ala Pro Asn Thr Cys Gln Cys Glu Pro 
        115                 120                 125             


Gly Trp Gly Gly Thr Asn Cys Ser Ser Ala Cys Asp Gly Asp His Trp 
    130                 135                 140                 


Gly Pro His Cys Thr Ser Arg Cys Gln Cys Lys Asn Gly Ala Leu Cys 
145                 150                 155                 160 


Asn Pro Ile Thr Gly Ala Cys His Cys Ala Ala Gly Phe Arg Gly Trp 
                165                 170                 175     


Arg Cys Glu Asp Arg Cys Glu Gln Gly Thr Tyr Gly Asn Asp Cys His 
            180                 185                 190         


Gln Arg Cys Gln Cys Gln Asn Gly Ala Thr Cys Asp His Val Thr Gly 
        195                 200                 205             


Glu Cys Arg Cys Pro Pro Gly Tyr Thr Gly Ala Phe Cys Glu Asp Leu 
    210                 215                 220                 


Cys Pro Pro Gly Lys His Gly Pro Gln Cys Glu Gln Arg Cys Pro Cys 
225                 230                 235                 240 


Gln Asn Gly Gly Val Cys His His Val Thr Gly Glu Cys Ser Cys Pro 
                245                 250                 255     


Ser Gly Trp Met Gly Thr Val Cys Gly Gln Pro Cys Pro Glu Gly Arg 
            260                 265                 270         


Phe Gly Lys Asn Cys Ser Gln Glu Cys Gln Cys His Asn Gly Gly Thr 
        275                 280                 285             


Cys Asp Ala Ala Thr Gly Gln Cys His Cys Ser Pro Gly Tyr Thr Gly 
    290                 295                 300                 


Glu Arg Cys Gln Asp Glu Cys Pro Val Gly Thr Tyr Gly Val Leu Cys 
305                 310                 315                 320 


Ala Glu Thr Cys Gln Cys Val Asn Gly Gly Lys Cys Tyr His Val Ser 
                325                 330                 335     


Gly Ala Cys Leu Cys Glu Ala Gly Phe Ala Gly Glu Arg Cys Glu Ala 
            340                 345                 350         


Arg Leu Cys Pro Glu Gly Leu Tyr Gly Ile Lys Cys Asp Lys Arg Cys 
        355                 360                 365             


Pro Cys His Leu Glu Asn Thr His Ser Cys His Pro Met Ser Gly Glu 
    370                 375                 380                 


Cys Ala Cys Lys Pro Gly Trp Ser Gly Leu Tyr Cys Asn Glu Thr Cys 
385                 390                 395                 400 


Ser Pro Gly Phe Tyr Gly Glu Ala Cys Gln Gln Ile Cys Ser Cys Gln 
                405                 410                 415     


Asn Gly Ala Asp Cys Asp Ser Val Thr Gly Lys Cys Thr Cys Ala Pro 
            420                 425                 430         


Gly Phe Lys Gly Ile Asp Cys Ser Thr Pro Cys Pro Leu Gly Thr Tyr 
        435                 440                 445             


Gly Ile Asn Cys Ser Ser Arg Cys Gly Cys Lys Asn Asp Ala Val Cys 
    450                 455                 460                 


Ser Pro Val Asp Gly Ser Cys Thr Cys Lys Ala Gly Trp His Gly Val 
465                 470                 475                 480 


Asp Cys Ser Ile Arg Cys Pro Ser Gly Thr Trp Gly Phe Gly Cys Asn 
                485                 490                 495     


Leu Thr Cys Gln Cys Leu Asn Gly Gly Ala Cys Asn Thr Leu Asp Gly 
            500                 505                 510         


Thr Cys Thr Cys Ala Pro Gly Trp Arg Gly Glu Lys Cys Glu Leu Pro 
        515                 520                 525             


Cys Gln Asp Gly Thr Tyr Gly Leu Asn Cys Ala Glu Arg Cys Asp Cys 
    530                 535                 540                 


Ser His Ala Asp Gly Cys His Pro Thr Thr Gly His Cys Arg Cys Leu 
545                 550                 555                 560 


Pro Gly Trp Ser Gly Leu Phe 
                565         


<210>  8510
<211>  1229
<212>  PRT
<213>  Homo Sapiens

<400>  8510

Met Gly Ala Ser Arg Asp Arg Gly Leu Ala Ala Leu Trp Cys Leu Gly 
1               5                   10                  15      


Leu Leu Gly Gly Leu Ala Arg Val Ala Gly Thr His Tyr Arg Tyr Leu 
            20                  25                  30          


Trp Arg Gly Cys Tyr Pro Cys His Leu Gly Gln Ala Gly Tyr Pro Val 
        35                  40                  45              


Ser Ala Gly Asp Gln Arg Pro Asp Val Asp Glu Cys Arg Thr His Asn 
    50                  55                  60                  


Gly Gly Cys Gln His Arg Cys Val Asn Thr Pro Gly Ser Tyr Leu Cys 
65                  70                  75                  80  


Glu Cys Lys Pro Gly Phe Arg Leu His Thr Asp Ser Arg Thr Cys Leu 
                85                  90                  95      


Ala Ile Asn Ser Cys Ala Leu Gly Asn Gly Gly Cys Gln His His Cys 
            100                 105                 110         


Val Gln Leu Thr Ile Thr Arg His Arg Cys Gln Cys Arg Pro Gly Phe 
        115                 120                 125             


Gln Leu Gln Glu Asp Gly Arg His Cys Val Arg Arg Ser Pro Cys Ala 
    130                 135                 140                 


Asn Arg Asn Gly Ser Cys Met His Arg Cys Gln Val Val Arg Gly Leu 
145                 150                 155                 160 


Ala Arg Cys Glu Cys His Val Gly Tyr Gln Leu Ala Ala Asp Gly Lys 
                165                 170                 175     


Ala Cys Glu Asp Val Asp Glu Cys Ala Ala Gly Leu Ala Gln Cys Ala 
            180                 185                 190         


His Gly Cys Leu Asn Thr Gln Gly Ser Phe Lys Cys Val Cys His Ala 
        195                 200                 205             


Gly Tyr Glu Leu Gly Ala Asp Gly Arg Gln Cys Tyr Arg Ile Glu Met 
    210                 215                 220                 


Glu Ile Val Asn Ser Cys Glu Ala Asn Asn Gly Gly Cys Ser His Gly 
225                 230                 235                 240 


Cys Ser His Thr Ser Ala Gly Pro Leu Cys Thr Cys Pro Arg Gly Tyr 
                245                 250                 255     


Glu Leu Asp Thr Asp Gln Arg Thr Cys Ile Asp Val Asp Asp Cys Ala 
            260                 265                 270         


Asp Ser Pro Cys Cys Gln Gln Val Cys Thr Asn Asn Pro Gly Gly Tyr 
        275                 280                 285             


Glu Cys Gly Cys Tyr Ala Gly Tyr Arg Leu Ser Ala Asp Gly Cys Gly 
    290                 295                 300                 


Cys Glu Asp Val Asp Glu Cys Ala Ser Ser Arg Gly Gly Cys Glu His 
305                 310                 315                 320 


His Cys Thr Asn Leu Ala Gly Ser Phe Gln Cys Ser Cys Glu Ala Gly 
                325                 330                 335     


Tyr Arg Leu His Glu Asp Arg Arg Gly Cys Ser Pro Leu Glu Glu Pro 
            340                 345                 350         


Met Val Asp Leu Asp Gly Glu Leu Pro Phe Val Arg Pro Leu Pro His 
        355                 360                 365             


Ile Ala Val Leu Gln Asp Glu Leu Pro Gln Leu Phe Gln Asp Asp Asp 
    370                 375                 380                 


Val Gly Ala Asp Glu Glu Glu Ala Glu Leu Arg Gly Glu His Thr Leu 
385                 390                 395                 400 


Thr Glu Lys Phe Val Cys Leu Asp Asp Ser Phe Gly His Asp Cys Ser 
                405                 410                 415     


Leu Thr Cys Asp Asp Cys Arg Asn Gly Gly Thr Cys Leu Leu Gly Leu 
            420                 425                 430         


Asp Gly Cys Asp Cys Pro Glu Gly Trp Thr Gly Leu Ile Cys Asn Glu 
        435                 440                 445             


Thr Cys Pro Pro Asp Thr Phe Gly Lys Asn Cys Ser Phe Ser Cys Ser 
    450                 455                 460                 


Cys Gln Asn Gly Gly Thr Cys Asp Ser Val Thr Gly Ala Cys Arg Cys 
465                 470                 475                 480 


Pro Pro Gly Val Ser Gly Thr Asn Cys Glu Asp Gly Cys Pro Lys Gly 
                485                 490                 495     


Tyr Tyr Gly Lys His Cys Arg Lys Lys Cys Asn Cys Ala Asn Arg Gly 
            500                 505                 510         


Arg Cys His Arg Leu Tyr Gly Ala Cys Leu Cys Asp Pro Gly Leu Tyr 
        515                 520                 525             


Gly Arg Phe Cys His Leu Thr Cys Pro Pro Trp Ala Phe Gly Pro Gly 
    530                 535                 540                 


Cys Ser Glu Glu Cys Gln Cys Val Gln Pro His Thr Gln Ser Cys Asp 
545                 550                 555                 560 


Lys Arg Asp Gly Ser Cys Ser Cys Lys Ala Gly Phe Arg Gly Glu Arg 
                565                 570                 575     


Cys Gln Ala Glu Cys Glu Leu Gly Tyr Phe Gly Pro Gly Cys Trp Gln 
            580                 585                 590         


Ala Cys Thr Cys Pro Val Gly Val Ala Cys Asp Ser Val Ser Gly Glu 
        595                 600                 605             


Cys Gly Lys Arg Cys Pro Ala Gly Phe Gln Gly Glu Asp Cys Gly Gln 
    610                 615                 620                 


Glu Cys Pro Val Gly Thr Phe Gly Val Asn Cys Ser Ser Ser Cys Ser 
625                 630                 635                 640 


Cys Gly Gly Ala Pro Cys His Gly Val Thr Gly Gln Cys Arg Cys Pro 
                645                 650                 655     


Pro Gly Arg Thr Gly Glu Asp Cys Glu Ala Asp Cys Pro Glu Gly Arg 
            660                 665                 670         


Trp Gly Leu Gly Cys Gln Glu Ile Cys Pro Ala Cys Gln His Ala Ala 
        675                 680                 685             


Arg Cys Asp Pro Glu Thr Gly Ala Cys Leu Cys Leu Pro Gly Phe Val 
    690                 695                 700                 


Gly Ser Arg Cys Gln Asp Val Cys Pro Ala Gly Trp Tyr Gly Pro Ser 
705                 710                 715                 720 


Cys Gln Thr Arg Cys Ser Cys Ala Asn Asp Gly His Cys His Pro Ala 
                725                 730                 735     


Thr Gly His Cys Ser Cys Ala Pro Gly Trp Thr Gly Phe Ser Cys Gln 
            740                 745                 750         


Arg Ala Cys Asp Thr Gly His Trp Gly Pro Asp Cys Ser His Pro Cys 
        755                 760                 765             


Asn Cys Ser Ala Gly His Gly Ser Cys Asp Ala Ile Ser Gly Leu Cys 
    770                 775                 780                 


Leu Cys Glu Ala Gly Tyr Val Gly Pro Arg Cys Glu Gln Gln Cys Pro 
785                 790                 795                 800 


Gln Gly His Phe Gly Pro Gly Cys Glu Gln Arg Cys Gln Cys Gln His 
                805                 810                 815     


Gly Ala Ala Cys Asp His Val Ser Gly Ala Cys Thr Cys Pro Ala Gly 
            820                 825                 830         


Trp Arg Gly Thr Phe Cys Glu His Ala Cys Pro Ala Gly Phe Phe Gly 
        835                 840                 845             


Leu Asp Cys Arg Ser Ala Cys Asn Cys Thr Ala Gly Ala Ala Cys Asp 
    850                 855                 860                 


Ala Val Asn Gly Ser Cys Leu Cys Pro Ala Gly Arg Arg Gly Pro Arg 
865                 870                 875                 880 


Cys Ala Glu Lys Cys Leu Pro Arg Asp Val Arg Ala Gly Cys Arg His 
                885                 890                 895     


Ser Gly Gly Cys Leu Asn Gly Gly Leu Cys Asp Pro His Thr Gly Arg 
            900                 905                 910         


Cys Leu Cys Pro Ala Gly Trp Thr Gly Asp Lys Cys Gln Ser Pro Cys 
        915                 920                 925             


Leu Arg Gly Trp Phe Gly Glu Ala Cys Ala Gln Arg Cys Ser Cys Pro 
    930                 935                 940                 


Pro Gly Ala Ala Cys His His Val Thr Gly Ala Cys Arg Cys Pro Pro 
945                 950                 955                 960 


Gly Phe Thr Gly Ser Gly Cys Glu Gln Gly Cys Pro Pro Gly Arg Tyr 
                965                 970                 975     


Gly Pro Gly Cys Glu Gln Leu Cys Gly Cys Leu Asn Gly Gly Ser Cys 
            980                 985                 990         


Asp Ala Ala Thr Gly Ala Cys Arg  Cys Pro Thr Gly Phe  Leu Gly Thr 
        995                 1000                 1005             


Asp Cys  Asn Leu Thr Cys Pro  Gln Gly Arg Phe Gly  Pro Asn Cys 
    1010                 1015                 1020             


Thr His  Val Cys Gly Cys Gly  Gln Gly Ala Ala Cys  Asp Pro Val 
    1025                 1030                 1035             


Thr Gly  Thr Cys Leu Cys Pro  Pro Gly Arg Ala Gly  Val Arg Cys 
    1040                 1045                 1050             


Glu Arg  Gly Cys Pro Gln Asn  Arg Phe Gly Val Gly  Cys Glu His 
    1055                 1060                 1065             


Thr Cys  Ser Cys Arg Asn Gly  Gly Leu Cys His Ala  Ser Asn Gly 
    1070                 1075                 1080             


Ser Cys  Ser Cys Gly Leu Gly  Trp Thr Gly Arg His  Cys Glu Leu 
    1085                 1090                 1095             


Ala Cys  Pro Pro Gly Arg Tyr  Gly Ala Ala Cys His  Leu Glu Cys 
    1100                 1105                 1110             


Ser Cys  His Asn Asn Ser Thr  Cys Glu Pro Ala Thr  Gly Thr Cys 
    1115                 1120                 1125             


Arg Cys  Gly Pro Gly Phe Tyr  Gly Gln Ala Cys Glu  His Arg Arg 
    1130                 1135                 1140             


Ser Gly  Ala Thr Cys Asn Leu  Asp Cys Arg Arg Gly  Gln Phe Gly 
    1145                 1150                 1155             


Pro Ser  Cys Thr Leu His Cys  Asp Cys Gly Gly Gly  Ala Asp Cys 
    1160                 1165                 1170             


Asp Pro  Val Ser Gly Gln Cys  His Cys Val Asp Gly  Tyr Met Gly 
    1175                 1180                 1185             


Pro Thr  Cys Arg Glu Gly Gly  Pro Leu Arg Leu Pro  Glu Asn Pro 
    1190                 1195                 1200             


Ser Leu  Ala Gln Gly Ser Ala  Gly Thr Leu Pro Ala  Ser Ser Arg 
    1205                 1210                 1215             


Pro Thr  Ser Arg Ser Gly Gly  Pro Ala Arg His 
    1220                 1225                 


<210>  8511
<211>  1541
<212>  PRT
<213>  Homo Sapiens

<400>  8511

Met Ser Phe Leu Glu Glu Ala Arg Ala Ala Gly Arg Ala Val Val Leu 
1               5                   10                  15      


Ala Leu Val Leu Leu Leu Leu Pro Ala Val Pro Val Gly Ala Ser Val 
            20                  25                  30          


Pro Pro Arg Pro Leu Leu Pro Leu Gln Pro Gly Met Pro His Val Cys 
        35                  40                  45              


Ala Glu Gln Glu Leu Thr Leu Val Gly Arg Arg Gln Pro Cys Val Gln 
    50                  55                  60                  


Ala Leu Ser His Thr Val Pro Val Trp Lys Ala Gly Cys Gly Trp Gln 
65                  70                  75                  80  


Ala Trp Cys Val Gly His Glu Arg Arg Thr Val Tyr Tyr Met Gly Tyr 
                85                  90                  95      


Arg Gln Val Tyr Thr Thr Glu Ala Arg Thr Val Leu Arg Cys Cys Arg 
            100                 105                 110         


Gly Trp Met Gln Gln Pro Asp Glu Glu Gly Cys Leu Ser Ala Glu Cys 
        115                 120                 125             


Ser Ala Ser Leu Cys Phe His Gly Gly Arg Cys Val Pro Gly Ser Ala 
    130                 135                 140                 


Gln Pro Cys His Cys Pro Pro Gly Phe Gln Gly Pro Arg Cys Gln Tyr 
145                 150                 155                 160 


Asp Val Asp Glu Cys Arg Thr His Asn Gly Gly Cys Gln His Arg Cys 
                165                 170                 175     


Val Asn Thr Pro Gly Ser Tyr Leu Cys Glu Cys Lys Pro Gly Phe Arg 
            180                 185                 190         


Leu His Thr Asp Ser Arg Thr Cys Leu Ala Ile Asn Ser Cys Ala Leu 
        195                 200                 205             


Gly Asn Gly Gly Cys Gln His His Cys Val Gln Leu Thr Ile Thr Arg 
    210                 215                 220                 


His Arg Cys Gln Cys Arg Pro Gly Phe Gln Leu Gln Glu Asp Gly Arg 
225                 230                 235                 240 


His Cys Val Arg Arg Ser Pro Cys Ala Asn Arg Asn Gly Ser Cys Met 
                245                 250                 255     


His Arg Cys Gln Val Val Arg Gly Leu Ala Arg Cys Glu Cys His Val 
            260                 265                 270         


Gly Tyr Gln Leu Ala Ala Asp Gly Lys Ala Cys Glu Asp Val Asp Glu 
        275                 280                 285             


Cys Ala Ala Gly Leu Ala Gln Cys Ala His Gly Cys Leu Asn Thr Gln 
    290                 295                 300                 


Gly Ser Phe Lys Cys Val Cys His Ala Gly Tyr Glu Leu Gly Ala Asp 
305                 310                 315                 320 


Gly Arg Gln Cys Tyr Arg Ile Glu Met Glu Ile Val Asn Ser Cys Glu 
                325                 330                 335     


Ala Asn Asn Gly Gly Cys Ser His Gly Cys Ser His Thr Ser Ala Gly 
            340                 345                 350         


Pro Leu Cys Thr Cys Pro Arg Gly Tyr Glu Leu Asp Thr Asp Gln Arg 
        355                 360                 365             


Thr Cys Ile Asp Val Asp Asp Cys Ala Asp Ser Pro Cys Cys Gln Gln 
    370                 375                 380                 


Val Cys Thr Asn Asn Pro Gly Gly Tyr Glu Cys Gly Cys Tyr Ala Gly 
385                 390                 395                 400 


Tyr Arg Leu Ser Ala Asp Gly Cys Gly Cys Glu Asp Val Asp Glu Cys 
                405                 410                 415     


Ala Ser Ser Arg Gly Gly Cys Glu His His Cys Thr Asn Leu Ala Gly 
            420                 425                 430         


Ser Phe Gln Cys Ser Cys Glu Ala Gly Tyr Arg Leu His Glu Asp Arg 
        435                 440                 445             


Arg Gly Cys Ser Pro Leu Glu Glu Pro Met Val Asp Leu Asp Gly Glu 
    450                 455                 460                 


Leu Pro Phe Val Arg Pro Leu Pro His Ile Ala Val Leu Gln Asp Glu 
465                 470                 475                 480 


Leu Pro Gln Leu Phe Gln Asp Asp Asp Val Gly Ala Asp Glu Glu Glu 
                485                 490                 495     


Ala Glu Leu Arg Gly Glu His Thr Leu Thr Glu Lys Phe Val Cys Leu 
            500                 505                 510         


Asp Asp Ser Phe Gly His Asp Cys Ser Leu Thr Cys Asp Asp Cys Arg 
        515                 520                 525             


Asn Gly Gly Thr Cys Leu Leu Gly Leu Asp Gly Cys Asp Cys Pro Glu 
    530                 535                 540                 


Gly Trp Thr Gly Leu Ile Cys Asn Glu Thr Cys Pro Pro Asp Thr Phe 
545                 550                 555                 560 


Gly Lys Asn Cys Ser Phe Ser Cys Ser Cys Gln Asn Gly Gly Thr Cys 
                565                 570                 575     


Asp Ser Val Thr Gly Ala Cys Arg Cys Pro Pro Gly Val Ser Gly Thr 
            580                 585                 590         


Asn Cys Glu Asp Gly Cys Pro Lys Gly Tyr Tyr Gly Lys His Cys Arg 
        595                 600                 605             


Lys Lys Cys Asn Cys Ala Asn Arg Gly Arg Cys His Arg Leu Tyr Gly 
    610                 615                 620                 


Ala Cys Leu Cys Asp Pro Gly Leu Tyr Gly Arg Phe Cys His Leu Thr 
625                 630                 635                 640 


Cys Pro Pro Trp Ala Phe Gly Pro Gly Cys Ser Glu Glu Cys Gln Cys 
                645                 650                 655     


Val Gln Pro His Thr Gln Ser Cys Asp Lys Arg Asp Gly Ser Cys Ser 
            660                 665                 670         


Cys Lys Ala Gly Phe Arg Gly Glu Arg Cys Gln Ala Glu Cys Glu Leu 
        675                 680                 685             


Gly Tyr Phe Gly Pro Gly Cys Trp Gln Ala Cys Thr Cys Pro Val Gly 
    690                 695                 700                 


Val Ala Cys Asp Ser Val Ser Gly Glu Cys Gly Lys Arg Cys Pro Ala 
705                 710                 715                 720 


Gly Phe Gln Gly Glu Asp Cys Gly Gln Glu Cys Pro Val Gly Thr Phe 
                725                 730                 735     


Gly Val Asn Cys Ser Ser Ser Cys Ser Cys Gly Gly Ala Pro Cys His 
            740                 745                 750         


Gly Val Thr Gly Gln Cys Arg Cys Pro Pro Gly Arg Thr Gly Glu Asp 
        755                 760                 765             


Cys Glu Ala Asp Cys Pro Glu Gly Arg Trp Gly Leu Gly Cys Gln Glu 
    770                 775                 780                 


Ile Cys Pro Ala Cys Gln His Ala Ala Arg Cys Asp Pro Glu Thr Gly 
785                 790                 795                 800 


Ala Cys Leu Cys Leu Pro Gly Phe Val Gly Ser Arg Cys Gln Asp Val 
                805                 810                 815     


Cys Pro Ala Gly Trp Tyr Gly Pro Ser Cys Gln Thr Arg Cys Ser Cys 
            820                 825                 830         


Ala Asn Asp Gly His Cys His Pro Ala Thr Gly His Cys Ser Cys Ala 
        835                 840                 845             


Pro Gly Trp Thr Gly Phe Ser Cys Gln Arg Ala Cys Asp Thr Gly His 
    850                 855                 860                 


Trp Gly Pro Asp Cys Ser His Pro Cys Asn Cys Ser Ala Gly His Gly 
865                 870                 875                 880 


Ser Cys Asp Ala Ile Ser Gly Leu Cys Leu Cys Glu Ala Gly Tyr Val 
                885                 890                 895     


Gly Pro Arg Cys Glu Gln Gln Cys Pro Gln Gly His Phe Gly Pro Gly 
            900                 905                 910         


Cys Glu Gln Arg Cys Gln Cys Gln His Gly Ala Ala Cys Asp His Val 
        915                 920                 925             


Ser Gly Ala Cys Thr Cys Pro Ala Gly Trp Arg Gly Thr Phe Cys Glu 
    930                 935                 940                 


His Ala Cys Pro Ala Gly Phe Phe Gly Leu Asp Cys Arg Ser Ala Cys 
945                 950                 955                 960 


Asn Cys Thr Ala Gly Ala Ala Cys Asp Ala Val Asn Gly Ser Cys Leu 
                965                 970                 975     


Cys Pro Ala Gly Arg Arg Gly Pro Arg Cys Ala Glu Thr Cys Pro Ala 
            980                 985                 990         


His Thr Tyr Gly His Asn Cys Ser  Gln Ala Cys Ala Cys  Phe Asn Gly 
        995                 1000                 1005             


Ala Ser  Cys Asp Pro Val His  Gly Gln Cys His Cys  Ala Pro Gly 
    1010                 1015                 1020             


Trp Met  Gly Pro Ser Cys Leu  Gln Ala Cys Pro Ala  Gly Leu Tyr 
    1025                 1030                 1035             


Gly Asp  Asn Cys Arg His Ser  Cys Leu Cys Gln Asn  Gly Gly Thr 
    1040                 1045                 1050             


Cys Asp  Pro Val Ser Gly His  Cys Ala Cys Pro Glu  Gly Trp Ala 
    1055                 1060                 1065             


Gly Leu  Ala Cys Glu Lys Glu  Cys Leu Pro Arg Asp  Val Arg Ala 
    1070                 1075                 1080             


Gly Cys  Arg His Ser Gly Gly  Cys Leu Asn Gly Gly  Leu Cys Asp 
    1085                 1090                 1095             


Pro His  Thr Gly Arg Cys Leu  Cys Pro Ala Gly Trp  Thr Gly Asp 
    1100                 1105                 1110             


Lys Cys  Gln Ser Pro Cys Leu  Arg Gly Trp Phe Gly  Glu Ala Cys 
    1115                 1120                 1125             


Ala Gln  Arg Cys Ser Cys Pro  Pro Gly Ala Ala Cys  His His Val 
    1130                 1135                 1140             


Thr Gly  Ala Cys Arg Cys Pro  Pro Gly Phe Thr Gly  Ser Gly Cys 
    1145                 1150                 1155             


Glu Gln  Ala Cys Pro Pro Gly  Ser Phe Gly Glu Asp  Cys Ala Gln 
    1160                 1165                 1170             


Met Cys  Gln Cys Pro Gly Glu  Asn Pro Ala Cys His  Pro Ala Thr 
    1175                 1180                 1185             


Gly Thr  Cys Ser Cys Ala Ala  Gly Tyr His Gly Pro  Ser Cys Gln 
    1190                 1195                 1200             


Gln Arg  Cys Pro Pro Gly Arg  Tyr Gly Pro Gly Cys  Glu Gln Leu 
    1205                 1210                 1215             


Cys Gly  Cys Leu Asn Gly Gly  Ser Cys Asp Ala Ala  Thr Gly Ala 
    1220                 1225                 1230             


Cys Arg  Cys Pro Thr Gly Phe  Leu Gly Thr Asp Cys  Asn Leu Thr 
    1235                 1240                 1245             


Cys Pro  Gln Gly Arg Phe Gly  Pro Asn Cys Thr His  Val Cys Gly 
    1250                 1255                 1260             


Cys Gly  Gln Gly Ala Ala Cys  Asp Pro Val Thr Gly  Thr Cys Leu 
    1265                 1270                 1275             


Cys Pro  Pro Gly Arg Ala Gly  Val Arg Cys Glu Arg  Gly Cys Pro 
    1280                 1285                 1290             


Gln Asn  Arg Phe Gly Val Gly  Cys Glu His Thr Cys  Ser Cys Arg 
    1295                 1300                 1305             


Asn Gly  Gly Leu Cys His Ala  Ser Asn Gly Ser Cys  Ser Cys Gly 
    1310                 1315                 1320             


Leu Gly  Trp Thr Gly Arg His  Cys Glu Leu Ala Cys  Pro Pro Gly 
    1325                 1330                 1335             


Arg Tyr  Gly Ala Ala Cys His  Leu Glu Cys Ser Cys  His Asn Asn 
    1340                 1345                 1350             


Ser Thr  Cys Glu Pro Ala Thr  Gly Thr Cys Arg Cys  Gly Pro Gly 
    1355                 1360                 1365             


Phe Tyr  Gly Gln Ala Cys Glu  His Pro Cys Pro Pro  Gly Phe His 
    1370                 1375                 1380             


Gly Ala  Gly Cys Gln Gly Leu  Cys Trp Cys Gln His  Gly Ala Pro 
    1385                 1390                 1395             


Cys Asp  Pro Ile Ser Gly Arg  Cys Leu Cys Pro Ala  Gly Phe His 
    1400                 1405                 1410             


Gly His  Phe Cys Glu Arg Gly  Cys Glu Pro Gly Ser  Phe Gly Glu 
    1415                 1420                 1425             


Gly Cys  His Gln Arg Cys Asp  Cys Asp Gly Gly Ala  Pro Cys Asp 
    1430                 1435                 1440             


Pro Val  Thr Gly Leu Cys Leu  Cys Pro Pro Gly Arg  Ser Gly Ala 
    1445                 1450                 1455             


Thr Cys  Asn Leu Asp Cys Arg  Arg Gly Gln Phe Gly  Pro Ser Cys 
    1460                 1465                 1470             


Thr Leu  His Cys Asp Cys Gly  Gly Gly Ala Asp Cys  Asp Pro Val 
    1475                 1480                 1485             


Ser Gly  Gln Cys His Cys Val  Asp Gly Tyr Met Gly  Pro Thr Cys 
    1490                 1495                 1500             


Arg Glu  Gly Gly Pro Leu Arg  Leu Pro Glu Asn Pro  Ser Leu Ala 
    1505                 1510                 1515             


Gln Gly  Ser Ala Gly Thr Leu  Pro Ala Ser Ser Arg  Pro Thr Ser 
    1520                 1525                 1530             


Arg Ser  Gly Gly Pro Ala Arg  His 
    1535                 1540     


<210>  8512
<211>  1323
<212>  PRT
<213>  Homo Sapiens

<400>  8512

Met Ser Phe Leu Glu Glu Ala Arg Ala Ala Gly Arg Ala Val Val Leu 
1               5                   10                  15      


Ala Leu Val Leu Leu Leu Leu Pro Ala Val Pro Val Gly Ala Ser Val 
            20                  25                  30          


Pro Pro Arg Pro Leu Leu Pro Leu Gln Pro Gly Met Pro His Val Cys 
        35                  40                  45              


Ala Glu Gln Glu Leu Thr Leu Val Gly Arg Arg Gln Pro Cys Val Gln 
    50                  55                  60                  


Ala Leu Ser His Thr Val Pro Val Trp Lys Ala Gly Cys Gly Trp Gln 
65                  70                  75                  80  


Ala Trp Cys Val Gly His Glu Arg Arg Thr Val Tyr Tyr Met Gly Tyr 
                85                  90                  95      


Arg Gln Val Tyr Thr Thr Glu Ala Arg Thr Val Leu Arg Cys Cys Arg 
            100                 105                 110         


Gly Trp Met Gln Gln Pro Asp Glu Glu Gly Cys Leu Ser Asp Val Gly 
        115                 120                 125             


Glu Cys Ala Asn Ala Asn Gly Gly Cys Ala Gly Arg Cys Arg Asp Thr 
    130                 135                 140                 


Val Gly Gly Phe Tyr Cys Arg Trp Pro Pro Pro Ser His Gln Leu Gln 
145                 150                 155                 160 


Gly Asp Gly Glu Thr Cys Gln Asp Val Asp Glu Cys Arg Thr His Asn 
                165                 170                 175     


Gly Gly Cys Gln His Arg Cys Val Asn Thr Pro Gly Ser Tyr Leu Cys 
            180                 185                 190         


Glu Cys Lys Pro Gly Phe Arg Leu His Thr Asp Ser Arg Thr Cys Leu 
        195                 200                 205             


Ala Ile Asn Ser Cys Ala Leu Gly Asn Gly Gly Cys Gln His His Cys 
    210                 215                 220                 


Val Gln Leu Thr Ile Thr Arg His Arg Cys Gln Cys Arg Pro Gly Phe 
225                 230                 235                 240 


Gln Leu Gln Glu Asp Gly Arg His Cys Val Arg Arg Ser Pro Cys Ala 
                245                 250                 255     


Asn Arg Asn Gly Ser Cys Met His Arg Cys Gln Val Val Arg Gly Leu 
            260                 265                 270         


Ala Arg Cys Glu Cys His Val Gly Tyr Gln Leu Ala Ala Asp Gly Lys 
        275                 280                 285             


Ala Cys Glu Asp Val Asp Glu Cys Ala Ala Gly Leu Ala Gln Cys Ala 
    290                 295                 300                 


His Gly Cys Leu Asn Thr Gln Gly Ser Phe Lys Cys Val Cys His Ala 
305                 310                 315                 320 


Gly Tyr Glu Leu Gly Ala Asp Gly Arg Gln Cys Tyr Arg Ile Glu Met 
                325                 330                 335     


Glu Ile Val Asn Ser Cys Glu Ala Asn Asn Gly Gly Cys Ser His Gly 
            340                 345                 350         


Cys Ser His Thr Ser Ala Gly Pro Leu Cys Thr Cys Pro Arg Gly Tyr 
        355                 360                 365             


Glu Leu Asp Thr Asp Gln Arg Thr Cys Ile Asp Val Asp Asp Cys Ala 
    370                 375                 380                 


Asp Ser Pro Cys Cys Gln Gln Val Cys Thr Asn Asn Pro Gly Gly Tyr 
385                 390                 395                 400 


Glu Cys Gly Cys Tyr Ala Gly Tyr Arg Leu Ser Ala Asp Gly Cys Gly 
                405                 410                 415     


Cys Glu Asp Val Asp Glu Cys Ala Ser Ser Arg Gly Gly Cys Glu His 
            420                 425                 430         


His Cys Thr Asn Leu Ala Gly Ser Phe Gln Cys Ser Cys Glu Ala Gly 
        435                 440                 445             


Tyr Arg Leu His Glu Asp Arg Arg Gly Cys Ser Pro Leu Glu Glu Pro 
    450                 455                 460                 


Met Val Asp Leu Asp Gly Glu Leu Pro Phe Val Arg Pro Leu Pro His 
465                 470                 475                 480 


Ile Ala Val Leu Gln Asp Glu Leu Pro Gln Leu Phe Gln Asp Asp Asp 
                485                 490                 495     


Val Gly Ala Asp Glu Glu Glu Ala Glu Leu Arg Gly Glu His Thr Leu 
            500                 505                 510         


Thr Glu Lys Phe Val Cys Leu Asp Asp Ser Phe Gly His Asp Cys Ser 
        515                 520                 525             


Leu Thr Cys Asp Asp Cys Arg Asn Gly Gly Thr Cys Leu Leu Gly Leu 
    530                 535                 540                 


Asp Gly Cys Asp Cys Pro Glu Gly Trp Thr Gly Leu Ile Cys Asn Glu 
545                 550                 555                 560 


Thr Cys Pro Pro Asp Thr Phe Gly Lys Asn Cys Ser Phe Ser Cys Ser 
                565                 570                 575     


Cys Gln Asn Gly Gly Thr Cys Asp Ser Val Thr Gly Ala Cys Arg Cys 
            580                 585                 590         


Pro Pro Gly Val Ser Gly Thr Asn Cys Glu Asp Gly Cys Pro Lys Gly 
        595                 600                 605             


Tyr Tyr Gly Lys His Cys Arg Lys Lys Cys Asn Cys Ala Asn Arg Gly 
    610                 615                 620                 


Arg Cys His Arg Leu Tyr Gly Ala Cys Leu Cys Asp Pro Gly Leu Tyr 
625                 630                 635                 640 


Gly Arg Phe Cys His Leu Thr Cys Pro Pro Trp Ala Phe Gly Pro Gly 
                645                 650                 655     


Cys Ser Glu Glu Cys Gln Cys Val Gln Pro His Thr Gln Ser Cys Asp 
            660                 665                 670         


Lys Arg Asp Gly Ser Cys Ser Cys Lys Ala Gly Phe Arg Gly Glu Arg 
        675                 680                 685             


Cys Gln Ala Glu Cys Glu Leu Gly Tyr Phe Gly Pro Gly Cys Trp Gln 
    690                 695                 700                 


Ala Cys Thr Cys Pro Val Gly Val Ala Cys Asp Ser Val Ser Gly Glu 
705                 710                 715                 720 


Cys Gly Lys Arg Cys Pro Ala Gly Phe Gln Gly Glu Asp Cys Gly Gln 
                725                 730                 735     


Glu Cys Pro Val Gly Thr Phe Gly Val Asn Cys Ser Ser Ser Cys Ser 
            740                 745                 750         


Cys Gly Gly Ala Pro Cys His Gly Val Thr Gly Gln Cys Arg Cys Pro 
        755                 760                 765             


Pro Gly Arg Thr Gly Glu Asp Cys Glu Ala Asp Cys Pro Glu Gly Arg 
    770                 775                 780                 


Trp Gly Leu Gly Cys Gln Glu Ile Cys Pro Ala Cys Gln His Ala Ala 
785                 790                 795                 800 


Arg Cys Asp Pro Glu Thr Gly Ala Cys Leu Cys Leu Pro Gly Phe Val 
                805                 810                 815     


Gly Ser Arg Cys Gln Asp Val Cys Pro Ala Gly Trp Tyr Gly Pro Ser 
            820                 825                 830         


Cys Gln Thr Arg Cys Ser Cys Ala Asn Asp Gly His Cys His Pro Ala 
        835                 840                 845             


Thr Gly His Cys Ser Cys Ala Pro Gly Trp Thr Gly Phe Ser Cys Gln 
    850                 855                 860                 


Arg Ala Cys Asp Thr Gly His Trp Gly Pro Asp Cys Ser His Pro Cys 
865                 870                 875                 880 


Asn Cys Ser Ala Gly His Gly Ser Cys Asp Ala Ile Ser Gly Leu Cys 
                885                 890                 895     


Leu Cys Glu Ala Gly Tyr Val Gly Pro Arg Cys Glu Gln Gln Cys Pro 
            900                 905                 910         


Gln Gly His Phe Gly Pro Gly Cys Glu Gln Arg Cys Gln Cys Gln His 
        915                 920                 925             


Gly Ala Ala Cys Asp His Val Ser Gly Ala Cys Thr Cys Pro Ala Gly 
    930                 935                 940                 


Trp Arg Gly Thr Phe Cys Glu His Ala Cys Pro Ala Gly Phe Phe Gly 
945                 950                 955                 960 


Leu Asp Cys Arg Ser Ala Cys Asn Cys Thr Ala Gly Ala Ala Cys Asp 
                965                 970                 975     


Ala Val Asn Gly Ser Cys Leu Cys Pro Ala Gly Arg Arg Gly Pro Arg 
            980                 985                 990         


Cys Ala Glu Thr Cys Pro Ala His  Thr Tyr Gly His Asn  Cys Ser Gln 
        995                 1000                 1005             


Ala Cys  Ala Cys Phe Asn Gly  Ala Ser Cys Asp Pro  Val His Gly 
    1010                 1015                 1020             


Gln Cys  His Cys Ala Pro Gly  Trp Met Gly Pro Ser  Cys Leu Gln 
    1025                 1030                 1035             


Ala Cys  Pro Ala Gly Leu Tyr  Gly Asp Asn Cys Arg  His Ser Cys 
    1040                 1045                 1050             


Leu Cys  Gln Asn Gly Gly Thr  Cys Asp Pro Val Ser  Gly His Cys 
    1055                 1060                 1065             


Ala Cys  Pro Glu Gly Trp Ala  Gly Leu Ala Cys Glu  Lys Glu Cys 
    1070                 1075                 1080             


Leu Pro  Arg Asp Val Arg Ala  Gly Cys Arg His Ser  Gly Gly Cys 
    1085                 1090                 1095             


Leu Asn  Gly Gly Leu Cys Asp  Pro His Thr Gly Arg  Cys Leu Cys 
    1100                 1105                 1110             


Pro Ala  Gly Trp Thr Gly Asp  Lys Cys Gln Ser Pro  Cys Ala Lys 
    1115                 1120                 1125             


Gly Thr  Phe Gly Pro His Cys  Glu Gly Arg Cys Ala  Cys Arg Trp 
    1130                 1135                 1140             


Gly Gly  Pro Cys His Leu Ala  Thr Gly Ala Cys Leu  Cys Pro Pro 
    1145                 1150                 1155             


Gly Trp  Arg Gly Ala Pro Gly  Val Arg Met Pro Ala  Cys Gly Ala 
    1160                 1165                 1170             


Gly Leu  Glu Arg Pro Val Pro  Ser Ala Ala Ala Ala  Arg Leu Ala 
    1175                 1180                 1185             


Leu Pro  Ala Thr Thr Ser Leu  Gly Pro Ala Ala Val  Pro Leu Ala 
    1190                 1195                 1200             


Ser Leu  Ala Pro Ala Ala Ser  Arg Pro Ala His Pro  Ala Ala Leu 
    1205                 1210                 1215             


Gly Arg  Thr Val Arg Arg Cys  Ala Ser Val Pro Val  Arg Thr Arg 
    1220                 1225                 1230             


Pro Ala  Thr Leu Pro Pro Gly  Pro Ala His Val Leu  Leu Ala Thr 
    1235                 1240                 1245             


Thr Ala  Pro Ala Ala Ser Asn  Asp Val Arg Pro Gly  Gly Met Gly 
    1250                 1255                 1260             


Gln Ala  Val Asn Ser Cys Val  Gly Val Ser Thr Gly  Ala Pro Val 
    1265                 1270                 1275             


Met Arg  Pro Arg Gly Pro Ala  Ala Ala Pro Leu Gly  Ser Ser Gly 
    1280                 1285                 1290             


Arg Thr  Ala Thr Ser Pro Val  Arg Arg Ala Ala Ser  Ala Pro Thr 
    1295                 1300                 1305             


Ala Pro  Thr Cys Val Gly Val  Gly Arg Gly Arg Pro  Ala Thr Leu 
    1310                 1315                 1320             


<210>  8513
<211>  248
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8513

Xaa Asp Ala Ala Thr Gly Ala Cys Arg Cys Pro Thr Gly Phe Leu Gly 
1               5                   10                  15      


Thr Asp Cys Asn Leu Thr Cys Pro Gln Gly Arg Phe Gly Pro Asn Cys 
            20                  25                  30          


Thr His Val Cys Gly Cys Gly Gln Gly Ala Ala Cys Asp Pro Val Thr 
        35                  40                  45              


Gly Thr Cys Leu Cys Pro Pro Gly Arg Ala Gly Val Arg Cys Glu Arg 
    50                  55                  60                  


Gly Cys Pro Gln Asn Arg Phe Gly Val Gly Cys Glu His Thr Cys Ser 
65                  70                  75                  80  


Cys Arg Asn Gly Gly Leu Cys His Ala Ser Asn Gly Ser Cys Ser Cys 
                85                  90                  95      


Gly Leu Gly Trp Thr Gly Arg His Cys Glu Leu Ala Cys Pro Pro Gly 
            100                 105                 110         


Arg Tyr Gly Ala Ala Cys His Leu Glu Cys Ser Cys His Asn Asn Ser 
        115                 120                 125             


Thr Cys Glu Pro Ala Thr Gly Thr Cys Arg Cys Gly Pro Gly Phe Tyr 
    130                 135                 140                 


Gly Gln Ala Cys Glu His Pro Cys Pro Pro Gly Phe His Gly Ala Gly 
145                 150                 155                 160 


Cys Gln Gly Leu Cys Trp Cys Gln His Gly Ala Pro Cys Asp Pro Ile 
                165                 170                 175     


Ser Gly Arg Cys Leu Cys Pro Ala Gly Phe His Gly His Phe Cys Glu 
            180                 185                 190         


Arg Asp Cys Arg Arg Gly Gln Phe Gly Pro Ser Cys Thr Leu His Cys 
        195                 200                 205             


Asp Cys Gly Gly Gly Ala Asp Cys Asp Pro Val Ser Gly Gln Cys His 
    210                 215                 220                 


Cys Val Asp Gly Tyr Met Gly Pro Thr Cys Arg Glu Gly Gly Pro Leu 
225                 230                 235                 240 


Arg Leu Pro Glu Asn Pro Ser Leu 
                245             


<210>  8514
<211>  1274
<212>  PRT
<213>  Homo Sapiens

<400>  8514

Met Ala Val Arg Gln Ala Ala Thr Ala Gly Thr Pro Gly Pro Arg Arg 
1               5                   10                  15      


Glu Glu Glu Ala Ala Leu Leu Phe Glu Arg Ala His Tyr Arg His Asp 
            20                  25                  30          


Pro Arg Trp Leu Leu Pro Val Thr Pro Arg Leu Cys Leu Ala Cys Ala 
        35                  40                  45              


Leu Glu Leu Leu Pro Asp Pro Gly Val Ser Leu Val Arg Lys Lys His 
    50                  55                  60                  


Met Leu Ser Cys Phe Gln Asp Ala Leu Val Arg His Thr Ser Leu Val 
65                  70                  75                  80  


Thr Gln Leu Val Ser Gln Asp Gln Arg Val Cys Ile His Phe Ile Ser 
                85                  90                  95      


Val Leu Phe Gly Leu Leu Cys Ser Met Glu Asp Gly Ser Val Thr Asp 
            100                 105                 110         


Leu Cys Ile Glu Val Leu Ile Gln Ile Thr Thr Gln Leu Lys Leu Glu 
        115                 120                 125             


Gln Thr Ile Arg Cys Leu Leu Asp Glu Cys His Lys Glu Leu Cys Asn 
    130                 135                 140                 


Met Pro Ser Met Arg Gly Ser Leu Ala Thr Leu Thr Leu Leu Gly Lys 
145                 150                 155                 160 


Leu Val Asp Ala Ile Pro Ala Leu Ala Asp Glu Leu Val Met Glu His 
                165                 170                 175     


Gly Asn Leu Met Glu His Leu Leu Arg Gly Leu Val Tyr Pro Ser Glu 
            180                 185                 190         


Gly Ile Gln Ala Ser Val Cys Tyr Leu Tyr Gly Lys Leu Tyr Ser Ser 
        195                 200                 205             


Pro Val Ala Ala Glu Met Leu Ser Gly His Phe Arg Glu Lys Leu Phe 
    210                 215                 220                 


Pro Leu Phe Leu Ser Ile Leu Asp Gly Ala Gln Thr Lys Glu Leu Gln 
225                 230                 235                 240 


Ile Asn Cys Leu Gly Leu Leu Arg Gln Leu Leu Lys Tyr Asp Leu Phe 
                245                 250                 255     


Val Ser Met Ile Met Asn Gln Asp Gly Leu Gly Glu Ser Ala Lys Asn 
            260                 265                 270         


Ile Glu Gly Ser Ser Gly Asn Thr Ser Leu Pro Leu Val Leu Lys Lys 
        275                 280                 285             


Leu Leu Leu Ser Arg Asp Glu Thr Leu Gln Val Ala Ser Ala His Cys 
    290                 295                 300                 


Ile Thr Ala Val Leu Val His Ser Pro Ala Lys His Ala Ser Ala Phe 
305                 310                 315                 320 


Ile His Ala Asp Ile Pro Glu Phe Leu Phe Glu His Leu Ser Ser Ser 
                325                 330                 335     


Ser Glu Val Leu Val Trp Ser Ser Cys Asn Cys Leu Thr Leu Leu Val 
            340                 345                 350         


Glu Glu Pro Leu Phe Phe Ser Lys Cys His Thr Val Tyr Gly Ile Glu 
        355                 360                 365             


Ala Val Val Arg Ser Leu Gln Gly Ser Leu Lys Met Asn Asn Ile Glu 
    370                 375                 380                 


Leu His Lys Gln Gly Leu Leu Leu Phe Ala Glu Ile Leu Thr Arg Gln 
385                 390                 395                 400 


Pro Glu Glu Ile Lys Leu Phe Thr Ser Ser Ala Met Cys Arg Asp Ala 
                405                 410                 415     


Gly Arg Ala Leu Gln Glu Ala Val Ser Ser Pro Val Leu Glu Val Ala 
            420                 425                 430         


Ala Glu Ala Leu Lys Ala Thr Ser Ala Phe Leu Arg Lys Asp His Gln 
        435                 440                 445             


Ser Thr Pro Pro Val Gln Tyr Gly Glu Leu Gln Ala Leu Leu Glu Ala 
    450                 455                 460                 


Met Leu Asn Arg Cys Ala Glu Phe Ser Gln Thr Leu Leu Ser Arg Arg 
465                 470                 475                 480 


Pro Leu Gly His Ala Ser Ser Arg Asp Ser Glu Lys Ala Ile Leu Gln 
                485                 490                 495     


Arg Gly Lys Phe Leu Leu Ser Thr Leu Glu Gly Phe Arg Ser Ala Cys 
            500                 505                 510         


Arg Leu Ala Ile Glu Phe Gln Ser Glu Pro Ser Ala Gln Glu Asn Pro 
        515                 520                 525             


Phe Thr Ala Pro Ser Ala Lys Lys Glu Asp Thr Leu Glu Ala Phe Ser 
    530                 535                 540                 


Glu Phe Leu Leu Ser Ala Cys Asp Ser Leu Cys Ile Pro Met Val Met 
545                 550                 555                 560 


Arg His Leu Glu Gln Thr Thr His Pro Ala Leu Met Glu Val Phe Leu 
                565                 570                 575     


Ser Ile Leu His Asn Leu Phe Val Ile Val Pro His Met Lys Glu Lys 
            580                 585                 590         


Phe Ser Lys Lys Leu Ala Ser Ser Ser Phe Ile Arg Leu Thr Leu Glu 
        595                 600                 605             


Leu Lys Ala Arg Phe Cys Ser Gly Leu Ser His Ser Ala Leu Asn Gln 
    610                 615                 620                 


Val Cys Ser Asn Phe Leu Tyr Tyr Met Cys Leu Asn Leu Leu Ser Ala 
625                 630                 635                 640 


Pro Glu Lys Thr Gly Pro Pro Ser Lys Glu Glu Leu Ser Ala Val Ser 
                645                 650                 655     


Glu Leu Leu Gln His Gly Leu Pro Gln Ile Ser Ser Arg Ser Pro Glu 
            660                 665                 670         


Ser Leu Ala Phe Leu Ser Asp Arg Gln Tyr Met Glu Gly Ala Ala Arg 
        675                 680                 685             


Gln Arg Gln Tyr Cys Ile Leu Leu Leu Phe Tyr Leu Ala Tyr Ile His 
    690                 695                 700                 


Glu Asp Arg Phe Val Ser Glu Ala Glu Leu Phe Glu Ala Val Gln Ser 
705                 710                 715                 720 


Phe Leu Leu Ser Leu Gln Asp Gln Gly Glu Arg Pro Pro Leu Val Val 
                725                 730                 735     


Phe Lys Ala Ser Ile Tyr Leu Leu Ala Ile Cys Gln Asp Lys Asp Asn 
            740                 745                 750         


Thr Leu Arg Glu Thr Met Val Ser Ala Ile Arg Lys Phe Leu Glu Gly 
        755                 760                 765             


Ile Pro Asp Leu Gln Leu Val Tyr Thr His His Pro Leu Leu Leu Arg 
    770                 775                 780                 


Phe Phe Leu Leu Tyr Pro Glu Leu Met Ser Arg Tyr Gly His Arg Val 
785                 790                 795                 800 


Leu Glu Leu Trp Phe Phe Trp Glu Glu Ser Ser Tyr Glu Glu Leu Asp 
                805                 810                 815     


Asp Val Thr Ser Ala Gly Gln Pro Ala Leu Pro Ala Ser Leu Val Val 
            820                 825                 830         


Leu Phe Gln Leu Leu Arg Ser Ile Pro Ser Ile Leu Leu Ile Leu Leu 
        835                 840                 845             


Asp Leu Ile Tyr Ser Ser Pro Val Asp Thr Ala His Lys Val Leu Ile 
    850                 855                 860                 


Ser Leu Arg Thr Phe Leu Arg Arg Asn Glu Asp Ile Gln Val Gly Gly 
865                 870                 875                 880 


Leu Ile Arg Gly His Phe Leu Leu Ile Leu Gln Arg Leu Leu Val Glu 
                885                 890                 895     


His Gly Ala Ser Pro Ser Gly Ala Ser Gly Asn Leu Pro Leu Leu Leu 
            900                 905                 910         


Ser Leu Leu Ser Leu Met Gln Leu Arg Asn Val Ser Glu Gln Glu Leu 
        915                 920                 925             


Asp Ser Val Ala Met Lys Leu Leu His Gln Val Ser Lys Leu Cys Gly 
    930                 935                 940                 


Lys Cys Ser Pro Thr Asp Val Asp Ile Leu Gln Pro Ser Phe Asn Phe 
945                 950                 955                 960 


Leu Tyr Trp Ser Leu His Gln Thr Thr Pro Ser Ser Gln Lys Arg Ala 
                965                 970                 975     


Ala Ala Val Leu Leu Ser Ser Thr Gly Leu Met Glu Leu Leu Glu Lys 
            980                 985                 990         


Met Leu Ala Leu Thr Leu Ala Lys  Ala Asp Ser Pro Arg  Thr Ala Leu 
        995                 1000                 1005             


Leu Cys  Ser Ala Trp Leu Leu  Thr Ala Ser Phe Ser  Ala Gln Gln 
    1010                 1015                 1020             


His Lys  Gly Ser Leu Gln Val  His Gln Thr Leu Ser  Val Glu Met 
    1025                 1030                 1035             


Asp Gln  Val Leu Lys Ala Leu  Ser Phe Pro Lys Lys  Lys Ala Ala 
    1040                 1045                 1050             


Leu Leu  Ser Ala Ala Ile Leu  Cys Phe Leu Arg Thr  Ala Leu Arg 
    1055                 1060                 1065             


Gln Ser  Phe Ser Ser Ala Leu  Val Ala Leu Val Pro  Ser Gly Ala 
    1070                 1075                 1080             


Gln Pro  Leu Pro Ala Thr Lys  Asp Thr Val Leu Ala  Pro Leu Arg 
    1085                 1090                 1095             


Met Ser  Gln Val Arg Ser Leu  Val Ile Gly Leu Gln  Asn Leu Leu 
    1100                 1105                 1110             


Val Gln  Lys Asp Pro Leu Leu  Ser Gln Ala Cys Val  Gly Cys Leu 
    1115                 1120                 1125             


Glu Ala  Leu Leu Asp Tyr Leu  Asp Ala Arg Ser Pro  Asp Ile Ala 
    1130                 1135                 1140             


Leu His  Val Ala Ser Gln Pro  Trp Asn Arg Phe Leu  Leu Phe Thr 
    1145                 1150                 1155             


Leu Leu  Asp Ala Gly Glu Asn  Ser Phe Leu Arg Pro  Glu Ile Leu 
    1160                 1165                 1170             


Arg Leu  Met Thr Leu Phe Met  Arg Tyr Arg Ser Ser  Ser Val Leu 
    1175                 1180                 1185             


Ser His  Glu Glu Val Gly Asp  Val Leu Gln Gly Val  Ala Leu Ala 
    1190                 1195                 1200             


Asp Leu  Ser Thr Leu Ser Asn  Thr Thr Leu Gln Ala  Leu His Gly 
    1205                 1210                 1215             


Phe Phe  Gln Gln Leu Gln Ser  Met Gly His Leu Ala  Asp His Ser 
    1220                 1225                 1230             


Met Ala  Gln Thr Leu Gln Ala  Ser Leu Glu Gly Leu  Pro Pro Ser 
    1235                 1240                 1245             


Thr Ser  Ser Gly Gln Pro Pro  Leu Gln Asp Met Leu  Cys Leu Gly 
    1250                 1255                 1260             


Gly Val  Ala Val Ser Leu Ser  His Ile Arg Asn 
    1265                 1270                 


<210>  8515
<211>  238
<212>  PRT
<213>  Homo Sapiens

<400>  8515

Met Leu Ala Leu Thr Leu Ala Lys Ala Asp Ser Pro Arg Thr Ala Leu 
1               5                   10                  15      


Leu Cys Ser Ala Trp Leu Leu Thr Ala Ser Phe Ser Ala Gln Gln His 
            20                  25                  30          


Lys Gly Ser Leu Gln Val His Gln Thr Leu Ser Val Glu Met Asp Gln 
        35                  40                  45              


Val Leu Lys Ala Leu Ser Phe Pro Lys Lys Lys Ala Ala Leu Leu Ser 
    50                  55                  60                  


Ala Ala Ile Leu Cys Phe Leu Arg Thr Ala Leu Arg Gln Ser Phe Ser 
65                  70                  75                  80  


Ser Ala Leu Val Ala Leu Val Pro Ser Gly Ala Gln Pro Leu Pro Ala 
                85                  90                  95      


Thr Lys Asp Thr Val Leu Ala Pro Leu Arg Met Ser Gln Val Arg Ser 
            100                 105                 110         


Leu Val Ile Gly Leu Gln Asn Leu Leu Val Gln Lys Asp Pro Leu Leu 
        115                 120                 125             


Ser Gln Ala Cys Val Gly Cys Leu Glu Ala Leu Leu Asp Tyr Leu Asp 
    130                 135                 140                 


Ala Arg Ser Pro Asp Ile Ala Leu His Val Ala Ser Gln Pro Trp Asn 
145                 150                 155                 160 


Arg Phe Leu Leu Phe Thr Leu Leu Asp Ala Gly Glu Asn Ser Phe Leu 
                165                 170                 175     


Arg Pro Glu Ile Leu Arg Leu Met Thr Leu Leu Gln Ser Met Gly His 
            180                 185                 190         


Leu Ala Asp His Ser Met Ala Gln Thr Leu Gln Ala Ser Leu Glu Gly 
        195                 200                 205             


Leu Pro Pro Ser Thr Ser Ser Gly Gln Pro Pro Leu Gln Asp Met Leu 
    210                 215                 220                 


Cys Leu Gly Gly Val Ala Val Ser Leu Ser His Ile Arg Asn 
225                 230                 235             


<210>  8516
<211>  506
<212>  PRT
<213>  Homo Sapiens

<400>  8516

Met Asn Gln Asp Gly Leu Gly Glu Ser Ala Lys Asn Ile Glu Gly Ser 
1               5                   10                  15      


Ser Gly Asn Thr Ser Leu Pro Leu Val Leu Lys Lys Leu Leu Leu Ser 
            20                  25                  30          


Arg Asp Glu Thr Leu Gln Val Ala Ser Ala His Cys Ile Thr Ala Val 
        35                  40                  45              


Leu Val His Ser Pro Ala Lys His Ala Ser Ala Phe Ile His Ala Asp 
    50                  55                  60                  


Ile Pro Glu Phe Leu Phe Glu His Leu Ser Ser Ser Ser Glu Val Leu 
65                  70                  75                  80  


Val Trp Ser Ser Cys Asn Cys Leu Thr Leu Leu Val Glu Glu Pro Leu 
                85                  90                  95      


Phe Phe Ser Lys Cys His Thr Val Tyr Gly Ile Glu Ala Val Val Arg 
            100                 105                 110         


Ser Leu Gln Gly Ser Leu Lys Met Asn Asn Ile Glu Leu His Lys Gln 
        115                 120                 125             


Gly Leu Leu Leu Phe Ala Glu Ile Leu Thr Arg Gln Pro Glu Glu Ile 
    130                 135                 140                 


Lys Leu Phe Thr Ser Ser Ala Met Cys Arg Asp Ala Gly Arg Ala Leu 
145                 150                 155                 160 


Gln Glu Ala Val Ser Ser Pro Val Leu Glu Val Ala Ala Glu Ala Leu 
                165                 170                 175     


Lys Ala Thr Ser Ala Phe Leu Arg Lys Asp His Gln Ser Thr Pro Pro 
            180                 185                 190         


Val Gln Tyr Gly Glu Leu Gln Ala Leu Leu Glu Ala Met Leu Asn Arg 
        195                 200                 205             


Cys Ala Glu Phe Ser Gln Thr Leu Leu Ser Arg Arg Pro Leu Gly His 
    210                 215                 220                 


Ala Ser Ser Arg Asp Ser Glu Lys Ala Ile Leu Gln Arg Gly Lys Phe 
225                 230                 235                 240 


Leu Leu Ser Thr Leu Glu Gly Phe Arg Ser Ala Cys Arg Leu Ala Ile 
                245                 250                 255     


Glu Phe Gln Ser Glu Pro Ser Ala Gln Glu Asn Pro Phe Thr Ala Pro 
            260                 265                 270         


Ser Ala Lys Lys Glu Asp Thr Leu Glu Ala Phe Ser Glu Phe Leu Leu 
        275                 280                 285             


Ser Ala Cys Asp Ser Leu Cys Ile Pro Met Val Met Arg His Leu Glu 
    290                 295                 300                 


Gln Thr Thr His Pro Ala Leu Met Glu Val Phe Leu Ser Ile Leu His 
305                 310                 315                 320 


Asn Leu Phe Val Ile Val Pro His Met Lys Glu Lys Phe Ser Lys Lys 
                325                 330                 335     


Leu Ala Ser Ser Ser Phe Ile Arg Leu Thr Leu Glu Leu Lys Ala Arg 
            340                 345                 350         


Phe Cys Ser Gly Leu Ser His Ser Ala Leu Asn Gln Val Cys Ser Asn 
        355                 360                 365             


Phe Leu Tyr Tyr Met Cys Leu Asn Leu Leu Ser Ala Pro Glu Lys Thr 
    370                 375                 380                 


Gly Pro Pro Ser Lys Glu Glu Leu Ser Ala Val Ser Glu Leu Leu Gln 
385                 390                 395                 400 


His Gly Leu Pro Gln Ile Ser Ser Arg Ser Pro Glu Ser Leu Ala Phe 
                405                 410                 415     


Leu Ser Asp Arg Gln Tyr Met Glu Gly Ala Ala Arg Gln Arg Gln Tyr 
            420                 425                 430         


Cys Ile Leu Leu Leu Phe Tyr Leu Ala Tyr Ile His Glu Asp Arg Phe 
        435                 440                 445             


Val Ser Glu Ala Glu Leu Phe Glu Ala Val Gln Ser Phe Leu Leu Ser 
    450                 455                 460                 


Leu Gln Asp Gln Gly Glu Arg Pro Pro Leu Val Val Phe Lys Ala Ser 
465                 470                 475                 480 


Ile Tyr Leu Leu Ala Ile Cys Gln Asp Lys Asp Asn Thr Leu Arg Glu 
                485                 490                 495     


Gln Leu His Cys Ser Leu Ile Ser Ile Ser 
            500                 505     


<210>  8517
<211>  63
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8517

Xaa Arg Ser Ser Ser Val Leu Ser His Glu Glu Leu Gln Ser Met Gly 
1               5                   10                  15      


His Leu Ala Asp His Ser Met Ala Gln Thr Leu Gln Ala Ser Leu Glu 
            20                  25                  30          


Gly Leu Pro Pro Ser Thr Ser Ser Gly Gln Pro Pro Leu Gln Asp Met 
        35                  40                  45              


Leu Cys Leu Gly Gly Val Ala Val Ser Leu Ser His Ile Arg Asn 
    50                  55                  60              


<210>  8518
<211>  385
<212>  PRT
<213>  Homo Sapiens

<400>  8518

Met Asp Val Gln Lys Trp Tyr Leu Arg Thr Ser Lys Leu Ala Leu Ala 
1               5                   10                  15      


Leu Ala Ile Ile Arg Ser Lys Pro Ala Asp Lys Ser Ser Arg Glu Tyr 
            20                  25                  30          


Thr Glu His Leu Ala Met Leu Leu Ser Glu Glu Gln Ser Lys Trp Arg 
        35                  40                  45              


Ser Lys Val Glu Ile Leu Glu Ala Glu Val Met Gln Leu Arg Gln Lys 
    50                  55                  60                  


Leu Leu Val Ser Arg Leu Cys Ser Gly Ser Phe Lys Ser Gly Tyr Val 
65                  70                  75                  80  


Ser Ser Gln Leu Glu Ala Gln Glu Pro Lys Ser Ser Glu Ser Thr Leu 
                85                  90                  95      


Thr Ser Met Glu Asp Ser Gly Cys Asp Leu Ser Asn Glu Gln Arg Thr 
            100                 105                 110         


Glu Ser Ser Asp Leu Ser Gln His Phe Val Glu Ser Cys Thr Pro Thr 
        115                 120                 125             


His Phe Pro Pro Leu Pro Leu Val Lys Arg Pro Cys Ala Ile Leu Gln 
    130                 135                 140                 


Asn Pro Leu Ser Ser His Met Gln Phe Leu Gln Tyr Leu Leu Glu Leu 
145                 150                 155                 160 


Lys Asn Leu Thr Glu Ser Gly Asn Leu Lys Arg Asp Leu Thr His Phe 
                165                 170                 175     


Glu Lys Asp Ser Ser Thr Val Ser Asp Ser Val Phe Gln Leu Leu Asp 
            180                 185                 190         


Gly Leu Ile Thr Phe Tyr Arg Asn Pro Lys Leu Pro Phe Ser Arg Phe 
        195                 200                 205             


Trp Thr Glu Ala Val Gly Thr Leu Ala Ser Leu Ile Ser Asp Tyr Asn 
    210                 215                 220                 


Leu Ser Ser His Ile Leu Lys Lys Cys Ser Lys Lys Leu Glu Glu Phe 
225                 230                 235                 240 


Glu Lys Thr Leu Leu His Ala Ile Leu Gly Asn Asn His Ile Asn Gln 
                245                 250                 255     


Phe Gln Val Gln His Tyr Val Ser Gln Ser Leu Val Thr Leu Gly Asn 
            260                 265                 270         


Cys Ser Leu Leu Arg Lys Ser Ile Ile Ser Leu Leu Leu Ser Glu Val 
        275                 280                 285             


Asn Gly Phe Ala Asp Asp Leu Gly Ala Ile Asn Gln Glu Gln Ala Ser 
    290                 295                 300                 


Tyr Asp Val Ser Arg Tyr Glu Asn Ile Phe Tyr Leu Phe Trp Val Leu 
305                 310                 315                 320 


Glu Gln Leu Leu Gln Lys Glu Thr Glu Glu Gly Asn Thr Ser Ser Ile 
                325                 330                 335     


Gly His Asp Asp Gln Glu Ile Lys Lys Phe Leu Gln Lys His Asp Glu 
            340                 345                 350         


Thr Ile Phe Gln Leu Ser Asp Ala Phe Pro Leu Phe Thr Phe Tyr Leu 
        355                 360                 365             


Trp Arg Val Gly Ile Leu Leu Ser Ser Ala Gln Ile Glu Thr Leu Arg 
    370                 375                 380                 


Lys 
385 


<210>  8519
<211>  325
<212>  PRT
<213>  Homo Sapiens

<400>  8519

Met Ala Gln Gly Leu Arg Leu Gln Gly Ser Arg Arg Lys Gly Arg His 
1               5                   10                  15      


Pro Leu Phe Pro Leu Leu Ala Leu Ile Phe Glu Lys Cys Glu Leu Ala 
            20                  25                  30          


Thr Cys Thr Pro Arg Glu Pro Gly Val Ala Gly Gly Asp Val Cys Ser 
        35                  40                  45              


Ser Glu Ser Phe Asn Glu Asp Ile Ala Val Phe Ala Lys Gln Ile Arg 
    50                  55                  60                  


Ala Glu Lys Pro Leu Phe Ser Ser Asn Pro Glu Leu Asp Asn Leu Met 
65                  70                  75                  80  


Ile Gln Ala Ile Gln Val Leu Arg Phe His Leu Leu Glu Leu Glu Lys 
                85                  90                  95      


Val His Glu Leu Cys Asp Asn Phe Cys His Arg Tyr Ile Ser Cys Leu 
            100                 105                 110         


Lys Gly Lys Met Pro Ile Asp Leu Val Ile Asp Asp Arg Glu Gly Gly 
        115                 120                 125             


Ser Lys Ser Asp Ser Glu Asp Ile Thr Arg Ser Ala Asn Leu Thr Asp 
    130                 135                 140                 


Gln Pro Ser Trp Asn Arg Asp His Asp Asp Thr Ala Ser Thr Arg Ser 
145                 150                 155                 160 


Gly Gly Thr Pro Gly Pro Ser Ser Gly Gly His Thr Ser His Ser Gly 
                165                 170                 175     


Asp Asn Ser Ser Glu Gln Gly Asp Gly Leu Asp Asn Ser Val Ala Ser 
            180                 185                 190         


Pro Ser Thr Gly Asp Asp Asp Asp Pro Asp Lys Asp Lys Lys Arg His 
        195                 200                 205             


Lys Lys Arg Gly Ile Phe Pro Lys Val Ala Thr Asn Ile Met Arg Ala 
    210                 215                 220                 


Trp Leu Phe Gln His Leu Thr His Pro Tyr Pro Ser Glu Glu Gln Lys 
225                 230                 235                 240 


Lys Gln Leu Ala Gln Asp Thr Gly Leu Thr Ile Leu Gln Val Asn Asn 
                245                 250                 255     


Trp Phe Ile Asn Ala Arg Arg Arg Ile Val Gln Pro Met Ile Asp Gln 
            260                 265                 270         


Ser Asn Arg Ala Val Ser Gln Gly Thr Pro Tyr Asn Pro Asp Gly Gln 
        275                 280                 285             


Pro Met Gly Gly Phe Val Met Asp Gly Gln Gln His Met Gly Ile Arg 
    290                 295                 300                 


Ala Pro Gly Pro Met Ser Gly Met Gly Met Asn Met Gly Met Glu Gly 
305                 310                 315                 320 


Gln Trp His Tyr Met 
                325 


<210>  8520
<211>  390
<212>  PRT
<213>  Homo Sapiens

<400>  8520

Met Ala Gln Arg Tyr Asp Asp Leu Pro His Tyr Gly Gly Met Asp Gly 
1               5                   10                  15      


Val Gly Ile Pro Ser Thr Met Tyr Gly Asp Pro His Ala Ala Arg Ser 
            20                  25                  30          


Met Gln Pro Val His His Leu Asn His Gly Pro Pro Leu His Ser His 
        35                  40                  45              


Gln Tyr Pro His Thr Ala His Thr Asn Ala Met Ala Pro Ser Met Gly 
    50                  55                  60                  


Ser Ser Val Asn Asp Ala Leu Lys Arg Asp Lys Asp Ala Ile Tyr Gly 
65                  70                  75                  80  


His Pro Leu Phe Pro Leu Leu Ala Leu Ile Phe Glu Lys Cys Glu Leu 
                85                  90                  95      


Ala Thr Cys Thr Pro Arg Glu Pro Gly Val Ala Gly Gly Asp Val Cys 
            100                 105                 110         


Ser Ser Glu Ser Phe Asn Glu Asp Ile Ala Val Phe Ala Lys Gln Ile 
        115                 120                 125             


Arg Ala Glu Lys Pro Leu Phe Ser Ser Asn Pro Glu Leu Asp Asn Leu 
    130                 135                 140                 


Met Ile Gln Ala Ile Gln Val Leu Arg Phe His Leu Leu Glu Leu Glu 
145                 150                 155                 160 


Lys Val His Glu Leu Cys Asp Asn Phe Cys His Arg Tyr Ile Ser Cys 
                165                 170                 175     


Leu Lys Gly Lys Met Pro Ile Asp Leu Val Ile Asp Asp Arg Glu Gly 
            180                 185                 190         


Gly Ser Lys Ser Asp Ser Glu Asp Ile Thr Arg Ser Ala Asn Leu Thr 
        195                 200                 205             


Asp Gln Pro Ser Trp Asn Arg Asp His Asp Asp Thr Ala Ser Thr Arg 
    210                 215                 220                 


Ser Gly Gly Thr Pro Gly Pro Ser Ser Gly Gly His Thr Ser His Ser 
225                 230                 235                 240 


Gly Asp Asn Ser Ser Glu Gln Gly Asp Gly Leu Asp Asn Ser Val Ala 
                245                 250                 255     


Ser Pro Ser Thr Gly Asp Asp Asp Asp Pro Asp Lys Asp Lys Lys Arg 
            260                 265                 270         


His Lys Lys Arg Gly Ile Phe Pro Lys Val Ala Thr Asn Ile Met Arg 
        275                 280                 285             


Ala Trp Leu Phe Gln His Leu Thr His Pro Tyr Pro Ser Glu Glu Gln 
    290                 295                 300                 


Lys Lys Gln Leu Ala Gln Asp Thr Gly Leu Thr Ile Leu Gln Val Asn 
305                 310                 315                 320 


Asn Trp Phe Ile Asn Ala Arg Arg Arg Ile Val Gln Pro Met Ile Asp 
                325                 330                 335     


Gln Ser Asn Arg Ala Val Ser Gln Gly Thr Pro Tyr Asn Pro Asp Gly 
            340                 345                 350         


Gln Pro Met Gly Gly Phe Val Met Asp Gly Gln Gln His Met Gly Ile 
        355                 360                 365             


Arg Ala Pro Gly Pro Met Ser Gly Met Gly Met Asn Met Gly Met Glu 
    370                 375                 380                 


Gly Gln Trp His Tyr Met 
385                 390 


<210>  8521
<211>  370
<212>  PRT
<213>  Homo Sapiens

<400>  8521

Met Ala Gln Arg Tyr Asp Asp Leu Pro His Tyr Gly Gly Met Asp Gly 
1               5                   10                  15      


Val Gly Ile Pro Ser Thr Met Tyr Gly Asp Pro His Ala Ala Arg Ser 
            20                  25                  30          


Met Gln Pro Val His His Leu Asn His Gly Pro Pro Leu His Ser His 
        35                  40                  45              


Gln Tyr Pro His Thr Ala His Thr Asn Ala Met Ala Pro Ser Met Gly 
    50                  55                  60                  


Ser Ser Val Asn Asp Ala Leu Lys Arg Asp Lys Asp Ala Ile Tyr Gly 
65                  70                  75                  80  


His Pro Leu Phe Pro Leu Leu Ala Leu Ile Phe Glu Lys Cys Glu Leu 
                85                  90                  95      


Ala Thr Cys Thr Pro Arg Glu Pro Gly Val Ala Gly Gly Asp Val Cys 
            100                 105                 110         


Ser Ser Glu Ser Phe Asn Glu Asp Ile Ala Val Phe Ala Lys Gln Ile 
        115                 120                 125             


Arg Ala Glu Lys Pro Leu Phe Ser Ser Asn Pro Glu Leu Asp Asn Leu 
    130                 135                 140                 


Met Ile Gln Ala Ile Gln Val Leu Arg Phe His Leu Leu Glu Leu Glu 
145                 150                 155                 160 


Lys Val His Glu Leu Cys Asp Asn Phe Cys His Arg Tyr Ile Ser Cys 
                165                 170                 175     


Leu Lys Gly Lys Met Pro Ile Asp Leu Val Ile Asp Asp Arg Glu Gly 
            180                 185                 190         


Gly Ser Lys Ser Asp Ser Glu Asp Ile Thr Arg Ser Ala Asn Leu Thr 
        195                 200                 205             


Asp Gln Pro Ser Trp Asn Arg Asp His Asp Asp Thr Ala Ser Thr Arg 
    210                 215                 220                 


Ser Gly Gly Thr Pro Gly Pro Ser Ser Gly Gly His Thr Ser His Ser 
225                 230                 235                 240 


Gly Asp Asn Ser Ser Glu Gln Gly Asp Gly Leu Asp Asn Ser Val Ala 
                245                 250                 255     


Ser Pro Ser Thr Gly Asp Asp Asp Asp Pro Asp Lys Asp Lys Lys Arg 
            260                 265                 270         


His Lys Lys Arg Gly Ile Phe Pro Lys Val Ala Thr Asn Ile Met Arg 
        275                 280                 285             


Ala Trp Leu Phe Gln His Leu Thr His Pro Tyr Pro Ser Glu Glu Gln 
    290                 295                 300                 


Lys Lys Gln Leu Ala Gln Asp Thr Gly Leu Thr Ile Leu Gln Val Asn 
305                 310                 315                 320 


Asn Trp Phe Ile Asn Ala Arg Arg Arg Ile Val Gln Pro Met Ile Asp 
                325                 330                 335     


Gln Ser Asn Arg Ala Gly Lys Ser Pro Ile Val Thr Val Phe Lys Ser 
            340                 345                 350         


Arg Lys Arg Lys Pro Ser Ser Ser His Ser Pro Gly Gly Pro Leu Pro 
        355                 360                 365             


Gly Lys 
    370 


<210>  8522
<211>  378
<212>  PRT
<213>  Homo Sapiens

<400>  8522

Met Ala Gln Arg Tyr Asp Asp Leu Pro His Tyr Gly Gly Met Asp Gly 
1               5                   10                  15      


Val Gly Ile Pro Ser Thr Met Tyr Gly Asp Pro His Ala Ala Arg Ser 
            20                  25                  30          


Met Gln Pro Val His His Leu Asn His Gly Pro Pro Leu His Ser His 
        35                  40                  45              


Gln Tyr Pro His Thr Ala His Thr Asn Ala Met Ala Pro Ser Met Gly 
    50                  55                  60                  


Ser Ser Val Asn Asp Ala Leu Lys Arg Asp Lys Asp Ala Ile Tyr Gly 
65                  70                  75                  80  


His Pro Leu Phe Pro Leu Leu Ala Leu Ile Phe Glu Lys Cys Glu Leu 
                85                  90                  95      


Ala Thr Cys Thr Pro Arg Glu Pro Gly Val Ala Gly Gly Asp Val Cys 
            100                 105                 110         


Ser Ser Glu Ser Phe Asn Glu Asp Ile Ala Val Phe Ala Lys Gln Ile 
        115                 120                 125             


Arg Ala Glu Lys Pro Leu Phe Ser Ser Asn Pro Glu Leu Asp Asn Leu 
    130                 135                 140                 


Met Ile Gln Ala Ile Gln Val Leu Arg Phe His Leu Leu Glu Leu Glu 
145                 150                 155                 160 


Lys Val His Glu Leu Cys Asp Asn Phe Cys His Arg Tyr Ile Ser Cys 
                165                 170                 175     


Leu Lys Gly Lys Met Pro Ile Asp Leu Val Ile Asp Asp Arg Glu Gly 
            180                 185                 190         


Gly Ser Lys Ser Asp Ser Glu Asp Ile Thr Arg Ser Ala Asn Leu Thr 
        195                 200                 205             


Asp Gln Pro Ser Trp Asn Arg Asp His Asp Asp Thr Ala Ser Thr Arg 
    210                 215                 220                 


Ser Gly Gly Thr Pro Gly Pro Ser Ser Gly Gly His Thr Ser His Ser 
225                 230                 235                 240 


Gly Asp Asn Ser Ser Glu Gln Gly Asp Gly Leu Asp Asn Ser Val Ala 
                245                 250                 255     


Ser Pro Ser Thr Gly Asp Asp Asp Asp Pro Asp Lys Asp Lys Lys Arg 
            260                 265                 270         


His Lys Lys Arg Gly Ile Phe Pro Lys Val Ala Thr Asn Ile Met Arg 
        275                 280                 285             


Ala Trp Leu Phe Gln His Leu Thr His Pro Tyr Pro Ser Glu Glu Gln 
    290                 295                 300                 


Lys Lys Gln Leu Ala Gln Asp Thr Gly Leu Thr Ile Leu Gln Val Asn 
305                 310                 315                 320 


Asn Trp Phe Ile Asn Ala Arg Arg Arg Ile Val Gln Pro Met Ile Asp 
                325                 330                 335     


Gln Ser Asn Arg Ala Val Ser Gln Gly Thr Pro Tyr Asn Pro Asp Gly 
            340                 345                 350         


Gln Pro Met Gly Gly Phe Val Met Asp Gly Gln Gln His Met Gly Ile 
        355                 360                 365             


Arg Ala Pro Gly Lys Thr Leu Phe Leu Trp 
    370                 375             


<210>  8523
<211>  463
<212>  PRT
<213>  Homo Sapiens

<400>  8523

Met Gln Tyr Asp Asp Leu Pro His Tyr Gly Gly Met Asp Gly Val Gly 
1               5                   10                  15      


Ile Pro Ser Thr Met Tyr Gly Asp Pro His Ala Ala Arg Ser Met Gln 
            20                  25                  30          


Pro Val His His Leu Asn His Gly Pro Pro Leu His Ser His Gln Tyr 
        35                  40                  45              


Pro His Thr Ala His Thr Asn Ala Met Ala Pro Ser Met Gly Ser Ser 
    50                  55                  60                  


Val Asn Asp Ala Leu Lys Arg Asp Lys Asp Ala Ile Tyr Gly His Pro 
65                  70                  75                  80  


Leu Phe Pro Leu Leu Ala Leu Ile Phe Glu Lys Cys Glu Leu Ala Thr 
                85                  90                  95      


Cys Thr Pro Arg Glu Pro Gly Val Ala Gly Gly Asp Val Cys Ser Ser 
            100                 105                 110         


Glu Ser Phe Asn Glu Asp Ile Ala Val Phe Ala Lys Gln Ile Arg Ala 
        115                 120                 125             


Glu Lys Pro Leu Phe Ser Ser Asn Pro Glu Leu Asp Asn Leu Met Ile 
    130                 135                 140                 


Gln Ala Ile Gln Val Leu Arg Phe His Leu Leu Glu Leu Glu Lys Val 
145                 150                 155                 160 


His Glu Leu Cys Asp Asn Phe Cys His Arg Tyr Ile Ser Cys Leu Lys 
                165                 170                 175     


Gly Lys Met Pro Ile Asp Leu Val Ile Asp Asp Arg Glu Gly Gly Ser 
            180                 185                 190         


Lys Ser Asp Ser Glu Asp Ile Thr Arg Ser Ala Asn Leu Thr Asp Gln 
        195                 200                 205             


Pro Ser Trp Asn Arg Asp His Asp Asp Thr Ala Ser Thr Arg Ser Gly 
    210                 215                 220                 


Gly Thr Pro Gly Pro Ser Ser Gly Gly His Thr Ser His Ser Gly Asp 
225                 230                 235                 240 


Asn Ser Ser Glu Gln Gly Asp Gly Leu Asp Asn Ser Val Ala Ser Pro 
                245                 250                 255     


Ser Thr Gly Asp Asp Asp Asp Pro Asp Lys Asp Lys Lys Arg His Lys 
            260                 265                 270         


Lys Arg Gly Ile Phe Pro Lys Val Ala Thr Asn Ile Met Arg Ala Trp 
        275                 280                 285             


Leu Phe Gln His Leu Thr His Pro Tyr Pro Ser Glu Glu Gln Lys Lys 
    290                 295                 300                 


Gln Leu Ala Gln Asp Thr Gly Leu Thr Ile Leu Gln Val Asn Asn Trp 
305                 310                 315                 320 


Phe Ile Asn Ala Arg Arg Arg Ile Val Gln Pro Met Ile Asp Gln Ser 
                325                 330                 335     


Asn Arg Ala Val Ser Gln Gly Thr Pro Tyr Asn Pro Asp Gly Gln Pro 
            340                 345                 350         


Met Gly Gly Phe Val Met Asp Gly Gln Gln His Met Gly Ile Arg Ala 
        355                 360                 365             


Pro Gly Leu Gln Ser Met Pro Gly Glu Tyr Val Ala Arg Gly Gly Pro 
    370                 375                 380                 


Met Gly Val Ser Met Gly Gln Pro Ser Tyr Thr Gln Pro Gln Met Pro 
385                 390                 395                 400 


Pro His Pro Ala Gln Leu Arg His Gly Pro Pro Met His Thr Tyr Ile 
                405                 410                 415     


Pro Gly His Pro His His Pro Thr Val Met Met His Gly Gly Pro Pro 
            420                 425                 430         


His Pro Gly Met Pro Met Ser Ala Ser Ser Pro Thr Val Leu Asn Thr 
        435                 440                 445             


Gly Asp Pro Thr Met Ser Gly Gln Val Met Asp Ile His Ala Gln 
    450                 455                 460             


<210>  8524
<211>  121
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8524

Xaa Leu Cys Phe Glu Ser Pro Glu Ile Ser Arg Pro Val Phe Pro Cys 
1               5                   10                  15      


Leu Gln Met Ile Gln Ala Ile Gln Val Leu Arg Phe His Leu Leu Glu 
            20                  25                  30          


Leu Glu Lys Val His Glu Leu Cys Asp Asn Phe Cys His Arg Tyr Ile 
        35                  40                  45              


Ser Cys Leu Lys Gly Lys Met Pro Ile Asp Leu Val Ile Asp Asp Arg 
    50                  55                  60                  


Glu Gly Gly Ser Lys Ser Asp Ser Glu Asp Ile Thr Arg Ser Ala Asn 
65                  70                  75                  80  


Leu Thr Asp Gln Pro Ser Trp Asn Arg Asp His Asp Asp Thr Ala Ser 
                85                  90                  95      


Thr Arg Ser Gly Gly Thr Pro Gly Pro Ser Ser Gly Gly His Thr Ser 
            100                 105                 110         


His Ser Gly Asp Asn Ser Ser Glu Gln 
        115                 120     


<210>  8525
<211>  126
<212>  PRT
<213>  Homo Sapiens

<400>  8525

Phe Pro Lys Val Ala Thr Asn Ile Met Arg Ala Trp Leu Phe Gln His 
1               5                   10                  15      


Leu Ser Ala Gly Ala Gly Arg His Val Ile Ala Pro Ser Leu Arg Leu 
            20                  25                  30          


Pro Trp Ser Pro Ser Trp Gly Ala Gln Arg Arg Ser Glu Ala Pro Val 
        35                  40                  45              


Leu Pro Asp Val Cys Leu Gly Leu Gly Ser Pro Ser Pro Gly Pro Arg 
    50                  55                  60                  


Trp Ala Arg Pro Trp Gly Ser Asp Cys Gly Arg Pro Gly Arg Gln Ser 
65                  70                  75                  80  


Asp Ser Cys Trp Trp Leu Gln His Pro Tyr Pro Ser Glu Glu Gln Lys 
                85                  90                  95      


Lys Gln Leu Ala Gln Asp Thr Gly Leu Thr Ile Leu Gln Val Asn Asn 
            100                 105                 110         


Trp Phe Ile Asn Ala Arg Arg Arg Ile Val Gln Pro Met Ile 
        115                 120                 125     


<210>  8526
<211>  404
<212>  PRT
<213>  Homo Sapiens

<400>  8526

Met Ala Arg Arg Tyr Asp Glu Leu Pro His Tyr Pro Gly Ile Val Asp 
1               5                   10                  15      


Gly Pro Ala Ala Leu Ala Ser Phe Pro Glu Thr Val Pro Ala Val Pro 
            20                  25                  30          


Gly Pro Tyr Gly Pro His Arg Pro Pro Gln Pro Leu Pro Pro Gly Leu 
        35                  40                  45              


Asp Ser Asp Gly Leu Lys Arg Glu Lys Asp Glu Ile Tyr Gly His Pro 
    50                  55                  60                  


Leu Phe Pro Leu Leu Ala Leu Val Phe Glu Lys Cys Glu Leu Ala Thr 
65                  70                  75                  80  


Cys Ser Pro Arg Asp Gly Ala Gly Ala Gly Leu Gly Thr Pro Pro Gly 
                85                  90                  95      


Gly Asp Val Cys Ser Ser Asp Ser Phe Asn Glu Asp Ile Ala Ala Phe 
            100                 105                 110         


Ala Lys Gln Val Arg Ser Glu Arg Pro Leu Phe Ser Ser Asn Pro Glu 
        115                 120                 125             


Leu Asp Asn Leu Met Ile Gln Ala Ile Gln Val Leu Arg Phe His Leu 
    130                 135                 140                 


Leu Glu Leu Glu Lys Gly Lys Met Pro Ile Asp Leu Val Ile Glu Asp 
145                 150                 155                 160 


Arg Asp Gly Gly Cys Arg Glu Asp Phe Glu Asp Tyr Pro Ala Ser Cys 
                165                 170                 175     


Pro Ser Leu Pro Asp Gln Asn Asn Met Trp Ile Arg Asp His Glu Asp 
            180                 185                 190         


Ser Gly Ser Val His Leu Gly Thr Pro Gly Pro Ser Ser Gly Gly Leu 
        195                 200                 205             


Ala Ser Gln Ser Gly Asp Asn Ser Ser Asp Gln Gly Asp Gly Leu Asp 
    210                 215                 220                 


Thr Ser Val Ala Ser Pro Ser Ser Gly Gly Glu Asp Glu Asp Leu Asp 
225                 230                 235                 240 


Gln Glu Arg Arg Arg Asn Lys Lys Arg Gly Ile Phe Pro Lys Val Ala 
                245                 250                 255     


Thr Asn Ile Met Arg Ala Trp Leu Phe Gln His Leu Ser Arg Arg Ser 
            260                 265                 270         


Glu Ala Pro Val Leu Pro Asp Val Cys Leu Gly Leu Gly Ser Pro Ser 
        275                 280                 285             


Pro Gly Pro Arg Trp Ala Arg Pro Trp Gly Ser Asp Cys Gly Arg Pro 
    290                 295                 300                 


Gly Arg Gln Ser Asp Ser Cys Trp Trp Leu Gln His Pro Tyr Pro Ser 
305                 310                 315                 320 


Glu Glu Gln Lys Lys Gln Leu Ala Gln Asp Thr Gly Leu Thr Ile Leu 
                325                 330                 335     


Gln Val Asn Asn Trp Phe Ile Asn Ala Arg Arg Arg Ile Val Gln Pro 
            340                 345                 350         


Met Ile Asp Gln Ser Asn Arg Thr Gly Gln Gly Ala Ala Phe Ser Pro 
        355                 360                 365             


Glu Gly Gln Pro Ile Gly Gly Tyr Thr Glu Thr Gln Pro His Val Ala 
    370                 375                 380                 


Val Arg Pro Pro Gly Ser Val Gly Met Ser Leu Asn Leu Glu Gly Glu 
385                 390                 395                 400 


Trp His Tyr Leu 
                


<210>  8527
<211>  358
<212>  PRT
<213>  Homo Sapiens

<400>  8527

Met Ala Arg Arg Tyr Asp Glu Leu Pro His Tyr Pro Gly Ile Val Asp 
1               5                   10                  15      


Gly Pro Ala Ala Leu Ala Ser Phe Pro Glu Thr Val Pro Ala Val Pro 
            20                  25                  30          


Gly Pro Tyr Gly Pro His Arg Pro Pro Gln Pro Leu Pro Pro Gly Leu 
        35                  40                  45              


Asp Ser Asp Gly Leu Lys Arg Glu Lys Asp Glu Ile Tyr Gly His Pro 
    50                  55                  60                  


Leu Phe Pro Leu Leu Ala Leu Val Phe Glu Lys Cys Glu Leu Ala Thr 
65                  70                  75                  80  


Cys Ser Pro Arg Asp Gly Ala Gly Ala Gly Leu Gly Thr Pro Pro Gly 
                85                  90                  95      


Gly Asp Val Cys Ser Ser Asp Ser Phe Asn Glu Asp Ile Ala Ala Phe 
            100                 105                 110         


Ala Lys Gln Val Arg Ser Glu Arg Pro Leu Phe Ser Ser Asn Pro Glu 
        115                 120                 125             


Leu Asp Asn Leu Met Ile Gln Ala Ile Gln Val Leu Arg Phe His Leu 
    130                 135                 140                 


Leu Glu Leu Glu Lys Gly Lys Met Pro Ile Asp Leu Val Ile Glu Asp 
145                 150                 155                 160 


Arg Asp Gly Gly Cys Arg Glu Asp Phe Glu Asp Tyr Pro Ala Ser Cys 
                165                 170                 175     


Pro Ser Leu Pro Asp Gln Asn Asn Met Trp Ile Arg Asp His Glu Asp 
            180                 185                 190         


Ser Gly Ser Val His Leu Gly Thr Pro Gly Pro Ser Ser Gly Gly Leu 
        195                 200                 205             


Ala Ser Gln Ser Gly Asp Asn Ser Ser Asp Gln Gly Asp Gly Leu Asp 
    210                 215                 220                 


Thr Ser Val Ala Ser Pro Ser Ser Gly Gly Glu Asp Glu Asp Leu Asp 
225                 230                 235                 240 


Gln Glu Arg Arg Arg Asn Lys Lys Arg Gly Ile Phe Pro Lys Val Ala 
                245                 250                 255     


Thr Asn Ile Met Arg Ala Trp Leu Phe Gln His Leu Ser His Pro Tyr 
            260                 265                 270         


Pro Ser Glu Glu Gln Lys Lys Gln Leu Ala Gln Asp Thr Gly Leu Thr 
        275                 280                 285             


Ile Leu Gln Val Asn Asn Trp Phe Ile Asn Ala Arg Arg Arg Ile Val 
    290                 295                 300                 


Gln Pro Met Ile Asp Gln Ser Asn Arg Thr Gly Gln Gly Ala Ala Phe 
305                 310                 315                 320 


Ser Pro Glu Gly Gln Pro Ile Gly Gly Tyr Thr Glu Thr Gln Pro His 
                325                 330                 335     


Val Ala Val Arg Pro Pro Gly Ser Val Gly Met Ser Leu Asn Leu Glu 
            340                 345                 350         


Gly Glu Trp His Tyr Leu 
        355             


<210>  8528
<211>  375
<212>  PRT
<213>  Homo Sapiens

<400>  8528

Met Ala Arg Arg Tyr Asp Glu Leu Pro His Tyr Pro Gly Ile Val Asp 
1               5                   10                  15      


Gly Pro Ala Ala Leu Ala Ser Phe Pro Glu Thr Val Pro Ala Val Pro 
            20                  25                  30          


Gly Pro Tyr Gly Pro His Arg Pro Pro Gln Pro Leu Pro Pro Gly Leu 
        35                  40                  45              


Asp Ser Asp Gly Leu Lys Arg Glu Lys Asp Glu Ile Tyr Gly His Pro 
    50                  55                  60                  


Leu Phe Pro Leu Leu Ala Leu Val Phe Glu Lys Cys Glu Leu Ala Thr 
65                  70                  75                  80  


Cys Ser Pro Arg Asp Gly Ala Gly Ala Gly Leu Gly Thr Pro Pro Gly 
                85                  90                  95      


Gly Asp Val Cys Ser Ser Asp Ser Phe Asn Glu Asp Ile Ala Ala Phe 
            100                 105                 110         


Ala Lys Gln Val Arg Ser Glu Arg Pro Leu Phe Ser Ser Asn Pro Glu 
        115                 120                 125             


Leu Asp Asn Leu Met Ile Gln Ala Ile Gln Val Leu Arg Phe His Leu 
    130                 135                 140                 


Leu Glu Leu Glu Lys Val His Asp Leu Cys Asp Asn Phe Cys His Arg 
145                 150                 155                 160 


Tyr Ile Thr Cys Leu Lys Gly Lys Met Pro Ile Asp Leu Val Ile Glu 
                165                 170                 175     


Asp Arg Asp Gly Gly Cys Arg Glu Asp Phe Glu Asp Tyr Pro Ala Ser 
            180                 185                 190         


Cys Pro Ser Leu Pro Asp Gln Asn Asn Met Trp Ile Arg Asp His Glu 
        195                 200                 205             


Asp Ser Gly Ser Val His Leu Gly Thr Pro Gly Pro Ser Ser Gly Gly 
    210                 215                 220                 


Leu Ala Ser Gln Ser Gly Asp Asn Ser Ser Asp Gln Gly Asp Gly Leu 
225                 230                 235                 240 


Asp Thr Ser Val Ala Ser Pro Ser Ser Gly Gly Glu Asp Glu Asp Leu 
                245                 250                 255     


Asp Gln Glu Arg Arg Arg Asn Lys Lys Arg Gly Ile Phe Pro Lys Val 
            260                 265                 270         


Ala Thr Asn Ile Met Arg Ala Trp Leu Phe Gln His Leu Ser His Pro 
        275                 280                 285             


Tyr Pro Ser Glu Glu Gln Lys Lys Gln Leu Ala Gln Asp Thr Gly Leu 
    290                 295                 300                 


Thr Ile Leu Gln Val Asn Asn Trp Phe Ile Asn Ala Arg Arg Arg Ile 
305                 310                 315                 320 


Val Gln Pro Met Ile Asp Gln Ser Asn Arg Thr Gly Gln Gly Ala Ala 
                325                 330                 335     


Phe Ser Pro Glu Gly Gln Pro Ile Gly Gly Tyr Thr Glu Thr Gln Pro 
            340                 345                 350         


His Val Ala Val Arg Pro Pro Gly Ser Val Gly Met Ser Leu Asn Leu 
        355                 360                 365             


Glu Gly Glu Trp His Tyr Leu 
    370                 375 


<210>  8529
<211>  421
<212>  PRT
<213>  Homo Sapiens

<400>  8529

Met Ala Arg Arg Tyr Asp Glu Leu Pro His Tyr Pro Gly Ile Val Asp 
1               5                   10                  15      


Gly Pro Ala Ala Leu Ala Ser Phe Pro Glu Thr Val Pro Ala Val Pro 
            20                  25                  30          


Gly Pro Tyr Gly Pro His Arg Pro Pro Gln Pro Leu Pro Pro Gly Leu 
        35                  40                  45              


Asp Ser Asp Gly Leu Lys Arg Glu Lys Asp Glu Ile Tyr Gly His Pro 
    50                  55                  60                  


Leu Phe Pro Leu Leu Ala Leu Val Phe Glu Lys Cys Glu Leu Ala Thr 
65                  70                  75                  80  


Cys Ser Pro Arg Asp Gly Ala Gly Ala Gly Leu Gly Thr Pro Pro Gly 
                85                  90                  95      


Gly Asp Val Cys Ser Ser Asp Ser Phe Asn Glu Asp Ile Ala Ala Phe 
            100                 105                 110         


Ala Lys Gln Val Arg Ser Glu Arg Pro Leu Phe Ser Ser Asn Pro Glu 
        115                 120                 125             


Leu Asp Asn Leu Met Ile Gln Ala Ile Gln Val Leu Arg Phe His Leu 
    130                 135                 140                 


Leu Glu Leu Glu Lys Val His Asp Leu Cys Asp Asn Phe Cys His Arg 
145                 150                 155                 160 


Tyr Ile Thr Cys Leu Lys Gly Lys Met Pro Ile Asp Leu Val Ile Glu 
                165                 170                 175     


Asp Arg Asp Gly Gly Cys Arg Glu Asp Phe Glu Asp Tyr Pro Ala Ser 
            180                 185                 190         


Cys Pro Ser Leu Pro Asp Gln Asn Asn Met Trp Ile Arg Asp His Glu 
        195                 200                 205             


Asp Ser Gly Ser Val His Leu Gly Thr Pro Gly Pro Ser Ser Gly Gly 
    210                 215                 220                 


Leu Ala Ser Gln Ser Gly Asp Asn Ser Ser Asp Gln Gly Asp Gly Leu 
225                 230                 235                 240 


Asp Thr Ser Val Ala Ser Pro Ser Ser Gly Gly Glu Asp Glu Asp Leu 
                245                 250                 255     


Asp Gln Glu Arg Arg Arg Asn Lys Lys Arg Gly Ile Phe Pro Lys Val 
            260                 265                 270         


Ala Thr Asn Ile Met Arg Ala Trp Leu Phe Gln His Leu Ser Arg Arg 
        275                 280                 285             


Ser Glu Ala Pro Val Leu Pro Asp Val Cys Leu Gly Leu Gly Ser Pro 
    290                 295                 300                 


Ser Pro Gly Pro Arg Trp Ala Arg Pro Trp Gly Ser Asp Cys Gly Arg 
305                 310                 315                 320 


Pro Gly Arg Gln Ser Asp Ser Cys Trp Trp Leu Gln His Pro Tyr Pro 
                325                 330                 335     


Ser Glu Glu Gln Lys Lys Gln Leu Ala Gln Asp Thr Gly Leu Thr Ile 
            340                 345                 350         


Leu Gln Val Asn Asn Trp Phe Ile Asn Ala Arg Arg Arg Ile Val Gln 
        355                 360                 365             


Pro Met Ile Asp Gln Ser Asn Arg Thr Gly Gln Gly Ala Ala Phe Ser 
    370                 375                 380                 


Pro Glu Gly Gln Pro Ile Gly Gly Tyr Thr Glu Thr Gln Pro His Val 
385                 390                 395                 400 


Ala Val Arg Pro Pro Gly Ser Val Gly Met Ser Leu Asn Leu Glu Gly 
                405                 410                 415     


Glu Trp His Tyr Leu 
            420     


<210>  8530
<211>  421
<212>  PRT
<213>  Homo Sapiens

<400>  8530

Met Ala Arg Arg Tyr Asp Glu Leu Pro His Tyr Pro Gly Ile Val Asp 
1               5                   10                  15      


Gly Pro Ala Ala Leu Ala Ser Phe Pro Glu Thr Val Pro Ala Val Pro 
            20                  25                  30          


Gly Pro Tyr Gly Pro His Arg Pro Pro Gln Pro Leu Pro Pro Gly Leu 
        35                  40                  45              


Asp Ser Asp Gly Leu Lys Arg Glu Lys Asp Glu Ile Tyr Gly His Pro 
    50                  55                  60                  


Leu Phe Pro Leu Leu Ala Leu Val Phe Glu Lys Cys Glu Leu Ala Thr 
65                  70                  75                  80  


Cys Ser Pro Arg Asp Gly Ala Gly Ala Gly Leu Gly Thr Pro Pro Gly 
                85                  90                  95      


Gly Asp Val Cys Ser Ser Asp Ser Phe Asn Glu Asp Ile Ala Ala Phe 
            100                 105                 110         


Ala Lys Gln Val Arg Ser Glu Arg Pro Leu Phe Ser Ser Asn Pro Glu 
        115                 120                 125             


Leu Asp Asn Leu Met Ile Gln Ala Ile Gln Val Leu Arg Phe His Leu 
    130                 135                 140                 


Leu Glu Leu Glu Lys Val His Asp Leu Cys Asp Asn Phe Cys His Arg 
145                 150                 155                 160 


Tyr Ile Thr Cys Leu Lys Gly Lys Met Pro Ile Asp Leu Val Ile Glu 
                165                 170                 175     


Asp Arg Asp Gly Gly Cys Arg Glu Asp Phe Glu Asp Tyr Pro Ala Ser 
            180                 185                 190         


Cys Pro Ser Leu Pro Asp Gln Asn Asn Met Trp Ile Arg Asp His Glu 
        195                 200                 205             


Asp Ser Gly Ser Val His Leu Gly Thr Pro Gly Pro Ser Ser Gly Gly 
    210                 215                 220                 


Leu Ala Ser Gln Ser Gly Asp Asn Ser Ser Asp Gln Gly Asp Gly Leu 
225                 230                 235                 240 


Asp Thr Ser Val Ala Ser Pro Ser Ser Gly Gly Glu Asp Glu Asp Leu 
                245                 250                 255     


Asp Gln Glu Arg Arg Arg Asn Lys Lys Arg Gly Ile Phe Pro Lys Val 
            260                 265                 270         


Ala Thr Asn Ile Met Arg Ala Trp Leu Phe Gln His Leu Ser Arg Arg 
        275                 280                 285             


Ser Glu Ala Pro Val Leu Pro Asp Val Cys Leu Gly Leu Gly Ser Pro 
    290                 295                 300                 


Ser Pro Gly Pro Arg Trp Ala Arg Pro Trp Gly Ser Asp Cys Gly Arg 
305                 310                 315                 320 


Pro Gly Arg Gln Ser Asp Ser Cys Trp Trp Leu Gln His Pro Tyr Pro 
                325                 330                 335     


Ser Glu Glu Gln Lys Lys Gln Leu Ala Gln Asp Thr Gly Leu Thr Ile 
            340                 345                 350         


Leu Gln Val Asn Asn Trp Phe Ile Asn Ala Arg Arg Arg Ile Val Gln 
        355                 360                 365             


Pro Met Ile Asp Gln Ser Asn Arg Thr Gly Gln Gly Ala Ala Phe Ser 
    370                 375                 380                 


Pro Glu Gly Gln Pro Ile Gly Gly Tyr Thr Glu Thr Gln Pro His Val 
385                 390                 395                 400 


Ala Val Arg Pro Pro Gly Ser Val Gly Met Ser Leu Asn Leu Glu Gly 
                405                 410                 415     


Glu Trp His Tyr Leu 
            420     


<210>  8531
<211>  221
<212>  PRT
<213>  Homo Sapiens

<400>  8531

Met Ala Arg Arg Tyr Asp Glu Leu Pro His Tyr Pro Gly Ile Val Asp 
1               5                   10                  15      


Gly Pro Ala Ala Leu Ala Ser Phe Pro Glu Thr Val Pro Ala Val Pro 
            20                  25                  30          


Gly Pro Tyr Gly Pro His Arg Pro Pro Gln Pro Leu Pro Pro Gly Leu 
        35                  40                  45              


Asp Ser Asp Gly Leu Lys Arg Glu Lys Asp Glu Ile Tyr Gly His Pro 
    50                  55                  60                  


Leu Phe Pro Leu Leu Ala Leu Val Phe Glu Lys Cys Glu Leu Ala Thr 
65                  70                  75                  80  


Cys Ser Pro Arg Asp Gly Ala Gly Ala Gly Leu Gly Thr Pro Pro Gly 
                85                  90                  95      


Gly Asp Val Cys Ser Ser Asp Ser Phe Asn Glu Asp Ile Ala Ala Phe 
            100                 105                 110         


Ala Lys Gln Val Arg Ser Glu Arg Pro Leu Phe Ser Ser Asn Pro Glu 
        115                 120                 125             


Leu Asp Asn Leu Met Ile Gln Ala Ile Gln Val Leu Arg Phe His Leu 
    130                 135                 140                 


Leu Glu Leu Glu Lys Val Ser Ala Ser His Leu Pro Thr Pro Ser Leu 
145                 150                 155                 160 


Ala Pro Val Ile Pro Pro Pro Leu Val Ala Ser Ala Pro His Leu Pro 
                165                 170                 175     


Ala Leu Ser Pro Pro Glu Leu Lys Gln Asn Ala Ala Pro Val Pro Glu 
            180                 185                 190         


His Pro Arg Pro Ala Pro Val Gly Gly Pro Pro Gln Tyr Pro Gly Ala 
        195                 200                 205             


Pro Pro Gly Pro Arg Pro Val Arg Gln Leu Leu Ser Pro 
    210                 215                 220     


<210>  8532
<211>  463
<212>  PRT
<213>  Homo Sapiens

<400>  8532

Met Cys Thr Leu Cys Thr Thr Met Arg Gly Ser Tyr Arg Arg Cys Pro 
1               5                   10                  15      


Trp Ile Ser Leu Ser Val Cys Leu Ser Leu Cys Leu Cys His Cys Leu 
            20                  25                  30          


Leu Thr Pro Leu Ser Pro Ser Leu Phe Pro Pro Ser Gln Thr Leu Pro 
        35                  40                  45              


Ser Leu Pro Leu Gly Pro Pro Ala His Met Ser Gly Ile Ser Ala Trp 
    50                  55                  60                  


Thr Gly Ser Ser Leu Pro Thr Glu Ala Ala Pro Gly Asp Leu Glu Gly 
65                  70                  75                  80  


Phe Lys Leu Gly Gly Ser Asp Thr Trp Gly Pro Gln Tyr Asp Glu Leu 
                85                  90                  95      


Pro His Tyr Pro Gly Ile Val Asp Gly Pro Ala Ala Leu Ala Ser Phe 
            100                 105                 110         


Pro Glu Thr Val Pro Ala Val Pro Gly Pro Tyr Gly Pro His Arg Pro 
        115                 120                 125             


Pro Gln Pro Leu Pro Pro Gly Leu Asp Ser Asp Gly Leu Lys Arg Glu 
    130                 135                 140                 


Lys Asp Glu Ile Tyr Gly His Pro Leu Phe Pro Leu Leu Ala Leu Val 
145                 150                 155                 160 


Phe Glu Lys Cys Glu Leu Ala Thr Cys Ser Pro Arg Asp Gly Ala Gly 
                165                 170                 175     


Ala Gly Leu Gly Thr Pro Pro Gly Gly Asp Val Cys Ser Ser Asp Ser 
            180                 185                 190         


Phe Asn Glu Asp Ile Ala Ala Phe Ala Lys Gln Val Arg Ser Glu Arg 
        195                 200                 205             


Pro Leu Phe Ser Ser Asn Pro Glu Leu Asp Asn Leu Met Ile Gln Ala 
    210                 215                 220                 


Ile Gln Val Leu Arg Phe His Leu Leu Glu Leu Glu Lys Val His Asp 
225                 230                 235                 240 


Leu Cys Asp Asn Phe Cys His Arg Tyr Ile Thr Cys Leu Lys Gly Lys 
                245                 250                 255     


Met Pro Ile Asp Leu Val Ile Glu Asp Arg Asp Gly Gly Cys Arg Glu 
            260                 265                 270         


Asp Phe Glu Asp Tyr Pro Ala Ser Cys Pro Ser Leu Pro Asp Gln Asn 
        275                 280                 285             


Asn Met Trp Ile Arg Asp His Glu Asp Ser Gly Ser Val His Leu Gly 
    290                 295                 300                 


Thr Pro Gly Pro Ser Ser Gly Gly Leu Ala Ser Gln Ser Gly Asp Asn 
305                 310                 315                 320 


Ser Ser Asp Gln Gly Asp Gly Leu Asp Thr Ser Val Ala Ser Pro Ser 
                325                 330                 335     


Ser Gly Gly Glu Asp Glu Asp Leu Asp Gln Glu Arg Arg Arg Asn Lys 
            340                 345                 350         


Lys Arg Gly Ile Phe Pro Lys Val Ala Thr Asn Ile Met Arg Ala Trp 
        355                 360                 365             


Leu Phe Gln His Leu Ser His Pro Tyr Pro Ser Glu Glu Gln Lys Lys 
    370                 375                 380                 


Gln Leu Ala Gln Asp Thr Gly Leu Thr Ile Leu Gln Val Asn Asn Trp 
385                 390                 395                 400 


Phe Ile Asn Ala Arg Arg Arg Ile Val Gln Pro Met Ile Asp Gln Ser 
                405                 410                 415     


Asn Arg Thr Gly Gln Gly Ala Ala Phe Ser Pro Glu Gly Gln Pro Ile 
            420                 425                 430         


Gly Gly Tyr Thr Glu Thr Gln Pro His Val Ala Val Arg Pro Pro Gly 
        435                 440                 445             


Ser Val Gly Met Ser Leu Asn Leu Glu Gly Glu Trp His Tyr Leu 
    450                 455                 460             


<210>  8533
<211>  250
<212>  PRT
<213>  Homo Sapiens

<400>  8533

Pro Pro Pro Ser Leu Ser Thr Pro Ala Leu Pro Pro Trp Val Ala Pro 
1               5                   10                  15      


Pro Ser Thr Pro Val Pro Pro Gln Val His Asp Leu Cys Asp Asn Phe 
            20                  25                  30          


Cys His Arg Tyr Ile Thr Cys Leu Lys Gly Lys Met Pro Ile Asp Leu 
        35                  40                  45              


Val Ile Glu Asp Arg Asp Gly Gly Cys Arg Glu Asp Phe Glu Asp Tyr 
    50                  55                  60                  


Pro Ala Ser Cys Pro Ser Leu Pro Asp Gln Asn Asn Met Trp Ile Arg 
65                  70                  75                  80  


Asp His Glu Asp Ser Gly Ser Val His Leu Gly Thr Pro Gly Pro Ser 
                85                  90                  95      


Ser Gly Gly Leu Ala Ser Gln Ser Gly Asp Asn Ser Ser Asp Gln Gly 
            100                 105                 110         


Asp Gly Leu Asp Thr Ser Val Ala Ser Pro Ser Ser Gly Gly Glu Asp 
        115                 120                 125             


Glu Asp Leu Asp Gln Glu Arg Arg Arg Asn Lys Lys Arg Gly Ile Phe 
    130                 135                 140                 


Pro Lys Val Ala Thr Asn Ile Met Arg Ala Trp Leu Phe Gln His Leu 
145                 150                 155                 160 


Ser His Pro Tyr Pro Ser Glu Glu Gln Lys Lys Gln Leu Ala Gln Asp 
                165                 170                 175     


Thr Gly Leu Thr Ile Leu Gln Val Asn Asn Trp Phe Ile Asn Ala Arg 
            180                 185                 190         


Arg Arg Ile Val Gln Pro Met Ile Asp Gln Ser Asn Arg Thr Gly Gln 
        195                 200                 205             


Gly Ala Ala Phe Ser Pro Glu Gly Gln Pro Ile Gly Gly Tyr Thr Glu 
    210                 215                 220                 


Thr Gln Pro His Val Ala Val Arg Pro Pro Gly Ser Val Gly Met Ser 
225                 230                 235                 240 


Leu Asn Leu Glu Gly Glu Trp His Tyr Leu 
                245                 250 


<210>  8534
<211>  178
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8534

Xaa Gly Leu Ser Leu Pro Ser Gln Val Arg Ser Glu Arg Pro Leu Phe 
1               5                   10                  15      


Ser Ser Asn Pro Glu Leu Asp Asn Leu Gly Lys Met Pro Ile Asp Leu 
            20                  25                  30          


Val Ile Glu Asp Arg Asp Gly Gly Cys Arg Glu Asp Phe Glu Asp Tyr 
        35                  40                  45              


Pro Ala Ser Cys Pro Ser Leu Pro Asp Gln Asn Asn Met Trp Ile Arg 
    50                  55                  60                  


Asp His Glu Asp Ser Gly Ser Val His Leu Gly Thr Pro Gly Pro Ser 
65                  70                  75                  80  


Ser Gly Gly Leu Ala Ser Gln Ser Gly Asp Asn Ser Ser Asp Gln Gly 
                85                  90                  95      


Asp Gly Leu Asp Thr Ser Val Ala Ser Pro Ser Ser Gly Gly Glu Asp 
            100                 105                 110         


Glu Asp Leu Asp Gln Glu Arg Arg Arg Asn Lys Lys Arg Gly Ile Phe 
        115                 120                 125             


Pro Lys Val Ala Thr Asn Ile Met Arg Ala Trp Leu Phe Gln His Leu 
    130                 135                 140                 


Ser Arg Arg Ser Glu Ala Pro Val Leu Pro Asp Val Cys Leu Gly Leu 
145                 150                 155                 160 


Gly Ser Pro Ser Pro Gly Pro Arg Trp Ala Arg Pro Trp Gly Ser Asp 
                165                 170                 175     


Cys Gly 
        


<210>  8535
<211>  302
<212>  PRT
<213>  Homo Sapiens

<400>  8535

Met Arg Gly Pro Ser Gly Ala Leu Trp Leu Leu Leu Ala Leu Arg Thr 
1               5                   10                  15      


Val Leu Gly Gly Met Glu Val Arg Trp Cys Ala Thr Ser Asp Pro Glu 
            20                  25                  30          


Gln His Lys Cys Gly Asn Met Ser Glu Ala Phe Arg Glu Ala Gly Ile 
        35                  40                  45              


Gln Pro Ser Leu Leu Cys Val Arg Gly Thr Ser Ala Asp His Cys Val 
    50                  55                  60                  


Gln Leu Ile Ala Ala Gln Glu Ala Asp Ala Ile Thr Leu Asp Gly Gly 
65                  70                  75                  80  


Ala Ile Tyr Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val Val Gly 
                85                  90                  95      


Glu Val Tyr Asp Gln Glu Val Gly Thr Ser Tyr Tyr Ala Val Ala Val 
            100                 105                 110         


Val Arg Arg Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys 
        115                 120                 125             


Ser Cys His Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val Pro Val 
    130                 135                 140                 


Gly Tyr Leu Val Glu Ser Gly Arg Leu Ser Val Met Gly Cys Asp Val 
145                 150                 155                 160 


Leu Lys Ala Val Ser Asp Tyr Phe Gly Gly Ser Cys Val Pro Gly Ala 
                165                 170                 175     


Gly Glu Thr Ser Tyr Ser Glu Ser Leu Cys Arg Leu Cys Arg Gly Asp 
            180                 185                 190         


Ser Ser Gly Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg Tyr Tyr 
        195                 200                 205             


Asp Tyr Ser Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val 
    210                 215                 220                 


Ala Phe Val Lys His Ser Thr Val Leu Glu Asn Thr Asp Glu Ser Pro 
225                 230                 235                 240 


Ser Arg Arg Gln Thr Trp Thr Arg Ser Glu Glu Glu Glu Gly Glu Cys 
                245                 250                 255     


Pro Ala His Glu Glu Ala Arg Arg Thr Met Arg Ser Ser Ala Gly Gln 
            260                 265                 270         


Ala Trp Lys Trp Ala Pro Val His Arg Pro Gln Asp Glu Ser Asp Lys 
        275                 280                 285             


Gly Glu Phe Gly Lys Arg Ala Lys Ser Arg Asp Met Leu Gly 
    290                 295                 300         


<210>  8536
<211>  738
<212>  PRT
<213>  Homo Sapiens

<400>  8536

Met Arg Gly Pro Ser Gly Ala Leu Trp Leu Leu Leu Ala Leu Arg Thr 
1               5                   10                  15      


Val Leu Gly Gly Met Glu Val Arg Trp Cys Ala Thr Ser Asp Pro Glu 
            20                  25                  30          


Gln His Lys Cys Gly Asn Met Ser Glu Ala Phe Arg Glu Ala Gly Ile 
        35                  40                  45              


Gln Pro Ser Leu Leu Cys Val Arg Gly Thr Ser Ala Asp His Cys Val 
    50                  55                  60                  


Gln Leu Ile Ala Ala Gln Glu Ala Asp Ala Ile Thr Leu Asp Gly Gly 
65                  70                  75                  80  


Ala Ile Tyr Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val Val Gly 
                85                  90                  95      


Glu Val Tyr Asp Gln Glu Val Gly Thr Ser Tyr Tyr Ala Val Ala Val 
            100                 105                 110         


Val Arg Arg Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys 
        115                 120                 125             


Ser Cys His Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val Pro Val 
    130                 135                 140                 


Gly Tyr Leu Val Glu Ser Gly Arg Leu Ser Val Met Gly Cys Asp Val 
145                 150                 155                 160 


Leu Lys Ala Val Ser Asp Tyr Phe Gly Gly Ser Cys Val Pro Gly Ala 
                165                 170                 175     


Gly Glu Thr Ser Tyr Ser Glu Ser Leu Cys Arg Leu Cys Arg Gly Asp 
            180                 185                 190         


Ser Ser Gly Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg Tyr Tyr 
        195                 200                 205             


Asp Tyr Ser Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val 
    210                 215                 220                 


Ala Phe Val Lys His Ser Thr Val Leu Glu Asn Thr Asp Gly Lys Thr 
225                 230                 235                 240 


Leu Pro Ser Trp Gly Gln Ala Leu Leu Ser Gln Asp Phe Glu Leu Leu 
                245                 250                 255     


Cys Arg Asp Gly Ser Arg Ala Asp Val Thr Glu Trp Arg Gln Cys His 
            260                 265                 270         


Leu Ala Arg Val Pro Ala His Ala Val Val Val Arg Ala Asp Thr Asp 
        275                 280                 285             


Gly Gly Leu Ile Phe Arg Leu Leu Asn Glu Gly Gln Arg Leu Phe Ser 
    290                 295                 300                 


His Glu Gly Ser Ser Phe Gln Met Phe Ser Ser Glu Ala Tyr Gly Gln 
305                 310                 315                 320 


Lys Asp Leu Leu Phe Lys Asp Ser Thr Ser Glu Leu Val Pro Ile Ala 
                325                 330                 335     


Thr Gln Thr Tyr Glu Ala Trp Leu Gly His Glu Tyr Leu His Ala Met 
            340                 345                 350         


Lys Gly Leu Leu Cys Asp Pro Asn Arg Leu Pro Pro Tyr Leu Arg Trp 
        355                 360                 365             


Cys Val Leu Ser Thr Pro Glu Ile Gln Lys Cys Gly Asp Met Ala Val 
    370                 375                 380                 


Ala Phe Arg Arg Gln Arg Leu Lys Pro Glu Ile Gln Cys Val Ser Ala 
385                 390                 395                 400 


Lys Ser Pro Gln His Cys Met Glu Arg Ile Gln Ala Glu Gln Val Asp 
                405                 410                 415     


Ala Val Thr Leu Ser Gly Glu Asp Ile Tyr Thr Ala Gly Lys Thr Tyr 
            420                 425                 430         


Gly Leu Val Pro Ala Ala Gly Glu His Tyr Ala Pro Glu Asp Ser Ser 
        435                 440                 445             


Asn Ser Tyr Tyr Val Val Ala Val Val Arg Arg Asp Ser Ser His Ala 
    450                 455                 460                 


Phe Thr Leu Asp Glu Leu Arg Gly Lys Arg Ser Cys His Ala Gly Phe 
465                 470                 475                 480 


Gly Ser Pro Ala Gly Trp Asp Val Pro Val Gly Ala Leu Ile Gln Arg 
                485                 490                 495     


Gly Phe Ile Arg Pro Lys Asp Cys Asp Val Leu Thr Ala Val Ser Glu 
            500                 505                 510         


Phe Phe Asn Ala Ser Cys Val Pro Val Asn Asn Pro Lys Asn Tyr Pro 
        515                 520                 525             


Ser Ser Leu Cys Ala Leu Cys Val Gly Asp Glu Gln Gly Arg Asn Lys 
    530                 535                 540                 


Cys Val Gly Asn Ser Gln Glu Arg Tyr Tyr Gly Tyr Arg Gly Ala Phe 
545                 550                 555                 560 


Arg Cys Leu Val Glu Asn Ala Gly Asp Val Ala Phe Val Arg His Thr 
                565                 570                 575     


Thr Val Phe Asp Asn Thr Asn Gly His Asn Ser Glu Pro Trp Ala Ala 
            580                 585                 590         


Glu Leu Arg Ser Glu Asp Tyr Glu Leu Leu Cys Pro Asn Gly Ala Arg 
        595                 600                 605             


Ala Glu Val Ser Gln Phe Ala Ala Cys Asn Leu Ala Gln Ile Pro Pro 
    610                 615                 620                 


His Ala Val Met Val Arg Pro Asp Thr Asn Ile Phe Thr Val Tyr Gly 
625                 630                 635                 640 


Leu Leu Asp Lys Ala Gln Asp Leu Phe Gly Asp Asp His Asn Lys Asn 
                645                 650                 655     


Gly Phe Lys Met Phe Asp Ser Ser Asn Tyr His Gly Gln Asp Leu Leu 
            660                 665                 670         


Phe Lys Asp Ala Thr Val Arg Ala Val Pro Val Gly Glu Lys Thr Thr 
        675                 680                 685             


Tyr Arg Gly Trp Leu Gly Leu Asp Tyr Val Ala Ala Leu Glu Gly Met 
    690                 695                 700                 


Ser Ser Gln Gln Cys Ser Gly Ala Ala Ala Pro Ala Pro Gly Ala Pro 
705                 710                 715                 720 


Leu Leu Pro Leu Leu Leu Pro Ala Leu Ala Ala Arg Leu Leu Pro Pro 
                725                 730                 735     


Ala Leu 
        


<210>  8537
<211>  181
<212>  PRT
<213>  Homo Sapiens

<400>  8537

Met Arg Gly Pro Ser Gly Ala Leu Trp Leu Leu Leu Ala Leu Arg Thr 
1               5                   10                  15      


Val Leu Gly Gly Met Glu Val Arg Trp Cys Ala Thr Ser Asp Pro Glu 
            20                  25                  30          


Gln His Lys Cys Gly Asn Met Ser Glu Ala Phe Arg Glu Ala Gly Ile 
        35                  40                  45              


Gln Pro Ser Leu Leu Cys Val Arg Gly Thr Ser Ala Asp His Cys Val 
    50                  55                  60                  


Gln Leu Ile Ala Ala Gln Glu Ala Asp Ala Ile Thr Leu Asp Gly Gly 
65                  70                  75                  80  


Ala Ile Tyr Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val Val Gly 
                85                  90                  95      


Glu Val Tyr Asp Gln Glu Val Gly Thr Ser Tyr Tyr Ala Val Ala Val 
            100                 105                 110         


Val Arg Arg Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys 
        115                 120                 125             


Ser Cys His Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val Pro Val 
    130                 135                 140                 


Gly Tyr Leu Val Glu Ser Gly Arg Leu Ser Val Met Gly Cys Asp Val 
145                 150                 155                 160 


Leu Lys Gly Pro Lys Arg Gly Ala Asp Leu His Pro Glu Ser Ser Gln 
                165                 170                 175     


Val Ala His Gln Pro 
            180     


<210>  8538
<211>  96
<212>  PRT
<213>  Homo Sapiens

<400>  8538

Met Arg Val Phe Cys Val Gly Leu Leu Leu Phe Ser Val Thr Trp Ala 
1               5                   10                  15      


Ala Pro Thr Phe Gln Pro Gln Thr Glu Lys Thr Lys Gln Ser Cys Val 
            20                  25                  30          


Glu Glu Gln Arg Ala Pro Gln Ala Ser Leu Leu Gln Asn Ser Gly Ser 
        35                  40                  45              


Gln Asn Leu Pro Asp Pro His Pro Met Pro Arg Pro Thr Ser Arg Ser 
    50                  55                  60                  


Ala Ser Gly Pro Val Ala Ala Gly Val Ile Leu Met Asp Leu Ser Arg 
65                  70                  75                  80  


Lys Lys Lys Thr Lys Thr Ile Leu Val Phe Thr Ile Trp Ala Arg Glu 
                85                  90                  95      


<210>  8539
<211>  556
<212>  PRT
<213>  Homo Sapiens

<400>  8539

Met Arg Val Phe Cys Val Gly Leu Leu Leu Phe Ser Val Thr Trp Ala 
1               5                   10                  15      


Ala Pro Thr Phe Gln Pro Gln Thr Glu Lys Thr Lys Gln Ser Cys Val 
            20                  25                  30          


Glu Glu Gln Arg Ile Thr Tyr Lys Gly His Tyr Glu Lys His Gly His 
        35                  40                  45              


Tyr Val Phe Lys Cys Val Tyr Met Ser Pro Glu Lys Lys Asn Gln Thr 
    50                  55                  60                  


Asp Val Lys Gln Glu Glu Lys Asn Lys Asp Asn Ile Gly Phe His His 
65                  70                  75                  80  


Leu Gly Lys Arg Ile Asn Gln Glu Leu Ser Ser Lys Glu Asn Ile Val 
                85                  90                  95      


Gln Glu Arg Lys Lys Asp Leu Ser Leu Ser Glu Ala Ser Glu Asn Lys 
            100                 105                 110         


Gly Ser Ser Lys Ser Gln Asn Tyr Phe Thr Asn Arg Gln Arg Leu Asn 
        115                 120                 125             


Lys Glu Tyr Ser Ile Ser Asn Lys Glu Asn Thr His Asn Gly Leu Arg 
    130                 135                 140                 


Met Ser Ile Tyr Pro Lys Ser Thr Gly Asn Lys Gly Phe Glu Asp Gly 
145                 150                 155                 160 


Asp Asp Ala Ile Ser Lys Leu His Asp Gln Glu Glu Tyr Gly Ala Ala 
                165                 170                 175     


Leu Ile Arg Asn Asn Met Gln His Ile Met Gly Pro Val Thr Ala Ile 
            180                 185                 190         


Lys Leu Leu Gly Glu Glu Asn Lys Glu Asn Thr Pro Arg Asn Val Leu 
        195                 200                 205             


Asn Ile Ile Pro Ala Ser Met Asn Tyr Ala Lys Ala His Ser Lys Asp 
    210                 215                 220                 


Lys Lys Lys Pro Gln Arg Asp Ser Gln Ala Gln Lys Ser Pro Val Lys 
225                 230                 235                 240 


Ser Lys Ser Thr His Arg Ile Gln His Asn Ile Asp Tyr Leu Lys His 
                245                 250                 255     


Leu Ser Lys Val Lys Lys Ile Pro Ser Asp Phe Glu Gly Ser Gly Tyr 
            260                 265                 270         


Thr Asp Leu Gln Glu Arg Gly Asp Asn Asp Ile Ser Pro Phe Ser Gly 
        275                 280                 285             


Asp Gly Gln Pro Phe Lys Asp Ile Pro Gly Lys Gly Glu Ala Thr Gly 
    290                 295                 300                 


Pro Asp Leu Glu Gly Lys Asp Ile Gln Thr Gly Phe Ala Gly Pro Ser 
305                 310                 315                 320 


Glu Ala Glu Ser Thr His Leu Asp Thr Lys Lys Pro Gly Tyr Asn Glu 
                325                 330                 335     


Ile Pro Glu Arg Glu Glu Asn Gly Gly Asn Thr Ile Gly Thr Arg Asp 
            340                 345                 350         


Glu Thr Ala Lys Glu Ala Asp Ala Val Asp Val Ser Leu Val Glu Gly 
        355                 360                 365             


Ser Asn Asp Ile Met Gly Ser Thr Asn Phe Lys Glu Leu Pro Gly Arg 
    370                 375                 380                 


Glu Gly Asn Arg Val Asp Ala Gly Ser Gln Asn Ala His Gln Gly Lys 
385                 390                 395                 400 


Val Glu Phe His Tyr Pro Pro Ala Pro Ser Lys Glu Lys Arg Lys Glu 
                405                 410                 415     


Gly Ser Ser Asp Ala Ala Glu Ser Thr Asn Tyr Asn Glu Ile Pro Lys 
            420                 425                 430         


Asn Gly Lys Gly Ser Thr Arg Lys Gly Val Asp His Ser Asn Arg Asn 
        435                 440                 445             


Gln Ala Thr Leu Asn Glu Lys Gln Arg Phe Pro Ser Lys Gly Lys Ser 
    450                 455                 460                 


Gln Gly Leu Pro Ile Pro Ser Arg Gly Leu Asp Asn Glu Ile Lys Asn 
465                 470                 475                 480 


Glu Met Asp Ser Phe Asn Gly Pro Ser His Glu Asn Ile Ile Thr His 
                485                 490                 495     


Gly Arg Lys Tyr His Tyr Val Pro His Arg Gln Asn Asn Ser Thr Arg 
            500                 505                 510         


Asn Lys Gly Met Pro Gln Gly Lys Gly Ser Trp Gly Arg Gln Pro His 
        515                 520                 525             


Ser Asn Arg Arg Phe Ser Ser Arg Arg Arg Asp Asp Ser Ser Glu Ser 
    530                 535                 540                 


Ser Asp Ser Gly Ser Ser Ser Glu Ser Asp Gly Asp 
545                 550                 555     


<210>  8540
<211>  525
<212>  PRT
<213>  Homo Sapiens

<400>  8540

Met Arg Val Phe Cys Val Gly Leu Leu Leu Phe Ser Val Thr Trp Ala 
1               5                   10                  15      


Ala Pro Thr Phe Gln Pro Gln Thr Glu Lys Thr Lys Gln Ser Cys Val 
            20                  25                  30          


Glu Glu Gln Arg Gln Glu Glu Lys Asn Lys Asp Asn Ile Gly Phe His 
        35                  40                  45              


His Leu Gly Lys Arg Ile Asn Gln Glu Leu Ser Ser Lys Glu Asn Ile 
    50                  55                  60                  


Val Gln Glu Arg Lys Lys Asp Leu Ser Leu Ser Glu Ala Ser Glu Asn 
65                  70                  75                  80  


Lys Gly Ser Ser Lys Ser Gln Asn Tyr Phe Thr Asn Arg Gln Arg Leu 
                85                  90                  95      


Asn Lys Glu Tyr Ser Ile Ser Asn Lys Glu Asn Thr His Asn Gly Leu 
            100                 105                 110         


Arg Met Ser Ile Tyr Pro Lys Ser Thr Gly Asn Lys Gly Phe Glu Asp 
        115                 120                 125             


Gly Asp Asp Ala Ile Ser Lys Leu His Asp Gln Glu Glu Tyr Gly Ala 
    130                 135                 140                 


Ala Leu Ile Arg Asn Asn Met Gln His Ile Met Gly Pro Val Thr Ala 
145                 150                 155                 160 


Ile Lys Leu Leu Gly Glu Glu Asn Lys Glu Asn Thr Pro Arg Asn Val 
                165                 170                 175     


Leu Asn Ile Ile Pro Ala Ser Met Asn Tyr Ala Lys Ala His Ser Lys 
            180                 185                 190         


Asp Lys Lys Lys Pro Gln Arg Asp Ser Gln Ala Gln Lys Ser Pro Val 
        195                 200                 205             


Lys Ser Lys Ser Thr His Arg Ile Gln His Asn Ile Asp Tyr Leu Lys 
    210                 215                 220                 


His Leu Ser Lys Val Lys Lys Ile Pro Ser Asp Phe Glu Gly Ser Gly 
225                 230                 235                 240 


Tyr Thr Asp Leu Gln Glu Arg Gly Asp Asn Asp Ile Ser Pro Phe Ser 
                245                 250                 255     


Gly Asp Gly Gln Pro Phe Lys Asp Ile Pro Gly Lys Gly Glu Ala Thr 
            260                 265                 270         


Gly Pro Asp Leu Glu Gly Lys Asp Ile Gln Thr Gly Phe Ala Gly Pro 
        275                 280                 285             


Ser Glu Ala Glu Ser Thr His Leu Asp Thr Lys Lys Pro Gly Tyr Asn 
    290                 295                 300                 


Glu Ile Pro Glu Arg Glu Glu Asn Gly Gly Asn Thr Ile Gly Thr Arg 
305                 310                 315                 320 


Asp Glu Thr Ala Lys Glu Ala Asp Ala Val Asp Val Ser Leu Val Glu 
                325                 330                 335     


Gly Ser Asn Asp Ile Met Gly Ser Thr Asn Phe Lys Glu Leu Pro Gly 
            340                 345                 350         


Arg Glu Gly Asn Arg Val Asp Ala Gly Ser Gln Asn Ala His Gln Gly 
        355                 360                 365             


Lys Val Glu Phe His Tyr Pro Pro Ala Pro Ser Lys Glu Lys Arg Lys 
    370                 375                 380                 


Glu Gly Ser Ser Asp Ala Ala Glu Ser Thr Asn Tyr Asn Glu Ile Pro 
385                 390                 395                 400 


Lys Asn Gly Lys Gly Ser Thr Arg Lys Gly Val Asp His Ser Asn Arg 
                405                 410                 415     


Asn Gln Ala Thr Leu Asn Glu Lys Gln Arg Phe Pro Ser Lys Gly Lys 
            420                 425                 430         


Ser Gln Gly Leu Pro Ile Pro Ser Arg Gly Leu Asp Asn Glu Ile Lys 
        435                 440                 445             


Asn Glu Met Asp Ser Phe Asn Gly Pro Ser His Glu Asn Ile Ile Thr 
    450                 455                 460                 


His Gly Arg Lys Tyr His Tyr Val Pro His Arg Gln Asn Asn Ser Thr 
465                 470                 475                 480 


Arg Asn Lys Gly Met Pro Gln Gly Lys Gly Ser Trp Gly Arg Gln Pro 
                485                 490                 495     


His Ser Asn Arg Arg Phe Ser Ser Arg Arg Arg Asp Asp Ser Ser Glu 
            500                 505                 510         


Ser Ser Asp Ser Gly Ser Ser Ser Glu Ser Asp Gly Asp 
        515                 520                 525 


<210>  8541
<211>  525
<212>  PRT
<213>  Homo Sapiens

<400>  8541

Met Arg Val Phe Cys Val Gly Leu Leu Leu Phe Ser Val Thr Trp Ala 
1               5                   10                  15      


Ala Pro Thr Phe Gln Pro Gln Thr Glu Lys Thr Lys Gln Ser Cys Val 
            20                  25                  30          


Glu Glu Gln Arg Gln Glu Glu Lys Asn Lys Asp Asn Ile Gly Phe His 
        35                  40                  45              


His Leu Gly Lys Arg Ile Asn Gln Glu Leu Ser Ser Lys Glu Asn Ile 
    50                  55                  60                  


Val Gln Glu Arg Lys Lys Asp Leu Ser Leu Ser Glu Ala Ser Glu Asn 
65                  70                  75                  80  


Lys Gly Ser Ser Lys Ser Gln Asn Tyr Phe Thr Asn Arg Gln Arg Leu 
                85                  90                  95      


Asn Lys Glu Tyr Ser Ile Ser Asn Lys Glu Asn Thr His Asn Gly Leu 
            100                 105                 110         


Arg Met Ser Ile Tyr Pro Lys Ser Thr Gly Asn Lys Gly Phe Glu Asp 
        115                 120                 125             


Gly Asp Asp Ala Ile Ser Lys Leu His Asp Gln Glu Glu Tyr Gly Ala 
    130                 135                 140                 


Ala Leu Ile Arg Asn Asn Met Gln His Ile Met Gly Pro Val Thr Ala 
145                 150                 155                 160 


Ile Lys Leu Leu Gly Glu Glu Asn Lys Glu Asn Thr Pro Arg Asn Val 
                165                 170                 175     


Leu Asn Ile Ile Pro Ala Ser Met Asn Tyr Ala Lys Ala His Ser Lys 
            180                 185                 190         


Asp Lys Lys Lys Pro Gln Arg Asp Ser Gln Ala Gln Lys Ser Pro Val 
        195                 200                 205             


Lys Ser Lys Ser Thr His Arg Ile Gln His Asn Ile Asp Tyr Leu Lys 
    210                 215                 220                 


His Leu Ser Lys Val Lys Lys Ile Pro Ser Asp Phe Glu Gly Ser Gly 
225                 230                 235                 240 


Tyr Thr Asp Leu Gln Glu Arg Gly Asp Asn Asp Ile Ser Pro Phe Ser 
                245                 250                 255     


Gly Asp Gly Gln Pro Phe Lys Asp Ile Pro Gly Lys Gly Glu Ala Thr 
            260                 265                 270         


Gly Pro Asp Leu Glu Gly Lys Asp Ile Gln Thr Gly Phe Ala Gly Pro 
        275                 280                 285             


Ser Glu Ala Glu Ser Thr His Leu Asp Thr Lys Lys Pro Gly Tyr Asn 
    290                 295                 300                 


Glu Ile Pro Glu Arg Glu Glu Asn Gly Gly Asn Thr Ile Gly Thr Arg 
305                 310                 315                 320 


Asp Glu Thr Ala Lys Glu Ala Asp Ala Val Asp Val Ser Leu Val Glu 
                325                 330                 335     


Gly Ser Asn Asp Ile Met Gly Ser Thr Asn Phe Lys Glu Leu Pro Gly 
            340                 345                 350         


Arg Glu Gly Asn Arg Val Asp Ala Gly Ser Gln Asn Ala His Gln Gly 
        355                 360                 365             


Lys Val Glu Phe His Tyr Pro Pro Ala Pro Ser Lys Glu Lys Arg Lys 
    370                 375                 380                 


Glu Gly Ser Ser Asp Ala Ala Glu Ser Thr Asn Tyr Asn Glu Ile Pro 
385                 390                 395                 400 


Lys Asn Gly Lys Gly Ser Thr Arg Lys Gly Val Asp His Ser Asn Arg 
                405                 410                 415     


Asn Gln Ala Thr Leu Asn Glu Lys Gln Arg Phe Pro Ser Lys Gly Lys 
            420                 425                 430         


Ser Gln Gly Leu Pro Ile Pro Ser Arg Gly Leu Asp Asn Glu Ile Lys 
        435                 440                 445             


Asn Glu Met Asp Ser Phe Asn Gly Pro Ser His Glu Asn Ile Ile Thr 
    450                 455                 460                 


His Gly Arg Lys Tyr His Tyr Val Pro His Arg Gln Asn Asn Ser Thr 
465                 470                 475                 480 


Arg Asn Lys Gly Met Pro Gln Gly Lys Gly Ser Trp Gly Arg Gln Pro 
                485                 490                 495     


His Ser Asn Arg Arg Phe Ser Ser Arg Arg Arg Asp Asp Ser Ser Glu 
            500                 505                 510         


Ser Ser Asp Ser Gly Ser Ser Ser Glu Ser Asp Gly Asp 
        515                 520                 525 


<210>  8542
<211>  412
<212>  PRT
<213>  Homo Sapiens

<400>  8542

Met Ser Ile Tyr Pro Lys Ser Thr Gly Asn Lys Gly Phe Glu Asp Gly 
1               5                   10                  15      


Asp Asp Ala Ile Ser Lys Leu His Asp Gln Glu Glu Tyr Gly Ala Ala 
            20                  25                  30          


Leu Ile Arg Asn Asn Met Gln His Ile Met Gly Pro Val Thr Ala Ile 
        35                  40                  45              


Lys Leu Leu Gly Glu Glu Asn Lys Glu Asn Thr Pro Arg Asn Val Leu 
    50                  55                  60                  


Asn Ile Ile Pro Ala Ser Met Asn Tyr Ala Lys Ala His Ser Lys Asp 
65                  70                  75                  80  


Lys Lys Lys Pro Gln Arg Asp Ser Gln Ala Gln Lys Ser Pro Val Lys 
                85                  90                  95      


Ser Lys Ser Thr His Arg Ile Gln His Asn Ile Asp Tyr Leu Lys His 
            100                 105                 110         


Leu Ser Lys Val Lys Lys Ile Pro Ser Asp Phe Glu Gly Ser Gly Tyr 
        115                 120                 125             


Thr Asp Leu Gln Glu Arg Gly Asp Asn Asp Ile Ser Pro Phe Ser Gly 
    130                 135                 140                 


Asp Gly Gln Pro Phe Lys Asp Ile Pro Gly Lys Gly Glu Ala Thr Gly 
145                 150                 155                 160 


Pro Asp Leu Glu Gly Lys Asp Ile Gln Thr Gly Phe Ala Gly Pro Ser 
                165                 170                 175     


Glu Ala Glu Ser Thr His Leu Asp Thr Lys Lys Pro Gly Tyr Asn Glu 
            180                 185                 190         


Ile Pro Glu Arg Glu Glu Asn Gly Gly Asn Thr Ile Gly Thr Arg Asp 
        195                 200                 205             


Glu Thr Ala Lys Glu Ala Asp Ala Val Asp Val Ser Leu Val Glu Gly 
    210                 215                 220                 


Ser Asn Asp Ile Met Gly Ser Thr Asn Phe Lys Glu Leu Pro Gly Arg 
225                 230                 235                 240 


Glu Gly Asn Arg Val Asp Ala Gly Ser Gln Asn Ala His Gln Gly Lys 
                245                 250                 255     


Val Glu Phe His Tyr Pro Pro Ala Pro Ser Lys Glu Lys Arg Lys Glu 
            260                 265                 270         


Gly Ser Ser Asp Ala Ala Glu Ser Thr Asn Tyr Asn Glu Ile Pro Lys 
        275                 280                 285             


Asn Gly Lys Gly Ser Thr Arg Lys Gly Val Asp His Ser Asn Arg Asn 
    290                 295                 300                 


Gln Ala Thr Leu Asn Glu Lys Gln Arg Phe Pro Ser Lys Gly Lys Ser 
305                 310                 315                 320 


Gln Gly Leu Pro Ile Pro Ser Arg Gly Leu Asp Asn Glu Ile Lys Asn 
                325                 330                 335     


Glu Met Asp Ser Phe Asn Gly Pro Ser His Glu Asn Ile Ile Thr His 
            340                 345                 350         


Gly Arg Lys Tyr His Tyr Val Pro His Arg Gln Asn Asn Ser Thr Arg 
        355                 360                 365             


Asn Lys Gly Met Pro Gln Gly Lys Gly Ser Trp Gly Arg Gln Pro His 
    370                 375                 380                 


Ser Asn Arg Arg Phe Ser Ser Arg Arg Arg Asp Asp Ser Ser Glu Ser 
385                 390                 395                 400 


Ser Asp Ser Gly Ser Ser Ser Glu Ser Asp Gly Asp 
                405                 410         


<210>  8543
<211>  412
<212>  PRT
<213>  Homo Sapiens

<400>  8543

Met Ser Ile Tyr Pro Lys Ser Thr Gly Asn Lys Gly Phe Glu Asp Gly 
1               5                   10                  15      


Asp Asp Ala Ile Ser Lys Leu His Asp Gln Glu Glu Tyr Gly Ala Ala 
            20                  25                  30          


Leu Ile Arg Asn Asn Met Gln His Ile Met Gly Pro Val Thr Ala Ile 
        35                  40                  45              


Lys Leu Leu Gly Glu Glu Asn Lys Glu Asn Thr Pro Arg Asn Val Leu 
    50                  55                  60                  


Asn Ile Ile Pro Ala Ser Met Asn Tyr Ala Lys Ala His Ser Lys Asp 
65                  70                  75                  80  


Lys Lys Lys Pro Gln Arg Asp Ser Gln Ala Gln Lys Ser Pro Val Lys 
                85                  90                  95      


Ser Lys Ser Thr His Arg Ile Gln His Asn Ile Asp Tyr Leu Lys His 
            100                 105                 110         


Leu Ser Lys Val Lys Lys Ile Pro Ser Asp Phe Glu Gly Ser Gly Tyr 
        115                 120                 125             


Thr Asp Leu Gln Glu Arg Gly Asp Asn Asp Ile Ser Pro Phe Ser Gly 
    130                 135                 140                 


Asp Gly Gln Pro Phe Lys Asp Ile Pro Gly Lys Gly Glu Ala Thr Gly 
145                 150                 155                 160 


Pro Asp Leu Glu Gly Lys Asp Ile Gln Thr Gly Phe Ala Gly Pro Ser 
                165                 170                 175     


Glu Ala Glu Ser Thr His Leu Asp Thr Lys Lys Pro Gly Tyr Asn Glu 
            180                 185                 190         


Ile Pro Glu Arg Glu Glu Asn Gly Gly Asn Thr Ile Gly Thr Arg Asp 
        195                 200                 205             


Glu Thr Ala Lys Glu Ala Asp Ala Val Asp Val Ser Leu Val Glu Gly 
    210                 215                 220                 


Ser Asn Asp Ile Met Gly Ser Thr Asn Phe Lys Glu Leu Pro Gly Arg 
225                 230                 235                 240 


Glu Gly Asn Arg Val Asp Ala Gly Ser Gln Asn Ala His Gln Gly Lys 
                245                 250                 255     


Val Glu Phe His Tyr Pro Pro Ala Pro Ser Lys Glu Lys Arg Lys Glu 
            260                 265                 270         


Gly Ser Ser Asp Ala Ala Glu Ser Thr Asn Tyr Asn Glu Ile Pro Lys 
        275                 280                 285             


Asn Gly Lys Gly Ser Thr Arg Lys Gly Val Asp His Ser Asn Arg Asn 
    290                 295                 300                 


Gln Ala Thr Leu Asn Glu Lys Gln Arg Phe Pro Ser Lys Gly Lys Ser 
305                 310                 315                 320 


Gln Gly Leu Pro Ile Pro Ser Arg Gly Leu Asp Asn Glu Ile Lys Asn 
                325                 330                 335     


Glu Met Asp Ser Phe Asn Gly Pro Ser His Glu Asn Ile Ile Thr His 
            340                 345                 350         


Gly Arg Lys Tyr His Tyr Val Pro His Arg Gln Asn Asn Ser Thr Arg 
        355                 360                 365             


Asn Lys Gly Met Pro Gln Gly Lys Gly Ser Trp Gly Arg Gln Pro His 
    370                 375                 380                 


Ser Asn Arg Arg Phe Ser Ser Arg Arg Arg Asp Asp Ser Ser Glu Ser 
385                 390                 395                 400 


Ser Asp Ser Gly Ser Ser Ser Glu Ser Asp Gly Asp 
                405                 410         


<210>  8544
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  8544

Met Ser Pro Glu Lys Lys Asn Gln Thr Asp Val Lys Gln Glu Glu Lys 
1               5                   10                  15      


Asn Lys Asp Asn Ile Gly Phe His His Leu Gly Lys Arg Ile Asn Gln 
            20                  25                  30          


Glu Leu Ser Ser Lys Glu Asn Ile Val Gln Glu Arg Lys Lys Asp Leu 
        35                  40                  45              


Ser Leu Ser Glu Ala Ser Glu Asn Lys Gly Ser Ser Lys Ser Gln Asn 
    50                  55                  60                  


Tyr Phe Thr Asn Arg Gln Arg Leu Asn Lys Glu Tyr Ser Ile Ser Asn 
65                  70                  75                  80  


Lys Glu Asn Thr His Asn Gly Leu Arg Met Ser Ile Tyr Pro Lys Ser 
                85                  90                  95      


Thr Gly Asn Lys Gly Phe Glu Asp Gly Asp Asp Ala Ile Ser Lys Leu 
            100                 105                 110         


His Asp Gln Glu Glu Tyr Gly Ala Ala Leu Ile Arg Asn Asn Met Gln 
        115                 120                 125             


His Ile Met Gly Pro Val Thr Ala Ile Lys Leu Leu Gly Glu Glu Asn 
    130                 135                 140                 


Lys Glu Asn Thr Pro Arg Asn Val Leu Asn Ile Ile Pro Ala Ser Met 
145                 150                 155                 160 


Asn Tyr Ala Lys Ala His Ser Lys Asp Lys Lys Lys Pro Gln Arg Asp 
                165                 170                 175     


Ser Gln Ala Gln Lys Ser Pro Val Lys Ser Lys Ser Thr His Arg Ile 
            180                 185                 190         


Gln His Asn Ile Asp Tyr Leu Lys His Leu Ser Lys Val Lys Lys Ile 
        195                 200                 205             


Pro Ser Asp Phe Glu Gly Ser Gly Tyr Thr Asp Leu Gln Glu Arg Gly 
    210                 215                 220                 


Asp Asn Asp Ile Ser Pro Phe Ser Gly Asp Gly Gln Pro Phe Lys Asp 
225                 230                 235                 240 


Ile Pro Gly Lys Gly Glu Ala Thr Gly Pro Asp Leu Glu Gly Lys Asp 
                245                 250                 255     


Ile Gln Thr Gly Phe Ala Gly Pro Ser Glu Ala Glu Ser Thr His Leu 
            260                 265                 270         


Asp Thr Lys Lys Pro Gly Tyr Asn Glu Ile Pro Glu Arg Glu Glu Asn 
        275                 280                 285             


Gly Gly Asn Thr Ile Gly Thr Arg Asp Glu Thr Ala Lys Glu Ala Asp 
    290                 295                 300                 


Ala Val Asp Val Ser Leu Val Glu Gly Ser Asn Asp Ile Met Gly Ser 
305                 310                 315                 320 


Thr Asn Phe Lys Glu Leu Pro Gly Arg Glu Gly Asn Arg Val Asp Ala 
                325                 330                 335     


Gly Ser Gln Asn Ala His Gln Gly Lys Val Glu Phe His Tyr Pro Pro 
            340                 345                 350         


Ala Pro Ser Lys Glu Lys Arg Lys Glu Gly Ser Ser Asp Ala Ala Glu 
        355                 360                 365             


Ser Thr Asn Tyr Asn Glu Ile Pro Lys Asn Gly Lys Gly Ser Thr Arg 
    370                 375                 380                 


Lys Gly Val Asp His Ser Asn Arg Asn Gln Ala Thr Leu Asn Glu Lys 
385                 390                 395                 400 


Gln Arg Phe Pro Ser Lys Gly Lys Ser Gln Gly Leu Pro Ile Pro Ser 
                405                 410                 415     


Arg Gly Leu Asp Asn Glu Ile Lys Asn Glu Met Asp Ser Phe Asn Gly 
            420                 425                 430         


Pro Ser His Glu Asn Ile Ile Thr His Gly Arg Lys Tyr His Tyr Val 
        435                 440                 445             


Pro His Arg Gln Asn Asn Ser Thr Arg Asn Lys Gly Met Pro Gln Gly 
    450                 455                 460                 


Lys Gly Ser Trp Gly Arg Gln Pro His Ser Asn Arg Arg Phe Ser Ser 
465                 470                 475                 480 


Arg Arg Arg Asp Asp Ser Ser Glu Ser Ser Asp Ser Gly Ser Ser Ser 
                485                 490                 495     


Glu Ser Asp Gly Asp 
            500     


<210>  8545
<211>  80
<212>  PRT
<213>  Homo Sapiens

<400>  8545

Met Ala Ala Ser Arg Trp Ala Arg Lys Ala Val Val Leu Leu Cys Ala 
1               5                   10                  15      


Ser Asp Leu Leu Leu Leu Leu Leu Leu Leu Pro Pro Pro Gly Ser Cys 
            20                  25                  30          


Ala Ala Glu Gly Ser Pro Gly Thr Pro Asp Glu Ser Thr Pro Pro Pro 
        35                  40                  45              


Arg Lys Lys Lys Lys Asp Ile Arg Asp Tyr Asn Asp Ala Asp Met Ala 
    50                  55                  60                  


Arg Leu Leu Glu Gln Trp Glu Ala Asn Thr Cys Pro Thr Ser Thr His 
65                  70                  75                  80  


<210>  8546
<211>  234
<212>  PRT
<213>  Homo Sapiens

<400>  8546

Met Ala Ala Ser Arg Trp Ala Arg Lys Ala Val Val Leu Leu Cys Ala 
1               5                   10                  15      


Ser Asp Leu Leu Leu Leu Leu Leu Leu Leu Pro Pro Pro Gly Ser Cys 
            20                  25                  30          


Ala Ala Glu Gly Ser Pro Gly Thr Pro Asp Glu Ser Thr Pro Pro Pro 
        35                  40                  45              


Arg Lys Lys Lys Lys Asp Ile Arg Asp Tyr Asn Asp Ala Asp Met Ala 
    50                  55                  60                  


Arg Leu Leu Glu Gln Trp Glu Lys Asp Asp Asp Ile Glu Glu Gly Asp 
65                  70                  75                  80  


Leu Pro Glu His Lys Arg Pro Ser Ala Pro Val Asp Phe Ser Lys Ile 
                85                  90                  95      


Asp Pro Ser Lys Pro Glu Ser Ile Leu Lys Met Thr Lys Lys Gly Lys 
            100                 105                 110         


Thr Leu Met Met Phe Val Thr Val Ser Gly Ser Pro Thr Glu Lys Glu 
        115                 120                 125             


Thr Glu Glu Ile Thr Ser Leu Trp Gln Gly Ser Leu Phe Asn Ala Asn 
    130                 135                 140                 


Tyr Asp Val Gln Arg Phe Ile Val Gly Ser Asp Arg Ala Ile Phe Met 
145                 150                 155                 160 


Leu Arg Asp Gly Ser Tyr Ala Trp Glu Ile Lys Asp Phe Leu Val Gly 
                165                 170                 175     


Gln Asp Arg Cys Ala Asp Val Thr Leu Glu Gly Gln Val Tyr Pro Gly 
            180                 185                 190         


Lys Gly Gly Gly Ser Lys Glu Lys Asn Lys Thr Lys Gln Asp Lys Gly 
        195                 200                 205             


Lys Lys Lys Lys Glu Gly Asp Leu Lys Ser Arg Ser Ser Lys Glu Glu 
    210                 215                 220                 


Asn Arg Ala Gly Asn Lys Arg Glu Asp Leu 
225                 230                 


<210>  8547
<211>  234
<212>  PRT
<213>  Homo Sapiens

<400>  8547

Met Ala Ala Ser Arg Trp Ala Arg Lys Ala Val Val Leu Leu Cys Ala 
1               5                   10                  15      


Ser Asp Leu Leu Leu Leu Leu Leu Leu Leu Pro Pro Pro Gly Ser Cys 
            20                  25                  30          


Ala Ala Glu Gly Ser Pro Gly Thr Pro Asp Glu Ser Thr Pro Pro Pro 
        35                  40                  45              


Arg Lys Lys Lys Lys Asp Ile Arg Asp Tyr Asn Asp Ala Asp Met Ala 
    50                  55                  60                  


Arg Leu Leu Glu Gln Trp Glu Lys Asp Asp Asp Ile Glu Glu Gly Asp 
65                  70                  75                  80  


Leu Pro Glu His Lys Arg Pro Ser Ala Pro Val Asp Phe Ser Lys Ile 
                85                  90                  95      


Asp Pro Ser Lys Pro Glu Ser Ile Leu Lys Met Thr Lys Lys Gly Lys 
            100                 105                 110         


Thr Leu Met Met Phe Val Thr Val Ser Gly Ser Pro Thr Glu Lys Glu 
        115                 120                 125             


Thr Glu Glu Ile Thr Ser Leu Trp Gln Gly Ser Leu Phe Asn Ala Asn 
    130                 135                 140                 


Tyr Asp Val Gln Arg Phe Ile Val Gly Ser Asp Arg Ala Ile Phe Met 
145                 150                 155                 160 


Leu Arg Asp Gly Ser Tyr Ala Trp Glu Ile Lys Asp Phe Leu Val Gly 
                165                 170                 175     


Gln Asp Arg Cys Ala Asp Val Thr Leu Glu Gly Gln Val Tyr Pro Gly 
            180                 185                 190         


Lys Gly Gly Gly Ser Lys Glu Lys Asn Lys Thr Lys Gln Asp Lys Gly 
        195                 200                 205             


Lys Lys Lys Lys Glu Gly Asp Leu Lys Ser Arg Ser Ser Lys Glu Glu 
    210                 215                 220                 


Asn Arg Ala Gly Asn Lys Arg Glu Asp Leu 
225                 230                 


<210>  8548
<211>  234
<212>  PRT
<213>  Homo Sapiens

<400>  8548

Met Ala Ala Ser Arg Trp Ala Arg Lys Ala Val Val Leu Leu Cys Ala 
1               5                   10                  15      


Ser Asp Leu Leu Leu Leu Leu Leu Leu Leu Pro Pro Pro Gly Ser Cys 
            20                  25                  30          


Ala Ala Glu Gly Ser Pro Gly Thr Pro Asp Glu Ser Thr Pro Pro Pro 
        35                  40                  45              


Arg Lys Lys Lys Lys Asp Ile Arg Asp Tyr Asn Asp Ala Asp Met Ala 
    50                  55                  60                  


Arg Leu Leu Glu Gln Trp Glu Lys Asp Asp Asp Ile Glu Glu Gly Asp 
65                  70                  75                  80  


Leu Pro Glu His Lys Arg Pro Ser Ala Pro Val Asp Phe Ser Lys Ile 
                85                  90                  95      


Asp Pro Ser Lys Pro Glu Ser Ile Leu Lys Met Thr Lys Lys Gly Lys 
            100                 105                 110         


Thr Leu Met Met Phe Val Thr Val Ser Gly Ser Pro Thr Glu Lys Glu 
        115                 120                 125             


Thr Glu Glu Ile Thr Ser Leu Trp Gln Gly Ser Leu Phe Asn Ala Asn 
    130                 135                 140                 


Tyr Asp Val Gln Arg Phe Ile Val Gly Ser Asp Arg Ala Ile Phe Met 
145                 150                 155                 160 


Leu Arg Asp Gly Ser Tyr Ala Trp Glu Ile Lys Asp Phe Leu Val Gly 
                165                 170                 175     


Gln Asp Arg Cys Ala Asp Val Thr Leu Glu Gly Gln Val Tyr Pro Gly 
            180                 185                 190         


Lys Gly Gly Gly Ser Lys Glu Lys Asn Lys Thr Lys Gln Asp Lys Gly 
        195                 200                 205             


Lys Lys Lys Lys Glu Gly Asp Leu Lys Ser Arg Ser Ser Lys Glu Glu 
    210                 215                 220                 


Asn Arg Ala Gly Asn Lys Arg Glu Asp Leu 
225                 230                 


<210>  8549
<211>  138
<212>  PRT
<213>  Homo Sapiens

<400>  8549

Met Ala Ala Ser Arg Trp Ala Arg Lys Ala Val Val Leu Leu Cys Ala 
1               5                   10                  15      


Ser Asp Leu Leu Leu Leu Leu Leu Leu Leu Pro Pro Pro Gly Ser Cys 
            20                  25                  30          


Ala Ala Glu Gly Ser Pro Gly Thr Pro Asp Glu Ser Thr Pro Pro Pro 
        35                  40                  45              


Arg Lys Lys Lys Lys Asp Ile Arg Asp Tyr Asn Asp Ala Asp Met Ala 
    50                  55                  60                  


Arg Leu Leu Glu Gln Trp Glu Thr Pro Glu Pro Leu Pro Val Leu Pro 
65                  70                  75                  80  


Glu Val Pro Ser Thr Cys Ala Cys Leu Ser Ser Ala Ser Leu Ile Trp 
                85                  90                  95      


Thr Cys Phe Ser His Leu Ser Pro His Ala Leu Val Lys Arg Val Trp 
            100                 105                 110         


Pro Pro Ala Lys Gln Gly Leu Gly Gly Lys Glu Ser Pro Ala Ser Ala 
        115                 120                 125             


Trp Leu Pro His Arg Gly Gly Glu Leu Lys 
    130                 135             


<210>  8550
<211>  173
<212>  PRT
<213>  Homo Sapiens

<400>  8550

Leu Leu Ser His Asp Tyr Gly Asp Ile Val Ala Gln Glu Leu Leu Tyr 
1               5                   10                  15      


Arg Tyr Lys Gln Asn Arg Ser Gly Arg Leu Thr Ile Lys Ser Leu Cys 
            20                  25                  30          


Leu Ser Asn Gly Gly Ile Phe Pro Glu Thr His Arg Pro Leu Leu Leu 
        35                  40                  45              


Gln Lys Leu Leu Lys Asp Gly Gly Val Leu Ser Pro Ile Leu Thr Arg 
    50                  55                  60                  


Leu Met Asn Phe Phe Leu Trp Asp Met Trp Ala Gly Ile Arg Asn Asn 
65                  70                  75                  80  


Asp Gly Asn Leu Val Ile Asp Ser Leu Leu Gln Tyr Ile Asn Gln Arg 
                85                  90                  95      


Lys Lys Phe Arg Arg Arg Trp Val Gly Ala Leu Ala Ser Val Thr Ile 
            100                 105                 110         


Pro Ile His Phe Ile Tyr Gly Pro Leu Asp Pro Val Asn Pro Tyr Pro 
        115                 120                 125             


Glu Phe Leu Glu Leu Tyr Arg Lys Thr Leu Pro Arg Ser Thr Val Ser 
    130                 135                 140                 


Ile Leu Asp Asp His Ile Ser His Tyr Pro Gln Leu Glu Asp Pro Met 
145                 150                 155                 160 


Gly Phe Leu Asn Ala Tyr Met Gly Phe Ile Asn Ser Phe 
                165                 170             


<210>  8551
<211>  118
<212>  PRT
<213>  Homo Sapiens

<400>  8551

Met Arg Glu Trp Trp Val Gln Val Gly Leu Leu Ala Val Pro Leu Leu 
1               5                   10                  15      


Ala Ala Tyr Leu His Ile Pro Pro Pro Gln Leu Ser Pro Ala Leu His 
            20                  25                  30          


Ser Trp Lys Ser Ser Gly Lys Phe Phe Thr Tyr Lys Gly Leu Arg Ile 
        35                  40                  45              


Phe Tyr Gln Asp Ser Val Gly Val Val Gly Ser Pro Glu Ile Val Val 
    50                  55                  60                  


Leu Leu His Gly Phe Pro Thr Ser Ser Tyr Asp Trp Tyr Lys Ile Trp 
65                  70                  75                  80  


Glu Gly Leu Thr Leu Arg Phe His Arg Val Ile Ala Leu Asp Phe Leu 
                85                  90                  95      


Gly Phe Gly Phe Ser Asp Lys Pro Arg Pro His His Tyr Ser Ile Phe 
            100                 105                 110         


Glu Gln Ala Ser Ile Val 
        115             


<210>  8552
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  8552

Met Arg Glu Trp Trp Val Gln Val Gly Leu Leu Ala Val Pro Leu Leu 
1               5                   10                  15      


Ala Ala Tyr Leu His Ile Pro Pro Pro Gln Leu Ser Pro Ala Leu His 
            20                  25                  30          


Ser Trp Lys Ser Ser Gly Lys Phe Phe Thr Tyr Lys Gly Leu Arg Ile 
        35                  40                  45              


Phe Tyr Gln Asp Ser Val Gly Val Val Gly Ser Pro Glu Ile Val Val 
    50                  55                  60                  


Leu Leu His Gly Phe Pro Thr Ser Ser Tyr Asp Trp Tyr Lys Ile Trp 
65                  70                  75                  80  


Glu Gly Leu Thr Leu Arg Phe His Arg Val Ile Ala Leu Asp Phe Leu 
                85                  90                  95      


Gly Phe Gly Phe Ser Asp Lys Pro Arg Pro His His Tyr Ser Ile Phe 
            100                 105                 110         


Glu Gln Ala Ser Ile Val Glu Ala Leu Leu Arg His Leu Gly Leu Gln 
        115                 120                 125             


Asn Arg Arg Ile Asn Leu Leu Ser His Asp Tyr Gly Asp Ile Val Ala 
    130                 135                 140                 


Gln Glu Leu Leu Tyr Arg Tyr Lys Gln Asn Arg Ser Gly Arg Leu Thr 
145                 150                 155                 160 


<210>  8553
<211>  169
<212>  PRT
<213>  Homo Sapiens

<400>  8553

Met Arg Glu Trp Trp Val Gln Val Gly Leu Leu Ala Val Pro Leu Leu 
1               5                   10                  15      


Ala Ala Tyr Leu His Ile Pro Pro Pro Gln Leu Ser Pro Ala Leu His 
            20                  25                  30          


Ser Trp Lys Ser Ser Gly Lys Phe Phe Thr Tyr Lys Gly Leu Arg Ile 
        35                  40                  45              


Phe Tyr Gln Asp Ser Val Gly Val Val Gly Ser Pro Glu Ile Val Val 
    50                  55                  60                  


Leu Leu His Gly Phe Pro Thr Ser Ser Tyr Asp Trp Tyr Lys Ile Trp 
65                  70                  75                  80  


Glu Gly Leu Thr Leu Arg Phe His Arg Val Ile Ala Leu Asp Phe Leu 
                85                  90                  95      


Gly Phe Gly Phe Ser Asp Lys Pro Arg Pro His His Tyr Ser Ile Phe 
            100                 105                 110         


Glu Gln Ala Ser Ile Val Glu Ala Leu Leu Arg His Leu Gly Leu Gln 
        115                 120                 125             


Asn Arg Arg Ile Asn Leu Leu Ser His Asp Tyr Gly Asp Ile Val Ala 
    130                 135                 140                 


Gln Glu Leu Leu Tyr Arg Tyr Lys Gln Asn Arg Ser Gly Arg Leu Thr 
145                 150                 155                 160 


Ile Lys Ser Leu Cys Leu Ser Asn Gly 
                165                 


<210>  8554
<211>  188
<212>  PRT
<213>  Homo Sapiens

<400>  8554

Met Arg Glu Trp Trp Val Gln Val Gly Leu Leu Ala Val Pro Leu Leu 
1               5                   10                  15      


Ala Ala Tyr Leu His Ile Pro Pro Pro Gln Leu Ser Pro Ala Leu His 
            20                  25                  30          


Ser Trp Lys Ser Ser Gly Lys Phe Phe Thr Tyr Lys Gly Leu Arg Ile 
        35                  40                  45              


Phe Tyr Gln Asp Ser Val Gly Val Val Gly Ser Pro Glu Ile Val Val 
    50                  55                  60                  


Leu Leu His Gly Phe Pro Thr Ser Ser Tyr Asp Trp Tyr Lys Ile Trp 
65                  70                  75                  80  


Glu Gly Leu Thr Leu Arg Phe His Arg Val Ile Ala Leu Asp Phe Leu 
                85                  90                  95      


Gly Phe Gly Phe Ser Asp Lys Pro Arg Pro His His Tyr Ser Ile Phe 
            100                 105                 110         


Glu Gln Ala Ser Ile Val Glu Ala Leu Leu Arg His Leu Gly Leu Gln 
        115                 120                 125             


Asn Arg Arg Ile Asn Leu Leu Ser His Asp Tyr Gly Asp Ile Val Ala 
    130                 135                 140                 


Gln Glu Leu Leu Tyr Arg Tyr Lys Gln Asn Arg Ser Gly Arg Leu Thr 
145                 150                 155                 160 


Ile Lys Ser Leu Cys Leu Ser Asn Gly Gly Ile Phe Pro Glu Thr His 
                165                 170                 175     


Arg Pro Leu Leu Leu Gln Lys Leu Leu Lys Asp Gly 
            180                 185             


<210>  8555
<211>  292
<212>  PRT
<213>  Homo Sapiens

<400>  8555

Met Arg Glu Trp Trp Val Gln Val Gly Leu Leu Ala Val Pro Leu Leu 
1               5                   10                  15      


Ala Ala Tyr Leu His Ile Pro Pro Pro Gln Leu Ser Pro Ala Leu His 
            20                  25                  30          


Ser Trp Lys Ser Ser Gly Lys Phe Phe Thr Tyr Lys Gly Leu Arg Ile 
        35                  40                  45              


Phe Tyr Gln Asp Ser Val Gly Val Val Gly Ser Pro Glu Ile Val Val 
    50                  55                  60                  


Leu Leu His Gly Phe Pro Thr Ser Ser Tyr Asp Trp Tyr Lys Ile Trp 
65                  70                  75                  80  


Glu Gly Leu Thr Leu Arg Phe His Arg Val Ile Ala Leu Asp Phe Leu 
                85                  90                  95      


Gly Phe Gly Phe Ser Asp Lys Pro Arg Pro His His Tyr Ser Ile Phe 
            100                 105                 110         


Glu Gln Ala Ser Ile Val Glu Ala Leu Leu Arg His Leu Gly Leu Gln 
        115                 120                 125             


Asn Arg Arg Ile Asn Leu Leu Ser His Asp Tyr Gly Asp Ile Val Ala 
    130                 135                 140                 


Gln Glu Leu Leu Tyr Arg Tyr Lys Gln Asn Arg Ser Gly Arg Leu Thr 
145                 150                 155                 160 


Ile Lys Ser Leu Cys Leu Ser Asn Gly Gly Ile Phe Pro Glu Thr His 
                165                 170                 175     


Arg Pro Leu Leu Leu Gln Lys Leu Leu Lys Asp Gly Gly Val Leu Ser 
            180                 185                 190         


Pro Ile Leu Thr Arg Leu Met Asn Phe Phe Val Phe Ser Arg Gly Leu 
        195                 200                 205             


Leu Gln Tyr Ile Asn Gln Arg Lys Lys Phe Arg Arg Arg Trp Val Gly 
    210                 215                 220                 


Ala Leu Ala Ser Val Thr Ile Pro Ile His Phe Ile Tyr Gly Pro Leu 
225                 230                 235                 240 


Asp Pro Val Asn Pro Tyr Pro Glu Phe Leu Glu Leu Tyr Arg Lys Thr 
                245                 250                 255     


Leu Pro Arg Ser Thr Val Ser Ile Leu Asp Asp His Ile Ser His Tyr 
            260                 265                 270         


Pro Gln Leu Glu Asp Pro Met Gly Phe Leu Asn Ala Tyr Met Gly Phe 
        275                 280                 285             


Ile Asn Ser Phe 
    290         


<210>  8556
<211>  292
<212>  PRT
<213>  Homo Sapiens

<400>  8556

Met Arg Glu Trp Trp Val Gln Val Gly Leu Leu Ala Val Pro Leu Leu 
1               5                   10                  15      


Ala Ala Tyr Leu His Ile Pro Pro Pro Gln Leu Ser Pro Ala Leu His 
            20                  25                  30          


Ser Trp Lys Ser Ser Gly Lys Phe Phe Thr Tyr Lys Gly Leu Arg Ile 
        35                  40                  45              


Phe Tyr Gln Asp Ser Val Gly Val Val Gly Ser Pro Glu Ile Val Val 
    50                  55                  60                  


Leu Leu His Gly Phe Pro Thr Ser Ser Tyr Asp Trp Tyr Lys Ile Trp 
65                  70                  75                  80  


Glu Gly Leu Thr Leu Arg Phe His Arg Val Ile Ala Leu Asp Phe Leu 
                85                  90                  95      


Gly Phe Gly Phe Ser Asp Lys Pro Arg Pro His His Tyr Ser Ile Phe 
            100                 105                 110         


Glu Gln Ala Ser Ile Val Glu Ala Leu Leu Arg His Leu Gly Leu Gln 
        115                 120                 125             


Asn Arg Arg Ile Asn Leu Leu Ser His Asp Tyr Gly Asp Ile Val Ala 
    130                 135                 140                 


Gln Glu Leu Leu Tyr Arg Tyr Lys Gln Asn Arg Ser Gly Arg Leu Thr 
145                 150                 155                 160 


Ile Lys Ser Leu Cys Leu Ser Asn Gly Gly Ile Phe Pro Glu Thr His 
                165                 170                 175     


Arg Pro Leu Leu Leu Gln Lys Leu Leu Lys Asp Gly Gly Val Leu Ser 
            180                 185                 190         


Pro Ile Leu Thr Arg Leu Met Asn Phe Phe Val Phe Ser Arg Gly Leu 
        195                 200                 205             


Leu Gln Tyr Ile Asn Gln Arg Lys Lys Phe Arg Arg Arg Trp Val Gly 
    210                 215                 220                 


Ala Leu Ala Ser Val Thr Ile Pro Ile His Phe Ile Tyr Gly Pro Leu 
225                 230                 235                 240 


Asp Pro Val Asn Pro Tyr Pro Glu Phe Leu Glu Leu Tyr Arg Lys Thr 
                245                 250                 255     


Leu Pro Arg Ser Thr Val Ser Ile Leu Asp Asp His Ile Ser His Tyr 
            260                 265                 270         


Pro Gln Leu Glu Asp Pro Met Gly Phe Leu Asn Ala Tyr Met Gly Phe 
        275                 280                 285             


Ile Asn Ser Phe 
    290         


<210>  8557
<211>  292
<212>  PRT
<213>  Homo Sapiens

<400>  8557

Met Arg Glu Trp Trp Val Gln Val Gly Leu Leu Ala Val Pro Leu Leu 
1               5                   10                  15      


Ala Ala Tyr Leu His Ile Pro Pro Pro Gln Leu Ser Pro Ala Leu His 
            20                  25                  30          


Ser Trp Lys Ser Ser Gly Lys Phe Phe Thr Tyr Lys Gly Leu Arg Ile 
        35                  40                  45              


Phe Tyr Gln Asp Ser Val Gly Val Val Gly Ser Pro Glu Ile Val Val 
    50                  55                  60                  


Leu Leu His Gly Phe Pro Thr Ser Ser Tyr Asp Trp Tyr Lys Ile Trp 
65                  70                  75                  80  


Glu Gly Leu Thr Leu Arg Phe His Arg Val Ile Ala Leu Asp Phe Leu 
                85                  90                  95      


Gly Phe Gly Phe Ser Asp Lys Pro Arg Pro His His Tyr Ser Ile Phe 
            100                 105                 110         


Glu Gln Ala Ser Ile Val Glu Ala Leu Leu Arg His Leu Gly Leu Gln 
        115                 120                 125             


Asn Arg Arg Ile Asn Leu Leu Ser His Asp Tyr Gly Asp Ile Val Ala 
    130                 135                 140                 


Gln Glu Leu Leu Tyr Arg Tyr Lys Gln Asn Arg Ser Gly Arg Leu Thr 
145                 150                 155                 160 


Ile Lys Ser Leu Cys Leu Ser Asn Gly Gly Ile Phe Pro Glu Thr His 
                165                 170                 175     


Arg Pro Leu Leu Leu Gln Lys Leu Leu Lys Asp Gly Gly Val Leu Ser 
            180                 185                 190         


Pro Ile Leu Thr Arg Leu Met Asn Phe Phe Val Phe Ser Arg Gly Leu 
        195                 200                 205             


Leu Gln Tyr Ile Asn Gln Arg Lys Lys Phe Arg Arg Arg Trp Val Gly 
    210                 215                 220                 


Ala Leu Ala Ser Val Thr Ile Pro Ile His Phe Ile Tyr Gly Pro Leu 
225                 230                 235                 240 


Asp Pro Val Asn Pro Tyr Pro Glu Phe Leu Glu Leu Tyr Arg Lys Thr 
                245                 250                 255     


Leu Pro Arg Ser Thr Val Ser Ile Leu Asp Asp His Ile Ser His Tyr 
            260                 265                 270         


Pro Gln Leu Glu Asp Pro Met Gly Phe Leu Asn Ala Tyr Met Gly Phe 
        275                 280                 285             


Ile Asn Ser Phe 
    290         


<210>  8558
<211>  213
<212>  PRT
<213>  Homo Sapiens

<400>  8558

Met Arg Glu Trp Trp Val Gln Val Gly Leu Leu Ala Val Pro Leu Leu 
1               5                   10                  15      


Ala Ala Tyr Leu His Ile Pro Pro Pro Gln Leu Ser Pro Ala Leu His 
            20                  25                  30          


Ser Trp Lys Ser Ser Gly Lys Phe Phe Thr Tyr Lys Gly Leu Arg Ile 
        35                  40                  45              


Phe Tyr Gln Asp Ser Val Gly Val Val Gly Ser Pro Glu Ile Val Val 
    50                  55                  60                  


Leu Leu His Gly Phe Pro Thr Ser Ser Tyr Asp Trp Tyr Lys Ile Trp 
65                  70                  75                  80  


Glu Gly Leu Thr Leu Arg Phe His Arg Val Ile Ala Leu Asp Phe Leu 
                85                  90                  95      


Gly Phe Gly Phe Ser Asp Lys Pro Arg Pro His His Tyr Ser Ile Phe 
            100                 105                 110         


Glu Gln Ala Ser Ile Val Glu Ala Leu Leu Arg His Leu Gly Leu Gln 
        115                 120                 125             


Asn Arg Arg Ile Asn Leu Leu Ser His Asp Tyr Gly Asp Ile Val Ala 
    130                 135                 140                 


Gln Glu Leu Leu Tyr Arg Tyr Lys Gln Asn Arg Ser Gly Arg Leu Thr 
145                 150                 155                 160 


Ile Lys Ser Leu Cys Leu Ser Asn Gly Gly Ile Phe Pro Glu Thr His 
                165                 170                 175     


Arg Pro Leu Leu Leu Gln Lys Leu Leu Lys Asp Gly Gly Val Leu Ser 
            180                 185                 190         


Pro Ile Leu Thr Arg Leu Met Asn Phe Phe Val Phe Ser Arg Gly Leu 
        195                 200                 205             


Thr Pro Val Phe Gly 
    210             


<210>  8559
<211>  326
<212>  PRT
<213>  Homo Sapiens

<400>  8559

Met Arg Glu Trp Trp Val Gln Val Gly Leu Leu Ala Val Pro Leu Leu 
1               5                   10                  15      


Ala Ala Tyr Leu His Ile Pro Pro Pro Gln Leu Ser Pro Ala Leu His 
            20                  25                  30          


Ser Trp Lys Ser Ser Gly Lys Phe Phe Thr Tyr Lys Gly Leu Arg Ile 
        35                  40                  45              


Phe Tyr Gln Asp Ser Val Gly Val Val Gly Ser Pro Glu Ile Val Val 
    50                  55                  60                  


Leu Leu His Gly Phe Pro Thr Ser Ser Tyr Asp Trp Tyr Lys Ile Trp 
65                  70                  75                  80  


Glu Gly Leu Thr Leu Arg Phe His Arg Val Ile Ala Leu Asp Phe Leu 
                85                  90                  95      


Gly Phe Gly Phe Ser Asp Lys Pro Arg Pro His His Tyr Ser Ile Phe 
            100                 105                 110         


Glu Gln Ala Ser Ile Val Glu Ala Leu Leu Arg His Leu Gly Leu Gln 
        115                 120                 125             


Asn Arg Arg Ile Asn Leu Leu Ser His Asp Tyr Gly Asp Ile Val Ala 
    130                 135                 140                 


Gln Glu Leu Leu Tyr Arg Tyr Lys Gln Asn Arg Ser Gly Arg Leu Thr 
145                 150                 155                 160 


Ile Lys Ser Leu Cys Leu Ser Asn Gly Gly Ile Phe Pro Glu Thr His 
                165                 170                 175     


Arg Pro Leu Leu Leu Gln Lys Leu Leu Lys Asp Gly Gly Val Leu Ser 
            180                 185                 190         


Pro Ile Leu Thr Arg Leu Met Asn Phe Phe Val Phe Ser Arg Gly Leu 
        195                 200                 205             


Thr Pro Val Phe Gly Pro Tyr Thr Arg Pro Ser Glu Ser Glu Leu Trp 
    210                 215                 220                 


Asp Met Trp Ala Gly Ile Arg Asn Asn Asp Gly Asn Leu Val Ile Asp 
225                 230                 235                 240 


Ser Leu Leu Gln Tyr Ile Asn Gln Arg Lys Lys Phe Arg Arg Arg Trp 
                245                 250                 255     


Val Gly Ala Leu Ala Ser Val Thr Ile Pro Ile His Phe Ile Tyr Gly 
            260                 265                 270         


Pro Leu Asp Pro Val Asn Pro Tyr Pro Glu Phe Leu Glu Leu Tyr Arg 
        275                 280                 285             


Lys Thr Leu Pro Arg Ser Thr Val Ser Ile Leu Asp Asp His Ile Ser 
    290                 295                 300                 


His Tyr Pro Gln Leu Glu Asp Pro Met Gly Phe Leu Asn Ala Tyr Met 
305                 310                 315                 320 


Gly Phe Ile Asn Ser Phe 
                325     


<210>  8560
<211>  326
<212>  PRT
<213>  Homo Sapiens

<400>  8560

Met Arg Glu Trp Trp Val Gln Val Gly Leu Leu Ala Val Pro Leu Leu 
1               5                   10                  15      


Ala Ala Tyr Leu His Ile Pro Pro Pro Gln Leu Ser Pro Ala Leu His 
            20                  25                  30          


Ser Trp Lys Ser Ser Gly Lys Phe Phe Thr Tyr Lys Gly Leu Arg Ile 
        35                  40                  45              


Phe Tyr Gln Asp Ser Val Gly Val Val Gly Ser Pro Glu Ile Val Val 
    50                  55                  60                  


Leu Leu His Gly Phe Pro Thr Ser Ser Tyr Asp Trp Tyr Lys Ile Trp 
65                  70                  75                  80  


Glu Gly Leu Thr Leu Arg Phe His Arg Val Ile Ala Leu Asp Phe Leu 
                85                  90                  95      


Gly Phe Gly Phe Ser Asp Lys Pro Arg Pro His His Tyr Ser Ile Phe 
            100                 105                 110         


Glu Gln Ala Ser Ile Val Glu Ala Leu Leu Arg His Leu Gly Leu Gln 
        115                 120                 125             


Asn Arg Arg Ile Asn Leu Leu Ser His Asp Tyr Gly Asp Ile Val Ala 
    130                 135                 140                 


Gln Glu Leu Leu Tyr Arg Tyr Lys Gln Asn Arg Ser Gly Arg Leu Thr 
145                 150                 155                 160 


Ile Lys Ser Leu Cys Leu Ser Asn Gly Gly Ile Phe Pro Glu Thr His 
                165                 170                 175     


Arg Pro Leu Leu Leu Gln Lys Leu Leu Lys Asp Gly Gly Val Leu Ser 
            180                 185                 190         


Pro Ile Leu Thr Arg Leu Met Asn Phe Phe Val Phe Ser Arg Gly Leu 
        195                 200                 205             


Thr Pro Val Phe Gly Pro Tyr Thr Arg Pro Ser Glu Ser Glu Leu Trp 
    210                 215                 220                 


Asp Met Trp Ala Gly Ile Arg Asn Asn Asp Gly Asn Leu Val Ile Asp 
225                 230                 235                 240 


Ser Leu Leu Gln Tyr Ile Asn Gln Arg Lys Lys Phe Arg Arg Arg Trp 
                245                 250                 255     


Val Gly Ala Leu Ala Ser Val Thr Ile Pro Ile His Phe Ile Tyr Gly 
            260                 265                 270         


Pro Leu Asp Pro Val Asn Pro Tyr Pro Glu Phe Leu Glu Leu Tyr Arg 
        275                 280                 285             


Lys Thr Leu Pro Arg Ser Thr Val Ser Ile Leu Asp Asp His Ile Ser 
    290                 295                 300                 


His Tyr Pro Gln Leu Glu Asp Pro Met Gly Phe Leu Asn Ala Tyr Met 
305                 310                 315                 320 


Gly Phe Ile Asn Ser Phe 
                325     


<210>  8561
<211>  326
<212>  PRT
<213>  Homo Sapiens

<400>  8561

Met Arg Glu Trp Trp Val Gln Val Gly Leu Leu Ala Val Pro Leu Leu 
1               5                   10                  15      


Ala Ala Tyr Leu His Ile Pro Pro Pro Gln Leu Ser Pro Ala Leu His 
            20                  25                  30          


Ser Trp Lys Ser Ser Gly Lys Phe Phe Thr Tyr Lys Gly Leu Arg Ile 
        35                  40                  45              


Phe Tyr Gln Asp Ser Val Gly Val Val Gly Ser Pro Glu Ile Val Val 
    50                  55                  60                  


Leu Leu His Gly Phe Pro Thr Ser Ser Tyr Asp Trp Tyr Lys Ile Trp 
65                  70                  75                  80  


Glu Gly Leu Thr Leu Arg Phe His Arg Val Ile Ala Leu Asp Phe Leu 
                85                  90                  95      


Gly Phe Gly Phe Ser Asp Lys Pro Arg Pro His His Tyr Ser Ile Phe 
            100                 105                 110         


Glu Gln Ala Ser Ile Val Glu Ala Leu Leu Arg His Leu Gly Leu Gln 
        115                 120                 125             


Asn Arg Arg Ile Asn Leu Leu Ser His Asp Tyr Gly Asp Ile Val Ala 
    130                 135                 140                 


Gln Glu Leu Leu Tyr Arg Tyr Lys Gln Asn Arg Ser Gly Arg Leu Thr 
145                 150                 155                 160 


Ile Lys Ser Leu Cys Leu Ser Asn Gly Gly Ile Phe Pro Glu Thr His 
                165                 170                 175     


Arg Pro Leu Leu Leu Gln Lys Leu Leu Lys Asp Gly Gly Val Leu Ser 
            180                 185                 190         


Pro Ile Leu Thr Arg Leu Met Asn Phe Phe Val Phe Ser Arg Gly Leu 
        195                 200                 205             


Thr Pro Val Phe Gly Pro Tyr Thr Arg Pro Ser Glu Ser Glu Leu Trp 
    210                 215                 220                 


Asp Met Trp Ala Gly Ile Arg Asn Asn Asp Gly Asn Leu Val Ile Asp 
225                 230                 235                 240 


Ser Leu Leu Gln Tyr Ile Asn Gln Arg Lys Lys Phe Arg Arg Arg Trp 
                245                 250                 255     


Val Gly Ala Leu Ala Ser Val Thr Ile Pro Ile His Phe Ile Tyr Gly 
            260                 265                 270         


Pro Leu Asp Pro Val Asn Pro Tyr Pro Glu Phe Leu Glu Leu Tyr Arg 
        275                 280                 285             


Lys Thr Leu Pro Arg Ser Thr Val Ser Ile Leu Asp Asp His Ile Ser 
    290                 295                 300                 


His Tyr Pro Gln Leu Glu Asp Pro Met Gly Phe Leu Asn Ala Tyr Met 
305                 310                 315                 320 


Gly Phe Ile Asn Ser Phe 
                325     


<210>  8562
<211>  325
<212>  PRT
<213>  Homo Sapiens

<400>  8562

Met Val Arg Arg Asp Arg Leu Arg Arg Met Arg Glu Trp Trp Val Gln 
1               5                   10                  15      


Val Gly Leu Leu Ala Val Pro Leu Leu Ala Ala Tyr Leu His Ile Pro 
            20                  25                  30          


Pro Pro Gln Leu Ser Pro Ala Leu His Ser Trp Lys Ser Ser Gly Lys 
        35                  40                  45              


Phe Phe Thr Tyr Lys Gly Leu Arg Ile Phe Tyr Gln Asp Ser Val Gly 
    50                  55                  60                  


Val Val Gly Ser Pro Glu Ile Val Val Leu Leu His Gly Phe Pro Thr 
65                  70                  75                  80  


Ser Ser Tyr Asp Trp Tyr Lys Ile Trp Glu Gly Leu Thr Leu Arg Phe 
                85                  90                  95      


His Arg Val Ile Ala Leu Asp Phe Leu Gly Phe Gly Phe Ser Asp Lys 
            100                 105                 110         


Pro Ala Ser Ile Val Glu Ala Leu Leu Arg His Leu Gly Leu Gln Asn 
        115                 120                 125             


Arg Arg Ile Asn Leu Leu Ser His Asp Tyr Gly Asp Ile Val Ala Gln 
    130                 135                 140                 


Glu Leu Leu Tyr Arg Tyr Lys Gln Asn Arg Ser Gly Arg Leu Thr Ile 
145                 150                 155                 160 


Lys Ser Leu Cys Leu Ser Asn Gly Gly Ile Phe Pro Glu Thr His Arg 
                165                 170                 175     


Pro Leu Leu Leu Gln Lys Leu Leu Lys Asp Gly Gly Val Leu Ser Pro 
            180                 185                 190         


Ile Leu Thr Arg Leu Met Asn Phe Phe Val Phe Ser Arg Gly Leu Thr 
        195                 200                 205             


Pro Val Phe Gly Pro Tyr Thr Arg Pro Ser Glu Ser Glu Leu Trp Asp 
    210                 215                 220                 


Met Trp Ala Gly Ile Arg Asn Asn Asp Gly Asn Leu Val Ile Asp Ser 
225                 230                 235                 240 


Leu Leu Gln Tyr Ile Asn Gln Arg Lys Lys Phe Arg Arg Arg Trp Val 
                245                 250                 255     


Gly Ala Leu Ala Ser Val Thr Ile Pro Ile His Phe Ile Tyr Gly Pro 
            260                 265                 270         


Leu Asp Pro Val Asn Pro Tyr Pro Glu Phe Leu Glu Leu Tyr Arg Lys 
        275                 280                 285             


Thr Leu Pro Arg Ser Thr Val Ser Ile Leu Asp Asp His Ile Ser His 
    290                 295                 300                 


Tyr Pro Gln Leu Glu Asp Pro Met Gly Phe Leu Asn Ala Tyr Met Gly 
305                 310                 315                 320 


Phe Ile Asn Ser Phe 
                325 


<210>  8563
<211>  335
<212>  PRT
<213>  Homo Sapiens

<400>  8563

Met Val Arg Arg Asp Arg Leu Arg Arg Met Arg Glu Trp Trp Val Gln 
1               5                   10                  15      


Val Gly Leu Leu Ala Val Pro Leu Leu Ala Ala Tyr Leu His Ile Pro 
            20                  25                  30          


Pro Pro Gln Leu Ser Pro Ala Leu His Ser Trp Lys Ser Ser Gly Lys 
        35                  40                  45              


Phe Phe Thr Tyr Lys Gly Leu Arg Ile Phe Tyr Gln Asp Ser Val Gly 
    50                  55                  60                  


Val Val Gly Ser Pro Glu Ile Val Val Leu Leu His Gly Phe Pro Thr 
65                  70                  75                  80  


Ser Ser Tyr Asp Trp Tyr Lys Ile Trp Glu Gly Leu Thr Leu Arg Phe 
                85                  90                  95      


His Arg Val Ile Ala Leu Asp Phe Leu Gly Phe Gly Phe Ser Asp Lys 
            100                 105                 110         


Pro Arg Pro His His Tyr Ser Ile Phe Glu Gln Ala Ser Ile Val Glu 
        115                 120                 125             


Ala Leu Leu Arg His Leu Gly Leu Gln Asn Arg Arg Ile Asn Leu Leu 
    130                 135                 140                 


Ser His Asp Tyr Gly Asp Ile Val Ala Gln Glu Leu Leu Tyr Arg Tyr 
145                 150                 155                 160 


Lys Gln Asn Arg Ser Gly Arg Leu Thr Ile Lys Ser Leu Cys Leu Ser 
                165                 170                 175     


Asn Gly Gly Ile Phe Pro Glu Thr His Arg Pro Leu Leu Leu Gln Lys 
            180                 185                 190         


Leu Leu Lys Asp Gly Gly Val Leu Ser Pro Ile Leu Thr Arg Leu Met 
        195                 200                 205             


Asn Phe Phe Val Phe Ser Arg Gly Leu Thr Pro Val Phe Gly Pro Tyr 
    210                 215                 220                 


Thr Arg Pro Ser Glu Ser Glu Leu Trp Asp Met Trp Ala Gly Ile Arg 
225                 230                 235                 240 


Asn Asn Asp Gly Asn Leu Val Ile Asp Ser Leu Leu Gln Tyr Ile Asn 
                245                 250                 255     


Gln Arg Lys Lys Phe Arg Arg Arg Trp Val Gly Ala Leu Ala Ser Val 
            260                 265                 270         


Thr Ile Pro Ile His Phe Ile Tyr Gly Pro Leu Asp Pro Val Asn Pro 
        275                 280                 285             


Tyr Pro Glu Phe Leu Glu Leu Tyr Arg Lys Thr Leu Pro Arg Ser Thr 
    290                 295                 300                 


Val Ser Ile Leu Asp Asp His Ile Ser His Tyr Pro Gln Leu Glu Asp 
305                 310                 315                 320 


Pro Met Gly Phe Leu Asn Ala Tyr Met Gly Phe Ile Asn Ser Phe 
                325                 330                 335 


<210>  8564
<211>  158
<212>  PRT
<213>  Homo Sapiens

<400>  8564

Ala Val Lys Gly Glu Val Leu Lys Val Gly Asn Lys Ser Cys Glu Asn 
1               5                   10                  15      


Ile His Leu His Ser Glu Ala Val Leu Cys Thr Val Pro Asn Asp Leu 
            20                  25                  30          


Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu Trp Lys Gln Ala Ile Ser 
        35                  40                  45              


Ser Thr Val Leu Gly Lys Val Ile Val Gln Pro Asp Gln Asn Phe Thr 
    50                  55                  60                  


Gly Leu Ile Ala Gly Val Val Ser Ile Ser Thr Ala Leu Leu Leu Leu 
65                  70                  75                  80  


Leu Gly Phe Phe Leu Trp Leu Lys Lys Arg Lys Gln Ile Lys Asp Gln 
                85                  90                  95      


Phe Pro Asn Ser Ser Gln Asn Gly Ser Cys Arg Gln Val Gln Tyr Pro 
            100                 105                 110         


Leu Thr Asp Met Ser Pro Ile Leu Thr Ser Gly Asp Ser Asp Ile Ser 
        115                 120                 125             


Ser Pro Leu Leu Gln Asn Thr Val His Ile Asp Leu Ser Ala Leu Asn 
    130                 135                 140                 


Pro Glu Leu Val Gln Ala Val Gln His Val Val Ile Gly Pro 
145                 150                 155             


<210>  8565
<211>  214
<212>  PRT
<213>  Homo Sapiens

<400>  8565

Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe 
1               5                   10                  15      


Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser 
            20                  25                  30          


Phe Ile Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn Leu Asn 
        35                  40                  45              


Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala Gly Arg 
    50                  55                  60                  


Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile Ile Cys 
65                  70                  75                  80  


Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn Leu Gln Leu Pro Leu Lys 
                85                  90                  95      


Thr Lys Ala Phe Phe Met Leu Asp Gly Ile Leu Ser Lys Tyr Phe Asp 
            100                 105                 110         


Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys Pro Val 
        115                 120                 125             


Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly Asn Asp 
    130                 135                 140                 


Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly Asn Lys 
145                 150                 155                 160 


Ser Cys Glu Asn Ile His Leu His Ser Glu Ala Val Leu Cys Thr Val 
                165                 170                 175     


Pro Asn Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu Val Gly 
            180                 185                 190         


Phe Leu His Ser Ser His Asp Val Asn Lys Glu Ala Ser Val Ile Met 
        195                 200                 205             


Leu Phe Ser Gly Leu Lys 
    210                 


<210>  8566
<211>  1408
<212>  PRT
<213>  Homo Sapiens

<400>  8566

Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe 
1               5                   10                  15      


Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys 
            20                  25                  30          


Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala 
        35                  40                  45              


Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu 
    50                  55                  60                  


Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys 
65                  70                  75                  80  


Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe 
                85                  90                  95      


Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp 
            100                 105                 110         


Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp 
        115                 120                 125             


Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His 
    130                 135                 140                 


Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys 
145                 150                 155                 160 


Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val 
                165                 170                 175     


Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe 
            180                 185                 190         


Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp 
        195                 200                 205             


His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp 
    210                 215                 220                 


Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu 
225                 230                 235                 240 


Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn 
                245                 250                 255     


Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln 
            260                 265                 270         


Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu 
        275                 280                 285             


His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg 
    290                 295                 300                 


Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala 
305                 310                 315                 320 


Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser 
                325                 330                 335     


Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp 
            340                 345                 350         


Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys 
        355                 360                 365             


Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg 
    370                 375                 380                 


Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg 
385                 390                 395                 400 


Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr 
                405                 410                 415     


Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly 
            420                 425                 430         


Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly 
        435                 440                 445             


Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln 
    450                 455                 460                 


Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu 
465                 470                 475                 480 


Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu 
                485                 490                 495     


Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys 
            500                 505                 510         


Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln 
        515                 520                 525             


Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys 
    530                 535                 540                 


Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile 
545                 550                 555                 560 


Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu 
                565                 570                 575     


Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg 
            580                 585                 590         


Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu 
        595                 600                 605             


Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys 
    610                 615                 620                 


Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile 
625                 630                 635                 640 


Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp 
                645                 650                 655     


Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly 
            660                 665                 670         


Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg 
        675                 680                 685             


His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn 
    690                 695                 700                 


Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe 
705                 710                 715                 720 


Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe 
                725                 730                 735     


Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser 
            740                 745                 750         


Phe Ile Ser Thr Trp Trp Lys Glu Pro Leu Asn Ile Val Ser Phe Leu 
        755                 760                 765             


Phe Cys Phe Ala Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn 
    770                 775                 780                 


Leu Asn Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala 
785                 790                 795                 800 


Gly Arg Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile 
                805                 810                 815     


Ile Cys Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn Leu Gln Leu Pro 
            820                 825                 830         


Leu Lys Thr Lys Ala Phe Phe Met Leu Asp Gly Ile Leu Ser Lys Tyr 
        835                 840                 845             


Phe Asp Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys 
    850                 855                 860                 


Pro Val Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly 
865                 870                 875                 880 


Asn Asp Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly 
                885                 890                 895     


Asn Lys Ser Cys Glu Asn Ile His Leu His Ser Glu Ala Val Leu Cys 
            900                 905                 910         


Thr Val Pro Asn Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu 
        915                 920                 925             


Trp Lys Gln Ala Ile Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln 
    930                 935                 940                 


Pro Asp Gln Asn Phe Thr Gly Leu Ile Ala Gly Val Val Ser Ile Ser 
945                 950                 955                 960 


Thr Ala Leu Leu Leu Leu Leu Gly Phe Phe Leu Trp Leu Lys Lys Arg 
                965                 970                 975     


Lys Gln Ile Lys Asp Leu Gly Ser Glu Leu Val Arg Tyr Asp Ala Arg 
            980                 985                 990         


Val His Thr Pro His Leu Asp Arg  Leu Val Ser Ala Arg  Ser Val Ser 
        995                 1000                 1005             


Pro Thr  Thr Glu Met Val Ser  Asn Glu Ser Val Asp  Tyr Arg Ala 
    1010                 1015                 1020             


Thr Phe  Pro Glu Asp Gln Phe  Pro Asn Ser Ser Gln  Asn Gly Ser 
    1025                 1030                 1035             


Cys Arg  Gln Val Gln Tyr Pro  Leu Thr Asp Met Ser  Pro Ile Leu 
    1040                 1045                 1050             


Thr Ser  Gly Asp Ser Asp Ile  Ser Ser Pro Leu Leu  Gln Asn Thr 
    1055                 1060                 1065             


Val His  Ile Asp Leu Ser Ala  Leu Asn Pro Glu Leu  Val Gln Ala 
    1070                 1075                 1080             


Val Gln  His Val Val Ile Gly  Pro Ser Ser Leu Ile  Val His Phe 
    1085                 1090                 1095             


Asn Glu  Val Ile Gly Arg Gly  His Phe Gly Cys Val  Tyr His Gly 
    1100                 1105                 1110             


Thr Leu  Leu Asp Asn Asp Gly  Lys Lys Ile His Cys  Ala Val Lys 
    1115                 1120                 1125             


Ser Leu  Asn Arg Ile Thr Asp  Ile Gly Glu Val Ser  Gln Phe Leu 
    1130                 1135                 1140             


Thr Glu  Gly Ile Ile Met Lys  Asp Phe Ser His Pro  Asn Val Leu 
    1145                 1150                 1155             


Ser Leu  Leu Gly Ile Cys Leu  Arg Ser Glu Gly Ser  Pro Leu Val 
    1160                 1165                 1170             


Val Leu  Pro Tyr Met Lys His  Gly Asp Leu Arg Asn  Phe Ile Arg 
    1175                 1180                 1185             


Asn Glu  Thr His Asn Pro Thr  Val Lys Asp Leu Ile  Gly Phe Gly 
    1190                 1195                 1200             


Leu Gln  Val Ala Lys Gly Met  Lys Tyr Leu Ala Ser  Lys Lys Phe 
    1205                 1210                 1215             


Val His  Arg Asp Leu Ala Ala  Arg Asn Cys Met Leu  Asp Glu Lys 
    1220                 1225                 1230             


Phe Thr  Val Lys Val Ala Asp  Phe Gly Leu Ala Arg  Asp Met Tyr 
    1235                 1240                 1245             


Asp Lys  Glu Tyr Tyr Ser Val  His Asn Lys Thr Gly  Ala Lys Leu 
    1250                 1255                 1260             


Pro Val  Lys Trp Met Ala Leu  Glu Ser Leu Gln Thr  Gln Lys Phe 
    1265                 1270                 1275             


Thr Thr  Lys Ser Asp Val Trp  Ser Phe Gly Val Leu  Leu Trp Glu 
    1280                 1285                 1290             


Leu Met  Thr Arg Gly Ala Pro  Pro Tyr Pro Asp Val  Asn Thr Phe 
    1295                 1300                 1305             


Asp Ile  Thr Val Tyr Leu Leu  Gln Gly Arg Arg Leu  Leu Gln Pro 
    1310                 1315                 1320             


Glu Tyr  Cys Pro Asp Pro Leu  Tyr Glu Val Met Leu  Lys Cys Trp 
    1325                 1330                 1335             


His Pro  Lys Ala Glu Met Arg  Pro Ser Phe Ser Glu  Leu Val Ser 
    1340                 1345                 1350             


Arg Ile  Ser Ala Ile Phe Ser  Thr Phe Ile Gly Glu  His Tyr Val 
    1355                 1360                 1365             


His Val  Asn Ala Thr Tyr Val  Asn Val Lys Cys Val  Ala Pro Tyr 
    1370                 1375                 1380             


Pro Ser  Leu Leu Ser Ser Glu  Asp Asn Ala Asp Asp  Glu Val Asp 
    1385                 1390                 1395             


Thr Arg  Pro Ala Ser Phe Trp  Glu Thr Ser 
    1400                 1405             


<210>  8567
<211>  1390
<212>  PRT
<213>  Homo Sapiens

<400>  8567

Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe 
1               5                   10                  15      


Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys 
            20                  25                  30          


Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala 
        35                  40                  45              


Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu 
    50                  55                  60                  


Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys 
65                  70                  75                  80  


Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe 
                85                  90                  95      


Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp 
            100                 105                 110         


Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp 
        115                 120                 125             


Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His 
    130                 135                 140                 


Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys 
145                 150                 155                 160 


Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val 
                165                 170                 175     


Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe 
            180                 185                 190         


Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp 
        195                 200                 205             


His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp 
    210                 215                 220                 


Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu 
225                 230                 235                 240 


Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn 
                245                 250                 255     


Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln 
            260                 265                 270         


Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu 
        275                 280                 285             


His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg 
    290                 295                 300                 


Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala 
305                 310                 315                 320 


Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser 
                325                 330                 335     


Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp 
            340                 345                 350         


Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys 
        355                 360                 365             


Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg 
    370                 375                 380                 


Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg 
385                 390                 395                 400 


Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr 
                405                 410                 415     


Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly 
            420                 425                 430         


Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly 
        435                 440                 445             


Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln 
    450                 455                 460                 


Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu 
465                 470                 475                 480 


Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu 
                485                 490                 495     


Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys 
            500                 505                 510         


Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln 
        515                 520                 525             


Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys 
    530                 535                 540                 


Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile 
545                 550                 555                 560 


Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu 
                565                 570                 575     


Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg 
            580                 585                 590         


Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu 
        595                 600                 605             


Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys 
    610                 615                 620                 


Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile 
625                 630                 635                 640 


Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp 
                645                 650                 655     


Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly 
            660                 665                 670         


Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg 
        675                 680                 685             


His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn 
    690                 695                 700                 


Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe 
705                 710                 715                 720 


Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe 
                725                 730                 735     


Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser 
            740                 745                 750         


Phe Ile Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn Leu Asn 
        755                 760                 765             


Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala Gly Arg 
    770                 775                 780                 


Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile Ile Cys 
785                 790                 795                 800 


Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn Leu Gln Leu Pro Leu Lys 
                805                 810                 815     


Thr Lys Ala Phe Phe Met Leu Asp Gly Ile Leu Ser Lys Tyr Phe Asp 
            820                 825                 830         


Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys Pro Val 
        835                 840                 845             


Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly Asn Asp 
    850                 855                 860                 


Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly Asn Lys 
865                 870                 875                 880 


Ser Cys Glu Asn Ile His Leu His Ser Glu Ala Val Leu Cys Thr Val 
                885                 890                 895     


Pro Asn Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu Trp Lys 
            900                 905                 910         


Gln Ala Ile Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln Pro Asp 
        915                 920                 925             


Gln Asn Phe Thr Gly Leu Ile Ala Gly Val Val Ser Ile Ser Thr Ala 
    930                 935                 940                 


Leu Leu Leu Leu Leu Gly Phe Phe Leu Trp Leu Lys Lys Arg Lys Gln 
945                 950                 955                 960 


Ile Lys Asp Leu Gly Ser Glu Leu Val Arg Tyr Asp Ala Arg Val His 
                965                 970                 975     


Thr Pro His Leu Asp Arg Leu Val Ser Ala Arg Ser Val Ser Pro Thr 
            980                 985                 990         


Thr Glu Met Val Ser Asn Glu Ser  Val Asp Tyr Arg Ala  Thr Phe Pro 
        995                 1000                 1005             


Glu Asp  Gln Phe Pro Asn Ser  Ser Gln Asn Gly Ser  Cys Arg Gln 
    1010                 1015                 1020             


Val Gln  Tyr Pro Leu Thr Asp  Met Ser Pro Ile Leu  Thr Ser Gly 
    1025                 1030                 1035             


Asp Ser  Asp Ile Ser Ser Pro  Leu Leu Gln Asn Thr  Val His Ile 
    1040                 1045                 1050             


Asp Leu  Ser Ala Leu Asn Pro  Glu Leu Val Gln Ala  Val Gln His 
    1055                 1060                 1065             


Val Val  Ile Gly Pro Ser Ser  Leu Ile Val His Phe  Asn Glu Val 
    1070                 1075                 1080             


Ile Gly  Arg Gly His Phe Gly  Cys Val Tyr His Gly  Thr Leu Leu 
    1085                 1090                 1095             


Asp Asn  Asp Gly Lys Lys Ile  His Cys Ala Val Lys  Ser Leu Asn 
    1100                 1105                 1110             


Arg Ile  Thr Asp Ile Gly Glu  Val Ser Gln Phe Leu  Thr Glu Gly 
    1115                 1120                 1125             


Ile Ile  Met Lys Asp Phe Ser  His Pro Asn Val Leu  Ser Leu Leu 
    1130                 1135                 1140             


Gly Ile  Cys Leu Arg Ser Glu  Gly Ser Pro Leu Val  Val Leu Pro 
    1145                 1150                 1155             


Tyr Met  Lys His Gly Asp Leu  Arg Asn Phe Ile Arg  Asn Glu Thr 
    1160                 1165                 1170             


His Asn  Pro Thr Val Lys Asp  Leu Ile Gly Phe Gly  Leu Gln Val 
    1175                 1180                 1185             


Ala Lys  Gly Met Lys Tyr Leu  Ala Ser Lys Lys Phe  Val His Arg 
    1190                 1195                 1200             


Asp Leu  Ala Ala Arg Asn Cys  Met Leu Asp Glu Lys  Phe Thr Val 
    1205                 1210                 1215             


Lys Val  Ala Asp Phe Gly Leu  Ala Arg Asp Met Tyr  Asp Lys Glu 
    1220                 1225                 1230             


Tyr Tyr  Ser Val His Asn Lys  Thr Gly Ala Lys Leu  Pro Val Lys 
    1235                 1240                 1245             


Trp Met  Ala Leu Glu Ser Leu  Gln Thr Gln Lys Phe  Thr Thr Lys 
    1250                 1255                 1260             


Ser Asp  Val Trp Ser Phe Gly  Val Leu Leu Trp Glu  Leu Met Thr 
    1265                 1270                 1275             


Arg Gly  Ala Pro Pro Tyr Pro  Asp Val Asn Thr Phe  Asp Ile Thr 
    1280                 1285                 1290             


Val Tyr  Leu Leu Gln Gly Arg  Arg Leu Leu Gln Pro  Glu Tyr Cys 
    1295                 1300                 1305             


Pro Asp  Pro Leu Tyr Glu Val  Met Leu Lys Cys Trp  His Pro Lys 
    1310                 1315                 1320             


Ala Glu  Met Arg Pro Ser Phe  Ser Glu Leu Val Ser  Arg Ile Ser 
    1325                 1330                 1335             


Ala Ile  Phe Ser Thr Phe Ile  Gly Glu His Tyr Val  His Val Asn 
    1340                 1345                 1350             


Ala Thr  Tyr Val Asn Val Lys  Cys Val Ala Pro Tyr  Pro Ser Leu 
    1355                 1360                 1365             


Leu Ser  Ser Glu Asp Asn Ala  Asp Asp Glu Val Asp  Thr Arg Pro 
    1370                 1375                 1380             


Ala Ser  Phe Trp Glu Thr Ser  
    1385                 1390 


<210>  8568
<211>  764
<212>  PRT
<213>  Homo Sapiens

<400>  8568

Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe 
1               5                   10                  15      


Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys 
            20                  25                  30          


Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala 
        35                  40                  45              


Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu 
    50                  55                  60                  


Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys 
65                  70                  75                  80  


Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe 
                85                  90                  95      


Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp 
            100                 105                 110         


Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp 
        115                 120                 125             


Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His 
    130                 135                 140                 


Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys 
145                 150                 155                 160 


Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val 
                165                 170                 175     


Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe 
            180                 185                 190         


Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp 
        195                 200                 205             


His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp 
    210                 215                 220                 


Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu 
225                 230                 235                 240 


Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn 
                245                 250                 255     


Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln 
            260                 265                 270         


Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu 
        275                 280                 285             


His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg 
    290                 295                 300                 


Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala 
305                 310                 315                 320 


Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser 
                325                 330                 335     


Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp 
            340                 345                 350         


Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys 
        355                 360                 365             


Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg 
    370                 375                 380                 


Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg 
385                 390                 395                 400 


Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr 
                405                 410                 415     


Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly 
            420                 425                 430         


Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly 
        435                 440                 445             


Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln 
    450                 455                 460                 


Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu 
465                 470                 475                 480 


Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu 
                485                 490                 495     


Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys 
            500                 505                 510         


Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln 
        515                 520                 525             


Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys 
    530                 535                 540                 


Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile 
545                 550                 555                 560 


Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu 
                565                 570                 575     


Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg 
            580                 585                 590         


Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu 
        595                 600                 605             


Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys 
    610                 615                 620                 


Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile 
625                 630                 635                 640 


Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp 
                645                 650                 655     


Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly 
            660                 665                 670         


Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg 
        675                 680                 685             


His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn 
    690                 695                 700                 


Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe 
705                 710                 715                 720 


Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe 
                725                 730                 735     


Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser 
            740                 745                 750         


Phe Ile Arg His Val Asn Ile Ala Leu Ile Gln Arg 
        755                 760                 


<210>  8569
<211>  190
<212>  PRT
<213>  Homo Sapiens

<400>  8569

Met Lys Ser Lys Ser Lys Ser Leu Ala Glu Cys Phe Pro Tyr Asp Lys 
1               5                   10                  15      


Pro Leu Ile Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val 
            20                  25                  30          


Leu Leu Phe Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala 
        35                  40                  45              


Leu Ala Lys Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn 
    50                  55                  60                  


Phe Thr Ala Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His 
65                  70                  75                  80  


Ile Phe Leu Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp 
                85                  90                  95      


Leu Gln Lys Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro 
            100                 105                 110         


Asp Cys Phe Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly 
        115                 120                 125             


Gly Val Trp Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr 
    130                 135                 140                 


Tyr Asp Asp Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys 
145                 150                 155                 160 


Gln Arg His Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu 
                165                 170                 175     


Val His Cys Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln 
            180                 185                 190 


<210>  8570
<211>  187
<212>  PRT
<213>  Homo Sapiens

<400>  8570

Leu Ala Pro Ala Ala Arg Ala Gly Tyr Ser Glu Glu Arg Cys Ser Trp 
1               5                   10                  15      


Arg Gly Ser Gly Leu Thr Gln Glu Pro Gly Ser Val Gly Gln Leu Ala 
            20                  25                  30          


Leu Ala Cys Ala Glu Gly Ala Val Glu Trp Leu Tyr Pro Ala Gly Ala 
        35                  40                  45              


Leu Arg Leu Thr Leu Gly Gly Pro Asp Pro Arg Ala Arg Pro Gly Ile 
    50                  55                  60                  


Ala Cys Leu Arg Pro Val Arg Pro Phe Ala Gly Ala Gln Val Phe Ala 
65                  70                  75                  80  


Glu Arg Ala Gly Gly Ala Leu Glu Leu Leu Leu Ala Glu Gly Pro Gly 
                85                  90                  95      


Pro Ala Gly Gly Arg Cys Val Arg Trp Gly Pro Arg Glu Arg Arg Ala 
            100                 105                 110         


Leu Phe Leu Gln Ala Thr Pro His Gln Asp Ile Ser Arg Arg Val Ala 
        115                 120                 125             


Ala Phe Arg Phe Glu Leu Arg Glu Asp Gly Arg Pro Glu Leu Pro Pro 
    130                 135                 140                 


Gln Ala His Gly Leu Gly Val Asp Gly Ala Cys Arg Pro Cys Ser Asp 
145                 150                 155                 160 


Ala Glu Leu Leu Leu Ala Ala Cys Thr Ser Asp Phe Gly Glu Cys Pro 
                165                 170                 175     


Arg His Gly Gly Ser Leu Glu Pro Ala Phe Pro 
            180                 185         


<210>  8571
<211>  69
<212>  PRT
<213>  Homo Sapiens

<400>  8571

Met Gly Phe Pro Ala Ala Ala Leu Leu Cys Ala Leu Cys Cys Gly Leu 
1               5                   10                  15      


Leu Ala Pro Ala Ala Arg Ala Gly Tyr Ser Glu Glu Arg Cys Ser Trp 
            20                  25                  30          


Arg Gly Arg Pro Arg Arg Thr Arg Thr Ser Ala Ala Ala Trp Pro Pro 
        35                  40                  45              


Ser Ala Leu Ser Cys Ala Arg Thr Gly Ala Pro Ser Cys Pro Arg Arg 
    50                  55                  60                  


Pro Thr Val Ser Ala 
65                  


<210>  8572
<211>  293
<212>  PRT
<213>  Homo Sapiens

<400>  8572

Met Gly Phe Pro Ala Ala Ala Leu Leu Cys Ala Leu Cys Cys Gly Leu 
1               5                   10                  15      


Leu Ala Pro Ala Ala Arg Ala Gly Tyr Ser Glu Glu Arg Cys Ser Trp 
            20                  25                  30          


Arg Gly Ser Gly Leu Thr Gln Glu Pro Gly Ser Val Gly Gln Leu Ala 
        35                  40                  45              


Leu Ala Cys Ala Glu Gly Ala Val Glu Trp Leu Tyr Pro Ala Gly Ala 
    50                  55                  60                  


Leu Arg Leu Thr Leu Gly Gly Pro Asp Pro Arg Ala Arg Pro Gly Ile 
65                  70                  75                  80  


Ala Cys Leu Arg Pro Val Arg Pro Phe Ala Gly Ala Gln Val Phe Ala 
                85                  90                  95      


Glu Arg Ala Gly Gly Ala Leu Glu Leu Leu Leu Ala Glu Gly Pro Gly 
            100                 105                 110         


Pro Ala Gly Gly Arg Cys Val Arg Trp Gly Pro Arg Glu Arg Arg Ala 
        115                 120                 125             


Leu Phe Leu Gln Ala Thr Pro His Gln Asp Ile Ser Arg Arg Val Ala 
    130                 135                 140                 


Ala Phe Arg Phe Glu Leu Arg Glu Asp Gly Arg Pro Glu Leu Pro Pro 
145                 150                 155                 160 


Gln Ala His Gly Leu Gly Val Asp Gly Ala Cys Arg Pro Cys Ser Asp 
                165                 170                 175     


Ala Glu Leu Leu Leu Ala Ala Cys Thr Ser Asp Phe Val Ile His Gly 
            180                 185                 190         


Ile Ile His Gly Val Thr His Asp Val Glu Leu Gln Glu Ser Val Ile 
        195                 200                 205             


Thr Val Val Ala Ala Arg Val Leu Arg Gln Thr Pro Pro Leu Phe Gln 
    210                 215                 220                 


Ala Gly Arg Ser Gly Asp Gln Gly Leu Thr Ser Ile Arg Thr Pro Leu 
225                 230                 235                 240 


Arg Cys Gly Val His Pro Gly Pro Gly Thr Phe Leu Phe Met Gly Trp 
                245                 250                 255     


Ser Arg Phe Gly Glu Ala Arg Leu Gly Cys Ala Pro Arg Phe Gln Glu 
            260                 265                 270         


Phe Arg Arg Ala Tyr Glu Ala Ala Arg Ala Ala His Leu His Pro Cys 
        275                 280                 285             


Glu Val Ala Leu His 
    290             


<210>  8573
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  8573

Met Leu Gly Cys Ile Cys Gln Met Gly Val Gln Glu Gly Gly Pro Gly 
1               5                   10                  15      


Gln Leu Ile Ala Arg His Gly Pro Gln Ala His Val Cys Val His Ser 
            20                  25                  30          


Cys Leu Gly Gly Ala Cys Arg Pro Cys Ser Asp Ala Glu Leu Leu Leu 
        35                  40                  45              


Ala Ala Cys Thr Ser Asp Phe Val Ile His Gly Ile Ile His Gly Val 
    50                  55                  60                  


Thr His Asp Val Glu Leu Gln Glu Ser Val Ile Thr Val Val Ala Ala 
65                  70                  75                  80  


Arg Val Leu Arg Gln Thr Pro Pro Leu Phe Gln Ala Gly Arg Ser Gly 
                85                  90                  95      


Asp Gln Gly Leu Thr Ser Ile Arg Thr Pro Leu Arg Cys Gly Val His 
            100                 105                 110         


Pro Gly Pro Gly Thr Phe Leu Phe Met Gly Trp Ser Arg Phe Gly Glu 
        115                 120                 125             


Ala Arg Leu Gly Cys Ala Pro Arg Phe Gln Glu Phe Arg Arg Ala Tyr 
    130                 135                 140                 


Glu Ala Ala Arg Ala Ala His Leu His Pro Cys Glu Val Ala Leu His 
145                 150                 155                 160 


<210>  8574
<211>  175
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8574

Xaa Ala Val Glu Trp Leu Tyr Pro Ala Gly Ala Leu Arg Leu Thr Leu 
1               5                   10                  15      


Gly Gly Pro Asp Pro Arg Ala Arg Pro Gly Ile Ala Cys Leu Arg Pro 
            20                  25                  30          


Val Arg Pro Phe Ala Gly Ala Gln Val Phe Ala Glu Arg Ala Gly Gly 
        35                  40                  45              


Ala Leu Glu Leu Leu Leu Ala Glu Gly Pro Gly Pro Ala Gly Gly Arg 
    50                  55                  60                  


Cys Val Arg Trp Gly Pro Arg Glu Arg Arg Ala Leu Phe Leu Gln Ala 
65                  70                  75                  80  


Thr Pro His Gln Asp Ile Ser Arg Arg Val Ala Ala Phe Arg Phe Glu 
                85                  90                  95      


Leu Arg Glu Asp Gly Arg Pro Glu Leu Pro Pro Gln Ala His Gly Leu 
            100                 105                 110         


Gly Val Asp Gly Ala Cys Arg Pro Cys Ser Asp Ala Glu Leu Leu Leu 
        115                 120                 125             


Ala Ala Cys Thr Ser Asp Phe Val Ile His Gly Ile Ile His Gly Val 
    130                 135                 140                 


Thr His Asp Val Glu Leu Gln Glu Ser Val Ile Thr Val Gly Gly Pro 
145                 150                 155                 160 


Thr Ala Leu Glu Val Met Gly Leu Ser Ile Arg Thr Leu Phe Thr 
                165                 170                 175 


<210>  8575
<211>  311
<212>  PRT
<213>  Homo Sapiens

<400>  8575

Met Arg Gly Ala Ala Arg Ala Ala Trp Gly Arg Ala Gly Gln Pro Trp 
1               5                   10                  15      


Pro Arg Pro Pro Ala Pro Gly Pro Pro Pro Pro Pro Leu Pro Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Ala Gly Leu Leu Gly Gly Ala Gly Ala Gln Tyr Ser 
        35                  40                  45              


Ser Asp Arg Cys Ser Trp Lys Gly Ser Gly Leu Thr His Glu Ala His 
    50                  55                  60                  


Arg Lys Glu Val Glu Gln Val Tyr Leu Arg Cys Ala Ala Gly Ala Val 
65                  70                  75                  80  


Glu Trp Met Tyr Pro Thr Gly Ala Leu Ile Val Asn Leu Arg Pro Asn 
                85                  90                  95      


Thr Phe Ser Pro Ala Arg His Leu Thr Val Cys Ile Arg Ser Phe Thr 
            100                 105                 110         


Asp Ser Ser Gly Ala Asn Ile Tyr Leu Glu Lys Thr Gly Glu Leu Arg 
        115                 120                 125             


Leu Leu Val Pro Asp Gly Asp Gly Arg Pro Gly Arg Val Gln Cys Phe 
    130                 135                 140                 


Gly Leu Glu Gln Gly Gly Leu Phe Val Glu Ala Thr Pro Gln Gln Asp 
145                 150                 155                 160 


Ile Gly Arg Arg Thr Thr Gly Phe Gln Tyr Glu Leu Val Arg Arg His 
                165                 170                 175     


Arg Ala Ser Asp Leu His Glu Leu Ser Ala Pro Cys Arg Pro Cys Ser 
            180                 185                 190         


Asp Thr Glu Val Leu Leu Ala Val Cys Thr Ser Asp Phe Ala Val Arg 
        195                 200                 205             


Gly Ser Ile Gln Gln Val Thr His Glu Pro Glu Arg Gln Asp Ser Ala 
    210                 215                 220                 


Ile His Leu Arg Val Ser Arg Leu Tyr Arg Gln Lys Ser Arg Val Phe 
225                 230                 235                 240 


Glu Pro Val Pro Glu Gly Asp Gly His Trp Gln Gly Arg Val Arg Thr 
                245                 250                 255     


Leu Leu Glu Cys Gly Val Arg Pro Gly His Gly Asp Phe Leu Phe Thr 
            260                 265                 270         


Gly His Met His Phe Gly Glu Ala Arg Leu Gly Cys Ala Pro Arg Phe 
        275                 280                 285             


Lys Asp Phe Gln Arg Met Tyr Arg Asp Ala Gln Glu Arg Gly Leu Asn 
    290                 295                 300                 


Pro Cys Glu Val Gly Thr Asp 
305                 310     


<210>  8576
<211>  229
<212>  PRT
<213>  Homo Sapiens

<400>  8576

Met Tyr Pro Thr Gly Ala Leu Ile Val Asn Leu Arg Pro Asn Thr Phe 
1               5                   10                  15      


Ser Pro Ala Arg His Leu Thr Val Cys Ile Arg Ser Phe Thr Asp Ser 
            20                  25                  30          


Ser Gly Ala Asn Ile Tyr Leu Glu Lys Thr Gly Glu Leu Arg Leu Leu 
        35                  40                  45              


Val Pro Asp Gly Asp Gly Arg Pro Gly Arg Val Gln Cys Phe Gly Leu 
    50                  55                  60                  


Glu Gln Gly Gly Leu Phe Val Glu Ala Thr Pro Gln Gln Asp Ile Gly 
65                  70                  75                  80  


Arg Arg Thr Thr Gly Phe Gln Tyr Glu Leu Val Arg Arg His Arg Ala 
                85                  90                  95      


Ser Asp Leu His Glu Leu Ser Ala Pro Cys Arg Pro Cys Ser Asp Thr 
            100                 105                 110         


Glu Val Leu Leu Ala Val Cys Thr Ser Asp Phe Ala Val Arg Gly Ser 
        115                 120                 125             


Ile Gln Gln Val Thr His Glu Pro Glu Arg Gln Asp Ser Ala Ile His 
    130                 135                 140                 


Leu Arg Val Ser Arg Leu Tyr Arg Gln Lys Ser Arg Val Phe Glu Pro 
145                 150                 155                 160 


Val Pro Glu Gly Asp Gly His Trp Gln Gly Arg Val Arg Thr Leu Leu 
                165                 170                 175     


Glu Cys Gly Val Arg Pro Gly His Gly Asp Phe Leu Phe Thr Gly His 
            180                 185                 190         


Met His Phe Gly Glu Ala Arg Leu Gly Cys Ala Pro Arg Phe Lys Asp 
        195                 200                 205             


Phe Gln Arg Met Tyr Arg Asp Ala Gln Glu Arg Gly Leu Asn Pro Cys 
    210                 215                 220                 


Glu Val Gly Thr Asp 
225                 


<210>  8577
<211>  229
<212>  PRT
<213>  Homo Sapiens

<400>  8577

Met Tyr Pro Thr Gly Ala Leu Ile Val Asn Leu Arg Pro Asn Thr Phe 
1               5                   10                  15      


Ser Pro Ala Arg His Leu Thr Val Cys Ile Arg Ser Phe Thr Asp Ser 
            20                  25                  30          


Ser Gly Ala Asn Ile Tyr Leu Glu Lys Thr Gly Glu Leu Arg Leu Leu 
        35                  40                  45              


Val Pro Asp Gly Asp Gly Arg Pro Gly Arg Val Gln Cys Phe Gly Leu 
    50                  55                  60                  


Glu Gln Gly Gly Leu Phe Val Glu Ala Thr Pro Gln Gln Asp Ile Gly 
65                  70                  75                  80  


Arg Arg Thr Thr Gly Phe Gln Tyr Glu Leu Val Arg Arg His Arg Ala 
                85                  90                  95      


Ser Asp Leu His Glu Leu Ser Ala Pro Cys Arg Pro Cys Ser Asp Thr 
            100                 105                 110         


Glu Val Leu Leu Ala Val Cys Thr Ser Asp Phe Ala Val Arg Gly Ser 
        115                 120                 125             


Ile Gln Gln Val Thr His Glu Pro Glu Arg Gln Asp Ser Ala Ile His 
    130                 135                 140                 


Leu Arg Val Ser Arg Leu Tyr Arg Gln Lys Ser Arg Val Phe Glu Pro 
145                 150                 155                 160 


Val Pro Glu Gly Asp Gly His Trp Gln Gly Arg Val Arg Thr Leu Leu 
                165                 170                 175     


Glu Cys Gly Val Arg Pro Gly His Gly Asp Phe Leu Phe Thr Gly His 
            180                 185                 190         


Met His Phe Gly Glu Ala Arg Leu Gly Cys Ala Pro Arg Phe Lys Asp 
        195                 200                 205             


Phe Gln Arg Met Tyr Arg Asp Ala Gln Glu Arg Gly Leu Asn Pro Cys 
    210                 215                 220                 


Glu Val Gly Thr Asp 
225                 


<210>  8578
<211>  90
<212>  PRT
<213>  Homo Sapiens

<400>  8578

Arg Thr Ala Val Arg Gly Ser Ile Gln Gln Val Thr His Glu Pro Glu 
1               5                   10                  15      


Arg Gln Asp Ser Ala Ile His Leu Arg Val Ser Arg Leu Tyr Arg Gln 
            20                  25                  30          


Lys Ser Arg Val Phe Glu Pro Val Pro Glu Gly Asp Gly His Trp Gln 
        35                  40                  45              


Gly Arg Val Arg Thr Leu Leu Glu Cys Gly Ala Arg Leu Gly Cys Ala 
    50                  55                  60                  


Pro Arg Phe Lys Asp Phe Gln Arg Met Tyr Arg Asp Ala Gln Glu Arg 
65                  70                  75                  80  


Gly Leu Asn Pro Cys Glu Val Gly Thr Asp 
                85                  90  


<210>  8579
<211>  456
<212>  PRT
<213>  Homo Sapiens

<400>  8579

Met Ala Ala Ala Leu Lys Cys Leu Leu Thr Leu Gly Arg Trp Cys Pro 
1               5                   10                  15      


Gly Leu Gly Val Ala Pro Gln Ala Arg Ala Leu Ala Ala Leu Val Pro 
            20                  25                  30          


Gly Val Thr Gln Val Asp Asn Lys Ser Gly Phe Leu Gln Lys Arg Pro 
        35                  40                  45              


His Arg Gln His Pro Gly Ile Leu Lys Leu Pro His Val Arg Leu Pro 
    50                  55                  60                  


Gln Ala Leu Ala Asn Gly Ala Gln Leu Leu Leu Leu Gly Ser Ala Gly 
65                  70                  75                  80  


Pro Thr Met Glu Asn Gln Val Gln Thr Leu Thr Ser Tyr Leu Trp Ser 
                85                  90                  95      


Arg His Leu Pro Val Glu Pro Glu Glu Leu Gln Arg Arg Ala Arg His 
            100                 105                 110         


Leu Glu Lys Lys Phe Leu Glu Asn Pro Asp Leu Ser Gln Thr Glu Glu 
        115                 120                 125             


Lys Leu Arg Gly Ala Val Leu His Ala Leu Arg Lys Thr Thr Tyr His 
    130                 135                 140                 


Trp Gln Glu Leu Ser Tyr Thr Glu Gly Leu Ser Leu Val Tyr Met Ala 
145                 150                 155                 160 


Ala Arg Leu Asp Gly Gly Phe Ala Ala Val Ser Arg Ala Phe His Glu 
                165                 170                 175     


Ile Arg Ala Arg Asn Pro Ala Phe Gln Pro Gln Thr Leu Met Asp Phe 
            180                 185                 190         


Gly Ser Gly Thr Gly Ser Val Thr Trp Ala Ala His Ser Ile Trp Gly 
        195                 200                 205             


Gln Ser Leu Arg Glu Tyr Met Cys Val Asp Arg Ser Ala Ala Met Leu 
    210                 215                 220                 


Val Leu Ala Glu Lys Leu Leu Lys Gly Gly Ser Glu Ser Gly Glu Pro 
225                 230                 235                 240 


Tyr Ile Pro Gly Val Phe Phe Arg Gln Phe Leu Pro Val Ser Pro Lys 
                245                 250                 255     


Val Gln Phe Asp Val Val Val Ser Ala Phe Ser Leu Ser Glu Leu Pro 
            260                 265                 270         


Ser Lys Ala Asp Arg Thr Glu Val Val Gln Thr Leu Trp Arg Lys Thr 
        275                 280                 285             


Gly His Phe Leu Val Leu Val Glu Asn Gly Thr Lys Ala Gly His Ser 
    290                 295                 300                 


Leu Leu Met Asp Ala Arg Asp Leu Val Leu Lys Gly Lys Glu Lys Ser 
305                 310                 315                 320 


Pro Leu Asp Pro Arg Pro Gly Phe Val Phe Ala Pro Cys Pro His Glu 
                325                 330                 335     


Leu Pro Cys Pro Gln Leu Thr Asn Leu Ala Cys Ser Phe Ser Gln Ala 
            340                 345                 350         


Tyr His Pro Ile Pro Phe Ser Trp Asn Lys Lys Pro Lys Glu Glu Lys 
        355                 360                 365             


Phe Ser Met Val Ile Leu Ala Arg Gly Ser Pro Glu Glu Ala His Arg 
    370                 375                 380                 


Trp Pro Arg Ile Thr Gln Pro Val Leu Lys Arg Pro Arg His Val His 
385                 390                 395                 400 


Cys His Leu Cys Cys Pro Asp Gly His Met Gln His Ala Val Leu Thr 
                405                 410                 415     


Ala Arg Arg His Gly Arg Asp Leu Tyr Arg Cys Ala Arg Val Ser Ser 
            420                 425                 430         


Trp Gly Asp Leu Leu Pro Val Leu Thr Pro Ser Ala Phe Pro Pro Ser 
        435                 440                 445             


Thr Ala Gln Asp Pro Ser Glu Ser 
    450                 455     


<210>  8580
<211>  478
<212>  PRT
<213>  Homo Sapiens

<400>  8580

Met Ala Ala Ala Leu Lys Cys Leu Leu Thr Leu Gly Arg Trp Cys Pro 
1               5                   10                  15      


Gly Leu Gly Val Ala Pro Gln Ala Arg Ala Leu Ala Ala Leu Val Pro 
            20                  25                  30          


Gly Val Thr Gln Val Asp Asn Lys Ser Gly Phe Leu Gln Lys Arg Pro 
        35                  40                  45              


His Arg Gln His Pro Gly Ile Leu Lys Leu Pro His Val Arg Leu Pro 
    50                  55                  60                  


Gln Ala Leu Ala Asn Gly Ala Gln Leu Leu Leu Leu Gly Ser Ala Gly 
65                  70                  75                  80  


Pro Thr Met Glu Asn Gln Val Gln Thr Leu Thr Ser Tyr Leu Trp Ser 
                85                  90                  95      


Arg His Leu Pro Val Glu Pro Glu Glu Leu Gln Arg Arg Ala Arg His 
            100                 105                 110         


Leu Glu Lys Lys Phe Leu Glu Asn Pro Asp Leu Ser Gln Thr Glu Glu 
        115                 120                 125             


Lys Leu Arg Gly Ala Val Leu His Ala Leu Arg Lys Thr Thr Tyr His 
    130                 135                 140                 


Trp Gln Glu Leu Ser Tyr Thr Glu Gly Leu Ser Leu Val Tyr Met Ala 
145                 150                 155                 160 


Ala Arg Leu Asp Gly Gly Phe Ala Ala Val Ser Arg Ala Phe His Glu 
                165                 170                 175     


Ile Arg Ala Arg Asn Pro Ala Phe Gln Pro Gln Thr Leu Met Asp Phe 
            180                 185                 190         


Gly Ser Gly Thr Gly Ser Val Thr Trp Ala Ala His Ser Ile Trp Gly 
        195                 200                 205             


Gln Ser Leu Arg Glu Tyr Met Cys Val Asp Arg Ser Ala Ala Met Leu 
    210                 215                 220                 


Val Leu Ala Glu Lys Leu Leu Lys Gly Gly Ser Glu Ser Gly Glu Pro 
225                 230                 235                 240 


Tyr Ile Pro Gly Val Phe Phe Arg Gln Phe Leu Pro Val Ser Pro Lys 
                245                 250                 255     


Val Gln Phe Asp Val Val Val Ser Ala Phe Ser Leu Ser Glu Leu Pro 
            260                 265                 270         


Ser Lys Ala Asp Arg Thr Glu Val Val Gln Thr Leu Trp Arg Lys Thr 
        275                 280                 285             


Gly His Phe Leu Val Leu Val Glu Asn Gly Thr Lys Ala Gly His Ser 
    290                 295                 300                 


Leu Leu Met Asp Ala Arg Asp Leu Val Leu Lys Gly Lys Glu Lys Ser 
305                 310                 315                 320 


Pro Leu Asp Pro Arg Pro Gly Phe Val Phe Ala Pro Cys Pro His Glu 
                325                 330                 335     


Leu Pro Cys Pro Gln Leu Thr Asn Leu Ala Cys Ser Phe Ser Gln Ala 
            340                 345                 350         


Tyr His Pro Ile Pro Phe Ser Trp Asn Lys Lys Pro Lys Glu Glu Lys 
        355                 360                 365             


Phe Ser Met Val Ile Leu Ala Arg Gly Ser Pro Glu Glu Ala His Arg 
    370                 375                 380                 


Trp Pro Arg Ile Thr Gln Pro Val Leu Lys Arg Pro Arg His Val His 
385                 390                 395                 400 


Cys His Leu Cys Cys Pro Asp Gly His Met Gln His Ala Val Leu Thr 
                405                 410                 415     


Ala Arg Arg His Gly Arg Tyr Gly Gly Cys Asp Gln Asn Gln Trp Asp 
            420                 425                 430         


Val Ala Gly Ser Cys Ser Pro Arg Gln His Leu Phe Pro Gln Gly Phe 
        435                 440                 445             


Val Ser Leu Cys Pro Cys Gln Leu Leu Gly Arg Ser Phe Thr Cys Ala 
    450                 455                 460                 


Tyr Ser Val Cys Val Ser Ser Ile Tyr Gly Ser Gly Ser Leu 
465                 470                 475             


<210>  8581
<211>  447
<212>  PRT
<213>  Homo Sapiens

<400>  8581

Met Ala Ala Ala Leu Lys Cys Leu Leu Thr Leu Gly Arg Trp Cys Pro 
1               5                   10                  15      


Gly Leu Gly Val Ala Pro Gln Ala Arg Ala Leu Ala Ala Leu Val Pro 
            20                  25                  30          


Gly Val Thr Gln Val Asp Asn Lys Ser Gly Phe Leu Gln Lys Arg Pro 
        35                  40                  45              


His Arg Gln His Pro Gly Ile Leu Lys Leu Pro His Val Arg Leu Pro 
    50                  55                  60                  


Gln Ala Leu Ala Asn Gly Ala Gln Leu Leu Leu Leu Gly Ser Ala Gly 
65                  70                  75                  80  


Pro Thr Met Glu Asn Gln Val Gln Thr Leu Thr Ser Tyr Leu Trp Ser 
                85                  90                  95      


Arg His Leu Pro Val Glu Pro Glu Glu Leu Gln Arg Arg Ala Arg His 
            100                 105                 110         


Leu Glu Lys Lys Phe Leu Glu Asn Pro Asp Leu Ser Gln Thr Glu Glu 
        115                 120                 125             


Lys Leu Arg Gly Ala Val Leu His Ala Leu Arg Lys Thr Thr Tyr His 
    130                 135                 140                 


Trp Gln Glu Leu Ser Tyr Thr Glu Gly Leu Ser Leu Val Tyr Met Ala 
145                 150                 155                 160 


Ala Arg Leu Asp Gly Gly Phe Ala Ala Val Ser Arg Ala Phe His Glu 
                165                 170                 175     


Ile Arg Ala Arg Asn Pro Ala Phe Gln Pro Gln Thr Leu Met Asp Phe 
            180                 185                 190         


Gly Ser Gly Thr Gly Ser Val Thr Trp Ala Ala His Ser Ile Trp Gly 
        195                 200                 205             


Gln Ser Leu Arg Glu Tyr Met Cys Val Asp Arg Ser Ala Ala Met Leu 
    210                 215                 220                 


Val Leu Ala Glu Lys Leu Leu Lys Gly Gly Ser Glu Ser Gly Glu Pro 
225                 230                 235                 240 


Tyr Ile Pro Gly Val Phe Phe Arg Gln Phe Leu Pro Val Ser Pro Lys 
                245                 250                 255     


Val Gln Phe Asp Val Val Val Ser Ala Phe Ser Leu Ser Glu Leu Pro 
            260                 265                 270         


Ser Lys Ala Asp Arg Thr Glu Val Val Gln Thr Leu Trp Arg Lys Thr 
        275                 280                 285             


Gly His Phe Leu Val Leu Val Glu Asn Gly Thr Lys Ala Gly His Ser 
    290                 295                 300                 


Leu Leu Met Asp Ala Arg Asp Leu Val Leu Lys Gly Lys Glu Lys Ser 
305                 310                 315                 320 


Pro Leu Asp Pro Arg Pro Gly Phe Val Phe Ala Pro Cys Pro His Glu 
                325                 330                 335     


Leu Pro Cys Pro Gln Leu Thr Asn Leu Ala Cys Ser Phe Ser Gln Ala 
            340                 345                 350         


Tyr His Pro Ile Pro Phe Ser Trp Asn Lys Lys Pro Lys Glu Glu Lys 
        355                 360                 365             


Phe Ser Met Val Ile Leu Ala Arg Gly Ser Pro Glu Glu Ala His Arg 
    370                 375                 380                 


Trp Pro Arg Ile Thr Gln Pro Val Leu Lys Arg Pro Arg His Val His 
385                 390                 395                 400 


Cys His Leu Cys Cys Pro Asp Gly His Met Gln His Ala Val Leu Thr 
                405                 410                 415     


Ala Arg Arg His Gly Ser Ser Trp Gly Asp Leu Leu Pro Val Leu Thr 
            420                 425                 430         


Pro Ser Ala Phe Pro Pro Ser Thr Ala Gln Asp Pro Ser Glu Ser 
        435                 440                 445         


<210>  8582
<211>  158
<212>  PRT
<213>  Homo Sapiens

<400>  8582

Met Ala Ala Ala Leu Lys Cys Leu Leu Thr Leu Gly Arg Trp Cys Pro 
1               5                   10                  15      


Gly Leu Gly Val Ala Pro Gln Ala Arg Ala Leu Ala Ala Leu Val Pro 
            20                  25                  30          


Gly Val Thr Gln Val Asp Asn Lys Ser Gly Phe Leu Gln Lys Arg Pro 
        35                  40                  45              


His Arg Gln His Pro Gly Ile Leu Lys Leu Pro His Val Arg Leu Pro 
    50                  55                  60                  


Gln Ala Leu Ala Asn Gly Ala Gln Leu Leu Leu Leu Gly Ser Ala Gly 
65                  70                  75                  80  


Pro Thr Met Glu Asn Gln Val Gln Thr Leu Thr Ser Tyr Leu Trp Ser 
                85                  90                  95      


Arg His Leu Pro Val Glu Pro Glu Glu Leu Gln Arg Arg Ala Arg His 
            100                 105                 110         


Leu Glu Lys Lys Phe Leu Glu Asn Pro Gly Pro Asp Phe Gln Ser Leu 
        115                 120                 125             


Phe Ser Pro Gln Thr Tyr Leu Arg Gln Arg Arg Asn Phe Val Glu Gln 
    130                 135                 140                 


Cys Tyr Thr His Tyr Val Lys Leu Pro Thr Ile Gly Lys Asn 
145                 150                 155             


<210>  8583
<211>  158
<212>  PRT
<213>  Homo Sapiens

<400>  8583

Met Ala Ala Ala Leu Lys Cys Leu Leu Thr Leu Gly Arg Trp Cys Pro 
1               5                   10                  15      


Gly Leu Gly Val Ala Pro Gln Ala Arg Ala Leu Ala Ala Leu Val Pro 
            20                  25                  30          


Gly Val Thr Gln Val Asp Asn Lys Ser Gly Phe Leu Gln Lys Arg Pro 
        35                  40                  45              


His Arg Gln His Pro Gly Ile Leu Lys Leu Pro His Val Arg Leu Pro 
    50                  55                  60                  


Gln Ala Leu Ala Asn Gly Ala Gln Leu Leu Leu Leu Gly Ser Ala Gly 
65                  70                  75                  80  


Pro Thr Met Glu Asn Gln Val Gln Thr Leu Thr Ser Tyr Leu Trp Ser 
                85                  90                  95      


Arg His Leu Pro Val Glu Pro Glu Glu Leu Gln Arg Arg Ala Arg His 
            100                 105                 110         


Leu Glu Lys Lys Phe Leu Glu Asn Pro Gly Pro Asp Phe Gln Ser Leu 
        115                 120                 125             


Phe Ser Pro Gln Thr Tyr Leu Arg Gln Arg Arg Asn Phe Val Glu Gln 
    130                 135                 140                 


Cys Tyr Thr His Tyr Val Lys Leu Pro Thr Ile Gly Lys Asn 
145                 150                 155             


<210>  8584
<211>  158
<212>  PRT
<213>  Homo Sapiens

<400>  8584

Met Ala Ala Ala Leu Lys Cys Leu Leu Thr Leu Gly Arg Trp Cys Pro 
1               5                   10                  15      


Gly Leu Gly Val Ala Pro Gln Ala Arg Ala Leu Ala Ala Leu Val Pro 
            20                  25                  30          


Gly Val Thr Gln Val Asp Asn Lys Ser Gly Phe Leu Gln Lys Arg Pro 
        35                  40                  45              


His Arg Gln His Pro Gly Ile Leu Lys Leu Pro His Val Arg Leu Pro 
    50                  55                  60                  


Gln Ala Leu Ala Asn Gly Ala Gln Leu Leu Leu Leu Gly Ser Ala Gly 
65                  70                  75                  80  


Pro Thr Met Glu Asn Gln Val Gln Thr Leu Thr Ser Tyr Leu Trp Ser 
                85                  90                  95      


Arg His Leu Pro Val Glu Pro Glu Glu Leu Gln Arg Arg Ala Arg His 
            100                 105                 110         


Leu Glu Lys Lys Phe Leu Glu Asn Pro Gly Pro Asp Phe Gln Ser Leu 
        115                 120                 125             


Phe Ser Pro Gln Thr Tyr Leu Arg Gln Arg Arg Asn Phe Val Glu Gln 
    130                 135                 140                 


Cys Tyr Thr His Tyr Val Lys Leu Pro Thr Ile Gly Lys Asn 
145                 150                 155             


<210>  8585
<211>  102
<212>  PRT
<213>  Homo Sapiens

<400>  8585

Met Glu Asn Gln Val Gln Thr Leu Thr Ser Tyr Leu Trp Ser Arg His 
1               5                   10                  15      


Leu Pro Val Glu Pro Glu Glu Leu Gln Arg Arg Ala Arg His Leu Glu 
            20                  25                  30          


Lys Lys Phe Leu Glu Asn Pro Asp Leu Ser Gln Thr Glu Glu Lys Leu 
        35                  40                  45              


Arg Gly Ala Val Leu His Ala Leu Arg Lys Thr Thr Tyr His Trp Gln 
    50                  55                  60                  


Glu Leu Ser Tyr Thr Glu Gly Leu Ser Leu Val Tyr Met Ala Ala Arg 
65                  70                  75                  80  


Leu Asp Gly Gly Phe Ala Ala Val Ser Arg Ala Phe His Glu Ile Arg 
                85                  90                  95      


Ala Arg Asn Pro Ala Phe 
            100         


<210>  8586
<211>  140
<212>  PRT
<213>  Homo Sapiens

<400>  8586

Met Glu Asn Gln Val Gln Thr Leu Thr Ser Tyr Leu Trp Ser Arg His 
1               5                   10                  15      


Leu Pro Val Glu Pro Glu Glu Leu Gln Arg Arg Ala Arg His Leu Glu 
            20                  25                  30          


Lys Lys Phe Leu Glu Asn Pro Asp Leu Ser Gln Thr Glu Glu Lys Leu 
        35                  40                  45              


Arg Gly Ala Val Leu His Ala Leu Arg Lys Thr Thr Tyr His Trp Gln 
    50                  55                  60                  


Glu Leu Ser Tyr Thr Glu Gly Leu Ser Leu Val Tyr Met Ala Ala Arg 
65                  70                  75                  80  


Leu Asp Gly Gly Phe Ala Ala Val Ser Arg Ala Phe His Glu Ile Arg 
                85                  90                  95      


Ala Arg Asn Pro Ala Phe Gln Pro Gln Thr Leu Met Asp Phe Gly Ser 
            100                 105                 110         


Gly Thr Gly Ser Val Thr Trp Ala Ala His Ser Ile Trp Gly Gln Ser 
        115                 120                 125             


Leu Arg Glu Tyr Met Cys Val Asp Arg Ser Ala Ala 
    130                 135                 140 


<210>  8587
<211>  174
<212>  PRT
<213>  Homo Sapiens

<400>  8587

Met Glu Asn Gln Val Gln Thr Leu Thr Ser Tyr Leu Trp Ser Arg His 
1               5                   10                  15      


Leu Pro Val Glu Pro Glu Glu Leu Gln Arg Arg Ala Arg His Leu Glu 
            20                  25                  30          


Lys Lys Phe Leu Glu Asn Pro Asp Leu Ser Gln Thr Glu Glu Lys Leu 
        35                  40                  45              


Arg Gly Ala Val Leu His Ala Leu Arg Lys Thr Thr Tyr His Trp Gln 
    50                  55                  60                  


Glu Leu Ser Tyr Thr Glu Gly Leu Ser Leu Val Tyr Met Ala Ala Arg 
65                  70                  75                  80  


Leu Asp Gly Gly Phe Ala Ala Val Ser Arg Ala Phe His Glu Ile Arg 
                85                  90                  95      


Ala Arg Asn Pro Ala Phe Gln Pro Gln Thr Leu Met Asp Phe Gly Ser 
            100                 105                 110         


Gly Thr Gly Ser Val Thr Trp Ala Ala His Ser Ile Trp Gly Gln Ser 
        115                 120                 125             


Leu Arg Glu Tyr Met Cys Val Asp Arg Ser Ala Ala Met Leu Val Leu 
    130                 135                 140                 


Ala Glu Lys Leu Leu Lys Gly Gly Ser Glu Ser Gly Glu Pro Tyr Ile 
145                 150                 155                 160 


Pro Gly Val Phe Phe Arg Gln Phe Leu Pro Val Ser Pro Lys 
                165                 170                 


<210>  8588
<211>  186
<212>  PRT
<213>  Homo Sapiens

<400>  8588

Met Val Pro Arg Pro Trp Ser Gly Ser Pro Gly Pro Gly Glu Cys Leu 
1               5                   10                  15      


His Ser Leu Leu Ser Glu Arg Leu Trp Ile Cys Arg Asp Ile Ser Ala 
            20                  25                  30          


Gln Arg Arg Ser Ala Pro Gly Ser Pro Arg Pro Ser Asp Cys Gln Gln 
        35                  40                  45              


Leu Ser Phe Leu Pro Gly Asn Gln Pro Thr Phe Leu Cys Leu Gln Ala 
    50                  55                  60                  


Leu Ala Ala Leu Val Pro Gly Val Thr Gln Val Asp Asn Lys Ser Gly 
65                  70                  75                  80  


Phe Leu Gln Lys Arg Pro His Arg Gln His Pro Gly Ile Leu Lys Leu 
                85                  90                  95      


Pro His Val Arg Leu Pro Gln Ala Leu Ala Asn Gly Ala Gln Leu Leu 
            100                 105                 110         


Leu Leu Gly Ser Ala Gly Pro Thr Met Glu Asn Gln Val Gln Thr Leu 
        115                 120                 125             


Thr Ser Tyr Leu Trp Ser Arg His Leu Pro Val Glu Pro Glu Glu Leu 
    130                 135                 140                 


Gln Arg Arg Ala Arg His Leu Glu Lys Lys Phe Leu Glu Asn Pro Asp 
145                 150                 155                 160 


Leu Ser Gln Thr Glu Glu Lys Leu Arg Gly Ala Val Leu His Ala Leu 
                165                 170                 175     


Arg Lys Thr Thr Tyr His Trp Gln Glu Leu 
            180                 185     


<210>  8589
<211>  123
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8589

Xaa Pro Gly Phe Val Phe Ala Pro Cys Pro His Glu Leu Pro Cys Pro 
1               5                   10                  15      


Gln Leu Thr Asn Leu Ala Cys Ser Phe Ser Gln Ala Tyr His Pro Ile 
            20                  25                  30          


Pro Phe Ser Trp Asn Lys Lys Pro Lys Glu Glu Lys Phe Ser Met Val 
        35                  40                  45              


Ile Leu Ala Arg Gly Ser Pro Glu Glu Ala His Arg Trp Pro Arg Ile 
    50                  55                  60                  


Thr Gln Pro Val Leu Lys Arg Pro Arg His Val His Cys His Leu Cys 
65                  70                  75                  80  


Cys Pro Asp Gly His Met Gln His Ala Val Leu Thr Ala Arg Arg His 
                85                  90                  95      


Gly Ser Ser Trp Gly Asp Leu Leu Pro Val Leu Thr Pro Ser Ala Phe 
            100                 105                 110         


Pro Pro Ser Thr Ala Gln Asp Pro Ser Glu Ser 
        115                 120             


<210>  8590
<211>  366
<212>  PRT
<213>  Homo Sapiens

<400>  8590

Met Ala Arg Glu Arg Pro Pro Gly Arg Gly Cys Gly Val Leu Arg Arg 
1               5                   10                  15      


Cys Leu Leu Gly Ala Val Leu Leu Phe Gly Leu Arg Leu Cys Ala Glu 
            20                  25                  30          


Leu Arg Arg Ala Gly Pro Gly Ser Pro Thr Arg Ser Ala Pro Pro Gly 
        35                  40                  45              


Pro Ala Trp Arg Pro Pro Gly Pro His Leu Pro Pro Ala Pro Gly Gln 
    50                  55                  60                  


Pro Arg Gly Ala Ser Arg Arg Gln Val Thr Tyr Val Arg Ser Gly Arg 
65                  70                  75                  80  


Arg Ala Pro Pro Gly Gly Gly Gly Ser Gly Thr Pro Glu Pro Gly Cys 
                85                  90                  95      


Cys Ala Pro Arg Gly Arg Pro Arg Arg Lys Gly Pro Arg Trp His Ile 
            100                 105                 110         


Asp Leu Gln Pro Trp Ala Gly Ser Ala Gln Ser Leu Asp Glu Glu Ala 
        115                 120                 125             


Trp Arg Phe Leu Arg Tyr Ile Ser Thr Thr Gln Ile Ala Cys Asn His 
    130                 135                 140                 


Met Asn Thr Asp Ser Leu Ala Thr Asp Ser Ser Pro Thr His Lys Pro 
145                 150                 155                 160 


Trp Ser Val Cys Leu Asp Asp Arg Phe Asn Leu Ala His Gln Ile Arg 
                165                 170                 175     


Asn Lys Gln Cys Arg Leu Tyr Ser Leu Gly Leu Gly Ser Asp Asp Thr 
            180                 185                 190         


His Phe Glu Val Ser Met Ala Asn Asn Gly Cys Glu Val His Arg Phe 
        195                 200                 205             


Asp Pro Ser Val Lys Ser Ala His Ile Leu Glu Ser Gln His Leu Trp 
    210                 215                 220                 


Tyr His Arg Leu Ser Ile Asp Trp Arg Asp Pro His Pro Ala Val Ala 
225                 230                 235                 240 


Ala Gln Lys Pro His Ser Asn Thr Arg Lys Leu Gly Ser Ile Leu Asn 
                245                 250                 255     


Glu Phe Gly His His Lys Ile Asp Val Leu Lys Ala Asp Leu Glu Ser 
            260                 265                 270         


Ala Glu Trp Lys Val Leu Glu Asn Leu Ile Leu Glu Asp Val Leu Glu 
        275                 280                 285             


Gln Ile Gly Gln Leu Ile Phe Glu Ile His Leu His Trp Pro Gly Phe 
    290                 295                 300                 


Glu Val Ser Gly Ser Asp Ser Ser Val Val Arg Phe Trp Tyr Ser Leu 
305                 310                 315                 320 


Leu Lys Glu Leu Glu Gln Lys Asp Phe Arg Leu Phe His Ser Tyr Lys 
                325                 330                 335     


Asp Leu Ser Lys Pro Gln Leu Phe Leu Lys Lys Asp Ile Phe Asn Ala 
            340                 345                 350         


Ser Ser Cys Tyr Thr Leu Ser Trp Val Asn Thr Arg Trp Lys 
        355                 360                 365     


<210>  8591
<211>  244
<212>  PRT
<213>  Homo Sapiens

<400>  8591

Met Asp Ile Leu Val Pro Leu Leu Gln Leu Leu Val Leu Leu Leu Thr 
1               5                   10                  15      


Leu Pro Leu His Leu Met Ala Leu Leu Gly Cys Trp Gln Pro Leu Cys 
            20                  25                  30          


Lys Ser Tyr Phe Pro Tyr Leu Met Ala Val Leu Thr Pro Lys Ser Asn 
        35                  40                  45              


Arg Lys Met Glu Ser Lys Lys Arg Glu Leu Phe Ser Gln Ile Lys Gly 
    50                  55                  60                  


Leu Thr Gly Ala Ser Gly Lys Val Ala Leu Leu Glu Leu Gly Cys Gly 
65                  70                  75                  80  


Thr Gly Ala Asn Phe Gln Phe Tyr Pro Pro Gly Cys Arg Val Thr Cys 
                85                  90                  95      


Leu Asp Pro Asn Pro His Phe Glu Lys Phe Leu Thr Lys Ser Met Ala 
            100                 105                 110         


Glu Asn Arg His Leu Gln Tyr Glu Arg Phe Val Val Ala Pro Gly Glu 
        115                 120                 125             


Asp Met Arg Gln Leu Ala Asp Gly Ser Met Asp Val Val Val Cys Thr 
    130                 135                 140                 


Leu Val Leu Cys Ser Val Gln Ser Pro Arg Lys Val Leu Gln Glu Val 
145                 150                 155                 160 


Arg Arg Val Leu Arg Pro Gly Gly Val Leu Phe Phe Trp Glu His Val 
                165                 170                 175     


Ala Glu Pro Tyr Gly Ser Trp Ala Phe Met Trp Gln Gln Val Phe Glu 
            180                 185                 190         


Pro Thr Trp Lys His Ile Gly Asp Gly Cys Cys Leu Thr Arg Glu Thr 
        195                 200                 205             


Trp Lys Asp Leu Glu Asn Ala Gln Phe Ser Glu Ile Gln Met Glu Arg 
    210                 215                 220                 


Gln Pro Pro Pro Leu Lys Trp Leu Pro Val Gly Pro His Ile Met Gly 
225                 230                 235                 240 


Lys Ala Val Lys 
                


<210>  8592
<211>  276
<212>  PRT
<213>  Homo Sapiens

<400>  8592

Met Asp Ile Leu Val Pro Leu Leu Gln Leu Leu Val Leu Leu Leu Thr 
1               5                   10                  15      


Leu Pro Leu His Leu Met Ala Leu Leu Gly Cys Trp Gln Pro Leu Cys 
            20                  25                  30          


Lys Ser Tyr Phe Pro Tyr Leu Met Ala Val Leu Thr Pro Lys Ser Asn 
        35                  40                  45              


Arg Lys Met Glu Ser Lys Lys Arg Glu Leu Phe Ser Gln Ile Lys Gly 
    50                  55                  60                  


Leu Thr Gly Ala Ser Gly Lys Val Ala Leu Leu Glu Leu Gly Cys Gly 
65                  70                  75                  80  


Thr Gly Ala Asn Phe Gln Phe Tyr Pro Pro Gly Cys Arg Val Thr Cys 
                85                  90                  95      


Leu Asp Pro Asn Pro His Phe Glu Lys Phe Leu Thr Lys Ser Met Ala 
            100                 105                 110         


Glu Asn Arg His Leu Gln Tyr Glu Arg Phe Val Val Ala Pro Gly Glu 
        115                 120                 125             


Asp Met Arg Gln Leu Ala Asp Gly Ser Met Asp Val Val Val Cys Thr 
    130                 135                 140                 


Leu Val Leu Cys Ser Val Gln Ser Pro Arg Lys Val Leu Gln Glu Val 
145                 150                 155                 160 


Arg Arg Val Leu Arg Pro Gly Gly Val Leu Phe Phe Trp Glu His Val 
                165                 170                 175     


Ala Glu Pro Tyr Gly Ser Trp Ala Phe Met Trp Gln Gln Val Phe Glu 
            180                 185                 190         


Pro Thr Trp Lys His Ile Gly Asp Gly Cys Cys Leu Thr Arg Glu Thr 
        195                 200                 205             


Trp Lys Asp Leu Glu Asn Ala Gln Phe Ser Glu Ile Gln Met Glu Arg 
    210                 215                 220                 


Gln Pro Pro Pro Leu Lys Trp Leu Pro Val Gly Pro His Ile Met Gly 
225                 230                 235                 240 


Lys Ala Val Lys Ser Phe Pro Ser Ser Lys Ala Leu Ile Cys Ser Phe 
                245                 250                 255     


Pro Ser Leu Gln Leu Glu Gln Ala Thr His Gln Pro Ile Tyr Leu Pro 
            260                 265                 270         


Leu Arg Gly Thr 
        275     


<210>  8593
<211>  243
<212>  PRT
<213>  Homo Sapiens

<400>  8593

Met Asp Arg Lys Thr Thr Ser Trp Asp Thr Lys Phe Tyr Glu Lys Trp 
1               5                   10                  15      


Tyr Val Cys Asn Arg Glu Lys Leu Cys Glu Ser Leu Gln Ala Val Phe 
            20                  25                  30          


Val Gln Ser Tyr Leu Asp Gln Gly Thr Gln Ile Phe Leu Asn Asn Ser 
        35                  40                  45              


Ile Glu Lys Ser Gly Trp Leu Phe Ile Gln Leu Tyr His Ser Phe Val 
    50                  55                  60                  


Ser Ser Val Phe Ser Leu Phe Met Ser Arg Thr Ser Ile Asn Gly Leu 
65                  70                  75                  80  


Leu Gly Arg Gly Ser Met Phe Val Phe Ser Pro Asp Gln Phe Gln Arg 
                85                  90                  95      


Leu Leu Lys Ile Asn Pro Asp Trp Lys Thr His Arg Leu Leu Asp Leu 
            100                 105                 110         


Gly Ala Gly Asp Gly Glu Val Thr Lys Ile Met Ser Pro His Phe Glu 
        115                 120                 125             


Glu Ile Tyr Ala Thr Glu Leu Ser Glu Thr Met Ile Trp Gln Leu Gln 
    130                 135                 140                 


Lys Lys Lys Tyr Arg Val Leu Gly Ile Asn Glu Trp Gln Asn Thr Gly 
145                 150                 155                 160 


Phe Gln Tyr Asp Val Ile Ser Cys Leu Asn Leu Leu Asp Arg Cys Asp 
                165                 170                 175     


Gln Pro Leu Thr Leu Leu Lys Asp Ile Arg Ser Val Leu Glu Pro Thr 
            180                 185                 190         


Arg Gly Arg Val Ile Leu Ala Leu Val Leu Pro Phe His Pro Tyr Val 
        195                 200                 205             


Glu Asn Val Gly Gly Lys Trp Glu Lys Pro Ser Glu Ile Leu Glu Ile 
    210                 215                 220                 


Lys Gly Gln Asn Trp Glu Glu Gln Val Asn Ser Leu Pro Glu Val Phe 
225                 230                 235                 240 


Arg Lys Ala 
            


<210>  8594
<211>  61
<212>  PRT
<213>  Homo Sapiens

<400>  8594

Met Arg Leu Leu Ala Gly Trp Leu Cys Leu Ser Leu Ala Ser Val Trp 
1               5                   10                  15      


Leu Ala Arg Arg Met Trp Thr Leu Arg Ser Pro Leu Thr Arg Ser Leu 
            20                  25                  30          


Gly Met Cys Ala Thr Glu Arg Asn Tyr Ala Asn His Ser Arg Leu Ser 
        35                  40                  45              


Leu Phe Arg Val Thr Leu Ile Lys Glu His Arg Ser Ser 
    50                  55                  60      


<210>  8595
<211>  74
<212>  PRT
<213>  Homo Sapiens

<400>  8595

Met Arg Leu Leu Ala Gly Trp Leu Cys Leu Ser Leu Ala Ser Val Trp 
1               5                   10                  15      


Leu Ala Arg Arg Met Trp Thr Leu Arg Ser Pro Leu Thr Arg Ser Leu 
            20                  25                  30          


Tyr Val Asn Met Thr Ser Gly Pro Gly Gly Pro Ala Ala Ala Ala Gly 
        35                  40                  45              


Gly Arg Lys Glu Asn His Gln Val Ala Arg Lys Arg Leu Asn Val Cys 
    50                  55                  60                  


Val Phe Thr Arg Ser Val Ser Glu Thr Ala 
65                  70                  


<210>  8596
<211>  317
<212>  PRT
<213>  Homo Sapiens

<400>  8596

Met Arg Leu Leu Ala Gly Trp Leu Cys Leu Ser Leu Ala Ser Val Trp 
1               5                   10                  15      


Leu Ala Arg Arg Met Trp Thr Leu Arg Ser Pro Leu Thr Arg Ser Leu 
            20                  25                  30          


Tyr Val Asn Met Thr Ser Gly Pro Gly Gly Pro Ala Ala Ala Ala Gly 
        35                  40                  45              


Gly Arg Lys Glu Asn His Gln Trp Tyr Val Cys Asn Arg Glu Lys Leu 
    50                  55                  60                  


Cys Glu Ser Leu Gln Ala Val Phe Val Gln Ser Tyr Leu Asp Gln Gly 
65                  70                  75                  80  


Thr Gln Ile Phe Leu Asn Asn Ser Ile Glu Lys Ser Gly Trp Leu Phe 
                85                  90                  95      


Ile Gln Leu Tyr His Ser Phe Val Ser Ser Val Phe Ser Leu Phe Met 
            100                 105                 110         


Ser Arg Thr Ser Ile Asn Gly Leu Leu Gly Arg Gly Ser Met Phe Val 
        115                 120                 125             


Phe Ser Pro Asp Gln Phe Gln Arg Leu Leu Lys Ile Asn Pro Asp Trp 
    130                 135                 140                 


Lys Thr His Arg Leu Leu Asp Leu Gly Ala Gly Asp Gly Glu Val Thr 
145                 150                 155                 160 


Lys Ile Met Ser Pro His Phe Glu Glu Ile Tyr Ala Thr Glu Leu Ser 
                165                 170                 175     


Glu Thr Met Ile Trp Gln Leu Gln Lys Lys Lys Tyr Arg Val Leu Gly 
            180                 185                 190         


Ile Asn Glu Trp Gln Asn Thr Gly Phe Gln Tyr Asp Val Ile Ser Cys 
        195                 200                 205             


Leu Asn Leu Leu Asp Arg Cys Asp Gln Pro Leu Thr Leu Leu Lys Asp 
    210                 215                 220                 


Ile Arg Ser Val Leu Glu Pro Thr Arg Gly Arg Val Ile Leu Ala Leu 
225                 230                 235                 240 


Val Leu Pro Phe His Pro Tyr Val Glu Asn Gly Gly Lys Trp Glu Lys 
                245                 250                 255     


Pro Ser Glu Ile Leu Glu Ile Lys Gly Gln Asn Trp Glu Glu Gln Val 
            260                 265                 270         


Asn Ser Leu Pro Glu Val Phe Arg Lys Ala Gly Phe Val Ile Glu Ala 
        275                 280                 285             


Phe Thr Arg Leu Pro Tyr Leu Cys Glu Gly Asp Met Tyr Asn Asp Tyr 
    290                 295                 300                 


Tyr Val Leu Asp Asp Ala Val Phe Val Leu Lys Pro Val 
305                 310                 315         


<210>  8597
<211>  318
<212>  PRT
<213>  Homo Sapiens

<400>  8597

Met Arg Leu Leu Ala Gly Trp Leu Cys Leu Ser Leu Ala Ser Val Trp 
1               5                   10                  15      


Leu Ala Arg Arg Met Trp Thr Leu Arg Ser Pro Leu Thr Arg Ser Leu 
            20                  25                  30          


Tyr Val Asn Met Thr Ser Gly Pro Gly Gly Pro Ala Ala Ala Ala Gly 
        35                  40                  45              


Gly Arg Lys Glu Asn His Gln Trp Tyr Val Cys Asn Arg Glu Lys Leu 
    50                  55                  60                  


Cys Glu Ser Leu Gln Ala Val Phe Val Gln Ser Tyr Leu Asp Gln Gly 
65                  70                  75                  80  


Thr Gln Ile Phe Leu Asn Asn Ser Ile Glu Lys Ser Gly Trp Leu Phe 
                85                  90                  95      


Ile Gln Leu Tyr His Ser Phe Val Ser Ser Val Phe Ser Leu Phe Met 
            100                 105                 110         


Ser Arg Thr Ser Ile Asn Gly Leu Leu Gly Arg Gly Ser Met Phe Val 
        115                 120                 125             


Phe Ser Pro Asp Gln Phe Gln Arg Leu Leu Lys Ile Asn Pro Asp Trp 
    130                 135                 140                 


Lys Thr His Arg Leu Leu Asp Leu Gly Ala Gly Asp Gly Glu Val Thr 
145                 150                 155                 160 


Lys Ile Met Ser Pro His Phe Glu Glu Ile Tyr Ala Thr Glu Leu Ser 
                165                 170                 175     


Glu Thr Met Ile Trp Gln Leu Gln Lys Lys Lys Tyr Arg Val Leu Gly 
            180                 185                 190         


Ile Asn Glu Trp Gln Asn Thr Gly Phe Gln Tyr Asp Val Ile Ser Cys 
        195                 200                 205             


Leu Asn Leu Leu Asp Arg Cys Asp Gln Pro Leu Thr Leu Leu Lys Asp 
    210                 215                 220                 


Ile Arg Ser Val Leu Glu Pro Thr Arg Gly Arg Val Ile Leu Ala Leu 
225                 230                 235                 240 


Val Leu Pro Phe His Pro Tyr Val Glu Asn Val Gly Gly Lys Trp Glu 
                245                 250                 255     


Lys Pro Ser Glu Ile Leu Glu Ile Lys Gly Gln Asn Trp Glu Glu Gln 
            260                 265                 270         


Val Asn Ser Leu Pro Glu Val Phe Arg Lys Ala Gly Phe Val Ile Glu 
        275                 280                 285             


Ala Phe Thr Arg Leu Pro Tyr Leu Cys Glu Gly Asp Met Tyr Asn Asp 
    290                 295                 300                 


Tyr Tyr Val Leu Asp Asp Ala Val Phe Val Leu Lys Pro Val 
305                 310                 315             


<210>  8598
<211>  139
<212>  PRT
<213>  Homo Sapiens

<400>  8598

Met Ser Arg Thr Ser Ile Asn Gly Leu Leu Gly Arg Gly Ser Met Phe 
1               5                   10                  15      


Val Phe Ser Pro Asp Gln Phe Gln Arg Leu Leu Lys Ile Asn Pro Asp 
            20                  25                  30          


Trp Lys Thr His Arg Leu Leu Asp Leu Gly Ala Gly Asp Gly Glu Val 
        35                  40                  45              


Thr Lys Ile Met Ser Pro His Phe Glu Glu Ile Tyr Ala Thr Glu Leu 
    50                  55                  60                  


Ser Glu Thr Met Ile Trp Gln Leu Gln Lys Lys Lys Tyr Arg Val Leu 
65                  70                  75                  80  


Gly Ile Asn Glu Trp Gln Asn Thr Gly Phe Gln Tyr Asp Val Ile Ser 
                85                  90                  95      


Cys Leu Asn Leu Leu Asp Arg Cys Asp Gln Pro Leu Thr Leu Leu Lys 
            100                 105                 110         


Asp Ile Arg Ser Val Leu Glu Pro Thr Arg Gly Arg Val Ile Leu Ala 
        115                 120                 125             


Leu Val Leu Pro Phe His Pro Tyr Val Glu Asn 
    130                 135                 


<210>  8599
<211>  282
<212>  PRT
<213>  Homo Sapiens

<400>  8599

Met Trp Thr Leu Arg Ser Pro Leu Thr Arg Ser Leu Tyr Val Lys Glu 
1               5                   10                  15      


Asn His Gln Trp Tyr Val Cys Asn Arg Glu Lys Leu Cys Glu Ser Leu 
            20                  25                  30          


Gln Ala Val Phe Val Gln Ser Tyr Leu Asp Gln Gly Thr Gln Ile Phe 
        35                  40                  45              


Leu Asn Asn Ser Ile Glu Lys Ser Gly Trp Leu Phe Ile Gln Leu Tyr 
    50                  55                  60                  


His Ser Phe Val Ser Ser Val Phe Ser Leu Phe Met Ser Arg Thr Ser 
65                  70                  75                  80  


Ile Asn Gly Leu Leu Gly Arg Gly Ser Met Phe Val Phe Ser Pro Asp 
                85                  90                  95      


Gln Phe Gln Arg Leu Leu Lys Ile Asn Pro Asp Trp Lys Thr His Arg 
            100                 105                 110         


Leu Leu Asp Leu Gly Ala Gly Asp Gly Glu Val Thr Lys Ile Met Ser 
        115                 120                 125             


Pro His Phe Glu Glu Ile Tyr Ala Thr Glu Leu Ser Glu Thr Met Ile 
    130                 135                 140                 


Trp Gln Leu Gln Lys Lys Lys Tyr Arg Val Leu Gly Ile Asn Glu Trp 
145                 150                 155                 160 


Gln Asn Thr Gly Phe Gln Tyr Asp Val Ile Ser Cys Leu Asn Leu Leu 
                165                 170                 175     


Asp Arg Cys Asp Gln Pro Leu Thr Leu Leu Lys Asp Ile Arg Ser Val 
            180                 185                 190         


Leu Glu Pro Thr Arg Gly Arg Val Ile Leu Ala Leu Val Leu Pro Phe 
        195                 200                 205             


His Pro Tyr Val Glu Asn Val Gly Gly Lys Trp Glu Lys Pro Ser Glu 
    210                 215                 220                 


Ile Leu Glu Ile Lys Gly Gln Asn Trp Glu Glu Gln Val Asn Ser Leu 
225                 230                 235                 240 


Pro Glu Val Phe Arg Lys Ala Gly Phe Val Ile Glu Ala Phe Thr Arg 
                245                 250                 255     


Leu Pro Tyr Leu Cys Glu Gly Asp Met Tyr Asn Asp Tyr Tyr Val Leu 
            260                 265                 270         


Asp Asp Ala Val Phe Val Leu Lys Pro Val 
        275                 280         


<210>  8600
<211>  128
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8600

Xaa Pro Asp Gln Phe Gln Arg Leu Leu Lys Ile Asn Pro Asp Trp Lys 
1               5                   10                  15      


Thr His Arg Leu Leu Asp Leu Gly Ala Gly Asp Gly Glu Val Thr Lys 
            20                  25                  30          


Ile Met Ser Pro His Phe Glu Glu Ile Tyr Ala Thr Glu Leu Ser Glu 
        35                  40                  45              


Thr Met Ile Trp Gln Leu Gln Lys Lys Lys Tyr Arg Val Leu Gly Ile 
    50                  55                  60                  


Asn Glu Trp Gln Asn Thr Gly Phe Gln Tyr Asp Val Ile Ser Cys Leu 
65                  70                  75                  80  


Asn Leu Leu Asp Arg Cys Asp Gln Pro Leu Thr Leu Leu Lys Asp Ile 
                85                  90                  95      


Arg Ser Val Leu Glu Pro Thr Arg Gly Arg Val Ile Leu Ala Leu Val 
            100                 105                 110         


Leu Pro Phe His Pro Tyr Val Glu Asn Gly Lys Cys Gly Gln Ser Gly 
        115                 120                 125             


<210>  8601
<211>  125
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8601

Xaa Ser Tyr Leu Asp Gln Gly Thr Gln Ile Phe Leu Asn Asn Ser Ile 
1               5                   10                  15      


Glu Lys Ser Gly Trp Leu Phe Ile Gln Leu Tyr His Ser Phe Val Ser 
            20                  25                  30          


Ser Val Phe Ser Leu Phe Met Ser Arg Thr Ser Ile Asn Gly Val Leu 
        35                  40                  45              


Gly Ile Asn Glu Trp Gln Asn Thr Gly Phe Gln Tyr Asp Val Ile Ser 
    50                  55                  60                  


Cys Leu Asn Leu Leu Asp Arg Cys Asp Gln Pro Leu Thr Leu Leu Lys 
65                  70                  75                  80  


Asp Ile Arg Ser Val Leu Glu Pro Thr Arg Gly Arg Val Ile Leu Ala 
                85                  90                  95      


Leu Val Leu Pro Phe His Pro Tyr Val Glu Asn Val Gly Gly Lys Trp 
            100                 105                 110         


Glu Lys Pro Ser Glu Ile Leu Glu Ile Lys Gly Gln Asn 
        115                 120                 125 


<210>  8602
<211>  489
<212>  PRT
<213>  Homo Sapiens

<400>  8602

Met Pro Ser Gly Ser Ser Ala Ala Leu Ala Leu Ala Ala Ala Gly Val 
1               5                   10                  15      


Leu Tyr Gly Gly Asp Asp Ala Gln Gly Met Met Ala Ala Met Leu Ser 
            20                  25                  30          


His Ala Tyr Gly Pro Gly Gly Cys Gly Ala Ala Ala Ala Ala Leu Asn 
        35                  40                  45              


Gly Glu Gln Ala Ala Leu Leu Arg Arg Lys Ser Val Asn Thr Thr Glu 
    50                  55                  60                  


Cys Val Pro Val Pro Ser Ser Glu His Val Ala Glu Ile Val Gly Arg 
65                  70                  75                  80  


Gln Gly Cys Lys Ile Lys Ala Leu Arg Ala Lys Thr Asn Thr Tyr Ile 
                85                  90                  95      


Lys Thr Pro Val Arg Gly Glu Glu Pro Ile Phe Val Val Thr Gly Arg 
            100                 105                 110         


Lys Glu Asp Val Ala Met Ala Lys Arg Glu Ile Leu Ser Ala Ala Glu 
        115                 120                 125             


His Phe Ser Met Ile Arg Ala Ser Arg Asn Lys Asn Gly Pro Ala Leu 
    130                 135                 140                 


Gly Gly Leu Ser Cys Ser Pro Asn Leu Pro Gly Gln Thr Thr Val Gln 
145                 150                 155                 160 


Val Arg Val Pro Tyr Arg Val Val Gly Leu Val Val Gly Pro Lys Gly 
                165                 170                 175     


Ala Thr Ile Lys Arg Ile Gln Gln Gln Thr His Thr Tyr Ile Val Thr 
            180                 185                 190         


Pro Ser Arg Asp Lys Glu Pro Val Phe Glu Val Thr Gly Met Pro Glu 
        195                 200                 205             


Asn Val Asp Arg Ala Arg Glu Glu Ile Glu Met His Ile Ala Met Arg 
    210                 215                 220                 


Thr Gly Asn Tyr Ile Glu Leu Asn Glu Glu Asn Asp Phe His Tyr Asn 
225                 230                 235                 240 


Gly Thr Asp Val Ser Phe Glu Gly Gly Thr Leu Gly Ser Ala Trp Leu 
                245                 250                 255     


Ser Ser Asn Pro Val Pro Pro Ser Arg Ala Arg Met Ile Ser Asn Tyr 
            260                 265                 270         


Arg Asn Asp Ser Ser Ser Ser Leu Gly Ser Gly Ser Thr Asp Ser Tyr 
        275                 280                 285             


Phe Gly Ser Asn Arg Leu Ala Asp Phe Ser Pro Thr Ser Pro Phe Ser 
    290                 295                 300                 


Thr Gly Asn Phe Trp Phe Gly Asp Thr Leu Pro Ser Val Gly Ser Glu 
305                 310                 315                 320 


Asp Leu Ala Val Asp Ser Pro Ala Phe Asp Ser Leu Pro Thr Ser Ala 
                325                 330                 335     


Gln Thr Ile Trp Thr Pro Phe Glu Pro Val Asn Pro Leu Ser Gly Phe 
            340                 345                 350         


Gly Ser Asp Pro Ser Gly Asn Met Lys Thr Gln Arg Arg Gly Ser Gln 
        355                 360                 365             


Pro Ser Thr Pro Arg Leu Ser Pro Thr Phe Pro Glu Ser Ile Glu His 
    370                 375                 380                 


Pro Leu Ala Arg Arg Val Arg Ser Asp Pro Pro Ser Thr Gly Asn His 
385                 390                 395                 400 


Val Gly Leu Pro Ile Tyr Ile Pro Ala Phe Ser Asn Gly Thr Asn Ser 
                405                 410                 415     


Tyr Ser Ser Ser Asn Gly Gly Ser Thr Ser Ser Ser Pro Pro Glu Ser 
            420                 425                 430         


Arg Arg Lys His Asp Cys Val Ile Cys Phe Glu Asn Glu Val Ile Ala 
        435                 440                 445             


Ala Leu Val Pro Cys Gly His Asn Leu Phe Cys Met Glu Cys Ala Asn 
    450                 455                 460                 


Lys Ile Cys Glu Lys Arg Thr Pro Ser Cys Pro Val Cys Gln Thr Ala 
465                 470                 475                 480 


Val Thr Gln Ala Ile Gln Ile His Ser 
                485                 


<210>  8603
<211>  659
<212>  PRT
<213>  Homo Sapiens

<400>  8603

Met Pro Ser Gly Ser Ser Ala Ala Leu Ala Leu Ala Ala Ala Pro Ala 
1               5                   10                  15      


Pro Leu Pro Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Leu 
            20                  25                  30          


Pro Pro Pro Ser Gly Gly Pro Glu Leu Glu Gly Asp Gly Leu Leu Leu 
        35                  40                  45              


Arg Glu Arg Leu Ala Ala Leu Gly Leu Asp Asp Pro Ser Pro Ala Glu 
    50                  55                  60                  


Pro Gly Ala Pro Ala Leu Arg Ala Pro Ala Ala Ala Ala Gln Gly Gln 
65                  70                  75                  80  


Ala Arg Arg Ala Ala Glu Leu Ser Pro Glu Glu Arg Ala Pro Pro Gly 
                85                  90                  95      


Arg Pro Gly Ala Pro Glu Ala Ala Glu Leu Glu Leu Glu Glu Asp Glu 
            100                 105                 110         


Glu Glu Gly Glu Glu Ala Glu Leu Asp Gly Asp Leu Leu Glu Glu Glu 
        115                 120                 125             


Glu Leu Glu Glu Ala Glu Glu Glu Asp Arg Ser Ser Leu Leu Leu Leu 
    130                 135                 140                 


Ser Pro Pro Ala Ala Thr Ala Ser Gln Thr Gln Gln Ile Pro Gly Gly 
145                 150                 155                 160 


Ser Leu Gly Ser Val Leu Leu Pro Ala Ala Arg Phe Asp Ala Arg Glu 
                165                 170                 175     


Ala Ala Ala Ala Ala Ala Ala Ala Gly Val Leu Tyr Gly Gly Asp Asp 
            180                 185                 190         


Ala Gln Gly Met Met Ala Ala Met Leu Ser His Ala Tyr Gly Pro Gly 
        195                 200                 205             


Gly Cys Gly Ala Ala Ala Ala Ala Leu Asn Gly Glu Gln Ala Ala Leu 
    210                 215                 220                 


Leu Arg Arg Lys Ser Val Asn Thr Thr Glu Cys Val Pro Val Pro Ser 
225                 230                 235                 240 


Ser Glu His Val Ala Glu Ile Val Gly Arg Gln Gly Cys Lys Ile Lys 
                245                 250                 255     


Ala Leu Arg Ala Lys Thr Asn Thr Tyr Ile Lys Thr Pro Val Arg Gly 
            260                 265                 270         


Glu Glu Pro Ile Phe Val Val Thr Gly Arg Lys Glu Asp Val Ala Met 
        275                 280                 285             


Ala Lys Arg Glu Ile Leu Ser Ala Ala Glu His Phe Ser Met Ile Arg 
    290                 295                 300                 


Ala Ser Arg Asn Lys Asn Gly Pro Ala Leu Gly Gly Leu Ser Cys Ser 
305                 310                 315                 320 


Pro Asn Leu Pro Gly Gln Thr Thr Val Gln Val Arg Val Pro Tyr Arg 
                325                 330                 335     


Val Val Gly Leu Val Val Gly Pro Lys Gly Ala Thr Ile Lys Arg Ile 
            340                 345                 350         


Gln Gln Gln Thr His Thr Tyr Ile Val Thr Pro Ser Arg Asp Lys Glu 
        355                 360                 365             


Pro Val Phe Glu Val Thr Gly Met Pro Glu Asn Val Asp Arg Ala Arg 
    370                 375                 380                 


Glu Glu Ile Glu Met His Ile Ala Met Arg Thr Gly Asn Tyr Ile Glu 
385                 390                 395                 400 


Leu Asn Glu Glu Asn Asp Phe His Tyr Asn Gly Thr Asp Val Ser Phe 
                405                 410                 415     


Glu Gly Gly Thr Leu Gly Ser Ala Trp Leu Ser Ser Asn Pro Val Pro 
            420                 425                 430         


Pro Ser Arg Ala Arg Met Ile Ser Asn Tyr Arg Asn Asp Ser Ser Ser 
        435                 440                 445             


Ser Leu Gly Ser Gly Ser Thr Asp Ser Tyr Phe Gly Ser Asn Arg Leu 
    450                 455                 460                 


Ala Asp Phe Ser Pro Thr Ser Pro Phe Ser Thr Gly Asn Phe Trp Phe 
465                 470                 475                 480 


Gly Asp Thr Leu Pro Ser Val Gly Ser Glu Asp Leu Ala Val Asp Ser 
                485                 490                 495     


Pro Ala Phe Asp Ser Leu Pro Thr Ser Ala Gln Thr Ile Trp Thr Pro 
            500                 505                 510         


Phe Glu Pro Val Asn Pro Leu Ser Gly Phe Gly Ser Asp Pro Ser Gly 
        515                 520                 525             


Asn Met Lys Thr Gln Arg Arg Gly Ser Gln Pro Ser Thr Pro Arg Leu 
    530                 535                 540                 


Ser Pro Thr Phe Pro Glu Ser Ile Glu His Pro Leu Ala Arg Arg Val 
545                 550                 555                 560 


Arg Ser Asp Pro Pro Ser Thr Gly Asn His Val Gly Leu Pro Ile Tyr 
                565                 570                 575     


Ile Pro Ala Phe Ser Asn Gly Thr Asn Ser Tyr Ser Ser Ser Asn Gly 
            580                 585                 590         


Gly Ser Thr Ser Ser Ser Pro Pro Glu Ser Arg Arg Lys His Asp Cys 
        595                 600                 605             


Val Ile Cys Phe Glu Asn Glu Val Ile Ala Ala Leu Val Pro Cys Gly 
    610                 615                 620                 


His Asn Leu Phe Cys Met Glu Cys Ala Asn Lys Ile Cys Glu Lys Arg 
625                 630                 635                 640 


Thr Pro Ser Cys Pro Val Cys Gln Thr Ala Val Thr Gln Ala Ile Gln 
                645                 650                 655     


Ile His Ser 
            


<210>  8604
<211>  115
<212>  PRT
<213>  Homo Sapiens

<400>  8604

Tyr Gly Gly Asp Asp Ala Gln Gly Met Met Ala Ala Met Leu Ser His 
1               5                   10                  15      


Ala Tyr Gly Pro Gly Gly Cys Gly Ala Ala Ala Ala Ala Leu Asn Gly 
            20                  25                  30          


Glu Gln Ala Ala Leu Leu Arg Arg Lys Ser Val Asn Thr Thr Glu Cys 
        35                  40                  45              


Val Pro Val Pro Ser Ser Glu His Val Ala Glu Ile Val Gly Arg Gln 
    50                  55                  60                  


Gly Glu Cys Arg Gly Gly Glu Val Gln Leu Gly Met Ala Pro Gly Val 
65                  70                  75                  80  


Gly Gly Glu Thr Arg Glu Arg Ser Val Gly Arg Lys Arg Arg Thr Arg 
                85                  90                  95      


Arg Gly Pro Gln Val His Arg Glu Gly Val Trp Glu Glu Pro Arg Val 
            100                 105                 110         


Asp Gln Met 
        115 


<210>  8605
<211>  183
<212>  PRT
<213>  Homo Sapiens

<400>  8605

Met Arg Ala Ala Tyr Leu Phe Leu Leu Phe Leu Pro Ala Gly Leu Leu 
1               5                   10                  15      


Ala Gln Gly Gln Tyr Asp Leu Asp Pro Leu Pro Pro Phe Pro Asp His 
            20                  25                  30          


Val Gln Tyr Thr His Tyr Ser Asp Gln Ile Asp Asn Pro Asp Tyr Tyr 
        35                  40                  45              


Asp Tyr Gln Glu Val Thr Pro Arg Pro Ser Glu Glu Gln Phe Gln Phe 
    50                  55                  60                  


Gln Ser Gln Gln Gln Val Gln Gln Glu Val Ile Pro Ala Pro Thr Pro 
65                  70                  75                  80  


Glu Pro Gly Asn Ala Glu Leu Glu Pro Thr Glu Pro Gly Pro Leu Asp 
                85                  90                  95      


Cys Arg Glu Glu Gln Tyr Pro Cys Thr Arg Leu Tyr Ser Ile His Arg 
            100                 105                 110         


Pro Cys Lys Gln Cys Leu Asn Glu Val Cys Phe Tyr Ser Leu Arg Arg 
        115                 120                 125             


Val Tyr Val Ile Asn Lys Glu Ile Cys Val Arg Thr Val Cys Ala His 
    130                 135                 140                 


Glu Glu Leu Leu Arg Ala Asp Leu Cys Arg Asp Lys Phe Ser Lys Cys 
145                 150                 155                 160 


Gly Val Met Ala Ser Ser Gly Leu Cys Gln Ser Val Ala Ala Ser Cys 
                165                 170                 175     


Ala Arg Ser Cys Gly Ser Cys 
            180             


<210>  8606
<211>  182
<212>  PRT
<213>  Homo Sapiens

<400>  8606

Met Arg Ala Ala Tyr Leu Phe Leu Leu Phe Leu Pro Gly Leu Leu Ala 
1               5                   10                  15      


Gln Gly Gln Tyr Asp Leu Asp Pro Leu Pro Pro Phe Pro Asp His Val 
            20                  25                  30          


Gln Tyr Thr His Tyr Ser Asp Gln Ile Asp Asn Pro Asp Tyr Tyr Asp 
        35                  40                  45              


Tyr Gln Glu Val Thr Pro Arg Pro Ser Glu Glu Gln Phe Gln Phe Gln 
    50                  55                  60                  


Ser Gln Gln Gln Val Gln Gln Glu Val Ile Pro Ala Pro Thr Pro Glu 
65                  70                  75                  80  


Pro Gly Asn Ala Glu Leu Glu Pro Thr Glu Pro Gly Pro Leu Asp Cys 
                85                  90                  95      


Arg Glu Glu Gln Tyr Pro Cys Thr Arg Leu Tyr Ser Ile His Arg Pro 
            100                 105                 110         


Cys Lys Gln Cys Leu Asn Glu Val Cys Phe Tyr Ser Leu Arg Arg Val 
        115                 120                 125             


Tyr Val Ile Asn Lys Glu Ile Cys Val Arg Thr Val Cys Ala His Glu 
    130                 135                 140                 


Glu Leu Leu Arg Ala Asp Leu Cys Arg Asp Lys Phe Ser Lys Cys Gly 
145                 150                 155                 160 


Val Met Ala Ser Ser Gly Leu Cys Gln Ser Val Ala Ala Ser Cys Ala 
                165                 170                 175     


Arg Ser Cys Gly Ser Cys 
            180         


<210>  8607
<211>  17
<212>  PRT
<213>  Homo Sapiens

<400>  8607

Met Lys Leu His Cys Cys Leu Phe Thr Leu Val Ala Ser Ile Ile Val 
1               5                   10                  15      


Pro 
    


<210>  8608
<211>  109
<212>  PRT
<213>  Homo Sapiens

<400>  8608

Met Lys Leu His Cys Cys Leu Phe Thr Leu Val Ala Ser Ile Ile Val 
1               5                   10                  15      


Pro Ala Ala Phe Val Leu Glu Asp Val Asp Phe Asp Gln Met Val Ser 
            20                  25                  30          


Leu Glu Ala Asn Arg Ser Ser Tyr Asn Ala Ser Phe Pro Ser Ser Phe 
        35                  40                  45              


Glu Leu Ser Ala Ser Ser His Ser Asp Asp Asp Val Ile Ile Ala Lys 
    50                  55                  60                  


Glu Gly Thr Ser Val Ser Ile Glu Cys Leu Leu Thr Ala Ser His Tyr 
65                  70                  75                  80  


Glu Asp Val His Trp His Asn Ser Lys Gly Gln Gln Leu Asp Gly Arg 
                85                  90                  95      


Ser Arg Gly Gly Lys Trp Leu Val Ser Asp Asn Phe Leu 
            100                 105                 


<210>  8609
<211>  123
<212>  PRT
<213>  Homo Sapiens

<400>  8609

Met Lys Leu His Cys Cys Leu Phe Thr Leu Val Ala Ser Ile Ile Val 
1               5                   10                  15      


Pro Ala Ala Phe Val Leu Glu Asp Val Asp Phe Asp Gln Met Val Ser 
            20                  25                  30          


Leu Glu Ala Asn Arg Ser Ser Tyr Asn Ala Ser Phe Pro Ser Ser Phe 
        35                  40                  45              


Glu Leu Ser Ala Ser Ser His Ser Asp Asp Asp Val Ile Ile Ala Lys 
    50                  55                  60                  


Glu Gly Thr Ser Val Ser Ile Glu Cys Leu Leu Thr Ala Ser His Tyr 
65                  70                  75                  80  


Glu Asp Val His Trp His Asn Ser Lys Gly Gln Gln Leu Asp Gly Arg 
                85                  90                  95      


Ser Arg Gly Gly Lys Trp Leu Val Ser Asp Asn Phe Leu Asn Ile Thr 
            100                 105                 110         


Asn Val Ala Phe Asp Asp Arg Gly Leu Tyr Thr 
        115                 120             


<210>  8610
<211>  362
<212>  PRT
<213>  Homo Sapiens

<400>  8610

Met Lys Leu His Cys Cys Leu Phe Thr Leu Val Ala Ser Ile Ile Val 
1               5                   10                  15      


Pro Ala Ala Phe Val Leu Glu Asp Val Asp Phe Asp Gln Met Val Ser 
            20                  25                  30          


Leu Glu Ala Asn Arg Ser Ser Tyr Asn Ala Ser Phe Pro Ser Ser Phe 
        35                  40                  45              


Glu Leu Ser Ala Ser Ser His Ser Asp Asp Asp Val Ile Ile Ala Lys 
    50                  55                  60                  


Glu Gly Thr Ser Val Ser Ile Glu Cys Leu Leu Thr Ala Ser His Tyr 
65                  70                  75                  80  


Glu Asp Val His Trp His Asn Ser Lys Gly Gln Gln Leu Asp Gly Arg 
                85                  90                  95      


Ser Arg Gly Gly Lys Trp Leu Val Ser Asp Asn Phe Leu Asn Ile Thr 
            100                 105                 110         


Asn Val Ala Phe Asp Asp Arg Gly Leu Tyr Thr Cys Phe Val Thr Ser 
        115                 120                 125             


Pro Ile Arg Ala Ser Tyr Ser Val Thr Leu Arg Val Ile Phe Thr Ser 
    130                 135                 140                 


Gly Asp Met Ser Val Tyr Tyr Met Ile Val Cys Leu Ile Ala Phe Thr 
145                 150                 155                 160 


Ile Thr Leu Ile Leu Asn Val Thr Arg Leu Cys Met Met Ser Ser His 
                165                 170                 175     


Leu Arg Lys Thr Glu Lys Ala Ile Asn Glu Phe Phe Arg Thr Glu Gly 
            180                 185                 190         


Ala Glu Lys Leu Gln Lys Ala Phe Glu Ile Ala Lys Arg Ile Pro Ile 
        195                 200                 205             


Ile Thr Ser Ala Lys Thr Leu Glu Leu Ala Lys Val Thr Gln Phe Lys 
    210                 215                 220                 


Thr Met Glu Phe Ala Arg Tyr Ile Glu Glu Leu Ala Arg Ser Val Pro 
225                 230                 235                 240 


Leu Pro Pro Leu Ile Leu Asn Cys Arg Ala Phe Val Glu Glu Met Phe 
                245                 250                 255     


Glu Ala Val Arg Val Asp Asp Pro Asp Asp Leu Gly Glu Arg Ile Lys 
            260                 265                 270         


Glu Arg Pro Ala Leu Asn Ala Gln Gly Gly Ile Tyr Val Ile Asn Pro 
        275                 280                 285             


Glu Met Gly Arg Ser Asn Ser Pro Gly Gly Asp Ser Asp Asp Gly Ser 
    290                 295                 300                 


Leu Asn Glu Gln Gly Gln Glu Ile Ala Val Gln Val Ser Val His Leu 
305                 310                 315                 320 


Gln Ser Glu Thr Lys Ser Ile Asp Thr Glu Ser Gln Gly Ser Ser His 
                325                 330                 335     


Phe Ser Pro Pro Asp Asp Ile Gly Ser Ala Glu Ser Asn Cys Asn Tyr 
            340                 345                 350         


Lys Asp Gly Ala Tyr Glu Asn Cys Gln Leu 
        355                 360         


<210>  8611
<211>  216
<212>  PRT
<213>  Homo Sapiens

<400>  8611

Met Ser Val Tyr Tyr Met Ile Val Cys Leu Ile Ala Phe Thr Ile Thr 
1               5                   10                  15      


Leu Ile Leu Asn Val Thr Arg Leu Cys Met Met Ser Ser His Leu Arg 
            20                  25                  30          


Lys Thr Glu Lys Ala Ile Asn Glu Phe Phe Arg Thr Glu Gly Ala Glu 
        35                  40                  45              


Lys Leu Gln Lys Ala Phe Glu Ile Ala Lys Arg Ile Pro Ile Ile Thr 
    50                  55                  60                  


Ser Ala Lys Thr Leu Glu Leu Ala Lys Val Thr Gln Phe Lys Thr Met 
65                  70                  75                  80  


Glu Phe Ala Arg Tyr Ile Glu Glu Leu Ala Arg Ser Val Pro Leu Pro 
                85                  90                  95      


Pro Leu Ile Leu Asn Cys Arg Ala Phe Val Glu Glu Met Phe Glu Ala 
            100                 105                 110         


Val Arg Val Asp Asp Pro Asp Asp Leu Gly Glu Arg Ile Lys Glu Arg 
        115                 120                 125             


Pro Ala Leu Asn Ala Gln Gly Gly Ile Tyr Val Ile Asn Pro Glu Met 
    130                 135                 140                 


Gly Arg Ser Asn Ser Pro Gly Gly Asp Ser Asp Asp Gly Ser Leu Asn 
145                 150                 155                 160 


Glu Gln Gly Gln Glu Ile Ala Val Gln Val Ser Val His Leu Gln Ser 
                165                 170                 175     


Glu Thr Lys Ser Ile Asp Thr Glu Ser Gln Gly Ser Ser His Phe Ser 
            180                 185                 190         


Pro Pro Asp Asp Ile Gly Ser Ala Glu Ser Asn Cys Asn Tyr Lys Asp 
        195                 200                 205             


Gly Ala Tyr Glu Asn Cys Gln Leu 
    210                 215     


<210>  8612
<211>  73
<212>  PRT
<213>  Homo Sapiens

<400>  8612

Met Asp Arg Leu Lys Ser His Leu Thr Val Cys Phe Leu Pro Ser Val 
1               5                   10                  15      


Pro Phe Leu Ile Leu Val Ser Thr Leu Ala Thr Ala Lys Ser Val Thr 
            20                  25                  30          


Asn Ser Thr Leu Asn Gly Thr Asn Val Val Leu Gly Ser Val Pro Val 
        35                  40                  45              


Ile Ile Ala Arg Thr Asp His Ile Ile Val Lys Glu Gly Asn Ser Ala 
    50                  55                  60                  


Leu Ile Asn Cys Ser Val Tyr Gly Ile 
65                  70              


<210>  8613
<211>  90
<212>  PRT
<213>  Homo Sapiens

<400>  8613

Met Asp Arg Leu Lys Ser His Leu Thr Val Cys Phe Leu Pro Ser Val 
1               5                   10                  15      


Pro Phe Leu Ile Leu Val Ser Thr Leu Ala Thr Ala Lys Ser Val Thr 
            20                  25                  30          


Asn Ser Thr Leu Asn Gly Thr Asn Val Val Leu Gly Ser Val Pro Val 
        35                  40                  45              


Ile Ile Ala Arg Thr Asp His Ile Ile Val Lys Glu Gly Asn Ser Ala 
    50                  55                  60                  


Leu Ile Asn Cys Ser Val Tyr Gly Ile Pro Asp Pro Gln Phe Lys Trp 
65                  70                  75                  80  


Tyr Asn Ser Ile Gly Lys Leu Leu Lys Glu 
                85                  90  


<210>  8614
<211>  98
<212>  PRT
<213>  Homo Sapiens

<400>  8614

Met Asp Arg Leu Lys Ser His Leu Thr Val Cys Phe Leu Pro Ser Val 
1               5                   10                  15      


Pro Phe Leu Ile Leu Val Ser Thr Leu Ala Thr Ala Lys Ser Val Thr 
            20                  25                  30          


Asn Ser Thr Leu Asn Gly Thr Asn Val Val Leu Gly Ser Val Pro Val 
        35                  40                  45              


Ile Ile Ala Arg Thr Asp His Ile Ile Val Lys Glu Gly Asn Ser Ala 
    50                  55                  60                  


Leu Ile Asn Cys Ser Val Tyr Gly Ile Pro Asp Pro Gln Phe Lys Trp 
65                  70                  75                  80  


Tyr Asn Ser Ile Gly Lys Leu Leu Lys Glu Glu Glu Asp Glu Lys Glu 
                85                  90                  95      


Arg Gly 
        


<210>  8615
<211>  409
<212>  PRT
<213>  Homo Sapiens

<400>  8615

Met Asp Arg Leu Lys Ser His Leu Thr Val Cys Phe Leu Pro Ser Val 
1               5                   10                  15      


Pro Phe Leu Ile Leu Val Ser Thr Leu Ala Thr Ala Lys Ser Val Thr 
            20                  25                  30          


Asn Ser Thr Leu Asn Gly Thr Asn Val Val Leu Gly Ser Val Pro Val 
        35                  40                  45              


Ile Ile Ala Arg Thr Asp His Ile Ile Val Lys Glu Gly Asn Ser Ala 
    50                  55                  60                  


Leu Ile Asn Cys Ser Val Tyr Gly Ile Pro Asp Pro Gln Phe Lys Trp 
65                  70                  75                  80  


Tyr Asn Ser Ile Gly Lys Leu Leu Lys Glu Glu Glu Asp Glu Lys Glu 
                85                  90                  95      


Arg Gly Gly Gly Lys Trp Gln Met His Asp Ser Gly Leu Leu Asn Ile 
            100                 105                 110         


Thr Lys Val Ser Phe Ser Asp Arg Gly Lys Tyr Thr Cys Val Ala Ser 
        115                 120                 125             


Asn Ile Tyr Gly Thr Val Asn Asn Thr Val Thr Leu Arg Val Ile Phe 
    130                 135                 140                 


Thr Ser Gly Asp Met Gly Val Tyr Tyr Met Val Val Cys Leu Val Ala 
145                 150                 155                 160 


Phe Thr Ile Val Met Val Leu Asn Ile Thr Arg Leu Cys Met Met Ser 
                165                 170                 175     


Ser His Leu Lys Lys Thr Glu Lys Ala Ile Asn Glu Phe Phe Arg Thr 
            180                 185                 190         


Glu Gly Ala Glu Lys Leu Gln Lys Ala Phe Glu Ile Ala Lys Arg Ile 
        195                 200                 205             


Pro Ile Ile Thr Ser Ala Lys Thr Leu Glu Leu Ala Lys Val Thr Gln 
    210                 215                 220                 


Phe Lys Thr Met Glu Phe Ala Arg Tyr Ile Glu Glu Leu Ala Arg Ser 
225                 230                 235                 240 


Val Pro Leu Pro Pro Leu Ile Met Asn Cys Arg Thr Ile Met Glu Glu 
                245                 250                 255     


Ile Met Glu Val Val Gly Leu Glu Glu Gln Gly Gln Asn Phe Val Arg 
            260                 265                 270         


His Thr Pro Glu Gly Gln Glu Ala Ala Asp Arg Asp Glu Val Tyr Thr 
        275                 280                 285             


Ile Pro Asn Ser Leu Lys Arg Ser Asp Ser Pro Ala Ala Asp Ser Asp 
    290                 295                 300                 


Ala Ser Ser Leu His Glu Gln Pro Gln Gln Ile Ala Ile Lys Val Ser 
305                 310                 315                 320 


Val His Pro Gln Ser Lys Lys Glu His Ala Asp Asp Gln Glu Gly Gly 
                325                 330                 335     


Gln Phe Glu Val Lys Asp Val Glu Glu Thr Glu Leu Ser Ala Glu His 
            340                 345                 350         


Ser Pro Glu Thr Ala Glu Pro Ser Thr Asp Val Thr Ser Thr Glu Leu 
        355                 360                 365             


Thr Ser Glu Glu Pro Thr Pro Val Glu Val Pro Asp Lys Val Leu Pro 
    370                 375                 380                 


Pro Ala Tyr Leu Glu Ala Thr Glu Pro Ala Val Thr His Asp Lys Asn 
385                 390                 395                 400 


Thr Cys Ile Ile Tyr Glu Ser His Val 
                405                 


<210>  8616
<211>  102
<212>  PRT
<213>  Homo Sapiens

<400>  8616

Met Asp Arg Leu Lys Ser His Leu Thr Val Cys Phe Leu Pro Ser Val 
1               5                   10                  15      


Pro Phe Leu Ile Leu Val Ser Thr Leu Ala Thr Ala Lys Ser Val Thr 
            20                  25                  30          


Asn Ser Thr Leu Asn Gly Thr Asn Val Val Leu Gly Ser Val Pro Val 
        35                  40                  45              


Ile Ile Ala Arg Thr Asp His Ile Ile Val Lys Glu Gly Asn Ser Ala 
    50                  55                  60                  


Leu Ile Asn Cys Ser Val Tyr Gly Ile Pro Asp Pro Gln Phe Lys Trp 
65                  70                  75                  80  


Tyr Asn Ser Ile Gly Lys Leu Leu Lys Glu Glu Glu Asp Glu Lys Glu 
                85                  90                  95      


Arg Gly Gly Gly Arg Leu 
            100         


<210>  8617
<211>  102
<212>  PRT
<213>  Homo Sapiens

<400>  8617

Met Asp Arg Leu Lys Ser His Leu Thr Val Cys Phe Leu Pro Ser Val 
1               5                   10                  15      


Pro Phe Leu Ile Leu Val Ser Thr Leu Ala Thr Ala Lys Ser Val Thr 
            20                  25                  30          


Asn Ser Thr Leu Asn Gly Thr Asn Val Val Leu Gly Ser Val Pro Val 
        35                  40                  45              


Ile Ile Ala Arg Thr Asp His Ile Ile Val Lys Glu Gly Asn Ser Ala 
    50                  55                  60                  


Leu Ile Asn Cys Ser Val Tyr Gly Ile Pro Asp Pro Gln Phe Lys Trp 
65                  70                  75                  80  


Tyr Asn Ser Ile Gly Lys Leu Leu Lys Glu Glu Glu Asp Glu Lys Glu 
                85                  90                  95      


Arg Gly Gly Gly Arg Leu 
            100         


<210>  8618
<211>  44
<212>  PRT
<213>  Homo Sapiens

<400>  8618

Met His Asp Ser Gly Leu Leu Asn Ile Thr Lys Val Ser Phe Ser Asp 
1               5                   10                  15      


Arg Gly Lys Tyr Thr Cys Val Ala Ser Asn Ile Tyr Gly Thr Val Asn 
            20                  25                  30          


Asn Thr Val Thr Leu Arg Val Ile Phe Thr Ser Gly 
        35                  40                  


<210>  8619
<211>  64
<212>  PRT
<213>  Homo Sapiens

<400>  8619

Met His Asp Ser Gly Leu Leu Asn Ile Thr Lys Val Ser Phe Ser Asp 
1               5                   10                  15      


Arg Gly Lys Tyr Thr Cys Val Ala Ser Asn Ile Tyr Gly Thr Val Asn 
            20                  25                  30          


Asn Thr Val Thr Leu Arg Val Ile Phe Thr Ser Gly Asp Met Gly Val 
        35                  40                  45              


Tyr Tyr Met Val Val Cys Leu Val Ala Phe Thr Ile Val Met Val Leu 
    50                  55                  60                  


<210>  8620
<211>  157
<212>  PRT
<213>  Homo Sapiens

<400>  8620

Met His Asp Ser Gly Leu Leu Asn Ile Thr Lys Val Ser Phe Ser Asp 
1               5                   10                  15      


Arg Gly Lys Tyr Thr Cys Val Ala Ser Asn Ile Tyr Gly Thr Val Asn 
            20                  25                  30          


Asn Thr Val Thr Leu Arg Val Ile Phe Thr Ser Gly Asp Met Gly Val 
        35                  40                  45              


Tyr Tyr Met Val Val Cys Leu Val Ala Phe Thr Ile Val Met Val Leu 
    50                  55                  60                  


Asn Ile Thr Arg Leu Cys Met Met Ser Ser His Leu Lys Lys Thr Glu 
65                  70                  75                  80  


Lys Ala Ile Asn Glu Phe Phe Arg Thr Glu Gly Ala Glu Lys Leu Gln 
                85                  90                  95      


Lys Ala Phe Glu Ile Ala Lys Arg Ile Pro Ile Ile Thr Ser Ala Lys 
            100                 105                 110         


Thr Leu Glu Leu Ala Lys Val Thr Gln Phe Lys Thr Met Glu Phe Ala 
        115                 120                 125             


Arg Tyr Ile Glu Glu Leu Ala Arg Ser Val Pro Leu Pro Pro Leu Ile 
    130                 135                 140                 


Met Asn Cys Arg Thr Ile Met Glu Glu Ile Met Glu Val 
145                 150                 155         


<210>  8621
<211>  306
<212>  PRT
<213>  Homo Sapiens

<400>  8621

Met His Asp Ser Gly Leu Leu Asn Ile Thr Lys Val Ser Phe Ser Asp 
1               5                   10                  15      


Arg Gly Lys Tyr Thr Cys Val Ala Ser Asn Ile Tyr Gly Thr Val Asn 
            20                  25                  30          


Asn Thr Val Thr Leu Arg Val Ile Phe Thr Ser Gly Asp Met Gly Val 
        35                  40                  45              


Tyr Tyr Met Val Val Cys Leu Val Ala Phe Thr Ile Val Met Val Leu 
    50                  55                  60                  


Asn Ile Thr Arg Leu Cys Met Met Ser Ser His Leu Lys Lys Thr Glu 
65                  70                  75                  80  


Lys Ala Ile Asn Glu Phe Phe Arg Thr Glu Gly Ala Glu Lys Leu Gln 
                85                  90                  95      


Lys Ala Phe Glu Ile Ala Lys Arg Ile Pro Ile Ile Thr Ser Ala Lys 
            100                 105                 110         


Thr Leu Glu Leu Ala Lys Val Thr Gln Phe Lys Thr Met Glu Phe Ala 
        115                 120                 125             


Arg Tyr Ile Glu Glu Leu Ala Arg Ser Val Pro Leu Pro Pro Leu Ile 
    130                 135                 140                 


Met Asn Cys Arg Thr Ile Met Glu Glu Ile Met Glu Val Val Gly Leu 
145                 150                 155                 160 


Glu Glu Gln Gly Gln Asn Phe Val Arg His Thr Pro Glu Gly Gln Glu 
                165                 170                 175     


Ala Ala Asp Arg Asp Glu Val Tyr Thr Ile Pro Asn Ser Leu Lys Arg 
            180                 185                 190         


Ser Asp Ser Pro Ala Ala Asp Ser Asp Ala Ser Ser Leu His Glu Gln 
        195                 200                 205             


Pro Gln Gln Ile Ala Ile Lys Val Ser Val His Pro Gln Ser Lys Lys 
    210                 215                 220                 


Glu His Ala Asp Asp Gln Glu Gly Gly Gln Phe Glu Val Lys Asp Val 
225                 230                 235                 240 


Glu Glu Thr Glu Leu Ser Ala Glu His Ser Pro Glu Thr Ala Glu Pro 
                245                 250                 255     


Ser Thr Asp Val Thr Ser Thr Glu Leu Thr Ser Glu Glu Pro Thr Pro 
            260                 265                 270         


Val Glu Val Pro Asp Lys Val Leu Pro Pro Ala Tyr Leu Glu Ala Thr 
        275                 280                 285             


Glu Pro Ala Val Thr His Asp Lys Asn Thr Cys Ile Ile Tyr Glu Ser 
    290                 295                 300                 


His Val 
305     


<210>  8622
<211>  279
<212>  PRT
<213>  Homo Sapiens

<400>  8622

Met Gly Glu Leu Ser Pro Leu Gln Arg Pro Leu Ala Thr Glu Gly Thr 
1               5                   10                  15      


Met Lys Ala Gln Gly Val Leu Leu Lys Leu Ala Leu Leu Ala Leu Pro 
            20                  25                  30          


Leu Leu Leu Leu Leu Ser Thr Pro Pro Cys Ala Pro Gln Val Ser Gly 
        35                  40                  45              


Ile Arg Gly Asp Ala Leu Glu Arg Phe Cys Leu Gln Gln Pro Leu Asp 
    50                  55                  60                  


Cys Asp Asp Ile Tyr Ala Gln Gly Tyr Gln Ser Asp Gly Val Tyr Leu 
65                  70                  75                  80  


Ile Tyr Pro Ser Gly Pro Ser Val Pro Val Pro Val Phe Cys Asp Met 
                85                  90                  95      


Thr Thr Glu Gly Gly Lys Trp Thr Val Phe Gln Lys Arg Phe Asn Gly 
            100                 105                 110         


Ser Val Ser Phe Phe Arg Gly Trp Asn Asp Tyr Lys Leu Gly Phe Gly 
        115                 120                 125             


Arg Ala Asp Gly Glu Tyr Trp Leu Gly Leu Gln Asn Met His Leu Leu 
    130                 135                 140                 


Thr Leu Lys Gln Lys Tyr Glu Leu Arg Val Asp Leu Glu Asp Phe Glu 
145                 150                 155                 160 


Asn Asn Thr Ala Tyr Ala Lys Tyr Ala Asp Phe Ser Ile Ser Pro Asn 
                165                 170                 175     


Ala Val Ser Ala Glu Glu Asp Gly Tyr Thr Leu Phe Val Ala Gly Phe 
            180                 185                 190         


Glu Asp Gly Gly Ala Gly Asp Ser Leu Ser Tyr His Ser Gly Gln Lys 
        195                 200                 205             


Phe Ser Thr Phe Asp Arg Asp Gln Asp Leu Phe Val Gln Asn Cys Ala 
    210                 215                 220                 


Ala Leu Ser Ser Gly Ala Phe Trp Phe Arg Ser Cys His Phe Ala Asn 
225                 230                 235                 240 


Leu Asn Gly Phe Tyr Leu Gly Gly Ser His Leu Ser Tyr Ala Asn Gly 
                245                 250                 255     


Ile Asn Trp Ala Gln Trp Lys Gly Phe Tyr Tyr Ser Leu Lys Arg Thr 
            260                 265                 270         


Glu Met Lys Ile Arg Arg Ala 
        275                 


<210>  8623
<211>  255
<212>  PRT
<213>  Homo Sapiens

<400>  8623

Met Lys Ala Leu Leu Ala Leu Pro Leu Leu Leu Leu Leu Ser Thr Pro 
1               5                   10                  15      


Pro Cys Ala Pro Gln Val Ser Gly Ile Arg Gly Asp Ala Leu Glu Arg 
            20                  25                  30          


Phe Cys Leu Gln Gln Pro Leu Asp Cys Asp Asp Ile Tyr Ala Gln Gly 
        35                  40                  45              


Tyr Gln Ser Asp Gly Val Tyr Leu Ile Tyr Pro Ser Gly Pro Ser Val 
    50                  55                  60                  


Pro Val Pro Val Phe Cys Asp Met Thr Thr Glu Gly Gly Lys Trp Thr 
65                  70                  75                  80  


Val Phe Gln Lys Arg Phe Asn Gly Ser Val Ser Phe Phe Arg Gly Trp 
                85                  90                  95      


Asn Asp Tyr Lys Leu Gly Phe Gly Arg Ala Asp Gly Glu Tyr Trp Leu 
            100                 105                 110         


Gly Leu Gln Asn Met His Leu Leu Thr Leu Lys Gln Lys Tyr Glu Leu 
        115                 120                 125             


Arg Val Asp Leu Glu Asp Phe Glu Asn Asn Thr Ala Tyr Ala Lys Tyr 
    130                 135                 140                 


Ala Asp Phe Ser Ile Ser Pro Asn Ala Val Ser Ala Glu Glu Asp Gly 
145                 150                 155                 160 


Tyr Thr Leu Phe Val Ala Gly Phe Glu Asp Gly Gly Ala Gly Asp Ser 
                165                 170                 175     


Leu Ser Tyr His Ser Gly Gln Lys Phe Ser Thr Phe Asp Arg Asp Gln 
            180                 185                 190         


Asp Leu Phe Val Gln Asn Cys Ala Ala Leu Ser Ser Gly Ala Phe Trp 
        195                 200                 205             


Phe Arg Ser Cys His Phe Ala Asn Leu Asn Gly Phe Tyr Leu Gly Gly 
    210                 215                 220                 


Ser His Leu Ser Tyr Ala Asn Gly Ile Asn Trp Ala Gln Trp Lys Gly 
225                 230                 235                 240 


Phe Tyr Tyr Ser Leu Lys Arg Thr Glu Met Lys Ile Arg Arg Ala 
                245                 250                 255 


<210>  8624
<211>  280
<212>  PRT
<213>  Homo Sapiens

<400>  8624

Met Val Gly Ala Asn Ala Lys Arg Thr Gly Asp Leu Trp Ser Trp Glu 
1               5                   10                  15      


Gly Ala Val Leu Thr Leu Ser Ala His Arg Gln Ala Leu Leu Ala Leu 
            20                  25                  30          


Pro Leu Leu Leu Leu Leu Ser Thr Pro Pro Cys Ala Pro Gln Val Ser 
        35                  40                  45              


Gly Ile Arg Gly Asp Ala Leu Glu Arg Phe Cys Leu Gln Gln Pro Leu 
    50                  55                  60                  


Asp Cys Asp Asp Ile Tyr Ala Gln Gly Tyr Gln Ser Asp Gly Val Tyr 
65                  70                  75                  80  


Leu Ile Tyr Pro Ser Gly Pro Ser Val Pro Val Pro Val Phe Cys Asp 
                85                  90                  95      


Met Thr Thr Glu Gly Gly Lys Trp Thr Val Phe Gln Lys Arg Phe Asn 
            100                 105                 110         


Gly Ser Val Ser Phe Phe Arg Gly Trp Asn Asp Tyr Lys Leu Gly Phe 
        115                 120                 125             


Gly Arg Ala Asp Gly Glu Tyr Trp Leu Gly Leu Gln Asn Met His Leu 
    130                 135                 140                 


Leu Thr Leu Lys Gln Lys Tyr Glu Leu Arg Val Asp Leu Glu Asp Phe 
145                 150                 155                 160 


Glu Asn Asn Thr Ala Tyr Ala Lys Tyr Ala Asp Phe Ser Ile Ser Pro 
                165                 170                 175     


Asn Ala Val Ser Ala Glu Glu Asp Gly Tyr Thr Leu Phe Val Ala Gly 
            180                 185                 190         


Phe Glu Asp Gly Gly Ala Gly Asp Ser Leu Ser Tyr His Ser Gly Gln 
        195                 200                 205             


Lys Phe Ser Thr Phe Asp Arg Asp Gln Asp Leu Phe Val Gln Asn Cys 
    210                 215                 220                 


Ala Ala Leu Ser Ser Gly Ala Phe Trp Phe Arg Ser Cys His Phe Ala 
225                 230                 235                 240 


Asn Leu Asn Gly Phe Tyr Leu Gly Gly Ser His Leu Ser Tyr Ala Asn 
                245                 250                 255     


Gly Ile Asn Trp Ala Gln Trp Lys Gly Phe Tyr Tyr Ser Leu Lys Arg 
            260                 265                 270         


Thr Glu Met Lys Ile Arg Arg Ala 
        275                 280 


<210>  8625
<211>  151
<212>  PRT
<213>  Homo Sapiens

<400>  8625

Met Ser Leu Leu Gly Pro Lys Val Leu Leu Phe Leu Ala Ala Phe Ile 
1               5                   10                  15      


Ile Thr Ser Asp Asp Val Thr Gln Ala Thr Pro Glu Thr Phe Thr Glu 
            20                  25                  30          


Asp Pro Asn Leu Val Asn Asp Pro Ala Thr Asp Glu Thr Val Leu Ala 
        35                  40                  45              


Val Leu Ala Asp Ile Ala Pro Ser Thr Asp Asp Leu Glu Cys Trp Asp 
    50                  55                  60                  


Glu Lys Phe Thr Cys Thr Arg Leu Tyr Ser Val His Arg Pro Val Lys 
65                  70                  75                  80  


Gln Cys Ile His Gln Leu Cys Phe Thr Ser Leu Arg Arg Met Tyr Ile 
                85                  90                  95      


Val Asn Lys Glu Ile Cys Ser Arg Leu Val Cys Lys Glu His Glu Ala 
            100                 105                 110         


Met Lys Asp Glu Leu Cys Arg Gln Met Ala Gly Leu Pro Pro Arg Arg 
        115                 120                 125             


Leu Arg Arg Ser Asn Tyr Phe Arg Leu Pro Pro Cys Glu Asn Val Asp 
    130                 135                 140                 


Leu Gln Arg Pro Asn Gly Leu 
145                 150     


<210>  8626
<211>  148
<212>  PRT
<213>  Homo Sapiens

<400>  8626

Met Ser Leu Leu Gly Pro Lys Val Leu Leu Phe Leu Ala Ala Phe Ile 
1               5                   10                  15      


Ile Thr Ser Asp Trp Ile Pro Leu Gly Val Asn Ser Gln Arg Gly Asp 
            20                  25                  30          


Asp Val Thr Gln Ala Thr Pro Glu Thr Phe Thr Glu Asp Pro Asn Leu 
        35                  40                  45              


Val Asn Asp Pro Ala Thr Asp Glu Thr Glu Cys Trp Asp Glu Lys Phe 
    50                  55                  60                  


Thr Cys Thr Arg Leu Tyr Ser Val His Arg Pro Val Lys Gln Cys Ile 
65                  70                  75                  80  


His Gln Leu Cys Phe Thr Ser Leu Arg Arg Met Tyr Ile Val Asn Lys 
                85                  90                  95      


Glu Ile Cys Ser Arg Leu Val Cys Lys Glu His Glu Ala Met Lys Asp 
            100                 105                 110         


Glu Leu Cys Arg Gln Met Ala Gly Leu Pro Pro Arg Arg Leu Arg Arg 
        115                 120                 125             


Ser Asn Tyr Phe Arg Leu Pro Pro Cys Glu Asn Val Asp Leu Gln Arg 
    130                 135                 140                 


Pro Asn Gly Leu 
145             


<210>  8627
<211>  91
<212>  PRT
<213>  Homo Sapiens

<400>  8627

Met Ser Leu Leu Gly Pro Lys Val Leu Leu Phe Leu Ala Ala Phe Ile 
1               5                   10                  15      


Ile Thr Ser Asp Trp Ile Pro Leu Gly Val Asn Ser Gln Arg Gly Asp 
            20                  25                  30          


Asp Val Thr Gln Ala Thr Pro Glu Thr Phe Thr Glu Asp Pro Asn Leu 
        35                  40                  45              


Val Asn Asp Pro Ala Thr Asp Glu Thr Val Leu Ala Val Leu Ala Asp 
    50                  55                  60                  


Ile Ala Pro Ser Thr Asp Asp Leu Ala Ser Leu Ser Glu Lys Asn Thr 
65                  70                  75                  80  


Thr Ala Glu Cys Trp Asp Glu Lys Phe Thr Cys 
                85                  90      


<210>  8628
<211>  173
<212>  PRT
<213>  Homo Sapiens

<400>  8628

Met Ser Leu Leu Gly Pro Lys Val Leu Leu Phe Leu Ala Ala Phe Ile 
1               5                   10                  15      


Ile Thr Ser Asp Trp Ile Pro Leu Gly Val Asn Ser Gln Arg Gly Asp 
            20                  25                  30          


Asp Val Thr Gln Ala Thr Pro Glu Thr Phe Thr Glu Asp Pro Asn Leu 
        35                  40                  45              


Val Asn Asp Pro Ala Thr Asp Glu Thr Val Leu Ala Val Leu Ala Asp 
    50                  55                  60                  


Ile Ala Pro Ser Thr Asp Asp Leu Ala Ser Leu Ser Glu Lys Asn Thr 
65                  70                  75                  80  


Thr Ala Glu Cys Trp Asp Glu Lys Phe Thr Cys Thr Arg Leu Tyr Ser 
                85                  90                  95      


Val His Arg Pro Val Lys Gln Cys Ile His Gln Leu Cys Phe Thr Ser 
            100                 105                 110         


Leu Arg Arg Met Tyr Ile Val Asn Lys Glu Ile Cys Ser Arg Leu Val 
        115                 120                 125             


Cys Lys Glu His Glu Ala Met Lys Asp Glu Leu Cys Arg Gln Met Ala 
    130                 135                 140                 


Gly Leu Pro Pro Arg Arg Leu Arg Arg Ser Asn Tyr Phe Arg Leu Pro 
145                 150                 155                 160 


Pro Cys Glu Asn Val Asp Leu Gln Arg Pro Asn Gly Leu 
                165                 170             


<210>  8629
<211>  138
<212>  PRT
<213>  Homo Sapiens

<400>  8629

Met Ser Leu Leu Gly Pro Lys Val Leu Leu Phe Leu Ala Ala Phe Ile 
1               5                   10                  15      


Ile Thr Ser Asp Trp Ile Pro Leu Gly Val Asn Ser Gln Arg Gly Asp 
            20                  25                  30          


Asp Val Thr Gln Ala Thr Pro Glu Thr Phe Thr Glu Asp Pro Asn Leu 
        35                  40                  45              


Val Asn Asp Pro Ala Thr Asp Glu Thr Val Leu Ala Val Leu Ala Asp 
    50                  55                  60                  


Ile Ala Pro Ser Thr Asp Asp Leu Ala Ser Leu Ser Glu Lys Asn Thr 
65                  70                  75                  80  


Thr Ala Glu Cys Trp Asp Glu Lys Phe Thr Cys Thr Arg Leu Tyr Ser 
                85                  90                  95      


Val His Arg Pro Val Lys Gln Cys Ile His Gln Leu Cys Phe Thr Ser 
            100                 105                 110         


Leu Arg Arg Met Tyr Ile Val Asn Lys Glu Ile Cys Ser Arg Leu Val 
        115                 120                 125             


Cys Lys Glu His Glu Ala Met Lys Asp Pro 
    130                 135             


<210>  8630
<211>  109
<212>  PRT
<213>  Homo Sapiens

<400>  8630

Met Ser Leu Leu Gly Pro Lys Val Leu Leu Phe Leu Ala Ala Phe Ile 
1               5                   10                  15      


Ile Thr Ser Asp Trp Ile Pro Leu Gly Val Asn Ser Gln Arg Gly Asp 
            20                  25                  30          


Asp Val Thr Gln Ala Thr Pro Glu Thr Phe Thr Glu Asp Pro Asn Leu 
        35                  40                  45              


Val Asn Asp Pro Ala Thr Asp Glu Thr Val Leu Ala Val Leu Ala Asp 
    50                  55                  60                  


Ile Ala Pro Ser Thr Asp Asp Leu Asp Glu Leu Cys Arg Gln Met Ala 
65                  70                  75                  80  


Gly Leu Pro Pro Arg Arg Leu Arg Arg Ser Asn Tyr Phe Arg Leu Pro 
                85                  90                  95      


Pro Cys Glu Asn Val Asp Leu Gln Arg Pro Asn Gly Leu 
            100                 105                 


<210>  8631
<211>  163
<212>  PRT
<213>  Homo Sapiens

<400>  8631

Met Ser Leu Leu Gly Pro Lys Val Leu Leu Phe Leu Ala Ala Phe Ile 
1               5                   10                  15      


Ile Thr Ser Asp Trp Ile Pro Leu Gly Val Asn Ser Gln Arg Gly Asp 
            20                  25                  30          


Asp Val Thr Gln Ala Thr Pro Glu Thr Phe Thr Glu Asp Pro Asn Leu 
        35                  40                  45              


Val Asn Asp Pro Ala Thr Asp Glu Thr Val Leu Ala Val Leu Ala Asp 
    50                  55                  60                  


Ile Ala Pro Ser Thr Asp Asp Leu Glu Cys Trp Asp Glu Lys Phe Thr 
65                  70                  75                  80  


Cys Thr Arg Leu Tyr Ser Val His Arg Pro Val Lys Gln Cys Ile His 
                85                  90                  95      


Gln Leu Cys Phe Thr Ser Leu Arg Arg Met Tyr Ile Val Asn Lys Glu 
            100                 105                 110         


Ile Cys Ser Arg Leu Val Cys Lys Glu His Glu Ala Met Lys Asp Glu 
        115                 120                 125             


Leu Cys Arg Gln Met Ala Gly Leu Pro Pro Arg Arg Leu Arg Arg Ser 
    130                 135                 140                 


Asn Tyr Phe Arg Leu Pro Pro Cys Glu Asn Val Asp Leu Gln Arg Pro 
145                 150                 155                 160 


Asn Gly Leu 
            


<210>  8632
<211>  163
<212>  PRT
<213>  Homo Sapiens

<400>  8632

Met Ser Leu Leu Gly Pro Lys Val Leu Leu Phe Leu Ala Ala Phe Ile 
1               5                   10                  15      


Ile Thr Ser Asp Trp Ile Pro Leu Gly Val Asn Ser Gln Arg Gly Asp 
            20                  25                  30          


Asp Val Thr Gln Ala Thr Pro Glu Thr Phe Thr Glu Asp Pro Asn Leu 
        35                  40                  45              


Val Asn Asp Pro Ala Thr Asp Glu Thr Val Leu Ala Val Leu Ala Asp 
    50                  55                  60                  


Ile Ala Pro Ser Thr Asp Asp Leu Glu Cys Trp Asp Glu Lys Phe Thr 
65                  70                  75                  80  


Cys Thr Arg Leu Tyr Ser Val His Arg Pro Val Lys Gln Cys Ile His 
                85                  90                  95      


Gln Leu Cys Phe Thr Ser Leu Arg Arg Met Tyr Ile Val Asn Lys Glu 
            100                 105                 110         


Ile Cys Ser Arg Leu Val Cys Lys Glu His Glu Ala Met Lys Asp Glu 
        115                 120                 125             


Leu Cys Arg Gln Met Ala Gly Leu Pro Pro Arg Arg Leu Arg Arg Ser 
    130                 135                 140                 


Asn Tyr Phe Arg Leu Pro Pro Cys Glu Asn Val Asp Leu Gln Arg Pro 
145                 150                 155                 160 


Asn Gly Leu 
            


<210>  8633
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  8633

Met Ser Leu Leu Gly Pro Lys Val Leu Leu Phe Leu Ala Ala Phe Ile 
1               5                   10                  15      


Ile Thr Ser Asp Trp Ile Pro Leu Gly Val Asn Ser Gln Arg Gly Asp 
            20                  25                  30          


Asp Val Thr Gln Ala Thr Pro Glu Thr Phe Thr Glu Asp Pro Asn Leu 
        35                  40                  45              


Val Asn Asp Pro Ala Thr Asp Glu Thr Val Leu Ala Val Leu Ala Asp 
    50                  55                  60                  


Ile Ala Pro Ser Thr Asp Asp Leu Glu Cys Trp Asp Glu Lys Phe Thr 
65                  70                  75                  80  


Cys Thr Arg Leu Tyr Ser Val His Arg Pro Val Lys Gln Cys Ile His 
                85                  90                  95      


Gln Leu Cys Phe Thr Ser Leu Arg Arg Met Tyr Ile Val Asn Lys Glu 
            100                 105                 110         


Ile Cys Ser Arg Leu Val Cys Lys Glu His Glu Ala Met Lys Asp Pro 
        115                 120                 125             


<210>  8634
<211>  163
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8634

Xaa Leu Ala Ala Phe Ile Ile Thr Ser Asp Trp Ile Pro Leu Gly Val 
1               5                   10                  15      


Asn Ser Gln Arg Gly Asp Asp Val Thr Gln Ala Thr Pro Glu Thr Phe 
            20                  25                  30          


Thr Glu Asp Pro Asn Leu Val Asn Asp Pro Ala Thr Asp Glu Thr Val 
        35                  40                  45              


Leu Ala Val Leu Ala Asp Ile Ala Pro Ser Thr Asp Asp Leu Ala Ser 
    50                  55                  60                  


Leu Ser Glu Lys Asn Thr Thr Ala Glu Cys Trp Asp Glu Lys Phe Thr 
65                  70                  75                  80  


Cys Thr Arg Leu Tyr Ser Val His Arg Pro Val Lys Gln Cys Ile His 
                85                  90                  95      


Gln Leu Cys Phe Thr Ser Leu Arg Arg Met Tyr Ile Val Asn Lys Glu 
            100                 105                 110         


Ile Cys Ser Arg Leu Val Cys Lys Glu His Glu Ala Met Lys Asp Glu 
        115                 120                 125             


Leu Cys Arg Gln Met Ala Gly Leu Pro Pro Arg Arg Leu Arg Arg Ser 
    130                 135                 140                 


Asn Tyr Phe Arg Leu Pro Pro Cys Glu Asn Val Asp Leu Gln Arg Pro 
145                 150                 155                 160 


Asn Gly Leu 
            


<210>  8635
<211>  79
<212>  PRT
<213>  Homo Sapiens

<400>  8635

Tyr Ser Val His Arg Pro Val Lys Gln Cys Ile His Gln Leu Cys Phe 
1               5                   10                  15      


Thr Ser Leu Arg Arg Met Tyr Ile Val Asn Lys Glu Ile Cys Ser Arg 
            20                  25                  30          


Leu Val Cys Lys Glu His Glu Ala Met Lys Asp Glu Leu Cys Arg Gln 
        35                  40                  45              


Met Ala Gly Leu Pro Pro Arg Arg Leu Arg Arg Ser Asn Tyr Phe Arg 
    50                  55                  60                  


Leu Pro Pro Cys Glu Asn Val Asp Leu Gln Arg Pro Asn Gly Leu 
65                  70                  75                  


<210>  8636
<211>  75
<212>  PRT
<213>  Homo Sapiens

<400>  8636

Phe Asp Phe Ile His Asp Val Asn Lys Lys His Lys Glu Phe Val Gly 
1               5                   10                  15      


Asn Trp Asn Lys Asn Ala Val His Val Asn Leu Phe Glu Thr Pro Val 
            20                  25                  30          


Glu Ala Gln Tyr Val Arg Leu Tyr Pro Thr Ser Cys His Thr Ala Cys 
        35                  40                  45              


Thr Leu Arg Phe Glu Leu Leu Gly Cys Glu Leu Asn Ala Arg Lys Ala 
    50                  55                  60                  


Asp Leu Arg Arg Gly Ala Asp Asp Arg Glu Gln 
65                  70                  75  


<210>  8637
<211>  268
<212>  PRT
<213>  Homo Sapiens

<400>  8637

Met Pro Arg Pro Arg Leu Leu Ala Ala Leu Cys Gly Ala Leu Leu Cys 
1               5                   10                  15      


Ala Pro Ser Leu Leu Val Ala Leu Asp Ile Cys Ser Lys Asn Pro Cys 
            20                  25                  30          


His Asn Gly Gly Leu Cys Glu Glu Ile Ser Gln Glu Val Arg Gly Asp 
        35                  40                  45              


Val Phe Pro Ser Tyr Thr Cys Thr Cys Leu Lys Gly Tyr Ala Gly Asn 
    50                  55                  60                  


His Cys Glu Thr Lys Cys Val Glu Pro Leu Gly Leu Glu Asn Gly Asn 
65                  70                  75                  80  


Ile Ala Asn Ser Gln Ile Ala Ala Ser Ser Val Arg Val Thr Phe Leu 
                85                  90                  95      


Gly Leu Gln His Trp Val Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly 
            100                 105                 110         


Met Val Asn Ala Trp Thr Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile 
        115                 120                 125             


Gln Val Asn Leu Leu Arg Arg Met Trp Val Thr Gly Val Val Thr Gln 
    130                 135                 140                 


Gly Ala Ser Arg Leu Ala Ser His Glu Tyr Leu Lys Ala Phe Lys Val 
145                 150                 155                 160 


Ala Tyr Ser Leu Asn Gly His Glu Phe Asp Phe Ile His Asp Val Asn 
                165                 170                 175     


Lys Lys His Lys Glu Phe Val Gly Asn Trp Asn Lys Asn Ala Val His 
            180                 185                 190         


Val Asn Leu Phe Glu Thr Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr 
        195                 200                 205             


Pro Thr Ser Cys His Thr Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly 
    210                 215                 220                 


Cys Glu Leu Asn Ala Ala Thr Arg Pro Gly Ala Cys Ile Ser Ser Ala 
225                 230                 235                 240 


Gly Thr Pro Pro Met His Gly Trp Thr Ser Arg Ala Thr Ser Thr Pro 
                245                 250                 255     


Gly Leu Arg Gly Ala Thr Val Thr Ile Ser Gly Cys 
            260                 265             


<210>  8638
<211>  335
<212>  PRT
<213>  Homo Sapiens

<400>  8638

Met Pro Arg Pro Arg Leu Leu Ala Ala Leu Cys Gly Ala Leu Leu Cys 
1               5                   10                  15      


Ala Pro Ser Leu Leu Val Ala Leu Asp Ile Cys Ser Lys Asn Pro Cys 
            20                  25                  30          


His Asn Gly Gly Leu Cys Glu Glu Ile Ser Gln Glu Val Arg Gly Asp 
        35                  40                  45              


Val Phe Pro Ser Tyr Thr Cys Thr Cys Leu Lys Gly Tyr Ala Gly Asn 
    50                  55                  60                  


His Cys Glu Thr Lys Cys Val Glu Pro Leu Gly Leu Glu Asn Gly Asn 
65                  70                  75                  80  


Ile Ala Asn Ser Gln Ile Ala Ala Ser Ser Val Arg Val Thr Phe Leu 
                85                  90                  95      


Gly Leu Gln His Trp Val Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly 
            100                 105                 110         


Met Val Asn Ala Trp Thr Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile 
        115                 120                 125             


Gln Val Asn Leu Leu Arg Arg Met Trp Val Thr Gly Val Val Thr Gln 
    130                 135                 140                 


Gly Ala Ser Arg Leu Ala Ser His Glu Tyr Leu Lys Ala Phe Lys Val 
145                 150                 155                 160 


Ala Tyr Ser Leu Asn Gly His Glu Phe Asp Phe Ile His Asp Val Asn 
                165                 170                 175     


Lys Lys His Lys Glu Phe Val Gly Asn Trp Asn Lys Asn Ala Val His 
            180                 185                 190         


Val Asn Leu Phe Glu Thr Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr 
        195                 200                 205             


Pro Thr Ser Cys His Thr Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly 
    210                 215                 220                 


Cys Glu Leu Asn Gly Cys Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser 
225                 230                 235                 240 


Ile Pro Asp Lys Gln Ile Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly 
                245                 250                 255     


Leu His Leu Phe Ser Trp Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln 
            260                 265                 270         


Gly Asn Phe Asn Ala Trp Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp 
        275                 280                 285             


Leu Gln Ile Phe Pro Gly Asn Trp Asp Asn His Ser His Lys Lys Asn 
    290                 295                 300                 


Leu Phe Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg Ile Leu Pro Val 
305                 310                 315                 320 


Ala Trp His Asn Arg Ile Ala Leu Arg Leu Glu Leu Leu Gly Cys 
                325                 330                 335 


<210>  8639
<211>  387
<212>  PRT
<213>  Homo Sapiens

<400>  8639

Met Pro Arg Pro Arg Leu Leu Ala Ala Leu Cys Gly Ala Leu Leu Cys 
1               5                   10                  15      


Ala Pro Ser Leu Leu Val Ala Leu Asp Ile Cys Ser Lys Asn Pro Cys 
            20                  25                  30          


His Asn Gly Gly Leu Cys Glu Glu Ile Ser Gln Glu Val Arg Gly Asp 
        35                  40                  45              


Val Phe Pro Ser Tyr Thr Cys Thr Cys Leu Lys Gly Tyr Ala Gly Asn 
    50                  55                  60                  


His Cys Glu Thr Lys Cys Val Glu Pro Leu Gly Leu Glu Asn Gly Asn 
65                  70                  75                  80  


Ile Ala Asn Ser Gln Ile Ala Ala Ser Ser Val Arg Val Thr Phe Leu 
                85                  90                  95      


Gly Leu Gln His Trp Val Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly 
            100                 105                 110         


Met Val Asn Ala Trp Thr Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile 
        115                 120                 125             


Gln Val Asn Leu Leu Arg Arg Met Trp Val Thr Gly Val Val Thr Gln 
    130                 135                 140                 


Gly Ala Ser Arg Leu Ala Ser His Glu Tyr Leu Lys Ala Phe Lys Val 
145                 150                 155                 160 


Ala Tyr Ser Leu Asn Gly His Glu Phe Asp Phe Ile His Asp Val Asn 
                165                 170                 175     


Lys Lys His Lys Glu Phe Val Gly Asn Trp Asn Lys Asn Ala Val His 
            180                 185                 190         


Val Asn Leu Phe Glu Thr Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr 
        195                 200                 205             


Pro Thr Ser Cys His Thr Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly 
    210                 215                 220                 


Cys Glu Leu Asn Gly Cys Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser 
225                 230                 235                 240 


Ile Pro Asp Lys Gln Ile Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly 
                245                 250                 255     


Leu His Leu Phe Ser Trp Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln 
            260                 265                 270         


Gly Asn Phe Asn Ala Trp Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp 
        275                 280                 285             


Leu Gln Val Asp Leu Gly Ser Ser Lys Glu Val Thr Gly Ile Ile Thr 
    290                 295                 300                 


Gln Gly Ala Arg Asn Phe Gly Ser Val Gln Phe Val Ala Ser Tyr Lys 
305                 310                 315                 320 


Val Ala Tyr Ser Asn Asp Ser Ala Asn Trp Thr Glu Tyr Gln Asp Pro 
                325                 330                 335     


Arg Thr Gly Ser Ser Lys Ile Phe Pro Gly Asn Trp Asp Asn His Ser 
            340                 345                 350         


His Lys Lys Asn Leu Phe Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg 
        355                 360                 365             


Ile Leu Pro Val Ala Trp His Asn Arg Ile Ala Leu Arg Leu Glu Leu 
    370                 375                 380                 


Leu Gly Cys 
385         


<210>  8640
<211>  387
<212>  PRT
<213>  Homo Sapiens

<400>  8640

Met Pro Arg Pro Arg Leu Leu Ala Ala Leu Cys Gly Ala Leu Leu Cys 
1               5                   10                  15      


Ala Pro Ser Leu Leu Val Ala Leu Asp Ile Cys Ser Lys Asn Pro Cys 
            20                  25                  30          


His Asn Gly Gly Leu Cys Glu Glu Ile Ser Gln Glu Val Arg Gly Asp 
        35                  40                  45              


Val Phe Pro Ser Tyr Thr Cys Thr Cys Leu Lys Gly Tyr Ala Gly Asn 
    50                  55                  60                  


His Cys Glu Thr Lys Cys Val Glu Pro Leu Gly Leu Glu Asn Gly Asn 
65                  70                  75                  80  


Ile Ala Asn Ser Gln Ile Ala Ala Ser Ser Val Arg Val Thr Phe Leu 
                85                  90                  95      


Gly Leu Gln His Trp Val Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly 
            100                 105                 110         


Met Val Asn Ala Trp Thr Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile 
        115                 120                 125             


Gln Val Asn Leu Leu Arg Arg Met Trp Val Thr Gly Val Val Thr Gln 
    130                 135                 140                 


Gly Ala Ser Arg Leu Ala Ser His Glu Tyr Leu Lys Ala Phe Lys Val 
145                 150                 155                 160 


Ala Tyr Ser Leu Asn Gly His Glu Phe Asp Phe Ile His Asp Val Asn 
                165                 170                 175     


Lys Lys His Lys Glu Phe Val Gly Asn Trp Asn Lys Asn Ala Val His 
            180                 185                 190         


Val Asn Leu Phe Glu Thr Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr 
        195                 200                 205             


Pro Thr Ser Cys His Thr Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly 
    210                 215                 220                 


Cys Glu Leu Asn Gly Cys Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser 
225                 230                 235                 240 


Ile Pro Asp Lys Gln Ile Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly 
                245                 250                 255     


Leu His Leu Phe Ser Trp Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln 
            260                 265                 270         


Gly Asn Phe Asn Ala Trp Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp 
        275                 280                 285             


Leu Gln Val Asp Leu Gly Ser Ser Lys Glu Val Thr Gly Ile Ile Thr 
    290                 295                 300                 


Gln Gly Ala Arg Asn Phe Gly Ser Val Gln Phe Val Ala Ser Tyr Lys 
305                 310                 315                 320 


Val Ala Tyr Ser Asn Asp Ser Ala Asn Trp Thr Glu Tyr Gln Asp Pro 
                325                 330                 335     


Arg Thr Gly Ser Ser Lys Ile Phe Pro Gly Asn Trp Asp Asn His Ser 
            340                 345                 350         


His Lys Lys Asn Leu Phe Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg 
        355                 360                 365             


Ile Leu Pro Val Ala Trp His Asn Arg Ile Ala Leu Arg Leu Glu Leu 
    370                 375                 380                 


Leu Gly Cys 
385         


<210>  8641
<211>  343
<212>  PRT
<213>  Homo Sapiens

<400>  8641

Met Pro Arg Pro Arg Leu Leu Ala Ala Leu Cys Gly Ala Leu Leu Cys 
1               5                   10                  15      


Ala Pro Ser Leu Leu Val Ala Leu Glu Cys Val Glu Pro Leu Gly Leu 
            20                  25                  30          


Glu Asn Gly Asn Ile Ala Asn Ser Gln Ile Ala Ala Ser Ser Val Arg 
        35                  40                  45              


Val Thr Phe Leu Gly Leu Gln His Trp Val Pro Glu Leu Ala Arg Leu 
    50                  55                  60                  


Asn Arg Ala Gly Met Val Asn Ala Trp Thr Pro Ser Ser Asn Asp Asp 
65                  70                  75                  80  


Asn Pro Trp Ile Gln Val Asn Leu Leu Arg Arg Met Trp Val Thr Gly 
                85                  90                  95      


Val Val Thr Gln Gly Ala Ser Arg Leu Ala Ser His Glu Tyr Leu Lys 
            100                 105                 110         


Ala Phe Lys Val Ala Tyr Ser Leu Asn Gly His Glu Phe Asp Phe Ile 
        115                 120                 125             


His Asp Val Asn Lys Lys His Lys Glu Phe Val Gly Asn Trp Asn Lys 
    130                 135                 140                 


Asn Ala Val His Val Asn Leu Phe Glu Thr Pro Val Glu Ala Gln Tyr 
145                 150                 155                 160 


Val Arg Leu Tyr Pro Thr Ser Cys His Thr Ala Cys Thr Leu Arg Phe 
                165                 170                 175     


Glu Leu Leu Gly Cys Glu Leu Asn Gly Cys Ala Asn Pro Leu Gly Leu 
            180                 185                 190         


Lys Asn Asn Ser Ile Pro Asp Lys Gln Ile Thr Ala Ser Ser Ser Tyr 
        195                 200                 205             


Lys Thr Trp Gly Leu His Leu Phe Ser Trp Asn Pro Ser Tyr Ala Arg 
    210                 215                 220                 


Leu Asp Lys Gln Gly Asn Phe Asn Ala Trp Val Ala Gly Ser Tyr Gly 
225                 230                 235                 240 


Asn Asp Gln Trp Leu Gln Val Asp Leu Gly Ser Ser Lys Glu Val Thr 
                245                 250                 255     


Gly Ile Ile Thr Gln Gly Ala Arg Asn Phe Gly Ser Val Gln Phe Val 
            260                 265                 270         


Ala Ser Tyr Lys Val Ala Tyr Ser Asn Asp Ser Ala Asn Trp Thr Glu 
        275                 280                 285             


Tyr Gln Asp Pro Arg Thr Gly Ser Ser Lys Ile Phe Pro Gly Asn Trp 
    290                 295                 300                 


Asp Asn His Ser His Lys Lys Asn Leu Phe Glu Thr Pro Ile Leu Ala 
305                 310                 315                 320 


Arg Tyr Val Arg Ile Leu Pro Val Ala Trp His Asn Arg Ile Ala Leu 
                325                 330                 335     


Arg Leu Glu Leu Leu Gly Cys 
            340             


<210>  8642
<211>  25
<212>  PRT
<213>  Homo Sapiens

<400>  8642

Met Pro Arg Pro Arg Leu Leu Ala Ala Leu Cys Gly Ala Leu Leu Cys 
1               5                   10                  15      


Ala Pro Ser Leu Leu Val Ala Leu Gly 
            20                  25  


<210>  8643
<211>  43
<212>  PRT
<213>  Homo Sapiens

<400>  8643

Met Ala Ala Glu Phe Asp Thr Phe Leu Ala Ser Gly Leu Arg Trp Phe 
1               5                   10                  15      


Cys His Val Asp Asp Asp Asn Tyr Val Asn Pro Arg Ala Leu Leu Gln 
            20                  25                  30          


Leu Leu Arg Ala Phe Pro Leu Ala Arg Asp Val 
        35                  40              


<210>  8644
<211>  132
<212>  PRT
<213>  Homo Sapiens

<400>  8644

Met Ala Ala Glu Phe Asp Thr Phe Leu Ala Ser Gly Leu Arg Trp Phe 
1               5                   10                  15      


Cys His Val Asp Asp Asp Asn Tyr Val Asn Pro Arg Ala Leu Leu Gln 
            20                  25                  30          


Leu Leu Arg Ala Phe Pro Leu Ala Arg Asp Val Tyr Val Gly Arg Pro 
        35                  40                  45              


Ser Leu Asn Arg Pro Ile His Ala Ser Glu Pro Gln Pro His Asn Arg 
    50                  55                  60                  


Thr Arg Leu Val Gln Phe Trp Phe Ala Thr Gly Gly Ala Gly Phe Cys 
65                  70                  75                  80  


Ile Asn Arg Lys Leu Ala Leu Lys Met Ala Pro Trp Ala Ser Gly Ser 
                85                  90                  95      


Arg Phe Met Asp Thr Ser Ala Leu Ile Arg Leu Pro Asp Asp Cys Thr 
            100                 105                 110         


Met Gly Tyr Ile Ile Glu Cys Lys Leu Gly Gly Arg Leu Gln Pro Ser 
        115                 120                 125             


Pro Leu Phe His 
    130         


<210>  8645
<211>  130
<212>  PRT
<213>  Homo Sapiens

<400>  8645

Met Gln Cys Arg Leu Pro Arg Gly Leu Ala Gly Ala Leu Leu Thr Leu 
1               5                   10                  15      


Leu Cys Met Gly Leu Leu Cys Leu Arg Tyr His Leu Asn Leu Ser Pro 
            20                  25                  30          


Gln Arg Val Gln Gly Thr Pro Glu Leu Ser Gln Pro Asn Pro Gly Pro 
        35                  40                  45              


Pro Lys Leu Gln Leu His Asp Val Phe Ile Ala Val Lys Thr Thr Arg 
    50                  55                  60                  


Ala Phe His Arg Leu Arg Leu Glu Leu Leu Leu Asp Thr Trp Val Ser 
65                  70                  75                  80  


Arg Thr Arg Glu Gln Gly Pro Thr Leu Trp Ser Pro Thr Ala Pro Arg 
                85                  90                  95      


Asn Thr Ala Thr Gln Leu Cys Pro Ala Arg Trp Leu Leu Ser Ser Thr 
            100                 105                 110         


Pro Ser Trp Pro Val Gly Leu Gly Gly Ser Ala Met Trp Thr Met Thr 
        115                 120                 125             


Thr Met 
    130 


<210>  8646
<211>  321
<212>  PRT
<213>  Homo Sapiens

<400>  8646

Met Gln Cys Arg Leu Pro Arg Gly Leu Ala Gly Ala Leu Leu Thr Leu 
1               5                   10                  15      


Leu Cys Met Gly Leu Leu Cys Leu Arg Tyr His Leu Asn Leu Ser Pro 
            20                  25                  30          


Gln Arg Val Gln Gly Thr Pro Glu Leu Ser Gln Pro Asn Pro Gly Pro 
        35                  40                  45              


Pro Lys Leu Gln Leu His Asp Val Phe Ile Ala Val Lys Thr Thr Arg 
    50                  55                  60                  


Ala Phe His Arg Leu Arg Leu Glu Leu Leu Leu Asp Thr Trp Val Ser 
65                  70                  75                  80  


Arg Thr Arg Glu Gln Thr Phe Val Phe Thr Asp Ser Pro Asp Lys Gly 
                85                  90                  95      


Leu Gln Glu Arg Leu Gly Ser His Leu Val Val Thr Asn Cys Ser Ala 
            100                 105                 110         


Glu His Ser His Pro Ala Leu Ser Cys Lys Met Ala Ala Glu Phe Asp 
        115                 120                 125             


Thr Phe Leu Ala Ser Gly Leu Arg Trp Phe Cys His Val Asp Asp Asp 
    130                 135                 140                 


Asn Tyr Val Asn Pro Arg Ala Leu Leu Gln Leu Leu Arg Ala Phe Pro 
145                 150                 155                 160 


Leu Ala Arg Asp Val Tyr Val Gly Arg Pro Ser Leu Asn Arg Pro Ile 
                165                 170                 175     


His Ala Ser Glu Pro Gln Pro His Asn Arg Thr Arg Leu Val Gln Phe 
            180                 185                 190         


Trp Phe Ala Thr Gly Gly Ala Gly Phe Cys Ile Asn Arg Lys Leu Ala 
        195                 200                 205             


Leu Lys Met Ala Pro Trp Ala Ser Gly Ser Arg Phe Met Asp Thr Ser 
    210                 215                 220                 


Ala Leu Ile Arg Leu Pro Asp Asp Cys Thr Met Gly Tyr Ile Ile Glu 
225                 230                 235                 240 


Cys Lys Leu Gly Gly Arg Leu Gln Pro Ser Pro Leu Phe His Ser His 
                245                 250                 255     


Leu Glu Thr Leu Gln Leu Leu Arg Thr Ala Gln Leu Pro Glu Gln Val 
            260                 265                 270         


Thr Leu Ser Tyr Gly Val Phe Glu Gly Lys Leu Asn Val Ile Lys Leu 
        275                 280                 285             


Gln Gly Pro Phe Ser Pro Glu Glu Asp Pro Ser Arg Phe Arg Ser Leu 
    290                 295                 300                 


His Cys Leu Leu Tyr Pro Asp Thr Pro Trp Cys Pro Gln Leu Gly Ala 
305                 310                 315                 320 


Arg 
    


<210>  8647
<211>  118
<212>  PRT
<213>  Homo Sapiens

<400>  8647

Met Gln Cys Arg Leu Pro Arg Gly Leu Ala Gly Ala Leu Leu Thr Leu 
1               5                   10                  15      


Leu Cys Met Gly Leu Leu Cys Leu Arg Tyr His Leu Asn Leu Ser Pro 
            20                  25                  30          


Gln Arg Val Gln Gly Thr Pro Glu Leu Ser Gln Pro Asn Pro Gly Pro 
        35                  40                  45              


Pro Lys Leu Gln Leu His Asp Val Phe Ile Ala Val Lys Thr Thr Arg 
    50                  55                  60                  


Ala Phe His Arg Leu Arg Leu Glu Leu Leu Leu Asp Thr Trp Val Ser 
65                  70                  75                  80  


Arg Thr Arg Glu Gln Thr Phe Val Phe Thr Asp Ser Pro Asp Lys Gly 
                85                  90                  95      


Leu Gln Glu Arg Leu Gly Ser Pro Asp Ser Ser Ser Leu Leu Gln Gly 
            100                 105                 110         


Pro Thr Leu Trp Ser Pro 
        115             


<210>  8648
<211>  127
<212>  PRT
<213>  Homo Sapiens

<400>  8648

Met Gln Cys Arg Leu Pro Arg Gly Leu Ala Gly Ala Leu Leu Thr Leu 
1               5                   10                  15      


Leu Cys Met Gly Leu Leu Cys Leu Arg Tyr His Leu Asn Leu Ser Pro 
            20                  25                  30          


Gln Arg Val Gln Gly Thr Pro Glu Leu Ser Gln Pro Asn Pro Gly Pro 
        35                  40                  45              


Pro Lys Leu Gln Leu His Asp Val Phe Ile Ala Val Lys Thr Thr Arg 
    50                  55                  60                  


Ala Phe His Arg Leu Arg Leu Glu Leu Leu Leu Asp Thr Trp Val Ser 
65                  70                  75                  80  


Arg Thr Arg Glu Gln Val Thr Asn Ile Cys Leu His Arg Gln Pro Arg 
                85                  90                  95      


Gln Arg Pro Pro Gly Glu Thr Gly Val Pro Pro Cys Gly His Gln Leu 
            100                 105                 110         


Leu Arg Gly Thr Gln Pro Pro Ser Ser Val Leu Gln Asp Gly Cys 
        115                 120                 125         


<210>  8649
<211>  307
<212>  PRT
<213>  Homo Sapiens

<400>  8649

Met Gln Cys Arg Leu Pro Arg Gly Leu Ala Gly Ala Leu Leu Thr Leu 
1               5                   10                  15      


Leu Cys Met Gly Leu Leu Cys Leu Arg Tyr His Leu Asn Leu Ser Pro 
            20                  25                  30          


Gln Arg Val Gln Gly Thr Pro Glu Leu Ser Gln Pro Asn Pro Gly Pro 
        35                  40                  45              


Pro Lys Leu Gln Leu His Asp Val Phe Ile Ala Val Lys Thr Thr Arg 
    50                  55                  60                  


Ala Phe His Arg Leu Arg Leu Glu Leu Leu Leu Asp Thr Trp Val Ser 
65                  70                  75                  80  


Arg Thr Arg Glu Gln Val Thr Arg Ser His Leu Val Val Thr Asn Cys 
                85                  90                  95      


Ser Ala Glu His Ser His Pro Ala Leu Ser Cys Lys Met Ala Ala Glu 
            100                 105                 110         


Phe Asp Thr Phe Leu Ala Ser Gly Leu Arg Trp Phe Cys His Val Asp 
        115                 120                 125             


Asp Asp Asn Tyr Val Asn Pro Arg Ala Leu Leu Gln Leu Leu Arg Ala 
    130                 135                 140                 


Phe Pro Leu Ala Arg Asp Val Tyr Val Gly Arg Pro Ser Leu Asn Arg 
145                 150                 155                 160 


Pro Ile His Ala Ser Glu Pro Gln Pro His Asn Arg Thr Arg Leu Val 
                165                 170                 175     


Gln Phe Trp Phe Ala Thr Gly Gly Ala Gly Phe Cys Ile Asn Arg Lys 
            180                 185                 190         


Leu Ala Leu Lys Met Ala Pro Trp Ala Ser Gly Ser Arg Phe Met Asp 
        195                 200                 205             


Thr Ser Ala Leu Ile Arg Leu Pro Asp Asp Cys Thr Met Gly Tyr Ile 
    210                 215                 220                 


Ile Glu Cys Lys Leu Gly Gly Arg Leu Gln Pro Ser Pro Leu Phe His 
225                 230                 235                 240 


Ser His Leu Glu Thr Leu Gln Leu Leu Arg Thr Ala Gln Leu Pro Glu 
                245                 250                 255     


Gln Val Thr Leu Ser Tyr Gly Val Phe Glu Gly Lys Leu Asn Val Ile 
            260                 265                 270         


Lys Leu Gln Gly Pro Phe Ser Pro Glu Glu Asp Pro Ser Arg Phe Arg 
        275                 280                 285             


Ser Leu His Cys Leu Leu Tyr Pro Asp Thr Pro Trp Cys Pro Gln Leu 
    290                 295                 300                 


Gly Ala Arg 
305         


<210>  8650
<211>  87
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8650

Xaa Ser His Leu Glu Thr Leu Gln Leu Leu Arg Thr Ala Gln Leu Pro 
1               5                   10                  15      


Glu Gln Ile Ser Leu Pro Pro Leu Ser Ala Leu Ser Arg Tyr Thr Leu 
            20                  25                  30          


Val Ser Pro Ala Gly Cys Pro Met Asn Pro Glu Leu Leu Gly Lys Gly 
        35                  40                  45              


Trp Ala Glu Thr Ser Gly Cys Ala Leu Ala Pro Lys Val Ala Leu Trp 
    50                  55                  60                  


Val Pro Gly Lys Cys Leu Val Ile Gly Ser Pro Trp Gln Gly Leu Arg 
65                  70                  75                  80  


Val Val Gly Lys Pro Arg Ile 
                85          


<210>  8651
<211>  3065
<212>  PRT
<213>  Homo Sapiens

<400>  8651

Met Glu Glu Lys Gln Gln Ile Ile Leu Ala Asn Gln Asp Gly Gly Thr 
1               5                   10                  15      


Val Ala Gly Ala Ala Pro Thr Phe Phe Val Ile Leu Lys Gln Pro Gly 
            20                  25                  30          


Asn Gly Lys Thr Asp Gln Gly Ile Leu Val Thr Asn Gln Asp Ala Cys 
        35                  40                  45              


Ala Leu Ala Ser Ser Val Ser Ser Pro Val Lys Ser Lys Gly Lys Ile 
    50                  55                  60                  


Cys Leu Pro Ala Asp Cys Thr Val Gly Gly Ile Thr Val Thr Leu Asp 
65                  70                  75                  80  


Asn Asn Ser Met Trp Asn Glu Phe Tyr His Arg Ser Thr Glu Met Ile 
                85                  90                  95      


Leu Thr Lys Gln Gly Arg Arg Met Phe Pro Tyr Cys Arg Tyr Trp Ile 
            100                 105                 110         


Thr Gly Leu Asp Ser Asn Leu Lys Tyr Ile Leu Val Met Asp Ile Ser 
        115                 120                 125             


Pro Val Asp Asn His Arg Tyr Lys Trp Asn Gly Arg Trp Trp Glu Pro 
    130                 135                 140                 


Ser Gly Lys Ala Glu Pro His Val Leu Gly Arg Val Phe Ile His Pro 
145                 150                 155                 160 


Glu Ser Pro Ser Thr Gly His Tyr Trp Met His Gln Pro Val Ser Phe 
                165                 170                 175     


Tyr Lys Leu Lys Leu Thr Asn Asn Thr Leu Asp Gln Glu Gly His Ile 
            180                 185                 190         


Ile Leu His Ser Met His Arg Tyr Leu Pro Arg Leu His Leu Val Pro 
        195                 200                 205             


Ala Glu Lys Ala Val Glu Val Ile Gln Leu Asn Gly Pro Gly Val His 
    210                 215                 220                 


Thr Phe Thr Phe Pro Gln Thr Glu Phe Phe Ala Val Thr Ala Tyr Gln 
225                 230                 235                 240 


Asn Ile Gln Ile Thr Gln Leu Lys Ile Asp Tyr Asn Pro Phe Ala Lys 
                245                 250                 255     


Gly Phe Arg Asp Asp Gly Leu Asn Asn Lys Pro Gln Arg Asp Gly Lys 
            260                 265                 270         


Gln Lys Asn Ser Ser Asp Gln Glu Gly Asn Asn Ile Ser Ser Ser Ser 
        275                 280                 285             


Gly His Arg Val Arg Leu Thr Glu Gly Gln Gly Ser Glu Ile Gln Pro 
    290                 295                 300                 


Gly Asp Leu Asp Pro Leu Ser Arg Gly His Glu Thr Ser Gly Lys Gly 
305                 310                 315                 320 


Leu Glu Lys Thr Ser Leu Asn Ile Lys Arg Asp Phe Leu Gly Phe Met 
                325                 330                 335     


Asp Thr Asp Ser Ala Leu Ser Glu Val Pro Gln Leu Lys Gln Glu Ile 
            340                 345                 350         


Ser Glu Cys Leu Ile Ala Ser Ser Phe Glu Asp Asp Ser Arg Val Ala 
        355                 360                 365             


Ser Pro Leu Asp Gln Asn Gly Ser Phe Asn Val Val Ile Lys Glu Glu 
    370                 375                 380                 


Pro Leu Asp Asp Tyr Asp Tyr Glu Leu Gly Glu Cys Pro Glu Gly Val 
385                 390                 395                 400 


Thr Val Lys Gln Glu Glu Thr Asp Glu Glu Thr Asp Val Tyr Ser Asn 
                405                 410                 415     


Ser Asp Asp Asp Pro Ile Leu Glu Lys Gln Leu Lys Arg His Asn Lys 
            420                 425                 430         


Val Asp Asn Pro Glu Ala Asp His Leu Ser Ser Lys Trp Leu Pro Ser 
        435                 440                 445             


Ser Pro Ser Gly Val Ala Lys Ala Lys Met Phe Lys Leu Asp Thr Gly 
    450                 455                 460                 


Lys Met Pro Val Val Tyr Leu Glu Pro Cys Ala Val Thr Arg Ser Thr 
465                 470                 475                 480 


Val Lys Ile Ser Glu Leu Pro Asp Asn Met Leu Ser Thr Ser Arg Lys 
                485                 490                 495     


Asp Lys Ser Ser Met Leu Ala Glu Leu Glu Tyr Leu Pro Thr Tyr Ile 
            500                 505                 510         


Glu Asn Ser Asn Glu Thr Ala Phe Cys Leu Gly Lys Glu Ser Glu Asn 
        515                 520                 525             


Gly Leu Arg Lys His Ser Pro Asp Leu Arg Val Val Gln Lys Tyr Pro 
    530                 535                 540                 


Leu Leu Lys Glu Pro Gln Trp Lys Tyr Pro Asp Ile Ser Asp Ser Ile 
545                 550                 555                 560 


Ser Thr Glu Arg Ile Leu Asp Asp Ser Lys Asp Ser Val Gly Asp Ser 
                565                 570                 575     


Leu Ser Gly Lys Glu Asp Leu Gly Arg Lys Arg Thr Thr Met Leu Lys 
            580                 585                 590         


Ile Ala Thr Ala Ala Lys Val Val Asn Ala Asn Gln Asn Ala Ser Pro 
        595                 600                 605             


Asn Val Pro Gly Lys Arg Gly Arg Pro Arg Lys Leu Lys Leu Cys Lys 
    610                 615                 620                 


Ala Gly Arg Pro Pro Lys Asn Thr Gly Lys Ser Leu Ile Ser Thr Lys 
625                 630                 635                 640 


Asn Thr Pro Val Ser Pro Gly Ser Thr Phe Pro Asp Val Lys Pro Asp 
                645                 650                 655     


Leu Glu Asp Val Asp Gly Val Leu Phe Val Ser Phe Glu Ser Lys Glu 
            660                 665                 670         


Ala Leu Asp Ile His Ala Val Asp Gly Thr Thr Glu Glu Ser Ser Ser 
        675                 680                 685             


Leu Gln Ala Ser Thr Thr Asn Asp Ser Gly Tyr Arg Ala Arg Ile Ser 
    690                 695                 700                 


Gln Leu Glu Lys Glu Leu Ile Glu Asp Leu Lys Thr Leu Arg His Lys 
705                 710                 715                 720 


Gln Val Ile His Pro Gly Leu Gln Glu Val Gly Leu Lys Leu Asn Ser 
                725                 730                 735     


Val Asp Pro Thr Met Ser Ile Asp Leu Lys Tyr Leu Gly Val Gln Leu 
            740                 745                 750         


Pro Leu Ala Pro Ala Thr Ser Phe Pro Phe Trp Asn Leu Thr Gly Thr 
        755                 760                 765             


Asn Pro Ala Ser Pro Asp Ala Gly Phe Pro Phe Val Ser Arg Thr Gly 
    770                 775                 780                 


Lys Thr Asn Asp Phe Thr Lys Ile Lys Gly Trp Arg Gly Lys Phe His 
785                 790                 795                 800 


Ser Ala Ser Ala Ser Arg Asn Glu Gly Gly Asn Ser Glu Ser Ser Leu 
                805                 810                 815     


Lys Asn Arg Ser Ala Phe Cys Ser Asp Lys Leu Asp Glu Tyr Leu Glu 
            820                 825                 830         


Asn Glu Gly Lys Leu Met Glu Thr Ser Met Gly Phe Ser Ser Asn Ala 
        835                 840                 845             


Pro Thr Ser Pro Val Val Tyr Gln Leu Pro Thr Lys Ser Thr Ser Tyr 
    850                 855                 860                 


Val Arg Thr Leu Asp Ser Val Leu Lys Lys Gln Ser Thr Ile Ser Pro 
865                 870                 875                 880 


Ser Thr Ser Tyr Ser Leu Lys Pro His Ser Val Pro Pro Val Ser Arg 
                885                 890                 895     


Lys Ala Lys Ser Gln Asn Arg Gln Ala Thr Phe Ser Gly Arg Thr Lys 
            900                 905                 910         


Ser Ser Tyr Lys Ser Ile Leu Pro Tyr Pro Val Ser Pro Lys Gln Lys 
        915                 920                 925             


Tyr Ser His Val Ile Leu Gly Asp Lys Val Thr Lys Asn Ser Ser Gly 
    930                 935                 940                 


Ile Ile Ser Glu Asn Gln Ala Asn Asn Phe Val Val Pro Thr Leu Asp 
945                 950                 955                 960 


Glu Asn Ile Phe Pro Lys Gln Ile Ser Leu Arg Gln Ala Gln Gln Gln 
                965                 970                 975     


Gln Gln Gln Gln Gln Gly Ser Arg Pro Pro Gly Leu Ser Lys Ser Gln 
            980                 985                 990         


Val Lys Leu Met Asp Leu Glu Asp  Cys Ala Leu Trp Glu  Gly Lys Pro 
        995                 1000                 1005             


Arg Thr  Tyr Ile Thr Glu Glu  Arg Ala Asp Val Ser  Leu Thr Thr 
    1010                 1015                 1020             


Leu Leu  Thr Ala Gln Ala Ser  Leu Lys Thr Lys Pro  Ile His Thr 
    1025                 1030                 1035             


Ile Ile  Arg Lys Arg Ala Pro  Pro Cys Asn Asn Asp  Phe Cys Arg 
    1040                 1045                 1050             


Leu Gly  Cys Val Cys Ser Ser  Leu Ala Leu Glu Lys  Arg Gln Pro 
    1055                 1060                 1065             


Ala His  Cys Arg Arg Pro Asp  Cys Met Phe Gly Cys  Thr Cys Leu 
    1070                 1075                 1080             


Lys Arg  Lys Val Val Leu Val  Lys Gly Gly Ser Lys  Thr Lys His 
    1085                 1090                 1095             


Phe Gln  Arg Lys Ala Ala His  Arg Asp Pro Val Phe  Tyr Asp Thr 
    1100                 1105                 1110             


Leu Gly  Glu Glu Ala Arg Glu  Glu Glu Glu Gly Ile  Arg Glu Glu 
    1115                 1120                 1125             


Glu Glu  Gln Leu Lys Glu Lys  Lys Lys Arg Lys Lys  Leu Glu Tyr 
    1130                 1135                 1140             


Thr Ile  Cys Glu Thr Glu Pro  Glu Gln Pro Val Arg  His Tyr Pro 
    1145                 1150                 1155             


Leu Trp  Val Lys Val Glu Gly  Glu Val Asp Pro Glu  Pro Val Tyr 
    1160                 1165                 1170             


Ile Pro  Thr Pro Ser Val Ile  Glu Pro Met Lys Pro  Leu Leu Leu 
    1175                 1180                 1185             


Pro Gln  Pro Glu Val Leu Ser  Pro Thr Val Lys Gly  Lys Leu Leu 
    1190                 1195                 1200             


Thr Gly  Ile Lys Ser Pro Arg  Ser Tyr Thr Pro Lys  Pro Asn Pro 
    1205                 1210                 1215             


Val Ile  Arg Glu Glu Asp Lys  Asp Pro Val Tyr Leu  Tyr Phe Glu 
    1220                 1225                 1230             


Ser Met  Met Thr Cys Ala Arg  Val Arg Val Tyr Glu  Arg Lys Lys 
    1235                 1240                 1245             


Glu Asp  Gln Arg Gln Pro Ser  Ser Ser Ser Ser Pro  Ser Pro Ser 
    1250                 1255                 1260             


Phe Gln  Gln Gln Thr Ser Cys  His Ser Ser Pro Glu  Asn His Asn 
    1265                 1270                 1275             


Asn Ala  Lys Glu Pro Asp Ser  Glu Gln Gln Pro Leu  Lys Gln Leu 
    1280                 1285                 1290             


Thr Cys  Asp Leu Glu Asp Asp  Ser Asp Lys Leu Gln  Glu Lys Ser 
    1295                 1300                 1305             


Trp Lys  Ser Ser Cys Asn Glu  Gly Glu Ser Ser Ser  Thr Ser Tyr 
    1310                 1315                 1320             


Met His  Gln Arg Ser Pro Gly  Gly Pro Thr Lys Leu  Ile Glu Ile 
    1325                 1330                 1335             


Ile Ser  Asp Cys Asn Trp Glu  Glu Asp Arg Asn Lys  Ile Leu Ser 
    1340                 1345                 1350             


Ile Leu  Ser Gln His Ile Asn  Ser Asn Met Pro Gln  Ser Leu Lys 
    1355                 1360                 1365             


Val Gly  Ser Phe Ile Ile Glu  Leu Ala Ser Gln Arg  Lys Ser Arg 
    1370                 1375                 1380             


Gly Glu  Lys Asn Pro Pro Val  Tyr Ser Ser Arg Val  Lys Ile Ser 
    1385                 1390                 1395             


Met Pro  Ser Cys Gln Asp Gln  Asp Asp Met Ala Glu  Lys Ser Gly 
    1400                 1405                 1410             


Ser Glu  Thr Pro Asp Gly Pro  Leu Ser Pro Gly Lys  Met Glu Asp 
    1415                 1420                 1425             


Ile Ser  Pro Val Gln Thr Asp  Ala Leu Asp Ser Val  Arg Glu Arg 
    1430                 1435                 1440             


Leu His  Gly Gly Lys Gly Leu  Pro Phe Tyr Ala Gly  Leu Ser Pro 
    1445                 1450                 1455             


Ala Gly  Lys Leu Val Ala Tyr  Lys Arg Lys Pro Ser  Ser Ser Thr 
    1460                 1465                 1470             


Ser Gly  Leu Ile Gln Val Ala  Ser Asn Ala Lys Val  Ala Ala Ser 
    1475                 1480                 1485             


Arg Lys  Pro Arg Thr Leu Leu  Pro Ser Thr Ser Asn  Ser Lys Met 
    1490                 1495                 1500             


Ala Ser  Ser Ser Gly Thr Ala  Thr Asn Arg Pro Gly  Lys Asn Leu 
    1505                 1510                 1515             


Lys Ala  Phe Val Pro Ala Lys  Arg Pro Ile Ala Ala  Arg Pro Ser 
    1520                 1525                 1530             


Pro Gly  Gly Val Phe Thr Gln  Phe Val Met Ser Lys  Val Gly Ala 
    1535                 1540                 1545             


Leu Gln  Gln Lys Ile Pro Gly  Val Ser Thr Pro Gln  Thr Leu Ala 
    1550                 1555                 1560             


Gly Thr  Gln Lys Phe Ser Ile  Arg Pro Ser Pro Val  Met Val Val 
    1565                 1570                 1575             


Thr Pro  Val Val Ser Ser Glu  Pro Val Gln Val Cys  Ser Pro Val 
    1580                 1585                 1590             


Thr Ala  Ala Val Thr Thr Thr  Thr Pro Gln Val Phe  Leu Glu Asn 
    1595                 1600                 1605             


Thr Thr  Ala Val Thr Pro Met  Thr Ala Ile Ser Asp  Val Glu Thr 
    1610                 1615                 1620             


Lys Glu  Thr Thr Tyr Ser Ser  Gly Ala Thr Thr Thr  Gly Val Val 
    1625                 1630                 1635             


Glu Val  Ser Glu Thr Asn Thr  Ser Thr Ser Val Thr  Ser Thr Gln 
    1640                 1645                 1650             


Ser Thr  Ala Thr Val Asn Leu  Thr Lys Thr Thr Gly  Ile Thr Thr 
    1655                 1660                 1665             


Pro Val  Ala Ser Val Ala Phe  Pro Lys Ser Leu Val  Ala Ser Pro 
    1670                 1675                 1680             


Ser Thr  Ile Thr Leu Pro Val  Ala Ser Thr Ala Ser  Thr Ser Leu 
    1685                 1690                 1695             


Val Val  Val Thr Ala Ala Ala  Ser Ser Ser Met Val  Thr Thr Pro 
    1700                 1705                 1710             


Thr Ser  Ser Leu Gly Ser Val  Pro Ile Ile Leu Ser  Gly Ile Asn 
    1715                 1720                 1725             


Gly Ser  Pro Pro Val Ser Gln  Arg Pro Glu Asn Ala  Ala Gln Ile 
    1730                 1735                 1740             


Pro Val  Ala Thr Pro Gln Val  Ser Pro Asn Thr Val  Lys Arg Ala 
    1745                 1750                 1755             


Gly Pro  Arg Leu Leu Leu Ile  Pro Val Gln Gln Gly  Ser Pro Thr 
    1760                 1765                 1770             


Leu Arg  Pro Val Ser Asn Thr  Gln Leu Gln Gly His  Arg Met Val 
    1775                 1780                 1785             


Leu Gln  Pro Val Arg Ser Pro  Ser Gly Met Asn Leu  Phe Arg His 
    1790                 1795                 1800             


Pro Asn  Gly Gln Ile Val Gln  Leu Leu Pro Leu His  Gln Leu Arg 
    1805                 1810                 1815             


Gly Ser  Asn Thr Gln Pro Asn  Leu Gln Pro Val Met  Phe Arg Asn 
    1820                 1825                 1830             


Pro Gly  Ser Val Met Gly Ile  Arg Leu Pro Ala Pro  Ser Lys Pro 
    1835                 1840                 1845             


Ser Glu  Thr Pro Pro Ser Ser  Thr Ser Ser Ser Ala  Phe Ser Val 
    1850                 1855                 1860             


Met Asn  Pro Val Ile Gln Ala  Val Gly Ser Ser Ser  Ala Val Asn 
    1865                 1870                 1875             


Val Ile  Thr Gln Ala Pro Ser  Leu Leu Ser Ser Gly  Ala Ser Phe 
    1880                 1885                 1890             


Val Ser  Gln Ala Gly Thr Leu  Thr Leu Arg Ile Ser  Pro Pro Glu 
    1895                 1900                 1905             


Pro Gln  Ser Phe Ala Ser Lys  Thr Gly Ser Glu Thr  Lys Ile Thr 
    1910                 1915                 1920             


Tyr Ser  Ser Gly Gly Gln Pro  Val Gly Thr Ala Ser  Leu Ile Pro 
    1925                 1930                 1935             


Leu Gln  Ser Gly Ser Phe Ala  Leu Leu Gln Leu Pro  Gly Gln Lys 
    1940                 1945                 1950             


Pro Val  Pro Ser Ser Ile Leu  Gln His Val Ala Ser  Leu Gln Met 
    1955                 1960                 1965             


Lys Arg  Glu Ser Gln Asn Pro  Asp Gln Lys Asp Glu  Thr Asn Ser 
    1970                 1975                 1980             


Ile Lys  Arg Glu Gln Glu Thr  Lys Lys Val Leu Gln  Ser Glu Gly 
    1985                 1990                 1995             


Glu Ala  Val Asp Pro Glu Ala  Asn Val Ile Lys Gln  Asn Ser Gly 
    2000                 2005                 2010             


Ala Ala  Thr Ser Glu Glu Thr  Leu Asn Asp Ser Leu  Glu Asp Arg 
    2015                 2020                 2025             


Gly Asp  His Leu Asp Glu Glu  Cys Leu Pro Glu Glu  Gly Cys Ala 
    2030                 2035                 2040             


Thr Val  Lys Pro Ser Glu His  Ser Cys Ile Thr Gly  Ser His Thr 
    2045                 2050                 2055             


Asp Gln  Asp Tyr Lys Asp Val  Asn Glu Glu Tyr Gly  Ala Arg Asn 
    2060                 2065                 2070             


Arg Lys  Ser Ser Lys Glu Lys  Val Ala Val Leu Glu  Val Arg Thr 
    2075                 2080                 2085             


Ile Ser  Glu Lys Ala Ser Asn  Lys Thr Val Gln Asn  Leu Ser Lys 
    2090                 2095                 2100             


Val Gln  His Gln Lys Leu Gly  Asp Val Lys Val Glu  Gln Gln Lys 
    2105                 2110                 2115             


Gly Phe  Asp Asn Pro Glu Glu  Asn Ser Ser Glu Phe  Pro Val Thr 
    2120                 2125                 2130             


Phe Lys  Glu Glu Ser Lys Phe  Glu Leu Ser Gly Ser  Lys Val Met 
    2135                 2140                 2145             


Glu Gln  Gln Ser Asn Leu Gln  Pro Glu Ala Lys Glu  Lys Glu Cys 
    2150                 2155                 2160             


Gly Asp  Ser Leu Glu Lys Asp  Arg Glu Arg Trp Arg  Lys His Leu 
    2165                 2170                 2175             


Lys Gly  Pro Leu Thr Arg Lys  Cys Val Gly Ala Ser  Gln Glu Cys 
    2180                 2185                 2190             


Lys Lys  Glu Ala Asp Glu Gln  Leu Ile Lys Glu Thr  Lys Thr Cys 
    2195                 2200                 2205             


Gln Glu  Asn Ser Asp Val Phe  Gln Gln Glu Gln Gly  Ile Ser Asp 
    2210                 2215                 2220             


Leu Leu  Gly Lys Ser Gly Ile  Thr Glu Asp Ala Arg  Val Leu Lys 
    2225                 2230                 2235             


Thr Glu  Cys Asp Ser Trp Ser  Arg Ile Ser Asn Pro  Ser Ala Phe 
    2240                 2245                 2250             


Ser Ile  Val Pro Arg Arg Ala  Ala Lys Ser Ser Arg  Gly Asn Gly 
    2255                 2260                 2265             


His Phe  Gln Gly His Leu Leu  Leu Pro Gly Glu Gln  Ile Gln Pro 
    2270                 2275                 2280             


Lys Gln  Glu Lys Lys Gly Gly  Arg Ser Ser Ala Asp  Phe Thr Val 
    2285                 2290                 2295             


Leu Asp  Leu Glu Glu Asp Asp  Glu Asp Asp Asn Glu  Lys Thr Asp 
    2300                 2305                 2310             


Asp Ser  Ile Asp Glu Ile Val  Asp Val Val Ser Asp  Tyr Gln Ser 
    2315                 2320                 2325             


Glu Glu  Val Asp Asp Val Glu  Lys Asn Asn Cys Val  Glu Tyr Ile 
    2330                 2335                 2340             


Glu Asp  Asp Glu Glu His Val  Asp Ile Glu Thr Val  Glu Glu Leu 
    2345                 2350                 2355             


Ser Glu  Glu Ile Asn Val Ala  His Leu Lys Thr Thr  Ala Ala His 
    2360                 2365                 2370             


Thr Gln  Ser Phe Lys Gln Pro  Ser Cys Thr His Ile  Ser Ala Asp 
    2375                 2380                 2385             


Glu Lys  Ala Ala Glu Arg Ser  Arg Lys Ala Pro Pro  Ile Pro Leu 
    2390                 2395                 2400             


Lys Leu  Lys Pro Asp Tyr Trp  Ser Asp Lys Leu Gln  Lys Glu Ala 
    2405                 2410                 2415             


Glu Ala  Phe Ala Tyr Tyr Arg  Arg Thr His Thr Ala  Asn Glu Arg 
    2420                 2425                 2430             


Arg Arg  Arg Gly Glu Met Arg  Asp Leu Phe Glu Lys  Leu Lys Ile 
    2435                 2440                 2445             


Thr Leu  Gly Leu Leu His Ser  Ser Lys Val Ser Lys  Ser Leu Ile 
    2450                 2455                 2460             


Leu Thr  Arg Ala Phe Ser Glu  Ile Gln Gly Leu Thr  Asp Gln Ala 
    2465                 2470                 2475             


Asp Lys  Leu Ile Gly Gln Lys  Asn Leu Leu Thr Arg  Lys Arg Asn 
    2480                 2485                 2490             


Ile Leu  Ile Arg Lys Val Ser  Ser Leu Ser Gly Lys  Thr Glu Glu 
    2495                 2500                 2505             


Val Val  Leu Lys Lys Leu Glu  Tyr Ile Tyr Ala Lys  Gln Gln Ala 
    2510                 2515                 2520             


Leu Glu  Ala Gln Lys Arg Lys  Lys Lys Met Gly Ser  Asp Glu Phe 
    2525                 2530                 2535             


Asp Ile  Ser Pro Arg Ile Ser  Lys Gln Gln Glu Gly  Ser Ser Ala 
    2540                 2545                 2550             


Ser Ser  Val Asp Leu Gly Gln  Met Phe Ile Asn Asn  Arg Arg Gly 
    2555                 2560                 2565             


Lys Pro  Leu Ile Leu Ser Arg  Lys Lys Asp Gln Ala  Thr Glu Asn 
    2570                 2575                 2580             


Thr Ser  Pro Leu Asn Thr Pro  His Thr Ser Ala Asn  Leu Val Met 
    2585                 2590                 2595             


Thr Pro  Gln Gly Gln Leu Leu  Thr Leu Lys Gly Pro  Leu Phe Ser 
    2600                 2605                 2610             


Gly Pro  Val Val Ala Val Ser  Pro Asp Leu Leu Glu  Ser Asp Leu 
    2615                 2620                 2625             


Lys Pro  Gln Val Ala Gly Ser  Ala Val Ala Leu Pro  Glu Asn Asp 
    2630                 2635                 2640             


Asp Leu  Phe Met Met Pro Arg  Ile Val Asn Val Thr  Ser Leu Ala 
    2645                 2650                 2655             


Thr Glu  Gly Gly Leu Val Asp  Met Gly Gly Ser Lys  Tyr Pro His 
    2660                 2665                 2670             


Glu Val  Pro Asp Ser Lys Pro  Ser Asp His Leu Lys  Asp Thr Val 
    2675                 2680                 2685             


Arg Asn  Glu Asp Asn Ser Leu  Glu Asp Lys Gly Arg  Ile Ser Ser 
    2690                 2695                 2700             


Arg Gly  Asn Arg Asp Gly Arg  Val Thr Leu Gly Pro  Thr Gln Val 
    2705                 2710                 2715             


Phe Leu  Ala Asn Lys Asp Ser  Gly Tyr Pro Gln Ile  Val Asp Val 
    2720                 2725                 2730             


Ser Asn  Met Gln Lys Ala Gln  Glu Phe Leu Pro Lys  Lys Ile Ser 
    2735                 2740                 2745             


Gly Asp  Met Arg Gly Ile Gln  Tyr Lys Trp Lys Glu  Ser Glu Ser 
    2750                 2755                 2760             


Arg Gly  Glu Arg Val Lys Ser  Lys Asp Ser Ser Phe  His Lys Leu 
    2765                 2770                 2775             


Lys Met  Lys Asp Leu Lys Asp  Ser Ser Ile Glu Met  Glu Leu Arg 
    2780                 2785                 2790             


Lys Val  Thr Ser Ala Ile Glu  Glu Ala Ala Leu Asp  Ser Ser Glu 
    2795                 2800                 2805             


Leu Leu  Thr Asn Met Glu Asp  Glu Asp Asp Thr Asp  Glu Thr Leu 
    2810                 2815                 2820             


Thr Ser  Leu Leu Asn Glu Ile  Ala Phe Leu Asn Gln  Gln Leu Asn 
    2825                 2830                 2835             


Asp Asp  Ser Val Gly Leu Ala  Glu Leu Pro Ser Ser  Met Asp Thr 
    2840                 2845                 2850             


Glu Phe  Pro Gly Asp Ala Arg  Arg Ala Phe Ile Ser  Lys Val Pro 
    2855                 2860                 2865             


Pro Gly  Ser Arg Ala Thr Phe  Gln Val Glu His Leu  Gly Thr Gly 
    2870                 2875                 2880             


Leu Lys  Glu Leu Pro Asp Val  Gln Gly Glu Ser Asp  Ser Ile Ser 
    2885                 2890                 2895             


Pro Leu  Leu Leu His Leu Glu  Asp Asp Asp Phe Ser  Glu Asn Glu 
    2900                 2905                 2910             


Lys Gln  Leu Ala Glu Pro Ala  Ser Glu Pro Asp Val  Leu Lys Ile 
    2915                 2920                 2925             


Val Ile  Asp Ser Glu Ile Lys  Asp Ser Leu Leu Ser  Asn Lys Lys 
    2930                 2935                 2940             


Ala Ile  Asp Gly Gly Lys Asn  Thr Ser Gly Leu Pro  Ala Glu Pro 
    2945                 2950                 2955             


Glu Ser  Val Ser Ser Pro Pro  Thr Leu His Met Lys  Thr Gly Leu 
    2960                 2965                 2970             


Glu Asn  Ser Asn Ser Thr Asp  Thr Leu Trp Arg Pro  Met Pro Lys 
    2975                 2980                 2985             


Leu Ala  Pro Leu Gly Leu Lys  Val Ala Asn Pro Ser  Ser Asp Ala 
    2990                 2995                 3000             


Asp Gly  Gln Ser Leu Lys Val  Met Pro Cys Leu Ala  Pro Ile Ala 
    3005                 3010                 3015             


Ala Lys  Val Gly Ser Val Gly  His Lys Met Asn Leu  Thr Gly Asn 
    3020                 3025                 3030             


Asp Gln  Glu Gly Arg Glu Ser  Lys Val Met Pro Thr  Leu Ala Pro 
    3035                 3040                 3045             


Val Val  Ala Lys Leu Gly Asn  Ser Gly Ala Ser Pro  Ser Ser Ala 
    3050                 3055                 3060             


Gly Lys  
    3065 


<210>  8652
<211>  1086
<212>  PRT
<213>  Homo Sapiens

<400>  8652

Met Glu Glu Lys Gln Gln Ile Ile Leu Ala Asn Gln Asp Gly Gly Thr 
1               5                   10                  15      


Val Ala Gly Ala Ala Pro Thr Phe Phe Val Ile Leu Lys Gln Pro Gly 
            20                  25                  30          


Asn Gly Lys Thr Asp Gln Gly Ile Leu Val Thr Asn Gln Asp Ala Cys 
        35                  40                  45              


Ala Leu Ala Ser Ser Val Ser Ser Pro Val Lys Ser Lys Gly Lys Ile 
    50                  55                  60                  


Cys Leu Pro Ala Asp Cys Thr Val Gly Gly Ile Thr Val Thr Leu Asp 
65                  70                  75                  80  


Asn Asn Ser Met Trp Asn Glu Phe Tyr His Arg Ser Thr Glu Met Ile 
                85                  90                  95      


Leu Thr Lys Gln Gly Arg Arg Met Phe Pro Tyr Cys Arg Tyr Trp Ile 
            100                 105                 110         


Thr Gly Leu Asp Ser Asn Leu Lys Tyr Ile Leu Val Met Asp Ile Ser 
        115                 120                 125             


Pro Val Asp Asn His Arg Tyr Lys Trp Asn Gly Arg Trp Trp Glu Pro 
    130                 135                 140                 


Ser Gly Lys Ala Glu Pro His Val Leu Gly Arg Val Phe Ile His Pro 
145                 150                 155                 160 


Glu Ser Pro Ser Thr Gly His Tyr Trp Met His Gln Pro Val Ser Phe 
                165                 170                 175     


Tyr Lys Leu Lys Leu Thr Asn Asn Thr Leu Asp Gln Glu Gly His Ile 
            180                 185                 190         


Ile Leu His Ser Met His Arg Tyr Leu Pro Arg Leu His Leu Val Pro 
        195                 200                 205             


Ala Glu Lys Ala Val Glu Val Ile Gln Leu Asn Gly Pro Gly Val His 
    210                 215                 220                 


Thr Phe Thr Phe Pro Gln Thr Glu Phe Phe Ala Val Thr Ala Tyr Gln 
225                 230                 235                 240 


Asn Ile Gln Ile Thr Gln Leu Lys Ile Asp Tyr Asn Pro Phe Ala Lys 
                245                 250                 255     


Gly Phe Arg Asp Asp Gly Leu Asn Asn Lys Pro Gln Arg Asp Gly Lys 
            260                 265                 270         


Gln Lys Asn Ser Ser Asp Gln Glu Gly Asn Asn Ile Ser Ser Ser Ser 
        275                 280                 285             


Gly His Arg Val Arg Leu Thr Glu Gly Gln Gly Ser Glu Ile Gln Pro 
    290                 295                 300                 


Gly Asp Leu Asp Pro Leu Ser Arg Gly His Glu Thr Ser Gly Lys Gly 
305                 310                 315                 320 


Leu Glu Lys Thr Ser Leu Asn Ile Lys Arg Asp Phe Leu Gly Phe Met 
                325                 330                 335     


Asp Thr Asp Ser Ala Leu Ser Glu Val Pro Gln Leu Lys Gln Glu Ile 
            340                 345                 350         


Ser Glu Cys Leu Ile Ala Ser Ser Phe Glu Asp Asp Ser Arg Val Ala 
        355                 360                 365             


Ser Pro Leu Asp Gln Asn Gly Ser Phe Asn Val Val Ile Lys Glu Glu 
    370                 375                 380                 


Pro Leu Asp Asp Tyr Asp Tyr Glu Leu Gly Glu Cys Pro Glu Gly Val 
385                 390                 395                 400 


Thr Val Lys Gln Glu Glu Thr Asp Glu Glu Thr Asp Val Tyr Ser Asn 
                405                 410                 415     


Ser Asp Asp Asp Pro Ile Leu Glu Lys Gln Leu Lys Arg His Asn Lys 
            420                 425                 430         


Val Asp Asn Pro Glu Ala Asp His Leu Ser Ser Lys Trp Leu Pro Ser 
        435                 440                 445             


Ser Pro Ser Gly Val Ala Lys Ala Lys Met Phe Lys Leu Asp Thr Gly 
    450                 455                 460                 


Lys Met Pro Val Val Tyr Leu Glu Pro Cys Ala Val Thr Arg Ser Thr 
465                 470                 475                 480 


Val Lys Ile Ser Glu Leu Pro Asp Asn Met Leu Ser Thr Ser Arg Lys 
                485                 490                 495     


Asp Lys Ser Ser Met Leu Ala Glu Leu Glu Tyr Leu Pro Thr Tyr Ile 
            500                 505                 510         


Glu Asn Ser Asn Glu Thr Ala Phe Cys Leu Gly Lys Glu Ser Glu Asn 
        515                 520                 525             


Gly Leu Arg Lys His Ser Pro Asp Leu Arg Val Val Gln Lys Tyr Pro 
    530                 535                 540                 


Leu Leu Lys Glu Pro Gln Trp Lys Tyr Pro Asp Ile Ser Asp Ser Ile 
545                 550                 555                 560 


Ser Thr Glu Arg Ile Leu Asp Asp Ser Lys Asp Ser Val Gly Asp Ser 
                565                 570                 575     


Leu Ser Gly Lys Glu Asp Leu Gly Arg Lys Arg Thr Thr Met Leu Lys 
            580                 585                 590         


Ile Ala Thr Ala Ala Lys Val Val Asn Ala Asn Gln Asn Ala Ser Pro 
        595                 600                 605             


Asn Val Pro Gly Lys Arg Gly Arg Pro Arg Lys Leu Lys Leu Cys Lys 
    610                 615                 620                 


Ala Gly Arg Pro Pro Lys Asn Thr Gly Lys Ser Leu Ile Ser Thr Lys 
625                 630                 635                 640 


Asn Thr Pro Val Ser Pro Gly Ser Thr Phe Pro Asp Val Lys Pro Asp 
                645                 650                 655     


Leu Glu Asp Val Asp Gly Val Leu Phe Val Ser Phe Glu Ser Lys Glu 
            660                 665                 670         


Ala Leu Asp Ile His Ala Val Asp Gly Thr Thr Glu Glu Ser Ser Ser 
        675                 680                 685             


Leu Gln Ala Ser Thr Thr Asn Asp Ser Gly Tyr Arg Ala Arg Ile Ser 
    690                 695                 700                 


Gln Leu Glu Lys Glu Leu Ile Glu Asp Leu Lys Thr Leu Arg His Lys 
705                 710                 715                 720 


Gln Val Ile His Pro Gly Leu Gln Glu Val Gly Leu Lys Leu Asn Ser 
                725                 730                 735     


Val Asp Pro Thr Met Ser Ile Asp Leu Lys Tyr Leu Gly Val Gln Leu 
            740                 745                 750         


Pro Leu Ala Pro Ala Thr Ser Phe Pro Phe Trp Asn Leu Thr Gly Thr 
        755                 760                 765             


Asn Pro Ala Ser Pro Asp Ala Gly Phe Pro Phe Val Ser Arg Thr Gly 
    770                 775                 780                 


Lys Thr Asn Asp Phe Thr Lys Ile Lys Gly Trp Arg Gly Lys Phe His 
785                 790                 795                 800 


Ser Ala Ser Ala Ser Arg Asn Glu Gly Gly Asn Ser Glu Ser Ser Leu 
                805                 810                 815     


Lys Asn Arg Ser Ala Phe Cys Ser Asp Lys Leu Asp Glu Tyr Leu Glu 
            820                 825                 830         


Asn Glu Gly Lys Leu Met Glu Thr Ser Met Gly Phe Ser Ser Asn Ala 
        835                 840                 845             


Pro Thr Ser Pro Val Val Tyr Gln Leu Pro Thr Lys Ser Thr Ser Tyr 
    850                 855                 860                 


Val Arg Thr Leu Asp Ser Val Leu Lys Lys Gln Ser Thr Ile Ser Pro 
865                 870                 875                 880 


Ser Thr Ser Tyr Ser Leu Lys Pro His Ser Val Pro Pro Val Ser Arg 
                885                 890                 895     


Lys Ala Lys Ser Gln Asn Arg Gln Ala Thr Phe Ser Gly Arg Thr Lys 
            900                 905                 910         


Ser Ser Tyr Lys Ser Ile Leu Pro Tyr Pro Val Ser Pro Lys Gln Lys 
        915                 920                 925             


Tyr Ser His Val Ile Leu Gly Asp Lys Val Thr Lys Asn Ser Ser Gly 
    930                 935                 940                 


Ile Ile Ser Glu Asn Gln Ala Asn Asn Phe Val Val Pro Thr Leu Asp 
945                 950                 955                 960 


Glu Asn Ile Phe Pro Lys Gln Ile Ser Leu Arg Gln Ala Gln Gln Gln 
                965                 970                 975     


Gln Gln Gln Gln Gln Gly Ser Arg Pro Pro Gly Leu Ser Lys Ser Gln 
            980                 985                 990         


Val Lys Leu Met Asp Leu Glu Asp  Cys Ala Leu Trp Glu  Gly Lys Pro 
        995                 1000                 1005             


Arg Thr  Tyr Ile Thr Glu Glu  Arg Ala Asp Val Ser  Leu Thr Thr 
    1010                 1015                 1020             


Leu Leu  Thr Ala Gln Ala Ser  Leu Lys Thr Lys Pro  Ile His Thr 
    1025                 1030                 1035             


Ile Ile  Arg Lys Arg Ala Pro  Pro Cys Asn Asn Asp  Phe Cys Arg 
    1040                 1045                 1050             


Leu Gly  Cys Val Cys Ser Ser  Leu Ala Leu Glu Lys  Arg Gln Pro 
    1055                 1060                 1065             


Ala His  Cys Arg Arg Pro Asp  Cys Met Phe Gly Cys  Thr Cys Leu 
    1070                 1075                 1080             


Lys Arg  Lys 
    1085     


<210>  8653
<211>  1138
<212>  PRT
<213>  Homo Sapiens

<400>  8653

Met Glu Glu Lys Gln Gln Ile Ile Leu Ala Asn Gln Asp Gly Gly Thr 
1               5                   10                  15      


Val Ala Gly Ala Ala Pro Thr Phe Phe Val Ile Leu Lys Gln Pro Gly 
            20                  25                  30          


Asn Gly Lys Thr Asp Gln Gly Ile Leu Val Thr Asn Gln Asp Ala Cys 
        35                  40                  45              


Ala Leu Ala Ser Ser Val Ser Ser Pro Val Lys Ser Lys Gly Lys Ile 
    50                  55                  60                  


Cys Leu Pro Ala Asp Cys Thr Val Gly Gly Ile Thr Val Thr Leu Asp 
65                  70                  75                  80  


Asn Asn Ser Met Trp Asn Glu Phe Tyr His Arg Ser Thr Glu Met Ile 
                85                  90                  95      


Leu Thr Lys Gln Gly Arg Arg Met Phe Pro Tyr Cys Arg Tyr Trp Ile 
            100                 105                 110         


Thr Gly Leu Asp Ser Asn Leu Lys Tyr Ile Leu Val Met Asp Ile Ser 
        115                 120                 125             


Pro Val Asp Asn His Arg Tyr Lys Trp Asn Gly Arg Trp Trp Glu Pro 
    130                 135                 140                 


Ser Gly Lys Ala Glu Pro His Val Leu Gly Arg Val Phe Ile His Pro 
145                 150                 155                 160 


Glu Ser Pro Ser Thr Gly His Tyr Trp Met His Gln Pro Val Ser Phe 
                165                 170                 175     


Tyr Lys Leu Lys Leu Thr Asn Asn Thr Leu Asp Gln Glu Gly His Ile 
            180                 185                 190         


Ile Leu His Ser Met His Arg Tyr Leu Pro Arg Leu His Leu Val Pro 
        195                 200                 205             


Ala Glu Lys Ala Val Glu Val Ile Gln Leu Asn Gly Pro Gly Val His 
    210                 215                 220                 


Thr Phe Thr Phe Pro Gln Thr Glu Phe Phe Ala Val Thr Ala Tyr Gln 
225                 230                 235                 240 


Asn Ile Gln Ile Thr Gln Leu Lys Ile Asp Tyr Asn Pro Phe Ala Lys 
                245                 250                 255     


Gly Phe Arg Asp Asp Gly Leu Asn Asn Lys Pro Gln Arg Asp Gly Lys 
            260                 265                 270         


Gln Lys Asn Ser Ser Asp Gln Glu Gly Asn Asn Ile Ser Ser Ser Ser 
        275                 280                 285             


Gly His Arg Val Arg Leu Thr Glu Gly Gln Gly Ser Glu Ile Gln Pro 
    290                 295                 300                 


Gly Asp Leu Asp Pro Leu Ser Arg Gly His Glu Thr Ser Gly Lys Gly 
305                 310                 315                 320 


Leu Glu Lys Thr Ser Leu Asn Ile Lys Arg Asp Phe Leu Gly Phe Met 
                325                 330                 335     


Asp Thr Asp Ser Ala Leu Ser Glu Val Pro Gln Leu Lys Gln Glu Ile 
            340                 345                 350         


Ser Glu Cys Leu Ile Ala Ser Ser Phe Glu Asp Asp Ser Arg Val Ala 
        355                 360                 365             


Ser Pro Leu Asp Gln Asn Gly Ser Phe Asn Val Val Ile Lys Glu Glu 
    370                 375                 380                 


Pro Leu Asp Asp Tyr Asp Tyr Glu Leu Gly Glu Cys Pro Glu Gly Val 
385                 390                 395                 400 


Thr Val Lys Gln Glu Glu Thr Asp Glu Glu Thr Asp Val Tyr Ser Asn 
                405                 410                 415     


Ser Asp Asp Asp Pro Ile Leu Glu Lys Gln Leu Lys Arg His Asn Lys 
            420                 425                 430         


Val Asp Asn Pro Glu Ala Asp His Leu Ser Ser Lys Trp Leu Pro Ser 
        435                 440                 445             


Ser Pro Ser Gly Val Ala Lys Ala Lys Met Phe Lys Leu Asp Thr Gly 
    450                 455                 460                 


Lys Met Pro Val Val Tyr Leu Glu Pro Cys Ala Val Thr Arg Ser Thr 
465                 470                 475                 480 


Val Lys Ile Ser Glu Leu Pro Asp Asn Met Leu Ser Thr Ser Arg Lys 
                485                 490                 495     


Asp Lys Ser Ser Met Leu Ala Glu Leu Glu Tyr Leu Pro Thr Tyr Ile 
            500                 505                 510         


Glu Asn Ser Asn Glu Thr Ala Phe Cys Leu Gly Lys Glu Ser Glu Asn 
        515                 520                 525             


Gly Leu Arg Lys His Ser Pro Asp Leu Arg Val Val Gln Lys Tyr Pro 
    530                 535                 540                 


Leu Leu Lys Glu Pro Gln Trp Lys Tyr Pro Asp Ile Ser Asp Ser Ile 
545                 550                 555                 560 


Ser Thr Glu Arg Ile Leu Asp Asp Ser Lys Asp Ser Val Gly Asp Ser 
                565                 570                 575     


Leu Ser Gly Lys Glu Asp Leu Gly Arg Lys Arg Thr Thr Met Leu Lys 
            580                 585                 590         


Ile Ala Thr Ala Ala Lys Val Val Asn Ala Asn Gln Asn Ala Ser Pro 
        595                 600                 605             


Asn Val Pro Gly Lys Arg Gly Arg Pro Arg Lys Leu Lys Leu Cys Lys 
    610                 615                 620                 


Ala Gly Arg Pro Pro Lys Asn Thr Gly Lys Ser Leu Ile Ser Thr Lys 
625                 630                 635                 640 


Asn Thr Pro Val Ser Pro Gly Ser Thr Phe Pro Asp Val Lys Pro Asp 
                645                 650                 655     


Leu Glu Asp Val Asp Gly Val Leu Phe Val Ser Phe Glu Ser Lys Glu 
            660                 665                 670         


Ala Leu Asp Ile His Ala Val Asp Gly Thr Thr Glu Glu Ser Ser Ser 
        675                 680                 685             


Leu Gln Ala Ser Thr Thr Asn Asp Ser Gly Tyr Arg Ala Arg Ile Ser 
    690                 695                 700                 


Gln Leu Glu Lys Glu Leu Ile Glu Asp Leu Lys Thr Leu Arg His Lys 
705                 710                 715                 720 


Gln Val Ile His Pro Gly Leu Gln Glu Val Gly Leu Lys Leu Asn Ser 
                725                 730                 735     


Val Asp Pro Thr Met Ser Ile Asp Leu Lys Tyr Leu Gly Val Gln Leu 
            740                 745                 750         


Pro Leu Ala Pro Ala Thr Ser Phe Pro Phe Trp Asn Leu Thr Gly Thr 
        755                 760                 765             


Asn Pro Ala Ser Pro Asp Ala Gly Phe Pro Phe Val Ser Arg Thr Gly 
    770                 775                 780                 


Lys Thr Asn Asp Phe Thr Lys Ile Lys Gly Trp Arg Gly Lys Phe His 
785                 790                 795                 800 


Ser Ala Ser Ala Ser Arg Asn Glu Gly Gly Asn Ser Glu Ser Ser Leu 
                805                 810                 815     


Lys Asn Arg Ser Ala Phe Cys Ser Asp Lys Leu Asp Glu Tyr Leu Glu 
            820                 825                 830         


Asn Glu Gly Lys Leu Met Glu Thr Ser Met Gly Phe Ser Ser Asn Ala 
        835                 840                 845             


Pro Thr Ser Pro Val Val Tyr Gln Leu Pro Thr Lys Ser Thr Ser Tyr 
    850                 855                 860                 


Val Arg Thr Leu Asp Ser Val Leu Lys Lys Gln Ser Thr Ile Ser Pro 
865                 870                 875                 880 


Ser Thr Ser Tyr Ser Leu Lys Pro His Ser Val Pro Pro Val Ser Arg 
                885                 890                 895     


Lys Ala Lys Ser Gln Asn Arg Gln Ala Thr Phe Ser Gly Arg Thr Lys 
            900                 905                 910         


Ser Ser Tyr Lys Ser Ile Leu Pro Tyr Pro Val Ser Pro Lys Gln Lys 
        915                 920                 925             


Tyr Ser His Val Ile Leu Gly Asp Lys Val Thr Lys Asn Ser Ser Gly 
    930                 935                 940                 


Ile Ile Ser Glu Asn Gln Ala Asn Asn Phe Val Val Pro Thr Leu Asp 
945                 950                 955                 960 


Glu Asn Ile Phe Pro Lys Gln Ile Ser Leu Arg Gln Ala Gln Gln Gln 
                965                 970                 975     


Gln Gln Gln Gln Gln Gly Ser Arg Pro Pro Gly Leu Ser Lys Ser Gln 
            980                 985                 990         


Val Lys Leu Met Asp Leu Glu Asp  Cys Ala Leu Trp Glu  Gly Lys Pro 
        995                 1000                 1005             


Arg Thr  Tyr Ile Thr Glu Glu  Arg Ala Asp Val Ser  Leu Thr Thr 
    1010                 1015                 1020             


Leu Leu  Thr Ala Gln Ala Ser  Leu Lys Thr Lys Pro  Ile His Thr 
    1025                 1030                 1035             


Ile Ile  Arg Lys Arg Ala Pro  Pro Cys Asn Asn Asp  Phe Cys Arg 
    1040                 1045                 1050             


Leu Gly  Cys Val Cys Ser Ser  Leu Ala Leu Glu Lys  Arg Gln Pro 
    1055                 1060                 1065             


Ala His  Cys Arg Arg Pro Asp  Cys Met Phe Gly Cys  Thr Cys Leu 
    1070                 1075                 1080             


Lys Arg  Lys Val Val Leu Val  Lys Gly Gly Ser Lys  Thr Lys His 
    1085                 1090                 1095             


Phe Gln  Arg Lys Ala Ala His  Arg Asp Pro Val Phe  Tyr Asp Thr 
    1100                 1105                 1110             


Leu Gly  Glu Glu Ala Arg Glu  Glu Glu Glu Gly Ile  Arg Glu Glu 
    1115                 1120                 1125             


Glu Glu  Gln Leu Lys Glu Lys  Lys Lys Arg 
    1130                 1135             


<210>  8654
<211>  2856
<212>  PRT
<213>  Homo Sapiens

<400>  8654

Met Glu Glu Lys Gln Gln Ile Ile Leu Ala Asn Gln Asp Gly Gly Thr 
1               5                   10                  15      


Val Ala Gly Ala Ala Pro Thr Phe Phe Val Ile Leu Lys Gln Pro Gly 
            20                  25                  30          


Asn Gly Lys Thr Asp Gln Gly Ile Leu Val Thr Asn Gln Asp Ala Cys 
        35                  40                  45              


Ala Leu Ala Ser Ser Val Ser Ser Pro Val Lys Ser Lys Gly Lys Ile 
    50                  55                  60                  


Cys Leu Pro Ala Asp Cys Thr Val Gly Gly Ile Thr Val Thr Leu Asp 
65                  70                  75                  80  


Asn Asn Ser Met Trp Asn Glu Phe Tyr His Arg Ser Thr Glu Met Ile 
                85                  90                  95      


Leu Thr Lys Gln Gly Arg Arg Met Phe Pro Tyr Cys Arg Tyr Trp Ile 
            100                 105                 110         


Thr Gly Leu Asp Ser Asn Leu Lys Tyr Ile Leu Val Met Asp Ile Ser 
        115                 120                 125             


Pro Val Asp Asn His Arg Tyr Lys Trp Asn Gly Arg Trp Trp Glu Pro 
    130                 135                 140                 


Ser Gly Lys Ala Glu Pro His Val Leu Gly Arg Val Phe Ile His Pro 
145                 150                 155                 160 


Glu Ser Pro Ser Thr Gly His Tyr Trp Met His Gln Pro Val Ser Phe 
                165                 170                 175     


Tyr Lys Leu Lys Leu Thr Asn Asn Thr Leu Asp Gln Glu Gly His Ile 
            180                 185                 190         


Ile Leu His Ser Met His Arg Tyr Leu Pro Arg Leu His Leu Val Pro 
        195                 200                 205             


Ala Glu Lys Ala Val Glu Val Ile Gln Leu Asn Gly Pro Gly Val His 
    210                 215                 220                 


Thr Phe Thr Phe Pro Gln Thr Glu Phe Phe Ala Val Thr Ala Tyr Gln 
225                 230                 235                 240 


Asn Ile Gln Ile Thr Gln Leu Lys Ile Asp Tyr Asn Pro Phe Ala Lys 
                245                 250                 255     


Gly Phe Arg Asp Asp Gly Leu Asn Asn Lys Pro Gln Arg Asp Gly Lys 
            260                 265                 270         


Gln Lys Asn Ser Ser Asp Gln Glu Gly Asn Asn Ile Ser Ser Ser Ser 
        275                 280                 285             


Gly His Arg Val Arg Leu Thr Glu Gly Gln Gly Ser Glu Ile Gln Pro 
    290                 295                 300                 


Gly Asp Leu Asp Pro Leu Ser Arg Gly His Glu Thr Ser Gly Lys Gly 
305                 310                 315                 320 


Leu Glu Lys Thr Ser Leu Asn Ile Lys Arg Asp Phe Leu Gly Phe Met 
                325                 330                 335     


Asp Thr Asp Ser Ala Leu Ser Glu Val Pro Gln Leu Lys Gln Glu Ile 
            340                 345                 350         


Ser Glu Cys Leu Ile Ala Ser Ser Phe Glu Asp Asp Ser Arg Val Ala 
        355                 360                 365             


Ser Pro Leu Asp Gln Asn Gly Ser Phe Asn Val Val Ile Lys Glu Glu 
    370                 375                 380                 


Pro Leu Asp Asp Tyr Asp Tyr Glu Leu Gly Glu Cys Pro Glu Gly Val 
385                 390                 395                 400 


Thr Val Lys Gln Glu Glu Thr Asp Glu Glu Thr Asp Val Tyr Ser Asn 
                405                 410                 415     


Ser Asp Asp Asp Pro Ile Leu Glu Lys Gln Leu Lys Arg His Asn Lys 
            420                 425                 430         


Val Asp Asn Pro Glu Ala Asp His Leu Ser Ser Lys Trp Leu Pro Ser 
        435                 440                 445             


Ser Pro Ser Gly Val Ala Lys Ala Lys Met Phe Lys Leu Asp Thr Gly 
    450                 455                 460                 


Lys Met Pro Val Val Tyr Leu Glu Pro Cys Ala Val Thr Arg Ser Thr 
465                 470                 475                 480 


Val Lys Ile Ser Glu Leu Pro Asp Asn Met Leu Ser Thr Ser Arg Lys 
                485                 490                 495     


Asp Lys Ser Ser Met Leu Ala Glu Leu Glu Tyr Leu Pro Thr Tyr Ile 
            500                 505                 510         


Glu Asn Ser Asn Glu Thr Ala Phe Cys Leu Gly Lys Glu Ser Glu Asn 
        515                 520                 525             


Gly Leu Arg Lys His Ser Pro Asp Leu Arg Val Val Gln Lys Tyr Pro 
    530                 535                 540                 


Leu Leu Lys Glu Pro Gln Trp Lys Tyr Pro Asp Ile Ser Asp Ser Ile 
545                 550                 555                 560 


Ser Thr Glu Arg Ile Leu Asp Asp Ser Lys Asp Ser Val Gly Asp Ser 
                565                 570                 575     


Leu Ser Gly Lys Glu Asp Leu Gly Arg Lys Arg Thr Thr Met Leu Lys 
            580                 585                 590         


Ile Ala Thr Ala Ala Lys Val Val Asn Ala Asn Gln Asn Ala Ser Pro 
        595                 600                 605             


Asn Val Pro Gly Lys Arg Gly Arg Pro Arg Lys Leu Lys Leu Cys Lys 
    610                 615                 620                 


Ala Gly Arg Pro Pro Lys Asn Thr Gly Lys Ser Leu Ile Ser Thr Lys 
625                 630                 635                 640 


Asn Thr Pro Val Ser Pro Gly Ser Thr Phe Pro Asp Val Lys Pro Asp 
                645                 650                 655     


Leu Glu Asp Val Asp Gly Val Leu Phe Val Ser Phe Glu Ser Lys Glu 
            660                 665                 670         


Ala Leu Asp Ile His Ala Val Asp Gly Thr Thr Glu Glu Ser Ser Ser 
        675                 680                 685             


Leu Gln Ala Ser Thr Thr Asn Asp Ser Gly Tyr Arg Ala Arg Ile Ser 
    690                 695                 700                 


Gln Leu Glu Lys Glu Leu Ile Glu Asp Leu Lys Thr Leu Arg His Lys 
705                 710                 715                 720 


Gln Val Ile His Pro Gly Leu Gln Glu Val Gly Leu Lys Leu Asn Ser 
                725                 730                 735     


Val Asp Pro Thr Met Ser Ile Asp Leu Lys Tyr Leu Gly Val Gln Leu 
            740                 745                 750         


Pro Leu Ala Pro Ala Thr Ser Phe Pro Phe Trp Asn Leu Thr Gly Thr 
        755                 760                 765             


Asn Pro Ala Ser Pro Asp Ala Gly Phe Pro Phe Val Ser Arg Thr Gly 
    770                 775                 780                 


Lys Thr Asn Asp Phe Thr Lys Ile Lys Gly Trp Arg Gly Lys Phe His 
785                 790                 795                 800 


Ser Ala Ser Ala Ser Arg Asn Glu Gly Gly Asn Ser Glu Ser Ser Leu 
                805                 810                 815     


Lys Asn Arg Ser Ala Phe Cys Ser Asp Lys Leu Asp Glu Tyr Leu Glu 
            820                 825                 830         


Asn Glu Gly Lys Leu Met Glu Thr Ser Met Gly Phe Ser Ser Asn Ala 
        835                 840                 845             


Pro Thr Ser Pro Val Val Tyr Gln Leu Pro Thr Lys Ser Thr Ser Tyr 
    850                 855                 860                 


Val Arg Thr Leu Asp Ser Val Leu Lys Lys Gln Ser Thr Ile Ser Pro 
865                 870                 875                 880 


Ser Thr Ser Tyr Ser Leu Lys Pro His Ser Val Pro Pro Val Ser Arg 
                885                 890                 895     


Lys Ala Lys Ser Gln Asn Arg Gln Ala Thr Phe Ser Gly Arg Thr Lys 
            900                 905                 910         


Ser Ser Tyr Lys Ser Ile Leu Pro Tyr Pro Val Ser Pro Lys Gln Lys 
        915                 920                 925             


Tyr Ser His Val Ile Leu Gly Asp Lys Val Thr Lys Asn Ser Ser Gly 
    930                 935                 940                 


Ile Ile Ser Glu Asn Gln Ala Asn Asn Phe Val Val Pro Thr Leu Asp 
945                 950                 955                 960 


Glu Asn Ile Phe Pro Lys Gln Ile Ser Leu Arg Gln Ala Gln Gln Gln 
                965                 970                 975     


Gln Gln Gln Gln Gln Gly Ser Arg Pro Pro Gly Leu Ser Lys Ser Gln 
            980                 985                 990         


Val Lys Leu Met Asp Leu Glu Asp  Cys Ala Leu Trp Glu  Gly Lys Pro 
        995                 1000                 1005             


Arg Thr  Tyr Ile Thr Glu Glu  Arg Ala Asp Val Ser  Leu Thr Thr 
    1010                 1015                 1020             


Leu Leu  Thr Ala Gln Ala Ser  Leu Lys Thr Lys Pro  Ile His Thr 
    1025                 1030                 1035             


Ile Ile  Arg Lys Arg Ala Pro  Pro Cys Asn Asn Asp  Phe Cys Arg 
    1040                 1045                 1050             


Leu Gly  Cys Val Cys Ser Ser  Leu Ala Leu Glu Lys  Arg Gln Pro 
    1055                 1060                 1065             


Ala His  Cys Arg Arg Pro Asp  Cys Met Phe Gly Cys  Thr Cys Leu 
    1070                 1075                 1080             


Lys Arg  Lys Val Val Leu Val  Lys Gly Gly Ser Lys  Thr Lys His 
    1085                 1090                 1095             


Phe Gln  Arg Lys Ala Ala His  Arg Asp Pro Val Phe  Tyr Asp Thr 
    1100                 1105                 1110             


Leu Gly  Glu Glu Ala Arg Glu  Glu Glu Glu Gly Ile  Arg Glu Glu 
    1115                 1120                 1125             


Glu Glu  Gln Leu Lys Glu Lys  Lys Lys Arg Lys Lys  Leu Glu Tyr 
    1130                 1135                 1140             


Thr Ile  Cys Glu Thr Glu Pro  Glu Gln Pro Val Arg  His Tyr Pro 
    1145                 1150                 1155             


Leu Trp  Val Lys Val Glu Gly  Glu Val Asp Pro Glu  Pro Val Tyr 
    1160                 1165                 1170             


Ile Pro  Thr Pro Ser Val Ile  Glu Pro Met Lys Pro  Leu Leu Leu 
    1175                 1180                 1185             


Pro Gln  Pro Glu Val Leu Ser  Pro Thr Val Lys Gly  Lys Leu Leu 
    1190                 1195                 1200             


Thr Gly  Ile Lys Ser Pro Arg  Ser Tyr Thr Pro Lys  Pro Asn Pro 
    1205                 1210                 1215             


Val Ile  Arg Glu Glu Asp Lys  Asp Pro Val Tyr Leu  Tyr Phe Glu 
    1220                 1225                 1230             


Ser Met  Met Thr Cys Ala Arg  Val Arg Val Tyr Glu  Arg Lys Lys 
    1235                 1240                 1245             


Glu Asp  Gln Arg Gln Pro Ser  Ser Ser Ser Ser Pro  Ser Pro Ser 
    1250                 1255                 1260             


Phe Gln  Gln Gln Thr Ser Cys  His Ser Ser Pro Glu  Asn His Asn 
    1265                 1270                 1275             


Asn Ala  Lys Glu Pro Asp Ser  Glu Gln Gln Pro Leu  Lys Gln Leu 
    1280                 1285                 1290             


Thr Cys  Asp Leu Glu Asp Asp  Ser Asp Lys Leu Gln  Glu Lys Ser 
    1295                 1300                 1305             


Trp Lys  Ser Ser Cys Asn Glu  Gly Glu Ser Ser Ser  Thr Ser Tyr 
    1310                 1315                 1320             


Met His  Gln Arg Ser Pro Gly  Gly Pro Thr Lys Leu  Ile Glu Ile 
    1325                 1330                 1335             


Ile Ser  Asp Cys Asn Trp Glu  Glu Asp Arg Asn Lys  Ile Leu Ser 
    1340                 1345                 1350             


Ile Leu  Ser Gln His Ile Asn  Ser Asn Met Pro Gln  Ser Leu Lys 
    1355                 1360                 1365             


Val Gly  Ser Phe Ile Ile Glu  Leu Ala Ser Gln Arg  Lys Ser Arg 
    1370                 1375                 1380             


Gly Glu  Lys Asn Pro Pro Val  Tyr Ser Ser Arg Val  Lys Ile Ser 
    1385                 1390                 1395             


Met Pro  Ser Cys Gln Asp Gln  Asp Asp Met Ala Glu  Lys Ser Gly 
    1400                 1405                 1410             


Ser Glu  Thr Pro Asp Gly Pro  Leu Ser Pro Gly Lys  Met Glu Asp 
    1415                 1420                 1425             


Ile Ser  Pro Val Gln Thr Asp  Ala Leu Asp Ser Val  Arg Glu Arg 
    1430                 1435                 1440             


Leu His  Gly Gly Lys Gly Leu  Pro Phe Tyr Ala Gly  Leu Ser Pro 
    1445                 1450                 1455             


Ala Gly  Lys Leu Val Ala Tyr  Lys Arg Lys Pro Ser  Ser Ser Thr 
    1460                 1465                 1470             


Ser Gly  Leu Ile Gln Val Ala  Ser Asn Ala Lys Val  Ala Ala Ser 
    1475                 1480                 1485             


Arg Lys  Pro Arg Thr Leu Leu  Pro Ser Thr Ser Asn  Ser Lys Met 
    1490                 1495                 1500             


Ala Ser  Ser Ser Gly Thr Ala  Thr Asn Arg Pro Gly  Lys Asn Leu 
    1505                 1510                 1515             


Lys Ala  Phe Val Pro Ala Lys  Arg Pro Ile Glu Asn  Ala Ala Gln 
    1520                 1525                 1530             


Ile Pro  Val Ala Thr Pro Gln  Val Ser Pro Asn Thr  Val Lys Arg 
    1535                 1540                 1545             


Ala Gly  Pro Arg Leu Leu Leu  Ile Pro Val Gln Gln  Gly Ser Pro 
    1550                 1555                 1560             


Thr Leu  Arg Pro Val Ser Asn  Thr Gln Leu Gln Gly  His Arg Met 
    1565                 1570                 1575             


Val Leu  Gln Pro Val Arg Ser  Pro Ser Gly Met Asn  Leu Phe Arg 
    1580                 1585                 1590             


His Pro  Asn Gly Gln Ile Val  Gln Leu Leu Pro Leu  His Gln Leu 
    1595                 1600                 1605             


Arg Gly  Ser Asn Thr Gln Pro  Asn Leu Gln Pro Val  Met Phe Arg 
    1610                 1615                 1620             


Asn Pro  Gly Ser Val Met Gly  Ile Arg Leu Pro Ala  Pro Ser Lys 
    1625                 1630                 1635             


Pro Ser  Glu Thr Pro Pro Ser  Ser Thr Ser Ser Ser  Ala Phe Ser 
    1640                 1645                 1650             


Val Met  Asn Pro Val Ile Gln  Ala Val Gly Ser Ser  Ser Ala Val 
    1655                 1660                 1665             


Asn Val  Ile Thr Gln Ala Pro  Ser Leu Leu Ser Ser  Gly Ala Ser 
    1670                 1675                 1680             


Phe Val  Ser Gln Ala Gly Thr  Leu Thr Leu Arg Ile  Ser Pro Pro 
    1685                 1690                 1695             


Glu Pro  Gln Ser Phe Ala Ser  Lys Thr Gly Ser Glu  Thr Lys Ile 
    1700                 1705                 1710             


Thr Tyr  Ser Ser Gly Gly Gln  Pro Val Gly Thr Ala  Ser Leu Ile 
    1715                 1720                 1725             


Pro Leu  Gln Ser Gly Ser Phe  Ala Leu Leu Gln Leu  Pro Gly Gln 
    1730                 1735                 1740             


Lys Pro  Val Pro Ser Ser Ile  Leu Gln His Val Ala  Ser Leu Gln 
    1745                 1750                 1755             


Met Lys  Arg Glu Ser Gln Asn  Pro Asp Gln Lys Asp  Glu Thr Asn 
    1760                 1765                 1770             


Ser Ile  Lys Arg Glu Gln Glu  Thr Lys Lys Val Leu  Gln Ser Glu 
    1775                 1780                 1785             


Gly Glu  Ala Val Asp Pro Glu  Ala Asn Val Ile Lys  Gln Asn Ser 
    1790                 1795                 1800             


Gly Ala  Ala Thr Ser Glu Glu  Thr Leu Asn Asp Ser  Leu Glu Asp 
    1805                 1810                 1815             


Arg Gly  Asp His Leu Asp Glu  Glu Cys Leu Pro Glu  Glu Gly Cys 
    1820                 1825                 1830             


Ala Thr  Val Lys Pro Ser Glu  His Ser Cys Ile Thr  Gly Ser His 
    1835                 1840                 1845             


Thr Asp  Gln Asp Tyr Lys Asp  Val Asn Glu Glu Tyr  Gly Ala Arg 
    1850                 1855                 1860             


Asn Arg  Lys Ser Ser Lys Glu  Lys Val Ala Val Leu  Glu Val Arg 
    1865                 1870                 1875             


Thr Ile  Ser Glu Lys Ala Ser  Asn Lys Thr Val Gln  Asn Leu Ser 
    1880                 1885                 1890             


Lys Val  Gln His Gln Lys Leu  Gly Asp Val Lys Val  Glu Gln Gln 
    1895                 1900                 1905             


Lys Gly  Phe Asp Asn Pro Glu  Glu Asn Ser Ser Glu  Phe Pro Val 
    1910                 1915                 1920             


Thr Phe  Lys Glu Glu Ser Lys  Phe Glu Leu Ser Gly  Ser Lys Val 
    1925                 1930                 1935             


Met Glu  Gln Gln Ser Asn Leu  Gln Pro Glu Ala Lys  Glu Lys Glu 
    1940                 1945                 1950             


Cys Gly  Asp Ser Leu Glu Lys  Asp Arg Glu Arg Trp  Arg Lys His 
    1955                 1960                 1965             


Leu Lys  Gly Pro Leu Thr Arg  Lys Cys Val Gly Ala  Ser Gln Glu 
    1970                 1975                 1980             


Cys Lys  Lys Glu Ala Asp Glu  Gln Leu Ile Lys Glu  Thr Lys Thr 
    1985                 1990                 1995             


Cys Gln  Glu Asn Ser Asp Val  Phe Gln Gln Glu Gln  Gly Ile Ser 
    2000                 2005                 2010             


Asp Leu  Leu Gly Lys Ser Gly  Ile Thr Glu Asp Ala  Arg Val Leu 
    2015                 2020                 2025             


Lys Thr  Glu Cys Asp Ser Trp  Ser Arg Ile Ser Asn  Pro Ser Ala 
    2030                 2035                 2040             


Phe Ser  Ile Val Pro Arg Arg  Ala Ala Lys Ser Ser  Arg Gly Asn 
    2045                 2050                 2055             


Gly His  Phe Gln Gly His Leu  Leu Leu Pro Gly Glu  Gln Ile Gln 
    2060                 2065                 2070             


Pro Lys  Gln Glu Lys Lys Gly  Gly Arg Ser Ser Ala  Asp Phe Thr 
    2075                 2080                 2085             


Val Leu  Asp Leu Glu Glu Asp  Asp Glu Asp Asp Asn  Glu Lys Thr 
    2090                 2095                 2100             


Asp Asp  Ser Ile Asp Glu Ile  Val Asp Val Val Ser  Asp Tyr Gln 
    2105                 2110                 2115             


Ser Glu  Glu Val Asp Asp Val  Glu Lys Asn Asn Cys  Val Glu Tyr 
    2120                 2125                 2130             


Ile Glu  Asp Asp Glu Glu His  Val Asp Ile Glu Thr  Val Glu Glu 
    2135                 2140                 2145             


Leu Ser  Glu Glu Ile Asn Val  Ala His Leu Lys Thr  Thr Ala Ala 
    2150                 2155                 2160             


His Thr  Gln Ser Phe Lys Gln  Pro Ser Cys Thr His  Ile Ser Ala 
    2165                 2170                 2175             


Asp Glu  Lys Ala Ala Glu Arg  Ser Arg Lys Ala Pro  Pro Ile Pro 
    2180                 2185                 2190             


Leu Lys  Leu Lys Pro Asp Tyr  Trp Ser Asp Lys Leu  Gln Lys Glu 
    2195                 2200                 2205             


Ala Glu  Ala Phe Ala Tyr Tyr  Arg Arg Thr His Thr  Ala Asn Glu 
    2210                 2215                 2220             


Arg Arg  Arg Arg Gly Glu Met  Arg Asp Leu Phe Glu  Lys Leu Lys 
    2225                 2230                 2235             


Ile Thr  Leu Gly Leu Leu His  Ser Ser Lys Val Ser  Lys Ser Leu 
    2240                 2245                 2250             


Ile Leu  Thr Arg Ala Phe Ser  Glu Ile Gln Gly Leu  Thr Asp Gln 
    2255                 2260                 2265             


Ala Asp  Lys Leu Ile Gly Gln  Lys Asn Leu Leu Thr  Arg Lys Arg 
    2270                 2275                 2280             


Asn Ile  Leu Ile Arg Lys Val  Ser Ser Leu Ser Gly  Lys Thr Glu 
    2285                 2290                 2295             


Glu Val  Val Leu Lys Lys Leu  Glu Tyr Ile Tyr Ala  Lys Gln Gln 
    2300                 2305                 2310             


Ala Leu  Glu Ala Gln Lys Arg  Lys Lys Lys Met Gly  Ser Asp Glu 
    2315                 2320                 2325             


Phe Asp  Ile Ser Pro Arg Ile  Ser Lys Gln Gln Glu  Gly Ser Ser 
    2330                 2335                 2340             


Ala Ser  Ser Val Asp Leu Gly  Gln Met Phe Ile Asn  Asn Arg Arg 
    2345                 2350                 2355             


Gly Lys  Pro Leu Ile Leu Ser  Arg Lys Lys Asp Gln  Ala Thr Glu 
    2360                 2365                 2370             


Asn Thr  Ser Pro Leu Asn Thr  Pro His Thr Ser Ala  Asn Leu Val 
    2375                 2380                 2385             


Met Thr  Pro Gln Gly Gln Leu  Leu Thr Leu Lys Gly  Pro Leu Phe 
    2390                 2395                 2400             


Ser Gly  Pro Val Val Ala Val  Ser Pro Asp Leu Leu  Glu Ser Asp 
    2405                 2410                 2415             


Leu Lys  Pro Gln Val Ala Gly  Ser Ala Val Ala Leu  Pro Glu Asn 
    2420                 2425                 2430             


Asp Asp  Leu Phe Met Met Pro  Arg Ile Val Asn Val  Thr Ser Leu 
    2435                 2440                 2445             


Ala Thr  Glu Gly Gly Leu Val  Asp Met Gly Gly Ser  Lys Tyr Pro 
    2450                 2455                 2460             


His Glu  Val Pro Asp Ser Lys  Pro Ser Asp His Leu  Lys Asp Thr 
    2465                 2470                 2475             


Val Arg  Asn Glu Asp Asn Ser  Leu Glu Asp Lys Gly  Arg Ile Ser 
    2480                 2485                 2490             


Ser Arg  Gly Asn Arg Asp Gly  Arg Val Thr Leu Gly  Pro Thr Gln 
    2495                 2500                 2505             


Val Phe  Leu Ala Asn Lys Asp  Ser Gly Tyr Pro Gln  Ile Val Asp 
    2510                 2515                 2520             


Val Ser  Asn Met Gln Lys Ala  Gln Glu Phe Leu Pro  Lys Lys Ile 
    2525                 2530                 2535             


Ser Gly  Asp Met Arg Gly Ile  Gln Tyr Lys Trp Lys  Glu Ser Glu 
    2540                 2545                 2550             


Ser Arg  Gly Glu Arg Val Lys  Ser Lys Asp Ser Ser  Phe His Lys 
    2555                 2560                 2565             


Leu Lys  Met Lys Asp Leu Lys  Asp Ser Ser Ile Glu  Met Glu Leu 
    2570                 2575                 2580             


Arg Lys  Val Thr Ser Ala Ile  Glu Glu Ala Ala Leu  Asp Ser Ser 
    2585                 2590                 2595             


Glu Leu  Leu Thr Asn Met Glu  Asp Glu Asp Asp Thr  Asp Glu Thr 
    2600                 2605                 2610             


Leu Thr  Ser Leu Leu Asn Glu  Ile Ala Phe Leu Asn  Gln Gln Leu 
    2615                 2620                 2625             


Asn Asp  Asp Ser Val Gly Leu  Ala Glu Leu Pro Ser  Ser Met Asp 
    2630                 2635                 2640             


Thr Glu  Phe Pro Gly Asp Ala  Arg Arg Ala Phe Ile  Ser Lys Val 
    2645                 2650                 2655             


Pro Pro  Gly Ser Arg Ala Thr  Phe Gln Val Glu His  Leu Gly Thr 
    2660                 2665                 2670             


Gly Leu  Lys Glu Leu Pro Asp  Val Gln Gly Glu Ser  Asp Ser Ile 
    2675                 2680                 2685             


Ser Pro  Leu Leu Leu His Leu  Glu Asp Asp Asp Phe  Ser Glu Asn 
    2690                 2695                 2700             


Glu Lys  Gln Leu Ala Glu Pro  Ala Ser Glu Pro Asp  Val Leu Lys 
    2705                 2710                 2715             


Ile Val  Ile Asp Ser Glu Ile  Lys Asp Ser Leu Leu  Ser Asn Lys 
    2720                 2725                 2730             


Lys Ala  Ile Asp Gly Gly Lys  Asn Thr Ser Gly Leu  Pro Ala Glu 
    2735                 2740                 2745             


Pro Glu  Ser Val Ser Ser Pro  Pro Thr Leu His Met  Lys Thr Gly 
    2750                 2755                 2760             


Leu Glu  Asn Ser Asn Ser Thr  Asp Thr Leu Trp Arg  Pro Met Pro 
    2765                 2770                 2775             


Lys Leu  Ala Pro Leu Gly Leu  Lys Val Ala Asn Pro  Ser Ser Asp 
    2780                 2785                 2790             


Ala Asp  Gly Gln Ser Leu Lys  Val Met Pro Cys Leu  Ala Pro Ile 
    2795                 2800                 2805             


Ala Ala  Lys Val Gly Ser Val  Gly His Lys Met Asn  Leu Thr Gly 
    2810                 2815                 2820             


Asn Asp  Gln Glu Gly Arg Glu  Ser Lys Val Met Pro  Thr Leu Ala 
    2825                 2830                 2835             


Pro Val  Val Ala Lys Leu Gly  Asn Ser Gly Ala Ser  Pro Ser Ser 
    2840                 2845                 2850             


Ala Gly  Lys 
    2855     


<210>  8655
<211>  3065
<212>  PRT
<213>  Homo Sapiens

<400>  8655

Met Glu Glu Lys Gln Gln Ile Ile Leu Ala Asn Gln Asp Gly Gly Thr 
1               5                   10                  15      


Val Ala Gly Ala Ala Pro Thr Phe Phe Val Ile Leu Lys Gln Pro Gly 
            20                  25                  30          


Asn Gly Lys Thr Asp Gln Gly Ile Leu Val Thr Asn Gln Asp Ala Cys 
        35                  40                  45              


Ala Leu Ala Ser Ser Val Ser Ser Pro Val Lys Ser Lys Gly Lys Ile 
    50                  55                  60                  


Cys Leu Pro Ala Asp Cys Thr Val Gly Gly Ile Thr Val Thr Leu Asp 
65                  70                  75                  80  


Asn Asn Ser Met Trp Asn Glu Phe Tyr His Arg Ser Thr Glu Met Ile 
                85                  90                  95      


Leu Thr Lys Gln Gly Arg Arg Met Phe Pro Tyr Cys Arg Tyr Trp Ile 
            100                 105                 110         


Thr Gly Leu Asp Ser Asn Leu Lys Tyr Ile Leu Val Met Asp Ile Ser 
        115                 120                 125             


Pro Val Asp Asn His Arg Tyr Lys Trp Asn Gly Arg Trp Trp Glu Pro 
    130                 135                 140                 


Ser Gly Lys Ala Glu Pro His Val Leu Gly Arg Val Phe Ile His Pro 
145                 150                 155                 160 


Glu Ser Pro Ser Thr Gly His Tyr Trp Met His Gln Pro Val Ser Phe 
                165                 170                 175     


Tyr Lys Leu Lys Leu Thr Asn Asn Thr Leu Asp Gln Glu Gly His Ile 
            180                 185                 190         


Ile Leu His Ser Met His Arg Tyr Leu Pro Arg Leu His Leu Val Pro 
        195                 200                 205             


Ala Glu Lys Ala Val Glu Val Ile Gln Leu Asn Gly Pro Gly Val His 
    210                 215                 220                 


Thr Phe Thr Phe Pro Gln Thr Glu Phe Phe Ala Val Thr Ala Tyr Gln 
225                 230                 235                 240 


Asn Ile Gln Ile Thr Gln Leu Lys Ile Asp Tyr Asn Pro Phe Ala Lys 
                245                 250                 255     


Gly Phe Arg Asp Asp Gly Leu Asn Asn Lys Pro Gln Arg Asp Gly Lys 
            260                 265                 270         


Gln Lys Asn Ser Ser Asp Gln Glu Gly Asn Asn Ile Ser Ser Ser Ser 
        275                 280                 285             


Gly His Arg Val Arg Leu Thr Glu Gly Gln Gly Ser Glu Ile Gln Pro 
    290                 295                 300                 


Gly Asp Leu Asp Pro Leu Ser Arg Gly His Glu Thr Ser Gly Lys Gly 
305                 310                 315                 320 


Leu Glu Lys Thr Ser Leu Asn Ile Lys Arg Asp Phe Leu Gly Phe Met 
                325                 330                 335     


Asp Thr Asp Ser Ala Leu Ser Glu Val Pro Gln Leu Lys Gln Glu Ile 
            340                 345                 350         


Ser Glu Cys Leu Ile Ala Ser Ser Phe Glu Asp Asp Ser Arg Val Ala 
        355                 360                 365             


Ser Pro Leu Asp Gln Asn Gly Ser Phe Asn Val Val Ile Lys Glu Glu 
    370                 375                 380                 


Pro Leu Asp Asp Tyr Asp Tyr Glu Leu Gly Glu Cys Pro Glu Gly Val 
385                 390                 395                 400 


Thr Val Lys Gln Glu Glu Thr Asp Glu Glu Thr Asp Val Tyr Ser Asn 
                405                 410                 415     


Ser Asp Asp Asp Pro Ile Leu Glu Lys Gln Leu Lys Arg His Asn Lys 
            420                 425                 430         


Val Asp Asn Pro Glu Ala Asp His Leu Ser Ser Lys Trp Leu Pro Ser 
        435                 440                 445             


Ser Pro Ser Gly Val Ala Lys Ala Lys Met Phe Lys Leu Asp Thr Gly 
    450                 455                 460                 


Lys Met Pro Val Val Tyr Leu Glu Pro Cys Ala Val Thr Arg Ser Thr 
465                 470                 475                 480 


Val Lys Ile Ser Glu Leu Pro Asp Asn Met Leu Ser Thr Ser Arg Lys 
                485                 490                 495     


Asp Lys Ser Ser Met Leu Ala Glu Leu Glu Tyr Leu Pro Thr Tyr Ile 
            500                 505                 510         


Glu Asn Ser Asn Glu Thr Ala Phe Cys Leu Gly Lys Glu Ser Glu Asn 
        515                 520                 525             


Gly Leu Arg Lys His Ser Pro Asp Leu Arg Val Val Gln Lys Tyr Pro 
    530                 535                 540                 


Leu Leu Lys Glu Pro Gln Trp Lys Tyr Pro Asp Ile Ser Asp Ser Ile 
545                 550                 555                 560 


Ser Thr Glu Arg Ile Leu Asp Asp Ser Lys Asp Ser Val Gly Asp Ser 
                565                 570                 575     


Leu Ser Gly Lys Glu Asp Leu Gly Arg Lys Arg Thr Thr Met Leu Lys 
            580                 585                 590         


Ile Ala Thr Ala Ala Lys Val Val Asn Ala Asn Gln Asn Ala Ser Pro 
        595                 600                 605             


Asn Val Pro Gly Lys Arg Gly Arg Pro Arg Lys Leu Lys Leu Cys Lys 
    610                 615                 620                 


Ala Gly Arg Pro Pro Lys Asn Thr Gly Lys Ser Leu Ile Ser Thr Lys 
625                 630                 635                 640 


Asn Thr Pro Val Ser Pro Gly Ser Thr Phe Pro Asp Val Lys Pro Asp 
                645                 650                 655     


Leu Glu Asp Val Asp Gly Val Leu Phe Val Ser Phe Glu Ser Lys Glu 
            660                 665                 670         


Ala Leu Asp Ile His Ala Val Asp Gly Thr Thr Glu Glu Ser Ser Ser 
        675                 680                 685             


Leu Gln Ala Ser Thr Thr Asn Asp Ser Gly Tyr Arg Ala Arg Ile Ser 
    690                 695                 700                 


Gln Leu Glu Lys Glu Leu Ile Glu Asp Leu Lys Thr Leu Arg His Lys 
705                 710                 715                 720 


Gln Val Ile His Pro Gly Leu Gln Glu Val Gly Leu Lys Leu Asn Ser 
                725                 730                 735     


Val Asp Pro Thr Met Ser Ile Asp Leu Lys Tyr Leu Gly Val Gln Leu 
            740                 745                 750         


Pro Leu Ala Pro Ala Thr Ser Phe Pro Phe Trp Asn Leu Thr Gly Thr 
        755                 760                 765             


Asn Pro Ala Ser Pro Asp Ala Gly Phe Pro Phe Val Ser Arg Thr Gly 
    770                 775                 780                 


Lys Thr Asn Asp Phe Thr Lys Ile Lys Gly Trp Arg Gly Lys Phe His 
785                 790                 795                 800 


Ser Ala Ser Ala Ser Arg Asn Glu Gly Gly Asn Ser Glu Ser Ser Leu 
                805                 810                 815     


Lys Asn Arg Ser Ala Phe Cys Ser Asp Lys Leu Asp Glu Tyr Leu Glu 
            820                 825                 830         


Asn Glu Gly Lys Leu Met Glu Thr Ser Met Gly Phe Ser Ser Asn Ala 
        835                 840                 845             


Pro Thr Ser Pro Val Val Tyr Gln Leu Pro Thr Lys Ser Thr Ser Tyr 
    850                 855                 860                 


Val Arg Thr Leu Asp Ser Val Leu Lys Lys Gln Ser Thr Ile Ser Pro 
865                 870                 875                 880 


Ser Thr Ser Tyr Ser Leu Lys Pro His Ser Val Pro Pro Val Ser Arg 
                885                 890                 895     


Lys Ala Lys Ser Gln Asn Arg Gln Ala Thr Phe Ser Gly Arg Thr Lys 
            900                 905                 910         


Ser Ser Tyr Lys Ser Ile Leu Pro Tyr Pro Val Ser Pro Lys Gln Lys 
        915                 920                 925             


Tyr Ser His Val Ile Leu Gly Asp Lys Val Thr Lys Asn Ser Ser Gly 
    930                 935                 940                 


Ile Ile Ser Glu Asn Gln Ala Asn Asn Phe Val Val Pro Thr Leu Asp 
945                 950                 955                 960 


Glu Asn Ile Phe Pro Lys Gln Ile Ser Leu Arg Gln Ala Gln Gln Gln 
                965                 970                 975     


Gln Gln Gln Gln Gln Gly Ser Arg Pro Pro Gly Leu Ser Lys Ser Gln 
            980                 985                 990         


Val Lys Leu Met Asp Leu Glu Asp  Cys Ala Leu Trp Glu  Gly Lys Pro 
        995                 1000                 1005             


Arg Thr  Tyr Ile Thr Glu Glu  Arg Ala Asp Val Ser  Leu Thr Thr 
    1010                 1015                 1020             


Leu Leu  Thr Ala Gln Ala Ser  Leu Lys Thr Lys Pro  Ile His Thr 
    1025                 1030                 1035             


Ile Ile  Arg Lys Arg Ala Pro  Pro Cys Asn Asn Asp  Phe Cys Arg 
    1040                 1045                 1050             


Leu Gly  Cys Val Cys Ser Ser  Leu Ala Leu Glu Lys  Arg Gln Pro 
    1055                 1060                 1065             


Ala His  Cys Arg Arg Pro Asp  Cys Met Phe Gly Cys  Thr Cys Leu 
    1070                 1075                 1080             


Lys Arg  Lys Val Val Leu Val  Lys Gly Gly Ser Lys  Thr Lys His 
    1085                 1090                 1095             


Phe Gln  Arg Lys Ala Ala His  Arg Asp Pro Val Phe  Tyr Asp Thr 
    1100                 1105                 1110             


Leu Gly  Glu Glu Ala Arg Glu  Glu Glu Glu Gly Ile  Arg Glu Glu 
    1115                 1120                 1125             


Glu Glu  Gln Leu Lys Glu Lys  Lys Lys Arg Lys Lys  Leu Glu Tyr 
    1130                 1135                 1140             


Thr Ile  Cys Glu Thr Glu Pro  Glu Gln Pro Val Arg  His Tyr Pro 
    1145                 1150                 1155             


Leu Trp  Val Lys Val Glu Gly  Glu Val Asp Pro Glu  Pro Val Tyr 
    1160                 1165                 1170             


Ile Pro  Thr Pro Ser Val Ile  Glu Pro Met Lys Pro  Leu Leu Leu 
    1175                 1180                 1185             


Pro Gln  Pro Glu Val Leu Ser  Pro Thr Val Lys Gly  Lys Leu Leu 
    1190                 1195                 1200             


Thr Gly  Ile Lys Ser Pro Arg  Ser Tyr Thr Pro Lys  Pro Asn Pro 
    1205                 1210                 1215             


Val Ile  Arg Glu Glu Asp Lys  Asp Pro Val Tyr Leu  Tyr Phe Glu 
    1220                 1225                 1230             


Ser Met  Met Thr Cys Ala Arg  Val Arg Val Tyr Glu  Arg Lys Lys 
    1235                 1240                 1245             


Glu Asp  Gln Arg Gln Pro Ser  Ser Ser Ser Ser Pro  Ser Pro Ser 
    1250                 1255                 1260             


Phe Gln  Gln Gln Thr Ser Cys  His Ser Ser Pro Glu  Asn His Asn 
    1265                 1270                 1275             


Asn Ala  Lys Glu Pro Asp Ser  Glu Gln Gln Pro Leu  Lys Gln Leu 
    1280                 1285                 1290             


Thr Cys  Asp Leu Glu Asp Asp  Ser Asp Lys Leu Gln  Glu Lys Ser 
    1295                 1300                 1305             


Trp Lys  Ser Ser Cys Asn Glu  Gly Glu Ser Ser Ser  Thr Ser Tyr 
    1310                 1315                 1320             


Met His  Gln Arg Ser Pro Gly  Gly Pro Thr Lys Leu  Ile Glu Ile 
    1325                 1330                 1335             


Ile Ser  Asp Cys Asn Trp Glu  Glu Asp Arg Asn Lys  Ile Leu Ser 
    1340                 1345                 1350             


Ile Leu  Ser Gln His Ile Asn  Ser Asn Met Pro Gln  Ser Leu Lys 
    1355                 1360                 1365             


Val Gly  Ser Phe Ile Ile Glu  Leu Ala Ser Gln Arg  Lys Ser Arg 
    1370                 1375                 1380             


Gly Glu  Lys Asn Pro Pro Val  Tyr Ser Ser Arg Val  Lys Ile Ser 
    1385                 1390                 1395             


Met Pro  Ser Cys Gln Asp Gln  Asp Asp Met Ala Glu  Lys Ser Gly 
    1400                 1405                 1410             


Ser Glu  Thr Pro Asp Gly Pro  Leu Ser Pro Gly Lys  Met Glu Asp 
    1415                 1420                 1425             


Ile Ser  Pro Val Gln Thr Asp  Ala Leu Asp Ser Val  Arg Glu Arg 
    1430                 1435                 1440             


Leu His  Gly Gly Lys Gly Leu  Pro Phe Tyr Ala Gly  Leu Ser Pro 
    1445                 1450                 1455             


Ala Gly  Lys Leu Val Ala Tyr  Lys Arg Lys Pro Ser  Ser Ser Thr 
    1460                 1465                 1470             


Ser Gly  Leu Ile Gln Val Ala  Ser Asn Ala Lys Val  Ala Ala Ser 
    1475                 1480                 1485             


Arg Lys  Pro Arg Thr Leu Leu  Pro Ser Thr Ser Asn  Ser Lys Met 
    1490                 1495                 1500             


Ala Ser  Ser Ser Gly Thr Ala  Thr Asn Arg Pro Gly  Lys Asn Leu 
    1505                 1510                 1515             


Lys Ala  Phe Val Pro Ala Lys  Arg Pro Ile Ala Ala  Arg Pro Ser 
    1520                 1525                 1530             


Pro Gly  Gly Val Phe Thr Gln  Phe Val Met Ser Lys  Val Gly Ala 
    1535                 1540                 1545             


Leu Gln  Gln Lys Ile Pro Gly  Val Ser Thr Pro Gln  Thr Leu Ala 
    1550                 1555                 1560             


Gly Thr  Gln Lys Phe Ser Ile  Arg Pro Ser Pro Val  Met Val Val 
    1565                 1570                 1575             


Thr Pro  Val Val Ser Ser Glu  Pro Val Gln Val Cys  Ser Pro Val 
    1580                 1585                 1590             


Thr Ala  Ala Val Thr Thr Thr  Thr Pro Gln Val Phe  Leu Glu Asn 
    1595                 1600                 1605             


Thr Thr  Ala Val Thr Pro Met  Thr Ala Ile Ser Asp  Val Glu Thr 
    1610                 1615                 1620             


Lys Glu  Thr Thr Tyr Ser Ser  Gly Ala Thr Thr Thr  Gly Val Val 
    1625                 1630                 1635             


Glu Val  Ser Glu Thr Asn Thr  Ser Thr Ser Val Thr  Ser Thr Gln 
    1640                 1645                 1650             


Ser Thr  Ala Thr Val Asn Leu  Thr Lys Thr Thr Gly  Ile Thr Thr 
    1655                 1660                 1665             


Pro Val  Ala Ser Val Ala Phe  Pro Lys Ser Leu Val  Ala Ser Pro 
    1670                 1675                 1680             


Ser Thr  Ile Thr Leu Pro Val  Ala Ser Thr Ala Ser  Thr Ser Leu 
    1685                 1690                 1695             


Val Val  Val Thr Ala Ala Ala  Ser Ser Ser Met Val  Thr Thr Pro 
    1700                 1705                 1710             


Thr Ser  Ser Leu Gly Ser Val  Pro Ile Ile Leu Ser  Gly Ile Asn 
    1715                 1720                 1725             


Gly Ser  Pro Pro Val Ser Gln  Arg Pro Glu Asn Ala  Ala Gln Ile 
    1730                 1735                 1740             


Pro Val  Ala Thr Pro Gln Val  Ser Pro Asn Thr Val  Lys Arg Ala 
    1745                 1750                 1755             


Gly Pro  Arg Leu Leu Leu Ile  Pro Val Gln Gln Gly  Ser Pro Thr 
    1760                 1765                 1770             


Leu Arg  Pro Val Ser Asn Thr  Gln Leu Gln Gly His  Arg Met Val 
    1775                 1780                 1785             


Leu Gln  Pro Val Arg Ser Pro  Ser Gly Met Asn Leu  Phe Arg His 
    1790                 1795                 1800             


Pro Asn  Gly Gln Ile Val Gln  Leu Leu Pro Leu His  Gln Leu Arg 
    1805                 1810                 1815             


Gly Ser  Asn Thr Gln Pro Asn  Leu Gln Pro Val Met  Phe Arg Asn 
    1820                 1825                 1830             


Pro Gly  Ser Val Met Gly Ile  Arg Leu Pro Ala Pro  Ser Lys Pro 
    1835                 1840                 1845             


Ser Glu  Thr Pro Pro Ser Ser  Thr Ser Ser Ser Ala  Phe Ser Val 
    1850                 1855                 1860             


Met Asn  Pro Val Ile Gln Ala  Val Gly Ser Ser Ser  Ala Val Asn 
    1865                 1870                 1875             


Val Ile  Thr Gln Ala Pro Ser  Leu Leu Ser Ser Gly  Ala Ser Phe 
    1880                 1885                 1890             


Val Ser  Gln Ala Gly Thr Leu  Thr Leu Arg Ile Ser  Pro Pro Glu 
    1895                 1900                 1905             


Pro Gln  Ser Phe Ala Ser Lys  Thr Gly Ser Glu Thr  Lys Ile Thr 
    1910                 1915                 1920             


Tyr Ser  Ser Gly Gly Gln Pro  Val Gly Thr Ala Ser  Leu Ile Pro 
    1925                 1930                 1935             


Leu Gln  Ser Gly Ser Phe Ala  Leu Leu Gln Leu Pro  Gly Gln Lys 
    1940                 1945                 1950             


Pro Val  Pro Ser Ser Ile Leu  Gln His Val Ala Ser  Leu Gln Met 
    1955                 1960                 1965             


Lys Arg  Glu Ser Gln Asn Pro  Asp Gln Lys Asp Glu  Thr Asn Ser 
    1970                 1975                 1980             


Ile Lys  Arg Glu Gln Glu Thr  Lys Lys Val Leu Gln  Ser Glu Gly 
    1985                 1990                 1995             


Glu Ala  Val Asp Pro Glu Ala  Asn Val Ile Lys Gln  Asn Ser Gly 
    2000                 2005                 2010             


Ala Ala  Thr Ser Glu Glu Thr  Leu Asn Asp Ser Leu  Glu Asp Arg 
    2015                 2020                 2025             


Gly Asp  His Leu Asp Glu Glu  Cys Leu Pro Glu Glu  Gly Cys Ala 
    2030                 2035                 2040             


Thr Val  Lys Pro Ser Glu His  Ser Cys Ile Thr Gly  Ser His Thr 
    2045                 2050                 2055             


Asp Gln  Asp Tyr Lys Asp Val  Asn Glu Glu Tyr Gly  Ala Arg Asn 
    2060                 2065                 2070             


Arg Lys  Ser Ser Lys Glu Lys  Val Ala Val Leu Glu  Val Arg Thr 
    2075                 2080                 2085             


Ile Ser  Glu Lys Ala Ser Asn  Lys Thr Val Gln Asn  Leu Ser Lys 
    2090                 2095                 2100             


Val Gln  His Gln Lys Leu Gly  Asp Val Lys Val Glu  Gln Gln Lys 
    2105                 2110                 2115             


Gly Phe  Asp Asn Pro Glu Glu  Asn Ser Ser Glu Phe  Pro Val Thr 
    2120                 2125                 2130             


Phe Lys  Glu Glu Ser Lys Phe  Glu Leu Ser Gly Ser  Lys Val Met 
    2135                 2140                 2145             


Glu Gln  Gln Ser Asn Leu Gln  Pro Glu Ala Lys Glu  Lys Glu Cys 
    2150                 2155                 2160             


Gly Asp  Ser Leu Glu Lys Asp  Arg Glu Arg Trp Arg  Lys His Leu 
    2165                 2170                 2175             


Lys Gly  Pro Leu Thr Arg Lys  Cys Val Gly Ala Ser  Gln Glu Cys 
    2180                 2185                 2190             


Lys Lys  Glu Ala Asp Glu Gln  Leu Ile Lys Glu Thr  Lys Thr Cys 
    2195                 2200                 2205             


Gln Glu  Asn Ser Asp Val Phe  Gln Gln Glu Gln Gly  Ile Ser Asp 
    2210                 2215                 2220             


Leu Leu  Gly Lys Ser Gly Ile  Thr Glu Asp Ala Arg  Val Leu Lys 
    2225                 2230                 2235             


Thr Glu  Cys Asp Ser Trp Ser  Arg Ile Ser Asn Pro  Ser Ala Phe 
    2240                 2245                 2250             


Ser Ile  Val Pro Arg Arg Ala  Ala Lys Ser Ser Arg  Gly Asn Gly 
    2255                 2260                 2265             


His Phe  Gln Gly His Leu Leu  Leu Pro Gly Glu Gln  Ile Gln Pro 
    2270                 2275                 2280             


Lys Gln  Glu Lys Lys Gly Gly  Arg Ser Ser Ala Asp  Phe Thr Val 
    2285                 2290                 2295             


Leu Asp  Leu Glu Glu Asp Asp  Glu Asp Asp Asn Glu  Lys Thr Asp 
    2300                 2305                 2310             


Asp Ser  Ile Asp Glu Ile Val  Asp Val Val Ser Asp  Tyr Gln Ser 
    2315                 2320                 2325             


Glu Glu  Val Asp Asp Val Glu  Lys Asn Asn Cys Val  Glu Tyr Ile 
    2330                 2335                 2340             


Glu Asp  Asp Glu Glu His Val  Asp Ile Glu Thr Val  Glu Glu Leu 
    2345                 2350                 2355             


Ser Glu  Glu Ile Asn Val Ala  His Leu Lys Thr Thr  Ala Ala His 
    2360                 2365                 2370             


Thr Gln  Ser Phe Lys Gln Pro  Ser Cys Thr His Ile  Ser Ala Asp 
    2375                 2380                 2385             


Glu Lys  Ala Ala Glu Arg Ser  Arg Lys Ala Pro Pro  Ile Pro Leu 
    2390                 2395                 2400             


Lys Leu  Lys Pro Asp Tyr Trp  Ser Asp Lys Leu Gln  Lys Glu Ala 
    2405                 2410                 2415             


Glu Ala  Phe Ala Tyr Tyr Arg  Arg Thr His Thr Ala  Asn Glu Arg 
    2420                 2425                 2430             


Arg Arg  Arg Gly Glu Met Arg  Asp Leu Phe Glu Lys  Leu Lys Ile 
    2435                 2440                 2445             


Thr Leu  Gly Leu Leu His Ser  Ser Lys Val Ser Lys  Ser Leu Ile 
    2450                 2455                 2460             


Leu Thr  Arg Ala Phe Ser Glu  Ile Gln Gly Leu Thr  Asp Gln Ala 
    2465                 2470                 2475             


Asp Lys  Leu Ile Gly Gln Lys  Asn Leu Leu Thr Arg  Lys Arg Asn 
    2480                 2485                 2490             


Ile Leu  Ile Arg Lys Val Ser  Ser Leu Ser Gly Lys  Thr Glu Glu 
    2495                 2500                 2505             


Val Val  Leu Lys Lys Leu Glu  Tyr Ile Tyr Ala Lys  Gln Gln Ala 
    2510                 2515                 2520             


Leu Glu  Ala Gln Lys Arg Lys  Lys Lys Met Gly Ser  Asp Glu Phe 
    2525                 2530                 2535             


Asp Ile  Ser Pro Arg Ile Ser  Lys Gln Gln Glu Gly  Ser Ser Ala 
    2540                 2545                 2550             


Ser Ser  Val Asp Leu Gly Gln  Met Phe Ile Asn Asn  Arg Arg Gly 
    2555                 2560                 2565             


Lys Pro  Leu Ile Leu Ser Arg  Lys Lys Asp Gln Ala  Thr Glu Asn 
    2570                 2575                 2580             


Thr Ser  Pro Leu Asn Thr Pro  His Thr Ser Ala Asn  Leu Val Met 
    2585                 2590                 2595             


Thr Pro  Gln Gly Gln Leu Leu  Thr Leu Lys Gly Pro  Leu Phe Ser 
    2600                 2605                 2610             


Gly Pro  Val Val Ala Val Ser  Pro Asp Leu Leu Glu  Ser Asp Leu 
    2615                 2620                 2625             


Lys Pro  Gln Val Ala Gly Ser  Ala Val Ala Leu Pro  Glu Asn Asp 
    2630                 2635                 2640             


Asp Leu  Phe Met Met Pro Arg  Ile Val Asn Val Thr  Ser Leu Ala 
    2645                 2650                 2655             


Thr Glu  Gly Gly Leu Val Asp  Met Gly Gly Ser Lys  Tyr Pro His 
    2660                 2665                 2670             


Glu Val  Pro Asp Ser Lys Pro  Ser Asp His Leu Lys  Asp Thr Val 
    2675                 2680                 2685             


Arg Asn  Glu Asp Asn Ser Leu  Glu Asp Lys Gly Arg  Ile Ser Ser 
    2690                 2695                 2700             


Arg Gly  Asn Arg Asp Gly Arg  Val Thr Leu Gly Pro  Thr Gln Val 
    2705                 2710                 2715             


Phe Leu  Ala Asn Lys Asp Ser  Gly Tyr Pro Gln Ile  Val Asp Val 
    2720                 2725                 2730             


Ser Asn  Met Gln Lys Ala Gln  Glu Phe Leu Pro Lys  Lys Ile Ser 
    2735                 2740                 2745             


Gly Asp  Met Arg Gly Ile Gln  Tyr Lys Trp Lys Glu  Ser Glu Ser 
    2750                 2755                 2760             


Arg Gly  Glu Arg Val Lys Ser  Lys Asp Ser Ser Phe  His Lys Leu 
    2765                 2770                 2775             


Lys Met  Lys Asp Leu Lys Asp  Ser Ser Ile Glu Met  Glu Leu Arg 
    2780                 2785                 2790             


Lys Val  Thr Ser Ala Ile Glu  Glu Ala Ala Leu Asp  Ser Ser Glu 
    2795                 2800                 2805             


Leu Leu  Thr Asn Met Glu Asp  Glu Asp Asp Thr Asp  Glu Thr Leu 
    2810                 2815                 2820             


Thr Ser  Leu Leu Asn Glu Ile  Ala Phe Leu Asn Gln  Gln Leu Asn 
    2825                 2830                 2835             


Asp Asp  Ser Val Gly Leu Ala  Glu Leu Pro Ser Ser  Met Asp Thr 
    2840                 2845                 2850             


Glu Phe  Pro Gly Asp Ala Arg  Arg Ala Phe Ile Ser  Lys Val Pro 
    2855                 2860                 2865             


Pro Gly  Ser Arg Ala Thr Phe  Gln Val Glu His Leu  Gly Thr Gly 
    2870                 2875                 2880             


Leu Lys  Glu Leu Pro Asp Val  Gln Gly Glu Ser Asp  Ser Ile Ser 
    2885                 2890                 2895             


Pro Leu  Leu Leu His Leu Glu  Asp Asp Asp Phe Ser  Glu Asn Glu 
    2900                 2905                 2910             


Lys Gln  Leu Ala Glu Pro Ala  Ser Glu Pro Asp Val  Leu Lys Ile 
    2915                 2920                 2925             


Val Ile  Asp Ser Glu Ile Lys  Asp Ser Leu Leu Ser  Asn Lys Lys 
    2930                 2935                 2940             


Ala Ile  Asp Gly Gly Lys Asn  Thr Ser Gly Leu Pro  Ala Glu Pro 
    2945                 2950                 2955             


Glu Ser  Val Ser Ser Pro Pro  Thr Leu His Met Lys  Thr Gly Leu 
    2960                 2965                 2970             


Glu Asn  Ser Asn Ser Thr Asp  Thr Leu Trp Arg Pro  Met Pro Lys 
    2975                 2980                 2985             


Leu Ala  Pro Leu Gly Leu Lys  Val Ala Asn Pro Ser  Ser Asp Ala 
    2990                 2995                 3000             


Asp Gly  Gln Ser Leu Lys Val  Met Pro Cys Leu Ala  Pro Ile Ala 
    3005                 3010                 3015             


Ala Lys  Val Gly Ser Val Gly  His Lys Met Asn Leu  Thr Gly Asn 
    3020                 3025                 3030             


Asp Gln  Glu Gly Arg Glu Ser  Lys Val Met Pro Thr  Leu Ala Pro 
    3035                 3040                 3045             


Val Val  Ala Lys Leu Gly Asn  Ser Gly Ala Ser Pro  Ser Ser Ala 
    3050                 3055                 3060             


Gly Lys  
    3065 


<210>  8656
<211>  2856
<212>  PRT
<213>  Homo Sapiens

<400>  8656

Met Glu Glu Lys Gln Gln Ile Ile Leu Ala Asn Gln Asp Gly Gly Thr 
1               5                   10                  15      


Val Ala Gly Ala Ala Pro Thr Phe Phe Val Ile Leu Lys Gln Pro Gly 
            20                  25                  30          


Asn Gly Lys Thr Asp Gln Gly Ile Leu Val Thr Asn Gln Asp Ala Cys 
        35                  40                  45              


Ala Leu Ala Ser Ser Val Ser Ser Pro Val Lys Ser Lys Gly Lys Ile 
    50                  55                  60                  


Cys Leu Pro Ala Asp Cys Thr Val Gly Gly Ile Thr Val Thr Leu Asp 
65                  70                  75                  80  


Asn Asn Ser Met Trp Asn Glu Phe Tyr His Arg Ser Thr Glu Met Ile 
                85                  90                  95      


Leu Thr Lys Gln Gly Arg Arg Met Phe Pro Tyr Cys Arg Tyr Trp Ile 
            100                 105                 110         


Thr Gly Leu Asp Ser Asn Leu Lys Tyr Ile Leu Val Met Asp Ile Ser 
        115                 120                 125             


Pro Val Asp Asn His Arg Tyr Lys Trp Asn Gly Arg Trp Trp Glu Pro 
    130                 135                 140                 


Ser Gly Lys Ala Glu Pro His Val Leu Gly Arg Val Phe Ile His Pro 
145                 150                 155                 160 


Glu Ser Pro Ser Thr Gly His Tyr Trp Met His Gln Pro Val Ser Phe 
                165                 170                 175     


Tyr Lys Leu Lys Leu Thr Asn Asn Thr Leu Asp Gln Glu Gly His Ile 
            180                 185                 190         


Ile Leu His Ser Met His Arg Tyr Leu Pro Arg Leu His Leu Val Pro 
        195                 200                 205             


Ala Glu Lys Ala Val Glu Val Ile Gln Leu Asn Gly Pro Gly Val His 
    210                 215                 220                 


Thr Phe Thr Phe Pro Gln Thr Glu Phe Phe Ala Val Thr Ala Tyr Gln 
225                 230                 235                 240 


Asn Ile Gln Ile Thr Gln Leu Lys Ile Asp Tyr Asn Pro Phe Ala Lys 
                245                 250                 255     


Gly Phe Arg Asp Asp Gly Leu Asn Asn Lys Pro Gln Arg Asp Gly Lys 
            260                 265                 270         


Gln Lys Asn Ser Ser Asp Gln Glu Gly Asn Asn Ile Ser Ser Ser Ser 
        275                 280                 285             


Gly His Arg Val Arg Leu Thr Glu Gly Gln Gly Ser Glu Ile Gln Pro 
    290                 295                 300                 


Gly Asp Leu Asp Pro Leu Ser Arg Gly His Glu Thr Ser Gly Lys Gly 
305                 310                 315                 320 


Leu Glu Lys Thr Ser Leu Asn Ile Lys Arg Asp Phe Leu Gly Phe Met 
                325                 330                 335     


Asp Thr Asp Ser Ala Leu Ser Glu Val Pro Gln Leu Lys Gln Glu Ile 
            340                 345                 350         


Ser Glu Cys Leu Ile Ala Ser Ser Phe Glu Asp Asp Ser Arg Val Ala 
        355                 360                 365             


Ser Pro Leu Asp Gln Asn Gly Ser Phe Asn Val Val Ile Lys Glu Glu 
    370                 375                 380                 


Pro Leu Asp Asp Tyr Asp Tyr Glu Leu Gly Glu Cys Pro Glu Gly Val 
385                 390                 395                 400 


Thr Val Lys Gln Glu Glu Thr Asp Glu Glu Thr Asp Val Tyr Ser Asn 
                405                 410                 415     


Ser Asp Asp Asp Pro Ile Leu Glu Lys Gln Leu Lys Arg His Asn Lys 
            420                 425                 430         


Val Asp Asn Pro Glu Ala Asp His Leu Ser Ser Lys Trp Leu Pro Ser 
        435                 440                 445             


Ser Pro Ser Gly Val Ala Lys Ala Lys Met Phe Lys Leu Asp Thr Gly 
    450                 455                 460                 


Lys Met Pro Val Val Tyr Leu Glu Pro Cys Ala Val Thr Arg Ser Thr 
465                 470                 475                 480 


Val Lys Ile Ser Glu Leu Pro Asp Asn Met Leu Ser Thr Ser Arg Lys 
                485                 490                 495     


Asp Lys Ser Ser Met Leu Ala Glu Leu Glu Tyr Leu Pro Thr Tyr Ile 
            500                 505                 510         


Glu Asn Ser Asn Glu Thr Ala Phe Cys Leu Gly Lys Glu Ser Glu Asn 
        515                 520                 525             


Gly Leu Arg Lys His Ser Pro Asp Leu Arg Val Val Gln Lys Tyr Pro 
    530                 535                 540                 


Leu Leu Lys Glu Pro Gln Trp Lys Tyr Pro Asp Ile Ser Asp Ser Ile 
545                 550                 555                 560 


Ser Thr Glu Arg Ile Leu Asp Asp Ser Lys Asp Ser Val Gly Asp Ser 
                565                 570                 575     


Leu Ser Gly Lys Glu Asp Leu Gly Arg Lys Arg Thr Thr Met Leu Lys 
            580                 585                 590         


Ile Ala Thr Ala Ala Lys Val Val Asn Ala Asn Gln Asn Ala Ser Pro 
        595                 600                 605             


Asn Val Pro Gly Lys Arg Gly Arg Pro Arg Lys Leu Lys Leu Cys Lys 
    610                 615                 620                 


Ala Gly Arg Pro Pro Lys Asn Thr Gly Lys Ser Leu Ile Ser Thr Lys 
625                 630                 635                 640 


Asn Thr Pro Val Ser Pro Gly Ser Thr Phe Pro Asp Val Lys Pro Asp 
                645                 650                 655     


Leu Glu Asp Val Asp Gly Val Leu Phe Val Ser Phe Glu Ser Lys Glu 
            660                 665                 670         


Ala Leu Asp Ile His Ala Val Asp Gly Thr Thr Glu Glu Ser Ser Ser 
        675                 680                 685             


Leu Gln Ala Ser Thr Thr Asn Asp Ser Gly Tyr Arg Ala Arg Ile Ser 
    690                 695                 700                 


Gln Leu Glu Lys Glu Leu Ile Glu Asp Leu Lys Thr Leu Arg His Lys 
705                 710                 715                 720 


Gln Val Ile His Pro Gly Leu Gln Glu Val Gly Leu Lys Leu Asn Ser 
                725                 730                 735     


Val Asp Pro Thr Met Ser Ile Asp Leu Lys Tyr Leu Gly Val Gln Leu 
            740                 745                 750         


Pro Leu Ala Pro Ala Thr Ser Phe Pro Phe Trp Asn Leu Thr Gly Thr 
        755                 760                 765             


Asn Pro Ala Ser Pro Asp Ala Gly Phe Pro Phe Val Ser Arg Thr Gly 
    770                 775                 780                 


Lys Thr Asn Asp Phe Thr Lys Ile Lys Gly Trp Arg Gly Lys Phe His 
785                 790                 795                 800 


Ser Ala Ser Ala Ser Arg Asn Glu Gly Gly Asn Ser Glu Ser Ser Leu 
                805                 810                 815     


Lys Asn Arg Ser Ala Phe Cys Ser Asp Lys Leu Asp Glu Tyr Leu Glu 
            820                 825                 830         


Asn Glu Gly Lys Leu Met Glu Thr Ser Met Gly Phe Ser Ser Asn Ala 
        835                 840                 845             


Pro Thr Ser Pro Val Val Tyr Gln Leu Pro Thr Lys Ser Thr Ser Tyr 
    850                 855                 860                 


Val Arg Thr Leu Asp Ser Val Leu Lys Lys Gln Ser Thr Ile Ser Pro 
865                 870                 875                 880 


Ser Thr Ser Tyr Ser Leu Lys Pro His Ser Val Pro Pro Val Ser Arg 
                885                 890                 895     


Lys Ala Lys Ser Gln Asn Arg Gln Ala Thr Phe Ser Gly Arg Thr Lys 
            900                 905                 910         


Ser Ser Tyr Lys Ser Ile Leu Pro Tyr Pro Val Ser Pro Lys Gln Lys 
        915                 920                 925             


Tyr Ser His Val Ile Leu Gly Asp Lys Val Thr Lys Asn Ser Ser Gly 
    930                 935                 940                 


Ile Ile Ser Glu Asn Gln Ala Asn Asn Phe Val Val Pro Thr Leu Asp 
945                 950                 955                 960 


Glu Asn Ile Phe Pro Lys Gln Ile Ser Leu Arg Gln Ala Gln Gln Gln 
                965                 970                 975     


Gln Gln Gln Gln Gln Gly Ser Arg Pro Pro Gly Leu Ser Lys Ser Gln 
            980                 985                 990         


Val Lys Leu Met Asp Leu Glu Asp  Cys Ala Leu Trp Glu  Gly Lys Pro 
        995                 1000                 1005             


Arg Thr  Tyr Ile Thr Glu Glu  Arg Ala Asp Val Ser  Leu Thr Thr 
    1010                 1015                 1020             


Leu Leu  Thr Ala Gln Ala Ser  Leu Lys Thr Lys Pro  Ile His Thr 
    1025                 1030                 1035             


Ile Ile  Arg Lys Arg Ala Pro  Pro Cys Asn Asn Asp  Phe Cys Arg 
    1040                 1045                 1050             


Leu Gly  Cys Val Cys Ser Ser  Leu Ala Leu Glu Lys  Arg Gln Pro 
    1055                 1060                 1065             


Ala His  Cys Arg Arg Pro Asp  Cys Met Phe Gly Cys  Thr Cys Leu 
    1070                 1075                 1080             


Lys Arg  Lys Val Val Leu Val  Lys Gly Gly Ser Lys  Thr Lys His 
    1085                 1090                 1095             


Phe Gln  Arg Lys Ala Ala His  Arg Asp Pro Val Phe  Tyr Asp Thr 
    1100                 1105                 1110             


Leu Gly  Glu Glu Ala Arg Glu  Glu Glu Glu Gly Ile  Arg Glu Glu 
    1115                 1120                 1125             


Glu Glu  Gln Leu Lys Glu Lys  Lys Lys Arg Lys Lys  Leu Glu Tyr 
    1130                 1135                 1140             


Thr Ile  Cys Glu Thr Glu Pro  Glu Gln Pro Val Arg  His Tyr Pro 
    1145                 1150                 1155             


Leu Trp  Val Lys Val Glu Gly  Glu Val Asp Pro Glu  Pro Val Tyr 
    1160                 1165                 1170             


Ile Pro  Thr Pro Ser Val Ile  Glu Pro Met Lys Pro  Leu Leu Leu 
    1175                 1180                 1185             


Pro Gln  Pro Glu Val Leu Ser  Pro Thr Val Lys Gly  Lys Leu Leu 
    1190                 1195                 1200             


Thr Gly  Ile Lys Ser Pro Arg  Ser Tyr Thr Pro Lys  Pro Asn Pro 
    1205                 1210                 1215             


Val Ile  Arg Glu Glu Asp Lys  Asp Pro Val Tyr Leu  Tyr Phe Glu 
    1220                 1225                 1230             


Ser Met  Met Thr Cys Ala Arg  Val Arg Val Tyr Glu  Arg Lys Lys 
    1235                 1240                 1245             


Glu Asp  Gln Arg Gln Pro Ser  Ser Ser Ser Ser Pro  Ser Pro Ser 
    1250                 1255                 1260             


Phe Gln  Gln Gln Thr Ser Cys  His Ser Ser Pro Glu  Asn His Asn 
    1265                 1270                 1275             


Asn Ala  Lys Glu Pro Asp Ser  Glu Gln Gln Pro Leu  Lys Gln Leu 
    1280                 1285                 1290             


Thr Cys  Asp Leu Glu Asp Asp  Ser Asp Lys Leu Gln  Glu Lys Ser 
    1295                 1300                 1305             


Trp Lys  Ser Ser Cys Asn Glu  Gly Glu Ser Ser Ser  Thr Ser Tyr 
    1310                 1315                 1320             


Met His  Gln Arg Ser Pro Gly  Gly Pro Thr Lys Leu  Ile Glu Ile 
    1325                 1330                 1335             


Ile Ser  Asp Cys Asn Trp Glu  Glu Asp Arg Asn Lys  Ile Leu Ser 
    1340                 1345                 1350             


Ile Leu  Ser Gln His Ile Asn  Ser Asn Met Pro Gln  Ser Leu Lys 
    1355                 1360                 1365             


Val Gly  Ser Phe Ile Ile Glu  Leu Ala Ser Gln Arg  Lys Ser Arg 
    1370                 1375                 1380             


Gly Glu  Lys Asn Pro Pro Val  Tyr Ser Ser Arg Val  Lys Ile Ser 
    1385                 1390                 1395             


Met Pro  Ser Cys Gln Asp Gln  Asp Asp Met Ala Glu  Lys Ser Gly 
    1400                 1405                 1410             


Ser Glu  Thr Pro Asp Gly Pro  Leu Ser Pro Gly Lys  Met Glu Asp 
    1415                 1420                 1425             


Ile Ser  Pro Val Gln Thr Asp  Ala Leu Asp Ser Val  Arg Glu Arg 
    1430                 1435                 1440             


Leu His  Gly Gly Lys Gly Leu  Pro Phe Tyr Ala Gly  Leu Ser Pro 
    1445                 1450                 1455             


Ala Gly  Lys Leu Val Ala Tyr  Lys Arg Lys Pro Ser  Ser Ser Thr 
    1460                 1465                 1470             


Ser Gly  Leu Ile Gln Val Ala  Ser Asn Ala Lys Val  Ala Ala Ser 
    1475                 1480                 1485             


Arg Lys  Pro Arg Thr Leu Leu  Pro Ser Thr Ser Asn  Ser Lys Met 
    1490                 1495                 1500             


Ala Ser  Ser Ser Gly Thr Ala  Thr Asn Arg Pro Gly  Lys Asn Leu 
    1505                 1510                 1515             


Lys Ala  Phe Val Pro Ala Lys  Arg Pro Ile Glu Asn  Ala Ala Gln 
    1520                 1525                 1530             


Ile Pro  Val Ala Thr Pro Gln  Val Ser Pro Asn Thr  Val Lys Arg 
    1535                 1540                 1545             


Ala Gly  Pro Arg Leu Leu Leu  Ile Pro Val Gln Gln  Gly Ser Pro 
    1550                 1555                 1560             


Thr Leu  Arg Pro Val Ser Asn  Thr Gln Leu Gln Gly  His Arg Met 
    1565                 1570                 1575             


Val Leu  Gln Pro Val Arg Ser  Pro Ser Gly Met Asn  Leu Phe Arg 
    1580                 1585                 1590             


His Pro  Asn Gly Gln Ile Val  Gln Leu Leu Pro Leu  His Gln Leu 
    1595                 1600                 1605             


Arg Gly  Ser Asn Thr Gln Pro  Asn Leu Gln Pro Val  Met Phe Arg 
    1610                 1615                 1620             


Asn Pro  Gly Ser Val Met Gly  Ile Arg Leu Pro Ala  Pro Ser Lys 
    1625                 1630                 1635             


Pro Ser  Glu Thr Pro Pro Ser  Ser Thr Ser Ser Ser  Ala Phe Ser 
    1640                 1645                 1650             


Val Met  Asn Pro Val Ile Gln  Ala Val Gly Ser Ser  Ser Ala Val 
    1655                 1660                 1665             


Asn Val  Ile Thr Gln Ala Pro  Ser Leu Leu Ser Ser  Gly Ala Ser 
    1670                 1675                 1680             


Phe Val  Ser Gln Ala Gly Thr  Leu Thr Leu Arg Ile  Ser Pro Pro 
    1685                 1690                 1695             


Glu Pro  Gln Ser Phe Ala Ser  Lys Thr Gly Ser Glu  Thr Lys Ile 
    1700                 1705                 1710             


Thr Tyr  Ser Ser Gly Gly Gln  Pro Val Gly Thr Ala  Ser Leu Ile 
    1715                 1720                 1725             


Pro Leu  Gln Ser Gly Ser Phe  Ala Leu Leu Gln Leu  Pro Gly Gln 
    1730                 1735                 1740             


Lys Pro  Val Pro Ser Ser Ile  Leu Gln His Val Ala  Ser Leu Gln 
    1745                 1750                 1755             


Met Lys  Arg Glu Ser Gln Asn  Pro Asp Gln Lys Asp  Glu Thr Asn 
    1760                 1765                 1770             


Ser Ile  Lys Arg Glu Gln Glu  Thr Lys Lys Val Leu  Gln Ser Glu 
    1775                 1780                 1785             


Gly Glu  Ala Val Asp Pro Glu  Ala Asn Val Ile Lys  Gln Asn Ser 
    1790                 1795                 1800             


Gly Ala  Ala Thr Ser Glu Glu  Thr Leu Asn Asp Ser  Leu Glu Asp 
    1805                 1810                 1815             


Arg Gly  Asp His Leu Asp Glu  Glu Cys Leu Pro Glu  Glu Gly Cys 
    1820                 1825                 1830             


Ala Thr  Val Lys Pro Ser Glu  His Ser Cys Ile Thr  Gly Ser His 
    1835                 1840                 1845             


Thr Asp  Gln Asp Tyr Lys Asp  Val Asn Glu Glu Tyr  Gly Ala Arg 
    1850                 1855                 1860             


Asn Arg  Lys Ser Ser Lys Glu  Lys Val Ala Val Leu  Glu Val Arg 
    1865                 1870                 1875             


Thr Ile  Ser Glu Lys Ala Ser  Asn Lys Thr Val Gln  Asn Leu Ser 
    1880                 1885                 1890             


Lys Val  Gln His Gln Lys Leu  Gly Asp Val Lys Val  Glu Gln Gln 
    1895                 1900                 1905             


Lys Gly  Phe Asp Asn Pro Glu  Glu Asn Ser Ser Glu  Phe Pro Val 
    1910                 1915                 1920             


Thr Phe  Lys Glu Glu Ser Lys  Phe Glu Leu Ser Gly  Ser Lys Val 
    1925                 1930                 1935             


Met Glu  Gln Gln Ser Asn Leu  Gln Pro Glu Ala Lys  Glu Lys Glu 
    1940                 1945                 1950             


Cys Gly  Asp Ser Leu Glu Lys  Asp Arg Glu Arg Trp  Arg Lys His 
    1955                 1960                 1965             


Leu Lys  Gly Pro Leu Thr Arg  Lys Cys Val Gly Ala  Ser Gln Glu 
    1970                 1975                 1980             


Cys Lys  Lys Glu Ala Asp Glu  Gln Leu Ile Lys Glu  Thr Lys Thr 
    1985                 1990                 1995             


Cys Gln  Glu Asn Ser Asp Val  Phe Gln Gln Glu Gln  Gly Ile Ser 
    2000                 2005                 2010             


Asp Leu  Leu Gly Lys Ser Gly  Ile Thr Glu Asp Ala  Arg Val Leu 
    2015                 2020                 2025             


Lys Thr  Glu Cys Asp Ser Trp  Ser Arg Ile Ser Asn  Pro Ser Ala 
    2030                 2035                 2040             


Phe Ser  Ile Val Pro Arg Arg  Ala Ala Lys Ser Ser  Arg Gly Asn 
    2045                 2050                 2055             


Gly His  Phe Gln Gly His Leu  Leu Leu Pro Gly Glu  Gln Ile Gln 
    2060                 2065                 2070             


Pro Lys  Gln Glu Lys Lys Gly  Gly Arg Ser Ser Ala  Asp Phe Thr 
    2075                 2080                 2085             


Val Leu  Asp Leu Glu Glu Asp  Asp Glu Asp Asp Asn  Glu Lys Thr 
    2090                 2095                 2100             


Asp Asp  Ser Ile Asp Glu Ile  Val Asp Val Val Ser  Asp Tyr Gln 
    2105                 2110                 2115             


Ser Glu  Glu Val Asp Asp Val  Glu Lys Asn Asn Cys  Val Glu Tyr 
    2120                 2125                 2130             


Ile Glu  Asp Asp Glu Glu His  Val Asp Ile Glu Thr  Val Glu Glu 
    2135                 2140                 2145             


Leu Ser  Glu Glu Ile Asn Val  Ala His Leu Lys Thr  Thr Ala Ala 
    2150                 2155                 2160             


His Thr  Gln Ser Phe Lys Gln  Pro Ser Cys Thr His  Ile Ser Ala 
    2165                 2170                 2175             


Asp Glu  Lys Ala Ala Glu Arg  Ser Arg Lys Ala Pro  Pro Ile Pro 
    2180                 2185                 2190             


Leu Lys  Leu Lys Pro Asp Tyr  Trp Ser Asp Lys Leu  Gln Lys Glu 
    2195                 2200                 2205             


Ala Glu  Ala Phe Ala Tyr Tyr  Arg Arg Thr His Thr  Ala Asn Glu 
    2210                 2215                 2220             


Arg Arg  Arg Arg Gly Glu Met  Arg Asp Leu Phe Glu  Lys Leu Lys 
    2225                 2230                 2235             


Ile Thr  Leu Gly Leu Leu His  Ser Ser Lys Val Ser  Lys Ser Leu 
    2240                 2245                 2250             


Ile Leu  Thr Arg Ala Phe Ser  Glu Ile Gln Gly Leu  Thr Asp Gln 
    2255                 2260                 2265             


Ala Asp  Lys Leu Ile Gly Gln  Lys Asn Leu Leu Thr  Arg Lys Arg 
    2270                 2275                 2280             


Asn Ile  Leu Ile Arg Lys Val  Ser Ser Leu Ser Gly  Lys Thr Glu 
    2285                 2290                 2295             


Glu Val  Val Leu Lys Lys Leu  Glu Tyr Ile Tyr Ala  Lys Gln Gln 
    2300                 2305                 2310             


Ala Leu  Glu Ala Gln Lys Arg  Lys Lys Lys Met Gly  Ser Asp Glu 
    2315                 2320                 2325             


Phe Asp  Ile Ser Pro Arg Ile  Ser Lys Gln Gln Glu  Gly Ser Ser 
    2330                 2335                 2340             


Ala Ser  Ser Val Asp Leu Gly  Gln Met Phe Ile Asn  Asn Arg Arg 
    2345                 2350                 2355             


Gly Lys  Pro Leu Ile Leu Ser  Arg Lys Lys Asp Gln  Ala Thr Glu 
    2360                 2365                 2370             


Asn Thr  Ser Pro Leu Asn Thr  Pro His Thr Ser Ala  Asn Leu Val 
    2375                 2380                 2385             


Met Thr  Pro Gln Gly Gln Leu  Leu Thr Leu Lys Gly  Pro Leu Phe 
    2390                 2395                 2400             


Ser Gly  Pro Val Val Ala Val  Ser Pro Asp Leu Leu  Glu Ser Asp 
    2405                 2410                 2415             


Leu Lys  Pro Gln Val Ala Gly  Ser Ala Val Ala Leu  Pro Glu Asn 
    2420                 2425                 2430             


Asp Asp  Leu Phe Met Met Pro  Arg Ile Val Asn Val  Thr Ser Leu 
    2435                 2440                 2445             


Ala Thr  Glu Gly Gly Leu Val  Asp Met Gly Gly Ser  Lys Tyr Pro 
    2450                 2455                 2460             


His Glu  Val Pro Asp Ser Lys  Pro Ser Asp His Leu  Lys Asp Thr 
    2465                 2470                 2475             


Val Arg  Asn Glu Asp Asn Ser  Leu Glu Asp Lys Gly  Arg Ile Ser 
    2480                 2485                 2490             


Ser Arg  Gly Asn Arg Asp Gly  Arg Val Thr Leu Gly  Pro Thr Gln 
    2495                 2500                 2505             


Val Phe  Leu Ala Asn Lys Asp  Ser Gly Tyr Pro Gln  Ile Val Asp 
    2510                 2515                 2520             


Val Ser  Asn Met Gln Lys Ala  Gln Glu Phe Leu Pro  Lys Lys Ile 
    2525                 2530                 2535             


Ser Gly  Asp Met Arg Gly Ile  Gln Tyr Lys Trp Lys  Glu Ser Glu 
    2540                 2545                 2550             


Ser Arg  Gly Glu Arg Val Lys  Ser Lys Asp Ser Ser  Phe His Lys 
    2555                 2560                 2565             


Leu Lys  Met Lys Asp Leu Lys  Asp Ser Ser Ile Glu  Met Glu Leu 
    2570                 2575                 2580             


Arg Lys  Val Thr Ser Ala Ile  Glu Glu Ala Ala Leu  Asp Ser Ser 
    2585                 2590                 2595             


Glu Leu  Leu Thr Asn Met Glu  Asp Glu Asp Asp Thr  Asp Glu Thr 
    2600                 2605                 2610             


Leu Thr  Ser Leu Leu Asn Glu  Ile Ala Phe Leu Asn  Gln Gln Leu 
    2615                 2620                 2625             


Asn Asp  Asp Ser Val Gly Leu  Ala Glu Leu Pro Ser  Ser Met Asp 
    2630                 2635                 2640             


Thr Glu  Phe Pro Gly Asp Ala  Arg Arg Ala Phe Ile  Ser Lys Val 
    2645                 2650                 2655             


Pro Pro  Gly Ser Arg Ala Thr  Phe Gln Val Glu His  Leu Gly Thr 
    2660                 2665                 2670             


Gly Leu  Lys Glu Leu Pro Asp  Val Gln Gly Glu Ser  Asp Ser Ile 
    2675                 2680                 2685             


Ser Pro  Leu Leu Leu His Leu  Glu Asp Asp Asp Phe  Ser Glu Asn 
    2690                 2695                 2700             


Glu Lys  Gln Leu Ala Glu Pro  Ala Ser Glu Pro Asp  Val Leu Lys 
    2705                 2710                 2715             


Ile Val  Ile Asp Ser Glu Ile  Lys Asp Ser Leu Leu  Ser Asn Lys 
    2720                 2725                 2730             


Lys Ala  Ile Asp Gly Gly Lys  Asn Thr Ser Gly Leu  Pro Ala Glu 
    2735                 2740                 2745             


Pro Glu  Ser Val Ser Ser Pro  Pro Thr Leu His Met  Lys Thr Gly 
    2750                 2755                 2760             


Leu Glu  Asn Ser Asn Ser Thr  Asp Thr Leu Trp Arg  Pro Met Pro 
    2765                 2770                 2775             


Lys Leu  Ala Pro Leu Gly Leu  Lys Val Ala Asn Pro  Ser Ser Asp 
    2780                 2785                 2790             


Ala Asp  Gly Gln Ser Leu Lys  Val Met Pro Cys Leu  Ala Pro Ile 
    2795                 2800                 2805             


Ala Ala  Lys Val Gly Ser Val  Gly His Lys Met Asn  Leu Thr Gly 
    2810                 2815                 2820             


Asn Asp  Gln Glu Gly Arg Glu  Ser Lys Val Met Pro  Thr Leu Ala 
    2825                 2830                 2835             


Pro Val  Val Ala Lys Leu Gly  Asn Ser Gly Ala Ser  Pro Ser Ser 
    2840                 2845                 2850             


Ala Gly  Lys 
    2855     


<210>  8657
<211>  61
<212>  PRT
<213>  Homo Sapiens

<400>  8657

Met Lys Phe Leu Phe Leu Phe Phe Leu Arg Gln Ser Leu Thr Leu Ser 
1               5                   10                  15      


Pro Arg Leu Glu Cys Ser Gly Ala Val Leu Ala His Cys Lys Leu Cys 
            20                  25                  30          


Leu Pro Gly Leu Arg His Cys Pro Ala Pro Ala Thr Arg Glu Ala Glu 
        35                  40                  45              


Ala Arg Glu Trp Leu Glu Thr Arg Ser Arg Arg Leu Gln 
    50                  55                  60      


<210>  8658
<211>  83
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8658

Xaa Asp Gln Glu Gly Asn Asn Ile Ser Ser Ser Ser Gly His Arg Val 
1               5                   10                  15      


Arg Leu Thr Glu Gly Gln Gly Ser Glu Ile Gln Pro Gly Asp Leu Asp 
            20                  25                  30          


Pro Leu Ser Arg Gly His Glu Thr Ser Gly Lys Gly Leu Glu Lys Thr 
        35                  40                  45              


Ser Leu Asn Ile Lys Arg Asp Phe Leu Gly Phe Met Asp Thr Asp Ser 
    50                  55                  60                  


Ala Leu Ser Glu Val Pro Gln Leu Lys Gln Glu Ile Ser Glu Trp Tyr 
65                  70                  75                  80  


Ser Phe Ala 
            


<210>  8659
<211>  1174
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8659

Xaa Leu Thr Cys Asp Leu Glu Asp Asp Ser Asp Lys Leu Gln Glu Lys 
1               5                   10                  15      


Ser Trp Lys Ser Ser Cys Asn Glu Gly Glu Ser Ser Ser Thr Ser Tyr 
            20                  25                  30          


Met His Gln Arg Ser Pro Gly Gly Pro Thr Lys Leu Ile Glu Ile Ile 
        35                  40                  45              


Ser Asp Cys Asn Trp Glu Glu Asp Arg Asn Lys Ile Leu Ser Ile Leu 
    50                  55                  60                  


Ser Gln His Ile Asn Ser Asn Met Pro Gln Ser Leu Lys Val Asn Gly 
65                  70                  75                  80  


Lys Ser Tyr Pro Gln Ala Lys Leu Leu Leu Gly Gln Met Gly Ala Leu 
                85                  90                  95      


His Pro Ala Asn Arg Leu Ala Ala Tyr Ile Thr Gly Arg Leu Arg Pro 
            100                 105                 110         


Ser Val Leu Asp Leu Ser Thr Leu Ser Thr Val Ile Ser Lys Val Ala 
        115                 120                 125             


Ser Asn Ala Lys Val Ala Ala Ser Arg Lys Pro Arg Thr Leu Leu Pro 
    130                 135                 140                 


Ser Thr Ser Asn Ser Lys Met Ala Ser Ser Ser Gly Thr Ala Thr Asn 
145                 150                 155                 160 


Arg Pro Gly Lys Asn Leu Lys Ala Phe Val Pro Ala Lys Arg Pro Ile 
                165                 170                 175     


Ala Ala Arg Pro Ser Pro Gly Gly Val Phe Thr Gln Phe Val Met Ser 
            180                 185                 190         


Lys Val Gly Ala Leu Gln Gln Lys Ile Pro Gly Val Ser Thr Pro Gln 
        195                 200                 205             


Thr Leu Ala Gly Thr Gln Lys Phe Ser Ile Arg Pro Ser Pro Val Met 
    210                 215                 220                 


Val Val Thr Pro Val Val Ser Ser Glu Pro Val Gln Val Cys Ser Pro 
225                 230                 235                 240 


Val Thr Ala Ala Val Thr Thr Thr Thr Pro Gln Val Phe Leu Glu Asn 
                245                 250                 255     


Thr Thr Ala Val Thr Pro Met Thr Ala Ile Ser Asp Val Glu Thr Lys 
            260                 265                 270         


Glu Thr Thr Tyr Ser Ser Gly Ala Thr Thr Thr Gly Val Val Glu Val 
        275                 280                 285             


Ser Glu Thr Asn Thr Ser Thr Ser Val Thr Ser Thr Gln Ser Thr Ala 
    290                 295                 300                 


Thr Val Asn Leu Thr Lys Thr Thr Gly Ile Thr Thr Pro Val Ala Ser 
305                 310                 315                 320 


Val Ala Phe Pro Lys Ser Leu Val Ala Ser Pro Ser Thr Ile Thr Leu 
                325                 330                 335     


Pro Val Ala Ser Thr Ala Ser Thr Ser Leu Val Val Val Thr Ala Ala 
            340                 345                 350         


Ala Ser Ser Ser Met Val Thr Thr Pro Thr Ser Ser Leu Gly Ser Val 
        355                 360                 365             


Pro Ile Ile Leu Ser Gly Ile Asn Gly Ser Pro Pro Val Ser Gln Arg 
    370                 375                 380                 


Pro Glu Asn Ala Ala Gln Ile Pro Val Ala Thr Pro Gln Val Ser Pro 
385                 390                 395                 400 


Asn Thr Val Lys Arg Ala Gly Pro Arg Leu Leu Leu Ile Pro Val Gln 
                405                 410                 415     


Gln Gly Ser Pro Thr Leu Arg Pro Val Ser Asn Thr Gln Leu Gln Gly 
            420                 425                 430         


His Arg Met Val Leu Gln Pro Val Arg Ser Pro Ser Gly Met Asn Leu 
        435                 440                 445             


Phe Arg His Pro Asn Gly Gln Ile Val Gln Leu Leu Pro Leu His Gln 
    450                 455                 460                 


Leu Arg Gly Ser Asn Thr Gln Pro Asn Leu Gln Pro Val Met Phe Arg 
465                 470                 475                 480 


Asn Pro Gly Ser Val Met Gly Ile Arg Leu Pro Ala Pro Ser Lys Pro 
                485                 490                 495     


Ser Glu Thr Pro Pro Ser Ser Thr Ser Ser Ser Ala Phe Ser Val Met 
            500                 505                 510         


Asn Pro Val Ile Gln Ala Val Gly Ser Ser Ser Ala Val Asn Val Ile 
        515                 520                 525             


Thr Gln Ala Pro Ser Leu Leu Ser Ser Gly Ala Ser Phe Val Ser Gln 
    530                 535                 540                 


Ala Gly Thr Leu Thr Leu Arg Ile Ser Pro Pro Glu Pro Gln Ser Phe 
545                 550                 555                 560 


Ala Ser Lys Thr Gly Ser Glu Thr Lys Ile Thr Tyr Ser Ser Gly Gly 
                565                 570                 575     


Gln Pro Val Gly Thr Ala Ser Leu Ile Pro Leu Gln Ser Gly Ser Phe 
            580                 585                 590         


Ala Leu Leu Gln Leu Pro Gly Gln Lys Pro Val Pro Ser Ser Ile Leu 
        595                 600                 605             


Gln His Val Ala Ser Leu Gln Met Lys Arg Glu Ser Gln Asn Pro Asp 
    610                 615                 620                 


Gln Lys Asp Glu Thr Asn Ser Ile Lys Arg Glu Gln Glu Thr Lys Lys 
625                 630                 635                 640 


Val Leu Gln Ser Glu Gly Glu Ala Val Asp Pro Glu Ala Asn Val Ile 
                645                 650                 655     


Lys Gln Asn Ser Gly Ala Ala Thr Ser Glu Glu Thr Leu Asn Asp Ser 
            660                 665                 670         


Leu Glu Asp Arg Gly Asp His Leu Asp Glu Glu Cys Leu Pro Glu Glu 
        675                 680                 685             


Gly Cys Ala Thr Val Lys Pro Ser Glu His Ser Cys Ile Thr Gly Ser 
    690                 695                 700                 


His Thr Asp Gln Asp Tyr Lys Asp Val Asn Glu Glu Tyr Gly Ala Arg 
705                 710                 715                 720 


Asn Arg Lys Ser Ser Lys Glu Lys Val Ala Val Leu Glu Val Arg Thr 
                725                 730                 735     


Ile Ser Glu Lys Ala Ser Asn Lys Thr Val Gln Asn Leu Ser Lys Val 
            740                 745                 750         


Gln His Gln Lys Leu Gly Asp Val Lys Val Glu Gln Gln Lys Gly Phe 
        755                 760                 765             


Asp Asn Pro Glu Glu Asn Ser Ser Glu Phe Pro Val Thr Phe Lys Glu 
    770                 775                 780                 


Glu Ser Lys Phe Glu Leu Ser Gly Ser Lys Val Met Glu Gln Gln Ser 
785                 790                 795                 800 


Asn Leu Gln Pro Glu Ala Lys Glu Lys Glu Cys Gly Asp Ser Leu Glu 
                805                 810                 815     


Lys Asp Arg Glu Arg Trp Arg Lys His Leu Lys Gly Pro Leu Thr Arg 
            820                 825                 830         


Lys Cys Val Gly Ala Ser Gln Glu Cys Lys Lys Glu Ala Asp Glu Gln 
        835                 840                 845             


Leu Ile Lys Glu Thr Lys Thr Cys Gln Glu Asn Ser Asp Val Phe Gln 
    850                 855                 860                 


Gln Glu Gln Gly Ile Ser Asp Leu Leu Gly Lys Ser Gly Ile Thr Glu 
865                 870                 875                 880 


Asp Ala Arg Val Leu Lys Thr Glu Cys Asp Ser Trp Ser Arg Ile Ser 
                885                 890                 895     


Asn Pro Ser Ala Phe Ser Ile Val Pro Arg Arg Ala Ala Lys Ser Ser 
            900                 905                 910         


Arg Gly Asn Gly His Phe Gln Gly His Leu Leu Leu Pro Gly Glu Gln 
        915                 920                 925             


Ile Gln Pro Lys Gln Glu Lys Lys Gly Gly Arg Ser Ser Ala Asp Phe 
    930                 935                 940                 


Thr Val Leu Asp Leu Glu Glu Asp Asp Glu Asp Asp Asn Glu Lys Thr 
945                 950                 955                 960 


Asp Asp Ser Ile Asp Glu Ile Val Asp Val Val Ser Asp Tyr Gln Ser 
                965                 970                 975     


Glu Glu Val Asp Asp Val Glu Lys Asn Asn Cys Val Glu Tyr Ile Glu 
            980                 985                 990         


Asp Asp Glu Glu His Val Asp Ile  Glu Thr Val Glu Glu  Leu Ser Glu 
        995                 1000                 1005             


Glu Ile  Asn Val Ala His Leu  Lys Thr Thr Ala Ala  His Thr Gln 
    1010                 1015                 1020             


Ser Phe  Lys Gln Pro Ser Cys  Thr His Ile Ser Ala  Asp Glu Lys 
    1025                 1030                 1035             


Ala Ala  Glu Arg Ser Arg Lys  Ala Pro Pro Ile Pro  Leu Lys Leu 
    1040                 1045                 1050             


Lys Pro  Asp Tyr Trp Ser Asp  Lys Leu Gln Lys Glu  Ala Glu Ala 
    1055                 1060                 1065             


Phe Ala  Tyr Tyr Arg Arg Thr  His Thr Ala Asn Glu  Arg Arg Arg 
    1070                 1075                 1080             


Arg Gly  Glu Met Arg Asp Leu  Phe Glu Lys Leu Lys  Ile Thr Leu 
    1085                 1090                 1095             


Gly Leu  Leu His Ser Ser Lys  Val Ser Lys Ser Leu  Ile Leu Thr 
    1100                 1105                 1110             


Arg Ala  Phe Ser Glu Ile Gln  Gly Leu Thr Asp Gln  Ala Asp Lys 
    1115                 1120                 1125             


Leu Ile  Gly Gln Lys Asn Leu  Leu Thr Arg Lys Arg  Asn Ile Leu 
    1130                 1135                 1140             


Ile Arg  Lys Val Ser Ser Leu  Ser Gly Lys Thr Glu  Glu Val Val 
    1145                 1150                 1155             


Leu Lys  Lys Leu Glu Tyr Ile  Tyr Ala Lys Gln Gln  Ala Leu Glu 
    1160                 1165                 1170             


Ala 
    


<210>  8660
<211>  447
<212>  PRT
<213>  Homo Sapiens

<400>  8660

Met Arg Phe Arg Ile Tyr Lys Arg Lys Val Leu Ile Leu Thr Leu Val 
1               5                   10                  15      


Val Ala Ala Cys Gly Phe Val Leu Trp Ser Ser Asn Gly Arg Gln Arg 
            20                  25                  30          


Lys Asn Glu Ala Leu Ala Pro Pro Leu Leu Asp Ala Glu Pro Ala Arg 
        35                  40                  45              


Gly Ala Gly Gly Arg Gly Gly Asp His Pro Ser Val Ala Val Gly Ile 
    50                  55                  60                  


Arg Arg Val Ser Asn Val Ser Ala Ala Ser Leu Val Pro Ala Val Pro 
65                  70                  75                  80  


Gln Pro Glu Ala Asp Asn Leu Thr Leu Arg Tyr Arg Ser Leu Val Tyr 
                85                  90                  95      


Gln Leu Asn Phe Asp Gln Thr Leu Arg Asn Val Asp Lys Ala Gly Thr 
            100                 105                 110         


Trp Ala Pro Arg Glu Leu Val Leu Val Val Gln Val His Asn Arg Pro 
        115                 120                 125             


Glu Tyr Leu Arg Leu Leu Leu Asp Ser Leu Arg Lys Ala Gln Gly Ile 
    130                 135                 140                 


Asp Asn Val Leu Val Ile Phe Ser His Asp Phe Trp Ser Thr Glu Ile 
145                 150                 155                 160 


Asn Gln Leu Ile Ala Gly Val Asn Phe Cys Pro Val Leu Gln Val Phe 
                165                 170                 175     


Phe Pro Phe Ser Ile Gln Leu Tyr Pro Asn Glu Phe Pro Gly Ser Asp 
            180                 185                 190         


Pro Arg Asp Cys Pro Arg Asp Leu Pro Lys Asn Ala Ala Leu Lys Leu 
        195                 200                 205             


Gly Cys Ile Asn Ala Glu Tyr Pro Asp Ser Phe Gly His Tyr Arg Glu 
    210                 215                 220                 


Ala Lys Phe Ser Gln Thr Lys His His Trp Trp Trp Lys Leu His Phe 
225                 230                 235                 240 


Val Trp Glu Arg Val Lys Ile Leu Arg Asp Tyr Ala Gly Leu Ile Leu 
                245                 250                 255     


Phe Leu Glu Glu Asp His Tyr Leu Ala Pro Asp Phe Tyr His Val Phe 
            260                 265                 270         


Lys Lys Met Trp Lys Leu Lys Gln Gln Glu Cys Pro Glu Cys Asp Val 
        275                 280                 285             


Leu Ser Leu Gly Thr Tyr Ser Ala Ser Arg Ser Phe Tyr Gly Met Ala 
    290                 295                 300                 


Asp Lys Val Asp Val Lys Thr Trp Lys Ser Thr Glu His Asn Met Gly 
305                 310                 315                 320 


Leu Ala Leu Thr Arg Asn Ala Tyr Gln Lys Leu Ile Glu Cys Thr Asp 
                325                 330                 335     


Thr Phe Cys Thr Tyr Asp Asp Tyr Asn Trp Asp Trp Thr Leu Gln Tyr 
            340                 345                 350         


Leu Thr Val Ser Cys Leu Pro Lys Phe Trp Lys Val Leu Val Pro Gln 
        355                 360                 365             


Ile Pro Arg Ile Phe His Ala Gly Asp Cys Gly Met His His Lys Lys 
    370                 375                 380                 


Thr Cys Arg Pro Ser Thr Gln Ser Ala Gln Ile Glu Ser Leu Leu Asn 
385                 390                 395                 400 


Asn Asn Lys Gln Tyr Met Phe Pro Glu Thr Leu Thr Ile Ser Glu Lys 
                405                 410                 415     


Phe Thr Val Val Ala Ile Ser Pro Pro Arg Lys Asn Gly Gly Trp Gly 
            420                 425                 430         


Asp Ile Arg Asp His Glu Leu Cys Lys Ser Tyr Arg Arg Leu Gln 
        435                 440                 445         


<210>  8661
<211>  108
<212>  PRT
<213>  Homo Sapiens

<400>  8661

Met Glu Ser Cys Ser Cys His Pro Gly Ser Gly Val Gln Trp Arg Asp 
1               5                   10                  15      


His Gly Ser Leu Gln Leu Pro Pro Pro Gly Phe Lys Met Lys Met Arg 
            20                  25                  30          


Arg Tyr Lys Leu Phe Leu Met Phe Cys Met Ala Gly Leu Cys Leu Ile 
        35                  40                  45              


Ser Phe Leu His Phe Phe Lys Thr Leu Ser Tyr Val Thr Phe Pro Arg 
    50                  55                  60                  


Glu Leu Ala Ser Leu Ser Pro Asn Leu Val Ser Ser Phe Phe Trp Asn 
65                  70                  75                  80  


Asn Ala Pro Val Thr Pro Gln Ala Ser Pro Glu Pro Gly Gly Pro Asp 
                85                  90                  95      


Leu Leu Arg Thr Pro Leu Tyr Ser His Ser Pro Leu 
            100                 105             


<210>  8662
<211>  161
<212>  PRT
<213>  Homo Sapiens

<400>  8662

Met Lys Met Arg Arg Tyr Lys Leu Phe Leu Met Phe Cys Met Ala Gly 
1               5                   10                  15      


Leu Cys Leu Ile Ser Phe Leu His Phe Phe Lys Thr Leu Ser Tyr Val 
            20                  25                  30          


Thr Phe Pro Arg Glu Leu Ala Ser Leu Ser Pro Asn Leu Val Ser Ser 
        35                  40                  45              


Phe Phe Trp Asn Asn Ala Pro Val Thr Pro Gln Ala Ser Pro Glu Pro 
    50                  55                  60                  


Gly Gly Pro Asp Leu Leu Arg Thr Pro Leu Tyr Ser His Ser Pro Leu 
65                  70                  75                  80  


Leu Gln Pro Leu Pro Pro Ser Lys Ala Ala Glu Glu Leu His Arg Val 
                85                  90                  95      


Asp Leu Val Leu Pro Glu Asp Thr Thr Glu Tyr Phe Val Arg Thr Lys 
            100                 105                 110         


Ala Gly Gly Val Cys Phe Lys Pro Gly Thr Lys Met Leu Glu Arg Pro 
        115                 120                 125             


Pro Pro Gly Arg Pro Glu Glu Lys Pro Glu Gly Ala Asn Gly Ser Ser 
    130                 135                 140                 


Ala Arg Arg Pro Pro Arg Tyr Leu Leu Ser Ala Arg Glu Arg Thr Gly 
145                 150                 155                 160 


Gly 
    


<210>  8663
<211>  533
<212>  PRT
<213>  Homo Sapiens

<400>  8663

Met Lys Met Arg Arg Tyr Lys Leu Phe Leu Met Phe Cys Met Ala Gly 
1               5                   10                  15      


Leu Cys Leu Ile Ser Phe Leu His Phe Phe Lys Thr Leu Ser Tyr Val 
            20                  25                  30          


Thr Phe Pro Arg Glu Leu Ala Ser Leu Ser Pro Asn Leu Val Ser Ser 
        35                  40                  45              


Phe Phe Trp Asn Asn Ala Pro Val Thr Pro Gln Ala Ser Pro Glu Pro 
    50                  55                  60                  


Gly Gly Pro Asp Leu Leu Arg Thr Pro Leu Tyr Ser His Ser Pro Leu 
65                  70                  75                  80  


Leu Gln Pro Leu Pro Pro Ser Lys Ala Ala Glu Glu Leu His Arg Val 
                85                  90                  95      


Asp Leu Val Leu Pro Glu Asp Thr Thr Glu Tyr Phe Val Arg Thr Lys 
            100                 105                 110         


Ala Gly Gly Val Cys Phe Lys Pro Gly Thr Lys Met Leu Glu Arg Pro 
        115                 120                 125             


Pro Pro Gly Arg Pro Glu Glu Lys Pro Glu Gly Ala Asn Gly Ser Ser 
    130                 135                 140                 


Ala Arg Arg Pro Pro Arg Tyr Leu Leu Ser Ala Arg Glu Arg Thr Gly 
145                 150                 155                 160 


Gly Arg Gly Ala Arg Arg Lys Trp Val Glu Cys Val Cys Leu Pro Gly 
                165                 170                 175     


Trp His Gly Pro Ser Cys Gly Val Pro Thr Val Val Gln Tyr Ser Asn 
            180                 185                 190         


Leu Pro Thr Lys Glu Arg Leu Val Pro Arg Glu Val Pro Arg Arg Val 
        195                 200                 205             


Ile Asn Ala Ile Asn Val Asn His Glu Phe Asp Leu Leu Asp Val Arg 
    210                 215                 220                 


Phe His Glu Leu Gly Asp Val Val Asp Ala Phe Val Val Cys Glu Ser 
225                 230                 235                 240 


Asn Phe Thr Ala Tyr Gly Glu Pro Arg Pro Leu Lys Phe Arg Glu Met 
                245                 250                 255     


Leu Thr Asn Gly Thr Phe Glu Tyr Ile Arg His Lys Val Leu Tyr Val 
            260                 265                 270         


Phe Leu Asp His Phe Pro Pro Gly Gly Arg Gln Asp Gly Trp Ile Ala 
        275                 280                 285             


Asp Asp Tyr Leu Arg Thr Phe Leu Thr Gln Asp Gly Val Ser Arg Leu 
    290                 295                 300                 


Arg Asn Leu Arg Pro Asp Asp Val Phe Ile Ile Asp Asp Ala Asp Glu 
305                 310                 315                 320 


Ile Pro Ala Arg Asp Gly Val Leu Phe Leu Lys Leu Tyr Asp Gly Trp 
                325                 330                 335     


Thr Glu Pro Phe Ala Phe His Met Arg Lys Ser Leu Tyr Gly Phe Phe 
            340                 345                 350         


Trp Lys Gln Pro Gly Thr Leu Glu Val Val Ser Gly Cys Thr Val Asp 
        355                 360                 365             


Met Leu Gln Ala Val Tyr Gly Leu Asp Gly Ile Arg Leu Arg Arg Arg 
    370                 375                 380                 


Gln Tyr Tyr Thr Met Pro Asn Phe Arg Gln Tyr Glu Asn Arg Thr Gly 
385                 390                 395                 400 


His Ile Leu Val Gln Trp Ser Leu Gly Ser Pro Leu His Phe Ala Gly 
                405                 410                 415     


Trp His Cys Ser Trp Cys Phe Thr Pro Glu Gly Ile Tyr Phe Lys Leu 
            420                 425                 430         


Val Ser Ala Gln Asn Gly Asp Phe Pro Arg Trp Gly Asp Tyr Glu Asp 
        435                 440                 445             


Lys Arg Asp Leu Asn Tyr Ile Arg Gly Leu Ile Arg Thr Gly Gly Trp 
    450                 455                 460                 


Phe Asp Gly Thr Gln Gln Glu Tyr Pro Pro Ala Asp Pro Ser Glu His 
465                 470                 475                 480 


Met Tyr Ala Pro Lys Tyr Leu Leu Lys Asn Tyr Asp Arg Phe His Tyr 
                485                 490                 495     


Leu Leu Asp Asn Pro Tyr Gln Glu Pro Arg Ser Thr Ala Ala Gly Gly 
            500                 505                 510         


Trp Arg His Arg Gly Pro Glu Gly Arg Pro Pro Ala Arg Gly Lys Leu 
        515                 520                 525             


Asp Glu Ala Glu Val 
    530             


<210>  8664
<211>  423
<212>  PRT
<213>  Homo Sapiens

<400>  8664

Met Asn Tyr Ser Ile Thr Val Ser Ile Val Met Gly Ile Pro Thr Val 
1               5                   10                  15      


Lys Arg Glu Val Lys Ser Tyr Leu Ile Glu Thr Leu His Ser Leu Ile 
            20                  25                  30          


Asp Asn Leu Tyr Pro Glu Glu Lys Leu Asp Cys Val Ile Val Val Phe 
        35                  40                  45              


Ile Gly Glu Thr Asp Ile Asp Tyr Val His Gly Val Val Ala Asn Leu 
    50                  55                  60                  


Glu Lys Glu Phe Ser Lys Glu Ile Ser Ser Gly Leu Val Glu Val Ile 
65                  70                  75                  80  


Ser Pro Pro Glu Ser Tyr Tyr Pro Asp Leu Thr Asn Leu Lys Glu Thr 
                85                  90                  95      


Phe Gly Asp Ser Lys Glu Arg Val Arg Trp Arg Thr Lys Gln Asn Leu 
            100                 105                 110         


Asp Tyr Cys Phe Leu Met Met Tyr Ala Gln Glu Lys Gly Ile Tyr Tyr 
        115                 120                 125             


Ile Gln Leu Glu Asp Asp Ile Ile Val Lys Gln Asn Tyr Phe Asn Thr 
    130                 135                 140                 


Ile Lys Asn Phe Ala Leu Gln Leu Ser Ser Glu Glu Trp Met Ile Leu 
145                 150                 155                 160 


Glu Phe Ser Gln Leu Gly Phe Ile Gly Lys Met Phe Gln Ala Pro Asp 
                165                 170                 175     


Leu Thr Leu Ile Val Glu Phe Ile Phe Met Phe Tyr Lys Glu Lys Pro 
            180                 185                 190         


Ile Asp Trp Leu Leu Asp His Ile Leu Trp Val Lys Val Cys Asn Pro 
        195                 200                 205             


Glu Lys Asp Ala Lys His Cys Asp Arg Gln Lys Ala Asn Leu Arg Ile 
    210                 215                 220                 


Arg Phe Arg Pro Ser Leu Phe Gln His Val Gly Leu His Ser Ser Leu 
225                 230                 235                 240 


Ser Gly Lys Ile Gln Lys Leu Thr Asp Lys Asp Tyr Met Lys Pro Leu 
                245                 250                 255     


Leu Leu Lys Ile His Val Asn Pro Pro Ala Glu Val Ser Thr Ser Leu 
            260                 265                 270         


Lys Val Tyr Gln Gly His Thr Leu Glu Lys Thr Tyr Met Gly Glu Asp 
        275                 280                 285             


Phe Phe Trp Ala Ile Thr Pro Ile Ala Gly Asp Tyr Ile Leu Phe Lys 
    290                 295                 300                 


Phe Asp Lys Pro Val Asn Val Glu Ser Tyr Leu Phe His Ser Gly Asn 
305                 310                 315                 320 


Gln Glu His Pro Gly Asp Ile Leu Leu Asn Thr Thr Val Glu Val Leu 
                325                 330                 335     


Pro Phe Lys Ser Glu Gly Leu Glu Ile Ser Lys Glu Thr Lys Asp Lys 
            340                 345                 350         


Arg Leu Glu Asp Gly Tyr Phe Arg Ile Gly Lys Phe Glu Asn Gly Val 
        355                 360                 365             


Ala Glu Gly Met Val Asp Pro Ser Leu Asn Pro Ile Ser Ala Phe Arg 
    370                 375                 380                 


Leu Ser Val Ile Gln Asn Ser Ala Val Trp Ala Ile Leu Asn Glu Gln 
385                 390                 395                 400 


Arg Val Phe Ser Gly Trp Trp Gln Lys Ser Arg Asp Lys Ala Glu Gly 
                405                 410                 415     


Pro Gln Ala Pro Leu Leu Phe 
            420             


<210>  8665
<211>  535
<212>  PRT
<213>  Homo Sapiens

<400>  8665

Met Arg Leu Arg Asn Gly Thr Val Ala Thr Ala Leu Ala Phe Ile Thr 
1               5                   10                  15      


Ser Phe Leu Thr Leu Ser Trp Tyr Thr Thr Trp Gln Asn Gly Lys Glu 
            20                  25                  30          


Lys Leu Ile Ala Tyr Gln Arg Glu Phe Leu Ala Leu Lys Glu Arg Leu 
        35                  40                  45              


Arg Ile Ala Glu His Arg Ile Ser Gln Arg Ser Ser Glu Leu Asn Thr 
    50                  55                  60                  


Ile Val Gln Gln Phe Lys Arg Val Gly Ala Glu Thr Asn Gly Ser Lys 
65                  70                  75                  80  


Asp Ala Leu Asn Lys Phe Ser Asp Asn Thr Leu Lys Leu Leu Lys Glu 
                85                  90                  95      


Leu Thr Ser Lys Lys Ser Leu Gln Val Pro Ser Ile Tyr Tyr His Leu 
            100                 105                 110         


Pro His Leu Leu Lys Asn Glu Gly Ser Leu Gln Pro Ala Val Gln Ile 
        115                 120                 125             


Gly Asn Gly Arg Thr Gly Val Ser Ile Val Met Gly Ile Pro Thr Val 
    130                 135                 140                 


Lys Arg Glu Val Lys Ser Tyr Leu Ile Glu Thr Leu His Ser Leu Ile 
145                 150                 155                 160 


Asp Asn Leu Tyr Pro Glu Glu Lys Leu Asp Cys Val Ile Val Val Phe 
                165                 170                 175     


Ile Gly Glu Thr Asp Ile Asp Tyr Val His Gly Val Val Ala Asn Leu 
            180                 185                 190         


Glu Lys Glu Phe Ser Lys Glu Ile Ser Ser Gly Leu Val Glu Val Ile 
        195                 200                 205             


Ser Pro Pro Glu Ser Tyr Tyr Pro Asp Leu Thr Asn Leu Lys Glu Thr 
    210                 215                 220                 


Phe Gly Asp Ser Lys Glu Arg Val Arg Trp Arg Thr Lys Gln Asn Leu 
225                 230                 235                 240 


Asp Tyr Cys Phe Leu Met Met Tyr Ala Gln Glu Lys Gly Ile Tyr Tyr 
                245                 250                 255     


Ile Gln Leu Glu Asp Asp Ile Ile Val Lys Gln Asn Tyr Phe Asn Thr 
            260                 265                 270         


Ile Lys Asn Phe Ala Leu Gln Leu Ser Ser Glu Glu Trp Met Ile Leu 
        275                 280                 285             


Glu Phe Ser Gln Leu Gly Phe Ile Gly Lys Met Phe Gln Ala Pro Asp 
    290                 295                 300                 


Leu Thr Leu Ile Val Glu Phe Ile Phe Met Phe Tyr Lys Glu Lys Pro 
305                 310                 315                 320 


Ile Asp Trp Leu Leu Asp His Ile Leu Trp Val Lys Val Cys Asn Pro 
                325                 330                 335     


Glu Lys Asp Ala Lys His Cys Asp Arg Gln Lys Ala Asn Leu Arg Ile 
            340                 345                 350         


Arg Phe Arg Pro Ser Leu Phe Gln His Val Gly Leu His Ser Ser Leu 
        355                 360                 365             


Ser Gly Lys Ile Gln Lys Leu Thr Asp Lys Asp Tyr Met Lys Pro Leu 
    370                 375                 380                 


Leu Leu Lys Ile His Val Asn Pro Pro Ala Glu Val Ser Thr Ser Leu 
385                 390                 395                 400 


Lys Val Tyr Gln Gly His Thr Leu Glu Lys Thr Tyr Met Gly Glu Asp 
                405                 410                 415     


Phe Phe Trp Ala Ile Thr Pro Ile Ala Gly Asp Tyr Ile Leu Phe Lys 
            420                 425                 430         


Phe Asp Lys Pro Val Asn Val Glu Ser Tyr Leu Phe His Ser Gly Asn 
        435                 440                 445             


Gln Glu His Pro Gly Asp Ile Leu Leu Asn Thr Thr Val Glu Val Leu 
    450                 455                 460                 


Pro Phe Lys Ser Glu Gly Leu Glu Ile Ser Lys Glu Thr Lys Asp Lys 
465                 470                 475                 480 


Arg Leu Glu Asp Gly Tyr Phe Arg Ile Gly Lys Phe Glu Asn Gly Val 
                485                 490                 495     


Ala Glu Gly Met Val Asp Pro Ser Leu Asn Pro Ile Ser Ala Phe Arg 
            500                 505                 510         


Leu Ser Val Ile Gln Asn Ser Ala Val Trp Ala Ile Leu Asn Glu Ile 
        515                 520                 525             


His Ile Lys Lys Ala Thr Asn 
    530                 535 


<210>  8666
<211>  535
<212>  PRT
<213>  Homo Sapiens

<400>  8666

Met Arg Leu Arg Asn Gly Thr Val Ala Thr Ala Leu Ala Phe Ile Thr 
1               5                   10                  15      


Ser Phe Leu Thr Leu Ser Trp Tyr Thr Thr Trp Gln Asn Gly Lys Glu 
            20                  25                  30          


Lys Leu Ile Ala Tyr Gln Arg Glu Phe Leu Ala Leu Lys Glu Arg Leu 
        35                  40                  45              


Arg Ile Ala Glu His Arg Ile Ser Gln Arg Ser Ser Glu Leu Asn Thr 
    50                  55                  60                  


Ile Val Gln Gln Phe Lys Arg Val Gly Ala Glu Thr Asn Gly Ser Lys 
65                  70                  75                  80  


Asp Ala Leu Asn Lys Phe Ser Asp Asn Thr Leu Lys Leu Leu Lys Glu 
                85                  90                  95      


Leu Thr Ser Lys Lys Ser Leu Gln Val Pro Ser Ile Tyr Tyr His Leu 
            100                 105                 110         


Pro His Leu Leu Lys Asn Glu Gly Ser Leu Gln Pro Ala Val Gln Ile 
        115                 120                 125             


Gly Asn Gly Arg Thr Gly Val Ser Ile Val Met Gly Ile Pro Thr Val 
    130                 135                 140                 


Lys Arg Glu Val Lys Ser Tyr Leu Ile Glu Thr Leu His Ser Leu Ile 
145                 150                 155                 160 


Asp Asn Leu Tyr Pro Glu Glu Lys Leu Asp Cys Val Ile Val Val Phe 
                165                 170                 175     


Ile Gly Glu Thr Asp Ile Asp Tyr Val His Gly Val Val Ala Asn Leu 
            180                 185                 190         


Glu Lys Glu Phe Ser Lys Glu Ile Ser Ser Gly Leu Val Glu Val Ile 
        195                 200                 205             


Ser Pro Pro Glu Ser Tyr Tyr Pro Asp Leu Thr Asn Leu Lys Glu Thr 
    210                 215                 220                 


Phe Gly Asp Ser Lys Glu Arg Val Arg Trp Arg Thr Lys Gln Asn Leu 
225                 230                 235                 240 


Asp Tyr Cys Phe Leu Met Met Tyr Ala Gln Glu Lys Gly Ile Tyr Tyr 
                245                 250                 255     


Ile Gln Leu Glu Asp Asp Ile Ile Val Lys Gln Asn Tyr Phe Asn Thr 
            260                 265                 270         


Ile Lys Asn Phe Ala Leu Gln Leu Ser Ser Glu Glu Trp Met Ile Leu 
        275                 280                 285             


Glu Phe Ser Gln Leu Gly Phe Ile Gly Lys Met Phe Gln Ala Pro Asp 
    290                 295                 300                 


Leu Thr Leu Ile Val Glu Phe Ile Phe Met Phe Tyr Lys Glu Lys Pro 
305                 310                 315                 320 


Ile Asp Trp Leu Leu Asp His Ile Leu Trp Val Lys Val Cys Asn Pro 
                325                 330                 335     


Glu Lys Asp Ala Lys His Cys Asp Arg Gln Lys Ala Asn Leu Arg Ile 
            340                 345                 350         


Arg Phe Arg Pro Ser Leu Phe Gln His Val Gly Leu His Ser Ser Leu 
        355                 360                 365             


Ser Gly Lys Ile Gln Lys Leu Thr Asp Lys Asp Tyr Met Lys Pro Leu 
    370                 375                 380                 


Leu Leu Lys Ile His Val Asn Pro Pro Ala Glu Val Ser Thr Ser Leu 
385                 390                 395                 400 


Lys Val Tyr Gln Gly His Thr Leu Glu Lys Thr Tyr Met Gly Glu Asp 
                405                 410                 415     


Phe Phe Trp Ala Ile Thr Pro Ile Ala Gly Asp Tyr Ile Leu Phe Lys 
            420                 425                 430         


Phe Asp Lys Pro Val Asn Val Glu Ser Tyr Leu Phe His Ser Gly Asn 
        435                 440                 445             


Gln Glu His Pro Gly Asp Ile Leu Leu Asn Thr Thr Val Glu Val Leu 
    450                 455                 460                 


Pro Phe Lys Ser Glu Gly Leu Glu Ile Ser Lys Glu Thr Lys Asp Lys 
465                 470                 475                 480 


Arg Leu Glu Asp Gly Tyr Phe Arg Ile Gly Lys Phe Glu Asn Gly Val 
                485                 490                 495     


Ala Glu Gly Met Val Asp Pro Ser Leu Asn Pro Ile Ser Ala Phe Arg 
            500                 505                 510         


Leu Ser Val Ile Gln Asn Ser Ala Val Trp Ala Ile Leu Asn Glu Ile 
        515                 520                 525             


His Ile Lys Lys Ala Thr Asn 
    530                 535 


<210>  8667
<211>  535
<212>  PRT
<213>  Homo Sapiens

<400>  8667

Met Arg Leu Arg Asn Gly Thr Val Ala Thr Ala Leu Ala Phe Ile Thr 
1               5                   10                  15      


Ser Phe Leu Thr Leu Ser Trp Tyr Thr Thr Trp Gln Asn Gly Lys Glu 
            20                  25                  30          


Lys Leu Ile Ala Tyr Gln Arg Glu Phe Leu Ala Leu Lys Glu Arg Leu 
        35                  40                  45              


Arg Ile Ala Glu His Arg Ile Ser Gln Arg Ser Ser Glu Leu Asn Thr 
    50                  55                  60                  


Ile Val Gln Gln Phe Lys Arg Val Gly Ala Glu Thr Asn Gly Ser Lys 
65                  70                  75                  80  


Asp Ala Leu Asn Lys Phe Ser Asp Asn Thr Leu Lys Leu Leu Lys Glu 
                85                  90                  95      


Leu Thr Ser Lys Lys Ser Leu Gln Val Pro Ser Ile Tyr Tyr His Leu 
            100                 105                 110         


Pro His Leu Leu Lys Asn Glu Gly Ser Leu Gln Pro Ala Val Gln Ile 
        115                 120                 125             


Gly Asn Gly Arg Thr Gly Val Ser Ile Val Met Gly Ile Pro Thr Val 
    130                 135                 140                 


Lys Arg Glu Val Lys Ser Tyr Leu Ile Glu Thr Leu His Ser Leu Ile 
145                 150                 155                 160 


Asp Asn Leu Tyr Pro Glu Glu Lys Leu Asp Cys Val Ile Val Val Phe 
                165                 170                 175     


Ile Gly Glu Thr Asp Ile Asp Tyr Val His Gly Val Val Ala Asn Leu 
            180                 185                 190         


Glu Lys Glu Phe Ser Lys Glu Ile Ser Ser Gly Leu Val Glu Val Ile 
        195                 200                 205             


Ser Pro Pro Glu Ser Tyr Tyr Pro Asp Leu Thr Asn Leu Lys Glu Thr 
    210                 215                 220                 


Phe Gly Asp Ser Lys Glu Arg Val Arg Trp Arg Thr Lys Gln Asn Leu 
225                 230                 235                 240 


Asp Tyr Cys Phe Leu Met Met Tyr Ala Gln Glu Lys Gly Ile Tyr Tyr 
                245                 250                 255     


Ile Gln Leu Glu Asp Asp Ile Ile Val Lys Gln Asn Tyr Phe Asn Thr 
            260                 265                 270         


Ile Lys Asn Phe Ala Leu Gln Leu Ser Ser Glu Glu Trp Met Ile Leu 
        275                 280                 285             


Glu Phe Ser Gln Leu Gly Phe Ile Gly Lys Met Phe Gln Ala Pro Asp 
    290                 295                 300                 


Leu Thr Leu Ile Val Glu Phe Ile Phe Met Phe Tyr Lys Glu Lys Pro 
305                 310                 315                 320 


Ile Asp Trp Leu Leu Asp His Ile Leu Trp Val Lys Val Cys Asn Pro 
                325                 330                 335     


Glu Lys Asp Ala Lys His Cys Asp Arg Gln Lys Ala Asn Leu Arg Ile 
            340                 345                 350         


Arg Phe Arg Pro Ser Leu Phe Gln His Val Gly Leu His Ser Ser Leu 
        355                 360                 365             


Ser Gly Lys Ile Gln Lys Leu Thr Asp Lys Asp Tyr Met Lys Pro Leu 
    370                 375                 380                 


Leu Leu Lys Ile His Val Asn Pro Pro Ala Glu Val Ser Thr Ser Leu 
385                 390                 395                 400 


Lys Val Tyr Gln Gly His Thr Leu Glu Lys Thr Tyr Met Gly Glu Asp 
                405                 410                 415     


Phe Phe Trp Ala Ile Thr Pro Ile Ala Gly Asp Tyr Ile Leu Phe Lys 
            420                 425                 430         


Phe Asp Lys Pro Val Asn Val Glu Ser Tyr Leu Phe His Ser Gly Asn 
        435                 440                 445             


Gln Glu His Pro Gly Asp Ile Leu Leu Asn Thr Thr Val Glu Val Leu 
    450                 455                 460                 


Pro Phe Lys Ser Glu Gly Leu Glu Ile Ser Lys Glu Thr Lys Asp Lys 
465                 470                 475                 480 


Arg Leu Glu Asp Gly Tyr Phe Arg Ile Gly Lys Phe Glu Asn Gly Val 
                485                 490                 495     


Ala Glu Gly Met Val Asp Pro Ser Leu Asn Pro Ile Ser Ala Phe Arg 
            500                 505                 510         


Leu Ser Val Ile Gln Asn Ser Ala Val Trp Ala Ile Leu Asn Glu Ile 
        515                 520                 525             


His Ile Lys Lys Ala Thr Asn 
    530                 535 


<210>  8668
<211>  44
<212>  PRT
<213>  Homo Sapiens

<400>  8668

Met Arg Leu Arg Asn Gly Thr Val Ala Thr Ala Leu Ala Phe Ile Thr 
1               5                   10                  15      


Ser Phe Leu Thr Leu Ser Trp Tyr Thr Thr Trp Gln Asn Gly Lys Gly 
            20                  25                  30          


Lys Glu Asn Asp Ser Glu Asn Val His Glu Met Tyr 
        35                  40                  


<210>  8669
<211>  200
<212>  PRT
<213>  Homo Sapiens

<400>  8669

Met Gly Ile Pro Ser Val Arg Arg Glu Val His Ser Tyr Leu Thr Asp 
1               5                   10                  15      


Thr Leu His Ser Leu Ile Ser Glu Leu Ser Pro Gln Glu Lys Glu Asp 
            20                  25                  30          


Ser Val Ile Val Val Leu Ile Ala Glu Thr Asp Ser Gln Tyr Thr Ser 
        35                  40                  45              


Ala Val Thr Glu Asn Ile Lys Ala Leu Phe Pro Thr Glu Ile His Ser 
    50                  55                  60                  


Gly Leu Leu Glu Val Ile Ser Pro Ser Pro His Phe Tyr Pro Asp Phe 
65                  70                  75                  80  


Ser Arg Leu Arg Glu Ser Phe Gly Asp Pro Lys Glu Arg Val Arg Trp 
                85                  90                  95      


Arg Thr Lys Gln Asn Leu Asp Tyr Cys Phe Leu Met Met Tyr Ala Gln 
            100                 105                 110         


Ser Lys Gly Ile Tyr Tyr Val Gln Leu Glu Asp Asp Ile Val Ala Lys 
        115                 120                 125             


Pro Asn Tyr Leu Ser Thr Met Lys Asn Phe Ala Leu Gln Gln Pro Ser 
    130                 135                 140                 


Glu Asp Trp Met Ile Leu Glu Phe Ser Gln Leu Gly Phe Ile Gly Lys 
145                 150                 155                 160 


Met Phe Lys Ser Leu Asp Leu Ser Leu Ile Val Glu Phe Ile Leu Met 
                165                 170                 175     


Phe Tyr Arg Asp Lys Pro Ile Asp Trp Leu Leu Asp His Ile Leu Trp 
            180                 185                 190         


Val Lys Val Cys Asn Pro Glu Lys 
        195                 200 


<210>  8670
<211>  548
<212>  PRT
<213>  Homo Sapiens

<400>  8670

Met Arg Leu Arg Asn Gly Thr Phe Leu Thr Leu Leu Leu Phe Cys Leu 
1               5                   10                  15      


Cys Ala Phe Leu Ser Leu Ser Trp Tyr Ala Ala Leu Ser Gly Gln Lys 
            20                  25                  30          


Gly Asp Val Val Asp Val Tyr Gln Arg Glu Phe Leu Ala Leu Arg Asp 
        35                  40                  45              


Arg Leu His Ala Ala Glu Gln Glu Ser Leu Lys Arg Ser Lys Glu Leu 
    50                  55                  60                  


Asn Leu Val Leu Asp Glu Ile Lys Arg Ala Val Ser Glu Arg Gln Ala 
65                  70                  75                  80  


Leu Arg Asp Gly Asp Gly Asn Arg Thr Trp Gly Arg Leu Thr Glu Asp 
                85                  90                  95      


Pro Arg Leu Lys Pro Trp Asn Gly Ser His Arg His Val Leu His Leu 
            100                 105                 110         


Pro Thr Val Phe His His Leu Pro His Leu Leu Ala Lys Glu Ser Ser 
        115                 120                 125             


Leu Gln Pro Ala Val Arg Val Gly Gln Gly Arg Thr Gly Val Ser Val 
    130                 135                 140                 


Val Met Gly Ile Pro Ser Val Arg Arg Glu Val His Ser Tyr Leu Thr 
145                 150                 155                 160 


Asp Thr Leu His Ser Leu Ile Ser Glu Leu Ser Pro Gln Glu Lys Glu 
                165                 170                 175     


Asp Ser Val Ile Val Val Leu Ile Ala Glu Thr Asp Ser Gln Tyr Thr 
            180                 185                 190         


Ser Ala Val Thr Glu Asn Ile Lys Ala Leu Phe Pro Thr Glu Ile His 
        195                 200                 205             


Ser Gly Leu Leu Glu Val Ile Ser Pro Ser Pro His Phe Tyr Pro Asp 
    210                 215                 220                 


Phe Ser Arg Leu Arg Glu Ser Phe Gly Asp Pro Lys Glu Arg Val Arg 
225                 230                 235                 240 


Trp Arg Thr Lys Gln Asn Leu Asp Tyr Cys Phe Leu Met Met Tyr Ala 
                245                 250                 255     


Gln Ser Lys Gly Ile Tyr Tyr Val Gln Leu Glu Asp Asp Ile Val Ala 
            260                 265                 270         


Lys Pro Asn Tyr Leu Ser Thr Met Lys Asn Phe Ala Leu Gln Gln Pro 
        275                 280                 285             


Ser Glu Asp Trp Met Ile Leu Glu Phe Ser Gln Leu Gly Phe Ile Gly 
    290                 295                 300                 


Lys Met Phe Lys Ser Leu Asp Leu Ser Leu Ile Val Glu Phe Ile Leu 
305                 310                 315                 320 


Met Phe Tyr Arg Asp Lys Pro Ile Asp Trp Leu Leu Asp His Ile Leu 
                325                 330                 335     


Trp Val Lys Val Cys Asn Pro Glu Lys Asp Ala Lys His Cys Asp Arg 
            340                 345                 350         


Gln Lys Ala Asn Leu Arg Ile Arg Phe Lys Pro Ser Leu Phe Gln His 
        355                 360                 365             


Val Gly Thr His Ser Ser Leu Ala Gly Lys Ile Gln Lys Leu Lys Asp 
    370                 375                 380                 


Lys Asp Phe Gly Lys Gln Ala Leu Arg Lys Glu His Val Asn Pro Pro 
385                 390                 395                 400 


Ala Glu Val Ser Thr Ser Leu Lys Thr Tyr Gln His Phe Thr Leu Glu 
                405                 410                 415     


Lys Ala Tyr Leu Arg Glu Asp Phe Phe Trp Ala Phe Thr Pro Ala Ala 
            420                 425                 430         


Gly Asp Phe Ile Arg Phe Arg Phe Phe Gln Pro Leu Arg Leu Glu Arg 
        435                 440                 445             


Phe Phe Phe Arg Ser Gly Asn Ile Glu His Pro Glu Asp Lys Leu Phe 
    450                 455                 460                 


Asn Thr Ser Val Glu Val Leu Pro Phe Asp Asn Pro Gln Ser Asp Lys 
465                 470                 475                 480 


Glu Ala Leu Gln Glu Gly Arg Thr Ala Thr Leu Arg Tyr Pro Arg Ser 
                485                 490                 495     


Pro Asp Gly Tyr Leu Gln Ile Gly Ser Phe Tyr Lys Gly Val Ala Glu 
            500                 505                 510         


Gly Glu Val Asp Pro Ala Phe Gly Pro Leu Glu Ala Leu Arg Leu Ser 
        515                 520                 525             


Ile Gln Thr Asp Ser Pro Val Trp Val Ile Leu Ser Glu Ile Phe Leu 
    530                 535                 540                 


Lys Lys Ala Asp 
545             


<210>  8671
<211>  157
<212>  PRT
<213>  Homo Sapiens

<400>  8671

Met Ser Arg Val Ala Gly Thr Arg Thr Asp Val Asn Glu Leu Leu Gln 
1               5                   10                  15      


Arg Trp Thr Pro Arg Cys Val Arg Trp His Thr Gly Gly Ala Arg Arg 
            20                  25                  30          


Val Ala Leu Asp Arg Pro Leu Val Thr Ala Cys Leu Pro Pro Ala Gly 
        35                  40                  45              


Asp Val Val Asp Val Tyr Gln Arg Glu Phe Leu Ala Leu Arg Asp Arg 
    50                  55                  60                  


Leu His Ala Ala Glu Gln Glu Ser Leu Lys Arg Ser Lys Glu Leu Asn 
65                  70                  75                  80  


Leu Val Leu Asp Glu Ile Lys Arg Ala Val Ser Glu Arg Gln Ala Leu 
                85                  90                  95      


Arg Asp Gly Asp Gly Asn Arg Thr Trp Gly Arg Leu Thr Glu Asp Pro 
            100                 105                 110         


Arg Leu Lys Pro Trp Asn Gly Ser His Arg His Val Leu His Leu Pro 
        115                 120                 125             


Thr Val Phe His His Leu Pro His Leu Leu Ala Lys Glu Ser Ser Leu 
    130                 135                 140                 


Gln Pro Ala Val Arg Val Gly Gln Gly Arg Thr Gly Asp 
145                 150                 155         


<210>  8672
<211>  563
<212>  PRT
<213>  Homo Sapiens

<400>  8672

Met Ser Arg Val Ala Gly Thr Arg Thr Asp Val Asn Glu Leu Leu Gln 
1               5                   10                  15      


Arg Trp Thr Pro Arg Cys Val Arg Trp His Thr Gly Gly Ala Arg Arg 
            20                  25                  30          


Val Ala Leu Asp Arg Pro Leu Val Thr Ala Cys Leu Pro Pro Ala Gly 
        35                  40                  45              


Asp Val Val Asp Val Tyr Gln Arg Glu Phe Leu Ala Leu Arg Asp Arg 
    50                  55                  60                  


Leu His Ala Ala Glu Gln Glu Ser Leu Lys Arg Ser Lys Glu Leu Asn 
65                  70                  75                  80  


Leu Val Leu Asp Glu Ile Lys Arg Ala Val Ser Glu Arg Gln Ala Leu 
                85                  90                  95      


Arg Asp Gly Asp Gly Asn Arg Thr Trp Gly Arg Leu Thr Glu Asp Pro 
            100                 105                 110         


Arg Leu Lys Pro Trp Asn Gly Ser His Arg His Val Leu His Leu Pro 
        115                 120                 125             


Thr Val Phe His His Leu Pro His Leu Leu Ala Lys Glu Ser Ser Leu 
    130                 135                 140                 


Gln Pro Ala Val Arg Val Gly Gln Gly Arg Thr Gly Val Ser Val Val 
145                 150                 155                 160 


Met Gly Ile Pro Ser Val Arg Arg Glu Val His Ser Tyr Leu Thr Asp 
                165                 170                 175     


Thr Leu His Ser Leu Ile Ser Glu Leu Ser Pro Gln Glu Lys Glu Asp 
            180                 185                 190         


Ser Val Ile Val Val Leu Ile Ala Glu Thr Asp Ser Gln Tyr Thr Ser 
        195                 200                 205             


Ala Val Thr Glu Asn Ile Lys Ala Leu Phe Pro Thr Glu Ile His Ser 
    210                 215                 220                 


Gly Leu Leu Glu Val Ile Ser Pro Ser Pro His Phe Tyr Pro Asp Phe 
225                 230                 235                 240 


Ser Arg Leu Arg Glu Ser Phe Gly Asp Pro Lys Glu Arg Val Arg Trp 
                245                 250                 255     


Arg Thr Lys Gln Asn Leu Asp Tyr Cys Phe Leu Met Met Tyr Ala Gln 
            260                 265                 270         


Ser Lys Gly Ile Tyr Tyr Val Gln Leu Glu Asp Asp Ile Val Ala Lys 
        275                 280                 285             


Pro Asn Tyr Leu Ser Thr Met Lys Asn Phe Ala Leu Gln Gln Pro Ser 
    290                 295                 300                 


Glu Asp Trp Met Ile Leu Glu Phe Ser Gln Leu Gly Phe Ile Gly Lys 
305                 310                 315                 320 


Met Phe Lys Ser Leu Asp Leu Ser Leu Ile Val Glu Phe Ile Leu Met 
                325                 330                 335     


Phe Tyr Arg Asp Lys Pro Ile Asp Trp Leu Leu Asp His Ile Leu Trp 
            340                 345                 350         


Val Lys Val Cys Asn Pro Glu Lys Asp Ala Lys His Cys Asp Arg Gln 
        355                 360                 365             


Lys Ala Asn Leu Arg Ile Arg Phe Lys Pro Ser Leu Phe Gln His Val 
    370                 375                 380                 


Gly Thr His Ser Ser Leu Ala Gly Lys Ile Gln Lys Leu Lys Asp Lys 
385                 390                 395                 400 


Asp Phe Gly Lys Gln Ala Leu Arg Lys Glu His Val Asn Pro Pro Ala 
                405                 410                 415     


Glu Val Ser Thr Ser Leu Lys Thr Tyr Gln His Phe Thr Leu Glu Lys 
            420                 425                 430         


Ala Tyr Leu Arg Glu Asp Phe Phe Trp Ala Phe Thr Pro Ala Ala Gly 
        435                 440                 445             


Asp Phe Ile Arg Phe Arg Phe Phe Gln Pro Leu Arg Leu Glu Arg Phe 
    450                 455                 460                 


Phe Phe Arg Ser Gly Asn Ile Glu His Pro Glu Asp Lys Leu Phe Asn 
465                 470                 475                 480 


Thr Ser Val Glu Val Leu Pro Phe Asp Asn Pro Gln Ser Asp Lys Glu 
                485                 490                 495     


Ala Leu Gln Glu Gly Arg Thr Ala Thr Leu Arg Tyr Pro Arg Ser Pro 
            500                 505                 510         


Asp Gly Tyr Leu Gln Ile Gly Ser Phe Tyr Lys Gly Val Ala Glu Gly 
        515                 520                 525             


Glu Val Asp Pro Ala Phe Gly Pro Leu Glu Ala Leu Arg Leu Ser Ile 
    530                 535                 540                 


Gln Thr Asp Ser Pro Val Trp Val Ile Leu Ser Glu Ile Phe Leu Lys 
545                 550                 555                 560 


Lys Ala Asp 
            


<210>  8673
<211>  373
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8673

Xaa Glu Asp Ser Val Ile Val Val Leu Ile Ala Glu Thr Asp Ser Gln 
1               5                   10                  15      


Tyr Thr Ser Ala Val Thr Glu Asn Ile Lys Ala Leu Phe Pro Thr Glu 
            20                  25                  30          


Ile His Ser Gly Leu Leu Glu Val Ile Ser Pro Ser Pro His Phe Tyr 
        35                  40                  45              


Pro Asp Phe Ser Arg Leu Arg Glu Ser Phe Gly Asp Pro Lys Glu Arg 
    50                  55                  60                  


Val Arg Trp Arg Thr Lys Gln Asn Leu Asp Tyr Cys Phe Leu Met Met 
65                  70                  75                  80  


Tyr Ala Gln Ser Lys Gly Ile Tyr Tyr Val Gln Leu Glu Asp Asp Ile 
                85                  90                  95      


Val Ala Lys Pro Asn Tyr Leu Ser Thr Met Lys Asn Phe Ala Leu Gln 
            100                 105                 110         


Gln Pro Ser Glu Asp Trp Met Ile Leu Glu Phe Ser Gln Leu Gly Phe 
        115                 120                 125             


Ile Gly Lys Met Phe Lys Ser Leu Asp Leu Ser Leu Ile Val Glu Phe 
    130                 135                 140                 


Ile Leu Met Phe Tyr Arg Asp Lys Pro Ile Asp Trp Leu Leu Asp His 
145                 150                 155                 160 


Ile Leu Trp Val Lys Val Cys Asn Pro Glu Lys Asp Ala His Cys Asp 
                165                 170                 175     


Arg Gln Lys Ala Asn Leu Arg Ile Arg Phe Lys Pro Ser Leu Phe Gln 
            180                 185                 190         


His Val Gly Thr His Ser Ser Leu Ala Gly Lys Ile Gln Lys Leu Lys 
        195                 200                 205             


Asp Lys Asp Phe Gly Lys Gln Ala Leu Arg Lys Glu His Val Asn Pro 
    210                 215                 220                 


Pro Ala Glu Val Ser Thr Ser Leu Lys Thr Tyr Gln His Phe Thr Leu 
225                 230                 235                 240 


Glu Lys Ala Tyr Leu Arg Glu Asp Phe Phe Trp Ala Phe Thr Pro Ala 
                245                 250                 255     


Ala Gly Asp Phe Ile Arg Phe Arg Phe Phe Gln Pro Leu Arg Leu Glu 
            260                 265                 270         


Arg Phe Phe Phe Arg Ser Gly Asn Ile Glu His Pro Glu Asp Lys Leu 
        275                 280                 285             


Phe Asn Thr Ser Val Glu Val Leu Pro Phe Asp Asn Pro Gln Ser Asp 
    290                 295                 300                 


Lys Glu Ala Leu Gln Glu Gly Arg Thr Ala Thr Leu Arg Tyr Pro Arg 
305                 310                 315                 320 


Ser Pro Asp Gly Tyr Leu Gln Ile Gly Ser Phe Tyr Lys Gly Val Ala 
                325                 330                 335     


Glu Gly Glu Val Asp Pro Ala Phe Gly Pro Leu Glu Ala Leu Arg Leu 
            340                 345                 350         


Ser Ile Gln Thr Asp Ser Pro Val Trp Val Ile Leu Ser Glu Ile Phe 
        355                 360                 365             


Leu Lys Lys Ala Asp 
    370             


<210>  8674
<211>  429
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8674

Xaa Glu Gln Glu Ser Leu Lys Arg Ser Lys Glu Leu Asn Leu Val Leu 
1               5                   10                  15      


Asp Glu Ile Lys Arg Ala Val Ser Glu Arg Gln Ala Leu Arg Asp Gly 
            20                  25                  30          


Asp Gly Asn Arg Thr Trp Gly Arg Leu Thr Glu Asp Pro Arg Leu Lys 
        35                  40                  45              


Pro Trp Asn Gly Ser His Arg His Val Leu His Leu Pro Thr Val Phe 
    50                  55                  60                  


His His Leu Pro His Leu Leu Ala Lys Glu Ser Ser Leu Gln Pro Ala 
65                  70                  75                  80  


Val Arg Val Gly Gln Gly Arg Thr Gly Val Ser Val Val Met Gly Ile 
                85                  90                  95      


Pro Ser Val Arg Arg Glu Val His Ser Tyr Leu Thr Asp Thr Leu His 
            100                 105                 110         


Ser Leu Ile Ser Glu Leu Ser Pro Gln Glu Lys Glu Asp Ser Val Ile 
        115                 120                 125             


Val Val Leu Ile Ala Glu Thr Asp Ser Gln Tyr Thr Ser Ala Val Thr 
    130                 135                 140                 


Glu Asn Ile Lys Ala Leu Phe Pro Thr Glu Ile His Ser Gly Leu Leu 
145                 150                 155                 160 


Glu Val Ile Ser Pro Ser Pro His Phe Tyr Pro Asp Phe Ser Arg Leu 
                165                 170                 175     


Arg Glu Ser Phe Gly Asp Pro Lys Glu Arg Val Arg Trp Arg Thr Lys 
            180                 185                 190         


Gln Asn Leu Asp Tyr Cys Phe Leu Met Met Tyr Ala Gln Ser Lys Gly 
        195                 200                 205             


Ile Tyr Tyr Val Gln Leu Glu Asp Asp Ile Val Ala Lys Pro Asn Tyr 
    210                 215                 220                 


Leu Ser Thr Met Lys Asn Phe Ala Leu Gln Gln Pro Ser Glu Asp Trp 
225                 230                 235                 240 


Met Ile Leu Glu Phe Ser Gln Leu Gly Phe Ile Gly Gln Arg Leu Trp 
                245                 250                 255     


Lys Ala Gly Ala Ala Glu Gly Ala Cys Glu Pro Ala Ser Arg Gly Glu 
            260                 265                 270         


His Glu Pro Glu Asp Ile Pro Ala Leu His Pro Gly Glu Ser Leu Pro 
        275                 280                 285             


Ala Arg Gly Leu Leu Leu Gly Leu His Pro Cys Arg Gly Gly Leu His 
    290                 295                 300                 


Pro Leu Pro Leu Leu Pro Thr Ser Lys Thr Gly Ala Val Leu Leu Pro 
305                 310                 315                 320 


Gln Trp Glu His Arg Ala Pro Gly Gly Gln Ala Leu Gln His Val Cys 
                325                 330                 335     


Gly Gly Ala Ala Leu Arg Gln Pro Ser Val Arg Gln Gly Gly Pro Ala 
            340                 345                 350         


Gly Gly Pro His Arg His Pro Pro Val Pro Ser Glu Pro Arg Arg Leu 
        355                 360                 365             


Pro Pro Asp Arg Leu Leu Leu Gln Gly Ser Gly Arg Gly Arg Gly Gly 
    370                 375                 380                 


Pro Ser Leu Arg Pro Ser Gly Ser Thr Ala Pro Leu Asp Pro Asp Gly 
385                 390                 395                 400 


Leu Pro Cys Val Gly Asp Ser Glu Arg Asp Leu Pro Glu Lys Gly Arg 
                405                 410                 415     


Leu Ser Cys Gly Leu Leu Arg Val Pro Cys Gly Gln Pro 
            420                 425                 


<210>  8675
<211>  322
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8675

Xaa Phe Pro Thr Glu Ile His Ser Gly Leu Leu Glu Val Ile Ser Pro 
1               5                   10                  15      


Ser Pro His Phe Tyr Pro Asp Phe Ser Arg Leu Arg Glu Ser Phe Gly 
            20                  25                  30          


Asp Pro Lys Glu Arg Val Arg Trp Arg Thr Lys Gln Asn Leu Asp Tyr 
        35                  40                  45              


Cys Phe Leu Met Met Tyr Ala Gln Ser Lys Gly Ile Tyr Tyr Val Gln 
    50                  55                  60                  


Leu Glu Asp Asp Ile Val Ala Lys Pro Asn Tyr Leu Ser Thr Met Lys 
65                  70                  75                  80  


Asn Phe Ala Leu Gln Gln Pro Ser Glu Asp Trp Met Ile Leu Glu Phe 
                85                  90                  95      


Ser Gln Leu Gly Phe Ile Gly Lys Met Phe Lys Ser Leu Asp Leu Ser 
            100                 105                 110         


Leu Ile Val Glu Phe Ile Leu Met Phe Tyr Arg Asp Lys Pro Ile Asp 
        115                 120                 125             


Trp Leu Leu Asp His Ile Leu Trp Val Lys Val Cys Asn Pro Glu Lys 
    130                 135                 140                 


Asp Ala Ala Gly Ile Lys Val Gly Ala His Ala Ile Thr Ala Val Pro 
145                 150                 155                 160 


Pro Pro Leu Gln Asp Lys Asp Phe Gly Lys Gln Ala Leu Arg Lys Glu 
                165                 170                 175     


His Val Asn Pro Pro Ala Glu Val Ser Thr Ser Leu Lys Thr Tyr Gln 
            180                 185                 190         


His Phe Thr Leu Glu Lys Ala Tyr Leu Arg Glu Asp Phe Phe Trp Ala 
        195                 200                 205             


Phe Thr Pro Ala Ala Gly Asp Phe Ile Arg Phe Arg Phe Phe Gln Pro 
    210                 215                 220                 


Leu Arg Leu Glu Arg Phe Phe Phe Arg Ser Gly Asn Ile Glu His Pro 
225                 230                 235                 240 


Glu Asp Lys Leu Phe Asn Thr Ser Val Glu Val Leu Pro Phe Asp Asn 
                245                 250                 255     


Pro Gln Ser Asp Lys Glu Ala Leu Gln Glu Gly Arg Thr Ala Thr Leu 
            260                 265                 270         


Arg Tyr Pro Arg Ser Pro Asp Gly Tyr Leu Gln Ile Gly Ser Phe Tyr 
        275                 280                 285             


Lys Gly Val Ala Glu Gly Glu Val Asp Pro Ala Phe Gly Pro Leu Glu 
    290                 295                 300                 


Ala Leu Arg Leu Ser Ile Gln Thr Asp Ser Pro Val Trp Val Ile Leu 
305                 310                 315                 320 


Ser Glu 
        


<210>  8676
<211>  240
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8676

Xaa Lys Met Phe Lys Ser Leu Asp Leu Ser Leu Ile Val Glu Phe Ile 
1               5                   10                  15      


Leu Met Phe Tyr Arg Asp Lys Pro Ile Asp Trp Leu Leu Asp His Ile 
            20                  25                  30          


Leu Trp Val Lys Val Cys Asn Pro Glu Lys Asp Ala Lys His Cys Asp 
        35                  40                  45              


Arg Gln Lys Ala Asn Leu Arg Ile Arg Phe Lys Pro Ser Leu Phe Gln 
    50                  55                  60                  


His Val Gly Thr His Ser Ser Leu Ala Gly Lys Ile Gln Lys Leu Lys 
65                  70                  75                  80  


Asp Lys Asp Phe Gly Lys Gln Ala Leu Arg Lys Glu His Val Asn Pro 
                85                  90                  95      


Pro Ala Glu Val Ser Thr Ser Leu Lys Thr Tyr Gln His Phe Thr Leu 
            100                 105                 110         


Glu Lys Ala Tyr Leu Arg Glu Asp Phe Phe Trp Ala Phe Thr Pro Ala 
        115                 120                 125             


Ala Gly Asp Phe Ile Arg Phe Arg Phe Phe Gln Pro Leu Arg Leu Glu 
    130                 135                 140                 


Arg Gly Asn Ile Glu His Pro Glu Asp Lys Leu Phe Asn Thr Ser Val 
145                 150                 155                 160 


Glu Val Leu Pro Phe Asp Asn Pro Gln Ser Asp Lys Glu Ala Leu Gln 
                165                 170                 175     


Glu Gly Arg Thr Ala Thr Leu Arg Tyr Pro Arg Ser Pro Asp Gly Tyr 
            180                 185                 190         


Leu Gln Ile Gly Ser Phe Tyr Lys Gly Val Ala Glu Gly Glu Val Asp 
        195                 200                 205             


Pro Ala Phe Gly Pro Leu Glu Ala Leu Arg Leu Ser Ile Gln Thr Asp 
    210                 215                 220                 


Ser Pro Val Trp Val Ile Leu Ser Glu Ile Phe Leu Lys Lys Ala Asp 
225                 230                 235                 240 


<210>  8677
<211>  150
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8677

Xaa Leu Leu Leu Phe Cys Leu Cys Ala Phe Leu Ser Leu Ser Trp Tyr 
1               5                   10                  15      


Ala Ala Leu Ser Gly Gln Lys Gly Asp Val Val Asp Val Tyr Gln Arg 
            20                  25                  30          


Glu Phe Leu Ala Leu Arg Asp Arg Leu His Ala Ala Glu Gln Glu Ser 
        35                  40                  45              


Leu Lys Arg Ser Lys Glu Leu Asn Leu Val Leu Asp Glu Ile Lys Arg 
    50                  55                  60                  


Ala Val Ser Glu Arg Gln Ala Leu Arg Asp Gly Asp Gly Asn Arg Thr 
65                  70                  75                  80  


Trp Gly Arg Leu Thr Gly Pro Pro Ile Glu Ala Val Glu Arg Leu Thr 
                85                  90                  95      


Pro Ala Arg Ala Ala Pro Ala His Arg Leu Pro Ser Pro Ala Thr Pro 
            100                 105                 110         


Ala Gly Gln Gly Glu Gln Ser Ala Ala Arg Gly Ala Arg Gly Pro Gly 
        115                 120                 125             


Pro His Arg Ser Val Gly Gly Asp Gly His Pro Glu Arg Ala Ala Arg 
    130                 135                 140                 


Gly Ala Leu Val Pro Asp 
145                 150 


<210>  8678
<211>  245
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8678

Xaa Gln Tyr Thr Ser Ala Val Thr Glu Asn Ile Lys Ala Leu Phe Pro 
1               5                   10                  15      


Thr Glu Ile His Ser Gly Leu Leu Glu Val Ile Ser Pro Ser Pro His 
            20                  25                  30          


Phe Tyr Pro Asp Phe Ser Arg Leu Arg Glu Ser Phe Gly Asp Pro Lys 
        35                  40                  45              


Glu Arg Val Arg Trp Arg Thr Lys Gln Asn Leu Asp Tyr Cys Phe Leu 
    50                  55                  60                  


Met Met Tyr Ala Gln Ser Lys Gly Ile Tyr Tyr Val Gln Leu Glu Asp 
65                  70                  75                  80  


Asp Ile Val Ala Lys Pro Asn Tyr Leu Ser Thr Met Lys Asn Phe Ala 
                85                  90                  95      


Leu Gln Gln Pro Ser Glu Asp Trp Met Ile Leu Glu Phe Ser Gln Leu 
            100                 105                 110         


Gly Phe Ile Gly Lys Met Phe Lys Ser Leu Asp Leu Ser Leu Ile Val 
        115                 120                 125             


Glu Phe Ile Leu Met Phe Tyr Arg Asp Lys Pro Ile Asp Trp Leu Leu 
    130                 135                 140                 


Asp His Ile Leu Trp Val Lys Val Cys Asn Pro Glu Lys Asp Ala Lys 
145                 150                 155                 160 


His Cys Asp Arg Gln Lys Ala Asn Leu Arg Ile Arg Phe Lys Pro Ser 
                165                 170                 175     


Leu Phe Gln His Val Gly Thr His Ser Ser Leu Ala Gly Lys Ile Gln 
            180                 185                 190         


Lys Leu Lys Asp Lys Asp Phe Gly Lys Gln Ala Leu Arg Lys Glu His 
        195                 200                 205             


Val Asn Pro Pro Ala Glu Trp Glu His Arg Ala Pro Gly Gly Gln Ala 
    210                 215                 220                 


Leu Gln His Val Cys Gly Gly Ala Ala Leu Arg Gln Pro Ser Val Arg 
225                 230                 235                 240 


Gln Gly Gly Pro Ala 
                245 


<210>  8679
<211>  307
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8679

Xaa Thr Ser Ala Val Thr Glu Asn Ile Lys Ala Leu Phe Pro Thr Glu 
1               5                   10                  15      


Ile His Ser Gly Leu Leu Glu Val Ile Ser Pro Ser Pro His Phe Tyr 
            20                  25                  30          


Pro Asp Phe Ser Arg Leu Arg Glu Ser Phe Gly Asp Pro Lys Glu Arg 
        35                  40                  45              


Val Arg Trp Arg Thr Lys Gln Asn Leu Asp Tyr Cys Phe Leu Met Met 
    50                  55                  60                  


Tyr Ala Gln Ser Lys Gly Ile Tyr Tyr Val Gln Leu Glu Asp Asp Ile 
65                  70                  75                  80  


Val Ala Lys Pro Asn Tyr Leu Ser Thr Met Lys Asn Phe Ala Leu Gln 
                85                  90                  95      


Gln Pro Ser Glu Asp Trp Met Ile Leu Glu Phe Ser Gln Leu Gly Phe 
            100                 105                 110         


Ile Ala Arg Gly His Ser Leu Leu Ala Gly Trp Gln Asp Pro Glu Thr 
        115                 120                 125             


Glu Gly Gln Arg Leu Trp Lys Ala Gly Ala Ala Glu Gly Ala Cys Glu 
    130                 135                 140                 


Pro Ala Ser Arg Gly Glu His Glu Pro Glu Asp Ile Pro Ala Leu His 
145                 150                 155                 160 


Pro Gly Glu Ser Leu Pro Ala Arg Gly Leu Leu Leu Gly Leu His Pro 
                165                 170                 175     


Cys Arg Gly Gly Leu His Pro Leu Pro Leu Leu Pro Thr Ser Lys Thr 
            180                 185                 190         


Gly Ala Val Leu Leu Pro Gln Trp Glu His Arg Ala Pro Gly Gly Gln 
        195                 200                 205             


Ala Leu Gln His Val Cys Gly Gly Ala Ala Leu Arg Gln Pro Ser Val 
    210                 215                 220                 


Arg Gln Gly Gly Pro Ala Gly Gly Pro His Arg His Pro Pro Val Pro 
225                 230                 235                 240 


Ser Glu Pro Arg Arg Leu Pro Pro Asp Arg Leu Leu Leu Gln Gly Ser 
                245                 250                 255     


Gly Arg Gly Arg Gly Gly Pro Ser Leu Arg Pro Ser Gly Ser Thr Ala 
            260                 265                 270         


Pro Leu Asp Pro Asp Gly Leu Pro Cys Val Gly Asp Ser Glu Arg Asp 
        275                 280                 285             


Leu Pro Glu Lys Gly Arg Leu Ser Cys Gly Leu Leu Arg Val Pro Cys 
    290                 295                 300                 


Gly Gln Pro 
305         


<210>  8680
<211>  113
<212>  PRT
<213>  Homo Sapiens

<400>  8680

Met Arg Thr Lys Gln Val Asn Leu Leu Ile Thr Leu Val Ala Val Ala 
1               5                   10                  15      


Leu Phe Ser Phe Ser Cys Phe Ser Ile Tyr Arg Ile Thr Gln Thr Ile 
            20                  25                  30          


Ser Phe Ala Leu Gly Ile Ser Thr Val Asn Arg Gly Asn Tyr Ser Tyr 
        35                  40                  45              


Leu Lys Gln Thr Leu Thr Ser Val Val Ser Arg Met Thr Leu Ser Gln 
    50                  55                  60                  


Glu Lys Asp Ser Val Val Ile Val Leu Val Ala Asp Ser Asn Glu Asp 
65                  70                  75                  80  


Tyr Leu His Ser Val Val Lys Met Ile Thr Lys Lys Phe Lys Arg Gln 
                85                  90                  95      


Val Arg Ser Gly Ser Leu Glu Val Ile Ser Ile Pro Ala Phe Leu Tyr 
            100                 105                 110         


Ser 
    


<210>  8681
<211>  166
<212>  PRT
<213>  Homo Sapiens

<400>  8681

Met Arg Thr Lys Gln Val Asn Leu Leu Ile Thr Leu Val Ala Val Ala 
1               5                   10                  15      


Leu Phe Ser Phe Ser Cys Phe Ser Ile Tyr Arg Ile Thr Gln Thr Asn 
            20                  25                  30          


Asn Gln Leu Ile Asn Cys Arg Asn His Ile Leu Glu Phe Lys Glu Asn 
        35                  40                  45              


Met Leu His Leu Arg Asn Lys Thr Glu Lys Asn Thr Gln Glu Met Met 
    50                  55                  60                  


Lys Val Leu Asn Arg Met Lys Tyr Glu Ile Thr Lys Arg Glu Ile Leu 
65                  70                  75                  80  


Ser Gly Asn Leu Gly Lys Leu Phe Arg Ser Glu Asp Leu Thr His Phe 
                85                  90                  95      


Val Arg Phe Phe Leu Met Phe Tyr Lys Glu Lys Pro Ile Asp Trp Leu 
            100                 105                 110         


Leu Asn Asp Ile Phe Gln Val Lys Val Cys Asp Ala Gly Glu Asp Leu 
        115                 120                 125             


Arg Asn Cys Met Lys Arg Lys Lys Gln Ile Arg Ile Gln Tyr Lys Pro 
    130                 135                 140                 


Ser Leu Phe Gln His Val Gly Ile His Ser Ser Phe Pro Arg Lys Glu 
145                 150                 155                 160 


Gln Tyr Glu Lys Lys Ile 
                165     


<210>  8682
<211>  375
<212>  PRT
<213>  Homo Sapiens

<400>  8682

Met Arg Thr Lys Gln Val Asn Leu Leu Ile Thr Leu Val Ala Val Ala 
1               5                   10                  15      


Leu Phe Ser Phe Ser Cys Phe Ser Ile Tyr Arg Ile Thr Gln Thr Asn 
            20                  25                  30          


Asn Gln Leu Ile Asn Cys Arg Asn His Ile Leu Glu Phe Lys Glu Asn 
        35                  40                  45              


Met Leu His Leu Arg Asn Lys Thr Glu Lys Asn Thr Gln Glu Met Met 
    50                  55                  60                  


Lys Val Leu Asn Arg Met Lys Tyr Glu Ile Thr Lys Arg Glu Ile Leu 
65                  70                  75                  80  


Ser Gly Asn Leu Val Ala Gln Lys Ala Asp Ile Leu Asn Lys Asn Glu 
                85                  90                  95      


Thr Val Ser Asn Thr Phe Glu Asp Leu Lys Phe Phe Phe Pro His Leu 
            100                 105                 110         


Arg Lys Glu Gly Arg Ile Tyr Pro Asp Val Ile Ile Gly Lys Gly Lys 
        115                 120                 125             


Thr Gly Val Ser Phe Ala Leu Gly Ile Ser Thr Val Asn Arg Gly Asn 
    130                 135                 140                 


Tyr Ser Tyr Leu Lys Gln Thr Leu Thr Ser Val Val Ser Arg Met Thr 
145                 150                 155                 160 


Leu Ser Gln Glu Lys Asp Ser Val Val Ile Val Leu Val Ala Asp Ser 
                165                 170                 175     


Asn Glu Asp Tyr Leu His Ser Val Val Lys Met Ile Thr Lys Lys Phe 
            180                 185                 190         


Lys Arg Gln Val Arg Ser Gly Ser Leu Glu Val Ile Ser Ile Pro Ala 
        195                 200                 205             


Phe Leu Tyr Ser Ser Met Leu Asn Ala Lys His Leu Ala Glu Ala Ser 
    210                 215                 220                 


Gln Lys Leu Ala Ser Trp Arg Ile Lys Gln Val Leu Asp Phe Cys Ile 
225                 230                 235                 240 


Leu Leu Leu Tyr Ala Gln Pro Lys Ala Lys Tyr Tyr Leu Gln Leu Glu 
                245                 250                 255     


Asp Asp Ile Ile Ala Lys Glu Met Tyr Phe Thr Lys Ile Thr Asp Phe 
            260                 265                 270         


Val Gly Asn Ile Ser Ser Asn Asn Trp Phe Phe Ile Glu Phe Ser Met 
        275                 280                 285             


Leu Gly Phe Ile Gly Lys Leu Phe Arg Ser Glu Asp Leu Thr His Phe 
    290                 295                 300                 


Val Arg Phe Phe Leu Met Phe Tyr Lys Glu Lys Pro Ile Asp Trp Leu 
305                 310                 315                 320 


Leu Asn Asp Ile Phe Gln Val Lys Val Cys Asp Ala Gly Glu Asp Leu 
                325                 330                 335     


Arg Asn Cys Met Lys Arg Lys Lys Gln Ile Arg Ile Gln Tyr Lys Pro 
            340                 345                 350         


Ser Leu Phe Gln His Val Gly Ile His Ser Ser Phe Pro Arg Lys Glu 
        355                 360                 365             


Gln Tyr Glu Lys Asp Val Tyr 
    370                 375 


<210>  8683
<211>  374
<212>  PRT
<213>  Homo Sapiens

<400>  8683

Met Arg Thr Lys Gln Val Asn Leu Leu Ile Thr Leu Val Ala Val Ala 
1               5                   10                  15      


Leu Phe Ser Phe Ser Cys Phe Ser Ile Tyr Arg Ile Thr Gln Thr Asn 
            20                  25                  30          


Asn Gln Leu Ile Asn Cys Arg Asn His Ile Leu Glu Phe Lys Glu Asn 
        35                  40                  45              


Met Leu His Leu Arg Asn Lys Thr Glu Lys Asn Thr Gln Glu Met Met 
    50                  55                  60                  


Lys Val Leu Asn Arg Met Lys Tyr Glu Ile Thr Lys Arg Glu Ile Leu 
65                  70                  75                  80  


Ser Gly Asn Leu Val Ala Gln Lys Ala Asp Ile Leu Asn Lys Asn Glu 
                85                  90                  95      


Thr Val Ser Asn Thr Phe Glu Asp Leu Lys Phe Phe Phe Pro His Leu 
            100                 105                 110         


Arg Lys Glu Gly Arg Ile Tyr Pro Asp Val Ile Ile Gly Lys Gly Lys 
        115                 120                 125             


Thr Gly Val Ser Phe Ala Leu Gly Ile Ser Thr Val Asn Arg Gly Asn 
    130                 135                 140                 


Tyr Ser Tyr Leu Lys Gln Thr Leu Thr Ser Val Val Ser Arg Met Thr 
145                 150                 155                 160 


Leu Ser Gln Glu Lys Asp Ser Val Val Ile Val Leu Val Ala Asp Ser 
                165                 170                 175     


Asn Glu Asp Tyr Leu His Ser Val Val Lys Met Ile Thr Lys Lys Phe 
            180                 185                 190         


Lys Arg Gln Val Arg Ser Gly Ser Leu Glu Val Ile Ser Ile Pro Ala 
        195                 200                 205             


Phe Leu Tyr Ser Ser Met Leu Asn Ala Lys His Leu Ala Glu Ala Ser 
    210                 215                 220                 


Gln Lys Leu Ala Ser Trp Arg Ile Lys Gln Val Leu Asp Phe Cys Ile 
225                 230                 235                 240 


Leu Leu Leu Tyr Ala Gln Pro Lys Ala Lys Tyr Tyr Leu Gln Leu Glu 
                245                 250                 255     


Asp Asp Ile Ile Ala Lys Glu Met Tyr Phe Thr Lys Ile Thr Asp Phe 
            260                 265                 270         


Val Gly Asn Ile Ser Ser Asn Asn Trp Phe Phe Ile Glu Phe Ser Met 
        275                 280                 285             


Leu Gly Phe Ile Gly Lys Leu Phe Arg Ser Glu Asp Leu Thr His Phe 
    290                 295                 300                 


Val Arg Phe Phe Leu Met Phe Tyr Lys Glu Lys Pro Ile Asp Trp Leu 
305                 310                 315                 320 


Leu Asn Asp Ile Phe Gln Val Lys Val Cys Asp Ala Gly Glu Asp Leu 
                325                 330                 335     


Arg Asn Cys Met Lys Arg Lys Lys Gln Ile Arg Ile Gln Tyr Lys Pro 
            340                 345                 350         


Ser Leu Phe Gln His Val Gly Ile His Ser Ser Phe Pro Arg Lys Glu 
        355                 360                 365             


Gln Tyr Glu Lys Lys Ile 
    370                 


<210>  8684
<211>  36
<212>  PRT
<213>  Homo Sapiens

<400>  8684

Met Arg Thr Lys Gln Val Asn Leu Leu Ile Thr Leu Val Ala Val Ala 
1               5                   10                  15      


Leu Phe Ser Phe Ser Cys Phe Ser Ile Tyr Arg Ile Thr Gln Thr Asn 
            20                  25                  30          


Ser Lys Gly Lys 
        35      


<210>  8685
<211>  91
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8685

Xaa Asn Ile Ser Ser Asn Asn Trp Phe Phe Ile Glu Phe Ser Met Leu 
1               5                   10                  15      


Gly Phe Ile Gly Lys Leu Phe Arg Ser Glu Asp Leu Thr His Phe Val 
            20                  25                  30          


Arg Phe Phe Leu Met Phe Tyr Lys Glu Lys Pro Ile Asp Trp Leu Leu 
        35                  40                  45              


Asn Asp Ile Phe Gln Arg Asn Cys Met Lys Arg Lys Lys Gln Ile Arg 
    50                  55                  60                  


Ile Gln Tyr Lys Pro Ser Leu Phe Gln His Val Gly Ile His Ser Ser 
65                  70                  75                  80  


Phe Pro Arg Lys Glu Gln Tyr Glu Lys Lys Ile 
                85                  90      


<210>  8686
<211>  283
<212>  PRT
<213>  Homo Sapiens

<400>  8686

Met Glu Thr Gly Pro Glu Asp Pro Ser Ser Met Pro Glu Glu Ser Ser 
1               5                   10                  15      


Pro Arg Arg Thr Pro Gln Ser Ile Pro Tyr Gln Asp Leu Pro His Leu 
            20                  25                  30          


Val Asn Ala Asp Gly Gln Tyr Leu Phe Cys Arg Tyr Trp Lys Pro Thr 
        35                  40                  45              


Gly Thr Pro Lys Ala Leu Ile Phe Val Ser His Gly Ala Gly Glu His 
    50                  55                  60                  


Ser Gly Arg Tyr Glu Glu Leu Ala Arg Met Leu Met Gly Leu Asp Leu 
65                  70                  75                  80  


Leu Val Phe Ala His Asp His Val Gly His Gly Gln Ser Glu Gly Glu 
                85                  90                  95      


Arg Met Val Val Ser Asp Phe His Val Phe Val Arg Asp Val Leu Gln 
            100                 105                 110         


His Val Asp Ser Met Gln Lys Asp Tyr Pro Gly Leu Pro Val Phe Leu 
        115                 120                 125             


Leu Gly His Ser Met Gly Gly Ala Ile Ala Ile Leu Thr Ala Ala Glu 
    130                 135                 140                 


Arg Pro Gly His Phe Ala Gly Met Val Leu Ile Ser Pro Leu Val Leu 
145                 150                 155                 160 


Ala Asn Pro Glu Ser Ala Thr Thr Phe Lys Val Asp Ile Tyr Asn Ser 
                165                 170                 175     


Asp Pro Leu Ile Cys Arg Ala Gly Leu Lys Val Cys Phe Gly Ile Gln 
            180                 185                 190         


Leu Leu Asn Ala Val Ser Arg Val Glu Arg Ala Leu Pro Lys Leu Thr 
        195                 200                 205             


Val Pro Phe Leu Leu Leu Gln Gly Ser Ala Asp Arg Leu Cys Asp Ser 
    210                 215                 220                 


Lys Gly Ala Tyr Leu Leu Met Glu Leu Ala Lys Ser Gln Asp Lys Thr 
225                 230                 235                 240 


Leu Lys Ile Tyr Glu Gly Ala Tyr His Val Leu His Lys Glu Leu Pro 
                245                 250                 255     


Glu Val Thr Asn Ser Val Phe His Glu Ile Asn Met Trp Val Ser Gln 
            260                 265                 270         


Arg Thr Ala Thr Ala Gly Thr Ala Ser Pro Pro 
        275                 280             


<210>  8687
<211>  313
<212>  PRT
<213>  Homo Sapiens

<400>  8687

Met Glu Thr Gly Pro Glu Asp Pro Ser Ser Met Pro Glu Glu Ser Ser 
1               5                   10                  15      


Pro Arg Arg Thr Pro Gln Ser Ile Pro Tyr Gln Asp Leu Pro His Leu 
            20                  25                  30          


Val Asn Ala Asp Gly Gln Tyr Leu Phe Cys Arg Tyr Trp Lys Pro Thr 
        35                  40                  45              


Gly Thr Pro Lys Ala Leu Ile Phe Val Ser His Gly Ala Gly Glu His 
    50                  55                  60                  


Ser Gly Arg Tyr Glu Glu Leu Ala Arg Met Leu Met Gly Leu Asp Leu 
65                  70                  75                  80  


Leu Val Phe Ala His Asp His Val Gly His Gly Gln Ser Glu Gly Glu 
                85                  90                  95      


Arg Met Val Val Ser Asp Phe His Val Phe Val Arg Asp Val Leu Gln 
            100                 105                 110         


His Val Asp Ser Met Gln Lys Asp Tyr Pro Gly Leu Pro Val Phe Leu 
        115                 120                 125             


Leu Gly His Ser Met Gly Gly Ala Ile Ala Ile Leu Thr Ala Ala Glu 
    130                 135                 140                 


Arg Pro Gly His Phe Ala Gly Met Val Leu Ile Ser Pro Leu Val Leu 
145                 150                 155                 160 


Ala Asn Pro Glu Ser Ala Thr Thr Phe Lys Val Leu Ala Ala Lys Val 
                165                 170                 175     


Leu Asn Leu Val Leu Pro Asn Leu Ser Leu Gly Pro Ile Asp Ser Ser 
            180                 185                 190         


Val Leu Ser Arg Asn Lys Thr Glu Val Asp Ile Tyr Asn Ser Asp Pro 
        195                 200                 205             


Leu Ile Cys Arg Ala Gly Leu Lys Val Cys Phe Gly Ile Gln Leu Leu 
    210                 215                 220                 


Asn Ala Val Ser Arg Val Glu Arg Ala Leu Pro Lys Leu Thr Val Pro 
225                 230                 235                 240 


Phe Leu Leu Leu Gln Gly Ser Ala Asp Arg Leu Cys Asp Ser Lys Gly 
                245                 250                 255     


Ala Tyr Leu Leu Met Glu Leu Ala Lys Ser Gln Asp Lys Thr Leu Lys 
            260                 265                 270         


Ile Tyr Glu Gly Ala Tyr His Val Leu His Lys Glu Leu Pro Glu Val 
        275                 280                 285             


Thr Asn Ser Val Phe His Glu Ile Asn Met Trp Val Ser Gln Arg Thr 
    290                 295                 300                 


Ala Thr Ala Gly Thr Ala Ser Pro Pro 
305                 310             


<210>  8688
<211>  89
<212>  PRT
<213>  Homo Sapiens

<400>  8688

Met Leu Met Gly Leu Asp Leu Leu Val Phe Ala His Asp His Val Gly 
1               5                   10                  15      


His Gly Gln Ser Glu Gly Glu Arg Met Val Val Ser Asp Phe His Val 
            20                  25                  30          


Phe Val Arg Asp Val Leu Gln His Val Asp Ser Met Gln Lys Asp Tyr 
        35                  40                  45              


Pro Gly Leu Pro Val Phe Leu Leu Gly His Ser Met Gly Gly Ala Ile 
    50                  55                  60                  


Ala Ile Leu Thr Ala Ala Glu Arg Pro Gly His Phe Ala Gly Met Val 
65                  70                  75                  80  


Leu Ile Ser Pro Leu Val Leu Ala Asn 
                85                  


<210>  8689
<211>  77
<212>  PRT
<213>  Homo Sapiens

<400>  8689

Met Pro Glu Glu Ser Ser Pro Arg Arg Thr Pro Gln Ser Ile Pro Tyr 
1               5                   10                  15      


Gln Asp Leu Pro His Leu Val Asn Ala Asp Gly Gln Tyr Leu Phe Cys 
            20                  25                  30          


Arg Tyr Trp Lys Pro Thr Gly Thr Pro Lys Ala Leu Ile Phe Val Ser 
        35                  40                  45              


His Gly Ala Gly Glu His Ser Gly Arg Tyr Glu Glu Leu Ala Arg Met 
    50                  55                  60                  


Leu Met Gly Leu Asp Leu Leu Val Phe Ala His Asp His 
65                  70                  75          


<210>  8690
<211>  303
<212>  PRT
<213>  Homo Sapiens

<400>  8690

Met Pro Glu Glu Ser Ser Pro Arg Arg Thr Pro Gln Ser Ile Pro Tyr 
1               5                   10                  15      


Gln Asp Leu Pro His Leu Val Asn Ala Asp Gly Gln Tyr Leu Phe Cys 
            20                  25                  30          


Arg Tyr Trp Lys Pro Thr Gly Thr Pro Lys Ala Leu Ile Phe Val Ser 
        35                  40                  45              


His Gly Ala Gly Glu His Ser Gly Arg Tyr Glu Glu Leu Ala Arg Met 
    50                  55                  60                  


Leu Met Gly Leu Asp Leu Leu Val Phe Ala His Asp His Val Gly His 
65                  70                  75                  80  


Gly Gln Ser Glu Gly Glu Arg Met Val Val Ser Asp Phe His Val Phe 
                85                  90                  95      


Val Arg Asp Val Leu Gln His Val Asp Ser Met Gln Lys Asp Tyr Pro 
            100                 105                 110         


Gly Leu Pro Val Phe Leu Leu Gly His Ser Met Gly Gly Ala Ile Ala 
        115                 120                 125             


Ile Leu Thr Ala Ala Glu Arg Pro Gly His Phe Ala Gly Met Val Leu 
    130                 135                 140                 


Ile Ser Pro Leu Val Leu Ala Asn Pro Glu Ser Ala Thr Thr Phe Lys 
145                 150                 155                 160 


Val Leu Ala Ala Lys Val Leu Asn Leu Val Leu Pro Asn Leu Ser Leu 
                165                 170                 175     


Gly Pro Ile Asp Ser Ser Val Leu Ser Arg Asn Lys Thr Glu Val Asp 
            180                 185                 190         


Ile Tyr Asn Ser Asp Pro Leu Ile Cys Arg Ala Gly Leu Lys Val Cys 
        195                 200                 205             


Phe Gly Ile Gln Leu Leu Asn Ala Val Ser Arg Val Glu Arg Ala Leu 
    210                 215                 220                 


Pro Lys Leu Thr Val Pro Phe Leu Leu Leu Gln Gly Ser Ala Asp Arg 
225                 230                 235                 240 


Leu Cys Asp Ser Lys Gly Ala Tyr Leu Leu Met Glu Leu Ala Lys Ser 
                245                 250                 255     


Gln Asp Lys Thr Leu Lys Ile Tyr Glu Gly Ala Tyr His Val Leu His 
            260                 265                 270         


Lys Glu Leu Pro Glu Val Thr Asn Ser Val Phe His Glu Ile Asn Met 
        275                 280                 285             


Trp Val Ser Gln Arg Thr Ala Thr Ala Gly Thr Ala Ser Pro Pro 
    290                 295                 300             


<210>  8691
<211>  303
<212>  PRT
<213>  Homo Sapiens

<400>  8691

Met Pro Glu Glu Ser Ser Pro Arg Arg Thr Pro Gln Ser Ile Pro Tyr 
1               5                   10                  15      


Gln Asp Leu Pro His Leu Val Asn Ala Asp Gly Gln Tyr Leu Phe Cys 
            20                  25                  30          


Arg Tyr Trp Lys Pro Thr Gly Thr Pro Lys Ala Leu Ile Phe Val Ser 
        35                  40                  45              


His Gly Ala Gly Glu His Ser Gly Arg Tyr Glu Glu Leu Ala Arg Met 
    50                  55                  60                  


Leu Met Gly Leu Asp Leu Leu Val Phe Ala His Asp His Val Gly His 
65                  70                  75                  80  


Gly Gln Ser Glu Gly Glu Arg Met Val Val Ser Asp Phe His Val Phe 
                85                  90                  95      


Val Arg Asp Val Leu Gln His Val Asp Ser Met Gln Lys Asp Tyr Pro 
            100                 105                 110         


Gly Leu Pro Val Phe Leu Leu Gly His Ser Met Gly Gly Ala Ile Ala 
        115                 120                 125             


Ile Leu Thr Ala Ala Glu Arg Pro Gly His Phe Ala Gly Met Val Leu 
    130                 135                 140                 


Ile Ser Pro Leu Val Leu Ala Asn Pro Glu Ser Ala Thr Thr Phe Lys 
145                 150                 155                 160 


Val Leu Ala Ala Lys Val Leu Asn Leu Val Leu Pro Asn Leu Ser Leu 
                165                 170                 175     


Gly Pro Ile Asp Ser Ser Val Leu Ser Arg Asn Lys Thr Glu Val Asp 
            180                 185                 190         


Ile Tyr Asn Ser Asp Pro Leu Ile Cys Arg Ala Gly Leu Lys Val Cys 
        195                 200                 205             


Phe Gly Ile Gln Leu Leu Asn Ala Val Ser Arg Val Glu Arg Ala Leu 
    210                 215                 220                 


Pro Lys Leu Thr Val Pro Phe Leu Leu Leu Gln Gly Ser Ala Asp Arg 
225                 230                 235                 240 


Leu Cys Asp Ser Lys Gly Ala Tyr Leu Leu Met Glu Leu Ala Lys Ser 
                245                 250                 255     


Gln Asp Lys Thr Leu Lys Ile Tyr Glu Gly Ala Tyr His Val Leu His 
            260                 265                 270         


Lys Glu Leu Pro Glu Val Thr Asn Ser Val Phe His Glu Ile Asn Met 
        275                 280                 285             


Trp Val Ser Gln Arg Thr Ala Thr Ala Gly Thr Ala Ser Pro Pro 
    290                 295                 300             


<210>  8692
<211>  277
<212>  PRT
<213>  Homo Sapiens

<400>  8692

Met Gln Thr Arg Phe Arg Arg Ile Phe Pro Trp Lys Asp Ala Ser Thr 
1               5                   10                  15      


Lys Arg Met Pro Glu Phe Ile His Phe Ser Pro Leu Lys Pro Tyr Lys 
            20                  25                  30          


Gly Arg Glu Trp Glu Lys Ala Gly Ser Glu His Val Leu Glu Thr His 
        35                  40                  45              


Leu Leu Pro Val Gly His Gly Gln Ser Glu Gly Glu Arg Met Val Val 
    50                  55                  60                  


Ser Asp Phe His Val Phe Val Arg Asp Val Leu Gln His Val Asp Ser 
65                  70                  75                  80  


Met Gln Lys Asp Tyr Pro Gly Leu Pro Val Phe Leu Leu Gly His Ser 
                85                  90                  95      


Met Gly Gly Ala Ile Ala Ile Leu Thr Ala Ala Glu Arg Pro Gly His 
            100                 105                 110         


Phe Ala Gly Met Val Leu Ile Ser Pro Leu Val Leu Ala Asn Pro Glu 
        115                 120                 125             


Ser Ala Thr Thr Phe Lys Val Leu Ala Ala Lys Val Leu Asn Leu Val 
    130                 135                 140                 


Leu Pro Asn Leu Ser Leu Gly Pro Ile Asp Ser Ser Val Leu Ser Arg 
145                 150                 155                 160 


Asn Lys Thr Glu Val Asp Ile Tyr Asn Ser Asp Pro Leu Ile Cys Arg 
                165                 170                 175     


Ala Gly Leu Lys Val Cys Phe Gly Ile Gln Leu Leu Asn Ala Val Ser 
            180                 185                 190         


Arg Val Glu Arg Ala Leu Pro Lys Leu Thr Val Pro Phe Leu Leu Leu 
        195                 200                 205             


Gln Gly Ser Ala Asp Arg Leu Cys Asp Ser Lys Gly Ala Tyr Leu Leu 
    210                 215                 220                 


Met Glu Leu Ala Lys Ser Gln Asp Lys Thr Leu Lys Ile Tyr Glu Gly 
225                 230                 235                 240 


Ala Tyr His Val Leu His Lys Glu Leu Pro Glu Val Thr Asn Ser Val 
                245                 250                 255     


Phe His Glu Ile Asn Met Trp Val Ser Gln Arg Thr Ala Thr Ala Gly 
            260                 265                 270         


Thr Ala Ser Pro Pro 
        275         


<210>  8693
<211>  197
<212>  PRT
<213>  Homo Sapiens

<400>  8693

Pro Val Gly His Gly Gln Ser Glu Gly Glu Arg Met Val Val Ser Asp 
1               5                   10                  15      


Phe His Val Phe Val Arg Asp Val Leu Gln His Val Asp Ser Met Gln 
            20                  25                  30          


Lys Asp Tyr Pro Gly Leu Pro Val Phe Leu Leu Gly His Ser Met Gly 
        35                  40                  45              


Gly Ala Ile Ala Ile Leu Thr Ala Ala Glu Arg Pro Gly His Phe Ala 
    50                  55                  60                  


Gly Met Val Leu Ile Ser Pro Leu Val Leu Ala Asn Pro Glu Ser Ala 
65                  70                  75                  80  


Thr Thr Phe Lys Val Asp Ile Tyr Asn Ser Asp Pro Leu Ile Cys Arg 
                85                  90                  95      


Ala Gly Leu Lys Val Cys Phe Gly Ile Gln Leu Leu Asn Ala Val Ser 
            100                 105                 110         


Arg Val Glu Arg Ala Leu Pro Lys Leu Thr Val Pro Phe Leu Leu Leu 
        115                 120                 125             


Gln Gly Ser Ala Asp Arg Leu Cys Asp Ser Lys Gly Ala Tyr Leu Leu 
    130                 135                 140                 


Met Glu Leu Ala Lys Ser Gln Asp Lys Thr Leu Lys Ile Tyr Glu Gly 
145                 150                 155                 160 


Ala Tyr His Val Leu His Lys Glu Leu Pro Glu Val Thr Asn Ser Val 
                165                 170                 175     


Phe His Glu Ile Asn Met Trp Val Ser Gln Arg Thr Ala Thr Ala Gly 
            180                 185                 190         


Thr Ala Ser Pro Pro 
        195         


<210>  8694
<211>  155
<212>  PRT
<213>  Homo Sapiens

<400>  8694

Pro Val Gly His Gly Gln Ser Glu Gly Glu Arg Met Val Val Ser Asp 
1               5                   10                  15      


Phe His Val Phe Val Arg Asp Val Leu Gln His Val Asp Ser Met Gln 
            20                  25                  30          


Lys Asp Tyr Pro Gly Leu Pro Val Phe Leu Leu Gly His Ser Met Gly 
        35                  40                  45              


Gly Ala Ile Ala Ile Leu Thr Ala Ala Glu Arg Pro Gly His Phe Ala 
    50                  55                  60                  


Gly Met Val Leu Ile Ser Pro Leu Val Leu Ala Asn Pro Glu Ser Ala 
65                  70                  75                  80  


Thr Thr Phe Lys Val Leu Ala Ala Lys Val Leu Asn Leu Val Leu Pro 
                85                  90                  95      


Asn Leu Ser Leu Gly Pro Ile Asp Ser Ser Val Leu Ser Arg Asn Lys 
            100                 105                 110         


Thr Glu Ile Tyr Glu Gly Ala Tyr His Val Leu His Lys Glu Leu Pro 
        115                 120                 125             


Glu Val Thr Asn Ser Val Phe His Glu Ile Asn Met Trp Val Ser Gln 
    130                 135                 140                 


Arg Thr Ala Thr Ala Gly Thr Ala Ser Pro Pro 
145                 150                 155 


<210>  8695
<211>  209
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8695

Xaa Leu Gln Gly Gly Ala Ile Ala Ile Leu Thr Ala Ala Glu Arg Pro 
1               5                   10                  15      


Gly His Phe Ala Gly Met Val Leu Ile Ser Pro Leu Val Leu Ala Asn 
            20                  25                  30          


Pro Glu Ser Ala Thr Thr Phe Lys Asp Tyr Ser Arg Ile Leu Lys His 
        35                  40                  45              


Leu Met Glu Lys Ala Ser Arg Met Leu Lys Phe Trp Ile Pro Arg Pro 
    50                  55                  60                  


Phe Trp Val Leu Ala Ala Lys Val Leu Asn Leu Val Leu Pro Asn Leu 
65                  70                  75                  80  


Ser Leu Gly Pro Ile Asp Ser Ser Val Leu Ser Arg Asn Lys Thr Glu 
                85                  90                  95      


Val Asp Ile Tyr Asn Ser Asp Pro Leu Ile Cys Arg Ala Gly Leu Lys 
            100                 105                 110         


Val Cys Phe Gly Ile Gln Leu Leu Asn Ala Val Ser Arg Val Glu Arg 
        115                 120                 125             


Ala Leu Pro Lys Leu Thr Val Pro Phe Leu Leu Leu Gln Gly Ser Ala 
    130                 135                 140                 


Asp Arg Leu Cys Asp Ser Lys Gly Ala Tyr Leu Leu Met Glu Leu Ala 
145                 150                 155                 160 


Lys Ser Gln Asp Lys Thr Leu Lys Ile Tyr Glu Gly Ala Tyr His Val 
                165                 170                 175     


Leu His Lys Glu Leu Pro Glu Val Thr Asn Ser Val Phe His Glu Ile 
            180                 185                 190         


Asn Met Trp Val Ser Gln Arg Thr Ala Thr Ala Gly Thr Ala Ser Pro 
        195                 200                 205             


Pro 
    


<210>  8696
<211>  103
<212>  PRT
<213>  Homo Sapiens

<400>  8696

Met Lys Ser Leu Ile Leu Leu Ala Ile Leu Ala Ala Leu Ala Val Val 
1               5                   10                  15      


Thr Leu Cys Tyr Glu Ser His Glu Ser Met Glu Ser Tyr Glu Leu Asn 
            20                  25                  30          


Pro Phe Ile Asn Arg Arg Asn Ala Asn Thr Phe Ile Ser Pro Gln Gln 
        35                  40                  45              


Arg Trp Arg Ala Lys Val Gln Glu Arg Ile Arg Glu Arg Ser Lys Pro 
    50                  55                  60                  


Val His Glu Leu Asn Arg Glu Ala Cys Asp Asp Tyr Arg Leu Cys Glu 
65                  70                  75                  80  


Arg Tyr Ala Met Val Tyr Gly Tyr Asn Ala Ala Tyr Asn Arg Tyr Phe 
                85                  90                  95      


Arg Lys Arg Arg Gly Thr Lys 
            100             


<210>  8697
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  8697

Met Lys Ser Leu Ile Leu Leu Ala Ile Leu Ala Ala Leu Ala Val Val 
1               5                   10                  15      


Thr Leu Cys Tyr Gly Glu Trp Gln Lys Glu Glu Asn Phe Gly Phe Asp 
            20                  25                  30          


Ile Val Ser Val Leu Ser Leu Asn Trp His Arg Ala Gln Glu Ser His 
        35                  40                  45              


Glu Ser Met Glu Ser Tyr Glu Leu Asn Pro Phe Ile Asn Arg Arg Asn 
    50                  55                  60                  


Ala Asn Thr Phe Ile Ser Pro Gln Gln Arg Trp Arg Ala Lys Val Gln 
65                  70                  75                  80  


Glu Arg Ile Arg Glu Arg Ser Lys Pro Val His Glu Leu Asn Arg Glu 
                85                  90                  95      


Ala Cys Asp Asp Tyr Arg Leu Cys Glu Arg Tyr Ala Met Val Tyr Gly 
            100                 105                 110         


Tyr Asn Ala Ala Tyr Asn Arg Tyr Phe Arg Lys Arg Arg Gly Thr Lys 
        115                 120                 125             


<210>  8698
<211>  74
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8698

Xaa Ser His Glu Ser Met Glu Ser Tyr Glu Leu Arg Ser Glu Asn Ala 
1               5                   10                  15      


Leu Ser Leu Ser Thr Ser Ser Ile Gly Lys Pro Val Met Thr Thr Asp 
            20                  25                  30          


Phe Ala Asn Ala Thr Pro Trp Phe Met Asp Thr Met Leu Pro Ile Ile 
        35                  40                  45              


Ala Thr Ser Gly Ser Ala Glu Gly Pro Asn Glu Thr Glu Gly Arg Lys 
    50                  55                  60                  


Lys Ile Ser Phe Phe Leu Glu Ala Gly Thr 
65                  70                  


<210>  8699
<211>  77
<212>  PRT
<213>  Homo Sapiens

<400>  8699

Met Ala Gly Asn Ser Ile Leu Leu Ala Ala Val Ser Ile Leu Ser Ala 
1               5                   10                  15      


Cys Gln Gln Ser Tyr Phe Ala Leu Gln Val Gly Lys Ala Arg Leu Lys 
            20                  25                  30          


Tyr Lys Val Thr Pro Pro Ala Val Thr Gly Ser Pro Glu Phe Glu Arg 
        35                  40                  45              


Val Phe Arg Ala His Phe Cys Tyr Leu Ser Gly Ser Gly Val His Ile 
    50                  55                  60                  


Trp Pro Ser Pro Ile Leu Leu Gly Ile Phe Arg Ser Cys 
65                  70                  75          


<210>  8700
<211>  147
<212>  PRT
<213>  Homo Sapiens

<400>  8700

Met Ala Gly Asn Ser Ile Leu Leu Ala Ala Val Ser Ile Leu Ser Ala 
1               5                   10                  15      


Cys Gln Gln Ser Tyr Phe Ala Leu Gln Val Gly Lys Ala Arg Leu Lys 
            20                  25                  30          


Tyr Lys Val Thr Pro Pro Ala Val Thr Gly Ser Pro Glu Phe Glu Arg 
        35                  40                  45              


Val Phe Arg Ala Gln Gln Asn Cys Val Glu Phe Tyr Pro Ile Phe Ile 
    50                  55                  60                  


Ile Thr Leu Trp Met Ala Gly Trp Tyr Phe Asn Gln Val Phe Ala Thr 
65                  70                  75                  80  


Cys Leu Gly Leu Val Tyr Ile Tyr Gly Arg His Leu Tyr Phe Trp Gly 
                85                  90                  95      


Tyr Ser Glu Ala Ala Lys Lys Arg Ile Thr Gly Phe Arg Leu Ser Leu 
            100                 105                 110         


Gly Ile Leu Ala Leu Leu Thr Leu Leu Gly Ala Leu Gly Ile Ala Asn 
        115                 120                 125             


Ser Phe Leu Asp Glu Tyr Leu Asp Leu Asn Ile Ala Lys Lys Leu Arg 
    130                 135                 140                 


Arg Gln Phe 
145         


<210>  8701
<211>  147
<212>  PRT
<213>  Homo Sapiens

<400>  8701

Met Ala Gly Asn Ser Ile Leu Leu Ala Ala Val Ser Ile Leu Ser Ala 
1               5                   10                  15      


Cys Gln Gln Ser Tyr Phe Ala Leu Gln Val Gly Lys Ala Arg Leu Lys 
            20                  25                  30          


Tyr Lys Val Thr Pro Pro Ala Val Thr Gly Ser Pro Glu Phe Glu Arg 
        35                  40                  45              


Val Phe Arg Ala Gln Gln Asn Cys Val Glu Phe Tyr Pro Ile Phe Ile 
    50                  55                  60                  


Ile Thr Leu Trp Met Ala Gly Trp Tyr Phe Asn Gln Val Phe Ala Thr 
65                  70                  75                  80  


Cys Leu Gly Leu Val Tyr Ile Tyr Gly Arg His Leu Tyr Phe Trp Gly 
                85                  90                  95      


Tyr Ser Glu Ala Ala Lys Lys Arg Ile Thr Gly Phe Arg Leu Ser Leu 
            100                 105                 110         


Gly Ile Leu Ala Leu Leu Thr Leu Leu Gly Ala Leu Gly Ile Ala Asn 
        115                 120                 125             


Ser Phe Leu Asp Glu Tyr Leu Asp Leu Asn Ile Ala Lys Lys Leu Arg 
    130                 135                 140                 


Arg Gln Phe 
145         


<210>  8702
<211>  147
<212>  PRT
<213>  Homo Sapiens

<400>  8702

Met Ala Gly Asn Ser Ile Leu Leu Ala Ala Val Ser Ile Leu Ser Ala 
1               5                   10                  15      


Cys Gln Gln Ser Tyr Phe Ala Leu Gln Val Gly Lys Ala Arg Leu Lys 
            20                  25                  30          


Tyr Lys Val Thr Pro Pro Ala Val Thr Gly Ser Pro Glu Phe Glu Arg 
        35                  40                  45              


Val Phe Arg Ala Gln Gln Asn Cys Val Glu Phe Tyr Pro Ile Phe Ile 
    50                  55                  60                  


Ile Thr Leu Trp Met Ala Gly Trp Tyr Phe Asn Gln Val Phe Ala Thr 
65                  70                  75                  80  


Cys Leu Gly Leu Val Tyr Ile Tyr Gly Arg His Leu Tyr Phe Trp Gly 
                85                  90                  95      


Tyr Ser Glu Ala Ala Lys Lys Arg Ile Thr Gly Phe Arg Leu Ser Leu 
            100                 105                 110         


Gly Ile Leu Ala Leu Leu Thr Leu Leu Gly Ala Leu Gly Ile Ala Asn 
        115                 120                 125             


Ser Phe Leu Asp Glu Tyr Leu Asp Leu Asn Ile Ala Lys Lys Leu Arg 
    130                 135                 140                 


Arg Gln Phe 
145         


<210>  8703
<211>  46
<212>  PRT
<213>  Homo Sapiens

<400>  8703

Met Ala Arg Ser Leu Val Cys Leu Gly Val Ile Ile Leu Leu Ser Ala 
1               5                   10                  15      


Phe Ser Gly Pro Gly Val Arg Gly Gly Pro Met Pro Lys Leu Ala Asp 
            20                  25                  30          


Arg Lys Leu Cys Ala Asp Gln Glu Cys Ser His Pro Ile Ser 
        35                  40                  45      


<210>  8704
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  8704

Met Ala Arg Ser Leu Val Cys Leu Gly Val Ile Ile Leu Leu Ser Ala 
1               5                   10                  15      


Phe Ser Gly Pro Gly Val Arg Gly Gly Pro Met Pro Lys Leu Ala Asp 
            20                  25                  30          


Arg Lys Leu Cys Ala Asp Gln Glu Cys Ser His Pro Ile Ser Met Ala 
        35                  40                  45              


Val Ala Leu Gln Asp Tyr Met Ala Pro Asp Cys Arg Phe Leu Thr Ile 
    50                  55                  60                  


His Arg Gly Gln Val Val Tyr Val Phe Ser Lys Leu Lys Gly Arg Gly 
65                  70                  75                  80  


Arg Leu Phe Trp Gly Gly Ser Val Gln Gly Asp Tyr Tyr Gly Asp Leu 
                85                  90                  95      


Ala Ala Arg Leu Gly Tyr Phe Pro Ser Ser Ile Val Arg Glu Asp Gln 
            100                 105                 110         


Thr Leu Lys Pro Gly Lys Val Asp Val Lys Thr Asp Lys Trp Asp Phe 
        115                 120                 125             


Tyr Cys Gln 
    130     


<210>  8705
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  8705

Met Ala Arg Ser Leu Val Cys Leu Gly Val Ile Ile Leu Leu Ser Ala 
1               5                   10                  15      


Phe Ser Gly Pro Gly Val Arg Gly Gly Pro Met Pro Lys Leu Ala Asp 
            20                  25                  30          


Arg Lys Leu Cys Ala Asp Gln Glu Cys Ser His Pro Ile Ser Met Ala 
        35                  40                  45              


Val Ala Leu Gln Asp Tyr Met Ala Pro Asp Cys Arg Phe Leu Thr Ile 
    50                  55                  60                  


His Arg Gly Gln Val Val Tyr Val Phe Ser Lys Leu Lys Gly Arg Gly 
65                  70                  75                  80  


Arg Leu Phe Trp Gly Gly Ser Val Gln Gly Asp Tyr Tyr Gly Asp Leu 
                85                  90                  95      


Ala Ala Arg Leu Gly Tyr Phe Pro Ser Ser Ile Val Arg Glu Asp Gln 
            100                 105                 110         


Thr Leu Lys Pro Gly Lys Val Asp Val Lys Thr Asp Lys Trp Asp Phe 
        115                 120                 125             


Tyr Cys Gln 
    130     


<210>  8706
<211>  131
<212>  PRT
<213>  Homo Sapiens

<400>  8706

Met Ala Arg Ser Leu Val Cys Leu Gly Val Ile Ile Leu Leu Ser Ala 
1               5                   10                  15      


Phe Ser Gly Pro Gly Val Arg Gly Gly Pro Met Pro Lys Leu Ala Asp 
            20                  25                  30          


Arg Lys Leu Cys Ala Asp Gln Glu Cys Ser His Pro Ile Ser Met Ala 
        35                  40                  45              


Val Ala Leu Gln Asp Tyr Met Ala Pro Asp Cys Arg Phe Leu Thr Ile 
    50                  55                  60                  


His Arg Gly Gln Val Val Tyr Val Phe Ser Lys Leu Lys Gly Arg Gly 
65                  70                  75                  80  


Arg Leu Phe Trp Gly Gly Ser Val Gln Gly Asp Tyr Tyr Gly Asp Leu 
                85                  90                  95      


Ala Ala Arg Leu Gly Tyr Phe Pro Ser Ser Ile Val Arg Glu Asp Gln 
            100                 105                 110         


Thr Leu Lys Pro Gly Lys Val Asp Val Lys Thr Asp Lys Trp Asp Phe 
        115                 120                 125             


Tyr Cys Gln 
    130     


<210>  8707
<211>  95
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8707

Xaa Arg Ser Leu Val Cys Leu Gly Val Ile Ile Leu Leu Ser Ala Phe 
1               5                   10                  15      


Ser Gly Pro Gly Val Arg Gly Gly Pro Met Pro Lys Leu Ala Asp Arg 
            20                  25                  30          


Lys Leu Cys Ala Asp Gln Glu Cys Ser His Pro Ile Ser Met Ala Val 
        35                  40                  45              


Ala Leu Gln Asp Tyr Met Ala Pro Asp Cys Arg Phe Leu Thr Ile His 
    50                  55                  60                  


Arg Gly Gln Val Val Phe Arg Glu Ile Thr Met Glu Ile Trp Leu Leu 
65                  70                  75                  80  


Ala Trp Ala Ile Ser Pro Val Ala Leu Ser Glu Arg Thr Arg Pro 
                85                  90                  95  


<210>  8708
<211>  58
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8708

Xaa Ser Leu Val Cys Leu Gly Val Ile Ile Leu Leu Ser Ala Phe Ser 
1               5                   10                  15      


Gly Pro Gly Val Arg Gly Gly Pro Met Pro Lys Leu Ala Asp Arg Lys 
            20                  25                  30          


Leu Cys Ala Asp Gln Glu Cys Ser Arg Ser Gly Arg Leu Leu Trp Arg 
        35                  40                  45              


Ser Gly Cys Ser Pro Gly Leu Phe Pro Gln 
    50                  55              


<210>  8709
<211>  1412
<212>  PRT
<213>  Homo Sapiens

<400>  8709

Met Ala Lys Phe Gly Val His Arg Ile Leu Leu Leu Ala Ile Ser Leu 
1               5                   10                  15      


Thr Lys Cys Leu Glu Ser Thr Lys Leu Leu Ala Asp Leu Lys Lys Cys 
            20                  25                  30          


Gly Asp Leu Glu Cys Glu Ala Leu Ile Asn Arg Val Ser Ala Met Arg 
        35                  40                  45              


Asp Tyr Arg Gly Pro Asp Cys Arg Tyr Leu Asn Phe Thr Lys Gly Glu 
    50                  55                  60                  


Glu Ile Ser Val Tyr Val Lys Leu Ala Gly Glu Arg Glu Asp Leu Trp 
65                  70                  75                  80  


Ala Gly Ser Lys Gly Lys Glu Phe Gly Tyr Phe Pro Arg Asp Ala Val 
                85                  90                  95      


Gln Ile Glu Glu Val Phe Ile Ser Glu Glu Ile Gln Met Ser Thr Lys 
            100                 105                 110         


Glu Ser Asp Phe Leu Cys Leu Leu Gly Val Ser Tyr Thr Phe Asp Asn 
        115                 120                 125             


Glu Asp Ser Glu Leu Asn Gly Asp Tyr Gly Glu Asn Ile Tyr Pro Tyr 
    130                 135                 140                 


Glu Glu Asp Lys Asp Glu Lys Ser Ser Ile Tyr Glu Ser Asp Phe Gln 
145                 150                 155                 160 


Ile Glu Pro Gly Phe Tyr Ala Thr Tyr Glu Ser Thr Leu Phe Glu Asp 
                165                 170                 175     


Gln Val Pro Ala Leu Glu Ala Pro Glu Asp Ile Gly Ser Thr Ser Glu 
            180                 185                 190         


Ser Lys Asp Trp Glu Glu Val Val Val Glu Ser Met Glu Gln Asp Arg 
        195                 200                 205             


Ile Pro Glu Val His Val Pro Pro Ser Ser Ala Val Ser Gly Val Lys 
    210                 215                 220                 


Glu Trp Phe Gly Leu Gly Gly Glu Gln Ala Glu Glu Lys Ala Phe Glu 
225                 230                 235                 240 


Ser Val Ile Glu Pro Val Gln Glu Ser Ser Phe Arg Ser Arg Lys Ile 
                245                 250                 255     


Ala Val Glu Asp Glu Asn Asp Leu Glu Glu Leu Asn Asn Gly Glu Pro 
            260                 265                 270         


Gln Thr Glu His Gln Gln Glu Ser Glu Ser Glu Ile Asp Ser Val Pro 
        275                 280                 285             


Lys Thr Gln Ser Glu Leu Ala Ser Glu Ser Glu His Ile Pro Lys Pro 
    290                 295                 300                 


Gln Ser Thr Gly Trp Phe Gly Gly Gly Phe Thr Ser Tyr Leu Gly Phe 
305                 310                 315                 320 


Gly Asp Glu Asp Thr Gly Leu Glu Leu Ile Ala Glu Glu Ser Asn Pro 
                325                 330                 335     


Pro Leu Gln Asp Phe Pro Asn Ser Ile Ser Ser Asp Lys Glu Ala Thr 
            340                 345                 350         


Val Pro Cys Thr Glu Ile Leu Thr Glu Lys Lys Asp Thr Ile Thr Asn 
        355                 360                 365             


Asp Ser Leu Ser Leu Lys Pro Ser Trp Phe Asp Phe Gly Phe Ala Ile 
    370                 375                 380                 


Leu Gly Phe Ala Tyr Ala Lys Glu Asp Lys Ile Met Leu Asp Asp Arg 
385                 390                 395                 400 


Lys Asn Glu Glu Asp Gly Gly Ala Asp Glu His Glu His Pro Leu Thr 
                405                 410                 415     


Ser Glu Leu Asp Pro Glu Lys Glu Gln Glu Ile Glu Thr Ile Lys Ile 
            420                 425                 430         


Ile Glu Thr Glu Asp Gln Ile Asp Lys Lys Pro Val Ser Glu Lys Thr 
        435                 440                 445             


Asp Glu Ser Asp Thr Ile Pro Tyr Leu Lys Lys Phe Leu Tyr Asn Phe 
    450                 455                 460                 


Asp Asn Pro Trp Asn Phe Gln Asn Ile Pro Lys Glu Thr Glu Leu Pro 
465                 470                 475                 480 


Phe Pro Lys Gln Ile Leu Asp Gln Asn Asn Val Ile Glu Asn Glu Glu 
                485                 490                 495     


Thr Gly Glu Phe Ser Ile Asp Asn Tyr Pro Thr Asp Asn Thr Lys Val 
            500                 505                 510         


Met Ile Phe Lys Ser Ser Tyr Ser Leu Ser Asp Met Val Ser Asn Ile 
        515                 520                 525             


Glu Leu Pro Thr Arg Ile His Glu Glu Val Tyr Phe Glu Pro Ser Ser 
    530                 535                 540                 


Ser Lys Asp Ser Asp Glu Asn Ser Lys Pro Ser Val Asp Thr Glu Gly 
545                 550                 555                 560 


Pro Ala Leu Val Glu Ile Asp Arg Ser Val Glu Asn Thr Leu Leu Asn 
                565                 570                 575     


Ser Gln Met Val Ser Thr Asp Asn Ser Leu Ser Ser Gln Asn Tyr Ile 
            580                 585                 590         


Ser Gln Lys Glu Asp Ala Ser Glu Phe Gln Ile Leu Lys Tyr Leu Phe 
        595                 600                 605             


Gln Ile Asp Val Tyr Asp Phe Met Asn Ser Ala Phe Ser Pro Ile Val 
    610                 615                 620                 


Ile Leu Thr Glu Arg Val Val Ala Ala Leu Pro Glu Gly Met Arg Pro 
625                 630                 635                 640 


Asp Ser Asn Leu Tyr Gly Phe Pro Trp Glu Leu Val Ile Cys Ala Ala 
                645                 650                 655     


Val Val Gly Phe Phe Ala Val Leu Phe Phe Leu Trp Arg Ser Phe Arg 
            660                 665                 670         


Ser Val Arg Ser Arg Leu Tyr Val Gly Arg Glu Lys Lys Leu Ala Leu 
        675                 680                 685             


Met Leu Ser Gly Leu Ile Glu Glu Lys Ser Lys Leu Leu Glu Lys Phe 
    690                 695                 700                 


Ser Leu Val Gln Lys Glu Tyr Glu Gly Tyr Glu Val Glu Ser Ser Leu 
705                 710                 715                 720 


Lys Asp Ala Ser Phe Glu Lys Glu Ala Thr Glu Ala Gln Ser Leu Glu 
                725                 730                 735     


Ala Thr Cys Glu Lys Leu Asn Arg Ser Asn Ser Glu Leu Glu Asp Glu 
            740                 745                 750         


Ile Leu Cys Leu Glu Lys Glu Leu Lys Glu Glu Lys Ser Lys His Ser 
        755                 760                 765             


Glu Gln Asp Glu Leu Met Ala Asp Ile Ser Lys Arg Ile Gln Ser Leu 
    770                 775                 780                 


Glu Asp Glu Ser Lys Ser Leu Lys Ser Gln Val Ala Glu Ala Lys Met 
785                 790                 795                 800 


Thr Phe Lys Ile Phe Gln Met Asn Glu Glu Arg Leu Lys Ile Ala Ile 
                805                 810                 815     


Lys Asp Ala Leu Asn Glu Asn Ser Gln Leu Gln Glu Ser Gln Lys Gln 
            820                 825                 830         


Leu Leu Gln Glu Ala Glu Val Trp Lys Glu Gln Val Ser Glu Leu Asn 
        835                 840                 845             


Lys Gln Lys Val Thr Phe Glu Asp Ser Lys Val His Ala Glu Gln Val 
    850                 855                 860                 


Leu Asn Asp Lys Glu Ser His Ile Lys Thr Leu Thr Glu Arg Leu Leu 
865                 870                 875                 880 


Lys Met Lys Asp Trp Ala Ala Met Leu Gly Glu Asp Ile Thr Asp Asp 
                885                 890                 895     


Asp Asn Leu Glu Leu Glu Met Asn Ser Glu Ser Glu Asn Gly Ala Tyr 
            900                 905                 910         


Leu Asp Asn Pro Pro Lys Gly Ala Leu Lys Lys Leu Ile His Ala Ala 
        915                 920                 925             


Lys Leu Asn Ala Ser Leu Lys Thr Leu Glu Gly Glu Arg Asn Gln Ile 
    930                 935                 940                 


Tyr Ile Gln Leu Ser Glu Val Asp Lys Thr Lys Glu Glu Leu Thr Glu 
945                 950                 955                 960 


His Ile Lys Asn Leu Gln Thr Glu Gln Ala Ser Leu Gln Ser Glu Asn 
                965                 970                 975     


Thr His Phe Glu Asn Glu Asn Gln Lys Leu Gln Gln Lys Leu Lys Val 
            980                 985                 990         


Met Thr Glu Leu Tyr Gln Glu Asn  Glu Met Lys Leu His  Arg Lys Leu 
        995                 1000                 1005             


Thr Val  Glu Glu Asn Tyr Arg  Leu Glu Lys Glu Glu  Lys Leu Ser 
    1010                 1015                 1020             


Lys Val  Asp Glu Lys Ile Ser  His Ala Thr Glu Glu  Leu Glu Thr 
    1025                 1030                 1035             


Tyr Arg  Lys Arg Ala Lys Asp  Leu Glu Glu Glu Leu  Glu Arg Thr 
    1040                 1045                 1050             


Ile His  Ser Tyr Gln Gly Gln  Ile Ile Ser His Glu  Lys Lys Ala 
    1055                 1060                 1065             


His Asp  Asn Trp Leu Ala Ala  Arg Asn Ala Glu Arg  Asn Leu Asn 
    1070                 1075                 1080             


Asp Leu  Arg Lys Glu Asn Ala  His Asn Arg Gln Lys  Leu Thr Glu 
    1085                 1090                 1095             


Thr Glu  Leu Lys Phe Glu Leu  Leu Glu Lys Asp Pro  Tyr Ala Leu 
    1100                 1105                 1110             


Asp Val  Pro Asn Thr Ala Phe  Gly Arg Glu His Ser  Pro Tyr Gly 
    1115                 1120                 1125             


Pro Ser  Pro Leu Gly Trp Pro  Ser Ser Glu Thr Arg  Ala Phe Leu 
    1130                 1135                 1140             


Ser Pro  Pro Thr Leu Leu Glu  Gly Pro Leu Arg Leu  Ser Pro Leu 
    1145                 1150                 1155             


Leu Pro  Gly Gly Gly Gly Arg  Gly Ser Arg Gly Pro  Gly Asn Pro 
    1160                 1165                 1170             


Leu Asp  His Gln Ile Thr Asn  Glu Arg Gly Glu Ser  Ser Cys Asp 
    1175                 1180                 1185             


Arg Leu  Thr Asp Pro His Arg  Ala Pro Ser Asp Thr  Gly Ser Leu 
    1190                 1195                 1200             


Ser Pro  Pro Trp Asp Gln Asp  Arg Arg Met Met Phe  Pro Pro Pro 
    1205                 1210                 1215             


Gly Gln  Ser Tyr Pro Asp Ser  Ala Leu Pro Pro Gln  Arg Gln Asp 
    1220                 1225                 1230             


Arg Phe  Cys Ser Asn Ser Gly  Arg Leu Ser Gly Pro  Ala Glu Leu 
    1235                 1240                 1245             


Arg Ser  Phe Asn Met Pro Ser  Leu Asp Lys Met Asp  Gly Ser Met 
    1250                 1255                 1260             


Pro Ser  Glu Met Glu Ser Ser  Arg Asn Asp Thr Lys  Asp Asp Leu 
    1265                 1270                 1275             


Gly Asn  Leu Asn Val Pro Asp  Ser Ser Leu Pro Ala  Glu Asn Glu 
    1280                 1285                 1290             


Ala Thr  Gly Pro Gly Phe Val  Pro Pro Pro Leu Ala  Pro Ile Arg 
    1295                 1300                 1305             


Gly Pro  Leu Phe Pro Val Asp  Ala Arg Gly Pro Phe  Leu Arg Arg 
    1310                 1315                 1320             


Gly Pro  Pro Phe Pro Pro Pro  Pro Pro Gly Ala Met  Phe Gly Ala 
    1325                 1330                 1335             


Ser Arg  Asp Tyr Phe Pro Pro  Gly Asp Phe Pro Gly  Pro Pro Pro 
    1340                 1345                 1350             


Ala Pro  Phe Ala Met Arg Asn  Val Tyr Pro Pro Arg  Gly Phe Pro 
    1355                 1360                 1365             


Pro Tyr  Leu Pro Pro Arg Pro  Gly Phe Phe Pro Pro  Pro Pro His 
    1370                 1375                 1380             


Ser Glu  Gly Arg Ser Glu Phe  Pro Ser Gly Leu Ile  Pro Pro Ser 
    1385                 1390                 1395             


Asn Glu  Pro Ala Thr Glu His  Pro Glu Pro Gln Gln  Glu Thr 
    1400                 1405                 1410         


<210>  8710
<211>  1907
<212>  PRT
<213>  Homo Sapiens

<400>  8710

Met Ala Ala Ala Pro Gly Leu Leu Val Trp Leu Leu Val Leu Arg Leu 
1               5                   10                  15      


Pro Trp Arg Val Pro Gly Gln Leu Asp Pro Ser Thr Gly Arg Arg Phe 
            20                  25                  30          


Ser Glu His Lys Leu Cys Ala Asp Asp Glu Cys Ser Met Leu Met Tyr 
        35                  40                  45              


Arg Gly Glu Ala Leu Glu Asp Phe Thr Gly Pro Asp Cys Arg Phe Val 
    50                  55                  60                  


Asn Phe Lys Lys Gly Asp Pro Val Tyr Val Tyr Tyr Lys Leu Ala Arg 
65                  70                  75                  80  


Gly Trp Pro Glu Val Trp Ala Gly Ser Val Gly Arg Thr Phe Gly Tyr 
                85                  90                  95      


Phe Pro Lys Asp Leu Ile Gln Val Val His Glu Tyr Thr Lys Glu Glu 
            100                 105                 110         


Leu Gln Val Pro Thr Asp Glu Thr Asp Phe Val Cys Phe Asp Gly Gly 
        115                 120                 125             


Arg Asp Asp Phe His Asn Tyr Asn Val Glu Glu Leu Leu Gly Phe Leu 
    130                 135                 140                 


Glu Leu Tyr Asn Ser Ala Ala Thr Asp Ser Glu Lys Ala Val Glu Lys 
145                 150                 155                 160 


Thr Leu Gln Asp Met Glu Lys Asn Pro Glu Leu Ser Lys Glu Arg Glu 
                165                 170                 175     


Pro Glu Pro Glu Pro Val Glu Ala Asn Ser Glu Glu Ser Asp Ser Val 
            180                 185                 190         


Phe Ser Glu Asn Thr Glu Asp Leu Gln Glu Gln Phe Thr Thr Gln Lys 
        195                 200                 205             


His His Ser His Ala Asn Ser Gln Ala Asn His Ala Gln Gly Glu Gln 
    210                 215                 220                 


Ala Ser Phe Glu Ser Phe Glu Glu Met Leu Gln Asp Lys Leu Lys Val 
225                 230                 235                 240 


Pro Glu Ser Glu Asn Asn Lys Thr Ser Asn Ser Ser Gln Val Ser Asn 
                245                 250                 255     


Glu Gln Asp Lys Ile Asp Ala Tyr Lys Leu Leu Lys Lys Glu Met Thr 
            260                 265                 270         


Leu Asp Leu Lys Thr Lys Phe Gly Ser Thr Ala Asp Ala Leu Val Ser 
        275                 280                 285             


Asp Asp Glu Thr Thr Arg Leu Val Thr Ser Leu Glu Asp Asp Phe Asp 
    290                 295                 300                 


Glu Glu Leu Asp Thr Glu Tyr Tyr Ala Val Gly Lys Glu Asp Glu Glu 
305                 310                 315                 320 


Asn Gln Glu Asp Phe Asp Glu Leu Pro Leu Leu Thr Phe Thr Asp Gly 
                325                 330                 335     


Glu Asp Met Lys Thr Pro Ala Lys Ser Gly Val Glu Lys Tyr Pro Thr 
            340                 345                 350         


Asp Lys Glu Gln Asn Ser Asn Glu Glu Asp Lys Val Gln Leu Thr Val 
        355                 360                 365             


Pro Pro Gly Ile Lys Asn Asp Asp Lys Asn Ile Leu Thr Thr Trp Gly 
    370                 375                 380                 


Asp Thr Ile Phe Ser Ile Val Thr Gly Gly Glu Glu Thr Arg Asp Thr 
385                 390                 395                 400 


Met Asp Leu Glu Ser Ser Ser Ser Glu Glu Glu Lys Glu Asp Asp Asp 
                405                 410                 415     


Asp Ala Leu Val Pro Asp Ser Lys Gln Gly Lys Pro Gln Ser Ala Thr 
            420                 425                 430         


Asp Tyr Ser Asp Pro Asp Asn Val Asp Asp Gly Leu Phe Ile Val Asp 
        435                 440                 445             


Ile Pro Lys Thr Asn Asn Asp Lys Glu Val Asn Ala Glu His His Ile 
    450                 455                 460                 


Lys Gly Lys Gly Arg Gly Val Gln Glu Ser Lys Arg Gly Leu Val Gln 
465                 470                 475                 480 


Asp Lys Thr Glu Leu Glu Asp Glu Asn Gln Glu Gly Met Thr Val His 
                485                 490                 495     


Ser Ser Val His Ser Asn Asn Leu Asn Ser Met Pro Ala Ala Glu Lys 
            500                 505                 510         


Gly Lys Asp Thr Leu Lys Ser Ala Tyr Asp Asp Thr Glu Asn Asp Leu 
        515                 520                 525             


Lys Gly Ala Ala Ile His Ile Ser Lys Gly Met Leu His Glu Glu Lys 
    530                 535                 540                 


Pro Gly Glu Gln Ile Leu Glu Gly Gly Ser Glu Ser Glu Ser Ala Gln 
545                 550                 555                 560 


Lys Ala Ala Gly Asn Gln Met Asn Asp Arg Lys Ile Gln Gln Glu Ser 
                565                 570                 575     


Leu Gly Ser Ala Pro Leu Met Gly Asp Asp His Pro Asn Ala Ser Arg 
            580                 585                 590         


Asp Ser Val Glu Gly Asp Ala Leu Val Asn Gly Ala Lys Leu His Thr 
        595                 600                 605             


Leu Ser Val Glu His Gln Arg Glu Glu Leu Lys Glu Glu Leu Val Leu 
    610                 615                 620                 


Lys Thr Gln Asn Gln Pro Arg Phe Ser Ser Pro Asp Glu Ile Asp Leu 
625                 630                 635                 640 


Pro Arg Glu Leu Glu Asp Glu Val Pro Ile Leu Gly Arg Asn Leu Pro 
                645                 650                 655     


Trp Gln Gln Glu Arg Asp Val Ala Ala Thr Ala Ser Lys Gln Met Ser 
            660                 665                 670         


Glu Lys Ile Arg Leu Ser Glu Gly Glu Ala Lys Glu Asp Ser Leu Asp 
        675                 680                 685             


Glu Glu Phe Phe His His Lys Ala Met Gln Gly Thr Glu Val Gly Gln 
    690                 695                 700                 


Thr Asp Gln Thr Asp Ser Thr Gly Gly Pro Ala Phe Leu Ser Lys Val 
705                 710                 715                 720 


Glu Glu Asp Asp Tyr Pro Ser Glu Glu Leu Leu Glu Asp Glu Asn Ala 
                725                 730                 735     


Ile Asn Ala Lys Arg Ser Lys Glu Lys Asn Pro Gly Asn Gln Gly Arg 
            740                 745                 750         


Gln Phe Asp Val Asn Leu Gln Val Pro Asp Arg Ala Val Leu Gly Thr 
        755                 760                 765             


Ile His Pro Asp Pro Glu Ile Glu Glu Ser Lys Gln Glu Thr Ser Met 
    770                 775                 780                 


Ile Leu Asp Ser Glu Lys Thr Ser Glu Thr Ala Ala Lys Gly Val Asn 
785                 790                 795                 800 


Thr Gly Gly Arg Glu Pro Asn Thr Met Val Glu Lys Glu Arg Pro Leu 
                805                 810                 815     


Ala Asp Lys Lys Ala Gln Arg Pro Phe Glu Arg Ser Asp Phe Ser Asp 
            820                 825                 830         


Ser Ile Lys Ile Gln Thr Pro Glu Leu Gly Glu Val Phe Gln Asn Lys 
        835                 840                 845             


Asp Ser Asp Tyr Leu Lys Asn Asp Asn Pro Glu Glu His Leu Lys Thr 
    850                 855                 860                 


Ser Gly Leu Ala Gly Glu Pro Glu Gly Glu Leu Ser Lys Glu Asp His 
865                 870                 875                 880 


Glu Asn Thr Glu Lys Tyr Met Gly Thr Glu Ser Gln Gly Ser Ala Ala 
                885                 890                 895     


Ala Glu Pro Glu Asp Asp Ser Phe His Trp Thr Pro His Thr Ser Val 
            900                 905                 910         


Glu Pro Gly His Ser Asp Lys Arg Glu Asp Leu Leu Ile Ile Ser Ser 
        915                 920                 925             


Phe Phe Lys Glu Gln Gln Ser Leu Gln Arg Phe Gln Lys Tyr Phe Asn 
    930                 935                 940                 


Val His Glu Leu Glu Ala Leu Leu Gln Glu Met Ser Ser Lys Leu Lys 
945                 950                 955                 960 


Ser Ala Gln Gln Glu Ser Leu Pro Tyr Asn Met Glu Lys Val Leu Asp 
                965                 970                 975     


Lys Val Phe Arg Ala Ser Glu Ser Gln Ile Leu Ser Ile Ala Glu Lys 
            980                 985                 990         


Met Leu Asp Thr Arg Val Ala Glu  Asn Arg Asp Leu Gly  Met Asn Glu 
        995                 1000                 1005             


Asn Asn  Ile Phe Glu Glu Ala  Ala Val Leu Asp Asp  Ile Gln Asp 
    1010                 1015                 1020             


Leu Ile  Tyr Phe Val Arg Tyr  Lys His Ser Thr Ala  Glu Glu Thr 
    1025                 1030                 1035             


Ala Thr  Leu Val Met Ala Pro  Pro Leu Glu Glu Gly  Leu Gly Gly 
    1040                 1045                 1050             


Ala Met  Glu Glu Met Gln Pro  Leu His Glu Asp Asn  Phe Ser Arg 
    1055                 1060                 1065             


Glu Lys  Thr Ala Glu Leu Asn  Val Gln Val Pro Glu  Glu Pro Thr 
    1070                 1075                 1080             


His Leu  Asp Gln Arg Val Ile  Gly Asp Thr His Ala  Ser Glu Val 
    1085                 1090                 1095             


Ser Gln  Lys Pro Asn Thr Glu  Lys Asp Leu Asp Pro  Gly Pro Val 
    1100                 1105                 1110             


Thr Thr  Glu Asp Thr Pro Met  Asp Ala Ile Asp Ala  Asn Lys Gln 
    1115                 1120                 1125             


Pro Glu  Thr Ala Ala Glu Glu  Pro Ala Ser Val Thr  Pro Leu Glu 
    1130                 1135                 1140             


Asn Ala  Ile Leu Leu Ile Tyr  Ser Phe Met Phe Tyr  Leu Thr Lys 
    1145                 1150                 1155             


Ser Leu  Val Ala Thr Leu Pro  Asp Asp Val Gln Pro  Gly Pro Asp 
    1160                 1165                 1170             


Phe Tyr  Gly Leu Pro Trp Lys  Pro Val Phe Ile Thr  Ala Phe Leu 
    1175                 1180                 1185             


Gly Ile  Ala Ser Phe Ala Ile  Phe Leu Trp Arg Thr  Val Leu Val 
    1190                 1195                 1200             


Val Lys  Asp Arg Val Tyr Gln  Val Thr Glu Gln Gln  Ile Ser Glu 
    1205                 1210                 1215             


Lys Leu  Lys Thr Ile Met Lys  Glu Asn Thr Glu Leu  Val Gln Lys 
    1220                 1225                 1230             


Leu Ser  Asn Tyr Glu Gln Lys  Ile Lys Glu Ser Lys  Lys His Val 
    1235                 1240                 1245             


Gln Glu  Thr Arg Lys Gln Asn  Met Ile Leu Ser Asp  Glu Ala Ile 
    1250                 1255                 1260             


Lys Tyr  Lys Asp Lys Ile Lys  Thr Leu Glu Lys Asn  Gln Glu Ile 
    1265                 1270                 1275             


Leu Asp  Asp Thr Ala Lys Asn  Leu Arg Val Met Leu  Glu Ser Glu 
    1280                 1285                 1290             


Arg Glu  Gln Asn Val Lys Asn  Gln Asp Leu Ile Ser  Glu Asn Lys 
    1295                 1300                 1305             


Lys Ser  Ile Glu Lys Leu Lys  Asp Val Ile Ser Met  Asn Ala Ser 
    1310                 1315                 1320             


Glu Phe  Ser Glu Val Gln Ile  Ala Leu Asn Glu Ala  Lys Leu Ser 
    1325                 1330                 1335             


Glu Glu  Lys Val Lys Ser Glu  Cys His Arg Val Gln  Glu Glu Asn 
    1340                 1345                 1350             


Ala Arg  Leu Lys Lys Lys Lys  Glu Gln Leu Gln Gln  Glu Ile Glu 
    1355                 1360                 1365             


Asp Trp  Ser Lys Leu His Ala  Glu Leu Ser Glu Gln  Ile Lys Ser 
    1370                 1375                 1380             


Phe Glu  Lys Ser Gln Lys Asp  Leu Glu Val Ala Leu  Thr His Lys 
    1385                 1390                 1395             


Asp Asp  Asn Ile Asn Ala Leu  Thr Asn Cys Ile Thr  Gln Leu Asn 
    1400                 1405                 1410             


Leu Leu  Glu Cys Glu Ser Glu  Ser Glu Gly Gln Asn  Lys Gly Gly 
    1415                 1420                 1425             


Asn Asp  Ser Asp Glu Leu Ala  Asn Gly Glu Val Gly  Gly Asp Arg 
    1430                 1435                 1440             


Asn Glu  Lys Met Lys Asn Gln  Ile Lys Gln Met Met  Asp Val Ser 
    1445                 1450                 1455             


Arg Thr  Gln Thr Ala Ile Ser  Val Val Glu Glu Asp  Leu Lys Leu 
    1460                 1465                 1470             


Leu Gln  Leu Lys Leu Arg Ala  Ser Val Ser Thr Lys  Cys Asn Leu 
    1475                 1480                 1485             


Glu Asp  Gln Val Lys Lys Leu  Glu Asp Asp Arg Asn  Ser Leu Gln 
    1490                 1495                 1500             


Ala Ala  Lys Ala Gly Leu Glu  Asp Glu Cys Lys Thr  Leu Arg Gln 
    1505                 1510                 1515             


Lys Val  Glu Ile Leu Asn Glu  Leu Tyr Gln Gln Lys  Glu Met Ala 
    1520                 1525                 1530             


Leu Gln  Lys Lys Leu Ser Gln  Glu Glu Tyr Glu Arg  Gln Glu Arg 
    1535                 1540                 1545             


Glu His  Arg Leu Ser Ala Ala  Asp Glu Lys Ala Val  Ser Ala Ala 
    1550                 1555                 1560             


Glu Glu  Val Lys Thr Tyr Lys  Arg Arg Ile Glu Glu  Met Glu Asp 
    1565                 1570                 1575             


Glu Leu  Gln Lys Thr Glu Arg  Ser Phe Lys Asn Gln  Ile Ala Thr 
    1580                 1585                 1590             


His Glu  Lys Lys Ala His Glu  Asn Trp Leu Lys Ala  Arg Ala Ala 
    1595                 1600                 1605             


Glu Arg  Ala Ile Ala Glu Glu  Lys Arg Glu Ala Ala  Asn Leu Arg 
    1610                 1615                 1620             


His Lys  Leu Leu Glu Leu Thr  Gln Lys Met Ala Met  Leu Gln Glu 
    1625                 1630                 1635             


Glu Pro  Val Ile Val Lys Pro  Met Pro Gly Lys Pro  Asn Thr Gln 
    1640                 1645                 1650             


Asn Pro  Pro Arg Arg Gly Pro  Leu Ser Gln Asn Gly  Ser Phe Gly 
    1655                 1660                 1665             


Pro Ser  Pro Val Ser Gly Gly  Glu Cys Ser Pro Pro  Leu Thr Val 
    1670                 1675                 1680             


Glu Pro  Pro Val Arg Pro Leu  Ser Ala Thr Leu Asn  Arg Arg Asp 
    1685                 1690                 1695             


Met Pro  Arg Ser Glu Phe Gly  Ser Val Asp Gly Pro  Leu Pro His 
    1700                 1705                 1710             


Pro Arg  Trp Ser Ala Glu Ala  Ser Gly Lys Pro Ser  Pro Ser Asp 
    1715                 1720                 1725             


Pro Gly  Ser Gly Thr Ala Thr  Met Met Asn Ser Ser  Ser Arg Gly 
    1730                 1735                 1740             


Ser Ser  Pro Thr Arg Val Leu  Asp Glu Gly Lys Val  Asn Met Ala 
    1745                 1750                 1755             


Pro Lys  Gly Pro Pro Pro Phe  Pro Gly Val Pro Leu  Met Ser Thr 
    1760                 1765                 1770             


Pro Met  Gly Gly Pro Val Pro  Pro Pro Ile Arg Tyr  Gly Pro Pro 
    1775                 1780                 1785             


Pro Gln  Leu Cys Gly Pro Phe  Gly Pro Arg Pro Leu  Pro Pro Pro 
    1790                 1795                 1800             


Phe Gly  Pro Gly Met Arg Pro  Pro Leu Gly Leu Arg  Glu Phe Ala 
    1805                 1810                 1815             


Pro Gly  Val Pro Pro Gly Arg  Arg Asp Leu Pro Leu  His Pro Arg 
    1820                 1825                 1830             


Gly Phe  Leu Pro Gly His Ala  Pro Phe Arg Pro Leu  Gly Ser Leu 
    1835                 1840                 1845             


Gly Pro  Arg Glu Tyr Phe Ile  Pro Gly Thr Arg Leu  Pro Pro Pro 
    1850                 1855                 1860             


Thr His  Gly Pro Gln Glu Tyr  Pro Pro Pro Pro Ala  Val Arg Asp 
    1865                 1870                 1875             


Leu Leu  Pro Ser Gly Ser Arg  Asp Glu Pro Pro Pro  Ala Ser Gln 
    1880                 1885                 1890             


Ser Thr  Ser Gln Asp Cys Ser  Gln Ala Leu Lys Gln  Ser Pro 
    1895                 1900                 1905         


<210>  8711
<211>  500
<212>  PRT
<213>  Homo Sapiens

<400>  8711

Met Ala Ala Ala Pro Gly Leu Leu Val Trp Leu Leu Val Leu Arg Leu 
1               5                   10                  15      


Pro Trp Arg Val Pro Gly Gln Leu Asp Pro Ser Thr Gly Arg Arg Phe 
            20                  25                  30          


Ser Glu His Lys Leu Cys Ala Asp Asp Glu Cys Ser Met Leu Met Tyr 
        35                  40                  45              


Arg Gly Glu Ala Leu Glu Asp Phe Thr Gly Pro Asp Cys Arg Phe Val 
    50                  55                  60                  


Asn Phe Lys Lys Gly Asp Pro Val Tyr Val Tyr Tyr Lys Leu Ala Arg 
65                  70                  75                  80  


Gly Trp Pro Glu Val Trp Ala Gly Ser Val Gly Arg Thr Phe Gly Tyr 
                85                  90                  95      


Phe Pro Lys Asp Leu Ile Gln Val Val His Glu Tyr Thr Lys Glu Glu 
            100                 105                 110         


Leu Gln Val Pro Thr Asp Glu Thr Asp Phe Val Cys Phe Asp Gly Gly 
        115                 120                 125             


Arg Asp Asp Phe His Asn Tyr Asn Val Glu Glu Leu Leu Gly Phe Leu 
    130                 135                 140                 


Glu Leu Tyr Asn Ser Ala Ala Thr Asp Ser Glu Lys Ala Val Glu Lys 
145                 150                 155                 160 


Thr Leu Gln Asp Met Glu Lys Asn Pro Glu Leu Ser Lys Glu Arg Glu 
                165                 170                 175     


Pro Glu Pro Glu Pro Val Glu Ala Asn Ser Glu Glu Ser Asp Ser Val 
            180                 185                 190         


Phe Ser Glu Asn Thr Glu Asp Leu Gln Glu Gln Phe Thr Thr Gln Lys 
        195                 200                 205             


His His Ser His Ala Asn Ser Gln Ala Asn His Ala Gln Gly Glu Gln 
    210                 215                 220                 


Ala Ser Phe Glu Ser Phe Glu Glu Met Leu Gln Asp Lys Leu Lys Val 
225                 230                 235                 240 


Pro Glu Ser Glu Asn Asn Lys Thr Ser Asn Ser Ser Gln Val Ser Asn 
                245                 250                 255     


Glu Gln Asp Lys Ile Asp Ala Tyr Lys Leu Leu Lys Lys Glu Met Thr 
            260                 265                 270         


Leu Asp Leu Lys Thr Lys Phe Gly Ser Thr Ala Asp Ala Leu Val Ser 
        275                 280                 285             


Asp Asp Glu Thr Thr Arg Leu Val Thr Ser Leu Glu Asp Asp Phe Asp 
    290                 295                 300                 


Glu Glu Leu Asp Thr Glu Tyr Tyr Ala Val Gly Lys Glu Asp Glu Glu 
305                 310                 315                 320 


Asn Gln Glu Asp Phe Asp Glu Leu Pro Leu Leu Thr Phe Thr Asp Gly 
                325                 330                 335     


Glu Asp Met Lys Thr Pro Ala Lys Ser Gly Val Glu Lys Tyr Pro Thr 
            340                 345                 350         


Asp Lys Glu Gln Asn Ser Asn Glu Glu Asp Lys Val Gln Leu Thr Val 
        355                 360                 365             


Pro Pro Gly Ile Lys Asn Asp Asp Lys Asn Ile Leu Thr Thr Trp Gly 
    370                 375                 380                 


Asp Thr Ile Phe Ser Ile Val Thr Gly Gly Glu Glu Thr Arg Asp Thr 
385                 390                 395                 400 


Met Asp Leu Glu Ser Ser Ser Ser Glu Glu Glu Lys Glu Asp Asp Asp 
                405                 410                 415     


Asp Ala Leu Val Pro Asp Ser Lys Gln Gly Lys Pro Gln Ser Ala Thr 
            420                 425                 430         


Asp Tyr Ser Asp Pro Asp Asn Val Asp Asp Gly Leu Phe Ile Val Asp 
        435                 440                 445             


Ile Pro Lys Thr Asn Asn Asp Lys Glu Val Asn Ala Glu His His Ile 
    450                 455                 460                 


Lys Gly Lys Gly Arg Gly Val Gln Glu Ser Lys Arg Gly Leu Val Gln 
465                 470                 475                 480 


Asp Lys Thr Glu Leu Glu Asp Glu Asn Gln Glu Gly Phe Lys Thr Glu 
                485                 490                 495     


Pro Ile Lys Leu 
            500 


<210>  8712
<211>  785
<212>  PRT
<213>  Homo Sapiens

<400>  8712

Met Asp Ser Val Pro Ala Thr Val Pro Ser Ile Ala Ala Thr Pro Gly 
1               5                   10                  15      


Asp Pro Glu Leu Val Gly Pro Leu Ser Val Leu Tyr Ala Ala Phe Ile 
            20                  25                  30          


Ala Lys Leu Leu Glu Leu Val Ala Thr Leu Pro Asp Asp Val Gln Pro 
        35                  40                  45              


Gly Pro Asp Phe Tyr Gly Leu Pro Trp Lys Pro Val Phe Ile Thr Ala 
    50                  55                  60                  


Phe Leu Gly Ile Ala Ser Phe Ala Ile Phe Leu Trp Arg Thr Val Leu 
65                  70                  75                  80  


Val Val Lys Asp Arg Val Tyr Gln Val Thr Glu Gln Gln Ile Ser Glu 
                85                  90                  95      


Lys Leu Lys Thr Ile Met Lys Glu Asn Thr Glu Leu Val Gln Lys Leu 
            100                 105                 110         


Ser Asn Tyr Glu Gln Lys Ile Lys Glu Ser Lys Lys His Val Gln Glu 
        115                 120                 125             


Thr Arg Lys Gln Asn Met Ile Leu Ser Asp Glu Ala Ile Lys Tyr Lys 
    130                 135                 140                 


Asp Lys Ile Lys Thr Leu Glu Lys Asn Gln Glu Ile Leu Asp Asp Thr 
145                 150                 155                 160 


Ala Lys Asn Leu Arg Val Met Leu Glu Ser Glu Arg Glu Gln Asn Val 
                165                 170                 175     


Lys Asn Gln Asp Leu Ile Ser Glu Asn Lys Lys Ser Ile Glu Lys Leu 
            180                 185                 190         


Lys Asp Val Ile Ser Met Asn Ala Ser Glu Phe Ser Glu Val Gln Ile 
        195                 200                 205             


Ala Leu Asn Glu Ala Lys Leu Ser Glu Glu Lys Val Lys Ser Glu Cys 
    210                 215                 220                 


His Arg Val Gln Glu Glu Asn Ala Arg Leu Lys Lys Lys Lys Glu Gln 
225                 230                 235                 240 


Leu Gln Gln Glu Ile Glu Asp Trp Ser Lys Leu His Ala Glu Leu Ser 
                245                 250                 255     


Glu Gln Ile Lys Ser Phe Glu Lys Ser Gln Lys Asp Leu Glu Val Ala 
            260                 265                 270         


Leu Thr His Lys Asp Asp Asn Ile Asn Ala Leu Thr Asn Cys Ile Thr 
        275                 280                 285             


Gln Leu Asn Leu Leu Glu Cys Glu Ser Glu Ser Glu Gly Gln Asn Lys 
    290                 295                 300                 


Gly Gly Asn Asp Ser Asp Glu Leu Ala Asn Gly Glu Val Gly Gly Asp 
305                 310                 315                 320 


Arg Asn Glu Lys Met Lys Asn Gln Ile Lys Gln Met Met Asp Val Ser 
                325                 330                 335     


Arg Thr Gln Thr Ala Ile Ser Val Val Glu Glu Asp Leu Lys Leu Leu 
            340                 345                 350         


Gln Leu Lys Leu Arg Ala Ser Val Ser Thr Lys Cys Asn Leu Glu Asp 
        355                 360                 365             


Gln Val Lys Lys Leu Glu Asp Asp Arg Asn Ser Leu Gln Ala Ala Lys 
    370                 375                 380                 


Ala Gly Leu Glu Asp Glu Cys Lys Thr Leu Arg Gln Lys Val Glu Ile 
385                 390                 395                 400 


Leu Asn Glu Leu Tyr Gln Gln Lys Glu Met Ala Leu Gln Lys Lys Leu 
                405                 410                 415     


Ser Gln Glu Glu Tyr Glu Arg Gln Glu Arg Glu His Arg Leu Ser Ala 
            420                 425                 430         


Ala Asp Glu Lys Ala Val Ser Ala Ala Glu Glu Val Lys Thr Tyr Lys 
        435                 440                 445             


Arg Arg Ile Glu Glu Met Glu Asp Glu Leu Gln Lys Thr Glu Arg Ser 
    450                 455                 460                 


Phe Lys Asn Gln Ile Ala Thr His Glu Lys Lys Ala His Glu Asn Trp 
465                 470                 475                 480 


Leu Lys Ala Arg Ala Ala Glu Arg Ala Ile Ala Glu Glu Lys Arg Glu 
                485                 490                 495     


Ala Ala Asn Leu Arg His Lys Leu Leu Glu Leu Thr Gln Lys Met Ala 
            500                 505                 510         


Met Leu Gln Glu Glu Pro Val Ile Val Lys Pro Met Pro Gly Lys Pro 
        515                 520                 525             


Asn Thr Gln Asn Pro Pro Arg Arg Gly Pro Leu Ser Gln Asn Gly Ser 
    530                 535                 540                 


Phe Gly Pro Ser Pro Val Ser Gly Gly Glu Cys Ser Pro Pro Leu Thr 
545                 550                 555                 560 


Val Glu Pro Pro Val Arg Pro Leu Ser Ala Thr Leu Asn Arg Arg Asp 
                565                 570                 575     


Met Pro Arg Ser Glu Phe Gly Ser Val Asp Gly Pro Leu Pro His Pro 
            580                 585                 590         


Arg Trp Ser Ala Glu Ala Ser Gly Lys Pro Ser Pro Ser Asp Pro Gly 
        595                 600                 605             


Ser Gly Thr Ala Thr Met Met Asn Ser Ser Ser Arg Gly Ser Ser Pro 
    610                 615                 620                 


Thr Arg Val Leu Asp Glu Gly Lys Val Asn Met Ala Pro Lys Gly Pro 
625                 630                 635                 640 


Pro Pro Phe Pro Gly Val Pro Leu Met Ser Thr Pro Met Gly Gly Pro 
                645                 650                 655     


Val Pro Pro Pro Ile Arg Tyr Gly Pro Pro Pro Gln Leu Cys Gly Pro 
            660                 665                 670         


Phe Gly Pro Arg Pro Leu Pro Pro Pro Phe Gly Pro Gly Met Arg Pro 
        675                 680                 685             


Pro Leu Gly Leu Arg Glu Phe Ala Pro Gly Val Pro Pro Gly Arg Arg 
    690                 695                 700                 


Asp Leu Pro Leu His Pro Arg Gly Phe Leu Pro Gly His Ala Pro Phe 
705                 710                 715                 720 


Arg Pro Leu Gly Ser Leu Gly Pro Arg Glu Tyr Phe Ile Pro Gly Thr 
                725                 730                 735     


Arg Leu Pro Pro Pro Thr His Gly Pro Gln Glu Tyr Pro Pro Pro Pro 
            740                 745                 750         


Ala Val Arg Asp Leu Leu Pro Ser Gly Ser Arg Asp Glu Pro Pro Pro 
        755                 760                 765             


Ala Ser Gln Ser Thr Ser Gln Asp Cys Ser Gln Ala Leu Lys Gln Ser 
    770                 775                 780                 


Pro 
785 


<210>  8713
<211>  1016
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8713

Xaa Leu Val Pro Asp Ser Lys Gln Gly Lys Pro Gln Ser Ala Thr Asp 
1               5                   10                  15      


Tyr Ser Asp Pro Asp Asn Val Asp Asp Gly Leu Phe Ile Val Asp Ile 
            20                  25                  30          


Pro Lys Thr Asn Asn Asp Lys Glu Val Asn Ala Glu His His Ile Lys 
        35                  40                  45              


Gly Lys Gly Arg Gly Val Gln Glu Ser Lys Arg Gly Leu Val Gln Asp 
    50                  55                  60                  


Lys Thr Glu Leu Glu Asp Glu Asn Gln Glu Gly Met Thr Val His Ser 
65                  70                  75                  80  


Ser Val His Ser Asn Asn Leu Asn Ser Met Pro Ala Ala Glu Lys Gly 
                85                  90                  95      


Lys Asp Thr Leu Lys Ser Ala Tyr Asp Asp Thr Glu Asn Asp Leu Lys 
            100                 105                 110         


Gly Ala Ala Ile His Ile Ser Lys Gly Met Leu His Glu Glu Lys Pro 
        115                 120                 125             


Gly Glu Gln Ile Leu Glu Gly Gly Ser Glu Ser Glu Ser Ala Gln Lys 
    130                 135                 140                 


Ala Ala Gly Asn Gln Met Asn Asp Arg Lys Ile Gln Gln Glu Ser Leu 
145                 150                 155                 160 


Gly Ser Ala Pro Leu Met Gly Asp Asp His Pro Asn Ala Ser Arg Asp 
                165                 170                 175     


Ser Val Glu Gly Asp Ala Leu Val Asn Gly Ala Lys Leu His Thr Leu 
            180                 185                 190         


Ser Val Glu His Gln Arg Glu Glu Leu Lys Glu Glu Leu Val Leu Lys 
        195                 200                 205             


Thr Gln Asn Gln Pro Arg Phe Ser Ser Pro Asp Glu Ile Asp Leu Pro 
    210                 215                 220                 


Arg Glu Leu Glu Asp Glu Val Pro Ile Leu Gly Arg Asn Leu Pro Trp 
225                 230                 235                 240 


Gln Gln Glu Arg Asp Val Ala Ala Thr Ala Ser Lys Gln Met Ser Glu 
                245                 250                 255     


Lys Ile Arg Leu Ser Glu Gly Glu Ala Lys Glu Asp Ser Leu Asp Glu 
            260                 265                 270         


Glu Phe Phe His His Lys Ala Met Gln Gly Thr Glu Val Gly Gln Thr 
        275                 280                 285             


Asp Gln Thr Asp Ser Thr Gly Gly Pro Ala Phe Leu Ser Lys Val Glu 
    290                 295                 300                 


Glu Asp Asp Tyr Pro Ser Glu Glu Leu Leu Glu Asp Glu Asn Ala Ile 
305                 310                 315                 320 


Asn Ala Lys Arg Ser Lys Glu Lys Asn Pro Gly Asn Gln Gly Arg Gln 
                325                 330                 335     


Phe Asp Val Asn Leu Gln Val Pro Asp Arg Ala Val Leu Gly Thr Ile 
            340                 345                 350         


His Pro Asp Pro Glu Ile Glu Glu Ser Lys Gln Glu Thr Ser Met Ile 
        355                 360                 365             


Leu Asp Ser Glu Lys Thr Ser Glu Thr Ala Ala Lys Gly Val Asn Thr 
    370                 375                 380                 


Gly Gly Arg Glu Pro Asn Thr Met Val Glu Lys Glu Arg Pro Leu Ala 
385                 390                 395                 400 


Asp Lys Lys Ala Gln Arg Pro Phe Glu Arg Ser Asp Phe Ser Asp Ser 
                405                 410                 415     


Ile Lys Ile Gln Thr Pro Glu Leu Gly Glu Val Phe Gln Asn Lys Asp 
            420                 425                 430         


Ser Asp Tyr Leu Lys Asn Asp Asn Pro Glu Glu His Leu Lys Thr Ser 
        435                 440                 445             


Gly Leu Ala Gly Glu Pro Glu Gly Glu Leu Ser Lys Glu Asp His Glu 
    450                 455                 460                 


Asn Thr Glu Lys Tyr Met Gly Thr Glu Ser Gln Gly Ser Ala Ala Ala 
465                 470                 475                 480 


Glu Pro Glu Asp Asp Ser Phe His Trp Thr Pro His Thr Ser Val Glu 
                485                 490                 495     


Pro Gly His Ser Asp Lys Arg Glu Asp Leu Leu Ile Ile Ser Ser Phe 
            500                 505                 510         


Phe Lys Glu Gln Gln Ser Leu Gln Arg Phe Gln Lys Tyr Phe Asn Val 
        515                 520                 525             


His Glu Leu Glu Ala Leu Leu Gln Glu Met Ser Ser Lys Leu Lys Ser 
    530                 535                 540                 


Ala Gln Gln Glu Ser Leu Pro Tyr Asn Met Glu Lys Val Leu Asp Lys 
545                 550                 555                 560 


Val Phe Arg Ala Ser Glu Ser Gln Ile Leu Ser Ile Ala Glu Lys Met 
                565                 570                 575     


Leu Asp Thr Arg Val Ala Glu Asn Arg Asp Leu Gly Met Asn Glu Asn 
            580                 585                 590         


Asn Ile Phe Glu Glu Ala Ala Val Leu Asp Asp Ile Gln Asp Leu Ile 
        595                 600                 605             


Tyr Phe Val Arg Tyr Lys His Ser Thr Ala Glu Glu Thr Ala Thr Leu 
    610                 615                 620                 


Val Met Ala Pro Pro Leu Glu Glu Gly Leu Gly Gly Ala Met Glu Glu 
625                 630                 635                 640 


Met Gln Pro Leu His Glu Asp Asn Phe Ser Arg Glu Lys Thr Ala Glu 
                645                 650                 655     


Leu Asn Val Gln Val Pro Glu Glu Pro Thr His Leu Asp Gln Arg Val 
            660                 665                 670         


Ile Gly Asp Thr His Ala Ser Glu Val Ser Gln Lys Pro Asn Thr Glu 
        675                 680                 685             


Lys Asp Leu Asp Pro Gly Pro Val Thr Thr Glu Asp Thr Pro Met Asp 
    690                 695                 700                 


Ala Ile Asp Ala Asn Lys Gln Pro Glu Thr Ala Ala Glu Glu Pro Ala 
705                 710                 715                 720 


Ser Val Thr Pro Leu Glu Asn Ala Ile Leu Leu Ile Tyr Ser Phe Met 
                725                 730                 735     


Phe Tyr Leu Thr Lys Ser Leu Val Ala Thr Leu Pro Asp Asp Val Gln 
            740                 745                 750         


Pro Gly Pro Asp Phe Tyr Gly Leu Pro Trp Lys Pro Val Phe Ile Thr 
        755                 760                 765             


Ala Phe Leu Gly Ile Ala Ser Phe Ala Ile Phe Leu Trp Arg Thr Val 
    770                 775                 780                 


Leu Val Val Lys Asp Arg Val Tyr Gln Val Thr Glu Gln Gln Ile Ser 
785                 790                 795                 800 


Glu Lys Leu Lys Thr Ile Met Lys Glu Asn Thr Glu Leu Val Gln Lys 
                805                 810                 815     


Leu Ser Asn Tyr Glu Gln Lys Ile Lys Glu Ser Lys Lys His Val Gln 
            820                 825                 830         


Glu Thr Arg Lys Gln Asn Met Ile Leu Ser Asp Glu Ala Ile Lys Tyr 
        835                 840                 845             


Lys Asp Lys Ile Lys Thr Leu Glu Lys Asn Gln Glu Ile Leu Asp Asp 
    850                 855                 860                 


Thr Ala Lys Asn Leu Arg Val Met Leu Glu Ser Glu Arg Glu Gln Asn 
865                 870                 875                 880 


Val Lys Asn Gln Asp Leu Leu Gln Gln Glu Ile Glu Asp Trp Ser Lys 
                885                 890                 895     


Leu His Ala Glu Leu Ser Glu Gln Ile Lys Ser Phe Glu Lys Ser Gln 
            900                 905                 910         


Lys Asp Leu Glu Val Ala Leu Thr His Lys Asp Asp Asn Ile Asn Ala 
        915                 920                 925             


Leu Thr Asn Cys Ile Thr Gln Leu Asn Leu Leu Glu Cys Glu Ser Glu 
    930                 935                 940                 


Ser Glu Gly Gln Asn Lys Gly Gly Asn Asp Ser Asp Glu Leu Ala Asn 
945                 950                 955                 960 


Gly Glu Val Gly Gly Asp Arg Asn Glu Lys Met Lys Asn Gln Ile Lys 
                965                 970                 975     


Gln Met Met Asp Val Ser Arg Thr Gln Thr Ala Ile Ser Val Val Glu 
            980                 985                 990         


Glu Asp Leu Lys Leu Leu Gln Leu  Lys Leu Arg Ala Ser  Val Ser Thr 
        995                 1000                 1005             


Lys Cys  Asn Leu Glu Asp Gln  Val 
    1010                 1015     


<210>  8714
<211>  107
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8714

Xaa Ser Ala Glu Ala Ser Gly Lys Pro Ser Pro Ser Asp Pro Gly Ser 
1               5                   10                  15      


Gly Thr Ala Thr Met Met Asn Ser Ser Ser Arg Gly Ser Ser Pro Thr 
            20                  25                  30          


Arg Val Leu Asp Glu Gly Lys Val Asn Met Ala Pro Lys Gly Pro Pro 
        35                  40                  45              


Pro Phe Pro Gly Val Pro Leu Met Ser Thr Pro Met Gly Gly Pro Val 
    50                  55                  60                  


Pro Pro Pro Ile Arg Tyr Gly Pro Pro Pro Gln Leu Cys Gly Pro Phe 
65                  70                  75                  80  


Gly Pro Arg Pro Leu Pro Pro Pro Phe Asp Lys Asp Gly Arg Pro Gly 
                85                  90                  95      


Thr Val Ala His Ala Cys Asn Pro Ser Thr Leu 
            100                 105         


<210>  8715
<211>  388
<212>  PRT
<213>  Homo Sapiens

<400>  8715

Met Phe Arg Leu Asn Ser Leu Ser Ala Leu Ala Glu Leu Ala Val Gly 
1               5                   10                  15      


Ser Arg Trp Tyr His Gly Gly Ser Gln Pro Ile Gln Ile Arg Arg Arg 
            20                  25                  30          


Leu Met Met Val Ala Phe Leu Gly Ala Ser Ala Val Thr Ala Ser Thr 
        35                  40                  45              


Gly Leu Leu Trp Lys Arg Ala His Ala Glu Ser Pro Pro Cys Val Asp 
    50                  55                  60                  


Asn Leu Lys Ser Asp Ile Gly Asp Lys Gly Lys Asn Lys Asp Glu Gly 
65                  70                  75                  80  


Asp Val Cys Asn His Glu Lys Lys Thr Ala Asp Leu Ala Pro His Pro 
                85                  90                  95      


Glu Glu Lys Lys Lys Lys Arg Ser Gly Phe Arg Asp Arg Lys Val Met 
            100                 105                 110         


Glu Tyr Glu Asn Arg Ile Arg Ala Tyr Ser Thr Pro Asp Lys Ile Phe 
        115                 120                 125             


Arg Tyr Phe Ala Thr Leu Lys Val Ile Ser Glu Pro Gly Glu Ala Glu 
    130                 135                 140                 


Val Phe Met Thr Pro Glu Asp Phe Val Arg Ser Ile Thr Pro Asn Glu 
145                 150                 155                 160 


Lys Gln Pro Glu His Leu Gly Leu Asp Gln Tyr Ile Ile Lys Arg Phe 
                165                 170                 175     


Asp Gly Lys Ala Arg Phe Ser Lys Lys Lys Ile Leu His Arg Val Arg 
            180                 185                 190         


Lys Lys Ser Lys Gly Ser Ile Leu Gln Arg Arg Lys Lys Ala Leu Gln 
        195                 200                 205             


Lys Glu Glu Arg Thr Arg His Gly Ser Thr Lys His Asn Glu Gln Glu 
    210                 215                 220                 


Val Arg Arg Thr Ile Met Glu Trp Leu Glu Lys Ala Gly Val Gln Trp 
225                 230                 235                 240 


His His Leu Ser Ser Leu Gln Pro Pro Thr Pro Trp Phe Lys Arg Phe 
                245                 250                 255     


Phe Cys Leu Ser Leu Leu Ser Ser Trp Asp Tyr Arg His Thr Pro Pro 
            260                 265                 270         


Cys Pro Ala Asn Phe Phe Ile Phe Ser Arg Asp Arg Val Ser Pro Cys 
        275                 280                 285             


Trp Pro Gly Trp Ser Arg Tyr Pro Asp Leu Met Ile Arg Pro Pro Trp 
    290                 295                 300                 


Leu Arg Lys Val Leu Gly Leu Gln Lys Ile Ser Gln Glu Arg Glu Lys 
305                 310                 315                 320 


Phe Ala Asp Glu Gly Ser Ile Phe Tyr Thr Leu Gly Glu Cys Gly Leu 
                325                 330                 335     


Ile Ser Phe Ser Asp Tyr Ile Phe Leu Thr Thr Val Leu Ser Thr Pro 
            340                 345                 350         


Gln Arg Asn Phe Glu Ile Ala Phe Lys Met Phe Asp Leu Asn Gly Asp 
        355                 360                 365             


Gly Glu Val Asp Met Glu Glu Phe Glu Gln Val Gln Ser Ile Ile Arg 
    370                 375                 380                 


Ser Gln Thr Ser 
385             


<210>  8716
<211>  480
<212>  PRT
<213>  Homo Sapiens

<400>  8716

Met Phe Arg Leu Asn Ser Leu Ser Ala Leu Ala Glu Leu Ala Val Gly 
1               5                   10                  15      


Ser Arg Trp Tyr His Gly Gly Ser Gln Pro Ile Gln Ile Arg Arg Arg 
            20                  25                  30          


Leu Met Met Val Ala Phe Leu Gly Ala Ser Ala Val Thr Ala Ser Thr 
        35                  40                  45              


Gly Leu Leu Trp Lys Arg Ala His Ala Glu Ser Pro Pro Cys Val Asp 
    50                  55                  60                  


Asn Leu Lys Ser Asp Ile Gly Asp Lys Gly Lys Asn Lys Asp Glu Gly 
65                  70                  75                  80  


Asp Val Cys Asn His Glu Lys Lys Thr Ala Asp Leu Ala Pro His Pro 
                85                  90                  95      


Glu Glu Lys Lys Lys Lys Arg Ser Gly Phe Arg Asp Arg Lys Val Met 
            100                 105                 110         


Glu Tyr Glu Asn Arg Ile Arg Ala Tyr Ser Thr Pro Asp Lys Ile Phe 
        115                 120                 125             


Arg Tyr Phe Ala Thr Leu Lys Val Ile Ser Glu Pro Gly Glu Ala Glu 
    130                 135                 140                 


Val Phe Met Thr Pro Glu Asp Phe Val Arg Ser Ile Thr Pro Asn Glu 
145                 150                 155                 160 


Lys Gln Pro Glu His Leu Gly Leu Asp Gln Tyr Ile Ile Lys Arg Phe 
                165                 170                 175     


Asp Gly Lys Asp Phe Trp Gln Lys Ile Ser Gln Glu Arg Glu Lys Phe 
            180                 185                 190         


Ala Asp Glu Gly Ser Ile Phe Tyr Thr Leu Gly Glu Cys Gly Leu Ile 
        195                 200                 205             


Ser Phe Ser Asp Tyr Ile Phe Leu Thr Thr Val Leu Ser Thr Pro Gln 
    210                 215                 220                 


Arg Asn Phe Glu Ile Ala Phe Lys Met Phe Asp Leu Asn Gly Asp Gly 
225                 230                 235                 240 


Glu Val Asp Met Glu Glu Phe Glu Gln Val Gln Ser Ile Ile Arg Ser 
                245                 250                 255     


Gln Thr Ser Met Gly Met Arg His Arg Asp Arg Pro Thr Thr Gly Asn 
            260                 265                 270         


Thr Leu Lys Ser Gly Leu Cys Ser Ala Leu Thr Thr Tyr Phe Phe Gly 
        275                 280                 285             


Ala Asp Leu Lys Gly Lys Leu Thr Ile Lys Asn Phe Leu Glu Phe Gln 
    290                 295                 300                 


Arg Lys Leu Gln His Asp Val Leu Lys Leu Glu Phe Glu Arg His Asp 
305                 310                 315                 320 


Pro Val Asp Gly Arg Ile Thr Glu Arg Gln Phe Gly Gly Met Leu Leu 
                325                 330                 335     


Ala Tyr Ser Gly Val Gln Ser Lys Lys Leu Thr Ala Met Gln Arg Gln 
            340                 345                 350         


Leu Lys Lys His Phe Lys Glu Gly Lys Gly Leu Thr Phe Gln Glu Val 
        355                 360                 365             


Glu Asn Phe Phe Thr Phe Leu Lys Asn Ile Asn Asp Val Asp Thr Ala 
    370                 375                 380                 


Leu Ser Phe Tyr His Met Ala Gly Ala Ser Leu Asp Lys Val Thr Met 
385                 390                 395                 400 


Gln Gln Val Ala Arg Thr Val Ala Lys Val Glu Leu Ser Asp His Val 
                405                 410                 415     


Cys Asp Val Val Phe Ala Leu Phe Asp Cys Asp Gly Asn Gly Glu Leu 
            420                 425                 430         


Ser Asn Lys Glu Phe Val Ser Ile Met Lys Gln Arg Leu Met Arg Gly 
        435                 440                 445             


Leu Glu Lys Pro Lys Asp Met Gly Phe Thr Arg Leu Met Gln Ala Met 
    450                 455                 460                 


Trp Lys Cys Ala Gln Glu Thr Ala Trp Asp Phe Ala Leu Pro Lys Gln 
465                 470                 475                 480 


<210>  8717
<211>  482
<212>  PRT
<213>  Homo Sapiens

<400>  8717

Met Phe Arg Leu Asn Ser Leu Ser Ala Leu Ala Glu Leu Ala Val Gly 
1               5                   10                  15      


Ser Arg Trp Tyr His Gly Gly Ser Gln Pro Ile Gln Ile Arg Arg Arg 
            20                  25                  30          


Leu Met Met Val Ala Phe Leu Gly Ala Ser Ala Val Thr Ala Ser Thr 
        35                  40                  45              


Gly Leu Leu Trp Lys Arg Ala His Ala Glu Ser Pro Pro Cys Val Asp 
    50                  55                  60                  


Asn Leu Lys Ser Asp Ile Gly Asp Lys Gly Lys Asn Lys Asp Glu Gly 
65                  70                  75                  80  


Asp Val Cys Asn His Glu Lys Lys Thr Ala Asp Leu Ala Pro His Pro 
                85                  90                  95      


Glu Glu Lys Lys Lys Lys Arg Ser Gly Phe Arg Asp Arg Lys Val Met 
            100                 105                 110         


Glu Tyr Glu Asn Arg Ile Arg Ala Tyr Ser Thr Pro Asp Lys Ile Phe 
        115                 120                 125             


Arg Tyr Phe Ala Thr Leu Lys Val Ile Ser Glu Pro Gly Glu Ala Glu 
    130                 135                 140                 


Val Phe Met Thr Pro Glu Asp Phe Val Arg Ser Ile Thr Pro Asn Glu 
145                 150                 155                 160 


Lys Gln Pro Glu His Leu Gly Leu Asp Gln Tyr Ile Ile Lys Arg Phe 
                165                 170                 175     


Asp Gly Lys Asp Phe Trp Gln Thr Glu Lys Ile Ser Gln Glu Arg Glu 
            180                 185                 190         


Lys Phe Ala Asp Glu Gly Ser Ile Phe Tyr Thr Leu Gly Glu Cys Gly 
        195                 200                 205             


Leu Ile Ser Phe Ser Asp Tyr Ile Phe Leu Thr Thr Val Leu Ser Thr 
    210                 215                 220                 


Pro Gln Arg Asn Phe Glu Ile Ala Phe Lys Met Phe Asp Leu Asn Gly 
225                 230                 235                 240 


Asp Gly Glu Val Asp Met Glu Glu Phe Glu Gln Val Gln Ser Ile Ile 
                245                 250                 255     


Arg Ser Gln Thr Ser Met Gly Met Arg His Arg Asp Arg Pro Thr Thr 
            260                 265                 270         


Gly Asn Thr Leu Lys Ser Gly Leu Cys Ser Ala Leu Thr Thr Tyr Phe 
        275                 280                 285             


Phe Gly Ala Asp Leu Lys Gly Lys Leu Thr Ile Lys Asn Phe Leu Glu 
    290                 295                 300                 


Phe Gln Arg Lys Leu Gln His Asp Val Leu Lys Leu Glu Phe Glu Arg 
305                 310                 315                 320 


His Asp Pro Val Asp Gly Arg Ile Thr Glu Arg Gln Phe Gly Gly Met 
                325                 330                 335     


Leu Leu Ala Tyr Ser Gly Val Gln Ser Lys Lys Leu Thr Ala Met Gln 
            340                 345                 350         


Arg Gln Leu Lys Lys His Phe Lys Glu Gly Lys Gly Leu Thr Phe Gln 
        355                 360                 365             


Glu Val Glu Asn Phe Phe Thr Phe Leu Lys Asn Ile Asn Asp Val Asp 
    370                 375                 380                 


Thr Ala Leu Ser Phe Tyr His Met Ala Gly Ala Ser Leu Asp Lys Val 
385                 390                 395                 400 


Thr Met Gln Gln Val Ala Arg Thr Val Ala Lys Val Glu Leu Ser Asp 
                405                 410                 415     


His Val Cys Asp Val Val Phe Ala Leu Phe Asp Cys Asp Gly Asn Gly 
            420                 425                 430         


Glu Leu Ser Asn Lys Glu Phe Val Ser Ile Met Lys Gln Arg Leu Met 
        435                 440                 445             


Arg Gly Leu Glu Lys Pro Lys Asp Met Gly Phe Thr Arg Leu Met Gln 
    450                 455                 460                 


Ala Met Trp Lys Cys Ala Gln Glu Thr Ala Trp Asp Phe Ala Leu Pro 
465                 470                 475                 480 


Lys Gln 
        


<210>  8718
<211>  476
<212>  PRT
<213>  Homo Sapiens

<400>  8718

Met Phe Arg Leu Asn Ser Leu Ser Ala Leu Ala Glu Leu Ala Val Gly 
1               5                   10                  15      


Ser Arg Trp Tyr His Gly Gly Ser Gln Pro Ile Gln Ile Arg Arg Arg 
            20                  25                  30          


Leu Met Met Val Ala Phe Leu Gly Ala Ser Ala Val Thr Ala Ser Thr 
        35                  40                  45              


Gly Leu Leu Trp Lys Arg Ala His Ala Glu Ser Pro Pro Cys Val Asp 
    50                  55                  60                  


Asn Leu Lys Ser Asp Ile Gly Asp Lys Gly Lys Asn Lys Asp Glu Gly 
65                  70                  75                  80  


Asp Val Cys Asn His Glu Lys Lys Thr Ala Asp Leu Ala Pro His Pro 
                85                  90                  95      


Glu Glu Lys Lys Lys Lys Arg Ser Gly Phe Arg Asp Arg Lys Val Met 
            100                 105                 110         


Glu Tyr Glu Asn Arg Ile Arg Ala Tyr Ser Thr Pro Asp Lys Ile Phe 
        115                 120                 125             


Arg Tyr Phe Ala Thr Leu Lys Val Ile Ser Glu Pro Gly Glu Ala Glu 
    130                 135                 140                 


Val Phe Met Thr Pro Glu Asp Phe Val Arg Ser Ile Thr Pro Asn Glu 
145                 150                 155                 160 


Lys Gln Pro Glu His Leu Gly Leu Asp Gln Tyr Ile Ile Lys Arg Phe 
                165                 170                 175     


Asp Gly Lys Lys Ile Ser Gln Glu Arg Glu Lys Phe Ala Asp Glu Gly 
            180                 185                 190         


Ser Ile Phe Tyr Thr Leu Gly Glu Cys Gly Leu Ile Ser Phe Ser Asp 
        195                 200                 205             


Tyr Ile Phe Leu Thr Thr Val Leu Ser Thr Pro Gln Arg Asn Phe Glu 
    210                 215                 220                 


Ile Ala Phe Lys Met Phe Asp Leu Asn Gly Asp Gly Glu Val Asp Met 
225                 230                 235                 240 


Glu Glu Phe Glu Gln Val Gln Ser Ile Ile Arg Ser Gln Thr Ser Met 
                245                 250                 255     


Gly Met Arg His Arg Asp Arg Pro Thr Thr Gly Asn Thr Leu Lys Ser 
            260                 265                 270         


Gly Leu Cys Ser Ala Leu Thr Thr Tyr Phe Phe Gly Ala Asp Leu Lys 
        275                 280                 285             


Gly Lys Leu Thr Ile Lys Asn Phe Leu Glu Phe Gln Arg Lys Leu Gln 
    290                 295                 300                 


His Asp Val Leu Lys Leu Glu Phe Glu Arg His Asp Pro Val Asp Gly 
305                 310                 315                 320 


Arg Ile Thr Glu Arg Gln Phe Gly Gly Met Leu Leu Ala Tyr Ser Gly 
                325                 330                 335     


Val Gln Ser Lys Lys Leu Thr Ala Met Gln Arg Gln Leu Lys Lys His 
            340                 345                 350         


Phe Lys Glu Gly Lys Gly Leu Thr Phe Gln Glu Val Glu Asn Phe Phe 
        355                 360                 365             


Thr Phe Leu Lys Asn Ile Asn Asp Val Asp Thr Ala Leu Ser Phe Tyr 
    370                 375                 380                 


His Met Ala Gly Ala Ser Leu Asp Lys Val Thr Met Gln Gln Val Ala 
385                 390                 395                 400 


Arg Thr Val Ala Lys Val Glu Leu Ser Asp His Val Cys Asp Val Val 
                405                 410                 415     


Phe Ala Leu Phe Asp Cys Asp Gly Asn Gly Glu Leu Ser Asn Lys Glu 
            420                 425                 430         


Phe Val Ser Ile Met Lys Gln Arg Leu Met Arg Gly Leu Glu Lys Pro 
        435                 440                 445             


Lys Asp Met Gly Phe Thr Arg Leu Met Gln Ala Met Trp Lys Cys Ala 
    450                 455                 460                 


Gln Glu Thr Ala Trp Asp Phe Ala Leu Pro Lys Gln 
465                 470                 475     


<210>  8719
<211>  478
<212>  PRT
<213>  Homo Sapiens

<400>  8719

Met Phe Arg Leu Asn Ser Leu Ser Ala Leu Ala Glu Leu Ala Val Gly 
1               5                   10                  15      


Ser Arg Trp Tyr His Gly Gly Ser Gln Pro Ile Gln Ile Arg Arg Arg 
            20                  25                  30          


Leu Met Met Val Ala Phe Leu Gly Ala Ser Ala Val Thr Ala Ser Thr 
        35                  40                  45              


Gly Leu Leu Trp Lys Arg Ala His Ala Glu Ser Pro Pro Cys Val Asp 
    50                  55                  60                  


Asn Leu Lys Ser Asp Ile Gly Asp Lys Gly Lys Asn Lys Asp Glu Gly 
65                  70                  75                  80  


Asp Val Cys Asn His Glu Lys Lys Thr Ala Asp Leu Ala Pro His Pro 
                85                  90                  95      


Glu Glu Lys Lys Lys Lys Arg Ser Gly Phe Arg Asp Arg Lys Val Met 
            100                 105                 110         


Glu Tyr Glu Asn Arg Ile Arg Ala Tyr Ser Thr Pro Asp Lys Ile Phe 
        115                 120                 125             


Arg Tyr Phe Ala Thr Leu Lys Val Ile Ser Glu Pro Gly Glu Ala Glu 
    130                 135                 140                 


Val Phe Met Thr Pro Glu Asp Phe Val Arg Ser Ile Thr Pro Asn Glu 
145                 150                 155                 160 


Lys Gln Pro Glu His Leu Gly Leu Asp Gln Tyr Ile Ile Lys Arg Phe 
                165                 170                 175     


Asp Gly Lys Val Lys Lys Ile Ser Gln Glu Arg Glu Lys Phe Ala Asp 
            180                 185                 190         


Glu Gly Ser Ile Phe Tyr Thr Leu Gly Glu Cys Gly Leu Ile Ser Phe 
        195                 200                 205             


Ser Asp Tyr Ile Phe Leu Thr Thr Val Leu Ser Thr Pro Gln Arg Asn 
    210                 215                 220                 


Phe Glu Ile Ala Phe Lys Met Phe Asp Leu Asn Gly Asp Gly Glu Val 
225                 230                 235                 240 


Asp Met Glu Glu Phe Glu Gln Val Gln Ser Ile Ile Arg Ser Gln Thr 
                245                 250                 255     


Ser Met Gly Met Arg His Arg Asp Arg Pro Thr Thr Gly Asn Thr Leu 
            260                 265                 270         


Lys Ser Gly Leu Cys Ser Ala Leu Thr Thr Tyr Phe Phe Gly Ala Asp 
        275                 280                 285             


Leu Lys Gly Lys Leu Thr Ile Lys Asn Phe Leu Glu Phe Gln Arg Lys 
    290                 295                 300                 


Leu Gln His Asp Val Leu Lys Leu Glu Phe Glu Arg His Asp Pro Val 
305                 310                 315                 320 


Asp Gly Arg Ile Thr Glu Arg Gln Phe Gly Gly Met Leu Leu Ala Tyr 
                325                 330                 335     


Ser Gly Val Gln Ser Lys Lys Leu Thr Ala Met Gln Arg Gln Leu Lys 
            340                 345                 350         


Lys His Phe Lys Glu Gly Lys Gly Leu Thr Phe Gln Glu Val Glu Asn 
        355                 360                 365             


Phe Phe Thr Phe Leu Lys Asn Ile Asn Asp Val Asp Thr Ala Leu Ser 
    370                 375                 380                 


Phe Tyr His Met Ala Gly Ala Ser Leu Asp Lys Val Thr Met Gln Gln 
385                 390                 395                 400 


Val Ala Arg Thr Val Ala Lys Val Glu Leu Ser Asp His Val Cys Asp 
                405                 410                 415     


Val Val Phe Ala Leu Phe Asp Cys Asp Gly Asn Gly Glu Leu Ser Asn 
            420                 425                 430         


Lys Glu Phe Val Ser Ile Met Lys Gln Arg Leu Met Arg Gly Leu Glu 
        435                 440                 445             


Lys Pro Lys Asp Met Gly Phe Thr Arg Leu Met Gln Ala Met Trp Lys 
    450                 455                 460                 


Cys Ala Gln Glu Thr Ala Trp Asp Phe Ala Leu Pro Lys Gln 
465                 470                 475             


<210>  8720
<211>  154
<212>  PRT
<213>  Homo Sapiens

<400>  8720

Met Lys Arg Ile Tyr Thr Tyr Arg Arg Ala Lys Glu Ile Phe Lys Asp 
1               5                   10                  15      


Thr Pro Lys Ala Pro Gln Arg Asn Phe Glu Ile Ala Phe Lys Met Phe 
            20                  25                  30          


Asp Leu Asn Gly Asp Gly Glu Val Asp Met Glu Glu Phe Glu Gln Val 
        35                  40                  45              


Gln Ser Ile Ile Arg Ser Gln Thr Ser Met Gly Met Arg His Arg Asp 
    50                  55                  60                  


Arg Pro Thr Thr Gly Asn Thr Leu Lys Ser Gly Leu Cys Ser Ala Leu 
65                  70                  75                  80  


Thr Thr Tyr Phe Phe Gly Ala Asp Leu Lys Gly Lys Leu Thr Ile Lys 
                85                  90                  95      


Asn Phe Leu Glu Phe Gln Arg Lys Leu Gln His Asp Val Leu Lys Leu 
            100                 105                 110         


Glu Phe Glu Arg His Asp Pro Val Asp Gly Arg Ile Thr Glu Arg Gln 
        115                 120                 125             


Phe Gly Gly Met Leu Leu Ala Tyr Ser Gly Val Gln Ser Lys Lys Leu 
    130                 135                 140                 


Thr Ala Met Gln Arg Gln Leu Lys Lys His 
145                 150                 


<210>  8721
<211>  278
<212>  PRT
<213>  Homo Sapiens

<400>  8721

Met Lys Arg Ile Tyr Thr Tyr Arg Arg Ala Lys Glu Ile Phe Lys Asp 
1               5                   10                  15      


Thr Pro Lys Ala Pro Gln Arg Asn Phe Glu Ile Ala Phe Lys Met Phe 
            20                  25                  30          


Asp Leu Asn Gly Asp Gly Glu Val Asp Met Glu Glu Phe Glu Gln Val 
        35                  40                  45              


Gln Ser Ile Ile Arg Ser Gln Thr Ser Met Gly Met Arg His Arg Asp 
    50                  55                  60                  


Arg Pro Thr Thr Gly Asn Thr Leu Lys Ser Gly Leu Cys Ser Ala Leu 
65                  70                  75                  80  


Thr Thr Tyr Phe Phe Gly Ala Asp Leu Lys Gly Lys Leu Thr Ile Lys 
                85                  90                  95      


Asn Phe Leu Glu Phe Gln Arg Lys Leu Gln His Asp Val Leu Lys Leu 
            100                 105                 110         


Glu Phe Glu Arg His Asp Pro Val Asp Gly Arg Ile Thr Glu Arg Gln 
        115                 120                 125             


Phe Gly Gly Met Leu Leu Ala Tyr Ser Gly Val Gln Ser Lys Lys Leu 
    130                 135                 140                 


Thr Ala Met Gln Arg Gln Leu Lys Lys His Phe Lys Glu Gly Lys Gly 
145                 150                 155                 160 


Leu Thr Phe Gln Glu Val Glu Asn Phe Phe Thr Phe Leu Lys Asn Ile 
                165                 170                 175     


Asn Asp Val Asp Thr Ala Leu Ser Phe Tyr His Met Ala Gly Ala Ser 
            180                 185                 190         


Leu Asp Lys Val Thr Met Gln Gln Val Ala Arg Thr Val Ala Lys Val 
        195                 200                 205             


Glu Leu Ser Asp His Val Cys Asp Val Val Phe Ala Leu Phe Asp Cys 
    210                 215                 220                 


Asp Gly Asn Gly Glu Leu Ser Asn Lys Glu Phe Val Ser Ile Met Lys 
225                 230                 235                 240 


Gln Arg Leu Met Arg Gly Leu Glu Lys Pro Lys Asp Met Gly Phe Thr 
                245                 250                 255     


Arg Leu Met Gln Ala Met Trp Lys Cys Ala Gln Glu Thr Ala Trp Asp 
            260                 265                 270         


Phe Ala Leu Pro Lys Gln 
        275             


<210>  8722
<211>  212
<212>  PRT
<213>  Homo Sapiens

<400>  8722

Met Val Ala Phe Leu Gly Ala Ser Ala Val Thr Ala Ser Thr Gly Leu 
1               5                   10                  15      


Leu Trp Lys Arg Ala His Ala Glu Ser Pro Pro Cys Val Asp Asn Leu 
            20                  25                  30          


Lys Ser Asp Ile Gly Asp Lys Gly Lys Asn Lys Asp Glu Gly Asp Val 
        35                  40                  45              


Cys Asn His Glu Lys Lys Thr Ala Asp Leu Ala Pro His Pro Glu Glu 
    50                  55                  60                  


Lys Lys Lys Lys Arg Ser Gly Phe Arg Asp Arg Lys Val Met Glu Tyr 
65                  70                  75                  80  


Glu Asn Arg Ile Arg Ala Tyr Ser Thr Pro Asp Lys Ile Phe Arg Tyr 
                85                  90                  95      


Phe Ala Thr Leu Lys Val Ile Ser Glu Pro Gly Glu Ala Glu Val Phe 
            100                 105                 110         


Met Thr Pro Glu Asp Phe Val Arg Ser Ile Thr Pro Asn Glu Lys Gln 
        115                 120                 125             


Pro Glu His Leu Gly Leu Asp Gln Tyr Ile Ile Lys Arg Phe Asp Gly 
    130                 135                 140                 


Lys Lys Ile Ser Gln Glu Arg Glu Lys Phe Ala Asp Glu Gly Ser Ile 
145                 150                 155                 160 


Phe Tyr Thr Leu Gly Glu Cys Gly Leu Ile Ser Phe Ser Asp Tyr Ile 
                165                 170                 175     


Phe Leu Thr Thr Val Leu Ser Thr Pro Gln Arg Asn Phe Glu Ile Ala 
            180                 185                 190         


Phe Lys Met Phe Asp Leu Asn Gly Asp Gly Glu Val Asp Met Glu Glu 
        195                 200                 205             


Phe Glu Gln Ala 
    210         


<210>  8723
<211>  278
<212>  PRT
<213>  Homo Sapiens

<400>  8723

Met Val Ser Leu Lys Ala Lys Leu Asn His Leu Arg Gln Ser Met Leu 
1               5                   10                  15      


Lys Gln Lys Ala Pro Gln Arg Asn Phe Glu Ile Ala Phe Lys Met Phe 
            20                  25                  30          


Asp Leu Asn Gly Asp Gly Glu Val Asp Met Glu Glu Phe Glu Gln Val 
        35                  40                  45              


Gln Ser Ile Ile Arg Ser Gln Thr Ser Met Gly Met Arg His Arg Asp 
    50                  55                  60                  


Arg Pro Thr Thr Gly Asn Thr Leu Lys Ser Gly Leu Cys Ser Ala Leu 
65                  70                  75                  80  


Thr Thr Tyr Phe Phe Gly Ala Asp Leu Lys Gly Lys Leu Thr Ile Lys 
                85                  90                  95      


Asn Phe Leu Glu Phe Gln Arg Lys Leu Gln His Asp Val Leu Lys Leu 
            100                 105                 110         


Glu Phe Glu Arg His Asp Pro Val Asp Gly Arg Ile Thr Glu Arg Gln 
        115                 120                 125             


Phe Gly Gly Met Leu Leu Ala Tyr Ser Gly Val Gln Ser Lys Lys Leu 
    130                 135                 140                 


Thr Ala Met Gln Arg Gln Leu Lys Lys His Phe Lys Glu Gly Lys Gly 
145                 150                 155                 160 


Leu Thr Phe Gln Glu Val Glu Asn Phe Phe Thr Phe Leu Lys Asn Ile 
                165                 170                 175     


Asn Asp Val Asp Thr Ala Leu Ser Phe Tyr His Met Ala Gly Ala Ser 
            180                 185                 190         


Leu Asp Lys Val Thr Met Gln Gln Val Ala Arg Thr Val Ala Lys Val 
        195                 200                 205             


Glu Leu Ser Asp His Val Cys Asp Val Val Phe Ala Leu Phe Asp Cys 
    210                 215                 220                 


Asp Gly Asn Gly Glu Leu Ser Asn Lys Glu Phe Val Ser Ile Met Lys 
225                 230                 235                 240 


Gln Arg Leu Met Arg Gly Leu Glu Lys Pro Lys Asp Met Gly Phe Thr 
                245                 250                 255     


Arg Leu Met Gln Ala Met Trp Lys Cys Ala Gln Glu Thr Ala Trp Asp 
            260                 265                 270         


Phe Ala Leu Pro Lys Gln 
        275             


<210>  8724
<211>  246
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8724

Xaa Asn Glu Lys Gln Pro Glu His Leu Gly Leu Asp Gln Tyr Ile Ile 
1               5                   10                  15      


Lys Arg Phe Asp Gly Lys Lys Ile Ser Gln Glu Arg Glu Lys Phe Ala 
            20                  25                  30          


Asp Glu Gly Ser Ile Phe Tyr Thr Leu Gly Glu Cys Gly Leu Ile Ser 
        35                  40                  45              


Phe Ser Asp Tyr Ile Phe Leu Thr Thr Val Leu Ser Thr Pro Gln Arg 
    50                  55                  60                  


Asn Phe Glu Ile Ala Phe Lys Met Phe Asp Leu Asn Gly Asp Gly Glu 
65                  70                  75                  80  


Val Asp Met Glu Glu Phe Glu Gln Val Gln Ser Ile Ile Arg Ser Gln 
                85                  90                  95      


Thr Ser Met Gly Met Arg His Arg Asp Arg Pro Thr Thr Gly Asn Thr 
            100                 105                 110         


Leu Lys Ser Gly Leu Cys Ser Ala Leu Thr Thr Tyr Phe Phe Gly Ala 
        115                 120                 125             


Asp Leu Lys Gly Lys Leu Thr Ile Lys Asn Phe Leu Glu Phe Gln Arg 
    130                 135                 140                 


Lys Leu Gln His Asp Val Leu Lys Leu Glu Phe Glu Arg His Asp Pro 
145                 150                 155                 160 


Val Asp Gly Arg Ile Thr Glu Arg Gln Phe Gly Gly Met Leu Leu Ala 
                165                 170                 175     


Tyr Ser Gly Val Gln Ser Lys Lys Leu Thr Ala Met Gln Arg Gln Leu 
            180                 185                 190         


Lys Lys His Phe Lys Glu Gly Lys Gly Leu Thr Phe Gln Glu Val Glu 
        195                 200                 205             


Asn Phe Phe Thr Phe Leu Lys Asn Ile Asn Asp Val Asp Thr Ala Leu 
    210                 215                 220                 


Ser Phe Tyr His Met Ala Gly Ala Ser Leu Asp Lys Gly Lys Gly Thr 
225                 230                 235                 240 


Ile Phe Met Gly Arg Arg 
                245     


<210>  8725
<211>  512
<212>  PRT
<213>  Homo Sapiens

<400>  8725

Met Ala Glu Pro Ser Val Glu Ser Ser Ser Pro Gly Gly Ser Ala Thr 
1               5                   10                  15      


Ser Asp Asp His Glu Phe Asp Pro Ser Ala Asp Met Leu Val His Asp 
            20                  25                  30          


Phe Asp Asp Glu Arg Thr Leu Glu Glu Glu Glu Met Met Glu Gly Glu 
        35                  40                  45              


Thr Asn Phe Ser Ser Glu Ile Glu Asp Leu Ala Arg Glu Gly Asp Met 
    50                  55                  60                  


Pro Ile His Glu Leu Leu Ser Leu Tyr Gly Tyr Gly Ser Thr Val Arg 
65                  70                  75                  80  


Leu Pro Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Glu 
                85                  90                  95      


Asp Asp Glu Asp Ala Asp Asn Asp Asp Asn Ser Gly Cys Ser Gly Glu 
            100                 105                 110         


Asn Lys Glu Glu Asn Ile Lys Asp Ser Ser Gly Gln Glu Asp Glu Thr 
        115                 120                 125             


Gln Ser Ser Asn Asp Asp Pro Ser Gln Ser Val Ala Ser Gln Asp Ala 
    130                 135                 140                 


Gln Glu Ile Ile Arg Pro Arg Arg Cys Lys Tyr Phe Asp Thr Asn Ser 
145                 150                 155                 160 


Glu Val Glu Glu Glu Ser Glu Glu Asp Glu Asp Tyr Ile Pro Ser Glu 
                165                 170                 175     


Asp Trp Lys Lys Glu Ile Met Val Gly Ser Met Phe Gln Ala Glu Ile 
            180                 185                 190         


Pro Val Gly Ile Cys Arg Tyr Lys Glu Asn Glu Lys Val Tyr Glu Asn 
        195                 200                 205             


Asp Asp Gln Leu Leu Trp Asp Pro Glu Tyr Leu Pro Glu Asp Lys Val 
    210                 215                 220                 


Ile Ile Phe Leu Lys Asp Ala Ser Arg Arg Thr Gly Asp Glu Lys Gly 
225                 230                 235                 240 


Val Glu Ala Ile Pro Glu Gly Ser His Ile Lys Asp Asn Glu Gln Ala 
                245                 250                 255     


Leu Tyr Glu Leu Val Lys Cys Asn Phe Asp Thr Glu Glu Ala Leu Arg 
            260                 265                 270         


Arg Leu Arg Phe Asn Val Lys Ala Ala Arg Glu Glu Leu Ser Val Trp 
        275                 280                 285             


Thr Glu Glu Glu Cys Arg Asn Phe Glu Gln Gly Leu Lys Ala Tyr Gly 
    290                 295                 300                 


Lys Asp Phe His Leu Ile Gln Ala Asn Lys Val Arg Thr Arg Ser Val 
305                 310                 315                 320 


Gly Glu Cys Val Ala Phe Tyr Tyr Met Trp Lys Lys Ser Glu Arg Tyr 
                325                 330                 335     


Asp Phe Phe Ala Gln Gln Thr Arg Phe Gly Lys Lys Lys Tyr Asn Leu 
            340                 345                 350         


His Pro Gly Val Thr Asp Tyr Met Asp Arg Leu Leu Asp Glu Ser Glu 
        355                 360                 365             


Ser Ala Ala Ser Ser Arg Ala Pro Ser Pro Pro Pro Thr Ala Ser Asn 
    370                 375                 380                 


Ser Ser Asn Ser Gln Ser Glu Lys Glu Asp Gly Thr Val Ser Thr Ala 
385                 390                 395                 400 


Asn Gln Asn Gly Val Ser Ser Asn Gly Pro Gly Glu Ile Leu Asn Lys 
                405                 410                 415     


Glu Glu Val Lys Val Glu Gly Leu His Ile Asn Gly Pro Thr Gly Gly 
            420                 425                 430         


Asn Lys Lys Pro Leu His Ala Asp Met Asp Thr Asn Gly Tyr Glu Thr 
        435                 440                 445             


Asp Asn Leu Thr Thr Asp Pro Lys Leu Ala His Met Thr Ala Arg Asn 
    450                 455                 460                 


Glu Asn Asp Phe Asp Glu Lys Ser Glu Arg Pro Ala Lys Arg Arg Arg 
465                 470                 475                 480 


Val Asn Ser Asn Gly Lys Glu Ser Pro Gly Ser Ser Glu Phe Phe Gln 
                485                 490                 495     


Glu Ala Val Ser His Gly Lys Phe Glu Glu Leu Glu Asn Thr Asp Asp 
            500                 505                 510         


<210>  8726
<211>  433
<212>  PRT
<213>  Homo Sapiens

<400>  8726

Met Ala Glu Pro Ser Val Glu Ser Ser Ser Pro Gly Gly Ser Ala Thr 
1               5                   10                  15      


Ser Asp Asp His Glu Phe Asp Pro Ser Ala Asp Met Leu Val His Asp 
            20                  25                  30          


Phe Asp Asp Glu Arg Thr Leu Glu Glu Glu Glu Met Met Glu Gly Glu 
        35                  40                  45              


Thr Asn Phe Ser Ser Glu Ile Glu Asp Leu Ala Arg Glu Gly Asp Met 
    50                  55                  60                  


Pro Ile His Glu Leu Leu Ser Leu Tyr Gly Tyr Gly Ser Thr Val Arg 
65                  70                  75                  80  


Leu Pro Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Glu 
                85                  90                  95      


Asp Asp Glu Asp Ala Asp Asn Asp Asp Asn Ser Gly Cys Ser Gly Glu 
            100                 105                 110         


Asn Lys Glu Glu Asn Ile Lys Asp Ser Ser Gly Gln Glu Asp Glu Thr 
        115                 120                 125             


Gln Ser Ser Asn Asp Asp Pro Ser Gln Ser Val Ala Ser Gln Asp Ala 
    130                 135                 140                 


Gln Glu Ile Ile Arg Pro Arg Arg Cys Lys Tyr Phe Asp Thr Asn Ser 
145                 150                 155                 160 


Glu Val Glu Glu Glu Ser Glu Glu Asp Glu Asp Tyr Ile Pro Ser Glu 
                165                 170                 175     


Asp Trp Lys Lys Glu Ile Met Val Gly Ser Met Phe Gln Ala Glu Ile 
            180                 185                 190         


Pro Val Gly Ile Cys Arg Tyr Lys Glu Asn Glu Lys Val Tyr Glu Asn 
        195                 200                 205             


Asp Asp Gln Leu Leu Trp Asp Pro Glu Tyr Leu Pro Glu Asp Lys Val 
    210                 215                 220                 


Ile Ile Phe Leu Lys Asp Ala Ser Arg Arg Thr Gly Asp Glu Lys Gly 
225                 230                 235                 240 


Val Glu Ala Ile Pro Glu Gly Ser His Ile Lys Asp Asn Glu Gln Ala 
                245                 250                 255     


Leu Tyr Glu Leu Val Lys Cys Asn Phe Asp Thr Glu Glu Ala Leu Arg 
            260                 265                 270         


Arg Leu Arg Phe Asn Val Lys Ala Ala Arg Glu Glu Leu Ser Val Trp 
        275                 280                 285             


Thr Glu Glu Glu Cys Arg Asn Phe Glu Gln Gly Leu Lys Ala Tyr Gly 
    290                 295                 300                 


Lys Asp Phe His Leu Ile Gln Ala Asn Lys Val Arg Thr Arg Ser Val 
305                 310                 315                 320 


Gly Glu Cys Val Ala Phe Tyr Tyr Met Trp Lys Lys Ser Glu Arg Tyr 
                325                 330                 335     


Asp Phe Phe Ala Gln Gln Thr Arg Phe Gly Lys Lys Lys Tyr Asn Leu 
            340                 345                 350         


His Pro Gly Val Thr Asp Tyr Met Asp Arg Leu Leu Asp Glu Ser Glu 
        355                 360                 365             


Ser Ala Ala Ser Ser Arg Ala Pro Ser Pro Pro Pro Thr Ala Ser Asn 
    370                 375                 380                 


Ser Ser Asn Ser Gln Ser Glu Lys Glu Asp Gly Thr Val Ser Thr Ala 
385                 390                 395                 400 


Asn Gln Asn Gly Val Ser Ser Asn Gly Pro Gly Ile Leu Gln Met Leu 
                405                 410                 415     


Leu Pro Val His Phe Ser Ala Ile Ser Ser Arg Ala Asn Ala Phe Leu 
            420                 425                 430         


Lys 
    


<210>  8727
<211>  486
<212>  PRT
<213>  Homo Sapiens

<400>  8727

Met Asp Gly Ala Ser Ser Gly Gly Gly Gly Ser Ser Glu Gly Gly Gly 
1               5                   10                  15      


Gly Ser Ser Gly Ser Gly Tyr Gly Val Val Ala Arg Phe Ser Gln Cys 
            20                  25                  30          


Leu Ala Glu Phe Arg Thr Trp Leu Arg Thr Asn Trp Leu Arg Phe Asn 
        35                  40                  45              


Ala Asp Lys Thr Asp Val Met Leu Pro Ser Val Glu Ser Ser Ser Pro 
    50                  55                  60                  


Gly Gly Ser Ala Thr Ser Asp Asp His Glu Phe Asp Pro Ser Ala Asp 
65                  70                  75                  80  


Met Leu Val His Asp Phe Asp Asp Glu Arg Thr Leu Glu Glu Glu Glu 
                85                  90                  95      


Met Met Glu Gly Glu Thr Asn Phe Ser Ser Glu Ile Glu Asp Leu Ala 
            100                 105                 110         


Arg Glu Gly Asp Met Pro Ile His Glu Leu Leu Ser Leu Tyr Gly Tyr 
        115                 120                 125             


Gly Ser Thr Val Arg Leu Pro Glu Glu Asp Glu Glu Glu Glu Glu Glu 
    130                 135                 140                 


Glu Glu Glu Gly Glu Asp Asp Glu Asp Ala Asp Asn Asp Asp Asn Ser 
145                 150                 155                 160 


Gly Cys Ser Gly Glu Asn Lys Glu Glu Asn Ile Lys Asp Ser Ser Gly 
                165                 170                 175     


Gln Glu Asp Glu Thr Gln Ser Ser Asn Asp Asp Pro Ser Gln Ser Val 
            180                 185                 190         


Ala Ser Gln Asp Ala Gln Glu Ile Ile Arg Pro Arg Arg Cys Lys Tyr 
        195                 200                 205             


Phe Asp Thr Asn Ser Glu Val Glu Glu Glu Ser Glu Glu Asp Glu Asp 
    210                 215                 220                 


Tyr Ile Pro Ser Glu Asp Trp Lys Lys Glu Ile Met Val Gly Ser Met 
225                 230                 235                 240 


Phe Gln Ala Glu Ile Pro Val Gly Ile Cys Arg Tyr Lys Glu Asn Glu 
                245                 250                 255     


Lys Val Tyr Glu Asn Asp Asp Gln Leu Leu Trp Asp Pro Glu Tyr Leu 
            260                 265                 270         


Pro Glu Asp Lys Val Ile Ile Phe Leu Lys Asp Ala Ser Arg Arg Thr 
        275                 280                 285             


Gly Asp Glu Lys Gly Val Glu Ala Ile Pro Glu Gly Ser His Ile Lys 
    290                 295                 300                 


Asp Asn Glu Gln Ala Leu Tyr Glu Leu Val Lys Cys Asn Phe Asp Thr 
305                 310                 315                 320 


Glu Glu Ala Leu Arg Arg Leu Arg Phe Asn Val Lys Ala Ala Arg Glu 
                325                 330                 335     


Glu Leu Ser Val Trp Thr Glu Glu Glu Cys Arg Asn Phe Glu Gln Gly 
            340                 345                 350         


Leu Lys Ala Tyr Gly Lys Asp Phe His Leu Ile Gln Ala Asn Lys Val 
        355                 360                 365             


Arg Thr Arg Ser Val Gly Glu Cys Val Ala Phe Tyr Tyr Met Trp Lys 
    370                 375                 380                 


Lys Ser Glu Arg Tyr Asp Phe Phe Ala Gln Gln Thr Arg Phe Gly Lys 
385                 390                 395                 400 


Lys Lys Tyr Asn Leu His Pro Gly Val Thr Asp Tyr Met Asp Arg Leu 
                405                 410                 415     


Leu Asp Glu Ser Glu Ser Ala Ala Ser Ser Arg Ala Pro Ser Pro Pro 
            420                 425                 430         


Pro Thr Ala Ser Asn Ser Ser Asn Ser Gln Ser Glu Lys Glu Asp Gly 
        435                 440                 445             


Thr Val Ser Thr Ala Asn Gln Asn Gly Val Ser Ser Asn Gly Pro Gly 
    450                 455                 460                 


Ile Leu Gln Met Leu Leu Pro Val His Phe Ser Ala Ile Ser Ser Arg 
465                 470                 475                 480 


Ala Asn Ala Phe Leu Lys 
                485     


<210>  8728
<211>  565
<212>  PRT
<213>  Homo Sapiens

<400>  8728

Met Asp Gly Ala Ser Ser Gly Gly Gly Gly Ser Ser Glu Gly Gly Gly 
1               5                   10                  15      


Gly Ser Ser Gly Ser Gly Tyr Gly Val Val Ala Arg Phe Ser Gln Cys 
            20                  25                  30          


Leu Ala Glu Phe Arg Thr Trp Leu Arg Thr Asn Trp Leu Arg Phe Asn 
        35                  40                  45              


Ala Asp Lys Thr Asp Val Met Leu Pro Ser Val Glu Ser Ser Ser Pro 
    50                  55                  60                  


Gly Gly Ser Ala Thr Ser Asp Asp His Glu Phe Asp Pro Ser Ala Asp 
65                  70                  75                  80  


Met Leu Val His Asp Phe Asp Asp Glu Arg Thr Leu Glu Glu Glu Glu 
                85                  90                  95      


Met Met Glu Gly Glu Thr Asn Phe Ser Ser Glu Ile Glu Asp Leu Ala 
            100                 105                 110         


Arg Glu Gly Asp Met Pro Ile His Glu Leu Leu Ser Leu Tyr Gly Tyr 
        115                 120                 125             


Gly Ser Thr Val Arg Leu Pro Glu Glu Asp Glu Glu Glu Glu Glu Glu 
    130                 135                 140                 


Glu Glu Glu Gly Glu Asp Asp Glu Asp Ala Asp Asn Asp Asp Asn Ser 
145                 150                 155                 160 


Gly Cys Ser Gly Glu Asn Lys Glu Glu Asn Ile Lys Asp Ser Ser Gly 
                165                 170                 175     


Gln Glu Asp Glu Thr Gln Ser Ser Asn Asp Asp Pro Ser Gln Ser Val 
            180                 185                 190         


Ala Ser Gln Asp Ala Gln Glu Ile Ile Arg Pro Arg Arg Cys Lys Tyr 
        195                 200                 205             


Phe Asp Thr Asn Ser Glu Val Glu Glu Glu Ser Glu Glu Asp Glu Asp 
    210                 215                 220                 


Tyr Ile Pro Ser Glu Asp Trp Lys Lys Glu Ile Met Val Gly Ser Met 
225                 230                 235                 240 


Phe Gln Ala Glu Ile Pro Val Gly Ile Cys Arg Tyr Lys Glu Asn Glu 
                245                 250                 255     


Lys Val Tyr Glu Asn Asp Asp Gln Leu Leu Trp Asp Pro Glu Tyr Leu 
            260                 265                 270         


Pro Glu Asp Lys Val Ile Ile Phe Leu Lys Asp Ala Ser Arg Arg Thr 
        275                 280                 285             


Gly Asp Glu Lys Gly Val Glu Ala Ile Pro Glu Gly Ser His Ile Lys 
    290                 295                 300                 


Asp Asn Glu Gln Ala Leu Tyr Glu Leu Val Lys Cys Asn Phe Asp Thr 
305                 310                 315                 320 


Glu Glu Ala Leu Arg Arg Leu Arg Phe Asn Val Lys Ala Ala Arg Glu 
                325                 330                 335     


Glu Leu Ser Val Trp Thr Glu Glu Glu Cys Arg Asn Phe Glu Gln Gly 
            340                 345                 350         


Leu Lys Ala Tyr Gly Lys Asp Phe His Leu Ile Gln Ala Asn Lys Val 
        355                 360                 365             


Arg Thr Arg Ser Val Gly Glu Cys Val Ala Phe Tyr Tyr Met Trp Lys 
    370                 375                 380                 


Lys Ser Glu Arg Tyr Asp Phe Phe Ala Gln Gln Thr Arg Phe Gly Lys 
385                 390                 395                 400 


Lys Lys Tyr Asn Leu His Pro Gly Val Thr Asp Tyr Met Asp Arg Leu 
                405                 410                 415     


Leu Asp Glu Ser Glu Ser Ala Ala Ser Ser Arg Ala Pro Ser Pro Pro 
            420                 425                 430         


Pro Thr Ala Ser Asn Ser Ser Asn Ser Gln Ser Glu Lys Glu Asp Gly 
        435                 440                 445             


Thr Val Ser Thr Ala Asn Gln Asn Gly Val Ser Ser Asn Gly Pro Gly 
    450                 455                 460                 


Glu Ile Leu Asn Lys Glu Glu Val Lys Val Glu Gly Leu His Ile Asn 
465                 470                 475                 480 


Gly Pro Thr Gly Gly Asn Lys Lys Pro Leu His Ala Asp Met Asp Thr 
                485                 490                 495     


Asn Gly Tyr Glu Thr Asp Asn Leu Thr Thr Asp Pro Lys Leu Ala His 
            500                 505                 510         


Met Thr Ala Arg Asn Glu Asn Asp Phe Asp Glu Lys Ser Glu Arg Pro 
        515                 520                 525             


Ala Lys Arg Arg Arg Val Asn Ser Asn Gly Lys Glu Ser Pro Gly Ser 
    530                 535                 540                 


Ser Glu Phe Phe Gln Glu Ala Val Ser His Gly Lys Phe Glu Glu Leu 
545                 550                 555                 560 


Glu Asn Thr Asp Asp 
                565 


<210>  8729
<211>  450
<212>  PRT
<213>  Homo Sapiens

<400>  8729

Met Phe Met Phe Asn Trp Phe Thr Asp Cys Leu Trp Thr Leu Phe Leu 
1               5                   10                  15      


Ser Asn Tyr Gln Pro Ser Val Glu Ser Ser Ser Pro Gly Gly Ser Ala 
            20                  25                  30          


Thr Ser Asp Asp His Glu Phe Asp Pro Ser Ala Asp Met Leu Val His 
        35                  40                  45              


Asp Phe Asp Asp Glu Arg Thr Leu Glu Glu Glu Glu Met Met Glu Gly 
    50                  55                  60                  


Glu Thr Asn Phe Ser Ser Glu Ile Glu Asp Leu Ala Arg Glu Gly Asp 
65                  70                  75                  80  


Met Pro Ile His Glu Leu Leu Ser Leu Tyr Gly Tyr Gly Ser Thr Val 
                85                  90                  95      


Arg Leu Pro Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly 
            100                 105                 110         


Glu Asp Asp Glu Asp Ala Asp Asn Asp Asp Asn Ser Gly Cys Ser Gly 
        115                 120                 125             


Glu Asn Lys Glu Glu Asn Ile Lys Asp Ser Ser Gly Gln Glu Asp Glu 
    130                 135                 140                 


Thr Gln Ser Ser Asn Asp Asp Pro Ser Gln Ser Val Ala Ser Gln Asp 
145                 150                 155                 160 


Ala Gln Glu Ile Ile Arg Pro Arg Arg Cys Lys Tyr Phe Asp Thr Asn 
                165                 170                 175     


Ser Glu Val Glu Glu Glu Ser Glu Glu Asp Glu Asp Tyr Ile Pro Ser 
            180                 185                 190         


Glu Asp Trp Lys Lys Glu Ile Met Val Gly Ser Met Phe Gln Ala Glu 
        195                 200                 205             


Ile Pro Val Gly Ile Cys Arg Tyr Lys Glu Asn Glu Lys Val Tyr Glu 
    210                 215                 220                 


Asn Asp Asp Gln Leu Leu Trp Asp Pro Glu Tyr Leu Pro Glu Asp Lys 
225                 230                 235                 240 


Val Ile Ile Phe Leu Lys Asp Ala Ser Arg Arg Thr Gly Asp Glu Lys 
                245                 250                 255     


Gly Val Glu Ala Ile Pro Glu Gly Ser His Ile Lys Asp Asn Glu Gln 
            260                 265                 270         


Ala Leu Tyr Glu Leu Val Lys Cys Asn Phe Asp Thr Glu Glu Ala Leu 
        275                 280                 285             


Arg Arg Leu Arg Phe Asn Val Lys Ala Ala Arg Glu Glu Leu Ser Val 
    290                 295                 300                 


Trp Thr Glu Glu Glu Cys Arg Asn Phe Glu Gln Gly Leu Lys Ala Tyr 
305                 310                 315                 320 


Gly Lys Asp Phe His Leu Ile Gln Ala Asn Lys Val Arg Thr Arg Ser 
                325                 330                 335     


Val Gly Glu Cys Val Ala Phe Tyr Tyr Met Trp Lys Lys Ser Glu Arg 
            340                 345                 350         


Tyr Asp Phe Phe Ala Gln Gln Thr Arg Phe Gly Lys Lys Lys Tyr Asn 
        355                 360                 365             


Leu His Pro Gly Val Thr Asp Tyr Met Asp Arg Leu Leu Asp Glu Ser 
    370                 375                 380                 


Glu Ser Ala Ala Ser Ser Arg Ala Pro Ser Pro Pro Pro Thr Ala Ser 
385                 390                 395                 400 


Asn Ser Ser Asn Ser Gln Ser Glu Lys Glu Asp Gly Thr Val Ser Thr 
                405                 410                 415     


Ala Asn Gln Asn Gly Val Ser Ser Asn Gly Pro Gly Ile Leu Gln Met 
            420                 425                 430         


Leu Leu Pro Val His Phe Ser Ala Ile Ser Ser Arg Ala Asn Ala Phe 
        435                 440                 445             


Leu Lys 
    450 


<210>  8730
<211>  470
<212>  PRT
<213>  Homo Sapiens

<400>  8730

Met Phe Met Phe Asn Trp Phe Thr Asp Cys Leu Trp Thr Leu Phe Leu 
1               5                   10                  15      


Ser Asn Tyr Gln Pro Ser Val Glu Ser Ser Ser Pro Gly Gly Ser Ala 
            20                  25                  30          


Thr Ser Asp Asp His Glu Phe Asp Pro Ser Ala Asp Met Leu Val His 
        35                  40                  45              


Asp Phe Asp Asp Glu Arg Thr Leu Glu Glu Glu Glu Met Met Glu Gly 
    50                  55                  60                  


Glu Thr Asn Phe Ser Ser Glu Ile Glu Asp Leu Ala Arg Glu Gly Asp 
65                  70                  75                  80  


Met Pro Ile His Glu Leu Leu Ser Leu Tyr Gly Tyr Gly Ser Thr Val 
                85                  90                  95      


Arg Leu Pro Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly 
            100                 105                 110         


Glu Asp Asp Glu Asp Ala Asp Asn Asp Asp Asn Ser Gly Cys Ser Gly 
        115                 120                 125             


Glu Asn Lys Glu Glu Asn Ile Lys Asp Ser Ser Gly Gln Glu Asp Glu 
    130                 135                 140                 


Thr Gln Ser Ser Asn Asp Asp Pro Ser Gln Ser Val Ala Ser Gln Asp 
145                 150                 155                 160 


Ala Gln Glu Ile Ile Arg Pro Arg Arg Cys Lys Tyr Phe Asp Thr Asn 
                165                 170                 175     


Ser Glu Val Glu Glu Glu Ser Glu Glu Asp Glu Asp Tyr Ile Pro Ser 
            180                 185                 190         


Glu Asp Trp Lys Lys Glu Ile Met Val Gly Ser Met Phe Gln Ala Glu 
        195                 200                 205             


Ile Pro Val Gly Ile Cys Arg Tyr Lys Glu Asn Glu Lys Val Tyr Glu 
    210                 215                 220                 


Asn Asp Asp Gln Leu Leu Trp Asp Pro Glu Tyr Leu Pro Glu Asp Lys 
225                 230                 235                 240 


Val Ile Ile Phe Leu Lys Asp Ala Ser Arg Arg Thr Gly Asp Glu Lys 
                245                 250                 255     


Gly Val Glu Ala Ile Pro Glu Gly Ser His Ile Lys Asp Asn Glu Gln 
            260                 265                 270         


Ala Leu Tyr Glu Leu Val Lys Cys Asn Phe Asp Thr Glu Glu Ala Leu 
        275                 280                 285             


Arg Arg Leu Arg Phe Asn Val Lys Ala Ala Arg Glu Glu Leu Ser Val 
    290                 295                 300                 


Trp Thr Glu Glu Glu Cys Arg Asn Phe Glu Gln Gly Leu Lys Ala Tyr 
305                 310                 315                 320 


Gly Lys Asp Phe His Leu Ile Gln Ala Asn Lys Val Arg Thr Arg Ser 
                325                 330                 335     


Val Gly Glu Cys Val Ala Phe Tyr Tyr Met Trp Lys Lys Ser Glu Arg 
            340                 345                 350         


Tyr Asp Phe Phe Ala Gln Gln Thr Arg Phe Gly Lys Lys Lys Tyr Asn 
        355                 360                 365             


Leu His Pro Gly Val Thr Asp Tyr Met Asp Arg Leu Leu Asp Glu Ser 
    370                 375                 380                 


Glu Ser Ala Ala Ser Ser Arg Ala Pro Ser Pro Pro Pro Thr Ala Ser 
385                 390                 395                 400 


Asn Ser Ser Asn Ser Gln Ser Glu Lys Glu Asp Gly Thr Val Ser Thr 
                405                 410                 415     


Ala Asn Gln Asn Gly Val Ser Ser Asn Gly Pro Gly Glu Ile Leu Asn 
            420                 425                 430         


Lys Glu Glu Val Lys Val Glu Gly Leu His Ile Asn Gly Pro Thr Gly 
        435                 440                 445             


Ile Leu Gln Met Leu Leu Pro Val His Phe Ser Ala Ile Ser Ser Arg 
    450                 455                 460                 


Ala Asn Ala Phe Leu Lys 
465                 470 


<210>  8731
<211>  529
<212>  PRT
<213>  Homo Sapiens

<400>  8731

Met Phe Met Phe Asn Trp Phe Thr Asp Cys Leu Trp Thr Leu Phe Leu 
1               5                   10                  15      


Ser Asn Tyr Gln Pro Ser Val Glu Ser Ser Ser Pro Gly Gly Ser Ala 
            20                  25                  30          


Thr Ser Asp Asp His Glu Phe Asp Pro Ser Ala Asp Met Leu Val His 
        35                  40                  45              


Asp Phe Asp Asp Glu Arg Thr Leu Glu Glu Glu Glu Met Met Glu Gly 
    50                  55                  60                  


Glu Thr Asn Phe Ser Ser Glu Ile Glu Asp Leu Ala Arg Glu Gly Asp 
65                  70                  75                  80  


Met Pro Ile His Glu Leu Leu Ser Leu Tyr Gly Tyr Gly Ser Thr Val 
                85                  90                  95      


Arg Leu Pro Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly 
            100                 105                 110         


Glu Asp Asp Glu Asp Ala Asp Asn Asp Asp Asn Ser Gly Cys Ser Gly 
        115                 120                 125             


Glu Asn Lys Glu Glu Asn Ile Lys Asp Ser Ser Gly Gln Glu Asp Glu 
    130                 135                 140                 


Thr Gln Ser Ser Asn Asp Asp Pro Ser Gln Ser Val Ala Ser Gln Asp 
145                 150                 155                 160 


Ala Gln Glu Ile Ile Arg Pro Arg Arg Cys Lys Tyr Phe Asp Thr Asn 
                165                 170                 175     


Ser Glu Val Glu Glu Glu Ser Glu Glu Asp Glu Asp Tyr Ile Pro Ser 
            180                 185                 190         


Glu Asp Trp Lys Lys Glu Ile Met Val Gly Ser Met Phe Gln Ala Glu 
        195                 200                 205             


Ile Pro Val Gly Ile Cys Arg Tyr Lys Glu Asn Glu Lys Val Tyr Glu 
    210                 215                 220                 


Asn Asp Asp Gln Leu Leu Trp Asp Pro Glu Tyr Leu Pro Glu Asp Lys 
225                 230                 235                 240 


Val Ile Ile Phe Leu Lys Asp Ala Ser Arg Arg Thr Gly Asp Glu Lys 
                245                 250                 255     


Gly Val Glu Ala Ile Pro Glu Gly Ser His Ile Lys Asp Asn Glu Gln 
            260                 265                 270         


Ala Leu Tyr Glu Leu Val Lys Cys Asn Phe Asp Thr Glu Glu Ala Leu 
        275                 280                 285             


Arg Arg Leu Arg Phe Asn Val Lys Ala Ala Arg Glu Glu Leu Ser Val 
    290                 295                 300                 


Trp Thr Glu Glu Glu Cys Arg Asn Phe Glu Gln Gly Leu Lys Ala Tyr 
305                 310                 315                 320 


Gly Lys Asp Phe His Leu Ile Gln Ala Asn Lys Val Arg Thr Arg Ser 
                325                 330                 335     


Val Gly Glu Cys Val Ala Phe Tyr Tyr Met Trp Lys Lys Ser Glu Arg 
            340                 345                 350         


Tyr Asp Phe Phe Ala Gln Gln Thr Arg Phe Gly Lys Lys Lys Tyr Asn 
        355                 360                 365             


Leu His Pro Gly Val Thr Asp Tyr Met Asp Arg Leu Leu Asp Glu Ser 
    370                 375                 380                 


Glu Ser Ala Ala Ser Ser Arg Ala Pro Ser Pro Pro Pro Thr Ala Ser 
385                 390                 395                 400 


Asn Ser Ser Asn Ser Gln Ser Glu Lys Glu Asp Gly Thr Val Ser Thr 
                405                 410                 415     


Ala Asn Gln Asn Gly Val Ser Ser Asn Gly Pro Gly Glu Ile Leu Asn 
            420                 425                 430         


Lys Glu Glu Val Lys Val Glu Gly Leu His Ile Asn Gly Pro Thr Gly 
        435                 440                 445             


Gly Asn Lys Lys Pro Leu His Ala Asp Met Asp Thr Asn Gly Tyr Glu 
    450                 455                 460                 


Thr Asp Asn Leu Thr Thr Asp Pro Lys Leu Ala His Met Thr Ala Arg 
465                 470                 475                 480 


Asn Glu Asn Asp Phe Asp Glu Lys Ser Glu Arg Pro Ala Lys Arg Arg 
                485                 490                 495     


Arg Val Asn Ser Asn Gly Lys Glu Ser Pro Gly Ser Ser Glu Phe Phe 
            500                 505                 510         


Gln Glu Ala Val Ser His Gly Lys Phe Glu Glu Leu Glu Asn Thr Asp 
        515                 520                 525             


Asp 
    


<210>  8732
<211>  81
<212>  PRT
<213>  Homo Sapiens

<400>  8732

Met Phe Met Phe Asn Trp Phe Thr Asp Cys Leu Trp Thr Leu Phe Leu 
1               5                   10                  15      


Ser Asn Tyr Gln Pro Ser Val Glu Ser Ser Ser Pro Gly Gly Ser Ala 
            20                  25                  30          


Thr Ser Asp Asp His Glu Phe Asp Pro Ser Ala Asp Met Leu Val His 
        35                  40                  45              


Asp Phe Asp Asp Glu Arg Thr Leu Glu Glu Glu Glu Met Met Glu Gly 
    50                  55                  60                  


Glu Thr Asn Phe Ser Ser Glu Ile Glu Asp Leu Ala Arg Val Asn Asn 
65                  70                  75                  80  


Met 
    


<210>  8733
<211>  370
<212>  PRT
<213>  Homo Sapiens

<400>  8733

Met Pro Ile His Glu Leu Leu Ser Leu Tyr Gly Tyr Gly Ser Thr Val 
1               5                   10                  15      


Arg Leu Pro Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly 
            20                  25                  30          


Glu Asp Asp Glu Asp Ala Asp Asn Asp Asp Asn Ser Gly Cys Ser Gly 
        35                  40                  45              


Glu Asn Lys Glu Glu Asn Ile Lys Asp Ser Ser Gly Gln Glu Asp Glu 
    50                  55                  60                  


Thr Gln Ser Ser Asn Asp Asp Pro Ser Gln Ser Val Ala Ser Gln Asp 
65                  70                  75                  80  


Ala Gln Glu Ile Ile Arg Pro Arg Arg Cys Lys Tyr Phe Asp Thr Asn 
                85                  90                  95      


Ser Glu Val Glu Glu Glu Ser Glu Glu Asp Glu Asp Tyr Ile Pro Ser 
            100                 105                 110         


Glu Asp Trp Lys Lys Glu Ile Met Val Gly Ser Met Phe Gln Ala Glu 
        115                 120                 125             


Ile Pro Val Gly Ile Cys Arg Tyr Lys Glu Asn Glu Lys Val Tyr Glu 
    130                 135                 140                 


Asn Asp Asp Gln Leu Leu Trp Asp Pro Glu Tyr Leu Pro Glu Asp Lys 
145                 150                 155                 160 


Val Ile Ile Phe Leu Lys Asp Ala Ser Arg Arg Thr Gly Asp Glu Lys 
                165                 170                 175     


Gly Val Glu Ala Ile Pro Glu Gly Ser His Ile Lys Asp Asn Glu Gln 
            180                 185                 190         


Ala Leu Tyr Glu Leu Val Lys Cys Asn Phe Asp Thr Glu Glu Ala Leu 
        195                 200                 205             


Arg Arg Leu Arg Phe Asn Val Lys Ala Ala Arg Glu Glu Leu Ser Val 
    210                 215                 220                 


Trp Thr Glu Glu Glu Cys Arg Asn Phe Glu Gln Gly Leu Lys Ala Tyr 
225                 230                 235                 240 


Gly Lys Asp Phe His Leu Ile Gln Ala Asn Lys Val Arg Thr Arg Ser 
                245                 250                 255     


Val Gly Glu Cys Val Ala Phe Tyr Tyr Met Trp Lys Lys Ser Glu Arg 
            260                 265                 270         


Tyr Asp Phe Phe Ala Gln Gln Thr Arg Phe Gly Lys Lys Lys Tyr Asn 
        275                 280                 285             


Leu His Pro Gly Val Thr Asp Tyr Met Asp Arg Leu Leu Asp Glu Ser 
    290                 295                 300                 


Glu Ser Ala Ala Ser Ser Arg Ala Pro Ser Pro Pro Pro Thr Ala Ser 
305                 310                 315                 320 


Asn Ser Ser Asn Ser Gln Ser Glu Lys Glu Asp Gly Thr Val Ser Thr 
                325                 330                 335     


Ala Asn Gln Asn Gly Val Ser Ser Asn Gly Pro Gly Ile Leu Gln Met 
            340                 345                 350         


Leu Leu Pro Val His Phe Ser Ala Ile Ser Ser Arg Ala Asn Ala Phe 
        355                 360                 365             


Leu Lys 
    370 


<210>  8734
<211>  70
<212>  PRT
<213>  Homo Sapiens

<400>  8734

Met Phe Gln Pro Leu Ser Ser Pro Asp Ser His Arg Lys Gly Thr Gly 
1               5                   10                  15      


Phe Gly Leu Gly Ile Val Phe Ser Leu Thr Phe Phe Lys Arg Arg Met 
            20                  25                  30          


Trp Pro Leu Ala Phe Gly Ser Gly Met Gly Leu Gly Met Ala Tyr Ser 
        35                  40                  45              


Asn Cys Gln His Asp Phe Gln Ala Pro Tyr Leu Leu His Gly Lys Tyr 
    50                  55                  60                  


Val Lys Glu Gln Glu Gln 
65                  70  


<210>  8735
<211>  71
<212>  PRT
<213>  Homo Sapiens

<400>  8735

Arg Lys Trp Asp Arg Cys Leu Ala Asp Ala Val Val Lys Ile Gly Thr 
1               5                   10                  15      


Gly Phe Gly Leu Gly Ile Val Phe Ser Leu Thr Phe Phe Lys Arg Arg 
            20                  25                  30          


Met Trp Pro Leu Ala Phe Gly Ser Gly Met Gly Leu Gly Met Ala Tyr 
        35                  40                  45              


Ser Asn Cys Gln His Asp Phe Gln Ala Pro Tyr Leu Leu His Gly Lys 
    50                  55                  60                  


Tyr Val Lys Glu Gln Glu Gln 
65                  70      


<210>  8736
<211>  46
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8736

Xaa Lys Trp Asp Arg Cys Leu Ala Asp Ala Val Val Lys Ile Glu Met 
1               5                   10                  15      


Gly Phe His His Val Ala Gln Ala Gly Leu Glu Leu Arg Val Gln Thr 
            20                  25                  30          


Ile His Leu Pro Trp Pro Pro Asn Val Pro Gly Leu Gln Ala 
        35                  40                  45      


<210>  8737
<211>  286
<212>  PRT
<213>  Homo Sapiens

<400>  8737

Met Cys Leu Phe Gln Leu Cys Gly Leu Val Arg Tyr Met Glu Phe Gly 
1               5                   10                  15      


Pro Pro Thr Val Asn Asp Lys Leu Met Arg Phe Phe Asp His Cys Glu 
            20                  25                  30          


Lys Phe Leu Thr Glu Val Glu Lys Asn Ala Thr Ala Leu Tyr His Val 
        35                  40                  45              


Glu Ala Phe Lys Thr Gly Pro Glu Met Gln Asn Ile Leu Lys Lys Val 
    50                  55                  60                  


Ala Ala Thr Leu Gln Val Pro Val Asn Asp Leu Asn Ala Asp Leu Ile 
65                  70                  75                  80  


Gln Val Ala Phe Phe Thr Cys Ser Phe Asp Leu Ala Ile Lys Gly Val 
                85                  90                  95      


Lys Ser Pro Trp Cys Asp Val Phe Asp Ile Asp Asp Ala Lys Val Leu 
            100                 105                 110         


Glu Tyr Leu Asn Asp Leu Lys Gln Tyr Trp Lys Arg Gly Tyr Gly Tyr 
        115                 120                 125             


Thr Ile Asn Ser Arg Ser Ser Cys Thr Leu Phe Gln Asp Ile Phe Gln 
    130                 135                 140                 


His Leu Asp Lys Ala Val Glu Gln Lys Gln Arg Ser Gln Pro Ile Ser 
145                 150                 155                 160 


Ser Pro Val Ile Leu Gln Phe Gly His Ala Glu Thr Leu Leu Pro Leu 
                165                 170                 175     


Leu Ser Leu Met Gly Tyr Phe Lys Asp Lys Glu Pro Leu Thr Ala Tyr 
            180                 185                 190         


Asn Tyr Lys Lys Gln Met His Arg Lys Phe Arg Ser Gly Leu Ile Val 
        195                 200                 205             


Pro Tyr Ala Ser Asn Leu Ile Phe Val Leu Tyr His Cys Glu Asn Ala 
    210                 215                 220                 


Lys Thr Pro Lys Glu Gln Phe Arg Val Gln Met Leu Leu Asn Glu Lys 
225                 230                 235                 240 


Val Leu Pro Leu Ala Tyr Ser Gln Glu Thr Val Ser Phe Tyr Glu Asp 
                245                 250                 255     


Leu Lys Asn His Tyr Lys Asp Ile Leu Gln Ser Cys Gln Thr Ser Glu 
            260                 265                 270         


Glu Cys Glu Leu Ala Arg Ala Asn Ser Thr Ser Asp Glu Leu 
        275                 280                 285     


<210>  8738
<211>  312
<212>  PRT
<213>  Homo Sapiens

<400>  8738

Met Leu Arg Ala Pro Gly Cys Leu Leu Arg Thr Ser Val Ala Pro Ala 
1               5                   10                  15      


Ala Ala Leu Ala Ala Ala Leu Leu Ser Ser Leu Ala Arg Cys Ser Leu 
            20                  25                  30          


Leu Glu Pro Arg Asp Pro Val Ala Ser Ser Leu Ser Pro Tyr Phe Gly 
        35                  40                  45              


Thr Lys Thr Arg Tyr Glu Asp Val Asn Pro Val Leu Leu Ser Gly Pro 
    50                  55                  60                  


Glu Ala Pro Trp Arg Asp Pro Glu Leu Leu Glu Gly Thr Cys Thr Pro 
65                  70                  75                  80  


Val Gln Leu Val Ala Leu Ile Arg His Gly Thr Arg Tyr Pro Thr Val 
                85                  90                  95      


Lys Gln Ile Arg Lys Leu Arg Gln Leu His Gly Leu Leu Gln Ala Arg 
            100                 105                 110         


Gly Ser Arg Asp Gly Gly Ala Ser Ser Thr Gly Ser Arg Asp Leu Gly 
        115                 120                 125             


Ala Ala Leu Ala Asp Trp Pro Leu Trp Tyr Ala Asp Trp Met Asp Gly 
    130                 135                 140                 


Gln Leu Val Glu Lys Gly Arg Gln Asp Met Arg Gln Leu Ala Leu Arg 
145                 150                 155                 160 


Leu Ala Ser Leu Phe Pro Ala Leu Phe Ser Arg Glu Asn Tyr Gly Arg 
                165                 170                 175     


Leu Arg Leu Ile Thr Ser Ser Lys His Arg Cys Met Asp Ser Ser Ala 
            180                 185                 190         


Ala Phe Leu Gln Gly Leu Trp Gln His Tyr His Pro Gly Leu Pro Pro 
        195                 200                 205             


Pro Asp Val Ala Asp Met Glu Phe Gly Pro Pro Thr Val Asn Asp Lys 
    210                 215                 220                 


Leu Met Arg Phe Phe Asp His Cys Glu Lys Phe Leu Thr Glu Val Glu 
225                 230                 235                 240 


Lys Asn Ala Thr Ala Leu Tyr His Val Glu Ala Phe Lys Thr Gly Pro 
                245                 250                 255     


Glu Met Gln Asn Ile Leu Lys Lys Val Ala Ala Thr Leu Gln Val Pro 
            260                 265                 270         


Val Asn Asp Leu Asn Ala Gly Leu Ser Gln Phe Leu Leu Gln Ser Ser 
        275                 280                 285             


Ser Ser Leu Val Met Gln Arg Leu Phe Phe His Cys Phe Leu Ser Trp 
    290                 295                 300                 


Ala Thr Ser Lys Thr Arg Asn Pro 
305                 310         


<210>  8739
<211>  487
<212>  PRT
<213>  Homo Sapiens

<400>  8739

Met Leu Arg Ala Pro Gly Cys Leu Leu Arg Thr Ser Val Ala Pro Ala 
1               5                   10                  15      


Ala Ala Leu Ala Ala Ala Leu Leu Ser Ser Leu Ala Arg Cys Ser Leu 
            20                  25                  30          


Leu Glu Pro Arg Asp Pro Val Ala Ser Ser Leu Ser Pro Tyr Phe Gly 
        35                  40                  45              


Thr Lys Thr Arg Tyr Glu Asp Val Asn Pro Val Leu Leu Ser Gly Pro 
    50                  55                  60                  


Glu Ala Pro Trp Arg Asp Pro Glu Leu Leu Glu Gly Thr Cys Thr Pro 
65                  70                  75                  80  


Val Gln Leu Val Ala Leu Ile Arg His Gly Thr Arg Tyr Pro Thr Val 
                85                  90                  95      


Lys Gln Ile Arg Lys Leu Arg Gln Leu His Gly Leu Leu Gln Ala Arg 
            100                 105                 110         


Gly Ser Arg Asp Gly Gly Ala Ser Ser Thr Gly Ser Arg Asp Leu Gly 
        115                 120                 125             


Ala Ala Leu Ala Asp Trp Pro Leu Trp Tyr Ala Asp Trp Met Asp Gly 
    130                 135                 140                 


Gln Leu Val Glu Lys Gly Arg Gln Asp Met Arg Gln Leu Ala Leu Arg 
145                 150                 155                 160 


Leu Ala Ser Leu Phe Pro Ala Leu Phe Ser Arg Glu Asn Tyr Gly Arg 
                165                 170                 175     


Leu Arg Leu Ile Thr Ser Ser Lys His Arg Cys Met Asp Ser Ser Ala 
            180                 185                 190         


Ala Phe Leu Gln Gly Leu Trp Gln His Tyr His Pro Gly Leu Pro Pro 
        195                 200                 205             


Pro Asp Val Ala Asp Met Glu Phe Gly Pro Pro Thr Val Asn Asp Lys 
    210                 215                 220                 


Leu Met Arg Phe Phe Asp His Cys Glu Lys Phe Leu Thr Glu Val Glu 
225                 230                 235                 240 


Lys Asn Ala Thr Ala Leu Tyr His Val Glu Ala Phe Lys Thr Gly Pro 
                245                 250                 255     


Glu Met Gln Asn Ile Leu Lys Lys Val Ala Ala Thr Leu Gln Val Pro 
            260                 265                 270         


Val Asn Asp Leu Asn Ala Asp Leu Ile Gln Val Ala Phe Phe Thr Cys 
        275                 280                 285             


Ser Phe Asp Leu Ala Ile Lys Gly Val Lys Ser Pro Trp Cys Asp Val 
    290                 295                 300                 


Phe Asp Ile Asp Asp Ala Lys Val Leu Glu Tyr Leu Asn Asp Leu Lys 
305                 310                 315                 320 


Gln Tyr Trp Lys Arg Gly Tyr Gly Tyr Thr Ile Asn Ser Arg Ser Ser 
                325                 330                 335     


Cys Thr Leu Phe Gln Asp Ile Phe Gln His Leu Asp Lys Ala Val Glu 
            340                 345                 350         


Gln Lys Gln Arg Ser Gln Pro Ile Ser Ser Pro Val Ile Leu Gln Phe 
        355                 360                 365             


Gly His Ala Glu Thr Leu Leu Pro Leu Leu Ser Leu Met Gly Tyr Phe 
    370                 375                 380                 


Lys Asp Lys Glu Pro Leu Thr Ala Tyr Asn Tyr Lys Lys Gln Met His 
385                 390                 395                 400 


Arg Lys Phe Arg Ser Gly Leu Ile Val Pro Tyr Ala Ser Asn Leu Ile 
                405                 410                 415     


Phe Val Leu Tyr His Cys Glu Asn Ala Lys Thr Pro Lys Glu Gln Phe 
            420                 425                 430         


Arg Val Gln Met Leu Leu Asn Glu Lys Val Leu Pro Leu Ala Tyr Ser 
        435                 440                 445             


Gln Glu Thr Val Ser Phe Tyr Glu Asp Leu Lys Asn His Tyr Lys Asp 
    450                 455                 460                 


Ile Leu Gln Ser Cys Gln Thr Ser Glu Glu Cys Glu Leu Ala Arg Ala 
465                 470                 475                 480 


Asn Ser Thr Ser Asp Glu Leu 
                485         


<210>  8740
<211>  146
<212>  PRT
<213>  Homo Sapiens

<400>  8740

Met Lys Leu Pro Ile Leu Arg Ser Asn Pro Glu Asp Gln Ile Leu Tyr 
1               5                   10                  15      


Gln Thr Glu Arg Tyr Asn Glu Glu Thr Phe Gly Tyr Glu Val Pro Ile 
            20                  25                  30          


Lys Glu Glu Gly Asp Tyr Val Leu Val Leu Lys Phe Ala Glu Val Tyr 
        35                  40                  45              


Phe Ala Gln Ser Gln Gln Lys Val Phe Asp Val Arg Leu Asn Gly His 
    50                  55                  60                  


Val Val Val Lys Asp Leu Asp Ile Phe Asp Arg Val Gly His Ser Thr 
65                  70                  75                  80  


Ala His Asp Glu Ile Ile Pro Met Ser Ile Arg Lys Gly Lys Leu Ser 
                85                  90                  95      


Val Gln Gly Glu Val Ser Thr Phe Thr Gly Lys Leu Tyr Ile Glu Phe 
            100                 105                 110         


Val Lys Gly Tyr Tyr Asp Asn Pro Lys Val Cys Ala Leu Tyr Ile Met 
        115                 120                 125             


Ala Gly Thr Val Asp Asp Val Pro Lys Leu Gln Pro His Pro Gly Leu 
    130                 135                 140                 


Glu Lys 
145     


<210>  8741
<211>  217
<212>  PRT
<213>  Homo Sapiens

<400>  8741

Met Leu Gly Ala Trp Ala Val Glu Gly Thr Ala Val Ala Leu Leu Arg 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Pro Pro Ala Ile Arg Gly Pro Gly Leu Gly 
            20                  25                  30          


Val Ala Gly Val Ala Gly Ala Ala Gly Ala Gly Leu Pro Glu Ser Val 
        35                  40                  45              


Ile Trp Ala Val Asn Ala Gly Gly Glu Ala His Val Asp Val His Gly 
    50                  55                  60                  


Ile His Phe Arg Lys Asp Pro Leu Glu Gly Arg Val Gly Arg Ala Ser 
65                  70                  75                  80  


Asp Tyr Gly Met Lys Leu Pro Ile Leu Arg Ser Asn Pro Glu Asp Gln 
                85                  90                  95      


Ile Leu Tyr Gln Thr Glu Arg Tyr Asn Glu Glu Thr Phe Gly Tyr Glu 
            100                 105                 110         


Val Pro Ile Lys Glu Glu Gly Asp Tyr Val Leu Val Leu Lys Phe Ala 
        115                 120                 125             


Glu Val Tyr Phe Ala Gln Ser Gln Gln Lys Met Tyr Gln Ser Phe Ser 
    130                 135                 140                 


Leu Ile Arg Asp Trp Arg Arg Lys Lys Arg Lys Lys Lys Lys Lys Asn 
145                 150                 155                 160 


Met Met Lys Gly Leu Ile Ser Lys Asn Arg Pro Ile Arg Thr Gly Cys 
                165                 170                 175     


Ser Gln Ala Pro Ala His Pro Thr Pro Met Pro Arg Thr Thr Ala Ala 
            180                 185                 190         


Ser Cys Phe Pro Ser Trp Trp Pro Ser Glu Ser Ser Phe Gln Pro Ser 
        195                 200                 205             


Ser Ala Ser Ala Gly Cys Glu Asn Lys 
    210                 215         


<210>  8742
<211>  292
<212>  PRT
<213>  Homo Sapiens

<400>  8742

Met Leu Gly Ala Trp Ala Val Glu Gly Thr Ala Val Ala Leu Leu Arg 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Pro Pro Ala Ile Arg Gly Pro Gly Leu Gly 
            20                  25                  30          


Val Ala Gly Val Ala Gly Ala Ala Gly Ala Gly Leu Pro Glu Ser Val 
        35                  40                  45              


Ile Trp Ala Val Asn Ala Gly Gly Glu Ala His Val Asp Val His Gly 
    50                  55                  60                  


Ile His Phe Arg Lys Asp Pro Leu Glu Gly Arg Val Gly Arg Ala Ser 
65                  70                  75                  80  


Asp Tyr Gly Met Lys Leu Pro Ile Leu Arg Ser Asn Pro Glu Asp Gln 
                85                  90                  95      


Ile Leu Tyr Gln Thr Glu Arg Tyr Asn Glu Glu Thr Phe Gly Tyr Glu 
            100                 105                 110         


Val Pro Ile Lys Glu Glu Gly Asp Tyr Val Leu Val Leu Lys Phe Ala 
        115                 120                 125             


Glu Val Tyr Phe Ala Gln Ser Gln Gln Lys Val Phe Asp Val Arg Leu 
    130                 135                 140                 


Asn Gly His Val Val Val Lys Asp Leu Asp Ile Phe Asp Arg Val Gly 
145                 150                 155                 160 


His Ser Thr Ala His Asp Glu Ile Ile Pro Met Ser Ile Arg Lys Gly 
                165                 170                 175     


Lys Leu Ser Val Gln Gly Glu Val Ser Thr Phe Thr Gly Lys Leu Tyr 
            180                 185                 190         


Ile Glu Phe Val Lys Gly Tyr Tyr Asp Asn Pro Lys Val Cys Ala Leu 
        195                 200                 205             


Tyr Ile Met Ala Gly Thr Val Asp Asp Val Pro Lys Leu Gln Pro His 
    210                 215                 220                 


Pro Gly Leu Glu Lys Lys Glu Glu Glu Glu Glu Glu Glu Glu Tyr Asp 
225                 230                 235                 240 


Glu Gly Ser Asn Leu Lys Lys Gln Thr Asn Lys Asn Arg Val Gln Ser 
                245                 250                 255     


Gly Pro Arg Thr Pro Asn Pro Tyr Ala Ser Asp Asn Ser Ser Leu Met 
            260                 265                 270         


Phe Pro Ile Leu Val Ala Phe Gly Val Phe Ile Pro Thr Leu Phe Cys 
        275                 280                 285             


Leu Cys Arg Leu 
    290         


<210>  8743
<211>  173
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8743

Xaa Asn Glu Glu Thr Phe Gly Tyr Glu Val Pro Ile Lys Glu Glu Gly 
1               5                   10                  15      


Asp Tyr Val Leu Val Leu Lys Phe Ala Glu Val Tyr Phe Ala Gln Ser 
            20                  25                  30          


Gln Gln Lys Val Phe Asp Val Arg Leu Asn Gly His Val Val Val Lys 
        35                  40                  45              


Asp Leu Asp Ile Phe Asp Arg Val Gly His Ser Thr Ala His Asp Glu 
    50                  55                  60                  


Ile Ile Pro Met Ser Ile Arg Lys Gly Lys Leu Ser Val Gln Gly Glu 
65                  70                  75                  80  


Val Ser Thr Phe Thr Gly Lys Leu Tyr Ile Glu Phe Val Lys Met Tyr 
                85                  90                  95      


Gln Ser Phe Ser Leu Ile Arg Asp Trp Arg Arg Lys Lys Arg Lys Lys 
            100                 105                 110         


Lys Lys Lys Asn Met Met Lys Gly Leu Ile Ser Lys Asn Arg Pro Ile 
        115                 120                 125             


Arg Thr Gly Cys Ser Gln Ala Pro Ala His Pro Thr Pro Met Pro Arg 
    130                 135                 140                 


Thr Thr Ala Ala Ser Cys Phe Pro Ser Trp Trp Pro Ser Glu Ser Ser 
145                 150                 155                 160 


Phe Gln Pro Ser Ser Ala Ser Ala Gly Cys Glu Asn Lys 
                165                 170             


<210>  8744
<211>  115
<212>  PRT
<213>  Homo Sapiens

<400>  8744

Met Val Ser Arg Lys Ala Val Ala Ala Leu Leu Val Val His Val Ala 
1               5                   10                  15      


Ala Met Leu Ala Ser Gln Thr Glu Ala Phe Val Pro Ile Phe Thr Tyr 
            20                  25                  30          


Gly Glu Leu Gln Arg Met Gln Glu Lys Glu Arg Asn Lys Gly Gln Lys 
        35                  40                  45              


Lys Ser Leu Ser Val Trp Gln Arg Ser Gly Glu Glu Gly Pro Val Asp 
    50                  55                  60                  


Pro Ala Glu Pro Ile Arg Glu Glu Glu Asn Glu Met Ile Lys Leu Thr 
65                  70                  75                  80  


Ala Pro Leu Glu Ile Gly Met Arg Met Asn Ser Arg Gln Leu Glu Lys 
                85                  90                  95      


Tyr Pro Ala Thr Leu Glu Gly Leu Leu Ser Glu Met Leu Pro Gln His 
            100                 105                 110         


Ala Ala Lys 
        115 


<210>  8745
<211>  114
<212>  PRT
<213>  Homo Sapiens

<400>  8745

Met Val Ser Arg Lys Ala Val Ala Ala Leu Leu Val Val His Val Ala 
1               5                   10                  15      


Ala Met Leu Ala Ser Gln Thr Glu Ala Phe Val Pro Ile Phe Thr Tyr 
            20                  25                  30          


Gly Glu Leu Gln Arg Met Gln Glu Lys Glu Arg Asn Lys Gly Gln Lys 
        35                  40                  45              


Lys Ser Leu Ser Val Trp Gln Arg Ser Gly Glu Glu Gly Pro Val Asp 
    50                  55                  60                  


Pro Ala Glu Pro Ile Arg Glu Glu Glu Asn Glu Met Ile Lys Leu Thr 
65                  70                  75                  80  


Ala Pro Leu Glu Ile Gly Met Arg Met Asn Ser Arg Gln Leu Glu Lys 
                85                  90                  95      


Tyr Pro Ala Thr Leu Glu Gly Leu Leu Ser Glu Met Leu Pro Gln His 
            100                 105                 110         


Ala Lys 
        


<210>  8746
<211>  108
<212>  PRT
<213>  Homo Sapiens

<400>  8746

Met Val Ser Arg Lys Ala Val Ala Ala Leu Leu Val Val His Val Ala 
1               5                   10                  15      


Ala Met Leu Ala Ser Gln Thr Glu Ala Phe Val Pro Ile Phe Thr Tyr 
            20                  25                  30          


Gly Glu Leu Gln Arg Met Gln Glu Lys Glu Arg Asn Lys Gly Gln Lys 
        35                  40                  45              


Lys Ser Leu Ser Val Trp Gln Arg Ser Gly Glu Glu Gly Pro Val Asp 
    50                  55                  60                  


Pro Ala Glu Pro Ile Arg Glu Glu Glu Asn Glu Met Ile Lys Leu Thr 
65                  70                  75                  80  


Ala Pro Leu Glu Ile Gly Met Arg Met Asn Ser Arg Gln Leu Glu Lys 
                85                  90                  95      


Tyr Pro Ala Thr Leu Glu Gly Leu Leu Thr Ala Lys 
            100                 105             


<210>  8747
<211>  919
<212>  PRT
<213>  Homo Sapiens

<400>  8747

Met Ala Ala Asp Val Phe Met Cys Ser Pro Arg Arg Pro Arg Ser Arg 
1               5                   10                  15      


Gly Arg Gln Val Leu Leu Lys Pro Gln Val Ser Glu Asp Asp Asp Asp 
            20                  25                  30          


Ser Asp Thr Asp Glu Pro Ser Pro Pro Pro Ala Ser Gly Ala Ala Thr 
        35                  40                  45              


Pro Ala Arg Ala His Ala Ser Ala Ala Pro Pro Pro Pro Arg Ala Gly 
    50                  55                  60                  


Pro Gly Arg Glu Glu Pro Pro Arg Arg Gln Gln Ile Ile His Ser Gly 
65                  70                  75                  80  


His Phe Met Val Ser Ser Pro His Arg Glu His Pro Pro Lys Lys Gly 
                85                  90                  95      


Tyr Asp Phe Asp Thr Val Asn Lys Gln Thr Cys Gln Thr Tyr Ser Phe 
            100                 105                 110         


Gly Lys Thr Ser Ser Cys His Leu Ser Ile Asp Ala Ser Leu Thr Lys 
        115                 120                 125             


Leu Phe Glu Cys Met Thr Leu Ala Tyr Ser Gly Lys Leu Val Ser Pro 
    130                 135                 140                 


Lys Trp Lys Asn Phe Lys Gly Leu Lys Leu Gln Trp Arg Asp Lys Ile 
145                 150                 155                 160 


Arg Leu Asn Asn Ala Ile Trp Arg Ala Trp Tyr Met Gln Tyr Leu Glu 
                165                 170                 175     


Lys Arg Lys Asn Pro Val Cys His Phe Val Thr Pro Leu Asp Gly Ser 
            180                 185                 190         


Val Asp Val Asp Glu His Arg Arg Pro Glu Ala Ile Thr Thr Glu Gly 
        195                 200                 205             


Lys Tyr Trp Lys Ser Arg Ile Glu Ile Val Ile Arg Glu Tyr His Lys 
    210                 215                 220                 


Trp Arg Thr Tyr Phe Lys Lys Arg Leu Gln Gln His Lys Asp Glu Asp 
225                 230                 235                 240 


Leu Ser Ser Leu Val Gln Asp Asp Asp Met Leu Tyr Trp His Lys His 
                245                 250                 255     


Gly Asp Gly Trp Lys Thr Pro Val Pro Met Glu Glu Asp Pro Leu Leu 
            260                 265                 270         


Asp Thr Asp Met Leu Met Ser Glu Phe Ser Asp Thr Leu Phe Ser Thr 
        275                 280                 285             


Leu Ser Ser His Gln Pro Val Ala Trp Pro Asn Pro Arg Glu Ile Ala 
    290                 295                 300                 


His Leu Gly Asn Ala Asp Met Ile Gln Pro Gly Leu Ile Pro Leu Gln 
305                 310                 315                 320 


Pro Asn Leu Asp Phe Met Asp Thr Phe Glu Pro Phe Gln Asp Leu Phe 
                325                 330                 335     


Ser Ser Ser Arg Ser Ile Phe Gly Ser Met Leu Pro Ala Ser Ala Ser 
            340                 345                 350         


Ala Pro Val Pro Asp Pro Asn Asn Pro Pro Ala Gln Glu Ser Ile Leu 
        355                 360                 365             


Pro Thr Thr Ala Leu Pro Thr Val Ser Leu Pro Asp Ser Leu Ile Ala 
    370                 375                 380                 


Pro Pro Thr Ala Pro Ser Leu Ala His Met Asp Glu Gln Gly Cys Glu 
385                 390                 395                 400 


His Thr Ser Arg Thr Glu Asp Pro Phe Ile Gln Pro Thr Asp Phe Gly 
                405                 410                 415     


Pro Ser Glu Pro Pro Leu Ser Val Pro Gln Pro Phe Leu Pro Val Phe 
            420                 425                 430         


Thr Met Pro Leu Leu Ser Pro Ser Pro Ala Pro Pro Pro Ile Ser Pro 
        435                 440                 445             


Val Leu Pro Leu Val Pro Pro Pro Ala Thr Ala Leu Asn Pro Pro Ala 
    450                 455                 460                 


Pro Pro Thr Phe His Gln Pro Gln Lys Phe Ala Gly Val Asn Lys Ala 
465                 470                 475                 480 


Pro Ser Val Ile Thr His Thr Ala Ser Ala Thr Leu Thr His Asp Ala 
                485                 490                 495     


Pro Ala Thr Thr Phe Ser Gln Ser Gln Gly Leu Val Ile Thr Thr His 
            500                 505                 510         


His Pro Ala Pro Ser Ala Ala Pro Cys Gly Leu Ala Leu Ser Pro Val 
        515                 520                 525             


Thr Arg Pro Pro Gln Pro Arg Leu Thr Phe Val His Pro Lys Pro Val 
    530                 535                 540                 


Ser Leu Thr Gly Gly Arg Pro Lys Gln Pro His Lys Ile Val Pro Ala 
545                 550                 555                 560 


Pro Lys Pro Glu Pro Val Ser Leu Val Leu Lys Asn Ala Arg Ile Ala 
                565                 570                 575     


Pro Ala Ala Phe Ser Gly Gln Pro Gln Ala Val Ile Met Thr Ser Gly 
            580                 585                 590         


Pro Leu Lys Arg Glu Gly Met Leu Ala Ser Thr Val Ser Gln Ser Asn 
        595                 600                 605             


Val Val Ile Ala Pro Ala Ala Ile Ala Arg Ala Pro Gly Val Pro Glu 
    610                 615                 620                 


Phe His Ser Ser Ile Leu Val Thr Asp Leu Gly His Gly Thr Ser Ser 
625                 630                 635                 640 


Pro Pro Ala Pro Val Ser Arg Leu Phe Pro Ser Thr Ala Gln Asp Pro 
                645                 650                 655     


Leu Gly Lys Gly Glu Gln Val Pro Leu His Gly Gly Ser Pro Gln Val 
            660                 665                 670         


Thr Val Thr Gly Pro Ser Arg Asp Cys Pro Asn Ser Gly Gln Ala Ser 
        675                 680                 685             


Pro Cys Ala Ser Glu Gln Ser Pro Ser Pro Gln Ser Pro Gln Asn Asn 
    690                 695                 700                 


Cys Ser Gly Lys Ser Asp Pro Lys Asn Val Ala Ala Leu Lys Asn Arg 
705                 710                 715                 720 


Gln Met Lys His Ile Ser Ala Glu Gln Lys Arg Arg Phe Asn Ile Lys 
                725                 730                 735     


Met Cys Phe Asp Met Leu Asn Ser Leu Ile Ser Asn Asn Ser Lys Leu 
            740                 745                 750         


Thr Ser His Ala Ile Thr Leu Gln Lys Thr Val Glu Tyr Ile Thr Lys 
        755                 760                 765             


Leu Gln Gln Glu Arg Gly Gln Met Gln Glu Glu Ala Arg Arg Leu Arg 
    770                 775                 780                 


Glu Glu Ile Glu Glu Leu Asn Ala Thr Ile Ile Ser Cys Gln Gln Leu 
785                 790                 795                 800 


Leu Pro Ala Thr Gly Val Pro Val Thr Arg Arg Gln Phe Asp His Met 
                805                 810                 815     


Lys Asp Met Phe Asp Glu Tyr Val Lys Thr Arg Thr Leu Gln Asn Trp 
            820                 825                 830         


Lys Phe Trp Ile Phe Ser Ile Ile Ile Lys Pro Leu Phe Glu Ser Phe 
        835                 840                 845             


Lys Gly Met Val Ser Thr Ser Ser Leu Glu Glu Leu His Arg Thr Ala 
    850                 855                 860                 


Leu Ser Trp Leu Asp Gln His Cys Ser Leu Pro Ile Leu Arg Pro Met 
865                 870                 875                 880 


Val Leu Ser Thr Leu Arg Gln Leu Ser Thr Ser Thr Ser Ile Leu Thr 
                885                 890                 895     


Asp Pro Ala Gln Leu Pro Glu Gln Ala Ser Lys Ala Val Thr Arg Ile 
            900                 905                 910         


Gly Lys Arg Leu Gly Glu Ser 
        915                 


<210>  8748
<211>  217
<212>  PRT
<213>  Homo Sapiens

<400>  8748

Met Asp Glu Gln Gly Cys Glu His Thr Ser Arg Thr Glu Asp Pro Phe 
1               5                   10                  15      


Ile Gln Pro Thr Asp Phe Gly Pro Ser Glu Pro Pro Leu Ser Val Pro 
            20                  25                  30          


Pro Pro Ile Ser Pro Val Leu Pro Leu Val Pro Pro Pro Ala Thr Ala 
        35                  40                  45              


Leu Asn Pro Pro Ala Pro Pro Thr Phe His Gln Pro Gln Lys Phe Ala 
    50                  55                  60                  


Gly Val Asn Lys Ala Pro Ser Val Ile Thr His Thr Ala Ser Ala Thr 
65                  70                  75                  80  


Leu Thr His Asp Ala Pro Ala Thr Thr Phe Ser Gln Ser Gln Gly Leu 
                85                  90                  95      


Val Ile Thr Thr His His Pro Ala Pro Ser Ala Ala Pro Cys Gly Leu 
            100                 105                 110         


Ala Leu Ser Pro Val Thr Arg Pro Pro Gln Pro Arg Leu Thr Phe Val 
        115                 120                 125             


His Pro Lys Pro Val Ser Leu Thr Gly Gly Arg Pro Lys Gln Pro His 
    130                 135                 140                 


Lys Ile Val Pro Ala Pro Lys Pro Glu Pro Val Ser Leu Val Leu Lys 
145                 150                 155                 160 


Asn Ala Arg Ile Ala Pro Gly Glu Pro Gly Gly Glu Thr Gln Cys Gly 
                165                 170                 175     


Ala Pro Pro Asp Pro Glu Gly Cys Phe Pro Ile Pro Lys Ala Phe Lys 
            180                 185                 190         


Leu Val Thr Thr Thr Thr Thr Leu Val Cys Thr Cys Met Arg Thr His 
        195                 200                 205             


Ile His Leu Asn Glu Thr Lys Val Ser 
    210                 215         


<210>  8749
<211>  526
<212>  PRT
<213>  Homo Sapiens

<400>  8749

Met Asp Glu Gln Gly Cys Glu His Thr Ser Arg Thr Glu Asp Pro Phe 
1               5                   10                  15      


Ile Gln Pro Thr Asp Phe Gly Pro Ser Glu Pro Pro Leu Ser Val Pro 
            20                  25                  30          


Gln Pro Phe Leu Pro Val Phe Thr Met Pro Leu Leu Ser Pro Ser Pro 
        35                  40                  45              


Ala Pro Pro Pro Ile Ser Pro Val Leu Pro Leu Val Pro Pro Pro Ala 
    50                  55                  60                  


Thr Ala Leu Asn Pro Pro Ala Pro Pro Thr Phe His Gln Pro Gln Lys 
65                  70                  75                  80  


Phe Ala Gly Val Asn Lys Ala Pro Ser Val Ile Thr His Thr Ala Ser 
                85                  90                  95      


Ala Thr Leu Thr His Asp Ala Pro Ala Thr Thr Phe Ser Gln Ser Gln 
            100                 105                 110         


Gly Leu Val Ile Thr Thr His His Pro Ala Pro Ser Ala Ala Pro Cys 
        115                 120                 125             


Gly Leu Ala Leu Ser Pro Val Thr Arg Pro Pro Gln Pro Arg Leu Thr 
    130                 135                 140                 


Phe Val His Pro Lys Pro Val Ser Leu Thr Gly Gly Arg Pro Lys Gln 
145                 150                 155                 160 


Pro His Lys Ile Val Pro Ala Pro Lys Pro Glu Pro Val Ser Leu Val 
                165                 170                 175     


Leu Lys Asn Ala Arg Ile Ala Pro Ala Ala Phe Ser Gly Gln Pro Gln 
            180                 185                 190         


Ala Val Ile Met Thr Ser Gly Pro Leu Lys Arg Glu Gly Met Leu Ala 
        195                 200                 205             


Ser Thr Val Ser Gln Ser Asn Val Val Ile Ala Pro Ala Ala Ile Ala 
    210                 215                 220                 


Arg Ala Pro Gly Val Pro Glu Phe His Ser Ser Ile Leu Val Thr Asp 
225                 230                 235                 240 


Leu Gly His Gly Thr Ser Ser Pro Pro Ala Pro Val Ser Arg Leu Phe 
                245                 250                 255     


Pro Ser Thr Ala Gln Asp Pro Leu Gly Lys Gly Glu Gln Val Pro Leu 
            260                 265                 270         


His Gly Gly Ser Pro Gln Val Thr Val Thr Gly Pro Ser Arg Asp Cys 
        275                 280                 285             


Pro Asn Ser Gly Gln Ala Ser Pro Cys Ala Ser Glu Gln Ser Pro Ser 
    290                 295                 300                 


Pro Gln Ser Pro Gln Asn Asn Cys Ser Gly Lys Ser Asp Pro Lys Asn 
305                 310                 315                 320 


Val Ala Ala Leu Lys Asn Arg Gln Met Lys His Ile Ser Ala Glu Gln 
                325                 330                 335     


Lys Arg Arg Phe Asn Ile Lys Met Cys Phe Asp Met Leu Asn Ser Leu 
            340                 345                 350         


Ile Ser Asn Asn Ser Lys Leu Thr Ser His Ala Ile Thr Leu Gln Lys 
        355                 360                 365             


Thr Val Glu Tyr Ile Thr Lys Leu Gln Gln Glu Arg Gly Gln Met Gln 
    370                 375                 380                 


Glu Glu Ala Arg Arg Leu Arg Glu Glu Ile Glu Glu Leu Asn Ala Thr 
385                 390                 395                 400 


Ile Ile Ser Cys Gln Gln Leu Leu Pro Ala Thr Gly Val Pro Val Thr 
                405                 410                 415     


Arg Arg Gln Phe Asp His Met Lys Asp Met Phe Asp Glu Tyr Val Lys 
            420                 425                 430         


Thr Arg Thr Leu Gln Asn Trp Lys Phe Trp Ile Phe Ser Ile Ile Ile 
        435                 440                 445             


Lys Pro Leu Phe Glu Ser Phe Lys Gly Met Val Ser Thr Ser Ser Leu 
    450                 455                 460                 


Glu Glu Leu His Arg Thr Ala Leu Ser Trp Leu Asp Gln His Cys Ser 
465                 470                 475                 480 


Leu Pro Ile Leu Arg Pro Met Val Leu Ser Thr Leu Arg Gln Leu Ser 
                485                 490                 495     


Thr Ser Thr Ser Ile Leu Thr Asp Pro Ala Gln Leu Pro Glu Gln Ala 
            500                 505                 510         


Ser Lys Ala Val Thr Arg Ile Gly Lys Arg Leu Gly Glu Ser 
        515                 520                 525     


<210>  8750
<211>  74
<212>  PRT
<213>  Homo Sapiens

<400>  8750

Met Leu Tyr Trp His Lys His Gly Asp Gly Trp Lys Thr Pro Val Pro 
1               5                   10                  15      


Met Glu Glu Asp Pro Leu Leu Asp Thr Asp Met Leu Met Ser Glu Phe 
            20                  25                  30          


Ser Asp Thr Leu Phe Ser Thr Leu Ser Ser His Gln Pro Val Ala Trp 
        35                  40                  45              


Pro Asn Pro Arg Glu Ile Ala His Leu Gly Asn Ala Asp Met Ile Gln 
    50                  55                  60                  


Pro Gly Leu Ile Pro Leu Gln Pro Asn Leu 
65                  70                  


<210>  8751
<211>  308
<212>  PRT
<213>  Homo Sapiens

<400>  8751

Met Val Leu Gly Ala Leu Val Ala Leu Ser Ser Cys Pro Leu Gly Leu 
1               5                   10                  15      


Arg Thr Ser Cys Leu Thr Gly Arg Glu Ala Ala Ser Ala Gly Trp Ala 
            20                  25                  30          


Arg Pro Cys Gly Pro Gly Leu His Leu Asn Ile Leu Leu Ile Leu Ala 
        35                  40                  45              


Ala Ala Phe Ser Gly Gln Pro Gln Ala Val Ile Met Thr Ser Gly Pro 
    50                  55                  60                  


Leu Lys Arg Glu Gly Met Leu Ala Ser Thr Val Ser Gln Ser Asn Val 
65                  70                  75                  80  


Val Ile Ala Pro Ala Ala Ile Ala Arg Ala Pro Gly Val Pro Glu Phe 
                85                  90                  95      


His Ser Ser Ile Leu Val Thr Asp Leu Gly His Gly Thr Ser Ser Pro 
            100                 105                 110         


Pro Ala Pro Val Ser Arg Leu Phe Pro Ser Thr Ala Gln Asp Pro Leu 
        115                 120                 125             


Gly Lys Gly Glu Gln Val Pro Leu His Gly Gly Ser Pro Gln Val Thr 
    130                 135                 140                 


Val Thr Gly Pro Ser Arg Asp Cys Pro Asn Ser Gly Gln Ala Ser Pro 
145                 150                 155                 160 


Cys Ala Ser Glu Gln Ser Pro Ser Pro Gln Ser Pro Gln Asn Asn Cys 
                165                 170                 175     


Ser Gly Lys Ser Asp Pro Lys Asn Val Ala Ala Leu Lys Asn Arg Gln 
            180                 185                 190         


Met Lys His Ile Ser Ala Glu Gln Lys Arg Arg Phe Asn Ile Lys Met 
        195                 200                 205             


Cys Phe Asp Met Leu Asn Ser Leu Ile Ser Asn Asn Ser Lys Leu Thr 
    210                 215                 220                 


Ser His Ala Ile Thr Leu Gln Lys Thr Val Glu Tyr Ile Thr Lys Leu 
225                 230                 235                 240 


Gln Gln Glu Arg Gly Gln Met Gln Glu Glu Ala Arg Arg Leu Arg Glu 
                245                 250                 255     


Glu Ile Glu Glu Leu Asn Ala Thr Ile Ile Ser Cys Gln Gln Leu Leu 
            260                 265                 270         


Pro Ala Thr Gly Val Pro Val Thr Arg Arg Gln Phe Asp His Met Lys 
        275                 280                 285             


Asp Met Phe Asp Glu Tyr Val Lys Thr Arg Thr Leu Gln Asn Trp Lys 
    290                 295                 300                 


Phe Trp Ile Val 
305             


<210>  8752
<211>  171
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8752

Xaa His Gly Gly Ser Pro Gln Val Thr Val Thr Gly Pro Ser Arg Asp 
1               5                   10                  15      


Cys Pro Asn Ser Gly Gln Ala Ser Pro Cys Ala Ser Glu Gln Ser Pro 
            20                  25                  30          


Ser Pro Gln Ser Pro Gln Asn Asn Cys Ser Gly Lys Ser Asp Pro Lys 
        35                  40                  45              


Asn Val Ala Ala Leu Lys Asn Arg Gln Met Lys His Ile Ser Ala Glu 
    50                  55                  60                  


Gln Lys Arg Arg Phe Asn Ile Lys Met Cys Phe Asp Met Leu Asn Ser 
65                  70                  75                  80  


Leu Ile Ser Asn Asn Ser Lys Leu Thr Ser His Ala Ile Thr Leu Gln 
                85                  90                  95      


Lys Thr Val Glu Tyr Ile Thr Lys Leu Gln Gln Glu Arg Gly Gln Met 
            100                 105                 110         


Gln Glu Glu Ala Arg Arg Leu Arg Glu Glu Ile Glu Glu Leu Asn Ala 
        115                 120                 125             


Thr Ile Ile Asp Pro Phe Ser Val Gly Arg Tyr Phe Pro Ala Pro Gly 
    130                 135                 140                 


Glu Arg Ser Thr Pro Val Gln Pro Pro Ser Gly Leu Gln Ser Pro Ala 
145                 150                 155                 160 


Pro Leu Arg Ala Cys Leu Phe Phe Asn His Thr 
                165                 170     


<210>  8753
<211>  213
<212>  PRT
<213>  Homo Sapiens

<400>  8753

Met Ala Gly Ala Leu Ala Gly Leu Ala Ala Gly Leu Gln Val Pro Arg 
1               5                   10                  15      


Val Ala Pro Ser Pro Asp Ser Asp Ser Asp Thr Asp Ser Glu Asp Pro 
            20                  25                  30          


Ser Leu Arg Arg Ser Ala Gly Gly Leu Leu Arg Ser Gln Val Ile His 
        35                  40                  45              


Ser Gly His Phe Met Val Ser Ser Pro His Ser Asp Ser Leu Pro Arg 
    50                  55                  60                  


Arg Arg Asp Gln Glu Gly Ser Val Gly Pro Ser Asp Phe Gly Pro Arg 
65                  70                  75                  80  


Ser Ile Asp Pro Thr Leu Thr Arg Leu Phe Glu Cys Leu Ser Leu Ala 
                85                  90                  95      


Tyr Ser Gly Lys Leu Val Ser Pro Lys Trp Lys Asn Phe Lys Gly Leu 
            100                 105                 110         


Lys Leu Leu Cys Arg Asp Lys Ile Arg Leu Asn Asn Ala Ile Trp Arg 
        115                 120                 125             


Ala Trp Tyr Ile Gln Tyr Phe Phe Thr Asn Ser Arg Leu Pro Gln Pro 
    130                 135                 140                 


Pro Met Pro Ser Asn Phe Pro Glu Pro Pro Ser Phe Ser Pro Val Val 
145                 150                 155                 160 


Asp Ser Leu Phe Ser Ser Gly Thr Leu Gly Pro Glu Val Pro Pro Ala 
                165                 170                 175     


Ser Ser Ala Met Thr His Leu Ser Gly His Ser Arg Leu Gln Ala Arg 
            180                 185                 190         


Asn Ser Cys Pro Gly Pro Leu Asp Ser Ser Ala Phe Leu Ser Ser Asp 
        195                 200                 205             


Phe Leu Leu Pro Glu 
    210             


<210>  8754
<211>  721
<212>  PRT
<213>  Homo Sapiens

<400>  8754

Met Ala Gly Ala Leu Ala Gly Leu Ala Ala Gly Leu Gln Val Pro Arg 
1               5                   10                  15      


Val Ala Pro Ser Pro Asp Ser Asp Ser Asp Thr Asp Ser Glu Asp Pro 
            20                  25                  30          


Ser Leu Arg Arg Ser Ala Gly Gly Leu Leu Arg Ser Gln Val Ile His 
        35                  40                  45              


Ser Gly His Phe Met Val Ser Ser Pro His Ser Asp Ser Leu Pro Arg 
    50                  55                  60                  


Arg Arg Asp Gln Glu Gly Ser Val Gly Pro Ser Asp Phe Gly Pro Arg 
65                  70                  75                  80  


Ser Ile Asp Pro Thr Leu Thr Arg Leu Phe Glu Cys Leu Ser Leu Ala 
                85                  90                  95      


Tyr Ser Gly Lys Leu Val Ser Pro Lys Trp Lys Asn Phe Lys Gly Leu 
            100                 105                 110         


Lys Leu Leu Cys Arg Asp Lys Ile Arg Leu Asn Asn Ala Ile Trp Arg 
        115                 120                 125             


Ala Trp Tyr Ile Gln Tyr Val Lys Arg Arg Lys Ser Pro Val Cys Gly 
    130                 135                 140                 


Phe Val Thr Pro Leu Gln Gly Pro Glu Ala Asp Ala His Arg Lys Pro 
145                 150                 155                 160 


Glu Ala Val Val Leu Glu Gly Asn Tyr Trp Lys Arg Arg Ile Glu Leu 
                165                 170                 175     


Pro Pro Glu Asp Ala Tyr Val Gly Asn Ala Asp Met Ile Gln Pro Asp 
            180                 185                 190         


Leu Thr Pro Leu Gln Pro Ser Leu Asp Asp Phe Met Asp Ile Ser Asp 
        195                 200                 205             


Phe Phe Thr Asn Ser Arg Leu Pro Gln Pro Pro Met Pro Ser Asn Phe 
    210                 215                 220                 


Pro Glu Pro Pro Ser Phe Ser Pro Val Val Asp Ser Leu Phe Ser Ser 
225                 230                 235                 240 


Gly Thr Leu Gly Pro Glu Val Pro Pro Ala Ser Ser Ala Met Thr His 
                245                 250                 255     


Leu Ser Gly His Ser Arg Leu Gln Ala Arg Asn Ser Cys Pro Gly Pro 
            260                 265                 270         


Leu Asp Ser Ser Ala Phe Leu Ser Ser Asp Phe Leu Leu Pro Glu Asp 
        275                 280                 285             


Pro Lys Pro Arg Leu Pro Pro Pro Pro Val Pro Pro Pro Leu Leu His 
    290                 295                 300                 


Tyr Pro Pro Pro Ala Lys Val Pro Gly Leu Glu Pro Cys Pro Pro Pro 
305                 310                 315                 320 


Pro Phe Pro Pro Met Ala Pro Pro Thr Ala Leu Leu Gln Glu Glu Pro 
                325                 330                 335     


Leu Phe Ser Pro Arg Phe Pro Phe Pro Thr Val Pro Pro Ala Pro Gly 
            340                 345                 350         


Val Ser Pro Leu Pro Ala Pro Ala Ala Phe Pro Pro Thr Pro Gln Ser 
        355                 360                 365             


Val Pro Ser Pro Ala Pro Thr Pro Phe Pro Ile Glu Leu Leu Pro Leu 
    370                 375                 380                 


Gly Tyr Ser Glu Pro Ala Phe Gly Pro Cys Phe Ser Met Pro Arg Gly 
385                 390                 395                 400 


Lys Pro Pro Ala Pro Ser Pro Arg Gly Gln Lys Ala Ser Pro Pro Thr 
                405                 410                 415     


Leu Ala Pro Ala Thr Ala Ser Pro Pro Thr Thr Ala Gly Ser Asn Asn 
            420                 425                 430         


Pro Cys Leu Thr Gln Leu Leu Thr Ala Ala Lys Pro Glu Gln Ala Leu 
        435                 440                 445             


Glu Pro Pro Leu Val Ser Ser Thr Leu Leu Arg Ser Pro Gly Ser Pro 
    450                 455                 460                 


Glu Thr Val Pro Glu Phe Pro Cys Thr Phe Leu Pro Pro Thr Pro Ala 
465                 470                 475                 480 


Pro Thr Pro Pro Arg Pro Pro Pro Gly Pro Ala Thr Leu Ala Pro Ser 
                485                 490                 495     


Arg Pro Leu Leu Val Pro Lys Ala Glu Arg Leu Ser Pro Pro Ala Pro 
            500                 505                 510         


Ser Gly Ser Glu Arg Arg Leu Ser Gly Asp Leu Ser Ser Met Pro Gly 
        515                 520                 525             


Pro Gly Thr Leu Ser Val Arg Val Ser Pro Pro Gln Pro Ile Leu Ser 
    530                 535                 540                 


Arg Gly Arg Pro Asp Ser Asn Lys Thr Glu Asn Arg Arg Ile Thr His 
545                 550                 555                 560 


Ile Ser Ala Glu Gln Lys Arg Arg Phe Asn Ile Lys Leu Gly Phe Asp 
                565                 570                 575     


Thr Leu His Gly Leu Val Ser Thr Leu Ser Ala Gln Pro Ser Leu Lys 
            580                 585                 590         


Val Ser Lys Ala Thr Thr Leu Gln Lys Thr Ala Glu Tyr Ile Leu Met 
        595                 600                 605             


Leu Gln Gln Glu Arg Ala Gly Leu Gln Glu Glu Ala Gln Gln Leu Arg 
    610                 615                 620                 


Asp Glu Ile Glu Glu Leu Asn Ala Ala Ile Asn Leu Cys Gln Gln Gln 
625                 630                 635                 640 


Leu Pro Ala Thr Gly Val Pro Ile Thr His Gln Arg Phe Asp Gln Met 
                645                 650                 655     


Arg Asp Met Phe Asp Asp Tyr Val Arg Thr Arg Thr Leu His Asn Trp 
            660                 665                 670         


Lys Phe Trp Val Phe Ser Ile Leu Ile Arg Pro Leu Phe Glu Ser Phe 
        675                 680                 685             


Asn Gly Met Val Ser Thr Ala Ser Val His Thr Leu Arg Gln Thr Ser 
    690                 695                 700                 


Leu Ala Trp Leu Asp Gln Tyr Cys Ser Leu Pro Ala Leu Arg Pro Ser 
705                 710                 715                 720 


Thr 
    


<210>  8755
<211>  852
<212>  PRT
<213>  Homo Sapiens

<400>  8755

Met Ala Gly Ala Leu Ala Gly Leu Ala Ala Gly Leu Gln Val Pro Arg 
1               5                   10                  15      


Val Ala Pro Ser Pro Asp Ser Asp Ser Asp Thr Asp Ser Glu Asp Pro 
            20                  25                  30          


Ser Leu Arg Arg Ser Ala Gly Gly Leu Leu Arg Ser Gln Val Ile His 
        35                  40                  45              


Ser Gly His Phe Met Val Ser Ser Pro His Ser Asp Ser Leu Pro Arg 
    50                  55                  60                  


Arg Arg Asp Gln Glu Gly Ser Val Gly Pro Ser Asp Phe Gly Pro Arg 
65                  70                  75                  80  


Ser Ile Asp Pro Thr Leu Thr Arg Leu Phe Glu Cys Leu Ser Leu Ala 
                85                  90                  95      


Tyr Ser Gly Lys Leu Val Ser Pro Lys Trp Lys Asn Phe Lys Gly Leu 
            100                 105                 110         


Lys Leu Leu Cys Arg Asp Lys Ile Arg Leu Asn Asn Ala Ile Trp Arg 
        115                 120                 125             


Ala Trp Tyr Ile Gln Tyr Val Lys Arg Arg Lys Ser Pro Val Cys Gly 
    130                 135                 140                 


Phe Val Thr Pro Leu Gln Gly Pro Glu Ala Asp Ala His Arg Lys Pro 
145                 150                 155                 160 


Glu Ala Val Val Leu Glu Gly Asn Tyr Trp Lys Arg Arg Ile Glu Val 
                165                 170                 175     


Val Met Arg Glu Tyr His Lys Trp Arg Ile Tyr Tyr Lys Lys Arg Leu 
            180                 185                 190         


Arg Lys Pro Ser Arg Glu Asp Asp Leu Leu Ala Pro Lys Gln Ala Glu 
        195                 200                 205             


Gly Arg Trp Pro Pro Pro Glu Gln Trp Cys Lys Gln Leu Phe Ser Ser 
    210                 215                 220                 


Val Val Pro Val Leu Leu Gly Asp Pro Glu Glu Glu Pro Gly Gly Arg 
225                 230                 235                 240 


Gln Leu Leu Asp Leu Asn Cys Phe Leu Ser Asp Ile Ser Asp Thr Leu 
                245                 250                 255     


Phe Thr Met Thr Gln Ser Gly Pro Ser Pro Leu Gln Leu Pro Pro Glu 
            260                 265                 270         


Asp Ala Tyr Val Gly Asn Ala Asp Met Ile Gln Pro Asp Leu Thr Pro 
        275                 280                 285             


Leu Gln Pro Ser Leu Asp Asp Phe Met Asp Ile Ser Asp Phe Phe Thr 
    290                 295                 300                 


Asn Ser Arg Leu Pro Gln Pro Pro Met Pro Ser Asn Phe Pro Glu Pro 
305                 310                 315                 320 


Pro Ser Phe Ser Pro Val Val Asp Ser Leu Phe Ser Ser Gly Thr Leu 
                325                 330                 335     


Gly Pro Glu Val Pro Pro Ala Ser Ser Ala Met Thr His Leu Ser Gly 
            340                 345                 350         


His Ser Arg Leu Gln Ala Arg Asn Ser Cys Pro Gly Pro Leu Asp Ser 
        355                 360                 365             


Ser Ala Phe Leu Ser Ser Asp Phe Leu Leu Pro Glu Asp Pro Lys Pro 
    370                 375                 380                 


Arg Leu Pro Pro Pro Pro Val Pro Pro Pro Leu Leu His Tyr Pro Pro 
385                 390                 395                 400 


Pro Ala Lys Val Pro Gly Leu Glu Pro Cys Pro Pro Pro Pro Phe Pro 
                405                 410                 415     


Pro Met Ala Pro Pro Thr Ala Leu Leu Gln Glu Glu Pro Leu Phe Ser 
            420                 425                 430         


Pro Arg Phe Pro Phe Pro Thr Val Pro Pro Ala Pro Gly Val Ser Pro 
        435                 440                 445             


Leu Pro Ala Pro Ala Ala Phe Pro Pro Thr Pro Gln Ser Val Pro Ser 
    450                 455                 460                 


Pro Ala Pro Thr Pro Phe Pro Ile Glu Leu Leu Pro Leu Gly Tyr Ser 
465                 470                 475                 480 


Glu Pro Ala Phe Gly Pro Cys Phe Ser Met Pro Arg Gly Lys Pro Pro 
                485                 490                 495     


Ala Pro Ser Pro Arg Gly Gln Lys Ala Ser Pro Pro Thr Leu Ala Pro 
            500                 505                 510         


Ala Thr Ala Ser Pro Pro Thr Thr Ala Gly Ser Asn Asn Pro Cys Leu 
        515                 520                 525             


Thr Gln Leu Leu Thr Ala Ala Lys Pro Glu Gln Ala Leu Glu Pro Pro 
    530                 535                 540                 


Leu Val Ser Ser Thr Leu Leu Arg Ser Pro Gly Ser Pro Gln Glu Thr 
545                 550                 555                 560 


Val Pro Glu Phe Pro Cys Thr Phe Leu Pro Pro Thr Pro Ala Pro Thr 
                565                 570                 575     


Pro Pro Arg Pro Pro Pro Gly Pro Ala Thr Leu Ala Pro Ser Arg Pro 
            580                 585                 590         


Leu Leu Val Pro Lys Ala Glu Arg Leu Ser Pro Pro Ala Pro Ser Gly 
        595                 600                 605             


Ser Glu Arg Arg Leu Ser Gly Asp Leu Ser Ser Met Pro Gly Pro Gly 
    610                 615                 620                 


Thr Leu Ser Val Arg Val Ser Pro Pro Gln Pro Ile Leu Ser Arg Gly 
625                 630                 635                 640 


Arg Pro Asp Ser Asn Lys Thr Glu Asn Arg Arg Ile Thr His Ile Ser 
                645                 650                 655     


Ala Glu Gln Lys Arg Arg Phe Asn Ile Lys Leu Gly Phe Asp Thr Leu 
            660                 665                 670         


His Gly Leu Val Ser Thr Leu Ser Ala Gln Pro Ser Leu Lys Val Ser 
        675                 680                 685             


Lys Ala Thr Thr Leu Gln Lys Thr Ala Glu Tyr Ile Leu Met Leu Gln 
    690                 695                 700                 


Gln Glu Arg Ala Gly Leu Gln Glu Glu Ala Gln Gln Leu Arg Asp Glu 
705                 710                 715                 720 


Ile Glu Glu Leu Asn Ala Ala Ile Asn Leu Cys Gln Gln Gln Leu Pro 
                725                 730                 735     


Ala Thr Gly Val Pro Ile Thr His Gln Arg Phe Asp Gln Met Arg Asp 
            740                 745                 750         


Met Phe Asp Asp Tyr Val Arg Thr Arg Thr Leu His Asn Trp Lys Phe 
        755                 760                 765             


Trp Val Phe Ser Ile Leu Ile Arg Pro Leu Phe Glu Ser Phe Asn Gly 
    770                 775                 780                 


Met Val Ser Thr Ala Ser Val His Thr Leu Arg Gln Thr Ser Leu Ala 
785                 790                 795                 800 


Trp Leu Asp Gln Tyr Cys Ser Leu Pro Ala Leu Arg Pro Thr Val Leu 
                805                 810                 815     


Asn Ser Leu Arg Gln Leu Gly Thr Ser Thr Ser Ile Leu Thr Asp Pro 
            820                 825                 830         


Gly Arg Ile Pro Glu Gln Ala Thr Arg Ala Val Thr Glu Gly Thr Leu 
        835                 840                 845             


Gly Lys Pro Leu 
    850         


<210>  8756
<211>  575
<212>  PRT
<213>  Homo Sapiens

<400>  8756

Met Ala Gly Ala Leu Ala Gly Leu Ala Ala Gly Leu Gln Val Pro Arg 
1               5                   10                  15      


Val Ala Pro Ser Pro Asp Ser Asp Ser Asp Thr Asp Ser Glu Asp Pro 
            20                  25                  30          


Ser Leu Arg Arg Ser Ala Gly Gly Leu Leu Arg Ser Gln Val Ile His 
        35                  40                  45              


Ser Gly His Phe Met Val Ser Ser Pro His Ser Asp Ser Leu Pro Arg 
    50                  55                  60                  


Arg Arg Asp Gln Glu Gly Ser Val Gly Pro Ser Asp Phe Gly Pro Arg 
65                  70                  75                  80  


Ser Ile Asp Pro Thr Leu Thr Arg Leu Phe Glu Cys Leu Ser Leu Ala 
                85                  90                  95      


Tyr Ser Gly Lys Leu Val Ser Pro Lys Trp Lys Asn Phe Lys Gly Leu 
            100                 105                 110         


Lys Leu Leu Cys Arg Asp Lys Ile Arg Leu Asn Asn Ala Ile Trp Arg 
        115                 120                 125             


Ala Trp Tyr Ile Gln Tyr Val Lys Arg Arg Lys Ser Pro Val Cys Gly 
    130                 135                 140                 


Phe Val Thr Pro Leu Gln Gly Pro Glu Ala Asp Ala His Arg Lys Pro 
145                 150                 155                 160 


Glu Ala Val Val Leu Glu Gly Asn Tyr Trp Lys Arg Arg Ile Glu Val 
                165                 170                 175     


Val Met Arg Glu Tyr His Lys Trp Arg Ile Tyr Tyr Lys Lys Arg Leu 
            180                 185                 190         


Arg Lys Pro Ser Arg Glu Asp Asp Leu Leu Ala Pro Lys Gln Ala Glu 
        195                 200                 205             


Gly Arg Trp Pro Pro Pro Glu Gln Trp Cys Lys Gln Leu Phe Ser Ser 
    210                 215                 220                 


Val Val Pro Val Leu Leu Gly Asp Pro Glu Glu Glu Pro Gly Gly Arg 
225                 230                 235                 240 


Gln Leu Leu Asp Leu Asn Cys Phe Leu Ser Asp Ile Ser Asp Thr Leu 
                245                 250                 255     


Phe Thr Met Thr Gln Ser Gly Pro Ser Pro Leu Gln Leu Pro Pro Glu 
            260                 265                 270         


Asp Ala Tyr Val Gly Asn Ala Asp Met Ile Gln Pro Asp Leu Thr Pro 
        275                 280                 285             


Leu Gln Pro Ser Leu Asp Asp Phe Met Asp Ile Ser Asp Phe Phe Thr 
    290                 295                 300                 


Asn Ser Arg Leu Pro Gln Pro Pro Met Pro Ser Asn Phe Pro Glu Pro 
305                 310                 315                 320 


Pro Ser Phe Ser Pro Val Val Asp Ser Leu Phe Ser Ser Gly Thr Leu 
                325                 330                 335     


Gly Pro Glu Val Pro Pro Ala Ser Ser Ala Met Thr His Leu Ser Gly 
            340                 345                 350         


His Ser Arg Leu Gln Ala Arg Asn Ser Cys Pro Gly Pro Leu Asp Ser 
        355                 360                 365             


Ser Ala Phe Leu Ser Ser Asp Phe Leu Leu Pro Glu Asp Pro Lys Pro 
    370                 375                 380                 


Arg Leu Pro Pro Pro Pro Val Pro Pro Pro Leu Leu His Tyr Pro Pro 
385                 390                 395                 400 


Pro Ala Lys Val Pro Gly Leu Glu Pro Cys Pro Pro Pro Pro Phe Pro 
                405                 410                 415     


Pro Met Ala Pro Pro Thr Ala Leu Leu Gln Glu Glu Pro Leu Phe Ser 
            420                 425                 430         


Pro Arg Phe Pro Phe Pro Thr Val Pro Pro Ala Pro Gly Val Ser Pro 
        435                 440                 445             


Leu Pro Ala Pro Ala Ala Phe Pro Pro Thr Pro Gln Ser Val Pro Ser 
    450                 455                 460                 


Pro Ala Pro Thr Pro Phe Pro Ile Glu Leu Leu Pro Leu Gly Tyr Ser 
465                 470                 475                 480 


Glu Pro Ala Phe Gly Pro Cys Phe Ser Met Pro Arg Gly Lys Pro Pro 
                485                 490                 495     


Ala Pro Ser Pro Arg Gly Gln Lys Ala Ser Pro Pro Thr Leu Ala Pro 
            500                 505                 510         


Ala Thr Ala Ser Pro Pro Thr Thr Ala Gly Ser Asn Asn Pro Cys Leu 
        515                 520                 525             


Thr Gln Leu Leu Thr Ala Ala Lys Pro Glu Gln Ala Leu Glu Pro Pro 
    530                 535                 540                 


Leu Val Ser Ser Thr Leu Leu Arg Ser Pro Gly Ser Pro Ala Val Asn 
545                 550                 555                 560 


Gly Gly Cys Gln Gly Thr Ser Ala Pro Cys Gln Ala Leu Gly Leu 
                565                 570                 575 


<210>  8757
<211>  831
<212>  PRT
<213>  Homo Sapiens

<400>  8757

Met Ala Gly Ala Leu Ala Gly Leu Ala Ala Gly Leu Gln Val Pro Arg 
1               5                   10                  15      


Val Ala Pro Ser Pro Asp Ser Asp Ser Asp Thr Asp Ser Glu Asp Pro 
            20                  25                  30          


Ser Leu Arg Arg Ser Ala Gly Gly Leu Leu Arg Ser Gln Val Ile His 
        35                  40                  45              


Ser Gly His Phe Met Val Ser Ser Pro His Ser Asp Ser Leu Pro Arg 
    50                  55                  60                  


Arg Arg Asp Gln Glu Gly Ser Val Gly Pro Ser Asp Phe Gly Pro Arg 
65                  70                  75                  80  


Ser Ile Asp Pro Thr Leu Thr Arg Leu Phe Glu Cys Leu Ser Leu Ala 
                85                  90                  95      


Tyr Ser Gly Lys Leu Val Ser Pro Lys Trp Lys Asn Phe Lys Gly Leu 
            100                 105                 110         


Lys Leu Leu Cys Arg Asp Lys Ile Arg Leu Asn Asn Ala Ile Trp Arg 
        115                 120                 125             


Ala Trp Tyr Ile Gln Tyr Val Lys Arg Arg Lys Ser Pro Val Cys Gly 
    130                 135                 140                 


Phe Val Thr Pro Leu Gln Gly Pro Glu Ala Asp Ala His Arg Lys Pro 
145                 150                 155                 160 


Glu Ala Val Val Leu Glu Gly Asn Tyr Trp Lys Arg Arg Ile Glu Val 
                165                 170                 175     


Val Met Arg Glu Tyr His Lys Trp Arg Ile Tyr Tyr Lys Lys Arg Leu 
            180                 185                 190         


Arg Lys Pro Ser Arg Glu Asp Asp Leu Leu Ala Pro Lys Gln Ala Glu 
        195                 200                 205             


Gly Arg Trp Pro Pro Pro Glu Gln Trp Cys Lys Gln Leu Phe Ser Ser 
    210                 215                 220                 


Val Val Pro Val Leu Leu Gly Asp Pro Glu Glu Glu Pro Gly Gly Arg 
225                 230                 235                 240 


Gln Leu Leu Asp Leu Asn Cys Phe Leu Ser Asp Ile Ser Asp Thr Leu 
                245                 250                 255     


Phe Thr Met Thr Gln Ser Gly Pro Ser Pro Leu Gln Leu Pro Pro Glu 
            260                 265                 270         


Asp Ala Tyr Val Gly Asn Ala Asp Met Ile Gln Pro Asp Leu Thr Pro 
        275                 280                 285             


Leu Gln Pro Ser Leu Asp Asp Phe Met Asp Ile Ser Asp Phe Phe Thr 
    290                 295                 300                 


Asn Ser Arg Leu Pro Gln Pro Pro Met Pro Ser Asn Phe Pro Glu Pro 
305                 310                 315                 320 


Pro Ser Phe Ser Pro Val Val Asp Ser Leu Phe Ser Ser Gly Thr Leu 
                325                 330                 335     


Gly Pro Glu Val Pro Pro Ala Ser Ser Ala Met Thr His Leu Ser Gly 
            340                 345                 350         


His Ser Arg Leu Gln Ala Arg Asn Ser Cys Pro Gly Pro Leu Asp Ser 
        355                 360                 365             


Ser Ala Phe Leu Ser Ser Asp Phe Leu Leu Pro Glu Asp Pro Lys Pro 
    370                 375                 380                 


Arg Leu Pro Pro Pro Pro Val Pro Pro Pro Leu Leu His Tyr Pro Pro 
385                 390                 395                 400 


Pro Ala Lys Val Pro Gly Leu Glu Pro Cys Pro Pro Pro Pro Phe Pro 
                405                 410                 415     


Pro Met Ala Pro Pro Thr Ala Leu Leu Gln Glu Glu Pro Leu Phe Ser 
            420                 425                 430         


Pro Arg Phe Pro Phe Pro Thr Val Pro Pro Ala Pro Gly Val Ser Pro 
        435                 440                 445             


Leu Pro Ala Pro Ala Ala Phe Pro Pro Thr Pro Gln Ser Val Pro Ser 
    450                 455                 460                 


Pro Ala Pro Thr Pro Phe Pro Ile Glu Leu Leu Pro Leu Gly Tyr Ser 
465                 470                 475                 480 


Glu Pro Ala Phe Gly Pro Cys Phe Ser Met Pro Arg Gly Lys Pro Pro 
                485                 490                 495     


Ala Pro Ser Pro Arg Gly Gln Lys Ala Ser Pro Pro Thr Leu Ala Pro 
            500                 505                 510         


Ala Thr Ala Ser Pro Pro Thr Thr Ala Gly Ser Asn Asn Pro Cys Leu 
        515                 520                 525             


Thr Gln Leu Leu Thr Ala Ala Lys Pro Glu Gln Ala Leu Glu Pro Pro 
    530                 535                 540                 


Leu Val Ser Ser Thr Leu Leu Arg Ser Pro Gly Ser Pro Gln Glu Thr 
545                 550                 555                 560 


Val Pro Glu Phe Pro Cys Thr Phe Leu Pro Pro Thr Pro Ala Pro Thr 
                565                 570                 575     


Pro Pro Arg Pro Pro Pro Gly Pro Ala Thr Leu Ala Pro Ser Arg Pro 
            580                 585                 590         


Leu Leu Val Pro Lys Ala Glu Arg Leu Ser Pro Pro Ala Pro Ser Gly 
        595                 600                 605             


Ser Glu Arg Arg Leu Ser Gly Asp Leu Ser Ser Met Pro Gly Pro Gly 
    610                 615                 620                 


Thr Leu Ser Val Arg Val Ser Pro Pro Gln Pro Ile Leu Ser Arg Gly 
625                 630                 635                 640 


Arg Pro Asp Ser Asn Lys Asn Arg Arg Ile Thr His Ile Ser Ala Glu 
                645                 650                 655     


Gln Lys Arg Arg Phe Asn Ile Lys Leu Gly Phe Asp Thr Leu His Gly 
            660                 665                 670         


Leu Val Ser Thr Leu Ser Ala Gln Pro Ser Leu Lys Glu Arg Ala Gly 
        675                 680                 685             


Leu Gln Glu Glu Ala Gln Gln Leu Arg Asp Glu Ile Glu Glu Leu Asn 
    690                 695                 700                 


Ala Ala Ile Asn Leu Cys Gln Gln Gln Leu Pro Ala Thr Gly Val Pro 
705                 710                 715                 720 


Ile Thr His Gln Arg Phe Asp Gln Met Arg Asp Met Phe Asp Asp Tyr 
                725                 730                 735     


Val Arg Thr Arg Thr Leu His Asn Trp Lys Phe Trp Val Phe Ser Ile 
            740                 745                 750         


Leu Ile Arg Pro Leu Phe Glu Ser Phe Asn Gly Met Val Ser Thr Ala 
        755                 760                 765             


Ser Val His Thr Leu Arg Gln Thr Ser Leu Ala Trp Leu Asp Gln Tyr 
    770                 775                 780                 


Cys Ser Leu Pro Ala Leu Arg Pro Thr Val Leu Asn Ser Leu Arg Gln 
785                 790                 795                 800 


Leu Gly Thr Ser Thr Ser Ile Leu Thr Asp Pro Gly Arg Ile Pro Glu 
                805                 810                 815     


Gln Ala Thr Arg Ala Val Thr Glu Gly Thr Leu Gly Lys Pro Leu 
            820                 825                 830     


<210>  8758
<211>  833
<212>  PRT
<213>  Homo Sapiens

<400>  8758

Met Ala Gly Ala Leu Ala Gly Leu Ala Ala Gly Leu Gln Val Pro Arg 
1               5                   10                  15      


Val Ala Pro Ser Pro Asp Ser Asp Ser Asp Thr Asp Ser Glu Asp Pro 
            20                  25                  30          


Ser Leu Arg Arg Ser Ala Gly Gly Leu Leu Arg Ser Gln Val Ile His 
        35                  40                  45              


Ser Gly His Phe Met Val Ser Ser Pro His Ser Asp Ser Leu Pro Arg 
    50                  55                  60                  


Arg Arg Asp Gln Glu Gly Ser Val Gly Pro Ser Asp Phe Gly Pro Arg 
65                  70                  75                  80  


Ser Ile Asp Pro Thr Leu Thr Arg Leu Phe Glu Cys Leu Ser Leu Ala 
                85                  90                  95      


Tyr Ser Gly Lys Leu Val Ser Pro Lys Trp Lys Asn Phe Lys Gly Leu 
            100                 105                 110         


Lys Leu Leu Cys Arg Asp Lys Ile Arg Leu Asn Asn Ala Ile Trp Arg 
        115                 120                 125             


Ala Trp Tyr Ile Gln Tyr Val Lys Arg Arg Lys Ser Pro Val Cys Gly 
    130                 135                 140                 


Phe Val Thr Pro Leu Gln Gly Pro Glu Ala Asp Ala His Arg Lys Pro 
145                 150                 155                 160 


Glu Ala Val Val Leu Glu Gly Asn Tyr Trp Lys Arg Arg Ile Glu Val 
                165                 170                 175     


Val Met Arg Glu Tyr His Lys Trp Arg Ile Tyr Tyr Lys Lys Arg Leu 
            180                 185                 190         


Arg Lys Pro Ser Arg Glu Asp Asp Leu Leu Ala Pro Lys Gln Ala Glu 
        195                 200                 205             


Gly Arg Trp Pro Pro Pro Glu Gln Trp Cys Lys Gln Leu Phe Ser Ser 
    210                 215                 220                 


Val Val Pro Val Leu Leu Gly Asp Pro Glu Glu Glu Pro Gly Gly Arg 
225                 230                 235                 240 


Gln Leu Leu Asp Leu Asn Cys Phe Leu Ser Asp Ile Ser Asp Thr Leu 
                245                 250                 255     


Phe Thr Met Thr Gln Ser Gly Pro Ser Pro Leu Gln Leu Pro Pro Glu 
            260                 265                 270         


Asp Ala Tyr Val Gly Asn Ala Asp Met Ile Gln Pro Asp Leu Thr Pro 
        275                 280                 285             


Leu Gln Pro Ser Leu Asp Asp Phe Met Asp Ile Ser Asp Phe Phe Thr 
    290                 295                 300                 


Asn Ser Arg Leu Pro Gln Pro Pro Met Pro Ser Asn Phe Pro Glu Pro 
305                 310                 315                 320 


Pro Ser Phe Ser Pro Val Val Asp Ser Leu Phe Ser Ser Gly Thr Leu 
                325                 330                 335     


Gly Pro Glu Val Pro Pro Ala Ser Ser Ala Met Thr His Leu Ser Gly 
            340                 345                 350         


His Ser Arg Leu Gln Ala Arg Asn Ser Cys Pro Gly Pro Leu Asp Ser 
        355                 360                 365             


Ser Ala Phe Leu Ser Ser Asp Phe Leu Leu Pro Glu Asp Pro Lys Pro 
    370                 375                 380                 


Arg Leu Pro Pro Pro Pro Val Pro Pro Pro Leu Leu His Tyr Pro Pro 
385                 390                 395                 400 


Pro Ala Lys Val Pro Gly Leu Glu Pro Cys Pro Pro Pro Pro Phe Pro 
                405                 410                 415     


Pro Met Ala Pro Pro Thr Ala Leu Leu Gln Glu Glu Pro Leu Phe Ser 
            420                 425                 430         


Pro Arg Phe Pro Phe Pro Thr Val Pro Pro Ala Pro Gly Val Ser Pro 
        435                 440                 445             


Leu Pro Ala Pro Ala Ala Phe Pro Pro Thr Pro Gln Ser Val Pro Ser 
    450                 455                 460                 


Pro Ala Pro Thr Pro Phe Pro Ile Glu Leu Leu Pro Leu Gly Tyr Ser 
465                 470                 475                 480 


Glu Pro Ala Phe Gly Pro Cys Phe Ser Met Pro Arg Gly Lys Pro Pro 
                485                 490                 495     


Ala Pro Ser Pro Arg Gly Gln Lys Ala Ser Pro Pro Thr Leu Ala Pro 
            500                 505                 510         


Ala Thr Ala Ser Pro Pro Thr Thr Ala Gly Ser Asn Asn Pro Cys Leu 
        515                 520                 525             


Thr Gln Leu Leu Thr Ala Ala Lys Pro Glu Gln Ala Leu Glu Pro Pro 
    530                 535                 540                 


Leu Val Ser Ser Thr Leu Leu Arg Ser Pro Gly Ser Pro Gln Glu Thr 
545                 550                 555                 560 


Val Pro Glu Phe Pro Cys Thr Phe Leu Pro Pro Thr Pro Ala Pro Thr 
                565                 570                 575     


Pro Pro Arg Pro Pro Pro Gly Pro Ala Thr Leu Ala Pro Ser Arg Pro 
            580                 585                 590         


Leu Leu Val Pro Lys Ala Glu Arg Leu Ser Pro Pro Ala Pro Ser Gly 
        595                 600                 605             


Ser Glu Arg Arg Leu Ser Gly Asp Leu Ser Ser Met Pro Gly Pro Gly 
    610                 615                 620                 


Thr Leu Ser Val Arg Val Ser Pro Pro Gln Pro Ile Leu Ser Arg Gly 
625                 630                 635                 640 


Arg Pro Asp Ser Asn Lys Thr Glu Asn Arg Arg Ile Thr His Ile Ser 
                645                 650                 655     


Ala Glu Gln Lys Arg Arg Phe Asn Ile Lys Leu Gly Phe Asp Thr Leu 
            660                 665                 670         


His Gly Leu Val Ser Thr Leu Ser Ala Gln Pro Ser Leu Lys Glu Arg 
        675                 680                 685             


Ala Gly Leu Gln Glu Glu Ala Gln Gln Leu Arg Asp Glu Ile Glu Glu 
    690                 695                 700                 


Leu Asn Ala Ala Ile Asn Leu Cys Gln Gln Gln Leu Pro Ala Thr Gly 
705                 710                 715                 720 


Val Pro Ile Thr His Gln Arg Phe Asp Gln Met Arg Asp Met Phe Asp 
                725                 730                 735     


Asp Tyr Val Arg Thr Arg Thr Leu His Asn Trp Lys Phe Trp Val Phe 
            740                 745                 750         


Ser Ile Leu Ile Arg Pro Leu Phe Glu Ser Phe Asn Gly Met Val Ser 
        755                 760                 765             


Thr Ala Ser Val His Thr Leu Arg Gln Thr Ser Leu Ala Trp Leu Asp 
    770                 775                 780                 


Gln Tyr Cys Ser Leu Pro Ala Leu Arg Pro Thr Val Leu Asn Ser Leu 
785                 790                 795                 800 


Arg Gln Leu Gly Thr Ser Thr Ser Ile Leu Thr Asp Pro Gly Arg Ile 
                805                 810                 815     


Pro Glu Gln Ala Thr Arg Ala Val Thr Glu Gly Thr Leu Gly Lys Pro 
            820                 825                 830         


Leu 
    


<210>  8759
<211>  850
<212>  PRT
<213>  Homo Sapiens

<400>  8759

Met Ala Gly Ala Leu Ala Gly Leu Ala Ala Gly Leu Gln Val Pro Arg 
1               5                   10                  15      


Val Ala Pro Ser Pro Asp Ser Asp Ser Asp Thr Asp Ser Glu Asp Pro 
            20                  25                  30          


Ser Leu Arg Arg Ser Ala Gly Gly Leu Leu Arg Ser Gln Val Ile His 
        35                  40                  45              


Ser Gly His Phe Met Val Ser Ser Pro His Ser Asp Ser Leu Pro Arg 
    50                  55                  60                  


Arg Arg Asp Gln Glu Gly Ser Val Gly Pro Ser Asp Phe Gly Pro Arg 
65                  70                  75                  80  


Ser Ile Asp Pro Thr Leu Thr Arg Leu Phe Glu Cys Leu Ser Leu Ala 
                85                  90                  95      


Tyr Ser Gly Lys Leu Val Ser Pro Lys Trp Lys Asn Phe Lys Gly Leu 
            100                 105                 110         


Lys Leu Leu Cys Arg Asp Lys Ile Arg Leu Asn Asn Ala Ile Trp Arg 
        115                 120                 125             


Ala Trp Tyr Ile Gln Tyr Val Lys Arg Arg Lys Ser Pro Val Cys Gly 
    130                 135                 140                 


Phe Val Thr Pro Leu Gln Gly Pro Glu Ala Asp Ala His Arg Lys Pro 
145                 150                 155                 160 


Glu Ala Val Val Leu Glu Gly Asn Tyr Trp Lys Arg Arg Ile Glu Val 
                165                 170                 175     


Val Met Arg Glu Tyr His Lys Trp Arg Ile Tyr Tyr Lys Lys Arg Leu 
            180                 185                 190         


Arg Lys Pro Ser Arg Glu Asp Asp Leu Leu Ala Pro Lys Gln Ala Glu 
        195                 200                 205             


Gly Arg Trp Pro Pro Pro Glu Gln Trp Cys Lys Gln Leu Phe Ser Ser 
    210                 215                 220                 


Val Val Pro Val Leu Leu Gly Asp Pro Glu Glu Glu Pro Gly Gly Arg 
225                 230                 235                 240 


Gln Leu Leu Asp Leu Asn Cys Phe Leu Ser Asp Ile Ser Asp Thr Leu 
                245                 250                 255     


Phe Thr Met Thr Gln Ser Gly Pro Ser Pro Leu Gln Leu Pro Pro Glu 
            260                 265                 270         


Asp Ala Tyr Val Gly Asn Ala Asp Met Ile Gln Pro Asp Leu Thr Pro 
        275                 280                 285             


Leu Gln Pro Ser Leu Asp Asp Phe Met Asp Ile Ser Asp Phe Phe Thr 
    290                 295                 300                 


Asn Ser Arg Leu Pro Gln Pro Pro Met Pro Ser Asn Phe Pro Glu Pro 
305                 310                 315                 320 


Pro Ser Phe Ser Pro Val Val Asp Ser Leu Phe Ser Ser Gly Thr Leu 
                325                 330                 335     


Gly Pro Glu Val Pro Pro Ala Ser Ser Ala Met Thr His Leu Ser Gly 
            340                 345                 350         


His Ser Arg Leu Gln Ala Arg Asn Ser Cys Pro Gly Pro Leu Asp Ser 
        355                 360                 365             


Ser Ala Phe Leu Ser Ser Asp Phe Leu Leu Pro Glu Asp Pro Lys Pro 
    370                 375                 380                 


Arg Leu Pro Pro Pro Pro Val Pro Pro Pro Leu Leu His Tyr Pro Pro 
385                 390                 395                 400 


Pro Ala Lys Val Pro Gly Leu Glu Pro Cys Pro Pro Pro Pro Phe Pro 
                405                 410                 415     


Pro Met Ala Pro Pro Thr Ala Leu Leu Gln Glu Glu Pro Leu Phe Ser 
            420                 425                 430         


Pro Arg Phe Pro Phe Pro Thr Val Pro Pro Ala Pro Gly Val Ser Pro 
        435                 440                 445             


Leu Pro Ala Pro Ala Ala Phe Pro Pro Thr Pro Gln Ser Val Pro Ser 
    450                 455                 460                 


Pro Ala Pro Thr Pro Phe Pro Ile Glu Leu Leu Pro Leu Gly Tyr Ser 
465                 470                 475                 480 


Glu Pro Ala Phe Gly Pro Cys Phe Ser Met Pro Arg Gly Lys Pro Pro 
                485                 490                 495     


Ala Pro Ser Pro Arg Gly Gln Lys Ala Ser Pro Pro Thr Leu Ala Pro 
            500                 505                 510         


Ala Thr Ala Ser Pro Pro Thr Thr Ala Gly Ser Asn Asn Pro Cys Leu 
        515                 520                 525             


Thr Gln Leu Leu Thr Ala Ala Lys Pro Glu Gln Ala Leu Glu Pro Pro 
    530                 535                 540                 


Leu Val Ser Ser Thr Leu Leu Arg Ser Pro Gly Ser Pro Gln Glu Thr 
545                 550                 555                 560 


Val Pro Glu Phe Pro Cys Thr Phe Leu Pro Pro Thr Pro Ala Pro Thr 
                565                 570                 575     


Pro Pro Arg Pro Pro Pro Gly Pro Ala Thr Leu Ala Pro Ser Arg Pro 
            580                 585                 590         


Leu Leu Val Pro Lys Ala Glu Arg Leu Ser Pro Pro Ala Pro Ser Gly 
        595                 600                 605             


Ser Glu Arg Arg Leu Ser Gly Asp Leu Ser Ser Met Pro Gly Pro Gly 
    610                 615                 620                 


Thr Leu Ser Val Arg Val Ser Pro Pro Gln Pro Ile Leu Ser Arg Gly 
625                 630                 635                 640 


Arg Pro Asp Ser Asn Lys Asn Arg Arg Ile Thr His Ile Ser Ala Glu 
                645                 650                 655     


Gln Lys Arg Arg Phe Asn Ile Lys Leu Gly Phe Asp Thr Leu His Gly 
            660                 665                 670         


Leu Val Ser Thr Leu Ser Ala Gln Pro Ser Leu Lys Val Ser Lys Ala 
        675                 680                 685             


Thr Thr Leu Gln Lys Thr Ala Glu Tyr Ile Leu Met Leu Gln Gln Glu 
    690                 695                 700                 


Arg Ala Gly Leu Gln Glu Glu Ala Gln Gln Leu Arg Asp Glu Ile Glu 
705                 710                 715                 720 


Glu Leu Asn Ala Ala Ile Asn Leu Cys Gln Gln Gln Leu Pro Ala Thr 
                725                 730                 735     


Gly Val Pro Ile Thr His Gln Arg Phe Asp Gln Met Arg Asp Met Phe 
            740                 745                 750         


Asp Asp Tyr Val Arg Thr Arg Thr Leu His Asn Trp Lys Phe Trp Val 
        755                 760                 765             


Phe Ser Ile Leu Ile Arg Pro Leu Phe Glu Ser Phe Asn Gly Met Val 
    770                 775                 780                 


Ser Thr Ala Ser Val His Thr Leu Arg Gln Thr Ser Leu Ala Trp Leu 
785                 790                 795                 800 


Asp Gln Tyr Cys Ser Leu Pro Ala Leu Arg Pro Thr Val Leu Asn Ser 
                805                 810                 815     


Leu Arg Gln Leu Gly Thr Ser Thr Ser Ile Leu Thr Asp Pro Gly Arg 
            820                 825                 830         


Ile Pro Glu Gln Ala Thr Arg Ala Val Thr Glu Gly Thr Leu Gly Lys 
        835                 840                 845             


Pro Leu 
    850 


<210>  8760
<211>  235
<212>  PRT
<213>  Homo Sapiens

<400>  8760

Pro Lys Trp Lys Asn Phe Lys Gly Leu Lys Leu Leu Cys Arg Asp Lys 
1               5                   10                  15      


Ile Arg Leu Asn Asn Ala Ile Trp Arg Ala Trp Tyr Ile Gln Tyr Val 
            20                  25                  30          


Lys Arg Arg Lys Ser Pro Val Cys Gly Phe Val Thr Pro Leu Gln Gly 
        35                  40                  45              


Pro Glu Ala Asp Ala His Arg Lys Pro Glu Ala Val Val Leu Glu Gly 
    50                  55                  60                  


Asn Tyr Trp Lys Arg Arg Ile Glu Val Val Met Arg Glu Tyr His Lys 
65                  70                  75                  80  


Trp Arg Ile Tyr Tyr Lys Lys Arg Val Ser Gly Gly Gly Pro Gly Arg 
                85                  90                  95      


Pro Gln Ser Phe Pro Pro Ala Ala Ala Gly Tyr Arg Pro Pro Arg Lys 
            100                 105                 110         


Ile Pro Gly Lys Gly Ile Leu Thr Pro Glu Leu Ala Pro Leu Gly Pro 
        115                 120                 125             


Ser Ile Gln Ser Arg Ala Asp Ser Ala Thr Val Trp Pro Gln Arg Leu 
    130                 135                 140                 


Leu Ala Ala Ser Leu Pro Arg Gly Arg Leu Arg Lys Pro Ser Arg Glu 
145                 150                 155                 160 


Asp Asp Leu Leu Ala Pro Lys Gln Ala Glu Gly Arg Trp Pro Pro Pro 
                165                 170                 175     


Glu Gln Trp Cys Lys Gln Leu Phe Ser Ser Val Val Pro Val Leu Leu 
            180                 185                 190         


Gly Asp Pro Glu Glu Glu Pro Gly Gly Arg Gln Leu Leu Asp Leu Asn 
        195                 200                 205             


Cys Phe Leu Ser Asp Ile Ser Asp Thr Leu Phe Thr Met Thr Gln Ser 
    210                 215                 220                 


Gly Pro Ser Pro Leu Gln Leu Pro Pro Glu Asp 
225                 230                 235 


<210>  8761
<211>  469
<212>  PRT
<213>  Homo Sapiens

<400>  8761

Met His Ser Phe Pro Pro Leu Leu Leu Leu Leu Phe Trp Gly Val Val 
1               5                   10                  15      


Ser His Ser Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp 
            20                  25                  30          


Leu Val Gln Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly 
        35                  40                  45              


Arg Gln Val Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu 
    50                  55                  60                  


Lys Gln Met Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp 
65                  70                  75                  80  


Ala Glu Thr Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp 
                85                  90                  95      


Val Ala Gln Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr 
            100                 105                 110         


His Leu Thr Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala 
        115                 120                 125             


Asp Val Asp His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val 
    130                 135                 140                 


Thr Pro Leu Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met 
145                 150                 155                 160 


Ile Ser Phe Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly 
                165                 170                 175     


Pro Gly Gly Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly 
            180                 185                 190         


Gly Asp Ala His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg 
        195                 200                 205             


Glu Tyr Asn Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu 
    210                 215                 220                 


Gly Leu Ser His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr 
225                 230                 235                 240 


Thr Phe Ser Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile 
                245                 250                 255     


Gln Ala Ile Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro 
            260                 265                 270         


Gln Thr Pro Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr 
        275                 280                 285             


Thr Ile Arg Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg 
    290                 295                 300                 


Thr Asn Pro Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe 
305                 310                 315                 320 


Trp Pro Gln Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp 
                325                 330                 335     


Arg Asp Glu Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln 
            340                 345                 350         


Gly Gln Asn Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe 
        355                 360                 365             


Gly Phe Pro Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu 
    370                 375                 380                 


Asn Thr Gly Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr 
385                 390                 395                 400 


Asp Glu Tyr Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala 
                405                 410                 415     


His Asp Phe Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys 
            420                 425                 430         


Asp Gly Phe Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp 
        435                 440                 445             


Pro Lys Thr Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe 
    450                 455                 460                 


Asn Cys Arg Lys Asn 
465                 


<210>  8762
<211>  476
<212>  PRT
<213>  Homo Sapiens

<400>  8762

Met Met His Leu Ala Phe Leu Val Leu Leu Cys Leu Pro Val Cys Ser 
1               5                   10                  15      


Ala Tyr Pro Leu Ser Gly Ala Ala Lys Glu Glu Asp Ser Asn Lys Asp 
            20                  25                  30          


Leu Ala Gln Gln Tyr Leu Glu Lys Tyr Tyr Asn Leu Glu Lys Asp Val 
        35                  40                  45              


Lys Gln Phe Arg Arg Lys Asp Ser Asn Leu Ile Val Lys Lys Ile Gln 
    50                  55                  60                  


Gly Met Gln Lys Phe Leu Gly Leu Glu Val Thr Gly Lys Leu Asp Thr 
65                  70                  75                  80  


Asp Thr Leu Glu Val Met Arg Lys Pro Arg Cys Gly Val Pro Asp Val 
                85                  90                  95      


Gly His Phe Ser Ser Phe Pro Gly Met Pro Lys Trp Arg Lys Thr His 
            100                 105                 110         


Leu Thr Tyr Arg Ile Val Asn Tyr Thr Pro Asp Leu Pro Arg Asp Ala 
        115                 120                 125             


Val Asp Ser Ala Ile Glu Lys Ala Leu Lys Val Trp Glu Glu Val Thr 
    130                 135                 140                 


Pro Leu Thr Phe Ser Arg Leu Tyr Glu Gly Glu Ala Asp Ile Met Ile 
145                 150                 155                 160 


Ser Phe Ala Val Lys Glu His Gly Asp Phe Tyr Ser Phe Asp Gly Pro 
                165                 170                 175     


Gly His Ser Leu Ala His Ala Tyr Pro Pro Gly Pro Gly Leu Tyr Gly 
            180                 185                 190         


Asp Ile His Phe Asp Asp Asp Glu Lys Trp Thr Glu Asp Ala Ser Gly 
        195                 200                 205             


Thr Asn Leu Phe Leu Val Ala Ala His Glu Leu Gly His Ser Leu Gly 
    210                 215                 220                 


Leu Phe His Ser Ala Asn Thr Glu Ala Leu Met Tyr Pro Leu Tyr Asn 
225                 230                 235                 240 


Ser Phe Thr Glu Leu Ala Gln Phe Arg Leu Ser Gln Asp Asp Val Asn 
                245                 250                 255     


Gly Ile Gln Ser Leu Tyr Gly Pro Pro Pro Ala Ser Thr Glu Glu Pro 
            260                 265                 270         


Leu Val Pro Thr Lys Ser Val Pro Ser Gly Ser Glu Met Pro Ala Lys 
        275                 280                 285             


Cys Asp Pro Ala Leu Ser Phe Asp Ala Ile Ser Thr Leu Arg Gly Glu 
    290                 295                 300                 


Tyr Leu Phe Phe Lys Asp Arg Tyr Phe Trp Arg Arg Ser His Trp Asn 
305                 310                 315                 320 


Pro Glu Pro Glu Phe His Leu Ile Ser Ala Phe Trp Pro Ser Leu Pro 
                325                 330                 335     


Ser Tyr Leu Asp Ala Ala Tyr Glu Val Asn Ser Arg Asp Thr Val Phe 
            340                 345                 350         


Ile Phe Lys Gly Asn Glu Phe Trp Ala Ile Arg Gly Asn Glu Val Gln 
        355                 360                 365             


Ala Gly Tyr Pro Arg Gly Ile His Thr Leu Gly Phe Pro Pro Thr Ile 
    370                 375                 380                 


Arg Lys Ile Asp Ala Ala Val Ser Asp Lys Glu Lys Lys Lys Thr Tyr 
385                 390                 395                 400 


Phe Phe Ala Ala Asp Lys Tyr Trp Arg Phe Asp Glu Asn Ser Gln Ser 
                405                 410                 415     


Met Glu Gln Gly Phe Pro Arg Leu Ile Ala Asp Asp Phe Pro Gly Val 
            420                 425                 430         


Glu Pro Lys Val Asp Ala Val Leu Gln Ala Phe Gly Phe Phe Tyr Phe 
        435                 440                 445             


Phe Ser Gly Ser Ser Gln Phe Glu Phe Asp Pro Asn Ala Arg Met Val 
    450                 455                 460                 


Thr His Ile Leu Lys Ser Asn Ser Trp Leu His Cys 
465                 470                 475     


<210>  8763
<211>  181
<212>  PRT
<213>  Homo Sapiens

<400>  8763

Met Met His Leu Ala Phe Leu Val Leu Leu Cys Leu Pro Val Cys Ser 
1               5                   10                  15      


Ala Tyr Pro Leu Ser Gly Ala Ala Lys Glu Glu Asp Ser Asn Lys Asp 
            20                  25                  30          


Leu Ala Gln Gln Tyr Leu Glu Lys Tyr Tyr Asn Leu Glu Lys Asp Val 
        35                  40                  45              


Lys Gln Phe Arg Arg Lys Asp Ser Asn Leu Ile Val Lys Lys Ile Gln 
    50                  55                  60                  


Gly Met Gln Lys Phe Leu Gly Leu Glu Val Thr Gly Lys Leu Asp Thr 
65                  70                  75                  80  


Asp Thr Leu Glu Val Met Arg Lys Pro Arg Cys Gly Val Pro Asp Val 
                85                  90                  95      


Gly His Phe Ser Ser Phe Pro Gly Met Pro Lys Trp Arg Lys Thr His 
            100                 105                 110         


Leu Thr Tyr Arg Ile Val Asn Tyr Thr Pro Asp Leu Pro Arg Asp Ala 
        115                 120                 125             


Val Asp Ser Ala Ile Glu Lys Ala Leu Lys Val Trp Glu Glu Val Thr 
    130                 135                 140                 


Pro Leu Thr Phe Ser Arg Leu Tyr Glu Gly Glu Ala Asp Ile Met Ile 
145                 150                 155                 160 


Ser Phe Ala Val Lys Gly His Ser Leu Ala His Ala Tyr Pro Pro Gly 
                165                 170                 175     


Pro Gly Leu Tyr Gly 
            180     


<210>  8764
<211>  113
<212>  PRT
<213>  Homo Sapiens

<400>  8764

Met Ala Pro Ala Ala Trp Leu Arg Ser Ala Ala Ala Arg Ala Leu Leu 
1               5                   10                  15      


Pro Pro Met Leu Leu Leu Leu Leu Gln Pro Pro Pro Leu Leu Ala Arg 
            20                  25                  30          


Ala Leu Pro Pro Asp Ala His His Leu His Ala Glu Arg Arg Gly Pro 
        35                  40                  45              


Gln Pro Trp His Ala Ala Leu Pro Ser Ser Pro Ala Pro Ala Pro Ala 
    50                  55                  60                  


Thr Gln Glu Ala Pro Arg Pro Ala Ser Ser Leu Arg Pro Pro Arg Cys 
65                  70                  75                  80  


Gly Val Pro Asp Pro Ser Asp Gly Leu Ser Ala Arg Asn Arg Gln Lys 
                85                  90                  95      


Arg Phe Val Leu Ser Gly Gly Arg Trp Glu Lys Thr Asp Leu Thr Tyr 
            100                 105                 110         


Arg 
    


<210>  8765
<211>  488
<212>  PRT
<213>  Homo Sapiens

<400>  8765

Met Ala Pro Ala Ala Trp Leu Arg Ser Ala Ala Ala Arg Ala Leu Leu 
1               5                   10                  15      


Pro Pro Met Leu Leu Leu Leu Leu Gln Pro Pro Pro Leu Leu Ala Arg 
            20                  25                  30          


Ala Leu Pro Pro Asp Ala His His Leu His Ala Glu Arg Arg Gly Pro 
        35                  40                  45              


Gln Pro Trp His Ala Ala Leu Pro Ser Ser Pro Ala Pro Ala Pro Ala 
    50                  55                  60                  


Thr Gln Glu Ala Pro Arg Pro Ala Ser Ser Leu Arg Pro Pro Arg Cys 
65                  70                  75                  80  


Gly Val Pro Asp Pro Ser Asp Gly Leu Ser Ala Arg Asn Arg Gln Lys 
                85                  90                  95      


Arg Phe Val Leu Ser Gly Gly Arg Trp Glu Lys Thr Asp Leu Thr Tyr 
            100                 105                 110         


Arg Ile Leu Arg Phe Pro Trp Gln Leu Val Gln Glu Gln Val Arg Gln 
        115                 120                 125             


Thr Met Ala Glu Ala Leu Lys Val Trp Ser Asp Val Thr Pro Leu Thr 
    130                 135                 140                 


Phe Thr Glu Val His Glu Gly Arg Ala Asp Ile Met Ile Asp Phe Ala 
145                 150                 155                 160 


Arg Tyr Trp His Gly Asp Asp Leu Pro Phe Asp Gly Pro Gly Gly Ile 
                165                 170                 175     


Leu Ala His Ala Phe Phe Pro Lys Thr His Arg Glu Gly Asp Val His 
            180                 185                 190         


Phe Asp Tyr Asp Glu Thr Trp Thr Ile Gly Asp Asp Gln Gly Thr Asp 
        195                 200                 205             


Leu Leu Gln Val Ala Ala His Glu Phe Gly His Val Leu Gly Leu Gln 
    210                 215                 220                 


His Thr Thr Ala Ala Lys Ala Leu Met Ser Ala Phe Tyr Thr Phe Arg 
225                 230                 235                 240 


Tyr Pro Leu Ser Leu Ser Pro Asp Asp Cys Arg Gly Val Gln His Leu 
                245                 250                 255     


Tyr Gly Gln Pro Trp Pro Thr Val Thr Ser Arg Thr Pro Ala Leu Gly 
            260                 265                 270         


Pro Gln Ala Gly Ile Asp Thr Asn Glu Ile Ala Pro Leu Glu Pro Asp 
        275                 280                 285             


Ala Pro Pro Asp Ala Cys Glu Ala Ser Phe Asp Ala Val Ser Thr Ile 
    290                 295                 300                 


Arg Gly Glu Leu Phe Phe Phe Lys Ala Gly Phe Val Trp Arg Leu Arg 
305                 310                 315                 320 


Gly Gly Gln Leu Gln Pro Gly Tyr Pro Ala Leu Ala Ser Arg His Trp 
                325                 330                 335     


Gln Gly Leu Pro Ser Pro Val Asp Ala Ala Phe Glu Asp Ala Gln Gly 
            340                 345                 350         


His Ile Trp Phe Phe Gln Gly Ala Gln Tyr Trp Val Tyr Asp Gly Glu 
        355                 360                 365             


Lys Pro Val Leu Gly Pro Ala Pro Leu Thr Glu Leu Gly Leu Val Arg 
    370                 375                 380                 


Phe Pro Val His Ala Ala Leu Val Trp Gly Pro Glu Lys Asn Lys Ile 
385                 390                 395                 400 


Tyr Phe Phe Arg Gly Arg Asp Tyr Trp Arg Phe His Pro Ser Thr Arg 
                405                 410                 415     


Arg Val Asp Ser Pro Val Pro Arg Arg Ala Thr Asp Trp Arg Gly Val 
            420                 425                 430         


Pro Ser Glu Ile Asp Ala Ala Phe Gln Asp Ala Asp Gly Tyr Ala Tyr 
        435                 440                 445             


Phe Leu Arg Gly Arg Leu Tyr Trp Lys Phe Asp Pro Val Lys Val Lys 
    450                 455                 460                 


Ala Leu Glu Gly Phe Pro Arg Leu Val Gly Pro Asp Phe Phe Gly Cys 
465                 470                 475                 480 


Ala Glu Pro Ala Asn Thr Phe Leu 
                485             


<210>  8766
<211>  354
<212>  PRT
<213>  Homo Sapiens

<400>  8766

Met Ala Pro Ala Ala Trp Leu Arg Ser Ala Ala Ala Arg Ala Leu Leu 
1               5                   10                  15      


Pro Pro Met Leu Leu Leu Leu Leu Gln Pro Pro Pro Leu Leu Ala Arg 
            20                  25                  30          


Ala Leu Pro Pro Asp Ala His His Leu His Ala Glu Arg Arg Gly Pro 
        35                  40                  45              


Gln Pro Trp His Ala Ala Leu Pro Ser Ser Pro Ala Pro Ala Pro Ala 
    50                  55                  60                  


Thr Gln Glu Ala Pro Arg Pro Ala Ser Ser Leu Arg Pro Pro Arg Cys 
65                  70                  75                  80  


Gly Val Pro Asp Pro Ser Asp Gly Leu Ser Ala Arg Asn Arg Gln Lys 
                85                  90                  95      


Arg Ile Leu Arg Phe Pro Trp Gln Leu Val Gln Glu Gln Val Arg Gln 
            100                 105                 110         


Thr Met Ala Glu Ala Leu Lys Val Trp Ser Asp Val Thr Pro Leu Thr 
        115                 120                 125             


Phe Thr Glu Val His Glu Gly Arg Ala Asp Ile Met Ile Asp Phe Ala 
    130                 135                 140                 


Arg Tyr Trp His Gly Asp Asp Leu Pro Phe Asp Gly Pro Gly Gly Ile 
145                 150                 155                 160 


Leu Ala His Ala Phe Phe Pro Lys Thr His Arg Glu Gly Asp Val His 
                165                 170                 175     


Phe Asp Tyr Asp Glu Thr Trp Thr Ile Gly Asp Asp Gln Gly Thr Asp 
            180                 185                 190         


Leu Leu Gln Val Ala Ala His Glu Phe Gly His Val Leu Gly Leu Gln 
        195                 200                 205             


His Thr Thr Ala Ala Lys Ala Leu Met Ser Ala Phe Tyr Thr Phe Arg 
    210                 215                 220                 


Tyr Pro Leu Ser Leu Ser Pro Asp Asp Cys Arg Gly Val Gln His Leu 
225                 230                 235                 240 


Tyr Gly Gln Pro Trp Pro Thr Val Thr Ser Arg Thr Pro Ala Leu Gly 
                245                 250                 255     


Pro Gln Ala Gly Ile Asp Thr Asn Glu Ile Ala Pro Leu Glu Pro Asp 
            260                 265                 270         


Ala Pro Pro Asp Ala Cys Glu Ala Ser Phe Asp Ala Val Ser Thr Ile 
        275                 280                 285             


Arg Gly Glu Leu Phe Phe Phe Lys Ala Gly Phe Val Trp Arg Leu Arg 
    290                 295                 300                 


Gly Gly Gln Leu Gln Pro Gly Tyr Pro Ala Leu Ala Ser Arg His Trp 
305                 310                 315                 320 


Gln Gly Leu Pro Ser Pro Val Asp Ala Ala Phe Glu Asp Ala Gln Gly 
                325                 330                 335     


His Ile Trp Phe Phe Gln Gly Thr Thr Gly Val Ser Thr Pro Ala Pro 
            340                 345                 350         


Gly Val 
        


<210>  8767
<211>  170
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8767

Xaa Ala His Glu Phe Gly His Val Leu Gly Leu Gln His Thr Thr Ala 
1               5                   10                  15      


Ala Lys Ala Leu Met Ser Ala Phe Tyr Thr Phe Arg Tyr Pro Leu Ser 
            20                  25                  30          


Leu Ser Pro Asp Asp Cys Arg Gly Val Gln His Leu Tyr Gly Gln Pro 
        35                  40                  45              


Trp Pro Thr Val Thr Ser Arg Thr Pro Ala Leu Gly Pro Gln Ala Gly 
    50                  55                  60                  


Ile Asp Thr Asn Glu Ile Ala Pro Leu Glu Pro Asp Ala Pro Pro Asp 
65                  70                  75                  80  


Ala Cys Glu Ala Ser Phe Asp Ala Val Ser Thr Ile Arg Gly Glu Leu 
                85                  90                  95      


Phe Phe Phe Lys Ala Gly Phe Val Trp Arg Leu Arg Gly Gly Gln Leu 
            100                 105                 110         


Gln Pro Gly Tyr Pro Ala Leu Ala Ser Arg His Trp Gln Gly Leu Pro 
        115                 120                 125             


Ser Pro Val Asp Ala Ala Phe Glu Asp Ala Gln Gly His Ile Trp Phe 
    130                 135                 140                 


Phe Gln Glu Leu Gly Phe Pro Ser Ser Thr Gly Arg Asp Glu Ser Leu 
145                 150                 155                 160 


Glu His Cys Arg Cys Gln Gly Leu His Lys 
                165                 170 


<210>  8768
<211>  470
<212>  PRT
<213>  Homo Sapiens

<400>  8768

Met Lys Phe Leu Leu Ile Leu Leu Leu Gln Ala Thr Ala Ser Gly Ala 
1               5                   10                  15      


Leu Pro Leu Asn Ser Ser Thr Ser Leu Glu Lys Asn Asn Val Leu Phe 
            20                  25                  30          


Gly Glu Arg Tyr Leu Glu Lys Phe Tyr Gly Leu Glu Ile Asn Lys Leu 
        35                  40                  45              


Pro Val Thr Lys Met Lys Tyr Ser Gly Asn Leu Met Lys Glu Lys Ile 
    50                  55                  60                  


Gln Glu Met Gln His Phe Leu Gly Leu Lys Val Thr Gly Gln Leu Asp 
65                  70                  75                  80  


Thr Ser Thr Leu Glu Met Met His Ala Pro Arg Cys Gly Val Pro Asp 
                85                  90                  95      


Val His His Phe Arg Glu Met Pro Gly Gly Pro Val Trp Arg Lys His 
            100                 105                 110         


Tyr Ile Thr Tyr Arg Ile Asn Asn Tyr Thr Pro Asp Met Asn Arg Glu 
        115                 120                 125             


Asp Val Asp Tyr Ala Ile Arg Lys Ala Phe Gln Val Trp Ser Asn Val 
    130                 135                 140                 


Thr Pro Leu Lys Phe Ser Lys Ile Asn Thr Gly Met Ala Asp Ile Leu 
145                 150                 155                 160 


Val Val Phe Ala Arg Gly Ala His Gly Asp Phe His Ala Phe Asp Gly 
                165                 170                 175     


Lys Gly Gly Ile Leu Ala His Ala Phe Gly Pro Gly Ser Gly Ile Gly 
            180                 185                 190         


Gly Asp Ala His Phe Asp Glu Asp Glu Phe Trp Thr Thr His Ser Gly 
        195                 200                 205             


Gly Thr Asn Leu Phe Leu Thr Ala Val His Glu Ile Gly His Ser Leu 
    210                 215                 220                 


Gly Leu Gly His Ser Ser Asp Pro Lys Ala Val Met Phe Pro Thr Tyr 
225                 230                 235                 240 


Lys Tyr Val Asp Ile Asn Thr Phe Arg Leu Ser Ala Asp Asp Ile Arg 
                245                 250                 255     


Gly Ile Gln Ser Leu Tyr Gly Asp Pro Lys Glu Asn Gln Arg Leu Pro 
            260                 265                 270         


Asn Pro Asp Asn Ser Glu Pro Ala Leu Cys Asp Pro Asn Leu Ser Phe 
        275                 280                 285             


Asp Ala Val Thr Thr Val Gly Asn Lys Ile Phe Phe Phe Lys Asp Arg 
    290                 295                 300                 


Phe Phe Trp Leu Lys Val Ser Glu Arg Pro Lys Thr Ser Val Asn Leu 
305                 310                 315                 320 


Ile Ser Ser Leu Trp Pro Thr Leu Pro Ser Gly Ile Glu Ala Ala Tyr 
                325                 330                 335     


Glu Ile Glu Ala Arg Asn Gln Val Phe Leu Phe Lys Asp Asp Lys Tyr 
            340                 345                 350         


Trp Leu Ile Ser Asn Leu Arg Pro Glu Pro Asn Tyr Pro Lys Ser Ile 
        355                 360                 365             


His Ser Phe Gly Phe Pro Asn Phe Val Lys Lys Ile Asp Ala Ala Val 
    370                 375                 380                 


Phe Asn Pro Arg Phe Tyr Arg Thr Tyr Phe Phe Val Asp Asn Gln Tyr 
385                 390                 395                 400 


Trp Arg Tyr Asp Glu Arg Arg Gln Met Met Asp Pro Gly Tyr Pro Lys 
                405                 410                 415     


Leu Ile Thr Lys Asn Phe Gln Gly Ile Gly Pro Lys Ile Asp Ala Val 
            420                 425                 430         


Phe Tyr Ser Lys Asn Lys Tyr Tyr Tyr Phe Phe Gln Gly Ser Asn Gln 
        435                 440                 445             


Phe Glu Tyr Asp Phe Leu Leu Gln Arg Ile Thr Lys Thr Leu Lys Ser 
    450                 455                 460                 


Asn Ser Trp Phe Gly Cys 
465                 470 


<210>  8769
<211>  471
<212>  PRT
<213>  Homo Sapiens

<400>  8769

Met His Pro Gly Val Leu Ala Ala Phe Leu Phe Leu Ser Trp Thr His 
1               5                   10                  15      


Cys Arg Ala Leu Pro Leu Pro Ser Gly Gly Asp Glu Asp Asp Leu Ser 
            20                  25                  30          


Glu Glu Asp Leu Gln Phe Ala Glu Arg Tyr Leu Arg Ser Tyr Tyr His 
        35                  40                  45              


Pro Thr Asn Leu Ala Gly Ile Leu Lys Glu Asn Ala Ala Ser Ser Met 
    50                  55                  60                  


Thr Glu Arg Leu Arg Glu Met Gln Ser Phe Phe Gly Leu Glu Val Thr 
65                  70                  75                  80  


Gly Lys Leu Asp Asp Asn Thr Leu Asp Val Met Lys Lys Pro Arg Cys 
                85                  90                  95      


Gly Val Pro Asp Val Gly Glu Tyr Asn Val Phe Pro Arg Thr Leu Lys 
            100                 105                 110         


Trp Ser Lys Met Asn Leu Thr Tyr Arg Ile Val Asn Tyr Thr Pro Asp 
        115                 120                 125             


Met Thr His Ser Glu Val Glu Lys Ala Phe Lys Lys Ala Phe Lys Val 
    130                 135                 140                 


Trp Ser Asp Val Thr Pro Leu Asn Phe Thr Arg Leu His Asp Gly Ile 
145                 150                 155                 160 


Ala Asp Ile Met Ile Ser Phe Gly Ile Lys Glu His Gly Asp Phe Tyr 
                165                 170                 175     


Pro Phe Asp Gly Pro Ser Gly Leu Leu Ala His Ala Phe Pro Pro Gly 
            180                 185                 190         


Pro Asn Tyr Gly Gly Asp Ala His Phe Asp Asp Asp Glu Thr Trp Thr 
        195                 200                 205             


Ser Ser Ser Lys Gly Tyr Asn Leu Phe Leu Val Ala Ala His Glu Phe 
    210                 215                 220                 


Gly His Ser Leu Gly Leu Asp His Ser Lys Asp Pro Gly Ala Leu Met 
225                 230                 235                 240 


Phe Pro Ile Tyr Thr Tyr Thr Gly Lys Ser His Phe Met Leu Pro Asp 
                245                 250                 255     


Asp Asp Val Gln Gly Ile Gln Ser Leu Tyr Gly Pro Gly Asp Glu Asp 
            260                 265                 270         


Pro Asn Pro Lys His Pro Lys Thr Pro Asp Lys Cys Asp Pro Ser Leu 
        275                 280                 285             


Ser Leu Asp Ala Ile Thr Ser Leu Arg Gly Glu Thr Met Ile Phe Lys 
    290                 295                 300                 


Asp Arg Phe Phe Trp Arg Leu His Pro Gln Gln Val Asp Ala Glu Leu 
305                 310                 315                 320 


Phe Leu Thr Lys Ser Phe Trp Pro Glu Leu Pro Asn Arg Ile Asp Ala 
                325                 330                 335     


Ala Tyr Glu His Pro Ser His Asp Leu Ile Phe Ile Phe Arg Gly Arg 
            340                 345                 350         


Lys Phe Trp Ala Leu Asn Gly Tyr Asp Ile Leu Glu Gly Tyr Pro Lys 
        355                 360                 365             


Lys Ile Ser Glu Leu Gly Leu Pro Lys Glu Val Lys Lys Ile Ser Ala 
    370                 375                 380                 


Ala Val His Phe Glu Asp Thr Gly Lys Thr Leu Leu Phe Ser Gly Asn 
385                 390                 395                 400 


Gln Val Trp Arg Tyr Asp Asp Thr Asn His Ile Met Asp Lys Asp Tyr 
                405                 410                 415     


Pro Arg Leu Ile Glu Glu Asp Phe Pro Gly Ile Gly Asp Lys Val Asp 
            420                 425                 430         


Ala Val Tyr Glu Lys Asn Gly Tyr Ile Tyr Phe Phe Asn Gly Pro Ile 
        435                 440                 445             


Gln Phe Glu Tyr Ser Ile Trp Ser Asn Arg Ile Val Arg Val Met Pro 
    450                 455                 460                 


Ala Asn Ser Ile Leu Trp Cys 
465                 470     


<210>  8770
<211>  489
<212>  PRT
<213>  Homo Sapiens

<400>  8770

Met His Pro Gly Val Leu Ala Ala Phe Leu Phe Leu Ser Trp Thr His 
1               5                   10                  15      


Cys Arg Ala Leu Pro Leu Pro Ser Gly Gly Asp Glu Asp Asp Leu Ser 
            20                  25                  30          


Glu Glu Asp Leu Gln Phe Ala Glu Arg Tyr Leu Arg Ser Tyr Tyr His 
        35                  40                  45              


Pro Thr Asn Leu Ala Gly Ile Leu Lys Glu Asn Ala Ala Ser Ser Met 
    50                  55                  60                  


Thr Glu Arg Leu Arg Glu Met Gln Ser Phe Phe Gly Leu Glu Val Thr 
65                  70                  75                  80  


Gly Lys Leu Asp Asp Asn Thr Leu Asp Val Met Lys Lys Pro Arg Cys 
                85                  90                  95      


Gly Val Pro Asp Val Gly Glu Tyr Asn Val Phe Pro Arg Thr Leu Lys 
            100                 105                 110         


Trp Ser Lys Met Asn Leu Thr Tyr Arg Ile Val Asn Tyr Thr Pro Asp 
        115                 120                 125             


Met Thr His Ser Glu Val Glu Lys Ala Phe Lys Lys Ala Phe Lys Val 
    130                 135                 140                 


Trp Ser Asp Val Thr Pro Leu Asn Phe Thr Arg Leu His Asp Gly Ile 
145                 150                 155                 160 


Ala Asp Ile Met Ile Ser Phe Gly Ile Lys Glu His Gly Asp Phe Tyr 
                165                 170                 175     


Pro Phe Asp Gly Pro Ser Gly Leu Leu Ala His Ala Phe Pro Pro Gly 
            180                 185                 190         


Pro Asn Tyr Gly Gly Asp Ala His Phe Asp Asp Asp Glu Thr Trp Thr 
        195                 200                 205             


Ser Ser Ser Lys Gly Tyr Asn Leu Phe Leu Val Ala Ala His Glu Phe 
    210                 215                 220                 


Gly His Ser Leu Gly Leu Asp His Ser Lys Asp Pro Gly Ala Leu Met 
225                 230                 235                 240 


Phe Pro Ile Tyr Thr Tyr Thr Gly Lys Ser His Phe Met Leu Pro Asp 
                245                 250                 255     


Asp Asp Val Gln Gly Ile Gln Ser Leu Tyr Gly Pro Gly Asp Glu Asp 
            260                 265                 270         


Pro Asn Pro Lys His Pro Lys Thr Pro Asp Lys Cys Asp Pro Ser Leu 
        275                 280                 285             


Ser Leu Asp Ala Ile Thr Ser Leu Arg Gly Glu Thr Met Ile Phe Lys 
    290                 295                 300                 


Asp Arg Phe Phe Trp Arg Leu His Pro Gln Gln Val Asp Ala Glu Leu 
305                 310                 315                 320 


Phe Leu Thr Lys Ser Phe Trp Pro Glu Leu Pro Asn Arg Ile Asp Ala 
                325                 330                 335     


Ala Tyr Glu His Pro Ser His Asp Leu Ile Phe Ile Phe Arg Gly Arg 
            340                 345                 350         


Lys Phe Trp Ala Leu Asn Gly Tyr Asp Ile Leu Glu Gly Tyr Pro Lys 
        355                 360                 365             


Lys Ile Ser Glu Leu Gly Leu Pro Lys Glu Val Lys Lys Ile Ser Ala 
    370                 375                 380                 


Ala Val His Phe Glu Asp Thr Gly Lys Thr Leu Leu Phe Ser Gly Asn 
385                 390                 395                 400 


Gln Val Trp Arg Tyr Asp Asp Thr Asn His Ile Met Asp Lys Asp Tyr 
                405                 410                 415     


Pro Arg Leu Ile Glu Glu Asp Phe Pro Gly Ile Gly Asp Lys Val Asp 
            420                 425                 430         


Ala Val Tyr Glu Lys Asn Glu Ser His Ser Val Thr Gln Ala Gly Val 
        435                 440                 445             


His Cys Arg Asn Leu Ser Ser Leu Gln Pro Pro Pro Pro Gly Phe Lys 
    450                 455                 460                 


Arg Phe Ser Cys Leu Ser Leu Trp Ser Ser Trp Asp Tyr Arg Leu Tyr 
465                 470                 475                 480 


Leu Phe Phe Gln Arg Thr His Thr Val 
                485                 


<210>  8771
<211>  383
<212>  PRT
<213>  Homo Sapiens

<400>  8771

Met His Pro Gly Val Leu Ala Ala Phe Leu Phe Leu Ser Trp Thr His 
1               5                   10                  15      


Cys Arg Ala Leu Pro Leu Pro Ser Gly Gly Asp Glu Asp Asp Leu Ser 
            20                  25                  30          


Glu Glu Asp Leu Gln Phe Ala Glu Arg Tyr Leu Arg Ser Tyr Tyr His 
        35                  40                  45              


Pro Thr Asn Leu Ala Gly Ile Leu Lys Glu Asn Ala Ala Ser Ser Met 
    50                  55                  60                  


Thr Glu Arg Leu Arg Glu Met Gln Ser Phe Phe Gly Leu Glu Val Thr 
65                  70                  75                  80  


Gly Lys Leu Asp Asp Asn Thr Leu Asp Val Met Lys Lys Pro Arg Cys 
                85                  90                  95      


Gly Val Pro Asp Val Gly Glu Tyr Asn Val Phe Pro Arg Thr Leu Lys 
            100                 105                 110         


Trp Ser Lys Met Asn Leu Thr Tyr Arg Ile Val Asn Tyr Thr Pro Asp 
        115                 120                 125             


Met Thr His Ser Glu Val Glu Lys Ala Phe Lys Lys Ala Phe Lys Val 
    130                 135                 140                 


Trp Ser Asp Val Thr Pro Leu Asn Phe Thr Arg Leu His Asp Gly Ile 
145                 150                 155                 160 


Ala Asp Ile Met Ile Ser Phe Gly Ile Lys Glu His Gly Asp Phe Tyr 
                165                 170                 175     


Pro Phe Asp Gly Pro Ser Gly Leu Leu Ala His Ala Phe Pro Pro Gly 
            180                 185                 190         


Pro Asn Tyr Gly Gly Asp Ala His Phe Asp Asp Asp Glu Thr Trp Thr 
        195                 200                 205             


Ser Ser Ser Lys Gly Tyr Asn Leu Phe Leu Val Ala Ala His Glu Phe 
    210                 215                 220                 


Gly His Ser Leu Gly Leu Asp His Ser Lys Asp Pro Gly Ala Leu Met 
225                 230                 235                 240 


Phe Pro Ile Tyr Thr Tyr Thr Gly Lys Ser His Phe Met Leu Pro Asp 
                245                 250                 255     


Asp Asp Val Gln Gly Ile Gln Ser Leu Tyr Gly Pro Gly Asp Glu Asp 
            260                 265                 270         


Pro Asn Pro Lys His Pro Lys Thr Pro Asp Lys Cys Asp Pro Ser Leu 
        275                 280                 285             


Ser Leu Asp Ala Ile Thr Ser Leu Arg Gly Glu Thr Met Ile Phe Lys 
    290                 295                 300                 


Asp Arg Phe Phe Trp Arg Leu His Pro Gln Gln Val Asp Ala Glu Leu 
305                 310                 315                 320 


Phe Leu Thr Lys Ser Phe Trp Pro Glu Leu Pro Asn Arg Ile Asp Ala 
                325                 330                 335     


Ala Tyr Glu His Pro Ser His Asp Leu Ile Phe Ile Phe Arg Gly Arg 
            340                 345                 350         


Lys Phe Trp Ala Leu Asn Gly Tyr Asp Ile Leu Glu Gly Tyr Pro Lys 
        355                 360                 365             


Lys Ile Ser Glu Leu Gly Leu Pro Lys Glu Val Asn Lys Leu Gln 
    370                 375                 380             


<210>  8772
<211>  194
<212>  PRT
<213>  Homo Sapiens

<400>  8772

Met Arg Glu Ser Leu Leu Phe Leu Arg Leu Pro Ser Ser Pro Ala Leu 
1               5                   10                  15      


Ser Arg Arg Arg Ala Leu Arg Trp Ala Leu Arg Pro Pro Arg Val Ala 
            20                  25                  30          


Gln Ala Phe Ser Gly Arg Val Cys Gly Gln Ala Trp Leu Gln Gln Tyr 
        35                  40                  45              


Gly Tyr Leu Pro Pro Gly Asp Leu Arg Thr His Thr Gln Arg Ser Pro 
    50                  55                  60                  


Gln Ser Leu Ser Ala Ala Ile Ala Ala Met Gln Lys Phe Tyr Gly Leu 
65                  70                  75                  80  


Gln Val Thr Gly Lys Ala Asp Ala Asp Thr Met Lys Ala Met Arg Arg 
                85                  90                  95      


Pro Arg Cys Gly Val Pro Asp Lys Phe Gly Ala Glu Ile Lys Ala Asn 
            100                 105                 110         


Val Arg Arg Lys Arg Tyr Ala Ile Gln Gly Leu Lys Trp Gln His Asn 
        115                 120                 125             


Glu Ile Thr Phe Cys Ile Gln Asn Tyr Thr Pro Lys Val Gly Glu Tyr 
    130                 135                 140                 


Ala Thr Tyr Glu Ala Ile Arg Lys Ala Phe Arg Val Trp Glu Ser Ala 
145                 150                 155                 160 


Thr Pro Leu Arg Phe Arg Glu Val Pro Tyr Ala Tyr Ile Arg Glu Gly 
                165                 170                 175     


His Glu Lys Gln Ala Asp Ile Met Ile Phe Phe Ala Glu Gly Phe His 
            180                 185                 190         


Gly Asp 
        


<210>  8773
<211>  582
<212>  PRT
<213>  Homo Sapiens

<400>  8773

Met Ser Pro Ala Pro Arg Pro Pro Arg Cys Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Thr Leu Gly Thr Ala Leu Ala Ser Leu Gly Ser Ala Gln Ser Ser Ser 
            20                  25                  30          


Phe Ser Pro Glu Ala Trp Leu Gln Gln Tyr Gly Tyr Leu Pro Pro Gly 
        35                  40                  45              


Asp Leu Arg Thr His Thr Gln Arg Ser Pro Gln Ser Leu Ser Ala Ala 
    50                  55                  60                  


Ile Ala Ala Met Gln Lys Phe Tyr Gly Leu Gln Val Thr Gly Lys Ala 
65                  70                  75                  80  


Asp Ala Asp Thr Met Lys Ala Met Arg Arg Pro Arg Cys Gly Val Pro 
                85                  90                  95      


Asp Lys Phe Gly Ala Glu Ile Lys Ala Asn Val Arg Arg Lys Arg Tyr 
            100                 105                 110         


Ala Ile Gln Gly Leu Lys Trp Gln His Asn Glu Ile Thr Phe Cys Ile 
        115                 120                 125             


Gln Asn Tyr Thr Pro Lys Val Gly Glu Tyr Ala Thr Tyr Glu Ala Ile 
    130                 135                 140                 


Arg Lys Ala Phe Arg Val Trp Glu Ser Ala Thr Pro Leu Arg Phe Arg 
145                 150                 155                 160 


Glu Val Pro Tyr Ala Tyr Ile Arg Glu Gly His Glu Lys Gln Ala Asp 
                165                 170                 175     


Ile Met Ile Phe Phe Ala Glu Gly Phe His Gly Asp Ser Thr Pro Phe 
            180                 185                 190         


Asp Gly Glu Gly Gly Phe Leu Ala His Ala Tyr Phe Pro Gly Pro Asn 
        195                 200                 205             


Ile Gly Gly Asp Thr His Phe Asp Ser Ala Glu Pro Trp Thr Val Arg 
    210                 215                 220                 


Asn Glu Asp Leu Asn Gly Asn Asp Ile Phe Leu Val Ala Val His Glu 
225                 230                 235                 240 


Leu Gly His Ala Leu Gly Leu Glu His Ser Ser Asp Pro Ser Ala Ile 
                245                 250                 255     


Met Ala Pro Phe Tyr Gln Trp Met Asp Thr Glu Asn Phe Val Leu Pro 
            260                 265                 270         


Asp Asp Asp Arg Arg Gly Ile Gln Gln Leu Tyr Gly Gly Glu Ser Gly 
        275                 280                 285             


Phe Pro Thr Lys Met Pro Pro Gln Pro Arg Thr Thr Ser Arg Pro Ser 
    290                 295                 300                 


Val Pro Asp Lys Pro Lys Asn Pro Thr Tyr Gly Pro Asn Ile Cys Asp 
305                 310                 315                 320 


Gly Asn Phe Asp Thr Val Ala Met Leu Arg Gly Glu Met Phe Val Phe 
                325                 330                 335     


Lys Glu Arg Trp Phe Trp Arg Val Arg Asn Asn Gln Val Met Asp Gly 
            340                 345                 350         


Tyr Pro Met Pro Ile Gly Gln Phe Trp Arg Gly Leu Pro Ala Ser Ile 
        355                 360                 365             


Asn Thr Ala Tyr Glu Arg Lys Asp Gly Lys Phe Val Phe Phe Lys Gly 
    370                 375                 380                 


Asp Lys His Trp Val Phe Asp Glu Ala Ser Leu Glu Pro Gly Tyr Pro 
385                 390                 395                 400 


Lys His Ile Lys Glu Leu Gly Arg Gly Leu Pro Thr Asp Lys Ile Asp 
                405                 410                 415     


Ala Ala Leu Phe Trp Met Pro Asn Gly Lys Thr Tyr Phe Phe Arg Gly 
            420                 425                 430         


Asn Lys Tyr Tyr Arg Phe Asn Glu Glu Leu Arg Ala Val Asp Ser Glu 
        435                 440                 445             


Tyr Pro Lys Asn Ile Lys Val Trp Glu Gly Ile Pro Glu Ser Pro Arg 
    450                 455                 460                 


Gly Ser Phe Met Gly Ser Asp Glu Val Phe Thr Tyr Phe Tyr Lys Gly 
465                 470                 475                 480 


Asn Lys Tyr Trp Lys Phe Asn Asn Gln Lys Leu Lys Val Glu Pro Gly 
                485                 490                 495     


Tyr Pro Lys Ser Ala Leu Arg Asp Trp Met Gly Cys Pro Ser Gly Gly 
            500                 505                 510         


Arg Pro Asp Glu Gly Thr Glu Glu Glu Thr Glu Val Ile Ile Ile Glu 
        515                 520                 525             


Val Asp Glu Glu Gly Gly Gly Ala Val Ser Ala Ala Ala Val Val Leu 
    530                 535                 540                 


Pro Val Leu Leu Leu Leu Leu Val Leu Ala Val Gly Leu Ala Val Phe 
545                 550                 555                 560 


Phe Phe Arg Arg His Gly Thr Pro Arg Arg Leu Leu Tyr Cys Gln Arg 
                565                 570                 575     


Ser Leu Leu Asp Lys Val 
            580         


<210>  8774
<211>  71
<212>  PRT
<213>  Homo Sapiens

<400>  8774

Met Ser Pro Ala Pro Arg Pro Pro Arg Cys Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Thr Leu Gly Thr Ala Leu Ala Ser Leu Gly Ser Ala Gln Ser Ser Ser 
            20                  25                  30          


Phe Ser Pro Glu Ser Leu Glu Glu Leu Tyr Asn Trp Gly Glu Leu Pro 
        35                  40                  45              


Leu Pro Arg Phe Pro Trp Ala Leu Leu Ser Ala Leu Glu Pro Pro Asp 
    50                  55                  60                  


Lys His Leu Asp Ser Ala Gln 
65                  70      


<210>  8775
<211>  143
<212>  PRT
<213>  Homo Sapiens

<400>  8775

Met Asp Pro Gly Tyr Pro Ala Gln Ser Pro Leu Trp Arg Gly Val Pro 
1               5                   10                  15      


Ser Thr Leu Asp Asp Ala Met Arg Trp Ser Asp Gly Ala Ser Tyr Phe 
            20                  25                  30          


Phe Arg Gly Gln Glu Tyr Trp Lys Val Leu Asp Gly Glu Leu Glu Val 
        35                  40                  45              


Ala Pro Gly Tyr Pro Gln Ser Thr Ala Arg Asp Trp Leu Val Cys Gly 
    50                  55                  60                  


Asp Ser Gln Ala Asp Gly Ser Val Ala Ala Gly Val Asp Ala Ala Glu 
65                  70                  75                  80  


Gly Pro Arg Ala Pro Pro Gly Gln His Asp Gln Ser Arg Ser Glu Asp 
                85                  90                  95      


Gly Tyr Glu Val Cys Ser Cys Thr Ser Gly Ala Ser Ser Pro Pro Gly 
            100                 105                 110         


Ala Pro Gly Pro Leu Val Ala Ala Thr Met Leu Leu Leu Leu Pro Pro 
        115                 120                 125             


Leu Ser Pro Gly Ala Leu Trp Thr Ala Ala Gln Ala Leu Thr Leu 
    130                 135                 140             


<210>  8776
<211>  118
<212>  PRT
<213>  Homo Sapiens

<400>  8776

Met His Arg Phe Trp Arg Gly Leu Pro Leu His Leu Asp Ser Val Asp 
1               5                   10                  15      


Ala Val Tyr Glu Arg Thr Ser Asp His Lys Ile Val Phe Phe Lys Gly 
            20                  25                  30          


Asp Arg Tyr Trp Val Phe Lys Asp Asn Asn Val Glu Glu Gly Tyr Pro 
        35                  40                  45              


Arg Pro Val Ser Asp Phe Ser Leu Pro Pro Gly Gly Ile Asp Ala Ala 
    50                  55                  60                  


Phe Ser Trp Ala His Asn Asp Arg Thr Tyr Phe Phe Lys Asp Gln Leu 
65                  70                  75                  80  


Tyr Trp Arg Tyr Asp Asp His Thr Arg His Met Asp Pro Gly Tyr Pro 
                85                  90                  95      


Ala Gln Ser Pro Leu Trp Arg Gly Val Pro Ser Thr Leu Asp Asp Ala 
            100                 105                 110         


Met Arg Trp Ser Asp Gly 
        115             


<210>  8777
<211>  39
<212>  PRT
<213>  Homo Sapiens

<400>  8777

Met His Arg Phe Trp Arg Gly Leu Pro Leu His Leu Asp Ser Val Asp 
1               5                   10                  15      


Ala Val Tyr Glu Arg Thr Ser Asp His Lys Ile Val Phe Phe Lys Gly 
            20                  25                  30          


Pro Ala Val Leu Ala Leu Arg 
        35                  


<210>  8778
<211>  169
<212>  PRT
<213>  Homo Sapiens

<400>  8778

Met Lys Thr Pro Arg Cys Ser Leu Pro Asp Leu Pro Val Leu Thr Gln 
1               5                   10                  15      


Ala Arg Arg Arg Arg Gln Ala Pro Ala Pro Thr Lys Trp Asn Lys Arg 
            20                  25                  30          


Asn Leu Ser Trp Arg Val Arg Thr Phe Pro Arg Asp Ser Pro Leu Gly 
        35                  40                  45              


His Asp Thr Val Arg Ala Leu Met Tyr Tyr Ala Leu Lys Val Trp Ser 
    50                  55                  60                  


Asp Ile Ala Pro Leu Asn Phe His Glu Val Ala Gly Ser Ala Ala Asp 
65                  70                  75                  80  


Ile Gln Ile Asp Phe Ser Lys Ala Asp His Asn Asp Gly Tyr Pro Phe 
                85                  90                  95      


Asp Gly Pro Gly Gly Thr Val Ala His Ala Phe Phe Pro Gly His His 
            100                 105                 110         


His Thr Ala Gly Asp Thr His Phe Asp Asp Asp Glu Ala Trp Thr Phe 
        115                 120                 125             


Arg Ser Ser Asp Ala His Gly Met Asp Leu Phe Ala Val Ala Val His 
    130                 135                 140                 


Glu Phe Gly His Ala Ile Gly Leu Ser His Val Ala Ala Ala His Ser 
145                 150                 155                 160 


Ile Met Arg Pro Tyr Tyr Gln Gly Pro 
                165                 


<210>  8779
<211>  115
<212>  PRT
<213>  Homo Sapiens

<400>  8779

Met Gln Gln Phe Gly Gly Leu Glu Ala Thr Gly Ile Leu Asp Glu Ala 
1               5                   10                  15      


Thr Leu Ala Leu Met Lys Thr Pro Arg Cys Ser Leu Pro Asp Leu Pro 
            20                  25                  30          


Val Leu Thr Gln Ala Arg Arg Arg Arg Gln Ala Pro Ala Pro Thr Lys 
        35                  40                  45              


Trp Asn Lys Arg Asn Leu Ser Trp Arg Val Arg Thr Phe Pro Arg Asp 
    50                  55                  60                  


Ser Pro Leu Gly His Asp Thr Val Arg Ala Leu Met Tyr Tyr Ala Leu 
65                  70                  75                  80  


Lys Val Trp Ser Asp Ile Ala Pro Leu Asn Phe His Glu Val Ala Gly 
                85                  90                  95      


Ser Ala Ala Asp Ile Gln Ile Asp Phe Ser Lys Ala Asp His Asn Asp 
            100                 105                 110         


Gly Tyr Pro 
        115 


<210>  8780
<211>  519
<212>  PRT
<213>  Homo Sapiens

<400>  8780

Met Gln Gln Phe Gly Gly Leu Glu Ala Thr Gly Ile Leu Asp Glu Ala 
1               5                   10                  15      


Thr Leu Ala Leu Met Lys Thr Pro Arg Cys Ser Leu Pro Asp Leu Pro 
            20                  25                  30          


Val Leu Thr Gln Ala Arg Arg Arg Arg Gln Ala Pro Ala Pro Thr Lys 
        35                  40                  45              


Trp Asn Lys Arg Asn Leu Ser Trp Arg Val Arg Thr Phe Pro Arg Asp 
    50                  55                  60                  


Ser Pro Leu Gly His Asp Thr Val Arg Ala Leu Met Tyr Tyr Ala Leu 
65                  70                  75                  80  


Lys Val Trp Ser Asp Ile Ala Pro Leu Asn Phe His Glu Val Ala Gly 
                85                  90                  95      


Ser Ala Ala Asp Ile Gln Ile Asp Phe Ser Lys Ala Asp His Asn Asp 
            100                 105                 110         


Gly Tyr Pro Phe Asp Gly Pro Gly Gly Thr Val Ala His Ala Phe Phe 
        115                 120                 125             


Pro Gly His His His Thr Ala Gly Asp Thr His Phe Asp Asp Asp Glu 
    130                 135                 140                 


Ala Trp Thr Phe Arg Ser Ser Asp Ala His Gly Met Asp Leu Phe Ala 
145                 150                 155                 160 


Val Ala Val His Glu Phe Gly His Ala Ile Gly Leu Ser His Val Ala 
                165                 170                 175     


Ala Ala His Ser Ile Met Arg Pro Tyr Tyr Gln Gly Pro Val Gly Asp 
            180                 185                 190         


Pro Leu Arg Tyr Gly Leu Pro Tyr Glu Asp Lys Val Arg Val Trp Gln 
        195                 200                 205             


Leu Tyr Gly Val Arg Glu Ser Val Ser Pro Thr Ala Gln Pro Glu Glu 
    210                 215                 220                 


Pro Pro Leu Leu Pro Glu Pro Pro Asp Asn Arg Ser Ser Ala Pro Pro 
225                 230                 235                 240 


Arg Lys Asp Val Pro His Arg Cys Ser Thr His Phe Asp Ala Val Ala 
                245                 250                 255     


Gln Ile Arg Gly Glu Ala Phe Phe Phe Lys Gly Lys Tyr Phe Trp Arg 
            260                 265                 270         


Leu Thr Arg Asp Arg His Leu Val Ser Leu Gln Pro Ala Gln Met His 
        275                 280                 285             


Arg Phe Trp Arg Gly Leu Pro Leu His Leu Asp Ser Val Asp Ala Val 
    290                 295                 300                 


Tyr Glu Arg Thr Ser Asp His Lys Ile Val Phe Phe Lys Gly Asp Arg 
305                 310                 315                 320 


Tyr Trp Val Phe Lys Asp Asn Asn Val Glu Glu Gly Tyr Pro Arg Pro 
                325                 330                 335     


Val Ser Asp Phe Ser Leu Pro Pro Gly Gly Ile Asp Ala Ala Phe Ser 
            340                 345                 350         


Trp Ala His Asn Asp Arg Thr Tyr Phe Phe Lys Asp Gln Leu Tyr Trp 
        355                 360                 365             


Arg Tyr Asp Asp His Thr Arg His Met Asp Pro Gly Tyr Pro Ala Gln 
    370                 375                 380                 


Ser Pro Leu Trp Arg Gly Val Pro Ser Thr Leu Asp Asp Ala Met Arg 
385                 390                 395                 400 


Trp Ser Asp Gly Ala Ser Tyr Phe Phe Arg Gly Gln Glu Tyr Trp Lys 
                405                 410                 415     


Val Leu Asp Gly Glu Leu Glu Val Ala Pro Gly Tyr Pro Gln Ser Thr 
            420                 425                 430         


Ala Arg Asp Trp Leu Val Cys Gly Asp Ser Gln Ala Asp Gly Ser Val 
        435                 440                 445             


Ala Ala Gly Val Asp Ala Ala Glu Gly Pro Arg Ala Pro Pro Gly Gln 
    450                 455                 460                 


His Asp Gln Ser Arg Ser Glu Asp Gly Tyr Glu Val Cys Ser Cys Thr 
465                 470                 475                 480 


Ser Gly Ala Ser Ser Pro Pro Gly Ala Pro Gly Pro Leu Val Ala Ala 
                485                 490                 495     


Thr Met Leu Leu Leu Leu Pro Pro Leu Ser Pro Gly Ala Leu Trp Thr 
            500                 505                 510         


Ala Ala Gln Ala Leu Thr Leu 
        515                 


<210>  8781
<211>  603
<212>  PRT
<213>  Homo Sapiens

<400>  8781

Met Arg Arg Arg Ala Ala Arg Gly Pro Gly Pro Pro Pro Pro Gly Pro 
1               5                   10                  15      


Gly Leu Ser Arg Leu Pro Leu Pro Leu Leu Leu Leu Leu Ala Leu Gly 
            20                  25                  30          


Thr Arg Gly Gly Cys Ala Ala Pro Ala Pro Ala Pro Arg Ala Glu Asp 
        35                  40                  45              


Leu Ser Leu Gly Val Glu Trp Leu Ser Arg Phe Gly Tyr Leu Pro Pro 
    50                  55                  60                  


Ala Asp Pro Thr Thr Gly Gln Leu Gln Thr Gln Glu Glu Leu Ser Lys 
65                  70                  75                  80  


Ala Ile Thr Ala Met Gln Gln Phe Gly Gly Leu Glu Ala Thr Gly Ile 
                85                  90                  95      


Leu Asp Glu Ala Thr Leu Ala Leu Met Lys Thr Pro Arg Cys Ser Leu 
            100                 105                 110         


Pro Asp Leu Pro Val Leu Thr Gln Ala Arg Arg Arg Arg Gln Ala Pro 
        115                 120                 125             


Ala Pro Thr Lys Trp Asn Lys Arg Asn Leu Ser Trp Arg Val Arg Thr 
    130                 135                 140                 


Phe Pro Arg Asp Ser Pro Leu Gly His Asp Thr Val Arg Ala Leu Met 
145                 150                 155                 160 


Tyr Tyr Ala Leu Lys Val Trp Ser Asp Ile Ala Pro Leu Asn Phe His 
                165                 170                 175     


Glu Val Ala Gly Ser Ala Ala Asp Ile Gln Ile Asp Phe Ser Lys Ala 
            180                 185                 190         


Asp His Asn Asp Gly Tyr Pro Phe Asp Gly Pro Gly Gly Thr Val Ala 
        195                 200                 205             


His Ala Phe Phe Pro Gly His His His Thr Ala Gly Asp Thr His Phe 
    210                 215                 220                 


Asp Asp Asp Glu Ala Trp Thr Phe Arg Ser Ser Asp Ala His Gly Met 
225                 230                 235                 240 


Asp Leu Phe Ala Val Ala Val His Glu Phe Gly His Ala Ile Gly Leu 
                245                 250                 255     


Ser His Val Ala Ala Ala His Ser Ile Met Arg Pro Tyr Tyr Gln Gly 
            260                 265                 270         


Pro Val Gly Asp Pro Leu Arg Tyr Gly Leu Pro Tyr Glu Asp Lys Val 
        275                 280                 285             


Arg Val Trp Gln Leu Tyr Gly Val Arg Glu Ser Val Ser Pro Thr Ala 
    290                 295                 300                 


Gln Pro Glu Glu Pro Pro Leu Leu Pro Glu Pro Pro Asp Asn Arg Ser 
305                 310                 315                 320 


Ser Ala Pro Pro Arg Lys Asp Val Pro His Arg Cys Ser Thr His Phe 
                325                 330                 335     


Asp Ala Val Ala Gln Ile Arg Gly Glu Ala Phe Phe Phe Lys Gly Lys 
            340                 345                 350         


Tyr Phe Trp Arg Leu Thr Arg Asp Arg His Leu Val Ser Leu Gln Pro 
        355                 360                 365             


Ala Gln Met His Arg Phe Trp Arg Gly Leu Pro Leu His Leu Asp Ser 
    370                 375                 380                 


Val Asp Ala Val Tyr Glu Arg Thr Ser Asp His Lys Ile Val Phe Phe 
385                 390                 395                 400 


Lys Gly Asp Arg Tyr Trp Val Phe Lys Asp Asn Asn Val Glu Glu Gly 
                405                 410                 415     


Tyr Pro Arg Pro Val Ser Asp Phe Ser Leu Pro Pro Gly Gly Ile Asp 
            420                 425                 430         


Ala Ala Phe Ser Trp Ala His Asn Asp Arg Thr Tyr Phe Phe Lys Asp 
        435                 440                 445             


Gln Leu Tyr Trp Arg Tyr Asp Asp His Thr Arg His Met Asp Pro Gly 
    450                 455                 460                 


Tyr Pro Ala Gln Ser Pro Leu Trp Arg Gly Val Pro Ser Thr Leu Asp 
465                 470                 475                 480 


Asp Ala Met Arg Trp Ser Asp Gly Ala Ser Tyr Phe Phe Arg Gly Gln 
                485                 490                 495     


Glu Tyr Trp Lys Val Leu Asp Gly Glu Leu Glu Val Ala Pro Gly Tyr 
            500                 505                 510         


Pro Gln Ser Thr Ala Arg Asp Trp Leu Val Cys Gly Asp Ser Gln Ala 
        515                 520                 525             


Asp Gly Ser Val Ala Ala Gly Val Asp Ala Ala Glu Gly Pro Arg Ala 
    530                 535                 540                 


Pro Pro Gly Gln His Asp Gln Ser Arg Ser Glu Asp Gly Tyr Glu Val 
545                 550                 555                 560 


Cys Ser Cys Thr Ser Gly Ala Ser Ser Pro Pro Gly Ala Pro Gly Pro 
                565                 570                 575     


Leu Val Ala Ala Thr Met Leu Leu Leu Leu Pro Pro Leu Ser Pro Gly 
            580                 585                 590         


Ala Leu Trp Thr Ala Ala Gln Ala Leu Thr Leu 
        595                 600             


<210>  8782
<211>  302
<212>  PRT
<213>  Homo Sapiens

<400>  8782

Met Tyr Tyr Ala Leu Lys Val Trp Ser Asp Ile Ala Pro Leu Asn Phe 
1               5                   10                  15      


His Glu Val Ala Gly Ser Ala Ala Asp Ile Gln Ile Asp Phe Ser Lys 
            20                  25                  30          


Ala Asp His Asn Asp Gly Tyr Pro Phe Asp Gly Pro Gly Gly Thr Val 
        35                  40                  45              


Ala His Ala Phe Phe Pro Gly His His His Thr Ala Gly Asp Thr His 
    50                  55                  60                  


Phe Asp Asp Asp Glu Ala Trp Thr Phe Arg Ser Ser Asp Ala His Gly 
65                  70                  75                  80  


Met Asp Leu Phe Ala Val Ala Val His Glu Phe Gly His Ala Ile Gly 
                85                  90                  95      


Leu Ser His Val Ala Ala Ala His Ser Ile Met Arg Pro Tyr Tyr Gln 
            100                 105                 110         


Gly Pro Val Gly Asp Pro Leu Arg Tyr Gly Leu Pro Tyr Glu Asp Lys 
        115                 120                 125             


Val Arg Val Trp Gln Leu Tyr Gly Val Arg Glu Ser Val Ser Pro Thr 
    130                 135                 140                 


Ala Gln Pro Glu Glu Pro Pro Leu Leu Pro Glu Pro Pro Asp Asn Arg 
145                 150                 155                 160 


Ser Ser Ala Pro Pro Arg Lys Asp Val Pro His Arg Cys Ser Thr His 
                165                 170                 175     


Phe Asp Ala Val Ala Gln Ile Arg Gly Glu Ala Phe Phe Phe Lys Gly 
            180                 185                 190         


Lys Tyr Phe Trp Arg Leu Thr Arg Asp Arg His Leu Val Ser Leu Gln 
        195                 200                 205             


Pro Ala Gln Met His Arg Phe Trp Arg Gly Leu Pro Leu His Leu Asp 
    210                 215                 220                 


Ser Val Asp Ala Val Tyr Glu Arg Thr Ser Asp His Lys Ile Val Phe 
225                 230                 235                 240 


Phe Lys Gly Asp Arg Tyr Trp Val Phe Lys Asp Asn Asn Val Glu Glu 
                245                 250                 255     


Gly Tyr Pro Arg Pro Val Ser Asp Phe Ser Leu Pro Pro Gly Gly Ile 
            260                 265                 270         


Asp Ala Ala Phe Ser Trp Ala His Asn Asp Arg Thr Tyr Phe Phe Lys 
        275                 280                 285             


Asp Gln Leu Tyr Trp Arg Tyr Asp Asp His Thr Arg His Met 
    290                 295                 300         


<210>  8783
<211>  485
<212>  PRT
<213>  Homo Sapiens

<400>  8783

Met Asn Cys Gln Gln Leu Trp Leu Gly Phe Leu Leu Pro Met Thr Val 
1               5                   10                  15      


Ser Gly Arg Val Leu Gly Leu Ala Glu Val Ala Pro Val Asp Tyr Leu 
            20                  25                  30          


Ser Gln Tyr Gly Tyr Leu Gln Lys Pro Leu Glu Gly Ser Asn Asn Phe 
        35                  40                  45              


Lys Pro Glu Asp Ile Thr Glu Ala Leu Arg Ala Phe Gln Glu Ala Ser 
    50                  55                  60                  


Glu Leu Pro Val Ser Gly Gln Leu Asp Asp Ala Thr Arg Ala Arg Met 
65                  70                  75                  80  


Arg Gln Pro Arg Cys Gly Leu Glu Asp Pro Phe Asn Gln Lys Thr Leu 
                85                  90                  95      


Lys Tyr Leu Leu Leu Ala Arg Ala Ala Leu Arg Gln Ala Phe Gln Asp 
            100                 105                 110         


Trp Ser Asn Val Ala Pro Leu Thr Phe Gln Glu Val Gln Ala Gly Ala 
        115                 120                 125             


Ala Asp Ile Arg Leu Ser Phe His Gly Arg Gln Ser Ser Tyr Cys Ser 
    130                 135                 140                 


Asn Thr Phe Asp Gly Pro Gly Arg Val Leu Ala His Ala Asp Ile Pro 
145                 150                 155                 160 


Glu Leu Gly Ser Val His Phe Asp Glu Asp Glu Phe Trp Thr Glu Gly 
                165                 170                 175     


Thr Tyr Arg Gly Val Asn Leu Arg Ile Ile Ala Ala His Glu Val Gly 
            180                 185                 190         


His Ala Leu Gly Leu Gly His Ser Arg Tyr Ser Gln Ala Leu Met Ala 
        195                 200                 205             


Pro Val Tyr Glu Gly Tyr Arg Pro His Phe Lys Leu His Pro Asp Asp 
    210                 215                 220                 


Val Ala Gly Ile Gln Ala Leu Tyr Gly Lys Lys Ser Pro Val Ile Arg 
225                 230                 235                 240 


Asp Glu Glu Glu Glu Glu Thr Glu Leu Pro Thr Val Pro Pro Val Pro 
                245                 250                 255     


Thr Glu Pro Ser Pro Met Pro Asp Pro Cys Ser Ser Glu Leu Asp Ala 
            260                 265                 270         


Met Met Leu Gly Pro Arg Gly Lys Thr Tyr Ala Phe Lys Gly Asp Tyr 
        275                 280                 285             


Val Trp Thr Val Ser Asp Ser Gly Pro Gly Pro Leu Phe Arg Val Ser 
    290                 295                 300                 


Ala Leu Trp Glu Gly Leu Pro Gly Asn Leu Asp Ala Ala Val Tyr Ser 
305                 310                 315                 320 


Pro Arg Thr Gln Trp Ile His Phe Phe Lys Gly Asp Lys Val Trp Arg 
                325                 330                 335     


Tyr Ile Asn Phe Lys Met Ser Pro Gly Phe Pro Lys Lys Leu Asn Arg 
            340                 345                 350         


Val Glu Pro Asn Leu Asp Ala Ala Leu Tyr Trp Pro Leu Asn Gln Lys 
        355                 360                 365             


Val Phe Leu Phe Lys Gly Ser Gly Tyr Trp Gln Trp Asp Glu Leu Ala 
    370                 375                 380                 


Arg Thr Asp Phe Ser Ser Tyr Pro Lys Pro Ile Lys Gly Leu Phe Thr 
385                 390                 395                 400 


Gly Val Pro Asn Gln Pro Ser Ala Ala Met Ser Trp Gln Asp Gly Arg 
                405                 410                 415     


Val Tyr Phe Phe Lys Gly Lys Val Tyr Trp Arg Leu Asn Gln Gln Leu 
            420                 425                 430         


Arg Val Glu Lys Gly Tyr Pro Arg Asn Ile Ser His Asn Trp Met His 
        435                 440                 445             


Cys Arg Pro Arg Thr Ile Asp Thr Thr Pro Ser Gly Gly Asn Thr Thr 
    450                 455                 460                 


Pro Ser Gly Thr Gly Ile Thr Leu Asp Thr Thr Leu Ser Ala Thr Glu 
465                 470                 475                 480 


Thr Thr Phe Glu Tyr 
                485 


<210>  8784
<211>  305
<212>  PRT
<213>  Homo Sapiens

<400>  8784

Met Asn Cys Gln Gln Leu Trp Leu Gly Phe Leu Leu Pro Met Thr Val 
1               5                   10                  15      


Ser Gly Arg Val Leu Gly Leu Ala Glu Val Ala Pro Val Asp Tyr Leu 
            20                  25                  30          


Ser Gln Tyr Gly Tyr Leu Gln Lys Pro Leu Glu Gly Ser Asn Asn Phe 
        35                  40                  45              


Lys Pro Glu Asp Ile Thr Glu Ala Leu Arg Ala Phe Gln Glu Ala Ser 
    50                  55                  60                  


Glu Leu Pro Val Ser Gly Gln Leu Asp Asp Ala Thr Arg Ala Arg Met 
65                  70                  75                  80  


Arg Gln Pro Arg Cys Gly Leu Glu Asp Pro Phe Asn Gln Lys Thr Leu 
                85                  90                  95      


Lys Tyr Leu Leu Leu Gly Arg Trp Arg Lys Lys His Leu Thr Phe Arg 
            100                 105                 110         


Ile Leu Asn Leu Pro Ser Thr Leu Pro Pro His Thr Ala Arg Ala Ala 
        115                 120                 125             


Leu Arg Gln Ala Phe Gln Asp Trp Ser Asn Val Ala Pro Leu Thr Phe 
    130                 135                 140                 


Gln Glu Val Gln Ala Gly Ala Ala Asp Ile Arg Leu Ser Phe His Gly 
145                 150                 155                 160 


Arg Gln Ser Ser Tyr Cys Ser Asn Thr Phe Asp Gly Pro Gly Lys Lys 
                165                 170                 175     


Ser Pro Val Ile Arg Asp Glu Glu Glu Glu Glu Thr Glu Leu Pro Thr 
            180                 185                 190         


Val Pro Pro Val Pro Thr Glu Pro Ser Pro Met Pro Asp Pro Cys Ser 
        195                 200                 205             


Ser Glu Leu Asp Ala Met Met Leu Gly Glu Ala Pro Pro Leu Gln Ala 
    210                 215                 220                 


Val Gly Arg Arg Trp Gly Gln Pro Ala Asp Pro Glu Ala Trp Thr Asn 
225                 230                 235                 240 


Gly Ser Asp Met Gly Leu Gln His Glu Gln Trp Arg Ala Pro Trp Glu 
                245                 250                 255     


Asp Leu Cys Phe Gln Gly Gly Leu Cys Val Asp Cys Ile Arg Phe Arg 
            260                 265                 270         


Thr Gly Pro Leu Val Pro Ser Val Cys Pro Leu Gly Gly Ala Pro Arg 
        275                 280                 285             


Lys Pro Gly Cys Cys Cys Leu Leu Ala Ser Asn Thr Met Asp Ser Leu 
    290                 295                 300                 


Leu 
305 


<210>  8785
<211>  508
<212>  PRT
<213>  Homo Sapiens

<400>  8785

Met Asn Cys Gln Gln Leu Trp Leu Gly Phe Leu Leu Pro Met Thr Val 
1               5                   10                  15      


Ser Gly Arg Val Leu Gly Leu Ala Glu Val Ala Pro Val Asp Tyr Leu 
            20                  25                  30          


Ser Gln Tyr Gly Tyr Leu Gln Lys Pro Leu Glu Gly Ser Asn Asn Phe 
        35                  40                  45              


Lys Pro Glu Asp Ile Thr Glu Ala Leu Arg Ala Phe Gln Glu Ala Ser 
    50                  55                  60                  


Glu Leu Pro Val Ser Gly Gln Leu Asp Asp Ala Thr Arg Ala Arg Met 
65                  70                  75                  80  


Arg Gln Pro Arg Cys Gly Leu Glu Asp Pro Phe Asn Gln Lys Thr Leu 
                85                  90                  95      


Lys Tyr Leu Leu Leu Gly Arg Trp Arg Lys Lys His Leu Thr Phe Arg 
            100                 105                 110         


Ile Leu Asn Leu Pro Ser Thr Leu Pro Pro His Thr Ala Arg Ala Ala 
        115                 120                 125             


Leu Arg Gln Ala Phe Gln Asp Trp Ser Asn Val Ala Pro Leu Thr Phe 
    130                 135                 140                 


Gln Glu Val Gln Ala Gly Ala Ala Asp Ile Arg Leu Ser Phe His Gly 
145                 150                 155                 160 


Arg Gln Ser Ser Tyr Cys Ser Asn Thr Phe Asp Gly Pro Gly Arg Val 
                165                 170                 175     


Leu Ala His Ala Asp Ile Pro Glu Leu Gly Ser Val His Phe Asp Glu 
            180                 185                 190         


Asp Glu Phe Trp Thr Glu Gly Thr Tyr Arg Gly Val Asn Leu Arg Ile 
        195                 200                 205             


Ile Ala Ala His Glu Val Gly His Ala Leu Gly Leu Gly His Ser Arg 
    210                 215                 220                 


Tyr Ser Gln Ala Leu Met Ala Pro Val Tyr Glu Gly Tyr Arg Pro His 
225                 230                 235                 240 


Phe Lys Leu His Pro Asp Asp Val Ala Gly Ile Gln Ala Leu Tyr Gly 
                245                 250                 255     


Lys Lys Ser Pro Val Ile Arg Asp Glu Glu Glu Glu Glu Thr Glu Leu 
            260                 265                 270         


Pro Thr Val Pro Pro Val Pro Thr Glu Pro Ser Pro Met Pro Asp Pro 
        275                 280                 285             


Cys Ser Ser Glu Leu Asp Ala Met Met Leu Gly Pro Arg Gly Lys Thr 
    290                 295                 300                 


Tyr Ala Phe Lys Gly Asp Tyr Val Trp Thr Val Ser Asp Ser Gly Pro 
305                 310                 315                 320 


Gly Pro Leu Phe Arg Val Ser Ala Leu Trp Glu Gly Leu Pro Gly Asn 
                325                 330                 335     


Leu Asp Ala Ala Val Tyr Ser Pro Arg Thr Gln Trp Ile His Phe Phe 
            340                 345                 350         


Lys Gly Asp Lys Val Trp Arg Tyr Ile Asn Phe Lys Met Ser Pro Gly 
        355                 360                 365             


Phe Pro Lys Lys Leu Asn Arg Val Glu Pro Asn Leu Asp Ala Ala Leu 
    370                 375                 380                 


Tyr Trp Pro Leu Asn Gln Lys Val Phe Leu Phe Lys Gly Ser Gly Tyr 
385                 390                 395                 400 


Trp Gln Trp Asp Glu Leu Ala Arg Thr Asp Phe Ser Ser Tyr Pro Lys 
                405                 410                 415     


Pro Ile Lys Gly Leu Phe Thr Gly Val Pro Asn Gln Pro Ser Ala Ala 
            420                 425                 430         


Met Ser Trp Gln Asp Gly Arg Val Tyr Phe Phe Lys Gly Lys Val Tyr 
        435                 440                 445             


Trp Arg Leu Asn Gln Gln Leu Arg Val Glu Lys Gly Tyr Pro Arg Asn 
    450                 455                 460                 


Ile Ser His Asn Trp Met His Cys Arg Pro Arg Thr Ile Asp Thr Thr 
465                 470                 475                 480 


Pro Ser Gly Gly Asn Thr Thr Pro Ser Gly Thr Gly Ile Thr Leu Asp 
                485                 490                 495     


Thr Thr Leu Ser Ala Thr Glu Thr Thr Phe Glu Tyr 
            500                 505             


<210>  8786
<211>  81
<212>  PRT
<213>  Homo Sapiens

<400>  8786

Met Asn Cys Gln Gln Leu Trp Leu Gly Phe Leu Leu Pro Met Thr Val 
1               5                   10                  15      


Ser Gly Arg Val Leu Gly Leu Ala Glu Val Ala Pro Val Asp Tyr Leu 
            20                  25                  30          


Ser Gln Tyr Gly Tyr Leu Gln Lys Pro Leu Glu Gly Ser Asn Asn Phe 
        35                  40                  45              


Lys Pro Glu Asp Ile Thr Glu Ala Leu Arg Glu Ser Pro Gly Pro Cys 
    50                  55                  60                  


Arg His Pro Arg Ala Gly Gln Cys Ala Leu Arg Arg Arg Arg Val Leu 
65                  70                  75                  80  


Asp 
    


<210>  8787
<211>  108
<212>  PRT
<213>  Homo Sapiens

<400>  8787

Met Asn Cys Gln Gln Leu Trp Leu Gly Phe Leu Leu Pro Met Thr Val 
1               5                   10                  15      


Ser Gly Arg Val Leu Gly Leu Ala Glu Val Ala Pro Val Asp Tyr Leu 
            20                  25                  30          


Ser Gln Tyr Gly Tyr Leu Gln Lys Pro Leu Glu Gly Ser Asn Asn Phe 
        35                  40                  45              


Lys Pro Glu Asp Ile Thr Glu Ala Leu Arg Pro Leu Glu Lys Glu Ala 
    50                  55                  60                  


Pro Asp Phe Pro His Leu Glu Pro Ala Leu His Pro Ser Thr Pro His 
65                  70                  75                  80  


Ser Pro Gly Ser Pro Ala Ser Ser Leu Pro Gly Leu Glu Gln Cys Gly 
                85                  90                  95      


Ser Leu Asp Leu Pro Arg Gly Ala Gly Trp Cys Gly 
            100                 105             


<210>  8788
<211>  63
<212>  PRT
<213>  Homo Sapiens

<400>  8788

Met Asn Cys Gln Gln Leu Trp Leu Gly Phe Leu Leu Pro Met Thr Val 
1               5                   10                  15      


Ser Gly Arg Val Leu Gly Leu Ala Glu Val Ala Pro Val Asp Tyr Leu 
            20                  25                  30          


Ser Gln Tyr Gly Tyr Leu Gln Lys Pro Leu Glu Gly Ser Asn Asn Phe 
        35                  40                  45              


Lys Pro Glu Asp Ile Thr Glu Ala Leu Ser Leu Arg Ser Ala Gly 
    50                  55                  60              


<210>  8789
<211>  252
<212>  PRT
<213>  Homo Sapiens

<400>  8789

Gly Thr Thr Glu Asp Tyr Asp Arg Asp Lys Lys Tyr Gly Phe Cys Pro 
1               5                   10                  15      


Glu Thr Gly Tyr Ser Leu Phe Leu Val Ala Ala His Glu Phe Gly His 
            20                  25                  30          


Ala Met Gly Leu Glu His Ser Gln Asp Pro Gly Ala Leu Met Ala Pro 
        35                  40                  45              


Ile Tyr Thr Tyr Thr Lys Asn Phe Arg Leu Ser Gln Asp Asp Ile Lys 
    50                  55                  60                  


Gly Ile Gln Glu Leu Tyr Gly Ala Ser Pro Asp Ile Asp Leu Gly Thr 
65                  70                  75                  80  


Gly Pro Thr Pro Thr Leu Gly Pro Val Thr Pro Glu Ile Cys Lys Gln 
                85                  90                  95      


Asp Ile Val Phe Asp Gly Ile Ala Gln Ile Arg Gly Glu Ile Phe Phe 
            100                 105                 110         


Phe Lys Asp Arg Phe Ile Trp Arg Thr Val Thr Pro Arg Asp Lys Pro 
        115                 120                 125             


Met Gly Pro Leu Leu Val Ala Thr Phe Trp Pro Glu Leu Pro Glu Lys 
    130                 135                 140                 


Ile Asp Ala Val Tyr Glu Ala Pro Gln Glu Glu Lys Ala Val Phe Phe 
145                 150                 155                 160 


Ala Gly Asn Glu Tyr Trp Ile Tyr Ser Ala Ser Thr Leu Glu Arg Gly 
                165                 170                 175     


Tyr Pro Lys Pro Leu Thr Ser Leu Gly Leu Pro Pro Asp Val Gln Arg 
            180                 185                 190         


Val Asp Ala Ala Phe Asn Trp Ser Lys Asn Lys Lys Thr Tyr Ile Phe 
        195                 200                 205             


Ala Gly Asp Lys Phe Trp Arg Tyr Asn Glu Val Lys Lys Lys Met Asp 
    210                 215                 220                 


Pro Gly Phe Pro Lys Leu Ile Ala Asp Ala Trp Asn Ala Ile Pro Asp 
225                 230                 235                 240 


Asn Leu Asp Ala Val Val Asp Leu Gln Gly Gly Gly 
                245                 250         


<210>  8790
<211>  660
<212>  PRT
<213>  Homo Sapiens

<400>  8790

Met Glu Ala Leu Met Ala Arg Gly Ala Leu Thr Gly Pro Leu Arg Ala 
1               5                   10                  15      


Leu Cys Leu Leu Gly Cys Leu Leu Ser His Ala Ala Ala Ala Pro Ser 
            20                  25                  30          


Pro Ile Ile Lys Phe Pro Gly Asp Val Ala Pro Lys Thr Asp Lys Glu 
        35                  40                  45              


Leu Ala Val Gln Tyr Leu Asn Thr Phe Tyr Gly Cys Pro Lys Glu Ser 
    50                  55                  60                  


Cys Asn Leu Phe Val Leu Lys Asp Thr Leu Lys Lys Met Gln Lys Phe 
65                  70                  75                  80  


Phe Gly Leu Pro Gln Thr Gly Asp Leu Asp Gln Asn Thr Ile Glu Thr 
                85                  90                  95      


Met Arg Lys Pro Arg Cys Gly Asn Pro Asp Val Ala Asn Tyr Asn Phe 
            100                 105                 110         


Phe Pro Arg Lys Pro Lys Trp Asp Lys Asn Gln Ile Thr Tyr Arg Ile 
        115                 120                 125             


Ile Gly Tyr Thr Pro Asp Leu Asp Pro Glu Thr Val Asp Asp Ala Phe 
    130                 135                 140                 


Ala Arg Ala Phe Gln Val Trp Ser Asp Val Thr Pro Leu Arg Phe Ser 
145                 150                 155                 160 


Arg Ile His Asp Gly Glu Ala Asp Ile Met Ile Asn Phe Gly Arg Trp 
                165                 170                 175     


Glu His Gly Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly Leu Leu Ala 
            180                 185                 190         


His Ala Phe Ala Pro Gly Thr Gly Val Gly Gly Asp Ser His Phe Asp 
        195                 200                 205             


Asp Asp Glu Leu Trp Thr Leu Gly Glu Gly Gln Val Val Arg Val Lys 
    210                 215                 220                 


Tyr Gly Asn Ala Asp Gly Glu Tyr Cys Lys Phe Pro Phe Leu Phe Asn 
225                 230                 235                 240 


Gly Lys Glu Tyr Asn Ser Cys Thr Asp Thr Gly Arg Ser Asp Gly Phe 
                245                 250                 255     


Leu Trp Cys Ser Thr Thr Tyr Asn Phe Glu Lys Asp Gly Lys Tyr Gly 
            260                 265                 270         


Phe Cys Pro His Glu Ala Leu Phe Thr Met Gly Gly Asn Ala Glu Gly 
        275                 280                 285             


Gln Pro Cys Lys Phe Pro Phe Arg Phe Gln Gly Thr Ser Tyr Asp Ser 
    290                 295                 300                 


Cys Thr Thr Glu Gly Arg Thr Asp Gly Tyr Arg Trp Cys Gly Thr Thr 
305                 310                 315                 320 


Glu Asp Tyr Asp Arg Asp Lys Lys Tyr Gly Phe Cys Pro Glu Thr Ala 
                325                 330                 335     


Met Ser Thr Val Gly Gly Asn Ser Glu Gly Ala Pro Cys Val Phe Pro 
            340                 345                 350         


Phe Thr Phe Leu Gly Asn Lys Tyr Glu Ser Cys Thr Ser Ala Gly Arg 
        355                 360                 365             


Ser Asp Gly Lys Met Trp Cys Ala Thr Thr Ala Asn Tyr Asp Asp Asp 
    370                 375                 380                 


Arg Lys Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser Leu Phe Leu Val 
385                 390                 395                 400 


Ala Ala His Glu Phe Gly His Ala Met Gly Leu Glu His Ser Gln Asp 
                405                 410                 415     


Pro Gly Ala Leu Met Ala Pro Ile Tyr Thr Tyr Thr Lys Asn Phe Arg 
            420                 425                 430         


Leu Ser Gln Asp Asp Ile Lys Gly Ile Gln Glu Leu Tyr Gly Ala Ser 
        435                 440                 445             


Pro Asp Ile Asp Leu Gly Thr Gly Pro Thr Pro Thr Leu Gly Pro Val 
    450                 455                 460                 


Thr Pro Glu Ile Cys Lys Gln Asp Ile Val Phe Asp Gly Ile Ala Gln 
465                 470                 475                 480 


Ile Arg Gly Glu Ile Phe Phe Phe Lys Asp Arg Phe Ile Trp Arg Thr 
                485                 490                 495     


Val Thr Pro Arg Asp Lys Pro Met Gly Pro Leu Leu Val Ala Thr Phe 
            500                 505                 510         


Trp Pro Glu Leu Pro Glu Lys Ile Asp Ala Val Tyr Glu Ala Pro Gln 
        515                 520                 525             


Glu Glu Lys Ala Val Phe Phe Ala Gly Asn Glu Tyr Trp Ile Tyr Ser 
    530                 535                 540                 


Ala Ser Thr Leu Glu Arg Gly Tyr Pro Lys Pro Leu Thr Ser Leu Gly 
545                 550                 555                 560 


Leu Pro Pro Asp Val Gln Arg Val Asp Ala Ala Phe Asn Trp Ser Lys 
                565                 570                 575     


Asn Lys Lys Thr Tyr Ile Phe Ala Gly Asp Lys Phe Trp Arg Tyr Asn 
            580                 585                 590         


Glu Val Lys Lys Lys Met Asp Pro Gly Phe Pro Lys Leu Ile Ala Asp 
        595                 600                 605             


Ala Trp Asn Ala Ile Pro Asp Asn Leu Asp Ala Val Val Asp Leu Gln 
    610                 615                 620                 


Gly Gly Gly His Ser Tyr Phe Phe Lys Gly Ala Tyr Tyr Leu Lys Leu 
625                 630                 635                 640 


Glu Asn Gln Ser Leu Lys Ser Val Lys Phe Gly Ser Ile Lys Ser Asp 
                645                 650                 655     


Trp Leu Gly Cys 
            660 


<210>  8791
<211>  118
<212>  PRT
<213>  Homo Sapiens

<400>  8791

Met Gln Lys Phe Phe Gly Leu Pro Gln Thr Gly Asp Leu Asp Gln Asn 
1               5                   10                  15      


Thr Ile Glu Thr Met Arg Lys Pro Arg Cys Gly Asn Pro Asp Val Ala 
            20                  25                  30          


Asn Tyr Asn Phe Phe Pro Arg Lys Pro Lys Trp Asp Lys Asn Gln Ile 
        35                  40                  45              


Thr Tyr Arg Ile Ile Gly Tyr Thr Pro Asp Leu Asp Pro Glu Thr Val 
    50                  55                  60                  


Asp Asp Ala Phe Ala Arg Ala Phe Gln Val Trp Ser Asp Val Thr Pro 
65                  70                  75                  80  


Leu Arg Phe Ser Arg Ile His Asp Gly Glu Ala Asp Ile Met Ile Asn 
                85                  90                  95      


Phe Gly Arg Trp Glu His Gly Asp Gly Tyr Pro Phe Asp Gly Lys Asp 
            100                 105                 110         


Gly Leu Leu Ala His Ala 
        115             


<210>  8792
<211>  201
<212>  PRT
<213>  Homo Sapiens

<400>  8792

Met Gln Lys Phe Phe Gly Leu Pro Gln Thr Gly Asp Leu Asp Gln Asn 
1               5                   10                  15      


Thr Ile Glu Thr Met Arg Lys Pro Arg Cys Gly Asn Pro Asp Val Ala 
            20                  25                  30          


Asn Tyr Asn Phe Phe Pro Arg Lys Pro Lys Trp Asp Lys Asn Gln Ile 
        35                  40                  45              


Thr Tyr Arg Ile Ile Gly Tyr Thr Pro Asp Leu Asp Pro Glu Thr Val 
    50                  55                  60                  


Asp Asp Ala Phe Ala Arg Ala Phe Gln Val Trp Ser Asp Val Thr Pro 
65                  70                  75                  80  


Leu Arg Phe Ser Arg Ile His Asp Gly Glu Ala Asp Ile Met Ile Asn 
                85                  90                  95      


Phe Gly Arg Trp Glu His Gly Asp Gly Tyr Pro Phe Asp Gly Lys Asp 
            100                 105                 110         


Gly Leu Leu Ala His Ala Phe Ala Pro Gly Thr Gly Val Gly Gly Asp 
        115                 120                 125             


Ser His Phe Asp Asp Asp Glu Leu Trp Thr Leu Gly Glu Gly Gln Val 
    130                 135                 140                 


Val Arg Val Lys Tyr Gly Asn Ala Asp Gly Glu Tyr Cys Lys Phe Pro 
145                 150                 155                 160 


Phe Leu Phe Asn Gly Lys Glu Tyr Asn Ser Cys Thr Asp Thr Gly Arg 
                165                 170                 175     


Ser Asp Gly Phe Leu Trp Cys Ser Thr Thr Tyr Asn Phe Glu Lys Asp 
            180                 185                 190         


Gly Lys Tyr Gly Phe Cys Pro His Glu 
        195                 200     


<210>  8793
<211>  584
<212>  PRT
<213>  Homo Sapiens

<400>  8793

Met Gln Lys Phe Phe Gly Leu Pro Gln Thr Gly Asp Leu Asp Gln Asn 
1               5                   10                  15      


Thr Ile Glu Thr Met Arg Lys Pro Arg Cys Gly Asn Pro Asp Val Ala 
            20                  25                  30          


Asn Tyr Asn Phe Phe Pro Arg Lys Pro Lys Trp Asp Lys Asn Gln Ile 
        35                  40                  45              


Thr Tyr Arg Ile Ile Gly Tyr Thr Pro Asp Leu Asp Pro Glu Thr Val 
    50                  55                  60                  


Asp Asp Ala Phe Ala Arg Ala Phe Gln Val Trp Ser Asp Val Thr Pro 
65                  70                  75                  80  


Leu Arg Phe Ser Arg Ile His Asp Gly Glu Ala Asp Ile Met Ile Asn 
                85                  90                  95      


Phe Gly Arg Trp Glu His Gly Asp Gly Tyr Pro Phe Asp Gly Lys Asp 
            100                 105                 110         


Gly Leu Leu Ala His Ala Phe Ala Pro Gly Thr Gly Val Gly Gly Asp 
        115                 120                 125             


Ser His Phe Asp Asp Asp Glu Leu Trp Thr Leu Gly Glu Gly Gln Val 
    130                 135                 140                 


Val Arg Val Lys Tyr Gly Asn Ala Asp Gly Glu Tyr Cys Lys Phe Pro 
145                 150                 155                 160 


Phe Leu Phe Asn Gly Lys Glu Tyr Asn Ser Cys Thr Asp Thr Gly Arg 
                165                 170                 175     


Ser Asp Gly Phe Leu Trp Cys Ser Thr Thr Tyr Asn Phe Glu Lys Asp 
            180                 185                 190         


Gly Lys Tyr Gly Phe Cys Pro His Glu Ala Leu Phe Thr Met Gly Gly 
        195                 200                 205             


Asn Ala Glu Gly Gln Pro Cys Lys Phe Pro Phe Arg Phe Gln Gly Thr 
    210                 215                 220                 


Ser Tyr Asp Ser Cys Thr Thr Glu Gly Arg Thr Asp Gly Tyr Arg Trp 
225                 230                 235                 240 


Cys Gly Thr Thr Glu Asp Tyr Asp Arg Asp Lys Lys Tyr Gly Phe Cys 
                245                 250                 255     


Pro Glu Thr Ala Met Ser Thr Val Gly Gly Asn Ser Glu Gly Ala Pro 
            260                 265                 270         


Cys Val Phe Pro Phe Thr Phe Leu Gly Asn Lys Tyr Glu Ser Cys Thr 
        275                 280                 285             


Ser Ala Gly Arg Ser Asp Gly Lys Met Trp Cys Ala Thr Thr Ala Asn 
    290                 295                 300                 


Tyr Asp Asp Asp Arg Lys Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser 
305                 310                 315                 320 


Leu Phe Leu Val Ala Ala His Glu Phe Gly His Ala Met Gly Leu Glu 
                325                 330                 335     


His Ser Gln Asp Pro Gly Ala Leu Met Ala Pro Ile Tyr Thr Tyr Thr 
            340                 345                 350         


Lys Asn Phe Arg Leu Ser Gln Asp Asp Ile Lys Gly Ile Gln Glu Leu 
        355                 360                 365             


Tyr Gly Ala Ser Pro Asp Ile Asp Leu Gly Thr Gly Pro Thr Pro Thr 
    370                 375                 380                 


Leu Gly Pro Val Thr Pro Glu Ile Cys Lys Gln Asp Ile Val Phe Asp 
385                 390                 395                 400 


Gly Ile Ala Gln Ile Arg Gly Glu Ile Phe Phe Phe Lys Asp Arg Phe 
                405                 410                 415     


Ile Trp Arg Thr Val Thr Pro Arg Asp Lys Pro Met Gly Pro Leu Leu 
            420                 425                 430         


Val Ala Thr Phe Trp Pro Glu Leu Pro Glu Lys Ile Asp Ala Val Tyr 
        435                 440                 445             


Glu Ala Pro Gln Glu Glu Lys Ala Val Phe Phe Ala Gly Asn Glu Tyr 
    450                 455                 460                 


Trp Ile Tyr Ser Ala Ser Thr Leu Glu Arg Gly Tyr Pro Lys Pro Leu 
465                 470                 475                 480 


Thr Ser Leu Gly Leu Pro Pro Asp Val Gln Arg Val Asp Ala Ala Phe 
                485                 490                 495     


Asn Trp Ser Lys Asn Lys Lys Thr Tyr Ile Phe Ala Gly Asp Lys Phe 
            500                 505                 510         


Trp Arg Tyr Asn Glu Val Lys Lys Lys Met Asp Pro Gly Phe Pro Lys 
        515                 520                 525             


Leu Ile Ala Asp Ala Trp Asn Ala Ile Pro Asp Asn Leu Asp Ala Val 
    530                 535                 540                 


Val Asp Leu Gln Gly Gly Gly His Ser Tyr Phe Phe Lys Gly Ala Tyr 
545                 550                 555                 560 


Tyr Leu Lys Leu Glu Asn Gln Ser Leu Lys Ser Val Lys Phe Gly Ser 
                565                 570                 575     


Ile Lys Ser Asp Trp Leu Gly Cys 
            580                 


<210>  8794
<211>  584
<212>  PRT
<213>  Homo Sapiens

<400>  8794

Met Gln Lys Phe Phe Gly Leu Pro Gln Thr Gly Asp Leu Asp Gln Asn 
1               5                   10                  15      


Thr Ile Glu Thr Met Arg Lys Pro Arg Cys Gly Asn Pro Asp Val Ala 
            20                  25                  30          


Asn Tyr Asn Phe Phe Pro Arg Lys Pro Lys Trp Asp Lys Asn Gln Ile 
        35                  40                  45              


Thr Tyr Arg Ile Ile Gly Tyr Thr Pro Asp Leu Asp Pro Glu Thr Val 
    50                  55                  60                  


Asp Asp Ala Phe Ala Arg Ala Phe Gln Val Trp Ser Asp Val Thr Pro 
65                  70                  75                  80  


Leu Arg Phe Ser Arg Ile His Asp Gly Glu Ala Asp Ile Met Ile Asn 
                85                  90                  95      


Phe Gly Arg Trp Glu His Gly Asp Gly Tyr Pro Phe Asp Gly Lys Asp 
            100                 105                 110         


Gly Leu Leu Ala His Ala Phe Ala Pro Gly Thr Gly Val Gly Gly Asp 
        115                 120                 125             


Ser His Phe Asp Asp Asp Glu Leu Trp Thr Leu Gly Glu Gly Gln Val 
    130                 135                 140                 


Val Arg Val Lys Tyr Gly Asn Ala Asp Gly Glu Tyr Cys Lys Phe Pro 
145                 150                 155                 160 


Phe Leu Phe Asn Gly Lys Glu Tyr Asn Ser Cys Thr Asp Thr Gly Arg 
                165                 170                 175     


Ser Asp Gly Phe Leu Trp Cys Ser Thr Thr Tyr Asn Phe Glu Lys Asp 
            180                 185                 190         


Gly Lys Tyr Gly Phe Cys Pro His Glu Ala Leu Phe Thr Met Gly Gly 
        195                 200                 205             


Asn Ala Glu Gly Gln Pro Cys Lys Phe Pro Phe Arg Phe Gln Gly Thr 
    210                 215                 220                 


Ser Tyr Asp Ser Cys Thr Thr Glu Gly Arg Thr Asp Gly Tyr Arg Trp 
225                 230                 235                 240 


Cys Gly Thr Thr Glu Asp Tyr Asp Arg Asp Lys Lys Tyr Gly Phe Cys 
                245                 250                 255     


Pro Glu Thr Ala Met Ser Thr Val Gly Gly Asn Ser Glu Gly Ala Pro 
            260                 265                 270         


Cys Val Phe Pro Phe Thr Phe Leu Gly Asn Lys Tyr Glu Ser Cys Thr 
        275                 280                 285             


Ser Ala Gly Arg Ser Asp Gly Lys Met Trp Cys Ala Thr Thr Ala Asn 
    290                 295                 300                 


Tyr Asp Asp Asp Arg Lys Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser 
305                 310                 315                 320 


Leu Phe Leu Val Ala Ala His Glu Phe Gly His Ala Met Gly Leu Glu 
                325                 330                 335     


His Ser Gln Asp Pro Gly Ala Leu Met Ala Pro Ile Tyr Thr Tyr Thr 
            340                 345                 350         


Lys Asn Phe Arg Leu Ser Gln Asp Asp Ile Lys Gly Ile Gln Glu Leu 
        355                 360                 365             


Tyr Gly Ala Ser Pro Asp Ile Asp Leu Gly Thr Gly Pro Thr Pro Thr 
    370                 375                 380                 


Leu Gly Pro Val Thr Pro Glu Ile Cys Lys Gln Asp Ile Val Phe Asp 
385                 390                 395                 400 


Gly Ile Ala Gln Ile Arg Gly Glu Ile Phe Phe Phe Lys Asp Arg Phe 
                405                 410                 415     


Ile Trp Arg Thr Val Thr Pro Arg Asp Lys Pro Met Gly Pro Leu Leu 
            420                 425                 430         


Val Ala Thr Phe Trp Pro Glu Leu Pro Glu Lys Ile Asp Ala Val Tyr 
        435                 440                 445             


Glu Ala Pro Gln Glu Glu Lys Ala Val Phe Phe Ala Gly Asn Glu Tyr 
    450                 455                 460                 


Trp Ile Tyr Ser Ala Ser Thr Leu Glu Arg Gly Tyr Pro Lys Pro Leu 
465                 470                 475                 480 


Thr Ser Leu Gly Leu Pro Pro Asp Val Gln Arg Val Asp Ala Ala Phe 
                485                 490                 495     


Asn Trp Ser Lys Asn Lys Lys Thr Tyr Ile Phe Ala Gly Asp Lys Phe 
            500                 505                 510         


Trp Arg Tyr Asn Glu Val Lys Lys Lys Met Asp Pro Gly Phe Pro Lys 
        515                 520                 525             


Leu Ile Ala Asp Ala Trp Asn Ala Ile Pro Asp Asn Leu Asp Ala Val 
    530                 535                 540                 


Val Asp Leu Gln Gly Gly Gly His Ser Tyr Phe Phe Lys Gly Ala Tyr 
545                 550                 555                 560 


Tyr Leu Lys Leu Glu Asn Gln Ser Leu Lys Ser Val Lys Phe Gly Ser 
                565                 570                 575     


Ile Lys Ser Asp Trp Leu Gly Cys 
            580                 


<210>  8795
<211>  610
<212>  PRT
<213>  Homo Sapiens

<400>  8795

Met Gln Tyr Leu Asn Thr Phe Tyr Gly Cys Pro Lys Glu Ser Cys Asn 
1               5                   10                  15      


Leu Phe Val Leu Lys Asp Thr Leu Lys Lys Met Gln Lys Phe Phe Gly 
            20                  25                  30          


Leu Pro Gln Thr Gly Asp Leu Asp Gln Asn Thr Ile Glu Thr Met Arg 
        35                  40                  45              


Lys Pro Arg Cys Gly Asn Pro Asp Val Ala Asn Tyr Asn Phe Phe Pro 
    50                  55                  60                  


Arg Lys Pro Lys Trp Asp Lys Asn Gln Ile Thr Tyr Arg Ile Ile Gly 
65                  70                  75                  80  


Tyr Thr Pro Asp Leu Asp Pro Glu Thr Val Asp Asp Ala Phe Ala Arg 
                85                  90                  95      


Ala Phe Gln Val Trp Ser Asp Val Thr Pro Leu Arg Phe Ser Arg Ile 
            100                 105                 110         


His Asp Gly Glu Ala Asp Ile Met Ile Asn Phe Gly Arg Trp Glu His 
        115                 120                 125             


Gly Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly Leu Leu Ala His Ala 
    130                 135                 140                 


Phe Ala Pro Gly Thr Gly Val Gly Gly Asp Ser His Phe Asp Asp Asp 
145                 150                 155                 160 


Glu Leu Trp Thr Leu Gly Glu Gly Gln Val Val Arg Val Lys Tyr Gly 
                165                 170                 175     


Asn Ala Asp Gly Glu Tyr Cys Lys Phe Pro Phe Leu Phe Asn Gly Lys 
            180                 185                 190         


Glu Tyr Asn Ser Cys Thr Asp Thr Gly Arg Ser Asp Gly Phe Leu Trp 
        195                 200                 205             


Cys Ser Thr Thr Tyr Asn Phe Glu Lys Asp Gly Lys Tyr Gly Phe Cys 
    210                 215                 220                 


Pro His Glu Ala Leu Phe Thr Met Gly Gly Asn Ala Glu Gly Gln Pro 
225                 230                 235                 240 


Cys Lys Phe Pro Phe Arg Phe Gln Gly Thr Ser Tyr Asp Ser Cys Thr 
                245                 250                 255     


Thr Glu Gly Arg Thr Asp Gly Tyr Arg Trp Cys Gly Thr Thr Glu Asp 
            260                 265                 270         


Tyr Asp Arg Asp Lys Lys Tyr Gly Phe Cys Pro Glu Thr Ala Met Ser 
        275                 280                 285             


Thr Val Gly Gly Asn Ser Glu Gly Ala Pro Cys Val Phe Pro Phe Thr 
    290                 295                 300                 


Phe Leu Gly Asn Lys Tyr Glu Ser Cys Thr Ser Ala Gly Arg Ser Asp 
305                 310                 315                 320 


Gly Lys Met Trp Cys Ala Thr Thr Ala Asn Tyr Asp Asp Asp Arg Lys 
                325                 330                 335     


Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser Leu Phe Leu Val Ala Ala 
            340                 345                 350         


His Glu Phe Gly His Ala Met Gly Leu Glu His Ser Gln Asp Pro Gly 
        355                 360                 365             


Ala Leu Met Ala Pro Ile Tyr Thr Tyr Thr Lys Asn Phe Arg Leu Ser 
    370                 375                 380                 


Gln Asp Asp Ile Lys Gly Ile Gln Glu Leu Tyr Gly Ala Ser Pro Asp 
385                 390                 395                 400 


Ile Asp Leu Gly Thr Gly Pro Thr Pro Thr Leu Gly Pro Val Thr Pro 
                405                 410                 415     


Glu Ile Cys Lys Gln Asp Ile Val Phe Asp Gly Ile Ala Gln Ile Arg 
            420                 425                 430         


Gly Glu Ile Phe Phe Phe Lys Asp Arg Phe Ile Trp Arg Thr Val Thr 
        435                 440                 445             


Pro Arg Asp Lys Pro Met Gly Pro Leu Leu Val Ala Thr Phe Trp Pro 
    450                 455                 460                 


Glu Leu Pro Glu Lys Ile Asp Ala Val Tyr Glu Ala Pro Gln Glu Glu 
465                 470                 475                 480 


Lys Ala Val Phe Phe Ala Gly Asn Glu Tyr Trp Ile Tyr Ser Ala Ser 
                485                 490                 495     


Thr Leu Glu Arg Gly Tyr Pro Lys Pro Leu Thr Ser Leu Gly Leu Pro 
            500                 505                 510         


Pro Asp Val Gln Arg Val Asp Ala Ala Phe Asn Trp Ser Lys Asn Lys 
        515                 520                 525             


Lys Thr Tyr Ile Phe Ala Gly Asp Lys Phe Trp Arg Tyr Asn Glu Val 
    530                 535                 540                 


Lys Lys Lys Met Asp Pro Gly Phe Pro Lys Leu Ile Ala Asp Ala Trp 
545                 550                 555                 560 


Asn Ala Ile Pro Asp Asn Leu Asp Ala Val Val Asp Leu Gln Gly Gly 
                565                 570                 575     


Gly His Ser Tyr Phe Phe Lys Gly Ala Tyr Tyr Leu Lys Leu Glu Asn 
            580                 585                 590         


Gln Ser Leu Lys Ser Val Lys Phe Gly Ser Ile Lys Ser Asp Trp Leu 
        595                 600                 605             


Gly Cys 
    610 


<210>  8796
<211>  22
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8796

Xaa Leu Glu Asn Gln Ser Leu Lys Ser Val Lys Phe Gly Ser Ile Lys 
1               5                   10                  15      


Ser Asp Trp Leu Gly Cys 
            20          


<210>  8797
<211>  483
<212>  PRT
<213>  Homo Sapiens

<400>  8797

Met Lys Val Leu Pro Ala Ser Gly Leu Ala Val Phe Leu Ile Met Ala 
1               5                   10                  15      


Leu Lys Phe Ser Thr Ala Ala Pro Ser Leu Val Ala Ala Ser Pro Arg 
            20                  25                  30          


Thr Trp Arg Asn Asn Tyr Arg Leu Ala Gln Ala Tyr Leu Asp Lys Tyr 
        35                  40                  45              


Tyr Thr Asn Lys Glu Gly His Gln Ile Gly Glu Met Val Ala Arg Gly 
    50                  55                  60                  


Ser Asn Ser Met Ile Arg Lys Ile Lys Glu Leu Gln Ala Phe Phe Gly 
65                  70                  75                  80  


Leu Gln Val Thr Gly Lys Leu Asp Gln Thr Thr Met Asn Val Ile Lys 
                85                  90                  95      


Lys Pro Arg Cys Gly Val Pro Asp Val Ala Asn Tyr Arg Leu Phe Pro 
            100                 105                 110         


Gly Glu Pro Lys Trp Lys Lys Asn Thr Leu Thr Tyr Arg Ile Ser Lys 
        115                 120                 125             


Tyr Thr Pro Ser Met Ser Ser Val Glu Val Asp Lys Ala Val Glu Met 
    130                 135                 140                 


Ala Leu Gln Ala Trp Ser Ser Ala Val Pro Leu Ser Phe Val Arg Ile 
145                 150                 155                 160 


Asn Ser Gly Glu Ala Asp Ile Met Ile Ser Phe Glu Asn Gly Asp His 
                165                 170                 175     


Gly Asp Ser Tyr Pro Phe Asp Gly Pro Arg Gly Thr Leu Ala His Ala 
            180                 185                 190         


Phe Ala Pro Gly Glu Gly Leu Gly Gly Asp Thr His Phe Asp Asn Ala 
        195                 200                 205             


Glu Lys Trp Thr Met Gly Thr Asn Gly Phe Asn Leu Phe Thr Val Ala 
    210                 215                 220                 


Ala His Glu Phe Gly His Ala Leu Gly Leu Ala His Ser Thr Asp Pro 
225                 230                 235                 240 


Ser Ala Leu Met Tyr Pro Thr Tyr Lys Tyr Lys Asn Pro Tyr Gly Phe 
                245                 250                 255     


His Leu Pro Lys Asp Asp Val Lys Gly Ile Gln Ala Leu Tyr Gly Pro 
            260                 265                 270         


Arg Lys Val Phe Leu Gly Lys Pro Thr Leu Pro His Ala Pro His His 
        275                 280                 285             


Lys Pro Ser Ile Pro Asp Leu Cys Asp Ser Ser Ser Ser Phe Asp Ala 
    290                 295                 300                 


Val Thr Met Leu Gly Lys Glu Leu Leu Leu Phe Lys Asp Arg Ile Phe 
305                 310                 315                 320 


Trp Arg Arg Gln Val His Leu Arg Thr Gly Ile Arg Pro Ser Thr Ile 
                325                 330                 335     


Thr Ser Ser Phe Pro Gln Leu Met Ser Asn Val Asp Ala Ala Tyr Glu 
            340                 345                 350         


Val Ala Glu Arg Gly Thr Ala Tyr Phe Phe Lys Gly Pro His Tyr Trp 
        355                 360                 365             


Ile Thr Arg Gly Phe Gln Met Gln Gly Pro Pro Arg Thr Ile Tyr Asp 
    370                 375                 380                 


Phe Gly Phe Pro Arg His Val Gln Gln Ile Asp Ala Ala Val Tyr Leu 
385                 390                 395                 400 


Arg Glu Pro Gln Lys Thr Leu Phe Phe Val Gly Asp Glu Tyr Tyr Ser 
                405                 410                 415     


Tyr Asp Glu Arg Lys Arg Lys Met Glu Lys Asp Tyr Pro Lys Asn Thr 
            420                 425                 430         


Glu Glu Glu Phe Ser Gly Val Asn Gly Gln Ile Asp Ala Ala Val Glu 
        435                 440                 445             


Leu Asn Gly Tyr Ile Tyr Phe Phe Ser Gly Pro Lys Thr Tyr Lys Tyr 
    450                 455                 460                 


Asp Thr Glu Lys Glu Asp Val Val Ser Val Val Lys Ser Ser Ser Trp 
465                 470                 475                 480 


Ile Gly Cys 
            


<210>  8798
<211>  569
<212>  PRT
<213>  Homo Sapiens

<400>  8798

Met Leu Ala Ala Ser Ile Phe Arg Pro Thr Leu Leu Leu Cys Trp Leu 
1               5                   10                  15      


Ala Ala Pro Trp Pro Thr Gln Pro Glu Ser Leu Phe His Ser Arg Asp 
            20                  25                  30          


Arg Ser Asp Leu Glu Pro Ser Pro Leu Arg Gln Ala Lys Pro Ile Ala 
        35                  40                  45              


Asp Leu His Ala Ala Gln Arg Phe Leu Ser Arg Tyr Gly Trp Ser Gly 
    50                  55                  60                  


Val Trp Ala Ala Trp Gly Pro Ser Pro Glu Gly Pro Pro Glu Thr Pro 
65                  70                  75                  80  


Lys Gly Ala Ala Leu Ala Glu Ala Val Arg Arg Phe Gln Arg Ala Asn 
                85                  90                  95      


Ala Leu Pro Ala Ser Gly Glu Leu Asp Ala Ala Thr Leu Ala Ala Met 
            100                 105                 110         


Asn Arg Pro Arg Cys Gly Val Pro Asp Met Arg Pro Pro Pro Pro Ser 
        115                 120                 125             


Ala Pro Pro Ser Pro Pro Gly Pro Pro Pro Arg Ala Arg Ser Arg Arg 
    130                 135                 140                 


Ser Pro Arg Ala Pro Leu Ser Leu Ser Arg Arg Gly Trp Gln Pro Arg 
145                 150                 155                 160 


Gly Tyr Pro Asp Gly Gly Ala Ala Gln Ala Phe Ser Lys Arg Thr Leu 
                165                 170                 175     


Ser Trp Arg Leu Leu Gly Glu Ala Leu Ser Ser Gln Leu Ser Val Ala 
            180                 185                 190         


Asp Gln Arg Arg Ile Val Ala Leu Ala Phe Arg Met Trp Ser Glu Val 
        195                 200                 205             


Thr Pro Leu Asp Phe Arg Glu Asp Leu Ala Ala Pro Gly Ala Ala Val 
    210                 215                 220                 


Asp Ile Lys Leu Gly Phe Gly Arg Gly Arg His Leu Gly Cys Pro Arg 
225                 230                 235                 240 


Ala Phe Asp Gly Ser Gly Gln Glu Phe Ala His Ala Trp Arg Leu Gly 
                245                 250                 255     


Asp Ile His Phe Asp Asp Asp Glu His Phe Thr Pro Pro Thr Ser Asp 
            260                 265                 270         


Thr Gly Ile Ser Leu Leu Lys Val Ala Val His Glu Ile Gly His Val 
        275                 280                 285             


Leu Gly Leu Pro His Thr Tyr Arg Thr Gly Ser Ile Met Gln Pro Asn 
    290                 295                 300                 


Tyr Ile Pro Gln Glu Pro Ala Phe Glu Leu Asp Trp Ser Asp Arg Lys 
305                 310                 315                 320 


Ala Ile Gln Lys Leu Tyr Gly Ser Cys Glu Gly Ser Phe Asp Thr Ala 
                325                 330                 335     


Phe Asp Trp Ile Arg Lys Glu Arg Asn Gln Tyr Gly Glu Val Met Val 
            340                 345                 350         


Arg Phe Ser Thr Tyr Phe Phe Arg Asn Ser Trp Tyr Trp Leu Tyr Glu 
        355                 360                 365             


Asn Arg Asn Asn Arg Thr Arg Tyr Gly Asp Pro Ile Gln Ile Leu Thr 
    370                 375                 380                 


Gly Trp Pro Gly Ile Pro Thr His Asn Ile Asp Ala Phe Val His Ile 
385                 390                 395                 400 


Trp Thr Trp Lys Arg Asp Glu Arg Tyr Phe Phe Gln Gly Asn Gln Tyr 
                405                 410                 415     


Trp Arg Tyr Asp Ser Asp Lys Asp Gln Ala Leu Thr Glu Asp Glu Gln 
            420                 425                 430         


Gly Lys Ser Tyr Pro Lys Leu Ile Ser Glu Gly Phe Pro Gly Ile Pro 
        435                 440                 445             


Ser Pro Leu Asp Thr Ala Phe Tyr Asp Arg Arg Gln Lys Leu Ile Tyr 
    450                 455                 460                 


Phe Phe Lys Glu Ser Leu Val Phe Ala Phe Asp Val Asn Arg Asn Arg 
465                 470                 475                 480 


Val Leu Asn Ser Tyr Pro Lys Arg Ile Thr Glu Val Phe Pro Ala Val 
                485                 490                 495     


Ile Pro Gln Asn His Pro Phe Arg Asn Ile Asp Ser Ala Tyr Tyr Ser 
            500                 505                 510         


Tyr Ala Tyr Asn Ser Ile Phe Phe Phe Lys Gly Asn Ala Tyr Trp Lys 
        515                 520                 525             


Val Val Asn Asp Lys Asp Lys Gln Gln Asn Ser Trp Leu Pro Ala Asn 
    530                 535                 540                 


Gly Leu Phe Pro Lys Lys Phe Ile Ser Glu Lys Trp Phe Asp Val Cys 
545                 550                 555                 560 


Asp Val His Ile Ser Thr Leu Asn Met 
                565                 


<210>  8799
<211>  183
<212>  PRT
<213>  Homo Sapiens

<400>  8799

Met Asp Pro Gly Thr Val Ala Thr Met Arg Lys Pro Arg Cys Ser Leu 
1               5                   10                  15      


Pro Asp Val Leu Gly Val Ala Gly Leu Val Arg Arg Arg Arg Arg Tyr 
            20                  25                  30          


Ala Leu Ser Gly Ser Val Trp Lys Lys Arg Thr Leu Thr Trp Arg Val 
        35                  40                  45              


Arg Ser Phe Pro Gln Ser Ser Gln Leu Ser Gln Glu Thr Val Arg Val 
    50                  55                  60                  


Leu Met Ser Tyr Ala Leu Met Ala Trp Gly Met Glu Ser Gly Leu Thr 
65                  70                  75                  80  


Phe His Glu Val Asp Ser Pro Gln Gly Gln Glu Pro Asp Ile Leu Ile 
                85                  90                  95      


Asp Phe Ala Arg Ala Phe His Gln Asp Ser Tyr Pro Phe Asp Gly Leu 
            100                 105                 110         


Gly Gly Thr Leu Ala His Ala Phe Phe Pro Gly Glu His Pro Ile Ser 
        115                 120                 125             


Gly Asp Thr His Phe Asp Asp Glu Glu Thr Trp Thr Phe Gly Ser Lys 
    130                 135                 140                 


Ala Ser Gln Gln Leu Glu Gln Glu Leu Ala Gly Gly Ser Pro Val Asp 
145                 150                 155                 160 


Glu Glu Leu Gly Phe Ser Arg Gly Trp Arg Val Asn Pro Leu Gly Pro 
                165                 170                 175     


Gly Ser Pro Glu Arg Leu Ser 
            180             


<210>  8800
<211>  562
<212>  PRT
<213>  Homo Sapiens

<400>  8800

Met Arg Leu Arg Leu Arg Leu Leu Ala Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Pro Pro Ala Arg Ala Pro Lys Pro Ser Ala Gln Asp Val Ser Leu Gly 
            20                  25                  30          


Val Asp Trp Leu Thr Arg Tyr Gly Tyr Leu Pro Pro Pro His Pro Ala 
        35                  40                  45              


Gln Ala Gln Leu Gln Ser Pro Glu Lys Leu Arg Asp Ala Ile Lys Val 
    50                  55                  60                  


Met Gln Arg Phe Ala Gly Leu Pro Glu Thr Gly Arg Met Asp Pro Gly 
65                  70                  75                  80  


Thr Val Ala Thr Met Arg Lys Pro Arg Cys Ser Leu Pro Asp Val Leu 
                85                  90                  95      


Gly Val Ala Gly Leu Val Arg Arg Arg Arg Arg Tyr Ala Leu Ser Gly 
            100                 105                 110         


Ser Val Trp Lys Lys Arg Thr Leu Thr Trp Arg Val Arg Ser Phe Pro 
        115                 120                 125             


Gln Ser Ser Gln Leu Ser Gln Glu Thr Val Arg Val Leu Met Ser Tyr 
    130                 135                 140                 


Ala Leu Met Ala Trp Gly Met Glu Ser Gly Leu Thr Phe His Glu Val 
145                 150                 155                 160 


Asp Ser Pro Gln Gly Gln Glu Pro Asp Ile Leu Ile Asp Phe Ala Arg 
                165                 170                 175     


Ala Phe His Gln Asp Ser Tyr Pro Phe Asp Gly Leu Gly Gly Thr Leu 
            180                 185                 190         


Ala His Ala Phe Phe Pro Gly Glu His Pro Ile Ser Gly Asp Thr His 
        195                 200                 205             


Phe Asp Asp Glu Glu Thr Trp Thr Phe Gly Ser Lys Asp Gly Glu Gly 
    210                 215                 220                 


Thr Asp Leu Phe Ala Val Ala Val His Glu Phe Gly His Ala Leu Gly 
225                 230                 235                 240 


Leu Gly His Ser Ser Ala Pro Asn Ser Ile Met Arg Pro Phe Tyr Gln 
                245                 250                 255     


Gly Pro Val Gly Asp Pro Asp Lys Tyr Arg Leu Ser Gln Asp Asp Arg 
            260                 265                 270         


Asp Gly Leu Gln Gln Leu Tyr Gly Lys Ala Pro Gln Thr Pro Tyr Asp 
        275                 280                 285             


Lys Pro Thr Arg Lys Pro Leu Ala Pro Pro Pro Gln Pro Pro Ala Ser 
    290                 295                 300                 


Pro Thr His Ser Pro Ser Phe Pro Ile Pro Asp Arg Cys Glu Gly Asn 
305                 310                 315                 320 


Phe Asp Ala Ile Ala Asn Ile Arg Gly Glu Thr Phe Phe Phe Lys Gly 
                325                 330                 335     


Pro Trp Phe Trp Arg Leu Gln Pro Ser Gly Gln Leu Val Ser Pro Arg 
            340                 345                 350         


Pro Ala Arg Leu His Arg Phe Trp Glu Gly Leu Pro Ala Gln Val Arg 
        355                 360                 365             


Val Val Gln Ala Ala Tyr Ala Arg His Arg Asp Gly Arg Ile Leu Leu 
    370                 375                 380                 


Phe Ser Gly Pro Gln Phe Trp Val Phe Gln Asp Arg Gln Leu Glu Gly 
385                 390                 395                 400 


Gly Ala Arg Pro Leu Thr Glu Leu Gly Leu Pro Pro Gly Glu Glu Val 
                405                 410                 415     


Asp Ala Val Phe Ser Trp Pro Gln Asn Gly Lys Thr Tyr Leu Val Arg 
            420                 425                 430         


Gly Arg Gln Tyr Trp Arg Tyr Asp Glu Ala Ala Ala Arg Pro Asp Pro 
        435                 440                 445             


Gly Tyr Pro Arg Asp Leu Ser Leu Trp Glu Gly Ala Pro Pro Ser Pro 
    450                 455                 460                 


Asp Asp Val Thr Val Ser Asn Ala Gly Asp Thr Tyr Phe Phe Lys Gly 
465                 470                 475                 480 


Ala His Tyr Trp Arg Phe Pro Lys Asn Ser Ile Lys Thr Glu Pro Asp 
                485                 490                 495     


Ala Pro Gln Pro Met Gly Pro Asn Trp Leu Asp Cys Pro Ala Pro Ser 
            500                 505                 510         


Ser Gly Pro Arg Ala Pro Arg Pro Pro Lys Ala Thr Pro Val Ser Glu 
        515                 520                 525             


Thr Cys Asp Cys Gln Cys Glu Leu Asn Gln Ala Ala Gly Arg Trp Pro 
    530                 535                 540                 


Ala Pro Ile Pro Leu Leu Leu Leu Pro Leu Leu Val Gly Gly Val Ala 
545                 550                 555                 560 


Ser Arg 
        


<210>  8801
<211>  261
<212>  PRT
<213>  Homo Sapiens

<400>  8801

Met Gln Leu Val Ile Leu Arg Val Thr Ile Phe Leu Pro Trp Cys Phe 
1               5                   10                  15      


Ala Val Pro Val Pro Pro Ala Ala Asp His Lys Gly Trp Asp Phe Val 
            20                  25                  30          


Glu Gly Tyr Phe His Gln Phe Phe Leu Thr Lys Lys Glu Ser Pro Leu 
        35                  40                  45              


Leu Thr Gln Glu Thr Gln Thr Gln Leu Leu Gln Gln Phe His Arg Asn 
    50                  55                  60                  


Gly Thr Asp Leu Leu Asp Met Gln Met His Ala Leu Leu His Gln Pro 
65                  70                  75                  80  


His Cys Gly Val Pro Asp Gly Ser Asp Thr Ser Ile Ser Pro Gly Arg 
                85                  90                  95      


Cys Lys Trp Asn Lys His Thr Leu Thr Tyr Arg Ile Ile Asn Tyr Pro 
            100                 105                 110         


His Asp Met Lys Pro Ser Ala Val Lys Asp Ser Ile Tyr Asn Ala Val 
        115                 120                 125             


Ser Ile Trp Ser Asn Val Thr Pro Leu Ile Phe Gln Gln Val Gln Asn 
    130                 135                 140                 


Gly Asp Ala Asp Ile Lys Val Ser Phe Trp Gln Trp Ala His Glu Asp 
145                 150                 155                 160 


Gly Trp Pro Phe Asp Gly Pro Gly Gly Ile Leu Gly His Ala Phe Leu 
                165                 170                 175     


Pro Asn Ser Gly Asn Pro Gly Val Val His Phe Asp Lys Asn Glu His 
            180                 185                 190         


Trp Ser Ala Ser Asp Thr Gly Tyr Asn Leu Phe Leu Val Ala Thr His 
        195                 200                 205             


Glu Ile Gly His Ser Leu Gly Leu Gln His Ser Gly Asn Gln Ser Ser 
    210                 215                 220                 


Ile Met Tyr Pro Thr Tyr Trp Tyr His Asp Pro Arg Thr Phe Gln Leu 
225                 230                 235                 240 


Ser Ala Asp Asp Ile Gln Arg Ile Gln His Leu Tyr Gly Glu Lys Cys 
                245                 250                 255     


Ser Ser Asp Ile Pro 
            260     


<210>  8802
<211>  261
<212>  PRT
<213>  Homo Sapiens

<400>  8802

Met Gln Leu Val Ile Leu Arg Val Thr Ile Phe Leu Pro Trp Cys Phe 
1               5                   10                  15      


Ala Val Pro Val Pro Pro Ala Ala Asp His Lys Gly Trp Asp Phe Val 
            20                  25                  30          


Glu Gly Tyr Phe His Gln Phe Phe Leu Thr Lys Lys Glu Ser Pro Leu 
        35                  40                  45              


Leu Thr Gln Glu Thr Gln Thr Gln Leu Leu Gln Gln Phe His Arg Asn 
    50                  55                  60                  


Gly Thr Asp Leu Leu Asp Met Gln Met His Ala Leu Leu His Gln Pro 
65                  70                  75                  80  


His Cys Gly Val Pro Asp Gly Ser Asp Thr Ser Ile Ser Pro Gly Arg 
                85                  90                  95      


Cys Lys Trp Asn Lys His Thr Leu Thr Tyr Arg Ile Ile Asn Tyr Pro 
            100                 105                 110         


His Asp Met Lys Pro Ser Ala Val Lys Asp Ser Ile Tyr Asn Ala Val 
        115                 120                 125             


Ser Ile Trp Ser Asn Val Thr Pro Leu Ile Phe Gln Gln Val Gln Asn 
    130                 135                 140                 


Gly Asp Ala Asp Ile Lys Val Ser Phe Trp Gln Trp Ala His Glu Asp 
145                 150                 155                 160 


Gly Trp Pro Phe Asp Gly Pro Gly Gly Ile Leu Gly His Ala Phe Leu 
                165                 170                 175     


Pro Asn Ser Gly Asn Pro Gly Val Val His Phe Asp Lys Asn Glu His 
            180                 185                 190         


Trp Ser Ala Ser Asp Thr Gly Tyr Asn Leu Phe Leu Val Ala Thr His 
        195                 200                 205             


Glu Ile Gly His Ser Leu Gly Leu Gln His Ser Gly Asn Gln Ser Ser 
    210                 215                 220                 


Ile Met Tyr Pro Thr Tyr Trp Tyr His Asp Pro Arg Thr Phe Gln Leu 
225                 230                 235                 240 


Ser Ala Asp Asp Ile Gln Arg Ile Gln His Leu Tyr Gly Glu Lys Cys 
                245                 250                 255     


Ser Ser Asp Ile Pro 
            260     


<210>  8803
<211>  513
<212>  PRT
<213>  Homo Sapiens

<400>  8803

Met Lys Arg Leu Leu Leu Leu Phe Leu Phe Phe Ile Thr Phe Ser Ser 
1               5                   10                  15      


Ala Phe Pro Leu Val Arg Met Thr Glu Asn Glu Glu Asn Met Gln Leu 
            20                  25                  30          


Ala Gln Ala Tyr Leu Asn Gln Phe Tyr Ser Leu Glu Ile Glu Gly Asn 
        35                  40                  45              


His Leu Val Gln Ser Lys Asn Arg Ser Leu Ile Asp Asp Lys Ile Arg 
    50                  55                  60                  


Glu Met Gln Ala Phe Phe Gly Leu Thr Val Thr Gly Lys Leu Asp Ser 
65                  70                  75                  80  


Asn Thr Leu Glu Ile Met Lys Thr Pro Arg Cys Gly Val Pro Asp Val 
                85                  90                  95      


Gly Gln Tyr Gly Tyr Thr Leu Pro Gly Trp Arg Lys Tyr Asn Leu Thr 
            100                 105                 110         


Tyr Arg Ile Ile Asn Tyr Thr Pro Asp Met Ala Arg Ala Ala Val Asp 
        115                 120                 125             


Glu Ala Ile Gln Glu Gly Leu Glu Val Trp Ser Lys Val Thr Pro Leu 
    130                 135                 140                 


Lys Phe Thr Lys Ile Ser Lys Gly Ile Ala Asp Ile Met Ile Ala Phe 
145                 150                 155                 160 


Arg Thr Arg Val His Gly Arg Cys Pro Arg Tyr Phe Asp Gly Pro Leu 
                165                 170                 175     


Gly Val Leu Gly His Ala Phe Pro Pro Gly Pro Gly Leu Gly Gly Asp 
            180                 185                 190         


Thr His Phe Asp Glu Asp Glu Asn Trp Thr Lys Asp Gly Ala Gly Phe 
        195                 200                 205             


Asn Leu Phe Leu Val Ala Ala His Glu Phe Gly His Ala Leu Gly Leu 
    210                 215                 220                 


Ser His Ser Asn Asp Gln Thr Ala Leu Met Phe Pro Asn Tyr Val Ser 
225                 230                 235                 240 


Leu Asp Pro Arg Lys Tyr Pro Leu Ser Gln Asp Asp Ile Asn Gly Ile 
                245                 250                 255     


Gln Ser Ile Tyr Gly Gly Leu Pro Lys Glu Pro Ala Lys Pro Lys Glu 
            260                 265                 270         


Pro Thr Ile Pro His Ala Cys Asp Pro Asp Leu Thr Phe Asp Ala Ile 
        275                 280                 285             


Thr Thr Phe Arg Arg Glu Val Met Phe Phe Lys Gly Arg His Leu Trp 
    290                 295                 300                 


Arg Ile Tyr Tyr Asp Ile Thr Asp Val Glu Phe Glu Leu Ile Ala Ser 
305                 310                 315                 320 


Phe Trp Pro Ser Leu Pro Ala Asp Leu Gln Ala Ala Tyr Glu Asn Pro 
                325                 330                 335     


Arg Asp Lys Ile Leu Val Phe Lys Asp Glu Asn Phe Trp Met Ile Arg 
            340                 345                 350         


Gly Tyr Ala Val Leu Pro Asp Tyr Pro Lys Ser Ile His Thr Leu Gly 
        355                 360                 365             


Phe Pro Gly Arg Val Lys Lys Ile Asp Ala Ala Val Cys Asp Lys Thr 
    370                 375                 380                 


Thr Arg Lys Thr Tyr Phe Phe Val Gly Ile Trp Cys Trp Arg Phe Asp 
385                 390                 395                 400 


Glu Met Thr Gln Thr Met Asp Lys Gly Phe Pro Gln Arg Val Val Lys 
                405                 410                 415     


His Phe Pro Gly Ile Ser Ile Arg Val Asp Ala Ala Phe Gln Tyr Lys 
            420                 425                 430         


Gly Phe Phe Phe Phe Ser Arg Gly Ser Lys Gln Phe Glu Tyr Asp Ile 
        435                 440                 445             


Lys Thr Lys Asn Ile Thr Arg Ile Met Arg Thr Asn Thr Trp Phe Gln 
    450                 455                 460                 


Cys Lys Glu Pro Lys Asn Ser Ser Phe Gly Phe Asp Ile Asn Lys Glu 
465                 470                 475                 480 


Lys Ala His Ser Gly Gly Ile Lys Ile Leu Tyr His Lys Ser Leu Ser 
                485                 490                 495     


Leu Phe Ile Phe Gly Ile Val His Leu Leu Lys Asn Thr Ser Ile Tyr 
            500                 505                 510         


Gln 
    


<210>  8804
<211>  89
<212>  PRT
<213>  Homo Sapiens

<400>  8804

Asp Phe Glu Thr Trp Asp Ser Tyr Ser Pro Gln Gly Arg Arg Pro Glu 
1               5                   10                  15      


Thr Gln Gly Pro Lys Tyr Cys His Ser Ser Phe Asp Ala Ile Thr Val 
            20                  25                  30          


Asp Arg Gln Gln Gln Leu Tyr Ile Phe Lys Gly Ser His Phe Trp Glu 
        35                  40                  45              


Val Ala Ala Asp Gly Asn Val Ser Glu Pro Arg Pro Leu Gln Glu Arg 
    50                  55                  60                  


Trp Val Gly Leu Pro Pro Asn Ile Glu Ala Ala Ala Val Ser Leu Asn 
65                  70                  75                  80  


Asp Gly Asp Phe Tyr Phe Phe Lys Ala 
                85                  


<210>  8805
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  8805

Lys Tyr Gly Tyr Leu Asn Glu Gln Val Pro Lys Ala Pro Thr Ser Thr 
1               5                   10                  15      


Arg Phe Ser Asp Ala Ile Arg Ala Phe Gln Trp Val Ser Gln Leu Pro 
            20                  25                  30          


Val Ser Gly Val Leu Asp Arg Ala Thr Leu Arg Gln Met Thr Arg Pro 
        35                  40                  45              


Arg Cys Gly Val Thr Asp Thr Asn Ser Tyr Ala Ala Trp Ala Glu Arg 
    50                  55                  60                  


Ile Ser Asp Leu Phe Ala Arg His Arg Thr Lys Met Arg Arg Lys Lys 
65                  70                  75                  80  


Arg Phe Ala Lys Gln Gly Gly Ala Leu Ala His Ala Phe Leu Pro Arg 
                85                  90                  95      


Arg Gly Glu Ala His Phe Asp Gln Asp Glu Arg Trp Ser Leu Ser Arg 
            100                 105                 110         


Arg Arg Gly Arg Asn Leu Phe Val Val Leu Ala His Glu Ile Gly His 
        115                 120                 125             


Thr Leu Gly Leu Thr His Ser Pro Ala Pro Arg Ala Leu Met Ala Pro 
    130                 135                 140                 


Tyr Tyr Lys Arg Leu Gly Arg Asp Ala Leu Leu Ser Trp Asp Asp Val 
145                 150                 155                 160 


Leu Ala Val Gln Ser Leu Tyr Gly Lys Pro Leu Gly Gly Ser Val Ala 
                165                 170                 175     


Val Gln Leu Pro Gly Lys Leu Phe Thr Asp Phe Glu Thr 
            180                 185                 


<210>  8806
<211>  130
<212>  PRT
<213>  Homo Sapiens

<400>  8806

Met Val Ala Arg Val Gly Leu Leu Leu Arg Ala Leu Gln Leu Leu Leu 
1               5                   10                  15      


Trp Gly His Leu Asp Ala Gln Pro Ala Glu Arg Gly Gly Gln Glu Leu 
            20                  25                  30          


Arg Lys Glu Ala Glu Ala Phe Leu Glu Lys Tyr Gly Tyr Leu Asn Glu 
        35                  40                  45              


Gln Val Pro Lys Ala Pro Thr Ser Thr Arg Phe Ser Asp Ala Ile Arg 
    50                  55                  60                  


Ala Phe Gln Trp Val Ser Gln Leu Pro Val Ser Gly Val Leu Asp Arg 
65                  70                  75                  80  


Ala Thr Leu Arg Gln Met Thr Arg Pro Arg Cys Gly Val Thr Asp Thr 
                85                  90                  95      


Asn Ser Tyr Ala Ala Trp Ala Glu Arg Ile Ser Asp Leu Phe Ala Arg 
            100                 105                 110         


His Arg Thr Lys Met Arg Arg Lys Lys Arg Phe Ala Lys Gln Gly Glu 
        115                 120                 125             


His Cys 
    130 


<210>  8807
<211>  510
<212>  PRT
<213>  Homo Sapiens

<400>  8807

Met Val Ala Arg Val Gly Leu Leu Leu Arg Ala Leu Gln Leu Leu Leu 
1               5                   10                  15      


Trp Gly His Leu Asp Ala Gln Pro Ala Glu Arg Gly Gly Gln Glu Leu 
            20                  25                  30          


Arg Lys Glu Ala Glu Ala Phe Leu Glu Lys Tyr Gly Tyr Leu Asn Glu 
        35                  40                  45              


Gln Val Pro Lys Ala Pro Thr Ser Thr Arg Phe Ser Asp Ala Ile Arg 
    50                  55                  60                  


Ala Phe Gln Trp Val Ser Gln Leu Pro Val Ser Gly Val Leu Asp Arg 
65                  70                  75                  80  


Ala Thr Leu Arg Gln Met Thr Arg Pro Arg Cys Gly Val Thr Asp Thr 
                85                  90                  95      


Asn Ser Tyr Ala Ala Trp Ala Glu Arg Ile Ser Asp Leu Phe Ala Arg 
            100                 105                 110         


His Arg Thr Lys Met Arg Arg Lys Lys Arg Phe Ala Lys Gln Gly Asn 
        115                 120                 125             


Lys Trp Tyr Lys Gln His Leu Ser Tyr Arg Leu Val Asn Trp Pro Glu 
    130                 135                 140                 


His Leu Pro Glu Pro Ala Val Arg Gly Ala Val Arg Ala Ala Phe Gln 
145                 150                 155                 160 


Leu Trp Ser Asn Val Ser Ala Leu Glu Phe Trp Glu Ala Pro Ala Thr 
                165                 170                 175     


Gly Pro Ala Asp Ile Arg Leu Thr Phe Phe Gln Gly Asp His Asn Asp 
            180                 185                 190         


Gly Leu Gly Asn Ala Phe Asp Gly Pro Gly Gly Ala Leu Ala His Ala 
        195                 200                 205             


Phe Leu Pro Arg Arg Gly Glu Ala His Phe Asp Gln Asp Glu Arg Trp 
    210                 215                 220                 


Ser Leu Ser Arg Arg Arg Gly Arg Asn Leu Phe Val Val Leu Ala His 
225                 230                 235                 240 


Glu Ile Gly His Thr Leu Gly Leu Thr His Ser Pro Ala Pro Arg Ala 
                245                 250                 255     


Leu Met Ala Pro Tyr Tyr Lys Arg Leu Gly Arg Asp Ala Leu Leu Ser 
            260                 265                 270         


Trp Asp Asp Val Leu Ala Val Gln Ser Leu Tyr Gly Lys Pro Leu Gly 
        275                 280                 285             


Gly Ser Val Ala Val Gln Leu Pro Gly Lys Leu Phe Thr Asp Phe Glu 
    290                 295                 300                 


Thr Trp Asp Ser Tyr Ser Pro Gln Gly Arg Arg Pro Glu Thr Gln Gly 
305                 310                 315                 320 


Pro Lys Tyr Cys His Ser Ser Phe Asp Ala Ile Thr Val Gly Ser His 
                325                 330                 335     


Phe Trp Glu Val Ala Ala Asp Gly Asn Val Ser Glu Pro Arg Pro Leu 
            340                 345                 350         


Gln Glu Arg Trp Val Gly Leu Pro Pro Asn Ile Glu Ala Ala Ala Val 
        355                 360                 365             


Ser Leu Asn Asp Gly Asp Phe Tyr Phe Phe Lys Gly Gly Arg Cys Trp 
    370                 375                 380                 


Arg Phe Arg Gly Pro Lys Pro Val Trp Gly Leu Pro Gln Leu Cys Arg 
385                 390                 395                 400 


Ala Gly Gly Leu Pro Arg His Pro Asp Ala Ala Leu Phe Phe Pro Pro 
                405                 410                 415     


Leu Arg Arg Leu Ile Leu Phe Lys Gly Ala Arg Tyr Tyr Val Leu Ala 
            420                 425                 430         


Arg Gly Gly Leu Gln Val Glu Pro Tyr Tyr Pro Arg Ser Leu Gln Asp 
        435                 440                 445             


Trp Gly Gly Ile Pro Glu Glu Val Ser Gly Ala Leu Pro Arg Pro Asp 
    450                 455                 460                 


Gly Ser Ile Ile Phe Phe Arg Asp Asp Arg Tyr Trp Arg Leu Asp Gln 
465                 470                 475                 480 


Ala Lys Leu Gln Ala Thr Thr Ser Gly Arg Trp Ala Thr Glu Leu Pro 
                485                 490                 495     


Trp Met Gly Cys Trp His Ala Asn Ser Gly Ser Ala Leu Phe 
            500                 505                 510 


<210>  8808
<211>  393
<212>  PRT
<213>  Homo Sapiens

<400>  8808

Met Val Ala Arg Val Gly Leu Leu Leu Arg Ala Leu Gln Leu Leu Leu 
1               5                   10                  15      


Trp Gly His Leu Asp Ala Gln Pro Ala Glu Arg Gly Gly Gln Glu Leu 
            20                  25                  30          


Arg Lys Glu Ala Glu Ala Phe Leu Glu Lys Tyr Gly Tyr Leu Asn Glu 
        35                  40                  45              


Gln Val Pro Lys Ala Pro Thr Ser Thr Arg Phe Ser Asp Ala Ile Arg 
    50                  55                  60                  


Ala Phe Gln Trp Val Ser Gln Leu Pro Val Ser Gly Val Leu Asp Arg 
65                  70                  75                  80  


Ala Thr Leu Arg Gln Met Thr Arg Pro Arg Cys Gly Val Thr Asp Thr 
                85                  90                  95      


Asn Ser Tyr Ala Ala Trp Ala Glu Arg Ile Ser Asp Leu Phe Ala Arg 
            100                 105                 110         


His Arg Thr Lys Met Arg Arg Lys Lys Arg Phe Ala Lys Gln Gly Asn 
        115                 120                 125             


Lys Trp Tyr Lys Gln His Leu Ser Tyr Arg Leu Val Asn Trp Pro Glu 
    130                 135                 140                 


His Leu Pro Glu Pro Ala Val Arg Gly Ala Val Arg Ala Ala Phe Gln 
145                 150                 155                 160 


Leu Trp Ser Asn Val Ser Ala Leu Glu Phe Trp Glu Ala Pro Ala Thr 
                165                 170                 175     


Gly Pro Ala Asp Ile Arg Leu Thr Phe Phe Gln Gly Asp His Asn Asp 
            180                 185                 190         


Gly Leu Gly Asn Ala Phe Asp Gly Pro Gly Gly Ala Leu Ala His Ala 
        195                 200                 205             


Phe Leu Pro Arg Arg Gly Glu Ala His Phe Asp Gln Asp Glu Arg Trp 
    210                 215                 220                 


Ser Leu Ser Arg Arg Arg Gly Arg Asn Leu Phe Val Val Leu Ala His 
225                 230                 235                 240 


Glu Ile Gly His Thr Leu Gly Leu Thr His Ser Pro Ala Pro Arg Ala 
                245                 250                 255     


Leu Met Ala Pro Tyr Tyr Lys Arg Leu Gly Arg Asp Ala Leu Leu Ser 
            260                 265                 270         


Trp Asp Asp Val Leu Ala Val Gln Ser Leu Tyr Gly Lys Pro Leu Gly 
        275                 280                 285             


Gly Ser Val Ala Val Gln Leu Pro Gly Lys Leu Phe Thr Asp Phe Glu 
    290                 295                 300                 


Thr Trp Asp Ser Tyr Ser Pro Gln Gly Arg Arg Pro Glu Thr Gln Gly 
305                 310                 315                 320 


Pro Lys Tyr Cys His Ser Ser Phe Asp Ala Ile Thr Val Asp Arg Gln 
                325                 330                 335     


Gln Gln Leu Tyr Ile Phe Lys Gly Ser His Phe Trp Glu Val Ala Ala 
            340                 345                 350         


Asp Gly Asn Val Ser Glu Pro Arg Pro Leu Gln Glu Arg Trp Val Gly 
        355                 360                 365             


Leu Pro Pro Asn Ile Glu Ala Ala Ala Val Ser Leu Asn Asp Gly Asp 
    370                 375                 380                 


Phe Tyr Phe Phe Lys Val Gln Ser Val 
385                 390             


<210>  8809
<211>  520
<212>  PRT
<213>  Homo Sapiens

<400>  8809

Met Val Ala Arg Val Gly Leu Leu Leu Arg Ala Leu Gln Leu Leu Leu 
1               5                   10                  15      


Trp Gly His Leu Asp Ala Gln Pro Ala Glu Arg Gly Gly Gln Glu Leu 
            20                  25                  30          


Arg Lys Glu Ala Glu Ala Phe Leu Glu Lys Tyr Gly Tyr Leu Asn Glu 
        35                  40                  45              


Gln Val Pro Lys Ala Pro Thr Ser Thr Arg Phe Ser Asp Ala Ile Arg 
    50                  55                  60                  


Ala Phe Gln Trp Val Ser Gln Leu Pro Val Ser Gly Val Leu Asp Arg 
65                  70                  75                  80  


Ala Thr Leu Arg Gln Met Thr Arg Pro Arg Cys Gly Val Thr Asp Thr 
                85                  90                  95      


Asn Ser Tyr Ala Ala Trp Ala Glu Arg Ile Ser Asp Leu Phe Ala Arg 
            100                 105                 110         


His Arg Thr Lys Met Arg Arg Lys Lys Arg Phe Ala Lys Gln Gly Asn 
        115                 120                 125             


Lys Trp Tyr Lys Gln His Leu Ser Tyr Arg Leu Val Asn Trp Pro Glu 
    130                 135                 140                 


His Leu Pro Glu Pro Ala Val Arg Gly Ala Val Arg Ala Ala Phe Gln 
145                 150                 155                 160 


Leu Trp Ser Asn Val Ser Ala Leu Glu Phe Trp Glu Ala Pro Ala Thr 
                165                 170                 175     


Gly Pro Ala Asp Ile Arg Leu Thr Phe Phe Gln Gly Asp His Asn Asp 
            180                 185                 190         


Gly Leu Gly Asn Ala Phe Asp Gly Pro Gly Gly Ala Leu Ala His Ala 
        195                 200                 205             


Phe Leu Pro Arg Arg Gly Glu Ala His Phe Asp Gln Asp Glu Arg Trp 
    210                 215                 220                 


Ser Leu Ser Arg Arg Arg Gly Arg Asn Leu Phe Val Val Leu Ala His 
225                 230                 235                 240 


Glu Ile Gly His Thr Leu Gly Leu Thr His Ser Pro Ala Pro Arg Ala 
                245                 250                 255     


Leu Met Ala Pro Tyr Tyr Lys Arg Leu Gly Arg Asp Ala Leu Leu Ser 
            260                 265                 270         


Trp Asp Asp Val Leu Ala Val Gln Ser Leu Tyr Gly Lys Pro Leu Gly 
        275                 280                 285             


Gly Ser Val Ala Val Gln Leu Pro Gly Lys Leu Phe Thr Asp Phe Glu 
    290                 295                 300                 


Thr Trp Asp Ser Tyr Ser Pro Gln Gly Arg Arg Pro Glu Thr Gln Gly 
305                 310                 315                 320 


Pro Lys Tyr Cys His Ser Ser Phe Asp Ala Ile Thr Val Asp Arg Gln 
                325                 330                 335     


Gln Gln Leu Tyr Ile Phe Lys Gly Ser His Phe Trp Glu Val Ala Ala 
            340                 345                 350         


Asp Gly Asn Val Ser Glu Pro Arg Pro Leu Gln Glu Arg Trp Val Gly 
        355                 360                 365             


Leu Pro Pro Asn Ile Glu Ala Ala Ala Val Ser Leu Asn Asp Gly Asp 
    370                 375                 380                 


Phe Tyr Phe Phe Lys Gly Gly Arg Cys Trp Arg Phe Arg Gly Pro Lys 
385                 390                 395                 400 


Pro Val Trp Gly Leu Pro Gln Leu Cys Arg Ala Gly Gly Leu Pro Arg 
                405                 410                 415     


His Pro Asp Ala Ala Leu Phe Phe Pro Pro Leu Arg Arg Leu Ile Leu 
            420                 425                 430         


Phe Lys Gly Ala Arg Tyr Tyr Val Leu Ala Arg Gly Gly Leu Gln Val 
        435                 440                 445             


Glu Pro Tyr Tyr Pro Arg Ser Leu Gln Asp Trp Gly Gly Ile Pro Glu 
    450                 455                 460                 


Glu Val Ser Gly Ala Leu Pro Arg Pro Asp Gly Ser Ile Ile Phe Phe 
465                 470                 475                 480 


Arg Asp Asp Arg Tyr Trp Arg Leu Asp Gln Ala Lys Leu Gln Ala Thr 
                485                 490                 495     


Thr Ser Gly Arg Trp Ala Thr Glu Leu Pro Trp Met Gly Cys Trp His 
            500                 505                 510         


Ala Asn Ser Gly Ser Ala Leu Phe 
        515                 520 


<210>  8810
<211>  42
<212>  PRT
<213>  Homo Sapiens

<400>  8810

Met Lys Ser Leu Pro Ile Leu Leu Leu Leu Cys Val Ala Val Cys Ser 
1               5                   10                  15      


Ala Tyr Pro Leu Asp Gly Ala Ala Arg Glu Ile Ser Arg Lys Leu Leu 
            20                  25                  30          


Arg Pro Gln Lys Arg Cys Glu Thr Val Cys 
        35                  40          


<210>  8811
<211>  477
<212>  PRT
<213>  Homo Sapiens

<400>  8811

Met Lys Ser Leu Pro Ile Leu Leu Leu Leu Cys Val Ala Val Cys Ser 
1               5                   10                  15      


Ala Tyr Pro Leu Asp Gly Ala Ala Arg Gly Glu Asp Thr Ser Met Asn 
            20                  25                  30          


Leu Val Gln Lys Tyr Leu Glu Asn Tyr Tyr Asp Leu Lys Lys Asp Val 
        35                  40                  45              


Lys Gln Phe Val Arg Arg Lys Asp Ser Gly Pro Val Val Lys Lys Ile 
    50                  55                  60                  


Arg Glu Met Gln Lys Phe Leu Gly Leu Glu Val Thr Gly Lys Leu Asp 
65                  70                  75                  80  


Ser Asp Thr Leu Glu Val Met Arg Lys Pro Arg Cys Gly Val Pro Asp 
                85                  90                  95      


Val Gly His Phe Arg Thr Phe Pro Gly Ile Pro Lys Trp Arg Lys Thr 
            100                 105                 110         


His Leu Thr Tyr Arg Ile Val Asn Tyr Thr Pro Asp Leu Pro Lys Asp 
        115                 120                 125             


Ala Val Asp Ser Ala Val Glu Lys Ala Leu Lys Val Trp Glu Glu Val 
    130                 135                 140                 


Thr Pro Leu Thr Phe Ser Arg Leu Tyr Glu Gly Glu Ala Asp Ile Met 
145                 150                 155                 160 


Ile Ser Phe Ala Val Arg Glu His Gly Asp Phe Tyr Pro Phe Asp Gly 
                165                 170                 175     


Pro Gly Asn Val Leu Ala His Ala Tyr Ala Pro Gly Pro Gly Ile Asn 
            180                 185                 190         


Gly Asp Ala His Phe Asp Asp Asp Glu Gln Trp Thr Lys Asp Thr Thr 
        195                 200                 205             


Gly Thr Asn Leu Phe Leu Val Ala Ala His Glu Ile Gly His Ser Leu 
    210                 215                 220                 


Gly Leu Phe His Ser Ala Asn Thr Glu Ala Leu Met Tyr Pro Leu Tyr 
225                 230                 235                 240 


His Ser Leu Thr Asp Leu Thr Arg Phe Arg Leu Ser Gln Asp Asp Ile 
                245                 250                 255     


Asn Gly Ile Gln Ser Leu Tyr Gly Pro Pro Pro Asp Ser Pro Glu Thr 
            260                 265                 270         


Pro Leu Val Pro Thr Glu Pro Val Pro Pro Glu Pro Gly Thr Pro Ala 
        275                 280                 285             


Asn Cys Asp Pro Ala Leu Ser Phe Asp Ala Val Ser Thr Leu Arg Gly 
    290                 295                 300                 


Glu Ile Leu Ile Phe Lys Asp Arg His Phe Trp Arg Lys Ser Leu Arg 
305                 310                 315                 320 


Lys Leu Glu Pro Glu Leu His Leu Ile Ser Ser Phe Trp Pro Ser Leu 
                325                 330                 335     


Pro Ser Gly Val Asp Ala Ala Tyr Glu Val Thr Ser Lys Asp Leu Val 
            340                 345                 350         


Phe Ile Phe Lys Gly Asn Gln Phe Trp Ala Ile Arg Gly Asn Glu Val 
        355                 360                 365             


Arg Ala Gly Tyr Pro Arg Gly Ile His Thr Leu Gly Phe Pro Pro Thr 
    370                 375                 380                 


Val Arg Lys Ile Asp Ala Ala Ile Ser Asp Lys Glu Lys Asn Lys Thr 
385                 390                 395                 400 


Tyr Phe Phe Val Glu Asp Lys Tyr Trp Arg Phe Asp Glu Lys Arg Asn 
                405                 410                 415     


Ser Met Glu Pro Gly Phe Pro Lys Gln Ile Ala Glu Asp Phe Pro Gly 
            420                 425                 430         


Ile Asp Ser Lys Ile Asp Ala Val Phe Glu Glu Phe Gly Phe Phe Tyr 
        435                 440                 445             


Phe Phe Thr Gly Ser Ser Gln Leu Glu Phe Asp Pro Asn Ala Lys Lys 
    450                 455                 460                 


Val Thr His Thr Leu Lys Ser Asn Ser Trp Leu Asn Cys 
465                 470                 475         


<210>  8812
<211>  99
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8812

Xaa Asn Gln Phe Trp Ala Ile Arg Gly Asn Glu Val Arg Ala Gly Tyr 
1               5                   10                  15      


Pro Arg Gly Ile His Thr Leu Gly Phe Pro Pro Thr Val Arg Lys Ile 
            20                  25                  30          


Asp Ala Ala Ile Ser Asp Lys Glu Lys Asn Lys Thr Tyr Phe Phe Val 
        35                  40                  45              


Glu Asp Lys Tyr Trp Arg Phe Asp Glu Lys Arg Asn Ser Met Glu Pro 
    50                  55                  60                  


Gly Phe Pro Lys Gln Ile Ala Glu Asp Phe Pro Gly Ile Asp Ser Lys 
65                  70                  75                  80  


Ile Asp Ala Val Phe Glu Glu Phe Asp Arg Ala Gly Thr Glu Cys Cys 
                85                  90                  95      


Leu His Ser 
            


<210>  8813
<211>  267
<212>  PRT
<213>  Homo Sapiens

<400>  8813

Met Arg Leu Thr Val Leu Cys Ala Val Cys Leu Leu Pro Gly Ser Leu 
1               5                   10                  15      


Ala Leu Pro Leu Pro Gln Glu Ala Gly Gly Met Ser Glu Leu Gln Trp 
            20                  25                  30          


Glu Gln Ala Gln Asp Tyr Leu Lys Arg Phe Tyr Leu Tyr Asp Ser Glu 
        35                  40                  45              


Thr Lys Asn Ala Asn Ser Leu Glu Ala Lys Leu Lys Glu Met Gln Lys 
    50                  55                  60                  


Phe Phe Gly Leu Pro Ile Thr Gly Met Leu Asn Ser Arg Val Ile Glu 
65                  70                  75                  80  


Ile Met Gln Lys Pro Arg Cys Gly Val Pro Asp Val Ala Glu Tyr Ser 
                85                  90                  95      


Leu Phe Pro Asn Ser Pro Lys Trp Thr Ser Lys Val Val Thr Tyr Arg 
            100                 105                 110         


Ile Val Ser Tyr Thr Arg Asp Leu Pro His Ile Thr Val Asp Arg Leu 
        115                 120                 125             


Val Ser Lys Ala Leu Asn Met Trp Gly Lys Glu Ile Pro Leu His Phe 
    130                 135                 140                 


Arg Lys Val Val Trp Gly Thr Ala Asp Ile Met Ile Gly Phe Ala Arg 
145                 150                 155                 160 


Gly Ala His Gly Asp Ser Tyr Pro Phe Asp Gly Pro Gly Asn Thr Leu 
                165                 170                 175     


Ala His Ala Phe Ala Pro Gly Thr Gly Leu Gly Gly Asp Ala His Phe 
            180                 185                 190         


Asp Glu Asp Glu Arg Trp Thr Asp Gly Ser Ser Leu Gly Ile Asn Phe 
        195                 200                 205             


Leu Tyr Ala Ala Thr His Glu Leu Gly His Ser Leu Gly Met Gly His 
    210                 215                 220                 


Ser Ser Asp Pro Asn Ala Val Met Tyr Pro Thr Tyr Gly Asn Gly Asp 
225                 230                 235                 240 


Pro Gln Asn Phe Lys Leu Ser Gln Asp Asp Ile Lys Gly Ile Gln Lys 
                245                 250                 255     


Leu Tyr Gly Lys Arg Ser Asn Ser Arg Lys Lys 
            260                 265         


<210>  8814
<211>  467
<212>  PRT
<213>  Homo Sapiens

<400>  8814

Met Phe Ser Leu Lys Thr Leu Pro Phe Leu Leu Leu Leu His Val Gln 
1               5                   10                  15      


Ile Ser Lys Ala Phe Pro Val Ser Ser Lys Glu Lys Asn Thr Lys Thr 
            20                  25                  30          


Val Gln Asp Tyr Leu Glu Lys Phe Tyr Gln Leu Pro Ser Asn Gln Tyr 
        35                  40                  45              


Gln Ser Thr Arg Lys Asn Gly Thr Asn Val Ile Val Glu Lys Leu Lys 
    50                  55                  60                  


Glu Met Gln Arg Phe Phe Gly Leu Asn Val Thr Gly Lys Pro Asn Glu 
65                  70                  75                  80  


Glu Thr Leu Asp Met Met Lys Lys Pro Arg Cys Gly Val Pro Asp Ser 
                85                  90                  95      


Gly Gly Phe Met Leu Thr Pro Gly Asn Pro Lys Trp Glu Arg Thr Asn 
            100                 105                 110         


Leu Thr Tyr Arg Ile Arg Asn Tyr Thr Pro Gln Leu Ser Glu Ala Glu 
        115                 120                 125             


Val Glu Arg Ala Ile Lys Asp Ala Phe Glu Leu Trp Ser Val Ala Ser 
    130                 135                 140                 


Pro Leu Ile Phe Thr Arg Ile Ser Gln Gly Glu Ala Asp Ile Asn Ile 
145                 150                 155                 160 


Ala Phe Tyr Gln Arg Asp His Gly Asp Asn Ser Pro Phe Asp Gly Pro 
                165                 170                 175     


Asn Gly Ile Leu Ala His Ala Phe Gln Pro Gly Gln Gly Ile Gly Gly 
            180                 185                 190         


Asp Ala His Phe Asp Ala Glu Glu Thr Trp Thr Asn Thr Ser Ala Asn 
        195                 200                 205             


Tyr Asn Leu Phe Leu Val Ala Ala His Glu Phe Gly His Ser Leu Gly 
    210                 215                 220                 


Leu Ala His Ser Ser Asp Pro Gly Ala Leu Met Tyr Pro Asn Tyr Ala 
225                 230                 235                 240 


Phe Arg Glu Thr Ser Asn Tyr Ser Leu Pro Gln Asp Asp Ile Asp Gly 
                245                 250                 255     


Ile Gln Ala Ile Tyr Gly Leu Ser Ser Asn Pro Ile Gln Pro Thr Gly 
            260                 265                 270         


Pro Ser Thr Pro Lys Pro Cys Asp Pro Ser Leu Thr Phe Asp Ala Ile 
        275                 280                 285             


Thr Thr Leu Arg Gly Glu Ile Leu Phe Phe Lys Asp Arg Tyr Phe Trp 
    290                 295                 300                 


Arg Arg His Pro Gln Leu Gln Arg Val Glu Met Asn Phe Ile Ser Leu 
305                 310                 315                 320 


Phe Trp Pro Ser Leu Pro Thr Gly Ile Gln Ala Ala Tyr Glu Asp Phe 
                325                 330                 335     


Asp Arg Asp Leu Ile Phe Leu Phe Lys Gly Asn Gln Tyr Trp Ala Leu 
            340                 345                 350         


Ser Gly Tyr Asp Ile Leu Gln Gly Tyr Pro Lys Asp Ile Ser Asn Tyr 
        355                 360                 365             


Gly Phe Pro Ser Ser Val Gln Ala Ile Asp Ala Ala Val Phe Tyr Arg 
    370                 375                 380                 


Ser Lys Thr Tyr Phe Phe Val Asn Asp Gln Phe Trp Arg Tyr Asp Asn 
385                 390                 395                 400 


Gln Arg Gln Phe Met Glu Pro Gly Tyr Pro Lys Ser Ile Ser Gly Ala 
                405                 410                 415     


Phe Pro Gly Ile Glu Ser Lys Val Asp Ala Val Phe Gln Gln Glu His 
            420                 425                 430         


Phe Phe His Val Phe Ser Gly Pro Arg Tyr Tyr Ala Phe Asp Leu Ile 
        435                 440                 445             


Ala Gln Arg Val Thr Arg Val Ala Arg Gly Asn Lys Trp Leu Asn Cys 
    450                 455                 460                 


Arg Tyr Gly 
465         


<210>  8815
<211>  56
<212>  PRT
<213>  Homo Sapiens

<400>  8815

Met Phe Ser Leu Lys Thr Leu Pro Phe Leu Leu Leu Leu His Val Gln 
1               5                   10                  15      


Ile Ser Lys Ala Phe Pro Val Ser Ser Lys Glu Lys Asn Thr Lys Thr 
            20                  25                  30          


Val Gln His Lys Ala Ile Ser Glu Ala Asn Gln Met Gln Pro Pro Asp 
        35                  40                  45              


Leu Gly Leu Pro Ser Leu Gln Asn 
    50                  55      


<210>  8816
<211>  56
<212>  PRT
<213>  Homo Sapiens

<400>  8816

Met Phe Ser Leu Lys Thr Leu Pro Phe Leu Leu Leu Leu His Val Gln 
1               5                   10                  15      


Ile Ser Lys Ala Phe Pro Val Ser Ser Lys Glu Lys Asn Thr Lys Thr 
            20                  25                  30          


Val Gln His Lys Ala Ile Ser Glu Ala Asn Gln Met Gln Pro Pro Asp 
        35                  40                  45              


Leu Gly Leu Pro Ser Leu Gln Asn 
    50                  55      


<210>  8817
<211>  36
<212>  PRT
<213>  Homo Sapiens

<400>  8817

Met Phe Ser Leu Lys Thr Leu Pro Phe Leu Leu Leu Leu His Val Gln 
1               5                   10                  15      


Ile Ser Lys Ala Phe Pro Val Ser Ser Lys Glu Lys Asn Thr Lys Thr 
            20                  25                  30          


Val Gln Asn Lys 
        35      


<210>  8818
<211>  43
<212>  PRT
<213>  Homo Sapiens

<400>  8818

Met Phe Ser Leu Lys Thr Leu Pro Phe Leu Leu Leu Leu His Val Gln 
1               5                   10                  15      


Ile Ser Lys Ala Phe Pro Val Ser Ser Lys Glu Lys Asn Thr Lys Thr 
            20                  25                  30          


Val Gln Arg Gln Lys Tyr Leu Lys Ser Asp Lys 
        35                  40              


<210>  8819
<211>  344
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8819

Xaa Lys Glu Lys Asn Thr Lys Thr Val Gln Asp Tyr Leu Glu Lys Phe 
1               5                   10                  15      


Tyr Gln Leu Pro Ser Asn Gln Tyr Gln Ser Thr Arg Lys Asn Gly Thr 
            20                  25                  30          


Asn Val Ile Val Glu Lys Leu Lys Glu Met Gln Arg Phe Phe Gly Leu 
        35                  40                  45              


Asn Val Thr Gly Lys Pro Asn Glu Glu Thr Leu Asp Met Met Lys Lys 
    50                  55                  60                  


Pro Arg Cys Gly Val Pro Asp Ser Gly Gly Phe Met Leu Thr Pro Gly 
65                  70                  75                  80  


Asn Pro Lys Trp Glu Arg Thr Asn Leu Thr Tyr Arg Ile Arg Asn Tyr 
                85                  90                  95      


Thr Pro Gln Leu Ser Glu Ala Glu Val Glu Arg Ala Ile Lys Asp Ala 
            100                 105                 110         


Phe Glu Leu Trp Ser Val Ala Ser Pro Leu Ile Phe Thr Arg Ile Ser 
        115                 120                 125             


Gln Gly Glu Ala Asp Ile Asn Ile Ala Phe Tyr Gln Arg Asp His Gly 
    130                 135                 140                 


Asp Asn Ser Pro Phe Asp Gly Pro Asn Gly Ile Leu Ala His Ala Phe 
145                 150                 155                 160 


Gln Pro Gly Gln Gly Ile Gly Gly Asp Ala His Phe Asp Ala Glu Glu 
                165                 170                 175     


Thr Trp Thr Asn Thr Ser Ala Asn Tyr Asn Leu Phe Leu Val Ala Ala 
            180                 185                 190         


His Glu Phe Gly His Ser Leu Gly Leu Ala His Ser Ser Asp Pro Gly 
        195                 200                 205             


Ala Leu Met Tyr Pro Asn Tyr Ala Phe Arg Glu Thr Ser Asn Tyr Ser 
    210                 215                 220                 


Leu Pro Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile Tyr Gly Leu Ser 
225                 230                 235                 240 


Ser Asn Pro Ile Gln Pro Thr Gly Pro Ser Thr Pro Lys Pro Cys Asp 
                245                 250                 255     


Pro Ser Leu Thr Phe Asp Ala Ile Thr Thr Leu Arg Gly Glu Ile Leu 
            260                 265                 270         


Phe Phe Lys Asp Arg Tyr Phe Trp Arg Arg His Pro Gln Leu Gln Arg 
        275                 280                 285             


Val Glu Met Asn Phe Ile Ser Leu Phe Trp Pro Ser Leu Pro Thr Gly 
    290                 295                 300                 


Ile Gln Ala Ala Tyr Glu Asp Phe Asp Arg Asp Leu Ile Phe Leu Phe 
305                 310                 315                 320 


Lys Asp Met Ile Thr Lys Asp Asn Ser Trp Ser Gln Val Ile Pro Lys 
                325                 330                 335     


Ala Tyr Gln Val Pro Phe Gln Glu 
            340                 


<210>  8820
<211>  707
<212>  PRT
<213>  Homo Sapiens

<400>  8820

Met Ser Leu Trp Gln Pro Leu Val Leu Val Leu Leu Val Leu Gly Cys 
1               5                   10                  15      


Cys Phe Ala Ala Pro Arg Gln Arg Gln Ser Thr Leu Val Leu Phe Pro 
            20                  25                  30          


Gly Asp Leu Arg Thr Asn Leu Thr Asp Arg Gln Leu Ala Glu Glu Tyr 
        35                  40                  45              


Leu Tyr Arg Tyr Gly Tyr Thr Arg Val Ala Glu Met Arg Gly Glu Ser 
    50                  55                  60                  


Lys Ser Leu Gly Pro Ala Leu Leu Leu Leu Gln Lys Gln Leu Ser Leu 
65                  70                  75                  80  


Pro Glu Thr Gly Glu Leu Asp Ser Ala Thr Leu Lys Ala Met Arg Thr 
                85                  90                  95      


Pro Arg Cys Gly Val Pro Asp Leu Gly Arg Phe Gln Thr Phe Glu Gly 
            100                 105                 110         


Asp Leu Lys Trp His His His Asn Ile Thr Tyr Trp Ile Gln Asn Tyr 
        115                 120                 125             


Ser Glu Asp Leu Pro Arg Ala Val Ile Asp Asp Ala Phe Ala Arg Ala 
    130                 135                 140                 


Phe Ala Leu Trp Ser Ala Val Thr Pro Leu Thr Phe Thr Arg Val Tyr 
145                 150                 155                 160 


Ser Arg Asp Ala Asp Ile Val Ile Gln Phe Gly Val Ala Glu His Gly 
                165                 170                 175     


Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly Leu Leu Ala His Ala Phe 
            180                 185                 190         


Pro Pro Gly Pro Gly Ile Gln Gly Asp Ala His Phe Asp Asp Asp Glu 
        195                 200                 205             


Leu Trp Ser Leu Gly Lys Gly Val Val Val Pro Thr Arg Phe Gly Asn 
    210                 215                 220                 


Ala Asp Gly Ala Ala Cys His Phe Pro Phe Ile Phe Glu Gly Arg Ser 
225                 230                 235                 240 


Tyr Ser Ala Cys Thr Thr Asp Gly Arg Ser Asp Gly Leu Pro Trp Cys 
                245                 250                 255     


Ser Thr Thr Ala Asn Tyr Asp Thr Asp Asp Arg Phe Gly Phe Cys Pro 
            260                 265                 270         


Ser Glu Arg Leu Tyr Thr Gln Asp Gly Asn Ala Asp Gly Lys Pro Cys 
        275                 280                 285             


Gln Phe Pro Phe Ile Phe Gln Gly Gln Ser Tyr Ser Ala Cys Thr Thr 
    290                 295                 300                 


Asp Gly Arg Ser Asp Gly Tyr Arg Trp Cys Ala Thr Thr Ala Asn Tyr 
305                 310                 315                 320 


Asp Arg Asp Lys Leu Phe Gly Phe Cys Pro Thr Arg Ala Asp Ser Thr 
                325                 330                 335     


Val Met Gly Gly Asn Ser Ala Gly Glu Leu Cys Val Phe Pro Phe Thr 
            340                 345                 350         


Phe Leu Gly Lys Glu Tyr Ser Thr Cys Thr Ser Glu Gly Arg Gly Asp 
        355                 360                 365             


Gly Arg Leu Trp Cys Ala Thr Thr Ser Asn Phe Asp Ser Asp Lys Lys 
    370                 375                 380                 


Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser Leu Phe Leu Val Ala Ala 
385                 390                 395                 400 


His Glu Phe Gly His Ala Leu Gly Leu Asp His Ser Ser Val Pro Glu 
                405                 410                 415     


Ala Leu Met Tyr Pro Met Tyr Arg Phe Thr Glu Gly Pro Pro Leu His 
            420                 425                 430         


Lys Asp Asp Val Asn Gly Ile Arg His Leu Tyr Gly Pro Arg Pro Glu 
        435                 440                 445             


Pro Glu Pro Arg Pro Pro Thr Thr Thr Thr Pro Gln Pro Thr Ala Pro 
    450                 455                 460                 


Pro Thr Val Cys Pro Thr Gly Pro Pro Thr Val His Pro Ser Glu Arg 
465                 470                 475                 480 


Pro Thr Ala Gly Pro Thr Gly Pro Pro Ser Ala Gly Pro Thr Gly Pro 
                485                 490                 495     


Pro Thr Ala Gly Pro Ser Thr Ala Thr Thr Val Pro Leu Ser Pro Val 
            500                 505                 510         


Asp Asp Ala Cys Asn Val Asn Ile Phe Asp Ala Ile Ala Glu Ile Gly 
        515                 520                 525             


Asn Gln Leu Tyr Leu Phe Lys Asp Gly Lys Tyr Trp Arg Phe Ser Glu 
    530                 535                 540                 


Gly Arg Gly Ser Arg Pro Gln Gly Pro Phe Leu Ile Ala Asp Lys Trp 
545                 550                 555                 560 


Pro Ala Leu Pro Arg Lys Leu Asp Ser Val Phe Glu Glu Arg Leu Ser 
                565                 570                 575     


Lys Lys Leu Phe Phe Phe Ser Gly Arg Gln Val Trp Val Tyr Thr Gly 
            580                 585                 590         


Ala Ser Val Leu Gly Pro Arg Arg Leu Asp Lys Leu Gly Leu Gly Ala 
        595                 600                 605             


Asp Val Ala Gln Val Thr Gly Ala Leu Arg Ser Gly Arg Gly Lys Met 
    610                 615                 620                 


Leu Leu Phe Ser Gly Arg Arg Leu Trp Arg Phe Asp Val Lys Ala Gln 
625                 630                 635                 640 


Met Val Asp Pro Arg Ser Ala Ser Glu Val Asp Arg Met Phe Pro Gly 
                645                 650                 655     


Val Pro Leu Asp Thr His Asp Val Phe Gln Tyr Arg Glu Lys Ala Tyr 
            660                 665                 670         


Phe Cys Gln Asp Arg Phe Tyr Trp Arg Val Ser Ser Arg Ser Glu Leu 
        675                 680                 685             


Asn Gln Val Asp Gln Val Gly Tyr Val Thr Tyr Asp Ile Leu Gln Cys 
    690                 695                 700                 


Pro Glu Asp 
705         


<210>  8821
<211>  1228
<212>  PRT
<213>  Homo Sapiens

<400>  8821

Met Lys Gly Ala Arg Leu Phe Val Leu Leu Ser Ser Leu Trp Ser Gly 
1               5                   10                  15      


Gly Ile Gly Leu Asn Asn Ser Lys His Ser Trp Thr Ile Pro Glu Asp 
            20                  25                  30          


Gly Asn Ser Gln Lys Thr Met Pro Ser Ala Ser Val Pro Pro Asn Lys 
        35                  40                  45              


Ile Gln Ser Leu Gln Ile Leu Pro Thr Thr Arg Val Met Ser Ala Glu 
    50                  55                  60                  


Ile Ala Thr Thr Pro Glu Ala Arg Thr Ser Glu Asp Ser Leu Leu Lys 
65                  70                  75                  80  


Ser Thr Leu Pro Pro Ser Glu Thr Ser Ala Pro Ala Glu Gly Val Arg 
                85                  90                  95      


Asn Gln Thr Leu Thr Ser Thr Glu Lys Ala Glu Gly Val Val Lys Leu 
            100                 105                 110         


Gln Asn Leu Thr Leu Pro Thr Asn Ala Ser Ile Lys Phe Asn Pro Gly 
        115                 120                 125             


Ala Glu Ser Val Val Leu Ser Asn Ser Thr Leu Lys Phe Leu Gln Ser 
    130                 135                 140                 


Phe Ala Arg Lys Ser Asn Glu Gln Ala Thr Ser Leu Asn Thr Val Gly 
145                 150                 155                 160 


Gly Thr Gly Gly Ile Gly Gly Val Gly Gly Thr Gly Gly Val Gly Asn 
                165                 170                 175     


Arg Ala Pro Arg Glu Thr Tyr Leu Ser Arg Gly Asp Ser Ser Ser Ser 
            180                 185                 190         


Gln Arg Thr Asp Tyr Gln Lys Ser Asn Phe Glu Thr Thr Arg Gly Lys 
        195                 200                 205             


Asn Trp Cys Ala Tyr Val His Thr Arg Leu Ser Pro Thr Val Ile Leu 
    210                 215                 220                 


Asp Asn Gln Val Thr Tyr Val Pro Gly Gly Lys Gly Pro Cys Gly Trp 
225                 230                 235                 240 


Thr Gly Gly Ser Cys Pro Gln Arg Ser Gln Lys Ile Ser Asn Pro Val 
                245                 250                 255     


Tyr Arg Met Gln His Lys Ile Val Thr Ser Leu Asp Trp Arg Cys Cys 
            260                 265                 270         


Pro Gly Tyr Ser Gly Pro Lys Cys Gln Leu Arg Ala Gln Glu Gln Gln 
        275                 280                 285             


Ser Leu Ile His Thr Asn Gln Ala Glu Ser His Thr Ala Val Gly Arg 
    290                 295                 300                 


Gly Val Ala Glu Gln Gln Gln Gln Gln Gly Cys Gly Asp Pro Glu Val 
305                 310                 315                 320 


Met Gln Lys Met Thr Asp Gln Val Asn Tyr Gln Ala Met Lys Leu Thr 
                325                 330                 335     


Leu Leu Gln Lys Lys Ile Asp Asn Ile Ser Leu Thr Val Asn Asp Val 
            340                 345                 350         


Arg Asn Thr Tyr Ser Ser Leu Glu Gly Lys Val Ser Glu Asp Lys Ser 
        355                 360                 365             


Arg Glu Phe Gln Ser Leu Leu Lys Gly Leu Lys Ser Lys Ser Ile Asn 
    370                 375                 380                 


Val Leu Ile Arg Asp Ile Val Arg Glu Gln Phe Lys Ile Phe Gln Asn 
385                 390                 395                 400 


Asp Met Gln Glu Thr Val Ala Gln Leu Phe Lys Thr Val Ser Ser Leu 
                405                 410                 415     


Ser Glu Asp Leu Glu Ser Thr Arg Gln Ile Ile Gln Lys Val Asn Glu 
            420                 425                 430         


Ser Val Val Ser Ile Ala Ala Gln Gln Lys Phe Val Leu Val Gln Glu 
        435                 440                 445             


Asn Arg Pro Thr Leu Thr Asp Ile Val Glu Leu Arg Asn His Ile Val 
    450                 455                 460                 


Asn Val Arg Gln Glu Met Thr Leu Thr Cys Glu Lys Pro Ile Lys Glu 
465                 470                 475                 480 


Leu Glu Val Lys Gln Thr His Leu Glu Gly Ala Leu Glu Gln Glu His 
                485                 490                 495     


Ser Arg Ser Ile Leu Tyr Tyr Glu Ser Leu Asn Lys Thr Leu Ser Lys 
            500                 505                 510         


Leu Lys Glu Val His Glu Gln Leu Leu Ser Thr Glu Gln Val Ser Asp 
        515                 520                 525             


Gln Lys Asn Ala Pro Ala Ala Glu Ser Val Ser Asn Asn Val Thr Glu 
    530                 535                 540                 


Tyr Met Ser Thr Leu His Glu Asn Ile Lys Lys Gln Ser Leu Met Met 
545                 550                 555                 560 


Leu Gln Met Phe Glu Asp Leu His Ile Gln Glu Ser Lys Ile Asn Asn 
                565                 570                 575     


Leu Thr Val Ser Leu Glu Met Glu Lys Glu Ser Leu Arg Gly Glu Cys 
            580                 585                 590         


Glu Asp Met Leu Ser Lys Cys Arg Asn Asp Phe Lys Phe Gln Leu Lys 
        595                 600                 605             


Asp Thr Glu Glu Asn Leu His Val Leu Asn Gln Thr Leu Ala Glu Val 
    610                 615                 620                 


Leu Phe Pro Met Asp Asn Lys Met Asp Lys Met Ser Glu Gln Leu Asn 
625                 630                 635                 640 


Asp Leu Thr Tyr Asp Met Glu Ile Leu Gln Pro Leu Leu Glu Gln Gly 
                645                 650                 655     


Ala Ser Leu Arg Gln Thr Met Thr Tyr Glu Gln Pro Lys Glu Ala Ile 
            660                 665                 670         


Val Ile Arg Lys Lys Ile Glu Asn Leu Thr Ser Ala Val Asn Ser Leu 
        675                 680                 685             


Asn Phe Ile Ile Lys Glu Leu Thr Lys Arg His Asn Leu Leu Arg Asn 
    690                 695                 700                 


Glu Val Gln Gly Arg Asp Asp Ala Leu Glu Arg Arg Ile Asn Glu Tyr 
705                 710                 715                 720 


Ala Leu Glu Met Glu Asp Gly Leu Asn Lys Thr Met Thr Ile Ile Asn 
                725                 730                 735     


Asn Ala Ile Asp Phe Ile Gln Asp Asn Tyr Ala Leu Lys Glu Thr Leu 
            740                 745                 750         


Ser Thr Ile Lys Asp Asn Ser Glu Ile His His Lys Cys Thr Ser Asp 
        755                 760                 765             


Met Glu Thr Ile Leu Thr Phe Ile Pro Gln Phe His Arg Leu Asn Asp 
    770                 775                 780                 


Ser Ile Gln Thr Leu Val Asn Asp Asn Gln Arg Tyr Asn Phe Val Leu 
785                 790                 795                 800 


Gln Val Ala Lys Thr Leu Ala Gly Ile Pro Arg Asp Glu Lys Leu Asn 
                805                 810                 815     


Gln Ser Asn Phe Gln Lys Met Tyr Gln Met Phe Asn Glu Thr Thr Ser 
            820                 825                 830         


Gln Val Arg Lys Tyr Gln Gln Asn Met Ser His Leu Glu Glu Lys Leu 
        835                 840                 845             


Leu Leu Thr Thr Lys Ile Ser Lys Asn Phe Glu Thr Arg Leu Gln Asp 
    850                 855                 860                 


Ile Glu Ser Lys Val Thr Gln Thr Leu Ile Pro Tyr Tyr Ile Ser Val 
865                 870                 875                 880 


Lys Lys Gly Ser Val Val Thr Asn Glu Arg Asp Gln Ala Leu Gln Leu 
                885                 890                 895     


Gln Val Leu Asn Ser Arg Phe Lys Ala Leu Glu Ala Lys Ser Ile His 
            900                 905                 910         


Leu Ser Ile Asn Phe Phe Ser Leu Asn Lys Thr Leu His Glu Val Leu 
        915                 920                 925             


Thr Met Cys His Asn Ala Ser Thr Ser Val Ser Glu Leu Asn Ala Thr 
    930                 935                 940                 


Ile Pro Lys Trp Ile Lys His Ser Leu Pro Asp Ile Gln Leu Leu Gln 
945                 950                 955                 960 


Lys Gly Leu Thr Glu Phe Val Glu Pro Ile Ile Gln Ile Lys Thr Gln 
                965                 970                 975     


Ala Ala Leu Ser Asn Leu Thr Cys Cys Ile Asp Arg Ser Leu Pro Gly 
            980                 985                 990         


Ser Leu Ala Asn Val Val Lys Ser  Gln Lys Gln Val Lys  Ser Leu Pro 
        995                 1000                 1005             


Lys Lys  Ile Asn Ala Leu Lys  Lys Pro Thr Val Asn  Leu Thr Thr 
    1010                 1015                 1020             


Val Leu  Ile Gly Arg Thr Gln  Arg Asn Thr Asp Asn  Ile Ile Tyr 
    1025                 1030                 1035             


Pro Glu  Glu Tyr Ser Ser Cys  Ser Arg His Pro Cys  Gln Asn Gly 
    1040                 1045                 1050             


Gly Thr  Cys Ile Asn Gly Arg  Thr Ser Phe Thr Cys  Ala Cys Arg 
    1055                 1060                 1065             


His Pro  Phe Thr Gly Asp Asn  Cys Thr Ile Lys Leu  Val Glu Glu 
    1070                 1075                 1080             


Asn Ala  Leu Ala Pro Asp Phe  Ser Lys Gly Ser Tyr  Arg Tyr Ala 
    1085                 1090                 1095             


Pro Met  Val Ala Phe Phe Ala  Ser His Thr Tyr Gly  Met Thr Ile 
    1100                 1105                 1110             


Pro Gly  Pro Ile Leu Phe Asn  Asn Leu Asp Val Asn  Tyr Gly Ala 
    1115                 1120                 1125             


Ser Tyr  Thr Pro Arg Thr Gly  Lys Phe Arg Ile Pro  Tyr Leu Gly 
    1130                 1135                 1140             


Val Tyr  Val Phe Lys Tyr Thr  Ile Glu Ser Phe Ser  Ala His Ile 
    1145                 1150                 1155             


Ser Gly  Phe Leu Val Val Asp  Gly Ile Asp Lys Leu  Ala Phe Glu 
    1160                 1165                 1170             


Ser Glu  Asn Ile Asn Ser Glu  Ile His Cys Asp Arg  Val Leu Thr 
    1175                 1180                 1185             


Gly Asp  Ala Leu Leu Glu Leu  Asn Tyr Gly Gln Glu  Val Trp Leu 
    1190                 1195                 1200             


Arg Leu  Ala Lys Gly Thr Ile  Pro Ala Lys Phe Pro  Pro Val Thr 
    1205                 1210                 1215             


Thr Phe  Ser Gly Tyr Leu Leu  Tyr Arg Thr 
    1220                 1225             


<210>  8822
<211>  1228
<212>  PRT
<213>  Homo Sapiens

<400>  8822

Met Lys Gly Ala Arg Leu Phe Val Leu Leu Ser Ser Leu Trp Ser Gly 
1               5                   10                  15      


Gly Ile Gly Leu Asn Asn Ser Lys His Ser Trp Thr Ile Pro Glu Asp 
            20                  25                  30          


Gly Asn Ser Gln Lys Thr Met Pro Ser Ala Ser Val Pro Pro Asn Lys 
        35                  40                  45              


Ile Gln Ser Leu Gln Ile Leu Pro Thr Thr Arg Val Met Ser Ala Glu 
    50                  55                  60                  


Ile Ala Thr Thr Pro Glu Ala Arg Thr Ser Glu Asp Ser Leu Leu Lys 
65                  70                  75                  80  


Ser Thr Leu Pro Pro Ser Glu Thr Ser Ala Pro Ala Glu Gly Val Arg 
                85                  90                  95      


Asn Gln Thr Leu Thr Ser Thr Glu Lys Ala Glu Gly Val Val Lys Leu 
            100                 105                 110         


Gln Asn Leu Thr Leu Pro Thr Asn Ala Ser Ile Lys Phe Asn Pro Gly 
        115                 120                 125             


Ala Glu Ser Val Val Leu Ser Asn Ser Thr Leu Lys Phe Leu Gln Ser 
    130                 135                 140                 


Phe Ala Arg Lys Ser Asn Glu Gln Ala Thr Ser Leu Asn Thr Val Gly 
145                 150                 155                 160 


Gly Thr Gly Gly Ile Gly Gly Val Gly Gly Thr Gly Gly Val Gly Asn 
                165                 170                 175     


Arg Ala Pro Arg Glu Thr Tyr Leu Ser Arg Gly Asp Ser Ser Ser Ser 
            180                 185                 190         


Gln Arg Thr Asp Tyr Gln Lys Ser Asn Phe Glu Thr Thr Arg Gly Lys 
        195                 200                 205             


Asn Trp Cys Ala Tyr Val His Thr Arg Leu Ser Pro Thr Val Ile Leu 
    210                 215                 220                 


Asp Asn Gln Val Thr Tyr Val Pro Gly Gly Lys Gly Pro Cys Gly Trp 
225                 230                 235                 240 


Thr Gly Gly Ser Cys Pro Gln Arg Ser Gln Lys Ile Ser Asn Pro Val 
                245                 250                 255     


Tyr Arg Met Gln His Lys Ile Val Thr Ser Leu Asp Trp Arg Cys Cys 
            260                 265                 270         


Pro Gly Tyr Ser Gly Pro Lys Cys Gln Leu Arg Ala Gln Glu Gln Gln 
        275                 280                 285             


Ser Leu Ile His Thr Asn Gln Ala Glu Ser His Thr Ala Val Gly Arg 
    290                 295                 300                 


Gly Val Ala Glu Gln Gln Gln Gln Gln Gly Cys Gly Asp Pro Glu Val 
305                 310                 315                 320 


Met Gln Lys Met Thr Asp Gln Val Asn Tyr Gln Ala Met Lys Leu Thr 
                325                 330                 335     


Leu Leu Gln Lys Lys Ile Asp Asn Ile Ser Leu Thr Val Asn Asp Val 
            340                 345                 350         


Arg Asn Thr Tyr Ser Ser Leu Glu Gly Lys Val Ser Glu Asp Lys Ser 
        355                 360                 365             


Arg Glu Phe Gln Ser Leu Leu Lys Gly Leu Lys Ser Lys Ser Ile Asn 
    370                 375                 380                 


Val Leu Ile Arg Asp Ile Val Arg Glu Gln Phe Lys Ile Phe Gln Asn 
385                 390                 395                 400 


Asp Met Gln Glu Thr Val Ala Gln Leu Phe Lys Thr Val Ser Ser Leu 
                405                 410                 415     


Ser Glu Asp Leu Glu Ser Thr Arg Gln Ile Ile Gln Lys Val Asn Glu 
            420                 425                 430         


Ser Val Val Ser Ile Ala Ala Gln Gln Lys Phe Val Leu Val Gln Glu 
        435                 440                 445             


Asn Arg Pro Thr Leu Thr Asp Ile Val Glu Leu Arg Asn His Ile Val 
    450                 455                 460                 


Asn Val Arg Gln Glu Met Thr Leu Thr Cys Glu Lys Pro Ile Lys Glu 
465                 470                 475                 480 


Leu Glu Val Lys Gln Thr His Leu Glu Gly Ala Leu Glu Gln Glu His 
                485                 490                 495     


Ser Arg Ser Ile Leu Tyr Tyr Glu Ser Leu Asn Lys Thr Leu Ser Lys 
            500                 505                 510         


Leu Lys Glu Val His Glu Gln Leu Leu Ser Thr Glu Gln Val Ser Asp 
        515                 520                 525             


Gln Lys Asn Ala Pro Ala Ala Glu Ser Val Ser Asn Asn Val Thr Glu 
    530                 535                 540                 


Tyr Met Ser Thr Leu His Glu Asn Ile Lys Lys Gln Ser Leu Met Met 
545                 550                 555                 560 


Leu Gln Met Phe Glu Asp Leu His Ile Gln Glu Ser Lys Ile Asn Asn 
                565                 570                 575     


Leu Thr Val Ser Leu Glu Met Glu Lys Glu Ser Leu Arg Gly Glu Cys 
            580                 585                 590         


Glu Asp Met Leu Ser Lys Cys Arg Asn Asp Phe Lys Phe Gln Leu Lys 
        595                 600                 605             


Asp Thr Glu Glu Asn Leu His Val Leu Asn Gln Thr Leu Ala Glu Val 
    610                 615                 620                 


Leu Phe Pro Met Asp Asn Lys Met Asp Lys Met Ser Glu Gln Leu Asn 
625                 630                 635                 640 


Asp Leu Thr Tyr Asp Met Glu Ile Leu Gln Pro Leu Leu Glu Gln Gly 
                645                 650                 655     


Ala Ser Leu Arg Gln Thr Met Thr Tyr Glu Gln Pro Lys Glu Ala Ile 
            660                 665                 670         


Val Ile Arg Lys Lys Ile Glu Asn Leu Thr Ser Ala Val Asn Ser Leu 
        675                 680                 685             


Asn Phe Ile Ile Lys Glu Leu Thr Lys Arg His Asn Leu Leu Arg Asn 
    690                 695                 700                 


Glu Val Gln Gly Arg Asp Asp Ala Leu Glu Arg Arg Ile Asn Glu Tyr 
705                 710                 715                 720 


Ala Leu Glu Met Glu Asp Gly Leu Asn Lys Thr Met Thr Ile Ile Asn 
                725                 730                 735     


Asn Ala Ile Asp Phe Ile Gln Asp Asn Tyr Ala Leu Lys Glu Thr Leu 
            740                 745                 750         


Ser Thr Ile Lys Asp Asn Ser Glu Ile His His Lys Cys Thr Ser Asp 
        755                 760                 765             


Met Glu Thr Ile Leu Thr Phe Ile Pro Gln Phe His Arg Leu Asn Asp 
    770                 775                 780                 


Ser Ile Gln Thr Leu Val Asn Asp Asn Gln Arg Tyr Asn Phe Val Leu 
785                 790                 795                 800 


Gln Val Ala Lys Thr Leu Ala Gly Ile Pro Arg Asp Glu Lys Leu Asn 
                805                 810                 815     


Gln Ser Asn Phe Gln Lys Met Tyr Gln Met Phe Asn Glu Thr Thr Ser 
            820                 825                 830         


Gln Val Arg Lys Tyr Gln Gln Asn Met Ser His Leu Glu Glu Lys Leu 
        835                 840                 845             


Leu Leu Thr Thr Lys Ile Ser Lys Asn Phe Glu Thr Arg Leu Gln Asp 
    850                 855                 860                 


Ile Glu Ser Lys Val Thr Gln Thr Leu Ile Pro Tyr Tyr Ile Ser Val 
865                 870                 875                 880 


Lys Lys Gly Ser Val Val Thr Asn Glu Arg Asp Gln Ala Leu Gln Leu 
                885                 890                 895     


Gln Val Leu Asn Ser Arg Phe Lys Ala Leu Glu Ala Lys Ser Ile His 
            900                 905                 910         


Leu Ser Ile Asn Phe Phe Ser Leu Asn Lys Thr Leu His Glu Val Leu 
        915                 920                 925             


Thr Met Cys His Asn Ala Ser Thr Ser Val Ser Glu Leu Asn Ala Thr 
    930                 935                 940                 


Ile Pro Lys Trp Ile Lys His Ser Leu Pro Asp Ile Gln Leu Leu Gln 
945                 950                 955                 960 


Lys Gly Leu Thr Glu Phe Val Glu Pro Ile Ile Gln Ile Lys Thr Gln 
                965                 970                 975     


Ala Ala Leu Ser Asn Leu Thr Cys Cys Ile Asp Arg Ser Leu Pro Gly 
            980                 985                 990         


Ser Leu Ala Asn Val Val Lys Ser  Gln Lys Gln Val Lys  Ser Leu Pro 
        995                 1000                 1005             


Lys Lys  Ile Asn Ala Leu Lys  Lys Pro Thr Val Asn  Leu Thr Thr 
    1010                 1015                 1020             


Val Leu  Ile Gly Arg Thr Gln  Arg Asn Thr Asp Asn  Ile Ile Tyr 
    1025                 1030                 1035             


Pro Glu  Glu Tyr Ser Ser Cys  Ser Arg His Pro Cys  Gln Asn Gly 
    1040                 1045                 1050             


Gly Thr  Cys Ile Asn Gly Arg  Thr Ser Phe Thr Cys  Ala Cys Arg 
    1055                 1060                 1065             


His Pro  Phe Thr Gly Asp Asn  Cys Thr Ile Lys Leu  Val Glu Glu 
    1070                 1075                 1080             


Asn Ala  Leu Ala Pro Asp Phe  Ser Lys Gly Ser Tyr  Arg Tyr Ala 
    1085                 1090                 1095             


Pro Met  Val Ala Phe Phe Ala  Ser His Thr Tyr Gly  Met Thr Ile 
    1100                 1105                 1110             


Pro Gly  Pro Ile Leu Phe Asn  Asn Leu Asp Val Asn  Tyr Gly Ala 
    1115                 1120                 1125             


Ser Tyr  Thr Pro Arg Thr Gly  Lys Phe Arg Ile Pro  Tyr Leu Gly 
    1130                 1135                 1140             


Val Tyr  Val Phe Lys Tyr Thr  Ile Glu Ser Phe Ser  Ala His Ile 
    1145                 1150                 1155             


Ser Gly  Phe Leu Val Val Asp  Gly Ile Asp Lys Leu  Ala Phe Glu 
    1160                 1165                 1170             


Ser Glu  Asn Ile Asn Ser Glu  Ile His Cys Asp Arg  Val Leu Thr 
    1175                 1180                 1185             


Gly Asp  Ala Leu Leu Glu Leu  Asn Tyr Gly Gln Glu  Val Trp Leu 
    1190                 1195                 1200             


Arg Leu  Ala Lys Gly Thr Ile  Pro Ala Lys Phe Pro  Pro Val Thr 
    1205                 1210                 1215             


Thr Phe  Ser Gly Tyr Leu Leu  Tyr Arg Thr 
    1220                 1225             


<210>  8823
<211>  970
<212>  PRT
<213>  Homo Sapiens

<400>  8823

Met Gln His Lys Ile Val Thr Ser Leu Asp Trp Arg Cys Cys Pro Gly 
1               5                   10                  15      


Tyr Ser Gly Pro Lys Cys Gln Leu Arg Ala Gln Glu Gln Gln Ser Leu 
            20                  25                  30          


Ile His Thr Asn Gln Ala Glu Ser His Thr Ala Val Gly Arg Gly Val 
        35                  40                  45              


Ala Glu Gln Gln Gln Gln Gln Gly Cys Gly Asp Pro Glu Val Met Gln 
    50                  55                  60                  


Lys Met Thr Asp Gln Val Asn Tyr Gln Ala Met Lys Leu Thr Leu Leu 
65                  70                  75                  80  


Gln Lys Lys Ile Asp Asn Ile Ser Leu Thr Val Asn Asp Val Arg Asn 
                85                  90                  95      


Thr Tyr Ser Ser Leu Glu Gly Lys Val Ser Glu Asp Lys Ser Arg Glu 
            100                 105                 110         


Phe Gln Ser Leu Leu Lys Gly Leu Lys Ser Lys Ser Ile Asn Val Leu 
        115                 120                 125             


Ile Arg Asp Ile Val Arg Glu Gln Phe Lys Ile Phe Gln Asn Asp Met 
    130                 135                 140                 


Gln Glu Thr Val Ala Gln Leu Phe Lys Thr Val Ser Ser Leu Ser Glu 
145                 150                 155                 160 


Asp Leu Glu Ser Thr Arg Gln Ile Ile Gln Lys Val Asn Glu Ser Val 
                165                 170                 175     


Val Ser Ile Ala Ala Gln Gln Lys Phe Val Leu Val Gln Glu Asn Arg 
            180                 185                 190         


Pro Thr Leu Thr Asp Ile Val Glu Leu Arg Asn His Ile Val Asn Val 
        195                 200                 205             


Arg Gln Glu Met Thr Leu Thr Cys Glu Lys Pro Ile Lys Glu Leu Glu 
    210                 215                 220                 


Val Lys Gln Thr His Leu Glu Gly Ala Leu Glu Gln Glu His Ser Arg 
225                 230                 235                 240 


Ser Ile Leu Tyr Tyr Glu Ser Leu Asn Lys Thr Leu Ser Lys Leu Lys 
                245                 250                 255     


Glu Val His Glu Gln Leu Leu Ser Thr Glu Gln Val Ser Asp Gln Lys 
            260                 265                 270         


Asn Ala Pro Ala Ala Glu Ser Val Ser Asn Asn Val Thr Glu Tyr Met 
        275                 280                 285             


Ser Thr Leu His Glu Asn Ile Lys Lys Gln Ser Leu Met Met Leu Gln 
    290                 295                 300                 


Met Phe Glu Asp Leu His Ile Gln Glu Ser Lys Ile Asn Asn Leu Thr 
305                 310                 315                 320 


Val Ser Leu Glu Met Glu Lys Glu Ser Leu Arg Gly Glu Cys Glu Asp 
                325                 330                 335     


Met Leu Ser Lys Cys Arg Asn Asp Phe Lys Phe Gln Leu Lys Asp Thr 
            340                 345                 350         


Glu Glu Asn Leu His Val Leu Asn Gln Thr Leu Ala Glu Val Leu Phe 
        355                 360                 365             


Pro Met Asp Asn Lys Met Asp Lys Met Ser Glu Gln Leu Asn Asp Leu 
    370                 375                 380                 


Thr Tyr Asp Met Glu Ile Leu Gln Pro Leu Leu Glu Gln Gly Ala Ser 
385                 390                 395                 400 


Leu Arg Gln Thr Met Thr Tyr Glu Gln Pro Lys Glu Ala Ile Val Ile 
                405                 410                 415     


Arg Lys Lys Ile Glu Asn Leu Thr Ser Ala Val Asn Ser Leu Asn Phe 
            420                 425                 430         


Ile Ile Lys Glu Leu Thr Lys Arg His Asn Leu Leu Arg Asn Glu Val 
        435                 440                 445             


Gln Gly Arg Asp Asp Ala Leu Glu Arg Arg Ile Asn Glu Tyr Ala Leu 
    450                 455                 460                 


Glu Met Glu Asp Gly Leu Asn Lys Thr Met Thr Ile Ile Asn Asn Ala 
465                 470                 475                 480 


Ile Asp Phe Ile Gln Asp Asn Tyr Ala Leu Lys Glu Thr Leu Ser Thr 
                485                 490                 495     


Ile Lys Asp Asn Ser Glu Ile His His Lys Cys Thr Ser Asp Met Glu 
            500                 505                 510         


Thr Ile Leu Thr Phe Ile Pro Gln Phe His Arg Leu Asn Asp Ser Ile 
        515                 520                 525             


Gln Thr Leu Val Asn Asp Asn Gln Arg Tyr Asn Phe Val Leu Gln Val 
    530                 535                 540                 


Ala Lys Thr Leu Ala Gly Ile Pro Arg Asp Glu Lys Leu Asn Gln Ser 
545                 550                 555                 560 


Asn Phe Gln Lys Met Tyr Gln Met Phe Asn Glu Thr Thr Ser Gln Val 
                565                 570                 575     


Arg Lys Tyr Gln Gln Asn Met Ser His Leu Glu Glu Lys Leu Leu Leu 
            580                 585                 590         


Thr Thr Lys Ile Ser Lys Asn Phe Glu Thr Arg Leu Gln Asp Ile Glu 
        595                 600                 605             


Ser Lys Val Thr Gln Thr Leu Ile Pro Tyr Tyr Ile Ser Val Lys Lys 
    610                 615                 620                 


Gly Ser Val Val Thr Asn Glu Arg Asp Gln Ala Leu Gln Leu Gln Val 
625                 630                 635                 640 


Leu Asn Ser Arg Phe Lys Ala Leu Glu Ala Lys Ser Ile His Leu Ser 
                645                 650                 655     


Ile Asn Phe Phe Ser Leu Asn Lys Thr Leu His Glu Val Leu Thr Met 
            660                 665                 670         


Cys His Asn Ala Ser Thr Ser Val Ser Glu Leu Asn Ala Thr Ile Pro 
        675                 680                 685             


Lys Trp Ile Lys His Ser Leu Pro Asp Ile Gln Leu Leu Gln Lys Gly 
    690                 695                 700                 


Leu Thr Glu Phe Val Glu Pro Ile Ile Gln Ile Lys Thr Gln Ala Ala 
705                 710                 715                 720 


Leu Ser Asn Leu Thr Cys Cys Ile Asp Arg Ser Leu Pro Gly Ser Leu 
                725                 730                 735     


Ala Asn Val Val Lys Ser Gln Lys Gln Val Lys Ser Leu Pro Lys Lys 
            740                 745                 750         


Ile Asn Ala Leu Lys Lys Pro Thr Val Asn Leu Thr Thr Val Leu Ile 
        755                 760                 765             


Gly Arg Thr Gln Arg Asn Thr Asp Asn Ile Ile Tyr Pro Glu Glu Tyr 
    770                 775                 780                 


Ser Ser Cys Ser Arg His Pro Cys Gln Asn Gly Gly Thr Cys Ile Asn 
785                 790                 795                 800 


Gly Arg Thr Ser Phe Thr Cys Ala Cys Arg His Pro Phe Thr Gly Asp 
                805                 810                 815     


Asn Cys Thr Ile Lys Leu Val Glu Glu Asn Ala Leu Ala Pro Asp Phe 
            820                 825                 830         


Ser Lys Gly Ser Tyr Arg Tyr Ala Pro Met Val Ala Phe Phe Ala Ser 
        835                 840                 845             


His Thr Tyr Gly Met Thr Ile Pro Gly Pro Ile Leu Phe Asn Asn Leu 
    850                 855                 860                 


Asp Val Asn Tyr Gly Ala Ser Tyr Thr Pro Arg Thr Gly Lys Phe Arg 
865                 870                 875                 880 


Ile Pro Tyr Leu Gly Val Tyr Val Phe Lys Tyr Thr Ile Glu Ser Phe 
                885                 890                 895     


Ser Ala His Ile Ser Gly Phe Leu Val Val Asp Gly Ile Asp Lys Leu 
            900                 905                 910         


Ala Phe Glu Ser Glu Asn Ile Asn Ser Glu Ile His Cys Asp Arg Val 
        915                 920                 925             


Leu Thr Gly Asp Ala Leu Leu Glu Leu Asn Tyr Gly Gln Glu Val Trp 
    930                 935                 940                 


Leu Arg Leu Ala Lys Gly Thr Ile Pro Ala Lys Phe Pro Pro Val Thr 
945                 950                 955                 960 


Thr Phe Ser Gly Tyr Leu Leu Tyr Arg Thr 
                965                 970 


<210>  8824
<211>  204
<212>  PRT
<213>  Homo Sapiens

<400>  8824

Met Ala His Lys Pro Val Tyr Gln Val Lys Gln Lys Val Leu Thr Ser 
1               5                   10                  15      


Leu Ala Trp Arg Cys Cys Pro Gly Tyr Thr Gly Pro Asn Cys Glu His 
            20                  25                  30          


His Asp Ser Met Ala Ile Pro Glu Pro Ala Asp Pro Gly Asp Ser His 
        35                  40                  45              


Gln Glu Pro Gln Asp Gly Pro Val Ser Phe Lys Pro Gly His Leu Ala 
    50                  55                  60                  


Ala Val Ile Asn Glu Val Glu Val Gln Gln Glu Gln Gln Glu His Leu 
65                  70                  75                  80  


Leu Gly Asp Leu Gln Asn Asp Val His Arg Val Ala Asp Ser Leu Pro 
                85                  90                  95      


Gly Leu Trp Lys Ala Leu Pro Gly Asn Leu Thr Ala Ala Val Met Glu 
            100                 105                 110         


Ala Asn Gln Thr Gly His Glu Phe Pro Asp Arg Ser Leu Glu Gln Val 
        115                 120                 125             


Leu Leu Pro His Val Asp Thr Phe Leu Gln Val His Phe Ser Pro Ile 
    130                 135                 140                 


Trp Arg Ser Phe Asn Gln Ser Leu His Ser Leu Thr Gln Ala Ile Arg 
145                 150                 155                 160 


Asn Leu Ser Leu Asp Val Glu Ala Asn Arg Gln Ala Ile Ser Arg Val 
                165                 170                 175     


Gln Asp Ser Ala Val Ala Arg Ala Asp Phe Gln Glu Leu Gly Ala Lys 
            180                 185                 190         


Phe Glu Ala Lys Val Gln Glu Asn Thr Gln Arg Val 
        195                 200                 


<210>  8825
<211>  295
<212>  PRT
<213>  Homo Sapiens

<400>  8825

Met Gly Thr Ser Ala Ser Trp Ala Gly Gly Met Gly Ile Lys Gly Gln 
1               5                   10                  15      


Pro Glu Ala Ala Lys Ser Trp Arg Lys Pro Lys Gln Ser Asn Trp Cys 
            20                  25                  30          


Pro Tyr Pro Met Ser Lys Leu Val Thr Leu Leu Ala Leu Cys Lys Thr 
        35                  40                  45              


Glu Lys Phe Leu Ile His Ser Gln Gln Pro Cys Pro Gln Gly Ala Pro 
    50                  55                  60                  


Asp Cys Gln Lys Val Lys Val Met Tyr Arg Met Ala His Lys Pro Val 
65                  70                  75                  80  


Tyr Gln Val Lys Gln Lys Val Leu Thr Ser Leu Ala Trp Arg Cys Cys 
                85                  90                  95      


Pro Gly Tyr Thr Gly Pro Asn Cys Glu His His Asp Ser Met Ala Ile 
            100                 105                 110         


Pro Glu Pro Ala Asp Pro Gly Asp Ser His Gln Glu Pro Gln Asp Gly 
        115                 120                 125             


Pro Val Ser Phe Lys Pro Gly His Leu Ala Ala Val Ile Asn Glu Val 
    130                 135                 140                 


Glu Val Gln Gln Glu Gln Gln Glu His Leu Leu Gly Asp Leu Gln Asn 
145                 150                 155                 160 


Asp Val His Arg Val Ala Asp Ser Leu Pro Gly Leu Trp Lys Ala Leu 
                165                 170                 175     


Pro Gly Asn Leu Thr Ala Ala Val Met Glu Ala Asn Gln Thr Gly His 
            180                 185                 190         


Glu Phe Pro Asp Arg Ser Leu Glu Gln Val Leu Leu Pro His Val Asp 
        195                 200                 205             


Thr Phe Leu Gln Val His Phe Ser Pro Ile Trp Arg Ser Phe Asn Gln 
    210                 215                 220                 


Ser Leu His Ser Leu Thr Gln Ala Ile Arg Asn Leu Ser Leu Asp Val 
225                 230                 235                 240 


Glu Ala Asn Arg Gln Ala Ile Ser Arg Val Gln Asp Ser Ala Val Ala 
                245                 250                 255     


Arg Ala Asp Phe Gln Glu Leu Gly Ala Lys Phe Glu Ala Lys Val Gln 
            260                 265                 270         


Glu Asn Thr Gln Arg Val Gly Gln Leu Arg Gln Asp Val Glu Asp Arg 
        275                 280                 285             


Leu His Ala Gln His Phe Thr 
    290                 295 


<210>  8826
<211>  109
<212>  PRT
<213>  Homo Sapiens

<400>  8826

Met Ile Leu Ser Leu Leu Phe Ser Leu Gly Gly Pro Leu Gly Trp Gly 
1               5                   10                  15      


Leu Leu Gly Ala Trp Ala Gln Ala Ser Ser Thr Ser Leu Ser Asp Leu 
            20                  25                  30          


Gln Ser Ser Arg Thr Pro Gly Val Trp Lys Ala Glu Ala Glu Asp Thr 
        35                  40                  45              


Gly Lys Asp Pro Val Gly Arg Ile Met Asp Ser Arg Ile Pro Ala Leu 
    50                  55                  60                  


Leu Arg Gln Glu Ala Arg Thr Gly Gly Ser Ala Leu Ala Pro Pro Val 
65                  70                  75                  80  


Asp Leu Gly Val Ala Gln Gln Pro Ser Pro Leu Ala Cys Phe Pro Val 
                85                  90                  95      


Thr Gly Ala Pro Thr Gln Cys Pro Ser Trp Ser Pro Tyr 
            100                 105                 


<210>  8827
<211>  949
<212>  PRT
<213>  Homo Sapiens

<400>  8827

Met Ile Leu Ser Leu Leu Phe Ser Leu Gly Gly Pro Leu Gly Trp Gly 
1               5                   10                  15      


Leu Leu Gly Ala Trp Ala Gln Ala Ser Ser Thr Ser Leu Ser Asp Leu 
            20                  25                  30          


Gln Ser Ser Arg Thr Pro Gly Val Trp Lys Ala Glu Ala Glu Asp Thr 
        35                  40                  45              


Gly Lys Asp Pro Val Gly Arg Asn Trp Cys Pro Tyr Pro Met Ser Lys 
    50                  55                  60                  


Leu Val Thr Leu Leu Ala Leu Cys Lys Thr Glu Lys Phe Leu Ile His 
65                  70                  75                  80  


Ser Gln Gln Pro Cys Pro Gln Gly Ala Pro Asp Cys Gln Lys Val Lys 
                85                  90                  95      


Val Met Tyr Arg Met Ala His Lys Pro Val Tyr Gln Val Lys Gln Lys 
            100                 105                 110         


Val Leu Thr Ser Leu Ala Trp Arg Cys Cys Pro Gly Tyr Thr Gly Pro 
        115                 120                 125             


Asn Cys Glu His His Asp Ser Met Ala Ile Pro Glu Pro Ala Asp Pro 
    130                 135                 140                 


Gly Asp Ser His Gln Glu Pro Gln Asp Gly Pro Val Ser Phe Lys Pro 
145                 150                 155                 160 


Gly His Leu Ala Ala Val Ile Asn Glu Val Glu Val Gln Gln Glu Gln 
                165                 170                 175     


Gln Glu His Leu Leu Gly Asp Leu Gln Asn Asp Val His Arg Val Ala 
            180                 185                 190         


Asp Ser Leu Pro Gly Leu Trp Lys Ala Leu Pro Gly Asn Leu Thr Ala 
        195                 200                 205             


Ala Val Met Glu Ala Asn Gln Thr Gly His Glu Phe Pro Asp Arg Ser 
    210                 215                 220                 


Leu Glu Gln Val Leu Leu Pro His Val Asp Thr Phe Leu Gln Val His 
225                 230                 235                 240 


Phe Ser Pro Ile Trp Arg Ser Phe Asn Gln Ser Leu His Ser Leu Thr 
                245                 250                 255     


Gln Ala Ile Arg Asn Leu Ser Leu Asp Val Glu Ala Asn Arg Gln Ala 
            260                 265                 270         


Ile Ser Arg Val Gln Asp Ser Ala Val Ala Arg Ala Asp Phe Gln Glu 
        275                 280                 285             


Leu Gly Ala Lys Phe Glu Ala Lys Val Gln Glu Asn Thr Gln Arg Val 
    290                 295                 300                 


Gly Gln Leu Arg Gln Asp Val Glu Asp Arg Leu His Ala Gln His Phe 
305                 310                 315                 320 


Thr Leu His Arg Ser Ile Ser Glu Leu Gln Ala Asp Val Asp Thr Lys 
                325                 330                 335     


Leu Lys Arg Leu His Lys Ala Gln Glu Ala Pro Gly Thr Asn Gly Ser 
            340                 345                 350         


Leu Val Leu Ala Thr Pro Gly Ala Gly Ala Arg Pro Glu Pro Asp Ser 
        355                 360                 365             


Leu Gln Ala Arg Leu Gly Gln Leu Gln Arg Asn Leu Ser Glu Leu His 
    370                 375                 380                 


Met Thr Thr Ala Arg Arg Glu Glu Glu Leu Gln Tyr Thr Leu Glu Asp 
385                 390                 395                 400 


Met Arg Ala Thr Leu Thr Arg His Val Asp Glu Ile Lys Glu Leu Tyr 
                405                 410                 415     


Ser Glu Ser Asp Glu Thr Phe Asp Gln Ile Ser Lys Val Glu Arg Gln 
            420                 425                 430         


Val Glu Glu Leu Gln Val Asn His Thr Ala Leu Arg Glu Leu Arg Val 
        435                 440                 445             


Ile Leu Met Glu Lys Ser Leu Ile Met Glu Glu Asn Lys Glu Glu Val 
    450                 455                 460                 


Glu Arg Gln Leu Leu Glu Leu Asn Leu Thr Leu Gln His Leu Gln Gly 
465                 470                 475                 480 


Gly His Ala Asp Leu Ile Lys Tyr Val Lys Asp Cys Asn Cys Gln Lys 
                485                 490                 495     


Leu Tyr Leu Asp Leu Asp Val Ile Arg Glu Gly Gln Arg Asp Ala Thr 
            500                 505                 510         


Arg Ala Leu Glu Glu Thr Gln Val Ser Leu Asp Glu Arg Arg Gln Leu 
        515                 520                 525             


Asp Gly Ser Ser Leu Gln Ala Leu Gln Asn Ala Val Asp Ala Val Ser 
    530                 535                 540                 


Leu Ala Val Asp Ala His Lys Ala Glu Gly Glu Arg Ala Arg Ala Ala 
545                 550                 555                 560 


Thr Ser Arg Leu Arg Ser Gln Val Gln Ala Leu Asp Asp Glu Val Gly 
                565                 570                 575     


Ala Leu Lys Ala Ala Ala Ala Glu Ala Arg His Glu Val Arg Gln Leu 
            580                 585                 590         


His Ser Ala Phe Ala Ala Leu Leu Glu Asp Ala Leu Arg His Glu Ala 
        595                 600                 605             


Val Leu Ala Ala Leu Phe Gly Glu Glu Val Leu Glu Glu Met Ser Glu 
    610                 615                 620                 


Gln Thr Pro Gly Pro Leu Pro Leu Ser Tyr Glu Gln Ile Arg Val Ala 
625                 630                 635                 640 


Leu Gln Asp Ala Ala Ser Gly Leu Gln Glu Gln Ala Leu Gly Trp Asp 
                645                 650                 655     


Glu Leu Ala Ala Arg Val Thr Ala Leu Glu Gln Ala Ser Glu Pro Pro 
            660                 665                 670         


Arg Pro Ala Glu His Leu Glu Pro Ser His Asp Ala Gly Arg Glu Glu 
        675                 680                 685             


Ala Ala Thr Thr Ala Leu Ala Gly Leu Ala Arg Glu Leu Gln Ser Leu 
    690                 695                 700                 


Ser Asn Asp Val Lys Asn Val Gly Arg Cys Cys Glu Ala Glu Ala Gly 
705                 710                 715                 720 


Ala Gly Ala Ala Ser Leu Asn Ala Ser Leu His Gly Leu His Asn Ala 
                725                 730                 735     


Leu Phe Ala Thr Gln Arg Ser Leu Glu Gln His Gln Arg Leu Phe His 
            740                 745                 750         


Ser Leu Phe Gly Asn Phe Gln Gly Leu Met Glu Ala Asn Val Ser Leu 
        755                 760                 765             


Asp Leu Gly Lys Leu Gln Thr Met Leu Ser Arg Lys Gly Lys Lys Gln 
    770                 775                 780                 


Gln Lys Asp Leu Glu Ala Pro Arg Lys Arg Asp Lys Lys Glu Ala Glu 
785                 790                 795                 800 


Pro Leu Val Asp Ile Arg Val Thr Gly Pro Val Pro Gly Ala Leu Gly 
                805                 810                 815     


Ala Ala Leu Trp Glu Ala Gly Ser Pro Val Ala Phe Tyr Ala Ser Phe 
            820                 825                 830         


Ser Glu Gly Thr Ala Ala Leu Gln Thr Val Lys Phe Asn Thr Thr Tyr 
        835                 840                 845             


Ile Asn Ile Gly Ser Ser Tyr Phe Pro Glu His Gly Tyr Phe Arg Ala 
    850                 855                 860                 


Pro Glu Arg Gly Val Tyr Leu Phe Ala Val Ser Val Glu Phe Gly Pro 
865                 870                 875                 880 


Gly Pro Gly Thr Gly Gln Leu Val Phe Gly Gly His His Arg Thr Pro 
                885                 890                 895     


Val Cys Thr Thr Gly Gln Gly Ser Gly Ser Thr Ala Thr Val Phe Ala 
            900                 905                 910         


Met Ala Glu Leu Gln Lys Gly Glu Arg Val Trp Phe Glu Leu Thr Gln 
        915                 920                 925             


Gly Ser Ile Thr Lys Arg Ser Leu Ser Gly Thr Ala Phe Gly Gly Phe 
    930                 935                 940                 


Leu Met Phe Lys Thr 
945                 


<210>  8828
<211>  123
<212>  PRT
<213>  Homo Sapiens

<400>  8828

Met Ser Lys Leu Val Thr Leu Leu Ala Leu Cys Lys Thr Glu Lys Phe 
1               5                   10                  15      


Leu Ile His Ser Gln Gln Pro Cys Pro Gln Gly Ala Pro Asp Cys Gln 
            20                  25                  30          


Lys Val Lys Val Met Tyr Arg Met Ala His Lys Pro Val Tyr Gln Val 
        35                  40                  45              


Lys Gln Lys Val Leu Thr Ser Leu Ala Trp Arg Cys Cys Pro Gly Tyr 
    50                  55                  60                  


Thr Gly Pro Asn Cys Glu His His Asp Ser Met Ala Ile Pro Glu Pro 
65                  70                  75                  80  


Ala Asp Pro Gly Asp Ser His Gln Glu Pro Gln Asp Gly Pro Val Ser 
                85                  90                  95      


Phe Lys Pro Gly His Leu Ala Ala Val Ile Asn Glu Val Glu Val Gln 
            100                 105                 110         


Gln Glu Gln Gln Glu His Leu Leu Gly Asp Leu 
        115                 120             


<210>  8829
<211>  613
<212>  PRT
<213>  Homo Sapiens

<400>  8829

Met Cys Cys Trp Pro Leu Leu Leu Leu Trp Gly Leu Leu Pro Gly Thr 
1               5                   10                  15      


Ala Ala Gly Gly Ser Gly Arg Thr Tyr Pro His Arg Thr Leu Leu Asp 
            20                  25                  30          


Ser Glu Gly Lys Tyr Trp Leu Gly Trp Ser Gln Arg Gly Ser Gln Ile 
        35                  40                  45              


Ala Phe Arg Leu Gln Val Arg Thr Ala Gly Tyr Val Gly Phe Gly Phe 
    50                  55                  60                  


Ser Pro Thr Gly Ala Met Ala Ser Ala Asp Ile Val Val Gly Gly Val 
65                  70                  75                  80  


Ala His Gly Arg Pro Tyr Leu Gln Asp Tyr Phe Thr Asn Ala Asn Arg 
                85                  90                  95      


Glu Leu Lys Lys Asp Ala Gln Gln Asp Tyr His Leu Glu Tyr Ala Met 
            100                 105                 110         


Glu Asn Ser Thr His Thr Ile Ile Glu Phe Thr Arg Glu Leu His Thr 
        115                 120                 125             


Cys Asp Ile Asn Asp Lys Ser Ile Thr Asp Ser Thr Val Arg Val Ile 
    130                 135                 140                 


Trp Ala Tyr His His Glu Asp Ala Gly Glu Ala Gly Pro Lys Tyr His 
145                 150                 155                 160 


Asp Ser Asn Arg Gly Thr Lys Ser Leu Arg Leu Leu Asn Pro Glu Lys 
                165                 170                 175     


Thr Ser Val Leu Ser Thr Ala Leu Pro Tyr Phe Asp Leu Val Asn Gln 
            180                 185                 190         


Asp Val Pro Ile Pro Asn Lys Asp Thr Thr Tyr Trp Cys Gln Met Phe 
        195                 200                 205             


Lys Ile Pro Val Phe Gln Glu Lys His His Val Ile Lys Val Glu Pro 
    210                 215                 220                 


Val Ile Gln Arg Gly His Glu Ser Leu Val His His Ile Leu Leu Tyr 
225                 230                 235                 240 


Gln Cys Ser Asn Asn Phe Asn Asp Ser Val Leu Glu Ser Gly His Glu 
                245                 250                 255     


Cys Tyr His Pro Asn Met Pro Asp Ala Phe Leu Thr Cys Glu Thr Val 
            260                 265                 270         


Ile Phe Ala Trp Ala Ile Gly Gly Glu Gly Phe Ser Tyr Pro Pro His 
        275                 280                 285             


Val Gly Leu Ser Leu Gly Thr Pro Leu Asp Pro His Tyr Val Leu Leu 
    290                 295                 300                 


Glu Val His Tyr Asp Asn Pro Thr Tyr Glu Glu Gly Leu Ile Asp Asn 
305                 310                 315                 320 


Ser Gly Leu Arg Leu Phe Tyr Thr Met Asp Ile Arg Lys Tyr Asp Ala 
                325                 330                 335     


Gly Val Ile Glu Ala Gly Leu Trp Val Ser Leu Phe His Thr Ile Pro 
            340                 345                 350         


Pro Gly Met Pro Glu Phe Gln Ser Glu Gly His Cys Thr Leu Glu Cys 
        355                 360                 365             


Leu Glu Glu Ala Leu Glu Ala Glu Lys Pro Ser Gly Ile His Val Phe 
    370                 375                 380                 


Ala Val Leu Leu His Ala His Leu Ala Gly Arg Gly Ile Arg Leu Arg 
385                 390                 395                 400 


His Phe Arg Lys Gly Lys Glu Met Lys Leu Leu Ala Tyr Asp Asp Asp 
                405                 410                 415     


Phe Asp Phe Asn Phe Gln Glu Phe Gln Tyr Leu Lys Glu Glu Gln Thr 
            420                 425                 430         


Ile Leu Pro Gly Asp Asn Leu Ile Thr Glu Cys Arg Tyr Asn Thr Lys 
        435                 440                 445             


Asp Arg Ala Glu Met Thr Trp Gly Gly Leu Ser Thr Arg Ser Glu Met 
    450                 455                 460                 


Cys Leu Ser Tyr Leu Leu Tyr Tyr Pro Arg Ile Asn Leu Thr Arg Cys 
465                 470                 475                 480 


Ala Ser Ile Pro Asp Ile Met Glu Gln Leu Gln Phe Ile Gly Val Lys 
                485                 490                 495     


Glu Ile Tyr Arg Pro Val Thr Thr Trp Pro Phe Ile Ile Lys Ser Pro 
            500                 505                 510         


Lys Gln Tyr Lys Asn Leu Ser Phe Met Asp Ala Met Asn Lys Phe Lys 
        515                 520                 525             


Trp Thr Lys Lys Glu Gly Leu Ser Phe Asn Lys Leu Val Leu Ser Leu 
    530                 535                 540                 


Pro Val Asn Val Arg Cys Ser Lys Thr Asp Asn Ala Glu Trp Ser Ile 
545                 550                 555                 560 


Gln Gly Met Thr Ala Leu Pro Pro Asp Ile Glu Arg Pro Tyr Lys Ala 
                565                 570                 575     


Glu Pro Leu Val Cys Gly Thr Ser Ser Ser Ser Ser Leu His Arg Asp 
            580                 585                 590         


Phe Ser Ile Asn Leu Leu Val Cys Leu Leu Leu Leu Ser Cys Thr Leu 
        595                 600                 605             


Ser Thr Lys Ser Leu 
    610             


<210>  8830
<211>  115
<212>  PRT
<213>  Homo Sapiens

<400>  8830

Met Cys Cys Trp Pro Leu Leu Leu Leu Trp Gly Leu Leu Pro Gly Thr 
1               5                   10                  15      


Ala Ala Gly Gly Ser Gly Arg Thr Tyr Pro His Arg Thr Leu Leu Asp 
            20                  25                  30          


Ser Glu Gly Lys Tyr Trp Leu Gly Trp Ser Gln Arg Gly Ser Gln Ile 
        35                  40                  45              


Ala Phe Arg Leu Gln Val Arg Thr Ala Gly Tyr Val Gly Phe Gly Phe 
    50                  55                  60                  


Ser Pro Thr Gly Ala Met Ala Ser Ala Asp Ile Val Val Gly Gly Val 
65                  70                  75                  80  


Ala His Gly Arg Pro Tyr Leu Gln Pro Cys Leu Leu Val Ser Lys Thr 
                85                  90                  95      


Glu Ala Cys Asp Ala Lys Cys Leu Gln Gln Gln Gly Asn Cys Cys Arg 
            100                 105                 110         


Ala Thr Cys 
        115 


<210>  8831
<211>  545
<212>  PRT
<213>  Homo Sapiens

<400>  8831

Met Asn Ser Phe Leu Ser Val Phe Arg Tyr Pro Asp Phe Ser Phe Pro 
1               5                   10                  15      


Tyr Phe Pro Gln Asp Tyr Phe Thr Asn Ala Asn Arg Glu Leu Lys Lys 
            20                  25                  30          


Asp Ala Gln Gln Asp Tyr His Leu Glu Tyr Ala Met Glu Asn Ser Thr 
        35                  40                  45              


His Thr Ile Ile Glu Phe Thr Arg Glu Leu His Thr Cys Asp Ile Asn 
    50                  55                  60                  


Asp Lys Ser Ile Thr Asp Ser Thr Val Arg Val Ile Trp Ala Tyr His 
65                  70                  75                  80  


His Glu Asp Ala Gly Glu Ala Gly Pro Lys Tyr His Asp Ser Asn Arg 
                85                  90                  95      


Gly Thr Lys Ser Leu Arg Leu Leu Asn Pro Glu Lys Thr Ser Val Leu 
            100                 105                 110         


Ser Thr Ala Leu Pro Tyr Phe Asp Leu Val Asn Gln Asp Val Pro Ile 
        115                 120                 125             


Pro Asn Lys Asp Thr Thr Tyr Trp Cys Gln Met Phe Lys Ile Pro Val 
    130                 135                 140                 


Phe Gln Glu Lys His His Val Ile Lys Val Glu Pro Val Ile Gln Arg 
145                 150                 155                 160 


Gly His Glu Ser Leu Val His His Ile Leu Leu Tyr Gln Cys Ser Asn 
                165                 170                 175     


Asn Phe Asn Asp Ser Val Leu Glu Ser Gly His Glu Cys Tyr His Pro 
            180                 185                 190         


Asn Met Pro Asp Ala Phe Leu Thr Cys Glu Thr Val Ile Phe Ala Trp 
        195                 200                 205             


Ala Ile Gly Gly Glu Gly Phe Ser Tyr Pro Pro His Val Gly Leu Ser 
    210                 215                 220                 


Leu Gly Thr Pro Leu Asp Pro His Tyr Val Leu Leu Glu Val His Tyr 
225                 230                 235                 240 


Asp Asn Pro Thr Tyr Glu Glu Gly Leu Ile Asp Asn Ser Gly Leu Arg 
                245                 250                 255     


Leu Phe Tyr Thr Met Asp Ile Arg Lys Tyr Asp Ala Gly Val Ile Glu 
            260                 265                 270         


Ala Gly Leu Trp Val Ser Leu Phe His Thr Ile Pro Pro Gly Met Pro 
        275                 280                 285             


Glu Phe Gln Ser Glu Gly His Cys Thr Leu Glu Cys Leu Glu Glu Ala 
    290                 295                 300                 


Leu Glu Ala Glu Lys Pro Ser Gly Ile His Val Phe Ala Val Leu Leu 
305                 310                 315                 320 


His Ala His Leu Ala Gly Arg Gly Ile Arg Leu Arg His Phe Arg Lys 
                325                 330                 335     


Gly Lys Glu Met Lys Leu Leu Ala Tyr Asp Asp Asp Phe Asp Phe Asn 
            340                 345                 350         


Phe Gln Glu Phe Gln Tyr Leu Lys Glu Glu Gln Thr Ile Leu Pro Gly 
        355                 360                 365             


Asp Asn Leu Ile Thr Glu Cys Arg Tyr Asn Thr Lys Asp Arg Ala Glu 
    370                 375                 380                 


Met Thr Trp Gly Gly Leu Ser Thr Arg Ser Glu Met Cys Leu Ser Tyr 
385                 390                 395                 400 


Leu Leu Tyr Tyr Pro Arg Ile Asn Leu Thr Arg Cys Ala Ser Ile Pro 
                405                 410                 415     


Asp Ile Met Glu Gln Leu Gln Phe Ile Gly Val Lys Glu Ile Tyr Arg 
            420                 425                 430         


Pro Val Thr Thr Trp Pro Phe Ile Ile Lys Ser Pro Lys Gln Tyr Lys 
        435                 440                 445             


Asn Leu Ser Phe Met Asp Ala Met Asn Lys Phe Lys Trp Thr Lys Lys 
    450                 455                 460                 


Glu Gly Leu Ser Phe Asn Lys Leu Val Leu Ser Leu Pro Val Asn Val 
465                 470                 475                 480 


Arg Cys Ser Lys Thr Asp Asn Ala Glu Trp Ser Ile Gln Gly Met Thr 
                485                 490                 495     


Ala Leu Pro Pro Asp Ile Glu Arg Pro Tyr Lys Ala Glu Pro Leu Val 
            500                 505                 510         


Cys Gly Thr Ser Ser Ser Ser Ser Leu His Arg Asp Phe Ser Ile Asn 
        515                 520                 525             


Leu Leu Val Cys Leu Leu Leu Leu Ser Cys Thr Leu Ser Thr Lys Ser 
    530                 535                 540                 


Leu 
545 


<210>  8832
<211>  125
<212>  PRT
<213>  Homo Sapiens

<400>  8832

Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln 
1               5                   10                  15      


Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn 
            20                  25                  30          


Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro 
        35                  40                  45              


Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu 
    50                  55                  60                  


Trp Ala Ser Ser Ser Gly Thr Pro Thr Val Pro Pro Leu Gln Pro Phe 
65                  70                  75                  80  


Val Gly Arg Leu Arg Ser Leu Asp Ser Ala Pro Asp Pro Ala Ala Gly 
                85                  90                  95      


Arg Trp Val Gly Ala Arg Thr Gly Ser Phe Gly Pro Gly Leu Val Ala 
            100                 105                 110         


Ala Gln Ala Pro Ala Pro Ala Thr Asp Ser Thr Thr Pro 
        115                 120                 125 


<210>  8833
<211>  193
<212>  PRT
<213>  Homo Sapiens

<400>  8833

Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln 
1               5                   10                  15      


Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn 
            20                  25                  30          


Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro 
        35                  40                  45              


Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu 
    50                  55                  60                  


Trp Ala Ser Ser Ser Gly Thr Pro Thr Val Pro Pro Leu Gln Pro Phe 
65                  70                  75                  80  


Val Gly Arg Leu Arg Ser Leu Asp Ser Gly Ile Arg Arg Leu Glu Leu 
                85                  90                  95      


Leu Leu Ser Ala Gly Asp Ser Gly Thr Phe Phe Cys Lys Gly Arg His 
            100                 105                 110         


Glu Asp Glu Ser Arg Thr Val Leu His Val Leu Gly Asp Arg Thr Tyr 
        115                 120                 125             


Cys Lys Ala Pro Gly Pro Thr His Ala Leu Ser Pro Pro His Ser Ser 
    130                 135                 140                 


Thr Cys Glu Asn Arg Ala Pro Glu Ala Ser Lys Gly Gly Arg Ala Gln 
145                 150                 155                 160 


Asp Ser Arg Gly Pro Gly Pro Gly Thr Glu Pro Ala Leu Cys Gly Ser 
                165                 170                 175     


Gly Pro Ser Ser Pro Gln Gln Ala Pro Pro Ala Val His Ser Gly Pro 
            180                 185                 190         


Cys 
    


<210>  8834
<211>  197
<212>  PRT
<213>  Homo Sapiens

<400>  8834

Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln 
1               5                   10                  15      


Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn 
            20                  25                  30          


Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro 
        35                  40                  45              


Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu 
    50                  55                  60                  


Trp Ala Ser Ser Ser Gly Thr Pro Thr Val Pro Pro Leu Gln Pro Phe 
65                  70                  75                  80  


Val Gly Arg Leu Arg Ser Leu Asp Ser Gly Ile Arg Arg Leu Glu Leu 
                85                  90                  95      


Leu Leu Ser Ala Gly Asp Ser Gly Thr Phe Phe Cys Lys Gly Arg His 
            100                 105                 110         


Glu Asp Glu Ser Arg Thr Val Leu His Val Leu Gly Asp Arg Thr Tyr 
        115                 120                 125             


Cys Lys Ala Pro Gly Pro Thr His Ala Pro Leu Val Lys Thr Glu Pro 
    130                 135                 140                 


Gln Arg Pro Val Lys Glu Glu Glu Pro Lys Ile Pro Gly Asp Leu Asp 
145                 150                 155                 160 


Gln Glu Pro Ser Leu Leu Tyr Ala Asp Leu Asp His Leu Ala Leu Ser 
                165                 170                 175     


Arg Pro Arg Arg Leu Ser Thr Ala Asp Pro Ala Asp Ala Ser Thr Ile 
            180                 185                 190         


Tyr Ala Val Val Val 
        195         


<210>  8835
<211>  217
<212>  PRT
<213>  Homo Sapiens

<400>  8835

Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln 
1               5                   10                  15      


Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn 
            20                  25                  30          


Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro 
        35                  40                  45              


Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu 
    50                  55                  60                  


Trp Ala Ser Ser Ser Gly Thr Pro Thr Val Pro Pro Leu Gln Pro Phe 
65                  70                  75                  80  


Val Gly Arg Leu Arg Ser Leu Asp Ser Gly Ile Arg Arg Leu Glu Leu 
                85                  90                  95      


Leu Leu Ser Ala Gly Asp Ser Gly Thr Phe Phe Cys Lys Gly Arg His 
            100                 105                 110         


Glu Asp Glu Ser Arg Thr Val Leu His Val Leu Gly Asp Arg Thr Tyr 
        115                 120                 125             


Cys Lys Ala Pro Gly Pro Thr His Gly Ala Cys Pro Arg Asn Arg Phe 
    130                 135                 140                 


Asp His Ser Leu Asp Leu Leu Cys Pro Pro His Ile Ala Pro Leu Val 
145                 150                 155                 160 


Lys Thr Glu Pro Gln Arg Pro Val Lys Glu Glu Glu Pro Lys Ile Pro 
                165                 170                 175     


Gly Asp Leu Asp Gln Glu Pro Ser Leu Leu Tyr Ala Asp Leu Asp His 
            180                 185                 190         


Leu Ala Leu Ser Arg Pro Arg Arg Leu Ser Thr Ala Asp Pro Ala Asp 
        195                 200                 205             


Ala Ser Thr Ile Tyr Ala Val Val Val 
    210                 215         


<210>  8836
<211>  237
<212>  PRT
<213>  Homo Sapiens

<400>  8836

Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln 
1               5                   10                  15      


Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn 
            20                  25                  30          


Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro 
        35                  40                  45              


Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu 
    50                  55                  60                  


Trp Ala Ser Ser Ser Gly Thr Pro Thr Val Pro Pro Leu Gln Pro Phe 
65                  70                  75                  80  


Val Gly Arg Leu Arg Ser Leu Asp Ser Gly Ile Arg Arg Leu Glu Leu 
                85                  90                  95      


Leu Leu Ser Ala Gly Asp Ser Gly Thr Phe Phe Cys Lys Gly Arg His 
            100                 105                 110         


Glu Asp Glu Ser Arg Thr Val Leu His Val Leu Gly Asp Arg Thr Tyr 
        115                 120                 125             


Cys Lys Ala Pro Gly Pro Thr His Gly Ser Val Tyr Pro Gln Leu Leu 
    130                 135                 140                 


Ile Pro Leu Leu Gly Ala Gly Leu Val Leu Gly Leu Gly Ala Leu Gly 
145                 150                 155                 160 


Leu Val Trp Trp Leu His Arg Arg Leu Pro Pro Gln Pro Ile Arg Pro 
                165                 170                 175     


Leu Pro Arg Phe Ala Leu Ser Pro Pro His Ser Ser Thr Cys Glu Asn 
            180                 185                 190         


Arg Ala Pro Glu Ala Ser Lys Gly Gly Arg Ala Gln Asp Ser Arg Gly 
        195                 200                 205             


Pro Gly Pro Gly Thr Glu Pro Ala Leu Cys Gly Ser Gly Pro Ser Ser 
    210                 215                 220                 


Pro Gln Gln Ala Pro Pro Ala Val His Ser Gly Pro Cys 
225                 230                 235         


<210>  8837
<211>  222
<212>  PRT
<213>  Homo Sapiens

<400>  8837

Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln 
1               5                   10                  15      


Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn 
            20                  25                  30          


Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro 
        35                  40                  45              


Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu 
    50                  55                  60                  


Trp Ala Ser Ser Ser Gly Thr Pro Thr Val Pro Pro Leu Gln Pro Phe 
65                  70                  75                  80  


Val Gly Arg Leu Arg Ser Leu Asp Ser Gly Ile Arg Arg Leu Glu Leu 
                85                  90                  95      


Leu Leu Ser Ala Gly Asp Ser Gly Thr Phe Phe Cys Lys Gly Arg His 
            100                 105                 110         


Glu Asp Glu Ser Arg Thr Val Leu His Val Leu Gly Asp Arg Thr Tyr 
        115                 120                 125             


Cys Lys Ala Pro Gly Pro Thr His Gly Ser Val Tyr Pro Gln Leu Leu 
    130                 135                 140                 


Ile Pro Leu Leu Gly Ala Gly Leu Val Leu Gly Leu Gly Ala Leu Gly 
145                 150                 155                 160 


Leu Val Trp Trp Leu His Arg Arg Leu Pro Pro Gln Pro Ile Arg Pro 
                165                 170                 175     


Leu Pro Arg Phe Ala Leu Ser Pro Pro His Ser Ser Thr Cys Glu Asn 
            180                 185                 190         


Arg Ala Pro Glu Ala Ser Lys Gly Gly Arg Ala Gln Asp Ser Arg Gly 
        195                 200                 205             


Pro Gly Pro Gly Thr Gly Lys Gly Met Gly Met Gly Arg Gly 
    210                 215                 220         


<210>  8838
<211>  241
<212>  PRT
<213>  Homo Sapiens

<400>  8838

Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln 
1               5                   10                  15      


Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn 
            20                  25                  30          


Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro 
        35                  40                  45              


Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu 
    50                  55                  60                  


Trp Ala Ser Ser Ser Gly Thr Pro Thr Val Pro Pro Leu Gln Pro Phe 
65                  70                  75                  80  


Val Gly Arg Leu Arg Ser Leu Asp Ser Gly Ile Arg Arg Leu Glu Leu 
                85                  90                  95      


Leu Leu Ser Ala Gly Asp Ser Gly Thr Phe Phe Cys Lys Gly Arg His 
            100                 105                 110         


Glu Asp Glu Ser Arg Thr Val Leu His Val Leu Gly Asp Arg Thr Tyr 
        115                 120                 125             


Cys Lys Ala Pro Gly Pro Thr His Gly Ser Val Tyr Pro Gln Leu Leu 
    130                 135                 140                 


Ile Pro Leu Leu Gly Ala Gly Leu Val Leu Gly Leu Gly Ala Leu Gly 
145                 150                 155                 160 


Leu Val Trp Trp Leu His Arg Arg Leu Pro Pro Gln Pro Ile Arg Pro 
                165                 170                 175     


Leu Pro Arg Phe Ala Pro Leu Val Lys Thr Glu Pro Gln Arg Pro Val 
            180                 185                 190         


Lys Glu Glu Glu Pro Lys Ile Pro Gly Asp Leu Asp Gln Glu Pro Ser 
        195                 200                 205             


Leu Leu Tyr Ala Asp Leu Asp His Leu Ala Leu Ser Arg Pro Arg Arg 
    210                 215                 220                 


Leu Ser Thr Ala Asp Pro Ala Asp Ala Ser Thr Ile Tyr Ala Val Val 
225                 230                 235                 240 


Val 
    


<210>  8839
<211>  220
<212>  PRT
<213>  Homo Sapiens

<400>  8839

Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln 
1               5                   10                  15      


Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn 
            20                  25                  30          


Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro 
        35                  40                  45              


Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu 
    50                  55                  60                  


Trp Ala Ser Ser Ser Gly Thr Pro Thr Val Pro Pro Leu Gln Pro Phe 
65                  70                  75                  80  


Val Gly Arg Leu Arg Ser Leu Asp Ser Gly Ile Arg Arg Leu Glu Leu 
                85                  90                  95      


Leu Leu Ser Ala Gly Asp Ser Gly Thr Phe Phe Cys Lys Gly Arg His 
            100                 105                 110         


Glu Asp Glu Ser Arg Thr Val Leu His Val Leu Gly Asp Arg Thr Tyr 
        115                 120                 125             


Cys Lys Ala Pro Gly Pro Thr His Gly Ser Val Tyr Pro Gln Leu Leu 
    130                 135                 140                 


Ile Pro Leu Leu Gly Ala Gly Leu Val Leu Gly Leu Gly Ala Leu Gly 
145                 150                 155                 160 


Leu Val Trp Trp Leu His Arg Arg Leu Pro Pro Gln Pro Ile Arg Pro 
                165                 170                 175     


Leu Pro Arg Phe Ala Pro Leu Val Lys Thr Glu Pro Gln Arg Pro Val 
            180                 185                 190         


Lys Glu Glu Glu Pro Lys Ile Pro Gly Asp Leu Asp Gln Glu Pro Val 
        195                 200                 205             


Arg Ala Trp Gly Trp Glu Gly Asp Ser Gln Asn Leu 
    210                 215                 220 


<210>  8840
<211>  745
<212>  PRT
<213>  Homo Sapiens

<400>  8840

Met Gly Val Pro Phe Phe Ser Ser Leu Arg Cys Met Val Asp Leu Gly 
1               5                   10                  15      


Pro Cys Trp Ala Gly Gly Leu Thr Ala Glu Met Lys Leu Leu Leu Ala 
            20                  25                  30          


Leu Ala Gly Leu Leu Ala Ile Leu Ala Thr Pro Gln Pro Ser Glu Gly 
        35                  40                  45              


Ala Ala Pro Ala Val Leu Gly Glu Val Asp Thr Ser Leu Val Leu Ser 
    50                  55                  60                  


Ser Met Glu Glu Ala Lys Gln Leu Val Asp Lys Ala Tyr Lys Glu Arg 
65                  70                  75                  80  


Arg Glu Ser Ile Lys Gln Arg Leu Arg Ser Gly Ser Ala Ser Pro Met 
                85                  90                  95      


Glu Leu Leu Ser Tyr Phe Lys Gln Pro Val Ala Ala Thr Arg Thr Ala 
            100                 105                 110         


Val Arg Ala Ala Asp Tyr Leu His Val Ala Leu Asp Leu Leu Glu Arg 
        115                 120                 125             


Lys Leu Arg Ser Leu Trp Arg Arg Pro Phe Asn Val Thr Asp Val Leu 
    130                 135                 140                 


Thr Pro Ala Gln Leu Asn Val Leu Ser Lys Ser Ser Gly Cys Ala Tyr 
145                 150                 155                 160 


Gln Asp Val Gly Val Thr Cys Pro Glu Gln Asp Lys Tyr Arg Thr Ile 
                165                 170                 175     


Thr Gly Met Cys Asn Asn Arg Arg Ser Pro Thr Leu Gly Ala Ser Asn 
            180                 185                 190         


Arg Ala Phe Val Arg Trp Leu Pro Ala Glu Tyr Glu Asp Gly Phe Ser 
        195                 200                 205             


Leu Pro Tyr Gly Trp Thr Pro Gly Val Lys Arg Asn Gly Phe Pro Val 
    210                 215                 220                 


Ala Leu Ala Arg Ala Val Ser Asn Glu Ile Val Arg Phe Pro Thr Asp 
225                 230                 235                 240 


Gln Leu Thr Pro Asp Gln Glu Arg Ser Leu Met Phe Met Gln Trp Gly 
                245                 250                 255     


Gln Leu Leu Asp His Asp Leu Asp Phe Thr Pro Glu Pro Ala Ala Arg 
            260                 265                 270         


Ala Ser Phe Val Thr Gly Val Asn Cys Glu Thr Ser Cys Val Gln Gln 
        275                 280                 285             


Pro Pro Cys Phe Pro Leu Lys Ile Pro Pro Asn Asp Pro Arg Ile Lys 
    290                 295                 300                 


Asn Gln Ala Asp Cys Ile Pro Phe Phe Arg Ser Cys Pro Ala Cys Pro 
305                 310                 315                 320 


Gly Ser Asn Ile Thr Ile Arg Asn Gln Ile Asn Ala Leu Thr Ser Phe 
                325                 330                 335     


Val Asp Ala Ser Met Val Tyr Gly Ser Glu Glu Pro Leu Ala Arg Asn 
            340                 345                 350         


Leu Arg Asn Met Ser Asn Gln Leu Gly Leu Leu Ala Val Asn Gln Arg 
        355                 360                 365             


Phe Gln Asp Asn Gly Arg Ala Leu Leu Pro Phe Asp Asn Leu His Asp 
    370                 375                 380                 


Asp Pro Cys Leu Leu Thr Asn Arg Ser Ala Arg Ile Pro Cys Phe Leu 
385                 390                 395                 400 


Ala Gly Asp Thr Arg Ser Ser Glu Met Pro Glu Leu Thr Ser Met His 
                405                 410                 415     


Thr Leu Leu Leu Arg Glu His Asn Arg Leu Ala Thr Glu Leu Lys Ser 
            420                 425                 430         


Leu Asn Pro Arg Trp Asp Gly Glu Arg Leu Tyr Gln Glu Ala Arg Lys 
        435                 440                 445             


Ile Val Gly Ala Met Val Gln Ile Ile Thr Tyr Arg Asp Tyr Leu Pro 
    450                 455                 460                 


Leu Val Leu Gly Pro Thr Ala Met Arg Lys Tyr Leu Pro Thr Tyr Arg 
465                 470                 475                 480 


Ser Tyr Asn Asp Ser Val Asp Pro Arg Ile Ala Asn Val Phe Thr Asn 
                485                 490                 495     


Ala Phe Arg Tyr Gly His Thr Leu Ile Gln Pro Phe Met Phe Arg Leu 
            500                 505                 510         


Asp Asn Arg Tyr Gln Pro Met Glu Pro Asn Pro Arg Val Pro Leu Ser 
        515                 520                 525             


Arg Val Phe Phe Ala Ser Trp Arg Val Val Leu Glu Gly Gly Ile Asp 
    530                 535                 540                 


Pro Ile Leu Arg Gly Leu Met Ala Thr Pro Ala Lys Leu Asn Arg Gln 
545                 550                 555                 560 


Asn Gln Ile Ala Val Asp Glu Ile Arg Glu Arg Leu Phe Glu Gln Val 
                565                 570                 575     


Met Arg Ile Gly Leu Asp Leu Pro Ala Leu Asn Met Gln Arg Ser Arg 
            580                 585                 590         


Asp His Gly Leu Pro Gly Tyr Asn Ala Trp Arg Arg Phe Cys Gly Leu 
        595                 600                 605             


Pro Gln Pro Glu Thr Val Gly Gln Leu Gly Thr Val Leu Arg Asn Leu 
    610                 615                 620                 


Lys Leu Ala Arg Lys Leu Met Glu Gln Tyr Gly Thr Pro Asn Asn Ile 
625                 630                 635                 640 


Asp Ile Trp Met Gly Gly Val Ser Glu Pro Leu Lys Arg Lys Gly Arg 
                645                 650                 655     


Val Gly Pro Leu Leu Ala Cys Ile Ile Gly Thr Gln Phe Arg Lys Leu 
            660                 665                 670         


Arg Asp Gly Asp Arg Phe Trp Trp Glu Asn Glu Gly Val Phe Ser Met 
        675                 680                 685             


Gln Gln Arg Gln Ala Leu Ala Gln Ile Ser Leu Pro Arg Ile Ile Cys 
    690                 695                 700                 


Asp Asn Thr Gly Ile Thr Thr Val Ser Lys Asn Asn Ile Phe Met Ser 
705                 710                 715                 720 


Asn Ser Tyr Pro Arg Asp Phe Val Asn Cys Ser Thr Leu Pro Ala Leu 
                725                 730                 735     


Asn Leu Ala Ser Trp Arg Glu Ala Ser 
            740                 745 


<210>  8841
<211>  87
<212>  PRT
<213>  Homo Sapiens

<400>  8841

Arg Tyr Gln Pro Met Glu Pro Asn Pro Arg Val Pro Leu Ser Arg Val 
1               5                   10                  15      


Phe Phe Ala Ser Trp Arg Val Val Leu Glu Gly Gly Ile Asp Pro Ile 
            20                  25                  30          


Leu Arg Gly Leu Met Ala Thr Pro Ala Lys Leu Asn Arg Gln Asn Gln 
        35                  40                  45              


Ile Ala Val Asp Glu Ile Arg Glu Arg Leu Phe Glu Gln Ile Ser Leu 
    50                  55                  60                  


Pro Arg Ile Ile Cys Asp Asn Thr Gly Ile Thr Thr Val Ser Lys Asn 
65                  70                  75                  80  


Asn Ile Phe Met Ser Asn Ser 
                85          


<210>  8842
<211>  74
<212>  PRT
<213>  Homo Sapiens

<400>  8842

Met Trp Arg Ser Arg Trp Asp Ala Ser Val Leu Lys Ala Glu Ala Leu 
1               5                   10                  15      


Ala Leu Leu Pro Cys Gly Leu Gly Met Ala Phe Ser Gln Ser His Val 
            20                  25                  30          


Met Ala Ala Arg Arg His Gln His Ser Arg Leu Ile Ile Glu Val Asp 
        35                  40                  45              


Glu Tyr Ser Ser Asn Pro Thr Gln Ala Phe Thr Phe Tyr Asn Ile Asn 
    50                  55                  60                  


Gln Gly Arg Phe Gln Pro Pro His Val Gln 
65                  70                  


<210>  8843
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  8843

Met Trp Arg Ser Arg Trp Asp Ala Ser Val Leu Lys Ala Glu Ala Leu 
1               5                   10                  15      


Ala Leu Leu Pro Cys Gly Leu Gly Met Ala Phe Ser Gln Ser His Val 
            20                  25                  30          


Met Ala Ala Arg Arg His Gln His Ser Arg Leu Ile Ile Glu Val Asp 
        35                  40                  45              


Glu Tyr Ser Ser Asn Pro Thr Gln Ala Phe Thr Phe Tyr Asn Ile Asn 
    50                  55                  60                  


Gln Gly Arg Phe Gln Pro Pro His Val Gln Met Val Asp Pro Val Pro 
65                  70                  75                  80  


His Asp Ala Pro Lys Pro Pro Gly Tyr Thr Arg Phe Val Cys Val Ser 
                85                  90                  95      


Asp Thr His Ser Arg Thr Asp Pro Ile Gln Met Pro Tyr Gly Asp Val 
            100                 105                 110         


Leu Ile His Ala Gly Asp Phe 
        115                 


<210>  8844
<211>  326
<212>  PRT
<213>  Homo Sapiens

<400>  8844

Met Trp Arg Ser Arg Trp Asp Ala Ser Val Leu Lys Ala Glu Ala Leu 
1               5                   10                  15      


Ala Leu Leu Pro Cys Gly Leu Gly Met Ala Phe Ser Gln Ser His Val 
            20                  25                  30          


Met Ala Ala Arg Arg His Gln His Ser Arg Leu Ile Ile Glu Val Asp 
        35                  40                  45              


Glu Tyr Ser Ser Asn Pro Thr Gln Ala Phe Thr Phe Tyr Asn Ile Asn 
    50                  55                  60                  


Gln Gly Arg Phe Gln Pro Pro His Val Gln Met Val Asp Pro Val Pro 
65                  70                  75                  80  


His Asp Ala Pro Lys Pro Pro Gly Tyr Thr Arg Phe Val Cys Val Ser 
                85                  90                  95      


Asp Thr His Ser Arg Thr Asp Pro Ile Gln Met Pro Tyr Gly Asp Val 
            100                 105                 110         


Leu Ile His Ala Gly Asp Phe Thr Glu Leu Gly Leu Pro Ser Glu Val 
        115                 120                 125             


Lys Lys Phe Asn Glu Trp Leu Gly Ser Leu Pro Tyr Glu Tyr Lys Ile 
    130                 135                 140                 


Val Ile Ala Gly Asn His Glu Leu Thr Phe Asp Gln Glu Phe Met Ala 
145                 150                 155                 160 


Asp Leu Ile Lys Gln Asp Phe Tyr Tyr Phe Pro Ser Val Ser Lys Leu 
                165                 170                 175     


Lys Pro Glu Asn Tyr Glu Asn Val Gln Ser Leu Leu Thr Asn Cys Ile 
            180                 185                 190         


Tyr Leu Gln Asp Ser Glu Val Thr Val Arg Gly Phe Arg Ile Tyr Gly 
        195                 200                 205             


Ser Pro Trp Gln Pro Trp Phe Tyr Gly Trp Gly Phe Asn Leu Pro Arg 
    210                 215                 220                 


Gly Gln Ala Leu Leu Glu Lys Trp Asn Leu Ile Pro Glu Gly Val Asp 
225                 230                 235                 240 


Ile Leu Ile Thr His Gly Pro Pro Leu Gly Phe Leu Asp Trp Val Pro 
                245                 250                 255     


Lys Lys Met Gln Arg Val Gly Cys Val Glu Leu Leu Asn Thr Val Gln 
            260                 265                 270         


Arg Arg Val Gln Pro Arg Leu His Val Phe Gly His Ile His Glu Gly 
        275                 280                 285             


Tyr Gly Val Met Ala Asp Gly Thr Thr Thr Tyr Val Asn Ala Ser Val 
    290                 295                 300                 


Cys Thr Val Asn Tyr Gln Pro Val Asn Pro Pro Ile Val Ile Asp Leu 
305                 310                 315                 320 


Pro Thr Pro Arg Asn Ser 
                325     


<210>  8845
<211>  326
<212>  PRT
<213>  Homo Sapiens

<400>  8845

Met Trp Arg Ser Arg Trp Asp Ala Ser Val Leu Lys Ala Glu Ala Leu 
1               5                   10                  15      


Ala Leu Leu Pro Cys Gly Leu Gly Met Ala Phe Ser Gln Ser His Val 
            20                  25                  30          


Met Ala Ala Arg Arg His Gln His Ser Arg Leu Ile Ile Glu Val Asp 
        35                  40                  45              


Glu Tyr Ser Ser Asn Pro Thr Gln Ala Phe Thr Phe Tyr Asn Ile Asn 
    50                  55                  60                  


Gln Gly Arg Phe Gln Pro Pro His Val Gln Met Val Asp Pro Val Pro 
65                  70                  75                  80  


His Asp Ala Pro Lys Pro Pro Gly Tyr Thr Arg Phe Val Cys Val Ser 
                85                  90                  95      


Asp Thr His Ser Arg Thr Asp Pro Ile Gln Met Pro Tyr Gly Asp Val 
            100                 105                 110         


Leu Ile His Ala Gly Asp Phe Thr Glu Leu Gly Leu Pro Ser Glu Val 
        115                 120                 125             


Lys Lys Phe Asn Glu Trp Leu Gly Ser Leu Pro Tyr Glu Tyr Lys Ile 
    130                 135                 140                 


Val Ile Ala Gly Asn His Glu Leu Thr Phe Asp Gln Glu Phe Met Ala 
145                 150                 155                 160 


Asp Leu Ile Lys Gln Asp Phe Tyr Tyr Phe Pro Ser Val Ser Lys Leu 
                165                 170                 175     


Lys Pro Glu Asn Tyr Glu Asn Val Gln Ser Leu Leu Thr Asn Cys Ile 
            180                 185                 190         


Tyr Leu Gln Asp Ser Glu Val Thr Val Arg Gly Phe Arg Ile Tyr Gly 
        195                 200                 205             


Ser Pro Trp Gln Pro Trp Phe Tyr Gly Trp Gly Phe Asn Leu Pro Arg 
    210                 215                 220                 


Gly Gln Ala Leu Leu Glu Lys Trp Asn Leu Ile Pro Glu Gly Val Asp 
225                 230                 235                 240 


Ile Leu Ile Thr His Gly Pro Pro Leu Gly Phe Leu Asp Trp Val Pro 
                245                 250                 255     


Lys Lys Met Gln Arg Val Gly Cys Val Glu Leu Leu Asn Thr Val Gln 
            260                 265                 270         


Arg Arg Val Gln Pro Arg Leu His Val Phe Gly His Ile His Glu Gly 
        275                 280                 285             


Tyr Gly Val Met Ala Asp Gly Thr Thr Thr Tyr Val Asn Ala Ser Val 
    290                 295                 300                 


Cys Thr Val Asn Tyr Gln Pro Val Asn Pro Pro Ile Val Ile Asp Leu 
305                 310                 315                 320 


Pro Thr Pro Arg Asn Ser 
                325     


<210>  8846
<211>  209
<212>  PRT
<213>  Homo Sapiens

<400>  8846

Met Ala Ala Ser Ala Gly Ala Gly Ala Val Ile Ala Ala Pro Asp Ser 
1               5                   10                  15      


Arg Arg Trp Leu Trp Ser Val Leu Ala Ala Ala Leu Gly Leu Leu Thr 
            20                  25                  30          


Ala Gly Val Ser Ala Leu Glu Val Tyr Thr Pro Lys Glu Ile Phe Val 
        35                  40                  45              


Ala Asn Gly Thr Gln Gly Lys Leu Thr Cys Lys Phe Lys Ser Thr Ser 
    50                  55                  60                  


Thr Thr Gly Gly Leu Thr Ser Val Ser Trp Ser Phe Gln Pro Glu Gly 
65                  70                  75                  80  


Ala Asp Thr Thr Val Ser Phe Phe His Tyr Ser Gln Gly Gln Val Tyr 
                85                  90                  95      


Leu Gly Asn Tyr Pro Pro Phe Lys Asp Arg Ile Ser Trp Ala Gly Asp 
            100                 105                 110         


Leu Asp Lys Lys Asp Ala Ser Ile Asn Ile Glu Asn Met Gln Phe Ile 
        115                 120                 125             


His Asn Gly Thr Tyr Ile Cys Asp Val Lys Asn Pro Pro Asp Ile Val 
    130                 135                 140                 


Val Gln Pro Gly His Ile Arg Leu Tyr Val Val Glu Lys Glu Asn Leu 
145                 150                 155                 160 


Pro Val Phe Pro Val Trp Val Val Val Gly Ile Val Thr Ala Val Val 
                165                 170                 175     


Leu Gly Leu Thr Leu Leu Ile Ser Met Ile Leu Ala Val Leu Tyr Arg 
            180                 185                 190         


Arg Lys Asn Ser Lys Arg Asp Tyr Thr Gly Ala Gln Ser Tyr Met His 
        195                 200                 205             


Ser 
    


<210>  8847
<211>  269
<212>  PRT
<213>  Homo Sapiens

<400>  8847

Met Ala Ala Ser Ala Gly Ala Gly Ala Val Ile Ala Ala Pro Asp Ser 
1               5                   10                  15      


Arg Arg Trp Leu Trp Ser Val Leu Ala Ala Ala Leu Gly Leu Leu Thr 
            20                  25                  30          


Ala Gly Val Ser Ala Leu Glu Val Tyr Thr Pro Lys Glu Ile Phe Val 
        35                  40                  45              


Ala Asn Gly Thr Gln Gly Lys Leu Thr Cys Lys Phe Lys Ser Thr Ser 
    50                  55                  60                  


Thr Thr Gly Gly Leu Thr Ser Val Ser Trp Ser Phe Gln Pro Glu Gly 
65                  70                  75                  80  


Ala Asp Thr Thr Val Ser Phe Phe His Tyr Ser Gln Gly Gln Val Tyr 
                85                  90                  95      


Leu Gly Asn Tyr Pro Pro Phe Lys Asp Arg Ile Ser Trp Ala Gly Asp 
            100                 105                 110         


Leu Asp Lys Lys Asp Ala Ser Ile Asn Ile Glu Asn Met Gln Phe Ile 
        115                 120                 125             


His Asn Gly Thr Tyr Ile Cys Asp Val Lys Asn Pro Pro Asp Ile Val 
    130                 135                 140                 


Val Gln Pro Gly His Ile Arg Leu Tyr Val Val Glu Lys Glu Asn Leu 
145                 150                 155                 160 


Pro Val Phe Pro Val Trp Val Val Val Gly Ile Val Thr Ala Val Val 
                165                 170                 175     


Leu Gly Leu Thr Leu Leu Ile Ser Met Ile Leu Ala Val Leu Tyr Arg 
            180                 185                 190         


Arg Lys Asn Ser Lys Arg Asp Tyr Thr Gly Cys Ser Thr Ser Glu Ser 
        195                 200                 205             


Leu Ser Pro Val Lys Gln Ala Pro Arg Lys Ser Pro Ser Asp Thr Glu 
    210                 215                 220                 


Gly Leu Val Lys Ser Leu Pro Ser Gly Ser His Gln Gly Pro Val Ile 
225                 230                 235                 240 


Tyr Ala Gln Leu Asp His Ser Gly Gly His His Ser Asp Lys Ile Asn 
                245                 250                 255     


Lys Ser Glu Ser Val Val Tyr Ala Asp Ile Arg Lys Asn 
            260                 265                 


<210>  8848
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  8848

Met Ala Ala Ser Ala Gly Ala Gly Ala Val Ile Ala Ala Pro Asp Ser 
1               5                   10                  15      


Arg Arg Trp Leu Trp Ser Val Leu Ala Ala Ala Leu Gly Leu Leu Thr 
            20                  25                  30          


Ala Gly Val Ser Ala Leu Glu Val Tyr Thr Pro Lys Glu Ile Phe Val 
        35                  40                  45              


Ala Asn Gly Thr Gln Gly Lys Leu Thr Cys Lys Phe Lys Ser Thr Ser 
    50                  55                  60                  


Thr Thr Gly Gly Leu Thr Ser Val Ser Trp Ser Phe Gln Pro Glu Gly 
65                  70                  75                  80  


Ala Asp Thr Thr Val Ser Gly Pro Val Ile Tyr Ala Gln Leu Asp His 
                85                  90                  95      


Ser Gly Gly His His Ser Asp Lys Ile Asn Lys Ser Glu Ser Val Val 
            100                 105                 110         


Tyr Ala Asp Ile Arg Lys Asn 
        115                 


<210>  8849
<211>  95
<212>  PRT
<213>  Homo Sapiens

<400>  8849

Met Ala Ala Ser Ala Gly Ala Gly Ala Val Ile Ala Ala Pro Asp Ser 
1               5                   10                  15      


Arg Arg Trp Leu Trp Ser Val Leu Ala Ala Ala Leu Gly Leu Leu Thr 
            20                  25                  30          


Ala Gly Val Ser Ala Leu Glu Val Tyr Thr Pro Lys Glu Ile Phe Val 
        35                  40                  45              


Ala Asn Gly Thr Gln Gly Lys Leu Thr Cys Lys Phe Lys Ser Thr Ser 
    50                  55                  60                  


Thr Thr Gly Gly Leu Thr Ser Val Ser Trp Ser Phe Gln Pro Glu Gly 
65                  70                  75                  80  


Ala Asp Thr Thr Val Ser Arg Ile Cys Leu Cys Phe Gln Phe Gly 
                85                  90                  95  


<210>  8850
<211>  183
<212>  PRT
<213>  Homo Sapiens

<400>  8850

Pro Phe Ser Ser Val Thr Ala Gly Val Ser Ala Leu Glu Val Tyr Thr 
1               5                   10                  15      


Pro Lys Glu Ile Phe Val Ala Asn Gly Thr Gln Gly Lys Leu Thr Cys 
            20                  25                  30          


Lys Phe Lys Ser Thr Ser Thr Thr Gly Gly Leu Thr Ser Val Ser Trp 
        35                  40                  45              


Ser Phe Gln Pro Glu Gly Ala Asp Thr Thr Val Ser Phe Phe His Tyr 
    50                  55                  60                  


Ser Gln Gly Gln Val Tyr Leu Gly Asn Tyr Pro Pro Phe Lys Asp Arg 
65                  70                  75                  80  


Ile Ser Trp Ala Gly Asp Leu Asp Lys Lys Asp Ala Ser Ile Asn Ile 
                85                  90                  95      


Glu Asn Met Gln Phe Ile His Asn Gly Thr Tyr Ile Cys Asp Val Lys 
            100                 105                 110         


Asn Pro Pro Asp Ile Val Val Gln Pro Gly His Ile Arg Leu Tyr Val 
        115                 120                 125             


Val Glu Lys Glu Asn Leu Pro Val Phe Pro Val Trp Val Val Val Gly 
    130                 135                 140                 


Ile Val Thr Ala Val Val Leu Gly Leu Thr Leu Leu Ile Ser Met Ile 
145                 150                 155                 160 


Leu Ala Val Leu Tyr Arg Arg Lys Asn Ser Lys Arg Asp Tyr Thr Gly 
                165                 170                 175     


Ala Gln Ser Tyr Met His Ser 
            180             


<210>  8851
<211>  296
<212>  PRT
<213>  Homo Sapiens

<400>  8851

Met Gly Glu Leu Met Ala Phe Leu Leu Pro Leu Ile Ile Val Leu Met 
1               5                   10                  15      


Val Lys His Ser Asp Ser Arg Thr His Ser Leu Arg Tyr Phe Arg Leu 
            20                  25                  30          


Gly Val Ser Asp Pro Ile His Gly Val Pro Glu Phe Ile Ser Val Gly 
        35                  40                  45              


Tyr Val Asp Ser His Pro Ile Thr Thr Tyr Asp Ser Val Thr Arg Gln 
    50                  55                  60                  


Lys Glu Pro Arg Ala Pro Trp Met Ala Glu Asn Leu Ala Pro Asp His 
65                  70                  75                  80  


Trp Glu Arg Tyr Thr Gln Leu Leu Arg Gly Trp Gln Gln Met Phe Lys 
                85                  90                  95      


Val Glu Leu Lys Arg Leu Gln Arg His Tyr Asn His Ser Asp Asn Val 
            100                 105                 110         


Ala His Thr Ile Lys Gln Ala Trp Glu Ala Asn Gln His Glu Leu Leu 
        115                 120                 125             


Tyr Gln Lys Asn Trp Leu Glu Glu Glu Cys Ile Ala Trp Leu Lys Arg 
    130                 135                 140                 


Phe Leu Glu Tyr Gly Lys Asp Thr Leu Gln Arg Thr Glu Pro Pro Leu 
145                 150                 155                 160 


Val Arg Val Asn Arg Lys Glu Thr Phe Pro Gly Val Thr Ala Leu Phe 
                165                 170                 175     


Cys Lys Ala His Gly Phe Tyr Pro Pro Glu Ile Tyr Met Thr Trp Met 
            180                 185                 190         


Lys Asn Gly Glu Glu Ile Val Gln Glu Ile Asp Tyr Gly Asp Ile Leu 
        195                 200                 205             


Pro Ser Gly Asp Gly Thr Tyr Gln Ala Trp Ala Ser Ile Glu Leu Asp 
    210                 215                 220                 


Pro Gln Ser Ser Asn Leu Tyr Ser Cys His Val Glu His Cys Gly Val 
225                 230                 235                 240 


His Met Val Leu Gln Val Pro Gln Glu Ser Glu Thr Ile Pro Leu Val 
                245                 250                 255     


Met Lys Ala Val Ser Gly Ser Ile Val Leu Val Ile Val Leu Ala Gly 
            260                 265                 270         


Val Gly Val Leu Val Trp Arg Arg Arg Pro Arg Glu Gln Asn Gly Ala 
        275                 280                 285             


Ile Tyr Leu Pro Thr Pro Asp Arg 
    290                 295     


<210>  8852
<211>  341
<212>  PRT
<213>  Homo Sapiens

<400>  8852

Met Gly Glu Leu Met Ala Phe Leu Leu Pro Leu Ile Ile Val Leu Met 
1               5                   10                  15      


Val Lys His Ser Asp Ser Arg Thr His Ser Leu Arg Tyr Phe Arg Leu 
            20                  25                  30          


Gly Val Ser Asp Pro Ile His Gly Val Pro Glu Phe Ile Ser Val Gly 
        35                  40                  45              


Tyr Val Asp Ser His Pro Ile Thr Thr Tyr Asp Ser Val Thr Arg Gln 
    50                  55                  60                  


Lys Glu Pro Arg Ala Pro Trp Met Ala Glu Asn Leu Ala Pro Asp His 
65                  70                  75                  80  


Trp Glu Arg Tyr Thr Gln Leu Leu Arg Gly Trp Gln Gln Met Phe Lys 
                85                  90                  95      


Val Glu Leu Lys Arg Leu Gln Arg His Tyr Asn His Ser Gly Ser His 
            100                 105                 110         


Thr Tyr Gln Arg Met Ile Gly Cys Glu Leu Leu Glu Asp Gly Ser Thr 
        115                 120                 125             


Thr Gly Phe Leu Gln Tyr Ala Tyr Asp Gly Gln Asp Phe Leu Ile Phe 
    130                 135                 140                 


Asn Lys Asp Thr Leu Ser Trp Leu Ala Val Asp Asn Val Ala His Thr 
145                 150                 155                 160 


Ile Lys Gln Ala Trp Glu Ala Asn Gln His Glu Leu Leu Tyr Gln Lys 
                165                 170                 175     


Asn Trp Leu Glu Glu Glu Cys Ile Ala Trp Leu Lys Arg Phe Leu Glu 
            180                 185                 190         


Tyr Gly Lys Asp Thr Leu Gln Arg Thr Glu Pro Pro Leu Val Arg Val 
        195                 200                 205             


Asn Arg Lys Glu Thr Phe Pro Gly Val Thr Ala Leu Phe Cys Lys Ala 
    210                 215                 220                 


His Gly Phe Tyr Pro Pro Glu Ile Tyr Met Thr Trp Met Lys Asn Gly 
225                 230                 235                 240 


Glu Glu Ile Val Gln Glu Ile Asp Tyr Gly Asp Ile Leu Pro Ser Gly 
                245                 250                 255     


Asp Gly Thr Tyr Gln Ala Trp Ala Ser Ile Glu Leu Asp Pro Gln Ser 
            260                 265                 270         


Ser Asn Leu Tyr Ser Cys His Val Glu His Cys Gly Val His Met Val 
        275                 280                 285             


Leu Gln Val Pro Gln Glu Ser Glu Thr Ile Pro Leu Val Met Lys Ala 
    290                 295                 300                 


Val Ser Gly Ser Ile Val Leu Val Ile Val Leu Ala Gly Val Gly Val 
305                 310                 315                 320 


Leu Val Trp Arg Arg Arg Pro Arg Glu Gln Asn Gly Ala Ile Tyr Leu 
                325                 330                 335     


Pro Thr Pro Asp Arg 
            340     


<210>  8853
<211>  341
<212>  PRT
<213>  Homo Sapiens

<400>  8853

Met Gly Glu Leu Met Ala Phe Leu Leu Pro Leu Ile Ile Val Leu Met 
1               5                   10                  15      


Val Lys His Ser Asp Ser Arg Thr His Ser Leu Arg Tyr Phe Arg Leu 
            20                  25                  30          


Gly Val Ser Asp Pro Ile His Gly Val Pro Glu Phe Ile Ser Val Gly 
        35                  40                  45              


Tyr Val Asp Ser His Pro Ile Thr Thr Tyr Asp Ser Val Thr Arg Gln 
    50                  55                  60                  


Lys Glu Pro Arg Ala Pro Trp Met Ala Glu Asn Leu Ala Pro Asp His 
65                  70                  75                  80  


Trp Glu Arg Tyr Thr Gln Leu Leu Arg Gly Trp Gln Gln Met Phe Lys 
                85                  90                  95      


Val Glu Leu Lys Arg Leu Gln Arg His Tyr Asn His Ser Gly Ser His 
            100                 105                 110         


Thr Tyr Gln Arg Met Ile Gly Cys Glu Leu Leu Glu Asp Gly Ser Thr 
        115                 120                 125             


Thr Gly Phe Leu Gln Tyr Ala Tyr Asp Gly Gln Asp Phe Leu Ile Phe 
    130                 135                 140                 


Asn Lys Asp Thr Leu Ser Trp Leu Ala Val Asp Asn Val Ala His Thr 
145                 150                 155                 160 


Ile Lys Gln Ala Trp Glu Ala Asn Gln His Glu Leu Leu Tyr Gln Lys 
                165                 170                 175     


Asn Trp Leu Glu Glu Glu Cys Ile Ala Trp Leu Lys Arg Phe Leu Glu 
            180                 185                 190         


Tyr Gly Lys Asp Thr Leu Gln Arg Thr Glu Pro Pro Leu Val Arg Val 
        195                 200                 205             


Asn Arg Lys Glu Thr Phe Pro Gly Val Thr Ala Leu Phe Cys Lys Ala 
    210                 215                 220                 


His Gly Phe Tyr Pro Pro Glu Ile Tyr Met Thr Trp Met Lys Asn Gly 
225                 230                 235                 240 


Glu Glu Ile Val Gln Glu Ile Asp Tyr Gly Asp Ile Leu Pro Ser Gly 
                245                 250                 255     


Asp Gly Thr Tyr Gln Ala Trp Ala Ser Ile Glu Leu Asp Pro Gln Ser 
            260                 265                 270         


Ser Asn Leu Tyr Ser Cys His Val Glu His Cys Gly Val His Met Val 
        275                 280                 285             


Leu Gln Val Pro Gln Glu Ser Glu Thr Ile Pro Leu Val Met Lys Ala 
    290                 295                 300                 


Val Ser Gly Ser Ile Val Leu Val Ile Val Leu Ala Gly Val Gly Val 
305                 310                 315                 320 


Leu Val Trp Arg Arg Arg Pro Arg Glu Gln Asn Gly Ala Ile Tyr Leu 
                325                 330                 335     


Pro Thr Pro Asp Arg 
            340     


<210>  8854
<211>  214
<212>  PRT
<213>  Homo Sapiens

<400>  8854

Met Gly Glu Leu Met Ala Phe Leu Leu Pro Leu Ile Ile Val Leu Met 
1               5                   10                  15      


Val Lys His Ser Asp Ser Arg Thr His Ser Leu Arg Tyr Phe Arg Leu 
            20                  25                  30          


Gly Val Ser Asp Pro Ile His Gly Val Pro Glu Phe Ile Ser Val Gly 
        35                  40                  45              


Tyr Val Asp Ser His Pro Ile Thr Thr Tyr Asp Ser Val Thr Arg Gln 
    50                  55                  60                  


Lys Glu Pro Arg Ala Pro Trp Met Ala Glu Asn Leu Ala Pro Asp His 
65                  70                  75                  80  


Trp Glu Arg Tyr Thr Gln Leu Leu Arg Gly Trp Gln Gln Met Phe Lys 
                85                  90                  95      


Val Glu Leu Lys Arg Leu Gln Arg His Tyr Asn His Ser Gly Ser His 
            100                 105                 110         


Thr Tyr Gln Arg Met Ile Gly Cys Glu Leu Leu Glu Asp Gly Ser Thr 
        115                 120                 125             


Thr Gly Phe Leu Gln Tyr Ala Tyr Asp Gly Gln Asp Phe Leu Ile Phe 
    130                 135                 140                 


Asn Lys Asp Thr Leu Ser Trp Leu Ala Val Asp Asn Val Ala His Thr 
145                 150                 155                 160 


Ile Lys Gln Ala Trp Glu Ala Asn Gln His Glu Leu Leu Tyr Gln Lys 
                165                 170                 175     


Asn Trp Leu Glu Glu Glu Cys Ile Ala Trp Leu Lys Arg Phe Leu Glu 
            180                 185                 190         


Tyr Gly Lys Asp Thr Leu Gln Arg Thr Glu Gln Asn Gly Ala Ile Tyr 
        195                 200                 205             


Leu Pro Thr Pro Asp Arg 
    210                 


<210>  8855
<211>  249
<212>  PRT
<213>  Homo Sapiens

<400>  8855

Met Gly Glu Leu Met Ala Phe Leu Leu Pro Leu Ile Ile Val Leu Met 
1               5                   10                  15      


Val Lys His Ser Asp Ser Arg Thr His Ser Leu Arg Tyr Phe Arg Leu 
            20                  25                  30          


Gly Val Ser Asp Pro Ile His Gly Val Pro Glu Phe Ile Ser Val Gly 
        35                  40                  45              


Tyr Val Asp Ser His Pro Ile Thr Thr Tyr Asp Ser Val Thr Arg Gln 
    50                  55                  60                  


Lys Glu Pro Arg Ala Pro Trp Met Ala Glu Asn Leu Ala Pro Asp His 
65                  70                  75                  80  


Trp Glu Arg Tyr Thr Gln Leu Leu Arg Gly Trp Gln Gln Met Phe Lys 
                85                  90                  95      


Val Glu Leu Lys Arg Leu Gln Arg His Tyr Asn His Ser Gly Ser His 
            100                 105                 110         


Thr Tyr Gln Arg Met Ile Gly Cys Glu Leu Leu Glu Asp Gly Ser Thr 
        115                 120                 125             


Thr Gly Phe Leu Gln Tyr Ala Tyr Asp Gly Gln Asp Phe Leu Ile Phe 
    130                 135                 140                 


Asn Lys Asp Thr Leu Ser Trp Leu Ala Val Asp Asn Val Ala His Thr 
145                 150                 155                 160 


Ile Lys Gln Ala Trp Glu Ala Asn Gln His Glu Leu Leu Tyr Gln Lys 
                165                 170                 175     


Asn Trp Leu Glu Glu Glu Cys Ile Ala Trp Leu Lys Arg Phe Leu Glu 
            180                 185                 190         


Tyr Gly Lys Asp Thr Leu Gln Arg Thr Glu Ser Glu Thr Ile Pro Leu 
        195                 200                 205             


Val Met Lys Ala Val Ser Gly Ser Ile Val Leu Val Ile Val Leu Ala 
    210                 215                 220                 


Gly Val Gly Val Leu Val Trp Arg Arg Arg Pro Arg Glu Gln Asn Gly 
225                 230                 235                 240 


Ala Ile Tyr Leu Pro Thr Pro Asp Arg 
                245                 


<210>  8856
<211>  249
<212>  PRT
<213>  Homo Sapiens

<400>  8856

Met Gly Glu Leu Met Ala Phe Leu Leu Pro Leu Ile Ile Val Leu Met 
1               5                   10                  15      


Val Lys His Ser Asp Ser Arg Thr His Ser Leu Arg Tyr Phe Arg Leu 
            20                  25                  30          


Gly Val Ser Asp Pro Ile His Gly Val Pro Glu Phe Ile Ser Val Gly 
        35                  40                  45              


Tyr Val Asp Ser His Pro Ile Thr Thr Tyr Asp Ser Val Thr Arg Gln 
    50                  55                  60                  


Lys Glu Pro Arg Ala Pro Trp Met Ala Glu Asn Leu Ala Pro Asp His 
65                  70                  75                  80  


Trp Glu Arg Tyr Thr Gln Leu Leu Arg Gly Trp Gln Gln Met Phe Lys 
                85                  90                  95      


Val Glu Leu Lys Arg Leu Gln Arg His Tyr Asn His Ser Gly Ser His 
            100                 105                 110         


Thr Tyr Gln Arg Met Ile Gly Cys Glu Leu Leu Glu Asp Gly Ser Thr 
        115                 120                 125             


Thr Gly Phe Leu Gln Tyr Ala Tyr Asp Gly Gln Asp Phe Leu Ile Phe 
    130                 135                 140                 


Asn Lys Asp Thr Leu Ser Trp Leu Ala Val Asp Asn Val Ala His Thr 
145                 150                 155                 160 


Ile Lys Gln Ala Trp Glu Ala Asn Gln His Glu Leu Leu Tyr Gln Lys 
                165                 170                 175     


Asn Trp Leu Glu Glu Glu Cys Ile Ala Trp Leu Lys Arg Phe Leu Glu 
            180                 185                 190         


Tyr Gly Lys Asp Thr Leu Gln Arg Thr Glu Ser Glu Thr Ile Pro Leu 
        195                 200                 205             


Val Met Lys Ala Val Ser Gly Ser Ile Val Leu Val Ile Val Leu Ala 
    210                 215                 220                 


Gly Val Gly Val Leu Val Trp Arg Arg Arg Pro Arg Glu Gln Asn Gly 
225                 230                 235                 240 


Ala Ile Tyr Leu Pro Thr Pro Asp Arg 
                245                 


<210>  8857
<211>  103
<212>  PRT
<213>  Homo Sapiens

<400>  8857

Met Ala Leu Cys Ala Leu Thr Arg Ala Leu Arg Ser Leu Asn Leu Ala 
1               5                   10                  15      


Pro Pro Thr Val Ala Ala Pro Ala Pro Ser Leu Phe Pro Ala Ala Gln 
            20                  25                  30          


Met Met Asn Asn Gly Leu Leu Gln Gln Pro Ser Ala Leu Met Leu Leu 
        35                  40                  45              


Pro Cys Arg Pro Val Leu Thr Ser Val Ala Leu Asn Ala Asn Phe Val 
    50                  55                  60                  


Ser Trp Lys Ser Arg Thr Lys Tyr Thr Ile Thr Pro Val Lys Met Arg 
65                  70                  75                  80  


Lys Ser Gly Gly Arg Asp His Thr Gly Ala Gly Asn Val Arg Ser Asn 
                85                  90                  95      


Ser Arg Pro Ser Ile Gln Arg 
            100             


<210>  8858
<211>  96
<212>  PRT
<213>  Homo Sapiens

<400>  8858

Met Ala Leu Cys Ala Leu Thr Arg Ala Leu Arg Ser Leu Asn Leu Ala 
1               5                   10                  15      


Pro Pro Thr Val Ala Ala Pro Ala Pro Ser Leu Phe Pro Ala Ala Gln 
            20                  25                  30          


Met Met Asn Asn Gly Leu Leu Gln Gln Pro Ser Ala Leu Met Leu Leu 
        35                  40                  45              


Pro Cys Arg Pro Val Leu Thr Ser Val Ala Leu Asn Ala Asn Phe Val 
    50                  55                  60                  


Ser Trp Lys Ser Arg Thr Lys Tyr Thr Ile Thr Pro Val Lys Met Arg 
65                  70                  75                  80  


Lys Ser Gly Gly Arg Asp His Thr Gly Gly Asn Lys Asp Arg Gly Ile 
                85                  90                  95      


<210>  8859
<211>  225
<212>  PRT
<213>  Homo Sapiens

<400>  8859

Met Ala Leu Cys Ala Leu Thr Arg Ala Leu Arg Ser Leu Asn Leu Ala 
1               5                   10                  15      


Pro Pro Thr Val Ala Ala Pro Ala Pro Ser Leu Phe Pro Ala Ala Gln 
            20                  25                  30          


Met Met Asn Asn Gly Leu Leu Gln Gln Pro Ser Ala Leu Met Leu Leu 
        35                  40                  45              


Pro Cys Arg Pro Val Leu Thr Ser Val Ala Leu Asn Ala Asn Phe Val 
    50                  55                  60                  


Ser Trp Lys Ser Arg Thr Lys Tyr Thr Ile Thr Pro Val Lys Met Arg 
65                  70                  75                  80  


Lys Ser Gly Gly Arg Asp His Thr Gly Arg Ile Arg Val His Gly Ile 
                85                  90                  95      


Gly Gly Gly His Lys Gln Arg Tyr Arg Met Ile Asp Phe Leu Arg Phe 
            100                 105                 110         


Arg Pro Glu Glu Thr Lys Ser Gly Pro Phe Glu Glu Lys Val Ile Gln 
        115                 120                 125             


Val Arg Tyr Asp Pro Cys Arg Ser Ala Asp Ile Ala Leu Val Ala Gly 
    130                 135                 140                 


Gly Ser Arg Lys Arg Trp Ile Ile Ala Thr Glu Asn Met Gln Ala Gly 
145                 150                 155                 160 


Asp Thr Ile Leu Asn Ser Asn His Ile Gly Arg Met Ala Val Ala Ala 
                165                 170                 175     


Arg Glu Gly Asp Ala His Pro Leu Gly Ala Leu Pro Val Gly Thr Leu 
            180                 185                 190         


Ile Asn Asn Val Glu Ser Glu Pro Gly Arg Gly Ala Gln Tyr Ile Arg 
        195                 200                 205             


Ala Ala Gly Ala Gly Asn Val Arg Ser Asn Ser Arg Pro Ser Ile Gln 
    210                 215                 220                 


Arg 
225 


<210>  8860
<211>  305
<212>  PRT
<213>  Homo Sapiens

<400>  8860

Met Ala Leu Cys Ala Leu Thr Arg Ala Leu Arg Ser Leu Asn Leu Ala 
1               5                   10                  15      


Pro Pro Thr Val Ala Ala Pro Ala Pro Ser Leu Phe Pro Ala Ala Gln 
            20                  25                  30          


Met Met Asn Asn Gly Leu Leu Gln Gln Pro Ser Ala Leu Met Leu Leu 
        35                  40                  45              


Pro Cys Arg Pro Val Leu Thr Ser Val Ala Leu Asn Ala Asn Phe Val 
    50                  55                  60                  


Ser Trp Lys Ser Arg Thr Lys Tyr Thr Ile Thr Pro Val Lys Met Arg 
65                  70                  75                  80  


Lys Ser Gly Gly Arg Asp His Thr Gly Arg Ile Arg Val His Gly Ile 
                85                  90                  95      


Gly Gly Gly His Lys Gln Arg Tyr Arg Met Ile Asp Phe Leu Arg Phe 
            100                 105                 110         


Arg Pro Glu Glu Thr Lys Ser Gly Pro Phe Glu Glu Lys Val Ile Gln 
        115                 120                 125             


Val Arg Tyr Asp Pro Cys Arg Ser Ala Asp Ile Ala Leu Val Ala Gly 
    130                 135                 140                 


Gly Ser Arg Lys Arg Trp Ile Ile Ala Thr Glu Asn Met Gln Ala Gly 
145                 150                 155                 160 


Asp Thr Ile Leu Asn Ser Asn His Ile Gly Arg Met Ala Val Ala Ala 
                165                 170                 175     


Arg Glu Gly Asp Ala His Pro Leu Gly Ala Leu Pro Val Gly Thr Leu 
            180                 185                 190         


Ile Asn Asn Val Glu Ser Glu Pro Gly Arg Gly Ala Gln Tyr Ile Arg 
        195                 200                 205             


Ala Ala Gly Thr Cys Gly Val Leu Leu Arg Lys Val Asn Gly Thr Ala 
    210                 215                 220                 


Ile Ile Gln Leu Pro Ser Lys Arg Gln Met Gln Val Leu Glu Thr Cys 
225                 230                 235                 240 


Val Ala Thr Val Gly Arg Val Ser Asn Val Asp His Asn Lys Arg Val 
                245                 250                 255     


Ile Gly Lys Ala Gly Arg Asn Arg Trp Leu Gly Lys Arg Pro Asn Ser 
            260                 265                 270         


Gly Arg Trp His Arg Lys Gly Gly Trp Ala Gly Arg Lys Ile Arg Pro 
        275                 280                 285             


Leu Pro Pro Met Lys Ser Tyr Val Lys Leu Pro Ser Ala Ser Ala Gln 
    290                 295                 300                 


Ser 
305 


<210>  8861
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  8861

Met Ala Leu Cys Ala Leu Thr Arg Ala Leu Arg Ser Leu Asn Leu Ala 
1               5                   10                  15      


Pro Pro Thr Val Ala Ala Pro Ala Pro Ser Leu Phe Pro Ala Ala Gln 
            20                  25                  30          


Val Ile His Leu Thr Arg Glu Glu Gly Cys Phe His Ser Gly Cys Arg 
        35                  40                  45              


Arg Trp Gly Leu Arg Ala Cys Glu Ala Gly Val Ala Ser Leu Val Arg 
    50                  55                  60                  


Ser His Ala Asp Asp Glu Gln Trp Pro Pro Pro Thr Ala Leu Cys Leu 
65                  70                  75                  80  


Asp Val Ala Pro Leu Pro Pro Ser Ser Tyr Phe Cys Gly Pro 
                85                  90                  


<210>  8862
<211>  49
<212>  PRT
<213>  Homo Sapiens

<400>  8862

Met Ala Ala Ser Ser Leu Thr Val Thr Leu Gly Arg Leu Ala Ser Ala 
1               5                   10                  15      


Cys Ser His Ser Ile Leu Arg Pro Ser Gly Pro Gly Ala Ala Ser Leu 
            20                  25                  30          


Trp Ser Ala Ser Arg Arg Phe Asn Ser Gln Ser Thr Ser Tyr Leu Pro 
        35                  40                  45              


Gly 
    


<210>  8863
<211>  49
<212>  PRT
<213>  Homo Sapiens

<400>  8863

Met Ala Ala Ser Ser Leu Thr Val Thr Leu Gly Arg Leu Ala Ser Ala 
1               5                   10                  15      


Cys Ser His Ser Ile Leu Arg Pro Ser Gly Pro Gly Ala Ala Ser Leu 
            20                  25                  30          


Trp Ser Ala Ser Arg Arg Phe Asn Ser Gln Ser Thr Ser Tyr Leu Pro 
        35                  40                  45              


Gly 
    


<210>  8864
<211>  150
<212>  PRT
<213>  Homo Sapiens

<400>  8864

Met Ala Ala Ser Ser Leu Thr Val Thr Leu Gly Arg Leu Ala Ser Ala 
1               5                   10                  15      


Cys Ser His Ser Ile Leu Arg Pro Ser Gly Pro Gly Ala Ala Ser Leu 
            20                  25                  30          


Trp Ser Ala Ser Arg Arg Phe Asn Ser Gln Ser Thr Ser Tyr Leu Pro 
        35                  40                  45              


Gly Tyr Val Pro Lys Thr Ser Leu Ser Ser Pro Pro Trp Pro Glu Val 
    50                  55                  60                  


Val Leu Pro Asp Pro Val Glu Glu Thr Arg His His Ala Glu Val Val 
65                  70                  75                  80  


Lys Lys Val Asn Glu Met Ile Val Thr Gly Gln Tyr Gly Arg Leu Phe 
                85                  90                  95      


Ala Val Val His Phe Ala Ser Arg Gln Trp Lys Val Thr Ser Glu Asp 
            100                 105                 110         


Leu Ile Leu Ile Gly Asn Glu Leu Asp Leu Ala Cys Gly Glu Arg Ile 
        115                 120                 125             


Arg Leu Glu Lys Val Leu Leu Val Gly Ala Asp Asn Phe Thr Leu Leu 
    130                 135                 140                 


Gly Lys Pro Leu Leu Gly 
145                 150 


<210>  8865
<211>  205
<212>  PRT
<213>  Homo Sapiens

<400>  8865

Met Ala Ala Ser Ser Leu Thr Val Thr Leu Gly Arg Leu Ala Ser Ala 
1               5                   10                  15      


Cys Ser His Ser Ile Leu Arg Pro Ser Gly Pro Gly Ala Ala Ser Leu 
            20                  25                  30          


Trp Ser Ala Ser Arg Arg Phe Asn Ser Gln Ser Thr Ser Tyr Leu Pro 
        35                  40                  45              


Gly Tyr Val Pro Lys Thr Ser Leu Ser Ser Pro Pro Trp Pro Glu Val 
    50                  55                  60                  


Val Leu Pro Asp Pro Val Glu Glu Thr Arg His His Ala Glu Val Val 
65                  70                  75                  80  


Lys Lys Val Asn Glu Met Ile Val Thr Gly Gln Tyr Gly Arg Leu Phe 
                85                  90                  95      


Ala Val Val His Phe Ala Ser Arg Gln Trp Lys Val Thr Ser Glu Asp 
            100                 105                 110         


Leu Ile Leu Ile Gly Asn Glu Leu Asp Leu Ala Cys Gly Glu Arg Ile 
        115                 120                 125             


Arg Leu Glu Lys Val Leu Leu Val Gly Ala Asp Asn Phe Thr Leu Leu 
    130                 135                 140                 


Gly Lys Pro Leu Leu Gly Lys Asp Leu Val Arg Val Glu Ala Thr Val 
145                 150                 155                 160 


Ile Glu Lys Thr Glu Ser Trp Pro Arg Ile Ile Met Arg Phe Arg Lys 
                165                 170                 175     


Arg Lys Asn Phe Lys Lys Lys Arg Ile Val Thr Thr Pro Gln Thr Val 
            180                 185                 190         


Leu Arg Ile Asn Ser Ile Glu Ile Ala Pro Cys Leu Leu 
        195                 200                 205 


<210>  8866
<211>  36
<212>  PRT
<213>  Homo Sapiens

<400>  8866

Met Ala Ala Ser Ser Leu Thr Val Thr Leu Gly Arg Leu Ala Ser Ala 
1               5                   10                  15      


Cys Ser His Ser Ile Leu Arg Pro Ser Gly Pro Gly Ala Asp Met Phe 
            20                  25                  30          


Leu Lys His Pro 
        35      


<210>  8867
<211>  120
<212>  PRT
<213>  Homo Sapiens

<400>  8867

Met Ile Val Thr Gly Gln Tyr Gly Arg Leu Phe Ala Val Val His Phe 
1               5                   10                  15      


Ala Ser Arg Gln Trp Lys Val Thr Ser Glu Asp Leu Ile Leu Ile Gly 
            20                  25                  30          


Asn Glu Leu Asp Leu Ala Cys Gly Glu Arg Ile Arg Leu Glu Lys Val 
        35                  40                  45              


Leu Leu Val Gly Ala Asp Asn Phe Thr Leu Leu Gly Lys Pro Leu Leu 
    50                  55                  60                  


Gly Lys Asp Leu Val Arg Val Glu Ala Thr Val Ile Glu Lys Thr Glu 
65                  70                  75                  80  


Ser Trp Pro Arg Ile Ile Met Arg Phe Arg Lys Arg Lys Asn Phe Lys 
                85                  90                  95      


Lys Lys Arg Ile Val Thr Thr Pro Gln Thr Val Leu Arg Ile Asn Ser 
            100                 105                 110         


Ile Glu Ile Ala Pro Cys Leu Leu 
        115                 120 


<210>  8868
<211>  195
<212>  PRT
<213>  Homo Sapiens

<400>  8868

Met Ile Val Thr Gly Gln Tyr Gly Arg Leu Phe Ala Val Val His Phe 
1               5                   10                  15      


Ala Ser Arg Gln Trp Lys Val Thr Ser Glu Asp Leu Ile Leu Ile Gly 
            20                  25                  30          


Asn Glu Leu Asp Leu Ala Cys Gly Glu Arg Ile Arg Leu Glu Lys Val 
        35                  40                  45              


Leu Leu Val Gly Ala Asp Asn Phe Thr Leu Leu Gly Lys Pro Leu Leu 
    50                  55                  60                  


Gly Lys Asp Leu Val Arg Val Glu Ala Thr Val Ile Glu Lys Thr Glu 
65                  70                  75                  80  


Ser Trp Pro Arg Ile Ile Met Arg Phe Arg Lys Arg Lys Asn Phe Lys 
                85                  90                  95      


Lys Lys Arg Ser Lys Leu Glu Lys Val Pro Leu Gly Pro Val Ala Arg 
            100                 105                 110         


Cys Trp Leu Pro Arg Arg Met Arg Thr Glu Gly Val Gly His Val Gly 
        115                 120                 125             


Leu Gly Thr Gly Ser Pro Gly Arg Ser Gln Pro Gly Cys His Cys Pro 
    130                 135                 140                 


Leu Ala Thr Leu Ile Leu Glu Gly Ala Pro Arg Gly Ser Ser Leu Ala 
145                 150                 155                 160 


Pro Leu Leu Leu His Ala Pro Arg Val Thr Pro Pro Arg Ser Pro Ser 
                165                 170                 175     


Pro Pro Arg Ser Ala Arg Asp Pro Thr Ser Leu Pro Phe Ser Ser Thr 
            180                 185                 190         


Leu Arg Ala 
        195 


<210>  8869
<211>  38
<212>  PRT
<213>  Homo Sapiens

<400>  8869

Glu Met Glu Ser Glu Leu Thr Ala Cys Val Asp Val Ala Gly Ala Leu 
1               5                   10                  15      


Trp Ile His Asn Leu Arg Ser Arg Gly Lys Leu Ala Leu Gly Lys Ser 
            20                  25                  30          


Thr Thr Val Glu Asp Lys 
        35              


<210>  8870
<211>  212
<212>  PRT
<213>  Homo Sapiens

<400>  8870

Met Ala Ala Ala Val Leu Gly Gln Leu Gly Ala Leu Trp Ile His Asn 
1               5                   10                  15      


Leu Arg Ser Arg Gly Lys Leu Ala Leu Gly Leu Leu Ser Phe His Ser 
            20                  25                  30          


Val Leu Pro Gln Ser Tyr Ile His Thr Ser Ala Ser Leu Asp Ile Ser 
        35                  40                  45              


Arg Lys Trp Glu Lys Lys Asn Lys Ile Val Tyr Pro Pro Gln Leu Pro 
    50                  55                  60                  


Gly Glu Pro Arg Arg Pro Ala Glu Ile Tyr His Cys Arg Arg Gln Ile 
65                  70                  75                  80  


Lys Tyr Ser Lys Asp Lys Met Trp Tyr Leu Ala Lys Leu Ile Arg Gly 
                85                  90                  95      


Met Ser Ile Asp Gln Ala Leu Ala Gln Leu Glu Phe Asn Asp Lys Lys 
            100                 105                 110         


Gly Ala Lys Ile Ile Lys Glu Val Leu Leu Glu Ala Gln Asp Met Ala 
        115                 120                 125             


Val Arg Asp His Asn Val Glu Phe Arg Ser Asn Leu Tyr Ile Ala Glu 
    130                 135                 140                 


Ser Thr Ser Gly Arg Gly Gln Cys Leu Lys Arg Ile Arg Tyr His Gly 
145                 150                 155                 160 


Arg Gly Arg Phe Gly Ile Met Glu Lys Val Tyr Cys His Tyr Phe Val 
                165                 170                 175     


Lys Leu Val Glu Gly Pro Pro Pro Pro Pro Glu Pro Pro Lys Thr Ala 
            180                 185                 190         


Val Ala His Ala Lys Glu Tyr Ile Gln Gln Leu Arg Ser Arg Thr Ile 
        195                 200                 205             


Val His Thr Leu 
    210         


<210>  8871
<211>  206
<212>  PRT
<213>  Homo Sapiens

<400>  8871

Met Ala Ala Ala Val Leu Gly Gln Leu Gly Ala Leu Trp Ile His Asn 
1               5                   10                  15      


Leu Arg Ser Arg Gly Lys Leu Ala Leu Gly Val Leu Pro Gln Ser Tyr 
            20                  25                  30          


Ile His Thr Ser Ala Ser Leu Asp Ile Ser Arg Lys Trp Glu Lys Lys 
        35                  40                  45              


Asn Lys Ile Val Tyr Pro Pro Gln Leu Pro Gly Glu Pro Arg Arg Pro 
    50                  55                  60                  


Ala Glu Ile Tyr His Cys Arg Arg Gln Ile Lys Tyr Ser Lys Asp Lys 
65                  70                  75                  80  


Met Trp Tyr Leu Ala Lys Leu Ile Arg Gly Met Ser Ile Asp Gln Ala 
                85                  90                  95      


Leu Ala Gln Leu Glu Phe Asn Asp Lys Lys Gly Ala Lys Ile Ile Lys 
            100                 105                 110         


Glu Val Leu Leu Glu Ala Gln Asp Met Ala Val Arg Asp His Asn Val 
        115                 120                 125             


Glu Phe Arg Ser Asn Leu Tyr Ile Ala Glu Ser Thr Ser Gly Arg Gly 
    130                 135                 140                 


Gln Cys Leu Lys Arg Ile Arg Tyr His Gly Arg Gly Arg Phe Gly Ile 
145                 150                 155                 160 


Met Glu Lys Val Tyr Cys His Tyr Phe Val Lys Leu Val Glu Gly Pro 
                165                 170                 175     


Pro Pro Pro Pro Glu Pro Pro Lys Thr Ala Val Ala His Ala Lys Glu 
            180                 185                 190         


Tyr Ile Gln Gln Leu Arg Ser Arg Thr Ile Val His Thr Leu 
        195                 200                 205     


<210>  8872
<211>  232
<212>  PRT
<213>  Homo Sapiens

<400>  8872

Met Ala Ala Ala Val Leu Gly Gln Leu Gly Lys Asp Phe Leu Val Val 
1               5                   10                  15      


Lys Arg Gln Lys Gly Val Glu Met Glu Ser Glu Leu Thr Ala Cys Val 
            20                  25                  30          


Asp Val Ala Gly Ala Leu Trp Ile His Asn Leu Arg Ser Arg Gly Lys 
        35                  40                  45              


Leu Ala Leu Gly Val Leu Pro Gln Ser Tyr Ile His Thr Ser Ala Ser 
    50                  55                  60                  


Leu Asp Ile Ser Arg Lys Trp Glu Lys Lys Asn Lys Ile Val Tyr Pro 
65                  70                  75                  80  


Pro Gln Leu Pro Gly Glu Pro Arg Arg Pro Ala Glu Ile Tyr His Cys 
                85                  90                  95      


Arg Arg Gln Ile Lys Tyr Ser Lys Asp Lys Met Trp Tyr Leu Ala Lys 
            100                 105                 110         


Leu Ile Arg Gly Met Ser Ile Asp Gln Ala Leu Ala Gln Leu Glu Phe 
        115                 120                 125             


Asn Asp Lys Lys Gly Ala Lys Ile Ile Lys Glu Val Leu Leu Glu Ala 
    130                 135                 140                 


Gln Asp Met Ala Val Arg Asp His Asn Val Glu Phe Arg Ser Asn Leu 
145                 150                 155                 160 


Tyr Ile Ala Glu Ser Thr Ser Gly Arg Gly Gln Cys Leu Lys Arg Ile 
                165                 170                 175     


Arg Tyr His Gly Arg Gly Arg Phe Gly Ile Met Glu Lys Val Tyr Cys 
            180                 185                 190         


His Tyr Phe Val Lys Leu Val Glu Gly Pro Pro Pro Pro Pro Glu Pro 
        195                 200                 205             


Pro Lys Thr Ala Val Ala His Ala Lys Glu Tyr Ile Gln Gln Leu Arg 
    210                 215                 220                 


Ser Arg Thr Ile Val His Thr Leu 
225                 230         


<210>  8873
<211>  126
<212>  PRT
<213>  Homo Sapiens

<400>  8873

Met Trp Tyr Leu Ala Lys Leu Ile Arg Gly Met Ser Ile Asp Gln Ala 
1               5                   10                  15      


Leu Ala Gln Leu Glu Phe Asn Asp Lys Lys Gly Ala Lys Ile Ile Lys 
            20                  25                  30          


Glu Val Leu Leu Glu Ala Gln Asp Met Ala Val Arg Asp His Asn Val 
        35                  40                  45              


Glu Phe Arg Ser Asn Leu Tyr Ile Ala Glu Ser Thr Ser Gly Arg Gly 
    50                  55                  60                  


Gln Cys Leu Lys Arg Ile Arg Tyr His Gly Arg Gly Arg Phe Gly Ile 
65                  70                  75                  80  


Met Glu Lys Val Tyr Cys His Tyr Phe Val Lys Leu Val Glu Gly Pro 
                85                  90                  95      


Pro Pro Pro Pro Glu Pro Pro Lys Thr Ala Val Ala His Ala Lys Glu 
            100                 105                 110         


Tyr Ile Gln Gln Leu Arg Ser Arg Thr Ile Val His Thr Leu 
        115                 120                 125     


<210>  8874
<211>  68
<212>  PRT
<213>  Homo Sapiens

<400>  8874

Met Arg Leu Ser Ala Leu Leu Ala Leu Ala Ser Lys Val Thr Leu Pro 
1               5                   10                  15      


Pro His Tyr Arg Tyr Gly Met Ser Pro Pro Gly Ser Val Ala Asp Lys 
            20                  25                  30          


Arg Lys Asn Pro Pro Trp Ile Arg Arg Arg Pro Val Val Val Glu Pro 
        35                  40                  45              


Ile Ser Asp Glu Asp Trp Tyr Leu Phe Cys Gly Asp Thr Val Glu Ile 
    50                  55                  60                  


Leu Glu Gly Lys 
65              


<210>  8875
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  8875

Met Arg Leu Ser Ala Leu Leu Ala Leu Ala Ser Lys Val Thr Leu Pro 
1               5                   10                  15      


Pro His Tyr Arg Tyr Gly Met Ser Pro Pro Gly Ser Val Ala Asp Lys 
            20                  25                  30          


Arg Lys Asn Pro Pro Trp Ile Arg Arg Arg Pro Val Val Val Glu Pro 
        35                  40                  45              


Ile Ser Asp Glu Asp Trp Tyr Leu Phe Cys Gly Asp Thr Val Glu Ile 
    50                  55                  60                  


Leu Glu Gly Lys Asp Ala Gly Lys Gln Gly Lys Val Val Gln Val Ile 
65                  70                  75                  80  


Arg Gln Arg Asn Trp Val Val Val Gly Gly Leu Asn Thr His Tyr Arg 
                85                  90                  95      


Tyr Ile Gly 
            


<210>  8876
<211>  173
<212>  PRT
<213>  Homo Sapiens

<400>  8876

Met Arg Leu Ser Ala Leu Leu Ala Leu Ala Ser Lys Val Thr Leu Pro 
1               5                   10                  15      


Pro His Tyr Arg Tyr Gly Met Ser Pro Pro Gly Ser Val Ala Asp Lys 
            20                  25                  30          


Arg Lys Asn Pro Pro Trp Ile Arg Arg Arg Pro Val Val Val Glu Pro 
        35                  40                  45              


Ile Ser Asp Glu Asp Trp Tyr Leu Phe Cys Gly Asp Thr Val Glu Ile 
    50                  55                  60                  


Leu Glu Gly Lys Asp Ala Gly Lys Gln Gly Lys Val Val Gln Val Ile 
65                  70                  75                  80  


Arg Gln Arg Asn Trp Val Val Val Gly Gly Leu Asn Thr His Tyr Arg 
                85                  90                  95      


Tyr Ile Gly Lys Thr Met Asp Tyr Arg Gly Thr Met Ile Pro Ser Glu 
            100                 105                 110         


Ala Pro Leu Leu His Arg Gln Val Lys Leu Val Asp Pro Met Asp Arg 
        115                 120                 125             


Lys Pro Thr Glu Ile Glu Trp Arg Phe Thr Glu Ala Gly Glu Arg Val 
    130                 135                 140                 


Arg Val Ser Thr Arg Ser Gly Arg Ile Ile Pro Lys Pro Glu Phe Pro 
145                 150                 155                 160 


Arg Ala Asp Gly Ile Val Pro Glu Thr Trp Ile Asp Gly 
                165                 170             


<210>  8877
<211>  216
<212>  PRT
<213>  Homo Sapiens

<400>  8877

Met Arg Leu Ser Ala Leu Leu Ala Leu Ala Ser Lys Val Thr Leu Pro 
1               5                   10                  15      


Pro His Tyr Arg Tyr Gly Met Ser Pro Pro Gly Ser Val Ala Asp Lys 
            20                  25                  30          


Arg Lys Asn Pro Pro Trp Ile Arg Arg Arg Pro Val Val Val Glu Pro 
        35                  40                  45              


Ile Ser Asp Glu Asp Trp Tyr Leu Phe Cys Gly Asp Thr Val Glu Ile 
    50                  55                  60                  


Leu Glu Gly Lys Asp Ala Gly Lys Gln Gly Lys Val Val Gln Val Ile 
65                  70                  75                  80  


Arg Gln Arg Asn Trp Val Val Val Gly Gly Leu Asn Thr His Tyr Arg 
                85                  90                  95      


Tyr Ile Gly Lys Thr Met Asp Tyr Arg Gly Thr Met Ile Pro Ser Glu 
            100                 105                 110         


Ala Pro Leu Leu His Arg Gln Val Lys Leu Val Asp Pro Met Asp Arg 
        115                 120                 125             


Lys Pro Thr Glu Ile Glu Trp Arg Phe Thr Glu Ala Gly Glu Arg Val 
    130                 135                 140                 


Arg Val Ser Thr Arg Ser Gly Arg Ile Ile Pro Lys Pro Glu Phe Pro 
145                 150                 155                 160 


Arg Ala Asp Gly Ile Val Pro Glu Thr Trp Ile Asp Gly Pro Lys Asp 
                165                 170                 175     


Thr Ser Val Glu Asp Ala Leu Glu Arg Thr Tyr Val Pro Cys Leu Lys 
            180                 185                 190         


Thr Leu Gln Glu Glu Val Met Glu Ala Met Gly Ile Lys Glu Thr Arg 
        195                 200                 205             


Lys Tyr Lys Lys Val Tyr Trp Tyr 
    210                 215     


<210>  8878
<211>  216
<212>  PRT
<213>  Homo Sapiens

<400>  8878

Met Arg Leu Ser Ala Leu Leu Ala Leu Ala Ser Lys Val Thr Leu Pro 
1               5                   10                  15      


Pro His Tyr Arg Tyr Gly Met Ser Pro Pro Gly Ser Val Ala Asp Lys 
            20                  25                  30          


Arg Lys Asn Pro Pro Trp Ile Arg Arg Arg Pro Val Val Val Glu Pro 
        35                  40                  45              


Ile Ser Asp Glu Asp Trp Tyr Leu Phe Cys Gly Asp Thr Val Glu Ile 
    50                  55                  60                  


Leu Glu Gly Lys Asp Ala Gly Lys Gln Gly Lys Val Val Gln Val Ile 
65                  70                  75                  80  


Arg Gln Arg Asn Trp Val Val Val Gly Gly Leu Asn Thr His Tyr Arg 
                85                  90                  95      


Tyr Ile Gly Lys Thr Met Asp Tyr Arg Gly Thr Met Ile Pro Ser Glu 
            100                 105                 110         


Ala Pro Leu Leu His Arg Gln Val Lys Leu Val Asp Pro Met Asp Arg 
        115                 120                 125             


Lys Pro Thr Glu Ile Glu Trp Arg Phe Thr Glu Ala Gly Glu Arg Val 
    130                 135                 140                 


Arg Val Ser Thr Arg Ser Gly Arg Ile Ile Pro Lys Pro Glu Phe Pro 
145                 150                 155                 160 


Arg Ala Asp Gly Ile Val Pro Glu Thr Trp Ile Asp Gly Pro Lys Asp 
                165                 170                 175     


Thr Ser Val Glu Asp Ala Leu Glu Arg Thr Tyr Val Pro Cys Leu Lys 
            180                 185                 190         


Thr Leu Gln Glu Glu Val Met Glu Ala Met Gly Ile Lys Glu Thr Arg 
        195                 200                 205             


Lys Tyr Lys Lys Val Tyr Trp Tyr 
    210                 215     


<210>  8879
<211>  148
<212>  PRT
<213>  Homo Sapiens

<400>  8879

Met Ala Ser Val Val Leu Ala Leu Arg Thr Arg Thr Ala Val Thr Ser 
1               5                   10                  15      


Leu Leu Ser Pro Thr Pro Ala Thr Ala Leu Ala Val Arg Tyr Ala Ser 
            20                  25                  30          


Lys Lys Ser Gly Gly Ser Ser Lys Asn Leu Gly Gly Lys Ser Ser Gly 
        35                  40                  45              


Arg Arg Gln Gly Ile Lys Lys Met Glu Gly His Tyr Val His Ala Gly 
    50                  55                  60                  


Asn Ile Ile Ala Thr Gln Arg His Phe Arg Trp His Pro Gly Ala His 
65                  70                  75                  80  


Val Gly Val Gly Lys Asn Lys Cys Leu Tyr Ala Leu Glu Glu Gly Ile 
                85                  90                  95      


Val Arg Tyr Thr Lys Glu Val Tyr Val Pro His Pro Arg Asn Thr Glu 
            100                 105                 110         


Ala Val Asp Leu Ile Thr Arg Leu Pro Lys Gly Ala Val Leu Tyr Lys 
        115                 120                 125             


Thr Phe Val His Val Val Pro Ala Lys Pro Glu Gly Thr Phe Lys Leu 
    130                 135                 140                 


Val Ala Met Leu 
145             


<210>  8880
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  8880

Met Ala Ser Val Val Leu Ala Leu Arg Thr Arg Thr Ala Val Thr Ser 
1               5                   10                  15      


Leu Leu Ser Pro Thr Pro Ala Thr Ala Leu Ala Val Arg Tyr Ala Ser 
            20                  25                  30          


Lys Lys Ser Gly Gly Ser Ser Lys Asn Leu Gly Gly Lys Ser Ser Gly 
        35                  40                  45              


Arg Arg Gln Gly Ile Lys Lys Met Glu Gly His Tyr Val His Ala Gly 
    50                  55                  60                  


Asn Ile Ile Ala Thr Gln Arg His Phe Arg Trp His Pro Gly Ala His 
65                  70                  75                  80  


Val Ser Cys Ser Val Ala Ala Pro Leu Phe Pro Phe Leu Gly 
                85                  90                  


<210>  8881
<211>  84
<212>  PRT
<213>  Homo Sapiens

<400>  8881

Met Ala Ser Val Val Leu Ala Leu Arg Thr Arg Thr Ala Val Thr Ser 
1               5                   10                  15      


Leu Leu Ser Pro Thr Pro Ala Thr Ala Leu Ala Val Arg Tyr Ala Ser 
            20                  25                  30          


Lys Lys Ser Gly Gly Ser Ser Lys Asn Leu Gly Gly Lys Ser Ser Gly 
        35                  40                  45              


Arg Arg Gln Gly Ile Lys Lys Met Glu Gly His Tyr Val His Ala Gly 
    50                  55                  60                  


Asn Ile Ile Ala Thr Gln Arg His Phe Arg Trp His Pro Gly Ala His 
65                  70                  75                  80  


Trp Arg Trp Lys 
                


<210>  8882
<211>  93
<212>  PRT
<213>  Homo Sapiens

<400>  8882

Met Glu Gly His Tyr Val His Ala Gly Asn Ile Ile Ala Thr Gln Arg 
1               5                   10                  15      


His Phe Arg Trp His Pro Gly Ala His Val Gly Val Gly Lys Asn Lys 
            20                  25                  30          


Cys Leu Tyr Ala Leu Glu Glu Gly Ile Val Arg Tyr Thr Lys Glu Val 
        35                  40                  45              


Tyr Val Pro His Pro Arg Asn Thr Glu Ala Val Asp Leu Ile Thr Arg 
    50                  55                  60                  


Leu Pro Lys Gly Ala Val Leu Tyr Lys Thr Phe Val His Val Val Pro 
65                  70                  75                  80  


Ala Lys Pro Glu Gly Thr Phe Lys Leu Val Ala Met Leu 
                85                  90              


<210>  8883
<211>  93
<212>  PRT
<213>  Homo Sapiens

<400>  8883

Met Glu Gly His Tyr Val His Ala Gly Asn Ile Ile Ala Thr Gln Arg 
1               5                   10                  15      


His Phe Arg Trp His Pro Gly Ala His Val Gly Val Gly Lys Asn Lys 
            20                  25                  30          


Cys Leu Tyr Ala Leu Glu Glu Gly Ile Val Arg Tyr Thr Lys Glu Val 
        35                  40                  45              


Tyr Val Pro His Pro Arg Asn Thr Glu Ala Val Asp Leu Ile Thr Arg 
    50                  55                  60                  


Leu Pro Lys Gly Ala Val Leu Tyr Lys Thr Phe Val His Val Val Pro 
65                  70                  75                  80  


Ala Lys Pro Glu Gly Thr Phe Lys Leu Val Ala Met Leu 
                85                  90              


<210>  8884
<211>  136
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8884

Xaa Ser Pro Thr Pro Ala Thr Ala Leu Ala Val Arg Tyr Ala Ser Lys 
1               5                   10                  15      


Lys Ser Gly Gly Ser Ser Lys Asn Leu Gly Gly Lys Ser Ser Gly Arg 
            20                  25                  30          


Arg Gln Gly Ile Lys Lys Met Glu Gly His Tyr Val His Ala Gly Asn 
        35                  40                  45              


Ile Ile Ala Thr Gln Arg His Phe Arg Trp His Pro Gly Ala His Val 
    50                  55                  60                  


Cys Val Leu Gln Val Gly Val Gly Lys Asn Lys Cys Leu Tyr Ala Leu 
65                  70                  75                  80  


Glu Glu Gly Ile Val Arg Tyr Thr Lys Glu Val Tyr Val Pro His Pro 
                85                  90                  95      


Arg Asn Thr Glu Ala Val Asp Leu Ile Thr Arg Leu Pro Lys Gly Ala 
            100                 105                 110         


Val Leu Tyr Lys Thr Phe Val His Val Val Pro Ala Lys Pro Glu Gly 
        115                 120                 125             


Thr Phe Lys Leu Val Ala Met Leu 
    130                 135     


<210>  8885
<211>  188
<212>  PRT
<213>  Homo Sapiens

<400>  8885

Met Ala Leu Ala Met Leu Val Leu Val Val Ser Pro Trp Ser Ala Ala 
1               5                   10                  15      


Arg Gly Val Leu Arg Asn Tyr Trp Glu Arg Leu Leu Arg Lys Leu Pro 
            20                  25                  30          


Gln Ser Arg Pro Gly Phe Pro Ser Pro Pro Trp Gly Pro Ala Leu Ala 
        35                  40                  45              


Val Gln Gly Pro Ala Met Phe Thr Glu Pro Ala Asn Asp Thr Ser Gly 
    50                  55                  60                  


Ser Lys Glu Asn Ser Ser Leu Leu Asp Ser Ile Phe Trp Met Ala Ala 
65                  70                  75                  80  


Pro Lys Asn Arg Arg Thr Ile Glu Val Asn Arg Cys Arg Arg Arg Asn 
                85                  90                  95      


Pro Gln Lys Leu Ile Lys Val Lys Asn Asn Ile Asp Val Cys Pro Glu 
            100                 105                 110         


Cys Gly His Leu Lys Gln Lys His Val Leu Cys Ala Tyr Cys Tyr Glu 
        115                 120                 125             


Lys Val Cys Lys Glu Thr Ala Glu Ile Arg Arg Gln Ile Gly Lys Gln 
    130                 135                 140                 


Glu Gly Gly Pro Phe Lys Ala Pro Thr Ile Glu Thr Val Val Leu Tyr 
145                 150                 155                 160 


Thr Gly Glu Thr Pro Ser Glu Gln Asp Gln Gly Lys Arg Ile Ile Glu 
                165                 170                 175     


Arg Asp Arg Lys Arg Pro Ser Trp Phe Thr Gln Asn 
            180                 185             


<210>  8886
<211>  107
<212>  PRT
<213>  Homo Sapiens

<400>  8886

Met Ala Leu Ala Met Leu Val Leu Val Val Ser Pro Trp Ser Ala Ala 
1               5                   10                  15      


Arg Gly Val Leu Arg Asn Tyr Trp Glu Arg Leu Leu Arg Lys Leu Pro 
            20                  25                  30          


Gln Ser Arg Pro Gly Phe Pro Ser Pro Pro Trp Gly Pro Ala Leu Ala 
        35                  40                  45              


Val Gln Gly Pro Ala Met Phe Thr Glu Pro Ala Asn Asp Thr Ser Gly 
    50                  55                  60                  


Ser Lys Glu Asn Ser Ser Leu Leu Asp Ser Ile Phe Trp Met Ala Ala 
65                  70                  75                  80  


Pro Lys Asn Arg Arg Thr Ile Glu Val Asn Arg Cys Arg Arg Arg Asn 
                85                  90                  95      


Pro Gln Lys Leu Ile Lys Val Lys Val Met His 
            100                 105         


<210>  8887
<211>  42
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8887

Xaa Glu Asn Ser Ser Leu Leu Asp Ser Ile Phe Trp Met Ala Ala Pro 
1               5                   10                  15      


Lys Asn Arg Arg Thr Ile Glu Val Asn Arg Cys Arg Arg Arg Asn Pro 
            20                  25                  30          


Gln Lys Leu Ile Lys Val Lys Ser Ser Cys 
        35                  40          


<210>  8888
<211>  36
<212>  PRT
<213>  Homo Sapiens

<400>  8888

Met Ala Val Leu Ala Gly Ser Leu Leu Gly Pro Thr Ser Arg Leu Ala 
1               5                   10                  15      


Gly Met Ser Ile Ser Arg Ala Thr Ser Asn Ala Arg Thr Ser Thr Ala 
            20                  25                  30          


Gly Ser Gly Ala 
        35      


<210>  8889
<211>  92
<212>  PRT
<213>  Homo Sapiens

<400>  8889

Met Ala Val Leu Ala Gly Ser Leu Leu Gly Pro Thr Ser Arg Ser Ala 
1               5                   10                  15      


Ala Leu Leu Gly Gly Arg Trp Leu Gln Pro Arg Ala Trp Leu Gly Phe 
            20                  25                  30          


Pro Asp Ala Trp Gly Leu Pro Thr Pro Gln Gln Ala Arg Gly Lys Ala 
        35                  40                  45              


Arg Gly Asn Glu Tyr Gln Pro Ser Asn Ile Lys Arg Lys Asn Lys His 
    50                  55                  60                  


Gly Trp Val Arg Arg Leu Ser Thr Pro Ala Gly Val Gln Val Ile Leu 
65                  70                  75                  80  


Arg Arg Met Leu Lys Gly Arg Lys Ser Leu Ser His 
                85                  90          


<210>  8890
<211>  92
<212>  PRT
<213>  Homo Sapiens

<400>  8890

Met Ala Val Leu Ala Gly Ser Leu Leu Gly Pro Thr Ser Arg Ser Ala 
1               5                   10                  15      


Ala Leu Leu Gly Gly Arg Trp Leu Gln Pro Arg Ala Trp Leu Gly Phe 
            20                  25                  30          


Pro Asp Ala Trp Gly Leu Pro Thr Pro Gln Gln Ala Arg Gly Lys Ala 
        35                  40                  45              


Arg Gly Asn Glu Tyr Gln Pro Ser Asn Ile Lys Arg Lys Asn Lys His 
    50                  55                  60                  


Gly Trp Val Arg Arg Leu Ser Thr Pro Ala Gly Val Gln Val Ile Leu 
65                  70                  75                  80  


Arg Arg Met Leu Lys Gly Arg Lys Ser Leu Ser His 
                85                  90          


<210>  8891
<211>  92
<212>  PRT
<213>  Homo Sapiens

<400>  8891

Met Ala Val Leu Ala Gly Ser Leu Leu Gly Pro Thr Ser Arg Ser Ala 
1               5                   10                  15      


Ala Leu Leu Gly Gly Arg Trp Leu Gln Pro Arg Ala Trp Leu Gly Phe 
            20                  25                  30          


Pro Asp Ala Trp Gly Leu Pro Thr Pro Gln Gln Ala Arg Gly Lys Ala 
        35                  40                  45              


Arg Gly Asn Glu Tyr Gln Pro Ser Asn Ile Lys Arg Lys Asn Lys His 
    50                  55                  60                  


Gly Trp Val Arg Arg Leu Ser Thr Pro Ala Gly Val Gln Val Ile Leu 
65                  70                  75                  80  


Arg Arg Met Leu Lys Gly Arg Lys Ser Leu Ser His 
                85                  90          


<210>  8892
<211>  184
<212>  PRT
<213>  Homo Sapiens

<400>  8892

Met Pro Arg Arg Pro Ser Gly Tyr Phe Leu Ser Ser Gly Gly Ala Gly 
1               5                   10                  15      


Ser Gly Ser Gly Arg Ala Leu Gly Glu Gly Ser Gly Ser Gln Ser Arg 
            20                  25                  30          


Asn Ser Trp Ser Ser Val Leu Thr Val Ser Gly His Ser Ser Ile Thr 
        35                  40                  45              


Met Trp Leu Pro Ser Ser Met Ser Phe Arg Asn Ala Arg Ser Arg Ile 
    50                  55                  60                  


Cys Arg Arg Arg Arg Ala Gln Gly Leu Glu Arg Leu Trp Ala Pro Glu 
65                  70                  75                  80  


Ser Pro Ala Ala Gly Thr Ala Gly Pro Thr Ala Asp Met Ala Val Leu 
                85                  90                  95      


Ala Gly Ser Leu Leu Gly Pro Thr Ser Arg Ser Ala Ala Leu Leu Gly 
            100                 105                 110         


Gly Arg Trp Leu Gln Pro Arg Ala Trp Leu Gly Phe Pro Asp Ala Trp 
        115                 120                 125             


Gly Leu Pro Thr Pro Gln Gln Ala Arg Gly Lys Ala Arg Gly Asn Glu 
    130                 135                 140                 


Tyr Gln Pro Ser Asn Ile Lys Arg Lys Asn Lys His Gly Trp Val Arg 
145                 150                 155                 160 


Arg Leu Ser Thr Pro Ala Gly Val Gln Val Ile Leu Arg Arg Met Leu 
                165                 170                 175     


Lys Gly Arg Lys Ser Leu Ser His 
            180                 


<210>  8893
<211>  95
<212>  PRT
<213>  Homo Sapiens

<400>  8893

Met Ala Ala Ser Ala Phe Ala Gly Ala Val Arg Ala Ala Ser Gly Ile 
1               5                   10                  15      


Leu Arg Pro Leu Asn Ile Leu Ala Ser Ser Thr Tyr Arg Asn Cys Val 
            20                  25                  30          


Lys Asn Ala Ser Leu Ile Ser Ala Leu Ser Thr Gly Arg Phe Ser His 
        35                  40                  45              


Ile Gln Thr Pro Val Val Ser Ser Thr Pro Arg Leu Thr Thr Ser Glu 
    50                  55                  60                  


Arg Asn Leu Thr Cys Gly His Thr Ser Val Ile Leu Asn Arg Leu Ala 
65                  70                  75                  80  


Ile Arg Lys Asn Tyr Gly Lys Arg His Leu Gln Gly Arg Ser Asp 
                85                  90                  95  


<210>  8894
<211>  170
<212>  PRT
<213>  Homo Sapiens

<400>  8894

Met Ala Ala Ser Ala Phe Ala Gly Ala Val Arg Ala Ala Ser Gly Ile 
1               5                   10                  15      


Leu Arg Pro Leu Asn Ile Leu Ala Ser Ser Thr Tyr Arg Asn Cys Val 
            20                  25                  30          


Lys Asn Ala Ser Leu Ile Ser Ala Leu Ser Thr Gly Arg Phe Ser His 
        35                  40                  45              


Ile Gln Thr Pro Val Val Ser Ser Thr Pro Arg Leu Thr Thr Ser Glu 
    50                  55                  60                  


Arg Asn Leu Thr Cys Gly His Thr Ser Val Ile Leu Asn Arg Met Ala 
65                  70                  75                  80  


Pro Val Leu Pro Ser Val Leu Lys Leu Pro Val Arg Ser Leu Thr Tyr 
                85                  90                  95      


Phe Ser Ala Arg Lys Gly Lys Arg Lys Thr Val Lys Ala Val Ile Asp 
            100                 105                 110         


Arg Phe Leu Arg Leu His Cys Gly Leu Trp Val Arg Arg Lys Ala Gly 
        115                 120                 125             


Tyr Lys Lys Lys Leu Trp Lys Lys Thr Pro Ala Arg Lys Lys Arg Leu 
    130                 135                 140                 


Arg Glu Phe Val Phe Cys Asn Lys Thr Gln Ser Lys Leu Leu Asp Lys 
145                 150                 155                 160 


Met Thr Thr Ser Phe Trp Lys Arg Arg Asn 
                165                 170 


<210>  8895
<211>  177
<212>  PRT
<213>  Homo Sapiens

<400>  8895

Met Ala Ala Ser Ala Phe Ala Gly Ala Val Arg Ala Ala Ser Gly Ile 
1               5                   10                  15      


Leu Arg Pro Leu Asn Ile Leu Ala Ser Ser Thr Tyr Arg Asn Cys Val 
            20                  25                  30          


Lys Asn Ala Ser Leu Ile Ser Ala Leu Ser Thr Gly Arg Phe Ser His 
        35                  40                  45              


Ile Gln Thr Pro Val Val Ser Ser Thr Pro Arg Leu Thr Thr Ser Glu 
    50                  55                  60                  


Arg Asn Leu Thr Cys Gly His Thr Ser Val Ile Leu Asn Arg Met Ala 
65                  70                  75                  80  


Pro Val Leu Pro Ser Val Leu Lys Leu Pro Val Arg Ser Leu Thr Tyr 
                85                  90                  95      


Phe Ser Ala Arg Lys Gly Lys Arg Lys Thr Val Lys Ala Val Ile Asp 
            100                 105                 110         


Arg Phe Leu Arg Leu His Cys Gly Leu Trp Val Arg Arg Lys Ala Gly 
        115                 120                 125             


Tyr Lys Lys Lys Leu Trp Lys Lys Thr Pro Ala Arg Lys Lys Arg Leu 
    130                 135                 140                 


Arg Glu Phe Val Phe Cys Asn Lys Thr Gln Ser Lys Leu Leu Asp Lys 
145                 150                 155                 160 


Met Thr Thr Ser Phe Trp Lys Arg Arg Asn Trp His Ser Pro Ile Cys 
                165                 170                 175     


Arg 
    


<210>  8896
<211>  188
<212>  PRT
<213>  Homo Sapiens

<400>  8896

Met Ala Ala Ser Ala Phe Ala Gly Ala Val Arg Ala Ala Ser Gly Ile 
1               5                   10                  15      


Leu Arg Pro Leu Asn Ile Leu Ala Ser Ser Thr Tyr Arg Asn Cys Val 
            20                  25                  30          


Lys Asn Ala Ser Leu Ile Ser Ala Leu Ser Thr Gly Arg Phe Ser His 
        35                  40                  45              


Ile Gln Thr Pro Val Val Ser Ser Thr Pro Arg Leu Thr Thr Ser Glu 
    50                  55                  60                  


Arg Asn Leu Thr Cys Gly His Thr Ser Val Ile Leu Asn Arg Met Ala 
65                  70                  75                  80  


Pro Val Leu Pro Ser Val Leu Lys Leu Pro Val Arg Ser Leu Thr Tyr 
                85                  90                  95      


Phe Ser Ala Arg Lys Gly Lys Arg Lys Thr Val Lys Ala Val Ile Asp 
            100                 105                 110         


Arg Phe Leu Arg Leu His Cys Gly Leu Trp Val Arg Arg Lys Ala Gly 
        115                 120                 125             


Tyr Lys Lys Lys Leu Trp Lys Lys Thr Pro Ala Arg Lys Lys Arg Leu 
    130                 135                 140                 


Arg Glu Phe Val Phe Cys Asn Lys Thr Gln Ser Lys Leu Leu Asp Lys 
145                 150                 155                 160 


Met Thr Thr Ser Phe Trp Lys Arg Arg Asn Trp Tyr Val Asp Asp Pro 
                165                 170                 175     


Tyr Gln Lys Tyr His Asp Arg Thr Asn Leu Lys Val 
            180                 185             


<210>  8897
<211>  122
<212>  PRT
<213>  Homo Sapiens

<400>  8897

Met Ala Ala Leu Gly Thr Val Leu Phe Ser Val Arg Arg Leu His Cys 
1               5                   10                  15      


Ser Val Ala Ala Trp Ala Gly Gly Gln Trp Arg Leu Gln Gln Gly Leu 
            20                  25                  30          


Ala Ala Asn Pro Ser Gly Tyr Gly Pro Leu Thr Glu Leu Pro Asp Trp 
        35                  40                  45              


Ser Tyr Ala Asp Gly Arg Pro Ala Pro Pro Met Lys Gly Gln Leu Arg 
    50                  55                  60                  


Arg Lys Ala Glu Arg Glu Thr Phe Ala Arg Arg Val Val Leu Leu Ser 
65                  70                  75                  80  


Gln Glu Met Asp Ala Gly Leu Gln Ala Trp Gln Leu Arg Gln Gln Lys 
                85                  90                  95      


Leu Gln Glu Glu Gln Arg Lys Gln Glu Asn Ala Leu Lys Pro Lys Gly 
            100                 105                 110         


Ala Ser Leu Lys Ser Pro Leu Pro Ser Gln 
        115                 120         


<210>  8898
<211>  110
<212>  PRT
<213>  Homo Sapiens

<400>  8898

Met Ala Ala Leu Gly Thr Val Leu Phe Ser Val Arg Arg Leu His Cys 
1               5                   10                  15      


Ser Val Ala Ala Trp Ala Gly Gly Gln Trp Arg Leu Gln Gln Gly Leu 
            20                  25                  30          


Ala Ala Asn Pro Ser Gly Tyr Gly Pro Leu Thr Glu Leu Pro Asp Trp 
        35                  40                  45              


Ser Tyr Ala Asp Gly Arg Pro Ala Pro Pro Met Lys Gly Gln Leu Arg 
    50                  55                  60                  


Arg Lys Ala Glu Arg Glu Thr Phe Ala Val Ser Glu Thr Ser Cys Thr 
65                  70                  75                  80  


Ala Val Thr Gly Asn Gly Arg Trp Ile Thr Ser Met Ala Ala Gln Ala 
                85                  90                  95      


Ala Glu Val Ala Gly Arg Thr Lys Glu Ala Gly Lys Cys Ser 
            100                 105                 110 


<210>  8899
<211>  72
<212>  PRT
<213>  Homo Sapiens

<400>  8899

Met Ala Ala Leu Gly Thr Val Leu Phe Ser Val Arg Arg Leu His Cys 
1               5                   10                  15      


Ser Val Ala Ala Trp Ala Gly Gly Gln Trp Arg Leu Gln Gln Gly Leu 
            20                  25                  30          


Ala Ala Asn Pro Ser Gly Tyr Gly Pro Leu Thr Glu Leu Pro Asp Trp 
        35                  40                  45              


Ser Tyr Ala Glu Thr Ser Cys Thr Ala Val Thr Gly Asn Gly Arg Trp 
    50                  55                  60                  


Ile Thr Ser Met Ala Ala Gln Ala 
65                  70          


<210>  8900
<211>  123
<212>  PRT
<213>  Homo Sapiens

<400>  8900

Met Ala Ala Leu Gly Thr Val Leu Phe Thr Gly Val Arg Arg Leu His 
1               5                   10                  15      


Cys Ser Val Ala Ala Trp Ala Gly Gly Gln Trp Arg Leu Gln Gln Gly 
            20                  25                  30          


Leu Ala Ala Asn Pro Ser Gly Tyr Gly Pro Leu Thr Glu Leu Pro Asp 
        35                  40                  45              


Trp Ser Tyr Ala Asp Gly Arg Pro Ala Pro Pro Met Lys Gly Gln Leu 
    50                  55                  60                  


Arg Arg Lys Ala Glu Arg Glu Thr Phe Ala Arg Arg Val Val Leu Leu 
65                  70                  75                  80  


Ser Gln Glu Met Asp Ala Gly Leu Gln Ala Trp Gln Leu Arg Gln Gln 
                85                  90                  95      


Lys Leu Gln Glu Glu Gln Arg Lys Gln Glu Asn Ala Leu Lys Pro Lys 
            100                 105                 110         


Gly Ala Ser Leu Lys Ser Pro Leu Pro Ser Gln 
        115                 120             


<210>  8901
<211>  87
<212>  PRT
<213>  Homo Sapiens

<400>  8901

Met Ala Ala Leu Gly Thr Val Leu Phe Thr Gly Val Arg Arg Leu His 
1               5                   10                  15      


Cys Ser Val Ala Ala Trp Ala Gly Gly Gln Trp Arg Leu Gln Gln Gly 
            20                  25                  30          


Leu Ala Ala Asn Pro Ser Gly Tyr Gly Pro Leu Thr Glu Leu Pro Asp 
        35                  40                  45              


Trp Ser Tyr Ala Glu Thr Ser Cys Thr Ala Val Thr Gly Asn Gly Arg 
    50                  55                  60                  


Trp Ile Thr Ser Met Ala Ala Gln Ala Ala Glu Val Ala Gly Arg Thr 
65                  70                  75                  80  


Lys Glu Ala Gly Lys Cys Ser 
                85          


<210>  8902
<211>  64
<212>  PRT
<213>  Homo Sapiens

<400>  8902

Met Lys Gly Gln Leu Arg Arg Lys Ala Glu Arg Glu Thr Phe Ala Arg 
1               5                   10                  15      


Arg Val Val Leu Leu Ser Gln Glu Met Asp Ala Gly Leu Gln Ala Trp 
            20                  25                  30          


Gln Leu Arg Gln Gln Lys Leu Gln Glu Glu Gln Arg Lys Gln Glu Asn 
        35                  40                  45              


Ala Leu Lys Pro Lys Gly Ala Ser Leu Lys Ser Pro Leu Pro Ser Gln 
    50                  55                  60                  


<210>  8903
<211>  64
<212>  PRT
<213>  Homo Sapiens

<400>  8903

Met Lys Gly Gln Leu Arg Arg Lys Ala Glu Arg Glu Thr Phe Ala Arg 
1               5                   10                  15      


Arg Val Val Leu Leu Ser Gln Glu Met Asp Ala Gly Leu Gln Ala Trp 
            20                  25                  30          


Gln Leu Arg Gln Gln Lys Leu Gln Glu Glu Gln Arg Lys Gln Glu Asn 
        35                  40                  45              


Ala Leu Lys Pro Lys Gly Ala Ser Leu Lys Ser Pro Leu Pro Ser Gln 
    50                  55                  60                  


<210>  8904
<211>  64
<212>  PRT
<213>  Homo Sapiens

<400>  8904

Met Lys Gly Gln Leu Arg Arg Lys Ala Glu Arg Glu Thr Phe Ala Arg 
1               5                   10                  15      


Arg Val Val Leu Leu Ser Gln Glu Met Asp Ala Gly Leu Gln Ala Trp 
            20                  25                  30          


Gln Leu Arg Gln Gln Lys Leu Gln Glu Glu Gln Arg Lys Gln Glu Asn 
        35                  40                  45              


Ala Leu Lys Pro Lys Gly Ala Ser Leu Lys Ser Pro Leu Pro Ser Gln 
    50                  55                  60                  


<210>  8905
<211>  52
<212>  PRT
<213>  Homo Sapiens

<400>  8905

Met Lys Gly Gln Leu Arg Arg Lys Ala Glu Arg Glu Thr Phe Ala Val 
1               5                   10                  15      


Ser Glu Thr Ser Cys Thr Ala Val Thr Gly Asn Gly Arg Trp Ile Thr 
            20                  25                  30          


Ser Met Ala Ala Gln Ala Ala Glu Val Ala Gly Arg Thr Lys Glu Ala 
        35                  40                  45              


Gly Lys Cys Ser 
    50          


<210>  8906
<211>  51
<212>  PRT
<213>  Homo Sapiens

<400>  8906

Met Arg Arg Arg Val Val Leu Leu Ser Gln Glu Met Asp Ala Gly Leu 
1               5                   10                  15      


Gln Ala Trp Gln Leu Arg Gln Gln Lys Leu Gln Glu Glu Gln Arg Lys 
            20                  25                  30          


Gln Glu Asn Ala Leu Lys Pro Lys Gly Ala Ser Leu Lys Ser Pro Leu 
        35                  40                  45              


Pro Ser Gln 
    50      


<210>  8907
<211>  52
<212>  PRT
<213>  Homo Sapiens

<400>  8907

Met Val Lys Ile Phe Ser Thr Cys Tyr Leu Leu Asp Glu Leu Tyr Cys 
1               5                   10                  15      


Cys His Arg Lys Trp Thr Leu Asp Tyr Lys His Gly Ser Ser Gly Ser 
            20                  25                  30          


Arg Ser Cys Arg Lys Asn Lys Gly Ser Arg Lys Met Leu Leu Asn Pro 
        35                  40                  45              


Lys Gly Leu His 
    50          


<210>  8908
<211>  5
<212>  PRT
<213>  Homo Sapiens

<400>  8908

Met Ala Ala Val Gly 
1               5   


<210>  8909
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  8909

Met Ala Ala Val Gly Ser Leu Leu Gly 
1               5                   


<210>  8910
<211>  164
<212>  PRT
<213>  Homo Sapiens

<400>  8910

Met Ala Ala Val Gly Ser Leu Leu Gly Leu Ala Ala Ser Ser Trp Leu 
1               5                   10                  15      


Gly Gly Gln Asn Ala Ser Asp His Ser Leu Trp Leu Leu Arg Lys Pro 
            20                  25                  30          


Arg Gly Ser Ser Cys Pro Gly Thr Gly His Gln Leu Cys Arg Leu Arg 
        35                  40                  45              


Gln Ser Thr Val Lys Ala Thr Gly Pro Ala Leu Arg Arg Leu His Thr 
    50                  55                  60                  


Ser Ser Trp Arg Ala Asp Ser Ser Arg Ala Ser Leu Thr Arg Val His 
65                  70                  75                  80  


Arg Gln Ala Tyr Ala Arg Leu Tyr Pro Val Leu Leu Val Lys Gln Asp 
                85                  90                  95      


Gly Ser Thr Ile His Ile Arg Tyr Arg Glu Pro Arg Arg Met Leu Ala 
            100                 105                 110         


Met Pro Ile Asp Leu Asp Thr Leu Ser Pro Glu Glu Arg Arg Ala Arg 
        115                 120                 125             


Leu Arg Lys Arg Glu Ala Gln Leu Gln Ser Arg Lys Glu Tyr Glu Gln 
    130                 135                 140                 


Glu Leu Ser Asp Asp Leu His Val Glu Arg Tyr Arg Gln Phe Trp Thr 
145                 150                 155                 160 


Arg Thr Lys Lys 
                


<210>  8911
<211>  164
<212>  PRT
<213>  Homo Sapiens

<400>  8911

Met Ala Ala Val Gly Ser Leu Leu Gly Leu Ala Ala Ser Ser Trp Leu 
1               5                   10                  15      


Gly Gly Gln Asn Ala Ser Asp His Ser Leu Trp Leu Leu Arg Lys Pro 
            20                  25                  30          


Arg Gly Ser Ser Cys Pro Gly Thr Gly His Gln Leu Cys Arg Leu Arg 
        35                  40                  45              


Gln Ser Thr Val Lys Ala Thr Gly Pro Ala Leu Arg Arg Leu His Thr 
    50                  55                  60                  


Ser Ser Trp Arg Ala Asp Ser Ser Arg Ala Ser Leu Thr Arg Val His 
65                  70                  75                  80  


Arg Gln Ala Tyr Ala Arg Leu Tyr Pro Val Leu Leu Val Lys Gln Asp 
                85                  90                  95      


Gly Ser Thr Ile His Ile Arg Tyr Arg Glu Pro Arg Arg Met Leu Ala 
            100                 105                 110         


Met Pro Ile Asp Leu Asp Thr Leu Ser Pro Glu Glu Arg Arg Ala Arg 
        115                 120                 125             


Leu Arg Lys Arg Glu Ala Gln Leu Gln Ser Arg Lys Glu Tyr Glu Gln 
    130                 135                 140                 


Glu Leu Ser Asp Asp Leu His Val Glu Arg Tyr Arg Gln Phe Trp Thr 
145                 150                 155                 160 


Arg Thr Lys Lys 
                


<210>  8912
<211>  24
<212>  PRT
<213>  Homo Sapiens

<400>  8912

Met Ala Ala Val Gly Ser Leu Leu Gly Arg Leu Arg Gln Ser Thr Val 
1               5                   10                  15      


Lys Ala Thr Gly Pro Ala Leu Arg 
            20                  


<210>  8913
<211>  43
<212>  PRT
<213>  Homo Sapiens

<400>  8913

Met Ala Ala Val Gly Ser Leu Leu Gly Arg Leu Arg Gln Ser Thr Val 
1               5                   10                  15      


Lys Ala Thr Gly Pro Ala Leu Arg Arg Leu His Thr Ser Ser Trp Arg 
            20                  25                  30          


Ala Asp Ser Ser Arg Ala Ser Leu Thr Arg Val 
        35                  40              


<210>  8914
<211>  76
<212>  PRT
<213>  Homo Sapiens

<400>  8914

Met Ala Ala Val Gly Ser Leu Leu Gly Arg Leu Arg Gln Ser Thr Val 
1               5                   10                  15      


Lys Ala Thr Gly Pro Ala Leu Arg Arg Leu His Thr Ser Ser Trp Arg 
            20                  25                  30          


Ala Asp Ser Ser Arg Ala Ser Leu Thr Arg Val His Arg Gln Ala Tyr 
        35                  40                  45              


Ala Arg Leu Tyr Pro Val Leu Leu Val Lys Gln Asp Gly Ser Thr Ile 
    50                  55                  60                  


His Ile Arg Tyr Arg Glu Pro Arg Arg Met Leu Ala 
65                  70                  75      


<210>  8915
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  8915

Met Ala Ala Val Gly Ser Leu Leu Gly Arg Leu Arg Gln Ser Thr Val 
1               5                   10                  15      


Lys Ala Thr Gly Pro Ala Leu Arg Arg Leu His Thr Ser Ser Trp Arg 
            20                  25                  30          


Ala Asp Ser Ser Arg Ala Ser Leu Thr Arg Val His Arg Gln Ala Tyr 
        35                  40                  45              


Ala Arg Leu Tyr Pro Val Leu Leu Val Lys Gln Asp Gly Ser Thr Ile 
    50                  55                  60                  


His Ile Arg Tyr Arg Glu Pro Arg Arg Met Leu Ala Met Pro Ile Asp 
65                  70                  75                  80  


Leu Asp Thr Leu Ser Pro Glu Glu Arg Arg Ala Arg Leu Arg Lys Arg 
                85                  90                  95      


Glu Ala Gln Leu Gln Ser Arg Lys Glu Tyr Glu Gln Glu Leu Ser Asp 
            100                 105                 110         


Asp Leu His Val Glu Arg Tyr Arg Gln Phe Trp Thr Arg Thr Lys Lys 
        115                 120                 125             


<210>  8916
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  8916

Met Ala Ala Val Gly Ser Leu Leu Gly Arg Leu Arg Gln Ser Thr Val 
1               5                   10                  15      


Lys Ala Thr Gly Pro Ala Leu Arg Arg Leu His Thr Ser Ser Trp Arg 
            20                  25                  30          


Ala Asp Ser Ser Arg Ala Ser Leu Thr Arg Val His Arg Gln Ala Tyr 
        35                  40                  45              


Ala Arg Leu Tyr Pro Val Leu Leu Val Lys Gln Asp Gly Ser Thr Ile 
    50                  55                  60                  


His Ile Arg Tyr Arg Glu Pro Arg Arg Met Leu Ala Met Pro Ile Asp 
65                  70                  75                  80  


Leu Asp Thr Leu Ser Pro Glu Glu Arg Arg Ala Arg Leu Arg Lys Arg 
                85                  90                  95      


Glu Ala Gln Leu Gln Ser Arg Lys Glu Tyr Glu Gln Glu Leu Ser Asp 
            100                 105                 110         


Asp Leu His Val Glu Arg Tyr Arg Gln Phe Trp Thr Arg Thr Lys Lys 
        115                 120                 125             


<210>  8917
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  8917

Met Ala Ala Val Gly Ser Leu Leu Gly Arg Leu Arg Gln Ser Thr Val 
1               5                   10                  15      


Lys Ala Thr Gly Pro Ala Leu Arg Arg Leu His Thr Ser Ser Trp Arg 
            20                  25                  30          


Ala Asp Ser Ser Arg Ala Ser Leu Thr Arg Val His Arg Gln Ala Tyr 
        35                  40                  45              


Ala Arg Leu Tyr Pro Val Leu Leu Val Lys Gln Asp Gly Ser Thr Ile 
    50                  55                  60                  


His Ile Arg Tyr Arg Glu Pro Arg Arg Met Leu Ala Met Pro Ile Asp 
65                  70                  75                  80  


Leu Asp Thr Leu Ser Pro Glu Glu Arg Arg Ala Arg Leu Arg Lys Arg 
                85                  90                  95      


Glu Ala Gln Leu Gln Ser Arg Lys Glu Tyr Glu Gln Glu Leu Ser Asp 
            100                 105                 110         


Asp Leu His Val Glu Arg Tyr Arg Gln Phe Trp Thr Arg Thr Lys Lys 
        115                 120                 125             


<210>  8918
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  8918

Met Ala Ala Val Gly Ser Leu Leu Gly Arg Leu Arg Gln Ser Thr Val 
1               5                   10                  15      


Lys Ala Thr Gly Pro Ala Leu Arg Arg Leu His Thr Ser Ser Trp Arg 
            20                  25                  30          


Ala Asp Ser Ser Arg Ala Ser Leu Thr Arg Val His Arg Gln Ala Tyr 
        35                  40                  45              


Ala Arg Leu Tyr Pro Val Leu Leu Val Lys Gln Asp Gly Ser Thr Ile 
    50                  55                  60                  


His Ile Arg Tyr Arg Glu Pro Arg Arg Met Leu Ala Met Pro Ile Asp 
65                  70                  75                  80  


Leu Asp Thr Leu Ser Pro Glu Glu Arg Arg Ala Arg Leu Arg Lys Arg 
                85                  90                  95      


Glu Ala Gln Leu Gln Ser Arg Lys Glu Tyr Glu Gln Glu Leu Ser Asp 
            100                 105                 110         


Asp Leu His Val Glu Arg Tyr Arg Gln Phe Trp Thr Arg Thr Lys Lys 
        115                 120                 125             


<210>  8919
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  8919

Met Ala Ala Val Gly Ser Leu Leu Gly Arg Leu Arg Gln Ser Thr Val 
1               5                   10                  15      


Lys Ala Thr Gly Pro Ala Leu Arg Arg Leu His Thr Ser Ser Trp Arg 
            20                  25                  30          


Ala Asp Ser Ser Arg Ala Ser Leu Thr Arg Val His Arg Gln Ala Tyr 
        35                  40                  45              


Ala Arg Leu Tyr Pro Val Leu Leu Val Lys Gln Asp Gly Ser Thr Ile 
    50                  55                  60                  


His Ile Arg Tyr Arg Glu Pro Arg Arg Met Leu Ala Met Pro Ile Asp 
65                  70                  75                  80  


Leu Asp Thr Leu Ser Pro Glu Glu Arg Arg Ala Arg Leu Arg Lys Arg 
                85                  90                  95      


Glu Ala Gln Leu Gln Ser Arg Lys Glu Tyr Glu Gln Glu Leu Ser Asp 
            100                 105                 110         


Asp Leu His Val Glu Arg Tyr Arg Gln Phe Trp Thr Arg Thr Lys Lys 
        115                 120                 125             


<210>  8920
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  8920

Met Ala Ala Val Gly Ser Leu Leu Gly Arg Leu Arg Gln Ser Thr Val 
1               5                   10                  15      


Lys Ala Thr Gly Pro Ala Leu Arg Arg Leu His Thr Ser Ser Trp Arg 
            20                  25                  30          


Ala Asp Ser Ser Arg Ala Ser Leu Thr Arg Val His Arg Gln Ala Tyr 
        35                  40                  45              


Ala Arg Leu Tyr Pro Val Leu Leu Val Lys Gln Asp Gly Ser Thr Ile 
    50                  55                  60                  


His Ile Arg Tyr Arg Glu Pro Arg Arg Met Leu Ala Met Pro Ile Asp 
65                  70                  75                  80  


Leu Asp Thr Leu Ser Pro Glu Glu Arg Arg Ala Arg Leu Arg Lys Arg 
                85                  90                  95      


Glu Ala Gln Leu Gln Ser Arg Lys Glu Tyr Glu Gln Glu Leu Ser Asp 
            100                 105                 110         


Asp Leu His Val Glu Arg Tyr Arg Gln Phe Trp Thr Arg Thr Lys Lys 
        115                 120                 125             


<210>  8921
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  8921

Met Ala Ala Val Gly Ser Leu Leu Gly Arg Leu Arg Gln Ser Thr Val 
1               5                   10                  15      


Lys Ala Thr Gly Pro Ala Leu Arg Arg Leu His Thr Ser Ser Trp Arg 
            20                  25                  30          


Ala Asp Ser Ser Arg Ala Ser Leu Thr Arg Val His Arg Gln Ala Tyr 
        35                  40                  45              


Ala Arg Leu Tyr Pro Val Leu Leu Val Lys Gln Asp Gly Ser Thr Ile 
    50                  55                  60                  


His Ile Arg Tyr Arg Glu Pro Arg Arg Met Leu Ala Met Pro Ile Asp 
65                  70                  75                  80  


Leu Asp Thr Leu Ser Pro Glu Glu Arg Arg Ala Arg Leu Arg Lys Arg 
                85                  90                  95      


Glu Ala Gln Leu Gln Ser Arg Lys Glu Tyr Glu Gln Glu Leu Ser Asp 
            100                 105                 110         


Asp Leu His Val Glu Arg Tyr Arg Gln Phe Trp Thr Arg Thr Lys Lys 
        115                 120                 125             


<210>  8922
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  8922

Met Ala Ala Val Gly Ser Leu Leu Gly Arg Leu Arg Gln Ser Thr Val 
1               5                   10                  15      


Lys Ala Thr Gly Pro Ala Leu Arg Arg Leu His Thr Ser Ser Trp Arg 
            20                  25                  30          


Ala Asp Ser Ser Arg Ala Ser Leu Thr Arg Val His Arg Gln Ala Tyr 
        35                  40                  45              


Ala Arg Leu Tyr Pro Val Leu Leu Val Lys Gln Asp Gly Ser Thr Ile 
    50                  55                  60                  


His Ile Arg Tyr Arg Glu Pro Arg Arg Met Leu Ala Met Pro Ile Asp 
65                  70                  75                  80  


Leu Asp Thr Leu Ser Pro Glu Glu Arg Arg Ala Arg Leu Arg Lys Arg 
                85                  90                  95      


Glu Ala Gln Leu Gln Ser Arg Lys Glu Tyr Glu Gln Glu Leu Ser Asp 
            100                 105                 110         


Asp Leu His Val Glu Arg Tyr Arg Gln Phe Trp Thr Arg Thr Lys Lys 
        115                 120                 125             


<210>  8923
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  8923

Met Ala Ala Val Gly Ser Leu Leu Gly Arg Leu Arg Gln Ser Thr Val 
1               5                   10                  15      


Lys Ala Thr Gly Pro Ala Leu Arg Arg Leu His Thr Ser Ser Trp Arg 
            20                  25                  30          


Ala Asp Ser Ser Arg Ala Ser Leu Thr Arg Val His Arg Gln Ala Tyr 
        35                  40                  45              


Ala Arg Leu Tyr Pro Val Leu Leu Val Lys Gln Asp Gly Ser Thr Ile 
    50                  55                  60                  


His Ile Arg Tyr Arg Glu Pro Arg Arg Met Leu Ala Met Pro Ile Asp 
65                  70                  75                  80  


Leu Asp Thr Leu Ser Pro Glu Glu Arg Arg Ala Arg Leu Arg Lys Arg 
                85                  90                  95      


Glu Ala Gln Leu Gln Ser Arg Lys Glu Tyr Glu Gln Glu Leu Ser Asp 
            100                 105                 110         


Asp Leu His Val Glu Arg Tyr Arg Gln Phe Trp Thr Arg Thr Lys Lys 
        115                 120                 125             


<210>  8924
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  8924

Met Ala Ala Val Gly Ser Leu Leu Gly Arg Leu Arg Gln Ser Thr Val 
1               5                   10                  15      


Lys Ala Thr Gly Pro Ala Leu Arg Arg Leu His Thr Ser Ser Trp Arg 
            20                  25                  30          


Ala Asp Ser Ser Arg Ala Ser Leu Thr Arg Val His Arg Gln Ala Tyr 
        35                  40                  45              


Ala Arg Leu Tyr Pro Val Leu Leu Val Lys Gln Asp Gly Ser Thr Ile 
    50                  55                  60                  


His Ile Arg Tyr Arg Glu Pro Arg Arg Met Leu Ala Met Pro Ile Asp 
65                  70                  75                  80  


Leu Asp Thr Leu Ser Pro Glu Glu Arg Arg Ala Arg Leu Arg Lys Arg 
                85                  90                  95      


Glu Ala Gln Leu Gln Ser Arg Lys Glu Tyr Glu Gln Glu Leu Ser Asp 
            100                 105                 110         


Asp Leu His Val Glu Arg Tyr Arg Gln Phe Trp Thr Arg Thr Lys Lys 
        115                 120                 125             


<210>  8925
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  8925

Met Ala Ala Val Gly Ser Leu Leu Gly Arg Leu Arg Gln Ser Thr Val 
1               5                   10                  15      


Lys Ala Thr Gly Pro Ala Leu Arg Arg Leu His Thr Ser Ser Trp Arg 
            20                  25                  30          


Ala Asp Ser Ser Arg Ala Ser Leu Thr Arg Val His Arg Gln Ala Tyr 
        35                  40                  45              


Ala Arg Leu Tyr Pro Val Leu Leu Val Lys Gln Asp Gly Ser Thr Ile 
    50                  55                  60                  


His Ile Arg Tyr Arg Glu Pro Arg Arg Met Leu Ala Met Pro Ile Asp 
65                  70                  75                  80  


Leu Asp Thr Leu Ser Pro Glu Glu Arg Arg Ala Arg Leu Arg Lys Arg 
                85                  90                  95      


Glu Ala Gln Leu Gln Ser Arg Lys Glu Tyr Glu Gln Glu Leu Ser Asp 
            100                 105                 110         


Asp Leu His Val Glu Arg Tyr Arg Gln Phe Trp Thr Arg Thr Lys Lys 
        115                 120                 125             


<210>  8926
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  8926

Met Ala Ala Val Gly Ser Leu Leu Gly Arg Leu Arg Gln Ser Thr Val 
1               5                   10                  15      


Lys Ala Thr Gly Pro Ala Leu Arg Arg Leu His Thr Ser Ser Trp Arg 
            20                  25                  30          


Ala Asp Ser Ser Arg Ala Ser Leu Thr Arg Val His Arg Gln Ala Tyr 
        35                  40                  45              


Ala Arg Leu Tyr Pro Val Leu Leu Val Lys Gln Asp Gly Ser Thr Ile 
    50                  55                  60                  


His Ile Arg Tyr Arg Glu Pro Arg Arg Met Leu Ala Met Pro Ile Asp 
65                  70                  75                  80  


Leu Asp Thr Leu Ser Pro Glu Glu Arg Arg Ala Arg Leu Arg Lys Arg 
                85                  90                  95      


Glu Ala Gln Leu Gln Ser Arg Lys Glu Tyr Glu Gln Glu Leu Ser Asp 
            100                 105                 110         


Asp Leu His Val Glu Arg Tyr Arg Gln Phe Trp Thr Arg Thr Lys Lys 
        115                 120                 125             


<210>  8927
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  8927

Met Ala Ala Val Gly Ser Leu Leu Gly Arg Leu Arg Gln Ser Thr Val 
1               5                   10                  15      


Lys Ala Thr Gly Pro Ala Leu Arg Arg Leu His Thr Ser Ser Trp Arg 
            20                  25                  30          


Ala Asp Ser Ser Arg Ala Ser Leu Thr Arg Val His Arg Gln Ala Tyr 
        35                  40                  45              


Ala Arg Leu Tyr Pro Val Leu Leu Val Lys Gln Asp Gly Ser Thr Ile 
    50                  55                  60                  


His Ile Arg Tyr Arg Glu Pro Arg Arg Met Leu Ala Met Pro Ile Asp 
65                  70                  75                  80  


Leu Asp Thr Leu Ser Pro Glu Glu Arg Arg Ala Arg Leu Arg Lys Arg 
                85                  90                  95      


Glu Ala Gln Leu Gln Ser Arg Lys Glu Tyr Glu Gln Glu Leu Ser Asp 
            100                 105                 110         


Asp Leu His Val Glu Arg Tyr Arg Gln Phe Trp Thr Arg Thr Lys Lys 
        115                 120                 125             


<210>  8928
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  8928

Met Ala Ala Val Gly Ser Leu Leu Gly Arg Leu Arg Gln Ser Thr Val 
1               5                   10                  15      


Lys Ala Thr Gly Pro Ala Leu Arg Arg Leu His Thr Ser Ser Trp Arg 
            20                  25                  30          


Ala Asp Ser Ser Arg Ala Ser Leu Thr Arg Val His Arg Gln Ala Tyr 
        35                  40                  45              


Ala Arg Leu Tyr Pro Val Leu Leu Val Lys Gln Asp Gly Ser Thr Ile 
    50                  55                  60                  


His Ile Arg Tyr Arg Glu Pro Arg Arg Met Leu Ala Met Pro Ile Asp 
65                  70                  75                  80  


Leu Asp Thr Leu Ser Pro Glu Glu Arg Arg Ala Arg Leu Arg Lys Arg 
                85                  90                  95      


Glu Ala Gln Leu Gln Ser Arg Lys Glu Tyr Glu Gln Glu Leu Ser Asp 
            100                 105                 110         


Asp Leu His Val Glu Arg Tyr Arg Gln Phe Trp Thr Arg Thr Lys Lys 
        115                 120                 125             


<210>  8929
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  8929

Met Ala Ala Val Gly Ser Leu Leu Gly Arg Leu Arg Gln Ser Thr Val 
1               5                   10                  15      


Lys Ala Thr Gly Pro Ala Leu Arg Arg Leu His Thr Ser Ser Trp Arg 
            20                  25                  30          


Ala Asp Ser Ser Arg Ala Ser Leu Thr Arg Val His Arg Gln Ala Tyr 
        35                  40                  45              


Ala Arg Leu Tyr Pro Val Leu Leu Val Lys Gln Asp Gly Ser Thr Ile 
    50                  55                  60                  


His Ile Arg Tyr Arg Glu Pro Arg Arg Met Leu Ala Met Pro Ile Asp 
65                  70                  75                  80  


Leu Asp Thr Leu Ser Pro Glu Glu Arg Arg Ala Arg Leu Arg Lys Arg 
                85                  90                  95      


Glu Ala Gln Leu Gln Ser Arg Lys Glu Tyr Glu Gln Glu Leu Ser Asp 
            100                 105                 110         


Asp Leu His Val Glu Arg Tyr Arg Gln Phe Trp Thr Arg Thr Lys Lys 
        115                 120                 125             


<210>  8930
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  8930

Met Ala Ala Val Gly Ser Leu Leu Gly Arg Leu Arg Gln Ser Thr Val 
1               5                   10                  15      


Lys Ala Thr Gly Pro Ala Leu Arg Arg Leu His Thr Ser Ser Trp Arg 
            20                  25                  30          


Ala Asp Ser Ser Arg Ala Ser Leu Thr Arg Val His Arg Gln Ala Tyr 
        35                  40                  45              


Ala Arg Leu Tyr Pro Val Leu Leu Val Lys Gln Asp Gly Ser Thr Ile 
    50                  55                  60                  


His Ile Arg Tyr Arg Glu Pro Arg Arg Met Leu Ala Met Pro Ile Asp 
65                  70                  75                  80  


Leu Asp Thr Leu Ser Pro Glu Glu Arg Arg Ala Arg Leu Arg Lys Arg 
                85                  90                  95      


Glu Ala Gln Leu Gln Ser Arg Lys Glu Tyr Glu Gln Glu Leu Ser Asp 
            100                 105                 110         


Asp Leu His Val Glu Arg Tyr Arg Gln Phe Trp Thr Arg Thr Lys Lys 
        115                 120                 125             


<210>  8931
<211>  55
<212>  PRT
<213>  Homo Sapiens

<400>  8931

Met Leu Ala Met Pro Ile Asp Leu Asp Thr Leu Ser Pro Glu Glu Arg 
1               5                   10                  15      


Arg Ala Arg Leu Arg Lys Arg Glu Ala Gln Leu Gln Ser Arg Lys Glu 
            20                  25                  30          


Tyr Glu Gln Glu Leu Ser Asp Asp Leu His Val Glu Arg Tyr Arg Gln 
        35                  40                  45              


Phe Trp Thr Arg Thr Lys Lys 
    50                  55  


<210>  8932
<211>  55
<212>  PRT
<213>  Homo Sapiens

<400>  8932

Met Leu Ala Met Pro Ile Asp Leu Asp Thr Leu Ser Pro Glu Glu Arg 
1               5                   10                  15      


Arg Ala Arg Leu Arg Lys Arg Glu Ala Gln Leu Gln Ser Arg Lys Glu 
            20                  25                  30          


Tyr Glu Gln Glu Leu Ser Asp Asp Leu His Val Glu Arg Tyr Arg Gln 
        35                  40                  45              


Phe Trp Thr Arg Thr Lys Lys 
    50                  55  


<210>  8933
<211>  55
<212>  PRT
<213>  Homo Sapiens

<400>  8933

Met Leu Ala Met Pro Ile Asp Leu Asp Thr Leu Ser Pro Glu Glu Arg 
1               5                   10                  15      


Arg Ala Arg Leu Arg Lys Arg Glu Ala Gln Leu Gln Ser Arg Lys Glu 
            20                  25                  30          


Tyr Glu Gln Glu Leu Ser Asp Asp Leu His Val Glu Arg Tyr Arg Gln 
        35                  40                  45              


Phe Trp Thr Arg Thr Lys Lys 
    50                  55  


<210>  8934
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  8934

Met Ala Ala Phe Met Leu Gly Ser Leu Leu Arg Thr Phe Lys Gln Met 
1               5                   10                  15      


Val Pro Ser Ser Ala Ser Gly Gln Val Arg Ser His Tyr Val Asp Trp 
            20                  25                  30          


Arg Met Trp Arg Asp Val Lys Arg Arg Lys Met Ala Tyr Glu Tyr Ala 
        35                  40                  45              


Asp Glu Arg Leu Arg Ile Asn Ser Leu Arg Lys Asn Thr Ile Leu Pro 
    50                  55                  60                  


Lys Ile Leu Gln Asp Val Ala Asp Glu Glu Ile Ala Ala Leu Pro Arg 
65                  70                  75                  80  


Asp Ser Cys Pro Val Arg Ile Arg Asn Arg Cys Val Met Thr Ser Arg 
                85                  90                  95      


Pro Arg Gly Val Lys Arg Arg Trp Arg Leu Ser Arg Ile Val Phe Arg 
            100                 105                 110         


His Leu Ala Asp His Gly Gln Leu Ser Gly Ile Gln Arg Ala Thr Trp 
        115                 120                 125             


<210>  8935
<211>  60
<212>  PRT
<213>  Homo Sapiens

<400>  8935

Met Ala Ala Phe Met Leu Gly Ser Leu Leu Arg Thr Phe Lys Gln Val 
1               5                   10                  15      


Arg Pro Leu Leu Leu Ser Thr Pro Leu Pro Leu Thr Ala Glu Ser His 
            20                  25                  30          


Asn Pro Arg Val Pro His Gly Ser Ala Thr Cys Ser Ala Arg Trp Phe 
        35                  40                  45              


Leu His Gln Leu Gln Ala Lys Phe Glu Val Thr Met 
    50                  55                  60  


<210>  8936
<211>  200
<212>  PRT
<213>  Homo Sapiens

<400>  8936

Gly Thr Thr Val Leu Leu Trp Ser Leu Leu Arg Ser Ser Pro Gly Val 
1               5                   10                  15      


Glu Arg Val Cys Phe Arg Ala Arg Ile Gln Pro Trp His Gly Gly Leu 
            20                  25                  30          


Leu Gln Pro Leu Pro Cys Ser Phe Glu Met Gly Leu Pro Arg Arg Arg 
        35                  40                  45              


Phe Ser Ser Glu Ala Ala Ser Tyr Leu Leu Lys Ser Ile Leu Ala Glu 
    50                  55                  60                  


Ser Gly Ser Pro Glu Thr Lys Lys Pro Thr Phe Met Asp Glu Glu Val 
65                  70                  75                  80  


Gln Ser Ile Leu Thr Lys Met Thr Gly Leu Asn Leu Gln Lys Thr Phe 
                85                  90                  95      


Lys Pro Ala Ile Gln Glu Leu Lys Pro Pro Thr Tyr Lys Leu Met Thr 
            100                 105                 110         


Gln Ala Gln Leu Glu Glu Ala Thr Arg Gln Ala Val Glu Ala Ala Lys 
        115                 120                 125             


Val Arg Leu Lys Met Pro Pro Val Leu Glu Glu Arg Val Pro Ile Asn 
    130                 135                 140                 


Asp Val Leu Ala Glu Asp Lys Ile Leu Glu Gly Thr Glu Thr Thr Lys 
145                 150                 155                 160 


Tyr Val Phe Thr Asp Ile Ser Tyr Ser Ile Pro His Arg Glu Arg Phe 
                165                 170                 175     


Ile Val Val Arg Glu Pro Ser Gly Thr Leu Arg Lys Ala Ser Trp Glu 
            180                 185                 190         


Glu Arg Asp Arg Met Ile Gln Val 
        195                 200 


<210>  8937
<211>  360
<212>  PRT
<213>  Homo Sapiens

<400>  8937

Met Ala Pro Leu Gly Thr Thr Val Leu Leu Trp Ser Leu Leu Arg Ser 
1               5                   10                  15      


Ser Pro Gly Val Glu Arg Val Cys Phe Arg Ala Arg Ile Gln Pro Trp 
            20                  25                  30          


His Gly Gly Leu Leu Gln Pro Leu Pro Cys Ser Phe Glu Met Gly Leu 
        35                  40                  45              


Pro Arg Arg Arg Phe Ser Ser Glu Ala Ala Glu Ser Gly Ser Pro Glu 
    50                  55                  60                  


Thr Lys Lys Pro Thr Phe Met Asp Glu Glu Val Gln Ser Ile Leu Thr 
65                  70                  75                  80  


Lys Met Thr Gly Leu Asn Leu Gln Lys Thr Phe Lys Pro Ala Ile Gln 
                85                  90                  95      


Glu Leu Lys Pro Pro Thr Tyr Lys Leu Met Thr Gln Ala Gln Leu Glu 
            100                 105                 110         


Glu Ala Thr Arg Gln Ala Val Glu Ala Ala Lys Val Arg Leu Lys Met 
        115                 120                 125             


Pro Pro Val Leu Glu Glu Arg Val Pro Ile Asn Asp Val Leu Ala Glu 
    130                 135                 140                 


Asp Lys Ile Leu Glu Gly Thr Glu Thr Thr Lys Tyr Val Phe Thr Asp 
145                 150                 155                 160 


Ile Ser Tyr Ser Ile Pro His Arg Glu Arg Phe Ile Val Val Arg Glu 
                165                 170                 175     


Pro Ser Gly Thr Leu Arg Lys Ala Ser Trp Glu Glu Arg Asp Arg Met 
            180                 185                 190         


Ile Gln Val Tyr Phe Pro Lys Glu Gly Arg Lys Ile Leu Thr Pro Ile 
        195                 200                 205             


Ile Phe Lys Glu Glu Asn Leu Arg Thr Met Tyr Ser Gln Asp Arg His 
    210                 215                 220                 


Val Asp Val Leu Asn Leu Cys Phe Ala Gln Phe Glu Pro Asp Ser Thr 
225                 230                 235                 240 


Glu Tyr Ile Lys Val His His Lys Thr Tyr Glu Asp Ile Asp Lys Arg 
                245                 250                 255     


Gly Lys Tyr Asp Leu Leu Arg Ser Thr Arg Tyr Phe Gly Gly Met Val 
            260                 265                 270         


Trp Tyr Phe Val Asn Asn Lys Lys Ile Asp Gly Leu Leu Ile Asp Gln 
        275                 280                 285             


Ile Gln Arg Asp Leu Ile Asp Asp Ala Thr Asn Leu Val Gln Leu Tyr 
    290                 295                 300                 


His Val Leu His Pro Asp Gly Gln Ser Ala Gln Gly Ala Lys Asp Gln 
305                 310                 315                 320 


Ala Ala Glu Gly Ile Asn Leu Ile Lys Val Phe Ala Lys Thr Glu Ala 
                325                 330                 335     


Gln Lys Gly Ala Tyr Ile Glu Leu Thr Leu Gln Thr Tyr Gln Glu Ala 
            340                 345                 350         


Leu Ser Arg His Ser Ala Ala Ser 
        355                 360 


<210>  8938
<211>  360
<212>  PRT
<213>  Homo Sapiens

<400>  8938

Met Ala Pro Leu Gly Thr Thr Val Leu Leu Trp Ser Leu Leu Arg Ser 
1               5                   10                  15      


Ser Pro Gly Val Glu Arg Val Cys Phe Arg Ala Arg Ile Gln Pro Trp 
            20                  25                  30          


His Gly Gly Leu Leu Gln Pro Leu Pro Cys Ser Phe Glu Met Gly Leu 
        35                  40                  45              


Pro Arg Arg Arg Phe Ser Ser Glu Ala Ala Glu Ser Gly Ser Pro Glu 
    50                  55                  60                  


Thr Lys Lys Pro Thr Phe Met Asp Glu Glu Val Gln Ser Ile Leu Thr 
65                  70                  75                  80  


Lys Met Thr Gly Leu Asn Leu Gln Lys Thr Phe Lys Pro Ala Ile Gln 
                85                  90                  95      


Glu Leu Lys Pro Pro Thr Tyr Lys Leu Met Thr Gln Ala Gln Leu Glu 
            100                 105                 110         


Glu Ala Thr Arg Gln Ala Val Glu Ala Ala Lys Val Arg Leu Lys Met 
        115                 120                 125             


Pro Pro Val Leu Glu Glu Arg Val Pro Ile Asn Asp Val Leu Ala Glu 
    130                 135                 140                 


Asp Lys Ile Leu Glu Gly Thr Glu Thr Thr Lys Tyr Val Phe Thr Asp 
145                 150                 155                 160 


Ile Ser Tyr Ser Ile Pro His Arg Glu Arg Phe Ile Val Val Arg Glu 
                165                 170                 175     


Pro Ser Gly Thr Leu Arg Lys Ala Ser Trp Glu Glu Arg Asp Arg Met 
            180                 185                 190         


Ile Gln Val Tyr Phe Pro Lys Glu Gly Arg Lys Ile Leu Thr Pro Ile 
        195                 200                 205             


Ile Phe Lys Glu Glu Asn Leu Arg Thr Met Tyr Ser Gln Asp Arg His 
    210                 215                 220                 


Val Asp Val Leu Asn Leu Cys Phe Ala Gln Phe Glu Pro Asp Ser Thr 
225                 230                 235                 240 


Glu Tyr Ile Lys Val His His Lys Thr Tyr Glu Asp Ile Asp Lys Arg 
                245                 250                 255     


Gly Lys Tyr Asp Leu Leu Arg Ser Thr Arg Tyr Phe Gly Gly Met Val 
            260                 265                 270         


Trp Tyr Phe Val Asn Asn Lys Lys Ile Asp Gly Leu Leu Ile Asp Gln 
        275                 280                 285             


Ile Gln Arg Asp Leu Ile Asp Asp Ala Thr Asn Leu Val Gln Leu Tyr 
    290                 295                 300                 


His Val Leu His Pro Asp Gly Gln Ser Ala Gln Gly Ala Lys Asp Gln 
305                 310                 315                 320 


Ala Ala Glu Gly Ile Asn Leu Ile Lys Val Phe Ala Lys Thr Glu Ala 
                325                 330                 335     


Gln Lys Gly Ala Tyr Ile Glu Leu Thr Leu Gln Thr Tyr Gln Glu Ala 
            340                 345                 350         


Leu Ser Arg His Ser Ala Ala Ser 
        355                 360 


<210>  8939
<211>  168
<212>  PRT
<213>  Homo Sapiens

<400>  8939

Met Ala Pro Leu Gly Thr Thr Val Leu Leu Trp Ser Leu Leu Arg Ser 
1               5                   10                  15      


Ser Pro Gly Val Glu Arg Val Cys Phe Arg Ala Arg Ile Gln Pro Trp 
            20                  25                  30          


His Gly Gly Leu Leu Gln Pro Leu Pro Cys Ser Phe Glu Met Gly Leu 
        35                  40                  45              


Pro Arg Arg Arg Phe Ser Ser Glu Ala Glu Ser Gly Ser Pro Glu Thr 
    50                  55                  60                  


Lys Lys Pro Thr Phe Met Asp Glu Glu Val Gln Ser Ile Leu Thr Lys 
65                  70                  75                  80  


Met Thr Gly Leu Asn Leu Gln Lys Thr Phe Lys Pro Ala Ile Gln Glu 
                85                  90                  95      


Leu Lys Pro Pro Thr Tyr Lys Leu Met Thr Gln Ala Gln Leu Glu Glu 
            100                 105                 110         


Ala Thr Arg Gln Ala Val Glu Ala Ala Lys Val Arg Leu Lys Met Pro 
        115                 120                 125             


Pro Val Leu Glu Glu Arg Val Pro Ile Asn Asp Val Leu Ala Glu Asp 
    130                 135                 140                 


Lys Ile Leu Glu Gly Thr Glu Thr Thr Lys Tyr Val Phe Thr Asp Ile 
145                 150                 155                 160 


Ser Tyr Ser Ile Pro His Arg Cys 
                165             


<210>  8940
<211>  359
<212>  PRT
<213>  Homo Sapiens

<400>  8940

Met Ala Pro Leu Gly Thr Thr Val Leu Leu Trp Ser Leu Leu Arg Ser 
1               5                   10                  15      


Ser Pro Gly Val Glu Arg Val Cys Phe Arg Ala Arg Ile Gln Pro Trp 
            20                  25                  30          


His Gly Gly Leu Leu Gln Pro Leu Pro Cys Ser Phe Glu Met Gly Leu 
        35                  40                  45              


Pro Arg Arg Arg Phe Ser Ser Glu Ala Glu Ser Gly Ser Pro Glu Thr 
    50                  55                  60                  


Lys Lys Pro Thr Phe Met Asp Glu Glu Val Gln Ser Ile Leu Thr Lys 
65                  70                  75                  80  


Met Thr Gly Leu Asn Leu Gln Lys Thr Phe Lys Pro Ala Ile Gln Glu 
                85                  90                  95      


Leu Lys Pro Pro Thr Tyr Lys Leu Met Thr Gln Ala Gln Leu Glu Glu 
            100                 105                 110         


Ala Thr Arg Gln Ala Val Glu Ala Ala Lys Val Arg Leu Lys Met Pro 
        115                 120                 125             


Pro Val Leu Glu Glu Arg Val Pro Ile Asn Asp Val Leu Ala Glu Asp 
    130                 135                 140                 


Lys Ile Leu Glu Gly Thr Glu Thr Thr Lys Tyr Val Phe Thr Asp Ile 
145                 150                 155                 160 


Ser Tyr Ser Ile Pro His Arg Glu Arg Phe Ile Val Val Arg Glu Pro 
                165                 170                 175     


Ser Gly Thr Leu Arg Lys Ala Ser Trp Glu Glu Arg Asp Arg Met Ile 
            180                 185                 190         


Gln Val Tyr Phe Pro Lys Glu Gly Arg Lys Ile Leu Thr Pro Ile Ile 
        195                 200                 205             


Phe Lys Glu Glu Asn Leu Arg Thr Met Tyr Ser Gln Asp Arg His Val 
    210                 215                 220                 


Asp Val Leu Asn Leu Cys Phe Ala Gln Phe Glu Pro Asp Ser Thr Glu 
225                 230                 235                 240 


Tyr Ile Lys Val His His Lys Thr Tyr Glu Asp Ile Asp Lys Arg Gly 
                245                 250                 255     


Lys Tyr Asp Leu Leu Arg Ser Thr Arg Tyr Phe Gly Gly Met Val Trp 
            260                 265                 270         


Tyr Phe Val Asn Asn Lys Lys Ile Asp Gly Leu Leu Ile Asp Gln Ile 
        275                 280                 285             


Gln Arg Asp Leu Ile Asp Asp Ala Thr Asn Leu Val Gln Leu Tyr His 
    290                 295                 300                 


Val Leu His Pro Asp Gly Gln Ser Ala Gln Gly Ala Lys Asp Gln Ala 
305                 310                 315                 320 


Ala Glu Gly Ile Asn Leu Ile Lys Val Phe Ala Lys Thr Glu Ala Gln 
                325                 330                 335     


Lys Gly Ala Tyr Ile Glu Leu Thr Leu Gln Thr Tyr Gln Glu Ala Leu 
            340                 345                 350         


Ser Arg His Ser Ala Ala Ser 
        355                 


<210>  8941
<211>  319
<212>  PRT
<213>  Homo Sapiens

<400>  8941

Met Ser Arg Asn Glu Thr Glu His Arg Tyr Leu Gly Thr His Phe Gly 
1               5                   10                  15      


Ala Glu Ser Gly Ser Pro Glu Thr Lys Lys Pro Thr Phe Met Asp Glu 
            20                  25                  30          


Glu Val Gln Ser Ile Leu Thr Lys Met Thr Gly Leu Asn Leu Gln Lys 
        35                  40                  45              


Thr Phe Lys Pro Ala Ile Gln Glu Leu Lys Pro Pro Thr Tyr Lys Leu 
    50                  55                  60                  


Met Thr Gln Ala Gln Leu Glu Glu Ala Thr Arg Gln Ala Val Glu Ala 
65                  70                  75                  80  


Ala Lys Val Arg Leu Lys Met Pro Pro Val Leu Glu Glu Arg Val Pro 
                85                  90                  95      


Ile Asn Asp Val Leu Ala Glu Asp Lys Ile Leu Glu Gly Thr Glu Thr 
            100                 105                 110         


Thr Lys Tyr Val Phe Thr Asp Ile Ser Tyr Ser Ile Pro His Arg Glu 
        115                 120                 125             


Arg Phe Ile Val Val Arg Glu Pro Ser Gly Thr Leu Arg Lys Ala Ser 
    130                 135                 140                 


Trp Glu Glu Arg Asp Arg Met Ile Gln Val Tyr Phe Pro Lys Glu Gly 
145                 150                 155                 160 


Arg Lys Ile Leu Thr Pro Ile Ile Phe Lys Glu Glu Asn Leu Arg Thr 
                165                 170                 175     


Met Tyr Ser Gln Asp Arg His Val Asp Val Leu Asn Leu Cys Phe Ala 
            180                 185                 190         


Gln Phe Glu Pro Asp Ser Thr Glu Tyr Ile Lys Val His His Lys Thr 
        195                 200                 205             


Tyr Glu Asp Ile Asp Lys Arg Gly Lys Tyr Asp Leu Leu Arg Ser Thr 
    210                 215                 220                 


Arg Tyr Phe Gly Gly Met Val Trp Tyr Phe Val Asn Asn Lys Lys Ile 
225                 230                 235                 240 


Asp Gly Leu Leu Ile Asp Gln Ile Gln Arg Asp Leu Ile Asp Asp Ala 
                245                 250                 255     


Thr Asn Leu Val Gln Leu Tyr His Val Leu His Pro Asp Gly Gln Ser 
            260                 265                 270         


Ala Gln Gly Ala Lys Asp Gln Ala Ala Glu Gly Ile Asn Leu Ile Lys 
        275                 280                 285             


Val Phe Ala Lys Thr Glu Ala Gln Lys Gly Ala Tyr Ile Glu Leu Thr 
    290                 295                 300                 


Leu Gln Thr Tyr Gln Glu Ala Leu Ser Arg His Ser Ala Ala Ser 
305                 310                 315                 


<210>  8942
<211>  51
<212>  PRT
<213>  Homo Sapiens

<400>  8942

Met Val Gln Thr Gly Arg Ser Glu Gly Ile Pro Gly Trp Glu Gln Ser 
1               5                   10                  15      


Met Ser Lys Gly Arg Glu Ile Pro Gly Ser Asp Ser Glu Ser Gly Ser 
            20                  25                  30          


Pro Glu Thr Lys Lys Pro Thr Phe Met Asp Glu Glu Val Gln Ser Ile 
        35                  40                  45              


Leu Thr Lys 
    50      


<210>  8943
<211>  121
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8943

Xaa Lys Tyr Val Phe Thr Asp Ile Ser Tyr Ser Ile Pro His Arg Glu 
1               5                   10                  15      


Arg Phe Ile Val Val Arg Glu Pro Ser Gly Thr Leu Arg Lys Ala Ser 
            20                  25                  30          


Trp Glu Glu Arg Asp Arg Met Ile Gln Val Tyr Phe Pro Lys Glu Gly 
        35                  40                  45              


Arg Lys Ile Leu Thr Pro Ile Ile Phe Lys Glu Glu Asn Leu Arg Phe 
    50                  55                  60                  


Glu Pro Asp Ser Thr Glu Tyr Ile Lys Val His His Lys Thr Tyr Glu 
65                  70                  75                  80  


Asp Ile Asp Lys Arg Gly Lys Tyr Asp Leu Leu Arg Ser Thr Arg Tyr 
                85                  90                  95      


Phe Gly Gly Met Val Trp Tyr Phe Val Asn Asn Lys Lys Ile Asp Gly 
            100                 105                 110         


Leu Leu Ile Asp Gln Ile Gln Arg Asp 
        115                 120     


<210>  8944
<211>  165
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8944

Xaa Thr Thr Val Leu Leu Trp Ser Leu Leu Arg Ser Ser Pro Gly Val 
1               5                   10                  15      


Glu Arg Val Cys Phe Arg Ala Arg Ile Gln Pro Trp His Gly Gly Leu 
            20                  25                  30          


Leu Gln Pro Leu Pro Cys Ser Phe Glu Met Gly Leu Pro Arg Arg Arg 
        35                  40                  45              


Phe Ser Ser Glu Ala Ala Glu Ser Gly Ser Pro Glu Thr Lys Lys Pro 
    50                  55                  60                  


Thr Phe Met Asp Glu Glu Val Gln Ser Ile Leu Thr Lys Met Thr Gly 
65                  70                  75                  80  


Leu Asn Leu Gln Lys Thr Phe Lys Pro Ala Ile Gln Glu Leu Lys Pro 
                85                  90                  95      


Pro Thr Tyr Lys Leu Met Thr Gln Ala Gln Leu Glu Glu Ala Thr Arg 
            100                 105                 110         


Gln Ala Val Glu Ala Ala Lys Val Arg Leu Lys Met Pro Pro Val Leu 
        115                 120                 125             


Glu Glu Arg Val Pro Ile Asn Asp Val Leu Ala Glu Asp Lys Ile Leu 
    130                 135                 140                 


Glu Gly Thr Glu Thr Thr Lys Tyr Val Phe Thr Asp Ile Ser Tyr Ser 
145                 150                 155                 160 


Ile Pro His Arg Cys 
                165 


<210>  8945
<211>  86
<212>  PRT
<213>  Homo Sapiens

<400>  8945

Met Ala Ala Leu Cys Arg Thr Arg Ala Val Ala Ala Glu Ser His Phe 
1               5                   10                  15      


Leu Arg Val Phe Leu Phe Phe Arg Pro Phe Arg Gly Val Gly Thr Glu 
            20                  25                  30          


Ser Gly Ser Glu Ser Gly Ser Ser Asn Ala Lys Glu Pro Lys Thr Arg 
        35                  40                  45              


Ala Gly Gly Phe Ala Ser Ala Leu Glu Arg His Ser Glu Leu Leu Gln 
    50                  55                  60                  


Lys Val Glu Pro Leu Gln Lys Glu Ile Pro Glu Arg Asn Gln Gly Pro 
65                  70                  75                  80  


Val Ala Ala Ile Arg Ser 
                85      


<210>  8946
<211>  187
<212>  PRT
<213>  Homo Sapiens

<400>  8946

Met Ala Ala Leu Cys Arg Thr Arg Ala Val Ala Ala Glu Ser His Phe 
1               5                   10                  15      


Leu Arg Val Phe Leu Phe Phe Arg Pro Phe Arg Gly Val Gly Thr Glu 
            20                  25                  30          


Ser Gly Ser Glu Ser Gly Ser Ser Asn Ala Lys Glu Pro Lys Thr Arg 
        35                  40                  45              


Ala Gly Gly Phe Ala Ser Ala Leu Glu Arg His Ser Glu Leu Leu Gln 
    50                  55                  60                  


Lys Val Glu Pro Leu Gln Lys Gly Ser Pro Lys Asn Val Glu Ser Phe 
65                  70                  75                  80  


Ala Ser Met Leu Arg His Ser Pro Leu Thr Gln Met Gly Pro Ala Lys 
                85                  90                  95      


Asp Lys Leu Val Ile Gly Arg Ile Phe His Ile Val Glu Asn Asp Leu 
            100                 105                 110         


Tyr Ile Asp Phe Gly Gly Lys Phe His Cys Val Cys Arg Arg Pro Glu 
        115                 120                 125             


Val Asp Gly Glu Lys Tyr Gln Lys Gly Thr Arg Val Arg Leu Arg Leu 
    130                 135                 140                 


Leu Asp Leu Glu Leu Thr Ser Arg Phe Leu Gly Ala Thr Thr Asp Thr 
145                 150                 155                 160 


Thr Val Leu Glu Ala Asn Ala Val Leu Leu Gly Ile Gln Glu Ser Lys 
                165                 170                 175     


Asp Ser Arg Ser Lys Glu Glu His His Glu Lys 
            180                 185         


<210>  8947
<211>  109
<212>  PRT
<213>  Homo Sapiens

<400>  8947

Met Leu Pro Arg Leu Val Leu Asn Ser Trp Val Gln Val Ile Leu Leu 
1               5                   10                  15      


Arg Trp Pro Pro Lys Val Leu Gly Leu Gln Met Thr Asp Met Gly Pro 
            20                  25                  30          


Ala Lys Asp Lys Leu Val Ile Gly Arg Ile Phe His Ile Val Glu Asn 
        35                  40                  45              


Asp Leu Tyr Ile Asp Phe Gly Gly Lys Phe His Cys Val Cys Arg Arg 
    50                  55                  60                  


Pro Glu Val Asp Gly Glu Lys Tyr Gln Lys Gly Thr Arg Val Arg Leu 
65                  70                  75                  80  


Arg Leu Leu Asp Leu Glu Leu Thr Ser Arg Phe Leu Gly Ala Thr Thr 
                85                  90                  95      


Asp Thr Thr Val Leu Glu Ala Asn Ala Val Leu Leu Gly 
            100                 105                 


<210>  8948
<211>  125
<212>  PRT
<213>  Homo Sapiens

<400>  8948

Met Leu Pro Arg Leu Val Leu Asn Ser Trp Val Gln Val Ile Leu Leu 
1               5                   10                  15      


Arg Trp Pro Pro Lys Val Leu Gly Leu Gln Met Thr Asp Met Gly Pro 
            20                  25                  30          


Ala Lys Asp Lys Leu Val Ile Gly Arg Ile Phe His Ile Val Glu Asn 
        35                  40                  45              


Asp Leu Tyr Ile Asp Phe Gly Gly Lys Phe His Cys Val Cys Arg Arg 
    50                  55                  60                  


Pro Glu Val Asp Gly Glu Lys Tyr Gln Lys Gly Thr Arg Val Arg Leu 
65                  70                  75                  80  


Arg Leu Leu Asp Leu Glu Leu Thr Ser Arg Phe Leu Gly Ala Thr Thr 
                85                  90                  95      


Asp Thr Thr Val Leu Glu Ala Asn Ala Val Leu Leu Gly Ile Gln Glu 
            100                 105                 110         


Ser Lys Asp Ser Arg Ser Lys Glu Glu His His Glu Lys 
        115                 120                 125 


<210>  8949
<211>  103
<212>  PRT
<213>  Homo Sapiens

<400>  8949

Met Leu Arg His Ser Pro Leu Thr Gln Met Gly Pro Ala Lys Asp Lys 
1               5                   10                  15      


Leu Val Ile Gly Arg Ile Phe His Ile Val Glu Asn Asp Leu Tyr Ile 
            20                  25                  30          


Asp Phe Gly Gly Lys Phe His Cys Val Cys Arg Arg Pro Glu Val Asp 
        35                  40                  45              


Gly Glu Lys Tyr Gln Lys Gly Thr Arg Val Arg Leu Arg Leu Leu Asp 
    50                  55                  60                  


Leu Glu Leu Thr Ser Arg Phe Leu Gly Ala Thr Thr Asp Thr Thr Val 
65                  70                  75                  80  


Leu Glu Ala Asn Ala Val Leu Leu Gly Ile Gln Glu Ser Lys Asp Ser 
                85                  90                  95      


Arg Ser Lys Glu Glu His His 
            100             


<210>  8950
<211>  143
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8950

Xaa Phe Cys Val Ala Phe Ala Tyr Trp Ala Gly Ser Val His Thr Ala 
1               5                   10                  15      


Leu Val Phe Leu Gly Leu Asn Ala Gly Gly Lys Gly Ser Pro Lys Asn 
            20                  25                  30          


Val Glu Ser Phe Ala Ser Met Leu Arg His Ser Pro Leu Thr Gln Met 
        35                  40                  45              


Gly Pro Ala Lys Asp Lys Leu Val Ile Gly Arg Ile Phe His Ile Val 
    50                  55                  60                  


Glu Asn Asp Leu Tyr Ile Asp Phe Gly Gly Lys Phe His Cys Val Cys 
65                  70                  75                  80  


Arg Arg Pro Glu Val Asp Gly Glu Lys Tyr Gln Lys Gly Thr Arg Val 
                85                  90                  95      


Arg Leu Arg Leu Leu Asp Leu Glu Leu Thr Ser Arg Phe Leu Gly Ala 
            100                 105                 110         


Thr Thr Asp Thr Thr Val Leu Glu Ala Asn Ala Val Leu Leu Gly Ile 
        115                 120                 125             


Gln Glu Ser Lys Asp Ser Arg Ser Lys Glu Glu His His Glu Lys 
    130                 135                 140             


<210>  8951
<211>  83
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8951

Xaa Met Leu Arg His Ser Pro Leu Thr Gln Met Gly Pro Ala Lys Asp 
1               5                   10                  15      


Lys Leu Val Ile Gly Arg Ile Phe His Ile Val Glu Asn Asp Leu Tyr 
            20                  25                  30          


Ile Asp Phe Gly Gly Lys Phe His Cys Val Cys Arg Arg Pro Glu Val 
        35                  40                  45              


Asp Gly Glu Ser Pro Ile Ser Trp Tyr Ala Val Trp Arg Arg Phe Ser 
    50                  55                  60                  


Gln Val Met Ile Thr Cys Phe Ser Ser Asn Ser Asp Phe Gly Lys His 
65                  70                  75                  80  


Arg Lys Arg 
            


<210>  8952
<211>  163
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8952

Xaa Thr Arg Ala Val Ala Ala Glu Ser His Phe Leu Arg Val Phe Leu 
1               5                   10                  15      


Phe Phe Arg Pro Phe Arg Gly Val Gly Thr Glu Ser Gly Ser Glu Ser 
            20                  25                  30          


Gly Ser Ser Asn Ala Lys Glu Pro Lys Thr Arg Ala Gly Gly Phe Ala 
        35                  40                  45              


Ser Ala Leu Glu Arg His Ser Glu Leu Leu Gln Lys Arg Trp Gly Phe 
    50                  55                  60                  


Ala Met Leu Pro Arg Leu Val Leu Asn Ser Trp Val Gln Val Ile Leu 
65                  70                  75                  80  


Leu Arg Trp Pro Pro Lys Val Leu Gly Leu Gln Met Thr Asp Gly Ser 
                85                  90                  95      


Pro Lys Asn Val Glu Ser Phe Ala Ser Met Leu Arg His Ser Pro Leu 
            100                 105                 110         


Thr Gln Met Gly Pro Ala Lys Asp Lys Leu Val Ile Gly Arg Ile Phe 
        115                 120                 125             


His Ile Val Glu Asn Asp Leu Tyr Ile Asp Phe Gly Gly Lys Phe His 
    130                 135                 140                 


Cys Val Cys Arg Arg Pro Glu Val Asp Gly Glu Lys Tyr Gln Lys Gly 
145                 150                 155                 160 


Thr Arg Val 
            


<210>  8953
<211>  170
<212>  PRT
<213>  Homo Sapiens

<400>  8953

Met Glu Ser Thr Ser Gln Asp Arg Arg Ala Thr His Val Ile Thr Ile 
1               5                   10                  15      


Lys Pro Asn Glu Thr Val Leu Thr Ala Phe Pro Tyr Arg Pro His Ser 
            20                  25                  30          


Ser Leu Leu Asp Phe Leu Lys Gly Glu Pro Arg Val Leu Gly Ala Thr 
        35                  40                  45              


Gln Ile Leu Leu Ala Leu Ile Ile Val Gly Phe Gly Thr Ile Phe Ala 
    50                  55                  60                  


Leu Asn Tyr Ile Gly Phe Ser Gln Arg Leu Pro Leu Val Val Leu Thr 
65                  70                  75                  80  


Gly Tyr Pro Phe Trp Gly Ala Leu Ile Phe Ile Leu Thr Gly Tyr Leu 
                85                  90                  95      


Thr Val Thr Asp Lys Lys Ser Lys Leu Leu Gly Gln Gly Val Thr Gly 
            100                 105                 110         


Met Asn Val Ile Ser Ser Leu Val Ala Ile Thr Gly Ile Thr Phe Thr 
        115                 120                 125             


Ile Leu Ser Tyr Arg His Gln Asp Lys Tyr Cys Gln Met Pro Ser Phe 
    130                 135                 140                 


Glu Glu Ile Cys Val Phe Ser Arg Thr Leu Phe Ile Asp Phe Ile Leu 
145                 150                 155                 160 


Leu Thr Pro Pro His Ser Ser His Phe Leu 
                165                 170 


<210>  8954
<211>  712
<212>  PRT
<213>  Homo Sapiens

<400>  8954

Met Glu Ser Thr Ser Gln Asp Arg Arg Ala Thr His Val Ile Thr Ile 
1               5                   10                  15      


Lys Pro Asn Glu Thr Val Leu Thr Ala Phe Pro Tyr Arg Pro His Ser 
            20                  25                  30          


Ser Leu Leu Asp Phe Leu Lys Gly Glu Pro Arg Val Leu Gly Ala Thr 
        35                  40                  45              


Gln Ile Leu Leu Ala Leu Ile Ile Val Gly Phe Gly Thr Ile Phe Ala 
    50                  55                  60                  


Leu Asn Tyr Ile Gly Phe Ser Gln Arg Leu Pro Leu Val Val Leu Thr 
65                  70                  75                  80  


Gly Tyr Pro Phe Trp Gly Ala Leu Ile Phe Ile Leu Thr Gly Tyr Leu 
                85                  90                  95      


Thr Val Thr Asp Lys Lys Ser Lys Leu Leu Gly Gln Gly Val Thr Gly 
            100                 105                 110         


Met Asn Val Ile Ser Ser Leu Val Ala Ile Thr Gly Ile Thr Phe Thr 
        115                 120                 125             


Ile Leu Ser Tyr Arg His Gln Asp Lys Tyr Cys Gln Met Pro Ser Phe 
    130                 135                 140                 


Glu Glu Ile Cys Val Phe Ser Arg Thr Leu Phe Ile Gly Ile Leu Leu 
145                 150                 155                 160 


Ile Leu Leu Ile Ile Ser Ile Ala Glu Leu Ser Ile Ser Val Thr Ile 
                165                 170                 175     


Ala Ser Phe Arg Ser Lys Cys Trp Thr Gln Ser Asp Glu Val Leu Phe 
            180                 185                 190         


Phe Leu Pro Ser Asp Val Thr Gln Asn Ser Glu Gln Pro Ala Pro Glu 
        195                 200                 205             


Glu Asn Asp Gln Leu Gln Phe Val Leu Gln Glu Glu Phe Ser Ser Asp 
    210                 215                 220                 


Asp Ser Thr Thr Asn Ala Gln Ser Val Ile Phe Gly Gly Tyr Ala Phe 
225                 230                 235                 240 


Phe Lys Leu Thr Leu Ser Arg Ser Pro Leu Val Ser Gln Pro Gly Asn 
                245                 250                 255     


Lys Gly Arg Glu Phe Val Pro Asp Glu Gln Lys Gln Ser Ile Leu Pro 
            260                 265                 270         


Ser Pro Lys Phe Ser Glu Glu Glu Ile Glu Pro Leu Pro Pro Thr Leu 
        275                 280                 285             


Glu Lys Lys Pro Ser Glu Asn Met Ser Ile Gln Leu Asp Ser Thr Phe 
    290                 295                 300                 


Lys Gln Met Lys Asp Glu Asp Leu Gln Ser Ala Ile Val Gln Pro Ser 
305                 310                 315                 320 


Gln Met Gln Thr Lys Leu Leu Gln Asp Gln Ala Ala Ser Leu Gln Val 
                325                 330                 335     


Phe Pro Ser His Ser Ala Leu Lys Leu Glu Asp Ile Ser Pro Glu Asp 
            340                 345                 350         


Leu Pro Ser Gln Ala Leu Pro Val Glu Gly Leu Ser Glu Gln Thr Met 
        355                 360                 365             


Pro Ser Lys Ser Thr Ser Ser His Val Lys Gln Ser Ser Asn Leu Thr 
    370                 375                 380                 


Ala Asn Asp Leu Pro Pro Gln Gly Ile Leu Ser Gln Asp Thr Ser Ser 
385                 390                 395                 400 


Gln Asp Met Leu Phe His Asp Met Thr Ser Gln Asp Met Gln Ser Leu 
                405                 410                 415     


Asp Met Leu Ser Gln Asp Thr Pro Ser His Ala Met Pro Pro Gln Asp 
            420                 425                 430         


Ile Pro Ser Gln Asp Met Leu Ser Gln Ala Leu Ser Ala His Ala Ile 
        435                 440                 445             


Leu Pro Glu Ala Ser Thr Ser His Ile Val Gln Phe Pro Glu Ile Gln 
    450                 455                 460                 


His Leu Leu Gln Gln Pro Pro Asp Leu Gln Pro Glu Asn Thr Glu Pro 
465                 470                 475                 480 


Gln Asn Gln Gln Ile Leu Gln Met Ser Tyr Gln Asp Ile Arg Ser Glu 
                485                 490                 495     


Val Met Glu Glu Thr Lys Glu Trp Lys Ser Glu Glu Glu Leu His Arg 
            500                 505                 510         


Arg Lys Ser Ser Arg Arg His Ser Leu Asn Gln Gln Thr Lys Ala Leu 
        515                 520                 525             


Gln Tyr Leu Arg Arg His Ser Leu Asp Val Gln Ala Lys Gly Gln Lys 
    530                 535                 540                 


Ser Ser Lys Arg His Ser Leu Asp Gln Gln Ser Lys Gly Trp Gln Ser 
545                 550                 555                 560 


Pro Lys Gln Lys Ser Leu Asp Gln Gln Ile Lys Asp Trp Leu Ser Pro 
                565                 570                 575     


Lys Arg His Ser Val Asp Lys Gln Ala Gln Leu Asn Gln Thr Lys Glu 
            580                 585                 590         


Gln Leu Pro Asp Gln Gln Ala Glu Asp Gln Gln Ala Lys Gly Glu Gln 
        595                 600                 605             


Tyr Pro Glu Gly Gln Ser Lys Asp Gly Gln Val Lys Asp Gln Gln Thr 
    610                 615                 620                 


Asp Lys Glu Gln Asn Ser Lys Lys Gln Thr Gln Asp Gln Gln Thr Glu 
625                 630                 635                 640 


Asp Gln Pro Ala Gln Glu Lys Lys Ser Pro Lys Gly Gln Phe Gln Asn 
                645                 650                 655     


Val Gln Ala Glu Gly Gln Gln Ala Gln Val Glu Lys Val Pro Lys Leu 
            660                 665                 670         


Leu Cys Gln Asp Ser Glu Ser Gln Ile Gln Gln Tyr Gln Phe Trp Gln 
        675                 680                 685             


Phe His Lys Gly Asn Leu Gln Ala Gly Gln Pro Arg Thr Val Asn Leu 
    690                 695                 700                 


Leu Ala Lys Asn Pro Leu Thr Gly 
705                 710         


<210>  8955
<211>  679
<212>  PRT
<213>  Homo Sapiens

<400>  8955

Met Glu Ser Thr Ser Gln Asp Arg Arg Ala Thr His Val Ile Thr Ile 
1               5                   10                  15      


Lys Pro Asn Glu Thr Val Leu Thr Ala Phe Pro Tyr Arg Pro His Ser 
            20                  25                  30          


Ser Leu Leu Asp Phe Leu Lys Gly Glu Pro Arg Val Leu Gly Ala Thr 
        35                  40                  45              


Gln Ile Leu Leu Ala Leu Ile Ile Val Gly Phe Gly Thr Ile Phe Ala 
    50                  55                  60                  


Leu Asn Tyr Ile Gly Phe Ser Gln Arg Leu Pro Leu Val Val Leu Thr 
65                  70                  75                  80  


Gly Tyr Pro Phe Trp Gly Ala Leu Ile Phe Ile Leu Thr Gly Tyr Leu 
                85                  90                  95      


Thr Val Thr Asp Lys Lys Ser Lys Leu Leu Gly Gln Gly Val Thr Gly 
            100                 105                 110         


Met Asn Val Ile Ser Ser Leu Val Ala Ile Thr Gly Ile Thr Phe Thr 
        115                 120                 125             


Ile Leu Ser Tyr Arg His Gln Asp Lys Tyr Cys Gln Met Pro Ser Phe 
    130                 135                 140                 


Glu Glu Ile Cys Val Phe Ser Arg Thr Leu Phe Ile Val Leu Phe Phe 
145                 150                 155                 160 


Leu Pro Ser Asp Val Thr Gln Asn Ser Glu Gln Pro Ala Pro Glu Glu 
                165                 170                 175     


Asn Asp Gln Leu Gln Phe Val Leu Gln Glu Glu Phe Ser Ser Asp Asp 
            180                 185                 190         


Ser Thr Thr Asn Ala Gln Ser Val Ile Phe Gly Gly Tyr Ala Phe Phe 
        195                 200                 205             


Lys Leu Thr Leu Ser Arg Ser Pro Leu Val Ser Gln Pro Gly Asn Lys 
    210                 215                 220                 


Gly Arg Glu Phe Val Pro Asp Glu Gln Lys Gln Ser Ile Leu Pro Ser 
225                 230                 235                 240 


Pro Lys Phe Ser Glu Glu Glu Ile Glu Pro Leu Pro Pro Thr Leu Glu 
                245                 250                 255     


Lys Lys Pro Ser Glu Asn Met Ser Ile Gln Leu Asp Ser Thr Phe Lys 
            260                 265                 270         


Gln Met Lys Asp Glu Asp Leu Gln Ser Ala Ile Val Gln Pro Ser Gln 
        275                 280                 285             


Met Gln Thr Lys Leu Leu Gln Asp Gln Ala Ala Ser Leu Gln Val Phe 
    290                 295                 300                 


Pro Ser His Ser Ala Leu Lys Leu Glu Asp Ile Ser Pro Glu Asp Leu 
305                 310                 315                 320 


Pro Ser Gln Ala Leu Pro Val Glu Gly Leu Ser Glu Gln Thr Met Pro 
                325                 330                 335     


Ser Lys Ser Thr Ser Ser His Val Lys Gln Ser Ser Asn Leu Thr Ala 
            340                 345                 350         


Asn Asp Leu Pro Pro Gln Gly Ile Leu Ser Gln Asp Thr Ser Ser Gln 
        355                 360                 365             


Asp Met Leu Phe His Asp Met Thr Ser Gln Asp Met Gln Ser Leu Asp 
    370                 375                 380                 


Met Leu Ser Gln Asp Thr Pro Ser His Ala Met Pro Pro Gln Asp Ile 
385                 390                 395                 400 


Pro Ser Gln Asp Met Leu Ser Gln Ala Leu Ser Ala His Ala Ile Leu 
                405                 410                 415     


Pro Glu Ala Ser Thr Ser His Ile Val Gln Phe Pro Glu Ile Gln His 
            420                 425                 430         


Leu Leu Gln Gln Pro Pro Asp Leu Gln Pro Glu Asn Thr Glu Pro Gln 
        435                 440                 445             


Asn Gln Gln Ile Leu Gln Met Ser Tyr Gln Asp Ile Arg Ser Glu Val 
    450                 455                 460                 


Met Glu Glu Thr Lys Glu Trp Lys Ser Glu Glu Glu Leu His Arg Arg 
465                 470                 475                 480 


Lys Ser Ser Arg Arg His Ser Leu Asn Gln Gln Thr Lys Ala Leu Gln 
                485                 490                 495     


Tyr Leu Arg Arg His Ser Leu Asp Val Gln Ala Lys Gly Gln Lys Ser 
            500                 505                 510         


Ser Lys Arg His Ser Leu Asp Gln Gln Ser Lys Gly Trp Gln Ser Pro 
        515                 520                 525             


Lys Gln Lys Ser Leu Asp Gln Gln Ile Lys Asp Trp Leu Ser Pro Lys 
    530                 535                 540                 


Arg His Ser Val Asp Lys Gln Ala Gln Leu Asn Gln Thr Lys Glu Gln 
545                 550                 555                 560 


Leu Pro Asp Gln Gln Ala Glu Asp Gln Gln Ala Lys Gly Glu Gln Tyr 
                565                 570                 575     


Pro Glu Gly Gln Ser Lys Asp Gly Gln Val Lys Asp Gln Gln Thr Asp 
            580                 585                 590         


Lys Glu Gln Asn Ser Lys Lys Gln Thr Gln Asp Gln Gln Thr Glu Asp 
        595                 600                 605             


Gln Pro Ala Gln Glu Lys Lys Ser Pro Lys Gly Gln Phe Gln Asn Val 
    610                 615                 620                 


Gln Ala Glu Gly Gln Gln Ala Gln Val Glu Lys Val Pro Lys Leu Leu 
625                 630                 635                 640 


Cys Gln Asp Ser Glu Ser Gln Ile Gln Gln Tyr Gln Phe Trp Gln Phe 
                645                 650                 655     


His Lys Gly Asn Leu Gln Ala Gly Gln Pro Arg Thr Val Asn Leu Leu 
            660                 665                 670         


Ala Lys Asn Pro Leu Thr Gly 
        675                 


<210>  8956
<211>  153
<212>  PRT
<213>  Homo Sapiens

<400>  8956

Met Glu Ser Thr Ser Gln Asp Arg Arg Ala Thr His Val Ile Thr Ile 
1               5                   10                  15      


Lys Pro Asn Glu Thr Val Leu Thr Ala Phe Pro Tyr Arg Pro His Ser 
            20                  25                  30          


Ser Leu Leu Asp Phe Leu Lys Gly Glu Pro Arg Val Leu Gly Ala Thr 
        35                  40                  45              


Gln Ile Leu Leu Ala Leu Ile Ile Val Gly Phe Gly Thr Ile Phe Ala 
    50                  55                  60                  


Leu Asn Tyr Ile Gly Phe Ser Gln Arg Leu Pro Leu Val Val Leu Thr 
65                  70                  75                  80  


Gly Tyr Pro Phe Trp Gly Ala Leu Ile Gly Gln Gly Val Thr Gly Met 
                85                  90                  95      


Asn Val Ile Ser Ser Leu Val Ala Ile Thr Gly Ile Thr Phe Thr Ile 
            100                 105                 110         


Leu Ser Tyr Arg His Gln Asp Lys Tyr Cys Gln Met Pro Ser Phe Glu 
        115                 120                 125             


Glu Ile Cys Val Phe Ser Arg Thr Leu Phe Ile Asp Phe Ile Leu Leu 
    130                 135                 140                 


Thr Pro Pro His Ser Ser His Phe Leu 
145                 150             


<210>  8957
<211>  153
<212>  PRT
<213>  Homo Sapiens

<400>  8957

Met Glu Ser Thr Ser Gln Asp Arg Arg Ala Thr His Val Ile Thr Ile 
1               5                   10                  15      


Lys Pro Asn Glu Thr Val Leu Thr Ala Phe Pro Tyr Arg Pro His Ser 
            20                  25                  30          


Ser Leu Leu Asp Phe Leu Lys Gly Glu Pro Arg Val Leu Gly Ala Thr 
        35                  40                  45              


Gln Ile Leu Leu Ala Leu Ile Ile Val Gly Phe Gly Thr Ile Phe Ala 
    50                  55                  60                  


Leu Asn Tyr Ile Gly Phe Ser Gln Arg Leu Pro Leu Val Val Leu Thr 
65                  70                  75                  80  


Gly Tyr Pro Phe Trp Gly Ala Leu Ile Gly Gln Gly Val Thr Gly Met 
                85                  90                  95      


Asn Val Ile Ser Ser Leu Val Ala Ile Thr Gly Ile Thr Phe Thr Ile 
            100                 105                 110         


Leu Ser Tyr Arg His Gln Asp Lys Tyr Cys Gln Met Pro Ser Phe Glu 
        115                 120                 125             


Glu Ile Cys Val Phe Ser Arg Thr Leu Phe Ile Asp Phe Ile Leu Leu 
    130                 135                 140                 


Thr Pro Pro His Ser Ser His Phe Leu 
145                 150             


<210>  8958
<211>  148
<212>  PRT
<213>  Homo Sapiens

<400>  8958

Met Glu Ser Thr Ser Gln Asp Arg Arg Ala Thr His Val Ile Thr Ile 
1               5                   10                  15      


Lys Pro Asn Glu Thr Val Leu Thr Ala Phe Pro Tyr Arg Pro His Ser 
            20                  25                  30          


Ser Leu Leu Asp Phe Leu Lys Gly Glu Pro Arg Val Leu Gly Ala Thr 
        35                  40                  45              


Gln Ile Leu Leu Ala Leu Ile Ile Val Gly Phe Gly Thr Ile Phe Ala 
    50                  55                  60                  


Leu Asn Tyr Ile Gly Phe Ser Gln Arg Leu Pro Leu Val Val Leu Thr 
65                  70                  75                  80  


Gly Tyr Pro Phe Trp Gly Ala Leu Ile Gly Gln Gly Val Thr Gly Met 
                85                  90                  95      


Asn Val Ile Ser Ser Leu Val Ala Ile Thr Gly Ile Thr Phe Thr Ile 
            100                 105                 110         


Leu Ser Tyr Arg His Gln Asp Lys Tyr Cys Gln Met Pro Ser Phe Glu 
        115                 120                 125             


Glu Ile Cys Val Phe Ser Arg Thr Leu Phe Ile Gly Ile Leu Leu Ile 
    130                 135                 140                 


Leu Leu Ile Ile 
145             


<210>  8959
<211>  695
<212>  PRT
<213>  Homo Sapiens

<400>  8959

Met Glu Ser Thr Ser Gln Asp Arg Arg Ala Thr His Val Ile Thr Ile 
1               5                   10                  15      


Lys Pro Asn Glu Thr Val Leu Thr Ala Phe Pro Tyr Arg Pro His Ser 
            20                  25                  30          


Ser Leu Leu Asp Phe Leu Lys Gly Glu Pro Arg Val Leu Gly Ala Thr 
        35                  40                  45              


Gln Ile Leu Leu Ala Leu Ile Ile Val Gly Phe Gly Thr Ile Phe Ala 
    50                  55                  60                  


Leu Asn Tyr Ile Gly Phe Ser Gln Arg Leu Pro Leu Val Val Leu Thr 
65                  70                  75                  80  


Gly Tyr Pro Phe Trp Gly Ala Leu Ile Gly Gln Gly Val Thr Gly Met 
                85                  90                  95      


Asn Val Ile Ser Ser Leu Val Ala Ile Thr Gly Ile Thr Phe Thr Ile 
            100                 105                 110         


Leu Ser Tyr Arg His Gln Asp Lys Tyr Cys Gln Met Pro Ser Phe Glu 
        115                 120                 125             


Glu Ile Cys Val Phe Ser Arg Thr Leu Phe Ile Gly Ile Leu Leu Ile 
    130                 135                 140                 


Leu Leu Ile Ile Ser Ile Ala Glu Leu Ser Ile Ser Val Thr Ile Ala 
145                 150                 155                 160 


Ser Phe Arg Ser Lys Cys Trp Thr Gln Ser Asp Glu Val Leu Phe Phe 
                165                 170                 175     


Leu Pro Ser Asp Val Thr Gln Asn Ser Glu Gln Pro Ala Pro Glu Glu 
            180                 185                 190         


Asn Asp Gln Leu Gln Phe Val Leu Gln Glu Glu Phe Ser Ser Asp Asp 
        195                 200                 205             


Ser Thr Thr Asn Ala Gln Ser Val Ile Phe Gly Gly Tyr Ala Phe Phe 
    210                 215                 220                 


Lys Leu Thr Leu Ser Arg Ser Pro Leu Val Ser Gln Pro Gly Asn Lys 
225                 230                 235                 240 


Gly Arg Glu Phe Val Pro Asp Glu Gln Lys Gln Ser Ile Leu Pro Ser 
                245                 250                 255     


Pro Lys Phe Ser Glu Glu Glu Ile Glu Pro Leu Pro Pro Thr Leu Glu 
            260                 265                 270         


Lys Lys Pro Ser Glu Asn Met Ser Ile Gln Leu Asp Ser Thr Phe Lys 
        275                 280                 285             


Gln Met Lys Asp Glu Asp Leu Gln Ser Ala Ile Val Gln Pro Ser Gln 
    290                 295                 300                 


Met Gln Thr Lys Leu Leu Gln Asp Gln Ala Ala Ser Leu Gln Val Phe 
305                 310                 315                 320 


Pro Ser His Ser Ala Leu Lys Leu Glu Asp Ile Ser Pro Glu Asp Leu 
                325                 330                 335     


Pro Ser Gln Ala Leu Pro Val Glu Gly Leu Ser Glu Gln Thr Met Pro 
            340                 345                 350         


Ser Lys Ser Thr Ser Ser His Val Lys Gln Ser Ser Asn Leu Thr Ala 
        355                 360                 365             


Asn Asp Leu Pro Pro Gln Gly Ile Leu Ser Gln Asp Thr Ser Ser Gln 
    370                 375                 380                 


Asp Met Leu Phe His Asp Met Thr Ser Gln Asp Met Gln Ser Leu Asp 
385                 390                 395                 400 


Met Leu Ser Gln Asp Thr Pro Ser His Ala Met Pro Pro Gln Asp Ile 
                405                 410                 415     


Pro Ser Gln Asp Met Leu Ser Gln Ala Leu Ser Ala His Ala Ile Leu 
            420                 425                 430         


Pro Glu Ala Ser Thr Ser His Ile Val Gln Phe Pro Glu Ile Gln His 
        435                 440                 445             


Leu Leu Gln Gln Pro Pro Asp Leu Gln Pro Glu Asn Thr Glu Pro Gln 
    450                 455                 460                 


Asn Gln Gln Ile Leu Gln Met Ser Tyr Gln Asp Ile Arg Ser Glu Val 
465                 470                 475                 480 


Met Glu Glu Thr Lys Glu Trp Lys Ser Glu Glu Glu Leu His Arg Arg 
                485                 490                 495     


Lys Ser Ser Arg Arg His Ser Leu Asn Gln Gln Thr Lys Ala Leu Gln 
            500                 505                 510         


Tyr Leu Arg Arg His Ser Leu Asp Val Gln Ala Lys Gly Gln Lys Ser 
        515                 520                 525             


Ser Lys Arg His Ser Leu Asp Gln Gln Ser Lys Gly Trp Gln Ser Pro 
    530                 535                 540                 


Lys Gln Lys Ser Leu Asp Gln Gln Ile Lys Asp Trp Leu Ser Pro Lys 
545                 550                 555                 560 


Arg His Ser Val Asp Lys Gln Ala Gln Leu Asn Gln Thr Lys Glu Gln 
                565                 570                 575     


Leu Pro Asp Gln Gln Ala Glu Asp Gln Gln Ala Lys Gly Glu Gln Tyr 
            580                 585                 590         


Pro Glu Gly Gln Ser Lys Asp Gly Gln Val Lys Asp Gln Gln Thr Asp 
        595                 600                 605             


Lys Glu Gln Asn Ser Lys Lys Gln Thr Gln Asp Gln Gln Thr Glu Asp 
    610                 615                 620                 


Gln Pro Ala Gln Glu Lys Lys Ser Pro Lys Gly Gln Phe Gln Asn Val 
625                 630                 635                 640 


Gln Ala Glu Gly Gln Gln Ala Gln Val Glu Lys Val Pro Lys Leu Leu 
                645                 650                 655     


Cys Gln Asp Ser Glu Ser Gln Ile Gln Gln Tyr Gln Phe Trp Gln Phe 
            660                 665                 670         


His Lys Gly Asn Leu Gln Ala Gly Gln Pro Arg Thr Val Asn Leu Leu 
        675                 680                 685             


Ala Lys Asn Pro Leu Thr Gly 
    690                 695 


<210>  8960
<211>  662
<212>  PRT
<213>  Homo Sapiens

<400>  8960

Met Glu Ser Thr Ser Gln Asp Arg Arg Ala Thr His Val Ile Thr Ile 
1               5                   10                  15      


Lys Pro Asn Glu Thr Val Leu Thr Ala Phe Pro Tyr Arg Pro His Ser 
            20                  25                  30          


Ser Leu Leu Asp Phe Leu Lys Gly Glu Pro Arg Val Leu Gly Ala Thr 
        35                  40                  45              


Gln Ile Leu Leu Ala Leu Ile Ile Val Gly Phe Gly Thr Ile Phe Ala 
    50                  55                  60                  


Leu Asn Tyr Ile Gly Phe Ser Gln Arg Leu Pro Leu Val Val Leu Thr 
65                  70                  75                  80  


Gly Tyr Pro Phe Trp Gly Ala Leu Ile Gly Gln Gly Val Thr Gly Met 
                85                  90                  95      


Asn Val Ile Ser Ser Leu Val Ala Ile Thr Gly Ile Thr Phe Thr Ile 
            100                 105                 110         


Leu Ser Tyr Arg His Gln Asp Lys Tyr Cys Gln Met Pro Ser Phe Glu 
        115                 120                 125             


Glu Ile Cys Val Phe Ser Arg Thr Leu Phe Ile Val Leu Phe Phe Leu 
    130                 135                 140                 


Pro Ser Asp Val Thr Gln Asn Ser Glu Gln Pro Ala Pro Glu Glu Asn 
145                 150                 155                 160 


Asp Gln Leu Gln Phe Val Leu Gln Glu Glu Phe Ser Ser Asp Asp Ser 
                165                 170                 175     


Thr Thr Asn Ala Gln Ser Val Ile Phe Gly Gly Tyr Ala Phe Phe Lys 
            180                 185                 190         


Leu Thr Leu Ser Arg Ser Pro Leu Val Ser Gln Pro Gly Asn Lys Gly 
        195                 200                 205             


Arg Glu Phe Val Pro Asp Glu Gln Lys Gln Ser Ile Leu Pro Ser Pro 
    210                 215                 220                 


Lys Phe Ser Glu Glu Glu Ile Glu Pro Leu Pro Pro Thr Leu Glu Lys 
225                 230                 235                 240 


Lys Pro Ser Glu Asn Met Ser Ile Gln Leu Asp Ser Thr Phe Lys Gln 
                245                 250                 255     


Met Lys Asp Glu Asp Leu Gln Ser Ala Ile Val Gln Pro Ser Gln Met 
            260                 265                 270         


Gln Thr Lys Leu Leu Gln Asp Gln Ala Ala Ser Leu Gln Val Phe Pro 
        275                 280                 285             


Ser His Ser Ala Leu Lys Leu Glu Asp Ile Ser Pro Glu Asp Leu Pro 
    290                 295                 300                 


Ser Gln Ala Leu Pro Val Glu Gly Leu Ser Glu Gln Thr Met Pro Ser 
305                 310                 315                 320 


Lys Ser Thr Ser Ser His Val Lys Gln Ser Ser Asn Leu Thr Ala Asn 
                325                 330                 335     


Asp Leu Pro Pro Gln Gly Ile Leu Ser Gln Asp Thr Ser Ser Gln Asp 
            340                 345                 350         


Met Leu Phe His Asp Met Thr Ser Gln Asp Met Gln Ser Leu Asp Met 
        355                 360                 365             


Leu Ser Gln Asp Thr Pro Ser His Ala Met Pro Pro Gln Asp Ile Pro 
    370                 375                 380                 


Ser Gln Asp Met Leu Ser Gln Ala Leu Ser Ala His Ala Ile Leu Pro 
385                 390                 395                 400 


Glu Ala Ser Thr Ser His Ile Val Gln Phe Pro Glu Ile Gln His Leu 
                405                 410                 415     


Leu Gln Gln Pro Pro Asp Leu Gln Pro Glu Asn Thr Glu Pro Gln Asn 
            420                 425                 430         


Gln Gln Ile Leu Gln Met Ser Tyr Gln Asp Ile Arg Ser Glu Val Met 
        435                 440                 445             


Glu Glu Thr Lys Glu Trp Lys Ser Glu Glu Glu Leu His Arg Arg Lys 
    450                 455                 460                 


Ser Ser Arg Arg His Ser Leu Asn Gln Gln Thr Lys Ala Leu Gln Tyr 
465                 470                 475                 480 


Leu Arg Arg His Ser Leu Asp Val Gln Ala Lys Gly Gln Lys Ser Ser 
                485                 490                 495     


Lys Arg His Ser Leu Asp Gln Gln Ser Lys Gly Trp Gln Ser Pro Lys 
            500                 505                 510         


Gln Lys Ser Leu Asp Gln Gln Ile Lys Asp Trp Leu Ser Pro Lys Arg 
        515                 520                 525             


His Ser Val Asp Lys Gln Ala Gln Leu Asn Gln Thr Lys Glu Gln Leu 
    530                 535                 540                 


Pro Asp Gln Gln Ala Glu Asp Gln Gln Ala Lys Gly Glu Gln Tyr Pro 
545                 550                 555                 560 


Glu Gly Gln Ser Lys Asp Gly Gln Val Lys Asp Gln Gln Thr Asp Lys 
                565                 570                 575     


Glu Gln Asn Ser Lys Lys Gln Thr Gln Asp Gln Gln Thr Glu Asp Gln 
            580                 585                 590         


Pro Ala Gln Glu Lys Lys Ser Pro Lys Gly Gln Phe Gln Asn Val Gln 
        595                 600                 605             


Ala Glu Gly Gln Gln Ala Gln Val Glu Lys Val Pro Lys Leu Leu Cys 
    610                 615                 620                 


Gln Asp Ser Glu Ser Gln Ile Gln Gln Tyr Gln Phe Trp Gln Phe His 
625                 630                 635                 640 


Lys Gly Asn Leu Gln Ala Gly Gln Pro Arg Thr Val Asn Leu Leu Ala 
                645                 650                 655     


Lys Asn Pro Leu Thr Gly 
            660         


<210>  8961
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  8961

Met Glu Ser Thr Ser Gln Asp Arg Arg Ala Thr His Val Ile Thr Ile 
1               5                   10                  15      


Lys Pro Asn Glu Thr Val Leu Thr Ala Phe Pro Tyr Arg Pro His Ser 
            20                  25                  30          


Ser Leu Leu Asp Phe Leu Lys Gly Glu Pro Arg Val Leu Gly Ala Thr 
        35                  40                  45              


Gln Ile Leu Leu Ala Leu Ile Ile Val Gly Phe Gly Thr Ile Phe Ala 
    50                  55                  60                  


Leu Asn Tyr Ile Gly Phe Ser Gln Arg Leu Pro Leu Val Val Leu Thr 
65                  70                  75                  80  


Gly Tyr Pro Phe Trp Gly Ala Leu Ile Val Ser Thr Val Asp 
                85                  90                  


<210>  8962
<211>  567
<212>  PRT
<213>  Homo Sapiens

<400>  8962

Met Asn Val Ile Ser Ser Leu Val Ala Ile Thr Gly Ile Thr Phe Thr 
1               5                   10                  15      


Ile Leu Ser Tyr Arg His Gln Asp Lys Tyr Cys Gln Met Pro Ser Phe 
            20                  25                  30          


Glu Glu Ile Cys Val Phe Ser Arg Thr Leu Phe Ile Val Leu Phe Phe 
        35                  40                  45              


Leu Pro Ser Asp Val Thr Gln Asn Ser Glu Gln Pro Ala Pro Glu Glu 
    50                  55                  60                  


Asn Asp Gln Leu Gln Phe Val Leu Gln Glu Glu Phe Ser Ser Asp Asp 
65                  70                  75                  80  


Ser Thr Thr Asn Ala Gln Ser Val Ile Phe Gly Gly Tyr Ala Phe Phe 
                85                  90                  95      


Lys Leu Thr Leu Ser Arg Ser Pro Leu Val Ser Gln Pro Gly Asn Lys 
            100                 105                 110         


Gly Arg Glu Phe Val Pro Asp Glu Gln Lys Gln Ser Ile Leu Pro Ser 
        115                 120                 125             


Pro Lys Phe Ser Glu Glu Glu Ile Glu Pro Leu Pro Pro Thr Leu Glu 
    130                 135                 140                 


Lys Lys Pro Ser Glu Asn Met Ser Ile Gln Leu Asp Ser Thr Phe Lys 
145                 150                 155                 160 


Gln Met Lys Asp Glu Asp Leu Gln Ser Ala Ile Val Gln Pro Ser Gln 
                165                 170                 175     


Met Gln Thr Lys Leu Leu Gln Asp Gln Ala Ala Ser Leu Gln Val Phe 
            180                 185                 190         


Pro Ser His Ser Ala Leu Lys Leu Glu Asp Ile Ser Pro Glu Asp Leu 
        195                 200                 205             


Pro Ser Gln Ala Leu Pro Val Glu Gly Leu Ser Glu Gln Thr Met Pro 
    210                 215                 220                 


Ser Lys Ser Thr Ser Ser His Val Lys Gln Ser Ser Asn Leu Thr Ala 
225                 230                 235                 240 


Asn Asp Leu Pro Pro Gln Gly Ile Leu Ser Gln Asp Thr Ser Ser Gln 
                245                 250                 255     


Asp Met Leu Phe His Asp Met Thr Ser Gln Asp Met Gln Ser Leu Asp 
            260                 265                 270         


Met Leu Ser Gln Asp Thr Pro Ser His Ala Met Pro Pro Gln Asp Ile 
        275                 280                 285             


Pro Ser Gln Asp Met Leu Ser Gln Ala Leu Ser Ala His Ala Ile Leu 
    290                 295                 300                 


Pro Glu Ala Ser Thr Ser His Ile Val Gln Phe Pro Glu Ile Gln His 
305                 310                 315                 320 


Leu Leu Gln Gln Pro Pro Asp Leu Gln Pro Glu Asn Thr Glu Pro Gln 
                325                 330                 335     


Asn Gln Gln Ile Leu Gln Met Ser Tyr Gln Asp Ile Arg Ser Glu Val 
            340                 345                 350         


Met Glu Glu Thr Lys Glu Trp Lys Ser Glu Glu Glu Leu His Arg Arg 
        355                 360                 365             


Lys Ser Ser Arg Arg His Ser Leu Asn Gln Gln Thr Lys Ala Leu Gln 
    370                 375                 380                 


Tyr Leu Arg Arg His Ser Leu Asp Val Gln Ala Lys Gly Gln Lys Ser 
385                 390                 395                 400 


Ser Lys Arg His Ser Leu Asp Gln Gln Ser Lys Gly Trp Gln Ser Pro 
                405                 410                 415     


Lys Gln Lys Ser Leu Asp Gln Gln Ile Lys Asp Trp Leu Ser Pro Lys 
            420                 425                 430         


Arg His Ser Val Asp Lys Gln Ala Gln Leu Asn Gln Thr Lys Glu Gln 
        435                 440                 445             


Leu Pro Asp Gln Gln Ala Glu Asp Gln Gln Ala Lys Gly Glu Gln Tyr 
    450                 455                 460                 


Pro Glu Gly Gln Ser Lys Asp Gly Gln Val Lys Asp Gln Gln Thr Asp 
465                 470                 475                 480 


Lys Glu Gln Asn Ser Lys Lys Gln Thr Gln Asp Gln Gln Thr Glu Asp 
                485                 490                 495     


Gln Pro Ala Gln Glu Lys Lys Ser Pro Lys Gly Gln Phe Gln Asn Val 
            500                 505                 510         


Gln Ala Glu Gly Gln Gln Ala Gln Val Glu Lys Val Pro Lys Leu Leu 
        515                 520                 525             


Cys Gln Asp Ser Glu Ser Gln Ile Gln Gln Tyr Gln Phe Trp Gln Phe 
    530                 535                 540                 


His Lys Gly Asn Leu Gln Ala Gly Gln Pro Arg Thr Val Asn Leu Leu 
545                 550                 555                 560 


Ala Lys Asn Pro Leu Thr Gly 
                565         


<210>  8963
<211>  139
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8963

Xaa Arg Val Leu Gly Ala Thr Gln Ile Leu Leu Ala Leu Ile Ile Val 
1               5                   10                  15      


Gly Phe Gly Thr Ile Phe Ala Leu Asn Tyr Ile Gly Phe Ser Gln Arg 
            20                  25                  30          


Leu Pro Leu Val Val Leu Thr Gly Tyr Pro Phe Trp Gly Ala Leu Ile 
        35                  40                  45              


Phe Ile Leu Thr Gly Tyr Leu Thr Val Thr Asp Lys Lys Ser Lys Leu 
    50                  55                  60                  


Leu Gly Gln Gly Val Thr Gly Met Asn Val Ile Ser Ser Leu Val Ala 
65                  70                  75                  80  


Ile Thr Gly Ile Thr Phe Thr Ile Leu Ser Tyr Arg His Gln Asp Lys 
                85                  90                  95      


Tyr Cys Gln Met Pro Ser Phe Glu Glu Ile Cys Val Phe Ser Arg Thr 
            100                 105                 110         


Leu Phe Ile Val Ser Gly Leu Ile Leu His Glu Glu Ser Leu Lys Ser 
        115                 120                 125             


Ser Leu Asn Cys Val His Asp Val Met Ile His 
    130                 135                 


<210>  8964
<211>  214
<212>  PRT
<213>  Homo Sapiens

<400>  8964

Met Ala Ser His Glu Val Asp Asn Ala Glu Leu Gly Ser Ala Ser Ala 
1               5                   10                  15      


His Gly Thr Pro Gly Ser Glu Ala Gly Pro Glu Glu Leu Asn Thr Ser 
            20                  25                  30          


Val Tyr Gln Pro Ile Asp Gly Ser Pro Asp Tyr Gln Lys Ala Lys Leu 
        35                  40                  45              


Gln Val Leu Gly Ala Ile Gln Ile Leu Asn Ala Ala Met Ile Leu Ala 
    50                  55                  60                  


Leu Gly Val Phe Leu Gly Ser Leu Gln Tyr Pro Tyr His Phe Gln Lys 
65                  70                  75                  80  


His Phe Phe Phe Phe Thr Phe Tyr Thr Gly Tyr Pro Ile Trp Gly Ala 
                85                  90                  95      


Val Phe Phe Cys Ser Ser Gly Thr Leu Ser Val Val Ala Gly Ile Lys 
            100                 105                 110         


Pro Thr Arg Thr Trp Ile Gln Asn Ser Phe Gly Met Asn Ile Ala Ser 
        115                 120                 125             


Ala Thr Ile Ala Leu Val Gly Thr Ala Phe Leu Ser Leu Asn Ile Ala 
    130                 135                 140                 


Val Asn Ile Gln Ser Leu Arg Ser Cys His Ser Ser Ser Glu Ser Pro 
145                 150                 155                 160 


Asp Leu Cys Asn Tyr Met Gly Ser Ile Ser Asn Gly Met Val Ser Leu 
                165                 170                 175     


Leu Leu Ile Leu Thr Leu Leu Glu Leu Cys Val Thr Ile Ser Thr Ile 
            180                 185                 190         


Ala Met Trp Cys Asn Ala Asn Cys Cys Asn Ser Arg Glu Glu Ile Ser 
        195                 200                 205             


Ser Pro Pro Asn Ser Val 
    210                 


<210>  8965
<211>  168
<212>  PRT
<213>  Homo Sapiens

<400>  8965

Met Ala Ser His Glu Val Asp Asn Ala Glu Leu Gly Ser Ala Ser Ala 
1               5                   10                  15      


His Gly Thr Pro Gly Ser Glu Ala Gly Pro Glu Glu Leu Asn Thr Ser 
            20                  25                  30          


Val Tyr Gln Pro Ile Asp Gly Ser Pro Asp Tyr Gln Lys Ala Lys Leu 
        35                  40                  45              


Gln Val Leu Gly Phe Cys Ser Ser Gly Thr Leu Ser Val Val Ala Gly 
    50                  55                  60                  


Ile Lys Pro Thr Arg Thr Trp Ile Gln Asn Ser Phe Gly Met Asn Ile 
65                  70                  75                  80  


Ala Ser Ala Thr Ile Ala Leu Val Gly Thr Ala Phe Leu Ser Leu Asn 
                85                  90                  95      


Ile Ala Val Asn Ile Gln Ser Leu Arg Ser Cys His Ser Ser Ser Glu 
            100                 105                 110         


Ser Pro Asp Leu Cys Asn Tyr Met Gly Ser Ile Ser Asn Gly Met Val 
        115                 120                 125             


Ser Leu Leu Leu Ile Leu Thr Leu Leu Glu Leu Cys Val Thr Ile Ser 
    130                 135                 140                 


Thr Ile Ala Met Trp Cys Asn Ala Asn Cys Cys Asn Ser Arg Glu Glu 
145                 150                 155                 160 


Ile Ser Ser Pro Pro Asn Ser Val 
                165             


<210>  8966
<211>  168
<212>  PRT
<213>  Homo Sapiens

<400>  8966

Met Ala Ser His Glu Val Asp Asn Ala Glu Leu Gly Ser Ala Ser Ala 
1               5                   10                  15      


His Gly Thr Pro Gly Ser Glu Ala Gly Pro Glu Glu Leu Asn Thr Ser 
            20                  25                  30          


Val Tyr Gln Pro Ile Asp Gly Ser Pro Asp Tyr Gln Lys Ala Lys Leu 
        35                  40                  45              


Gln Val Leu Gly Phe Cys Ser Ser Gly Thr Leu Ser Val Val Ala Gly 
    50                  55                  60                  


Ile Lys Pro Thr Arg Thr Trp Ile Gln Asn Ser Phe Gly Met Asn Ile 
65                  70                  75                  80  


Ala Ser Ala Thr Ile Ala Leu Val Gly Thr Ala Phe Leu Ser Leu Asn 
                85                  90                  95      


Ile Ala Val Asn Ile Gln Ser Leu Arg Ser Cys His Ser Ser Ser Glu 
            100                 105                 110         


Ser Pro Asp Leu Cys Asn Tyr Met Gly Ser Ile Ser Asn Gly Met Val 
        115                 120                 125             


Ser Leu Leu Leu Ile Leu Thr Leu Leu Glu Leu Cys Val Thr Ile Ser 
    130                 135                 140                 


Thr Ile Ala Met Trp Cys Asn Ala Asn Cys Cys Asn Ser Arg Glu Glu 
145                 150                 155                 160 


Ile Ser Ser Pro Pro Asn Ser Val 
                165             


<210>  8967
<211>  83
<212>  PRT
<213>  Homo Sapiens

<400>  8967

Met Ala Ser His Glu Val Asp Asn Ala Glu Leu Gly Ser Ala Ser Ala 
1               5                   10                  15      


His Gly Thr Pro Gly Ser Glu Ala Gly Pro Glu Glu Leu Asn Thr Ser 
            20                  25                  30          


Val Tyr Gln Pro Ile Asp Gly Ser Pro Asp Tyr Gln Lys Ala Lys Leu 
        35                  40                  45              


Gln Val Leu Gly Ser Ile Gln Arg Glu Glu Asp Glu Asp Glu Asp Leu 
    50                  55                  60                  


Tyr Asp Asn Leu Leu Pro Leu Asn Glu Tyr Ser Val Val Gln Glu Pro 
65                  70                  75                  80  


Cys Leu Leu 
            


<210>  8968
<211>  91
<212>  PRT
<213>  Homo Sapiens

<400>  8968

Met Asn Ile Ala Ser Ala Thr Ile Ala Leu Val Gly Thr Ala Phe Leu 
1               5                   10                  15      


Ser Leu Asn Ile Ala Val Asn Ile Gln Ser Leu Arg Ser Cys His Ser 
            20                  25                  30          


Ser Ser Glu Ser Pro Asp Leu Cys Asn Tyr Met Gly Ser Ile Ser Asn 
        35                  40                  45              


Gly Met Val Ser Leu Leu Leu Ile Leu Thr Leu Leu Glu Leu Cys Val 
    50                  55                  60                  


Thr Ile Ser Thr Ile Ala Met Trp Cys Asn Ala Asn Cys Cys Asn Ser 
65                  70                  75                  80  


Arg Glu Glu Ile Ser Ser Pro Pro Asn Ser Val 
                85                  90      


<210>  8969
<211>  1137
<212>  PRT
<213>  Homo Sapiens

<400>  8969

Met Ser Arg Arg Lys Pro Ala Ser Gly Gly Leu Ala Ala Ser Ser Ser 
1               5                   10                  15      


Ala Pro Ala Arg Gln Ala Val Leu Ser Arg Phe Phe Gln Ser Thr Gly 
            20                  25                  30          


Ser Leu Lys Ser Thr Ser Ser Ser Thr Gly Ala Ala Asp Gln Val Asp 
        35                  40                  45              


Pro Gly Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Pro Pro 
    50                  55                  60                  


Ala Pro Pro Ala Pro Ala Phe Pro Pro Gln Leu Pro Pro His Ile Ala 
65                  70                  75                  80  


Thr Glu Ile Asp Arg Arg Lys Lys Arg Pro Leu Glu Asn Asp Gly Pro 
                85                  90                  95      


Val Lys Lys Lys Val Lys Lys Val Gln Gln Lys Glu Gly Gly Ser Asp 
            100                 105                 110         


Leu Gly Met Ser Gly Asn Ser Glu Pro Lys Lys Cys Leu Arg Thr Arg 
        115                 120                 125             


Asn Val Ser Lys Ser Leu Glu Lys Leu Lys Glu Phe Cys Cys Asp Ser 
    130                 135                 140                 


Ala Leu Pro Gln Ser Arg Val Gln Thr Glu Ser Leu Gln Glu Arg Phe 
145                 150                 155                 160 


Ala Val Leu Pro Lys Cys Thr Asp Phe Asp Asp Ile Ser Leu Leu His 
                165                 170                 175     


Ala Lys Asn Ala Val Ser Ser Glu Asp Ser Lys Arg Gln Ile Asn Gln 
            180                 185                 190         


Lys Asp Thr Thr Leu Phe Asp Leu Ser Gln Phe Gly Ser Ser Asn Thr 
        195                 200                 205             


Ser His Glu Asn Leu Gln Lys Thr Ala Ser Lys Ser Ala Asn Lys Arg 
    210                 215                 220                 


Ser Lys Ser Ile Tyr Thr Pro Leu Glu Leu Gln Tyr Ile Glu Met Lys 
225                 230                 235                 240 


Gln Gln His Lys Asp Ala Val Leu Cys Val Glu Cys Gly Tyr Lys Tyr 
                245                 250                 255     


Arg Phe Phe Gly Glu Asp Ala Glu Ile Ala Ala Arg Glu Leu Asn Ile 
            260                 265                 270         


Tyr Cys His Leu Asp His Asn Phe Met Thr Ala Ser Ile Pro Thr His 
        275                 280                 285             


Arg Leu Phe Val His Val Arg Arg Leu Val Ala Lys Gly Tyr Lys Val 
    290                 295                 300                 


Gly Val Val Lys Gln Thr Glu Thr Ala Ala Leu Lys Ala Ile Gly Asp 
305                 310                 315                 320 


Asn Arg Ser Ser Leu Phe Ser Arg Lys Leu Thr Ala Leu Tyr Thr Lys 
                325                 330                 335     


Ser Thr Leu Ile Gly Glu Asp Val Asn Pro Leu Ile Lys Leu Asp Asp 
            340                 345                 350         


Ala Val Asn Val Asp Glu Ile Met Thr Asp Thr Ser Thr Ser Tyr Leu 
        355                 360                 365             


Leu Cys Ile Ser Glu Asn Lys Glu Asn Val Arg Asp Lys Lys Lys Gly 
    370                 375                 380                 


Asn Ile Phe Ile Gly Ile Val Gly Val Gln Pro Ala Thr Gly Glu Val 
385                 390                 395                 400 


Val Phe Asp Ser Phe Gln Asp Ser Ala Ser Arg Ser Glu Leu Glu Thr 
                405                 410                 415     


Arg Met Ser Ser Leu Gln Pro Val Glu Leu Leu Leu Pro Ser Ala Leu 
            420                 425                 430         


Ser Glu Gln Thr Glu Ala Leu Ile His Arg Ala Thr Ser Val Ser Val 
        435                 440                 445             


Gln Asp Asp Arg Ile Arg Val Glu Arg Met Asp Asn Ile Tyr Phe Glu 
    450                 455                 460                 


Tyr Ser His Ala Phe Gln Ala Val Thr Glu Phe Tyr Ala Lys Asp Thr 
465                 470                 475                 480 


Val Asp Ile Lys Gly Ser Gln Ile Ile Ser Gly Ile Val Asn Leu Glu 
                485                 490                 495     


Lys Pro Val Ile Cys Ser Leu Ala Ala Ile Ile Lys Tyr Leu Lys Glu 
            500                 505                 510         


Phe Asn Leu Glu Lys Met Leu Ser Lys Pro Glu Asn Phe Lys Gln Leu 
        515                 520                 525             


Ser Ser Lys Met Glu Phe Met Thr Ile Asn Gly Thr Thr Leu Arg Asn 
    530                 535                 540                 


Leu Glu Ile Leu Gln Asn Gln Thr Asp Met Lys Thr Lys Gly Ser Leu 
545                 550                 555                 560 


Leu Trp Val Leu Asp His Thr Lys Thr Ser Phe Gly Arg Arg Lys Leu 
                565                 570                 575     


Lys Lys Trp Val Thr Gln Pro Leu Leu Lys Leu Arg Glu Ile Asn Ala 
            580                 585                 590         


Arg Leu Asp Ala Val Ser Glu Val Leu His Ser Glu Ser Ser Val Phe 
        595                 600                 605             


Gly Gln Ile Glu Asn His Leu Arg Lys Leu Pro Asp Ile Glu Arg Gly 
    610                 615                 620                 


Leu Cys Ser Ile Tyr His Lys Lys Cys Ser Thr Gln Glu Phe Phe Leu 
625                 630                 635                 640 


Ile Val Lys Thr Leu Tyr His Leu Lys Ser Glu Phe Gln Ala Ile Ile 
                645                 650                 655     


Pro Ala Val Asn Ser His Ile Gln Ser Asp Leu Leu Arg Thr Val Ile 
            660                 665                 670         


Leu Glu Ile Pro Glu Leu Leu Ser Pro Val Glu His Tyr Leu Lys Ile 
        675                 680                 685             


Leu Asn Glu Gln Ala Ala Lys Val Gly Asp Lys Thr Glu Leu Phe Lys 
    690                 695                 700                 


Asp Leu Ser Asp Phe Pro Leu Ile Lys Lys Arg Lys Asp Glu Ile Gln 
705                 710                 715                 720 


Gly Val Ile Asp Glu Ile Arg Met His Leu Gln Glu Ile Arg Lys Ile 
                725                 730                 735     


Leu Lys Asn Pro Ser Ala Gln Tyr Val Thr Val Ser Gly Gln Glu Phe 
            740                 745                 750         


Met Ile Glu Ile Lys Asn Ser Ala Val Ser Cys Ile Pro Thr Asp Trp 
        755                 760                 765             


Val Lys Val Gly Ser Thr Lys Ala Val Ser Arg Phe His Ser Pro Phe 
    770                 775                 780                 


Ile Val Glu Asn Tyr Arg His Leu Asn Gln Leu Arg Glu Gln Leu Val 
785                 790                 795                 800 


Leu Asp Cys Ser Ala Glu Trp Leu Asp Phe Leu Glu Lys Phe Ser Glu 
                805                 810                 815     


His Tyr His Ser Leu Cys Lys Ala Val His His Leu Ala Thr Val Asp 
            820                 825                 830         


Cys Ile Phe Ser Leu Ala Lys Val Ala Lys Gln Gly Asp Tyr Cys Arg 
        835                 840                 845             


Pro Thr Val Gln Glu Glu Arg Lys Ile Val Ile Lys Asn Gly Arg His 
    850                 855                 860                 


Pro Val Ile Asp Val Leu Leu Gly Glu Gln Asp Gln Tyr Val Pro Asn 
865                 870                 875                 880 


Asn Thr Asp Leu Ser Glu Asp Ser Glu Arg Val Met Ile Ile Thr Gly 
                885                 890                 895     


Pro Asn Met Gly Gly Lys Ser Ser Tyr Ile Lys Gln Val Ala Leu Ile 
            900                 905                 910         


Thr Ile Met Ala Gln Ile Gly Ser Tyr Val Pro Ala Glu Glu Ala Thr 
        915                 920                 925             


Ile Gly Ile Val Asp Gly Ile Phe Thr Arg Met Gly Ala Ala Asp Asn 
    930                 935                 940                 


Ile Tyr Lys Gly Gln Ser Thr Phe Met Glu Glu Leu Thr Asp Thr Ala 
945                 950                 955                 960 


Glu Ile Ile Arg Lys Ala Thr Ser Gln Ser Leu Val Ile Leu Asp Glu 
                965                 970                 975     


Leu Gly Arg Gly Thr Ser Thr His Asp Gly Ile Ala Ile Ala Tyr Ala 
            980                 985                 990         


Thr Leu Glu Tyr Phe Ile Arg Asp  Val Lys Ser Leu Thr  Leu Phe Val 
        995                 1000                 1005             


Thr His  Tyr Pro Pro Val Cys  Glu Leu Glu Lys Asn  Tyr Ser His 
    1010                 1015                 1020             


Gln Val  Gly Asn Tyr His Met  Gly Phe Leu Val Ser  Glu Asp Glu 
    1025                 1030                 1035             


Ser Lys  Leu Asp Pro Gly Ala  Ala Glu Gln Val Pro  Asp Phe Val 
    1040                 1045                 1050             


Thr Phe  Leu Tyr Gln Ile Thr  Arg Gly Ile Ala Ala  Arg Ser Tyr 
    1055                 1060                 1065             


Gly Leu  Asn Val Ala Lys Leu  Ala Asp Val Pro Gly  Glu Ile Leu 
    1070                 1075                 1080             


Lys Lys  Ala Ala His Lys Ser  Lys Glu Leu Glu Gly  Leu Ile Asn 
    1085                 1090                 1095             


Thr Lys  Arg Lys Arg Leu Lys  Tyr Phe Ala Lys Leu  Trp Thr Met 
    1100                 1105                 1110             


His Asn  Ala Gln Asp Leu Gln  Lys Trp Thr Glu Glu  Phe Asn Met 
    1115                 1120                 1125             


Glu Glu  Thr Gln Thr Ser Leu  Leu His 
    1130                 1135         


<210>  8970
<211>  166
<212>  PRT
<213>  Homo Sapiens

<400>  8970

Gly Tyr Ser Arg Pro Arg Tyr Ser Pro Gln Val Leu Gly Val Arg Ile 
1               5                   10                  15      


Gln Asn Gly Arg His Pro Leu Met Glu Leu Cys Ala Arg Thr Phe Val 
            20                  25                  30          


Pro Asn Ser Thr Glu Cys Gly Gly Asp Lys Gly Arg Val Lys Val Ile 
        35                  40                  45              


Thr Gly Pro Asn Ser Ser Gly Lys Ser Ile Tyr Leu Lys Gln Val Ala 
    50                  55                  60                  


Lys Ala Val Asn Asn Ala Thr Ala Gln Ser Leu Val Leu Ile Asp Glu 
65                  70                  75                  80  


Phe Gly Lys Gly Thr Asn Thr Val Asp Gly Leu Ala Leu Leu Ala Ala 
                85                  90                  95      


Val Leu Arg His Trp Leu Ala Arg Gly Pro Thr Cys Pro His Ile Phe 
            100                 105                 110         


Val Ala Thr Asn Phe Leu Ser Leu Val Gln Leu Gln Leu Leu Pro Gln 
        115                 120                 125             


Gly Pro Leu Val Gln Tyr Leu Asp Trp Pro Arg Val Ser Gly Gln Glu 
    130                 135                 140                 


Gly Gly Leu Arg Arg Cys Cys Glu Gly Gln Pro Cys Leu Pro His Ser 
145                 150                 155                 160 


Cys Pro Gly Trp Ala Ser 
                165     


<210>  8971
<211>  333
<212>  PRT
<213>  Homo Sapiens

<400>  8971

Lys Ile Leu Phe Leu Ser Ser Ile Ile Pro Phe Asp Cys Leu Leu Thr 
1               5                   10                  15      


Val Arg Ala Leu Gly Gly Leu Leu Lys Phe Leu Gly Arg Arg Arg Ile 
            20                  25                  30          


Gly Val Glu Leu Glu Asp Tyr Asn Val Ser Val Pro Ile Leu Gly Phe 
        35                  40                  45              


Lys Lys Phe Met Leu Thr His Leu Val Asn Ile Asp Gln Asp Thr Tyr 
    50                  55                  60                  


Ser Val Leu Gln Ile Phe Lys Ser Glu Ser His Pro Ser Val Tyr Lys 
65                  70                  75                  80  


Val Ala Ser Gly Leu Lys Glu Gly Leu Ser Leu Phe Gly Ile Leu Asn 
                85                  90                  95      


Arg Cys His Cys Lys Trp Gly Glu Lys Leu Leu Arg Leu Trp Phe Thr 
            100                 105                 110         


Arg Pro Thr His Asp Leu Gly Glu Leu Ser Ser Arg Leu Asp Val Ile 
        115                 120                 125             


Gln Phe Phe Leu Leu Pro Gln Asn Leu Asp Met Ala Gln Met Leu His 
    130                 135                 140                 


Arg Leu Leu Gly His Ile Lys Asn Val Pro Leu Ile Leu Lys Arg Met 
145                 150                 155                 160 


Lys Leu Ser His Thr Lys Val Ser Asp Trp Gln Val Leu Tyr Lys Thr 
                165                 170                 175     


Val Tyr Ser Ala Leu Gly Leu Arg Asp Ala Cys Arg Ser Leu Pro Gln 
            180                 185                 190         


Ser Ile Gln Leu Phe Arg Asp Ile Ala Gln Glu Phe Ser Asp Asp Leu 
        195                 200                 205             


His His Ile Ala Ser Leu Ile Gly Lys Val Tyr Leu Ser Pro Gln Val 
    210                 215                 220                 


Asp Phe Glu Gly Ser Leu Ala Glu Asn Arg Phe Thr Val Leu Pro Asn 
225                 230                 235                 240 


Ile Asp Pro Glu Ile Asp Glu Lys Lys Arg Arg Leu Met Gly Leu Pro 
                245                 250                 255     


Ser Phe Leu Thr Glu Val Ala Arg Lys Glu Leu Glu Asn Leu Asp Ser 
            260                 265                 270         


Arg Ile Pro Ser Cys Ser Val Ile Tyr Ile Pro Leu Ile Gly Phe Leu 
        275                 280                 285             


Leu Ser Ile Pro Arg Leu Pro Ser Met Val Glu Ala Ser Asp Phe Glu 
    290                 295                 300                 


Ile Asn Gly Leu Asp Phe Met Phe Leu Ser Glu Glu Lys Leu His Tyr 
305                 310                 315                 320 


Arg Ser Ala Arg Thr Lys Glu Leu Asp Ala Leu Leu Gly 
                325                 330             


<210>  8972
<211>  822
<212>  PRT
<213>  Homo Sapiens

<400>  8972

Met Ala Ser Leu Gly Ala Asn Pro Arg Arg Thr Pro Gln Gly Pro Arg 
1               5                   10                  15      


Pro Gly Ala Ala Ser Ser Gly Phe Pro Ser Pro Ala Pro Val Pro Gly 
            20                  25                  30          


Pro Arg Glu Ala Glu Glu Glu Glu Val Glu Glu Glu Glu Glu Leu Ala 
        35                  40                  45              


Glu Ile His Leu Cys Val Leu Trp Asn Ser Gly Tyr Leu Gly Ile Ala 
    50                  55                  60                  


Tyr Tyr Asp Thr Ser Asp Ser Thr Ile His Phe Met Pro Asp Ala Pro 
65                  70                  75                  80  


Asp His Glu Ser Leu Lys Leu Leu Gln Arg Val Leu Asp Glu Ile Asn 
                85                  90                  95      


Pro Gln Ser Val Val Thr Ser Ala Lys Gln Asp Glu Asn Met Thr Arg 
            100                 105                 110         


Phe Leu Gly Lys Leu Ala Ser Gln Glu His Arg Glu Pro Lys Arg Pro 
        115                 120                 125             


Glu Ile Ile Phe Leu Pro Ser Val Asp Phe Gly Leu Glu Ile Ser Lys 
    130                 135                 140                 


Gln Arg Leu Leu Ser Gly Asn Tyr Ser Phe Ile Pro Asp Ala Met Thr 
145                 150                 155                 160 


Ala Thr Glu Lys Ile Leu Phe Leu Ser Ser Ile Ile Pro Phe Asp Cys 
                165                 170                 175     


Leu Leu Thr Pro Pro Gly Asp Leu Arg Phe Thr Pro Ile Pro Leu Leu 
            180                 185                 190         


Ile Pro Ser Gln Val Arg Ala Leu Gly Gly Leu Leu Lys Phe Leu Gly 
        195                 200                 205             


Arg Arg Arg Ile Gly Val Glu Leu Glu Asp Tyr Asn Val Ser Val Pro 
    210                 215                 220                 


Ile Leu Gly Phe Lys Lys Phe Met Leu Thr His Leu Val Asn Ile Asp 
225                 230                 235                 240 


Gln Asp Thr Tyr Ser Val Leu Gln Ile Phe Lys Ser Glu Ser His Pro 
                245                 250                 255     


Ser Val Tyr Lys Val Ala Ser Gly Leu Lys Glu Gly Leu Ser Leu Phe 
            260                 265                 270         


Gly Ile Leu Asn Arg Cys His Cys Lys Trp Gly Glu Lys Leu Leu Arg 
        275                 280                 285             


Leu Trp Phe Thr Arg Pro Thr His Asp Leu Gly Glu Leu Ser Ser Arg 
    290                 295                 300                 


Leu Asp Val Ile Gln Phe Phe Leu Leu Pro Gln Asn Leu Asp Met Ala 
305                 310                 315                 320 


Gln Met Leu His Arg Leu Leu Gly His Ile Lys Asn Val Pro Leu Ile 
                325                 330                 335     


Leu Lys Arg Met Lys Leu Ser His Thr Lys Val Ser Asp Trp Gln Val 
            340                 345                 350         


Leu Tyr Lys Thr Val Tyr Ser Ala Leu Gly Leu Arg Asp Ala Cys Arg 
        355                 360                 365             


Ser Leu Pro Gln Ser Ile Gln Leu Phe Arg Asp Ile Ala Gln Glu Phe 
    370                 375                 380                 


Ser Asp Asp Leu His His Ile Ala Ser Leu Ile Gly Lys Val Val Asp 
385                 390                 395                 400 


Phe Glu Gly Ser Leu Ala Glu Asn Arg Phe Thr Val Leu Pro Asn Ile 
                405                 410                 415     


Asp Pro Glu Ile Asp Glu Lys Lys Arg Arg Leu Met Gly Leu Pro Ser 
            420                 425                 430         


Phe Leu Thr Glu Val Ala Arg Lys Glu Leu Glu Asn Leu Asp Ser Arg 
        435                 440                 445             


Ile Pro Ser Cys Ser Val Ile Tyr Ile Pro Leu Ile Gly Phe Leu Leu 
    450                 455                 460                 


Ser Ile Pro Arg Leu Pro Ser Met Val Glu Ala Ser Asp Phe Glu Ile 
465                 470                 475                 480 


Asn Gly Leu Asp Phe Met Phe Leu Ser Glu Glu Lys Leu His Tyr Arg 
                485                 490                 495     


Ser Ala Arg Thr Lys Glu Leu Asp Ala Leu Leu Gly Asp Leu His Cys 
            500                 505                 510         


Glu Ile Arg Asp Gln Glu Thr Leu Leu Met Tyr Gln Leu Gln Cys Gln 
        515                 520                 525             


Val Leu Ala Arg Ala Ala Val Leu Thr Arg Val Leu Asp Leu Ala Ser 
    530                 535                 540                 


Arg Leu Asp Val Leu Leu Ala Leu Ala Ser Ala Ala Arg Asp Tyr Gly 
545                 550                 555                 560 


Tyr Ser Arg Pro Arg Tyr Ser Pro Gln Val Leu Gly Val Arg Ile Gln 
                565                 570                 575     


Asn Gly Arg His Pro Leu Met Glu Leu Cys Ala Arg Thr Phe Val Pro 
            580                 585                 590         


Asn Ser Thr Glu Cys Gly Gly Asp Lys Gly Arg Val Lys Val Ile Thr 
        595                 600                 605             


Gly Pro Asn Ser Ser Gly Lys Ser Ile Tyr Leu Lys Gln Val Gly Leu 
    610                 615                 620                 


Ile Thr Phe Met Ala Leu Val Gly Ser Phe Val Pro Ala Glu Glu Ala 
625                 630                 635                 640 


Glu Ile Gly Ala Val Asp Ala Ile Phe Thr Arg Ile His Ser Cys Glu 
                645                 650                 655     


Ser Ile Ser Leu Gly Leu Ser Thr Phe Met Ile Asp Leu Asn Gln Gln 
            660                 665                 670         


Val Ala Lys Ala Val Asn Asn Ala Thr Ala Gln Ser Leu Val Leu Ile 
        675                 680                 685             


Asp Glu Phe Gly Lys Gly Thr Asn Thr Val Asp Gly Leu Ala Leu Leu 
    690                 695                 700                 


Ala Ala Val Leu Arg His Trp Leu Ala Arg Gly Pro Thr Cys Pro His 
705                 710                 715                 720 


Ile Phe Val Ala Thr Asn Phe Leu Ser Leu Val Gln Leu Gln Leu Leu 
                725                 730                 735     


Pro Gln Gly Pro Leu Val Gln Tyr Leu Thr Met Glu Thr Cys Glu Asp 
            740                 745                 750         


Gly Asn Asp Leu Val Phe Phe Tyr Gln Val Ser Asp Leu Ile Arg Ser 
        755                 760                 765             


Gly Lys Pro Ile Lys Pro Val Lys Asp Leu Leu Lys Lys Asn Gln Met 
    770                 775                 780                 


Glu Asn Cys Gln Thr Leu Val Asp Lys Phe Met Lys Leu Asp Leu Glu 
785                 790                 795                 800 


Asp Pro Asn Leu Asp Leu Asn Val Phe Met Ser Gln Glu Val Leu Pro 
                805                 810                 815     


Ala Ala Thr Ser Ile Leu 
            820         


<210>  8973
<211>  194
<212>  PRT
<213>  Homo Sapiens

<400>  8973

Met Ala Ser Leu Gly Ala Asn Pro Arg Arg Thr Pro Gln Gly Pro Arg 
1               5                   10                  15      


Pro Gly Ala Ala Ser Ser Gly Phe Pro Ser Pro Ala Pro Val Pro Gly 
            20                  25                  30          


Pro Arg Glu Ala Glu Glu Glu Glu Val Glu Glu Glu Glu Glu Leu Ala 
        35                  40                  45              


Glu Ile His Leu Cys Val Leu Trp Asn Ser Gly Tyr Leu Gly Ile Ala 
    50                  55                  60                  


Tyr Tyr Asp Thr Ser Asp Ser Thr Ile His Phe Met Pro Asp Ala Pro 
65                  70                  75                  80  


Asp His Glu Ser Leu Lys Leu Leu Gln Arg Val Leu Asp Glu Ile Asn 
                85                  90                  95      


Pro Gln Ser Val Val Thr Ser Ala Lys Gln Asp Glu Asn Met Thr Arg 
            100                 105                 110         


Phe Leu Gly Lys Leu Ala Ser Gln Glu His Arg Glu Pro Lys Arg Pro 
        115                 120                 125             


Glu Ile Ile Phe Leu Pro Ser Val Asp Phe Gly Leu Glu Ile Ser Lys 
    130                 135                 140                 


Gln Arg Leu Leu Ser Gly Asn Tyr Ser Phe Ile Pro Asp Ala Met Thr 
145                 150                 155                 160 


Ala Thr Glu Lys Ile Leu Phe Leu Ser Ser Ile Ile Pro Phe Asp Cys 
                165                 170                 175     


Leu Leu Thr Val Arg Ala Leu Gly Gly Leu Leu Lys Phe Leu Gly Arg 
            180                 185                 190         


Arg Arg 
        


<210>  8974
<211>  834
<212>  PRT
<213>  Homo Sapiens

<400>  8974

Met Ala Ser Leu Gly Ala Asn Pro Arg Arg Thr Pro Gln Gly Pro Arg 
1               5                   10                  15      


Pro Gly Ala Ala Ser Ser Gly Phe Pro Ser Pro Ala Pro Val Pro Gly 
            20                  25                  30          


Pro Arg Glu Ala Glu Glu Glu Glu Val Glu Glu Glu Glu Glu Leu Ala 
        35                  40                  45              


Glu Ile His Leu Cys Val Leu Trp Asn Ser Gly Tyr Leu Gly Ile Ala 
    50                  55                  60                  


Tyr Tyr Asp Thr Ser Asp Ser Thr Ile His Phe Met Pro Asp Ala Pro 
65                  70                  75                  80  


Asp His Glu Ser Leu Lys Leu Leu Gln Arg Val Leu Asp Glu Ile Asn 
                85                  90                  95      


Pro Gln Ser Val Val Thr Ser Ala Lys Gln Asp Glu Asn Met Thr Arg 
            100                 105                 110         


Phe Leu Gly Lys Leu Ala Ser Gln Glu His Arg Glu Pro Lys Arg Pro 
        115                 120                 125             


Glu Ile Ile Phe Leu Pro Ser Val Asp Phe Gly Leu Glu Ile Ser Lys 
    130                 135                 140                 


Gln Arg Leu Leu Ser Gly Asn Tyr Ser Phe Ile Pro Asp Ala Met Thr 
145                 150                 155                 160 


Ala Thr Glu Lys Ile Leu Phe Leu Ser Ser Ile Ile Pro Phe Asp Cys 
                165                 170                 175     


Leu Leu Thr Val Arg Ala Leu Gly Gly Leu Leu Lys Phe Leu Gly Arg 
            180                 185                 190         


Arg Arg Ile Gly Val Glu Leu Glu Asp Tyr Asn Val Ser Val Pro Ile 
        195                 200                 205             


Leu Gly Phe Lys Lys Phe Met Leu Thr His Leu Val Asn Ile Asp Gln 
    210                 215                 220                 


Asp Thr Tyr Ser Val Leu Gln Ile Phe Lys Ser Glu Ser His Pro Ser 
225                 230                 235                 240 


Val Tyr Lys Val Ala Ser Gly Leu Lys Glu Gly Leu Ser Leu Phe Gly 
                245                 250                 255     


Ile Leu Asn Arg Cys His Cys Lys Trp Gly Glu Lys Leu Leu Arg Leu 
            260                 265                 270         


Trp Phe Thr Arg Pro Thr His Asp Leu Gly Glu Leu Ser Ser Arg Leu 
        275                 280                 285             


Asp Val Ile Gln Phe Phe Leu Leu Pro Gln Asn Leu Asp Met Ala Gln 
    290                 295                 300                 


Met Leu His Arg Leu Leu Gly His Ile Lys Asn Val Pro Leu Ile Leu 
305                 310                 315                 320 


Lys Arg Met Lys Leu Ser His Thr Lys Val Ser Asp Trp Gln Val Leu 
                325                 330                 335     


Tyr Lys Thr Val Tyr Ser Ala Leu Gly Leu Arg Asp Ala Cys Arg Ser 
            340                 345                 350         


Leu Pro Gln Ser Ile Gln Leu Phe Arg Asp Ile Ala Gln Glu Phe Ser 
        355                 360                 365             


Asp Asp Leu His His Ile Ala Ser Leu Ile Gly Lys Val Val Asp Phe 
    370                 375                 380                 


Glu Gly Ser Leu Ala Glu Asn Arg Phe Thr Val Leu Pro Asn Ile Asp 
385                 390                 395                 400 


Pro Glu Ile Asp Glu Lys Lys Arg Arg Leu Met Gly Leu Pro Ser Phe 
                405                 410                 415     


Leu Thr Glu Val Ala Arg Lys Glu Leu Glu Asn Leu Asp Ser Arg Ile 
            420                 425                 430         


Pro Ser Cys Ser Val Ile Tyr Ile Pro Leu Ile Gly Phe Leu Leu Ser 
        435                 440                 445             


Ile Pro Arg Leu Pro Ser Met Val Glu Ala Ser Asp Phe Glu Ile Asn 
    450                 455                 460                 


Gly Leu Asp Phe Met Phe Leu Ser Glu Glu Lys Leu His Tyr Arg Ser 
465                 470                 475                 480 


Ala Arg Thr Lys Glu Leu Asp Ala Leu Leu Gly Asp Leu His Cys Glu 
                485                 490                 495     


Ile Arg Asp Gln Glu Thr Leu Leu Met Tyr Gln Leu Gln Cys Gln Val 
            500                 505                 510         


Leu Ala Arg Ala Ala Val Leu Thr Arg Val Leu Asp Leu Ala Ser Arg 
        515                 520                 525             


Leu Asp Val Leu Leu Ala Leu Ala Ser Ala Ala Arg Asp Tyr Gly Tyr 
    530                 535                 540                 


Ser Arg Pro Arg Tyr Ser Pro Gln Val Leu Gly Val Arg Ile Gln Asn 
545                 550                 555                 560 


Gly Arg His Pro Leu Met Glu Leu Cys Ala Arg Thr Phe Val Pro Asn 
                565                 570                 575     


Ser Thr Glu Cys Gly Gly Asp Lys Gly Arg Val Lys Val Ile Thr Gly 
            580                 585                 590         


Pro Asn Ser Ser Gly Lys Ser Ile Tyr Leu Lys Gln Val Gly Leu Ile 
        595                 600                 605             


Thr Phe Met Ala Leu Val Gly Ser Phe Val Pro Ala Glu Glu Ala Glu 
    610                 615                 620                 


Ile Gly Ala Val Asp Ala Ile Phe Thr Arg Ile His Ser Cys Glu Ser 
625                 630                 635                 640 


Ile Ser Leu Gly Leu Ser Thr Phe Met Ile Asp Leu Asn Gln Val Ala 
                645                 650                 655     


Lys Ala Val Asn Asn Ala Thr Ala Gln Ser Leu Val Leu Ile Asp Glu 
            660                 665                 670         


Phe Gly Lys Gly Thr Asn Thr Val Asp Gly Leu Ala Leu Leu Ala Ala 
        675                 680                 685             


Val Leu Arg His Trp Leu Ala Arg Gly Pro Thr Cys Pro His Ile Phe 
    690                 695                 700                 


Val Ala Thr Asn Phe Leu Ser Leu Val Gln Leu Gln Leu Leu Pro Gln 
705                 710                 715                 720 


Gly Pro Leu Val Gln Tyr Leu Thr Met Glu Thr Cys Glu Asp Gly Asn 
                725                 730                 735     


Asp Leu Val Phe Phe Tyr Gln Val Cys Glu Gly Val Ala Lys Ala Ser 
            740                 745                 750         


His Ala Ser His Thr Ala Ala Gln Ala Gly Leu Pro Asp Lys Leu Val 
        755                 760                 765             


Ala Arg Gly Lys Glu Val Ser Asp Leu Ile Arg Ser Gly Lys Pro Ile 
    770                 775                 780                 


Lys Pro Val Lys Asp Leu Leu Lys Lys Asn Gln Met Glu Asn Cys Gln 
785                 790                 795                 800 


Thr Leu Val Asp Lys Phe Met Lys Leu Asp Leu Glu Asp Pro Asn Leu 
                805                 810                 815     


Asp Leu Asn Val Phe Met Ser Gln Glu Val Leu Pro Ala Ala Thr Ser 
            820                 825                 830         


Ile Leu 
        


<210>  8975
<211>  835
<212>  PRT
<213>  Homo Sapiens

<400>  8975

Met Ala Ser Leu Gly Ala Asn Pro Arg Arg Thr Pro Gln Gly Pro Arg 
1               5                   10                  15      


Pro Gly Ala Ala Ser Ser Gly Phe Pro Ser Pro Ala Pro Val Pro Gly 
            20                  25                  30          


Pro Arg Glu Ala Glu Glu Glu Glu Val Glu Glu Glu Glu Glu Leu Ala 
        35                  40                  45              


Glu Ile His Leu Cys Val Leu Trp Asn Ser Gly Tyr Leu Gly Ile Ala 
    50                  55                  60                  


Tyr Tyr Asp Thr Ser Asp Ser Thr Ile His Phe Met Pro Asp Ala Pro 
65                  70                  75                  80  


Asp His Glu Ser Leu Lys Leu Leu Gln Arg Val Leu Asp Glu Ile Asn 
                85                  90                  95      


Pro Gln Ser Val Val Thr Ser Ala Lys Gln Asp Glu Asn Met Thr Arg 
            100                 105                 110         


Phe Leu Gly Lys Leu Ala Ser Gln Glu His Arg Glu Pro Lys Arg Pro 
        115                 120                 125             


Glu Ile Ile Phe Leu Pro Ser Val Asp Phe Gly Leu Glu Ile Ser Lys 
    130                 135                 140                 


Gln Arg Leu Leu Ser Gly Asn Tyr Ser Phe Ile Pro Asp Ala Met Thr 
145                 150                 155                 160 


Ala Thr Glu Lys Ile Leu Phe Leu Ser Ser Ile Ile Pro Phe Asp Cys 
                165                 170                 175     


Leu Leu Thr Val Arg Ala Leu Gly Gly Leu Leu Lys Phe Leu Gly Arg 
            180                 185                 190         


Arg Arg Ile Gly Val Glu Leu Glu Asp Tyr Asn Val Ser Val Pro Ile 
        195                 200                 205             


Leu Gly Phe Lys Lys Phe Met Leu Thr His Leu Val Asn Ile Asp Gln 
    210                 215                 220                 


Asp Thr Tyr Ser Val Leu Gln Ile Phe Lys Ser Glu Ser His Pro Ser 
225                 230                 235                 240 


Val Tyr Lys Val Ala Ser Gly Leu Lys Glu Gly Leu Ser Leu Phe Gly 
                245                 250                 255     


Ile Leu Asn Arg Cys His Cys Lys Trp Gly Glu Lys Leu Leu Arg Leu 
            260                 265                 270         


Trp Phe Thr Arg Pro Thr His Asp Leu Gly Glu Leu Ser Ser Arg Leu 
        275                 280                 285             


Asp Val Ile Gln Phe Phe Leu Leu Pro Gln Asn Leu Asp Met Ala Gln 
    290                 295                 300                 


Met Leu His Arg Leu Leu Gly His Ile Lys Asn Val Pro Leu Ile Leu 
305                 310                 315                 320 


Lys Arg Met Lys Leu Ser His Thr Lys Val Ser Asp Trp Gln Val Leu 
                325                 330                 335     


Tyr Lys Thr Val Tyr Ser Ala Leu Gly Leu Arg Asp Ala Cys Arg Ser 
            340                 345                 350         


Leu Pro Gln Ser Ile Gln Leu Phe Arg Asp Ile Ala Gln Glu Phe Ser 
        355                 360                 365             


Asp Asp Leu His His Ile Ala Ser Leu Ile Gly Lys Val Val Asp Phe 
    370                 375                 380                 


Glu Gly Ser Leu Ala Glu Asn Arg Phe Thr Val Leu Pro Asn Ile Asp 
385                 390                 395                 400 


Pro Glu Ile Asp Glu Lys Lys Arg Arg Leu Met Gly Leu Pro Ser Phe 
                405                 410                 415     


Leu Thr Glu Val Ala Arg Lys Glu Leu Glu Asn Leu Asp Ser Arg Ile 
            420                 425                 430         


Pro Ser Cys Ser Val Ile Tyr Ile Pro Leu Ile Gly Phe Leu Leu Ser 
        435                 440                 445             


Ile Pro Arg Leu Pro Ser Met Val Glu Ala Ser Asp Phe Glu Ile Asn 
    450                 455                 460                 


Gly Leu Asp Phe Met Phe Leu Ser Glu Glu Lys Leu His Tyr Arg Ser 
465                 470                 475                 480 


Ala Arg Thr Lys Glu Leu Asp Ala Leu Leu Gly Asp Leu His Cys Glu 
                485                 490                 495     


Ile Arg Asp Gln Glu Thr Leu Leu Met Tyr Gln Leu Gln Cys Gln Val 
            500                 505                 510         


Leu Ala Arg Ala Ala Val Leu Thr Arg Val Leu Asp Leu Ala Ser Arg 
        515                 520                 525             


Leu Asp Val Leu Leu Ala Leu Ala Ser Ala Ala Arg Asp Tyr Gly Tyr 
    530                 535                 540                 


Ser Arg Pro Arg Tyr Ser Pro Gln Val Leu Gly Val Arg Ile Gln Asn 
545                 550                 555                 560 


Gly Arg His Pro Leu Met Glu Leu Cys Ala Arg Thr Phe Val Pro Asn 
                565                 570                 575     


Ser Thr Glu Cys Gly Gly Asp Lys Gly Arg Val Lys Val Ile Thr Gly 
            580                 585                 590         


Pro Asn Ser Ser Gly Lys Ser Ile Tyr Leu Lys Gln Val Gly Leu Ile 
        595                 600                 605             


Thr Phe Met Ala Leu Val Gly Ser Phe Val Pro Ala Glu Glu Ala Glu 
    610                 615                 620                 


Ile Gly Ala Val Asp Ala Ile Phe Thr Arg Ile His Ser Cys Glu Ser 
625                 630                 635                 640 


Ile Ser Leu Gly Leu Ser Thr Phe Met Ile Asp Leu Asn Gln Gln Val 
                645                 650                 655     


Ala Lys Ala Val Asn Asn Ala Thr Ala Gln Ser Leu Val Leu Ile Asp 
            660                 665                 670         


Glu Phe Gly Lys Gly Thr Asn Thr Val Asp Gly Leu Ala Leu Leu Ala 
        675                 680                 685             


Ala Val Leu Arg His Trp Leu Ala Arg Gly Pro Thr Cys Pro His Ile 
    690                 695                 700                 


Phe Val Ala Thr Asn Phe Leu Ser Leu Val Gln Leu Gln Leu Leu Pro 
705                 710                 715                 720 


Gln Gly Pro Leu Val Gln Tyr Leu Thr Met Glu Thr Cys Glu Asp Gly 
                725                 730                 735     


Asn Asp Leu Val Phe Phe Tyr Gln Val Cys Glu Gly Val Ala Lys Ala 
            740                 745                 750         


Ser His Ala Ser His Thr Ala Ala Gln Ala Gly Leu Pro Asp Lys Leu 
        755                 760                 765             


Val Ala Arg Gly Lys Glu Val Ser Asp Leu Ile Arg Ser Gly Lys Pro 
    770                 775                 780                 


Ile Lys Pro Val Lys Asp Leu Leu Lys Lys Asn Gln Met Glu Asn Cys 
785                 790                 795                 800 


Gln Thr Leu Val Asp Lys Phe Met Lys Leu Asp Leu Glu Asp Pro Asn 
                805                 810                 815     


Leu Asp Leu Asn Val Phe Met Ser Gln Glu Val Leu Pro Ala Ala Thr 
            820                 825                 830         


Ser Ile Leu 
        835 


<210>  8976
<211>  834
<212>  PRT
<213>  Homo Sapiens

<400>  8976

Met Ala Ser Leu Gly Ala Asn Pro Arg Arg Thr Pro Gln Gly Pro Arg 
1               5                   10                  15      


Pro Gly Ala Ala Ser Ser Gly Phe Pro Ser Pro Ala Pro Val Pro Gly 
            20                  25                  30          


Pro Arg Glu Ala Glu Glu Glu Glu Val Glu Glu Glu Glu Glu Leu Ala 
        35                  40                  45              


Glu Ile His Leu Cys Val Leu Trp Asn Ser Gly Tyr Leu Gly Ile Ala 
    50                  55                  60                  


Tyr Tyr Asp Thr Ser Asp Ser Thr Ile His Phe Met Pro Asp Ala Pro 
65                  70                  75                  80  


Asp His Glu Ser Leu Lys Leu Leu Gln Arg Val Leu Asp Glu Ile Asn 
                85                  90                  95      


Pro Gln Ser Val Val Thr Ser Ala Lys Gln Asp Glu Asn Met Thr Arg 
            100                 105                 110         


Phe Leu Gly Lys Leu Ala Ser Gln Glu His Arg Glu Pro Lys Arg Pro 
        115                 120                 125             


Glu Ile Ile Phe Leu Pro Ser Val Asp Phe Gly Leu Glu Ile Ser Lys 
    130                 135                 140                 


Gln Arg Leu Leu Ser Gly Asn Tyr Ser Phe Ile Pro Asp Ala Met Thr 
145                 150                 155                 160 


Ala Thr Glu Lys Ile Leu Phe Leu Ser Ser Ile Ile Pro Phe Asp Cys 
                165                 170                 175     


Leu Leu Thr Val Arg Ala Leu Gly Gly Leu Leu Lys Phe Leu Gly Arg 
            180                 185                 190         


Arg Arg Ile Gly Val Glu Leu Glu Asp Tyr Asn Val Ser Val Pro Ile 
        195                 200                 205             


Leu Gly Phe Lys Lys Phe Met Leu Thr His Leu Val Asn Ile Asp Gln 
    210                 215                 220                 


Asp Thr Tyr Ser Val Leu Gln Ile Phe Lys Ser Glu Ser His Pro Ser 
225                 230                 235                 240 


Val Tyr Lys Val Ala Ser Gly Leu Lys Glu Gly Leu Ser Leu Phe Gly 
                245                 250                 255     


Ile Leu Asn Arg Cys His Cys Lys Trp Gly Glu Lys Leu Leu Arg Leu 
            260                 265                 270         


Trp Phe Thr Arg Pro Thr His Asp Leu Gly Glu Leu Ser Ser Arg Leu 
        275                 280                 285             


Asp Val Ile Gln Phe Phe Leu Leu Pro Gln Asn Leu Asp Met Ala Gln 
    290                 295                 300                 


Met Leu His Arg Leu Leu Gly His Ile Lys Asn Val Pro Leu Ile Leu 
305                 310                 315                 320 


Lys Arg Met Lys Leu Ser His Thr Lys Val Ser Asp Trp Gln Val Leu 
                325                 330                 335     


Tyr Lys Thr Val Tyr Ser Ala Leu Gly Leu Arg Asp Ala Cys Arg Ser 
            340                 345                 350         


Leu Pro Gln Ser Ile Gln Leu Phe Arg Asp Ile Ala Gln Glu Phe Ser 
        355                 360                 365             


Asp Asp Leu His His Ile Ala Ser Leu Ile Gly Lys Val Val Asp Phe 
    370                 375                 380                 


Glu Gly Ser Leu Ala Glu Asn Arg Phe Thr Val Leu Pro Asn Ile Asp 
385                 390                 395                 400 


Pro Glu Ile Asp Glu Lys Lys Arg Arg Leu Met Gly Leu Pro Ser Phe 
                405                 410                 415     


Leu Thr Glu Val Ala Arg Lys Glu Leu Glu Asn Leu Asp Ser Arg Ile 
            420                 425                 430         


Pro Ser Cys Ser Val Ile Tyr Ile Pro Leu Ile Gly Phe Leu Leu Ser 
        435                 440                 445             


Ile Pro Arg Leu Pro Ser Met Val Glu Ala Ser Asp Phe Glu Ile Asn 
    450                 455                 460                 


Gly Leu Asp Phe Met Phe Leu Ser Glu Glu Lys Leu His Tyr Arg Ser 
465                 470                 475                 480 


Ala Arg Thr Lys Glu Leu Asp Ala Leu Leu Gly Asp Leu His Cys Glu 
                485                 490                 495     


Ile Arg Asp Gln Glu Thr Leu Leu Met Tyr Gln Leu Gln Cys Gln Val 
            500                 505                 510         


Leu Ala Arg Ala Ala Val Leu Thr Arg Val Leu Asp Leu Ala Ser Arg 
        515                 520                 525             


Leu Asp Val Leu Leu Ala Leu Ala Ser Ala Ala Arg Asp Tyr Gly Tyr 
    530                 535                 540                 


Ser Arg Pro Arg Tyr Ser Pro Gln Val Leu Gly Val Arg Ile Gln Asn 
545                 550                 555                 560 


Gly Arg His Pro Leu Met Glu Leu Cys Ala Arg Thr Phe Val Pro Asn 
                565                 570                 575     


Ser Thr Glu Cys Gly Gly Asp Lys Gly Arg Val Lys Val Ile Thr Gly 
            580                 585                 590         


Pro Asn Ser Ser Gly Lys Ser Ile Tyr Leu Lys Gln Val Gly Leu Ile 
        595                 600                 605             


Thr Phe Met Ala Leu Val Gly Ser Phe Val Pro Ala Glu Glu Ala Glu 
    610                 615                 620                 


Ile Gly Ala Val Asp Ala Ile Phe Thr Arg Ile His Ser Cys Glu Ser 
625                 630                 635                 640 


Ile Ser Leu Gly Leu Ser Thr Phe Met Ile Asp Leu Asn Gln Val Ala 
                645                 650                 655     


Lys Ala Val Asn Asn Ala Thr Ala Gln Ser Leu Val Leu Ile Asp Glu 
            660                 665                 670         


Phe Gly Lys Gly Thr Asn Thr Val Asp Gly Leu Ala Leu Leu Ala Ala 
        675                 680                 685             


Val Leu Arg His Trp Leu Ala Arg Gly Pro Thr Cys Pro His Ile Phe 
    690                 695                 700                 


Val Ala Thr Asn Phe Leu Ser Leu Val Gln Leu Gln Leu Leu Pro Gln 
705                 710                 715                 720 


Gly Pro Leu Val Gln Tyr Leu Thr Met Glu Thr Cys Glu Asp Gly Asn 
                725                 730                 735     


Asp Leu Val Phe Phe Tyr Gln Val Cys Glu Gly Val Ala Lys Ala Ser 
            740                 745                 750         


His Ala Ser His Thr Ala Ala Gln Ala Gly Leu Pro Asp Lys Leu Val 
        755                 760                 765             


Ala Arg Gly Lys Glu Val Ser Asp Leu Ile Arg Ser Gly Lys Pro Ile 
    770                 775                 780                 


Lys Pro Val Lys Asp Leu Leu Lys Lys Asn Gln Met Glu Asn Cys Gln 
785                 790                 795                 800 


Thr Leu Val Asp Lys Phe Met Lys Leu Asp Leu Glu Asp Pro Asn Leu 
                805                 810                 815     


Asp Leu Asn Val Phe Met Ser Gln Glu Val Leu Pro Ala Ala Thr Ser 
            820                 825                 830         


Ile Leu 
        


<210>  8977
<211>  637
<212>  PRT
<213>  Homo Sapiens

<400>  8977

Met Ala Ser Leu Gly Ala Asn Pro Arg Arg Thr Pro Gln Gly Pro Arg 
1               5                   10                  15      


Pro Gly Ala Ala Ser Ser Gly Phe Pro Ser Pro Ala Pro Val Pro Gly 
            20                  25                  30          


Pro Arg Glu Ala Glu Glu Glu Glu Val Glu Glu Glu Glu Glu Leu Ala 
        35                  40                  45              


Glu Ile His Leu Cys Val Leu Trp Asn Ser Gly Tyr Leu Gly Ile Ala 
    50                  55                  60                  


Tyr Tyr Asp Thr Ser Asp Ser Thr Ile His Phe Met Pro Asp Ala Pro 
65                  70                  75                  80  


Asp His Glu Ser Leu Lys Leu Leu Gln Arg Val Leu Asp Glu Ile Asn 
                85                  90                  95      


Pro Gln Ser Val Val Thr Ser Ala Lys Gln Asp Glu Asn Met Thr Arg 
            100                 105                 110         


Phe Leu Gly Lys Leu Ala Ser Gln Glu His Arg Glu Pro Lys Arg Pro 
        115                 120                 125             


Glu Ile Ile Phe Leu Pro Ser Val Asp Phe Gly Leu Glu Ile Ser Lys 
    130                 135                 140                 


Gln Arg Leu Leu Ser Gly Asn Tyr Ser Phe Ile Pro Asp Ala Met Thr 
145                 150                 155                 160 


Ala Thr Glu Lys Ile Leu Phe Leu Ser Ser Ile Ile Pro Phe Asp Cys 
                165                 170                 175     


Leu Leu Thr Val Arg Ala Leu Gly Gly Leu Leu Lys Phe Leu Gly Arg 
            180                 185                 190         


Arg Arg Ile Gly Val Glu Leu Glu Asp Tyr Asn Val Ser Val Pro Ile 
        195                 200                 205             


Leu Gly Phe Lys Lys Phe Met Leu Thr His Leu Val Asn Ile Asp Gln 
    210                 215                 220                 


Asp Thr Tyr Ser Val Leu Gln Ile Phe Lys Ser Glu Ser His Pro Ser 
225                 230                 235                 240 


Val Tyr Lys Val Ala Ser Gly Leu Lys Glu Gly Leu Ser Leu Phe Gly 
                245                 250                 255     


Ile Leu Asn Arg Cys His Cys Lys Trp Gly Glu Lys Leu Leu Arg Leu 
            260                 265                 270         


Trp Phe Thr Arg Pro Thr His Asp Leu Gly Glu Leu Ser Ser Arg Leu 
        275                 280                 285             


Asp Val Ile Gln Phe Phe Leu Leu Pro Gln Asn Leu Asp Met Ala Gln 
    290                 295                 300                 


Met Leu His Arg Leu Leu Gly His Ile Lys Asn Val Pro Leu Ile Leu 
305                 310                 315                 320 


Lys Arg Met Lys Leu Ser His Thr Lys Val Ser Asp Trp Gln Val Leu 
                325                 330                 335     


Tyr Lys Thr Val Tyr Ser Ala Leu Gly Leu Arg Asp Ala Cys Arg Ser 
            340                 345                 350         


Leu Pro Gln Ser Ile Gln Leu Phe Arg Asp Ile Ala Gln Glu Phe Ser 
        355                 360                 365             


Asp Asp Leu His His Ile Ala Ser Leu Ile Gly Lys Val Val Asp Phe 
    370                 375                 380                 


Glu Gly Ser Leu Ala Glu Asn Arg Phe Thr Val Leu Pro Asn Ile Asp 
385                 390                 395                 400 


Pro Glu Ile Asp Glu Lys Lys Arg Arg Leu Met Gly Leu Pro Ser Phe 
                405                 410                 415     


Leu Thr Glu Val Ala Arg Lys Glu Leu Glu Asn Leu Asp Ser Arg Ile 
            420                 425                 430         


Pro Ser Cys Ser Val Ile Tyr Ile Pro Leu Ile Gly Phe Leu Leu Ser 
        435                 440                 445             


Ile Pro Arg Leu Pro Ser Met Val Glu Ala Ser Asp Phe Glu Ile Asn 
    450                 455                 460                 


Gly Leu Asp Phe Met Phe Leu Ser Glu Glu Lys Leu His Tyr Arg Ser 
465                 470                 475                 480 


Ala Arg Thr Lys Glu Leu Asp Ala Leu Leu Gly Asp Leu His Cys Glu 
                485                 490                 495     


Ile Arg Asp Gln Glu Thr Leu Leu Met Tyr Gln Leu Gln Cys Gln Val 
            500                 505                 510         


Leu Ala Arg Ala Ala Val Leu Thr Arg Val Leu Asp Leu Ala Ser Arg 
        515                 520                 525             


Leu Asp Val Leu Leu Ala Leu Ala Ser Ala Ala Arg Asp Tyr Gly Tyr 
    530                 535                 540                 


Ser Arg Pro Arg Tyr Ser Pro Gln Val Leu Gly Val Arg Ile Gln Asn 
545                 550                 555                 560 


Gly Arg His Pro Leu Met Glu Leu Cys Ala Arg Thr Phe Val Pro Asn 
                565                 570                 575     


Ser Thr Glu Cys Gly Gly Asp Lys Gly Arg Val Lys Val Ile Thr Gly 
            580                 585                 590         


Pro Asn Ser Ser Gly Lys Ser Ile Tyr Leu Lys Gln Leu Arg Ile His 
        595                 600                 605             


Leu Pro Trp Pro Leu His Leu His Asp Arg Pro Gln Pro Gly Gly Glu 
    610                 615                 620                 


Ser Ser Glu Gln Cys His Cys Thr Val Ala Gly Pro Tyr 
625                 630                 635         


<210>  8978
<211>  508
<212>  PRT
<213>  Homo Sapiens

<400>  8978

Met Trp Pro Val Leu Leu Phe Val Phe Leu Ser Gln Thr Val Tyr Ser 
1               5                   10                  15      


Ala Leu Gly Leu Arg Asp Ala Cys Arg Ser Leu Pro Gln Ser Ile Gln 
            20                  25                  30          


Leu Phe Arg Asp Ile Ala Gln Glu Phe Ser Asp Asp Leu His His Ile 
        35                  40                  45              


Ala Ser Leu Ile Gly Lys Val Val Asp Phe Glu Gly Ser Leu Ala Glu 
    50                  55                  60                  


Asn Arg Phe Thr Val Leu Pro Asn Ile Asp Pro Glu Ile Asp Glu Lys 
65                  70                  75                  80  


Lys Arg Arg Leu Met Gly Leu Pro Ser Phe Leu Thr Glu Val Ala Arg 
                85                  90                  95      


Lys Glu Leu Glu Asn Leu Asp Ser Arg Ile Pro Ser Cys Ser Val Ile 
            100                 105                 110         


Tyr Ile Pro Leu Ile Gly Phe Leu Leu Ser Ile Pro Arg Leu Pro Ser 
        115                 120                 125             


Met Val Glu Ala Ser Asp Phe Glu Ile Asn Gly Leu Asp Phe Met Phe 
    130                 135                 140                 


Leu Ser Glu Glu Lys Leu His Tyr Arg Ser Ala Arg Thr Lys Glu Leu 
145                 150                 155                 160 


Asp Ala Leu Leu Gly Asp Leu His Cys Glu Ile Arg Asp Gln Glu Thr 
                165                 170                 175     


Leu Leu Met Tyr Gln Leu Gln Cys Gln Val Leu Ala Arg Ala Ala Val 
            180                 185                 190         


Leu Thr Arg Val Leu Asp Leu Ala Ser Arg Leu Asp Val Leu Leu Ala 
        195                 200                 205             


Leu Ala Ser Ala Ala Arg Asp Tyr Gly Tyr Ser Arg Pro Arg Tyr Ser 
    210                 215                 220                 


Pro Gln Val Leu Gly Val Arg Ile Gln Asn Gly Arg His Pro Leu Met 
225                 230                 235                 240 


Glu Leu Cys Ala Arg Thr Phe Val Pro Asn Ser Thr Glu Cys Gly Gly 
                245                 250                 255     


Asp Lys Gly Arg Val Lys Val Ile Thr Gly Pro Asn Ser Ser Gly Lys 
            260                 265                 270         


Ser Ile Tyr Leu Lys Gln Val Gly Leu Ile Thr Phe Met Ala Leu Val 
        275                 280                 285             


Gly Ser Phe Val Pro Ala Glu Glu Ala Glu Ile Gly Ala Val Asp Ala 
    290                 295                 300                 


Ile Phe Thr Arg Ile His Ser Cys Glu Ser Ile Ser Leu Gly Leu Ser 
305                 310                 315                 320 


Thr Phe Met Ile Asp Leu Asn Gln Val Ala Lys Ala Val Asn Asn Ala 
                325                 330                 335     


Thr Ala Gln Ser Leu Val Leu Ile Asp Glu Phe Gly Lys Gly Thr Asn 
            340                 345                 350         


Thr Val Asp Gly Leu Ala Leu Leu Ala Ala Val Leu Arg His Trp Leu 
        355                 360                 365             


Ala Arg Gly Pro Thr Cys Pro His Ile Phe Val Ala Thr Asn Phe Leu 
    370                 375                 380                 


Ser Leu Val Gln Leu Gln Leu Leu Pro Gln Gly Pro Leu Val Gln Tyr 
385                 390                 395                 400 


Leu Thr Met Glu Thr Cys Glu Asp Gly Asn Asp Leu Val Phe Phe Tyr 
                405                 410                 415     


Gln Val Cys Glu Gly Val Ala Lys Ala Ser His Ala Ser His Thr Ala 
            420                 425                 430         


Ala Gln Ala Gly Leu Pro Asp Lys Leu Val Ala Arg Gly Lys Glu Val 
        435                 440                 445             


Ser Asp Leu Ile Arg Ser Gly Lys Pro Ile Lys Pro Val Lys Asp Leu 
    450                 455                 460                 


Leu Lys Lys Asn Gln Met Glu Asn Cys Gln Thr Leu Val Asp Lys Phe 
465                 470                 475                 480 


Met Lys Leu Asp Leu Glu Asp Pro Asn Leu Asp Leu Asn Val Phe Met 
                485                 490                 495     


Ser Gln Glu Val Leu Pro Ala Ala Thr Ser Ile Leu 
            500                 505             


<210>  8979
<211>  156
<212>  PRT
<213>  Homo Sapiens

<400>  8979

Thr Ala Gln Ser Leu Val Leu Ile Asp Glu Phe Gly Lys Gly Thr Asn 
1               5                   10                  15      


Thr Val Asp Gly Leu Ala Leu Leu Ala Ala Val Leu Arg His Trp Leu 
            20                  25                  30          


Ala Arg Gly Pro Thr Cys Pro His Ile Phe Val Ala Thr Asn Phe Leu 
        35                  40                  45              


Ser Leu Val Gln Leu Gln Leu Leu Pro Gln Gly Pro Leu Val Gln Tyr 
    50                  55                  60                  


Leu Val Cys Glu Gly Val Ala Lys Ala Ser His Ala Ser His Thr Ala 
65                  70                  75                  80  


Ala Gln Ala Gly Leu Pro Asp Lys Leu Val Ala Arg Gly Lys Glu Val 
                85                  90                  95      


Ser Asp Leu Ile Arg Ser Gly Lys Pro Ile Lys Pro Val Lys Asp Leu 
            100                 105                 110         


Leu Lys Lys Asn Gln Met Glu Asn Cys Gln Thr Leu Val Asp Lys Phe 
        115                 120                 125             


Met Lys Leu Asp Leu Glu Asp Pro Asn Leu Asp Leu Asn Val Phe Met 
    130                 135                 140                 


Ser Gln Glu Val Leu Pro Ala Ala Thr Ser Ile Leu 
145                 150                 155     


<210>  8980
<211>  159
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8980

Xaa Asp Ala Pro Asp His Glu Ser Leu Lys Leu Leu Gln Arg Val Leu 
1               5                   10                  15      


Asp Glu Ile Asn Pro Gln Ser Val Val Thr Ser Ala Lys Gln Asp Glu 
            20                  25                  30          


Asn Met Thr Arg Phe Leu Gly Lys Leu Ala Ser Gln Glu His Arg Glu 
        35                  40                  45              


Pro Lys Arg Pro Glu Ile Ile Phe Leu Pro Ser Val Asp Phe Gly Leu 
    50                  55                  60                  


Glu Ile Ser Lys Gln Arg Leu Leu Ser Gly Asn Tyr Ser Phe Ile Pro 
65                  70                  75                  80  


Asp Ala Met Thr Ala Thr Glu Lys Ile Leu Phe Leu Ser Ser Ile Ile 
                85                  90                  95      


Pro Phe Asp Cys Leu Leu Thr Val Arg Ala Leu Gly Gly Leu Leu Lys 
            100                 105                 110         


Phe Leu Gly Arg Arg Arg Ile Gly Val Glu Leu Glu Asp Tyr Asn Val 
        115                 120                 125             


Ser Val Pro Ile Leu Gly Phe Lys Lys Phe Met Leu Thr His Leu Val 
    130                 135                 140                 


Asn Ile Asp Gln Asp Thr Tyr Arg Asn Pro Gln Gln Met Pro Leu 
145                 150                 155                 


<210>  8981
<211>  43
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8981

Xaa Arg Ile Gly Val Glu Leu Glu Asp Tyr Asn Val Ser Val Pro Ile 
1               5                   10                  15      


Leu Gly Phe Lys Lys Phe Met Leu Thr His Leu Val Asn Ile Asp Gln 
            20                  25                  30          


Asp Thr Tyr Arg Asn Pro Gln Gln Met Pro Leu 
        35                  40              


<210>  8982
<211>  170
<212>  PRT
<213>  Homo Sapiens

<400>  8982

Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro 
1               5                   10                  15      


Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 
            20                  25                  30          


Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu 
        35                  40                  45              


Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg 
    50                  55                  60                  


Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu 
65                  70                  75                  80  


Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu 
                85                  90                  95      


Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro 
            100                 105                 110         


Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro 
        115                 120                 125             


Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile 
    130                 135                 140                 


Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln 
145                 150                 155                 160 


Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp 
                165                 170 


<210>  8983
<211>  333
<212>  PRT
<213>  Homo Sapiens

<400>  8983

Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro 
1               5                   10                  15      


Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 
            20                  25                  30          


Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu 
        35                  40                  45              


Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg 
    50                  55                  60                  


Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu 
65                  70                  75                  80  


Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu 
                85                  90                  95      


Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro 
            100                 105                 110         


Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro 
        115                 120                 125             


Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile 
    130                 135                 140                 


Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln 
145                 150                 155                 160 


Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu 
                165                 170                 175     


Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu 
            180                 185                 190         


Pro Gly Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu 
        195                 200                 205             


Gly Ile Val Ala Ala Trp Arg Gln Arg Ser Ser Arg Asp Pro Ser Trp 
    210                 215                 220                 


Arg Gln Pro Glu Arg Thr Ile Leu Arg Pro Arg Phe Arg Arg Glu Val 
225                 230                 235                 240 


Glu Lys Thr Ala Cys Pro Ser Gly Lys Lys Ala Arg Glu Ile Asp Glu 
                245                 250                 255     


Ser Leu Ile Phe Tyr Lys Lys Trp Glu Leu Glu Ala Cys Val Asp Ala 
            260                 265                 270         


Ala Leu Leu Ala Thr Gln Met Asp Arg Val Asn Ala Ile Pro Phe Thr 
        275                 280                 285             


Tyr Glu Gln Leu Asp Val Leu Lys His Lys Leu Asp Glu Leu Tyr Pro 
    290                 295                 300                 


Gln Gly Tyr Pro Glu Ser Val Ile Gln His Leu Gly Tyr Leu Phe Leu 
305                 310                 315                 320 


Lys Met Ser Pro Glu Asp Ile Arg Lys Trp Asn Val Thr 
                325                 330             


<210>  8984
<211>  630
<212>  PRT
<213>  Homo Sapiens

<400>  8984

Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro 
1               5                   10                  15      


Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 
            20                  25                  30          


Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu 
        35                  40                  45              


Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg 
    50                  55                  60                  


Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu 
65                  70                  75                  80  


Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu 
                85                  90                  95      


Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro 
            100                 105                 110         


Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro 
        115                 120                 125             


Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile 
    130                 135                 140                 


Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln 
145                 150                 155                 160 


Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu 
                165                 170                 175     


Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu 
            180                 185                 190         


Pro Gly Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu 
        195                 200                 205             


Val Ser Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg 
    210                 215                 220                 


Ala Ala Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp 
225                 230                 235                 240 


Ser Val Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly 
                245                 250                 255     


Gln Pro Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg 
            260                 265                 270         


Gln Arg Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile 
        275                 280                 285             


Leu Arg Pro Arg Phe Arg Arg Glu Val Glu Lys Thr Ala Cys Pro Ser 
    290                 295                 300                 


Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys 
305                 310                 315                 320 


Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met 
                325                 330                 335     


Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu 
            340                 345                 350         


Lys His Lys Leu Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val 
        355                 360                 365             


Ile Gln His Leu Gly Tyr Leu Phe Leu Lys Met Ser Pro Glu Asp Ile 
    370                 375                 380                 


Arg Lys Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu 
385                 390                 395                 400 


Val Asn Lys Gly His Glu Met Ser Pro Gln Ala Pro Arg Arg Pro Leu 
                405                 410                 415     


Pro Gln Val Ala Thr Leu Ile Asp Arg Phe Val Lys Gly Arg Gly Gln 
            420                 425                 430         


Leu Asp Lys Asp Thr Leu Asp Thr Leu Thr Ala Phe Tyr Pro Gly Tyr 
        435                 440                 445             


Leu Cys Ser Leu Ser Pro Glu Glu Leu Ser Ser Val Pro Pro Ser Ser 
    450                 455                 460                 


Ile Trp Ala Val Arg Pro Gln Asp Leu Asp Thr Cys Asp Pro Arg Gln 
465                 470                 475                 480 


Leu Asp Val Leu Tyr Pro Lys Ala Arg Leu Ala Phe Gln Asn Met Asn 
                485                 490                 495     


Gly Ser Glu Tyr Phe Val Lys Ile Gln Ser Phe Leu Gly Gly Ala Pro 
            500                 505                 510         


Thr Glu Asp Leu Lys Ala Leu Ser Gln Gln Asn Val Ser Met Asp Leu 
        515                 520                 525             


Ala Thr Phe Met Lys Leu Arg Thr Asp Ala Val Leu Pro Leu Thr Val 
    530                 535                 540                 


Ala Glu Val Gln Lys Leu Leu Gly Pro His Val Glu Gly Leu Lys Ala 
545                 550                 555                 560 


Glu Glu Arg His Arg Pro Val Arg Asp Trp Ile Leu Arg Gln Arg Gln 
                565                 570                 575     


Asp Asp Leu Asp Thr Leu Gly Leu Gly Leu Gln Gly Gly Ile Pro Asn 
            580                 585                 590         


Gly Tyr Leu Val Leu Asp Leu Ser Met Gln Glu Ala Leu Ser Gly Thr 
        595                 600                 605             


Pro Cys Leu Leu Gly Pro Gly Pro Val Leu Thr Val Leu Ala Leu Leu 
    610                 615                 620                 


Leu Ala Ser Thr Leu Ala 
625                 630 


<210>  8985
<211>  622
<212>  PRT
<213>  Homo Sapiens

<400>  8985

Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro 
1               5                   10                  15      


Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 
            20                  25                  30          


Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu 
        35                  40                  45              


Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg 
    50                  55                  60                  


Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu 
65                  70                  75                  80  


Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu 
                85                  90                  95      


Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro 
            100                 105                 110         


Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro 
        115                 120                 125             


Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile 
    130                 135                 140                 


Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln 
145                 150                 155                 160 


Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu 
                165                 170                 175     


Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu 
            180                 185                 190         


Pro Gly Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu 
        195                 200                 205             


Val Ser Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg 
    210                 215                 220                 


Ala Ala Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp 
225                 230                 235                 240 


Ser Val Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly 
                245                 250                 255     


Gln Pro Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg 
            260                 265                 270         


Gln Arg Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile 
        275                 280                 285             


Leu Arg Pro Arg Phe Arg Arg Glu Val Glu Lys Thr Ala Cys Pro Ser 
    290                 295                 300                 


Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys 
305                 310                 315                 320 


Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met 
                325                 330                 335     


Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu 
            340                 345                 350         


Lys His Lys Leu Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val 
        355                 360                 365             


Ile Gln His Leu Gly Tyr Leu Phe Leu Lys Met Ser Pro Glu Asp Ile 
    370                 375                 380                 


Arg Lys Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu 
385                 390                 395                 400 


Val Asn Lys Gly His Glu Met Ser Pro Gln Val Ala Thr Leu Ile Asp 
                405                 410                 415     


Arg Phe Val Lys Gly Arg Gly Gln Leu Asp Lys Asp Thr Leu Asp Thr 
            420                 425                 430         


Leu Thr Ala Phe Tyr Pro Gly Tyr Leu Cys Ser Leu Ser Pro Glu Glu 
        435                 440                 445             


Leu Ser Ser Val Pro Pro Ser Ser Ile Trp Ala Val Arg Pro Gln Asp 
    450                 455                 460                 


Leu Asp Thr Cys Asp Pro Arg Gln Leu Asp Val Leu Tyr Pro Lys Ala 
465                 470                 475                 480 


Arg Leu Ala Phe Gln Asn Met Asn Gly Ser Glu Tyr Phe Val Lys Ile 
                485                 490                 495     


Gln Ser Phe Leu Gly Gly Ala Pro Thr Glu Asp Leu Lys Ala Leu Ser 
            500                 505                 510         


Gln Gln Asn Val Ser Met Asp Leu Ala Thr Phe Met Lys Leu Arg Thr 
        515                 520                 525             


Asp Ala Val Leu Pro Leu Thr Val Ala Glu Val Gln Lys Leu Leu Gly 
    530                 535                 540                 


Pro His Val Glu Gly Leu Lys Ala Glu Glu Arg His Arg Pro Val Arg 
545                 550                 555                 560 


Asp Trp Ile Leu Arg Gln Arg Gln Asp Asp Leu Asp Thr Leu Gly Leu 
                565                 570                 575     


Gly Leu Gln Gly Gly Ile Pro Asn Gly Tyr Leu Val Leu Asp Leu Ser 
            580                 585                 590         


Met Gln Glu Ala Leu Ser Gly Thr Pro Cys Leu Leu Gly Pro Gly Pro 
        595                 600                 605             


Val Leu Thr Val Leu Ala Leu Leu Leu Ala Ser Thr Leu Ala 
    610                 615                 620         


<210>  8986
<211>  622
<212>  PRT
<213>  Homo Sapiens

<400>  8986

Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro 
1               5                   10                  15      


Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 
            20                  25                  30          


Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu 
        35                  40                  45              


Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg 
    50                  55                  60                  


Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu 
65                  70                  75                  80  


Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu 
                85                  90                  95      


Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro 
            100                 105                 110         


Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro 
        115                 120                 125             


Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile 
    130                 135                 140                 


Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln 
145                 150                 155                 160 


Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu 
                165                 170                 175     


Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu 
            180                 185                 190         


Pro Gly Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu 
        195                 200                 205             


Val Ser Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg 
    210                 215                 220                 


Ala Ala Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp 
225                 230                 235                 240 


Ser Val Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly 
                245                 250                 255     


Gln Pro Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg 
            260                 265                 270         


Gln Arg Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile 
        275                 280                 285             


Leu Arg Pro Arg Phe Arg Arg Glu Val Glu Lys Thr Ala Cys Pro Ser 
    290                 295                 300                 


Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys 
305                 310                 315                 320 


Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met 
                325                 330                 335     


Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu 
            340                 345                 350         


Lys His Lys Leu Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val 
        355                 360                 365             


Ile Gln His Leu Gly Tyr Leu Phe Leu Lys Met Ser Pro Glu Asp Ile 
    370                 375                 380                 


Arg Lys Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu 
385                 390                 395                 400 


Val Asn Lys Gly His Glu Met Ser Pro Gln Val Ala Thr Leu Ile Asp 
                405                 410                 415     


Arg Phe Val Lys Gly Arg Gly Gln Leu Asp Lys Asp Thr Leu Asp Thr 
            420                 425                 430         


Leu Thr Ala Phe Tyr Pro Gly Tyr Leu Cys Ser Leu Ser Pro Glu Glu 
        435                 440                 445             


Leu Ser Ser Val Pro Pro Ser Ser Ile Trp Ala Val Arg Pro Gln Asp 
    450                 455                 460                 


Leu Asp Thr Cys Asp Pro Arg Gln Leu Asp Val Leu Tyr Pro Lys Ala 
465                 470                 475                 480 


Arg Leu Ala Phe Gln Asn Met Asn Gly Ser Glu Tyr Phe Val Lys Ile 
                485                 490                 495     


Gln Ser Phe Leu Gly Gly Ala Pro Thr Glu Asp Leu Lys Ala Leu Ser 
            500                 505                 510         


Gln Gln Asn Val Ser Met Asp Leu Ala Thr Phe Met Lys Leu Arg Thr 
        515                 520                 525             


Asp Ala Val Leu Pro Leu Thr Val Ala Glu Val Gln Lys Leu Leu Gly 
    530                 535                 540                 


Pro His Val Glu Gly Leu Lys Ala Glu Glu Arg His Arg Pro Val Arg 
545                 550                 555                 560 


Asp Trp Ile Leu Arg Gln Arg Gln Asp Asp Leu Asp Thr Leu Gly Leu 
                565                 570                 575     


Gly Leu Gln Gly Gly Ile Pro Asn Gly Tyr Leu Val Leu Asp Leu Ser 
            580                 585                 590         


Met Gln Glu Ala Leu Ser Gly Thr Pro Cys Leu Leu Gly Pro Gly Pro 
        595                 600                 605             


Val Leu Thr Val Leu Ala Leu Leu Leu Ala Ser Thr Leu Ala 
    610                 615                 620         


<210>  8987
<211>  622
<212>  PRT
<213>  Homo Sapiens

<400>  8987

Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro 
1               5                   10                  15      


Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 
            20                  25                  30          


Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu 
        35                  40                  45              


Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg 
    50                  55                  60                  


Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu 
65                  70                  75                  80  


Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu 
                85                  90                  95      


Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro 
            100                 105                 110         


Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro 
        115                 120                 125             


Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile 
    130                 135                 140                 


Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln 
145                 150                 155                 160 


Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu 
                165                 170                 175     


Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu 
            180                 185                 190         


Pro Gly Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu 
        195                 200                 205             


Val Ser Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg 
    210                 215                 220                 


Ala Ala Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp 
225                 230                 235                 240 


Ser Val Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly 
                245                 250                 255     


Gln Pro Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg 
            260                 265                 270         


Gln Arg Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile 
        275                 280                 285             


Leu Arg Pro Arg Phe Arg Arg Glu Val Glu Lys Thr Ala Cys Pro Ser 
    290                 295                 300                 


Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys 
305                 310                 315                 320 


Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met 
                325                 330                 335     


Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu 
            340                 345                 350         


Lys His Lys Leu Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val 
        355                 360                 365             


Ile Gln His Leu Gly Tyr Leu Phe Leu Lys Met Ser Pro Glu Asp Ile 
    370                 375                 380                 


Arg Lys Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu 
385                 390                 395                 400 


Val Asn Lys Gly His Glu Met Ser Pro Gln Val Ala Thr Leu Ile Asp 
                405                 410                 415     


Arg Phe Val Lys Gly Arg Gly Gln Leu Asp Lys Asp Thr Leu Asp Thr 
            420                 425                 430         


Leu Thr Ala Phe Tyr Pro Gly Tyr Leu Cys Ser Leu Ser Pro Glu Glu 
        435                 440                 445             


Leu Ser Ser Val Pro Pro Ser Ser Ile Trp Ala Val Arg Pro Gln Asp 
    450                 455                 460                 


Leu Asp Thr Cys Asp Pro Arg Gln Leu Asp Val Leu Tyr Pro Lys Ala 
465                 470                 475                 480 


Arg Leu Ala Phe Gln Asn Met Asn Gly Ser Glu Tyr Phe Val Lys Ile 
                485                 490                 495     


Gln Ser Phe Leu Gly Gly Ala Pro Thr Glu Asp Leu Lys Ala Leu Ser 
            500                 505                 510         


Gln Gln Asn Val Ser Met Asp Leu Ala Thr Phe Met Lys Leu Arg Thr 
        515                 520                 525             


Asp Ala Val Leu Pro Leu Thr Val Ala Glu Val Gln Lys Leu Leu Gly 
    530                 535                 540                 


Pro His Val Glu Gly Leu Lys Ala Glu Glu Arg His Arg Pro Val Arg 
545                 550                 555                 560 


Asp Trp Ile Leu Arg Gln Arg Gln Asp Asp Leu Asp Thr Leu Gly Leu 
                565                 570                 575     


Gly Leu Gln Gly Gly Ile Pro Asn Gly Tyr Leu Val Leu Asp Leu Ser 
            580                 585                 590         


Met Gln Glu Ala Leu Ser Gly Thr Pro Cys Leu Leu Gly Pro Gly Pro 
        595                 600                 605             


Val Leu Thr Val Leu Ala Leu Leu Leu Ala Ser Thr Leu Ala 
    610                 615                 620         


<210>  8988
<211>  398
<212>  PRT
<213>  Homo Sapiens

<400>  8988

Val Glu Lys Thr Ala Cys Pro Ser Gly Lys Lys Ala Arg Glu Ile Asp 
1               5                   10                  15      


Glu Ser Leu Ile Phe Tyr Lys Lys Trp Glu Leu Glu Ala Cys Val Asp 
            20                  25                  30          


Ala Ala Leu Leu Ala Thr Gln Met Asp Arg Val Asn Ala Ile Pro Phe 
        35                  40                  45              


Thr Tyr Glu Gln Leu Asp Val Leu Lys His Lys Leu Asp Glu Leu Tyr 
    50                  55                  60                  


Pro Gln Gly Tyr Pro Glu Ser Val Ile Gln His Leu Gly Tyr Leu Phe 
65                  70                  75                  80  


Leu Lys Met Ser Pro Glu Asp Ile Arg Lys Trp Asn Val Thr Ser Leu 
                85                  90                  95      


Glu Thr Leu Lys Ala Leu Leu Glu Val Asn Lys Gly His Glu Met Ser 
            100                 105                 110         


Pro Gln Val Ala Thr Leu Ile Asp Arg Phe Val Lys Gly Arg Gly Gln 
        115                 120                 125             


Leu Asp Lys Asp Thr Leu Asp Thr Leu Thr Ala Phe Tyr Pro Gly Tyr 
    130                 135                 140                 


Leu Cys Ser Leu Ser Pro Glu Glu Leu Ser Ser Val Pro Pro Ser Ser 
145                 150                 155                 160 


Ile Trp Ala Val Arg Pro Gln Asp Leu Asp Thr Cys Asp Pro Arg Gln 
                165                 170                 175     


Leu Asp Val Leu Tyr Pro Lys Ala Arg Leu Ala Phe Gln Asn Met Asn 
            180                 185                 190         


Gly Ser Glu Tyr Phe Val Lys Ile Gln Ser Phe Leu Gly Gly Ala Pro 
        195                 200                 205             


Thr Glu Asp Leu Lys Ala Leu Ser Gln Gln Asn Val Ser Met Asp Leu 
    210                 215                 220                 


Ala Thr Phe Met Lys Leu Arg Thr Asp Ala Val Leu Pro Leu Thr Val 
225                 230                 235                 240 


Ala Glu Val Gln Lys Leu Leu Gly Pro His Val Glu Gly Leu Lys Ala 
                245                 250                 255     


Glu Glu Arg His Arg Pro Val Arg Asp Trp Ile Leu Arg Gln Arg Gln 
            260                 265                 270         


Asp Asp Leu Asp Thr Leu Gly Leu Gly Leu Gln Gly Gly Ile Pro Asn 
        275                 280                 285             


Gly Tyr Leu Val Leu Asp Leu Ser Met Gln Gly Gly Arg Gly Gly Gln 
    290                 295                 300                 


Ala Arg Ala Gly Gly Arg Ala Gly Gly Val Glu Val Gly Ala Leu Ser 
305                 310                 315                 320 


His Pro Ser Leu Cys Arg Gly Pro Leu Gly Asp Ala Leu Pro Pro Arg 
                325                 330                 335     


Thr Trp Thr Cys Ser His Arg Pro Gly Thr Ala Pro Ser Leu His Pro 
            340                 345                 350         


Gly Leu Arg Ala Pro Leu Pro Cys Trp Pro Gln Pro Cys Trp Gly Ser 
        355                 360                 365             


Pro Pro Gly Gln Glu Gln Ala Arg Val Val Pro Val Pro Pro Gln Glu 
    370                 375                 380                 


Asn Ser Arg Ser Val Asn Gly Asn Met Pro Pro Ala Asp Thr 
385                 390                 395             


<210>  8989
<211>  334
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8989

Xaa Ser Trp Arg Gln Pro Glu Arg Thr Ile Leu Arg Pro Arg Phe Arg 
1               5                   10                  15      


Arg Glu Val Glu Lys Thr Ala Cys Pro Ser Gly Lys Lys Ala Arg Glu 
            20                  25                  30          


Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys Trp Glu Leu Glu Ala Cys 
        35                  40                  45              


Val Asp Ala Ala Leu Leu Ala Thr Gln Met Asp Arg Val Asn Ala Ile 
    50                  55                  60                  


Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu Lys His Lys Leu Asp Glu 
65                  70                  75                  80  


Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val Ile Gln His Leu Gly Tyr 
                85                  90                  95      


Leu Phe Leu Lys Met Ser Pro Glu Asp Ile Arg Lys Trp Asn Val Thr 
            100                 105                 110         


Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu Val Asn Lys Gly His Glu 
        115                 120                 125             


Met Ser Pro Gln Val Ala Thr Leu Ile Asp Arg Phe Val Lys Gly Arg 
    130                 135                 140                 


Gly Gln Leu Asp Lys Asp Thr Leu Asp Thr Leu Thr Ala Phe Tyr Pro 
145                 150                 155                 160 


Gly Tyr Leu Cys Ser Leu Ser Pro Glu Glu Leu Ser Ser Val Pro Pro 
                165                 170                 175     


Ser Ser Ile Trp Ala Val Arg Pro Gln Asp Leu Asp Thr Cys Asp Pro 
            180                 185                 190         


Arg Gln Leu Asp Val Leu Tyr Pro Lys Ala Arg Leu Ala Phe Gln Asn 
        195                 200                 205             


Met Asn Gly Ser Glu Tyr Phe Val Lys Ile Gln Ser Phe Leu Gly Gly 
    210                 215                 220                 


Ala Pro Thr Glu Asp Leu Lys Ala Leu Ser Gln Gln Asn Val Ser Met 
225                 230                 235                 240 


Asp Leu Ala Thr Phe Met Lys Leu Arg Thr Asp Ala Val Leu Pro Leu 
                245                 250                 255     


Thr Val Ala Glu Val Gln Lys Leu Leu Gly Pro His Val Glu Gly Leu 
            260                 265                 270         


Lys Ala Glu Glu Arg His Arg Pro Val Arg Asp Trp Ile Leu Arg Gln 
        275                 280                 285             


Arg Gln Asp Asp Leu Asp Thr Leu Gly Leu Gly Leu Gln Gly Gly Ile 
    290                 295                 300                 


Pro Asn Gly Tyr Leu Val Leu Asp Leu Ser Met Gln Gly Pro Gly Pro 
305                 310                 315                 320 


Val Leu Thr Val Leu Ala Leu Leu Leu Ala Ser Thr Leu Ala 
                325                 330                 


<210>  8990
<211>  114
<212>  PRT
<213>  Homo Sapiens

<400>  8990

Met Asn Val Leu Leu Gly Ser Val Val Ile Phe Ala Thr Phe Val Thr 
1               5                   10                  15      


Leu Cys Asn Ala Ser Cys Tyr Phe Ile Pro Asn Glu Gly Val Pro Gly 
            20                  25                  30          


Asp Ser Thr Arg Lys Cys Met Asp Leu Lys Gly Asn Lys His Pro Ile 
        35                  40                  45              


Asn Ser Glu Trp Gln Thr Asp Asn Cys Glu Thr Cys Thr Cys Tyr Glu 
    50                  55                  60                  


Thr Glu Ile Ser Cys Cys Thr Leu Val Ser Thr Pro Val Gly Tyr Asp 
65                  70                  75                  80  


Lys Asp Asn Cys Gln Arg Ile Phe Lys Lys Glu Asp Cys Lys Tyr Ile 
                85                  90                  95      


Val Val Glu Lys Lys Asp Pro Lys Lys Thr Cys Ser Val Ser Glu Trp 
            100                 105                 110         


Ile Ile 
        


<210>  8991
<211>  77
<212>  PRT
<213>  Homo Sapiens

<400>  8991

Met Asn Val Leu Leu Gly Ser Val Val Ile Phe Ala Thr Phe Val Thr 
1               5                   10                  15      


Leu Cys Asn Ala Ser Cys Tyr Phe Ile Pro Asn Glu Gly Val Pro Gly 
            20                  25                  30          


Asp Ser Thr Arg Met Phe Leu His Leu Trp Val Met Thr Lys Thr Thr 
        35                  40                  45              


Ala Lys Glu Ser Ser Arg Arg Arg Thr Ala Ser Ile Ser Trp Trp Arg 
    50                  55                  60                  


Arg Arg Thr Gln Lys Arg Pro Val Leu Ser Val Asn Gly 
65                  70                  75          


<210>  8992
<211>  59
<212>  PRT
<213>  Homo Sapiens

<400>  8992

Met Ala Val Phe Gly Met Gly Cys Phe Trp Gly Ala Glu Arg Lys Phe 
1               5                   10                  15      


Trp Val Leu Lys Gly Val Tyr Ser Thr Gln Val Gly Phe Ala Gly Gly 
            20                  25                  30          


Tyr Thr Ser Asn Pro Thr Tyr Lys Glu Val Cys Ser Asp Val Gln Asn 
        35                  40                  45              


Asn Ser Met Phe Ile Ser Leu Phe Lys Ser Phe 
    50                  55                  


<210>  8993
<211>  82
<212>  PRT
<213>  Homo Sapiens

<400>  8993

Met Ala Val Phe Gly Met Gly Cys Phe Trp Gly Ala Glu Arg Lys Phe 
1               5                   10                  15      


Trp Val Leu Lys Gly Val Tyr Ser Thr Gln Val Gly Phe Ala Gly Gly 
            20                  25                  30          


Tyr Thr Ser Asn Pro Thr Tyr Lys Glu Val Cys Ser Glu Lys Thr Gly 
        35                  40                  45              


His Ala Glu Val Val Arg Val Val Tyr Gln Pro Glu His Met Ser Phe 
    50                  55                  60                  


Glu Glu Leu Leu Lys Val Phe Trp Glu Asn His Asp Pro Thr Gln Gly 
65                  70                  75                  80  


Met Arg 
        


<210>  8994
<211>  169
<212>  PRT
<213>  Homo Sapiens

<400>  8994

Met Ala Val Phe Gly Met Gly Cys Phe Trp Gly Ala Glu Arg Lys Phe 
1               5                   10                  15      


Trp Val Leu Lys Gly Val Tyr Ser Thr Gln Val Gly Phe Ala Gly Gly 
            20                  25                  30          


Tyr Thr Ser Asn Pro Thr Tyr Lys Glu Val Cys Ser Glu Lys Thr Gly 
        35                  40                  45              


His Ala Glu Val Val Arg Val Val Tyr Gln Pro Glu His Met Ser Phe 
    50                  55                  60                  


Glu Glu Leu Leu Lys Val Phe Trp Glu Asn His Asp Pro Thr Gln Gly 
65                  70                  75                  80  


Met Arg Gln Gly Asn Asp His Gly Thr Gln Tyr Arg Ser Ala Ile Tyr 
                85                  90                  95      


Pro Thr Ser Ala Lys Gln Met Glu Ala Ala Leu Ser Ser Lys Glu Asn 
            100                 105                 110         


Tyr Gln Lys Val Leu Ser Glu His Gly Phe Gly Pro Ile Thr Thr Asp 
        115                 120                 125             


Ile Arg Glu Gly Gln Thr Phe Tyr Tyr Ala Glu Asp Tyr His Gln Gln 
    130                 135                 140                 


Tyr Leu Ser Lys Asn Pro Asn Gly Tyr Cys Gly Leu Gly Gly Thr Gly 
145                 150                 155                 160 


Val Ser Cys Pro Val Gly Ile Lys Lys 
                165                 


<210>  8995
<211>  192
<212>  PRT
<213>  Homo Sapiens

<400>  8995

Met Cys Ser Glu Pro Lys His His Val Asn Gly Asn Arg Thr Val Glu 
1               5                   10                  15      


Pro Phe Pro Glu Gly Thr Gln Met Ala Val Phe Gly Met Gly Cys Phe 
            20                  25                  30          


Trp Gly Ala Glu Arg Lys Phe Trp Val Leu Lys Gly Val Tyr Ser Thr 
        35                  40                  45              


Gln Val Gly Phe Ala Gly Gly Tyr Thr Ser Asn Pro Thr Tyr Lys Glu 
    50                  55                  60                  


Val Cys Ser Glu Lys Thr Gly His Ala Glu Val Val Arg Val Val Tyr 
65                  70                  75                  80  


Gln Pro Glu His Met Ser Phe Glu Glu Leu Leu Lys Val Phe Trp Glu 
                85                  90                  95      


Asn His Asp Pro Thr Gln Gly Met Arg Gln Gly Asn Asp His Gly Thr 
            100                 105                 110         


Gln Tyr Arg Ser Ala Ile Tyr Pro Thr Ser Ala Lys Gln Met Glu Ala 
        115                 120                 125             


Ala Leu Ser Ser Lys Glu Asn Tyr Gln Lys Val Leu Ser Glu His Gly 
    130                 135                 140                 


Phe Gly Pro Ile Thr Thr Asp Ile Arg Glu Gly Gln Thr Phe Tyr Tyr 
145                 150                 155                 160 


Ala Glu Asp Tyr His Gln Gln Tyr Leu Ser Lys Asn Pro Asn Gly Tyr 
                165                 170                 175     


Cys Gly Leu Gly Gly Thr Gly Val Ser Cys Pro Val Gly Ile Lys Lys 
            180                 185                 190         


<210>  8996
<211>  195
<212>  PRT
<213>  Homo Sapiens

<400>  8996

Met Leu Ser Ala Thr Arg Arg Ala Cys Gln Leu Leu Leu Leu His Ser 
1               5                   10                  15      


Leu Phe Pro Val Pro Arg Met Gly Asn Ser Ala Ser Asn Ile Val Ser 
            20                  25                  30          


Pro Gln Glu Ala Leu Pro Gly Arg Lys Glu Gln Thr Pro Val Ala Ala 
        35                  40                  45              


Lys His His Val Asn Gly Asn Arg Thr Val Glu Pro Phe Pro Glu Gly 
    50                  55                  60                  


Thr Gln Met Ala Val Phe Glu Lys Thr Gly His Ala Glu Val Val Arg 
65                  70                  75                  80  


Val Val Tyr Gln Pro Glu His Met Ser Phe Glu Glu Leu Leu Lys Val 
                85                  90                  95      


Phe Trp Glu Asn His Asp Pro Thr Gln Gly Met Arg Gln Gly Asn Asp 
            100                 105                 110         


His Gly Thr Gln Tyr Arg Ser Ala Ile Tyr Pro Thr Ser Ala Lys Gln 
        115                 120                 125             


Met Glu Ala Ala Leu Ser Ser Lys Glu Asn Tyr Gln Lys Val Leu Ser 
    130                 135                 140                 


Glu His Gly Phe Gly Pro Ile Thr Thr Asp Ile Arg Glu Gly Gln Thr 
145                 150                 155                 160 


Phe Tyr Tyr Ala Glu Asp Tyr His Gln Gln Tyr Leu Ser Lys Asn Pro 
                165                 170                 175     


Asn Gly Tyr Cys Gly Leu Gly Gly Thr Gly Val Ser Cys Pro Val Gly 
            180                 185                 190         


Ile Lys Lys 
        195 


<210>  8997
<211>  213
<212>  PRT
<213>  Homo Sapiens

<400>  8997

Met Leu Ser Ala Thr Arg Arg Ala Cys Gln Leu Leu Leu Leu His Ser 
1               5                   10                  15      


Leu Phe Pro Val Pro Arg Met Gly Asn Ser Ala Ser Asn Ile Val Ser 
            20                  25                  30          


Pro Gln Glu Ala Leu Pro Gly Arg Lys Glu Gln Thr Pro Val Ala Ala 
        35                  40                  45              


Lys His His Val Asn Gly Asn Arg Thr Val Glu Pro Phe Pro Glu Gly 
    50                  55                  60                  


Thr Gln Met Ala Val Phe Gly Met Gly Cys Phe Trp Gly Ala Glu Arg 
65                  70                  75                  80  


Lys Phe Trp Val Leu Lys Gly Val Tyr Ser Thr Gln Val Gly Phe Ala 
                85                  90                  95      


Gly Gly Tyr Thr Ser Asn Pro Thr Tyr Lys Glu Val Cys Ser Glu Lys 
            100                 105                 110         


Thr Gly His Ala Glu Val Val Arg Val Val Tyr Gln Pro Glu His Met 
        115                 120                 125             


Ser Phe Glu Glu Leu Leu Lys Val Phe Trp Glu Asn His Asp Pro Thr 
    130                 135                 140                 


Gln Gly Met Arg Gln Gly Asn Asp His Gly Thr Gln Tyr Arg Ser Ala 
145                 150                 155                 160 


Ile Tyr Pro Thr Ser Ala Lys Gln Met Glu Ala Ala Leu Ser Ser Lys 
                165                 170                 175     


Glu Asn Tyr Gln Lys Leu Val Leu Pro Cys Ser Ser Ser Ala Met Leu 
            180                 185                 190         


Gly Leu Thr Ala Ala Ser Ser Ala Gln Leu Ala Trp Val Gln Pro Ser 
        195                 200                 205             


Ser Arg Lys His Tyr 
    210             


<210>  8998
<211>  235
<212>  PRT
<213>  Homo Sapiens

<400>  8998

Met Leu Ser Ala Thr Arg Arg Ala Cys Gln Leu Leu Leu Leu His Ser 
1               5                   10                  15      


Leu Phe Pro Val Pro Arg Met Gly Asn Ser Ala Ser Asn Ile Val Ser 
            20                  25                  30          


Pro Gln Glu Ala Leu Pro Gly Arg Lys Glu Gln Thr Pro Val Ala Ala 
        35                  40                  45              


Lys His His Val Asn Gly Asn Arg Thr Val Glu Pro Phe Pro Glu Gly 
    50                  55                  60                  


Thr Gln Met Ala Val Phe Gly Met Gly Cys Phe Trp Gly Ala Glu Arg 
65                  70                  75                  80  


Lys Phe Trp Val Leu Lys Gly Val Tyr Ser Thr Gln Val Gly Phe Ala 
                85                  90                  95      


Gly Gly Tyr Thr Ser Asn Pro Thr Tyr Lys Glu Val Cys Ser Glu Lys 
            100                 105                 110         


Thr Gly His Ala Glu Val Val Arg Val Val Tyr Gln Pro Glu His Met 
        115                 120                 125             


Ser Phe Glu Glu Leu Leu Lys Val Phe Trp Glu Asn His Asp Pro Thr 
    130                 135                 140                 


Gln Gly Met Arg Gln Gly Asn Asp His Gly Thr Gln Tyr Arg Ser Ala 
145                 150                 155                 160 


Ile Tyr Pro Thr Ser Ala Lys Gln Met Glu Ala Ala Leu Ser Ser Lys 
                165                 170                 175     


Glu Asn Tyr Gln Lys Val Leu Ser Glu His Gly Phe Gly Pro Ile Thr 
            180                 185                 190         


Thr Asp Ile Arg Glu Gly Gln Thr Phe Tyr Tyr Ala Glu Asp Tyr His 
        195                 200                 205             


Gln Gln Tyr Leu Ser Lys Asn Pro Asn Gly Tyr Cys Gly Leu Gly Gly 
    210                 215                 220                 


Thr Gly Val Ser Cys Pro Val Gly Ile Lys Lys 
225                 230                 235 


<210>  8999
<211>  91
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  8999

Xaa Lys Thr Gly His Ala Glu Val Val Arg Val Val Tyr Gln Pro Glu 
1               5                   10                  15      


His Met Ser Phe Glu Glu Leu Leu Lys Val Phe Trp Glu Asn His Asp 
            20                  25                  30          


Pro Thr Gln Gly Met Arg Gln Gly Asn Asp His Gly Thr Gln Tyr Arg 
        35                  40                  45              


Ser Ala Ile Tyr Pro Thr Ser Ala Lys Gln Met Glu Ala Ala Leu Ser 
    50                  55                  60                  


Ser Lys Glu Asn Tyr Gln Lys Val Pro Lys His Val His Trp Lys Lys 
65                  70                  75                  80  


Arg Thr Gln Thr Gly Leu Gln Thr Glu Gly Arg 
                85                  90      


<210>  9000
<211>  182
<212>  PRT
<213>  Homo Sapiens

<400>  9000

Met Ala Arg Leu Leu Trp Leu Leu Arg Gly Leu Thr Leu Gly Thr Ala 
1               5                   10                  15      


Pro Arg Arg Ala Val Arg Gly Gln Ala Gly Gly Gly Gly Pro Gly Thr 
            20                  25                  30          


Gly Pro Gly Leu Gly Glu Ala Gly Ser Leu Ala Thr Cys Glu Leu Pro 
        35                  40                  45              


Leu Ala Lys Ser Glu Trp Gln Lys Lys Leu Thr Pro Glu Gln Phe Tyr 
    50                  55                  60                  


Val Thr Arg Glu Lys Gly Thr Glu Pro Pro Phe Ser Gly Ile Tyr Leu 
65                  70                  75                  80  


Asn Asn Lys Glu Ala Gly Met Tyr His Cys Val Cys Cys Asp Ser Pro 
                85                  90                  95      


Leu Phe Ser Ser Glu Lys Lys Tyr Cys Ser Gly Thr Gly Trp Pro Ser 
            100                 105                 110         


Phe Ser Glu Ala His Gly Thr Ser Gly Ser Asp Glu Ser His Thr Gly 
        115                 120                 125             


Ile Leu Arg Arg Leu Asp Thr Ser Leu Gly Ser Ala Arg Thr Glu Val 
    130                 135                 140                 


Val Cys Lys Gln Cys Glu Ala His Leu Gly His Val Phe Pro Asp Gly 
145                 150                 155                 160 


Pro Gly Pro Asn Gly Gln Arg Phe Cys Ile Asn Ser Val Ala Leu Lys 
                165                 170                 175     


Phe Lys Pro Arg Lys His 
            180         


<210>  9001
<211>  120
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9001

Xaa Ser Leu Ala Thr Cys Glu Leu Pro Leu Ala Lys Ser Glu Trp Gln 
1               5                   10                  15      


Lys Lys Leu Thr Pro Glu Gln Phe Tyr Val Thr Arg Glu Lys Gly Thr 
            20                  25                  30          


Glu Pro Pro Phe Ser Gly Ile Tyr Leu Asn Asn Lys Glu Ala Gly Met 
        35                  40                  45              


Tyr His Cys Val Cys Cys Asp Ser Pro Leu Phe Arg Ser Leu Leu Asp 
    50                  55                  60                  


Ile Gln Lys Glu Val Phe Ser Ile Lys Gly Ser Arg Ser Pro Ser Thr 
65                  70                  75                  80  


Ser Arg Gly Asn Gly Phe Asp Ser Glu Val Leu Arg Lys Ser Thr Ala 
                85                  90                  95      


Leu Ala Leu Gly Gly Leu Arg Phe Pro Arg Leu Met Val Arg Leu Ala 
            100                 105                 110         


Leu Met Lys Ala Thr Gln Gly Ser 
        115                 120 


<210>  9002
<211>  84
<212>  PRT
<213>  Homo Sapiens

<400>  9002

Gly Glu Tyr Thr His His Lys Asp Pro Gly Ile Tyr Lys Cys Val Val 
1               5                   10                  15      


Cys Gly Thr Pro Leu Phe Lys Ser Glu Thr Lys Phe Asp Ser Gly Ser 
            20                  25                  30          


Gly Trp Pro Ser Phe His Asp Val Ile Asn Ser Glu Ala Ile Thr Phe 
        35                  40                  45              


Thr Asp Asp Phe Ser Tyr Gly Met His Arg Val Glu Thr Ser Cys Ser 
    50                  55                  60                  


Gln Gln Glu Gly Pro His Gln Met Leu Pro Leu Asn Leu Gly Phe Pro 
65                  70                  75                  80  


Gly Leu Gln Asn 
                


<210>  9003
<211>  117
<212>  PRT
<213>  Homo Sapiens

<400>  9003

Met Ser Ala Phe Asn Leu Leu His Leu Val Thr Lys Ser Gln Pro Val 
1               5                   10                  15      


Ala Leu Arg Ala Cys Gly Leu Pro Ser Gly Ser Cys Arg Asp Lys Lys 
            20                  25                  30          


Asn Cys Lys Val Val Phe Ser Gln Gln Glu Leu Arg Lys Arg Leu Thr 
        35                  40                  45              


Pro Leu Gln Tyr His Val Thr Gln Glu Lys Gly Thr Glu Ser Ala Phe 
    50                  55                  60                  


Glu Gly Glu Tyr Thr His His Lys Asp Pro Gly Ile Tyr Lys Cys Val 
65                  70                  75                  80  


Val Cys Gly Thr Pro Leu Phe Lys Ser Glu Thr Lys Phe Asp Ser Gly 
                85                  90                  95      


Ser Gly Trp Pro Ser Phe His Asp Val Ile Asn Ser Glu Ala Ile Thr 
            100                 105                 110         


Phe Thr Asp Asp Phe 
        115         


<210>  9004
<211>  164
<212>  PRT
<213>  Homo Sapiens

<400>  9004

Met Ser Ala Phe Asn Leu Leu His Leu Val Thr Lys Ser Gln Pro Val 
1               5                   10                  15      


Ala Leu Arg Ala Cys Gly Leu Pro Ser Gly Ser Cys Arg Asp Lys Lys 
            20                  25                  30          


Asn Cys Lys Val Val Phe Ser Gln Gln Glu Leu Arg Lys Arg Leu Thr 
        35                  40                  45              


Pro Leu Gln Tyr His Val Thr Gln Glu Lys Gly Thr Glu Ser Ala Phe 
    50                  55                  60                  


Glu Gly Glu Tyr Thr His His Lys Asp Pro Gly Ile Tyr Lys Cys Val 
65                  70                  75                  80  


Val Cys Gly Thr Pro Leu Phe Lys Ser Glu Thr Lys Phe Asp Ser Gly 
                85                  90                  95      


Ser Gly Trp Pro Ser Phe His Asp Val Ile Asn Ser Glu Ala Ile Thr 
            100                 105                 110         


Phe Thr Asp Asp Phe Ser Tyr Gly Met His Arg Val Glu Thr Ser Cys 
        115                 120                 125             


Ser Gln Cys Gly Ala His Leu Gly His Ile Phe Asp Asp Gly Pro Arg 
    130                 135                 140                 


Pro Thr Gly Lys Arg Tyr Cys Ile Asn Ser Ala Ala Leu Ser Phe Thr 
145                 150                 155                 160 


Pro Ala Asp Ser 
                


<210>  9005
<211>  185
<212>  PRT
<213>  Homo Sapiens

<400>  9005

Met Ser Ala Phe Asn Leu Leu His Leu Val Thr Lys Ser Gln Pro Val 
1               5                   10                  15      


Ala Leu Arg Ala Cys Gly Leu Pro Ser Gly Ser Cys Arg Asp Lys Lys 
            20                  25                  30          


Asn Cys Lys Val Val Phe Ser Gln Gln Glu Leu Arg Lys Arg Leu Thr 
        35                  40                  45              


Pro Leu Gln Tyr His Val Thr Gln Glu Lys Gly Thr Glu Ser Ala Phe 
    50                  55                  60                  


Glu Gly Glu Tyr Thr His His Lys Asp Pro Gly Ile Tyr Lys Cys Val 
65                  70                  75                  80  


Val Cys Gly Thr Pro Leu Phe Lys Ser Glu Thr Lys Phe Asp Ser Gly 
                85                  90                  95      


Ser Gly Trp Pro Ser Phe His Asp Val Ile Asn Ser Glu Ala Ile Thr 
            100                 105                 110         


Phe Thr Asp Asp Phe Ser Tyr Gly Met His Arg Val Glu Thr Ser Cys 
        115                 120                 125             


Ser Gln Cys Gly Ala His Leu Gly His Ile Phe Asp Asp Gly Pro Arg 
    130                 135                 140                 


Pro Thr Gly Lys Arg Tyr Cys Ile Asn Ser Ala Ala Leu Ser Phe Thr 
145                 150                 155                 160 


Pro Ala Asp Ser Ser Gly Thr Ala Glu Gly Gly Ser Gly Val Ala Ser 
                165                 170                 175     


Pro Ala Gln Ala Asp Lys Ala Glu Leu 
            180                 185 


<210>  9006
<211>  185
<212>  PRT
<213>  Homo Sapiens

<400>  9006

Met Ser Ala Phe Asn Leu Leu His Leu Val Thr Lys Ser Gln Pro Val 
1               5                   10                  15      


Ala Leu Arg Ala Cys Gly Leu Pro Ser Gly Ser Cys Arg Asp Lys Lys 
            20                  25                  30          


Asn Cys Lys Val Val Phe Ser Gln Gln Glu Leu Arg Lys Arg Leu Thr 
        35                  40                  45              


Pro Leu Gln Tyr His Val Thr Gln Glu Lys Gly Thr Glu Ser Ala Phe 
    50                  55                  60                  


Glu Gly Glu Tyr Thr His His Lys Asp Pro Gly Ile Tyr Lys Cys Val 
65                  70                  75                  80  


Val Cys Gly Thr Pro Leu Phe Lys Ser Glu Thr Lys Phe Asp Ser Gly 
                85                  90                  95      


Ser Gly Trp Pro Ser Phe His Asp Val Ile Asn Ser Glu Ala Ile Thr 
            100                 105                 110         


Phe Thr Asp Asp Phe Ser Tyr Gly Met His Arg Val Glu Thr Ser Cys 
        115                 120                 125             


Ser Gln Cys Gly Ala His Leu Gly His Ile Phe Asp Asp Gly Pro Arg 
    130                 135                 140                 


Pro Thr Gly Lys Arg Tyr Cys Ile Asn Ser Ala Ala Leu Ser Phe Thr 
145                 150                 155                 160 


Pro Ala Asp Ser Ser Gly Thr Ala Glu Gly Gly Ser Gly Val Ala Ser 
                165                 170                 175     


Pro Ala Gln Ala Asp Lys Ala Glu Leu 
            180                 185 


<210>  9007
<211>  185
<212>  PRT
<213>  Homo Sapiens

<400>  9007

Met Ser Ala Phe Asn Leu Leu His Leu Val Thr Lys Ser Gln Pro Val 
1               5                   10                  15      


Ala Leu Arg Ala Cys Gly Leu Pro Ser Gly Ser Cys Arg Asp Lys Lys 
            20                  25                  30          


Asn Cys Lys Val Val Phe Ser Gln Gln Glu Leu Arg Lys Arg Leu Thr 
        35                  40                  45              


Pro Leu Gln Tyr His Val Thr Gln Glu Lys Gly Thr Glu Ser Ala Phe 
    50                  55                  60                  


Glu Gly Glu Tyr Thr His His Lys Asp Pro Gly Ile Tyr Lys Cys Val 
65                  70                  75                  80  


Val Cys Gly Thr Pro Leu Phe Lys Ser Glu Thr Lys Phe Asp Ser Gly 
                85                  90                  95      


Ser Gly Trp Pro Ser Phe His Asp Val Ile Asn Ser Glu Ala Ile Thr 
            100                 105                 110         


Phe Thr Asp Asp Phe Ser Tyr Gly Met His Arg Val Glu Thr Ser Cys 
        115                 120                 125             


Ser Gln Cys Gly Ala His Leu Gly His Ile Phe Asp Asp Gly Pro Arg 
    130                 135                 140                 


Pro Thr Gly Lys Arg Tyr Cys Ile Asn Ser Ala Ala Leu Ser Phe Thr 
145                 150                 155                 160 


Pro Ala Asp Ser Ser Gly Thr Ala Glu Gly Gly Ser Gly Val Ala Ser 
                165                 170                 175     


Pro Ala Gln Ala Asp Lys Ala Glu Leu 
            180                 185 


<210>  9008
<211>  185
<212>  PRT
<213>  Homo Sapiens

<400>  9008

Met Ser Ala Phe Asn Leu Leu His Leu Val Thr Lys Ser Gln Pro Val 
1               5                   10                  15      


Ala Leu Arg Ala Cys Gly Leu Pro Ser Gly Ser Cys Arg Asp Lys Lys 
            20                  25                  30          


Asn Cys Lys Val Val Phe Ser Gln Gln Glu Leu Arg Lys Arg Leu Thr 
        35                  40                  45              


Pro Leu Gln Tyr His Val Thr Gln Glu Lys Gly Thr Glu Ser Ala Phe 
    50                  55                  60                  


Glu Gly Glu Tyr Thr His His Lys Asp Pro Gly Ile Tyr Lys Cys Val 
65                  70                  75                  80  


Val Cys Gly Thr Pro Leu Phe Lys Ser Glu Thr Lys Phe Asp Ser Gly 
                85                  90                  95      


Ser Gly Trp Pro Ser Phe His Asp Val Ile Asn Ser Glu Ala Ile Thr 
            100                 105                 110         


Phe Thr Asp Asp Phe Ser Tyr Gly Met His Arg Val Glu Thr Ser Cys 
        115                 120                 125             


Ser Gln Cys Gly Ala His Leu Gly His Ile Phe Asp Asp Gly Pro Arg 
    130                 135                 140                 


Pro Thr Gly Lys Arg Tyr Cys Ile Asn Ser Ala Ala Leu Ser Phe Thr 
145                 150                 155                 160 


Pro Ala Asp Ser Ser Gly Thr Ala Glu Gly Gly Ser Gly Val Ala Ser 
                165                 170                 175     


Pro Ala Gln Ala Asp Lys Ala Glu Leu 
            180                 185 


<210>  9009
<211>  185
<212>  PRT
<213>  Homo Sapiens

<400>  9009

Met Ser Ala Phe Asn Leu Leu His Leu Val Thr Lys Ser Gln Pro Val 
1               5                   10                  15      


Ala Leu Arg Ala Cys Gly Leu Pro Ser Gly Ser Cys Arg Asp Lys Lys 
            20                  25                  30          


Asn Cys Lys Val Val Phe Ser Gln Gln Glu Leu Arg Lys Arg Leu Thr 
        35                  40                  45              


Pro Leu Gln Tyr His Val Thr Gln Glu Lys Gly Thr Glu Ser Ala Phe 
    50                  55                  60                  


Glu Gly Glu Tyr Thr His His Lys Asp Pro Gly Ile Tyr Lys Cys Val 
65                  70                  75                  80  


Val Cys Gly Thr Pro Leu Phe Lys Ser Glu Thr Lys Phe Asp Ser Gly 
                85                  90                  95      


Ser Gly Trp Pro Ser Phe His Asp Val Ile Asn Ser Glu Ala Ile Thr 
            100                 105                 110         


Phe Thr Asp Asp Phe Ser Tyr Gly Met His Arg Val Glu Thr Ser Cys 
        115                 120                 125             


Ser Gln Cys Gly Ala His Leu Gly His Ile Phe Asp Asp Gly Pro Arg 
    130                 135                 140                 


Pro Thr Gly Lys Arg Tyr Cys Ile Asn Ser Ala Ala Leu Ser Phe Thr 
145                 150                 155                 160 


Pro Ala Asp Ser Ser Gly Thr Ala Glu Gly Gly Ser Gly Val Ala Ser 
                165                 170                 175     


Pro Ala Gln Ala Asp Lys Ala Glu Leu 
            180                 185 


<210>  9010
<211>  185
<212>  PRT
<213>  Homo Sapiens

<400>  9010

Met Ser Ala Phe Asn Leu Leu His Leu Val Thr Lys Ser Gln Pro Val 
1               5                   10                  15      


Ala Leu Arg Ala Cys Gly Leu Pro Ser Gly Ser Cys Arg Asp Lys Lys 
            20                  25                  30          


Asn Cys Lys Val Val Phe Ser Gln Gln Glu Leu Arg Lys Arg Leu Thr 
        35                  40                  45              


Pro Leu Gln Tyr His Val Thr Gln Glu Lys Gly Thr Glu Ser Ala Phe 
    50                  55                  60                  


Glu Gly Glu Tyr Thr His His Lys Asp Pro Gly Ile Tyr Lys Cys Val 
65                  70                  75                  80  


Val Cys Gly Thr Pro Leu Phe Lys Ser Glu Thr Lys Phe Asp Ser Gly 
                85                  90                  95      


Ser Gly Trp Pro Ser Phe His Asp Val Ile Asn Ser Glu Ala Ile Thr 
            100                 105                 110         


Phe Thr Asp Asp Phe Ser Tyr Gly Met His Arg Val Glu Thr Ser Cys 
        115                 120                 125             


Ser Gln Cys Gly Ala His Leu Gly His Ile Phe Asp Asp Gly Pro Arg 
    130                 135                 140                 


Pro Thr Gly Lys Arg Tyr Cys Ile Asn Ser Ala Ala Leu Ser Phe Thr 
145                 150                 155                 160 


Pro Ala Asp Ser Ser Gly Thr Ala Glu Gly Gly Ser Gly Val Ala Ser 
                165                 170                 175     


Pro Ala Gln Ala Asp Lys Ala Glu Leu 
            180                 185 


<210>  9011
<211>  44
<212>  PRT
<213>  Homo Sapiens

<400>  9011

Met Ser Pro Arg Arg Thr Leu Pro Arg Pro Leu Ser Leu Cys Leu Ser 
1               5                   10                  15      


Leu Cys Leu Cys Leu Cys Leu Ala Ala Ala Leu Gly Ser Ala Gln Ser 
            20                  25                  30          


Ala Leu Ala Pro Val Leu Cys Phe Ser Phe Cys Trp 
        35                  40                  


<210>  9012
<211>  192
<212>  PRT
<213>  Homo Sapiens

<400>  9012

Met Ser Pro Arg Arg Thr Leu Pro Arg Pro Leu Ser Leu Cys Leu Ser 
1               5                   10                  15      


Leu Cys Leu Cys Leu Cys Leu Ala Ala Ala Leu Gly Ser Ala Gln Ser 
            20                  25                  30          


Gly Ser Cys Arg Asp Lys Lys Asn Cys Lys Val Val Phe Ser Gln Gln 
        35                  40                  45              


Glu Leu Arg Lys Arg Leu Thr Pro Leu Gln Tyr His Val Thr Gln Glu 
    50                  55                  60                  


Lys Gly Thr Glu Ser Ala Phe Glu Gly Glu Tyr Thr His His Lys Asp 
65                  70                  75                  80  


Pro Gly Ile Tyr Lys Cys Val Val Cys Gly Thr Pro Leu Phe Lys Ser 
                85                  90                  95      


Glu Thr Lys Phe Asp Ser Gly Ser Gly Trp Pro Ser Phe His Asp Val 
            100                 105                 110         


Ile Asn Ser Glu Ala Ile Thr Phe Thr Asp Asp Phe Ser Tyr Gly Met 
        115                 120                 125             


His Arg Val Glu Thr Ser Cys Ser Gln Cys Gly Ala His Leu Gly His 
    130                 135                 140                 


Ile Phe Asp Asp Gly Pro Arg Pro Thr Gly Lys Arg Tyr Cys Ile Asn 
145                 150                 155                 160 


Ser Ala Ala Leu Ser Phe Thr Pro Ala Asp Ser Ser Gly Thr Ala Glu 
                165                 170                 175     


Gly Gly Ser Gly Val Ala Ser Pro Ala Gln Ala Asp Lys Ala Glu Leu 
            180                 185                 190         


<210>  9013
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  9013

Met Ser Pro Arg Arg Thr Leu Pro Arg Pro Leu Ser Leu Cys Leu Ser 
1               5                   10                  15      


Leu Cys Leu Cys Leu Cys Leu Ala Ala Ala Leu Gly Ser Ala Gln Ser 
            20                  25                  30          


Gly Ser Cys Arg Asp Lys Lys Asn Cys Lys Val Val Phe Ser Gln Gln 
        35                  40                  45              


Glu Leu Arg Lys Arg Leu Thr Pro Leu Gln Tyr His Val Thr Gln Glu 
    50                  55                  60                  


Lys Gly Thr Glu Ser Ala Phe Glu Gly Glu Tyr Thr His His Lys Asp 
65                  70                  75                  80  


Pro Gly Ile Tyr Lys Cys Val Val Cys Gly Thr Pro Leu Phe Lys Ser 
                85                  90                  95      


Glu Thr Lys Phe Asp Ser Gly Ser Gly Trp Pro Ser Phe His Asp Val 
            100                 105                 110         


Ile Asn Ser Glu Ala Ile Thr Phe Thr Asp Asp Phe Ser Tyr Gly Met 
        115                 120                 125             


His Arg Val Glu Thr Ser Cys Ser Gln Val Ser Ser Ser Phe Leu Lys 
    130                 135                 140                 


Thr Gln Tyr Ile Ala Phe Arg Thr Pro Gly Cys Ala Lys Tyr Ser Asn 
145                 150                 155                 160 


<210>  9014
<211>  117
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9014

Xaa Leu Arg Lys Arg Leu Thr Pro Leu Gln Tyr His Val Thr Gln Glu 
1               5                   10                  15      


Lys Gly Thr Glu Ser Ala Phe Glu Gly Glu Tyr Thr His His Lys Asp 
            20                  25                  30          


Pro Gly Ile Tyr Lys Cys Val Val Cys Gly Thr Pro Leu Phe Lys Ser 
        35                  40                  45              


Glu Thr Lys Phe Asp Ser Gly Ser Gly Trp Pro Ser Phe His Asp Val 
    50                  55                  60                  


Ile Asn Ser Glu Ala Ile Thr Phe Thr Asp Asp Phe Ser Tyr Gly Met 
65                  70                  75                  80  


His Arg Val Glu Thr Ser Cys Ser Gln Gln Glu Gly Pro His Gln Met 
                85                  90                  95      


Leu Pro Leu Asn Leu Gly Phe Pro Gly Leu Gln Asn Cys Glu Pro Ile 
            100                 105                 110         


Asn Phe Tyr Ser Phe 
        115         


<210>  9015
<211>  174
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9015

Xaa Arg Arg Arg Leu Pro Gly Leu Ser Met Ser Pro Arg Arg Thr Leu 
1               5                   10                  15      


Pro Arg Pro Leu Ser Leu Cys Leu Ser Leu Cys Leu Cys Leu Cys Leu 
            20                  25                  30          


Ala Ala Ala Leu Gly Ser Ala Gln Ser Gly Ser Cys Arg Asp Lys Lys 
        35                  40                  45              


Asn Cys Lys Val Val Phe Ser Gln Gln Glu Leu Arg Lys Arg Leu Thr 
    50                  55                  60                  


Pro Leu Gln Tyr His Val Thr Gln Glu Lys Gly Thr Glu Ser Ala Phe 
65                  70                  75                  80  


Glu Gly Glu Tyr Thr His His Lys Asp Pro Gly Ile Tyr Lys Cys Val 
                85                  90                  95      


Val Cys Gly Thr Pro Leu Phe Lys Ser Glu Thr Lys Phe Asp Ser Gly 
            100                 105                 110         


Ser Gly Trp Pro Ser Phe His Asp Val Ile Asn Ser Glu Ala Ile Thr 
        115                 120                 125             


Phe Thr Asp Asp Phe Ser Tyr Gly Met His Arg Val Glu Thr Ser Cys 
    130                 135                 140                 


Ser Gln Gln Glu Gly Pro His Gln Met Leu Pro Leu Asn Leu Gly Phe 
145                 150                 155                 160 


Pro Gly Leu Gln Asn Cys Glu Pro Ile Asn Phe Tyr Ser Phe 
                165                 170                 


<210>  9016
<211>  725
<212>  PRT
<213>  Homo Sapiens

<400>  9016

Met Gly Leu Trp Trp Val Thr Val Gln Pro Pro Ala Arg Arg Met Gly 
1               5                   10                  15      


Trp Leu Pro Leu Leu Leu Leu Leu Thr Gln Cys Leu Gly Val Pro Gly 
            20                  25                  30          


Gln Arg Ser Pro Leu Asn Asp Phe Gln Val Leu Arg Gly Thr Glu Leu 
        35                  40                  45              


Gln His Leu Leu His Ala Val Val Pro Gly Pro Trp Gln Glu Asp Val 
    50                  55                  60                  


Ala Asp Ala Glu Glu Cys Ala Gly Arg Cys Gly Pro Leu Met Asp Cys 
65                  70                  75                  80  


Arg Ala Phe His Tyr Asn Val Ser Ser His Gly Cys Gln Leu Leu Pro 
                85                  90                  95      


Trp Thr Gln His Ser Pro His Thr Arg Leu Arg Arg Ser Gly Arg Cys 
            100                 105                 110         


Asp Leu Phe Gln Lys Lys Asp Tyr Val Arg Thr Cys Ile Met Asn Asn 
        115                 120                 125             


Gly Val Gly Tyr Arg Gly Thr Met Ala Thr Thr Val Gly Gly Leu Pro 
    130                 135                 140                 


Cys Gln Ala Trp Ser His Lys Phe Pro Asn Asp His Lys Tyr Thr Pro 
145                 150                 155                 160 


Thr Leu Arg Asn Gly Leu Glu Glu Asn Phe Cys Arg Asn Pro Asp Gly 
                165                 170                 175     


Asp Pro Gly Gly Pro Trp Cys Tyr Thr Thr Asp Pro Ala Val Arg Phe 
            180                 185                 190         


Gln Ser Cys Gly Ile Lys Ser Cys Arg Glu Ala Ala Cys Val Trp Cys 
        195                 200                 205             


Asn Gly Glu Glu Tyr Arg Gly Ala Val Asp Arg Thr Glu Ser Gly Arg 
    210                 215                 220                 


Glu Cys Gln Arg Trp Asp Leu Gln His Pro His Gln His Pro Phe Glu 
225                 230                 235                 240 


Pro Gly Lys Phe Leu Asp Gln Gly Leu Asp Asp Asn Tyr Cys Arg Asn 
                245                 250                 255     


Pro Asp Gly Ser Glu Arg Pro Trp Cys Tyr Thr Thr Asp Pro Gln Ile 
            260                 265                 270         


Glu Arg Glu Phe Cys Asp Leu Pro Arg Cys Gly Ser Glu Ala Gln Pro 
        275                 280                 285             


Arg Gln Glu Ala Thr Thr Val Ser Cys Phe Arg Gly Lys Gly Glu Gly 
    290                 295                 300                 


Tyr Arg Gly Thr Ala Asn Thr Thr Thr Ala Gly Val Pro Cys Gln Arg 
305                 310                 315                 320 


Trp Asp Ala Gln Ile Pro His Gln His Arg Phe Thr Pro Glu Lys Tyr 
                325                 330                 335     


Ala Cys Lys Asp Leu Arg Glu Asn Phe Cys Arg Asn Pro Asp Gly Ser 
            340                 345                 350         


Glu Ala Pro Trp Cys Phe Thr Leu Arg Pro Gly Met Arg Ala Ala Phe 
        355                 360                 365             


Cys Tyr Gln Ile Arg Arg Cys Thr Asp Asp Val Arg Pro Gln Asp Cys 
    370                 375                 380                 


Tyr His Gly Ala Gly Glu Gln Tyr Arg Gly Thr Val Ser Lys Thr Arg 
385                 390                 395                 400 


Lys Gly Val Gln Cys Gln Arg Trp Ser Ala Glu Thr Pro His Lys Pro 
                405                 410                 415     


Gln Phe Thr Phe Thr Ser Glu Pro His Ala Gln Leu Glu Glu Asn Phe 
            420                 425                 430         


Cys Arg Asn Pro Asp Gly Asp Ser His Gly Pro Trp Cys Tyr Thr Met 
        435                 440                 445             


Asp Pro Arg Thr Pro Phe Asp Tyr Cys Ala Leu Arg Arg Cys Ala Asp 
    450                 455                 460                 


Asp Gln Pro Pro Ser Ile Leu Asp Pro Pro Asp Gln Val Gln Phe Glu 
465                 470                 475                 480 


Lys Cys Gly Lys Arg Val Asp Arg Leu Asp Gln Arg Arg Ser Lys Leu 
                485                 490                 495     


Arg Val Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val Ser Leu 
            500                 505                 510         


Arg Asn Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val Lys Glu 
        515                 520                 525             


Gln Trp Ile Leu Thr Ala Arg Gln Cys Phe Ser Ser Cys His Met Pro 
    530                 535                 540                 


Leu Thr Gly Tyr Glu Val Trp Leu Gly Thr Leu Phe Gln Asn Pro Gln 
545                 550                 555                 560 


His Gly Glu Pro Ser Leu Gln Arg Val Pro Val Ala Lys Met Val Cys 
                565                 570                 575     


Gly Pro Ser Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg Ser Val 
            580                 585                 590         


Thr Leu Asn Gln Arg Val Ala Leu Ile Cys Leu Pro Pro Glu Trp Tyr 
        595                 600                 605             


Val Val Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly Glu Thr 
    610                 615                 620                 


Lys Gly Thr Gly Asn Asp Thr Val Leu Asn Val Ala Leu Leu Asn Val 
625                 630                 635                 640 


Ile Ser Asn Gln Glu Cys Asn Ile Lys His Arg Gly Arg Val Arg Glu 
                645                 650                 655     


Ser Glu Met Cys Thr Glu Gly Leu Leu Ala Pro Val Gly Ala Cys Glu 
            660                 665                 670         


Gly Asp Tyr Gly Gly Pro Leu Ala Cys Phe Thr His Asn Cys Trp Val 
        675                 680                 685             


Leu Glu Gly Ile Ile Ile Pro Asn Arg Val Cys Ala Arg Ser Arg Trp 
    690                 695                 700                 


Pro Ala Val Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile His Lys 
705                 710                 715                 720 


Val Met Arg Leu Gly 
                725 


<210>  9017
<211>  195
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9017

Xaa Ala Gly Pro Ala Phe Leu Arg Gly Val Ser Ser Glu Gly Ala Val 
1               5                   10                  15      


Asp Thr Asp Cys Pro Ala Val Leu Leu Leu Leu Asn Pro Gln His Gly 
            20                  25                  30          


Glu Pro Ser Leu Gln Arg Val Pro Val Ala Lys Met Val Cys Gly Pro 
        35                  40                  45              


Ser Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg Ser Val Thr Leu 
    50                  55                  60                  


Asn Gln Arg Val Ala Leu Ile Cys Leu Pro Pro Glu Trp Tyr Val Val 
65                  70                  75                  80  


Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly Glu Thr Lys Gly 
                85                  90                  95      


Thr Gly Asn Asp Thr Val Leu Asn Val Ala Leu Leu Asn Val Ile Ser 
            100                 105                 110         


Asn Gln Glu Cys Asn Ile Lys His Arg Gly Arg Val Arg Glu Ser Glu 
        115                 120                 125             


Met Cys Thr Glu Gly Leu Leu Ala Pro Val Gly Ala Cys Glu Gly Asp 
    130                 135                 140                 


Tyr Gly Gly Pro Leu Ala Cys Phe Thr His Asn Cys Trp Val Leu Glu 
145                 150                 155                 160 


Gly Ile Ile Ile Pro Asn Arg Val Cys Ala Arg Ser Arg Trp Pro Ala 
                165                 170                 175     


Val Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile His Lys Val Met 
            180                 185                 190         


Arg Leu Gly 
        195 


<210>  9018
<211>  375
<212>  PRT
<213>  Homo Sapiens

<400>  9018

Met Gln Lys Leu Gln Leu Cys Val Tyr Ile Tyr Leu Phe Met Leu Ile 
1               5                   10                  15      


Val Ala Gly Pro Val Asp Leu Asn Glu Asn Ser Glu Gln Lys Glu Asn 
            20                  25                  30          


Val Glu Lys Glu Gly Leu Cys Asn Ala Cys Thr Trp Arg Gln Asn Thr 
        35                  40                  45              


Lys Ser Ser Arg Ile Glu Ala Ile Lys Ile Gln Ile Leu Ser Lys Leu 
    50                  55                  60                  


Arg Leu Glu Thr Ala Pro Asn Ile Ser Lys Asp Val Ile Arg Gln Leu 
65                  70                  75                  80  


Leu Pro Lys Ala Pro Pro Leu Arg Glu Leu Ile Asp Gln Tyr Asp Val 
                85                  90                  95      


Gln Arg Asp Asp Ser Ser Asp Gly Ser Leu Glu Asp Asp Asp Tyr His 
            100                 105                 110         


Ala Thr Thr Glu Thr Ile Ile Thr Met Pro Thr Glu Ser Asp Phe Leu 
        115                 120                 125             


Met Gln Val Asp Gly Lys Pro Lys Cys Cys Phe Phe Lys Phe Ser Ser 
    130                 135                 140                 


Lys Ile Gln Tyr Asn Lys Val Val Lys Ala Gln Leu Trp Ile Tyr Leu 
145                 150                 155                 160 


Arg Pro Val Glu Thr Pro Thr Thr Val Phe Val Gln Ile Leu Arg Leu 
                165                 170                 175     


Ile Lys Pro Met Lys Asp Gly Thr Arg Tyr Thr Gly Ile Arg Ser Leu 
            180                 185                 190         


Lys Leu Asp Met Asn Pro Gly Thr Gly Ile Trp Gln Ser Ile Asp Val 
        195                 200                 205             


Lys Thr Val Leu Gln Asn Trp Leu Lys Gln Pro Glu Ser Asn Leu Gly 
    210                 215                 220                 


Ile Glu Ile Lys Ala Leu Asp Glu Asn Gly His Asp Leu Ala Val Thr 
225                 230                 235                 240 


Phe Pro Gly Pro Gly Glu Asp Gly Leu Asn Pro Phe Leu Glu Val Lys 
                245                 250                 255     


Val Thr Asp Thr Pro Lys Arg Ser Arg Arg Asp Phe Gly Leu Asp Cys 
            260                 265                 270         


Asp Glu His Ser Thr Glu Ser Arg Cys Cys Arg Tyr Pro Leu Thr Val 
        275                 280                 285             


Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile Ile Ala Pro Lys Arg Tyr 
    290                 295                 300                 


Lys Ala Asn Tyr Cys Ser Gly Glu Cys Glu Phe Val Phe Leu Gln Lys 
305                 310                 315                 320 


Tyr Pro His Thr His Leu Val His Gln Ala Asn Pro Arg Gly Ser Ala 
                325                 330                 335     


Gly Pro Cys Cys Thr Pro Thr Lys Met Ser Pro Ile Asn Met Leu Tyr 
            340                 345                 350         


Phe Asn Gly Lys Glu Gln Ile Ile Tyr Gly Lys Ile Pro Ala Met Val 
        355                 360                 365             


Val Asp Arg Cys Gly Cys Ser 
    370                 375 


<210>  9019
<211>  62
<212>  PRT
<213>  Homo Sapiens

<400>  9019

Met Asp Pro Asn Cys Ser Cys Ala Ala Ala Gly Val Ser Cys Thr Cys 
1               5                   10                  15      


Ala Ser Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser Cys Lys Lys 
            20                  25                  30          


Ser Cys Cys Ser Cys Cys Pro Val Gly Cys Ala Lys Cys Ala Gln Gly 
        35                  40                  45              


Cys Ile Cys Lys Gly Ala Ser Glu Lys Cys Ser Cys Cys Ala 
    50                  55                  60          


<210>  9020
<211>  39
<212>  PRT
<213>  Homo Sapiens

<400>  9020

Met Asp Pro Asn Cys Ser Cys Ala Ala Gly Cys Cys Ser Cys Cys Pro 
1               5                   10                  15      


Val Gly Cys Ala Lys Cys Ala Gln Gly Cys Ile Cys Lys Gly Ala Ser 
            20                  25                  30          


Glu Lys Cys Ser Cys Cys Ala 
        35                  


<210>  9021
<211>  61
<212>  PRT
<213>  Homo Sapiens

<400>  9021

Met Asp Pro Asn Cys Ser Cys Ala Ala Gly Val Ser Cys Thr Cys Ala 
1               5                   10                  15      


Ser Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser Cys Lys Lys Ser 
            20                  25                  30          


Cys Cys Ser Cys Cys Pro Val Gly Cys Ala Lys Cys Ala Gln Gly Cys 
        35                  40                  45              


Ile Cys Lys Gly Ala Ser Glu Lys Cys Ser Cys Cys Ala 
    50                  55                  60      


<210>  9022
<211>  68
<212>  PRT
<213>  Homo Sapiens

<400>  9022

Met Asp Pro Asn Cys Ser Cys Ala Ala Gly Val Ser Cys Thr Cys Ala 
1               5                   10                  15      


Ser Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser Cys Lys Lys Ser 
            20                  25                  30          


Glu Cys Gly Ala Ile Ser Arg Asn Leu Gly Leu Trp Leu Arg Leu Gly 
        35                  40                  45              


Gly Asn Pro Arg Leu Ser Leu Ser Ala Cys Phe Trp Gly Thr Gly Leu 
    50                  55                  60                  


Pro Leu Ser Leu 
65              


<210>  9023
<211>  36
<212>  PRT
<213>  Homo Sapiens

<400>  9023

Met Ala Ala Thr Ser Leu Met Ser Ala Leu Ala Ala Arg Leu Leu Gln 
1               5                   10                  15      


Pro Ala His Ser Cys Ser Leu Arg Leu Arg Pro Phe His Leu Ala Ala 
            20                  25                  30          


Val Arg Ala Tyr 
        35      


<210>  9024
<211>  267
<212>  PRT
<213>  Homo Sapiens

<400>  9024

Met Ala Ala Thr Ser Leu Met Ser Ala Leu Ala Ala Arg Leu Leu Gln 
1               5                   10                  15      


Pro Ala His Ser Cys Ser Leu Arg Leu Arg Pro Phe His Leu Ala Ala 
            20                  25                  30          


Val Arg Asn Glu Ala Val Val Ile Ser Gly Arg Lys Leu Ala Gln Gln 
        35                  40                  45              


Ile Lys Gln Glu Val Arg Gln Glu Val Glu Glu Trp Val Ala Ser Gly 
    50                  55                  60                  


Asn Lys Arg Pro His Leu Ser Val Ile Leu Val Gly Glu Asn Pro Ala 
65                  70                  75                  80  


Ser His Ser Tyr Val Leu Asn Lys Thr Arg Ala Ala Ala Val Val Glu 
                85                  90                  95      


His Ile Asp Glu Arg Arg Ile Cys Asn Ala Val Ser Pro Asp Lys Asp 
            100                 105                 110         


Val Asp Gly Phe His Val Ile Asn Val Gly Arg Met Cys Leu Asp Gln 
        115                 120                 125             


Tyr Ser Met Leu Pro Ala Thr Pro Trp Gly Val Trp Glu Ile Ile Lys 
    130                 135                 140                 


Arg Thr Gly Ile Pro Thr Leu Gly Lys Asn Val Val Val Ala Gly Arg 
145                 150                 155                 160 


Ser Lys Asn Val Gly Met Pro Ile Ala Met Leu Leu His Thr Asp Gly 
                165                 170                 175     


Ala His Glu Arg Pro Gly Gly Asp Ala Thr Val Thr Ile Ser His Arg 
            180                 185                 190         


Tyr Thr Pro Lys Glu Gln Leu Lys Lys His Thr Ile Leu Ala Asp Ile 
        195                 200                 205             


Val Ile Ser Ala Ala Gly Val Arg Gln Lys Ala Gly Tyr Ile Thr Pro 
    210                 215                 220                 


Val Pro Gly Gly Val Gly Pro Met Thr Val Ala Met Leu Met Lys Asn 
225                 230                 235                 240 


Thr Ile Ile Ala Ala Lys Lys Val Leu Arg Leu Glu Glu Arg Glu Val 
                245                 250                 255     


Leu Lys Ser Lys Glu Leu Gly Val Ala Thr Asn 
            260                 265         


<210>  9025
<211>  222
<212>  PRT
<213>  Homo Sapiens

<400>  9025

Met Ala Ala Thr Ser Leu Met Ser Ala Leu Ala Ala Arg Leu Leu Gln 
1               5                   10                  15      


Pro Ala His Ser Cys Ser Leu Arg Leu Arg Pro Phe His Leu Ala Ala 
            20                  25                  30          


Val Arg Asn Glu Ala Val Val Ile Ser Gly Arg Lys Leu Ala Gln Gln 
        35                  40                  45              


Ile Lys Gln Glu Val Arg Gln Glu Val Glu Glu Trp Val Ala Ser Gly 
    50                  55                  60                  


Asn Lys Arg Pro His Leu Ser Val Ile Leu Val Gly Glu Asn Pro Ala 
65                  70                  75                  80  


Ser His Ser Tyr Val Leu Asn Lys Thr Arg Ala Ala Ala Val Val Gly 
                85                  90                  95      


Asp Ala Thr Val Thr Ile Ser His Arg Tyr Thr Pro Lys Glu Gln Leu 
            100                 105                 110         


Lys Lys His Thr Ile Leu Ala Asp Ile Val Ile Ser Ala Ala Gly Ile 
        115                 120                 125             


Pro Asn Leu Ile Thr Ala Asp Met Ile Lys Glu Gly Ala Ala Val Ile 
    130                 135                 140                 


Asp Val Gly Ile Asn Arg Val His Asp Pro Val Thr Ala Lys Pro Lys 
145                 150                 155                 160 


Leu Val Gly Asp Val Asp Phe Glu Gly Val Arg Gln Lys Ala Gly Tyr 
                165                 170                 175     


Ile Thr Pro Val Pro Gly Gly Val Gly Pro Met Thr Val Ala Met Leu 
            180                 185                 190         


Met Lys Asn Thr Ile Ile Ala Ala Lys Lys Val Leu Arg Leu Glu Glu 
        195                 200                 205             


Arg Glu Val Leu Lys Ser Lys Glu Leu Gly Val Ala Thr Asn 
    210                 215                 220         


<210>  9026
<211>  350
<212>  PRT
<213>  Homo Sapiens

<400>  9026

Met Ala Ala Thr Ser Leu Met Ser Ala Leu Ala Ala Arg Leu Leu Gln 
1               5                   10                  15      


Pro Ala His Ser Cys Ser Leu Arg Leu Arg Pro Phe His Leu Ala Ala 
            20                  25                  30          


Val Arg Asn Glu Ala Val Val Ile Ser Gly Arg Lys Leu Ala Gln Gln 
        35                  40                  45              


Ile Lys Gln Glu Val Arg Gln Glu Val Glu Glu Trp Val Ala Ser Gly 
    50                  55                  60                  


Asn Lys Arg Pro His Leu Ser Val Ile Leu Val Gly Glu Asn Pro Ala 
65                  70                  75                  80  


Ser His Ser Tyr Val Leu Asn Lys Thr Arg Ala Ala Ala Val Val Gly 
                85                  90                  95      


Ile Asn Ser Glu Thr Ile Met Lys Pro Ala Ser Ile Ser Glu Glu Glu 
            100                 105                 110         


Leu Leu Asn Leu Ile Asn Lys Leu Asn Asn Asp Asp Asn Val Asp Gly 
        115                 120                 125             


Leu Leu Val Gln Leu Pro Leu Pro Glu His Ile Asp Glu Arg Arg Ile 
    130                 135                 140                 


Cys Asn Ala Val Ser Pro Asp Lys Asp Val Asp Gly Phe His Val Ile 
145                 150                 155                 160 


Asn Val Gly Arg Met Cys Leu Asp Gln Tyr Ser Met Leu Pro Ala Thr 
                165                 170                 175     


Pro Trp Gly Val Trp Glu Ile Ile Lys Arg Thr Gly Ile Pro Thr Leu 
            180                 185                 190         


Gly Lys Asn Val Val Val Ala Gly Arg Ser Lys Asn Val Gly Met Pro 
        195                 200                 205             


Ile Ala Met Leu Leu His Thr Asp Gly Ala His Glu Arg Pro Gly Gly 
    210                 215                 220                 


Asp Ala Thr Val Thr Ile Ser His Arg Tyr Thr Pro Lys Glu Gln Leu 
225                 230                 235                 240 


Lys Lys His Thr Ile Leu Ala Asp Ile Val Ile Ser Ala Ala Gly Ile 
                245                 250                 255     


Pro Asn Leu Ile Thr Ala Asp Met Ile Lys Glu Gly Ala Ala Val Ile 
            260                 265                 270         


Asp Val Gly Ile Asn Arg Val His Asp Pro Val Thr Ala Lys Pro Lys 
        275                 280                 285             


Leu Val Gly Asp Val Asp Phe Glu Gly Val Arg Gln Lys Ala Gly Tyr 
    290                 295                 300                 


Ile Thr Pro Val Pro Gly Gly Val Gly Pro Met Thr Val Ala Met Leu 
305                 310                 315                 320 


Met Lys Asn Thr Ile Ile Ala Ala Lys Lys Val Leu Arg Leu Glu Glu 
                325                 330                 335     


Arg Glu Val Leu Lys Ser Lys Glu Leu Gly Val Ala Thr Asn 
            340                 345                 350 


<210>  9027
<211>  37
<212>  PRT
<213>  Homo Sapiens

<400>  9027

Met Ala Ala Thr Ser Leu Met Ser Ala Leu Ala Ala Arg Leu Leu Gln 
1               5                   10                  15      


Pro Ala His Ser Cys Ser Leu Arg Leu Arg Pro Phe His Leu Ala Ala 
            20                  25                  30          


Val Arg Asn Gln Gln 
        35          


<210>  9028
<211>  292
<212>  PRT
<213>  Homo Sapiens

<400>  9028

Met Ala Gly Ala Arg Ala Ala Ala Ala Ala Ala Ser Ala Gly Ser Ser 
1               5                   10                  15      


Ala Ser Ser Gly Asn Gln Pro Pro Gln Glu Leu Gly Leu Gly Glu Leu 
            20                  25                  30          


Leu Glu Glu Phe Ser Arg Thr Gln Tyr Arg Ala Lys Asp Gly Ser Gly 
        35                  40                  45              


Thr Gly Gly Ser Lys Cys Trp Asp Leu Val Gln Gln Thr Gln Asn Tyr 
    50                  55                  60                  


Leu Lys Leu Leu Leu Ser Leu Val Asn Ser Asp Asp Asp Ser Gly Leu 
65                  70                  75                  80  


Leu Val His Cys Ile Ser Gly Trp Asp Arg Thr Pro Leu Phe Ile Ser 
                85                  90                  95      


Leu Leu Arg Leu Ser Leu Trp Ala Asp Gly Leu Ile His Thr Ser Leu 
            100                 105                 110         


Lys Pro Thr Glu Ile Leu Tyr Leu Thr Val Ala Tyr Asp Trp Phe Leu 
        115                 120                 125             


Phe Gly His Met Leu Val Asp Arg Leu Ser Lys Gly Glu Glu Ile Phe 
    130                 135                 140                 


Phe Phe Cys Phe Asn Phe Leu Lys His Ile Thr Ser Glu Glu Phe Ser 
145                 150                 155                 160 


Ala Leu Lys Thr Gln Arg Arg Lys Ser Leu Pro Ala Arg Asp Gly Gly 
                165                 170                 175     


Phe Thr Leu Glu Asp Ile Cys Met Leu Arg Arg Lys Asp Arg Gly Ser 
            180                 185                 190         


Thr Thr Ser Leu Gly Ser Asp Phe Ser Leu Val Met Glu Ser Ser Pro 
        195                 200                 205             


Gly Ala Thr Gly Ser Phe Thr Tyr Glu Ala Val Glu Leu Val Pro Ala 
    210                 215                 220                 


Gly Ala Pro Thr Gln Ala Ala Trp Leu Ala Ala Leu Ser Asp Arg Glu 
225                 230                 235                 240 


Thr Arg Leu Gln Glu Val Arg Ser Ala Phe Leu Ala Ala Tyr Ser Ser 
                245                 250                 255     


Thr Val Gly Leu Arg Ala Val Ala Pro Ser Pro Ser Gly Ala Ile Gly 
            260                 265                 270         


Gly Leu Leu Glu Gln Phe Ala Arg Gly Val Gly Leu Arg Ser Ile Ser 
        275                 280                 285             


Ser Asn Ala Leu 
    290         


<210>  9029
<211>  71
<212>  PRT
<213>  Homo Sapiens

<400>  9029

Met Ala Gly Ala Arg Ala Ala Ala Ala Ala Ala Ser Ala Gly Ser Ser 
1               5                   10                  15      


Ala Ser Ser Gly Asn Gln Pro Pro Gln Glu Leu Gly Leu Gly Glu Leu 
            20                  25                  30          


Leu Glu Glu Phe Ser Arg Thr Gln Tyr Arg Ala Lys Asp Gly Ser Gly 
        35                  40                  45              


Thr Gly Gly Ser Lys Ser Ser Tyr Arg Gln Thr Trp Arg Ala Ser Cys 
    50                  55                  60                  


Gln Leu Arg Pro Ser Pro Pro 
65                  70      


<210>  9030
<211>  158
<212>  PRT
<213>  Homo Sapiens

<400>  9030

Met Ala Gly Ala Arg Ala Ala Ala Ala Ala Ala Ser Ala Gly Ser Ser 
1               5                   10                  15      


Ala Ser Ser Gly Asn Gln Pro Pro Gln Glu Leu Gly Leu Gly Glu Leu 
            20                  25                  30          


Leu Glu Glu Phe Ser Arg Thr Gln Tyr Arg Ala Lys Asp Gly Ser Gly 
        35                  40                  45              


Thr Gly Gly Ser Lys Val Glu Arg Ile Glu Lys Arg Cys Leu Glu Leu 
    50                  55                  60                  


Phe Gly Arg Asp Tyr Cys Phe Ser Val Ile Pro Asn Thr Asn Gly Asp 
65                  70                  75                  80  


Ile Cys Gly His Tyr Pro Arg His Ile Val Phe Leu Glu Tyr Glu Ser 
                85                  90                  95      


Ser Glu Lys Glu Lys Asp Thr Phe Glu Ser Thr Val Gln Gly Val Gln 
            100                 105                 110         


Met Met Pro Gly Gln Met Trp Arg Thr Ser Arg Arg Arg Thr Val Leu 
        115                 120                 125             


Phe Glu Val Val Thr Arg Ile Phe Leu Ile Arg Ser Glu Ala Met Thr 
    130                 135                 140                 


Ser Ser Cys Phe Asp Thr Cys Gln Ser Asn Thr Ser Val Thr 
145                 150                 155             


<210>  9031
<211>  188
<212>  PRT
<213>  Homo Sapiens

<400>  9031

Met Ala Gly Ala Arg Ala Ala Ala Ala Ala Ala Ser Ala Gly Ser Ser 
1               5                   10                  15      


Ala Ser Ser Gly Asn Gln Pro Pro Gln Glu Leu Gly Leu Gly Glu Leu 
            20                  25                  30          


Leu Glu Glu Phe Ser Arg Thr Gln Tyr Arg Ala Lys Asp Gly Ser Gly 
        35                  40                  45              


Thr Gly Gly Ser Lys Val Glu Arg Ile Glu Lys Arg Cys Leu Glu Leu 
    50                  55                  60                  


Phe Gly Arg Asp Tyr Cys Phe Ser Val Ile Pro Asn Thr Asn Gly Asp 
65                  70                  75                  80  


Ile Cys Gly His Tyr Pro Arg His Ile Val Phe Leu Glu Tyr Glu Ser 
                85                  90                  95      


Ser Glu Lys Glu Lys Asp Thr Phe Glu Ser Thr Val Gln Val Ser Lys 
            100                 105                 110         


Leu Gln Asp Leu Ile His Arg Ser Lys Met Ala Arg Cys Arg Gly Arg 
        115                 120                 125             


Phe Val Cys Pro Val Ile Leu Phe Lys Gly Lys Gly Val Gln Met Met 
    130                 135                 140                 


Pro Gly Gln Met Trp Arg Thr Ser Arg Arg Arg Thr Val Leu Phe Glu 
145                 150                 155                 160 


Val Val Thr Arg Ile Phe Leu Ile Arg Ser Glu Ala Met Thr Ser Ser 
                165                 170                 175     


Cys Phe Asp Thr Cys Gln Ser Asn Thr Ser Val Thr 
            180                 185             


<210>  9032
<211>  650
<212>  PRT
<213>  Homo Sapiens

<400>  9032

Met Ala Gly Ala Arg Ala Ala Ala Ala Ala Ala Ser Ala Gly Ser Ser 
1               5                   10                  15      


Ala Ser Ser Gly Asn Gln Pro Pro Gln Glu Leu Gly Leu Gly Glu Leu 
            20                  25                  30          


Leu Glu Glu Phe Ser Arg Thr Gln Tyr Arg Ala Lys Asp Gly Ser Gly 
        35                  40                  45              


Thr Gly Gly Ser Lys Val Glu Arg Ile Glu Lys Arg Cys Leu Glu Leu 
    50                  55                  60                  


Phe Gly Arg Asp Tyr Cys Phe Ser Val Ile Pro Asn Thr Asn Gly Asp 
65                  70                  75                  80  


Ile Cys Gly His Tyr Pro Arg His Ile Val Phe Leu Glu Tyr Glu Ser 
                85                  90                  95      


Ser Glu Lys Glu Lys Asp Thr Phe Glu Ser Thr Val Gln Val Ser Lys 
            100                 105                 110         


Leu Gln Asp Leu Ile His Arg Ser Lys Met Ala Arg Cys Arg Gly Arg 
        115                 120                 125             


Phe Val Cys Pro Val Ile Leu Phe Lys Gly Lys His Ile Cys Arg Ser 
    130                 135                 140                 


Ala Thr Leu Ala Gly Trp Gly Glu Leu Tyr Gly Arg Ser Gly Tyr Asn 
145                 150                 155                 160 


Tyr Phe Phe Ser Gly Gly Ala Asp Asp Ala Trp Ala Asp Val Glu Asp 
                165                 170                 175     


Val Thr Glu Glu Asp Cys Ala Leu Arg Ser Gly Asp Thr His Leu Phe 
            180                 185                 190         


Asp Lys Val Arg Gly Tyr Asp Ile Lys Leu Leu Arg Tyr Leu Ser Val 
        195                 200                 205             


Lys Tyr Ile Cys Asp Leu Met Val Glu Asn Lys Lys Val Lys Phe Gly 
    210                 215                 220                 


Met Asn Val Thr Ser Ser Glu Lys Val Asp Lys Ala Gln Arg Tyr Ala 
225                 230                 235                 240 


Asp Phe Thr Leu Leu Ser Ile Pro Tyr Pro Gly Cys Glu Phe Phe Lys 
                245                 250                 255     


Glu Tyr Lys Asp Arg Asp Tyr Met Ala Glu Gly Leu Ile Phe Asn Trp 
            260                 265                 270         


Lys Gln Asp Tyr Val Asp Ala Pro Leu Ser Ile Pro Asp Phe Leu Thr 
        275                 280                 285             


His Ser Leu Asn Ile Asp Trp Ser Gln Tyr Gln Cys Trp Asp Leu Val 
    290                 295                 300                 


Gln Gln Thr Gln Asn Tyr Leu Lys Leu Leu Leu Ser Leu Val Asn Ser 
305                 310                 315                 320 


Asp Asp Asp Ser Gly Leu Leu Val His Cys Ile Ser Gly Trp Asp Arg 
                325                 330                 335     


Thr Pro Leu Phe Ile Ser Leu Leu Arg Leu Ser Leu Trp Ala Asp Gly 
            340                 345                 350         


Leu Ile His Thr Ser Leu Lys Pro Thr Glu Ile Leu Tyr Leu Thr Val 
        355                 360                 365             


Ala Tyr Asp Trp Phe Leu Phe Gly His Met Leu Val Asp Arg Leu Ser 
    370                 375                 380                 


Lys Gly Glu Glu Ile Phe Phe Phe Cys Phe Asn Phe Leu Lys His Ile 
385                 390                 395                 400 


Thr Ser Glu Glu Phe Ser Ala Leu Lys Thr Gln Arg Arg Lys Ser Leu 
                405                 410                 415     


Pro Ala Arg Asp Gly Gly Phe Thr Leu Glu Asp Ile Cys Met Leu Arg 
            420                 425                 430         


Arg Lys Asp Arg Gly Ser Thr Thr Ser Leu Gly Ser Asp Phe Ser Leu 
        435                 440                 445             


Val Met Glu Ser Ser Pro Gly Ala Thr Gly Ser Phe Thr Tyr Glu Ala 
    450                 455                 460                 


Val Glu Leu Val Pro Ala Gly Ala Pro Thr Gln Ala Ala Trp Arg Lys 
465                 470                 475                 480 


Ser His Ser Ser Ser Pro Gln Ser Val Leu Trp Asn Arg Pro Gln Pro 
                485                 490                 495     


Ser Glu Asp Arg Leu Pro Ser Gln Gln Gly Leu Ala Glu Ala Arg Ser 
            500                 505                 510         


Ser Ser Ser Ser Ser Ser Asn His Ser Asp Asn Phe Phe Arg Met Gly 
        515                 520                 525             


Ser Ser Pro Leu Glu Val Pro Lys Pro Arg Ser Val Asp His Pro Leu 
    530                 535                 540                 


Pro Gly Ser Ser Leu Ser Thr Asp Tyr Gly Ser Trp Gln Met Val Thr 
545                 550                 555                 560 


Gly Cys Gly Ser Ile Gln Glu Arg Ala Val Leu His Thr Asp Ser Ser 
                565                 570                 575     


Leu Pro Phe Ser Phe Pro Asp Glu Leu Pro Asn Ser Cys Leu Leu Ala 
            580                 585                 590         


Ala Leu Ser Asp Arg Glu Thr Arg Leu Gln Glu Val Arg Ser Ala Phe 
        595                 600                 605             


Leu Ala Ala Tyr Ser Ser Thr Val Gly Leu Arg Ala Val Ala Pro Ser 
    610                 615                 620                 


Pro Ser Gly Ala Ile Gly Gly Leu Leu Glu Gln Phe Ala Arg Gly Val 
625                 630                 635                 640 


Gly Leu Arg Ser Ile Ser Ser Asn Ala Leu 
                645                 650 


<210>  9033
<211>  598
<212>  PRT
<213>  Homo Sapiens

<400>  9033

Met Ala Gly Ala Arg Ala Ala Ala Ala Ala Ala Ser Ala Gly Ser Ser 
1               5                   10                  15      


Ala Ser Ser Gly Asn Gln Pro Pro Gln Glu Leu Gly Leu Gly Glu Leu 
            20                  25                  30          


Leu Glu Glu Phe Ser Arg Thr Gln Tyr Arg Ala Lys Asp Gly Ser Gly 
        35                  40                  45              


Thr Gly Gly Ser Lys Val Glu Arg Ile Glu Lys Arg Cys Leu Glu Leu 
    50                  55                  60                  


Phe Gly Arg Asp Tyr Cys Phe Ser Val Ile Pro Asn Thr Asn Gly Asp 
65                  70                  75                  80  


Ile Cys Gly His Tyr Pro Arg His Ile Val Phe Leu Glu Tyr Glu Ser 
                85                  90                  95      


Ser Glu Lys Glu Lys Asp Thr Phe Glu Ser Thr Val Gln Val Ser Lys 
            100                 105                 110         


Leu Gln Asp Leu Ile His Arg Ser Lys Met Ala Arg Cys Arg Gly Arg 
        115                 120                 125             


Phe Val Cys Pro Val Ile Leu Phe Lys Gly Lys His Ile Cys Arg Ser 
    130                 135                 140                 


Ala Thr Leu Ala Gly Trp Gly Glu Leu Tyr Gly Arg Ser Gly Tyr Asn 
145                 150                 155                 160 


Tyr Phe Phe Ser Gly Gly Ala Asp Asp Ala Trp Ala Asp Val Glu Asp 
                165                 170                 175     


Val Thr Glu Glu Asp Cys Ala Leu Arg Ser Gly Asp Thr His Leu Phe 
            180                 185                 190         


Asp Lys Val Arg Gly Tyr Asp Ile Lys Leu Leu Arg Tyr Leu Ser Val 
        195                 200                 205             


Lys Tyr Ile Cys Asp Leu Met Val Glu Asn Lys Lys Val Lys Phe Gly 
    210                 215                 220                 


Met Asn Val Thr Ser Ser Glu Lys Val Asp Lys Ala Gln Arg Tyr Ala 
225                 230                 235                 240 


Asp Phe Thr Leu Leu Ser Ile Pro Tyr Pro Gly Cys Glu Phe Phe Lys 
                245                 250                 255     


Glu Tyr Lys Asp Arg Asp Tyr Met Ala Glu Gly Leu Ile Phe Asn Trp 
            260                 265                 270         


Lys Gln Asp Tyr Val Asp Ala Pro Leu Ser Ile Pro Asp Phe Leu Thr 
        275                 280                 285             


His Ser Leu Asn Ile Asp Trp Ser Gln Tyr Gln Cys Trp Asp Leu Val 
    290                 295                 300                 


Gln Gln Thr Gln Asn Tyr Leu Lys Leu Leu Leu Ser Leu Val Asn Ser 
305                 310                 315                 320 


Asp Asp Asp Ser Gly Leu Leu Val His Cys Ile Ser Gly Trp Asp Arg 
                325                 330                 335     


Thr Pro Leu Phe Ile Ser Leu Leu Arg Leu Ser Leu Trp Ala Asp Gly 
            340                 345                 350         


Leu Ile His Thr Ser Leu Lys Pro Thr Glu Ile Leu Tyr Leu Thr Val 
        355                 360                 365             


Ala Tyr Asp Trp Phe Leu Phe Gly His Met Leu Val Asp Arg Leu Ser 
    370                 375                 380                 


Lys Gly Glu Glu Ile Phe Phe Phe Cys Phe Asn Phe Leu Lys His Ile 
385                 390                 395                 400 


Thr Ser Glu Glu Phe Ser Ala Leu Lys Thr Gln Arg Arg Lys Ser Leu 
                405                 410                 415     


Pro Ala Arg Asp Gly Gly Phe Thr Leu Glu Asp Ile Cys Met Leu Arg 
            420                 425                 430         


Arg Lys Asp Arg Gly Ser Thr Thr Ser Leu Gly Ser Asp Phe Ser Leu 
        435                 440                 445             


Val Met Glu Ser Ser Pro Gly Ala Thr Gly Ser Phe Thr Tyr Glu Ala 
    450                 455                 460                 


Val Glu Leu Val Pro Ala Gly Ala Pro Thr Gln Ala Ala Trp Arg Lys 
465                 470                 475                 480 


Ser His Ser Ser Ser Pro Gln Ser Val Leu Trp Asn Arg Pro Gln Pro 
                485                 490                 495     


Ser Glu Asp Arg Leu Pro Ser Gln Gln Gly Leu Ala Glu Ala Arg Ser 
            500                 505                 510         


Ser Ser Ser Ser Ser Ser Asn His Ser Asp Asn Phe Phe Arg Met Gly 
        515                 520                 525             


Ser Ser Pro Leu Glu Val Pro Lys Pro Arg Leu Ala Ala Leu Ser Asp 
    530                 535                 540                 


Arg Glu Thr Arg Leu Gln Glu Val Arg Ser Ala Phe Leu Ala Ala Tyr 
545                 550                 555                 560 


Ser Ser Thr Val Gly Leu Arg Ala Val Ala Pro Ser Pro Ser Gly Ala 
                565                 570                 575     


Ile Gly Gly Leu Leu Glu Gln Phe Ala Arg Gly Val Gly Leu Arg Ser 
            580                 585                 590         


Ile Ser Ser Asn Ala Leu 
        595             


<210>  9034
<211>  538
<212>  PRT
<213>  Homo Sapiens

<400>  9034

Met Ala Gly Ala Arg Ala Ala Ala Ala Ala Ala Ser Ala Gly Ser Ser 
1               5                   10                  15      


Ala Ser Ser Gly Asn Gln Pro Pro Gln Glu Leu Gly Leu Gly Glu Leu 
            20                  25                  30          


Leu Glu Glu Phe Ser Arg Thr Gln Tyr Arg Ala Lys Asp Gly Ser Gly 
        35                  40                  45              


Thr Gly Gly Ser Lys Val Glu Arg Ile Glu Lys Arg Cys Leu Glu Leu 
    50                  55                  60                  


Phe Gly Arg Asp Tyr Cys Phe Ser Val Ile Pro Asn Thr Asn Gly Asp 
65                  70                  75                  80  


Ile Cys Gly His Tyr Pro Arg His Ile Val Phe Leu Glu Tyr Glu Ser 
                85                  90                  95      


Ser Glu Lys Glu Lys Asp Thr Phe Glu Ser Thr Val Gln Val Ser Lys 
            100                 105                 110         


Leu Gln Asp Leu Ile His Arg Ser Lys Met Ala Arg Cys Arg Gly Arg 
        115                 120                 125             


Phe Val Cys Pro Val Ile Leu Phe Lys Gly Lys His Ile Cys Arg Ser 
    130                 135                 140                 


Ala Thr Leu Ala Gly Trp Gly Glu Leu Tyr Gly Arg Ser Gly Tyr Asn 
145                 150                 155                 160 


Tyr Phe Phe Ser Gly Gly Ala Asp Asp Ala Trp Ala Asp Val Glu Asp 
                165                 170                 175     


Val Thr Glu Glu Asp Cys Ala Leu Arg Ser Gly Asp Thr His Leu Phe 
            180                 185                 190         


Asp Lys Val Arg Gly Tyr Asp Ile Lys Leu Leu Arg Tyr Leu Ser Val 
        195                 200                 205             


Lys Tyr Ile Cys Asp Leu Met Val Glu Asn Lys Lys Val Lys Phe Gly 
    210                 215                 220                 


Met Asn Val Thr Ser Ser Glu Lys Val Asp Lys Ala Gln Arg Tyr Ala 
225                 230                 235                 240 


Asp Phe Thr Leu Leu Ser Ile Pro Tyr Pro Gly Cys Glu Phe Phe Lys 
                245                 250                 255     


Glu Tyr Lys Asp Arg Asp Tyr Met Ala Glu Gly Leu Ile Phe Asn Trp 
            260                 265                 270         


Lys Gln Asp Tyr Val Asp Ala Pro Leu Ser Ile Pro Asp Phe Leu Thr 
        275                 280                 285             


His Ser Leu Asn Ile Asp Trp Ser Gln Tyr Gln Cys Trp Asp Leu Val 
    290                 295                 300                 


Gln Gln Thr Gln Asn Tyr Leu Lys Leu Leu Leu Ser Leu Val Asn Ser 
305                 310                 315                 320 


Asp Asp Asp Ser Gly Leu Leu Val His Cys Ile Ser Gly Trp Asp Arg 
                325                 330                 335     


Thr Pro Leu Phe Ile Ser Leu Leu Arg Leu Ser Leu Trp Ala Asp Gly 
            340                 345                 350         


Leu Ile His Thr Ser Leu Lys Pro Thr Glu Ile Leu Tyr Leu Thr Val 
        355                 360                 365             


Ala Tyr Asp Trp Phe Leu Phe Gly His Met Leu Val Asp Arg Leu Ser 
    370                 375                 380                 


Lys Gly Glu Glu Ile Phe Phe Phe Cys Phe Asn Phe Leu Lys His Ile 
385                 390                 395                 400 


Thr Ser Glu Glu Phe Ser Ala Leu Lys Thr Gln Arg Arg Lys Ser Leu 
                405                 410                 415     


Pro Ala Arg Asp Gly Gly Phe Thr Leu Glu Asp Ile Cys Met Leu Arg 
            420                 425                 430         


Arg Lys Asp Arg Gly Ser Thr Thr Ser Leu Gly Ser Asp Phe Ser Leu 
        435                 440                 445             


Val Met Glu Ser Ser Pro Gly Ala Thr Gly Ser Phe Thr Tyr Glu Ala 
    450                 455                 460                 


Val Glu Leu Val Pro Ala Gly Ala Pro Thr Gln Ala Ala Trp Leu Ala 
465                 470                 475                 480 


Ala Leu Ser Asp Arg Glu Thr Arg Leu Gln Glu Val Arg Ser Ala Phe 
                485                 490                 495     


Leu Ala Ala Tyr Ser Ser Thr Val Gly Leu Arg Ala Val Ala Pro Ser 
            500                 505                 510         


Pro Ser Gly Ala Ile Gly Gly Leu Leu Glu Gln Phe Ala Arg Gly Val 
        515                 520                 525             


Gly Leu Arg Ser Ile Ser Ser Asn Ala Leu 
    530                 535             


<210>  9035
<211>  187
<212>  PRT
<213>  Homo Sapiens

<400>  9035

Met Ala Gly Ala Arg Ala Ala Ala Ala Ala Ala Ser Ala Gly Ser Ser 
1               5                   10                  15      


Ala Ser Ser Gly Asn Gln Pro Pro Gln Glu Leu Gly Leu Gly Glu Leu 
            20                  25                  30          


Leu Glu Glu Phe Ser Arg Thr Gln Tyr Arg Ala Lys Asp Gly Ser Gly 
        35                  40                  45              


Thr Gly Gly Ser Lys Val Glu Arg Ile Glu Lys Arg Cys Leu Glu Leu 
    50                  55                  60                  


Phe Gly Arg Asp Tyr Cys Phe Ser Val Ile Pro Asn Thr Asn Gly Asp 
65                  70                  75                  80  


Ile Cys Gly His Tyr Pro Arg His Ile Val Phe Leu Glu Tyr Glu Ser 
                85                  90                  95      


Ser Glu Lys Glu Lys Asp Thr Ser Gly Asp Thr His Leu Phe Asp Lys 
            100                 105                 110         


Val Arg Gly Tyr Asp Ile Lys Leu Leu Arg Tyr Leu Ser Val Lys Tyr 
        115                 120                 125             


Ile Cys Asp Leu Met Val Glu Asn Lys Lys Val Lys Phe Gly Met Asn 
    130                 135                 140                 


Val Thr Ser Ser Glu Lys Val Asp Lys Ala Gln Arg Tyr Ala Asp Phe 
145                 150                 155                 160 


Thr Leu Leu Ser Ile Pro Tyr Pro Val Leu Gly Ser Gly Ala Thr Asn 
                165                 170                 175     


Thr Lys Leu Pro Glu Ala Ala Ala Phe Leu Ser 
            180                 185         


<210>  9036
<211>  154
<212>  PRT
<213>  Homo Sapiens

<400>  9036

Met Ala Leu Leu Ile Leu Leu Leu Val Pro Leu Leu Leu Pro Asp Ser 
1               5                   10                  15      


Gly Ser Glu Ala Tyr Ser Gly Cys Glu Phe Phe Lys Glu Tyr Lys Asp 
            20                  25                  30          


Arg Asp Tyr Met Ala Glu Gly Leu Ile Phe Asn Trp Lys Gln Asp Tyr 
        35                  40                  45              


Val Asp Ala Pro Leu Ser Ile Pro Asp Phe Leu Thr His Ser Leu Asn 
    50                  55                  60                  


Ile Asp Trp Ser Gln Tyr Gln Cys Trp Asp Leu Val Gln Gln Thr Gln 
65                  70                  75                  80  


Asn Tyr Leu Lys Leu Leu Leu Ser Leu Val Asn Ser Asp Asp Asp Ser 
                85                  90                  95      


Gly Leu Leu Val His Cys Ile Ser Gly Trp Asp Arg Thr Pro Leu Phe 
            100                 105                 110         


Ile Ser Leu Leu Arg Leu Ser Leu Trp Ala Asp Gly Leu Ile His Thr 
        115                 120                 125             


Ser Leu Lys Pro Thr Glu Ile Leu Tyr Leu Thr Val Ala Tyr Asp Trp 
    130                 135                 140                 


Phe Leu Phe Gly His Met Leu Val Asp Arg 
145                 150                 


<210>  9037
<211>  60
<212>  PRT
<213>  Homo Sapiens

<400>  9037

Met Asp Ala Gln Ala Thr Thr Ile Phe Ser Gln Gly Val Gln Met Met 
1               5                   10                  15      


Pro Gly Gln Met Trp Arg Thr Ser Arg Arg Arg Thr Val Leu Phe Glu 
            20                  25                  30          


Val Val Thr Arg Ile Phe Leu Ile Arg Ser Glu Ala Met Thr Ser Ser 
        35                  40                  45              


Cys Phe Asp Thr Cys Gln Ser Asn Thr Ser Val Thr 
    50                  55                  60  


<210>  9038
<211>  36
<212>  PRT
<213>  Homo Sapiens

<400>  9038

Met Ser His Cys Ala Trp Pro Glu Thr Glu Leu Glu Leu Asp Val Gly 
1               5                   10                  15      


Glu Pro Val Lys Glu Pro Leu Ala Asp Leu Thr Arg Lys Gly Leu Arg 
            20                  25                  30          


Val Pro Tyr Arg 
        35      


<210>  9039
<211>  24
<212>  PRT
<213>  Homo Sapiens

<400>  9039

Met Ala Thr Arg Gly Phe Ser Cys Leu Leu Leu Val Ile Ser Glu Ile 
1               5                   10                  15      


Asp Leu Ser Val Lys Arg Trp Val 
            20                  


<210>  9040
<211>  725
<212>  PRT
<213>  Homo Sapiens

<400>  9040

Met Gly Ala Ala Ser Val Arg Ala Gly Ala Arg Leu Val Glu Val Ala 
1               5                   10                  15      


Leu Cys Ser Phe Thr Val Thr Cys Leu Glu Val Met Arg Arg Phe Leu 
            20                  25                  30          


Leu Leu Tyr Ala Thr Gln Gln Gly Gln Ala Lys Ala Ile Ala Glu Glu 
        35                  40                  45              


Ile Cys Glu Gln Ala Val Val His Gly Phe Ser Ala Asp Leu His Cys 
    50                  55                  60                  


Ile Ser Glu Ser Asp Lys Tyr Asp Leu Lys Thr Glu Thr Ala Pro Leu 
65                  70                  75                  80  


Val Val Val Val Ser Thr Thr Gly Thr Gly Asp Pro Pro Asp Thr Ala 
                85                  90                  95      


Arg Lys Phe Val Lys Glu Ile Gln Asn Gln Thr Leu Pro Val Asp Phe 
            100                 105                 110         


Phe Ala His Leu Arg Tyr Gly Leu Leu Gly Leu Gly Asp Ser Glu Tyr 
        115                 120                 125             


Thr Tyr Phe Cys Asn Gly Gly Lys Ile Ile Asp Lys Arg Leu Gln Glu 
    130                 135                 140                 


Leu Gly Ala Arg His Phe Tyr Asp Thr Gly His Ala Asp Asp Cys Val 
145                 150                 155                 160 


Gly Leu Glu Leu Val Val Glu Pro Trp Ile Ala Gly Leu Trp Pro Ala 
                165                 170                 175     


Leu Arg Lys His Phe Arg Ser Ser Arg Gly Gln Glu Glu Ile Ser Gly 
            180                 185                 190         


Ala Leu Pro Val Ala Ser Pro Ala Ser Ser Arg Thr Asp Leu Val Lys 
        195                 200                 205             


Ser Glu Leu Leu His Ile Glu Ser Gln Val Glu Leu Leu Arg Phe Asp 
    210                 215                 220                 


Asp Ser Gly Arg Lys Asp Ser Glu Val Leu Lys Gln Asn Ala Val Asn 
225                 230                 235                 240 


Ser Asn Gln Ser Asn Val Val Ile Glu Asp Phe Glu Ser Ser Leu Thr 
                245                 250                 255     


Arg Ser Val Pro Pro Leu Ser Gln Ala Ser Leu Asn Ile Pro Gly Leu 
            260                 265                 270         


Pro Pro Glu Tyr Leu Gln Val His Leu Gln Glu Ser Leu Gly Gln Glu 
        275                 280                 285             


Glu Ser Gln Val Ser Val Thr Ser Ala Asp Pro Val Phe Gln Val Pro 
    290                 295                 300                 


Ile Ser Lys Ala Val Gln Leu Thr Thr Asn Asp Ala Ile Lys Thr Thr 
305                 310                 315                 320 


Leu Leu Val Glu Leu Asp Ile Ser Asn Thr Asp Phe Ser Tyr Gln Pro 
                325                 330                 335     


Gly Asp Ala Phe Ser Val Ile Cys Pro Asn Ser Asp Ser Glu Val Gln 
            340                 345                 350         


Ser Leu Leu Gln Arg Leu Gln Leu Glu Asp Lys Arg Glu His Cys Val 
        355                 360                 365             


Leu Leu Lys Ile Lys Ala Asp Thr Lys Lys Lys Gly Ala Thr Leu Pro 
    370                 375                 380                 


Gln His Ile Pro Ala Gly Cys Ser Leu Gln Phe Ile Phe Thr Trp Cys 
385                 390                 395                 400 


Leu Glu Ile Arg Ala Ile Pro Lys Lys Ala Phe Leu Arg Ala Leu Val 
                405                 410                 415     


Asp Tyr Thr Ser Asp Ser Ala Glu Lys Arg Arg Leu Gln Glu Leu Cys 
            420                 425                 430         


Ser Lys Gln Gly Ala Ala Asp Tyr Ser Arg Phe Val Arg Asp Ala Cys 
        435                 440                 445             


Ala Cys Leu Leu Asp Leu Leu Leu Ala Phe Pro Ser Cys Gln Pro Pro 
    450                 455                 460                 


Leu Ser Leu Leu Leu Glu His Leu Pro Lys Leu Gln Pro Arg Pro Tyr 
465                 470                 475                 480 


Ser Cys Ala Ser Ser Ser Leu Phe His Pro Gly Lys Leu His Phe Val 
                485                 490                 495     


Phe Asn Ile Val Glu Phe Leu Ser Thr Ala Thr Thr Glu Val Leu Arg 
            500                 505                 510         


Lys Gly Val Cys Thr Gly Trp Leu Ala Leu Leu Val Ala Ser Val Leu 
        515                 520                 525             


Gln Pro Asn Ile His Ala Ser His Glu Asp Ser Gly Lys Ala Leu Ala 
    530                 535                 540                 


Pro Lys Ile Ser Ile Ser Pro Arg Thr Thr Asn Ser Phe His Leu Pro 
545                 550                 555                 560 


Asp Asp Pro Ser Ile Pro Ile Ile Met Val Gly Pro Gly Thr Gly Ile 
                565                 570                 575     


Ala Pro Phe Ile Gly Phe Leu Gln His Arg Glu Lys Leu Gln Glu Gln 
            580                 585                 590         


His Pro Asp Gly Asn Phe Gly Ala Met Trp Leu Phe Phe Gly Cys Arg 
        595                 600                 605             


His Lys Asp Arg Asp Tyr Leu Phe Arg Lys Glu Leu Arg His Phe Leu 
    610                 615                 620                 


Lys His Gly Ile Leu Thr His Leu Lys Val Ser Phe Ser Arg Asp Ala 
625                 630                 635                 640 


Pro Val Gly Glu Glu Glu Ala Pro Ala Lys Tyr Val Gln Asp Asn Ile 
                645                 650                 655     


Gln Leu His Gly Gln Gln Val Ala Arg Ile Leu Leu Gln Glu Asn Gly 
            660                 665                 670         


His Ile Tyr Val Cys Gly Asp Ala Lys Asn Met Ala Lys Asp Val His 
        675                 680                 685             


Asp Ala Leu Val Gln Ile Ile Ser Lys Glu Val Gly Val Glu Lys Leu 
    690                 695                 700                 


Glu Ala Met Lys Thr Leu Ala Thr Leu Lys Glu Glu Lys Arg Tyr Leu 
705                 710                 715                 720 


Gln Asp Ile Trp Ser 
                725 


<210>  9041
<211>  41
<212>  PRT
<213>  Homo Sapiens

<400>  9041

Met Arg Arg Phe Leu Leu Leu Tyr Ala Thr Gln Gln Gly Gln Ala Lys 
1               5                   10                  15      


Ala Ile Ala Glu Glu Ile Cys Glu Gln Ala Val Val His Gly Phe Ser 
            20                  25                  30          


Ala Asp Leu His Cys Ile Ser Glu Ser 
        35                  40      


<210>  9042
<211>  46
<212>  PRT
<213>  Homo Sapiens

<400>  9042

Met Arg Arg Phe Leu Leu Leu Tyr Ala Thr Gln Gln Gly Gln Ala Lys 
1               5                   10                  15      


Ala Ile Ala Glu Glu Ile Cys Glu Gln Ala Val Val His Gly Phe Ser 
            20                  25                  30          


Ala Asp Leu His Cys Ile Ser Glu Ser Asp Lys Cys Glu Lys 
        35                  40                  45      


<210>  9043
<211>  58
<212>  PRT
<213>  Homo Sapiens

<400>  9043

Met Arg Arg Phe Leu Leu Leu Tyr Ala Thr Gln Gln Gly Gln Ala Lys 
1               5                   10                  15      


Ala Ile Ala Glu Glu Ile Cys Glu Gln Ala Val Val His Gly Phe Ser 
            20                  25                  30          


Ala Asp Leu His Cys Ile Ser Glu Ser Asp Lys Val Ser Val Ile Gln 
        35                  40                  45              


Asn Thr Pro Thr Phe Ala Met Gly Gly Arg 
    50                  55              


<210>  9044
<211>  58
<212>  PRT
<213>  Homo Sapiens

<400>  9044

Met Arg Arg Phe Leu Leu Leu Tyr Ala Thr Gln Gln Gly Gln Ala Lys 
1               5                   10                  15      


Ala Ile Ala Glu Glu Ile Cys Glu Gln Ala Val Val His Gly Phe Ser 
            20                  25                  30          


Ala Asp Leu His Cys Ile Ser Glu Ser Asp Lys Val Ser Val Ile Gln 
        35                  40                  45              


Asn Thr Pro Thr Phe Ala Met Gly Gly Arg 
    50                  55              


<210>  9045
<211>  92
<212>  PRT
<213>  Homo Sapiens

<400>  9045

Met Arg Arg Phe Leu Leu Leu Tyr Ala Thr Gln Gln Gly Gln Ala Lys 
1               5                   10                  15      


Ala Ile Ala Glu Glu Ile Cys Glu Gln Ala Val Val His Gly Phe Ser 
            20                  25                  30          


Ala Asp Leu His Cys Ile Ser Glu Ser Asp Lys Tyr Asp Leu Lys Thr 
        35                  40                  45              


Glu Thr Ala Pro Leu Val Val Val Val Ser Thr Thr Gly Thr Gly Asp 
    50                  55                  60                  


Pro Pro Asp Thr Ala Arg Lys Phe Val Lys Glu Ile Gln Asn Gln Thr 
65                  70                  75                  80  


Leu Pro Val Asp Phe Phe Ala His Leu Arg Ser Arg 
                85                  90          


<210>  9046
<211>  112
<212>  PRT
<213>  Homo Sapiens

<400>  9046

Met Arg Arg Phe Leu Leu Leu Tyr Ala Thr Gln Gln Gly Gln Ala Lys 
1               5                   10                  15      


Ala Ile Ala Glu Glu Ile Cys Glu Gln Ala Val Val His Gly Phe Ser 
            20                  25                  30          


Ala Asp Leu His Cys Ile Ser Glu Ser Asp Lys Tyr Asp Leu Lys Thr 
        35                  40                  45              


Glu Thr Ala Pro Leu Val Val Val Val Ser Thr Thr Gly Thr Gly Asp 
    50                  55                  60                  


Pro Pro Asp Thr Ala Arg Lys Phe Val Lys Glu Ile Gln Asn Gln Thr 
65                  70                  75                  80  


Leu Pro Val Asp Phe Phe Ala His Leu Arg Tyr Gly Leu Leu Gly Leu 
                85                  90                  95      


Gly Asp Ser Glu Tyr Thr Tyr Phe Cys Asn Gly Gly Lys Ile Ile Asp 
            100                 105                 110         


<210>  9047
<211>  156
<212>  PRT
<213>  Homo Sapiens

<400>  9047

Met Arg Arg Phe Leu Leu Leu Tyr Ala Thr Gln Gln Gly Gln Ala Lys 
1               5                   10                  15      


Ala Ile Ala Glu Glu Ile Cys Glu Gln Ala Val Val His Gly Phe Ser 
            20                  25                  30          


Ala Asp Leu His Cys Ile Ser Glu Ser Asp Lys Tyr Asp Leu Lys Thr 
        35                  40                  45              


Glu Thr Ala Pro Leu Val Val Val Val Ser Thr Thr Gly Thr Gly Asp 
    50                  55                  60                  


Pro Pro Asp Thr Ala Arg Lys Phe Val Lys Glu Ile Gln Asn Gln Thr 
65                  70                  75                  80  


Leu Pro Val Asp Phe Phe Ala His Leu Arg Tyr Gly Leu Leu Gly Leu 
                85                  90                  95      


Gly Asp Ser Glu Tyr Thr Tyr Phe Cys Asn Gly Gly Lys Ile Ile Asp 
            100                 105                 110         


Lys Arg Leu Gln Glu Leu Gly Ala Arg His Phe Tyr Asp Thr Gly His 
        115                 120                 125             


Ala Asp Asp Cys Val Gly Leu Glu Leu Val Val Glu Pro Trp Ile Ala 
    130                 135                 140                 


Gly Leu Trp Pro Ala Leu Arg Lys His Phe Arg Ser 
145                 150                 155     


<210>  9048
<211>  698
<212>  PRT
<213>  Homo Sapiens

<400>  9048

Met Arg Arg Phe Leu Leu Leu Tyr Ala Thr Gln Gln Gly Gln Ala Lys 
1               5                   10                  15      


Ala Ile Ala Glu Glu Ile Cys Glu Gln Ala Val Val His Gly Phe Ser 
            20                  25                  30          


Ala Asp Leu His Cys Ile Ser Glu Ser Asp Lys Tyr Asp Leu Lys Thr 
        35                  40                  45              


Glu Thr Ala Pro Leu Val Val Val Val Ser Thr Thr Gly Thr Gly Asp 
    50                  55                  60                  


Pro Pro Asp Thr Ala Arg Lys Phe Val Lys Glu Ile Gln Asn Gln Thr 
65                  70                  75                  80  


Leu Pro Val Asp Phe Phe Ala His Leu Arg Tyr Gly Leu Leu Gly Leu 
                85                  90                  95      


Gly Asp Ser Glu Tyr Thr Tyr Phe Cys Asn Gly Gly Lys Ile Ile Asp 
            100                 105                 110         


Lys Arg Leu Gln Glu Leu Gly Ala Arg His Phe Tyr Asp Thr Gly His 
        115                 120                 125             


Ala Asp Asp Cys Val Gly Leu Glu Leu Val Val Glu Pro Trp Ile Ala 
    130                 135                 140                 


Gly Leu Trp Pro Ala Leu Arg Lys His Phe Arg Ser Ser Arg Gly Gln 
145                 150                 155                 160 


Glu Glu Ile Ser Gly Ala Leu Pro Val Ala Ser Pro Ala Ser Ser Arg 
                165                 170                 175     


Thr Asp Leu Val Lys Ser Glu Leu Leu His Ile Glu Ser Gln Val Glu 
            180                 185                 190         


Leu Leu Arg Phe Asp Asp Ser Gly Arg Lys Asp Ser Glu Val Leu Lys 
        195                 200                 205             


Gln Asn Ala Val Asn Ser Asn Gln Ser Asn Val Val Ile Glu Asp Phe 
    210                 215                 220                 


Glu Ser Ser Leu Thr Arg Ser Val Pro Pro Leu Ser Gln Ala Ser Leu 
225                 230                 235                 240 


Asn Ile Pro Gly Leu Pro Pro Glu Tyr Leu Gln Val His Leu Gln Glu 
                245                 250                 255     


Ser Leu Gly Gln Glu Glu Ser Gln Val Ser Val Thr Ser Ala Asp Pro 
            260                 265                 270         


Val Phe Gln Val Pro Ile Ser Lys Ala Val Gln Leu Thr Thr Asn Asp 
        275                 280                 285             


Ala Ile Lys Thr Thr Leu Leu Val Glu Leu Asp Ile Ser Asn Thr Asp 
    290                 295                 300                 


Phe Ser Tyr Gln Pro Gly Asp Ala Phe Ser Val Ile Cys Pro Asn Ser 
305                 310                 315                 320 


Asp Ser Glu Val Gln Ser Leu Leu Gln Arg Leu Gln Leu Glu Asp Lys 
                325                 330                 335     


Arg Glu His Cys Val Leu Leu Lys Ile Lys Ala Asp Thr Lys Lys Lys 
            340                 345                 350         


Gly Ala Thr Leu Pro Gln His Ile Pro Ala Gly Cys Ser Leu Gln Phe 
        355                 360                 365             


Ile Phe Thr Trp Cys Leu Glu Ile Arg Ala Ile Pro Lys Lys Ala Phe 
    370                 375                 380                 


Leu Arg Ala Leu Val Asp Tyr Thr Ser Asp Ser Ala Glu Lys Arg Arg 
385                 390                 395                 400 


Leu Gln Glu Leu Cys Ser Lys Gln Gly Ala Ala Asp Tyr Ser Arg Phe 
                405                 410                 415     


Val Arg Asp Ala Cys Ala Cys Leu Leu Asp Leu Leu Leu Ala Phe Pro 
            420                 425                 430         


Ser Cys Gln Pro Pro Leu Ser Leu Leu Leu Glu His Leu Pro Lys Leu 
        435                 440                 445             


Gln Pro Arg Pro Tyr Ser Cys Ala Ser Ser Ser Leu Phe His Pro Gly 
    450                 455                 460                 


Lys Leu His Phe Val Phe Asn Ile Val Glu Phe Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Thr Glu Val Leu Arg Lys Gly Val Cys Thr Gly Trp Leu Ala Leu Leu 
                485                 490                 495     


Val Ala Ser Val Leu Gln Pro Asn Ile His Ala Ser His Glu Asp Ser 
            500                 505                 510         


Gly Lys Ala Leu Ala Pro Lys Ile Ser Ile Ser Pro Arg Thr Thr Asn 
        515                 520                 525             


Ser Phe His Leu Pro Asp Asp Pro Ser Ile Pro Ile Ile Met Val Gly 
    530                 535                 540                 


Pro Gly Thr Gly Ile Ala Pro Phe Ile Gly Phe Leu Gln His Arg Glu 
545                 550                 555                 560 


Lys Leu Gln Glu Gln His Pro Asp Gly Asn Phe Gly Ala Met Trp Leu 
                565                 570                 575     


Phe Phe Gly Cys Arg His Lys Asp Arg Asp Tyr Leu Phe Arg Lys Glu 
            580                 585                 590         


Leu Arg His Phe Leu Lys His Gly Ile Leu Thr His Leu Lys Val Ser 
        595                 600                 605             


Phe Ser Arg Asp Ala Pro Val Gly Glu Glu Glu Ala Pro Ala Lys Tyr 
    610                 615                 620                 


Val Gln Asp Asn Ile Gln Leu His Gly Gln Gln Val Ala Arg Ile Leu 
625                 630                 635                 640 


Leu Gln Glu Asn Gly His Ile Tyr Val Cys Gly Asp Ala Lys Asn Met 
                645                 650                 655     


Ala Lys Asp Val His Asp Ala Leu Val Gln Ile Ile Ser Lys Glu Val 
            660                 665                 670         


Gly Val Glu Lys Leu Glu Ala Met Lys Thr Leu Ala Thr Leu Lys Glu 
        675                 680                 685             


Glu Lys Arg Tyr Leu Gln Asp Ile Trp Ser 
    690                 695             


<210>  9049
<211>  372
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9049

Xaa Phe Thr Val Thr Cys Leu Glu Val Met Arg Arg Phe Leu Leu Leu 
1               5                   10                  15      


Tyr Ala Thr Gln Gln Gly Gln Ala Lys Ala Ile Ala Glu Glu Ile Cys 
            20                  25                  30          


Glu Gln Ala Val Val His Gly Phe Ser Ala Asp Leu His Cys Ile Ser 
        35                  40                  45              


Glu Ser Asp Lys Tyr Asp Leu Lys Thr Glu Thr Ala Pro Leu Val Val 
    50                  55                  60                  


Val Val Ser Thr Thr Gly Thr Gly Asp Pro Pro Asp Thr Ala Arg Lys 
65                  70                  75                  80  


Phe Val Lys Glu Ile Gln Asn Gln Thr Leu Pro Val Asp Phe Phe Ala 
                85                  90                  95      


His Leu Arg Tyr Gly Leu Leu Gly Leu Gly Asp Ser Glu Tyr Thr Tyr 
            100                 105                 110         


Phe Cys Asn Gly Gly Lys Ile Ile Asp Lys Arg Leu Gln Glu Leu Gly 
        115                 120                 125             


Ala Arg His Phe Tyr Asp Thr Gly His Ala Asp Asp Cys Val Gly Leu 
    130                 135                 140                 


Glu Leu Val Val Glu Pro Trp Ile Ala Gly Leu Trp Pro Ala Leu Arg 
145                 150                 155                 160 


Lys His Phe Arg Ser Ser Arg Gly Gln Glu Glu Ile Ser Gly Ala Leu 
                165                 170                 175     


Pro Val Ala Ser Pro Ala Ser Ser Arg Thr Asp Leu Val Lys Ser Glu 
            180                 185                 190         


Leu Leu His Ile Glu Ser Gln Val Glu Leu Leu Arg Phe Asp Asp Ser 
        195                 200                 205             


Gly Arg Lys Asp Ser Glu Val Leu Lys Gln Asn Ala Val Asn Ser Asn 
    210                 215                 220                 


Gln Ser Asn Val Val Ile Glu Asp Phe Glu Ser Ser Leu Thr Arg Ser 
225                 230                 235                 240 


Val Pro Pro Leu Ser Gln Ala Ser Leu Asn Ile Pro Gly Leu Pro Pro 
                245                 250                 255     


Glu Tyr Leu Gln Val His Leu Gln Glu Ser Leu Gly Gln Glu Glu Ser 
            260                 265                 270         


Gln Val Ser Val Thr Ser Ala Asp Pro Val Phe Gln Val Pro Ile Ser 
        275                 280                 285             


Lys Ala Val Gln Leu Thr Thr Asn Asp Ala Ile Lys Thr Thr Leu Leu 
    290                 295                 300                 


Val Glu Leu Asp Ile Ser Asn Thr Asp Phe Ser Tyr Gln Pro Gly Asp 
305                 310                 315                 320 


Ala Phe Ser Val Ile Cys Pro Asn Ser Asp Ser Glu Val Gln Ser Leu 
                325                 330                 335     


Leu Gln Arg Leu Gln Leu Glu Asp Lys Arg Glu His Cys Val Leu Leu 
            340                 345                 350         


Lys Ile Lys Ala Asp Thr Lys Lys Lys Gly Ile Phe Ala Ser Pro Cys 
        355                 360                 365             


Gly Leu Tyr Gln 
    370         


<210>  9050
<211>  160
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9050

Xaa Val Arg Ala Gly Ala Arg Leu Val Glu Val Ala Leu Cys Arg Phe 
1               5                   10                  15      


Val Pro Gly Trp Arg Gly Val Gly Leu Gly Asp Ser Glu Tyr Thr Tyr 
            20                  25                  30          


Phe Cys Asn Gly Gly Lys Ile Ile Asp Lys Arg Leu Gln Glu Leu Gly 
        35                  40                  45              


Ala Arg His Phe Tyr Asp Thr Gly His Ala Asp Asp Cys Val Gly Leu 
    50                  55                  60                  


Glu Leu Val Val Glu Pro Trp Ile Ala Gly Leu Trp Pro Ala Leu Arg 
65                  70                  75                  80  


Lys His Phe Arg Ser Ser Arg Gly Gln Glu Glu Ile Ser Gly Ala Leu 
                85                  90                  95      


Pro Val Ala Ser Pro Ala Ser Ser Arg Thr Asp Leu Val Lys Ser Glu 
            100                 105                 110         


Leu Leu His Ile Glu Ser Gln Val Glu Leu Leu Arg Phe Asp Asp Ser 
        115                 120                 125             


Gly Arg Lys Asp Ser Glu Val Leu Lys Gln Asn Ala Val Asn Ser Asn 
    130                 135                 140                 


Gln Ser Asn Val Val Ile Glu Asp Phe Glu Ser Ser Leu Thr Arg Ser 
145                 150                 155                 160 


<210>  9051
<211>  81
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9051

Xaa Val Arg Ala Gly Ala Arg Leu Val Glu Val Ala Leu Cys Ser Phe 
1               5                   10                  15      


Thr Val Thr Cys Leu Glu Val Met Arg Arg Phe Leu Leu Leu Tyr Ala 
            20                  25                  30          


Thr Gln Gln Gly Gln Ala Lys Ala Ile Ala Glu Glu Ile Cys Glu Gln 
        35                  40                  45              


Ala Val Val His Gly Phe Ser Ala Asp Leu His Cys Ile Ser Glu Ser 
    50                  55                  60                  


Asp Lys Val Ser Val Ile Gln Asn Thr Pro Thr Phe Ala Met Gly Gly 
65                  70                  75                  80  


Arg 
    


<210>  9052
<211>  115
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9052

Xaa Val Arg Ala Gly Ala Arg Leu Val Glu Val Ala Leu Cys Ser Phe 
1               5                   10                  15      


Thr Val Thr Cys Leu Glu Val Met Arg Arg Phe Leu Leu Leu Tyr Ala 
            20                  25                  30          


Thr Gln Gln Gly Gln Ala Lys Ala Ile Ala Glu Glu Ile Cys Glu Gln 
        35                  40                  45              


Ala Val Val His Gly Phe Ser Ala Asp Leu His Cys Ile Ser Glu Ser 
    50                  55                  60                  


Asp Lys Tyr Asp Leu Lys Thr Glu Thr Ala Pro Leu Val Val Val Val 
65                  70                  75                  80  


Ser Thr Thr Gly Thr Gly Asp Pro Pro Asp Thr Ala Arg Lys Phe Val 
                85                  90                  95      


Lys Glu Ile Gln Asn Gln Thr Leu Pro Val Asp Phe Phe Ala His Leu 
            100                 105                 110         


Arg Ser Arg 
        115 


<210>  9053
<211>  178
<212>  PRT
<213>  Homo Sapiens

<400>  9053

Met Ala Arg Ala Pro Leu Arg Pro Glu Asn Thr Ile Val Arg Gly Ser 
1               5                   10                  15      


Ala Asn Gln Cys Gln Asp Thr Tyr Arg Ala Glu Glu Leu Thr Gly His 
            20                  25                  30          


Thr Thr Gly Leu Ser Leu Asn Asn Asp Arg Leu Tyr Lys Leu Thr Tyr 
        35                  40                  45              


Ser Thr Glu Val Leu Leu Asp Arg Gly Lys Gly Lys Leu Gln Asp Ser 
    50                  55                  60                  


Val Gly Tyr Arg Ile Ser Ser Asn Val Asp Val Ala Leu Leu Trp Arg 
65                  70                  75                  80  


Asn Pro Asp Gly Asp Asp Asp Gln Leu Ile Gln Ile Thr Met Lys Asp 
                85                  90                  95      


Val Asn Val Glu Asn Val Asn Gln Gln Arg Gly Glu Lys Ser Ile Phe 
            100                 105                 110         


Lys Gly Lys Ser Pro Ser Lys Ile Met Gly Lys Glu Asn Leu Glu Ala 
        115                 120                 125             


Leu Gln Arg Pro Thr Leu Leu His Leu Ile His Gly Lys Val Lys Glu 
    130                 135                 140                 


Phe Tyr Ser Tyr Gln Asn Glu Ala Val Ala Ile Glu Asn Ile Lys Arg 
145                 150                 155                 160 


Gly Leu Ala Ser Leu Phe Gln Thr Gln Leu Ser Ser Gly Thr Thr Asn 
                165                 170                 175     


Glu Val 
        


<210>  9054
<211>  55
<212>  PRT
<213>  Homo Sapiens

<400>  9054

Met Ala Arg Ala Pro Leu Arg Pro Glu Asn Thr Ile Val Arg Gly Ser 
1               5                   10                  15      


Ala Asn Gln Cys Gln Asp Thr Tyr Arg Ala Glu Glu Leu Thr Gly Arg 
            20                  25                  30          


Pro Ser Ile Ile Thr Arg Ile His Lys Thr Glu Glu Gly Asp Arg Arg 
        35                  40                  45              


Asp Gly Gln Ser Asp Met Lys 
    50                  55  


<210>  9055
<211>  42
<212>  PRT
<213>  Homo Sapiens

<400>  9055

Met Ala Arg Ala Pro Leu Arg Pro Glu Asn Thr Ile Val Arg Gly Ser 
1               5                   10                  15      


Ala Asn Gln Cys Gln Asp Thr Tyr Arg Ala Glu Glu Leu Thr Gly Ser 
            20                  25                  30          


Glu Glu Gly His Ser Leu Thr Gly Cys His 
        35                  40          


<210>  9056
<211>  56
<212>  PRT
<213>  Homo Sapiens

<400>  9056

Met Glu Glu Arg Gly Gly Val Tyr Ala Gly Arg Gly Leu Glu Leu Val 
1               5                   10                  15      


Phe Trp Glu Trp Glu Val Val Thr Val Met Ser Val Phe Ser Arg Ser 
            20                  25                  30          


Arg Ile Lys Cys Val Pro Ala Asp Val Tyr Ser Phe Ile Tyr Ser Cys 
        35                  40                  45              


Glu Tyr Trp Met Lys Glu Leu Arg 
    50                  55      


<210>  9057
<211>  921
<212>  PRT
<213>  Homo Sapiens

<400>  9057

Met Glu Glu Arg Gly Gly Val Tyr Ala Gly Arg Gly Leu Glu Leu Val 
1               5                   10                  15      


Phe Trp Glu Trp Glu Val Val Thr Val Met Ser Val Phe Ser Arg Ser 
            20                  25                  30          


Arg Ile Lys Cys Val Pro Ala Asp Val Tyr Ser Phe Ile Tyr Ser Cys 
        35                  40                  45              


His Thr Thr Gly Leu Ser Leu Asn Asn Asp Arg Leu Tyr Lys Leu Thr 
    50                  55                  60                  


Tyr Ser Thr Glu Val Leu Leu Asp Arg Gly Lys Gly Lys Leu Gln Asp 
65                  70                  75                  80  


Ser Val Gly Tyr Arg Ile Ser Ser Asn Val Asp Val Ala Leu Leu Trp 
                85                  90                  95      


Arg Asn Pro Asp Gly Asp Asp Asp Gln Leu Ile Gln Ile Thr Met Lys 
            100                 105                 110         


Asp Val Asn Val Glu Asn Val Asn Gln Gln Arg Gly Glu Lys Ser Ile 
        115                 120                 125             


Phe Lys Gly Lys Ser Pro Ser Lys Ile Met Gly Lys Glu Asn Leu Glu 
    130                 135                 140                 


Ala Leu Gln Arg Pro Thr Leu Leu His Leu Ile His Gly Lys Val Lys 
145                 150                 155                 160 


Glu Phe Tyr Ser Tyr Gln Asn Glu Ala Val Ala Ile Glu Asn Ile Lys 
                165                 170                 175     


Arg Gly Leu Ala Ser Leu Phe Gln Thr Gln Leu Ser Ser Gly Thr Thr 
            180                 185                 190         


Asn Glu Val Asp Ile Ser Gly Asn Cys Lys Val Thr Tyr Gln Ala His 
        195                 200                 205             


Gln Asp Lys Val Ile Lys Ile Lys Ala Leu Asp Ser Cys Lys Ile Ala 
    210                 215                 220                 


Arg Ser Gly Phe Thr Thr Pro Asn Gln Val Leu Gly Val Ser Ser Lys 
225                 230                 235                 240 


Ala Thr Ser Val Thr Thr Tyr Lys Ile Glu Asp Ser Phe Val Ile Ala 
                245                 250                 255     


Val Leu Ala Glu Glu Thr His Asn Phe Gly Leu Asn Phe Leu Gln Thr 
            260                 265                 270         


Ile Lys Gly Lys Ile Val Ser Lys Gln Lys Leu Glu Leu Lys Thr Thr 
        275                 280                 285             


Glu Ala Gly Pro Arg Leu Met Ser Gly Lys Gln Ala Ala Ala Ile Ile 
    290                 295                 300                 


Lys Ala Val Asp Ser Lys Tyr Thr Ala Ile Pro Ile Val Gly Gln Val 
305                 310                 315                 320 


Phe Gln Ser His Cys Lys Gly Cys Pro Ser Leu Ser Glu Leu Trp Arg 
                325                 330                 335     


Ser Thr Arg Lys Tyr Leu Gln Pro Asp Asn Leu Ser Lys Ala Glu Ala 
            340                 345                 350         


Val Arg Asn Phe Leu Ala Phe Ile Gln His Leu Arg Thr Ala Lys Lys 
        355                 360                 365             


Glu Glu Ile Leu Gln Ile Leu Lys Met Glu Asn Lys Glu Val Leu Pro 
    370                 375                 380                 


Gln Leu Val Asp Ala Val Thr Ser Ala Gln Thr Ser Asp Ser Leu Glu 
385                 390                 395                 400 


Ala Ile Leu Asp Phe Leu Asp Phe Lys Ser Asp Ser Ser Ile Ile Leu 
                405                 410                 415     


Gln Glu Arg Phe Leu Tyr Ala Cys Gly Phe Ala Ser His Pro Asn Glu 
            420                 425                 430         


Glu Leu Leu Arg Ala Leu Ile Ser Lys Phe Lys Gly Ser Ile Gly Ser 
        435                 440                 445             


Ser Asp Ile Arg Glu Thr Val Met Ile Ile Thr Gly Thr Leu Val Arg 
    450                 455                 460                 


Lys Leu Cys Gln Asn Glu Gly Cys Lys Leu Lys Ala Val Val Glu Ala 
465                 470                 475                 480 


Lys Lys Leu Ile Leu Gly Gly Leu Glu Lys Ala Glu Lys Lys Glu Asp 
                485                 490                 495     


Thr Arg Met Tyr Leu Leu Ala Leu Lys Asn Ala Leu Leu Pro Glu Gly 
            500                 505                 510         


Ile Pro Ser Leu Leu Lys Tyr Ala Glu Ala Gly Glu Gly Pro Ile Ser 
        515                 520                 525             


His Leu Ala Thr Thr Ala Leu Gln Arg Tyr Asp Leu Pro Phe Ile Thr 
    530                 535                 540                 


Asp Glu Val Lys Lys Thr Leu Asn Arg Ile Tyr His Gln Asn Arg Lys 
545                 550                 555                 560 


Val His Glu Lys Thr Val Arg Thr Ala Ala Ala Ala Ile Ile Leu Asn 
                565                 570                 575     


Asn Asn Pro Ser Tyr Met Asp Val Lys Asn Ile Leu Leu Ser Ile Gly 
            580                 585                 590         


Glu Leu Pro Gln Glu Met Asn Lys Tyr Met Leu Ala Ile Val Gln Asp 
        595                 600                 605             


Ile Leu Arg Phe Glu Met Pro Ala Ser Lys Ile Val Arg Arg Val Leu 
    610                 615                 620                 


Lys Glu Met Val Ala His Asn Tyr Asp Arg Phe Ser Arg Ser Gly Ser 
625                 630                 635                 640 


Ser Ser Ala Tyr Thr Gly Tyr Ile Glu Arg Ser Pro Arg Ser Ala Ser 
                645                 650                 655     


Thr Tyr Ser Leu Asp Ile Leu Tyr Ser Gly Ser Gly Ile Leu Arg Arg 
            660                 665                 670         


Ser Asn Leu Asn Ile Phe Gln Tyr Ile Gly Lys Ala Gly Leu His Gly 
        675                 680                 685             


Ser Gln Val Val Ile Glu Ala Gln Gly Leu Glu Ala Leu Ile Ala Ala 
    690                 695                 700                 


Thr Pro Asp Glu Gly Glu Glu Asn Leu Asp Ser Tyr Ala Gly Met Ser 
705                 710                 715                 720 


Ala Ile Leu Phe Asp Val Gln Leu Arg Pro Val Thr Phe Phe Asn Gly 
                725                 730                 735     


Tyr Ser Asp Leu Met Ser Lys Met Leu Ser Ala Ser Gly Asp Pro Ile 
            740                 745                 750         


Ser Val Val Lys Gly Leu Ile Leu Leu Ile Asp His Ser Gln Glu Leu 
        755                 760                 765             


Gln Leu Gln Ser Gly Leu Lys Ala Asn Ile Glu Val Gln Gly Gly Leu 
    770                 775                 780                 


Ala Ile Asp Ile Ser Gly Ala Met Glu Phe Ser Leu Trp Tyr Arg Glu 
785                 790                 795                 800 


Ser Lys Thr Arg Val Lys Asn Arg Val Thr Val Val Ile Thr Thr Asp 
                805                 810                 815     


Ile Thr Val Asp Ser Ser Phe Val Lys Ala Gly Leu Glu Thr Ser Thr 
            820                 825                 830         


Glu Thr Glu Ala Gly Leu Glu Phe Ile Ser Thr Val Gln Phe Ser Gln 
        835                 840                 845             


Tyr Pro Phe Leu Val Cys Met Gln Met Asp Lys Asp Glu Ala Pro Phe 
    850                 855                 860                 


Arg Gln Phe Glu Lys Lys Tyr Glu Arg Leu Ser Thr Gly Arg Gly Tyr 
865                 870                 875                 880 


Val Ser Gln Lys Arg Lys Glu Ser Val Leu Ala Gly Cys Glu Phe Pro 
                885                 890                 895     


Leu His Gln Glu Asn Ser Glu Met Cys Lys Val Val Phe Ala Pro Gln 
            900                 905                 910         


Pro Asp Ser Thr Ser Ser Gly Trp Phe 
        915                 920     


<210>  9058
<211>  50
<212>  PRT
<213>  Homo Sapiens

<400>  9058

Met Glu Glu Arg Gly Gly Val Tyr Ala Gly Arg Gly Leu Glu Leu Val 
1               5                   10                  15      


Phe Trp Glu Trp Glu Val Val Thr Val Met Ser Val Phe Ser Arg Ser 
            20                  25                  30          


Arg Ile Lys Cys Val Pro Ala Asp Val Tyr Ser Phe Ile Tyr Ser Cys 
        35                  40                  45              


Pro Val 
    50  


<210>  9059
<211>  72
<212>  PRT
<213>  Homo Sapiens

<400>  9059

Met Glu Glu Arg Gly Gly Val Tyr Ala Gly Arg Gly Leu Glu Leu Val 
1               5                   10                  15      


Phe Trp Glu Trp Glu Val Val Thr Val Met Ser Val Phe Ser Arg Ser 
            20                  25                  30          


Arg Ile Lys Cys Val Pro Ala Asp Val Tyr Ser Phe Ile Tyr Ser Cys 
        35                  40                  45              


Arg Pro Ser Ile Ile Thr Arg Ile His Lys Thr Glu Glu Gly Asp Arg 
    50                  55                  60                  


Arg Asp Gly Gln Ser Asp Met Lys 
65                  70          


<210>  9060
<211>  59
<212>  PRT
<213>  Homo Sapiens

<400>  9060

Met Glu Glu Arg Gly Gly Val Tyr Ala Gly Arg Gly Leu Glu Leu Val 
1               5                   10                  15      


Phe Trp Glu Trp Glu Val Val Thr Val Met Ser Val Phe Ser Arg Ser 
            20                  25                  30          


Arg Ile Lys Cys Val Pro Ala Asp Val Tyr Ser Phe Ile Tyr Ser Cys 
        35                  40                  45              


Ser Glu Glu Gly His Ser Leu Thr Gly Cys His 
    50                  55                  


<210>  9061
<211>  894
<212>  PRT
<213>  Homo Sapiens

<400>  9061

Met Ile Leu Leu Ala Val Leu Phe Leu Cys Phe Ile Ser Ser Tyr Ser 
1               5                   10                  15      


Ala Ser Val Lys Gly His Thr Thr Gly Leu Ser Leu Asn Asn Asp Arg 
            20                  25                  30          


Leu Tyr Lys Leu Thr Tyr Ser Thr Glu Val Leu Leu Asp Arg Gly Lys 
        35                  40                  45              


Gly Lys Leu Gln Asp Ser Val Gly Tyr Arg Ile Ser Ser Asn Val Asp 
    50                  55                  60                  


Val Ala Leu Leu Trp Arg Asn Pro Asp Gly Asp Asp Asp Gln Leu Ile 
65                  70                  75                  80  


Gln Ile Thr Met Lys Asp Val Asn Val Glu Asn Val Asn Gln Gln Arg 
                85                  90                  95      


Gly Glu Lys Ser Ile Phe Lys Gly Lys Ser Pro Ser Lys Ile Met Gly 
            100                 105                 110         


Lys Glu Asn Leu Glu Ala Leu Gln Arg Pro Thr Leu Leu His Leu Ile 
        115                 120                 125             


His Gly Lys Val Lys Glu Phe Tyr Ser Tyr Gln Asn Glu Ala Val Ala 
    130                 135                 140                 


Ile Glu Asn Ile Lys Arg Gly Leu Ala Ser Leu Phe Gln Thr Gln Leu 
145                 150                 155                 160 


Ser Ser Gly Thr Thr Asn Glu Val Asp Ile Ser Gly Asn Cys Lys Val 
                165                 170                 175     


Thr Tyr Gln Ala His Gln Asp Lys Val Ile Lys Ile Lys Ala Leu Asp 
            180                 185                 190         


Ser Cys Lys Ile Ala Arg Ser Gly Phe Thr Thr Pro Asn Gln Val Leu 
        195                 200                 205             


Gly Val Ser Ser Lys Ala Thr Ser Val Thr Thr Tyr Lys Ile Glu Asp 
    210                 215                 220                 


Ser Phe Val Ile Ala Val Leu Ala Glu Glu Thr His Asn Phe Gly Leu 
225                 230                 235                 240 


Asn Phe Leu Gln Thr Ile Lys Gly Lys Ile Val Ser Lys Gln Lys Leu 
                245                 250                 255     


Glu Leu Lys Thr Thr Glu Ala Gly Pro Arg Leu Met Ser Gly Lys Gln 
            260                 265                 270         


Ala Ala Ala Ile Ile Lys Ala Val Asp Ser Lys Tyr Thr Ala Ile Pro 
        275                 280                 285             


Ile Val Gly Gln Val Phe Gln Ser His Cys Lys Gly Cys Pro Ser Leu 
    290                 295                 300                 


Ser Glu Leu Trp Arg Ser Thr Arg Lys Tyr Leu Gln Pro Asp Asn Leu 
305                 310                 315                 320 


Ser Lys Ala Glu Ala Val Arg Asn Phe Leu Ala Phe Ile Gln His Leu 
                325                 330                 335     


Arg Thr Ala Lys Lys Glu Glu Ile Leu Gln Ile Leu Lys Met Glu Asn 
            340                 345                 350         


Lys Glu Val Leu Pro Gln Leu Val Asp Ala Val Thr Ser Ala Gln Thr 
        355                 360                 365             


Ser Asp Ser Leu Glu Ala Ile Leu Asp Phe Leu Asp Phe Lys Ser Asp 
    370                 375                 380                 


Ser Ser Ile Ile Leu Gln Glu Arg Phe Leu Tyr Ala Cys Gly Phe Ala 
385                 390                 395                 400 


Ser His Pro Asn Glu Glu Leu Leu Arg Ala Leu Ile Ser Lys Phe Lys 
                405                 410                 415     


Gly Ser Ile Gly Ser Ser Asp Ile Arg Glu Thr Val Met Ile Ile Thr 
            420                 425                 430         


Gly Thr Leu Val Arg Lys Leu Cys Gln Asn Glu Gly Cys Lys Leu Lys 
        435                 440                 445             


Ala Val Val Glu Ala Lys Lys Leu Ile Leu Gly Gly Leu Glu Lys Ala 
    450                 455                 460                 


Glu Lys Lys Glu Asp Thr Arg Met Tyr Leu Leu Ala Leu Lys Asn Ala 
465                 470                 475                 480 


Leu Leu Pro Glu Gly Ile Pro Ser Leu Leu Lys Tyr Ala Glu Ala Gly 
                485                 490                 495     


Glu Gly Pro Ile Ser His Leu Ala Thr Thr Ala Leu Gln Arg Tyr Asp 
            500                 505                 510         


Leu Pro Phe Ile Thr Asp Glu Val Lys Lys Thr Leu Asn Arg Ile Tyr 
        515                 520                 525             


His Gln Asn Arg Lys Val His Glu Lys Thr Val Arg Thr Ala Ala Ala 
    530                 535                 540                 


Ala Ile Ile Leu Asn Asn Asn Pro Ser Tyr Met Asp Val Lys Asn Ile 
545                 550                 555                 560 


Leu Leu Ser Ile Gly Glu Leu Pro Gln Glu Met Asn Lys Tyr Met Leu 
                565                 570                 575     


Ala Ile Val Gln Asp Ile Leu Arg Phe Glu Met Pro Ala Ser Lys Ile 
            580                 585                 590         


Val Arg Arg Val Leu Lys Glu Met Val Ala His Asn Tyr Asp Arg Phe 
        595                 600                 605             


Ser Arg Ser Gly Ser Ser Ser Ala Tyr Thr Gly Tyr Ile Glu Arg Ser 
    610                 615                 620                 


Pro Arg Ser Ala Ser Thr Tyr Ser Leu Asp Ile Leu Tyr Ser Gly Ser 
625                 630                 635                 640 


Gly Ile Leu Arg Arg Ser Asn Leu Asn Ile Phe Gln Tyr Ile Gly Lys 
                645                 650                 655     


Ala Gly Leu His Gly Ser Gln Val Val Ile Glu Ala Gln Gly Leu Glu 
            660                 665                 670         


Ala Leu Ile Ala Ala Thr Pro Asp Glu Gly Glu Glu Asn Leu Asp Ser 
        675                 680                 685             


Tyr Ala Gly Met Ser Ala Ile Leu Phe Asp Val Gln Leu Arg Pro Val 
    690                 695                 700                 


Thr Phe Phe Asn Gly Tyr Ser Asp Leu Met Ser Lys Met Leu Ser Ala 
705                 710                 715                 720 


Ser Gly Asp Pro Ile Ser Val Val Lys Gly Leu Ile Leu Leu Ile Asp 
                725                 730                 735     


His Ser Gln Glu Leu Gln Leu Gln Ser Gly Leu Lys Ala Asn Ile Glu 
            740                 745                 750         


Val Gln Gly Gly Leu Ala Ile Asp Ile Ser Gly Ala Met Glu Phe Ser 
        755                 760                 765             


Leu Trp Tyr Arg Glu Ser Lys Thr Arg Val Lys Asn Arg Val Thr Val 
    770                 775                 780                 


Val Ile Thr Thr Asp Ile Thr Val Asp Ser Ser Phe Val Lys Ala Gly 
785                 790                 795                 800 


Leu Glu Thr Ser Thr Glu Thr Glu Ala Gly Leu Glu Phe Ile Ser Thr 
                805                 810                 815     


Val Gln Phe Ser Gln Tyr Pro Phe Leu Val Cys Met Gln Met Asp Lys 
            820                 825                 830         


Asp Glu Ala Pro Phe Arg Gln Phe Glu Lys Lys Tyr Glu Arg Leu Ser 
        835                 840                 845             


Thr Gly Arg Gly Tyr Val Ser Gln Lys Arg Lys Glu Ser Val Leu Ala 
    850                 855                 860                 


Gly Cys Glu Phe Pro Leu His Gln Glu Asn Ser Glu Met Cys Lys Val 
865                 870                 875                 880 


Val Phe Ala Pro Gln Pro Asp Ser Thr Ser Ser Gly Trp Phe 
                885                 890                 


<210>  9062
<211>  894
<212>  PRT
<213>  Homo Sapiens

<400>  9062

Met Ile Leu Leu Ala Val Leu Phe Leu Cys Phe Ile Ser Ser Tyr Ser 
1               5                   10                  15      


Ala Ser Val Lys Gly His Thr Thr Gly Leu Ser Leu Asn Asn Asp Arg 
            20                  25                  30          


Leu Tyr Lys Leu Thr Tyr Ser Thr Glu Val Leu Leu Asp Arg Gly Lys 
        35                  40                  45              


Gly Lys Leu Gln Asp Ser Val Gly Tyr Arg Ile Ser Ser Asn Val Asp 
    50                  55                  60                  


Val Ala Leu Leu Trp Arg Asn Pro Asp Gly Asp Asp Asp Gln Leu Ile 
65                  70                  75                  80  


Gln Ile Thr Met Lys Asp Val Asn Val Glu Asn Val Asn Gln Gln Arg 
                85                  90                  95      


Gly Glu Lys Ser Ile Phe Lys Gly Lys Ser Pro Ser Lys Ile Met Gly 
            100                 105                 110         


Lys Glu Asn Leu Glu Ala Leu Gln Arg Pro Thr Leu Leu His Leu Ile 
        115                 120                 125             


His Gly Lys Val Lys Glu Phe Tyr Ser Tyr Gln Asn Glu Ala Val Ala 
    130                 135                 140                 


Ile Glu Asn Ile Lys Arg Gly Leu Ala Ser Leu Phe Gln Thr Gln Leu 
145                 150                 155                 160 


Ser Ser Gly Thr Thr Asn Glu Val Asp Ile Ser Gly Asn Cys Lys Val 
                165                 170                 175     


Thr Tyr Gln Ala His Gln Asp Lys Val Ile Lys Ile Lys Ala Leu Asp 
            180                 185                 190         


Ser Cys Lys Ile Ala Arg Ser Gly Phe Thr Thr Pro Asn Gln Val Leu 
        195                 200                 205             


Gly Val Ser Ser Lys Ala Thr Ser Val Thr Thr Tyr Lys Ile Glu Asp 
    210                 215                 220                 


Ser Phe Val Ile Ala Val Leu Ala Glu Glu Thr His Asn Phe Gly Leu 
225                 230                 235                 240 


Asn Phe Leu Gln Thr Ile Lys Gly Lys Ile Val Ser Lys Gln Lys Leu 
                245                 250                 255     


Glu Leu Lys Thr Thr Glu Ala Gly Pro Arg Leu Met Ser Gly Lys Gln 
            260                 265                 270         


Ala Ala Ala Ile Ile Lys Ala Val Asp Ser Lys Tyr Thr Ala Ile Pro 
        275                 280                 285             


Ile Val Gly Gln Val Phe Gln Ser His Cys Lys Gly Cys Pro Ser Leu 
    290                 295                 300                 


Ser Glu Leu Trp Arg Ser Thr Arg Lys Tyr Leu Gln Pro Asp Asn Leu 
305                 310                 315                 320 


Ser Lys Ala Glu Ala Val Arg Asn Phe Leu Ala Phe Ile Gln His Leu 
                325                 330                 335     


Arg Thr Ala Lys Lys Glu Glu Ile Leu Gln Ile Leu Lys Met Glu Asn 
            340                 345                 350         


Lys Glu Val Leu Pro Gln Leu Val Asp Ala Val Thr Ser Ala Gln Thr 
        355                 360                 365             


Ser Asp Ser Leu Glu Ala Ile Leu Asp Phe Leu Asp Phe Lys Ser Asp 
    370                 375                 380                 


Ser Ser Ile Ile Leu Gln Glu Arg Phe Leu Tyr Ala Cys Gly Phe Ala 
385                 390                 395                 400 


Ser His Pro Asn Glu Glu Leu Leu Arg Ala Leu Ile Ser Lys Phe Lys 
                405                 410                 415     


Gly Ser Ile Gly Ser Ser Asp Ile Arg Glu Thr Val Met Ile Ile Thr 
            420                 425                 430         


Gly Thr Leu Val Arg Lys Leu Cys Gln Asn Glu Gly Cys Lys Leu Lys 
        435                 440                 445             


Ala Val Val Glu Ala Lys Lys Leu Ile Leu Gly Gly Leu Glu Lys Ala 
    450                 455                 460                 


Glu Lys Lys Glu Asp Thr Arg Met Tyr Leu Leu Ala Leu Lys Asn Ala 
465                 470                 475                 480 


Leu Leu Pro Glu Gly Ile Pro Ser Leu Leu Lys Tyr Ala Glu Ala Gly 
                485                 490                 495     


Glu Gly Pro Ile Ser His Leu Ala Thr Thr Ala Leu Gln Arg Tyr Asp 
            500                 505                 510         


Leu Pro Phe Ile Thr Asp Glu Val Lys Lys Thr Leu Asn Arg Ile Tyr 
        515                 520                 525             


His Gln Asn Arg Lys Val His Glu Lys Thr Val Arg Thr Ala Ala Ala 
    530                 535                 540                 


Ala Ile Ile Leu Asn Asn Asn Pro Ser Tyr Met Asp Val Lys Asn Ile 
545                 550                 555                 560 


Leu Leu Ser Ile Gly Glu Leu Pro Gln Glu Met Asn Lys Tyr Met Leu 
                565                 570                 575     


Ala Ile Val Gln Asp Ile Leu Arg Phe Glu Met Pro Ala Ser Lys Ile 
            580                 585                 590         


Val Arg Arg Val Leu Lys Glu Met Val Ala His Asn Tyr Asp Arg Phe 
        595                 600                 605             


Ser Arg Ser Gly Ser Ser Ser Ala Tyr Thr Gly Tyr Ile Glu Arg Ser 
    610                 615                 620                 


Pro Arg Ser Ala Ser Thr Tyr Ser Leu Asp Ile Leu Tyr Ser Gly Ser 
625                 630                 635                 640 


Gly Ile Leu Arg Arg Ser Asn Leu Asn Ile Phe Gln Tyr Ile Gly Lys 
                645                 650                 655     


Ala Gly Leu His Gly Ser Gln Val Val Ile Glu Ala Gln Gly Leu Glu 
            660                 665                 670         


Ala Leu Ile Ala Ala Thr Pro Asp Glu Gly Glu Glu Asn Leu Asp Ser 
        675                 680                 685             


Tyr Ala Gly Met Ser Ala Ile Leu Phe Asp Val Gln Leu Arg Pro Val 
    690                 695                 700                 


Thr Phe Phe Asn Gly Tyr Ser Asp Leu Met Ser Lys Met Leu Ser Ala 
705                 710                 715                 720 


Ser Gly Asp Pro Ile Ser Val Val Lys Gly Leu Ile Leu Leu Ile Asp 
                725                 730                 735     


His Ser Gln Glu Leu Gln Leu Gln Ser Gly Leu Lys Ala Asn Ile Glu 
            740                 745                 750         


Val Gln Gly Gly Leu Ala Ile Asp Ile Ser Gly Ala Met Glu Phe Ser 
        755                 760                 765             


Leu Trp Tyr Arg Glu Ser Lys Thr Arg Val Lys Asn Arg Val Thr Val 
    770                 775                 780                 


Val Ile Thr Thr Asp Ile Thr Val Asp Ser Ser Phe Val Lys Ala Gly 
785                 790                 795                 800 


Leu Glu Thr Ser Thr Glu Thr Glu Ala Gly Leu Glu Phe Ile Ser Thr 
                805                 810                 815     


Val Gln Phe Ser Gln Tyr Pro Phe Leu Val Cys Met Gln Met Asp Lys 
            820                 825                 830         


Asp Glu Ala Pro Phe Arg Gln Phe Glu Lys Lys Tyr Glu Arg Leu Ser 
        835                 840                 845             


Thr Gly Arg Gly Tyr Val Ser Gln Lys Arg Lys Glu Ser Val Leu Ala 
    850                 855                 860                 


Gly Cys Glu Phe Pro Leu His Gln Glu Asn Ser Glu Met Cys Lys Val 
865                 870                 875                 880 


Val Phe Ala Pro Gln Pro Asp Ser Thr Ser Ser Gly Trp Phe 
                885                 890                 


<210>  9063
<211>  151
<212>  PRT
<213>  Homo Sapiens

<400>  9063

Met Ile Leu Leu Ala Val Leu Phe Leu Cys Phe Ile Ser Ser Tyr Ser 
1               5                   10                  15      


Ala Ser Val Lys Gly His Thr Thr Gly Leu Ser Leu Asn Asn Asp Arg 
            20                  25                  30          


Leu Tyr Lys Leu Thr Tyr Ser Thr Glu Val Leu Leu Asp Arg Gly Lys 
        35                  40                  45              


Gly Lys Leu Gln Asp Ser Val Gly Tyr Arg Ile Ser Ser Asn Val Asp 
    50                  55                  60                  


Val Ala Leu Leu Trp Arg Asn Pro Asp Gly Asp Asp Asp Gln Leu Ile 
65                  70                  75                  80  


Gln Ile Thr Met Lys Asp Val Asn Val Glu Asn Val Asn Gln Gln Arg 
                85                  90                  95      


Gly Glu Lys Ser Ile Phe Lys Gly Lys Ser Pro Ser Lys Ile Met Gly 
            100                 105                 110         


Lys Glu Asn Leu Glu Ala Leu Gln Arg Pro Thr Leu Leu His Leu Ile 
        115                 120                 125             


His Gly Lys Val Lys Gly Arg Leu Asp Ser Thr Thr Phe Ser Pro Thr 
    130                 135                 140                 


Ser Tyr Phe Ser Ser Leu Gln 
145                 150     


<210>  9064
<211>  45
<212>  PRT
<213>  Homo Sapiens

<400>  9064

Met Ser Leu Val Ala Glu Ala Phe Val Ser Gln Ile Ala Ala Ala Glu 
1               5                   10                  15      


Pro Trp Pro Glu Asn Ala Thr Leu Tyr Gln Gln Leu Lys Gly Glu Gln 
            20                  25                  30          


Ile Leu Leu Ser Asp Asn Ala Ala Ser Leu Ala Val Gln 
        35                  40                  45  


<210>  9065
<211>  263
<212>  PRT
<213>  Homo Sapiens

<400>  9065

Met Ser Leu Val Ala Glu Ala Phe Val Ser Gln Ile Ala Ala Ala Glu 
1               5                   10                  15      


Pro Trp Pro Glu Asn Ala Thr Leu Tyr Gln Gln Leu Lys Gly Glu Gln 
            20                  25                  30          


Ile Leu Leu Ser Asp Asn Ala Ala Ser Leu Ala Val Gln Ala Phe Leu 
        35                  40                  45              


Gln Met Cys Asn Leu Pro Ile Lys Val Val Cys Arg Ala Asn Ala Glu 
    50                  55                  60                  


Tyr Met Ser Pro Ser Gly Lys Val Pro Phe Ile His Val Gly Asn Gln 
65                  70                  75                  80  


Val Val Ser Glu Leu Gly Pro Ile Val Gln Phe Val Lys Ala Lys Gly 
                85                  90                  95      


His Ser Leu Ser Asp Gly Leu Glu Glu Val Gln Lys Ala Glu Met Lys 
            100                 105                 110         


Ala Tyr Met Glu Leu Val Asn Asn Met Leu Leu Thr Ala Glu Leu Tyr 
        115                 120                 125             


Leu Gln Trp Cys Asp Glu Ala Thr Val Gly Glu Ile Thr His Ala Arg 
    130                 135                 140                 


Tyr Gly Ser Pro Tyr Pro Trp Pro Leu Asn His Ile Leu Ala Tyr Gln 
145                 150                 155                 160 


Lys Gln Trp Glu Val Lys Arg Lys Met Lys Ala Ile Gly Trp Gly Lys 
                165                 170                 175     


Lys Thr Leu Asp Gln Val Leu Glu Asp Val Asp Gln Cys Cys Gln Ala 
            180                 185                 190         


Leu Ser Gln Arg Leu Gly Thr Gln Pro Tyr Phe Phe Asn Lys Gln Pro 
        195                 200                 205             


Thr Glu Leu Asp Ala Leu Val Phe Gly His Leu Tyr Thr Ile Leu Thr 
    210                 215                 220                 


Thr Gln Leu Thr Asn Asp Glu Leu Ser Glu Lys Val Lys Asn Tyr Ser 
225                 230                 235                 240 


Asn Leu Leu Ala Phe Cys Arg Arg Ile Glu Gln His Tyr Phe Glu Asp 
                245                 250                 255     


Arg Gly Lys Gly Arg Leu Ser 
            260             


<210>  9066
<211>  229
<212>  PRT
<213>  Homo Sapiens

<400>  9066

Met Ser Leu Val Ala Glu Ala Phe Val Ser Gln Ile Ala Ala Ala Glu 
1               5                   10                  15      


Pro Trp Pro Glu Asn Ala Thr Leu Tyr Gln Gln Leu Lys Gly Glu Gln 
            20                  25                  30          


Ile Leu Leu Ser Asp Asn Ala Ala Ser Leu Ala Val Gln Ala Phe Leu 
        35                  40                  45              


Gln Met Cys Asn Leu Pro Ile Lys Val Val Cys Arg Ala Asn Ala Glu 
    50                  55                  60                  


Tyr Met Ser Pro Ser Gly Lys Val Pro Phe Ile His Val Gly Asn Gln 
65                  70                  75                  80  


Val Val Ser Glu Leu Gly Pro Ile Val Gln Phe Val Lys Ala Lys Gly 
                85                  90                  95      


His Ser Leu Ser Asp Gly Leu Glu Glu Val Gln Lys Ala Glu Met Lys 
            100                 105                 110         


Ala Tyr Met Glu Leu Val Asn Asn Met Leu Leu Thr Ala Glu Leu Tyr 
        115                 120                 125             


Leu Gln Trp Cys Asp Glu Ala Thr Val Gly Glu Trp Glu Val Lys Arg 
    130                 135                 140                 


Lys Met Lys Ala Ile Gly Trp Gly Lys Lys Thr Leu Asp Gln Val Leu 
145                 150                 155                 160 


Glu Asp Val Asp Gln Cys Cys Gln Ala Leu Ser Gln Arg Leu Gly Thr 
                165                 170                 175     


Gln Pro Tyr Phe Phe Asn Lys Gln Pro Thr Glu Leu Asp Ala Leu Val 
            180                 185                 190         


Phe Gly His Leu Tyr Thr Ile Leu Thr Thr Gln Leu Thr Asn Asp Glu 
        195                 200                 205             


Leu Ser Glu Lys Val Lys Asn Tyr Ser Asn Leu Leu Ala Phe Cys Arg 
    210                 215                 220                 


Arg Ile Glu Gln His 
225                 


<210>  9067
<211>  207
<212>  PRT
<213>  Homo Sapiens

<400>  9067

Met Ser Leu Val Ala Glu Ala Phe Val Ser Gln Ile Ala Gly Lys Val 
1               5                   10                  15      


Pro Phe Ile His Val Gly Asn Gln Val Val Ser Glu Leu Gly Pro Ile 
            20                  25                  30          


Val Gln Phe Val Lys Ala Lys Gly His Ser Leu Ser Asp Gly Leu Glu 
        35                  40                  45              


Glu Val Gln Lys Ala Glu Met Lys Ala Tyr Met Glu Leu Val Asn Asn 
    50                  55                  60                  


Met Leu Leu Thr Ala Glu Leu Tyr Leu Gln Trp Cys Asp Glu Ala Thr 
65                  70                  75                  80  


Val Gly Glu Ile Thr His Ala Arg Tyr Gly Ser Pro Tyr Pro Trp Pro 
                85                  90                  95      


Leu Asn His Ile Leu Ala Tyr Gln Lys Gln Trp Glu Val Lys Arg Lys 
            100                 105                 110         


Met Lys Ala Ile Gly Trp Gly Lys Lys Thr Leu Asp Gln Val Leu Glu 
        115                 120                 125             


Asp Val Asp Gln Cys Cys Gln Ala Leu Ser Gln Arg Leu Gly Thr Gln 
    130                 135                 140                 


Pro Tyr Phe Phe Asn Lys Gln Pro Thr Glu Leu Asp Ala Leu Val Phe 
145                 150                 155                 160 


Gly His Leu Tyr Thr Ile Leu Thr Thr Gln Leu Thr Asn Asp Glu Leu 
                165                 170                 175     


Ser Glu Lys Val Lys Asn Tyr Ser Asn Leu Leu Ala Phe Cys Arg Arg 
            180                 185                 190         


Ile Glu Gln His Tyr Phe Glu Asp Arg Gly Lys Gly Arg Leu Ser 
        195                 200                 205         


<210>  9068
<211>  37
<212>  PRT
<213>  Homo Sapiens

<400>  9068

Met Ser Leu Val Ala Glu Ala Phe Val Ser Gln Ile Ala Gly Trp Ser 
1               5                   10                  15      


Ala Val Ala Gln Pro Gly Leu Thr Ala Thr Ser Ala Ser Arg Val Gln 
            20                  25                  30          


Ala Ile Leu Leu Pro 
        35          


<210>  9069
<211>  228
<212>  PRT
<213>  Homo Sapiens

<400>  9069

Ala Ser Ser Thr His His Ser Thr Val Pro Pro Leu Thr Ser Ser Asn 
1               5                   10                  15      


His Ser Thr Ser Pro Gln Leu Ser Thr Gly Val Ser Phe Phe Phe Leu 
            20                  25                  30          


Ser Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu Asp Pro 
        35                  40                  45              


Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe 
    50                  55                  60                  


Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys 
65                  70                  75                  80  


Phe Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu 
                85                  90                  95      


Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys 
            100                 105                 110         


Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val 
        115                 120                 125             


Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro 
    130                 135                 140                 


Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu 
145                 150                 155                 160 


Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys 
                165                 170                 175     


Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro 
            180                 185                 190         


Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro 
        195                 200                 205             


Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Glu Trp Arg Val Asp Arg 
    210                 215                 220                 


Glu Arg Leu Ala 
225             


<210>  9070
<211>  135
<212>  PRT
<213>  Homo Sapiens

<400>  9070

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Ala Leu 
    50                  55                  60                  


His Gln Ala Gln Leu Leu Leu Trp Cys Thr Thr Ala Pro Leu Pro Gly 
65                  70                  75                  80  


Leu Pro Gln Pro Gln Pro Ala Arg Ala Leu His Ser Gln Phe Pro Ala 
                85                  90                  95      


Thr Thr Leu Ile Leu Leu Pro Pro Leu Pro Ala Ile Ala Pro Arg Leu 
            100                 105                 110         


Met Pro Val Ala Leu Thr Ile Ala Arg Ser Gln His Arg Leu Leu Pro 
        115                 120                 125             


Arg Ala Ala Glu Arg His Phe 
    130                 135 


<210>  9071
<211>  241
<212>  PRT
<213>  Homo Sapiens

<400>  9071

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Leu 
    50                  55                  60                  


Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe 
65                  70                  75                  80  


Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly 
                85                  90                  95      


Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr 
            100                 105                 110         


Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser 
        115                 120                 125             


Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly 
    130                 135                 140                 


Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala 
145                 150                 155                 160 


Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn 
                165                 170                 175     


Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met 
            180                 185                 190         


Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser 
        195                 200                 205             


Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly 
    210                 215                 220                 


Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn 
225                 230                 235                 240 


Leu 
    


<210>  9072
<211>  159
<212>  PRT
<213>  Homo Sapiens

<400>  9072

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn 
    50                  55                  60                  


Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg 
65                  70                  75                  80  


Asp Ile Ser Glu Met Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly 
                85                  90                  95      


Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu 
            100                 105                 110         


Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr 
        115                 120                 125             


Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser 
    130                 135                 140                 


Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
145                 150                 155                 


<210>  9073
<211>  264
<212>  PRT
<213>  Homo Sapiens

<400>  9073

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn 
    50                  55                  60                  


Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg 
65                  70                  75                  80  


Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu 
                85                  90                  95      


Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu 
            100                 105                 110         


Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr 
        115                 120                 125             


Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr 
    130                 135                 140                 


Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln 
145                 150                 155                 160 


Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val 
                165                 170                 175     


Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val 
            180                 185                 190         


Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala 
        195                 200                 205             


Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His 
    210                 215                 220                 


Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys 
225                 230                 235                 240 


Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala 
                245                 250                 255     


Val Ala Ala Thr Ser Ala Asn Leu 
            260                 


<210>  9074
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  9074

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn 
    50                  55                  60                  


Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg 
65                  70                  75                  80  


Asp Ile Ser Glu Met Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala 
                85                  90                  95      


Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu 
            100                 105                 110         


Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu 
        115                 120                 125             


Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro 
    130                 135                 140                 


Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg 
145                 150                 155                 160 


Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser 
                165                 170                 175     


Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
            180                 185                 


<210>  9075
<211>  80
<212>  PRT
<213>  Homo Sapiens

<400>  9075

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Ile Pro 
    50                  55                  60                  


Ala Pro Thr Thr Thr Lys Ser Cys Arg Glu Thr Phe Leu Lys Cys Glu 
65                  70                  75                  80  


<210>  9076
<211>  239
<212>  PRT
<213>  Homo Sapiens

<400>  9076

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Ile Pro 
    50                  55                  60                  


Ala Pro Thr Thr Thr Lys Ser Cys Arg Glu Thr Phe Leu Lys Trp Pro 
65                  70                  75                  80  


Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile 
                85                  90                  95      


Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala 
            100                 105                 110         


Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val 
        115                 120                 125             


Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly 
    130                 135                 140                 


Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val 
145                 150                 155                 160 


Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly 
                165                 170                 175     


Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu 
            180                 185                 190         


Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr 
        195                 200                 205             


Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser 
    210                 215                 220                 


Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
225                 230                 235                 


<210>  9077
<211>  268
<212>  PRT
<213>  Homo Sapiens

<400>  9077

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Leu Ser 
    50                  55                  60                  


Thr Gly Val Ser Phe Phe Phe Leu Ser Phe His Ile Ser Asn Leu Gln 
65                  70                  75                  80  


Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu 
                85                  90                  95      


Gln Arg Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly 
            100                 105                 110         


Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val 
        115                 120                 125             


Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val 
    130                 135                 140                 


Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn 
145                 150                 155                 160 


Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser 
                165                 170                 175     


Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val 
            180                 185                 190         


Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu 
        195                 200                 205             


Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe 
    210                 215                 220                 


Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His 
225                 230                 235                 240 


Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr 
                245                 250                 255     


Glu Lys Glu Trp Arg Val Asp Arg Glu Arg Leu Ala 
            260                 265             


<210>  9078
<211>  123
<212>  PRT
<213>  Homo Sapiens

<400>  9078

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Leu Ser 
    50                  55                  60                  


Thr Gly Val Ser Phe Phe Phe Leu Ser Phe His Ile Ser Asn Leu Gln 
65                  70                  75                  80  


Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu 
                85                  90                  95      


Gln Arg Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly 
            100                 105                 110         


Phe Leu Gly Leu Ser Asn Ile Lys Phe Ser Glu 
        115                 120             


<210>  9079
<211>  166
<212>  PRT
<213>  Homo Sapiens

<400>  9079

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Ser Gly 
    50                  55                  60                  


Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val 
65                  70                  75                  80  


Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln 
                85                  90                  95      


Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp 
            100                 105                 110         


Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg 
        115                 120                 125             


Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser 
    130                 135                 140                 


Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala 
145                 150                 155                 160 


Ala Thr Ser Ala Asn Leu 
                165     


<210>  9080
<211>  484
<212>  PRT
<213>  Homo Sapiens

<400>  9080

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Val Ser 
    50                  55                  60                  


Met Thr Ser Ser Val Leu Ser Ser His Ser Pro Gly Ser Gly Ser Ser 
65                  70                  75                  80  


Thr Thr Gln Gly Gln Asp Val Thr Leu Ala Pro Ala Thr Glu Pro Ala 
                85                  90                  95      


Ser Gly Ser Ala Ala Thr Trp Gly Gln Asp Val Thr Ser Val Pro Val 
            100                 105                 110         


Thr Arg Pro Ala Leu Gly Ser Thr Thr Pro Pro Ala His Asp Val Thr 
        115                 120                 125             


Ser Ala Pro Asp Asn Lys Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 
    130                 135                 140                 


His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 
145                 150                 155                 160 


Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Asn Arg Pro Ala 
                165                 170                 175     


Leu Gly Ser Thr Ala Pro Pro Val His Asn Val Thr Ser Ala Ser Gly 
            180                 185                 190         


Ser Ala Ser Gly Ser Ala Ser Thr Leu Val His Asn Gly Thr Ser Ala 
        195                 200                 205             


Arg Ala Thr Thr Thr Pro Ala Ser Lys Ser Thr Pro Phe Ser Ile Pro 
    210                 215                 220                 


Ser His His Ser Asp Thr Pro Thr Thr Leu Ala Ser His Ser Thr Lys 
225                 230                 235                 240 


Thr Asp Ala Ser Ser Thr His His Ser Thr Val Pro Pro Leu Thr Ser 
                245                 250                 255     


Ser Asn His Ser Thr Ser Pro Gln Leu Ser Thr Gly Val Ser Phe Phe 
            260                 265                 270         


Phe Leu Ser Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu 
        275                 280                 285             


Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu 
    290                 295                 300                 


Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn 
305                 310                 315                 320 


Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe 
                325                 330                 335     


Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln 
            340                 345                 350         


Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val 
        355                 360                 365             


Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly 
    370                 375                 380                 


Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val 
385                 390                 395                 400 


Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg 
                405                 410                 415     


Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr 
            420                 425                 430         


His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val 
        435                 440                 445             


Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly 
    450                 455                 460                 


Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr 
465                 470                 475                 480 


Ser Ala Asn Leu 
                


<210>  9081
<211>  213
<212>  PRT
<213>  Homo Sapiens

<400>  9081

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys 
            20                  25                  30          


Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys 
        35                  40                  45              


Asn Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His Ser Pro Gly 
    50                  55                  60                  


Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu Ala Pro Ala 
65                  70                  75                  80  


Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln Asp Val Thr 
                85                  90                  95      


Ser Val Pro Val Thr Arg Pro Ala Leu Gly Ser Thr Thr Pro Pro Ala 
            100                 105                 110         


Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu 
        115                 120                 125             


Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys 
    130                 135                 140                 


Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr 
145                 150                 155                 160 


Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr 
                165                 170                 175     


Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala 
            180                 185                 190         


Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala 
        195                 200                 205             


Thr Ser Ala Asn Leu 
    210             


<210>  9082
<211>  126
<212>  PRT
<213>  Homo Sapiens

<400>  9082

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Ala Leu His Gln Ala Gln Leu Leu Leu Trp Cys 
    50                  55                  60                  


Thr Thr Ala Pro Leu Pro Gly Leu Pro Gln Pro Gln Pro Ala Arg Ala 
65                  70                  75                  80  


Leu His Ser Gln Phe Pro Ala Thr Thr Leu Ile Leu Leu Pro Pro Leu 
                85                  90                  95      


Pro Ala Ile Ala Pro Arg Leu Met Pro Val Ala Leu Thr Ile Ala Arg 
            100                 105                 110         


Ser Gln His Arg Leu Leu Pro Arg Ala Ala Glu Arg His Phe 
        115                 120                 125     


<210>  9083
<211>  255
<212>  PRT
<213>  Homo Sapiens

<400>  9083

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp 
    50                  55                  60                  


Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu Gln Ile 
65                  70                  75                  80  


Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro 
                85                  90                  95      


Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile 
            100                 105                 110         


Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala 
        115                 120                 125             


Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val 
    130                 135                 140                 


Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly 
145                 150                 155                 160 


Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val 
                165                 170                 175     


Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly 
            180                 185                 190         


Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu 
        195                 200                 205             


Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr 
    210                 215                 220                 


Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser 
225                 230                 235                 240 


Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
                245                 250                 255 


<210>  9084
<211>  96
<212>  PRT
<213>  Homo Sapiens

<400>  9084

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp 
    50                  55                  60                  


Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu Gln Ile 
65                  70                  75                  80  


Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe Ser Glu 
                85                  90                  95      


<210>  9085
<211>  149
<212>  PRT
<213>  Homo Sapiens

<400>  9085

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp 
    50                  55                  60                  


Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu Gln Ile 
65                  70                  75                  80  


Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe Ser Leu 
                85                  90                  95      


Gly Leu Gly Cys Gln Ala Gly Ala Ser Arg Cys Trp Cys Trp Ser Val 
            100                 105                 110         


Phe Trp Leu Arg Trp Pro Leu Ser Ile Ser Leu Pro Trp Leu Ser Val 
        115                 120                 125             


Ser Ala Ala Glu Arg Thr Thr Gly Ser Trp Thr Ser Phe Gln Pro Gly 
    130                 135                 140                 


Ile Pro Thr Ile Leu 
145                 


<210>  9086
<211>  203
<212>  PRT
<213>  Homo Sapiens

<400>  9086

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Ile Pro Ala Pro Thr Thr Thr Lys Ser Cys Arg 
    50                  55                  60                  


Glu Thr Phe Leu Lys Cys Phe Cys Arg Phe Ile Asn Lys Gly Val Phe 
65                  70                  75                  80  


Trp Ala Ser Pro Ile Leu Ser Ser Val Ser Asp Val Pro Phe Pro Phe 
                85                  90                  95      


Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu 
            100                 105                 110         


Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala 
        115                 120                 125             


Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile 
    130                 135                 140                 


Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr 
145                 150                 155                 160 


His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro 
                165                 170                 175     


Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr 
            180                 185                 190         


Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
        195                 200             


<210>  9087
<211>  230
<212>  PRT
<213>  Homo Sapiens

<400>  9087

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Ile Pro Ala Pro Thr Thr Thr Lys Ser Cys Arg 
    50                  55                  60                  


Glu Thr Phe Leu Lys Trp Pro Gly Ser Val Val Val Gln Leu Thr Leu 
65                  70                  75                  80  


Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe 
                85                  90                  95      


Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser 
            100                 105                 110         


Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly 
        115                 120                 125             


Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val 
    130                 135                 140                 


Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln 
145                 150                 155                 160 


Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp 
                165                 170                 175     


Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg 
            180                 185                 190         


Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser 
        195                 200                 205             


Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala 
    210                 215                 220                 


Ala Thr Ser Ala Asn Leu 
225                 230 


<210>  9088
<211>  229
<212>  PRT
<213>  Homo Sapiens

<400>  9088

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser 
    50                  55                  60                  


Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala 
65                  70                  75                  80  


Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn 
                85                  90                  95      


Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp 
            100                 105                 110         


Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala 
        115                 120                 125             


Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu 
    130                 135                 140                 


Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys 
145                 150                 155                 160 


Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr 
                165                 170                 175     


Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr 
            180                 185                 190         


Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala 
        195                 200                 205             


Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala 
    210                 215                 220                 


Thr Ser Ala Asn Leu 
225                 


<210>  9089
<211>  168
<212>  PRT
<213>  Homo Sapiens

<400>  9089

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Leu Ser Thr Gly Val Ser Phe Phe Phe Leu Ser 
    50                  55                  60                  


Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser 
65                  70                  75                  80  


Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Ala Val 
                85                  90                  95      


Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala 
            100                 105                 110         


Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His 
        115                 120                 125             


Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys 
    130                 135                 140                 


Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala 
145                 150                 155                 160 


Val Ala Ala Thr Ser Ala Asn Leu 
                165             


<210>  9090
<211>  198
<212>  PRT
<213>  Homo Sapiens

<400>  9090

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Leu Ser Thr Gly Val Ser Phe Phe Phe Leu Ser 
    50                  55                  60                  


Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser 
65                  70                  75                  80  


Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu 
                85                  90                  95      


Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe 
            100                 105                 110         


Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly 
        115                 120                 125             


Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr 
    130                 135                 140                 


Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Gly Cys 
145                 150                 155                 160 


Leu Ser Val Pro Pro Lys Glu Leu Arg Ala Ala Gly His Leu Ser Ser 
                165                 170                 175     


Pro Gly Tyr Leu Pro Ser Tyr Glu Arg Val Pro His Leu Pro His Pro 
            180                 185                 190         


Trp Ala Leu Cys Ala Pro 
        195             


<210>  9091
<211>  273
<212>  PRT
<213>  Homo Sapiens

<400>  9091

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Leu Ser Thr Gly Val Ser Phe Phe Phe Leu Ser 
    50                  55                  60                  


Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser 
65                  70                  75                  80  


Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu 
                85                  90                  95      


Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe 
            100                 105                 110         


Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly 
        115                 120                 125             


Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr 
    130                 135                 140                 


Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser 
145                 150                 155                 160 


Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly 
                165                 170                 175     


Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala 
            180                 185                 190         


Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn 
        195                 200                 205             


Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met 
    210                 215                 220                 


Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser 
225                 230                 235                 240 


Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly 
                245                 250                 255     


Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn 
            260                 265                 270         


Leu 
    


<210>  9092
<211>  475
<212>  PRT
<213>  Homo Sapiens

<400>  9092

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His 
    50                  55                  60                  


Ser Pro Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu 
65                  70                  75                  80  


Ala Pro Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln 
                85                  90                  95      


Asp Val Thr Ser Val Pro Val Thr Arg Pro Ala Leu Gly Ser Thr Thr 
            100                 105                 110         


Pro Pro Ala His Asp Val Thr Ser Ala Pro Asp Asn Lys Pro Ala Pro 
        115                 120                 125             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    130                 135                 140                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
145                 150                 155                 160 


Ala Pro Asp Asn Arg Pro Ala Leu Gly Ser Thr Ala Pro Pro Val His 
                165                 170                 175     


Asn Val Thr Ser Ala Ser Gly Ser Ala Ser Gly Ser Ala Ser Thr Leu 
            180                 185                 190         


Val His Asn Gly Thr Ser Ala Arg Ala Thr Thr Thr Pro Ala Ser Lys 
        195                 200                 205             


Ser Thr Pro Phe Ser Ile Pro Ser His His Ser Asp Thr Pro Thr Thr 
    210                 215                 220                 


Leu Ala Ser His Ser Thr Lys Thr Asp Ala Ser Ser Thr His His Ser 
225                 230                 235                 240 


Thr Val Pro Pro Leu Thr Ser Ser Asn His Ser Thr Ser Pro Gln Leu 
                245                 250                 255     


Ser Thr Gly Val Ser Phe Phe Phe Leu Ser Phe His Ile Ser Asn Leu 
            260                 265                 270         


Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu 
        275                 280                 285             


Leu Gln Arg Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly 
    290                 295                 300                 


Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val 
305                 310                 315                 320 


Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp 
                325                 330                 335     


Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr 
            340                 345                 350         


Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe 
        355                 360                 365             


Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu 
    370                 375                 380                 


Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala 
385                 390                 395                 400 


Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile 
                405                 410                 415     


Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr 
            420                 425                 430         


His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro 
        435                 440                 445             


Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr 
    450                 455                 460                 


Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
465                 470                 475 


<210>  9093
<211>  1262
<212>  PRT
<213>  Homo Sapiens

<400>  9093

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His 
    50                  55                  60                  


Ser Pro Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu 
65                  70                  75                  80  


Ala Pro Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln 
                85                  90                  95      


Asp Val Thr Ser Val Pro Val Thr Arg Pro Ala Leu Gly Ser Thr Thr 
            100                 105                 110         


Pro Pro Ala His Asp Val Thr Ser Ala Pro Asp Asn Lys Pro Ala Pro 
        115                 120                 125             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    130                 135                 140                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Gln Ala His Gly Val Thr Ser 
145                 150                 155                 160 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                165                 170                 175     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            180                 185                 190         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Ser Ala Pro 
        195                 200                 205             


Gly Ser Thr Ala Pro Ala Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    210                 215                 220                 


Arg Ser Val Pro Gly Ser Thr Ala Pro Gln Ala His Gly Val Thr Ser 
225                 230                 235                 240 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                245                 250                 255     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Val Pro Gly Ser Thr Ala 
            260                 265                 270         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        275                 280                 285             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    290                 295                 300                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Gln Ala His Gly Val Thr Ser 
305                 310                 315                 320 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                325                 330                 335     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            340                 345                 350         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        355                 360                 365             


Gly Ser Thr Ala Pro Ala Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    370                 375                 380                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Gln Ala His Gly Val Thr Ser 
385                 390                 395                 400 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                405                 410                 415     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            420                 425                 430         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        435                 440                 445             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    450                 455                 460                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Ala Ala His Gly Val Thr Ser 
465                 470                 475                 480 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Gln Ala His 
                485                 490                 495     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            500                 505                 510         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        515                 520                 525             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    530                 535                 540                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Thr His Gly Val Thr Ser 
545                 550                 555                 560 


Ala Pro Asp Thr Ser Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                565                 570                 575     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Tyr Thr Ala 
            580                 585                 590         


Pro Ala Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        595                 600                 605             


Gly Ser Thr Ala Pro Gln Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    610                 615                 620                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
625                 630                 635                 640 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                645                 650                 655     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            660                 665                 670         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Glu Ser Arg Pro Ala Pro 
        675                 680                 685             


Gly Ser Thr Ala Arg Ala Ala His Gly Val Thr Ser Ala Pro Glu Ser 
    690                 695                 700                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
705                 710                 715                 720 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                725                 730                 735     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            740                 745                 750         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        755                 760                 765             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    770                 775                 780                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
785                 790                 795                 800 


Ala Pro Asp Thr Arg Pro Ser Pro Pro Gly Ser Thr Ala Pro Pro Ala 
                805                 810                 815     


His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 
            820                 825                 830         


Ala Pro Pro Val His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala 
        835                 840                 845             


Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp 
    850                 855                 860                 


Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr 
865                 870                 875                 880 


Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 
                885                 890                 895     


His Gly Val Thr Ser Ala Pro Asp Thr Arg Arg Ala Pro Gly Ser Thr 
            900                 905                 910         


Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala 
        915                 920                 925             


Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly 
    930                 935                 940                 


Val Thr Ser Ala Pro Asp Asn Arg Pro Ala Leu Gly Ser Thr Ala Pro 
945                 950                 955                 960 


Pro Val His Asn Val Thr Ser Ala Ser Gly Ser Ala Ser Gly Ser Ala 
                965                 970                 975     


Ser Thr Leu Val His Asn Gly Thr Ser Ala Arg Ala Thr Thr Thr Pro 
            980                 985                 990         


Ala Ser Lys Ser Thr Pro Phe Ser  Ile Pro Ser His His  Ser Asp Thr 
        995                 1000                 1005             


Pro Thr  Thr Leu Ala Ser His  Ser Thr Lys Thr Asp  Ala Ser Ser 
    1010                 1015                 1020             


Thr His  His Ser Thr Val Pro  Pro Leu Thr Ser Ser  Asn His Ser 
    1025                 1030                 1035             


Thr Ser  Pro Gln Leu Ser Thr  Gly Val Ser Phe Phe  Phe Leu Ser 
    1040                 1045                 1050             


Phe His  Ile Ser Asn Leu Gln  Phe Asn Ser Ser Leu  Glu Asp Pro 
    1055                 1060                 1065             


Ser Thr  Asp Tyr Tyr Gln Glu  Leu Gln Arg Asp Ile  Ser Glu Met 
    1070                 1075                 1080             


Phe Leu  Gln Ile Tyr Lys Gln  Gly Gly Phe Leu Gly  Leu Ser Asn 
    1085                 1090                 1095             


Ile Lys  Phe Arg Pro Gly Ser  Val Val Val Gln Leu  Thr Leu Ala 
    1100                 1105                 1110             


Phe Arg  Glu Gly Thr Ile Asn  Val His Asp Val Glu  Thr Gln Phe 
    1115                 1120                 1125             


Asn Gln  Tyr Lys Thr Glu Ala  Ala Ser Arg Tyr Asn  Leu Thr Ile 
    1130                 1135                 1140             


Ser Asp  Val Ser Val Ser Asp  Val Pro Phe Pro Phe  Ser Ala Gln 
    1145                 1150                 1155             


Ser Gly  Ala Gly Val Pro Gly  Trp Gly Ile Ala Leu  Leu Val Leu 
    1160                 1165                 1170             


Val Cys  Val Leu Val Ala Leu  Ala Ile Val Tyr Leu  Ile Ala Leu 
    1175                 1180                 1185             


Ala Val  Cys Gln Cys Arg Arg  Lys Asn Tyr Gly Gln  Leu Asp Ile 
    1190                 1195                 1200             


Phe Pro  Ala Arg Asp Thr Tyr  His Pro Met Ser Glu  Tyr Pro Thr 
    1205                 1210                 1215             


Tyr His  Thr His Gly Arg Tyr  Val Pro Pro Ser Ser  Thr Asp Arg 
    1220                 1225                 1230             


Ser Pro  Tyr Glu Lys Val Ser  Ala Gly Asn Gly Gly  Ser Ser Leu 
    1235                 1240                 1245             


Ser Tyr  Thr Asn Pro Ala Val  Ala Ala Thr Ser Ala  Asn Leu 
    1250                 1255                 1260         


<210>  9094
<211>  85
<212>  PRT
<213>  Homo Sapiens

<400>  9094

Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val 
1               5                   10                  15      


Trp Gly Trp Gly Ala Arg Leu Gly His Arg Ala Ala Gly Ala Gly Leu 
            20                  25                  30          


Cys Ser Gly Cys Ala Gly His Cys Leu Ser His Cys Leu Gly Cys Leu 
        35                  40                  45              


Ser Val Pro Pro Lys Glu Leu Arg Ala Ala Gly His Leu Ser Ser Pro 
    50                  55                  60                  


Gly Tyr Leu Pro Ser Tyr Glu Arg Val Pro His Leu Pro His Pro Trp 
65                  70                  75                  80  


Ala Leu Cys Ala Pro 
                85  


<210>  9095
<211>  512
<212>  PRT
<213>  Homo Sapiens

<400>  9095

Met Lys Ala Ile Ile His Leu Thr Leu Leu Ala Leu Leu Ser Val Asn 
1               5                   10                  15      


Thr Ala Thr Asn Gln Gly Asn Ser Ala Asp Ala Val Thr Thr Thr Glu 
            20                  25                  30          


Thr Ala Thr Ser Gly Pro Thr Val Ala Ala Ala Asp Thr Thr Glu Thr 
        35                  40                  45              


Asn Phe Pro Glu Thr Ala Ser Thr Thr Ala Asn Thr Pro Ser Phe Pro 
    50                  55                  60                  


Thr Ala Thr Ser Pro Ala Pro Pro Ile Ile Ser Thr His Ser Ser Ser 
65                  70                  75                  80  


Thr Ile Pro Thr Pro Ala Pro Pro Ile Ile Ser Thr His Ser Ser Ser 
                85                  90                  95      


Thr Ile Pro Ile Pro Thr Ala Ala Asp Ser Glu Ser Thr Thr Asn Val 
            100                 105                 110         


Asn Ser Leu Ala Thr Ser Asp Ile Ile Thr Ala Ser Ser Pro Asn Asp 
        115                 120                 125             


Gly Leu Ile Thr Met Val Pro Ser Glu Thr Gln Ser Asn Asn Glu Met 
    130                 135                 140                 


Ser Pro Thr Thr Glu Asp Asn Gln Ser Ser Gly Pro Pro Thr Gly Thr 
145                 150                 155                 160 


Ala Leu Leu Glu Thr Ser Thr Leu Asn Ser Thr Gly Pro Ser Asn Pro 
                165                 170                 175     


Cys Gln Asp Asp Pro Cys Ala Asp Asn Ser Leu Cys Val Lys Leu His 
            180                 185                 190         


Asn Thr Ser Phe Cys Leu Cys Leu Glu Gly Tyr Tyr Tyr Asn Ser Ser 
        195                 200                 205             


Thr Cys Lys Lys Gly Lys Val Phe Pro Gly Lys Ile Ser Val Thr Val 
    210                 215                 220                 


Ser Glu Thr Phe Asp Pro Glu Glu Lys His Ser Met Ala Tyr Gln Asp 
225                 230                 235                 240 


Leu His Ser Glu Ile Thr Ser Leu Phe Lys Asp Val Phe Gly Thr Ser 
                245                 250                 255     


Val Tyr Gly Gln Thr Val Ile Leu Thr Val Ser Thr Ser Leu Ser Pro 
            260                 265                 270         


Arg Ser Glu Met Arg Ala Asp Asp Lys Phe Val Asn Val Thr Ile Val 
        275                 280                 285             


Thr Ile Leu Ala Glu Thr Thr Ser Asp Asn Glu Lys Thr Val Thr Glu 
    290                 295                 300                 


Lys Ile Asn Lys Ala Ile Arg Ser Ser Ser Ser Asn Phe Leu Asn Tyr 
305                 310                 315                 320 


Asp Leu Thr Leu Arg Cys Asp Tyr Tyr Gly Cys Asn Gln Thr Ala Asp 
                325                 330                 335     


Asp Cys Leu Asn Gly Leu Ala Cys Asp Cys Lys Ser Asp Leu Gln Arg 
            340                 345                 350         


Pro Asn Pro Gln Ser Pro Phe Cys Val Ala Ser Ser Leu Lys Cys Pro 
        355                 360                 365             


Asp Ala Cys Asn Ala Gln His Lys Gln Cys Leu Ile Lys Lys Ser Gly 
    370                 375                 380                 


Gly Ala Pro Glu Cys Ala Cys Val Pro Gly Tyr Gln Glu Asp Ala Asn 
385                 390                 395                 400 


Gly Asn Cys Gln Lys Cys Ala Phe Gly Tyr Ser Gly Leu Asp Cys Lys 
                405                 410                 415     


Asp Lys Phe Gln Leu Ile Leu Thr Ile Val Gly Thr Ile Ala Gly Ile 
            420                 425                 430         


Val Ile Leu Ser Met Ile Ile Ala Leu Ile Val Thr Ala Arg Ser Asn 
        435                 440                 445             


Asn Lys Thr Lys His Ile Glu Glu Glu Asn Leu Ile Asp Glu Asp Phe 
    450                 455                 460                 


Gln Asn Leu Lys Leu Arg Ser Thr Gly Phe Thr Asn Leu Gly Ala Glu 
465                 470                 475                 480 


Gly Ser Val Phe Pro Lys Val Arg Ile Thr Ala Ser Arg Asp Ser Gln 
                485                 490                 495     


Met Gln Asn Pro Tyr Ser Arg His Ser Ser Met Pro Arg Pro Asp Tyr 
            500                 505                 510         


<210>  9096
<211>  184
<212>  PRT
<213>  Homo Sapiens

<400>  9096

Met Lys Ala Ile Ile His Leu Thr Leu Leu Ala Leu Leu Ser Val Asn 
1               5                   10                  15      


Thr Glu Asp Asn Gln Ser Ser Gly Pro Pro Thr Gly Thr Ala Leu Leu 
            20                  25                  30          


Glu Thr Ser Thr Leu Asn Ser Thr Gly Pro Ser Asn Pro Cys Gln Asp 
        35                  40                  45              


Asp Pro Cys Ala Asp Asn Ser Leu Cys Val Lys Leu His Asn Thr Ser 
    50                  55                  60                  


Phe Cys Leu Cys Leu Glu Gly Tyr Tyr Tyr Asn Ser Ser Thr Cys Lys 
65                  70                  75                  80  


Lys Gly Lys Val Phe Pro Gly Lys Ile Ser Val Thr Val Ser Glu Thr 
                85                  90                  95      


Phe Asp Pro Glu Glu Lys His Ser Met Ala Tyr Gln Asp Leu His Ser 
            100                 105                 110         


Glu Ile Thr Ser Leu Phe Lys Asp Val Phe Gly Thr Ser Val Tyr Gly 
        115                 120                 125             


Gln Thr Val Ile Leu Thr Val Ser Thr Ser Leu Ser Pro Arg Ser Glu 
    130                 135                 140                 


Met Arg Ala Asp Asp Lys Phe Val Asn Val Thr Ile Val Thr Ile Leu 
145                 150                 155                 160 


Ala Glu Thr Thr Ser Asp Asn Glu Lys Thr Val Thr Glu Lys Ile Asn 
                165                 170                 175     


Lys Ala Ile Arg Ser Ser Ser Ser 
            180                 


<210>  9097
<211>  709
<212>  PRT
<213>  Homo Sapiens

<400>  9097

Met Gly Cys Leu Trp Gly Leu Ala Leu Pro Leu Phe Phe Phe Cys Trp 
1               5                   10                  15      


Glu Val Gly Val Ser Gly Ser Ser Ala Gly Pro Ser Thr Arg Arg Ala 
            20                  25                  30          


Asp Thr Ala Met Thr Thr Asp Asp Thr Glu Val Pro Ala Met Thr Leu 
        35                  40                  45              


Ala Pro Gly His Ala Ala Leu Glu Thr Gln Thr Leu Ser Ala Glu Thr 
    50                  55                  60                  


Ser Ser Arg Ala Ser Thr Pro Ala Gly Pro Ile Pro Glu Ala Glu Thr 
65                  70                  75                  80  


Arg Gly Ala Lys Arg Ile Ser Pro Ala Arg Glu Thr Arg Ser Phe Thr 
                85                  90                  95      


Lys Thr Ser Pro Asn Phe Met Val Leu Ile Ala Thr Ser Val Glu Thr 
            100                 105                 110         


Ser Ala Ala Ser Gly Ser Pro Glu Gly Ala Gly Met Thr Thr Val Gln 
        115                 120                 125             


Thr Ile Thr Gly Ser Asp Pro Arg Glu Ala Ile Phe Asp Thr Leu Cys 
    130                 135                 140                 


Thr Asp Asp Ser Ser Glu Glu Ala Lys Thr Leu Thr Met Asp Ile Leu 
145                 150                 155                 160 


Thr Leu Ala His Thr Ser Thr Glu Ala Lys Gly Leu Ser Ser Glu Ser 
                165                 170                 175     


Ser Ala Ser Ser Asp Ser Pro His Pro Val Ile Thr Pro Ser Arg Ala 
            180                 185                 190         


Ser Glu Ser Ser Ala Ser Ser Asp Gly Pro His Pro Val Ile Thr Pro 
        195                 200                 205             


Ser Arg Ala Ser Glu Ser Ser Ala Ser Ser Asp Gly Pro His Pro Val 
    210                 215                 220                 


Ile Thr Pro Ser Arg Ala Ser Glu Ser Ser Ala Ser Ser Asp Gly Pro 
225                 230                 235                 240 


His Pro Val Ile Thr Pro Ser Arg Ala Ser Glu Ser Ser Ala Ser Ser 
                245                 250                 255     


Asp Gly Pro His Pro Val Ile Thr Pro Ser Arg Ala Ser Glu Ser Ser 
            260                 265                 270         


Ala Ser Ser Asp Gly Pro His Pro Val Ile Thr Pro Ser Arg Ala Ser 
        275                 280                 285             


Glu Ser Ser Ala Ser Ser Asp Gly Pro His Pro Val Ile Thr Pro Ser 
    290                 295                 300                 


Arg Ala Ser Glu Ser Ser Ala Ser Ser Asp Gly Pro His Pro Val Ile 
305                 310                 315                 320 


Thr Pro Ser Arg Ala Ser Glu Ser Ser Ala Ser Ser Asp Gly Pro His 
                325                 330                 335     


Pro Val Ile Thr Pro Ser Arg Ala Ser Glu Ser Ser Ala Ser Ser Asp 
            340                 345                 350         


Gly Leu His Pro Val Ile Thr Pro Ser Arg Ala Ser Glu Ser Ser Ala 
        355                 360                 365             


Ser Ser Asp Gly Pro His Pro Val Ile Thr Pro Ser Arg Ala Ser Glu 
    370                 375                 380                 


Ser Ser Ala Ser Ser Asp Gly Pro His Pro Val Ile Thr Pro Ser Trp 
385                 390                 395                 400 


Ser Pro Gly Ser Asp Val Thr Leu Leu Ala Glu Ala Leu Val Thr Val 
                405                 410                 415     


Thr Asn Ile Glu Val Ile Asn Cys Ser Ile Thr Glu Ile Glu Thr Thr 
            420                 425                 430         


Thr Ser Ser Ile Pro Gly Ala Ser Asp Thr Asp Leu Ile Pro Thr Glu 
        435                 440                 445             


Gly Val Lys Ala Ser Ser Thr Ser Asp Pro Pro Ala Leu Pro Asp Ser 
    450                 455                 460                 


Thr Glu Ala Lys Pro His Ile Thr Glu Val Thr Ala Ser Ala Glu Thr 
465                 470                 475                 480 


Leu Ser Thr Ala Gly Thr Thr Glu Ser Ala Ala Pro Asp Ala Thr Val 
                485                 490                 495     


Gly Thr Pro Leu Pro Thr Asn Ser Ala Thr Glu Arg Glu Val Thr Ala 
            500                 505                 510         


Pro Gly Ala Thr Thr Leu Ser Gly Ala Leu Val Thr Val Ser Arg Asn 
        515                 520                 525             


Pro Leu Glu Glu Thr Ser Ala Leu Ser Val Glu Thr Pro Ser Tyr Val 
    530                 535                 540                 


Lys Val Ser Gly Ala Ala Pro Val Ser Ile Glu Ala Gly Ser Ala Val 
545                 550                 555                 560 


Gly Lys Thr Thr Ser Phe Ala Gly Ser Ser Ala Ser Ser Tyr Ser Pro 
                565                 570                 575     


Ser Glu Ala Ala Leu Lys Asn Phe Thr Pro Ser Glu Thr Pro Thr Met 
            580                 585                 590         


Asp Ile Ala Thr Lys Gly Pro Phe Pro Thr Ser Arg Asp Pro Leu Pro 
        595                 600                 605             


Ser Val Pro Pro Thr Thr Thr Asn Ser Ser Arg Gly Thr Asn Ser Thr 
    610                 615                 620                 


Leu Ala Lys Ile Thr Thr Ser Ala Lys Thr Thr Met Lys Pro Pro Thr 
625                 630                 635                 640 


Ala Thr Pro Thr Thr Ala Arg Thr Arg Pro Thr Thr Asp Val Ser Ala 
                645                 650                 655     


Gly Glu Asn Gly Gly Phe Leu Leu Leu Arg Leu Ser Val Ala Ser Pro 
            660                 665                 670         


Glu Asp Leu Thr Asp Pro Arg Val Ala Glu Arg Leu Met Gln Gln Leu 
        675                 680                 685             


His Arg Glu Leu His Ala His Ala Pro His Phe Gln Val Ser Leu Leu 
    690                 695                 700                 


Arg Val Arg Arg Gly 
705                 


<210>  9098
<211>  723
<212>  PRT
<213>  Homo Sapiens

<400>  9098

Met Gly Cys Leu Trp Gly Leu Ala Leu Pro Leu Phe Phe Phe Cys Trp 
1               5                   10                  15      


Glu Val Gly Val Ser Gly Ser Ser Ala Gly Pro Ser Thr Arg Arg Ala 
            20                  25                  30          


Asp Thr Ala Met Thr Thr Asp Asp Thr Glu Val Pro Ala Met Thr Leu 
        35                  40                  45              


Ala Pro Gly His Ala Ala Leu Glu Thr Gln Thr Leu Ser Ala Glu Thr 
    50                  55                  60                  


Ser Ser Arg Ala Ser Thr Pro Ala Gly Pro Ile Pro Glu Ala Glu Thr 
65                  70                  75                  80  


Arg Gly Ala Lys Arg Ile Ser Pro Ala Arg Glu Thr Arg Ser Phe Thr 
                85                  90                  95      


Lys Thr Ser Pro Asn Phe Met Val Leu Ile Ala Thr Ser Val Glu Thr 
            100                 105                 110         


Ser Ala Ala Ser Gly Ser Pro Glu Gly Ala Gly Met Thr Thr Val Gln 
        115                 120                 125             


Thr Ile Thr Gly Ser Asp Pro Arg Glu Ala Ile Phe Asp Thr Leu Cys 
    130                 135                 140                 


Thr Asp Asp Ser Ser Glu Glu Ala Lys Thr Leu Thr Met Asp Ile Leu 
145                 150                 155                 160 


Thr Leu Ala His Thr Ser Thr Glu Ala Lys Gly Leu Ser Ser Glu Ser 
                165                 170                 175     


Ser Ala Ser Ser Asp Ser Pro His Pro Val Ile Thr Pro Ser Arg Ala 
            180                 185                 190         


Ser Glu Ser Ser Ala Ser Ser Asp Gly Pro His Pro Val Ile Thr Pro 
        195                 200                 205             


Ser Arg Ala Ser Glu Ser Ser Ala Ser Ser Asp Gly Pro His Pro Val 
    210                 215                 220                 


Ile Thr Pro Ser Arg Ala Ser Glu Ser Ser Ala Ser Ser Asp Gly Pro 
225                 230                 235                 240 


His Pro Val Ile Thr Pro Ser Arg Ala Ser Glu Ser Ser Ala Ser Ser 
                245                 250                 255     


Asp Gly Pro His Pro Val Ile Thr Pro Ser Arg Ala Ser Glu Ser Ser 
            260                 265                 270         


Ala Ser Ser Asp Gly Pro His Pro Val Ile Thr Pro Ser Arg Ala Ser 
        275                 280                 285             


Glu Ser Ser Ala Ser Ser Asp Gly Pro His Pro Val Ile Thr Pro Ser 
    290                 295                 300                 


Arg Ala Ser Glu Ser Ser Ala Ser Ser Asp Gly Pro His Pro Val Ile 
305                 310                 315                 320 


Thr Pro Ser Arg Ala Ser Glu Ser Ser Ala Ser Ser Asp Gly Pro His 
                325                 330                 335     


Pro Val Ile Thr Pro Ser Arg Ala Ser Glu Ser Ser Ala Ser Ser Asp 
            340                 345                 350         


Gly Leu His Pro Val Ile Thr Pro Ser Arg Ala Ser Glu Ser Ser Ala 
        355                 360                 365             


Ser Ser Asp Gly Pro His Pro Val Ile Thr Pro Ser Arg Ala Ser Glu 
    370                 375                 380                 


Ser Ser Ala Ser Ser Asp Gly Pro His Pro Val Ile Thr Pro Ser Trp 
385                 390                 395                 400 


Ser Pro Gly Ser Asp Val Thr Leu Leu Ala Glu Ala Leu Val Thr Val 
                405                 410                 415     


Thr Asn Ile Glu Val Ile Asn Cys Ser Ile Thr Glu Ile Glu Thr Thr 
            420                 425                 430         


Thr Ser Ser Ile Pro Gly Ala Ser Asp Thr Asp Leu Ile Pro Thr Glu 
        435                 440                 445             


Gly Val Lys Ala Ser Ser Thr Ser Asp Pro Pro Ala Leu Pro Asp Ser 
    450                 455                 460                 


Thr Glu Ala Lys Pro His Ile Thr Glu Val Thr Ala Ser Ala Glu Thr 
465                 470                 475                 480 


Leu Ser Thr Ala Gly Thr Thr Glu Ser Ala Ala Pro Asp Ala Thr Val 
                485                 490                 495     


Gly Thr Pro Leu Pro Thr Asn Ser Ala Thr Glu Arg Glu Val Thr Ala 
            500                 505                 510         


Pro Gly Ala Thr Thr Leu Ser Gly Ala Leu Val Thr Val Ser Arg Asn 
        515                 520                 525             


Pro Leu Glu Glu Thr Ser Ala Leu Ser Val Glu Thr Pro Ser Tyr Val 
    530                 535                 540                 


Lys Val Ser Gly Ala Ala Pro Val Ser Ile Glu Ala Gly Ser Ala Val 
545                 550                 555                 560 


Gly Lys Thr Thr Ser Phe Ala Gly Ser Ser Ala Ser Ser Tyr Ser Pro 
                565                 570                 575     


Ser Glu Ala Ala Leu Lys Asn Phe Thr Pro Ser Glu Thr Pro Thr Met 
            580                 585                 590         


Asp Ile Ala Thr Lys Gly Pro Phe Pro Thr Ser Arg Asp Pro Leu Pro 
        595                 600                 605             


Ser Val Pro Pro Thr Thr Thr Asn Ser Ser Arg Gly Thr Asn Ser Thr 
    610                 615                 620                 


Leu Ala Lys Ile Thr Thr Ser Ala Lys Thr Thr Met Lys Pro Pro Thr 
625                 630                 635                 640 


Ala Thr Pro Thr Thr Ala Arg Thr Arg Pro Thr Thr Asp Val Ser Ala 
                645                 650                 655     


Gly Glu Asn Gly Gly Phe Leu Leu Leu Arg Leu Ser Val Ala Ser Pro 
            660                 665                 670         


Glu Asp Leu Thr Asp Pro Arg Val Ala Glu Arg Leu Met Gln Gln Met 
        675                 680                 685             


Glu Arg Ser Leu Ala Leu Ser Pro Arg Leu Glu Cys Ser Gly Val Ile 
    690                 695                 700                 


Ser Ala His Cys Lys Leu His Leu Leu Gly Ser Arg Asp Ser Pro Ala 
705                 710                 715                 720 


Ser Ala Ser 
            


<210>  9099
<211>  538
<212>  PRT
<213>  Homo Sapiens

<400>  9099

Met Gly Cys Leu Trp Gly Leu Ala Leu Pro Leu Phe Phe Phe Cys Trp 
1               5                   10                  15      


Glu Val Gly Val Ser Gly Ser Ser Ala Gly Pro Ser Thr Arg Arg Ala 
            20                  25                  30          


Asp Thr Ala Met Thr Thr Asp Asp Thr Glu Val Pro Ala Met Thr Leu 
        35                  40                  45              


Ala Pro Gly His Ala Ala Leu Glu Thr Gln Thr Leu Ser Ala Glu Thr 
    50                  55                  60                  


Ser Ser Arg Ala Ser Thr Pro Ala Gly Pro Ile Pro Glu Ala Glu Thr 
65                  70                  75                  80  


Arg Gly Ala Lys Arg Ile Ser Pro Ala Arg Glu Thr Arg Ser Phe Thr 
                85                  90                  95      


Lys Thr Ser Pro Asn Phe Met Val Leu Ile Ala Thr Ser Val Glu Thr 
            100                 105                 110         


Ser Ala Ala Ser Gly Ser Pro Glu Gly Ala Gly Met Thr Thr Val Gln 
        115                 120                 125             


Thr Ile Thr Gly Ser Asp Pro Arg Glu Ala Ile Phe Asp Thr Leu Cys 
    130                 135                 140                 


Thr Asp Asp Ser Ser Glu Glu Ala Lys Thr Leu Thr Met Asp Ile Leu 
145                 150                 155                 160 


Thr Leu Ala His Thr Ser Thr Glu Ala Lys Gly Leu Ser Ser Glu Ser 
                165                 170                 175     


Ser Ala Ser Ser Asp Ser Pro His Pro Val Ile Thr Pro Ser Arg Ala 
            180                 185                 190         


Ser Glu Ser Ser Ala Ser Ser Asp Gly Pro His Pro Val Ile Thr Pro 
        195                 200                 205             


Ser Arg Ala Ser Glu Ser Ser Ala Ser Ser Asp Gly Pro His Pro Val 
    210                 215                 220                 


Ile Thr Pro Ser Trp Ser Pro Gly Ser Asp Val Thr Leu Leu Ala Glu 
225                 230                 235                 240 


Ala Leu Val Thr Val Thr Asn Ile Glu Val Ile Asn Cys Ser Ile Thr 
                245                 250                 255     


Glu Ile Glu Thr Thr Thr Ser Ser Ile Pro Gly Ala Ser Asp Thr Asp 
            260                 265                 270         


Leu Ile Pro Thr Glu Gly Val Lys Ala Ser Ser Thr Ser Asp Pro Pro 
        275                 280                 285             


Ala Leu Pro Asp Ser Thr Glu Ala Lys Pro His Ile Thr Glu Val Thr 
    290                 295                 300                 


Ala Ser Ala Glu Thr Leu Ser Thr Ala Gly Thr Thr Glu Ser Ala Ala 
305                 310                 315                 320 


Pro Asp Ala Thr Val Gly Thr Pro Leu Pro Thr Asn Ser Ala Thr Glu 
                325                 330                 335     


Arg Glu Val Thr Ala Pro Gly Ala Thr Thr Leu Ser Gly Ala Leu Val 
            340                 345                 350         


Thr Val Ser Arg Asn Pro Leu Glu Glu Thr Ser Ala Leu Ser Val Glu 
        355                 360                 365             


Thr Pro Ser Tyr Val Lys Val Ser Gly Ala Ala Pro Val Ser Ile Glu 
    370                 375                 380                 


Ala Gly Ser Ala Val Gly Lys Thr Thr Ser Phe Ala Gly Ser Ser Ala 
385                 390                 395                 400 


Ser Ser Tyr Ser Pro Ser Glu Ala Ala Leu Lys Asn Phe Thr Pro Ser 
                405                 410                 415     


Glu Thr Pro Thr Met Asp Ile Ala Thr Lys Gly Pro Phe Pro Thr Ser 
            420                 425                 430         


Arg Asp Pro Leu Pro Ser Val Pro Pro Thr Thr Thr Asn Ser Ser Arg 
        435                 440                 445             


Gly Thr Asn Ser Thr Leu Ala Lys Ile Thr Thr Ser Ala Lys Thr Thr 
    450                 455                 460                 


Met Lys Pro Pro Thr Ala Thr Pro Thr Thr Ala Arg Thr Arg Pro Thr 
465                 470                 475                 480 


Thr Asp Val Ser Ala Gly Glu Asn Gly Gly Phe Leu Leu Leu Arg Leu 
                485                 490                 495     


Ser Val Ala Ser Pro Glu Asp Leu Thr Asp Pro Arg Val Ala Glu Arg 
            500                 505                 510         


Leu Met Gln Gln Leu His Arg Glu Leu His Ala His Ala Pro His Phe 
        515                 520                 525             


Gln Val Ser Leu Leu Arg Val Arg Arg Gly 
    530                 535             


<210>  9100
<211>  674
<212>  PRT
<213>  Homo Sapiens

<400>  9100

Met Thr Thr Asp Asp Thr Glu Val Pro Ala Met Thr Leu Ala Pro Gly 
1               5                   10                  15      


His Ala Ala Leu Glu Thr Gln Thr Leu Ser Ala Glu Thr Ser Ser Arg 
            20                  25                  30          


Ala Ser Thr Pro Ala Gly Pro Ile Pro Glu Ala Glu Thr Arg Gly Ala 
        35                  40                  45              


Lys Arg Ile Ser Pro Ala Arg Glu Thr Arg Ser Phe Thr Lys Thr Ser 
    50                  55                  60                  


Pro Asn Phe Met Val Leu Ile Ala Thr Ser Val Glu Thr Ser Ala Ala 
65                  70                  75                  80  


Ser Gly Ser Pro Glu Gly Ala Gly Met Thr Thr Val Gln Thr Ile Thr 
                85                  90                  95      


Gly Ser Asp Pro Arg Glu Ala Ile Phe Asp Thr Leu Cys Thr Asp Asp 
            100                 105                 110         


Ser Ser Glu Glu Ala Lys Thr Leu Thr Met Asp Ile Leu Thr Leu Ala 
        115                 120                 125             


His Thr Ser Thr Glu Ala Lys Gly Leu Ser Ser Glu Ser Ser Ala Ser 
    130                 135                 140                 


Ser Asp Ser Pro His Pro Val Ile Thr Pro Ser Arg Ala Ser Glu Ser 
145                 150                 155                 160 


Ser Ala Ser Ser Asp Gly Pro His Pro Val Ile Thr Pro Ser Arg Ala 
                165                 170                 175     


Ser Glu Ser Ser Ala Ser Ser Asp Gly Pro His Pro Val Ile Thr Pro 
            180                 185                 190         


Ser Arg Ala Ser Glu Ser Ser Ala Ser Ser Asp Gly Pro His Pro Val 
        195                 200                 205             


Ile Thr Pro Ser Arg Ala Ser Glu Ser Ser Ala Ser Ser Asp Gly Pro 
    210                 215                 220                 


His Pro Val Ile Thr Pro Ser Arg Ala Ser Glu Ser Ser Ala Ser Ser 
225                 230                 235                 240 


Asp Gly Pro His Pro Val Ile Thr Pro Ser Arg Ala Ser Glu Ser Ser 
                245                 250                 255     


Ala Ser Ser Asp Gly Pro His Pro Val Ile Thr Pro Ser Arg Ala Ser 
            260                 265                 270         


Glu Ser Ser Ala Ser Ser Asp Gly Pro His Pro Val Ile Thr Pro Ser 
        275                 280                 285             


Arg Ala Ser Glu Ser Ser Ala Ser Ser Asp Gly Pro His Pro Val Ile 
    290                 295                 300                 


Thr Pro Ser Arg Ala Ser Glu Ser Ser Ala Ser Ser Asp Gly Leu His 
305                 310                 315                 320 


Pro Val Ile Thr Pro Ser Arg Ala Ser Glu Ser Ser Ala Ser Ser Asp 
                325                 330                 335     


Gly Pro His Pro Val Ile Thr Pro Ser Arg Ala Ser Glu Ser Ser Ala 
            340                 345                 350         


Ser Ser Asp Gly Pro His Pro Val Ile Thr Pro Ser Trp Ser Pro Gly 
        355                 360                 365             


Ser Asp Val Thr Leu Leu Ala Glu Ala Leu Val Thr Val Thr Asn Ile 
    370                 375                 380                 


Glu Val Ile Asn Cys Ser Ile Thr Glu Ile Glu Thr Thr Thr Ser Ser 
385                 390                 395                 400 


Ile Pro Gly Ala Ser Asp Thr Asp Leu Ile Pro Thr Glu Gly Val Lys 
                405                 410                 415     


Ala Ser Ser Thr Ser Asp Pro Pro Ala Leu Pro Asp Ser Thr Glu Ala 
            420                 425                 430         


Lys Pro His Ile Thr Glu Val Thr Ala Ser Ala Glu Thr Leu Ser Thr 
        435                 440                 445             


Ala Gly Thr Thr Glu Ser Ala Ala Pro Asp Ala Thr Val Gly Thr Pro 
    450                 455                 460                 


Leu Pro Thr Asn Ser Ala Thr Glu Arg Glu Val Thr Ala Pro Gly Ala 
465                 470                 475                 480 


Thr Thr Leu Ser Gly Ala Leu Val Thr Val Ser Arg Asn Pro Leu Glu 
                485                 490                 495     


Glu Thr Ser Ala Leu Ser Val Glu Thr Pro Ser Tyr Val Lys Val Ser 
            500                 505                 510         


Gly Ala Ala Pro Val Ser Ile Glu Ala Gly Ser Ala Val Gly Lys Thr 
        515                 520                 525             


Thr Ser Phe Ala Gly Ser Ser Ala Ser Ser Tyr Ser Pro Ser Glu Ala 
    530                 535                 540                 


Ala Leu Lys Asn Phe Thr Pro Ser Glu Thr Pro Thr Met Asp Ile Ala 
545                 550                 555                 560 


Thr Lys Gly Pro Phe Pro Thr Ser Arg Asp Pro Leu Pro Ser Val Pro 
                565                 570                 575     


Pro Thr Thr Thr Asn Ser Ser Arg Gly Thr Asn Ser Thr Leu Ala Lys 
            580                 585                 590         


Ile Thr Thr Ser Ala Lys Thr Thr Met Lys Pro Pro Thr Ala Thr Pro 
        595                 600                 605             


Thr Thr Ala Arg Thr Arg Pro Thr Thr Asp Val Ser Ala Gly Glu Asn 
    610                 615                 620                 


Gly Gly Phe Leu Leu Leu Arg Leu Ser Val Ala Ser Pro Glu Asp Leu 
625                 630                 635                 640 


Thr Asp Pro Arg Val Ala Glu Arg Leu Met Gln Gln Leu His Arg Glu 
                645                 650                 655     


Leu His Ala His Ala Pro His Phe Gln Val Ser Leu Leu Arg Val Arg 
            660                 665                 670         


Arg Gly 
        


<210>  9101
<211>  128
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9101

Xaa Pro Thr Met Asp Ile Ala Thr Lys Gly Pro Phe Pro Thr Ser Arg 
1               5                   10                  15      


Asp Pro Leu Pro Ser Val Pro Pro Thr Thr Thr Asn Ser Ser Arg Gly 
            20                  25                  30          


Thr Asn Ser Thr Leu Ala Lys Ile Thr Thr Ser Ala Lys Thr Thr Met 
        35                  40                  45              


Lys Pro Pro Thr Ala Thr Pro Thr Thr Ala Arg Thr Arg Pro Thr Thr 
    50                  55                  60                  


Asp Val Ser Ala Gly Glu Asn Gly Gly Phe Leu Leu Leu Arg Leu Ser 
65                  70                  75                  80  


Val Ala Ser Pro Glu Asp Leu Thr Asp Pro Arg Val Ala Glu Arg Leu 
                85                  90                  95      


Met Gln Gln Leu Met Thr Gln Gly Thr His Ser Ala His Val Pro Ser 
            100                 105                 110         


Met Val Gly Val Asn Pro Leu Pro Ile Val Pro Gly Gly Phe Gln His 
        115                 120                 125             


<210>  9102
<211>  3323
<212>  PRT
<213>  Homo Sapiens

<400>  9102

Met Gln Leu Leu Gly Leu Leu Gly Leu Leu Trp Met Leu Lys Ala Ser 
1               5                   10                  15      


Pro Trp Ala Thr Gly Thr Leu Ser Thr Ala Thr Ser Ile Ser Gln Val 
            20                  25                  30          


Pro Phe Pro Arg Ala Glu Ala Ala Ser Ala Val Leu Ser Asn Ser Pro 
        35                  40                  45              


His Ser Arg Asp Leu Ala Gly Trp Pro Leu Gly Val Pro Gln Leu Ala 
    50                  55                  60                  


Ser Pro Ala Pro Gly His Arg Glu Asn Ala Pro Met Thr Leu Thr Thr 
65                  70                  75                  80  


Ser Pro His Asp Thr Leu Ile Ser Glu Thr Leu Leu Asn Ser Pro Val 
                85                  90                  95      


Ser Ser Asn Thr Ser Thr Thr Pro Thr Ser Lys Phe Ala Phe Lys Val 
            100                 105                 110         


Glu Thr Thr Pro Pro Thr Val Leu Val Tyr Ser Ala Thr Thr Glu Cys 
        115                 120                 125             


Val Tyr Pro Thr Ser Phe Ile Ile Thr Ile Ser His Pro Thr Ser Ile 
    130                 135                 140                 


Cys Val Thr Thr Thr Gln Val Ala Phe Thr Ser Ser Tyr Thr Ser Thr 
145                 150                 155                 160 


Pro Val Thr Gln Lys Pro Val Thr Thr Val Thr Ser Thr Tyr Ser Met 
                165                 170                 175     


Thr Thr Thr Glu Lys Gly Thr Ser Ala Met Thr Ser Ser Pro Ser Thr 
            180                 185                 190         


Thr Thr Ala Arg Glu Thr Pro Ile Val Thr Val Thr Pro Ser Ser Val 
        195                 200                 205             


Ser Ala Thr Asp Thr Thr Phe His Thr Thr Ile Ser Ser Thr Thr Arg 
    210                 215                 220                 


Thr Thr Glu Arg Thr Pro Leu Pro Thr Gly Ser Ile His Thr Thr Thr 
225                 230                 235                 240 


Ser Pro Thr Pro Val Phe Thr Thr Leu Lys Thr Ala Val Thr Ser Thr 
                245                 250                 255     


Ser Pro Ile Thr Ser Ser Ile Thr Ser Thr Asn Thr Val Thr Ser Met 
            260                 265                 270         


Thr Thr Thr Ala Ser Gln Pro Thr Ala Thr Asn Thr Leu Ser Ser Pro 
        275                 280                 285             


Thr Arg Thr Ile Leu Ser Ser Thr Pro Val Leu Ser Thr Glu Thr Ile 
    290                 295                 300                 


Thr Ser Gly Ile Thr Asn Thr Thr Pro Leu Ser Thr Leu Val Thr Thr 
305                 310                 315                 320 


Leu Pro Thr Thr Ile Ser Arg Ser Thr Pro Thr Ser Glu Thr Thr Tyr 
                325                 330                 335     


Thr Thr Ser Pro Thr Ser Thr Val Thr Asp Ser Thr Thr Lys Ile Ala 
            340                 345                 350         


Tyr Ser Thr Ser Met Thr Gly Thr Leu Ser Thr Glu Thr Ser Leu Pro 
        355                 360                 365             


Pro Thr Ser Ser Ser Leu Pro Thr Thr Glu Thr Ala Thr Thr Pro Met 
    370                 375                 380                 


Thr Asn Leu Val Thr Thr Thr Thr Glu Ile Ser Ser His Ser Thr Pro 
385                 390                 395                 400 


Ser Phe Ser Ser Ser Thr Ile Tyr Ser Thr Val Ser Thr Ser Thr Thr 
                405                 410                 415     


Ala Ile Ser Ser Leu Pro Pro Thr Ser Gly Thr Met Val Thr Ser Thr 
            420                 425                 430         


Thr Met Thr Pro Ser Ser Leu Ser Thr Asp Ile Pro Phe Thr Thr Pro 
        435                 440                 445             


Thr Thr Ile Thr His His Ser Val Gly Ser Thr Gly Phe Leu Thr Thr 
    450                 455                 460                 


Ala Thr Asp Leu Thr Ser Thr Phe Thr Val Ser Ser Ser Ser Ala Met 
465                 470                 475                 480 


Ser Thr Ser Val Ile Pro Ser Ser Pro Ser Ile Gln Asn Thr Glu Thr 
                485                 490                 495     


Ser Ser Leu Val Ser Met Thr Ser Ala Thr Thr Pro Asn Val Arg Pro 
            500                 505                 510         


Thr Phe Val Ser Thr Leu Ser Thr Pro Thr Ser Ser Leu Leu Thr Thr 
        515                 520                 525             


Phe Pro Ala Thr Tyr Ser Phe Ser Ser Ser Met Ser Ala Ser Ser Ala 
    530                 535                 540                 


Gly Thr Thr His Thr Glu Ser Ile Ser Ser Pro Pro Ala Ser Thr Ser 
545                 550                 555                 560 


Thr Leu His Thr Thr Ala Glu Ser Thr Leu Ala Pro Thr Thr Thr Thr 
                565                 570                 575     


Ser Phe Thr Thr Ser Thr Thr Met Glu Pro Pro Ser Thr Thr Ala Ala 
            580                 585                 590         


Thr Thr Gly Thr Gly Gln Thr Thr Phe Thr Ser Ser Thr Ala Thr Phe 
        595                 600                 605             


Pro Glu Thr Thr Thr Pro Thr Pro Thr Thr Asp Met Ser Thr Glu Ser 
    610                 615                 620                 


Leu Thr Thr Ala Met Thr Ser Pro Pro Ile Thr Ser Ser Val Thr Ser 
625                 630                 635                 640 


Thr Asn Thr Val Thr Ser Met Thr Thr Thr Thr Ser Pro Pro Thr Thr 
                645                 650                 655     


Thr Asn Ser Phe Thr Ser Leu Thr Ser Met Pro Leu Ser Ser Thr Pro 
            660                 665                 670         


Val Pro Ser Thr Glu Val Val Thr Ser Gly Thr Ile Asn Thr Ile Pro 
        675                 680                 685             


Pro Ser Ile Leu Val Thr Thr Leu Pro Thr Pro Asn Ala Ser Ser Met 
    690                 695                 700                 


Thr Thr Ser Glu Thr Thr Tyr Pro Asn Ser Pro Thr Gly Pro Gly Thr 
705                 710                 715                 720 


Asn Ser Thr Thr Glu Ile Thr Tyr Pro Thr Thr Met Thr Glu Thr Ser 
                725                 730                 735     


Ser Thr Ala Thr Ser Leu Pro Pro Thr Ser Pro Leu Val Ser Thr Ala 
            740                 745                 750         


Lys Thr Ala Lys Thr Pro Thr Thr Asn Leu Val Thr Thr Thr Thr Lys 
        755                 760                 765             


Thr Thr Ser His Ser Thr Thr Ser Phe Thr Ser Ser Thr Val Tyr Ser 
    770                 775                 780                 


Thr Ala Ser Thr Tyr Thr Thr Ala Ile Thr Ser Val Pro Thr Thr Leu 
785                 790                 795                 800 


Gly Thr Met Val Thr Ser Thr Ser Met Ile Ser Ser Thr Val Ser Thr 
                805                 810                 815     


Gly Ile Pro Thr Ser Gln Pro Thr Thr Ile Thr Pro Ser Ser Val Gly 
            820                 825                 830         


Ile Ser Gly Ser Leu Pro Met Met Thr Asp Leu Thr Ser Val Tyr Thr 
        835                 840                 845             


Val Ser Asn Met Ser Ala Arg Pro Thr Thr Val Ile Pro Ser Ser Pro 
    850                 855                 860                 


Thr Val Gln Asn Thr Glu Ile Ser Ile Ser Val Ser Met Thr Ser Ala 
865                 870                 875                 880 


Thr Thr Pro Ser Gly Gly Pro Thr Phe Thr Ser Thr Glu Asn Thr Pro 
                885                 890                 895     


Thr Arg Ser Leu Leu Thr Ser Phe Pro Met Thr His Ser Phe Ser Ser 
            900                 905                 910         


Ser Met Ser Glu Ser Ser Ala Gly Thr Thr His Thr Glu Ser Ile Ser 
        915                 920                 925             


Ser Pro Arg Gly Thr Thr Ser Thr Leu His Thr Thr Val Glu Ser Thr 
    930                 935                 940                 


Pro Ser Pro Thr Thr Thr Thr Ser Phe Thr Thr Ser Thr Met Met Glu 
945                 950                 955                 960 


Pro Pro Ser Ser Thr Val Ser Thr Thr Gly Arg Gly Gln Thr Thr Phe 
                965                 970                 975     


Pro Ser Ser Thr Ala Thr Phe Pro Glu Thr Thr Thr Leu Thr Pro Thr 
            980                 985                 990         


Thr Asp Ile Ser Thr Val Ser Leu  Thr Thr Ala Met Thr  Ser Pro Pro 
        995                 1000                 1005             


Pro Val  Ser Ser Ser Ile Thr  Pro Thr Asn Thr Met  Thr Ser Met 
    1010                 1015                 1020             


Arg Thr  Thr Thr Tyr Trp Pro  Thr Ala Thr Asn Thr  Leu Ser Pro 
    1025                 1030                 1035             


Leu Thr  Ser Ser Ile Leu Ser  Ser Thr Pro Val Pro  Ser Thr Glu 
    1040                 1045                 1050             


Met Ile  Thr Ser His Thr Thr  Asn Thr Thr Pro Leu  Ser Thr Leu 
    1055                 1060                 1065             


Val Thr  Thr Leu Leu Thr Thr  Ile Thr Arg Ser Thr  Pro Thr Ser 
    1070                 1075                 1080             


Glu Thr  Thr Tyr Pro Thr Ser  Pro Thr Ser Ile Val  Ser Asp Ser 
    1085                 1090                 1095             


Thr Thr  Glu Ile Thr Tyr Ser  Thr Ser Ile Thr Gly  Thr Leu Ser 
    1100                 1105                 1110             


Thr Ala  Thr Thr Leu Pro Pro  Thr Ser Ser Ser Leu  Pro Thr Thr 
    1115                 1120                 1125             


Glu Thr  Ala Thr Met Thr Pro  Thr Thr Thr Leu Ile  Thr Thr Thr 
    1130                 1135                 1140             


Pro Asn  Thr Thr Ser Leu Ser  Thr Pro Ser Phe Thr  Ser Ser Thr 
    1145                 1150                 1155             


Ile Tyr  Ser Thr Val Ser Thr  Ser Thr Thr Ala Ile  Ser Ser Ala 
    1160                 1165                 1170             


Ser Pro  Thr Ser Gly Thr Met  Val Thr Ser Thr Thr  Met Thr Pro 
    1175                 1180                 1185             


Ser Ser  Leu Ser Thr Asp Thr  Pro Ser Thr Thr Pro  Thr Thr Ile 
    1190                 1195                 1200             


Thr Tyr  Pro Ser Val Gly Ser  Thr Gly Phe Leu Thr  Thr Ala Thr 
    1205                 1210                 1215             


Asp Leu  Thr Ser Thr Phe Thr  Val Ser Ser Ser Ser  Ala Met Ser 
    1220                 1225                 1230             


Thr Ser  Val Ile Pro Ser Ser  Pro Ser Ile Gln Asn  Thr Glu Thr 
    1235                 1240                 1245             


Ser Ser  Leu Val Ser Met Thr  Ser Ala Thr Thr Pro  Ser Leu Arg 
    1250                 1255                 1260             


Pro Thr  Ile Thr Ser Thr Asp  Ser Thr Leu Thr Ser  Ser Leu Leu 
    1265                 1270                 1275             


Thr Thr  Phe Pro Ser Thr Tyr  Ser Phe Ser Ser Ser  Met Ser Ala 
    1280                 1285                 1290             


Ser Ser  Ala Gly Thr Thr His  Thr Glu Thr Ile Ser  Ser Leu Pro 
    1295                 1300                 1305             


Ala Ser  Thr Asn Thr Ile His  Thr Thr Ala Glu Ser  Ala Leu Ala 
    1310                 1315                 1320             


Pro Thr  Thr Thr Thr Ser Phe  Thr Thr Ser Pro Thr  Met Glu Pro 
    1325                 1330                 1335             


Pro Ser  Thr Thr Val Ala Thr  Thr Gly Thr Gly Gln  Thr Thr Phe 
    1340                 1345                 1350             


Pro Ser  Ser Thr Ala Thr Phe  Leu Glu Thr Thr Thr  Leu Thr Pro 
    1355                 1360                 1365             


Thr Thr  Asp Phe Ser Thr Glu  Ser Leu Thr Thr Ala  Met Thr Ser 
    1370                 1375                 1380             


Thr Pro  Pro Ile Thr Ser Ser  Ile Thr Pro Thr Asp  Thr Met Thr 
    1385                 1390                 1395             


Ser Met  Arg Thr Thr Thr Ser  Trp Pro Thr Ala Thr  Asn Thr Leu 
    1400                 1405                 1410             


Ser Pro  Leu Thr Ser Ser Ile  Leu Ser Ser Thr Pro  Val Pro Ser 
    1415                 1420                 1425             


Thr Glu  Val Thr Thr Ser His  Thr Thr Asn Thr Asn  Pro Val Ser 
    1430                 1435                 1440             


Thr Leu  Val Thr Thr Leu Pro  Ile Thr Ile Thr Arg  Ser Thr Leu 
    1445                 1450                 1455             


Thr Ser  Glu Thr Ala Tyr Pro  Ser Ser Pro Thr Ser  Thr Val Thr 
    1460                 1465                 1470             


Glu Ser  Thr Thr Glu Ile Thr  Tyr Pro Thr Thr Met  Thr Glu Thr 
    1475                 1480                 1485             


Ser Ser  Thr Ala Thr Ser Leu  Pro Pro Thr Ser Ser  Leu Val Ser 
    1490                 1495                 1500             


Thr Ala  Glu Thr Ala Lys Thr  Pro Thr Thr Asn Leu  Val Thr Thr 
    1505                 1510                 1515             


Thr Thr  Lys Thr Thr Ser His  Ser Thr Thr Ser Phe  Thr Ser Ser 
    1520                 1525                 1530             


Thr Ile  Tyr Ser Thr Ala Ser  Thr Pro Thr Thr Ala  Ile Thr Ser 
    1535                 1540                 1545             


Val Pro  Thr Thr Leu Gly Thr  Met Val Thr Ser Thr  Ser Met Ile 
    1550                 1555                 1560             


Pro Ser  Thr Val Ser Thr Gly  Ile Pro Thr Ser Gln  Pro Thr Thr 
    1565                 1570                 1575             


Ile Thr  Pro Ser Ser Val Gly  Ile Ser Gly Ser Leu  Pro Met Met 
    1580                 1585                 1590             


Thr Asp  Leu Thr Ser Val Tyr  Thr Val Ser Ser Met  Ser Ala Arg 
    1595                 1600                 1605             


Pro Thr  Ser Val Ile Pro Ser  Ser Pro Thr Val Gln  Asn Thr Glu 
    1610                 1615                 1620             


Thr Ser  Ile Phe Val Ser Met  Met Ser Ala Thr Thr  Pro Ser Gly 
    1625                 1630                 1635             


Gly Pro  Thr Phe Thr Ser Thr  Glu Asn Thr Pro Thr  Arg Ser Leu 
    1640                 1645                 1650             


Leu Thr  Ser Phe Pro Val Thr  His Ser Phe Ser Ser  Ser Met Ser 
    1655                 1660                 1665             


Ala Ser  Ser Val Gly Thr Thr  His Thr Gln Ser Ile  Ser Ser Pro 
    1670                 1675                 1680             


Pro Ala  Ile Thr Ser Thr Leu  His Thr Thr Ala Glu  Ser Thr Pro 
    1685                 1690                 1695             


Ser Pro  Thr Thr Thr Met Ser  Phe Thr Thr Phe Thr  Lys Met Glu 
    1700                 1705                 1710             


Thr Pro  Ser Ser Thr Val Ala  Thr Thr Gly Thr Gly  Gln Thr Thr 
    1715                 1720                 1725             


Phe Thr  Ser Ser Thr Ala Thr  Ser Pro Lys Thr Thr  Thr Leu Thr 
    1730                 1735                 1740             


Pro Thr  Ser Asp Ile Ser Thr  Gly Ser Phe Lys Thr  Ala Val Ser 
    1745                 1750                 1755             


Ser Thr  Pro Pro Ile Thr Ser  Ser Ile Thr Ser Thr  Tyr Thr Val 
    1760                 1765                 1770             


Thr Ser  Met Thr Thr Thr Thr  Pro Leu Gly Pro Thr  Ala Thr Asn 
    1775                 1780                 1785             


Thr Leu  Pro Ser Phe Thr Ser  Ser Val Ser Ser Ser  Thr Pro Val 
    1790                 1795                 1800             


Pro Ser  Thr Glu Ala Ile Thr  Ser Gly Thr Thr Asn  Thr Thr Pro 
    1805                 1810                 1815             


Leu Ser  Thr Leu Val Thr Thr  Phe Ser Asn Ser Asp  Thr Ser Ser 
    1820                 1825                 1830             


Thr Pro  Thr Ser Glu Thr Thr  Tyr Pro Thr Ser Leu  Thr Ser Ala 
    1835                 1840                 1845             


Leu Thr  Asp Ser Thr Thr Arg  Thr Thr Tyr Ser Thr  Asn Met Thr 
    1850                 1855                 1860             


Gly Thr  Leu Ser Thr Val Thr  Ser Leu Arg Pro Thr  Ser Ser Ser 
    1865                 1870                 1875             


Leu Leu  Thr Thr Val Thr Ala  Thr Val Pro Thr Thr  Asn Leu Val 
    1880                 1885                 1890             


Thr Thr  Thr Thr Lys Ile Thr  Ser His Ser Thr Pro  Ser Phe Thr 
    1895                 1900                 1905             


Ser Ser  Ile Ala Thr Thr Glu  Thr Pro Ser His Ser  Thr Pro Arg 
    1910                 1915                 1920             


Phe Thr  Ser Ser Ile Thr Thr  Thr Glu Thr Pro Ser  His Ser Thr 
    1925                 1930                 1935             


Pro Arg  Phe Thr Ser Ser Ile  Thr Asn Thr Lys Thr  Thr Ser His 
    1940                 1945                 1950             


Ser Ser  Pro Ser Phe Thr Ser  Ser Ile Thr Thr Thr  Glu Thr Thr 
    1955                 1960                 1965             


Ser His  Asn Thr Pro Ser Leu  Thr Ser Ser Ile Thr  Thr Thr Lys 
    1970                 1975                 1980             


Thr Thr  Ser His Ser Thr Pro  Ser Tyr Thr Ser Leu  Ile Thr Thr 
    1985                 1990                 1995             


Thr Thr  Thr Thr Ser His Ser  Thr Pro Ser Phe Thr  Ser Ser Ile 
    2000                 2005                 2010             


Thr Thr  Thr Glu Thr Thr Ser  His Asn Thr Pro Ser  Leu Thr Ser 
    2015                 2020                 2025             


Ser Ile  Thr Thr Thr Glu Thr  Thr Ser His Ser Thr  Pro Ser Phe 
    2030                 2035                 2040             


Thr Ser  Ser Ile Thr Thr Glu  Thr Thr Ser His Ser  Thr Pro Ser 
    2045                 2050                 2055             


Phe Thr  Ser Leu Ile Thr Ile  Thr Glu Ile Thr Ser  His Ser Thr 
    2060                 2065                 2070             


Leu Ser  Tyr Thr Thr Ser Ile  Thr Thr Thr Glu Thr  Pro Ser His 
    2075                 2080                 2085             


Ser Thr  Leu Ser Phe Thr Ser  Ser Ile Thr Thr Thr  Glu Thr Thr 
    2090                 2095                 2100             


Ser His  Ser Thr Pro Ser Phe  Thr Ser Ser Ile Thr  Thr Ser Glu 
    2105                 2110                 2115             


Met Pro  Ser His Ser Thr Pro  Ser Phe Thr Ser Ser  Ile Thr Thr 
    2120                 2125                 2130             


Thr Glu  Asn Ala Thr His Ser  Thr Pro Asn Phe Thr  Ser Ser Ile 
    2135                 2140                 2145             


Thr Thr  Thr Glu Thr Thr Ser  His Ser Thr Pro Ser  Phe Thr Ser 
    2150                 2155                 2160             


Leu Ile  Thr Thr Thr Glu Thr  Thr Ser His Arg Trp  Gly Thr Thr 
    2165                 2170                 2175             


Glu Thr  Thr Ser Tyr Ser Thr  Pro Ser Phe Thr Ser  Ser Asn Thr 
    2180                 2185                 2190             


Ile Thr  Glu Thr Thr Ser His  Ser Thr Pro Ser Tyr  Ile Thr Ser 
    2195                 2200                 2205             


Ile Thr  Thr Thr Glu Thr Pro  Ser Ser Ser Thr Pro  Ser Phe Ser 
    2210                 2215                 2220             


Ser Ser  Ile Thr Thr Thr Glu  Thr Thr Ser His Ser  Thr Pro Gly 
    2225                 2230                 2235             


Phe Thr  Ser Ser Ile Thr Thr  Thr Glu Thr Thr Ser  His Ser Thr 
    2240                 2245                 2250             


Pro Ser  Phe Thr Ser Ser Ile  Thr Thr Thr Glu Thr  Thr Ser His 
    2255                 2260                 2265             


Asp Thr  Pro Ser Phe Thr Ser  Ser Ile Thr Thr Ser  Glu Thr Pro 
    2270                 2275                 2280             


Ser His  Ser Thr Pro Ser Ser  Thr Ser Leu Ile Thr  Thr Thr Lys 
    2285                 2290                 2295             


Thr Thr  Ser His Ser Thr Pro  Ser Phe Thr Ser Ser  Ile Thr Thr 
    2300                 2305                 2310             


Thr Glu  Thr Thr Ser His Ser  Ala His Ser Phe Thr  Ser Ser Ile 
    2315                 2320                 2325             


Thr Thr  Thr Glu Thr Thr Ser  His Asn Thr Arg Ser  Phe Thr Ser 
    2330                 2335                 2340             


Ser Ile  Thr Thr Thr Glu Thr  Asn Ser His Ser Thr  Thr Ser Phe 
    2345                 2350                 2355             


Thr Ser  Ser Ile Thr Thr Thr  Glu Thr Thr Ser His  Ser Thr Pro 
    2360                 2365                 2370             


Ser Phe  Ser Ser Ser Ile Thr  Thr Thr Glu Thr Pro  Leu His Ser 
    2375                 2380                 2385             


Thr Pro  Gly Leu Thr Ser Trp  Val Thr Thr Thr Lys  Thr Thr Ser 
    2390                 2395                 2400             


His Ile  Thr Pro Gly Leu Thr  Ser Ser Ile Thr Thr  Thr Glu Thr 
    2405                 2410                 2415             


Thr Ser  His Ser Thr Pro Gly  Phe Thr Ser Ser Ile  Thr Thr Thr 
    2420                 2425                 2430             


Glu Thr  Thr Ser Glu Ser Thr  Pro Ser Leu Ser Ser  Ser Thr Ile 
    2435                 2440                 2445             


Tyr Ser  Thr Val Ser Thr Ser  Thr Thr Ala Ile Thr  Ser His Phe 
    2450                 2455                 2460             


Thr Thr  Ser Glu Thr Ala Val  Thr Pro Thr Pro Val  Thr Pro Ser 
    2465                 2470                 2475             


Ser Leu  Ser Thr Asp Ile Pro  Thr Thr Ser Leu Arg  Thr Leu Thr 
    2480                 2485                 2490             


Pro Ser  Ser Val Gly Thr Ser  Thr Ser Leu Thr Thr  Thr Thr Asp 
    2495                 2500                 2505             


Phe Pro  Ser Ile Pro Thr Asp  Ile Ser Thr Leu Pro  Thr Arg Thr 
    2510                 2515                 2520             


His Ile  Ile Ser Ser Ser Pro  Ser Ile Gln Ser Thr  Glu Thr Ser 
    2525                 2530                 2535             


Ser Leu  Val Gly Thr Thr Ser  Pro Thr Met Ser Thr  Val Arg Met 
    2540                 2545                 2550             


Thr Leu  Arg Ile Thr Glu Asn  Thr Pro Ile Ser Ser  Phe Ser Thr 
    2555                 2560                 2565             


Ser Ile  Val Val Ile Pro Glu  Thr Pro Thr Gln Thr  Pro Pro Val 
    2570                 2575                 2580             


Leu Thr  Ser Ala Thr Gly Thr  Gln Thr Ser Pro Ala  Pro Thr Thr 
    2585                 2590                 2595             


Val Thr  Phe Gly Ser Thr Asp  Ser Ser Thr Ser Thr  Leu His Thr 
    2600                 2605                 2610             


Leu Thr  Pro Ser Thr Ala Leu  Ser Thr Ile Val Ser  Thr Ser Gln 
    2615                 2620                 2625             


Val Pro  Ile Pro Ser Thr His  Ser Ser Thr Leu Gln  Thr Thr Pro 
    2630                 2635                 2640             


Ser Thr  Pro Ser Leu Gln Thr  Ser Leu Thr Ser Thr  Ser Glu Phe 
    2645                 2650                 2655             


Thr Thr  Glu Ser Phe Thr Arg  Gly Ser Thr Ser Thr  Asn Ala Ile 
    2660                 2665                 2670             


Leu Thr  Ser Phe Ser Thr Ile  Ile Trp Ser Ser Thr  Pro Thr Ile 
    2675                 2680                 2685             


Ile Met  Ser Ser Ser Pro Ser  Ser Ala Ser Ile Thr  Pro Val Phe 
    2690                 2695                 2700             


Ser Thr  Thr Ile His Ser Val  Pro Ser Ser Pro Tyr  Ile Phe Ser 
    2705                 2710                 2715             


Thr Glu  Asn Val Gly Ser Ala  Ser Ile Thr Gly Phe  Pro Ser Leu 
    2720                 2725                 2730             


Ser Ser  Ser Ala Thr Thr Ser  Thr Ser Ser Thr Ser  Ser Ser Leu 
    2735                 2740                 2745             


Thr Thr  Ala Leu Thr Glu Ile  Thr Pro Phe Ser Tyr  Ile Ser Leu 
    2750                 2755                 2760             


Pro Ser  Thr Thr Pro Cys Pro  Gly Thr Ile Thr Ile  Thr Ile Val 
    2765                 2770                 2775             


Pro Ala  Ser Pro Thr Asp Pro  Cys Val Glu Met Asp  Pro Ser Thr 
    2780                 2785                 2790             


Glu Ala  Thr Ser Pro Pro Thr  Thr Pro Leu Thr Val  Phe Pro Phe 
    2795                 2800                 2805             


Thr Thr  Glu Met Val Thr Cys  Pro Thr Ser Ile Ser  Ile Gln Thr 
    2810                 2815                 2820             


Thr Leu  Thr Thr Tyr Met Asp  Thr Ser Ser Met Met  Pro Glu Ser 
    2825                 2830                 2835             


Glu Ser  Ser Ile Ser Pro Asn  Ala Ser Ser Ser Thr  Gly Thr Gly 
    2840                 2845                 2850             


Thr Val  Pro Thr Asn Thr Val  Phe Thr Ser Thr Arg  Leu Pro Thr 
    2855                 2860                 2865             


Ser Glu  Thr Trp Leu Ser Asn  Ser Ser Val Ile Pro  Leu Pro Leu 
    2870                 2875                 2880             


Pro Gly  Val Ser Thr Ile Pro  Leu Thr Met Lys Pro  Ser Ser Ser 
    2885                 2890                 2895             


Leu Pro  Thr Ile Leu Arg Thr  Ser Ser Lys Ser Thr  His Pro Ser 
    2900                 2905                 2910             


Pro Pro  Thr Thr Arg Thr Ser  Glu Thr Pro Val Ala  Thr Thr Gln 
    2915                 2920                 2925             


Thr Pro  Thr Thr Leu Thr Ser  Arg Arg Thr Thr Arg  Ile Thr Ser 
    2930                 2935                 2940             


Gln Met  Thr Thr Gln Ser Thr  Leu Thr Thr Thr Ala  Gly Thr Cys 
    2945                 2950                 2955             


Asp Asn  Gly Gly Thr Trp Glu  Gln Gly Gln Cys Ala  Cys Leu Pro 
    2960                 2965                 2970             


Gly Phe  Ser Gly Asp Arg Cys  Gln Leu Gln Thr Arg  Cys Gln Asn 
    2975                 2980                 2985             


Gly Gly  Gln Trp Asp Gly Leu  Lys Cys Gln Cys Pro  Ser Thr Phe 
    2990                 2995                 3000             


Tyr Gly  Ser Ser Cys Glu Phe  Ala Val Glu Gln Val  Asp Leu Asp 
    3005                 3010                 3015             


Val Val  Glu Thr Glu Val Gly  Met Glu Val Ser Val  Asp Gln Gln 
    3020                 3025                 3030             


Phe Ser  Pro Asp Leu Asn Asp  Asn Thr Ser Gln Ala  Tyr Arg Asp 
    3035                 3040                 3045             


Phe Asn  Lys Thr Phe Trp Asn  Gln Met Gln Lys Ile  Phe Ala Asp 
    3050                 3055                 3060             


Met Gln  Gly Phe Thr Phe Lys  Gly Val Glu Ile Leu  Ser Leu Arg 
    3065                 3070                 3075             


Asn Gly  Ser Ile Val Val Asp  Tyr Leu Val Leu Leu  Glu Met Pro 
    3080                 3085                 3090             


Phe Ser  Pro Gln Leu Glu Ser  Glu Tyr Glu Gln Val  Lys Thr Thr 
    3095                 3100                 3105             


Leu Lys  Glu Gly Leu Gln Asn  Ala Ser Gln Asp Val  Asn Ser Cys 
    3110                 3115                 3120             


Gln Asp  Ser Gln Thr Leu Cys  Phe Lys Pro Asp Ser  Ile Lys Val 
    3125                 3130                 3135             


Asn Asn  Asn Ser Lys Thr Glu  Leu Thr Pro Ala Ala  Ile Cys Arg 
    3140                 3145                 3150             


Arg Ala  Ala Pro Thr Gly Tyr  Glu Glu Phe Tyr Phe  Pro Leu Val 
    3155                 3160                 3165             


Glu Ala  Thr Arg Leu Arg Cys  Val Thr Lys Cys Thr  Ser Gly Val 
    3170                 3175                 3180             


Asp Asn  Ala Ile Asp Cys His  Gln Gly Gln Cys Val  Leu Glu Thr 
    3185                 3190                 3195             


Ser Gly  Pro Thr Cys Arg Cys  Tyr Ser Thr Asp Thr  His Trp Phe 
    3200                 3205                 3210             


Ser Gly  Pro Arg Cys Glu Val  Ala Val His Trp Arg  Ala Leu Val 
    3215                 3220                 3225             


Gly Gly  Leu Thr Ala Gly Ala  Ala Leu Leu Val Leu  Leu Leu Leu 
    3230                 3235                 3240             


Ala Leu  Gly Val Arg Ala Val  Arg Ser Gly Trp Trp  Gly Gly Gln 
    3245                 3250                 3255             


Arg Arg  Gly Arg Ser Trp Asp  Gln Asp Arg Lys Trp  Phe Glu Thr 
    3260                 3265                 3270             


Trp Asp  Glu Glu Val Val Gly  Thr Phe Ser Asn Trp  Gly Phe Glu 
    3275                 3280                 3285             


Asp Asp  Gly Thr Asp Lys Asp  Thr Asn Phe Tyr Val  Ala Leu Glu 
    3290                 3295                 3300             


Asn Val  Asp Thr Thr Met Lys  Val His Ile Lys Arg  Pro Glu Met 
    3305                 3310                 3315             


Thr Ser  Ser Ser Val 
    3320             


<210>  9103
<211>  3265
<212>  PRT
<213>  Homo Sapiens

<400>  9103

Met Gln Leu Leu Gly Leu Leu Gly Leu Leu Trp Met Leu Lys Ala Ser 
1               5                   10                  15      


Pro Trp Ala Thr Gly Thr Leu Ser Thr Ala Thr Ser Ile Ser Gln Val 
            20                  25                  30          


Pro Phe Pro Arg Ala Glu Ala Ala Ser Ala Val Leu Ser Asn Ser Pro 
        35                  40                  45              


His Ser Arg Asp Leu Ala Gly Trp Pro Leu Gly Val Pro Gln Leu Ala 
    50                  55                  60                  


Ser Pro Ala Pro Gly His Arg Glu Asn Ala Pro Met Thr Leu Thr Thr 
65                  70                  75                  80  


Ser Pro His Asp Thr Leu Ile Ser Glu Thr Leu Leu Asn Ser Pro Val 
                85                  90                  95      


Ser Ser Asn Thr Ser Thr Thr Pro Thr Ser Lys Phe Ala Phe Lys Val 
            100                 105                 110         


Glu Thr Thr Pro Pro Thr Val Leu Val Tyr Ser Ala Thr Thr Glu Cys 
        115                 120                 125             


Val Tyr Pro Thr Ser Phe Ile Ile Thr Ile Ser His Pro Thr Ser Ile 
    130                 135                 140                 


Cys Val Thr Thr Thr Gln Val Ala Phe Thr Ser Ser Tyr Thr Ser Thr 
145                 150                 155                 160 


Pro Val Thr Gln Lys Pro Val Thr Thr Val Thr Ser Thr Tyr Ser Met 
                165                 170                 175     


Thr Thr Thr Glu Lys Gly Thr Ser Ala Met Thr Ser Ser Pro Ser Thr 
            180                 185                 190         


Thr Thr Ala Arg Glu Thr Pro Ile Val Thr Val Thr Pro Ser Ser Val 
        195                 200                 205             


Ser Ala Thr Asp Thr Thr Phe His Thr Thr Ile Ser Ser Thr Thr Arg 
    210                 215                 220                 


Thr Thr Glu Arg Thr Pro Leu Pro Thr Gly Ser Ile His Thr Thr Thr 
225                 230                 235                 240 


Ser Pro Thr Pro Val Phe Thr Thr Leu Lys Thr Ala Val Thr Ser Thr 
                245                 250                 255     


Ser Pro Ile Thr Ser Ser Ile Thr Ser Thr Asn Thr Val Thr Ser Met 
            260                 265                 270         


Thr Thr Thr Ala Ser Gln Pro Thr Ala Thr Asn Thr Leu Ser Ser Pro 
        275                 280                 285             


Thr Arg Thr Ile Leu Ser Ser Thr Pro Val Leu Ser Thr Glu Thr Ile 
    290                 295                 300                 


Thr Ser Gly Ile Thr Asn Thr Thr Pro Leu Ser Thr Leu Val Thr Thr 
305                 310                 315                 320 


Leu Pro Thr Thr Ile Ser Arg Ser Thr Pro Thr Ser Glu Thr Thr Tyr 
                325                 330                 335     


Thr Thr Ser Pro Thr Ser Thr Val Thr Asp Ser Thr Thr Lys Ile Ala 
            340                 345                 350         


Tyr Ser Thr Ser Met Thr Gly Thr Leu Ser Thr Glu Thr Ser Leu Pro 
        355                 360                 365             


Pro Thr Ser Ser Ser Leu Pro Thr Thr Glu Thr Ala Thr Thr Pro Met 
    370                 375                 380                 


Thr Asn Leu Val Thr Thr Thr Thr Glu Ile Ser Ser His Ser Thr Pro 
385                 390                 395                 400 


Ser Phe Ser Ser Ser Thr Ile Tyr Ser Thr Val Ser Thr Ser Thr Thr 
                405                 410                 415     


Ala Ile Ser Ser Leu Pro Pro Thr Ser Gly Thr Met Val Thr Ser Thr 
            420                 425                 430         


Thr Met Thr Pro Ser Ser Leu Ser Thr Asp Ile Pro Phe Thr Thr Pro 
        435                 440                 445             


Thr Thr Ile Thr His His Ser Val Gly Ser Thr Gly Phe Leu Thr Thr 
    450                 455                 460                 


Ala Thr Asp Leu Thr Ser Thr Phe Thr Val Ser Ser Ser Ser Ala Met 
465                 470                 475                 480 


Ser Thr Ser Val Ile Pro Ser Ser Pro Ser Ile Gln Asn Thr Glu Thr 
                485                 490                 495     


Ser Ser Leu Val Ser Met Thr Ser Ala Thr Thr Pro Asn Val Arg Pro 
            500                 505                 510         


Thr Phe Val Ser Thr Leu Ser Thr Pro Thr Ser Ser Leu Leu Thr Thr 
        515                 520                 525             


Phe Pro Ala Thr Tyr Ser Phe Ser Ser Ser Met Ser Ala Ser Ser Ala 
    530                 535                 540                 


Gly Thr Thr His Thr Glu Ser Ile Ser Ser Pro Pro Ala Ser Thr Ser 
545                 550                 555                 560 


Thr Leu His Thr Thr Ala Glu Ser Thr Leu Ala Pro Thr Thr Thr Thr 
                565                 570                 575     


Ser Phe Thr Thr Ser Thr Thr Met Glu Pro Pro Ser Thr Thr Ala Ala 
            580                 585                 590         


Thr Thr Gly Thr Gly Gln Thr Thr Phe Thr Ser Ser Thr Ala Thr Phe 
        595                 600                 605             


Pro Glu Thr Thr Thr Pro Thr Pro Thr Thr Asp Met Ser Thr Glu Ser 
    610                 615                 620                 


Leu Thr Thr Ala Met Thr Ser Pro Pro Ile Thr Ser Ser Val Thr Ser 
625                 630                 635                 640 


Thr Asn Thr Val Thr Ser Met Thr Thr Thr Thr Ser Pro Pro Thr Thr 
                645                 650                 655     


Thr Asn Ser Phe Thr Ser Leu Thr Ser Met Pro Leu Ser Ser Thr Pro 
            660                 665                 670         


Val Pro Ser Thr Glu Val Val Thr Ser Gly Thr Ile Asn Thr Ile Pro 
        675                 680                 685             


Pro Ser Ile Leu Val Thr Thr Leu Pro Thr Pro Asn Ala Ser Ser Met 
    690                 695                 700                 


Thr Thr Ser Glu Thr Thr Tyr Pro Asn Ser Pro Thr Gly Pro Gly Thr 
705                 710                 715                 720 


Asn Ser Thr Thr Glu Ile Thr Tyr Pro Thr Thr Met Thr Glu Thr Ser 
                725                 730                 735     


Ser Thr Ala Thr Ser Leu Pro Pro Thr Ser Pro Leu Val Ser Thr Ala 
            740                 745                 750         


Lys Thr Ala Lys Thr Pro Thr Thr Asn Leu Val Thr Thr Thr Thr Lys 
        755                 760                 765             


Thr Thr Ser His Ser Thr Thr Ser Phe Thr Ser Ser Thr Val Tyr Ser 
    770                 775                 780                 


Thr Ala Ser Thr Tyr Thr Thr Ala Ile Thr Ser Val Pro Thr Thr Leu 
785                 790                 795                 800 


Gly Thr Met Val Thr Ser Thr Ser Met Ile Ser Ser Thr Val Ser Thr 
                805                 810                 815     


Gly Ile Pro Thr Ser Gln Pro Thr Thr Ile Thr Pro Ser Ser Val Gly 
            820                 825                 830         


Ile Ser Gly Ser Leu Pro Met Met Thr Asp Leu Thr Ser Val Tyr Thr 
        835                 840                 845             


Val Ser Asn Met Ser Ala Arg Pro Thr Thr Val Ile Pro Ser Ser Pro 
    850                 855                 860                 


Thr Val Gln Asn Thr Glu Ile Ser Ile Ser Val Ser Met Thr Ser Ala 
865                 870                 875                 880 


Thr Thr Pro Ser Gly Gly Pro Thr Phe Thr Ser Thr Glu Asn Thr Pro 
                885                 890                 895     


Thr Arg Ser Leu Leu Thr Ser Phe Pro Met Thr His Ser Phe Ser Ser 
            900                 905                 910         


Ser Met Ser Glu Ser Ser Ala Gly Thr Thr His Thr Glu Ser Ile Ser 
        915                 920                 925             


Ser Pro Arg Gly Thr Thr Ser Thr Leu His Thr Thr Val Glu Ser Thr 
    930                 935                 940                 


Pro Ser Pro Thr Thr Thr Thr Ser Phe Thr Thr Ser Thr Met Met Glu 
945                 950                 955                 960 


Pro Pro Ser Ser Thr Val Ser Thr Thr Gly Arg Gly Gln Thr Thr Phe 
                965                 970                 975     


Pro Ser Ser Thr Ala Thr Phe Pro Glu Thr Thr Thr Leu Thr Pro Thr 
            980                 985                 990         


Thr Asp Ile Ser Thr Val Ser Leu  Thr Thr Ala Met Thr  Ser Pro Pro 
        995                 1000                 1005             


Pro Val  Ser Ser Ser Ile Thr  Pro Thr Asn Thr Met  Thr Ser Met 
    1010                 1015                 1020             


Arg Thr  Thr Thr Tyr Trp Pro  Thr Ala Thr Asn Thr  Leu Ser Pro 
    1025                 1030                 1035             


Leu Thr  Ser Ser Ile Leu Ser  Ser Thr Pro Val Pro  Ser Thr Glu 
    1040                 1045                 1050             


Met Ile  Thr Ser His Thr Thr  Asn Thr Thr Pro Leu  Ser Thr Leu 
    1055                 1060                 1065             


Val Thr  Thr Leu Leu Thr Thr  Ile Thr Arg Ser Thr  Pro Thr Ser 
    1070                 1075                 1080             


Glu Thr  Thr Tyr Pro Thr Ser  Pro Thr Ser Ile Val  Ser Asp Ser 
    1085                 1090                 1095             


Thr Thr  Glu Ile Thr Tyr Ser  Thr Ser Ile Thr Gly  Thr Leu Ser 
    1100                 1105                 1110             


Thr Ala  Thr Thr Leu Pro Pro  Thr Ser Ser Ser Leu  Pro Thr Thr 
    1115                 1120                 1125             


Glu Thr  Ala Thr Met Thr Pro  Thr Thr Thr Leu Ile  Thr Thr Thr 
    1130                 1135                 1140             


Pro Asn  Thr Thr Ser Leu Ser  Thr Pro Ser Phe Thr  Ser Ser Thr 
    1145                 1150                 1155             


Ile Tyr  Ser Thr Val Ser Thr  Ser Thr Thr Ala Ile  Ser Ser Ala 
    1160                 1165                 1170             


Ser Pro  Thr Ser Gly Thr Met  Val Thr Ser Thr Thr  Met Thr Pro 
    1175                 1180                 1185             


Ser Ser  Leu Ser Thr Asp Thr  Pro Ser Thr Thr Pro  Thr Thr Ile 
    1190                 1195                 1200             


Thr Tyr  Pro Ser Val Gly Ser  Thr Gly Phe Leu Thr  Thr Ala Thr 
    1205                 1210                 1215             


Asp Leu  Thr Ser Thr Phe Thr  Val Ser Ser Ser Ser  Ala Met Ser 
    1220                 1225                 1230             


Thr Ser  Val Ile Pro Ser Ser  Pro Ser Ile Gln Asn  Thr Glu Thr 
    1235                 1240                 1245             


Ser Ser  Leu Val Ser Met Thr  Ser Ala Thr Thr Pro  Ser Leu Arg 
    1250                 1255                 1260             


Pro Thr  Ile Thr Ser Thr Asp  Ser Thr Leu Thr Ser  Ser Leu Leu 
    1265                 1270                 1275             


Thr Thr  Phe Pro Ser Thr Tyr  Ser Phe Ser Ser Ser  Met Ser Ala 
    1280                 1285                 1290             


Ser Ser  Ala Gly Thr Thr His  Thr Glu Thr Ile Ser  Ser Leu Pro 
    1295                 1300                 1305             


Ala Ser  Thr Asn Thr Ile His  Thr Thr Ala Glu Ser  Ala Leu Ala 
    1310                 1315                 1320             


Pro Thr  Thr Thr Thr Ser Phe  Thr Thr Ser Pro Thr  Met Glu Pro 
    1325                 1330                 1335             


Pro Ser  Thr Thr Val Ala Thr  Thr Gly Thr Gly Gln  Thr Thr Phe 
    1340                 1345                 1350             


Pro Ser  Ser Thr Ala Thr Phe  Leu Glu Thr Thr Thr  Leu Thr Pro 
    1355                 1360                 1365             


Thr Thr  Asp Phe Ser Thr Glu  Ser Leu Thr Thr Ala  Met Thr Ser 
    1370                 1375                 1380             


Thr Pro  Pro Ile Thr Ser Ser  Ile Thr Pro Thr Asp  Thr Met Thr 
    1385                 1390                 1395             


Ser Met  Arg Thr Thr Thr Ser  Trp Pro Thr Ala Thr  Asn Thr Leu 
    1400                 1405                 1410             


Ser Pro  Leu Thr Ser Ser Ile  Leu Ser Ser Thr Pro  Val Pro Ser 
    1415                 1420                 1425             


Thr Glu  Val Thr Thr Ser His  Thr Thr Asn Thr Asn  Pro Val Ser 
    1430                 1435                 1440             


Thr Leu  Val Thr Thr Leu Pro  Ile Thr Ile Thr Arg  Ser Thr Leu 
    1445                 1450                 1455             


Thr Ser  Glu Thr Ala Tyr Pro  Ser Ser Pro Thr Ser  Thr Val Thr 
    1460                 1465                 1470             


Glu Ser  Thr Thr Glu Ile Thr  Tyr Pro Thr Thr Met  Thr Glu Thr 
    1475                 1480                 1485             


Ser Ser  Thr Ala Thr Ser Leu  Pro Pro Thr Ser Ser  Leu Val Ser 
    1490                 1495                 1500             


Thr Ala  Glu Thr Ala Lys Thr  Pro Thr Thr Asn Leu  Val Thr Thr 
    1505                 1510                 1515             


Thr Thr  Lys Thr Thr Ser His  Ser Thr Thr Ser Phe  Thr Ser Ser 
    1520                 1525                 1530             


Thr Ile  Tyr Ser Thr Ala Ser  Thr Pro Thr Thr Ala  Ile Thr Ser 
    1535                 1540                 1545             


Val Pro  Thr Thr Leu Gly Thr  Met Val Thr Ser Thr  Ser Met Ile 
    1550                 1555                 1560             


Pro Ser  Thr Val Ser Thr Gly  Ile Pro Thr Ser Gln  Pro Thr Thr 
    1565                 1570                 1575             


Ile Thr  Pro Ser Ser Val Gly  Ile Ser Gly Ser Leu  Pro Met Met 
    1580                 1585                 1590             


Thr Asp  Leu Thr Ser Val Tyr  Thr Val Ser Ser Met  Ser Ala Arg 
    1595                 1600                 1605             


Pro Thr  Ser Val Ile Pro Ser  Ser Pro Thr Val Gln  Asn Thr Glu 
    1610                 1615                 1620             


Thr Ser  Ile Phe Val Ser Met  Met Ser Ala Thr Thr  Pro Ser Gly 
    1625                 1630                 1635             


Gly Pro  Thr Phe Thr Ser Thr  Glu Asn Thr Pro Thr  Arg Ser Leu 
    1640                 1645                 1650             


Leu Thr  Ser Phe Pro Val Thr  His Ser Phe Ser Ser  Ser Met Ser 
    1655                 1660                 1665             


Ala Ser  Ser Val Gly Thr Thr  His Thr Gln Ser Ile  Ser Ser Pro 
    1670                 1675                 1680             


Pro Ala  Ile Thr Ser Thr Leu  His Thr Thr Ala Glu  Ser Thr Pro 
    1685                 1690                 1695             


Ser Pro  Thr Thr Thr Met Ser  Phe Thr Thr Phe Thr  Lys Met Glu 
    1700                 1705                 1710             


Thr Pro  Ser Ser Thr Val Ala  Thr Thr Gly Thr Gly  Gln Thr Thr 
    1715                 1720                 1725             


Phe Thr  Ser Ser Thr Ala Thr  Ser Pro Lys Thr Thr  Thr Leu Thr 
    1730                 1735                 1740             


Pro Thr  Ser Asp Ile Ser Thr  Gly Ser Phe Lys Thr  Ala Val Ser 
    1745                 1750                 1755             


Ser Thr  Pro Pro Ile Thr Ser  Ser Ile Thr Ser Thr  Tyr Thr Val 
    1760                 1765                 1770             


Thr Ser  Met Thr Thr Thr Thr  Pro Leu Gly Pro Thr  Ala Thr Asn 
    1775                 1780                 1785             


Thr Leu  Pro Ser Phe Thr Ser  Ser Val Ser Ser Ser  Thr Pro Val 
    1790                 1795                 1800             


Pro Ser  Thr Glu Ala Ile Thr  Ser Gly Thr Thr Asn  Thr Thr Pro 
    1805                 1810                 1815             


Leu Ser  Thr Leu Val Thr Thr  Phe Ser Asn Ser Asp  Thr Ser Ser 
    1820                 1825                 1830             


Thr Pro  Thr Ser Glu Thr Thr  Tyr Pro Thr Ser Leu  Thr Ser Ala 
    1835                 1840                 1845             


Leu Thr  Asp Ser Thr Thr Arg  Thr Thr Tyr Ser Thr  Asn Met Thr 
    1850                 1855                 1860             


Gly Thr  Leu Ser Thr Val Thr  Ser Leu Arg Pro Thr  Ser Ser Ser 
    1865                 1870                 1875             


Leu Leu  Thr Thr Val Thr Ala  Thr Val Pro Thr Thr  Asn Leu Val 
    1880                 1885                 1890             


Thr Thr  Thr Thr Lys Ile Thr  Ser His Ser Thr Pro  Ser Phe Thr 
    1895                 1900                 1905             


Ser Ser  Ile Ala Thr Thr Glu  Thr Pro Ser His Ser  Thr Pro Arg 
    1910                 1915                 1920             


Phe Thr  Ser Ser Ile Thr Thr  Thr Glu Thr Pro Ser  His Ser Thr 
    1925                 1930                 1935             


Pro Arg  Phe Thr Ser Ser Ile  Thr Asn Thr Lys Thr  Thr Ser His 
    1940                 1945                 1950             


Ser Ser  Pro Ser Phe Thr Ser  Ser Ile Thr Thr Thr  Glu Thr Thr 
    1955                 1960                 1965             


Ser His  Asn Thr Pro Ser Leu  Thr Ser Ser Ile Thr  Thr Thr Lys 
    1970                 1975                 1980             


Thr Thr  Ser His Ser Thr Pro  Ser Tyr Thr Ser Leu  Ile Thr Thr 
    1985                 1990                 1995             


Thr Thr  Thr Thr Ser His Ser  Thr Pro Ser Phe Thr  Ser Ser Ile 
    2000                 2005                 2010             


Thr Thr  Thr Glu Thr Thr Ser  His Asn Thr Pro Ser  Leu Thr Ser 
    2015                 2020                 2025             


Ser Ile  Thr Thr Thr Glu Thr  Thr Ser His Ser Thr  Pro Ser Phe 
    2030                 2035                 2040             


Thr Ser  Ser Ile Thr Thr Glu  Thr Thr Ser His Ser  Thr Pro Ser 
    2045                 2050                 2055             


Phe Thr  Ser Leu Ile Thr Ile  Thr Glu Ile Thr Ser  His Ser Thr 
    2060                 2065                 2070             


Leu Ser  Tyr Thr Thr Ser Ile  Thr Thr Thr Glu Thr  Pro Ser His 
    2075                 2080                 2085             


Ser Thr  Leu Ser Phe Thr Ser  Ser Ile Thr Thr Thr  Glu Thr Thr 
    2090                 2095                 2100             


Ser His  Ser Thr Pro Ser Phe  Thr Ser Ser Ile Thr  Thr Ser Glu 
    2105                 2110                 2115             


Met Pro  Ser His Ser Thr Pro  Ser Phe Thr Ser Ser  Ile Thr Thr 
    2120                 2125                 2130             


Thr Glu  Asn Ala Thr His Ser  Thr Pro Asn Phe Thr  Ser Ser Ile 
    2135                 2140                 2145             


Thr Thr  Thr Glu Thr Thr Ser  His Ser Thr Pro Ser  Phe Thr Ser 
    2150                 2155                 2160             


Leu Ile  Thr Thr Thr Glu Thr  Thr Ser His Arg Trp  Gly Thr Thr 
    2165                 2170                 2175             


Glu Thr  Thr Ser Tyr Ser Thr  Pro Ser Phe Thr Ser  Ser Asn Thr 
    2180                 2185                 2190             


Ile Thr  Glu Thr Thr Ser His  Ser Thr Pro Ser Tyr  Ile Thr Ser 
    2195                 2200                 2205             


Ile Thr  Thr Thr Glu Thr Pro  Ser Ser Ser Thr Pro  Ser Phe Ser 
    2210                 2215                 2220             


Ser Ser  Ile Thr Thr Thr Glu  Thr Thr Ser His Ser  Thr Pro Gly 
    2225                 2230                 2235             


Phe Thr  Ser Ser Ile Thr Thr  Thr Glu Thr Thr Ser  His Ser Thr 
    2240                 2245                 2250             


Pro Ser  Phe Thr Ser Ser Ile  Thr Thr Thr Glu Thr  Thr Ser His 
    2255                 2260                 2265             


Asp Thr  Pro Ser Phe Thr Ser  Ser Ile Thr Thr Ser  Glu Thr Pro 
    2270                 2275                 2280             


Ser His  Ser Thr Pro Ser Ser  Thr Ser Leu Ile Thr  Thr Thr Lys 
    2285                 2290                 2295             


Thr Thr  Ser His Ser Thr Pro  Ser Phe Thr Ser Ser  Ile Thr Thr 
    2300                 2305                 2310             


Thr Glu  Thr Thr Ser His Ser  Ala His Ser Phe Thr  Ser Ser Ile 
    2315                 2320                 2325             


Thr Thr  Thr Glu Thr Thr Ser  His Asn Thr Arg Ser  Phe Thr Ser 
    2330                 2335                 2340             


Ser Ile  Thr Thr Thr Glu Thr  Asn Ser His Ser Thr  Thr Ser Phe 
    2345                 2350                 2355             


Thr Ser  Ser Ile Thr Thr Thr  Glu Thr Thr Ser His  Ser Thr Pro 
    2360                 2365                 2370             


Ser Phe  Ser Ser Ser Ile Thr  Thr Thr Glu Thr Pro  Leu His Ser 
    2375                 2380                 2385             


Thr Pro  Gly Leu Thr Ser Trp  Val Thr Thr Thr Lys  Thr Thr Ser 
    2390                 2395                 2400             


His Ile  Thr Pro Gly Leu Thr  Ser Ser Ile Thr Thr  Thr Glu Thr 
    2405                 2410                 2415             


Thr Ser  His Ser Thr Pro Gly  Phe Thr Ser Ser Ile  Thr Thr Thr 
    2420                 2425                 2430             


Glu Thr  Thr Ser Glu Ser Thr  Pro Ser Leu Ser Ser  Ser Thr Ile 
    2435                 2440                 2445             


Tyr Ser  Thr Val Ser Thr Ser  Thr Thr Ala Ile Thr  Ser His Phe 
    2450                 2455                 2460             


Thr Thr  Ser Glu Thr Ala Val  Thr Pro Thr Pro Val  Thr Pro Ser 
    2465                 2470                 2475             


Ser Leu  Ser Thr Asp Ile Pro  Thr Thr Ser Leu Arg  Thr Leu Thr 
    2480                 2485                 2490             


Pro Ser  Ser Val Gly Thr Ser  Thr Ser Leu Thr Thr  Thr Thr Asp 
    2495                 2500                 2505             


Phe Pro  Ser Ile Pro Thr Asp  Ile Ser Thr Leu Pro  Thr Arg Thr 
    2510                 2515                 2520             


His Ile  Ile Ser Ser Ser Pro  Ser Ile Gln Ser Thr  Glu Thr Ser 
    2525                 2530                 2535             


Ser Leu  Val Gly Thr Thr Ser  Pro Thr Met Ser Thr  Val Arg Met 
    2540                 2545                 2550             


Thr Leu  Arg Ile Thr Glu Asn  Thr Pro Ile Ser Ser  Phe Ser Thr 
    2555                 2560                 2565             


Ser Ile  Val Val Ile Pro Glu  Thr Pro Thr Gln Thr  Pro Pro Val 
    2570                 2575                 2580             


Leu Thr  Ser Ala Thr Gly Thr  Gln Thr Ser Pro Ala  Pro Thr Thr 
    2585                 2590                 2595             


Val Thr  Phe Gly Ser Thr Asp  Ser Ser Thr Ser Thr  Leu His Thr 
    2600                 2605                 2610             


Leu Thr  Pro Ser Thr Ala Leu  Ser Thr Ile Val Ser  Thr Ser Gln 
    2615                 2620                 2625             


Val Pro  Ile Pro Ser Thr His  Ser Ser Thr Leu Gln  Thr Thr Pro 
    2630                 2635                 2640             


Ser Thr  Pro Ser Leu Gln Thr  Ser Leu Thr Ser Thr  Ser Glu Phe 
    2645                 2650                 2655             


Thr Thr  Glu Ser Phe Thr Arg  Gly Ser Thr Ser Thr  Asn Ala Ile 
    2660                 2665                 2670             


Leu Thr  Ser Phe Ser Thr Ile  Ile Trp Ser Ser Thr  Pro Thr Ile 
    2675                 2680                 2685             


Ile Met  Ser Ser Ser Pro Ser  Ser Ala Ser Ile Thr  Pro Val Phe 
    2690                 2695                 2700             


Ser Thr  Thr Ile His Ser Val  Pro Ser Ser Pro Tyr  Ile Phe Ser 
    2705                 2710                 2715             


Thr Glu  Asn Val Gly Ser Ala  Ser Ile Thr Gly Phe  Pro Ser Leu 
    2720                 2725                 2730             


Ser Ser  Ser Ala Thr Thr Ser  Thr Ser Ser Thr Ser  Ser Ser Leu 
    2735                 2740                 2745             


Thr Thr  Ala Leu Thr Glu Ile  Thr Pro Phe Ser Tyr  Ile Ser Leu 
    2750                 2755                 2760             


Pro Ser  Thr Thr Pro Cys Pro  Gly Thr Ile Thr Ile  Thr Ile Val 
    2765                 2770                 2775             


Pro Ala  Ser Pro Thr Asp Pro  Cys Val Glu Met Asp  Pro Ser Thr 
    2780                 2785                 2790             


Glu Ala  Thr Ser Pro Pro Thr  Thr Pro Leu Thr Val  Phe Pro Phe 
    2795                 2800                 2805             


Thr Thr  Glu Met Val Thr Cys  Pro Thr Ser Ile Ser  Ile Gln Thr 
    2810                 2815                 2820             


Thr Leu  Thr Thr Tyr Met Asp  Thr Ser Ser Met Met  Pro Glu Ser 
    2825                 2830                 2835             


Glu Ser  Ser Ile Ser Pro Asn  Ala Ser Ser Ser Thr  Gly Thr Gly 
    2840                 2845                 2850             


Thr Val  Pro Thr Asn Thr Val  Phe Thr Ser Thr Arg  Leu Pro Thr 
    2855                 2860                 2865             


Ser Glu  Thr Trp Leu Ser Asn  Ser Ser Val Ile Pro  Leu Pro Leu 
    2870                 2875                 2880             


Pro Gly  Val Ser Thr Ile Pro  Leu Thr Met Lys Pro  Ser Ser Ser 
    2885                 2890                 2895             


Leu Pro  Thr Ile Leu Arg Thr  Ser Ser Lys Ser Thr  His Pro Ser 
    2900                 2905                 2910             


Pro Pro  Thr Thr Arg Thr Ser  Glu Thr Pro Val Ala  Thr Thr Gln 
    2915                 2920                 2925             


Thr Pro  Thr Thr Leu Thr Ser  Arg Arg Thr Thr Arg  Ile Thr Ser 
    2930                 2935                 2940             


Gln Met  Thr Thr Gln Ser Thr  Leu Thr Thr Thr Ala  Gly Thr Cys 
    2945                 2950                 2955             


Asp Asn  Gly Gly Thr Trp Glu  Gln Gly Gln Cys Ala  Cys Leu Pro 
    2960                 2965                 2970             


Gly Phe  Ser Gly Asp Arg Cys  Gln Leu Gln Thr Arg  Cys Gln Asn 
    2975                 2980                 2985             


Gly Gly  Gln Trp Asp Gly Leu  Lys Cys Gln Cys Pro  Ser Thr Phe 
    2990                 2995                 3000             


Tyr Gly  Ser Ser Cys Glu Phe  Ala Val Glu Gln Val  Asp Leu Asp 
    3005                 3010                 3015             


Val Val  Glu Thr Glu Val Gly  Met Glu Val Ser Val  Asp Gln Gln 
    3020                 3025                 3030             


Phe Ser  Pro Asp Leu Asn Asp  Asn Thr Ser Gln Ala  Tyr Arg Asp 
    3035                 3040                 3045             


Phe Asn  Lys Thr Phe Trp Asn  Gln Met Gln Lys Ile  Phe Ala Asp 
    3050                 3055                 3060             


Met Gln  Gly Phe Thr Phe Lys  Gly Val Glu Ile Leu  Ser Leu Arg 
    3065                 3070                 3075             


Asn Gly  Ser Ile Val Val Asp  Tyr Leu Val Leu Leu  Glu Met Pro 
    3080                 3085                 3090             


Phe Ser  Pro Gln Leu Glu Ser  Glu Tyr Glu Gln Val  Lys Thr Thr 
    3095                 3100                 3105             


Leu Lys  Glu Gly Leu Gln Asn  Ala Ser Gln Asp Val  Asn Ser Cys 
    3110                 3115                 3120             


Gln Asp  Ser Gln Thr Leu Cys  Phe Lys Pro Asp Ser  Ile Lys Val 
    3125                 3130                 3135             


Asn Asn  Asn Ser Lys Thr Glu  Leu Thr Pro Ala Ala  Ile Cys Arg 
    3140                 3145                 3150             


Arg Ala  Ala Pro Thr Gly Tyr  Glu Glu Phe Tyr Phe  Pro Leu Val 
    3155                 3160                 3165             


Glu Ala  Thr Arg Leu Arg Cys  Val Thr Lys Cys Thr  Ser Gly Val 
    3170                 3175                 3180             


Asp Asn  Ala Ile Asp Cys His  Gln Gly Gln Cys Val  Leu Glu Thr 
    3185                 3190                 3195             


Ser Gly  Pro Thr Cys Arg Ser  Trp Asp Gln Asp Arg  Lys Trp Phe 
    3200                 3205                 3210             


Glu Thr  Trp Asp Glu Glu Val  Val Gly Thr Phe Ser  Asn Trp Gly 
    3215                 3220                 3225             


Phe Glu  Asp Asp Gly Thr Asp  Lys Asp Thr Asn Phe  Tyr Val Ala 
    3230                 3235                 3240             


Leu Glu  Asn Val Asp Thr Thr  Met Lys Val His Ile  Lys Arg Pro 
    3245                 3250                 3255             


Glu Met  Thr Ser Ser Ser Val  
    3260                 3265 


<210>  9104
<211>  1002
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9104

Xaa Ile Thr Ile Thr Glu Ile Thr Ser His Ser Thr Leu Ser Tyr Thr 
1               5                   10                  15      


Thr Ser Ile Thr Thr Thr Glu Thr Pro Ser His Ser Thr Leu Ser Phe 
            20                  25                  30          


Thr Ser Ser Ile Thr Thr Thr Glu Thr Thr Ser His Ser Thr Pro Ser 
        35                  40                  45              


Phe Thr Ser Ser Ile Thr Thr Ser Glu Met Pro Ser His Ser Thr Pro 
    50                  55                  60                  


Ser Phe Thr Ser Ser Ile Thr Thr Thr Glu Asn Ala Thr His Ser Thr 
65                  70                  75                  80  


Pro Asn Phe Thr Ser Ser Ile Thr Thr Thr Glu Thr Thr Ser His Ser 
                85                  90                  95      


Thr Pro Ser Phe Thr Ser Leu Ile Thr Thr Thr Glu Thr Thr Ser His 
            100                 105                 110         


Arg Trp Gly Thr Thr Glu Thr Thr Ser Tyr Ser Thr Pro Ser Phe Thr 
        115                 120                 125             


Ser Ser Asn Thr Ile Thr Glu Thr Thr Ser His Ser Thr Pro Ser Tyr 
    130                 135                 140                 


Ile Thr Ser Ile Thr Thr Thr Glu Thr Pro Ser Ser Ser Thr Pro Ser 
145                 150                 155                 160 


Phe Ser Ser Ser Ile Thr Thr Thr Glu Thr Thr Ser His Ser Thr Pro 
                165                 170                 175     


Gly Phe Thr Ser Ser Ile Thr Thr Thr Glu Thr Thr Ser His Ser Thr 
            180                 185                 190         


Pro Ser Phe Thr Ser Ser Ile Thr Thr Thr Glu Thr Thr Ser His Asp 
        195                 200                 205             


Thr Pro Ser Phe Thr Ser Ser Ile Thr Thr Ser Glu Thr Pro Ser His 
    210                 215                 220                 


Ser Thr Pro Ser Ser Thr Ser Leu Ile Thr Thr Thr Lys Thr Thr Ser 
225                 230                 235                 240 


His Ser Thr Pro Ser Phe Thr Ser Ser Ile Thr Thr Thr Glu Thr Thr 
                245                 250                 255     


Ser His Ser Ala His Ser Phe Thr Ser Ser Ile Thr Thr Thr Glu Thr 
            260                 265                 270         


Thr Ser His Asn Thr Arg Ser Phe Thr Ser Ser Ile Thr Thr Thr Glu 
        275                 280                 285             


Thr Asn Ser His Ser Thr Thr Ser Phe Thr Ser Ser Ile Thr Thr Thr 
    290                 295                 300                 


Glu Thr Thr Ser His Ser Thr Pro Ser Phe Ser Ser Ser Ile Thr Thr 
305                 310                 315                 320 


Thr Glu Thr Pro Leu His Ser Thr Pro Gly Leu Thr Ser Trp Val Thr 
                325                 330                 335     


Thr Thr Lys Thr Thr Ser His Ile Thr Pro Gly Leu Thr Ser Ser Ile 
            340                 345                 350         


Thr Thr Thr Glu Thr Thr Ser His Ser Thr Pro Gly Phe Thr Ser Ser 
        355                 360                 365             


Ile Thr Thr Thr Glu Thr Thr Ser Glu Ser Thr Pro Ser Leu Ser Ser 
    370                 375                 380                 


Ser Thr Ile Tyr Ser Thr Val Ser Thr Ser Thr Thr Ala Ile Thr Ser 
385                 390                 395                 400 


His Phe Thr Thr Ser Glu Thr Ala Val Thr Pro Thr Pro Val Thr Pro 
                405                 410                 415     


Ser Ser Leu Ser Thr Asp Ile Pro Thr Thr Ser Leu Arg Thr Leu Thr 
            420                 425                 430         


Pro Ser Ser Val Gly Thr Ser Thr Ser Leu Thr Thr Thr Thr Asp Phe 
        435                 440                 445             


Pro Ser Ile Pro Thr Asp Ile Ser Thr Leu Pro Thr Arg Thr His Ile 
    450                 455                 460                 


Ile Ser Ser Ser Pro Ser Ile Gln Ser Thr Glu Thr Ser Ser Leu Val 
465                 470                 475                 480 


Gly Thr Thr Ser Pro Thr Met Ser Thr Val Arg Met Thr Leu Arg Ile 
                485                 490                 495     


Thr Glu Asn Thr Pro Ile Ser Ser Phe Ser Thr Ser Ile Val Val Ile 
            500                 505                 510         


Pro Glu Thr Pro Thr Gln Thr Pro Pro Val Leu Thr Ser Ala Thr Gly 
        515                 520                 525             


Thr Gln Thr Ser Pro Ala Pro Thr Thr Val Thr Phe Gly Ser Thr Asp 
    530                 535                 540                 


Ser Ser Thr Ser Thr Leu His Thr Leu Thr Pro Ser Thr Ala Leu Ser 
545                 550                 555                 560 


Thr Ile Val Ser Thr Ser Gln Val Pro Ile Pro Ser Thr His Ser Ser 
                565                 570                 575     


Thr Leu Gln Thr Thr Pro Ser Thr Pro Ser Leu Gln Thr Ser Leu Thr 
            580                 585                 590         


Ser Thr Ser Glu Phe Thr Thr Glu Ser Phe Thr Arg Gly Ser Thr Ser 
        595                 600                 605             


Thr Asn Ala Ile Leu Thr Ser Phe Ser Thr Ile Ile Trp Ser Ser Thr 
    610                 615                 620                 


Pro Thr Ile Ile Met Ser Ser Ser Pro Ser Ser Ala Ser Ile Thr Pro 
625                 630                 635                 640 


Val Phe Ser Thr Thr Ile His Ser Val Pro Ser Ser Pro Tyr Ile Phe 
                645                 650                 655     


Ser Thr Glu Asn Val Gly Ser Ala Ser Ile Thr Gly Phe Pro Ser Leu 
            660                 665                 670         


Ser Ser Ser Ala Thr Thr Ser Thr Ser Ser Thr Ser Ser Ser Leu Thr 
        675                 680                 685             


Thr Ala Leu Thr Glu Ile Thr Pro Phe Ser Tyr Ile Ser Leu Pro Ser 
    690                 695                 700                 


Thr Thr Pro Cys Pro Gly Thr Ile Thr Ile Thr Ile Val Pro Ala Ser 
705                 710                 715                 720 


Pro Thr Asp Pro Cys Val Glu Met Asp Pro Ser Thr Glu Ala Thr Ser 
                725                 730                 735     


Pro Pro Thr Thr Pro Leu Thr Val Phe Pro Phe Thr Thr Glu Met Val 
            740                 745                 750         


Thr Cys Pro Thr Ser Ile Ser Ile Gln Thr Thr Leu Thr Thr Tyr Met 
        755                 760                 765             


Asp Thr Ser Ser Met Met Pro Glu Ser Glu Ser Ser Ile Ser Pro Asn 
    770                 775                 780                 


Ala Ser Ser Ser Thr Gly Thr Gly Thr Val Pro Thr Asn Thr Val Phe 
785                 790                 795                 800 


Thr Ser Thr Arg Leu Pro Thr Ser Glu Thr Trp Leu Ser Asn Ser Ser 
                805                 810                 815     


Val Ile Pro Leu Pro Leu Pro Gly Val Ser Thr Ile Pro Leu Thr Met 
            820                 825                 830         


Lys Pro Ser Ser Ser Leu Pro Thr Ile Leu Arg Thr Ser Ser Lys Ser 
        835                 840                 845             


Thr His Pro Ser Pro Pro Thr Thr Arg Thr Ser Glu Thr Pro Val Ala 
    850                 855                 860                 


Thr Thr Gln Thr Pro Thr Thr Leu Thr Ser Arg Arg Thr Thr Arg Ile 
865                 870                 875                 880 


Thr Ser Gln Met Thr Thr Gln Ser Thr Leu Thr Thr Thr Ala Gly Thr 
                885                 890                 895     


Cys Asp Asn Gly Gly Thr Trp Glu Gln Gly Gln Cys Ala Cys Leu Pro 
            900                 905                 910         


Gly Phe Ser Gly Asp Arg Cys Gln Leu Gln Thr Arg Cys Gln Asn Gly 
        915                 920                 925             


Gly Gln Trp Asp Gly Leu Lys Cys Gln Cys Pro Ser Thr Phe Tyr Gly 
    930                 935                 940                 


Ser Ser Cys Glu Phe Ala Val Glu Gln Val Asp Leu Asp Ala Glu Asp 
945                 950                 955                 960 


Phe Cys Arg His Ala Gly Leu His Leu Gln Gly Cys Gly Asp Pro Val 
                965                 970                 975     


Pro Glu Glu Trp Gln His Arg Gly Gly Leu Pro Gly Pro Ala Gly Asp 
            980                 985                 990         


Ala Leu Gln Pro Pro Ala Gly Glu  Arg Val 
        995                 1000         


<210>  9105
<211>  5654
<212>  PRT
<213>  Homo Sapiens

<400>  9105

Met Ser Val Gly Arg Arg Lys Leu Ala Leu Leu Trp Ala Leu Ala Leu 
1               5                   10                  15      


Ala Leu Ala Cys Thr Arg His Thr Gly His Ala Gln Asp Gly Ser Ser 
            20                  25                  30          


Glu Ser Ser Tyr Lys His His Pro Ala Leu Ser Pro Ile Ala Arg Gly 
        35                  40                  45              


Pro Ser Gly Val Pro Leu Arg Gly Ala Thr Val Phe Pro Ser Leu Arg 
    50                  55                  60                  


Thr Ile Pro Val Val Arg Ala Ser Asn Pro Ala His Asn Gly Arg Val 
65                  70                  75                  80  


Cys Ser Thr Trp Gly Ser Phe His Tyr Lys Thr Phe Asp Gly Asp Val 
                85                  90                  95      


Phe Arg Phe Pro Gly Leu Cys Asn Tyr Val Phe Ser Glu His Cys Gly 
            100                 105                 110         


Ala Ala Tyr Glu Asp Phe Asn Ile Gln Leu Arg Arg Ser Gln Glu Ser 
        115                 120                 125             


Ala Ala Pro Thr Leu Ser Arg Val Leu Met Lys Val Asp Gly Val Val 
    130                 135                 140                 


Ile Gln Leu Thr Lys Gly Ser Val Leu Val Asn Gly His Pro Val Leu 
145                 150                 155                 160 


Leu Pro Phe Ser Gln Ser Gly Val Leu Ile Gln Gln Ser Ser Ser Tyr 
                165                 170                 175     


Thr Lys Val Glu Ala Arg Leu Gly Leu Val Leu Met Trp Asn His Asp 
            180                 185                 190         


Asp Ser Leu Leu Leu Glu Leu Asp Thr Lys Tyr Ala Asn Lys Thr Cys 
        195                 200                 205             


Gly Leu Cys Gly Asp Phe Asn Gly Met Pro Val Val Ser Glu Leu Leu 
    210                 215                 220                 


Ser His Asn Thr Lys Leu Thr Pro Met Glu Phe Gly Asn Leu Gln Lys 
225                 230                 235                 240 


Met Asp Asp Pro Thr Asp Gln Cys Gln Asp Pro Val Pro Glu Pro Pro 
                245                 250                 255     


Arg Asn Cys Ser Thr Gly Phe Gly Ile Cys Glu Glu Leu Leu His Gly 
            260                 265                 270         


Gln Leu Phe Ser Gly Cys Val Ala Leu Val Asp Val Gly Ser Tyr Leu 
        275                 280                 285             


Glu Ala Cys Arg Gln Asp Leu Cys Phe Cys Glu Asp Thr Asp Leu Leu 
    290                 295                 300                 


Ser Cys Val Cys His Thr Leu Ala Glu Tyr Ser Arg Gln Cys Thr His 
305                 310                 315                 320 


Ala Gly Gly Leu Pro Gln Asp Trp Arg Gly Pro Asp Phe Cys Pro Gln 
                325                 330                 335     


Lys Cys Pro Asn Asn Met Gln Tyr His Glu Cys Arg Ser Pro Cys Ala 
            340                 345                 350         


Asp Thr Cys Ser Asn Gln Glu His Ser Arg Ala Cys Glu Asp His Cys 
        355                 360                 365             


Val Ala Gly Cys Phe Cys Pro Glu Gly Thr Val Leu Asp Asp Ile Gly 
    370                 375                 380                 


Gln Thr Gly Cys Val Pro Val Ser Lys Cys Ala Cys Val Tyr Asn Gly 
385                 390                 395                 400 


Ala Ala Tyr Ala Pro Gly Ala Thr Tyr Ser Thr Asp Cys Thr Asn Cys 
                405                 410                 415     


Thr Cys Ser Gly Gly Arg Trp Ser Cys Gln Glu Val Pro Cys Pro Gly 
            420                 425                 430         


Thr Cys Ser Val Leu Gly Gly Ala His Phe Ser Thr Phe Asp Gly Lys 
        435                 440                 445             


Gln Tyr Thr Val His Gly Asp Cys Ser Tyr Val Leu Thr Lys Pro Cys 
    450                 455                 460                 


Asp Ser Ser Ala Phe Thr Val Leu Ala Glu Leu Arg Arg Cys Gly Leu 
465                 470                 475                 480 


Thr Asp Ser Glu Thr Cys Leu Lys Ser Val Thr Leu Ser Leu Asp Gly 
                485                 490                 495     


Ala Gln Thr Val Val Val Ile Lys Ala Ser Gly Glu Val Phe Leu Asn 
            500                 505                 510         


Gln Ile Tyr Thr Gln Leu Pro Ile Ser Ala Ala Asn Val Thr Ile Phe 
        515                 520                 525             


Arg Pro Ser Thr Phe Phe Ile Ile Ala Gln Thr Ser Leu Gly Leu Gln 
    530                 535                 540                 


Leu Asn Leu Gln Leu Val Pro Thr Met Gln Leu Phe Met Gln Leu Ala 
545                 550                 555                 560 


Pro Lys Leu Arg Gly Gln Thr Cys Gly Leu Cys Gly Asn Phe Asn Ser 
                565                 570                 575     


Ile Gln Ala Asp Asp Phe Arg Thr Leu Ser Gly Val Val Glu Ala Thr 
            580                 585                 590         


Ala Ala Ala Phe Phe Asn Thr Phe Lys Thr Gln Ala Ala Cys Pro Asn 
        595                 600                 605             


Ile Arg Asn Ser Phe Glu Asp Pro Cys Ser Leu Ser Val Glu Asn Glu 
    610                 615                 620                 


Lys Tyr Ala Gln His Trp Cys Ser Gln Leu Thr Asp Ala Asp Gly Pro 
625                 630                 635                 640 


Phe Gly Arg Cys His Ala Ala Val Lys Pro Gly Thr Tyr Tyr Ser Asn 
                645                 650                 655     


Cys Met Phe Asp Thr Cys Asn Cys Glu Arg Ser Glu Asp Cys Leu Cys 
            660                 665                 670         


Ala Ala Leu Ser Ser Tyr Val His Ala Cys Ala Ala Lys Gly Val Gln 
        675                 680                 685             


Leu Gly Gly Trp Arg Asp Gly Val Cys Thr Lys Pro Met Thr Thr Cys 
    690                 695                 700                 


Pro Lys Ser Met Thr Tyr His Tyr His Val Ser Thr Cys Gln Pro Thr 
705                 710                 715                 720 


Cys Arg Ser Leu Ser Glu Gly Asp Ile Thr Cys Ser Val Gly Phe Ile 
                725                 730                 735     


Pro Val Asp Gly Cys Ile Cys Pro Lys Gly Thr Phe Leu Asp Asp Thr 
            740                 745                 750         


Gly Lys Cys Val Gln Ala Ser Asn Cys Pro Cys Tyr His Arg Gly Ser 
        755                 760                 765             


Met Ile Pro Asn Gly Glu Ser Val His Asp Ser Gly Ala Ile Cys Thr 
    770                 775                 780                 


Cys Thr His Gly Lys Leu Ser Cys Ile Gly Gly Gln Ala Pro Ala Pro 
785                 790                 795                 800 


Val Cys Ala Ala Pro Met Val Phe Phe Asp Cys Arg Asn Ala Thr Pro 
                805                 810                 815     


Gly Asp Thr Gly Ala Gly Cys Gln Lys Ser Cys His Thr Leu Asp Met 
            820                 825                 830         


Thr Cys Tyr Ser Pro Gln Cys Val Pro Gly Cys Val Cys Pro Asp Gly 
        835                 840                 845             


Leu Val Ala Asp Gly Glu Gly Gly Cys Ile Thr Ala Glu Asp Cys Pro 
    850                 855                 860                 


Cys Val His Asn Glu Ala Ser Tyr Arg Ala Gly Gln Thr Ile Arg Val 
865                 870                 875                 880 


Gly Cys Asn Thr Cys Thr Cys Asp Ser Arg Met Trp Arg Cys Thr Asp 
                885                 890                 895     


Asp Pro Cys Leu Ala Thr Cys Ala Val Tyr Gly Asp Gly His Tyr Leu 
            900                 905                 910         


Thr Phe Asp Gly Gln Ser Tyr Ser Phe Asn Gly Asp Cys Glu Tyr Thr 
        915                 920                 925             


Leu Val Gln Asn His Cys Gly Gly Lys Asp Ser Thr Gln Asp Ser Phe 
    930                 935                 940                 


Arg Val Val Thr Glu Asn Val Pro Cys Gly Thr Thr Gly Thr Thr Cys 
945                 950                 955                 960 


Ser Lys Ala Ile Lys Ile Phe Leu Gly Gly Phe Glu Leu Lys Leu Ser 
                965                 970                 975     


His Gly Lys Val Glu Val Ile Gly Thr Asp Glu Ser Gln Glu Val Pro 
            980                 985                 990         


Tyr Thr Ile Arg Gln Met Gly Ile  Tyr Leu Val Val Asp  Thr Asp Ile 
        995                 1000                 1005             


Gly Leu  Val Leu Leu Trp Asp  Lys Lys Thr Ser Ile  Phe Ile Asn 
    1010                 1015                 1020             


Leu Ser  Pro Glu Phe Lys Gly  Arg Val Cys Gly Leu  Cys Gly Asn 
    1025                 1030                 1035             


Phe Asp  Asp Ile Ala Val Asn  Asp Phe Ala Thr Arg  Ser Arg Ser 
    1040                 1045                 1050             


Val Val  Gly Asp Val Leu Glu  Phe Gly Asn Ser Trp  Lys Leu Ser 
    1055                 1060                 1065             


Pro Ser  Cys Pro Asp Ala Leu  Ala Pro Lys Asp Pro  Cys Thr Ala 
    1070                 1075                 1080             


Asn Pro  Phe Arg Lys Ser Trp  Ala Gln Lys Gln Cys  Ser Ile Leu 
    1085                 1090                 1095             


His Gly  Pro Thr Phe Ala Ala  Cys His Ala His Val  Glu Pro Ala 
    1100                 1105                 1110             


Arg Tyr  Tyr Glu Ala Cys Val  Asn Asp Ala Cys Ala  Cys Asp Ser 
    1115                 1120                 1125             


Gly Gly  Asp Cys Glu Cys Phe  Cys Thr Ala Val Ala  Ala Tyr Ala 
    1130                 1135                 1140             


Gln Ala  Cys His Glu Val Gly  Leu Cys Val Ser Trp  Arg Thr Pro 
    1145                 1150                 1155             


Ser Ile  Cys Pro Leu Phe Cys  Asp Tyr Tyr Asn Pro  Glu Gly Gln 
    1160                 1165                 1170             


Cys Glu  Trp His Tyr Gln Pro  Cys Gly Val Pro Cys  Leu Arg Thr 
    1175                 1180                 1185             


Cys Arg  Asn Pro Arg Gly Asp  Cys Leu Arg Asp Val  Arg Gly Leu 
    1190                 1195                 1200             


Glu Gly  Cys Tyr Pro Lys Cys  Pro Pro Glu Ala Pro  Ile Phe Asp 
    1205                 1210                 1215             


Glu Asp  Lys Met Gln Cys Val  Ala Thr Cys Pro Thr  Pro Pro Leu 
    1220                 1225                 1230             


Pro Pro  Arg Cys His Val His  Gly Lys Ser Tyr Arg  Pro Gly Ala 
    1235                 1240                 1245             


Val Val  Pro Ser Asp Lys Asn  Cys Gln Ser Cys Leu  Cys Thr Glu 
    1250                 1255                 1260             


Arg Gly  Val Glu Cys Thr Tyr  Lys Ala Glu Ala Cys  Val Cys Thr 
    1265                 1270                 1275             


Tyr Asn  Gly Gln Arg Phe His  Pro Gly Asp Val Ile  Tyr His Thr 
    1280                 1285                 1290             


Thr Asp  Gly Thr Gly Gly Cys  Ile Ser Ala Arg Cys  Gly Ala Asn 
    1295                 1300                 1305             


Gly Thr  Ile Glu Arg Arg Val  Tyr Pro Cys Ser Pro  Thr Thr Pro 
    1310                 1315                 1320             


Val Pro  Pro Thr Thr Phe Ser  Phe Ser Thr Pro Pro  Leu Val Val 
    1325                 1330                 1335             


Ser Ser  Thr His Thr Pro Ser  Asn Gly Pro Ser Ser  Ala His Thr 
    1340                 1345                 1350             


Gly Pro  Pro Ser Ser Ala Trp  Pro Thr Thr Ala Gly  Thr Ser Pro 
    1355                 1360                 1365             


Arg Thr  Arg Leu Pro Thr Ala  Ser Ala Ser Leu Pro  Pro Val Cys 
    1370                 1375                 1380             


Gly Glu  Lys Cys Leu Trp Ser  Pro Trp Met Asp Val  Ser Arg Pro 
    1385                 1390                 1395             


Gly Arg  Gly Thr Asp Ser Gly  Asp Phe Asp Thr Leu  Glu Asn Leu 
    1400                 1405                 1410             


Arg Ala  His Gly Tyr Arg Val  Cys Glu Ser Pro Arg  Ser Val Glu 
    1415                 1420                 1425             


Cys Arg  Ala Glu Asp Ala Pro  Gly Val Pro Leu Arg  Ala Leu Gly 
    1430                 1435                 1440             


Gln Arg  Val Gln Cys Ser Pro  Asp Val Gly Leu Thr  Cys Arg Asn 
    1445                 1450                 1455             


Arg Glu  Gln Ala Ser Gly Leu  Cys Tyr Asn Tyr Gln  Ile Arg Val 
    1460                 1465                 1470             


Gln Cys  Cys Thr Pro Leu Pro  Cys Ser Thr Ser Ser  Ser Pro Ala 
    1475                 1480                 1485             


Gln Thr  Thr Pro Pro Thr Thr  Ser Lys Thr Thr Glu  Thr Arg Ala 
    1490                 1495                 1500             


Ser Gly  Ser Ser Ala Pro Ser  Ser Thr Pro Gly Thr  Val Ser Leu 
    1505                 1510                 1515             


Ser Thr  Ala Arg Thr Thr Pro  Ala Pro Gly Thr Ala  Thr Ser Val 
    1520                 1525                 1530             


Lys Lys  Thr Phe Ser Thr Pro  Ser Pro Pro Pro Val  Pro Ala Thr 
    1535                 1540                 1545             


Ser Thr  Ser Ser Met Ser Thr  Thr Ala Pro Gly Thr  Ser Val Val 
    1550                 1555                 1560             


Ser Ser  Lys Pro Thr Pro Thr  Glu Pro Ser Thr Ser  Ser Cys Leu 
    1565                 1570                 1575             


Gln Glu  Leu Cys Thr Trp Thr  Glu Trp Ile Asp Gly  Ser Tyr Pro 
    1580                 1585                 1590             


Ala Pro  Gly Ile Asn Gly Gly  Asp Phe Asp Thr Phe  Gln Asn Leu 
    1595                 1600                 1605             


Arg Asp  Glu Gly Tyr Thr Phe  Cys Glu Ser Pro Arg  Ser Val Gln 
    1610                 1615                 1620             


Cys Arg  Ala Glu Ser Phe Pro  Asn Thr Pro Leu Ala  Asp Leu Gly 
    1625                 1630                 1635             


Gln Asp  Val Ile Cys Ser His  Thr Glu Gly Leu Ile  Cys Leu Asn 
    1640                 1645                 1650             


Lys Asn  Gln Leu Pro Pro Ile  Cys Tyr Asn Tyr Glu  Ile Arg Ile 
    1655                 1660                 1665             


Gln Cys  Cys Glu Thr Val Asn  Val Cys Arg Asp Ile  Thr Arg Leu 
    1670                 1675                 1680             


Pro Lys  Thr Val Ala Thr Thr  Arg Pro Thr Pro His  Pro Thr Gly 
    1685                 1690                 1695             


Ala Gln  Thr Gln Thr Thr Phe  Thr Thr His Met Pro  Ser Ala Ser 
    1700                 1705                 1710             


Thr Glu  Gln Pro Thr Ala Thr  Ser Arg Gly Gly Pro  Thr Ala Thr 
    1715                 1720                 1725             


Ser Val  Thr Gln Gly Thr His  Thr Thr Leu Val Thr  Arg Asn Cys 
    1730                 1735                 1740             


His Pro  Arg Cys Thr Trp Thr  Lys Trp Phe Asp Val  Asp Phe Pro 
    1745                 1750                 1755             


Ser Pro  Gly Pro His Gly Gly  Asp Lys Glu Thr Tyr  Asn Asn Ile 
    1760                 1765                 1770             


Ile Arg  Ser Gly Glu Lys Ile  Cys Arg Arg Pro Glu  Glu Ile Thr 
    1775                 1780                 1785             


Arg Leu  Gln Cys Arg Ala Lys  Ser His Pro Glu Val  Ser Ile Glu 
    1790                 1795                 1800             


His Leu  Gly Gln Val Val Gln  Cys Ser Arg Glu Glu  Gly Leu Val 
    1805                 1810                 1815             


Cys Arg  Asn Gln Asp Gln Gln  Gly Pro Phe Lys Met  Cys Leu Asn 
    1820                 1825                 1830             


Tyr Glu  Val Arg Val Leu Cys  Cys Glu Thr Pro Arg  Gly Cys His 
    1835                 1840                 1845             


Met Thr  Ser Thr Pro Gly Ser  Thr Ser Ser Ser Pro  Ala Gln Thr 
    1850                 1855                 1860             


Thr Pro  Ser Thr Thr Ser Lys  Thr Thr Glu Thr Gln  Ala Ser Gly 
    1865                 1870                 1875             


Ser Ser  Ala Pro Ser Ser Thr  Pro Gly Thr Val Ser  Leu Ser Thr 
    1880                 1885                 1890             


Ala Arg  Thr Thr Pro Ala Pro  Gly Thr Ala Thr Ser  Val Lys Lys 
    1895                 1900                 1905             


Thr Phe  Ser Thr Pro Ser Pro  Pro Pro Val Pro Ala  Thr Ser Thr 
    1910                 1915                 1920             


Ser Ser  Met Ser Thr Thr Ala  Pro Gly Thr Ser Val  Val Ser Ser 
    1925                 1930                 1935             


Lys Pro  Thr Pro Thr Glu Pro  Ser Thr Ser Ser Cys  Leu Gln Glu 
    1940                 1945                 1950             


Leu Cys  Thr Trp Thr Glu Trp  Ile Asp Gly Ser Tyr  Pro Ala Pro 
    1955                 1960                 1965             


Gly Ile  Asn Gly Gly Asp Phe  Asp Thr Phe Gln Asn  Leu Arg Asp 
    1970                 1975                 1980             


Glu Gly  Tyr Thr Phe Cys Glu  Ser Pro Arg Ser Val  Gln Cys Arg 
    1985                 1990                 1995             


Ala Glu  Ser Phe Pro Asn Thr  Pro Leu Ala Asp Leu  Gly Gln Asp 
    2000                 2005                 2010             


Val Ile  Cys Ser His Thr Glu  Gly Leu Ile Cys Leu  Asn Lys Asn 
    2015                 2020                 2025             


Gln Leu  Pro Pro Ile Cys Tyr  Asn Tyr Glu Ile Arg  Ile Gln Cys 
    2030                 2035                 2040             


Cys Glu  Thr Val Asn Val Cys  Arg Asp Ile Thr Arg  Pro Pro Lys 
    2045                 2050                 2055             


Thr Val  Ala Thr Thr Arg Pro  Thr Pro His Pro Thr  Gly Ala Gln 
    2060                 2065                 2070             


Thr Gln  Thr Thr Phe Thr Thr  His Met Pro Ser Ala  Ser Thr Glu 
    2075                 2080                 2085             


Gln Pro  Thr Ala Thr Ser Arg  Gly Gly Pro Thr Ala  Thr Ser Val 
    2090                 2095                 2100             


Thr Gln  Gly Thr His Thr Thr  Pro Val Thr Arg Asn  Cys His Pro 
    2105                 2110                 2115             


Arg Cys  Thr Trp Thr Thr Trp  Phe Asp Val Asp Phe  Pro Ser Pro 
    2120                 2125                 2130             


Gly Pro  His Gly Gly Asp Lys  Glu Thr Tyr Asn Asn  Ile Ile Arg 
    2135                 2140                 2145             


Ser Gly  Glu Lys Ile Cys Arg  Arg Pro Glu Glu Ile  Thr Arg Leu 
    2150                 2155                 2160             


Gln Cys  Arg Ala Lys Ser His  Pro Glu Val Ser Ile  Glu His Leu 
    2165                 2170                 2175             


Gly Gln  Val Val Gln Cys Ser  Arg Glu Glu Gly Leu  Val Cys Arg 
    2180                 2185                 2190             


Asn Gln  Asp Gln Gln Gly Pro  Phe Lys Met Cys Leu  Asn Tyr Glu 
    2195                 2200                 2205             


Val Arg  Val Leu Cys Cys Glu  Thr Pro Lys Gly Cys  Pro Val Thr 
    2210                 2215                 2220             


Ser Thr  Pro Val Thr Ala Pro  Ser Thr Pro Ser Gly  Arg Ala Thr 
    2225                 2230                 2235             


Ser Pro  Thr Gln Ser Thr Ser  Ser Trp Gln Lys Ser  Arg Thr Thr 
    2240                 2245                 2250             


Thr Leu  Val Thr Thr Ser Thr  Thr Ser Thr Pro Gln  Thr Ser Thr 
    2255                 2260                 2265             


Thr Tyr  Ala His Thr Thr Ser  Thr Thr Ser Ala Pro  Thr Ala Arg 
    2270                 2275                 2280             


Thr Thr  Ser Ala Pro Thr Thr  Arg Thr Thr Ser Ala  Ser Pro Ala 
    2285                 2290                 2295             


Ser Thr  Thr Ser Gly Pro Gly  Asn Thr Pro Ser Pro  Val Pro Thr 
    2300                 2305                 2310             


Thr Ser  Thr Ile Ser Ala Pro  Thr Thr Ser Ile Thr  Ser Ala Pro 
    2315                 2320                 2325             


Thr Thr  Ser Thr Thr Ser Ala  Pro Thr Ser Ser Thr  Thr Ser Gly 
    2330                 2335                 2340             


Pro Gly  Thr Thr Pro Ser Pro  Val Pro Thr Thr Ser  Ile Thr Ser 
    2345                 2350                 2355             


Ala Pro  Thr Thr Ser Thr Thr  Ser Ala Pro Thr Thr  Ser Thr Thr 
    2360                 2365                 2370             


Ser Ala  Arg Thr Ser Ser Thr  Thr Ser Ala Thr Thr  Thr Ser Arg 
    2375                 2380                 2385             


Ile Ser  Gly Pro Glu Thr Thr  Pro Ser Pro Val Pro  Thr Thr Ser 
    2390                 2395                 2400             


Thr Thr  Ser Ala Thr Thr Thr  Ser Thr Thr Ser Ala  Pro Thr Thr 
    2405                 2410                 2415             


Ser Thr  Thr Ser Ala Pro Thr  Ser Ser Thr Thr Ser  Ser Pro Gln 
    2420                 2425                 2430             


Thr Ser  Thr Thr Ser Ala Pro  Thr Thr Ser Thr Thr  Ser Gly Pro 
    2435                 2440                 2445             


Gly Thr  Thr Pro Ser Pro Val  Pro Thr Thr Ser Thr  Thr Ser Ala 
    2450                 2455                 2460             


Pro Thr  Thr Arg Thr Thr Ser  Ala Pro Lys Ser Ser  Thr Thr Ser 
    2465                 2470                 2475             


Ala Ala  Thr Thr Ser Thr Thr  Ser Gly Pro Glu Thr  Thr Pro Arg 
    2480                 2485                 2490             


Pro Val  Pro Thr Thr Ser Thr  Thr Ser Ser Pro Thr  Thr Ser Thr 
    2495                 2500                 2505             


Thr Ser  Ala Pro Thr Thr Ser  Thr Thr Ser Ala Ser  Thr Thr Ser 
    2510                 2515                 2520             


Thr Thr  Ser Gly Ala Gly Thr  Thr Pro Ser Pro Val  Pro Thr Thr 
    2525                 2530                 2535             


Ser Thr  Thr Ser Ala Pro Thr  Thr Ser Thr Thr Ser  Ala Pro Ile 
    2540                 2545                 2550             


Ser Ser  Thr Thr Ser Ala Thr  Thr Thr Ser Thr Thr  Ser Gly Pro 
    2555                 2560                 2565             


Gly Thr  Thr Pro Ser Pro Val  Pro Thr Thr Ser Thr  Thr Ser Ala 
    2570                 2575                 2580             


Pro Thr  Thr Ser Thr Thr Ser  Gly Pro Gly Thr Thr  Pro Ser Ala 
    2585                 2590                 2595             


Val Pro  Thr Thr Ser Ile Thr  Ser Ala Pro Thr Thr  Ser Thr Asn 
    2600                 2605                 2610             


Ser Ala  Pro Ile Ser Ser Thr  Thr Ser Ala Thr Thr  Thr Ser Arg 
    2615                 2620                 2625             


Ile Ser  Gly Pro Glu Thr Thr  Pro Ser Pro Val Pro  Thr Ala Ser 
    2630                 2635                 2640             


Thr Thr  Ser Ala Ser Thr Thr  Ser Thr Thr Ser Gly  Pro Gly Thr 
    2645                 2650                 2655             


Thr Pro  Ser Pro Val Pro Thr  Thr Ser Thr Ile Ser  Val Pro Thr 
    2660                 2665                 2670             


Thr Ser  Thr Thr Ser Ala Ser  Thr Thr Ser Thr Thr  Ser Ala Ser 
    2675                 2680                 2685             


Thr Thr  Ser Thr Thr Ser Gly  Pro Gly Thr Thr Pro  Ser Pro Val 
    2690                 2695                 2700             


Pro Thr  Thr Ser Thr Thr Ser  Ala Pro Thr Thr Ser  Thr Thr Ser 
    2705                 2710                 2715             


Ala Pro  Thr Thr Ser Thr Ile  Ser Ala Pro Thr Thr  Ser Thr Thr 
    2720                 2725                 2730             


Ser Ala  Thr Thr Thr Ser Thr  Thr Ser Ala Pro Thr  Pro Arg Arg 
    2735                 2740                 2745             


Thr Ser  Ala Pro Thr Thr Ser  Thr Ile Ser Ala Ser  Thr Thr Ser 
    2750                 2755                 2760             


Thr Thr  Ser Ala Thr Thr Thr  Ser Thr Thr Ser Ala  Thr Thr Thr 
    2765                 2770                 2775             


Ser Thr  Ile Ser Ala Pro Thr  Thr Ser Thr Thr Leu  Ser Pro Thr 
    2780                 2785                 2790             


Thr Ser  Thr Thr Ser Thr Thr  Ile Thr Ser Thr Thr  Ser Ala Pro 
    2795                 2800                 2805             


Ile Ser  Ser Thr Thr Ser Thr  Pro Gln Thr Ser Thr  Thr Ser Ala 
    2810                 2815                 2820             


Pro Thr  Thr Ser Thr Thr Ser  Gly Pro Gly Thr Thr  Ser Ser Pro 
    2825                 2830                 2835             


Val Pro  Thr Thr Ser Thr Thr  Ser Ala Pro Thr Thr  Ser Thr Thr 
    2840                 2845                 2850             


Ser Ala  Pro Thr Thr Arg Thr  Thr Ser Val Pro Thr  Ser Ser Thr 
    2855                 2860                 2865             


Thr Ser  Thr Ala Thr Thr Ser  Thr Thr Ser Gly Pro  Gly Thr Thr 
    2870                 2875                 2880             


Pro Ser  Pro Val Pro Thr Thr  Ser Thr Thr Ser Ala  Pro Thr Thr 
    2885                 2890                 2895             


Arg Thr  Thr Ser Ala Pro Thr  Thr Ser Thr Thr Ser  Ala Pro Thr 
    2900                 2905                 2910             


Thr Ser  Thr Thr Ser Ala Pro  Thr Ser Ser Thr Thr  Ser Ala Thr 
    2915                 2920                 2925             


Thr Thr  Ser Thr Ile Ser Val  Pro Thr Thr Ser Thr  Thr Ser Val 
    2930                 2935                 2940             


Pro Gly  Thr Thr Pro Ser Pro  Val Pro Thr Thr Ser  Thr Ile Ser 
    2945                 2950                 2955             


Val Pro  Thr Thr Ser Thr Thr  Ser Ala Ser Thr Thr  Ser Thr Thr 
    2960                 2965                 2970             


Ser Gly  Pro Gly Thr Thr Pro  Ser Pro Val Pro Thr  Thr Ser Thr 
    2975                 2980                 2985             


Thr Ser  Ala Pro Thr Thr Ser  Thr Thr Ser Ala Pro  Thr Thr Ser 
    2990                 2995                 3000             


Thr Ile  Ser Ala Pro Thr Thr  Ser Thr Pro Ser Ala  Pro Thr Thr 
    3005                 3010                 3015             


Ser Thr  Thr Leu Ala Pro Thr  Thr Ser Thr Thr Ser  Ala Pro Thr 
    3020                 3025                 3030             


Thr Ser  Thr Thr Ser Thr Pro  Thr Ser Ser Thr Thr  Ser Ser Pro 
    3035                 3040                 3045             


Gln Thr  Ser Thr Thr Ser Ala  Ser Thr Thr Ser Ile  Thr Ser Gly 
    3050                 3055                 3060             


Pro Gly  Thr Thr Pro Ser Pro  Val Pro Thr Thr Ser  Thr Thr Ser 
    3065                 3070                 3075             


Ala Pro  Thr Thr Ser Thr Thr  Ser Ala Ala Thr Thr  Ser Thr Ile 
    3080                 3085                 3090             


Ser Ala  Pro Thr Thr Ser Thr  Thr Ser Ala Pro Thr  Thr Ser Thr 
    3095                 3100                 3105             


Thr Ser  Ala Ser Thr Ala Ser  Lys Thr Ser Gly Leu  Gly Thr Thr 
    3110                 3115                 3120             


Pro Ser  Pro Ile Pro Thr Thr  Ser Thr Thr Ser Pro  Pro Thr Thr 
    3125                 3130                 3135             


Ser Thr  Thr Ser Ala Ser Thr  Ala Ser Lys Thr Ser  Gly Pro Gly 
    3140                 3145                 3150             


Thr Thr  Pro Ser Pro Val Pro  Thr Thr Ser Thr Ile  Phe Ala Pro 
    3155                 3160                 3165             


Arg Thr  Ser Thr Thr Ser Ala  Ser Thr Thr Ser Thr  Thr Pro Gly 
    3170                 3175                 3180             


Pro Gly  Thr Thr Pro Ser Pro  Val Pro Thr Thr Ser  Thr Ala Ser 
    3185                 3190                 3195             


Val Ser  Lys Thr Ser Thr Ser  His Val Ser Ile Ser  Lys Thr Thr 
    3200                 3205                 3210             


His Ser  Gln Pro Val Thr Arg  Asp Cys His Leu Arg  Cys Thr Trp 
    3215                 3220                 3225             


Thr Lys  Trp Phe Asp Ile Asp  Phe Pro Ser Pro Gly  Pro His Gly 
    3230                 3235                 3240             


Gly Asp  Lys Glu Thr Tyr Asn  Asn Ile Ile Arg Ser  Gly Glu Lys 
    3245                 3250                 3255             


Ile Cys  Arg Arg Pro Glu Glu  Ile Thr Arg Leu Gln  Cys Arg Ala 
    3260                 3265                 3270             


Glu Ser  His Pro Glu Val Ser  Ile Glu His Leu Gly  Gln Val Val 
    3275                 3280                 3285             


Gln Cys  Ser Arg Glu Glu Gly  Leu Val Cys Arg Asn  Gln Asp Gln 
    3290                 3295                 3300             


Gln Gly  Pro Phe Lys Met Cys  Leu Asn Tyr Glu Val  Arg Val Leu 
    3305                 3310                 3315             


Cys Cys  Glu Thr Pro Lys Gly  Cys Pro Val Thr Ser  Thr Pro Val 
    3320                 3325                 3330             


Thr Ala  Pro Ser Thr Pro Ser  Gly Arg Ala Thr Ser  Pro Thr Gln 
    3335                 3340                 3345             


Ser Thr  Ser Ser Trp Gln Lys  Ser Arg Thr Thr Thr  Leu Val Thr 
    3350                 3355                 3360             


Thr Ser  Thr Thr Ser Thr Pro  Gln Thr Ser Thr Thr  Ser Ala Pro 
    3365                 3370                 3375             


Thr Thr  Ser Thr Thr Ser Ala  Pro Thr Thr Ser Thr  Thr Ser Ala 
    3380                 3385                 3390             


Pro Thr  Thr Ser Thr Thr Ser  Thr Pro Gln Thr Ser  Ile Ser Ser 
    3395                 3400                 3405             


Ala Pro  Thr Ser Ser Thr Thr  Ser Ala Pro Thr Ser  Ser Thr Ile 
    3410                 3415                 3420             


Ser Ala  Arg Thr Thr Ser Ile  Ile Ser Ala Pro Thr  Thr Ser Thr 
    3425                 3430                 3435             


Thr Ser  Ser Pro Thr Thr Ser  Thr Thr Ser Ala Thr  Thr Thr Ser 
    3440                 3445                 3450             


Thr Thr  Ser Ala Pro Thr Ser  Ser Thr Thr Ser Thr  Pro Gln Thr 
    3455                 3460                 3465             


Ser Lys  Thr Ser Ala Ala Thr  Ser Ser Thr Thr Ser  Gly Ser Gly 
    3470                 3475                 3480             


Thr Thr  Pro Ser Pro Val Thr  Thr Thr Ser Thr Ala  Ser Val Ser 
    3485                 3490                 3495             


Lys Thr  Ser Thr Ser His Val  Ser Val Ser Lys Thr  Thr His Ser 
    3500                 3505                 3510             


Gln Pro  Val Thr Arg Asp Cys  His Pro Arg Cys Thr  Trp Thr Lys 
    3515                 3520                 3525             


Trp Phe  Asp Val Asp Phe Pro  Ser Pro Gly Pro His  Gly Gly Asp 
    3530                 3535                 3540             


Lys Glu  Thr Tyr Asn Asn Ile  Ile Arg Ser Gly Glu  Lys Ile Cys 
    3545                 3550                 3555             


Arg Arg  Pro Glu Glu Ile Thr  Arg Leu Gln Cys Arg  Ala Lys Ser 
    3560                 3565                 3570             


His Pro  Glu Val Ser Ile Glu  His Leu Gly Gln Val  Val Gln Cys 
    3575                 3580                 3585             


Ser Arg  Glu Glu Gly Leu Val  Cys Arg Asn Gln Asp  Gln Gln Gly 
    3590                 3595                 3600             


Pro Phe  Lys Met Cys Leu Asn  Tyr Glu Val Arg Val  Leu Cys Cys 
    3605                 3610                 3615             


Glu Thr  Pro Lys Gly Cys Pro  Val Thr Ser Thr Ser  Val Thr Ala 
    3620                 3625                 3630             


Pro Ser  Thr Pro Ser Gly Arg  Ala Thr Ser Pro Thr  Gln Ser Thr 
    3635                 3640                 3645             


Ser Ser  Trp Gln Lys Ser Arg  Thr Thr Thr Leu Val  Thr Ser Ser 
    3650                 3655                 3660             


Ile Thr  Ser Thr Thr Gln Thr  Ser Thr Thr Ser Ala  Pro Thr Thr 
    3665                 3670                 3675             


Ser Thr  Thr Pro Ala Ser Ile  Pro Ser Thr Thr Ser  Ala Pro Thr 
    3680                 3685                 3690             


Thr Ser  Thr Thr Ser Ala Pro  Thr Thr Ser Thr Thr  Ser Ala Pro 
    3695                 3700                 3705             


Thr Thr  Ser Thr Thr Ser Thr  Pro Gln Thr Thr Thr  Ser Ser Ala 
    3710                 3715                 3720             


Pro Thr  Ser Ser Thr Thr Ser  Ala Pro Thr Thr Ser  Thr Ile Ser 
    3725                 3730                 3735             


Ala Pro  Thr Thr Ser Thr Ile  Ser Ala Pro Thr Thr  Ser Thr Thr 
    3740                 3745                 3750             


Ser Ala  Pro Thr Ala Ser Thr  Thr Ser Ala Pro Thr  Ser Thr Ser 
    3755                 3760                 3765             


Ser Ala  Pro Thr Thr Asn Thr  Thr Ser Ala Pro Thr  Thr Ser Thr 
    3770                 3775                 3780             


Thr Ser  Ala Pro Ile Thr Ser  Thr Ile Ser Ala Pro  Thr Thr Ser 
    3785                 3790                 3795             


Thr Thr  Ser Thr Pro Gln Thr  Ser Thr Ile Ser Ser  Pro Thr Thr 
    3800                 3805                 3810             


Ser Thr  Thr Ser Thr Pro Gln  Thr Ser Thr Thr Ser  Ser Pro Thr 
    3815                 3820                 3825             


Thr Ser  Thr Thr Ser Ala Pro  Thr Thr Ser Thr Thr  Ser Ala Pro 
    3830                 3835                 3840             


Thr Thr  Ser Thr Thr Ser Thr  Pro Gln Thr Ser Ile  Ser Ser Ala 
    3845                 3850                 3855             


Pro Thr  Ser Ser Thr Thr Ser  Ala Pro Thr Ala Ser  Thr Ile Ser 
    3860                 3865                 3870             


Ala Pro  Thr Thr Ser Thr Thr  Ser Phe His Thr Thr  Ser Thr Thr 
    3875                 3880                 3885             


Ser Pro  Pro Thr Ser Ser Thr  Ser Ser Thr Pro Gln  Thr Ser Lys 
    3890                 3895                 3900             


Thr Ser  Ala Ala Thr Ser Ser  Thr Thr Ser Gly Ser  Gly Thr Thr 
    3905                 3910                 3915             


Pro Ser  Pro Val Pro Thr Thr  Ser Thr Ala Ser Val  Ser Lys Thr 
    3920                 3925                 3930             


Ser Thr  Ser His Val Ser Val  Ser Lys Thr Thr His  Ser Gln Pro 
    3935                 3940                 3945             


Val Thr  Arg Asp Cys His Pro  Arg Cys Thr Trp Thr  Lys Trp Phe 
    3950                 3955                 3960             


Asp Val  Asp Phe Pro Ser Pro  Gly Pro His Gly Gly  Asp Lys Glu 
    3965                 3970                 3975             


Thr Tyr  Asn Asn Ile Ile Arg  Ser Gly Glu Lys Ile  Cys Arg Arg 
    3980                 3985                 3990             


Pro Glu  Glu Ile Thr Arg Leu  Gln Cys Arg Ala Glu  Ser His Pro 
    3995                 4000                 4005             


Glu Val  Ser Ile Glu His Leu  Gly Gln Val Val Gln  Cys Ser Arg 
    4010                 4015                 4020             


Glu Glu  Gly Leu Val Cys Arg  Asn Gln Asp Gln Gln  Gly Pro Phe 
    4025                 4030                 4035             


Lys Met  Cys Leu Asn Tyr Glu  Val Arg Val Leu Cys  Cys Glu Thr 
    4040                 4045                 4050             


Pro Lys  Gly Cys Pro Val Thr  Ser Thr Pro Val Thr  Ala Pro Ser 
    4055                 4060                 4065             


Thr Pro  Ser Gly Arg Ala Thr  Ser Pro Thr Gln Ser  Thr Ser Ser 
    4070                 4075                 4080             


Trp Gln  Lys Ser Arg Thr Thr  Thr Leu Val Thr Thr  Ser Thr Thr 
    4085                 4090                 4095             


Ser Thr  Pro Gln Thr Ser Thr  Thr Ser Ala Pro Thr  Thr Ser Thr 
    4100                 4105                 4110             


Ile Pro  Ala Ser Thr Pro Ser  Thr Thr Ser Ala Pro  Thr Thr Ser 
    4115                 4120                 4125             


Thr Thr  Ser Ala Pro Thr Thr  Ser Thr Thr Ser Ala  Pro Thr His 
    4130                 4135                 4140             


Arg Thr  Thr Ser Gly Pro Thr  Thr Ser Thr Thr Leu  Ala Pro Thr 
    4145                 4150                 4155             


Thr Ser  Thr Thr Ser Ala Pro  Thr Thr Ser Thr Asn  Ser Ala Pro 
    4160                 4165                 4170             


Thr Thr  Ser Thr Ile Ser Ala  Ser Thr Thr Ser Thr  Ile Ser Ala 
    4175                 4180                 4185             


Pro Thr  Thr Ser Thr Ile Ser  Ser Pro Thr Ser Ser  Thr Thr Ser 
    4190                 4195                 4200             


Thr Pro  Gln Thr Ser Lys Thr  Ser Ala Ala Thr Ser  Ser Thr Thr 
    4205                 4210                 4215             


Ser Gly  Ser Gly Thr Thr Pro  Ser Pro Val Pro Thr  Thr Ser Thr 
    4220                 4225                 4230             


Thr Ser  Ala Ser Thr Thr Ser  Thr Thr Ser Ala Pro  Thr Thr Ser 
    4235                 4240                 4245             


Thr Thr  Ser Gly Pro Gly Thr  Thr Pro Ser Pro Val  Pro Ser Thr 
    4250                 4255                 4260             


Ser Thr  Thr Ser Ala Ala Thr  Thr Ser Thr Thr Ser  Ala Pro Thr 
    4265                 4270                 4275             


Thr Arg  Thr Thr Ser Ala Pro  Thr Ser Ser Met Thr  Ser Gly Pro 
    4280                 4285                 4290             


Gly Thr  Thr Pro Ser Pro Val  Pro Thr Thr Ser Thr  Thr Ser Ala 
    4295                 4300                 4305             


Pro Thr  Thr Ser Thr Thr Ser  Gly Pro Gly Thr Thr  Pro Ser Pro 
    4310                 4315                 4320             


Val Pro  Thr Thr Ser Thr Thr  Ser Ala Pro Ile Thr  Ser Thr Thr 
    4325                 4330                 4335             


Ser Gly  Pro Gly Ser Thr Pro  Ser Pro Val Pro Thr  Thr Ser Thr 
    4340                 4345                 4350             


Thr Ser  Ala Pro Thr Thr Ser  Thr Thr Ser Ala Ser  Thr Ala Ser 
    4355                 4360                 4365             


Thr Thr  Ser Gly Pro Gly Thr  Thr Pro Ser Pro Val  Pro Thr Thr 
    4370                 4375                 4380             


Ser Thr  Thr Ser Ala Pro Thr  Thr Arg Thr Thr Ser  Ala Ser Thr 
    4385                 4390                 4395             


Ala Ser  Thr Thr Ser Gly Pro  Gly Ser Thr Pro Ser  Pro Val Pro 
    4400                 4405                 4410             


Thr Thr  Ser Thr Thr Ser Ala  Pro Thr Thr Arg Thr  Thr Pro Ala 
    4415                 4420                 4425             


Ser Thr  Ala Ser Thr Thr Ser  Gly Pro Gly Thr Thr  Pro Ser Pro 
    4430                 4435                 4440             


Val Pro  Thr Thr Ser Thr Thr  Ser Ala Ser Thr Thr  Ser Thr Ile 
    4445                 4450                 4455             


Ser Leu  Pro Thr Thr Ser Thr  Thr Ser Ala Pro Ile  Thr Ser Met 
    4460                 4465                 4470             


Thr Ser  Gly Pro Gly Thr Thr  Pro Ser Pro Val Pro  Thr Thr Ser 
    4475                 4480                 4485             


Thr Thr  Ser Ala Pro Thr Thr  Ser Thr Thr Ser Ala  Ser Thr Ala 
    4490                 4495                 4500             


Ser Thr  Thr Ser Gly Pro Gly  Thr Thr Pro Ser Pro  Val Pro Thr 
    4505                 4510                 4515             


Thr Ser  Thr Thr Ser Ala Pro  Thr Thr Ser Thr Thr  Ser Ala Ser 
    4520                 4525                 4530             


Thr Ala  Ser Thr Thr Ser Gly  Pro Gly Thr Ser Leu  Ser Pro Val 
    4535                 4540                 4545             


Pro Thr  Thr Ser Thr Thr Ser  Ala Pro Thr Thr Ser  Thr Thr Ser 
    4550                 4555                 4560             


Gly Pro  Gly Thr Thr Pro Ser  Pro Val Pro Thr Thr  Ser Thr Thr 
    4565                 4570                 4575             


Ser Ala  Pro Thr Thr Ser Thr  Thr Ser Gly Pro Gly  Thr Thr Pro 
    4580                 4585                 4590             


Ser Pro  Val Pro Thr Thr Ser  Thr Thr Pro Val Ser  Lys Thr Ser 
    4595                 4600                 4605             


Thr Ser  His Leu Ser Val Ser  Lys Thr Thr His Ser  Gln Pro Val 
    4610                 4615                 4620             


Thr Ser  Asp Cys His Pro Leu  Cys Ala Trp Thr Lys  Trp Phe Asp 
    4625                 4630                 4635             


Val Asp  Phe Pro Ser Pro Gly  Pro His Gly Gly Asp  Lys Glu Thr 
    4640                 4645                 4650             


Tyr Asn  Asn Ile Ile Arg Ser  Gly Glu Lys Ile Cys  Arg Arg Pro 
    4655                 4660                 4665             


Glu Glu  Ile Thr Arg Leu Gln  Cys Arg Ala Glu Ser  His Pro Glu 
    4670                 4675                 4680             


Val Asn  Ile Glu His Leu Gly  Gln Val Val Gln Cys  Ser Arg Glu 
    4685                 4690                 4695             


Glu Gly  Leu Val Cys Arg Asn  Gln Asp Gln Gln Gly  Pro Phe Lys 
    4700                 4705                 4710             


Met Cys  Leu Asn Tyr Glu Val  Arg Val Leu Cys Cys  Glu Thr Pro 
    4715                 4720                 4725             


Arg Gly  Cys Pro Val Thr Ser  Val Thr Pro Tyr Gly  Thr Ser Pro 
    4730                 4735                 4740             


Thr Asn  Ala Leu Tyr Pro Ser  Leu Ser Thr Ser Met  Val Ser Ala 
    4745                 4750                 4755             


Ser Val  Ala Ser Thr Ser Val  Ala Ser Ser Ser Val  Ala Ser Ser 
    4760                 4765                 4770             


Ser Val  Ala Tyr Ser Thr Gln  Thr Cys Phe Cys Asn  Val Ala Asp 
    4775                 4780                 4785             


Arg Leu  Tyr Pro Ala Gly Ser  Thr Ile Tyr Arg His  Arg Asp Leu 
    4790                 4795                 4800             


Ala Gly  His Cys Tyr Tyr Ala  Leu Cys Ser Gln Asp  Cys Gln Val 
    4805                 4810                 4815             


Val Arg  Gly Val Asp Ser Asp  Cys Pro Ser Thr Thr  Leu Pro Pro 
    4820                 4825                 4830             


Ala Pro  Ala Thr Ser Pro Ser  Ile Ser Thr Ser Glu  Pro Val Thr 
    4835                 4840                 4845             


Glu Leu  Gly Cys Pro Asn Ala  Val Pro Pro Arg Lys  Lys Gly Glu 
    4850                 4855                 4860             


Thr Trp  Ala Thr Pro Asn Cys  Ser Glu Ala Thr Cys  Glu Gly Asn 
    4865                 4870                 4875             


Asn Val  Ile Ser Leu Arg Pro  Arg Thr Cys Pro Arg  Val Glu Lys 
    4880                 4885                 4890             


Pro Thr  Cys Ala Asn Gly Tyr  Pro Ala Val Lys Val  Ala Asp Gln 
    4895                 4900                 4905             


Asp Gly  Cys Cys His His Tyr  Gln Cys Gln Cys Val  Cys Ser Gly 
    4910                 4915                 4920             


Trp Gly  Asp Pro His Tyr Ile  Thr Phe Asp Gly Thr  Tyr Tyr Thr 
    4925                 4930                 4935             


Phe Leu  Asp Asn Cys Thr Tyr  Val Leu Val Gln Gln  Ile Val Pro 
    4940                 4945                 4950             


Val Tyr  Gly His Phe Arg Val  Leu Val Asp Asn Tyr  Phe Cys Gly 
    4955                 4960                 4965             


Ala Glu  Asp Gly Leu Ser Cys  Pro Arg Ser Ile Ile  Leu Glu Tyr 
    4970                 4975                 4980             


His Gln  Asp Arg Val Val Leu  Thr Arg Lys Pro Val  His Gly Val 
    4985                 4990                 4995             


Met Thr  Asn Glu Ile Ile Phe  Asn Asn Lys Val Val  Ser Pro Gly 
    5000                 5005                 5010             


Phe Arg  Lys Asn Gly Ile Val  Val Ser Arg Ile Gly  Val Lys Met 
    5015                 5020                 5025             


Tyr Ala  Thr Ile Pro Glu Leu  Gly Val Gln Val Met  Phe Ser Gly 
    5030                 5035                 5040             


Leu Ile  Phe Ser Val Glu Val  Pro Phe Ser Lys Phe  Ala Asn Asn 
    5045                 5050                 5055             


Thr Glu  Gly Gln Cys Gly Thr  Cys Thr Asn Asp Arg  Lys Asp Glu 
    5060                 5065                 5070             


Cys Arg  Thr Pro Arg Gly Thr  Val Val Ala Ser Cys  Ser Glu Met 
    5075                 5080                 5085             


Ser Gly  Leu Trp Asn Val Ser  Ile Pro Asp Gln Pro  Ala Cys His 
    5090                 5095                 5100             


Arg Pro  His Pro Thr Pro Thr  Thr Val Gly Pro Thr  Thr Val Gly 
    5105                 5110                 5115             


Ser Thr  Thr Val Gly Pro Thr  Thr Val Gly Ser Thr  Thr Val Gly 
    5120                 5125                 5130             


Pro Thr  Thr Pro Pro Ala Pro  Cys Leu Pro Ser Pro  Ile Cys Gln 
    5135                 5140                 5145             


Leu Ile  Leu Ser Lys Val Phe  Glu Pro Cys His Thr  Val Ile Pro 
    5150                 5155                 5160             


Pro Leu  Leu Phe Tyr Glu Gly  Cys Val Phe Asp Arg  Cys His Met 
    5165                 5170                 5175             


Thr Asp  Leu Asp Val Val Cys  Ser Ser Leu Glu Leu  Tyr Ala Ala 
    5180                 5185                 5190             


Leu Cys  Ala Ser His Asp Ile  Cys Ile Asp Trp Arg  Gly Arg Thr 
    5195                 5200                 5205             


Gly His  Met Cys Pro Phe Thr  Cys Pro Ala Asp Lys  Val Tyr Gln 
    5210                 5215                 5220             


Pro Cys  Gly Pro Ser Asn Pro  Ser Tyr Cys Tyr Gly  Asn Asp Ser 
    5225                 5230                 5235             


Ala Ser  Leu Gly Ala Leu Pro  Glu Ala Gly Pro Ile  Thr Glu Gly 
    5240                 5245                 5250             


Cys Phe  Cys Pro Glu Gly Met  Thr Leu Phe Ser Thr  Ser Ala Gln 
    5255                 5260                 5265             


Val Cys  Val Pro Thr Gly Cys  Pro Arg Cys Leu Gly  Pro His Gly 
    5270                 5275                 5280             


Glu Pro  Val Lys Val Gly His  Thr Val Gly Met Asp  Cys Gln Glu 
    5285                 5290                 5295             


Cys Thr  Cys Glu Ala Ala Thr  Trp Thr Leu Thr Cys  Arg Pro Lys 
    5300                 5305                 5310             


Leu Cys  Pro Leu Pro Pro Ala  Cys Pro Leu Pro Gly  Phe Val Pro 
    5315                 5320                 5325             


Val Pro  Ala Ala Pro Gln Ala  Gly Gln Cys Cys Pro  Gln Tyr Ser 
    5330                 5335                 5340             


Cys Ala  Cys Asn Thr Ser Arg  Cys Pro Ala Pro Val  Gly Cys Pro 
    5345                 5350                 5355             


Glu Gly  Ala Arg Ala Ile Pro  Thr Tyr Gln Glu Gly  Ala Cys Cys 
    5360                 5365                 5370             


Pro Val  Gln Asn Cys Ser Trp  Thr Val Cys Ser Ile  Asn Gly Thr 
    5375                 5380                 5385             


Leu Tyr  Gln Pro Gly Ala Val  Val Ser Ser Ser Leu  Cys Glu Thr 
    5390                 5395                 5400             


Cys Arg  Cys Glu Leu Pro Gly  Gly Pro Pro Ser Asp  Ala Phe Val 
    5405                 5410                 5415             


Val Ser  Cys Glu Thr Gln Ile  Cys Asn Thr His Cys  Pro Val Gly 
    5420                 5425                 5430             


Phe Glu  Tyr Gln Glu Gln Ser  Gly Gln Cys Cys Gly  Thr Cys Val 
    5435                 5440                 5445             


Gln Val  Ala Cys Val Thr Asn  Thr Ser Lys Ser Pro  Ala His Leu 
    5450                 5455                 5460             


Phe Tyr  Pro Gly Glu Thr Trp  Ser Asp Ala Gly Asn  His Cys Val 
    5465                 5470                 5475             


Thr His  Gln Cys Glu Lys His  Gln Asp Gly Leu Val  Val Val Thr 
    5480                 5485                 5490             


Thr Lys  Lys Ala Cys Pro Pro  Leu Ser Cys Ser Leu  Asp Glu Ala 
    5495                 5500                 5505             


Arg Met  Ser Lys Asp Gly Cys  Cys Arg Phe Cys Pro  Pro Pro Pro 
    5510                 5515                 5520             


Pro Pro  Tyr Gln Asn Gln Ser  Thr Cys Ala Val Tyr  His Arg Ser 
    5525                 5530                 5535             


Leu Ile  Ile Gln Gln Gln Gly  Cys Ser Ser Ser Glu  Pro Val Arg 
    5540                 5545                 5550             


Leu Ala  Tyr Cys Arg Gly Asn  Cys Gly Asp Ser Ser  Ser Met Tyr 
    5555                 5560                 5565             


Ser Leu  Glu Gly Asn Thr Val  Glu His Arg Cys Gln  Cys Cys Gln 
    5570                 5575                 5580             


Glu Leu  Arg Thr Ser Leu Arg  Asn Val Thr Leu His  Cys Thr Asp 
    5585                 5590                 5595             


Gly Ser  Ser Arg Ala Phe Ser  Tyr Thr Glu Val Glu  Glu Cys Gly 
    5600                 5605                 5610             


Cys Met  Gly Arg Arg Cys Pro  Ala Pro Gly Asp Thr  Gln His Ser 
    5615                 5620                 5625             


Glu Glu  Ala Glu Pro Glu Pro  Ser Gln Glu Ala Glu  Ser Gly Ser 
    5630                 5635                 5640             


Trp Glu  Arg Gly Val Pro Val  Ser Pro Met His 
    5645                 5650                 


<210>  9106
<211>  5762
<212>  PRT
<213>  Homo Sapiens

<400>  9106

Met Gly Ala Pro Ser Ala Cys Arg Thr Leu Val Leu Ala Leu Ala Ala 
1               5                   10                  15      


Met Leu Val Val Pro Gln Ala Glu Thr Gln Gly Pro Val Glu Pro Ser 
            20                  25                  30          


Trp Glu Asn Ala Gly His Thr Met Asp Gly Gly Ala Pro Thr Ser Ser 
        35                  40                  45              


Pro Thr Arg Arg Val Ser Phe Val Pro Pro Val Thr Val Phe Pro Ser 
    50                  55                  60                  


Leu Ser Pro Leu Asn Pro Ala His Asn Gly Arg Val Cys Ser Thr Trp 
65                  70                  75                  80  


Gly Asp Phe His Tyr Lys Thr Phe Asp Gly Asp Val Phe Arg Phe Pro 
                85                  90                  95      


Gly Leu Cys Asn Tyr Val Phe Ser Glu His Cys Arg Ala Ala Tyr Glu 
            100                 105                 110         


Asp Phe Asn Val Gln Leu Arg Arg Gly Leu Val Gly Ser Arg Pro Val 
        115                 120                 125             


Val Thr Arg Val Val Ile Lys Ala Gln Gly Leu Val Leu Glu Ala Ser 
    130                 135                 140                 


Asn Gly Ser Val Leu Ile Asn Gly Gln Arg Glu Glu Leu Pro Tyr Ser 
145                 150                 155                 160 


Arg Thr Gly Leu Leu Val Glu Gln Ser Gly Asp Tyr Ile Lys Val Ser 
                165                 170                 175     


Ile Arg Leu Val Leu Thr Phe Leu Trp Asn Gly Glu Asp Ser Ala Leu 
            180                 185                 190         


Leu Glu Leu Asp Pro Lys Tyr Ala Asn Gln Thr Cys Gly Leu Cys Gly 
        195                 200                 205             


Asp Phe Asn Gly Leu Pro Ala Phe Asn Glu Phe Tyr Ala His Asn Ala 
    210                 215                 220                 


Arg Leu Thr Pro Leu Gln Phe Gly Asn Leu Gln Lys Leu Asp Gly Pro 
225                 230                 235                 240 


Thr Glu Gln Cys Pro Asp Pro Leu Pro Leu Pro Ala Gly Asn Cys Thr 
                245                 250                 255     


Asp Glu Glu Gly Ile Cys His Arg Thr Leu Leu Gly Pro Ala Phe Ala 
            260                 265                 270         


Glu Cys His Ala Leu Val Asp Ser Thr Ala Tyr Leu Ala Ala Cys Ala 
        275                 280                 285             


Gln Asp Leu Cys Arg Cys Pro Thr Cys Pro Cys Ala Thr Phe Val Glu 
    290                 295                 300                 


Tyr Ser Arg Gln Cys Ala His Ala Gly Gly Gln Pro Arg Asn Trp Arg 
305                 310                 315                 320 


Cys Pro Glu Leu Cys Pro Arg Thr Cys Pro Leu Asn Met Gln His Gln 
                325                 330                 335     


Glu Cys Gly Ser Pro Cys Thr Asp Thr Cys Ser Asn Pro Gln Arg Ala 
            340                 345                 350         


Gln Leu Cys Glu Asp His Cys Val Asp Gly Cys Phe Cys Pro Pro Gly 
        355                 360                 365             


Thr Val Leu Asp Asp Ile Thr His Ser Gly Cys Leu Pro Leu Gly Gln 
    370                 375                 380                 


Cys Pro Cys Thr His Gly Gly Arg Thr Tyr Ser Pro Gly Thr Ser Phe 
385                 390                 395                 400 


Asn Thr Thr Cys Ser Ser Cys Thr Cys Ser Gly Gly Leu Trp Gln Cys 
                405                 410                 415     


Gln Asp Leu Pro Cys Pro Gly Thr Cys Ser Val Gln Gly Gly Ala His 
            420                 425                 430         


Ile Ser Thr Tyr Asp Glu Lys Leu Tyr Asp Leu His Gly Asp Cys Ser 
        435                 440                 445             


Tyr Val Leu Ser Lys Lys Cys Ala Asp Ser Ser Phe Thr Val Leu Ala 
    450                 455                 460                 


Glu Leu Arg Lys Cys Gly Leu Thr Asp Asn Glu Asn Cys Leu Lys Ala 
465                 470                 475                 480 


Val Thr Leu Ser Leu Asp Gly Gly Asp Thr Ala Ile Arg Val Gln Ala 
                485                 490                 495     


Asp Gly Gly Val Phe Leu Asn Ser Ile Tyr Thr Gln Leu Pro Leu Ser 
            500                 505                 510         


Ala Ala Asn Ile Thr Leu Phe Thr Pro Ser Ser Phe Phe Ile Val Val 
        515                 520                 525             


Gln Thr Gly Leu Gly Leu Gln Leu Leu Val Gln Leu Val Pro Leu Met 
    530                 535                 540                 


Gln Val Phe Val Arg Leu Asp Pro Ala His Gln Gly Gln Met Cys Gly 
545                 550                 555                 560 


Leu Cys Gly Asn Phe Asn Gln Asn Gln Ala Asp Asp Phe Thr Ala Leu 
                565                 570                 575     


Ser Gly Val Val Glu Ala Thr Gly Ala Ala Phe Ala Asn Thr Trp Lys 
            580                 585                 590         


Ala Gln Ala Ala Cys Ala Asn Ala Arg Asn Ser Phe Glu Asp Pro Cys 
        595                 600                 605             


Ser Leu Ser Val Glu Asn Glu Asn Tyr Ala Arg His Trp Cys Ser Arg 
    610                 615                 620                 


Leu Thr Asp Pro Asn Ser Ala Phe Ser Arg Cys His Ser Ile Ile Asn 
625                 630                 635                 640 


Pro Lys Pro Phe His Ser Asn Cys Met Phe Asp Thr Cys Asn Cys Glu 
                645                 650                 655     


Arg Ser Glu Asp Cys Leu Cys Ala Ala Leu Ser Ser Tyr Val His Ala 
            660                 665                 670         


Cys Ala Ala Lys Gly Val Gln Leu Ser Asp Trp Arg Asp Gly Val Cys 
        675                 680                 685             


Thr Lys Tyr Met Gln Asn Cys Pro Lys Ser Gln Arg Tyr Ala Tyr Val 
    690                 695                 700                 


Val Asp Ala Cys Gln Pro Thr Cys Arg Gly Leu Ser Glu Ala Asp Val 
705                 710                 715                 720 


Thr Cys Ser Val Ser Phe Val Pro Val Asp Gly Cys Thr Cys Pro Ala 
                725                 730                 735     


Gly Thr Phe Leu Asn Asp Ala Gly Ala Cys Val Pro Ala Gln Glu Cys 
            740                 745                 750         


Pro Cys Tyr Ala His Gly Thr Val Leu Ala Pro Gly Glu Val Val His 
        755                 760                 765             


Asp Glu Gly Ala Val Cys Ser Cys Thr Gly Gly Lys Leu Ser Cys Leu 
    770                 775                 780                 


Gly Ala Ser Leu Gln Lys Ser Thr Gly Cys Ala Ala Pro Met Val Tyr 
785                 790                 795                 800 


Leu Asp Cys Ser Asn Ser Ser Ala Gly Thr Pro Gly Ala Glu Cys Leu 
                805                 810                 815     


Arg Ser Cys His Thr Leu Asp Val Gly Cys Phe Ser Thr His Cys Val 
            820                 825                 830         


Ser Gly Cys Val Cys Pro Pro Gly Leu Val Ser Asp Gly Ser Gly Gly 
        835                 840                 845             


Cys Ile Ala Glu Glu Asp Cys Pro Cys Val His Asn Glu Ala Thr Tyr 
    850                 855                 860                 


Lys Pro Gly Glu Thr Ile Arg Val Asp Cys Asn Thr Cys Thr Cys Arg 
865                 870                 875                 880 


Asn Arg Arg Trp Glu Cys Ser His Arg Leu Cys Leu Gly Thr Cys Val 
                885                 890                 895     


Ala Tyr Gly Asp Gly His Phe Ile Thr Phe Asp Gly Asp Arg Tyr Ser 
            900                 905                 910         


Phe Glu Gly Ser Cys Glu Tyr Ile Leu Ala Gln Asp Tyr Cys Gly Asp 
        915                 920                 925             


Asn Thr Thr His Gly Thr Phe Arg Ile Val Thr Glu Asn Ile Pro Cys 
    930                 935                 940                 


Gly Thr Thr Gly Thr Thr Cys Ser Lys Ala Ile Lys Leu Phe Val Glu 
945                 950                 955                 960 


Ser Tyr Glu Leu Ile Leu Gln Glu Gly Thr Phe Lys Ala Val Ala Arg 
                965                 970                 975     


Gly Pro Gly Gly Asp Pro Pro Tyr Lys Ile Arg Tyr Met Gly Ile Phe 
            980                 985                 990         


Leu Val Ile Glu Thr His Gly Met  Ala Val Ser Trp Asp  Arg Lys Thr 
        995                 1000                 1005             


Ser Val  Phe Ile Arg Leu His  Gln Asp Tyr Lys Gly  Arg Val Cys 
    1010                 1015                 1020             


Gly Leu  Cys Gly Asn Phe Asp  Asp Asn Ala Ile Asn  Asp Phe Ala 
    1025                 1030                 1035             


Thr Arg  Ser Arg Ser Val Val  Gly Asp Ala Leu Glu  Phe Gly Asn 
    1040                 1045                 1050             


Ser Trp  Lys Leu Ser Pro Ser  Cys Pro Asp Ala Leu  Ala Pro Lys 
    1055                 1060                 1065             


Asp Pro  Cys Thr Ala Asn Pro  Phe Arg Lys Ser Trp  Ala Gln Lys 
    1070                 1075                 1080             


Gln Cys  Ser Ile Leu His Gly  Pro Thr Phe Ala Ala  Cys Arg Ser 
    1085                 1090                 1095             


Gln Val  Asp Ser Thr Lys Tyr  Tyr Glu Ala Cys Val  Asn Asp Ala 
    1100                 1105                 1110             


Cys Ala  Cys Asp Ser Gly Gly  Asp Cys Glu Cys Phe  Cys Thr Ala 
    1115                 1120                 1125             


Val Ala  Ala Tyr Ala Gln Ala  Cys His Asp Ala Gly  Leu Cys Val 
    1130                 1135                 1140             


Ser Trp  Arg Thr Pro Asp Thr  Cys Pro Leu Phe Cys  Asp Phe Tyr 
    1145                 1150                 1155             


Asn Pro  His Gly Gly Cys Glu  Trp His Tyr Gln Pro  Cys Gly Ala 
    1160                 1165                 1170             


Pro Cys  Leu Lys Thr Cys Arg  Asn Pro Ser Gly His  Cys Leu Val 
    1175                 1180                 1185             


Asp Leu  Pro Gly Leu Glu Gly  Cys Tyr Pro Lys Cys  Pro Pro Ser 
    1190                 1195                 1200             


Gln Pro  Phe Phe Asn Glu Asp  Gln Met Lys Cys Val  Ala Gln Cys 
    1205                 1210                 1215             


Gly Cys  Tyr Asp Lys Asp Gly  Asn Tyr Tyr Asp Val  Gly Ala Arg 
    1220                 1225                 1230             


Val Pro  Thr Ala Glu Asn Cys  Gln Ser Cys Asn Cys  Thr Pro Ser 
    1235                 1240                 1245             


Gly Ile  Gln Cys Ala His Ser  Leu Glu Ala Cys Thr  Cys Thr Tyr 
    1250                 1255                 1260             


Glu Asp  Arg Thr Tyr Ser Tyr  Gln Asp Val Ile Tyr  Asn Thr Thr 
    1265                 1270                 1275             


Asp Gly  Leu Gly Ala Cys Leu  Ile Ala Ile Cys Gly  Ser Asn Gly 
    1280                 1285                 1290             


Thr Ile  Ile Arg Lys Ala Val  Ala Cys Pro Gly Thr  Pro Ala Thr 
    1295                 1300                 1305             


Thr Pro  Phe Thr Phe Thr Thr  Ala Trp Val Pro His  Ser Thr Thr 
    1310                 1315                 1320             


Ser Pro  Ala Leu Pro Val Ser  Thr Val Cys Val Arg  Glu Val Cys 
    1325                 1330                 1335             


Arg Trp  Ser Ser Trp Tyr Asn  Gly His Arg Pro Glu  Pro Gly Leu 
    1340                 1345                 1350             


Gly Gly  Gly Asp Phe Glu Thr  Phe Glu Asn Leu Arg  Gln Arg Gly 
    1355                 1360                 1365             


Tyr Gln  Val Cys Pro Val Leu  Ala Asp Ile Glu Cys  Arg Ala Ala 
    1370                 1375                 1380             


Gln Leu  Pro Asp Met Pro Leu  Glu Glu Leu Gly Gln  Gln Val Asp 
    1385                 1390                 1395             


Cys Asp  Arg Met Arg Gly Leu  Met Cys Ala Asn Ser  Gln Gln Ser 
    1400                 1405                 1410             


Pro Pro  Leu Cys His Asp Tyr  Glu Leu Arg Val Leu  Cys Cys Glu 
    1415                 1420                 1425             


Tyr Val  Pro Cys Gly Pro Ser  Pro Ala Pro Gly Thr  Ser Pro Gln 
    1430                 1435                 1440             


Pro Ser  Leu Ser Ala Ser Thr  Glu Pro Ala Val Pro  Thr Pro Thr 
    1445                 1450                 1455             


Gln Thr  Thr Ala Thr Glu Lys  Thr Thr Leu Trp Val  Thr Pro Ser 
    1460                 1465                 1470             


Ile Arg  Ser Thr Ala Ala Leu  Thr Ser Gln Thr Gly  Ser Ser Ser 
    1475                 1480                 1485             


Gly Pro  Val Thr Val Thr Pro  Ser Ala Pro Gly Thr  Thr Thr Cys 
    1490                 1495                 1500             


Gln Pro  Arg Cys Gln Trp Thr  Glu Trp Phe Asp Glu  Asp Tyr Pro 
    1505                 1510                 1515             


Lys Ser  Glu Gln Leu Gly Gly  Asp Val Glu Ser Tyr  Asp Lys Ile 
    1520                 1525                 1530             


Arg Ala  Ala Gly Gly His Leu  Cys Gln Gln Pro Lys  Asp Ile Glu 
    1535                 1540                 1545             


Cys Gln  Ala Glu Ser Phe Pro  Asn Trp Thr Leu Ala  Gln Val Gly 
    1550                 1555                 1560             


Gln Lys  Val His Cys Asp Val  His Phe Gly Leu Val  Cys Arg Asn 
    1565                 1570                 1575             


Trp Glu  Gln Glu Gly Val Phe  Lys Met Cys Tyr Asn  Tyr Arg Ile 
    1580                 1585                 1590             


Arg Val  Leu Cys Cys Ser Asp  Asp His Cys Arg Gly  Arg Ala Thr 
    1595                 1600                 1605             


Thr Pro  Pro Pro Thr Thr Glu  Leu Glu Thr Ala Thr  Thr Thr Thr 
    1610                 1615                 1620             


Thr Gln  Ala Leu Phe Ser Thr  Pro Gln Pro Thr Ser  Ser Pro Gly 
    1625                 1630                 1635             


Leu Thr  Arg Ala Pro Pro Ala  Ser Thr Thr Ala Val  Pro Thr Leu 
    1640                 1645                 1650             


Ser Glu  Gly Leu Thr Ser Pro  Arg Tyr Thr Ser Thr  Leu Gly Thr 
    1655                 1660                 1665             


Ala Thr  Thr Gly Gly Pro Thr  Thr Pro Ala Gly Ser  Thr Glu Pro 
    1670                 1675                 1680             


Thr Val  Pro Gly Val Ala Thr  Ser Thr Leu Pro Thr  Arg Ser Ala 
    1685                 1690                 1695             


Leu Pro  Gly Thr Thr Gly Ser  Leu Gly Thr Trp Arg  Pro Ser Gln 
    1700                 1705                 1710             


Pro Pro  Thr Leu Ala Pro Thr  Thr Met Ala Thr Ser  Arg Ala Arg 
    1715                 1720                 1725             


Pro Thr  Gly Thr Ala Ser Thr  Ala Ser Lys Glu Pro  Leu Thr Thr 
    1730                 1735                 1740             


Ser Leu  Ala Pro Thr Leu Thr  Ser Glu Leu Ser Thr  Ser Gln Ala 
    1745                 1750                 1755             


Glu Thr  Ser Thr Pro Arg Thr  Glu Thr Thr Met Ser  Pro Leu Thr 
    1760                 1765                 1770             


Asn Thr  Thr Thr Ser Gln Gly  Thr Thr Arg Cys Gln  Pro Lys Cys 
    1775                 1780                 1785             


Glu Trp  Thr Glu Trp Phe Asp  Val Asp Phe Pro Thr  Ser Gly Val 
    1790                 1795                 1800             


Ala Gly  Gly Asp Met Glu Thr  Phe Glu Asn Ile Arg  Ala Ala Gly 
    1805                 1810                 1815             


Gly Lys  Met Cys Trp Ala Pro  Lys Ser Ile Glu Cys  Arg Ala Glu 
    1820                 1825                 1830             


Asn Tyr  Pro Glu Val Ser Ile  Asp Gln Val Gly Gln  Val Leu Thr 
    1835                 1840                 1845             


Cys Ser  Leu Glu Thr Gly Leu  Thr Cys Lys Asn Glu  Asp Gln Thr 
    1850                 1855                 1860             


Gly Arg  Phe Asn Met Cys Phe  Asn Tyr Asn Val Arg  Val Leu Cys 
    1865                 1870                 1875             


Cys Asp  Asp Tyr Ser His Cys  Pro Ser Thr Pro Ala  Thr Ser Ser 
    1880                 1885                 1890             


Thr Ala  Thr Pro Ser Ser Thr  Pro Gly Thr Thr Trp  Ile Leu Thr 
    1895                 1900                 1905             


Lys Pro  Thr Thr Thr Ala Thr  Thr Thr Ala Ser Thr  Gly Ser Thr 
    1910                 1915                 1920             


Ala Thr  Pro Thr Ser Thr Leu  Arg Thr Ala Pro Pro  Pro Lys Val 
    1925                 1930                 1935             


Leu Thr  Thr Thr Ala Thr Thr  Pro Thr Val Thr Ser  Ser Lys Ala 
    1940                 1945                 1950             


Thr Pro  Ser Ser Ser Pro Gly  Thr Ala Thr Ala Leu  Pro Ala Leu 
    1955                 1960                 1965             


Arg Ser  Thr Ala Thr Thr Pro  Thr Ala Thr Ser Val  Thr Pro Ile 
    1970                 1975                 1980             


Pro Ser  Ser Ser Leu Gly Thr  Thr Trp Thr Arg Leu  Ser Gln Thr 
    1985                 1990                 1995             


Thr Thr  Pro Thr Ala Thr Met  Ser Thr Ala Thr Pro  Ser Ser Thr 
    2000                 2005                 2010             


Pro Glu  Thr Ala His Thr Ser  Thr Val Leu Thr Ala  Thr Ala Thr 
    2015                 2020                 2025             


Thr Thr  Gly Ala Thr Gly Ser  Val Ala Thr Pro Ser  Ser Thr Pro 
    2030                 2035                 2040             


Gly Thr  Ala His Thr Thr Lys  Val Pro Thr Thr Thr  Thr Thr Gly 
    2045                 2050                 2055             


Phe Thr  Ala Thr Pro Ser Ser  Ser Pro Gly Thr Ala  Leu Thr Pro 
    2060                 2065                 2070             


Pro Val  Trp Ile Ser Thr Thr  Thr Thr Pro Thr Thr  Arg Gly Ser 
    2075                 2080                 2085             


Thr Val  Thr Pro Ser Ser Ile  Pro Gly Thr Thr His  Thr Ala Thr 
    2090                 2095                 2100             


Val Leu  Thr Thr Thr Thr Thr  Thr Val Ala Thr Gly  Ser Met Ala 
    2105                 2110                 2115             


Thr Pro  Ser Ser Ser Thr Gln  Thr Ser Gly Thr Pro  Pro Ser Leu 
    2120                 2125                 2130             


Thr Thr  Thr Ala Thr Thr Ile  Thr Ala Thr Gly Ser  Thr Thr Asn 
    2135                 2140                 2145             


Pro Ser  Ser Thr Pro Gly Thr  Thr Pro Ile Pro Pro  Val Leu Thr 
    2150                 2155                 2160             


Thr Thr  Ala Thr Thr Pro Ala  Ala Thr Ser Asn Thr  Val Thr Pro 
    2165                 2170                 2175             


Ser Ser  Ala Leu Gly Thr Thr  His Thr Pro Pro Val  Pro Asn Thr 
    2180                 2185                 2190             


Met Ala  Thr Thr His Gly Arg  Ser Leu Pro Pro Ser  Ser Pro His 
    2195                 2200                 2205             


Thr Val  Arg Thr Ala Trp Thr  Ser Ala Thr Ser Gly  Ile Leu Gly 
    2210                 2215                 2220             


Thr Thr  His Ile Thr Glu Pro  Ser Thr Val Thr Ser  His Thr Leu 
    2225                 2230                 2235             


Ala Ala  Thr Thr Gly Thr Thr  Gln His Ser Thr Pro  Ala Leu Ser 
    2240                 2245                 2250             


Ser Pro  His Pro Ser Ser Arg  Thr Thr Glu Ser Pro  Pro Ser Pro 
    2255                 2260                 2265             


Gly Thr  Thr Thr Pro Gly His  Thr Thr Ala Thr Ser  Arg Thr Thr 
    2270                 2275                 2280             


Ala Thr  Ala Thr Pro Ser Lys  Thr Arg Thr Ser Thr  Leu Leu Pro 
    2285                 2290                 2295             


Ser Ser  Pro Thr Ser Ala Pro  Ile Thr Thr Val Val  Thr Met Gly 
    2300                 2305                 2310             


Cys Glu  Pro Gln Cys Ala Trp  Ser Glu Trp Leu Asp  Tyr Ser Tyr 
    2315                 2320                 2325             


Pro Met  Pro Gly Pro Ser Gly  Gly Asp Phe Asp Thr  Tyr Ser Asn 
    2330                 2335                 2340             


Ile Arg  Ala Ala Gly Gly Ala  Val Cys Glu Gln Pro  Leu Gly Leu 
    2345                 2350                 2355             


Glu Cys  Arg Ala Gln Ala Gln  Pro Gly Val Pro Leu  Arg Glu Leu 
    2360                 2365                 2370             


Gly Gln  Val Val Glu Cys Ser  Leu Asp Phe Gly Leu  Val Cys Arg 
    2375                 2380                 2385             


Asn Arg  Glu Gln Val Gly Lys  Phe Lys Met Cys Phe  Asn Tyr Glu 
    2390                 2395                 2400             


Ile Arg  Val Phe Cys Cys Asn  Tyr Gly His Cys Pro  Ser Thr Pro 
    2405                 2410                 2415             


Ala Thr  Ser Ser Thr Ala Met  Pro Ser Ser Thr Pro  Gly Thr Thr 
    2420                 2425                 2430             


Trp Ile  Leu Thr Glu Leu Thr  Thr Thr Ala Thr Thr  Thr Glu Ser 
    2435                 2440                 2445             


Thr Gly  Ser Thr Ala Thr Pro  Ser Ser Thr Pro Gly  Thr Thr Trp 
    2450                 2455                 2460             


Ile Leu  Thr Glu Pro Ser Thr  Thr Ala Thr Val Thr  Val Pro Thr 
    2465                 2470                 2475             


Gly Ser  Thr Ala Thr Ala Ser  Ser Thr Gln Ala Thr  Ala Gly Thr 
    2480                 2485                 2490             


Pro His  Val Ser Thr Thr Ala  Thr Thr Pro Thr Val  Thr Ser Ser 
    2495                 2500                 2505             


Lys Ala  Thr Pro Phe Ser Ser  Pro Gly Thr Ala Thr  Ala Leu Pro 
    2510                 2515                 2520             


Ala Leu  Arg Ser Thr Ala Thr  Thr Pro Thr Ala Thr  Ser Phe Thr 
    2525                 2530                 2535             


Ala Ile  Pro Ser Ser Ser Leu  Gly Thr Thr Trp Thr  Arg Leu Ser 
    2540                 2545                 2550             


Gln Thr  Thr Thr Pro Thr Ala  Thr Met Ser Thr Ala  Thr Pro Ser 
    2555                 2560                 2565             


Ser Thr  Pro Glu Thr Val His  Thr Ser Thr Val Leu  Thr Thr Thr 
    2570                 2575                 2580             


Ala Thr  Thr Thr Gly Ala Thr  Gly Ser Val Ala Thr  Pro Ser Ser 
    2585                 2590                 2595             


Thr Pro  Gly Thr Ala His Thr  Thr Lys Val Leu Thr  Thr Thr Thr 
    2600                 2605                 2610             


Thr Gly  Phe Thr Ala Thr Pro  Ser Ser Ser Pro Gly  Thr Ala Arg 
    2615                 2620                 2625             


Thr Leu  Pro Val Trp Ile Ser  Thr Thr Thr Thr Pro  Thr Thr Arg 
    2630                 2635                 2640             


Gly Ser  Thr Val Thr Pro Ser  Ser Ile Pro Gly Thr  Thr His Thr 
    2645                 2650                 2655             


Pro Thr  Val Leu Thr Thr Thr  Thr Thr Thr Val Ala  Thr Gly Ser 
    2660                 2665                 2670             


Met Ala  Thr Pro Ser Ser Ser  Thr Gln Thr Ser Gly  Thr Pro Pro 
    2675                 2680                 2685             


Ser Leu  Thr Thr Thr Ala Thr  Thr Ile Thr Ala Thr  Gly Ser Thr 
    2690                 2695                 2700             


Thr Asn  Pro Ser Ser Thr Pro  Gly Thr Thr Pro Ile  Pro Pro Val 
    2705                 2710                 2715             


Leu Thr  Thr Thr Ala Thr Thr  Pro Ala Ala Thr Ser  Ser Thr Val 
    2720                 2725                 2730             


Thr Pro  Ser Ser Ala Leu Gly  Thr Thr His Thr Pro  Pro Val Pro 
    2735                 2740                 2745             


Asn Thr  Thr Ala Thr Thr His  Gly Arg Ser Leu Ser  Pro Ser Ser 
    2750                 2755                 2760             


Pro His  Thr Val Arg Thr Ala  Trp Thr Ser Ala Thr  Ser Gly Thr 
    2765                 2770                 2775             


Leu Gly  Thr Thr His Ile Thr  Glu Pro Ser Thr Gly  Thr Ser His 
    2780                 2785                 2790             


Thr Pro  Ala Ala Thr Thr Gly  Thr Thr Gln His Ser  Thr Pro Ala 
    2795                 2800                 2805             


Leu Ser  Ser Pro His Pro Ser  Ser Arg Thr Thr Glu  Ser Pro Pro 
    2810                 2815                 2820             


Ser Pro  Gly Thr Thr Thr Pro  Gly His Thr Arg Ala  Thr Ser Arg 
    2825                 2830                 2835             


Thr Thr  Ala Thr Ala Thr Pro  Ser Lys Thr Arg Thr  Ser Thr Leu 
    2840                 2845                 2850             


Leu Pro  Ser Ser Pro Thr Ser  Ala Pro Ile Thr Thr  Val Val Thr 
    2855                 2860                 2865             


Met Gly  Cys Glu Pro Gln Cys  Ala Trp Ser Glu Trp  Leu Asp Tyr 
    2870                 2875                 2880             


Ser Tyr  Pro Met Pro Gly Pro  Ser Gly Gly Asp Phe  Asp Thr Tyr 
    2885                 2890                 2895             


Ser Asn  Ile Arg Ala Ala Gly  Gly Ala Val Cys Glu  Gln Pro Leu 
    2900                 2905                 2910             


Gly Leu  Glu Cys Arg Ala Gln  Ala Gln Pro Gly Val  Pro Leu Arg 
    2915                 2920                 2925             


Glu Leu  Gly Gln Val Val Glu  Cys Ser Leu Asp Phe  Gly Leu Val 
    2930                 2935                 2940             


Cys Arg  Asn Arg Glu Gln Val  Gly Lys Phe Lys Met  Cys Phe Asn 
    2945                 2950                 2955             


Tyr Glu  Ile Arg Val Phe Cys  Cys Asn Tyr Gly His  Cys Pro Ser 
    2960                 2965                 2970             


Thr Pro  Ala Thr Ser Ser Thr  Ala Thr Pro Ser Ser  Thr Pro Gly 
    2975                 2980                 2985             


Thr Thr  Trp Ile Leu Thr Glu  Gln Thr Thr Ala Ala  Thr Thr Thr 
    2990                 2995                 3000             


Ala Thr  Thr Gly Ser Thr Ala  Ile Pro Ser Ser Thr  Pro Gly Thr 
    3005                 3010                 3015             


Ala Pro  Pro Pro Lys Val Leu  Thr Ser Thr Ala Thr  Thr Pro Thr 
    3020                 3025                 3030             


Ala Thr  Ser Ser Lys Ala Thr  Ser Ser Ser Ser Pro  Arg Thr Ala 
    3035                 3040                 3045             


Thr Thr  Leu Pro Val Leu Thr  Ser Thr Ala Thr Lys  Ser Thr Ala 
    3050                 3055                 3060             


Thr Ser  Phe Thr Pro Ile Pro  Ser Phe Thr Leu Gly  Thr Thr Gly 
    3065                 3070                 3075             


Thr Leu  Pro Glu Gln Thr Thr  Thr Pro Met Ala Thr  Met Ser Thr 
    3080                 3085                 3090             


Ile His  Pro Ser Ser Thr Pro  Glu Thr Thr His Thr  Ser Thr Val 
    3095                 3100                 3105             


Leu Thr  Thr Lys Ala Thr Thr  Thr Arg Ala Thr Ser  Ser Met Ser 
    3110                 3115                 3120             


Thr Pro  Ser Ser Thr Pro Gly  Thr Thr Trp Ile Leu  Thr Glu Leu 
    3125                 3130                 3135             


Thr Thr  Ala Ala Thr Thr Thr  Ala Ala Thr Gly Pro  Thr Ala Thr 
    3140                 3145                 3150             


Pro Ser  Ser Thr Pro Gly Thr  Thr Trp Ile Leu Thr  Glu Pro Ser 
    3155                 3160                 3165             


Thr Thr  Ala Thr Val Thr Val  Pro Thr Gly Ser Thr  Ala Thr Ala 
    3170                 3175                 3180             


Ser Ser  Thr Arg Ala Thr Ala  Gly Thr Leu Lys Val  Leu Thr Ser 
    3185                 3190                 3195             


Thr Ala  Thr Thr Pro Thr Val  Ile Ser Ser Arg Ala  Thr Pro Ser 
    3200                 3205                 3210             


Ser Ser  Pro Gly Thr Ala Thr  Ala Leu Pro Ala Leu  Arg Ser Thr 
    3215                 3220                 3225             


Ala Thr  Thr Pro Thr Ala Thr  Ser Val Thr Ala Ile  Pro Ser Ser 
    3230                 3235                 3240             


Ser Leu  Gly Thr Ala Trp Thr  Arg Leu Ser Gln Thr  Thr Thr Pro 
    3245                 3250                 3255             


Thr Ala  Thr Met Ser Thr Ala  Thr Pro Ser Ser Thr  Pro Glu Thr 
    3260                 3265                 3270             


Val His  Thr Ser Thr Val Leu  Thr Thr Thr Thr Thr  Thr Thr Arg 
    3275                 3280                 3285             


Ala Thr  Gly Ser Val Ala Thr  Pro Ser Ser Thr Pro  Gly Thr Ala 
    3290                 3295                 3300             


His Thr  Thr Lys Val Pro Thr  Thr Thr Thr Thr Gly  Phe Thr Ala 
    3305                 3310                 3315             


Thr Pro  Ser Ser Ser Pro Gly  Thr Ala Leu Thr Pro  Pro Val Trp 
    3320                 3325                 3330             


Ile Ser  Thr Thr Thr Thr Pro  Thr Thr Arg Gly Ser  Thr Val Thr 
    3335                 3340                 3345             


Pro Ser  Ser Ile Pro Gly Thr  Thr His Thr Ala Thr  Val Leu Thr 
    3350                 3355                 3360             


Thr Thr  Thr Thr Thr Val Ala  Thr Gly Ser Met Ala  Thr Pro Ser 
    3365                 3370                 3375             


Ser Ser  Thr Gln Thr Ser Gly  Thr Pro Pro Ser Leu  Thr Thr Thr 
    3380                 3385                 3390             


Ala Thr  Thr Ile Thr Ala Thr  Gly Ser Thr Thr Asn  Pro Ser Ser 
    3395                 3400                 3405             


Thr Pro  Gly Thr Thr Pro Ile  Pro Pro Val Leu Thr  Thr Thr Ala 
    3410                 3415                 3420             


Thr Thr  Pro Ala Ala Thr Ser  Ser Thr Val Thr Pro  Ser Ser Ala 
    3425                 3430                 3435             


Leu Gly  Thr Thr His Thr Pro  Pro Val Pro Asn Thr  Thr Ala Thr 
    3440                 3445                 3450             


Thr His  Gly Arg Ser Leu Pro  Pro Ser Ser Pro His  Thr Val Arg 
    3455                 3460                 3465             


Thr Ala  Trp Thr Ser Ala Thr  Ser Gly Ile Leu Gly  Thr Thr His 
    3470                 3475                 3480             


Ile Thr  Glu Pro Ser Thr Val  Thr Ser His Thr Pro  Ala Ala Thr 
    3485                 3490                 3495             


Thr Ser  Thr Thr Gln His Ser  Thr Pro Ala Leu Ser  Ser Pro His 
    3500                 3505                 3510             


Pro Ser  Ser Arg Thr Thr Glu  Ser Pro Pro Ser Pro  Gly Thr Thr 
    3515                 3520                 3525             


Thr Pro  Gly His Thr Arg Gly  Thr Ser Arg Thr Thr  Ala Thr Ala 
    3530                 3535                 3540             


Thr Pro  Ser Lys Thr Arg Thr  Ser Thr Leu Leu Pro  Ser Ser Pro 
    3545                 3550                 3555             


Thr Ser  Ala Pro Ile Thr Thr  Val Val Thr Thr Gly  Cys Glu Pro 
    3560                 3565                 3570             


Gln Cys  Ala Trp Ser Glu Trp  Leu Asp Tyr Ser Tyr  Pro Met Pro 
    3575                 3580                 3585             


Gly Pro  Ser Gly Gly Asp Phe  Asp Thr Tyr Ser Asn  Ile Arg Ala 
    3590                 3595                 3600             


Ala Gly  Gly Ala Val Cys Glu  Gln Pro Leu Gly Leu  Glu Cys Arg 
    3605                 3610                 3615             


Ala Gln  Ala Gln Pro Gly Val  Pro Leu Arg Glu Leu  Gly Gln Val 
    3620                 3625                 3630             


Val Glu  Cys Ser Leu Asp Phe  Gly Leu Val Cys Arg  Asn Arg Glu 
    3635                 3640                 3645             


Gln Val  Gly Lys Phe Lys Met  Cys Phe Asn Tyr Glu  Ile Arg Val 
    3650                 3655                 3660             


Phe Cys  Cys Asn Tyr Gly His  Cys Pro Ser Thr Pro  Ala Thr Ser 
    3665                 3670                 3675             


Ser Thr  Ala Thr Pro Ser Ser  Thr Pro Gly Thr Thr  Trp Ile Leu 
    3680                 3685                 3690             


Thr Lys  Leu Thr Thr Thr Ala  Thr Thr Thr Glu Ser  Thr Gly Ser 
    3695                 3700                 3705             


Thr Ala  Thr Pro Ser Ser Thr  Pro Gly Thr Thr Trp  Ile Leu Thr 
    3710                 3715                 3720             


Glu Pro  Ser Thr Thr Ala Thr  Val Thr Val Pro Thr  Gly Ser Thr 
    3725                 3730                 3735             


Ala Thr  Ala Ser Ser Thr Gln  Ala Thr Ala Gly Thr  Pro His Val 
    3740                 3745                 3750             


Ser Thr  Thr Ala Thr Thr Pro  Thr Val Thr Ser Ser  Lys Ala Thr 
    3755                 3760                 3765             


Pro Phe  Ser Ser Pro Gly Thr  Ala Thr Ala Leu Pro  Ala Leu Arg 
    3770                 3775                 3780             


Ser Thr  Ala Thr Thr Pro Thr  Ala Thr Ser Phe Thr  Ala Ile Pro 
    3785                 3790                 3795             


Ser Ser  Ser Leu Gly Thr Thr  Trp Thr Arg Leu Ser  Gln Thr Thr 
    3800                 3805                 3810             


Thr Pro  Thr Ala Thr Met Ser  Thr Ala Thr Pro Ser  Ser Thr Pro 
    3815                 3820                 3825             


Glu Thr  Ala His Thr Ser Thr  Val Leu Thr Thr Thr  Ala Thr Thr 
    3830                 3835                 3840             


Thr Arg  Ala Thr Gly Ser Val  Ala Thr Pro Ser Ser  Thr Pro Gly 
    3845                 3850                 3855             


Thr Ala  His Thr Thr Lys Val  Pro Thr Thr Thr Thr  Thr Gly Phe 
    3860                 3865                 3870             


Thr Val  Thr Pro Ser Ser Ser  Pro Gly Thr Ala Arg  Thr Pro Pro 
    3875                 3880                 3885             


Val Trp  Ile Ser Thr Thr Thr  Thr Pro Thr Thr Ser  Gly Ser Thr 
    3890                 3895                 3900             


Val Thr  Pro Ser Ser Val Pro  Gly Thr Thr His Thr  Pro Thr Val 
    3905                 3910                 3915             


Leu Thr  Thr Thr Thr Thr Thr  Val Ala Thr Gly Ser  Met Ala Thr 
    3920                 3925                 3930             


Pro Ser  Ser Ser Thr Gln Thr  Ser Gly Thr Pro Pro  Ser Leu Ile 
    3935                 3940                 3945             


Thr Thr  Ala Thr Thr Ile Thr  Ala Thr Gly Ser Thr  Thr Asn Pro 
    3950                 3955                 3960             


Ser Ser  Thr Pro Gly Thr Thr  Pro Ile Pro Pro Val  Leu Thr Thr 
    3965                 3970                 3975             


Thr Ala  Thr Thr Pro Ala Ala  Thr Ser Ser Thr Val  Thr Pro Ser 
    3980                 3985                 3990             


Ser Ala  Leu Gly Thr Thr His  Thr Pro Pro Val Pro  Asn Thr Thr 
    3995                 4000                 4005             


Ala Thr  Thr His Gly Arg Ser  Leu Ser Pro Ser Ser  Pro His Thr 
    4010                 4015                 4020             


Val Arg  Thr Ala Trp Thr Ser  Ala Thr Ser Gly Thr  Leu Gly Thr 
    4025                 4030                 4035             


Thr His  Ile Thr Glu Pro Ser  Thr Gly Thr Ser His  Thr Pro Ala 
    4040                 4045                 4050             


Ala Thr  Thr Gly Thr Thr Gln  His Ser Thr Pro Ala  Leu Ser Ser 
    4055                 4060                 4065             


Pro His  Pro Ser Ser Arg Thr  Thr Glu Ser Pro Pro  Ser Pro Gly 
    4070                 4075                 4080             


Thr Thr  Thr Pro Gly His Thr  Thr Ala Thr Ser Arg  Thr Thr Ala 
    4085                 4090                 4095             


Thr Ala  Thr Pro Ser Lys Thr  Arg Thr Ser Thr Leu  Leu Pro Ser 
    4100                 4105                 4110             


Ser Pro  Thr Ser Ala Pro Ile  Thr Thr Val Val Thr  Thr Gly Cys 
    4115                 4120                 4125             


Glu Pro  Gln Cys Ala Trp Ser  Glu Trp Leu Asp Tyr  Ser Tyr Pro 
    4130                 4135                 4140             


Met Pro  Gly Pro Ser Gly Gly  Asp Phe Asp Thr Tyr  Ser Asn Ile 
    4145                 4150                 4155             


Arg Ala  Ala Gly Gly Ala Val  Cys Glu Gln Pro Leu  Gly Leu Glu 
    4160                 4165                 4170             


Cys Arg  Ala Gln Ala Gln Pro  Gly Val Pro Leu Gly  Glu Leu Gly 
    4175                 4180                 4185             


Gln Val  Val Glu Cys Ser Leu  Asp Phe Gly Leu Val  Cys Arg Asn 
    4190                 4195                 4200             


Arg Glu  Gln Val Gly Lys Phe  Lys Met Cys Phe Asn  Tyr Glu Ile 
    4205                 4210                 4215             


Arg Val  Phe Cys Cys Asn Tyr  Gly His Cys Pro Ser  Thr Pro Ala 
    4220                 4225                 4230             


Thr Ser  Ser Thr Ala Met Pro  Ser Ser Thr Pro Gly  Thr Thr Trp 
    4235                 4240                 4245             


Ile Leu  Thr Glu Leu Thr Thr  Thr Ala Thr Thr Thr  Ala Ser Thr 
    4250                 4255                 4260             


Gly Ser  Thr Ala Thr Pro Ser  Ser Thr Pro Gly Thr  Ala Pro Pro 
    4265                 4270                 4275             


Pro Lys  Val Leu Thr Ser Pro  Ala Thr Thr Pro Thr  Ala Thr Ser 
    4280                 4285                 4290             


Ser Lys  Ala Thr Ser Ser Ser  Ser Pro Arg Thr Ala  Thr Thr Leu 
    4295                 4300                 4305             


Pro Val  Leu Thr Ser Thr Ala  Thr Lys Ser Thr Ala  Thr Ser Val 
    4310                 4315                 4320             


Thr Pro  Ile Pro Ser Ser Thr  Leu Gly Thr Thr Gly  Thr Leu Pro 
    4325                 4330                 4335             


Glu Gln  Thr Thr Thr Pro Val  Ala Thr Met Ser Thr  Ile His Pro 
    4340                 4345                 4350             


Ser Ser  Thr Pro Glu Thr Thr  His Thr Ser Thr Val  Leu Thr Thr 
    4355                 4360                 4365             


Lys Ala  Thr Thr Thr Arg Ala  Thr Ser Ser Thr Ser  Thr Pro Ser 
    4370                 4375                 4380             


Ser Thr  Pro Gly Thr Thr Trp  Ile Leu Thr Glu Leu  Thr Thr Ala 
    4385                 4390                 4395             


Ala Thr  Thr Thr Ala Ala Thr  Gly Pro Thr Ala Thr  Pro Ser Ser 
    4400                 4405                 4410             


Thr Pro  Gly Thr Thr Trp Ile  Leu Thr Glu Leu Thr  Thr Thr Ala 
    4415                 4420                 4425             


Thr Thr  Thr Ala Ser Thr Gly  Ser Thr Ala Thr Pro  Ser Ser Thr 
    4430                 4435                 4440             


Pro Gly  Thr Thr Trp Ile Leu  Thr Glu Pro Ser Thr  Thr Ala Thr 
    4445                 4450                 4455             


Val Thr  Val Pro Thr Gly Ser  Thr Ala Thr Ala Ser  Ser Thr Gln 
    4460                 4465                 4470             


Ala Thr  Ala Gly Thr Pro His  Val Ser Thr Thr Ala  Thr Thr Pro 
    4475                 4480                 4485             


Thr Val  Thr Ser Ser Lys Ala  Thr Pro Ser Ser Ser  Pro Gly Thr 
    4490                 4495                 4500             


Ala Thr  Ala Leu Pro Ala Leu  Arg Ser Thr Ala Thr  Thr Pro Thr 
    4505                 4510                 4515             


Ala Thr  Ser Phe Thr Ala Ile  Pro Ser Ser Ser Leu  Gly Thr Thr 
    4520                 4525                 4530             


Trp Thr  Arg Leu Ser Gln Thr  Thr Thr Pro Thr Ala  Thr Met Ser 
    4535                 4540                 4545             


Thr Ala  Thr Pro Ser Ser Thr  Pro Glu Thr Val His  Thr Ser Thr 
    4550                 4555                 4560             


Val Leu  Thr Ala Thr Ala Thr  Thr Thr Gly Ala Thr  Gly Ser Val 
    4565                 4570                 4575             


Ala Thr  Pro Ser Ser Thr Pro  Gly Thr Ala His Thr  Thr Lys Val 
    4580                 4585                 4590             


Pro Thr  Thr Thr Thr Thr Gly  Phe Thr Ala Thr Pro  Ser Ser Ser 
    4595                 4600                 4605             


Pro Gly  Thr Ala Leu Thr Pro  Pro Val Trp Ile Ser  Thr Thr Thr 
    4610                 4615                 4620             


Thr Pro  Thr Thr Thr Thr Pro  Thr Thr Ser Gly Ser  Thr Val Thr 
    4625                 4630                 4635             


Pro Ser  Ser Ile Pro Gly Thr  Thr His Thr Ala Arg  Val Leu Thr 
    4640                 4645                 4650             


Thr Thr  Thr Thr Thr Val Ala  Thr Gly Ser Met Ala  Thr Pro Ser 
    4655                 4660                 4665             


Ser Ser  Thr Gln Thr Ser Gly  Thr Pro Pro Ser Leu  Thr Thr Thr 
    4670                 4675                 4680             


Ala Thr  Thr Ile Thr Ala Thr  Gly Ser Thr Thr Asn  Pro Ser Ser 
    4685                 4690                 4695             


Thr Pro  Gly Thr Thr Pro Ile  Thr Pro Val Leu Thr  Ser Thr Ala 
    4700                 4705                 4710             


Thr Thr  Pro Ala Ala Thr Ser  Ser Lys Ala Thr Ser  Ser Ser Ser 
    4715                 4720                 4725             


Pro Arg  Thr Ala Thr Thr Leu  Pro Val Leu Thr Ser  Thr Ala Thr 
    4730                 4735                 4740             


Lys Ser  Thr Ala Thr Ser Phe  Thr Pro Ile Pro Ser  Ser Thr Leu 
    4745                 4750                 4755             


Trp Thr  Thr Trp Thr Val Pro  Ala Gln Thr Thr Thr  Pro Met Ser 
    4760                 4765                 4770             


Thr Met  Ser Thr Ile His Thr  Ser Ser Thr Pro Glu  Thr Thr His 
    4775                 4780                 4785             


Thr Ser  Thr Val Leu Thr Thr  Thr Ala Thr Met Thr  Arg Ala Thr 
    4790                 4795                 4800             


Asn Ser  Thr Ala Thr Pro Ser  Ser Thr Leu Gly Thr  Thr Arg Ile 
    4805                 4810                 4815             


Leu Thr  Glu Leu Thr Thr Thr  Ala Thr Thr Thr Ala  Ala Thr Gly 
    4820                 4825                 4830             


Ser Thr  Ala Thr Leu Ser Ser  Thr Pro Gly Thr Thr  Trp Ile Leu 
    4835                 4840                 4845             


Thr Glu  Pro Ser Thr Ile Ala  Thr Val Met Val Pro  Thr Gly Ser 
    4850                 4855                 4860             


Thr Ala  Thr Ala Ser Ser Thr  Leu Gly Thr Ala His  Thr Pro Lys 
    4865                 4870                 4875             


Val Val  Thr Thr Met Ala Thr  Met Pro Thr Ala Thr  Ala Ser Thr 
    4880                 4885                 4890             


Val Pro  Ser Ser Ser Thr Val  Gly Thr Thr Arg Thr  Pro Ala Val 
    4895                 4900                 4905             


Leu Pro  Ser Ser Leu Pro Thr  Phe Ser Val Ser Thr  Val Ser Ser 
    4910                 4915                 4920             


Ser Val  Leu Thr Thr Leu Arg  Pro Thr Gly Phe Pro  Ser Ser His 
    4925                 4930                 4935             


Phe Ser  Thr Pro Cys Phe Cys  Arg Ala Phe Gly Gln  Phe Phe Ser 
    4940                 4945                 4950             


Pro Gly  Glu Val Ile Tyr Asn  Lys Thr Asp Arg Ala  Gly Cys His 
    4955                 4960                 4965             


Phe Tyr  Ala Val Cys Asn Gln  His Cys Asp Ile Asp  Arg Phe Gln 
    4970                 4975                 4980             


Gly Ala  Cys Pro Thr Ser Pro  Pro Pro Val Ser Ser  Ala Pro Leu 
    4985                 4990                 4995             


Ser Ser  Pro Ser Pro Ala Pro  Gly Cys Asp Asn Ala  Ile Pro Leu 
    5000                 5005                 5010             


Arg Gln  Val Asn Glu Thr Trp  Thr Leu Glu Asn Cys  Thr Val Ala 
    5015                 5020                 5025             


Arg Cys  Val Gly Asp Asn Arg  Val Val Leu Leu Asp  Pro Lys Pro 
    5030                 5035                 5040             


Val Ala  Asn Val Thr Cys Val  Asn Lys His Leu Pro  Ile Lys Val 
    5045                 5050                 5055             


Ser Asp  Pro Ser Gln Pro Cys  Asp Phe His Tyr Glu  Cys Glu Cys 
    5060                 5065                 5070             


Ile Cys  Ser Met Trp Gly Gly  Ser His Tyr Ser Thr  Phe Asp Gly 
    5075                 5080                 5085             


Thr Ser  Tyr Thr Phe Arg Gly  Asn Cys Thr Tyr Val  Leu Met Arg 
    5090                 5095                 5100             


Glu Ile  His Ala Arg Phe Gly  Asn Leu Ser Leu Tyr  Leu Asp Asn 
    5105                 5110                 5115             


His Tyr  Cys Thr Ala Ser Ala  Thr Ala Ala Ala Ala  Arg Cys Pro 
    5120                 5125                 5130             


Arg Ala  Leu Ser Ile His Tyr  Lys Ser Met Asp Ile  Val Leu Thr 
    5135                 5140                 5145             


Val Thr  Met Val His Gly Lys  Glu Glu Gly Leu Ile  Leu Phe Asp 
    5150                 5155                 5160             


Gln Ile  Pro Val Ser Ser Gly  Phe Ser Lys Asn Gly  Val Leu Val 
    5165                 5170                 5175             


Ser Val  Leu Gly Thr Thr Thr  Met Arg Val Asp Ile  Pro Ala Leu 
    5180                 5185                 5190             


Gly Val  Ser Val Thr Phe Asn  Gly Gln Val Phe Gln  Ala Arg Leu 
    5195                 5200                 5205             


Pro Tyr  Ser Leu Phe His Asn  Asn Thr Glu Gly Gln  Cys Gly Thr 
    5210                 5215                 5220             


Cys Thr  Asn Asn Gln Arg Asp  Asp Cys Leu Gln Arg  Asp Gly Thr 
    5225                 5230                 5235             


Thr Ala  Ala Ser Cys Lys Asp  Met Ala Lys Thr Trp  Leu Val Pro 
    5240                 5245                 5250             


Asp Ser  Arg Lys Asp Gly Cys  Trp Ala Pro Thr Gly  Thr Pro Pro 
    5255                 5260                 5265             


Thr Ala  Ser Pro Ala Ala Pro  Val Ser Ser Thr Pro  Thr Pro Thr 
    5270                 5275                 5280             


Pro Cys  Pro Pro Gln Pro Leu  Cys Asp Leu Met Leu  Ser Gln Val 
    5285                 5290                 5295             


Phe Ala  Glu Cys His Asn Leu  Val Pro Pro Gly Pro  Phe Phe Asn 
    5300                 5305                 5310             


Ala Cys  Ile Ser Asp His Cys  Arg Gly Arg Leu Glu  Val Pro Cys 
    5315                 5320                 5325             


Gln Ser  Leu Glu Ala Tyr Ala  Glu Leu Cys Arg Ala  Arg Gly Val 
    5330                 5335                 5340             


Cys Ser  Asp Trp Arg Gly Ala  Thr Gly Gly Leu Cys  Asp Leu Thr 
    5345                 5350                 5355             


Cys Pro  Pro Thr Lys Val Tyr  Lys Pro Cys Gly Pro  Ile Gln Pro 
    5360                 5365                 5370             


Ala Thr  Cys Asn Ser Arg Asn  Gln Ser Pro Gln Leu  Glu Gly Met 
    5375                 5380                 5385             


Ala Glu  Gly Cys Phe Cys Pro  Glu Asp Gln Ile Leu  Phe Asn Ala 
    5390                 5395                 5400             


His Met  Gly Ile Cys Val Gln  Ala Cys Pro Cys Val  Gly Pro Asp 
    5405                 5410                 5415             


Gly Phe  Pro Lys Phe Pro Gly  Glu Arg Trp Val Ser  Asn Cys Gln 
    5420                 5425                 5430             


Ser Cys  Val Cys Asp Glu Gly  Ser Val Ser Val Gln  Cys Lys Pro 
    5435                 5440                 5445             


Leu Pro  Cys Asp Ala Gln Gly  Gln Pro Pro Pro Cys  Asn Arg Pro 
    5450                 5455                 5460             


Gly Phe  Val Thr Val Thr Arg  Pro Arg Ala Glu Asn  Pro Cys Cys 
    5465                 5470                 5475             


Pro Glu  Thr Val Cys Val Cys  Asn Thr Thr Thr Cys  Pro Gln Ser 
    5480                 5485                 5490             


Leu Pro  Val Cys Pro Pro Gly  Gln Glu Ser Ile Cys  Thr Gln Glu 
    5495                 5500                 5505             


Glu Gly  Asp Cys Cys Pro Thr  Phe Arg Cys Arg Pro  Gln Leu Cys 
    5510                 5515                 5520             


Ser Tyr  Asn Gly Thr Phe Tyr  Gly Val Gly Ala Thr  Phe Pro Gly 
    5525                 5530                 5535             


Ala Leu  Pro Cys His Met Cys  Thr Cys Leu Ser Gly  Asp Thr Gln 
    5540                 5545                 5550             


Asp Pro  Thr Val Gln Cys Gln  Glu Asp Ala Cys Asn  Asn Thr Thr 
    5555                 5560                 5565             


Cys Pro  Gln Gly Phe Glu Tyr  Lys Arg Val Ala Gly  Gln Cys Cys 
    5570                 5575                 5580             


Gly Glu  Cys Val Gln Thr Ala  Cys Leu Thr Pro Asp  Gly Gln Pro 
    5585                 5590                 5595             


Val Gln  Leu Asn Glu Thr Trp  Val Asn Ser His Val  Asp Asn Cys 
    5600                 5605                 5610             


Thr Val  Tyr Leu Cys Glu Ala  Glu Gly Gly Val His  Leu Leu Thr 
    5615                 5620                 5625             


Pro Gln  Pro Ala Ser Cys Pro  Asp Val Ser Ser Cys  Arg Gly Ser 
    5630                 5635                 5640             


Leu Arg  Lys Thr Gly Cys Cys  Tyr Ser Cys Glu Glu  Asp Ser Cys 
    5645                 5650                 5655             


Gln Val  Arg Ile Asn Thr Thr  Ile Leu Trp His Gln  Gly Cys Glu 
    5660                 5665                 5670             


Thr Glu  Val Asn Ile Thr Phe  Cys Glu Gly Ser Cys  Pro Gly Ala 
    5675                 5680                 5685             


Ser Lys  Tyr Ser Ala Glu Ala  Gln Ala Met Gln His  Gln Cys Thr 
    5690                 5695                 5700             


Cys Cys  Gln Glu Arg Arg Val  His Glu Glu Thr Val  Pro Leu His 
    5705                 5710                 5715             


Cys Pro  Asn Gly Ser Ala Ile  Leu His Thr Tyr Thr  His Val Asp 
    5720                 5725                 5730             


Glu Cys  Gly Cys Thr Pro Phe  Cys Val Pro Ala Pro  Met Ala Pro 
    5735                 5740                 5745             


Pro His  Thr Arg Gly Phe Pro  Ala Gln Glu Ala Thr  Ala Val 
    5750                 5755                 5760         


<210>  9107
<211>  154
<212>  PRT
<213>  Homo Sapiens

<400>  9107

Gln Pro Pro Pro Cys Asn Arg Pro Gly Phe Val Thr Val Thr Arg Pro 
1               5                   10                  15      


Arg Ala Glu Asn Pro Cys Cys Pro Glu Thr Val Cys Val Cys Asn Thr 
            20                  25                  30          


Thr Thr Cys Pro Gln Ser Leu Pro Val Cys Pro Pro Gly Gln Glu Ser 
        35                  40                  45              


Ile Cys Thr Gln Glu Glu Gly Asp Cys Cys Pro Thr Phe Arg Cys Arg 
    50                  55                  60                  


Pro Gln Leu Cys Ser Tyr Asn Gly Thr Phe Tyr Gly Val Gly Ala Thr 
65                  70                  75                  80  


Phe Pro Gly Ala Leu Pro Cys His Met Cys Thr Cys Leu Ser Gly Asp 
                85                  90                  95      


Thr Gln Asp Pro Thr Val Gln Cys Gln Glu Asp Ala Cys Asn Asn Thr 
            100                 105                 110         


Thr Cys Pro Gln Gly Phe Glu Tyr Lys Arg Val Ala Gly Gln Cys Cys 
        115                 120                 125             


Gly Glu Cys Val Gln Thr Ala Cys Leu Thr Pro Asp Gly Gln Pro Val 
    130                 135                 140                 


Gln Glu Ala Ala Thr Gly Lys Ala Ala Ala 
145                 150                 


<210>  9108
<211>  181
<212>  PRT
<213>  Homo Sapiens

<400>  9108

Met Asp Thr Ser Arg Thr Pro Ser Val Cys Arg Glu Thr Gly Gly Ala 
1               5                   10                  15      


Ala Leu Ser Arg Gly Glu Arg Arg Pro Gln Gly Arg Arg Gly Ser Pro 
            20                  25                  30          


Thr Pro Thr Ala Gly Pro Val His Thr Gly Leu Ala Asn Thr Ser Tyr 
        35                  40                  45              


Thr Ser Pro Gly Leu Gln Arg Leu Lys Asp Ser Pro Gln Thr Ala Pro 
    50                  55                  60                  


Asp Lys Gly Gln Cys Ser Thr Trp Gly Ala Gly His Phe Ser Thr Phe 
65                  70                  75                  80  


Asp His His Val Tyr Asp Phe Ser Gly Thr Cys Asn Tyr Ile Phe Ala 
                85                  90                  95      


Ala Thr Cys Lys Asp Ala Phe Pro Thr Phe Ser Val Gln Leu Arg Arg 
            100                 105                 110         


Gly Pro Asp Gly Ser Ile Ser Arg Ile Ile Val Glu Leu Gly Ala Ser 
        115                 120                 125             


Val Val Thr Val Ser Glu Ala Ile Ile Ser Val Lys Asp Ile Gly Val 
    130                 135                 140                 


Ile Ser Leu Pro Tyr Thr Ser Asn Gly Leu Gln Ile Thr Pro Phe Gly 
145                 150                 155                 160 


Gln Ser Val Arg Leu Val Ala Lys Gln Leu Glu Leu Glu Leu Glu Val 
                165                 170                 175     


Val Trp Gly Pro Asp 
            180     


<210>  9109
<211>  2439
<212>  PRT
<213>  Homo Sapiens

<400>  9109

Met Val Gln Arg Trp Leu Leu Leu Ser Cys Cys Gly Ala Leu Leu Ser 
1               5                   10                  15      


Ala Gly Leu Ala Asn Thr Ser Tyr Thr Ser Pro Gly Leu Gln Arg Leu 
            20                  25                  30          


Lys Asp Ser Pro Gln Thr Ala Pro Asp Lys Gly Gln Cys Ser Thr Trp 
        35                  40                  45              


Gly Ala Gly His Phe Ser Thr Phe Asp His His Val Tyr Asp Phe Ser 
    50                  55                  60                  


Gly Thr Cys Asn Tyr Ile Phe Ala Ala Thr Cys Lys Asp Ala Phe Pro 
65                  70                  75                  80  


Thr Phe Ser Val Gln Leu Arg Arg Gly Pro Asp Gly Ser Ile Ser Arg 
                85                  90                  95      


Ile Ile Val Glu Leu Gly Ala Ser Val Val Thr Val Ser Glu Ala Ile 
            100                 105                 110         


Ile Ser Val Lys Asp Ile Gly Val Ile Ser Leu Pro Tyr Thr Ser Asn 
        115                 120                 125             


Gly Leu Gln Ile Thr Pro Phe Gly Gln Ser Val Arg Leu Val Ala Lys 
    130                 135                 140                 


Gln Leu Glu Leu Glu Leu Glu Val Val Trp Gly Pro Asp Ser His Leu 
145                 150                 155                 160 


Met Val Leu Val Glu Arg Lys Tyr Met Gly Gln Met Cys Gly Leu Cys 
                165                 170                 175     


Gly Asn Phe Asp Gly Lys Val Thr Asn Glu Phe Val Ser Glu Glu Gly 
            180                 185                 190         


Lys Phe Leu Glu Pro His Lys Phe Ala Ala Leu Gln Lys Leu Asp Asp 
        195                 200                 205             


Pro Gly Glu Ile Cys Thr Phe Gln Asp Ile Pro Ser Thr His Val Arg 
    210                 215                 220                 


Gln Ala Gln His Ala Arg Ile Cys Thr Gln Leu Leu Thr Leu Val Ala 
225                 230                 235                 240 


Pro Glu Cys Ser Val Ser Lys Glu Pro Phe Val Leu Ser Cys Gln Ala 
                245                 250                 255     


Asp Val Ala Ala Ala Pro Gln Pro Gly Pro Gln Asn Ser Ser Cys Ala 
            260                 265                 270         


Thr Leu Ser Glu Tyr Ser Arg Gln Cys Ser Met Val Gly Gln Pro Val 
        275                 280                 285             


Arg Arg Trp Arg Ser Pro Gly Leu Cys Ser Val Gly Gln Cys Pro Ala 
    290                 295                 300                 


Asn Gln Val Tyr Gln Glu Cys Gly Ser Ala Cys Val Lys Thr Cys Ser 
305                 310                 315                 320 


Asn Pro Gln His Ser Cys Ser Ser Ser Cys Thr Phe Gly Cys Phe Cys 
                325                 330                 335     


Pro Glu Gly Thr Val Leu Asn Asp Leu Ser Asn Asn His Thr Cys Val 
            340                 345                 350         


Pro Val Thr Gln Cys Pro Cys Val Leu His Gly Ala Met Tyr Ala Pro 
        355                 360                 365             


Gly Glu Val Thr Ile Ala Ala Cys Gln Thr Cys Arg Cys Thr Leu Gly 
    370                 375                 380                 


Arg Trp Val Cys Thr Glu Arg Pro Cys Pro Gly His Cys Ser Leu Glu 
385                 390                 395                 400 


Gly Gly Ser Phe Val Thr Thr Phe Asp Ala Arg Pro Tyr Arg Phe His 
                405                 410                 415     


Gly Thr Cys Thr Tyr Ile Leu Leu Gln Ser Pro Gln Leu Pro Glu Asp 
            420                 425                 430         


Gly Ala Leu Met Ala Val Tyr Asp Lys Ser Gly Val Ser His Ser Glu 
        435                 440                 445             


Thr Ser Leu Val Ala Val Val Tyr Leu Ser Arg Gln Asp Lys Ile Val 
    450                 455                 460                 


Ile Ser Gln Asp Glu Val Val Thr Asn Asn Gly Glu Ala Lys Trp Leu 
465                 470                 475                 480 


Pro Tyr Lys Thr Arg Asn Ile Thr Val Phe Arg Gln Thr Ser Thr His 
                485                 490                 495     


Leu Gln Met Ala Thr Ser Phe Gly Leu Glu Leu Val Val Gln Leu Arg 
            500                 505                 510         


Pro Ile Phe Gln Ala Tyr Val Thr Val Gly Pro Gln Phe Arg Gly Gln 
        515                 520                 525             


Thr Arg Gly Leu Cys Gly Asn Phe Asn Gly Asp Thr Thr Asp Asp Phe 
    530                 535                 540                 


Thr Thr Ser Met Gly Ile Ala Glu Gly Thr Ala Ser Leu Phe Val Asp 
545                 550                 555                 560 


Ser Trp Arg Ala Gly Asn Cys Pro Ala Ala Leu Glu Arg Glu Thr Asp 
                565                 570                 575     


Pro Cys Ser Met Ser Gln Leu Asn Lys Val Cys Ala Glu Thr His Cys 
            580                 585                 590         


Ser Met Leu Leu Arg Thr Gly Thr Val Phe Glu Arg Cys His Ala Thr 
        595                 600                 605             


Val Asn Pro Ala Pro Phe Tyr Lys Arg Cys Val Tyr Gln Ala Cys Asn 
    610                 615                 620                 


Tyr Glu Glu Thr Phe Pro His Ile Cys Ala Ala Leu Gly Asp Tyr Val 
625                 630                 635                 640 


His Ala Cys Ser Leu Arg Gly Val Leu Leu Trp Gly Trp Arg Ser Ser 
                645                 650                 655     


Val Asp Asn Cys Thr Ile Pro Cys Thr Gly Asn Thr Thr Phe Ser Tyr 
            660                 665                 670         


Asn Ser Gln Ala Cys Glu Arg Thr Cys Leu Ser Leu Ser Asp Arg Ala 
        675                 680                 685             


Thr Glu Cys His His Ser Ala Val Pro Val Asp Gly Cys Asn Cys Pro 
    690                 695                 700                 


Asp Gly Thr Tyr Leu Asn Gln Lys Gly Glu Cys Val Arg Lys Ala Gln 
705                 710                 715                 720 


Cys Pro Cys Ile Leu Glu Gly Tyr Lys Phe Ile Leu Ala Glu Gln Ser 
                725                 730                 735     


Thr Val Ile Asn Gly Ile Thr Cys His Cys Ile Asn Gly Arg Leu Ser 
            740                 745                 750         


Cys Pro Gln Arg Pro Gln Met Phe Leu Ala Ser Cys Gln Ala Pro Lys 
        755                 760                 765             


Thr Phe Lys Ser Cys Ser Gln Ser Ser Glu Asn Lys Phe Gly Ala Ala 
    770                 775                 780                 


Cys Ala Pro Thr Cys Gln Met Leu Ala Thr Gly Val Ala Cys Val Pro 
785                 790                 795                 800 


Thr Lys Cys Glu Pro Gly Cys Val Cys Ala Glu Gly Leu Tyr Glu Asn 
                805                 810                 815     


Ala Asp Gly Gln Cys Val Pro Pro Glu Glu Cys Pro Cys Glu Phe Ser 
            820                 825                 830         


Gly Val Ser Tyr Pro Gly Gly Ala Glu Leu His Thr Asp Cys Arg Thr 
        835                 840                 845             


Cys Ser Cys Ser Arg Gly Arg Trp Ala Cys Gln Gln Gly Thr His Cys 
    850                 855                 860                 


Pro Ser Thr Cys Thr Leu Tyr Gly Glu Gly His Val Ile Thr Phe Asp 
865                 870                 875                 880 


Gly Gln Arg Phe Val Phe Asp Gly Asn Cys Glu Tyr Ile Leu Ala Thr 
                885                 890                 895     


Asp Val Cys Gly Val Asn Asp Ser Gln Pro Thr Phe Lys Ile Leu Thr 
            900                 905                 910         


Glu Asn Val Ile Cys Gly Asn Ser Gly Val Thr Cys Ser Arg Ala Ile 
        915                 920                 925             


Lys Ile Phe Leu Gly Gly Leu Ser Val Val Leu Ala Asp Arg Asn Tyr 
    930                 935                 940                 


Thr Val Thr Gly Glu Glu Pro His Val Gln Leu Gly Val Thr Pro Gly 
945                 950                 955                 960 


Ala Leu Ser Leu Val Val Asp Ile Ser Ile Pro Gly Arg Tyr Asn Leu 
                965                 970                 975     


Thr Leu Ile Trp Asn Arg His Met Thr Ile Leu Ile Arg Ile Ala Arg 
            980                 985                 990         


Ala Ser Gln Asp Pro Leu Cys Gly  Leu Cys Gly Asn Phe  Asn Gly Asn 
        995                 1000                 1005             


Met Lys  Asp Asp Phe Glu Thr  Arg Ser Arg Tyr Val  Ala Ser Ser 
    1010                 1015                 1020             


Glu Leu  Glu Leu Val Asn Ser  Trp Lys Glu Ser Pro  Leu Cys Gly 
    1025                 1030                 1035             


Asp Val  Ser Phe Val Thr Asp  Pro Cys Ser Leu Asn  Ala Phe Arg 
    1040                 1045                 1050             


Arg Ser  Trp Ala Glu Arg Lys  Cys Ser Val Ile Asn  Ser Gln Thr 
    1055                 1060                 1065             


Phe Ala  Thr Cys His Ser Lys  Val Tyr His Leu Pro  Tyr Tyr Glu 
    1070                 1075                 1080             


Ala Cys  Val Arg Asp Ala Cys  Gly Cys Asp Ser Gly  Gly Asp Cys 
    1085                 1090                 1095             


Glu Cys  Leu Cys Asp Ala Val  Ala Ala Tyr Ala Gln  Ala Cys Leu 
    1100                 1105                 1110             


Asp Lys  Gly Val Cys Val Asp  Trp Arg Thr Pro Ala  Phe Cys Pro 
    1115                 1120                 1125             


Ile Tyr  Cys Gly Phe Tyr Asn  Thr His Thr Gln Asp  Gly His Gly 
    1130                 1135                 1140             


Glu Tyr  Gln Tyr Thr Gln Glu  Ala Asn Cys Thr Trp  His Tyr Gln 
    1145                 1150                 1155             


Pro Cys  Leu Cys Pro Ser Gln  Pro Gln Ser Val Pro  Gly Ser Asn 
    1160                 1165                 1170             


Ile Glu  Gly Cys Tyr Asn Cys  Ser Gln Asp Glu Tyr  Phe Asp His 
    1175                 1180                 1185             


Glu Glu  Gly Val Cys Val Pro  Cys Met Pro Pro Thr  Thr Pro Gln 
    1190                 1195                 1200             


Pro Pro  Thr Thr Pro Gln Leu  Pro Thr Thr Gly Ser  Arg Pro Thr 
    1205                 1210                 1215             


Gln Val  Trp Pro Met Thr Gly  Thr Ser Thr Thr Ile  Gly Leu Leu 
    1220                 1225                 1230             


Ser Ser  Thr Gly Pro Ser Pro  Ser Ser Asn His Thr  Pro Ala Ser 
    1235                 1240                 1245             


Pro Thr  Gln Thr Pro Leu Leu  Pro Ala Thr Leu Thr  Ser Ser Lys 
    1250                 1255                 1260             


Pro Thr  Ala Ser Ser Gly Glu  Pro Pro Arg Pro Thr  Thr Ala Val 
    1265                 1270                 1275             


Thr Pro  Gln Ala Thr Ser Gly  Leu Pro Pro Thr Ala  Thr Leu Arg 
    1280                 1285                 1290             


Ser Thr  Ala Thr Lys Pro Thr  Val Thr Gln Ala Thr  Thr Arg Ala 
    1295                 1300                 1305             


Thr Ala  Ser Thr Ala Ser Pro  Ala Thr Thr Ser Thr  Ala Gln Ser 
    1310                 1315                 1320             


Thr Thr  Arg Thr Thr Met Thr  Leu Pro Thr Pro Ala  Thr Ser Gly 
    1325                 1330                 1335             


Thr Ser  Pro Thr Leu Pro Lys  Ser Thr Asn Gln Glu  Leu Pro Gly 
    1340                 1345                 1350             


Thr Thr  Ala Thr Gln Thr Thr  Gly Pro Arg Pro Thr  Pro Ala Ser 
    1355                 1360                 1365             


Thr Thr  Gly Pro Thr Thr Pro  Gln Pro Gly Gln Pro  Thr Arg Pro 
    1370                 1375                 1380             


Thr Ala  Thr Glu Thr Thr Gln  Thr Arg Thr Thr Thr  Glu Tyr Thr 
    1385                 1390                 1395             


Thr Pro  Gln Thr Pro His Thr  Thr His Ser Pro Pro  Thr Ala Gly 
    1400                 1405                 1410             


Ser Pro  Val Pro Ser Thr Gly  Pro Val Thr Ala Thr  Ser Phe His 
    1415                 1420                 1425             


Ala Thr  Thr Thr Tyr Pro Thr  Pro Ser His Pro Glu  Thr Thr Leu 
    1430                 1435                 1440             


Pro Thr  His Val Pro Pro Phe  Ser Thr Ser Leu Val  Thr Pro Ser 
    1445                 1450                 1455             


Thr His  Thr Val Ile Thr Pro  Thr His Ala Gln Met  Ala Thr Ser 
    1460                 1465                 1470             


Ala Ser  Asn His Ser Ala Pro  Thr Gly Thr Ile Pro  Pro Pro Thr 
    1475                 1480                 1485             


Thr Leu  Lys Ala Thr Gly Ser  Thr His Thr Ala Pro  Pro Ile Thr 
    1490                 1495                 1500             


Pro Thr  Thr Ser Gly Thr Ser  Gln Ala His Ser Ser  Phe Ser Thr 
    1505                 1510                 1515             


Asn Lys  Thr Pro Thr Ser Leu  His Ser His Thr Ser  Ser Thr His 
    1520                 1525                 1530             


His Pro  Glu Val Thr Pro Thr  Ser Thr Thr Thr Ile  Thr Pro Asn 
    1535                 1540                 1545             


Pro Thr  Ser Thr Arg Thr Arg  Thr Pro Val Ala His  Thr Asn Ser 
    1550                 1555                 1560             


Ala Thr  Ser Ser Arg Pro Pro  Pro Pro Phe Thr Thr  His Ser Pro 
    1565                 1570                 1575             


Pro Thr  Gly Ser Ser Pro Phe  Ser Ser Thr Gly Pro  Met Thr Ala 
    1580                 1585                 1590             


Thr Ser  Phe Lys Thr Thr Thr  Thr Tyr Pro Thr Pro  Ser His Pro 
    1595                 1600                 1605             


Gln Thr  Thr Leu Pro Thr His  Val Pro Pro Phe Ser  Thr Ser Leu 
    1610                 1615                 1620             


Val Thr  Pro Ser Thr His Thr  Val Ile Thr Pro Thr  His Ala Gln 
    1625                 1630                 1635             


Met Ala  Thr Ser Ala Ser Ile  His Ser Met Pro Thr  Gly Thr Ile 
    1640                 1645                 1650             


Pro Pro  Pro Thr Thr Leu Lys  Ala Thr Gly Ser Thr  His Thr Ala 
    1655                 1660                 1665             


Pro Thr  Met Thr Leu Thr Thr  Ser Gly Thr Ser Gln  Ala Leu Ser 
    1670                 1675                 1680             


Ser Leu  Asn Thr Ala Lys Thr  Ser Thr Ser Leu His  Ser His Thr 
    1685                 1690                 1695             


Ser Ser  Thr His His Ala Glu  Ala Thr Ser Thr Ser  Thr Thr Asn 
    1700                 1705                 1710             


Ile Thr  Pro Asn Pro Thr Ser  Thr Gly Thr Pro Pro  Met Thr Val 
    1715                 1720                 1725             


Thr Thr  Ser Gly Thr Ser Gln  Ser Arg Ser Ser Phe  Ser Thr Ala 
    1730                 1735                 1740             


Lys Thr  Ser Thr Ser Leu His  Ser His Thr Ser Ser  Thr His His 
    1745                 1750                 1755             


Pro Glu  Val Thr Ser Thr Ser  Thr Thr Ser Ile Thr  Pro Asn His 
    1760                 1765                 1770             


Thr Ser  Thr Gly Thr Arg Thr  Pro Val Ala His Thr  Thr Ser Ala 
    1775                 1780                 1785             


Thr Ser  Ser Arg Leu Pro Thr  Pro Phe Thr Thr His  Ser Pro Pro 
    1790                 1795                 1800             


Thr Gly  Thr Thr Pro Ile Ser  Ser Thr Gly Pro Val  Thr Ala Thr 
    1805                 1810                 1815             


Ser Phe  Gln Thr Thr Thr Thr  Tyr Pro Thr Pro Ser  His Pro His 
    1820                 1825                 1830             


Thr Thr  Leu Pro Thr His Val  Pro Ser Phe Ser Thr  Ser Leu Val 
    1835                 1840                 1845             


Thr Pro  Ser Thr His Thr Val  Ile Ile Pro Thr His  Thr Gln Met 
    1850                 1855                 1860             


Ala Thr  Ser Ala Ser Ile His  Ser Met Pro Thr Gly  Thr Ile Pro 
    1865                 1870                 1875             


Pro Pro  Thr Thr Ile Lys Ala  Thr Gly Ser Thr His  Thr Ala Pro 
    1880                 1885                 1890             


Pro Met  Thr Pro Thr Thr Ser  Gly Thr Ser Gln Ser  Pro Ser Ser 
    1895                 1900                 1905             


Phe Ser  Thr Ala Lys Thr Ser  Thr Ser Leu Pro Tyr  His Thr Ser 
    1910                 1915                 1920             


Ser Thr  His His Pro Glu Val  Thr Pro Thr Ser Thr  Thr Asn Ile 
    1925                 1930                 1935             


Thr Pro  Lys His Thr Ser Thr  Gly Thr Arg Thr Pro  Val Ala His 
    1940                 1945                 1950             


Thr Thr  Ser Ala Ser Ser Ser  Arg Leu Pro Thr Pro  Phe Thr Thr 
    1955                 1960                 1965             


His Ser  Pro Pro Thr Gly Ser  Ser Pro Phe Ser Ser  Thr Gly Pro 
    1970                 1975                 1980             


Met Thr  Ala Thr Ser Phe Gln  Thr Thr Thr Thr Tyr  Pro Thr Pro 
    1985                 1990                 1995             


Ser His  Pro Gln Thr Thr Leu  Pro Thr His Val Pro  Pro Phe Ser 
    2000                 2005                 2010             


Thr Ser  Leu Val Thr Pro Ser  Thr His Thr Val Ile  Ile Thr Thr 
    2015                 2020                 2025             


His Thr  Gln Met Ala Thr Ser  Ala Ser Ile His Ser  Thr Pro Thr 
    2030                 2035                 2040             


Gly Thr  Val Pro Pro Pro Thr  Thr Leu Lys Ala Thr  Gly Ser Thr 
    2045                 2050                 2055             


His Thr  Ala Pro Pro Met Thr  Val Thr Thr Ser Gly  Thr Ser Gln 
    2060                 2065                 2070             


Thr His  Ser Ser Phe Ser Thr  Ala Thr Ala Ser Ser  Ser Phe Ile 
    2075                 2080                 2085             


Ser Ser  Ser Ser Trp Leu Pro  Gln Asn Ser Ser Ser  Arg Pro Pro 
    2090                 2095                 2100             


Ser Ser  Pro Ile Thr Thr Gln  Leu Pro His Leu Ser  Ser Ala Thr 
    2105                 2110                 2115             


Thr Pro  Val Ser Thr Thr Asn  Gln Leu Ser Ser Ser  Phe Ser Pro 
    2120                 2125                 2130             


Ser Pro  Ser Ala Pro Ser Thr  Val Ser Ser Tyr Val  Pro Ser Ser 
    2135                 2140                 2145             


His Ser  Ser Pro Gln Thr Ser  Ser Pro Ser Val Gly  Thr Ser Ser 
    2150                 2155                 2160             


Ser Phe  Val Ser Ala Pro Val  His Ser Thr Thr Leu  Ser Ser Gly 
    2165                 2170                 2175             


Ser His  Ser Ser Leu Ser Thr  His Pro Thr Thr Ala  Ser Val Ser 
    2180                 2185                 2190             


Ala Ser  Pro Leu Phe Pro Ser  Ser Pro Ala Ala Ser  Thr Thr Ile 
    2195                 2200                 2205             


Arg Ala  Thr Leu Pro His Thr  Ile Ser Ser Pro Phe  Thr Leu Ser 
    2210                 2215                 2220             


Ala Leu  Leu Pro Ile Ser Thr  Val Thr Val Ser Pro  Thr Pro Ser 
    2225                 2230                 2235             


Ser His  Leu Ala Ser Ser Thr  Ile Ala Phe Pro Ser  Thr Pro Arg 
    2240                 2245                 2250             


Thr Thr  Ala Ser Thr His Thr  Ala Pro Ala Phe Ser  Ser Gln Ser 
    2255                 2260                 2265             


Thr Thr  Ser Arg Ser Thr Ser  Leu Thr Thr Arg Val  Pro Thr Ser 
    2270                 2275                 2280             


Gly Phe  Val Ser Leu Thr Ser  Gly Val Thr Gly Ile  Pro Thr Ser 
    2285                 2290                 2295             


Pro Val  Thr Asn Leu Thr Thr  Arg His Pro Gly Pro  Thr Leu Ser 
    2300                 2305                 2310             


Pro Thr  Thr Arg Phe Leu Thr  Ser Ser Leu Thr Ala  His Gly Ser 
    2315                 2320                 2325             


Thr Pro  Ala Ser Ala Pro Val  Ser Ser Leu Gly Thr  Pro Thr Pro 
    2330                 2335                 2340             


Thr Ser  Pro Gly Val Cys Ser  Val Arg Glu Gln Gln  Glu Glu Ile 
    2345                 2350                 2355             


Thr Phe  Lys Gly Cys Met Ala  Asn Val Thr Val Thr  Arg Cys Glu 
    2360                 2365                 2370             


Gly Ala  Cys Ile Ser Ala Ala  Ser Phe Asn Ile Ile  Thr Gln Gln 
    2375                 2380                 2385             


Val Asp  Ala Arg Cys Ser Cys  Cys Arg Pro Leu His  Ser Tyr Glu 
    2390                 2395                 2400             


Gln Gln  Leu Glu Leu Pro Cys  Pro Asp Pro Ser Thr  Pro Gly Arg 
    2405                 2410                 2415             


Arg Leu  Val Leu Thr Leu Gln  Val Phe Ser His Cys  Val Cys Ser 
    2420                 2425                 2430             


Ser Val  Ala Cys Gly Asp 
    2435                 


<210>  9110
<211>  115
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9110

Xaa Pro Pro Thr Thr Pro Gln Pro Pro Thr Thr Pro Gln Leu Pro Thr 
1               5                   10                  15      


Thr Gly Ser Arg Pro Thr Gln Val Trp Pro Met Thr Gly Thr Ser Thr 
            20                  25                  30          


Thr Ile Gly Leu Leu Ser Ser Thr Gly Pro Ser Pro Ser Ser Asn His 
        35                  40                  45              


Thr Pro Ala Ser Pro Thr Gln Thr Pro Leu Leu Pro Ala Thr Leu Thr 
    50                  55                  60                  


Ser Ser Lys Pro Thr Ala Ser Ser Gly Gly Lys Glu Pro Pro Ala Glu 
65                  70                  75                  80  


Pro Met Glu Arg Ala Ala Ala Gly Gly Pro Arg Tyr Thr Ser Gly Val 
                85                  90                  95      


Gly Leu Gly Met Ala Leu Leu Pro Gly Ser His Leu Pro Leu Ser Arg 
            100                 105                 110         


Phe Pro Ala 
        115 


<210>  9111
<211>  219
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9111

Xaa Ser Ser Pro Phe Thr Leu Ser Ala Leu Leu Pro Ile Ser Thr Val 
1               5                   10                  15      


Thr Val Ser Pro Thr Pro Ser Ser His Leu Ala Ser Ser Thr Ile Ala 
            20                  25                  30          


Phe Pro Ser Thr Pro Arg Thr Thr Ala Ser Thr His Thr Ala Pro Ala 
        35                  40                  45              


Phe Ser Ser Gln Ser Thr Thr Ser Arg Ser Thr Ser Leu Thr Thr Arg 
    50                  55                  60                  


Val Pro Thr Ser Gly Phe Val Ser Leu Thr Ser Gly Val Thr Gly Ile 
65                  70                  75                  80  


Pro Thr Ser Pro Val Thr Asn Leu Thr Thr Arg His Pro Gly Pro Thr 
                85                  90                  95      


Leu Ser Pro Thr Thr Arg Phe Leu Thr Ser Ser Leu Thr Ala His Gly 
            100                 105                 110         


Ser Thr Pro Ala Ser Ala Pro Val Ser Ser Leu Gly Thr Pro Thr Pro 
        115                 120                 125             


Thr Ser Pro Gly Glu Ser Thr Gly Gly Arg Pro Ala Pro Arg Pro Pro 
    130                 135                 140                 


Arg Cys Ser Gln Pro His Pro Arg Glu Val Arg Ala Pro His Pro Gly 
145                 150                 155                 160 


Ala Cys Cys Pro Ile Ser Phe Asn Ile Ile Thr Gln Gln Val Asp Ala 
                165                 170                 175     


Arg Cys Ser Cys Cys Arg Pro Leu His Ser Tyr Glu Gln Gln Leu Glu 
            180                 185                 190         


Leu Pro Cys Pro Asp Pro Ser Thr Pro Gly Arg Arg Leu Val Leu Thr 
        195                 200                 205             


Leu Gln Val Phe Ser His Cys Val Cys Ser Ser 
    210                 215                 


<210>  9112
<211>  136
<212>  PRT
<213>  Homo Sapiens

<400>  9112

Met Lys Thr Leu Pro Leu Phe Val Cys Ile Cys Ala Leu Ser Ala Cys 
1               5                   10                  15      


Phe Ser Phe Ser Glu Gly Arg Glu Arg Asp His Glu Leu Arg His Arg 
            20                  25                  30          


Arg His His His Gln Ser Pro Lys Ser His Phe Glu Leu Pro His Tyr 
        35                  40                  45              


Pro Gly Leu Leu Ala His Gln Lys Pro Phe Ile Arg Lys Ser Tyr Lys 
    50                  55                  60                  


Cys Leu His Lys Arg Cys Arg Pro Lys Leu Pro Pro Ser Pro Asn Asn 
65                  70                  75                  80  


Pro Pro Lys Phe Pro Asn Pro His Gln Pro Pro Lys His Pro Asp Lys 
                85                  90                  95      


Asn Ser Ser Val Val Asn Pro Thr Leu Val Ala Thr Thr Gln Ile Pro 
            100                 105                 110         


Ser Val Thr Phe Pro Ser Ala Ser Thr Lys Ile Thr Thr Leu Pro Asn 
        115                 120                 125             


Val Thr Phe Leu Pro Gln Asn Ala 
    130                 135     


<210>  9113
<211>  377
<212>  PRT
<213>  Homo Sapiens

<400>  9113

Met Lys Thr Leu Pro Leu Phe Val Cys Ile Cys Ala Leu Ser Ala Cys 
1               5                   10                  15      


Phe Ser Phe Ser Glu Gly Arg Glu Arg Asp His Glu Leu Arg His Arg 
            20                  25                  30          


Arg His His His Gln Ser Pro Lys Ser His Phe Glu Leu Pro His Tyr 
        35                  40                  45              


Pro Gly Leu Leu Ala His Gln Lys Pro Phe Ile Arg Lys Ser Tyr Lys 
    50                  55                  60                  


Cys Leu His Lys Arg Cys Arg Pro Lys Leu Pro Pro Ser Pro Asn Asn 
65                  70                  75                  80  


Pro Pro Lys Phe Pro Asn Pro His Gln Pro Pro Lys His Pro Asp Lys 
                85                  90                  95      


Asn Ser Ser Val Val Asn Pro Thr Leu Val Ala Thr Thr Gln Ile Pro 
            100                 105                 110         


Ser Val Thr Phe Pro Ser Ala Ser Thr Lys Ile Thr Thr Leu Pro Asn 
        115                 120                 125             


Val Thr Phe Leu Pro Gln Asn Ala Thr Thr Ile Ser Ser Arg Glu Asn 
    130                 135                 140                 


Val Asn Thr Ser Ser Ser Val Ala Thr Leu Ala Pro Val Asn Ser Pro 
145                 150                 155                 160 


Ala Pro Gln Asp Thr Thr Ala Ala Pro Pro Thr Pro Ser Ala Thr Thr 
                165                 170                 175     


Pro Ala Pro Pro Ser Ser Ser Ala Pro Pro Glu Thr Thr Ala Ala Pro 
            180                 185                 190         


Pro Thr Pro Ser Ala Thr Thr Gln Ala Pro Pro Ser Ser Ser Ala Pro 
        195                 200                 205             


Pro Glu Thr Thr Ala Ala Pro Pro Thr Pro Pro Ala Thr Thr Pro Ala 
    210                 215                 220                 


Pro Pro Ser Ser Ser Ala Pro Pro Glu Thr Thr Ala Ala Pro Pro Thr 
225                 230                 235                 240 


Pro Ser Ala Thr Thr Pro Ala Pro Leu Ser Ser Ser Ala Pro Pro Glu 
                245                 250                 255     


Thr Thr Ala Val Pro Pro Thr Pro Ser Ala Thr Thr Leu Asp Pro Ser 
            260                 265                 270         


Ser Ala Ser Ala Pro Pro Glu Thr Thr Ala Ala Pro Pro Thr Pro Ser 
        275                 280                 285             


Ala Thr Thr Pro Ala Pro Pro Ser Ser Pro Ala Pro Gln Glu Thr Thr 
    290                 295                 300                 


Ala Ala Pro Ile Thr Thr Pro Asn Ser Ser Pro Thr Thr Leu Ala Pro 
305                 310                 315                 320 


Asp Thr Ser Glu Thr Ser Ala Ala Pro Thr His Gln Thr Thr Thr Ser 
                325                 330                 335     


Val Thr Thr Gln Thr Thr Thr Thr Lys Gln Pro Thr Ser Ala Pro Gly 
            340                 345                 350         


Gln Asn Lys Ile Ser Arg Phe Leu Leu Tyr Met Lys Asn Leu Leu Asn 
        355                 360                 365             


Arg Ile Ile Asp Asp Met Val Glu Gln 
    370                 375         


<210>  9114
<211>  377
<212>  PRT
<213>  Homo Sapiens

<400>  9114

Met Lys Thr Leu Pro Leu Phe Val Cys Ile Cys Ala Leu Ser Ala Cys 
1               5                   10                  15      


Phe Ser Phe Ser Glu Gly Arg Glu Arg Asp His Glu Leu Arg His Arg 
            20                  25                  30          


Arg His His His Gln Ser Pro Lys Ser His Phe Glu Leu Pro His Tyr 
        35                  40                  45              


Pro Gly Leu Leu Ala His Gln Lys Pro Phe Ile Arg Lys Ser Tyr Lys 
    50                  55                  60                  


Cys Leu His Lys Arg Cys Arg Pro Lys Leu Pro Pro Ser Pro Asn Asn 
65                  70                  75                  80  


Pro Pro Lys Phe Pro Asn Pro His Gln Pro Pro Lys His Pro Asp Lys 
                85                  90                  95      


Asn Ser Ser Val Val Asn Pro Thr Leu Val Ala Thr Thr Gln Ile Pro 
            100                 105                 110         


Ser Val Thr Phe Pro Ser Ala Ser Thr Lys Ile Thr Thr Leu Pro Asn 
        115                 120                 125             


Val Thr Phe Leu Pro Gln Asn Ala Thr Thr Ile Ser Ser Arg Glu Asn 
    130                 135                 140                 


Val Asn Thr Ser Ser Ser Val Ala Thr Leu Ala Pro Val Asn Ser Pro 
145                 150                 155                 160 


Ala Pro Gln Asp Thr Thr Ala Ala Pro Pro Thr Pro Ser Ala Thr Thr 
                165                 170                 175     


Pro Ala Pro Pro Ser Ser Ser Ala Pro Pro Glu Thr Thr Ala Ala Pro 
            180                 185                 190         


Pro Thr Pro Ser Ala Thr Thr Gln Ala Pro Pro Ser Ser Ser Ala Pro 
        195                 200                 205             


Pro Glu Thr Thr Ala Ala Pro Pro Thr Pro Pro Ala Thr Thr Pro Ala 
    210                 215                 220                 


Pro Pro Ser Ser Ser Ala Pro Pro Glu Thr Thr Ala Ala Pro Pro Thr 
225                 230                 235                 240 


Pro Ser Ala Thr Thr Pro Ala Pro Leu Ser Ser Ser Ala Pro Pro Glu 
                245                 250                 255     


Thr Thr Ala Val Pro Pro Thr Pro Ser Ala Thr Thr Leu Asp Pro Ser 
            260                 265                 270         


Ser Ala Ser Ala Pro Pro Glu Thr Thr Ala Ala Pro Pro Thr Pro Ser 
        275                 280                 285             


Ala Thr Thr Pro Ala Pro Pro Ser Ser Pro Ala Pro Gln Glu Thr Thr 
    290                 295                 300                 


Ala Ala Pro Ile Thr Thr Pro Asn Ser Ser Pro Thr Thr Leu Ala Pro 
305                 310                 315                 320 


Asp Thr Ser Glu Thr Ser Ala Ala Pro Thr His Gln Thr Thr Thr Ser 
                325                 330                 335     


Val Thr Thr Gln Thr Thr Thr Thr Lys Gln Pro Thr Ser Ala Pro Gly 
            340                 345                 350         


Gln Asn Lys Ile Ser Arg Phe Leu Leu Tyr Met Lys Asn Leu Leu Asn 
        355                 360                 365             


Arg Ile Ile Asp Asp Met Val Glu Gln 
    370                 375         


<210>  9115
<211>  377
<212>  PRT
<213>  Homo Sapiens

<400>  9115

Met Lys Thr Leu Pro Leu Phe Val Cys Ile Cys Ala Leu Ser Ala Cys 
1               5                   10                  15      


Phe Ser Phe Ser Glu Gly Arg Glu Arg Asp His Glu Leu Arg His Arg 
            20                  25                  30          


Arg His His His Gln Ser Pro Lys Ser His Phe Glu Leu Pro His Tyr 
        35                  40                  45              


Pro Gly Leu Leu Ala His Gln Lys Pro Phe Ile Arg Lys Ser Tyr Lys 
    50                  55                  60                  


Cys Leu His Lys Arg Cys Arg Pro Lys Leu Pro Pro Ser Pro Asn Asn 
65                  70                  75                  80  


Pro Pro Lys Phe Pro Asn Pro His Gln Pro Pro Lys His Pro Asp Lys 
                85                  90                  95      


Asn Ser Ser Val Val Asn Pro Thr Leu Val Ala Thr Thr Gln Ile Pro 
            100                 105                 110         


Ser Val Thr Phe Pro Ser Ala Ser Thr Lys Ile Thr Thr Leu Pro Asn 
        115                 120                 125             


Val Thr Phe Leu Pro Gln Asn Ala Thr Thr Ile Ser Ser Arg Glu Asn 
    130                 135                 140                 


Val Asn Thr Ser Ser Ser Val Ala Thr Leu Ala Pro Val Asn Ser Pro 
145                 150                 155                 160 


Ala Pro Gln Asp Thr Thr Ala Ala Pro Pro Thr Pro Ser Ala Thr Thr 
                165                 170                 175     


Pro Ala Pro Pro Ser Ser Ser Ala Pro Pro Glu Thr Thr Ala Ala Pro 
            180                 185                 190         


Pro Thr Pro Ser Ala Thr Thr Gln Ala Pro Pro Ser Ser Ser Ala Pro 
        195                 200                 205             


Pro Glu Thr Thr Ala Ala Pro Pro Thr Pro Pro Ala Thr Thr Pro Ala 
    210                 215                 220                 


Pro Pro Ser Ser Ser Ala Pro Pro Glu Thr Thr Ala Ala Pro Pro Thr 
225                 230                 235                 240 


Pro Ser Ala Thr Thr Pro Ala Pro Leu Ser Ser Ser Ala Pro Pro Glu 
                245                 250                 255     


Thr Thr Ala Val Pro Pro Thr Pro Ser Ala Thr Thr Leu Asp Pro Ser 
            260                 265                 270         


Ser Ala Ser Ala Pro Pro Glu Thr Thr Ala Ala Pro Pro Thr Pro Ser 
        275                 280                 285             


Ala Thr Thr Pro Ala Pro Pro Ser Ser Pro Ala Pro Gln Glu Thr Thr 
    290                 295                 300                 


Ala Ala Pro Ile Thr Thr Pro Asn Ser Ser Pro Thr Thr Leu Ala Pro 
305                 310                 315                 320 


Asp Thr Ser Glu Thr Ser Ala Ala Pro Thr His Gln Thr Thr Thr Ser 
                325                 330                 335     


Val Thr Thr Gln Thr Thr Thr Thr Lys Gln Pro Thr Ser Ala Pro Gly 
            340                 345                 350         


Gln Asn Lys Ile Ser Arg Phe Leu Leu Tyr Met Lys Asn Leu Leu Asn 
        355                 360                 365             


Arg Ile Ile Asp Asp Met Val Glu Gln 
    370                 375         


<210>  9116
<211>  85
<212>  PRT
<213>  Homo Sapiens

<400>  9116

Met Gly Gly Asp His Gly Tyr Gln Leu Ala Val Thr Lys Ala Glu Asn 
1               5                   10                  15      


Pro Thr Thr Ala Ala Pro Ala Asp Thr Tyr Pro Ala Thr Gly Pro Ala 
            20                  25                  30          


Asp Asp Glu Ala Pro Asp Ala Glu Thr Thr Ala Ala Ala Thr Thr Ala 
        35                  40                  45              


Thr Thr Ala Ala Pro Thr Thr Ala Thr Thr Ala Ala Ser Thr Thr Ala 
    50                  55                  60                  


Arg Lys Asp Ile Pro Val Leu Pro Lys Trp Val Gly Asp Leu Pro Asn 
65                  70                  75                  80  


Gly Arg Val Cys Pro 
                85  


<210>  9117
<211>  90
<212>  PRT
<213>  Homo Sapiens

<400>  9117

Met Lys Phe Leu Ala Val Leu Val Leu Leu Gly Val Ser Ile Phe Leu 
1               5                   10                  15      


Val Ser Ala Gln Asn Pro Thr Thr Ala Ala Pro Ala Asp Thr Tyr Pro 
            20                  25                  30          


Ala Thr Gly Pro Ala Asp Asp Glu Ala Pro Asp Ala Glu Thr Thr Ala 
        35                  40                  45              


Ala Ala Thr Thr Ala Thr Thr Ala Ala Pro Thr Thr Ala Thr Thr Ala 
    50                  55                  60                  


Ala Ser Thr Thr Ala Arg Lys Asp Ile Pro Val Leu Pro Lys Trp Val 
65                  70                  75                  80  


Gly Asp Leu Pro Asn Gly Arg Val Cys Pro 
                85                  90  


<210>  9118
<211>  80
<212>  PRT
<213>  Homo Sapiens

<400>  9118

Met Lys Phe Leu Ala Val Leu Val Leu Leu Gly Val Ser Ile Phe Leu 
1               5                   10                  15      


Val Ser Ala Gln Asn Pro Thr Thr Ala Ala Pro Ala Asp Thr Tyr Pro 
            20                  25                  30          


Ala Thr Gly Pro Ala Asp Asp Glu Ala Pro Asp Ala Glu Thr Thr Pro 
        35                  40                  45              


Thr Thr Ala Thr Thr Ala Ala Ser Thr Thr Ala Arg Lys Asp Ile Pro 
    50                  55                  60                  


Val Leu Pro Lys Trp Val Gly Asp Leu Pro Asn Gly Arg Val Cys Pro 
65                  70                  75                  80  


<210>  9119
<211>  2828
<212>  PRT
<213>  Homo Sapiens

<400>  9119

Met Pro Lys Arg Ala His Trp Gly Ala Leu Ser Val Val Leu Ile Leu 
1               5                   10                  15      


Leu Trp Gly His Pro Arg Val Ala Leu Ala Cys Pro His Pro Cys Ala 
            20                  25                  30          


Cys Tyr Val Pro Ser Glu Val His Cys Thr Phe Arg Ser Leu Ala Ser 
        35                  40                  45              


Val Pro Ala Gly Ile Ala Lys His Val Glu Arg Ile Asn Leu Gly Phe 
    50                  55                  60                  


Asn Ser Ile Gln Ala Leu Ser Glu Thr Ser Phe Ala Gly Leu Thr Lys 
65                  70                  75                  80  


Leu Glu Leu Leu Met Ile His Gly Asn Glu Ile Pro Ser Ile Pro Asp 
                85                  90                  95      


Gly Ala Leu Arg Asp Leu Ser Ser Leu Gln Val Phe Lys Phe Ser Tyr 
            100                 105                 110         


Asn Lys Leu Arg Val Ile Thr Gly Gln Thr Leu Gln Gly Leu Ser Asn 
        115                 120                 125             


Leu Met Arg Leu His Ile Asp His Asn Lys Ile Glu Phe Ile His Pro 
    130                 135                 140                 


Gln Ala Phe Asn Gly Leu Thr Ser Leu Arg Leu Leu His Leu Glu Gly 
145                 150                 155                 160 


Asn Leu Leu His Gln Leu His Pro Ser Thr Phe Ser Thr Phe Thr Phe 
                165                 170                 175     


Leu Asp Tyr Phe Arg Leu Ser Thr Ile Arg His Leu Tyr Leu Ala Glu 
            180                 185                 190         


Asn Met Val Arg Thr Leu Pro Ala Ser Met Leu Arg Asn Met Pro Leu 
        195                 200                 205             


Leu Glu Asn Leu Tyr Leu Gln Gly Asn Pro Trp Thr Cys Asp Cys Glu 
    210                 215                 220                 


Met Arg Trp Phe Leu Glu Trp Asp Ala Lys Ser Arg Gly Ile Leu Lys 
225                 230                 235                 240 


Cys Lys Lys Asp Lys Ala Tyr Glu Gly Gly Gln Leu Cys Ala Met Cys 
                245                 250                 255     


Phe Ser Pro Lys Lys Leu Tyr Lys His Glu Ile His Lys Leu Lys Asp 
            260                 265                 270         


Met Thr Cys Leu Lys Pro Ser Ile Glu Ser Pro Leu Arg Gln Asn Arg 
        275                 280                 285             


Ser Arg Ser Ile Glu Glu Glu Gln Glu Gln Glu Glu Asp Gly Gly Ser 
    290                 295                 300                 


Gln Leu Ile Leu Glu Lys Phe Gln Leu Pro Gln Trp Ser Ile Ser Leu 
305                 310                 315                 320 


Asn Met Thr Asp Glu His Gly Asn Met Val Asn Leu Val Cys Asp Ile 
                325                 330                 335     


Lys Lys Pro Met Asp Val Tyr Lys Ile His Leu Asn Gln Thr Asp Pro 
            340                 345                 350         


Pro Asp Ile Asp Ile Asn Ala Thr Val Ala Leu Asp Phe Glu Cys Pro 
        355                 360                 365             


Met Thr Arg Glu Asn Tyr Glu Lys Leu Trp Lys Leu Ile Ala Tyr Tyr 
    370                 375                 380                 


Ser Glu Val Pro Val Lys Leu His Arg Glu Leu Met Leu Ser Lys Asp 
385                 390                 395                 400 


Pro Arg Val Ser Tyr Gln Tyr Arg Gln Asp Ala Asp Glu Glu Ala Leu 
                405                 410                 415     


Tyr Tyr Thr Gly Val Arg Ala Gln Ile Leu Ala Glu Pro Glu Trp Val 
            420                 425                 430         


Met Gln Pro Ser Ile Asp Ile Gln Leu Asn Arg Arg Gln Ser Thr Ala 
        435                 440                 445             


Lys Lys Val Leu Leu Ser Tyr Tyr Thr Gln Tyr Ser Gln Thr Ile Ser 
    450                 455                 460                 


Thr Lys Asp Thr Arg Gln Ala Arg Gly Arg Ser Trp Val Met Ile Glu 
465                 470                 475                 480 


Pro Ser Gly Ala Val Gln Arg Asp Gln Thr Val Leu Glu Gly Gly Pro 
                485                 490                 495     


Cys Gln Leu Ser Cys Asn Val Lys Ala Ser Glu Ser Pro Ser Ile Phe 
            500                 505                 510         


Trp Val Leu Pro Asp Gly Ser Ile Leu Lys Ala Pro Met Asp Asp Pro 
        515                 520                 525             


Asp Ser Lys Phe Ser Ile Leu Ser Ser Gly Trp Leu Arg Ile Lys Ser 
    530                 535                 540                 


Met Glu Pro Ser Asp Ser Gly Leu Tyr Gln Cys Ile Ala Gln Val Arg 
545                 550                 555                 560 


Asp Glu Met Asp Arg Met Val Tyr Arg Val Leu Val Gln Ser Pro Ser 
                565                 570                 575     


Thr Gln Pro Ala Glu Lys Asp Thr Val Thr Ile Gly Lys Asn Pro Gly 
            580                 585                 590         


Glu Ser Val Thr Leu Pro Cys Asn Ala Leu Ala Ile Pro Glu Ala His 
        595                 600                 605             


Leu Ser Trp Ile Leu Pro Asn Arg Arg Ile Ile Asn Asp Leu Ala Asn 
    610                 615                 620                 


Thr Ser His Val Tyr Met Leu Pro Asn Gly Thr Leu Ser Ile Pro Lys 
625                 630                 635                 640 


Val Gln Val Ser Asp Ser Gly Tyr Tyr Arg Cys Val Ala Val Asn Gln 
                645                 650                 655     


Gln Gly Ala Asp His Phe Thr Val Gly Ile Thr Val Thr Lys Lys Gly 
            660                 665                 670         


Ser Gly Leu Pro Ser Lys Arg Gly Arg Arg Pro Gly Ala Lys Ala Leu 
        675                 680                 685             


Ser Arg Val Arg Glu Asp Ile Val Glu Asp Glu Gly Gly Ser Gly Met 
    690                 695                 700                 


Gly Asp Glu Glu Asn Thr Ser Arg Arg Leu Leu His Pro Lys Asp Gln 
705                 710                 715                 720 


Glu Val Phe Leu Lys Thr Lys Asp Asp Ala Ile Asn Gly Asp Lys Lys 
                725                 730                 735     


Ala Lys Lys Gly Arg Arg Lys Leu Lys Leu Trp Lys His Ser Glu Lys 
            740                 745                 750         


Glu Pro Glu Thr Asn Val Ala Glu Gly Arg Arg Val Phe Glu Ser Arg 
        755                 760                 765             


Arg Arg Ile Asn Met Ala Asn Lys Gln Ile Asn Pro Glu Arg Trp Ala 
    770                 775                 780                 


Asp Ile Leu Ala Lys Val Arg Gly Lys Asn Leu Pro Lys Gly Thr Glu 
785                 790                 795                 800 


Val Pro Pro Leu Ile Lys Thr Thr Ser Pro Pro Ser Leu Ser Leu Glu 
                805                 810                 815     


Val Thr Pro Pro Phe Pro Ala Ile Ser Pro Pro Ser Ala Ser Pro Val 
            820                 825                 830         


Gln Thr Val Thr Ser Ala Glu Glu Ser Ser Ala Asp Val Pro Leu Leu 
        835                 840                 845             


Gly Glu Glu Glu His Val Leu Gly Thr Ile Ser Ser Ala Ser Met Gly 
    850                 855                 860                 


Leu Glu His Asn His Asn Gly Val Ile Leu Val Glu Pro Glu Val Thr 
865                 870                 875                 880 


Ser Thr Pro Leu Glu Glu Val Val Asp Asp Leu Ser Glu Lys Thr Glu 
                885                 890                 895     


Glu Ile Thr Ser Thr Glu Gly Asp Leu Lys Gly Thr Ala Ala Pro Thr 
            900                 905                 910         


Leu Ile Ser Glu Pro Tyr Glu Pro Ser Pro Thr Leu His Thr Leu Asp 
        915                 920                 925             


Thr Val Tyr Glu Lys Pro Thr His Glu Glu Thr Ala Thr Glu Gly Trp 
    930                 935                 940                 


Ser Ala Ala Asp Val Gly Ser Ser Pro Glu Pro Thr Ser Ser Glu Tyr 
945                 950                 955                 960 


Glu Pro Pro Leu Asp Ala Val Ser Leu Ala Glu Ser Glu Pro Met Gln 
                965                 970                 975     


Tyr Phe Asp Pro Asp Leu Glu Thr Lys Ser Gln Pro Asp Glu Asp Lys 
            980                 985                 990         


Met Lys Glu Asp Thr Phe Ala His  Leu Thr Pro Thr Pro  Thr Ile Trp 
        995                 1000                 1005             


Val Asn  Asp Ser Ser Thr Ser  Gln Leu Phe Glu Asp  Ser Thr Ile 
    1010                 1015                 1020             


Gly Glu  Pro Gly Val Pro Gly  Gln Ser His Leu Gln  Gly Leu Thr 
    1025                 1030                 1035             


Asp Asn  Ile His Leu Val Lys  Ser Ser Leu Ser Thr  Gln Asp Thr 
    1040                 1045                 1050             


Leu Leu  Ile Lys Lys Gly Met  Lys Glu Met Ser Gln  Thr Leu Gln 
    1055                 1060                 1065             


Gly Gly  Asn Met Leu Glu Gly  Asp Pro Thr His Ser  Arg Ser Ser 
    1070                 1075                 1080             


Glu Ser  Glu Gly Gln Glu Ser  Lys Ser Ile Thr Leu  Pro Asp Ser 
    1085                 1090                 1095             


Thr Leu  Gly Ile Met Ser Ser  Met Ser Pro Val Lys  Lys Pro Ala 
    1100                 1105                 1110             


Glu Thr  Thr Val Gly Thr Leu  Leu Asp Lys Asp Thr  Thr Thr Ala 
    1115                 1120                 1125             


Thr Thr  Thr Pro Arg Gln Lys  Val Ala Pro Ser Ser  Thr Met Ser 
    1130                 1135                 1140             


Thr His  Pro Ser Arg Arg Arg  Pro Asn Gly Arg Arg  Arg Leu Arg 
    1145                 1150                 1155             


Pro Asn  Lys Phe Arg His Arg  His Lys Gln Thr Pro  Pro Thr Thr 
    1160                 1165                 1170             


Phe Ala  Pro Ser Glu Thr Phe  Ser Thr Gln Pro Thr  Gln Ala Pro 
    1175                 1180                 1185             


Asp Ile  Lys Ile Ser Ser Gln  Val Glu Ser Ser Leu  Val Pro Thr 
    1190                 1195                 1200             


Ala Trp  Val Asp Asn Thr Val  Asn Thr Pro Lys Gln  Leu Glu Met 
    1205                 1210                 1215             


Glu Lys  Asn Ala Glu Pro Thr  Ser Lys Gly Thr Pro  Arg Arg Lys 
    1220                 1225                 1230             


His Gly  Lys Arg Pro Asn Lys  His Arg Tyr Thr Pro  Ser Thr Val 
    1235                 1240                 1245             


Ser Ser  Arg Ala Ser Gly Ser  Lys Pro Ser Pro Ser  Pro Glu Asn 
    1250                 1255                 1260             


Lys His  Arg Asn Ile Val Thr  Pro Ser Ser Glu Thr  Ile Leu Leu 
    1265                 1270                 1275             


Pro Arg  Thr Val Ser Leu Lys  Thr Glu Gly Pro Tyr  Asp Ser Leu 
    1280                 1285                 1290             


Asp Tyr  Met Thr Thr Thr Arg  Lys Ile Tyr Ser Ser  Tyr Pro Lys 
    1295                 1300                 1305             


Val Gln  Glu Thr Leu Pro Val  Thr Tyr Lys Pro Thr  Ser Asp Gly 
    1310                 1315                 1320             


Lys Glu  Ile Lys Asp Asp Val  Ala Thr Asn Val Asp  Lys His Lys 
    1325                 1330                 1335             


Ser Asp  Ile Leu Val Thr Gly  Glu Ser Ile Thr Asn  Ala Ile Pro 
    1340                 1345                 1350             


Thr Ser  Arg Ser Leu Val Ser  Thr Met Gly Glu Phe  Lys Glu Glu 
    1355                 1360                 1365             


Ser Ser  Pro Val Gly Phe Pro  Gly Thr Pro Thr Trp  Asn Pro Ser 
    1370                 1375                 1380             


Arg Thr  Ala Gln Pro Gly Arg  Leu Gln Thr Gly Ile  Pro Val Thr 
    1385                 1390                 1395             


Thr Ser  Gly Glu Asn Leu Thr  Asp Pro Pro Leu Leu  Lys Glu Leu 
    1400                 1405                 1410             


Glu Asp  Val Asp Phe Thr Ser  Glu Phe Leu Ser Ser  Leu Thr Val 
    1415                 1420                 1425             


Ser Thr  Pro Phe His Gln Glu  Glu Ala Gly Ser Ser  Thr Thr Leu 
    1430                 1435                 1440             


Ser Ser  Ile Lys Val Glu Val  Ala Ser Ser Gln Ala  Glu Thr Thr 
    1445                 1450                 1455             


Thr Leu  Asp Gln Asp His Leu  Glu Thr Thr Val Ala  Ile Leu Leu 
    1460                 1465                 1470             


Ser Glu  Thr Arg Pro Gln Asn  His Thr Pro Thr Ala  Ala Arg Met 
    1475                 1480                 1485             


Lys Glu  Pro Ala Ser Ser Ser  Pro Ser Thr Ile Leu  Met Ser Leu 
    1490                 1495                 1500             


Gly Gln  Thr Thr Thr Thr Lys  Pro Ala Leu Pro Ser  Pro Arg Ile 
    1505                 1510                 1515             


Ser Gln  Ala Ser Arg Asp Ser  Lys Glu Asn Val Phe  Leu Asn Tyr 
    1520                 1525                 1530             


Val Gly  Asn Pro Glu Thr Glu  Ala Thr Pro Val Asn  Asn Glu Gly 
    1535                 1540                 1545             


Thr Gln  His Met Ser Gly Pro  Asn Glu Leu Ser Thr  Pro Ser Ser 
    1550                 1555                 1560             


Asp Gln  Asp Ala Phe Asn Leu  Ser Thr Lys Leu Glu  Leu Glu Lys 
    1565                 1570                 1575             


Gln Val  Phe Gly Ser Arg Ser  Leu Pro Arg Gly Pro  Asp Ser Gln 
    1580                 1585                 1590             


Arg Gln  Asp Gly Arg Val His  Ala Ser His Gln Leu  Thr Arg Val 
    1595                 1600                 1605             


Pro Ala  Lys Pro Ile Leu Pro  Thr Ala Thr Val Arg  Leu Pro Glu 
    1610                 1615                 1620             


Met Ser  Thr Gln Ser Ala Ser  Arg Tyr Phe Val Thr  Ser Gln Ser 
    1625                 1630                 1635             


Pro Arg  His Trp Thr Asn Lys  Pro Glu Ile Thr Thr  Tyr Pro Ser 
    1640                 1645                 1650             


Gly Ala  Leu Pro Glu Asn Lys  Gln Phe Thr Thr Pro  Arg Leu Ser 
    1655                 1660                 1665             


Ser Thr  Thr Ile Pro Leu Pro  Leu His Met Ser Lys  Pro Ser Ile 
    1670                 1675                 1680             


Pro Ser  Lys Phe Thr Asp Arg  Arg Thr Asp Gln Phe  Asn Gly Tyr 
    1685                 1690                 1695             


Ser Lys  Val Phe Gly Asn Asn  Asn Ile Pro Glu Ala  Arg Asn Pro 
    1700                 1705                 1710             


Val Gly  Lys Pro Pro Ser Pro  Arg Ile Pro His Tyr  Ser Asn Gly 
    1715                 1720                 1725             


Arg Leu  Pro Phe Phe Thr Asn  Lys Thr Leu Ser Phe  Pro Gln Leu 
    1730                 1735                 1740             


Gly Val  Thr Arg Arg Pro Gln  Ile Pro Thr Ser Pro  Ala Pro Val 
    1745                 1750                 1755             


Met Arg  Glu Arg Lys Val Ile  Pro Gly Ser Tyr Asn  Arg Ile His 
    1760                 1765                 1770             


Ser His  Ser Thr Phe His Leu  Asp Phe Gly Pro Pro  Ala Pro Pro 
    1775                 1780                 1785             


Leu Leu  His Thr Pro Gln Thr  Thr Gly Ser Pro Ser  Thr Asn Leu 
    1790                 1795                 1800             


Gln Asn  Ile Pro Met Val Ser  Ser Thr Gln Ser Ser  Ile Ser Phe 
    1805                 1810                 1815             


Ile Thr  Ser Ser Val Gln Ser  Ser Gly Ser Phe His  Gln Ser Ser 
    1820                 1825                 1830             


Ser Lys  Phe Phe Ala Gly Gly  Pro Pro Ala Ser Lys  Phe Trp Ser 
    1835                 1840                 1845             


Leu Gly  Glu Lys Pro Gln Ile  Leu Thr Lys Ser Pro  Gln Thr Val 
    1850                 1855                 1860             


Ser Val  Thr Ala Glu Thr Asp  Thr Val Phe Pro Cys  Glu Ala Thr 
    1865                 1870                 1875             


Gly Lys  Pro Lys Pro Phe Val  Thr Trp Thr Lys Val  Ser Thr Gly 
    1880                 1885                 1890             


Ala Leu  Met Thr Pro Asn Thr  Arg Ile Gln Arg Phe  Glu Val Leu 
    1895                 1900                 1905             


Lys Asn  Gly Thr Leu Val Ile  Arg Lys Val Gln Val  Gln Asp Arg 
    1910                 1915                 1920             


Gly Gln  Tyr Met Cys Thr Ala  Ser Asn Leu His Gly  Leu Asp Arg 
    1925                 1930                 1935             


Met Val  Val Leu Leu Ser Val  Thr Val Gln Gln Pro  Gln Ile Leu 
    1940                 1945                 1950             


Ala Ser  His Tyr Gln Asp Val  Thr Val Tyr Leu Gly  Asp Thr Ile 
    1955                 1960                 1965             


Ala Met  Glu Cys Leu Ala Lys  Gly Thr Pro Ala Pro  Gln Ile Ser 
    1970                 1975                 1980             


Trp Ile  Phe Pro Asp Arg Arg  Val Trp Gln Thr Val  Ser Pro Val 
    1985                 1990                 1995             


Glu Gly  Arg Ile Thr Leu His  Glu Asn Arg Thr Leu  Ser Ile Lys 
    2000                 2005                 2010             


Glu Ala  Ser Phe Ser Asp Arg  Gly Val Tyr Lys Cys  Val Ala Ser 
    2015                 2020                 2025             


Asn Ala  Ala Gly Ala Asp Ser  Leu Ala Ile Arg Leu  His Val Ala 
    2030                 2035                 2040             


Ala Leu  Pro Pro Val Ile His  Gln Glu Lys Leu Glu  Asn Ile Ser 
    2045                 2050                 2055             


Leu Pro  Pro Gly Leu Ser Ile  His Ile His Cys Thr  Ala Lys Ala 
    2060                 2065                 2070             


Ala Pro  Leu Pro Ser Val Arg  Trp Val Leu Gly Asp  Gly Thr Gln 
    2075                 2080                 2085             


Ile Arg  Pro Ser Gln Phe Leu  His Gly Asn Leu Phe  Val Phe Pro 
    2090                 2095                 2100             


Asn Gly  Thr Leu Tyr Ile Arg  Asn Leu Ala Pro Lys  Asp Ser Gly 
    2105                 2110                 2115             


Arg Tyr  Glu Cys Val Ala Ala  Asn Leu Val Gly Ser  Ala Arg Arg 
    2120                 2125                 2130             


Thr Val  Gln Leu Asn Val Gln  Arg Ala Ala Ala Asn  Ala Arg Ile 
    2135                 2140                 2145             


Thr Gly  Thr Ser Pro Arg Arg  Thr Asp Val Arg Tyr  Gly Gly Thr 
    2150                 2155                 2160             


Leu Lys  Leu Asp Cys Ser Ala  Ser Gly Asp Pro Trp  Pro Arg Ile 
    2165                 2170                 2175             


Leu Trp  Arg Leu Pro Ser Lys  Arg Met Ile Asp Ala  Leu Phe Ser 
    2180                 2185                 2190             


Phe Asp  Ser Arg Ile Lys Val  Phe Ala Asn Gly Thr  Leu Val Val 
    2195                 2200                 2205             


Lys Ser  Val Thr Asp Lys Asp  Ala Gly Asp Tyr Leu  Cys Val Ala 
    2210                 2215                 2220             


Arg Asn  Lys Val Gly Asp Asp  Tyr Val Val Leu Lys  Val Asp Val 
    2225                 2230                 2235             


Val Met  Lys Pro Ala Lys Ile  Glu His Lys Glu Glu  Asn Asp His 
    2240                 2245                 2250             


Lys Val  Phe Tyr Gly Gly Asp  Leu Lys Val Asp Cys  Val Ala Thr 
    2255                 2260                 2265             


Gly Leu  Pro Asn Pro Glu Ile  Ser Trp Ser Leu Pro  Asp Gly Ser 
    2270                 2275                 2280             


Leu Val  Asn Ser Phe Met Gln  Ser Asp Asp Ser Gly  Gly Arg Thr 
    2285                 2290                 2295             


Lys Arg  Tyr Val Val Phe Asn  Asn Gly Thr Leu Tyr  Phe Asn Glu 
    2300                 2305                 2310             


Val Gly  Met Arg Glu Glu Gly  Asp Tyr Thr Cys Phe  Ala Glu Asn 
    2315                 2320                 2325             


Gln Val  Gly Lys Asp Glu Met  Arg Val Arg Val Lys  Val Val Thr 
    2330                 2335                 2340             


Ala Pro  Ala Thr Ile Arg Asn  Lys Thr Tyr Leu Ala  Val Gln Val 
    2345                 2350                 2355             


Pro Tyr  Gly Asp Val Val Thr  Val Ala Cys Glu Ala  Lys Gly Glu 
    2360                 2365                 2370             


Pro Met  Pro Lys Val Thr Trp  Leu Ser Pro Thr Asn  Lys Val Ile 
    2375                 2380                 2385             


Pro Thr  Ser Ser Glu Lys Tyr  Gln Ile Tyr Gln Asp  Gly Thr Leu 
    2390                 2395                 2400             


Leu Ile  Gln Lys Ala Gln Arg  Ser Asp Ser Gly Asn  Tyr Thr Cys 
    2405                 2410                 2415             


Leu Val  Arg Asn Ser Ala Gly  Glu Asp Arg Lys Thr  Val Trp Ile 
    2420                 2425                 2430             


His Val  Asn Val Gln Pro Pro  Lys Ile Asn Gly Asn  Pro Asn Pro 
    2435                 2440                 2445             


Ile Thr  Thr Val Arg Glu Ile  Ala Ala Gly Gly Ser  Arg Lys Leu 
    2450                 2455                 2460             


Ile Asp  Cys Lys Ala Glu Gly  Ile Pro Thr Pro Arg  Val Leu Trp 
    2465                 2470                 2475             


Ala Phe  Pro Glu Gly Val Val  Leu Pro Ala Pro Tyr  Tyr Gly Asn 
    2480                 2485                 2490             


Arg Ile  Thr Val His Gly Asn  Gly Ser Leu Asp Ile  Arg Ser Leu 
    2495                 2500                 2505             


Arg Lys  Ser Asp Ser Val Gln  Leu Val Cys Met Ala  Arg Asn Glu 
    2510                 2515                 2520             


Gly Gly  Glu Ala Arg Leu Ile  Leu Gln Leu Thr Val  Leu Glu Pro 
    2525                 2530                 2535             


Met Glu  Lys Pro Ile Phe His  Asp Pro Ile Ser Glu  Lys Ile Thr 
    2540                 2545                 2550             


Ala Met  Ala Gly His Thr Ile  Ser Leu Asn Cys Ser  Ala Ala Gly 
    2555                 2560                 2565             


Thr Pro  Thr Pro Ser Leu Val  Trp Val Leu Pro Asn  Gly Thr Asp 
    2570                 2575                 2580             


Leu Gln  Ser Gly Gln Gln Leu  Gln Arg Phe Tyr His  Lys Ala Asp 
    2585                 2590                 2595             


Gly Met  Leu His Ile Ser Gly  Leu Ser Ser Val Asp  Ala Gly Ala 
    2600                 2605                 2610             


Tyr Arg  Cys Val Ala Arg Asn  Ala Ala Gly His Thr  Glu Arg Leu 
    2615                 2620                 2625             


Val Ser  Leu Lys Val Gly Leu  Lys Pro Glu Ala Asn  Lys Gln Tyr 
    2630                 2635                 2640             


His Asn  Leu Val Ser Ile Ile  Asn Gly Glu Thr Leu  Lys Leu Pro 
    2645                 2650                 2655             


Cys Thr  Pro Pro Gly Ala Gly  Gln Gly Arg Phe Ser  Trp Thr Leu 
    2660                 2665                 2670             


Pro Asn  Gly Met His Leu Glu  Gly Pro Gln Thr Leu  Gly Arg Val 
    2675                 2680                 2685             


Ser Leu  Leu Asp Asn Gly Thr  Leu Thr Val Arg Glu  Ala Ser Val 
    2690                 2695                 2700             


Phe Asp  Arg Gly Thr Tyr Val  Cys Arg Met Glu Thr  Glu Tyr Gly 
    2705                 2710                 2715             


Pro Ser  Val Thr Ser Ile Pro  Val Ile Val Ile Ala  Tyr Pro Pro 
    2720                 2725                 2730             


Arg Ile  Thr Ser Glu Pro Thr  Pro Val Ile Tyr Thr  Arg Pro Gly 
    2735                 2740                 2745             


Asn Thr  Val Lys Leu Asn Cys  Met Ala Met Gly Ile  Pro Lys Ala 
    2750                 2755                 2760             


Asp Ile  Thr Trp Glu Leu Pro  Asp Lys Ser His Leu  Lys Ala Gly 
    2765                 2770                 2775             


Val Gln  Ala Arg Leu Tyr Gly  Asn Arg Phe Leu His  Pro Gln Gly 
    2780                 2785                 2790             


Ser Leu  Thr Ile Gln His Ala  Thr Gln Arg Asp Ala  Gly Phe Tyr 
    2795                 2800                 2805             


Lys Cys  Met Ala Lys Asn Ile  Leu Gly Ser Asp Ser  Lys Thr Thr 
    2810                 2815                 2820             


Tyr Ile  His Val Phe 
    2825             


<210>  9120
<211>  213
<212>  PRT
<213>  Homo Sapiens

<400>  9120

Met Asp Thr Glu Arg Val Gly Asp Gly Lys Gln His Arg Arg Lys Gln 
1               5                   10                  15      


Ser Gln Arg Leu Arg Trp Pro Cys Cys Leu Ala Leu Val Pro Asp Arg 
            20                  25                  30          


His Pro Ser Gln Leu Ser Ser Cys Thr Leu Cys Leu Leu Ala Ala Ala 
        35                  40                  45              


Ser Gln Trp Glu Ser Trp Ala His Phe Ser Lys Trp His Thr Glu Ala 
    50                  55                  60                  


Ser Thr Gly Thr His Leu Gly Lys Ala Lys Ala Glu Gly Leu Gly Cys 
65                  70                  75                  80  


Thr Val Lys Asn Thr Pro Gln Leu Ser Ile Cys Glu Pro Ser His Phe 
                85                  90                  95      


Gly Pro Ser Phe Val His Ser Pro His Leu Leu Val Asp His Asp His 
            100                 105                 110         


Arg Ala Gly Ala Ala Thr Gly Arg Gly Gln Ala Gly Pro Ser Arg Ala 
        115                 120                 125             


Ser Ser Val Ser Pro Thr Phe Cys Pro Pro Thr Thr Ser His His Pro 
    130                 135                 140                 


Val Cys Ala Lys Gly Thr Asp Pro Val Leu Val Leu Gln Glu Glu Glu 
145                 150                 155                 160 


Gln Asp Leu Asp Gly Glu Lys Gly Pro Ser Ser Glu Gly Pro Glu Glu 
                165                 170                 175     


Glu Asp Gly Glu Gly Phe Ser Phe Lys Tyr Ser Pro Gly Lys Leu Arg 
            180                 185                 190         


Gly Asn Gln Tyr Lys Lys Met Met Thr Lys Glu Glu Leu Glu Glu Glu 
        195                 200                 205             


Gln Arg Thr Glu Glu 
    210             


<210>  9121
<211>  177
<212>  PRT
<213>  Homo Sapiens

<400>  9121

Met Glu Ala Pro Ala Glu Leu Leu Ala Ala Leu Pro Ala Leu Ala Thr 
1               5                   10                  15      


Ala Leu Ala Leu Leu Leu Ala Trp Leu Leu Val Arg Arg Gly Ala Ala 
            20                  25                  30          


Ala Ser Pro Glu Pro Ala Arg Ala Pro Pro Glu Pro Ala Pro Pro Ala 
        35                  40                  45              


Glu Ala Thr Gly Ala Pro Ala Pro Ser Arg Pro Cys Ala Pro Glu Pro 
    50                  55                  60                  


Ala Ala Ser Pro Ala Gly Pro Glu Glu Pro Gly Glu Pro Ala Gly Leu 
65                  70                  75                  80  


Gly Glu Leu Gly Glu Pro Ala Gly Pro Gly Glu Pro Glu Gly Pro Gly 
                85                  90                  95      


Asp Pro Ala Ala Ala Pro Ala Glu Ala Glu Glu Gln Ala Val Glu Ala 
            100                 105                 110         


Arg Gln Glu Glu Glu Gln Asp Leu Asp Gly Glu Lys Gly Pro Ser Ser 
        115                 120                 125             


Glu Gly Pro Glu Glu Glu Asp Gly Glu Gly Phe Ser Phe Lys Tyr Ser 
    130                 135                 140                 


Pro Gly Lys Leu Arg Gly Asn Gln Tyr Lys Lys Met Met Thr Lys Glu 
145                 150                 155                 160 


Glu Leu Glu Glu Glu Gln Arg Ile Glu Leu Thr Ser Asp Leu Thr Ser 
                165                 170                 175     


Leu 
    


<210>  9122
<211>  170
<212>  PRT
<213>  Homo Sapiens

<400>  9122

Met Glu Ala Pro Ala Glu Leu Leu Ala Ala Leu Pro Ala Leu Ala Thr 
1               5                   10                  15      


Ala Leu Ala Leu Leu Leu Ala Trp Leu Leu Val Arg Arg Gly Ala Ala 
            20                  25                  30          


Ala Ser Pro Glu Pro Ala Arg Ala Pro Pro Glu Pro Ala Pro Pro Ala 
        35                  40                  45              


Glu Ala Thr Gly Ala Pro Ala Pro Ser Arg Pro Cys Ala Pro Glu Pro 
    50                  55                  60                  


Ala Ala Ser Pro Ala Gly Pro Glu Glu Pro Gly Glu Pro Ala Gly Leu 
65                  70                  75                  80  


Gly Glu Leu Gly Glu Pro Ala Gly Pro Gly Glu Pro Glu Gly Pro Gly 
                85                  90                  95      


Asp Pro Ala Ala Ala Pro Ala Glu Ala Glu Glu Gln Ala Val Glu Ala 
            100                 105                 110         


Arg Gln Glu Glu Glu Gln Asp Leu Asp Gly Glu Lys Gly Pro Ser Ser 
        115                 120                 125             


Glu Gly Pro Glu Glu Glu Asp Gly Glu Gly Phe Ser Phe Lys Tyr Ser 
    130                 135                 140                 


Pro Gly Lys Leu Arg Gly Asn Gln Tyr Lys Lys Met Met Thr Lys Glu 
145                 150                 155                 160 


Glu Leu Glu Glu Glu Gln Arg Thr Glu Glu 
                165                 170 


<210>  9123
<211>  204
<212>  PRT
<213>  Homo Sapiens

<400>  9123

Met Glu Ala Pro Ala Glu Leu Leu Ala Ala Leu Pro Ala Leu Ala Thr 
1               5                   10                  15      


Ala Leu Ala Leu Leu Leu Ala Trp Leu Leu Val Arg Arg Gly Ala Ala 
            20                  25                  30          


Ala Ser Pro Glu Pro Ala Arg Ala Pro Pro Glu Pro Ala Pro Pro Ala 
        35                  40                  45              


Glu Ala Thr Gly Ala Pro Ala Pro Ser Arg Pro Cys Ala Pro Glu Pro 
    50                  55                  60                  


Ala Ala Ser Pro Ala Gly Pro Glu Glu Pro Gly Glu Pro Ala Gly Leu 
65                  70                  75                  80  


Gly Glu Leu Gly Glu Pro Ala Gly Pro Gly Glu Pro Glu Gly Pro Gly 
                85                  90                  95      


Asp Pro Ala Ala Ala Pro Ala Glu Ala Glu Glu Gln Ala Val Glu Ala 
            100                 105                 110         


Arg Gln Glu Glu Glu Gln Asp Leu Asp Gly Glu Lys Gly Pro Ser Ser 
        115                 120                 125             


Glu Gly Pro Glu Glu Glu Asp Gly Glu Gly Phe Ser Phe Lys Tyr Ser 
    130                 135                 140                 


Pro Gly Lys Leu Arg Gly Asn Gln Tyr Lys Lys Met Met Thr Lys Glu 
145                 150                 155                 160 


Glu Leu Glu Glu Glu Gln Arg Val Gln Lys Glu Gln Leu Ala Ala Ile 
                165                 170                 175     


Phe Lys Leu Met Lys Asp Asn Lys Glu Thr Phe Gly Glu Met Ser Asp 
            180                 185                 190         


Gly Asp Val Gln Glu Gln Leu Arg Leu Tyr Asp Met 
        195                 200                 


<210>  9124
<211>  22
<212>  PRT
<213>  Homo Sapiens

<400>  9124

Met Met Thr Lys Glu Glu Leu Glu Glu Glu Gln Arg Ile Glu Leu Thr 
1               5                   10                  15      


Ser Asp Leu Thr Ser Leu 
            20          


<210>  9125
<211>  15
<212>  PRT
<213>  Homo Sapiens

<400>  9125

Met Met Thr Lys Glu Glu Leu Glu Glu Glu Gln Arg Thr Glu Glu 
1               5                   10                  15  


<210>  9126
<211>  15
<212>  PRT
<213>  Homo Sapiens

<400>  9126

Met Met Thr Lys Glu Glu Leu Glu Glu Glu Gln Arg Thr Glu Glu 
1               5                   10                  15  


<210>  9127
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  9127

Met Ala Ala Pro Ser Gly Gly Trp Asn Gly Val Gly Ala Ser Leu Trp 
1               5                   10                  15      


Ala Ala Leu Leu Leu Gly Ala Val Ala Leu Arg Pro Ala Glu Ala Val 
            20                  25                  30          


Ser Glu Pro Thr Thr Val Ala Phe Asp Val Arg Pro Gly Gly Val Val 
        35                  40                  45              


His Ser Phe Ser His Asn Val Gly Pro Gly Asp Lys Tyr Thr Cys Met 
    50                  55                  60                  


Phe Thr Tyr Ala Ser Gln Gly Gly Thr Asn Glu Gln Trp Gln Met Ser 
65                  70                  75                  80  


Leu Gly Thr Ser Glu Asp His Gln His Phe Thr Cys Thr Ile Trp Arg 
                85                  90                  95      


Pro Gln Gly Lys Ser Tyr Leu Tyr Phe Thr Gln Phe Lys Ala Glu Val 
            100                 105                 110         


Arg Gly Ala Glu Ile Glu Tyr Ala Met Ala Tyr Ser Lys Ala Ala Phe 
        115                 120                 125             


Glu Arg Glu Ser Asp Val Pro Leu Lys Thr Glu Glu Phe Glu Val Thr 
    130                 135                 140                 


Lys Thr Ala Gly Thr Glu Arg Trp Gly Trp Gly Arg Gly Asp Ala Thr 
145                 150                 155                 160 


Pro Ile Gln Gly Trp Ala Ile Gly Ala Val Trp Arg Gly Gly Ser Ala 
                165                 170                 175     


Ile Gly Val Leu Glu Thr Val Asp Gln Ala Ser Thr Asn 
            180                 185                 


<210>  9128
<211>  173
<212>  PRT
<213>  Homo Sapiens

<400>  9128

Met Ala Ala Pro Ser Gly Gly Trp Asn Gly Val Gly Ala Ser Leu Trp 
1               5                   10                  15      


Ala Ala Leu Leu Leu Gly Ala Val Ala Leu Arg Pro Ala Glu Ala Val 
            20                  25                  30          


Ser Glu Pro Thr Thr Val Ala Phe Asp Val Arg Pro Gly Gly Val Val 
        35                  40                  45              


His Ser Phe Ser His Asn Val Gly Pro Gly Asp Lys Tyr Thr Cys Met 
    50                  55                  60                  


Phe Thr Tyr Ala Ser Gln Gly Gly Thr Asn Glu Gln Trp Gln Met Ser 
65                  70                  75                  80  


Leu Gly Thr Ser Glu Asp His Gln His Phe Thr Cys Thr Ile Trp Arg 
                85                  90                  95      


Pro Gln Gly Lys Ser Tyr Leu Tyr Phe Thr Gln Phe Lys Ala Glu Val 
            100                 105                 110         


Arg Gly Ala Glu Ile Glu Tyr Ala Met Ala Tyr Ser Lys Ala Ala Phe 
        115                 120                 125             


Glu Arg Glu Ser Asp Val Pro Leu Lys Thr Glu Glu Phe Glu Val Thr 
    130                 135                 140                 


Lys Thr Ala Val Ala His Arg Pro Gly Ala Phe Lys Ala Glu Leu Ser 
145                 150                 155                 160 


Lys Leu Val Ile Val Ala Lys Ala Ser Arg Thr Glu Leu 
                165                 170             


<210>  9129
<211>  84
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9129

Xaa His Gln His Phe Thr Cys Thr Ile Trp Arg Pro Gln Gly Lys Ser 
1               5                   10                  15      


Tyr Leu Tyr Phe Thr Gln Phe Lys Ala Glu Val Arg Gly Ala Glu Ile 
            20                  25                  30          


Glu Tyr Ala Met Ala Tyr Ser Lys Ala Ala Phe Glu Arg Glu Ser Asp 
        35                  40                  45              


Val Pro Leu Lys Thr Glu Glu Phe Glu Val Thr Lys Thr Ala Val Ile 
    50                  55                  60                  


Ser Ala Pro Gln Glu Lys Gly Asp Asp Gln Pro His Trp Thr Asp Gly 
65                  70                  75                  80  


Glu Thr Glu Ala 
                


<210>  9130
<211>  194
<212>  PRT
<213>  Homo Sapiens

<400>  9130

Met Ala Pro Lys Lys Asp Val Lys Lys Pro Val Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Lys 
            20                  25                  30          


Pro Lys Glu Glu Lys Ile Asp Leu Ser Ala Ile Lys Ile Glu Phe Ser 
        35                  40                  45              


Lys Glu Gln Gln Asp Glu Phe Lys Glu Ala Phe Leu Leu Phe Asp Arg 
    50                  55                  60                  


Thr Gly Asp Ser Lys Ile Thr Leu Ser Gln Val Gly Asp Val Leu Arg 
65                  70                  75                  80  


Ala Leu Gly Thr Asn Pro Thr Asn Ala Glu Val Arg Lys Val Leu Gly 
                85                  90                  95      


Asn Pro Ser Asn Glu Glu Leu Asn Ala Lys Lys Ile Glu Phe Glu Gln 
            100                 105                 110         


Phe Leu Pro Met Met Gln Ala Ile Ser Asn Asn Lys Asp Gln Ala Thr 
        115                 120                 125             


Tyr Glu Asp Phe Val Glu Gly Leu Arg Val Phe Asp Lys Glu Gly Asn 
    130                 135                 140                 


Gly Thr Val Met Gly Ala Glu Leu Arg His Val Leu Ala Thr Leu Gly 
145                 150                 155                 160 


Glu Lys Met Lys Glu Glu Glu Val Glu Ala Leu Met Ala Gly Gln Glu 
                165                 170                 175     


Asp Ser Asn Gly Cys Ile Asn Tyr Glu Ala Phe Val Lys His Ile Met 
            180                 185                 190         


Ser Ile 
        


<210>  9131
<211>  150
<212>  PRT
<213>  Homo Sapiens

<400>  9131

Met Ser Phe Ser Ala Asp Gln Ile Ala Glu Phe Lys Glu Ala Phe Leu 
1               5                   10                  15      


Leu Phe Asp Arg Thr Gly Asp Ser Lys Ile Thr Leu Ser Gln Val Gly 
            20                  25                  30          


Asp Val Leu Arg Ala Leu Gly Thr Asn Pro Thr Asn Ala Glu Val Arg 
        35                  40                  45              


Lys Val Leu Gly Asn Pro Ser Asn Glu Glu Leu Asn Ala Lys Lys Ile 
    50                  55                  60                  


Glu Phe Glu Gln Phe Leu Pro Met Met Gln Ala Ile Ser Asn Asn Lys 
65                  70                  75                  80  


Asp Gln Ala Thr Tyr Glu Asp Phe Val Glu Gly Leu Arg Val Phe Asp 
                85                  90                  95      


Lys Glu Gly Asn Gly Thr Val Met Gly Ala Glu Leu Arg His Val Leu 
            100                 105                 110         


Ala Thr Leu Gly Glu Lys Met Lys Glu Glu Glu Val Glu Ala Leu Met 
        115                 120                 125             


Ala Gly Gln Glu Asp Ser Asn Gly Cys Ile Asn Tyr Glu Ala Phe Val 
    130                 135                 140                 


Lys His Ile Met Ser Ile 
145                 150 


<210>  9132
<211>  63
<212>  PRT
<213>  Homo Sapiens

<400>  9132

Met Arg Phe Phe Cys Ala Arg Cys Cys Ser Phe Gly Pro Glu Met Pro 
1               5                   10                  15      


Ala Val Gln Leu Leu Leu Leu Ala Cys Leu Val Trp Asp Val Gly Ala 
            20                  25                  30          


Arg Thr Ala Gln Leu Arg Lys Ala Asn Asp Gln Arg Ser Phe Tyr Val 
        35                  40                  45              


Glu Phe Gly His Phe Gly Leu Pro Gly Thr Glu Val Arg Ala Asn 
    50                  55                  60              


<210>  9133
<211>  504
<212>  PRT
<213>  Homo Sapiens

<400>  9133

Met Arg Phe Phe Cys Ala Arg Cys Cys Ser Phe Gly Pro Glu Met Pro 
1               5                   10                  15      


Ala Val Gln Leu Leu Leu Leu Ala Cys Leu Val Trp Asp Val Gly Ala 
            20                  25                  30          


Arg Thr Ala Gln Leu Arg Lys Ala Asn Asp Gln Ser Gly Arg Cys Gln 
        35                  40                  45              


Tyr Thr Phe Ser Val Ala Ser Pro Asn Glu Ser Ser Cys Pro Glu Gln 
    50                  55                  60                  


Ser Gln Ala Met Ser Val Ile His Asn Leu Gln Arg Asp Ser Ser Thr 
65                  70                  75                  80  


Gln Arg Leu Asp Leu Glu Ala Thr Lys Ala Arg Leu Ser Ser Leu Glu 
                85                  90                  95      


Ser Leu Leu His Gln Leu Thr Leu Asp Gln Ala Ala Arg Pro Gln Glu 
            100                 105                 110         


Thr Gln Glu Gly Leu Gln Arg Glu Leu Gly Thr Leu Arg Arg Glu Arg 
        115                 120                 125             


Asp Gln Leu Glu Thr Gln Thr Arg Glu Leu Glu Thr Ala Tyr Ser Asn 
    130                 135                 140                 


Leu Leu Arg Asp Lys Ser Val Leu Glu Glu Glu Lys Lys Arg Leu Arg 
145                 150                 155                 160 


Gln Glu Asn Glu Asn Leu Ala Arg Arg Leu Glu Ser Ser Ser Gln Glu 
                165                 170                 175     


Val Ala Arg Leu Arg Arg Gly Gln Cys Pro Gln Thr Arg Asp Thr Ala 
            180                 185                 190         


Arg Ala Val Pro Pro Gly Ser Arg Glu Val Ser Thr Trp Asn Leu Asp 
        195                 200                 205             


Thr Leu Ala Phe Gln Glu Leu Lys Ser Glu Leu Thr Glu Val Pro Ala 
    210                 215                 220                 


Ser Arg Ile Leu Lys Glu Ser Pro Ser Gly Tyr Leu Arg Ser Gly Glu 
225                 230                 235                 240 


Gly Asp Thr Gly Cys Gly Glu Leu Val Trp Val Gly Glu Pro Leu Thr 
                245                 250                 255     


Leu Arg Thr Ala Glu Thr Ile Thr Gly Lys Tyr Gly Val Trp Met Arg 
            260                 265                 270         


Asp Pro Lys Pro Thr Tyr Pro Tyr Thr Gln Glu Thr Thr Trp Arg Ile 
        275                 280                 285             


Asp Thr Val Gly Thr Asp Val Arg Gln Val Phe Glu Tyr Asp Leu Ile 
    290                 295                 300                 


Ser Gln Phe Met Gln Gly Tyr Pro Ser Lys Val His Ile Leu Pro Arg 
305                 310                 315                 320 


Pro Leu Glu Ser Thr Gly Ala Val Val Tyr Ser Gly Ser Leu Tyr Phe 
                325                 330                 335     


Gln Gly Ala Glu Ser Arg Thr Val Ile Arg Tyr Glu Leu Asn Thr Glu 
            340                 345                 350         


Thr Val Lys Ala Glu Lys Glu Ile Pro Gly Ala Gly Tyr His Gly Gln 
        355                 360                 365             


Phe Pro Tyr Ser Trp Gly Gly Tyr Thr Asp Ile Asp Leu Ala Val Asp 
    370                 375                 380                 


Glu Ala Gly Leu Trp Val Ile Tyr Ser Thr Asp Glu Ala Lys Gly Ala 
385                 390                 395                 400 


Ile Val Leu Ser Lys Leu Asn Pro Glu Asn Leu Glu Leu Glu Gln Thr 
                405                 410                 415     


Trp Glu Thr Asn Ile Arg Lys Gln Ser Val Ala Asn Ala Phe Ile Ile 
            420                 425                 430         


Cys Gly Thr Leu Tyr Thr Val Ser Ser Tyr Thr Ser Ala Asp Ala Thr 
        435                 440                 445             


Val Asn Phe Ala Tyr Asp Thr Gly Thr Gly Ile Ser Lys Thr Leu Thr 
    450                 455                 460                 


Ile Pro Phe Lys Asn Arg Tyr Lys Tyr Ser Ser Met Ile Asp Tyr Asn 
465                 470                 475                 480 


Pro Leu Glu Lys Lys Leu Phe Ala Trp Asp Asn Leu Asn Met Val Thr 
                485                 490                 495     


Tyr Asp Ile Lys Leu Ser Lys Met 
            500                 


<210>  9134
<211>  250
<212>  PRT
<213>  Homo Sapiens

<400>  9134

Met Ala Phe Cys Ala Leu Thr Ile Val Ala Leu Tyr Ile Leu Ser Leu 
1               5                   10                  15      


Lys Asp Gln Asp Arg Arg Val Pro Asn Leu Pro Pro Ser Asn Ile Thr 
            20                  25                  30          


Ser Ser Gln Glu Pro Ala Leu Leu Pro Thr Ala Ser Ser Ser Ala Pro 
        35                  40                  45              


Asn Thr Ser Leu Val Thr Thr Pro Ala Ser Leu Gln Val Pro Glu Ile 
    50                  55                  60                  


Thr Phe Cys Glu Ile Leu Pro Cys Gln Glu Thr Tyr Cys Cys Pro Ile 
65                  70                  75                  80  


Arg Gly Met Lys Glu Val Ser Ser Ser Pro Val Gln Arg Gln Ser Glu 
                85                  90                  95      


Glu Lys Glu Phe His Gln Arg Arg Trp Ser Glu Asp Lys Ser Lys Ser 
            100                 105                 110         


Val Leu Ala Arg Asn Ala Leu Ser Gly Pro Asp Trp Glu Ser Asp Trp 
        115                 120                 125             


Ile Asp Thr Thr Ile Ser Ser Ile Gln Ile Met Glu Ile Gln Gln Ile 
    130                 135                 140                 


Ile Asp His Gln Tyr Cys Ile Gln Ser Leu Gln Cys Gly Thr Thr Glu 
145                 150                 155                 160 


Pro Leu Ile Val Phe Gln Cys Lys Phe Thr Leu Gly Asn Ile Cys Phe 
                165                 170                 175     


His Ser Lys Arg Gly Thr Lys Gly Leu Glu Ser His Arg Glu Ile Ser 
            180                 185                 190         


Gln Glu Met Thr Gln Gly Tyr Gln His Ile Trp Ser Leu Pro Val Ala 
        195                 200                 205             


Pro Phe Ser Asp Ser Met Phe His Phe Arg Val Ala Ala Pro Asp Leu 
    210                 215                 220                 


Ala Asp Cys Ser Thr Asp Pro Tyr Phe Ala Gly Ile Phe Phe Thr Asp 
225                 230                 235                 240 


Tyr Phe Phe Tyr Phe Tyr Arg Arg Cys Ala 
                245                 250 


<210>  9135
<211>  898
<212>  PRT
<213>  Homo Sapiens

<400>  9135

Met Asp Val Val Gly Glu Asn Glu Ala Leu Gln Gln Phe Phe Glu Ala 
1               5                   10                  15      


Gln Gly Ala Asn Gly Thr Leu Glu Asn Pro Ala Leu Asp Thr Ser Leu 
            20                  25                  30          


Leu Glu Glu Phe Leu Gly Asn Asp Phe Asp Leu Gly Ala Leu Gln Arg 
        35                  40                  45              


Gln Leu Pro Asp Thr Pro Pro Tyr Ser Ala Ser Asp Ser Cys Ser Pro 
    50                  55                  60                  


Pro Gln Val Lys Gly Ala Cys Tyr Pro Thr Leu Arg Pro Thr Ala Gly 
65                  70                  75                  80  


Arg Thr Pro Ala Pro Phe Leu His Pro Thr Ala Ala Pro Ala Met Pro 
                85                  90                  95      


Pro Met His Pro Leu Gln Ser Thr Ser Gly Met Gly Asp Ser Cys Gln 
            100                 105                 110         


Ile His Gly Gly Phe His Ser Cys His Ser Asn Ala Ser His Leu Ala 
        115                 120                 125             


Thr Pro Leu Asp Gln Ser Val Ser Ser His Leu Gly Ile Gly Cys Ser 
    130                 135                 140                 


Tyr Pro Gln Gln Pro Leu Cys His Ser Pro Gly Ala Ser Leu Pro Pro 
145                 150                 155                 160 


Thr Lys Lys Arg Lys Cys Thr Gln Ala Leu Glu Asp Ser Gly Glu Cys 
                165                 170                 175     


Arg Val Trp Ala Cys His Cys Arg Pro Met Thr Ser Arg Ser Arg Ser 
            180                 185                 190         


Ser Glu Val Gln Asp Pro Asp Ser Glu Gly Gln Asn Arg Met Pro Thr 
        195                 200                 205             


Asp Gln Cys Ser Pro Ala Leu Lys Trp Gln Pro Cys His Ser Val Pro 
    210                 215                 220                 


Trp His Ser Leu Leu Asn Ser His Tyr Glu Lys Leu Pro Asp Val Gly 
225                 230                 235                 240 


Tyr Arg Val Val Thr Asp Lys Gly Phe Asn Phe Ser Pro Ala Asp Glu 
                245                 250                 255     


Ala Phe Val Cys Gln Lys Lys Asn His Phe Gln Ile Thr Ile His Ile 
            260                 265                 270         


Gln Val Trp Gly Ser Pro Lys Phe Val Glu Thr Glu Met Gly Leu Lys 
        275                 280                 285             


Pro Ile Glu Met Phe Tyr Leu Lys Val Phe Gly Thr Lys Val Glu Ala 
    290                 295                 300                 


Thr Asn Gln Ile Ile Ala Ile Glu Gln Ser Gln Ala Asp Arg Ser Lys 
305                 310                 315                 320 


Lys Ile Phe Asn Pro Val Lys Ile Asp Leu Leu Ala Asp Gln Val Thr 
                325                 330                 335     


Lys Val Thr Leu Gly Arg Leu His Phe Ser Glu Thr Thr Ala Asn Asn 
            340                 345                 350         


Met Arg Lys Lys Gly Lys Pro Asn Pro Asp Gln Arg Tyr Phe Met Leu 
        355                 360                 365             


Val Val Gly Leu Tyr Ala Ala Asn Gln Asp Gln Phe Tyr Leu Leu Ser 
    370                 375                 380                 


Ala His Ile Ser Glu Arg Ile Ile Val Arg Ala Ser Asn Pro Gly Gln 
385                 390                 395                 400 


Phe Glu Asn Asp Ser Asp Ala Leu Trp Gln Arg Gly Gln Val Pro Glu 
                405                 410                 415     


Ser Ile Val Cys His Gly Arg Val Gly Ile Asn Thr Asp Ala Pro Asp 
            420                 425                 430         


Glu Ala Leu Val Val Cys Gly Asn Met Lys Val Met Gly Thr Ile Met 
        435                 440                 445             


His Pro Ser Asp Ser Arg Ala Lys Gln Asn Ile Gln Glu Val Asp Thr 
    450                 455                 460                 


Asn Glu Gln Leu Lys Arg Ile Ala Gln Met Arg Ile Val Glu Tyr Asp 
465                 470                 475                 480 


Tyr Lys Pro Glu Phe Ala Ser Ala Met Gly Ile Asn Thr Ala His Gln 
                485                 490                 495     


Thr Gly Met Ile Ala Gln Glu Val Gln Glu Ile Leu Pro Arg Ala Val 
            500                 505                 510         


Arg Glu Val Gly Asp Val Thr Cys Gly Asn Gly Glu Thr Leu Glu Asn 
        515                 520                 525             


Phe Leu Met Val Asp Lys Asp Gln Ile Phe Met Glu Asn Val Gly Ala 
    530                 535                 540                 


Val Lys Gln Leu Cys Lys Leu Thr Asn Asn Leu Glu Glu Arg Ile Glu 
545                 550                 555                 560 


Glu Leu Glu Ile Trp Asn Arg Lys Leu Ala Arg Leu Lys Arg Leu Ser 
                565                 570                 575     


Ser Trp Lys Ser Ser Ala Ser Glu Ala Ser Thr Ile Ser Lys Ser Ser 
            580                 585                 590         


Arg Ala Val Ser Ala Ser Ser Pro Arg Arg Ala Val His Lys Lys Asn 
        595                 600                 605             


Asn Lys Val Tyr Phe Ser Gly Lys Arg Gln Ala Cys Pro Asn Trp Val 
    610                 615                 620                 


Phe Gln Thr Leu Val Ile Thr Leu Ile Ala Val Met Ala Phe Cys Leu 
625                 630                 635                 640 


Lys Asp Gln Asp Arg Arg Val Pro Asn Leu Pro Pro Ser Asn Ile Thr 
                645                 650                 655     


Ser Ser Gln Glu Pro Ala Leu Leu Pro Thr Ala Ser Ser Ser Ala Pro 
            660                 665                 670         


Asn Thr Ser Leu Val Thr Thr Pro Ala Ser Leu Gln Val Pro Glu Ile 
        675                 680                 685             


Thr Phe Cys Glu Ile Leu Pro Cys Gln Glu Thr Tyr Cys Cys Pro Ile 
    690                 695                 700                 


Arg Gly Met Lys Glu Val Ser Ser Ser Pro Val Gln Arg Gln Ser Glu 
705                 710                 715                 720 


Glu Lys Glu Phe His Gln Arg Arg Trp Ser Asp Lys Ser Lys Ser Val 
                725                 730                 735     


Leu Ala Arg Asn Ala Leu Ser Gly Pro Asp Trp Glu Ser Asp Trp Ile 
            740                 745                 750         


Asp Thr Thr Ile Ser Ser Ile Gln Ile Met Glu Ile Gln Gln Ile Ile 
        755                 760                 765             


Asp His Gln Tyr Cys Ile Gln Ser Leu Gln Cys Gly Ser Gly Asn Tyr 
    770                 775                 780                 


Asn Tyr Asn Ile Pro Val Asn Lys His Thr Pro Thr Asn Val Lys Phe 
785                 790                 795                 800 


Ser Leu Glu Ile Asn Thr Thr Glu Pro Leu Ile Val Phe Gln Cys Lys 
                805                 810                 815     


Phe Thr Leu Gly Asn Ile Cys Phe His Ser Lys Arg Gly Thr Lys Gly 
            820                 825                 830         


Leu Glu Ser His Arg Glu Ile Ser Gln Glu Met Thr Gln Gly Tyr Gln 
        835                 840                 845             


His Ile Trp Ser Leu Pro Val Ala Pro Phe Ser Asp Ser Met Phe His 
    850                 855                 860                 


Phe Arg Val Ala Ala Pro Asp Leu Ala Asp Cys Ser Thr Asp Pro Tyr 
865                 870                 875                 880 


Phe Ala Gly Ile Phe Phe Thr Asp Tyr Phe Phe Tyr Phe Tyr Arg Arg 
                885                 890                 895     


Cys Ala 
        


<210>  9136
<211>  910
<212>  PRT
<213>  Homo Sapiens

<400>  9136

Met Asp Val Val Gly Glu Asn Glu Ala Leu Gln Gln Phe Phe Glu Ala 
1               5                   10                  15      


Gln Gly Ala Asn Gly Thr Leu Glu Asn Pro Ala Leu Asp Thr Ser Leu 
            20                  25                  30          


Leu Glu Glu Phe Leu Gly Asn Asp Phe Asp Leu Gly Ala Leu Gln Arg 
        35                  40                  45              


Gln Leu Pro Asp Thr Pro Pro Tyr Ser Ala Ser Asp Ser Cys Ser Pro 
    50                  55                  60                  


Pro Gln Val Lys Gly Ala Cys Tyr Pro Thr Leu Arg Pro Thr Ala Gly 
65                  70                  75                  80  


Arg Thr Pro Ala Pro Phe Leu His Pro Thr Ala Ala Pro Ala Met Pro 
                85                  90                  95      


Pro Met His Pro Leu Gln Ser Thr Ser Gly Met Gly Asp Ser Cys Gln 
            100                 105                 110         


Ile His Gly Gly Phe His Ser Cys His Ser Asn Ala Ser His Leu Ala 
        115                 120                 125             


Thr Pro Leu Asp Gln Ser Val Ser Ser His Leu Gly Ile Gly Cys Ser 
    130                 135                 140                 


Tyr Pro Gln Gln Pro Leu Cys His Ser Pro Gly Ala Ser Leu Pro Pro 
145                 150                 155                 160 


Thr Lys Lys Arg Lys Cys Thr Gln Ala Leu Glu Asp Ser Gly Glu Cys 
                165                 170                 175     


Arg Val Trp Ala Cys His Cys Arg Pro Met Thr Ser Arg Ser Arg Ser 
            180                 185                 190         


Ser Glu Val Gln Asp Pro Asp Ser Glu Gly Gln Asn Arg Met Pro Thr 
        195                 200                 205             


Asp Gln Cys Ser Pro Ala Leu Lys Trp Gln Pro Cys His Ser Val Pro 
    210                 215                 220                 


Trp His Ser Leu Leu Asn Ser His Tyr Glu Lys Leu Pro Asp Val Gly 
225                 230                 235                 240 


Tyr Arg Val Val Thr Asp Lys Gly Phe Asn Phe Ser Pro Ala Asp Glu 
                245                 250                 255     


Ala Phe Val Cys Gln Lys Lys Asn His Phe Gln Ile Thr Ile His Ile 
            260                 265                 270         


Gln Val Trp Gly Ser Pro Lys Phe Val Glu Thr Glu Met Gly Leu Lys 
        275                 280                 285             


Pro Ile Glu Met Phe Tyr Leu Lys Val Phe Gly Thr Lys Val Glu Ala 
    290                 295                 300                 


Thr Asn Gln Ile Ile Ala Ile Glu Gln Ser Gln Ala Asp Arg Ser Lys 
305                 310                 315                 320 


Lys Ile Phe Asn Pro Val Lys Ile Asp Leu Leu Ala Asp Gln Val Thr 
                325                 330                 335     


Lys Val Thr Leu Gly Arg Leu His Phe Ser Glu Thr Thr Ala Asn Asn 
            340                 345                 350         


Met Arg Lys Lys Gly Lys Pro Asn Pro Asp Gln Arg Tyr Phe Met Leu 
        355                 360                 365             


Val Val Gly Leu Tyr Ala Ala Asn Gln Asp Gln Phe Tyr Leu Leu Ser 
    370                 375                 380                 


Ala His Ile Ser Glu Arg Ile Ile Val Arg Ala Ser Asn Pro Gly Gln 
385                 390                 395                 400 


Phe Glu Asn Asp Ser Asp Ala Leu Trp Gln Arg Gly Gln Val Pro Glu 
                405                 410                 415     


Ser Ile Val Cys His Gly Arg Val Gly Ile Asn Thr Asp Ala Pro Asp 
            420                 425                 430         


Glu Ala Leu Val Val Cys Gly Asn Met Lys Val Met Gly Thr Ile Met 
        435                 440                 445             


His Pro Ser Asp Ser Arg Ala Lys Gln Asn Ile Gln Glu Val Asp Thr 
    450                 455                 460                 


Asn Glu Gln Leu Lys Arg Ile Ala Gln Met Arg Ile Val Glu Tyr Asp 
465                 470                 475                 480 


Tyr Lys Pro Glu Phe Ala Ser Ala Met Gly Ile Asn Thr Ala His Gln 
                485                 490                 495     


Thr Gly Met Ile Ala Gln Glu Val Gln Glu Ile Leu Pro Arg Ala Val 
            500                 505                 510         


Arg Glu Val Gly Asp Val Thr Cys Gly Asn Gly Glu Thr Leu Glu Asn 
        515                 520                 525             


Phe Leu Met Val Asp Lys Asp Gln Ile Phe Met Glu Asn Val Gly Ala 
    530                 535                 540                 


Val Lys Gln Leu Cys Lys Leu Thr Asn Asn Leu Glu Glu Arg Ile Glu 
545                 550                 555                 560 


Glu Leu Glu Ile Trp Asn Arg Lys Leu Ala Arg Leu Lys Arg Leu Ser 
                565                 570                 575     


Ser Trp Lys Ser Ser Ala Ser Glu Ala Ser Thr Ile Ser Lys Ser Ser 
            580                 585                 590         


Arg Ala Val Ser Ala Ser Ser Pro Arg Arg Ala Val His Lys Lys Asn 
        595                 600                 605             


Asn Lys Val Tyr Phe Ser Gly Lys Arg Gln Ala Cys Pro Asn Trp Val 
    610                 615                 620                 


Phe Gln Thr Leu Val Ile Thr Leu Ile Ala Val Met Ala Phe Cys Ala 
625                 630                 635                 640 


Leu Thr Ile Val Ala Leu Tyr Ile Leu Ser Leu Lys Asp Gln Asp Arg 
                645                 650                 655     


Arg Val Pro Asn Leu Pro Pro Ser Asn Ile Thr Ser Ser Gln Glu Pro 
            660                 665                 670         


Ala Leu Leu Pro Thr Ala Ser Ser Ser Ala Pro Asn Thr Ser Leu Val 
        675                 680                 685             


Thr Thr Pro Ala Ser Leu Gln Val Pro Glu Ile Thr Phe Cys Glu Ile 
    690                 695                 700                 


Leu Pro Cys Gln Glu Thr Tyr Cys Cys Pro Ile Arg Gly Met Lys Glu 
705                 710                 715                 720 


Val Ser Ser Ser Pro Val Gln Arg Gln Ser Glu Glu Lys Glu Phe His 
                725                 730                 735     


Gln Arg Arg Trp Ser Glu Asp Lys Ser Lys Ser Val Leu Ala Arg Asn 
            740                 745                 750         


Ala Leu Ser Gly Pro Asp Trp Glu Ser Asp Trp Ile Asp Thr Thr Ile 
        755                 760                 765             


Ser Ser Ile Gln Ile Met Glu Ile Gln Gln Ile Ile Asp His Gln Tyr 
    770                 775                 780                 


Cys Ile Gln Ser Leu Gln Cys Gly Ser Gly Asn Tyr Asn Tyr Asn Ile 
785                 790                 795                 800 


Pro Val Asn Lys His Thr Pro Thr Asn Val Lys Phe Ser Leu Glu Ile 
                805                 810                 815     


Asn Thr Thr Glu Pro Leu Ile Val Phe Gln Cys Lys Phe Thr Leu Gly 
            820                 825                 830         


Asn Ile Cys Phe His Ser Lys Arg Gly Thr Lys Gly Leu Glu Ser His 
        835                 840                 845             


Arg Glu Ile Ser Gln Glu Met Thr Gln Gly Tyr Gln His Ile Trp Ser 
    850                 855                 860                 


Leu Pro Val Ala Pro Phe Ser Asp Ser Met Phe His Phe Arg Val Ala 
865                 870                 875                 880 


Ala Pro Asp Leu Ala Asp Cys Ser Thr Asp Pro Tyr Phe Ala Gly Ile 
                885                 890                 895     


Phe Phe Thr Asp Tyr Phe Phe Tyr Phe Tyr Arg Arg Cys Ala 
            900                 905                 910 


<210>  9137
<211>  250
<212>  PRT
<213>  Homo Sapiens

<400>  9137

Met Val Phe Leu Ala Leu Thr Ile Val Ala Leu Tyr Ile Leu Ser Leu 
1               5                   10                  15      


Lys Asp Gln Asp Arg Arg Val Pro Asn Leu Pro Pro Ser Asn Ile Thr 
            20                  25                  30          


Ser Ser Gln Glu Pro Ala Leu Leu Pro Thr Ala Ser Ser Ser Ala Pro 
        35                  40                  45              


Asn Thr Ser Leu Val Thr Thr Pro Ala Ser Leu Gln Val Pro Glu Ile 
    50                  55                  60                  


Thr Phe Cys Glu Ile Leu Pro Cys Gln Glu Thr Tyr Cys Cys Pro Ile 
65                  70                  75                  80  


Arg Gly Met Lys Glu Val Ser Ser Ser Pro Val Gln Arg Gln Ser Glu 
                85                  90                  95      


Glu Lys Glu Phe His Gln Arg Arg Trp Ser Glu Asp Lys Ser Lys Ser 
            100                 105                 110         


Val Leu Ala Arg Asn Ala Leu Ser Gly Pro Asp Trp Glu Ser Asp Trp 
        115                 120                 125             


Ile Asp Thr Thr Ile Ser Ser Ile Gln Ile Met Glu Ile Gln Gln Ile 
    130                 135                 140                 


Ile Asp His Gln Tyr Cys Ile Gln Ser Leu Gln Cys Gly Thr Thr Glu 
145                 150                 155                 160 


Pro Leu Ile Val Phe Gln Cys Lys Phe Thr Leu Gly Asn Ile Cys Phe 
                165                 170                 175     


His Ser Lys Arg Gly Thr Lys Gly Leu Glu Ser His Arg Glu Ile Ser 
            180                 185                 190         


Gln Glu Met Thr Gln Gly Tyr Gln His Ile Trp Ser Leu Pro Val Ala 
        195                 200                 205             


Pro Phe Ser Asp Ser Met Phe His Phe Arg Val Ala Ala Pro Asp Leu 
    210                 215                 220                 


Ala Asp Cys Ser Thr Asp Pro Tyr Phe Ala Gly Ile Phe Phe Thr Asp 
225                 230                 235                 240 


Tyr Phe Phe Tyr Phe Tyr Arg Arg Cys Ala 
                245                 250 


<210>  9138
<211>  375
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9138

Xaa Ile Phe Met Glu Asn Val Gly Ala Val Lys Gln Leu Cys Lys Leu 
1               5                   10                  15      


Thr Asn Asn Leu Glu Glu Arg Ile Glu Glu Leu Glu Ile Trp Asn Arg 
            20                  25                  30          


Lys Leu Ala Arg Leu Lys Arg Leu Ser Ser Trp Lys Ser Ser Ala Ser 
        35                  40                  45              


Glu Ala Ser Thr Ile Ser Lys Ser Ser Arg Ala Val Ser Ala Ser Ser 
    50                  55                  60                  


Pro Arg Arg Ala Val His Lys Lys Asn Asn Lys Val Tyr Phe Ser Gly 
65                  70                  75                  80  


Lys Arg Gln Ala Cys Pro Asn Trp Val Phe Gln Thr Leu Val Ile Thr 
                85                  90                  95      


Leu Ile Ala Val Met Ala Phe Cys Ala Leu Thr Ile Val Ala Leu Tyr 
            100                 105                 110         


Ile Leu Ser Leu Lys Asp Gln Asp Arg Arg Val Pro Asn Leu Pro Pro 
        115                 120                 125             


Ser Asn Ile Thr Ser Ser Gln Glu Pro Ala Leu Leu Pro Thr Ala Ser 
    130                 135                 140                 


Ser Ser Ala Pro Asn Thr Ser Leu Val Thr Thr Pro Ala Ser Leu Gln 
145                 150                 155                 160 


Val Pro Glu Ile Thr Phe Cys Glu Ile Leu Pro Cys Gln Glu Thr Tyr 
                165                 170                 175     


Cys Cys Pro Ile Arg Gly Met Lys Glu Val Ser Ser Ser Pro Val Gln 
            180                 185                 190         


Arg Gln Ser Glu Glu Lys Glu Phe His Gln Arg Arg Trp Ser Glu Asp 
        195                 200                 205             


Lys Ser Lys Ser Val Leu Ala Arg Asn Ala Leu Ser Gly Pro Asp Trp 
    210                 215                 220                 


Glu Ser Asp Trp Ile Asp Thr Thr Ile Ser Ser Ile Gln Ile Met Glu 
225                 230                 235                 240 


Ile Gln Gln Ile Ile Asp His Gln Tyr Cys Ile Gln Ser Leu Gln Cys 
                245                 250                 255     


Gly Ser Gly Asn Tyr Asn Tyr Asn Ile Pro Val Asn Lys His Thr Pro 
            260                 265                 270         


Thr Asn Val Lys Phe Ser Leu Glu Ile Asn Thr Thr Glu Pro Leu Ile 
        275                 280                 285             


Val Phe Gln Cys Lys Phe Thr Leu Gly Asn Ile Cys Phe His Ser Lys 
    290                 295                 300                 


Arg Gly Thr Lys Gly Leu Glu Ser His Arg Glu Ile Ser Gln Glu Met 
305                 310                 315                 320 


Thr Gln Gly Tyr Gln His Ile Trp Ser Leu Pro Val Ala Pro Phe Ser 
                325                 330                 335     


Asp Ser Met Phe His Phe Arg Val Ala Ala Pro Asp Leu Ala Asp Cys 
            340                 345                 350         


Ser Thr Asp Pro Tyr Phe Ala Gly Ile Phe Phe Thr Asp Tyr Phe Phe 
        355                 360                 365             


Tyr Phe Tyr Arg Arg Cys Ala 
    370                 375 


<210>  9139
<211>  76
<212>  PRT
<213>  Homo Sapiens

<400>  9139

Met Arg Leu Ser Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Trp Ala 
1               5                   10                  15      


Ile Pro Gly Gly Leu Gly Asp Arg Ala Pro Leu Thr Ala Thr Ala Pro 
            20                  25                  30          


Gln Leu Asp Asp Glu Glu Met Tyr Ser Ala His Met Pro Ala His Leu 
        35                  40                  45              


Arg Cys Asp Ala Cys Arg Ala Val Ala Tyr Gln Leu Arg Ser Ser Arg 
    50                  55                  60                  


Ser Gly Pro Ser Glu Thr Ser His Arg Pro Arg Thr 
65                  70                  75      


<210>  9140
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  9140

Met Arg Leu Ser Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Trp Ala 
1               5                   10                  15      


Ile Pro Gly Gly Leu Gly Asp Arg Ala Pro Leu Thr Ala Thr Ala Pro 
            20                  25                  30          


Gln Leu Asp Asp Glu Glu Met Tyr Ser Ala His Met Pro Ala His Leu 
        35                  40                  45              


Arg Cys Asp Ala Cys Arg Ala Val Ala Tyr Gln Met Trp Gln Asn Leu 
    50                  55                  60                  


Ala Lys Ala Glu Thr Lys Leu His Thr Ser Asn Ser Gly Gly Arg Arg 
65                  70                  75                  80  


Glu Leu Ser Glu Leu Val Tyr Thr Asp Val Leu Asp Arg Ser Cys Ser 
                85                  90                  95      


Arg Asn Trp Gln Asp Tyr Gly Val Arg Glu Val Asp Gln Val Lys Arg 
            100                 105                 110         


Leu Thr Gly Pro Gly Leu Ser Glu Gly Pro Glu Pro Ser Ile Ser Val 
        115                 120                 125             


Met Val Thr Gly Gly Pro Trp Pro Thr Arg Leu Ser Arg Thr Cys Leu 
    130                 135                 140                 


His Tyr Leu Gly Glu Phe Gly Glu Asp Gln Ile Tyr Glu Ala His Gln 
145                 150                 155                 160 


Gln Gly Arg Gly Ala Leu Glu Ala Leu Leu Cys Gly Gly Pro Gln Gly 
                165                 170                 175     


Ala Cys Ser Glu Lys Val Ser Ala Thr Arg Glu Glu Leu 
            180                 185                 


<210>  9141
<211>  75
<212>  PRT
<213>  Homo Sapiens

<400>  9141

Met Arg Leu Ser Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Trp Ala 
1               5                   10                  15      


Ile Pro Gly Gly Leu Gly Asp Arg Ala Pro Leu Thr Ala Thr Ala Pro 
            20                  25                  30          


Gln Leu Asp Asp Glu Glu Met Tyr Ser Ala His Met Pro Ala His Leu 
        35                  40                  45              


Arg Cys Asp Ala Cys Arg Ala Val Ala Tyr Gln Arg Leu Cys Ser Tyr 
    50                  55                  60                  


Pro Pro His Leu Pro Leu Thr Glu Gln Gln Ser 
65                  70                  75  


<210>  9142
<211>  123
<212>  PRT
<213>  Homo Sapiens

<400>  9142

Met Arg Leu Ser Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Trp Ala 
1               5                   10                  15      


Ile Pro Gly Gly Leu Gly Asp Arg Ala Pro Leu Thr Ala Thr Ala Pro 
            20                  25                  30          


Gln Leu Asp Asp Glu Glu Met Tyr Ser Ala His Met Pro Ala His Leu 
        35                  40                  45              


Arg Cys Asp Ala Cys Arg Ala Val Ala Tyr Gln Ser Leu Leu Val Pro 
    50                  55                  60                  


Asp Val Ala Lys Ser Gly Lys Gly Arg Asp Gln Thr Ser Tyr Leu Lys 
65                  70                  75                  80  


Leu Trp Gly Ala Ala Gly Ala Glu Arg Val Gly Leu His Gly Cys Pro 
                85                  90                  95      


Gly Pro Glu Leu Leu Pro Glu Leu Ala Gly Leu Arg Ser Ser Arg Ser 
            100                 105                 110         


Gly Pro Ser Glu Thr Ser His Arg Pro Arg Thr 
        115                 120             


<210>  9143
<211>  60
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9143

Xaa Ser Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Trp Ala Ile Pro 
1               5                   10                  15      


Gly Gly Leu Gly Asp Arg Ala Pro Leu Thr Ala Thr Ala Pro Gln Leu 
            20                  25                  30          


Asp Asp Glu Glu Met Tyr Ser Ala His Met Pro Ala His Leu Arg Cys 
        35                  40                  45              


Asp Ala Cys Arg Ala Val Ala Tyr Gln Ala His Pro 
    50                  55                  60  


<210>  9144
<211>  737
<212>  PRT
<213>  Homo Sapiens

<400>  9144

Met Ala Leu Cys Ser Ala Leu Met Thr Ile Phe Thr Ile Lys Met Gly 
1               5                   10                  15      


Thr Ala Lys Gln Ala Ile Asp Gln Gly Arg Ser Pro Val Ile Ile Asp 
            20                  25                  30          


Asn Thr Asn Ile Gln Ala Trp Glu Met Lys Pro Tyr Val Glu Val Ala 
        35                  40                  45              


Ile Gly Lys Gly Tyr Arg Val Glu Phe His Glu Pro Glu Thr Trp Trp 
    50                  55                  60                  


Lys Phe Asp Pro Glu Glu Leu Glu Lys Arg Asn Lys His Gly Val Ser 
65                  70                  75                  80  


Arg Lys Lys Ile Ala Gln Met Leu Asp Arg Tyr Glu Tyr Gln Met Ser 
                85                  90                  95      


Ile Ser Ile Val Met Asn Ser Val Glu Pro Ser His Lys Ser Thr Gln 
            100                 105                 110         


Arg Pro Pro Pro Pro Gln Gly Arg Gln Arg Glu Arg Val Leu Lys Lys 
        115                 120                 125             


Thr Gly His Arg Leu Ser Lys Thr Lys Gln Lys Arg Asn Arg Lys Arg 
    130                 135                 140                 


Asn Lys Lys Gln Asn Ser Gln Asn Arg Ile Met Glu Glu Asn Ser Leu 
145                 150                 155                 160 


Glu Phe Leu Ser Asp Leu Thr Pro Gly Asp Gln Asp Pro Ser Gln Ser 
                165                 170                 175     


Glu Glu Glu Asp Ile Glu Lys Thr Arg Arg Glu Ser Glu Tyr Pro Phe 
            180                 185                 190         


Ile Asp Gly Leu Gln Asn Glu Val Gly Asp Phe Val Thr Gly Tyr Lys 
        195                 200                 205             


Glu Lys Arg Trp Lys Asn Lys Asp Pro Lys Asp Ser Phe Gln Asn Val 
    210                 215                 220                 


Met Ser Ile Val Glu Leu Asp Asn Thr Pro Lys Asn Tyr Leu Ser Lys 
225                 230                 235                 240 


Glu Gly Asp Asn Leu Phe Val Ser Leu Leu Leu Arg Pro Asn Glu Ile 
                245                 250                 255     


Ser Val Thr Cys Pro Ile Leu Thr Gln Asn Leu Ser Cys Val Thr Thr 
            260                 265                 270         


Asp Asp Cys Ser Gly Met Lys Val Glu Lys His Ile Arg Asn Arg His 
        275                 280                 285             


Thr Ile Ala Leu Asp Thr Gln Asp Leu Ser Ala Glu Thr Ser Cys Leu 
    290                 295                 300                 


Phe Met Lys Lys Arg Glu Ile Val Asp Lys Asn Leu Ser His Glu Pro 
305                 310                 315                 320 


Ile Leu Cys His Gln His Gly Ile Arg Met Ser Asp Lys Val Leu Arg 
                325                 330                 335     


Glu Glu Gln Val Tyr Thr Thr Lys Ile Asn His Trp Ala Phe Phe Thr 
            340                 345                 350         


Thr Asn Leu Ser Asp Glu Asp Leu Gln Leu Gly Ser Asp Arg Gln Pro 
        355                 360                 365             


Tyr Phe Gly Ser Trp Pro Ala Gly Pro His Lys Phe Ile Cys Glu Gln 
    370                 375                 380                 


Arg Pro Lys Lys Asp Arg Ala Cys Lys Leu Ala Gly Pro Asp Ser Arg 
385                 390                 395                 400 


Gly Gln Trp Ile Gln Met Ile Phe Thr Ser Val Ala Ala Ser Glu Pro 
                405                 410                 415     


Gly Asn Asn Pro Glu Ile Leu Thr Asp Lys Leu Leu Ile Gly Asn Glu 
            420                 425                 430         


Asp Phe Ser Pro Pro Pro Glu Thr Met Asp Ser Phe Ile Glu Thr Asn 
        435                 440                 445             


Leu Phe Arg Ser Cys Leu Pro Gln Pro Asp Ile Pro Lys Asn Ala Leu 
    450                 455                 460                 


Glu Ser Thr Lys Asn Lys Lys Arg Arg Lys Lys Arg Ile Phe Asn Leu 
465                 470                 475                 480 


Val Pro Asn Phe Asp Leu Leu Gly Gln Ser Arg Ile Gly Val Lys Glu 
                485                 490                 495     


Arg Glu Lys Cys Asp Leu Leu Thr Lys Asn His Gly Leu Lys Ile Thr 
            500                 505                 510         


Leu Gly Glu Glu Lys Asp Arg Ile Ser Glu Arg Asn Ser Glu Glu Glu 
        515                 520                 525             


Asn Lys Gln Lys Leu Met Thr Phe Asp His His Pro Leu Trp Phe Tyr 
    530                 535                 540                 


Leu Asp Ile Ile Lys Ala Thr Pro Leu Asn Ile Asp Gly Gln Arg Tyr 
545                 550                 555                 560 


Ser His Cys Leu Ser Phe Asn Arg Leu Arg Cys Ser Ala Ser Leu Tyr 
                565                 570                 575     


Lys Asn Tyr Ile Pro Ser Phe Val Leu His Asn Leu Ser Ser Ile Trp 
            580                 585                 590         


Lys Pro Ser Phe Thr Asn Lys Lys Leu Phe Leu Thr Phe Glu Ser Gln 
        595                 600                 605             


Thr Arg Val Gly Asn Lys Leu Asn Asp Ala Gly Phe Ile Ser Pro Glu 
    610                 615                 620                 


Ile Leu His Ser His Pro Asp Thr Ser Cys Ser Leu Gly Val Thr Ser 
625                 630                 635                 640 


Asp Phe His Phe Leu Asn Glu Arg Phe Asp Arg Lys Leu Lys Arg Trp 
                645                 650                 655     


Glu Glu Pro Lys Glu Leu Pro Ala Glu Asp Ser Gln Asp Leu Thr Ser 
            660                 665                 670         


Thr Asp Tyr Arg Ser Leu Glu Leu Pro Leu Ser Gln Gly Phe Ala Phe 
        675                 680                 685             


Gln Leu Val Lys Leu Phe Gly Ser Pro Gly Val Pro Met Glu Ser Leu 
    690                 695                 700                 


Leu Pro Asp Asp Tyr Val Val Pro Leu Asp Trp Lys Thr Leu Lys Met 
705                 710                 715                 720 


Ile Tyr Leu Gln Trp Lys Met Ser Val Glu Lys Arg Gln Lys Lys Ile 
                725                 730                 735     


Gly 
    


<210>  9145
<211>  737
<212>  PRT
<213>  Homo Sapiens

<400>  9145

Met Ala Leu Cys Ser Ala Leu Met Thr Ile Phe Thr Ile Lys Met Gly 
1               5                   10                  15      


Thr Ala Lys Gln Ala Ile Asp Gln Gly Arg Ser Pro Val Ile Ile Asp 
            20                  25                  30          


Asn Thr Asn Ile Gln Ala Trp Glu Met Lys Pro Tyr Val Glu Val Ala 
        35                  40                  45              


Ile Gly Lys Gly Tyr Arg Val Glu Phe His Glu Pro Glu Thr Trp Trp 
    50                  55                  60                  


Lys Phe Asp Pro Glu Glu Leu Glu Lys Arg Asn Lys His Gly Val Ser 
65                  70                  75                  80  


Arg Lys Lys Ile Ala Gln Met Leu Asp Arg Tyr Glu Tyr Gln Met Ser 
                85                  90                  95      


Ile Ser Ile Val Met Asn Ser Val Glu Pro Ser His Lys Ser Thr Gln 
            100                 105                 110         


Arg Pro Pro Pro Pro Gln Gly Arg Gln Arg Glu Arg Val Leu Lys Lys 
        115                 120                 125             


Thr Gly His Arg Leu Ser Lys Thr Lys Gln Lys Arg Asn Arg Lys Arg 
    130                 135                 140                 


Asn Lys Lys Gln Asn Ser Gln Asn Arg Ile Met Glu Glu Asn Ser Leu 
145                 150                 155                 160 


Glu Phe Leu Ser Asp Leu Thr Pro Gly Asp Gln Asp Pro Ser Gln Ser 
                165                 170                 175     


Glu Glu Glu Asp Ile Glu Lys Thr Arg Arg Glu Ser Glu Tyr Pro Phe 
            180                 185                 190         


Ile Asp Gly Leu Gln Asn Glu Val Gly Asp Phe Val Thr Gly Tyr Lys 
        195                 200                 205             


Glu Lys Arg Trp Lys Asn Lys Asp Pro Lys Asp Ser Phe Gln Asn Val 
    210                 215                 220                 


Met Ser Ile Val Glu Leu Asp Asn Thr Pro Lys Asn Tyr Leu Ser Lys 
225                 230                 235                 240 


Glu Gly Asp Asn Leu Phe Val Ser Leu Leu Leu Arg Pro Asn Glu Ile 
                245                 250                 255     


Ser Val Thr Cys Pro Ile Leu Thr Gln Asn Leu Ser Cys Val Thr Thr 
            260                 265                 270         


Asp Asp Cys Ser Gly Met Lys Val Glu Lys His Ile Arg Asn Arg His 
        275                 280                 285             


Thr Ile Ala Leu Asp Thr Gln Asp Leu Ser Ala Glu Thr Ser Cys Leu 
    290                 295                 300                 


Phe Met Lys Lys Arg Glu Ile Val Asp Lys Asn Leu Ser His Glu Pro 
305                 310                 315                 320 


Ile Leu Cys His Gln His Gly Ile Arg Met Ser Asp Lys Val Leu Arg 
                325                 330                 335     


Glu Glu Gln Val Tyr Thr Thr Lys Ile Asn His Trp Ala Phe Phe Thr 
            340                 345                 350         


Thr Asn Leu Ser Asp Glu Asp Leu Gln Leu Gly Ser Asp Arg Gln Pro 
        355                 360                 365             


Tyr Phe Gly Ser Trp Pro Ala Gly Pro His Lys Phe Ile Cys Glu Gln 
    370                 375                 380                 


Arg Pro Lys Lys Asp Arg Ala Cys Lys Leu Ala Gly Pro Asp Ser Arg 
385                 390                 395                 400 


Gly Gln Trp Ile Gln Met Ile Phe Thr Ser Val Ala Ala Ser Glu Pro 
                405                 410                 415     


Gly Asn Asn Pro Glu Ile Leu Thr Asp Lys Leu Leu Ile Gly Asn Glu 
            420                 425                 430         


Asp Phe Ser Pro Pro Pro Glu Thr Met Asp Ser Phe Ile Glu Thr Asn 
        435                 440                 445             


Leu Phe Arg Ser Cys Leu Pro Gln Pro Asp Ile Pro Lys Asn Ala Leu 
    450                 455                 460                 


Glu Ser Thr Lys Asn Lys Lys Arg Arg Lys Lys Arg Ile Phe Asn Leu 
465                 470                 475                 480 


Val Pro Asn Phe Asp Leu Leu Gly Gln Ser Arg Ile Gly Val Lys Glu 
                485                 490                 495     


Arg Glu Lys Cys Asp Leu Leu Thr Lys Asn His Gly Leu Lys Ile Thr 
            500                 505                 510         


Leu Gly Glu Glu Lys Asp Arg Ile Ser Glu Arg Asn Ser Glu Glu Glu 
        515                 520                 525             


Asn Lys Gln Lys Leu Met Thr Phe Asp His His Pro Leu Trp Phe Tyr 
    530                 535                 540                 


Leu Asp Ile Ile Lys Ala Thr Pro Leu Asn Ile Asp Gly Gln Arg Tyr 
545                 550                 555                 560 


Ser His Cys Leu Ser Phe Asn Arg Leu Arg Cys Ser Ala Ser Leu Tyr 
                565                 570                 575     


Lys Asn Tyr Ile Pro Ser Phe Val Leu His Asn Leu Ser Ser Ile Trp 
            580                 585                 590         


Lys Pro Ser Phe Thr Asn Lys Lys Leu Phe Leu Thr Phe Glu Ser Gln 
        595                 600                 605             


Thr Arg Val Gly Asn Lys Leu Asn Asp Ala Gly Phe Ile Ser Pro Glu 
    610                 615                 620                 


Ile Leu His Ser His Pro Asp Thr Ser Cys Ser Leu Gly Val Thr Ser 
625                 630                 635                 640 


Asp Phe His Phe Leu Asn Glu Arg Phe Asp Arg Lys Leu Lys Arg Trp 
                645                 650                 655     


Glu Glu Pro Lys Glu Leu Pro Ala Glu Asp Ser Gln Asp Leu Thr Ser 
            660                 665                 670         


Thr Asp Tyr Arg Ser Leu Glu Leu Pro Leu Ser Gln Gly Phe Ala Phe 
        675                 680                 685             


Gln Leu Val Lys Leu Phe Gly Ser Pro Gly Val Pro Met Glu Ser Leu 
    690                 695                 700                 


Leu Pro Asp Asp Tyr Val Val Pro Leu Asp Trp Lys Thr Leu Lys Met 
705                 710                 715                 720 


Ile Tyr Leu Gln Trp Lys Met Ser Val Glu Lys Arg Gln Lys Lys Ile 
                725                 730                 735     


Gly 
    


<210>  9146
<211>  752
<212>  PRT
<213>  Homo Sapiens

<400>  9146

Met Ser Tyr Gly Glu Ile Glu Glu Phe Cys Leu Val Arg Ile Val Met 
1               5                   10                  15      


Ala Leu Cys Ser Ala Leu Met Thr Ile Phe Thr Ile Lys Met Gly Thr 
            20                  25                  30          


Ala Lys Gln Ala Ile Asp Gln Gly Arg Ser Pro Val Ile Ile Asp Asn 
        35                  40                  45              


Thr Asn Ile Gln Ala Trp Glu Met Lys Pro Tyr Val Glu Val Ala Ile 
    50                  55                  60                  


Gly Lys Gly Tyr Arg Val Glu Phe His Glu Pro Glu Thr Trp Trp Lys 
65                  70                  75                  80  


Phe Asp Pro Glu Glu Leu Glu Lys Arg Asn Lys His Gly Val Ser Arg 
                85                  90                  95      


Lys Lys Ile Ala Gln Met Leu Asp Arg Tyr Glu Tyr Gln Met Ser Ile 
            100                 105                 110         


Ser Ile Val Met Asn Ser Val Glu Pro Ser His Lys Ser Thr Gln Arg 
        115                 120                 125             


Pro Pro Pro Pro Gln Gly Arg Gln Arg Glu Arg Val Leu Lys Lys Thr 
    130                 135                 140                 


Gly His Arg Leu Ser Lys Thr Lys Gln Lys Arg Asn Arg Lys Arg Asn 
145                 150                 155                 160 


Lys Lys Gln Asn Ser Gln Asn Arg Ile Met Glu Glu Asn Ser Leu Glu 
                165                 170                 175     


Phe Leu Ser Asp Leu Thr Pro Gly Asp Gln Asp Pro Ser Gln Ser Glu 
            180                 185                 190         


Glu Glu Asp Ile Glu Lys Thr Arg Arg Glu Ser Glu Tyr Pro Phe Ile 
        195                 200                 205             


Asp Gly Leu Gln Asn Glu Val Gly Asp Phe Val Thr Gly Tyr Lys Glu 
    210                 215                 220                 


Lys Arg Trp Lys Asn Lys Asp Pro Lys Asp Ser Phe Gln Asn Val Met 
225                 230                 235                 240 


Ser Ile Val Glu Leu Asp Asn Thr Pro Lys Asn Tyr Leu Ser Lys Glu 
                245                 250                 255     


Gly Asp Asn Leu Phe Val Ser Leu Leu Leu Arg Pro Asn Glu Ile Ser 
            260                 265                 270         


Val Thr Cys Pro Ile Leu Thr Gln Asn Leu Ser Cys Val Thr Thr Asp 
        275                 280                 285             


Asp Cys Ser Gly Met Lys Val Glu Lys His Ile Arg Asn Arg His Thr 
    290                 295                 300                 


Ile Ala Leu Asp Thr Gln Asp Leu Ser Ala Glu Thr Ser Cys Leu Phe 
305                 310                 315                 320 


Met Lys Lys Arg Glu Ile Val Asp Lys Asn Leu Ser His Glu Pro Ile 
                325                 330                 335     


Leu Cys His Gln His Gly Ile Arg Met Ser Asp Lys Val Leu Arg Glu 
            340                 345                 350         


Glu Gln Val Tyr Thr Thr Lys Ile Asn His Trp Ala Phe Phe Thr Thr 
        355                 360                 365             


Asn Leu Ser Asp Glu Asp Leu Gln Leu Gly Ser Asp Arg Gln Pro Tyr 
    370                 375                 380                 


Phe Gly Ser Trp Pro Ala Gly Pro His Lys Phe Ile Cys Glu Gln Arg 
385                 390                 395                 400 


Pro Lys Lys Asp Arg Ala Cys Lys Leu Ala Gly Pro Asp Ser Arg Gly 
                405                 410                 415     


Gln Trp Ile Gln Met Ile Phe Thr Ser Val Ala Ala Ser Glu Pro Gly 
            420                 425                 430         


Asn Asn Pro Glu Ile Leu Thr Asp Lys Leu Leu Ile Gly Asn Glu Asp 
        435                 440                 445             


Phe Ser Pro Pro Pro Glu Thr Met Asp Ser Phe Ile Glu Thr Asn Leu 
    450                 455                 460                 


Phe Arg Ser Cys Leu Pro Gln Pro Asp Ile Pro Lys Asn Ala Leu Glu 
465                 470                 475                 480 


Ser Thr Lys Asn Lys Lys Arg Arg Lys Lys Arg Ile Phe Asn Leu Val 
                485                 490                 495     


Pro Asn Phe Asp Leu Leu Gly Gln Ser Arg Ile Gly Val Lys Glu Arg 
            500                 505                 510         


Glu Lys Cys Asp Leu Leu Thr Lys Asn His Gly Leu Lys Ile Thr Leu 
        515                 520                 525             


Gly Glu Glu Lys Asp Arg Ile Ser Glu Arg Asn Ser Glu Glu Glu Asn 
    530                 535                 540                 


Lys Gln Lys Leu Met Thr Phe Asp His His Pro Leu Trp Phe Tyr Leu 
545                 550                 555                 560 


Asp Ile Ile Lys Ala Thr Pro Leu Asn Ile Asp Gly Gln Arg Tyr Ser 
                565                 570                 575     


His Cys Leu Ser Phe Asn Arg Leu Arg Cys Ser Ala Ser Leu Tyr Lys 
            580                 585                 590         


Asn Tyr Ile Pro Ser Phe Val Leu His Asn Leu Ser Ser Ile Trp Lys 
        595                 600                 605             


Pro Ser Phe Thr Asn Lys Lys Leu Phe Leu Thr Phe Glu Ser Gln Thr 
    610                 615                 620                 


Arg Val Gly Asn Lys Leu Asn Asp Ala Gly Phe Ile Ser Pro Glu Ile 
625                 630                 635                 640 


Leu His Ser His Pro Asp Thr Ser Cys Ser Leu Gly Val Thr Ser Asp 
                645                 650                 655     


Phe His Phe Leu Asn Glu Arg Phe Asp Arg Lys Leu Lys Arg Trp Glu 
            660                 665                 670         


Glu Pro Lys Glu Leu Pro Ala Glu Asp Ser Gln Asp Leu Thr Ser Thr 
        675                 680                 685             


Asp Tyr Arg Ser Leu Glu Leu Pro Leu Ser Gln Gly Phe Ala Phe Gln 
    690                 695                 700                 


Leu Val Lys Leu Phe Gly Ser Pro Gly Val Pro Met Glu Ser Leu Leu 
705                 710                 715                 720 


Pro Asp Asp Tyr Val Val Pro Leu Asp Trp Lys Thr Leu Lys Met Ile 
                725                 730                 735     


Tyr Leu Gln Trp Lys Met Ser Val Glu Lys Arg Gln Lys Lys Ile Gly 
            740                 745                 750         


<210>  9147
<211>  583
<212>  PRT
<213>  Homo Sapiens

<400>  9147

Met Ser Tyr Gly Glu Ile Glu Gly Lys Phe Leu Gly Pro Arg Glu Glu 
1               5                   10                  15      


Val Thr Ser Glu Pro Arg Cys Lys Lys Leu Lys Ser Thr Thr Glu Ser 
            20                  25                  30          


Tyr Val Phe His Asn His Ser Asn Ala Asp Phe His Arg Ile Gln Glu 
        35                  40                  45              


Lys Thr Gly Asn Asp Trp Val Pro Val Thr Ile Ile Asp Val Arg Gly 
    50                  55                  60                  


His Ser Tyr Leu Gln Glu Asn Lys Ile Lys Thr Thr Asp Leu His Arg 
65                  70                  75                  80  


Pro Leu His Asp Glu Met Pro Gly Asn Arg Pro Asp Val Ile Glu Ser 
                85                  90                  95      


Ile Asp Ser Gln Val Leu Gln Glu Ala Arg Pro Pro Leu Val Ser Ala 
            100                 105                 110         


Asp Asp Glu Ile Tyr Ser Thr Ser Lys Ala Phe Ile Gly Pro Ile Tyr 
        115                 120                 125             


Lys Pro Pro Glu Lys Lys Lys Arg Asn Glu Gly Arg Asn Glu Ala His 
    130                 135                 140                 


Val Leu Asn Gly Ile Asn Asp Arg Gly Gly Gln Lys Glu Lys Gln Lys 
145                 150                 155                 160 


Phe Asn Ser Glu Lys Ser Glu Ile Asp Asn Glu Leu Phe Gln Phe Tyr 
                165                 170                 175     


Lys Glu Ile Glu Glu Leu Glu Lys Glu Lys Asp Gly Phe Glu Asn Ser 
            180                 185                 190         


Cys Lys Glu Ser Glu Pro Ser Gln Glu Gln Phe Val Pro Phe Tyr Glu 
        195                 200                 205             


Gly His Asn Asn Gly Leu Leu Lys Pro Asp Glu Glu Lys Lys Asp Leu 
    210                 215                 220                 


Ser Asn Lys Ala Met Pro Ser His Cys Asp Tyr Gln Gln Asn Leu Gly 
225                 230                 235                 240 


Asn Glu Pro Asp Lys Tyr Pro Cys Asn Gly Gln Val Ile Pro Thr Phe 
                245                 250                 255     


Cys Asp Thr Ser Phe Thr Ser Phe Arg Pro Glu Trp Gln Ser Val Tyr 
            260                 265                 270         


Pro Phe Ile Val Pro Tyr Gly Pro Pro Leu Pro Ser Leu Asn Tyr His 
        275                 280                 285             


Leu Asn Ile Gln Arg Phe Ser Gly Pro Pro Asn Pro Pro Ser Asn Ile 
    290                 295                 300                 


Phe Gln Ala Gln Asp Asp Ser Gln Ile Gln Asn Gly Tyr Tyr Val Asn 
305                 310                 315                 320 


Asn Cys His Val Asn Trp Asn Cys Met Thr Phe Asp Gln Asn Asn Glu 
                325                 330                 335     


Tyr Thr Asp Cys Ser Glu Asn Arg Ser Ser Val His Pro Ser Gly Asn 
            340                 345                 350         


Gly Cys Ser Met Gln Asp Arg Tyr Val Ser Asn Gly Phe Cys Glu Val 
        355                 360                 365             


Arg Glu Arg Cys Trp Lys Asp His Cys Met Asp Lys His Asn Gly Thr 
    370                 375                 380                 


Asp Arg Phe Val Asn Gln Gln Phe Gln Glu Glu Lys Leu Asn Lys Leu 
385                 390                 395                 400 


Gln Lys Leu Leu Ile Leu Leu Arg Gly Leu Pro Gly Ser Gly Lys Thr 
                405                 410                 415     


Thr Leu Ser Arg Ile Leu Leu Gly Gln Asn Arg Asp Gly Ile Val Phe 
            420                 425                 430         


Ser Thr Asp Asp Tyr Phe His His Gln Asp Gly Tyr Arg Tyr Asn Val 
        435                 440                 445             


Asn Gln Leu Gly Asp Ala His Asp Trp Asn Gln Asn Arg Ala Lys Gln 
    450                 455                 460                 


Ala Ile Asp Gln Gly Arg Ser Pro Val Ile Ile Asp Asn Thr Asn Ile 
465                 470                 475                 480 


Gln Ala Trp Glu Met Lys Pro Tyr Val Glu Val Ala Ile Gly Lys Gly 
                485                 490                 495     


Tyr Arg Val Glu Phe His Glu Pro Glu Thr Trp Trp Lys Phe Asp Pro 
            500                 505                 510         


Glu Glu Leu Glu Lys Arg Asn Lys His Gly Val Ser Arg Lys Lys Ile 
        515                 520                 525             


Ala Gln Met Leu Asp Arg Tyr Glu Tyr Gln Met Ser Ile Ser Ile Val 
    530                 535                 540                 


Met Asn Ser Val Glu Pro Ser His Lys Ser Thr Gln Arg Pro Pro Pro 
545                 550                 555                 560 


Pro Gln Gly Arg Gln Arg Trp Gly Gly Ser Leu Gly Ser His Asn Arg 
                565                 570                 575     


Val Cys Val Thr Asn Asn His 
            580             


<210>  9148
<211>  655
<212>  PRT
<213>  Homo Sapiens

<400>  9148

Met Ser Tyr Gly Glu Ile Glu Gly Lys Phe Leu Gly Pro Arg Glu Glu 
1               5                   10                  15      


Val Thr Ser Glu Pro Arg Cys Lys Lys Leu Lys Ser Thr Thr Glu Ser 
            20                  25                  30          


Tyr Val Phe His Asn His Ser Asn Ala Asp Phe His Arg Ile Gln Glu 
        35                  40                  45              


Lys Thr Gly Asn Asp Trp Val Pro Val Thr Ile Ile Asp Val Arg Gly 
    50                  55                  60                  


His Ser Tyr Leu Gln Glu Asn Lys Ile Lys Thr Thr Asp Leu His Arg 
65                  70                  75                  80  


Pro Leu His Asp Glu Met Pro Gly Asn Arg Pro Asp Val Ile Glu Ser 
                85                  90                  95      


Ile Asp Ser Gln Val Leu Gln Glu Ala Arg Pro Pro Leu Val Ser Ala 
            100                 105                 110         


Asp Asp Glu Ile Tyr Ser Thr Ser Lys Ala Phe Ile Gly Pro Ile Tyr 
        115                 120                 125             


Lys Pro Pro Glu Lys Lys Lys Arg Asn Glu Gly Arg Asn Glu Ala His 
    130                 135                 140                 


Val Leu Asn Gly Ile Asn Asp Arg Gly Gly Gln Lys Glu Lys Gln Lys 
145                 150                 155                 160 


Phe Asn Ser Glu Lys Ser Glu Ile Asp Asn Glu Leu Phe Gln Phe Tyr 
                165                 170                 175     


Lys Glu Ile Glu Glu Leu Glu Lys Glu Lys Asp Gly Phe Glu Asn Ser 
            180                 185                 190         


Cys Lys Glu Ser Glu Pro Ser Gln Glu Gln Phe Val Pro Phe Tyr Glu 
        195                 200                 205             


Gly His Asn Asn Gly Leu Leu Lys Pro Asp Glu Glu Lys Lys Asp Leu 
    210                 215                 220                 


Ser Asn Lys Ala Met Pro Ser His Cys Asp Tyr Gln Gln Asn Leu Gly 
225                 230                 235                 240 


Asn Glu Pro Asp Lys Tyr Pro Cys Asn Gly Gln Val Ile Pro Thr Phe 
                245                 250                 255     


Cys Asp Thr Ser Phe Thr Ser Phe Arg Pro Glu Trp Gln Ser Val Tyr 
            260                 265                 270         


Pro Phe Ile Val Pro Tyr Gly Pro Pro Leu Pro Ser Leu Asn Tyr His 
        275                 280                 285             


Leu Asn Ile Gln Arg Phe Ser Gly Pro Pro Asn Pro Pro Ser Asn Ile 
    290                 295                 300                 


Phe Gln Ala Gln Asp Asp Ser Gln Ile Gln Asn Gly Tyr Tyr Val Asn 
305                 310                 315                 320 


Asn Cys His Val Asn Trp Asn Cys Met Thr Phe Asp Gln Asn Asn Glu 
                325                 330                 335     


Tyr Thr Asp Cys Ser Glu Asn Arg Ser Ser Val His Pro Ser Gly Asn 
            340                 345                 350         


Gly Cys Ser Met Gln Asp Arg Tyr Val Ser Asn Gly Phe Cys Glu Val 
        355                 360                 365             


Arg Glu Arg Cys Trp Lys Asp His Cys Met Asp Lys His Asn Gly Thr 
    370                 375                 380                 


Asp Arg Phe Val Asn Gln Gln Phe Gln Glu Glu Lys Leu Asn Lys Leu 
385                 390                 395                 400 


Gln Lys Leu Leu Ile Leu Leu Arg Gly Leu Pro Gly Ser Gly Lys Thr 
                405                 410                 415     


Thr Leu Ser Arg Ile Leu Leu Gly Gln Asn Arg Asp Gly Ile Val Phe 
            420                 425                 430         


Ser Thr Asp Asp Tyr Phe His His Gln Asp Gly Tyr Arg Tyr Asn Val 
        435                 440                 445             


Asn Gln Leu Gly Asp Ala His Asp Trp Asn Gln Asn Arg Ala Lys Gln 
    450                 455                 460                 


Ala Ile Asp Gln Gly Arg Ser Pro Val Ile Ile Asp Asn Thr Asn Ile 
465                 470                 475                 480 


Gln Ala Trp Glu Met Lys Pro Tyr Val Glu Val Ala Ile Gly Lys Gly 
                485                 490                 495     


Tyr Arg Val Glu Phe His Glu Pro Glu Thr Trp Trp Lys Phe Asp Pro 
            500                 505                 510         


Glu Glu Leu Glu Lys Arg Asn Lys His Gly Val Ser Arg Lys Lys Ile 
        515                 520                 525             


Ala Gln Met Leu Asp Arg Tyr Glu Tyr Gln Met Ser Ile Ser Ile Val 
    530                 535                 540                 


Met Asn Ser Val Glu Pro Ser His Lys Ser Thr Gln Arg Pro Pro Pro 
545                 550                 555                 560 


Pro Gln Gly Arg Gln Arg Phe Asp Arg Lys Leu Lys Arg Trp Glu Glu 
                565                 570                 575     


Pro Lys Glu Leu Pro Ala Glu Asp Ser Gln Asp Leu Thr Ser Thr Asp 
            580                 585                 590         


Tyr Arg Ser Leu Glu Leu Pro Leu Ser Gln Gly Phe Ala Phe Gln Leu 
        595                 600                 605             


Val Lys Leu Phe Gly Ser Pro Gly Val Pro Met Glu Ser Leu Leu Pro 
    610                 615                 620                 


Asp Asp Tyr Val Val Pro Leu Asp Trp Lys Thr Leu Lys Met Ile Tyr 
625                 630                 635                 640 


Leu Gln Trp Lys Met Ser Val Glu Lys Arg Gln Lys Lys Ile Gly 
                645                 650                 655 


<210>  9149
<211>  709
<212>  PRT
<213>  Homo Sapiens

<400>  9149

Met Ser Tyr Gly Glu Ile Glu Gly Lys Phe Leu Gly Pro Arg Glu Glu 
1               5                   10                  15      


Val Thr Ser Glu Pro Arg Cys Lys Lys Leu Lys Ser Thr Thr Glu Ser 
            20                  25                  30          


Tyr Val Phe His Asn His Ser Asn Ala Asp Phe His Arg Ile Gln Glu 
        35                  40                  45              


Lys Thr Gly Asn Asp Trp Val Pro Val Thr Ile Ile Asp Val Arg Gly 
    50                  55                  60                  


His Ser Tyr Leu Gln Glu Asn Lys Ile Lys Thr Thr Asp Leu His Arg 
65                  70                  75                  80  


Pro Leu His Asp Glu Met Pro Gly Asn Arg Pro Asp Val Ile Glu Ser 
                85                  90                  95      


Ile Asp Ser Gln Val Leu Gln Glu Ala Arg Pro Pro Leu Val Ser Ala 
            100                 105                 110         


Asp Asp Glu Ile Tyr Ser Thr Ser Lys Ala Phe Ile Gly Pro Ile Tyr 
        115                 120                 125             


Lys Pro Pro Glu Lys Lys Lys Arg Asn Glu Gly Arg Asn Glu Ala His 
    130                 135                 140                 


Val Leu Asn Gly Ile Asn Asp Arg Gly Gly Gln Lys Glu Lys Gln Lys 
145                 150                 155                 160 


Phe Asn Ser Glu Lys Ser Glu Ile Asp Asn Glu Leu Phe Gln Phe Tyr 
                165                 170                 175     


Lys Glu Ile Glu Glu Leu Glu Lys Glu Lys Asp Gly Phe Glu Asn Ser 
            180                 185                 190         


Cys Lys Glu Ser Glu Pro Ser Gln Glu Gln Phe Val Pro Phe Tyr Glu 
        195                 200                 205             


Gly His Asn Asn Gly Leu Leu Lys Pro Asp Glu Glu Lys Lys Asp Leu 
    210                 215                 220                 


Ser Asn Lys Ala Met Pro Ser His Cys Asp Tyr Gln Gln Asn Leu Gly 
225                 230                 235                 240 


Asn Glu Pro Asp Lys Tyr Pro Cys Asn Gly Gln Val Ile Pro Thr Phe 
                245                 250                 255     


Cys Asp Thr Ser Phe Thr Ser Phe Arg Pro Glu Trp Gln Ser Val Tyr 
            260                 265                 270         


Pro Phe Ile Val Pro Tyr Gly Pro Pro Leu Pro Ser Leu Asn Tyr His 
        275                 280                 285             


Leu Asn Ile Gln Arg Phe Ser Gly Pro Pro Asn Pro Pro Ser Asn Ile 
    290                 295                 300                 


Phe Gln Ala Gln Asp Asp Ser Gln Ile Gln Asn Gly Tyr Tyr Val Asn 
305                 310                 315                 320 


Asn Cys His Val Asn Trp Asn Cys Met Thr Phe Asp Gln Asn Asn Glu 
                325                 330                 335     


Tyr Thr Asp Cys Ser Glu Asn Arg Ser Ser Val His Pro Ser Gly Asn 
            340                 345                 350         


Gly Cys Ser Met Gln Asp Arg Tyr Val Ser Asn Gly Phe Cys Glu Val 
        355                 360                 365             


Arg Glu Arg Cys Trp Lys Asp His Cys Met Asp Lys His Asn Gly Thr 
    370                 375                 380                 


Asp Arg Phe Val Asn Gln Gln Phe Gln Glu Glu Lys Leu Asn Lys Leu 
385                 390                 395                 400 


Gln Lys Leu Leu Ile Leu Leu Arg Gly Leu Pro Gly Ser Gly Lys Thr 
                405                 410                 415     


Thr Leu Ser Arg Ile Leu Leu Gly Gln Asn Arg Asp Gly Ile Val Phe 
            420                 425                 430         


Ser Thr Asp Asp Tyr Phe His His Gln Asp Gly Tyr Arg Tyr Asn Val 
        435                 440                 445             


Asn Gln Leu Gly Asp Ala His Asp Trp Asn Gln Asn Arg Ala Lys Gln 
    450                 455                 460                 


Ala Ile Asp Gln Gly Arg Ser Pro Val Ile Ile Asp Asn Thr Asn Ile 
465                 470                 475                 480 


Gln Ala Trp Glu Met Lys Pro Tyr Val Glu Val Ala Ile Gly Lys Gly 
                485                 490                 495     


Tyr Arg Val Glu Phe His Glu Pro Glu Thr Trp Trp Lys Phe Asp Pro 
            500                 505                 510         


Glu Glu Leu Glu Lys Arg Asn Lys His Gly Val Ser Arg Lys Lys Ile 
        515                 520                 525             


Ala Gln Met Leu Asp Arg Tyr Glu Tyr Gln Met Ser Ile Ser Ile Val 
    530                 535                 540                 


Met Asn Ser Val Glu Pro Ser His Lys Ser Thr Gln Arg Pro Pro Pro 
545                 550                 555                 560 


Pro Gln Gly Arg Gln Arg Glu Arg Val Leu Lys Lys Thr Gly His Arg 
                565                 570                 575     


Leu Ser Lys Thr Lys Gln Lys Arg Asn Arg Lys Arg Asn Lys Lys Gln 
            580                 585                 590         


Asn Ser Gln Asn Arg Ile Met Glu Glu Asn Ser Leu Glu Phe Leu Ser 
        595                 600                 605             


Asp Leu Thr Pro Gly Asp Gln Asp Pro Ser Gln Ser Glu Glu Glu Asp 
    610                 615                 620                 


Ile Glu Lys Thr Arg Arg Glu Ser Glu Tyr Pro Phe Ile Asp Gly Leu 
625                 630                 635                 640 


Gln Asn Glu Val Gly Asp Phe Val Thr Gly Tyr Lys Glu Lys Arg Trp 
                645                 650                 655     


Lys Asn Lys Asp Pro Lys Asp Ser Phe Gln Asn Val Met Ser Ile Val 
            660                 665                 670         


Glu Leu Asp Asn Thr Pro Lys Asn Tyr Leu Ser Lys Glu Gly Asp Asn 
        675                 680                 685             


Leu Phe Val Ser Leu Leu Leu Arg Pro Asn Glu Ile Ser Val Thr Cys 
    690                 695                 700                 


Pro Ile Leu Thr Gln 
705                 


<210>  9150
<211>  125
<212>  PRT
<213>  Homo Sapiens

<400>  9150

Met Ala Gly Ala Gly Pro Thr Met Leu Leu Arg Glu Glu Asn Gly Cys 
1               5                   10                  15      


Cys Ser Arg Arg Gln Ser Ser Ser Ser Ala Gly Asp Ser Asp Gly Glu 
            20                  25                  30          


Arg Glu Asp Ser Ala Ala Glu Arg Ala Arg Gln Gln Leu Glu Ala Leu 
        35                  40                  45              


Leu Asn Lys Thr Met Arg Ile Arg Met Thr Asp Gly Arg Thr Leu Val 
    50                  55                  60                  


Gly Cys Phe Leu Cys Thr Asp Arg Asp Cys Asn Val Ile Leu Gly Ser 
65                  70                  75                  80  


Ala Gln Glu Phe Leu Lys Pro Ser Asp Ser Phe Ser Ala Gly Glu Pro 
                85                  90                  95      


Arg Val Leu Gly Leu Ala Met Val Pro Gly His His Ile Val Ser Ile 
            100                 105                 110         


Glu Val Gln Arg Glu Ser Leu Thr Gly Pro Pro Tyr Leu 
        115                 120                 125 


<210>  9151
<211>  135
<212>  PRT
<213>  Homo Sapiens

<400>  9151

Met Ala Gly Ala Gly Pro Thr Met Leu Leu Arg Glu Glu Asn Gly Cys 
1               5                   10                  15      


Cys Ser Arg Arg Gln Ser Ser Ser Ser Ala Gly Asp Ser Asp Gly Glu 
            20                  25                  30          


Arg Glu Asp Ser Ala Ala Glu Arg Ala Arg Gln Gln Leu Glu Ala Leu 
        35                  40                  45              


Leu Asn Lys Thr Met Arg Ile Arg Met Thr Asp Gly Arg Thr Leu Val 
    50                  55                  60                  


Gly Cys Phe Leu Cys Thr Asp Arg Asp Cys Asn Val Ile Leu Gly Ser 
65                  70                  75                  80  


Ala Gln Glu Phe Leu Lys Pro Ser Gly Gln Cys Pro Gly Asn Ala His 
                85                  90                  95      


Pro Pro Asp Ser Phe Ser Ala Gly Glu Pro Arg Val Leu Gly Leu Ala 
            100                 105                 110         


Met Val Pro Gly His His Ile Val Ser Ile Glu Val Gln Arg Glu Ser 
        115                 120                 125             


Leu Thr Gly Pro Pro Tyr Leu 
    130                 135 


<210>  9152
<211>  173
<212>  PRT
<213>  Homo Sapiens

<400>  9152

Met Ala Val Ala Val Gly Val Arg Ala Ala Pro Val Leu Gly Leu Ala 
1               5                   10                  15      


Arg Ala Leu Val Leu Gly Leu Arg Gly Ser Gln Ala Ala Arg Trp Arg 
            20                  25                  30          


Gly Trp Gly Thr Ala Ala Pro Gly Ser Leu Trp Ala Leu Cys Glu Cys 
        35                  40                  45              


Pro Ala Gly Cys Arg Glu Leu Trp Phe Arg Gly Arg Ala Ala Trp Ala 
    50                  55                  60                  


Ala Arg Ser Glu Arg Leu Leu His Pro Ala Gln Asp Ser Asp Gly Glu 
65                  70                  75                  80  


Arg Glu Asp Ser Ala Ala Glu Arg Ala Arg Gln Gln Leu Glu Ala Leu 
                85                  90                  95      


Leu Asn Lys Thr Met Arg Ile Arg Met Thr Asp Gly Arg Thr Leu Val 
            100                 105                 110         


Gly Cys Phe Leu Cys Thr Asp Arg Asp Cys Asn Val Ile Leu Gly Ser 
        115                 120                 125             


Ala Gln Glu Phe Leu Lys Pro Ser Asp Ser Phe Ser Ala Gly Glu Pro 
    130                 135                 140                 


Arg Val Leu Gly Leu Ala Met Val Pro Gly His His Ile Val Ser Ile 
145                 150                 155                 160 


Glu Val Gln Arg Glu Ser Leu Thr Gly Pro Pro Tyr Leu 
                165                 170             


<210>  9153
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  9153

Met Asp Ser Asp Gly Glu Arg Glu Asp Ser Ala Ala Glu Arg Ala Arg 
1               5                   10                  15      


Gln Gln Leu Glu Ala Leu Leu Asn Lys Thr Met Arg Ile Arg Met Thr 
            20                  25                  30          


Asp Gly Arg Thr Leu Val Gly Cys Phe Leu Cys Thr Asp Arg Asp Cys 
        35                  40                  45              


Asn Val Ile Leu Gly Ser Ala Gln Glu Phe Leu Lys Pro Ser Asp Ser 
    50                  55                  60                  


Phe Ser Ala Gly Glu Pro Arg Val Leu Gly Leu Ala Met Val Pro Gly 
65                  70                  75                  80  


His His Ile Val Ser Ile Glu Val Gln Arg Glu Ser Leu Thr Gly Pro 
                85                  90                  95      


Pro Tyr Leu 
            


<210>  9154
<211>  73
<212>  PRT
<213>  Homo Sapiens

<400>  9154

Met Arg Ile Arg Met Thr Asp Gly Arg Thr Leu Val Gly Cys Phe Leu 
1               5                   10                  15      


Cys Thr Asp Arg Asp Cys Asn Val Ile Leu Gly Ser Ala Gln Glu Phe 
            20                  25                  30          


Leu Lys Pro Ser Asp Ser Phe Ser Ala Gly Glu Pro Arg Val Leu Gly 
        35                  40                  45              


Leu Ala Met Val Pro Gly His His Ile Val Ser Ile Glu Val Gln Arg 
    50                  55                  60                  


Glu Ser Leu Thr Gly Pro Pro Tyr Leu 
65                  70              


<210>  9155
<211>  83
<212>  PRT
<213>  Homo Sapiens

<400>  9155

Met Arg Ile Arg Met Thr Asp Gly Arg Thr Leu Val Gly Cys Phe Leu 
1               5                   10                  15      


Cys Thr Asp Arg Asp Cys Asn Val Ile Leu Gly Ser Ala Gln Glu Phe 
            20                  25                  30          


Leu Lys Pro Ser Gly Gln Cys Pro Gly Asn Ala His Pro Pro Asp Ser 
        35                  40                  45              


Phe Ser Ala Gly Glu Pro Arg Val Leu Gly Leu Ala Met Val Pro Gly 
    50                  55                  60                  


His His Ile Val Ser Ile Glu Val Gln Arg Glu Ser Leu Thr Gly Pro 
65                  70                  75                  80  


Pro Tyr Leu 
            


<210>  9156
<211>  252
<212>  PRT
<213>  Homo Sapiens

<400>  9156

Met Cys Asp Phe Met Asn Leu Ser Leu Ala Asp Cys Leu Leu Val Asn 
1               5                   10                  15      


Leu Ala Tyr Glu Ser Ser Val Phe Cys Thr Ser Ile Val Ala Gln Asp 
            20                  25                  30          


Ser Arg Gly His Ile Tyr His Gly Arg Asn Leu Asp Tyr Pro Phe Gly 
        35                  40                  45              


Asn Val Leu Arg Lys Leu Thr Val Asp Val Gln Phe Leu Lys Asn Gly 
    50                  55                  60                  


Gln Ile Ala Phe Thr Gly Thr Thr Phe Ile Gly Tyr Val Gly Leu Trp 
65                  70                  75                  80  


Thr Gly Gln Ser Pro His Lys Phe Thr Val Ser Gly Asp Glu Arg Asp 
                85                  90                  95      


Lys Gly Trp Trp Trp Glu Asn Ala Ile Ala Ala Leu Phe Arg Arg His 
            100                 105                 110         


Ile Pro Val Ser Trp Leu Ile Arg Ala Thr Leu Ser Glu Ser Glu Asn 
        115                 120                 125             


Phe Glu Ala Ala Val Gly Lys Leu Ala Lys Thr Pro Leu Ile Ala Asp 
    130                 135                 140                 


Val Tyr Tyr Ile Val Gly Gly Thr Ser Pro Arg Glu Gly Val Val Ile 
145                 150                 155                 160 


Thr Arg Asn Arg Asp Gly Pro Ala Asp Ile Trp Pro Leu Asp Pro Leu 
                165                 170                 175     


Asn Gly Ala Trp Phe Arg Val Glu Thr Asn Tyr Asp His Trp Lys Pro 
            180                 185                 190         


Ala Pro Lys Glu Asp Asp Arg Arg Thr Ser Ala Ile Lys Ala Leu Asn 
        195                 200                 205             


Ala Thr Gly Gln Ala Asn Leu Ser Leu Glu Ala Leu Phe Gln Val Thr 
    210                 215                 220                 


Cys Val Thr Val Ser Cys Ile Pro Arg Met Phe Gly Val Leu Leu Ile 
225                 230                 235                 240 


Val Asn Met Lys Asn Ser Val Lys Ser Ser Gly Arg 
                245                 250         


<210>  9157
<211>  359
<212>  PRT
<213>  Homo Sapiens

<400>  9157

Met Arg Thr Ala Asp Arg Glu Ala Arg Pro Gly Leu Pro Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ala Gly Ala Gly Leu Ser Ala Ala Ser Pro Pro Ala 
            20                  25                  30          


Ala Pro Arg Phe Asn Val Ser Leu Asp Ser Val Pro Glu Leu Arg Trp 
        35                  40                  45              


Leu Pro Val Leu Arg His Tyr Asp Leu Asp Leu Val Arg Ala Ala Met 
    50                  55                  60                  


Ala Gln Val Ile Gly Asp Arg Val Pro Lys Trp Val His Val Leu Ile 
65                  70                  75                  80  


Gly Lys Val Val Leu Glu Leu Glu Arg Phe Leu Pro Gln Pro Phe Thr 
                85                  90                  95      


Gly Glu Ile Arg Gly Met Cys Asp Phe Met Asn Leu Ser Leu Ala Asp 
            100                 105                 110         


Cys Leu Leu Val Asn Leu Ala Tyr Glu Ser Ser Val Phe Cys Thr Ser 
        115                 120                 125             


Ile Val Ala Gln Asp Ser Arg Gly His Ile Tyr His Gly Arg Asn Leu 
    130                 135                 140                 


Asp Tyr Pro Phe Gly Asn Val Leu Arg Lys Leu Thr Val Asp Val Gln 
145                 150                 155                 160 


Phe Leu Lys Asn Gly Gln Ile Ala Phe Thr Gly Thr Thr Phe Ile Gly 
                165                 170                 175     


Tyr Val Gly Leu Trp Thr Gly Gln Ser Pro His Lys Phe Thr Val Ser 
            180                 185                 190         


Gly Asp Glu Arg Asp Lys Gly Trp Trp Trp Glu Asn Ala Ile Ala Ala 
        195                 200                 205             


Leu Phe Arg Arg His Ile Pro Val Ser Trp Leu Ile Arg Ala Thr Leu 
    210                 215                 220                 


Ser Glu Ser Glu Asn Phe Glu Ala Ala Val Gly Lys Leu Ala Lys Thr 
225                 230                 235                 240 


Pro Leu Ile Ala Asp Val Tyr Tyr Ile Val Gly Gly Thr Ser Pro Arg 
                245                 250                 255     


Glu Gly Val Val Ile Thr Arg Asn Arg Asp Gly Pro Ala Asp Ile Trp 
            260                 265                 270         


Pro Leu Asp Pro Leu Asn Gly Ala Trp Phe Arg Val Glu Thr Asn Tyr 
        275                 280                 285             


Asp His Trp Lys Pro Ala Pro Lys Glu Asp Asp Arg Arg Thr Ser Ala 
    290                 295                 300                 


Ile Lys Ala Leu Asn Ala Thr Gly Gln Ala Asn Leu Ser Leu Glu Ala 
305                 310                 315                 320 


Leu Phe Gln Ile Leu Ser Val Val Pro Val Tyr Asn Asn Phe Thr Ile 
                325                 330                 335     


Tyr Thr Thr Val Met Ser Ala Gly Ser Pro Asp Lys Tyr Met Thr Arg 
            340                 345                 350         


Ile Arg Asn Pro Ser Arg Lys 
        355                 


<210>  9158
<211>  323
<212>  PRT
<213>  Homo Sapiens

<400>  9158

Met Arg Thr Ala Asp Arg Glu Ala Arg Pro Gly Leu Pro Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ala Gly Ala Gly Leu Ser Ala Ala Ser Pro Pro Ala 
            20                  25                  30          


Ala Pro Arg Phe Asn Val Ser Leu Asp Ser Val Pro Glu Leu Arg Trp 
        35                  40                  45              


Leu Pro Val Leu Arg His Tyr Asp Leu Asp Leu Val Arg Ala Ala Met 
    50                  55                  60                  


Ala Gln Val Ile Gly Asp Arg Val Pro Lys Trp Val His Val Leu Ile 
65                  70                  75                  80  


Gly Lys Val Val Leu Glu Leu Glu Arg Phe Leu Pro Gln Pro Phe Thr 
                85                  90                  95      


Gly Glu Ile Arg Gly Met Cys Asp Phe Met Asn Leu Ser Leu Ala Asp 
            100                 105                 110         


Cys Leu Leu Val Asn Leu Ala Tyr Glu Ser Ser Val Phe Cys Thr Ser 
        115                 120                 125             


Ile Val Ala Gln Asp Ser Arg Gly His Ile Tyr His Gly Arg Asn Leu 
    130                 135                 140                 


Asp Tyr Pro Phe Gly Asn Val Leu Arg Lys Leu Thr Val Asp Val Gln 
145                 150                 155                 160 


Phe Leu Lys Asn Gly Gln Ile Ala Phe Thr Gly Thr Thr Phe Ile Gly 
                165                 170                 175     


Tyr Val Gly Leu Trp Thr Gly Gln Ser Pro His Lys Phe Thr Val Ser 
            180                 185                 190         


Gly Asp Glu Arg Asp Lys Gly Trp Trp Trp Glu Asn Ala Ile Ala Ala 
        195                 200                 205             


Leu Phe Arg Arg His Ile Pro Val Ser Trp Leu Ile Arg Ala Thr Leu 
    210                 215                 220                 


Ser Glu Ser Glu Asn Phe Glu Ala Ala Val Gly Lys Leu Ala Lys Thr 
225                 230                 235                 240 


Pro Leu Ile Ala Asp Val Tyr Tyr Ile Val Gly Gly Thr Ser Pro Arg 
                245                 250                 255     


Glu Gly Val Val Ile Thr Arg Asn Arg Asp Gly Pro Ala Asp Ile Trp 
            260                 265                 270         


Pro Leu Asp Pro Leu Asn Gly Ala Trp Phe Arg Val Glu Thr Asn Tyr 
        275                 280                 285             


Asp His Trp Lys Pro Ala Pro Lys Glu Asp Asp Arg Arg Thr Ser Ala 
    290                 295                 300                 


Ile Lys Ala Leu Asn Ala Thr Gly Gln Ala Asn Leu Ser Leu Glu Ala 
305                 310                 315                 320 


Leu Phe Gln 
            


<210>  9159
<211>  167
<212>  PRT
<213>  Homo Sapiens

<400>  9159

Met Arg Thr Ala Asp Arg Glu Ala Arg Pro Gly Leu Pro Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ala Gly Ala Gly Leu Ser Ala Ala Ser Pro Pro Ala 
            20                  25                  30          


Ala Pro Arg Phe Asn Val Ser Leu Asp Ser Val Pro Glu Leu Arg Trp 
        35                  40                  45              


Leu Pro Val Leu Arg His Tyr Asp Leu Asp Leu Val Arg Ala Ala Met 
    50                  55                  60                  


Ala Gln Val Ile Gly Asp Arg Val Pro Lys Trp Val His Val Leu Ile 
65                  70                  75                  80  


Gly Lys Val Val Leu Glu Leu Glu Arg Phe Leu Pro Gln Pro Phe Thr 
                85                  90                  95      


Gly Glu Ile Arg Gly Met Cys Asp Phe Met Asn Leu Ser Leu Ala Asp 
            100                 105                 110         


Cys Leu Leu Val Asn Leu Ala Tyr Glu Ser Ser Val Phe Cys Thr Ser 
        115                 120                 125             


Ile Val Ala Gln Asp Ser Arg Gly His Ile Tyr His Gly Arg Asn Leu 
    130                 135                 140                 


Asp Tyr Pro Phe Gly Asn Val Leu Arg Lys Leu Thr Val Asp Val Gln 
145                 150                 155                 160 


Phe Leu Lys Asn Gly Gln Val 
                165         


<210>  9160
<211>  139
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9160

Xaa Asp Lys Gly Trp Trp Trp Glu Asn Ala Ile Ala Ala Leu Phe Arg 
1               5                   10                  15      


Arg His Ile Pro Val Ser Trp Leu Ile Arg Ala Thr Leu Ser Glu Ser 
            20                  25                  30          


Glu Asn Phe Glu Ala Ala Val Gly Lys Leu Ala Lys Thr Pro Leu Ile 
        35                  40                  45              


Ala Asp Val Tyr Tyr Ile Val Gly Gly Thr Ser Pro Arg Glu Gly Val 
    50                  55                  60                  


Val Ile Thr Arg Asn Arg Asp Gly Pro Ala Asp Ile Trp Pro Leu Asp 
65                  70                  75                  80  


Pro Leu Asn Gly Ala Trp Phe Arg Val Glu Thr Asn Tyr Asp His Trp 
                85                  90                  95      


Lys Pro Ala Pro Lys Glu Asp Asp Arg Arg Thr Ser Ala Ile Lys Ala 
            100                 105                 110         


Leu Asn Ala Thr Gly Gln Ala Asn Leu Ser Leu Glu Ala Leu Phe Gln 
        115                 120                 125             


Leu His Asn Leu Tyr Tyr Gly Asn Glu Arg Arg 
    130                 135                 


<210>  9161
<211>  222
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9161

Xaa Thr Ser Ile Val Ala Gln Asp Ser Arg Gly His Ile Tyr His Gly 
1               5                   10                  15      


Arg Asn Leu Asp Tyr Pro Phe Gly Asn Val Leu Arg Lys Leu Thr Val 
            20                  25                  30          


Asp Val Gln Phe Leu Lys Asn Gly Gln Ile Ala Phe Thr Gly Thr Thr 
        35                  40                  45              


Phe Ile Gly Tyr Val Gly Leu Trp Thr Gly Gln Ser Pro His Lys Phe 
    50                  55                  60                  


Thr Val Ser Gly Asp Glu Arg Asp Lys Gly Trp Trp Trp Glu Asn Ala 
65                  70                  75                  80  


Ile Ala Ala Leu Phe Arg Arg His Ile Pro Val Ser Trp Leu Ile Arg 
                85                  90                  95      


Ala Thr Leu Ser Glu Ser Glu Asn Phe Glu Ala Ala Val Gly Lys Leu 
            100                 105                 110         


Ala Lys Thr Pro Leu Ile Ala Asp Val Tyr Tyr Ile Val Gly Gly Thr 
        115                 120                 125             


Ser Pro Arg Glu Gly Val Val Ile Thr Arg Asn Arg Asp Gly Pro Ala 
    130                 135                 140                 


Asp Ile Trp Pro Leu Asp Pro Leu Asn Gly Ala Trp Phe Arg Val Glu 
145                 150                 155                 160 


Thr Asn Tyr Asp His Trp Lys Pro Ala Pro Lys Glu Asp Asp Arg Arg 
                165                 170                 175     


Thr Ser Ala Ile Lys Ala Leu Asn Ala Thr Gly Gln Ala Asn Leu Ser 
            180                 185                 190         


Leu Glu Ala Leu Phe Gln Ile Leu Ser Val Val Pro Val Tyr Asn Lys 
        195                 200                 205             


Leu Phe Pro Leu Ala Glu Phe Pro Glu Val Gly Leu Leu Ser 
    210                 215                 220         


<210>  9162
<211>  411
<212>  PRT
<213>  Homo Sapiens

<400>  9162

Met Leu Leu Lys Thr Val Leu Leu Leu Gly His Val Ala Gln Val Leu 
1               5                   10                  15      


Met Leu Asp Asn Gly Leu Leu Gln Thr Pro Pro Met Gly Trp Leu Ala 
            20                  25                  30          


Trp Glu Arg Phe Arg Cys Asn Ile Asn Cys Asp Glu Asp Pro Lys Asn 
        35                  40                  45              


Cys Ile Ser Glu Gln Leu Phe Met Glu Met Ala Asp Arg Met Ala Gln 
    50                  55                  60                  


Asp Gly Trp Arg Asp Met Gly Tyr Thr Tyr Leu Asn Ile Asp Asp Cys 
65                  70                  75                  80  


Trp Ile Gly Gly Arg Asp Ala Ser Gly Arg Leu Met Pro Asp Pro Lys 
                85                  90                  95      


Arg Phe Pro His Gly Ile Pro Phe Leu Ala Asp Tyr Val His Ser Leu 
            100                 105                 110         


Gly Leu Lys Leu Gly Ile Tyr Ala Asp Met Gly Asn Phe Thr Cys Met 
        115                 120                 125             


Gly Tyr Pro Gly Thr Thr Leu Asp Lys Val Val Gln Asp Ala Gln Thr 
    130                 135                 140                 


Phe Ala Glu Trp Lys Val Asp Met Leu Lys Leu Asp Gly Cys Phe Ser 
145                 150                 155                 160 


Thr Pro Glu Glu Arg Ala Gln Gly Tyr Pro Lys Met Ala Ala Ala Leu 
                165                 170                 175     


Asn Ala Thr Gly Arg Pro Ile Ala Phe Ser Cys Ser Trp Pro Ala Tyr 
            180                 185                 190         


Glu Gly Gly Leu Pro Pro Arg Val Asn Tyr Ser Leu Leu Ala Asp Ile 
        195                 200                 205             


Cys Asn Leu Trp Arg Asn Tyr Asp Asp Ile Gln Asp Ser Trp Trp Ser 
    210                 215                 220                 


Val Leu Ser Ile Leu Asn Trp Phe Val Glu His Gln Asp Ile Leu Gln 
225                 230                 235                 240 


Pro Val Ala Gly Pro Gly His Trp Asn Asp Pro Asp Met Leu Leu Ile 
                245                 250                 255     


Gly Asn Phe Gly Leu Ser Leu Glu Gln Ser Arg Ala Gln Met Ala Leu 
            260                 265                 270         


Trp Thr Val Leu Ala Ala Pro Leu Leu Met Ser Thr Asp Leu Arg Thr 
        275                 280                 285             


Ile Ser Ala Gln Asn Met Asp Ile Leu Gln Asn Pro Leu Met Ile Lys 
    290                 295                 300                 


Ile Asn Gln Asp Pro Leu Gly Ile Gln Gly Arg Arg Ile His Lys Glu 
305                 310                 315                 320 


Lys Ser Leu Ile Glu Val Tyr Met Arg Pro Leu Ser Asn Lys Ala Ser 
                325                 330                 335     


Ala Leu Val Phe Phe Ser Cys Arg Thr Asp Met Pro Tyr Arg Tyr His 
            340                 345                 350         


Ser Ser Leu Gly Gln Leu Asn Phe Thr Gly Ser Val Ile Tyr Glu Ala 
        355                 360                 365             


Gln Asp Val Tyr Ser Gly Asp Ile Ile Ser Gly Leu Arg Asp Glu Thr 
    370                 375                 380                 


Asn Phe Thr Val Ile Ile Asn Pro Ser Gly Val Val Met Trp Tyr Leu 
385                 390                 395                 400 


Tyr Pro Ile Lys Asn Leu Glu Met Ser Gln Gln 
                405                 410     


<210>  9163
<211>  411
<212>  PRT
<213>  Homo Sapiens

<400>  9163

Met Leu Leu Lys Thr Val Leu Leu Leu Gly His Val Ala Gln Val Leu 
1               5                   10                  15      


Met Leu Asp Asn Gly Leu Leu Gln Thr Pro Pro Met Gly Trp Leu Ala 
            20                  25                  30          


Trp Glu Arg Phe Arg Cys Asn Ile Asn Cys Asp Glu Asp Pro Lys Asn 
        35                  40                  45              


Cys Ile Ser Glu Gln Leu Phe Met Glu Met Ala Asp Arg Met Ala Gln 
    50                  55                  60                  


Asp Gly Trp Arg Asp Met Gly Tyr Thr Tyr Leu Asn Ile Asp Asp Cys 
65                  70                  75                  80  


Trp Ile Gly Gly Arg Asp Ala Ser Gly Arg Leu Met Pro Asp Pro Lys 
                85                  90                  95      


Arg Phe Pro His Gly Ile Pro Phe Leu Ala Asp Tyr Val His Ser Leu 
            100                 105                 110         


Gly Leu Lys Leu Gly Ile Tyr Ala Asp Met Gly Asn Phe Thr Cys Met 
        115                 120                 125             


Gly Tyr Pro Gly Thr Thr Leu Asp Lys Val Val Gln Asp Ala Gln Thr 
    130                 135                 140                 


Phe Ala Glu Trp Lys Val Asp Met Leu Lys Leu Asp Gly Cys Phe Ser 
145                 150                 155                 160 


Thr Pro Glu Glu Arg Ala Gln Gly Tyr Pro Lys Met Ala Ala Ala Leu 
                165                 170                 175     


Asn Ala Thr Gly Arg Pro Ile Ala Phe Ser Cys Ser Trp Pro Ala Tyr 
            180                 185                 190         


Glu Gly Gly Leu Pro Pro Arg Val Asn Tyr Ser Leu Leu Ala Asp Ile 
        195                 200                 205             


Cys Asn Leu Trp Arg Asn Tyr Asp Asp Ile Gln Asp Ser Trp Trp Ser 
    210                 215                 220                 


Val Leu Ser Ile Leu Asn Trp Phe Val Glu His Gln Asp Ile Leu Gln 
225                 230                 235                 240 


Pro Val Ala Gly Pro Gly His Trp Asn Asp Pro Asp Met Leu Leu Ile 
                245                 250                 255     


Gly Asn Phe Gly Leu Ser Leu Glu Gln Ser Arg Ala Gln Met Ala Leu 
            260                 265                 270         


Trp Thr Val Leu Ala Ala Pro Leu Leu Met Ser Thr Asp Leu Arg Thr 
        275                 280                 285             


Ile Ser Ala Gln Asn Met Asp Ile Leu Gln Asn Pro Leu Met Ile Lys 
    290                 295                 300                 


Ile Asn Gln Asp Pro Leu Gly Ile Gln Gly Arg Arg Ile His Lys Glu 
305                 310                 315                 320 


Lys Ser Leu Ile Glu Val Tyr Met Arg Pro Leu Ser Asn Lys Ala Ser 
                325                 330                 335     


Ala Leu Val Phe Phe Ser Cys Arg Thr Asp Met Pro Tyr Arg Tyr His 
            340                 345                 350         


Ser Ser Leu Gly Gln Leu Asn Phe Thr Gly Ser Val Ile Tyr Glu Ala 
        355                 360                 365             


Gln Asp Val Tyr Ser Gly Asp Ile Ile Ser Gly Leu Arg Asp Glu Thr 
    370                 375                 380                 


Asn Phe Thr Val Ile Ile Asn Pro Ser Gly Val Val Met Trp Tyr Leu 
385                 390                 395                 400 


Tyr Pro Ile Lys Asn Leu Glu Met Ser Gln Gln 
                405                 410     


<210>  9164
<211>  411
<212>  PRT
<213>  Homo Sapiens

<400>  9164

Met Leu Leu Lys Thr Val Leu Leu Leu Gly His Val Ala Gln Val Leu 
1               5                   10                  15      


Met Leu Asp Asn Gly Leu Leu Gln Thr Pro Pro Met Gly Trp Leu Ala 
            20                  25                  30          


Trp Glu Arg Phe Arg Cys Asn Ile Asn Cys Asp Glu Asp Pro Lys Asn 
        35                  40                  45              


Cys Ile Ser Glu Gln Leu Phe Met Glu Met Ala Asp Arg Met Ala Gln 
    50                  55                  60                  


Asp Gly Trp Arg Asp Met Gly Tyr Thr Tyr Leu Asn Ile Asp Asp Cys 
65                  70                  75                  80  


Trp Ile Gly Gly Arg Asp Ala Ser Gly Arg Leu Met Pro Asp Pro Lys 
                85                  90                  95      


Arg Phe Pro His Gly Ile Pro Phe Leu Ala Asp Tyr Val His Ser Leu 
            100                 105                 110         


Gly Leu Lys Leu Gly Ile Tyr Ala Asp Met Gly Asn Phe Thr Cys Met 
        115                 120                 125             


Gly Tyr Pro Gly Thr Thr Leu Asp Lys Val Val Gln Asp Ala Gln Thr 
    130                 135                 140                 


Phe Ala Glu Trp Lys Val Asp Met Leu Lys Leu Asp Gly Cys Phe Ser 
145                 150                 155                 160 


Thr Pro Glu Glu Arg Ala Gln Gly Tyr Pro Lys Met Ala Ala Ala Leu 
                165                 170                 175     


Asn Ala Thr Gly Arg Pro Ile Ala Phe Ser Cys Ser Trp Pro Ala Tyr 
            180                 185                 190         


Glu Gly Gly Leu Pro Pro Arg Val Asn Tyr Ser Leu Leu Ala Asp Ile 
        195                 200                 205             


Cys Asn Leu Trp Arg Asn Tyr Asp Asp Ile Gln Asp Ser Trp Trp Ser 
    210                 215                 220                 


Val Leu Ser Ile Leu Asn Trp Phe Val Glu His Gln Asp Ile Leu Gln 
225                 230                 235                 240 


Pro Val Ala Gly Pro Gly His Trp Asn Asp Pro Asp Met Leu Leu Ile 
                245                 250                 255     


Gly Asn Phe Gly Leu Ser Leu Glu Gln Ser Arg Ala Gln Met Ala Leu 
            260                 265                 270         


Trp Thr Val Leu Ala Ala Pro Leu Leu Met Ser Thr Asp Leu Arg Thr 
        275                 280                 285             


Ile Ser Ala Gln Asn Met Asp Ile Leu Gln Asn Pro Leu Met Ile Lys 
    290                 295                 300                 


Ile Asn Gln Asp Pro Leu Gly Ile Gln Gly Arg Arg Ile His Lys Glu 
305                 310                 315                 320 


Lys Ser Leu Ile Glu Val Tyr Met Arg Pro Leu Ser Asn Lys Ala Ser 
                325                 330                 335     


Ala Leu Val Phe Phe Ser Cys Arg Thr Asp Met Pro Tyr Arg Tyr His 
            340                 345                 350         


Ser Ser Leu Gly Gln Leu Asn Phe Thr Gly Ser Val Ile Tyr Glu Ala 
        355                 360                 365             


Gln Asp Val Tyr Ser Gly Asp Ile Ile Ser Gly Leu Arg Asp Glu Thr 
    370                 375                 380                 


Asn Phe Thr Val Ile Ile Asn Pro Ser Gly Val Val Met Trp Tyr Leu 
385                 390                 395                 400 


Tyr Pro Ile Lys Asn Leu Glu Met Ser Gln Gln 
                405                 410     


<210>  9165
<211>  743
<212>  PRT
<213>  Homo Sapiens

<400>  9165

Met Glu Ala Val Ala Val Ala Ala Ala Val Gly Val Leu Leu Leu Ala 
1               5                   10                  15      


Gly Ala Gly Gly Ala Ala Gly Asp Glu Ala Arg Glu Ala Ala Ala Val 
            20                  25                  30          


Arg Ala Leu Val Ala Arg Leu Leu Gly Pro Gly Pro Ala Ala Asp Phe 
        35                  40                  45              


Ser Val Ser Val Glu Arg Ala Leu Ala Ala Lys Pro Gly Leu Asp Thr 
    50                  55                  60                  


Tyr Ser Leu Gly Gly Gly Gly Ala Ala Arg Val Arg Val Arg Gly Ser 
65                  70                  75                  80  


Thr Gly Val Ala Ala Ala Ala Gly Leu His Arg Tyr Leu Arg Asp Phe 
                85                  90                  95      


Cys Gly Cys His Val Ala Trp Ser Gly Ser Gln Leu Arg Leu Pro Arg 
            100                 105                 110         


Pro Leu Pro Ala Val Pro Gly Glu Leu Thr Glu Ala Thr Pro Asn Arg 
        115                 120                 125             


Tyr Arg Tyr Tyr Gln Asn Val Cys Thr Gln Ser Tyr Ser Phe Val Trp 
    130                 135                 140                 


Trp Asp Trp Ala Arg Trp Glu Arg Glu Ile Asp Trp Met Ala Leu Asn 
145                 150                 155                 160 


Gly Ile Asn Leu Ala Leu Ala Trp Ser Gly Gln Glu Ala Ile Trp Gln 
                165                 170                 175     


Arg Val Tyr Leu Ala Leu Gly Leu Thr Gln Ala Glu Ile Asn Glu Phe 
            180                 185                 190         


Phe Thr Gly Pro Ala Phe Leu Ala Trp Gly Arg Met Gly Asn Leu His 
        195                 200                 205             


Thr Trp Asp Gly Pro Leu Pro Pro Ser Trp His Ile Lys Gln Leu Tyr 
    210                 215                 220                 


Leu Gln His Arg Val Leu Asp Gln Met Arg Ser Phe Gly Met Thr Pro 
225                 230                 235                 240 


Val Leu Pro Ala Phe Ala Gly His Val Pro Glu Ala Val Thr Arg Val 
                245                 250                 255     


Phe Pro Gln Val Asn Val Thr Lys Met Gly Ser Trp Gly His Phe Asn 
            260                 265                 270         


Cys Ser Tyr Ser Cys Ser Phe Leu Leu Ala Pro Glu Asp Pro Ile Phe 
        275                 280                 285             


Pro Ile Ile Gly Ser Leu Phe Leu Arg Glu Leu Ile Lys Glu Phe Gly 
    290                 295                 300                 


Thr Asp His Ile Tyr Gly Ala Asp Thr Phe Asn Glu Met Gln Pro Pro 
305                 310                 315                 320 


Ser Ser Glu Pro Ser Tyr Leu Ala Ala Ala Thr Thr Ala Val Tyr Glu 
                325                 330                 335     


Ala Met Thr Ala Val Asp Thr Glu Ala Val Trp Leu Leu Gln Gly Trp 
            340                 345                 350         


Leu Phe Gln His Gln Pro Gln Phe Trp Gly Pro Ala Gln Ile Arg Ala 
        355                 360                 365             


Val Leu Gly Ala Val Pro Arg Gly Arg Leu Leu Val Leu Asp Leu Phe 
    370                 375                 380                 


Ala Glu Ser Gln Pro Val Tyr Thr Arg Thr Ala Ser Phe Gln Gly Gln 
385                 390                 395                 400 


Pro Phe Ile Trp Cys Met Leu His Asn Phe Gly Gly Asn His Gly Leu 
                405                 410                 415     


Phe Gly Ala Leu Glu Ala Val Asn Gly Gly Pro Glu Ala Ala Arg Leu 
            420                 425                 430         


Phe Pro Asn Ser Thr Met Val Gly Thr Gly Met Ala Pro Glu Gly Ile 
        435                 440                 445             


Ser Gln Asn Glu Val Val Tyr Ser Leu Met Ala Glu Leu Gly Trp Arg 
    450                 455                 460                 


Lys Asp Pro Val Pro Asp Leu Ala Ala Trp Val Thr Ser Phe Ala Ala 
465                 470                 475                 480 


Arg Arg Tyr Gly Val Ser His Pro Asp Ala Gly Ala Ala Trp Arg Leu 
                485                 490                 495     


Leu Leu Arg Ser Val Tyr Asn Cys Ser Gly Glu Ala Cys Arg Gly His 
            500                 505                 510         


Asn Arg Ser Pro Leu Val Arg Arg Pro Ser Leu Gln Met Asn Thr Ser 
        515                 520                 525             


Ile Trp Tyr Asn Arg Ser Asp Val Phe Glu Ala Trp Arg Leu Leu Leu 
    530                 535                 540                 


Thr Ser Ala Pro Ser Leu Ala Thr Ser Pro Ala Phe Arg Tyr Asp Leu 
545                 550                 555                 560 


Leu Asp Leu Thr Arg Gln Ala Val Gln Glu Leu Val Ser Leu Tyr Tyr 
                565                 570                 575     


Glu Glu Ala Arg Ser Ala Tyr Leu Ser Lys Glu Leu Ala Ser Leu Leu 
            580                 585                 590         


Arg Ala Gly Gly Val Leu Ala Tyr Glu Leu Leu Pro Ala Leu Asp Glu 
        595                 600                 605             


Val Leu Ala Ser Asp Ser Arg Phe Leu Leu Gly Ser Trp Leu Glu Gln 
    610                 615                 620                 


Ala Arg Ala Ala Ala Val Ser Glu Ala Glu Ala Asp Phe Tyr Glu Gln 
625                 630                 635                 640 


Asn Ser Arg Tyr Gln Leu Thr Leu Trp Gly Pro Glu Gly Asn Ile Leu 
                645                 650                 655     


Asp Tyr Ala Asn Lys Gln Leu Ala Gly Leu Val Ala Asn Tyr Tyr Thr 
            660                 665                 670         


Pro Arg Trp Arg Leu Phe Leu Glu Ala Leu Val Asp Ser Val Ala Gln 
        675                 680                 685             


Gly Ile Pro Phe Gln Gln His Gln Phe Asp Lys Asn Val Phe Gln Leu 
    690                 695                 700                 


Glu Gln Ala Phe Val Leu Ser Lys Gln Arg Tyr Pro Ser Gln Pro Arg 
705                 710                 715                 720 


Gly Asp Thr Val Asp Leu Ala Lys Lys Ile Phe Leu Lys Tyr Tyr Pro 
                725                 730                 735     


Arg Trp Val Ala Gly Ser Trp 
            740             


<210>  9166
<211>  81
<212>  PRT
<213>  Homo Sapiens

<400>  9166

Met Gly Asp Leu Phe Gln Gly Arg Gly Pro Ser Arg Val Gly Cys Ala 
1               5                   10                  15      


Pro Ala His Asp Thr Ala Arg Arg Tyr Arg Tyr Tyr Gln Asn Val Cys 
            20                  25                  30          


Thr Gln Ser Tyr Ser Phe Val Trp Trp Asp Trp Ala Arg Trp Glu Arg 
        35                  40                  45              


Glu Ile Asp Trp Met Ala Leu Asn Gly Ile Asn Leu Ala Leu Ala Trp 
    50                  55                  60                  


Ser Gly Gln Glu Ala Ile Trp Gln Arg Val Tyr Leu Ala Leu Gly Leu 
65                  70                  75                  80  


Thr 
    


<210>  9167
<211>  122
<212>  PRT
<213>  Homo Sapiens

<400>  9167

Arg Gly Ala Ala Pro Leu Pro Ala Arg Leu Leu Trp Leu Pro Arg Gly 
1               5                   10                  15      


Leu Val Arg Leu Ser Ala Ala Pro Ala Ala Ala Thr Ala Ser Arg Ala 
            20                  25                  30          


Gly Gly Ala Asp Arg Gly His Ala Gln Gln Val Tyr Leu Ala Leu Gly 
        35                  40                  45              


Leu Thr Gln Ala Glu Ile Asn Glu Phe Phe Thr Gly Pro Ala Phe Leu 
    50                  55                  60                  


Ala Trp Gly Arg Met Gly Asn Leu His Thr Trp Asp Gly Pro Leu Pro 
65                  70                  75                  80  


Pro Ser Trp His Ile Lys Gln Leu Tyr Leu Gln His Arg Val Leu Asp 
                85                  90                  95      


Gln Met Arg Ser Phe Gly Met Thr Pro Val Leu Pro Ala Phe Ala Gly 
            100                 105                 110         


His Val Pro Glu Ala Val Thr Ser Gly Tyr 
        115                 120         


<210>  9168
<211>  65
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9168

Xaa Phe Gly Thr Asp His Ile Tyr Gly Ala Asp Thr Phe Asn Glu Met 
1               5                   10                  15      


Gln Pro Pro Ser Ser Glu Pro Ser Tyr Leu Ala Ala Ala Thr Thr Ala 
            20                  25                  30          


Val Tyr Glu Ala Met Thr Ala Val Leu Gly Ala Arg Pro Asp Gln Gly 
        35                  40                  45              


Cys Ala Gly Ser Cys Ala Pro Trp Pro Pro Pro Gly Ser Gly Pro Val 
    50                  55                  60                  


Cys 
65  


<210>  9169
<211>  170
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9169

Xaa Gly Arg Arg Gly Ala Ala Pro Leu Pro Ala Arg Leu Leu Trp Leu 
1               5                   10                  15      


Pro Arg Gly Leu Val Arg Leu Ser Ala Ala Pro Ala Ala Ala Thr Ala 
            20                  25                  30          


Ser Arg Ala Gly Gly Ala Asp Arg Gly His Ala Gln Gln Val Tyr Leu 
        35                  40                  45              


Ala Leu Gly Leu Thr Gln Ala Glu Ile Asn Glu Phe Phe Thr Gly Pro 
    50                  55                  60                  


Ala Phe Leu Ala Trp Gly Arg Met Gly Asn Leu His Thr Trp Asp Gly 
65                  70                  75                  80  


Pro Leu Pro Pro Ser Trp His Ile Lys Gln Leu Tyr Leu Gln His Arg 
                85                  90                  95      


Val Leu Asp Gln Met Arg Ser Phe Gly Met Thr Pro Val Leu Pro Ala 
            100                 105                 110         


Phe Ala Gly His Val Pro Glu Ala Val Thr Arg Val Phe Pro Gln Val 
        115                 120                 125             


Asn Val Thr Lys Met Gly Ser Trp Gly His Phe Asn Cys Ser Tyr Ser 
    130                 135                 140                 


Cys Ser Phe Leu Leu Ala Pro Glu Asp Pro Ile Phe Pro Ile Ile Gly 
145                 150                 155                 160 


Ser Leu Phe Leu Arg Glu Leu Ile Lys Glu 
                165                 170 


<210>  9170
<211>  534
<212>  PRT
<213>  Homo Sapiens

<400>  9170

Met Ala Thr Ala Leu Met Ala Val Val Leu Arg Ala Ala Ala Val Ala 
1               5                   10                  15      


Pro Arg Leu Arg Gly Arg Gly Gly Thr Gly Gly Ala Arg Arg Leu Ser 
            20                  25                  30          


Cys Gly Ala Arg Arg Arg Ala Ala Arg Gly Thr Ser Pro Gly Arg Arg 
        35                  40                  45              


Leu Ser Thr Ala Trp Ser Gln Pro Gln Pro Pro Pro Glu Glu Tyr Ala 
    50                  55                  60                  


Gly Ala Asp Asp Val Ser Gln Ser Pro Val Ala Glu Glu Pro Ser Trp 
65                  70                  75                  80  


Val Pro Ser Pro Arg Pro Pro Val Pro His Glu Ser Pro Glu Pro Pro 
                85                  90                  95      


Ser Gly Arg Ser Leu Val Gln Arg Asp Ile Gln Ala Phe Leu Asn Gln 
            100                 105                 110         


Cys Gly Ala Ser Pro Gly Glu Ala Arg His Trp Leu Thr Gln Phe Gln 
        115                 120                 125             


Thr Cys His His Ser Ala Asp Lys Pro Phe Ala Val Ile Glu Val Asp 
    130                 135                 140                 


Glu Glu Val Leu Lys Cys Gln Gln Gly Val Ser Ser Leu Ala Phe Ala 
145                 150                 155                 160 


Leu Ala Phe Leu Gln Arg Met Asp Met Lys Pro Leu Val Val Leu Gly 
                165                 170                 175     


Leu Pro Ala Pro Thr Ala Pro Ser Gly Cys Leu Ser Phe Trp Glu Ala 
            180                 185                 190         


Lys Ala Gln Leu Ala Lys Ser Cys Lys Val Leu Val Asp Ala Leu Arg 
        195                 200                 205             


His Asn Ala Ala Ala Ala Val Pro Phe Phe Gly Gly Gly Ser Val Leu 
    210                 215                 220                 


Arg Ala Ala Glu Pro Ala Pro His Ala Ser Tyr Gly Gly Ile Val Ser 
225                 230                 235                 240 


Val Glu Thr Asp Leu Leu Gln Trp Cys Leu Glu Ser Gly Ser Ile Pro 
                245                 250                 255     


Ile Leu Cys Pro Ile Gly Glu Thr Ala Ala Arg Arg Ser Val Leu Leu 
            260                 265                 270         


Asp Ser Leu Glu Val Thr Ala Ser Leu Ala Lys Ala Leu Arg Pro Thr 
        275                 280                 285             


Lys Ile Ile Phe Leu Asn Asn Thr Gly Gly Leu Arg Asp Ser Ser His 
    290                 295                 300                 


Lys Val Leu Ser Asn Val Asn Leu Pro Ala Asp Leu Asp Leu Val Cys 
305                 310                 315                 320 


Asn Ala Glu Trp Val Ser Thr Lys Glu Arg Gln Gln Met Arg Leu Ile 
                325                 330                 335     


Val Asp Val Leu Ser Arg Leu Pro His His Ser Ser Ala Val Ile Thr 
            340                 345                 350         


Ala Ala Ser Thr Leu Leu Thr Glu Leu Phe Ser Asn Lys Gly Ser Gly 
        355                 360                 365             


Thr Leu Phe Lys Asn Ala Glu Arg Met Leu Arg Val Arg Ser Leu Asp 
    370                 375                 380                 


Lys Leu Asp Gln Gly Arg Leu Val Asp Leu Val Asn Ala Ser Phe Gly 
385                 390                 395                 400 


Lys Lys Leu Arg Asp Asp Tyr Leu Ala Ser Leu Arg Pro Arg Leu His 
                405                 410                 415     


Ser Ile Tyr Val Ser Glu Gly Tyr Asn Ala Ala Ala Ile Leu Thr Met 
            420                 425                 430         


Glu Pro Val Leu Gly Gly Thr Pro Tyr Leu Asp Lys Phe Val Val Ser 
        435                 440                 445             


Ser Ser Arg Gln Gly Gln Gly Ser Gly Gln Met Leu Trp Glu Cys Leu 
    450                 455                 460                 


Arg Arg Asp Leu Gln Thr Leu Phe Trp Arg Ser Arg Val Thr Asn Pro 
465                 470                 475                 480 


Ile Asn Pro Trp Tyr Phe Lys His Ser Asp Gly Ser Phe Ser Asn Lys 
                485                 490                 495     


Gln Trp Ile Phe Phe Trp Phe Gly Leu Ala Asp Ile Arg Asp Ser Tyr 
            500                 505                 510         


Glu Leu Val Asn His Ala Lys Gly Leu Pro Asp Ser Phe His Lys Pro 
        515                 520                 525             


Ala Ser Asp Pro Gly Ser 
    530                 


<210>  9171
<211>  511
<212>  PRT
<213>  Homo Sapiens

<400>  9171

Ser Cys Gly Ala Arg Arg Arg Ala Ala Arg Gly Thr Ser Pro Gly Arg 
1               5                   10                  15      


Arg Leu Ser Thr Ala Trp Ser Gln Pro Gln Pro Pro Pro Glu Glu Tyr 
            20                  25                  30          


Ala Gly Ala Asp Asp Val Ser Gln Ser Pro Val Ala Glu Glu Pro Ser 
        35                  40                  45              


Trp Val Pro Ser Pro Arg Pro Pro Val Pro His Glu Ser Pro Glu Pro 
    50                  55                  60                  


Pro Ser Gly Arg Ser Leu Val Gln Arg Asp Ile Gln Ala Phe Leu Asn 
65                  70                  75                  80  


Gln Cys Gly Ala Ser Pro Gly Glu Ala Arg His Trp Leu Thr Gln Phe 
                85                  90                  95      


Gln Thr Cys His His Ser Ala Asp Lys Pro Phe Ala Val Ile Glu Val 
            100                 105                 110         


Asp Glu Glu Val Leu Lys Cys Gln Gln Gly Val Ser Ser Leu Ala Phe 
        115                 120                 125             


Ala Leu Ala Phe Leu Gln Arg Met Asp Met Lys Pro Leu Val Val Leu 
    130                 135                 140                 


Gly Leu Pro Ala Pro Thr Ala Pro Ser Gly Cys Leu Ser Phe Trp Glu 
145                 150                 155                 160 


Ala Lys Ala Gln Leu Ala Lys Ser Cys Lys Val Leu Val Asp Ala Leu 
                165                 170                 175     


Arg His Asn Ala Ala Ala Ala Val Pro Phe Phe Gly Gly Gly Ser Val 
            180                 185                 190         


Leu Arg Ala Ala Glu Pro Ala Pro His Ala Ser Tyr Gly Gly Ile Val 
        195                 200                 205             


Ser Val Glu Thr Asp Leu Leu Gln Trp Cys Leu Glu Ser Gly Ser Ile 
    210                 215                 220                 


Pro Ile Leu Cys Pro Ile Gly Glu Thr Ala Ala Arg Arg Ser Val Leu 
225                 230                 235                 240 


Leu Asp Ser Leu Glu Val Thr Ala Ser Leu Ala Lys Ala Leu Arg Pro 
                245                 250                 255     


Thr Lys Ile Ile Phe Leu Asn Asn Thr Gly Gly Leu Arg Asp Ser Ser 
            260                 265                 270         


His Lys Val Leu Ser Asn Val Asn Leu Pro Ala Asp Leu Asp Leu Val 
        275                 280                 285             


Cys Asn Ala Glu Trp Val Ser Thr Lys Glu Arg Gln Gln Met Arg Leu 
    290                 295                 300                 


Ile Val Asp Val Leu Ser Arg Leu Pro His His Ser Ser Ala Val Ile 
305                 310                 315                 320 


Thr Ala Ala Ser Thr Leu Leu Thr Glu Leu Phe Ser Asn Lys Gly Ser 
                325                 330                 335     


Gly Thr Leu Phe Lys Asn Ala Glu Arg Met Leu Arg Val Arg Ser Leu 
            340                 345                 350         


Asp Lys Leu Asp Gln Gly Arg Leu Val Asp Leu Val Asn Ala Ser Phe 
        355                 360                 365             


Gly Lys Lys Leu Arg Asp Asp Tyr Leu Ala Ser Leu Arg Pro Arg Leu 
    370                 375                 380                 


His Ser Ile Tyr Val Ser Glu Gly Leu Pro Leu Ser Arg Cys Ala Arg 
385                 390                 395                 400 


Tyr Asn Ala Ala Ala Ile Leu Thr Met Glu Pro Val Leu Gly Gly Thr 
                405                 410                 415     


Pro Tyr Leu Asp Lys Phe Val Val Ser Ser Ser Arg Gln Gly Gln Gly 
            420                 425                 430         


Ser Gly Gln Met Leu Trp Glu Cys Leu Arg Arg Asp Leu Gln Thr Leu 
        435                 440                 445             


Phe Trp Arg Ser Arg Val Thr Asn Pro Ile Asn Pro Trp Tyr Phe Lys 
    450                 455                 460                 


His Ser Asp Gly Ser Phe Ser Asn Lys Gln Trp Ile Phe Phe Trp Phe 
465                 470                 475                 480 


Gly Leu Ala Asp Ile Arg Asp Ser Tyr Glu Leu Val Asn His Ala Lys 
                485                 490                 495     


Gly Leu Pro Asp Ser Phe His Lys Pro Ala Ser Asp Pro Gly Ser 
            500                 505                 510     


<210>  9172
<211>  104
<212>  PRT
<213>  Homo Sapiens

<400>  9172

Met Ser Pro Pro Pro Leu Leu Gln Pro Leu Leu Leu Leu Leu Pro Leu 
1               5                   10                  15      


Leu Asn Val Glu Pro Ser Gly Ala Thr Leu Ile Arg Ile Pro Leu His 
            20                  25                  30          


Arg Val Gln Pro Gly Arg Arg Ile Leu Asn Leu Leu Arg Gly Trp Arg 
        35                  40                  45              


Glu Pro Ala Glu Leu Pro Lys Leu Gly Ala Pro Ser Pro Gly Asp Lys 
    50                  55                  60                  


Pro Ile Phe Val Pro Leu Ser Asn Tyr Arg Asp Gly Tyr Thr Thr Asp 
65                  70                  75                  80  


Leu Ile Pro Lys Pro Leu Ala Pro Ser Arg Pro Met Gly Pro Ser Leu 
                85                  90                  95      


Pro Phe Asn Met Glu Leu Gly Gly 
            100                 


<210>  9173
<211>  268
<212>  PRT
<213>  Homo Sapiens

<400>  9173

Met Ser Pro Pro Pro Leu Leu Gln Pro Leu Leu Leu Leu Leu Pro Leu 
1               5                   10                  15      


Leu Asn Val Glu Pro Ser Gly Ala Thr Leu Ile Arg Ile Pro Leu His 
            20                  25                  30          


Arg Val Gln Pro Gly Arg Arg Ile Leu Asn Leu Leu Arg Gly Trp Arg 
        35                  40                  45              


Glu Pro Ala Glu Leu Pro Lys Leu Gly Ala Pro Ser Pro Gly Asp Lys 
    50                  55                  60                  


Pro Ile Phe Val Pro Leu Ser Asn Tyr Arg Asp Val Gln Tyr Phe Gly 
65                  70                  75                  80  


Glu Ile Gly Leu Gly Thr Pro Pro Gln Asn Phe Thr Val Ala Phe Asp 
                85                  90                  95      


Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Arg Arg Cys His Phe Phe 
            100                 105                 110         


Ser Val Pro Cys Ser Ser Ser Ser Phe Gln Ala Asn Gly Thr Lys Phe 
        115                 120                 125             


Ala Ile Gln Tyr Gly Thr Gly Arg Val Asp Gly Ile Leu Ser Glu Asp 
    130                 135                 140                 


Lys Leu Thr Ile Gly Gly Ile Lys Gly Ala Ser Val Ile Phe Gly Glu 
145                 150                 155                 160 


Ala Leu Trp Glu Pro Ser Leu Val Phe Ala Phe Ala His Phe Asp Gly 
                165                 170                 175     


Ile Leu Gly Leu Gly Phe Pro Ile Leu Ser Val Glu Gly Val Arg Pro 
            180                 185                 190         


Pro Met Asp Val Leu Val Glu Gln Gly Leu Leu Asp Lys Pro Val Phe 
        195                 200                 205             


Ser Phe Tyr Leu Asn Arg Asp Pro Glu Glu Pro Asp Gly Gly Glu Leu 
    210                 215                 220                 


Val Leu Gly Gly Ser Asp Pro Ala His Tyr Ile Pro Pro Leu Thr Phe 
225                 230                 235                 240 


Val Pro Val Thr Val Pro Ala Tyr Trp Gln Ile His Met Glu Arg Val 
                245                 250                 255     


Lys Val Gly Pro Gly Leu Thr Leu Cys Ala Lys Gly 
            260                 265             


<210>  9174
<211>  420
<212>  PRT
<213>  Homo Sapiens

<400>  9174

Met Ser Pro Pro Pro Leu Leu Gln Pro Leu Leu Leu Leu Leu Pro Leu 
1               5                   10                  15      


Leu Asn Val Glu Pro Ser Gly Ala Thr Leu Ile Arg Ile Pro Leu His 
            20                  25                  30          


Arg Val Gln Pro Gly Arg Arg Ile Leu Asn Leu Leu Arg Gly Trp Arg 
        35                  40                  45              


Glu Pro Ala Glu Leu Pro Lys Leu Gly Ala Pro Ser Pro Gly Asp Lys 
    50                  55                  60                  


Pro Ile Phe Val Pro Leu Ser Asn Tyr Arg Asp Val Gln Tyr Phe Gly 
65                  70                  75                  80  


Glu Ile Gly Leu Gly Thr Pro Pro Gln Asn Phe Thr Val Ala Phe Asp 
                85                  90                  95      


Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Arg Arg Cys His Phe Phe 
            100                 105                 110         


Ser Val Pro Cys Trp Leu His His Arg Phe Asp Pro Lys Ala Ser Ser 
        115                 120                 125             


Ser Phe Gln Ala Asn Gly Thr Lys Phe Ala Ile Gln Tyr Gly Thr Gly 
    130                 135                 140                 


Arg Val Asp Gly Ile Leu Ser Glu Asp Lys Leu Thr Ile Gly Gly Ile 
145                 150                 155                 160 


Lys Gly Ala Ser Val Ile Phe Gly Glu Ala Leu Trp Glu Pro Ser Leu 
                165                 170                 175     


Val Phe Ala Phe Ala His Phe Asp Gly Ile Leu Gly Leu Gly Phe Pro 
            180                 185                 190         


Ile Leu Ser Val Glu Gly Val Arg Pro Pro Met Asp Val Leu Val Glu 
        195                 200                 205             


Gln Gly Leu Leu Asp Lys Pro Val Phe Ser Phe Tyr Leu Asn Arg Asp 
    210                 215                 220                 


Pro Glu Glu Pro Asp Gly Gly Glu Leu Val Leu Gly Gly Ser Asp Pro 
225                 230                 235                 240 


Ala His Tyr Ile Pro Pro Leu Thr Phe Val Pro Val Thr Val Pro Ala 
                245                 250                 255     


Tyr Trp Gln Ile His Met Glu Arg Val Lys Val Gly Pro Gly Leu Thr 
            260                 265                 270         


Leu Cys Ala Lys Gly Cys Ala Ala Ile Leu Asp Thr Gly Thr Ser Leu 
        275                 280                 285             


Ile Thr Gly Pro Thr Glu Glu Ile Arg Ala Leu His Ala Ala Ile Gly 
    290                 295                 300                 


Gly Ile Pro Leu Leu Ala Gly Glu Tyr Ile Ile Leu Cys Ser Glu Ile 
305                 310                 315                 320 


Pro Lys Leu Pro Ala Val Ser Phe Leu Leu Gly Gly Val Trp Phe Asn 
                325                 330                 335     


Leu Thr Ala His Asp Tyr Val Ile Gln Thr Thr Arg Asn Gly Val Arg 
            340                 345                 350         


Leu Cys Leu Ser Gly Phe Gln Ala Leu Asp Val Pro Pro Pro Ala Gly 
        355                 360                 365             


Pro Phe Trp Ile Leu Gly Asp Val Phe Leu Gly Thr Tyr Val Ala Val 
    370                 375                 380                 


Phe Asp Arg Gly Asp Met Lys Ser Ser Ala Arg Val Gly Leu Ala Arg 
385                 390                 395                 400 


Ala Arg Thr Arg Gly Ala Asp Leu Gly Trp Gly Glu Thr Ala Gln Ala 
                405                 410                 415     


Gln Phe Pro Gly 
            420 


<210>  9175
<211>  237
<212>  PRT
<213>  Homo Sapiens

<400>  9175

Met Leu Pro Asp Gly Pro Gly Ser Ser Leu Trp Gly Asn Pro Gly Leu 
1               5                   10                  15      


Gln Thr Ser Asp Ser Pro Asn Ala Val His Glu Val Glu Lys Trp Leu 
            20                  25                  30          


Pro Arg Leu His Ala Leu Val Val Gly Pro Gly Leu Gly Arg Asp Asp 
        35                  40                  45              


Ala Leu Leu Arg Asn Val Gln Gly Ile Leu Glu Val Ser Lys Ala Arg 
    50                  55                  60                  


Asp Ile Pro Val Val Ile Asp Ala Asp Gly Leu Trp Leu Val Ala Gln 
65                  70                  75                  80  


Gln Pro Ala Leu Ile His Gly Tyr Arg Lys Ala Val Leu Thr Pro Asn 
                85                  90                  95      


His Val Glu Phe Ser Arg Leu Tyr Asp Ala Val Leu Arg Gly Pro Met 
            100                 105                 110         


Asp Ser Asp Asp Ser His Gly Ser Val Leu Arg Leu Ser Gln Ala Leu 
        115                 120                 125             


Gly Asn Val Thr Val Val Gln Lys Gly Glu Arg Asp Ile Leu Ser Asn 
    130                 135                 140                 


Gly Gln Gln Val Leu Val Cys Ser Gln Glu Gly Ser Ser Arg Arg Cys 
145                 150                 155                 160 


Gly Gly Gln Gly Asp Leu Leu Ser Gly Ser Leu Gly Val Leu Val His 
                165                 170                 175     


Trp Ala Leu Leu Ala Gly Pro Gln Lys Thr Asn Gly Ser Ser Pro Leu 
            180                 185                 190         


Leu Val Ala Ala Phe Gly Ala Cys Ser Leu Thr Arg Gln Cys Asn His 
        195                 200                 205             


Gln Ala Phe Gln Lys His Gly Arg Ser Thr Thr Thr Ser Asp Met Ile 
    210                 215                 220                 


Ala Glu Val Gly Ala Ala Phe Ser Lys Leu Phe Glu Thr 
225                 230                 235         


<210>  9176
<211>  390
<212>  PRT
<213>  Homo Sapiens

<400>  9176

Met Val Thr Arg Ala Gly Ala Gly Thr Ala Val Ala Gly Ala Val Val 
1               5                   10                  15      


Val Ala Leu Leu Ser Ala Ala Leu Ala Leu Tyr Gly Pro Pro Leu Asp 
            20                  25                  30          


Ala Val Leu Glu Arg Ala Phe Ser Leu Arg Lys Ala His Ser Ile Lys 
        35                  40                  45              


Asp Met Glu Asn Thr Leu Gln Leu Val Arg Asn Ile Ile Pro Pro Leu 
    50                  55                  60                  


Ser Ser Thr Lys His Lys Gly Gln Asp Gly Arg Ile Gly Val Val Gly 
65                  70                  75                  80  


Gly Cys Gln Glu Tyr Thr Gly Ala Pro Tyr Phe Ala Ala Ile Ser Ala 
                85                  90                  95      


Leu Lys Val Gly Ala Asp Leu Ser His Val Phe Cys Ala Ser Ala Ala 
            100                 105                 110         


Ala Pro Val Ile Lys Ala Tyr Ser Pro Glu Leu Ile Val His Pro Val 
        115                 120                 125             


Leu Asp Ser Pro Asn Ala Val His Glu Val Glu Lys Trp Leu Pro Arg 
    130                 135                 140                 


Leu His Ala Leu Val Val Gly Pro Gly Leu Gly Arg Asp Asp Ala Leu 
145                 150                 155                 160 


Leu Arg Asn Val Gln Gly Ile Leu Glu Val Ser Lys Ala Arg Asp Ile 
                165                 170                 175     


Pro Val Val Ile Asp Ala Asp Gly Leu Trp Leu Val Ala Gln Gln Pro 
            180                 185                 190         


Ala Leu Ile His Gly Tyr Arg Lys Ala Val Leu Thr Pro Asn His Val 
        195                 200                 205             


Glu Phe Ser Arg Leu Tyr Asp Ala Val Leu Arg Gly Pro Met Asp Ser 
    210                 215                 220                 


Asp Asp Ser His Gly Ser Val Leu Arg Leu Ser Gln Ala Leu Gly Asn 
225                 230                 235                 240 


Val Thr Val Val Gln Lys Gly Glu Arg Asp Ile Leu Ser Asn Gly Gln 
                245                 250                 255     


Gln Val Leu Val Cys Ser Gln Glu Gly Ser Ser Arg Arg Cys Gly Gly 
            260                 265                 270         


Gln Gly Asp Leu Leu Ser Gly Ser Leu Gly Val Leu Val His Trp Ala 
        275                 280                 285             


Leu Leu Ala Gly Pro Gln Lys Thr Asn Gly Gly Ile Ser Asp Leu Lys 
    290                 295                 300                 


Leu Thr Ile Trp Gly Pro Glu Ile Glu Thr Gly Val Lys Thr Arg Ala 
305                 310                 315                 320 


Gln Gly Ser Cys Gly Pro Arg Thr Thr Thr Pro Thr Ser Pro His Leu 
                325                 330                 335     


Leu Leu Ser Pro Ser Pro Gln Val Gln Pro Ser Pro Gly Gly Arg Val 
            340                 345                 350         


Trp Arg Leu Leu Ser His Gln Ala Val Gln Pro Pro Ser Leu Pro Glu 
        355                 360                 365             


Ala Arg Ser Leu His His His Leu Arg His Asp Arg Arg Gly Gly Gly 
    370                 375                 380                 


Arg Leu Gln Gln Ala Leu 
385                 390 


<210>  9177
<211>  260
<212>  PRT
<213>  Homo Sapiens

<400>  9177

Met Ser Arg Leu Arg Ala Leu Leu Gly Leu Gly Leu Leu Val Ala Gly 
1               5                   10                  15      


Ser Arg Val Pro Arg Ile Lys Ser Gln Thr Ile Ala Cys Arg Ser Gly 
            20                  25                  30          


Pro Thr Trp Trp Gly Pro Gln Arg Leu Asn Ser Gly Gly Arg Trp Asp 
        35                  40                  45              


Ser Glu Val Met Ala Ser Thr Val Val Lys Tyr Leu Ser Gln Glu Glu 
    50                  55                  60                  


Ala Gln Ala Val Asp Gln Glu Leu Phe Asn Glu Tyr Gln Phe Ser Val 
65                  70                  75                  80  


Asp Gln Leu Met Glu Leu Ala Gly Leu Ser Cys Ala Thr Ala Ile Ala 
                85                  90                  95      


Lys Ala Tyr Pro Pro Thr Ser Met Ser Arg Ser Pro Pro Thr Val Leu 
            100                 105                 110         


Val Ile Cys Gly Pro Gly Asn Asn Gly Gly Asp Gly Leu Val Cys Ala 
        115                 120                 125             


Arg His Leu Lys Leu Phe Gly Tyr Glu Pro Thr Ile Tyr Tyr Pro Lys 
    130                 135                 140                 


Arg Pro Asn Lys Pro Leu Phe Thr Ala Leu Val Thr Gln Cys Gln Lys 
145                 150                 155                 160 


Met Asp Ile Pro Phe Leu Gly Glu Met Pro Ala Glu Leu Gln Gly Arg 
                165                 170                 175     


Cys Ser Gly Thr Val Pro Gln His Pro Glu Cys Pro Glu Gly Thr His 
            180                 185                 190         


Cys Ala His Cys Gln His Arg His Ser Leu Arg Met Gly Arg Gly Glu 
        195                 200                 205             


Gly Lys Cys Trp Arg Asp Pro Ala Arg Leu Ala His Ile Pro His Ser 
    210                 215                 220                 


Pro Gln Lys Ile Cys Asn Pro Val Tyr Arg Ser Leu Pro Leu Pro Gly 
225                 230                 235                 240 


Gly Ser Phe Cys Ala Thr Cys Ser Gly Glu Glu Val Pro Ala Glu Pro 
                245                 250                 255     


Ala Thr Leu Pro 
            260 


<210>  9178
<211>  245
<212>  PRT
<213>  Homo Sapiens

<400>  9178

Met Ser Arg Leu Arg Ala Leu Leu Gly Leu Gly Leu Leu Val Ala Gly 
1               5                   10                  15      


Ser Arg Val Pro Arg Ile Lys Ser Gln Thr Ile Ala Cys Arg Ser Gly 
            20                  25                  30          


Pro Thr Trp Trp Gly Pro Gln Arg Leu Asn Ser Gly Gly Arg Trp Asp 
        35                  40                  45              


Ser Glu Val Met Ala Ser Thr Val Val Lys Tyr Leu Ser Gln Glu Glu 
    50                  55                  60                  


Ala Gln Ala Val Asp Gln Glu Leu Phe Asn Glu Tyr Gln Phe Ser Val 
65                  70                  75                  80  


Asp Gln Leu Met Glu Leu Ala Gly Leu Ser Cys Ala Thr Ala Ile Ala 
                85                  90                  95      


Lys Ala Tyr Pro Pro Thr Ser Met Ser Arg Ser Pro Pro Thr Val Leu 
            100                 105                 110         


Val Ile Cys Gly Pro Gly Asn Asn Gly Gly Asp Gly Leu Val Cys Ala 
        115                 120                 125             


Arg His Leu Lys Leu Phe Gly Tyr Glu Pro Thr Ile Tyr Tyr Pro Lys 
    130                 135                 140                 


Arg Pro Asn Lys Pro Leu Phe Thr Ala Leu Val Thr Gln Cys Gln Lys 
145                 150                 155                 160 


Met Asp Ile Pro Phe Leu Gly Glu Met Pro Ala Glu Pro Met Thr Ile 
                165                 170                 175     


Asp Glu Leu Tyr Glu Leu Val Val Asp Ala Ile Phe Gly Phe Ser Phe 
            180                 185                 190         


Lys Gly Asp Val Arg Glu Pro Phe His Ser Ile Leu Ser Val Leu Lys 
        195                 200                 205             


Gly Leu Thr Val Pro Ile Ala Ser Ile Asp Ile Pro Ser Gly Ala Gly 
    210                 215                 220                 


Ile Gln Lys Val Gly Trp Gly Arg Leu Gly Pro Tyr Pro Pro Asp Ser 
225                 230                 235                 240 


Cys Pro His Gln Val 
                245 


<210>  9179
<211>  288
<212>  PRT
<213>  Homo Sapiens

<400>  9179

Met Ser Arg Leu Arg Ala Leu Leu Gly Leu Gly Leu Leu Val Ala Gly 
1               5                   10                  15      


Ser Arg Val Pro Arg Ile Lys Ser Gln Thr Ile Ala Cys Arg Ser Gly 
            20                  25                  30          


Pro Thr Trp Trp Gly Pro Gln Arg Leu Asn Ser Gly Gly Arg Trp Asp 
        35                  40                  45              


Ser Glu Val Met Ala Ser Thr Val Val Lys Tyr Leu Ser Gln Glu Glu 
    50                  55                  60                  


Ala Gln Ala Val Asp Gln Glu Leu Phe Asn Glu Tyr Gln Phe Ser Val 
65                  70                  75                  80  


Asp Gln Leu Met Glu Leu Ala Gly Leu Ser Cys Ala Thr Ala Ile Ala 
                85                  90                  95      


Lys Ala Tyr Pro Pro Thr Ser Met Ser Arg Ser Pro Pro Thr Val Leu 
            100                 105                 110         


Val Ile Cys Gly Pro Gly Asn Asn Gly Gly Asp Gly Leu Val Cys Ala 
        115                 120                 125             


Arg His Leu Lys Leu Phe Gly Tyr Glu Pro Thr Ile Tyr Tyr Pro Lys 
    130                 135                 140                 


Arg Pro Asn Lys Pro Leu Phe Thr Ala Leu Val Thr Gln Cys Gln Lys 
145                 150                 155                 160 


Met Asp Ile Pro Phe Leu Gly Glu Met Pro Ala Glu Pro Met Thr Ile 
                165                 170                 175     


Asp Glu Leu Tyr Glu Leu Val Val Asp Ala Ile Phe Gly Phe Ser Phe 
            180                 185                 190         


Lys Gly Asp Val Arg Glu Pro Phe His Ser Ile Leu Ser Val Leu Lys 
        195                 200                 205             


Gly Leu Thr Val Pro Ile Ala Ser Ile Asp Ile Pro Ser Gly Trp Asp 
    210                 215                 220                 


Val Glu Lys Gly Asn Ala Gly Gly Ile Gln Pro Asp Leu Leu Ile Ser 
225                 230                 235                 240 


Leu Thr Ala Pro Lys Lys Ser Ala Thr Gln Phe Thr Gly Arg Tyr His 
                245                 250                 255     


Tyr Leu Gly Gly Arg Phe Val Pro Pro Ala Leu Glu Lys Lys Tyr Gln 
            260                 265                 270         


Leu Asn Leu Pro Pro Tyr Pro Asp Thr Glu Cys Val Tyr Arg Leu Gln 
        275                 280                 285             


<210>  9180
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  9180

Met Cys Ser Leu Ala Leu Gln Gln Leu Ile Ser Met Asp Leu Phe Trp 
1               5                   10                  15      


Arg Leu Phe Phe Val Cys Gly Gln Glu Gly Leu Arg Ala Leu Glu Ala 
            20                  25                  30          


Thr Gly Met Met Leu Arg Val Leu Val Gly Ala Val Leu Pro Ala Met 
        35                  40                  45              


Leu Leu Ala Ala Pro Pro Pro Ile Asn Lys Leu Ala Leu Phe Pro Asp 
    50                  55                  60                  


Lys Ser Ala Trp Cys Glu Ala Lys Asn Ile Thr Gln Ile Val Gly His 
65                  70                  75                  80  


Ser Gly Cys Glu Ala Lys Ser Ile Gln Asn Arg Ala Cys Leu Gly Gln 
                85                  90                  95      


Cys Phe Ser Tyr Ser Val Pro Asn Thr Phe Pro Gln Ser Thr Glu Ser 
            100                 105                 110         


Leu Val His Cys Asp Ser Cys Met Pro Ala Gln Ser Met Trp Glu Ile 
        115                 120                 125             


<210>  9181
<211>  215
<212>  PRT
<213>  Homo Sapiens

<400>  9181

Met Cys Ser Leu Ala Leu Gln Gln Leu Ile Ser Met Asp Leu Phe Trp 
1               5                   10                  15      


Arg Leu Phe Phe Val Cys Gly Gln Glu Gly Leu Arg Ala Leu Glu Ala 
            20                  25                  30          


Thr Gly Met Met Leu Arg Val Leu Val Gly Ala Val Leu Pro Ala Met 
        35                  40                  45              


Leu Leu Ala Ala Pro Pro Pro Ile Asn Lys Leu Ala Leu Phe Pro Asp 
    50                  55                  60                  


Lys Ser Ala Trp Cys Glu Ala Lys Asn Ile Thr Gln Ile Val Gly His 
65                  70                  75                  80  


Ser Gly Cys Glu Ala Lys Ser Ile Gln Asn Arg Ala Cys Leu Gly Gln 
                85                  90                  95      


Cys Phe Ser Tyr Ser Val Pro Asn Thr Phe Pro Gln Ser Thr Glu Ser 
            100                 105                 110         


Leu Val His Cys Asp Ser Cys Met Pro Ala Gln Ser Met Trp Glu Ile 
        115                 120                 125             


Val Thr Leu Glu Cys Pro Gly His Glu Glu Val Pro Arg Val Asp Lys 
    130                 135                 140                 


Leu Val Glu Lys Ile Leu His Cys Ser Cys Gln Ala Cys Gly Lys Glu 
145                 150                 155                 160 


Pro Ser His Glu Gly Leu Ser Val Tyr Val Gln Gly Glu Asp Gly Pro 
                165                 170                 175     


Gly Ser Gln Pro Gly Thr His Pro His Pro His Pro His Pro His Pro 
            180                 185                 190         


Gly Gly Gln Thr Pro Glu Pro Glu Asp Pro Pro Gly Ala Pro His Thr 
        195                 200                 205             


Glu Glu Glu Gly Ala Glu Asp 
    210                 215 


<210>  9182
<211>  163
<212>  PRT
<213>  Homo Sapiens

<400>  9182

Met Leu Arg Val Leu Val Gly Ala Val Leu Pro Ala Met Leu Leu Ala 
1               5                   10                  15      


Ala Pro Pro Pro Ile Asn Lys Leu Ala Leu Phe Pro Asp Lys Ser Ala 
            20                  25                  30          


Trp Cys Glu Ala Lys Asn Ile Thr Gln Ile Val Gly His Ser Gly Cys 
        35                  40                  45              


Glu Ala Lys Ser Ile Gln Asn Arg Ala Cys Leu Gly Gln Cys Phe Ser 
    50                  55                  60                  


Tyr Ser Val Pro Asn Thr Phe Pro Gln Ser Thr Glu Ser Leu Val His 
65                  70                  75                  80  


Cys Asp Ser Cys Met Pro Ala Gln Ser Met Trp Glu Ile Val Thr Leu 
                85                  90                  95      


Glu Cys Pro Gly His Glu Glu Val Pro Arg Val Asp Lys Leu Val Glu 
            100                 105                 110         


Lys Ile Leu His Cys Ser Cys Gln Ala Cys Gly Lys Glu Pro Ser His 
        115                 120                 125             


Glu Gly Leu Ser Val Tyr Val Gln Gly Glu Asp Gly Pro Gly Ser Gln 
    130                 135                 140                 


Pro Gly Thr His Pro His Pro His Pro His Pro His Pro Gly Gly Gln 
145                 150                 155                 160 


Thr Pro Glu 
            


<210>  9183
<211>  109
<212>  PRT
<213>  Homo Sapiens

<400>  9183

Met Met Leu Arg Val Leu Val Gly Ala Val Leu Pro Ala Met Leu Leu 
1               5                   10                  15      


Ala Ala Pro Pro Pro Ile Asn Lys Leu Ala Leu Phe Pro Asp Lys Ser 
            20                  25                  30          


Ala Trp Cys Glu Ala Lys Asn Ile Thr Gln Ile Val Gly His Ser Gly 
        35                  40                  45              


Cys Glu Ala Lys Ser Ile Gln Asn Arg Ala Cys Leu Gly Gln Cys Phe 
    50                  55                  60                  


Ser Tyr Ser Val Pro Asn Thr Phe Pro Gln Ser Thr Glu Ser Leu Val 
65                  70                  75                  80  


His Cys Asp Ser Cys Met Pro Ala Gln Ser Met Trp Glu Ile Val Thr 
                85                  90                  95      


Leu Glu Cys Pro Gly His Glu Glu Val Pro Arg Val Asp 
            100                 105                 


<210>  9184
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  9184

Met Met Leu Arg Val Leu Val Gly Ala Val Leu Pro Ala Met Leu Leu 
1               5                   10                  15      


Ala Ala Pro Pro Pro Ile Asn Lys Leu Ala Leu Phe Pro Asp Lys Ser 
            20                  25                  30          


Ala Trp Cys Glu Ala Lys Asn Ile Thr Gln Ile Val Gly His Ser Gly 
        35                  40                  45              


Cys Glu Ala Lys Ser Ile Gln Asn Arg Ala Cys Leu Gly Gln Cys Phe 
    50                  55                  60                  


Ser Tyr Ser Val Pro Asn Thr Phe Pro Gln Ser Thr Glu Ser Leu Val 
65                  70                  75                  80  


His Cys Asp Ser Cys Met Pro Ala Gln Ser Met Trp Glu Ile Val Thr 
                85                  90                  95      


Leu Glu Cys Pro Gly His Glu Glu Val Pro Arg Val Asp Lys Leu Val 
            100                 105                 110         


Glu Lys Ile Leu 
        115     


<210>  9185
<211>  117
<212>  PRT
<213>  Homo Sapiens

<400>  9185

Met Met Leu Arg Val Leu Val Gly Ala Val Leu Pro Ala Met Leu Leu 
1               5                   10                  15      


Ala Ala Pro Pro Pro Ile Asn Lys Leu Ala Leu Phe Pro Asp Lys Ser 
            20                  25                  30          


Ala Trp Cys Glu Ala Lys Asn Ile Thr Gln Ile Val Gly His Ser Gly 
        35                  40                  45              


Cys Glu Ala Lys Ser Ile Gln Asn Arg Ala Cys Leu Gly Gln Cys Phe 
    50                  55                  60                  


Ser Tyr Ser Val Pro Asn Thr Phe Pro Gln Ser Thr Glu Ser Leu Val 
65                  70                  75                  80  


His Cys Asp Ser Cys Met Pro Ala Gln Ser Met Trp Glu Ile Val Thr 
                85                  90                  95      


Leu Glu Cys Pro Gly His Glu Glu Val Pro Arg Val Asp Lys Leu Val 
            100                 105                 110         


Glu Lys Ile Leu His 
        115         


<210>  9186
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  9186

Met Met Leu Arg Val Leu Val Gly Ala Val Leu Pro Ala Met Leu Leu 
1               5                   10                  15      


Ala Ala Pro Pro Pro Ile Asn Lys Leu Ala Leu Phe Pro Asp Lys Ser 
            20                  25                  30          


Ala Trp Cys Glu Ala Lys Asn Ile Thr Gln Ile Val Gly His Ser Gly 
        35                  40                  45              


Cys Glu Ala Lys Ser Ile Gln Asn Arg Ala Cys Leu Gly Gln Cys Phe 
    50                  55                  60                  


Ser Tyr Ser Val Pro Asn Thr Phe Pro Gln Ser Thr Glu Ser Leu Val 
65                  70                  75                  80  


His Cys Asp Ser Cys Met Pro Ala Gln Ser Met Trp Glu Ile Val Thr 
                85                  90                  95      


Leu Glu Cys Pro Gly His Glu Glu Val Pro Arg Val Asp Lys Leu Val 
            100                 105                 110         


Glu Lys Ile Leu His Cys Ser Cys Gln Ala Cys Gly Lys Glu Pro Ser 
        115                 120                 125             


<210>  9187
<211>  181
<212>  PRT
<213>  Homo Sapiens

<400>  9187

Met Met Leu Arg Val Leu Val Gly Ala Val Leu Pro Ala Met Leu Leu 
1               5                   10                  15      


Ala Ala Pro Pro Pro Ile Asn Lys Leu Ala Leu Phe Pro Asp Lys Ser 
            20                  25                  30          


Ala Trp Cys Glu Ala Lys Asn Ile Thr Gln Ile Val Gly His Ser Gly 
        35                  40                  45              


Cys Glu Ala Lys Ser Ile Gln Asn Arg Ala Cys Leu Gly Gln Cys Phe 
    50                  55                  60                  


Ser Tyr Ser Val Pro Asn Thr Phe Pro Gln Ser Thr Glu Ser Leu Val 
65                  70                  75                  80  


His Cys Asp Ser Cys Met Pro Ala Gln Ser Met Trp Glu Ile Val Thr 
                85                  90                  95      


Leu Glu Cys Pro Gly His Glu Glu Val Pro Arg Val Asp Lys Leu Val 
            100                 105                 110         


Glu Lys Ile Leu His Cys Ser Cys Gln Ala Cys Gly Lys Glu Pro Ser 
        115                 120                 125             


His Glu Gly Leu Ser Val Tyr Val Gln Gly Glu Asp Gly Pro Gly Ser 
    130                 135                 140                 


Gln Pro Gly Thr His Pro His Pro His Pro His Pro His Pro Gly Gly 
145                 150                 155                 160 


Gln Thr Pro Glu Pro Glu Asp Pro Pro Gly Ala Pro His Thr Glu Glu 
                165                 170                 175     


Glu Gly Ala Glu Asp 
            180     


<210>  9188
<211>  181
<212>  PRT
<213>  Homo Sapiens

<400>  9188

Met Met Leu Arg Val Leu Val Gly Ala Val Leu Pro Ala Met Leu Leu 
1               5                   10                  15      


Ala Ala Pro Pro Pro Ile Asn Lys Leu Ala Leu Phe Pro Asp Lys Ser 
            20                  25                  30          


Ala Trp Cys Glu Ala Lys Asn Ile Thr Gln Ile Val Gly His Ser Gly 
        35                  40                  45              


Cys Glu Ala Lys Ser Ile Gln Asn Arg Ala Cys Leu Gly Gln Cys Phe 
    50                  55                  60                  


Ser Tyr Ser Val Pro Asn Thr Phe Pro Gln Ser Thr Glu Ser Leu Val 
65                  70                  75                  80  


His Cys Asp Ser Cys Met Pro Ala Gln Ser Met Trp Glu Ile Val Thr 
                85                  90                  95      


Leu Glu Cys Pro Gly His Glu Glu Val Pro Arg Val Asp Lys Leu Val 
            100                 105                 110         


Glu Lys Ile Leu His Cys Ser Cys Gln Ala Cys Gly Lys Glu Pro Ser 
        115                 120                 125             


His Glu Gly Leu Ser Val Tyr Val Gln Gly Glu Asp Gly Pro Gly Ser 
    130                 135                 140                 


Gln Pro Gly Thr His Pro His Pro His Pro His Pro His Pro Gly Gly 
145                 150                 155                 160 


Gln Thr Pro Glu Pro Glu Asp Pro Pro Gly Ala Pro His Thr Glu Glu 
                165                 170                 175     


Glu Gly Ala Glu Asp 
            180     


<210>  9189
<211>  181
<212>  PRT
<213>  Homo Sapiens

<400>  9189

Met Met Leu Arg Val Leu Val Gly Ala Val Leu Pro Ala Met Leu Leu 
1               5                   10                  15      


Ala Ala Pro Pro Pro Ile Asn Lys Leu Ala Leu Phe Pro Asp Lys Ser 
            20                  25                  30          


Ala Trp Cys Glu Ala Lys Asn Ile Thr Gln Ile Val Gly His Ser Gly 
        35                  40                  45              


Cys Glu Ala Lys Ser Ile Gln Asn Arg Ala Cys Leu Gly Gln Cys Phe 
    50                  55                  60                  


Ser Tyr Ser Val Pro Asn Thr Phe Pro Gln Ser Thr Glu Ser Leu Val 
65                  70                  75                  80  


His Cys Asp Ser Cys Met Pro Ala Gln Ser Met Trp Glu Ile Val Thr 
                85                  90                  95      


Leu Glu Cys Pro Gly His Glu Glu Val Pro Arg Val Asp Lys Leu Val 
            100                 105                 110         


Glu Lys Ile Leu His Cys Ser Cys Gln Ala Cys Gly Lys Glu Pro Ser 
        115                 120                 125             


His Glu Gly Leu Ser Val Tyr Val Gln Gly Glu Asp Gly Pro Gly Ser 
    130                 135                 140                 


Gln Pro Gly Thr His Pro His Pro His Pro His Pro His Pro Gly Gly 
145                 150                 155                 160 


Gln Thr Pro Glu Pro Glu Asp Pro Pro Gly Ala Pro His Thr Glu Glu 
                165                 170                 175     


Glu Gly Ala Glu Asp 
            180     


<210>  9190
<211>  181
<212>  PRT
<213>  Homo Sapiens

<400>  9190

Met Met Leu Arg Val Leu Val Gly Ala Val Leu Pro Ala Met Leu Leu 
1               5                   10                  15      


Ala Ala Pro Pro Pro Ile Asn Lys Leu Ala Leu Phe Pro Asp Lys Ser 
            20                  25                  30          


Ala Trp Cys Glu Ala Lys Asn Ile Thr Gln Ile Val Gly His Ser Gly 
        35                  40                  45              


Cys Glu Ala Lys Ser Ile Gln Asn Arg Ala Cys Leu Gly Gln Cys Phe 
    50                  55                  60                  


Ser Tyr Ser Val Pro Asn Thr Phe Pro Gln Ser Thr Glu Ser Leu Val 
65                  70                  75                  80  


His Cys Asp Ser Cys Met Pro Ala Gln Ser Met Trp Glu Ile Val Thr 
                85                  90                  95      


Leu Glu Cys Pro Gly His Glu Glu Val Pro Arg Val Asp Lys Leu Val 
            100                 105                 110         


Glu Lys Ile Leu His Cys Ser Cys Gln Ala Cys Gly Lys Glu Pro Ser 
        115                 120                 125             


His Glu Gly Leu Ser Val Tyr Val Gln Gly Glu Asp Gly Pro Gly Ser 
    130                 135                 140                 


Gln Pro Gly Thr His Pro His Pro His Pro His Pro His Pro Gly Gly 
145                 150                 155                 160 


Gln Thr Pro Glu Pro Glu Asp Pro Pro Gly Ala Pro His Thr Glu Glu 
                165                 170                 175     


Glu Gly Ala Glu Asp 
            180     


<210>  9191
<211>  181
<212>  PRT
<213>  Homo Sapiens

<400>  9191

Met Met Leu Arg Val Leu Val Gly Ala Val Leu Pro Ala Met Leu Leu 
1               5                   10                  15      


Ala Ala Pro Pro Pro Ile Asn Lys Leu Ala Leu Phe Pro Asp Lys Ser 
            20                  25                  30          


Ala Trp Cys Glu Ala Lys Asn Ile Thr Gln Ile Val Gly His Ser Gly 
        35                  40                  45              


Cys Glu Ala Lys Ser Ile Gln Asn Arg Ala Cys Leu Gly Gln Cys Phe 
    50                  55                  60                  


Ser Tyr Ser Val Pro Asn Thr Phe Pro Gln Ser Thr Glu Ser Leu Val 
65                  70                  75                  80  


His Cys Asp Ser Cys Met Pro Ala Gln Ser Met Trp Glu Ile Val Thr 
                85                  90                  95      


Leu Glu Cys Pro Gly His Glu Glu Val Pro Arg Val Asp Lys Leu Val 
            100                 105                 110         


Glu Lys Ile Leu His Cys Ser Cys Gln Ala Cys Gly Lys Glu Pro Ser 
        115                 120                 125             


His Glu Gly Leu Ser Val Tyr Val Gln Gly Glu Asp Gly Pro Gly Ser 
    130                 135                 140                 


Gln Pro Gly Thr His Pro His Pro His Pro His Pro His Pro Gly Gly 
145                 150                 155                 160 


Gln Thr Pro Glu Pro Glu Asp Pro Pro Gly Ala Pro His Thr Glu Glu 
                165                 170                 175     


Glu Gly Ala Glu Asp 
            180     


<210>  9192
<211>  181
<212>  PRT
<213>  Homo Sapiens

<400>  9192

Met Met Leu Arg Val Leu Val Gly Ala Val Leu Pro Ala Met Leu Leu 
1               5                   10                  15      


Ala Ala Pro Pro Pro Ile Asn Lys Leu Ala Leu Phe Pro Asp Lys Ser 
            20                  25                  30          


Ala Trp Cys Glu Ala Lys Asn Ile Thr Gln Ile Val Gly His Ser Gly 
        35                  40                  45              


Cys Glu Ala Lys Ser Ile Gln Asn Arg Ala Cys Leu Gly Gln Cys Phe 
    50                  55                  60                  


Ser Tyr Ser Val Pro Asn Thr Phe Pro Gln Ser Thr Glu Ser Leu Val 
65                  70                  75                  80  


His Cys Asp Ser Cys Met Pro Ala Gln Ser Met Trp Glu Ile Val Thr 
                85                  90                  95      


Leu Glu Cys Pro Gly His Glu Glu Val Pro Arg Val Asp Lys Leu Val 
            100                 105                 110         


Glu Lys Ile Leu His Cys Ser Cys Gln Ala Cys Gly Lys Glu Pro Ser 
        115                 120                 125             


His Glu Gly Leu Ser Val Tyr Val Gln Gly Glu Asp Gly Pro Gly Ser 
    130                 135                 140                 


Gln Pro Gly Thr His Pro His Pro His Pro His Pro His Pro Gly Gly 
145                 150                 155                 160 


Gln Thr Pro Glu Pro Glu Asp Pro Pro Gly Ala Pro His Thr Glu Glu 
                165                 170                 175     


Glu Gly Ala Glu Asp 
            180     


<210>  9193
<211>  216
<212>  PRT
<213>  Homo Sapiens

<400>  9193

Met Pro Gly Asn Leu Met Ser Gln Thr Ser Arg Ala Val Ser Ile Trp 
1               5                   10                  15      


Lys Phe Pro Ala Lys Leu Gly Lys Thr His Gly His Arg Ala Leu Glu 
            20                  25                  30          


Ala Thr Gly Met Met Leu Arg Val Leu Val Gly Ala Val Leu Pro Ala 
        35                  40                  45              


Met Leu Leu Ala Ala Pro Pro Pro Ile Asn Lys Leu Ala Leu Phe Pro 
    50                  55                  60                  


Asp Lys Ser Ala Trp Cys Glu Ala Lys Asn Ile Thr Gln Ile Val Gly 
65                  70                  75                  80  


His Ser Gly Cys Glu Ala Lys Ser Ile Gln Asn Arg Ala Cys Leu Gly 
                85                  90                  95      


Gln Cys Phe Ser Tyr Ser Val Pro Asn Thr Phe Pro Gln Ser Thr Glu 
            100                 105                 110         


Ser Leu Val His Cys Asp Ser Cys Met Pro Ala Gln Ser Met Trp Glu 
        115                 120                 125             


Ile Val Thr Leu Glu Cys Pro Gly His Glu Glu Val Pro Arg Val Asp 
    130                 135                 140                 


Lys Leu Val Glu Lys Ile Leu His Cys Ser Cys Gln Ala Cys Gly Lys 
145                 150                 155                 160 


Glu Pro Ser His Glu Gly Leu Ser Val Tyr Val Gln Gly Glu Asp Gly 
                165                 170                 175     


Pro Gly Ser Gln Pro Gly Thr His Pro His Pro His Pro His Pro His 
            180                 185                 190         


Pro Gly Gly Gln Thr Pro Glu Pro Glu Asp Pro Pro Gly Ala Pro His 
        195                 200                 205             


Thr Glu Glu Glu Gly Ala Glu Asp 
    210                 215     


<210>  9194
<211>  165
<212>  PRT
<213>  Homo Sapiens

<400>  9194

Glu Phe Ile Leu Val Gln Ala Asp Thr Pro Ser Ser Pro Ser Ile Asp 
1               5                   10                  15      


Gln Val Glu Pro Tyr Ser Ser Thr Ala Gln Val Gln Phe Asp Glu Pro 
            20                  25                  30          


Glu Ala Thr Gly Gly Val Pro Ile Leu Lys Tyr Lys Ala Glu Trp Arg 
        35                  40                  45              


Ala Val Gly Glu Glu Val Trp His Ser Lys Trp Tyr Asp Ala Lys Glu 
    50                  55                  60                  


Ala Ser Met Glu Gly Ile Val Thr Ile Val Gly Leu Lys Pro Glu Thr 
65                  70                  75                  80  


Thr Tyr Ala Val Arg Leu Ala Ala Leu Asn Gly Lys Gly Leu Gly Glu 
                85                  90                  95      


Ile Ser Ala Ala Ser Glu Phe Lys Thr Gln Pro Val His Ser Pro Pro 
            100                 105                 110         


Pro Pro Ala Ser Ala Ser Ser Ser Thr Pro Val Pro Leu Ser Pro Pro 
        115                 120                 125             


Asp Thr Thr Trp Pro Leu Pro Ala Leu Ala Thr Thr Glu Pro Ala Lys 
    130                 135                 140                 


Asn Ile Ala Gln Asn His Cys Cys Asn Met Phe Gln Ala Gly Leu His 
145                 150                 155                 160 


Asn Ala Leu Met Lys 
                165 


<210>  9195
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  9195

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
            20                  25                  30          


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
        35                  40                  45              


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
    50                  55                  60                  


Lys Thr Leu Asp Gly His Met Val Val Arg Ser His Ala Arg Val Ser 
65                  70                  75                  80  


Ser Leu Thr Leu Lys Ser Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile 
                85                  90                  95      


Cys Thr Ala Ser Asn Thr Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu 
            100                 105                 110         


Glu Val Gln Tyr Ala Pro Lys Leu Gln Gly Pro Val Ala Val Tyr Thr 
        115                 120                 125             


Trp Glu Gly Asn Gln 
    130             


<210>  9196
<211>  136
<212>  PRT
<213>  Homo Sapiens

<400>  9196

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Gly Glu Pro Ser Ala Pro Lys Leu Glu Gly Gln Met Gly Glu Asp 
            20                  25                  30          


Gly Asn Ser Ile Lys Val Asn Leu Ile Lys Gln Asp Asp Gly Gly Ser 
        35                  40                  45              


Pro Ile Arg His Tyr Leu Val Arg Tyr Arg Ala Leu Ser Ser Glu Trp 
    50                  55                  60                  


Lys Pro Glu Ile Arg Leu Pro Ser Gly Ser Asp His Val Met Leu Lys 
65                  70                  75                  80  


Ser Leu Asp Trp Asn Ala Glu Tyr Glu Val Tyr Val Val Ala Glu Asn 
                85                  90                  95      


Gln Gln Gly Lys Ser Lys Ala Ala His Phe Val Phe Arg Thr Ser Ala 
            100                 105                 110         


Gln Pro Thr Ala Ile Pro Ala Asn Gly Ser Pro Thr Ser Gly Leu Ser 
        115                 120                 125             


Thr Gly Ala Ile Val Gly Ile Leu 
    130                 135     


<210>  9197
<211>  858
<212>  PRT
<213>  Homo Sapiens

<400>  9197

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                325                 330                 335     


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
            340                 345                 350         


Lys Ala Ser Trp Thr Arg Pro Glu Lys Gln Glu Thr Leu Asp Gly His 
        355                 360                 365             


Met Val Val Arg Ser His Ala Arg Val Ser Ser Leu Thr Leu Lys Ser 
    370                 375                 380                 


Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile Cys Thr Ala Ser Asn Thr 
385                 390                 395                 400 


Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu Glu Val Gln Tyr Ala Pro 
                405                 410                 415     


Lys Leu Gln Gly Pro Val Ala Val Tyr Thr Trp Glu Gly Asn Gln Val 
            420                 425                 430         


Asn Ile Thr Cys Glu Val Phe Ala Tyr Pro Ser Ala Thr Ile Ser Trp 
        435                 440                 445             


Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser Asn Tyr Ser Asn Ile Lys 
    450                 455                 460                 


Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu Glu Val Thr Pro Asp Ser 
465                 470                 475                 480 


Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr Ala Val Asn Arg Ile Gly 
                485                 490                 495     


Gln Glu Ser Leu Glu Phe Ile Leu Val Gln Ala Asp Thr Pro Ser Ser 
            500                 505                 510         


Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser Ser Thr Ala Gln Val Gln 
        515                 520                 525             


Phe Asp Glu Pro Glu Ala Thr Gly Gly Val Pro Ile Leu Lys Tyr Lys 
    530                 535                 540                 


Ala Glu Trp Arg Ala Val Gly Glu Glu Val Trp His Ser Lys Trp Tyr 
545                 550                 555                 560 


Asp Ala Lys Glu Ala Ser Met Glu Gly Ile Val Thr Ile Val Gly Leu 
                565                 570                 575     


Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu Ala Ala Leu Asn Gly Lys 
            580                 585                 590         


Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu Phe Lys Thr Gln Pro Val 
        595                 600                 605             


Gln Gly Glu Pro Ser Ala Pro Lys Leu Glu Gly Gln Met Gly Glu Asp 
    610                 615                 620                 


Gly Asn Ser Ile Lys Val Asn Leu Ile Lys Gln Asp Asp Gly Gly Ser 
625                 630                 635                 640 


Pro Ile Arg His Tyr Leu Val Arg Tyr Arg Ala Leu Ser Ser Glu Trp 
                645                 650                 655     


Lys Pro Glu Ile Arg Leu Pro Ser Gly Ser Asp His Val Met Leu Lys 
            660                 665                 670         


Ser Leu Asp Trp Asn Ala Glu Tyr Glu Val Tyr Val Val Ala Glu Asn 
        675                 680                 685             


Gln Gln Gly Lys Ser Lys Ala Ala His Phe Val Phe Arg Thr Ser Ala 
    690                 695                 700                 


Gln Pro Thr Ala Ile Pro Ala Asn Gly Ser Pro Thr Ser Gly Leu Ser 
705                 710                 715                 720 


Thr Gly Ala Ile Val Gly Ile Leu Ile Val Ile Phe Val Leu Leu Leu 
                725                 730                 735     


Val Val Val Asp Ile Thr Cys Tyr Phe Leu Asn Lys Cys Gly Leu Phe 
            740                 745                 750         


Met Cys Ile Ala Val Asn Leu Cys Gly Lys Ala Gly Pro Gly Ala Lys 
        755                 760                 765             


Gly Lys Asp Met Glu Glu Gly Lys Ala Ala Phe Ser Lys Asp Glu Ser 
    770                 775                 780                 


Lys Glu Pro Ile Val Glu Val Arg Thr Glu Glu Glu Arg Thr Pro Asn 
785                 790                 795                 800 


His Asp Gly Gly Lys His Thr Glu Pro Asn Glu Thr Thr Pro Leu Thr 
                805                 810                 815     


Glu Pro Glu Lys Gly Pro Val Glu Ala Lys Pro Glu Cys Gln Glu Thr 
            820                 825                 830         


Glu Thr Lys Pro Ala Pro Ala Glu Val Lys Thr Val Pro Asn Asp Ala 
        835                 840                 845             


Thr Gln Thr Lys Glu Asn Glu Ser Lys Ala 
    850                 855             


<210>  9198
<211>  725
<212>  PRT
<213>  Homo Sapiens

<400>  9198

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                325                 330                 335     


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
            340                 345                 350         


Lys Thr Leu Asp Gly His Met Val Val Arg Ser His Ala Arg Val Ser 
        355                 360                 365             


Ser Leu Thr Leu Lys Ser Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile 
    370                 375                 380                 


Cys Thr Ala Ser Asn Thr Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu 
385                 390                 395                 400 


Glu Val Gln Tyr Ala Pro Lys Leu Gln Gly Pro Val Ala Val Tyr Thr 
                405                 410                 415     


Trp Glu Gly Asn Gln Val Asn Ile Thr Cys Glu Val Phe Ala Tyr Pro 
            420                 425                 430         


Ser Ala Thr Ile Ser Trp Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser 
        435                 440                 445             


Asn Tyr Ser Asn Ile Lys Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu 
    450                 455                 460                 


Glu Val Thr Pro Asp Ser Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr 
465                 470                 475                 480 


Ala Val Asn Arg Ile Gly Gln Glu Ser Leu Glu Phe Ile Leu Val Gln 
                485                 490                 495     


Ala Asp Thr Pro Ser Ser Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser 
            500                 505                 510         


Ser Thr Ala Gln Val Gln Phe Asp Glu Pro Glu Ala Thr Gly Gly Val 
        515                 520                 525             


Pro Ile Leu Lys Tyr Lys Ala Glu Trp Arg Ala Val Gly Glu Glu Val 
    530                 535                 540                 


Trp His Ser Lys Trp Tyr Asp Ala Lys Glu Ala Ser Met Glu Gly Ile 
545                 550                 555                 560 


Val Thr Ile Val Gly Leu Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu 
                565                 570                 575     


Ala Ala Leu Asn Gly Lys Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu 
            580                 585                 590         


Phe Lys Thr Gln Pro Val Arg Glu Pro Ser Ala Pro Lys Leu Glu Gly 
        595                 600                 605             


Gln Met Gly Glu Asp Gly Asn Ser Ile Lys Val Asn Leu Ile Lys Gln 
    610                 615                 620                 


Asp Asp Gly Gly Ser Pro Ile Arg His Tyr Leu Val Arg Tyr Arg Ala 
625                 630                 635                 640 


Leu Ser Ser Glu Trp Lys Pro Glu Ile Arg Leu Pro Ser Gly Ser Asp 
                645                 650                 655     


His Val Met Leu Lys Ser Leu Asp Trp Asn Ala Glu Tyr Glu Val Tyr 
            660                 665                 670         


Val Val Ala Glu Asn Gln Gln Gly Lys Ser Lys Ala Ala His Phe Val 
        675                 680                 685             


Phe Arg Thr Ser Ala Gln Pro Thr Ala Ile Pro Ala Thr Leu Gly Gly 
    690                 695                 700                 


Asn Ser Ala Ser Tyr Thr Phe Val Ser Leu Leu Phe Ser Ala Val Thr 
705                 710                 715                 720 


Leu Leu Leu Leu Cys 
                725 


<210>  9199
<211>  364
<212>  PRT
<213>  Homo Sapiens

<400>  9199

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                325                 330                 335     


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
            340                 345                 350         


Lys Ala Ser Trp Thr Arg Pro Glu Lys Gln Glu Val 
        355                 360                 


<210>  9200
<211>  761
<212>  PRT
<213>  Homo Sapiens

<400>  9200

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                325                 330                 335     


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
            340                 345                 350         


Lys Thr Leu Asp Gly His Met Val Val Arg Ser His Ala Arg Val Ser 
        355                 360                 365             


Ser Leu Thr Leu Lys Ser Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile 
    370                 375                 380                 


Cys Thr Ala Ser Asn Thr Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu 
385                 390                 395                 400 


Glu Val Gln Tyr Ala Pro Lys Leu Gln Gly Pro Val Ala Val Tyr Thr 
                405                 410                 415     


Trp Glu Gly Asn Gln Val Asn Ile Thr Cys Glu Val Phe Ala Tyr Pro 
            420                 425                 430         


Ser Ala Thr Ile Ser Trp Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser 
        435                 440                 445             


Asn Tyr Ser Asn Ile Lys Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu 
    450                 455                 460                 


Glu Val Thr Pro Asp Ser Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr 
465                 470                 475                 480 


Ala Val Asn Arg Ile Gly Gln Glu Ser Leu Glu Phe Ile Leu Val Gln 
                485                 490                 495     


Ala Asp Thr Pro Ser Ser Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser 
            500                 505                 510         


Ser Thr Ala Gln Val Gln Phe Asp Glu Pro Glu Ala Thr Gly Gly Val 
        515                 520                 525             


Pro Ile Leu Lys Tyr Lys Ala Glu Trp Arg Ala Val Gly Glu Glu Val 
    530                 535                 540                 


Trp His Ser Lys Trp Tyr Asp Ala Lys Glu Ala Ser Met Glu Gly Ile 
545                 550                 555                 560 


Val Thr Ile Val Gly Leu Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu 
                565                 570                 575     


Ala Ala Leu Asn Gly Lys Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu 
            580                 585                 590         


Phe Lys Thr Gln Pro Val His Ser Pro Pro Pro Pro Ala Ser Ala Ser 
        595                 600                 605             


Ser Ser Thr Pro Val Pro Leu Ser Pro Pro Asp Thr Thr Trp Pro Leu 
    610                 615                 620                 


Pro Ala Leu Ala Thr Thr Glu Pro Ala Lys Gly Glu Pro Ser Ala Pro 
625                 630                 635                 640 


Lys Leu Glu Gly Gln Met Gly Glu Asp Gly Asn Ser Ile Lys Val Asn 
                645                 650                 655     


Leu Ile Lys Gln Asp Asp Gly Gly Ser Pro Ile Arg His Tyr Leu Val 
            660                 665                 670         


Arg Tyr Arg Ala Leu Ser Ser Glu Trp Lys Pro Glu Ile Arg Leu Pro 
        675                 680                 685             


Ser Gly Ser Asp His Val Met Leu Lys Ser Leu Asp Trp Asn Ala Glu 
    690                 695                 700                 


Tyr Glu Val Tyr Val Val Ala Glu Asn Gln Gln Gly Lys Ser Lys Ala 
705                 710                 715                 720 


Ala His Phe Val Phe Arg Thr Ser Ala Gln Pro Thr Ala Ile Pro Ala 
                725                 730                 735     


Thr Leu Gly Gly Asn Ser Ala Ser Tyr Thr Phe Val Ser Leu Leu Phe 
            740                 745                 750         


Ser Ala Val Thr Leu Leu Leu Leu Cys 
        755                 760     


<210>  9201
<211>  848
<212>  PRT
<213>  Homo Sapiens

<400>  9201

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                325                 330                 335     


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
            340                 345                 350         


Lys Thr Leu Asp Gly His Met Val Val Arg Ser His Ala Arg Val Ser 
        355                 360                 365             


Ser Leu Thr Leu Lys Ser Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile 
    370                 375                 380                 


Cys Thr Ala Ser Asn Thr Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu 
385                 390                 395                 400 


Glu Val Gln Tyr Ala Pro Lys Leu Gln Gly Pro Val Ala Val Tyr Thr 
                405                 410                 415     


Trp Glu Gly Asn Gln Val Asn Ile Thr Cys Glu Val Phe Ala Tyr Pro 
            420                 425                 430         


Ser Ala Thr Ile Ser Trp Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser 
        435                 440                 445             


Asn Tyr Ser Asn Ile Lys Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu 
    450                 455                 460                 


Glu Val Thr Pro Asp Ser Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr 
465                 470                 475                 480 


Ala Val Asn Arg Ile Gly Gln Glu Ser Leu Glu Phe Ile Leu Val Gln 
                485                 490                 495     


Ala Asp Thr Pro Ser Ser Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser 
            500                 505                 510         


Ser Thr Ala Gln Val Gln Phe Asp Glu Pro Glu Ala Thr Gly Gly Val 
        515                 520                 525             


Pro Ile Leu Lys Tyr Lys Ala Glu Trp Arg Ala Val Gly Glu Glu Val 
    530                 535                 540                 


Trp His Ser Lys Trp Tyr Asp Ala Lys Glu Ala Ser Met Glu Gly Ile 
545                 550                 555                 560 


Val Thr Ile Val Gly Leu Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu 
                565                 570                 575     


Ala Ala Leu Asn Gly Lys Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu 
            580                 585                 590         


Phe Lys Thr Gln Pro Val Pro Gly Glu Pro Ser Ala Pro Lys Leu Glu 
        595                 600                 605             


Gly Gln Met Gly Glu Asp Gly Asn Ser Ile Lys Val Asn Leu Ile Lys 
    610                 615                 620                 


Gln Asp Asp Gly Gly Ser Pro Ile Arg His Tyr Leu Val Arg Tyr Arg 
625                 630                 635                 640 


Ala Leu Ser Ser Glu Trp Lys Pro Glu Ile Arg Leu Pro Ser Gly Ser 
                645                 650                 655     


Asp His Val Met Leu Lys Ser Leu Asp Trp Asn Ala Glu Tyr Glu Val 
            660                 665                 670         


Tyr Val Val Ala Glu Asn Gln Gln Gly Lys Ser Lys Ala Ala His Phe 
        675                 680                 685             


Val Phe Arg Thr Ser Ala Gln Pro Thr Ala Ile Pro Ala Asn Gly Ser 
    690                 695                 700                 


Pro Thr Ser Gly Leu Ser Thr Gly Ala Ile Val Gly Ile Leu Ile Val 
705                 710                 715                 720 


Ile Phe Val Leu Leu Leu Val Val Val Asp Ile Thr Cys Tyr Phe Leu 
                725                 730                 735     


Asn Lys Cys Gly Leu Phe Met Cys Ile Ala Val Asn Leu Cys Gly Lys 
            740                 745                 750         


Ala Gly Pro Gly Ala Lys Gly Lys Asp Met Glu Glu Gly Lys Ala Ala 
        755                 760                 765             


Phe Ser Lys Asp Glu Ser Lys Glu Pro Ile Val Glu Val Arg Thr Glu 
    770                 775                 780                 


Glu Glu Arg Thr Pro Asn His Asp Gly Gly Lys His Thr Glu Pro Asn 
785                 790                 795                 800 


Glu Thr Thr Pro Leu Thr Glu Pro Glu Lys Gly Pro Val Glu Ala Lys 
                805                 810                 815     


Pro Glu Cys Gln Glu Thr Glu Thr Lys Pro Ala Pro Ala Glu Val Lys 
            820                 825                 830         


Thr Val Pro Asn Asp Ala Thr Gln Thr Lys Glu Asn Glu Ser Lys Ala 
        835                 840                 845             


<210>  9202
<211>  761
<212>  PRT
<213>  Homo Sapiens

<400>  9202

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                325                 330                 335     


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
            340                 345                 350         


Lys Thr Leu Asp Gly His Met Val Val Arg Ser His Ala Arg Val Ser 
        355                 360                 365             


Ser Leu Thr Leu Lys Ser Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile 
    370                 375                 380                 


Cys Thr Ala Ser Asn Thr Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu 
385                 390                 395                 400 


Glu Val Gln Tyr Ala Pro Lys Leu Gln Gly Pro Val Ala Val Tyr Thr 
                405                 410                 415     


Trp Glu Gly Asn Gln Val Asn Ile Thr Cys Glu Val Phe Ala Tyr Pro 
            420                 425                 430         


Ser Ala Thr Ile Ser Trp Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser 
        435                 440                 445             


Asn Tyr Ser Asn Ile Lys Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu 
    450                 455                 460                 


Glu Val Thr Pro Asp Ser Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr 
465                 470                 475                 480 


Ala Val Asn Arg Ile Gly Gln Glu Ser Leu Glu Phe Ile Leu Val Gln 
                485                 490                 495     


Ala Asp Thr Pro Ser Ser Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser 
            500                 505                 510         


Ser Thr Ala Gln Val Gln Phe Asp Glu Pro Glu Ala Thr Gly Gly Val 
        515                 520                 525             


Pro Ile Leu Lys Tyr Lys Ala Glu Trp Arg Ala Val Gly Glu Glu Val 
    530                 535                 540                 


Trp His Ser Lys Trp Tyr Asp Ala Lys Glu Ala Ser Met Glu Gly Ile 
545                 550                 555                 560 


Val Thr Ile Val Gly Leu Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu 
                565                 570                 575     


Ala Ala Leu Asn Gly Lys Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu 
            580                 585                 590         


Phe Lys Thr Gln Pro Val His Ser Pro Pro Pro Pro Ala Ser Ala Ser 
        595                 600                 605             


Ser Ser Thr Pro Val Pro Leu Ser Pro Pro Asp Thr Thr Trp Pro Leu 
    610                 615                 620                 


Pro Ala Leu Ala Thr Thr Glu Pro Ala Thr Gly Glu Pro Ser Ala Pro 
625                 630                 635                 640 


Lys Leu Glu Gly Gln Met Gly Glu Asp Gly Asn Ser Ile Lys Val Asn 
                645                 650                 655     


Leu Ile Lys Gln Asp Asp Gly Gly Ser Pro Ile Arg His Tyr Leu Val 
            660                 665                 670         


Arg Tyr Arg Ala Leu Ser Ser Glu Trp Lys Pro Glu Ile Arg Leu Pro 
        675                 680                 685             


Ser Gly Ser Asp His Val Met Leu Lys Ser Leu Asp Trp Asn Ala Glu 
    690                 695                 700                 


Tyr Glu Val Tyr Val Val Ala Glu Asn Gln Gln Gly Lys Ser Lys Ala 
705                 710                 715                 720 


Ala His Phe Val Phe Arg Thr Ser Ala Gln Pro Thr Ala Ile Pro Ala 
                725                 730                 735     


Thr Leu Gly Gly Asn Ser Ala Ser Tyr Thr Phe Val Ser Leu Leu Phe 
            740                 745                 750         


Ser Ala Val Thr Leu Leu Leu Leu Cys 
        755                 760     


<210>  9203
<211>  726
<212>  PRT
<213>  Homo Sapiens

<400>  9203

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                325                 330                 335     


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
            340                 345                 350         


Lys Thr Leu Asp Gly His Met Val Val Arg Ser His Ala Arg Val Ser 
        355                 360                 365             


Ser Leu Thr Leu Lys Ser Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile 
    370                 375                 380                 


Cys Thr Ala Ser Asn Thr Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu 
385                 390                 395                 400 


Glu Val Gln Tyr Ala Pro Lys Leu Gln Gly Pro Val Ala Val Tyr Thr 
                405                 410                 415     


Trp Glu Gly Asn Gln Val Asn Ile Thr Cys Glu Val Phe Ala Tyr Pro 
            420                 425                 430         


Ser Ala Thr Ile Ser Trp Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser 
        435                 440                 445             


Asn Tyr Ser Asn Ile Lys Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu 
    450                 455                 460                 


Glu Val Thr Pro Asp Ser Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr 
465                 470                 475                 480 


Ala Val Asn Arg Ile Gly Gln Glu Ser Leu Glu Phe Ile Leu Val Gln 
                485                 490                 495     


Ala Asp Thr Pro Ser Ser Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser 
            500                 505                 510         


Ser Thr Ala Gln Val Gln Phe Asp Glu Pro Glu Ala Thr Gly Gly Val 
        515                 520                 525             


Pro Ile Leu Lys Tyr Lys Ala Glu Trp Arg Ala Val Gly Glu Glu Val 
    530                 535                 540                 


Trp His Ser Lys Trp Tyr Asp Ala Lys Glu Ala Ser Met Glu Gly Ile 
545                 550                 555                 560 


Val Thr Ile Val Gly Leu Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu 
                565                 570                 575     


Ala Ala Leu Asn Gly Lys Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu 
            580                 585                 590         


Phe Lys Thr Gln Pro Val Gln Gly Glu Pro Ser Ala Pro Lys Leu Glu 
        595                 600                 605             


Gly Gln Met Gly Glu Asp Gly Asn Ser Ile Lys Val Asn Leu Ile Lys 
    610                 615                 620                 


Gln Asp Asp Gly Gly Ser Pro Ile Arg His Tyr Leu Val Arg Tyr Arg 
625                 630                 635                 640 


Ala Leu Ser Ser Glu Trp Lys Pro Glu Ile Arg Leu Pro Ser Gly Ser 
                645                 650                 655     


Asp His Val Met Leu Lys Ser Leu Asp Trp Asn Ala Glu Tyr Glu Val 
            660                 665                 670         


Tyr Val Val Ala Glu Asn Gln Gln Gly Lys Ser Lys Ala Ala His Phe 
        675                 680                 685             


Val Phe Arg Thr Ser Ala Gln Pro Thr Ala Ile Pro Ala Thr Leu Gly 
    690                 695                 700                 


Gly Asn Ser Ala Ser Tyr Thr Phe Val Ser Leu Leu Phe Ser Ala Val 
705                 710                 715                 720 


Thr Leu Leu Leu Leu Cys 
                725     


<210>  9204
<211>  884
<212>  PRT
<213>  Homo Sapiens

<400>  9204

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                325                 330                 335     


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
            340                 345                 350         


Lys Ala Ser Trp Thr Arg Pro Glu Lys Gln Glu Val His Ala Pro Trp 
        355                 360                 365             


Asn Trp Gln Val Gly Arg Gln Lys Gly Gln Ala Gly Ser Ala Gly Phe 
    370                 375                 380                 


Pro Gly Ser His Glu Thr Leu Asp Gly His Met Val Val Arg Ser His 
385                 390                 395                 400 


Ala Arg Val Ser Ser Leu Thr Leu Lys Ser Ile Gln Tyr Thr Asp Ala 
                405                 410                 415     


Gly Glu Tyr Ile Cys Thr Ala Ser Asn Thr Ile Gly Gln Asp Ser Gln 
            420                 425                 430         


Ser Met Tyr Leu Glu Val Gln Tyr Ala Pro Lys Leu Gln Gly Pro Val 
        435                 440                 445             


Ala Val Tyr Thr Trp Glu Gly Asn Gln Val Asn Ile Thr Cys Glu Val 
    450                 455                 460                 


Phe Ala Tyr Pro Ser Ala Thr Ile Ser Trp Phe Arg Asp Gly Gln Leu 
465                 470                 475                 480 


Leu Pro Ser Ser Asn Tyr Ser Asn Ile Lys Ile Tyr Asn Thr Pro Ser 
                485                 490                 495     


Ala Ser Tyr Leu Glu Val Thr Pro Asp Ser Glu Asn Asp Phe Gly Asn 
            500                 505                 510         


Tyr Asn Cys Thr Ala Val Asn Arg Ile Gly Gln Glu Ser Leu Glu Phe 
        515                 520                 525             


Ile Leu Val Gln Ala Asp Thr Pro Ser Ser Pro Ser Ile Asp Gln Val 
    530                 535                 540                 


Glu Pro Tyr Ser Ser Thr Ala Gln Val Gln Phe Asp Glu Pro Glu Ala 
545                 550                 555                 560 


Thr Gly Gly Val Pro Ile Leu Lys Tyr Lys Ala Glu Trp Arg Ala Val 
                565                 570                 575     


Gly Glu Glu Val Trp His Ser Lys Trp Tyr Asp Ala Lys Glu Ala Ser 
            580                 585                 590         


Met Glu Gly Ile Val Thr Ile Val Gly Leu Lys Pro Glu Thr Thr Tyr 
        595                 600                 605             


Ala Val Arg Leu Ala Ala Leu Asn Gly Lys Gly Leu Gly Glu Ile Ser 
    610                 615                 620                 


Ala Ala Ser Glu Phe Lys Thr Gln Pro Val Pro Gly Glu Pro Ser Ala 
625                 630                 635                 640 


Pro Lys Leu Glu Gly Gln Met Gly Glu Asp Gly Asn Ser Ile Lys Val 
                645                 650                 655     


Asn Leu Ile Lys Gln Asp Asp Gly Gly Ser Pro Ile Arg His Tyr Leu 
            660                 665                 670         


Val Arg Tyr Arg Ala Leu Ser Ser Glu Trp Lys Pro Glu Ile Arg Leu 
        675                 680                 685             


Pro Ser Gly Ser Asp His Val Met Leu Lys Ser Leu Asp Trp Asn Ala 
    690                 695                 700                 


Glu Tyr Glu Val Tyr Val Val Ala Glu Asn Gln Gln Gly Lys Ser Lys 
705                 710                 715                 720 


Ala Ala His Phe Val Phe Arg Thr Ser Ala Gln Pro Thr Ala Ile Pro 
                725                 730                 735     


Ala Asn Gly Ser Pro Thr Ser Gly Leu Ser Thr Gly Ala Ile Val Gly 
            740                 745                 750         


Ile Leu Ile Val Ile Phe Val Leu Leu Leu Val Val Val Asp Ile Thr 
        755                 760                 765             


Cys Tyr Phe Leu Asn Lys Cys Gly Leu Phe Met Cys Ile Ala Val Asn 
    770                 775                 780                 


Leu Cys Gly Lys Ala Gly Pro Gly Ala Lys Gly Lys Asp Met Glu Glu 
785                 790                 795                 800 


Gly Lys Ala Ala Phe Ser Lys Asp Glu Ser Lys Glu Pro Ile Val Glu 
                805                 810                 815     


Val Arg Thr Glu Glu Glu Arg Thr Pro Asn His Asp Gly Gly Lys His 
            820                 825                 830         


Thr Glu Pro Asn Glu Thr Thr Pro Leu Thr Glu Pro Glu Lys Gly Pro 
        835                 840                 845             


Val Glu Ala Lys Pro Glu Cys Gln Glu Thr Glu Thr Lys Pro Ala Pro 
    850                 855                 860                 


Ala Glu Val Lys Thr Val Pro Asn Asp Ala Thr Gln Thr Lys Glu Asn 
865                 870                 875                 880 


Glu Ser Lys Ala 
                


<210>  9205
<211>  884
<212>  PRT
<213>  Homo Sapiens

<400>  9205

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                325                 330                 335     


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
            340                 345                 350         


Lys Ala Ser Trp Thr Arg Pro Glu Lys Gln Glu Val His Ala Pro Trp 
        355                 360                 365             


Asn Trp Gln Val Gly Arg Gln Lys Gly Gln Ala Gly Ser Ala Gly Phe 
    370                 375                 380                 


Pro Gly Ser His Glu Thr Leu Asp Gly His Met Val Val Arg Ser His 
385                 390                 395                 400 


Ala Arg Val Ser Ser Leu Thr Leu Lys Ser Ile Gln Tyr Thr Asp Ala 
                405                 410                 415     


Gly Glu Tyr Ile Cys Thr Ala Ser Asn Thr Ile Gly Gln Asp Ser Gln 
            420                 425                 430         


Ser Met Tyr Leu Glu Val Gln Tyr Ala Pro Lys Leu Gln Gly Pro Val 
        435                 440                 445             


Ala Val Tyr Thr Trp Glu Gly Asn Gln Val Asn Ile Thr Cys Glu Val 
    450                 455                 460                 


Phe Ala Tyr Pro Ser Ala Thr Ile Ser Trp Phe Arg Asp Gly Gln Leu 
465                 470                 475                 480 


Leu Pro Ser Ser Asn Tyr Ser Asn Ile Lys Ile Tyr Asn Thr Pro Ser 
                485                 490                 495     


Ala Ser Tyr Leu Glu Val Thr Pro Asp Ser Glu Asn Asp Phe Gly Asn 
            500                 505                 510         


Tyr Asn Cys Thr Ala Val Asn Arg Ile Gly Gln Glu Ser Leu Glu Phe 
        515                 520                 525             


Ile Leu Val Gln Ala Asp Thr Pro Ser Ser Pro Ser Ile Asp Gln Val 
    530                 535                 540                 


Glu Pro Tyr Ser Ser Thr Ala Gln Val Gln Phe Asp Glu Pro Glu Ala 
545                 550                 555                 560 


Thr Gly Gly Val Pro Ile Leu Lys Tyr Lys Ala Glu Trp Arg Ala Val 
                565                 570                 575     


Gly Glu Glu Val Trp His Ser Lys Trp Tyr Asp Ala Lys Glu Ala Ser 
            580                 585                 590         


Met Glu Gly Ile Val Thr Ile Val Gly Leu Lys Pro Glu Thr Thr Tyr 
        595                 600                 605             


Ala Val Arg Leu Ala Ala Leu Asn Gly Lys Gly Leu Gly Glu Ile Ser 
    610                 615                 620                 


Ala Ala Ser Glu Phe Lys Thr Gln Pro Val Gln Gly Glu Pro Ser Ala 
625                 630                 635                 640 


Pro Lys Leu Glu Gly Gln Met Gly Glu Asp Gly Asn Ser Ile Lys Val 
                645                 650                 655     


Asn Leu Ile Lys Gln Asp Asp Gly Gly Ser Pro Ile Arg His Tyr Leu 
            660                 665                 670         


Val Arg Tyr Arg Ala Leu Ser Ser Glu Trp Lys Pro Glu Ile Arg Leu 
        675                 680                 685             


Pro Ser Gly Ser Asp His Val Met Leu Lys Ser Leu Asp Trp Asn Ala 
    690                 695                 700                 


Glu Tyr Glu Val Tyr Val Val Ala Glu Asn Gln Gln Gly Lys Ser Lys 
705                 710                 715                 720 


Ala Ala His Phe Val Phe Arg Thr Ser Ala Gln Pro Thr Ala Ile Pro 
                725                 730                 735     


Ala Asn Gly Ser Pro Thr Ser Gly Leu Ser Thr Gly Ala Ile Val Gly 
            740                 745                 750         


Ile Leu Ile Val Ile Phe Val Leu Leu Leu Val Val Val Asp Ile Thr 
        755                 760                 765             


Cys Tyr Phe Leu Asn Lys Cys Gly Leu Phe Met Cys Ile Ala Val Asn 
    770                 775                 780                 


Leu Cys Gly Lys Ala Gly Pro Gly Ala Lys Gly Lys Asp Met Glu Glu 
785                 790                 795                 800 


Gly Lys Ala Ala Phe Ser Lys Asp Glu Ser Lys Glu Pro Ile Val Glu 
                805                 810                 815     


Val Arg Thr Glu Glu Glu Arg Thr Pro Asn His Asp Gly Gly Lys His 
            820                 825                 830         


Thr Glu Pro Asn Glu Thr Thr Pro Leu Thr Glu Pro Glu Lys Gly Pro 
        835                 840                 845             


Val Glu Ala Lys Pro Glu Cys Gln Glu Thr Glu Thr Lys Pro Ala Pro 
    850                 855                 860                 


Ala Glu Val Lys Thr Val Pro Asn Asp Ala Thr Gln Thr Lys Glu Asn 
865                 870                 875                 880 


Glu Ser Lys Ala 
                


<210>  9206
<211>  858
<212>  PRT
<213>  Homo Sapiens

<400>  9206

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                325                 330                 335     


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
            340                 345                 350         


Lys Ala Ser Trp Thr Arg Pro Glu Lys Gln Glu Thr Leu Asp Gly His 
        355                 360                 365             


Met Val Val Arg Ser His Ala Arg Val Ser Ser Leu Thr Leu Lys Ser 
    370                 375                 380                 


Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile Cys Thr Ala Ser Asn Thr 
385                 390                 395                 400 


Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu Glu Val Gln Tyr Ala Pro 
                405                 410                 415     


Lys Leu Gln Gly Pro Val Ala Val Tyr Thr Trp Glu Gly Asn Gln Val 
            420                 425                 430         


Asn Ile Thr Cys Glu Val Phe Ala Tyr Pro Ser Ala Thr Ile Ser Trp 
        435                 440                 445             


Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser Asn Tyr Ser Asn Ile Lys 
    450                 455                 460                 


Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu Glu Val Thr Pro Asp Ser 
465                 470                 475                 480 


Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr Ala Val Asn Arg Ile Gly 
                485                 490                 495     


Gln Glu Ser Leu Glu Phe Ile Leu Val Gln Ala Asp Thr Pro Ser Ser 
            500                 505                 510         


Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser Ser Thr Ala Gln Val Gln 
        515                 520                 525             


Phe Asp Glu Pro Glu Ala Thr Gly Gly Val Pro Ile Leu Lys Tyr Lys 
    530                 535                 540                 


Ala Glu Trp Arg Ala Val Gly Glu Glu Val Trp His Ser Lys Trp Tyr 
545                 550                 555                 560 


Asp Ala Lys Glu Ala Ser Met Glu Gly Ile Val Thr Ile Val Gly Leu 
                565                 570                 575     


Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu Ala Ala Leu Asn Gly Lys 
            580                 585                 590         


Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu Phe Lys Thr Gln Pro Val 
        595                 600                 605             


Pro Gly Glu Pro Ser Ala Pro Lys Leu Glu Gly Gln Met Gly Glu Asp 
    610                 615                 620                 


Gly Asn Ser Ile Lys Val Asn Leu Ile Lys Gln Asp Asp Gly Gly Ser 
625                 630                 635                 640 


Pro Ile Arg His Tyr Leu Val Arg Tyr Arg Ala Leu Ser Ser Glu Trp 
                645                 650                 655     


Lys Pro Glu Ile Arg Leu Pro Ser Gly Ser Asp His Val Met Leu Lys 
            660                 665                 670         


Ser Leu Asp Trp Asn Ala Glu Tyr Glu Val Tyr Val Val Ala Glu Asn 
        675                 680                 685             


Gln Gln Gly Lys Ser Lys Ala Ala His Phe Val Phe Arg Thr Ser Ala 
    690                 695                 700                 


Gln Pro Thr Ala Ile Pro Ala Asn Gly Ser Pro Thr Ser Gly Leu Ser 
705                 710                 715                 720 


Thr Gly Ala Ile Val Gly Ile Leu Ile Val Ile Phe Val Leu Leu Leu 
                725                 730                 735     


Val Val Val Asp Ile Thr Cys Tyr Phe Leu Asn Lys Cys Gly Leu Phe 
            740                 745                 750         


Met Cys Ile Ala Val Asn Leu Cys Gly Lys Ala Gly Pro Gly Ala Lys 
        755                 760                 765             


Gly Lys Asp Met Glu Glu Gly Lys Ala Ala Phe Ser Lys Asp Glu Ser 
    770                 775                 780                 


Lys Glu Pro Ile Val Glu Val Arg Thr Glu Glu Glu Arg Thr Pro Asn 
785                 790                 795                 800 


His Asp Gly Gly Lys His Thr Glu Pro Asn Glu Thr Thr Pro Leu Thr 
                805                 810                 815     


Glu Pro Glu Lys Gly Pro Val Glu Ala Lys Pro Glu Cys Gln Glu Thr 
            820                 825                 830         


Glu Thr Lys Pro Ala Pro Ala Glu Val Lys Thr Val Pro Asn Asp Ala 
        835                 840                 845             


Thr Gln Thr Lys Glu Asn Glu Ser Lys Ala 
    850                 855             


<210>  9207
<211>  848
<212>  PRT
<213>  Homo Sapiens

<400>  9207

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                325                 330                 335     


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
            340                 345                 350         


Lys Thr Leu Asp Gly His Met Val Val Arg Ser His Ala Arg Val Ser 
        355                 360                 365             


Ser Leu Thr Leu Lys Ser Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile 
    370                 375                 380                 


Cys Thr Ala Ser Asn Thr Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu 
385                 390                 395                 400 


Glu Val Gln Tyr Ala Pro Lys Leu Gln Gly Pro Val Ala Val Tyr Thr 
                405                 410                 415     


Trp Glu Gly Asn Gln Val Asn Ile Thr Cys Glu Val Phe Ala Tyr Pro 
            420                 425                 430         


Ser Ala Thr Ile Ser Trp Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser 
        435                 440                 445             


Asn Tyr Ser Asn Ile Lys Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu 
    450                 455                 460                 


Glu Val Thr Pro Asp Ser Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr 
465                 470                 475                 480 


Ala Val Asn Arg Ile Gly Gln Glu Ser Leu Glu Phe Ile Leu Val Gln 
                485                 490                 495     


Ala Asp Thr Pro Ser Ser Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser 
            500                 505                 510         


Ser Thr Ala Gln Val Gln Phe Asp Glu Pro Glu Ala Thr Gly Gly Val 
        515                 520                 525             


Pro Ile Leu Lys Tyr Lys Ala Glu Trp Arg Ala Val Gly Glu Glu Val 
    530                 535                 540                 


Trp His Ser Lys Trp Tyr Asp Ala Lys Glu Ala Ser Met Glu Gly Ile 
545                 550                 555                 560 


Val Thr Ile Val Gly Leu Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu 
                565                 570                 575     


Ala Ala Leu Asn Gly Lys Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu 
            580                 585                 590         


Phe Lys Thr Gln Pro Val Gln Gly Glu Pro Ser Ala Pro Lys Leu Glu 
        595                 600                 605             


Gly Gln Met Gly Glu Asp Gly Asn Ser Ile Lys Val Asn Leu Ile Lys 
    610                 615                 620                 


Gln Asp Asp Gly Gly Ser Pro Ile Arg His Tyr Leu Val Arg Tyr Arg 
625                 630                 635                 640 


Ala Leu Ser Ser Glu Trp Lys Pro Glu Ile Arg Leu Pro Ser Gly Ser 
                645                 650                 655     


Asp His Val Met Leu Lys Ser Leu Asp Trp Asn Ala Glu Tyr Glu Val 
            660                 665                 670         


Tyr Val Val Ala Glu Asn Gln Gln Gly Lys Ser Lys Ala Ala His Phe 
        675                 680                 685             


Val Phe Arg Thr Ser Ala Gln Pro Thr Ala Ile Pro Ala Asn Gly Ser 
    690                 695                 700                 


Pro Thr Ser Gly Leu Ser Thr Gly Ala Ile Val Gly Ile Leu Ile Val 
705                 710                 715                 720 


Ile Phe Val Leu Leu Leu Val Val Val Asp Ile Thr Cys Tyr Phe Leu 
                725                 730                 735     


Asn Lys Cys Gly Leu Phe Met Cys Ile Ala Val Asn Leu Cys Gly Lys 
            740                 745                 750         


Ala Gly Pro Gly Ala Lys Gly Lys Asp Met Glu Glu Gly Lys Ala Ala 
        755                 760                 765             


Phe Ser Lys Asp Glu Ser Lys Glu Pro Ile Val Glu Val Arg Thr Glu 
    770                 775                 780                 


Glu Glu Arg Thr Pro Asn His Asp Gly Gly Lys His Thr Glu Pro Asn 
785                 790                 795                 800 


Glu Thr Thr Pro Leu Thr Glu Pro Glu Lys Gly Pro Val Glu Ala Lys 
                805                 810                 815     


Pro Glu Cys Gln Glu Thr Glu Thr Lys Pro Ala Pro Ala Glu Val Lys 
            820                 825                 830         


Thr Val Pro Asn Asp Ala Thr Gln Thr Lys Glu Asn Glu Ser Lys Ala 
        835                 840                 845             


<210>  9208
<211>  229
<212>  PRT
<213>  Homo Sapiens

<400>  9208

Thr Ile Ser Trp Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser Asn Tyr 
1               5                   10                  15      


Ser Asn Ile Lys Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu Glu Val 
            20                  25                  30          


Thr Pro Asp Ser Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr Ala Val 
        35                  40                  45              


Asn Arg Ile Gly Gln Glu Ser Leu Glu Phe Ile Leu Val Gln Ala Asp 
    50                  55                  60                  


Thr Pro Ser Ser Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser Ser Thr 
65                  70                  75                  80  


Ala Gln Val Gln Phe Asp Glu Pro Glu Ala Thr Gly Gly Val Pro Ile 
                85                  90                  95      


Leu Lys Tyr Lys Ala Glu Trp Arg Ala Val Gly Glu Glu Val Trp His 
            100                 105                 110         


Ser Lys Trp Tyr Asp Ala Lys Glu Ala Ser Met Glu Gly Ile Val Thr 
        115                 120                 125             


Ile Val Gly Leu Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu Ala Ala 
    130                 135                 140                 


Leu Asn Gly Lys Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu Phe Lys 
145                 150                 155                 160 


Thr Gln Pro Val His Ser Pro Pro Pro Arg Glu Pro Ser Ala Pro Lys 
                165                 170                 175     


Leu Glu Gly Gln Met Gly Glu Asp Gly Asn Ser Ile Lys Val Asn Leu 
            180                 185                 190         


Ile Lys Gln Asp Asp Gly Gly Ser Pro Ile Arg His Tyr Leu Val Arg 
        195                 200                 205             


Tyr Arg Ala Leu Ser Ser Glu Trp Lys Pro Glu Ile Arg Leu Pro Ser 
    210                 215                 220                 


Gly Ser Asp His Val 
225                 


<210>  9209
<211>  357
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9209

Xaa Phe Ile Leu Val Gln Ala Asp Thr Pro Ser Ser Pro Ser Ile Asp 
1               5                   10                  15      


Gln Val Glu Pro Tyr Ser Ser Thr Ala Gln Val Gln Phe Asp Glu Pro 
            20                  25                  30          


Glu Ala Thr Gly Gly Val Pro Ile Leu Lys Tyr Lys Ala Glu Trp Arg 
        35                  40                  45              


Ala Val Gly Glu Glu Val Trp His Ser Lys Trp Tyr Asp Ala Lys Glu 
    50                  55                  60                  


Ala Ser Met Glu Gly Ile Val Thr Ile Val Gly Leu Lys Pro Glu Thr 
65                  70                  75                  80  


Thr Tyr Ala Val Arg Leu Ala Ala Leu Asn Gly Lys Gly Leu Gly Glu 
                85                  90                  95      


Ile Ser Ala Ala Ser Glu Phe Lys Thr Gln Pro Val Arg Glu Pro Ser 
            100                 105                 110         


Ala Pro Lys Leu Glu Gly Gln Met Gly Glu Asp Gly Asn Ser Ile Lys 
        115                 120                 125             


Val Asn Leu Ile Lys Gln Asp Asp Gly Gly Ser Pro Ile Arg His Tyr 
    130                 135                 140                 


Leu Val Arg Tyr Arg Ala Leu Ser Ser Glu Trp Lys Pro Glu Ile Arg 
145                 150                 155                 160 


Leu Pro Ser Gly Ser Asp His Val Met Leu Lys Ser Leu Asp Trp Asn 
                165                 170                 175     


Ala Glu Tyr Glu Val Tyr Val Val Ala Glu Asn Gln Gln Gly Lys Ser 
            180                 185                 190         


Lys Ala Ala His Phe Val Phe Arg Thr Ser Ala Gln Pro Thr Ala Ile 
        195                 200                 205             


Pro Ala Asn Gly Ser Pro Thr Ser Gly Leu Ser Thr Gly Ala Ile Val 
    210                 215                 220                 


Gly Ile Leu Ile Val Ile Phe Val Leu Leu Leu Val Val Val Asp Ile 
225                 230                 235                 240 


Thr Cys Tyr Phe Leu Asn Lys Cys Gly Leu Phe Met Cys Ile Ala Val 
                245                 250                 255     


Asn Leu Cys Gly Lys Ala Gly Pro Gly Ala Lys Gly Lys Asp Met Glu 
            260                 265                 270         


Glu Gly Lys Ala Ala Phe Ser Lys Asp Glu Ser Lys Glu Pro Ile Val 
        275                 280                 285             


Glu Val Arg Thr Glu Glu Glu Arg Thr Pro Asn His Asp Gly Gly Lys 
    290                 295                 300                 


His Thr Glu Pro Asn Glu Thr Thr Pro Leu Thr Glu Pro Glu Lys Gly 
305                 310                 315                 320 


Pro Val Glu Ala Lys Pro Glu Cys Gln Glu Thr Glu Thr Lys Pro Ala 
                325                 330                 335     


Pro Ala Glu Val Lys Thr Val Pro Asn Asp Ala Thr Gln Thr Lys Glu 
            340                 345                 350         


Asn Glu Ser Lys Ala 
        355         


<210>  9210
<211>  84
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9210

Xaa Gln Asp Asp Gly Gly Ser Pro Ile Arg His Tyr Leu Val Arg Tyr 
1               5                   10                  15      


Arg Ala Leu Ser Ser Glu Trp Lys Pro Glu Ile Arg Leu Pro Ser Gly 
            20                  25                  30          


Ser Asp His Val Met Leu Lys Ser Leu Asp Trp Asn Ala Glu Tyr Glu 
        35                  40                  45              


Val Tyr Val Val Ala Glu Asn Gln Gln Gly Lys Ser Lys Ala Ala His 
    50                  55                  60                  


Phe Val Phe Arg Thr Ser Ala Gln Pro Thr Ala Ile Pro Val Thr Leu 
65                  70                  75                  80  


Leu Leu Leu Cys 
                


<210>  9211
<211>  468
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9211

Xaa Ser Gly Ser Asp His Val Met Leu Lys Ser Leu Asp Trp Asn Ala 
1               5                   10                  15      


Glu Tyr Glu Val Tyr Val Val Ala Glu Asn Gln Gln Gly Lys Ser Lys 
            20                  25                  30          


Ala Ala His Phe Val Phe Arg Thr Ser Ala Gln Pro Thr Ala Ile Pro 
        35                  40                  45              


Ala Asn Gly Ser Pro Thr Ser Gly Leu Ser Thr Gly Ala Ile Val Gly 
    50                  55                  60                  


Ile Leu Ile Val Ile Phe Val Leu Leu Leu Val Val Val Asp Ile Thr 
65                  70                  75                  80  


Cys Tyr Phe Leu Asn Lys Cys Gly Leu Phe Met Cys Ile Ala Val Asn 
                85                  90                  95      


Leu Cys Gly Lys Ala Gly Pro Gly Ala Lys Gly Lys Asp Met Glu Glu 
            100                 105                 110         


Gly Lys Ala Ala Phe Ser Lys Asp Glu Ser Lys Glu Pro Ile Val Glu 
        115                 120                 125             


Val Arg Thr Glu Glu Glu Arg Thr Pro Asn His Asp Gly Gly Lys His 
    130                 135                 140                 


Thr Glu Pro Asn Glu Thr Thr Pro Leu Thr Glu Pro Glu Leu Pro Ala 
145                 150                 155                 160 


Asp Thr Thr Ala Thr Val Glu Asp Met Leu Pro Ser Val Thr Thr Val 
                165                 170                 175     


Thr Thr Asn Ser Asp Thr Ile Thr Glu Thr Phe Ala Thr Ala Gln Asn 
            180                 185                 190         


Ser Pro Thr Ser Glu Thr Thr Thr Leu Thr Ser Ser Ile Ala Pro Pro 
        195                 200                 205             


Ala Thr Ala Thr Pro Asp Ser Asn Ser Val Pro Ala Gly Gln Ala Thr 
    210                 215                 220                 


Pro Ser Lys Gly Pro Ser Ala Ser Ala Pro Ser Pro Ala Pro Ala Ser 
225                 230                 235                 240 


Ala Pro Lys Val Ala Pro Leu Val Asp Leu Ser Asp Thr Pro Thr Ser 
                245                 250                 255     


Thr Pro Ala Ala Ser Asn Leu Ser Ser Ser Val Leu Ala Asn Gln Gly 
            260                 265                 270         


Ala Val Leu Ser Pro Ser Ala Pro Ala Gly Val Gly Glu Ala Ser Lys 
        275                 280                 285             


Ala Pro Pro Ala Ser Lys Pro Thr Pro Ala Pro Val Pro Thr Pro Thr 
    290                 295                 300                 


Gly Ala Ala Ser Pro Leu Ala Ala Ala Ala Ala Pro Ala Thr Glu Ala 
305                 310                 315                 320 


Pro Gln Ala Lys Gln Glu Ala Pro Ser Thr Lys Gly Pro Asp Pro Glu 
                325                 330                 335     


Pro Thr Gln Pro Gly Ala Ala Lys Ser Pro Ala Glu Ala Ala Thr Ala 
            340                 345                 350         


Leu Ala Ser Pro Lys Ser Glu Ala Ala Ser Val Ser Thr Thr Asn Pro 
        355                 360                 365             


Ser Gln Gly Glu Asp Phe Lys Met Asp Glu Gly Asn Phe Lys Thr Pro 
    370                 375                 380                 


Asp Ile Asp Leu Ala Lys Asp Val Phe Ala Ala Leu Gly Ser Pro Ala 
385                 390                 395                 400 


Pro Ala Ala Gly Ala Ser Gly Gln Ala Pro Glu Leu Ala Pro Ser Thr 
                405                 410                 415     


Ala Asp Ser Ser Val Ser Pro Ala Pro Ala Lys Thr Glu Lys Gly Pro 
            420                 425                 430         


Val Glu Ala Lys Pro Glu Cys Gln Glu Thr Glu Thr Lys Pro Ala Pro 
        435                 440                 445             


Ala Glu Val Lys Thr Val Pro Asn Asp Ala Thr Gln Thr Lys Glu Asn 
    450                 455                 460                 


Glu Ser Lys Ala 
465             


<210>  9212
<211>  372
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9212

Xaa Thr Pro Ser Ser Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser Ser 
1               5                   10                  15      


Thr Ala Gln Val Gln Phe Asp Glu Pro Glu Ala Thr Gly Gly Val Pro 
            20                  25                  30          


Ile Leu Lys Tyr Lys Ala Glu Trp Arg Ala Val Gly Glu Glu Val Trp 
        35                  40                  45              


His Ser Lys Trp Tyr Asp Ala Lys Glu Ala Ser Met Glu Gly Ile Val 
    50                  55                  60                  


Thr Ile Val Gly Leu Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu Ala 
65                  70                  75                  80  


Ala Leu Asn Gly Lys Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu Phe 
                85                  90                  95      


Lys Thr Gln Pro Val His Ser Pro Pro Pro Pro Ala Ser Ala Ser Ser 
            100                 105                 110         


Ser Thr Pro Val Pro Leu Ser Pro Pro Asp Lys Gly Glu Pro Ser Ala 
        115                 120                 125             


Pro Lys Leu Glu Gly Gln Met Gly Glu Asp Gly Asn Ser Ile Lys Val 
    130                 135                 140                 


Asn Leu Ile Lys Gln Asp Asp Gly Gly Ser Pro Ile Arg His Tyr Leu 
145                 150                 155                 160 


Val Arg Tyr Arg Ala Leu Ser Ser Glu Trp Lys Pro Glu Ile Arg Leu 
                165                 170                 175     


Pro Ser Gly Ser Asp His Val Met Leu Lys Ser Leu Asp Trp Asn Ala 
            180                 185                 190         


Glu Tyr Glu Val Tyr Val Val Ala Glu Asn Gln Gln Gly Lys Ser Lys 
        195                 200                 205             


Ala Ala His Phe Val Phe Arg Thr Ser Ala Gln Pro Thr Ala Ile Pro 
    210                 215                 220                 


Ala Asn Gly Ser Pro Thr Ser Gly Leu Ser Thr Gly Ala Ile Val Gly 
225                 230                 235                 240 


Ile Leu Ile Val Ile Phe Val Leu Leu Leu Val Val Val Asp Ile Thr 
                245                 250                 255     


Cys Tyr Phe Leu Asn Lys Cys Gly Leu Phe Met Cys Ile Ala Val Asn 
            260                 265                 270         


Leu Cys Gly Lys Ala Gly Pro Gly Ala Lys Gly Lys Asp Met Glu Glu 
        275                 280                 285             


Gly Lys Ala Ala Phe Ser Lys Asp Glu Ser Lys Glu Pro Ile Val Glu 
    290                 295                 300                 


Val Arg Thr Glu Glu Glu Arg Thr Pro Asn His Asp Gly Gly Lys His 
305                 310                 315                 320 


Thr Glu Pro Asn Glu Thr Thr Pro Leu Thr Glu Pro Glu Lys Gly Pro 
                325                 330                 335     


Val Glu Ala Lys Pro Glu Cys Gln Glu Thr Glu Thr Lys Pro Ala Pro 
            340                 345                 350         


Ala Glu Val Lys Thr Val Pro Asn Asp Ala Thr Gln Thr Lys Glu Asn 
        355                 360                 365             


Glu Ser Lys Ala 
    370         


<210>  9213
<211>  305
<212>  PRT
<213>  Homo Sapiens

<400>  9213

Tyr Asn Thr Pro Ser Ala Ser Tyr Leu Glu Val Thr Pro Asp Ser Glu 
1               5                   10                  15      


Asn Asp Phe Gly Asn Tyr Asn Cys Thr Ala Val Asn Arg Ile Gly Gln 
            20                  25                  30          


Glu Ser Leu Glu Phe Ile Leu Val Gln Ala Asp Thr Pro Ser Ser Pro 
        35                  40                  45              


Ser Ile Asp Gln Val Glu Pro Tyr Ser Ser Thr Ala Gln Val Gln Phe 
    50                  55                  60                  


Asp Glu Pro Glu Ala Thr Gly Gly Val Pro Ile Leu Lys Tyr Lys Ala 
65                  70                  75                  80  


Glu Trp Arg Ala Val Gly Glu Glu Val Trp His Ser Lys Trp Tyr Asp 
                85                  90                  95      


Ala Lys Glu Ala Ser Met Glu Gly Ile Val Thr Ile Val Gly Leu Lys 
            100                 105                 110         


Pro Glu Thr Thr Tyr Ala Val Arg Leu Ala Ala Leu Asn Gly Lys Gly 
        115                 120                 125             


Leu Gly Glu Ile Ser Ala Ala Ser Glu Phe Lys Thr Gln Pro Val His 
    130                 135                 140                 


Ser Pro Pro Pro Pro Ala Ser Ala Ser Ser Ser Thr Pro Val Pro Leu 
145                 150                 155                 160 


Ser Pro Pro Asp Thr Thr Trp Pro Leu Pro Ala Leu Ala Thr Thr Glu 
                165                 170                 175     


Pro Ala Arg Glu Pro Ser Ala Pro Lys Leu Glu Gly Gln Met Gly Glu 
            180                 185                 190         


Asp Gly Asn Ser Ile Lys Val Asn Leu Ile Lys Gln Asp Asp Gly Gly 
        195                 200                 205             


Ser Pro Ile Arg His Tyr Leu Val Arg Tyr Arg Ala Leu Ser Ser Glu 
    210                 215                 220                 


Trp Lys Pro Glu Ile Arg Leu Pro Ser Gly Ser Asp His Val Met Leu 
225                 230                 235                 240 


Lys Ser Leu Asp Trp Asn Ala Glu Tyr Glu Val Tyr Val Val Ala Glu 
                245                 250                 255     


Asn Gln Gln Gly Lys Ser Lys Ala Ala His Phe Val Phe Arg Thr Ser 
            260                 265                 270         


Ala Gln Pro Thr Ala Ile Pro Ala Thr Leu Gly Gly Asn Ser Ala Ser 
        275                 280                 285             


Tyr Thr Phe Val Ser Leu Leu Phe Ser Ala Val Thr Leu Leu Leu Leu 
    290                 295                 300                 


Cys 
305 


<210>  9214
<211>  1321
<212>  PRT
<213>  Homo Sapiens

<400>  9214

Met Gly Ala Pro Phe Val Trp Ala Leu Gly Leu Leu Met Leu Gln Met 
1               5                   10                  15      


Leu Leu Phe Val Ala Gly Glu Gln Gly Thr Gln Asp Ile Thr Asp Ala 
            20                  25                  30          


Ser Glu Arg Gly Leu His Met Gln Lys Leu Gly Ser Gly Ser Val Gln 
        35                  40                  45              


Ala Ala Leu Ala Glu Leu Val Ala Leu Pro Cys Leu Phe Thr Leu Gln 
    50                  55                  60                  


Pro Arg Pro Ser Ala Ala Arg Asp Ala Pro Arg Ile Lys Trp Thr Lys 
65                  70                  75                  80  


Val Arg Thr Ala Ser Gly Gln Arg Gln Asp Leu Pro Ile Leu Val Ala 
                85                  90                  95      


Lys Asp Asn Val Val Arg Val Ala Lys Ser Trp Gln Gly Arg Val Ser 
            100                 105                 110         


Leu Pro Ser Tyr Pro Arg Arg Arg Ala Asn Ala Thr Leu Leu Leu Gly 
        115                 120                 125             


Pro Leu Arg Ala Ser Asp Ser Gly Leu Tyr Arg Cys Gln Val Val Arg 
    130                 135                 140                 


Gly Ile Glu Asp Glu Gln Asp Leu Val Pro Leu Glu Val Thr Gly Val 
145                 150                 155                 160 


Val Phe His Tyr Arg Ser Ala Arg Asp Arg Tyr Ala Leu Thr Phe Ala 
                165                 170                 175     


Glu Ala Gln Glu Ala Cys Arg Leu Ser Ser Ala Ile Ile Ala Ala Pro 
            180                 185                 190         


Arg His Leu Gln Ala Ala Phe Glu Asp Gly Phe Asp Asn Cys Asp Ala 
        195                 200                 205             


Gly Trp Leu Ser Asp Arg Thr Val Arg Tyr Pro Ile Thr Gln Ser Arg 
    210                 215                 220                 


Pro Gly Cys Tyr Gly Asp Arg Ser Ser Leu Pro Gly Val Arg Ser Tyr 
225                 230                 235                 240 


Gly Arg Arg Asn Pro Gln Glu Leu Tyr Asp Val Tyr Cys Phe Ala Arg 
                245                 250                 255     


Glu Leu Gly Gly Glu Val Phe Tyr Val Gly Pro Ala Arg Arg Leu Thr 
            260                 265                 270         


Leu Ala Gly Ala Arg Ala Gln Cys Arg Arg Gln Gly Ala Ala Leu Ala 
        275                 280                 285             


Ser Val Gly Gln Leu His Leu Ala Trp His Glu Gly Leu Asp Gln Cys 
    290                 295                 300                 


Asp Pro Gly Trp Leu Ala Asp Gly Ser Val Arg Tyr Pro Ile Gln Thr 
305                 310                 315                 320 


Pro Arg Arg Arg Cys Gly Gly Pro Ala Pro Gly Val Arg Thr Val Tyr 
                325                 330                 335     


Arg Phe Ala Asn Arg Thr Gly Phe Pro Ser Pro Ala Glu Arg Phe Asp 
            340                 345                 350         


Ala Tyr Cys Phe Arg Ala His His Pro Thr Ser Gln His Gly Asp Leu 
        355                 360                 365             


Glu Thr Pro Ser Ser Gly Asp Glu Gly Glu Ile Leu Ser Ala Glu Gly 
    370                 375                 380                 


Pro Pro Val Arg Glu Leu Glu Pro Thr Leu Glu Glu Glu Glu Val Val 
385                 390                 395                 400 


Thr Pro Asp Phe Gln Glu Pro Leu Val Ser Ser Gly Glu Glu Glu Thr 
                405                 410                 415     


Leu Ile Leu Glu Glu Lys Gln Glu Ser Gln Gln Thr Leu Ser Pro Thr 
            420                 425                 430         


Pro Gly Asp Pro Met Leu Ala Ser Trp Pro Thr Gly Glu Val Trp Leu 
        435                 440                 445             


Ser Thr Val Ala Pro Ser Pro Ser Asp Met Gly Ala Gly Thr Ala Ala 
    450                 455                 460                 


Ser Ser His Thr Glu Val Ala Pro Thr Asp Pro Met Pro Arg Arg Arg 
465                 470                 475                 480 


Gly Arg Phe Lys Gly Leu Asn Gly Arg Tyr Phe Gln Gln Gln Glu Pro 
                485                 490                 495     


Glu Pro Gly Leu Gln Gly Gly Met Glu Ala Ser Ala Gln Pro Pro Thr 
            500                 505                 510         


Ser Glu Ala Ala Val Asn Gln Met Glu Pro Pro Leu Ala Met Ala Val 
        515                 520                 525             


Thr Glu Met Leu Gly Ser Gly Gln Ser Arg Ser Pro Trp Ala Asp Leu 
    530                 535                 540                 


Thr Asn Glu Val Asp Met Pro Gly Ala Gly Ser Ala Gly Gly Lys Ser 
545                 550                 555                 560 


Ser Pro Glu Pro Trp Leu Trp Pro Pro Thr Met Val Pro Pro Ser Ile 
                565                 570                 575     


Ser Gly His Ser Arg Ala Pro Val Leu Glu Leu Glu Lys Ala Glu Gly 
            580                 585                 590         


Pro Ser Ala Arg Pro Ala Thr Pro Asp Leu Phe Trp Ser Pro Leu Glu 
        595                 600                 605             


Ala Thr Val Ser Ala Pro Ser Pro Ala Pro Trp Glu Ala Phe Pro Val 
    610                 615                 620                 


Ala Thr Ser Pro Asp Leu Pro Met Met Ala Met Leu Arg Gly Pro Lys 
625                 630                 635                 640 


Glu Trp Met Leu Pro His Pro Thr Pro Ile Ser Thr Glu Ala Asn Arg 
                645                 650                 655     


Val Glu Ala His Gly Glu Ala Thr Ala Thr Ala Pro Pro Ser Pro Ala 
            660                 665                 670         


Ala Glu Thr Lys Val Tyr Ser Leu Pro Leu Ser Leu Thr Pro Thr Gly 
        675                 680                 685             


Gln Gly Gly Glu Ala Met Pro Thr Thr Pro Glu Ser Pro Arg Ala Asp 
    690                 695                 700                 


Phe Arg Glu Thr Gly Glu Thr Ser Pro Ala Gln Val Asn Lys Ala Glu 
705                 710                 715                 720 


His Ser Ser Ser Ser Pro Trp Pro Ser Val Asn Arg Asn Val Ala Val 
                725                 730                 735     


Gly Phe Val Pro Thr Glu Thr Ala Thr Glu Pro Thr Gly Leu Arg Gly 
            740                 745                 750         


Ile Pro Gly Ser Glu Ser Gly Val Phe Asp Thr Ala Glu Ser Pro Thr 
        755                 760                 765             


Ser Gly Leu Gln Ala Thr Val Asp Glu Val Gln Asp Pro Trp Pro Ser 
    770                 775                 780                 


Val Tyr Ser Lys Gly Leu Asp Ala Ser Ser Pro Ser Ala Pro Leu Gly 
785                 790                 795                 800 


Ser Pro Gly Val Phe Leu Val Pro Lys Val Thr Pro Asn Leu Glu Pro 
                805                 810                 815     


Trp Val Ala Thr Asp Glu Gly Pro Thr Val Asn Pro Met Asp Ser Thr 
            820                 825                 830         


Val Thr Pro Ala Pro Ser Asp Ala Ser Gly Ile Trp Glu Pro Gly Ser 
        835                 840                 845             


Gln Val Phe Glu Glu Ala Glu Ser Thr Thr Leu Ser Pro Gln Val Ala 
    850                 855                 860                 


Leu Asp Thr Ser Ile Val Thr Pro Leu Thr Thr Leu Glu Gln Gly Asp 
865                 870                 875                 880 


Lys Val Gly Val Pro Ala Met Ser Thr Leu Gly Ser Ser Ser Ser Gln 
                885                 890                 895     


Pro His Pro Glu Pro Glu Asp Gln Val Glu Thr Gln Gly Thr Ser Gly 
            900                 905                 910         


Ala Ser Val Pro Pro His Gln Ser Ser Pro Leu Gly Lys Pro Ala Val 
        915                 920                 925             


Pro Pro Gly Thr Pro Thr Ala Ala Ser Val Gly Glu Ser Ala Ser Val 
    930                 935                 940                 


Ser Ser Gly Glu Pro Thr Val Pro Trp Asp Pro Ser Ser Thr Leu Leu 
945                 950                 955                 960 


Pro Val Thr Leu Gly Ile Glu Asp Phe Glu Leu Glu Val Leu Ala Gly 
                965                 970                 975     


Ser Pro Gly Val Glu Ser Phe Trp Glu Glu Val Ala Ser Gly Glu Glu 
            980                 985                 990         


Pro Ala Leu Pro Gly Thr Pro Met  Asn Ala Gly Ala Glu  Glu Val His 
        995                 1000                 1005             


Ser Asp  Pro Cys Glu Asn Asn  Pro Cys Leu His Gly  Gly Thr Cys 
    1010                 1015                 1020             


Asn Ala  Asn Gly Thr Met Tyr  Gly Cys Ser Cys Asp  Gln Gly Phe 
    1025                 1030                 1035             


Ala Gly  Glu Asn Cys Glu Ile  Asp Ile Asp Asp Cys  Leu Cys Ser 
    1040                 1045                 1050             


Pro Cys  Glu Asn Gly Gly Thr  Cys Ile Asp Glu Val  Asn Gly Phe 
    1055                 1060                 1065             


Val Cys  Leu Cys Leu Pro Ser  Tyr Gly Gly Ser Phe  Cys Glu Lys 
    1070                 1075                 1080             


Asp Thr  Glu Gly Cys Asp Arg  Gly Trp His Lys Phe  Gln Gly His 
    1085                 1090                 1095             


Cys Tyr  Arg Tyr Phe Ala His  Arg Arg Ala Trp Glu  Asp Ala Glu 
    1100                 1105                 1110             


Lys Asp  Cys Arg Arg Arg Ser  Gly His Leu Thr Ser  Val His Ser 
    1115                 1120                 1125             


Pro Glu  Glu His Ser Phe Ile  Asn Ser Phe Gly His  Glu Asn Thr 
    1130                 1135                 1140             


Trp Ile  Gly Leu Asn Asp Arg  Ile Val Glu Arg Asp  Phe Gln Trp 
    1145                 1150                 1155             


Thr Asp  Asn Thr Gly Leu Gln  Phe Glu Asn Trp Arg  Glu Asn Gln 
    1160                 1165                 1170             


Pro Asp  Asn Phe Phe Ala Gly  Gly Glu Asp Cys Val  Val Met Val 
    1175                 1180                 1185             


Ala His  Glu Ser Gly Arg Trp  Asn Asp Val Pro Cys  Asn Tyr Asn 
    1190                 1195                 1200             


Leu Pro  Tyr Val Cys Lys Lys  Gly Thr Val Leu Cys  Gly Pro Pro 
    1205                 1210                 1215             


Pro Ala  Val Glu Asn Ala Ser  Leu Ile Gly Ala Arg  Lys Ala Lys 
    1220                 1225                 1230             


Tyr Asn  Val His Ala Thr Val  Arg Tyr Gln Cys Asn  Glu Gly Phe 
    1235                 1240                 1245             


Ala Gln  His His Val Ala Thr  Ile Arg Cys Arg Ser  Asn Gly Lys 
    1250                 1255                 1260             


Trp Asp  Arg Pro Gln Ile Val  Cys Thr Lys Pro Arg  Arg Ser His 
    1265                 1270                 1275             


Arg Met  Arg Arg His His His  His His Gln His His  His Gln His 
    1280                 1285                 1290             


His His  His Lys Ser Arg Lys  Glu Arg Arg Lys His  Lys Lys His 
    1295                 1300                 1305             


Pro Thr  Glu Asp Trp Glu Lys  Asp Glu Gly Asn Phe  Cys 
    1310                 1315                 1320     


<210>  9215
<211>  175
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9215

Xaa Gly Cys Asp Arg Gly Trp His Lys Phe Gln Gly His Cys Tyr Arg 
1               5                   10                  15      


Tyr Phe Ala His Arg Arg Ala Trp Glu Asp Ala Glu Lys Asp Cys Arg 
            20                  25                  30          


Arg Arg Ser Gly His Leu Thr Ser Val His Ser Pro Glu Glu His Ser 
        35                  40                  45              


Phe Ile Asn Ser Phe Gly His Glu Asn Thr Trp Ile Gly Leu Asn Asp 
    50                  55                  60                  


Arg Ile Val Glu Arg Asp Phe Gln Trp Thr Asp Asn Thr Gly Leu Gln 
65                  70                  75                  80  


Phe Glu Asn Trp Arg Glu Asn Gln Pro Asp Asn Phe Phe Ala Gly Gly 
                85                  90                  95      


Glu Asp Cys Val Val Met Val Ala His Glu Ser Gly Arg Trp Asn Asp 
            100                 105                 110         


Val Pro Cys Asn Tyr Asn Leu Pro Tyr Val Cys Lys Lys Gly Thr Ala 
        115                 120                 125             


Arg Arg Ser His Arg Met Arg Arg His His His His His Gln His His 
    130                 135                 140                 


His Gln His His His His Lys Ser Arg Lys Glu Arg Arg Lys His Lys 
145                 150                 155                 160 


Lys His Pro Thr Glu Asp Trp Glu Lys Asp Glu Gly Asn Phe Cys 
                165                 170                 175 


<210>  9216
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  9216

Met Val Leu Arg Arg Leu Leu Ala Ala Leu Leu His Ser Pro Gln Leu 
1               5                   10                  15      


Val Glu Arg Leu Ser Glu Ser Arg Pro Ile Arg Arg Ala Ala Gln Leu 
            20                  25                  30          


Thr Ala Phe Ala Leu Leu Gln Ala Gln Leu Arg Gly Gln Asp Ala Ala 
        35                  40                  45              


Arg Arg Leu Gln Asp Leu Ala Ala Gly Pro Val Gly Ser Leu Cys Arg 
    50                  55                  60                  


Arg Ala Glu Arg Phe Arg Asp Ala Phe Thr Gln Glu Leu Arg Arg Gly 
65                  70                  75                  80  


Leu Arg Gly Arg Ser Gly Pro Pro Pro Gly Ser Gln Arg Gly Pro Gly 
                85                  90                  95      


Ala Asn Ile 
            


<210>  9217
<211>  709
<212>  PRT
<213>  Homo Sapiens

<400>  9217

Met Ala Thr Ala Gly Gly Gly Ser Gly Ala Asp Pro Gly Ser Arg Gly 
1               5                   10                  15      


Leu Leu Arg Leu Leu Ser Phe Cys Val Leu Leu Ala Gly Leu Cys Arg 
            20                  25                  30          


Gly Asn Ser Val Glu Arg Lys Ile Tyr Ile Pro Leu Asn Lys Thr Ala 
        35                  40                  45              


Pro Cys Val Arg Leu Leu Asn Ala Thr His Gln Ile Gly Cys Gln Ser 
    50                  55                  60                  


Ser Ile Ser Gly Asp Thr Gly Val Ile His Val Val Glu Lys Glu Glu 
65                  70                  75                  80  


Asp Leu Gln Trp Val Leu Thr Asp Gly Pro Asn Pro Pro Tyr Met Val 
                85                  90                  95      


Leu Leu Glu Ser Lys His Phe Thr Arg Asp Leu Met Glu Lys Leu Lys 
            100                 105                 110         


Gly Arg Thr Ser Arg Ile Ala Gly Leu Ala Val Ser Leu Thr Lys Pro 
        115                 120                 125             


Ser Pro Ala Ser Gly Phe Ser Pro Ser Val Gln Cys Pro Asn Asp Gly 
    130                 135                 140                 


Phe Gly Val Tyr Ser Asn Ser Tyr Gly Pro Glu Phe Ala His Cys Arg 
145                 150                 155                 160 


Glu Ile Gln Trp Asn Ser Leu Gly Asn Gly Leu Ala Tyr Glu Asp Phe 
                165                 170                 175     


Ser Phe Pro Ile Phe Leu Leu Glu Asp Glu Asn Glu Thr Lys Val Ile 
            180                 185                 190         


Lys Gln Cys Tyr Gln Asp His Asn Leu Ser Gln Asn Gly Ser Ala Pro 
        195                 200                 205             


Thr Phe Pro Leu Cys Ala Met Gln Leu Phe Ser His Met His Ala Val 
    210                 215                 220                 


Ile Ser Thr Ala Thr Cys Met Arg Arg Ser Ser Ile Gln Ser Thr Phe 
225                 230                 235                 240 


Ser Ile Asn Pro Glu Ile Val Cys Asp Pro Leu Ser Asp Tyr Asn Val 
                245                 250                 255     


Trp Ser Met Leu Lys Pro Ile Asn Thr Thr Gly Thr Leu Lys Pro Asp 
            260                 265                 270         


Asp Arg Val Val Val Ala Ala Thr Arg Leu Asp Ser Arg Ser Phe Phe 
        275                 280                 285             


Trp Asn Val Ala Pro Gly Ala Glu Ser Ala Val Ala Ser Phe Val Thr 
    290                 295                 300                 


Gln Leu Ala Ala Ala Glu Ala Leu Gln Lys Ala Pro Asp Val Thr Thr 
305                 310                 315                 320 


Leu Pro Arg Asn Val Met Phe Val Phe Phe Gln Gly Glu Thr Phe Asp 
                325                 330                 335     


Tyr Ile Gly Ser Ser Arg Met Val Tyr Asp Met Glu Lys Gly Lys Phe 
            340                 345                 350         


Pro Val Gln Leu Glu Asn Val Asp Ser Phe Val Glu Leu Gly Gln Val 
        355                 360                 365             


Ala Leu Arg Thr Ser Leu Glu Leu Trp Met His Thr Asp Pro Val Ser 
    370                 375                 380                 


Gln Lys Asn Glu Ser Val Arg Asn Gln Val Glu Asp Leu Leu Ala Thr 
385                 390                 395                 400 


Leu Glu Lys Ser Gly Ala Gly Val Pro Ala Val Ile Leu Arg Arg Pro 
                405                 410                 415     


Asn Gln Ser Gln Pro Leu Pro Pro Ser Ser Leu Gln Arg Phe Leu Arg 
            420                 425                 430         


Ala Arg Asn Ile Ser Gly Val Val Leu Ala Asp His Ser Gly Ala Phe 
        435                 440                 445             


His Asn Lys Tyr Tyr Gln Ser Ile Tyr Asp Thr Ala Glu Asn Ile Asn 
    450                 455                 460                 


Val Ser Tyr Pro Glu Trp Leu Ser Pro Glu Glu Asp Leu Asn Phe Val 
465                 470                 475                 480 


Thr Asp Thr Ala Lys Ala Leu Ala Asp Val Ala Thr Val Leu Gly Arg 
                485                 490                 495     


Ala Leu Tyr Glu Leu Ala Gly Gly Thr Asn Phe Ser Asp Thr Val Gln 
            500                 505                 510         


Ala Asp Pro Gln Thr Val Thr Arg Leu Leu Tyr Gly Phe Leu Ile Lys 
        515                 520                 525             


Ala Asn Asn Ser Trp Phe Gln Ser Ile Leu Arg Gln Asp Leu Arg Ser 
    530                 535                 540                 


Tyr Leu Gly Asp Gly Pro Leu Gln His Tyr Ile Ala Val Ser Ser Pro 
545                 550                 555                 560 


Thr Asn Thr Thr Tyr Val Val Gln Tyr Ala Leu Ala Asn Leu Thr Gly 
                565                 570                 575     


Thr Val Val Asn Leu Thr Arg Glu Gln Cys Gln Asp Pro Ser Lys Val 
            580                 585                 590         


Pro Ser Glu Asn Lys Asp Leu Tyr Glu Tyr Ser Trp Val Gln Gly Pro 
        595                 600                 605             


Leu His Ser Asn Glu Thr Asp Arg Leu Pro Arg Cys Val Arg Ser Thr 
    610                 615                 620                 


Ala Arg Leu Ala Arg Ala Leu Ser Pro Ala Phe Glu Leu Ser Gln Trp 
625                 630                 635                 640 


Ser Ser Thr Glu Tyr Ser Thr Trp Thr Glu Ser Arg Trp Lys Asp Ile 
                645                 650                 655     


Arg Ala Arg Ile Phe Leu Ile Ala Ser Lys Glu Leu Glu Leu Ile Thr 
            660                 665                 670         


Leu Thr Val Gly Phe Gly Ile Leu Ile Phe Ser Leu Ile Val Thr Tyr 
        675                 680                 685             


Cys Ile Asn Ala Lys Ala Asp Val Leu Phe Ile Ala Pro Arg Glu Pro 
    690                 695                 700                 


Gly Ala Val Ser Tyr 
705                 


<210>  9218
<211>  255
<212>  PRT
<213>  Homo Sapiens

<400>  9218

Met Ala Thr Ala Gly Gly Gly Ser Gly Ala Asp Pro Gly Ser Arg Gly 
1               5                   10                  15      


Leu Leu Arg Leu Leu Ser Phe Cys Val Leu Leu Ala Gly Leu Cys Arg 
            20                  25                  30          


Gly Asn Ser Val Glu Arg Lys Ile Tyr Ile Pro Leu Asn Lys Thr Ala 
        35                  40                  45              


Pro Cys Val Arg Leu Leu Asn Ala Thr His Gln Ile Gly Cys Gln Ser 
    50                  55                  60                  


Ser Ile Ser Gly Asp Thr Gly Val Ile His Val Val Glu Lys Glu Glu 
65                  70                  75                  80  


Asp Leu Gln Trp Val Leu Thr Asp Gly Pro Asn Pro Pro Tyr Met Val 
                85                  90                  95      


Leu Leu Glu Ser Lys His Phe Thr Arg Asp Leu Met Glu Lys Leu Lys 
            100                 105                 110         


Gly Arg Thr Ser Arg Ile Ala Gly Leu Ala Val Ser Leu Thr Lys Pro 
        115                 120                 125             


Ser Pro Ala Ser Gly Phe Ser Pro Ser Val Gln Cys Pro Asn Asp Gly 
    130                 135                 140                 


Phe Gly Val Tyr Ser Asn Ser Tyr Gly Pro Glu Phe Ala His Cys Arg 
145                 150                 155                 160 


Glu Ile Gln Trp Asn Ser Leu Gly Asn Gly Leu Ala Tyr Glu Asp Phe 
                165                 170                 175     


Ser Phe Pro Ile Phe Leu Leu Glu Asp Glu Asn Glu Thr Lys Val Ile 
            180                 185                 190         


Lys Gln Glu Thr Phe Asp Tyr Ile Gly Ser Ser Arg Met Val Tyr Asp 
        195                 200                 205             


Met Glu Lys Gly Lys Phe Pro Val Gln Leu Glu Asn Val Asp Ser Phe 
    210                 215                 220                 


Val Glu Leu Gly Gln Val Ala Leu Arg Thr Ser Leu Glu Leu Trp Met 
225                 230                 235                 240 


His Thr Asp Pro Val Ser Gln Lys Asn Glu Ser Val Arg Asn Gln 
                245                 250                 255 


<210>  9219
<211>  134
<212>  PRT
<213>  Homo Sapiens

<400>  9219

Met Ala Thr Ala Gly Gly Gly Ser Gly Ala Asp Pro Gly Ser Arg Gly 
1               5                   10                  15      


Leu Leu Arg Leu Leu Ser Phe Cys Val Leu Leu Ala Gly Leu Cys Arg 
            20                  25                  30          


Gly Asn Ser Val Glu Arg Lys Ile Tyr Ile Pro Leu Asn Lys Thr Ala 
        35                  40                  45              


Pro Cys Val Arg Leu Leu Asn Ala Thr His Gln Ile Gly Cys Gln Ser 
    50                  55                  60                  


Ser Ile Ser Gly Asp Thr Gly Val Ile His Val Val Glu Lys Glu Glu 
65                  70                  75                  80  


Asp Leu Gln Trp Val Leu Thr Asp Gly Pro Asn Pro Pro Tyr Met Val 
                85                  90                  95      


Leu Leu Glu Ser Lys His Phe Thr Arg Gln Asn Val Arg Leu Ser Asp 
            100                 105                 110         


Thr Phe Leu Cys Ser Phe Met Glu Phe Leu Ser Tyr Ser Arg Asp Leu 
        115                 120                 125             


Met Glu Lys Leu Lys Gly 
    130                 


<210>  9220
<211>  232
<212>  PRT
<213>  Homo Sapiens

<400>  9220

Met Ala Thr Ala Gly Gly Gly Ser Gly Ala Asp Pro Gly Ser Arg Gly 
1               5                   10                  15      


Leu Leu Arg Leu Leu Ser Phe Cys Val Leu Leu Ala Gly Leu Phe Leu 
            20                  25                  30          


Asp Phe Glu Pro Asp Pro Leu Pro Leu Cys Pro Asp Val Ser Phe Phe 
        35                  40                  45              


Pro Gln Pro Gln Pro Pro Thr Pro Gln Ser Lys Gly Thr Gly Leu Cys 
    50                  55                  60                  


Arg Gly Asn Ser Val Glu Arg Lys Ile Tyr Ile Pro Leu Asn Lys Thr 
65                  70                  75                  80  


Ala Pro Cys Val Arg Leu Leu Asn Ala Thr His Gln Ile Gly Cys Gln 
                85                  90                  95      


Ser Ser Ile Ser Gly Asp Thr Gly Val Ile His Val Val Glu Lys Glu 
            100                 105                 110         


Glu Asp Leu Gln Trp Val Leu Thr Asp Gly Pro Asn Pro Pro Tyr Met 
        115                 120                 125             


Val Leu Leu Glu Ser Lys His Phe Thr Arg Asp Leu Met Glu Lys Leu 
    130                 135                 140                 


Lys Gly Arg Thr Ser Arg Ile Ala Gly Leu Ala Val Ser Leu Thr Lys 
145                 150                 155                 160 


Pro Ser Pro Ala Ser Gly Phe Ser Pro Ser Val Gln Cys Pro Asn Asp 
                165                 170                 175     


Gly Phe Gly Val Tyr Ser Asn Ser Tyr Gly Pro Glu Phe Ala His Cys 
            180                 185                 190         


Arg Glu Ile Gln Trp Asn Ser Leu Gly Asn Gly Leu Ala Tyr Glu Asp 
        195                 200                 205             


Phe Ser Phe Pro Ile Phe Leu Leu Glu Asp Glu Asn Glu Thr Lys Val 
    210                 215                 220                 


Ile Lys Gln Cys Tyr Gln Asp His 
225                 230         


<210>  9221
<211>  71
<212>  PRT
<213>  Homo Sapiens

<400>  9221

Met Ala Thr Ala Gly Gly Gly Ser Gly Ala Asp Pro Gly Ser Arg Gly 
1               5                   10                  15      


Leu Leu Arg Leu Leu Ser Phe Cys Val Leu Leu Ala Gly Leu Phe Leu 
            20                  25                  30          


Asp Phe Glu Pro Asp Pro Leu Pro Leu Cys Pro Asp Val Ser Phe Phe 
        35                  40                  45              


Pro Gln Pro Gln Pro Pro Thr Pro Gln Ser Lys Gly Thr Gly Val Lys 
    50                  55                  60                  


Val Ser Phe Leu Pro Arg Val 
65                  70      


<210>  9222
<211>  69
<212>  PRT
<213>  Homo Sapiens

<400>  9222

Met Ala Thr Ala Gly Gly Gly Ser Gly Ala Asp Pro Gly Ser Arg Gly 
1               5                   10                  15      


Leu Leu Arg Leu Leu Ser Phe Cys Val Leu Leu Ala Val Ser Leu Ser 
            20                  25                  30          


Met Ala Leu His Gly Leu Cys Asn Asn Pro Leu Arg His Ile Ala Gly 
        35                  40                  45              


Cys His Val Glu His Val Ser Val Thr Ile Ser Val Cys Pro Arg Asn 
    50                  55                  60                  


Gln Lys Asn Gly Leu 
65                  


<210>  9223
<211>  219
<212>  PRT
<213>  Homo Sapiens

<400>  9223

Arg Ser Ser Ile Gln Ser Thr Phe Ser Ile Asn Pro Glu Ile Val Cys 
1               5                   10                  15      


Asp Pro Leu Ser Asp Tyr Asn Val Trp Ser Met Leu Lys Pro Ile Asn 
            20                  25                  30          


Thr Thr Gly Thr Leu Lys Pro Asp Asp Arg Val Val Val Ala Ala Thr 
        35                  40                  45              


Arg Leu Ala Ala Ala Glu Ala Leu Gln Lys Ala Pro Asp Val Thr Thr 
    50                  55                  60                  


Leu Pro Arg Asn Val Met Phe Val Phe Phe Gln Gly Glu Thr Phe Asp 
65                  70                  75                  80  


Tyr Ile Gly Ser Ser Arg Met Val Tyr Asp Met Glu Lys Gly Lys Phe 
                85                  90                  95      


Pro Val Gln Leu Glu Asn Val Asp Ser Phe Val Glu Leu Gly Gln Val 
            100                 105                 110         


Ala Leu Arg Thr Ser Leu Glu Leu Trp Met His Thr Asp Pro Val Ser 
        115                 120                 125             


Gln Lys Asn Glu Ser Val Arg Asn Gln Val Glu Asp Leu Leu Ala Thr 
    130                 135                 140                 


Leu Glu Lys Ser Gly Ala Gly Val Pro Ala Val Ile Leu Arg Arg Pro 
145                 150                 155                 160 


Asn Gln Ser Gln Pro Leu Pro Pro Ser Ser Leu Gln Arg Phe Leu Arg 
                165                 170                 175     


Ala Arg Asn Ile Ser Gly Val Val Leu Ala Asp His Ser Gly Ala Phe 
            180                 185                 190         


His Asn Lys Tyr Tyr Gln Ser Ile Tyr Asp Thr Ala Glu Asn Ile Asn 
        195                 200                 205             


Val Ser Tyr Pro Glu Trp Leu Ser Pro Glu Glu 
    210                 215                 


<210>  9224
<211>  69
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9224

Xaa Asn Asp Gly Phe Gly Val Tyr Ser Asn Ser Tyr Gly Pro Glu Phe 
1               5                   10                  15      


Ala His Cys Arg Glu Ile Gln Trp Asn Ser Leu Gly Asn Gly Leu Ala 
            20                  25                  30          


Tyr Glu Asp Phe Ser Phe Pro Ile Phe Leu Leu Glu Asp Glu Asn Glu 
        35                  40                  45              


Thr Lys Val Ile Lys Gln Lys Ser Ser Val Thr Pro Cys Leu Ile Thr 
    50                  55                  60                  


Met Cys Gly Ala Cys 
65                  


<210>  9225
<211>  275
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9225

Xaa Asn Val Ala Pro Gly Ala Glu Ser Ala Val Ala Ser Phe Val Thr 
1               5                   10                  15      


Gln Leu Ala Ala Ala Glu Ala Leu Gln Lys Ala Pro Asp Val Thr Thr 
            20                  25                  30          


Leu Pro Arg Asn Val Met Phe Val Phe Phe Gln Gly Val Ala Leu Arg 
        35                  40                  45              


Thr Ser Leu Glu Leu Trp Met His Thr Asp Pro Val Ser Gln Lys Asn 
    50                  55                  60                  


Glu Ser Val Arg Asn Gln Val Glu Asp Leu Leu Ala Thr Leu Glu Lys 
65                  70                  75                  80  


Ser Gly Ala Gly Val Pro Ala Val Ile Leu Arg Arg Pro Asn Gln Ser 
                85                  90                  95      


Gln Pro Leu Pro Pro Ser Ser Leu Gln Arg Phe Leu Arg Ala Arg Asn 
            100                 105                 110         


Ile Ser Gly Val Val Leu Ala Asp His Ser Gly Ala Phe His Asn Lys 
        115                 120                 125             


Tyr Tyr Gln Ser Ile Tyr Asp Thr Ala Glu Asn Ile Asn Val Ser Tyr 
    130                 135                 140                 


Pro Glu Trp Leu Ser Pro Glu Glu Asp Leu Asn Phe Val Thr Asp Thr 
145                 150                 155                 160 


Ala Lys Ala Leu Ala Asp Val Ala Thr Val Leu Gly Arg Ala Leu Tyr 
                165                 170                 175     


Glu Leu Ala Gly Gly Thr Asn Phe Ser Asp Thr Val Gln Ala Asp Pro 
            180                 185                 190         


Gln Thr Val Thr Arg Leu Leu Tyr Gly Phe Leu Ile Lys Ala Asn Asn 
        195                 200                 205             


Ser Trp Phe Gln Ser Ile Leu Arg Gln Asp Leu Arg Ser Tyr Leu Gly 
    210                 215                 220                 


Asp Gly Pro Leu Gln His Tyr Ile Ala Val Ser Ser Pro Thr Asn Thr 
225                 230                 235                 240 


Thr Tyr Val Val Gln Tyr Ala Leu Ala Asn Leu Thr Gly Thr Val Val 
                245                 250                 255     


Asn Leu Thr Arg Glu Gln Cys Gln Asp Pro Ser Lys Val Pro Ser Glu 
            260                 265                 270         


Asn Lys Asp 
        275 


<210>  9226
<211>  317
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9226

Xaa Val Tyr Ser Asn Ser Tyr Gly Pro Glu Phe Ala His Cys Arg Glu 
1               5                   10                  15      


Ile Gln Trp Asn Ser Leu Gly Asn Gly Leu Ala Tyr Glu Asp Phe Ser 
            20                  25                  30          


Phe Pro Ile Phe Leu Leu Glu Asp Glu Asn Glu Thr Lys Val Ile Lys 
        35                  40                  45              


Gln Leu Phe Ser His Met His Ala Val Ile Ser Thr Ala Thr Cys Met 
    50                  55                  60                  


Arg Arg Ser Ser Ile Gln Ser Thr Phe Ser Ile Asn Pro Glu Ile Val 
65                  70                  75                  80  


Cys Asp Pro Leu Ser Asp Tyr Asn Val Trp Ser Met Leu Lys Pro Ile 
                85                  90                  95      


Asn Thr Thr Gly Thr Leu Lys Pro Asp Asp Arg Val Val Val Ala Ala 
            100                 105                 110         


Thr Arg Leu Asp Ser Arg Ser Phe Phe Trp Asn Val Ala Pro Gly Ala 
        115                 120                 125             


Glu Ser Ala Val Ala Ser Phe Val Thr Gln Leu Ala Ala Ala Glu Ala 
    130                 135                 140                 


Leu Gln Lys Ala Pro Asp Val Thr Thr Leu Pro Arg Asn Val Met Phe 
145                 150                 155                 160 


Val Phe Phe Gln Gly Glu Thr Phe Asp Tyr Ile Gly Ser Ser Arg Met 
                165                 170                 175     


Val Tyr Asp Met Glu Lys Gly Lys Phe Pro Val Gln Leu Glu Asn Val 
            180                 185                 190         


Asp Ser Phe Val Glu Leu Gly Gln Val Ala Leu Arg Thr Ser Leu Glu 
        195                 200                 205             


Leu Trp Met His Thr Asp Pro Val Ser Gln Lys Asn Glu Ser Val Arg 
    210                 215                 220                 


Asn Gln Val Glu Asp Leu Leu Ala Thr Leu Glu Lys Ser Gly Ala Gly 
225                 230                 235                 240 


Val Pro Ala Val Ile Leu Arg Arg Pro Asn Gln Ser Gln Pro Leu Pro 
                245                 250                 255     


Pro Ser Ser Leu Gln Arg Phe Leu Arg Ala Arg Asn Ile Ser Gly Val 
            260                 265                 270         


Val Leu Ala Asp His Ser Gly Ala Phe His Asn Lys Tyr Tyr Gln Ser 
        275                 280                 285             


Ile Tyr Asp Thr Ala Glu Asn Ile Asn Val Ser Tyr Pro Glu Trp Leu 
    290                 295                 300                 


Ser Pro Glu Glu Asp Leu Asn Phe Val Thr Asp Thr Ala 
305                 310                 315         


<210>  9227
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  9227

Met Val Leu Leu His Trp Cys Leu Leu Trp Leu Leu Phe Pro Leu Ser 
1               5                   10                  15      


Ser Arg Thr Gln Lys Leu Pro Thr Arg Asp Glu Glu Leu Phe Gln Met 
            20                  25                  30          


Gln Ile Arg Asp Lys Ala Phe Phe His Asp Ser Ser Val Ile Pro Asp 
        35                  40                  45              


Gly Ala Glu Ile Ser Ser Tyr Leu Phe Arg Asp Thr Pro Lys Arg Tyr 
    50                  55                  60                  


Phe Phe Val Val Glu Glu Asp Asn Thr Pro Leu Ser Val Thr Val Thr 
65                  70                  75                  80  


Pro Cys Asp Ala Pro Leu Glu Trp Lys Leu Ser Leu Gln Glu Leu Pro 
                85                  90                  95      


Glu Asp Arg Ser Gly Glu Gly Ser Gly Asp Leu Glu Pro Leu Glu Gln 
            100                 105                 110         


Gln Lys Gln Gln 
        115     


<210>  9228
<211>  145
<212>  PRT
<213>  Homo Sapiens

<400>  9228

Met Val Leu Leu His Trp Cys Leu Leu Trp Leu Leu Phe Pro Leu Ser 
1               5                   10                  15      


Ser Arg Thr Gln Lys Leu Pro Thr Arg Asp Glu Glu Leu Phe Gln Met 
            20                  25                  30          


Gln Ile Arg Asp Lys Ala Phe Phe His Asp Ser Ser Val Ile Pro Asp 
        35                  40                  45              


Gly Ala Glu Ile Ser Ser Tyr Leu Phe Arg Asp Thr Pro Lys Arg Tyr 
    50                  55                  60                  


Phe Phe Val Val Glu Glu Asp Asn Thr Pro Leu Ser Val Thr Val Thr 
65                  70                  75                  80  


Pro Cys Asp Ala Pro Leu Glu Trp Lys Leu Ser Leu Gln Glu Leu Pro 
                85                  90                  95      


Glu Asp Arg Ser Gly Glu Gly Ser Gly Asp Leu Glu Pro Leu Glu Gln 
            100                 105                 110         


Gln Lys Gln Gln Ile Ile Asn Glu Glu Gly Thr Glu Leu Phe Ser Tyr 
        115                 120                 125             


Lys Gly Asn Asp Val Glu Tyr Phe Ile Ser Ser Ser Ser Pro Ser Gly 
    130                 135                 140                 


Leu 
145 


<210>  9229
<211>  568
<212>  PRT
<213>  Homo Sapiens

<400>  9229

Met Val Leu Leu His Trp Cys Leu Leu Trp Leu Leu Phe Pro Leu Ser 
1               5                   10                  15      


Ser Arg Thr Gln Lys Leu Pro Thr Arg Asp Glu Glu Leu Phe Gln Met 
            20                  25                  30          


Gln Ile Arg Asp Lys Ala Phe Phe His Asp Ser Ser Val Ile Pro Asp 
        35                  40                  45              


Gly Ala Glu Ile Ser Ser Tyr Leu Phe Arg Asp Thr Pro Lys Arg Tyr 
    50                  55                  60                  


Phe Phe Val Val Glu Glu Asp Asn Thr Pro Leu Ser Val Thr Val Thr 
65                  70                  75                  80  


Pro Cys Asp Ala Pro Leu Glu Trp Lys Leu Ser Leu Gln Glu Leu Pro 
                85                  90                  95      


Glu Asp Arg Ser Gly Glu Gly Ser Gly Asp Leu Glu Pro Leu Glu Gln 
            100                 105                 110         


Gln Lys Gln Gln Ile Ile Asn Glu Glu Gly Thr Glu Leu Phe Ser Tyr 
        115                 120                 125             


Lys Gly Asn Asp Val Glu Tyr Phe Ile Ser Ser Ser Ser Pro Ser Gly 
    130                 135                 140                 


Leu Tyr Gln Leu Asp Leu Leu Ser Thr Glu Lys Asp Thr His Phe Lys 
145                 150                 155                 160 


Val Tyr Ala Thr Thr Thr Pro Glu Ser Asp Gln Pro Tyr Pro Glu Leu 
                165                 170                 175     


Pro Tyr Asp Pro Arg Val Asp Val Thr Ser Leu Gly Arg Thr Thr Val 
            180                 185                 190         


Thr Leu Ala Trp Lys Pro Ser Pro Thr Ala Ser Leu Leu Lys Gln Pro 
        195                 200                 205             


Ile Gln Tyr Cys Val Val Ile Asn Lys Glu His Asn Phe Lys Ser Leu 
    210                 215                 220                 


Cys Ala Val Glu Ala Lys Leu Ser Ala Asp Asp Ala Phe Met Met Ala 
225                 230                 235                 240 


Pro Lys Pro Gly Leu Asp Phe Ser Pro Phe Asp Phe Ala His Phe Gly 
                245                 250                 255     


Phe Pro Ser Asp Asn Ser Gly Lys Glu Arg Ser Phe Gln Ala Lys Pro 
            260                 265                 270         


Ser Pro Lys Leu Gly Arg His Val Tyr Ser Arg Pro Lys Val Asp Ile 
        275                 280                 285             


Gln Lys Ile Cys Ile Gly Asn Lys Asn Ile Phe Thr Val Ser Asp Leu 
    290                 295                 300                 


Lys Pro Asp Thr Gln Tyr Tyr Phe Asp Val Phe Val Val Asn Ile Asn 
305                 310                 315                 320 


Ser Asn Met Ser Thr Ala Tyr Val Gly Thr Phe Ala Arg Thr Lys Glu 
                325                 330                 335     


Glu Ala Lys Gln Lys Thr Val Glu Leu Lys Asp Gly Lys Ile Thr Asp 
            340                 345                 350         


Val Phe Val Lys Arg Lys Gly Ala Lys Phe Leu Arg Phe Ala Pro Val 
        355                 360                 365             


Ser Ser His Gln Lys Val Thr Phe Phe Ile His Ser Cys Leu Asp Ala 
    370                 375                 380                 


Val Gln Ile Gln Val Arg Arg Asp Gly Lys Leu Leu Leu Ser Gln Asn 
385                 390                 395                 400 


Val Glu Gly Ile Gln Gln Phe Gln Leu Arg Gly Lys Pro Lys Ala Lys 
                405                 410                 415     


Tyr Leu Val Arg Leu Lys Gly Asn Lys Lys Gly Ala Ser Met Leu Lys 
            420                 425                 430         


Ile Leu Ala Thr Thr Arg Pro Thr Lys Gln Ser Phe Pro Ser Leu Pro 
        435                 440                 445             


Glu Asp Thr Arg Ile Lys Ala Phe Asp Lys Leu Arg Thr Cys Ser Ser 
    450                 455                 460                 


Ala Thr Val Ala Trp Leu Gly Thr Gln Glu Arg Asn Lys Phe Cys Ile 
465                 470                 475                 480 


Tyr Lys Lys Glu Val Asp Asp Asn Tyr Asn Glu Asp Gln Lys Lys Arg 
                485                 490                 495     


Glu Gln Asn Gln Cys Leu Gly Pro Asp Ile Arg Lys Lys Ser Glu Lys 
            500                 505                 510         


Val Leu Cys Lys Tyr Phe His Ser Gln Asn Leu Gln Lys Ala Val Thr 
        515                 520                 525             


Thr Glu Thr Ile Lys Gly Leu Gln Pro Gly Lys Ser Tyr Leu Leu Asp 
    530                 535                 540                 


Val Tyr Val Ile Gly His Gly Gly His Ser Val Lys Tyr Gln Ser Lys 
545                 550                 555                 560 


Val Val Lys Thr Arg Lys Phe Cys 
                565             


<210>  9230
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  9230

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  9231
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  9231

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  9232
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  9232

Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu Leu 
1               5                   10                  15      


Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe Ile Met 
            20                  25                  30          


Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val Asp Ser Ile 
        35                  40                  45              


Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu Ala Arg 
    50                  55                  60                  


Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro Leu Val Ser 
65                  70                  75                  80  


Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser Cys His Cys Cys 
                85                  90                  95      


Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg Leu Arg Cys Ser Gly 
            100                 105                 110         


Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr Ile Leu Ser Cys His Cys 
        115                 120                 125             


Glu Glu Cys Asn Ser 
    130             


<210>  9233
<211>  129
<212>  PRT
<213>  Homo Sapiens

<400>  9233

Asp Ile Glu Asn Ala Tyr Lys Lys Thr Phe Leu Pro Glu Met Ser Glu 
1               5                   10                  15      


Lys Cys Glu Val Leu Gln Tyr Ser Ala Arg Glu Ala Gln Asp Ser Lys 
            20                  25                  30          


Lys Val Val Glu Asp Ile Glu Tyr Leu Lys Phe Asp Lys Gly Pro Trp 
        35                  40                  45              


Leu Lys Gln Asp Asn Arg Thr Leu Tyr His Leu Arg Leu Leu Val Gln 
    50                  55                  60                  


Asp Lys Phe Glu Val Leu Asn Tyr Thr Ser Ile Pro Ile Phe Leu Pro 
65                  70                  75                  80  


Glu Val Thr Ile Gly Ala His Gln Thr Asp Arg Val Leu His Gln Phe 
                85                  90                  95      


Arg Glu Val Pro Ala Asp Gln Glu His Arg Trp Val Ser Leu Leu Ser 
            100                 105                 110         


Ser Pro Leu Gly Ser Leu Phe Ser Glu Trp Ser Val Cys Gly Glu Asp 
        115                 120                 125             


Ser 
    


<210>  9234
<211>  138
<212>  PRT
<213>  Homo Sapiens

<400>  9234

Glu Asn Ala Tyr Lys Lys Thr Phe Leu Pro Glu Met Ser Glu Lys Cys 
1               5                   10                  15      


Glu Val Leu Gln Tyr Ser Ala Arg Glu Ala Gln Asp Ser Lys Lys Val 
            20                  25                  30          


Val Glu Asp Ile Glu Tyr Leu Lys Phe Asp Lys Gly Pro Trp Leu Lys 
        35                  40                  45              


Gln Asp Asn Arg Thr Leu Tyr His Leu Arg Leu Leu Val Gln Asp Lys 
    50                  55                  60                  


Phe Glu Val Leu Asn Tyr Thr Ser Ile Pro Ile Phe Leu Pro Glu Val 
65                  70                  75                  80  


Thr Ile Gly Ala His Gln Thr Asp Arg Val Leu His Gln Phe Arg Glu 
                85                  90                  95      


Phe Ser Leu Phe Asn Gly Arg Lys Pro Asp Ala Val Lys Ile Leu Cys 
            100                 105                 110         


Ser Leu Leu Glu Ala Asp Arg Ser Leu Leu Glu Ala Asp Arg Ser Leu 
        115                 120                 125             


Leu Glu Ala Asp Arg Val Gln Asp Ser Cys 
    130                 135             


<210>  9235
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  9235

Met Ala Leu Arg Leu Leu Lys Leu Ala Ala Thr Ser Ala Ser Ala Arg 
1               5                   10                  15      


Val Val Ala Ala Gly Ala Gln Arg Val Ala Ser Ser Thr Phe Leu Lys 
            20                  25                  30          


Arg Gly Phe Ile Ile Gln Thr Val Pro Gln Glu Met Gly Ser Pro Ser 
        35                  40                  45              


Pro Pro Thr Ile Met Ala Thr Val Val Trp Arg Asn Phe Thr Met Ile 
    50                  55                  60                  


Arg Glu Ala Met Met Ala Thr Val Thr Ala Cys Ser Pro Gly Cys Thr 
65                  70                  75                  80  


Ala Val Ala Cys Cys Ser Thr Gln Met Pro Trp Ser Thr Cys 
                85                  90                  


<210>  9236
<211>  429
<212>  PRT
<213>  Homo Sapiens

<400>  9236

Met Ala Leu Arg Leu Leu Lys Leu Ala Ala Thr Ser Ala Ser Ala Arg 
1               5                   10                  15      


Val Val Ala Ala Gly Ala Gln Arg Val Arg Gly Ile His Ser Ser Val 
            20                  25                  30          


Gln Cys Lys Leu Arg Tyr Gly Met Trp His Phe Leu Leu Gly Asp Lys 
        35                  40                  45              


Ala Ser Lys Arg Leu Thr Glu Arg Ser Arg Val Ile Thr Val Asp Gly 
    50                  55                  60                  


Asn Ile Cys Thr Gly Lys Gly Lys Leu Ala Lys Glu Ile Ala Glu Lys 
65                  70                  75                  80  


Leu Gly Phe Lys His Phe Pro Glu Ala Gly Ile His Tyr Pro Asp Ser 
                85                  90                  95      


Thr Thr Gly Asp Gly Lys Pro Leu Ala Thr Asp Tyr Asn Gly Asn Cys 
            100                 105                 110         


Ser Leu Glu Lys Phe Tyr Asp Asp Pro Arg Ser Asn Asp Gly Asn Ser 
        115                 120                 125             


Tyr Arg Leu Gln Ser Trp Leu Tyr Ser Ser Arg Leu Leu Gln Tyr Ser 
    130                 135                 140                 


Asp Ala Leu Glu His Leu Leu Thr Thr Gly Gln Gly Val Val Leu Glu 
145                 150                 155                 160 


Arg Ser Ile Phe Ser Asp Phe Val Phe Leu Glu Ala Met Tyr Asn Gln 
                165                 170                 175     


Gly Phe Ile Arg Lys Gln Cys Glu Ser Ala Leu Gln Thr His Phe Trp 
            180                 185                 190         


Thr Gly Val Ala Gly Ala Ser Gly Lys Leu Glu Ser Gly Ser Ser Glu 
        195                 200                 205             


Glu Val Leu Leu Ile Asn Glu Arg Gly Gly Arg Ser Lys Pro Gly Val 
    210                 215                 220                 


Asp His Tyr Asn Glu Val Lys Ser Val Thr Ile Cys Asp Tyr Leu Pro 
225                 230                 235                 240 


Pro His Leu Val Ile Tyr Ile Asp Val Pro Val Pro Glu Pro His Glu 
                245                 250                 255     


Met Lys Ile Thr Ser Ala Tyr Leu Gln Asp Ile Glu Asn Ala Tyr Lys 
            260                 265                 270         


Lys Thr Phe Leu Pro Glu Met Ser Glu Lys Cys Glu Val Leu Gln Tyr 
        275                 280                 285             


Ser Ala Arg Glu Ala Gln Asp Ser Lys Lys Val Val Glu Asp Ile Glu 
    290                 295                 300                 


Tyr Leu Lys Phe Asp Lys Gly Pro Trp Leu Lys Gln Asp Asn Arg Thr 
305                 310                 315                 320 


Leu Tyr His Leu Arg Leu Leu Val Gln Asp Lys Phe Glu Val Leu Asn 
                325                 330                 335     


Tyr Thr Ser Ile Pro Ile Phe Leu Pro Glu Val Thr Ile Gly Ala His 
            340                 345                 350         


Gln Thr Asp Arg Val Leu His Gln Phe Arg Glu Arg Leu Asp Trp Thr 
        355                 360                 365             


Val Cys Phe Gly Glu Glu Ser Thr Glu Val Lys His Gln Gly His Leu 
    370                 375                 380                 


Leu Ser Val Gln Pro Gly Thr Val Ala Leu Thr Val Gly Ser Trp Leu 
385                 390                 395                 400 


Arg Ser Cys Leu Leu Gly Leu His Trp Lys Leu Leu Phe Leu Phe Pro 
                405                 410                 415     


Glu Ser Pro Met His Thr Thr Ala Phe Met Phe Leu Cys 
            420                 425                 


<210>  9237
<211>  201
<212>  PRT
<213>  Homo Sapiens

<400>  9237

Met Ala Leu Arg Leu Leu Lys Leu Ala Ala Thr Ser Ala Ser Ala Arg 
1               5                   10                  15      


Val Val Ala Ala Gly Ala Gln Arg Val Arg Gly Ile His Ser Ser Val 
            20                  25                  30          


Gln Cys Lys Leu Arg Tyr Gly Met Trp His Phe Leu Leu Gly Asp Lys 
        35                  40                  45              


Ala Ser Lys Arg Leu Thr Glu Arg Ser Arg Val Ile Thr Val Asp Gly 
    50                  55                  60                  


Asn Ile Cys Thr Gly Lys Gly Lys Leu Ala Lys Glu Ile Ala Glu Lys 
65                  70                  75                  80  


Leu Gly Phe Lys His Phe Pro Glu Ala Gly Ile His Tyr Pro Asp Ser 
                85                  90                  95      


Thr Thr Gly Asp Gly Lys Pro Leu Ala Thr Asp Tyr Asn Gly Asn Cys 
            100                 105                 110         


Ser Leu Glu Lys Phe Tyr Asp Asp Pro Arg Ser Asn Asp Gly Asn Ser 
        115                 120                 125             


Tyr Arg Leu Gln Ser Trp Leu Tyr Ser Ser Arg Leu Leu Gln Tyr Ser 
    130                 135                 140                 


Asp Ala Leu Glu His Leu Leu Thr Thr Gly Gln Gly Val Val Leu Glu 
145                 150                 155                 160 


Arg Ser Ile Phe Ser Asp Phe Val Phe Leu Glu Ala Met Tyr Asn Gln 
                165                 170                 175     


Gly Phe Ile Arg Lys Gln Cys Glu Ser Ala Leu Gln Thr His Phe Trp 
            180                 185                 190         


Val Cys Gly Ala Thr Leu Gln Gly Leu 
        195                 200     


<210>  9238
<211>  355
<212>  PRT
<213>  Homo Sapiens

<400>  9238

Met Ala Leu Arg Leu Leu Lys Leu Ala Ala Thr Ser Ala Ser Ala Arg 
1               5                   10                  15      


Val Val Ala Ala Gly Ala Gln Arg Val Arg Gly Ile His Ser Ser Val 
            20                  25                  30          


Gln Cys Lys Leu Arg Tyr Gly Met Trp His Phe Leu Leu Gly Asp Lys 
        35                  40                  45              


Ala Ser Lys Arg Leu Thr Glu Arg Ser Arg Val Ile Thr Val Asp Gly 
    50                  55                  60                  


Asn Ile Cys Thr Gly Lys Gly Lys Leu Ala Lys Glu Ile Ala Glu Lys 
65                  70                  75                  80  


Leu Gly Phe Lys His Phe Pro Glu Ala Gly Ile His Tyr Pro Asp Ser 
                85                  90                  95      


Thr Thr Gly Asp Gly Lys Pro Leu Ala Thr Asp Tyr Asn Gly Asn Cys 
            100                 105                 110         


Ser Leu Glu Lys Phe Tyr Asp Asp Pro Arg Ser Asn Asp Gly Asn Ser 
        115                 120                 125             


Tyr Arg Leu Gln Ser Trp Leu Tyr Ser Ser Arg Leu Leu Gln Tyr Ser 
    130                 135                 140                 


Asp Ala Leu Glu His Leu Leu Thr Thr Gly Gln Gly Val Val Leu Glu 
145                 150                 155                 160 


Arg Ser Ile Phe Ser Asp Phe Val Phe Leu Glu Ala Met Tyr Asn Gln 
                165                 170                 175     


Gly Phe Ile Arg Lys Gln Cys Val Asp His Tyr Asn Glu Val Lys Ser 
            180                 185                 190         


Val Thr Ile Cys Asp Tyr Leu Pro Pro His Leu Val Ile Tyr Ile Asp 
        195                 200                 205             


Val Pro Val Pro Glu Val Gln Arg Arg Ile Gln Lys Lys Gly Asp Pro 
    210                 215                 220                 


His Glu Met Lys Ile Thr Ser Ala Tyr Leu Gln Asp Ile Glu Asn Ala 
225                 230                 235                 240 


Tyr Lys Lys Thr Phe Leu Pro Glu Met Ser Glu Lys Cys Glu Val Leu 
                245                 250                 255     


Gln Tyr Ser Ala Arg Glu Ala Gln Asp Ser Lys Lys Val Val Glu Asp 
            260                 265                 270         


Ile Glu Tyr Leu Lys Phe Asp Lys Gly Pro Trp Leu Lys Gln Asp Asn 
        275                 280                 285             


Arg Thr Leu Tyr His Leu Arg Leu Leu Val Gln Asp Lys Phe Glu Val 
    290                 295                 300                 


Leu Asn Tyr Thr Ser Ile Pro Ile Phe Leu Pro Glu Val Thr Ile Gly 
305                 310                 315                 320 


Ala His Gln Thr Asp Arg Val Leu His Gln Phe Arg Glu Leu Pro Gly 
                325                 330                 335     


Arg Lys Tyr Ser Pro Gly Tyr Asn Thr Glu Val Gly Asp Lys Trp Ile 
            340                 345                 350         


Trp Leu Lys 
        355 


<210>  9239
<211>  390
<212>  PRT
<213>  Homo Sapiens

<400>  9239

Met Ala Leu Arg Leu Leu Lys Leu Ala Ala Thr Ser Ala Ser Ala Arg 
1               5                   10                  15      


Val Val Ala Ala Gly Ala Gln Arg Val Arg Gly Ile His Ser Ser Val 
            20                  25                  30          


Gln Cys Lys Leu Arg Tyr Gly Met Trp His Phe Leu Leu Gly Asp Lys 
        35                  40                  45              


Ala Ser Lys Arg Leu Thr Glu Arg Ser Arg Val Ile Thr Val Asp Gly 
    50                  55                  60                  


Asn Ile Cys Thr Gly Lys Gly Lys Leu Ala Lys Glu Ile Ala Glu Lys 
65                  70                  75                  80  


Leu Gly Phe Lys His Phe Pro Glu Ala Gly Ile His Tyr Pro Asp Ser 
                85                  90                  95      


Thr Thr Gly Asp Gly Lys Pro Leu Ala Thr Asp Tyr Asn Gly Asn Cys 
            100                 105                 110         


Ser Leu Glu Lys Phe Tyr Asp Asp Pro Arg Ser Asn Asp Gly Asn Ser 
        115                 120                 125             


Tyr Arg Leu Gln Ser Trp Leu Tyr Ser Ser Arg Leu Leu Gln Tyr Ser 
    130                 135                 140                 


Asp Ala Leu Glu His Leu Leu Thr Thr Gly Gln Gly Val Val Leu Glu 
145                 150                 155                 160 


Arg Ser Ile Phe Ser Asp Phe Val Phe Leu Glu Ala Met Tyr Asn Gln 
                165                 170                 175     


Gly Phe Ile Arg Lys Gln Cys Val Asp His Tyr Asn Glu Val Lys Ser 
            180                 185                 190         


Val Thr Ile Cys Asp Tyr Leu Pro Pro His Leu Val Ile Tyr Ile Asp 
        195                 200                 205             


Val Pro Val Pro Glu Val Gln Arg Arg Ile Gln Lys Lys Gly Asp Pro 
    210                 215                 220                 


His Glu Met Lys Ile Thr Ser Ala Tyr Leu Gln Asp Ile Glu Asn Ala 
225                 230                 235                 240 


Tyr Lys Lys Thr Phe Leu Pro Glu Met Ser Glu Lys Cys Glu Val Leu 
                245                 250                 255     


Gln Tyr Ser Ala Arg Glu Ala Gln Asp Ser Lys Lys Val Val Glu Asp 
            260                 265                 270         


Ile Glu Tyr Leu Lys Phe Asp Lys Gly Pro Trp Leu Lys Gln Asp Asn 
        275                 280                 285             


Arg Thr Leu Tyr His Leu Arg Leu Leu Val Gln Asp Lys Phe Glu Val 
    290                 295                 300                 


Leu Asn Tyr Thr Ser Ile Pro Ile Phe Leu Pro Glu Val Thr Ile Gly 
305                 310                 315                 320 


Ala His Gln Thr Asp Arg Val Leu His Gln Phe Arg Glu Leu Gly Ile 
                325                 330                 335     


Pro Tyr Pro Gln Arg Ala Val Gln Ser Thr Arg Glu Gly Pro Glu Val 
            340                 345                 350         


Leu Leu Thr Gly Leu Trp Arg Trp Glu Asp Leu Leu Ile Gly Leu Gln 
        355                 360                 365             


Leu Pro Gly Arg Lys Tyr Ser Pro Gly Tyr Asn Thr Glu Val Gly Asp 
    370                 375                 380                 


Lys Trp Ile Trp Leu Lys 
385                 390 


<210>  9240
<211>  245
<212>  PRT
<213>  Homo Sapiens

<400>  9240

Met Ala Leu Arg Leu Leu Lys Leu Ala Ala Thr Ser Ala Ser Ala Arg 
1               5                   10                  15      


Val Val Ala Ala Gly Ala Gln Arg Val Arg Gly Ile His Ser Ser Val 
            20                  25                  30          


Gln Cys Lys Leu Arg Tyr Gly Met Trp His Phe Leu Leu Gly Asp Lys 
        35                  40                  45              


Ala Ser Lys Arg Leu Thr Glu Arg Ser Arg Val Ile Thr Val Asp Gly 
    50                  55                  60                  


Asn Ile Cys Thr Gly Lys Gly Lys Leu Ala Lys Glu Ile Ala Glu Lys 
65                  70                  75                  80  


Leu Gly Phe Lys His Phe Pro Glu Ala Gly Ile His Tyr Pro Asp Ser 
                85                  90                  95      


Thr Thr Gly Asp Gly Lys Pro Leu Ala Thr Asp Tyr Asn Gly Asn Cys 
            100                 105                 110         


Ser Leu Glu Lys Phe Tyr Asp Asp Pro Arg Ser Asn Asp Gly Asn Ser 
        115                 120                 125             


Tyr Arg Leu Gln Ser Trp Leu Tyr Ser Ser Arg Leu Leu Gln Tyr Ser 
    130                 135                 140                 


Asp Ala Leu Glu His Leu Leu Thr Thr Gly Gln Gly Val Val Leu Glu 
145                 150                 155                 160 


Arg Ser Ile Phe Ser Asp Phe Val Phe Leu Glu Ala Met Tyr Asn Gln 
                165                 170                 175     


Gly Phe Ile Arg Lys Gln Leu Lys Asn Val Arg Phe Tyr Asn Ile Leu 
            180                 185                 190         


Gln Gly Lys Leu Lys Ile Gln Lys Arg Val Gln Asp Lys Phe Glu Val 
        195                 200                 205             


Leu Asn Tyr Thr Ser Ile Pro Ile Phe Leu Pro Glu Val Thr Ile Gly 
    210                 215                 220                 


Ala His Gln Thr Asp Arg Val Leu His Gln Phe Arg Glu Leu Pro Gly 
225                 230                 235                 240 


Arg Lys Tyr Ser Pro 
                245 


<210>  9241
<211>  355
<212>  PRT
<213>  Homo Sapiens

<400>  9241

Met Ala Leu Arg Leu Leu Lys Leu Ala Ala Thr Ser Ala Ser Ala Arg 
1               5                   10                  15      


Val Val Ala Arg Ala Pro Ser Ala Trp Arg Gly Ile His Ser Ser Val 
            20                  25                  30          


Gln Cys Lys Leu Arg Tyr Gly Met Trp His Phe Leu Leu Gly Asp Lys 
        35                  40                  45              


Ala Ser Lys Arg Leu Thr Glu Arg Ser Arg Val Ile Thr Val Asp Gly 
    50                  55                  60                  


Asn Ile Cys Thr Gly Lys Gly Lys Leu Ala Lys Glu Ile Ala Glu Lys 
65                  70                  75                  80  


Leu Gly Phe Lys His Phe Pro Glu Ala Gly Ile His Tyr Pro Asp Ser 
                85                  90                  95      


Thr Thr Gly Asp Gly Lys Pro Leu Ala Thr Asp Tyr Asn Gly Asn Cys 
            100                 105                 110         


Ser Leu Glu Lys Phe Tyr Asp Asp Pro Arg Ser Asn Asp Gly Asn Ser 
        115                 120                 125             


Tyr Arg Leu Gln Ser Trp Leu Tyr Ser Ser Arg Leu Leu Gln Tyr Ser 
    130                 135                 140                 


Asp Ala Leu Glu His Leu Leu Thr Thr Gly Gln Gly Val Val Leu Glu 
145                 150                 155                 160 


Arg Ser Ile Phe Ser Asp Phe Val Phe Leu Glu Ala Met Tyr Asn Gln 
                165                 170                 175     


Gly Phe Ile Arg Lys Gln Cys Val Asp His Tyr Asn Glu Val Lys Ser 
            180                 185                 190         


Val Thr Ile Cys Asp Tyr Leu Pro Pro His Leu Val Ile Tyr Ile Asp 
        195                 200                 205             


Val Pro Val Pro Glu Val Gln Arg Arg Ile Gln Lys Lys Gly Asp Pro 
    210                 215                 220                 


His Glu Met Lys Ile Thr Ser Ala Tyr Leu Gln Asp Ile Glu Asn Ala 
225                 230                 235                 240 


Tyr Lys Lys Thr Phe Leu Pro Glu Met Ser Glu Lys Cys Glu Val Leu 
                245                 250                 255     


Gln Tyr Ser Ala Arg Glu Ala Gln Asp Ser Lys Lys Val Val Glu Asp 
            260                 265                 270         


Ile Glu Tyr Leu Lys Phe Asp Lys Gly Pro Trp Leu Lys Gln Asp Asn 
        275                 280                 285             


Arg Thr Leu Tyr His Leu Arg Leu Leu Val Gln Asp Lys Phe Glu Val 
    290                 295                 300                 


Leu Asn Tyr Thr Ser Ile Pro Ile Phe Leu Pro Glu Val Thr Ile Gly 
305                 310                 315                 320 


Ala His Gln Thr Asp Arg Val Leu His Gln Phe Arg Glu Leu Pro Gly 
                325                 330                 335     


Arg Lys Tyr Ser Pro Gly Tyr Asn Thr Glu Val Gly Asp Lys Trp Ile 
            340                 345                 350         


Trp Leu Lys 
        355 


<210>  9242
<211>  133
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9242

Xaa Ser Ala Tyr Leu Gln Asp Ile Glu Asn Ala Tyr Lys Lys Thr Phe 
1               5                   10                  15      


Leu Pro Glu Met Ser Glu Lys Cys Glu Val Leu Gln Tyr Ser Ala Arg 
            20                  25                  30          


Glu Ala Gln Asp Ser Lys Lys Val Val Glu Asp Ile Glu Tyr Leu Lys 
        35                  40                  45              


Phe Asp Lys Gly Pro Trp Leu Lys Gln Asp Asn Arg Thr Leu Tyr His 
    50                  55                  60                  


Leu Arg Leu Leu Val Gln Asp Lys Phe Glu Val Leu Asn Tyr Thr Ser 
65                  70                  75                  80  


Ile Pro Ile Phe Leu Pro Glu Val Thr Ile Gly Ala His Gln Thr Asp 
                85                  90                  95      


Arg Val Leu His Gln Phe Arg Glu Val Phe Gln Glu Ser Glu Ala Lys 
            100                 105                 110         


Arg Leu Asp Val Glu Glu Val Cys Trp Lys Lys Thr Pro Leu Lys Asp 
        115                 120                 125             


Arg Gly Glu Glu Val 
    130             


<210>  9243
<211>  100
<212>  PRT
<213>  Homo Sapiens

<400>  9243

Gly Phe Arg Leu Leu Arg Trp Gln Leu Cys Leu Ala Gly Pro Leu Ala 
1               5                   10                  15      


Leu Ala Ser Asp Leu Gly Ala Ser Ser Leu Val Ala Phe Arg Arg Leu 
            20                  25                  30          


Leu Gly Asn Ser Ile Phe Pro Ala Pro Val Arg His Ser Gly Asp His 
        35                  40                  45              


Gly Lys Arg Leu Phe Val Ile Arg Pro Ser Arg Phe Tyr Asp Arg Arg 
    50                  55                  60                  


Phe Leu Lys Leu Leu Arg Phe Tyr Ile Ala Leu Thr Gly Ile Pro Val 
65                  70                  75                  80  


Ala Ile Phe Ile Thr Leu Val Asn Val Phe Ile Ala Ser His Ile Lys 
                85                  90                  95      


Met Asp Cys Pro 
            100 


<210>  9244
<211>  56
<212>  PRT
<213>  Homo Sapiens

<400>  9244

Ile Pro Val Ala Ile Phe Ile Thr Leu Val Asn Val Phe Ile Gly Gln 
1               5                   10                  15      


Ala Glu Leu Ala Glu Ile Pro Glu Gly Tyr Val Pro Glu His Trp Glu 
            20                  25                  30          


Tyr Tyr Lys Gly Lys Gly Ala Gly Ser Ala Lys Ile Asp Ala Cys Glu 
        35                  40                  45              


Arg Arg Trp Thr Leu Val Leu Leu 
    50                  55      


<210>  9245
<211>  177
<212>  PRT
<213>  Homo Sapiens

<400>  9245

Met Ala Ala Met Ser Leu Leu Arg Arg Val Ser Val Thr Ala Val Ala 
1               5                   10                  15      


Ala Leu Ser Gly Arg Pro Leu Gly Thr Arg Leu Gly Phe Gly Gly Phe 
            20                  25                  30          


Leu Thr Arg Gly Phe Pro Lys Ala Ala Ala Pro Gly Asn His His Ser 
        35                  40                  45              


Ala Val Phe Met Ile Leu Thr Thr Leu Phe Leu Ile Phe Tyr Ile Ala 
    50                  55                  60                  


Leu Thr Gly Ile Pro Val Ala Ile Phe Ile Thr Leu Val Asn Val Phe 
65                  70                  75                  80  


Ile Gly Gln Ala Glu Leu Ala Glu Ile Pro Glu Gly Tyr Val Pro Glu 
                85                  90                  95      


His Trp Glu Tyr Tyr Lys His Pro Ile Ser Arg Trp Ile Ala Arg Asn 
            100                 105                 110         


Phe Tyr Asp Ser Pro Glu Lys Ile Tyr Glu Arg Thr Met Ala Val Leu 
        115                 120                 125             


Gln Ile Glu Ala Glu Lys Ala Glu Leu Arg Val Lys Glu Leu Glu Val 
    130                 135                 140                 


Arg Lys Leu Met His Val Arg Gly Asp Gly Pro Trp Tyr Tyr Tyr Glu 
145                 150                 155                 160 


Thr Ile Asp Lys Glu Leu Ile Asp His Ser Pro Lys Ala Thr Pro Asp 
                165                 170                 175     


Asn 
    


<210>  9246
<211>  135
<212>  PRT
<213>  Homo Sapiens

<400>  9246

Met Ala Ala Met Ser Leu Leu Arg Arg Val Ser Val Thr Ala Val Ala 
1               5                   10                  15      


Ala Leu Ser Gly Arg Pro Leu Gly Thr Arg Leu Gly Phe Gly Gly Phe 
            20                  25                  30          


Leu Thr Arg Gly Phe Pro Lys Ala Ala Ala Pro Val Arg His Ser Gly 
        35                  40                  45              


Asp His Gly Lys Arg Leu Phe Val Ile Arg Pro Ser Arg Phe Tyr Asp 
    50                  55                  60                  


Arg Arg Phe Leu Lys Leu Leu Arg Phe Tyr Ile Ala Leu Thr Gly Ile 
65                  70                  75                  80  


Pro Val Ala Ile Phe Ile Thr Leu Val Asn Val Phe Ile Gly Gln Ala 
                85                  90                  95      


Glu Leu Ala Glu Ile Pro Glu Gly Tyr Val Pro Glu His Trp Glu Tyr 
            100                 105                 110         


Tyr Lys Gly Lys Gly Ala Gly Ser Ala Lys Ile Asp Ala Cys Glu Arg 
        115                 120                 125             


Arg Trp Thr Leu Val Leu Leu 
    130                 135 


<210>  9247
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  9247

Met Ala Ala Met Ser Leu Leu Arg Arg Val Ser Val Thr Ala Val Ala 
1               5                   10                  15      


Ala Leu Ser Gly Arg Pro Leu Gly Thr Arg Leu Gly Phe Gly Gly Phe 
            20                  25                  30          


Leu Thr Arg Gly Phe Pro Lys Ala Ala Ala Pro Val Arg His Ser Gly 
        35                  40                  45              


Asp His Gly Lys Arg Leu Phe Val Ile Arg Pro Ser Arg Phe Tyr Asp 
    50                  55                  60                  


Arg Arg Phe Leu Lys Leu Leu Arg Phe Tyr Ile Ala Leu Thr Gly Ile 
65                  70                  75                  80  


Pro Val Ala Ile Phe Ile Thr Leu Val Asn Val Phe Ile Gly Gln Ala 
                85                  90                  95      


Glu Leu Ala Glu Ile Pro Glu Gly Tyr Val Pro Glu His Trp Glu Tyr 
            100                 105                 110         


Tyr Lys His Pro Ile Ser Arg Trp Ile Ala Arg Asn Phe Tyr Asp Ser 
        115                 120                 125             


Pro Glu Lys Ile Tyr Glu Arg Thr Met Ala Val Leu Gln Ile Glu Ala 
    130                 135                 140                 


Glu Lys Ala Glu Leu Arg Val Lys Glu Leu Glu Val Arg Lys Leu Met 
145                 150                 155                 160 


His Val Arg Gly Asp Gly Pro Trp Tyr Tyr Tyr Glu Thr Ile Asp Lys 
                165                 170                 175     


Glu Leu Ile Asp His Ser Pro Lys Ala Thr Pro Asp Asn 
            180                 185                 


<210>  9248
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  9248

Met Ala Ala Met Ser Leu Leu Arg Arg Val Ser Val Thr Ala Val Ala 
1               5                   10                  15      


Ala Leu Ser Gly Arg Pro Leu Gly Thr Arg Leu Gly Phe Gly Gly Phe 
            20                  25                  30          


Leu Thr Arg Gly Phe Pro Lys Ala Ala Glu Ile Leu His Cys Ile Asp 
        35                  40                  45              


Trp Asp Ser Ser Ser Asn Phe His Asn Ser Gly Glu Cys Ile His Trp 
    50                  55                  60                  


Ser Ser 
65      


<210>  9249
<211>  42
<212>  PRT
<213>  Homo Sapiens

<400>  9249

Met Ala Ala Met Ser Leu Leu Arg Arg Val Ser Val Thr Ala Val Ala 
1               5                   10                  15      


Ala Leu Ser Gly Arg Pro Leu Gly Thr Arg Leu Gly Phe Gly Gly Phe 
            20                  25                  30          


Leu Thr Arg Gly Phe Pro Lys Ala Ala Gly 
        35                  40          


<210>  9250
<211>  137
<212>  PRT
<213>  Homo Sapiens

<400>  9250

Met Ala Ala Met Ser Leu Leu Arg Arg Val Ser Val Thr Ala Val Ala 
1               5                   10                  15      


Ala Leu Ser Gly Arg Pro Leu Gly Thr Arg Leu Gly Phe Gly Gly Phe 
            20                  25                  30          


Leu Thr Arg Gly Phe Pro Lys Ala Ala Gly Gln Ala Glu Leu Ala Glu 
        35                  40                  45              


Ile Pro Glu Gly Tyr Val Pro Glu His Trp Glu Tyr Tyr Lys His Pro 
    50                  55                  60                  


Ile Ser Arg Trp Ile Ala Arg Asn Phe Tyr Asp Ser Pro Glu Lys Ile 
65                  70                  75                  80  


Tyr Glu Arg Thr Met Ala Val Leu Gln Ile Glu Ala Glu Lys Ala Glu 
                85                  90                  95      


Leu Arg Val Lys Glu Leu Glu Val Arg Lys Leu Met His Val Arg Gly 
            100                 105                 110         


Asp Gly Pro Trp Tyr Tyr Tyr Glu Thr Ile Asp Lys Glu Leu Ile Asp 
        115                 120                 125             


His Ser Pro Lys Ala Thr Pro Asp Asn 
    130                 135         


<210>  9251
<211>  206
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9251

Xaa Ser Leu Leu Arg Arg Val Ser Val Thr Ala Val Ala Ala Leu Ser 
1               5                   10                  15      


Gly Arg Pro Leu Gly Thr Arg Leu Gly Phe Gly Gly Phe Leu Thr Arg 
            20                  25                  30          


Gly Phe Pro Lys Ala Ala Ala Pro Val Arg His Ser Gly Asp His Gly 
        35                  40                  45              


Lys Arg Leu Phe Val Ile Arg Pro Ser Arg Phe Tyr Asp Arg Arg Phe 
    50                  55                  60                  


Leu Lys Leu Leu Ala Leu Tyr Glu Gln Ser Arg Gly Leu Glu Asn Gly 
65                  70                  75                  80  


Arg Leu Ser Gly Pro Ser Ala Thr Arg Phe Tyr Ile Ala Leu Thr Gly 
                85                  90                  95      


Ile Pro Val Ala Ile Phe Ile Thr Leu Val Asn Val Phe Ile Gly Gln 
            100                 105                 110         


Ala Glu Leu Ala Glu Ile Pro Glu Gly Tyr Val Pro Glu His Trp Glu 
        115                 120                 125             


Tyr Tyr Lys His Pro Ile Ser Arg Trp Ile Ala Arg Asn Phe Tyr Asp 
    130                 135                 140                 


Ser Pro Glu Lys Ile Tyr Glu Arg Thr Met Ala Val Leu Gln Ile Glu 
145                 150                 155                 160 


Ala Glu Lys Ala Glu Leu Arg Val Lys Glu Leu Glu Val Arg Lys Leu 
                165                 170                 175     


Met His Val Arg Gly Asp Gly Pro Trp Tyr Tyr Tyr Glu Thr Ile Asp 
            180                 185                 190         


Lys Glu Leu Ile Asp His Ser Pro Lys Ala Thr Pro Asp Asn 
        195                 200                 205     


<210>  9252
<211>  40
<212>  PRT
<213>  Homo Sapiens

<400>  9252

Leu Thr Thr Pro Met Leu Leu Arg Ala Leu Ala Gln Ala Ala Arg Ala 
1               5                   10                  15      


Gly Pro Pro Gly Gly Arg Ser Leu His Ser Ser Ala Val Ala Ala Thr 
            20                  25                  30          


Tyr Ser Glu Tyr Leu Gly Gly Leu 
        35                  40  


<210>  9253
<211>  110
<212>  PRT
<213>  Homo Sapiens

<400>  9253

Met Arg Cys Leu Thr Thr Pro Met Leu Leu Arg Ala Leu Ala Gln Ala 
1               5                   10                  15      


Ala Arg Ala Gly Pro Pro Gly Gly Arg Ser Leu His Ser Ser Ala Val 
            20                  25                  30          


Ala Ala Thr Tyr Lys Tyr Val Asn Met Gln Asp Pro Glu Met Asp Met 
        35                  40                  45              


Lys Ser Val Thr Asp Arg Ala Ala Arg Thr Leu Leu Trp Thr Glu Leu 
    50                  55                  60                  


Phe Arg Gly Leu Gly Met Thr Leu Ser Tyr Leu Phe Arg Glu Pro Ala 
65                  70                  75                  80  


Thr Ile Asn Tyr Pro Phe Glu Lys Gly Pro Leu Ser Pro Arg Phe Arg 
                85                  90                  95      


Gly Glu His Ala Leu Arg Arg Tyr Pro Ser Gly Glu Glu Arg 
            100                 105                 110 


<210>  9254
<211>  124
<212>  PRT
<213>  Homo Sapiens

<400>  9254

Met Arg Cys Leu Thr Thr Pro Met Leu Leu Arg Ala Leu Ala Gln Ala 
1               5                   10                  15      


Ala Arg Ala Gly Pro Pro Gly Gly Arg Ser Leu His Ser Ser Ala Val 
            20                  25                  30          


Ala Ala Thr Tyr Lys Tyr Val Asn Met Gln Asp Pro Glu Met Asp Met 
        35                  40                  45              


Lys Ser Val Thr Asp Arg Ala Ala Arg Thr Leu Leu Trp Thr Glu Leu 
    50                  55                  60                  


Phe Arg Gly Leu Gly Met Thr Leu Ser Tyr Leu Phe Arg Glu Pro Ala 
65                  70                  75                  80  


Thr Ile Asn Tyr Pro Phe Glu Lys Gly Pro Leu Ser Pro Arg Phe Arg 
                85                  90                  95      


Gly Glu His Ala Leu Arg Arg Tyr Pro Ser Gly Glu Glu Arg Cys Ile 
            100                 105                 110         


Ala Cys Lys Leu Cys Glu Ala Ile Cys Pro Ala Gln 
        115                 120                 


<210>  9255
<211>  184
<212>  PRT
<213>  Homo Sapiens

<400>  9255

Met Arg Cys Leu Thr Thr Pro Met Leu Leu Arg Ala Leu Ala Gln Ala 
1               5                   10                  15      


Ala Arg Ala Gly Pro Pro Gly Gly Arg Ser Leu His Ser Ser Ala Val 
            20                  25                  30          


Ala Ala Thr Tyr Lys Tyr Val Asn Met Gln Asp Pro Glu Met Asp Met 
        35                  40                  45              


Lys Ser Val Thr Asp Arg Ala Ala Arg Thr Leu Leu Trp Thr Glu Leu 
    50                  55                  60                  


Phe Arg Gly Leu Gly Met Thr Leu Ser Tyr Leu Phe Arg Glu Pro Ala 
65                  70                  75                  80  


Thr Ile Asn Tyr Pro Phe Glu Lys Gly Pro Leu Ser Pro Arg Phe Arg 
                85                  90                  95      


Gly Glu His Ala Leu Arg Arg Tyr Pro Ser Gly Glu Glu Arg Cys Ile 
            100                 105                 110         


Ala Cys Lys Leu Cys Glu Ala Ile Cys Pro Ala Gln Ala Ile Thr Ile 
        115                 120                 125             


Glu Ala Glu Pro Arg Ala Asp Gly Ser Arg Arg Thr Thr Arg Tyr Asp 
    130                 135                 140                 


Ile Asp Met Thr Lys Cys Ile Tyr Cys Gly Phe Cys Gln Glu Ala Cys 
145                 150                 155                 160 


Pro Val Asp Ala Ile Val Glu Gly Pro Asn Phe Glu Phe Ser Thr Glu 
                165                 170                 175     


Thr His Glu Glu Leu Leu Tyr Asn 
            180                 


<210>  9256
<211>  210
<212>  PRT
<213>  Homo Sapiens

<400>  9256

Met Arg Cys Leu Thr Thr Pro Met Leu Leu Arg Ala Leu Ala Gln Ala 
1               5                   10                  15      


Ala Arg Ala Gly Pro Pro Gly Gly Arg Ser Leu His Ser Ser Ala Val 
            20                  25                  30          


Ala Ala Thr Tyr Lys Tyr Val Asn Met Gln Asp Pro Glu Met Asp Met 
        35                  40                  45              


Lys Ser Val Thr Asp Arg Ala Ala Arg Thr Leu Leu Trp Thr Glu Leu 
    50                  55                  60                  


Phe Arg Gly Leu Gly Met Thr Leu Ser Tyr Leu Phe Arg Glu Pro Ala 
65                  70                  75                  80  


Thr Ile Asn Tyr Pro Phe Glu Lys Gly Pro Leu Ser Pro Arg Phe Arg 
                85                  90                  95      


Gly Glu His Ala Leu Arg Arg Tyr Pro Ser Gly Glu Glu Arg Cys Ile 
            100                 105                 110         


Ala Cys Lys Leu Cys Glu Ala Ile Cys Pro Ala Gln Ala Ile Thr Ile 
        115                 120                 125             


Glu Ala Glu Pro Arg Ala Asp Gly Ser Arg Arg Thr Thr Arg Tyr Asp 
    130                 135                 140                 


Ile Asp Met Thr Lys Cys Ile Tyr Cys Gly Phe Cys Gln Glu Ala Cys 
145                 150                 155                 160 


Pro Val Asp Ala Ile Val Glu Gly Pro Asn Phe Glu Phe Ser Thr Glu 
                165                 170                 175     


Thr His Glu Glu Leu Leu Tyr Asn Lys Glu Lys Leu Leu Asn Asn Gly 
            180                 185                 190         


Asp Lys Trp Glu Ala Glu Ile Ala Ala Asn Ile Gln Ala Asp Tyr Leu 
        195                 200                 205             


Tyr Arg 
    210 


<210>  9257
<211>  43
<212>  PRT
<213>  Homo Sapiens

<400>  9257

Met Arg Cys Leu Thr Thr Pro Met Leu Leu Arg Ala Leu Ala Gln Ala 
1               5                   10                  15      


Ala Arg Ala Gly Pro Pro Gly Gly Arg Ser Leu His Ser Ser Ala Val 
            20                  25                  30          


Ala Ala Thr Tyr Ser Glu Tyr Leu Gly Gly Leu 
        35                  40              


<210>  9258
<211>  70
<212>  PRT
<213>  Homo Sapiens

<400>  9258

Met Arg Arg Pro Leu Cys Ala Thr Gly Leu Val Arg Val Gly Asp His 
1               5                   10                  15      


Trp Glu Asp Ala Leu Pro Asp His Ala Tyr Ala Ala Ala Gly Pro Gly 
            20                  25                  30          


Pro Gly Cys Thr Cys Arg Thr Ser Trp Trp Pro Glu Pro Pro Gln Gln 
        35                  40                  45              


Cys Ser Gly Ser His Leu Gln Val Cys Glu His Ala Gly Ser Arg Asp 
    50                  55                  60                  


Gly His Glu Val Ser Asp 
65                  70  


<210>  9259
<211>  138
<212>  PRT
<213>  Homo Sapiens

<400>  9259

Met Arg Arg Pro Leu Cys Ala Thr Gly Leu Val Arg Val Gly Asp His 
1               5                   10                  15      


Trp Glu Glu Tyr Val Asn Met Gln Asp Pro Glu Met Asp Met Lys Ser 
            20                  25                  30          


Val Thr Asp Arg Ala Ala Arg Thr Leu Leu Trp Thr Glu Leu Phe Arg 
        35                  40                  45              


Gly Leu Gly Met Thr Leu Ser Tyr Leu Phe Arg Glu Pro Ala Thr Ile 
    50                  55                  60                  


Asn Tyr Pro Phe Glu Lys Gly Pro Leu Ser Pro Arg Phe Arg Gly Glu 
65                  70                  75                  80  


His Ala Leu Arg Arg Tyr Pro Ser Gly Glu Glu Arg Cys Ile Ala Cys 
                85                  90                  95      


Lys Leu Cys Glu Ala Ile Cys Pro Ala Gln Ala Ile Thr Ile Glu Ala 
            100                 105                 110         


Glu Pro Arg Ala Asp Gly Ser Arg Arg Thr Thr Arg Tyr Asp Ile Asp 
        115                 120                 125             


Met Thr Lys Cys Ile Tyr Cys Gly Phe Cys 
    130                 135             


<210>  9260
<211>  64
<212>  PRT
<213>  Homo Sapiens

<400>  9260

Met Thr Lys Cys Ile Tyr Cys Gly Phe Cys Gln Glu Ala Cys Pro Val 
1               5                   10                  15      


Asp Ala Ile Val Glu Gly Pro Asn Phe Glu Phe Ser Thr Glu Thr His 
            20                  25                  30          


Glu Glu Leu Leu Tyr Asn Lys Glu Lys Leu Leu Asn Asn Gly Asp Lys 
        35                  40                  45              


Trp Glu Ala Glu Ile Ala Ala Asn Ile Gln Ala Asp Tyr Leu Tyr Arg 
    50                  55                  60                  


<210>  9261
<211>  93
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9261

Xaa Glu Pro Ala Thr Ile Asn Tyr Pro Phe Glu Lys Gly Pro Leu Ser 
1               5                   10                  15      


Pro Arg Phe Arg Gly Glu His Ala Leu Arg Arg Tyr Pro Ser Gly Glu 
            20                  25                  30          


Glu Arg Cys Ile Ala Cys Lys Leu Cys Glu Ala Ile Cys Pro Ala Gln 
        35                  40                  45              


Gly Glu Thr Leu Arg Ala Ala Gly Ala Thr Leu Asn Lys Ala Val Asn 
    50                  55                  60                  


Ser Pro Leu Val Arg Gly Gly Ser Trp Gln Met Thr Pro Ala Ala Asp 
65                  70                  75                  80  


Lys Gln Ala Arg Gln Ala Gly His Gly Gly Ser Arg Leu 
                85                  90              


<210>  9262
<211>  127
<212>  PRT
<213>  Homo Sapiens

<400>  9262

Cys Pro Thr Thr Val Ala Asn Val Glu Thr Val Ala Val Ser Pro Thr 
1               5                   10                  15      


Ile Cys Arg Arg Gly Gly Thr Trp Phe Ala Gly Phe Gly Arg Glu Arg 
            20                  25                  30          


Asn Ser Gly Thr Lys Leu Phe Asn Ile Ser Gly His Val Asn His Pro 
        35                  40                  45              


Cys Thr Val Glu Glu Glu Met Ser Val Pro Leu Lys Glu Leu Ile Glu 
    50                  55                  60                  


Lys His Ala Gly Gly Val Thr Gly Gly Trp Asp Asn Leu Leu Ala Val 
65                  70                  75                  80  


Ile Pro Gly Gly Ser Ser Thr Pro Leu Ile Pro Lys Ser Val Cys Glu 
                85                  90                  95      


Thr Val Leu Met Asp Phe Asp Ala Leu Val Gln Ala Gln Thr Gly Leu 
            100                 105                 110         


Gly Thr Ala Ala Val Ile Val Met Asp Arg Ser Val Trp Thr Gly 
        115                 120                 125         


<210>  9263
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  9263

Glu Ala Tyr Glu Ala Gly Leu Ile Gly Lys Asn Ala Cys Gly Ser Gly 
1               5                   10                  15      


Tyr Asp Phe Asp Val Phe Val Val Arg Gly Ala Gly Ala Tyr Ile Cys 
            20                  25                  30          


Gly Glu Glu Thr Ala Leu Ile Glu Ser Ile Glu Gly Lys Gln Gly Lys 
        35                  40                  45              


Pro Arg Leu Lys Pro Pro Phe Pro Ala Asp Val Gly Val Phe Gly Cys 
    50                  55                  60                  


Pro Thr Thr Val Ala Asn Val Glu Thr Val Ala Val Ser Pro Thr Ile 
65                  70                  75                  80  


Cys Arg Arg Gly Gly Thr Trp Phe Ala Gly Phe Gly Arg Glu Arg Asn 
                85                  90                  95      


Ser Gly Thr Lys Leu Phe Asn Ile Ser Gly His Val Asn His Pro Cys 
            100                 105                 110         


Thr Val Glu Glu Glu Met Ser Val Pro Leu Lys Glu Leu Ile Glu Lys 
        115                 120                 125             


His Ala Val Cys Val 
    130             


<210>  9264
<211>  75
<212>  PRT
<213>  Homo Sapiens

<400>  9264

Met Gly Ile Pro Ser Pro Ser Ala Ala Pro Lys Lys Thr Ser Phe Gly 
1               5                   10                  15      


Ser Leu Lys Asp Glu Asp Arg Ile Phe Thr Asn Leu Tyr Gly Arg His 
            20                  25                  30          


Asp Trp Arg Leu Lys Gly Ser Leu Ser Arg Gly Asp Trp Tyr Lys Thr 
        35                  40                  45              


Lys Glu Ile Leu Leu Lys Gly Pro Asp Trp Ile Leu Gly Glu Ile Lys 
    50                  55                  60                  


Thr Ser Gly Leu Arg Gly Arg Gly Gly Ala Gly 
65                  70                  75  


<210>  9265
<211>  144
<212>  PRT
<213>  Homo Sapiens

<400>  9265

Met Lys Thr Gly Phe Ser Pro Thr Cys Thr Ala Ala Met Thr Gly Gly 
1               5                   10                  15      


Ser Leu Ser Arg Gly Asp Trp Tyr Lys Thr Lys Glu Ile Leu Leu Lys 
            20                  25                  30          


Gly Pro Asp Trp Ile Leu Gly Glu Ile Lys Thr Ser Gly Leu Arg Gly 
        35                  40                  45              


Arg Gly Gly Ala Gly Phe Pro Thr Gly Leu Lys Trp Ser Phe Met Asn 
    50                  55                  60                  


Lys Pro Ser Asp Gly Arg Pro Lys Tyr Leu Val Val Asn Ala Asp Glu 
65                  70                  75                  80  


Gly Glu Pro Gly Thr Cys Lys Asp Arg Glu Ile Leu Arg His Asp Pro 
                85                  90                  95      


His Lys Leu Leu Glu Gly Cys Leu Val Gly Gly Arg Ala Met Gly Ala 
            100                 105                 110         


Arg Ala Ala Tyr Ile Tyr Ile Arg Gly Glu Phe Tyr Asn Glu Ala Ser 
        115                 120                 125             


Asn Leu Gln Val Ala Ile Arg Glu Ala Tyr Glu Ala Gly Leu Ile Gly 
    130                 135                 140                 


<210>  9266
<211>  455
<212>  PRT
<213>  Homo Sapiens

<400>  9266

Met Leu Ala Thr Arg Arg Leu Leu Gly Trp Ser Leu Pro Ala Arg Thr 
1               5                   10                  15      


Ala Pro Lys Lys Thr Ser Phe Gly Ser Leu Lys Asp Glu Asp Arg Ile 
            20                  25                  30          


Phe Thr Asn Leu Tyr Gly Arg His Asp Trp Arg Leu Lys Gly Ser Leu 
        35                  40                  45              


Ser Arg Gly Asp Trp Tyr Lys Thr Lys Glu Ile Leu Leu Lys Gly Pro 
    50                  55                  60                  


Asp Trp Ile Leu Gly Glu Ile Lys Thr Ser Gly Leu Arg Gly Arg Gly 
65                  70                  75                  80  


Gly Ala Gly Phe Pro Thr Gly Leu Lys Trp Ser Phe Met Asn Lys Pro 
                85                  90                  95      


Ser Asp Gly Arg Pro Lys Tyr Leu Val Val Asn Ala Asp Glu Gly Glu 
            100                 105                 110         


Pro Gly Thr Cys Lys Asp Arg Glu Ile Leu Arg His Asp Pro His Lys 
        115                 120                 125             


Leu Leu Glu Gly Cys Leu Val Gly Gly Arg Ala Met Gly Ala Arg Ala 
    130                 135                 140                 


Ala Tyr Ile Tyr Ile Arg Gly Glu Phe Tyr Asn Glu Ala Ser Asn Leu 
145                 150                 155                 160 


Gln Val Ala Ile Arg Glu Ala Tyr Glu Ala Gly Leu Ile Gly Lys Asn 
                165                 170                 175     


Ala Cys Gly Ser Gly Tyr Asp Phe Asp Val Phe Val Val Arg Gly Ala 
            180                 185                 190         


Gly Ala Tyr Ile Cys Gly Glu Glu Thr Ala Leu Ile Glu Ser Ile Glu 
        195                 200                 205             


Gly Lys Gln Gly Lys Pro Arg Leu Lys Pro Pro Phe Pro Ala Asp Val 
    210                 215                 220                 


Gly Val Phe Gly Cys Pro Thr Thr Val Ala Asn Val Glu Thr Val Ala 
225                 230                 235                 240 


Val Ser Pro Thr Ile Cys Arg Arg Gly Gly Thr Trp Phe Ala Gly Phe 
                245                 250                 255     


Gly Arg Glu Arg Asn Ser Gly Thr Lys Leu Phe Asn Ile Ser Gly His 
            260                 265                 270         


Val Asn His Pro Cys Thr Val Glu Glu Glu Met Ser Val Pro Leu Lys 
        275                 280                 285             


Glu Leu Ile Glu Lys His Ala Gly Gly Val Thr Gly Gly Trp Asp Asn 
    290                 295                 300                 


Leu Leu Ala Val Ile Pro Gly Gly Ser Ser Thr Pro Leu Ile Pro Lys 
305                 310                 315                 320 


Ser Val Cys Glu Thr Val Leu Met Asp Phe Asp Ala Leu Val Gln Ala 
                325                 330                 335     


Gln Thr Gly Leu Gly Thr Ala Ala Val Ile Val Met Asp Arg Ser Thr 
            340                 345                 350         


Asp Ile Val Lys Ala Ile Ala Arg Leu Ile Glu Phe Tyr Lys His Glu 
        355                 360                 365             


Ser Cys Gly Gln Cys Thr Pro Cys Arg Glu Gly Val Asp Trp Met Asn 
    370                 375                 380                 


Lys Val Met Ala Arg Phe Val Arg Gly Asp Ala Arg Pro Ala Glu Ile 
385                 390                 395                 400 


Asp Ser Leu Trp Glu Ile Ser Lys Gln Ile Glu Gly His Thr Ile Cys 
                405                 410                 415     


Ala Leu Gly Asp Gly Ala Ala Trp Pro Val Gln Gly Leu Ile Arg His 
            420                 425                 430         


Phe Arg Pro Glu Leu Glu Glu Arg Met Gln Arg Phe Ala Gln Gln His 
        435                 440                 445             


Gln Ala Arg Gln Ala Ala Ser 
    450                 455 


<210>  9267
<211>  457
<212>  PRT
<213>  Homo Sapiens

<400>  9267

Met Leu Ala Thr Arg Arg Leu Leu Gly Trp Ser Leu Pro Ala Arg Val 
1               5                   10                  15      


Ser Thr Ala Pro Lys Lys Thr Ser Phe Gly Ser Leu Lys Asp Glu Asp 
            20                  25                  30          


Arg Ile Phe Thr Asn Leu Tyr Gly Arg His Asp Trp Arg Leu Lys Gly 
        35                  40                  45              


Ser Leu Ser Arg Gly Asp Trp Tyr Lys Thr Lys Glu Ile Leu Leu Lys 
    50                  55                  60                  


Gly Pro Asp Trp Ile Leu Gly Glu Ile Lys Thr Ser Gly Leu Arg Gly 
65                  70                  75                  80  


Arg Gly Gly Ala Gly Phe Pro Thr Gly Leu Lys Trp Ser Phe Met Asn 
                85                  90                  95      


Lys Pro Ser Asp Gly Arg Pro Lys Tyr Leu Val Val Asn Ala Asp Glu 
            100                 105                 110         


Gly Glu Pro Gly Thr Cys Lys Asp Arg Glu Ile Leu Arg His Asp Pro 
        115                 120                 125             


His Lys Leu Leu Glu Gly Cys Leu Val Gly Gly Arg Ala Met Gly Ala 
    130                 135                 140                 


Arg Ala Ala Tyr Ile Tyr Ile Arg Gly Glu Phe Tyr Asn Glu Ala Ser 
145                 150                 155                 160 


Asn Leu Gln Val Ala Ile Arg Glu Ala Tyr Glu Ala Gly Leu Ile Gly 
                165                 170                 175     


Lys Asn Ala Cys Gly Ser Gly Tyr Asp Phe Asp Val Phe Val Val Arg 
            180                 185                 190         


Gly Ala Gly Ala Tyr Ile Cys Gly Glu Glu Thr Ala Leu Ile Glu Ser 
        195                 200                 205             


Ile Glu Gly Lys Gln Gly Lys Pro Arg Leu Lys Pro Pro Phe Pro Ala 
    210                 215                 220                 


Asp Val Gly Val Phe Gly Cys Pro Thr Thr Val Ala Asn Val Glu Thr 
225                 230                 235                 240 


Val Ala Val Ser Pro Thr Ile Cys Arg Arg Gly Gly Thr Trp Phe Ala 
                245                 250                 255     


Gly Phe Gly Arg Glu Arg Asn Ser Gly Thr Lys Leu Phe Asn Ile Ser 
            260                 265                 270         


Gly His Val Asn His Pro Cys Thr Val Glu Glu Glu Met Ser Val Pro 
        275                 280                 285             


Leu Lys Glu Leu Ile Glu Lys His Ala Gly Gly Val Thr Gly Gly Trp 
    290                 295                 300                 


Asp Asn Leu Leu Ala Val Ile Pro Gly Gly Ser Ser Thr Pro Leu Ile 
305                 310                 315                 320 


Pro Lys Ser Val Cys Glu Thr Val Leu Met Asp Phe Asp Ala Leu Val 
                325                 330                 335     


Gln Ala Gln Thr Gly Leu Gly Thr Ala Ala Val Ile Val Met Asp Arg 
            340                 345                 350         


Ser Thr Asp Ile Val Lys Ala Ile Ala Arg Leu Ile Glu Phe Tyr Lys 
        355                 360                 365             


His Glu Ser Cys Gly Gln Cys Thr Pro Cys Arg Glu Gly Val Asp Trp 
    370                 375                 380                 


Met Asn Lys Val Met Ala Arg Phe Val Arg Gly Asp Ala Arg Pro Ala 
385                 390                 395                 400 


Glu Ile Asp Ser Leu Trp Glu Ile Ser Lys Gln Ile Glu Gly His Thr 
                405                 410                 415     


Ile Cys Ala Leu Gly Asp Gly Ala Ala Trp Pro Val Gln Gly Leu Ile 
            420                 425                 430         


Arg His Phe Arg Pro Glu Leu Glu Glu Arg Met Gln Arg Phe Ala Gln 
        435                 440                 445             


Gln His Gln Ala Arg Gln Ala Ala Ser 
    450                 455         


<210>  9268
<211>  178
<212>  PRT
<213>  Homo Sapiens

<400>  9268

Met Leu Ala Thr Arg Arg Leu Leu Gly Trp Ser Leu Pro Ala Arg Val 
1               5                   10                  15      


Ser Val Arg Phe Ser Gly Asp Thr Asp Glu Asp Arg Ile Phe Thr Asn 
            20                  25                  30          


Leu Tyr Gly Arg His Asp Trp Arg Leu Lys Gly Ser Leu Ser Arg Gly 
        35                  40                  45              


Asp Trp Tyr Lys Thr Lys Glu Ile Leu Leu Lys Gly Pro Asp Trp Ile 
    50                  55                  60                  


Leu Gly Glu Ile Lys Thr Ser Gly Leu Arg Gly Arg Gly Gly Ala Gly 
65                  70                  75                  80  


Phe Pro Thr Gly Leu Lys Trp Ser Phe Met Asn Lys Pro Ser Asp Gly 
                85                  90                  95      


Arg Pro Lys Tyr Leu Val Val Asn Ala Asp Glu Gly Glu Pro Gly Thr 
            100                 105                 110         


Cys Lys Asp Arg Glu Ile Leu Arg His Asp Pro His Lys Leu Leu Glu 
        115                 120                 125             


Gly Cys Leu Val Gly Gly Arg Ala Met Gly Ala Arg Ala Ala Tyr Ile 
    130                 135                 140                 


Tyr Ile Arg Gly Glu Phe Tyr Asn Glu Ala Ser Asn Leu Gln Val Ala 
145                 150                 155                 160 


Ile Arg Glu Ala Tyr Glu Ala Gly Leu Ile Gly Lys Asn Ala Cys Gly 
                165                 170                 175     


Ser Gly 
        


<210>  9269
<211>  43
<212>  PRT
<213>  Homo Sapiens

<400>  9269

Met Leu Ala Thr Arg Arg Leu Leu Gly Trp Ser Leu Pro Ala Arg Val 
1               5                   10                  15      


Ser Val Arg Phe Ser Gly Asp Thr Ser Ser Ala Trp Arg Lys Phe Cys 
            20                  25                  30          


Arg Gln His Pro Arg Lys Pro His Leu Ala Arg 
        35                  40              


<210>  9270
<211>  178
<212>  PRT
<213>  Homo Sapiens

<400>  9270

Met Leu Ala Thr Arg Arg Leu Leu Gly Trp Ser Leu Pro Ala Arg Val 
1               5                   10                  15      


Ser Val Arg Phe Ser Gly Asp Thr Thr Ala Pro Lys Lys Thr Ser Phe 
            20                  25                  30          


Gly Ser Leu Lys Asp Glu Asp Arg Ile Phe Thr Asn Leu Leu Lys Gly 
        35                  40                  45              


Ser Leu Ser Arg Gly Asp Trp Tyr Lys Thr Lys Glu Ile Leu Leu Lys 
    50                  55                  60                  


Gly Pro Asp Trp Ile Leu Gly Glu Ile Lys Thr Ser Gly Leu Arg Gly 
65                  70                  75                  80  


Arg Gly Gly Ala Gly Phe Pro Thr Gly Leu Lys Trp Ser Phe Met Asn 
                85                  90                  95      


Lys Pro Ser Asp Gly Arg Pro Lys Tyr Leu Val Val Asn Ala Asp Glu 
            100                 105                 110         


Gly Glu Pro Gly Thr Cys Lys Asp Arg Glu Ile Leu Arg His Asp Pro 
        115                 120                 125             


His Lys Leu Leu Glu Gly Cys Leu Val Gly Gly Arg Ala Met Gly Ala 
    130                 135                 140                 


Arg Ala Ala Tyr Ile Tyr Ile Arg Gly Glu Phe Tyr Asn Glu Ala Ser 
145                 150                 155                 160 


Asn Leu Gln Val Ala Ile Arg Glu Ala Tyr Glu Ala Gly Leu Ile Gly 
                165                 170                 175     


Lys Asn 
        


<210>  9271
<211>  464
<212>  PRT
<213>  Homo Sapiens

<400>  9271

Met Leu Ala Thr Arg Arg Leu Leu Gly Trp Ser Leu Pro Ala Arg Val 
1               5                   10                  15      


Ser Val Arg Phe Ser Gly Asp Thr Thr Ala Pro Lys Lys Thr Ser Phe 
            20                  25                  30          


Gly Ser Leu Lys Asp Glu Asp Arg Ile Phe Thr Asn Leu Tyr Gly Arg 
        35                  40                  45              


His Asp Trp Arg Leu Lys Gly Ser Leu Ser Arg Gly Asp Trp Tyr Lys 
    50                  55                  60                  


Thr Lys Glu Ile Leu Leu Lys Gly Pro Asp Trp Ile Leu Gly Glu Ile 
65                  70                  75                  80  


Lys Thr Ser Gly Leu Arg Gly Arg Gly Gly Ala Gly Phe Pro Thr Gly 
                85                  90                  95      


Leu Lys Trp Ser Phe Met Asn Lys Pro Ser Asp Gly Arg Pro Lys Tyr 
            100                 105                 110         


Leu Val Val Asn Ala Asp Glu Gly Glu Pro Gly Thr Cys Lys Asp Arg 
        115                 120                 125             


Glu Ile Leu Arg His Asp Pro His Lys Leu Leu Glu Gly Cys Leu Val 
    130                 135                 140                 


Gly Gly Arg Ala Met Gly Ala Arg Ala Ala Tyr Ile Tyr Ile Arg Gly 
145                 150                 155                 160 


Glu Phe Tyr Asn Glu Ala Ser Asn Leu Gln Val Ala Ile Arg Glu Ala 
                165                 170                 175     


Tyr Glu Ala Gly Leu Ile Gly Lys Asn Ala Cys Gly Ser Gly Tyr Asp 
            180                 185                 190         


Phe Asp Val Phe Val Val Arg Gly Ala Gly Ala Tyr Ile Cys Gly Glu 
        195                 200                 205             


Glu Thr Ala Leu Ile Glu Ser Ile Glu Gly Lys Gln Gly Lys Pro Arg 
    210                 215                 220                 


Leu Lys Pro Pro Phe Pro Ala Asp Val Gly Val Phe Gly Cys Pro Thr 
225                 230                 235                 240 


Thr Val Ala Asn Val Glu Thr Val Ala Val Ser Pro Thr Ile Cys Arg 
                245                 250                 255     


Arg Gly Gly Thr Trp Phe Ala Gly Phe Gly Arg Glu Arg Asn Ser Gly 
            260                 265                 270         


Thr Lys Leu Phe Asn Ile Ser Gly His Val Asn His Pro Cys Thr Val 
        275                 280                 285             


Glu Glu Glu Met Ser Val Pro Leu Lys Glu Leu Ile Glu Lys His Ala 
    290                 295                 300                 


Gly Gly Val Thr Gly Gly Trp Asp Asn Leu Leu Ala Val Ile Pro Gly 
305                 310                 315                 320 


Gly Ser Ser Thr Pro Leu Ile Pro Lys Ser Val Cys Glu Thr Val Leu 
                325                 330                 335     


Met Asp Phe Asp Ala Leu Val Gln Ala Gln Thr Gly Leu Gly Thr Ala 
            340                 345                 350         


Ala Val Ile Val Met Asp Arg Ser Thr Asp Ile Val Lys Ala Ile Ala 
        355                 360                 365             


Arg Leu Ile Glu Phe Tyr Lys His Glu Ser Cys Gly Gln Cys Thr Pro 
    370                 375                 380                 


Cys Arg Glu Gly Val Asp Trp Met Asn Lys Val Met Ala Arg Phe Val 
385                 390                 395                 400 


Arg Gly Asp Ala Arg Pro Ala Glu Ile Asp Ser Leu Trp Glu Ile Ser 
                405                 410                 415     


Lys Gln Ile Glu Gly His Thr Ile Cys Ala Leu Gly Asp Gly Ala Ala 
            420                 425                 430         


Trp Pro Val Gln Gly Leu Ile Arg His Phe Arg Pro Glu Leu Glu Glu 
        435                 440                 445             


Arg Met Gln Arg Phe Ala Gln Gln His Gln Ala Arg Gln Ala Ala Ser 
    450                 455                 460                 


<210>  9272
<211>  53
<212>  PRT
<213>  Homo Sapiens

<400>  9272

Met Asn Lys Pro Ser Asp Gly Arg Pro Lys Tyr Leu Val Val Asn Ala 
1               5                   10                  15      


Asp Glu Gly Glu Pro Gly Thr Cys Lys Asp Arg Glu Ile Leu Arg His 
            20                  25                  30          


Asp Pro His Lys Leu Leu Glu Gly Cys Leu Val Gly Gly Arg Ala Met 
        35                  40                  45              


Gly Ala Arg Ala Ala 
    50              


<210>  9273
<211>  96
<212>  PRT
<213>  Homo Sapiens

<400>  9273

Met Asn Lys Pro Ser Asp Gly Arg Pro Lys Tyr Leu Val Val Asn Ala 
1               5                   10                  15      


Asp Glu Gly Glu Pro Gly Thr Cys Lys Asp Arg Glu Ile Leu Arg His 
            20                  25                  30          


Asp Pro His Lys Leu Leu Glu Gly Cys Leu Val Gly Gly Arg Ala Met 
        35                  40                  45              


Gly Ala Arg Ala Ala Tyr Ile Tyr Ile Arg Gly Glu Phe Tyr Asn Glu 
    50                  55                  60                  


Ala Ser Asn Leu Gln Val Ala Ile Arg Glu Ala Tyr Glu Ala Gly Leu 
65                  70                  75                  80  


Ile Gly Lys Asn Ala Cys Gly Ser Gly Tyr Asp Phe Asp Val Phe Val 
                85                  90                  95      


<210>  9274
<211>  136
<212>  PRT
<213>  Homo Sapiens

<400>  9274

Met Asn Lys Pro Ser Asp Gly Arg Pro Lys Tyr Leu Val Val Asn Ala 
1               5                   10                  15      


Asp Glu Gly Glu Pro Gly Thr Cys Lys Asp Arg Glu Ile Leu Arg His 
            20                  25                  30          


Asp Pro His Lys Leu Leu Glu Gly Cys Leu Val Gly Gly Arg Ala Met 
        35                  40                  45              


Gly Ala Arg Ala Ala Tyr Ile Tyr Ile Arg Gly Glu Phe Tyr Asn Glu 
    50                  55                  60                  


Ala Ser Asn Leu Gln Val Ala Ile Arg Glu Ala Tyr Glu Ala Gly Leu 
65                  70                  75                  80  


Ile Gly Lys Asn Ala Cys Gly Ser Gly Tyr Asp Phe Asp Val Phe Val 
                85                  90                  95      


Val Arg Gly Ala Gly Ala Tyr Ile Cys Gly Glu Glu Thr Ala Leu Ile 
            100                 105                 110         


Glu Ser Ile Glu Gly Lys Gln Gly Lys Pro Arg Leu Lys Pro Pro Phe 
        115                 120                 125             


Pro Ala Asp Val Gly Lys Ala Trp 
    130                 135     


<210>  9275
<211>  363
<212>  PRT
<213>  Homo Sapiens

<400>  9275

Met Asn Lys Pro Ser Asp Gly Arg Pro Lys Tyr Leu Val Val Asn Ala 
1               5                   10                  15      


Asp Glu Gly Glu Pro Gly Thr Cys Lys Asp Arg Glu Ile Leu Arg His 
            20                  25                  30          


Asp Pro His Lys Leu Leu Glu Gly Cys Leu Val Gly Gly Arg Ala Met 
        35                  40                  45              


Gly Ala Arg Ala Ala Tyr Ile Tyr Ile Arg Gly Glu Phe Tyr Asn Glu 
    50                  55                  60                  


Ala Ser Asn Leu Gln Val Ala Ile Arg Glu Ala Tyr Glu Ala Gly Leu 
65                  70                  75                  80  


Ile Gly Lys Asn Ala Cys Gly Ser Gly Tyr Asp Phe Asp Val Phe Val 
                85                  90                  95      


Val Arg Gly Ala Gly Ala Tyr Ile Cys Gly Glu Glu Thr Ala Leu Ile 
            100                 105                 110         


Glu Ser Ile Glu Gly Lys Gln Gly Lys Pro Arg Leu Lys Pro Pro Phe 
        115                 120                 125             


Pro Ala Asp Val Gly Val Phe Gly Cys Pro Thr Thr Val Ala Asn Val 
    130                 135                 140                 


Glu Thr Val Ala Val Ser Pro Thr Ile Cys Arg Arg Gly Gly Thr Trp 
145                 150                 155                 160 


Phe Ala Gly Phe Gly Arg Glu Arg Asn Ser Gly Thr Lys Leu Phe Asn 
                165                 170                 175     


Ile Ser Gly His Val Asn His Pro Cys Thr Val Glu Glu Glu Met Ser 
            180                 185                 190         


Val Pro Leu Lys Glu Leu Ile Glu Lys His Ala Gly Gly Val Thr Gly 
        195                 200                 205             


Gly Trp Asp Asn Leu Leu Ala Val Ile Pro Gly Gly Ser Ser Thr Pro 
    210                 215                 220                 


Leu Ile Pro Lys Ser Val Cys Glu Thr Val Leu Met Asp Phe Asp Ala 
225                 230                 235                 240 


Leu Val Gln Ala Gln Thr Gly Leu Gly Thr Ala Ala Val Ile Val Met 
                245                 250                 255     


Asp Arg Ser Thr Asp Ile Val Lys Ala Ile Ala Arg Leu Ile Glu Phe 
            260                 265                 270         


Tyr Lys His Glu Ser Cys Gly Gln Cys Thr Pro Cys Arg Glu Gly Val 
        275                 280                 285             


Asp Trp Met Asn Lys Val Met Ala Arg Phe Val Arg Gly Asp Ala Arg 
    290                 295                 300                 


Pro Ala Glu Ile Asp Ser Leu Trp Glu Ile Ser Lys Gln Ile Glu Gly 
305                 310                 315                 320 


His Thr Ile Cys Ala Leu Gly Asp Gly Ala Ala Trp Pro Val Gln Gly 
                325                 330                 335     


Leu Ile Arg His Phe Arg Pro Glu Leu Glu Glu Arg Met Gln Arg Phe 
            340                 345                 350         


Ala Gln Gln His Gln Ala Arg Gln Ala Ala Ser 
        355                 360             


<210>  9276
<211>  54
<212>  PRT
<213>  Homo Sapiens

<400>  9276

Met Ala Cys Ala Gly Leu Leu Thr Val Cys Leu Leu Arg Pro Pro Ala 
1               5                   10                  15      


Pro Gln Pro Gln Pro Gln Thr Pro Arg His Pro Gln Leu Ala Pro Asp 
            20                  25                  30          


Pro Gly Pro Ala Gly His Thr Leu Phe Gln Asp Val Phe Arg Arg Ala 
        35                  40                  45              


Asp Lys Asn Ala Leu Ile 
    50                  


<210>  9277
<211>  210
<212>  PRT
<213>  Homo Sapiens

<400>  9277

Met Ala Cys Ala Gly Leu Leu Thr Val Cys Leu Leu Arg Pro Pro Ala 
1               5                   10                  15      


Pro Gln Pro Gln Pro Gln Thr Pro Arg His Pro Gln Leu Ala Pro Asp 
            20                  25                  30          


Pro Gly Pro Ala Gly His Thr Leu Phe Gln Asp Val Phe Arg Arg Ala 
        35                  40                  45              


Asp Lys Asn Asp Asp Gly Lys Leu Ser Phe Glu Glu Phe Gln Asn Tyr 
    50                  55                  60                  


Phe Ala Asp Gly Val Leu Ser Leu Gly Glu Leu Gln Glu Leu Phe Ser 
65                  70                  75                  80  


Gly Ile Asp Gly His Leu Thr Asp Asn Leu Glu Thr Glu Lys Leu Cys 
                85                  90                  95      


Asp Tyr Phe Ser Glu His Leu Gly Val Tyr Arg Pro Val Leu Ala Ala 
            100                 105                 110         


Leu Glu Ser Leu Asn Arg Ala Val Leu Ala Ala Met Asp Ala Thr Lys 
        115                 120                 125             


Leu Glu Tyr Glu Arg Ala Ser Lys Val Asp Gln Phe Val Thr Arg Phe 
    130                 135                 140                 


Leu Leu Arg Glu Thr Val Ser Gln Leu Gln Ala Leu Gln Ser Ser Leu 
145                 150                 155                 160 


Glu Gly Ala Ser Asp Thr Leu Glu Ala Gln Ala His Gly Trp Arg Cys 
                165                 170                 175     


Arg Glu Arg Gly Gly Ala Glu Gln Ala Leu Arg Gln Pro Ala Gly Arg 
            180                 185                 190         


Thr Pro Ser Pro Glu Glu Cys Gln Pro Val Ile His Leu Val Pro Arg 
        195                 200                 205             


Leu Phe 
    210 


<210>  9278
<211>  192
<212>  PRT
<213>  Homo Sapiens

<400>  9278

Met Ala Cys Ala Gly Leu Leu Thr Val Cys Leu Leu Arg Pro Pro Ala 
1               5                   10                  15      


Pro Gln Pro Gln Pro Gln Thr Pro Arg His Pro Gln Leu Ala Pro Asp 
            20                  25                  30          


Pro Gly Pro Ala Gly His Thr Leu Phe Gln Asp Val Phe Arg Arg Ala 
        35                  40                  45              


Asp Lys Asn Asp Asp Gly Lys Leu Ser Phe Glu Glu Phe Gln Asn Tyr 
    50                  55                  60                  


Phe Ala Asp Gly Val Leu Ser Leu Gly Glu Leu Gln Glu Leu Phe Ser 
65                  70                  75                  80  


Gly Ile Asp Gly His Leu Thr Asp Asn Leu Glu Thr Glu Lys Leu Cys 
                85                  90                  95      


Asp Tyr Phe Ser Glu His Leu Gly Val Tyr Arg Pro Val Leu Ala Ala 
            100                 105                 110         


Leu Glu Ser Leu Asn Arg Ala Val Leu Ala Ala Met Asp Ala Thr Lys 
        115                 120                 125             


Leu Glu Tyr Glu Arg Ala Ser Lys Val Asp Gln Phe Val Thr Arg Phe 
    130                 135                 140                 


Leu Leu Arg Glu Thr Val Ser Gln Leu Gln Ala Leu Gln Ser Ser Leu 
145                 150                 155                 160 


Glu Gly Ala Ser Asp Thr Leu Glu Ala Gln Ala His Gly Trp Arg Leu 
                165                 170                 175     


Ile Pro Ser Trp Gly Pro Ser Pro Arg Pro Cys Glu Pro His Phe Leu 
            180                 185                 190         


<210>  9279
<211>  362
<212>  PRT
<213>  Homo Sapiens

<400>  9279

Met Ala Cys Ala Gly Leu Leu Thr Val Cys Leu Leu Arg Pro Pro Ala 
1               5                   10                  15      


Pro Gln Pro Gln Pro Gln Thr Pro Arg His Pro Gln Leu Ala Pro Asp 
            20                  25                  30          


Pro Gly Pro Ala Gly His Thr Leu Phe Gln Asp Val Phe Arg Arg Ala 
        35                  40                  45              


Asp Lys Asn Asp Asp Gly Lys Leu Ser Phe Glu Glu Phe Gln Asn Tyr 
    50                  55                  60                  


Phe Ala Asp Gly Val Leu Ser Leu Gly Glu Leu Gln Glu Leu Phe Ser 
65                  70                  75                  80  


Gly Ile Asp Gly His Leu Thr Asp Asn Leu Glu Thr Glu Lys Leu Cys 
                85                  90                  95      


Asp Tyr Phe Ser Glu His Leu Gly Val Tyr Arg Pro Val Leu Ala Ala 
            100                 105                 110         


Leu Glu Ser Leu Asn Arg Ala Val Leu Ala Ala Met Asp Ala Thr Lys 
        115                 120                 125             


Leu Glu Tyr Glu Arg Ala Ser Lys Val Asp Gln Phe Val Thr Arg Phe 
    130                 135                 140                 


Leu Leu Arg Glu Thr Val Ser Gln Leu Gln Ala Leu Gln Ser Ser Leu 
145                 150                 155                 160 


Glu Gly Ala Ser Asp Thr Leu Glu Ala Gln Ala His Gly Trp Arg Ser 
                165                 170                 175     


Asp Ala Glu Ser Val Glu Ala Gln Ser Arg Leu Cys Gly Ser Arg Arg 
            180                 185                 190         


Ala Gly Arg Arg Ala Leu Arg Ser Val Ser Arg Ser Ser Thr Trp Ser 
        195                 200                 205             


Pro Gly Ser Ser Asp Thr Gly Arg Ser Ser Glu Ala Glu Met Gln Trp 
    210                 215                 220                 


Arg Leu Gln Val Asn Arg Leu Gln Glu Leu Ile Asp Gln Leu Glu Cys 
225                 230                 235                 240 


Lys Ala Pro Arg Leu Glu Pro Leu Arg Glu Glu Asp Leu Ala Lys Gly 
                245                 250                 255     


Pro Asp Leu His Ile Leu Met Ala Gln Arg Gln Val Gln Val Ala Glu 
            260                 265                 270         


Glu Gly Leu Gln Asp Phe His Arg Ala Leu Arg Cys Tyr Val Asp Phe 
        275                 280                 285             


Thr Gly Ala Gln Ser His Cys Leu His Val Ser Ala Gln Lys Met Leu 
    290                 295                 300                 


Asp Gly Ala Ser Phe Thr Leu Tyr Glu Phe Trp Gln Asp Glu Ala Ser 
305                 310                 315                 320 


Trp Arg Arg His Gln Gln Ser Pro Gly Ser Lys Ala Phe Gln Arg Ile 
                325                 330                 335     


Leu Ile Asp His Leu Arg Ala Pro Asp Thr Leu Thr Thr Val Phe Phe 
            340                 345                 350         


Pro Ala Ser Trp Trp Ile Met Asn Asn Asn 
        355                 360         


<210>  9280
<211>  289
<212>  PRT
<213>  Homo Sapiens

<400>  9280

Met Ala Cys Ala Gly Leu Leu Thr Val Cys Leu Leu Arg Pro Pro Ala 
1               5                   10                  15      


Pro Gln Pro Gln Pro Gln Thr Pro Arg His Pro Gln Leu Ala Pro Asp 
            20                  25                  30          


Pro Gly Pro Ala Gly His Thr Leu Phe Gln Asp Val Phe Arg Arg Ala 
        35                  40                  45              


Asp Lys Asn Asp Asp Gly Lys Leu Ser Phe Glu Glu Phe Gln Asn Tyr 
    50                  55                  60                  


Phe Ala Asp Gly Val Leu Ser Leu Gly Glu Leu Gln Glu Leu Phe Ser 
65                  70                  75                  80  


Gly Ile Asp Gly His Leu Thr Asp Asn Leu Glu Thr Glu Lys Leu Cys 
                85                  90                  95      


Asp Tyr Phe Ser Glu His Leu Gly Val Tyr Arg Pro Val Leu Ala Ala 
            100                 105                 110         


Leu Glu Ser Leu Asn Arg Ala Val Leu Ala Ala Met Asp Ala Thr Lys 
        115                 120                 125             


Leu Glu Tyr Glu Arg Ala Ser Lys Val Asp Gln Phe Val Thr Arg Phe 
    130                 135                 140                 


Leu Leu Arg Glu Thr Val Ser Gln Leu Gln Ala Leu Gln Ser Ser Leu 
145                 150                 155                 160 


Glu Gly Ala Ser Asp Thr Leu Glu Ala Gln Ala His Gly Trp Arg Ser 
                165                 170                 175     


Asp Ala Glu Ser Val Glu Ala Gln Ser Arg Leu Cys Gly Ser Arg Arg 
            180                 185                 190         


Ala Gly Arg Arg Ala Leu Arg Ser Val Ser Arg Ser Ser Thr Trp Ser 
        195                 200                 205             


Pro Gly Ser Ser Asp Thr Gly Arg Ser Ser Glu Ala Glu Met Gln Trp 
    210                 215                 220                 


Arg Leu Gln Val Asn Arg Leu Gln Glu Leu Ile Asp Gln Leu Glu Cys 
225                 230                 235                 240 


Lys His Ile Leu Met Ala Gln Arg Gln Val Gln Val Ala Glu Glu Gly 
                245                 250                 255     


Leu Gln Asp Phe His Arg Ala Leu Arg Cys Tyr Val Asp Phe Thr Gly 
            260                 265                 270         


Ala Gln Ser His Cys Leu His Val Ser Ala Gln Lys Met Leu Asp Gly 
        275                 280                 285             


Ala 
    


<210>  9281
<211>  297
<212>  PRT
<213>  Homo Sapiens

<400>  9281

Met Ala Cys Ala Gly Leu Leu Thr Val Cys Leu Leu Arg Pro Pro Ala 
1               5                   10                  15      


Pro Gln Pro Gln Pro Gln Thr Pro Arg His Pro Gln Leu Ala Pro Asp 
            20                  25                  30          


Pro Gly Pro Ala Gly His Thr Leu Phe Gln Asp Val Phe Arg Arg Ala 
        35                  40                  45              


Asp Lys Asn Asp Asp Gly Lys Leu Ser Phe Glu Glu Phe Gln Asn Tyr 
    50                  55                  60                  


Phe Ala Asp Gly Val Leu Ser Leu Gly Glu Leu Gln Glu Leu Phe Ser 
65                  70                  75                  80  


Gly Ile Asp Gly His Leu Thr Asp Asn Leu Glu Thr Glu Lys Leu Cys 
                85                  90                  95      


Asp Tyr Phe Ser Glu His Leu Gly Val Tyr Arg Pro Val Leu Ala Ala 
            100                 105                 110         


Leu Glu Ser Leu Asn Arg Ala Val Leu Ala Ala Met Asp Ala Thr Lys 
        115                 120                 125             


Leu Glu Tyr Glu Arg Ala Ser Lys Val Asp Gln Phe Val Thr Arg Phe 
    130                 135                 140                 


Leu Leu Arg Glu Thr Val Ser Gln Leu Gln Ala Leu Gln Ser Ser Leu 
145                 150                 155                 160 


Glu Gly Ala Ser Asp Thr Leu Glu Ala Gln Ala His Gly Trp Arg Ser 
                165                 170                 175     


Asp Ala Glu Ser Val Glu Ala Gln Ser Arg Leu Cys Gly Ser Arg Arg 
            180                 185                 190         


Ala Gly Arg Arg Ala Leu Arg Ser Val Ser Arg Ser Ser Thr Trp Ser 
        195                 200                 205             


Pro Gly Ser Ser Asp Thr Gly Arg Ser Ser Glu Ala Glu Met Gln Trp 
    210                 215                 220                 


Arg Leu Gln Val Asn Arg Leu Gln Glu Leu Ile Asp Gln Leu Glu Cys 
225                 230                 235                 240 


Lys Arg Gln Val Gln Val Ala Glu Glu Gly Leu Gln Asp Phe His Arg 
                245                 250                 255     


Ala Leu Arg Cys Tyr Val Asp Phe Thr Gly Ala Gln Ser His Cys Leu 
            260                 265                 270         


His Val Ser Ala Gln Lys Met Leu Asp Gly Ala Ser Phe Thr Leu Tyr 
        275                 280                 285             


Glu Phe Trp Gln Asp Glu Ala Ser Trp 
    290                 295         


<210>  9282
<211>  396
<212>  PRT
<213>  Homo Sapiens

<400>  9282

Met Ala Cys Ala Gly Leu Leu Thr Val Cys Leu Leu Arg Pro Pro Ala 
1               5                   10                  15      


Pro Gln Pro Gln Pro Gln Thr Pro Arg His Pro Gln Leu Ala Pro Asp 
            20                  25                  30          


Pro Gly Pro Ala Gly His Thr Leu Phe Gln Asp Val Phe Arg Arg Ala 
        35                  40                  45              


Asp Lys Asn Asp Asp Gly Lys Leu Ser Phe Glu Glu Phe Gln Asn Tyr 
    50                  55                  60                  


Phe Ala Asp Gly Val Leu Ser Leu Gly Glu Leu Gln Glu Leu Phe Ser 
65                  70                  75                  80  


Gly Ile Asp Gly His Leu Thr Asp Asn Leu Glu Thr Glu Lys Leu Cys 
                85                  90                  95      


Asp Tyr Phe Ser Glu His Leu Gly Val Tyr Arg Pro Val Leu Ala Ala 
            100                 105                 110         


Leu Glu Ser Leu Asn Arg Ala Val Leu Ala Ala Met Asp Ala Thr Lys 
        115                 120                 125             


Leu Glu Tyr Glu Arg Ala Ser Lys Val Asp Gln Phe Val Thr Arg Phe 
    130                 135                 140                 


Leu Leu Arg Glu Thr Val Ser Gln Leu Gln Ala Leu Gln Ser Ser Leu 
145                 150                 155                 160 


Glu Gly Ala Ser Asp Thr Leu Glu Ala Gln Ala His Gly Trp Arg Ser 
                165                 170                 175     


Asp Ala Glu Ser Val Glu Ala Gln Ser Arg Leu Cys Gly Ser Arg Arg 
            180                 185                 190         


Ala Gly Arg Arg Ala Leu Arg Ser Val Ser Arg Ser Ser Thr Trp Ser 
        195                 200                 205             


Pro Gly Ser Ser Asp Thr Gly Arg Ser Ser Glu Ala Glu Met Gln Trp 
    210                 215                 220                 


Arg Leu Gln Val Asn Arg Leu Gln Glu Leu Ile Asp Gln Leu Glu Cys 
225                 230                 235                 240 


Lys Val Arg Ala Val Gly Pro Gly Pro His Lys Gly Gly Pro Ser Trp 
                245                 250                 255     


Tyr Pro Pro Glu Pro Gly Pro Cys Trp Arg Pro Gly Pro His Ser Val 
            260                 265                 270         


Pro Ser Gln Ala Pro Arg Leu Glu Pro Leu Arg Glu Glu Asp Leu Ala 
        275                 280                 285             


Lys Gly Pro Asp Leu His Ile Leu Met Ala Gln Arg Gln Val Gln Val 
    290                 295                 300                 


Ala Glu Glu Gly Leu Gln Asp Phe His Arg Ala Leu Arg Cys Tyr Val 
305                 310                 315                 320 


Asp Phe Thr Gly Ala Gln Ser His Cys Leu His Val Ser Ala Gln Lys 
                325                 330                 335     


Met Leu Asp Gly Ala Ser Phe Thr Leu Tyr Glu Phe Trp Gln Asp Glu 
            340                 345                 350         


Ala Ser Trp Arg Arg His Gln Gln Ser Pro Gly Ser Lys Ala Phe Gln 
        355                 360                 365             


Arg Ile Leu Ile Asp His Leu Arg Ala Pro Asp Thr Leu Thr Thr Val 
    370                 375                 380                 


Phe Phe Pro Ala Ser Trp Trp Ile Met Asn Asn Asn 
385                 390                 395     


<210>  9283
<211>  71
<212>  PRT
<213>  Homo Sapiens

<400>  9283

Met Ala Cys Ala Gly Leu Leu Thr Val Cys Leu Leu Arg Pro Pro Ala 
1               5                   10                  15      


Pro Gln Pro Gln Pro Gln Thr Pro Arg His Pro Gln Leu Ala Pro Asp 
            20                  25                  30          


Pro Gly Pro Ala Gly His Thr Leu Phe Gln Asp Val Phe Arg Arg Ala 
        35                  40                  45              


Asp Lys Asn Glu Leu Leu Cys Arg Trp Gly Ser Gln Pro Gly Gly Ala 
    50                  55                  60                  


Ala Gly Thr Val Gln Arg His 
65                  70      


<210>  9284
<211>  126
<212>  PRT
<213>  Homo Sapiens

<400>  9284

Met Gln Trp Arg Leu Gln Val Asn Arg Leu Gln Glu Leu Ile Asp Gln 
1               5                   10                  15      


Leu Glu Cys Lys Ala Pro Arg Leu Glu Pro Leu Arg Glu Glu Asp Leu 
            20                  25                  30          


Ala Lys Gly Pro Asp Leu His Ile Leu Met Ala Gln Arg Gln Val Gln 
        35                  40                  45              


Val Ala Glu Glu Gly Leu Gln Asp Phe His Arg Ala Leu Arg Cys Tyr 
    50                  55                  60                  


Val Asp Phe Thr Gly Ala Gln Ser His Cys Leu His Val Ser Ala Gln 
65                  70                  75                  80  


Lys Met Leu Asp Gly Ala Ser Phe Thr Leu Tyr Glu Phe Trp Gln Asp 
                85                  90                  95      


Glu Ala Ser Trp Arg Arg His Gln Gln Ser Pro Gly Ser Lys Ala Phe 
            100                 105                 110         


Gln Arg Ile Leu Ile Asp His Leu Arg Ala Pro Asp Thr Leu 
        115                 120                 125     


<210>  9285
<211>  95
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9285

Xaa Gln Asn Tyr Phe Ala Asp Gly Val Leu Ser Leu Gly Glu Leu Gln 
1               5                   10                  15      


Glu Leu Phe Ser Gly Ile Asp Gly His Leu Thr Asp Asn Leu Glu Thr 
            20                  25                  30          


Glu Lys Leu Cys Asp Tyr Phe Ser Glu His Leu Gly Val Tyr Arg Pro 
        35                  40                  45              


Val Leu Ala Ala Leu Glu Ser Leu Asn Arg Ala Val Leu Ala Ala Met 
    50                  55                  60                  


Asp Ala Thr Lys Leu Val Ser Gly Val Ala Asp Gly Gly Gly Ser Thr 
65                  70                  75                  80  


Val Arg Gln Trp Ala Ser Ala Val Leu Trp Asp Pro Pro Gln Ser 
                85                  90                  95  


<210>  9286
<211>  517
<212>  PRT
<213>  Homo Sapiens

<400>  9286

Met Ala Arg Met Gly Leu Ala Gly Ala Ala Gly Arg Trp Trp Gly Leu 
1               5                   10                  15      


Ala Leu Gly Leu Thr Ala Phe Phe Leu Pro Gly Val His Ser Gln Val 
            20                  25                  30          


Val Gln Val Asn Asp Ser Met Tyr Gly Phe Ile Gly Thr Asp Val Val 
        35                  40                  45              


Leu His Cys Ser Phe Ala Asn Pro Leu Pro Ser Val Lys Ile Thr Gln 
    50                  55                  60                  


Val Thr Trp Gln Lys Ser Thr Asn Gly Ser Lys Gln Asn Val Ala Ile 
65                  70                  75                  80  


Tyr Asn Pro Ser Met Gly Val Ser Val Leu Ala Pro Tyr Arg Glu Arg 
                85                  90                  95      


Val Glu Phe Leu Arg Pro Ser Phe Thr Asp Gly Thr Ile Arg Leu Ser 
            100                 105                 110         


Arg Leu Glu Leu Glu Asp Glu Gly Val Tyr Ile Cys Glu Phe Ala Thr 
        115                 120                 125             


Phe Pro Thr Gly Asn Arg Glu Ser Gln Leu Asn Leu Thr Val Met Ala 
    130                 135                 140                 


Lys Pro Thr Asn Trp Ile Glu Gly Thr Gln Ala Val Leu Arg Ala Lys 
145                 150                 155                 160 


Lys Gly Gln Asp Asp Lys Val Leu Val Ala Thr Cys Thr Ser Ala Asn 
                165                 170                 175     


Gly Lys Pro Pro Ser Val Val Ser Trp Glu Thr Arg Leu Lys Gly Glu 
            180                 185                 190         


Ala Glu Tyr Gln Glu Ile Arg Asn Pro Asn Gly Thr Val Thr Val Ile 
        195                 200                 205             


Ser Arg Tyr Arg Leu Val Pro Ser Arg Glu Ala His Gln Gln Ser Leu 
    210                 215                 220                 


Ala Cys Ile Val Asn Tyr His Met Asp Arg Phe Lys Glu Ser Leu Thr 
225                 230                 235                 240 


Leu Asn Val Gln Tyr Glu Pro Glu Val Thr Ile Glu Gly Phe Asp Gly 
                245                 250                 255     


Asn Trp Tyr Leu Gln Arg Met Asp Val Lys Leu Thr Cys Lys Ala Asp 
            260                 265                 270         


Ala Asn Pro Pro Ala Thr Glu Tyr His Trp Thr Thr Leu Asn Gly Ser 
        275                 280                 285             


Leu Pro Lys Gly Val Glu Ala Gln Asn Arg Thr Leu Phe Phe Lys Gly 
    290                 295                 300                 


Pro Ile Asn Tyr Ser Leu Ala Gly Thr Tyr Ile Cys Glu Ala Thr Asn 
305                 310                 315                 320 


Pro Ile Gly Thr Arg Ser Gly Gln Val Glu Val Asn Ile Thr Glu Phe 
                325                 330                 335     


Pro Tyr Thr Pro Ser Pro Pro Glu His Gly Arg Arg Ala Gly Pro Val 
            340                 345                 350         


Pro Thr Ala Ile Ile Gly Gly Val Ala Gly Ser Ile Leu Leu Val Leu 
        355                 360                 365             


Ile Val Val Gly Gly Ile Val Val Ala Leu Arg Arg Arg Arg His Thr 
    370                 375                 380                 


Phe Lys Gly Asp Tyr Ser Thr Lys Lys His Val Tyr Gly Asn Gly Tyr 
385                 390                 395                 400 


Ser Lys Ala Gly Ile Pro Gln His His Pro Pro Met Ala Gln Asn Leu 
                405                 410                 415     


Gln Tyr Pro Asp Asp Ser Asp Asp Glu Lys Lys Ala Gly Pro Leu Gly 
            420                 425                 430         


Gly Ser Ser Tyr Glu Glu Glu Glu Glu Glu Glu Glu Gly Gly Gly Gly 
        435                 440                 445             


Gly Glu Arg Lys Val Gly Gly Pro His Pro Lys Tyr Asp Glu Asp Ala 
    450                 455                 460                 


Lys Arg Pro Tyr Phe Thr Val Asp Glu Ala Glu Ala Arg Gln Asp Gly 
465                 470                 475                 480 


Tyr Gly Asp Arg Thr Leu Gly Tyr Gln Tyr Asp Pro Glu Gln Leu Asp 
                485                 490                 495     


Leu Ala Glu Asn Met Val Ser Gln Asn Asp Gly Ser Phe Ile Ser Lys 
            500                 505                 510         


Lys Glu Trp Tyr Val 
        515         


<210>  9287
<211>  458
<212>  PRT
<213>  Homo Sapiens

<400>  9287

Met Ala Arg Met Gly Leu Ala Gly Ala Ala Gly Arg Trp Trp Gly Leu 
1               5                   10                  15      


Ala Leu Gly Leu Thr Ala Phe Phe Leu Pro Gly Val His Ser Gln Val 
            20                  25                  30          


Val Gln Val Asn Asp Ser Met Tyr Gly Phe Ile Gly Thr Asp Val Val 
        35                  40                  45              


Leu His Cys Ser Phe Ala Asn Pro Leu Pro Ser Val Lys Ile Thr Gln 
    50                  55                  60                  


Val Thr Trp Gln Lys Ser Thr Asn Gly Ser Lys Gln Asn Val Ala Ile 
65                  70                  75                  80  


Tyr Asn Pro Ser Met Gly Val Ser Val Leu Ala Pro Tyr Arg Glu Arg 
                85                  90                  95      


Val Glu Phe Leu Arg Pro Ser Phe Thr Asp Gly Thr Ile Arg Leu Ser 
            100                 105                 110         


Arg Leu Glu Leu Glu Asp Glu Gly Val Tyr Ile Cys Glu Phe Ala Thr 
        115                 120                 125             


Phe Pro Thr Gly Asn Arg Glu Ser Gln Leu Asn Leu Thr Val Met Ala 
    130                 135                 140                 


Lys Pro Thr Asn Trp Ile Glu Gly Thr Gln Ala Val Leu Arg Ala Lys 
145                 150                 155                 160 


Lys Gly Gln Asp Asp Lys Val Leu Val Ala Thr Cys Thr Ser Ala Asn 
                165                 170                 175     


Gly Lys Pro Pro Ser Val Val Ser Trp Glu Thr Arg Leu Lys Gly Glu 
            180                 185                 190         


Ala Glu Tyr Gln Glu Ile Arg Asn Pro Asn Gly Thr Val Thr Val Ile 
        195                 200                 205             


Ser Arg Tyr Arg Leu Val Pro Ser Arg Glu Ala His Gln Gln Ser Leu 
    210                 215                 220                 


Ala Cys Ile Val Asn Tyr His Met Asp Arg Phe Lys Glu Ser Leu Thr 
225                 230                 235                 240 


Leu Asn Val Gln Tyr Glu Pro Glu Val Thr Ile Glu Gly Phe Asp Gly 
                245                 250                 255     


Asn Trp Tyr Leu Gln Arg Met Asp Val Lys Leu Thr Cys Lys Ala Asp 
            260                 265                 270         


Ala Asn Pro Pro Ala Thr Glu Tyr His Trp Thr Thr Leu Asn Gly Ser 
        275                 280                 285             


Leu Pro Lys Gly Val Glu Ala Gln Asn Arg Thr Leu Phe Phe Lys Gly 
    290                 295                 300                 


Pro Ile Asn Tyr Ser Leu Ala Gly Thr Tyr Ile Cys Glu Ala Thr Asn 
305                 310                 315                 320 


Pro Ile Gly Thr Arg Ser Gly Gln Val Glu Val Asn Ile Thr Glu Lys 
                325                 330                 335     


Pro Arg Pro Gln Arg Gly Leu Gly Ser Ala Ala Arg Leu Leu Ala Gly 
            340                 345                 350         


Thr Val Ala Val Phe Leu Ile Leu Val Ala Val Leu Thr Val Phe Phe 
        355                 360                 365             


Leu Tyr Asn Arg Gln Gln Lys Ser Pro Pro Glu Thr Asp Gly Ala Gly 
    370                 375                 380                 


Thr Asp Gln Pro Leu Ser Gln Lys Pro Glu Pro Ser Pro Ser Arg Gln 
385                 390                 395                 400 


Ser Ser Leu Val Pro Glu Asp Ile Gln Val Val His Leu Asp Pro Gly 
                405                 410                 415     


Arg Gln Gln Gln Gln Glu Glu Glu Asp Leu Gln Lys Leu Ser Leu Gln 
            420                 425                 430         


Pro Pro Tyr Tyr Asp Leu Gly Val Ser Pro Ser Tyr His Pro Ser Val 
        435                 440                 445             


Arg Thr Thr Glu Pro Arg Gly Glu Cys Pro 
    450                 455             


<210>  9288
<211>  352
<212>  PRT
<213>  Homo Sapiens

<400>  9288

Met Ala Arg Met Gly Leu Ala Gly Ala Ala Gly Arg Trp Trp Gly Leu 
1               5                   10                  15      


Ala Leu Gly Leu Thr Ala Phe Phe Leu Pro Gly Val His Ser Gln Val 
            20                  25                  30          


Val Gln Val Asn Asp Ser Met Tyr Gly Phe Ile Gly Thr Asp Val Val 
        35                  40                  45              


Leu His Cys Ser Phe Ala Asn Pro Leu Pro Ser Val Lys Ile Thr Gln 
    50                  55                  60                  


Val Thr Trp Gln Lys Ser Thr Asn Gly Ser Lys Gln Asn Val Ala Ile 
65                  70                  75                  80  


Tyr Asn Pro Ser Met Gly Val Ser Val Leu Ala Pro Tyr Arg Glu Arg 
                85                  90                  95      


Val Glu Phe Leu Arg Pro Ser Phe Thr Asp Gly Thr Ile Arg Leu Ser 
            100                 105                 110         


Arg Leu Glu Leu Glu Asp Glu Gly Val Tyr Ile Cys Glu Phe Ala Thr 
        115                 120                 125             


Phe Pro Thr Gly Asn Arg Glu Ser Gln Leu Asn Leu Thr Val Met Ala 
    130                 135                 140                 


Lys Pro Thr Asn Trp Ile Glu Gly Thr Gln Ala Val Leu Arg Ala Lys 
145                 150                 155                 160 


Lys Gly Gln Asp Asp Lys Val Leu Val Ala Thr Cys Thr Ser Ala Asn 
                165                 170                 175     


Gly Lys Pro Pro Ser Val Val Ser Trp Glu Thr Arg Leu Lys Gly Glu 
            180                 185                 190         


Ala Glu Tyr Gln Glu Ile Arg Asn Pro Asn Gly Thr Val Thr Val Ile 
        195                 200                 205             


Ser Arg Tyr Arg Leu Val Pro Ser Arg Glu Ala His Gln Gln Ser Leu 
    210                 215                 220                 


Ala Cys Ile Val Asn Tyr His Met Asp Arg Phe Lys Glu Ser Leu Thr 
225                 230                 235                 240 


Leu Asn Val Gln Tyr Glu Pro Glu Val Thr Ile Glu Gly Phe Asp Gly 
                245                 250                 255     


Asn Trp Tyr Leu Gln Arg Met Asp Val Lys Leu Thr Cys Lys Ala Asp 
            260                 265                 270         


Ala Asn Pro Pro Ala Thr Glu Tyr His Trp Thr Thr Leu Asn Gly Ser 
        275                 280                 285             


Leu Pro Lys Gly Val Glu Ala Gln Asn Arg Thr Leu Phe Phe Lys Gly 
    290                 295                 300                 


Pro Ile Asn Tyr Ser Leu Ala Gly Thr Tyr Ile Cys Glu Ala Thr Asn 
305                 310                 315                 320 


Pro Ile Gly Thr Arg Ser Gly Gln Val Glu Val Asn Ile Thr Ala Phe 
                325                 330                 335     


Cys Gln Leu Ile Tyr Pro Gly Lys Gly Arg Thr Arg Ala Arg Met Phe 
            340                 345                 350         


<210>  9289
<211>  838
<212>  PRT
<213>  Homo Sapiens

<400>  9289

Met Pro Met Asp Leu Ile Leu Val Val Trp Phe Cys Val Cys Thr Ala 
1               5                   10                  15      


Arg Thr Ala Glu Asp Met Lys Pro Pro Val Leu Ser Leu Ile Trp Arg 
            20                  25                  30          


Thr Arg Val Leu Lys Ser Leu Leu Gln Gln Ser Leu Gln Gly Val Val 
        35                  40                  45              


Gly Phe Gly Met Asp Pro Asp Leu Gln Met Asp Ile Val Thr Glu Leu 
    50                  55                  60                  


Asp Leu Val Asn Thr Thr Leu Gly Val Ala Gln Val Ser Gly Met His 
65                  70                  75                  80  


Asn Ala Ser Lys Ala Phe Leu Phe Gln Asp Ile Glu Arg Glu Ile His 
                85                  90                  95      


Ala Ala Pro His Val Ser Glu Lys Leu Ile Gln Leu Phe Arg Asn Lys 
            100                 105                 110         


Ser Glu Phe Thr Ile Leu Ala Thr Val Gln Gln Lys Pro Ser Thr Ser 
        115                 120                 125             


Gly Val Ile Leu Ser Ile Arg Glu Leu Glu His Ser Tyr Phe Glu Leu 
    130                 135                 140                 


Glu Ser Ser Gly Leu Arg Asp Glu Ile Arg Tyr His Tyr Ile His Asn 
145                 150                 155                 160 


Gly Lys Pro Arg Thr Glu Ala Leu Pro Tyr Arg Met Ala Asp Gly Gln 
                165                 170                 175     


Trp His Lys Val Ala Leu Ser Val Ser Ala Ser His Leu Leu Leu His 
            180                 185                 190         


Val Asp Cys Asn Arg Ile Tyr Glu Arg Val Ile Asp Pro Pro Asp Thr 
        195                 200                 205             


Asn Leu Pro Pro Gly Ile Asn Leu Trp Leu Gly Gln Arg Asn Gln Lys 
    210                 215                 220                 


His Gly Leu Phe Lys Gly Ile Ile Gln Asp Gly Lys Ile Ile Phe Met 
225                 230                 235                 240 


Pro Asn Gly Tyr Ile Thr Gln Cys Pro Asn Leu Asn His Thr Cys Pro 
                245                 250                 255     


Thr Cys Ser Asp Phe Leu Ser Leu Val Gln Gly Ile Met Asp Leu Gln 
            260                 265                 270         


Glu Leu Leu Ala Lys Met Thr Ala Lys Leu Asn Tyr Ala Glu Thr Arg 
        275                 280                 285             


Leu Ser Gln Leu Glu Asn Cys His Cys Glu Lys Thr Cys Gln Val Ser 
    290                 295                 300                 


Gly Leu Leu Tyr Arg Asp Gln Asp Ser Trp Val Asp Gly Asp His Cys 
305                 310                 315                 320 


Arg Asn Cys Thr Cys Lys Ser Gly Ala Val Glu Cys Arg Arg Met Ser 
                325                 330                 335     


Cys Pro Pro Leu Asn Cys Ser Pro Asp Ser Leu Pro Val His Ile Ala 
            340                 345                 350         


Gly Gln Cys Cys Lys Val Cys Arg Pro Lys Cys Ile Tyr Gly Gly Lys 
        355                 360                 365             


Val Leu Ala Glu Gly Gln Arg Ile Leu Thr Lys Ser Cys Arg Glu Cys 
    370                 375                 380                 


Arg Gly Gly Val Leu Val Lys Ile Thr Glu Met Cys Pro Pro Leu Asn 
385                 390                 395                 400 


Cys Ser Glu Lys Asp His Ile Leu Pro Glu Asn Gln Cys Cys Arg Val 
                405                 410                 415     


Cys Arg Gly His Asn Phe Cys Ala Glu Gly Pro Lys Cys Gly Glu Asn 
            420                 425                 430         


Ser Glu Cys Lys Asn Trp Asn Thr Lys Ala Thr Cys Glu Cys Lys Ser 
        435                 440                 445             


Gly Tyr Ile Ser Val Gln Gly Asp Ser Ala Tyr Cys Glu Asp Ile Asp 
    450                 455                 460                 


Glu Cys Ala Ala Lys Met His Tyr Cys His Ala Asn Thr Val Cys Val 
465                 470                 475                 480 


Asn Leu Pro Gly Leu Tyr Arg Cys Asp Cys Val Pro Gly Tyr Ile Arg 
                485                 490                 495     


Val Asp Asp Phe Ser Cys Thr Glu His Asp Glu Cys Gly Ser Gly Gln 
            500                 505                 510         


His Asn Cys Asp Glu Asn Ala Ile Cys Thr Asn Thr Val Gln Gly His 
        515                 520                 525             


Ser Cys Thr Cys Lys Pro Gly Tyr Val Gly Asn Gly Thr Ile Cys Arg 
    530                 535                 540                 


Ala Phe Cys Glu Glu Gly Cys Arg Tyr Gly Gly Thr Cys Val Ala Pro 
545                 550                 555                 560 


Asn Lys Cys Val Cys Pro Ser Gly Phe Thr Gly Ser His Cys Glu Lys 
                565                 570                 575     


Asp Ile Asp Glu Cys Ser Glu Gly Ile Ile Glu Cys His Asn His Ser 
            580                 585                 590         


Arg Cys Val Asn Leu Pro Gly Trp Tyr His Cys Glu Cys Arg Ser Gly 
        595                 600                 605             


Phe His Asp Asp Gly Thr Tyr Ser Leu Ser Gly Glu Ser Cys Ile Asp 
    610                 615                 620                 


Ile Asp Glu Cys Ala Leu Arg Thr His Thr Cys Trp Asn Asp Ser Ala 
625                 630                 635                 640 


Cys Ile Asn Leu Ala Gly Gly Phe Asp Cys Leu Cys Pro Ser Gly Pro 
                645                 650                 655     


Ser Cys Ser Gly Asp Cys Pro His Glu Gly Gly Leu Lys His Asn Gly 
            660                 665                 670         


Gln Val Trp Thr Leu Lys Glu Asp Arg Cys Ser Val Cys Ser Cys Lys 
        675                 680                 685             


Asp Gly Lys Ile Phe Cys Arg Arg Thr Ala Cys Asp Cys Gln Asn Pro 
    690                 695                 700                 


Ser Ala Asp Leu Phe Cys Cys Pro Glu Cys Asp Thr Arg Val Thr Ser 
705                 710                 715                 720 


Gln Cys Leu Asp Gln Asn Gly His Lys Leu Tyr Arg Ser Gly Asp Asn 
                725                 730                 735     


Trp Thr His Ser Cys Gln Gln Cys Arg Cys Leu Glu Gly Glu Val Asp 
            740                 745                 750         


Cys Trp Pro Leu Thr Cys Pro Asn Leu Ser Cys Glu Tyr Thr Ala Ile 
        755                 760                 765             


Leu Glu Gly Glu Cys Cys Pro Arg Cys Val Ser Asp Pro Cys Leu Ala 
    770                 775                 780                 


Asp Asn Ile Thr Tyr Asp Ile Arg Lys Thr Cys Leu Asp Ser Tyr Gly 
785                 790                 795                 800 


Val Ser Arg Leu Ser Gly Ser Val Trp Thr Met Ala Gly Ser Pro Cys 
                805                 810                 815     


Thr Thr Cys Lys Cys Lys Asn Gly Arg Val Cys Cys Ser Val Asp Phe 
            820                 825                 830         


Glu Cys Leu Gln Asn Asn 
        835             


<210>  9290
<211>  753
<212>  PRT
<213>  Homo Sapiens

<400>  9290

Met Pro Met Asp Leu Ile Leu Val Val Trp Phe Cys Val Cys Thr Ala 
1               5                   10                  15      


Arg Thr Val Val Gly Phe Gly Met Asp Pro Asp Leu Gln Met Asp Ile 
            20                  25                  30          


Val Thr Glu Leu Asp Leu Val Asn Thr Thr Leu Gly Val Ala Gln Val 
        35                  40                  45              


Ser Gly Met His Asn Ala Ser Lys Ala Phe Leu Phe Gln Asp Ile Glu 
    50                  55                  60                  


Arg Glu Ile His Ala Ala Pro His Val Ser Glu Lys Leu Ile Gln Leu 
65                  70                  75                  80  


Phe Arg Asn Lys Ser Glu Phe Thr Ile Leu Ala Thr Val Gln Gln Lys 
                85                  90                  95      


Pro Ser Thr Ser Gly Val Ile Leu Ser Ile Arg Glu Leu Glu His Arg 
            100                 105                 110         


Ile Tyr Glu Arg Val Ile Asp Pro Pro Asp Thr Asn Leu Pro Pro Gly 
        115                 120                 125             


Ile Asn Leu Trp Leu Gly Gln Arg Asn Gln Lys His Gly Leu Phe Lys 
    130                 135                 140                 


Gly Ile Ile Gln Asp Gly Lys Ile Ile Phe Met Pro Asn Gly Tyr Ile 
145                 150                 155                 160 


Thr Gln Cys Pro Asn Leu Asn His Thr Cys Pro Thr Cys Ser Asp Phe 
                165                 170                 175     


Leu Ser Leu Val Gln Gly Ile Met Asp Leu Gln Glu Leu Leu Ala Lys 
            180                 185                 190         


Met Thr Ala Lys Leu Asn Tyr Ala Glu Thr Arg Leu Ser Gln Leu Glu 
        195                 200                 205             


Asn Cys His Cys Glu Lys Thr Cys Gln Val Ser Gly Leu Leu Tyr Arg 
    210                 215                 220                 


Asp Gln Asp Ser Trp Val Asp Gly Asp His Cys Arg Asn Cys Thr Cys 
225                 230                 235                 240 


Lys Ser Gly Ala Val Glu Cys Arg Arg Met Ser Cys Pro Pro Leu Asn 
                245                 250                 255     


Cys Ser Pro Asp Ser Leu Pro Val His Ile Ala Gly Gln Cys Cys Lys 
            260                 265                 270         


Val Cys Arg Pro Lys Cys Ile Tyr Gly Gly Lys Val Leu Ala Glu Gly 
        275                 280                 285             


Gln Arg Ile Leu Thr Lys Ser Cys Arg Glu Cys Arg Gly Gly Val Leu 
    290                 295                 300                 


Val Lys Ile Thr Glu Met Cys Pro Pro Leu Asn Cys Ser Glu Lys Asp 
305                 310                 315                 320 


His Ile Leu Pro Glu Asn Gln Cys Cys Arg Val Cys Arg Gly His Asn 
                325                 330                 335     


Phe Cys Ala Glu Gly Pro Lys Cys Gly Glu Asn Ser Glu Cys Lys Asn 
            340                 345                 350         


Trp Asn Thr Lys Ala Thr Cys Glu Cys Lys Ser Gly Tyr Ile Ser Val 
        355                 360                 365             


Gln Gly Asp Ser Ala Tyr Cys Glu Asp Ile Asp Glu Cys Ala Ala Lys 
    370                 375                 380                 


Met His Tyr Cys His Ala Asn Thr Val Cys Val Asn Leu Pro Gly Leu 
385                 390                 395                 400 


Tyr Arg Cys Asp Cys Val Pro Gly Tyr Ile Arg Val Asp Asp Phe Ser 
                405                 410                 415     


Cys Thr Glu His Asp Glu Cys Gly Ser Gly Gln His Asn Cys Asp Glu 
            420                 425                 430         


Asn Ala Ile Cys Thr Asn Thr Val Gln Gly His Ser Cys Thr Cys Lys 
        435                 440                 445             


Pro Gly Tyr Val Gly Asn Gly Thr Ile Cys Arg Ala Phe Cys Glu Glu 
    450                 455                 460                 


Gly Cys Arg Tyr Gly Gly Thr Cys Val Ala Pro Asn Lys Cys Val Cys 
465                 470                 475                 480 


Pro Ser Gly Phe Thr Gly Ser His Cys Glu Lys Asp Ile Asp Glu Cys 
                485                 490                 495     


Ser Glu Gly Ile Ile Glu Cys His Asn His Ser Arg Cys Val Asn Leu 
            500                 505                 510         


Pro Gly Trp Tyr His Cys Glu Cys Arg Ser Gly Phe His Asp Asp Gly 
        515                 520                 525             


Thr Tyr Ser Leu Ser Gly Glu Ser Cys Ile Asp Ile Asp Glu Cys Ala 
    530                 535                 540                 


Leu Arg Thr His Thr Cys Trp Asn Asp Ser Ala Cys Ile Asn Leu Ala 
545                 550                 555                 560 


Gly Gly Phe Asp Cys Leu Cys Pro Ser Gly Pro Ser Cys Ser Gly Asp 
                565                 570                 575     


Cys Pro His Glu Gly Gly Leu Lys His Asn Gly Gln Val Trp Thr Leu 
            580                 585                 590         


Lys Glu Asp Arg Cys Ser Val Cys Ser Cys Lys Asp Gly Lys Ile Phe 
        595                 600                 605             


Cys Arg Arg Thr Ala Cys Asp Cys Gln Asn Pro Ser Ala Asp Leu Phe 
    610                 615                 620                 


Cys Cys Pro Glu Cys Asp Thr Arg Val Thr Ser Gln Cys Leu Asp Gln 
625                 630                 635                 640 


Asn Gly His Lys Leu Tyr Arg Ser Gly Asp Asn Trp Thr His Ser Cys 
                645                 650                 655     


Gln Gln Cys Arg Cys Leu Glu Gly Glu Val Asp Cys Trp Pro Leu Thr 
            660                 665                 670         


Cys Pro Asn Leu Ser Cys Glu Tyr Thr Ala Ile Leu Glu Gly Glu Cys 
        675                 680                 685             


Cys Pro Arg Cys Val Ser Asp Pro Cys Leu Ala Asp Asn Ile Thr Tyr 
    690                 695                 700                 


Asp Ile Arg Lys Thr Cys Leu Asp Ser Tyr Gly Val Ser Arg Leu Ser 
705                 710                 715                 720 


Gly Ser Val Trp Thr Met Ala Gly Ser Pro Cys Thr Thr Cys Lys Cys 
                725                 730                 735     


Lys Asn Gly Arg Val Cys Cys Ser Val Asp Phe Glu Cys Leu Gln Asn 
            740                 745                 750         


Asn 
    


<210>  9291
<211>  810
<212>  PRT
<213>  Homo Sapiens

<400>  9291

Met Pro Met Asp Leu Ile Leu Val Val Trp Phe Cys Val Cys Thr Ala 
1               5                   10                  15      


Arg Thr Val Val Gly Phe Gly Met Asp Pro Asp Leu Gln Met Asp Ile 
            20                  25                  30          


Val Thr Glu Leu Asp Leu Val Asn Thr Thr Leu Gly Val Ala Gln Val 
        35                  40                  45              


Ser Gly Met His Asn Ala Ser Lys Ala Phe Leu Phe Gln Asp Ile Glu 
    50                  55                  60                  


Arg Glu Ile His Ala Ala Pro His Val Ser Glu Lys Leu Ile Gln Leu 
65                  70                  75                  80  


Phe Arg Asn Lys Ser Glu Phe Thr Ile Leu Ala Thr Val Gln Gln Lys 
                85                  90                  95      


Pro Ser Thr Ser Gly Val Ile Leu Ser Ile Arg Glu Leu Glu His Ser 
            100                 105                 110         


Tyr Phe Glu Leu Glu Ser Ser Gly Leu Arg Asp Glu Ile Arg Tyr His 
        115                 120                 125             


Tyr Ile His Asn Gly Lys Pro Arg Thr Glu Ala Leu Pro Tyr Arg Met 
    130                 135                 140                 


Ala Asp Gly Gln Trp His Lys Val Ala Leu Ser Val Ser Ala Ser His 
145                 150                 155                 160 


Leu Leu Leu His Val Asp Cys Asn Arg Ile Tyr Glu Arg Val Ile Asp 
                165                 170                 175     


Pro Pro Asp Thr Asn Leu Pro Pro Gly Ile Asn Leu Trp Leu Gly Gln 
            180                 185                 190         


Arg Asn Gln Lys His Gly Leu Phe Lys Gly Ile Ile Gln Asp Gly Lys 
        195                 200                 205             


Ile Ile Phe Met Pro Asn Gly Tyr Ile Thr Gln Cys Pro Asn Leu Asn 
    210                 215                 220                 


His Thr Cys Pro Thr Cys Ser Asp Phe Leu Ser Leu Val Gln Gly Ile 
225                 230                 235                 240 


Met Asp Leu Gln Glu Leu Leu Ala Lys Met Thr Ala Lys Leu Asn Tyr 
                245                 250                 255     


Ala Glu Thr Arg Leu Ser Gln Leu Glu Asn Cys His Cys Glu Lys Thr 
            260                 265                 270         


Cys Gln Val Ser Gly Leu Leu Tyr Arg Asp Gln Asp Ser Trp Val Asp 
        275                 280                 285             


Gly Asp His Cys Arg Asn Cys Thr Cys Lys Ser Gly Ala Val Glu Cys 
    290                 295                 300                 


Arg Arg Met Ser Cys Pro Pro Leu Asn Cys Ser Pro Asp Ser Leu Pro 
305                 310                 315                 320 


Val His Ile Ala Gly Gln Cys Cys Lys Val Cys Arg Pro Lys Cys Ile 
                325                 330                 335     


Tyr Gly Gly Lys Val Leu Ala Glu Gly Gln Arg Ile Leu Thr Lys Ser 
            340                 345                 350         


Cys Arg Glu Cys Arg Gly Gly Val Leu Val Lys Ile Thr Glu Met Cys 
        355                 360                 365             


Pro Pro Leu Asn Cys Ser Glu Lys Asp His Ile Leu Pro Glu Asn Gln 
    370                 375                 380                 


Cys Cys Arg Val Cys Arg Gly His Asn Phe Cys Ala Glu Gly Pro Lys 
385                 390                 395                 400 


Cys Gly Glu Asn Ser Glu Cys Lys Asn Trp Asn Thr Lys Ala Thr Cys 
                405                 410                 415     


Glu Cys Lys Ser Gly Tyr Ile Ser Val Gln Gly Asp Ser Ala Tyr Cys 
            420                 425                 430         


Glu Asp Ile Asp Glu Cys Ala Ala Lys Met His Tyr Cys His Ala Asn 
        435                 440                 445             


Thr Val Cys Val Asn Leu Pro Gly Leu Tyr Arg Cys Asp Cys Val Pro 
    450                 455                 460                 


Gly Tyr Ile Arg Val Asp Asp Phe Ser Cys Thr Glu His Asp Glu Cys 
465                 470                 475                 480 


Gly Ser Gly Gln His Asn Cys Asp Glu Asn Ala Ile Cys Thr Asn Thr 
                485                 490                 495     


Val Gln Gly His Ser Cys Thr Cys Lys Pro Gly Tyr Val Gly Asn Gly 
            500                 505                 510         


Thr Ile Cys Arg Ala Phe Cys Glu Glu Gly Cys Arg Tyr Gly Gly Thr 
        515                 520                 525             


Cys Val Ala Pro Asn Lys Cys Val Cys Pro Ser Gly Phe Thr Gly Ser 
    530                 535                 540                 


His Cys Glu Lys Asp Ile Asp Glu Cys Ser Glu Gly Ile Ile Glu Cys 
545                 550                 555                 560 


His Asn His Ser Arg Cys Val Asn Leu Pro Gly Trp Tyr His Cys Glu 
                565                 570                 575     


Cys Arg Ser Gly Phe His Asp Asp Gly Thr Tyr Ser Leu Ser Gly Glu 
            580                 585                 590         


Ser Cys Ile Asp Ile Asp Glu Cys Ala Leu Arg Thr His Thr Cys Trp 
        595                 600                 605             


Asn Asp Ser Ala Cys Ile Asn Leu Ala Gly Gly Phe Asp Cys Leu Cys 
    610                 615                 620                 


Pro Ser Gly Pro Ser Cys Ser Gly Asp Cys Pro His Glu Gly Gly Leu 
625                 630                 635                 640 


Lys His Asn Gly Gln Val Trp Thr Leu Lys Glu Asp Arg Cys Ser Val 
                645                 650                 655     


Cys Ser Cys Lys Asp Gly Lys Ile Phe Cys Arg Arg Thr Ala Cys Asp 
            660                 665                 670         


Cys Gln Asn Pro Ser Ala Asp Leu Phe Cys Cys Pro Glu Cys Asp Thr 
        675                 680                 685             


Arg Val Thr Ser Gln Cys Leu Asp Gln Asn Gly His Lys Leu Tyr Arg 
    690                 695                 700                 


Ser Gly Asp Asn Trp Thr His Ser Cys Gln Gln Cys Arg Cys Leu Glu 
705                 710                 715                 720 


Gly Glu Val Asp Cys Trp Pro Leu Thr Cys Pro Asn Leu Ser Cys Glu 
                725                 730                 735     


Tyr Thr Ala Ile Leu Glu Gly Glu Cys Cys Pro Arg Cys Val Ser Asp 
            740                 745                 750         


Pro Cys Leu Ala Asp Asn Ile Thr Tyr Asp Ile Arg Lys Thr Cys Leu 
        755                 760                 765             


Asp Ser Tyr Gly Val Ser Arg Leu Ser Gly Ser Val Trp Thr Met Ala 
    770                 775                 780                 


Gly Ser Pro Cys Thr Thr Cys Lys Cys Lys Asn Gly Arg Val Cys Cys 
785                 790                 795                 800 


Ser Val Asp Phe Glu Cys Leu Gln Asn Asn 
                805                 810 


<210>  9292
<211>  763
<212>  PRT
<213>  Homo Sapiens

<400>  9292

Met Pro Met Asp Leu Ile Leu Val Val Trp Phe Cys Val Cys Thr Ala 
1               5                   10                  15      


Arg Thr Val Val Gly Phe Gly Met Asp Pro Asp Leu Gln Met Asp Ile 
            20                  25                  30          


Val Thr Glu Leu Asp Leu Val Asn Thr Thr Leu Gly Val Ala Gln Val 
        35                  40                  45              


Ser Gly Met His Asn Ala Ser Lys Ala Phe Leu Phe Gln Asp Ile Glu 
    50                  55                  60                  


Arg Glu Ile His Ala Ala Pro His Val Ser Glu Lys Leu Ile Gln Leu 
65                  70                  75                  80  


Phe Arg Asn Lys Ser Glu Phe Thr Ile Leu Ala Thr Val Gln Gln Lys 
                85                  90                  95      


Pro Ser Thr Ser Gly Val Ile Leu Ser Ile Arg Glu Leu Glu His Ser 
            100                 105                 110         


Tyr Phe Glu Leu Glu Ser Ser Gly Leu Arg Asp Glu Ile Arg Tyr His 
        115                 120                 125             


Tyr Ile His Asn Gly Lys Pro Arg Thr Glu Ala Leu Pro Tyr Arg Met 
    130                 135                 140                 


Ala Asp Gly Gln Trp His Lys Val Ala Leu Ser Val Ser Ala Ser His 
145                 150                 155                 160 


Leu Leu Leu His Val Asp Cys Asn Arg Ile Tyr Glu Arg Val Ile Asp 
                165                 170                 175     


Pro Pro Asp Thr Asn Leu Pro Pro Gly Ile Asn Leu Trp Leu Gly Gln 
            180                 185                 190         


Arg Asn Gln Lys His Gly Leu Phe Lys Gly Ile Ile Gln Asp Gly Lys 
        195                 200                 205             


Ile Ile Phe Met Pro Asn Gly Tyr Ile Thr Gln Cys Pro Asn Leu Asn 
    210                 215                 220                 


His Thr Cys Pro Thr Cys Ser Asp Phe Leu Ser Leu Val Gln Gly Ile 
225                 230                 235                 240 


Met Asp Leu Gln Glu Leu Leu Ala Lys Met Thr Ala Lys Leu Asn Tyr 
                245                 250                 255     


Ala Glu Thr Arg Leu Ser Gln Leu Glu Asn Cys His Cys Glu Lys Thr 
            260                 265                 270         


Cys Gln Val Ser Gly Leu Leu Tyr Arg Asp Gln Asp Ser Trp Val Asp 
        275                 280                 285             


Gly Asp His Cys Arg Asn Cys Thr Cys Lys Ser Gly Ala Val Glu Cys 
    290                 295                 300                 


Arg Arg Met Ser Cys Pro Pro Leu Asn Cys Ser Pro Asp Ser Leu Pro 
305                 310                 315                 320 


Val His Ile Ala Gly Gln Cys Cys Lys Val Cys Arg Pro Lys Cys Ile 
                325                 330                 335     


Tyr Gly Gly Lys Val Leu Ala Glu Gly Gln Arg Ile Leu Thr Lys Ser 
            340                 345                 350         


Cys Arg Glu Cys Arg Gly Gly Val Leu Val Lys Ile Thr Glu Met Cys 
        355                 360                 365             


Pro Pro Leu Asn Cys Ser Glu Lys Asp His Ile Leu Pro Glu Asn Gln 
    370                 375                 380                 


Cys Cys Arg Val Cys Arg Gly His Asn Phe Cys Ala Glu Gly Pro Lys 
385                 390                 395                 400 


Cys Gly Glu Asn Ser Glu Cys Lys Asn Trp Asn Thr Lys Ala Thr Cys 
                405                 410                 415     


Glu Cys Lys Ser Gly Tyr Ile Ser Val Gln Gly Asp Ser Ala Tyr Cys 
            420                 425                 430         


Glu Asp Ile Asp Glu Cys Ala Ala Lys Met His Tyr Cys His Ala Asn 
        435                 440                 445             


Thr Val Cys Val Asn Leu Pro Gly Leu Tyr Arg Cys Asp Cys Val Pro 
    450                 455                 460                 


Gly Tyr Ile Arg Val Asp Asp Phe Ser Cys Thr Glu His Asp Glu Cys 
465                 470                 475                 480 


Gly Ser Gly Gln His Asn Cys Asp Glu Asn Ala Ile Cys Thr Asn Thr 
                485                 490                 495     


Val Gln Gly His Ser Cys Thr Cys Lys Pro Gly Tyr Val Gly Asn Gly 
            500                 505                 510         


Thr Ile Cys Arg Ala Phe Cys Glu Glu Gly Cys Arg Tyr Gly Gly Thr 
        515                 520                 525             


Cys Val Ala Pro Asn Lys Cys Val Cys Pro Ser Gly Phe Thr Gly Ser 
    530                 535                 540                 


His Cys Glu Lys Asp Ile Asp Glu Cys Ala Leu Arg Thr His Thr Cys 
545                 550                 555                 560 


Trp Asn Asp Ser Ala Cys Ile Asn Leu Ala Gly Gly Phe Asp Cys Leu 
                565                 570                 575     


Cys Pro Ser Gly Pro Ser Cys Ser Gly Asp Cys Pro His Glu Gly Gly 
            580                 585                 590         


Leu Lys His Asn Gly Gln Val Trp Thr Leu Lys Glu Asp Arg Cys Ser 
        595                 600                 605             


Val Cys Ser Cys Lys Asp Gly Lys Ile Phe Cys Arg Arg Thr Ala Cys 
    610                 615                 620                 


Asp Cys Gln Asn Pro Ser Ala Asp Leu Phe Cys Cys Pro Glu Cys Asp 
625                 630                 635                 640 


Thr Arg Val Thr Ser Gln Cys Leu Asp Gln Asn Gly His Lys Leu Tyr 
                645                 650                 655     


Arg Ser Gly Asp Asn Trp Thr His Ser Cys Gln Gln Cys Arg Cys Leu 
            660                 665                 670         


Glu Gly Glu Val Asp Cys Trp Pro Leu Thr Cys Pro Asn Leu Ser Cys 
        675                 680                 685             


Glu Tyr Thr Ala Ile Leu Glu Gly Glu Cys Cys Pro Arg Cys Val Ser 
    690                 695                 700                 


Asp Pro Cys Leu Ala Asp Asn Ile Thr Tyr Asp Ile Arg Lys Thr Cys 
705                 710                 715                 720 


Leu Asp Ser Tyr Gly Val Ser Arg Leu Ser Gly Ser Val Trp Thr Met 
                725                 730                 735     


Ala Gly Ser Pro Cys Thr Thr Cys Lys Cys Lys Asn Gly Arg Val Cys 
            740                 745                 750         


Cys Ser Val Asp Phe Glu Cys Leu Gln Asn Asn 
        755                 760             


<210>  9293
<211>  122
<212>  PRT
<213>  Homo Sapiens

<400>  9293

Cys Pro Thr Cys Asn Asp Phe His Gly Leu Val Gln Lys Ile Met Glu 
1               5                   10                  15      


Leu Gln Asp Ile Leu Ala Lys Thr Ser Ala Lys Leu Ser Arg Ala Glu 
            20                  25                  30          


Gln Arg Met Asn Arg Leu Asp Gln Cys Tyr Cys Glu Arg Thr Cys Thr 
        35                  40                  45              


Met Lys Gly Thr Thr Tyr Arg Glu Phe Glu Ser Trp Ile Asp Gly Cys 
    50                  55                  60                  


Lys Asn Cys Thr Cys Leu Asn Gly Thr Ile Gln Cys Glu Thr Leu Ile 
65                  70                  75                  80  


Cys Pro Asn Pro Asp Cys Pro Leu Lys Ser Ala Leu Ala Tyr Val Asp 
                85                  90                  95      


Gly Lys Cys Cys Lys Glu Cys Lys Cys Glu His Asn Phe Tyr Asp Glu 
            100                 105                 110         


Tyr Phe Leu Trp Lys Asn Lys Ala Leu Tyr 
        115                 120         


<210>  9294
<211>  166
<212>  PRT
<213>  Homo Sapiens

<400>  9294

Met Glu Leu Phe Leu Phe Leu Ser Pro Thr Ser Tyr Pro Ser Pro Val 
1               5                   10                  15      


Trp Gly Leu Gly Val Asp Pro Ser Leu Gln Ile Asp Val Leu Thr Glu 
            20                  25                  30          


Leu Glu Leu Gly Glu Ser Thr Thr Gly Val Arg Gln Val Pro Gly Leu 
        35                  40                  45              


His Asn Gly Thr Lys Ala Phe Leu Phe Gln Asp Thr Pro Arg Ser Ile 
    50                  55                  60                  


Lys Ala Ser Thr Ala Thr Ala Glu Gln Phe Phe Gln Lys Leu Arg Asn 
65                  70                  75                  80  


Lys His Glu Phe Thr Ile Leu Val Thr Leu Lys Gln Thr His Leu Asn 
                85                  90                  95      


Ser Gly Val Ile Leu Ser Ile His His Leu Asp His Arg Tyr Leu Glu 
            100                 105                 110         


Leu Glu Ser Ser Gly His Arg Asn Glu Val Arg Leu His Tyr Arg Ser 
        115                 120                 125             


Gly Ser His Arg Pro His Thr Glu Val Phe Pro Tyr Ile Leu Ala Asp 
    130                 135                 140                 


Asp Lys Trp His Lys Leu Ser Leu Ala Ile Ser Ala Ser His Leu Ile 
145                 150                 155                 160 


Leu His Ile Asp Cys Asn 
                165     


<210>  9295
<211>  22
<212>  PRT
<213>  Homo Sapiens

<400>  9295

Met Glu Ser Arg Val Leu Leu Arg Thr Phe Cys Leu Ile Phe Gly Leu 
1               5                   10                  15      


Gly Ala Val Trp Gly Leu 
            20          


<210>  9296
<211>  112
<212>  PRT
<213>  Homo Sapiens

<400>  9296

Met Glu Ser Arg Val Leu Leu Arg Thr Phe Cys Leu Ile Phe Gly Leu 
1               5                   10                  15      


Gly Ala Val Trp Gly Leu Gly Val Asp Pro Ser Leu Gln Ile Asp Val 
            20                  25                  30          


Leu Thr Glu Leu Glu Leu Gly Glu Ser Thr Thr Gly Val Arg Gln Val 
        35                  40                  45              


Pro Gly Leu His Asn Gly Thr Lys Ala Phe Leu Phe Gln Asp Thr Pro 
    50                  55                  60                  


Arg Ser Ile Lys Ala Ser Thr Ala Thr Ala Glu Gln Phe Phe Gln Lys 
65                  70                  75                  80  


Leu Arg Asn Lys His Glu Phe Thr Ile Leu Val Thr Leu Lys Gln Thr 
                85                  90                  95      


His Leu Asn Ser Gly Val Ile Leu Ser Ile His His Leu Asp His Arg 
            100                 105                 110         


<210>  9297
<211>  816
<212>  PRT
<213>  Homo Sapiens

<400>  9297

Met Glu Ser Arg Val Leu Leu Arg Thr Phe Cys Leu Ile Phe Gly Leu 
1               5                   10                  15      


Gly Ala Val Trp Gly Leu Gly Val Asp Pro Ser Leu Gln Ile Asp Val 
            20                  25                  30          


Leu Thr Glu Leu Glu Leu Gly Glu Ser Thr Thr Gly Val Arg Gln Val 
        35                  40                  45              


Pro Gly Leu His Asn Gly Thr Lys Ala Phe Leu Phe Gln Asp Thr Pro 
    50                  55                  60                  


Arg Ser Ile Lys Ala Ser Thr Ala Thr Ala Glu Gln Phe Phe Gln Lys 
65                  70                  75                  80  


Leu Arg Asn Lys His Glu Phe Thr Ile Leu Val Thr Leu Lys Gln Thr 
                85                  90                  95      


His Leu Asn Ser Gly Val Ile Leu Ser Ile His His Leu Asp His Arg 
            100                 105                 110         


Tyr Leu Glu Leu Glu Ser Ser Gly His Arg Asn Glu Val Arg Leu His 
        115                 120                 125             


Tyr Arg Ser Gly Ser His Arg Pro His Thr Glu Val Phe Pro Tyr Ile 
    130                 135                 140                 


Leu Ala Asp Asp Lys Trp His Lys Leu Ser Leu Ala Ile Ser Ala Ser 
145                 150                 155                 160 


His Leu Ile Leu His Ile Asp Cys Asn Lys Ile Tyr Glu Arg Val Val 
                165                 170                 175     


Glu Lys Pro Ser Thr Asp Leu Pro Leu Gly Thr Thr Phe Trp Leu Gly 
            180                 185                 190         


Gln Arg Asn Asn Ala His Gly Tyr Phe Lys Gly Ile Met Gln Asp Val 
        195                 200                 205             


Gln Leu Leu Val Met Pro Gln Gly Phe Ile Ala Gln Cys Pro Asp Leu 
    210                 215                 220                 


Asn Arg Thr Cys Pro Thr Cys Asn Asp Phe His Gly Leu Val Gln Lys 
225                 230                 235                 240 


Ile Met Glu Leu Gln Asp Ile Leu Ala Lys Thr Ser Ala Lys Leu Ser 
                245                 250                 255     


Arg Ala Glu Gln Arg Met Asn Arg Leu Asp Gln Cys Tyr Cys Glu Arg 
            260                 265                 270         


Thr Cys Thr Met Lys Gly Thr Thr Tyr Arg Glu Phe Glu Ser Trp Ile 
        275                 280                 285             


Asp Gly Cys Lys Asn Cys Thr Cys Leu Asn Gly Thr Ile Gln Cys Glu 
    290                 295                 300                 


Thr Leu Ile Cys Pro Asn Pro Asp Cys Pro Leu Lys Ser Ala Leu Ala 
305                 310                 315                 320 


Tyr Val Asp Gly Lys Cys Cys Lys Glu Cys Lys Ser Ile Cys Gln Phe 
                325                 330                 335     


Gln Gly Arg Thr Tyr Phe Glu Gly Glu Arg Asn Thr Val Tyr Ser Ser 
            340                 345                 350         


Ser Gly Val Cys Val Leu Tyr Glu Cys Lys Asp Gln Thr Met Lys Leu 
        355                 360                 365             


Val Glu Ser Ser Gly Cys Pro Ala Leu Asp Cys Pro Glu Ser His Gln 
    370                 375                 380                 


Ile Thr Leu Ser His Ser Cys Cys Lys Val Cys Lys Gly Tyr Asp Phe 
385                 390                 395                 400 


Cys Ser Glu Arg His Asn Cys Met Glu Asn Ser Ile Cys Arg Asn Leu 
                405                 410                 415     


Asn Asp Arg Ala Val Cys Ser Cys Arg Asp Gly Phe Arg Ala Leu Arg 
            420                 425                 430         


Glu Asp Asn Ala Tyr Cys Glu Asp Ile Asp Glu Cys Ala Glu Gly Arg 
        435                 440                 445             


His Tyr Cys Arg Glu Asn Thr Met Cys Val Asn Thr Pro Gly Ser Phe 
    450                 455                 460                 


Met Cys Ile Cys Lys Thr Gly Tyr Ile Arg Ile Asp Asp Tyr Ser Cys 
465                 470                 475                 480 


Thr Glu His Asp Glu Cys Ile Thr Asn Gln His Asn Cys Asp Glu Asn 
                485                 490                 495     


Ala Leu Cys Phe Asn Thr Val Gly Gly His Asn Cys Val Cys Lys Pro 
            500                 505                 510         


Gly Tyr Thr Gly Asn Gly Thr Thr Cys Lys Ala Phe Cys Lys Asp Gly 
        515                 520                 525             


Cys Arg Asn Gly Gly Ala Cys Ile Ala Ala Asn Val Cys Ala Cys Pro 
    530                 535                 540                 


Gln Gly Phe Thr Gly Pro Ser Cys Glu Thr Asp Ile Asp Glu Cys Ser 
545                 550                 555                 560 


Asp Gly Phe Val Gln Cys Asp Ser Arg Ala Asn Cys Ile Asn Leu Pro 
                565                 570                 575     


Gly Trp Tyr His Cys Glu Cys Arg Asp Gly Tyr His Asp Asn Gly Met 
            580                 585                 590         


Phe Ser Pro Ser Gly Glu Ser Cys Glu Asp Ile Asp Glu Cys Gly Thr 
        595                 600                 605             


Gly Arg His Ser Cys Ala Asn Asp Thr Ile Cys Phe Asn Leu Asp Gly 
    610                 615                 620                 


Gly Tyr Asp Cys Arg Cys Pro His Gly Lys Asn Cys Thr Gly Asp Cys 
625                 630                 635                 640 


Ile His Asp Gly Lys Val Lys His Asn Gly Gln Ile Trp Val Leu Glu 
                645                 650                 655     


Asn Asp Arg Cys Ser Val Cys Ser Cys Gln Asn Gly Phe Val Met Cys 
            660                 665                 670         


Arg Arg Met Val Cys Asp Cys Glu Asn Pro Thr Val Asp Leu Phe Cys 
        675                 680                 685             


Cys Pro Glu Cys Asp Pro Arg Leu Ser Ser Gln Cys Leu His Gln Asn 
    690                 695                 700                 


Gly Glu Thr Leu Tyr Asn Ser Gly Asp Thr Trp Val Gln Asn Cys Gln 
705                 710                 715                 720 


Gln Cys Arg Cys Leu Gln Gly Glu Val Asp Cys Trp Pro Leu Pro Cys 
                725                 730                 735     


Pro Asp Val Glu Cys Glu Phe Ser Ile Leu Pro Glu Asn Glu Cys Cys 
            740                 745                 750         


Pro Arg Cys Val Thr Asp Pro Cys Gln Ala Asp Thr Ile Arg Asn Asp 
        755                 760                 765             


Ile Thr Lys Thr Cys Leu Asp Glu Met Asn Val Val Arg Phe Thr Gly 
    770                 775                 780                 


Ser Ser Trp Ile Lys His Gly Thr Glu Cys Thr Leu Cys Gln Cys Lys 
785                 790                 795                 800 


Asn Gly His Ile Cys Cys Ser Val Asp Pro Gln Cys Leu Gln Glu Leu 
                805                 810                 815     


<210>  9298
<211>  816
<212>  PRT
<213>  Homo Sapiens

<400>  9298

Met Glu Ser Arg Val Leu Leu Arg Thr Phe Cys Leu Ile Phe Gly Leu 
1               5                   10                  15      


Gly Ala Val Trp Gly Leu Gly Val Asp Pro Ser Leu Gln Ile Asp Val 
            20                  25                  30          


Leu Thr Glu Leu Glu Leu Gly Glu Ser Thr Thr Gly Val Arg Gln Val 
        35                  40                  45              


Pro Gly Leu His Asn Gly Thr Lys Ala Phe Leu Phe Gln Asp Thr Pro 
    50                  55                  60                  


Arg Ser Ile Lys Ala Ser Thr Ala Thr Ala Glu Gln Phe Phe Gln Lys 
65                  70                  75                  80  


Leu Arg Asn Lys His Glu Phe Thr Ile Leu Val Thr Leu Lys Gln Thr 
                85                  90                  95      


His Leu Asn Ser Gly Val Ile Leu Ser Ile His His Leu Asp His Arg 
            100                 105                 110         


Tyr Leu Glu Leu Glu Ser Ser Gly His Arg Asn Glu Val Arg Leu His 
        115                 120                 125             


Tyr Arg Ser Gly Ser His Arg Pro His Thr Glu Val Phe Pro Tyr Ile 
    130                 135                 140                 


Leu Ala Asp Asp Lys Trp His Lys Leu Ser Leu Ala Ile Ser Ala Ser 
145                 150                 155                 160 


His Leu Ile Leu His Ile Asp Cys Asn Lys Ile Tyr Glu Arg Val Val 
                165                 170                 175     


Glu Lys Pro Ser Thr Asp Leu Pro Leu Gly Thr Thr Phe Trp Leu Gly 
            180                 185                 190         


Gln Arg Asn Asn Ala His Gly Tyr Phe Lys Gly Ile Met Gln Asp Val 
        195                 200                 205             


Gln Leu Leu Val Met Pro Gln Gly Phe Ile Ala Gln Cys Pro Asp Leu 
    210                 215                 220                 


Asn Arg Thr Cys Pro Thr Cys Asn Asp Phe His Gly Leu Val Gln Lys 
225                 230                 235                 240 


Ile Met Glu Leu Gln Asp Ile Leu Ala Lys Thr Ser Ala Lys Leu Ser 
                245                 250                 255     


Arg Ala Glu Gln Arg Met Asn Arg Leu Asp Gln Cys Tyr Cys Glu Arg 
            260                 265                 270         


Thr Cys Thr Met Lys Gly Thr Thr Tyr Arg Glu Phe Glu Ser Trp Ile 
        275                 280                 285             


Asp Gly Cys Lys Asn Cys Thr Cys Leu Asn Gly Thr Ile Gln Cys Glu 
    290                 295                 300                 


Thr Leu Ile Cys Pro Asn Pro Asp Cys Pro Leu Lys Ser Ala Leu Ala 
305                 310                 315                 320 


Tyr Val Asp Gly Lys Cys Cys Lys Glu Cys Lys Ser Ile Cys Gln Phe 
                325                 330                 335     


Gln Gly Arg Thr Tyr Phe Glu Gly Glu Arg Asn Thr Val Tyr Ser Ser 
            340                 345                 350         


Ser Gly Val Cys Val Leu Tyr Glu Cys Lys Asp Gln Thr Met Lys Leu 
        355                 360                 365             


Val Glu Ser Ser Gly Cys Pro Ala Leu Asp Cys Pro Glu Ser His Gln 
    370                 375                 380                 


Ile Thr Leu Ser His Ser Cys Cys Lys Val Cys Lys Gly Tyr Asp Phe 
385                 390                 395                 400 


Cys Ser Glu Arg His Asn Cys Met Glu Asn Ser Ile Cys Arg Asn Leu 
                405                 410                 415     


Asn Asp Arg Ala Val Cys Ser Cys Arg Asp Gly Phe Arg Ala Leu Arg 
            420                 425                 430         


Glu Asp Asn Ala Tyr Cys Glu Asp Ile Asp Glu Cys Ala Glu Gly Arg 
        435                 440                 445             


His Tyr Cys Arg Glu Asn Thr Met Cys Val Asn Thr Pro Gly Ser Phe 
    450                 455                 460                 


Met Cys Ile Cys Lys Thr Gly Tyr Ile Arg Ile Asp Asp Tyr Ser Cys 
465                 470                 475                 480 


Thr Glu His Asp Glu Cys Ile Thr Asn Gln His Asn Cys Asp Glu Asn 
                485                 490                 495     


Ala Leu Cys Phe Asn Thr Val Gly Gly His Asn Cys Val Cys Lys Pro 
            500                 505                 510         


Gly Tyr Thr Gly Asn Gly Thr Thr Cys Lys Ala Phe Cys Lys Asp Gly 
        515                 520                 525             


Cys Arg Asn Gly Gly Ala Cys Ile Ala Ala Asn Val Cys Ala Cys Pro 
    530                 535                 540                 


Gln Gly Phe Thr Gly Pro Ser Cys Glu Thr Asp Ile Asp Glu Cys Ser 
545                 550                 555                 560 


Asp Gly Phe Val Gln Cys Asp Ser Arg Ala Asn Cys Ile Asn Leu Pro 
                565                 570                 575     


Gly Trp Tyr His Cys Glu Cys Arg Asp Gly Tyr His Asp Asn Gly Met 
            580                 585                 590         


Phe Ser Pro Ser Gly Glu Ser Cys Glu Asp Ile Asp Glu Cys Gly Thr 
        595                 600                 605             


Gly Arg His Ser Cys Ala Asn Asp Thr Ile Cys Phe Asn Leu Asp Gly 
    610                 615                 620                 


Gly Tyr Asp Cys Arg Cys Pro His Gly Lys Asn Cys Thr Gly Asp Cys 
625                 630                 635                 640 


Ile His Asp Gly Lys Val Lys His Asn Gly Gln Ile Trp Val Leu Glu 
                645                 650                 655     


Asn Asp Arg Cys Ser Val Cys Ser Cys Gln Asn Gly Phe Val Met Cys 
            660                 665                 670         


Arg Arg Met Val Cys Asp Cys Glu Asn Pro Thr Val Asp Leu Phe Cys 
        675                 680                 685             


Cys Pro Glu Cys Asp Pro Arg Leu Ser Ser Gln Cys Leu His Gln Asn 
    690                 695                 700                 


Gly Glu Thr Leu Tyr Asn Ser Gly Asp Thr Trp Val Gln Asn Cys Gln 
705                 710                 715                 720 


Gln Cys Arg Cys Leu Gln Gly Glu Val Asp Cys Trp Pro Leu Pro Cys 
                725                 730                 735     


Pro Asp Val Glu Cys Glu Phe Ser Ile Leu Pro Glu Asn Glu Cys Cys 
            740                 745                 750         


Pro Arg Cys Val Thr Asp Pro Cys Gln Ala Asp Thr Ile Arg Asn Asp 
        755                 760                 765             


Ile Thr Lys Thr Cys Leu Asp Glu Met Asn Val Val Arg Phe Thr Gly 
    770                 775                 780                 


Ser Ser Trp Ile Lys His Gly Thr Glu Cys Thr Leu Cys Gln Cys Lys 
785                 790                 795                 800 


Asn Gly His Ile Cys Cys Ser Val Asp Pro Gln Cys Leu Gln Glu Leu 
                805                 810                 815     


<210>  9299
<211>  321
<212>  PRT
<213>  Homo Sapiens

<400>  9299

Met Glu Ser Arg Val Leu Leu Arg Thr Phe Cys Leu Ile Phe Gly Leu 
1               5                   10                  15      


Gly Ala Val Trp Gly Leu Gly Val Asp Pro Ser Leu Gln Ile Asp Val 
            20                  25                  30          


Leu Thr Glu Leu Glu Leu Gly Glu Ser Thr Thr Gly Val Arg Gln Val 
        35                  40                  45              


Pro Gly Leu His Asn Gly Thr Lys Ala Phe Leu Phe Gln Asp Thr Pro 
    50                  55                  60                  


Arg Ser Ile Lys Ala Ser Thr Ala Thr Ala Glu Gln Phe Phe Gln Lys 
65                  70                  75                  80  


Leu Arg Asn Lys His Glu Phe Thr Ile Leu Val Thr Leu Lys Gln Thr 
                85                  90                  95      


His Leu Asn Ser Gly Val Ile Leu Ser Ile His His Leu Asp His Arg 
            100                 105                 110         


Tyr Leu Glu Leu Glu Ser Ser Gly His Arg Asn Glu Val Arg Leu His 
        115                 120                 125             


Tyr Arg Ser Gly Ser His Arg Pro His Thr Glu Val Phe Pro Tyr Ile 
    130                 135                 140                 


Leu Ala Asp Asp Lys Trp His Lys Leu Ser Leu Ala Ile Ser Ala Ser 
145                 150                 155                 160 


His Leu Ile Leu His Ile Asp Cys Asn Lys Ile Tyr Glu Arg Val Val 
                165                 170                 175     


Glu Lys Pro Ser Thr Asp Leu Pro Leu Gly Thr Thr Phe Trp Leu Gly 
            180                 185                 190         


Gln Arg Asn Asn Ala His Gly Tyr Phe Lys Gly Ile Met Gln Asp Val 
        195                 200                 205             


Gln Leu Leu Val Met Pro Gln Gly Phe Ile Ala Gln Cys Pro Asp Leu 
    210                 215                 220                 


Asn Arg Thr Cys Pro Thr Cys Asn Asp Phe His Gly Leu Val Gln Lys 
225                 230                 235                 240 


Ile Met Glu Leu Gln Asp Ile Leu Ala Lys Thr Ser Ala Lys Leu Ser 
                245                 250                 255     


Arg Ala Glu Gln Arg Met Asn Arg Leu Asp Gln Cys Tyr Cys Glu Arg 
            260                 265                 270         


Thr Cys Thr Met Lys Gly Thr Thr Tyr Arg Glu Phe Glu Ser Trp Ile 
        275                 280                 285             


Asp Gly Cys Lys Asn Cys Thr Cys Leu Asn Gly Thr Ile Gln Cys Glu 
    290                 295                 300                 


Thr Leu Ile Cys Pro Asn Pro Asp Cys Pro Leu Lys Ser Ala Leu Ala 
305                 310                 315                 320 


Tyr 
    


<210>  9300
<211>  110
<212>  PRT
<213>  Homo Sapiens

<400>  9300

Met Glu Thr Gly Leu Gly Ala Pro Leu Phe Lys Ala Trp Leu Leu Ile 
1               5                   10                  15      


Ser Val Trp Gly Leu Gly Val Asp Pro Ser Leu Gln Ile Asp Val Leu 
            20                  25                  30          


Thr Glu Leu Glu Leu Gly Glu Ser Thr Thr Gly Val Arg Gln Val Pro 
        35                  40                  45              


Gly Leu His Asn Gly Thr Lys Ala Phe Leu Phe Gln Asp Thr Pro Arg 
    50                  55                  60                  


Ser Ile Lys Ala Ser Thr Ala Thr Ala Glu Gln Phe Phe Gln Lys Leu 
65                  70                  75                  80  


Arg Asn Lys His Glu Phe Thr Ile Leu Val Thr Leu Lys Gln Thr His 
                85                  90                  95      


Leu Asn Ser Gly Val Ile Leu Ser Ile His His Leu Asp His 
            100                 105                 110 


<210>  9301
<211>  815
<212>  PRT
<213>  Homo Sapiens

<400>  9301

Met Glu Thr Gly Leu Gly Ala Pro Leu Phe Lys Ala Trp Leu Leu Ile 
1               5                   10                  15      


Ser Val Trp Gly Leu Gly Val Asp Pro Ser Leu Gln Ile Asp Val Leu 
            20                  25                  30          


Thr Glu Leu Glu Leu Gly Glu Ser Thr Thr Gly Val Arg Gln Val Pro 
        35                  40                  45              


Gly Leu His Asn Gly Thr Lys Ala Phe Leu Phe Gln Asp Thr Pro Arg 
    50                  55                  60                  


Ser Ile Lys Ala Ser Thr Ala Thr Ala Glu Gln Phe Phe Gln Lys Leu 
65                  70                  75                  80  


Arg Asn Lys His Glu Phe Thr Ile Leu Val Thr Leu Lys Gln Thr His 
                85                  90                  95      


Leu Asn Ser Gly Val Ile Leu Ser Ile His His Leu Asp His Arg Tyr 
            100                 105                 110         


Leu Glu Leu Glu Ser Ser Gly His Arg Asn Glu Val Arg Leu His Tyr 
        115                 120                 125             


Arg Ser Gly Ser His Arg Pro His Thr Glu Val Phe Pro Tyr Ile Leu 
    130                 135                 140                 


Ala Asp Asp Lys Trp His Lys Leu Ser Leu Ala Ile Ser Ala Ser His 
145                 150                 155                 160 


Leu Ile Leu His Ile Asp Cys Asn Lys Ile Tyr Glu Arg Val Val Glu 
                165                 170                 175     


Lys Pro Ser Thr Asp Leu Pro Leu Gly Thr Thr Phe Trp Leu Gly Gln 
            180                 185                 190         


Arg Asn Asn Ala His Gly Tyr Phe Lys Gly Ile Met Gln Asp Val Gln 
        195                 200                 205             


Leu Leu Val Met Pro Gln Gly Phe Ile Ala Gln Cys Pro Asp Leu Asn 
    210                 215                 220                 


Arg Thr Cys Pro Thr Cys Asn Asp Phe His Gly Leu Val Gln Lys Ile 
225                 230                 235                 240 


Met Glu Leu Gln Asp Ile Leu Ala Lys Thr Ser Ala Lys Leu Ser Arg 
                245                 250                 255     


Ala Glu Gln Arg Met Asn Arg Leu Asp Gln Cys Tyr Cys Glu Arg Thr 
            260                 265                 270         


Cys Thr Met Lys Gly Thr Thr Tyr Arg Glu Phe Glu Ser Trp Ile Asp 
        275                 280                 285             


Gly Cys Lys Asn Cys Thr Cys Leu Asn Gly Thr Ile Gln Cys Glu Thr 
    290                 295                 300                 


Leu Ile Cys Pro Asn Pro Asp Cys Pro Leu Lys Ser Ala Leu Ala Tyr 
305                 310                 315                 320 


Val Asp Gly Lys Cys Cys Lys Glu Cys Lys Ser Ile Cys Gln Phe Gln 
                325                 330                 335     


Gly Arg Thr Tyr Phe Glu Gly Glu Arg Asn Thr Val Tyr Ser Ser Ser 
            340                 345                 350         


Gly Val Cys Val Leu Tyr Glu Cys Lys Asp Gln Thr Met Lys Leu Val 
        355                 360                 365             


Glu Ser Ser Gly Cys Pro Ala Leu Asp Cys Pro Glu Ser His Gln Ile 
    370                 375                 380                 


Thr Leu Ser His Ser Cys Cys Lys Val Cys Lys Gly Tyr Asp Phe Cys 
385                 390                 395                 400 


Ser Glu Arg His Asn Cys Met Glu Asn Ser Ile Cys Arg Asn Leu Asn 
                405                 410                 415     


Asp Arg Ala Val Cys Ser Cys Arg Asp Gly Phe Arg Ala Leu Arg Glu 
            420                 425                 430         


Asp Asn Ala Tyr Cys Glu Asp Ile Asp Glu Cys Ala Glu Gly Arg His 
        435                 440                 445             


Tyr Cys Arg Glu Asn Thr Met Cys Val Asn Thr Pro Gly Ser Phe Met 
    450                 455                 460                 


Cys Ile Cys Lys Thr Gly Tyr Ile Arg Ile Asp Asp Tyr Ser Cys Thr 
465                 470                 475                 480 


Glu His Asp Glu Cys Ile Thr Asn Gln His Asn Cys Asp Glu Asn Ala 
                485                 490                 495     


Leu Cys Phe Asn Thr Val Gly Gly His Asn Cys Val Cys Lys Pro Gly 
            500                 505                 510         


Tyr Thr Gly Asn Gly Thr Thr Cys Lys Ala Phe Cys Lys Asp Gly Cys 
        515                 520                 525             


Arg Asn Gly Gly Ala Cys Ile Ala Ala Asn Val Cys Ala Cys Pro Gln 
    530                 535                 540                 


Gly Phe Thr Gly Pro Ser Cys Glu Thr Asp Ile Asp Glu Cys Ser Asp 
545                 550                 555                 560 


Gly Phe Val Gln Cys Asp Ser Arg Ala Asn Cys Ile Asn Leu Pro Gly 
                565                 570                 575     


Trp Tyr His Cys Glu Cys Arg Asp Gly Tyr His Asp Asn Gly Met Phe 
            580                 585                 590         


Ser Pro Ser Gly Glu Ser Cys Glu Asp Ile Asp Glu Cys Gly Thr Gly 
        595                 600                 605             


Arg His Ser Cys Ala Asn Asp Thr Ile Cys Phe Asn Leu Asp Gly Gly 
    610                 615                 620                 


Tyr Asp Cys Arg Cys Pro His Gly Lys Asn Cys Thr Gly Asp Cys Ile 
625                 630                 635                 640 


His Asp Gly Lys Val Lys His Asn Gly Gln Ile Trp Val Leu Glu Asn 
                645                 650                 655     


Asp Arg Cys Ser Val Cys Ser Cys Gln Asn Gly Phe Val Met Cys Arg 
            660                 665                 670         


Arg Met Val Cys Asp Cys Glu Asn Pro Thr Val Asp Leu Phe Cys Cys 
        675                 680                 685             


Pro Glu Cys Asp Pro Arg Leu Ser Ser Gln Cys Leu His Gln Asn Gly 
    690                 695                 700                 


Glu Thr Leu Tyr Asn Ser Gly Asp Thr Trp Val Gln Asn Cys Gln Gln 
705                 710                 715                 720 


Cys Arg Cys Leu Gln Gly Glu Val Asp Cys Trp Pro Leu Pro Cys Pro 
                725                 730                 735     


Asp Val Glu Cys Glu Phe Ser Ile Leu Pro Glu Asn Glu Cys Cys Pro 
            740                 745                 750         


Arg Cys Val Thr Asp Pro Cys Gln Ala Asp Thr Ile Arg Asn Asp Ile 
        755                 760                 765             


Thr Lys Thr Cys Leu Asp Glu Met Asn Val Val Arg Phe Thr Gly Ser 
    770                 775                 780                 


Ser Trp Ile Lys His Gly Thr Glu Cys Thr Leu Cys Gln Cys Lys Asn 
785                 790                 795                 800 


Gly His Ile Cys Cys Ser Val Asp Pro Gln Cys Leu Gln Glu Leu 
                805                 810                 815 


<210>  9302
<211>  768
<212>  PRT
<213>  Homo Sapiens

<400>  9302

Met Glu Thr Gly Leu Gly Ala Pro Leu Phe Lys Ala Trp Leu Leu Ile 
1               5                   10                  15      


Ser Val Trp Gly Leu Gly Val Asp Pro Ser Leu Gln Ile Asp Val Leu 
            20                  25                  30          


Thr Glu Leu Glu Leu Gly Glu Ser Thr Thr Gly Val Arg Gln Val Pro 
        35                  40                  45              


Gly Leu His Asn Gly Thr Lys Ala Phe Leu Phe Gln Asp Thr Pro Arg 
    50                  55                  60                  


Ser Ile Lys Ala Ser Thr Ala Thr Ala Glu Gln Phe Phe Gln Lys Leu 
65                  70                  75                  80  


Arg Asn Lys His Glu Phe Thr Ile Leu Val Thr Leu Lys Gln Thr His 
                85                  90                  95      


Leu Asn Ser Gly Val Ile Leu Ser Ile His His Leu Asp His Arg Tyr 
            100                 105                 110         


Leu Glu Leu Glu Ser Ser Gly His Arg Asn Glu Val Arg Leu His Tyr 
        115                 120                 125             


Arg Ser Gly Ser His Arg Pro His Thr Glu Val Phe Pro Tyr Ile Leu 
    130                 135                 140                 


Ala Asp Asp Lys Trp His Lys Leu Ser Leu Ala Ile Ser Ala Ser His 
145                 150                 155                 160 


Leu Ile Leu His Ile Asp Cys Asn Lys Ile Tyr Glu Arg Val Val Glu 
                165                 170                 175     


Lys Pro Ser Thr Asp Leu Pro Leu Gly Thr Thr Phe Trp Leu Gly Gln 
            180                 185                 190         


Arg Asn Asn Ala His Gly Tyr Phe Lys Gly Ile Met Gln Asp Val Gln 
        195                 200                 205             


Leu Leu Val Met Pro Gln Gly Phe Ile Ala Gln Cys Pro Asp Leu Asn 
    210                 215                 220                 


Arg Thr Cys Pro Thr Cys Asn Asp Phe His Gly Leu Val Gln Lys Ile 
225                 230                 235                 240 


Met Glu Leu Gln Asp Ile Leu Ala Lys Thr Ser Ala Lys Leu Ser Arg 
                245                 250                 255     


Ala Glu Gln Arg Met Asn Arg Leu Asp Gln Cys Tyr Cys Glu Arg Thr 
            260                 265                 270         


Cys Thr Met Lys Gly Thr Thr Tyr Arg Glu Phe Glu Ser Trp Ile Asp 
        275                 280                 285             


Gly Cys Lys Asn Cys Thr Cys Leu Asn Gly Thr Ile Gln Cys Glu Thr 
    290                 295                 300                 


Leu Ile Cys Pro Asn Pro Asp Cys Pro Leu Lys Ser Ala Leu Ala Tyr 
305                 310                 315                 320 


Val Asp Gly Lys Cys Cys Lys Glu Cys Lys Ser Ile Cys Gln Phe Gln 
                325                 330                 335     


Gly Arg Thr Tyr Phe Glu Gly Glu Arg Asn Thr Val Tyr Ser Ser Ser 
            340                 345                 350         


Gly Val Cys Val Leu Tyr Glu Cys Lys Asp Gln Thr Met Lys Leu Val 
        355                 360                 365             


Glu Ser Ser Gly Cys Pro Ala Leu Asp Cys Pro Glu Ser His Gln Ile 
    370                 375                 380                 


Thr Leu Ser His Ser Cys Cys Lys Val Cys Lys Gly Tyr Asp Phe Cys 
385                 390                 395                 400 


Ser Glu Arg His Asn Cys Met Glu Asn Ser Ile Cys Arg Asn Leu Asn 
                405                 410                 415     


Asp Arg Ala Val Cys Ser Cys Arg Asp Gly Phe Arg Ala Leu Arg Glu 
            420                 425                 430         


Asp Asn Ala Tyr Cys Glu Asp Ile Asp Glu Cys Ala Glu Gly Arg His 
        435                 440                 445             


Tyr Cys Arg Glu Asn Thr Met Cys Val Asn Thr Pro Gly Ser Phe Met 
    450                 455                 460                 


Cys Ile Cys Lys Thr Gly Tyr Ile Arg Ile Asp Asp Tyr Ser Cys Thr 
465                 470                 475                 480 


Glu His Asp Glu Cys Ile Thr Asn Gln His Asn Cys Asp Glu Asn Ala 
                485                 490                 495     


Leu Cys Phe Asn Thr Val Gly Gly His Asn Cys Val Cys Lys Pro Gly 
            500                 505                 510         


Tyr Thr Gly Asn Gly Thr Thr Cys Lys Ala Phe Cys Lys Asp Gly Cys 
        515                 520                 525             


Arg Asn Gly Gly Ala Cys Ile Ala Ala Asn Val Cys Ala Cys Pro Gln 
    530                 535                 540                 


Gly Phe Thr Gly Pro Ser Cys Glu Thr Asp Ile Asp Glu Cys Gly Thr 
545                 550                 555                 560 


Gly Arg His Ser Cys Ala Asn Asp Thr Ile Cys Phe Asn Leu Asp Gly 
                565                 570                 575     


Gly Tyr Asp Cys Arg Cys Pro His Gly Lys Asn Cys Thr Gly Asp Cys 
            580                 585                 590         


Ile His Asp Gly Lys Val Lys His Asn Gly Gln Ile Trp Val Leu Glu 
        595                 600                 605             


Asn Asp Arg Cys Ser Val Cys Ser Cys Gln Asn Gly Phe Val Met Cys 
    610                 615                 620                 


Arg Arg Met Val Cys Asp Cys Glu Asn Pro Thr Val Asp Leu Phe Cys 
625                 630                 635                 640 


Cys Pro Glu Cys Asp Pro Arg Leu Ser Ser Gln Cys Leu His Gln Asn 
                645                 650                 655     


Gly Glu Thr Leu Tyr Asn Ser Gly Asp Thr Trp Val Gln Asn Cys Gln 
            660                 665                 670         


Gln Cys Arg Cys Leu Gln Gly Glu Val Asp Cys Trp Pro Leu Pro Cys 
        675                 680                 685             


Pro Asp Val Glu Cys Glu Phe Ser Ile Leu Pro Glu Asn Glu Cys Cys 
    690                 695                 700                 


Pro Arg Cys Val Thr Asp Pro Cys Gln Ala Asp Thr Ile Arg Asn Asp 
705                 710                 715                 720 


Ile Thr Lys Thr Cys Leu Asp Glu Met Asn Val Val Arg Phe Thr Gly 
                725                 730                 735     


Ser Ser Trp Ile Lys His Gly Thr Glu Cys Thr Leu Cys Gln Cys Lys 
            740                 745                 750         


Asn Gly His Ile Cys Cys Ser Val Asp Pro Gln Cys Leu Gln Glu Leu 
        755                 760                 765             


<210>  9303
<211>  815
<212>  PRT
<213>  Homo Sapiens

<400>  9303

Met Glu Thr Gly Leu Gly Ala Pro Leu Phe Lys Ala Trp Leu Leu Ile 
1               5                   10                  15      


Ser Val Trp Gly Leu Gly Val Asp Pro Ser Leu Gln Ile Asp Val Leu 
            20                  25                  30          


Thr Glu Leu Glu Leu Gly Glu Ser Thr Thr Gly Val Arg Gln Val Pro 
        35                  40                  45              


Gly Leu His Asn Gly Thr Lys Ala Phe Leu Phe Gln Asp Thr Pro Arg 
    50                  55                  60                  


Ser Ile Lys Ala Ser Thr Ala Thr Ala Glu Gln Phe Phe Gln Lys Leu 
65                  70                  75                  80  


Arg Asn Lys His Glu Phe Thr Ile Leu Val Thr Leu Lys Gln Thr His 
                85                  90                  95      


Leu Asn Ser Gly Val Ile Leu Ser Ile His His Leu Asp His Arg Tyr 
            100                 105                 110         


Leu Glu Leu Glu Ser Ser Gly His Arg Asn Glu Val Arg Leu His Tyr 
        115                 120                 125             


Arg Ser Gly Ser His Arg Pro His Thr Glu Val Phe Pro Tyr Ile Leu 
    130                 135                 140                 


Ala Asp Asp Lys Trp His Lys Leu Ser Leu Ala Ile Ser Ala Ser His 
145                 150                 155                 160 


Leu Ile Leu His Ile Asp Cys Asn Lys Ile Tyr Glu Arg Val Val Glu 
                165                 170                 175     


Lys Pro Ser Thr Asp Leu Pro Leu Gly Thr Thr Phe Trp Leu Gly Gln 
            180                 185                 190         


Arg Asn Asn Ala His Gly Tyr Phe Lys Gly Ile Met Gln Asp Val Gln 
        195                 200                 205             


Leu Leu Val Met Pro Gln Gly Phe Ile Ala Gln Cys Pro Asp Leu Asn 
    210                 215                 220                 


Arg Thr Cys Pro Thr Cys Asn Asp Phe His Gly Leu Val Gln Lys Ile 
225                 230                 235                 240 


Met Glu Leu Gln Asp Ile Leu Ala Lys Thr Ser Ala Lys Leu Ser Arg 
                245                 250                 255     


Ala Glu Gln Arg Met Asn Arg Leu Asp Gln Cys Tyr Cys Glu Arg Thr 
            260                 265                 270         


Cys Thr Met Lys Gly Thr Thr Tyr Arg Glu Phe Glu Ser Trp Ile Asp 
        275                 280                 285             


Gly Cys Lys Asn Cys Thr Cys Leu Asn Gly Thr Ile Gln Cys Glu Thr 
    290                 295                 300                 


Leu Ile Cys Pro Asn Pro Asp Cys Pro Leu Lys Ser Ala Leu Ala Tyr 
305                 310                 315                 320 


Val Asp Gly Lys Cys Cys Lys Glu Cys Lys Ser Ile Cys Gln Phe Gln 
                325                 330                 335     


Gly Arg Thr Tyr Phe Glu Gly Glu Arg Asn Thr Val Tyr Ser Ser Ser 
            340                 345                 350         


Gly Val Cys Val Leu Tyr Glu Cys Lys Asp Gln Thr Met Lys Leu Val 
        355                 360                 365             


Glu Ser Ser Gly Cys Pro Ala Leu Asp Cys Pro Glu Ser His Gln Ile 
    370                 375                 380                 


Thr Leu Ser His Ser Cys Cys Lys Val Cys Lys Gly Tyr Asp Phe Cys 
385                 390                 395                 400 


Ser Glu Arg His Asn Cys Met Glu Asn Ser Ile Cys Arg Asn Leu Asn 
                405                 410                 415     


Asp Arg Ala Val Cys Ser Cys Arg Asp Gly Phe Arg Ala Leu Arg Glu 
            420                 425                 430         


Asp Asn Ala Tyr Cys Glu Asp Ile Asp Glu Cys Ala Glu Gly Arg His 
        435                 440                 445             


Tyr Cys Arg Glu Asn Thr Met Cys Val Asn Thr Pro Gly Ser Phe Met 
    450                 455                 460                 


Cys Ile Cys Lys Thr Gly Tyr Ile Arg Ile Asp Asp Tyr Ser Cys Thr 
465                 470                 475                 480 


Glu His Asp Glu Cys Ile Thr Asn Gln His Asn Cys Asp Glu Asn Ala 
                485                 490                 495     


Leu Cys Phe Asn Thr Val Gly Gly His Asn Cys Val Cys Lys Pro Gly 
            500                 505                 510         


Tyr Thr Gly Asn Gly Thr Thr Cys Lys Ala Phe Cys Lys Asp Gly Cys 
        515                 520                 525             


Arg Asn Gly Gly Ala Cys Ile Ala Ala Asn Val Cys Ala Cys Pro Gln 
    530                 535                 540                 


Gly Phe Thr Gly Pro Ser Cys Glu Thr Asp Ile Asp Glu Cys Ser Asp 
545                 550                 555                 560 


Gly Phe Val Gln Cys Asp Ser Arg Ala Asn Cys Ile Asn Leu Pro Gly 
                565                 570                 575     


Trp Tyr His Cys Glu Cys Arg Asp Gly Tyr His Asp Asn Gly Met Phe 
            580                 585                 590         


Ser Pro Ser Gly Glu Ser Cys Glu Asp Ile Asp Glu Cys Gly Thr Gly 
        595                 600                 605             


Arg His Ser Cys Ala Asn Asp Thr Ile Cys Phe Asn Leu Asp Gly Gly 
    610                 615                 620                 


Tyr Asp Cys Arg Cys Pro His Gly Lys Asn Cys Thr Gly Asp Cys Ile 
625                 630                 635                 640 


His Asp Gly Lys Val Lys His Asn Gly Gln Ile Trp Val Leu Glu Asn 
                645                 650                 655     


Asp Arg Cys Ser Val Cys Ser Cys Gln Asn Gly Phe Val Met Cys Arg 
            660                 665                 670         


Arg Met Val Cys Asp Cys Glu Asn Pro Thr Val Asp Leu Phe Cys Cys 
        675                 680                 685             


Pro Glu Cys Asp Pro Arg Leu Ser Ser Gln Cys Leu His Gln Asn Gly 
    690                 695                 700                 


Glu Thr Leu Tyr Asn Ser Gly Asp Thr Trp Val Gln Asn Cys Gln Gln 
705                 710                 715                 720 


Cys Arg Cys Leu Gln Gly Glu Val Asp Cys Trp Pro Leu Pro Cys Pro 
                725                 730                 735     


Asp Val Glu Cys Glu Phe Ser Ile Leu Pro Glu Asn Glu Cys Cys Pro 
            740                 745                 750         


Arg Cys Val Thr Asp Pro Cys Gln Ala Asp Thr Ile Arg Asn Asp Ile 
        755                 760                 765             


Thr Lys Thr Cys Leu Asp Glu Met Asn Val Val Arg Phe Thr Gly Ser 
    770                 775                 780                 


Ser Trp Ile Lys His Gly Thr Glu Cys Thr Leu Cys Gln Cys Lys Asn 
785                 790                 795                 800 


Gly His Ile Cys Cys Ser Val Asp Pro Gln Cys Leu Gln Glu Leu 
                805                 810                 815 


<210>  9304
<211>  866
<212>  PRT
<213>  Homo Sapiens

<400>  9304

Met Gly Phe Pro Pro Leu Leu Lys Gly Gln Ala Ser Ala Thr Arg Ser 
1               5                   10                  15      


Ser Leu Ala Ser Cys Ser Trp Val Val Phe Phe Leu Ser Cys Leu Ser 
            20                  25                  30          


Arg His Ala Pro Glu Ile Glu Gly Gly Arg Arg Trp Thr Glu Leu Ile 
        35                  40                  45              


Arg Thr Met Glu Ser Arg Val Leu Leu Arg Thr Phe Cys Leu Ile Phe 
    50                  55                  60                  


Gly Leu Gly Ala Val Trp Gly Leu Gly Val Asp Pro Ser Leu Gln Ile 
65                  70                  75                  80  


Asp Val Leu Thr Glu Leu Glu Leu Gly Glu Ser Thr Thr Gly Val Arg 
                85                  90                  95      


Gln Val Pro Gly Leu His Asn Gly Thr Lys Ala Phe Leu Phe Gln Asp 
            100                 105                 110         


Thr Pro Arg Ser Ile Lys Ala Ser Thr Ala Thr Ala Glu Gln Phe Phe 
        115                 120                 125             


Gln Lys Leu Arg Asn Lys His Glu Phe Thr Ile Leu Val Thr Leu Lys 
    130                 135                 140                 


Gln Thr His Leu Asn Ser Gly Val Ile Leu Ser Ile His His Leu Asp 
145                 150                 155                 160 


His Arg Tyr Leu Glu Leu Glu Ser Ser Gly His Arg Asn Glu Val Arg 
                165                 170                 175     


Leu His Tyr Arg Ser Gly Ser His Arg Pro His Thr Glu Val Phe Pro 
            180                 185                 190         


Tyr Ile Leu Ala Asp Asp Lys Trp His Lys Leu Ser Leu Ala Ile Ser 
        195                 200                 205             


Ala Ser His Leu Ile Leu His Ile Asp Cys Asn Lys Ile Tyr Glu Arg 
    210                 215                 220                 


Val Val Glu Lys Pro Ser Thr Asp Leu Pro Leu Gly Thr Thr Phe Trp 
225                 230                 235                 240 


Leu Gly Gln Arg Asn Asn Ala His Gly Tyr Phe Lys Gly Ile Met Gln 
                245                 250                 255     


Asp Val Gln Leu Leu Val Met Pro Gln Gly Phe Ile Ala Gln Cys Pro 
            260                 265                 270         


Asp Leu Asn Arg Thr Cys Pro Thr Cys Asn Asp Phe His Gly Leu Val 
        275                 280                 285             


Gln Lys Ile Met Glu Leu Gln Asp Ile Leu Ala Lys Thr Ser Ala Lys 
    290                 295                 300                 


Leu Ser Arg Ala Glu Gln Arg Met Asn Arg Leu Asp Gln Cys Tyr Cys 
305                 310                 315                 320 


Glu Arg Thr Cys Thr Met Lys Gly Thr Thr Tyr Arg Glu Phe Glu Ser 
                325                 330                 335     


Trp Ile Asp Gly Cys Lys Asn Cys Thr Cys Leu Asn Gly Thr Ile Gln 
            340                 345                 350         


Cys Glu Thr Leu Ile Cys Pro Asn Pro Asp Cys Pro Leu Lys Ser Ala 
        355                 360                 365             


Leu Ala Tyr Val Asp Gly Lys Cys Cys Lys Glu Cys Lys Ser Ile Cys 
    370                 375                 380                 


Gln Phe Gln Gly Arg Thr Tyr Phe Glu Gly Glu Arg Asn Thr Val Tyr 
385                 390                 395                 400 


Ser Ser Ser Gly Val Cys Val Leu Tyr Glu Cys Lys Asp Gln Thr Met 
                405                 410                 415     


Lys Leu Val Glu Ser Ser Gly Cys Pro Ala Leu Asp Cys Pro Glu Ser 
            420                 425                 430         


His Gln Ile Thr Leu Ser His Ser Cys Cys Lys Val Cys Lys Gly Tyr 
        435                 440                 445             


Asp Phe Cys Ser Glu Arg His Asn Cys Met Glu Asn Ser Ile Cys Arg 
    450                 455                 460                 


Asn Leu Asn Asp Arg Ala Val Cys Ser Cys Arg Asp Gly Phe Arg Ala 
465                 470                 475                 480 


Leu Arg Glu Asp Asn Ala Tyr Cys Glu Asp Ile Asp Glu Cys Ala Glu 
                485                 490                 495     


Gly Arg His Tyr Cys Arg Glu Asn Thr Met Cys Val Asn Thr Pro Gly 
            500                 505                 510         


Ser Phe Met Cys Ile Cys Lys Thr Gly Tyr Ile Arg Ile Asp Asp Tyr 
        515                 520                 525             


Ser Cys Thr Glu His Asp Glu Cys Ile Thr Asn Gln His Asn Cys Asp 
    530                 535                 540                 


Glu Asn Ala Leu Cys Phe Asn Thr Val Gly Gly His Asn Cys Val Cys 
545                 550                 555                 560 


Lys Pro Gly Tyr Thr Gly Asn Gly Thr Thr Cys Lys Ala Phe Cys Lys 
                565                 570                 575     


Asp Gly Cys Arg Asn Gly Gly Ala Cys Ile Ala Ala Asn Val Cys Ala 
            580                 585                 590         


Cys Pro Gln Gly Phe Thr Gly Pro Ser Cys Glu Thr Asp Ile Asp Glu 
        595                 600                 605             


Cys Ser Asp Gly Phe Val Gln Cys Asp Ser Arg Ala Asn Cys Ile Asn 
    610                 615                 620                 


Leu Pro Gly Trp Tyr His Cys Glu Cys Arg Asp Gly Tyr His Asp Asn 
625                 630                 635                 640 


Gly Met Phe Ser Pro Ser Gly Glu Ser Cys Glu Asp Ile Asp Glu Cys 
                645                 650                 655     


Gly Thr Gly Arg His Ser Cys Ala Asn Asp Thr Ile Cys Phe Asn Leu 
            660                 665                 670         


Asp Gly Gly Tyr Asp Cys Arg Cys Pro His Gly Lys Asn Cys Thr Gly 
        675                 680                 685             


Asp Cys Ile His Asp Gly Lys Val Lys His Asn Gly Gln Ile Trp Val 
    690                 695                 700                 


Leu Glu Asn Asp Arg Cys Ser Val Cys Ser Cys Gln Asn Gly Phe Val 
705                 710                 715                 720 


Met Cys Arg Arg Met Val Cys Asp Cys Glu Asn Pro Thr Val Asp Leu 
                725                 730                 735     


Phe Cys Cys Pro Glu Cys Asp Pro Arg Leu Ser Ser Gln Cys Leu His 
            740                 745                 750         


Gln Asn Gly Glu Thr Leu Tyr Asn Ser Gly Asp Thr Trp Val Gln Asn 
        755                 760                 765             


Cys Gln Gln Cys Arg Cys Leu Gln Gly Glu Val Asp Cys Trp Pro Leu 
    770                 775                 780                 


Pro Cys Pro Asp Val Glu Cys Glu Phe Ser Ile Leu Pro Glu Asn Glu 
785                 790                 795                 800 


Cys Cys Pro Arg Cys Val Thr Asp Pro Cys Gln Ala Asp Thr Ile Arg 
                805                 810                 815     


Asn Asp Ile Thr Lys Thr Cys Leu Asp Glu Met Asn Val Val Arg Phe 
            820                 825                 830         


Thr Gly Ser Ser Trp Ile Lys His Gly Thr Glu Cys Thr Leu Cys Gln 
        835                 840                 845             


Cys Lys Asn Gly His Ile Cys Cys Ser Val Asp Pro Gln Cys Leu Gln 
    850                 855                 860                 


Glu Leu 
865     


<210>  9305
<211>  839
<212>  PRT
<213>  Homo Sapiens

<400>  9305

Met Ser Ile Arg Arg Leu Leu Ile Leu Ile Leu Lys Ile Gly Arg Arg 
1               5                   10                  15      


Trp Thr Glu Leu Ile Arg Thr Met Glu Ser Arg Val Leu Leu Arg Thr 
            20                  25                  30          


Phe Cys Leu Ile Phe Gly Leu Gly Ala Val Trp Gly Leu Gly Val Asp 
        35                  40                  45              


Pro Ser Leu Gln Ile Asp Val Leu Thr Glu Leu Glu Leu Gly Glu Ser 
    50                  55                  60                  


Thr Thr Gly Val Arg Gln Val Pro Gly Leu His Asn Gly Thr Lys Ala 
65                  70                  75                  80  


Phe Leu Phe Gln Asp Thr Pro Arg Ser Ile Lys Ala Ser Thr Ala Thr 
                85                  90                  95      


Ala Glu Gln Phe Phe Gln Lys Leu Arg Asn Lys His Glu Phe Thr Ile 
            100                 105                 110         


Leu Val Thr Leu Lys Gln Thr His Leu Asn Ser Gly Val Ile Leu Ser 
        115                 120                 125             


Ile His His Leu Asp His Arg Tyr Leu Glu Leu Glu Ser Ser Gly His 
    130                 135                 140                 


Arg Asn Glu Val Arg Leu His Tyr Arg Ser Gly Ser His Arg Pro His 
145                 150                 155                 160 


Thr Glu Val Phe Pro Tyr Ile Leu Ala Asp Asp Lys Trp His Lys Leu 
                165                 170                 175     


Ser Leu Ala Ile Ser Ala Ser His Leu Ile Leu His Ile Asp Cys Asn 
            180                 185                 190         


Lys Ile Tyr Glu Arg Val Val Glu Lys Pro Ser Thr Asp Leu Pro Leu 
        195                 200                 205             


Gly Thr Thr Phe Trp Leu Gly Gln Arg Asn Asn Ala His Gly Tyr Phe 
    210                 215                 220                 


Lys Gly Ile Met Gln Asp Val Gln Leu Leu Val Met Pro Gln Gly Phe 
225                 230                 235                 240 


Ile Ala Gln Cys Pro Asp Leu Asn Arg Thr Cys Pro Thr Cys Asn Asp 
                245                 250                 255     


Phe His Gly Leu Val Gln Lys Ile Met Glu Leu Gln Asp Ile Leu Ala 
            260                 265                 270         


Lys Thr Ser Ala Lys Leu Ser Arg Ala Glu Gln Arg Met Asn Arg Leu 
        275                 280                 285             


Asp Gln Cys Tyr Cys Glu Arg Thr Cys Thr Met Lys Gly Thr Thr Tyr 
    290                 295                 300                 


Arg Glu Phe Glu Ser Trp Ile Asp Gly Cys Lys Asn Cys Thr Cys Leu 
305                 310                 315                 320 


Asn Gly Thr Ile Gln Cys Glu Thr Leu Ile Cys Pro Asn Pro Asp Cys 
                325                 330                 335     


Pro Leu Lys Ser Ala Leu Ala Tyr Val Asp Gly Lys Cys Cys Lys Glu 
            340                 345                 350         


Cys Lys Ser Ile Cys Gln Phe Gln Gly Arg Thr Tyr Phe Glu Gly Glu 
        355                 360                 365             


Arg Asn Thr Val Tyr Ser Ser Ser Gly Val Cys Val Leu Tyr Glu Cys 
    370                 375                 380                 


Lys Asp Gln Thr Met Lys Leu Val Glu Ser Ser Gly Cys Pro Ala Leu 
385                 390                 395                 400 


Asp Cys Pro Glu Ser His Gln Ile Thr Leu Ser His Ser Cys Cys Lys 
                405                 410                 415     


Val Cys Lys Gly Tyr Asp Phe Cys Ser Glu Arg His Asn Cys Met Glu 
            420                 425                 430         


Asn Ser Ile Cys Arg Asn Leu Asn Asp Arg Ala Val Cys Ser Cys Arg 
        435                 440                 445             


Asp Gly Phe Arg Ala Leu Arg Glu Asp Asn Ala Tyr Cys Glu Asp Ile 
    450                 455                 460                 


Asp Glu Cys Ala Glu Gly Arg His Tyr Cys Arg Glu Asn Thr Met Cys 
465                 470                 475                 480 


Val Asn Thr Pro Gly Ser Phe Met Cys Ile Cys Lys Thr Gly Tyr Ile 
                485                 490                 495     


Arg Ile Asp Asp Tyr Ser Cys Thr Glu His Asp Glu Cys Ile Thr Asn 
            500                 505                 510         


Gln His Asn Cys Asp Glu Asn Ala Leu Cys Phe Asn Thr Val Gly Gly 
        515                 520                 525             


His Asn Cys Val Cys Lys Pro Gly Tyr Thr Gly Asn Gly Thr Thr Cys 
    530                 535                 540                 


Lys Ala Phe Cys Lys Asp Gly Cys Arg Asn Gly Gly Ala Cys Ile Ala 
545                 550                 555                 560 


Ala Asn Val Cys Ala Cys Pro Gln Gly Phe Thr Gly Pro Ser Cys Glu 
                565                 570                 575     


Thr Asp Ile Asp Glu Cys Ser Asp Gly Phe Val Gln Cys Asp Ser Arg 
            580                 585                 590         


Ala Asn Cys Ile Asn Leu Pro Gly Trp Tyr His Cys Glu Cys Arg Asp 
        595                 600                 605             


Gly Tyr His Asp Asn Gly Met Phe Ser Pro Ser Gly Glu Ser Cys Glu 
    610                 615                 620                 


Asp Ile Asp Glu Cys Gly Thr Gly Arg His Ser Cys Ala Asn Asp Thr 
625                 630                 635                 640 


Ile Cys Phe Asn Leu Asp Gly Gly Tyr Asp Cys Arg Cys Pro His Gly 
                645                 650                 655     


Lys Asn Cys Thr Gly Asp Cys Ile His Asp Gly Lys Val Lys His Asn 
            660                 665                 670         


Gly Gln Ile Trp Val Leu Glu Asn Asp Arg Cys Ser Val Cys Ser Cys 
        675                 680                 685             


Gln Asn Gly Phe Val Met Cys Arg Arg Met Val Cys Asp Cys Glu Asn 
    690                 695                 700                 


Pro Thr Val Asp Leu Phe Cys Cys Pro Glu Cys Asp Pro Arg Leu Ser 
705                 710                 715                 720 


Ser Gln Cys Leu His Gln Asn Gly Glu Thr Leu Tyr Asn Ser Gly Asp 
                725                 730                 735     


Thr Trp Val Gln Asn Cys Gln Gln Cys Arg Cys Leu Gln Gly Glu Val 
            740                 745                 750         


Asp Cys Trp Pro Leu Pro Cys Pro Asp Val Glu Cys Glu Phe Ser Ile 
        755                 760                 765             


Leu Pro Glu Asn Glu Cys Cys Pro Arg Cys Val Thr Asp Pro Cys Gln 
    770                 775                 780                 


Ala Asp Thr Ile Arg Asn Asp Ile Thr Lys Thr Cys Leu Asp Glu Met 
785                 790                 795                 800 


Asn Val Val Arg Phe Thr Gly Ser Ser Trp Ile Lys His Gly Thr Glu 
                805                 810                 815     


Cys Thr Leu Cys Gln Cys Lys Asn Gly His Ile Cys Cys Ser Val Asp 
            820                 825                 830         


Pro Gln Cys Leu Gln Glu Leu 
        835                 


<210>  9306
<211>  246
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9306

Xaa Ala Lys Leu Ser Arg Ala Glu Gln Arg Met Asn Arg Leu Asp Gln 
1               5                   10                  15      


Cys Tyr Cys Glu Arg Thr Cys Thr Met Lys Gly Thr Thr Tyr Arg Glu 
            20                  25                  30          


Phe Glu Ser Trp Ile Asp Gly Cys Lys Asn Cys Thr Cys Leu Asn Gly 
        35                  40                  45              


Thr Ile Gln Cys Glu Thr Leu Ile Cys Pro Asn Pro Asp Cys Pro Leu 
    50                  55                  60                  


Lys Ser Ala Leu Ala Tyr Val Asp Gly Lys Cys Ser Ile Cys Gln Phe 
65                  70                  75                  80  


Gln Gly Arg Thr Tyr Phe Glu Gly Glu Arg Asn Thr Val Tyr Ser Ser 
                85                  90                  95      


Ser Gly Val Cys Val Leu Tyr Glu Cys Lys Asp Gln Thr Met Lys Leu 
            100                 105                 110         


Val Glu Ser Ser Gly Cys Pro Ala Leu Asp Cys Pro Glu Ser His Gln 
        115                 120                 125             


Ile Thr Leu Ser His Ser Cys Cys Lys Val Cys Lys Gly Tyr Asp Phe 
    130                 135                 140                 


Cys Ser Glu Arg His Asn Cys Met Glu Asn Ser Ile Cys Arg Asn Leu 
145                 150                 155                 160 


Asn Asp Arg Ala Val Cys Ser Cys Arg Asp Gly Phe Arg Ala Leu Arg 
                165                 170                 175     


Glu Asp Asn Ala Tyr Cys Glu Asp Ile Asp Glu Cys Ala Glu Gly Arg 
            180                 185                 190         


His Tyr Cys Arg Glu Asn Thr Met Cys Val Asn Thr Pro Gly Ser Phe 
        195                 200                 205             


Met Cys Ile Cys Lys Thr Gly Tyr Ile Arg Ile Asp Asp Tyr Ser Cys 
    210                 215                 220                 


Thr Glu His Asp Glu Cys Ile Thr Asn Gln His Asn Cys Asp Glu Asn 
225                 230                 235                 240 


Ala Leu Cys Phe Asn Thr 
                245     


<210>  9307
<211>  86
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9307

Xaa Asp Asn Gly Met Phe Ser Pro Ser Gly Glu Ser Cys Glu Asp Ile 
1               5                   10                  15      


Asp Glu Cys Gly Thr Gly Arg His Ser Cys Ala Asn Asp Thr Ile Cys 
            20                  25                  30          


Phe Asn Leu Asp Gly Gly Tyr Asp Cys Arg Cys Pro His Gly Lys Asn 
        35                  40                  45              


Cys Thr Gly Asp Cys Ile His Asp Gly Lys Val Lys His Asn Gly Gln 
    50                  55                  60                  


Ile Trp Val Leu Glu Asn Asp Arg Cys Ser Val Cys Ser Cys Gln Val 
65                  70                  75                  80  


Gly Ile Asn Glu Lys Leu 
                85      


<210>  9308
<211>  172
<212>  PRT
<213>  Homo Sapiens

<400>  9308

Met Val Gly Pro Ala Pro Arg Arg Arg Leu Arg Pro Leu Ala Ala Leu 
1               5                   10                  15      


Ala Leu Val Leu Ala Leu Ala Pro Gly Leu Pro Thr Ala Arg Ala Gly 
            20                  25                  30          


Gln Thr Pro Arg Pro Ala Glu Arg Gly Pro Pro Val Arg Leu Phe Thr 
        35                  40                  45              


Glu Glu Glu Leu Ala Arg Tyr Gly Gly Glu Glu Glu Asp Gln Pro Ile 
    50                  55                  60                  


Tyr Leu Ala Val Lys Gly Val Val Phe Asp Val Thr Ser Gly Lys Glu 
65                  70                  75                  80  


Phe Tyr Gly Arg Gly Ala Pro Tyr Asn Ala Leu Thr Gly Lys Asp Ser 
                85                  90                  95      


Thr Arg Gly Val Ala Lys Met Ser Leu Asp Pro Ala Asp Leu Thr His 
            100                 105                 110         


Asp Thr Thr Gly Leu Thr Ala Lys Glu Leu Glu Ala Leu Asp Glu Val 
        115                 120                 125             


Phe Thr Lys Val Tyr Lys Ala Lys Tyr Pro Ile Val Gly Tyr Thr Ala 
    130                 135                 140                 


Arg Arg Ile Leu Asn Glu Asp Gly Ser Pro Asn Leu Asp Phe Lys Pro 
145                 150                 155                 160 


Glu Asp Gln Pro His Phe Asp Ile Lys Asp Glu Phe 
                165                 170         


<210>  9309
<211>  533
<212>  PRT
<213>  Homo Sapiens

<400>  9309

Met Ile His Gly Arg Ser Val Leu His Ile Val Ala Ser Leu Ile Ile 
1               5                   10                  15      


Leu His Leu Ser Gly Ala Thr Lys Lys Gly Thr Glu Lys Gln Thr Thr 
            20                  25                  30          


Ser Glu Thr Gln Lys Ser Val Gln Cys Gly Thr Trp Thr Lys His Ala 
        35                  40                  45              


Glu Gly Gly Ile Phe Thr Ser Pro Asn Tyr Pro Ser Lys Tyr Pro Pro 
    50                  55                  60                  


Asp Arg Glu Cys Ile Tyr Ile Ile Glu Ala Ala Pro Arg Gln Cys Ile 
65                  70                  75                  80  


Glu Leu Tyr Phe Asp Glu Lys Tyr Ser Ile Glu Pro Ser Trp Glu Cys 
                85                  90                  95      


Lys Phe Asp His Ile Glu Val Arg Asp Gly Pro Phe Gly Phe Ser Pro 
            100                 105                 110         


Ile Ile Gly Arg Phe Cys Gly Gln Gln Asn Pro Pro Val Ile Lys Ser 
        115                 120                 125             


Ser Gly Arg Phe Leu Trp Ile Lys Phe Phe Ala Asp Gly Glu Leu Glu 
    130                 135                 140                 


Ser Met Gly Phe Ser Ala Arg Tyr Asn Phe Thr Pro Asp Pro Asp Phe 
145                 150                 155                 160 


Lys Asp Leu Gly Ala Leu Lys Pro Leu Pro Ala Cys Glu Phe Glu Met 
                165                 170                 175     


Gly Gly Ser Glu Gly Ile Val Glu Ser Ile Gln Ile Met Lys Glu Gly 
            180                 185                 190         


Lys Ala Thr Ala Ser Glu Ala Val Asp Cys Lys Trp Tyr Ile Arg Ala 
        195                 200                 205             


Pro Pro Arg Ser Lys Ile Tyr Leu Arg Phe Leu Asp Tyr Glu Met Gln 
    210                 215                 220                 


Asn Ser Asn Glu Cys Lys Arg Asn Phe Val Ala Val Tyr Asp Gly Ser 
225                 230                 235                 240 


Ser Ser Val Glu Asp Leu Lys Ala Lys Phe Cys Ser Thr Val Ala Asn 
                245                 250                 255     


Asp Val Met Leu Arg Thr Gly Leu Gly Val Ile Arg Met Trp Ala Asp 
            260                 265                 270         


Glu Gly Ser Arg Asn Ser Arg Phe Gln Met Leu Phe Thr Ser Phe Gln 
        275                 280                 285             


Glu Pro Pro Cys Glu Gly Asn Thr Phe Phe Cys His Ser Asn Met Cys 
    290                 295                 300                 


Ile Asn Asn Thr Leu Val Cys Asn Gly Leu Gln Asn Cys Val Tyr Pro 
305                 310                 315                 320 


Trp Asp Glu Asn His Cys Lys Glu Lys Arg Lys Thr Ser Leu Leu Asp 
                325                 330                 335     


Gln Leu Thr Asn Thr Ser Gly Thr Val Ile Gly Val Thr Ser Cys Ile 
            340                 345                 350         


Val Ile Ile Leu Ile Ile Ile Ser Val Ile Val Gln Ile Lys Gln Pro 
        355                 360                 365             


Arg Lys Lys Tyr Val Gln Arg Lys Ser Asp Phe Asp Gln Thr Val Phe 
    370                 375                 380                 


Gln Glu Val Phe Glu Pro Pro His Tyr Glu Leu Cys Thr Leu Arg Gly 
385                 390                 395                 400 


Thr Gly Ala Thr Ala Asp Phe Ala Asp Val Ala Asp Asp Phe Glu Asn 
                405                 410                 415     


Tyr His Lys Leu Arg Arg Ser Ser Ser Lys Cys Ile His Asp His His 
            420                 425                 430         


Cys Gly Ser Gln Leu Ser Ser Thr Lys Gly Ser Arg Ser Asn Leu Ser 
        435                 440                 445             


Thr Arg Asp Ala Ser Ile Leu Thr Glu Met Pro Thr Gln Pro Gly Lys 
    450                 455                 460                 


Pro Leu Ile Pro Pro Met Asn Arg Arg Asn Ile Leu Val Met Lys His 
465                 470                 475                 480 


Ser Tyr Ser Gln Asp Ala Ala Asp Ala Cys Asp Ile Asp Glu Ile Glu 
                485                 490                 495     


Glu Val Pro Thr Thr Ser His Arg Leu Ser Arg His Asp Lys Ala Val 
            500                 505                 510         


Gln Arg Phe Cys Leu Ile Gly Ser Leu Ser Lys His Glu Ser Glu Tyr 
        515                 520                 525             


Asn Thr Thr Arg Val 
    530             


<210>  9310
<211>  533
<212>  PRT
<213>  Homo Sapiens

<400>  9310

Met Ile His Gly Arg Ser Val Leu His Ile Val Ala Ser Leu Ile Ile 
1               5                   10                  15      


Leu His Leu Ser Gly Ala Thr Lys Lys Gly Thr Glu Lys Gln Thr Thr 
            20                  25                  30          


Ser Glu Thr Gln Lys Ser Val Gln Cys Gly Thr Trp Thr Lys His Ala 
        35                  40                  45              


Glu Gly Gly Ile Phe Thr Ser Pro Asn Tyr Pro Ser Lys Tyr Pro Pro 
    50                  55                  60                  


Asp Arg Glu Cys Ile Tyr Ile Ile Glu Ala Ala Pro Arg Gln Cys Ile 
65                  70                  75                  80  


Glu Leu Tyr Phe Asp Glu Lys Tyr Ser Ile Glu Pro Ser Trp Glu Cys 
                85                  90                  95      


Lys Phe Asp His Ile Glu Val Arg Asp Gly Pro Phe Gly Phe Ser Pro 
            100                 105                 110         


Ile Ile Gly Arg Phe Cys Gly Gln Gln Asn Pro Pro Val Ile Lys Ser 
        115                 120                 125             


Ser Gly Arg Phe Leu Trp Ile Lys Phe Phe Ala Asp Gly Glu Leu Glu 
    130                 135                 140                 


Ser Met Gly Phe Ser Ala Arg Tyr Asn Phe Thr Pro Asp Pro Asp Phe 
145                 150                 155                 160 


Lys Asp Leu Gly Ala Leu Lys Pro Leu Pro Ala Cys Glu Phe Glu Met 
                165                 170                 175     


Gly Gly Ser Glu Gly Ile Val Glu Ser Ile Gln Ile Met Lys Glu Gly 
            180                 185                 190         


Lys Ala Thr Ala Ser Glu Ala Val Asp Cys Lys Trp Tyr Ile Arg Ala 
        195                 200                 205             


Pro Pro Arg Ser Lys Ile Tyr Leu Arg Phe Leu Asp Tyr Glu Met Gln 
    210                 215                 220                 


Asn Ser Asn Glu Cys Lys Arg Asn Phe Val Ala Val Tyr Asp Gly Ser 
225                 230                 235                 240 


Ser Ser Val Glu Asp Leu Lys Ala Lys Phe Cys Ser Thr Val Ala Asn 
                245                 250                 255     


Asp Val Met Leu Arg Thr Gly Leu Gly Val Ile Arg Met Trp Ala Asp 
            260                 265                 270         


Glu Gly Ser Arg Asn Ser Arg Phe Gln Met Leu Phe Thr Ser Phe Gln 
        275                 280                 285             


Glu Pro Pro Cys Glu Gly Asn Thr Phe Phe Cys His Ser Asn Met Cys 
    290                 295                 300                 


Ile Asn Asn Thr Leu Val Cys Asn Gly Leu Gln Asn Cys Val Tyr Pro 
305                 310                 315                 320 


Trp Asp Glu Asn His Cys Lys Glu Lys Arg Lys Thr Ser Leu Leu Asp 
                325                 330                 335     


Gln Leu Thr Asn Thr Ser Gly Thr Val Ile Gly Val Thr Ser Cys Ile 
            340                 345                 350         


Val Ile Ile Leu Ile Ile Ile Ser Val Ile Val Gln Ile Lys Gln Pro 
        355                 360                 365             


Arg Lys Lys Tyr Val Gln Arg Lys Ser Asp Phe Asp Gln Thr Val Phe 
    370                 375                 380                 


Gln Glu Val Phe Glu Pro Pro His Tyr Glu Leu Cys Thr Leu Arg Gly 
385                 390                 395                 400 


Thr Gly Ala Thr Ala Asp Phe Ala Asp Val Ala Asp Asp Phe Glu Asn 
                405                 410                 415     


Tyr His Lys Leu Arg Arg Ser Ser Ser Lys Cys Ile His Asp His His 
            420                 425                 430         


Cys Gly Ser Gln Leu Ser Ser Thr Lys Gly Ser Arg Ser Asn Leu Ser 
        435                 440                 445             


Thr Arg Asp Ala Ser Ile Leu Thr Glu Met Pro Thr Gln Pro Gly Lys 
    450                 455                 460                 


Pro Leu Ile Pro Pro Met Asn Arg Arg Asn Ile Leu Val Met Lys His 
465                 470                 475                 480 


Ser Tyr Ser Gln Asp Ala Ala Asp Ala Cys Asp Ile Asp Glu Ile Glu 
                485                 490                 495     


Glu Val Pro Thr Thr Ser His Arg Leu Ser Arg His Asp Lys Ala Val 
            500                 505                 510         


Gln Arg Phe Cys Leu Ile Gly Ser Leu Ser Lys His Glu Ser Glu Tyr 
        515                 520                 525             


Asn Thr Thr Arg Val 
    530             


<210>  9311
<211>  156
<212>  PRT
<213>  Homo Sapiens

<400>  9311

Met Leu Ala Glu Pro Phe Pro Lys Val Val Ala Ser Leu Ile Ile Leu 
1               5                   10                  15      


His Leu Ser Gly Ala Thr Lys Lys Gly Thr Glu Lys Gln Thr Thr Ser 
            20                  25                  30          


Glu Thr Gln Lys Ser Val Gln Cys Gly Thr Trp Thr Lys His Ala Glu 
        35                  40                  45              


Gly Gly Ile Phe Thr Ser Pro Asn Tyr Pro Ser Lys Tyr Pro Pro Asp 
    50                  55                  60                  


Arg Glu Cys Ile Tyr Ile Ile Glu Ala Ala Pro Arg Gln Cys Ile Glu 
65                  70                  75                  80  


Leu Tyr Phe Asp Glu Lys Tyr Ser Ile Glu Pro Ser Trp Glu Cys Lys 
                85                  90                  95      


Phe Asp His Ile Glu Val Arg Asp Gly Pro Phe Gly Phe Ser Pro Ile 
            100                 105                 110         


Ile Gly Arg Phe Cys Gly Gln Gln Asn Pro Pro Val Ile Lys Ser Ser 
        115                 120                 125             


Gly Arg Phe Leu Trp Ile Lys Phe Phe Ala Asp Gly Glu Leu Glu Ser 
    130                 135                 140                 


Met Gly Phe Ser Ala Arg Tyr Asn Phe Thr Pro Glu 
145                 150                 155     


<210>  9312
<211>  101
<212>  PRT
<213>  Homo Sapiens

<400>  9312

Met Ser Leu Tyr Gly Phe Val Ala Ser Leu Ile Ile Leu His Leu Ser 
1               5                   10                  15      


Gly Ala Thr Lys Lys Gly Thr Glu Lys Gln Thr Thr Ser Glu Thr Gln 
            20                  25                  30          


Lys Ser Val Gln Cys Gly Thr Trp Thr Lys His Ala Glu Gly Gly Ile 
        35                  40                  45              


Phe Thr Ser Pro Asn Tyr Pro Ser Lys Tyr Pro Pro Asp Arg Glu Cys 
    50                  55                  60                  


Ile Tyr Ile Ile Glu Ala Ala Pro Arg Gln Cys Ile Glu Leu Tyr Phe 
65                  70                  75                  80  


Asp Glu Lys Tyr Ser Ile Glu Pro Ser Trp Glu Cys Lys Phe Asp His 
                85                  90                  95      


Ile Glu Val Arg Asp 
            100     


<210>  9313
<211>  1165
<212>  PRT
<213>  Homo Sapiens

<400>  9313

Ile Glu Ile Pro Met Asp Leu Thr Gln Pro Pro Thr Ile Thr Lys Gln 
1               5                   10                  15      


Ser Ala Lys Asp His Ile Val Asp Pro Arg Asp Asn Ile Leu Ile Glu 
            20                  25                  30          


Cys Glu Ala Lys Gly Asn Pro Ala Pro Ser Phe His Trp Thr Arg Asn 
        35                  40                  45              


Ser Arg Phe Phe Asn Ile Ala Lys Asp Pro Arg Val Ser Met Arg Arg 
    50                  55                  60                  


Arg Ser Gly Thr Leu Val Ile Asp Phe Arg Ser Gly Gly Arg Pro Glu 
65                  70                  75                  80  


Glu Tyr Glu Gly Glu Tyr Gln Cys Phe Ala Arg Asn Lys Phe Gly Thr 
                85                  90                  95      


Ala Leu Ser Asn Arg Ile Arg Leu Gln Val Ser Lys Ser Pro Leu Trp 
            100                 105                 110         


Pro Lys Glu Asn Leu Asp Pro Val Val Val Gln Glu Gly Ala Pro Leu 
        115                 120                 125             


Thr Leu Gln Cys Asn Pro Pro Pro Gly Leu Pro Ser Pro Val Ile Phe 
    130                 135                 140                 


Trp Met Ser Ser Ser Met Glu Pro Ile Thr Gln Asp Lys Arg Val Ser 
145                 150                 155                 160 


Gln Gly His Asn Gly Asp Leu Tyr Phe Ser Asn Val Met Leu Gln Asp 
                165                 170                 175     


Met Gln Thr Asp Tyr Ser Cys Asn Ala Arg Phe His Phe Thr His Thr 
            180                 185                 190         


Ile Gln Gln Lys Asn Pro Phe Thr Leu Lys Val Leu Thr Asn His Pro 
        195                 200                 205             


Tyr Asn Asp Ser Ser Leu Arg Asn His Pro Asp Met Tyr Ser Ala Arg 
    210                 215                 220                 


Gly Val Ala Glu Arg Thr Pro Ser Phe Met Tyr Pro Gln Gly Thr Ala 
225                 230                 235                 240 


Ser Ser Gln Met Val Leu Arg Gly Met Asp Leu Leu Leu Glu Cys Ile 
                245                 250                 255     


Ala Ser Gly Val Pro Thr Pro Asp Ile Ala Trp Tyr Lys Lys Gly Gly 
            260                 265                 270         


Asp Leu Pro Ser Asp Lys Ala Lys Phe Glu Asn Phe Asn Lys Ala Leu 
        275                 280                 285             


Arg Ile Thr Asn Val Ser Glu Glu Asp Ser Gly Glu Tyr Phe Cys Leu 
    290                 295                 300                 


Ala Ser Asn Lys Met Gly Ser Ile Arg His Thr Ile Ser Val Arg Val 
305                 310                 315                 320 


Lys Ala Ala Pro Tyr Trp Leu Asp Glu Pro Lys Asn Leu Ile Leu Ala 
                325                 330                 335     


Pro Gly Glu Asp Gly Arg Leu Val Cys Arg Ala Asn Gly Asn Pro Lys 
            340                 345                 350         


Pro Thr Val Gln Trp Met Val Asn Gly Glu Pro Leu Gln Ser Ala Pro 
        355                 360                 365             


Pro Asn Pro Asn Arg Glu Val Ala Gly Asp Thr Ile Ile Phe Arg Asp 
    370                 375                 380                 


Thr Gln Ile Ser Ser Arg Ala Val Tyr Gln Cys Asn Thr Ser Asn Glu 
385                 390                 395                 400 


His Gly Tyr Leu Leu Ala Asn Ala Phe Val Ser Val Leu Asp Val Pro 
                405                 410                 415     


Pro Arg Met Leu Ser Pro Arg Asn Gln Leu Ile Arg Val Ile Leu Tyr 
            420                 425                 430         


Asn Arg Thr Arg Leu Asp Cys Pro Phe Phe Gly Ser Pro Ile Pro Thr 
        435                 440                 445             


Leu Arg Trp Phe Lys Asn Gly Gln Gly Ser Asn Leu Asp Gly Gly Asn 
    450                 455                 460                 


Tyr His Val Tyr Glu Asn Gly Ser Leu Glu Ile Lys Met Ile Arg Lys 
465                 470                 475                 480 


Glu Asp Gln Gly Ile Tyr Thr Cys Val Ala Thr Asn Ile Leu Gly Lys 
                485                 490                 495     


Ala Glu Asn Gln Val Arg Leu Glu Val Lys Asp Pro Thr Arg Ile Tyr 
            500                 505                 510         


Arg Met Pro Glu Asp Gln Val Ala Arg Arg Gly Thr Thr Val Gln Leu 
        515                 520                 525             


Glu Cys Arg Val Lys His Asp Pro Ser Leu Lys Leu Thr Val Ser Trp 
    530                 535                 540                 


Leu Lys Asp Asp Glu Pro Leu Tyr Ile Gly Asn Arg Met Lys Lys Glu 
545                 550                 555                 560 


Asp Asp Ser Leu Thr Ile Phe Gly Val Ala Glu Arg Asp Gln Gly Ser 
                565                 570                 575     


Tyr Thr Cys Val Ala Ser Thr Glu Leu Asp Gln Asp Leu Ala Lys Ala 
            580                 585                 590         


Tyr Leu Thr Val Leu Ala Asp Gln Ala Thr Pro Thr Asn Arg Leu Ala 
        595                 600                 605             


Ala Leu Pro Lys Gly Arg Pro Asp Arg Pro Arg Asp Leu Glu Leu Thr 
    610                 615                 620                 


Asp Leu Ala Glu Arg Ser Val Arg Leu Thr Trp Ile Pro Gly Asp Ala 
625                 630                 635                 640 


Asn Asn Ser Pro Ile Thr Asp Tyr Val Val Gln Phe Glu Glu Asp Gln 
                645                 650                 655     


Phe Gln Pro Gly Val Trp His Asp His Ser Lys Tyr Pro Gly Ser Val 
            660                 665                 670         


Asn Ser Ala Val Leu Arg Leu Ser Pro Tyr Val Asn Tyr Gln Phe Arg 
        675                 680                 685             


Val Ile Ala Ile Asn Glu Val Gly Ser Ser His Pro Ser Leu Pro Ser 
    690                 695                 700                 


Glu Arg Tyr Arg Thr Ser Gly Ala Pro Pro Glu Ser Asn Pro Gly Asp 
705                 710                 715                 720 


Val Lys Gly Glu Gly Thr Arg Lys Asn Asn Met Glu Ile Thr Trp Thr 
                725                 730                 735     


Pro Met Asn Ala Thr Ser Ala Phe Gly Pro Asn Leu Arg Tyr Ile Val 
            740                 745                 750         


Lys Trp Arg Arg Arg Glu Thr Arg Glu Ala Trp Asn Asn Val Thr Val 
        755                 760                 765             


Trp Gly Ser Arg Tyr Val Val Gly Gln Thr Pro Val Tyr Val Pro Tyr 
    770                 775                 780                 


Glu Ile Arg Val Gln Ala Glu Asn Asp Phe Gly Lys Gly Pro Glu Pro 
785                 790                 795                 800 


Glu Ser Val Ile Gly Tyr Ser Gly Glu Asp Tyr Pro Arg Ala Ala Pro 
                805                 810                 815     


Thr Glu Val Lys Val Arg Val Met Asn Ser Thr Ala Ile Ser Leu Gln 
            820                 825                 830         


Trp Asn Arg Val Tyr Ser Asp Thr Val Gln Gly Gln Leu Arg Glu Tyr 
        835                 840                 845             


Arg Ala Tyr Tyr Trp Arg Glu Ser Ser Leu Leu Lys Asn Leu Trp Val 
    850                 855                 860                 


Ser Gln Lys Arg Gln Gln Ala Ser Phe Pro Gly Asp Arg Leu Arg Gly 
865                 870                 875                 880 


Val Val Ser Arg Leu Phe Pro Tyr Ser Asn Tyr Lys Leu Glu Met Val 
                885                 890                 895     


Val Val Asn Gly Arg Gly Asp Gly Pro Arg Ser Glu Thr Lys Glu Phe 
            900                 905                 910         


Thr Thr Pro Glu Gly Val Pro Ser Ala Pro Arg Arg Phe Arg Val Arg 
        915                 920                 925             


Gln Pro Asn Leu Glu Thr Ile Asn Leu Glu Trp Asp His Pro Glu His 
    930                 935                 940                 


Pro Asn Gly Ile Met Ile Gly Tyr Thr Leu Lys Tyr Val Ala Phe Asn 
945                 950                 955                 960 


Gly Thr Lys Val Gly Lys Gln Ile Val Glu Asn Phe Ser Pro Asn Gln 
                965                 970                 975     


Thr Lys Phe Thr Val Gln Arg Thr Asp Pro Val Ser Arg Tyr Arg Phe 
            980                 985                 990         


Thr Leu Ser Ala Arg Thr Gln Val  Gly Ser Gly Glu Ala  Val Thr Glu 
        995                 1000                 1005             


Glu Ser  Pro Ala Pro Pro Asn  Glu Ala Thr Pro Thr  Ala Ala Tyr 
    1010                 1015                 1020             


Thr Asn  Asn Gln Ala Asp Ile  Ala Thr Gln Gly Trp  Phe Ile Gly 
    1025                 1030                 1035             


Leu Met  Cys Ala Ile Ala Leu  Leu Val Leu Ile Leu  Leu Ile Val 
    1040                 1045                 1050             


Cys Phe  Ile Lys Arg Ser Arg  Gly Gly Lys Tyr Pro  Val Arg Glu 
    1055                 1060                 1065             


Lys Lys  Asp Val Pro Leu Gly  Pro Glu Asp Pro Lys  Glu Glu Asp 
    1070                 1075                 1080             


Gly Ser  Phe Asp Tyr Ser Asp  Glu Asp Asn Lys Pro  Leu Gln Gly 
    1085                 1090                 1095             


Ser Gln  Thr Ser Leu Asp Gly  Thr Ile Lys Gln Gln  Glu Ser Asp 
    1100                 1105                 1110             


Asp Ser  Leu Val Asp Tyr Gly  Glu Gly Gly Glu Gly  Gln Phe Asn 
    1115                 1120                 1125             


Glu Asp  Gly Ser Phe Ile Gly  Gln Tyr Thr Val Lys  Lys Asp Lys 
    1130                 1135                 1140             


Glu Glu  Thr Glu Gly Asn Glu  Ser Ser Glu Ala Thr  Ser Pro Val 
    1145                 1150                 1155             


Asn Ala  Ile Tyr Ser Leu Ala  
    1160                 1165 


<210>  9314
<211>  1169
<212>  PRT
<213>  Homo Sapiens

<400>  9314

Met Ala Arg Gln Pro Pro Pro Pro Trp Val His Ala Ala Phe Leu Leu 
1               5                   10                  15      


Cys Leu Leu Ser Leu Gly Gly Ala Ile Glu Ile Pro Met Asp Leu Thr 
            20                  25                  30          


Gln Pro Pro Thr Ile Thr Lys Gln Ser Ala Lys Asp His Ile Val Asp 
        35                  40                  45              


Pro Arg Asp Asn Ile Leu Ile Glu Cys Glu Ala Lys Gly Asn Pro Ala 
    50                  55                  60                  


Pro Ser Phe His Trp Thr Arg Asn Ser Arg Phe Phe Asn Ile Ala Lys 
65                  70                  75                  80  


Asp Pro Arg Val Ser Met Arg Arg Arg Ser Gly Thr Leu Val Ile Asp 
                85                  90                  95      


Phe Arg Ser Gly Gly Arg Pro Glu Glu Tyr Glu Gly Glu Tyr Gln Cys 
            100                 105                 110         


Phe Ala Arg Asn Lys Phe Gly Thr Ala Leu Ser Asn Arg Ile Arg Leu 
        115                 120                 125             


Gln Val Ser Lys Ser Pro Leu Trp Pro Lys Glu Asn Leu Asp Pro Val 
    130                 135                 140                 


Val Val Gln Glu Gly Ala Pro Leu Thr Leu Gln Cys Asn Pro Pro Pro 
145                 150                 155                 160 


Gly Leu Pro Ser Pro Val Ile Phe Trp Met Ser Ser Ser Met Glu Pro 
                165                 170                 175     


Ile Thr Gln Asp Lys Arg Val Ser Gln Gly His Asn Gly Asp Leu Tyr 
            180                 185                 190         


Phe Ser Asn Val Met Leu Gln Asp Met Gln Thr Asp Tyr Ser Cys Asn 
        195                 200                 205             


Ala Arg Phe His Phe Thr His Thr Ile Gln Gln Lys Asn Pro Phe Thr 
    210                 215                 220                 


Leu Lys Val Leu Thr Asn His Pro Tyr Asn Asp Ser Ser Leu Arg Asn 
225                 230                 235                 240 


His Pro Asp Met Tyr Ser Ala Arg Gly Val Ala Glu Arg Thr Pro Ser 
                245                 250                 255     


Phe Met Tyr Pro Gln Gly Thr Ala Ser Ser Gln Met Val Leu Arg Gly 
            260                 265                 270         


Met Asp Leu Leu Leu Glu Cys Ile Ala Ser Gly Val Pro Thr Pro Asp 
        275                 280                 285             


Ile Ala Trp Tyr Lys Lys Gly Gly Asp Leu Pro Ser Asp Lys Ala Lys 
    290                 295                 300                 


Phe Glu Asn Phe Asn Lys Ala Leu Arg Ile Thr Asn Val Ser Glu Glu 
305                 310                 315                 320 


Asp Ser Gly Glu Tyr Phe Cys Leu Ala Ser Asn Lys Met Gly Ser Ile 
                325                 330                 335     


Arg His Thr Ile Ser Val Arg Val Lys Ala Ala Pro Tyr Trp Leu Asp 
            340                 345                 350         


Glu Pro Lys Asn Leu Ile Leu Ala Pro Gly Glu Asp Gly Arg Leu Val 
        355                 360                 365             


Cys Arg Ala Asn Gly Asn Pro Lys Pro Thr Val Gln Trp Met Val Asn 
    370                 375                 380                 


Gly Glu Pro Leu Gln Ser Ala Pro Pro Asn Pro Asn Arg Glu Val Ala 
385                 390                 395                 400 


Gly Asp Thr Ile Ile Phe Arg Asp Thr Gln Ile Ser Ser Arg Ala Val 
                405                 410                 415     


Tyr Gln Cys Asn Thr Ser Asn Glu His Gly Tyr Leu Leu Ala Asn Ala 
            420                 425                 430         


Phe Val Ser Val Leu Asp Val Pro Pro Arg Met Leu Ser Pro Arg Asn 
        435                 440                 445             


Gln Leu Ile Arg Val Ile Leu Tyr Asn Arg Thr Arg Leu Asp Cys Pro 
    450                 455                 460                 


Phe Phe Gly Ser Pro Ile Pro Thr Leu Arg Trp Phe Lys Asn Gly Gln 
465                 470                 475                 480 


Gly Ser Asn Leu Asp Gly Gly Asn Tyr His Val Tyr Glu Asn Gly Ser 
                485                 490                 495     


Leu Glu Ile Lys Met Ile Arg Lys Glu Asp Gln Gly Ile Tyr Thr Cys 
            500                 505                 510         


Val Ala Thr Asn Ile Leu Gly Lys Ala Glu Asn Gln Val Arg Leu Glu 
        515                 520                 525             


Val Lys Asp Pro Thr Arg Ile Tyr Arg Met Pro Glu Asp Gln Val Ala 
    530                 535                 540                 


Arg Arg Gly Thr Thr Val Gln Leu Glu Cys Arg Val Lys His Asp Pro 
545                 550                 555                 560 


Ser Leu Lys Leu Thr Val Ser Trp Leu Lys Asp Asp Glu Pro Leu Tyr 
                565                 570                 575     


Ile Gly Asn Arg Met Lys Lys Glu Asp Asp Ser Leu Thr Ile Phe Gly 
            580                 585                 590         


Val Ala Glu Arg Asp Gln Gly Ser Tyr Thr Cys Val Ala Ser Thr Glu 
        595                 600                 605             


Leu Asp Gln Asp Leu Ala Lys Ala Tyr Leu Thr Val Leu Gly Arg Pro 
    610                 615                 620                 


Asp Arg Pro Arg Asp Leu Glu Leu Thr Asp Leu Ala Glu Arg Ser Val 
625                 630                 635                 640 


Arg Leu Thr Trp Ile Pro Gly Asp Ala Asn Asn Ser Pro Ile Thr Asp 
                645                 650                 655     


Tyr Val Val Gln Phe Glu Glu Asp Gln Phe Gln Pro Gly Val Trp His 
            660                 665                 670         


Asp His Ser Lys Tyr Pro Gly Ser Val Asn Ser Ala Val Leu Arg Leu 
        675                 680                 685             


Ser Pro Tyr Val Asn Tyr Gln Phe Arg Val Ile Ala Ile Asn Glu Val 
    690                 695                 700                 


Gly Ser Ser His Pro Ser Leu Pro Ser Glu Arg Tyr Arg Thr Ser Gly 
705                 710                 715                 720 


Ala Pro Pro Glu Ser Asn Pro Gly Asp Val Lys Gly Glu Gly Thr Arg 
                725                 730                 735     


Lys Asn Asn Met Glu Ile Thr Trp Thr Pro Met Asn Ala Thr Ser Ala 
            740                 745                 750         


Phe Gly Pro Asn Leu Arg Tyr Ile Val Lys Trp Arg Arg Arg Glu Thr 
        755                 760                 765             


Arg Glu Ala Trp Asn Asn Val Thr Val Trp Gly Ser Arg Tyr Val Val 
    770                 775                 780                 


Gly Gln Thr Pro Val Tyr Val Pro Tyr Glu Ile Arg Val Gln Ala Glu 
785                 790                 795                 800 


Asn Asp Phe Gly Lys Gly Pro Glu Pro Glu Ser Val Ile Gly Tyr Ser 
                805                 810                 815     


Gly Glu Asp Tyr Pro Arg Ala Ala Pro Thr Glu Val Lys Val Arg Val 
            820                 825                 830         


Met Asn Ser Thr Ala Ile Ser Leu Gln Trp Asn Arg Val Tyr Ser Asp 
        835                 840                 845             


Thr Val Gln Gly Gln Leu Arg Glu Tyr Arg Ala Tyr Tyr Trp Arg Glu 
    850                 855                 860                 


Ser Ser Leu Leu Lys Asn Leu Trp Val Ser Gln Lys Arg Gln Gln Ala 
865                 870                 875                 880 


Ser Phe Pro Gly Asp Arg Leu Arg Gly Val Val Ser Arg Leu Phe Pro 
                885                 890                 895     


Tyr Ser Asn Tyr Lys Leu Glu Met Val Val Val Asn Gly Arg Gly Asp 
            900                 905                 910         


Gly Pro Arg Ser Glu Thr Lys Glu Phe Thr Thr Pro Glu Gly Val Pro 
        915                 920                 925             


Ser Ala Pro Arg Arg Phe Arg Val Arg Gln Pro Asn Leu Glu Thr Ile 
    930                 935                 940                 


Asn Leu Glu Trp Asp His Pro Glu His Pro Asn Gly Ile Met Ile Gly 
945                 950                 955                 960 


Tyr Thr Leu Lys Tyr Val Ala Phe Asn Gly Thr Lys Val Gly Lys Gln 
                965                 970                 975     


Ile Val Glu Asn Phe Ser Pro Asn Gln Thr Lys Phe Thr Val Gln Arg 
            980                 985                 990         


Thr Asp Pro Val Ser Arg Tyr Arg  Phe Thr Leu Ser Ala  Arg Thr Gln 
        995                 1000                 1005             


Val Gly  Ser Gly Glu Ala Val  Thr Glu Glu Ser Pro  Ala Pro Pro 
    1010                 1015                 1020             


Asn Glu  Ala Tyr Thr Asn Asn  Gln Ala Asp Ile Ala  Thr Gln Gly 
    1025                 1030                 1035             


Trp Phe  Ile Gly Leu Met Cys  Ala Ile Ala Leu Leu  Val Leu Ile 
    1040                 1045                 1050             


Leu Leu  Ile Val Cys Phe Ile  Lys Arg Ser Arg Gly  Gly Lys Tyr 
    1055                 1060                 1065             


Pro Val  Arg Glu Lys Lys Asp  Val Pro Leu Gly Pro  Glu Asp Pro 
    1070                 1075                 1080             


Lys Glu  Glu Asp Gly Ser Phe  Asp Tyr Ser Asp Glu  Asp Asn Lys 
    1085                 1090                 1095             


Pro Leu  Gln Gly Ser Gln Thr  Ser Leu Asp Gly Thr  Ile Lys Gln 
    1100                 1105                 1110             


Gln Glu  Ser Asp Asp Ser Leu  Val Asp Tyr Gly Glu  Gly Gly Glu 
    1115                 1120                 1125             


Gly Gln  Phe Asn Glu Asp Gly  Ser Phe Ile Gly Gln  Tyr Thr Val 
    1130                 1135                 1140             


Lys Lys  Asp Lys Glu Glu Thr  Glu Gly Asn Glu Ser  Ser Glu Ala 
    1145                 1150                 1155             


Thr Ser  Pro Val Asn Ala Ile  Tyr Ser Leu Ala 
    1160                 1165                 


<210>  9315
<211>  1174
<212>  PRT
<213>  Homo Sapiens

<400>  9315

Met Ala Arg Gln Pro Pro Pro Pro Trp Val His Ala Ala Phe Leu Leu 
1               5                   10                  15      


Cys Leu Leu Ser Leu Gly Gly Ala Ile Glu Ile Pro Met Asp Leu Thr 
            20                  25                  30          


Gln Pro Pro Thr Ile Thr Lys Gln Ser Ala Lys Asp His Ile Val Asp 
        35                  40                  45              


Pro Arg Asp Asn Ile Leu Ile Glu Cys Glu Ala Lys Gly Asn Pro Ala 
    50                  55                  60                  


Pro Ser Phe His Trp Thr Arg Asn Ser Arg Phe Phe Asn Ile Ala Lys 
65                  70                  75                  80  


Asp Pro Arg Val Ser Met Arg Arg Arg Ser Gly Thr Leu Val Ile Asp 
                85                  90                  95      


Phe Arg Ser Gly Gly Arg Pro Glu Glu Tyr Glu Gly Glu Tyr Gln Cys 
            100                 105                 110         


Phe Ala Arg Asn Lys Phe Gly Thr Ala Leu Ser Asn Arg Ile Arg Leu 
        115                 120                 125             


Gln Val Ser Lys Ser Pro Leu Trp Pro Lys Glu Asn Leu Asp Pro Val 
    130                 135                 140                 


Val Val Gln Glu Gly Ala Pro Leu Thr Leu Gln Cys Asn Pro Pro Pro 
145                 150                 155                 160 


Gly Leu Pro Ser Pro Val Ile Phe Trp Met Ser Ser Ser Met Glu Pro 
                165                 170                 175     


Ile Thr Gln Asp Lys Arg Val Ser Gln Gly His Asn Gly Asp Leu Tyr 
            180                 185                 190         


Phe Ser Asn Val Met Leu Gln Asp Met Gln Thr Asp Tyr Ser Cys Asn 
        195                 200                 205             


Ala Arg Phe His Phe Thr His Thr Ile Gln Gln Lys Asn Pro Phe Thr 
    210                 215                 220                 


Leu Lys Val Leu Thr Asn His Pro Tyr Asn Asp Ser Ser Leu Arg Asn 
225                 230                 235                 240 


His Pro Asp Met Tyr Ser Ala Arg Gly Val Ala Glu Arg Thr Pro Ser 
                245                 250                 255     


Phe Met Tyr Pro Gln Gly Thr Ala Ser Ser Gln Met Val Leu Arg Gly 
            260                 265                 270         


Met Asp Leu Leu Leu Glu Cys Ile Ala Ser Gly Val Pro Thr Pro Asp 
        275                 280                 285             


Ile Ala Trp Tyr Lys Lys Gly Gly Asp Leu Pro Ser Asp Lys Ala Lys 
    290                 295                 300                 


Phe Glu Asn Phe Asn Lys Ala Leu Arg Ile Thr Asn Val Ser Glu Glu 
305                 310                 315                 320 


Asp Ser Gly Glu Tyr Phe Cys Leu Ala Ser Asn Lys Met Gly Ser Ile 
                325                 330                 335     


Arg His Thr Ile Ser Val Arg Val Lys Ala Ala Pro Tyr Trp Leu Asp 
            340                 345                 350         


Glu Pro Lys Asn Leu Ile Leu Ala Pro Gly Glu Asp Gly Arg Leu Val 
        355                 360                 365             


Cys Arg Ala Asn Gly Asn Pro Lys Pro Thr Val Gln Trp Met Val Asn 
    370                 375                 380                 


Gly Glu Pro Leu Gln Ser Ala Pro Pro Asn Pro Asn Arg Glu Val Ala 
385                 390                 395                 400 


Gly Asp Thr Ile Ile Phe Arg Asp Thr Gln Ile Ser Ser Arg Ala Val 
                405                 410                 415     


Tyr Gln Cys Asn Thr Ser Asn Glu His Gly Tyr Leu Leu Ala Asn Ala 
            420                 425                 430         


Phe Val Ser Val Leu Asp Val Pro Pro Arg Met Leu Ser Pro Arg Asn 
        435                 440                 445             


Gln Leu Ile Arg Val Ile Leu Tyr Asn Arg Thr Arg Leu Asp Cys Pro 
    450                 455                 460                 


Phe Phe Gly Ser Pro Ile Pro Thr Leu Arg Trp Phe Lys Asn Gly Gln 
465                 470                 475                 480 


Gly Ser Asn Leu Asp Gly Gly Asn Tyr His Val Tyr Glu Asn Gly Ser 
                485                 490                 495     


Leu Glu Ile Lys Met Ile Arg Lys Glu Asp Gln Gly Ile Tyr Thr Cys 
            500                 505                 510         


Val Ala Thr Asn Ile Leu Gly Lys Ala Glu Asn Gln Val Arg Leu Glu 
        515                 520                 525             


Val Lys Asp Pro Thr Arg Ile Tyr Arg Met Pro Glu Asp Gln Val Ala 
    530                 535                 540                 


Arg Arg Gly Thr Thr Val Gln Leu Glu Cys Arg Val Lys His Asp Pro 
545                 550                 555                 560 


Ser Leu Lys Leu Thr Val Ser Trp Leu Lys Asp Asp Glu Pro Leu Tyr 
                565                 570                 575     


Ile Gly Asn Arg Met Lys Lys Glu Asp Asp Ser Leu Thr Ile Phe Gly 
            580                 585                 590         


Val Ala Glu Arg Asp Gln Gly Ser Tyr Thr Cys Val Ala Ser Thr Glu 
        595                 600                 605             


Leu Asp Gln Asp Leu Ala Lys Ala Tyr Leu Thr Val Leu Gly Arg Pro 
    610                 615                 620                 


Asp Arg Pro Arg Asp Leu Glu Leu Thr Asp Leu Ala Glu Arg Ser Val 
625                 630                 635                 640 


Arg Leu Thr Trp Ile Pro Gly Asp Ala Asn Asn Ser Pro Ile Thr Asp 
                645                 650                 655     


Tyr Val Val Gln Phe Glu Glu Asp Gln Phe Gln Pro Gly Val Trp His 
            660                 665                 670         


Asp His Ser Lys Tyr Pro Gly Ser Val Asn Ser Ala Val Leu Arg Leu 
        675                 680                 685             


Ser Pro Tyr Val Asn Tyr Gln Phe Arg Val Ile Ala Ile Asn Glu Val 
    690                 695                 700                 


Gly Ser Ser His Pro Ser Leu Pro Ser Glu Arg Tyr Arg Thr Ser Gly 
705                 710                 715                 720 


Ala Pro Pro Glu Ser Asn Pro Gly Asp Val Lys Gly Glu Gly Thr Arg 
                725                 730                 735     


Lys Asn Asn Met Glu Ile Thr Trp Thr Pro Met Asn Ala Thr Ser Ala 
            740                 745                 750         


Phe Gly Pro Asn Leu Arg Tyr Ile Val Lys Trp Arg Arg Arg Glu Thr 
        755                 760                 765             


Arg Glu Ala Trp Asn Asn Val Thr Val Trp Gly Ser Arg Tyr Val Val 
    770                 775                 780                 


Gly Gln Thr Pro Val Tyr Val Pro Tyr Glu Ile Arg Val Gln Ala Glu 
785                 790                 795                 800 


Asn Asp Phe Gly Lys Gly Pro Glu Pro Glu Ser Val Ile Gly Tyr Ser 
                805                 810                 815     


Gly Glu Asp Tyr Pro Arg Ala Ala Pro Thr Glu Val Lys Val Arg Val 
            820                 825                 830         


Met Asn Ser Thr Ala Ile Ser Leu Gln Trp Asn Arg Val Tyr Ser Asp 
        835                 840                 845             


Thr Val Gln Gly Gln Leu Arg Glu Tyr Arg Ala Tyr Tyr Trp Arg Glu 
    850                 855                 860                 


Ser Ser Leu Leu Lys Asn Leu Trp Val Ser Gln Lys Arg Gln Gln Ala 
865                 870                 875                 880 


Ser Phe Pro Gly Asp Arg Leu Arg Gly Val Val Ser Arg Leu Phe Pro 
                885                 890                 895     


Tyr Ser Asn Tyr Lys Leu Glu Met Val Val Val Asn Gly Arg Gly Asp 
            900                 905                 910         


Gly Pro Arg Ser Glu Thr Lys Glu Phe Thr Thr Pro Glu Gly Val Pro 
        915                 920                 925             


Ser Ala Pro Arg Arg Phe Arg Val Arg Gln Pro Asn Leu Glu Thr Ile 
    930                 935                 940                 


Asn Leu Glu Trp Asp His Pro Glu His Pro Asn Gly Ile Met Ile Gly 
945                 950                 955                 960 


Tyr Thr Leu Lys Tyr Val Ala Phe Asn Gly Thr Lys Val Gly Lys Gln 
                965                 970                 975     


Ile Val Glu Asn Phe Ser Pro Asn Gln Thr Lys Phe Thr Val Gln Arg 
            980                 985                 990         


Thr Asp Pro Val Ser Arg Tyr Arg  Phe Thr Leu Ser Ala  Arg Thr Gln 
        995                 1000                 1005             


Val Gly  Ser Gly Glu Ala Val  Thr Glu Glu Ser Pro  Ala Pro Pro 
    1010                 1015                 1020             


Asn Glu  Ala Thr Pro Thr Ala  Ala Tyr Thr Asn Asn  Gln Ala Asp 
    1025                 1030                 1035             


Ile Ala  Thr Gln Gly Trp Phe  Ile Gly Leu Met Cys  Ala Ile Ala 
    1040                 1045                 1050             


Leu Leu  Val Leu Ile Leu Leu  Ile Val Cys Phe Ile  Lys Arg Ser 
    1055                 1060                 1065             


Arg Gly  Gly Lys Tyr Pro Val  Arg Glu Lys Lys Asp  Val Pro Leu 
    1070                 1075                 1080             


Gly Pro  Glu Asp Pro Lys Glu  Glu Asp Gly Ser Phe  Asp Tyr Ser 
    1085                 1090                 1095             


Asp Glu  Asp Asn Lys Pro Leu  Gln Gly Ser Gln Thr  Ser Leu Asp 
    1100                 1105                 1110             


Gly Thr  Ile Lys Gln Gln Glu  Ser Asp Asp Ser Leu  Val Asp Tyr 
    1115                 1120                 1125             


Gly Glu  Gly Gly Glu Gly Gln  Phe Asn Glu Asp Gly  Ser Phe Ile 
    1130                 1135                 1140             


Gly Gln  Tyr Thr Val Lys Lys  Asp Lys Glu Glu Thr  Glu Gly Asn 
    1145                 1150                 1155             


Glu Ser  Ser Glu Ala Thr Ser  Pro Val Asn Ala Ile  Tyr Ser Leu 
    1160                 1165                 1170             


Ala 
    


<210>  9316
<211>  1174
<212>  PRT
<213>  Homo Sapiens

<400>  9316

Met Ala Arg Gln Pro Pro Pro Pro Trp Val His Ala Ala Phe Leu Leu 
1               5                   10                  15      


Cys Leu Leu Ser Leu Gly Gly Ala Ile Glu Ile Pro Met Asp Leu Thr 
            20                  25                  30          


Gln Pro Pro Thr Ile Thr Lys Gln Ser Ala Lys Asp His Ile Val Asp 
        35                  40                  45              


Pro Arg Asp Asn Ile Leu Ile Glu Cys Glu Ala Lys Gly Asn Pro Ala 
    50                  55                  60                  


Pro Ser Phe His Trp Thr Arg Asn Ser Arg Phe Phe Asn Ile Ala Lys 
65                  70                  75                  80  


Asp Pro Arg Val Ser Met Arg Arg Arg Ser Gly Thr Leu Val Ile Asp 
                85                  90                  95      


Phe Arg Ser Gly Gly Arg Pro Glu Glu Tyr Glu Gly Glu Tyr Gln Cys 
            100                 105                 110         


Phe Ala Arg Asn Lys Phe Gly Thr Ala Leu Ser Asn Arg Ile Arg Leu 
        115                 120                 125             


Gln Val Ser Lys Ser Pro Leu Trp Pro Lys Glu Asn Leu Asp Pro Val 
    130                 135                 140                 


Val Val Gln Glu Gly Ala Pro Leu Thr Leu Gln Cys Asn Pro Pro Pro 
145                 150                 155                 160 


Gly Leu Pro Ser Pro Val Ile Phe Trp Met Ser Ser Ser Met Glu Pro 
                165                 170                 175     


Ile Thr Gln Asp Lys Arg Val Ser Gln Gly His Asn Gly Asp Leu Tyr 
            180                 185                 190         


Phe Ser Asn Val Met Leu Gln Asp Met Gln Thr Asp Tyr Ser Cys Asn 
        195                 200                 205             


Ala Arg Phe His Phe Thr His Thr Ile Gln Gln Lys Asn Pro Phe Thr 
    210                 215                 220                 


Leu Lys Val Leu Thr Asn His Pro Tyr Asn Asp Ser Ser Leu Arg Asn 
225                 230                 235                 240 


His Pro Asp Met Tyr Ser Ala Arg Gly Val Ala Glu Arg Thr Pro Ser 
                245                 250                 255     


Phe Met Tyr Pro Gln Gly Thr Ala Ser Ser Gln Met Val Leu Arg Gly 
            260                 265                 270         


Met Asp Leu Leu Leu Glu Cys Ile Ala Ser Gly Val Pro Thr Pro Asp 
        275                 280                 285             


Ile Ala Trp Tyr Lys Lys Gly Gly Asp Leu Pro Ser Asp Lys Ala Lys 
    290                 295                 300                 


Phe Glu Asn Phe Asn Lys Ala Leu Arg Ile Thr Asn Val Ser Glu Glu 
305                 310                 315                 320 


Asp Ser Gly Glu Tyr Phe Cys Leu Ala Ser Asn Lys Met Gly Ser Ile 
                325                 330                 335     


Arg His Thr Ile Ser Val Arg Val Lys Ala Ala Pro Tyr Trp Leu Asp 
            340                 345                 350         


Glu Pro Lys Asn Leu Ile Leu Ala Pro Gly Glu Asp Gly Arg Leu Val 
        355                 360                 365             


Cys Arg Ala Asn Gly Asn Pro Lys Pro Thr Val Gln Trp Met Val Asn 
    370                 375                 380                 


Gly Glu Pro Leu Gln Ser Ala Pro Pro Asn Pro Asn Arg Glu Val Ala 
385                 390                 395                 400 


Gly Asp Thr Ile Ile Phe Arg Asp Thr Gln Ile Ser Ser Arg Ala Val 
                405                 410                 415     


Tyr Gln Cys Asn Thr Ser Asn Glu His Gly Tyr Leu Leu Ala Asn Ala 
            420                 425                 430         


Phe Val Ser Val Leu Asp Val Pro Pro Arg Met Leu Ser Pro Arg Asn 
        435                 440                 445             


Gln Leu Ile Arg Val Ile Leu Tyr Asn Arg Thr Arg Leu Asp Cys Pro 
    450                 455                 460                 


Phe Phe Gly Ser Pro Ile Pro Thr Leu Arg Trp Phe Lys Asn Gly Gln 
465                 470                 475                 480 


Gly Ser Asn Leu Asp Gly Gly Asn Tyr His Val Tyr Glu Asn Gly Ser 
                485                 490                 495     


Leu Glu Ile Lys Met Ile Arg Lys Glu Asp Gln Gly Ile Tyr Thr Cys 
            500                 505                 510         


Val Ala Thr Asn Ile Leu Gly Lys Ala Glu Asn Gln Val Arg Leu Glu 
        515                 520                 525             


Val Lys Asp Pro Thr Arg Ile Tyr Arg Met Pro Glu Asp Gln Val Ala 
    530                 535                 540                 


Arg Arg Gly Thr Thr Val Gln Leu Glu Cys Arg Val Lys His Asp Pro 
545                 550                 555                 560 


Ser Leu Lys Leu Thr Val Ser Trp Leu Lys Asp Asp Glu Pro Leu Tyr 
                565                 570                 575     


Ile Gly Asn Arg Met Lys Lys Glu Asp Asp Ser Leu Thr Ile Phe Gly 
            580                 585                 590         


Val Ala Glu Arg Asp Gln Gly Ser Tyr Thr Cys Val Ala Ser Thr Glu 
        595                 600                 605             


Leu Asp Gln Asp Leu Ala Lys Ala Tyr Leu Thr Val Leu Gly Arg Pro 
    610                 615                 620                 


Asp Arg Pro Arg Asp Leu Glu Leu Thr Asp Leu Ala Glu Arg Ser Val 
625                 630                 635                 640 


Arg Leu Thr Trp Ile Pro Gly Asp Ala Asn Asn Ser Pro Ile Thr Asp 
                645                 650                 655     


Tyr Val Val Gln Phe Glu Glu Asp Gln Phe Gln Pro Gly Val Trp His 
            660                 665                 670         


Asp His Ser Lys Tyr Pro Gly Ser Val Asn Ser Ala Val Leu Arg Leu 
        675                 680                 685             


Ser Pro Tyr Val Asn Tyr Gln Phe Arg Val Ile Ala Ile Asn Glu Val 
    690                 695                 700                 


Gly Ser Ser His Pro Ser Leu Pro Ser Glu Arg Tyr Arg Thr Ser Gly 
705                 710                 715                 720 


Ala Pro Pro Glu Ser Asn Pro Gly Asp Val Lys Gly Glu Gly Thr Arg 
                725                 730                 735     


Lys Asn Asn Met Glu Ile Thr Trp Thr Pro Met Asn Ala Thr Ser Ala 
            740                 745                 750         


Phe Gly Pro Asn Leu Arg Tyr Ile Val Lys Trp Arg Arg Arg Glu Thr 
        755                 760                 765             


Arg Glu Ala Trp Asn Asn Val Thr Val Trp Gly Ser Arg Tyr Val Val 
    770                 775                 780                 


Gly Gln Thr Pro Val Tyr Val Pro Tyr Glu Ile Arg Val Gln Ala Glu 
785                 790                 795                 800 


Asn Asp Phe Gly Lys Gly Pro Glu Pro Glu Ser Val Ile Gly Tyr Ser 
                805                 810                 815     


Gly Glu Asp Tyr Pro Arg Ala Ala Pro Thr Glu Val Lys Val Arg Val 
            820                 825                 830         


Met Asn Ser Thr Ala Ile Ser Leu Gln Trp Asn Arg Val Tyr Ser Asp 
        835                 840                 845             


Thr Val Gln Gly Gln Leu Arg Glu Tyr Arg Ala Tyr Tyr Trp Arg Glu 
    850                 855                 860                 


Ser Ser Leu Leu Lys Asn Leu Trp Val Ser Gln Lys Arg Gln Gln Ala 
865                 870                 875                 880 


Ser Phe Pro Gly Asp Arg Leu Arg Gly Val Val Ser Arg Leu Phe Pro 
                885                 890                 895     


Tyr Ser Asn Tyr Lys Leu Glu Met Val Val Val Asn Gly Arg Gly Asp 
            900                 905                 910         


Gly Pro Arg Ser Glu Thr Lys Glu Phe Thr Thr Pro Glu Gly Val Pro 
        915                 920                 925             


Ser Ala Pro Arg Arg Phe Arg Val Arg Gln Pro Asn Leu Glu Thr Ile 
    930                 935                 940                 


Asn Leu Glu Trp Asp His Pro Glu His Pro Asn Gly Ile Met Ile Gly 
945                 950                 955                 960 


Tyr Thr Leu Lys Tyr Val Ala Phe Asn Gly Thr Lys Val Gly Lys Gln 
                965                 970                 975     


Ile Val Glu Asn Phe Ser Pro Asn Gln Thr Lys Phe Thr Val Gln Arg 
            980                 985                 990         


Thr Asp Pro Val Ser Arg Tyr Arg  Phe Thr Leu Ser Ala  Arg Thr Gln 
        995                 1000                 1005             


Val Gly  Ser Gly Glu Ala Val  Thr Glu Glu Ser Pro  Ala Pro Pro 
    1010                 1015                 1020             


Asn Glu  Ala Thr Pro Thr Ala  Ala Tyr Thr Asn Asn  Gln Ala Asp 
    1025                 1030                 1035             


Ile Ala  Thr Gln Gly Trp Phe  Ile Gly Leu Met Cys  Ala Ile Ala 
    1040                 1045                 1050             


Leu Leu  Val Leu Ile Leu Leu  Ile Val Cys Phe Ile  Lys Arg Ser 
    1055                 1060                 1065             


Arg Gly  Gly Lys Tyr Pro Val  Arg Glu Lys Lys Asp  Val Pro Leu 
    1070                 1075                 1080             


Gly Pro  Glu Asp Pro Lys Glu  Glu Asp Gly Ser Phe  Asp Tyr Ser 
    1085                 1090                 1095             


Asp Glu  Asp Asn Lys Pro Leu  Gln Gly Ser Gln Thr  Ser Leu Asp 
    1100                 1105                 1110             


Gly Thr  Ile Lys Gln Gln Glu  Ser Asp Asp Ser Leu  Val Asp Tyr 
    1115                 1120                 1125             


Gly Glu  Gly Gly Glu Gly Gln  Phe Asn Glu Asp Gly  Ser Phe Ile 
    1130                 1135                 1140             


Gly Gln  Tyr Thr Val Lys Lys  Asp Lys Glu Glu Thr  Glu Gly Asn 
    1145                 1150                 1155             


Glu Ser  Ser Glu Ala Thr Ser  Pro Val Asn Ala Ile  Tyr Ser Leu 
    1160                 1165                 1170             


Ala 
    


<210>  9317
<211>  1169
<212>  PRT
<213>  Homo Sapiens

<400>  9317

Met Ala Arg Gln Pro Pro Pro Pro Trp Val His Ala Ala Phe Leu Leu 
1               5                   10                  15      


Cys Leu Leu Ser Leu Gly Gly Ala Ile Glu Ile Pro Met Asp Leu Thr 
            20                  25                  30          


Gln Pro Pro Thr Ile Thr Lys Gln Ser Ala Lys Asp His Ile Val Asp 
        35                  40                  45              


Pro Arg Asp Asn Ile Leu Ile Glu Cys Glu Ala Lys Gly Asn Pro Ala 
    50                  55                  60                  


Pro Ser Phe His Trp Thr Arg Asn Ser Arg Phe Phe Asn Ile Ala Lys 
65                  70                  75                  80  


Asp Pro Arg Val Ser Met Arg Arg Arg Ser Gly Thr Leu Val Ile Asp 
                85                  90                  95      


Phe Arg Ser Gly Gly Arg Pro Glu Glu Tyr Glu Gly Glu Tyr Gln Cys 
            100                 105                 110         


Phe Ala Arg Asn Lys Phe Gly Thr Ala Leu Ser Asn Arg Ile Arg Leu 
        115                 120                 125             


Gln Val Ser Lys Ser Pro Leu Trp Pro Lys Glu Asn Leu Asp Pro Val 
    130                 135                 140                 


Val Val Gln Glu Gly Ala Pro Leu Thr Leu Gln Cys Asn Pro Pro Pro 
145                 150                 155                 160 


Gly Leu Pro Ser Pro Val Ile Phe Trp Met Ser Ser Ser Met Glu Pro 
                165                 170                 175     


Ile Thr Gln Asp Lys Arg Val Ser Gln Gly His Asn Gly Asp Leu Tyr 
            180                 185                 190         


Phe Ser Asn Val Met Leu Gln Asp Met Gln Thr Asp Tyr Ser Cys Asn 
        195                 200                 205             


Ala Arg Phe His Phe Thr His Thr Ile Gln Gln Lys Asn Pro Phe Thr 
    210                 215                 220                 


Leu Lys Val Leu Thr Asn His Pro Tyr Asn Asp Ser Ser Leu Arg Asn 
225                 230                 235                 240 


His Pro Asp Met Tyr Ser Ala Arg Gly Val Ala Glu Arg Thr Pro Ser 
                245                 250                 255     


Phe Met Tyr Pro Gln Gly Thr Ala Ser Ser Gln Met Val Leu Arg Gly 
            260                 265                 270         


Met Asp Leu Leu Leu Glu Cys Ile Ala Ser Gly Val Pro Thr Pro Asp 
        275                 280                 285             


Ile Ala Trp Tyr Lys Lys Gly Gly Asp Leu Pro Ser Asp Lys Ala Lys 
    290                 295                 300                 


Phe Glu Asn Phe Asn Lys Ala Leu Arg Ile Thr Asn Val Ser Glu Glu 
305                 310                 315                 320 


Asp Ser Gly Glu Tyr Phe Cys Leu Ala Ser Asn Lys Met Gly Ser Ile 
                325                 330                 335     


Arg His Thr Ile Ser Val Arg Val Lys Ala Ala Pro Tyr Trp Leu Asp 
            340                 345                 350         


Glu Pro Lys Asn Leu Ile Leu Ala Pro Gly Glu Asp Gly Arg Leu Val 
        355                 360                 365             


Cys Arg Ala Asn Gly Asn Pro Lys Pro Thr Val Gln Trp Met Val Asn 
    370                 375                 380                 


Gly Glu Pro Leu Gln Ser Ala Pro Pro Asn Pro Asn Arg Glu Val Ala 
385                 390                 395                 400 


Gly Asp Thr Ile Ile Phe Arg Asp Thr Gln Ile Ser Ser Arg Ala Val 
                405                 410                 415     


Tyr Gln Cys Asn Thr Ser Asn Glu His Gly Tyr Leu Leu Ala Asn Ala 
            420                 425                 430         


Phe Val Ser Val Leu Asp Val Pro Pro Arg Met Leu Ser Pro Arg Asn 
        435                 440                 445             


Gln Leu Ile Arg Val Ile Leu Tyr Asn Arg Thr Arg Leu Asp Cys Pro 
    450                 455                 460                 


Phe Phe Gly Ser Pro Ile Pro Thr Leu Arg Trp Phe Lys Asn Gly Gln 
465                 470                 475                 480 


Gly Ser Asn Leu Asp Gly Gly Asn Tyr His Val Tyr Glu Asn Gly Ser 
                485                 490                 495     


Leu Glu Ile Lys Met Ile Arg Lys Glu Asp Gln Gly Ile Tyr Thr Cys 
            500                 505                 510         


Val Ala Thr Asn Ile Leu Gly Lys Ala Glu Asn Gln Val Arg Leu Glu 
        515                 520                 525             


Val Lys Asp Pro Thr Arg Ile Tyr Arg Met Pro Glu Asp Gln Val Ala 
    530                 535                 540                 


Arg Arg Gly Thr Thr Val Gln Leu Glu Cys Arg Val Lys His Asp Pro 
545                 550                 555                 560 


Ser Leu Lys Leu Thr Val Ser Trp Leu Lys Asp Asp Glu Pro Leu Tyr 
                565                 570                 575     


Ile Gly Asn Arg Met Lys Lys Glu Asp Asp Ser Leu Thr Ile Phe Gly 
            580                 585                 590         


Val Ala Glu Arg Asp Gln Gly Ser Tyr Thr Cys Val Ala Ser Thr Glu 
        595                 600                 605             


Leu Asp Gln Asp Leu Ala Lys Ala Tyr Leu Thr Val Leu Gly Arg Pro 
    610                 615                 620                 


Asp Arg Pro Arg Asp Leu Glu Leu Thr Asp Leu Ala Glu Arg Ser Val 
625                 630                 635                 640 


Arg Leu Thr Trp Ile Pro Gly Asp Ala Asn Asn Ser Pro Ile Thr Asp 
                645                 650                 655     


Tyr Val Val Gln Phe Glu Glu Asp Gln Phe Gln Pro Gly Val Trp His 
            660                 665                 670         


Asp His Ser Lys Tyr Pro Gly Ser Val Asn Ser Ala Val Leu Arg Leu 
        675                 680                 685             


Ser Pro Tyr Val Asn Tyr Gln Phe Arg Val Ile Ala Ile Asn Glu Val 
    690                 695                 700                 


Gly Ser Ser His Pro Ser Leu Pro Ser Glu Arg Tyr Arg Thr Ser Gly 
705                 710                 715                 720 


Ala Pro Pro Glu Ser Asn Pro Gly Asp Val Lys Gly Glu Gly Thr Arg 
                725                 730                 735     


Lys Asn Asn Met Glu Ile Thr Trp Thr Pro Met Asn Ala Thr Ser Ala 
            740                 745                 750         


Phe Gly Pro Asn Leu Arg Tyr Ile Val Lys Trp Arg Arg Arg Glu Thr 
        755                 760                 765             


Arg Glu Ala Trp Asn Asn Val Thr Val Trp Gly Ser Arg Tyr Val Val 
    770                 775                 780                 


Gly Gln Thr Pro Val Tyr Val Pro Tyr Glu Ile Arg Val Gln Ala Glu 
785                 790                 795                 800 


Asn Asp Phe Gly Lys Gly Pro Glu Pro Glu Ser Val Ile Gly Tyr Ser 
                805                 810                 815     


Gly Glu Asp Tyr Pro Arg Ala Ala Pro Thr Glu Val Lys Val Arg Val 
            820                 825                 830         


Met Asn Ser Thr Ala Ile Ser Leu Gln Trp Asn Arg Val Tyr Ser Asp 
        835                 840                 845             


Thr Val Gln Gly Gln Leu Arg Glu Tyr Arg Ala Tyr Tyr Trp Arg Glu 
    850                 855                 860                 


Ser Ser Leu Leu Lys Asn Leu Trp Val Ser Gln Lys Arg Gln Gln Ala 
865                 870                 875                 880 


Ser Phe Pro Gly Asp Arg Leu Arg Gly Val Val Ser Arg Leu Phe Pro 
                885                 890                 895     


Tyr Ser Asn Tyr Lys Leu Glu Met Val Val Val Asn Gly Arg Gly Asp 
            900                 905                 910         


Gly Pro Arg Ser Glu Thr Lys Glu Phe Thr Thr Pro Glu Gly Val Pro 
        915                 920                 925             


Ser Ala Pro Arg Arg Phe Arg Val Arg Gln Pro Asn Leu Glu Thr Ile 
    930                 935                 940                 


Asn Leu Glu Trp Asp His Pro Glu His Pro Asn Gly Ile Met Ile Gly 
945                 950                 955                 960 


Tyr Thr Leu Lys Tyr Val Ala Phe Asn Gly Thr Lys Val Gly Lys Gln 
                965                 970                 975     


Ile Val Glu Asn Phe Ser Pro Asn Gln Thr Lys Phe Thr Val Gln Arg 
            980                 985                 990         


Thr Asp Pro Val Ser Arg Tyr Arg  Phe Thr Leu Ser Ala  Arg Thr Gln 
        995                 1000                 1005             


Val Gly  Ser Gly Glu Ala Val  Thr Glu Glu Ser Pro  Ala Pro Pro 
    1010                 1015                 1020             


Asn Glu  Ala Tyr Thr Asn Asn  Gln Ala Asp Ile Ala  Thr Gln Gly 
    1025                 1030                 1035             


Trp Phe  Ile Gly Leu Met Cys  Ala Ile Ala Leu Leu  Val Leu Ile 
    1040                 1045                 1050             


Leu Leu  Ile Val Cys Phe Ile  Lys Arg Ser Arg Gly  Gly Lys Tyr 
    1055                 1060                 1065             


Pro Val  Arg Glu Lys Lys Asp  Val Pro Leu Gly Pro  Glu Asp Pro 
    1070                 1075                 1080             


Lys Glu  Glu Asp Gly Ser Phe  Asp Tyr Ser Asp Glu  Asp Asn Lys 
    1085                 1090                 1095             


Pro Leu  Gln Gly Ser Gln Thr  Ser Leu Asp Gly Thr  Ile Lys Gln 
    1100                 1105                 1110             


Gln Glu  Ser Asp Asp Ser Leu  Val Asp Tyr Gly Glu  Gly Gly Glu 
    1115                 1120                 1125             


Gly Gln  Phe Asn Glu Asp Gly  Ser Phe Ile Gly Gln  Tyr Thr Val 
    1130                 1135                 1140             


Lys Lys  Asp Lys Glu Glu Thr  Glu Gly Asn Glu Ser  Ser Glu Ala 
    1145                 1150                 1155             


Thr Ser  Pro Val Asn Ala Ile  Tyr Ser Leu Ala 
    1160                 1165                 


<210>  9318
<211>  1157
<212>  PRT
<213>  Homo Sapiens

<400>  9318

Met Ala Arg Gln Pro Pro Pro Pro Trp Val His Ala Ala Phe Leu Leu 
1               5                   10                  15      


Cys Leu Leu Ser Leu Gly Gly Ala Ile Glu Ile Pro Met Asp Leu Thr 
            20                  25                  30          


Gln Pro Pro Thr Ile Thr Lys Gln Ser Ala Lys Asp His Ile Val Asp 
        35                  40                  45              


Pro Arg Asp Asn Ile Leu Ile Glu Cys Glu Ala Lys Gly Asn Pro Ala 
    50                  55                  60                  


Pro Ser Phe His Trp Thr Arg Asn Ser Arg Phe Phe Asn Ile Ala Lys 
65                  70                  75                  80  


Asp Pro Arg Val Ser Met Arg Arg Arg Ser Gly Thr Leu Val Ile Asp 
                85                  90                  95      


Phe Arg Ser Gly Gly Arg Pro Glu Glu Tyr Glu Gly Glu Tyr Gln Cys 
            100                 105                 110         


Phe Ala Arg Asn Lys Phe Gly Thr Ala Leu Ser Asn Arg Ile Arg Leu 
        115                 120                 125             


Gln Val Ser Lys Ser Pro Leu Trp Pro Lys Glu Asn Leu Asp Pro Val 
    130                 135                 140                 


Val Val Gln Glu Gly Ala Pro Leu Thr Leu Gln Cys Asn Pro Pro Pro 
145                 150                 155                 160 


Gly Leu Pro Ser Pro Val Ile Phe Trp Met Ser Ser Ser Met Glu Pro 
                165                 170                 175     


Ile Thr Gln Asp Lys Arg Val Ser Gln Gly His Asn Gly Asp Leu Tyr 
            180                 185                 190         


Phe Ser Asn Val Met Leu Gln Asp Met Gln Thr Asp Tyr Ser Cys Asn 
        195                 200                 205             


Ala Arg Phe His Phe Thr His Thr Ile Gln Gln Lys Asn Pro Phe Thr 
    210                 215                 220                 


Leu Lys Val Leu Thr Thr Arg Gly Val Ala Glu Arg Thr Pro Ser Phe 
225                 230                 235                 240 


Met Tyr Pro Gln Gly Thr Ala Ser Ser Gln Met Val Leu Arg Gly Met 
                245                 250                 255     


Asp Leu Leu Leu Glu Cys Ile Ala Ser Gly Val Pro Thr Pro Asp Ile 
            260                 265                 270         


Ala Trp Tyr Lys Lys Gly Gly Asp Leu Pro Ser Asp Lys Ala Lys Phe 
        275                 280                 285             


Glu Asn Phe Asn Lys Ala Leu Arg Ile Thr Asn Val Ser Glu Glu Asp 
    290                 295                 300                 


Ser Gly Glu Tyr Phe Cys Leu Ala Ser Asn Lys Met Gly Ser Ile Arg 
305                 310                 315                 320 


His Thr Ile Ser Val Arg Val Lys Ala Ala Pro Tyr Trp Leu Asp Glu 
                325                 330                 335     


Pro Lys Asn Leu Ile Leu Ala Pro Gly Glu Asp Gly Arg Leu Val Cys 
            340                 345                 350         


Arg Ala Asn Gly Asn Pro Lys Pro Thr Val Gln Trp Met Val Asn Gly 
        355                 360                 365             


Glu Pro Leu Gln Ser Ala Pro Pro Asn Pro Asn Arg Glu Val Ala Gly 
    370                 375                 380                 


Asp Thr Ile Ile Phe Arg Asp Thr Gln Ile Ser Ser Arg Ala Val Tyr 
385                 390                 395                 400 


Gln Cys Asn Thr Ser Asn Glu His Gly Tyr Leu Leu Ala Asn Ala Phe 
                405                 410                 415     


Val Ser Val Leu Asp Val Pro Pro Arg Met Leu Ser Pro Arg Asn Gln 
            420                 425                 430         


Leu Ile Arg Val Ile Leu Tyr Asn Arg Thr Arg Leu Asp Cys Pro Phe 
        435                 440                 445             


Phe Gly Ser Pro Ile Pro Thr Leu Arg Trp Phe Lys Asn Gly Gln Gly 
    450                 455                 460                 


Ser Asn Leu Asp Gly Gly Asn Tyr His Val Tyr Glu Asn Gly Ser Leu 
465                 470                 475                 480 


Glu Ile Lys Met Ile Arg Lys Glu Asp Gln Gly Ile Tyr Thr Cys Val 
                485                 490                 495     


Ala Thr Asn Ile Leu Gly Lys Ala Glu Asn Gln Val Arg Leu Glu Val 
            500                 505                 510         


Lys Asp Pro Thr Arg Ile Tyr Arg Met Pro Glu Asp Gln Val Ala Arg 
        515                 520                 525             


Arg Gly Thr Thr Val Gln Leu Glu Cys Arg Val Lys His Asp Pro Ser 
    530                 535                 540                 


Leu Lys Leu Thr Val Ser Trp Leu Lys Asp Asp Glu Pro Leu Tyr Ile 
545                 550                 555                 560 


Gly Asn Arg Met Lys Lys Glu Asp Asp Ser Leu Thr Ile Phe Gly Val 
                565                 570                 575     


Ala Glu Arg Asp Gln Gly Ser Tyr Thr Cys Val Ala Ser Thr Glu Leu 
            580                 585                 590         


Asp Gln Asp Leu Ala Lys Ala Tyr Leu Thr Val Leu Gly Arg Pro Asp 
        595                 600                 605             


Arg Pro Arg Asp Leu Glu Leu Thr Asp Leu Ala Glu Arg Ser Val Arg 
    610                 615                 620                 


Leu Thr Trp Ile Pro Gly Asp Ala Asn Asn Ser Pro Ile Thr Asp Tyr 
625                 630                 635                 640 


Val Val Gln Phe Glu Glu Asp Gln Phe Gln Pro Gly Val Trp His Asp 
                645                 650                 655     


His Ser Lys Tyr Pro Gly Ser Val Asn Ser Ala Val Leu Arg Leu Ser 
            660                 665                 670         


Pro Tyr Val Asn Tyr Gln Phe Arg Val Ile Ala Ile Asn Glu Val Gly 
        675                 680                 685             


Ser Ser His Pro Ser Leu Pro Ser Glu Arg Tyr Arg Thr Ser Gly Ala 
    690                 695                 700                 


Pro Pro Glu Ser Asn Pro Gly Asp Val Lys Gly Glu Gly Thr Arg Lys 
705                 710                 715                 720 


Asn Asn Met Glu Ile Thr Trp Thr Pro Met Asn Ala Thr Ser Ala Phe 
                725                 730                 735     


Gly Pro Asn Leu Arg Tyr Ile Val Lys Trp Arg Arg Arg Glu Thr Arg 
            740                 745                 750         


Glu Ala Trp Asn Asn Val Thr Val Trp Gly Ser Arg Tyr Val Val Gly 
        755                 760                 765             


Gln Thr Pro Val Tyr Val Pro Tyr Glu Ile Arg Val Gln Ala Glu Asn 
    770                 775                 780                 


Asp Phe Gly Lys Gly Pro Glu Pro Glu Ser Val Ile Gly Tyr Ser Gly 
785                 790                 795                 800 


Glu Asp Tyr Pro Arg Ala Ala Pro Thr Glu Val Lys Val Arg Val Met 
                805                 810                 815     


Asn Ser Thr Ala Ile Ser Leu Gln Trp Asn Arg Val Tyr Ser Asp Thr 
            820                 825                 830         


Val Gln Gly Gln Leu Arg Glu Tyr Arg Ala Tyr Tyr Trp Arg Glu Ser 
        835                 840                 845             


Ser Leu Leu Lys Asn Leu Trp Val Ser Gln Lys Arg Gln Gln Ala Ser 
    850                 855                 860                 


Phe Pro Gly Asp Arg Leu Arg Gly Val Val Ser Arg Leu Phe Pro Tyr 
865                 870                 875                 880 


Ser Asn Tyr Lys Leu Glu Met Val Val Val Asn Gly Arg Gly Asp Gly 
                885                 890                 895     


Pro Arg Ser Glu Thr Lys Glu Phe Thr Thr Pro Glu Gly Val Pro Ser 
            900                 905                 910         


Ala Pro Arg Arg Phe Arg Val Arg Gln Pro Asn Leu Glu Thr Ile Asn 
        915                 920                 925             


Leu Glu Trp Asp His Pro Glu His Pro Asn Gly Ile Met Ile Gly Tyr 
    930                 935                 940                 


Thr Leu Lys Tyr Val Ala Phe Asn Gly Thr Lys Val Gly Lys Gln Ile 
945                 950                 955                 960 


Val Glu Asn Phe Ser Pro Asn Gln Thr Lys Phe Thr Val Gln Arg Thr 
                965                 970                 975     


Asp Pro Val Ser Arg Tyr Arg Phe Thr Leu Ser Ala Arg Thr Gln Val 
            980                 985                 990         


Gly Ser Gly Glu Ala Val Thr Glu  Glu Ser Pro Ala Pro  Pro Asn Glu 
        995                 1000                 1005             


Ala Thr  Pro Thr Ala Ala Tyr  Thr Asn Asn Gln Ala  Asp Ile Ala 
    1010                 1015                 1020             


Thr Gln  Gly Trp Phe Ile Gly  Leu Met Cys Ala Ile  Ala Leu Leu 
    1025                 1030                 1035             


Val Leu  Ile Leu Leu Ile Val  Cys Phe Ile Lys Arg  Ser Arg Gly 
    1040                 1045                 1050             


Gly Lys  Tyr Pro Val Arg Glu  Lys Lys Asp Val Pro  Leu Gly Pro 
    1055                 1060                 1065             


Glu Asp  Pro Lys Glu Glu Asp  Gly Ser Phe Asp Tyr  Ser Asp Glu 
    1070                 1075                 1080             


Asp Asn  Lys Pro Leu Gln Gly  Ser Gln Thr Ser Leu  Asp Gly Thr 
    1085                 1090                 1095             


Ile Lys  Gln Gln Glu Ser Asp  Asp Ser Leu Val Asp  Tyr Gly Glu 
    1100                 1105                 1110             


Gly Gly  Glu Gly Gln Phe Asn  Glu Asp Gly Ser Phe  Ile Gly Gln 
    1115                 1120                 1125             


Tyr Thr  Val Lys Lys Asp Lys  Glu Glu Thr Glu Gly  Asn Glu Ser 
    1130                 1135                 1140             


Ser Glu  Ala Thr Ser Pro Val  Asn Ala Ile Tyr Ser  Leu Ala 
    1145                 1150                 1155         


<210>  9319
<211>  129
<212>  PRT
<213>  Homo Sapiens

<400>  9319

Met Ala Arg Gln Pro Pro Pro Pro Trp Val His Ala Ala Phe Leu Leu 
1               5                   10                  15      


Cys Leu Leu Ser Leu Gly Gly Ala Ile Glu Ile Pro Met Asp Pro Ser 
            20                  25                  30          


Ile Gln Asn Glu Leu Thr Gln Pro Pro Thr Ile Thr Lys Gln Ser Ala 
        35                  40                  45              


Lys Asp His Ile Val Asp Pro Arg Asp Asn Ile Leu Ile Glu Cys Glu 
    50                  55                  60                  


Ala Lys Gly Asn Pro Ala Pro Ser Phe His Trp Thr Arg Asn Ser Arg 
65                  70                  75                  80  


Phe Phe Asn Ile Ala Lys Asp Pro Arg Val Ser Met Arg Arg Arg Ser 
                85                  90                  95      


Gly Thr Leu Val Ile Asp Phe Arg Ser Gly Gly Arg Pro Glu Glu Tyr 
            100                 105                 110         


Glu Gly Glu Tyr Gln Cys Phe Ala Arg Asn Lys Phe Gly Thr Ala Leu 
        115                 120                 125             


Ser 
    


<210>  9320
<211>  486
<212>  PRT
<213>  Homo Sapiens

<400>  9320

Met Ala Arg Gln Pro Pro Pro Pro Trp Val His Ala Ala Phe Leu Leu 
1               5                   10                  15      


Cys Leu Leu Ser Leu Gly Gly Ala Ile Glu Ile Pro Met Asp Pro Ser 
            20                  25                  30          


Ile Gln Asn Glu Leu Thr Gln Pro Pro Thr Ile Thr Lys Gln Ser Ala 
        35                  40                  45              


Lys Asp His Ile Val Asp Pro Arg Asp Asn Ile Leu Ile Glu Cys Glu 
    50                  55                  60                  


Ala Lys Gly Asn Pro Ala Pro Ser Phe His Trp Thr Arg Asn Ser Arg 
65                  70                  75                  80  


Phe Phe Asn Ile Ala Lys Asp Pro Arg Val Ser Met Arg Arg Arg Ser 
                85                  90                  95      


Gly Thr Leu Val Ile Asp Phe Arg Ser Gly Gly Arg Pro Glu Glu Tyr 
            100                 105                 110         


Glu Gly Glu Tyr Gln Cys Phe Ala Arg Asn Lys Phe Gly Thr Ala Leu 
        115                 120                 125             


Ser Asn Arg Ile Arg Leu Gln Val Ser Lys Ser Pro Leu Trp Pro Lys 
    130                 135                 140                 


Glu Asn Leu Asp Pro Val Val Val Gln Glu Gly Ala Pro Leu Thr Leu 
145                 150                 155                 160 


Gln Cys Asn Pro Pro Pro Gly Leu Pro Ser Pro Val Ile Phe Trp Met 
                165                 170                 175     


Ser Ser Ser Met Glu Pro Ile Thr Gln Asp Lys Arg Val Ser Gln Gly 
            180                 185                 190         


His Asn Gly Asp Leu Tyr Phe Ser Asn Val Met Leu Gln Asp Met Gln 
        195                 200                 205             


Thr Asp Tyr Ser Cys Asn Ala Arg Phe His Phe Thr His Thr Ile Gln 
    210                 215                 220                 


Gln Lys Asn Pro Phe Thr Leu Lys Val Leu Thr Asn His Pro Tyr Asn 
225                 230                 235                 240 


Asp Ser Ser Leu Arg Asn His Pro Asp Met Tyr Ser Ala Arg Gly Val 
                245                 250                 255     


Ala Glu Arg Thr Pro Ser Phe Met Tyr Pro Gln Gly Thr Ala Ser Ser 
            260                 265                 270         


Gln Met Val Leu Arg Gly Met Asp Leu Leu Leu Glu Cys Ile Ala Ser 
        275                 280                 285             


Gly Val Pro Thr Pro Asp Ile Ala Trp Tyr Lys Lys Gly Gly Asp Leu 
    290                 295                 300                 


Pro Ser Asp Lys Ala Lys Phe Glu Asn Phe Asn Lys Ala Leu Arg Ile 
305                 310                 315                 320 


Thr Asn Val Ser Glu Glu Asp Ser Gly Glu Tyr Phe Cys Leu Ala Ser 
                325                 330                 335     


Asn Lys Met Gly Ser Ile Arg His Thr Ile Ser Val Arg Val Lys Ala 
            340                 345                 350         


Ala Pro Tyr Trp Leu Asp Glu Pro Lys Asn Leu Ile Leu Ala Pro Gly 
        355                 360                 365             


Glu Asp Gly Arg Leu Val Cys Arg Ala Asn Gly Asn Pro Lys Pro Thr 
    370                 375                 380                 


Val Gln Trp Met Val Asn Gly Glu Pro Leu Gln Ser Ala Pro Pro Asn 
385                 390                 395                 400 


Pro Asn Arg Glu Val Ala Gly Asp Thr Ile Ile Phe Arg Asp Thr Gln 
                405                 410                 415     


Ile Ser Ser Arg Ala Val Tyr Gln Cys Asn Thr Ser Asn Glu His Gly 
            420                 425                 430         


Tyr Leu Leu Ala Asn Ala Phe Val Ser Val Leu Asp Val Pro Pro Arg 
        435                 440                 445             


Met Leu Ser Pro Arg Asn Gln Leu Ile Arg Val Ile Leu Tyr Asn Arg 
    450                 455                 460                 


Thr Arg Leu Asp Cys Pro Phe Phe Gly Ser Pro Ile Pro Thr Leu Arg 
465                 470                 475                 480 


Cys Pro His Gly Leu Ser 
                485     


<210>  9321
<211>  1240
<212>  PRT
<213>  Homo Sapiens

<400>  9321

Met Ala Arg Gln Pro Pro Pro Pro Trp Val His Ala Ala Phe Leu Leu 
1               5                   10                  15      


Cys Leu Leu Ser Leu Gly Gly Ala Ile Glu Ile Pro Met Asp Pro Ser 
            20                  25                  30          


Ile Gln Asn Glu Leu Thr Gln Pro Pro Thr Ile Thr Lys Gln Ser Ala 
        35                  40                  45              


Lys Asp His Ile Val Asp Pro Arg Asp Asn Ile Leu Ile Glu Cys Glu 
    50                  55                  60                  


Ala Lys Gly Asn Pro Ala Pro Ser Phe His Trp Thr Arg Asn Ser Arg 
65                  70                  75                  80  


Phe Phe Asn Ile Ala Lys Asp Pro Arg Val Ser Met Arg Arg Arg Ser 
                85                  90                  95      


Gly Thr Leu Val Ile Asp Phe Arg Ser Gly Gly Arg Pro Glu Glu Tyr 
            100                 105                 110         


Glu Gly Glu Tyr Gln Cys Phe Ala Arg Asn Lys Phe Gly Thr Ala Leu 
        115                 120                 125             


Ser Asn Arg Ile Arg Leu Gln Val Ser Lys Ser Pro Leu Trp Pro Lys 
    130                 135                 140                 


Glu Asn Leu Asp Pro Val Val Val Gln Glu Gly Ala Pro Leu Thr Leu 
145                 150                 155                 160 


Gln Cys Asn Pro Pro Pro Gly Leu Pro Ser Pro Val Ile Phe Trp Met 
                165                 170                 175     


Ser Ser Ser Met Glu Pro Ile Thr Gln Asp Lys Arg Val Ser Gln Gly 
            180                 185                 190         


His Asn Gly Asp Leu Tyr Phe Ser Asn Val Met Leu Gln Asp Met Gln 
        195                 200                 205             


Thr Asp Tyr Ser Cys Asn Ala Arg Phe His Phe Thr His Thr Ile Gln 
    210                 215                 220                 


Gln Lys Asn Pro Phe Thr Leu Lys Val Leu Thr Thr Arg Gly Val Ala 
225                 230                 235                 240 


Glu Arg Thr Pro Ser Phe Met Tyr Pro Gln Gly Thr Ala Ser Ser Gln 
                245                 250                 255     


Met Val Leu Arg Gly Met Asp Leu Leu Leu Glu Cys Ile Ala Ser Gly 
            260                 265                 270         


Val Pro Thr Pro Asp Ile Ala Trp Tyr Lys Lys Gly Gly Asp Leu Pro 
        275                 280                 285             


Ser Asp Lys Ala Lys Phe Glu Asn Phe Asn Lys Ala Leu Arg Ile Thr 
    290                 295                 300                 


Asn Val Ser Glu Glu Asp Ser Gly Glu Tyr Phe Cys Leu Ala Ser Asn 
305                 310                 315                 320 


Lys Met Gly Ser Ile Arg His Thr Ile Ser Val Arg Val Lys Ala Ala 
                325                 330                 335     


Pro Tyr Trp Leu Asp Glu Pro Lys Asn Leu Ile Leu Ala Pro Gly Glu 
            340                 345                 350         


Asp Gly Arg Leu Val Cys Arg Ala Asn Gly Asn Pro Lys Pro Thr Val 
        355                 360                 365             


Gln Trp Met Val Asn Gly Glu Pro Leu Gln Ser Ala Pro Pro Asn Pro 
    370                 375                 380                 


Asn Arg Glu Val Ala Gly Asp Thr Ile Ile Phe Arg Asp Thr Gln Ile 
385                 390                 395                 400 


Ser Ser Arg Ala Val Tyr Gln Cys Asn Thr Ser Asn Glu His Gly Tyr 
                405                 410                 415     


Leu Leu Ala Asn Ala Phe Val Ser Val Leu Asp Val Pro Pro Arg Met 
            420                 425                 430         


Leu Ser Pro Arg Asn Gln Leu Ile Arg Val Ile Leu Tyr Asn Arg Thr 
        435                 440                 445             


Arg Leu Asp Cys Pro Phe Phe Gly Ser Pro Ile Pro Thr Leu Arg Trp 
    450                 455                 460                 


Phe Lys Asn Gly Gln Gly Ser Asn Leu Asp Gly Gly Asn Tyr His Val 
465                 470                 475                 480 


Tyr Glu Asn Gly Ser Leu Glu Ile Lys Met Ile Arg Lys Glu Asp Gln 
                485                 490                 495     


Gly Ile Tyr Thr Cys Val Ala Thr Asn Ile Leu Gly Lys Ala Glu Asn 
            500                 505                 510         


Gln Val Arg Leu Glu Val Lys Asp Pro Thr Arg Ile Tyr Arg Met Pro 
        515                 520                 525             


Glu Asp Gln Val Ala Arg Arg Gly Thr Thr Val Gln Leu Glu Cys Arg 
    530                 535                 540                 


Val Lys His Asp Pro Ser Leu Lys Leu Thr Val Ser Trp Leu Lys Asp 
545                 550                 555                 560 


Asp Glu Pro Leu Tyr Ile Gly Asn Arg Met Lys Lys Glu Asp Asp Ser 
                565                 570                 575     


Leu Thr Ile Phe Gly Val Ala Glu Arg Asp Gln Gly Ser Tyr Thr Cys 
            580                 585                 590         


Val Ala Ser Thr Glu Leu Asp Gln Asp Leu Ala Lys Ala Tyr Leu Thr 
        595                 600                 605             


Val Leu Ala Asp Gln Ala Thr Pro Thr Asn Arg Leu Ala Ala Leu Pro 
    610                 615                 620                 


Lys Gly Arg Pro Asp Arg Pro Arg Asp Leu Glu Leu Thr Asp Leu Ala 
625                 630                 635                 640 


Glu Arg Ser Val Arg Leu Thr Trp Ile Pro Gly Asp Ala Asn Asn Ser 
                645                 650                 655     


Pro Ile Thr Asp Tyr Val Val Gln Phe Glu Glu Asp Gln Phe Gln Pro 
            660                 665                 670         


Gly Val Trp His Asp His Ser Lys Tyr Pro Gly Ser Val Asn Ser Ala 
        675                 680                 685             


Val Leu Arg Leu Ser Pro Tyr Val Asn Tyr Gln Phe Arg Val Ile Ala 
    690                 695                 700                 


Ile Asn Glu Val Gly Ser Ser His Pro Ser Leu Pro Ser Glu Arg Tyr 
705                 710                 715                 720 


Arg Thr Ser Gly Ala Pro Pro Glu Ser Asn Pro Gly Asp Val Lys Gly 
                725                 730                 735     


Glu Gly Thr Arg Lys Asn Asn Met Glu Ile Thr Trp Thr Pro Met Asn 
            740                 745                 750         


Ala Thr Ser Ala Phe Gly Pro Asn Leu Arg Tyr Ile Val Lys Trp Arg 
        755                 760                 765             


Arg Arg Glu Thr Arg Glu Ala Trp Asn Asn Val Thr Val Trp Gly Ser 
    770                 775                 780                 


Arg Tyr Val Val Gly Gln Thr Pro Val Tyr Val Pro Tyr Glu Ile Arg 
785                 790                 795                 800 


Val Gln Ala Glu Asn Asp Phe Gly Lys Gly Pro Glu Pro Glu Ser Val 
                805                 810                 815     


Ile Gly Tyr Ser Gly Glu Asp Leu Pro Ser Ala Pro Arg Arg Phe Arg 
            820                 825                 830         


Val Arg Gln Pro Asn Leu Glu Thr Ile Asn Leu Glu Trp Asp His Pro 
        835                 840                 845             


Glu His Pro Asn Gly Ile Met Ile Gly Tyr Thr Leu Lys Tyr Val Ala 
    850                 855                 860                 


Phe Asn Gly Thr Lys Val Gly Lys Gln Ile Val Glu Asn Phe Ser Pro 
865                 870                 875                 880 


Asn Gln Thr Lys Phe Thr Val Gln Arg Thr Asp Pro Val Ser Arg Tyr 
                885                 890                 895     


Arg Phe Thr Leu Ser Ala Arg Thr Gln Val Gly Ser Gly Glu Ala Val 
            900                 905                 910         


Thr Glu Glu Ser Pro Ala Pro Pro Asn Glu Ala Thr Pro Thr Ala Ala 
        915                 920                 925             


Pro Pro Thr Leu Pro Pro Thr Thr Val Gly Ala Thr Gly Ala Val Ser 
    930                 935                 940                 


Ser Thr Asp Ala Thr Ala Ile Ala Ala Thr Thr Glu Ala Thr Thr Val 
945                 950                 955                 960 


Pro Ile Ile Pro Thr Val Ala Pro Thr Thr Ile Ala Thr Thr Thr Thr 
                965                 970                 975     


Val Ala Thr Thr Thr Thr Thr Thr Ala Ala Ala Thr Thr Thr Thr Glu 
            980                 985                 990         


Ser Pro Pro Thr Thr Thr Ser Gly  Thr Lys Ile His Glu  Ser Ala Pro 
        995                 1000                 1005             


Asp Glu  Gln Ser Ile Trp Asn  Val Thr Val Leu Pro  Asn Ser Lys 
    1010                 1015                 1020             


Trp Ala  Asn Ile Thr Trp Lys  His Asn Phe Gly Pro  Gly Thr Asp 
    1025                 1030                 1035             


Phe Val  Val Glu Tyr Ile Asp  Ser Asn His Thr Lys  Lys Thr Val 
    1040                 1045                 1050             


Pro Val  Lys Ala Gln Ala Gln  Pro Ile Gln Leu Thr  Asp Leu Tyr 
    1055                 1060                 1065             


Pro Gly  Met Thr Tyr Thr Leu  Arg Val Tyr Ser Arg  Asp Asn Glu 
    1070                 1075                 1080             


Gly Ile  Ser Ser Thr Val Ile  Thr Phe Met Thr Ser  Thr Ala Tyr 
    1085                 1090                 1095             


Thr Asn  Asn Gln Ala Asp Ile  Ala Thr Gln Gly Trp  Phe Ile Gly 
    1100                 1105                 1110             


Leu Met  Cys Ala Ile Ala Leu  Leu Val Leu Ile Leu  Leu Ile Val 
    1115                 1120                 1125             


Cys Phe  Ile Lys Arg Ser Arg  Gly Gly Lys Tyr Pro  Val Arg Glu 
    1130                 1135                 1140             


Lys Lys  Asp Val Pro Leu Gly  Pro Glu Asp Pro Lys  Glu Glu Asp 
    1145                 1150                 1155             


Gly Ser  Phe Asp Tyr Ser Asp  Glu Asp Asn Lys Pro  Leu Gln Gly 
    1160                 1165                 1170             


Ser Gln  Thr Ser Leu Asp Gly  Thr Ile Lys Gln Gln  Glu Ser Asp 
    1175                 1180                 1185             


Asp Ser  Leu Val Asp Tyr Gly  Glu Gly Gly Glu Gly  Gln Phe Asn 
    1190                 1195                 1200             


Glu Asp  Gly Ser Phe Ile Gly  Gln Tyr Thr Val Lys  Lys Asp Lys 
    1205                 1210                 1215             


Glu Glu  Thr Glu Gly Asn Glu  Ser Ser Glu Ala Thr  Ser Pro Val 
    1220                 1225                 1230             


Asn Ala  Ile Tyr Ser Leu Ala  
    1235                 1240 


<210>  9322
<211>  1240
<212>  PRT
<213>  Homo Sapiens

<400>  9322

Met Ala Arg Gln Pro Pro Pro Pro Trp Val His Ala Ala Phe Leu Leu 
1               5                   10                  15      


Cys Leu Leu Ser Leu Gly Gly Ala Ile Glu Ile Pro Met Asp Pro Ser 
            20                  25                  30          


Ile Gln Asn Glu Leu Thr Gln Pro Pro Thr Ile Thr Lys Gln Ser Ala 
        35                  40                  45              


Lys Asp His Ile Val Asp Pro Arg Asp Asn Ile Leu Ile Glu Cys Glu 
    50                  55                  60                  


Ala Lys Gly Asn Pro Ala Pro Ser Phe His Trp Thr Arg Asn Ser Arg 
65                  70                  75                  80  


Phe Phe Asn Ile Ala Lys Asp Pro Arg Val Ser Met Arg Arg Arg Ser 
                85                  90                  95      


Gly Thr Leu Val Ile Asp Phe Arg Ser Gly Gly Arg Pro Glu Glu Tyr 
            100                 105                 110         


Glu Gly Glu Tyr Gln Cys Phe Ala Arg Asn Lys Phe Gly Thr Ala Leu 
        115                 120                 125             


Ser Asn Arg Ile Arg Leu Gln Val Ser Lys Ser Pro Leu Trp Pro Lys 
    130                 135                 140                 


Glu Asn Leu Asp Pro Val Val Val Gln Glu Gly Ala Pro Leu Thr Leu 
145                 150                 155                 160 


Gln Cys Asn Pro Pro Pro Gly Leu Pro Ser Pro Val Ile Phe Trp Met 
                165                 170                 175     


Ser Ser Ser Met Glu Pro Ile Thr Gln Asp Lys Arg Val Ser Gln Gly 
            180                 185                 190         


His Asn Gly Asp Leu Tyr Phe Ser Asn Val Met Leu Gln Asp Met Gln 
        195                 200                 205             


Thr Asp Tyr Ser Cys Asn Ala Arg Phe His Phe Thr His Thr Ile Gln 
    210                 215                 220                 


Gln Lys Asn Pro Phe Thr Leu Lys Val Leu Thr Thr Arg Gly Val Ala 
225                 230                 235                 240 


Glu Arg Thr Pro Ser Phe Met Tyr Pro Gln Gly Thr Ala Ser Ser Gln 
                245                 250                 255     


Met Val Leu Arg Gly Met Asp Leu Leu Leu Glu Cys Ile Ala Ser Gly 
            260                 265                 270         


Val Pro Thr Pro Asp Ile Ala Trp Tyr Lys Lys Gly Gly Asp Leu Pro 
        275                 280                 285             


Ser Asp Lys Ala Lys Phe Glu Asn Phe Asn Lys Ala Leu Arg Ile Thr 
    290                 295                 300                 


Asn Val Ser Glu Glu Asp Ser Gly Glu Tyr Phe Cys Leu Ala Ser Asn 
305                 310                 315                 320 


Lys Met Gly Ser Ile Arg His Thr Ile Ser Val Arg Val Lys Ala Ala 
                325                 330                 335     


Pro Tyr Trp Leu Asp Glu Pro Lys Asn Leu Ile Leu Ala Pro Gly Glu 
            340                 345                 350         


Asp Gly Arg Leu Val Cys Arg Ala Asn Gly Asn Pro Lys Pro Thr Val 
        355                 360                 365             


Gln Trp Met Val Asn Gly Glu Pro Leu Gln Ser Ala Pro Pro Asn Pro 
    370                 375                 380                 


Asn Arg Glu Val Ala Gly Asp Thr Ile Ile Phe Arg Asp Thr Gln Ile 
385                 390                 395                 400 


Ser Ser Arg Ala Val Tyr Gln Cys Asn Thr Ser Asn Glu His Gly Tyr 
                405                 410                 415     


Leu Leu Ala Asn Ala Phe Val Ser Val Leu Asp Val Pro Pro Arg Met 
            420                 425                 430         


Leu Ser Pro Arg Asn Gln Leu Ile Arg Val Ile Leu Tyr Asn Arg Thr 
        435                 440                 445             


Arg Leu Asp Cys Pro Phe Phe Gly Ser Pro Ile Pro Thr Leu Arg Trp 
    450                 455                 460                 


Phe Lys Asn Gly Gln Gly Ser Asn Leu Asp Gly Gly Asn Tyr His Val 
465                 470                 475                 480 


Tyr Glu Asn Gly Ser Leu Glu Ile Lys Met Ile Arg Lys Glu Asp Gln 
                485                 490                 495     


Gly Ile Tyr Thr Cys Val Ala Thr Asn Ile Leu Gly Lys Ala Glu Asn 
            500                 505                 510         


Gln Val Arg Leu Glu Val Lys Asp Pro Thr Arg Ile Tyr Arg Met Pro 
        515                 520                 525             


Glu Asp Gln Val Ala Arg Arg Gly Thr Thr Val Gln Leu Glu Cys Arg 
    530                 535                 540                 


Val Lys His Asp Pro Ser Leu Lys Leu Thr Val Ser Trp Leu Lys Asp 
545                 550                 555                 560 


Asp Glu Pro Leu Tyr Ile Gly Asn Arg Met Lys Lys Glu Asp Asp Ser 
                565                 570                 575     


Leu Thr Ile Phe Gly Val Ala Glu Arg Asp Gln Gly Ser Tyr Thr Cys 
            580                 585                 590         


Val Ala Ser Thr Glu Leu Asp Gln Asp Leu Ala Lys Ala Tyr Leu Thr 
        595                 600                 605             


Val Leu Ala Asp Gln Ala Thr Pro Thr Asn Arg Leu Ala Ala Leu Pro 
    610                 615                 620                 


Lys Gly Arg Pro Asp Arg Pro Arg Asp Leu Glu Leu Thr Asp Leu Ala 
625                 630                 635                 640 


Glu Arg Ser Val Arg Leu Thr Trp Ile Pro Gly Asp Ala Asn Asn Ser 
                645                 650                 655     


Pro Ile Thr Asp Tyr Val Val Gln Phe Glu Glu Asp Gln Phe Gln Pro 
            660                 665                 670         


Gly Val Trp His Asp His Ser Lys Tyr Pro Gly Ser Val Asn Ser Ala 
        675                 680                 685             


Val Leu Arg Leu Ser Pro Tyr Val Asn Tyr Gln Phe Arg Val Ile Ala 
    690                 695                 700                 


Ile Asn Glu Val Gly Ser Ser His Pro Ser Leu Pro Ser Glu Arg Tyr 
705                 710                 715                 720 


Arg Thr Ser Gly Ala Pro Pro Glu Ser Asn Pro Gly Asp Val Lys Gly 
                725                 730                 735     


Glu Gly Thr Arg Lys Asn Asn Met Glu Ile Thr Trp Thr Pro Met Asn 
            740                 745                 750         


Ala Thr Ser Ala Phe Gly Pro Asn Leu Arg Tyr Ile Val Lys Trp Arg 
        755                 760                 765             


Arg Arg Glu Thr Arg Glu Ala Trp Asn Asn Val Thr Val Trp Gly Ser 
    770                 775                 780                 


Arg Tyr Val Val Gly Gln Thr Pro Val Tyr Val Pro Tyr Glu Ile Arg 
785                 790                 795                 800 


Val Gln Ala Glu Asn Asp Phe Gly Lys Gly Pro Glu Pro Glu Ser Val 
                805                 810                 815     


Ile Gly Tyr Ser Gly Glu Asp Leu Pro Ser Ala Pro Arg Arg Phe Arg 
            820                 825                 830         


Val Arg Gln Pro Asn Leu Glu Thr Ile Asn Leu Glu Trp Asp His Pro 
        835                 840                 845             


Glu His Pro Asn Gly Ile Met Ile Gly Tyr Thr Leu Lys Tyr Val Ala 
    850                 855                 860                 


Phe Asn Gly Thr Lys Val Gly Lys Gln Ile Val Glu Asn Phe Ser Pro 
865                 870                 875                 880 


Asn Gln Thr Lys Phe Thr Val Gln Arg Thr Asp Pro Val Ser Arg Tyr 
                885                 890                 895     


Arg Phe Thr Leu Ser Ala Arg Thr Gln Val Gly Ser Gly Glu Ala Val 
            900                 905                 910         


Thr Glu Glu Ser Pro Ala Pro Pro Asn Glu Ala Thr Pro Thr Ala Ala 
        915                 920                 925             


Pro Pro Thr Leu Pro Pro Thr Thr Val Gly Ala Thr Gly Ala Val Ser 
    930                 935                 940                 


Ser Thr Asp Ala Thr Ala Ile Ala Ala Thr Thr Glu Ala Thr Thr Val 
945                 950                 955                 960 


Pro Ile Ile Pro Thr Val Ala Pro Thr Thr Ile Ala Thr Thr Thr Thr 
                965                 970                 975     


Val Ala Thr Thr Thr Thr Thr Thr Ala Ala Ala Thr Thr Thr Thr Glu 
            980                 985                 990         


Ser Pro Pro Thr Thr Thr Ser Gly  Thr Lys Ile His Glu  Ser Ala Pro 
        995                 1000                 1005             


Asp Glu  Gln Ser Ile Trp Asn  Val Thr Val Leu Pro  Asn Ser Lys 
    1010                 1015                 1020             


Trp Ala  Asn Ile Thr Trp Lys  His Asn Phe Gly Pro  Gly Thr Asp 
    1025                 1030                 1035             


Phe Val  Val Glu Tyr Ile Asp  Ser Asn His Thr Lys  Lys Thr Val 
    1040                 1045                 1050             


Pro Val  Lys Ala Gln Ala Gln  Pro Ile Gln Leu Thr  Asp Leu Tyr 
    1055                 1060                 1065             


Pro Gly  Met Thr Tyr Thr Leu  Arg Val Tyr Ser Arg  Asp Asn Glu 
    1070                 1075                 1080             


Gly Ile  Ser Ser Thr Val Ile  Thr Phe Met Thr Ser  Thr Ala Tyr 
    1085                 1090                 1095             


Thr Asn  Asn Gln Ala Asp Ile  Ala Thr Gln Gly Trp  Phe Ile Gly 
    1100                 1105                 1110             


Leu Met  Cys Ala Ile Ala Leu  Leu Val Leu Ile Leu  Leu Ile Val 
    1115                 1120                 1125             


Cys Phe  Ile Lys Arg Ser Arg  Gly Gly Lys Tyr Pro  Val Arg Glu 
    1130                 1135                 1140             


Lys Lys  Asp Val Pro Leu Gly  Pro Glu Asp Pro Lys  Glu Glu Asp 
    1145                 1150                 1155             


Gly Ser  Phe Asp Tyr Ser Asp  Glu Asp Asn Lys Pro  Leu Gln Gly 
    1160                 1165                 1170             


Ser Gln  Thr Ser Leu Asp Gly  Thr Ile Lys Gln Gln  Glu Ser Asp 
    1175                 1180                 1185             


Asp Ser  Leu Val Asp Tyr Gly  Glu Gly Gly Glu Gly  Gln Phe Asn 
    1190                 1195                 1200             


Glu Asp  Gly Ser Phe Ile Gly  Gln Tyr Thr Val Lys  Lys Asp Lys 
    1205                 1210                 1215             


Glu Glu  Thr Glu Gly Asn Glu  Ser Ser Glu Ala Thr  Ser Pro Val 
    1220                 1225                 1230             


Asn Ala  Ile Tyr Ser Leu Ala  
    1235                 1240 


<210>  9323
<211>  619
<212>  PRT
<213>  Homo Sapiens

<400>  9323

Met Ala Arg Gln Pro Pro Pro Pro Trp Val His Ala Ala Phe Leu Leu 
1               5                   10                  15      


Cys Leu Leu Ser Leu Gly Gly Ala Ile Glu Ile Pro Met Asp Pro Ser 
            20                  25                  30          


Ile Gln Asn Glu Leu Thr Gln Pro Pro Thr Ile Thr Lys Gln Ser Ala 
        35                  40                  45              


Lys Asp His Ile Val Asp Pro Arg Asp Asn Ile Leu Ile Glu Cys Glu 
    50                  55                  60                  


Ala Lys Gly Asn Pro Ala Pro Ser Phe His Trp Thr Arg Asn Ser Arg 
65                  70                  75                  80  


Phe Phe Asn Ile Ala Lys Asp Pro Arg Val Ser Met Arg Arg Arg Ser 
                85                  90                  95      


Gly Thr Leu Val Ile Asp Phe Arg Ser Gly Gly Arg Pro Glu Glu Tyr 
            100                 105                 110         


Glu Gly Glu Tyr Gln Cys Phe Ala Arg Asn Lys Phe Gly Thr Ala Leu 
        115                 120                 125             


Ser Asn Arg Ile Arg Leu Gln Val Ser Lys Ser Pro Leu Trp Pro Lys 
    130                 135                 140                 


Glu Asn Leu Asp Pro Val Val Val Gln Glu Gly Ala Pro Leu Thr Leu 
145                 150                 155                 160 


Gln Cys Asn Pro Pro Pro Gly Leu Pro Ser Pro Val Ile Phe Trp Met 
                165                 170                 175     


Ser Ser Ser Met Glu Pro Ile Thr Gln Asp Lys Arg Val Ser Gln Gly 
            180                 185                 190         


His Asn Gly Asp Leu Tyr Phe Ser Asn Val Met Leu Gln Asp Met Gln 
        195                 200                 205             


Thr Asp Tyr Ser Cys Asn Ala Arg Phe His Phe Thr His Thr Ile Gln 
    210                 215                 220                 


Gln Lys Asn Pro Phe Thr Leu Lys Val Leu Thr Thr Arg Gly Val Ala 
225                 230                 235                 240 


Glu Arg Thr Pro Ser Phe Met Tyr Pro Gln Gly Thr Ala Ser Ser Gln 
                245                 250                 255     


Met Val Leu Arg Gly Met Asp Leu Leu Leu Glu Cys Ile Ala Ser Gly 
            260                 265                 270         


Val Pro Thr Pro Asp Ile Ala Trp Tyr Lys Lys Gly Gly Asp Leu Pro 
        275                 280                 285             


Ser Asp Lys Ala Lys Phe Glu Asn Phe Asn Lys Ala Leu Arg Ile Thr 
    290                 295                 300                 


Asn Val Ser Glu Glu Asp Ser Gly Glu Tyr Phe Cys Leu Ala Ser Asn 
305                 310                 315                 320 


Lys Met Gly Ser Ile Arg His Thr Ile Ser Val Arg Val Lys Ala Ala 
                325                 330                 335     


Pro Tyr Trp Leu Asp Glu Pro Lys Asn Leu Ile Leu Ala Pro Gly Glu 
            340                 345                 350         


Asp Gly Arg Leu Val Cys Arg Ala Asn Gly Asn Pro Lys Pro Thr Val 
        355                 360                 365             


Gln Trp Met Val Asn Gly Glu Pro Leu Gln Ser Ala Pro Pro Asn Pro 
    370                 375                 380                 


Asn Arg Glu Val Ala Gly Asp Thr Ile Ile Phe Arg Asp Thr Gln Ile 
385                 390                 395                 400 


Ser Ser Arg Ala Val Tyr Gln Cys Asn Thr Ser Asn Glu His Gly Tyr 
                405                 410                 415     


Leu Leu Ala Asn Ala Phe Val Ser Val Leu Asp Val Pro Pro Arg Met 
            420                 425                 430         


Leu Ser Pro Arg Asn Gln Leu Ile Arg Val Ile Leu Tyr Asn Arg Thr 
        435                 440                 445             


Arg Leu Asp Cys Pro Phe Phe Gly Ser Pro Ile Pro Thr Leu Arg Trp 
    450                 455                 460                 


Phe Lys Asn Gly Gln Gly Ser Asn Leu Asp Gly Gly Asn Tyr His Val 
465                 470                 475                 480 


Tyr Glu Asn Gly Ser Leu Glu Ile Lys Met Ile Arg Lys Glu Asp Gln 
                485                 490                 495     


Gly Ile Tyr Thr Cys Val Ala Thr Asn Ile Leu Gly Lys Ala Glu Asn 
            500                 505                 510         


Gln Val Arg Leu Glu Val Lys Asp Pro Thr Arg Ile Tyr Arg Met Pro 
        515                 520                 525             


Glu Asp Gln Val Ala Arg Arg Gly Thr Thr Val Gln Leu Glu Cys Arg 
    530                 535                 540                 


Val Lys His Asp Pro Ser Leu Lys Leu Thr Val Ser Trp Leu Lys Asp 
545                 550                 555                 560 


Asp Glu Pro Leu Tyr Ile Gly Asn Arg Met Lys Lys Glu Asp Asp Ser 
                565                 570                 575     


Leu Thr Ile Phe Gly Val Ala Glu Arg Asp Gln Gly Ser Tyr Thr Cys 
            580                 585                 590         


Val Ala Ser Thr Glu Leu Asp Gln Asp Leu Ala Lys Ala Tyr Leu Thr 
        595                 600                 605             


Val Leu Gly Asn Cys Pro Cys Ser Pro Trp His 
    610                 615                 


<210>  9324
<211>  218
<212>  PRT
<213>  Homo Sapiens

<400>  9324

Pro Pro Thr Thr Val Gly Ala Thr Gly Ala Val Ser Ser Thr Asp Ala 
1               5                   10                  15      


Thr Ala Ile Ala Ala Thr Thr Glu Ala Thr Thr Val Pro Ile Ile Pro 
            20                  25                  30          


Thr Val Ala Pro Thr Thr Ile Ala Thr Thr Thr Thr Val Ala Thr Thr 
        35                  40                  45              


Thr Thr Thr Thr Ala Ala Ala Thr Thr Thr Thr Glu Ser Pro Pro Thr 
    50                  55                  60                  


Thr Thr Ser Gly Thr Lys Ile His Glu Ser Ala Tyr Thr Asn Asn Gln 
65                  70                  75                  80  


Ala Asp Ile Ala Thr Gln Gly Trp Phe Ile Gly Leu Met Cys Ala Ile 
                85                  90                  95      


Ala Leu Leu Val Leu Ile Leu Leu Ile Val Cys Phe Ile Lys Arg Ser 
            100                 105                 110         


Arg Gly Gly Lys Tyr Pro Val Arg Glu Lys Lys Asp Val Pro Leu Gly 
        115                 120                 125             


Pro Glu Asp Pro Lys Glu Glu Asp Gly Ser Phe Asp Tyr Ser Asp Glu 
    130                 135                 140                 


Asp Asn Lys Pro Leu Gln Gly Ser Gln Thr Ser Leu Asp Gly Thr Ile 
145                 150                 155                 160 


Lys Gln Gln Glu Ser Asp Asp Ser Leu Val Asp Tyr Gly Glu Gly Gly 
                165                 170                 175     


Glu Gly Gln Phe Asn Glu Asp Gly Ser Phe Ile Gly Gln Tyr Thr Val 
            180                 185                 190         


Lys Lys Asp Lys Glu Glu Thr Glu Gly Asn Glu Ser Ser Glu Ala Thr 
        195                 200                 205             


Ser Pro Val Asn Ala Ile Tyr Ser Leu Ala 
    210                 215             


<210>  9325
<211>  237
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9325

Xaa Glu Asn Phe Ser Pro Asn Gln Thr Lys Phe Thr Val Gln Arg Thr 
1               5                   10                  15      


Asp Pro Val Ser Arg Tyr Arg Phe Thr Leu Ser Ala Arg Thr Gln Val 
            20                  25                  30          


Gly Ser Gly Glu Ala Val Thr Glu Glu Ser Pro Ala Pro Pro Asn Glu 
        35                  40                  45              


Ala Thr Pro Thr Ala Ala Pro Asp Glu Gln Ser Ile Trp Asn Val Thr 
    50                  55                  60                  


Val Leu Pro Asn Ser Lys Trp Ala Asn Ile Thr Trp Lys His Asn Phe 
65                  70                  75                  80  


Gly Pro Gly Thr Asp Phe Val Val Glu Tyr Ile Asp Ser Asn His Thr 
                85                  90                  95      


Lys Lys Thr Val Pro Val Lys Ala Gln Ala Gln Pro Ile Gln Leu Thr 
            100                 105                 110         


Asp Leu Tyr Pro Gly Met Thr Tyr Thr Leu Arg Val Tyr Ser Arg Asp 
        115                 120                 125             


Asn Glu Gly Ile Ser Ser Thr Val Ile Thr Phe Met Thr Ser Thr Ala 
    130                 135                 140                 


Tyr Thr Asn Asn Gln Ala Asp Ile Ala Thr Gln Gly Trp Phe Ile Gly 
145                 150                 155                 160 


Leu Met Cys Ala Ile Ala Leu Leu Val Leu Ile Leu Leu Ile Val Cys 
                165                 170                 175     


Phe Ile Lys Arg Ser Arg Gly Gly Lys Tyr Pro Val Arg Glu Lys Lys 
            180                 185                 190         


Asp Val Pro Leu Gly Pro Glu Asp Pro Lys Glu Glu Asp Gly Ser Phe 
        195                 200                 205             


Asp Tyr Ser Asp Glu Asp Asn Lys Pro Leu Gln Gly Ser Gln Thr Ser 
    210                 215                 220                 


Leu Asp Gly Thr Ile Lys Gln Gln Glu Ser Asp Asp Ser 
225                 230                 235         


<210>  9326
<211>  298
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9326

Xaa Arg Glu Thr Arg Glu Ala Trp Asn Asn Val Thr Val Trp Gly Ser 
1               5                   10                  15      


Arg Tyr Val Val Gly Gln Thr Pro Val Tyr Val Pro Tyr Glu Ile Arg 
            20                  25                  30          


Val Gln Ala Glu Asn Asp Phe Gly Lys Gly Pro Glu Pro Glu Ser Val 
        35                  40                  45              


Ile Gly Tyr Ser Gly Glu Asp Leu Pro Ser Ala Pro Arg Arg Phe Arg 
    50                  55                  60                  


Val Arg Gln Pro Asn Leu Glu Thr Ile Asn Leu Glu Trp Asp His Pro 
65                  70                  75                  80  


Glu His Pro Asn Gly Ile Met Ile Gly Tyr Thr Leu Lys Tyr Val Ala 
                85                  90                  95      


Phe Asn Gly Thr Lys Val Gly Lys Gln Ile Val Glu Asn Phe Ser Pro 
            100                 105                 110         


Asn Gln Thr Lys Phe Thr Val Gln Arg Thr Asp Pro Val Ser Arg Tyr 
        115                 120                 125             


Arg Phe Thr Leu Ser Ala Arg Thr Gln Val Gly Ser Gly Glu Ala Val 
    130                 135                 140                 


Thr Glu Glu Ser Pro Ala Pro Pro Asn Glu Ala Tyr Thr Asn Asn Gln 
145                 150                 155                 160 


Ala Asp Ile Ala Thr Gln Gly Trp Phe Ile Gly Leu Met Cys Ala Ile 
                165                 170                 175     


Ala Leu Leu Val Leu Ile Leu Leu Ile Val Cys Phe Ile Lys Arg Ser 
            180                 185                 190         


Arg Gly Gly Lys Tyr Pro Val Arg Glu Lys Lys Asp Val Pro Leu Gly 
        195                 200                 205             


Pro Glu Asp Pro Lys Glu Glu Asp Gly Ser Phe Asp Tyr Ser Asp Glu 
    210                 215                 220                 


Asp Asn Lys Pro Leu Gln Gly Ser Gln Thr Ser Leu Asp Gly Thr Ile 
225                 230                 235                 240 


Lys Gln Gln Glu Ser Asp Asp Ser Leu Val Asp Tyr Gly Glu Gly Gly 
                245                 250                 255     


Glu Gly Gln Phe Asn Glu Asp Gly Ser Phe Ile Gly Gln Tyr Thr Val 
            260                 265                 270         


Lys Lys Asp Lys Glu Glu Thr Glu Gly Asn Glu Ser Ser Glu Ala Thr 
        275                 280                 285             


Ser Pro Val Asn Ala Ile Tyr Ser Leu Ala 
    290                 295             


<210>  9327
<211>  1041
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9327

Xaa Ser Ile Gln Asn Glu Leu Thr Gln Pro Pro Thr Ile Thr Lys Gln 
1               5                   10                  15      


Ser Ala Lys Asp His Ile Val Asp Pro Arg Asp Asn Ile Leu Ile Glu 
            20                  25                  30          


Cys Glu Ala Lys Gly Asn Pro Ala Pro Ser Phe His Trp Thr Arg Asn 
        35                  40                  45              


Ser Arg Phe Phe Asn Ile Ala Lys Asp Pro Arg Val Ser Met Arg Arg 
    50                  55                  60                  


Arg Ser Gly Thr Leu Val Ile Asp Phe Arg Ser Gly Gly Arg Pro Glu 
65                  70                  75                  80  


Glu Tyr Glu Gly Glu Tyr Gln Cys Phe Ala Arg Asn Lys Phe Gly Thr 
                85                  90                  95      


Ala Leu Ser Asn Arg Ile Arg Leu Gln Val Ser Lys Ser Pro Leu Trp 
            100                 105                 110         


Pro Lys Glu Asn Leu Asp Pro Val Val Val Gln Glu Gly Ala Pro Leu 
        115                 120                 125             


Thr Leu Gln Cys Asn Pro Pro Pro Gly Leu Pro Ser Pro Val Ile Phe 
    130                 135                 140                 


Trp Met Ser Ser Ser Met Glu Pro Ile Thr Gln Asp Lys Arg Val Ser 
145                 150                 155                 160 


Gln Gly His Asn Gly Asp Leu Tyr Phe Ser Asn Val Met Leu Gln Asp 
                165                 170                 175     


Met Gln Thr Asp Tyr Ser Cys Asn Ala Arg Phe His Phe Thr His Thr 
            180                 185                 190         


Ile Gln Gln Lys Asn Pro Phe Thr Leu Lys Val Leu Thr Thr Arg Gly 
        195                 200                 205             


Val Ala Glu Arg Thr Pro Ser Phe Met Tyr Pro Gln Gly Thr Ala Ser 
    210                 215                 220                 


Ser Gln Met Val Leu Arg Gly Met Asp Leu Leu Leu Glu Cys Ile Ala 
225                 230                 235                 240 


Ser Gly Val Pro Thr Pro Asp Ile Ala Trp Tyr Lys Lys Gly Gly Asp 
                245                 250                 255     


Leu Pro Ser Asp Lys Ala Lys Phe Glu Asn Phe Asn Lys Ala Leu Arg 
            260                 265                 270         


Ile Thr Asn Val Ser Glu Glu Asp Ser Gly Glu Tyr Phe Cys Leu Ala 
        275                 280                 285             


Ser Asn Lys Met Gly Ser Ile Arg His Thr Ile Ser Val Arg Val Lys 
    290                 295                 300                 


Ala Ala Pro Tyr Trp Leu Asp Glu Pro Lys Asn Leu Ile Leu Ala Pro 
305                 310                 315                 320 


Gly Glu Asp Gly Arg Leu Val Cys Arg Ala Asn Gly Asn Pro Lys Pro 
                325                 330                 335     


Thr Val Gln Trp Met Val Asn Gly Glu Pro Leu Gln Ser Ala Pro Pro 
            340                 345                 350         


Asn Pro Asn Arg Glu Val Ala Gly Asp Thr Ile Ile Phe Arg Asp Thr 
        355                 360                 365             


Gln Ile Ser Ser Arg Ala Val Tyr Gln Cys Asn Thr Ser Asn Glu His 
    370                 375                 380                 


Gly Tyr Leu Leu Ala Asn Ala Phe Val Ser Val Leu Asp Val Pro Pro 
385                 390                 395                 400 


Arg Met Leu Ser Pro Arg Asn Gln Leu Ile Arg Val Ile Leu Tyr Asn 
                405                 410                 415     


Arg Thr Arg Leu Asp Cys Pro Phe Phe Gly Ser Pro Ile Pro Thr Leu 
            420                 425                 430         


Arg Trp Phe Lys Asn Gly Gln Gly Ser Asn Leu Asp Gly Gly Asn Tyr 
        435                 440                 445             


His Val Tyr Glu Asn Gly Ser Leu Glu Ile Lys Met Ile Arg Lys Glu 
    450                 455                 460                 


Asp Gln Gly Ile Tyr Thr Cys Val Ala Thr Asn Ile Leu Gly Lys Ala 
465                 470                 475                 480 


Glu Asn Gln Val Arg Leu Glu Val Lys Asp Pro Thr Arg Ile Tyr Arg 
                485                 490                 495     


Met Pro Glu Asp Gln Val Ala Arg Arg Gly Thr Thr Val Gln Leu Glu 
            500                 505                 510         


Cys Arg Val Lys His Asp Pro Ser Leu Lys Leu Thr Val Ser Trp Leu 
        515                 520                 525             


Lys Asp Asp Glu Pro Leu Tyr Ile Gly Asn Arg Met Lys Lys Glu Asp 
    530                 535                 540                 


Asp Ser Leu Thr Ile Phe Gly Val Ala Glu Arg Asp Gln Gly Ser Tyr 
545                 550                 555                 560 


Thr Cys Val Ala Ser Thr Glu Leu Asp Gln Asp Leu Ala Lys Ala Tyr 
                565                 570                 575     


Leu Thr Val Leu Ala Asp Gln Ala Thr Pro Thr Asn Arg Leu Ala Ala 
            580                 585                 590         


Leu Pro Lys Gly Arg Pro Asp Arg Pro Arg Asp Leu Glu Leu Thr Asp 
        595                 600                 605             


Leu Ala Glu Arg Ser Val Arg Leu Thr Trp Ile Pro Gly Asp Ala Asn 
    610                 615                 620                 


Asn Ser Pro Ile Thr Asp Tyr Val Val Gln Phe Glu Glu Asp Gln Phe 
625                 630                 635                 640 


Gln Pro Gly Val Trp His Asp His Ser Lys Tyr Pro Gly Ser Val Asn 
                645                 650                 655     


Ser Ala Val Leu Arg Leu Ser Pro Tyr Val Asn Tyr Gln Phe Arg Val 
            660                 665                 670         


Ile Ala Ile Asn Glu Val Gly Ser Ser His Pro Ser Leu Pro Ser Glu 
        675                 680                 685             


Arg Tyr Arg Thr Ser Gly Ala Pro Pro Glu Ser Asn Pro Gly Asp Val 
    690                 695                 700                 


Lys Gly Glu Gly Thr Arg Lys Asn Asn Met Glu Ile Thr Trp Thr Pro 
705                 710                 715                 720 


Met Asn Ala Thr Ser Ala Phe Gly Pro Asn Leu Arg Tyr Ile Val Lys 
                725                 730                 735     


Trp Arg Arg Arg Glu Thr Arg Glu Ala Trp Asn Asn Val Thr Val Trp 
            740                 745                 750         


Gly Ser Arg Tyr Val Val Gly Gln Thr Pro Val Tyr Val Pro Tyr Glu 
        755                 760                 765             


Ile Arg Val Gln Ala Glu Asn Asp Phe Gly Lys Gly Pro Glu Pro Glu 
    770                 775                 780                 


Ser Val Ile Gly Tyr Ser Gly Glu Asp Leu Pro Ser Ala Pro Arg Arg 
785                 790                 795                 800 


Phe Arg Val Arg Gln Pro Asn Leu Glu Thr Ile Asn Leu Glu Trp Asp 
                805                 810                 815     


His Pro Glu His Pro Asn Gly Ile Met Ile Gly Tyr Thr Leu Lys Tyr 
            820                 825                 830         


Val Ala Phe Asn Gly Thr Lys Val Gly Lys Gln Ile Val Glu Asn Phe 
        835                 840                 845             


Ser Pro Asn Gln Thr Lys Phe Thr Val Gln Arg Thr Asp Pro Val Ser 
    850                 855                 860                 


Arg Tyr Arg Phe Thr Leu Ser Ala Arg Thr Gln Val Gly Ser Gly Glu 
865                 870                 875                 880 


Ala Val Thr Glu Glu Ser Pro Ala Pro Pro Asn Glu Ala Thr Pro Thr 
                885                 890                 895     


Ala Ala Tyr Thr Asn Asn Gln Ala Asp Ile Ala Thr Gln Gly Trp Phe 
            900                 905                 910         


Ile Gly Leu Met Cys Ala Ile Ala Leu Leu Val Leu Ile Leu Leu Ile 
        915                 920                 925             


Val Cys Phe Ile Lys Arg Ser Arg Gly Gly Lys Tyr Pro Val Arg Glu 
    930                 935                 940                 


Lys Lys Asp Val Pro Leu Gly Pro Glu Asp Pro Lys Glu Glu Asp Gly 
945                 950                 955                 960 


Ser Phe Asp Tyr Ser Asp Glu Asp Asn Lys Pro Leu Gln Gly Ser Gln 
                965                 970                 975     


Thr Ser Leu Asp Gly Thr Ile Lys Gln Gln Glu Ser Asp Asp Ser Leu 
            980                 985                 990         


Val Asp Tyr Gly Glu Gly Gly Glu  Gly Gln Phe Asn Glu  Asp Gly Ser 
        995                 1000                 1005             


Phe Ile  Gly Gln Tyr Thr Val  Lys Lys Asp Lys Glu  Glu Thr Glu 
    1010                 1015                 1020             


Gly Asn  Glu Ser Ser Glu Ala  Thr Ser Pro Val Asn  Ala Ile Tyr 
    1025                 1030                 1035             


Ser Leu  Ala 
    1040     


<210>  9328
<211>  573
<212>  PRT
<213>  Homo Sapiens

<400>  9328

Met Gly Trp Glu Ser His Leu Thr Ala Ala Ser Ala Asp Ile Asp Leu 
1               5                   10                  15      


Gly Ala Gly Arg Glu Val Phe Asp Tyr Ser His Arg Gln Lys Glu Gln 
            20                  25                  30          


Asp Val Glu Lys Glu Leu Arg Asp Gly Gly Glu Gln Asp Thr Trp Ala 
        35                  40                  45              


Gly Glu Gly Ala Glu Ala Leu Ala Arg Asn Leu Leu Val Asp Gly Glu 
    50                  55                  60                  


Thr Gly Glu Ser Phe Pro Ala Gln Phe Pro Ala Asp Ile Ser Ser Ile 
65                  70                  75                  80  


Thr Glu Ala Val Pro Ser Glu Ser Glu Pro Pro Ala Leu Gln Asn Asn 
                85                  90                  95      


Leu Leu Ser Pro Leu Leu Thr Gly Thr Glu Ser Pro Phe Asp Leu Glu 
            100                 105                 110         


Gln Gln Trp Gln Asp Leu Met Ser Ile Met Glu Met Gln Ala Met Glu 
        115                 120                 125             


Val Asn Thr Ser Ala Ser Glu Ile Leu Tyr Ser Ala Pro Pro Gly Asp 
    130                 135                 140                 


Pro Leu Ser Thr Asn Tyr Ser Leu Ala Pro Asn Thr Pro Ile Asn Gln 
145                 150                 155                 160 


Asn Val Ser Leu His Gln Ala Ser Leu Gly Gly Cys Ser Gln Asp Phe 
                165                 170                 175     


Leu Leu Phe Ser Pro Glu Val Glu Ser Leu Pro Val Ala Ser Ser Ser 
            180                 185                 190         


Thr Leu Leu Pro Leu Ala Pro Ser Asn Ser Thr Ser Leu Asn Ser Thr 
        195                 200                 205             


Phe Gly Ser Thr Asn Leu Thr Gly Leu Phe Phe Pro Pro Gln Leu Asn 
    210                 215                 220                 


Gly Thr Ala Asn Asp Thr Ala Gly Pro Glu Leu Pro Asp Pro Leu Gly 
225                 230                 235                 240 


Gly Leu Leu Asp Glu Ala Met Leu Asp Glu Ile Ser Leu Met Asp Leu 
                245                 250                 255     


Ala Ile Glu Glu Gly Phe Asn Pro Val Gln Ala Ser Gln Leu Glu Glu 
            260                 265                 270         


Glu Phe Asp Ser Asp Ser Gly Leu Ser Leu Asp Ser Ser His Ser Pro 
        275                 280                 285             


Ser Ser Leu Ser Ser Ser Glu Gly Ser Ser Ser Ser Ser Ser Ser Ser 
    290                 295                 300                 


Ser Ser Ser Ser Ser Ser Ala Ser Ser Ser Ala Ser Ser Ser Phe Ser 
305                 310                 315                 320 


Glu Glu Gly Ala Val Gly Tyr Ser Ser Asp Ser Glu Thr Leu Asp Leu 
                325                 330                 335     


Glu Glu Ala Glu Gly Ala Val Gly Tyr Gln Pro Glu Tyr Ser Lys Phe 
            340                 345                 350         


Cys Arg Met Ser Tyr Gln Asp Pro Ala Gln Leu Ser Cys Leu Pro Tyr 
        355                 360                 365             


Leu Glu His Val Gly His Asn His Thr Tyr Asn Met Ala Pro Ser Ala 
    370                 375                 380                 


Leu Asp Ser Ala Asp Leu Pro Pro Pro Ser Ala Leu Lys Lys Gly Ser 
385                 390                 395                 400 


Lys Glu Lys Gln Ala Asp Phe Leu Asp Lys Gln Met Ser Arg Asp Glu 
                405                 410                 415     


His Arg Ala Arg Ala Met Lys Ile Pro Phe Thr Asn Asp Lys Ile Ile 
            420                 425                 430         


Asn Leu Pro Val Glu Glu Phe Asn Glu Leu Leu Ser Lys Tyr Gln Leu 
        435                 440                 445             


Ser Glu Ala Gln Leu Ser Leu Ile Arg Asp Ile Arg Arg Arg Gly Lys 
    450                 455                 460                 


Asn Lys Met Ala Ala Gln Asn Cys Arg Lys Arg Lys Leu Asp Thr Ile 
465                 470                 475                 480 


Leu Asn Leu Glu Arg Asp Val Glu Asp Leu Gln Arg Asp Lys Ala Arg 
                485                 490                 495     


Leu Leu Arg Glu Lys Val Glu Phe Leu Arg Ser Leu Arg Gln Met Lys 
            500                 505                 510         


Gln Lys Val Gln Ser Leu Tyr Gln Glu Val Phe Gly Arg Leu Arg Asp 
        515                 520                 525             


Glu Asn Gly Arg Pro Tyr Ser Pro Ser Gln Tyr Ala Leu Gln Tyr Ala 
    530                 535                 540                 


Gly Asp Gly Ser Val Leu Leu Ile Pro Arg Thr Met Ala Asp Gln Gln 
545                 550                 555                 560 


Ala Arg Arg Gln Glu Arg Lys Pro Lys Asp Arg Arg Lys 
                565                 570             


<210>  9329
<211>  584
<212>  PRT
<213>  Homo Sapiens

<400>  9329

Met Gly Trp Glu Ser His Leu Thr Ala Ala Ser Ala Asp Ile Asp Leu 
1               5                   10                  15      


Ile Asp Ile Leu Trp Arg Gln Asp Ile Asp Leu Gly Ala Gly Arg Glu 
            20                  25                  30          


Val Phe Asp Tyr Ser His Arg Gln Lys Glu Gln Asp Val Glu Lys Glu 
        35                  40                  45              


Leu Arg Asp Gly Gly Glu Gln Asp Thr Trp Ala Gly Glu Gly Ala Glu 
    50                  55                  60                  


Ala Leu Ala Arg Asn Leu Leu Val Asp Gly Glu Thr Gly Glu Ser Phe 
65                  70                  75                  80  


Pro Ala Gln Phe Pro Ala Asp Ile Ser Ser Ile Thr Glu Ala Val Pro 
                85                  90                  95      


Ser Glu Ser Glu Pro Pro Ala Leu Gln Asn Asn Leu Leu Ser Pro Leu 
            100                 105                 110         


Leu Thr Gly Thr Glu Ser Pro Phe Asp Leu Glu Gln Gln Trp Gln Asp 
        115                 120                 125             


Leu Met Ser Ile Met Glu Met Gln Ala Met Glu Val Asn Thr Ser Ala 
    130                 135                 140                 


Ser Glu Ile Leu Tyr Ser Ala Pro Pro Gly Asp Pro Leu Ser Thr Asn 
145                 150                 155                 160 


Tyr Ser Leu Ala Pro Asn Thr Pro Ile Asn Gln Asn Val Ser Leu His 
                165                 170                 175     


Gln Ala Ser Leu Gly Gly Cys Ser Gln Asp Phe Leu Leu Phe Ser Pro 
            180                 185                 190         


Glu Val Glu Ser Leu Pro Val Ala Ser Ser Ser Thr Leu Leu Pro Leu 
        195                 200                 205             


Ala Pro Ser Asn Ser Thr Ser Leu Asn Ser Thr Phe Gly Ser Thr Asn 
    210                 215                 220                 


Leu Thr Gly Leu Phe Phe Pro Pro Gln Leu Asn Gly Thr Ala Asn Asp 
225                 230                 235                 240 


Thr Ala Gly Pro Glu Leu Pro Asp Pro Leu Gly Gly Leu Leu Asp Glu 
                245                 250                 255     


Ala Met Leu Asp Glu Ile Ser Leu Met Asp Leu Ala Ile Glu Glu Gly 
            260                 265                 270         


Phe Asn Pro Val Gln Ala Ser Gln Leu Glu Glu Glu Phe Asp Ser Asp 
        275                 280                 285             


Ser Gly Leu Ser Leu Asp Ser Ser His Ser Pro Ser Ser Leu Ser Ser 
    290                 295                 300                 


Ser Glu Gly Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
305                 310                 315                 320 


Ser Ala Ser Ser Ser Ala Ser Ser Ser Phe Ser Glu Glu Gly Ala Val 
                325                 330                 335     


Gly Tyr Ser Ser Asp Ser Glu Thr Leu Asp Leu Glu Glu Ala Glu Gly 
            340                 345                 350         


Ala Val Gly Tyr Gln Pro Glu Tyr Ser Lys Phe Cys Arg Met Ser Tyr 
        355                 360                 365             


Gln Asp Pro Ala Gln Leu Ser Cys Leu Pro Tyr Leu Glu His Val Gly 
    370                 375                 380                 


His Asn His Thr Tyr Asn Met Ala Pro Ser Ala Leu Asp Ser Ala Asp 
385                 390                 395                 400 


Leu Pro Pro Pro Ser Ala Leu Lys Lys Gly Ser Lys Glu Lys Gln Ala 
                405                 410                 415     


Asp Phe Leu Asp Lys Gln Met Ser Arg Asp Glu His Arg Ala Arg Ala 
            420                 425                 430         


Met Lys Ile Pro Phe Thr Asn Asp Lys Ile Ile Asn Leu Pro Val Glu 
        435                 440                 445             


Glu Phe Asn Glu Leu Leu Ser Lys Tyr Gln Leu Ser Glu Ala Gln Leu 
    450                 455                 460                 


Ser Leu Ile Arg Asp Ile Arg Arg Arg Gly Lys Asn Lys Met Ala Ala 
465                 470                 475                 480 


Gln Asn Cys Arg Lys Arg Lys Leu Asp Thr Ile Leu Asn Leu Glu Arg 
                485                 490                 495     


Asp Val Glu Asp Leu Gln Arg Asp Lys Ala Arg Leu Leu Arg Glu Lys 
            500                 505                 510         


Val Glu Phe Leu Arg Ser Leu Arg Gln Met Lys Gln Lys Val Gln Ser 
        515                 520                 525             


Leu Tyr Gln Glu Val Phe Gly Arg Leu Arg Asp Glu Asn Gly Arg Pro 
    530                 535                 540                 


Tyr Ser Pro Ser Gln Tyr Ala Leu Gln Tyr Ala Gly Asp Gly Ser Val 
545                 550                 555                 560 


Leu Leu Ile Pro Arg Thr Met Ala Asp Gln Gln Ala Arg Arg Gln Glu 
                565                 570                 575     


Arg Lys Pro Lys Asp Arg Arg Lys 
            580                 


<210>  9330
<211>  4
<212>  PRT
<213>  Homo Sapiens

<400>  9330

Met Leu Ser Leu 
1               


<210>  9331
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  9331

Met Leu Ser Leu Lys Lys Tyr Leu Thr 
1               5                   


<210>  9332
<211>  83
<212>  PRT
<213>  Homo Sapiens

<400>  9332

Met Leu Ser Leu Lys Lys Tyr Leu Thr Glu Gly Leu Leu Gln Phe Thr 
1               5                   10                  15      


Ile Leu Leu Ser Leu Ile Gly Val Arg Val Asp Val Asp Thr Tyr Leu 
            20                  25                  30          


Thr Ser Gln Leu Pro Pro Leu Arg Glu Ile Ile Leu Gly Pro Ser Ser 
        35                  40                  45              


Ala Tyr Thr Gln Thr Gln Phe His Asn Leu Arg Asn Thr Leu Asp Gly 
    50                  55                  60                  


Tyr Gly Ile His Pro Lys Ser Ile Asp Leu Asp Asn Tyr Phe Thr Ala 
65                  70                  75                  80  


Arg Arg Leu 
            


<210>  9333
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  9333

Met Leu Ser Leu Lys Lys Tyr Leu Thr Glu Gly Leu Leu Gln Phe Thr 
1               5                   10                  15      


Ile Leu Leu Ser Leu Ile Gly Val Arg Val Asp Val Asp Thr Tyr Leu 
            20                  25                  30          


Thr Ser Gln Leu Pro Pro Leu Arg Glu Ile Ile Leu Gly Pro Ser Ser 
        35                  40                  45              


Ala Tyr Thr Gln Thr Gln Phe His Asn Leu Arg Asn Thr Leu Asp Gly 
    50                  55                  60                  


Tyr Gly Ile His Pro Lys Ser Ile Asp Leu Asp Asn Tyr Phe Thr Ala 
65                  70                  75                  80  


Arg Arg Leu Leu Ser Gln Val Arg Ala Leu Asp Arg Phe Gln Val Pro 
                85                  90                  95      


Thr Thr Glu 
            


<210>  9334
<211>  761
<212>  PRT
<213>  Homo Sapiens

<400>  9334

Met Leu Ser Leu Lys Lys Tyr Leu Thr Glu Gly Leu Leu Gln Phe Thr 
1               5                   10                  15      


Ile Leu Leu Ser Leu Ile Gly Val Arg Val Asp Val Asp Thr Tyr Leu 
            20                  25                  30          


Thr Ser Gln Leu Pro Pro Leu Arg Glu Ile Ile Leu Gly Pro Ser Ser 
        35                  40                  45              


Ala Tyr Thr Gln Thr Gln Phe His Asn Leu Arg Asn Thr Leu Asp Gly 
    50                  55                  60                  


Tyr Gly Ile His Pro Lys Ser Ile Asp Leu Asp Asn Tyr Phe Thr Ala 
65                  70                  75                  80  


Arg Arg Leu Leu Ser Gln Val Arg Ala Leu Asp Arg Phe Gln Val Pro 
                85                  90                  95      


Thr Thr Glu Val Asn Ala Trp Leu Val His Arg Asp Pro Glu Gly Ser 
            100                 105                 110         


Val Ser Gly Ser Gln Pro Asn Ser Gly Leu Ala Leu Glu Ser Ser Ser 
        115                 120                 125             


Gly Leu Gln Asp Val Thr Gly Pro Asp Asn Gly Val Arg Glu Ser Glu 
    130                 135                 140                 


Thr Glu Gln Gly Phe Gly Glu Asp Leu Glu Asp Leu Gly Ala Val Ala 
145                 150                 155                 160 


Pro Pro Val Ser Gly Asp Leu Thr Lys Glu Asp Ile Asp Leu Gly Ala 
                165                 170                 175     


Gly Arg Glu Val Phe Asp Tyr Ser His Arg Gln Lys Glu Gln Asp Val 
            180                 185                 190         


Glu Lys Glu Leu Arg Asp Gly Gly Glu Gln Asp Thr Trp Ala Gly Glu 
        195                 200                 205             


Gly Ala Glu Ala Leu Ala Arg Asn Leu Leu Val Asp Gly Glu Thr Gly 
    210                 215                 220                 


Glu Ser Phe Pro Ala Gln Val Pro Ser Gly Glu Asp Gln Thr Ala Leu 
225                 230                 235                 240 


Ser Leu Glu Glu Cys Leu Arg Leu Leu Glu Ala Thr Cys Pro Phe Gly 
                245                 250                 255     


Glu Asn Ala Glu Phe Pro Ala Asp Ile Ser Ser Ile Thr Glu Ala Val 
            260                 265                 270         


Pro Ser Glu Ser Glu Pro Pro Ala Leu Gln Asn Asn Leu Leu Ser Pro 
        275                 280                 285             


Leu Leu Thr Gly Thr Glu Ser Pro Phe Asp Leu Glu Gln Gln Trp Gln 
    290                 295                 300                 


Asp Leu Met Ser Ile Met Glu Met Gln Ala Met Glu Val Asn Thr Ser 
305                 310                 315                 320 


Ala Ser Glu Ile Leu Tyr Ser Ala Pro Pro Gly Asp Pro Leu Ser Thr 
                325                 330                 335     


Asn Tyr Ser Leu Ala Pro Asn Thr Pro Ile Asn Gln Asn Val Ser Leu 
            340                 345                 350         


His Gln Ala Ser Leu Gly Gly Cys Ser Gln Asp Phe Leu Leu Phe Ser 
        355                 360                 365             


Pro Glu Val Glu Ser Leu Pro Val Ala Ser Ser Ser Thr Leu Leu Pro 
    370                 375                 380                 


Leu Ala Pro Ser Asn Ser Thr Ser Leu Asn Ser Thr Phe Gly Ser Thr 
385                 390                 395                 400 


Asn Leu Thr Gly Leu Phe Phe Pro Pro Gln Leu Asn Gly Thr Ala Asn 
                405                 410                 415     


Asp Thr Ala Gly Pro Glu Leu Pro Asp Pro Leu Gly Gly Leu Leu Asp 
            420                 425                 430         


Glu Ala Met Leu Asp Glu Ile Ser Leu Met Asp Leu Ala Ile Glu Glu 
        435                 440                 445             


Gly Phe Asn Pro Val Gln Ala Ser Gln Leu Glu Glu Glu Phe Asp Ser 
    450                 455                 460                 


Asp Ser Gly Leu Ser Leu Asp Ser Ser His Ser Pro Ser Ser Leu Ser 
465                 470                 475                 480 


Ser Ser Glu Gly Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
                485                 490                 495     


Ser Ser Ala Ser Ser Ser Ala Ser Ser Ser Phe Ser Glu Glu Gly Ala 
            500                 505                 510         


Val Gly Tyr Ser Ser Asp Ser Glu Thr Leu Asp Leu Glu Glu Ala Glu 
        515                 520                 525             


Gly Ala Val Gly Tyr Gln Pro Glu Tyr Ser Lys Phe Cys Arg Met Ser 
    530                 535                 540                 


Tyr Gln Asp Pro Ala Gln Leu Ser Cys Leu Pro Tyr Leu Glu His Val 
545                 550                 555                 560 


Gly His Asn His Thr Tyr Asn Met Ala Pro Ser Ala Leu Asp Ser Ala 
                565                 570                 575     


Asp Leu Pro Pro Pro Ser Ala Leu Lys Lys Gly Ser Lys Glu Lys Gln 
            580                 585                 590         


Ala Asp Phe Leu Asp Lys Gln Met Ser Arg Asp Glu His Arg Ala Arg 
        595                 600                 605             


Ala Met Lys Ile Pro Phe Thr Asn Asp Lys Ile Ile Asn Leu Pro Val 
    610                 615                 620                 


Glu Glu Phe Asn Glu Leu Leu Ser Lys Tyr Gln Leu Ser Glu Ala Gln 
625                 630                 635                 640 


Leu Ser Leu Ile Arg Asp Ile Arg Arg Arg Gly Lys Asn Lys Met Ala 
                645                 650                 655     


Ala Gln Asn Cys Arg Lys Arg Lys Leu Asp Thr Ile Leu Asn Leu Glu 
            660                 665                 670         


Arg Asp Val Glu Asp Leu Gln Arg Asp Lys Ala Arg Leu Leu Arg Glu 
        675                 680                 685             


Lys Val Glu Phe Leu Arg Ser Leu Arg Gln Met Lys Gln Lys Val Gln 
    690                 695                 700                 


Ser Leu Tyr Gln Glu Val Phe Gly Arg Leu Arg Asp Glu Asn Gly Arg 
705                 710                 715                 720 


Pro Tyr Ser Pro Ser Gln Tyr Ala Leu Gln Tyr Ala Gly Asp Gly Ser 
                725                 730                 735     


Val Leu Leu Ile Pro Arg Thr Met Ala Asp Gln Gln Ala Arg Arg Gln 
            740                 745                 750         


Glu Arg Lys Pro Lys Asp Arg Arg Lys 
        755                 760     


<210>  9335
<211>  742
<212>  PRT
<213>  Homo Sapiens

<400>  9335

Met Leu Ser Leu Lys Lys Tyr Leu Thr Glu Gly Leu Leu Gln Phe Thr 
1               5                   10                  15      


Ile Leu Leu Ser Leu Ile Gly Val Arg Val Asp Val Asp Thr Tyr Leu 
            20                  25                  30          


Thr Ser Gln Leu Pro Pro Leu Arg Glu Ile Ile Leu Gly Pro Ser Ser 
        35                  40                  45              


Ala Tyr Thr Gln Thr Gln Phe His Asn Leu Arg Asn Thr Leu Asp Gly 
    50                  55                  60                  


Tyr Gly Ile His Pro Lys Ser Ile Asp Leu Asp Asn Tyr Phe Thr Ala 
65                  70                  75                  80  


Arg Arg Leu Leu Ser Gln Val Arg Ala Leu Asp Arg Phe Gln Val Pro 
                85                  90                  95      


Thr Thr Glu Val Asn Ala Trp Leu Val His Arg Asp Pro Glu Gly Ser 
            100                 105                 110         


Val Ser Gly Ser Gln Pro Asn Ser Gly Leu Ala Leu Glu Ser Ser Ser 
        115                 120                 125             


Gly Leu Gln Asp Val Thr Gly Pro Asp Asn Gly Val Arg Glu Ser Glu 
    130                 135                 140                 


Thr Glu Gln Gly Phe Gly Glu Asp Leu Glu Asp Leu Gly Ala Val Ala 
145                 150                 155                 160 


Pro Pro Val Ser Gly Asp Leu Thr Lys Glu Asp Ile Asp Leu Ile Asp 
                165                 170                 175     


Ile Leu Trp Arg Gln Asp Ile Asp Leu Gly Ala Gly Arg Glu Val Phe 
            180                 185                 190         


Asp Tyr Ser His Arg Gln Lys Glu Gln Asp Val Glu Lys Glu Leu Arg 
        195                 200                 205             


Asp Gly Gly Glu Gln Asp Thr Trp Ala Gly Glu Gly Ala Glu Ala Leu 
    210                 215                 220                 


Ala Arg Asn Leu Leu Val Asp Gly Glu Thr Gly Glu Ser Phe Pro Ala 
225                 230                 235                 240 


Gln Phe Pro Ala Asp Ile Ser Ser Ile Thr Glu Ala Val Pro Ser Glu 
                245                 250                 255     


Ser Glu Pro Pro Ala Leu Gln Asn Asn Leu Leu Ser Pro Leu Leu Thr 
            260                 265                 270         


Gly Thr Glu Ser Pro Phe Asp Leu Glu Gln Gln Trp Gln Asp Leu Met 
        275                 280                 285             


Ser Ile Met Glu Met Gln Ala Met Glu Val Asn Thr Ser Ala Ser Glu 
    290                 295                 300                 


Ile Leu Tyr Ser Ala Pro Pro Gly Asp Pro Leu Ser Thr Asn Tyr Ser 
305                 310                 315                 320 


Leu Ala Pro Asn Thr Pro Ile Asn Gln Asn Val Ser Leu His Gln Ala 
                325                 330                 335     


Ser Leu Gly Gly Cys Ser Gln Asp Phe Leu Leu Phe Ser Pro Glu Val 
            340                 345                 350         


Glu Ser Leu Pro Val Ala Ser Ser Ser Thr Leu Leu Pro Leu Ala Pro 
        355                 360                 365             


Ser Asn Ser Thr Ser Leu Asn Ser Thr Phe Gly Ser Thr Asn Leu Thr 
    370                 375                 380                 


Gly Leu Phe Phe Pro Pro Gln Leu Asn Gly Thr Ala Asn Asp Thr Ala 
385                 390                 395                 400 


Gly Pro Glu Leu Pro Asp Pro Leu Gly Gly Leu Leu Asp Glu Ala Met 
                405                 410                 415     


Leu Asp Glu Ile Ser Leu Met Asp Leu Ala Ile Glu Glu Gly Phe Asn 
            420                 425                 430         


Pro Val Gln Ala Ser Gln Leu Glu Glu Glu Phe Asp Ser Asp Ser Gly 
        435                 440                 445             


Leu Ser Leu Asp Ser Ser His Ser Pro Ser Ser Leu Ser Ser Ser Glu 
    450                 455                 460                 


Gly Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ala 
465                 470                 475                 480 


Ser Ser Ser Ala Ser Ser Ser Phe Ser Glu Glu Gly Ala Val Gly Tyr 
                485                 490                 495     


Ser Ser Asp Ser Glu Thr Leu Asp Leu Glu Glu Ala Glu Gly Ala Val 
            500                 505                 510         


Gly Tyr Gln Pro Glu Tyr Ser Lys Phe Cys Arg Met Ser Tyr Gln Asp 
        515                 520                 525             


Pro Ala Gln Leu Ser Cys Leu Pro Tyr Leu Glu His Val Gly His Asn 
    530                 535                 540                 


His Thr Tyr Asn Met Ala Pro Ser Ala Leu Asp Ser Ala Asp Leu Pro 
545                 550                 555                 560 


Pro Pro Ser Ala Leu Lys Lys Gly Ser Lys Glu Lys Gln Ala Asp Phe 
                565                 570                 575     


Leu Asp Lys Gln Met Ser Arg Asp Glu His Arg Ala Arg Ala Met Lys 
            580                 585                 590         


Ile Pro Phe Thr Asn Asp Lys Ile Ile Asn Leu Pro Val Glu Glu Phe 
        595                 600                 605             


Asn Glu Leu Leu Ser Lys Tyr Gln Leu Ser Glu Ala Gln Leu Ser Leu 
    610                 615                 620                 


Ile Arg Asp Ile Arg Arg Arg Gly Lys Asn Lys Met Ala Ala Gln Asn 
625                 630                 635                 640 


Cys Arg Lys Arg Lys Leu Asp Thr Ile Leu Asn Leu Glu Arg Asp Val 
                645                 650                 655     


Glu Asp Leu Gln Arg Asp Lys Ala Arg Leu Leu Arg Glu Lys Val Glu 
            660                 665                 670         


Phe Leu Arg Ser Leu Arg Gln Met Lys Gln Lys Val Gln Ser Leu Tyr 
        675                 680                 685             


Gln Glu Val Phe Gly Arg Leu Arg Asp Glu Asn Gly Arg Pro Tyr Ser 
    690                 695                 700                 


Pro Ser Gln Tyr Ala Leu Gln Tyr Ala Gly Asp Gly Ser Val Leu Leu 
705                 710                 715                 720 


Ile Pro Arg Thr Met Ala Asp Gln Gln Ala Arg Arg Gln Glu Arg Lys 
                725                 730                 735     


Pro Lys Asp Arg Arg Lys 
            740         


<210>  9336
<211>  742
<212>  PRT
<213>  Homo Sapiens

<400>  9336

Met Leu Ser Leu Lys Lys Tyr Leu Thr Glu Gly Leu Leu Gln Phe Thr 
1               5                   10                  15      


Ile Leu Leu Ser Leu Ile Gly Val Arg Val Asp Val Asp Thr Tyr Leu 
            20                  25                  30          


Thr Ser Gln Leu Pro Pro Leu Arg Glu Ile Ile Leu Gly Pro Ser Ser 
        35                  40                  45              


Ala Tyr Thr Gln Thr Gln Phe His Asn Leu Arg Asn Thr Leu Asp Gly 
    50                  55                  60                  


Tyr Gly Ile His Pro Lys Ser Ile Asp Leu Asp Asn Tyr Phe Thr Ala 
65                  70                  75                  80  


Arg Arg Leu Leu Ser Gln Val Arg Ala Leu Asp Arg Phe Gln Val Pro 
                85                  90                  95      


Thr Thr Glu Val Asn Ala Trp Leu Val His Arg Asp Pro Glu Gly Ser 
            100                 105                 110         


Val Ser Gly Ser Gln Pro Asn Ser Gly Leu Ala Leu Glu Ser Ser Ser 
        115                 120                 125             


Gly Leu Gln Asp Val Thr Gly Pro Asp Asn Gly Val Arg Glu Ser Glu 
    130                 135                 140                 


Thr Glu Gln Gly Phe Gly Glu Asp Leu Glu Asp Leu Gly Ala Val Ala 
145                 150                 155                 160 


Pro Pro Val Ser Gly Asp Leu Thr Lys Glu Asp Ile Asp Leu Ile Asp 
                165                 170                 175     


Ile Leu Trp Arg Gln Asp Ile Asp Leu Gly Ala Gly Arg Glu Val Phe 
            180                 185                 190         


Asp Tyr Ser His Arg Gln Lys Glu Gln Asp Val Glu Lys Glu Leu Arg 
        195                 200                 205             


Asp Gly Gly Glu Gln Asp Thr Trp Ala Gly Glu Gly Ala Glu Ala Leu 
    210                 215                 220                 


Ala Arg Asn Leu Leu Val Asp Gly Glu Thr Gly Glu Ser Phe Pro Ala 
225                 230                 235                 240 


Gln Phe Pro Ala Asp Ile Ser Ser Ile Thr Glu Ala Val Pro Ser Glu 
                245                 250                 255     


Ser Glu Pro Pro Ala Leu Gln Asn Asn Leu Leu Ser Pro Leu Leu Thr 
            260                 265                 270         


Gly Thr Glu Ser Pro Phe Asp Leu Glu Gln Gln Trp Gln Asp Leu Met 
        275                 280                 285             


Ser Ile Met Glu Met Gln Ala Met Glu Val Asn Thr Ser Ala Ser Glu 
    290                 295                 300                 


Ile Leu Tyr Ser Ala Pro Pro Gly Asp Pro Leu Ser Thr Asn Tyr Ser 
305                 310                 315                 320 


Leu Ala Pro Asn Thr Pro Ile Asn Gln Asn Val Ser Leu His Gln Ala 
                325                 330                 335     


Ser Leu Gly Gly Cys Ser Gln Asp Phe Leu Leu Phe Ser Pro Glu Val 
            340                 345                 350         


Glu Ser Leu Pro Val Ala Ser Ser Ser Thr Leu Leu Pro Leu Ala Pro 
        355                 360                 365             


Ser Asn Ser Thr Ser Leu Asn Ser Thr Phe Gly Ser Thr Asn Leu Thr 
    370                 375                 380                 


Gly Leu Phe Phe Pro Pro Gln Leu Asn Gly Thr Ala Asn Asp Thr Ala 
385                 390                 395                 400 


Gly Pro Glu Leu Pro Asp Pro Leu Gly Gly Leu Leu Asp Glu Ala Met 
                405                 410                 415     


Leu Asp Glu Ile Ser Leu Met Asp Leu Ala Ile Glu Glu Gly Phe Asn 
            420                 425                 430         


Pro Val Gln Ala Ser Gln Leu Glu Glu Glu Phe Asp Ser Asp Ser Gly 
        435                 440                 445             


Leu Ser Leu Asp Ser Ser His Ser Pro Ser Ser Leu Ser Ser Ser Glu 
    450                 455                 460                 


Gly Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ala 
465                 470                 475                 480 


Ser Ser Ser Ala Ser Ser Ser Phe Ser Glu Glu Gly Ala Val Gly Tyr 
                485                 490                 495     


Ser Ser Asp Ser Glu Thr Leu Asp Leu Glu Glu Ala Glu Gly Ala Val 
            500                 505                 510         


Gly Tyr Gln Pro Glu Tyr Ser Lys Phe Cys Arg Met Ser Tyr Gln Asp 
        515                 520                 525             


Pro Ala Gln Leu Ser Cys Leu Pro Tyr Leu Glu His Val Gly His Asn 
    530                 535                 540                 


His Thr Tyr Asn Met Ala Pro Ser Ala Leu Asp Ser Ala Asp Leu Pro 
545                 550                 555                 560 


Pro Pro Ser Ala Leu Lys Lys Gly Ser Lys Glu Lys Gln Ala Asp Phe 
                565                 570                 575     


Leu Asp Lys Gln Met Ser Arg Asp Glu His Arg Ala Arg Ala Met Lys 
            580                 585                 590         


Ile Pro Phe Thr Asn Asp Lys Ile Ile Asn Leu Pro Val Glu Glu Phe 
        595                 600                 605             


Asn Glu Leu Leu Ser Lys Tyr Gln Leu Ser Glu Ala Gln Leu Ser Leu 
    610                 615                 620                 


Ile Arg Asp Ile Arg Arg Arg Gly Lys Asn Lys Met Ala Ala Gln Asn 
625                 630                 635                 640 


Cys Arg Lys Arg Lys Leu Asp Thr Ile Leu Asn Leu Glu Arg Asp Val 
                645                 650                 655     


Glu Asp Leu Gln Arg Asp Lys Ala Arg Leu Leu Arg Glu Lys Val Glu 
            660                 665                 670         


Phe Leu Arg Ser Leu Arg Gln Met Lys Gln Lys Val Gln Ser Leu Tyr 
        675                 680                 685             


Gln Glu Val Phe Gly Arg Leu Arg Asp Glu Asn Gly Arg Pro Tyr Ser 
    690                 695                 700                 


Pro Ser Gln Tyr Ala Leu Gln Tyr Ala Gly Asp Gly Ser Val Leu Leu 
705                 710                 715                 720 


Ile Pro Arg Thr Met Ala Asp Gln Gln Ala Arg Arg Gln Glu Arg Lys 
                725                 730                 735     


Pro Lys Asp Arg Arg Lys 
            740         


<210>  9337
<211>  772
<212>  PRT
<213>  Homo Sapiens

<400>  9337

Met Leu Ser Leu Lys Lys Tyr Leu Thr Glu Gly Leu Leu Gln Phe Thr 
1               5                   10                  15      


Ile Leu Leu Ser Leu Ile Gly Val Arg Val Asp Val Asp Thr Tyr Leu 
            20                  25                  30          


Thr Ser Gln Leu Pro Pro Leu Arg Glu Ile Ile Leu Gly Pro Ser Ser 
        35                  40                  45              


Ala Tyr Thr Gln Thr Gln Phe His Asn Leu Arg Asn Thr Leu Asp Gly 
    50                  55                  60                  


Tyr Gly Ile His Pro Lys Ser Ile Asp Leu Asp Asn Tyr Phe Thr Ala 
65                  70                  75                  80  


Arg Arg Leu Leu Ser Gln Val Arg Ala Leu Asp Arg Phe Gln Val Pro 
                85                  90                  95      


Thr Thr Glu Val Asn Ala Trp Leu Val His Arg Asp Pro Glu Gly Ser 
            100                 105                 110         


Val Ser Gly Ser Gln Pro Asn Ser Gly Leu Ala Leu Glu Ser Ser Ser 
        115                 120                 125             


Gly Leu Gln Asp Val Thr Gly Pro Asp Asn Gly Val Arg Glu Ser Glu 
    130                 135                 140                 


Thr Glu Gln Gly Phe Gly Glu Asp Leu Glu Asp Leu Gly Ala Val Ala 
145                 150                 155                 160 


Pro Pro Val Ser Gly Asp Leu Thr Lys Glu Asp Ile Asp Leu Ile Asp 
                165                 170                 175     


Ile Leu Trp Arg Gln Asp Ile Asp Leu Gly Ala Gly Arg Glu Val Phe 
            180                 185                 190         


Asp Tyr Ser His Arg Gln Lys Glu Gln Asp Val Glu Lys Glu Leu Arg 
        195                 200                 205             


Asp Gly Gly Glu Gln Asp Thr Trp Ala Gly Glu Gly Ala Glu Ala Leu 
    210                 215                 220                 


Ala Arg Asn Leu Leu Val Asp Gly Glu Thr Gly Glu Ser Phe Pro Ala 
225                 230                 235                 240 


Gln Val Pro Ser Gly Glu Asp Gln Thr Ala Leu Ser Leu Glu Glu Cys 
                245                 250                 255     


Leu Arg Leu Leu Glu Ala Thr Cys Pro Phe Gly Glu Asn Ala Glu Phe 
            260                 265                 270         


Pro Ala Asp Ile Ser Ser Ile Thr Glu Ala Val Pro Ser Glu Ser Glu 
        275                 280                 285             


Pro Pro Ala Leu Gln Asn Asn Leu Leu Ser Pro Leu Leu Thr Gly Thr 
    290                 295                 300                 


Glu Ser Pro Phe Asp Leu Glu Gln Gln Trp Gln Asp Leu Met Ser Ile 
305                 310                 315                 320 


Met Glu Met Gln Ala Met Glu Val Asn Thr Ser Ala Ser Glu Ile Leu 
                325                 330                 335     


Tyr Ser Ala Pro Pro Gly Asp Pro Leu Ser Thr Asn Tyr Ser Leu Ala 
            340                 345                 350         


Pro Asn Thr Pro Ile Asn Gln Asn Val Ser Leu His Gln Ala Ser Leu 
        355                 360                 365             


Gly Gly Cys Ser Gln Asp Phe Leu Leu Phe Ser Pro Glu Val Glu Ser 
    370                 375                 380                 


Leu Pro Val Ala Ser Ser Ser Thr Leu Leu Pro Leu Ala Pro Ser Asn 
385                 390                 395                 400 


Ser Thr Ser Leu Asn Ser Thr Phe Gly Ser Thr Asn Leu Thr Gly Leu 
                405                 410                 415     


Phe Phe Pro Pro Gln Leu Asn Gly Thr Ala Asn Asp Thr Ala Gly Pro 
            420                 425                 430         


Glu Leu Pro Asp Pro Leu Gly Gly Leu Leu Asp Glu Ala Met Leu Asp 
        435                 440                 445             


Glu Ile Ser Leu Met Asp Leu Ala Ile Glu Glu Gly Phe Asn Pro Val 
    450                 455                 460                 


Gln Ala Ser Gln Leu Glu Glu Glu Phe Asp Ser Asp Ser Gly Leu Ser 
465                 470                 475                 480 


Leu Asp Ser Ser His Ser Pro Ser Ser Leu Ser Ser Ser Glu Gly Ser 
                485                 490                 495     


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ala Ser Ser 
            500                 505                 510         


Ser Ala Ser Ser Ser Phe Ser Glu Glu Gly Ala Val Gly Tyr Ser Ser 
        515                 520                 525             


Asp Ser Glu Thr Leu Asp Leu Glu Glu Ala Glu Gly Ala Val Gly Tyr 
    530                 535                 540                 


Gln Pro Glu Tyr Ser Lys Phe Cys Arg Met Ser Tyr Gln Asp Pro Ala 
545                 550                 555                 560 


Gln Leu Ser Cys Leu Pro Tyr Leu Glu His Val Gly His Asn His Thr 
                565                 570                 575     


Tyr Asn Met Ala Pro Ser Ala Leu Asp Ser Ala Asp Leu Pro Pro Pro 
            580                 585                 590         


Ser Ala Leu Lys Lys Gly Ser Lys Glu Lys Gln Ala Asp Phe Leu Asp 
        595                 600                 605             


Lys Gln Met Ser Arg Asp Glu His Arg Ala Arg Ala Met Lys Ile Pro 
    610                 615                 620                 


Phe Thr Asn Asp Lys Ile Ile Asn Leu Pro Val Glu Glu Phe Asn Glu 
625                 630                 635                 640 


Leu Leu Ser Lys Tyr Gln Leu Ser Glu Ala Gln Leu Ser Leu Ile Arg 
                645                 650                 655     


Asp Ile Arg Arg Arg Gly Lys Asn Lys Met Ala Ala Gln Asn Cys Arg 
            660                 665                 670         


Lys Arg Lys Leu Asp Thr Ile Leu Asn Leu Glu Arg Asp Val Glu Asp 
        675                 680                 685             


Leu Gln Arg Asp Lys Ala Arg Leu Leu Arg Glu Lys Val Glu Phe Leu 
    690                 695                 700                 


Arg Ser Leu Arg Gln Met Lys Gln Lys Val Gln Ser Leu Tyr Gln Glu 
705                 710                 715                 720 


Val Phe Gly Arg Leu Arg Asp Glu Asn Gly Arg Pro Tyr Ser Pro Ser 
                725                 730                 735     


Gln Tyr Ala Leu Gln Tyr Ala Gly Asp Gly Ser Val Leu Leu Ile Pro 
            740                 745                 750         


Arg Thr Met Ala Asp Gln Gln Ala Arg Arg Gln Glu Arg Lys Pro Lys 
        755                 760                 765             


Asp Arg Arg Lys 
    770         


<210>  9338
<211>  19
<212>  PRT
<213>  Homo Sapiens

<400>  9338

Met Ser Ile Met Glu Met Gln Ala Met Glu Val Asn Thr Ser Ala Ser 
1               5                   10                  15      


Glu Ile Leu 
            


<210>  9339
<211>  23
<212>  PRT
<213>  Homo Sapiens

<400>  9339

Met Ser Ile Met Glu Met Gln Ala Met Glu Val Asn Thr Ser Ala Ser 
1               5                   10                  15      


Glu Ile Leu Tyr Ser Ala Pro 
            20              


<210>  9340
<211>  47
<212>  PRT
<213>  Homo Sapiens

<400>  9340

Met Ser Ile Met Glu Met Gln Ala Met Glu Val Asn Thr Ser Ala Ser 
1               5                   10                  15      


Glu Ile Leu Tyr Ser Ala Pro Pro Gly Asp Pro Leu Ser Thr Asn Tyr 
            20                  25                  30          


Ser Leu Ala Pro Asn Thr Pro Ile Asn Gln Asn Val Ser Leu His 
        35                  40                  45          


<210>  9341
<211>  63
<212>  PRT
<213>  Homo Sapiens

<400>  9341

Met Ser Ile Met Glu Met Gln Ala Met Glu Val Asn Thr Ser Ala Ser 
1               5                   10                  15      


Glu Ile Leu Tyr Ser Ala Pro Pro Gly Asp Pro Leu Ser Thr Asn Tyr 
            20                  25                  30          


Ser Leu Ala Pro Asn Thr Pro Ile Asn Gln Asn Val Ser Leu His Gln 
        35                  40                  45              


Ala Ser Leu Gly Gly Cys Ser Gln Asp Phe Leu Leu Phe Ser Pro 
    50                  55                  60              


<210>  9342
<211>  161
<212>  PRT
<213>  Homo Sapiens

<400>  9342

Met Thr Arg Leu Asp Arg Ser Ser His Ser Gly Gly Gly His Ala Lys 
1               5                   10                  15      


Gly Ser Arg Pro Leu Asn Ser Leu Leu Ala Gly His Arg Val Ala Gln 
            20                  25                  30          


Pro Ala Ser Ala Pro Gly Ser Arg Ala Ser Val Gln Asp Ile Asp Leu 
        35                  40                  45              


Gly Ala Gly Arg Glu Val Phe Asp Tyr Ser His Arg Gln Lys Glu Gln 
    50                  55                  60                  


Asp Val Glu Lys Glu Leu Arg Asp Gly Gly Glu Gln Asp Thr Trp Ala 
65                  70                  75                  80  


Gly Glu Gly Ala Glu Ala Leu Ala Arg Asn Leu Leu Val Asp Gly Glu 
                85                  90                  95      


Thr Gly Glu Ser Phe Pro Ala Gln Phe Pro Ala Asp Ile Ser Ser Ile 
            100                 105                 110         


Thr Glu Ala Val Pro Ser Glu Ser Glu Pro Pro Ala Leu Gln Asn Asn 
        115                 120                 125             


Leu Leu Ser Pro Leu Leu Thr Gly Thr Glu Ser Pro Phe Asp Leu Glu 
    130                 135                 140                 


Gln Gln Trp Gln Asp Leu Met Ser Ile Met Glu Met Gln Ala Met Glu 
145                 150                 155                 160 


Val 
    


<210>  9343
<211>  63
<212>  PRT
<213>  Homo Sapiens

<400>  9343

Met Thr Arg Leu Asp Arg Ser Ser His Ser Gly Gly Gly His Ala Lys 
1               5                   10                  15      


Gly Ser Arg Pro Leu Asn Ser Leu Leu Ala Gly His Arg Val Ala Gln 
            20                  25                  30          


Pro Ala Ser Ala Pro Gly Ser Arg Ala Ser Val Gln Asp Ile Asp Leu 
        35                  40                  45              


Ile Asp Ile Leu Trp Arg Gln Asp Ile Asp Leu Gly Ala Gly Arg 
    50                  55                  60              


<210>  9344
<211>  111
<212>  PRT
<213>  Homo Sapiens

<400>  9344

Met Thr Arg Leu Asp Arg Ser Ser His Ser Gly Gly Gly His Ala Lys 
1               5                   10                  15      


Gly Ser Arg Pro Leu Asn Ser Leu Leu Ala Gly His Arg Val Ala Gln 
            20                  25                  30          


Pro Ala Ser Ala Pro Gly Ser Arg Ala Ser Val Gln Asp Ile Asp Leu 
        35                  40                  45              


Ile Asp Ile Leu Trp Arg Gln Asp Ile Asp Leu Gly Ala Gly Arg Glu 
    50                  55                  60                  


Val Phe Asp Tyr Ser His Arg Gln Lys Glu Gln Asp Val Glu Lys Glu 
65                  70                  75                  80  


Leu Arg Asp Gly Gly Glu Gln Asp Thr Trp Ala Gly Glu Gly Ala Glu 
                85                  90                  95      


Ala Leu Ala Arg Asn Leu Leu Val Asp Gly Glu Thr Gly Glu Ser 
            100                 105                 110     


<210>  9345
<211>  616
<212>  PRT
<213>  Homo Sapiens

<400>  9345

Met Thr Arg Leu Asp Arg Ser Ser His Ser Gly Gly Gly His Ala Lys 
1               5                   10                  15      


Gly Ser Arg Pro Leu Asn Ser Leu Leu Ala Gly His Arg Val Ala Gln 
            20                  25                  30          


Pro Ala Ser Ala Pro Gly Ser Arg Ala Ser Val Gln Asp Ile Asp Leu 
        35                  40                  45              


Ile Asp Ile Leu Trp Arg Gln Asp Ile Asp Leu Gly Ala Gly Arg Glu 
    50                  55                  60                  


Val Phe Asp Tyr Ser His Arg Gln Lys Glu Gln Asp Val Glu Lys Glu 
65                  70                  75                  80  


Leu Arg Asp Gly Gly Glu Gln Asp Thr Trp Ala Gly Glu Gly Ala Glu 
                85                  90                  95      


Ala Leu Ala Arg Asn Leu Leu Val Asp Gly Glu Thr Gly Glu Ser Phe 
            100                 105                 110         


Pro Ala Gln Phe Pro Ala Asp Ile Ser Ser Ile Thr Glu Ala Val Pro 
        115                 120                 125             


Ser Glu Ser Glu Pro Pro Ala Leu Gln Asn Asn Leu Leu Ser Pro Leu 
    130                 135                 140                 


Leu Thr Gly Thr Glu Ser Pro Phe Asp Leu Glu Gln Gln Trp Gln Asp 
145                 150                 155                 160 


Leu Met Ser Ile Met Glu Met Gln Ala Met Glu Val Asn Thr Ser Ala 
                165                 170                 175     


Ser Glu Ile Leu Tyr Ser Ala Pro Pro Gly Asp Pro Leu Ser Thr Asn 
            180                 185                 190         


Tyr Ser Leu Ala Pro Asn Thr Pro Ile Asn Gln Asn Val Ser Leu His 
        195                 200                 205             


Gln Ala Ser Leu Gly Gly Cys Ser Gln Asp Phe Leu Leu Phe Ser Pro 
    210                 215                 220                 


Glu Val Glu Ser Leu Pro Val Ala Ser Ser Ser Thr Leu Leu Pro Leu 
225                 230                 235                 240 


Ala Pro Ser Asn Ser Thr Ser Leu Asn Ser Thr Phe Gly Ser Thr Asn 
                245                 250                 255     


Leu Thr Gly Leu Phe Phe Pro Pro Gln Leu Asn Gly Thr Ala Asn Asp 
            260                 265                 270         


Thr Ala Gly Pro Glu Leu Pro Asp Pro Leu Gly Gly Leu Leu Asp Glu 
        275                 280                 285             


Ala Met Leu Asp Glu Ile Ser Leu Met Asp Leu Ala Ile Glu Glu Gly 
    290                 295                 300                 


Phe Asn Pro Val Gln Ala Ser Gln Leu Glu Glu Glu Phe Asp Ser Asp 
305                 310                 315                 320 


Ser Gly Leu Ser Leu Asp Ser Ser His Ser Pro Ser Ser Leu Ser Ser 
                325                 330                 335     


Ser Glu Gly Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
            340                 345                 350         


Ser Ala Ser Ser Ser Ala Ser Ser Ser Phe Ser Glu Glu Gly Ala Val 
        355                 360                 365             


Gly Tyr Ser Ser Asp Ser Glu Thr Leu Asp Leu Glu Glu Ala Glu Gly 
    370                 375                 380                 


Ala Val Gly Tyr Gln Pro Glu Tyr Ser Lys Phe Cys Arg Met Ser Tyr 
385                 390                 395                 400 


Gln Asp Pro Ala Gln Leu Ser Cys Leu Pro Tyr Leu Glu His Val Gly 
                405                 410                 415     


His Asn His Thr Tyr Asn Met Ala Pro Ser Ala Leu Asp Ser Ala Asp 
            420                 425                 430         


Leu Pro Pro Pro Ser Ala Leu Lys Lys Gly Ser Lys Glu Lys Gln Ala 
        435                 440                 445             


Asp Phe Leu Asp Lys Gln Met Ser Arg Asp Glu His Arg Ala Arg Ala 
    450                 455                 460                 


Met Lys Ile Pro Phe Thr Asn Asp Lys Ile Ile Asn Leu Pro Val Glu 
465                 470                 475                 480 


Glu Phe Asn Glu Leu Leu Ser Lys Tyr Gln Leu Ser Glu Ala Gln Leu 
                485                 490                 495     


Ser Leu Ile Arg Asp Ile Arg Arg Arg Gly Lys Asn Lys Met Ala Ala 
            500                 505                 510         


Gln Asn Cys Arg Lys Arg Lys Leu Asp Thr Ile Leu Asn Leu Glu Arg 
        515                 520                 525             


Asp Val Glu Asp Leu Gln Arg Asp Lys Ala Arg Leu Leu Arg Glu Lys 
    530                 535                 540                 


Val Glu Phe Leu Arg Ser Leu Arg Gln Met Lys Gln Lys Val Gln Ser 
545                 550                 555                 560 


Leu Tyr Gln Glu Val Phe Gly Arg Leu Arg Asp Glu Asn Gly Arg Pro 
                565                 570                 575     


Tyr Ser Pro Ser Gln Tyr Ala Leu Gln Tyr Ala Gly Asp Gly Ser Val 
            580                 585                 590         


Leu Leu Ile Pro Arg Thr Met Ala Asp Gln Gln Ala Arg Arg Gln Glu 
        595                 600                 605             


Arg Lys Pro Lys Asp Arg Arg Lys 
    610                 615     


<210>  9346
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  9346

Ser Glu Glu Gly Ala Val Gly Tyr Ser Ser Asp Ser Glu Thr Leu Asp 
1               5                   10                  15      


Leu Glu Glu Ala Glu Gly Ala Val Gly Tyr Gln Pro Glu Tyr Ser Lys 
            20                  25                  30          


Phe Cys Arg Met Ser Tyr Gln Asp Pro Ala Gln Leu Ser Cys Leu Pro 
        35                  40                  45              


Tyr Leu Glu His Val Gly His Asn His Thr Tyr Asn Met Ala Pro Ser 
    50                  55                  60                  


Ala Leu Asp Ser Ala Asp Leu Pro Pro Pro Ser Ala Leu Lys Lys Gly 
65                  70                  75                  80  


Ser Lys Glu Lys Gln Ala Asp Phe Leu Asp Lys Gln Met Ser Arg Asp 
                85                  90                  95      


Glu His Arg Ala Arg Ala Met Lys Ile Pro Phe Thr Asn Asp Lys Ile 
            100                 105                 110         


Ile Asn Leu Pro Val Glu Glu Leu Cys Gly Ala Lys Ala Asp Arg Gly 
        115                 120                 125             


Glu Gly Met Asp Leu 
    130             


<210>  9347
<211>  694
<212>  PRT
<213>  Homo Sapiens

<400>  9347

Met Lys His Leu Lys Arg Trp Trp Ser Ala Gly Gly Gly Leu Leu His 
1               5                   10                  15      


Leu Thr Leu Leu Leu Ser Leu Ala Gly Leu Arg Val Asp Leu Asp Leu 
            20                  25                  30          


Tyr Leu Leu Leu Pro Pro Pro Thr Leu Leu Gln Asp Glu Leu Leu Phe 
        35                  40                  45              


Leu Gly Gly Pro Ala Ser Ser Ala Tyr Ala Leu Ser Pro Phe Ser Ala 
    50                  55                  60                  


Ser Gly Gly Trp Gly Arg Ala Gly His Leu His Pro Lys Gly Arg Glu 
65                  70                  75                  80  


Leu Asp Pro Ala Ala Pro Pro Glu Gly Gln Leu Leu Arg Glu Val Arg 
                85                  90                  95      


Ala Leu Gly Val Pro Phe Val Pro Arg Thr Ser Val Asp Ala Trp Leu 
            100                 105                 110         


Val His Ser Val Ala Ala Gly Ser Ala Asp Glu Ala His Gly Leu Leu 
        115                 120                 125             


Gly Ala Ala Ala Ala Ser Ser Thr Gly Gly Ala Gly Ala Ser Val Asp 
    130                 135                 140                 


Gly Gly Ser Gln Ala Val Gln Gly Gly Gly Gly Asp Pro Arg Ala Ala 
145                 150                 155                 160 


Arg Ser Gly Pro Leu Asp Ala Gly Glu Glu Glu Lys Ala Pro Ala Glu 
                165                 170                 175     


Pro Thr Ala Gln Val Pro Asp Ala Gly Gly Cys Ala Ser Glu Glu Asn 
            180                 185                 190         


Gly Val Leu Arg Glu Lys His Glu Ala Val Asp His Ser Ser Gln His 
        195                 200                 205             


Glu Glu Asn Glu Glu Arg Val Ser Ala Gln Lys Glu Asn Ser Leu Gln 
    210                 215                 220                 


Gln Asn Asp Asp Asp Glu Asn Lys Ile Ala Glu Lys Pro Asp Trp Glu 
225                 230                 235                 240 


Ala Glu Lys Thr Thr Glu Ser Arg Asn Glu Arg His Leu Asn Gly Thr 
                245                 250                 255     


Asp Thr Ser Phe Ser Leu Glu Asp Leu Phe Gln Leu Leu Ser Ser Gln 
            260                 265                 270         


Pro Glu Asn Ser Leu Glu Gly Ile Ser Leu Gly Asp Ile Pro Leu Pro 
        275                 280                 285             


Gly Ser Ile Ser Asp Gly Met Asn Ser Ser Ala His Tyr His Val Asn 
    290                 295                 300                 


Phe Ser Gln Ala Ile Ser Gln Asp Val Asn Leu His Glu Ala Ile Leu 
305                 310                 315                 320 


Leu Cys Pro Asn Asn Thr Phe Arg Arg Asp Pro Thr Ala Arg Thr Ser 
                325                 330                 335     


Gln Ser Gln Glu Pro Phe Leu Gln Leu Asn Ser His Thr Thr Asn Pro 
            340                 345                 350         


Glu Gln Thr Leu Pro Gly Thr Asn Leu Thr Gly Phe Leu Ser Pro Val 
        355                 360                 365             


Asp Asn His Met Arg Asn Leu Thr Ser Gln Asp Leu Leu Tyr Asp Leu 
    370                 375                 380                 


Asp Ile Asn Ile Phe Asp Glu Ile Asn Leu Met Ser Leu Ala Thr Glu 
385                 390                 395                 400 


Asp Asn Phe Asp Pro Ile Asp Val Ser Gln Leu Phe Asp Glu Pro Asp 
                405                 410                 415     


Ser Asp Ser Gly Leu Ser Leu Asp Ser Ser His Asn Asn Thr Ser Val 
            420                 425                 430         


Ile Lys Ser Asn Ser Ser His Ser Val Cys Asp Glu Gly Ala Ile Gly 
        435                 440                 445             


Tyr Cys Thr Asp His Glu Ser Ser Ser His His Asp Leu Glu Gly Ala 
    450                 455                 460                 


Val Gly Gly Tyr Tyr Pro Glu Pro Ser Lys Leu Cys His Leu Asp Gln 
465                 470                 475                 480 


Ser Asp Ser Asp Phe His Gly Asp Leu Thr Phe Gln His Val Phe His 
                485                 490                 495     


Asn His Thr Tyr His Leu Gln Pro Thr Ala Pro Glu Ser Thr Ser Glu 
            500                 505                 510         


Pro Phe Pro Trp Pro Gly Lys Ser Gln Lys Ile Arg Ser Arg Tyr Leu 
        515                 520                 525             


Glu Asp Thr Asp Arg Asn Leu Ser Arg Asp Glu Gln Arg Ala Lys Ala 
    530                 535                 540                 


Leu His Ile Pro Phe Ser Val Asp Glu Ile Val Gly Met Pro Val Asp 
545                 550                 555                 560 


Ser Phe Asn Ser Met Leu Ser Arg Tyr Tyr Leu Thr Asp Leu Gln Val 
                565                 570                 575     


Ser Leu Ile Arg Asp Ile Arg Arg Arg Gly Lys Asn Lys Val Ala Ala 
            580                 585                 590         


Gln Asn Cys Arg Lys Arg Lys Leu Asp Ile Ile Leu Asn Leu Glu Asp 
        595                 600                 605             


Asp Val Cys Asn Leu Gln Ala Lys Lys Glu Thr Leu Lys Arg Glu Gln 
    610                 615                 620                 


Ala Gln Cys Asn Lys Ala Ile Asn Ile Met Lys Gln Lys Leu His Asp 
625                 630                 635                 640 


Leu Tyr His Asp Ile Phe Ser Arg Leu Arg Asp Asp Gln Gly Arg Pro 
                645                 650                 655     


Val Asn Pro Asn His Tyr Ala Leu Gln Cys Thr His Asp Gly Ser Ile 
            660                 665                 670         


Leu Ile Val Pro Lys Glu Leu Val Ala Ser Gly His Lys Lys Glu Thr 
        675                 680                 685             


Gln Lys Gly Lys Arg Lys 
    690                 


<210>  9348
<211>  83
<212>  PRT
<213>  Homo Sapiens

<400>  9348

Asn Glu Glu Arg Val Ser Ala Gln Lys Glu Asn Ser Leu Gln Gln Asn 
1               5                   10                  15      


Asp Asp Asp Glu Asn Lys Ile Ala Glu Lys Pro Asp Trp Glu Ala Glu 
            20                  25                  30          


Lys Thr Thr Glu Ser Arg Asn Glu Arg His Leu Asn Gly Thr Asp Thr 
        35                  40                  45              


Ser Phe Ser Leu Glu Asp Leu Phe Gln Leu Leu Ser Ser Gln Pro Glu 
    50                  55                  60                  


Asn Ser Leu Glu Val Ile Gly Thr Leu Ala Phe Ile Leu Ala Gly Thr 
65                  70                  75                  80  


Tyr Leu His 
            


<210>  9349
<211>  238
<212>  PRT
<213>  Homo Sapiens

<400>  9349

Met Glu Leu Leu Ala Ala Ala Phe Ser Ala Ala Cys Ala Val Asp His 
1               5                   10                  15      


Asp Ser Ser Thr Ser Glu Ser Asp Ala Arg Asp Ser Ala Ala Gly His 
            20                  25                  30          


Leu Pro Gly Ser Glu Ser Ser Ser Thr Pro Gly Asn Gly Ala Thr Pro 
        35                  40                  45              


Glu Glu Trp Pro Ala Leu Ala Asp Ser Pro Thr Thr Leu Thr Glu Ala 
    50                  55                  60                  


Leu Arg Met Ile His Pro Ile Pro Ala Asp Ser Trp Arg Asn Leu Ile 
65                  70                  75                  80  


Glu Gln Ile Gly Leu Leu Tyr Gln Glu Tyr Arg Asp Lys Ser Thr Leu 
                85                  90                  95      


Gln Glu Ile Glu Thr Arg Arg Gln Gln Asp Ala Glu Ile Glu Asp Asn 
            100                 105                 110         


Thr Asn Gly Ser Pro Ala Ser Glu Asp Thr Pro Glu Glu Glu Glu Glu 
        115                 120                 125             


Glu Glu Glu Glu Glu Glu Pro Ala Ser Pro Pro Glu Arg Lys Thr Leu 
    130                 135                 140                 


Pro Gln Ile Cys Leu Leu Ser Asn Pro His Ser Arg Phe Asn Leu Trp 
145                 150                 155                 160 


Gln Asp Leu Pro Glu Ile Arg Ser Ser Gly Val Leu Glu Ile Leu Gln 
                165                 170                 175     


Pro Glu Glu Ile Lys Leu Gln Glu Ala Met Phe Glu Leu Val Thr Ser 
            180                 185                 190         


Glu Ala Ser Tyr Tyr Lys Ser Leu Asn Leu Leu Val Ser His Phe Met 
        195                 200                 205             


Glu Asn Glu Arg Ile Arg Lys Ile Leu His Pro Ser Glu Ala His Ile 
    210                 215                 220                 


Leu Phe Ser Asn Val Leu Asp Val Leu Ala Val Ser Glu Arg 
225                 230                 235             


<210>  9350
<211>  618
<212>  PRT
<213>  Homo Sapiens

<400>  9350

Met Glu Leu Leu Ala Ala Ala Phe Ser Ala Ala Cys Ala Val Asp His 
1               5                   10                  15      


Asp Ser Ser Thr Ser Glu Ser Asp Ala Arg Asp Ser Ala Ala Gly His 
            20                  25                  30          


Leu Pro Gly Ser Glu Ser Ser Ser Thr Pro Gly Asn Gly Ala Thr Pro 
        35                  40                  45              


Glu Glu Trp Pro Ala Leu Ala Asp Ser Pro Thr Thr Leu Thr Glu Ala 
    50                  55                  60                  


Leu Arg Met Ile His Pro Ile Pro Ala Asp Ser Trp Arg Asn Leu Ile 
65                  70                  75                  80  


Glu Gln Ile Gly Leu Leu Tyr Gln Glu Tyr Arg Asp Lys Ser Thr Leu 
                85                  90                  95      


Gln Glu Ile Glu Thr Arg Arg Gln Gln Asp Ala Glu Ile Glu Asp Asn 
            100                 105                 110         


Thr Asn Gly Ser Pro Ala Ser Glu Asp Thr Pro Glu Glu Glu Glu Glu 
        115                 120                 125             


Glu Glu Glu Glu Glu Glu Pro Ala Ser Pro Pro Glu Arg Lys Thr Leu 
    130                 135                 140                 


Pro Gln Ile Cys Leu Leu Ser Asn Pro His Ser Arg Phe Asn Leu Trp 
145                 150                 155                 160 


Gln Asp Leu Pro Glu Ile Arg Ser Ser Gly Val Leu Glu Ile Leu Gln 
                165                 170                 175     


Pro Glu Glu Ile Lys Leu Gln Glu Ala Met Phe Glu Leu Val Thr Ser 
            180                 185                 190         


Glu Ala Ser Tyr Tyr Lys Ser Leu Asn Leu Leu Val Ser His Phe Met 
        195                 200                 205             


Glu Asn Glu Arg Ile Arg Lys Ile Leu His Pro Ser Glu Ala His Ile 
    210                 215                 220                 


Leu Phe Ser Asn Val Leu Asp Val Leu Ala Val Ser Glu Arg Phe Leu 
225                 230                 235                 240 


Leu Glu Leu Glu His Arg Met Glu Glu Asn Ile Val Ile Ser Asp Val 
                245                 250                 255     


Cys Asp Ile Val Tyr Arg Tyr Ala Ala Asp His Phe Ser Val Tyr Ile 
            260                 265                 270         


Thr Tyr Val Ser Asn Gln Thr Tyr Gln Glu Arg Thr Tyr Lys Gln Leu 
        275                 280                 285             


Leu Gln Glu Lys Ala Ala Phe Arg Glu Leu Ile Ala Gln Leu Glu Leu 
    290                 295                 300                 


Asp Pro Lys Cys Arg Gly Leu Pro Phe Ser Ser Phe Leu Ile Leu Pro 
305                 310                 315                 320 


Phe Gln Arg Ile Thr Arg Leu Lys Leu Leu Val Gln Asn Ile Leu Lys 
                325                 330                 335     


Arg Val Glu Glu Arg Ser Glu Arg Glu Cys Thr Ala Leu Asp Ala His 
            340                 345                 350         


Lys Glu Leu Glu Met Val Val Lys Ala Cys Asn Glu Gly Val Arg Lys 
        355                 360                 365             


Met Ser Arg Thr Glu Gln Met Ile Ser Ile Gln Lys Lys Met Glu Phe 
    370                 375                 380                 


Lys Ile Lys Ser Val Pro Ile Ile Ser His Ser Arg Trp Leu Leu Lys 
385                 390                 395                 400 


Gln Gly Glu Leu Gln Gln Met Ser Gly Pro Lys Thr Ser Arg Thr Leu 
                405                 410                 415     


Arg Thr Lys Lys Leu Phe His Glu Ile Tyr Leu Phe Leu Phe Asn Asp 
            420                 425                 430         


Leu Leu Val Ile Cys Arg Gln Ile Pro Gly Asp Lys Tyr Gln Val Phe 
        435                 440                 445             


Asp Ser Ala Pro Arg Gly Leu Leu Arg Val Glu Glu Leu Glu Asp Gln 
    450                 455                 460                 


Gly Gln Thr Leu Ala Asn Val Phe Ile Leu Arg Leu Leu Glu Asn Ala 
465                 470                 475                 480 


Asp Asp Arg Glu Ala Thr Tyr Met Leu Lys Ala Ser Ser Gln Ser Glu 
                485                 490                 495     


Met Lys Arg Trp Met Thr Ser Leu Ala Pro Asn Arg Arg Thr Lys Phe 
            500                 505                 510         


Val Ser Phe Thr Ser Arg Leu Leu Asp Cys Pro Gln Val Gln Cys Val 
        515                 520                 525             


His Pro Tyr Val Ala Gln Gln Pro Asp Glu Leu Thr Leu Glu Leu Ala 
    530                 535                 540                 


Asp Ile Leu Asn Ile Leu Asp Lys Thr Asp Asp Gly Trp Ile Phe Gly 
545                 550                 555                 560 


Glu Arg Leu His Asp Gln Glu Arg Gly Trp Phe Pro Ser Ser Met Thr 
                565                 570                 575     


Glu Glu Ile Leu Asn Pro Lys Ile Arg Ser Gln Asn Leu Lys Glu Cys 
            580                 585                 590         


Phe Arg Val His Lys Met Asp Asp Pro Gln Arg Ser Gln Asn Lys Asp 
        595                 600                 605             


Arg Arg Lys Leu Gly Ser Arg Asn Arg Gln 
    610                 615             


<210>  9351
<211>  710
<212>  PRT
<213>  Homo Sapiens

<400>  9351

Met Glu Thr Arg Glu Ser Glu Asp Leu Glu Lys Thr Arg Arg Lys Ser 
1               5                   10                  15      


Ala Ser Asp Gln Trp Asn Thr Asp Asn Glu Pro Ala Lys Val Lys Pro 
            20                  25                  30          


Glu Leu Leu Pro Glu Lys Glu Glu Thr Ser Gln Ala Asp Gln Asp Ile 
        35                  40                  45              


Gln Asp Lys Glu Pro His Cys His Ile Pro Ile Lys Arg Asn Ser Ile 
    50                  55                  60                  


Phe Asn Arg Ser Ile Arg Arg Lys Ser Lys Ala Lys Ala Arg Asp Asn 
65                  70                  75                  80  


Pro Glu Arg Asn Ala Ser Cys Leu Ala Asp Ser Gln Asp Asn Gly Lys 
                85                  90                  95      


Ser Val Asn Glu Pro Leu Thr Leu Asn Ile Pro Trp Ser Arg Met Pro 
            100                 105                 110         


Pro Cys Arg Thr Ala Met Gln Thr Asp Pro Gly Ala Gln Glu Met Ser 
        115                 120                 125             


Glu Ser Ser Ser Thr Pro Gly Asn Gly Ala Thr Pro Glu Glu Trp Pro 
    130                 135                 140                 


Ala Leu Ala Asp Ser Pro Thr Thr Leu Thr Glu Ala Leu Arg Met Ile 
145                 150                 155                 160 


His Pro Ile Pro Ala Asp Ser Trp Arg Asn Leu Ile Glu Gln Ile Gly 
                165                 170                 175     


Leu Leu Tyr Gln Glu Tyr Arg Asp Lys Ser Thr Leu Gln Glu Ile Glu 
            180                 185                 190         


Thr Arg Arg Gln Gln Asp Ala Glu Ile Glu Asp Asn Thr Asn Gly Ser 
        195                 200                 205             


Pro Ala Ser Glu Asp Thr Pro Glu Glu Glu Glu Glu Glu Glu Glu Glu 
    210                 215                 220                 


Glu Glu Pro Ala Ser Pro Pro Glu Arg Lys Thr Leu Pro Gln Ile Cys 
225                 230                 235                 240 


Leu Leu Ser Asn Pro His Ser Arg Phe Asn Leu Trp Gln Asp Leu Pro 
                245                 250                 255     


Glu Ile Arg Ser Ser Gly Val Leu Glu Ile Leu Gln Pro Glu Glu Ile 
            260                 265                 270         


Lys Leu Gln Glu Ala Met Phe Glu Leu Val Thr Ser Glu Ala Ser Tyr 
        275                 280                 285             


Tyr Lys Ser Leu Asn Leu Leu Val Ser His Phe Met Glu Asn Glu Arg 
    290                 295                 300                 


Ile Arg Lys Ile Leu His Pro Ser Glu Ala His Ile Leu Phe Ser Asn 
305                 310                 315                 320 


Val Leu Asp Val Leu Ala Val Ser Glu Arg Phe Leu Leu Glu Leu Glu 
                325                 330                 335     


His Arg Met Glu Glu Asn Ile Val Ile Ser Asp Val Cys Asp Ile Val 
            340                 345                 350         


Tyr Arg Tyr Ala Ala Asp His Phe Ser Val Tyr Ile Thr Tyr Val Ser 
        355                 360                 365             


Asn Gln Thr Tyr Gln Glu Arg Thr Tyr Lys Gln Leu Leu Gln Glu Lys 
    370                 375                 380                 


Ala Ala Phe Arg Glu Leu Ile Ala Gln Leu Glu Leu Asp Pro Lys Cys 
385                 390                 395                 400 


Arg Gly Leu Pro Phe Ser Ser Phe Leu Ile Leu Pro Phe Gln Arg Ile 
                405                 410                 415     


Thr Arg Leu Lys Leu Leu Val Gln Asn Ile Leu Lys Arg Val Glu Glu 
            420                 425                 430         


Arg Ser Glu Arg Glu Cys Thr Ala Leu Asp Ala His Lys Glu Leu Glu 
        435                 440                 445             


Met Val Val Lys Ala Cys Asn Glu Gly Val Arg Lys Met Ser Arg Thr 
    450                 455                 460                 


Glu Gln Met Ile Ser Ile Gln Lys Lys Met Glu Phe Lys Ile Lys Ser 
465                 470                 475                 480 


Val Pro Ile Ile Ser His Ser Arg Trp Leu Leu Lys Gln Gly Glu Leu 
                485                 490                 495     


Gln Gln Met Ser Gly Pro Lys Thr Ser Arg Thr Leu Arg Thr Lys Lys 
            500                 505                 510         


Leu Phe His Glu Ile Tyr Leu Phe Leu Phe Asn Asp Leu Leu Val Ile 
        515                 520                 525             


Cys Arg Gln Ile Pro Gly Asp Lys Tyr Gln Val Phe Asp Ser Ala Pro 
    530                 535                 540                 


Arg Gly Leu Leu Arg Val Glu Glu Leu Glu Asp Gln Gly Gln Thr Leu 
545                 550                 555                 560 


Ala Asn Val Phe Ile Leu Arg Leu Leu Glu Asn Ala Asp Asp Arg Glu 
                565                 570                 575     


Ala Thr Tyr Met Leu Lys Ala Ser Ser Gln Ser Glu Met Lys Arg Trp 
            580                 585                 590         


Met Thr Ser Leu Ala Pro Asn Arg Arg Thr Lys Phe Val Ser Phe Thr 
        595                 600                 605             


Ser Arg Leu Leu Asp Cys Pro Gln Val Gln Cys Val His Pro Tyr Val 
    610                 615                 620                 


Ala Gln Gln Pro Asp Glu Leu Thr Leu Glu Leu Ala Asp Ile Leu Asn 
625                 630                 635                 640 


Ile Leu Asp Lys Thr Asp Asp Gly Trp Ile Phe Gly Glu Arg Leu His 
                645                 650                 655     


Asp Gln Glu Arg Gly Trp Phe Pro Ser Ser Met Thr Glu Glu Ile Leu 
            660                 665                 670         


Asn Pro Lys Ile Arg Ser Gln Asn Leu Lys Glu Cys Phe Arg Val His 
        675                 680                 685             


Lys Met Asp Asp Pro Gln Arg Ser Gln Asn Lys Asp Arg Arg Lys Leu 
    690                 695                 700                 


Gly Ser Arg Asn Arg Gln 
705                 710 


<210>  9352
<211>  187
<212>  PRT
<213>  Homo Sapiens

<400>  9352

Met Phe Glu Leu Val Thr Ser Glu Ala Ser Tyr Tyr Lys Ser Leu Asn 
1               5                   10                  15      


Leu Leu Val Ser His Phe Met Glu Asn Glu Arg Ile Arg Lys Ile Leu 
            20                  25                  30          


His Pro Ser Glu Ala His Ile Leu Phe Ser Asn Val Leu Asp Val Leu 
        35                  40                  45              


Ala Val Ser Glu Arg Phe Leu Leu Glu Leu Glu His Arg Met Glu Glu 
    50                  55                  60                  


Asn Ile Val Ile Ser Asp Val Cys Asp Ile Val Tyr Arg Tyr Ala Ala 
65                  70                  75                  80  


Asp His Phe Ser Val Tyr Ile Thr Tyr Val Ser Asn Gln Thr Tyr Gln 
                85                  90                  95      


Glu Arg Thr Tyr Lys Gln Leu Leu Gln Glu Lys Ala Ala Phe Arg Glu 
            100                 105                 110         


Leu Ile Ala Gln Leu Glu Leu Asp Pro Lys Cys Arg Gly Leu Pro Phe 
        115                 120                 125             


Ser Ser Phe Leu Ile Leu Pro Phe Gln Arg Ile Thr Arg Leu Lys Leu 
    130                 135                 140                 


Leu Val Gln Asn Ile Leu Lys Arg Val Glu Glu Arg Ser Glu Arg Glu 
145                 150                 155                 160 


Cys Thr Ala Leu Asp Ala His Lys Glu Leu Glu Met Val Val Lys Ala 
                165                 170                 175     


Cys Asn Glu Gly Val Arg Lys Met Ser Arg Thr 
            180                 185         


<210>  9353
<211>  150
<212>  PRT
<213>  Homo Sapiens

<400>  9353

Met Val Val Lys Ala Cys Asn Glu Gly Val Arg Lys Met Ser Arg Thr 
1               5                   10                  15      


Glu Gln Met Ile Ser Ile Gln Lys Lys Met Glu Phe Lys Ile Lys Ser 
            20                  25                  30          


Val Pro Ile Ile Ser His Ser Arg Trp Leu Leu Lys Gln Gly Glu Leu 
        35                  40                  45              


Gln Gln Met Ser Gly Pro Lys Thr Ser Arg Thr Leu Arg Thr Lys Lys 
    50                  55                  60                  


Leu Phe His Glu Ile Tyr Leu Phe Leu Phe Asn Asp Leu Leu Val Ile 
65                  70                  75                  80  


Cys Arg Gln Ile Pro Gly Asp Lys Tyr Gln Val Phe Asp Ser Ala Pro 
                85                  90                  95      


Arg Gly Leu Leu Arg Val Glu Glu Leu Glu Asp Gln Gly Gln Thr Leu 
            100                 105                 110         


Ala Asn Val Phe Ile Leu Arg Leu Leu Glu Asn Ala Asp Asp Arg Glu 
        115                 120                 125             


Ala Thr Tyr Met Leu Lys Ala Ser Ser Gln Ser Glu Met Lys Arg Trp 
    130                 135                 140                 


Met Thr Ser Leu Ala Pro 
145                 150 


<210>  9354
<211>  97
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9354

Xaa Glu Leu Leu Pro Glu Lys Glu Glu Thr Ser Gln Ala Asp Gln Asp 
1               5                   10                  15      


Ile Gln Asp Lys Glu Pro His Cys His Ile Pro Ile Lys Arg Asn Ser 
            20                  25                  30          


Ile Phe Asn Arg Ser Ile Arg Arg Lys Ser Lys Ala Lys Ala Arg Asp 
        35                  40                  45              


Asn Pro Glu Arg Asn Ala Ser Cys Leu Ala Asp Ser Gln Asp Asn Gly 
    50                  55                  60                  


Lys Ser Val Asn Glu Pro Leu Thr Leu Asn Ile Pro Trp Ser Arg Met 
65                  70                  75                  80  


Pro Pro Cys Arg Thr Ala Met Gln Thr Asp Pro Gly Ala Gln Glu Met 
                85                  90                  95      


Arg 
    


<210>  9355
<211>  241
<212>  PRT
<213>  Homo Sapiens

<400>  9355

Met Ser Met Leu Phe Tyr Thr Leu Ile Thr Ala Phe Leu Ile Gly Ile 
1               5                   10                  15      


Gln Ala Glu Pro His Ser Glu Ser Asn Val Pro Ala Gly His Thr Ile 
            20                  25                  30          


Pro Gln Ala His Trp Thr Lys Leu Gln His Ser Leu Asp Thr Ala Leu 
        35                  40                  45              


Arg Arg Ala Arg Ser Ala Pro Ala Ala Ala Ile Ala Ala Arg Val Ala 
    50                  55                  60                  


Gly Gln Thr Arg Asn Ile Thr Val Asp Pro Arg Leu Phe Lys Lys Arg 
65                  70                  75                  80  


Arg Leu Arg Ser Pro Arg Val Leu Phe Ser Thr Gln Pro Pro Arg Glu 
                85                  90                  95      


Ala Ala Asp Thr Gln Asp Leu Asp Phe Glu Val Gly Gly Ala Ala Pro 
            100                 105                 110         


Phe Asn Arg Thr His Arg Ser Lys Arg Ser Ser Ser His Pro Ile Phe 
        115                 120                 125             


His Arg Gly Glu Phe Ser Val Cys Asp Ser Val Ser Val Trp Val Gly 
    130                 135                 140                 


Asp Lys Thr Thr Ala Thr Asp Ile Lys Gly Lys Glu Val Met Val Leu 
145                 150                 155                 160 


Gly Glu Val Asn Ile Asn Asn Ser Val Phe Lys Gln Tyr Phe Phe Glu 
                165                 170                 175     


Thr Lys Cys Arg Asp Pro Asn Pro Val Asp Ser Gly Cys Arg Gly Ile 
            180                 185                 190         


Asp Ser Lys His Trp Asn Ser Tyr Cys Thr Thr Thr His Thr Phe Val 
        195                 200                 205             


Lys Ala Leu Thr Met Asp Gly Lys Gln Ala Ala Trp Arg Phe Ile Arg 
    210                 215                 220                 


Ile Asp Thr Ala Cys Val Cys Val Leu Ser Arg Lys Ala Val Arg Arg 
225                 230                 235                 240 


Ala 
    


<210>  9356
<211>  633
<212>  PRT
<213>  Homo Sapiens

<400>  9356

Ala Ala Leu Gly Ser Ser Ser Gly Ser Ala Ser Pro Ala Val Ala Glu 
1               5                   10                  15      


Leu Cys Gln Asn Thr Pro Glu Thr Phe Leu Glu Ala Ser Lys Leu Leu 
            20                  25                  30          


Leu Thr Tyr Ala Asp Asn Ile Leu Arg Asn Pro Asn Asp Glu Lys Tyr 
        35                  40                  45              


Arg Ser Ile Arg Ile Gly Asn Thr Ala Phe Ser Thr Arg Leu Leu Pro 
    50                  55                  60                  


Val Arg Gly Ala Val Glu Cys Leu Phe Glu Met Gly Phe Glu Glu Gly 
65                  70                  75                  80  


Glu Thr His Leu Ile Phe Pro Lys Lys Ala Ser Val Glu Gln Leu Gln 
                85                  90                  95      


Lys Ile Arg Asp Leu Ile Ala Ile Glu Arg Ser Ser Arg Leu Asp Gly 
            100                 105                 110         


Ser Asn Lys Ser His Lys Val Lys Ser Ser Gln Gln Pro Ala Ala Ser 
        115                 120                 125             


Thr Gln Leu Pro Thr Thr Pro Ser Ser Asn Pro Ser Gly Leu Asn Gln 
    130                 135                 140                 


His Thr Arg Asn Arg Gln Gly Gln Ser Ser Asp Pro Pro Ser Ala Ser 
145                 150                 155                 160 


Thr Val Ala Ala Asp Ser Ala Ile Leu Glu Val Leu Gln Ser Asn Ile 
                165                 170                 175     


Gln His Val Leu Val Tyr Glu Asn Pro Ala Leu Gln Glu Lys Ala Leu 
            180                 185                 190         


Ala Cys Ile Pro Val Gln Glu Leu Lys Arg Lys Ser Gln Glu Lys Leu 
        195                 200                 205             


Ser Arg Ala Arg Lys Leu Asp Lys Gly Ile Asn Ile Ser Asp Glu Asp 
    210                 215                 220                 


Phe Leu Leu Leu Glu Leu Leu His Trp Phe Lys Glu Glu Phe Phe His 
225                 230                 235                 240 


Trp Val Asn Asn Val Leu Cys Ser Lys Cys Gly Gly Gln Thr Arg Ser 
                245                 250                 255     


Arg Asp Arg Ser Leu Leu Pro Ser Asp Asp Glu Leu Lys Trp Gly Ala 
            260                 265                 270         


Lys Glu Val Glu Asp His Tyr Cys Asp Ala Cys Gln Phe Ser Asn Arg 
        275                 280                 285             


Phe Pro Arg Tyr Asn Asn Pro Glu Lys Leu Leu Glu Thr Arg Cys Gly 
    290                 295                 300                 


Arg Cys Gly Glu Trp Ala Asn Cys Phe Thr Leu Cys Cys Arg Ala Val 
305                 310                 315                 320 


Gly Phe Glu Ala Arg Tyr Val Trp Asp Tyr Thr Glu Leu Gln Arg Thr 
                325                 330                 335     


Leu Ser Leu Lys Leu Thr Thr Leu Lys Glu Ile Gly Lys Thr Phe Leu 
            340                 345                 350         


Arg Ile Ser Lys Arg Gln Lys Leu Ile Gln Val Val Asp Val Thr Trp 
        355                 360                 365             


Arg Tyr Ser Cys Lys His Glu Glu Val Ile Ala Arg Arg Thr Lys Val 
    370                 375                 380                 


Lys Glu Ala Leu Leu Arg Asp Thr Ile Asn Gly Leu Asn Lys Gln Arg 
385                 390                 395                 400 


Gln Leu Phe Leu Ser Glu Asn Arg Arg Lys Glu Leu Leu Gln Arg Ile 
                405                 410                 415     


Ile Val Glu Leu Val Glu Phe Ile Ser Pro Lys Thr Pro Lys Pro Gly 
            420                 425                 430         


Glu Leu Gly Gly Arg Ile Ser Gly Ser Val Ala Trp Arg Val Ala Arg 
        435                 440                 445             


Gly Glu Met Gly Leu Gln Arg Lys Glu Thr Leu Phe Ile Pro Cys Glu 
    450                 455                 460                 


Asn Glu Lys Ile Ser Lys Gln Leu His Leu Cys Tyr Asn Ile Val Lys 
465                 470                 475                 480 


Asp Arg Tyr Val Arg Val Ser Asn Asn Asn Gln Thr Ile Ser Gly Trp 
                485                 490                 495     


Glu Asn Gly Val Trp Lys Met Glu Ser Ile Phe Arg Lys Val Glu Thr 
            500                 505                 510         


Asp Trp His Met Val Tyr Leu Ala Arg Lys Glu Gly Ser Ser Phe Ala 
        515                 520                 525             


Tyr Ile Ser Trp Lys Phe Glu Cys Gly Ser Val Gly Leu Lys Val Asp 
    530                 535                 540                 


Ser Ile Ser Ile Arg Thr Ser Ser Gln Thr Phe Gln Thr Gly Thr Val 
545                 550                 555                 560 


Glu Trp Lys Leu Arg Ser Asp Thr Ala Gln Val Glu Leu Thr Gly Asp 
                565                 570                 575     


Asn Ser Leu His Ser Tyr Ala Asp Phe Ser Gly Ala Thr Glu Val Ile 
            580                 585                 590         


Leu Glu Ala Glu Leu Ser Arg Gly Asp Gly Asp Val Ala Trp Gln His 
        595                 600                 605             


Thr Gln Leu Phe Arg Gln Ser Leu Asn Asp His Glu Glu Asn Cys Leu 
    610                 615                 620                 


Glu Ile Ile Ile Lys Phe Ser Asp Leu 
625                 630             


<210>  9357
<211>  654
<212>  PRT
<213>  Homo Sapiens

<400>  9357

Met Ala Ala Ala Ala Leu Gly Ser Ser Ser Gly Ser Ala Ser Pro Ala 
1               5                   10                  15      


Val Ala Glu Leu Cys Gln Asn Thr Pro Glu Thr Phe Leu Glu Ala Ser 
            20                  25                  30          


Lys Leu Leu Leu Thr Tyr Ala Asp Asn Ile Leu Arg Asn Pro Asn Asp 
        35                  40                  45              


Glu Lys Tyr Arg Ser Ile Arg Ile Gly Asn Thr Ala Phe Ser Thr Arg 
    50                  55                  60                  


Leu Leu Pro Val Arg Gly Ala Val Glu Cys Leu Phe Glu Met Gly Phe 
65                  70                  75                  80  


Glu Glu Gly Glu Thr His Leu Ile Phe Pro Lys Lys Ala Ser Val Glu 
                85                  90                  95      


Gln Leu Gln Lys Ile Arg Asp Leu Ile Ala Ile Glu Arg Ser Ser Arg 
            100                 105                 110         


Leu Asp Gly Ser Asn Lys Ser His Lys Val Lys Ser Ser Gln Gln Pro 
        115                 120                 125             


Ala Ala Ser Thr Gln Leu Pro Thr Thr Pro Ser Ser Asn Pro Ser Gly 
    130                 135                 140                 


Leu Asn Gln His Thr Arg Asn Arg Gln Gly Gln Ser Ser Asp Pro Pro 
145                 150                 155                 160 


Ser Ala Ser Thr Val Ala Ala Asp Ser Ala Ile Leu Glu Val Leu Gln 
                165                 170                 175     


Ser Asn Ile Gln His Val Leu Val Tyr Glu Asn Pro Ala Leu Gln Glu 
            180                 185                 190         


Lys Ala Leu Ala Cys Ile Pro Val Gln Glu Leu Lys Arg Lys Ser Gln 
        195                 200                 205             


Glu Lys Leu Ser Arg Ala Arg Lys Leu Asp Lys Gly Ile Asn Ile Ser 
    210                 215                 220                 


Asp Glu Asp Phe Leu Leu Leu Glu Leu Leu His Trp Phe Lys Glu Glu 
225                 230                 235                 240 


Phe Phe His Trp Val Asn Asn Val Leu Cys Ser Lys Cys Gly Gly Gln 
                245                 250                 255     


Thr Arg Ser Arg Asp Arg Ser Leu Leu Pro Ser Asp Asp Glu Leu Lys 
            260                 265                 270         


Trp Gly Ala Lys Glu Val Glu Asp His Tyr Cys Asp Ala Cys Gln Phe 
        275                 280                 285             


Ser Asn Arg Phe Pro Arg Tyr Asn Asn Pro Glu Lys Leu Leu Glu Thr 
    290                 295                 300                 


Arg Cys Gly Arg Cys Gly Glu Trp Ala Asn Cys Phe Thr Leu Cys Cys 
305                 310                 315                 320 


Arg Ala Val Gly Phe Glu Ala Arg Tyr Val Trp Asp Tyr Thr Asp His 
                325                 330                 335     


Val Trp Thr Glu Val Tyr Ser Pro Ser Gln Gln Arg Trp Leu His Cys 
            340                 345                 350         


Asp Ala Cys Glu Asp Val Cys Asp Lys Pro Leu Leu Tyr Glu Ile Gly 
        355                 360                 365             


Trp Gly Lys Lys Leu Ser Tyr Val Ile Ala Phe Ser Lys Asp Glu Val 
    370                 375                 380                 


Val Asp Val Thr Trp Arg Tyr Ser Cys Lys His Glu Glu Val Ile Ala 
385                 390                 395                 400 


Arg Arg Thr Lys Val Lys Glu Ala Leu Leu Arg Asp Thr Ile Asn Gly 
                405                 410                 415     


Leu Asn Lys Gln Arg Gln Leu Phe Leu Ser Glu Asn Arg Arg Lys Glu 
            420                 425                 430         


Leu Leu Gln Arg Ile Ile Val Glu Leu Val Glu Phe Ile Ser Pro Lys 
        435                 440                 445             


Thr Pro Lys Pro Gly Glu Leu Gly Gly Arg Ile Ser Gly Ser Val Ala 
    450                 455                 460                 


Trp Arg Val Ala Arg Gly Glu Met Gly Leu Gln Arg Lys Glu Thr Leu 
465                 470                 475                 480 


Phe Ile Pro Cys Glu Asn Glu Lys Ile Ser Lys Gln Leu His Leu Cys 
                485                 490                 495     


Tyr Asn Ile Val Lys Asp Arg Tyr Val Arg Val Ser Asn Asn Asn Gln 
            500                 505                 510         


Thr Ile Ser Gly Trp Glu Asn Gly Val Trp Lys Met Glu Ser Ile Phe 
        515                 520                 525             


Arg Lys Val Glu Thr Asp Trp His Met Val Tyr Leu Ala Arg Lys Glu 
    530                 535                 540                 


Gly Ser Ser Phe Ala Tyr Ile Ser Trp Lys Phe Glu Cys Gly Ser Val 
545                 550                 555                 560 


Gly Leu Lys Val Asp Ser Ile Ser Ile Arg Thr Ser Ser Gln Thr Phe 
                565                 570                 575     


Gln Thr Gly Thr Val Glu Trp Lys Leu Arg Ser Asp Thr Ala Gln Val 
            580                 585                 590         


Glu Leu Thr Gly Asp Asn Ser Leu His Ser Tyr Ala Asp Phe Ser Gly 
        595                 600                 605             


Ala Thr Glu Val Ile Leu Glu Ala Glu Leu Ser Arg Gly Asp Gly Asp 
    610                 615                 620                 


Val Ala Trp Gln His Thr Gln Leu Phe Arg Gln Ser Leu Asn Asp His 
625                 630                 635                 640 


Glu Glu Asn Cys Leu Glu Ile Ile Ile Lys Phe Ser Asp Leu 
                645                 650                 


<210>  9358
<211>  558
<212>  PRT
<213>  Homo Sapiens

<400>  9358

Met Ala Ala Ala Ala Leu Gly Ser Ser Ser Gly Ser Ala Ser Pro Ala 
1               5                   10                  15      


Val Ala Glu Leu Cys Gln Asn Thr Pro Glu Thr Phe Leu Glu Ala Ser 
            20                  25                  30          


Lys Leu Leu Leu Thr Tyr Ala Asp Asn Ile Leu Arg Asn Pro Asn Asp 
        35                  40                  45              


Glu Lys Tyr Arg Ser Ile Arg Ile Gly Asn Thr Ala Phe Ser Thr Arg 
    50                  55                  60                  


Leu Leu Pro Val Arg Gly Ala Val Glu Cys Leu Phe Glu Met Gly Phe 
65                  70                  75                  80  


Glu Glu Gly Glu Thr His Leu Ile Phe Pro Lys Lys Ala Ser Val Glu 
                85                  90                  95      


Gln Leu Gln Lys Ile Arg Asp Leu Ile Ala Ile Glu Arg Ser Ser Arg 
            100                 105                 110         


Leu Asp Gly Ser Asn Lys Ser His Lys Val Lys Ser Ser Gln Gln Pro 
        115                 120                 125             


Ala Ala Ser Thr Gln Leu Pro Thr Thr Pro Ser Ser Asn Pro Ser Gly 
    130                 135                 140                 


Leu Asn Gln His Thr Arg Asn Arg Gln Gly Gln Ser Ser Asp Pro Pro 
145                 150                 155                 160 


Ser Ala Ser Thr Val Ala Ala Asp Ser Ala Ile Leu Glu Val Leu Gln 
                165                 170                 175     


Ser Asn Ile Gln His Val Leu Val Tyr Glu Asn Pro Ala Leu Gln Glu 
            180                 185                 190         


Lys Ala Leu Ala Cys Ile Pro Val Gln Glu Leu Lys Arg Lys Ser Gln 
        195                 200                 205             


Glu Lys Leu Ser Arg Ala Arg Lys Leu Asp Lys Gly Ile Asn Ile Ser 
    210                 215                 220                 


Asp Glu Asp Phe Leu Leu Leu Glu Leu Leu His Trp Phe Lys Glu Glu 
225                 230                 235                 240 


Phe Phe His Trp Val Asn Asn Val Leu Cys Ser Lys Cys Gly Gly Gln 
                245                 250                 255     


Thr Arg Ser Arg Asp Arg Ser Leu Leu Pro Ser Asp Asp Glu Leu Lys 
            260                 265                 270         


Trp Gly Ala Lys Glu Val Glu Asp His Tyr Cys Asp Ala Cys Gln Phe 
        275                 280                 285             


Ser Asn Arg Phe Pro Arg Tyr Asn Asn Pro Glu Lys Leu Leu Glu Thr 
    290                 295                 300                 


Arg Cys Gly Arg Cys Gly Glu Trp Ala Asn Cys Phe Thr Leu Cys Cys 
305                 310                 315                 320 


Arg Ala Val Gly Phe Glu Ala Arg Tyr Val Trp Asp Tyr Thr Asp His 
                325                 330                 335     


Val Trp Thr Glu Val Tyr Ser Pro Ser Gln Gln Arg Trp Leu His Cys 
            340                 345                 350         


Asp Ala Cys Glu Asp Val Cys Asp Lys Pro Leu Leu Tyr Glu Ile Gly 
        355                 360                 365             


Trp Gly Lys Lys Leu Ser Tyr Val Ile Ala Phe Ser Lys Asp Glu Val 
    370                 375                 380                 


Val Asp Val Thr Trp Arg Tyr Ser Cys Lys His Glu Glu Val Ile Ala 
385                 390                 395                 400 


Arg Arg Thr Lys Val Lys Glu Ala Leu Leu Arg Asp Thr Ile Asn Gly 
                405                 410                 415     


Leu Asn Lys Gln Arg Gln Leu Phe Leu Ser Glu Asn Arg Arg Lys Glu 
            420                 425                 430         


Leu Leu Gln Arg Ile Ile Val Glu Leu Val Glu Phe Ile Ser Pro Lys 
        435                 440                 445             


Thr Pro Lys Pro Gly Glu Leu Gly Gly Arg Ile Ser Gly Ser Val Ala 
    450                 455                 460                 


Trp Arg Val Ala Arg Gly Glu Met Gly Leu Gln Arg Lys Glu Thr Leu 
465                 470                 475                 480 


Phe Ile Pro Cys Glu Asn Glu Lys Ile Ser Lys Gln Leu His Leu Cys 
                485                 490                 495     


Tyr Asn Ile Val Lys Asp Arg Tyr Val Arg Val Ser Asn Asn Asn Gln 
            500                 505                 510         


Thr Ile Ser Gly Trp Glu Asn Gly Val Trp Lys Met Glu Ser Ile Phe 
        515                 520                 525             


Arg Lys Val Glu Thr Asp Trp His Met Ile Thr Val Phe Thr Pro Met 
    530                 535                 540                 


Leu Ile Phe Leu Val Pro Leu Lys Leu Phe Trp Lys Gln Asn 
545                 550                 555             


<210>  9359
<211>  636
<212>  PRT
<213>  Homo Sapiens

<400>  9359

Met Ala Ala Ala Ala Leu Gly Ser Ser Ser Gly Ser Ala Ser Pro Ala 
1               5                   10                  15      


Val Ala Glu Leu Cys Gln Asn Thr Pro Glu Thr Phe Leu Glu Ala Ser 
            20                  25                  30          


Lys Leu Leu Leu Thr Tyr Ala Asp Asn Ile Leu Arg Asn Pro Asn Asp 
        35                  40                  45              


Glu Lys Tyr Arg Ser Ile Arg Ile Gly Asn Thr Ala Phe Ser Thr Arg 
    50                  55                  60                  


Leu Leu Pro Val Arg Gly Ala Val Glu Cys Leu Phe Glu Met Gly Phe 
65                  70                  75                  80  


Glu Glu Gly Glu Thr His Leu Ile Phe Pro Lys Lys Ala Ser Val Glu 
                85                  90                  95      


Gln Leu Gln Lys Ile Arg Asp Leu Ile Ala Ile Glu Arg Ser Ser Arg 
            100                 105                 110         


Leu Asp Gly Ser Asn Lys Ser His Lys Val Lys Ser Ser Gln Gln Pro 
        115                 120                 125             


Ala Ala Ser Thr Gln Leu Pro Thr Thr Pro Ser Ser Asn Pro Ser Gly 
    130                 135                 140                 


Leu Asn Gln His Thr Arg Asn Arg Gln Gly Gln Ser Ser Asp Pro Pro 
145                 150                 155                 160 


Ser Ala Ser Thr Val Ala Ala Asp Ser Ala Ile Leu Glu Val Leu Gln 
                165                 170                 175     


Ser Asn Ile Gln His Val Leu Val Tyr Glu Asn Pro Ala Leu Gln Glu 
            180                 185                 190         


Lys Ala Leu Ala Cys Ile Pro Val Gln Glu Leu Lys Arg Lys Ser Gln 
        195                 200                 205             


Glu Lys Leu Ser Arg Ala Arg Lys Leu Asp Lys Gly Ile Asn Ile Ser 
    210                 215                 220                 


Asp Glu Asp Phe Leu Leu Leu Glu Leu Leu His Trp Phe Lys Glu Glu 
225                 230                 235                 240 


Phe Phe His Trp Val Asn Asn Val Leu Cys Ser Lys Cys Gly Gly Gln 
                245                 250                 255     


Thr Arg Ser Arg Asp Arg Ser Leu Leu Pro Ser Asp Asp Glu Leu Lys 
            260                 265                 270         


Trp Gly Ala Lys Glu Val Glu Asp His Tyr Cys Asp Ala Cys Gln Phe 
        275                 280                 285             


Ser Asn Arg Phe Pro Arg Tyr Asn Asn Pro Glu Lys Leu Leu Glu Thr 
    290                 295                 300                 


Arg Cys Gly Arg Cys Gly Glu Trp Ala Asn Cys Phe Thr Leu Cys Cys 
305                 310                 315                 320 


Arg Ala Val Gly Phe Glu Ala Arg Tyr Val Trp Asp Tyr Thr Glu Leu 
                325                 330                 335     


Gln Arg Thr Leu Ser Leu Lys Leu Thr Thr Leu Lys Glu Ile Gly Lys 
            340                 345                 350         


Thr Phe Leu Arg Ile Ser Lys Arg Gln Lys Leu Ile Gln Val Val Asp 
        355                 360                 365             


Val Thr Trp Arg Tyr Ser Cys Lys His Glu Glu Val Ile Ala Arg Arg 
    370                 375                 380                 


Thr Lys Val Lys Glu Ala Leu Leu Arg Asp Thr Ile Asn Gly Leu Asn 
385                 390                 395                 400 


Lys Gln Arg Gln Leu Phe Leu Ser Glu Asn Arg Arg Lys Glu Leu Leu 
                405                 410                 415     


Gln Arg Ile Ile Val Glu Leu Val Glu Phe Ile Ser Pro Lys Thr Pro 
            420                 425                 430         


Lys Pro Gly Glu Leu Gly Gly Arg Ile Ser Gly Ser Val Ala Trp Arg 
        435                 440                 445             


Val Ala Arg Gly Glu Met Gly Leu Gln Arg Lys Glu Thr Leu Phe Ile 
    450                 455                 460                 


Pro Cys Glu Asn Glu Lys Ile Ser Lys Gln Leu His Leu Cys Tyr Asn 
465                 470                 475                 480 


Ile Val Lys Asp Arg Tyr Val Arg Val Ser Asn Asn Asn Gln Thr Ile 
                485                 490                 495     


Ser Gly Trp Glu Asn Gly Val Trp Lys Met Glu Ser Ile Phe Arg Lys 
            500                 505                 510         


Val Glu Thr Asp Trp His Met Val Tyr Leu Ala Arg Lys Glu Gly Ser 
        515                 520                 525             


Ser Phe Ala Tyr Ile Ser Trp Lys Phe Glu Cys Gly Ser Val Gly Leu 
    530                 535                 540                 


Lys Val Asp Ser Ile Ser Ile Arg Thr Ser Ser Gln Thr Phe Gln Thr 
545                 550                 555                 560 


Gly Thr Val Glu Trp Lys Leu Arg Ser Asp Thr Ala Gln Val Glu Leu 
                565                 570                 575     


Thr Gly Asp Asn Ser Leu His Ser Tyr Ala Asp Phe Ser Gly Ala Thr 
            580                 585                 590         


Glu Val Ile Leu Glu Ala Glu Leu Ser Arg Gly Asp Gly Asp Val Ala 
        595                 600                 605             


Trp Gln His Thr Gln Leu Phe Arg Gln Ser Leu Asn Asp His Glu Glu 
    610                 615                 620                 


Asn Cys Leu Glu Ile Ile Ile Lys Phe Ser Asp Leu 
625                 630                 635     


<210>  9360
<211>  114
<212>  PRT
<213>  Homo Sapiens

<400>  9360

Met Gly Phe Glu Glu Gly Glu Thr His Leu Ile Phe Pro Lys Lys Ala 
1               5                   10                  15      


Ser Val Glu Gln Leu Gln Lys Ile Arg Asp Leu Ile Ala Ile Glu Arg 
            20                  25                  30          


Ser Ser Arg Leu Asp Gly Ser Asn Lys Ser His Lys Val Lys Ser Ser 
        35                  40                  45              


Gln Gln Pro Ala Ala Ser Thr Gln Leu Pro Thr Thr Pro Ser Ser Asn 
    50                  55                  60                  


Pro Ser Gly Leu Asn Gln His Thr Arg Asn Arg Gln Gly Gln Ser Ser 
65                  70                  75                  80  


Asp Pro Pro Ser Ala Ser Thr Val Ala Ala Asp Ser Ala Ile Leu Glu 
                85                  90                  95      


Val Leu Gln Ser Asn Ile Gln His Val Leu Val Tyr Glu Asn Pro Ala 
            100                 105                 110         


Leu Gln 
        


<210>  9361
<211>  612
<212>  PRT
<213>  Homo Sapiens

<400>  9361

Met Arg Asn Pro Asn Asp Glu Lys Tyr Arg Ser Ile Arg Ile Gly Asn 
1               5                   10                  15      


Thr Ala Phe Ser Thr Arg Leu Leu Pro Val Arg Gly Ala Val Glu Cys 
            20                  25                  30          


Leu Phe Glu Met Gly Phe Glu Glu Gly Glu Thr His Leu Ile Phe Pro 
        35                  40                  45              


Lys Lys Ala Ser Val Glu Gln Leu Gln Lys Ile Arg Asp Leu Ile Ala 
    50                  55                  60                  


Ile Glu Arg Ser Ser Arg Leu Asp Gly Ser Asn Lys Ser His Lys Val 
65                  70                  75                  80  


Lys Ser Ser Gln Gln Pro Ala Ala Ser Thr Gln Leu Pro Thr Thr Pro 
                85                  90                  95      


Ser Ser Asn Pro Ser Gly Leu Asn Gln His Thr Arg Asn Arg Gln Gly 
            100                 105                 110         


Gln Ser Ser Asp Pro Pro Ser Ala Ser Thr Val Ala Ala Asp Ser Ala 
        115                 120                 125             


Ile Leu Glu Val Leu Gln Ser Asn Ile Gln His Val Leu Val Tyr Glu 
    130                 135                 140                 


Asn Pro Ala Leu Gln Glu Lys Ala Leu Ala Cys Ile Pro Val Gln Glu 
145                 150                 155                 160 


Leu Lys Arg Lys Ser Gln Glu Lys Leu Ser Arg Ala Arg Lys Leu Asp 
                165                 170                 175     


Lys Gly Ile Asn Ile Ser Asp Glu Asp Phe Leu Leu Leu Glu Leu Leu 
            180                 185                 190         


His Trp Phe Lys Glu Glu Phe Phe His Trp Val Asn Asn Val Leu Cys 
        195                 200                 205             


Ser Lys Cys Gly Gly Gln Thr Arg Ser Arg Asp Arg Ser Leu Leu Pro 
    210                 215                 220                 


Ser Asp Asp Glu Leu Lys Trp Gly Ala Lys Glu Val Glu Asp His Tyr 
225                 230                 235                 240 


Cys Asp Ala Cys Gln Phe Ser Asn Arg Phe Pro Arg Tyr Asn Asn Pro 
                245                 250                 255     


Glu Lys Leu Leu Glu Thr Arg Cys Gly Arg Cys Gly Glu Trp Ala Asn 
            260                 265                 270         


Cys Phe Thr Leu Cys Cys Arg Ala Val Gly Phe Glu Ala Arg Tyr Val 
        275                 280                 285             


Trp Asp Tyr Thr Asp His Val Trp Thr Glu Val Tyr Ser Pro Ser Gln 
    290                 295                 300                 


Gln Arg Trp Leu His Cys Asp Ala Cys Glu Asp Val Cys Asp Lys Pro 
305                 310                 315                 320 


Leu Leu Tyr Glu Ile Gly Trp Gly Lys Lys Leu Ser Tyr Val Ile Ala 
                325                 330                 335     


Phe Ser Lys Asp Glu Val Val Asp Val Thr Trp Arg Tyr Ser Cys Lys 
            340                 345                 350         


His Glu Glu Val Ile Ala Arg Arg Thr Lys Val Lys Glu Ala Leu Leu 
        355                 360                 365             


Arg Asp Thr Ile Asn Gly Leu Asn Lys Gln Arg Gln Leu Phe Leu Ser 
    370                 375                 380                 


Glu Asn Arg Arg Lys Glu Leu Leu Gln Arg Ile Ile Val Glu Leu Val 
385                 390                 395                 400 


Glu Phe Ile Ser Pro Lys Thr Pro Lys Pro Gly Glu Leu Gly Gly Arg 
                405                 410                 415     


Ile Ser Gly Ser Val Ala Trp Arg Val Ala Arg Gly Glu Met Gly Leu 
            420                 425                 430         


Gln Arg Lys Glu Thr Leu Phe Ile Pro Cys Glu Asn Glu Lys Ile Ser 
        435                 440                 445             


Lys Gln Leu His Leu Cys Tyr Asn Ile Val Lys Asp Arg Tyr Val Arg 
    450                 455                 460                 


Val Ser Asn Asn Asn Gln Thr Ile Ser Gly Trp Glu Asn Gly Val Trp 
465                 470                 475                 480 


Lys Met Glu Ser Ile Phe Arg Lys Val Glu Thr Asp Trp His Met Val 
                485                 490                 495     


Tyr Leu Ala Arg Lys Glu Gly Ser Ser Phe Ala Tyr Ile Ser Trp Lys 
            500                 505                 510         


Phe Glu Cys Gly Ser Val Gly Leu Lys Val Asp Ser Ile Ser Ile Arg 
        515                 520                 525             


Thr Ser Ser Gln Thr Phe Gln Thr Gly Thr Val Glu Trp Lys Leu Arg 
    530                 535                 540                 


Ser Asp Thr Ala Gln Val Glu Leu Thr Gly Asp Asn Ser Leu His Ser 
545                 550                 555                 560 


Tyr Ala Asp Phe Ser Gly Ala Thr Glu Val Ile Leu Glu Ala Glu Leu 
                565                 570                 575     


Ser Arg Gly Asp Gly Asp Val Ala Trp Gln His Thr Gln Leu Phe Arg 
            580                 585                 590         


Gln Ser Leu Asn Asp His Glu Glu Asn Cys Leu Glu Ile Ile Ile Lys 
        595                 600                 605             


Phe Ser Asp Leu 
    610         


<210>  9362
<211>  240
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9362

Xaa Ser Gly Ser Ala Ser Pro Ala Val Ala Glu Leu Cys Gln Asn Thr 
1               5                   10                  15      


Pro Glu Thr Phe Leu Glu Ala Ser Lys Leu Leu Leu Thr Tyr Ala Asp 
            20                  25                  30          


Asn Ile Leu Arg Asn Pro Asn Asp Glu Lys Tyr Arg Ser Ile Arg Ile 
        35                  40                  45              


Gly Asn Thr Ala Phe Ser Thr Arg Leu Leu Pro Val Arg Gly Ala Val 
    50                  55                  60                  


Glu Cys Leu Phe Glu Met Gly Phe Glu Glu Gly Glu Thr His Leu Ile 
65                  70                  75                  80  


Phe Pro Lys Lys Ala Ser Val Glu Gln Leu Gln Lys Ile Arg Asp Leu 
                85                  90                  95      


Ile Ala Ile Glu Arg Ser Ser Arg Leu Asp Gly Ser Asn Lys Ser His 
            100                 105                 110         


Lys Val Lys Ser Ser Gln Gln Pro Ala Ala Ser Thr Gln Leu Pro Thr 
        115                 120                 125             


Thr Pro Ser Ser Asn Pro Ser Gly Leu Asn Gln His Thr Arg Asn Arg 
    130                 135                 140                 


Gln Gly Gln Ser Ser Asp Pro Pro Ser Ala Ser Thr Val Ala Ala Asp 
145                 150                 155                 160 


Ser Ala Ile Leu Glu Val Leu Gln Ser Asn Ile Gln His Val Leu Val 
                165                 170                 175     


Tyr Glu Asn Pro Ala Leu Gln Glu Lys Ala Leu Ala Cys Ile Pro Val 
            180                 185                 190         


Gln Glu Leu Lys Arg Lys Ser Gln Glu Lys Leu Ser Arg Ala Arg Lys 
        195                 200                 205             


Leu Asp Lys Asp Ile Ile Thr Leu Arg Asn Phe Trp Lys Gln Asp Val 
    210                 215                 220                 


Asp Gly Val Ala Ser Gly Pro Ile Val Leu His Cys Ala Ala Glu Leu 
225                 230                 235                 240 


<210>  9363
<211>  23
<212>  PRT
<213>  Homo Sapiens

<400>  9363

Glu Ala Pro Gly Ala Pro Pro Arg Thr Leu Thr Trp Glu Ala Met Glu 
1               5                   10                  15      


Gln Ile Arg Tyr Leu Ser Ser 
            20              


<210>  9364
<211>  291
<212>  PRT
<213>  Homo Sapiens

<400>  9364

Met Ala Val Thr Leu Ser Leu Leu Leu Gly Gly Arg Val Cys Ala Ala 
1               5                   10                  15      


Val Thr Arg Cys Gly Phe Ala Thr Arg Gly Val Ala Gly Pro Gly Pro 
            20                  25                  30          


Ile Gly Arg Glu Pro Asp Pro Asp Ser Asp Trp Glu Pro Glu Glu Arg 
        35                  40                  45              


Glu Leu Gln Glu Val Glu Ser Thr Leu Lys Arg Gln Lys Gln Ala Ile 
    50                  55                  60                  


Arg Phe Gln Lys Ile Arg Arg Gln Met Glu Ala Pro Gly Ala Pro Pro 
65                  70                  75                  80  


Arg Thr Leu Thr Trp Glu Ala Met Glu Gln Ile Arg Tyr Leu His Glu 
                85                  90                  95      


Glu Phe Pro Glu Ser Trp Ser Val Pro Arg Leu Ala Glu Gly Phe Asp 
            100                 105                 110         


Val Ser Thr Asp Val Ile Arg Arg Val Leu Lys Ser Lys Phe Leu Pro 
        115                 120                 125             


Thr Leu Glu Gln Lys Leu Lys Gln Asp Gln Lys Val Leu Lys Lys Ala 
    130                 135                 140                 


Gly Leu Ala His Ser Leu Gln His Leu Arg Gly Ser Gly Asn Thr Ser 
145                 150                 155                 160 


Lys Leu Leu Pro Ala Gly His Ser Val Ser Gly Ser Leu Leu Met Pro 
                165                 170                 175     


Gly His Glu Ala Ser Ser Lys Asp Pro Asn His Ser Thr Ala Leu Lys 
            180                 185                 190         


Val Ile Glu Ser Asp Thr His Arg Thr Asn Thr Pro Arg Arg Arg Lys 
        195                 200                 205             


Gly Arg Asn Lys Glu Ile Gln Asp Leu Glu Glu Ser Phe Val Pro Val 
    210                 215                 220                 


Ala Ala Pro Leu Gly His Pro Arg Glu Leu Gln Lys Tyr Ser Ser Asp 
225                 230                 235                 240 


Ser Glu Ser Pro Arg Gly Thr Gly Ser Gly Ala Leu Pro Ser Gly Gln 
                245                 250                 255     


Lys Leu Glu Glu Leu Lys Ala Glu Glu Pro Asp Asn Phe Ser Ser Lys 
            260                 265                 270         


Val Val Gln Arg Gly Arg Glu Phe Phe Asp Ser Asn Gly Asn Phe Leu 
        275                 280                 285             


Tyr Arg Ile 
    290     


<210>  9365
<211>  280
<212>  PRT
<213>  Homo Sapiens

<400>  9365

Met Ala Arg Phe Trp Val Cys Val Ala Gly Ala Gly Phe Phe Leu Ala 
1               5                   10                  15      


Phe Leu Val Leu His Ser Arg Phe Cys Gly Ser Pro Val Leu Arg Asn 
            20                  25                  30          


Phe Thr Phe Ala Val Ser Trp Arg Thr Glu Lys Ile Leu Tyr Arg Leu 
        35                  40                  45              


Asp Val Gly Trp Pro Lys His Pro Glu Tyr Phe Thr Gly Thr Thr Phe 
    50                  55                  60                  


Cys Val Ala Val Asp Ser Leu Asn Gly Leu Val Tyr Ile Gly Gln Arg 
65                  70                  75                  80  


Gly Asp Asn Ile Pro Lys Ile Leu Val Phe Thr Glu Asp Gly Tyr Phe 
                85                  90                  95      


Leu Arg Ala Trp Asn Tyr Thr Val Asp Thr Pro His Gly Ile Phe Ala 
            100                 105                 110         


Ala Ser Thr Leu Tyr Glu Gln Ser Val Trp Ile Thr Asp Val Gly Ser 
        115                 120                 125             


Asp Phe Met Ile Leu Trp Leu His Gly Glu Asn Gly Thr Gly Pro Ala 
    130                 135                 140                 


Lys Phe Asn Ile Pro His Ser Val Thr Leu Asp Ser Ala Gly Arg Val 
145                 150                 155                 160 


Trp Val Ala Asp Arg Gly Asn Lys Arg Ile Gln Val Phe Asp Lys Asp 
                165                 170                 175     


Thr Gly Glu Trp Leu Gly Ala Trp Asn Asn Cys Phe Thr Glu Glu Gly 
            180                 185                 190         


Pro Ser Ser Val Arg Phe Thr Pro Asp Gly Lys Tyr Leu Ile Val Ala 
        195                 200                 205             


Gln Leu Asn Leu Ser Arg Leu Ser Val Val Ala Ala Pro Pro Val Gly 
    210                 215                 220                 


Ser Ile Gly Glu Cys Ser Val Ile Ser Thr Ile Gln Leu Ala Asp Gln 
225                 230                 235                 240 


Val Leu Pro His Leu Leu Glu Val Asp Arg Lys Thr Gly Ala Val Tyr 
                245                 250                 255     


Val Ala Glu Ile Gly Ala Lys Gln Val Gln Lys Tyr Val Pro Leu Asn 
            260                 265                 270         


Ser Tyr Val Pro Ser Phe Gly Ser 
        275                 280 


<210>  9366
<211>  347
<212>  PRT
<213>  Homo Sapiens

<400>  9366

Met Ala Arg Phe Trp Val Cys Val Ala Gly Ala Gly Phe Phe Leu Ala 
1               5                   10                  15      


Phe Leu Val Leu His Ser Arg Phe Cys Gly Ser Pro Val Leu Arg Asn 
            20                  25                  30          


Phe Thr Phe Ala Val Ser Trp Arg Thr Glu Lys Ile Leu Tyr Arg Leu 
        35                  40                  45              


Asp Val Gly Trp Pro Lys His Pro Glu Tyr Phe Thr Gly Thr Thr Phe 
    50                  55                  60                  


Cys Val Ala Val Asp Ser Leu Asn Gly Leu Val Tyr Ile Gly Gln Arg 
65                  70                  75                  80  


Gly Asp Asn Ile Pro Lys Ile Leu Val Phe Thr Glu Asp Gly Tyr Phe 
                85                  90                  95      


Leu Arg Ala Trp Asn Tyr Thr Val Asp Thr Pro His Gly Ile Phe Ala 
            100                 105                 110         


Ala Ser Thr Leu Tyr Glu Gln Ser Val Trp Ile Thr Asp Val Gly Ser 
        115                 120                 125             


Gly Phe Phe Gly His Thr Val Lys Lys Tyr Ser Ser Phe Gly Asp Leu 
    130                 135                 140                 


Val Gln Val Leu Gly Thr Pro Gly Lys Lys Gly Thr Ser Leu Asn Pro 
145                 150                 155                 160 


Leu Gln Phe Asp Asn Pro Ala Glu Leu Tyr Val Glu Asp Thr Gly Asp 
                165                 170                 175     


Ile Tyr Ile Val Asp Gly Asp Gly Gly Leu Asn Asn Arg Leu Ile Lys 
            180                 185                 190         


Leu Ser Gln Asp Phe Met Ile Leu Trp Leu His Gly Glu Asn Gly Thr 
        195                 200                 205             


Gly Pro Ala Lys Phe Asn Ile Pro His Ser Val Thr Leu Asp Ser Ala 
    210                 215                 220                 


Gly Arg Val Trp Val Ala Asp Arg Gly Asn Lys Arg Ile Gln Val Phe 
225                 230                 235                 240 


Asp Lys Asp Thr Gly Glu Trp Leu Gly Ala Trp Asn Asn Cys Phe Thr 
                245                 250                 255     


Glu Glu Gly Pro Ser Ser Val Arg Phe Thr Pro Asp Gly Lys Tyr Leu 
            260                 265                 270         


Ile Val Ala Gln Leu Asn Leu Ser Arg Leu Ser Val Val Ala Ala Pro 
        275                 280                 285             


Pro Val Gly Ser Ile Gly Glu Cys Ser Val Ile Ser Thr Ile Gln Leu 
    290                 295                 300                 


Ala Asp Gln Val Leu Pro His Leu Leu Glu Val Asp Arg Lys Thr Gly 
305                 310                 315                 320 


Ala Val Tyr Val Ala Glu Ile Gly Ala Lys Gln Val Gln Lys Tyr Val 
                325                 330                 335     


Pro Leu Asn Ser Tyr Val Pro Ser Phe Gly Ser 
            340                 345         


<210>  9367
<211>  150
<212>  PRT
<213>  Homo Sapiens

<400>  9367

Met Ile Leu Trp Leu His Gly Glu Asn Gly Thr Gly Pro Ala Lys Phe 
1               5                   10                  15      


Asn Ile Pro His Ser Val Thr Leu Asp Ser Ala Gly Arg Val Trp Val 
            20                  25                  30          


Ala Asp Arg Gly Asn Lys Arg Ile Gln Val Phe Asp Lys Asp Thr Gly 
        35                  40                  45              


Glu Trp Leu Gly Ala Trp Asn Asn Cys Phe Thr Glu Glu Gly Pro Ser 
    50                  55                  60                  


Ser Val Arg Phe Thr Pro Asp Gly Lys Tyr Leu Ile Val Ala Gln Leu 
65                  70                  75                  80  


Asn Leu Ser Arg Leu Ser Val Val Ala Ala Pro Pro Val Gly Ser Ile 
                85                  90                  95      


Gly Glu Cys Ser Val Ile Ser Thr Ile Gln Leu Ala Asp Gln Val Leu 
            100                 105                 110         


Pro His Leu Leu Glu Val Asp Arg Lys Thr Gly Ala Val Tyr Val Ala 
        115                 120                 125             


Glu Ile Gly Ala Lys Gln Val Gln Lys Tyr Val Pro Leu Asn Ser Tyr 
    130                 135                 140                 


Val Pro Ser Phe Gly Ser 
145                 150 


<210>  9368
<211>  1247
<212>  PRT
<213>  Homo Sapiens

<400>  9368

Met Leu Ala Ser Ser Ser Arg Ile Arg Ala Ala Trp Thr Arg Ala Leu 
1               5                   10                  15      


Leu Leu Pro Leu Leu Leu Ala Gly Pro Val Gly Cys Leu Ser Arg Gln 
            20                  25                  30          


Glu Leu Phe Pro Phe Gly Pro Gly Gln Gly Asp Leu Glu Leu Glu Asp 
        35                  40                  45              


Gly Asp Asp Phe Val Ser Pro Ala Leu Glu Leu Ser Gly Ala Leu Arg 
    50                  55                  60                  


Phe Tyr Asp Arg Ser Asp Ile Asp Ala Val Tyr Val Thr Thr Asn Gly 
65                  70                  75                  80  


Ile Ile Ala Thr Ser Glu Pro Pro Ala Lys Glu Ser His Pro Gly Leu 
                85                  90                  95      


Phe Pro Pro Thr Phe Gly Ala Val Ala Pro Phe Leu Ala Asp Leu Asp 
            100                 105                 110         


Thr Thr Asp Gly Leu Gly Lys Val Tyr Tyr Arg Glu Asp Leu Ser Pro 
        115                 120                 125             


Ser Ile Thr Gln Arg Ala Ala Glu Cys Val His Arg Gly Phe Pro Glu 
    130                 135                 140                 


Ile Ser Phe Gln Pro Ser Ser Ala Val Val Val Thr Trp Glu Ser Val 
145                 150                 155                 160 


Ala Pro Tyr Gln Gly Pro Ser Arg Asp Pro Asp Gln Lys Gly Lys Arg 
                165                 170                 175     


Asn Thr Phe Gln Ala Val Leu Ala Ser Ser Asp Ser Ser Ser Tyr Ala 
            180                 185                 190         


Ile Phe Leu Tyr Pro Glu Asp Gly Leu Gln Phe His Thr Thr Phe Ser 
        195                 200                 205             


Lys Lys Glu Asn Asn Gln Val Pro Ala Val Val Ala Phe Ser Gln Gly 
    210                 215                 220                 


Ser Val Gly Phe Leu Trp Lys Ser Asn Gly Ala Tyr Asn Ile Phe Ala 
225                 230                 235                 240 


Asn Asp Arg Glu Ser Val Glu Asn Leu Ala Lys Ser Ser Asn Ser Gly 
                245                 250                 255     


Gln Gln Gly Val Trp Val Phe Glu Ile Gly Ser Pro Ala Thr Thr Asn 
            260                 265                 270         


Gly Val Val Pro Ala Asp Val Ile Leu Gly Thr Glu Asp Gly Ala Glu 
        275                 280                 285             


Tyr Asp Asp Glu Asp Glu Asp Tyr Asp Leu Ala Thr Thr Arg Leu Gly 
    290                 295                 300                 


Leu Glu Asp Val Gly Thr Thr Pro Phe Ser Tyr Lys Ala Leu Arg Arg 
305                 310                 315                 320 


Gly Gly Ala Asp Thr Tyr Ser Val Pro Ser Val Leu Ser Pro Arg Arg 
                325                 330                 335     


Ala Ala Thr Glu Arg Pro Leu Gly Pro Pro Thr Glu Arg Thr Arg Ser 
            340                 345                 350         


Phe Gln Leu Ala Val Glu Thr Phe His Gln Gln His Pro Gln Val Ile 
        355                 360                 365             


Asp Val Asp Glu Val Glu Glu Thr Gly Val Val Phe Ser Tyr Asn Thr 
    370                 375                 380                 


Asp Ser Arg Gln Thr Cys Ala Asn Asn Arg His Gln Cys Ser Val His 
385                 390                 395                 400 


Ala Glu Cys Arg Asp Tyr Ala Thr Gly Phe Cys Cys Ser Cys Val Ala 
                405                 410                 415     


Gly Tyr Thr Gly Asn Gly Arg Gln Cys Val Ala Glu Gly Ser Pro Gln 
            420                 425                 430         


Arg Val Asn Gly Lys Val Lys Gly Arg Ile Phe Val Gly Ser Ser Gln 
        435                 440                 445             


Val Pro Ile Val Phe Glu Asn Thr Asp Leu His Ser Tyr Val Val Met 
    450                 455                 460                 


Asn His Gly Arg Ser Tyr Thr Ala Ile Ser Thr Ile Pro Glu Thr Val 
465                 470                 475                 480 


Gly Tyr Ser Leu Leu Pro Leu Ala Pro Val Gly Gly Ile Ile Gly Trp 
                485                 490                 495     


Met Phe Ala Val Glu Gln Asp Gly Phe Lys Asn Gly Phe Ser Ile Thr 
            500                 505                 510         


Gly Gly Glu Phe Thr Arg Gln Ala Glu Val Thr Phe Val Gly His Pro 
        515                 520                 525             


Gly Asn Leu Val Ile Lys Gln Arg Phe Ser Gly Ile Asp Glu His Gly 
    530                 535                 540                 


His Leu Thr Ile Asp Thr Glu Leu Glu Gly Arg Val Pro Gln Ile Pro 
545                 550                 555                 560 


Phe Gly Ser Ser Val His Ile Glu Pro Tyr Thr Glu Leu Tyr His Tyr 
                565                 570                 575     


Ser Thr Ser Val Ile Thr Ser Ser Ser Thr Arg Glu Tyr Thr Val Thr 
            580                 585                 590         


Glu Pro Glu Arg Asp Gly Ala Ser Pro Ser Arg Ile Tyr Thr Tyr Gln 
        595                 600                 605             


Trp Arg Gln Thr Ile Thr Phe Gln Glu Cys Val His Asp Asp Ser Arg 
    610                 615                 620                 


Pro Ala Leu Pro Ser Thr Gln Gln Leu Ser Val Asp Ser Val Phe Val 
625                 630                 635                 640 


Leu Tyr Asn Gln Glu Glu Lys Ile Leu Arg Tyr Ala Leu Ser Asn Ser 
                645                 650                 655     


Ile Gly Pro Val Arg Glu Gly Ser Pro Asp Ala Leu Gln Asn Pro Cys 
            660                 665                 670         


Tyr Ile Gly Thr His Gly Cys Asp Thr Asn Ala Ala Cys Arg Pro Gly 
        675                 680                 685             


Pro Arg Thr Gln Phe Thr Cys Glu Cys Ser Ile Gly Phe Arg Gly Asp 
    690                 695                 700                 


Gly Arg Thr Cys Tyr Asp Ile Asp Glu Cys Ser Glu Gln Pro Ser Val 
705                 710                 715                 720 


Cys Gly Ser His Thr Ile Cys Asn Asn His Pro Gly Thr Phe Arg Cys 
                725                 730                 735     


Glu Cys Val Glu Gly Tyr Gln Phe Ser Asp Glu Gly Thr Cys Val Ala 
            740                 745                 750         


Val Val Asp Gln Arg Pro Ile Asn Tyr Cys Glu Thr Gly Leu His Asn 
        755                 760                 765             


Cys Asp Ile Pro Gln Arg Ala Gln Cys Ile Tyr Thr Gly Gly Ser Ser 
    770                 775                 780                 


Tyr Thr Cys Ser Cys Leu Pro Gly Phe Ser Gly Asp Gly Gln Ala Cys 
785                 790                 795                 800 


Gln Asp Val Asp Glu Cys Gln Pro Ser Arg Cys His Pro Asp Ala Phe 
                805                 810                 815     


Cys Tyr Asn Thr Pro Gly Ser Phe Thr Cys Gln Cys Lys Pro Gly Tyr 
            820                 825                 830         


Gln Gly Asp Gly Phe Arg Cys Val Pro Gly Glu Val Glu Lys Thr Arg 
        835                 840                 845             


Cys Gln His Glu Arg Glu His Ile Leu Gly Ala Ala Gly Ala Thr Asp 
    850                 855                 860                 


Pro Gln Arg Pro Ile Pro Pro Gly Leu Phe Val Pro Glu Cys Asp Ala 
865                 870                 875                 880 


His Gly His Tyr Ala Pro Thr Gln Cys His Gly Ser Thr Gly Tyr Cys 
                885                 890                 895     


Trp Cys Val Asp Arg Asp Gly Arg Glu Val Glu Gly Thr Arg Thr Arg 
            900                 905                 910         


Pro Gly Met Thr Pro Pro Cys Leu Ser Thr Val Ala Pro Pro Ile His 
        915                 920                 925             


Gln Gly Pro Ala Val Pro Thr Ala Val Ile Pro Leu Pro Pro Gly Thr 
    930                 935                 940                 


His Leu Leu Phe Ala Gln Thr Gly Lys Ile Glu Arg Leu Pro Leu Glu 
945                 950                 955                 960 


Gly Asn Thr Met Arg Lys Thr Glu Ala Lys Ala Phe Leu His Val Pro 
                965                 970                 975     


Ala Lys Val Ile Ile Gly Leu Ala Phe Asp Cys Val Asp Lys Met Val 
            980                 985                 990         


Tyr Trp Thr Asp Ile Thr Glu Pro  Ser Ile Gly Arg Ala  Ser Leu His 
        995                 1000                 1005             


Gly Gly  Glu Pro Thr Thr Ile  Ile Arg Gln Asp Leu  Gly Ser Pro 
    1010                 1015                 1020             


Glu Gly  Ile Ala Val Asp His  Leu Gly Arg Asn Ile  Phe Trp Thr 
    1025                 1030                 1035             


Asp Ser  Asn Leu Asp Arg Ile  Glu Val Ala Lys Leu  Asp Gly Thr 
    1040                 1045                 1050             


Gln Arg  Arg Val Leu Phe Glu  Thr Asp Leu Val Asn  Pro Arg Gly 
    1055                 1060                 1065             


Ile Val  Thr Asp Ser Val Arg  Gly Asn Leu Tyr Trp  Thr Asp Trp 
    1070                 1075                 1080             


Asn Arg  Asp Asn Pro Lys Ile  Glu Thr Ser Tyr Met  Asp Gly Thr 
    1085                 1090                 1095             


Asn Arg  Arg Ile Leu Val Gln  Asp Asp Leu Gly Leu  Pro Asn Gly 
    1100                 1105                 1110             


Leu Thr  Phe Asp Ala Phe Ser  Ser Gln Leu Cys Trp  Val Asp Ala 
    1115                 1120                 1125             


Gly Thr  Asn Arg Ala Glu Cys  Leu Asn Pro Ser Gln  Pro Ser Arg 
    1130                 1135                 1140             


Arg Lys  Ala Leu Glu Gly Leu  Gln Tyr Pro Phe Ala  Val Thr Ser 
    1145                 1150                 1155             


Tyr Gly  Lys Asn Leu Tyr Phe  Thr Asp Trp Lys Met  Asn Ser Val 
    1160                 1165                 1170             


Val Ala  Leu Asp Leu Ala Ile  Ser Lys Glu Thr Asp  Ala Phe Gln 
    1175                 1180                 1185             


Pro His  Lys Gln Thr Arg Leu  Tyr Gly Ile Thr Thr  Ala Leu Ser 
    1190                 1195                 1200             


Gln Cys  Pro Gln Gly His Asn  Tyr Cys Ser Val Asn  Asn Gly Gly 
    1205                 1210                 1215             


Cys Thr  His Leu Cys Leu Ala  Thr Pro Gly Ser Arg  Thr Cys Arg 
    1220                 1225                 1230             


Cys Pro  Asp Asn Thr Leu Gly  Val Asp Cys Ile Glu  Gln Lys 
    1235                 1240                 1245         


<210>  9369
<211>  1114
<212>  PRT
<213>  Homo Sapiens

<400>  9369

Met Leu Ala Ser Ser Ser Arg Ile Arg Ala Ala Trp Thr Arg Ala Leu 
1               5                   10                  15      


Leu Leu Pro Leu Leu Leu Ala Gly Pro Val Gly Cys Leu Ser Arg Gln 
            20                  25                  30          


Glu Leu Phe Pro Phe Gly Pro Gly Gln Gly Asp Leu Glu Leu Glu Asp 
        35                  40                  45              


Gly Asp Asp Phe Val Ser Pro Ala Leu Glu Leu Ser Gly Ala Leu Arg 
    50                  55                  60                  


Phe Tyr Asp Arg Ser Asp Ile Asp Ala Val Tyr Val Thr Thr Asn Gly 
65                  70                  75                  80  


Ile Ile Ala Thr Ser Glu Pro Pro Ala Lys Glu Ser His Pro Gly Leu 
                85                  90                  95      


Phe Pro Pro Thr Phe Gly Ala Val Ala Pro Phe Leu Ala Asp Leu Asp 
            100                 105                 110         


Thr Thr Asp Gly Leu Gly Lys Val Tyr Tyr Arg Glu Asp Leu Ser Pro 
        115                 120                 125             


Ser Ile Thr Gln Arg Ala Ala Glu Cys Val His Arg Gly Phe Pro Glu 
    130                 135                 140                 


Ile Ser Phe Gln Pro Ser Ser Ala Val Val Val Thr Trp Glu Ser Val 
145                 150                 155                 160 


Ala Pro Tyr Gln Gly Pro Ser Arg Asp Pro Asp Gln Lys Gly Lys Arg 
                165                 170                 175     


Asn Thr Phe Gln Ala Val Leu Ala Ser Ser Asp Ser Ser Ser Tyr Ala 
            180                 185                 190         


Ile Phe Leu Tyr Pro Glu Asp Gly Leu Gln Phe His Thr Thr Phe Ser 
        195                 200                 205             


Lys Lys Glu Asn Asn Gln Val Pro Ala Val Val Ala Phe Ser Gln Gly 
    210                 215                 220                 


Ser Val Gly Phe Leu Trp Lys Ser Asn Gly Ala Tyr Asn Ile Phe Ala 
225                 230                 235                 240 


Asn Asp Arg Glu Ser Val Glu Asn Leu Ala Lys Ser Ser Asn Ser Gly 
                245                 250                 255     


Gln Gln Gly Val Trp Val Phe Glu Ile Gly Ser Pro Ala Thr Thr Asn 
            260                 265                 270         


Gly Val Val Pro Ala Asp Val Ile Leu Gly Thr Glu Asp Gly Ala Glu 
        275                 280                 285             


Tyr Asp Asp Glu Asp Glu Asp Tyr Asp Leu Ala Thr Thr Arg Leu Gly 
    290                 295                 300                 


Leu Glu Asp Val Gly Thr Thr Pro Phe Ser Tyr Lys Ala Leu Arg Arg 
305                 310                 315                 320 


Gly Gly Ala Asp Thr Tyr Ser Val Pro Ser Val Leu Ser Pro Arg Arg 
                325                 330                 335     


Ala Ala Thr Glu Arg Pro Leu Gly Pro Pro Thr Glu Arg Thr Arg Ser 
            340                 345                 350         


Phe Gln Leu Ala Val Glu Thr Phe His Gln Gln His Pro Gln Val Ile 
        355                 360                 365             


Asp Val Asp Glu Val Glu Glu Thr Gly Val Val Phe Ser Tyr Asn Thr 
    370                 375                 380                 


Asp Ser Arg Gln Thr Cys Ala Asn Asn Arg His Gln Cys Ser Val His 
385                 390                 395                 400 


Ala Glu Cys Arg Asp Tyr Ala Thr Gly Phe Cys Cys Ser Cys Val Ala 
                405                 410                 415     


Gly Tyr Thr Gly Asn Gly Arg Gln Cys Val Ala Glu Gly Ser Pro Gln 
            420                 425                 430         


Arg Val Asn Gly Lys Val Lys Gly Arg Ile Phe Val Gly Ser Ser Gln 
        435                 440                 445             


Val Pro Ile Val Phe Glu Asn Thr Asp Leu His Ser Tyr Val Val Met 
    450                 455                 460                 


Asn His Gly Arg Ser Tyr Thr Ala Ile Ser Thr Ile Pro Glu Thr Val 
465                 470                 475                 480 


Gly Tyr Ser Leu Leu Pro Leu Ala Pro Val Gly Gly Ile Ile Gly Trp 
                485                 490                 495     


Met Phe Ala Val Glu Gln Asp Gly Phe Lys Asn Gly Phe Ser Ile Thr 
            500                 505                 510         


Gly Gly Glu Phe Thr Arg Gln Ala Glu Val Thr Phe Val Gly His Pro 
        515                 520                 525             


Gly Asn Leu Val Ile Lys Gln Arg Phe Ser Gly Ile Asp Glu His Gly 
    530                 535                 540                 


His Leu Thr Ile Asp Thr Glu Leu Glu Gly Arg Val Pro Gln Ile Pro 
545                 550                 555                 560 


Phe Gly Ser Ser Val His Ile Glu Pro Tyr Thr Glu Leu Tyr His Tyr 
                565                 570                 575     


Ser Thr Ser Val Ile Thr Ser Ser Ser Thr Arg Glu Tyr Thr Val Thr 
            580                 585                 590         


Glu Pro Glu Arg Asp Gly Ala Ser Pro Ser Arg Ile Tyr Thr Tyr Gln 
        595                 600                 605             


Trp Arg Gln Thr Ile Thr Phe Gln Glu Cys Val His Asp Asp Ser Arg 
    610                 615                 620                 


Pro Ala Leu Pro Ser Thr Gln Gln Leu Ser Val Asp Ser Val Phe Val 
625                 630                 635                 640 


Leu Tyr Asn Gln Glu Glu Lys Ile Leu Arg Tyr Ala Leu Ser Asn Ser 
                645                 650                 655     


Ile Gly Pro Val Arg Glu Gly Ser Pro Asp Ala Leu Gln Asn Pro Cys 
            660                 665                 670         


Tyr Ile Gly Thr His Gly Cys Asp Thr Asn Ala Ala Cys Arg Pro Gly 
        675                 680                 685             


Pro Arg Thr Gln Phe Thr Cys Glu Cys Ser Ile Gly Phe Arg Gly Asp 
    690                 695                 700                 


Gly Arg Thr Cys Tyr Glu Val Glu Lys Thr Arg Cys Gln His Glu Arg 
705                 710                 715                 720 


Glu His Ile Leu Gly Ala Ala Gly Ala Thr Asp Pro Gln Arg Pro Ile 
                725                 730                 735     


Pro Pro Gly Leu Phe Val Pro Glu Cys Asp Ala His Gly His Tyr Ala 
            740                 745                 750         


Pro Thr Gln Cys His Gly Ser Thr Gly Tyr Cys Trp Cys Val Asp Arg 
        755                 760                 765             


Asp Gly Arg Glu Val Glu Gly Thr Arg Thr Arg Pro Gly Met Thr Pro 
    770                 775                 780                 


Pro Cys Leu Ser Thr Val Ala Pro Pro Ile His Gln Gly Pro Ala Val 
785                 790                 795                 800 


Pro Thr Ala Val Ile Pro Leu Pro Pro Gly Thr His Leu Leu Phe Ala 
                805                 810                 815     


Gln Thr Gly Lys Ile Glu Arg Leu Pro Leu Glu Gly Asn Thr Met Arg 
            820                 825                 830         


Lys Thr Glu Ala Lys Ala Phe Leu His Val Pro Ala Lys Val Ile Ile 
        835                 840                 845             


Gly Leu Ala Phe Asp Cys Val Asp Lys Met Val Tyr Trp Thr Asp Ile 
    850                 855                 860                 


Thr Glu Pro Ser Ile Gly Arg Ala Ser Leu His Gly Gly Glu Pro Thr 
865                 870                 875                 880 


Thr Ile Ile Arg Gln Asp Leu Gly Ser Pro Glu Gly Ile Ala Val Asp 
                885                 890                 895     


His Leu Gly Arg Asn Ile Phe Trp Thr Asp Ser Asn Leu Asp Arg Ile 
            900                 905                 910         


Glu Val Ala Lys Leu Asp Gly Thr Gln Arg Arg Val Leu Phe Glu Thr 
        915                 920                 925             


Asp Leu Val Asn Pro Arg Gly Ile Val Thr Asp Ser Val Arg Gly Asn 
    930                 935                 940                 


Leu Tyr Trp Thr Asp Trp Asn Arg Asp Asn Pro Lys Ile Glu Thr Ser 
945                 950                 955                 960 


Tyr Met Asp Gly Thr Asn Arg Arg Ile Leu Val Gln Asp Asp Leu Gly 
                965                 970                 975     


Leu Pro Asn Gly Leu Thr Phe Asp Ala Phe Ser Ser Gln Leu Cys Trp 
            980                 985                 990         


Val Asp Ala Gly Thr Asn Arg Ala  Glu Cys Leu Asn Pro  Ser Gln Pro 
        995                 1000                 1005             


Ser Arg  Arg Lys Ala Leu Glu  Gly Leu Gln Tyr Pro  Phe Ala Val 
    1010                 1015                 1020             


Thr Ser  Tyr Gly Lys Asn Leu  Tyr Phe Thr Asp Trp  Lys Met Asn 
    1025                 1030                 1035             


Ser Val  Val Ala Leu Asp Leu  Ala Ile Ser Lys Glu  Thr Asp Ala 
    1040                 1045                 1050             


Phe Gln  Pro His Lys Gln Thr  Arg Leu Tyr Gly Ile  Thr Thr Ala 
    1055                 1060                 1065             


Leu Ser  Gln Cys Pro Gln Gly  His Asn Tyr Cys Ser  Val Asn Asn 
    1070                 1075                 1080             


Gly Gly  Cys Thr His Leu Cys  Leu Ala Thr Pro Gly  Ser Arg Thr 
    1085                 1090                 1095             


Cys Arg  Cys Pro Asp Asn Thr  Leu Gly Val Asp Cys  Ile Glu Gln 
    1100                 1105                 1110             


Lys 
    


<210>  9370
<211>  1375
<212>  PRT
<213>  Homo Sapiens

<400>  9370

Met Glu Gly Asp Arg Val Ala Gly Arg Pro Val Leu Ser Ser Leu Pro 
1               5                   10                  15      


Val Leu Leu Leu Leu Pro Leu Leu Met Leu Arg Ala Ala Ala Leu His 
            20                  25                  30          


Pro Asp Glu Leu Phe Pro His Gly Glu Ser Trp Gly Asp Gln Leu Leu 
        35                  40                  45              


Gln Glu Gly Asp Asp Glu Ser Ser Ala Val Val Lys Leu Ala Asn Pro 
    50                  55                  60                  


Leu His Phe Tyr Glu Ala Arg Phe Ser Asn Leu Tyr Val Gly Thr Asn 
65                  70                  75                  80  


Gly Ile Ile Ser Thr Gln Asp Phe Pro Arg Glu Thr Gln Tyr Val Asp 
                85                  90                  95      


Tyr Asp Phe Pro Thr Asp Phe Pro Ala Ile Ala Pro Phe Leu Ala Asp 
            100                 105                 110         


Ile Asp Thr Ser His Gly Arg Gly Arg Val Leu Tyr Arg Glu Asp Thr 
        115                 120                 125             


Ser Pro Ala Val Leu Gly Leu Ala Ala Arg Tyr Val Arg Ala Gly Phe 
    130                 135                 140                 


Pro Arg Ser Ala Arg Phe Thr Pro Thr His Ala Phe Leu Ala Thr Trp 
145                 150                 155                 160 


Glu Gln Val Gly Ala Tyr Glu Glu Val Lys Arg Gly Ala Leu Pro Ser 
                165                 170                 175     


Gly Glu Leu Asn Thr Phe Gln Ala Val Leu Ala Ser Asp Gly Ser Asp 
            180                 185                 190         


Ser Tyr Ala Leu Phe Leu Tyr Pro Ala Asn Gly Leu Gln Phe Leu Gly 
        195                 200                 205             


Thr Arg Pro Lys Glu Ser Tyr Asn Val Gln Leu Gln Leu Pro Ala Arg 
    210                 215                 220                 


Val Gly Phe Cys Arg Gly Glu Ala Asp Asp Leu Lys Ser Glu Gly Pro 
225                 230                 235                 240 


Tyr Phe Ser Leu Thr Ser Thr Glu Gln Ser Val Lys Asn Leu Tyr Gln 
                245                 250                 255     


Leu Ser Asn Leu Gly Ile Pro Gly Val Trp Ala Phe His Ile Gly Ser 
            260                 265                 270         


Thr Ser Pro Leu Asp Asn Val Arg Pro Ala Ala Val Gly Asp Leu Ser 
        275                 280                 285             


Ala Ala His Ser Ser Val Pro Leu Gly Arg Ser Phe Ser His Ala Thr 
    290                 295                 300                 


Ala Leu Glu Ser Asp Tyr Asn Glu Asp Asn Leu Asp Tyr Tyr Asp Val 
305                 310                 315                 320 


Asn Glu Glu Glu Ala Glu Tyr Leu Pro Gly Glu Pro Glu Glu Ala Leu 
                325                 330                 335     


Asn Gly His Ser Ser Ile Asp Val Ser Phe Gln Ser Lys Val Asp Thr 
            340                 345                 350         


Lys Pro Leu Glu Glu Ser Ser Thr Leu Asp Pro His Thr Lys Glu Gly 
        355                 360                 365             


Thr Ser Leu Gly Glu Val Gly Gly Pro Asp Leu Lys Gly Gln Val Glu 
    370                 375                 380                 


Pro Trp Asp Glu Arg Glu Thr Arg Ser Pro Ala Pro Pro Glu Val Asp 
385                 390                 395                 400 


Arg Asp Ser Leu Ala Pro Ser Trp Glu Thr Pro Pro Pro Tyr Pro Glu 
                405                 410                 415     


Asn Gly Ser Ile Gln Pro Tyr Pro Asp Gly Gly Pro Val Pro Ser Glu 
            420                 425                 430         


Met Asp Val Pro Pro Ala His Pro Glu Glu Glu Ile Val Leu Arg Ser 
        435                 440                 445             


Tyr Pro Ala Ser Gly His Thr Thr Pro Leu Ser Arg Gly Thr Tyr Glu 
    450                 455                 460                 


Val Gly Leu Glu Asp Asn Ile Gly Ser Asn Thr Glu Val Phe Thr Tyr 
465                 470                 475                 480 


Asn Ala Ala Asn Lys Glu Thr Cys Glu His Asn His Arg Gln Cys Ser 
                485                 490                 495     


Arg His Ala Phe Cys Thr Asp Tyr Ala Thr Gly Phe Cys Cys His Cys 
            500                 505                 510         


Gln Ser Lys Phe Tyr Gly Asn Gly Lys His Cys Leu Pro Glu Gly Ala 
        515                 520                 525             


Pro His Arg Val Asn Gly Lys Val Ser Gly His Leu His Val Gly His 
    530                 535                 540                 


Thr Pro Val His Phe Thr Asp Val Asp Leu His Ala Tyr Ile Val Gly 
545                 550                 555                 560 


Asn Asp Gly Arg Ala Tyr Thr Ala Ile Ser His Ile Pro Gln Pro Ala 
                565                 570                 575     


Ala Gln Ala Leu Leu Pro Leu Thr Pro Ile Gly Gly Leu Phe Gly Trp 
            580                 585                 590         


Leu Phe Ala Leu Glu Lys Pro Gly Ser Glu Asn Gly Phe Ser Leu Ala 
        595                 600                 605             


Gly Ala Ala Phe Thr His Asp Met Glu Val Thr Phe Tyr Pro Gly Glu 
    610                 615                 620                 


Glu Thr Val Arg Ile Thr Gln Thr Ala Glu Gly Leu Asp Pro Glu Asn 
625                 630                 635                 640 


Tyr Leu Ser Ile Lys Thr Asn Ile Gln Gly Gln Val Pro Tyr Val Ser 
                645                 650                 655     


Ala Asn Phe Thr Ala His Ile Ser Pro Tyr Lys Glu Leu Tyr His Tyr 
            660                 665                 670         


Ser Asp Ser Thr Val Thr Ser Thr Ser Ser Arg Asp Tyr Ser Leu Thr 
        675                 680                 685             


Phe Gly Ala Ile Asn Gln Thr Trp Ser Tyr Arg Ile His Gln Asn Ile 
    690                 695                 700                 


Thr Tyr Gln Val Cys Arg His Ala Pro Arg His Pro Ser Phe Pro Thr 
705                 710                 715                 720 


Thr Gln Gln Leu Asn Val Asp Arg Val Phe Ala Leu Tyr Asn Asp Glu 
                725                 730                 735     


Glu Arg Val Leu Arg Phe Ala Val Thr Asn Gln Ile Gly Pro Val Lys 
            740                 745                 750         


Glu Asp Ser Asp Pro Thr Pro Gly Asn Pro Cys Tyr Asp Gly Ser His 
        755                 760                 765             


Met Cys Asp Thr Thr Ala Arg Cys His Pro Gly Thr Gly Val Asp Tyr 
    770                 775                 780                 


Thr Cys Glu Cys Ala Ser Gly Tyr Gln Gly Asp Gly Arg Asn Cys Val 
785                 790                 795                 800 


Asp Glu Asn Glu Cys Ala Thr Gly Phe His Arg Cys Gly Pro Asn Ser 
                805                 810                 815     


Val Cys Ile Asn Leu Pro Gly Ser Tyr Arg Cys Glu Cys Arg Ser Gly 
            820                 825                 830         


Tyr Glu Phe Ala Asp Asp Arg His Thr Cys Ile Leu Ile Thr Pro Pro 
        835                 840                 845             


Ala Asn Pro Cys Glu Asp Gly Ser His Thr Cys Ala Pro Ala Gly Gln 
    850                 855                 860                 


Ala Arg Cys Val His His Gly Gly Ser Thr Phe Ser Cys Ala Cys Leu 
865                 870                 875                 880 


Pro Gly Tyr Ala Gly Asp Gly His Gln Cys Thr Asp Val Asp Glu Cys 
                885                 890                 895     


Ser Glu Asn Arg Cys His Pro Ala Ala Thr Cys Tyr Asn Thr Pro Gly 
            900                 905                 910         


Ser Phe Ser Cys Arg Cys Gln Pro Gly Tyr Tyr Gly Asp Gly Phe Gln 
        915                 920                 925             


Cys Ile Pro Asp Ser Thr Ser Ser Leu Thr Pro Cys Glu Gln Gln Gln 
    930                 935                 940                 


Arg His Ala Gln Ala Gln Tyr Ala Tyr Pro Gly Ala Arg Phe His Ile 
945                 950                 955                 960 


Pro Gln Cys Asp Glu Gln Gly Asn Phe Leu Pro Leu Gln Cys His Gly 
                965                 970                 975     


Ser Thr Gly Phe Cys Trp Cys Val Asp Pro Asp Gly His Glu Val Pro 
            980                 985                 990         


Gly Thr Gln Thr Pro Pro Gly Ser  Thr Pro Pro His Cys  Gly Pro Ser 
        995                 1000                 1005             


Pro Glu  Pro Thr Gln Arg Pro  Pro Thr Ile Cys Glu  Arg Trp Arg 
    1010                 1015                 1020             


Glu Asn  Leu Leu Glu His Tyr  Gly Gly Thr Pro Arg  Asp Asp Gln 
    1025                 1030                 1035             


Tyr Val  Pro Gln Cys Asp Asp  Leu Gly His Phe Ile  Pro Leu Gln 
    1040                 1045                 1050             


Cys His  Gly Lys Ser Asp Phe  Cys Trp Cys Val Asp  Lys Asp Gly 
    1055                 1060                 1065             


Arg Glu  Val Gln Gly Thr Arg  Ser Gln Pro Gly Thr  Thr Pro Ala 
    1070                 1075                 1080             


Cys Ile  Pro Thr Val Ala Pro  Pro Met Val Arg Pro  Thr Pro Arg 
    1085                 1090                 1095             


Pro Asp  Val Thr Pro Pro Ser  Val Gly Thr Phe Leu  Leu Tyr Thr 
    1100                 1105                 1110             


Gln Gly  Gln Gln Ile Gly Tyr  Leu Pro Leu Asn Gly  Thr Arg Leu 
    1115                 1120                 1125             


Gln Lys  Asp Ala Ala Lys Thr  Leu Leu Ser Leu His  Gly Ser Ile 
    1130                 1135                 1140             


Ile Val  Gly Ile Asp Tyr Asp  Cys Arg Glu Arg Met  Val Tyr Trp 
    1145                 1150                 1155             


Thr Asp  Val Ala Gly Arg Thr  Ile Ser Arg Ala Gly  Leu Glu Leu 
    1160                 1165                 1170             


Gly Ala  Glu Pro Glu Thr Ile  Val Asn Ser Gly Leu  Ile Ser Pro 
    1175                 1180                 1185             


Glu Gly  Leu Ala Ile Asp His  Ile Arg Arg Thr Met  Tyr Trp Thr 
    1190                 1195                 1200             


Asp Ser  Val Leu Asp Lys Ile  Glu Ser Ala Leu Leu  Asp Gly Ser 
    1205                 1210                 1215             


Glu Arg  Lys Val Leu Phe Tyr  Thr Asp Leu Val Asn  Pro Arg Ala 
    1220                 1225                 1230             


Ile Ala  Val Asp Pro Ile Arg  Gly Asn Leu Tyr Trp  Thr Asp Trp 
    1235                 1240                 1245             


Asn Arg  Glu Ala Pro Lys Ile  Glu Thr Ser Ser Leu  Asp Gly Glu 
    1250                 1255                 1260             


Asn Arg  Arg Ile Leu Ile Asn  Thr Asp Ile Gly Leu  Pro Asn Gly 
    1265                 1270                 1275             


Leu Thr  Phe Asp Pro Phe Ser  Lys Leu Leu Cys Trp  Ala Asp Ala 
    1280                 1285                 1290             


Gly Thr  Lys Lys Leu Glu Cys  Thr Leu Pro Asp Gly  Thr Gly Arg 
    1295                 1300                 1305             


Arg Val  Ile Gln Asn Asn Leu  Lys Tyr Pro Phe Ser  Ile Val Ser 
    1310                 1315                 1320             


Tyr Ala  Asp His Phe Tyr His  Thr Asp Trp Arg Arg  Asp Gly Val 
    1325                 1330                 1335             


Val Ser  Val Asn Lys His Ser  Gly Gln Phe Thr Asp  Glu Tyr Leu 
    1340                 1345                 1350             


Pro Glu  Gln Arg Ser His Leu  Tyr Gly Ile Thr Ala  Val Tyr Pro 
    1355                 1360                 1365             


Tyr Cys  Pro Thr Gly Arg Lys  
    1370                 1375 


<210>  9371
<211>  969
<212>  PRT
<213>  Homo Sapiens

<400>  9371

Met Glu Gly Asp Arg Val Ala Gly Arg Pro Val Leu Ser Ser Leu Pro 
1               5                   10                  15      


Val Leu Leu Leu Leu Pro Leu Leu Met Leu Arg Ala Ala Ala Leu His 
            20                  25                  30          


Pro Asp Glu Leu Phe Pro His Gly Glu Ser Trp Gly Asp Gln Leu Leu 
        35                  40                  45              


Gln Glu Gly Asp Asp Glu Ser Ser Ala Val Val Lys Leu Ala Asn Pro 
    50                  55                  60                  


Leu His Phe Tyr Glu Ala Arg Phe Ser Asn Leu Tyr Val Gly Thr Asn 
65                  70                  75                  80  


Gly Ile Ile Ser Thr Gln Asp Phe Pro Arg Glu Thr Gln Tyr Val Asp 
                85                  90                  95      


Tyr Asp Phe Pro Thr Asp Phe Pro Ala Ile Ala Pro Phe Leu Ala Asp 
            100                 105                 110         


Ile Asp Thr Ser His Gly Arg Gly Arg Val Leu Tyr Arg Val Asn Gly 
        115                 120                 125             


Lys Val Ser Gly His Leu His Val Gly His Thr Pro Val His Phe Thr 
    130                 135                 140                 


Asp Val Asp Leu His Ala Tyr Ile Val Gly Asn Asp Gly Arg Ala Tyr 
145                 150                 155                 160 


Thr Ala Ile Ser His Ile Pro Gln Pro Ala Ala Gln Ala Leu Leu Pro 
                165                 170                 175     


Leu Thr Pro Ile Gly Gly Leu Phe Gly Trp Leu Phe Ala Leu Glu Lys 
            180                 185                 190         


Pro Gly Ser Glu Asn Gly Phe Ser Leu Ala Gly Ala Ala Phe Thr His 
        195                 200                 205             


Asp Met Glu Val Thr Phe Tyr Pro Gly Glu Glu Thr Val Arg Ile Thr 
    210                 215                 220                 


Gln Thr Ala Glu Gly Leu Asp Pro Glu Asn Tyr Leu Ser Ile Lys Thr 
225                 230                 235                 240 


Asn Ile Gln Gly Gln Val Pro Tyr Val Ser Ala Asn Phe Thr Ala His 
                245                 250                 255     


Ile Ser Pro Tyr Lys Glu Leu Tyr His Tyr Ser Asp Ser Thr Val Thr 
            260                 265                 270         


Ser Thr Ser Ser Arg Asp Tyr Ser Leu Thr Phe Gly Ala Ile Asn Gln 
        275                 280                 285             


Thr Trp Ser Tyr Arg Ile His Gln Asn Ile Thr Tyr Gln Val Cys Arg 
    290                 295                 300                 


His Ala Pro Arg His Pro Ser Phe Pro Thr Thr Gln Gln Leu Asn Val 
305                 310                 315                 320 


Asp Arg Val Phe Ala Leu Tyr Asn Asp Glu Glu Arg Val Leu Arg Phe 
                325                 330                 335     


Ala Val Thr Asn Gln Ile Gly Pro Val Lys Glu Asp Ser Asp Pro Thr 
            340                 345                 350         


Pro Gly Asn Pro Cys Tyr Asp Gly Ser His Met Cys Asp Thr Thr Ala 
        355                 360                 365             


Arg Cys His Pro Gly Thr Gly Val Asp Tyr Thr Cys Glu Cys Ala Ser 
    370                 375                 380                 


Gly Tyr Gln Gly Asp Gly Arg Asn Cys Val Asp Glu Asn Glu Cys Ala 
385                 390                 395                 400 


Thr Gly Phe His Arg Cys Gly Pro Asn Ser Val Cys Ile Asn Leu Pro 
                405                 410                 415     


Gly Ser Tyr Arg Cys Glu Cys Arg Ser Gly Tyr Glu Phe Ala Asp Asp 
            420                 425                 430         


Arg His Thr Cys Ile Leu Ile Thr Pro Pro Ala Asn Pro Cys Glu Asp 
        435                 440                 445             


Gly Ser His Thr Cys Ala Pro Ala Gly Gln Ala Arg Cys Val His His 
    450                 455                 460                 


Gly Gly Ser Thr Phe Ser Cys Ala Cys Leu Pro Gly Tyr Ala Gly Asp 
465                 470                 475                 480 


Gly His Gln Cys Thr Asp Val Asp Glu Cys Ser Glu Asn Arg Cys His 
                485                 490                 495     


Pro Ala Ala Thr Cys Tyr Asn Thr Pro Gly Ser Phe Ser Cys Arg Cys 
            500                 505                 510         


Gln Pro Gly Tyr Tyr Gly Asp Gly Phe Gln Cys Ile Pro Asp Ser Thr 
        515                 520                 525             


Ser Ser Leu Thr Pro Cys Glu Gln Gln Gln Arg His Ala Gln Ala Gln 
    530                 535                 540                 


Tyr Ala Tyr Pro Gly Ala Arg Phe His Ile Pro Gln Cys Asp Glu Gln 
545                 550                 555                 560 


Gly Asn Phe Leu Pro Leu Gln Cys His Gly Ser Thr Gly Phe Cys Trp 
                565                 570                 575     


Cys Val Asp Pro Asp Gly His Glu Val Pro Gly Thr Gln Thr Pro Pro 
            580                 585                 590         


Gly Ser Thr Pro Pro His Cys Gly Pro Ser Pro Glu Pro Thr Gln Arg 
        595                 600                 605             


Pro Pro Thr Ile Cys Glu Arg Trp Arg Glu Asn Leu Leu Glu His Tyr 
    610                 615                 620                 


Gly Gly Thr Pro Arg Asp Asp Gln Tyr Val Pro Gln Cys Asp Asp Leu 
625                 630                 635                 640 


Gly His Phe Ile Pro Leu Gln Cys His Gly Lys Ser Asp Phe Cys Trp 
                645                 650                 655     


Cys Val Asp Lys Asp Gly Arg Glu Val Gln Gly Thr Arg Ser Gln Pro 
            660                 665                 670         


Gly Thr Thr Pro Ala Cys Ile Pro Thr Val Ala Pro Pro Met Val Arg 
        675                 680                 685             


Pro Thr Pro Arg Pro Asp Val Thr Pro Pro Ser Val Gly Thr Phe Leu 
    690                 695                 700                 


Leu Tyr Thr Gln Gly Gln Gln Ile Gly Tyr Leu Pro Leu Asn Gly Thr 
705                 710                 715                 720 


Arg Leu Gln Lys Asp Ala Ala Lys Thr Leu Leu Ser Leu His Gly Ser 
                725                 730                 735     


Ile Ile Val Gly Ile Asp Tyr Asp Cys Arg Glu Arg Met Val Tyr Trp 
            740                 745                 750         


Thr Asp Val Ala Gly Arg Thr Ile Ser Arg Ala Gly Leu Glu Leu Gly 
        755                 760                 765             


Ala Glu Pro Glu Thr Ile Val Asn Ser Gly Leu Ile Ser Pro Glu Gly 
    770                 775                 780                 


Leu Ala Ile Asp His Ile Arg Arg Thr Met Tyr Trp Thr Asp Ser Val 
785                 790                 795                 800 


Leu Asp Lys Ile Glu Ser Ala Leu Leu Asp Gly Ser Glu Arg Lys Val 
                805                 810                 815     


Leu Phe Tyr Thr Asp Leu Val Asn Pro Arg Ala Ile Ala Val Asp Pro 
            820                 825                 830         


Ile Arg Gly Asn Leu Tyr Trp Thr Asp Trp Asn Arg Glu Ala Pro Lys 
        835                 840                 845             


Ile Glu Thr Ser Ser Leu Asp Gly Glu Asn Arg Arg Ile Leu Ile Asn 
    850                 855                 860                 


Thr Asp Ile Gly Leu Pro Asn Gly Leu Thr Phe Asp Pro Phe Ser Lys 
865                 870                 875                 880 


Leu Leu Cys Trp Ala Asp Ala Gly Thr Lys Lys Leu Glu Cys Thr Leu 
                885                 890                 895     


Pro Asp Gly Thr Gly Arg Arg Val Ile Gln Asn Asn Leu Lys Tyr Pro 
            900                 905                 910         


Phe Ser Ile Val Ser Tyr Ala Asp His Phe Tyr His Thr Asp Trp Arg 
        915                 920                 925             


Arg Asp Gly Val Val Ser Val Asn Lys His Ser Gly Gln Phe Thr Asp 
    930                 935                 940                 


Glu Tyr Leu Pro Glu Gln Arg Ser His Leu Tyr Gly Ile Thr Ala Val 
945                 950                 955                 960 


Tyr Pro Tyr Cys Pro Thr Gly Arg Lys 
                965                 


<210>  9372
<211>  644
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9372

Xaa Tyr Ser Leu Thr Phe Gly Ala Ile Asn Gln Thr Trp Ser Tyr Arg 
1               5                   10                  15      


Ile His Gln Asn Ile Thr Tyr Gln Val Cys Arg His Ala Pro Arg His 
            20                  25                  30          


Pro Ser Phe Pro Thr Thr Gln Gln Leu Asn Val Asp Arg Val Phe Ala 
        35                  40                  45              


Leu Tyr Asn Asp Glu Glu Arg Val Leu Arg Phe Ala Val Thr Asn Gln 
    50                  55                  60                  


Ile Gly Pro Val Lys Glu Asp Ser Asp Pro Thr Pro Gly Asn Pro Cys 
65                  70                  75                  80  


Tyr Asp Gly Ser His Met Cys Asp Thr Thr Ala Arg Cys His Pro Gly 
                85                  90                  95      


Thr Gly Val Asp Tyr Thr Cys Glu Cys Ala Ser Gly Tyr Gln Gly Asp 
            100                 105                 110         


Gly Arg Asn Cys Val Asp Glu Asn Glu Cys Ala Thr Gly Phe His Arg 
        115                 120                 125             


Cys Gly Pro Asn Ser Val Cys Ile Asn Leu Pro Gly Ser Tyr Arg Cys 
    130                 135                 140                 


Glu Cys Arg Ser Gly Tyr Glu Phe Ala Asp Asp Arg His Thr Cys Ile 
145                 150                 155                 160 


Tyr Val Asp Glu Cys Ser Glu Asn Arg Cys His Pro Ala Ala Thr Cys 
                165                 170                 175     


Tyr Asn Thr Pro Gly Ser Phe Ser Cys Arg Cys Gln Pro Gly Tyr Tyr 
            180                 185                 190         


Gly Asp Gly Phe Gln Cys Ile Pro Asp Ser Thr Ser Ser Leu Thr Pro 
        195                 200                 205             


Cys Glu Gln Gln Gln Arg His Ala Gln Ala Gln Tyr Ala Tyr Pro Gly 
    210                 215                 220                 


Ala Arg Phe His Ile Pro Gln Cys Asp Glu Gln Gly Asn Phe Leu Pro 
225                 230                 235                 240 


Leu Gln Cys His Gly Ser Thr Gly Phe Cys Trp Cys Val Asp Pro Asp 
                245                 250                 255     


Gly His Glu Val Pro Gly Thr Gln Thr Pro Pro Gly Ser Thr Pro Pro 
            260                 265                 270         


His Cys Gly Pro Ser Pro Glu Pro Thr Gln Arg Pro Pro Thr Ile Cys 
        275                 280                 285             


Glu Arg Trp Arg Glu Asn Leu Leu Glu His Tyr Gly Gly Thr Pro Arg 
    290                 295                 300                 


Asp Asp Gln Tyr Val Pro Gln Cys Asp Asp Leu Gly His Phe Ile Pro 
305                 310                 315                 320 


Leu Gln Cys His Gly Lys Ser Asp Phe Cys Trp Cys Val Asp Lys Asp 
                325                 330                 335     


Gly Arg Glu Val Gln Gly Thr Arg Ser Gln Pro Gly Thr Thr Pro Ala 
            340                 345                 350         


Cys Ile Pro Thr Val Ala Pro Pro Met Val Arg Pro Thr Pro Arg Pro 
        355                 360                 365             


Asp Val Thr Pro Pro Ser Val Gly Thr Phe Leu Leu Tyr Thr Gln Gly 
    370                 375                 380                 


Gln Gln Ile Gly Tyr Leu Pro Leu Asn Gly Thr Arg Leu Gln Lys Asp 
385                 390                 395                 400 


Ala Ala Lys Thr Leu Leu Ser Leu His Gly Ser Ile Ile Val Gly Ile 
                405                 410                 415     


Asp Tyr Asp Cys Arg Glu Arg Met Val Tyr Trp Thr Asp Val Ala Gly 
            420                 425                 430         


Arg Thr Ile Ser Arg Ala Gly Leu Glu Leu Gly Ala Glu Pro Glu Thr 
        435                 440                 445             


Ile Val Asn Ser Gly Leu Ile Ser Pro Glu Gly Leu Ala Ile Asp His 
    450                 455                 460                 


Ile Arg Arg Thr Met Tyr Trp Thr Asp Ser Val Leu Asp Lys Ile Glu 
465                 470                 475                 480 


Ser Ala Leu Leu Asp Gly Ser Glu Arg Lys Val Leu Phe Tyr Thr Asp 
                485                 490                 495     


Leu Val Asn Pro Arg Ala Ile Ala Val Asp Pro Ile Arg Gly Asn Leu 
            500                 505                 510         


Tyr Trp Thr Asp Trp Asn Arg Glu Ala Pro Lys Ile Glu Thr Ser Ser 
        515                 520                 525             


Leu Asp Gly Glu Asn Arg Arg Ile Leu Ile Asn Thr Asp Ile Gly Leu 
    530                 535                 540                 


Pro Asn Gly Leu Thr Phe Asp Pro Phe Ser Lys Leu Leu Cys Trp Ala 
545                 550                 555                 560 


Asp Ala Gly Thr Lys Lys Leu Glu Cys Thr Leu Pro Asp Gly Thr Gly 
                565                 570                 575     


Arg Arg Val Ile Gln Asn Asn Leu Lys Tyr Pro Phe Ser Ile Val Ser 
            580                 585                 590         


Tyr Ala Asp His Phe Tyr His Thr Asp Trp Arg Arg Asp Gly Val Val 
        595                 600                 605             


Ser Val Asn Lys His Ser Gly Gln Phe Thr Asp Glu Tyr Leu Pro Glu 
    610                 615                 620                 


Gln Arg Ser His Leu Tyr Gly Ile Thr Ala Val Tyr Pro Tyr Cys Pro 
625                 630                 635                 640 


Thr Gly Arg Lys 
                


<210>  9373
<211>  85
<212>  PRT
<213>  Homo Sapiens

<400>  9373

Met Glu Leu Cys Arg Ser Leu Ala Leu Leu Gly Gly Ser Leu Gly Leu 
1               5                   10                  15      


Met Phe Cys Leu Ile Ala Leu Ser Thr Asp Phe Trp Phe Glu Ala Val 
            20                  25                  30          


Gly Pro Thr His Ser Ala His Ser Gly Leu Trp Pro Thr Gly His Gly 
        35                  40                  45              


Asp Ile Ile Ser Gly His Gly Pro Leu Val Ser Thr Thr Ala Ala Phe 
    50                  55                  60                  


Ala Ala Gly Ala Leu Ser Leu Gly Ala His Cys Gly Gly Pro Arg Pro 
65                  70                  75                  80  


Gly Tyr Glu Thr Leu 
                85  


<210>  9374
<211>  142
<212>  PRT
<213>  Homo Sapiens

<400>  9374

Met Glu Leu Cys Arg Ser Leu Ala Leu Leu Gly Gly Ser Leu Gly Leu 
1               5                   10                  15      


Met Phe Cys Leu Ile Ala Leu Ser Thr Asp Phe Trp Phe Glu Ala Val 
            20                  25                  30          


Gly Pro Thr His Ser Ala His Ser Gly Leu Trp Pro Thr Gly His Gly 
        35                  40                  45              


Asp Ile Ile Ser Gly His Gly Pro Leu Val Ser Thr Thr Ala Ala Phe 
    50                  55                  60                  


Ala Ala Gly Lys Asp Ser Gly Leu Asp Trp Gly Ile Ala Ser Gln Arg 
65                  70                  75                  80  


Ile Pro Ala Glu Glu Leu Ser His Leu Ser Cys Pro Cys Pro Gln Pro 
                85                  90                  95      


Ser Pro Trp Trp Trp Pro Trp Arg Cys Thr Pro Ala Ser Gly Gly Thr 
            100                 105                 110         


Ser Leu His Thr Pro Arg Ser Arg Pro Ser Ser Pro Gly Pro Ser Thr 
        115                 120                 125             


Trp Ala Gly Ser Gln Leu Ser Ser Cys Ser Val Gln Val Pro 
    130                 135                 140         


<210>  9375
<211>  165
<212>  PRT
<213>  Homo Sapiens

<400>  9375

Met Glu Leu Cys Arg Ser Leu Ala Leu Leu Gly Gly Ser Leu Gly Leu 
1               5                   10                  15      


Met Phe Cys Leu Ile Ala Leu Ser Thr Asp Phe Trp Phe Glu Ala Val 
            20                  25                  30          


Gly Pro Thr His Ser Ala His Ser Gly Leu Trp Pro Thr Gly His Gly 
        35                  40                  45              


Asp Ile Ile Ser Gly Tyr Ile His Val Thr Gln Thr Phe Ser Ile Met 
    50                  55                  60                  


Ala Val Leu Trp Ala Leu Val Ser Val Ser Phe Leu Val Leu Ser Cys 
65                  70                  75                  80  


Phe Pro Ser Leu Phe Pro Pro Gly His Gly Pro Leu Val Ser Thr Thr 
                85                  90                  95      


Ala Ala Phe Ala Ala Ala Ile Ser Met Val Val Ala Met Ala Val Tyr 
            100                 105                 110         


Thr Ser Glu Arg Trp Asp Gln Pro Pro His Pro Gln Ile Gln Thr Phe 
        115                 120                 125             


Phe Ser Trp Ser Phe Tyr Leu Gly Trp Val Ser Ala Ile Leu Leu Leu 
    130                 135                 140                 


Cys Thr Gly Ala Leu Ser Leu Gly Ala His Cys Gly Gly Pro Arg Pro 
145                 150                 155                 160 


Gly Tyr Glu Thr Leu 
                165 


<210>  9376
<211>  72
<212>  PRT
<213>  Homo Sapiens

<400>  9376

Thr Gly His Gly Asp Ile Ile Ser Ala Ile Ser Met Val Val Ala Met 
1               5                   10                  15      


Ala Val Tyr Thr Ser Glu Arg Trp Asp Gln Pro Pro His Pro Gln Ile 
            20                  25                  30          


Gln Thr Phe Phe Ser Trp Ser Phe Tyr Leu Gly Trp Val Ser Ala Ile 
        35                  40                  45              


Leu Leu Leu Cys Thr Gly Ala Leu Ser Leu Gly Ala His Cys Gly Gly 
    50                  55                  60                  


Pro Arg Pro Gly Tyr Glu Thr Leu 
65                  70          


<210>  9377
<211>  89
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9377

Xaa Trp Pro Thr Gly His Gly Asp Ile Ile Ser Gly His Gly Pro Leu 
1               5                   10                  15      


Val Ser Thr Thr Ala Ala Phe Ala Ala Ala Ile Ser Met Val Val Ala 
            20                  25                  30          


Met Ala Val Tyr Thr Ser Glu Arg Trp Asp Gln Pro Pro His Pro Gln 
        35                  40                  45              


Ile Gln Thr Phe Phe Ser Trp Ser Phe Tyr Leu Gly Trp Val Ser Ala 
    50                  55                  60                  


Ile Leu Leu Leu Cys Thr Gly Ala Leu Ser Leu Gly Ala His Cys Gly 
65                  70                  75                  80  


Gly Pro Arg Pro Gly Tyr Glu Thr Leu 
                85                  


<210>  9378
<211>  351
<212>  PRT
<213>  Homo Sapiens

<400>  9378

Met Leu Pro Val Trp Phe Thr Ala Asn Leu Asp Ile Val Ala Thr Tyr 
1               5                   10                  15      


Ile Gln Glu Pro Asn Glu Asp Cys Leu Tyr Leu Asn Val Tyr Val Pro 
            20                  25                  30          


Thr Glu Asp Gly Ser Gly Ala Lys Lys Gln Gly Glu Asp Leu Ala Asp 
        35                  40                  45              


Asn Asp Gly Asp Glu Asp Glu Asp Ile Arg Asp Ser Gly Ala Lys Pro 
    50                  55                  60                  


Val Met Val Tyr Ile His Gly Gly Ser Tyr Met Glu Gly Thr Gly Asn 
65                  70                  75                  80  


Met Ile Asp Gly Ser Ile Leu Ala Ser Tyr Gly Asn Val Ile Val Ile 
                85                  90                  95      


Thr Leu Asn Tyr Arg Val Gly Val Leu Gly Phe Leu Ser Thr Gly Asp 
            100                 105                 110         


Gln Ala Ala Lys Gly Asn Tyr Gly Leu Leu Asp Gln Ile Gln Ala Leu 
        115                 120                 125             


Arg Trp Val Ser Glu Asn Ile Ala Phe Phe Gly Gly Asp Pro Arg Arg 
    130                 135                 140                 


Ile Thr Val Phe Gly Ser Gly Ile Gly Ala Ser Cys Val Ser Leu Leu 
145                 150                 155                 160 


Thr Leu Ser His His Ser Glu Gly Leu Phe Gln Arg Ala Ile Ile Gln 
                165                 170                 175     


Ser Gly Ser Ala Leu Ser Ser Trp Ala Val Asn Tyr Gln Pro Val Lys 
            180                 185                 190         


Tyr Thr Ser Leu Leu Ala Asp Lys Val Gly Cys Asn Val Leu Asp Thr 
        195                 200                 205             


Val Asp Met Val Asp Cys Leu Arg Gln Lys Ser Ala Lys Glu Leu Val 
    210                 215                 220                 


Glu Gln Asp Ile Gln Pro Ala Arg Tyr His Val Ala Phe Gly Pro Val 
225                 230                 235                 240 


Ile Asp Gly Asp Val Ile Pro Asp Asp Pro Glu Ile Leu Met Glu Gln 
                245                 250                 255     


Gly Glu Phe Leu Asn Tyr Asp Ile Met Leu Gly Val Asn Gln Gly Glu 
            260                 265                 270         


Gly Leu Lys Phe Val Glu Gly Val Val Asp Pro Glu Asp Gly Val Ser 
        275                 280                 285             


Gly Thr Asp Phe Asp Tyr Ser Val Ser Ile Leu Trp Thr Ile Cys Met 
    290                 295                 300                 


Ala Ile Leu Arg Val Arg Thr Pro Cys Glu Arg Pro Ser Ser Ser Cys 
305                 310                 315                 320 


Ile Gln Thr Gly Gln Thr Val Thr Thr Leu Arg Pro Ala Val Lys His 
                325                 330                 335     


Trp Trp His Ser Ser Leu Thr Thr Ser Gly Trp Ser Pro Gln Trp 
            340                 345                 350     


<210>  9379
<211>  513
<212>  PRT
<213>  Homo Sapiens

<400>  9379

Met Trp Leu Arg Leu Gly Pro Pro Ser Leu Ser Leu Ser Pro Lys Pro 
1               5                   10                  15      


Thr Val Gly Arg Ser Leu Cys Leu Thr Leu Trp Phe Leu Ser Leu Ala 
            20                  25                  30          


Leu Arg Ala Ser Thr Gln Ala Pro Ala Pro Thr Val Asn Thr His Phe 
        35                  40                  45              


Gly Lys Leu Arg Gly Ala Arg Val Pro Leu Pro Ser Glu Ile Leu Gly 
    50                  55                  60                  


Pro Val Asp Gln Tyr Leu Gly Val Pro Tyr Ala Ala Pro Pro Ile Gly 
65                  70                  75                  80  


Glu Lys Arg Phe Leu Pro Pro Glu Pro Pro Pro Ser Trp Ser Gly Ile 
                85                  90                  95      


Arg Asn Ala Thr His Phe Pro Pro Val Cys Pro Gln Asn Ile His Thr 
            100                 105                 110         


Ala Val Pro Glu Val Met Leu Pro Val Trp Phe Thr Ala Asn Leu Asp 
        115                 120                 125             


Ile Val Ala Thr Tyr Ile Gln Glu Pro Asn Glu Asp Cys Leu Tyr Leu 
    130                 135                 140                 


Asn Val Tyr Val Pro Thr Glu Asp Asp Ile Arg Asp Ser Gly Ala Lys 
145                 150                 155                 160 


Pro Val Met Val Tyr Ile His Gly Gly Ser Tyr Met Glu Gly Thr Gly 
                165                 170                 175     


Asn Met Ile Asp Gly Ser Ile Leu Ala Ser Tyr Gly Asn Val Ile Val 
            180                 185                 190         


Ile Thr Leu Asn Tyr Arg Val Gly Val Leu Gly Phe Leu Ser Thr Gly 
        195                 200                 205             


Asp Gln Ala Ala Lys Gly Asn Tyr Gly Leu Leu Asp Gln Ile Gln Ala 
    210                 215                 220                 


Leu Arg Trp Val Ser Glu Asn Ile Ala Phe Phe Gly Gly Asp Pro Arg 
225                 230                 235                 240 


Arg Ile Thr Val Phe Gly Ser Gly Ile Gly Ala Ser Cys Val Ser Leu 
                245                 250                 255     


Leu Thr Leu Ser His His Ser Glu Gly Leu Phe Gln Arg Ala Ile Ile 
            260                 265                 270         


Gln Ser Gly Ser Ala Leu Ser Ser Trp Ala Val Asn Tyr Gln Pro Val 
        275                 280                 285             


Lys Tyr Thr Ser Leu Leu Ala Asp Lys Val Gly Cys Asn Val Leu Asp 
    290                 295                 300                 


Thr Val Asp Met Val Asp Cys Leu Arg Gln Lys Ser Ala Lys Glu Leu 
305                 310                 315                 320 


Val Glu Gln Asp Ile Gln Pro Ala Arg Tyr His Val Ala Phe Gly Pro 
                325                 330                 335     


Val Ile Asp Gly Asp Val Ile Pro Asp Asp Pro Glu Ile Leu Met Glu 
            340                 345                 350         


Gln Gly Glu Phe Leu Asn Tyr Asp Ile Met Leu Gly Val Asn Gln Gly 
        355                 360                 365             


Glu Gly Leu Lys Phe Val Glu Gly Val Val Asp Pro Glu Asp Gly Val 
    370                 375                 380                 


Ser Gly Thr Asp Phe Asp Tyr Ser Val Ser Asn Phe Val Asp Asn Leu 
385                 390                 395                 400 


Tyr Gly Tyr Pro Glu Gly Lys Asp Thr Leu Arg Glu Thr Ile Lys Phe 
                405                 410                 415     


Met Tyr Thr Asp Trp Ala Asp Arg Asp Asn Pro Glu Thr Arg Arg Lys 
            420                 425                 430         


Thr Leu Val Ala Leu Phe Thr Asp His Gln Trp Val Glu Pro Ser Val 
        435                 440                 445             


Val Thr Ala Asp Leu His Ala Arg Tyr Gly Ser Pro Thr Tyr Phe Tyr 
    450                 455                 460                 


Ala Phe Tyr His His Cys Gln Ser Leu Met Lys Pro Ala Trp Ser Asp 
465                 470                 475                 480 


Ala Ala His Gly Asp Glu Val Pro Tyr Val Phe Gly Val Pro Met Val 
                485                 490                 495     


Gly Pro Thr Asp Leu Phe Pro Cys Asn Phe Ser Lys Asn Asp Val Met 
            500                 505                 510         


Leu 
    


<210>  9380
<211>  808
<212>  PRT
<213>  Homo Sapiens

<400>  9380

Met Trp Leu Arg Leu Gly Pro Pro Ser Leu Ser Leu Ser Pro Lys Pro 
1               5                   10                  15      


Thr Val Gly Arg Ser Leu Cys Leu Thr Leu Trp Phe Leu Ser Leu Ala 
            20                  25                  30          


Leu Arg Ala Ser Thr Gln Ala Pro Ala Pro Thr Val Asn Thr His Phe 
        35                  40                  45              


Gly Lys Leu Arg Gly Ala Arg Val Pro Leu Pro Ser Glu Ile Leu Gly 
    50                  55                  60                  


Pro Val Asp Gln Tyr Leu Gly Val Pro Tyr Ala Ala Pro Pro Ile Gly 
65                  70                  75                  80  


Glu Lys Arg Phe Leu Pro Pro Glu Pro Pro Pro Ser Trp Ser Gly Ile 
                85                  90                  95      


Arg Asn Ala Thr His Phe Pro Pro Val Cys Pro Gln Asn Ile His Thr 
            100                 105                 110         


Ala Val Pro Glu Val Met Leu Pro Val Trp Phe Thr Ala Asn Leu Asp 
        115                 120                 125             


Ile Val Ala Thr Tyr Ile Gln Glu Pro Asn Glu Asp Cys Leu Tyr Leu 
    130                 135                 140                 


Asn Val Tyr Val Pro Thr Glu Asp Asp Ile Arg Asp Ser Gly Ala Lys 
145                 150                 155                 160 


Pro Val Met Val Tyr Ile His Gly Gly Ser Tyr Met Glu Gly Thr Gly 
                165                 170                 175     


Asn Met Ile Asp Gly Ser Ile Leu Ala Ser Tyr Gly Asn Val Ile Val 
            180                 185                 190         


Ile Thr Leu Asn Tyr Arg Val Gly Val Leu Gly Phe Leu Ser Thr Gly 
        195                 200                 205             


Asp Gln Ala Ala Lys Gly Asn Tyr Gly Leu Leu Asp Gln Ile Gln Ala 
    210                 215                 220                 


Leu Arg Trp Val Ser Glu Asn Ile Ala Phe Phe Gly Gly Asp Pro Arg 
225                 230                 235                 240 


Arg Ile Thr Val Phe Gly Ser Gly Ile Gly Ala Ser Cys Val Ser Leu 
                245                 250                 255     


Leu Thr Leu Ser His His Ser Glu Gly Leu Phe Gln Arg Ala Ile Ile 
            260                 265                 270         


Gln Ser Gly Ser Ala Leu Ser Ser Trp Ala Val Asn Tyr Gln Pro Val 
        275                 280                 285             


Lys Tyr Thr Ser Leu Leu Ala Asp Lys Val Gly Cys Asn Val Leu Asp 
    290                 295                 300                 


Thr Val Asp Met Val Asp Cys Leu Arg Gln Lys Ser Ala Lys Glu Leu 
305                 310                 315                 320 


Val Glu Gln Asp Ile Gln Pro Ala Arg Tyr His Val Ala Phe Gly Pro 
                325                 330                 335     


Val Ile Asp Gly Asp Val Ile Pro Asp Asp Pro Glu Ile Leu Met Glu 
            340                 345                 350         


Gln Gly Glu Phe Leu Asn Tyr Asp Ile Met Leu Gly Val Asn Gln Gly 
        355                 360                 365             


Glu Gly Leu Lys Phe Val Glu Gly Val Val Asp Pro Glu Asp Gly Val 
    370                 375                 380                 


Ser Gly Thr Asp Phe Asp Tyr Ser Val Ser Asn Phe Val Asp Asn Leu 
385                 390                 395                 400 


Tyr Gly Tyr Pro Glu Gly Lys Asp Thr Leu Arg Glu Thr Ile Lys Phe 
                405                 410                 415     


Met Tyr Thr Asp Trp Ala Asp Arg Asp Asn Pro Glu Thr Arg Arg Lys 
            420                 425                 430         


Thr Leu Val Ala Leu Phe Thr Asp His Gln Trp Val Glu Pro Ser Val 
        435                 440                 445             


Val Thr Ala Asp Leu His Ala Arg Tyr Gly Ser Pro Thr Tyr Phe Tyr 
    450                 455                 460                 


Ala Phe Tyr His His Cys Gln Ser Leu Met Lys Pro Ala Trp Ser Asp 
465                 470                 475                 480 


Ala Ala His Gly Asp Glu Val Pro Tyr Val Phe Gly Val Pro Met Val 
                485                 490                 495     


Gly Pro Thr Asp Leu Phe Pro Cys Asn Phe Ser Lys Asn Asp Val Met 
            500                 505                 510         


Leu Ser Ala Val Val Met Thr Tyr Trp Thr Asn Phe Ala Lys Thr Gly 
        515                 520                 525             


Asp Pro Asn Lys Pro Val Pro Gln Asp Thr Lys Phe Ile His Thr Lys 
    530                 535                 540                 


Ala Asn Arg Phe Glu Glu Val Ala Trp Ser Lys Tyr Asn Pro Arg Asp 
545                 550                 555                 560 


Gln Leu Tyr Leu His Ile Gly Leu Lys Pro Arg Val Arg Asp His Tyr 
                565                 570                 575     


Arg Ala Thr Lys Val Ala Phe Trp Lys His Leu Val Pro His Leu Tyr 
            580                 585                 590         


Asn Leu His Asp Met Phe His Tyr Thr Ser Thr Thr Thr Lys Val Pro 
        595                 600                 605             


Pro Pro Asp Thr Thr His Ser Ser His Ile Thr Arg Arg Pro Asn Gly 
    610                 615                 620                 


Lys Thr Trp Ser Thr Lys Arg Pro Ala Ile Ser Pro Ala Tyr Ser Asn 
625                 630                 635                 640 


Glu Asn Ala Gln Gly Ser Trp Asn Gly Asp Gln Asp Ala Gly Pro Leu 
                645                 650                 655     


Leu Val Glu Asn Pro Arg Asp Tyr Ser Thr Glu Leu Ser Val Thr Ile 
            660                 665                 670         


Ala Val Gly Ala Ser Leu Leu Phe Leu Asn Val Leu Ala Phe Ala Ala 
        675                 680                 685             


Leu Tyr Tyr Arg Lys Asp Lys Arg Arg Gln Glu Pro Leu Arg Gln Pro 
    690                 695                 700                 


Ser Pro Gln Arg Gly Ala Gly Ala Pro Glu Leu Gly Ala Ala Pro Glu 
705                 710                 715                 720 


Glu Glu Leu Ala Ala Leu Gln Leu Gly Pro Thr His His Glu Cys Glu 
                725                 730                 735     


Ala Gly Pro Pro His Asp Thr Leu Arg Leu Thr Ala Leu Pro Asp Tyr 
            740                 745                 750         


Thr Leu Thr Leu Arg Arg Ser Pro Asp Asp Ile Pro Leu Met Thr Pro 
        755                 760                 765             


Asn Thr Ile Thr Met Ile Pro Asn Ser Leu Val Gly Leu Gln Thr Leu 
    770                 775                 780                 


His Pro Tyr Asn Thr Phe Ala Ala Gly Phe Asn Ser Thr Gly Leu Pro 
785                 790                 795                 800 


His Ser His Ser Thr Thr Arg Val 
                805             


<210>  9381
<211>  828
<212>  PRT
<213>  Homo Sapiens

<400>  9381

Met Trp Leu Arg Leu Gly Pro Pro Ser Leu Ser Leu Ser Pro Lys Pro 
1               5                   10                  15      


Thr Val Gly Arg Ser Leu Cys Leu Thr Leu Trp Phe Leu Ser Leu Ala 
            20                  25                  30          


Leu Arg Ala Ser Thr Gln Ala Pro Ala Pro Thr Val Asn Thr His Phe 
        35                  40                  45              


Gly Lys Leu Arg Gly Ala Arg Val Pro Leu Pro Ser Glu Ile Leu Gly 
    50                  55                  60                  


Pro Val Asp Gln Tyr Leu Gly Val Pro Tyr Ala Ala Pro Pro Ile Gly 
65                  70                  75                  80  


Glu Lys Arg Phe Leu Pro Pro Glu Pro Pro Pro Ser Trp Ser Gly Ile 
                85                  90                  95      


Arg Asn Ala Thr His Phe Pro Pro Val Cys Pro Gln Asn Ile His Thr 
            100                 105                 110         


Ala Val Pro Glu Val Met Leu Pro Val Trp Phe Thr Ala Asn Leu Asp 
        115                 120                 125             


Ile Val Ala Thr Tyr Ile Gln Glu Pro Asn Glu Asp Cys Leu Tyr Leu 
    130                 135                 140                 


Asn Val Tyr Val Pro Thr Glu Asp Gly Ser Gly Ala Lys Lys Gln Gly 
145                 150                 155                 160 


Glu Asp Leu Ala Asp Asn Asp Gly Asp Glu Asp Glu Asp Ile Arg Asp 
                165                 170                 175     


Ser Gly Ala Lys Pro Val Met Val Tyr Ile His Gly Gly Ser Tyr Met 
            180                 185                 190         


Glu Gly Thr Gly Asn Met Ile Asp Gly Ser Ile Leu Ala Ser Tyr Gly 
        195                 200                 205             


Asn Val Ile Val Ile Thr Leu Asn Tyr Arg Val Gly Val Leu Gly Phe 
    210                 215                 220                 


Leu Ser Thr Gly Asp Gln Ala Ala Lys Gly Asn Tyr Gly Leu Leu Asp 
225                 230                 235                 240 


Gln Ile Gln Ala Leu Arg Trp Val Ser Glu Asn Ile Ala Phe Phe Gly 
                245                 250                 255     


Gly Asp Pro Arg Arg Ile Thr Val Phe Gly Ser Gly Ile Gly Ala Ser 
            260                 265                 270         


Cys Val Ser Leu Leu Thr Leu Ser His His Ser Glu Gly Leu Phe Gln 
        275                 280                 285             


Arg Ala Ile Ile Gln Ser Gly Ser Ala Leu Ser Ser Trp Ala Val Asn 
    290                 295                 300                 


Tyr Gln Pro Val Lys Tyr Thr Ser Leu Leu Ala Asp Lys Val Gly Cys 
305                 310                 315                 320 


Asn Val Leu Asp Thr Val Asp Met Val Asp Cys Leu Arg Gln Lys Ser 
                325                 330                 335     


Ala Lys Glu Leu Val Glu Gln Asp Ile Gln Pro Ala Arg Tyr His Val 
            340                 345                 350         


Ala Phe Gly Pro Val Ile Asp Gly Asp Val Ile Pro Asp Asp Pro Glu 
        355                 360                 365             


Ile Leu Met Glu Gln Gly Glu Phe Leu Asn Tyr Asp Ile Met Leu Gly 
    370                 375                 380                 


Val Asn Gln Gly Glu Gly Leu Lys Phe Val Glu Gly Val Val Asp Pro 
385                 390                 395                 400 


Glu Asp Gly Val Ser Gly Thr Asp Phe Asp Tyr Ser Val Ser Asn Phe 
                405                 410                 415     


Val Asp Asn Leu Tyr Gly Tyr Pro Glu Gly Lys Asp Thr Leu Arg Glu 
            420                 425                 430         


Thr Ile Lys Phe Met Tyr Thr Asp Trp Ala Asp Arg Asp Asn Pro Glu 
        435                 440                 445             


Thr Arg Arg Lys Thr Leu Val Ala Leu Phe Thr Asp His Gln Trp Val 
    450                 455                 460                 


Glu Pro Ser Val Val Thr Ala Asp Leu His Ala Arg Tyr Gly Ser Pro 
465                 470                 475                 480 


Thr Tyr Phe Tyr Ala Phe Tyr His His Cys Gln Ser Leu Met Lys Pro 
                485                 490                 495     


Ala Trp Ser Asp Ala Ala His Gly Asp Glu Val Pro Tyr Val Phe Gly 
            500                 505                 510         


Val Pro Met Val Gly Pro Thr Asp Leu Phe Pro Cys Asn Phe Ser Lys 
        515                 520                 525             


Asn Asp Val Met Leu Ser Ala Val Val Met Thr Tyr Trp Thr Asn Phe 
    530                 535                 540                 


Ala Lys Thr Gly Asp Pro Asn Lys Pro Val Pro Gln Asp Thr Lys Phe 
545                 550                 555                 560 


Ile His Thr Lys Ala Asn Arg Phe Glu Glu Val Ala Trp Ser Lys Tyr 
                565                 570                 575     


Asn Pro Arg Asp Gln Leu Tyr Leu His Ile Gly Leu Lys Pro Arg Val 
            580                 585                 590         


Arg Asp His Tyr Arg Ala Thr Lys Val Ala Phe Trp Lys His Leu Val 
        595                 600                 605             


Pro His Leu Tyr Asn Leu His Asp Met Phe His Tyr Thr Ser Thr Thr 
    610                 615                 620                 


Thr Lys Val Pro Pro Pro Asp Thr Thr His Ser Ser His Ile Thr Arg 
625                 630                 635                 640 


Arg Pro Asn Gly Lys Thr Trp Ser Thr Lys Arg Pro Ala Ile Ser Pro 
                645                 650                 655     


Ala Tyr Ser Asn Glu Asn Ala Gln Gly Ser Trp Asn Gly Asp Gln Asp 
            660                 665                 670         


Ala Gly Pro Leu Leu Val Glu Asn Pro Arg Asp Tyr Ser Thr Glu Leu 
        675                 680                 685             


Ser Val Thr Ile Ala Val Gly Ala Ser Leu Leu Phe Leu Asn Val Leu 
    690                 695                 700                 


Ala Phe Ala Ala Leu Tyr Tyr Arg Lys Asp Lys Arg Arg Gln Glu Pro 
705                 710                 715                 720 


Leu Arg Gln Pro Ser Pro Gln Arg Gly Ala Gly Ala Pro Glu Leu Gly 
                725                 730                 735     


Ala Ala Pro Glu Glu Glu Leu Ala Ala Leu Gln Leu Gly Pro Thr His 
            740                 745                 750         


His Glu Cys Glu Ala Gly Pro Pro His Asp Thr Leu Arg Leu Thr Ala 
        755                 760                 765             


Leu Pro Asp Tyr Thr Leu Thr Leu Arg Arg Ser Pro Asp Asp Ile Pro 
    770                 775                 780                 


Leu Met Thr Pro Asn Thr Ile Thr Met Ile Pro Asn Ser Leu Val Gly 
785                 790                 795                 800 


Leu Gln Thr Leu His Pro Tyr Asn Thr Phe Ala Ala Gly Phe Asn Ser 
                805                 810                 815     


Thr Gly Leu Pro His Ser His Ser Thr Thr Arg Val 
            820                 825             


<210>  9382
<211>  848
<212>  PRT
<213>  Homo Sapiens

<400>  9382

Met Trp Leu Arg Leu Gly Pro Pro Ser Leu Ser Leu Ser Pro Lys Pro 
1               5                   10                  15      


Thr Val Gly Arg Ser Leu Cys Leu Thr Leu Trp Phe Leu Ser Leu Ala 
            20                  25                  30          


Leu Arg Ala Ser Thr Gln Ala Pro Ala Pro Thr Val Asn Thr His Phe 
        35                  40                  45              


Gly Lys Leu Arg Gly Ala Arg Val Pro Leu Pro Ser Glu Ile Leu Gly 
    50                  55                  60                  


Pro Val Asp Gln Tyr Leu Gly Val Pro Tyr Ala Ala Pro Pro Ile Gly 
65                  70                  75                  80  


Glu Lys Arg Phe Leu Pro Pro Glu Pro Pro Pro Ser Trp Ser Gly Ile 
                85                  90                  95      


Arg Asn Ala Thr His Phe Pro Pro Val Cys Pro Gln Asn Ile His Thr 
            100                 105                 110         


Ala Val Pro Glu Val Met Leu Pro Val Trp Phe Thr Ala Asn Leu Asp 
        115                 120                 125             


Ile Val Ala Thr Tyr Ile Gln Glu Pro Asn Glu Asp Cys Leu Tyr Leu 
    130                 135                 140                 


Asn Val Tyr Val Pro Thr Glu Asp Val Lys Arg Ile Ser Lys Glu Cys 
145                 150                 155                 160 


Ala Arg Lys Pro Asn Lys Lys Ile Cys Arg Lys Gly Gly Ser Gly Ala 
                165                 170                 175     


Lys Lys Gln Gly Glu Asp Leu Ala Asp Asn Asp Gly Asp Glu Asp Glu 
            180                 185                 190         


Asp Ile Arg Asp Ser Gly Ala Lys Pro Val Met Val Tyr Ile His Gly 
        195                 200                 205             


Gly Ser Tyr Met Glu Gly Thr Gly Asn Met Ile Asp Gly Ser Ile Leu 
    210                 215                 220                 


Ala Ser Tyr Gly Asn Val Ile Val Ile Thr Leu Asn Tyr Arg Val Gly 
225                 230                 235                 240 


Val Leu Gly Phe Leu Ser Thr Gly Asp Gln Ala Ala Lys Gly Asn Tyr 
                245                 250                 255     


Gly Leu Leu Asp Gln Ile Gln Ala Leu Arg Trp Val Ser Glu Asn Ile 
            260                 265                 270         


Ala Phe Phe Gly Gly Asp Pro Arg Arg Ile Thr Val Phe Gly Ser Gly 
        275                 280                 285             


Ile Gly Ala Ser Cys Val Ser Leu Leu Thr Leu Ser His His Ser Glu 
    290                 295                 300                 


Gly Leu Phe Gln Arg Ala Ile Ile Gln Ser Gly Ser Ala Leu Ser Ser 
305                 310                 315                 320 


Trp Ala Val Asn Tyr Gln Pro Val Lys Tyr Thr Ser Leu Leu Ala Asp 
                325                 330                 335     


Lys Val Gly Cys Asn Val Leu Asp Thr Val Asp Met Val Asp Cys Leu 
            340                 345                 350         


Arg Gln Lys Ser Ala Lys Glu Leu Val Glu Gln Asp Ile Gln Pro Ala 
        355                 360                 365             


Arg Tyr His Val Ala Phe Gly Pro Val Ile Asp Gly Asp Val Ile Pro 
    370                 375                 380                 


Asp Asp Pro Glu Ile Leu Met Glu Gln Gly Glu Phe Leu Asn Tyr Asp 
385                 390                 395                 400 


Ile Met Leu Gly Val Asn Gln Gly Glu Gly Leu Lys Phe Val Glu Gly 
                405                 410                 415     


Val Val Asp Pro Glu Asp Gly Val Ser Gly Thr Asp Phe Asp Tyr Ser 
            420                 425                 430         


Val Ser Asn Phe Val Asp Asn Leu Tyr Gly Tyr Pro Glu Gly Lys Asp 
        435                 440                 445             


Thr Leu Arg Glu Thr Ile Lys Phe Met Tyr Thr Asp Trp Ala Asp Arg 
    450                 455                 460                 


Asp Asn Pro Glu Thr Arg Arg Lys Thr Leu Val Ala Leu Phe Thr Asp 
465                 470                 475                 480 


His Gln Trp Val Glu Pro Ser Val Val Thr Ala Asp Leu His Ala Arg 
                485                 490                 495     


Tyr Gly Ser Pro Thr Tyr Phe Tyr Ala Phe Tyr His His Cys Gln Ser 
            500                 505                 510         


Leu Met Lys Pro Ala Trp Ser Asp Ala Ala His Gly Asp Glu Val Pro 
        515                 520                 525             


Tyr Val Phe Gly Val Pro Met Val Gly Pro Thr Asp Leu Phe Pro Cys 
    530                 535                 540                 


Asn Phe Ser Lys Asn Asp Val Met Leu Ser Ala Val Val Met Thr Tyr 
545                 550                 555                 560 


Trp Thr Asn Phe Ala Lys Thr Gly Asp Pro Asn Lys Pro Val Pro Gln 
                565                 570                 575     


Asp Thr Lys Phe Ile His Thr Lys Ala Asn Arg Phe Glu Glu Val Ala 
            580                 585                 590         


Trp Ser Lys Tyr Asn Pro Arg Asp Gln Leu Tyr Leu His Ile Gly Leu 
        595                 600                 605             


Lys Pro Arg Val Arg Asp His Tyr Arg Ala Thr Lys Val Ala Phe Trp 
    610                 615                 620                 


Lys His Leu Val Pro His Leu Tyr Asn Leu His Asp Met Phe His Tyr 
625                 630                 635                 640 


Thr Ser Thr Thr Thr Lys Val Pro Pro Pro Asp Thr Thr His Ser Ser 
                645                 650                 655     


His Ile Thr Arg Arg Pro Asn Gly Lys Thr Trp Ser Thr Lys Arg Pro 
            660                 665                 670         


Ala Ile Ser Pro Ala Tyr Ser Asn Glu Asn Ala Gln Gly Ser Trp Asn 
        675                 680                 685             


Gly Asp Gln Asp Ala Gly Pro Leu Leu Val Glu Asn Pro Arg Asp Tyr 
    690                 695                 700                 


Ser Thr Glu Leu Ser Val Thr Ile Ala Val Gly Ala Ser Leu Leu Phe 
705                 710                 715                 720 


Leu Asn Val Leu Ala Phe Ala Ala Leu Tyr Tyr Arg Lys Asp Lys Arg 
                725                 730                 735     


Arg Gln Glu Pro Leu Arg Gln Pro Ser Pro Gln Arg Gly Ala Gly Ala 
            740                 745                 750         


Pro Glu Leu Gly Ala Ala Pro Glu Glu Glu Leu Ala Ala Leu Gln Leu 
        755                 760                 765             


Gly Pro Thr His His Glu Cys Glu Ala Gly Pro Pro His Asp Thr Leu 
    770                 775                 780                 


Arg Leu Thr Ala Leu Pro Asp Tyr Thr Leu Thr Leu Arg Arg Ser Pro 
785                 790                 795                 800 


Asp Asp Ile Pro Leu Met Thr Pro Asn Thr Ile Thr Met Ile Pro Asn 
                805                 810                 815     


Ser Leu Val Gly Leu Gln Thr Leu His Pro Tyr Asn Thr Phe Ala Ala 
            820                 825                 830         


Gly Phe Asn Ser Thr Gly Leu Pro His Ser His Ser Thr Thr Arg Val 
        835                 840                 845             


<210>  9383
<211>  33
<212>  PRT
<213>  Homo Sapiens

<400>  9383

Met Leu Arg Pro Gln Gly Leu Leu Trp Leu Pro Leu Leu Phe Thr Ser 
1               5                   10                  15      


Val Cys Val Met Leu Asn Ser Asn Val Leu Leu Trp Ile Thr Ala Leu 
            20                  25                  30          


Ala 
    


<210>  9384
<211>  816
<212>  PRT
<213>  Homo Sapiens

<400>  9384

Met Leu Arg Pro Gln Gly Leu Leu Trp Leu Pro Leu Leu Phe Thr Ser 
1               5                   10                  15      


Val Cys Val Met Leu Asn Ser Asn Val Leu Leu Trp Ile Thr Ala Leu 
            20                  25                  30          


Ala Ile Lys Phe Thr Leu Ile Asp Ser Gln Ala Gln Tyr Pro Val Val 
        35                  40                  45              


Asn Thr Asn Tyr Gly Lys Ile Gln Gly Leu Arg Thr Pro Leu Pro Ser 
    50                  55                  60                  


Glu Ile Leu Gly Pro Val Glu Gln Tyr Leu Gly Val Pro Tyr Ala Ser 
65                  70                  75                  80  


Pro Pro Thr Gly Glu Arg Arg Phe Gln Pro Pro Glu Ser Pro Ser Ser 
                85                  90                  95      


Trp Thr Gly Ile Arg Asn Ala Thr Gln Phe Ser Ala Val Cys Pro Gln 
            100                 105                 110         


His Leu Asp Glu Arg Phe Leu Leu His Asp Met Leu Pro Ile Trp Phe 
        115                 120                 125             


Thr Thr Ser Leu Asp Thr Leu Met Thr Tyr Val Gln Asp Gln Asn Glu 
    130                 135                 140                 


Asp Cys Leu Tyr Leu Asn Ile Tyr Val Pro Met Glu Asp Asp Ile His 
145                 150                 155                 160 


Glu Gln Asn Ser Lys Lys Pro Val Met Val Tyr Ile His Gly Gly Ser 
                165                 170                 175     


Tyr Met Glu Gly Thr Gly Asn Met Ile Asp Gly Ser Ile Leu Ala Ser 
            180                 185                 190         


Tyr Gly Asn Val Ile Val Ile Thr Ile Asn Tyr Arg Leu Gly Ile Leu 
        195                 200                 205             


Gly Phe Leu Ser Thr Gly Asp Gln Ala Ala Lys Gly Asn Tyr Gly Leu 
    210                 215                 220                 


Leu Asp Gln Ile Gln Ala Leu Arg Trp Ile Glu Glu Asn Val Gly Ala 
225                 230                 235                 240 


Phe Gly Gly Asp Pro Lys Arg Val Thr Ile Phe Gly Ser Gly Ala Gly 
                245                 250                 255     


Ala Ser Cys Val Ser Leu Leu Thr Leu Ser His Tyr Ser Glu Gly Leu 
            260                 265                 270         


Phe Gln Lys Ala Ile Ile Gln Ser Gly Thr Ala Leu Ser Ser Trp Ala 
        275                 280                 285             


Val Asn Tyr Gln Pro Ala Lys Tyr Thr Arg Ile Leu Ala Asp Lys Val 
    290                 295                 300                 


Gly Cys Asn Met Leu Asp Thr Thr Asp Met Val Glu Cys Leu Lys Asn 
305                 310                 315                 320 


Lys Asn Tyr Lys Glu Leu Ile Gln Gln Thr Ile Thr Pro Ala Thr Tyr 
                325                 330                 335     


His Ile Ala Phe Gly Pro Val Ile Asp Gly Asp Val Ile Pro Asp Asp 
            340                 345                 350         


Pro Gln Ile Leu Met Glu Gln Gly Glu Phe Leu Asn Tyr Asp Ile Met 
        355                 360                 365             


Leu Gly Val Asn Gln Gly Glu Gly Leu Lys Phe Val Asp Gly Ile Val 
    370                 375                 380                 


Asp Asn Glu Asp Gly Val Thr Pro Asn Asp Phe Asp Phe Ser Val Ser 
385                 390                 395                 400 


Asn Phe Val Asp Asn Leu Tyr Gly Tyr Pro Glu Gly Lys Asp Thr Leu 
                405                 410                 415     


Arg Glu Thr Ile Lys Phe Met Tyr Thr Asp Trp Ala Asp Lys Glu Asn 
            420                 425                 430         


Pro Glu Thr Arg Arg Lys Thr Leu Val Ala Leu Phe Thr Asp His Gln 
        435                 440                 445             


Trp Val Ala Pro Ala Val Ala Thr Ala Asp Leu His Ala Gln Tyr Gly 
    450                 455                 460                 


Ser Pro Thr Tyr Phe Tyr Ala Phe Tyr His His Cys Gln Ser Glu Met 
465                 470                 475                 480 


Lys Pro Ser Trp Ala Asp Ser Ala His Gly Asp Glu Val Pro Tyr Val 
                485                 490                 495     


Phe Gly Ile Pro Met Ile Gly Pro Thr Glu Leu Phe Ser Cys Asn Phe 
            500                 505                 510         


Ser Lys Asn Asp Val Met Leu Ser Ala Val Val Met Thr Tyr Trp Thr 
        515                 520                 525             


Asn Phe Ala Lys Thr Gly Asp Pro Asn Gln Pro Val Pro Gln Asp Thr 
    530                 535                 540                 


Lys Phe Ile His Thr Lys Pro Asn Arg Phe Glu Glu Val Ala Trp Ser 
545                 550                 555                 560 


Lys Tyr Asn Pro Lys Asp Gln Leu Tyr Leu His Ile Gly Leu Lys Pro 
                565                 570                 575     


Arg Val Arg Asp His Tyr Arg Ala Thr Lys Val Ala Phe Trp Leu Glu 
            580                 585                 590         


Leu Val Pro His Leu His Asn Leu Asn Glu Ile Phe Gln Tyr Val Ser 
        595                 600                 605             


Thr Thr Thr Lys Val Pro Pro Pro Asp Met Thr Ser Phe Pro Tyr Gly 
    610                 615                 620                 


Thr Arg Arg Ser Pro Ala Lys Ile Trp Pro Thr Thr Lys Arg Pro Ala 
625                 630                 635                 640 


Ile Thr Pro Ala Asn Asn Pro Lys His Ser Lys Asp Pro His Lys Thr 
                645                 650                 655     


Gly Pro Glu Asp Thr Thr Val Leu Ile Glu Thr Lys Arg Asp Tyr Ser 
            660                 665                 670         


Thr Glu Leu Ser Val Thr Ile Ala Val Gly Ala Ser Leu Leu Phe Leu 
        675                 680                 685             


Asn Ile Leu Ala Phe Ala Ala Leu Tyr Tyr Lys Lys Asp Lys Arg Arg 
    690                 695                 700                 


His Glu Thr His Arg His Pro Ser Pro Gln Arg Asn Thr Thr Asn Asp 
705                 710                 715                 720 


Ile Thr His Ile Gln Asn Glu Glu Ile Met Ser Leu Gln Met Lys Gln 
                725                 730                 735     


Leu Glu His Asp His Glu Cys Glu Ser Leu Gln Ala His Asp Thr Leu 
            740                 745                 750         


Arg Leu Thr Cys Pro Pro Asp Tyr Thr Leu Thr Leu Arg Arg Ser Pro 
        755                 760                 765             


Asp Asp Ile Pro Phe Met Thr Pro Asn Thr Ile Thr Met Ile Pro Asn 
    770                 775                 780                 


Thr Leu Met Gly Met Gln Pro Leu His Thr Phe Lys Thr Phe Ser Gly 
785                 790                 795                 800 


Gly Gln Asn Ser Thr Asn Leu Pro His Gly His Ser Thr Thr Arg Val 
                805                 810                 815     


<210>  9385
<211>  816
<212>  PRT
<213>  Homo Sapiens

<400>  9385

Met Leu Arg Pro Gln Gly Leu Leu Trp Leu Pro Leu Leu Phe Thr Ser 
1               5                   10                  15      


Val Cys Val Met Leu Asn Ser Asn Val Leu Leu Trp Ile Thr Ala Leu 
            20                  25                  30          


Ala Ile Lys Phe Thr Leu Ile Asp Ser Gln Ala Gln Tyr Pro Val Val 
        35                  40                  45              


Asn Thr Asn Tyr Gly Lys Ile Gln Gly Leu Arg Thr Pro Leu Pro Ser 
    50                  55                  60                  


Glu Ile Leu Gly Pro Val Glu Gln Tyr Leu Gly Val Pro Tyr Ala Ser 
65                  70                  75                  80  


Pro Pro Thr Gly Glu Arg Arg Phe Gln Pro Pro Glu Ser Pro Ser Ser 
                85                  90                  95      


Trp Thr Gly Ile Arg Asn Ala Thr Gln Phe Ser Ala Val Cys Pro Gln 
            100                 105                 110         


His Leu Asp Glu Arg Phe Leu Leu His Asp Met Leu Pro Ile Trp Phe 
        115                 120                 125             


Thr Thr Ser Leu Asp Thr Leu Met Thr Tyr Val Gln Asp Gln Asn Glu 
    130                 135                 140                 


Asp Cys Leu Tyr Leu Asn Ile Tyr Val Pro Met Glu Asp Asp Ile His 
145                 150                 155                 160 


Glu Gln Asn Ser Lys Lys Pro Val Met Val Tyr Ile His Gly Gly Ser 
                165                 170                 175     


Tyr Met Glu Gly Thr Gly Asn Met Ile Asp Gly Ser Ile Leu Ala Ser 
            180                 185                 190         


Tyr Gly Asn Val Ile Val Ile Thr Ile Asn Tyr Arg Leu Gly Ile Leu 
        195                 200                 205             


Gly Phe Leu Ser Thr Gly Asp Gln Ala Ala Lys Gly Asn Tyr Gly Leu 
    210                 215                 220                 


Leu Asp Gln Ile Gln Ala Leu Arg Trp Ile Glu Glu Asn Val Gly Ala 
225                 230                 235                 240 


Phe Gly Gly Asp Pro Lys Arg Val Thr Ile Phe Gly Ser Gly Ala Gly 
                245                 250                 255     


Ala Ser Cys Val Ser Leu Leu Thr Leu Ser His Tyr Ser Glu Gly Leu 
            260                 265                 270         


Phe Gln Lys Ala Ile Ile Gln Ser Gly Thr Ala Leu Ser Ser Trp Ala 
        275                 280                 285             


Val Asn Tyr Gln Pro Ala Lys Tyr Thr Arg Ile Leu Ala Asp Lys Val 
    290                 295                 300                 


Gly Cys Asn Met Leu Asp Thr Thr Asp Met Val Glu Cys Leu Lys Asn 
305                 310                 315                 320 


Lys Asn Tyr Lys Glu Leu Ile Gln Gln Thr Ile Thr Pro Ala Thr Tyr 
                325                 330                 335     


His Ile Ala Phe Gly Pro Val Ile Asp Gly Asp Val Ile Pro Asp Asp 
            340                 345                 350         


Pro Gln Ile Leu Met Glu Gln Gly Glu Phe Leu Asn Tyr Asp Ile Met 
        355                 360                 365             


Leu Gly Val Asn Gln Gly Glu Gly Leu Lys Phe Val Asp Gly Ile Val 
    370                 375                 380                 


Asp Asn Glu Asp Gly Val Thr Pro Asn Asp Phe Asp Phe Ser Val Ser 
385                 390                 395                 400 


Asn Phe Val Asp Asn Leu Tyr Gly Tyr Pro Glu Gly Lys Asp Thr Leu 
                405                 410                 415     


Arg Glu Thr Ile Lys Phe Met Tyr Thr Asp Trp Ala Asp Lys Glu Asn 
            420                 425                 430         


Pro Glu Thr Arg Arg Lys Thr Leu Val Ala Leu Phe Thr Asp His Gln 
        435                 440                 445             


Trp Val Ala Pro Ala Val Ala Thr Ala Asp Leu His Ala Gln Tyr Gly 
    450                 455                 460                 


Ser Pro Thr Tyr Phe Tyr Ala Phe Tyr His His Cys Gln Ser Glu Met 
465                 470                 475                 480 


Lys Pro Ser Trp Ala Asp Ser Ala His Gly Asp Glu Val Pro Tyr Val 
                485                 490                 495     


Phe Gly Ile Pro Met Ile Gly Pro Thr Glu Leu Phe Ser Cys Asn Phe 
            500                 505                 510         


Ser Lys Asn Asp Val Met Leu Ser Ala Val Val Met Thr Tyr Trp Thr 
        515                 520                 525             


Asn Phe Ala Lys Thr Gly Asp Pro Asn Gln Pro Val Pro Gln Asp Thr 
    530                 535                 540                 


Lys Phe Ile His Thr Lys Pro Asn Arg Phe Glu Glu Val Ala Trp Ser 
545                 550                 555                 560 


Lys Tyr Asn Pro Lys Asp Gln Leu Tyr Leu His Ile Gly Leu Lys Pro 
                565                 570                 575     


Arg Val Arg Asp His Tyr Arg Ala Thr Lys Val Ala Phe Trp Leu Glu 
            580                 585                 590         


Leu Val Pro His Leu His Asn Leu Asn Glu Ile Phe Gln Tyr Val Ser 
        595                 600                 605             


Thr Thr Thr Lys Val Pro Pro Pro Asp Met Thr Ser Phe Pro Tyr Gly 
    610                 615                 620                 


Thr Arg Arg Ser Pro Ala Lys Ile Trp Pro Thr Thr Lys Arg Pro Ala 
625                 630                 635                 640 


Ile Thr Pro Ala Asn Asn Pro Lys His Ser Lys Asp Pro His Lys Thr 
                645                 650                 655     


Gly Pro Glu Asp Thr Thr Val Leu Ile Glu Thr Lys Arg Asp Tyr Ser 
            660                 665                 670         


Thr Glu Leu Ser Val Thr Ile Ala Val Gly Ala Ser Leu Leu Phe Leu 
        675                 680                 685             


Asn Ile Leu Ala Phe Ala Ala Leu Tyr Tyr Lys Lys Asp Lys Arg Arg 
    690                 695                 700                 


His Glu Thr His Arg His Pro Ser Pro Gln Arg Asn Thr Thr Asn Asp 
705                 710                 715                 720 


Ile Thr His Ile Gln Asn Glu Glu Ile Met Ser Leu Gln Met Lys Gln 
                725                 730                 735     


Leu Glu His Asp His Glu Cys Glu Ser Leu Gln Ala His Asp Thr Leu 
            740                 745                 750         


Arg Leu Thr Cys Pro Pro Asp Tyr Thr Leu Thr Leu Arg Arg Ser Pro 
        755                 760                 765             


Asp Asp Ile Pro Phe Met Thr Pro Asn Thr Ile Thr Met Ile Pro Asn 
    770                 775                 780                 


Thr Leu Met Gly Met Gln Pro Leu His Thr Phe Lys Thr Phe Ser Gly 
785                 790                 795                 800 


Gly Gln Asn Ser Thr Asn Leu Pro His Gly His Ser Thr Thr Arg Val 
                805                 810                 815     


<210>  9386
<211>  873
<212>  PRT
<213>  Homo Sapiens

<400>  9386

Met Leu Arg Pro Gln Gly Leu Leu Trp Leu Pro Leu Leu Phe Thr Ser 
1               5                   10                  15      


Val Cys Val Met Leu Asn Ser Asn Val Leu Leu Trp Ile Thr Ala Leu 
            20                  25                  30          


Ala Ile Lys Phe Thr Leu Ile Asp Ser Gln Ala Gln Tyr Pro Val Val 
        35                  40                  45              


Asn Thr Asn Tyr Gly Lys Ile Gln Gly Leu Arg Thr Pro Leu Pro Ser 
    50                  55                  60                  


Glu Ile Leu Gly Pro Val Glu Gln Tyr Leu Gly Val Pro Tyr Ala Ser 
65                  70                  75                  80  


Pro Pro Thr Gly Glu Arg Arg Phe Gln Pro Pro Glu Ser Pro Ser Ser 
                85                  90                  95      


Trp Thr Gly Ile Arg Asn Ala Thr Gln Phe Ser Ala Val Cys Pro Gln 
            100                 105                 110         


His Leu Asp Glu Arg Phe Leu Leu His Asp Met Leu Pro Ile Trp Phe 
        115                 120                 125             


Thr Thr Ser Leu Asp Thr Leu Met Thr Tyr Val Gln Asp Gln Asn Glu 
    130                 135                 140                 


Asp Cys Leu Tyr Leu Asn Ile Tyr Val Pro Met Glu Asp Gly Thr Asn 
145                 150                 155                 160 


Ile Lys Arg Asn Ala Asp Asp Ile Thr Ser Asn Asp His Gly Glu Asp 
                165                 170                 175     


Lys Asp Ile His Glu Gln Asn Ser Lys Lys Pro Val Met Val Tyr Ile 
            180                 185                 190         


His Gly Gly Ser Tyr Met Glu Gly Thr Gly Asn Met Ile Asp Gly Ser 
        195                 200                 205             


Ile Leu Ala Ser Tyr Gly Asn Val Ile Val Ile Thr Ile Asn Tyr Arg 
    210                 215                 220                 


Leu Gly Ile Leu Ala Gln Asn Thr Leu Ala His Gly Asn Cys Lys His 
225                 230                 235                 240 


Arg Cys Gln Leu His Leu Gln Ala Pro Arg Asp Cys Lys Ser Ala Tyr 
                245                 250                 255     


Pro Phe Arg Asn Glu Asp Glu Ile Arg Gly Phe Leu Ser Thr Gly Asp 
            260                 265                 270         


Gln Ala Ala Lys Gly Asn Tyr Gly Leu Leu Asp Gln Ile Gln Ala Leu 
        275                 280                 285             


Arg Trp Ile Glu Glu Asn Val Gly Ala Phe Gly Gly Asp Pro Lys Arg 
    290                 295                 300                 


Val Thr Ile Phe Gly Ser Gly Ala Gly Ala Ser Cys Val Ser Leu Leu 
305                 310                 315                 320 


Thr Leu Ser His Tyr Ser Glu Gly Leu Phe Gln Lys Ala Ile Ile Gln 
                325                 330                 335     


Ser Gly Thr Ala Leu Ser Ser Trp Ala Val Asn Tyr Gln Pro Ala Lys 
            340                 345                 350         


Tyr Thr Arg Ile Leu Ala Asp Lys Val Gly Cys Asn Met Leu Asp Thr 
        355                 360                 365             


Thr Asp Met Val Glu Cys Leu Lys Asn Lys Asn Tyr Lys Glu Leu Ile 
    370                 375                 380                 


Gln Gln Thr Ile Thr Pro Ala Thr Tyr His Ile Ala Phe Gly Pro Val 
385                 390                 395                 400 


Ile Asp Gly Asp Val Ile Pro Asp Asp Pro Gln Ile Leu Met Glu Gln 
                405                 410                 415     


Gly Glu Phe Leu Asn Tyr Asp Ile Met Leu Gly Val Asn Gln Gly Glu 
            420                 425                 430         


Gly Leu Lys Phe Val Asp Gly Ile Val Asp Asn Glu Asp Gly Val Thr 
        435                 440                 445             


Pro Asn Asp Phe Asp Phe Ser Val Ser Asn Phe Val Asp Asn Leu Tyr 
    450                 455                 460                 


Gly Tyr Pro Glu Gly Lys Asp Thr Leu Arg Glu Thr Ile Lys Phe Met 
465                 470                 475                 480 


Tyr Thr Asp Trp Ala Asp Lys Glu Asn Pro Glu Thr Arg Arg Lys Thr 
                485                 490                 495     


Leu Val Ala Leu Phe Thr Asp His Gln Trp Val Ala Pro Ala Val Ala 
            500                 505                 510         


Thr Ala Asp Leu His Ala Gln Tyr Gly Ser Pro Thr Tyr Phe Tyr Ala 
        515                 520                 525             


Phe Tyr His His Cys Gln Ser Glu Met Lys Pro Ser Trp Ala Asp Ser 
    530                 535                 540                 


Ala His Gly Asp Glu Val Pro Tyr Val Phe Gly Ile Pro Met Ile Gly 
545                 550                 555                 560 


Pro Thr Glu Leu Phe Ser Cys Asn Phe Ser Lys Asn Asp Val Met Leu 
                565                 570                 575     


Ser Ala Val Val Met Thr Tyr Trp Thr Asn Phe Ala Lys Thr Gly Asp 
            580                 585                 590         


Pro Asn Gln Pro Val Pro Gln Asp Thr Lys Phe Ile His Thr Lys Pro 
        595                 600                 605             


Asn Arg Phe Glu Glu Val Ala Trp Ser Lys Tyr Asn Pro Lys Asp Gln 
    610                 615                 620                 


Leu Tyr Leu His Ile Gly Leu Lys Pro Arg Val Arg Asp His Tyr Arg 
625                 630                 635                 640 


Ala Thr Lys Val Ala Phe Trp Leu Glu Leu Val Pro His Leu His Asn 
                645                 650                 655     


Leu Asn Glu Ile Phe Gln Tyr Val Ser Thr Thr Thr Lys Val Pro Pro 
            660                 665                 670         


Pro Asp Met Thr Ser Phe Pro Tyr Gly Thr Arg Arg Ser Pro Ala Lys 
        675                 680                 685             


Ile Trp Pro Thr Thr Lys Arg Pro Ala Ile Thr Pro Ala Asn Asn Pro 
    690                 695                 700                 


Lys His Ser Lys Asp Pro His Lys Thr Gly Pro Glu Asp Thr Thr Val 
705                 710                 715                 720 


Leu Ile Glu Thr Lys Arg Asp Tyr Ser Thr Glu Leu Ser Val Thr Ile 
                725                 730                 735     


Ala Val Gly Ala Ser Leu Leu Phe Leu Asn Ile Leu Ala Phe Ala Ala 
            740                 745                 750         


Leu Tyr Tyr Lys Lys Asp Lys Arg Arg His Glu Thr His Arg His Pro 
        755                 760                 765             


Ser Pro Gln Arg Asn Thr Thr Asn Asp Ile Thr His Ile Gln Asn Glu 
    770                 775                 780                 


Glu Ile Met Ser Leu Gln Met Lys Gln Leu Glu His Asp His Glu Cys 
785                 790                 795                 800 


Glu Ser Leu Gln Ala His Asp Thr Leu Arg Leu Thr Cys Pro Pro Asp 
                805                 810                 815     


Tyr Thr Leu Thr Leu Arg Arg Ser Pro Asp Asp Ile Pro Phe Met Thr 
            820                 825                 830         


Pro Asn Thr Ile Thr Met Ile Pro Asn Thr Leu Met Gly Met Gln Pro 
        835                 840                 845             


Leu His Thr Phe Lys Thr Phe Ser Gly Gly Gln Asn Ser Thr Asn Leu 
    850                 855                 860                 


Pro His Gly His Ser Thr Thr Arg Val 
865                 870             


<210>  9387
<211>  836
<212>  PRT
<213>  Homo Sapiens

<400>  9387

Met Leu Arg Pro Gln Gly Leu Leu Trp Leu Pro Leu Leu Phe Thr Ser 
1               5                   10                  15      


Val Cys Val Met Leu Asn Ser Asn Val Leu Leu Trp Ile Thr Ala Leu 
            20                  25                  30          


Ala Ile Lys Phe Thr Leu Ile Asp Ser Gln Ala Gln Tyr Pro Val Val 
        35                  40                  45              


Asn Thr Asn Tyr Gly Lys Ile Gln Gly Leu Arg Thr Pro Leu Pro Ser 
    50                  55                  60                  


Glu Ile Leu Gly Pro Val Glu Gln Tyr Leu Gly Val Pro Tyr Ala Ser 
65                  70                  75                  80  


Pro Pro Thr Gly Glu Arg Arg Phe Gln Pro Pro Glu Ser Pro Ser Ser 
                85                  90                  95      


Trp Thr Gly Ile Arg Asn Ala Thr Gln Phe Ser Ala Val Cys Pro Gln 
            100                 105                 110         


His Leu Asp Glu Arg Phe Leu Leu His Asp Met Leu Pro Ile Trp Phe 
        115                 120                 125             


Thr Thr Ser Leu Asp Thr Leu Met Thr Tyr Val Gln Asp Gln Asn Glu 
    130                 135                 140                 


Asp Cys Leu Tyr Leu Asn Ile Tyr Val Pro Met Glu Asp Gly Thr Asn 
145                 150                 155                 160 


Ile Lys Arg Asn Ala Asp Asp Ile Thr Ser Asn Asp His Gly Glu Asp 
                165                 170                 175     


Lys Asp Ile His Glu Gln Asn Ser Lys Lys Pro Val Met Val Tyr Ile 
            180                 185                 190         


His Gly Gly Ser Tyr Met Glu Gly Thr Gly Asn Met Ile Asp Gly Ser 
        195                 200                 205             


Ile Leu Ala Ser Tyr Gly Asn Val Ile Val Ile Thr Ile Asn Tyr Arg 
    210                 215                 220                 


Leu Gly Ile Leu Gly Phe Leu Ser Thr Gly Asp Gln Ala Ala Lys Gly 
225                 230                 235                 240 


Asn Tyr Gly Leu Leu Asp Gln Ile Gln Ala Leu Arg Trp Ile Glu Glu 
                245                 250                 255     


Asn Val Gly Ala Phe Gly Gly Asp Pro Lys Arg Val Thr Ile Phe Gly 
            260                 265                 270         


Ser Gly Ala Gly Ala Ser Cys Val Ser Leu Leu Thr Leu Ser His Tyr 
        275                 280                 285             


Ser Glu Gly Leu Phe Gln Lys Ala Ile Ile Gln Ser Gly Thr Ala Leu 
    290                 295                 300                 


Ser Ser Trp Ala Val Asn Tyr Gln Pro Ala Lys Tyr Thr Arg Ile Leu 
305                 310                 315                 320 


Ala Asp Lys Val Gly Cys Asn Met Leu Asp Thr Thr Asp Met Val Glu 
                325                 330                 335     


Cys Leu Lys Asn Lys Asn Tyr Lys Glu Leu Ile Gln Gln Thr Ile Thr 
            340                 345                 350         


Pro Ala Thr Tyr His Ile Ala Phe Gly Pro Val Ile Asp Gly Asp Val 
        355                 360                 365             


Ile Pro Asp Asp Pro Gln Ile Leu Met Glu Gln Gly Glu Phe Leu Asn 
    370                 375                 380                 


Tyr Asp Ile Met Leu Gly Val Asn Gln Gly Glu Gly Leu Lys Phe Val 
385                 390                 395                 400 


Asp Gly Ile Val Asp Asn Glu Asp Gly Val Thr Pro Asn Asp Phe Asp 
                405                 410                 415     


Phe Ser Val Ser Asn Phe Val Asp Asn Leu Tyr Gly Tyr Pro Glu Gly 
            420                 425                 430         


Lys Asp Thr Leu Arg Glu Thr Ile Lys Phe Met Tyr Thr Asp Trp Ala 
        435                 440                 445             


Asp Lys Glu Asn Pro Glu Thr Arg Arg Lys Thr Leu Val Ala Leu Phe 
    450                 455                 460                 


Thr Asp His Gln Trp Val Ala Pro Ala Val Ala Thr Ala Asp Leu His 
465                 470                 475                 480 


Ala Gln Tyr Gly Ser Pro Thr Tyr Phe Tyr Ala Phe Tyr His His Cys 
                485                 490                 495     


Gln Ser Glu Met Lys Pro Ser Trp Ala Asp Ser Ala His Gly Asp Glu 
            500                 505                 510         


Val Pro Tyr Val Phe Gly Ile Pro Met Ile Gly Pro Thr Glu Leu Phe 
        515                 520                 525             


Ser Cys Asn Phe Ser Lys Asn Asp Val Met Leu Ser Ala Val Val Met 
    530                 535                 540                 


Thr Tyr Trp Thr Asn Phe Ala Lys Thr Gly Asp Pro Asn Gln Pro Val 
545                 550                 555                 560 


Pro Gln Asp Thr Lys Phe Ile His Thr Lys Pro Asn Arg Phe Glu Glu 
                565                 570                 575     


Val Ala Trp Ser Lys Tyr Asn Pro Lys Asp Gln Leu Tyr Leu His Ile 
            580                 585                 590         


Gly Leu Lys Pro Arg Val Arg Asp His Tyr Arg Ala Thr Lys Val Ala 
        595                 600                 605             


Phe Trp Leu Glu Leu Val Pro His Leu His Asn Leu Asn Glu Ile Phe 
    610                 615                 620                 


Gln Tyr Val Ser Thr Thr Thr Lys Val Pro Pro Pro Asp Met Thr Ser 
625                 630                 635                 640 


Phe Pro Tyr Gly Thr Arg Arg Ser Pro Ala Lys Ile Trp Pro Thr Thr 
                645                 650                 655     


Lys Arg Pro Ala Ile Thr Pro Ala Asn Asn Pro Lys His Ser Lys Asp 
            660                 665                 670         


Pro His Lys Thr Gly Pro Glu Asp Thr Thr Val Leu Ile Glu Thr Lys 
        675                 680                 685             


Arg Asp Tyr Ser Thr Glu Leu Ser Val Thr Ile Ala Val Gly Ala Ser 
    690                 695                 700                 


Leu Leu Phe Leu Asn Ile Leu Ala Phe Ala Ala Leu Tyr Tyr Lys Lys 
705                 710                 715                 720 


Asp Lys Arg Arg His Glu Thr His Arg His Pro Ser Pro Gln Arg Asn 
                725                 730                 735     


Thr Thr Asn Asp Ile Thr His Ile Gln Asn Glu Glu Ile Met Ser Leu 
            740                 745                 750         


Gln Met Lys Gln Leu Glu His Asp His Glu Cys Glu Ser Leu Gln Ala 
        755                 760                 765             


His Asp Thr Leu Arg Leu Thr Cys Pro Pro Asp Tyr Thr Leu Thr Leu 
    770                 775                 780                 


Arg Arg Ser Pro Asp Asp Ile Pro Phe Met Thr Pro Asn Thr Ile Thr 
785                 790                 795                 800 


Met Ile Pro Asn Thr Leu Met Gly Met Gln Pro Leu His Thr Phe Lys 
                805                 810                 815     


Thr Phe Ser Gly Gly Gln Asn Ser Thr Asn Leu Pro His Gly His Ser 
            820                 825                 830         


Thr Thr Arg Val 
        835     


<210>  9388
<211>  648
<212>  PRT
<213>  Homo Sapiens

<400>  9388

Met Val Tyr Ile His Gly Gly Ser Tyr Met Glu Gly Thr Gly Asn Met 
1               5                   10                  15      


Ile Asp Gly Ser Ile Leu Ala Ser Tyr Gly Asn Val Ile Val Ile Thr 
            20                  25                  30          


Ile Asn Tyr Arg Leu Gly Ile Leu Gly Phe Leu Ser Thr Gly Asp Gln 
        35                  40                  45              


Ala Ala Lys Gly Asn Tyr Gly Leu Leu Asp Gln Ile Gln Ala Leu Arg 
    50                  55                  60                  


Trp Ile Glu Glu Asn Val Gly Ala Phe Gly Gly Asp Pro Lys Arg Val 
65                  70                  75                  80  


Thr Ile Phe Gly Ser Gly Ala Gly Ala Ser Cys Val Ser Leu Leu Thr 
                85                  90                  95      


Leu Ser His Tyr Ser Glu Gly Leu Phe Gln Lys Ala Ile Ile Gln Ser 
            100                 105                 110         


Gly Thr Ala Leu Ser Ser Trp Ala Val Asn Tyr Gln Pro Ala Lys Tyr 
        115                 120                 125             


Thr Arg Ile Leu Ala Asp Lys Val Gly Cys Asn Met Leu Asp Thr Thr 
    130                 135                 140                 


Asp Met Val Glu Cys Leu Lys Asn Lys Asn Tyr Lys Glu Leu Ile Gln 
145                 150                 155                 160 


Gln Thr Ile Thr Pro Ala Thr Tyr His Ile Ala Phe Gly Pro Val Ile 
                165                 170                 175     


Asp Gly Asp Val Ile Pro Asp Asp Pro Gln Ile Leu Met Glu Gln Gly 
            180                 185                 190         


Glu Phe Leu Asn Tyr Asp Ile Met Leu Gly Val Asn Gln Gly Glu Gly 
        195                 200                 205             


Leu Lys Phe Val Asp Gly Ile Val Asp Asn Glu Asp Gly Val Thr Pro 
    210                 215                 220                 


Asn Asp Phe Asp Phe Ser Val Ser Asn Phe Val Asp Asn Leu Tyr Gly 
225                 230                 235                 240 


Tyr Pro Glu Gly Lys Asp Thr Leu Arg Glu Thr Ile Lys Phe Met Tyr 
                245                 250                 255     


Thr Asp Trp Ala Asp Lys Glu Asn Pro Glu Thr Arg Arg Lys Thr Leu 
            260                 265                 270         


Val Ala Leu Phe Thr Asp His Gln Trp Val Ala Pro Ala Val Ala Thr 
        275                 280                 285             


Ala Asp Leu His Ala Gln Tyr Gly Ser Pro Thr Tyr Phe Tyr Ala Phe 
    290                 295                 300                 


Tyr His His Cys Gln Ser Glu Met Lys Pro Ser Trp Ala Asp Ser Ala 
305                 310                 315                 320 


His Gly Asp Glu Val Pro Tyr Val Phe Gly Ile Pro Met Ile Gly Pro 
                325                 330                 335     


Thr Glu Leu Phe Ser Cys Asn Phe Ser Lys Asn Asp Val Met Leu Ser 
            340                 345                 350         


Ala Val Val Met Thr Tyr Trp Thr Asn Phe Ala Lys Thr Gly Asp Pro 
        355                 360                 365             


Asn Gln Pro Val Pro Gln Asp Thr Lys Phe Ile His Thr Lys Pro Asn 
    370                 375                 380                 


Arg Phe Glu Glu Val Ala Trp Ser Lys Tyr Asn Pro Lys Asp Gln Leu 
385                 390                 395                 400 


Tyr Leu His Ile Gly Leu Lys Pro Arg Val Arg Asp His Tyr Arg Ala 
                405                 410                 415     


Thr Lys Val Ala Phe Trp Leu Glu Leu Val Pro His Leu His Asn Leu 
            420                 425                 430         


Asn Glu Ile Phe Gln Tyr Val Ser Thr Thr Thr Lys Val Pro Pro Pro 
        435                 440                 445             


Asp Met Thr Ser Phe Pro Tyr Gly Thr Arg Arg Ser Pro Ala Lys Ile 
    450                 455                 460                 


Trp Pro Thr Thr Lys Arg Pro Ala Ile Thr Pro Ala Asn Asn Pro Lys 
465                 470                 475                 480 


His Ser Lys Asp Pro His Lys Thr Gly Pro Glu Asp Thr Thr Val Leu 
                485                 490                 495     


Ile Glu Thr Lys Arg Asp Tyr Ser Thr Glu Leu Ser Val Thr Ile Ala 
            500                 505                 510         


Val Gly Ala Ser Leu Leu Phe Leu Asn Ile Leu Ala Phe Ala Ala Leu 
        515                 520                 525             


Tyr Tyr Lys Lys Asp Lys Arg Arg His Glu Thr His Arg His Pro Ser 
    530                 535                 540                 


Pro Gln Arg Asn Thr Thr Asn Asp Ile Thr His Ile Gln Asn Glu Glu 
545                 550                 555                 560 


Ile Met Ser Leu Gln Met Lys Gln Leu Glu His Asp His Glu Cys Glu 
                565                 570                 575     


Ser Leu Gln Ala His Asp Thr Leu Arg Leu Thr Cys Pro Pro Asp Tyr 
            580                 585                 590         


Thr Leu Thr Leu Arg Arg Ser Pro Asp Asp Ile Pro Phe Met Thr Pro 
        595                 600                 605             


Asn Thr Ile Thr Met Ile Pro Asn Thr Leu Met Gly Met Gln Pro Leu 
    610                 615                 620                 


His Thr Phe Lys Thr Phe Ser Gly Gly Gln Asn Ser Thr Asn Leu Pro 
625                 630                 635                 640 


His Gly His Ser Thr Thr Arg Val 
                645             


<210>  9389
<211>  236
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9389

Xaa Asn Ser Asn Val Leu Leu Trp Ile Thr Ala Leu Ala Ile Lys Phe 
1               5                   10                  15      


Thr Leu Ile Asp Ser Gln Ala Gln Tyr Pro Val Val Asn Thr Asn Tyr 
            20                  25                  30          


Gly Lys Ile Gln Gly Leu Arg Thr Pro Leu Pro Ser Glu Ile Leu Gly 
        35                  40                  45              


Pro Val Glu Gln Tyr Leu Gly Val Pro Tyr Ala Ser Pro Pro Thr Gly 
    50                  55                  60                  


Glu Arg Arg Phe Gln Pro Pro Glu Ser Pro Ser Ser Trp Thr Gly Ile 
65                  70                  75                  80  


Arg Asn Ala Thr Gln Phe Ser Ala Val Cys Pro Gln His Leu Asp Glu 
                85                  90                  95      


Arg Phe Leu Leu His Asp Met Leu Pro Ile Trp Phe Thr Thr Ser Leu 
            100                 105                 110         


Asp Thr Leu Met Thr Tyr Val Gln Asp Gln Asn Glu Asp Cys Leu Tyr 
        115                 120                 125             


Leu Asn Ile Tyr Val Pro Met Glu Asp Gly Thr Asn Ile Lys Arg Asn 
    130                 135                 140                 


Ala Asp Asp Ile Thr Ser Asn Asp His Gly Glu Asp Lys Asp Ile His 
145                 150                 155                 160 


Glu Gln Asn Ser Lys Lys Pro Val Met Val Tyr Ile His Gly Gly Ser 
                165                 170                 175     


Tyr Met Glu Gly Thr Gly Asn Met Ile Asp Gly Ser Ile Leu Ala Ser 
            180                 185                 190         


Tyr Gly Asn Val Ile Val Ile Thr Ile Asn Tyr Arg Leu Gly Ile Leu 
        195                 200                 205             


Gly Met Gln Glu Ala Arg Leu Cys Gly Ser Ser Lys Met Phe Asn Tyr 
    210                 215                 220                 


Phe Lys Ser Pro Phe Thr Asn Leu Ile Asn Phe Phe 
225                 230                 235     


<210>  9390
<211>  178
<212>  PRT
<213>  Homo Sapiens

<400>  9390

Gly Pro Thr Cys Ser Ile Leu Pro Lys Asn Pro Leu Phe Pro Gln Asn 
1               5                   10                  15      


Leu Ser Ser Gln Pro Cys Ile Lys Met Glu Gly Asp Lys Ser Leu Thr 
            20                  25                  30          


Phe Ser Ser Tyr Gly Leu Gln Trp Cys Leu Tyr Glu Leu Asp Lys Glu 
        35                  40                  45              


Glu Phe Gln Thr Phe Lys Glu Leu Leu Lys Lys Lys Ser Ser Glu Ser 
    50                  55                  60                  


Thr Thr Cys Ser Ile Pro Gln Phe Glu Ile Glu Asn Ala Asn Val Glu 
65                  70                  75                  80  


Cys Leu Ala Leu Leu Leu His Glu Tyr Tyr Gly Ala Ser Leu Ala Trp 
                85                  90                  95      


Ala Thr Ser Ile Ser Ile Phe Glu Asn Met Asn Leu Arg Thr Leu Ser 
            100                 105                 110         


Glu Lys Ala Arg Asp Asp Met Lys Arg His Ser Pro Glu Asp Pro Glu 
        115                 120                 125             


Ala Thr Met Thr Asp Gln Gly Pro Ser Lys Glu Lys Val Pro Gly Ile 
    130                 135                 140                 


Ser Gln Ala Val Gln Gln Asp Ser Ala Thr Ala Ala Glu Thr Lys Glu 
145                 150                 155                 160 


Gln Glu Ser Phe Ala Val Leu Leu Arg Leu Gln Cys Ser Gly Tyr Pro 
                165                 170                 175     


Gln Ala 
        


<210>  9391
<211>  1200
<212>  PRT
<213>  Homo Sapiens

<400>  9391

Met Lys Val Ala Gly Gly Leu Glu Leu Gly Ala Ala Ala Leu Leu Ser 
1               5                   10                  15      


Ala Ser Pro Arg Ala Leu Val Thr Leu Ser Thr Gly Pro Thr Cys Ser 
            20                  25                  30          


Ile Leu Pro Lys Asn Pro Leu Phe Pro Gln Asn Leu Ser Ser Gln Pro 
        35                  40                  45              


Cys Ile Lys Met Glu Gly Asp Lys Ser Leu Thr Phe Ser Ser Tyr Gly 
    50                  55                  60                  


Leu Gln Trp Cys Leu Tyr Glu Leu Asp Lys Glu Glu Phe Gln Thr Phe 
65                  70                  75                  80  


Lys Glu Leu Leu Lys Lys Lys Ser Ser Glu Ser Thr Thr Cys Ser Ile 
                85                  90                  95      


Pro Gln Phe Glu Ile Glu Asn Ala Asn Val Glu Cys Leu Ala Leu Leu 
            100                 105                 110         


Leu His Glu Tyr Tyr Gly Ala Ser Leu Ala Trp Ala Thr Ser Ile Ser 
        115                 120                 125             


Ile Phe Glu Asn Met Asn Leu Arg Thr Leu Ser Glu Lys Ala Arg Asp 
    130                 135                 140                 


Asp Met Lys Arg His Ser Pro Glu Asp Pro Glu Ala Thr Met Thr Asp 
145                 150                 155                 160 


Gln Gly Pro Ser Lys Glu Lys Val Pro Asp Ile Ser Asp Ser Asn Asn 
                165                 170                 175     


Lys His Lys Tyr Val Gly Ile His Ser Ser Phe Ala Glu Ile Ser Gln 
            180                 185                 190         


Ala Met Glu Gln Glu Gly Ala Thr Ala Ala Glu Thr Glu Glu Gln Glu 
        195                 200                 205             


Ile Ser Gln Ala Met Glu Gln Glu Gly Ala Thr Ala Ala Glu Thr Glu 
    210                 215                 220                 


Glu Gln Gly His Gly Gly Asp Thr Trp Asp Tyr Lys Ser His Val Met 
225                 230                 235                 240 


Thr Lys Phe Ala Glu Glu Glu Asp Val Arg Arg Ser Phe Glu Asn Thr 
                245                 250                 255     


Ala Ala Asp Trp Pro Glu Met Gln Thr Leu Ala Gly Ala Phe Asp Ser 
            260                 265                 270         


Asp Arg Trp Gly Phe Arg Pro Arg Thr Val Val Leu His Gly Lys Ser 
        275                 280                 285             


Gly Ile Gly Lys Ser Ala Leu Ala Arg Arg Ile Val Leu Cys Trp Ala 
    290                 295                 300                 


Gln Gly Gly Leu Tyr Gln Gly Met Phe Ser Tyr Val Phe Phe Leu Pro 
305                 310                 315                 320 


Val Arg Glu Met Gln Arg Lys Lys Glu Ser Ser Val Thr Glu Phe Ile 
                325                 330                 335     


Ser Arg Glu Trp Pro Asp Ser Gln Ala Pro Val Thr Glu Ile Met Ser 
            340                 345                 350         


Arg Pro Glu Arg Leu Leu Phe Ile Ile Asp Gly Phe Asp Asp Leu Gly 
        355                 360                 365             


Ser Val Leu Asn Asn Asp Thr Lys Leu Cys Lys Asp Trp Ala Glu Lys 
    370                 375                 380                 


Gln Pro Pro Phe Thr Leu Ile Arg Ser Leu Leu Arg Lys Val Leu Leu 
385                 390                 395                 400 


Pro Glu Ser Phe Leu Ile Val Thr Val Arg Asp Val Gly Thr Glu Lys 
                405                 410                 415     


Leu Lys Ser Glu Val Val Ser Pro Arg Tyr Leu Leu Val Arg Gly Ile 
            420                 425                 430         


Ser Gly Glu Gln Arg Ile His Leu Leu Leu Glu Arg Gly Ile Gly Glu 
        435                 440                 445             


His Gln Lys Thr Gln Gly Leu Arg Ala Ile Met Asn Asn Arg Glu Leu 
    450                 455                 460                 


Leu Asp Gln Cys Gln Val Pro Ala Val Gly Ser Leu Ile Cys Val Ala 
465                 470                 475                 480 


Leu Gln Leu Gln Asp Val Val Gly Glu Ser Val Ala Pro Phe Asn Gln 
                485                 490                 495     


Thr Leu Thr Gly Leu His Ala Ala Phe Val Phe His Gln Leu Thr Pro 
            500                 505                 510         


Arg Gly Val Val Arg Arg Cys Leu Asn Leu Glu Glu Arg Val Val Leu 
        515                 520                 525             


Lys Arg Phe Cys Arg Met Ala Val Glu Gly Val Trp Asn Arg Lys Ser 
    530                 535                 540                 


Val Phe Asp Gly Asp Asp Leu Met Val Gln Gly Leu Gly Glu Ser Glu 
545                 550                 555                 560 


Leu Arg Ala Leu Phe His Met Asn Ile Leu Leu Pro Asp Ser His Cys 
                565                 570                 575     


Glu Glu Tyr Tyr Thr Phe Phe His Leu Ser Leu Gln Asp Phe Cys Ala 
            580                 585                 590         


Ala Leu Tyr Tyr Val Leu Glu Gly Leu Glu Ile Glu Pro Ala Leu Cys 
        595                 600                 605             


Pro Leu Tyr Val Glu Lys Thr Lys Arg Ser Met Glu Leu Lys Gln Ala 
    610                 615                 620                 


Gly Phe His Ile His Ser Leu Trp Met Lys Arg Phe Leu Phe Gly Leu 
625                 630                 635                 640 


Val Ser Glu Asp Val Arg Arg Pro Leu Glu Val Leu Leu Gly Cys Pro 
                645                 650                 655     


Val Pro Leu Gly Val Lys Gln Lys Leu Leu His Trp Val Ser Leu Leu 
            660                 665                 670         


Gly Gln Gln Pro Asn Ala Thr Thr Pro Gly Asp Thr Leu Asp Ala Phe 
        675                 680                 685             


His Cys Leu Phe Glu Thr Gln Asp Lys Glu Phe Val Arg Leu Ala Leu 
    690                 695                 700                 


Asn Ser Phe Gln Glu Val Trp Leu Pro Ile Asn Gln Asn Leu Asp Leu 
705                 710                 715                 720 


Ile Ala Ser Ser Phe Cys Leu Gln His Cys Pro Tyr Leu Arg Lys Ile 
                725                 730                 735     


Arg Val Asp Val Lys Gly Ile Phe Pro Arg Asp Glu Ser Ala Glu Ala 
            740                 745                 750         


Cys Pro Val Val Pro Leu Trp Met Arg Asp Lys Thr Leu Ile Glu Glu 
        755                 760                 765             


Gln Trp Glu Asp Phe Cys Ser Met Leu Gly Thr His Pro His Leu Arg 
    770                 775                 780                 


Gln Leu Asp Leu Gly Ser Ser Ile Leu Thr Glu Arg Ala Met Lys Thr 
785                 790                 795                 800 


Leu Cys Ala Lys Leu Arg His Pro Thr Cys Lys Ile Gln Thr Leu Met 
                805                 810                 815     


Phe Arg Asn Ala Gln Ile Thr Pro Gly Val Gln His Leu Trp Arg Ile 
            820                 825                 830         


Val Met Ala Asn Arg Asn Leu Arg Ser Leu Asn Leu Gly Gly Thr His 
        835                 840                 845             


Leu Lys Glu Glu Asp Val Arg Met Ala Cys Glu Ala Leu Lys His Pro 
    850                 855                 860                 


Lys Cys Leu Leu Glu Ser Leu Arg Leu Asp Cys Cys Gly Leu Thr His 
865                 870                 875                 880 


Ala Cys Tyr Leu Lys Ile Ser Gln Ile Leu Thr Thr Ser Pro Ser Leu 
                885                 890                 895     


Lys Ser Leu Ser Leu Ala Gly Asn Lys Val Thr Asp Gln Gly Val Met 
            900                 905                 910         


Pro Leu Ser Asp Ala Leu Arg Val Ser Gln Cys Ala Leu Gln Lys Leu 
        915                 920                 925             


Ile Leu Glu Asp Cys Gly Ile Thr Ala Thr Gly Cys Gln Ser Leu Ala 
    930                 935                 940                 


Ser Ala Leu Val Ser Asn Arg Ser Leu Thr His Leu Cys Leu Ser Asn 
945                 950                 955                 960 


Asn Ser Leu Gly Asn Glu Gly Val Asn Leu Leu Cys Arg Ser Met Arg 
                965                 970                 975     


Leu Pro His Cys Ser Leu Gln Arg Leu Met Leu Asn Gln Cys His Leu 
            980                 985                 990         


Asp Thr Ala Gly Cys Gly Phe Leu  Ala Leu Ala Leu Met  Gly Asn Ser 
        995                 1000                 1005             


Trp Leu  Thr His Leu Ser Leu  Ser Met Asn Pro Val  Glu Asp Asn 
    1010                 1015                 1020             


Gly Val  Lys Leu Leu Cys Glu  Val Met Arg Glu Pro  Ser Cys His 
    1025                 1030                 1035             


Leu Gln  Asp Leu Glu Leu Val  Lys Cys His Leu Thr  Ala Ala Cys 
    1040                 1045                 1050             


Cys Glu  Ser Leu Ser Cys Val  Ile Ser Arg Ser Arg  His Leu Lys 
    1055                 1060                 1065             


Ser Leu  Asp Leu Thr Asp Asn  Ala Leu Gly Asp Gly  Gly Val Ala 
    1070                 1075                 1080             


Ala Leu  Cys Glu Gly Leu Lys  Gln Lys Asn Ser Val  Leu Ala Arg 
    1085                 1090                 1095             


Leu Gly  Leu Lys Ala Cys Gly  Leu Thr Ser Asp Cys  Cys Glu Ala 
    1100                 1105                 1110             


Leu Ser  Leu Ala Leu Ser Cys  Asn Arg His Leu Thr  Ser Leu Asn 
    1115                 1120                 1125             


Leu Val  Gln Asn Asn Phe Ser  Pro Lys Gly Met Met  Lys Leu Cys 
    1130                 1135                 1140             


Ser Ala  Phe Ala Cys Pro Thr  Ser Asn Leu Gln Ile  Ile Gly Leu 
    1145                 1150                 1155             


Trp Lys  Trp Gln Tyr Pro Val  Gln Ile Arg Lys Leu  Leu Glu Glu 
    1160                 1165                 1170             


Val Gln  Leu Leu Lys Pro Arg  Val Val Ile Asp Gly  Ser Trp His 
    1175                 1180                 1185             


Ser Phe  Asp Glu Asp Asp Arg  Tyr Trp Trp Lys Asn  
    1190                 1195                 1200 


<210>  9392
<211>  1200
<212>  PRT
<213>  Homo Sapiens

<400>  9392

Met Lys Val Ala Gly Gly Leu Glu Leu Gly Ala Ala Ala Leu Leu Ser 
1               5                   10                  15      


Ala Ser Pro Arg Ala Leu Val Thr Leu Ser Thr Gly Pro Thr Cys Ser 
            20                  25                  30          


Ile Leu Pro Lys Asn Pro Leu Phe Pro Gln Asn Leu Ser Ser Gln Pro 
        35                  40                  45              


Cys Ile Lys Met Glu Gly Asp Lys Ser Leu Thr Phe Ser Ser Tyr Gly 
    50                  55                  60                  


Leu Gln Trp Cys Leu Tyr Glu Leu Asp Lys Glu Glu Phe Gln Thr Phe 
65                  70                  75                  80  


Lys Glu Leu Leu Lys Lys Lys Ser Ser Glu Ser Thr Thr Cys Ser Ile 
                85                  90                  95      


Pro Gln Phe Glu Ile Glu Asn Ala Asn Val Glu Cys Leu Ala Leu Leu 
            100                 105                 110         


Leu His Glu Tyr Tyr Gly Ala Ser Leu Ala Trp Ala Thr Ser Ile Ser 
        115                 120                 125             


Ile Phe Glu Asn Met Asn Leu Arg Thr Leu Ser Glu Lys Ala Arg Asp 
    130                 135                 140                 


Asp Met Lys Arg His Ser Pro Glu Asp Pro Glu Ala Thr Met Thr Asp 
145                 150                 155                 160 


Gln Gly Pro Ser Lys Glu Lys Val Pro Gly Ile Ser Gln Ala Val Gln 
                165                 170                 175     


Gln Asp Ser Ala Thr Ala Ala Glu Thr Lys Glu Gln Glu Ile Ser Gln 
            180                 185                 190         


Ala Met Glu Gln Glu Gly Ala Thr Ala Ala Glu Thr Glu Glu Gln Glu 
        195                 200                 205             


Ile Ser Gln Ala Met Glu Gln Glu Gly Ala Thr Ala Ala Glu Thr Glu 
    210                 215                 220                 


Glu Gln Gly His Gly Gly Asp Thr Trp Asp Tyr Lys Ser His Val Met 
225                 230                 235                 240 


Thr Lys Phe Ala Glu Glu Glu Asp Val Arg Arg Ser Phe Glu Asn Thr 
                245                 250                 255     


Ala Ala Asp Trp Pro Glu Met Gln Thr Leu Ala Gly Ala Phe Asp Ser 
            260                 265                 270         


Asp Arg Trp Gly Phe Arg Pro Arg Thr Val Val Leu His Gly Lys Ser 
        275                 280                 285             


Gly Ile Gly Lys Ser Ala Leu Ala Arg Arg Ile Val Leu Cys Trp Ala 
    290                 295                 300                 


Gln Gly Gly Leu Tyr Gln Gly Met Phe Ser Tyr Val Phe Phe Leu Pro 
305                 310                 315                 320 


Val Arg Glu Met Gln Arg Lys Lys Glu Ser Ser Val Thr Glu Phe Ile 
                325                 330                 335     


Ser Arg Glu Trp Pro Asp Ser Gln Ala Pro Val Thr Glu Ile Met Ser 
            340                 345                 350         


Arg Pro Glu Arg Leu Leu Phe Ile Ile Asp Gly Phe Asp Asp Leu Gly 
        355                 360                 365             


Ser Val Leu Asn Asn Asp Thr Lys Leu Cys Lys Asp Trp Ala Glu Lys 
    370                 375                 380                 


Gln Pro Pro Phe Thr Leu Ile Arg Ser Leu Leu Arg Lys Val Leu Leu 
385                 390                 395                 400 


Pro Glu Ser Phe Leu Ile Val Thr Val Arg Asp Val Gly Thr Glu Lys 
                405                 410                 415     


Leu Lys Ser Glu Val Val Ser Pro Arg Tyr Leu Leu Val Arg Gly Ile 
            420                 425                 430         


Ser Gly Glu Gln Arg Ile His Leu Leu Leu Glu Arg Gly Ile Gly Glu 
        435                 440                 445             


His Gln Lys Thr Gln Gly Leu Arg Ala Ile Met Asn Asn Arg Glu Leu 
    450                 455                 460                 


Leu Asp Gln Cys Gln Val Pro Ala Val Gly Ser Leu Ile Cys Val Ala 
465                 470                 475                 480 


Leu Gln Leu Gln Asp Val Val Gly Glu Ser Val Ala Pro Phe Asn Gln 
                485                 490                 495     


Thr Leu Thr Gly Leu His Ala Ala Phe Val Phe His Gln Leu Thr Pro 
            500                 505                 510         


Arg Gly Val Val Arg Arg Cys Leu Asn Leu Glu Glu Arg Val Val Leu 
        515                 520                 525             


Lys Arg Phe Cys Arg Met Ala Val Glu Gly Val Trp Asn Arg Lys Ser 
    530                 535                 540                 


Val Phe Asp Gly Asp Asp Leu Met Val Gln Gly Leu Gly Glu Ser Glu 
545                 550                 555                 560 


Leu Arg Ala Leu Phe His Met Asn Ile Leu Leu Pro Asp Ser His Cys 
                565                 570                 575     


Glu Glu Tyr Tyr Thr Phe Phe His Leu Ser Leu Gln Asp Phe Cys Ala 
            580                 585                 590         


Ala Leu Tyr Tyr Val Leu Glu Gly Leu Glu Ile Glu Pro Ala Leu Cys 
        595                 600                 605             


Pro Leu Tyr Val Glu Lys Thr Lys Arg Ser Met Glu Leu Lys Gln Ala 
    610                 615                 620                 


Gly Phe His Ile His Ser Leu Trp Met Lys Arg Phe Leu Phe Gly Leu 
625                 630                 635                 640 


Val Ser Glu Asp Val Arg Arg Pro Leu Glu Val Leu Leu Gly Cys Pro 
                645                 650                 655     


Val Pro Leu Gly Val Lys Gln Lys Leu Leu His Trp Val Ser Leu Leu 
            660                 665                 670         


Gly Gln Gln Pro Asn Ala Thr Thr Pro Gly Asp Thr Leu Asp Ala Phe 
        675                 680                 685             


His Cys Leu Phe Glu Thr Gln Asp Lys Glu Phe Val Arg Leu Ala Leu 
    690                 695                 700                 


Asn Ser Phe Gln Glu Val Trp Leu Pro Ile Asn Gln Asn Leu Asp Leu 
705                 710                 715                 720 


Ile Ala Ser Ser Phe Cys Leu Gln His Cys Pro Tyr Leu Arg Lys Ile 
                725                 730                 735     


Arg Val Asp Val Lys Gly Ile Phe Pro Arg Asp Glu Ser Ala Glu Ala 
            740                 745                 750         


Cys Pro Val Val Pro Leu Trp Met Arg Asp Lys Thr Leu Ile Glu Glu 
        755                 760                 765             


Gln Trp Glu Asp Phe Cys Ser Met Leu Gly Thr His Pro His Leu Arg 
    770                 775                 780                 


Gln Leu Asp Leu Gly Ser Ser Ile Leu Thr Glu Arg Ala Met Lys Thr 
785                 790                 795                 800 


Leu Cys Ala Lys Leu Arg His Pro Thr Cys Lys Ile Gln Thr Leu Met 
                805                 810                 815     


Phe Arg Asn Ala Gln Ile Thr Pro Gly Val Gln His Leu Trp Arg Ile 
            820                 825                 830         


Val Met Ala Asn Arg Asn Leu Arg Ser Leu Asn Leu Gly Gly Thr His 
        835                 840                 845             


Leu Lys Glu Glu Asp Val Arg Met Ala Cys Glu Ala Leu Lys His Pro 
    850                 855                 860                 


Lys Cys Leu Leu Glu Ser Leu Arg Leu Asp Cys Cys Gly Leu Thr His 
865                 870                 875                 880 


Ala Cys Tyr Leu Lys Ile Ser Gln Ile Leu Thr Thr Ser Pro Ser Leu 
                885                 890                 895     


Lys Ser Leu Ser Leu Ala Gly Asn Lys Val Thr Asp Gln Gly Val Met 
            900                 905                 910         


Pro Leu Ser Asp Ala Leu Arg Val Ser Gln Cys Ala Leu Gln Lys Leu 
        915                 920                 925             


Ile Leu Glu Asp Cys Gly Ile Thr Ala Thr Gly Cys Gln Ser Leu Ala 
    930                 935                 940                 


Ser Ala Leu Val Ser Asn Arg Ser Leu Thr His Leu Cys Leu Ser Asn 
945                 950                 955                 960 


Asn Ser Leu Gly Asn Glu Gly Val Asn Leu Leu Cys Arg Ser Met Arg 
                965                 970                 975     


Leu Pro His Cys Ser Leu Gln Arg Leu Met Leu Asn Gln Cys His Leu 
            980                 985                 990         


Asp Thr Ala Gly Cys Gly Phe Leu  Ala Leu Ala Leu Met  Gly Asn Ser 
        995                 1000                 1005             


Trp Leu  Thr His Leu Ser Leu  Ser Met Asn Pro Val  Glu Asp Asn 
    1010                 1015                 1020             


Gly Val  Lys Leu Leu Cys Glu  Val Met Arg Glu Pro  Ser Cys His 
    1025                 1030                 1035             


Leu Gln  Asp Leu Glu Leu Val  Lys Cys His Leu Thr  Ala Ala Cys 
    1040                 1045                 1050             


Cys Glu  Ser Leu Ser Cys Val  Ile Ser Arg Ser Arg  His Leu Lys 
    1055                 1060                 1065             


Ser Leu  Asp Leu Thr Asp Asn  Ala Leu Gly Asp Gly  Gly Val Ala 
    1070                 1075                 1080             


Ala Leu  Cys Glu Gly Leu Lys  Gln Lys Asn Ser Val  Leu Ala Arg 
    1085                 1090                 1095             


Leu Gly  Leu Lys Ala Cys Gly  Leu Thr Ser Asp Cys  Cys Glu Ala 
    1100                 1105                 1110             


Leu Ser  Leu Ala Leu Ser Cys  Asn Arg His Leu Thr  Ser Leu Asn 
    1115                 1120                 1125             


Leu Val  Gln Asn Asn Phe Ser  Pro Lys Gly Met Met  Lys Leu Cys 
    1130                 1135                 1140             


Ser Ala  Phe Ala Cys Pro Thr  Ser Asn Leu Gln Ile  Ile Gly Leu 
    1145                 1150                 1155             


Trp Lys  Trp Gln Tyr Pro Val  Gln Ile Arg Lys Leu  Leu Glu Glu 
    1160                 1165                 1170             


Val Gln  Leu Leu Lys Pro Arg  Val Val Ile Asp Gly  Ser Trp His 
    1175                 1180                 1185             


Ser Phe  Asp Glu Asp Asp Arg  Tyr Trp Trp Lys Asn  
    1190                 1195                 1200 


<210>  9393
<211>  154
<212>  PRT
<213>  Homo Sapiens

<400>  9393

Met Ala Arg Arg Ala Gly Gly Ala Arg Met Phe Gly Ser Leu Leu Leu 
1               5                   10                  15      


Phe Ala Leu Leu Ala Ala Gly Val Ala Pro Leu Ser Trp Asp Leu Pro 
            20                  25                  30          


Glu Pro Arg Ser Arg Ala Ser Lys Ile Arg Val His Ser Arg Gly Asn 
        35                  40                  45              


Leu Trp Ala Thr Gly His Phe Met Gly Lys Lys Ser Leu Glu Pro Ser 
    50                  55                  60                  


Ser Pro Ser Pro Leu Gly Thr Ala Pro His Thr Ser Leu Arg Asp Gln 
65                  70                  75                  80  


Arg Leu Gln Leu Ser His Asp Leu Leu Gly Ile Leu Leu Leu Lys Lys 
                85                  90                  95      


Ala Leu Gly Val Ser Leu Ser Arg Pro Ala Pro Gln Ile Gln Glu Ala 
            100                 105                 110         


Ala Gly Thr Asn Thr Ala Glu Met Thr Pro Ile Met Gly Gln Thr Gln 
        115                 120                 125             


Gln Arg Gly Leu Asp Cys Ala His Pro Gly Lys Val Leu Asn Gly Thr 
    130                 135                 140                 


Leu Leu Met Ala Pro Ser Gly Cys Lys Ser 
145                 150                 


<210>  9394
<211>  121
<212>  PRT
<213>  Homo Sapiens

<400>  9394

Met Ala Arg Arg Ala Gly Gly Ala Arg Met Phe Gly Ser Leu Leu Leu 
1               5                   10                  15      


Phe Ala Leu Leu Ala Ala Gly Val Ala Pro Leu Ser Trp Asp Leu Pro 
            20                  25                  30          


Glu Pro Arg Ser Arg Ala Ser Lys Ile Arg Val His Ser Arg Gly Asn 
        35                  40                  45              


Leu Trp Ala Thr Gly His Phe Met Gly Lys Lys Ser Leu Glu Pro Ser 
    50                  55                  60                  


Ser Pro Ser Pro Leu Gly Thr Ala Pro His Thr Ser Leu Arg Asp Gln 
65                  70                  75                  80  


Arg Leu Gln Leu Ser His Asp Leu Leu Gly Ile Leu Leu Leu Lys Lys 
                85                  90                  95      


Ala Leu Gly Val Ser Leu Ser Arg Pro Ala Pro Gln Ile Gln Tyr Arg 
            100                 105                 110         


Arg Leu Leu Val Gln Ile Leu Gln Lys 
        115                 120     


<210>  9395
<211>  82
<212>  PRT
<213>  Homo Sapiens

<400>  9395

Met Ala Asn Cys Glu Arg Thr Phe Ile Ala Ile Lys Pro Asp Gly Val 
1               5                   10                  15      


Gln Arg Gly Leu Val Gly Glu Ile Ile Lys Arg Phe Glu Gln Lys Gly 
            20                  25                  30          


Phe Arg Leu Val Gly Leu Lys Phe Met Gln Ala Ser Glu Asp Leu Leu 
        35                  40                  45              


Lys Glu His Tyr Val Asp Leu Lys Asp Arg Pro Phe Phe Ala Gly Leu 
    50                  55                  60                  


Val Lys Tyr Met His Ser Gly Pro Val Val Ala Met Leu Pro Asp Phe 
65                  70                  75                  80  


Leu Leu 
        


<210>  9396
<211>  82
<212>  PRT
<213>  Homo Sapiens

<400>  9396

Met Ala Asn Cys Glu Arg Thr Phe Ile Ala Ile Lys Pro Asp Gly Val 
1               5                   10                  15      


Gln Arg Gly Leu Val Gly Glu Ile Ile Lys Arg Phe Glu Gln Lys Gly 
            20                  25                  30          


Phe Arg Leu Val Gly Leu Lys Phe Met Gln Ala Ser Glu Asp Leu Leu 
        35                  40                  45              


Lys Glu His Tyr Val Asp Leu Lys Asp Arg Pro Phe Phe Ala Gly Leu 
    50                  55                  60                  


Val Lys Tyr Met His Ser Gly Pro Val Val Ala Met Leu Pro Asp Phe 
65                  70                  75                  80  


Leu Leu 
        


<210>  9397
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  9397

Met Ala Asn Cys Glu Arg Thr Phe Ile Ala Ile Lys Pro Asp Gly Val 
1               5                   10                  15      


Gln Arg Gly Leu Val Gly Glu Ile Ile Lys Arg Phe Glu Gln Lys Gly 
            20                  25                  30          


Phe Arg Leu Val Gly Leu Lys Phe Met Gln Ala Ser Glu Asp Leu Leu 
        35                  40                  45              


Lys Glu His Tyr Val Asp Leu Lys Asp Arg Pro Phe Phe Ala Gly Leu 
    50                  55                  60                  


Val Lys Tyr Met His Ser Gly Pro Val Val Ala Met Val Trp Glu Gly 
65                  70                  75                  80  


Leu Asn Val Val Lys Thr Gly Arg Val Met Leu Gly Glu Thr Asn Pro 
                85                  90                  95      


Ala Asp Ser Lys Pro Gly Thr Ile Arg Gly Asp Phe Cys Ile Gln Val 
            100                 105                 110         


Gly Arg Asn Ile Ile His Gly Ser Asp Ser Val Glu Ser Ala Glu Lys 
        115                 120                 125             


Glu Ile Gly Leu Trp Phe His Pro Glu Glu Leu Val Asp Tyr Thr Ser 
    130                 135                 140                 


Cys Ala Gln Asn Trp Ile Tyr Glu 
145                 150         


<210>  9398
<211>  60
<212>  PRT
<213>  Homo Sapiens

<400>  9398

Met Val Leu Leu Ser Thr Leu Gly Ile Val Phe Gln Gly Glu Gly Pro 
1               5                   10                  15      


Pro Ile Ser Ser Cys Asp Thr Gly Thr Met Ala Asn Cys Glu Arg Thr 
            20                  25                  30          


Phe Ile Ala Ile Lys Pro Asp Gly Val Gln Arg Gly Leu Val Gly Glu 
        35                  40                  45              


Ile Ile Lys Arg Phe Glu Gln Lys Gly Phe Arg Leu 
    50                  55                  60  


<210>  9399
<211>  139
<212>  PRT
<213>  Homo Sapiens

<400>  9399

Met Val Leu Leu Ser Thr Leu Gly Ile Val Phe Gln Gly Glu Gly Pro 
1               5                   10                  15      


Pro Ile Ser Ser Cys Asp Thr Gly Thr Met Ala Asn Cys Glu Arg Thr 
            20                  25                  30          


Phe Ile Ala Ile Lys Pro Asp Gly Val Gln Arg Gly Leu Val Gly Glu 
        35                  40                  45              


Ile Ile Lys Arg Phe Glu Gln Lys Gly Phe Arg Leu Val Gly Leu Lys 
    50                  55                  60                  


Phe Met Gln Ala Ser Glu Asp Leu Leu Lys Glu His Tyr Val Asp Leu 
65                  70                  75                  80  


Lys Asp Arg Pro Phe Phe Ala Gly Leu Val Lys Tyr Met His Ser Gly 
                85                  90                  95      


Pro Val Val Ala Met Val Trp Glu Gly Leu Asn Val Val Lys Thr Gly 
            100                 105                 110         


Arg Val Met Leu Gly Glu Thr Asn Pro Ala Asp Ser Lys Pro Gly Thr 
        115                 120                 125             


Ile Arg Gly Asp Phe Cys Ile Gln Val Gly Arg 
    130                 135                 


<210>  9400
<211>  177
<212>  PRT
<213>  Homo Sapiens

<400>  9400

Met Val Leu Leu Ser Thr Leu Gly Ile Val Phe Gln Gly Glu Gly Pro 
1               5                   10                  15      


Pro Ile Ser Ser Cys Asp Thr Gly Thr Met Ala Asn Cys Glu Arg Thr 
            20                  25                  30          


Phe Ile Ala Ile Lys Pro Asp Gly Val Gln Arg Gly Leu Val Gly Glu 
        35                  40                  45              


Ile Ile Lys Arg Phe Glu Gln Lys Gly Phe Arg Leu Val Gly Leu Lys 
    50                  55                  60                  


Phe Met Gln Ala Ser Glu Asp Leu Leu Lys Glu His Tyr Val Asp Leu 
65                  70                  75                  80  


Lys Asp Arg Pro Phe Phe Ala Gly Leu Val Lys Tyr Met His Ser Gly 
                85                  90                  95      


Pro Val Val Ala Met Val Trp Glu Gly Leu Asn Val Val Lys Thr Gly 
            100                 105                 110         


Arg Val Met Leu Gly Glu Thr Asn Pro Ala Asp Ser Lys Pro Gly Thr 
        115                 120                 125             


Ile Arg Gly Asp Phe Cys Ile Gln Val Gly Arg Asn Ile Ile His Gly 
    130                 135                 140                 


Ser Asp Ser Val Glu Ser Ala Glu Lys Glu Ile Gly Leu Trp Phe His 
145                 150                 155                 160 


Pro Glu Glu Leu Val Asp Tyr Thr Ser Cys Ala Gln Asn Trp Ile Tyr 
                165                 170                 175     


Glu 
    


<210>  9401
<211>  177
<212>  PRT
<213>  Homo Sapiens

<400>  9401

Met Val Leu Leu Ser Thr Leu Gly Ile Val Phe Gln Gly Glu Gly Pro 
1               5                   10                  15      


Pro Ile Ser Ser Cys Asp Thr Gly Thr Met Ala Asn Cys Glu Arg Thr 
            20                  25                  30          


Phe Ile Ala Ile Lys Pro Asp Gly Val Gln Arg Gly Leu Val Gly Glu 
        35                  40                  45              


Ile Ile Lys Arg Phe Glu Gln Lys Gly Phe Arg Leu Val Gly Leu Lys 
    50                  55                  60                  


Phe Met Gln Ala Ser Glu Asp Leu Leu Lys Glu His Tyr Val Asp Leu 
65                  70                  75                  80  


Lys Asp Arg Pro Phe Phe Ala Gly Leu Val Lys Tyr Met His Ser Gly 
                85                  90                  95      


Pro Val Val Ala Met Val Trp Glu Gly Leu Asn Val Val Lys Thr Gly 
            100                 105                 110         


Arg Val Met Leu Gly Glu Thr Asn Pro Ala Asp Ser Lys Pro Gly Thr 
        115                 120                 125             


Ile Arg Gly Asp Phe Cys Ile Gln Val Gly Arg Asn Ile Ile His Gly 
    130                 135                 140                 


Ser Asp Ser Val Glu Ser Ala Glu Lys Glu Ile Gly Leu Trp Phe His 
145                 150                 155                 160 


Pro Glu Glu Leu Val Asp Tyr Thr Ser Cys Ala Gln Asn Trp Ile Tyr 
                165                 170                 175     


Glu 
    


<210>  9402
<211>  197
<212>  PRT
<213>  Homo Sapiens

<400>  9402

Met Ala Asn Cys Glu Arg Thr Phe Ile Ala Ile Lys Pro Asp Gly Val 
1               5                   10                  15      


Gln Arg Gly Leu Val Gly Glu Ile Ile Lys Arg Phe Glu Gln Lys Gly 
            20                  25                  30          


Phe Arg Leu Val Gly Leu Lys Phe Met Gln Ala Ser Glu Asp Leu Leu 
        35                  40                  45              


Lys Glu His Tyr Val Asp Leu Lys Asp Arg Pro Phe Phe Ala Gly Leu 
    50                  55                  60                  


Val Lys Tyr Met His Ser Gly Pro Val Val Ala Met Val Trp Glu Gly 
65                  70                  75                  80  


Leu Asn Val Val Lys Thr Gly Arg Val Met Leu Gly Glu Thr Asn Pro 
                85                  90                  95      


Ala Asp Ser Lys Pro Gly Thr Ile Arg Gly Asp Phe Cys Ile Gln Val 
            100                 105                 110         


Gly Arg Thr Met Ala Asn Leu Glu Arg Thr Phe Ile Ala Ile Lys Pro 
        115                 120                 125             


Asp Gly Val Gln Arg Gly Leu Val Gly Glu Ile Ile Lys Arg Phe Glu 
    130                 135                 140                 


Gln Lys Gly Phe Arg Leu Val Ala Met Lys Phe Leu Arg Ala Ser Glu 
145                 150                 155                 160 


Glu His Leu Lys Gln His Tyr Ile Asp Leu Lys Asp Arg Pro Phe Phe 
                165                 170                 175     


Pro Gly Leu Val Lys Tyr Met Asn Ser Gly Pro Val Val Ala Met Glu 
            180                 185                 190         


His His Ser Trp Gln 
        195         


<210>  9403
<211>  267
<212>  PRT
<213>  Homo Sapiens

<400>  9403

Met Ala Asn Cys Glu Arg Thr Phe Ile Ala Ile Lys Pro Asp Gly Val 
1               5                   10                  15      


Gln Arg Gly Leu Val Gly Glu Ile Ile Lys Arg Phe Glu Gln Lys Gly 
            20                  25                  30          


Phe Arg Leu Val Gly Leu Lys Phe Met Gln Ala Ser Glu Asp Leu Leu 
        35                  40                  45              


Lys Glu His Tyr Val Asp Leu Lys Asp Arg Pro Phe Phe Ala Gly Leu 
    50                  55                  60                  


Val Lys Tyr Met His Ser Gly Pro Val Val Ala Met Val Trp Glu Gly 
65                  70                  75                  80  


Leu Asn Val Val Lys Thr Gly Arg Val Met Leu Gly Glu Thr Asn Pro 
                85                  90                  95      


Ala Asp Ser Lys Pro Gly Thr Ile Arg Gly Asp Phe Cys Ile Gln Val 
            100                 105                 110         


Gly Arg Thr Met Ala Asn Leu Glu Arg Thr Phe Ile Ala Ile Lys Pro 
        115                 120                 125             


Asp Gly Val Gln Arg Gly Leu Val Gly Glu Ile Ile Lys Arg Phe Glu 
    130                 135                 140                 


Gln Lys Gly Phe Arg Leu Val Ala Met Lys Phe Leu Arg Ala Ser Glu 
145                 150                 155                 160 


Glu His Leu Lys Gln His Tyr Ile Asp Leu Lys Asp Arg Pro Phe Phe 
                165                 170                 175     


Pro Gly Leu Val Lys Tyr Met Asn Ser Gly Pro Val Val Ala Met Val 
            180                 185                 190         


Trp Glu Gly Leu Asn Val Val Lys Thr Gly Arg Val Met Leu Gly Glu 
        195                 200                 205             


Thr Asn Pro Ala Asp Ser Lys Pro Gly Thr Ile Arg Gly Asp Phe Cys 
    210                 215                 220                 


Ile Gln Val Gly Arg Asn Ile Ile His Gly Ser Asp Ser Val Lys Ser 
225                 230                 235                 240 


Ala Glu Lys Glu Ile Ser Leu Trp Phe Lys Pro Glu Glu Leu Val Asp 
                245                 250                 255     


Tyr Lys Ser Cys Ala His Asp Trp Val Tyr Glu 
            260                 265         


<210>  9404
<211>  292
<212>  PRT
<213>  Homo Sapiens

<400>  9404

Met Val Leu Leu Ser Thr Leu Gly Ile Val Phe Gln Gly Glu Gly Pro 
1               5                   10                  15      


Pro Ile Ser Ser Cys Asp Thr Gly Thr Met Ala Asn Cys Glu Arg Thr 
            20                  25                  30          


Phe Ile Ala Ile Lys Pro Asp Gly Val Gln Arg Gly Leu Val Gly Glu 
        35                  40                  45              


Ile Ile Lys Arg Phe Glu Gln Lys Gly Phe Arg Leu Val Gly Leu Lys 
    50                  55                  60                  


Phe Met Gln Ala Ser Glu Asp Leu Leu Lys Glu His Tyr Val Asp Leu 
65                  70                  75                  80  


Lys Asp Arg Pro Phe Phe Ala Gly Leu Val Lys Tyr Met His Ser Gly 
                85                  90                  95      


Pro Val Val Ala Met Val Trp Glu Gly Leu Asn Val Val Lys Thr Gly 
            100                 105                 110         


Arg Val Met Leu Gly Glu Thr Asn Pro Ala Asp Ser Lys Pro Gly Thr 
        115                 120                 125             


Ile Arg Gly Asp Phe Cys Ile Gln Val Gly Arg Thr Met Ala Asn Leu 
    130                 135                 140                 


Glu Arg Thr Phe Ile Ala Ile Lys Pro Asp Gly Val Gln Arg Gly Leu 
145                 150                 155                 160 


Val Gly Glu Ile Ile Lys Arg Phe Glu Gln Lys Gly Phe Arg Leu Val 
                165                 170                 175     


Ala Met Lys Phe Leu Arg Ala Ser Glu Glu His Leu Lys Gln His Tyr 
            180                 185                 190         


Ile Asp Leu Lys Asp Arg Pro Phe Phe Pro Gly Leu Val Lys Tyr Met 
        195                 200                 205             


Asn Ser Gly Pro Val Val Ala Met Val Trp Glu Gly Leu Asn Val Val 
    210                 215                 220                 


Lys Thr Gly Arg Val Met Leu Gly Glu Thr Asn Pro Ala Asp Ser Lys 
225                 230                 235                 240 


Pro Gly Thr Ile Arg Gly Asp Phe Cys Ile Gln Val Gly Arg Asn Ile 
                245                 250                 255     


Ile His Gly Ser Asp Ser Val Lys Ser Ala Glu Lys Glu Ile Ser Leu 
            260                 265                 270         


Trp Phe Lys Pro Glu Glu Leu Val Asp Tyr Lys Ser Cys Ala His Asp 
        275                 280                 285             


Trp Val Tyr Glu 
    290         


<210>  9405
<211>  53
<212>  PRT
<213>  Homo Sapiens

<400>  9405

Phe Ala Asn Leu Phe Pro Ala Ala Cys Thr Gly Ala His Glu Arg Thr 
1               5                   10                  15      


Phe Leu Ala Val Lys Pro Asp Gly Val Gln Arg Arg Leu Val Gly Glu 
            20                  25                  30          


Ile Val Arg Arg Phe Glu Arg Lys Gly Phe Lys Leu Val Ala Leu Lys 
        35                  40                  45              


Leu Val Gln Ala Ala 
    50              


<210>  9406
<211>  57
<212>  PRT
<213>  Homo Sapiens

<400>  9406

Ile Phe Ala Asn Leu Phe Pro Ala Ala Cys Thr Gly Ala His Glu Arg 
1               5                   10                  15      


Thr Phe Leu Ala Val Lys Pro Asp Gly Val Gln Arg Arg Leu Val Gly 
            20                  25                  30          


Glu Ile Val Arg Arg Phe Glu Arg Lys Gly Phe Lys Arg Pro Asp Pro 
        35                  40                  45              


Ser Ala Gly Leu Arg Gly Ala Ala Ala 
    50                  55          


<210>  9407
<211>  85
<212>  PRT
<213>  Homo Sapiens

<400>  9407

Met Ala Ser Gly Pro Val Val Ala Met Val Trp Gln Gly Leu Asp Val 
1               5                   10                  15      


Val Arg Thr Ser Arg Ala Leu Ile Gly Ala Thr Asn Pro Ala Asp Ala 
            20                  25                  30          


Pro Pro Gly Thr Ile Arg Gly Asp Phe Cys Ile Glu Val Gly Lys Asn 
        35                  40                  45              


Leu Ile His Gly Ser Asp Ser Val Glu Ser Ala Arg Arg Glu Ile Ala 
    50                  55                  60                  


Leu Trp Phe Arg Ala Asp Glu Leu Leu Cys Trp Glu Asp Ser Ala Gly 
65                  70                  75                  80  


His Trp Leu Tyr Glu 
                85  


<210>  9408
<211>  169
<212>  PRT
<213>  Homo Sapiens

<400>  9408

Met Ile Cys Leu Val Leu Thr Ile Phe Ala Asn Leu Phe Pro Ala Ala 
1               5                   10                  15      


Cys Thr Gly Ala His Glu Arg Thr Phe Leu Ala Val Lys Pro Asp Gly 
            20                  25                  30          


Val Gln Arg Arg Leu Val Gly Glu Ile Val Arg Arg Phe Glu Arg Lys 
        35                  40                  45              


Gly Phe Lys Leu Val Ala Leu Lys Leu Val Gln Ala Ser Glu Glu Leu 
    50                  55                  60                  


Leu Arg Glu His Tyr Ala Glu Leu Arg Glu Arg Pro Phe Tyr Gly Arg 
65                  70                  75                  80  


Leu Val Lys Tyr Met Ala Ser Gly Pro Val Val Ala Met Val Trp Gln 
                85                  90                  95      


Gly Leu Asp Val Val Arg Thr Ser Arg Ala Leu Ile Gly Ala Thr Asn 
            100                 105                 110         


Pro Ala Asp Ala Pro Pro Gly Thr Ile Arg Gly Asp Phe Cys Ile Glu 
        115                 120                 125             


Val Gly Lys Asn Leu Ile His Gly Ser Asp Ser Val Glu Ser Ala Arg 
    130                 135                 140                 


Arg Glu Ile Ala Leu Trp Phe Arg Ala Asp Glu Leu Leu Cys Trp Glu 
145                 150                 155                 160 


Asp Ser Ala Gly His Trp Leu Tyr Glu 
                165                 


<210>  9409
<211>  123
<212>  PRT
<213>  Homo Sapiens

<400>  9409

Pro Ala Ala Cys Thr Gly Ala His Glu Arg Thr Phe Leu Ala Val Lys 
1               5                   10                  15      


Pro Asp Gly Val Gln Arg Arg Leu Val Gly Glu Ile Val Arg Arg Phe 
            20                  25                  30          


Glu Arg Lys Gly Phe Lys Leu Val Ala Leu Lys Leu Val Gln Val Gly 
        35                  40                  45              


Ala Arg Pro Pro Arg Ser Cys Cys Val Ser Thr Thr Pro Ser Cys Val 
    50                  55                  60                  


Asn Ala Arg Ser Thr Ala Ala Leu Ser Ser Ile Trp Pro Pro Gly Arg 
65                  70                  75                  80  


Trp Trp Pro Trp Tyr Gly Arg Gly Trp Thr Trp Cys Ala Pro Arg Gly 
                85                  90                  95      


Arg Ser Ser Glu Pro Arg Thr Arg Pro Thr Pro Arg Pro Ala Pro Ser 
            100                 105                 110         


Ala Gly Ile Ser Ala Ser Arg Leu Ala Arg Thr 
        115                 120             


<210>  9410
<211>  153
<212>  PRT
<213>  Homo Sapiens

<400>  9410

Met Lys His Leu Arg Pro Gln Phe Pro Leu Ile Leu Ala Ile Tyr Cys 
1               5                   10                  15      


Phe Cys Met Leu Gln Ile Pro Ser Ser Gly Phe Pro Gln Pro Leu Ala 
            20                  25                  30          


Asp Pro Ser Asp Gly Leu Asp Ile Val Gln Leu Glu Gln Leu Ala Tyr 
        35                  40                  45              


Cys Leu Ser Gln Trp Ala Pro Leu Ser Arg Gln Pro Lys Asp Asn Gln 
    50                  55                  60                  


Asp Ile Tyr Lys Arg Phe Leu Phe His Tyr Ser Arg Thr Gln Glu Ala 
65                  70                  75                  80  


Thr His Pro Val Lys Thr Gly Phe Pro Pro Val His Pro Leu Met His 
                85                  90                  95      


Leu Ala Ala Lys Leu Ala Asn Arg Arg Met Lys Arg Ile Leu Gln Arg 
            100                 105                 110         


Gly Ser Gly Thr Ala Ala Val Asp Phe Thr Lys Lys Asp His Thr Ala 
        115                 120                 125             


Thr Trp Gly Arg Pro Phe Phe Leu Phe Arg Pro Arg Asn Gly Arg Asn 
    130                 135                 140                 


Ile Glu Asp Glu Ala Gln Ile Gln Trp 
145                 150             


<210>  9411
<211>  158
<212>  PRT
<213>  Homo Sapiens

<400>  9411

Met Leu Arg Thr Glu Ser Cys Arg Pro Arg Ser Pro Ala Gly Gln Val 
1               5                   10                  15      


Ala Ala Ala Ser Pro Leu Leu Leu Leu Leu Leu Leu Leu Ala Trp Cys 
            20                  25                  30          


Ala Gly Ala Cys Arg Gly Ala Pro Ile Leu Pro Gln Gly Leu Gln Pro 
        35                  40                  45              


Glu Gln Gln Leu Gln Leu Trp Asn Glu Ala Ser Asn Ala Leu Glu Glu 
    50                  55                  60                  


Leu Cys Phe Met Ile Met Gly Met Leu Pro Lys Pro Gln Glu Gln Asp 
65                  70                  75                  80  


Glu Lys Asp Asn Thr Lys Arg Phe Leu Phe His Tyr Ser Lys Thr Gln 
                85                  90                  95      


Lys Leu Gly Lys Ser Asn Val Val Ser Ser Val Val His Pro Leu Leu 
            100                 105                 110         


Gln Leu Val Pro His Leu His Glu Arg Arg Met Lys Arg Phe Arg Val 
        115                 120                 125             


Asp Glu Glu Phe Gln Ser Pro Phe Ala Ser Gln Ser Arg Gly Tyr Phe 
    130                 135                 140                 


Leu Phe Arg Pro Arg Asn Gly Arg Arg Ser Ala Gly Phe Ile 
145                 150                 155             


<210>  9412
<211>  149
<212>  PRT
<213>  Homo Sapiens

<400>  9412

Met Leu Arg Thr Glu Ser Cys Arg Pro Arg Ser Pro Ala Gly Gln Val 
1               5                   10                  15      


Ala Ala Ala Ser Pro Leu Leu Leu Leu Leu Leu Leu Leu Ala Trp Cys 
            20                  25                  30          


Ala Gly Ala Cys Arg Gly Ala Pro Ile Leu Pro Gln Gly Leu Gln Pro 
        35                  40                  45              


Glu Gln Gln Leu Gln Leu Trp Asn Glu Ile Asp Asp Thr Cys Ser Ser 
    50                  55                  60                  


Phe Leu Ser Ile Asp Ser Gln Pro Gln Ala Ser Asn Ala Leu Glu Glu 
65                  70                  75                  80  


Leu Cys Phe Met Ile Met Gly Met Leu Pro Lys Pro Gln Glu Gln Asp 
                85                  90                  95      


Glu Lys Asp Asn Thr Lys Arg Phe Leu Phe His Tyr Ser Lys Thr Gln 
            100                 105                 110         


Lys Leu Gly Lys Ser Asn Val Val Glu Glu Phe Gln Ser Pro Phe Ala 
        115                 120                 125             


Ser Gln Ser Arg Gly Tyr Phe Leu Phe Arg Pro Arg Asn Gly Arg Arg 
    130                 135                 140                 


Ser Ala Gly Phe Ile 
145                 


<210>  9413
<211>  174
<212>  PRT
<213>  Homo Sapiens

<400>  9413

Met Leu Arg Thr Glu Ser Cys Arg Pro Arg Ser Pro Ala Gly Gln Val 
1               5                   10                  15      


Ala Ala Ala Ser Pro Leu Leu Leu Leu Leu Leu Leu Leu Ala Trp Cys 
            20                  25                  30          


Ala Gly Ala Cys Arg Gly Ala Pro Ile Leu Pro Gln Gly Leu Gln Pro 
        35                  40                  45              


Glu Gln Gln Leu Gln Leu Trp Asn Glu Ile Asp Asp Thr Cys Ser Ser 
    50                  55                  60                  


Phe Leu Ser Ile Asp Ser Gln Pro Gln Ala Ser Asn Ala Leu Glu Glu 
65                  70                  75                  80  


Leu Cys Phe Met Ile Met Gly Met Leu Pro Lys Pro Gln Glu Gln Asp 
                85                  90                  95      


Glu Lys Asp Asn Thr Lys Arg Phe Leu Phe His Tyr Ser Lys Thr Gln 
            100                 105                 110         


Lys Leu Gly Lys Ser Asn Val Val Ser Ser Val Val His Pro Leu Leu 
        115                 120                 125             


Gln Leu Val Pro His Leu His Glu Arg Arg Met Lys Arg Phe Arg Val 
    130                 135                 140                 


Asp Glu Glu Phe Gln Ser Pro Phe Ala Ser Gln Ser Arg Gly Tyr Phe 
145                 150                 155                 160 


Leu Phe Arg Pro Arg Asn Gly Arg Arg Ser Ala Gly Phe Ile 
                165                 170                 


<210>  9414
<211>  147
<212>  PRT
<213>  Homo Sapiens

<400>  9414

Met Leu Arg Thr Glu Ser Cys Arg Pro Arg Ser Pro Ala Gly Gln Val 
1               5                   10                  15      


Ala Ala Ala Ser Pro Leu Leu Leu Leu Leu Leu Leu Leu Ala Trp Cys 
            20                  25                  30          


Ala Gly Ala Cys Arg Gly Ala Pro Ile Leu Pro Gln Gly Leu Gln Pro 
        35                  40                  45              


Glu Gln Gln Leu Gln Leu Trp Asn Glu Ile Asp Asp Thr Cys Ser Ser 
    50                  55                  60                  


Phe Leu Ser Ile Asp Ser Gln Pro Gln Ala Ser Asn Ala Leu Glu Glu 
65                  70                  75                  80  


Leu Cys Phe Met Ile Met Gly Met Leu Pro Lys Pro Gln Ser Ser Val 
                85                  90                  95      


Val His Pro Leu Leu Gln Leu Val Pro His Leu His Glu Arg Arg Met 
            100                 105                 110         


Lys Arg Phe Arg Val Asp Glu Glu Phe Gln Ser Pro Phe Ala Ser Gln 
        115                 120                 125             


Ser Arg Gly Tyr Phe Leu Phe Arg Pro Arg Asn Gly Arg Arg Ser Ala 
    130                 135                 140                 


Gly Phe Ile 
145         


<210>  9415
<211>  698
<212>  PRT
<213>  Homo Sapiens

<400>  9415

Met Leu Pro Ala Arg Leu Pro Phe Arg Leu Leu Ser Leu Phe Leu Arg 
1               5                   10                  15      


Gly Ser Ala Pro Thr Ala Ala Arg His Gly Leu Arg Glu Pro Leu Leu 
            20                  25                  30          


Glu Arg Arg Cys Ala Ala Ala Ser Ser Phe Gln His Ser Ser Ser Leu 
        35                  40                  45              


Gly Arg Glu Leu Pro Tyr Asp Pro Val Asp Thr Glu Gly Phe Gly Glu 
    50                  55                  60                  


Gly Gly Asp Met Gln Glu Arg Phe Leu Phe Pro Glu Tyr Ile Leu Asp 
65                  70                  75                  80  


Pro Glu Pro Gln Pro Thr Arg Glu Lys Gln Leu Gln Glu Leu Gln Gln 
                85                  90                  95      


Gln Gln Glu Glu Glu Glu Arg Gln Arg Gln Gln Arg Arg Glu Glu Arg 
            100                 105                 110         


Arg Gln Gln Asn Leu Arg Ala Arg Ser Arg Glu His Pro Val Val Gly 
        115                 120                 125             


His Pro Asp Pro Ala Leu Pro Pro Ser Gly Val Asn Cys Ser Gly Cys 
    130                 135                 140                 


Gly Ala Glu Leu His Cys Gln Asp Ala Gly Val Pro Gly Tyr Leu Pro 
145                 150                 155                 160 


Arg Glu Lys Phe Leu Arg Thr Ala Glu Ala Asp Gly Gly Leu Ala Arg 
                165                 170                 175     


Thr Val Cys Gln Arg Cys Trp Leu Leu Ser His His Arg Arg Ala Leu 
            180                 185                 190         


Arg Leu Gln Val Ser Arg Glu Gln Tyr Leu Glu Leu Val Ser Ala Ala 
        195                 200                 205             


Leu Arg Arg Pro Gly Pro Ser Leu Val Leu Tyr Met Val Asp Leu Leu 
    210                 215                 220                 


Asp Leu Pro Asp Ala Leu Leu Pro Asp Leu Pro Ala Leu Val Gly Pro 
225                 230                 235                 240 


Lys Gln Leu Ile Val Leu Gly Asn Lys Val Asp Leu Leu Pro Gln Asp 
                245                 250                 255     


Ala Pro Gly Tyr Arg Gln Arg Leu Arg Glu Arg Leu Trp Glu Asp Cys 
            260                 265                 270         


Ala Arg Ala Gly Leu Leu Leu Ala Pro Gly His Gln Gly Pro Gln Arg 
        275                 280                 285             


Pro Val Lys Asp Glu Pro Gln Asp Gly Glu Asn Pro Asn Pro Pro Asn 
    290                 295                 300                 


Trp Ser Arg Thr Val Val Arg Asp Val Arg Leu Ile Ser Ala Lys Thr 
305                 310                 315                 320 


Gly Tyr Gly Val Glu Glu Leu Ile Ser Ala Leu Gln Arg Ser Trp Arg 
                325                 330                 335     


Tyr Arg Gly Asp Val Tyr Leu Val Gly Ala Thr Asn Ala Gly Lys Ser 
            340                 345                 350         


Thr Leu Phe Asn Thr Leu Leu Glu Ser Asp Tyr Cys Thr Ala Lys Gly 
        355                 360                 365             


Ser Glu Ala Ile Asp Arg Ala Thr Ile Ser Pro Trp Pro Gly Thr Thr 
    370                 375                 380                 


Leu Asn Leu Leu Lys Phe Pro Ile Cys Asn Pro Thr Pro Tyr Arg Met 
385                 390                 395                 400 


Phe Lys Arg His Gln Arg Leu Lys Lys Asp Ser Thr Gln Ala Glu Glu 
                405                 410                 415     


Asp Leu Ser Glu Gln Glu Gln Asn Gln Leu Asn Val Leu Lys Lys His 
            420                 425                 430         


Gly Tyr Val Val Gly Arg Val Gly Arg Thr Phe Leu Tyr Ser Glu Glu 
        435                 440                 445             


Gln Lys Asp Asn Ile Pro Phe Glu Phe Asp Ala Asp Ser Leu Ala Phe 
    450                 455                 460                 


Asp Met Glu Asn Asp Pro Val Met Gly Thr His Lys Ser Thr Lys Gln 
465                 470                 475                 480 


Val Glu Leu Thr Ala Gln Asp Val Lys Asp Ala His Trp Phe Tyr Asp 
                485                 490                 495     


Thr Pro Gly Ile Thr Lys Glu Asn Cys Ile Leu Asn Leu Leu Thr Glu 
            500                 505                 510         


Lys Glu Val Asn Ile Val Leu Pro Thr Gln Ser Ile Val Pro Arg Thr 
        515                 520                 525             


Phe Val Leu Lys Pro Gly Met Val Leu Phe Leu Gly Ala Ile Gly Arg 
    530                 535                 540                 


Ile Asp Phe Leu Gln Gly Asn Gln Ser Ala Trp Phe Thr Val Val Ala 
545                 550                 555                 560 


Ser Asn Ile Leu Pro Val His Ile Thr Ser Leu Asp Arg Ala Asp Ala 
                565                 570                 575     


Leu Tyr Gln Lys His Ala Gly His Thr Leu Leu Gln Ile Pro Met Gly 
            580                 585                 590         


Gly Lys Glu Arg Met Ala Gly Phe Pro Pro Leu Val Ala Glu Asp Ile 
        595                 600                 605             


Met Leu Lys Glu Gly Leu Gly Ala Ser Glu Ala Val Ala Asp Ile Lys 
    610                 615                 620                 


Phe Ser Ser Ala Gly Trp Val Ser Val Thr Pro Asn Phe Lys Asp Arg 
625                 630                 635                 640 


Leu His Leu Arg Gly Tyr Thr Pro Glu Gly Thr Val Leu Thr Val Arg 
                645                 650                 655     


Pro Pro Leu Leu Pro Tyr Ile Val Asn Ile Lys Gly Gln Arg Ile Lys 
            660                 665                 670         


Lys Ser Val Ala Tyr Lys Thr Lys Lys Pro Pro Ser Leu Met Tyr Asn 
        675                 680                 685             


Val Arg Lys Lys Lys Gly Lys Ile Asn Val 
    690                 695             


<210>  9416
<211>  292
<212>  PRT
<213>  Homo Sapiens

<400>  9416

Asp Gln Gln Leu Gly Ile Gln Thr Lys Asp Val Ala Val Asp Gly Gln 
1               5                   10                  15      


Asn Trp Thr Phe Ala Phe Asp Phe Ser Phe Leu Ser Gln Gln Glu Asp 
            20                  25                  30          


Leu Ala Trp Ala Glu Leu Arg Leu Gln Leu Ser Ser Pro Val Asp Leu 
        35                  40                  45              


Pro Thr Glu Gly Ser Leu Ala Ile Glu Ile Phe His Gln Pro Lys Pro 
    50                  55                  60                  


Asp Thr Glu Gln Ala Ser Asp Ser Cys Leu Glu Arg Phe Gln Met Asp 
65                  70                  75                  80  


Leu Phe Thr Val Thr Leu Ser Gln Val Thr Phe Ser Leu Gly Ser Met 
                85                  90                  95      


Val Leu Glu Val Thr Arg Pro Leu Ser Lys Trp Leu Lys His Pro Gly 
            100                 105                 110         


Ala Leu Glu Lys Gln Met Ser Arg Val Ala Gly Glu Cys Trp Pro Arg 
        115                 120                 125             


Pro Pro Thr Pro Pro Ala Thr Asn Val Leu Leu Met Leu Tyr Ser Asn 
    130                 135                 140                 


Leu Ser Gln Glu Gln Arg Gln Leu Gly Gly Ser Thr Leu Leu Trp Glu 
145                 150                 155                 160 


Ala Glu Ser Ser Trp Arg Ala Gln Glu Gly Gln Leu Ser Trp Glu Trp 
                165                 170                 175     


Gly Lys Arg His Arg Arg His His Leu Pro Asp Arg Ser Gln Leu Cys 
            180                 185                 190         


Arg Lys Val Lys Phe Gln Val Asp Phe Asn Leu Ile Gly Trp Gly Ser 
        195                 200                 205             


Trp Ile Ile Tyr Pro Lys Gln Tyr Asn Ala Tyr Arg Cys Glu Gly Glu 
    210                 215                 220                 


Cys Pro Asn Pro Val Gly Glu Glu Phe His Pro Thr Asn His Ala Tyr 
225                 230                 235                 240 


Ile Gln Ser Leu Leu Lys Arg Tyr Gln Pro His Arg Val Pro Ser Thr 
                245                 250                 255     


Cys Cys Ala Pro Val Lys Thr Lys Pro Leu Ser Met Leu Tyr Val Asp 
            260                 265                 270         


Asn Gly Arg Val Leu Leu Asp His His Lys Asp Met Ile Val Glu Glu 
        275                 280                 285             


Cys Gly Cys Leu 
    290         


<210>  9417
<211>  347
<212>  PRT
<213>  Homo Sapiens

<400>  9417

Met His Ala His Cys Leu Pro Phe Leu Leu His Ala Trp Trp Ala Leu 
1               5                   10                  15      


Leu Gln Ala Gly Ala Ala Thr Val Ala Thr Ala Leu Leu Arg Thr Arg 
            20                  25                  30          


Gly Gln Pro Ser Ser Pro Ser Pro Leu Ala Tyr Met Leu Ser Leu Tyr 
        35                  40                  45              


Arg Asp Pro Leu Pro Arg Ala Asp Ile Ile Arg Ser Leu Gln Ala Glu 
    50                  55                  60                  


Asp Val Ala Val Asp Gly Gln Asn Trp Thr Phe Ala Phe Asp Phe Ser 
65                  70                  75                  80  


Phe Leu Ser Gln Gln Glu Asp Leu Ala Trp Ala Glu Leu Arg Leu Gln 
                85                  90                  95      


Leu Ser Ser Pro Val Asp Leu Pro Thr Glu Gly Ser Leu Ala Ile Glu 
            100                 105                 110         


Ile Phe His Gln Pro Lys Pro Asp Thr Glu Gln Ala Ser Asp Ser Cys 
        115                 120                 125             


Leu Glu Arg Phe Gln Met Asp Leu Phe Thr Val Thr Leu Ser Gln Val 
    130                 135                 140                 


Thr Phe Ser Leu Gly Ser Met Val Leu Glu Val Thr Arg Pro Leu Ser 
145                 150                 155                 160 


Lys Trp Leu Lys His Pro Gly Ala Leu Glu Lys Gln Met Ser Arg Val 
                165                 170                 175     


Ala Gly Glu Cys Trp Pro Arg Pro Pro Thr Pro Pro Ala Thr Asn Val 
            180                 185                 190         


Leu Leu Met Leu Tyr Ser Asn Leu Ser Gln Glu Gln Arg Gln Leu Gly 
        195                 200                 205             


Gly Ser Thr Leu Leu Trp Glu Ala Glu Ser Ser Trp Arg Ala Gln Glu 
    210                 215                 220                 


Gly Gln Leu Ser Trp Glu Trp Gly Lys Arg His Arg Arg His His Leu 
225                 230                 235                 240 


Pro Asp Arg Ser Gln Leu Cys Arg Lys Val Lys Phe Gln Val Asp Phe 
                245                 250                 255     


Asn Leu Ile Gly Trp Gly Ser Trp Ile Ile Tyr Pro Lys Gln Tyr Asn 
            260                 265                 270         


Ala Tyr Arg Cys Glu Gly Glu Cys Pro Asn Pro Val Gly Glu Glu Phe 
        275                 280                 285             


His Pro Thr Asn His Ala Tyr Ile Gln Ser Leu Leu Lys Arg Tyr Gln 
    290                 295                 300                 


Pro His Arg Val Pro Ser Thr Cys Cys Ala Pro Val Lys Thr Lys Pro 
305                 310                 315                 320 


Leu Ser Met Leu Tyr Val Asp Asn Gly Arg Val Leu Leu Asp His His 
                325                 330                 335     


Lys Asp Met Ile Val Glu Glu Cys Gly Cys Leu 
            340                 345         


<210>  9418
<211>  232
<212>  PRT
<213>  Homo Sapiens

<400>  9418

Met Glu Arg Cys Pro Ser Leu Gly Val Thr Leu Tyr Ala Leu Val Val 
1               5                   10                  15      


Val Leu Gly Leu Arg Ala Thr Pro Ala Gly Gly Gln His Tyr Leu His 
            20                  25                  30          


Ile Arg Pro Ala Pro Ser Asp Asn Leu Pro Leu Val Asp Leu Ile Glu 
        35                  40                  45              


His Pro Asp Pro Ile Phe Asp Pro Lys Glu Lys Asp Leu Asn Glu Thr 
    50                  55                  60                  


Leu Leu Arg Ser Leu Leu Gly Gly His Tyr Asp Pro Gly Phe Met Ala 
65                  70                  75                  80  


Thr Ser Pro Pro Glu Asp Arg Pro Gly Gly Gly Gly Gly Ala Ala Gly 
                85                  90                  95      


Gly Ala Glu Asp Leu Ala Glu Leu Asp Gln Leu Leu Arg Gln Arg Pro 
            100                 105                 110         


Ser Gly Ala Met Pro Ser Glu Ile Lys Gly Leu Glu Phe Ser Glu Gly 
        115                 120                 125             


Leu Ala Gln Gly Lys Lys Gln Arg Leu Ser Lys Lys Leu Arg Arg Lys 
    130                 135                 140                 


Leu Gln Met Trp Leu Trp Ser Gln Thr Phe Cys Pro Val Leu Tyr Ala 
145                 150                 155                 160 


Trp Asn Asp Leu Gly Ser Arg Phe Trp Pro Arg Tyr Val Lys Val Gly 
                165                 170                 175     


Ser Cys Phe Ser Lys Arg Ser Cys Ser Val Pro Glu Gly Met Val Cys 
            180                 185                 190         


Lys Pro Ser Lys Ser Val His Leu Thr Val Leu Arg Trp Arg Cys Gln 
        195                 200                 205             


Arg Arg Gly Gly Gln Arg Cys Gly Trp Ile Pro Ile Gln Tyr Pro Ile 
    210                 215                 220                 


Ile Ser Glu Cys Lys Cys Ser Cys 
225                 230         


<210>  9419
<211>  138
<212>  PRT
<213>  Homo Sapiens

<400>  9419

Met Leu Val Gly Gln Gly Ala Gly Pro Leu Gly Pro Ala Val Val Thr 
1               5                   10                  15      


Ala Ala Val Val Leu Leu Leu Ser Gly Val Gly Pro Ala His Gly Ser 
            20                  25                  30          


Glu Asp Ile Val Val Gly Cys Gly Gly Phe Val Lys Ser Asp Val Glu 
        35                  40                  45              


Ile Asn Tyr Ser Leu Ile Glu Ile Lys Leu Tyr Thr Lys His Gly Thr 
    50                  55                  60                  


Leu Lys Tyr Gln Thr Asp Cys Ala Pro Asn Asn Gly Tyr Phe Met Ile 
65                  70                  75                  80  


Pro Leu Tyr Asp Lys Gly Asp Phe Ile Leu Lys Ile Glu Pro Pro Leu 
                85                  90                  95      


Gly Trp Ser Phe Glu Pro Thr Thr Val Glu Leu His Val Asp Gly Val 
            100                 105                 110         


Ser Asp Ile Cys Thr Lys Gly Gly Asp Ile Asn Phe Val Phe Thr Gly 
        115                 120                 125             


Phe Ser Val Asn Gly Lys Val Cys Ile Phe 
    130                 135             


<210>  9420
<211>  1267
<212>  PRT
<213>  Homo Sapiens

<400>  9420

Met Leu Val Gly Gln Gly Ala Gly Pro Leu Gly Pro Ala Val Val Thr 
1               5                   10                  15      


Ala Ala Val Val Leu Leu Leu Ser Gly Val Gly Pro Ala His Gly Ser 
            20                  25                  30          


Glu Asp Ile Val Val Gly Cys Gly Gly Phe Val Lys Ser Asp Val Glu 
        35                  40                  45              


Ile Asn Tyr Ser Leu Ile Glu Ile Lys Leu Tyr Thr Lys His Gly Thr 
    50                  55                  60                  


Leu Lys Tyr Gln Thr Asp Cys Ala Pro Asn Asn Gly Tyr Phe Met Ile 
65                  70                  75                  80  


Pro Leu Tyr Asp Lys Gly Asp Phe Ile Leu Lys Ile Glu Pro Pro Leu 
                85                  90                  95      


Gly Trp Ser Phe Glu Pro Thr Thr Val Glu Leu His Val Asp Gly Val 
            100                 105                 110         


Ser Asp Ile Cys Thr Lys Gly Gly Asp Ile Asn Phe Val Phe Thr Gly 
        115                 120                 125             


Phe Ser Val Asn Gly Lys Val Leu Ser Lys Gly Gln Pro Leu Gly Pro 
    130                 135                 140                 


Ala Gly Val Gln Val Ser Leu Arg Asn Thr Gly Thr Glu Ala Lys Ile 
145                 150                 155                 160 


Gln Ser Thr Val Thr Gln Pro Gly Gly Lys Phe Ala Phe Phe Lys Val 
                165                 170                 175     


Leu Pro Gly Asp Tyr Glu Ile Leu Ala Thr His Pro Thr Trp Ala Leu 
            180                 185                 190         


Lys Glu Ala Ser Thr Thr Val Arg Val Thr Asn Ser Asn Ala Asn Ala 
        195                 200                 205             


Ala Ser Pro Leu Ile Val Ala Gly Tyr Asn Val Ser Gly Ser Val Arg 
    210                 215                 220                 


Ser Asp Gly Glu Pro Met Lys Gly Val Lys Phe Leu Leu Phe Ser Ser 
225                 230                 235                 240 


Leu Val Thr Lys Glu Asp Val Leu Gly Cys Asn Val Ser Pro Val Pro 
                245                 250                 255     


Gly Phe Gln Pro Gln Asp Glu Ser Leu Val Tyr Leu Cys Tyr Thr Val 
            260                 265                 270         


Ser Arg Glu Asp Gly Ser Phe Ser Phe Tyr Ser Leu Pro Ser Gly Gly 
        275                 280                 285             


Tyr Thr Val Ile Pro Phe Tyr Arg Gly Glu Arg Ile Thr Phe Asp Val 
    290                 295                 300                 


Ala Pro Ser Arg Leu Asp Phe Thr Val Glu His Asp Ser Leu Lys Ile 
305                 310                 315                 320 


Glu Pro Val Phe His Val Met Gly Phe Ser Val Thr Gly Arg Val Leu 
                325                 330                 335     


Asn Gly Pro Glu Gly Asp Gly Val Pro Glu Ala Val Val Thr Leu Asn 
            340                 345                 350         


Asn Gln Ile Lys Val Lys Thr Lys Ala Asp Gly Ser Phe Arg Leu Glu 
        355                 360                 365             


Asn Ile Thr Thr Gly Thr Tyr Thr Ile His Ala Gln Lys Glu His Leu 
    370                 375                 380                 


Tyr Phe Glu Thr Val Thr Ile Lys Ile Ala Pro Asn Thr Pro Gln Leu 
385                 390                 395                 400 


Ala Asp Ile Val Ala Thr Gly Phe Ser Val Cys Gly Gln Ile Ser Ile 
                405                 410                 415     


Ile Arg Phe Pro Asp Thr Val Lys Gln Met Asn Lys Tyr Lys Val Val 
            420                 425                 430         


Leu Ser Ser Gln Asp Lys Asp Lys Ser Leu Val Thr Val Glu Thr Asp 
        435                 440                 445             


Ala His Gly Ser Phe Cys Phe Lys Ala Asn Pro Gly Thr Tyr Lys Val 
    450                 455                 460                 


Gln Val Met Val Pro Glu Ala Glu Thr Arg Ala Gly Leu Thr Leu Lys 
465                 470                 475                 480 


Pro Gln Thr Phe Pro Leu Thr Val Thr Asp Arg Pro Val Met Asp Val 
                485                 490                 495     


Ala Phe Val Gln Phe Leu Ala Ser Val Ser Gly Lys Val Ser Cys Leu 
            500                 505                 510         


Asp Thr Cys Gly Asp Leu Leu Val Thr Leu Gln Ser Leu Ser Arg Gln 
        515                 520                 525             


Gly Glu Lys Arg Ser Leu Gln Leu Ser Gly Lys Val Asn Ala Met Thr 
    530                 535                 540                 


Phe Thr Phe Asp Asn Val Leu Pro Gly Lys Tyr Lys Ile Ser Ile Met 
545                 550                 555                 560 


His Glu Asp Trp Cys Trp Lys Asn Lys Ser Leu Glu Val Glu Val Leu 
                565                 570                 575     


Glu Asp Asp Val Ser Ala Val Glu Phe Arg Gln Thr Gly Tyr Met Leu 
            580                 585                 590         


Arg Cys Ser Leu Ser His Ala Ile Thr Leu Glu Phe Tyr Gln Asp Gly 
        595                 600                 605             


Asn Gly Arg Glu Asn Val Gly Ile Tyr Asn Leu Ser Lys Gly Val Asn 
    610                 615                 620                 


Arg Phe Cys Leu Ser Lys Pro Gly Val Tyr Lys Val Thr Pro Arg Ser 
625                 630                 635                 640 


Cys His Arg Phe Glu Gln Ala Phe Tyr Thr Tyr Asp Thr Ser Ser Pro 
                645                 650                 655     


Ser Ile Leu Thr Leu Thr Ala Ile Arg His His Val Leu Gly Thr Ile 
            660                 665                 670         


Thr Thr Asp Lys Met Met Asp Val Thr Val Thr Ile Lys Ser Ser Ile 
        675                 680                 685             


Asp Ser Glu Pro Ala Leu Val Leu Gly Pro Leu Lys Ser Val Gln Glu 
    690                 695                 700                 


Leu Arg Arg Glu Gln Gln Leu Ala Glu Ile Glu Ala Arg Arg Gln Glu 
705                 710                 715                 720 


Arg Glu Lys Asn Gly Asn Glu Glu Gly Glu Glu Arg Met Thr Lys Pro 
                725                 730                 735     


Pro Val Gln Glu Met Val Asp Glu Leu Gln Gly Pro Phe Ser Tyr Asp 
            740                 745                 750         


Phe Ser Tyr Trp Ala Arg Ser Gly Glu Lys Ile Thr Val Thr Pro Ser 
        755                 760                 765             


Ser Lys Glu Leu Leu Phe Tyr Pro Pro Ser Met Glu Ala Val Val Ser 
    770                 775                 780                 


Gly Glu Ser Cys Pro Gly Lys Leu Ile Glu Ile His Gly Lys Ala Gly 
785                 790                 795                 800 


Leu Phe Leu Glu Gly Gln Ile His Pro Glu Leu Glu Gly Val Glu Ile 
                805                 810                 815     


Val Ile Ser Glu Lys Gly Ala Ser Ser Pro Leu Ile Thr Val Phe Thr 
            820                 825                 830         


Asp Asp Lys Gly Ala Tyr Ser Val Gly Pro Leu His Ser Asp Leu Glu 
        835                 840                 845             


Tyr Thr Val Thr Ser Gln Lys Glu Gly Tyr Val Leu Thr Ala Val Glu 
    850                 855                 860                 


Gly Thr Ile Gly Asp Phe Lys Ala Tyr Ala Leu Ala Gly Val Ser Phe 
865                 870                 875                 880 


Glu Ile Lys Ala Glu Asp Asp Gln Pro Leu Pro Gly Val Leu Leu Ser 
                885                 890                 895     


Leu Ser Gly Gly Leu Phe Arg Ser Asn Leu Leu Thr Gln Asp Asn Gly 
            900                 905                 910         


Ile Leu Thr Phe Ser Asn Leu Ser Pro Gly Gln Tyr Tyr Phe Lys Pro 
        915                 920                 925             


Met Met Lys Glu Phe Arg Phe Glu Pro Ser Ser Gln Met Ile Glu Val 
    930                 935                 940                 


Gln Glu Gly Gln Asn Leu Lys Ile Thr Ile Thr Gly Tyr Arg Thr Ala 
945                 950                 955                 960 


Tyr Ser Cys Tyr Gly Thr Val Ser Ser Leu Asn Gly Glu Pro Glu Gln 
                965                 970                 975     


Gly Val Ala Met Glu Ala Val Gly Gln Asn Asp Cys Ser Ile Tyr Gly 
            980                 985                 990         


Glu Asp Thr Val Thr Asp Glu Glu  Gly Lys Phe Arg Leu  Arg Gly Leu 
        995                 1000                 1005             


Leu Pro  Gly Cys Val Tyr His  Val Gln Leu Lys Ala  Glu Gly Asn 
    1010                 1015                 1020             


Asp His  Ile Glu Arg Ala Leu  Pro His His Arg Val  Ile Glu Val 
    1025                 1030                 1035             


Gly Asn  Asn Asp Ile Asp Asp  Val Asn Ile Ile Val  Phe Arg Gln 
    1040                 1045                 1050             


Ile Asn  Gln Phe Asp Leu Ser  Gly Asn Val Ile Thr  Ser Ser Glu 
    1055                 1060                 1065             


Tyr Leu  Pro Thr Leu Trp Val  Lys Leu Tyr Lys Ser  Glu Asn Leu 
    1070                 1075                 1080             


Asp Asn  Pro Ile Gln Thr Val  Ser Leu Gly Gln Ser  Leu Phe Phe 
    1085                 1090                 1095             


His Phe  Pro Pro Leu Leu Arg  Asp Gly Glu Asn Tyr  Val Val Leu 
    1100                 1105                 1110             


Leu Asp  Ser Thr Leu Pro Arg  Ser Gln Tyr Asp Tyr  Ile Leu Pro 
    1115                 1120                 1125             


Gln Val  Ser Phe Thr Ala Val  Gly Tyr His Lys His  Ile Thr Leu 
    1130                 1135                 1140             


Ile Phe  Asn Pro Thr Arg Lys  Leu Pro Glu Gln Asp  Ile Ala Gln 
    1145                 1150                 1155             


Gly Ser  Tyr Ile Ala Leu Pro  Leu Thr Leu Leu Val  Leu Leu Ala 
    1160                 1165                 1170             


Gly Tyr  Asn His Asp Lys Leu  Ile Pro Leu Leu Leu  Gln Leu Thr 
    1175                 1180                 1185             


Ser Arg  Leu Gln Gly Val Gly  Ala Leu Gly Gln Ala  Ala Ser Asp 
    1190                 1195                 1200             


Asn Ser  Gly Pro Glu Asp Ala  Lys Arg Gln Ala Lys  Lys Gln Lys 
    1205                 1210                 1215             


Thr Arg  Arg Thr Leu Arg Leu  Gln Glu Glu Phe Gln  Leu Met Trp 
    1220                 1225                 1230             


Cys Leu  Val Pro Trp Arg Gly  Thr Leu Gly Ile His  Leu Phe Ser 
    1235                 1240                 1245             


Ser Leu  Pro Phe Ala Ser Glu  Ile Leu Leu Glu Thr  Thr Ala Thr 
    1250                 1255                 1260             


Cys Ile  His Tyr 
    1265         


<210>  9421
<211>  1222
<212>  PRT
<213>  Homo Sapiens

<400>  9421

Met Leu Val Gly Gln Gly Ala Gly Pro Leu Gly Pro Ala Val Val Thr 
1               5                   10                  15      


Ala Ala Val Val Leu Leu Leu Ser Gly Val Gly Pro Ala His Gly Ser 
            20                  25                  30          


Glu Asp Ile Val Val Gly Cys Gly Gly Phe Val Lys Ser Asp Val Glu 
        35                  40                  45              


Ile Asn Tyr Ser Leu Ile Glu Ile Lys Leu Tyr Thr Lys His Gly Thr 
    50                  55                  60                  


Leu Lys Tyr Gln Thr Asp Cys Ala Pro Asn Asn Gly Tyr Phe Met Ile 
65                  70                  75                  80  


Pro Leu Tyr Asp Lys Gly Asp Phe Ile Leu Lys Ile Glu Pro Pro Leu 
                85                  90                  95      


Gly Trp Ser Phe Glu Pro Thr Thr Val Glu Leu His Val Asp Gly Val 
            100                 105                 110         


Ser Asp Ile Cys Thr Lys Gly Gly Asp Ile Asn Phe Val Phe Thr Gly 
        115                 120                 125             


Phe Ser Val Asn Gly Lys Val Leu Ser Lys Gly Gln Pro Leu Gly Pro 
    130                 135                 140                 


Ala Gly Val Gln Val Ser Leu Arg Asn Thr Gly Thr Glu Ala Lys Ile 
145                 150                 155                 160 


Gln Ser Thr Val Thr Gln Pro Gly Gly Lys Phe Ala Phe Phe Lys Val 
                165                 170                 175     


Leu Pro Gly Asp Tyr Glu Ile Leu Ala Thr His Pro Thr Trp Ala Leu 
            180                 185                 190         


Lys Glu Ala Ser Thr Thr Val Arg Val Thr Asn Ser Asn Ala Asn Ala 
        195                 200                 205             


Ala Ser Pro Leu Ile Val Ala Gly Tyr Asn Val Ser Gly Ser Val Arg 
    210                 215                 220                 


Ser Asp Gly Glu Pro Met Lys Gly Val Lys Phe Leu Leu Phe Ser Ser 
225                 230                 235                 240 


Leu Val Thr Lys Glu Asp Val Leu Gly Cys Asn Val Ser Pro Val Pro 
                245                 250                 255     


Gly Phe Gln Pro Gln Asp Glu Ser Leu Val Tyr Leu Cys Tyr Thr Val 
            260                 265                 270         


Ser Arg Glu Asp Gly Ser Phe Ser Phe Tyr Ser Leu Pro Ser Gly Gly 
        275                 280                 285             


Tyr Thr Val Ile Pro Phe Tyr Arg Gly Glu Arg Ile Thr Phe Asp Val 
    290                 295                 300                 


Ala Pro Ser Arg Leu Asp Phe Thr Val Glu His Asp Ser Leu Lys Ile 
305                 310                 315                 320 


Glu Pro Val Phe His Val Met Gly Phe Ser Val Thr Gly Arg Val Leu 
                325                 330                 335     


Asn Gly Pro Glu Gly Asp Gly Val Pro Glu Ala Val Val Thr Leu Asn 
            340                 345                 350         


Asn Gln Ile Lys Val Lys Thr Lys Ala Asp Gly Ser Phe Arg Leu Glu 
        355                 360                 365             


Asn Ile Thr Thr Gly Thr Tyr Thr Ile His Ala Gln Lys Glu His Leu 
    370                 375                 380                 


Tyr Phe Glu Thr Val Thr Ile Lys Ile Ala Pro Asn Thr Pro Gln Leu 
385                 390                 395                 400 


Ala Asp Ile Val Ala Thr Gly Phe Ser Val Cys Gly Gln Ile Ser Ile 
                405                 410                 415     


Ile Arg Phe Pro Asp Thr Val Lys Gln Met Asn Lys Tyr Lys Val Val 
            420                 425                 430         


Leu Ser Ser Gln Asp Lys Asp Lys Ser Leu Val Thr Val Glu Thr Asp 
        435                 440                 445             


Ala His Gly Ser Phe Cys Phe Lys Ala Asn Pro Gly Thr Tyr Lys Val 
    450                 455                 460                 


Gln Val Met Val Pro Glu Ala Glu Thr Arg Ala Gly Leu Thr Leu Lys 
465                 470                 475                 480 


Pro Gln Thr Phe Pro Leu Thr Val Thr Asp Arg Pro Val Met Asp Val 
                485                 490                 495     


Ala Phe Val Gln Phe Leu Ala Ser Val Ser Gly Lys Val Ser Cys Leu 
            500                 505                 510         


Asp Thr Cys Gly Asp Leu Leu Val Thr Leu Gln Ser Leu Ser Arg Gln 
        515                 520                 525             


Gly Glu Lys Arg Ser Leu Gln Leu Ser Gly Lys Val Asn Ala Met Thr 
    530                 535                 540                 


Phe Thr Phe Asp Asn Val Leu Pro Gly Lys Tyr Lys Ile Ser Ile Met 
545                 550                 555                 560 


His Glu Asp Trp Cys Trp Lys Asn Lys Ser Leu Glu Val Glu Val Leu 
                565                 570                 575     


Glu Asp Asp Val Ser Ala Val Glu Phe Arg Gln Thr Gly Tyr Met Leu 
            580                 585                 590         


Arg Cys Ser Leu Ser His Ala Ile Thr Leu Glu Phe Tyr Gln Asp Gly 
        595                 600                 605             


Asn Gly Arg Glu Asn Val Gly Ile Tyr Asn Leu Ser Lys Gly Val Asn 
    610                 615                 620                 


Arg Phe Cys Leu Ser Lys Pro Gly Val Tyr Lys Val Thr Pro Arg Ser 
625                 630                 635                 640 


Cys His Arg Phe Glu Gln Ala Phe Tyr Thr Tyr Asp Thr Ser Ser Pro 
                645                 650                 655     


Ser Ile Leu Thr Leu Thr Ala Ile Arg His His Val Leu Gly Thr Ile 
            660                 665                 670         


Thr Thr Asp Lys Met Met Asp Val Thr Val Thr Ile Lys Ser Ser Ile 
        675                 680                 685             


Asp Ser Glu Pro Ala Leu Val Leu Gly Pro Leu Lys Ser Val Gln Glu 
    690                 695                 700                 


Leu Arg Arg Glu Gln Gln Leu Ala Glu Ile Glu Ala Arg Arg Gln Glu 
705                 710                 715                 720 


Arg Glu Lys Asn Gly Asn Glu Glu Gly Glu Glu Arg Met Thr Lys Pro 
                725                 730                 735     


Pro Val Gln Glu Met Val Asp Glu Leu Gln Gly Pro Phe Ser Tyr Asp 
            740                 745                 750         


Phe Ser Tyr Trp Ala Arg Ser Gly Glu Lys Ile Thr Val Thr Pro Ser 
        755                 760                 765             


Ser Lys Glu Leu Leu Phe Tyr Pro Pro Ser Met Glu Ala Val Val Ser 
    770                 775                 780                 


Gly Glu Ser Cys Pro Gly Lys Leu Ile Glu Ile His Gly Lys Ala Gly 
785                 790                 795                 800 


Leu Phe Leu Glu Gly Gln Ile His Pro Glu Leu Glu Gly Val Glu Ile 
                805                 810                 815     


Val Ile Ser Glu Lys Gly Ala Ser Ser Pro Leu Ile Thr Val Phe Thr 
            820                 825                 830         


Asp Asp Lys Gly Ala Tyr Ser Val Gly Pro Leu His Ser Asp Leu Glu 
        835                 840                 845             


Tyr Thr Val Thr Ser Gln Lys Glu Gly Tyr Val Leu Thr Ala Val Glu 
    850                 855                 860                 


Gly Thr Ile Gly Asp Phe Lys Ala Tyr Ala Leu Ala Gly Val Ser Phe 
865                 870                 875                 880 


Glu Ile Lys Ala Glu Asp Asp Gln Pro Leu Pro Gly Val Leu Leu Ser 
                885                 890                 895     


Leu Ser Gly Gly Leu Phe Arg Ser Asn Leu Leu Thr Gln Asp Asn Gly 
            900                 905                 910         


Ile Leu Thr Phe Ser Asn Leu Ser Pro Gly Gln Tyr Tyr Phe Lys Pro 
        915                 920                 925             


Met Met Lys Glu Phe Arg Phe Glu Pro Ser Ser Gln Met Ile Glu Val 
    930                 935                 940                 


Gln Glu Gly Gln Asn Leu Lys Ile Thr Ile Thr Gly Tyr Arg Thr Ala 
945                 950                 955                 960 


Tyr Ser Cys Tyr Gly Thr Val Ser Ser Leu Asn Gly Glu Pro Glu Gln 
                965                 970                 975     


Gly Val Ala Met Glu Ala Val Gly Gln Asn Asp Cys Ser Ile Tyr Gly 
            980                 985                 990         


Glu Asp Thr Val Thr Asp Glu Glu  Gly Lys Phe Arg Leu  Arg Gly Leu 
        995                 1000                 1005             


Leu Pro  Gly Cys Val Tyr His  Val Gln Leu Lys Ala  Glu Gly Asn 
    1010                 1015                 1020             


Asp His  Ile Glu Arg Ala Leu  Pro His His Arg Val  Ile Glu Val 
    1025                 1030                 1035             


Gly Asn  Asn Asp Ile Asp Asp  Val Asn Ile Ile Val  Phe Arg Gln 
    1040                 1045                 1050             


Ile Asn  Gln Phe Asp Leu Ser  Gly Asn Val Ile Thr  Ser Ser Glu 
    1055                 1060                 1065             


Tyr Leu  Pro Thr Leu Trp Val  Lys Leu Tyr Lys Ser  Glu Asn Leu 
    1070                 1075                 1080             


Asp Asn  Pro Ile Gln Thr Val  Ser Leu Gly Gln Ser  Leu Phe Phe 
    1085                 1090                 1095             


His Phe  Pro Pro Leu Leu Arg  Asp Gly Glu Asn Tyr  Val Val Leu 
    1100                 1105                 1110             


Leu Asp  Ser Thr Leu Pro Arg  Ser Gln Tyr Asp Tyr  Ile Leu Pro 
    1115                 1120                 1125             


Gln Val  Ser Phe Thr Ala Val  Gly Tyr His Lys His  Ile Thr Leu 
    1130                 1135                 1140             


Ile Phe  Asn Pro Thr Arg Lys  Leu Pro Glu Gln Asp  Ile Ala Gln 
    1145                 1150                 1155             


Gly Ser  Tyr Ile Ala Leu Pro  Leu Thr Leu Leu Val  Leu Leu Ala 
    1160                 1165                 1170             


Gly Tyr  Asn His Asp Lys Leu  Ile Pro Leu Leu Leu  Gln Leu Thr 
    1175                 1180                 1185             


Ser Arg  Leu Gln Gly Val Gly  Ala Leu Gly Gln Ala  Ala Ser Asp 
    1190                 1195                 1200             


Asn Ser  Gly Pro Glu Asp Ala  Lys Arg Gln Ala Lys  Lys Gln Lys 
    1205                 1210                 1215             


Thr Arg  Arg Thr 
    1220         


<210>  9422
<211>  61
<212>  PRT
<213>  Homo Sapiens

<400>  9422

Met Leu Val Gly Gln Gly Ala Gly Pro Leu Gly Pro Ala Val Val Thr 
1               5                   10                  15      


Ala Ala Val Val Leu Leu Leu Ser Gly Val Gly Pro Ala His Gly Ser 
            20                  25                  30          


Glu Asp Ile Val Val Gly Cys Gly Gly Phe Val Lys Ser Asp Val Glu 
        35                  40                  45              


Ile Asn Tyr Ser Leu Ile Glu Gln Val Leu Asn Met His 
    50                  55                  60      


<210>  9423
<211>  95
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9423

Xaa Glu Asp Trp Cys Trp Lys Asn Lys Ser Leu Glu Val Glu Val Leu 
1               5                   10                  15      


Glu Asp Asp Val Ser Ala Val Glu Phe Arg Gln Thr Gly Tyr Met Leu 
            20                  25                  30          


Arg Cys Ser Leu Ser His Ala Ile Thr Leu Val Gln Pro Tyr Cys Ser 
        35                  40                  45              


Gly Glu Met Cys Pro Gly Thr Ser Glu Leu Lys Thr Pro Arg Asn Phe 
    50                  55                  60                  


Ile Arg Met Glu Met Gly Val Arg Met Trp Gly Phe Ile Thr Ser Pro 
65                  70                  75                  80  


Lys Glu Ser Thr Asp Ser Ala Cys Pro Ser Leu Val Cys Thr Lys 
                85                  90                  95  


<210>  9424
<211>  50
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9424

Xaa Ser Tyr Ile Ala Leu Pro Leu Thr Leu Leu Val Leu Leu Ala Gly 
1               5                   10                  15      


Tyr Asn His Asp Lys Gly His Ile Arg Pro Gly Glu Arg Pro Ala His 
            20                  25                  30          


Pro Trp Gly Leu Ile Ser Lys Arg Pro Ala Ser Phe Glu Leu Lys Pro 
        35                  40                  45              


Thr His 
    50  


<210>  9425
<211>  80
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9425

Xaa Thr Gly Tyr Met Leu Arg Cys Ser Leu Ser His Ala Ile Thr Leu 
1               5                   10                  15      


Val Cys Thr Ala Tyr Gly Val Ser Tyr Leu Glu Lys Arg Leu Pro Cys 
            20                  25                  30          


Gly Cys Gln Glu Arg Leu Thr Ser Gln Glu Tyr Cys Lys Arg Arg Asn 
        35                  40                  45              


Phe Ile Arg Met Glu Met Gly Val Arg Met Trp Gly Phe Ile Thr Ser 
    50                  55                  60                  


Pro Lys Glu Ser Thr Asp Ser Ala Cys Pro Ser Leu Val Cys Thr Lys 
65                  70                  75                  80  


<210>  9426
<211>  81
<212>  PRT
<213>  Homo Sapiens

<400>  9426

Met Leu Gln His Ile Ser Leu Leu Val Lys Gln Val Gln Glu Leu Glu 
1               5                   10                  15      


Leu Lys Leu Ser Gly Gln Asn Ala Met Gly Ser Gln Asp Ser Leu Leu 
            20                  25                  30          


Glu Ile Thr Phe Arg Ser Gly Ala Leu Pro Val Leu Cys Asp Pro Thr 
        35                  40                  45              


Thr Pro Lys Pro Glu Asp Leu His Ser Pro Pro Leu Gly Ala Gly Leu 
    50                  55                  60                  


Ala Asp Phe Ala His Pro Ala Gly Ser Pro Leu Gly Arg Arg Asp Cys 
65                  70                  75                  80  


Leu 
    


<210>  9427
<211>  349
<212>  PRT
<213>  Homo Sapiens

<400>  9427

Met Pro Ser Lys Thr Lys Tyr Asn Leu Val Asp Asp Gly His Asp Leu 
1               5                   10                  15      


Arg Ile Pro Leu His Asn Glu Asp Ala Phe Gln His Gly Ile Cys Phe 
            20                  25                  30          


Glu Ala Lys Tyr Val Gly Ser Leu Asp Val Pro Arg Pro Asn Ser Arg 
        35                  40                  45              


Val Glu Ile Val Ala Ala Met Arg Arg Ile Arg Tyr Glu Phe Lys Ala 
    50                  55                  60                  


Lys Asn Ile Lys Lys Lys Lys Val Ser Ile Met Val Ser Val Asp Gly 
65                  70                  75                  80  


Val Lys Val Ile Leu Lys Lys Lys Lys Lys Lys Lys Glu Trp Thr Trp 
                85                  90                  95      


Asp Glu Ser Lys Met Leu Val Met Gln Asp Pro Ile Tyr Arg Ile Phe 
            100                 105                 110         


Tyr Val Ser His Asp Ser Gln Asp Leu Lys Ile Phe Ser Tyr Ile Ala 
        115                 120                 125             


Arg Asp Gly Ala Ser Asn Ile Phe Arg Cys Asn Val Phe Lys Ser Lys 
    130                 135                 140                 


Lys Lys Ser Gln Ala Met Arg Ile Val Arg Thr Val Gly Gln Ala Phe 
145                 150                 155                 160 


Glu Val Cys His Lys Leu Ser Leu Gln His Thr Gln Gln Asn Ala Asp 
                165                 170                 175     


Gly Gln Glu Asp Gly Glu Ser Glu Arg Asn Ser Asn Ser Ser Gly Asp 
            180                 185                 190         


Pro Gly Arg Gln Leu Thr Gly Ala Glu Arg Ala Ser Thr Ala Thr Ala 
        195                 200                 205             


Glu Glu Thr Asp Ile Asp Ala Val Glu Val Pro Leu Pro Gly Asn Asp 
    210                 215                 220                 


Val Leu Glu Phe Ser Arg Gly Val Thr Asp Leu Asp Ala Val Gly Lys 
225                 230                 235                 240 


Glu Gly Gly Ser His Thr Gly Ser Lys Val Ser His Pro Gln Glu Pro 
                245                 250                 255     


Met Leu Thr Ala Ser Pro Arg Met Leu Leu Pro Ser Ser Ser Ser Lys 
            260                 265                 270         


Pro Pro Gly Leu Gly Thr Glu Thr Pro Leu Ser Thr His His Gln Met 
        275                 280                 285             


Gln Leu Leu Gln Gln Leu Leu Gln Gln Gln Gln Gln Gln Thr Gln Val 
    290                 295                 300                 


Ala Val Ala Gln Cys Val Val Gly Gln Ile Ala Leu Val Leu Ser Thr 
305                 310                 315                 320 


Ala Ile Ser Met Cys Leu Leu Leu Pro Asn Phe Ser Leu Ala Leu Pro 
                325                 330                 335     


Ser Leu Leu Met Glu Glu Leu Glu Ser Arg Tyr Thr Cys 
            340                 345                 


<210>  9428
<211>  501
<212>  PRT
<213>  Homo Sapiens

<400>  9428

Met Pro Ser Lys Thr Lys Tyr Asn Leu Val Asp Asp Gly His Asp Leu 
1               5                   10                  15      


Arg Ile Pro Leu His Asn Glu Asp Ala Phe Gln His Gly Ile Cys Phe 
            20                  25                  30          


Glu Ala Lys Tyr Val Gly Ser Leu Asp Val Pro Arg Pro Asn Ser Arg 
        35                  40                  45              


Val Glu Ile Val Ala Ala Met Arg Arg Ile Arg Tyr Glu Phe Lys Ala 
    50                  55                  60                  


Lys Asn Ile Lys Lys Lys Lys Val Ser Ile Met Val Ser Val Asp Gly 
65                  70                  75                  80  


Val Lys Val Ile Leu Lys Lys Lys Lys Lys Lys Lys Glu Trp Thr Trp 
                85                  90                  95      


Asp Glu Ser Lys Met Leu Val Met Gln Asp Pro Ile Tyr Arg Ile Phe 
            100                 105                 110         


Tyr Val Ser His Asp Ser Gln Asp Leu Lys Ile Phe Ser Tyr Ile Ala 
        115                 120                 125             


Arg Asp Gly Ala Ser Asn Ile Phe Arg Cys Asn Val Phe Lys Ser Lys 
    130                 135                 140                 


Lys Lys Ser Gln Ala Met Arg Ile Val Arg Thr Val Gly Gln Ala Phe 
145                 150                 155                 160 


Glu Val Cys His Lys Leu Ser Leu Gln His Thr Gln Gln Asn Ala Asp 
                165                 170                 175     


Gly Gln Glu Asp Gly Glu Ser Glu Arg Asn Ser Asn Ser Ser Gly Asp 
            180                 185                 190         


Pro Gly Arg Gln Leu Thr Gly Ala Glu Arg Ala Ser Thr Ala Thr Ala 
        195                 200                 205             


Glu Glu Thr Asp Ile Asp Ala Val Glu Val Pro Leu Pro Gly Asn Asp 
    210                 215                 220                 


Val Leu Glu Phe Ser Arg Gly Val Thr Asp Leu Asp Ala Val Gly Lys 
225                 230                 235                 240 


Glu Gly Gly Ser His Thr Gly Ser Lys Val Ser His Pro Gln Glu Pro 
                245                 250                 255     


Met Leu Thr Ala Ser Pro Arg Met Leu Leu Pro Ser Ser Ser Ser Lys 
            260                 265                 270         


Pro Pro Gly Leu Gly Thr Glu Thr Pro Leu Ser Thr His His Gln Met 
        275                 280                 285             


Gln Leu Leu Gln Gln Leu Leu Gln Gln Gln Gln Gln Gln Thr Gln Val 
    290                 295                 300                 


Ala Val Ala Gln Val His Leu Leu Lys Asp Gln Leu Ala Ala Glu Ala 
305                 310                 315                 320 


Ala Ala Arg Leu Glu Ala Gln Ala Arg Val His Gln Leu Leu Leu Gln 
                325                 330                 335     


Asn Lys Asp Met Leu Gln His Ile Ser Leu Leu Val Lys Gln Val Gln 
            340                 345                 350         


Glu Leu Glu Leu Lys Leu Ser Gly Gln Asn Ala Met Gly Ser Gln Asp 
        355                 360                 365             


Ser Leu Leu Glu Ile Thr Phe Arg Ser Gly Ala Leu Pro Val Leu Cys 
    370                 375                 380                 


Asp Pro Thr Thr Pro Lys Pro Glu Asp Leu His Ser Pro Pro Leu Gly 
385                 390                 395                 400 


Ala Gly Leu Ala Asp Phe Ala His Pro Ala Gly Ser Pro Leu Gly Arg 
                405                 410                 415     


Arg Asp Cys Leu Val Lys Leu Glu Cys Phe Arg Phe Leu Pro Pro Glu 
            420                 425                 430         


Asp Thr Pro Pro Pro Ala Gln Gly Glu Ala Leu Leu Gly Gly Leu Glu 
        435                 440                 445             


Leu Ile Lys Phe Arg Glu Ser Gly Ile Ala Ser Glu Tyr Glu Ser Asn 
    450                 455                 460                 


Thr Asp Glu Ser Glu Glu Arg Asp Ser Trp Ser Gln Glu Glu Leu Pro 
465                 470                 475                 480 


Arg Leu Leu Asn Val Leu Gln Arg Gln Glu Leu Gly Asp Gly Leu Asp 
                485                 490                 495     


Asp Glu Ile Ala Val 
            500     


<210>  9429
<211>  506
<212>  PRT
<213>  Homo Sapiens

<400>  9429

Met Pro Ser Lys Thr Lys Tyr Asn Leu Val Asp Asp Gly His Asp Leu 
1               5                   10                  15      


Arg Ile Pro Leu His Asn Glu Asp Ala Phe Gln His Gly Ile Cys Phe 
            20                  25                  30          


Glu Ala Lys Tyr Val Gly Ser Leu Asp Val Pro Arg Pro Asn Ser Arg 
        35                  40                  45              


Val Glu Ile Val Ala Ala Met Arg Arg Ile Arg Tyr Glu Phe Lys Ala 
    50                  55                  60                  


Lys Asn Ile Lys Lys Lys Lys Val Ser Ile Met Val Ser Val Asp Gly 
65                  70                  75                  80  


Val Lys Val Ile Leu Lys Lys Lys Lys Lys Leu Leu Leu Leu Gln Lys 
                85                  90                  95      


Lys Glu Trp Thr Trp Asp Glu Ser Lys Met Leu Val Met Gln Asp Pro 
            100                 105                 110         


Ile Tyr Arg Ile Phe Tyr Val Ser His Asp Ser Gln Asp Leu Lys Ile 
        115                 120                 125             


Phe Ser Tyr Ile Ala Arg Asp Gly Ala Ser Asn Ile Phe Arg Cys Asn 
    130                 135                 140                 


Val Phe Lys Ser Lys Lys Lys Ser Gln Ala Met Arg Ile Val Arg Thr 
145                 150                 155                 160 


Val Gly Gln Ala Phe Glu Val Cys His Lys Leu Ser Leu Gln His Thr 
                165                 170                 175     


Gln Gln Asn Ala Asp Gly Gln Glu Asp Gly Glu Ser Glu Arg Asn Ser 
            180                 185                 190         


Asn Ser Ser Gly Asp Pro Gly Arg Gln Leu Thr Gly Ala Glu Arg Ala 
        195                 200                 205             


Ser Thr Ala Thr Ala Glu Glu Thr Asp Ile Asp Ala Val Glu Val Pro 
    210                 215                 220                 


Leu Pro Gly Asn Asp Val Leu Glu Phe Ser Arg Gly Val Thr Asp Leu 
225                 230                 235                 240 


Asp Ala Val Gly Lys Glu Gly Gly Ser His Thr Gly Ser Lys Val Ser 
                245                 250                 255     


His Pro Gln Glu Pro Met Leu Thr Ala Ser Pro Arg Met Leu Leu Pro 
            260                 265                 270         


Ser Ser Ser Ser Lys Pro Pro Gly Leu Gly Thr Glu Thr Pro Leu Ser 
        275                 280                 285             


Thr His His Gln Met Gln Leu Leu Gln Gln Leu Leu Gln Gln Gln Gln 
    290                 295                 300                 


Gln Gln Thr Gln Val Ala Val Ala Gln Val His Leu Leu Lys Asp Gln 
305                 310                 315                 320 


Leu Ala Ala Glu Ala Ala Ala Arg Leu Glu Ala Gln Ala Arg Val His 
                325                 330                 335     


Gln Leu Leu Leu Gln Asn Lys Asp Met Leu Gln His Ile Ser Leu Leu 
            340                 345                 350         


Val Lys Gln Val Gln Glu Leu Glu Leu Lys Leu Ser Gly Gln Asn Ala 
        355                 360                 365             


Met Gly Ser Gln Asp Ser Leu Leu Glu Ile Thr Phe Arg Ser Gly Ala 
    370                 375                 380                 


Leu Pro Val Leu Cys Asp Pro Thr Thr Pro Lys Pro Glu Asp Leu His 
385                 390                 395                 400 


Ser Pro Pro Leu Gly Ala Gly Leu Ala Asp Phe Ala His Pro Ala Gly 
                405                 410                 415     


Ser Pro Leu Gly Arg Arg Asp Cys Leu Val Lys Leu Glu Cys Phe Arg 
            420                 425                 430         


Phe Leu Pro Pro Glu Asp Thr Pro Pro Pro Ala Gln Gly Glu Ala Leu 
        435                 440                 445             


Leu Gly Gly Leu Glu Leu Ile Lys Phe Arg Glu Ser Gly Ile Ala Ser 
    450                 455                 460                 


Glu Tyr Glu Ser Asn Thr Asp Glu Ser Glu Glu Arg Asp Ser Trp Ser 
465                 470                 475                 480 


Gln Glu Glu Leu Pro Arg Leu Leu Asn Val Leu Gln Arg Gln Glu Leu 
                485                 490                 495     


Gly Asp Gly Leu Asp Asp Glu Ile Ala Val 
            500                 505     


<210>  9430
<211>  211
<212>  PRT
<213>  Homo Sapiens

<400>  9430

Met Ser Leu Ser Ser Leu Cys Pro Val Phe Ser Ala Ala Ala Ser Ser 
1               5                   10                  15      


Leu Gln Val His Leu Leu Lys Asp Gln Leu Ala Ala Glu Ala Ala Ala 
            20                  25                  30          


Arg Leu Glu Ala Gln Ala Arg Val His Gln Leu Leu Leu Gln Asn Lys 
        35                  40                  45              


Asp Met Leu Gln His Ile Ser Leu Leu Val Lys Gln Val Gln Glu Leu 
    50                  55                  60                  


Glu Leu Lys Leu Ser Gly Gln Asn Ala Met Gly Ser Gln Asp Ser Leu 
65                  70                  75                  80  


Leu Glu Ile Thr Phe Arg Ser Gly Ala Leu Pro Val Leu Cys Asp Pro 
                85                  90                  95      


Thr Thr Pro Lys Pro Glu Asp Leu His Ser Pro Pro Leu Gly Ala Gly 
            100                 105                 110         


Leu Ala Asp Phe Ala His Pro Ala Gly Ser Pro Leu Gly Arg Arg Asp 
        115                 120                 125             


Cys Leu Val Lys Leu Glu Cys Phe Arg Phe Leu Pro Pro Glu Asp Thr 
    130                 135                 140                 


Pro Pro Pro Ala Gln Gly Glu Ala Leu Leu Gly Gly Leu Glu Leu Ile 
145                 150                 155                 160 


Lys Phe Arg Glu Ser Gly Ile Ala Ser Glu Tyr Glu Ser Asn Thr Asp 
                165                 170                 175     


Glu Ser Glu Glu Arg Asp Ser Trp Ser Gln Glu Glu Leu Pro Arg Leu 
            180                 185                 190         


Leu Asn Val Leu Gln Arg Gln Glu Leu Gly Asp Gly Leu Asp Asp Glu 
        195                 200                 205             


Ile Ala Val 
    210     


<210>  9431
<211>  1286
<212>  PRT
<213>  Homo Sapiens

<400>  9431

Gly Pro Gly Ala Arg Gly Arg Arg Arg Arg Arg Arg Pro Met Ser Pro 
1               5                   10                  15      


Pro Pro Pro Pro Pro Pro Val Arg Ala Leu Pro Leu Leu Leu Leu Leu 
            20                  25                  30          


Ala Gly Pro Gly Ala Ala Ala Pro Pro Cys Leu Asp Gly Ser Pro Cys 
        35                  40                  45              


Ala Asn Gly Gly Arg Cys Thr Gln Leu Pro Ser Arg Glu Ala Ala Cys 
    50                  55                  60                  


Leu Cys Pro Pro Gly Trp Val Gly Glu Arg Cys Gln Leu Glu Asp Pro 
65                  70                  75                  80  


Cys His Ser Gly Pro Cys Ala Gly Arg Gly Val Cys Gln Ser Ser Val 
                85                  90                  95      


Val Ala Gly Thr Ala Arg Phe Ser Cys Arg Cys Pro Arg Gly Phe Arg 
            100                 105                 110         


Gly Pro Asp Cys Ser Leu Pro Asp Pro Cys Leu Ser Ser Pro Cys Ala 
        115                 120                 125             


His Gly Ala Arg Cys Ser Val Gly Pro Asp Gly Arg Phe Leu Cys Ser 
    130                 135                 140                 


Cys Pro Pro Gly Tyr Gln Gly Arg Ser Cys Arg Ser Asp Val Asp Glu 
145                 150                 155                 160 


Cys Arg Val Gly Glu Pro Cys Arg His Gly Gly Thr Cys Leu Asn Thr 
                165                 170                 175     


Pro Gly Ser Phe Arg Cys Gln Cys Pro Ala Gly Tyr Thr Gly Pro Leu 
            180                 185                 190         


Cys Glu Asn Pro Ala Val Pro Cys Ala Pro Ser Pro Cys Arg Asn Gly 
        195                 200                 205             


Gly Thr Cys Arg Gln Ser Gly Asp Leu Thr Tyr Asp Cys Ala Cys Leu 
    210                 215                 220                 


Pro Gly Phe Glu Gly Gln Asn Cys Glu Val Asn Val Asp Asp Cys Pro 
225                 230                 235                 240 


Gly His Arg Cys Leu Asn Gly Gly Thr Cys Val Asp Gly Val Asn Thr 
                245                 250                 255     


Tyr Asn Cys Gln Cys Pro Pro Glu Trp Thr Gly Gln Phe Cys Thr Glu 
            260                 265                 270         


Asp Val Asp Glu Cys Gln Leu Gln Pro Asn Ala Cys His Asn Gly Gly 
        275                 280                 285             


Thr Cys Phe Asn Thr Leu Gly Gly His Ser Cys Val Cys Val Asn Gly 
    290                 295                 300                 


Trp Thr Gly Glu Ser Cys Ser Gln Asn Ile Asp Asp Cys Ala Thr Ala 
305                 310                 315                 320 


Val Cys Phe His Gly Ala Thr Cys His Asp Arg Val Ala Ser Phe Tyr 
                325                 330                 335     


Cys Ala Cys Pro Met Gly Lys Thr Gly Leu Leu Cys His Leu Asp Asp 
            340                 345                 350         


Ala Cys Val Ser Asn Pro Cys His Glu Asp Ala Ile Cys Asp Thr Asn 
        355                 360                 365             


Pro Val Asn Gly Arg Ala Ile Cys Thr Cys Pro Pro Gly Phe Thr Gly 
    370                 375                 380                 


Gly Ala Cys Asp Gln Asp Val Asp Glu Cys Ser Ile Gly Ala Asn Pro 
385                 390                 395                 400 


Cys Glu His Leu Gly Arg Cys Val Asn Thr Gln Gly Ser Phe Leu Cys 
                405                 410                 415     


Gln Cys Gly Arg Gly Tyr Thr Gly Pro Arg Cys Glu Thr Asp Val Asn 
            420                 425                 430         


Glu Cys Leu Ser Gly Pro Cys Arg Asn Gln Ala Thr Cys Leu Asp Arg 
        435                 440                 445             


Ile Gly Gln Phe Thr Cys Ile Cys Met Ala Gly Phe Thr Gly Thr Tyr 
    450                 455                 460                 


Cys Glu Val Asp Ile Asp Glu Cys Gln Ser Ser Pro Cys Val Asn Gly 
465                 470                 475                 480 


Gly Val Cys Lys Asp Arg Val Asn Gly Phe Ser Cys Thr Cys Pro Ser 
                485                 490                 495     


Gly Phe Ser Gly Ser Thr Cys Gln Leu Asp Val Asp Glu Cys Ala Ser 
            500                 505                 510         


Thr Pro Cys Arg Asn Gly Ala Lys Cys Val Asp Gln Pro Asp Gly Tyr 
        515                 520                 525             


Glu Cys Arg Cys Ala Glu Gly Phe Glu Gly Thr Leu Cys Asp Arg Asn 
    530                 535                 540                 


Val Asp Asp Cys Ser Pro Asp Pro Cys His His Gly Arg Cys Val Asp 
545                 550                 555                 560 


Gly Ile Ala Ser Phe Ser Cys Ala Cys Ala Pro Gly Tyr Thr Gly Thr 
                565                 570                 575     


Arg Cys Glu Ser Gln Val Asp Glu Cys Arg Ser Gln Pro Cys Arg His 
            580                 585                 590         


Gly Gly Lys Cys Leu Asp Leu Val Asp Lys Tyr Leu Cys Arg Cys Pro 
        595                 600                 605             


Ser Gly Thr Thr Gly Val Asn Cys Glu Val Asn Ile Asp Asp Cys Ala 
    610                 615                 620                 


Ser Asn Pro Cys Thr Phe Gly Val Cys Arg Asp Gly Ile Asn Arg Tyr 
625                 630                 635                 640 


Asp Cys Val Cys Gln Pro Gly Phe Thr Gly Pro Leu Cys Asn Val Glu 
                645                 650                 655     


Ile Asn Glu Cys Ala Ser Ser Pro Cys Gly Glu Gly Gly Ser Cys Val 
            660                 665                 670         


Asp Gly Glu Asn Gly Phe Arg Cys Leu Cys Pro Pro Gly Ser Leu Pro 
        675                 680                 685             


Pro Leu Cys Leu Pro Pro Ser His Pro Cys Ala His Glu Pro Cys Ser 
    690                 695                 700                 


His Gly Ile Cys Tyr Asp Ala Pro Gly Gly Phe Arg Cys Val Cys Glu 
705                 710                 715                 720 


Pro Gly Trp Ser Gly Pro Arg Cys Ser Gln Ser Leu Ala Arg Asp Ala 
                725                 730                 735     


Cys Glu Ser Gln Pro Cys Arg Ala Gly Gly Thr Cys Ser Ser Asp Gly 
            740                 745                 750         


Met Gly Phe His Cys Thr Cys Pro Pro Gly Val Gln Gly Arg Gln Cys 
        755                 760                 765             


Glu Leu Leu Ser Pro Cys Thr Pro Asn Pro Cys Glu His Gly Gly Arg 
    770                 775                 780                 


Cys Glu Ser Ala Pro Gly Gln Leu Pro Val Cys Ser Cys Pro Gln Gly 
785                 790                 795                 800 


Trp Gln Asp Pro Cys Leu Asn Gly Gly Ser Cys Gln Asp Gly Val Gly 
                805                 810                 815     


Ser Phe Ser Cys Ser Cys Leu Pro Gly Phe Ala Gly Pro Arg Cys Ala 
            820                 825                 830         


Arg Asp Val Asp Glu Cys Leu Ser Asn Pro Cys Gly Pro Gly Thr Cys 
        835                 840                 845             


Thr Asp His Val Ala Ser Phe Thr Cys Thr Cys Pro Pro Gly Tyr Gly 
    850                 855                 860                 


Gly Phe His Cys Glu Gln Asp Leu Pro Asp Cys Ser Pro Ser Ser Cys 
865                 870                 875                 880 


Phe Asn Gly Gly Thr Cys Val Asp Gly Val Asn Ser Phe Ser Cys Leu 
                885                 890                 895     


Cys Arg Pro Gly Tyr Thr Gly Ala His Cys Gln His Glu Ala Asp Pro 
            900                 905                 910         


Cys Leu Ser Arg Pro Cys Leu His Gly Gly Val Cys Ser Ala Ala His 
        915                 920                 925             


Pro Gly Phe Arg Cys Thr Cys Leu Glu Ser Phe Thr Gly Pro Gln Cys 
    930                 935                 940                 


Gln Thr Leu Val Asp Trp Cys Ser Arg Gln Pro Cys Gln Asn Gly Gly 
945                 950                 955                 960 


Arg Cys Val Gln Thr Gly Ala Tyr Cys Leu Cys Pro Pro Gly Trp Ser 
                965                 970                 975     


Gly Arg Leu Cys Asp Ile Arg Ser Leu Pro Cys Arg Glu Ala Ala Ala 
            980                 985                 990         


Gln Ile Gly Val Arg Leu Glu Gln  Leu Cys Gln Ala Gly  Gly Gln Cys 
        995                 1000                 1005             


Val Asp  Glu Asp Ser Ser His  Tyr Cys Val Cys Pro  Glu Gly Arg 
    1010                 1015                 1020             


Thr Gly  Ser His Cys Glu Gln  Glu Val Asp Pro Cys  Leu Ala Gln 
    1025                 1030                 1035             


Pro Cys  Gln His Gly Gly Thr  Cys Arg Gly Tyr Met  Gly Gly Tyr 
    1040                 1045                 1050             


Met Cys  Glu Cys Leu Pro Gly  Tyr Asn Gly Asp Asn  Cys Glu Asp 
    1055                 1060                 1065             


Asp Val  Asp Glu Cys Ala Ser  Gln Pro Cys Gln His  Gly Gly Ser 
    1070                 1075                 1080             


Cys Ile  Asp Leu Val Ala Arg  Tyr Leu Cys Ser Cys  Pro Pro Gly 
    1085                 1090                 1095             


Thr Leu  Gly Val Leu Cys Glu  Ile Asn Glu Asp Asp  Cys Gly Pro 
    1100                 1105                 1110             


Gly Pro  Pro Leu Asp Ser Gly  Pro Arg Cys Leu His  Asn Gly Thr 
    1115                 1120                 1125             


Cys Val  Asp Leu Val Gly Gly  Phe Arg Cys Thr Cys  Pro Pro Gly 
    1130                 1135                 1140             


Tyr Thr  Gly Leu Arg Cys Glu  Ala Asp Ile Asn Glu  Cys Arg Ser 
    1145                 1150                 1155             


Gly Ala  Cys His Ala Ala His  Thr Arg Asp Cys Leu  Gln Asp Pro 
    1160                 1165                 1170             


Gly Gly  Gly Phe Arg Cys Leu  Cys His Ala Gly Phe  Ser Gly Pro 
    1175                 1180                 1185             


Arg Cys  Gln Thr Val Leu Ser  Pro Cys Glu Ser Gln  Pro Cys Gln 
    1190                 1195                 1200             


His Gly  Gly Gln Cys Arg Pro  Ser Pro Gly Pro Gly  Gly Gly Leu 
    1205                 1210                 1215             


Thr Phe  Thr Cys His Cys Ala  Gln Pro Phe Trp Gly  Pro Arg Cys 
    1220                 1225                 1230             


Glu Arg  Val Ala Arg Ser Cys  Arg Glu Leu Gln Cys  Pro Val Gly 
    1235                 1240                 1245             


Val Pro  Cys Gln Gln Thr Pro  Arg Gly Pro Arg Cys  Ala Cys Pro 
    1250                 1255                 1260             


Pro Gly  Leu Ser Gly Pro Ser  Cys Arg Ser Phe Pro  Gly Ser Pro 
    1265                 1270                 1275             


Pro Gly  Ala Ser Asn Ala Ser  Cys 
    1280                 1285     


<210>  9432
<211>  2321
<212>  PRT
<213>  Homo Sapiens

<400>  9432

Met Gly Pro Gly Ala Arg Gly Arg Arg Arg Arg Arg Arg Pro Met Ser 
1               5                   10                  15      


Pro Pro Pro Pro Pro Pro Pro Val Arg Ala Leu Pro Leu Leu Leu Leu 
            20                  25                  30          


Leu Ala Gly Pro Gly Ala Ala Ala Pro Pro Cys Leu Asp Gly Ser Pro 
        35                  40                  45              


Cys Ala Asn Gly Gly Arg Cys Thr Gln Leu Pro Ser Arg Glu Ala Ala 
    50                  55                  60                  


Cys Leu Cys Pro Pro Gly Trp Val Gly Glu Arg Cys Gln Leu Glu Asp 
65                  70                  75                  80  


Pro Cys His Ser Gly Pro Cys Ala Gly Arg Gly Val Cys Gln Ser Ser 
                85                  90                  95      


Val Val Ala Gly Thr Ala Arg Phe Ser Cys Arg Cys Pro Arg Gly Phe 
            100                 105                 110         


Arg Gly Pro Asp Cys Ser Leu Pro Asp Pro Cys Leu Ser Ser Pro Cys 
        115                 120                 125             


Ala His Gly Ala Arg Cys Ser Val Gly Pro Asp Gly Arg Phe Leu Cys 
    130                 135                 140                 


Ser Cys Pro Pro Gly Tyr Gln Gly Arg Ser Cys Arg Ser Asp Val Asp 
145                 150                 155                 160 


Glu Cys Arg Val Gly Glu Pro Cys Arg His Gly Gly Thr Cys Leu Asn 
                165                 170                 175     


Thr Pro Gly Ser Phe Arg Cys Gln Cys Pro Ala Gly Tyr Thr Gly Pro 
            180                 185                 190         


Leu Cys Glu Asn Pro Ala Val Pro Cys Ala Pro Ser Pro Cys Arg Asn 
        195                 200                 205             


Gly Gly Thr Cys Arg Gln Ser Gly Asp Leu Thr Tyr Asp Cys Ala Cys 
    210                 215                 220                 


Leu Pro Gly Phe Glu Gly Gln Asn Cys Glu Val Asn Val Asp Asp Cys 
225                 230                 235                 240 


Pro Gly His Arg Cys Leu Asn Gly Gly Thr Cys Val Asp Gly Val Asn 
                245                 250                 255     


Thr Tyr Asn Cys Gln Cys Pro Pro Glu Trp Thr Gly Gln Phe Cys Thr 
            260                 265                 270         


Glu Asp Val Asp Glu Cys Gln Leu Gln Pro Asn Ala Cys His Asn Gly 
        275                 280                 285             


Gly Thr Cys Phe Asn Thr Leu Gly Gly His Ser Cys Val Cys Val Asn 
    290                 295                 300                 


Gly Trp Thr Gly Glu Ser Cys Ser Gln Asn Ile Asp Asp Cys Ala Thr 
305                 310                 315                 320 


Ala Val Cys Phe His Gly Ala Thr Cys His Asp Arg Val Ala Ser Phe 
                325                 330                 335     


Tyr Cys Ala Cys Pro Met Gly Lys Thr Gly Leu Leu Cys His Leu Asp 
            340                 345                 350         


Asp Ala Cys Val Ser Asn Pro Cys His Glu Asp Ala Ile Cys Asp Thr 
        355                 360                 365             


Asn Pro Val Asn Gly Arg Ala Ile Cys Thr Cys Pro Pro Gly Phe Thr 
    370                 375                 380                 


Gly Gly Ala Cys Asp Gln Asp Val Asp Glu Cys Ser Ile Gly Ala Asn 
385                 390                 395                 400 


Pro Cys Glu His Leu Gly Arg Cys Val Asn Thr Gln Gly Ser Phe Leu 
                405                 410                 415     


Cys Gln Cys Gly Arg Gly Tyr Thr Gly Pro Arg Cys Glu Thr Asp Val 
            420                 425                 430         


Asn Glu Cys Leu Ser Gly Pro Cys Arg Asn Gln Ala Thr Cys Leu Asp 
        435                 440                 445             


Arg Ile Gly Gln Phe Thr Cys Ile Cys Met Ala Gly Phe Thr Gly Thr 
    450                 455                 460                 


Tyr Cys Glu Val Asp Ile Asp Glu Cys Gln Ser Ser Pro Cys Val Asn 
465                 470                 475                 480 


Gly Gly Val Cys Lys Asp Arg Val Asn Gly Phe Ser Cys Thr Cys Pro 
                485                 490                 495     


Ser Gly Phe Ser Gly Ser Thr Cys Gln Leu Asp Val Asp Glu Cys Ala 
            500                 505                 510         


Ser Thr Pro Cys Arg Asn Gly Ala Lys Cys Val Asp Gln Pro Asp Gly 
        515                 520                 525             


Tyr Glu Cys Arg Cys Ala Glu Gly Phe Glu Gly Thr Leu Cys Asp Arg 
    530                 535                 540                 


Asn Val Asp Asp Cys Ser Pro Asp Pro Cys His His Gly Arg Cys Val 
545                 550                 555                 560 


Asp Gly Ile Ala Ser Phe Ser Cys Ala Cys Ala Pro Gly Tyr Thr Gly 
                565                 570                 575     


Thr Arg Cys Glu Ser Gln Val Asp Glu Cys Arg Ser Gln Pro Cys Arg 
            580                 585                 590         


His Gly Gly Lys Cys Leu Asp Leu Val Asp Lys Tyr Leu Cys Arg Cys 
        595                 600                 605             


Pro Ser Gly Thr Thr Gly Val Asn Cys Glu Val Asn Ile Asp Asp Cys 
    610                 615                 620                 


Ala Ser Asn Pro Cys Thr Phe Gly Val Cys Arg Asp Gly Ile Asn Arg 
625                 630                 635                 640 


Tyr Asp Cys Val Cys Gln Pro Gly Phe Thr Gly Pro Leu Cys Asn Val 
                645                 650                 655     


Glu Ile Asn Glu Cys Ala Ser Ser Pro Cys Gly Glu Gly Gly Ser Cys 
            660                 665                 670         


Val Asp Gly Glu Asn Gly Phe Arg Cys Leu Cys Pro Pro Gly Ser Leu 
        675                 680                 685             


Pro Pro Leu Cys Leu Pro Pro Ser His Pro Cys Ala His Glu Pro Cys 
    690                 695                 700                 


Ser His Gly Ile Cys Tyr Asp Ala Pro Gly Gly Phe Arg Cys Val Cys 
705                 710                 715                 720 


Glu Pro Gly Trp Ser Gly Pro Arg Cys Ser Gln Ser Leu Ala Arg Asp 
                725                 730                 735     


Ala Cys Glu Ser Gln Pro Cys Arg Ala Gly Gly Thr Cys Ser Ser Asp 
            740                 745                 750         


Gly Met Gly Phe His Cys Thr Cys Pro Pro Gly Val Gln Gly Arg Gln 
        755                 760                 765             


Cys Glu Leu Leu Ser Pro Cys Thr Pro Asn Pro Cys Glu His Gly Gly 
    770                 775                 780                 


Arg Cys Glu Ser Ala Pro Gly Gln Leu Pro Val Cys Ser Cys Pro Gln 
785                 790                 795                 800 


Gly Trp Gln Gly Pro Arg Cys Gln Gln Asp Val Asp Glu Cys Ala Gly 
                805                 810                 815     


Pro Ala Pro Cys Gly Pro His Gly Ile Cys Thr Asn Leu Ala Gly Ser 
            820                 825                 830         


Phe Ser Cys Thr Cys His Gly Gly Tyr Thr Gly Pro Ser Cys Asp Gln 
        835                 840                 845             


Asp Ile Asn Asp Cys Asp Pro Asn Pro Cys Leu Asn Gly Gly Ser Cys 
    850                 855                 860                 


Gln Asp Gly Val Gly Ser Phe Ser Cys Ser Cys Leu Pro Gly Phe Ala 
865                 870                 875                 880 


Gly Pro Arg Cys Ala Arg Asp Val Asp Glu Cys Leu Ser Asn Pro Cys 
                885                 890                 895     


Gly Pro Gly Thr Cys Thr Asp His Val Ala Ser Phe Thr Cys Thr Cys 
            900                 905                 910         


Pro Pro Gly Tyr Gly Gly Phe His Cys Glu Gln Asp Leu Pro Asp Cys 
        915                 920                 925             


Ser Pro Ser Ser Cys Phe Asn Gly Gly Thr Cys Val Asp Gly Val Asn 
    930                 935                 940                 


Ser Phe Ser Cys Leu Cys Arg Pro Gly Tyr Thr Gly Ala His Cys Gln 
945                 950                 955                 960 


His Glu Ala Asp Pro Cys Leu Ser Arg Pro Cys Leu His Gly Gly Val 
                965                 970                 975     


Cys Ser Ala Ala His Pro Gly Phe Arg Cys Thr Cys Leu Glu Ser Phe 
            980                 985                 990         


Thr Gly Pro Gln Cys Gln Thr Leu  Val Asp Trp Cys Ser  Arg Gln Pro 
        995                 1000                 1005             


Cys Gln  Asn Gly Gly Arg Cys  Val Gln Thr Gly Ala  Tyr Cys Leu 
    1010                 1015                 1020             


Cys Pro  Pro Gly Trp Ser Gly  Arg Leu Cys Asp Ile  Arg Ser Leu 
    1025                 1030                 1035             


Pro Cys  Arg Glu Ala Ala Ala  Gln Ile Gly Val Arg  Leu Glu Gln 
    1040                 1045                 1050             


Leu Cys  Gln Ala Gly Gly Gln  Cys Val Asp Glu Asp  Ser Ser His 
    1055                 1060                 1065             


Tyr Cys  Val Cys Pro Glu Gly  Arg Thr Gly Ser His  Cys Glu Gln 
    1070                 1075                 1080             


Glu Val  Asp Pro Cys Leu Ala  Gln Pro Cys Gln His  Gly Gly Thr 
    1085                 1090                 1095             


Cys Arg  Gly Tyr Met Gly Gly  Tyr Met Cys Glu Cys  Leu Pro Gly 
    1100                 1105                 1110             


Tyr Asn  Gly Asp Asn Cys Glu  Asp Asp Val Asp Glu  Cys Ala Ser 
    1115                 1120                 1125             


Gln Pro  Cys Gln His Gly Gly  Ser Cys Ile Asp Leu  Val Ala Arg 
    1130                 1135                 1140             


Tyr Leu  Cys Ser Cys Pro Pro  Gly Thr Leu Gly Val  Leu Cys Glu 
    1145                 1150                 1155             


Ile Asn  Glu Asp Asp Cys Gly  Pro Gly Pro Pro Leu  Asp Ser Gly 
    1160                 1165                 1170             


Pro Arg  Cys Leu His Asn Gly  Thr Cys Val Asp Leu  Val Gly Gly 
    1175                 1180                 1185             


Phe Arg  Cys Thr Cys Pro Pro  Gly Tyr Thr Gly Leu  Arg Cys Glu 
    1190                 1195                 1200             


Ala Asp  Ile Asn Glu Cys Arg  Ser Gly Ala Cys His  Ala Ala His 
    1205                 1210                 1215             


Thr Arg  Asp Cys Leu Gln Asp  Pro Gly Gly Gly Phe  Arg Cys Leu 
    1220                 1225                 1230             


Cys His  Ala Gly Phe Ser Gly  Pro Arg Cys Gln Thr  Val Leu Ser 
    1235                 1240                 1245             


Pro Cys  Glu Ser Gln Pro Cys  Gln His Gly Gly Gln  Cys Arg Pro 
    1250                 1255                 1260             


Ser Pro  Gly Pro Gly Gly Gly  Leu Thr Phe Thr Cys  His Cys Ala 
    1265                 1270                 1275             


Gln Pro  Phe Trp Gly Pro Arg  Cys Glu Arg Val Ala  Arg Ser Cys 
    1280                 1285                 1290             


Arg Glu  Leu Gln Cys Pro Val  Gly Val Pro Cys Gln  Gln Thr Pro 
    1295                 1300                 1305             


Arg Gly  Pro Arg Cys Ala Cys  Pro Pro Gly Leu Ser  Gly Pro Ser 
    1310                 1315                 1320             


Cys Arg  Ser Phe Pro Gly Ser  Pro Pro Gly Ala Ser  Asn Ala Ser 
    1325                 1330                 1335             


Cys Ala  Ala Ala Pro Cys Leu  His Gly Gly Ser Cys  Arg Pro Ala 
    1340                 1345                 1350             


Pro Leu  Ala Pro Phe Phe Arg  Cys Ala Cys Ala Gln  Gly Trp Thr 
    1355                 1360                 1365             


Gly Pro  Arg Cys Glu Ala Pro  Ala Ala Ala Pro Glu  Val Ser Glu 
    1370                 1375                 1380             


Glu Pro  Arg Cys Pro Arg Ala  Ala Cys Gln Ala Lys  Arg Gly Asp 
    1385                 1390                 1395             


Gln Arg  Cys Asp Arg Glu Cys  Asn Ser Pro Gly Cys  Gly Trp Asp 
    1400                 1405                 1410             


Gly Gly  Asp Cys Ser Leu Ser  Val Gly Asp Pro Trp  Arg Gln Cys 
    1415                 1420                 1425             


Glu Ala  Leu Gln Cys Trp Arg  Leu Phe Asn Asn Ser  Arg Cys Asp 
    1430                 1435                 1440             


Pro Ala  Cys Ser Ser Pro Ala  Cys Leu Tyr Asp Asn  Phe Asp Cys 
    1445                 1450                 1455             


His Ala  Gly Gly Arg Glu Arg  Thr Cys Asn Pro Val  Tyr Glu Lys 
    1460                 1465                 1470             


Tyr Cys  Ala Asp His Phe Ala  Asp Gly Arg Cys Asp  Gln Gly Cys 
    1475                 1480                 1485             


Asn Thr  Glu Glu Cys Gly Trp  Asp Gly Leu Asp Cys  Ala Ser Glu 
    1490                 1495                 1500             


Val Pro  Ala Leu Leu Ala Arg  Gly Val Leu Val Leu  Thr Val Leu 
    1505                 1510                 1515             


Leu Pro  Pro Glu Glu Leu Leu  Arg Ser Ser Ala Asp  Phe Leu Gln 
    1520                 1525                 1530             


Arg Leu  Ser Ala Ile Leu Arg  Thr Ser Leu Arg Phe  Arg Leu Asp 
    1535                 1540                 1545             


Ala His  Gly Gln Ala Met Val  Phe Pro Tyr His Arg  Pro Ser Pro 
    1550                 1555                 1560             


Gly Ser  Glu Pro Arg Ala Arg  Arg Glu Leu Ala Pro  Glu Val Ile 
    1565                 1570                 1575             


Gly Ser  Val Val Met Leu Glu  Ile Asp Asn Arg Leu  Cys Leu Gln 
    1580                 1585                 1590             


Ser Pro  Glu Asn Asp His Cys  Phe Pro Asp Ala Gln  Ser Ala Ala 
    1595                 1600                 1605             


Asp Tyr  Leu Gly Ala Leu Ser  Ala Val Glu Arg Leu  Asp Phe Pro 
    1610                 1615                 1620             


Tyr Pro  Leu Arg Asp Val Arg  Gly Glu Pro Leu Glu  Pro Pro Glu 
    1625                 1630                 1635             


Pro Ser  Val Pro Leu Leu Pro  Leu Leu Val Ala Gly  Ala Val Leu 
    1640                 1645                 1650             


Leu Leu  Val Ile Leu Val Leu  Gly Val Met Val Ala  Arg Arg Lys 
    1655                 1660                 1665             


Arg Glu  His Ser Thr Leu Trp  Phe Pro Glu Gly Phe  Ser Leu His 
    1670                 1675                 1680             


Lys Asp  Val Ala Ser Gly His  Lys Gly Arg Arg Glu  Pro Val Gly 
    1685                 1690                 1695             


Gln Asp  Ala Leu Gly Met Lys  Asn Met Ala Lys Gly  Glu Ser Leu 
    1700                 1705                 1710             


Met Gly  Glu Val Ala Thr Asp  Trp Met Asp Thr Glu  Cys Pro Glu 
    1715                 1720                 1725             


Ala Lys  Arg Leu Lys Val Glu  Glu Pro Gly Met Gly  Ala Glu Glu 
    1730                 1735                 1740             


Ala Val  Asp Cys Arg Gln Trp  Thr Gln His His Leu  Val Ala Ala 
    1745                 1750                 1755             


Asp Ile  Arg Val Ala Pro Ala  Met Ala Leu Thr Pro  Pro Gln Gly 
    1760                 1765                 1770             


Asp Ala  Asp Ala Asp Gly Met  Asp Val Asn Val Arg  Gly Pro Asp 
    1775                 1780                 1785             


Gly Phe  Thr Pro Leu Met Leu  Ala Ser Phe Cys Gly  Gly Ala Leu 
    1790                 1795                 1800             


Glu Pro  Met Pro Thr Glu Glu  Asp Glu Ala Asp Asp  Thr Ser Ala 
    1805                 1810                 1815             


Ser Ile  Ile Ser Asp Leu Ile  Cys Gln Gly Ala Gln  Leu Gly Ala 
    1820                 1825                 1830             


Arg Thr  Asp Arg Thr Gly Glu  Thr Ala Leu His Leu  Ala Ala Arg 
    1835                 1840                 1845             


Tyr Ala  Arg Ala Asp Ala Ala  Lys Arg Leu Leu Asp  Ala Gly Ala 
    1850                 1855                 1860             


Asp Thr  Asn Ala Gln Asp His  Ser Gly Arg Thr Pro  Leu His Thr 
    1865                 1870                 1875             


Ala Val  Thr Ala Asp Ala Gln  Gly Val Phe Gln Ile  Leu Ile Arg 
    1880                 1885                 1890             


Asn Arg  Ser Thr Asp Leu Asp  Ala Arg Met Ala Asp  Gly Ser Thr 
    1895                 1900                 1905             


Ala Leu  Ile Leu Ala Ala Arg  Leu Ala Val Glu Gly  Met Val Glu 
    1910                 1915                 1920             


Glu Leu  Ile Ala Ser His Ala  Asp Val Asn Ala Val  Asp Glu Leu 
    1925                 1930                 1935             


Gly Lys  Ser Ala Leu His Trp  Ala Ala Ala Val Asn  Asn Val Glu 
    1940                 1945                 1950             


Ala Thr  Leu Ala Leu Leu Lys  Asn Gly Ala Asn Lys  Asp Met Gln 
    1955                 1960                 1965             


Asp Ser  Lys Glu Glu Thr Pro  Leu Phe Leu Ala Ala  Arg Glu Gly 
    1970                 1975                 1980             


Ser Tyr  Glu Ala Ala Lys Leu  Leu Leu Asp His Phe  Ala Asn Arg 
    1985                 1990                 1995             


Glu Ile  Thr Asp His Leu Asp  Arg Leu Pro Arg Asp  Val Ala Gln 
    2000                 2005                 2010             


Glu Arg  Leu His Gln Asp Ile  Val Arg Leu Leu Asp  Gln Pro Ser 
    2015                 2020                 2025             


Gly Pro  Arg Ser Pro Pro Gly  Pro His Gly Leu Gly  Pro Leu Leu 
    2030                 2035                 2040             


Cys Pro  Pro Gly Ala Phe Leu  Pro Gly Leu Lys Ala  Ala Gln Ser 
    2045                 2050                 2055             


Gly Ser  Lys Lys Ser Arg Arg  Pro Pro Gly Lys Ala  Gly Leu Gly 
    2060                 2065                 2070             


Pro Gln  Gly Pro Arg Gly Arg  Gly Lys Lys Leu Thr  Leu Ala Cys 
    2075                 2080                 2085             


Pro Gly  Pro Leu Ala Asp Ser  Ser Val Thr Leu Ser  Pro Val Asp 
    2090                 2095                 2100             


Ser Leu  Asp Ser Pro Arg Pro  Phe Gly Gly Pro Pro  Ala Ser Pro 
    2105                 2110                 2115             


Gly Gly  Phe Pro Leu Glu Gly  Pro Tyr Ala Ala Ala  Thr Ala Thr 
    2120                 2125                 2130             


Ala Val  Ser Leu Ala Gln Leu  Gly Gly Pro Gly Arg  Ala Gly Leu 
    2135                 2140                 2145             


Gly Arg  Gln Pro Pro Gly Gly  Cys Val Leu Ser Leu  Gly Leu Leu 
    2150                 2155                 2160             


Asn Pro  Val Ala Val Pro Leu  Asp Trp Ala Arg Leu  Pro Pro Pro 
    2165                 2170                 2175             


Ala Pro  Pro Gly Pro Ser Phe  Leu Leu Pro Leu Ala  Pro Gly Pro 
    2180                 2185                 2190             


Gln Leu  Leu Asn Pro Gly Thr  Pro Val Ser Pro Gln  Glu Arg Pro 
    2195                 2200                 2205             


Pro Pro  Tyr Leu Ala Val Pro  Gly His Gly Glu Glu  Tyr Pro Ala 
    2210                 2215                 2220             


Ala Gly  Ala His Ser Ser Pro  Pro Lys Ala Arg Phe  Leu Arg Val 
    2225                 2230                 2235             


Pro Ser  Glu His Pro Tyr Leu  Thr Pro Ser Pro Glu  Ser Pro Glu 
    2240                 2245                 2250             


His Trp  Ala Ser Pro Ser Pro  Pro Ser Leu Ser Asp  Trp Ser Glu 
    2255                 2260                 2265             


Ser Thr  Pro Ser Pro Ala Thr  Ala Thr Gly Ala Met  Ala Thr Thr 
    2270                 2275                 2280             


Thr Gly  Ala Leu Pro Ala Gln  Pro Leu Pro Leu Ser  Val Pro Ser 
    2285                 2290                 2295             


Ser Leu  Ala Gln Ala Gln Thr  Gln Leu Gly Pro Gln  Pro Glu Val 
    2300                 2305                 2310             


Thr Pro  Lys Arg Gln Val Leu  Ala 
    2315                 2320     


<210>  9433
<211>  117
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9433

Xaa Leu Met Gly Glu Val Ala Thr Asp Trp Met Asp Thr Glu Cys Pro 
1               5                   10                  15      


Glu Ala Lys Arg Leu Lys Val Glu Glu Pro Gly Met Gly Ala Glu Glu 
            20                  25                  30          


Ala Val Asp Cys Arg Gln Trp Thr Gln His His Leu Val Ala Ala Asp 
        35                  40                  45              


Ile Arg Val Ala Pro Ala Met Ala Leu Thr Pro Pro Gln Gly Asp Ala 
    50                  55                  60                  


Asp Ala Asp Gly Met Asp Val Asn Val Arg Gly Pro Asp Ser His Pro 
65                  70                  75                  80  


Lys Pro Leu Tyr Arg Leu Gly Cys Pro His Gly Arg Trp Leu Asn Gly 
                85                  90                  95      


Thr Asp Pro Gly Gly Pro Pro Gly Ser Arg Gly His Gly Gly Arg Ala 
            100                 105                 110         


His Arg Gln Pro Cys 
        115         


<210>  9434
<211>  177
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9434

Xaa Gln Leu Gly Ala Arg Thr Asp Arg Thr Gly Glu Thr Ala Leu His 
1               5                   10                  15      


Leu Ala Ala Arg Tyr Ala Arg Ala Asp Ala Ala Lys Arg Leu Leu Asp 
            20                  25                  30          


Ala Gly Ala Asp Thr Asn Ala Gln Asp His Ser Gly Arg Thr Pro Leu 
        35                  40                  45              


His Thr Ala Val Thr Ala Asp Ala Gln Gly Val Phe Gln Ile Leu Ile 
    50                  55                  60                  


Arg Asn Arg Ser Thr Asp Leu Asp Ala Arg Met Ala Asp Gly Ser Thr 
65                  70                  75                  80  


Ala Leu Ile Leu Ala Ala Arg Leu Ala Val Glu Gly Met Val Glu Glu 
                85                  90                  95      


Leu Ile Ala Ser His Ala Asp Val Asn Ala Val Asp Glu Leu Gly Lys 
            100                 105                 110         


Ser Ala Leu His Trp Ala Ala Ala Val Asn Asn Val Glu Ala Thr Leu 
        115                 120                 125             


Ala Leu Leu Lys Asn Gly Ala Asn Lys Asp Met Gln Asp Ser Lys Val 
    130                 135                 140                 


Ser Pro Ser Pro Trp Ser Thr Gly Cys Gln Gln Trp His Ser Ala Ile 
145                 150                 155                 160 


Ala Ile Gln Pro Gly Gln Gln Ser Glu Thr Leu Ser Lys Asn Lys Thr 
                165                 170                 175     


Lys 
    


<210>  9435
<211>  295
<212>  PRT
<213>  Homo Sapiens

<400>  9435

Met Gly Arg Gly Val Arg Val Leu Leu Leu Leu Ser Leu Leu His Cys 
1               5                   10                  15      


Ala Gly Gly Ser Glu Gly Arg Lys Thr Trp Arg Arg Arg Gly Gln Gln 
            20                  25                  30          


Pro Pro Pro Pro Pro Arg Thr Glu Ala Ala Pro Ala Ala Gly Gln Pro 
        35                  40                  45              


Val Glu Ser Phe Pro Leu Asp Phe Thr Ala Val Glu Gly Asn Met Asp 
    50                  55                  60                  


Ser Phe Met Ala Gln Val Lys Ser Leu Ala Gln Ser Leu Tyr Pro Cys 
65                  70                  75                  80  


Ser Ala Gln Gln Leu Asn Glu Asp Leu Arg Leu His Leu Leu Leu Asn 
                85                  90                  95      


Thr Ser Val Thr Cys Asn Asp Gly Ser Pro Ala Gly Tyr Tyr Leu Lys 
            100                 105                 110         


Glu Ser Arg Gly Ser Arg Arg Trp Leu Leu Phe Leu Glu Gly Gly Trp 
        115                 120                 125             


Tyr Cys Phe Asn Arg Glu Asn Cys Asp Ser Arg Tyr Asp Thr Met Arg 
    130                 135                 140                 


Arg Leu Met Ser Ser Arg Asp Trp Pro Arg Thr Arg Thr Gly Thr Gly 
145                 150                 155                 160 


Ile Leu Ser Ser Gln Pro Glu Glu Asn Pro Tyr Trp Trp Asn Ala Asn 
                165                 170                 175     


Met Val Phe Ile Pro Tyr Cys Ser Ser Asp Val Trp Ser Gly Ala Ser 
            180                 185                 190         


Ser Lys Ser Glu Lys Asn Glu Tyr Ala Phe Met Gly Ala Leu Ile Ile 
        195                 200                 205             


Gln Glu Val Val Arg Glu Leu Leu Gly Arg Gly Leu Ser Gly Ala Lys 
    210                 215                 220                 


Val Leu Leu Leu Ala Gly Ser Ser Ala Gly Gly Thr Gly Val Leu Leu 
225                 230                 235                 240 


Asn Val Asp Arg Val Ala Glu Gln Leu Glu Lys Leu Gly Tyr Pro Ala 
                245                 250                 255     


Ile Gln Val Arg Gly Leu Ala Asp Ser Gly Trp Phe Leu Asp Asn Lys 
            260                 265                 270         


Gln Tyr Arg His Thr Asp Cys Val Asp Thr Ile Thr Cys Ala Pro Thr 
        275                 280                 285             


Glu Ala Ile Arg Arg Gly Ile 
    290                 295 


<210>  9436
<211>  496
<212>  PRT
<213>  Homo Sapiens

<400>  9436

Met Gly Arg Gly Val Arg Val Leu Leu Leu Leu Ser Leu Leu His Cys 
1               5                   10                  15      


Ala Gly Gly Ser Glu Gly Arg Lys Thr Trp Arg Arg Arg Gly Gln Gln 
            20                  25                  30          


Pro Pro Pro Pro Pro Arg Thr Glu Ala Ala Pro Ala Ala Gly Gln Pro 
        35                  40                  45              


Val Glu Ser Phe Pro Leu Asp Phe Thr Ala Val Glu Gly Asn Met Asp 
    50                  55                  60                  


Ser Phe Met Ala Gln Val Lys Ser Leu Ala Gln Ser Leu Tyr Pro Cys 
65                  70                  75                  80  


Ser Ala Gln Gln Leu Asn Glu Asp Leu Arg Leu His Leu Leu Leu Asn 
                85                  90                  95      


Thr Ser Val Thr Cys Asn Asp Gly Ser Pro Ala Gly Tyr Tyr Leu Lys 
            100                 105                 110         


Glu Ser Arg Gly Ser Arg Arg Trp Leu Leu Phe Leu Glu Gly Gly Trp 
        115                 120                 125             


Tyr Cys Phe Asn Arg Glu Asn Cys Asp Ser Arg Tyr Asp Thr Met Arg 
    130                 135                 140                 


Arg Leu Met Ser Ser Arg Asp Trp Pro Arg Thr Arg Thr Gly Thr Gly 
145                 150                 155                 160 


Ile Leu Ser Ser Gln Pro Glu Glu Asn Pro Tyr Trp Trp Asn Ala Asn 
                165                 170                 175     


Met Val Phe Ile Pro Tyr Cys Ser Ser Asp Val Trp Ser Gly Ala Ser 
            180                 185                 190         


Ser Lys Ser Glu Lys Asn Glu Tyr Ala Phe Met Gly Ala Leu Ile Ile 
        195                 200                 205             


Gln Glu Val Val Arg Glu Leu Leu Gly Arg Gly Leu Ser Gly Ala Lys 
    210                 215                 220                 


Val Leu Leu Leu Ala Gly Ser Ser Ala Gly Gly Thr Gly Val Leu Leu 
225                 230                 235                 240 


Asn Val Asp Arg Val Ala Glu Gln Leu Glu Lys Leu Gly Tyr Pro Ala 
                245                 250                 255     


Ile Gln Val Arg Gly Leu Ala Asp Ser Gly Trp Phe Leu Asp Asn Lys 
            260                 265                 270         


Gln Tyr Arg His Thr Asp Cys Val Asp Thr Ile Thr Cys Ala Pro Thr 
        275                 280                 285             


Glu Ala Ile Arg Arg Gly Ile Arg Tyr Trp Asn Gly Val Val Pro Glu 
    290                 295                 300                 


Arg Cys Arg Arg Gln Phe Gln Glu Gly Glu Glu Trp Asn Cys Phe Phe 
305                 310                 315                 320 


Gly Tyr Lys Val Tyr Pro Thr Leu Arg Cys Pro Val Phe Val Val Gln 
                325                 330                 335     


Trp Leu Phe Asp Glu Ala Gln Leu Thr Val Asp Asn Val His Leu Thr 
            340                 345                 350         


Gly Gln Pro Val Gln Glu Gly Leu Arg Leu Tyr Ile Gln Asn Leu Gly 
        355                 360                 365             


Arg Glu Leu Arg His Thr Leu Lys Asp Val Pro Ala Ser Phe Ala Pro 
    370                 375                 380                 


Ala Cys Leu Ser His Glu Ile Ile Ile Arg Ser His Trp Thr Asp Val 
385                 390                 395                 400 


Gln Val Lys Gly Thr Ser Leu Pro Arg Ala Leu His Cys Trp Asp Arg 
                405                 410                 415     


Ser Leu His Asp Ser His Lys Ala Ser Lys Thr Pro Leu Lys Gly Cys 
            420                 425                 430         


Pro Val His Leu Val Asp Ser Cys Pro Trp Pro His Cys Asn Pro Ser 
        435                 440                 445             


Cys Pro Thr Val Arg Asp Gln Phe Thr Gly Gln Glu Met Asn Val Ala 
    450                 455                 460                 


Gln Phe Leu Met His Met Gly Phe Asp Met Gln Thr Val Ala Gln Pro 
465                 470                 475                 480 


Gln Gly Leu Glu Pro Ser Glu Leu Leu Gly Met Leu Ser Asn Gly Ser 
                485                 490                 495     


<210>  9437
<211>  197
<212>  PRT
<213>  Homo Sapiens

<400>  9437

Met Arg Arg Leu Met Ser Ser Arg Asp Trp Pro Arg Thr Arg Thr Gly 
1               5                   10                  15      


Thr Gly Ile Leu Ser Ser Gln Pro Glu Glu Asn Pro Tyr Trp Trp Asn 
            20                  25                  30          


Ala Asn Met Val Phe Ile Pro Tyr Cys Ser Ser Asp Val Trp Ser Gly 
        35                  40                  45              


Ala Ser Ser Lys Ser Glu Lys Asn Glu Tyr Ala Phe Met Gly Ala Leu 
    50                  55                  60                  


Ile Ile Gln Glu Val Val Arg Glu Leu Leu Gly Arg Gly Leu Ser Gly 
65                  70                  75                  80  


Ala Lys Val Leu Leu Leu Ala Gly Ser Ser Ala Gly Gly Thr Gly Val 
                85                  90                  95      


Leu Leu Asn Val Asp Arg Val Ala Glu Gln Leu Glu Lys Leu Gly Tyr 
            100                 105                 110         


Pro Ala Ile Gln Val Arg Gly Leu Ala Asp Ser Gly Trp Phe Leu Asp 
        115                 120                 125             


Asn Lys Gln Tyr Arg His Thr Asp Cys Val Asp Thr Ile Thr Cys Ala 
    130                 135                 140                 


Pro Thr Glu Ala Ile Arg Arg Gly Ile Arg Tyr Trp Asn Gly Val Val 
145                 150                 155                 160 


Pro Glu Arg Cys Arg Arg Gln Phe Gln Glu Gly Glu Glu Trp Asn Cys 
                165                 170                 175     


Phe Phe Gly Tyr Lys Val Tyr Pro Thr Leu Arg Cys Pro Val Phe Val 
            180                 185                 190         


Val Gln Trp Leu Phe 
        195         


<210>  9438
<211>  357
<212>  PRT
<213>  Homo Sapiens

<400>  9438

Met Gln Ser Val Gln Ser Thr Ser Phe Cys Leu Arg Lys Gln Cys Leu 
1               5                   10                  15      


Cys Leu Thr Phe Leu Leu Leu His Leu Leu Gly Gln Val Ala Ala Thr 
            20                  25                  30          


Gln Arg Cys Pro Pro Gln Cys Pro Gly Arg Cys Pro Ala Thr Pro Pro 
        35                  40                  45              


Thr Cys Ala Pro Gly Val Arg Ala Val Leu Asp Gly Cys Ser Cys Cys 
    50                  55                  60                  


Leu Val Cys Ala Arg Gln Arg Gly Glu Ser Cys Ser Asp Leu Glu Pro 
65                  70                  75                  80  


Cys Asp Glu Ser Ser Gly Leu Tyr Cys Asp Arg Ser Ala Asp Pro Ser 
                85                  90                  95      


Asn Gln Thr Gly Ile Cys Thr Ala Val Glu Gly Asp Asn Cys Val Phe 
            100                 105                 110         


Asp Gly Val Ile Tyr Arg Ser Gly Glu Lys Phe Gln Pro Ser Cys Lys 
        115                 120                 125             


Phe Gln Cys Thr Cys Arg Asp Gly Gln Ile Gly Cys Val Pro Arg Cys 
    130                 135                 140                 


Gln Leu Asp Val Leu Leu Pro Glu Pro Asn Cys Pro Ala Pro Arg Lys 
145                 150                 155                 160 


Val Glu Val Pro Gly Glu Cys Cys Glu Lys Trp Ile Cys Gly Pro Asp 
                165                 170                 175     


Glu Glu Asp Ser Leu Gly Gly Leu Thr Leu Ala Ala Tyr Arg Pro Glu 
            180                 185                 190         


Ala Thr Leu Gly Val Glu Val Ser Asp Ser Ser Val Asn Cys Ile Glu 
        195                 200                 205             


Gln Thr Thr Glu Trp Thr Ala Cys Ser Lys Ser Cys Gly Met Gly Phe 
    210                 215                 220                 


Ser Thr Arg Val Thr Asn Arg Asn Arg Gln Cys Glu Met Leu Lys Gln 
225                 230                 235                 240 


Thr Arg Leu Cys Met Val Arg Pro Cys Glu Gln Glu Pro Glu Gln Pro 
                245                 250                 255     


Thr Asp Lys Lys Gly Lys Lys Cys Leu Arg Thr Lys Lys Ser Leu Lys 
            260                 265                 270         


Ala Ile His Leu Gln Phe Lys Asn Cys Thr Ser Leu His Thr Tyr Lys 
        275                 280                 285             


Pro Arg Phe Cys Gly Val Cys Ser Asp Gly Arg Cys Cys Thr Pro His 
    290                 295                 300                 


Asn Thr Lys Thr Ile Gln Ala Glu Phe Gln Cys Ser Pro Gly Gln Ile 
305                 310                 315                 320 


Val Lys Lys Pro Val Met Val Ile Gly Thr Cys Thr Cys His Thr Asn 
                325                 330                 335     


Cys Pro Lys Asn Asn Glu Ala Phe Leu Gln Glu Leu Glu Leu Lys Thr 
            340                 345                 350         


Thr Arg Gly Lys Met 
        355         


<210>  9439
<211>  125
<212>  PRT
<213>  Homo Sapiens

<400>  9439

Met Ala Arg Ser Ala Thr Leu Ala Ala Ala Ala Leu Ala Leu Cys Leu 
1               5                   10                  15      


Leu Leu Ala Pro Pro Gly Leu Ala Trp Tyr Lys Pro Ala Ala Gly His 
            20                  25                  30          


Ser Ser Tyr Ser Val Gly Arg Ala Ala Gly Leu Leu Ser Gly Leu Arg 
        35                  40                  45              


Arg Ser Pro Tyr Ala Arg Arg Ser Gln Pro Tyr Arg Gly Ala Glu Pro 
    50                  55                  60                  


Pro Gly Gly Ala Gly Ala Ser Pro Glu Leu Gln Leu His Pro Arg Leu 
65                  70                  75                  80  


Arg Ser Leu Ala Val Cys Val Gln Asp Val Ala Pro Asn Leu Gln Arg 
                85                  90                  95      


Cys Glu Arg Leu Pro Asp Gly Arg Gly Thr Tyr Gln Cys Lys Ala Asn 
            100                 105                 110         


Val Phe Leu Ser Leu Arg Ala Ala Asp Cys Leu Ala Ala 
        115                 120                 125 


<210>  9440
<211>  156
<212>  PRT
<213>  Homo Sapiens

<400>  9440

Met Ala Arg Ser Ala Thr Leu Ala Ala Ala Ala Leu Ala Leu Cys Leu 
1               5                   10                  15      


Leu Leu Ala Pro Pro Gly Leu Ala Trp Tyr Lys Pro Ala Ala Gly His 
            20                  25                  30          


Ser Ser Tyr Ser Val Gly Arg Ala Ala Gly Leu Leu Ser Gly Leu Arg 
        35                  40                  45              


Arg Ser Pro Tyr Ala Arg Arg Ser Gln Pro Tyr Arg Gly Ala Glu Pro 
    50                  55                  60                  


Pro Gly Gly Ala Gly Ala Ser Pro Glu Leu Gln Leu His Pro Arg Leu 
65                  70                  75                  80  


Arg Ser Leu Val Ser Pro Ala Cys Arg Gly Leu Met Gly Gly Gly Gly 
                85                  90                  95      


Arg Thr Trp Val Gly Val Arg Arg Pro Leu Ser Leu Cys Leu Pro Ala 
            100                 105                 110         


Pro Gln Ala Val Cys Val Gln Asp Val Ala Pro Asn Leu Gln Arg Cys 
        115                 120                 125             


Glu Arg Leu Pro Asp Gly Arg Gly Thr Tyr Gln Cys Lys Ala Asn Val 
    130                 135                 140                 


Phe Leu Ser Leu Arg Ala Ala Asp Cys Leu Ala Ala 
145                 150                 155     


<210>  9441
<211>  53
<212>  PRT
<213>  Homo Sapiens

<400>  9441

Gly Ala Gln His Arg Cys Pro Gly Arg Thr Gly Ala Val Gln Gly Leu 
1               5                   10                  15      


Arg Phe Cys Gly Trp Ser Tyr Lys Gly Ser Glu Cys Glu Pro Met Pro 
            20                  25                  30          


His Pro Thr Leu Pro Ala Glu Gln Arg Thr Val Leu Gln Arg Gln Cys 
        35                  40                  45              


His Leu His Gln Gln 
    50              


<210>  9442
<211>  201
<212>  PRT
<213>  Homo Sapiens

<400>  9442

Met Arg Phe Leu Ala Ala Thr Phe Leu Leu Leu Ala Leu Ser Thr Ala 
1               5                   10                  15      


Ala Gln Ala Glu Pro Val Gln Phe Lys Asp Cys Gly Ser Val Asp Gly 
            20                  25                  30          


Val Ile Lys Glu Val Asn Val Ser Pro Cys Pro Thr Gln Pro Cys Gln 
        35                  40                  45              


Leu Ser Lys Gly Gln Ser Tyr Ser Val Asn Val Thr Phe Thr Ser Asn 
    50                  55                  60                  


Ile Gln Ser Lys Ser Ser Lys Ala Val Val His Gly Ile Leu Met Gly 
65                  70                  75                  80  


Val Pro Val Pro Phe Pro Ile Pro Glu Pro Asp Gly Cys Lys Ser Gly 
                85                  90                  95      


Ile Asn Cys Pro Ile Gln Lys Asp Lys Thr Tyr Ser Tyr Leu Asn Lys 
            100                 105                 110         


Leu Pro Val Lys Ser Glu Tyr Pro Ser Ile Lys Leu Val Val Glu Trp 
        115                 120                 125             


Gln Leu Gln Asp Asp Lys Asn Gln Ser Leu Phe Cys Trp Glu Ile Pro 
    130                 135                 140                 


Val Gln Ile Met Phe Pro Cys Leu Phe Ser Ala His Cys Pro Met Leu 
145                 150                 155                 160 


Ala Thr Glu His Arg Cys Leu Gln Leu Gln Met Glu Thr Lys Ser Leu 
                165                 170                 175     


Arg Phe Trp Ser Arg Arg Gly Met Ser Val Trp Leu Pro Ser Pro Ala 
            180                 185                 190         


Gly Ala Trp Arg Arg Thr Ala Pro Phe 
        195                 200     


<210>  9443
<211>  151
<212>  PRT
<213>  Homo Sapiens

<400>  9443

Met Arg Phe Leu Ala Ala Thr Phe Leu Leu Leu Ala Leu Ser Thr Ala 
1               5                   10                  15      


Ala Gln Ala Glu Pro Val Gln Phe Lys Asp Cys Gly Ser Val Asp Gly 
            20                  25                  30          


Val Ile Lys Glu Val Asn Val Ser Pro Cys Pro Thr Gln Pro Cys Gln 
        35                  40                  45              


Leu Ser Lys Gly Gln Ser Tyr Ser Val Asn Val Thr Phe Thr Ser Asn 
    50                  55                  60                  


Ile Gln Ser Lys Ser Ser Lys Ala Val Val His Gly Ile Leu Met Gly 
65                  70                  75                  80  


Val Pro Val Pro Phe Pro Ile Pro Glu Pro Asp Gly Cys Lys Ser Gly 
                85                  90                  95      


Ile Asn Cys Pro Ile Gln Lys Asp Lys Thr Tyr Ser Tyr Leu Asn Lys 
            100                 105                 110         


Leu Pro Val Lys Ser Glu Tyr Pro Ser Ile Lys Leu Val Val Glu Trp 
        115                 120                 125             


Gln Leu Gln Asp Asp Lys Asn Gln Ser Leu Phe Cys Trp Glu Ile Pro 
    130                 135                 140                 


Val Gln Ile Val Ser His Leu 
145                 150     


<210>  9444
<211>  174
<212>  PRT
<213>  Homo Sapiens

<400>  9444

Met Arg Phe Leu Ala Ala Thr Phe Leu Leu Leu Ala Leu Ser Thr Ala 
1               5                   10                  15      


Ala Gln Ala Glu Pro Val Gln Phe Lys Asp Cys Gly Ser Val Asp Gly 
            20                  25                  30          


Val Ile Lys Glu Val Asn Val Ser Pro Cys Pro Thr Gln Pro Cys Gln 
        35                  40                  45              


Leu Ser Lys Gly Gln Ser Tyr Ser Val Asn Val Thr Phe Thr Ser Asn 
    50                  55                  60                  


Ile Gln Ser Lys Ser Ser Lys Ala Val Val His Gly Ile Leu Met Gly 
65                  70                  75                  80  


Val Pro Val Pro Phe Pro Ile Pro Glu Pro Asp Gly Cys Lys Ser Gly 
                85                  90                  95      


Ile Asn Cys Pro Ile Gln Lys Asp Lys Thr Tyr Ser Tyr Leu Asn Lys 
            100                 105                 110         


Leu Pro Val Lys Ser Glu Tyr Pro Ser Ile Lys Leu Val Val Glu Trp 
        115                 120                 125             


Gln Leu Gln Asp Asp Lys Asn Gln Ser Leu Phe Cys Trp Glu Ile Pro 
    130                 135                 140                 


Val Gln Ile Val Ser Leu Ser Gly Gly Glu Arg Ala Trp Val Glu Gly 
145                 150                 155                 160 


Arg Lys Trp Arg Arg Asn Gln Thr Glu Thr Lys Ser Val Pro 
                165                 170                 


<210>  9445
<211>  221
<212>  PRT
<213>  Homo Sapiens

<400>  9445

Met Arg Phe Leu Ala Ala Thr Phe Leu Leu Leu Ala Leu Ser Thr Ala 
1               5                   10                  15      


Ala Gln Ala Glu Pro Val Gln Phe Lys Asp Cys Gly Ser Val Asp Gly 
            20                  25                  30          


Val Ile Lys Glu Val Asn Val Ser Pro Cys Pro Thr Gln Pro Cys Gln 
        35                  40                  45              


Leu Ser Lys Gly Gln Ser Tyr Ser Val Asn Val Thr Phe Thr Ser Asn 
    50                  55                  60                  


Ile Gln Ser Lys Ser Ser Lys Ala Val Val His Gly Ile Leu Met Gly 
65                  70                  75                  80  


Val Pro Val Pro Phe Pro Ile Pro Glu Pro Asp Gly Cys Lys Ser Gly 
                85                  90                  95      


Ile Asn Cys Pro Ile Gln Lys Asp Lys Thr Tyr Ser Tyr Leu Asn Lys 
            100                 105                 110         


Leu Pro Val Lys Ser Glu Tyr Pro Ser Ile Lys Leu Val Val Glu Trp 
        115                 120                 125             


Gln Leu Gln Asp Asp Lys Asn Gln Ser Leu Phe Cys Trp Glu Ile Pro 
    130                 135                 140                 


Val Gln Ile Val Ser Leu Ser Gly Gly Phe Ser Ser Leu Ser Ala Ser 
145                 150                 155                 160 


Leu Ser Ser Val His Leu Ala Asn Glu Ser Ala Glu Thr Leu Asp Ser 
                165                 170                 175     


Thr Ser Ser Ser Ala Ala Ser Thr Thr Val Thr Cys Ser Pro Met Val 
            180                 185                 190         


Ser Ser Asp Ser Leu Lys Arg Arg Cys Ser Val Ala Glu Thr Glu Leu 
        195                 200                 205             


Arg Val Ala Gly Ser Gln Trp Leu Ser His Val Ser Phe 
    210                 215                 220     


<210>  9446
<211>  148
<212>  PRT
<213>  Homo Sapiens

<400>  9446

Met Arg Phe Leu Ala Ala Thr Phe Leu Leu Leu Ala Leu Ser Thr Ala 
1               5                   10                  15      


Ala Gln Ala Glu Pro Val Gln Phe Lys Asp Cys Gly Ser Val Asp Gly 
            20                  25                  30          


Val Ile Lys Glu Val Asn Val Ser Pro Cys Pro Thr Gln Pro Cys Gln 
        35                  40                  45              


Leu Ser Lys Gly Gln Ser Tyr Ser Val Asn Val Thr Phe Thr Ser Asn 
    50                  55                  60                  


Ile Gln Ser Lys Ser Ser Lys Ala Val Val His Gly Ile Leu Met Gly 
65                  70                  75                  80  


Val Pro Val Pro Phe Pro Ile Pro Glu Pro Asp Gly Cys Lys Ser Gly 
                85                  90                  95      


Ile Asn Cys Pro Ile Gln Lys Asp Lys Thr Tyr Ser Tyr Leu Asn Lys 
            100                 105                 110         


Leu Pro Val Lys Ser Glu Tyr Pro Ser Ile Lys Leu Val Val Glu Trp 
        115                 120                 125             


Gln Leu Gln Asp Asp Lys Asn Gln Ser Leu Phe Cys Trp Glu Ile Pro 
    130                 135                 140                 


Val Ser His Leu 
145             


<210>  9447
<211>  122
<212>  PRT
<213>  Homo Sapiens

<400>  9447

Met Arg Phe Leu Ala Ala Thr Phe Leu Leu Leu Ala Leu Ser Thr Ala 
1               5                   10                  15      


Ala Gln Ala Glu Pro Val Gln Phe Lys Asp Cys Gly Ser Val Asp Gly 
            20                  25                  30          


Val Ile Lys Glu Val Asn Val Ser Pro Cys Pro Thr Gln Pro Cys Gln 
        35                  40                  45              


Leu Ser Lys Gly Gln Ser Tyr Ser Val Asn Val Thr Phe Thr Ser Asn 
    50                  55                  60                  


Ile Gln Ser Lys Ser Ser Lys Ala Val Val His Gly Ile Leu Met Gly 
65                  70                  75                  80  


Val Pro Val Pro Phe Pro Ile Pro Glu Pro Asp Gly Cys Lys Ser Gly 
                85                  90                  95      


Ile Asn Cys Pro Ile Gln Lys Asp Lys Thr Tyr Ser Tyr Leu Asn Lys 
            100                 105                 110         


Leu Pro Val Lys Ser Glu Tyr Pro Ser Val 
        115                 120         


<210>  9448
<211>  125
<212>  PRT
<213>  Homo Sapiens

<400>  9448

Met Arg Phe Leu Ala Ala Thr Phe Leu Leu Leu Ala Leu Ser Thr Ala 
1               5                   10                  15      


Ala Gln Ala Glu Pro Val Gln Phe Lys Asp Cys Gly Ser Val Asp Gly 
            20                  25                  30          


Val Ile Lys Glu Val Asn Val Ser Pro Cys Pro Thr Gln Pro Cys Gln 
        35                  40                  45              


Leu Ser Lys Gly Gln Ser Tyr Ser Val Asn Val Thr Phe Thr Ser Asn 
    50                  55                  60                  


Ile Gln Ser Lys Ser Ser Lys Ala Val Val His Gly Ile Leu Met Gly 
65                  70                  75                  80  


Val Pro Val Pro Phe Pro Ile Pro Glu Pro Asp Gly Cys Lys Ser Gly 
                85                  90                  95      


Ile Asn Cys Pro Ile Gln Lys Asp Lys Thr Tyr Ser Tyr Leu Asn Lys 
            100                 105                 110         


Leu Pro Val Lys Ser Glu Tyr Pro Ser Val Ser His Leu 
        115                 120                 125 


<210>  9449
<211>  173
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9449

Xaa Pro Leu Arg Val Arg Pro Pro Thr Trp Thr Gln Leu Ser Val Arg 
1               5                   10                  15      


Arg Ile Cys Pro Ser Pro Ala Ser Gly Leu Glu Asp Asp Ala Ser Arg 
            20                  25                  30          


Arg Ala Trp Gly Pro Arg Glu Ala Val Arg Ser Leu Arg Ala Arg Glu 
        35                  40                  45              


Glu Gly Ser Val Asp Gly Val Ile Lys Glu Val Asn Val Ser Pro Cys 
    50                  55                  60                  


Pro Thr Gln Pro Cys Gln Leu Ser Lys Gly Gln Ser Tyr Ser Val Asn 
65                  70                  75                  80  


Val Thr Phe Thr Ser Asn Ile Gln Ser Lys Ser Ser Lys Ala Val Val 
                85                  90                  95      


His Gly Ile Leu Met Gly Val Pro Val Pro Phe Pro Ile Pro Glu Pro 
            100                 105                 110         


Asp Gly Cys Lys Ser Gly Ile Asn Cys Pro Ile Gln Lys Asp Lys Thr 
        115                 120                 125             


Tyr Ser Tyr Leu Asn Lys Leu Pro Val Lys Ser Glu Tyr Pro Ser Ile 
    130                 135                 140                 


Lys Leu Val Val Glu Trp Gln Leu Gln Asp Asp Lys Asn Gln Ser Leu 
145                 150                 155                 160 


Phe Cys Trp Glu Ile Pro Val Gln Ile Val Ser His Leu 
                165                 170             


<210>  9450
<211>  113
<212>  PRT
<213>  Homo Sapiens

<400>  9450

Met Asp Ser Arg Gln Ala Ala Ala Leu Leu Val Leu Leu Leu Leu Ile 
1               5                   10                  15      


Asp Gly Gly Cys Ala Glu Gly Pro Gly Gly Gln Gln Glu Asp Gln Leu 
            20                  25                  30          


Ser Ala Glu Glu Asp Ser Glu Pro Leu Pro Pro Gln Asp Ala Gln Thr 
        35                  40                  45              


Ser Gly Ser Leu Leu His Tyr Leu Leu Gln Ala Met Glu Arg Pro Gly 
    50                  55                  60                  


Arg Ser Gln Ala Phe Leu Phe Gln Pro Gln Arg Phe Gly Arg Asn Thr 
65                  70                  75                  80  


Gln Gly Ser Trp Arg Asn Glu Trp Leu Ser Pro Arg Ala Gly Glu Gly 
                85                  90                  95      


Leu Asn Ser Gln Phe Trp Ser Leu Ala Ala Pro Gln Arg Phe Gly Lys 
            100                 105                 110         


Lys 
    


<210>  9451
<211>  423
<212>  PRT
<213>  Homo Sapiens

<400>  9451

Met Phe Ile Met Asn Glu Lys Trp Asp Thr Asn Ser Ser Glu Asn Trp 
1               5                   10                  15      


His Pro Ile Trp Asn Val Asn Asp Thr Lys His His Leu Tyr Ser Asp 
            20                  25                  30          


Ile Asn Ile Thr Tyr Val Asn Tyr Tyr Leu His Gln Pro Gln Val Ala 
        35                  40                  45              


Ala Ile Phe Ile Ile Ser Tyr Phe Leu Ile Phe Phe Leu Cys Met Met 
    50                  55                  60                  


Gly Asn Thr Val Val Cys Phe Ile Val Met Arg Asn Lys His Met His 
65                  70                  75                  80  


Thr Val Thr Asn Leu Phe Ile Leu Asn Leu Ala Ile Ser Asp Leu Leu 
                85                  90                  95      


Val Gly Ile Phe Cys Met Pro Ile Thr Leu Leu Asp Asn Ile Ile Ala 
            100                 105                 110         


Gly Trp Pro Phe Gly Asn Thr Met Cys Lys Ile Ser Gly Leu Val Gln 
        115                 120                 125             


Gly Ile Ser Val Ala Ala Ser Val Phe Thr Leu Val Ala Ile Ala Val 
    130                 135                 140                 


Asp Arg Phe Gln Cys Val Val Tyr Pro Phe Lys Pro Lys Leu Thr Ile 
145                 150                 155                 160 


Lys Thr Ala Phe Val Ile Ile Met Ile Ile Trp Val Leu Ala Ile Thr 
                165                 170                 175     


Ile Met Ser Pro Ser Ala Val Met Leu His Val Gln Glu Glu Lys Tyr 
            180                 185                 190         


Tyr Arg Val Arg Leu Asn Ser Gln Asn Lys Thr Ser Pro Val Tyr Trp 
        195                 200                 205             


Cys Arg Glu Asp Trp Pro Asn Gln Glu Met Arg Lys Ile Tyr Thr Thr 
    210                 215                 220                 


Val Leu Phe Ala Asn Ile Tyr Leu Ala Pro Leu Ser Leu Ile Val Ile 
225                 230                 235                 240 


Met Tyr Gly Arg Ile Gly Ile Ser Leu Phe Arg Ala Ala Val Pro His 
                245                 250                 255     


Thr Gly Arg Lys Asn Gln Glu Gln Trp His Val Val Ser Arg Lys Lys 
            260                 265                 270         


Gln Lys Ile Ile Lys Met Leu Leu Ile Val Ala Leu Leu Phe Ile Leu 
        275                 280                 285             


Ser Trp Leu Pro Leu Trp Thr Leu Met Met Leu Ser Asp Tyr Ala Asp 
    290                 295                 300                 


Leu Ser Pro Asn Glu Leu Gln Ile Ile Asn Ile Tyr Ile Tyr Pro Phe 
305                 310                 315                 320 


Ala His Trp Leu Ala Phe Gly Asn Ser Ser Val Asn Pro Ile Ile Tyr 
                325                 330                 335     


Gly Phe Phe Asn Glu Asn Phe Arg Arg Gly Phe Gln Glu Ala Phe Gln 
            340                 345                 350         


Leu Gln Leu Cys Gln Lys Arg Ala Lys Pro Met Glu Ala Tyr Ala Leu 
        355                 360                 365             


Lys Ala Lys Ser His Val Leu Ile Asn Thr Ser Asn Gln Leu Val Gln 
    370                 375                 380                 


Glu Ser Thr Phe Gln Asn Pro His Gly Glu Thr Leu Leu Tyr Arg Lys 
385                 390                 395                 400 


Ser Ala Glu Lys Pro Gln Gln Glu Leu Val Met Glu Glu Leu Lys Glu 
                405                 410                 415     


Thr Thr Asn Ser Ser Glu Ile 
            420             


<210>  9452
<211>  420
<212>  PRT
<213>  Homo Sapiens

<400>  9452

Met Asn Glu Lys Trp Asp Thr Asn Ser Ser Glu Asn Trp His Pro Ile 
1               5                   10                  15      


Trp Asn Val Asn Asp Thr Lys His His Leu Tyr Ser Asp Ile Asn Ile 
            20                  25                  30          


Thr Tyr Val Asn Tyr Tyr Leu His Gln Pro Gln Val Ala Ala Ile Phe 
        35                  40                  45              


Ile Ile Ser Tyr Phe Leu Ile Phe Phe Leu Cys Met Met Gly Asn Thr 
    50                  55                  60                  


Val Val Cys Phe Ile Val Met Arg Asn Lys His Met His Thr Val Thr 
65                  70                  75                  80  


Asn Leu Phe Ile Leu Asn Leu Ala Ile Ser Asp Leu Leu Val Gly Ile 
                85                  90                  95      


Phe Cys Met Pro Ile Thr Leu Leu Asp Asn Ile Ile Ala Gly Trp Pro 
            100                 105                 110         


Phe Gly Asn Thr Met Cys Lys Ile Ser Gly Leu Val Gln Gly Ile Ser 
        115                 120                 125             


Val Ala Ala Ser Val Phe Thr Leu Val Ala Ile Ala Val Asp Arg Phe 
    130                 135                 140                 


Gln Cys Val Val Tyr Pro Phe Lys Pro Lys Leu Thr Ile Lys Thr Ala 
145                 150                 155                 160 


Phe Val Ile Ile Met Ile Ile Trp Val Leu Ala Ile Thr Ile Met Ser 
                165                 170                 175     


Pro Ser Ala Val Met Leu His Val Gln Glu Glu Lys Tyr Tyr Arg Val 
            180                 185                 190         


Arg Leu Asn Ser Gln Asn Lys Thr Ser Pro Val Tyr Trp Cys Arg Glu 
        195                 200                 205             


Asp Trp Pro Asn Gln Glu Met Arg Lys Ile Tyr Thr Thr Val Leu Phe 
    210                 215                 220                 


Ala Asn Ile Tyr Leu Ala Pro Leu Ser Leu Ile Val Ile Met Tyr Gly 
225                 230                 235                 240 


Arg Ile Gly Ile Ser Leu Phe Arg Ala Ala Val Pro His Thr Gly Arg 
                245                 250                 255     


Lys Asn Gln Glu Gln Trp His Val Val Ser Arg Lys Lys Gln Lys Ile 
            260                 265                 270         


Ile Lys Met Leu Leu Ile Val Ala Leu Leu Phe Ile Leu Ser Trp Leu 
        275                 280                 285             


Pro Leu Trp Thr Leu Met Met Leu Ser Asp Tyr Ala Asp Leu Ser Pro 
    290                 295                 300                 


Asn Glu Leu Gln Ile Ile Asn Ile Tyr Ile Tyr Pro Phe Ala His Trp 
305                 310                 315                 320 


Leu Ala Phe Gly Asn Ser Ser Val Asn Pro Ile Ile Tyr Gly Phe Phe 
                325                 330                 335     


Asn Glu Asn Phe Arg Arg Gly Phe Gln Glu Ala Phe Gln Leu Gln Leu 
            340                 345                 350         


Cys Gln Lys Arg Ala Lys Pro Met Glu Ala Tyr Ala Leu Lys Ala Lys 
        355                 360                 365             


Ser His Val Leu Ile Asn Thr Ser Asn Gln Leu Val Gln Glu Ser Thr 
    370                 375                 380                 


Phe Gln Asn Pro His Gly Glu Thr Leu Leu Tyr Arg Lys Ser Ala Glu 
385                 390                 395                 400 


Lys Pro Gln Gln Glu Leu Val Met Glu Glu Leu Lys Glu Thr Thr Asn 
                405                 410                 415     


Ser Ser Glu Ile 
            420 


<210>  9453
<211>  522
<212>  PRT
<213>  Homo Sapiens

<400>  9453

Met Asn Ser Phe Phe Gly Thr Pro Ala Ala Ser Trp Cys Leu Leu Glu 
1               5                   10                  15      


Ser Asp Val Ser Ser Ala Pro Asp Lys Glu Ala Gly Arg Glu Arg Arg 
            20                  25                  30          


Ala Leu Ser Val Gln Gln Arg Gly Gly Pro Ala Trp Ser Gly Ser Leu 
        35                  40                  45              


Glu Trp Ser Arg Gln Ser Ala Gly Asp Arg Arg Arg Leu Gly Leu Ser 
    50                  55                  60                  


Arg Gln Thr Ala Lys Ser Ser Trp Ser Arg Ser Arg Asp Arg Thr Cys 
65                  70                  75                  80  


Cys Cys Arg Arg Ala Trp Trp Ile Leu Val Pro Ala Ala Asp Arg Ala 
                85                  90                  95      


Arg Arg Glu Arg Phe Ile Met Asn Glu Lys Trp Asp Thr Asn Ser Ser 
            100                 105                 110         


Glu Asn Trp His Pro Ile Trp Asn Val Asn Asp Thr Lys His His Leu 
        115                 120                 125             


Tyr Ser Asp Ile Asn Ile Thr Tyr Val Asn Tyr Tyr Leu His Gln Pro 
    130                 135                 140                 


Gln Val Ala Ala Ile Phe Ile Ile Ser Tyr Phe Leu Ile Phe Phe Leu 
145                 150                 155                 160 


Cys Met Met Gly Asn Thr Val Val Cys Phe Ile Val Met Arg Asn Lys 
                165                 170                 175     


His Met His Thr Val Thr Asn Leu Phe Ile Leu Asn Leu Ala Ile Ser 
            180                 185                 190         


Asp Leu Leu Val Gly Ile Phe Cys Met Pro Ile Thr Leu Leu Asp Asn 
        195                 200                 205             


Ile Ile Ala Gly Trp Pro Phe Gly Asn Thr Met Cys Lys Ile Ser Gly 
    210                 215                 220                 


Leu Val Gln Gly Ile Ser Val Ala Ala Ser Val Phe Thr Leu Val Ala 
225                 230                 235                 240 


Ile Ala Val Asp Arg Phe Gln Cys Val Val Tyr Pro Phe Lys Pro Lys 
                245                 250                 255     


Leu Thr Ile Lys Thr Ala Phe Val Ile Ile Met Ile Ile Trp Val Leu 
            260                 265                 270         


Ala Ile Thr Ile Met Ser Pro Ser Ala Val Met Leu His Val Gln Glu 
        275                 280                 285             


Glu Lys Tyr Tyr Arg Val Arg Leu Asn Ser Gln Asn Lys Thr Ser Pro 
    290                 295                 300                 


Val Tyr Trp Cys Arg Glu Asp Trp Pro Asn Gln Glu Met Arg Lys Ile 
305                 310                 315                 320 


Tyr Thr Thr Val Leu Phe Ala Asn Ile Tyr Leu Ala Pro Leu Ser Leu 
                325                 330                 335     


Ile Val Ile Met Tyr Gly Arg Ile Gly Ile Ser Leu Phe Arg Ala Ala 
            340                 345                 350         


Val Pro His Thr Gly Arg Lys Asn Gln Glu Gln Trp His Val Val Ser 
        355                 360                 365             


Arg Lys Lys Gln Lys Ile Ile Lys Met Leu Leu Ile Val Ala Leu Leu 
    370                 375                 380                 


Phe Ile Leu Ser Trp Leu Pro Leu Trp Thr Leu Met Met Leu Ser Asp 
385                 390                 395                 400 


Tyr Ala Asp Leu Ser Pro Asn Glu Leu Gln Ile Ile Asn Ile Tyr Ile 
                405                 410                 415     


Tyr Pro Phe Ala His Trp Leu Ala Phe Gly Asn Ser Ser Val Asn Pro 
            420                 425                 430         


Ile Ile Tyr Gly Phe Phe Asn Glu Asn Phe Arg Arg Gly Phe Gln Glu 
        435                 440                 445             


Ala Phe Gln Leu Gln Leu Cys Gln Lys Arg Ala Lys Pro Met Glu Ala 
    450                 455                 460                 


Tyr Ala Leu Lys Ala Lys Ser His Val Leu Ile Asn Thr Ser Asn Gln 
465                 470                 475                 480 


Leu Val Gln Glu Ser Thr Phe Gln Asn Pro His Gly Glu Thr Leu Leu 
                485                 490                 495     


Tyr Arg Lys Ser Ala Glu Lys Pro Gln Gln Glu Leu Val Met Glu Glu 
            500                 505                 510         


Leu Lys Glu Thr Thr Asn Ser Ser Glu Ile 
        515                 520         


<210>  9454
<211>  132
<212>  PRT
<213>  Homo Sapiens

<400>  9454

Met Asn Ser Phe Phe Gly Thr Pro Ala Ala Ser Trp Cys Leu Leu Glu 
1               5                   10                  15      


Ser Asp Val Ser Ser Ala Pro Asp Lys Glu Ala Gly Arg Glu Arg Arg 
            20                  25                  30          


Ala Leu Ser Val Gln Gln Arg Gly Gly Pro Ala Trp Ser Gly Ser Leu 
        35                  40                  45              


Glu Trp Ser Arg Gln Ser Ala Gly Asp Arg Arg Arg Leu Gly Leu Ser 
    50                  55                  60                  


Arg Gln Thr Ala Lys Ser Ser Trp Ser Arg Ser Arg Asp Arg Thr Cys 
65                  70                  75                  80  


Cys Cys Arg Arg Ala Trp Trp Ile Leu Val Pro Ala Ala Asp Arg Ala 
                85                  90                  95      


Arg Arg Glu Arg Met Ala Ile Trp Lys His Asp Val Gln Asp Gln Trp 
            100                 105                 110         


Ile Gly Pro Gly Asn Ile Cys Arg Ser Phe Ser Leu Tyr Val Ser Cys 
        115                 120                 125             


Asn Cys Cys Arg 
    130         


<210>  9455
<211>  1201
<212>  PRT
<213>  Homo Sapiens

<400>  9455

Met Ala Leu Gly Thr Thr Leu Arg Ala Ser Leu Leu Leu Leu Gly Leu 
1               5                   10                  15      


Leu Thr Glu Gly Leu Ala Gln Leu Ala Ile Pro Ala Ser Val Pro Arg 
            20                  25                  30          


Gly Phe Trp Ala Leu Pro Glu Asn Leu Thr Val Val Glu Gly Ala Ser 
        35                  40                  45              


Val Glu Leu Arg Cys Gly Val Ser Thr Pro Gly Ser Ala Val Gln Trp 
    50                  55                  60                  


Ala Lys Asp Gly Leu Leu Leu Gly Pro Asp Pro Arg Ile Pro Gly Phe 
65                  70                  75                  80  


Pro Arg Tyr Arg Leu Glu Gly Asp Pro Ala Arg Gly Glu Phe His Leu 
                85                  90                  95      


His Ile Glu Ala Cys Asp Leu Ser Asp Asp Ala Glu Tyr Glu Cys Gln 
            100                 105                 110         


Val Gly Arg Ser Glu Met Gly Pro Glu Leu Val Ser Pro Arg Val Ile 
        115                 120                 125             


Leu Ser Ile Leu Val Pro Pro Lys Leu Leu Leu Leu Thr Pro Glu Ala 
    130                 135                 140                 


Gly Thr Met Val Thr Trp Val Ala Gly Gln Glu Tyr Val Val Asn Cys 
145                 150                 155                 160 


Val Ser Gly Asp Ala Lys Pro Ala Pro Asp Ile Thr Ile Leu Leu Ser 
                165                 170                 175     


Gly Gln Thr Ile Ser Asp Ile Ser Ala Asn Val Asn Glu Gly Ser Gln 
            180                 185                 190         


Gln Lys Leu Phe Thr Val Glu Ala Thr Ala Arg Val Thr Pro Arg Ser 
        195                 200                 205             


Ser Asp Asn Arg Gln Leu Leu Val Cys Glu Ala Ser Ser Pro Ala Leu 
    210                 215                 220                 


Glu Ala Pro Ile Lys Ala Ser Phe Thr Val Asn Val Leu Phe Pro Pro 
225                 230                 235                 240 


Gly Pro Pro Val Ile Glu Trp Pro Gly Leu Asp Glu Gly His Val Arg 
                245                 250                 255     


Ala Gly Gln Ser Leu Glu Leu Pro Cys Val Ala Arg Gly Gly Asn Pro 
            260                 265                 270         


Leu Ala Thr Leu Gln Trp Leu Lys Asn Gly Gln Pro Val Ser Thr Ala 
        275                 280                 285             


Trp Gly Thr Glu His Thr Gln Ala Val Ala Arg Ser Val Leu Val Met 
    290                 295                 300                 


Thr Val Arg Pro Glu Asp His Gly Ala Gln Leu Ser Cys Glu Ala His 
305                 310                 315                 320 


Asn Ser Val Ser Ala Gly Thr Gln Glu His Gly Ile Thr Leu Gln Val 
                325                 330                 335     


Thr Phe Pro Pro Ser Ala Ile Ile Ile Leu Gly Ser Ala Ser Gln Thr 
            340                 345                 350         


Glu Asn Lys Asn Val Thr Leu Ser Cys Val Ser Lys Ser Ser Arg Pro 
        355                 360                 365             


Arg Val Leu Leu Arg Trp Trp Leu Gly Trp Arg Gln Leu Leu Pro Met 
    370                 375                 380                 


Glu Glu Thr Val Met Asp Gly Leu His Gly Gly His Ile Ser Met Ser 
385                 390                 395                 400 


Asn Leu Thr Phe Leu Ala Arg Arg Glu Asp Asn Gly Leu Thr Leu Thr 
                405                 410                 415     


Cys Glu Ala Phe Ser Glu Ala Phe Thr Lys Glu Thr Phe Lys Lys Ser 
            420                 425                 430         


Leu Ile Leu Asn Val Lys Tyr Pro Ala Gln Lys Leu Trp Ile Glu Gly 
        435                 440                 445             


Pro Pro Glu Gly Gln Lys Leu Arg Ala Gly Thr Arg Val Arg Leu Val 
    450                 455                 460                 


Cys Leu Ala Ile Gly Gly Asn Pro Glu Pro Ser Leu Met Trp Tyr Lys 
465                 470                 475                 480 


Asp Ser Arg Thr Val Thr Glu Ser Arg Leu Pro Gln Glu Ser Arg Arg 
                485                 490                 495     


Val His Leu Gly Ser Val Glu Lys Ser Gly Ser Thr Phe Ser Arg Glu 
            500                 505                 510         


Leu Val Leu Val Thr Gly Pro Ser Asp Asn Gln Ala Lys Phe Thr Cys 
        515                 520                 525             


Lys Ala Gly Gln Leu Ser Ala Ser Thr Gln Leu Ala Val Gln Phe Pro 
    530                 535                 540                 


Pro Thr Asn Val Thr Ile Leu Ala Asn Ala Ser Ala Leu Arg Pro Gly 
545                 550                 555                 560 


Asp Ala Leu Asn Leu Thr Cys Val Ser Val Ser Ser Asn Pro Pro Val 
                565                 570                 575     


Asn Leu Ser Trp Asp Lys Glu Gly Glu Arg Leu Glu Gly Val Ala Ala 
            580                 585                 590         


Pro Pro Arg Arg Ala Pro Phe Lys Gly Ser Ala Ala Ala Arg Ser Val 
        595                 600                 605             


Leu Leu Gln Val Ser Ser Arg Asp His Gly Gln Arg Val Thr Cys Arg 
    610                 615                 620                 


Ala His Ser Ala Glu Leu Arg Glu Thr Val Ser Ser Phe Tyr Arg Leu 
625                 630                 635                 640 


Asn Val Leu Tyr Arg Pro Glu Phe Leu Gly Glu Gln Val Leu Val Val 
                645                 650                 655     


Thr Ala Val Glu Gln Gly Glu Ala Leu Leu Pro Val Ser Val Ser Ala 
            660                 665                 670         


Asn Pro Ala Pro Glu Ala Phe Asn Trp Thr Phe Arg Gly Tyr Arg Leu 
        675                 680                 685             


Ser Pro Ala Gly Gly Pro Arg His Arg Ile Leu Ser Ser Gly Ala Leu 
    690                 695                 700                 


His Leu Trp Asn Val Thr Arg Ala Asp Asp Gly Leu Tyr Gln Leu His 
705                 710                 715                 720 


Cys Gln Asn Ser Glu Gly Thr Ala Glu Ala Arg Leu Arg Leu Asp Val 
                725                 730                 735     


His Tyr Ala Pro Thr Ile Arg Ala Leu Gln Asp Pro Thr Glu Val Asn 
            740                 745                 750         


Val Gly Gly Ser Val Asp Ile Val Cys Thr Val Asp Ala Asn Pro Ile 
        755                 760                 765             


Leu Pro Gly Met Phe Asn Trp Glu Arg Leu Gly Glu Asp Glu Glu Asp 
    770                 775                 780                 


Gln Ser Leu Asp Asp Met Glu Lys Ile Ser Arg Gly Pro Thr Gly Arg 
785                 790                 795                 800 


Leu Arg Ile His His Ala Lys Leu Ala Gln Ala Gly Ala Tyr Gln Cys 
                805                 810                 815     


Ile Val Asp Asn Gly Val Ala Pro Pro Ala Arg Arg Leu Leu Arg Leu 
            820                 825                 830         


Val Val Arg Phe Ala Pro Gln Val Glu His Pro Thr Pro Leu Thr Lys 
        835                 840                 845             


Val Ala Ala Ala Gly Asp Ser Thr Ser Ser Ala Thr Leu His Cys Arg 
    850                 855                 860                 


Ala Arg Gly Val Pro Asn Ile Val Phe Thr Trp Thr Lys Asn Gly Val 
865                 870                 875                 880 


Pro Leu Asp Leu Gln Asp Pro Arg Tyr Thr Glu His Thr Tyr His Gln 
                885                 890                 895     


Gly Gly Val His Ser Ser Leu Leu Thr Ile Ala Asn Val Ser Ala Ala 
            900                 905                 910         


Gln Asp Tyr Ala Leu Phe Thr Cys Thr Ala Thr Asn Ala Leu Gly Ser 
        915                 920                 925             


Asp Gln Thr Asn Ile Gln Leu Val Ser Ile Ser Arg Pro Asp Pro Pro 
    930                 935                 940                 


Ser Gly Leu Lys Val Val Ser Leu Thr Pro His Ser Val Gly Leu Glu 
945                 950                 955                 960 


Trp Lys Pro Gly Phe Asp Gly Gly Leu Pro Gln Arg Phe Cys Ile Arg 
                965                 970                 975     


Tyr Glu Ala Leu Gly Thr Pro Gly Phe His Tyr Val Asp Val Val Pro 
            980                 985                 990         


Pro Gln Ala Thr Thr Phe Thr Leu  Thr Gly Leu Gln Pro  Ser Thr Arg 
        995                 1000                 1005             


Tyr Arg  Val Trp Leu Leu Ala  Ser Asn Ala Leu Gly  Asp Ser Gly 
    1010                 1015                 1020             


Leu Ala  Asp Lys Gly Thr Gln  Leu Pro Ile Thr Thr  Pro Gly Leu 
    1025                 1030                 1035             


His Gln  Pro Ser Gly Glu Pro  Glu Asp Gln Leu Pro  Thr Glu Pro 
    1040                 1045                 1050             


Pro Ser  Gly Ile Ser Glu Lys  Thr Glu Ala Gly Ser  Glu Glu Asp 
    1055                 1060                 1065             


Arg Val  Arg Asn Glu Tyr Glu  Glu Ser Gln Trp Thr  Gly Glu Arg 
    1070                 1075                 1080             


Asp Thr  Gln Ser Ser Thr Val  Ser Thr Thr Glu Ala  Glu Pro Tyr 
    1085                 1090                 1095             


Tyr Arg  Ser Leu Arg Asp Phe  Ser Pro Gln Leu Pro  Pro Thr Gln 
    1100                 1105                 1110             


Glu Glu  Val Ser Tyr Ser Arg  Gly Phe Thr Gly Glu  Asp Glu Asp 
    1115                 1120                 1125             


Met Ala  Phe Pro Gly His Leu  Tyr Asp Glu Val Glu  Arg Thr Tyr 
    1130                 1135                 1140             


Pro Pro  Ser Gly Ala Trp Gly  Pro Leu Tyr Asp Glu  Val Gln Met 
    1145                 1150                 1155             


Gly Pro  Trp Asp Leu His Trp  Pro Glu Asp Thr Tyr  Gln Asp Pro 
    1160                 1165                 1170             


Arg Gly  Ile Tyr Asp Gln Val  Ala Gly Asp Leu Asp  Thr Leu Glu 
    1175                 1180                 1185             


Pro Asp  Ser Leu Pro Phe Glu  Leu Arg Gly His Leu  Val 
    1190                 1195                 1200     


<210>  9456
<211>  1241
<212>  PRT
<213>  Homo Sapiens

<400>  9456

Met Ala Leu Gly Thr Thr Leu Arg Ala Ser Leu Leu Leu Leu Gly Leu 
1               5                   10                  15      


Leu Thr Glu Gly Leu Ala Gln Leu Ala Ile Pro Ala Ser Val Pro Arg 
            20                  25                  30          


Gly Phe Trp Ala Leu Pro Glu Asn Leu Thr Val Val Glu Gly Ala Ser 
        35                  40                  45              


Val Glu Leu Arg Cys Gly Val Ser Thr Pro Gly Ser Ala Val Gln Trp 
    50                  55                  60                  


Ala Lys Asp Gly Leu Leu Leu Gly Pro Asp Pro Arg Ile Pro Gly Phe 
65                  70                  75                  80  


Pro Arg Tyr Arg Leu Glu Gly Asp Pro Ala Arg Gly Glu Phe His Leu 
                85                  90                  95      


His Ile Glu Ala Cys Asp Leu Ser Asp Asp Ala Glu Tyr Glu Cys Gln 
            100                 105                 110         


Val Gly Arg Ser Glu Met Gly Pro Glu Leu Val Ser Pro Arg Val Ile 
        115                 120                 125             


Leu Ser Ile Leu Val Pro Pro Lys Leu Leu Leu Leu Thr Pro Glu Ala 
    130                 135                 140                 


Gly Thr Met Val Thr Trp Val Ala Gly Gln Glu Tyr Val Val Asn Cys 
145                 150                 155                 160 


Val Ser Gly Asp Ala Lys Pro Ala Pro Asp Ile Thr Ile Leu Leu Ser 
                165                 170                 175     


Gly Gln Thr Ile Ser Asp Ile Ser Ala Asn Val Asn Glu Gly Ser Gln 
            180                 185                 190         


Gln Lys Leu Phe Thr Val Glu Ala Thr Ala Arg Val Thr Pro Arg Ser 
        195                 200                 205             


Ser Asp Asn Arg Gln Leu Leu Val Cys Glu Ala Ser Ser Pro Ala Leu 
    210                 215                 220                 


Glu Ala Pro Ile Lys Ala Ser Phe Thr Val Asn Val Leu Phe Pro Pro 
225                 230                 235                 240 


Gly Pro Pro Val Ile Glu Trp Pro Gly Leu Asp Glu Gly His Val Arg 
                245                 250                 255     


Ala Gly Gln Ser Leu Glu Leu Pro Cys Val Ala Arg Gly Gly Asn Pro 
            260                 265                 270         


Leu Ala Thr Leu Gln Trp Leu Lys Asn Gly Gln Pro Val Ser Thr Ala 
        275                 280                 285             


Trp Gly Thr Glu His Thr Gln Ala Val Ala Arg Ser Val Leu Val Met 
    290                 295                 300                 


Thr Val Arg Pro Glu Asp His Gly Ala Gln Leu Ser Cys Glu Ala His 
305                 310                 315                 320 


Asn Ser Val Ser Ala Gly Thr Gln Glu His Gly Ile Thr Leu Gln Val 
                325                 330                 335     


Thr Phe Pro Pro Ser Ala Ile Ile Ile Leu Gly Ser Ala Ser Gln Thr 
            340                 345                 350         


Glu Asn Lys Asn Val Thr Leu Ser Cys Val Ser Lys Ser Ser Arg Pro 
        355                 360                 365             


Arg Val Leu Leu Arg Trp Trp Leu Gly Trp Arg Gln Leu Leu Pro Met 
    370                 375                 380                 


Glu Glu Thr Val Met Asp Gly Leu His Gly Gly His Ile Ser Met Ser 
385                 390                 395                 400 


Asn Leu Thr Phe Leu Ala Arg Arg Glu Asp Asn Gly Leu Thr Leu Thr 
                405                 410                 415     


Cys Glu Ala Phe Ser Glu Ala Phe Thr Lys Glu Thr Phe Lys Lys Ser 
            420                 425                 430         


Leu Ile Leu Asn Val Lys Tyr Pro Ala Gln Lys Leu Trp Ile Glu Gly 
        435                 440                 445             


Pro Pro Glu Gly Gln Lys Leu Arg Ala Gly Thr Arg Val Arg Leu Val 
    450                 455                 460                 


Cys Leu Ala Ile Gly Gly Asn Pro Glu Pro Ser Leu Met Trp Tyr Lys 
465                 470                 475                 480 


Asp Ser Arg Thr Val Thr Glu Ser Arg Leu Pro Gln Glu Ser Arg Arg 
                485                 490                 495     


Val His Leu Gly Ser Val Glu Lys Ser Gly Ser Thr Phe Ser Arg Glu 
            500                 505                 510         


Leu Val Leu Val Thr Gly Pro Ser Asp Asn Gln Ala Lys Phe Thr Cys 
        515                 520                 525             


Lys Ala Gly Gln Leu Ser Ala Ser Thr Gln Leu Ala Val Gln Phe Pro 
    530                 535                 540                 


Pro Thr Asn Val Thr Ile Leu Ala Asn Ala Ser Ala Leu Arg Pro Gly 
545                 550                 555                 560 


Asp Ala Leu Asn Leu Thr Cys Val Ser Val Ser Ser Asn Pro Pro Val 
                565                 570                 575     


Asn Leu Ser Trp Asp Lys Glu Gly Glu Arg Leu Glu Gly Val Ala Ala 
            580                 585                 590         


Pro Pro Arg Arg Ala Pro Phe Lys Gly Ser Ala Ala Ala Arg Ser Val 
        595                 600                 605             


Leu Leu Gln Val Ser Ser Arg Asp His Gly Gln Arg Val Thr Cys Arg 
    610                 615                 620                 


Ala His Ser Ala Glu Leu Arg Glu Thr Val Ser Ser Phe Tyr Arg Leu 
625                 630                 635                 640 


Asn Val Leu Tyr Arg Pro Glu Phe Leu Gly Glu Gln Val Leu Val Val 
                645                 650                 655     


Thr Ala Val Glu Gln Gly Glu Ala Leu Leu Pro Val Ser Val Ser Ala 
            660                 665                 670         


Asn Pro Ala Pro Glu Ala Phe Asn Trp Thr Phe Arg Gly Tyr Arg Leu 
        675                 680                 685             


Ser Pro Ala Gly Gly Pro Arg His Arg Ile Leu Ser Ser Gly Ala Leu 
    690                 695                 700                 


His Leu Trp Asn Val Thr Arg Ala Asp Asp Gly Leu Tyr Gln Leu His 
705                 710                 715                 720 


Cys Gln Asn Ser Glu Gly Thr Ala Glu Ala Arg Leu Arg Leu Asp Val 
                725                 730                 735     


His Tyr Ala Pro Thr Ile Arg Ala Leu Gln Asp Pro Thr Glu Val Asn 
            740                 745                 750         


Val Gly Gly Ser Val Asp Ile Val Cys Thr Val Asp Ala Asn Pro Ile 
        755                 760                 765             


Leu Pro Gly Met Phe Asn Trp Glu Arg Leu Gly Glu Asp Glu Glu Asp 
    770                 775                 780                 


Gln Ser Leu Asp Asp Met Glu Lys Ile Ser Arg Gly Pro Thr Gly Arg 
785                 790                 795                 800 


Leu Arg Ile His His Ala Lys Leu Ala Gln Ala Gly Ala Tyr Gln Cys 
                805                 810                 815     


Ile Val Asp Asn Gly Val Ala Pro Pro Ala Arg Arg Leu Leu Arg Leu 
            820                 825                 830         


Val Val Arg Phe Ala Pro Gln Val Glu His Pro Thr Pro Leu Thr Lys 
        835                 840                 845             


Val Ala Ala Ala Gly Asp Ser Thr Ser Ser Ala Thr Leu His Cys Arg 
    850                 855                 860                 


Ala Arg Gly Val Pro Asn Ile Val Phe Thr Trp Thr Lys Asn Gly Val 
865                 870                 875                 880 


Pro Leu Asp Leu Gln Asp Pro Arg Tyr Thr Glu His Thr Tyr His Gln 
                885                 890                 895     


Gly Gly Val His Ser Ser Leu Leu Thr Ile Ala Asn Val Ser Ala Ala 
            900                 905                 910         


Gln Asp Tyr Ala Leu Phe Thr Cys Thr Ala Thr Asn Ala Leu Gly Ser 
        915                 920                 925             


Asp Gln Thr Asn Ile Gln Leu Val Ser Ile Ser Arg Pro Asp Pro Pro 
    930                 935                 940                 


Ser Gly Leu Lys Val Val Ser Leu Thr Pro His Ser Val Gly Leu Glu 
945                 950                 955                 960 


Trp Lys Pro Gly Phe Asp Gly Gly Leu Pro Gln Arg Phe Cys Ile Arg 
                965                 970                 975     


Tyr Glu Ala Leu Gly Thr Pro Gly Phe His Tyr Val Asp Val Val Pro 
            980                 985                 990         


Pro Gln Ala Thr Thr Phe Thr Leu  Thr Gly Leu Gln Pro  Ser Thr Arg 
        995                 1000                 1005             


Tyr Arg  Val Trp Leu Leu Ala  Ser Asn Ala Leu Gly  Asp Ser Gly 
    1010                 1015                 1020             


Leu Ala  Asp Lys Gly Thr Gln  Leu Pro Ile Thr Thr  Pro Gly Leu 
    1025                 1030                 1035             


His Gln  Pro Ser Gly Glu Pro  Glu Asp Gln Leu Pro  Thr Glu Pro 
    1040                 1045                 1050             


Pro Ser  Gly Pro Ser Gly Leu  Pro Leu Leu Pro Val  Leu Phe Ala 
    1055                 1060                 1065             


Leu Gly  Gly Leu Leu Leu Leu  Ser Asn Ala Ser Cys  Val Gly Gly 
    1070                 1075                 1080             


Val Leu  Trp Gln Arg Arg Leu  Arg Arg Leu Ala Glu  Gly Ile Ser 
    1085                 1090                 1095             


Glu Lys  Thr Glu Ala Gly Ser  Glu Glu Asp Arg Val  Arg Asn Glu 
    1100                 1105                 1110             


Tyr Glu  Glu Ser Gln Trp Thr  Gly Glu Arg Asp Thr  Gln Ser Ser 
    1115                 1120                 1125             


Thr Val  Ser Thr Thr Glu Ala  Glu Pro Tyr Tyr Arg  Ser Leu Arg 
    1130                 1135                 1140             


Asp Phe  Ser Pro Gln Leu Pro  Pro Thr Gln Glu Glu  Val Ser Tyr 
    1145                 1150                 1155             


Ser Arg  Gly Phe Thr Gly Glu  Asp Glu Asp Met Ala  Phe Pro Gly 
    1160                 1165                 1170             


His Leu  Tyr Asp Glu Val Glu  Arg Thr Tyr Pro Pro  Ser Gly Ala 
    1175                 1180                 1185             


Trp Gly  Pro Leu Tyr Asp Glu  Val Gln Met Gly Pro  Trp Asp Leu 
    1190                 1195                 1200             


His Trp  Pro Glu Asp Thr Tyr  Gln Asp Pro Arg Gly  Ile Tyr Asp 
    1205                 1210                 1215             


Gln Val  Ala Gly Asp Leu Asp  Thr Leu Glu Pro Asp  Ser Leu Pro 
    1220                 1225                 1230             


Phe Glu  Leu Arg Gly His Leu  Val 
    1235                 1240     


<210>  9457
<211>  609
<212>  PRT
<213>  Homo Sapiens

<400>  9457

Met Asp Phe Leu Leu Ala Leu Val Leu Val Ser Ser Leu Tyr Leu Gln 
1               5                   10                  15      


Ala Ala Ala Glu Phe Asp Gly Arg Trp Pro Arg Gln Ile Val Ser Ser 
            20                  25                  30          


Ile Gly Leu Cys Arg Tyr Gly Gly Arg Ile Asp Cys Cys Trp Gly Trp 
        35                  40                  45              


Ala Arg Gln Ser Trp Gly Gln Cys Gln Pro Phe Tyr Val Leu Arg Gln 
    50                  55                  60                  


Arg Ile Ala Arg Ile Arg Cys Gln Leu Lys Ala Val Cys Gln Pro Arg 
65                  70                  75                  80  


Cys Lys His Gly Glu Cys Ile Gly Pro Asn Lys Cys Lys Cys His Pro 
                85                  90                  95      


Gly Tyr Ala Gly Lys Thr Cys Asn Gln Asp Glu His Ile Pro Ala Pro 
            100                 105                 110         


Leu Asp Gln Gly Ser Glu Gln Pro Leu Phe Gln Pro Leu Asp His Gln 
        115                 120                 125             


Ala Thr Ser Leu Pro Ser Arg Asp Leu Asn Glu Cys Gly Leu Lys Pro 
    130                 135                 140                 


Arg Pro Cys Lys His Arg Cys Met Asn Thr Tyr Gly Ser Tyr Lys Cys 
145                 150                 155                 160 


Tyr Cys Leu Asn Gly Tyr Met Leu Met Pro Asp Gly Ser Cys Ser Ser 
                165                 170                 175     


Ala Leu Thr Cys Ser Met Ala Asn Cys Gln Tyr Gly Cys Asp Val Val 
            180                 185                 190         


Lys Gly Gln Ile Arg Cys Gln Cys Pro Ser Pro Gly Leu Gln Leu Ala 
        195                 200                 205             


Pro Asp Gly Arg Thr Cys Val Asp Val Asp Glu Cys Ala Thr Gly Arg 
    210                 215                 220                 


Ala Ser Cys Pro Arg Phe Arg Gln Cys Val Asn Thr Phe Gly Ser Tyr 
225                 230                 235                 240 


Ile Cys Lys Cys His Lys Gly Phe Asp Leu Met Tyr Ile Gly Gly Lys 
                245                 250                 255     


Tyr Gln Cys His Asp Ile Asp Glu Cys Ser Leu Gly Gln Tyr Gln Cys 
            260                 265                 270         


Ser Ser Phe Ala Arg Cys Tyr Asn Ile Arg Gly Ser Tyr Lys Cys Lys 
        275                 280                 285             


Cys Lys Glu Gly Tyr Gln Gly Asp Gly Leu Thr Cys Val Tyr Ile Pro 
    290                 295                 300                 


Lys Val Met Ile Glu Pro Ser Gly Pro Ile His Val Pro Lys Gly Asn 
305                 310                 315                 320 


Gly Thr Ile Leu Lys Gly Asp Thr Gly Asn Asn Asn Trp Ile Pro Asp 
                325                 330                 335     


Val Gly Ser Thr Trp Trp Pro Pro Lys Thr Pro Tyr Ile Pro Pro Ile 
            340                 345                 350         


Ile Thr Asn Arg Pro Thr Ser Lys Pro Thr Thr Arg Pro Thr Pro Lys 
        355                 360                 365             


Pro Thr Pro Ile Pro Thr Pro Pro Pro Pro Pro Pro Leu Pro Thr Glu 
    370                 375                 380                 


Leu Arg Thr Pro Leu Pro Pro Thr Thr Pro Glu Arg Pro Thr Thr Gly 
385                 390                 395                 400 


Leu Thr Thr Ile Ala Pro Ala Ala Ser Thr Pro Pro Gly Gly Ile Thr 
                405                 410                 415     


Val Asp Asn Arg Val Gln Thr Asp Pro Gln Lys Pro Arg Gly Asp Val 
            420                 425                 430         


Phe Ile Pro Arg Gln Pro Ser Asn Asp Leu Phe Glu Ile Phe Glu Ile 
        435                 440                 445             


Glu Arg Gly Val Ser Ala Asp Asp Glu Ala Lys Asp Asp Pro Gly Val 
    450                 455                 460                 


Leu Val His Ser Cys Asn Phe Asp His Gly Leu Cys Gly Trp Ile Arg 
465                 470                 475                 480 


Glu Lys Asp Asn Asp Leu His Trp Glu Pro Ile Arg Asp Pro Ala Gly 
                485                 490                 495     


Gly Gln Tyr Leu Thr Val Ser Ala Ala Lys Ala Pro Gly Gly Lys Ala 
            500                 505                 510         


Ala Arg Leu Val Leu Pro Leu Gly Arg Leu Met His Ser Gly Asp Leu 
        515                 520                 525             


Cys Leu Ser Phe Arg His Lys Val Thr Gly Leu His Ser Gly Thr Leu 
    530                 535                 540                 


Gln Val Phe Val Arg Lys His Gly Ala His Gly Ala Ala Leu Trp Gly 
545                 550                 555                 560 


Arg Asn Gly Gly His Gly Trp Arg Gln Thr Gln Ile Thr Leu Arg Gly 
                565                 570                 575     


Ala Asp Ile Lys Ser Val Val Phe Lys Gly Glu Lys Arg Arg Gly His 
            580                 585                 590         


Thr Gly Glu Ile Gly Leu Asp Asp Val Ser Leu Lys Lys Gly His Cys 
        595                 600                 605             


Ser 
    


<210>  9458
<211>  582
<212>  PRT
<213>  Homo Sapiens

<400>  9458

Met Asp Phe Leu Leu Ala Leu Val Leu Val Ser Ser Leu Tyr Leu Gln 
1               5                   10                  15      


Ala Ala Ala Glu Phe Asp Gly Arg Trp Pro Arg Gln Ile Val Ser Ser 
            20                  25                  30          


Ile Gly Leu Cys Arg Tyr Gly Gly Arg Ile Asp Cys Cys Trp Gly Trp 
        35                  40                  45              


Ala Arg Gln Ser Trp Gly Gln Cys Gln Pro Phe Tyr Val Leu Arg Gln 
    50                  55                  60                  


Arg Ile Ala Arg Ile Arg Cys Gln Leu Lys Ala Val Cys Gln Pro Arg 
65                  70                  75                  80  


Cys Lys His Gly Glu Cys Ile Gly Pro Asn Lys Cys Lys Cys His Pro 
                85                  90                  95      


Gly Tyr Ala Gly Lys Thr Cys Asn Gln Asp Leu Asn Glu Cys Gly Leu 
            100                 105                 110         


Lys Pro Arg Pro Cys Lys His Arg Cys Met Asn Thr Tyr Gly Ser Tyr 
        115                 120                 125             


Lys Cys Tyr Cys Leu Asn Gly Tyr Met Leu Met Pro Asp Gly Ser Cys 
    130                 135                 140                 


Ser Ser Ala Leu Thr Cys Ser Met Ala Asn Cys Gln Tyr Gly Cys Asp 
145                 150                 155                 160 


Val Val Lys Gly Gln Ile Arg Cys Gln Cys Pro Ser Pro Gly Leu Gln 
                165                 170                 175     


Leu Ala Pro Asp Gly Arg Thr Cys Val Asp Val Asp Glu Cys Ala Thr 
            180                 185                 190         


Gly Arg Ala Ser Cys Pro Arg Phe Arg Gln Cys Val Asn Thr Phe Gly 
        195                 200                 205             


Ser Tyr Ile Cys Lys Cys His Lys Gly Phe Asp Leu Met Tyr Ile Gly 
    210                 215                 220                 


Gly Lys Tyr Gln Cys His Asp Ile Asp Glu Cys Ser Leu Gly Gln Tyr 
225                 230                 235                 240 


Gln Cys Ser Ser Phe Ala Arg Cys Tyr Asn Ile Arg Gly Ser Tyr Lys 
                245                 250                 255     


Cys Lys Cys Lys Glu Gly Tyr Gln Gly Asp Gly Leu Thr Cys Val Tyr 
            260                 265                 270         


Ile Pro Lys Val Met Ile Glu Pro Ser Gly Pro Ile His Val Pro Lys 
        275                 280                 285             


Gly Asn Gly Thr Ile Leu Lys Gly Asp Thr Gly Asn Asn Asn Trp Ile 
    290                 295                 300                 


Pro Asp Val Gly Ser Thr Trp Trp Pro Pro Lys Thr Pro Tyr Ile Pro 
305                 310                 315                 320 


Pro Ile Ile Thr Asn Arg Pro Thr Ser Lys Pro Thr Thr Arg Pro Thr 
                325                 330                 335     


Pro Lys Pro Thr Pro Ile Pro Thr Pro Pro Pro Pro Pro Pro Leu Pro 
            340                 345                 350         


Thr Glu Leu Arg Thr Pro Leu Pro Pro Thr Thr Pro Glu Arg Pro Thr 
        355                 360                 365             


Thr Gly Leu Thr Thr Ile Ala Pro Ala Ala Ser Thr Pro Pro Gly Gly 
    370                 375                 380                 


Ile Thr Val Asp Asn Arg Val Gln Thr Asp Pro Gln Lys Pro Arg Gly 
385                 390                 395                 400 


Asp Val Phe Ile Pro Arg Gln Pro Ser Asn Asp Leu Phe Glu Ile Phe 
                405                 410                 415     


Glu Ile Glu Arg Gly Val Ser Ala Asp Asp Glu Ala Lys Asp Asp Pro 
            420                 425                 430         


Gly Val Leu Val His Ser Cys Asn Phe Asp His Gly Leu Cys Gly Trp 
        435                 440                 445             


Ile Arg Glu Lys Asp Asn Asp Leu His Trp Glu Pro Ile Arg Asp Pro 
    450                 455                 460                 


Ala Gly Gly Gln Tyr Leu Thr Val Ser Ala Ala Lys Ala Pro Gly Gly 
465                 470                 475                 480 


Lys Ala Ala Arg Leu Val Leu Pro Leu Gly Arg Leu Met His Ser Gly 
                485                 490                 495     


Asp Leu Cys Leu Ser Phe Arg His Lys Val Thr Gly Leu His Ser Gly 
            500                 505                 510         


Thr Leu Gln Val Phe Val Arg Lys His Gly Ala His Gly Ala Ala Leu 
        515                 520                 525             


Trp Gly Arg Asn Gly Gly His Gly Trp Arg Gln Thr Gln Ile Thr Leu 
    530                 535                 540                 


Arg Gly Ala Asp Ile Lys Ser Val Val Phe Lys Gly Glu Lys Arg Arg 
545                 550                 555                 560 


Gly His Thr Gly Glu Ile Gly Leu Asp Asp Val Ser Leu Lys Lys Gly 
                565                 570                 575     


His Cys Ser Glu Glu Arg 
            580         


<210>  9459
<211>  595
<212>  PRT
<213>  Homo Sapiens

<400>  9459

Met Asp Phe Leu Leu Ala Leu Val Leu Val Ser Ser Leu Tyr Leu Gln 
1               5                   10                  15      


Ala Ala Ala Glu Phe Asp Gly Arg Trp Pro Arg Gln Ile Val Ser Ser 
            20                  25                  30          


Ile Gly Leu Cys Arg Tyr Gly Gly Arg Ile Asp Cys Cys Trp Gly Trp 
        35                  40                  45              


Ala Arg Gln Ser Trp Gly Gln Cys Gln Pro Val Cys Gln Pro Arg Cys 
    50                  55                  60                  


Lys His Gly Glu Cys Ile Gly Pro Asn Lys Cys Lys Cys His Pro Gly 
65                  70                  75                  80  


Tyr Ala Gly Lys Thr Cys Asn Gln Asp Glu His Ile Pro Ala Pro Leu 
                85                  90                  95      


Asp Gln Gly Ser Glu Gln Pro Leu Phe Gln Pro Leu Asp His Gln Ala 
            100                 105                 110         


Thr Ser Leu Pro Ser Arg Asp Leu Asn Glu Cys Gly Leu Lys Pro Arg 
        115                 120                 125             


Pro Cys Lys His Arg Cys Met Asn Thr Tyr Gly Ser Tyr Lys Cys Tyr 
    130                 135                 140                 


Cys Leu Asn Gly Tyr Met Leu Met Pro Asp Gly Ser Cys Ser Ser Ala 
145                 150                 155                 160 


Leu Thr Cys Ser Met Ala Asn Cys Gln Tyr Gly Cys Asp Val Val Lys 
                165                 170                 175     


Gly Gln Ile Arg Cys Gln Cys Pro Ser Pro Gly Leu Gln Leu Ala Pro 
            180                 185                 190         


Asp Gly Arg Thr Cys Val Asp Val Asp Glu Cys Ala Thr Gly Arg Ala 
        195                 200                 205             


Ser Cys Pro Arg Phe Arg Gln Cys Val Asn Thr Phe Gly Ser Tyr Ile 
    210                 215                 220                 


Cys Lys Cys His Lys Gly Phe Asp Leu Met Tyr Ile Gly Gly Lys Tyr 
225                 230                 235                 240 


Gln Cys His Asp Ile Asp Glu Cys Ser Leu Gly Gln Tyr Gln Cys Ser 
                245                 250                 255     


Ser Phe Ala Arg Cys Tyr Asn Ile Arg Gly Ser Tyr Lys Cys Lys Cys 
            260                 265                 270         


Lys Glu Gly Tyr Gln Gly Asp Gly Leu Thr Cys Val Tyr Ile Pro Lys 
        275                 280                 285             


Val Met Ile Glu Pro Ser Gly Pro Ile His Val Pro Lys Gly Asn Gly 
    290                 295                 300                 


Thr Ile Leu Lys Gly Asp Thr Gly Asn Asn Asn Trp Ile Pro Asp Val 
305                 310                 315                 320 


Gly Ser Thr Trp Trp Pro Pro Lys Thr Pro Tyr Ile Pro Pro Ile Ile 
                325                 330                 335     


Thr Asn Arg Pro Thr Ser Lys Pro Thr Thr Arg Pro Thr Pro Lys Pro 
            340                 345                 350         


Thr Pro Ile Pro Thr Pro Pro Pro Pro Pro Pro Leu Pro Thr Glu Leu 
        355                 360                 365             


Arg Thr Pro Leu Pro Pro Thr Thr Pro Glu Arg Pro Thr Thr Gly Leu 
    370                 375                 380                 


Thr Thr Ile Ala Pro Ala Ala Ser Thr Pro Pro Gly Gly Ile Thr Val 
385                 390                 395                 400 


Asp Asn Arg Val Gln Thr Asp Pro Gln Lys Pro Arg Gly Asp Val Phe 
                405                 410                 415     


Ile Pro Arg Gln Pro Ser Asn Asp Leu Phe Glu Ile Phe Glu Ile Glu 
            420                 425                 430         


Arg Gly Val Ser Ala Asp Asp Glu Ala Lys Asp Asp Pro Gly Val Leu 
        435                 440                 445             


Val His Ser Cys Asn Phe Asp His Gly Leu Cys Gly Trp Ile Arg Glu 
    450                 455                 460                 


Lys Asp Asn Asp Leu His Trp Glu Pro Ile Arg Asp Pro Ala Gly Gly 
465                 470                 475                 480 


Gln Tyr Leu Thr Val Ser Ala Ala Lys Ala Pro Gly Gly Lys Ala Ala 
                485                 490                 495     


Arg Leu Val Leu Pro Leu Gly Arg Leu Met His Ser Gly Asp Leu Cys 
            500                 505                 510         


Leu Ser Phe Arg His Lys Val Thr Gly Leu His Ser Gly Thr Leu Gln 
        515                 520                 525             


Val Phe Val Arg Lys His Gly Ala His Gly Ala Ala Leu Trp Gly Arg 
    530                 535                 540                 


Asn Gly Gly His Gly Trp Arg Gln Thr Gln Ile Thr Leu Arg Gly Ala 
545                 550                 555                 560 


Asp Ile Lys Ser Val Val Phe Lys Gly Glu Lys Arg Arg Gly His Thr 
                565                 570                 575     


Gly Glu Ile Gly Leu Asp Asp Val Ser Leu Lys Lys Gly His Cys Ser 
            580                 585                 590         


Glu Glu Arg 
        595 


<210>  9460
<211>  566
<212>  PRT
<213>  Homo Sapiens

<400>  9460

Met Asp Phe Leu Leu Ala Leu Val Leu Val Ser Ser Leu Tyr Leu Gln 
1               5                   10                  15      


Ala Ala Ala Glu Phe Asp Gly Arg Trp Pro Arg Gln Ile Val Ser Ser 
            20                  25                  30          


Ile Gly Leu Cys Arg Tyr Gly Gly Arg Ile Asp Cys Cys Trp Gly Trp 
        35                  40                  45              


Ala Arg Gln Ser Trp Gly Gln Cys Gln Pro Val Cys Gln Pro Arg Cys 
    50                  55                  60                  


Lys His Gly Glu Cys Ile Gly Pro Asn Lys Cys Lys Cys His Pro Gly 
65                  70                  75                  80  


Tyr Ala Gly Lys Thr Cys Asn Gln Asp Glu His Ile Pro Ala Pro Leu 
                85                  90                  95      


Asp Gln Gly Ser Glu Gln Pro Leu Phe Gln Pro Leu Asp His Gln Ala 
            100                 105                 110         


Thr Ser Leu Pro Ser Arg Asp Leu Asn Glu Cys Gly Leu Lys Pro Arg 
        115                 120                 125             


Pro Cys Lys His Arg Cys Met Asn Thr Tyr Gly Ser Tyr Lys Cys Tyr 
    130                 135                 140                 


Cys Leu Asn Gly Tyr Met Leu Met Pro Asp Gly Ser Cys Ser Ser Ala 
145                 150                 155                 160 


Leu Thr Cys Ser Met Ala Asn Cys Gln Tyr Gly Cys Asp Val Val Lys 
                165                 170                 175     


Gly Gln Ile Arg Cys Gln Cys Pro Ser Pro Gly Leu Gln Leu Ala Pro 
            180                 185                 190         


Asp Gly Arg Thr Cys Val Asp Val Asp Glu Cys Ala Thr Gly Arg Ala 
        195                 200                 205             


Ser Cys Pro Arg Phe Arg Gln Cys Val Asn Thr Phe Gly Ser Tyr Ile 
    210                 215                 220                 


Cys Lys Cys His Lys Gly Phe Asp Leu Met Tyr Ile Gly Gly Lys Tyr 
225                 230                 235                 240 


Gln Cys His Asp Ile Asp Glu Cys Ser Leu Gly Gln Tyr Gln Cys Ser 
                245                 250                 255     


Ser Phe Ala Arg Cys Tyr Asn Ile Arg Gly Ser Tyr Lys Cys Lys Cys 
            260                 265                 270         


Lys Glu Gly Tyr Gln Gly Asp Gly Leu Thr Cys Val Tyr Ile Pro Lys 
        275                 280                 285             


Val Met Ile Glu Pro Ser Gly Pro Ile His Val Pro Lys Gly Asn Gly 
    290                 295                 300                 


Thr Ile Leu Lys Gly Asp Thr Gly Asn Asn Asn Trp Ile Pro Asp Val 
305                 310                 315                 320 


Gly Ser Thr Trp Trp Pro Pro Lys Thr Pro Tyr Ile Pro Pro Ile Ile 
                325                 330                 335     


Thr Asn Arg Pro Thr Ser Lys Pro Thr Thr Arg Pro Thr Pro Lys Pro 
            340                 345                 350         


Thr Pro Ile Pro Thr Pro Pro Pro Pro Pro Pro Leu Pro Thr Glu Leu 
        355                 360                 365             


Arg Thr Pro Leu Pro Pro Thr Thr Pro Glu Arg Pro Thr Thr Gly Leu 
    370                 375                 380                 


Thr Thr Ile Ala Pro Ala Ala Ser Thr Pro Pro Gly Gly Ile Thr Val 
385                 390                 395                 400 


Asp Asn Arg Val Gln Thr Asp Pro Gln Lys Pro Arg Gly Asp Val Phe 
                405                 410                 415     


Ser Val Leu Val His Ser Cys Asn Phe Asp His Gly Leu Cys Gly Trp 
            420                 425                 430         


Ile Arg Glu Lys Asp Asn Asp Leu His Trp Glu Pro Ile Arg Asp Pro 
        435                 440                 445             


Ala Gly Gly Gln Tyr Leu Thr Val Ser Ala Ala Lys Ala Pro Gly Gly 
    450                 455                 460                 


Lys Ala Ala Arg Leu Val Leu Pro Leu Gly Arg Leu Met His Ser Gly 
465                 470                 475                 480 


Asp Leu Cys Leu Ser Phe Arg His Lys Val Thr Gly Leu His Ser Gly 
                485                 490                 495     


Thr Leu Gln Val Phe Val Arg Lys His Gly Ala His Gly Ala Ala Leu 
            500                 505                 510         


Trp Gly Arg Asn Gly Gly His Gly Trp Arg Gln Thr Gln Ile Thr Leu 
        515                 520                 525             


Arg Gly Ala Asp Ile Lys Ser Val Val Phe Lys Gly Glu Lys Arg Arg 
    530                 535                 540                 


Gly His Thr Gly Glu Ile Gly Leu Asp Asp Val Ser Leu Lys Lys Gly 
545                 550                 555                 560 


His Cys Ser Glu Glu Arg 
                565     


<210>  9461
<211>  509
<212>  PRT
<213>  Homo Sapiens

<400>  9461

Met Asp Phe Leu Leu Ala Leu Val Leu Val Ser Ser Leu Tyr Leu Gln 
1               5                   10                  15      


Ala Ala Ala Glu Phe Asp Gly Arg Trp Pro Arg Gln Ile Val Ser Ser 
            20                  25                  30          


Ile Gly Leu Cys Arg Tyr Gly Gly Arg Ile Asp Cys Cys Trp Gly Trp 
        35                  40                  45              


Ala Arg Gln Ser Trp Gly Gln Cys Gln Pro Val Cys Gln Pro Arg Cys 
    50                  55                  60                  


Lys His Gly Glu Cys Ile Gly Pro Asn Lys Cys Lys Cys His Pro Gly 
65                  70                  75                  80  


Tyr Ala Gly Lys Thr Cys Asn Gln Asp Leu Asn Glu Cys Gly Leu Lys 
                85                  90                  95      


Pro Arg Pro Cys Lys His Arg Cys Met Asn Thr Tyr Gly Ser Tyr Lys 
            100                 105                 110         


Cys Tyr Cys Leu Asn Gly Tyr Met Leu Met Pro Asp Gly Ser Cys Ser 
        115                 120                 125             


Ser Ala Leu Thr Cys Ser Met Ala Asn Cys Gln Tyr Gly Cys Asp Val 
    130                 135                 140                 


Val Lys Gly Gln Ile Arg Cys Gln Cys Pro Ser Pro Gly Leu Gln Leu 
145                 150                 155                 160 


Ala Pro Asp Gly Arg Thr Cys Val Asp Val Asp Glu Cys Ala Thr Gly 
                165                 170                 175     


Arg Ala Ser Cys Pro Arg Phe Arg Gln Cys Val Asn Thr Phe Gly Ser 
            180                 185                 190         


Tyr Ile Cys Lys Cys His Lys Gly Phe Asp Leu Met Tyr Ile Gly Gly 
        195                 200                 205             


Lys Tyr Gln Cys His Asp Ile Asp Glu Cys Ser Leu Gly Gln Tyr Gln 
    210                 215                 220                 


Cys Ser Ser Phe Ala Arg Cys Tyr Asn Ile Arg Gly Ser Tyr Lys Cys 
225                 230                 235                 240 


Lys Cys Lys Glu Gly Tyr Gln Gly Asp Gly Leu Thr Cys Val Tyr Ile 
                245                 250                 255     


Pro Lys Val Met Ile Glu Pro Ser Gly Pro Ile His Val Pro Lys Gly 
            260                 265                 270         


Asn Gly Thr Ile Leu Lys Gly Asp Thr Gly Asn Asn Asn Trp Ile Pro 
        275                 280                 285             


Asp Val Gly Ser Thr Trp Trp Pro Pro Lys Thr Pro Tyr Ile Pro Pro 
    290                 295                 300                 


Ile Ile Thr Asn Arg Pro Thr Ser Lys Pro Thr Thr Arg Pro Thr Pro 
305                 310                 315                 320 


Lys Pro Thr Pro Ile Pro Thr Pro Pro Pro Pro Pro Pro Leu Pro Thr 
                325                 330                 335     


Glu Leu Arg Thr Pro Leu Pro Pro Thr Thr Pro Glu Arg Pro Thr Thr 
            340                 345                 350         


Gly Leu Thr Thr Ile Ala Pro Ala Ala Ser Thr Pro Pro Gly Gly Ile 
        355                 360                 365             


Thr Val Asp Asn Arg Val Gln Thr Asp Pro Gln Lys Pro Arg Gly Asp 
    370                 375                 380                 


Val Phe Ser Val Leu Val His Ser Cys Asn Phe Asp His Gly Leu Cys 
385                 390                 395                 400 


Gly Trp Ile Arg Glu Lys Asp Asn Asp Leu His Trp Glu Pro Ile Arg 
                405                 410                 415     


Asp Pro Ala Gly Gly Gln Tyr Leu Thr Val Ser Ala Ala Lys Ala Pro 
            420                 425                 430         


Gly Gly Lys Ala Ala Arg Leu Val Leu Pro Leu Gly Arg Leu Met His 
        435                 440                 445             


Ser Gly Asp Leu Cys Leu Ser Phe Arg His Lys Val Thr Gly Leu His 
    450                 455                 460                 


Ser Gly Thr Leu Gln Val Phe Val Arg Lys His Gly Ala His Gly Ala 
465                 470                 475                 480 


Ala Leu Trp Gly Arg Asn Gly Gly His Gly Trp Arg Gln Thr Gln Ile 
                485                 490                 495     


Thr Leu Arg Gly Ala Asp Ile Lys Ser Glu Ser Gln Arg 
            500                 505                 


<210>  9462
<211>  565
<212>  PRT
<213>  Homo Sapiens

<400>  9462

Met Asp Phe Leu Leu Ala Leu Val Leu Val Ser Ser Leu Tyr Leu Gln 
1               5                   10                  15      


Ala Ala Ala Glu Phe Asp Gly Arg Trp Pro Arg Gln Ile Val Ser Ser 
            20                  25                  30          


Ile Gly Leu Cys Arg Tyr Gly Gly Arg Ile Asp Cys Cys Trp Gly Trp 
        35                  40                  45              


Ala Arg Gln Ser Trp Gly Gln Cys Gln Pro Val Cys Gln Pro Arg Cys 
    50                  55                  60                  


Lys His Gly Glu Cys Ile Gly Pro Asn Lys Cys Lys Cys His Pro Gly 
65                  70                  75                  80  


Tyr Ala Gly Lys Thr Cys Asn Gln Asp Leu Asn Glu Cys Gly Leu Lys 
                85                  90                  95      


Pro Arg Pro Cys Lys His Arg Cys Met Asn Thr Tyr Gly Ser Tyr Lys 
            100                 105                 110         


Cys Tyr Cys Leu Asn Gly Tyr Met Leu Met Pro Asp Gly Ser Cys Ser 
        115                 120                 125             


Ser Ala Leu Thr Cys Ser Met Ala Asn Cys Gln Tyr Gly Cys Asp Val 
    130                 135                 140                 


Val Lys Gly Gln Ile Arg Cys Gln Cys Pro Ser Pro Gly Leu Gln Leu 
145                 150                 155                 160 


Ala Pro Asp Gly Arg Thr Cys Val Asp Val Asp Glu Cys Ala Thr Gly 
                165                 170                 175     


Arg Ala Ser Cys Pro Arg Phe Arg Gln Cys Val Asn Thr Phe Gly Ser 
            180                 185                 190         


Tyr Ile Cys Lys Cys His Lys Gly Phe Asp Leu Met Tyr Ile Gly Gly 
        195                 200                 205             


Lys Tyr Gln Cys His Asp Ile Asp Glu Cys Ser Leu Gly Gln Tyr Gln 
    210                 215                 220                 


Cys Ser Ser Phe Ala Arg Cys Tyr Asn Ile Arg Gly Ser Tyr Lys Cys 
225                 230                 235                 240 


Lys Cys Lys Glu Gly Tyr Gln Gly Asp Gly Leu Thr Cys Val Tyr Ile 
                245                 250                 255     


Pro Lys Val Met Ile Glu Pro Ser Gly Pro Ile His Val Pro Lys Gly 
            260                 265                 270         


Asn Gly Thr Ile Leu Lys Gly Asp Thr Gly Asn Asn Asn Trp Ile Pro 
        275                 280                 285             


Asp Val Gly Ser Thr Trp Trp Pro Pro Lys Thr Pro Tyr Ile Pro Pro 
    290                 295                 300                 


Ile Ile Thr Asn Arg Pro Thr Ser Lys Pro Thr Thr Arg Pro Thr Pro 
305                 310                 315                 320 


Lys Pro Thr Pro Ile Pro Thr Pro Pro Pro Pro Pro Pro Leu Pro Thr 
                325                 330                 335     


Glu Leu Arg Thr Pro Leu Pro Pro Thr Thr Pro Glu Arg Pro Thr Thr 
            340                 345                 350         


Gly Leu Thr Thr Ile Ala Pro Ala Ala Ser Thr Pro Pro Gly Gly Ile 
        355                 360                 365             


Thr Val Asp Asn Arg Val Gln Thr Asp Pro Gln Lys Pro Arg Gly Asp 
    370                 375                 380                 


Val Phe Ile Pro Arg Gln Pro Ser Asn Asp Leu Phe Glu Ile Phe Glu 
385                 390                 395                 400 


Ile Glu Arg Gly Val Ser Ala Asp Asp Glu Ala Lys Asp Asp Pro Gly 
                405                 410                 415     


Val Leu Val His Ser Cys Asn Phe Asp His Gly Leu Cys Gly Trp Ile 
            420                 425                 430         


Arg Glu Lys Asp Asn Asp Leu His Trp Glu Pro Ile Arg Asp Pro Ala 
        435                 440                 445             


Gly Gly Gln Tyr Leu Thr Val Ser Ala Ala Lys Ala Pro Gly Gly Lys 
    450                 455                 460                 


Ala Ala Arg Leu Val Leu Pro Leu Gly Arg Leu Met His Ser Gly Asp 
465                 470                 475                 480 


Leu Cys Leu Ser Phe Arg His Lys Val Thr Gly Leu His Ser Gly Thr 
                485                 490                 495     


Leu Gln Val Phe Val Arg Lys His Gly Ala His Gly Ala Ala Leu Trp 
            500                 505                 510         


Gly Arg Asn Gly Gly His Gly Trp Arg Gln Thr Gln Ile Thr Leu Arg 
        515                 520                 525             


Gly Ala Asp Ile Lys Ser Val Val Phe Lys Gly Glu Lys Arg Arg Gly 
    530                 535                 540                 


His Thr Gly Glu Ile Gly Leu Asp Asp Val Ser Leu Lys Lys Gly His 
545                 550                 555                 560 


Cys Ser Glu Glu Arg 
                565 


<210>  9463
<211>  536
<212>  PRT
<213>  Homo Sapiens

<400>  9463

Met Asp Phe Leu Leu Ala Leu Val Leu Val Ser Ser Leu Tyr Leu Gln 
1               5                   10                  15      


Ala Ala Ala Glu Phe Asp Gly Arg Trp Pro Arg Gln Ile Val Ser Ser 
            20                  25                  30          


Ile Gly Leu Cys Arg Tyr Gly Gly Arg Ile Asp Cys Cys Trp Gly Trp 
        35                  40                  45              


Ala Arg Gln Ser Trp Gly Gln Cys Gln Pro Val Cys Gln Pro Arg Cys 
    50                  55                  60                  


Lys His Gly Glu Cys Ile Gly Pro Asn Lys Cys Lys Cys His Pro Gly 
65                  70                  75                  80  


Tyr Ala Gly Lys Thr Cys Asn Gln Asp Leu Asn Glu Cys Gly Leu Lys 
                85                  90                  95      


Pro Arg Pro Cys Lys His Arg Cys Met Asn Thr Tyr Gly Ser Tyr Lys 
            100                 105                 110         


Cys Tyr Cys Leu Asn Gly Tyr Met Leu Met Pro Asp Gly Ser Cys Ser 
        115                 120                 125             


Ser Ala Leu Thr Cys Ser Met Ala Asn Cys Gln Tyr Gly Cys Asp Val 
    130                 135                 140                 


Val Lys Gly Gln Ile Arg Cys Gln Cys Pro Ser Pro Gly Leu Gln Leu 
145                 150                 155                 160 


Ala Pro Asp Gly Arg Thr Cys Val Asp Val Asp Glu Cys Ala Thr Gly 
                165                 170                 175     


Arg Ala Ser Cys Pro Arg Phe Arg Gln Cys Val Asn Thr Phe Gly Ser 
            180                 185                 190         


Tyr Ile Cys Lys Cys His Lys Gly Phe Asp Leu Met Tyr Ile Gly Gly 
        195                 200                 205             


Lys Tyr Gln Cys His Asp Ile Asp Glu Cys Ser Leu Gly Gln Tyr Gln 
    210                 215                 220                 


Cys Ser Ser Phe Ala Arg Cys Tyr Asn Ile Arg Gly Ser Tyr Lys Cys 
225                 230                 235                 240 


Lys Cys Lys Glu Gly Tyr Gln Gly Asp Gly Leu Thr Cys Val Tyr Ile 
                245                 250                 255     


Pro Lys Val Met Ile Glu Pro Ser Gly Pro Ile His Val Pro Lys Gly 
            260                 265                 270         


Asn Gly Thr Ile Leu Lys Gly Asp Thr Gly Asn Asn Asn Trp Ile Pro 
        275                 280                 285             


Asp Val Gly Ser Thr Trp Trp Pro Pro Lys Thr Pro Tyr Ile Pro Pro 
    290                 295                 300                 


Ile Ile Thr Asn Arg Pro Thr Ser Lys Pro Thr Thr Arg Pro Thr Pro 
305                 310                 315                 320 


Lys Pro Thr Pro Ile Pro Thr Pro Pro Pro Pro Pro Pro Leu Pro Thr 
                325                 330                 335     


Glu Leu Arg Thr Pro Leu Pro Pro Thr Thr Pro Glu Arg Pro Thr Thr 
            340                 345                 350         


Gly Leu Thr Thr Ile Ala Pro Ala Ala Ser Thr Pro Pro Gly Gly Ile 
        355                 360                 365             


Thr Val Asp Asn Arg Val Gln Thr Asp Pro Gln Lys Pro Arg Gly Asp 
    370                 375                 380                 


Val Phe Ser Val Leu Val His Ser Cys Asn Phe Asp His Gly Leu Cys 
385                 390                 395                 400 


Gly Trp Ile Arg Glu Lys Asp Asn Asp Leu His Trp Glu Pro Ile Arg 
                405                 410                 415     


Asp Pro Ala Gly Gly Gln Tyr Leu Thr Val Ser Ala Ala Lys Ala Pro 
            420                 425                 430         


Gly Gly Lys Ala Ala Arg Leu Val Leu Pro Leu Gly Arg Leu Met His 
        435                 440                 445             


Ser Gly Asp Leu Cys Leu Ser Phe Arg His Lys Val Thr Gly Leu His 
    450                 455                 460                 


Ser Gly Thr Leu Gln Val Phe Val Arg Lys His Gly Ala His Gly Ala 
465                 470                 475                 480 


Ala Leu Trp Gly Arg Asn Gly Gly His Gly Trp Arg Gln Thr Gln Ile 
                485                 490                 495     


Thr Leu Arg Gly Ala Asp Ile Lys Ser Val Val Phe Lys Gly Glu Lys 
            500                 505                 510         


Arg Arg Gly His Thr Gly Glu Ile Gly Leu Asp Asp Val Ser Leu Lys 
        515                 520                 525             


Lys Gly His Cys Ser Glu Glu Arg 
    530                 535     


<210>  9464
<211>  61
<212>  PRT
<213>  Homo Sapiens

<400>  9464

Met Asn Thr Tyr Gly Ser Tyr Lys Cys Tyr Cys Leu Asn Gly Tyr Met 
1               5                   10                  15      


Leu Met Pro Asp Gly Ser Cys Ser Ser Ala Leu Thr Cys Ser Met Ala 
            20                  25                  30          


Asn Cys Gln Tyr Gly Cys Asp Val Val Lys Gly Gln Ile Arg Cys Gln 
        35                  40                  45              


Cys Pro Ser Pro Gly Leu Gln Leu Ala Pro Asp Gly Arg 
    50                  55                  60      


<210>  9465
<211>  104
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9465

Xaa Gly Leu Cys Gly Trp Ile Arg Glu Lys Asp Asn Asp Leu His Trp 
1               5                   10                  15      


Glu Pro Ile Arg Asp Pro Ala Gly Ile Thr Lys Met Ile Lys Gly Leu 
            20                  25                  30          


Glu Lys Lys Ile Tyr Asp Gly Lys Leu Lys Glu Leu Gly Leu Leu Ser 
        35                  40                  45              


Leu Glu Lys Arg Arg Leu Arg Gly Lys Pro Leu Met Val Phe Lys Tyr 
    50                  55                  60                  


Met Lys Gly Trp His Arg Glu Gly Gly Asp Gln Leu Phe Ser Ile Cys 
65                  70                  75                  80  


Thr Lys Asn Arg Thr Arg Gly Asn Trp Leu Arg Leu Glu Tyr Lys Gly 
                85                  90                  95      


Ala Phe Leu Gly Arg Gly His Cys 
            100                 


<210>  9466
<211>  26
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9466

Xaa Asn Asp Leu His Trp Glu Pro Ile Arg Asp Pro Ala Asp Asn Cys 
1               5                   10                  15      


Ser Cys Leu His Ala Gly Gly Leu Asp Leu 
            20                  25      


<210>  9467
<211>  453
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9467

Xaa Trp Pro Arg Gln Ile Val Ser Ser Ile Gly Leu Cys Arg Tyr Gly 
1               5                   10                  15      


Gly Arg Ile Asp Cys Cys Trp Gly Trp Ala Arg Gln Ser Trp Gly Gln 
            20                  25                  30          


Cys Gln Pro Val Cys Gln Pro Arg Cys Lys His Gly Glu Cys Ile Gly 
        35                  40                  45              


Pro Asn Lys Cys Lys Cys His Pro Gly Tyr Ala Gly Lys Thr Cys Asn 
    50                  55                  60                  


Gln Asp Leu Asn Glu Cys Gly Leu Lys Pro Arg Pro Cys Lys His Arg 
65                  70                  75                  80  


Cys Met Asn Thr Tyr Gly Ser Tyr Lys Cys Tyr Cys Leu Asn Gly Tyr 
                85                  90                  95      


Met Leu Met Pro Asp Gly Ser Cys Ser Ser Ala Leu Thr Cys Ser Met 
            100                 105                 110         


Ala Asn Cys Gln Tyr Gly Cys Asp Val Val Lys Gly Gln Ile Arg Cys 
        115                 120                 125             


Gln Cys Pro Ser Pro Gly Leu Gln Leu Ala Pro Asp Gly Arg Thr Cys 
    130                 135                 140                 


Val Asp Val Asp Glu Cys Ala Thr Gly Arg Ala Ser Cys Pro Arg Phe 
145                 150                 155                 160 


Arg Gln Cys Val Asn Thr Phe Gly Ser Tyr Ile Cys Lys Cys His Lys 
                165                 170                 175     


Gly Phe Asp Leu Met Tyr Ile Gly Gly Lys Tyr Gln Cys His Asp Ile 
            180                 185                 190         


Asp Glu Cys Ser Leu Gly Gln Tyr Gln Cys Ser Ser Phe Ala Arg Cys 
        195                 200                 205             


Tyr Asn Ile Arg Gly Ser Tyr Lys Cys Lys Cys Lys Glu Gly Tyr Gln 
    210                 215                 220                 


Gly Asp Gly Leu Thr Cys Val Tyr Ile Pro Lys Val Met Ile Glu Pro 
225                 230                 235                 240 


Ser Gly Pro Ile His Val Pro Lys Gly Asn Gly Thr Ile Leu Lys Gly 
                245                 250                 255     


Asp Thr Gly Asn Asn Asn Trp Ile Pro Asp Val Gly Ser Thr Trp Trp 
            260                 265                 270         


Pro Pro Lys Thr Pro Tyr Ile Pro Pro Ile Ile Thr Asn Arg Pro Thr 
        275                 280                 285             


Ser Lys Pro Thr Thr Arg Pro Thr Pro Lys Pro Thr Pro Ile Pro Thr 
    290                 295                 300                 


Pro Pro Pro Pro Pro Pro Leu Pro Thr Glu Leu Arg Thr Pro Leu Pro 
305                 310                 315                 320 


Pro Thr Thr Pro Glu Arg Pro Thr Thr Gly Leu Thr Thr Ile Ala Pro 
                325                 330                 335     


Ala Ala Ser Thr Pro Pro Gly Gly Ile Thr Val Asp Asn Arg Val Gln 
            340                 345                 350         


Thr Asp Pro Gln Lys Pro Arg Gly Asp Val Phe Ile Pro Arg Gln Pro 
        355                 360                 365             


Ser Asn Asp Leu Phe Glu Ile Phe Glu Ile Glu Arg Gly Val Ser Ala 
    370                 375                 380                 


Asp Asp Glu Ala Lys Asp Asp Pro Gly Val Leu Val His Ser Cys Asn 
385                 390                 395                 400 


Phe Asp His Gly Leu Cys Gly Trp Ile Arg Glu Lys Asp Asn Asp Leu 
                405                 410                 415     


His Trp Glu Pro Ile Arg Asp Pro Ala Glu Ile Leu Gln Gly Thr Gln 
            420                 425                 430         


Phe Arg Glu Ile Phe Ile Gly Cys Ile Leu Ser Ala Ser Cys Val Thr 
        435                 440                 445             


Ser Tyr Leu Gly Cys 
    450             


<210>  9468
<211>  101
<212>  PRT
<213>  Homo Sapiens

<400>  9468

Met Pro Leu Glu Asp Glu Val Val Pro Pro Gln Val Leu Ser Glu Pro 
1               5                   10                  15      


Asn Glu Glu Ala Gly Ala Ala Leu Ser Pro Leu Pro Glu Val Pro Pro 
            20                  25                  30          


Trp Thr Gly Glu Val Ser Pro Ala Gln Arg Asp Gly Gly Ala Leu Gly 
        35                  40                  45              


Arg Gly Pro Trp Asp Ser Ser Asp Arg Ser Ala Leu Leu Lys Ser Lys 
    50                  55                  60                  


Leu Arg Ala Leu Leu Thr Ala Pro Arg Ser Leu Arg Arg Ser Ser Cys 
65                  70                  75                  80  


Phe Gly Gly Arg Met Asp Arg Ile Gly Ala Gln Ser Gly Leu Gly Cys 
                85                  90                  95      


Asn Ser Phe Arg Tyr 
            100     


<210>  9469
<211>  151
<212>  PRT
<213>  Homo Sapiens

<400>  9469

Met Ser Ser Phe Ser Thr Thr Thr Val Ser Phe Leu Leu Leu Leu Ala 
1               5                   10                  15      


Phe Gln Leu Leu Gly Gln Thr Arg Ala Asn Pro Met Tyr Asn Ala Val 
            20                  25                  30          


Ser Asn Ala Asp Leu Met Asp Phe Lys Asn Leu Leu Asp His Leu Glu 
        35                  40                  45              


Glu Lys Met Pro Leu Glu Asp Glu Val Val Pro Pro Gln Val Leu Ser 
    50                  55                  60                  


Glu Pro Asn Glu Glu Ala Gly Ala Ala Leu Ser Pro Leu Pro Glu Val 
65                  70                  75                  80  


Pro Pro Trp Thr Gly Glu Val Ser Pro Ala Gln Arg Asp Gly Gly Ala 
                85                  90                  95      


Leu Gly Arg Gly Pro Trp Asp Ser Ser Asp Arg Ser Ala Leu Leu Lys 
            100                 105                 110         


Ser Lys Leu Arg Ala Leu Leu Thr Ala Pro Arg Ser Leu Arg Arg Ser 
        115                 120                 125             


Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly Ala Gln Ser Gly Leu 
    130                 135                 140                 


Gly Cys Asn Ser Phe Arg Tyr 
145                 150     


<210>  9470
<211>  152
<212>  PRT
<213>  Homo Sapiens

<400>  9470

Met Ser Ser Phe Ser Thr Thr Thr Val Ser Phe Leu Leu Leu Leu Ala 
1               5                   10                  15      


Phe Gln Leu Leu Gly Gln Thr Arg Ala Asn Pro Met Tyr Asn Ala Val 
            20                  25                  30          


Ser Asn Ala Asp Leu Met Asp Phe Lys Asn Leu Leu Asp His Leu Glu 
        35                  40                  45              


Glu Lys Met Pro Leu Glu Asp Glu Val Val Pro Pro Gln Val Leu Ser 
    50                  55                  60                  


Glu Pro Asn Glu Glu Ala Gly Ala Ala Leu Ser Pro Leu Pro Glu Val 
65                  70                  75                  80  


Pro Pro Trp Thr Gly Glu Val Ser Pro Ala Gln Arg Asp Gly Gly Ala 
                85                  90                  95      


Leu Gly Arg Gly Pro Trp Asp Ser Ser Asp Arg Ser Ala Leu Leu Lys 
            100                 105                 110         


Ser Lys Leu Arg Ala Leu Leu Thr Ala Pro Arg Ser Leu Arg Arg Ser 
        115                 120                 125             


Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly Ala Gln Ser Gly Leu 
    130                 135                 140                 


Gly Cys Asn Ser Phe Arg Tyr Arg 
145                 150         


<210>  9471
<211>  134
<212>  PRT
<213>  Homo Sapiens

<400>  9471

Met Asp Pro Gln Thr Ala Pro Ser Arg Ala Leu Leu Leu Leu Leu Phe 
1               5                   10                  15      


Leu His Leu Ala Phe Leu Gly Gly Arg Ser His Pro Leu Gly Ser Pro 
            20                  25                  30          


Gly Ser Ala Ser Asp Leu Glu Thr Ser Gly Leu Gln Glu Gln Arg Asn 
        35                  40                  45              


His Leu Gln Gly Lys Leu Ser Glu Leu Gln Val Glu Gln Thr Ser Leu 
    50                  55                  60                  


Glu Pro Leu Gln Glu Ser Pro Arg Pro Thr Gly Val Trp Lys Ser Arg 
65                  70                  75                  80  


Glu Val Ala Thr Glu Gly Ile Arg Gly His Arg Lys Met Val Leu Tyr 
                85                  90                  95      


Thr Leu Arg Ala Pro Arg Ser Pro Lys Met Val Gln Gly Ser Gly Cys 
            100                 105                 110         


Phe Gly Arg Lys Met Asp Arg Ile Ser Ser Ser Ser Gly Leu Gly Cys 
        115                 120                 125             


Lys Val Leu Arg Arg His 
    130                 


<210>  9472
<211>  126
<212>  PRT
<213>  Homo Sapiens

<400>  9472

Met His Leu Ser Gln Leu Leu Ala Cys Ala Leu Leu Leu Thr Leu Leu 
1               5                   10                  15      


Ser Leu Arg Pro Ser Glu Ala Lys Pro Gly Ala Pro Pro Lys Val Pro 
            20                  25                  30          


Arg Thr Pro Pro Ala Glu Glu Leu Ala Glu Pro Gln Ala Ala Gly Gly 
        35                  40                  45              


Gly Gln Lys Lys Gly Asp Lys Ala Pro Gly Gly Gly Gly Ala Asn Leu 
    50                  55                  60                  


Lys Gly Asp Arg Ser Arg Leu Leu Arg Asp Leu Arg Val Asp Thr Lys 
65                  70                  75                  80  


Ser Arg Ala Ala Trp Ala Arg Leu Leu Gln Glu His Pro Asn Ala Arg 
                85                  90                  95      


Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly 
            100                 105                 110         


Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        115                 120                 125     


<210>  9473
<211>  126
<212>  PRT
<213>  Homo Sapiens

<400>  9473

Met His Leu Ser Gln Leu Leu Ala Cys Ala Leu Leu Leu Thr Leu Leu 
1               5                   10                  15      


Ser Leu Arg Pro Ser Glu Ala Lys Pro Gly Ala Pro Pro Lys Val Pro 
            20                  25                  30          


Arg Thr Pro Pro Ala Glu Glu Leu Ala Glu Pro Gln Ala Ala Gly Gly 
        35                  40                  45              


Gly Gln Lys Lys Gly Asp Lys Ala Pro Gly Gly Gly Gly Ala Asn Leu 
    50                  55                  60                  


Lys Gly Asp Arg Ser Arg Leu Leu Arg Asp Leu Arg Val Asp Thr Lys 
65                  70                  75                  80  


Ser Arg Ala Ala Trp Ala Arg Leu Leu Gln Glu His Pro Asn Ala Arg 
                85                  90                  95      


Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly 
            100                 105                 110         


Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        115                 120                 125     


<210>  9474
<211>  89
<212>  PRT
<213>  Homo Sapiens

<400>  9474

Met Ile Ser Ser Val Lys Leu Asn Leu Ile Leu Val Leu Ser Leu Ser 
1               5                   10                  15      


Thr Met His Val Phe Trp Cys Tyr Pro Val Pro Ser Ser Lys Val Ser 
            20                  25                  30          


Gly Lys Ser Asp Tyr Phe Leu Ile Leu Leu Asn Ser Cys Pro Thr Arg 
        35                  40                  45              


Leu Asp Arg Ser Lys Glu Leu Ala Phe Leu Lys Pro Ile Leu Glu Lys 
    50                  55                  60                  


Met Phe Val Lys Arg Ser Phe Arg Asn Gly Val Gly Thr Gly Met Lys 
65                  70                  75                  80  


Lys Thr Ser Phe Gln Arg Ala Lys Ser 
                85                  


<210>  9475
<211>  432
<212>  PRT
<213>  Homo Sapiens

<400>  9475

Met Pro Ala Gly Arg Ala Ala Arg Thr Cys Ala Leu Leu Ala Leu Cys 
1               5                   10                  15      


Leu Leu Gly Ala Gly Ala Gln Asp Phe Gly Pro Thr Arg Phe Ile Cys 
            20                  25                  30          


Thr Ser Val Pro Val Asp Ala Asp Met Cys Ala Ala Ser Val Ala Ala 
        35                  40                  45              


Gly Gly Ala Glu Glu Leu Arg Ser Ser Val Leu Gln Leu Arg Glu Thr 
    50                  55                  60                  


Val Leu Gln Gln Lys Glu Thr Ile Leu Ser Gln Lys Glu Thr Ile Arg 
65                  70                  75                  80  


Glu Leu Thr Ala Lys Leu Gly Arg Cys Glu Ser Gln Ser Thr Leu Asp 
                85                  90                  95      


Pro Gly Ala Gly Glu Ala Arg Ala Gly Gly Gly Arg Lys Gln Pro Gly 
            100                 105                 110         


Ser Gly Lys Asn Thr Met Gly Asp Leu Ser Arg Thr Pro Ala Ala Glu 
        115                 120                 125             


Thr Leu Ser Gln Leu Gly Gln Thr Leu Gln Ser Leu Lys Thr Arg Leu 
    130                 135                 140                 


Glu Asn Leu Glu Gln Tyr Ser Arg Leu Asn Ser Ser Ser Gln Thr Asn 
145                 150                 155                 160 


Ser Leu Lys Asp Leu Leu Gln Ser Lys Ile Asp Glu Leu Glu Arg Gln 
                165                 170                 175     


Val Leu Ser Arg Val Asn Thr Leu Glu Glu Gly Lys Gly Gly Pro Arg 
            180                 185                 190         


Asn Asp Thr Glu Glu Arg Val Lys Ile Glu Thr Ala Leu Thr Ser Leu 
        195                 200                 205             


His Gln Arg Ile Ser Glu Leu Glu Lys Gly Gln Lys Asp Asn Arg Pro 
    210                 215                 220                 


Gly Asp Lys Phe Gln Leu Thr Phe Pro Leu Arg Thr Asn Tyr Met Tyr 
225                 230                 235                 240 


Ala Lys Val Lys Lys Ser Leu Pro Glu Met Tyr Ala Phe Thr Val Cys 
                245                 250                 255     


Met Trp Leu Lys Ser Ser Ala Thr Pro Gly Val Gly Thr Pro Phe Ser 
            260                 265                 270         


Tyr Ala Val Pro Gly Gln Ala Asn Glu Leu Val Leu Ile Glu Trp Gly 
        275                 280                 285             


Asn Asn Pro Met Glu Ile Leu Ile Asn Asp Lys Val Ala Lys Leu Pro 
    290                 295                 300                 


Phe Val Ile Asn Asp Gly Lys Trp His His Ile Cys Val Thr Trp Thr 
305                 310                 315                 320 


Thr Arg Asp Gly Val Trp Glu Ala Tyr Gln Asp Gly Thr Gln Gly Gly 
                325                 330                 335     


Ser Gly Glu Asn Leu Ala Pro Tyr His Pro Ile Lys Pro Gln Gly Val 
            340                 345                 350         


Leu Val Leu Gly Gln Glu Gln Asp Thr Leu Gly Gly Gly Phe Asp Ala 
        355                 360                 365             


Thr Gln Ala Phe Val Gly Glu Leu Ala His Phe Asn Ile Trp Asp Arg 
    370                 375                 380                 


Lys Leu Thr Pro Gly Glu Val Tyr Asn Leu Ala Thr Cys Ser Thr Lys 
385                 390                 395                 400 


Ala Leu Ser Gly Asn Val Ile Ala Trp Ala Glu Ser His Ile Glu Ile 
                405                 410                 415     


Tyr Gly Gly Ala Thr Lys Trp Thr Phe Glu Ala Cys Arg Gln Ile Asn 
            420                 425                 430         


<210>  9476
<211>  431
<212>  PRT
<213>  Homo Sapiens

<400>  9476

Met Leu Ala Leu Leu Ala Ala Ser Val Ala Leu Ala Val Ala Ala Gly 
1               5                   10                  15      


Ala Gln Asp Ser Pro Ala Pro Gly Ser Arg Phe Val Cys Thr Ala Leu 
            20                  25                  30          


Pro Pro Glu Ala Val His Ala Gly Cys Pro Leu Pro Ala Met Pro Met 
        35                  40                  45              


Gln Gly Gly Ala Gln Ser Pro Glu Glu Glu Leu Arg Ala Ala Val Leu 
    50                  55                  60                  


Gln Leu Arg Glu Thr Val Val Gln Gln Lys Glu Thr Leu Gly Ala Gln 
65                  70                  75                  80  


Arg Glu Ala Ile Arg Glu Leu Thr Gly Lys Leu Ala Arg Cys Glu Gly 
                85                  90                  95      


Leu Ala Gly Gly Lys Ala Arg Gly Ala Gly Ala Thr Gly Lys Asp Thr 
            100                 105                 110         


Met Gly Asp Leu Pro Arg Asp Pro Gly His Val Val Glu Gln Leu Ser 
        115                 120                 125             


Arg Ser Leu Gln Thr Leu Lys Asp Arg Leu Glu Ser Leu Glu His Gln 
    130                 135                 140                 


Leu Arg Ala Asn Val Ser Asn Ala Gly Leu Pro Gly Asp Phe Arg Glu 
145                 150                 155                 160 


Val Leu Gln Gln Arg Leu Gly Glu Leu Glu Arg Gln Leu Leu Arg Lys 
                165                 170                 175     


Val Ala Glu Leu Glu Asp Glu Lys Ser Leu Leu His Asn Glu Thr Ser 
            180                 185                 190         


Ala His Arg Gln Lys Thr Glu Ser Thr Leu Asn Ala Leu Leu Gln Arg 
        195                 200                 205             


Val Thr Glu Leu Glu Arg Gly Asn Ser Ala Phe Lys Ser Pro Asp Ala 
    210                 215                 220                 


Phe Lys Val Ser Leu Pro Leu Arg Thr Asn Tyr Leu Tyr Gly Lys Ile 
225                 230                 235                 240 


Lys Lys Thr Leu Pro Glu Leu Tyr Ala Phe Thr Ile Cys Leu Trp Leu 
                245                 250                 255     


Arg Ser Ser Ala Ser Pro Gly Ile Gly Thr Pro Phe Ser Tyr Ala Val 
            260                 265                 270         


Pro Gly Gln Ala Asn Glu Ile Val Leu Ile Glu Trp Gly Asn Asn Pro 
        275                 280                 285             


Ile Glu Leu Leu Ile Asn Asp Lys Val Ala Gln Leu Pro Leu Phe Val 
    290                 295                 300                 


Ser Asp Gly Lys Trp His His Ile Cys Val Thr Trp Thr Thr Arg Asp 
305                 310                 315                 320 


Gly Met Trp Glu Ala Phe Gln Asp Gly Glu Lys Leu Gly Thr Gly Glu 
                325                 330                 335     


Asn Leu Ala Pro Trp His Pro Ile Lys Pro Gly Gly Val Leu Ile Leu 
            340                 345                 350         


Gly Gln Glu Gln Asp Thr Val Gly Gly Arg Phe Asp Ala Thr Gln Ala 
        355                 360                 365             


Phe Val Gly Glu Leu Ser Gln Phe Asn Ile Trp Asp Arg Val Leu Arg 
    370                 375                 380                 


Ala Gln Glu Ile Val Asn Ile Ala Asn Cys Ser Thr Asn Met Pro Gly 
385                 390                 395                 400 


Asn Ile Ile Pro Trp Val Asp Asn Asn Val Asp Val Phe Gly Gly Ala 
                405                 410                 415     


Ser Lys Trp Pro Val Glu Thr Cys Glu Glu Arg Leu Leu Asp Leu 
            420                 425                 430     


<210>  9477
<211>  500
<212>  PRT
<213>  Homo Sapiens

<400>  9477

Leu Lys Phe Leu Ala Val Leu Leu Ala Ala Gly Met Leu Ala Phe Leu 
1               5                   10                  15      


Gly Ala Val Ile Cys Ile Ile Ala Ser Val Pro Leu Ala Ala Ser Pro 
            20                  25                  30          


Ala Arg Ala Leu Pro Gly Gly Ala Asp Asn Ala Ser Val Ala Ser Gly 
        35                  40                  45              


Ala Ala Ala Ser Pro Gly Pro Gln Arg Ser Leu Ser Ala Leu His Gly 
    50                  55                  60                  


Ala Gly Gly Ser Ala Gly Pro Pro Ala Leu Pro Gly Ala Pro Ala Ala 
65                  70                  75                  80  


Ser Ala His Pro Leu Pro Pro Gly Pro Leu Phe Ser Arg Phe Leu Cys 
                85                  90                  95      


Thr Pro Leu Ala Ala Ala Cys Pro Ser Gly Ala Gln Gln Gly Asp Ala 
            100                 105                 110         


Ala Gly Ala Ala Pro Gly Glu Arg Glu Glu Leu Leu Leu Leu Gln Ser 
        115                 120                 125             


Thr Ala Glu Gln Leu Arg Gln Thr Ala Leu Gln Gln Glu Ala Arg Ile 
    130                 135                 140                 


Arg Ala Asp Gln Asp Thr Ile Arg Glu Leu Thr Gly Lys Leu Gly Arg 
145                 150                 155                 160 


Cys Glu Ser Gly Leu Pro Arg Gly Leu Gln Gly Ala Gly Pro Arg Arg 
                165                 170                 175     


Asp Thr Met Ala Asp Gly Pro Trp Asp Ser Pro Ala Leu Ile Leu Glu 
            180                 185                 190         


Leu Glu Asp Ala Val Arg Ala Leu Arg Asp Arg Ile Asp Arg Leu Glu 
        195                 200                 205             


Gln Glu Leu Pro Ala Arg Val Asn Leu Ser Ala Ala Pro Ala Pro Val 
    210                 215                 220                 


Ser Ala Val Pro Thr Gly Leu His Ser Lys Met Asp Gln Leu Glu Gly 
225                 230                 235                 240 


Gln Leu Leu Ala Gln Val Leu Ala Leu Glu Lys Glu Arg Val Ala Leu 
                245                 250                 255     


Ser His Ser Ser Arg Arg Gln Arg Gln Glu Val Glu Lys Glu Leu Asp 
            260                 265                 270         


Val Leu Gln Gly Arg Val Ala Glu Leu Glu His Gly Ser Ser Ala Tyr 
        275                 280                 285             


Ser Pro Pro Asp Ala Phe Lys Ile Ser Ile Pro Ile Arg Asn Asn Tyr 
    290                 295                 300                 


Met Tyr Ala Arg Val Arg Lys Ala Leu Pro Glu Leu Tyr Ala Phe Thr 
305                 310                 315                 320 


Ala Cys Met Trp Leu Arg Ser Arg Ser Ser Gly Thr Gly Gln Gly Thr 
                325                 330                 335     


Pro Phe Ser Tyr Ser Val Pro Gly Gln Ala Asn Glu Ile Val Leu Leu 
            340                 345                 350         


Glu Ala Gly His Glu Pro Met Glu Leu Leu Ile Asn Asp Lys Val Ala 
        355                 360                 365             


Gln Leu Pro Leu Ser Leu Lys Asp Asn Gly Trp His His Ile Cys Ile 
    370                 375                 380                 


Ala Trp Thr Thr Arg Asp Gly Leu Trp Ser Ala Tyr Gln Asp Gly Glu 
385                 390                 395                 400 


Leu Gln Gly Ser Gly Glu Asn Leu Ala Ala Trp His Pro Ile Lys Pro 
                405                 410                 415     


His Gly Ile Leu Ile Leu Gly Gln Glu Gln Asp Thr Leu Gly Gly Arg 
            420                 425                 430         


Phe Asp Ala Thr Gln Ala Phe Val Gly Asp Ile Ala Gln Phe Asn Leu 
        435                 440                 445             


Trp Asp His Ala Leu Thr Pro Ala Gln Val Leu Gly Ile Ala Asn Cys 
    450                 455                 460                 


Thr Ala Pro Leu Leu Gly Asn Val Leu Pro Trp Glu Asp Lys Leu Val 
465                 470                 475                 480 


Glu Ala Phe Gly Gly Ala Thr Lys Ala Ala Phe Asp Val Cys Lys Gly 
                485                 490                 495     


Arg Ala Lys Ala 
            500 


<210>  9478
<211>  500
<212>  PRT
<213>  Homo Sapiens

<400>  9478

Leu Lys Phe Leu Ala Val Leu Leu Ala Ala Gly Met Leu Ala Phe Leu 
1               5                   10                  15      


Gly Ala Val Ile Cys Ile Ile Ala Ser Val Pro Leu Ala Ala Ser Pro 
            20                  25                  30          


Ala Arg Ala Leu Pro Gly Gly Ala Asp Asn Ala Ser Val Ala Ser Gly 
        35                  40                  45              


Ala Ala Ala Ser Pro Gly Pro Gln Arg Ser Leu Ser Ala Leu His Gly 
    50                  55                  60                  


Ala Gly Gly Ser Ala Gly Pro Pro Ala Leu Pro Gly Ala Pro Ala Ala 
65                  70                  75                  80  


Ser Ala His Pro Leu Pro Pro Gly Pro Leu Phe Ser Arg Phe Leu Cys 
                85                  90                  95      


Thr Pro Leu Ala Ala Ala Cys Pro Ser Gly Ala Gln Gln Gly Asp Ala 
            100                 105                 110         


Ala Gly Ala Ala Pro Gly Glu Arg Glu Glu Leu Leu Leu Leu Gln Ser 
        115                 120                 125             


Thr Ala Glu Gln Leu Arg Gln Thr Ala Leu Gln Gln Glu Ala Arg Ile 
    130                 135                 140                 


Arg Ala Asp Gln Asp Thr Ile Arg Glu Leu Thr Gly Lys Leu Gly Arg 
145                 150                 155                 160 


Cys Glu Ser Gly Leu Pro Arg Gly Leu Gln Gly Ala Gly Pro Arg Arg 
                165                 170                 175     


Asp Thr Met Ala Asp Gly Pro Trp Asp Ser Pro Ala Leu Ile Leu Glu 
            180                 185                 190         


Leu Glu Asp Ala Val Arg Ala Leu Arg Asp Arg Ile Asp Arg Leu Glu 
        195                 200                 205             


Gln Glu Leu Pro Ala Arg Val Asn Leu Ser Ala Ala Pro Ala Pro Val 
    210                 215                 220                 


Ser Ala Val Pro Thr Gly Leu His Ser Lys Met Asp Gln Leu Glu Gly 
225                 230                 235                 240 


Gln Leu Leu Ala Gln Val Leu Ala Leu Glu Lys Glu Arg Val Ala Leu 
                245                 250                 255     


Ser His Ser Ser Arg Arg Gln Arg Gln Glu Val Glu Lys Glu Leu Asp 
            260                 265                 270         


Val Leu Gln Gly Arg Val Ala Glu Leu Glu His Gly Ser Ser Ala Tyr 
        275                 280                 285             


Ser Pro Pro Asp Ala Phe Lys Ile Ser Ile Pro Ile Arg Asn Asn Tyr 
    290                 295                 300                 


Met Tyr Ala Arg Val Arg Lys Ala Leu Pro Glu Leu Tyr Ala Phe Thr 
305                 310                 315                 320 


Ala Cys Met Trp Leu Arg Ser Arg Ser Ser Gly Thr Gly Gln Gly Thr 
                325                 330                 335     


Pro Phe Ser Tyr Ser Val Pro Gly Gln Ala Asn Glu Ile Val Leu Leu 
            340                 345                 350         


Glu Ala Gly His Glu Pro Met Glu Leu Leu Ile Asn Asp Lys Val Ala 
        355                 360                 365             


Gln Leu Pro Leu Ser Leu Lys Asp Asn Gly Trp His His Ile Cys Ile 
    370                 375                 380                 


Ala Trp Thr Thr Arg Asp Gly Leu Trp Ser Ala Tyr Gln Asp Gly Glu 
385                 390                 395                 400 


Leu Gln Gly Ser Gly Glu Asn Leu Ala Ala Trp His Pro Ile Lys Pro 
                405                 410                 415     


His Gly Ile Leu Ile Leu Gly Gln Glu Gln Asp Thr Leu Gly Gly Arg 
            420                 425                 430         


Phe Asp Ala Thr Gln Ala Phe Val Gly Asp Ile Ala Gln Phe Asn Leu 
        435                 440                 445             


Trp Asp His Ala Leu Thr Pro Ala Gln Val Leu Gly Ile Ala Asn Cys 
    450                 455                 460                 


Thr Ala Pro Leu Leu Gly Asn Val Leu Pro Trp Glu Asp Lys Leu Val 
465                 470                 475                 480 


Glu Ala Phe Gly Gly Ala Thr Lys Ala Ala Phe Asp Val Cys Lys Gly 
                485                 490                 495     


Arg Ala Lys Ala 
            500 


<210>  9479
<211>  196
<212>  PRT
<213>  Homo Sapiens

<400>  9479

Met Glu Ile Ile Ser Ser Lys Leu Phe Ile Leu Leu Thr Leu Ala Thr 
1               5                   10                  15      


Ser Ser Leu Leu Thr Ser Asn Ile Phe Cys Ala Asp Glu Leu Val Met 
            20                  25                  30          


Ser Asn Leu His Ser Lys Glu Asn Tyr Asp Lys Tyr Ser Glu Pro Arg 
        35                  40                  45              


Gly Tyr Pro Lys Gly Glu Arg Ser Leu Asn Phe Glu Glu Leu Lys Asp 
    50                  55                  60                  


Trp Gly Pro Lys Asn Val Ile Lys Met Ser Thr Pro Ala Val Asn Lys 
65                  70                  75                  80  


Met Pro His Ser Phe Ala Asn Leu Pro Leu Arg Phe Gly Arg Asn Val 
                85                  90                  95      


Gln Glu Glu Arg Ser Ala Gly Ala Thr Ala Asn Leu Pro Leu Arg Ser 
            100                 105                 110         


Gly Arg Asn Met Glu Val Ser Leu Val Arg Arg Val Pro Asn Leu Pro 
        115                 120                 125             


Gln Arg Phe Gly Arg Thr Thr Thr Ala Lys Ser Val Cys Arg Met Leu 
    130                 135                 140                 


Ser Asp Leu Cys Gln Gly Ser Met His Ser Pro Cys Ala Asn Asp Leu 
145                 150                 155                 160 


Phe Tyr Ser Met Thr Cys Gln His Gln Glu Ile Gln Asn Pro Asp Gln 
                165                 170                 175     


Lys Gln Ser Arg Arg Leu Leu Phe Lys Lys Ile Asp Asp Ala Glu Leu 
            180                 185                 190         


Lys Gln Glu Lys 
        195     


<210>  9480
<211>  165
<212>  PRT
<213>  Homo Sapiens

<400>  9480

Leu Ala Trp Arg Pro Gly Glu Arg Gly Ala Pro Ala Ser Arg Pro Arg 
1               5                   10                  15      


Leu Ala Leu Leu Leu Leu Leu Leu Leu Leu Pro Leu Pro Ser Gly Ala 
            20                  25                  30          


Trp Tyr Lys His Val Ala Ser Pro Arg Tyr His Thr Val Gly Arg Ala 
        35                  40                  45              


Ala Gly Leu Leu Met Gly Leu Arg Arg Ser Pro Tyr Leu Trp Arg Arg 
    50                  55                  60                  


Ala Leu Arg Ala Ala Ala Gly Pro Leu Ala Arg Asp Thr Leu Ser Pro 
65                  70                  75                  80  


Glu Pro Ala Ala Arg Glu Ala Pro Leu Leu Leu Pro Ser Trp Val Gln 
                85                  90                  95      


Glu Leu Trp Glu Thr Arg Arg Arg Ser Ser Gln Ala Gly Ile Pro Val 
            100                 105                 110         


Arg Ala Pro Arg Ser Pro Arg Ala Pro Glu Pro Ala Leu Glu Pro Glu 
        115                 120                 125             


Ser Leu Asp Phe Ser Gly Ala Gly Gln Arg Leu Arg Arg Asp Val Ser 
    130                 135                 140                 


Arg Pro Ala Val Asp Pro Ala Ala Asn Arg Leu Gly Leu Pro Cys Leu 
145                 150                 155                 160 


Ala Pro Gly Pro Phe 
                165 


<210>  9481
<211>  113
<212>  PRT
<213>  Homo Sapiens

<400>  9481

Met Gly Leu Arg Arg Ser Pro Tyr Leu Trp Arg Arg Ala Leu Arg Ala 
1               5                   10                  15      


Ala Ala Gly Pro Leu Ala Arg Asp Thr Leu Ser Pro Glu Pro Ala Ala 
            20                  25                  30          


Arg Glu Ala Pro Leu Leu Leu Pro Ser Trp Val Gln Glu Leu Trp Glu 
        35                  40                  45              


Thr Arg Arg Arg Ser Ser Gln Ala Gly Ile Pro Val Arg Ala Pro Arg 
    50                  55                  60                  


Ser Pro Arg Ala Pro Glu Pro Ala Leu Glu Pro Glu Ser Leu Asp Phe 
65                  70                  75                  80  


Ser Gly Ala Gly Gln Arg Leu Arg Arg Asp Val Ser Arg Pro Ala Val 
                85                  90                  95      


Asp Pro Ala Ala Asn Arg Leu Gly Leu Pro Cys Leu Ala Pro Gly Pro 
            100                 105                 110         


Phe 
    


<210>  9482
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  9482

Met Ser Arg Pro Leu Glu Gly Pro Arg Gly His Ala Ala Ser Pro Gly 
1               5                   10                  15      


Leu Leu Trp Ala Thr Arg Val Thr Ser Thr Leu Ala Gly Leu His Glu 
            20                  25                  30          


Leu Ala Leu Ser Asp Glu Thr Arg His Asn Trp Phe Ala Ser Gln Met 
        35                  40                  45              


Asn Lys Gly Ser Cys Leu Ser Pro Ala Arg Leu Leu Ser Cys Cys Pro 
    50                  55                  60                  


Arg Gly Phe Arg Ser Cys Gly Arg Arg Asp Ala Gly Ala Pro Arg Gln 
65                  70                  75                  80  


Gly Ser Pro Ser Val Arg Pro Gly Ala Arg Ala Pro Gln Ser Leu Arg 
                85                  90                  95      


Trp Asn Arg Ser Pro Trp Thr Ser Ala Glu Leu Ala Arg Asp Phe Gly 
            100                 105                 110         


Glu Thr Ser Pro Ala Gln Arg Trp Thr Pro Gln Gln Thr Ala Leu Ala 
        115                 120                 125             


<210>  9483
<211>  97
<212>  PRT
<213>  Homo Sapiens

<400>  9483

Met Leu Gly Asn Lys Arg Leu Gly Leu Ser Gly Leu Thr Leu Ala Leu 
1               5                   10                  15      


Ser Leu Leu Val Cys Leu Gly Ala Leu Ala Glu Ala Tyr Pro Ser Lys 
            20                  25                  30          


Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu Asp Met Ala Arg Tyr 
        35                  40                  45              


Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr Arg Gln Arg Tyr 
    50                  55                  60                  


Gly Lys Arg Ser Ser Pro Glu Thr Leu Ile Ser Asp Leu Leu Met Arg 
65                  70                  75                  80  


Glu Ser Thr Glu Asn Val Pro Arg Thr Arg Leu Glu Asp Pro Ala Met 
                85                  90                  95      


Trp 
    


<210>  9484
<211>  97
<212>  PRT
<213>  Homo Sapiens

<400>  9484

Met Leu Gly Asn Lys Arg Leu Gly Leu Ser Gly Leu Thr Leu Ala Leu 
1               5                   10                  15      


Ser Leu Leu Val Cys Leu Gly Ala Leu Ala Glu Ala Tyr Pro Ser Lys 
            20                  25                  30          


Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu Asp Met Ala Arg Tyr 
        35                  40                  45              


Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr Arg Gln Arg Tyr 
    50                  55                  60                  


Gly Lys Arg Ser Ser Pro Glu Thr Leu Ile Ser Asp Leu Leu Met Arg 
65                  70                  75                  80  


Glu Ser Thr Glu Asn Val Pro Arg Thr Arg Leu Glu Asp Pro Ala Met 
                85                  90                  95      


Trp 
    


<210>  9485
<211>  97
<212>  PRT
<213>  Homo Sapiens

<400>  9485

Met Leu Gly Asn Lys Arg Leu Gly Leu Ser Gly Leu Thr Leu Ala Leu 
1               5                   10                  15      


Ser Leu Leu Val Cys Leu Gly Ala Leu Ala Glu Ala Tyr Pro Ser Lys 
            20                  25                  30          


Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu Asp Met Ala Arg Tyr 
        35                  40                  45              


Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr Arg Gln Arg Tyr 
    50                  55                  60                  


Gly Lys Arg Ser Ser Pro Glu Thr Leu Ile Ser Asp Leu Leu Met Arg 
65                  70                  75                  80  


Glu Ser Thr Glu Asn Val Pro Arg Thr Arg Leu Glu Asp Pro Ala Met 
                85                  90                  95      


Trp 
    


<210>  9486
<211>  35
<212>  PRT
<213>  Homo Sapiens

<400>  9486

Met Ala Glu Phe Arg Phe Leu Lys Ser Gly Ala Leu Pro Ile Leu Ser 
1               5                   10                  15      


Leu Leu Cys Leu Gln Ala Leu Lys Phe Ser Leu Gly Cys Ser Arg Gly 
            20                  25                  30          


Ser Ser Glu 
        35  


<210>  9487
<211>  63
<212>  PRT
<213>  Homo Sapiens

<400>  9487

Met Ala Gly Lys Lys Val Leu Ile Val Tyr Ala His Gln Glu Pro Lys 
1               5                   10                  15      


Ser Phe Asn Gly Ser Leu Lys Asn Val Ala Val Asp Glu Leu Ser Arg 
            20                  25                  30          


Gln Gly Cys Thr Val Thr Val Ser Asp Leu Tyr Ala Met Asn Leu Glu 
        35                  40                  45              


Pro Arg Ala Thr Asp Lys Asp Ile Thr Gly Thr Leu Ser Asn Pro 
    50                  55                  60              


<210>  9488
<211>  139
<212>  PRT
<213>  Homo Sapiens

<400>  9488

Met Ala Gly Lys Lys Val Leu Ile Val Tyr Ala His Gln Glu Pro Lys 
1               5                   10                  15      


Ser Phe Asn Gly Ser Leu Lys Asn Val Ala Val Asp Glu Leu Ser Arg 
            20                  25                  30          


Gln Gly Cys Thr Val Thr Val Ser Asp Leu Tyr Ala Met Asn Leu Glu 
        35                  40                  45              


Pro Arg Ala Thr Asp Lys Asp Ile Thr Gly Thr Leu Ser Asn Pro Glu 
    50                  55                  60                  


Val Phe Asn Tyr Gly Val Glu Thr His Glu Ala Tyr Lys Gln Arg Ser 
65                  70                  75                  80  


Leu Ala Ser Asp Ile Thr Asp Glu Gln Lys Lys Val Arg Glu Ala Asp 
                85                  90                  95      


Leu Val Ile Phe Gln Phe Pro Leu Tyr Trp Phe Ser Val Pro Ala Ile 
            100                 105                 110         


Leu Lys Gly Trp Met Asp Arg Val Leu Cys Gln Gly Phe Ala Phe Asp 
        115                 120                 125             


Ile Pro Gly Phe Tyr Asp Ser Gly Leu Leu Gln 
    130                 135                 


<210>  9489
<211>  139
<212>  PRT
<213>  Homo Sapiens

<400>  9489

Met Ala Gly Lys Lys Val Leu Ile Val Tyr Ala His Gln Glu Pro Lys 
1               5                   10                  15      


Ser Phe Asn Gly Ser Leu Lys Asn Val Ala Val Asp Glu Leu Ser Arg 
            20                  25                  30          


Gln Gly Cys Thr Val Thr Val Ser Asp Leu Tyr Ala Met Asn Leu Glu 
        35                  40                  45              


Pro Arg Ala Thr Asp Lys Asp Ile Thr Gly Thr Leu Ser Asn Pro Glu 
    50                  55                  60                  


Val Phe Asn Tyr Gly Val Glu Thr His Glu Ala Tyr Lys Gln Arg Ser 
65                  70                  75                  80  


Leu Ala Ser Asp Ile Thr Asp Glu Gln Lys Lys Val Arg Glu Ala Asp 
                85                  90                  95      


Leu Val Ile Phe Gln Phe Pro Leu Tyr Trp Phe Ser Val Pro Ala Ile 
            100                 105                 110         


Leu Lys Gly Trp Met Asp Arg Val Leu Cys Gln Gly Phe Ala Phe Asp 
        115                 120                 125             


Ile Pro Gly Phe Tyr Asp Ser Gly Leu Leu Gln 
    130                 135                 


<210>  9490
<211>  231
<212>  PRT
<213>  Homo Sapiens

<400>  9490

Met Ala Gly Lys Lys Val Leu Ile Val Tyr Ala His Gln Glu Pro Lys 
1               5                   10                  15      


Ser Phe Asn Gly Ser Leu Lys Asn Val Ala Val Asp Glu Leu Ser Arg 
            20                  25                  30          


Gln Gly Cys Thr Val Thr Val Ser Asp Leu Tyr Ala Met Asn Leu Glu 
        35                  40                  45              


Pro Arg Ala Thr Asp Lys Asp Ile Thr Gly Thr Leu Ser Asn Pro Glu 
    50                  55                  60                  


Val Phe Asn Tyr Gly Val Glu Thr His Glu Ala Tyr Lys Gln Arg Ser 
65                  70                  75                  80  


Leu Ala Ser Asp Ile Thr Asp Glu Gln Lys Lys Val Arg Glu Ala Asp 
                85                  90                  95      


Leu Val Ile Phe Gln Phe Pro Leu Tyr Trp Phe Ser Val Pro Ala Ile 
            100                 105                 110         


Leu Lys Gly Trp Met Asp Arg Val Leu Cys Gln Gly Phe Ala Phe Asp 
        115                 120                 125             


Ile Pro Gly Phe Tyr Asp Ser Gly Leu Leu Gln Gly Lys Leu Ala Leu 
    130                 135                 140                 


Leu Ser Val Thr Thr Gly Gly Thr Ala Glu Met Tyr Thr Lys Thr Gly 
145                 150                 155                 160 


Val Asn Gly Asp Ser Arg Tyr Phe Leu Trp Pro Leu Gln His Gly Thr 
                165                 170                 175     


Leu His Phe Cys Gly Phe Lys Val Leu Ala Pro Gln Ile Ser Phe Ala 
            180                 185                 190         


Pro Glu Ile Ala Ser Glu Glu Glu Arg Lys Gly Met Val Ala Ala Trp 
        195                 200                 205             


Ser Gln Arg Leu Gln Thr Ile Trp Lys Glu Glu Pro Ile Pro Cys Thr 
    210                 215                 220                 


Ala His Trp His Phe Gly Gln 
225                 230     


<210>  9491
<211>  231
<212>  PRT
<213>  Homo Sapiens

<400>  9491

Met Ala Gly Lys Lys Val Leu Ile Val Tyr Ala His Gln Glu Pro Lys 
1               5                   10                  15      


Ser Phe Asn Gly Ser Leu Lys Asn Val Ala Val Asp Glu Leu Ser Arg 
            20                  25                  30          


Gln Gly Cys Thr Val Thr Val Ser Asp Leu Tyr Ala Met Asn Leu Glu 
        35                  40                  45              


Pro Arg Ala Thr Asp Lys Asp Ile Thr Gly Thr Leu Ser Asn Pro Glu 
    50                  55                  60                  


Val Phe Asn Tyr Gly Val Glu Thr His Glu Ala Tyr Lys Gln Arg Ser 
65                  70                  75                  80  


Leu Ala Ser Asp Ile Thr Asp Glu Gln Lys Lys Val Arg Glu Ala Asp 
                85                  90                  95      


Leu Val Ile Phe Gln Phe Pro Leu Tyr Trp Phe Ser Val Pro Ala Ile 
            100                 105                 110         


Leu Lys Gly Trp Met Asp Arg Val Leu Cys Gln Gly Phe Ala Phe Asp 
        115                 120                 125             


Ile Pro Gly Phe Tyr Asp Ser Gly Leu Leu Gln Gly Lys Leu Ala Leu 
    130                 135                 140                 


Leu Ser Val Thr Thr Gly Gly Thr Ala Glu Met Tyr Thr Lys Thr Gly 
145                 150                 155                 160 


Val Asn Gly Asp Ser Arg Tyr Phe Leu Trp Pro Leu Gln His Gly Thr 
                165                 170                 175     


Leu His Phe Cys Gly Phe Lys Val Leu Ala Pro Gln Ile Ser Phe Ala 
            180                 185                 190         


Pro Glu Ile Ala Ser Glu Glu Glu Arg Lys Gly Met Val Ala Ala Trp 
        195                 200                 205             


Ser Gln Arg Leu Gln Thr Ile Trp Lys Glu Glu Pro Ile Pro Cys Thr 
    210                 215                 220                 


Ala His Trp His Phe Gly Gln 
225                 230     


<210>  9492
<211>  231
<212>  PRT
<213>  Homo Sapiens

<400>  9492

Met Ala Gly Lys Lys Val Leu Ile Val Tyr Ala His Gln Glu Pro Lys 
1               5                   10                  15      


Ser Phe Asn Gly Ser Leu Lys Asn Val Ala Val Asp Glu Leu Ser Arg 
            20                  25                  30          


Gln Gly Cys Thr Val Thr Val Ser Asp Leu Tyr Ala Met Asn Leu Glu 
        35                  40                  45              


Pro Arg Ala Thr Asp Lys Asp Ile Thr Gly Thr Leu Ser Asn Pro Glu 
    50                  55                  60                  


Val Phe Asn Tyr Gly Val Glu Thr His Glu Ala Tyr Lys Gln Arg Ser 
65                  70                  75                  80  


Leu Ala Ser Asp Ile Thr Asp Glu Gln Lys Lys Val Arg Glu Ala Asp 
                85                  90                  95      


Leu Val Ile Phe Gln Phe Pro Leu Tyr Trp Phe Ser Val Pro Ala Ile 
            100                 105                 110         


Leu Lys Gly Trp Met Asp Arg Val Leu Cys Gln Gly Phe Ala Phe Asp 
        115                 120                 125             


Ile Pro Gly Phe Tyr Asp Ser Gly Leu Leu Gln Gly Lys Leu Ala Leu 
    130                 135                 140                 


Leu Ser Val Thr Thr Gly Gly Thr Ala Glu Met Tyr Thr Lys Thr Gly 
145                 150                 155                 160 


Val Asn Gly Asp Ser Arg Tyr Phe Leu Trp Pro Leu Gln His Gly Thr 
                165                 170                 175     


Leu His Phe Cys Gly Phe Lys Val Leu Ala Pro Gln Ile Ser Phe Ala 
            180                 185                 190         


Pro Glu Ile Ala Ser Glu Glu Glu Arg Lys Gly Met Val Ala Ala Trp 
        195                 200                 205             


Ser Gln Arg Leu Gln Thr Ile Trp Lys Glu Glu Pro Ile Pro Cys Thr 
    210                 215                 220                 


Ala His Trp His Phe Gly Gln 
225                 230     


<210>  9493
<211>  193
<212>  PRT
<213>  Homo Sapiens

<400>  9493

Met Ala Gly Lys Lys Val Leu Ile Val Tyr Ala His Gln Glu Pro Lys 
1               5                   10                  15      


Ser Phe Asn Gly Ser Leu Lys Asn Val Ala Val Asp Glu Leu Ser Arg 
            20                  25                  30          


Gln Gly Cys Thr Val Thr Val Ser Asp Leu Tyr Ala Met Asn Leu Glu 
        35                  40                  45              


Pro Arg Ala Thr Asp Lys Asp Ile Thr Gly Thr Leu Ser Asn Pro Glu 
    50                  55                  60                  


Val Phe Asn Tyr Gly Val Glu Thr His Glu Ala Tyr Lys Gln Arg Ser 
65                  70                  75                  80  


Leu Ala Ser Asp Ile Thr Asp Glu Gln Lys Lys Val Arg Glu Ala Asp 
                85                  90                  95      


Leu Val Ile Phe Gln Gly Lys Leu Ala Leu Leu Ser Val Thr Thr Gly 
            100                 105                 110         


Gly Thr Ala Glu Met Tyr Thr Lys Thr Gly Val Asn Gly Asp Ser Arg 
        115                 120                 125             


Tyr Phe Leu Trp Pro Leu Gln His Gly Thr Leu His Phe Cys Gly Phe 
    130                 135                 140                 


Lys Val Leu Ala Pro Gln Ile Ser Phe Ala Pro Glu Ile Ala Ser Glu 
145                 150                 155                 160 


Glu Glu Arg Lys Gly Met Val Ala Ala Trp Ser Gln Arg Leu Gln Thr 
                165                 170                 175     


Ile Trp Lys Glu Glu Pro Ile Pro Cys Thr Ala His Trp His Phe Gly 
            180                 185                 190         


Gln 
    


<210>  9494
<211>  193
<212>  PRT
<213>  Homo Sapiens

<400>  9494

Met Ala Gly Lys Lys Val Leu Ile Val Tyr Ala His Gln Glu Pro Lys 
1               5                   10                  15      


Ser Phe Asn Gly Ser Leu Lys Asn Val Ala Val Asp Glu Leu Ser Arg 
            20                  25                  30          


Gln Gly Cys Thr Val Thr Val Ser Asp Leu Tyr Ala Met Asn Leu Glu 
        35                  40                  45              


Pro Arg Ala Thr Asp Lys Asp Ile Thr Gly Thr Leu Ser Asn Pro Glu 
    50                  55                  60                  


Val Phe Asn Tyr Gly Val Glu Thr His Glu Ala Tyr Lys Gln Arg Ser 
65                  70                  75                  80  


Leu Ala Ser Asp Ile Thr Asp Glu Gln Lys Lys Val Arg Glu Ala Asp 
                85                  90                  95      


Leu Val Ile Phe Gln Gly Lys Leu Ala Leu Leu Ser Val Thr Thr Gly 
            100                 105                 110         


Gly Thr Ala Glu Met Tyr Thr Lys Thr Gly Val Asn Gly Asp Ser Arg 
        115                 120                 125             


Tyr Phe Leu Trp Pro Leu Gln His Gly Thr Leu His Phe Cys Gly Phe 
    130                 135                 140                 


Lys Val Leu Ala Pro Gln Ile Ser Phe Ala Pro Glu Ile Ala Ser Glu 
145                 150                 155                 160 


Glu Glu Arg Lys Gly Met Val Ala Ala Trp Ser Gln Arg Leu Gln Thr 
                165                 170                 175     


Ile Trp Lys Glu Glu Pro Ile Pro Cys Thr Ala His Trp His Phe Gly 
            180                 185                 190         


Gln 
    


<210>  9495
<211>  1299
<212>  PRT
<213>  Homo Sapiens

<400>  9495

Met Pro Lys Lys Lys Arg Leu Ser Ala Gly Arg Val Pro Leu Ile Leu 
1               5                   10                  15      


Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val Pro Leu Asp Pro Lys 
            20                  25                  30          


Leu Leu Glu Asp Leu Val Gln Pro Pro Thr Ile Thr Gln Gln Ser Pro 
        35                  40                  45              


Lys Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile Val Ile Gln Cys Glu 
    50                  55                  60                  


Ala Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp Thr Arg Asn Gly Thr 
65                  70                  75                  80  


His Phe Asp Ile Asp Lys Asp Pro Leu Val Thr Met Lys Pro Gly Thr 
                85                  90                  95      


Gly Thr Leu Ile Ile Asn Ile Met Ser Glu Gly Lys Ala Glu Thr Tyr 
            100                 105                 110         


Glu Gly Val Tyr Gln Cys Thr Ala Arg Asn Glu Arg Gly Ala Ala Val 
        115                 120                 125             


Ser Asn Asn Ile Val Val Arg Pro Ser Arg Ser Pro Leu Trp Thr Lys 
    130                 135                 140                 


Glu Lys Leu Glu Pro Ile Thr Leu Gln Ser Gly Gln Ser Leu Val Leu 
145                 150                 155                 160 


Pro Cys Arg Pro Pro Ile Gly Leu Pro Pro Pro Ile Ile Phe Trp Met 
                165                 170                 175     


Asp Asn Ser Phe Gln Arg Leu Pro Gln Ser Glu Arg Val Ser Gln Gly 
            180                 185                 190         


Leu Asn Gly Asp Leu Tyr Phe Ser Asn Val Leu Pro Glu Asp Thr Arg 
        195                 200                 205             


Glu Asp Tyr Ile Cys Tyr Ala Arg Phe Asn His Thr Gln Thr Ile Gln 
    210                 215                 220                 


Gln Lys Gln Pro Ile Ser Val Lys Val Ile Ser Val Asp Glu Leu Asn 
225                 230                 235                 240 


Asp Thr Ile Ala Ala Asn Leu Ser Asp Thr Glu Phe Tyr Gly Ala Lys 
                245                 250                 255     


Ser Ser Arg Glu Arg Pro Pro Thr Phe Leu Thr Pro Glu Gly Asn Ala 
            260                 265                 270         


Ser Asn Lys Glu Glu Leu Arg Gly Asn Val Leu Ser Leu Glu Cys Ile 
        275                 280                 285             


Ala Glu Gly Leu Pro Thr Pro Ile Ile Tyr Trp Ala Lys Glu Asp Gly 
    290                 295                 300                 


Met Leu Pro Lys Asn Arg Thr Val Tyr Lys Asn Phe Glu Lys Thr Leu 
305                 310                 315                 320 


Gln Ile Ile His Val Ser Glu Ala Asp Ser Gly Asn Tyr Gln Cys Ile 
                325                 330                 335     


Ala Lys Asn Ala Leu Gly Ala Ile His His Thr Ile Ser Val Arg Val 
            340                 345                 350         


Lys Ala Ala Pro Tyr Trp Ile Thr Ala Pro Gln Asn Leu Val Leu Ser 
        355                 360                 365             


Pro Gly Glu Asp Gly Thr Leu Ile Cys Arg Ala Asn Gly Asn Pro Lys 
    370                 375                 380                 


Pro Arg Ile Ser Trp Leu Thr Asn Gly Val Pro Ile Glu Ile Ala Pro 
385                 390                 395                 400 


Asp Asp Pro Ser Arg Lys Ile Asp Gly Asp Thr Ile Ile Phe Ser Asn 
                405                 410                 415     


Val Gln Glu Arg Ser Ser Ala Val Tyr Gln Cys Asn Ala Ser Asn Glu 
            420                 425                 430         


Tyr Gly Tyr Leu Leu Ala Asn Ala Phe Val Asn Val Leu Ala Glu Pro 
        435                 440                 445             


Pro Arg Ile Leu Thr Pro Ala Asn Thr Leu Tyr Gln Val Ile Ala Asn 
    450                 455                 460                 


Arg Pro Ala Leu Leu Asp Cys Ala Phe Phe Gly Ser Pro Leu Pro Thr 
465                 470                 475                 480 


Ile Glu Trp Phe Lys Gly Ala Lys Gly Ser Ala Leu His Glu Asp Ile 
                485                 490                 495     


Tyr Val Leu His Glu Asn Gly Thr Leu Glu Ile Pro Val Ala Gln Lys 
            500                 505                 510         


Asp Ser Thr Gly Thr Tyr Thr Cys Val Ala Arg Asn Lys Leu Gly Met 
        515                 520                 525             


Ala Lys Asn Glu Val His Leu Glu Ile Lys Asp Pro Thr Trp Ile Val 
    530                 535                 540                 


Lys Gln Pro Glu Tyr Ala Val Val Gln Arg Gly Ser Met Val Ser Phe 
545                 550                 555                 560 


Glu Cys Lys Val Lys His Asp His Thr Leu Ser Leu Thr Val Leu Trp 
                565                 570                 575     


Leu Lys Asp Asn Arg Glu Leu Pro Ser Asp Glu Arg Phe Thr Val Asp 
            580                 585                 590         


Lys Asp His Leu Val Val Ala Asp Val Ser Asp Asp Asp Ser Gly Thr 
        595                 600                 605             


Tyr Thr Cys Val Ala Asn Thr Thr Leu Asp Ser Val Ser Ala Ser Ala 
    610                 615                 620                 


Val Leu Ser Val Val Ala Pro Thr Pro Thr Pro Ala Pro Val Tyr Asp 
625                 630                 635                 640 


Val Pro Asn Pro Pro Phe Asp Leu Glu Leu Thr Asp Gln Leu Asp Lys 
                645                 650                 655     


Ser Val Gln Leu Ser Trp Thr Pro Gly Asp Asp Asn Asn Ser Pro Ile 
            660                 665                 670         


Thr Arg Ile His His Glu Tyr Glu Asp Ala Met His Lys Pro Gly Leu 
        675                 680                 685             


Trp His His Gln Thr Glu Val Ser Gly Thr Gln Thr Thr Ala Gln Leu 
    690                 695                 700                 


Lys Leu Ser Pro Tyr Val Asn Tyr Ser Phe Arg Val Met Ala Val Asn 
705                 710                 715                 720 


Ser Ile Gly Lys Ser Leu Pro Ser Glu Ala Ser Glu Gln Tyr Leu Thr 
                725                 730                 735     


Lys Ala Ser Glu Pro Asp Lys Asn Pro Thr Ala Val Glu Gly Leu Gly 
            740                 745                 750         


Ser Glu Pro Asp Asn Leu Val Ile Thr Trp Lys Pro Leu Asn Gly Phe 
        755                 760                 765             


Glu Ser Asn Gly Pro Gly Leu Gln Tyr Lys Val Ser Trp Arg Gln Lys 
    770                 775                 780                 


Asp Gly Asp Asp Glu Trp Thr Ser Val Val Val Ala Asn Val Ser Lys 
785                 790                 795                 800 


Tyr Ile Val Ser Gly Thr Pro Thr Phe Val Pro Tyr Leu Ile Lys Val 
                805                 810                 815     


Gln Ala Leu Asn Asp Met Gly Phe Ala Pro Glu Pro Ala Val Val Met 
            820                 825                 830         


Gly His Ser Gly Glu Asp Leu Pro Met Val Ala Pro Gly Asn Val Arg 
        835                 840                 845             


Val Asn Val Val Asn Ser Thr Leu Ala Glu Val His Trp Asp Pro Val 
    850                 855                 860                 


Pro Leu Lys Ser Ile Arg Gly His Leu Gln Gly Tyr Arg Ile Tyr Tyr 
865                 870                 875                 880 


Trp Lys Thr Gln Ser Ser Ser Lys Arg Asn Arg Arg His Ile Glu Lys 
                885                 890                 895     


Lys Ile Leu Thr Phe Gln Gly Ser Lys Thr His Gly Met Leu Pro Gly 
            900                 905                 910         


Leu Glu Pro Phe Ser His Tyr Thr Leu Asn Val Arg Val Val Asn Gly 
        915                 920                 925             


Lys Gly Glu Gly Pro Ala Ser Pro Asp Arg Val Phe Asn Thr Pro Glu 
    930                 935                 940                 


Gly Val Pro Ser Ala Pro Ser Ser Leu Lys Ile Val Asn Pro Thr Leu 
945                 950                 955                 960 


Asp Ser Leu Thr Leu Glu Trp Asp Pro Pro Ser His Pro Asn Gly Ile 
                965                 970                 975     


Leu Thr Glu Tyr Thr Leu Lys Tyr Gln Pro Ile Asn Ser Thr His Glu 
            980                 985                 990         


Leu Gly Pro Leu Val Asp Leu Lys  Ile Pro Ala Asn Lys  Thr Arg Trp 
        995                 1000                 1005             


Thr Leu  Lys Asn Leu Asn Phe  Ser Thr Arg Tyr Lys  Phe Tyr Phe 
    1010                 1015                 1020             


Tyr Ala  Gln Thr Ser Ala Gly  Ser Gly Ser Gln Ile  Thr Glu Glu 
    1025                 1030                 1035             


Ala Val  Thr Thr Val Asp Glu  Ala Gly Ile Leu Pro  Pro Asp Val 
    1040                 1045                 1050             


Gly Ala  Gly Lys Val Gln Ala  Val Asn Pro Arg Ile  Ser Asn Leu 
    1055                 1060                 1065             


Thr Ala  Ala Ala Ala Glu Thr  Tyr Ala Asn Ile Ser  Trp Glu Tyr 
    1070                 1075                 1080             


Glu Gly  Pro Glu His Val Asn  Phe Tyr Val Glu Tyr  Gly Val Ala 
    1085                 1090                 1095             


Gly Ser  Lys Glu Glu Trp Arg  Lys Glu Ile Val Asn  Gly Ser Arg 
    1100                 1105                 1110             


Ser Phe  Phe Gly Leu Lys Gly  Leu Met Pro Gly Thr  Ala Tyr Lys 
    1115                 1120                 1125             


Val Arg  Val Gly Ala Val Gly  Asp Ser Gly Phe Val  Ser Ser Glu 
    1130                 1135                 1140             


Asp Val  Phe Glu Thr Gly Pro  Ala Met Ala Ser Arg  Gln Val Asp 
    1145                 1150                 1155             


Ile Ala  Thr Gln Gly Trp Phe  Ile Gly Leu Met Cys  Ala Val Ala 
    1160                 1165                 1170             


Leu Leu  Ile Leu Ile Leu Leu  Ile Val Cys Phe Ile  Arg Arg Asn 
    1175                 1180                 1185             


Lys Gly  Gly Lys Tyr Pro Val  Lys Glu Lys Glu Asp  Ala His Ala 
    1190                 1195                 1200             


Asp Pro  Glu Ile Gln Pro Met  Lys Glu Asp Asp Gly  Thr Phe Gly 
    1205                 1210                 1215             


Glu Tyr  Ser Asp Ala Glu Asp  His Lys Pro Leu Lys  Lys Gly Ser 
    1220                 1225                 1230             


Arg Thr  Pro Ser Asp Arg Thr  Val Lys Lys Glu Asp  Ser Asp Asp 
    1235                 1240                 1245             


Ser Leu  Val Asp Tyr Gly Glu  Gly Val Asn Gly Gln  Phe Asn Glu 
    1250                 1255                 1260             


Asp Gly  Ser Phe Ile Gly Gln  Tyr Ser Gly Lys Lys  Glu Lys Glu 
    1265                 1270                 1275             


Pro Ala  Glu Gly Asn Glu Ser  Ser Glu Ala Pro Ser  Pro Val Asn 
    1280                 1285                 1290             


Ala Met  Asn Ser Phe Val 
    1295                 


<210>  9496
<211>  106
<212>  PRT
<213>  Homo Sapiens

<400>  9496

Met Gln Leu Lys Ile Met Pro Lys Lys Lys Arg Leu Ser Ala Gly Arg 
1               5                   10                  15      


Val Pro Leu Ile Leu Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val 
            20                  25                  30          


Pro Leu Asp Leu Val Gln Pro Pro Thr Ile Thr Gln Gln Ser Pro Lys 
        35                  40                  45              


Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile Val Ile Gln Cys Glu Ala 
    50                  55                  60                  


Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp Thr Arg Asn Gly Thr His 
65                  70                  75                  80  


Phe Asp Ile Asp Lys Asp Pro Leu Val Thr Met Lys Pro Gly Thr Gly 
                85                  90                  95      


Thr Leu Ile Ile Asn Ile Met Ser Glu Gly 
            100                 105     


<210>  9497
<211>  106
<212>  PRT
<213>  Homo Sapiens

<400>  9497

Met Gln Leu Lys Ile Met Pro Lys Lys Lys Arg Leu Ser Ala Gly Arg 
1               5                   10                  15      


Val Pro Leu Ile Leu Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val 
            20                  25                  30          


Pro Leu Asp Leu Val Gln Pro Pro Thr Ile Thr Gln Gln Ser Pro Lys 
        35                  40                  45              


Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile Val Ile Gln Cys Glu Ala 
    50                  55                  60                  


Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp Thr Arg Asn Gly Thr His 
65                  70                  75                  80  


Phe Asp Ile Asp Lys Asp Pro Leu Val Thr Met Lys Pro Gly Thr Gly 
                85                  90                  95      


Thr Leu Ile Ile Asn Ile Met Ser Glu Gly 
            100                 105     


<210>  9498
<211>  1183
<212>  PRT
<213>  Homo Sapiens

<400>  9498

Met Gln Leu Lys Ile Met Pro Lys Lys Lys Arg Leu Ser Ala Gly Arg 
1               5                   10                  15      


Val Pro Leu Ile Leu Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val 
            20                  25                  30          


Pro Leu Asp Leu Val Gln Pro Pro Thr Ile Thr Gln Gln Ser Pro Lys 
        35                  40                  45              


Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile Val Ile Gln Cys Glu Ala 
    50                  55                  60                  


Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp Thr Arg Asn Gly Thr His 
65                  70                  75                  80  


Phe Asp Ile Asp Lys Asp Pro Leu Val Thr Met Lys Pro Gly Thr Gly 
                85                  90                  95      


Thr Leu Ile Ile Asn Ile Met Ser Glu Gly Lys Ala Glu Thr Tyr Glu 
            100                 105                 110         


Gly Val Tyr Gln Cys Thr Ala Arg Asn Glu Arg Gly Ala Ala Val Ser 
        115                 120                 125             


Asn Asn Ile Val Val Arg Pro Ser Arg Ser Pro Leu Trp Thr Lys Glu 
    130                 135                 140                 


Lys Leu Glu Pro Ile Thr Leu Gln Ser Gly Gln Ser Leu Val Leu Pro 
145                 150                 155                 160 


Cys Arg Pro Pro Ile Gly Leu Pro Pro Pro Ile Ile Phe Trp Met Asp 
                165                 170                 175     


Asn Ser Phe Gln Arg Leu Pro Gln Ser Glu Arg Val Ser Gln Gly Leu 
            180                 185                 190         


Asn Gly Asp Leu Tyr Phe Ser Asn Val Leu Pro Glu Asp Thr Arg Glu 
        195                 200                 205             


Asp Tyr Ile Cys Tyr Ala Arg Phe Asn His Thr Gln Thr Ile Gln Gln 
    210                 215                 220                 


Lys Gln Pro Ile Ser Val Lys Val Ile Ser Val Asp Glu Leu Asn Asp 
225                 230                 235                 240 


Thr Ile Ala Ala Asn Leu Ser Asp Thr Glu Phe Tyr Gly Ala Lys Ser 
                245                 250                 255     


Ser Arg Glu Arg Pro Pro Thr Phe Leu Thr Pro Glu Gly Asn Ala Ser 
            260                 265                 270         


Asn Lys Glu Glu Leu Arg Gly Asn Val Leu Ser Leu Glu Cys Ile Ala 
        275                 280                 285             


Glu Gly Leu Pro Thr Pro Ile Ile Tyr Trp Ala Lys Glu Asp Gly Met 
    290                 295                 300                 


Leu Pro Lys Asn Arg Thr Val Tyr Lys Asn Phe Glu Lys Thr Leu Gln 
305                 310                 315                 320 


Ile Ile His Val Ser Glu Ala Asp Ser Gly Asn Tyr Gln Cys Ile Ala 
                325                 330                 335     


Lys Asn Ala Leu Gly Ala Ile His His Thr Ile Ser Val Arg Val Lys 
            340                 345                 350         


Ala Ala Pro Tyr Trp Ile Thr Ala Pro Gln Asn Leu Val Leu Ser Pro 
        355                 360                 365             


Gly Glu Asp Gly Thr Leu Ile Cys Arg Ala Asn Gly Asn Pro Lys Pro 
    370                 375                 380                 


Arg Ile Ser Trp Leu Thr Asn Gly Val Pro Ile Glu Ile Ala Pro Asp 
385                 390                 395                 400 


Asp Pro Ser Arg Lys Ile Asp Gly Asp Thr Ile Ile Phe Ser Asn Val 
                405                 410                 415     


Gln Glu Arg Ser Ser Ala Val Tyr Gln Cys Asn Ala Ser Asn Glu Tyr 
            420                 425                 430         


Gly Tyr Leu Leu Ala Asn Ala Phe Val Asn Val Leu Ala Glu Pro Pro 
        435                 440                 445             


Arg Ile Leu Thr Pro Ala Asn Thr Leu Tyr Gln Val Ile Ala Asn Arg 
    450                 455                 460                 


Pro Ala Leu Leu Asp Cys Ala Phe Phe Gly Ser Pro Leu Pro Thr Ile 
465                 470                 475                 480 


Glu Trp Phe Lys Gly Ala Lys Gly Ser Ala Leu His Glu Asp Ile Tyr 
                485                 490                 495     


Val Leu His Glu Asn Gly Thr Leu Glu Ile Pro Val Ala Gln Lys Asp 
            500                 505                 510         


Ser Thr Gly Thr Tyr Thr Cys Val Ala Arg Asn Lys Leu Gly Met Ala 
        515                 520                 525             


Lys Asn Glu Val His Leu Glu Ile Lys Asp Pro Thr Trp Ile Val Lys 
    530                 535                 540                 


Gln Pro Glu Tyr Ala Val Val Gln Arg Gly Ser Met Val Ser Phe Glu 
545                 550                 555                 560 


Cys Lys Val Lys His Asp His Thr Leu Ser Leu Thr Val Leu Trp Leu 
                565                 570                 575     


Lys Asp Asn Arg Glu Leu Pro Ser Asp Glu Arg Phe Thr Val Asp Lys 
            580                 585                 590         


Asp His Leu Val Val Ala Asp Val Ser Asp Asp Asp Ser Gly Thr Tyr 
        595                 600                 605             


Thr Cys Val Ala Asn Thr Thr Leu Asp Ser Val Ser Ala Ser Ala Val 
    610                 615                 620                 


Leu Ser Val Val Asp Val Pro Asn Pro Pro Phe Asp Leu Glu Leu Thr 
625                 630                 635                 640 


Asp Gln Leu Asp Lys Ser Val Gln Leu Ser Trp Thr Pro Gly Asp Asp 
                645                 650                 655     


Asn Asn Ser Pro Ile Thr Lys Phe Ile Ile Glu Tyr Glu Asp Ala Met 
            660                 665                 670         


His Lys Pro Gly Leu Trp His His Gln Thr Glu Val Ser Gly Thr Gln 
        675                 680                 685             


Thr Thr Ala Gln Leu Lys Leu Ser Pro Tyr Val Asn Tyr Ser Phe Arg 
    690                 695                 700                 


Val Met Ala Val Asn Ser Ile Gly Lys Ser Leu Pro Ser Glu Ala Ser 
705                 710                 715                 720 


Glu Gln Tyr Leu Thr Lys Ala Ser Glu Pro Asp Lys Asn Pro Thr Ala 
                725                 730                 735     


Val Glu Gly Leu Gly Ser Glu Pro Asp Asn Leu Val Ile Thr Trp Lys 
            740                 745                 750         


Pro Leu Asn Gly Phe Glu Ser Asn Gly Pro Gly Leu Gln Tyr Lys Val 
        755                 760                 765             


Ser Trp Arg Gln Lys Asp Gly Asp Asp Glu Trp Thr Ser Val Val Val 
    770                 775                 780                 


Ala Asn Val Ser Lys Tyr Ile Val Ser Gly Thr Pro Thr Phe Val Pro 
785                 790                 795                 800 


Tyr Leu Ile Lys Val Gln Ala Leu Asn Asp Met Gly Phe Ala Pro Glu 
                805                 810                 815     


Pro Ala Val Val Met Gly His Ser Gly Glu Asp Leu Pro Met Val Ala 
            820                 825                 830         


Pro Gly Asn Val Arg Val Asn Val Val Asn Ser Thr Leu Ala Glu Val 
        835                 840                 845             


His Trp Asp Pro Val Pro Leu Lys Ser Ile Arg Gly His Leu Gln Gly 
    850                 855                 860                 


Tyr Arg Ile Tyr Tyr Trp Lys Thr Gln Ser Ser Ser Lys Arg Asn Arg 
865                 870                 875                 880 


Arg His Ile Glu Lys Lys Ile Leu Thr Phe Gln Gly Ser Lys Thr His 
                885                 890                 895     


Gly Met Leu Pro Gly Leu Glu Pro Phe Ser His Tyr Thr Leu Asn Val 
            900                 905                 910         


Arg Val Val Asn Gly Lys Gly Glu Gly Pro Ala Ser Pro Asp Arg Val 
        915                 920                 925             


Phe Asn Thr Pro Glu Gly Val Pro Ser Ala Pro Ser Ser Leu Lys Ile 
    930                 935                 940                 


Val Asn Pro Thr Leu Asp Ser Leu Thr Leu Glu Trp Asp Pro Pro Ser 
945                 950                 955                 960 


His Pro Asn Gly Ile Leu Thr Glu Tyr Thr Leu Lys Tyr Gln Pro Ile 
                965                 970                 975     


Asn Ser Thr His Glu Leu Gly Pro Leu Val Asp Leu Lys Ile Pro Ala 
            980                 985                 990         


Asn Lys Thr Arg Trp Thr Leu Lys  Asn Leu Asn Phe Ser  Thr Arg Tyr 
        995                 1000                 1005             


Lys Phe  Tyr Phe Tyr Ala Gln  Thr Ser Ala Gly Ser  Gly Ser Gln 
    1010                 1015                 1020             


Ile Thr  Glu Glu Ala Val Thr  Thr Val Asp Glu Ala  Met Ala Ser 
    1025                 1030                 1035             


Arg Gln  Val Asp Ile Ala Thr  Gln Gly Trp Phe Ile  Gly Leu Met 
    1040                 1045                 1050             


Cys Ala  Val Ala Leu Leu Ile  Leu Ile Leu Leu Ile  Val Cys Phe 
    1055                 1060                 1065             


Ile Arg  Arg Asn Lys Gly Gly  Lys Tyr Pro Val Lys  Glu Lys Glu 
    1070                 1075                 1080             


Asp Ala  His Ala Asp Pro Glu  Ile Gln Pro Met Lys  Glu Asp Asp 
    1085                 1090                 1095             


Gly Thr  Phe Gly Glu Tyr Ser  Asp Ala Glu Asp His  Lys Pro Leu 
    1100                 1105                 1110             


Lys Lys  Gly Ser Arg Thr Pro  Ser Asp Arg Thr Val  Lys Lys Glu 
    1115                 1120                 1125             


Asp Ser  Asp Asp Ser Leu Val  Asp Tyr Gly Glu Gly  Val Asn Gly 
    1130                 1135                 1140             


Gln Phe  Asn Glu Asp Gly Ser  Phe Ile Gly Gln Tyr  Ser Gly Lys 
    1145                 1150                 1155             


Lys Glu  Lys Glu Pro Ala Glu  Gly Asn Glu Ser Ser  Glu Ala Pro 
    1160                 1165                 1170             


Ser Pro  Val Asn Ala Met Asn  Ser Phe Val 
    1175                 1180             


<210>  9499
<211>  431
<212>  PRT
<213>  Homo Sapiens

<400>  9499

Met Gln Leu Lys Ile Met Pro Lys Lys Lys Arg Leu Ser Ala Gly Arg 
1               5                   10                  15      


Val Pro Leu Ile Leu Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val 
            20                  25                  30          


Pro Leu Asp Leu Val Gln Pro Pro Thr Ile Thr Gln Gln Ser Pro Lys 
        35                  40                  45              


Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile Val Ile Gln Cys Glu Ala 
    50                  55                  60                  


Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp Thr Arg Asn Gly Thr His 
65                  70                  75                  80  


Phe Asp Ile Asp Lys Asp Pro Leu Val Thr Met Lys Pro Gly Thr Gly 
                85                  90                  95      


Thr Leu Ile Ile Asn Ile Met Ser Glu Gly Lys Ala Glu Thr Tyr Glu 
            100                 105                 110         


Gly Val Tyr Gln Cys Thr Ala Arg Asn Glu Arg Gly Ala Ala Val Ser 
        115                 120                 125             


Asn Asn Ile Val Val Arg Pro Ser Arg Ser Pro Leu Trp Thr Lys Glu 
    130                 135                 140                 


Lys Leu Glu Pro Ile Thr Leu Gln Ser Gly Gln Ser Leu Val Leu Pro 
145                 150                 155                 160 


Cys Arg Pro Pro Ile Gly Leu Pro Pro Pro Ile Ile Phe Trp Met Asp 
                165                 170                 175     


Asn Ser Phe Gln Arg Leu Pro Gln Ser Glu Arg Val Ser Gln Gly Leu 
            180                 185                 190         


Asn Gly Asp Leu Tyr Phe Ser Asn Val Leu Pro Glu Asp Thr Arg Glu 
        195                 200                 205             


Asp Tyr Ile Cys Tyr Ala Arg Phe Asn His Thr Gln Thr Ile Gln Gln 
    210                 215                 220                 


Lys Gln Pro Ile Ser Val Lys Val Ile Ser Val Asp Glu Leu Asn Asp 
225                 230                 235                 240 


Thr Ile Ala Ala Asn Leu Ser Asp Thr Glu Phe Tyr Gly Ala Lys Ser 
                245                 250                 255     


Ser Arg Glu Arg Pro Pro Thr Phe Leu Thr Pro Glu Gly Asn Ala Ser 
            260                 265                 270         


Asn Lys Glu Glu Leu Arg Gly Asn Val Leu Ser Leu Glu Cys Ile Ala 
        275                 280                 285             


Glu Gly Leu Pro Thr Pro Ile Ile Tyr Trp Ala Lys Glu Asp Gly Met 
    290                 295                 300                 


Leu Pro Lys Asn Arg Thr Val Tyr Lys Asn Phe Glu Lys Thr Leu Gln 
305                 310                 315                 320 


Ile Ile His Val Ser Glu Ala Asp Ser Gly Asn Tyr Gln Cys Ile Ala 
                325                 330                 335     


Lys Asn Ala Leu Gly Ala Ile His His Thr Ile Ser Val Arg Val Lys 
            340                 345                 350         


Ala Ala Pro Tyr Trp Ile Thr Ala Pro Gln Asn Leu Val Leu Ser Pro 
        355                 360                 365             


Gly Glu Asp Gly Thr Leu Ile Cys Arg Ala Asn Gly Asn Pro Lys Pro 
    370                 375                 380                 


Arg Ile Ser Trp Leu Thr Asn Gly Val Pro Ile Glu Ile Ala Pro Asp 
385                 390                 395                 400 


Asp Pro Ser Arg Lys Ile Asp Gly Asp Thr Ile Ile Phe Ser Asn Val 
                405                 410                 415     


Gln Glu Arg Ser Ser Ala Val Tyr Gln Cys Asn Ala Ser Asn Glu 
            420                 425                 430     


<210>  9500
<211>  771
<212>  PRT
<213>  Homo Sapiens

<400>  9500

Met Gln Leu Lys Ile Met Pro Lys Lys Lys Arg Leu Ser Ala Gly Arg 
1               5                   10                  15      


Val Pro Leu Ile Leu Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val 
            20                  25                  30          


Pro Leu Asp Leu Val Gln Pro Pro Thr Ile Thr Gln Gln Ser Pro Lys 
        35                  40                  45              


Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile Val Ile Gln Cys Glu Ala 
    50                  55                  60                  


Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp Thr Arg Asn Gly Thr His 
65                  70                  75                  80  


Phe Asp Ile Asp Lys Asp Pro Leu Val Thr Met Lys Pro Gly Thr Gly 
                85                  90                  95      


Thr Leu Ile Ile Asn Ile Met Ser Glu Gly Lys Ala Glu Thr Tyr Glu 
            100                 105                 110         


Gly Val Tyr Gln Cys Thr Ala Arg Asn Glu Arg Gly Ala Ala Val Ser 
        115                 120                 125             


Asn Asn Ile Val Val Arg Pro Ser Arg Ser Pro Leu Trp Thr Lys Glu 
    130                 135                 140                 


Lys Leu Glu Pro Ile Thr Leu Gln Ser Gly Gln Ser Leu Val Leu Pro 
145                 150                 155                 160 


Cys Arg Pro Pro Ile Gly Leu Pro Pro Pro Ile Ile Phe Trp Met Asp 
                165                 170                 175     


Asn Ser Phe Gln Arg Leu Pro Gln Ser Glu Arg Val Ser Gln Gly Leu 
            180                 185                 190         


Asn Gly Asp Leu Tyr Phe Ser Asn Val Leu Pro Glu Asp Thr Arg Glu 
        195                 200                 205             


Asp Tyr Ile Cys Tyr Ala Arg Phe Asn His Thr Gln Thr Ile Gln Gln 
    210                 215                 220                 


Lys Gln Pro Ile Ser Val Lys Val Ile Ser Val Asp Glu Leu Asn Asp 
225                 230                 235                 240 


Thr Ile Ala Ala Asn Leu Ser Asp Thr Glu Phe Tyr Gly Ala Lys Ser 
                245                 250                 255     


Ser Arg Glu Arg Pro Pro Thr Phe Leu Thr Pro Glu Gly Asn Ala Ser 
            260                 265                 270         


Asn Lys Glu Glu Leu Arg Gly Asn Val Leu Ser Leu Glu Cys Ile Ala 
        275                 280                 285             


Glu Gly Leu Pro Thr Pro Ile Ile Tyr Trp Ala Lys Glu Asp Gly Met 
    290                 295                 300                 


Leu Pro Lys Asn Arg Thr Val Tyr Lys Asn Phe Glu Lys Thr Leu Gln 
305                 310                 315                 320 


Ile Ile His Val Ser Glu Ala Asp Ser Gly Asn Tyr Gln Cys Ile Ala 
                325                 330                 335     


Lys Asn Ala Leu Gly Ala Ile His His Thr Ile Ser Val Arg Val Lys 
            340                 345                 350         


Ala Ala Pro Tyr Trp Ile Thr Ala Pro Gln Asn Leu Val Leu Ser Pro 
        355                 360                 365             


Gly Glu Asp Gly Thr Leu Ile Cys Arg Ala Asn Gly Asn Pro Lys Pro 
    370                 375                 380                 


Arg Ile Ser Trp Leu Thr Asn Gly Val Pro Ile Glu Ile Ala Pro Asp 
385                 390                 395                 400 


Asp Pro Ser Arg Lys Ile Asp Gly Asp Thr Ile Ile Phe Ser Asn Val 
                405                 410                 415     


Gln Glu Arg Ser Ser Ala Val Tyr Gln Cys Asn Ala Ser Asn Glu Tyr 
            420                 425                 430         


Gly Tyr Leu Leu Ala Asn Ala Phe Val Asn Val Leu Ala Glu Pro Pro 
        435                 440                 445             


Arg Ile Leu Thr Pro Ala Asn Thr Leu Tyr Gln Val Ile Ala Asn Arg 
    450                 455                 460                 


Pro Ala Leu Leu Asp Cys Ala Phe Phe Gly Ser Pro Leu Pro Thr Ile 
465                 470                 475                 480 


Glu Trp Phe Lys Gly Ala Lys Gly Ser Ala Leu His Glu Asp Ile Tyr 
                485                 490                 495     


Val Leu His Glu Asn Gly Thr Leu Glu Ile Pro Val Ala Gln Lys Asp 
            500                 505                 510         


Ser Thr Gly Thr Tyr Thr Cys Val Ala Arg Asn Lys Leu Gly Met Ala 
        515                 520                 525             


Lys Asn Glu Val His Leu Glu Ile Lys Asp Pro Thr Trp Ile Val Lys 
    530                 535                 540                 


Gln Pro Glu Tyr Ala Val Val Gln Arg Gly Ser Met Val Ser Phe Glu 
545                 550                 555                 560 


Cys Lys Val Lys His Asp His Thr Leu Ser Leu Thr Val Leu Trp Leu 
                565                 570                 575     


Lys Asp Asn Arg Glu Leu Pro Ser Asp Glu Arg Phe Thr Val Asp Lys 
            580                 585                 590         


Asp His Leu Val Val Ala Asp Val Ser Asp Asp Asp Ser Gly Thr Tyr 
        595                 600                 605             


Thr Cys Val Ala Asn Thr Thr Leu Asp Ser Val Ser Ala Ser Ala Val 
    610                 615                 620                 


Leu Ser Val Val Asp Val Pro Asn Pro Pro Phe Asp Leu Glu Leu Thr 
625                 630                 635                 640 


Asp Gln Leu Asp Lys Ser Val Gln Leu Ser Trp Thr Pro Gly Asp Asp 
                645                 650                 655     


Asn Asn Ser Pro Ile Thr Lys Phe Ile Ile Glu Tyr Glu Asp Ala Met 
            660                 665                 670         


His Lys Pro Gly Leu Trp His His Gln Thr Glu Val Ser Gly Thr Gln 
        675                 680                 685             


Thr Thr Ala Gln Leu Lys Leu Ser Pro Tyr Val Asn Tyr Ser Phe Arg 
    690                 695                 700                 


Val Met Ala Val Asn Ser Ile Gly Lys Ser Leu Pro Ser Glu Ala Ser 
705                 710                 715                 720 


Glu Gln Tyr Leu Thr Lys Ala Ser Glu Pro Asp Lys Asn Pro Thr Ala 
                725                 730                 735     


Val Glu Gly Leu Gly Ser Glu Pro Asp Asn Leu Val Ile Thr Trp Lys 
            740                 745                 750         


Pro Leu Asn Gly Phe Glu Ser Asn Gly Pro Gly Leu Gln Thr Ser Thr 
        755                 760                 765             


Ala Ser Phe 
    770     


<210>  9501
<211>  61
<212>  PRT
<213>  Homo Sapiens

<400>  9501

Met Gln Leu Lys Ile Met Pro Lys Lys Lys Arg Leu Ser Ala Gly Arg 
1               5                   10                  15      


Val Pro Leu Ile Leu Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val 
            20                  25                  30          


Pro Leu Asp Pro Lys Leu Leu Glu Asp Leu Val Gln Pro Pro Thr Ile 
        35                  40                  45              


Thr Gln Gln Ser Pro Lys Asp Tyr Ile Ile Asp Pro Arg 
    50                  55                  60      


<210>  9502
<211>  118
<212>  PRT
<213>  Homo Sapiens

<400>  9502

Met Gln Leu Lys Ile Met Pro Lys Lys Lys Arg Leu Ser Ala Gly Arg 
1               5                   10                  15      


Val Pro Leu Ile Leu Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val 
            20                  25                  30          


Pro Leu Asp Pro Lys Leu Leu Glu Asp Leu Val Gln Pro Pro Thr Ile 
        35                  40                  45              


Thr Gln Gln Ser Pro Lys Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile 
    50                  55                  60                  


Val Ile Gln Cys Glu Ala Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp 
65                  70                  75                  80  


Thr Arg Asn Gly Thr His Phe Asp Ile Asp Lys Asp Pro Leu Val Thr 
                85                  90                  95      


Met Lys Pro Gly Thr Gly Thr Leu Ile Ile Asn Ile Met Ser Glu Gly 
            100                 105                 110         


Lys Ala Glu Thr Tyr Glu 
        115             


<210>  9503
<211>  1192
<212>  PRT
<213>  Homo Sapiens

<400>  9503

Met Gln Leu Lys Ile Met Pro Lys Lys Lys Arg Leu Ser Ala Gly Arg 
1               5                   10                  15      


Val Pro Leu Ile Leu Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val 
            20                  25                  30          


Pro Leu Asp Pro Lys Leu Leu Glu Asp Leu Val Gln Pro Pro Thr Ile 
        35                  40                  45              


Thr Gln Gln Ser Pro Lys Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile 
    50                  55                  60                  


Val Ile Gln Cys Glu Ala Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp 
65                  70                  75                  80  


Thr Arg Asn Gly Thr His Phe Asp Ile Asp Lys Asp Pro Leu Val Thr 
                85                  90                  95      


Met Lys Pro Gly Thr Gly Thr Leu Ile Ile Asn Ile Met Ser Glu Gly 
            100                 105                 110         


Lys Ala Glu Thr Tyr Glu Gly Val Tyr Gln Cys Thr Ala Arg Asn Glu 
        115                 120                 125             


Arg Gly Ala Ala Val Ser Asn Asn Ile Val Val Arg Pro Ser Arg Ser 
    130                 135                 140                 


Pro Leu Trp Thr Lys Glu Lys Leu Glu Pro Ile Thr Leu Gln Ser Gly 
145                 150                 155                 160 


Gln Ser Leu Val Leu Pro Cys Arg Pro Pro Ile Gly Leu Pro Pro Pro 
                165                 170                 175     


Ile Ile Phe Trp Met Asp Asn Ser Phe Gln Arg Leu Pro Gln Ser Glu 
            180                 185                 190         


Arg Val Ser Gln Gly Leu Asn Gly Asp Leu Tyr Phe Ser Asn Val Leu 
        195                 200                 205             


Pro Glu Asp Thr Arg Glu Asp Tyr Ile Cys Tyr Ala Arg Phe Asn His 
    210                 215                 220                 


Thr Gln Thr Ile Gln Gln Lys Gln Pro Ile Ser Val Lys Val Ile Ser 
225                 230                 235                 240 


Ala Lys Ser Ser Arg Glu Arg Pro Pro Thr Phe Leu Thr Pro Glu Gly 
                245                 250                 255     


Asn Ala Ser Asn Lys Glu Glu Leu Arg Gly Asn Val Leu Ser Leu Glu 
            260                 265                 270         


Cys Ile Ala Glu Gly Leu Pro Thr Pro Ile Ile Tyr Trp Ala Lys Glu 
        275                 280                 285             


Asp Gly Met Leu Pro Lys Asn Arg Thr Val Tyr Lys Asn Phe Glu Lys 
    290                 295                 300                 


Thr Leu Gln Ile Ile His Val Ser Glu Ala Asp Ser Gly Asn Tyr Gln 
305                 310                 315                 320 


Cys Ile Ala Lys Asn Ala Leu Gly Ala Ile His His Thr Ile Ser Val 
                325                 330                 335     


Arg Val Lys Ala Ala Pro Tyr Trp Ile Thr Ala Pro Gln Asn Leu Val 
            340                 345                 350         


Leu Ser Pro Gly Glu Asp Gly Thr Leu Ile Cys Arg Ala Asn Gly Asn 
        355                 360                 365             


Pro Lys Pro Arg Ile Ser Trp Leu Thr Asn Gly Val Pro Ile Glu Ile 
    370                 375                 380                 


Ala Pro Asp Asp Pro Ser Arg Lys Ile Asp Gly Asp Thr Ile Ile Phe 
385                 390                 395                 400 


Ser Asn Val Gln Glu Arg Ser Ser Ala Val Tyr Gln Cys Asn Ala Ser 
                405                 410                 415     


Asn Glu Tyr Gly Tyr Leu Leu Ala Asn Ala Phe Val Asn Val Leu Ala 
            420                 425                 430         


Glu Pro Pro Arg Ile Leu Thr Pro Ala Asn Thr Leu Tyr Gln Val Ile 
        435                 440                 445             


Ala Asn Arg Pro Ala Leu Leu Asp Cys Ala Phe Phe Gly Ser Pro Leu 
    450                 455                 460                 


Pro Thr Ile Glu Trp Phe Lys Gly Ala Lys Gly Ser Ala Leu His Glu 
465                 470                 475                 480 


Asp Ile Tyr Val Leu His Glu Asn Gly Thr Leu Glu Ile Pro Val Ala 
                485                 490                 495     


Gln Lys Asp Ser Thr Gly Thr Tyr Thr Cys Val Ala Arg Asn Lys Leu 
            500                 505                 510         


Gly Met Ala Lys Asn Glu Val His Leu Glu Ile Lys Asp Pro Thr Trp 
        515                 520                 525             


Ile Val Lys Gln Pro Glu Tyr Ala Val Val Gln Arg Gly Ser Met Val 
    530                 535                 540                 


Ser Phe Glu Cys Lys Val Lys His Asp His Thr Leu Ser Leu Thr Val 
545                 550                 555                 560 


Leu Trp Leu Lys Asp Asn Arg Glu Leu Pro Ser Asp Glu Arg Phe Thr 
                565                 570                 575     


Val Asp Lys Asp His Leu Val Val Ala Asp Val Ser Asp Asp Asp Ser 
            580                 585                 590         


Gly Thr Tyr Thr Cys Val Ala Asn Thr Thr Leu Asp Ser Val Ser Ala 
        595                 600                 605             


Ser Ala Val Leu Ser Val Val Ala Pro Thr Pro Thr Pro Ala Pro Val 
    610                 615                 620                 


Tyr Asp Val Pro Asn Pro Pro Phe Asp Leu Glu Leu Thr Asp Gln Leu 
625                 630                 635                 640 


Asp Lys Ser Val Gln Leu Ser Trp Thr Pro Gly Asp Asp Asn Asn Ser 
                645                 650                 655     


Pro Ile Thr Lys Phe Ile Ile Glu Tyr Glu Asp Ala Met His Lys Pro 
            660                 665                 670         


Gly Leu Trp His His Gln Thr Glu Val Ser Gly Thr Gln Thr Thr Ala 
        675                 680                 685             


Gln Leu Lys Leu Ser Pro Tyr Val Asn Tyr Ser Phe Arg Val Met Ala 
    690                 695                 700                 


Val Asn Ser Ile Gly Lys Ser Leu Pro Ser Glu Ala Ser Glu Gln Tyr 
705                 710                 715                 720 


Leu Thr Lys Ala Ser Glu Pro Asp Lys Asn Pro Thr Ala Val Glu Gly 
                725                 730                 735     


Leu Gly Ser Glu Pro Asp Asn Leu Val Ile Thr Trp Lys Pro Leu Asn 
            740                 745                 750         


Gly Phe Glu Ser Asn Gly Pro Gly Leu Gln Tyr Lys Val Ser Trp Arg 
        755                 760                 765             


Gln Lys Asp Gly Asp Asp Glu Trp Thr Ser Val Val Val Ala Asn Val 
    770                 775                 780                 


Ser Lys Tyr Ile Val Ser Gly Thr Pro Thr Phe Val Pro Tyr Leu Ile 
785                 790                 795                 800 


Lys Val Gln Ala Leu Asn Asp Met Gly Phe Ala Pro Glu Pro Ala Val 
                805                 810                 815     


Val Met Gly His Ser Gly Glu Asp Leu Pro Met Val Ala Pro Gly Asn 
            820                 825                 830         


Val Arg Val Asn Val Val Asn Ser Thr Leu Ala Glu Val His Trp Asp 
        835                 840                 845             


Pro Val Pro Leu Lys Ser Ile Arg Gly His Leu Gln Gly Tyr Arg Ile 
    850                 855                 860                 


Tyr Tyr Trp Lys Thr Gln Ser Ser Ser Lys Arg Asn Arg Arg His Ile 
865                 870                 875                 880 


Glu Lys Lys Ile Leu Thr Phe Gln Gly Ser Lys Thr His Gly Met Leu 
                885                 890                 895     


Pro Gly Leu Glu Pro Phe Ser His Tyr Thr Leu Asn Val Arg Val Val 
            900                 905                 910         


Asn Gly Lys Gly Glu Gly Pro Ala Ser Pro Asp Arg Val Phe Asn Thr 
        915                 920                 925             


Pro Glu Gly Val Pro Ser Ala Pro Ser Ser Leu Lys Ile Val Asn Pro 
    930                 935                 940                 


Thr Leu Asp Ser Leu Thr Leu Glu Trp Asp Pro Pro Ser His Pro Asn 
945                 950                 955                 960 


Gly Ile Leu Thr Glu Tyr Thr Leu Lys Tyr Gln Pro Ile Asn Ser Thr 
                965                 970                 975     


His Glu Leu Gly Pro Leu Val Asp Leu Lys Ile Pro Ala Asn Lys Thr 
            980                 985                 990         


Arg Trp Thr Leu Lys Asn Leu Asn  Phe Ser Thr Arg Tyr  Lys Phe Tyr 
        995                 1000                 1005             


Phe Tyr  Ala Gln Thr Ser Ala  Gly Ser Gly Ser Gln  Ile Thr Glu 
    1010                 1015                 1020             


Glu Ala  Val Thr Thr Val Asp  Glu Ala Gly Ile Leu  Pro Pro Asp 
    1025                 1030                 1035             


Val Gly  Ala Gly Lys Ala Met  Ala Ser Arg Gln Val  Asp Ile Ala 
    1040                 1045                 1050             


Thr Gln  Gly Trp Phe Ile Gly  Leu Met Cys Ala Val  Ala Leu Leu 
    1055                 1060                 1065             


Ile Leu  Ile Leu Leu Ile Val  Cys Phe Ile Arg Arg  Asn Lys Gly 
    1070                 1075                 1080             


Gly Lys  Tyr Pro Val Lys Glu  Lys Glu Asp Ala His  Ala Asp Pro 
    1085                 1090                 1095             


Glu Ile  Gln Pro Met Lys Glu  Asp Asp Gly Thr Phe  Gly Glu Tyr 
    1100                 1105                 1110             


Ser Asp  Ala Glu Asp His Lys  Pro Leu Lys Lys Gly  Ser Arg Thr 
    1115                 1120                 1125             


Pro Ser  Asp Arg Thr Val Lys  Lys Glu Asp Ser Asp  Asp Ser Leu 
    1130                 1135                 1140             


Val Asp  Tyr Gly Glu Gly Val  Asn Gly Gln Phe Asn  Glu Asp Gly 
    1145                 1150                 1155             


Ser Phe  Ile Gly Gln Tyr Ser  Gly Lys Lys Glu Lys  Glu Pro Ala 
    1160                 1165                 1170             


Glu Gly  Asn Glu Ser Ser Glu  Ala Pro Ser Pro Val  Asn Ala Met 
    1175                 1180                 1185             


Asn Ser  Phe Val 
    1190         


<210>  9504
<211>  1304
<212>  PRT
<213>  Homo Sapiens

<400>  9504

Met Gln Leu Lys Ile Met Pro Lys Lys Lys Arg Leu Ser Ala Gly Arg 
1               5                   10                  15      


Val Pro Leu Ile Leu Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val 
            20                  25                  30          


Pro Leu Asp Pro Lys Leu Leu Glu Asp Leu Val Gln Pro Pro Thr Ile 
        35                  40                  45              


Thr Gln Gln Ser Pro Lys Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile 
    50                  55                  60                  


Val Ile Gln Cys Glu Ala Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp 
65                  70                  75                  80  


Thr Arg Asn Gly Thr His Phe Asp Ile Asp Lys Asp Pro Leu Val Thr 
                85                  90                  95      


Met Lys Pro Gly Thr Gly Thr Leu Ile Ile Asn Ile Met Ser Glu Gly 
            100                 105                 110         


Lys Ala Glu Thr Tyr Glu Gly Val Tyr Gln Cys Thr Ala Arg Asn Glu 
        115                 120                 125             


Arg Gly Ala Ala Val Ser Asn Asn Ile Val Val Arg Pro Ser Arg Ser 
    130                 135                 140                 


Pro Leu Trp Thr Lys Glu Lys Leu Glu Pro Ile Thr Leu Gln Ser Gly 
145                 150                 155                 160 


Gln Ser Leu Val Leu Pro Cys Arg Pro Pro Ile Gly Leu Pro Pro Pro 
                165                 170                 175     


Ile Ile Phe Trp Met Asp Asn Ser Phe Gln Arg Leu Pro Gln Ser Glu 
            180                 185                 190         


Arg Val Ser Gln Gly Leu Asn Gly Asp Leu Tyr Phe Ser Asn Val Leu 
        195                 200                 205             


Pro Glu Asp Thr Arg Glu Asp Tyr Ile Cys Tyr Ala Arg Phe Asn His 
    210                 215                 220                 


Thr Gln Thr Ile Gln Gln Lys Gln Pro Ile Ser Val Lys Val Ile Ser 
225                 230                 235                 240 


Val Asp Glu Leu Asn Asp Thr Ile Ala Ala Asn Leu Ser Asp Thr Glu 
                245                 250                 255     


Phe Tyr Gly Ala Lys Ser Ser Arg Glu Arg Pro Pro Thr Phe Leu Thr 
            260                 265                 270         


Pro Glu Gly Asn Ala Ser Asn Lys Glu Glu Leu Arg Gly Asn Val Leu 
        275                 280                 285             


Ser Leu Glu Cys Ile Ala Glu Gly Leu Pro Thr Pro Ile Ile Tyr Trp 
    290                 295                 300                 


Ala Lys Glu Asp Gly Met Leu Pro Lys Asn Arg Thr Val Tyr Lys Asn 
305                 310                 315                 320 


Phe Glu Lys Thr Leu Gln Ile Ile His Val Ser Glu Ala Asp Ser Gly 
                325                 330                 335     


Asn Tyr Gln Cys Ile Ala Lys Asn Ala Leu Gly Ala Ile His His Thr 
            340                 345                 350         


Ile Ser Val Arg Val Lys Ala Ala Pro Tyr Trp Ile Thr Ala Pro Gln 
        355                 360                 365             


Asn Leu Val Leu Ser Pro Gly Glu Asp Gly Thr Leu Ile Cys Arg Ala 
    370                 375                 380                 


Asn Gly Asn Pro Lys Pro Arg Ile Ser Trp Leu Thr Asn Gly Val Pro 
385                 390                 395                 400 


Ile Glu Ile Ala Pro Asp Asp Pro Ser Arg Lys Ile Asp Gly Asp Thr 
                405                 410                 415     


Ile Ile Phe Ser Asn Val Gln Glu Arg Ser Ser Ala Val Tyr Gln Cys 
            420                 425                 430         


Asn Ala Ser Asn Glu Tyr Gly Tyr Leu Leu Ala Asn Ala Phe Val Asn 
        435                 440                 445             


Val Leu Ala Glu Pro Pro Arg Ile Leu Thr Pro Ala Asn Thr Leu Tyr 
    450                 455                 460                 


Gln Val Ile Ala Asn Arg Pro Ala Leu Leu Asp Cys Ala Phe Phe Gly 
465                 470                 475                 480 


Ser Pro Leu Pro Thr Ile Glu Trp Phe Lys Gly Ala Lys Gly Ser Ala 
                485                 490                 495     


Leu His Glu Asp Ile Tyr Val Leu His Glu Asn Gly Thr Leu Glu Ile 
            500                 505                 510         


Pro Val Ala Gln Lys Asp Ser Thr Gly Thr Tyr Thr Cys Val Ala Arg 
        515                 520                 525             


Asn Lys Leu Gly Met Ala Lys Asn Glu Val His Leu Glu Ile Lys Asp 
    530                 535                 540                 


Pro Thr Trp Ile Val Lys Gln Pro Glu Tyr Ala Val Val Gln Arg Gly 
545                 550                 555                 560 


Ser Met Val Ser Phe Glu Cys Lys Val Lys His Asp His Thr Leu Ser 
                565                 570                 575     


Leu Thr Val Leu Trp Leu Lys Asp Asn Arg Glu Leu Pro Ser Asp Glu 
            580                 585                 590         


Arg Phe Thr Val Asp Lys Asp His Leu Val Val Ala Asp Val Ser Asp 
        595                 600                 605             


Asp Asp Ser Gly Thr Tyr Thr Cys Val Ala Asn Thr Thr Leu Asp Ser 
    610                 615                 620                 


Val Ser Ala Ser Ala Val Leu Ser Val Val Ala Pro Thr Pro Thr Pro 
625                 630                 635                 640 


Ala Pro Val Tyr Asp Val Pro Asn Pro Pro Phe Asp Leu Glu Leu Thr 
                645                 650                 655     


Asp Gln Leu Asp Lys Ser Val Gln Leu Ser Trp Thr Pro Gly Asp Asp 
            660                 665                 670         


Asn Asn Ser Pro Ile Thr Lys Phe Ile Ile Glu Tyr Glu Asp Ala Met 
        675                 680                 685             


His Lys Pro Gly Leu Trp His His Gln Thr Glu Val Ser Gly Thr Gln 
    690                 695                 700                 


Thr Thr Ala Gln Leu Lys Leu Ser Pro Tyr Val Asn Tyr Ser Phe Arg 
705                 710                 715                 720 


Val Met Ala Val Asn Ser Ile Gly Lys Ser Leu Pro Ser Glu Ala Ser 
                725                 730                 735     


Glu Gln Tyr Leu Thr Lys Ala Ser Glu Pro Asp Lys Asn Pro Thr Ala 
            740                 745                 750         


Val Glu Gly Leu Gly Ser Glu Pro Asp Asn Leu Val Ile Thr Trp Lys 
        755                 760                 765             


Pro Leu Asn Gly Phe Glu Ser Asn Gly Pro Gly Leu Gln Tyr Lys Val 
    770                 775                 780                 


Ser Trp Arg Gln Lys Asp Gly Asp Asp Glu Trp Thr Ser Val Val Val 
785                 790                 795                 800 


Ala Asn Val Ser Lys Tyr Ile Val Ser Gly Thr Pro Thr Phe Val Pro 
                805                 810                 815     


Tyr Leu Ile Lys Val Gln Ala Leu Asn Asp Met Gly Phe Ala Pro Glu 
            820                 825                 830         


Pro Ala Val Val Met Gly His Ser Gly Glu Asp Leu Pro Met Val Ala 
        835                 840                 845             


Pro Gly Asn Val Arg Val Asn Val Val Asn Ser Thr Leu Ala Glu Val 
    850                 855                 860                 


His Trp Asp Pro Val Pro Leu Lys Ser Ile Arg Gly His Leu Gln Gly 
865                 870                 875                 880 


Tyr Arg Ile Tyr Tyr Trp Lys Thr Gln Ser Ser Ser Lys Arg Asn Arg 
                885                 890                 895     


Arg His Ile Glu Lys Lys Ile Leu Thr Phe Gln Gly Ser Lys Thr His 
            900                 905                 910         


Gly Met Leu Pro Gly Leu Glu Pro Phe Ser His Tyr Thr Leu Asn Val 
        915                 920                 925             


Arg Val Val Asn Gly Lys Gly Glu Gly Pro Ala Ser Pro Asp Arg Val 
    930                 935                 940                 


Phe Asn Thr Pro Glu Gly Val Pro Ser Ala Pro Ser Ser Leu Lys Ile 
945                 950                 955                 960 


Val Asn Pro Thr Leu Asp Ser Leu Thr Leu Glu Trp Asp Pro Pro Ser 
                965                 970                 975     


His Pro Asn Gly Ile Leu Thr Glu Tyr Thr Leu Lys Tyr Gln Pro Ile 
            980                 985                 990         


Asn Ser Thr His Glu Leu Gly Pro  Leu Val Asp Leu Lys  Ile Pro Ala 
        995                 1000                 1005             


Asn Lys  Thr Arg Trp Thr Leu  Lys Asn Leu Asn Phe  Ser Thr Arg 
    1010                 1015                 1020             


Tyr Lys  Phe Tyr Phe Tyr Ala  Gln Thr Ser Ala Gly  Ser Gly Ser 
    1025                 1030                 1035             


Gln Ile  Thr Glu Glu Ala Val  Thr Thr Val Asp Glu  Ala Gly Ile 
    1040                 1045                 1050             


Leu Pro  Pro Asp Val Gly Ala  Gly Lys Val Gln Ala  Val Asn Pro 
    1055                 1060                 1065             


Arg Ile  Ser Asn Leu Thr Ala  Ala Ala Ala Glu Thr  Tyr Ala Asn 
    1070                 1075                 1080             


Ile Ser  Trp Glu Tyr Glu Gly  Pro Glu His Val Asn  Phe Tyr Val 
    1085                 1090                 1095             


Glu Tyr  Gly Val Ala Gly Ser  Lys Glu Glu Trp Arg  Lys Glu Ile 
    1100                 1105                 1110             


Val Asn  Gly Ser Arg Ser Phe  Phe Gly Leu Lys Gly  Leu Met Pro 
    1115                 1120                 1125             


Gly Thr  Ala Tyr Lys Val Arg  Val Gly Ala Val Gly  Asp Ser Gly 
    1130                 1135                 1140             


Phe Val  Ser Ser Glu Asp Val  Phe Glu Thr Gly Pro  Ala Met Ala 
    1145                 1150                 1155             


Ser Arg  Gln Val Asp Ile Ala  Thr Gln Gly Trp Phe  Ile Gly Leu 
    1160                 1165                 1170             


Met Cys  Ala Val Ala Leu Leu  Ile Leu Ile Leu Leu  Ile Val Cys 
    1175                 1180                 1185             


Phe Ile  Arg Arg Asn Lys Gly  Gly Lys Tyr Pro Val  Lys Glu Lys 
    1190                 1195                 1200             


Glu Asp  Ala His Ala Asp Pro  Glu Ile Gln Pro Met  Lys Glu Asp 
    1205                 1210                 1215             


Asp Gly  Thr Phe Gly Glu Tyr  Ser Asp Ala Glu Asp  His Lys Pro 
    1220                 1225                 1230             


Leu Lys  Lys Gly Ser Arg Thr  Pro Ser Asp Arg Thr  Val Lys Lys 
    1235                 1240                 1245             


Glu Asp  Ser Asp Asp Ser Leu  Val Asp Tyr Gly Glu  Gly Val Asn 
    1250                 1255                 1260             


Gly Gln  Phe Asn Glu Asp Gly  Ser Phe Ile Gly Gln  Tyr Ser Gly 
    1265                 1270                 1275             


Lys Lys  Glu Lys Glu Pro Ala  Glu Gly Asn Glu Ser  Ser Glu Ala 
    1280                 1285                 1290             


Pro Ser  Pro Val Asn Ala Met  Asn Ser Phe Val 
    1295                 1300                 


<210>  9505
<211>  1211
<212>  PRT
<213>  Homo Sapiens

<400>  9505

Met Gln Leu Lys Ile Met Pro Lys Lys Lys Arg Leu Ser Ala Gly Arg 
1               5                   10                  15      


Val Pro Leu Ile Leu Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val 
            20                  25                  30          


Pro Leu Asp Pro Lys Leu Leu Glu Asp Leu Val Gln Pro Pro Thr Ile 
        35                  40                  45              


Thr Gln Gln Ser Pro Lys Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile 
    50                  55                  60                  


Val Ile Gln Cys Glu Ala Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp 
65                  70                  75                  80  


Thr Arg Asn Gly Thr His Phe Asp Ile Asp Lys Asp Pro Leu Val Thr 
                85                  90                  95      


Met Lys Pro Gly Thr Gly Thr Leu Ile Ile Asn Ile Met Ser Glu Gly 
            100                 105                 110         


Lys Ala Glu Thr Tyr Glu Gly Val Tyr Gln Cys Thr Ala Arg Asn Glu 
        115                 120                 125             


Arg Gly Ala Ala Val Ser Asn Asn Ile Val Val Arg Pro Ser Arg Ser 
    130                 135                 140                 


Pro Leu Trp Thr Lys Glu Lys Leu Glu Pro Ile Thr Leu Gln Ser Gly 
145                 150                 155                 160 


Gln Ser Leu Val Leu Pro Cys Arg Pro Pro Ile Gly Leu Pro Pro Pro 
                165                 170                 175     


Ile Ile Phe Trp Met Asp Asn Ser Phe Gln Arg Leu Pro Gln Ser Glu 
            180                 185                 190         


Arg Val Ser Gln Gly Leu Asn Gly Asp Leu Tyr Phe Ser Asn Val Leu 
        195                 200                 205             


Pro Glu Asp Thr Arg Glu Asp Tyr Ile Cys Tyr Ala Arg Phe Asn His 
    210                 215                 220                 


Thr Gln Thr Ile Gln Gln Lys Gln Pro Ile Ser Val Lys Val Ile Ser 
225                 230                 235                 240 


Val Asp Glu Leu Asn Asp Thr Ile Ala Ala Asn Leu Ser Asp Thr Glu 
                245                 250                 255     


Phe Tyr Gly Ala Lys Ser Ser Arg Glu Arg Pro Pro Thr Phe Leu Thr 
            260                 265                 270         


Pro Glu Gly Asn Ala Ser Asn Lys Glu Glu Leu Arg Gly Asn Val Leu 
        275                 280                 285             


Ser Leu Glu Cys Ile Ala Glu Gly Leu Pro Thr Pro Ile Ile Tyr Trp 
    290                 295                 300                 


Ala Lys Glu Asp Gly Met Leu Pro Lys Asn Arg Thr Val Tyr Lys Asn 
305                 310                 315                 320 


Phe Glu Lys Thr Leu Gln Ile Ile His Val Ser Glu Ala Asp Ser Gly 
                325                 330                 335     


Asn Tyr Gln Cys Ile Ala Lys Asn Ala Leu Gly Ala Ile His His Thr 
            340                 345                 350         


Ile Ser Val Arg Val Lys Ala Ala Pro Tyr Trp Ile Thr Ala Pro Gln 
        355                 360                 365             


Asn Leu Val Leu Ser Pro Gly Glu Asp Gly Thr Leu Ile Cys Arg Ala 
    370                 375                 380                 


Asn Gly Asn Pro Lys Pro Arg Ile Ser Trp Leu Thr Asn Gly Val Pro 
385                 390                 395                 400 


Ile Glu Ile Ala Pro Asp Asp Pro Ser Arg Lys Ile Asp Gly Asp Thr 
                405                 410                 415     


Ile Ile Phe Ser Asn Val Gln Glu Arg Ser Ser Ala Val Tyr Gln Cys 
            420                 425                 430         


Asn Ala Ser Asn Glu Tyr Gly Tyr Leu Leu Ala Asn Ala Phe Val Asn 
        435                 440                 445             


Val Leu Ala Glu Pro Pro Arg Ile Leu Thr Pro Ala Asn Thr Leu Tyr 
    450                 455                 460                 


Gln Val Ile Ala Asn Arg Pro Ala Leu Leu Asp Cys Ala Phe Phe Gly 
465                 470                 475                 480 


Ser Pro Leu Pro Thr Ile Glu Trp Phe Lys Gly Ala Lys Gly Ser Ala 
                485                 490                 495     


Leu His Glu Asp Ile Tyr Val Leu His Glu Asn Gly Thr Leu Glu Ile 
            500                 505                 510         


Pro Val Ala Gln Lys Asp Ser Thr Gly Thr Tyr Thr Cys Val Ala Arg 
        515                 520                 525             


Asn Lys Leu Gly Met Ala Lys Asn Glu Val His Leu Glu Ile Lys Asp 
    530                 535                 540                 


Pro Thr Trp Ile Val Lys Gln Pro Glu Tyr Ala Val Val Gln Arg Gly 
545                 550                 555                 560 


Ser Met Val Ser Phe Glu Cys Lys Val Lys His Asp His Thr Leu Ser 
                565                 570                 575     


Leu Thr Val Leu Trp Leu Lys Asp Asn Arg Glu Leu Pro Ser Asp Glu 
            580                 585                 590         


Arg Phe Thr Val Asp Lys Asp His Leu Val Val Ala Asp Val Ser Asp 
        595                 600                 605             


Asp Asp Ser Gly Thr Tyr Thr Cys Val Ala Asn Thr Thr Leu Asp Ser 
    610                 615                 620                 


Val Ser Ala Ser Ala Val Leu Ser Val Val Ala Pro Thr Pro Thr Pro 
625                 630                 635                 640 


Ala Pro Val Tyr Asp Val Pro Asn Pro Pro Phe Asp Leu Glu Leu Thr 
                645                 650                 655     


Asp Gln Leu Asp Lys Ser Val Gln Leu Ser Trp Thr Pro Gly Asp Asp 
            660                 665                 670         


Asn Asn Ser Pro Ile Thr Lys Phe Ile Ile Glu Tyr Glu Asp Ala Met 
        675                 680                 685             


His Lys Pro Gly Leu Trp His His Gln Thr Glu Val Ser Gly Thr Gln 
    690                 695                 700                 


Thr Thr Ala Gln Leu Lys Leu Ser Pro Tyr Val Asn Tyr Ser Phe Arg 
705                 710                 715                 720 


Val Met Ala Val Asn Ser Ile Gly Lys Ser Leu Pro Ser Glu Ala Ser 
                725                 730                 735     


Glu Gln Tyr Leu Thr Lys Ala Ser Glu Pro Asp Lys Asn Pro Thr Ala 
            740                 745                 750         


Val Glu Gly Leu Gly Ser Glu Pro Asp Asn Leu Val Ile Thr Trp Lys 
        755                 760                 765             


Pro Leu Asn Gly Phe Glu Ser Asn Gly Pro Gly Leu Gln Tyr Lys Val 
    770                 775                 780                 


Ser Trp Arg Gln Lys Asp Gly Asp Asp Glu Trp Thr Ser Val Val Val 
785                 790                 795                 800 


Ala Asn Val Ser Lys Tyr Ile Val Ser Gly Thr Pro Thr Phe Val Pro 
                805                 810                 815     


Tyr Leu Ile Lys Val Gln Ala Leu Asn Asp Met Gly Phe Ala Pro Glu 
            820                 825                 830         


Pro Ala Val Val Met Gly His Ser Gly Glu Asp Leu Pro Met Val Ala 
        835                 840                 845             


Pro Gly Asn Val Arg Val Asn Val Val Asn Ser Thr Leu Ala Glu Val 
    850                 855                 860                 


His Trp Asp Pro Val Pro Leu Lys Ser Ile Arg Gly His Leu Gln Gly 
865                 870                 875                 880 


Tyr Arg Ile Tyr Tyr Trp Lys Thr Gln Ser Ser Ser Lys Arg Asn Arg 
                885                 890                 895     


Arg His Ile Glu Lys Lys Ile Leu Thr Phe Gln Gly Ser Lys Thr His 
            900                 905                 910         


Gly Met Leu Pro Gly Leu Glu Pro Phe Ser His Tyr Thr Leu Asn Val 
        915                 920                 925             


Arg Val Val Asn Gly Lys Gly Glu Gly Pro Ala Ser Pro Asp Arg Val 
    930                 935                 940                 


Phe Asn Thr Pro Glu Gly Val Pro Ser Ala Pro Ser Ser Leu Lys Ile 
945                 950                 955                 960 


Val Asn Pro Thr Leu Asp Ser Leu Thr Leu Glu Trp Asp Pro Pro Ser 
                965                 970                 975     


His Pro Asn Gly Ile Leu Thr Glu Tyr Thr Leu Lys Tyr Gln Pro Ile 
            980                 985                 990         


Asn Ser Thr His Glu Leu Gly Pro  Leu Val Asp Leu Lys  Ile Pro Ala 
        995                 1000                 1005             


Asn Lys  Thr Arg Trp Thr Leu  Lys Asn Leu Asn Phe  Ser Thr Arg 
    1010                 1015                 1020             


Tyr Lys  Phe Tyr Phe Tyr Ala  Gln Thr Ser Ala Gly  Ser Gly Ser 
    1025                 1030                 1035             


Gln Ile  Thr Glu Glu Ala Val  Thr Thr Val Asp Glu  Ala Gly Ile 
    1040                 1045                 1050             


Leu Pro  Pro Asp Val Gly Ala  Gly Lys Ala Met Ala  Ser Arg Gln 
    1055                 1060                 1065             


Val Asp  Ile Ala Thr Gln Gly  Trp Phe Ile Gly Leu  Met Cys Ala 
    1070                 1075                 1080             


Val Ala  Leu Leu Ile Leu Ile  Leu Leu Ile Val Cys  Phe Ile Arg 
    1085                 1090                 1095             


Arg Asn  Lys Gly Gly Lys Tyr  Pro Val Lys Glu Lys  Glu Asp Ala 
    1100                 1105                 1110             


His Ala  Asp Pro Glu Ile Gln  Pro Met Lys Glu Asp  Asp Gly Thr 
    1115                 1120                 1125             


Phe Gly  Glu Tyr Ser Asp Ala  Glu Asp His Lys Pro  Leu Lys Lys 
    1130                 1135                 1140             


Gly Ser  Arg Thr Pro Ser Asp  Arg Thr Val Lys Lys  Glu Asp Ser 
    1145                 1150                 1155             


Asp Asp  Ser Leu Val Asp Tyr  Gly Glu Gly Val Asn  Gly Gln Phe 
    1160                 1165                 1170             


Asn Glu  Asp Gly Ser Phe Ile  Gly Gln Tyr Ser Gly  Lys Lys Glu 
    1175                 1180                 1185             


Lys Glu  Pro Ala Glu Gly Asn  Glu Ser Ser Glu Ala  Pro Ser Pro 
    1190                 1195                 1200             


Val Asn  Ala Met Asn Ser Phe  Val 
    1205                 1210     


<210>  9506
<211>  1304
<212>  PRT
<213>  Homo Sapiens

<400>  9506

Met Gln Leu Lys Ile Met Pro Lys Lys Lys Arg Leu Ser Ala Gly Arg 
1               5                   10                  15      


Val Pro Leu Ile Leu Phe Leu Cys Gln Met Ile Ser Ala Leu Glu Val 
            20                  25                  30          


Pro Leu Asp Pro Lys Leu Leu Glu Asp Leu Val Gln Pro Pro Thr Ile 
        35                  40                  45              


Thr Gln Gln Ser Pro Lys Asp Tyr Ile Ile Asp Pro Arg Glu Asn Ile 
    50                  55                  60                  


Val Ile Gln Cys Glu Ala Lys Gly Lys Pro Pro Pro Ser Phe Ser Trp 
65                  70                  75                  80  


Thr Arg Asn Gly Thr His Phe Asp Ile Asp Lys Asp Pro Leu Val Thr 
                85                  90                  95      


Met Lys Pro Gly Thr Gly Thr Leu Ile Ile Asn Ile Met Ser Glu Gly 
            100                 105                 110         


Lys Ala Glu Thr Tyr Glu Gly Val Tyr Gln Cys Thr Ala Arg Asn Glu 
        115                 120                 125             


Arg Gly Ala Ala Val Ser Asn Asn Ile Val Val Arg Pro Ser Arg Ser 
    130                 135                 140                 


Pro Leu Trp Thr Lys Glu Lys Leu Glu Pro Ile Thr Leu Gln Ser Gly 
145                 150                 155                 160 


Gln Ser Leu Val Leu Pro Cys Arg Pro Pro Ile Gly Leu Pro Pro Pro 
                165                 170                 175     


Ile Ile Phe Trp Met Asp Asn Ser Phe Gln Arg Leu Pro Gln Ser Glu 
            180                 185                 190         


Arg Val Ser Gln Gly Leu Asn Gly Asp Leu Tyr Phe Ser Asn Val Leu 
        195                 200                 205             


Pro Glu Asp Thr Arg Glu Asp Tyr Ile Cys Tyr Ala Arg Phe Asn His 
    210                 215                 220                 


Thr Gln Thr Ile Gln Gln Lys Gln Pro Ile Ser Val Lys Val Ile Ser 
225                 230                 235                 240 


Val Asp Glu Leu Asn Asp Thr Ile Ala Ala Asn Leu Ser Asp Thr Glu 
                245                 250                 255     


Phe Tyr Gly Ala Lys Ser Ser Arg Glu Arg Pro Pro Thr Phe Leu Thr 
            260                 265                 270         


Pro Glu Gly Asn Ala Ser Asn Lys Glu Glu Leu Arg Gly Asn Val Leu 
        275                 280                 285             


Ser Leu Glu Cys Ile Ala Glu Gly Leu Pro Thr Pro Ile Ile Tyr Trp 
    290                 295                 300                 


Ala Lys Glu Asp Gly Met Leu Pro Lys Asn Arg Thr Val Tyr Lys Asn 
305                 310                 315                 320 


Phe Glu Lys Thr Leu Gln Ile Ile His Val Ser Glu Ala Asp Ser Gly 
                325                 330                 335     


Asn Tyr Gln Cys Ile Ala Lys Asn Ala Leu Gly Ala Ile His His Thr 
            340                 345                 350         


Ile Ser Val Arg Val Lys Ala Ala Pro Tyr Trp Ile Thr Ala Pro Gln 
        355                 360                 365             


Asn Leu Val Leu Ser Pro Gly Glu Asp Gly Thr Leu Ile Cys Arg Ala 
    370                 375                 380                 


Asn Gly Asn Pro Lys Pro Arg Ile Ser Trp Leu Thr Asn Gly Val Pro 
385                 390                 395                 400 


Ile Glu Ile Ala Pro Asp Asp Pro Ser Arg Lys Ile Asp Gly Asp Thr 
                405                 410                 415     


Ile Ile Phe Ser Asn Val Gln Glu Arg Ser Ser Ala Val Tyr Gln Cys 
            420                 425                 430         


Asn Ala Ser Asn Glu Tyr Gly Tyr Leu Leu Ala Asn Ala Phe Val Asn 
        435                 440                 445             


Val Leu Ala Glu Pro Pro Arg Ile Leu Thr Pro Ala Asn Thr Leu Tyr 
    450                 455                 460                 


Gln Val Ile Ala Asn Arg Pro Ala Leu Leu Asp Cys Ala Phe Phe Gly 
465                 470                 475                 480 


Ser Pro Leu Pro Thr Ile Glu Trp Phe Lys Gly Ala Lys Gly Ser Ala 
                485                 490                 495     


Leu His Glu Asp Ile Tyr Val Leu His Glu Asn Gly Thr Leu Glu Ile 
            500                 505                 510         


Pro Val Ala Gln Lys Asp Ser Thr Gly Thr Tyr Thr Cys Val Ala Arg 
        515                 520                 525             


Asn Lys Leu Gly Met Ala Lys Asn Glu Val His Leu Glu Ile Lys Asp 
    530                 535                 540                 


Pro Thr Trp Ile Val Lys Gln Pro Glu Tyr Ala Val Val Gln Arg Gly 
545                 550                 555                 560 


Ser Met Val Ser Phe Glu Cys Lys Val Lys His Asp His Thr Leu Ser 
                565                 570                 575     


Leu Thr Val Leu Trp Leu Lys Asp Asn Arg Glu Leu Pro Ser Asp Glu 
            580                 585                 590         


Arg Phe Thr Val Asp Lys Asp His Leu Val Val Ala Asp Val Ser Asp 
        595                 600                 605             


Asp Asp Ser Gly Thr Tyr Thr Cys Val Ala Asn Thr Thr Leu Asp Ser 
    610                 615                 620                 


Val Ser Ala Ser Ala Val Leu Ser Val Val Ala Pro Thr Pro Thr Pro 
625                 630                 635                 640 


Ala Pro Val Tyr Asp Val Pro Asn Pro Pro Phe Asp Leu Glu Leu Thr 
                645                 650                 655     


Asp Gln Leu Asp Lys Ser Val Gln Leu Ser Trp Thr Pro Gly Asp Asp 
            660                 665                 670         


Asn Asn Ser Pro Ile Thr Lys Phe Ile Ile Glu Tyr Glu Asp Ala Met 
        675                 680                 685             


His Lys Pro Gly Leu Trp His His Gln Thr Glu Val Ser Gly Thr Gln 
    690                 695                 700                 


Thr Thr Ala Gln Leu Lys Leu Ser Pro Tyr Val Asn Tyr Ser Phe Arg 
705                 710                 715                 720 


Val Met Ala Val Asn Ser Ile Gly Lys Ser Leu Pro Ser Glu Ala Ser 
                725                 730                 735     


Glu Gln Tyr Leu Thr Lys Ala Ser Glu Pro Asp Lys Asn Pro Thr Ala 
            740                 745                 750         


Val Glu Gly Leu Gly Ser Glu Pro Asp Asn Leu Val Ile Thr Trp Lys 
        755                 760                 765             


Pro Leu Asn Gly Phe Glu Ser Asn Gly Pro Gly Leu Gln Tyr Lys Val 
    770                 775                 780                 


Ser Trp Arg Gln Lys Asp Gly Asp Asp Glu Trp Thr Ser Val Val Val 
785                 790                 795                 800 


Ala Asn Val Ser Lys Tyr Ile Val Ser Gly Thr Pro Thr Phe Val Pro 
                805                 810                 815     


Tyr Leu Ile Lys Val Gln Ala Leu Asn Asp Met Gly Phe Ala Pro Glu 
            820                 825                 830         


Pro Ala Val Val Met Gly His Ser Gly Glu Asp Leu Pro Met Val Ala 
        835                 840                 845             


Pro Gly Asn Val Arg Val Asn Val Val Asn Ser Thr Leu Ala Glu Val 
    850                 855                 860                 


His Trp Asp Pro Val Pro Leu Lys Ser Ile Arg Gly His Leu Gln Gly 
865                 870                 875                 880 


Tyr Arg Ile Tyr Tyr Trp Lys Thr Gln Ser Ser Ser Lys Arg Asn Arg 
                885                 890                 895     


Arg His Ile Glu Lys Lys Ile Leu Thr Phe Gln Gly Ser Lys Thr His 
            900                 905                 910         


Gly Met Leu Pro Gly Leu Glu Pro Phe Ser His Tyr Thr Leu Asn Val 
        915                 920                 925             


Arg Val Val Asn Gly Lys Gly Glu Gly Pro Ala Ser Pro Asp Arg Val 
    930                 935                 940                 


Phe Asn Thr Pro Glu Gly Val Pro Ser Ala Pro Ser Ser Leu Lys Ile 
945                 950                 955                 960 


Val Asn Pro Thr Leu Asp Ser Leu Thr Leu Glu Trp Asp Pro Pro Ser 
                965                 970                 975     


His Pro Asn Gly Ile Leu Thr Glu Tyr Thr Leu Lys Tyr Gln Pro Ile 
            980                 985                 990         


Asn Ser Thr His Glu Leu Gly Pro  Leu Val Asp Leu Lys  Ile Pro Ala 
        995                 1000                 1005             


Asn Lys  Thr Arg Trp Thr Leu  Lys Asn Leu Asn Phe  Ser Thr Arg 
    1010                 1015                 1020             


Tyr Lys  Phe Tyr Phe Tyr Ala  Gln Thr Ser Ala Gly  Ser Gly Ser 
    1025                 1030                 1035             


Gln Ile  Thr Glu Glu Ala Val  Thr Thr Val Asp Glu  Ala Gly Ile 
    1040                 1045                 1050             


Leu Pro  Pro Asp Val Gly Ala  Gly Lys Val Gln Ala  Val Asn Pro 
    1055                 1060                 1065             


Arg Ile  Ser Asn Leu Thr Ala  Ala Ala Ala Glu Thr  Tyr Ala Asn 
    1070                 1075                 1080             


Ile Ser  Trp Glu Tyr Glu Gly  Pro Glu His Val Asn  Phe Tyr Val 
    1085                 1090                 1095             


Glu Tyr  Gly Val Ala Gly Ser  Lys Glu Glu Trp Arg  Lys Glu Ile 
    1100                 1105                 1110             


Val Asn  Gly Ser Arg Ser Phe  Phe Gly Leu Lys Gly  Leu Met Pro 
    1115                 1120                 1125             


Gly Thr  Ala Tyr Lys Val Arg  Val Gly Ala Val Gly  Asp Ser Gly 
    1130                 1135                 1140             


Phe Val  Ser Ser Glu Asp Val  Phe Glu Thr Gly Pro  Ala Met Ala 
    1145                 1150                 1155             


Ser Arg  Gln Val Asp Ile Ala  Thr Gln Gly Trp Phe  Ile Gly Leu 
    1160                 1165                 1170             


Met Cys  Ala Val Ala Leu Leu  Ile Leu Ile Leu Leu  Ile Val Cys 
    1175                 1180                 1185             


Phe Ile  Arg Arg Asn Lys Gly  Gly Lys Tyr Pro Val  Lys Glu Lys 
    1190                 1195                 1200             


Glu Asp  Ala His Ala Asp Pro  Glu Ile Gln Pro Met  Lys Glu Asp 
    1205                 1210                 1215             


Asp Gly  Thr Phe Gly Glu Tyr  Ser Asp Ala Glu Asp  His Lys Pro 
    1220                 1225                 1230             


Leu Lys  Lys Gly Ser Arg Thr  Pro Ser Asp Arg Thr  Val Lys Lys 
    1235                 1240                 1245             


Glu Asp  Ser Asp Asp Ser Leu  Val Asp Tyr Gly Glu  Gly Val Asn 
    1250                 1255                 1260             


Gly Gln  Phe Asn Glu Asp Gly  Ser Phe Ile Gly Gln  Tyr Ser Gly 
    1265                 1270                 1275             


Lys Lys  Glu Lys Glu Pro Ala  Glu Gly Asn Glu Ser  Ser Glu Ala 
    1280                 1285                 1290             


Pro Ser  Pro Val Asn Ala Met  Asn Ser Phe Val 
    1295                 1300                 


<210>  9507
<211>  190
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9507

Xaa Gly Ile Leu Pro Pro Asp Val Gly Ala Gly Lys Val Gln Ala Val 
1               5                   10                  15      


Asn Pro Arg Ile Ser Asn Leu Thr Ala Ala Ala Ala Glu Thr Tyr Ala 
            20                  25                  30          


Asn Ile Ser Trp Glu Tyr Glu Gly Pro Glu His Val Asn Phe Tyr Val 
        35                  40                  45              


Glu Tyr Gly Val Ala Gly Thr Met Ala Ser Arg Gln Val Asp Ile Ala 
    50                  55                  60                  


Thr Gln Gly Trp Phe Ile Gly Leu Met Cys Ala Val Ala Leu Leu Ile 
65                  70                  75                  80  


Leu Ile Leu Leu Ile Val Cys Phe Ile Arg Arg Asn Lys Gly Gly Lys 
                85                  90                  95      


Tyr Pro Val Lys Glu Lys Glu Asp Ala His Ala Asp Pro Glu Ile Gln 
            100                 105                 110         


Pro Met Lys Glu Asp Asp Gly Thr Phe Gly Glu Tyr Ser Asp Ala Glu 
        115                 120                 125             


Asp His Lys Pro Leu Lys Lys Gly Ser Arg Thr Pro Ser Asp Arg Thr 
    130                 135                 140                 


Val Lys Lys Glu Asp Ser Asp Asp Ser Leu Val Asp Tyr Gly Glu Gly 
145                 150                 155                 160 


Val Asn Gly Gln Phe Asn Glu Asp Gly Ser Phe Ile Gly Gln Tyr Ser 
                165                 170                 175     


Gly Lys Lys Glu Lys Glu Pro Ala Glu Gly Asn Glu Ser Ser 
            180                 185                 190 


<210>  9508
<211>  296
<212>  PRT
<213>  Homo Sapiens

<400>  9508

Met Glu Ile Tyr Ser Pro Asp Met Ser Glu Val Ala Ala Glu Arg Ser 
1               5                   10                  15      


Ser Ser Pro Ser Thr Gln Leu Ser Ala Asp Pro Ser Leu Asp Gly Leu 
            20                  25                  30          


Pro Ala Ala Glu Asp Met Pro Glu Pro Gln Thr Glu Asp Gly Arg Thr 
        35                  40                  45              


Pro Gly Leu Val Gly Leu Ala Val Pro Cys Cys Ala Cys Leu Glu Ala 
    50                  55                  60                  


Glu Arg Leu Arg Gly Cys Leu Asn Ser Glu Lys Ile Cys Ile Val Pro 
65                  70                  75                  80  


Ile Leu Ala Cys Leu Val Ser Leu Cys Leu Cys Ile Ala Gly Leu Lys 
                85                  90                  95      


Trp Val Phe Val Asp Lys Ile Phe Glu Tyr Asp Ser Pro Thr His Leu 
            100                 105                 110         


Asp Pro Gly Gly Leu Gly Gln Asp Pro Ile Ile Ser Leu Asp Ala Thr 
        115                 120                 125             


Ala Ala Ser Ala Val Trp Val Ser Ser Glu Ala Tyr Thr Ser Pro Val 
    130                 135                 140                 


Ser Arg Ala Gln Ser Glu Ser Glu Val Gln Val Thr Val Gln Gly Asp 
145                 150                 155                 160 


Lys Ala Val Val Ser Phe Glu Pro Ser Ala Ala Pro Thr Pro Lys Asn 
                165                 170                 175     


Arg Ile Phe Ala Phe Ser Phe Leu Pro Ser Thr Ala Pro Ser Phe Pro 
            180                 185                 190         


Ser Pro Thr Arg Asn Pro Glu Val Arg Thr Pro Lys Ser Ala Thr Gln 
        195                 200                 205             


Pro Gln Thr Thr Glu Thr Asn Leu Gln Thr Ala Pro Lys Leu Ser Thr 
    210                 215                 220                 


Ser Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala Glu Lys 
225                 230                 235                 240 


Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met Val Lys Asp 
                245                 250                 255     


Leu Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro Asn Glu Phe Thr 
            260                 265                 270         


Gly Asp Arg Cys Gln Asn Tyr Val Met Ala Ser Phe Tyr Ser Thr Ser 
        275                 280                 285             


Thr Pro Phe Leu Ser Leu Pro Glu 
    290                 295     


<210>  9509
<211>  590
<212>  PRT
<213>  Homo Sapiens

<400>  9509

Met Gly Lys Gly Arg Ala Gly Arg Val Gly Thr Thr Ala Leu Pro Pro 
1               5                   10                  15      


Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala Ala Gly Ser Lys Leu 
            20                  25                  30          


Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser Ser Leu Arg Phe Lys 
        35                  40                  45              


Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys Asn Lys Pro Gln Asn 
    50                  55                  60                  


Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu Leu Arg Ile Asn Lys 
65                  70                  75                  80  


Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys Lys Val Ile Ser Lys 
                85                  90                  95      


Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr Ile Val Glu Ser Asn 
            100                 105                 110         


Ala Thr Ser Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala 
        115                 120                 125             


Glu Lys Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met Val 
    130                 135                 140                 


Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro Asn Glu 
145                 150                 155                 160 


Phe Thr Gly Asp Arg Cys Gln Asn Tyr Val Met Ala Ser Phe Tyr Lys 
                165                 170                 175     


His Leu Gly Ile Glu Phe Met Glu Ala Glu Glu Leu Tyr Gln Lys Arg 
            180                 185                 190         


Val Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val Gly Ile 
        195                 200                 205             


Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys Leu 
    210                 215                 220                 


His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn Met Met 
225                 230                 235                 240 


Asn Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu Asn Val 
                245                 250                 255     


Gln Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu His 
            260                 265                 270         


Ile Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr Thr 
        275                 280                 285             


Ser Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser His Ser 
    290                 295                 300                 


Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His Ser Val 
305                 310                 315                 320 


Ile Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr Gly 
                325                 330                 335     


Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys Asn 
            340                 345                 350         


Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp Ser 
        355                 360                 365             


Pro His Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala Arg Met 
    370                 375                 380                 


Ser Pro Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro Pro Ser 
385                 390                 395                 400 


Glu Met Ser Pro Pro Val Ser Ser Met Thr Val Ser Met Pro Ser Met 
                405                 410                 415     


Ala Val Ser Pro Phe Met Glu Glu Glu Arg Pro Leu Leu Leu Val Thr 
            420                 425                 430         


Pro Pro Arg Leu Arg Glu Lys Lys Phe Asp His His Pro Gln Gln Phe 
        435                 440                 445             


Ser Ser Phe His His Asn Pro Ala His Asp Ser Asn Ser Leu Pro Ala 
    450                 455                 460                 


Ser Pro Leu Arg Ile Val Glu Asp Glu Glu Tyr Glu Thr Thr Gln Glu 
465                 470                 475                 480 


Tyr Glu Pro Ala Gln Glu Pro Val Lys Lys Leu Ala Asn Ser Arg Arg 
                485                 490                 495     


Ala Lys Arg Thr Lys Pro Asn Gly His Ile Ala Asn Arg Leu Glu Val 
            500                 505                 510         


Asp Ser Asn Thr Ser Ser Gln Ser Ser Asn Ser Glu Ser Glu Thr Glu 
        515                 520                 525             


Asp Glu Arg Val Gly Glu Asp Thr Pro Phe Leu Gly Ile Gln Asn Pro 
    530                 535                 540                 


Leu Ala Ala Ser Leu Glu Ala Thr Pro Ala Phe Arg Leu Ala Asp Ser 
545                 550                 555                 560 


Arg Thr Asn Pro Ala Gly Arg Phe Ser Thr Gln Glu Glu Ile Gln Ala 
                565                 570                 575     


Arg Leu Ser Ser Val Ile Ala Asn Gln Asp Pro Ile Ala Val 
            580                 585                 590 


<210>  9510
<211>  481
<212>  PRT
<213>  Homo Sapiens

<400>  9510

Met Gly Lys Gly Arg Ala Gly Arg Val Gly Thr Thr Ala Leu Pro Pro 
1               5                   10                  15      


Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala Ala Gly Ser Lys Leu 
            20                  25                  30          


Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser Ser Leu Arg Phe Lys 
        35                  40                  45              


Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys Asn Lys Pro Gln Asn 
    50                  55                  60                  


Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu Leu Arg Ile Asn Lys 
65                  70                  75                  80  


Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys Lys Val Ile Ser Lys 
                85                  90                  95      


Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr Ile Val Glu Ser Asn 
            100                 105                 110         


Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu Gly Ala Tyr Val Ser 
        115                 120                 125             


Ser Ala Thr Ser Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys 
    130                 135                 140                 


Ala Glu Lys Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met 
145                 150                 155                 160 


Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro Asn 
                165                 170                 175     


Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr Val Met Ala Ser Phe Tyr 
            180                 185                 190         


Lys His Leu Gly Ile Glu Phe Met Glu Ala Glu Glu Leu Tyr Gln Lys 
        195                 200                 205             


Arg Val Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val Gly 
    210                 215                 220                 


Ile Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys 
225                 230                 235                 240 


Leu His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn Met 
                245                 250                 255     


Met Asn Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu Asn 
            260                 265                 270         


Val Gln Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu 
        275                 280                 285             


His Ile Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr 
    290                 295                 300                 


Thr Ser Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser His 
305                 310                 315                 320 


Ser Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His Ser 
                325                 330                 335     


Val Ile Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr 
            340                 345                 350         


Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys 
        355                 360                 365             


Asn Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp 
    370                 375                 380                 


Ser Pro His Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala Arg 
385                 390                 395                 400 


Met Ser Pro Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro Pro 
                405                 410                 415     


Ser Glu Met Ser Pro Pro Val Ser Ser Met Thr Val Ser Met Pro Ser 
            420                 425                 430         


Met Ala Val Ser Pro Phe Met Glu Glu Glu Arg Pro Leu Leu Leu Val 
        435                 440                 445             


Thr Pro Pro Arg Leu Arg Glu Lys Lys Phe Asp His His Pro Gln Gln 
    450                 455                 460                 


Phe Ser Ser Phe His His Asn Pro Ala His Asp Ser Asn Ser Leu Pro 
465                 470                 475                 480 


Ala 
    


<210>  9511
<211>  193
<212>  PRT
<213>  Homo Sapiens

<400>  9511

Met Lys Lys Arg Asn Glu Met Ile Phe Leu Ala Thr Leu Lys Asn Lys 
1               5                   10                  15      


Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala Ala 
            20                  25                  30          


Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser Ser 
        35                  40                  45              


Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys Asn 
    50                  55                  60                  


Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu Leu 
65                  70                  75                  80  


Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys Lys 
                85                  90                  95      


Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr Ile 
            100                 105                 110         


Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu Gly 
        115                 120                 125             


Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr Glu 
    130                 135                 140                 


Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr Ser 
145                 150                 155                 160 


His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn Gly 
                165                 170                 175     


Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu 
            180                 185                 190         


Cys 
    


<210>  9512
<211>  135
<212>  PRT
<213>  Homo Sapiens

<400>  9512

Met Gln Ile Pro Lys His Ile Ser Ile Glu Asp Ile Thr Ala Thr Ser 
1               5                   10                  15      


Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala Glu Lys Glu 
            20                  25                  30          


Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met Val Lys Asp Leu 
        35                  40                  45              


Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly 
    50                  55                  60                  


Asp Arg Cys Gln Asn Tyr Val Met Ala Ser Phe Tyr Lys Ala Glu Glu 
65                  70                  75                  80  


Leu Tyr Gln Lys Arg Val Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu 
                85                  90                  95      


Leu Val Val Gly Ile Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys 
            100                 105                 110         


Gln Arg Lys Lys Leu His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu 
        115                 120                 125             


Arg Asn Asn Met Met Asn Ile 
    130                 135 


<210>  9513
<211>  101
<212>  PRT
<213>  Homo Sapiens

<400>  9513

Met Gln Ile Pro Lys His Ile Ser Ile Glu Asp Ile Thr Ala Thr Ser 
1               5                   10                  15      


Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala Glu Lys Glu 
            20                  25                  30          


Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met Val Lys Asp Leu 
        35                  40                  45              


Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly 
    50                  55                  60                  


Asp Arg Cys Gln Asn Tyr Val Met Ala Ser Phe Tyr Lys His Leu Gly 
65                  70                  75                  80  


Ile Glu Phe Met Glu Ala Glu Glu Leu Tyr Gln Lys Arg Val Leu Thr 
                85                  90                  95      


Ile Thr Gly Ile Cys 
            100     


<210>  9514
<211>  129
<212>  PRT
<213>  Homo Sapiens

<400>  9514

Met Gln Ile Pro Lys His Ile Ser Ile Glu Asp Ile Thr Ala Thr Ser 
1               5                   10                  15      


Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala Glu Lys Glu 
            20                  25                  30          


Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met Val Lys Asp Leu 
        35                  40                  45              


Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Gln Pro Gly Phe Thr Gly 
    50                  55                  60                  


Ala Arg Cys Thr Glu Asn Val Pro Met Lys Val Gln Asn Gln Glu Lys 
65                  70                  75                  80  


Ala Glu Glu Leu Tyr Gln Lys Arg Val Leu Thr Ile Thr Gly Ile Cys 
                85                  90                  95      


Ile Ala Leu Leu Val Val Gly Ile Met Cys Val Val Ala Tyr Cys Lys 
            100                 105                 110         


Thr Lys Lys Gln Arg Lys Lys Leu His Asp Arg Leu Arg Gln Ser Leu 
        115                 120                 125             


Arg 
    


<210>  9515
<211>  308
<212>  PRT
<213>  Homo Sapiens

<400>  9515

Met Gln Ile Pro Lys His Ile Ser Ile Glu Asp Ile Thr Ala Thr Ser 
1               5                   10                  15      


Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala Glu Lys Glu 
            20                  25                  30          


Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met Val Lys Asp Leu 
        35                  40                  45              


Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Gln Pro Gly Phe Thr Gly 
    50                  55                  60                  


Ala Arg Cys Thr Glu Asn Val Pro Met Lys Val Gln Asn Gln Glu Lys 
65                  70                  75                  80  


Ala Glu Glu Leu Tyr Gln Lys Arg Val Leu Thr Ile Thr Gly Ile Cys 
                85                  90                  95      


Ile Ala Leu Leu Val Val Gly Ile Met Cys Val Val Ala Tyr Cys Lys 
            100                 105                 110         


Thr Lys Lys Gln Arg Lys Lys Leu His Asp Arg Leu Arg Gln Ser Leu 
        115                 120                 125             


Arg Ser Glu Arg Asn Asn Met Met Asn Ile Ala Asn Gly Pro His His 
    130                 135                 140                 


Pro Asn Pro Pro Pro Glu Asn Val Gln Leu Val Asn Gln Tyr Val Ser 
145                 150                 155                 160 


Lys Asn Val Ile Ser Ser Glu His Ile Val Glu Arg Glu Ala Glu Thr 
                165                 170                 175     


Ser Phe Ser Thr Ser His Tyr Thr Ser Thr Ala His His Ser Thr Thr 
            180                 185                 190         


Val Thr Gln Thr Pro Ser His Ser Trp Ser Asn Gly His Thr Glu Ser 
        195                 200                 205             


Ile Leu Ser Glu Ser His Ser Val Ile Val Met Ser Ser Val Glu Asn 
    210                 215                 220                 


Ser Arg His Ser Ser Pro Thr Gly Gly Pro Arg Gly Arg Leu Asn Gly 
225                 230                 235                 240 


Thr Gly Gly Pro Arg Glu Cys Asn Ser Phe Leu Arg His Ala Arg Glu 
                245                 250                 255     


Thr Pro Asp Ser Tyr Arg Asp Ser Pro His Ser Glu Arg His Asn Leu 
            260                 265                 270         


Ile Ala Glu Leu Arg Arg Asn Lys Ala His Arg Ser Lys Cys Met Gln 
        275                 280                 285             


Ile Gln Leu Ser Ala Thr His Leu Arg Ser Ser Ser Ile Pro His Leu 
    290                 295                 300                 


Gly Phe Ile Leu 
305             


<210>  9516
<211>  254
<212>  PRT
<213>  Homo Sapiens

<400>  9516

Met Arg Trp Arg Arg Ala Pro Arg Arg Ser Gly Arg Pro Gly Pro Arg 
1               5                   10                  15      


Ala Gln Arg Pro Gly Ser Ala Ala Arg Ser Ser Pro Pro Leu Pro Leu 
            20                  25                  30          


Leu Pro Leu Leu Leu Leu Leu Gly Thr Ala Ala Leu Ala Pro Gly Ala 
        35                  40                  45              


Ala Ala Gly Asn Glu Ala Ala Pro Ala Gly Ala Ser Val Cys Tyr Ser 
    50                  55                  60                  


Ser Pro Pro Ser Val Gly Ser Val Gln Glu Leu Ala Gln Arg Ala Ala 
65                  70                  75                  80  


Val Val Ile Glu Gly Lys Val His Pro Gln Arg Arg Gln Gln Gly Ala 
                85                  90                  95      


Leu Asp Arg Lys Ala Ala Ala Ala Ala Gly Glu Ala Gly Ala Trp Gly 
            100                 105                 110         


Gly Asp Arg Glu Pro Pro Ala Ala Gly Pro Arg Ala Leu Gly Pro Pro 
        115                 120                 125             


Ala Glu Glu Pro Leu Leu Ala Ala Asn Gly Thr Val Pro Ser Trp Pro 
    130                 135                 140                 


Thr Ala Pro Val Pro Ser Ala Gly Glu Pro Gly Glu Glu Ala Pro Tyr 
145                 150                 155                 160 


Leu Val Lys Val His Gln Val Trp Ala Val Lys Ala Gly Gly Leu Lys 
                165                 170                 175     


Lys Asp Ser Leu Leu Thr Val Arg Leu Gly Thr Trp Gly His Pro Ala 
            180                 185                 190         


Phe Pro Ser Cys Gly Arg Leu Lys Glu Asp Ser Arg Tyr Ile Phe Phe 
        195                 200                 205             


Met Glu Pro Asp Ala Asn Ser Thr Ser Arg Ala Pro Ala Ala Phe Arg 
    210                 215                 220                 


Ala Ser Phe Pro Pro Leu Glu Thr Gly Arg Asn Leu Lys Lys Glu Val 
225                 230                 235                 240 


Ser Arg Val Leu Cys Lys Arg Cys Ala Phe Pro Pro Gly Leu 
                245                 250                 


<210>  9517
<211>  422
<212>  PRT
<213>  Homo Sapiens

<400>  9517

Met Arg Trp Arg Arg Ala Pro Arg Arg Ser Gly Arg Pro Gly Pro Arg 
1               5                   10                  15      


Ala Gln Arg Pro Gly Ser Ala Ala Arg Ser Ser Pro Pro Leu Pro Leu 
            20                  25                  30          


Leu Pro Leu Leu Leu Leu Leu Gly Thr Ala Ala Leu Ala Pro Gly Ala 
        35                  40                  45              


Ala Ala Gly Asn Glu Ala Ala Pro Ala Gly Ala Ser Val Cys Tyr Ser 
    50                  55                  60                  


Ser Pro Pro Ser Val Gly Ser Val Gln Glu Leu Ala Gln Arg Ala Ala 
65                  70                  75                  80  


Val Val Ile Glu Gly Lys Val His Pro Gln Arg Arg Gln Gln Gly Ala 
                85                  90                  95      


Leu Asp Arg Lys Ala Ala Ala Ala Ala Gly Glu Ala Gly Ala Trp Gly 
            100                 105                 110         


Gly Asp Arg Glu Pro Pro Ala Ala Gly Pro Arg Ala Leu Gly Pro Pro 
        115                 120                 125             


Ala Glu Glu Pro Leu Leu Ala Ala Asn Gly Thr Val Pro Ser Trp Pro 
    130                 135                 140                 


Thr Ala Pro Val Pro Ser Ala Gly Glu Pro Gly Glu Glu Ala Pro Tyr 
145                 150                 155                 160 


Leu Val Lys Val His Gln Val Trp Ala Val Lys Ala Gly Gly Leu Lys 
                165                 170                 175     


Lys Asp Ser Leu Leu Thr Val Arg Leu Gly Thr Trp Gly His Pro Ala 
            180                 185                 190         


Phe Pro Ser Cys Gly Arg Leu Lys Glu Asp Ser Arg Tyr Ile Phe Phe 
        195                 200                 205             


Met Glu Pro Asp Ala Asn Ser Thr Ser Arg Ala Pro Ala Ala Phe Arg 
    210                 215                 220                 


Ala Ser Phe Pro Pro Leu Glu Thr Gly Arg Asn Leu Lys Lys Glu Val 
225                 230                 235                 240 


Ser Arg Val Leu Cys Lys Arg Cys Ala Leu Pro Pro Arg Leu Lys Glu 
                245                 250                 255     


Met Lys Ser Gln Glu Ser Ala Ala Gly Ser Lys Leu Val Leu Arg Cys 
            260                 265                 270         


Glu Thr Ser Ser Glu Tyr Ser Ser Leu Arg Phe Lys Trp Phe Lys Asn 
        275                 280                 285             


Gly Asn Glu Leu Asn Arg Lys Asn Lys Pro Gln Asn Ile Lys Ile Gln 
    290                 295                 300                 


Lys Lys Pro Gly Lys Ser Glu Leu Arg Ile Asn Lys Ala Ser Leu Ala 
305                 310                 315                 320 


Asp Ser Gly Glu Tyr Met Cys Lys Val Ile Ser Lys Leu Gly Asn Asp 
                325                 330                 335     


Ser Ala Ser Ala Asn Ile Thr Ile Val Glu Ser Asn Ala Thr Ser Thr 
            340                 345                 350         


Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys 
        355                 360                 365             


Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser 
    370                 375                 380                 


Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp 
385                 390                 395                 400 


Arg Cys Gln Asn Tyr Val Met Ala Ser Phe Tyr Ser Thr Ser Thr Pro 
                405                 410                 415     


Phe Leu Ser Leu Pro Glu 
            420         


<210>  9518
<211>  637
<212>  PRT
<213>  Homo Sapiens

<400>  9518

Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 


Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 


Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     


Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
    210                 215                 220                 


Val Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Lys Arg Val 
225                 230                 235                 240 


Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val Gly Ile Met 
                245                 250                 255     


Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys Leu His 
            260                 265                 270         


Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn Met Met Asn 
        275                 280                 285             


Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu Asn Val Gln 
    290                 295                 300                 


Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu His Ile 
305                 310                 315                 320 


Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr Thr Ser 
                325                 330                 335     


Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser His Ser Trp 
            340                 345                 350         


Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His Ser Val Ile 
        355                 360                 365             


Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr Gly Gly 
    370                 375                 380                 


Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys Asn Ser 
385                 390                 395                 400 


Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp Ser Pro 
                405                 410                 415     


His Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala Arg Met Ser 
            420                 425                 430         


Pro Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro Pro Ser Glu 
        435                 440                 445             


Met Ser Pro Pro Val Ser Ser Met Thr Val Ser Met Pro Ser Met Ala 
    450                 455                 460                 


Val Ser Pro Phe Met Glu Glu Glu Arg Pro Leu Leu Leu Val Thr Pro 
465                 470                 475                 480 


Pro Arg Leu Arg Glu Lys Lys Phe Asp His His Pro Gln Gln Phe Ser 
                485                 490                 495     


Ser Phe His His Asn Pro Ala His Asp Ser Asn Ser Leu Pro Ala Ser 
            500                 505                 510         


Pro Leu Arg Ile Val Glu Asp Glu Glu Tyr Glu Thr Thr Gln Glu Tyr 
        515                 520                 525             


Glu Pro Ala Gln Glu Pro Val Lys Lys Leu Ala Asn Ser Arg Arg Ala 
    530                 535                 540                 


Lys Arg Thr Lys Pro Asn Gly His Ile Ala Asn Arg Leu Glu Val Asp 
545                 550                 555                 560 


Ser Asn Thr Ser Ser Gln Ser Ser Asn Ser Glu Ser Glu Thr Glu Asp 
                565                 570                 575     


Glu Arg Val Gly Glu Asp Thr Pro Phe Leu Gly Ile Gln Asn Pro Leu 
            580                 585                 590         


Ala Ala Ser Leu Glu Ala Thr Pro Ala Phe Arg Leu Ala Asp Ser Arg 
        595                 600                 605             


Thr Asn Pro Ala Gly Arg Phe Ser Thr Gln Glu Glu Ile Gln Ala Arg 
    610                 615                 620                 


Leu Ser Ser Val Ile Ala Asn Gln Asp Pro Ile Ala Val 
625                 630                 635         


<210>  9519
<211>  420
<212>  PRT
<213>  Homo Sapiens

<400>  9519

Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 


Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 


Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     


Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
    210                 215                 220                 


Val Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Lys Arg Val 
225                 230                 235                 240 


Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val Gly Ile Met 
                245                 250                 255     


Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys Leu His 
            260                 265                 270         


Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn Met Met Asn 
        275                 280                 285             


Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu Asn Val Gln 
    290                 295                 300                 


Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu His Ile 
305                 310                 315                 320 


Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr Thr Ser 
                325                 330                 335     


Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser His Ser Trp 
            340                 345                 350         


Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His Ser Val Ile 
        355                 360                 365             


Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr Gly Gly 
    370                 375                 380                 


Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys Asn Ser 
385                 390                 395                 400 


Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp Ser Pro 
                405                 410                 415     


His Ser Glu Arg 
            420 


<210>  9520
<211>  645
<212>  PRT
<213>  Homo Sapiens

<400>  9520

Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 


Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 


Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     


Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
    210                 215                 220                 


Val Met Ala Ser Phe Tyr Lys His Leu Gly Ile Glu Phe Met Glu Ala 
225                 230                 235                 240 


Glu Glu Leu Tyr Gln Lys Arg Val Leu Thr Ile Thr Gly Ile Cys Ile 
                245                 250                 255     


Ala Leu Leu Val Val Gly Ile Met Cys Val Val Ala Tyr Cys Lys Thr 
            260                 265                 270         


Lys Lys Gln Arg Lys Lys Leu His Asp Arg Leu Arg Gln Ser Leu Arg 
        275                 280                 285             


Ser Glu Arg Asn Asn Met Met Asn Ile Ala Asn Gly Pro His His Pro 
    290                 295                 300                 


Asn Pro Pro Pro Glu Asn Val Gln Leu Val Asn Gln Tyr Val Ser Lys 
305                 310                 315                 320 


Asn Val Ile Ser Ser Glu His Ile Val Glu Arg Glu Ala Glu Thr Ser 
                325                 330                 335     


Phe Ser Thr Ser His Tyr Thr Ser Thr Ala His His Ser Thr Thr Val 
            340                 345                 350         


Thr Gln Thr Pro Ser His Ser Trp Ser Asn Gly His Thr Glu Ser Ile 
        355                 360                 365             


Leu Ser Glu Ser His Ser Val Ile Val Met Ser Ser Val Glu Asn Ser 
    370                 375                 380                 


Arg His Ser Ser Pro Thr Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr 
385                 390                 395                 400 


Gly Gly Pro Arg Glu Cys Asn Ser Phe Leu Arg His Ala Arg Glu Thr 
                405                 410                 415     


Pro Asp Ser Tyr Arg Asp Ser Pro His Ser Glu Arg Tyr Val Ser Ala 
            420                 425                 430         


Met Thr Thr Pro Ala Arg Met Ser Pro Val Asp Phe His Thr Pro Ser 
        435                 440                 445             


Ser Pro Lys Ser Pro Pro Ser Glu Met Ser Pro Pro Val Ser Ser Met 
    450                 455                 460                 


Thr Val Ser Met Pro Ser Met Ala Val Ser Pro Phe Met Glu Glu Glu 
465                 470                 475                 480 


Arg Pro Leu Leu Leu Val Thr Pro Pro Arg Leu Arg Glu Lys Lys Phe 
                485                 490                 495     


Asp His His Pro Gln Gln Phe Ser Ser Phe His His Asn Pro Ala His 
            500                 505                 510         


Asp Ser Asn Ser Leu Pro Ala Ser Pro Leu Arg Ile Val Glu Asp Glu 
        515                 520                 525             


Glu Tyr Glu Thr Thr Gln Glu Tyr Glu Pro Ala Gln Glu Pro Val Lys 
    530                 535                 540                 


Lys Leu Ala Asn Ser Arg Arg Ala Lys Arg Thr Lys Pro Asn Gly His 
545                 550                 555                 560 


Ile Ala Asn Arg Leu Glu Val Asp Ser Asn Thr Ser Ser Gln Ser Ser 
                565                 570                 575     


Asn Ser Glu Ser Glu Thr Glu Asp Glu Arg Val Gly Glu Asp Thr Pro 
            580                 585                 590         


Phe Leu Gly Ile Gln Asn Pro Leu Ala Ala Ser Leu Glu Ala Thr Pro 
        595                 600                 605             


Ala Phe Arg Leu Ala Asp Ser Arg Thr Asn Pro Ala Gly Arg Phe Ser 
    610                 615                 620                 


Thr Gln Glu Glu Ile Gln Ala Arg Leu Ser Ser Val Ile Ala Asn Gln 
625                 630                 635                 640 


Asp Pro Ile Ala Val 
                645 


<210>  9521
<211>  640
<212>  PRT
<213>  Homo Sapiens

<400>  9521

Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 


Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 


Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     


Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             


Leu Cys Lys Cys Gln Pro Gly Phe Thr Gly Ala Arg Cys Thr Glu Asn 
    210                 215                 220                 


Val Pro Met Lys Val Gln Asn Gln Glu Lys Ala Glu Glu Leu Tyr Gln 
225                 230                 235                 240 


Lys Arg Val Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val 
                245                 250                 255     


Gly Ile Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys 
            260                 265                 270         


Lys Leu His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn 
        275                 280                 285             


Met Met Asn Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu 
    290                 295                 300                 


Asn Val Gln Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser 
305                 310                 315                 320 


Glu His Ile Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His 
                325                 330                 335     


Tyr Thr Ser Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser 
            340                 345                 350         


His Ser Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His 
        355                 360                 365             


Ser Val Ile Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro 
    370                 375                 380                 


Thr Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu 
385                 390                 395                 400 


Cys Asn Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg 
                405                 410                 415     


Asp Ser Pro His Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala 
            420                 425                 430         


Arg Met Ser Pro Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro 
        435                 440                 445             


Pro Ser Glu Met Ser Pro Pro Val Ser Ser Met Thr Val Ser Met Pro 
    450                 455                 460                 


Ser Met Ala Val Ser Pro Phe Met Glu Glu Glu Arg Pro Leu Leu Leu 
465                 470                 475                 480 


Val Thr Pro Pro Arg Leu Arg Glu Lys Lys Phe Asp His His Pro Gln 
                485                 490                 495     


Gln Phe Ser Ser Phe His His Asn Pro Ala His Asp Ser Asn Ser Leu 
            500                 505                 510         


Pro Ala Ser Pro Leu Arg Ile Val Glu Asp Glu Glu Tyr Glu Thr Thr 
        515                 520                 525             


Gln Glu Tyr Glu Pro Ala Gln Glu Pro Val Lys Lys Leu Ala Asn Ser 
    530                 535                 540                 


Arg Arg Ala Lys Arg Thr Lys Pro Asn Gly His Ile Ala Asn Arg Leu 
545                 550                 555                 560 


Glu Val Asp Ser Asn Thr Ser Ser Gln Ser Ser Asn Ser Glu Ser Glu 
                565                 570                 575     


Thr Glu Asp Glu Arg Val Gly Glu Asp Thr Pro Phe Leu Gly Ile Gln 
            580                 585                 590         


Asn Pro Leu Ala Ala Ser Leu Glu Ala Thr Pro Ala Phe Arg Leu Ala 
        595                 600                 605             


Asp Ser Arg Thr Asn Pro Ala Gly Arg Phe Ser Thr Gln Glu Glu Ile 
    610                 615                 620                 


Gln Ala Arg Leu Ser Ser Val Ile Ala Asn Gln Asp Pro Ile Ala Val 
625                 630                 635                 640 


<210>  9522
<211>  462
<212>  PRT
<213>  Homo Sapiens

<400>  9522

Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 


Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 


Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     


Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             


Leu Cys Lys Cys Gln Pro Gly Phe Thr Gly Ala Arg Cys Thr Glu Asn 
    210                 215                 220                 


Val Pro Met Lys Val Gln Asn Gln Glu Lys Ala Glu Glu Leu Tyr Gln 
225                 230                 235                 240 


Lys Arg Val Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val 
                245                 250                 255     


Gly Ile Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys 
            260                 265                 270         


Lys Leu His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn 
        275                 280                 285             


Met Met Asn Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu 
    290                 295                 300                 


Asn Val Gln Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser 
305                 310                 315                 320 


Glu His Ile Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His 
                325                 330                 335     


Tyr Thr Ser Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser 
            340                 345                 350         


His Ser Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His 
        355                 360                 365             


Ser Val Ile Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro 
    370                 375                 380                 


Thr Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu 
385                 390                 395                 400 


Cys Asn Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg 
                405                 410                 415     


Asp Ser Pro His Ser Glu Arg His Asn Leu Ile Ala Glu Leu Arg Arg 
            420                 425                 430         


Asn Lys Ala His Arg Ser Lys Cys Met Gln Ile Gln Leu Ser Ala Thr 
        435                 440                 445             


His Leu Arg Ser Ser Ser Ile Pro His Leu Gly Phe Ile Leu 
    450                 455                 460         


<210>  9523
<211>  196
<212>  PRT
<213>  Homo Sapiens

<400>  9523

Pro Gln Thr Glu Asp Gly Arg Thr Pro Gly Leu Val Gly Leu Ala Val 
1               5                   10                  15      


Pro Cys Cys Ala Cys Leu Glu Ala Glu Arg Leu Arg Gly Cys Leu Asn 
            20                  25                  30          


Ser Glu Lys Ile Cys Ile Val Pro Ile Leu Ala Cys Leu Val Ser Leu 
        35                  40                  45              


Cys Leu Cys Ile Ala Gly Leu Lys Trp Val Phe Val Asp Lys Ile Phe 
    50                  55                  60                  


Glu Tyr Asp Ser Pro Thr His Leu Asp Pro Gly Gly Leu Gly Gln Asp 
65                  70                  75                  80  


Pro Ile Ile Ser Leu Asp Ala Thr Ala Ala Ser Ala Val Trp Val Ser 
                85                  90                  95      


Ser Glu Ala Tyr Thr Ser Pro Val Ser Arg Ala Gln Ser Glu Ser Glu 
            100                 105                 110         


Val Gln Val Thr Val Gln Gly Asp Lys Ala Val Val Ser Phe Glu Pro 
        115                 120                 125             


Ser Ala Ala Pro Thr Pro Lys Asn Arg Ile Phe Ala Phe Ser Phe Leu 
    130                 135                 140                 


Pro Ser Thr Ala Pro Ser Phe Pro Ser Pro Thr Arg Asn Pro Glu Val 
145                 150                 155                 160 


Arg Thr Pro Lys Ser Ala Thr Gln Pro Gln Thr Thr Glu Thr Asn Leu 
                165                 170                 175     


Gln Thr Ala Pro Lys Leu Cys Ala Gln Met Ser Leu Leu Val Ile Ala 
            180                 185                 190         


Ala Lys Thr Thr 
        195     


<210>  9524
<211>  713
<212>  PRT
<213>  Homo Sapiens

<400>  9524

Val Pro Ser Ala Gly Glu Pro Gly Glu Glu Ala Pro Tyr Leu Val Lys 
1               5                   10                  15      


Val His Gln Val Trp Ala Val Lys Ala Gly Gly Leu Lys Lys Asp Ser 
            20                  25                  30          


Leu Leu Thr Val Arg Leu Gly Thr Trp Gly His Pro Ala Phe Pro Ser 
        35                  40                  45              


Cys Gly Arg Leu Lys Glu Asp Ser Arg Tyr Ile Phe Phe Met Glu Pro 
    50                  55                  60                  


Asp Ala Asn Ser Thr Ser Arg Ala Pro Ala Ala Phe Arg Ala Ser Phe 
65                  70                  75                  80  


Pro Pro Leu Glu Thr Gly Arg Asn Leu Lys Lys Glu Val Ser Arg Val 
                85                  90                  95      


Leu Cys Lys Arg Cys Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser 
            100                 105                 110         


Gln Glu Ser Ala Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser 
        115                 120                 125             


Ser Glu Tyr Ser Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu 
    130                 135                 140                 


Leu Asn Arg Lys Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro 
145                 150                 155                 160 


Gly Lys Ser Glu Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly 
                165                 170                 175     


Glu Tyr Met Cys Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser 
            180                 185                 190         


Ala Asn Ile Thr Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro 
        195                 200                 205             


Ala Ser Thr Glu Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile 
    210                 215                 220                 


Ser Val Ser Thr Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser 
225                 230                 235                 240 


Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr 
                245                 250                 255     


Phe Cys Val Asn Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn 
            260                 265                 270         


Pro Ser Arg Tyr Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg 
        275                 280                 285             


Cys Gln Asn Tyr Val Met Ala Ser Phe Tyr Lys His Leu Gly Ile Glu 
    290                 295                 300                 


Phe Met Glu Ala Glu Glu Leu Tyr Gln Lys Arg Val Leu Thr Ile Thr 
305                 310                 315                 320 


Gly Ile Cys Ile Ala Leu Leu Val Val Gly Ile Met Cys Val Val Ala 
                325                 330                 335     


Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys Leu His Asp Arg Leu Arg 
            340                 345                 350         


Gln Ser Leu Arg Ser Glu Arg Asn Asn Met Met Asn Ile Ala Asn Gly 
        355                 360                 365             


Pro His His Pro Asn Pro Pro Pro Glu Asn Val Gln Leu Val Asn Gln 
    370                 375                 380                 


Tyr Val Ser Lys Asn Val Ile Ser Ser Glu His Ile Val Glu Arg Glu 
385                 390                 395                 400 


Ala Glu Thr Ser Phe Ser Thr Ser His Tyr Thr Ser Thr Ala His His 
                405                 410                 415     


Ser Thr Thr Val Thr Gln Thr Pro Ser His Ser Trp Ser Asn Gly His 
            420                 425                 430         


Thr Glu Ser Ile Leu Ser Glu Ser His Ser Val Ile Val Met Ser Ser 
        435                 440                 445             


Val Glu Asn Ser Arg His Ser Ser Pro Thr Gly Gly Pro Arg Gly Arg 
    450                 455                 460                 


Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys Asn Ser Phe Leu Arg His 
465                 470                 475                 480 


Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp Ser Pro His Ser Glu Arg 
                485                 490                 495     


Tyr Val Ser Ala Met Thr Thr Pro Ala Arg Met Ser Pro Val Asp Phe 
            500                 505                 510         


His Thr Pro Ser Ser Pro Lys Ser Pro Pro Ser Glu Met Ser Pro Pro 
        515                 520                 525             


Val Ser Ser Met Thr Val Ser Met Pro Ser Met Ala Val Ser Pro Phe 
    530                 535                 540                 


Met Glu Glu Glu Arg Pro Leu Leu Leu Val Thr Pro Pro Arg Leu Arg 
545                 550                 555                 560 


Glu Lys Lys Phe Asp His His Pro Gln Gln Phe Ser Ser Phe His His 
                565                 570                 575     


Asn Pro Ala His Asp Ser Asn Ser Leu Pro Ala Ser Pro Leu Arg Ile 
            580                 585                 590         


Val Glu Asp Glu Glu Tyr Glu Thr Thr Gln Glu Tyr Glu Pro Ala Gln 
        595                 600                 605             


Glu Pro Val Lys Lys Leu Ala Asn Ser Arg Arg Ala Lys Arg Thr Lys 
    610                 615                 620                 


Pro Asn Gly His Ile Ala Asn Arg Leu Glu Val Asp Ser Asn Thr Ser 
625                 630                 635                 640 


Ser Gln Ser Ser Asn Ser Glu Ser Glu Thr Glu Asp Glu Arg Val Gly 
                645                 650                 655     


Glu Asp Thr Pro Phe Leu Gly Ile Gln Asn Pro Leu Ala Ala Ser Leu 
            660                 665                 670         


Glu Ala Thr Pro Ala Phe Arg Leu Ala Asp Ser Arg Thr Asn Pro Ala 
        675                 680                 685             


Gly Arg Phe Ser Thr Gln Glu Glu Ile Gln Ala Arg Leu Ser Ser Val 
    690                 695                 700                 


Ile Ala Asn Gln Asp Pro Ile Ala Val 
705                 710             


<210>  9525
<211>  126
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9525

Xaa Ala Ser Ala Asn Ile Thr Ile Val Glu Ser Asn Glu Ile Ile Thr 
1               5                   10                  15      


Gly Met Pro Ala Ser Thr Glu Gly Ala Tyr Val Ser Ser Glu Ser Pro 
            20                  25                  30          


Ile Arg Ile Ser Val Ser Thr Glu Gly Ala Asn Thr Ser Ser Ser Thr 
        35                  40                  45              


Ser Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala Glu Lys 
    50                  55                  60                  


Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met Val Lys Asp 
65                  70                  75                  80  


Leu Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Gln Pro Gly Phe Thr 
                85                  90                  95      


Gly Ala Arg Cys Thr Glu Asn Val Pro Met Lys Val Gln Asn Gln Glu 
            100                 105                 110         


Ser Ala Gln Met Ser Leu Leu Val Ile Ala Ala Lys Thr Thr 
        115                 120                 125     


<210>  9526
<211>  165
<212>  PRT
<213>  Homo Sapiens

<400>  9526

Met Met Arg Cys Cys Arg Arg Arg Cys Cys Cys Arg Gln Pro Pro His 
1               5                   10                  15      


Ala Leu Arg Pro Leu Leu Leu Leu Pro Leu Val Leu Leu Pro Pro Leu 
            20                  25                  30          


Ala Ala Ala Ala Ala Gly Pro Asn Arg Cys Asp Thr Ile Tyr Gln Gly 
        35                  40                  45              


Phe Ala Glu Cys Leu Ile Arg Leu Gly Asp Ser Met Gly Arg Gly Gly 
    50                  55                  60                  


Glu Leu Glu Thr Ile Cys Arg Ser Trp Asn Asp Phe His Ala Cys Ala 
65                  70                  75                  80  


Ser Gln Val Leu Ser Gly Cys Pro Glu Glu Ala Ala Ala Val Trp Glu 
                85                  90                  95      


Ser Leu Gln Gln Glu Ala Arg Gln Ala Pro Arg Pro Asn Asn Leu His 
            100                 105                 110         


Thr Leu Cys Gly Ala Pro Val His Val Arg Glu Arg Gly Thr Gly Ser 
        115                 120                 125             


Glu Thr Asn Gln Glu Thr Leu Arg Ala Thr Ala Pro Ala Leu Pro Met 
    130                 135                 140                 


Ala Pro Ala Pro Pro Leu Leu Ala Ala Ala Leu Ala Leu Ala Tyr Leu 
145                 150                 155                 160 


Leu Arg Pro Leu Ala 
                165 


<210>  9527
<211>  87
<212>  PRT
<213>  Homo Sapiens

<400>  9527

Met Thr Ser Met Pro Val Pro Leu Arg Ser Cys Gln Ala Val Arg Arg 
1               5                   10                  15      


Arg Gln Leu Gln Cys Gly Asn His Tyr Ser Lys Lys Leu Ala Arg Pro 
            20                  25                  30          


Pro Val Arg Ile Thr Cys Thr Leu Cys Ala Val Pro Arg Cys Met Phe 
        35                  40                  45              


Gly Ser Ala Ala Gln Ala Pro Lys Pro Thr Arg Arg Arg Cys Gly Leu 
    50                  55                  60                  


Gln Arg Leu His Ser Pro Trp Pro Leu Arg Pro His Cys Trp Arg Leu 
65                  70                  75                  80  


Leu Trp Leu Trp Pro Thr Ser 
                85          


<210>  9528
<211>  88
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9528

Xaa Arg Cys Cys Arg Arg Arg Cys Cys Cys Arg Gln Pro Pro His Ala 
1               5                   10                  15      


Leu Arg Pro Leu Leu Leu Leu Pro Leu Val Leu Leu Pro Pro Leu Ala 
            20                  25                  30          


Ala Ala Ala Ala Gly Pro Asn Arg Cys Asp Thr Ile Tyr Gln Gly Phe 
        35                  40                  45              


Ala Glu Cys Leu Ile Arg Leu Gly Asp Ser Met Gly Arg Gly Gly Glu 
    50                  55                  60                  


Leu Glu Thr Ile Cys Ser Thr Val Asp Lys Glu Tyr Leu Ile Val Leu 
65                  70                  75                  80  


Arg Glu Pro Gly Gly Trp Met Ser 
                85              


<210>  9529
<211>  923
<212>  PRT
<213>  Homo Sapiens

<400>  9529

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Val Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser 
                645                 650                 655     


His Lys Thr Phe Cys His Trp Glu His Asp Asn His Val Gln Leu Lys 
            660                 665                 670         


Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly 
        675                 680                 685             


Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys 
    690                 695                 700                 


Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His 
705                 710                 715                 720 


Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly Thr Leu 
                725                 730                 735     


Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val 
            740                 745                 750         


Trp Met Ala Ile Gly His Gln Gly Asp His Trp Lys Glu Gly Arg Val 
        755                 760                 765             


Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu 
    770                 775                 780                 


Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile 
785                 790                 795                 800 


Asn Asn His Ile Ser Gln Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp 
                805                 810                 815     


Lys Lys Asn Pro Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly 
            820                 825                 830         


Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly 
        835                 840                 845             


Asn Val Leu Lys Thr Leu Asp Pro Ile Leu Ile Thr Ile Ile Ala Met 
    850                 855                 860                 


Ser Ala Leu Gly Val Leu Leu Gly Ala Val Cys Gly Val Val Leu Tyr 
865                 870                 875                 880 


Cys Ala Cys Trp His Asn Gly Met Ser Glu Arg Asn Leu Ser Ala Leu 
                885                 890                 895     


Glu Asn Tyr Asn Phe Glu Leu Val Asp Gly Val Lys Leu Lys Lys Asp 
            900                 905                 910         


Lys Leu Asn Thr Gln Ser Thr Tyr Ser Glu Ala 
        915                 920             


<210>  9530
<211>  641
<212>  PRT
<213>  Homo Sapiens

<400>  9530

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Val Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Gly Thr Ile Asn Thr Asp 
            580                 585                 590         


Gln Glu Cys Pro Cys Ala Arg Ala Leu Ala Lys Asp Ala Lys Lys Lys 
        595                 600                 605             


Lys Arg Trp Ala Asp Ser Thr His Cys Arg Cys Val Arg Ser Ile His 
    610                 615                 620                 


Gly Glu Met Trp Ser Ser Gly Lys Gly Val Cys Ser Leu Asp Ala Asn 
625                 630                 635                 640 


Leu 
    


<210>  9531
<211>  704
<212>  PRT
<213>  Homo Sapiens

<400>  9531

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Val Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Ala Glu 
    610                 615                 620                 


Thr Ile Phe Ile Pro Leu Leu Tyr His Phe Ser Ser Cys Leu Ser Trp 
625                 630                 635                 640 


Asp Gln Leu Thr Pro Val Cys Val Leu Val Thr Pro His Gly Arg Glu 
                645                 650                 655     


Leu Pro Arg Asn Arg Ser Cys Leu Ala Arg Thr Arg Ala Ser Ser Phe 
            660                 665                 670         


Pro His Val Ile Trp Ile Asp Glu Leu Phe Leu Ile Ala Thr Thr Ile 
        675                 680                 685             


Cys Asn Asn Asn Leu Ser His Phe Glu Ser Gln Arg Leu Gly Leu Ser 
    690                 695                 700                 


<210>  9532
<211>  644
<212>  PRT
<213>  Homo Sapiens

<400>  9532

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Val Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Gly Ile Lys 
                


<210>  9533
<211>  923
<212>  PRT
<213>  Homo Sapiens

<400>  9533

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Val Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser 
                645                 650                 655     


His Lys Thr Phe Cys His Trp Glu His Asp Asn His Val Gln Leu Lys 
            660                 665                 670         


Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly 
        675                 680                 685             


Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys 
    690                 695                 700                 


Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His 
705                 710                 715                 720 


Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly Thr Leu 
                725                 730                 735     


Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val 
            740                 745                 750         


Trp Met Ala Ile Gly His Gln Gly Asp His Trp Lys Glu Gly Arg Val 
        755                 760                 765             


Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu 
    770                 775                 780                 


Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile 
785                 790                 795                 800 


Asn Asn His Ile Ser Gln Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp 
                805                 810                 815     


Lys Lys Asn Pro Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly 
            820                 825                 830         


Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly 
        835                 840                 845             


Asn Val Leu Lys Thr Leu Asp Pro Ile Leu Ile Thr Ile Ile Ala Met 
    850                 855                 860                 


Ser Ala Leu Gly Val Leu Leu Gly Ala Val Cys Gly Val Val Leu Tyr 
865                 870                 875                 880 


Cys Ala Cys Trp His Asn Gly Met Ser Glu Arg Asn Leu Ser Ala Leu 
                885                 890                 895     


Glu Asn Tyr Asn Phe Glu Leu Val Asp Gly Val Lys Leu Lys Lys Asp 
            900                 905                 910         


Lys Leu Asn Thr Gln Ser Thr Tyr Ser Glu Ala 
        915                 920             


<210>  9534
<211>  609
<212>  PRT
<213>  Homo Sapiens

<400>  9534

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Val Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Gly Gly Thr Thr Val Leu 
            580                 585                 590         


Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln Ser Gly Ile 
        595                 600                 605             


Lys 
    


<210>  9535
<211>  597
<212>  PRT
<213>  Homo Sapiens

<400>  9535

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Val Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Val Arg Ala Gly Asp Trp 
    530                 535                 540                 


Glu Glu Val Ile Pro Tyr Val Leu Asp Phe Asn Gln Gly Pro Leu Ala 
545                 550                 555                 560 


Phe Ser Arg Gly Arg Ala Ser Tyr Phe Leu Pro Ala Met Thr Leu Glu 
                565                 570                 575     


Glu Val Cys Asp Gly Val Ser Lys Thr Leu Asp Ser Arg Lys Thr Gly 
            580                 585                 590         


Ile Trp His Glu Lys 
        595         


<210>  9536
<211>  906
<212>  PRT
<213>  Homo Sapiens

<400>  9536

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Val Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser 
                645                 650                 655     


His Lys Thr Phe Cys His Trp Glu His Asp Asn His Val Gln Leu Lys 
            660                 665                 670         


Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly 
        675                 680                 685             


Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys 
    690                 695                 700                 


Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His 
705                 710                 715                 720 


Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly Thr Leu 
                725                 730                 735     


Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val 
            740                 745                 750         


Trp Met Ala Ile Gly His Gln Gly Asp His Trp Lys Glu Gly Arg Val 
        755                 760                 765             


Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu 
    770                 775                 780                 


Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile 
785                 790                 795                 800 


Asn Asn His Ile Ser Gln Glu Asp Cys Ala Arg Ser Thr Pro Gly Tyr 
                805                 810                 815     


Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly Asn 
            820                 825                 830         


Val Leu Lys Thr Leu Asp Pro Ile Leu Ile Thr Ile Ile Ala Met Ser 
        835                 840                 845             


Ala Leu Gly Val Leu Leu Gly Ala Val Cys Gly Val Val Leu Tyr Cys 
    850                 855                 860                 


Ala Cys Trp His Asn Gly Met Ser Glu Arg Asn Leu Ser Ala Leu Glu 
865                 870                 875                 880 


Asn Tyr Asn Phe Glu Leu Val Asp Gly Val Lys Leu Lys Lys Asp Lys 
                885                 890                 895     


Leu Asn Thr Gln Ser Thr Tyr Ser Glu Ala 
            900                 905     


<210>  9537
<211>  735
<212>  PRT
<213>  Homo Sapiens

<400>  9537

Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe Asp Leu Glu Pro Asp 
1               5                   10                  15      


Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile 
            20                  25                  30          


Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly 
        35                  40                  45              


Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met 
    50                  55                  60                  


Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn 
65                  70                  75                  80  


Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu 
                85                  90                  95      


Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala 
            100                 105                 110         


Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn 
        115                 120                 125             


Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu Trp 
    130                 135                 140                 


Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val Thr Ala Val Gly Thr 
145                 150                 155                 160 


Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys Tyr Tyr Val Lys Thr 
                165                 170                 175     


Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp Trp Ile Thr Ile Lys 
            180                 185                 190         


Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn Thr Asn Pro Thr Asp 
        195                 200                 205             


Val Val Val Ala Val Phe Pro Lys Pro Leu Ile Thr Arg Phe Val Arg 
    210                 215                 220                 


Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser Met Arg Phe Glu Val 
225                 230                 235                 240 


Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser Gly Met Leu Gly Met 
                245                 250                 255     


Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr Ser Ser Asn Gln Gly 
            260                 265                 270         


Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu Val Thr Ser Arg Ser 
        275                 280                 285             


Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr Ile Asn Glu Trp Leu 
    290                 295                 300                 


Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg Gly Ile Ile Ile Gln 
305                 310                 315                 320 


Gly Gly Lys His Arg Glu Asn Lys Val Phe Met Arg Lys Phe Lys Ile 
                325                 330                 335     


Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met Ile Met Asp Asp Ser 
            340                 345                 350         


Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn Asn Tyr Asp Thr Pro 
        355                 360                 365             


Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg Phe Ile Arg Ile Tyr 
    370                 375                 380                 


Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu Arg Met Glu Leu Leu 
385                 390                 395                 400 


Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro Thr Thr Pro Asn Gly 
                405                 410                 415     


Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala Asn Cys His Ser Gly 
            420                 425                 430         


Thr Gly Gly Thr Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp 
        435                 440                 445             


Ser Thr Ile Gln Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe 
    450                 455                 460                 


Gly Trp Gly Ser His Lys Thr Phe Cys His Trp Glu His Asp Asn His 
465                 470                 475                 480 


Val Gln Leu Lys Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln 
                485                 490                 495     


Asp His Thr Gly Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn 
            500                 505                 510         


Gln Lys Gly Lys Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln 
        515                 520                 525             


Asn Ser Ala His Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His 
    530                 535                 540                 


Val Gly Thr Leu Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr 
545                 550                 555                 560 


Asp Gln Leu Val Trp Met Ala Ile Gly His Gln Gly Asp His Trp Lys 
                565                 570                 575     


Glu Gly Arg Val Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile 
            580                 585                 590         


Phe Glu Gly Glu Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp 
        595                 600                 605             


Asp Ile Ser Ile Asn Asn His Ile Ser Gln Glu Asp Cys Ala Lys Pro 
    610                 615                 620                 


Ala Asp Leu Asp Lys Lys Asn Pro Glu Ile Lys Ile Asp Glu Thr Gly 
625                 630                 635                 640 


Ser Thr Pro Gly Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser 
                645                 650                 655     


Arg Lys Pro Gly Asn Val Leu Lys Thr Leu Asp Pro Ile Leu Ile Thr 
            660                 665                 670         


Ile Ile Ala Met Ser Ala Leu Gly Val Leu Leu Gly Ala Val Cys Gly 
        675                 680                 685             


Val Val Leu Tyr Cys Ala Cys Trp His Asn Gly Met Ser Glu Arg Asn 
    690                 695                 700                 


Leu Ser Ala Leu Glu Asn Tyr Asn Phe Glu Leu Val Asp Gly Val Lys 
705                 710                 715                 720 


Leu Lys Lys Asp Lys Leu Asn Thr Gln Ser Thr Tyr Ser Glu Ala 
                725                 730                 735 


<210>  9538
<211>  105
<212>  PRT
<213>  Homo Sapiens

<400>  9538

Asn His Ile Ser Gln Glu Asp Cys Ala Arg Ser Thr Pro Gly Tyr Glu 
1               5                   10                  15      


Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly Asn Val 
            20                  25                  30          


Leu Lys Thr Leu Asp Pro Ile Leu Ile Thr Ile Ile Ala Met Ser Ala 
        35                  40                  45              


Leu Gly Val Leu Leu Gly Ala Val Cys Gly Val Val Leu Tyr Cys Ala 
    50                  55                  60                  


Cys Trp His Asn Gly Met Ser Glu Arg Asn Leu Ser Ala Leu Glu Asn 
65                  70                  75                  80  


Tyr Asn Phe Glu Leu Val Asp Gly Val Lys Leu Lys Lys Asp Lys Leu 
                85                  90                  95      


Asn Thr Gln Ser Thr Tyr Ser Glu Ala 
            100                 105 


<210>  9539
<211>  60
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9539

Xaa Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val 
1               5                   10                  15      


Arg Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe 
            20                  25                  30          


Met Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys 
        35                  40                  45              


Met Ile Met Asp Asp Ser Lys Arg Lys Ala Leu Ile 
    50                  55                  60  


<210>  9540
<211>  170
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9540

Xaa Pro Gly Gly Met Phe Cys Arg Tyr Asp Arg Leu Glu Ile Trp Asp 
1               5                   10                  15      


Gly Phe Pro Asp Val Gly Pro His Ile Gly Arg Tyr Cys Gly Gln Lys 
            20                  25                  30          


Thr Pro Gly Arg Ile Arg Ser Ser Ser Gly Ile Leu Ser Met Val Phe 
        35                  40                  45              


Tyr Thr Asp Ser Ala Ile Ala Lys Glu Gly Phe Ser Ala Asn Tyr Ser 
    50                  55                  60                  


Val Leu Gln Ser Ser Val Ser Glu Asp Phe Lys Cys Met Glu Ala Leu 
65                  70                  75                  80  


Gly Met Glu Ser Gly Glu Ile His Ser Asp Gln Ile Thr Ala Ser Ser 
                85                  90                  95      


Gln Tyr Ser Thr Asn Trp Ser Ala Glu Arg Ser Arg Leu Asn Tyr Pro 
            100                 105                 110         


Glu Asn Gly Trp Thr Pro Gly Glu Asp Ser Tyr Arg Glu Trp Ile Gln 
        115                 120                 125             


Asp Ala Lys Tyr Arg Leu Arg Val Ser Val Val Arg Ser Lys Ser Ser 
    130                 135                 140                 


Ser Ser Ser Thr Ser Leu Glu Pro Arg Pro Leu Ser Ser Leu Lys Leu 
145                 150                 155                 160 


Ser Phe Phe Ser Tyr Lys Ile Lys Ile Thr 
                165                 170 


<210>  9541
<211>  77
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9541

Xaa Pro Thr Ala Gly Pro Thr Thr Pro Asn Gly Asn Leu Val Asp Glu 
1               5                   10                  15      


Cys Asp Asp Asp Gln Ala Asn Cys His Ser Gly Thr Gly Asp Asp Phe 
            20                  25                  30          


Gln Leu Thr Gly Gly Thr Thr Val Leu Ala Thr Glu Lys Pro Thr Val 
        35                  40                  45              


Ile Asp Ser Thr Ile Gln Ser Ala Arg Leu Glu Val Ser Thr Leu Asn 
    50                  55                  60                  


Leu Ser Leu His Asn Pro Pro Gln Gln Lys Ala Leu Ile 
65                  70                  75          


<210>  9542
<211>  100
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9542

Xaa Thr His Gly Gly Leu Gly Leu Arg Met Glu Leu Leu Gly Cys Glu 
1               5                   10                  15      


Val Glu Ala Pro Thr Ala Gly Pro Thr Thr Pro Asn Gly Asn Leu Val 
            20                  25                  30          


Asp Glu Cys Asp Asp Asp Gln Ala Asn Cys His Ser Gly Thr Gly Asp 
        35                  40                  45              


Asp Phe Gln Leu Thr Gly Gly Thr Thr Val Leu Ala Thr Glu Lys Pro 
    50                  55                  60                  


Thr Val Ile Asp Ser Thr Ile Gln Ser Gly Ser Arg Phe Phe Lys His 
65                  70                  75                  80  


His His Lys Gln Gln Ser Met Arg Pro Gln Asn Leu His His Asn Ser 
                85                  90                  95      


Ile Leu Leu Leu 
            100 


<210>  9543
<211>  102
<212>  PRT
<213>  Homo Sapiens

<400>  9543

Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly 
            100         


<210>  9544
<211>  906
<212>  PRT
<213>  Homo Sapiens

<400>  9544

Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
545                 550                 555                 560 


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
                565                 570                 575     


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
            580                 585                 590         


Asp Trp Thr Asp Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val 
        595                 600                 605             


Lys Ser Glu Glu Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr 
    610                 615                 620                 


Glu Cys Gly Glu Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu 
625                 630                 635                 640 


Pro Ser Gly Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly 
                645                 650                 655     


Trp Met Tyr Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser 
            660                 665                 670         


Ser Ser Pro Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg 
        675                 680                 685             


Leu Gln Ser Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser 
    690                 695                 700                 


Pro Pro Val His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr 
705                 710                 715                 720 


Gln Ala Thr Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala 
                725                 730                 735     


Ser Gln Glu Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly 
            740                 745                 750         


Glu Trp Lys His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr 
        755                 760                 765             


Gln Ile Val Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile 
    770                 775                 780                 


Ala Ile Asp Asp Ile Arg Ile Ser Thr Asp Val Pro Leu Glu Asn Cys 
785                 790                 795                 800 


Met Glu Pro Ile Ser Ala Phe Ala Gly Glu Asn Phe Lys Gly Gly Thr 
                805                 810                 815     


Leu Leu Pro Gly Thr Glu Pro Thr Val Asp Thr Val Pro Met Gln Pro 
            820                 825                 830         


Ile Pro Ala Tyr Trp Tyr Tyr Val Met Ala Ala Gly Gly Ala Val Leu 
        835                 840                 845             


Val Leu Val Ser Val Ala Leu Ala Leu Val Leu His Tyr His Arg Phe 
    850                 855                 860                 


Arg Tyr Ala Ala Lys Lys Thr Asp His Ser Ile Thr Tyr Lys Thr Ser 
865                 870                 875                 880 


His Tyr Thr Asn Gly Ala Pro Leu Ala Val Glu Pro Thr Leu Thr Ile 
                885                 890                 895     


Lys Leu Glu Gln Asp Arg Gly Ser His Cys 
            900                 905     


<210>  9545
<211>  926
<212>  PRT
<213>  Homo Sapiens

<400>  9545

Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
545                 550                 555                 560 


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
                565                 570                 575     


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
            580                 585                 590         


Asp Trp Thr Asp Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val 
        595                 600                 605             


Lys Ser Glu Glu Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr 
    610                 615                 620                 


Glu Cys Gly Glu Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu 
625                 630                 635                 640 


Pro Ser Gly Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly 
                645                 650                 655     


Trp Met Tyr Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser 
            660                 665                 670         


Ser Ser Pro Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg 
        675                 680                 685             


Leu Gln Ser Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser 
    690                 695                 700                 


Pro Pro Val His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr 
705                 710                 715                 720 


Gln Ala Thr Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala 
                725                 730                 735     


Ser Gln Glu Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly 
            740                 745                 750         


Glu Trp Lys His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr 
        755                 760                 765             


Gln Ile Val Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile 
    770                 775                 780                 


Ala Ile Asp Asp Ile Arg Ile Ser Thr Asp Val Pro Leu Glu Asn Cys 
785                 790                 795                 800 


Met Glu Pro Ile Ser Ala Phe Ala Val Asp Ile Pro Glu Ile His Glu 
                805                 810                 815     


Arg Glu Gly Tyr Glu Asp Glu Ile Asp Asp Glu Tyr Glu Val Asp Trp 
            820                 825                 830         


Ser Asn Ser Ser Ser Ala Thr Ser Gly Ser Gly Ala Pro Ser Thr Asp 
        835                 840                 845             


Lys Glu Lys Ser Trp Leu Tyr Thr Leu Asp Pro Ile Leu Ile Thr Ile 
    850                 855                 860                 


Ile Ala Met Ser Ser Leu Gly Val Leu Leu Gly Ala Thr Cys Ala Gly 
865                 870                 875                 880 


Leu Leu Leu Tyr Cys Thr Cys Ser Tyr Ser Gly Leu Ser Ser Arg Ser 
                885                 890                 895     


Cys Thr Thr Leu Glu Asn Tyr Asn Phe Glu Leu Tyr Asp Gly Leu Lys 
            900                 905                 910         


His Lys Val Lys Met Asn His Gln Lys Cys Cys Ser Glu Ala 
        915                 920                 925     


<210>  9546
<211>  931
<212>  PRT
<213>  Homo Sapiens

<400>  9546

Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
545                 550                 555                 560 


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
                565                 570                 575     


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
            580                 585                 590         


Asp Trp Thr Asp Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val 
        595                 600                 605             


Lys Ser Glu Glu Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr 
    610                 615                 620                 


Glu Cys Gly Glu Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu 
625                 630                 635                 640 


Pro Ser Gly Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly 
                645                 650                 655     


Trp Met Tyr Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser 
            660                 665                 670         


Ser Ser Pro Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg 
        675                 680                 685             


Leu Gln Ser Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser 
    690                 695                 700                 


Pro Pro Val His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr 
705                 710                 715                 720 


Gln Ala Thr Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala 
                725                 730                 735     


Ser Gln Glu Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly 
            740                 745                 750         


Glu Trp Lys His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr 
        755                 760                 765             


Gln Ile Val Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile 
    770                 775                 780                 


Ala Ile Asp Asp Ile Arg Ile Ser Thr Asp Val Pro Leu Glu Asn Cys 
785                 790                 795                 800 


Met Glu Pro Ile Ser Ala Phe Ala Gly Glu Asn Phe Lys Val Asp Ile 
                805                 810                 815     


Pro Glu Ile His Glu Arg Glu Gly Tyr Glu Asp Glu Ile Asp Asp Glu 
            820                 825                 830         


Tyr Glu Val Asp Trp Ser Asn Ser Ser Ser Ala Thr Ser Gly Ser Gly 
        835                 840                 845             


Ala Pro Ser Thr Asp Lys Glu Lys Ser Trp Leu Tyr Thr Leu Asp Pro 
    850                 855                 860                 


Ile Leu Ile Thr Ile Ile Ala Met Ser Ser Leu Gly Val Leu Leu Gly 
865                 870                 875                 880 


Ala Thr Cys Ala Gly Leu Leu Leu Tyr Cys Thr Cys Ser Tyr Ser Gly 
                885                 890                 895     


Leu Ser Ser Arg Ser Cys Thr Thr Leu Glu Asn Tyr Asn Phe Glu Leu 
            900                 905                 910         


Tyr Asp Gly Leu Lys His Lys Val Lys Met Asn His Gln Lys Cys Cys 
        915                 920                 925             


Ser Glu Ala 
    930     


<210>  9547
<211>  901
<212>  PRT
<213>  Homo Sapiens

<400>  9547

Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
545                 550                 555                 560 


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
                565                 570                 575     


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
            580                 585                 590         


Asp Trp Thr Asp Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val 
        595                 600                 605             


Lys Ser Glu Glu Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr 
    610                 615                 620                 


Glu Cys Gly Glu Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu 
625                 630                 635                 640 


Pro Ser Gly Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly 
                645                 650                 655     


Trp Met Tyr Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser 
            660                 665                 670         


Ser Ser Pro Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg 
        675                 680                 685             


Leu Gln Ser Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser 
    690                 695                 700                 


Pro Pro Val His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr 
705                 710                 715                 720 


Gln Ala Thr Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala 
                725                 730                 735     


Ser Gln Glu Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly 
            740                 745                 750         


Glu Trp Lys His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr 
        755                 760                 765             


Gln Ile Val Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile 
    770                 775                 780                 


Ala Ile Asp Asp Ile Arg Ile Ser Thr Asp Val Pro Leu Glu Asn Cys 
785                 790                 795                 800 


Met Glu Pro Ile Ser Ala Phe Ala Gly Gly Thr Leu Leu Pro Gly Thr 
                805                 810                 815     


Glu Pro Thr Val Asp Thr Val Pro Met Gln Pro Ile Pro Ala Tyr Trp 
            820                 825                 830         


Tyr Tyr Val Met Ala Ala Gly Gly Ala Val Leu Val Leu Val Ser Val 
        835                 840                 845             


Ala Leu Ala Leu Val Leu His Tyr His Arg Phe Arg Tyr Ala Ala Lys 
    850                 855                 860                 


Lys Thr Asp His Ser Ile Thr Tyr Lys Thr Ser His Tyr Thr Asn Gly 
865                 870                 875                 880 


Ala Pro Leu Ala Val Glu Pro Thr Leu Thr Ile Lys Leu Glu Gln Asp 
                885                 890                 895     


Arg Gly Ser His Cys 
            900     


<210>  9548
<211>  555
<212>  PRT
<213>  Homo Sapiens

<400>  9548

Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Val Gly Cys Ser Trp Arg Pro Leu 
545                 550                 555 


<210>  9549
<211>  909
<212>  PRT
<213>  Homo Sapiens

<400>  9549

Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
545                 550                 555                 560 


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
                565                 570                 575     


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
            580                 585                 590         


Asp Trp Thr Asp Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val 
        595                 600                 605             


Lys Ser Glu Glu Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr 
    610                 615                 620                 


Glu Cys Gly Glu Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu 
625                 630                 635                 640 


Pro Ser Gly Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly 
                645                 650                 655     


Trp Met Tyr Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser 
            660                 665                 670         


Ser Ser Pro Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg 
        675                 680                 685             


Leu Gln Ser Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser 
    690                 695                 700                 


Pro Pro Val His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr 
705                 710                 715                 720 


Gln Ala Thr Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala 
                725                 730                 735     


Ser Gln Glu Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly 
            740                 745                 750         


Glu Trp Lys His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr 
        755                 760                 765             


Gln Ile Val Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile 
    770                 775                 780                 


Ala Ile Asp Asp Ile Arg Ile Ser Thr Asp Val Pro Leu Glu Asn Cys 
785                 790                 795                 800 


Met Glu Pro Ile Ser Ala Phe Ala Asp Glu Tyr Glu Val Asp Trp Ser 
                805                 810                 815     


Asn Ser Ser Ser Ala Thr Ser Gly Ser Gly Ala Pro Ser Thr Asp Lys 
            820                 825                 830         


Glu Lys Ser Trp Leu Tyr Thr Leu Asp Pro Ile Leu Ile Thr Ile Ile 
        835                 840                 845             


Ala Met Ser Ser Leu Gly Val Leu Leu Gly Ala Thr Cys Ala Gly Leu 
    850                 855                 860                 


Leu Leu Tyr Cys Thr Cys Ser Tyr Ser Gly Leu Ser Ser Arg Ser Cys 
865                 870                 875                 880 


Thr Thr Leu Glu Asn Tyr Asn Phe Glu Leu Tyr Asp Gly Leu Lys His 
                885                 890                 895     


Lys Val Lys Met Asn His Gln Lys Cys Cys Ser Glu Ala 
            900                 905                 


<210>  9550
<211>  197
<212>  PRT
<213>  Homo Sapiens

<400>  9550

Met Gln Arg Trp Lys Ala Ala Ala Leu Ala Ser Val Leu Cys Ser Ser 
1               5                   10                  15      


Val Leu Ser Ile Trp Met Cys Arg Glu Gly Leu Leu Leu Ser His Arg 
            20                  25                  30          


Leu Gly Pro Ala Leu Val Pro Leu His Arg Leu Pro Arg Thr Leu Asp 
        35                  40                  45              


Ala Arg Ile Ala Arg Leu Ala Gln Tyr Arg Ala Leu Leu Gln Gly Ala 
    50                  55                  60                  


Pro Asp Ala Met Glu Leu Arg Glu Leu Thr Pro Trp Ala Gly Arg Pro 
65                  70                  75                  80  


Pro Gly Pro Arg Arg Arg Ala Gly Pro Arg Arg Arg Arg Ala Arg Ala 
                85                  90                  95      


Arg Leu Gly Ala Arg Pro Cys Gly Leu Arg Glu Leu Glu Val Arg Val 
            100                 105                 110         


Ser Glu Leu Gly Leu Gly Tyr Ala Ser Asp Glu Thr Val Leu Phe Arg 
        115                 120                 125             


Tyr Cys Ala Gly Ala Cys Glu Ala Ala Ala Arg Val Tyr Asp Leu Gly 
    130                 135                 140                 


Leu Arg Arg Leu Arg Gln Arg Arg Arg Leu Arg Arg Glu Arg Val Arg 
145                 150                 155                 160 


Ala Gln Pro Cys Cys Arg Pro Thr Ala Tyr Glu Asp Glu Val Ser Phe 
                165                 170                 175     


Leu Asp Ala His Ser Arg Tyr His Thr Val His Glu Leu Ser Ala Arg 
            180                 185                 190         


Glu Cys Ala Cys Val 
        195         


<210>  9551
<211>  214
<212>  PRT
<213>  Homo Sapiens

<400>  9551

Asp Leu Gly Asn Gly Ala Asn Leu Ile Lys Gly Ser Ser Asn Lys Pro 
1               5                   10                  15      


Leu Asn Asp Asn Gln Trp His Asn Val Met Ile Ser Arg Asp Thr Ser 
            20                  25                  30          


Asn Leu His Thr Val Lys Ile Asp Thr Lys Ile Thr Thr Gln Ile Thr 
        35                  40                  45              


Ala Gly Ala Arg Asn Leu Asp Leu Lys Ser Asp Leu Tyr Ile Gly Gly 
    50                  55                  60                  


Val Ala Lys Glu Thr Tyr Lys Ser Leu Pro Lys Leu Val His Ala Lys 
65                  70                  75                  80  


Glu Gly Phe Gln Gly Cys Leu Ala Ser Val Asp Leu Asn Gly Arg Leu 
                85                  90                  95      


Pro Asp Leu Ile Ser Asp Ala Leu Phe Cys Asn Gly Gln Ile Glu Arg 
            100                 105                 110         


Gly Cys Glu Val Ala Leu Met Lys Ala Asp Leu Gln Gly Pro Ser Thr 
        115                 120                 125             


Thr Cys Gln Glu Asp Ser Cys Ser Asn Gln Gly Val Cys Leu Gln Gln 
    130                 135                 140                 


Trp Asp Gly Phe Ser Cys Asp Cys Ser Met Thr Ser Phe Ser Gly Pro 
145                 150                 155                 160 


Leu Cys Asn Asp Pro Gly Thr Thr Tyr Ile Phe Ser Lys Gly Gly Gly 
                165                 170                 175     


Gln Ile Thr Tyr Lys Trp Pro Pro Asn Asp Arg Pro Ser Thr Arg Ala 
            180                 185                 190         


Asp Arg Leu Ala Ile Gly Phe Ser Thr Val Gln Lys Glu Ala Val Leu 
        195                 200                 205             


Val Arg Val Asp Ser Ser 
    210                 


<210>  9552
<211>  851
<212>  PRT
<213>  Homo Sapiens

<400>  9552

Gly Lys Glu Glu Tyr Ile Ala Thr Phe Lys Gly Ser Glu Tyr Phe Cys 
1               5                   10                  15      


Tyr Asp Leu Ser Gln Asn Pro Ile Gln Ser Ser Ser Asp Glu Ile Thr 
            20                  25                  30          


Leu Ser Phe Lys Thr Leu Gln Arg Asn Gly Leu Met Leu His Thr Gly 
        35                  40                  45              


Lys Ser Ala Asp Tyr Val Asn Leu Ala Leu Lys Asn Gly Ala Val Ser 
    50                  55                  60                  


Leu Val Ile Asn Leu Gly Ser Gly Ala Phe Glu Ala Leu Val Glu Pro 
65                  70                  75                  80  


Val Asn Gly Lys Phe Asn Asp Asn Ala Trp His Asp Val Lys Val Thr 
                85                  90                  95      


Arg Asn Leu Arg Gln His Ser Gly Ile Gly His Ala Met Val Asn Lys 
            100                 105                 110         


Leu His Cys Ser Val Thr Ile Ser Val Asp Gly Ile Leu Thr Thr Thr 
        115                 120                 125             


Gly Tyr Thr Gln Glu Asp Tyr Thr Met Leu Gly Ser Asp Asp Phe Phe 
    130                 135                 140                 


Tyr Val Gly Gly Ser Pro Ser Thr Ala Asp Leu Pro Gly Ser Pro Val 
145                 150                 155                 160 


Ser Asn Asn Phe Met Gly Cys Leu Lys Glu Val Val Tyr Lys Asn Asn 
                165                 170                 175     


Asp Val Arg Leu Glu Leu Ser Arg Leu Ala Lys Gln Gly Asp Pro Lys 
            180                 185                 190         


Met Lys Ile His Gly Val Val Ala Phe Lys Cys Glu Asn Val Ala Thr 
        195                 200                 205             


Leu Asp Pro Ile Thr Phe Glu Thr Pro Glu Ser Phe Ile Ser Leu Pro 
    210                 215                 220                 


Lys Trp Asn Ala Lys Lys Thr Gly Ser Ile Ser Phe Asp Phe Arg Thr 
225                 230                 235                 240 


Thr Glu Pro Asn Gly Leu Ile Leu Phe Ser His Gly Lys Pro Arg His 
                245                 250                 255     


Gln Lys Asp Ala Lys His Pro Gln Met Ile Lys Val Asp Phe Phe Ala 
            260                 265                 270         


Ile Glu Met Leu Asp Gly His Leu Tyr Leu Leu Leu Asp Met Gly Ser 
        275                 280                 285             


Gly Thr Ile Lys Ile Lys Ala Leu Leu Lys Lys Val Asn Asp Gly Glu 
    290                 295                 300                 


Trp Tyr His Val Asp Phe Gln Arg Asp Gly Arg Ser Gly Thr Ile Ser 
305                 310                 315                 320 


Val Asn Thr Leu Arg Thr Pro Tyr Thr Ala Pro Gly Glu Ser Glu Ile 
                325                 330                 335     


Leu Asp Leu Asp Asp Glu Leu Tyr Leu Gly Gly Leu Pro Glu Asn Lys 
            340                 345                 350         


Ala Gly Leu Val Phe Pro Thr Glu Val Trp Thr Ala Leu Leu Asn Tyr 
        355                 360                 365             


Gly Tyr Val Gly Cys Ile Arg Asp Leu Phe Ile Asp Gly Gln Ser Lys 
    370                 375                 380                 


Asp Ile Arg Gln Met Ala Glu Val Gln Ser Thr Ala Gly Val Lys Pro 
385                 390                 395                 400 


Ser Cys Ser Lys Glu Thr Ala Lys Pro Cys Leu Ser Asn Pro Cys Lys 
                405                 410                 415     


Asn Asn Gly Met Cys Arg Asp Gly Trp Asn Arg Tyr Val Cys Asp Cys 
            420                 425                 430         


Ser Gly Thr Gly Tyr Leu Gly Arg Ser Cys Glu Arg Glu Ala Thr Val 
        435                 440                 445             


Leu Ser Tyr Asp Gly Ser Met Phe Met Lys Ile Gln Leu Pro Val Val 
    450                 455                 460                 


Met His Thr Glu Ala Glu Asp Val Ser Leu Arg Phe Arg Ser Gln Arg 
465                 470                 475                 480 


Ala Tyr Gly Ile Leu Met Ala Thr Thr Ser Arg Asp Ser Ala Asp Thr 
                485                 490                 495     


Leu Arg Leu Glu Leu Asp Ala Gly Arg Val Lys Leu Thr Val Asn Leu 
            500                 505                 510         


Asp Cys Ile Arg Ile Asn Cys Asn Ser Ser Lys Gly Pro Glu Thr Leu 
        515                 520                 525             


Phe Ala Gly Tyr Asn Leu Asn Asp Asn Glu Trp His Thr Val Arg Val 
    530                 535                 540                 


Val Arg Arg Gly Lys Ser Leu Lys Leu Thr Val Asp Asp Gln Gln Ala 
545                 550                 555                 560 


Met Thr Gly Gln Met Ala Gly Asp His Thr Arg Leu Glu Phe His Asn 
                565                 570                 575     


Ile Glu Thr Gly Ile Ile Thr Glu Arg Arg Tyr Leu Ser Ser Val Pro 
            580                 585                 590         


Ser Asn Phe Ile Gly His Leu Gln Ser Leu Thr Phe Asn Gly Met Ala 
        595                 600                 605             


Tyr Ile Asp Leu Cys Lys Asn Gly Asp Ile Asp Tyr Cys Glu Leu Asn 
    610                 615                 620                 


Ala Arg Phe Gly Phe Arg Asn Ile Ile Ala Asp Pro Val Thr Phe Lys 
625                 630                 635                 640 


Thr Lys Ser Ser Tyr Val Ala Leu Ala Thr Leu Gln Ala Tyr Thr Ser 
                645                 650                 655     


Met His Leu Phe Phe Gln Phe Lys Thr Thr Ser Leu Asp Gly Leu Ile 
            660                 665                 670         


Leu Tyr Asn Ser Gly Asp Gly Asn Asp Phe Ile Val Val Glu Leu Val 
        675                 680                 685             


Lys Gly Tyr Leu His Tyr Val Phe Asp Leu Gly Asn Gly Ala Asn Leu 
    690                 695                 700                 


Ile Lys Gly Ser Ser Asn Lys Pro Leu Asn Asp Asn Gln Trp His Asn 
705                 710                 715                 720 


Val Met Ile Ser Arg Asp Thr Ser Asn Leu His Thr Val Lys Ile Asp 
                725                 730                 735     


Thr Lys Ile Thr Thr Gln Ile Thr Ala Gly Ala Arg Asn Leu Asp Leu 
            740                 745                 750         


Lys Ser Asp Leu Tyr Ile Gly Gly Val Ala Lys Glu Thr Tyr Lys Ser 
        755                 760                 765             


Leu Pro Lys Leu Val His Ala Lys Glu Gly Phe Gln Gly Cys Leu Ala 
    770                 775                 780                 


Ser Val Asp Leu Asn Gly Arg Leu Pro Asp Leu Ile Ser Asp Ala Leu 
785                 790                 795                 800 


Phe Cys Asn Gly Gln Ile Glu Arg Gly Cys Glu Gly Pro Ser Thr Thr 
                805                 810                 815     


Cys Gln Glu Asp Ser Cys Ser Asn Gln Gly Val Cys Leu Gln Gln Trp 
            820                 825                 830         


Asp Gly Phe Ser Cys Asp Cys Ser Met Thr Ser Phe Ser Gly Pro Leu 
        835                 840                 845             


Cys Asn Asp 
    850     


<210>  9553
<211>  836
<212>  PRT
<213>  Homo Sapiens

<400>  9553

Gly Lys Glu Glu Tyr Ile Ala Thr Phe Lys Gly Ser Glu Tyr Phe Cys 
1               5                   10                  15      


Tyr Asp Leu Ser Gln Asn Pro Ile Gln Ser Ser Ser Asp Glu Ile Thr 
            20                  25                  30          


Leu Ser Phe Lys Thr Leu Gln Arg Asn Gly Leu Met Leu His Thr Gly 
        35                  40                  45              


Lys Ser Ala Asp Tyr Val Asn Leu Ala Leu Lys Asn Gly Ala Val Ser 
    50                  55                  60                  


Leu Val Ile Asn Leu Gly Ser Gly Ala Phe Glu Ala Leu Val Glu Pro 
65                  70                  75                  80  


Val Asn Gly Lys Phe Asn Asp Asn Ala Trp His Asp Val Lys Val Thr 
                85                  90                  95      


Arg Asn Leu Arg Gln Val Thr Ile Ser Val Asp Gly Ile Leu Thr Thr 
            100                 105                 110         


Thr Gly Tyr Thr Gln Glu Asp Tyr Thr Met Leu Gly Ser Asp Asp Phe 
        115                 120                 125             


Phe Tyr Val Gly Gly Ser Pro Ser Thr Ala Asp Leu Pro Gly Ser Pro 
    130                 135                 140                 


Val Ser Asn Asn Phe Met Gly Cys Leu Lys Glu Val Val Tyr Lys Asn 
145                 150                 155                 160 


Asn Asp Val Arg Leu Glu Leu Ser Arg Leu Ala Lys Gln Gly Asp Pro 
                165                 170                 175     


Lys Met Lys Ile His Gly Val Val Ala Phe Lys Cys Glu Asn Val Ala 
            180                 185                 190         


Thr Leu Asp Pro Ile Thr Phe Glu Thr Pro Glu Ser Phe Ile Ser Leu 
        195                 200                 205             


Pro Lys Trp Asn Ala Lys Lys Thr Gly Ser Ile Ser Phe Asp Phe Arg 
    210                 215                 220                 


Thr Thr Glu Pro Asn Gly Leu Ile Leu Phe Ser His Gly Lys Pro Arg 
225                 230                 235                 240 


His Gln Lys Asp Ala Lys His Pro Gln Met Ile Lys Val Asp Phe Phe 
                245                 250                 255     


Ala Ile Glu Met Leu Asp Gly His Leu Tyr Leu Leu Leu Asp Met Gly 
            260                 265                 270         


Ser Gly Thr Ile Lys Ile Lys Ala Leu Leu Lys Lys Val Asn Asp Gly 
        275                 280                 285             


Glu Trp Tyr His Val Asp Phe Gln Arg Asp Gly Arg Ser Gly Thr Ile 
    290                 295                 300                 


Ser Val Asn Thr Leu Arg Thr Pro Tyr Thr Ala Pro Gly Glu Ser Glu 
305                 310                 315                 320 


Ile Leu Asp Leu Asp Asp Glu Leu Tyr Leu Gly Gly Leu Pro Glu Asn 
                325                 330                 335     


Lys Ala Gly Leu Val Phe Pro Thr Glu Val Trp Thr Ala Leu Leu Asn 
            340                 345                 350         


Tyr Gly Tyr Val Gly Cys Ile Arg Asp Leu Phe Ile Asp Gly Gln Ser 
        355                 360                 365             


Lys Asp Ile Arg Gln Met Ala Glu Val Gln Ser Thr Ala Gly Val Lys 
    370                 375                 380                 


Pro Ser Cys Ser Lys Glu Thr Ala Lys Pro Cys Leu Ser Asn Pro Cys 
385                 390                 395                 400 


Lys Asn Asn Gly Met Cys Arg Asp Gly Trp Asn Arg Tyr Val Cys Asp 
                405                 410                 415     


Cys Ser Gly Thr Gly Tyr Leu Gly Arg Ser Cys Glu Arg Glu Ala Thr 
            420                 425                 430         


Val Leu Ser Tyr Asp Gly Ser Met Phe Met Lys Ile Gln Leu Pro Val 
        435                 440                 445             


Val Met His Thr Glu Ala Glu Asp Val Ser Leu Arg Phe Arg Ser Gln 
    450                 455                 460                 


Arg Ala Tyr Gly Ile Leu Met Ala Thr Thr Ser Arg Asp Ser Ala Asp 
465                 470                 475                 480 


Thr Leu Arg Leu Glu Leu Asp Ala Gly Arg Val Lys Leu Thr Val Asn 
                485                 490                 495     


Leu Asp Cys Ile Arg Ile Asn Cys Asn Ser Ser Lys Gly Pro Glu Thr 
            500                 505                 510         


Leu Phe Ala Gly Tyr Asn Leu Asn Asp Asn Glu Trp His Thr Val Arg 
        515                 520                 525             


Val Val Arg Arg Gly Lys Ser Leu Lys Leu Thr Val Asp Asp Gln Gln 
    530                 535                 540                 


Ala Met Thr Gly Gln Met Ala Gly Asp His Thr Arg Leu Glu Phe His 
545                 550                 555                 560 


Asn Ile Glu Thr Gly Ile Ile Thr Glu Arg Arg Tyr Leu Ser Ser Val 
                565                 570                 575     


Pro Ser Asn Phe Ile Gly His Leu Gln Ser Leu Thr Phe Asn Gly Met 
            580                 585                 590         


Ala Tyr Ile Asp Leu Cys Lys Asn Gly Asp Ile Asp Tyr Cys Glu Leu 
        595                 600                 605             


Asn Ala Arg Phe Gly Phe Arg Asn Ile Ile Ala Asp Pro Val Thr Phe 
    610                 615                 620                 


Lys Thr Lys Ser Ser Tyr Val Ala Leu Ala Thr Leu Gln Ala Tyr Thr 
625                 630                 635                 640 


Ser Met His Leu Phe Phe Gln Phe Lys Thr Thr Ser Leu Asp Gly Leu 
                645                 650                 655     


Ile Leu Tyr Asn Ser Gly Asp Gly Asn Asp Phe Ile Val Val Glu Leu 
            660                 665                 670         


Val Lys Gly Tyr Leu His Tyr Val Phe Asp Leu Gly Asn Gly Ala Asn 
        675                 680                 685             


Leu Ile Lys Gly Ser Ser Asn Lys Pro Leu Asn Asp Asn Gln Trp His 
    690                 695                 700                 


Asn Val Met Ile Ser Arg Asp Thr Ser Asn Leu His Thr Val Lys Ile 
705                 710                 715                 720 


Asp Thr Lys Ile Thr Thr Gln Ile Thr Ala Gly Ala Arg Asn Leu Asp 
                725                 730                 735     


Leu Lys Ser Asp Leu Tyr Ile Gly Gly Val Ala Lys Glu Thr Tyr Lys 
            740                 745                 750         


Ser Leu Pro Lys Leu Val His Ala Lys Glu Gly Phe Gln Gly Cys Leu 
        755                 760                 765             


Ala Ser Val Asp Leu Asn Gly Arg Leu Pro Asp Leu Ile Ser Asp Ala 
    770                 775                 780                 


Leu Phe Cys Asn Gly Gln Ile Glu Arg Gly Cys Glu Gly Pro Ser Thr 
785                 790                 795                 800 


Thr Cys Gln Glu Asp Ser Cys Ser Asn Gln Gly Val Cys Leu Gln Gln 
                805                 810                 815     


Trp Asp Gly Phe Ser Cys Asp Cys Ser Met Thr Ser Phe Ser Gly Pro 
            820                 825                 830         


Leu Cys Asn Asp 
        835     


<210>  9554
<211>  198
<212>  PRT
<213>  Homo Sapiens

<400>  9554

Met Ala Ala Glu Asn Asp Ala Asn Ile Ala Ile Val Gly Asn Val Arg 
1               5                   10                  15      


Leu Val Gly Glu Val Pro Ser Ser Met Thr Thr Glu Ser Thr Ala Thr 
            20                  25                  30          


Ala Met Gln Ser Glu Met Ser Thr Ser Ile Met Glu Thr Thr Thr Thr 
        35                  40                  45              


Leu Ala Thr Ser Thr Ala Arg Arg Gly Lys Pro Pro Thr Lys Glu Pro 
    50                  55                  60                  


Ile Ser Gln Thr Thr Asp Asp Ile Leu Val Ala Ser Ala Glu Cys Pro 
65                  70                  75                  80  


Ser Asp Asp Glu Asp Ile Asp Pro Cys Glu Pro Ser Ser Gly Gly Leu 
                85                  90                  95      


Ala Asn Pro Thr Arg Ala Gly Gly Arg Glu Pro Tyr Pro Gly Ser Ala 
            100                 105                 110         


Glu Val Ile Arg Glu Ser Ser Ser Thr Thr Gly Met Val Val Gly Ile 
        115                 120                 125             


Val Ala Ala Ala Ala Leu Cys Ile Leu Ile Leu Leu Tyr Ala Met Tyr 
    130                 135                 140                 


Lys Tyr Arg Asn Arg Asp Glu Gly Ser Tyr His Val Asp Glu Ser Arg 
145                 150                 155                 160 


Asn Tyr Ile Ser Asn Ser Ala Gln Ser Asn Gly Ala Val Val Lys Glu 
                165                 170                 175     


Lys Gln Pro Ser Ser Ala Lys Ser Ser Asn Lys Asn Lys Lys Asn Lys 
            180                 185                 190         


Asp Lys Glu Tyr Tyr Val 
        195             


<210>  9555
<211>  139
<212>  PRT
<213>  Homo Sapiens

<400>  9555

Met Asp Met Arg Trp His Cys Glu Asn Leu Gln Thr Thr Asp Asp Ile 
1               5                   10                  15      


Leu Val Ala Ser Ala Glu Cys Pro Ser Asp Asp Glu Asp Ile Asp Pro 
            20                  25                  30          


Cys Glu Pro Ser Ser Ala Asn Pro Thr Arg Ala Gly Gly Arg Glu Pro 
        35                  40                  45              


Tyr Pro Gly Ser Ala Glu Val Ile Arg Glu Ser Ser Ser Thr Thr Gly 
    50                  55                  60                  


Met Val Val Gly Ile Val Ala Ala Ala Ala Leu Cys Ile Leu Ile Leu 
65                  70                  75                  80  


Leu Tyr Ala Met Tyr Lys Tyr Arg Asn Arg Asp Glu Gly Ser Tyr His 
                85                  90                  95      


Val Asp Glu Ser Arg Asn Tyr Ile Ser Asn Ser Ala Gln Ser Asn Gly 
            100                 105                 110         


Ala Val Val Lys Glu Lys Gln Pro Ser Ser Ala Lys Ser Ser Asn Lys 
        115                 120                 125             


Asn Lys Lys Asn Lys Asp Lys Glu Tyr Tyr Val 
    130                 135                 


<210>  9556
<211>  142
<212>  PRT
<213>  Homo Sapiens

<400>  9556

Met Asp Met Arg Trp His Cys Glu Asn Leu Gln Thr Thr Asp Asp Ile 
1               5                   10                  15      


Leu Val Ala Ser Ala Glu Cys Pro Ser Asp Asp Glu Asp Ile Asp Pro 
            20                  25                  30          


Cys Glu Pro Ser Ser Gly Gly Leu Ala Asn Pro Thr Arg Ala Gly Gly 
        35                  40                  45              


Arg Glu Pro Tyr Pro Gly Ser Ala Glu Val Ile Arg Glu Ser Ser Ser 
    50                  55                  60                  


Thr Thr Gly Met Val Val Gly Ile Val Ala Ala Ala Ala Leu Cys Ile 
65                  70                  75                  80  


Leu Ile Leu Leu Tyr Ala Met Tyr Lys Tyr Arg Asn Arg Asp Glu Gly 
                85                  90                  95      


Ser Tyr His Val Asp Glu Ser Arg Asn Tyr Ile Ser Asn Ser Ala Gln 
            100                 105                 110         


Ser Asn Gly Ala Val Val Lys Glu Lys Gln Pro Ser Ser Ala Lys Ser 
        115                 120                 125             


Ser Asn Lys Asn Lys Lys Asn Lys Asp Lys Glu Tyr Tyr Val 
    130                 135                 140         


<210>  9557
<211>  62
<212>  PRT
<213>  Homo Sapiens

<400>  9557

Met Asp Met Arg Trp His Cys Glu Asn Leu Gln Thr Thr Asp Asp Ile 
1               5                   10                  15      


Leu Val Ala Ser Ala Glu Cys Pro Ser Asp Asp Glu Asp Ile Asp Pro 
            20                  25                  30          


Cys Glu Pro Ser Ser Gly Thr Lys Gln Thr Met Trp Lys Thr Ser Arg 
        35                  40                  45              


Asp His Arg Ile Leu Pro Asn Ala Arg Arg Glu Arg Lys Asp 
    50                  55                  60          


<210>  9558
<211>  143
<212>  PRT
<213>  Homo Sapiens

<400>  9558

Met Asp Met Arg Trp His Cys Glu Asn Leu Gln Val Thr Thr Asp Asp 
1               5                   10                  15      


Ile Leu Val Ala Ser Ala Glu Cys Pro Ser Asp Asp Glu Asp Ile Asp 
            20                  25                  30          


Pro Cys Glu Pro Ser Ser Gly Gly Leu Ala Asn Pro Thr Arg Ala Gly 
        35                  40                  45              


Gly Arg Glu Pro Tyr Pro Gly Ser Ala Glu Val Ile Arg Glu Ser Ser 
    50                  55                  60                  


Ser Thr Thr Gly Met Val Val Gly Ile Val Ala Ala Ala Ala Leu Cys 
65                  70                  75                  80  


Ile Leu Ile Leu Leu Tyr Ala Met Tyr Lys Tyr Arg Asn Arg Asp Glu 
                85                  90                  95      


Gly Ser Tyr His Val Asp Glu Ser Arg Asn Tyr Ile Ser Asn Ser Ala 
            100                 105                 110         


Gln Ser Asn Gly Ala Val Val Lys Glu Lys Gln Pro Ser Ser Ala Lys 
        115                 120                 125             


Ser Ser Asn Lys Asn Lys Lys Asn Lys Asp Lys Glu Tyr Tyr Val 
    130                 135                 140             


<210>  9559
<211>  1477
<212>  PRT
<213>  Homo Sapiens

<400>  9559

Met Gly Thr Ala Leu Leu Gln Arg Gly Gly Cys Phe Leu Leu Cys Leu 
1               5                   10                  15      


Ser Leu Leu Leu Leu Gly Cys Trp Ala Glu Leu Gly Ser Gly Leu Glu 
            20                  25                  30          


Phe Pro Gly Ala Glu Gly Gln Trp Thr Arg Phe Pro Lys Trp Asn Ala 
        35                  40                  45              


Cys Cys Glu Ser Glu Met Ser Phe Gln Leu Lys Thr Arg Ser Ala Arg 
    50                  55                  60                  


Gly Leu Val Leu Tyr Phe Asp Asp Glu Gly Phe Cys Asp Phe Leu Glu 
65                  70                  75                  80  


Leu Ile Leu Thr Arg Gly Gly Arg Leu Gln Leu Ser Phe Ser Ile Phe 
                85                  90                  95      


Cys Ala Glu Pro Ala Thr Leu Leu Ala Asp Thr Pro Val Asn Asp Gly 
            100                 105                 110         


Ala Trp His Ser Val Arg Ile Arg Arg Gln Phe Arg Asn Thr Thr Leu 
        115                 120                 125             


Phe Ile Asp Gln Val Glu Ala Lys Trp Val Glu Val Lys Ser Lys Arg 
    130                 135                 140                 


Arg Asp Met Thr Val Phe Ser Gly Leu Phe Val Gly Gly Leu Pro Pro 
145                 150                 155                 160 


Glu Leu Arg Ala Ala Ala Leu Lys Leu Thr Leu Ala Ser Val Arg Glu 
                165                 170                 175     


Arg Glu Pro Phe Lys Gly Trp Ile Arg Asp Val Arg Val Asn Ser Ser 
            180                 185                 190         


Gln Val Leu Pro Val Asp Ser Gly Glu Val Lys Leu Asp Asp Glu Pro 
        195                 200                 205             


Pro Asn Ser Gly Gly Gly Ser Pro Cys Glu Ala Gly Glu Glu Gly Glu 
    210                 215                 220                 


Gly Gly Val Cys Leu Asn Gly Gly Val Cys Ser Val Val Asp Asp Gln 
225                 230                 235                 240 


Ala Val Cys Asp Cys Ser Arg Thr Gly Phe Arg Gly Lys Asp Cys Ser 
                245                 250                 255     


Gln Glu Asp Asn Asn Val Glu Gly Leu Ala His Leu Met Met Gly Asp 
            260                 265                 270         


Gln Gly Lys Ser Lys Gly Lys Glu Glu Tyr Ile Ala Thr Phe Lys Gly 
        275                 280                 285             


Ser Glu Tyr Phe Cys Tyr Asp Leu Ser Gln Asn Pro Ile Gln Ser Ser 
    290                 295                 300                 


Ser Asp Glu Ile Thr Leu Ser Phe Lys Thr Leu Gln Arg Asn Gly Leu 
305                 310                 315                 320 


Met Leu His Thr Gly Lys Ser Ala Asp Tyr Val Asn Leu Ala Leu Lys 
                325                 330                 335     


Asn Gly Ala Val Ser Leu Val Ile Asn Leu Gly Ser Gly Ala Phe Glu 
            340                 345                 350         


Ala Leu Val Glu Pro Val Asn Gly Lys Phe Asn Asp Asn Ala Trp His 
        355                 360                 365             


Asp Val Lys Val Thr Arg Asn Leu Arg Gln His Ser Gly Ile Gly His 
    370                 375                 380                 


Ala Met Val Thr Ile Ser Val Asp Gly Ile Leu Thr Thr Thr Gly Tyr 
385                 390                 395                 400 


Thr Gln Glu Asp Tyr Thr Met Leu Gly Ser Asp Asp Phe Phe Tyr Val 
                405                 410                 415     


Gly Gly Ser Pro Ser Thr Ala Asp Leu Pro Gly Ser Pro Val Ser Asn 
            420                 425                 430         


Asn Phe Met Gly Cys Leu Lys Glu Val Val Tyr Lys Asn Asn Asp Val 
        435                 440                 445             


Arg Leu Glu Leu Ser Arg Leu Ala Lys Gln Gly Asp Pro Lys Met Lys 
    450                 455                 460                 


Ile His Gly Val Val Ala Phe Lys Cys Glu Asn Val Ala Thr Leu Asp 
465                 470                 475                 480 


Pro Ile Thr Phe Glu Thr Pro Glu Ser Phe Ile Ser Leu Pro Lys Trp 
                485                 490                 495     


Asn Ala Lys Lys Thr Gly Ser Ile Ser Phe Asp Phe Arg Thr Thr Glu 
            500                 505                 510         


Pro Asn Gly Leu Ile Leu Phe Ser His Gly Lys Pro Arg His Gln Lys 
        515                 520                 525             


Asp Ala Lys His Pro Gln Met Ile Lys Val Asp Phe Phe Ala Ile Glu 
    530                 535                 540                 


Met Leu Asp Gly His Leu Tyr Leu Leu Leu Asp Met Gly Ser Gly Thr 
545                 550                 555                 560 


Ile Lys Ile Lys Ala Leu Leu Lys Lys Val Asn Asp Gly Glu Trp Tyr 
                565                 570                 575     


His Val Asp Phe Gln Arg Asp Gly Arg Ser Gly Thr Ile Ser Val Asn 
            580                 585                 590         


Thr Leu Arg Thr Pro Tyr Thr Ala Pro Gly Glu Ser Glu Ile Leu Asp 
        595                 600                 605             


Leu Asp Asp Glu Leu Tyr Leu Gly Gly Leu Pro Glu Asn Lys Ala Gly 
    610                 615                 620                 


Leu Val Phe Pro Thr Glu Val Trp Thr Ala Leu Leu Asn Tyr Gly Tyr 
625                 630                 635                 640 


Val Gly Cys Ile Arg Asp Leu Phe Ile Asp Gly Gln Ser Lys Asp Ile 
                645                 650                 655     


Arg Gln Met Ala Glu Val Gln Ser Thr Ala Gly Val Lys Pro Ser Cys 
            660                 665                 670         


Ser Lys Glu Thr Ala Lys Pro Cys Leu Ser Asn Pro Cys Lys Asn Asn 
        675                 680                 685             


Gly Met Cys Arg Asp Gly Trp Asn Arg Tyr Val Cys Asp Cys Ser Gly 
    690                 695                 700                 


Thr Gly Tyr Leu Gly Arg Ser Cys Glu Arg Glu Ala Thr Val Leu Ser 
705                 710                 715                 720 


Tyr Asp Gly Ser Met Phe Met Lys Ile Gln Leu Pro Val Val Met His 
                725                 730                 735     


Thr Glu Ala Glu Asp Val Ser Leu Arg Phe Arg Ser Gln Arg Ala Tyr 
            740                 745                 750         


Gly Ile Leu Met Ala Thr Thr Ser Arg Asp Ser Ala Asp Thr Leu Arg 
        755                 760                 765             


Leu Glu Leu Asp Ala Gly Arg Val Lys Leu Thr Val Asn Leu Asp Cys 
    770                 775                 780                 


Ile Arg Ile Asn Cys Asn Ser Ser Lys Gly Pro Glu Thr Leu Phe Ala 
785                 790                 795                 800 


Gly Tyr Asn Leu Asn Asp Asn Glu Trp His Thr Val Arg Val Val Arg 
                805                 810                 815     


Arg Gly Lys Ser Leu Lys Leu Thr Val Asp Asp Gln Gln Ala Met Thr 
            820                 825                 830         


Gly Gln Met Ala Gly Asp His Thr Arg Leu Glu Phe His Asn Ile Glu 
        835                 840                 845             


Thr Gly Ile Ile Thr Glu Arg Arg Tyr Leu Ser Ser Val Pro Ser Asn 
    850                 855                 860                 


Phe Ile Gly His Leu Gln Ser Leu Thr Phe Asn Gly Met Ala Tyr Ile 
865                 870                 875                 880 


Asp Leu Cys Lys Asn Gly Asp Ile Asp Tyr Cys Glu Leu Asn Ala Arg 
                885                 890                 895     


Phe Gly Phe Arg Asn Ile Ile Ala Asp Pro Val Thr Phe Lys Thr Lys 
            900                 905                 910         


Ser Ser Tyr Val Ala Leu Ala Thr Leu Gln Ala Tyr Thr Ser Met His 
        915                 920                 925             


Leu Phe Phe Gln Phe Lys Thr Thr Ser Leu Asp Gly Leu Ile Leu Tyr 
    930                 935                 940                 


Asn Ser Gly Asp Gly Asn Asp Phe Ile Val Val Glu Leu Val Lys Gly 
945                 950                 955                 960 


Tyr Leu His Tyr Val Phe Asp Leu Gly Asn Gly Ala Asn Leu Ile Lys 
                965                 970                 975     


Gly Ser Ser Asn Lys Pro Leu Asn Asp Asn Gln Trp His Asn Val Met 
            980                 985                 990         


Ile Ser Arg Asp Thr Ser Asn Leu  His Thr Val Lys Ile  Asp Thr Lys 
        995                 1000                 1005             


Ile Thr  Thr Gln Ile Thr Ala  Gly Ala Arg Asn Leu  Asp Leu Lys 
    1010                 1015                 1020             


Ser Asp  Leu Tyr Ile Gly Gly  Val Ala Lys Glu Thr  Tyr Lys Ser 
    1025                 1030                 1035             


Leu Pro  Lys Leu Val His Ala  Lys Glu Gly Phe Gln  Gly Cys Leu 
    1040                 1045                 1050             


Ala Ser  Val Asp Leu Asn Gly  Arg Leu Pro Asp Leu  Ile Ser Asp 
    1055                 1060                 1065             


Ala Leu  Phe Cys Asn Gly Gln  Ile Glu Arg Gly Cys  Glu Gly Pro 
    1070                 1075                 1080             


Ser Thr  Thr Cys Gln Glu Asp  Ser Cys Ser Asn Gln  Gly Val Cys 
    1085                 1090                 1095             


Leu Gln  Gln Trp Asp Gly Phe  Ser Cys Asp Cys Ser  Met Thr Ser 
    1100                 1105                 1110             


Phe Ser  Gly Pro Leu Cys Asn  Asp Pro Gly Thr Thr  Tyr Ile Phe 
    1115                 1120                 1125             


Ser Lys  Gly Gly Gly Gln Ile  Thr Tyr Lys Trp Pro  Pro Asn Asp 
    1130                 1135                 1140             


Arg Pro  Ser Thr Arg Ala Asp  Arg Leu Ala Ile Gly  Phe Ser Thr 
    1145                 1150                 1155             


Val Gln  Lys Glu Ala Val Leu  Val Arg Val Asp Ser  Ser Ser Gly 
    1160                 1165                 1170             


Leu Gly  Asp Tyr Leu Glu Leu  His Ile His Gln Gly  Lys Ile Gly 
    1175                 1180                 1185             


Val Lys  Phe Asn Val Gly Thr  Asp Asp Ile Ala Ile  Glu Glu Ser 
    1190                 1195                 1200             


Asn Ala  Ile Ile Asn Asp Gly  Lys Tyr His Val Val  Arg Phe Thr 
    1205                 1210                 1215             


Arg Ser  Gly Gly Asn Ala Thr  Leu Gln Val Asp Ser  Trp Pro Val 
    1220                 1225                 1230             


Ile Glu  Arg Tyr Pro Ala Gly  Arg Gln Leu Thr Ile  Phe Asn Ser 
    1235                 1240                 1245             


Gln Ala  Thr Ile Ile Ile Gly  Gly Lys Glu Gln Gly  Gln Pro Phe 
    1250                 1255                 1260             


Gln Gly  Gln Leu Ser Gly Leu  Tyr Tyr Asn Gly Leu  Lys Val Leu 
    1265                 1270                 1275             


Asn Met  Ala Ala Glu Asn Asp  Ala Asn Ile Ala Ile  Val Gly Asn 
    1280                 1285                 1290             


Val Arg  Leu Val Gly Glu Val  Pro Ser Ser Met Thr  Thr Glu Ser 
    1295                 1300                 1305             


Thr Ala  Thr Ala Met Gln Ser  Glu Met Ser Thr Ser  Ile Met Glu 
    1310                 1315                 1320             


Thr Thr  Thr Thr Leu Ala Thr  Ser Thr Ala Arg Arg  Gly Lys Pro 
    1325                 1330                 1335             


Pro Thr  Lys Glu Pro Ile Ser  Gln Thr Thr Asp Asp  Ile Leu Val 
    1340                 1345                 1350             


Ala Ser  Ala Glu Cys Pro Ser  Asp Asp Glu Asp Ile  Asp Pro Cys 
    1355                 1360                 1365             


Glu Pro  Ser Ser Gly Gly Leu  Ala Asn Pro Thr Arg  Ala Gly Gly 
    1370                 1375                 1380             


Arg Glu  Pro Tyr Pro Gly Ser  Ala Glu Val Ile Arg  Glu Ser Ser 
    1385                 1390                 1395             


Ser Thr  Thr Gly Met Val Val  Gly Ile Val Ala Ala  Ala Ala Leu 
    1400                 1405                 1410             


Cys Ile  Leu Ile Leu Leu Tyr  Ala Met Tyr Lys Tyr  Arg Asn Arg 
    1415                 1420                 1425             


Asp Glu  Gly Ser Tyr His Val  Asp Glu Ser Arg Asn  Tyr Ile Ser 
    1430                 1435                 1440             


Asn Ser  Ala Gln Ser Asn Gly  Ala Val Val Lys Glu  Lys Gln Pro 
    1445                 1450                 1455             


Ser Ser  Ala Lys Ser Ser Asn  Lys Asn Lys Lys Asn  Lys Asp Lys 
    1460                 1465                 1470             


Glu Tyr  Tyr Val 
    1475         


<210>  9560
<211>  278
<212>  PRT
<213>  Homo Sapiens

<400>  9560

Met Gly Thr Ala Leu Leu Gln Arg Gly Gly Cys Phe Leu Leu Cys Leu 
1               5                   10                  15      


Ser Leu Leu Leu Leu Gly Cys Trp Ala Glu Leu Gly Ser Gly Leu Glu 
            20                  25                  30          


Phe Pro Gly Ala Glu Gly Gln Trp Thr Arg Phe Pro Lys Trp Asn Ala 
        35                  40                  45              


Cys Cys Glu Ser Glu Met Ser Phe Gln Leu Lys Thr Arg Ser Ala Arg 
    50                  55                  60                  


Gly Leu Val Leu Tyr Phe Asp Asp Glu Gly Phe Cys Asp Phe Leu Glu 
65                  70                  75                  80  


Leu Ile Leu Thr Arg Gly Gly Arg Leu Gln Leu Ser Phe Ser Ile Phe 
                85                  90                  95      


Cys Ala Glu Pro Ala Thr Leu Leu Ala Asp Thr Pro Val Asn Asp Gly 
            100                 105                 110         


Ala Trp His Ser Val Arg Ile Arg Arg Gln Phe Arg Asn Thr Thr Leu 
        115                 120                 125             


Phe Ile Asp Gln Val Glu Ala Lys Trp Val Glu Val Lys Ser Lys Arg 
    130                 135                 140                 


Arg Asp Met Thr Val Phe Ser Gly Leu Phe Val Gly Gly Leu Pro Pro 
145                 150                 155                 160 


Glu Leu Arg Ala Ala Ala Leu Lys Leu Thr Leu Ala Ser Val Arg Glu 
                165                 170                 175     


Arg Glu Pro Phe Lys Gly Trp Ile Arg Asp Val Arg Val Asn Ser Ser 
            180                 185                 190         


Gln Val Leu Pro Val Asp Ser Gly Glu Val Lys Leu Asp Asp Glu Pro 
        195                 200                 205             


Pro Asn Ser Gly Gly Gly Ser Pro Cys Glu Ala Gly Glu Glu Gly Glu 
    210                 215                 220                 


Gly Gly Val Cys Leu Asn Gly Gly Val Cys Ser Val Val Asp Asp Gln 
225                 230                 235                 240 


Ala Val Cys Asp Cys Ser Arg Thr Gly Phe Arg Gly Lys Asp Cys Ser 
                245                 250                 255     


Gln Glu Asp Asn Asn Val Glu Gly Leu Ala His Leu Met Met Gly Asp 
            260                 265                 270         


Gln Gly Lys Ser Lys Asp 
        275             


<210>  9561
<211>  1547
<212>  PRT
<213>  Homo Sapiens

<400>  9561

Met Gly Thr Ala Leu Leu Gln Arg Gly Gly Cys Phe Leu Leu Cys Leu 
1               5                   10                  15      


Ser Leu Leu Leu Leu Gly Cys Trp Ala Glu Leu Gly Ser Gly Leu Glu 
            20                  25                  30          


Phe Pro Gly Ala Glu Gly Gln Trp Thr Arg Phe Pro Lys Trp Asn Ala 
        35                  40                  45              


Cys Cys Glu Ser Glu Met Ser Phe Gln Leu Lys Thr Arg Ser Ala Arg 
    50                  55                  60                  


Gly Leu Val Leu Tyr Phe Asp Asp Glu Gly Phe Cys Asp Phe Leu Glu 
65                  70                  75                  80  


Leu Ile Leu Thr Arg Gly Gly Arg Leu Gln Leu Ser Phe Ser Ile Phe 
                85                  90                  95      


Cys Ala Glu Pro Ala Thr Leu Leu Ala Asp Thr Pro Val Asn Asp Gly 
            100                 105                 110         


Ala Trp His Ser Val Arg Ile Arg Arg Gln Phe Arg Asn Thr Thr Leu 
        115                 120                 125             


Phe Ile Asp Gln Val Glu Ala Lys Trp Val Glu Val Lys Ser Lys Arg 
    130                 135                 140                 


Arg Asp Met Thr Val Phe Ser Gly Leu Phe Val Gly Gly Leu Pro Pro 
145                 150                 155                 160 


Glu Leu Arg Ala Ala Ala Leu Lys Leu Thr Leu Ala Ser Val Arg Glu 
                165                 170                 175     


Arg Glu Pro Phe Lys Gly Trp Ile Arg Asp Val Arg Val Asn Ser Ser 
            180                 185                 190         


Gln Val Leu Pro Val Asp Ser Gly Glu Val Lys Leu Asp Asp Glu Pro 
        195                 200                 205             


Pro Asn Ser Gly Gly Gly Ser Pro Cys Glu Ala Gly Glu Glu Gly Glu 
    210                 215                 220                 


Gly Gly Val Cys Leu Asn Gly Gly Val Cys Ser Val Val Asp Asp Gln 
225                 230                 235                 240 


Ala Val Cys Asp Cys Ser Arg Thr Gly Phe Arg Gly Lys Asp Cys Ser 
                245                 250                 255     


Gln Glu Ile Lys Phe Gly Leu Gln Cys Val Leu Pro Val Leu Leu His 
            260                 265                 270         


Asp Asn Asp Gln Gly Lys Tyr Cys Cys Ile Asn Thr Ala Lys Pro Leu 
        275                 280                 285             


Thr Glu Lys Asp Asn Asn Val Glu Gly Leu Ala His Leu Met Met Gly 
    290                 295                 300                 


Asp Gln Gly Lys Ser Lys Gly Lys Glu Glu Tyr Ile Ala Thr Phe Lys 
305                 310                 315                 320 


Gly Ser Glu Tyr Phe Cys Tyr Asp Leu Ser Gln Asn Pro Ile Gln Ser 
                325                 330                 335     


Ser Ser Asp Glu Ile Thr Leu Ser Phe Lys Thr Leu Gln Arg Asn Gly 
            340                 345                 350         


Leu Met Leu His Thr Gly Lys Ser Ala Asp Tyr Val Asn Leu Ala Leu 
        355                 360                 365             


Lys Asn Gly Ala Val Ser Leu Val Ile Asn Leu Gly Ser Gly Ala Phe 
    370                 375                 380                 


Glu Ala Leu Val Glu Pro Val Asn Gly Lys Phe Asn Asp Asn Ala Trp 
385                 390                 395                 400 


His Asp Val Lys Val Thr Arg Asn Leu Arg Gln His Ser Gly Ile Gly 
                405                 410                 415     


His Ala Met Val Asn Lys Leu His Cys Ser Val Thr Ile Ser Val Asp 
            420                 425                 430         


Gly Ile Leu Thr Thr Thr Gly Tyr Thr Gln Glu Asp Tyr Thr Met Leu 
        435                 440                 445             


Gly Ser Asp Asp Phe Phe Tyr Val Gly Gly Ser Pro Ser Thr Ala Asp 
    450                 455                 460                 


Leu Pro Gly Ser Pro Val Ser Asn Asn Phe Met Gly Cys Leu Lys Glu 
465                 470                 475                 480 


Val Val Tyr Lys Asn Asn Asp Val Arg Leu Glu Leu Ser Arg Leu Ala 
                485                 490                 495     


Lys Gln Gly Asp Pro Lys Met Lys Ile His Gly Val Val Ala Phe Lys 
            500                 505                 510         


Cys Glu Asn Val Ala Thr Leu Asp Pro Ile Thr Phe Glu Thr Pro Glu 
        515                 520                 525             


Ser Phe Ile Ser Leu Pro Lys Trp Asn Ala Lys Lys Thr Gly Ser Ile 
    530                 535                 540                 


Ser Phe Asp Phe Arg Thr Thr Glu Pro Asn Gly Leu Ile Leu Phe Ser 
545                 550                 555                 560 


His Gly Lys Pro Arg His Gln Lys Asp Ala Lys His Pro Gln Met Ile 
                565                 570                 575     


Lys Val Asp Phe Phe Ala Ile Glu Met Leu Asp Gly His Leu Tyr Leu 
            580                 585                 590         


Leu Leu Asp Met Gly Ser Gly Thr Ile Lys Ile Lys Ala Leu Leu Lys 
        595                 600                 605             


Lys Val Asn Asp Gly Glu Trp Tyr His Val Asp Phe Gln Arg Asp Gly 
    610                 615                 620                 


Arg Ser Gly Thr Ile Ser Val Asn Thr Leu Arg Thr Pro Tyr Thr Ala 
625                 630                 635                 640 


Pro Gly Glu Ser Glu Ile Leu Asp Leu Asp Asp Glu Leu Tyr Leu Gly 
                645                 650                 655     


Gly Leu Pro Glu Asn Lys Ala Gly Leu Val Phe Pro Thr Glu Val Trp 
            660                 665                 670         


Thr Ala Leu Leu Asn Tyr Gly Tyr Val Gly Cys Ile Arg Asp Leu Phe 
        675                 680                 685             


Ile Asp Gly Gln Ser Lys Asp Ile Arg Gln Met Ala Glu Val Gln Ser 
    690                 695                 700                 


Thr Ala Gly Val Lys Pro Ser Cys Ser Lys Glu Thr Ala Lys Pro Cys 
705                 710                 715                 720 


Leu Ser Asn Pro Cys Lys Asn Asn Gly Met Cys Arg Asp Gly Trp Asn 
                725                 730                 735     


Arg Tyr Val Cys Asp Cys Ser Gly Thr Gly Tyr Leu Gly Arg Ser Cys 
            740                 745                 750         


Glu Arg Glu Ala Thr Val Leu Ser Tyr Asp Gly Ser Met Phe Met Lys 
        755                 760                 765             


Ile Gln Leu Pro Val Val Met His Thr Glu Ala Glu Asp Val Ser Leu 
    770                 775                 780                 


Arg Phe Arg Ser Gln Arg Ala Tyr Gly Ile Leu Met Ala Thr Thr Ser 
785                 790                 795                 800 


Arg Asp Ser Ala Asp Thr Leu Arg Leu Glu Leu Asp Ala Gly Arg Val 
                805                 810                 815     


Lys Leu Thr Val Asn Leu Asp Cys Ile Arg Ile Asn Cys Asn Ser Ser 
            820                 825                 830         


Lys Gly Pro Glu Thr Leu Phe Ala Gly Tyr Asn Leu Asn Asp Asn Glu 
        835                 840                 845             


Trp His Thr Val Arg Val Val Arg Arg Gly Lys Ser Leu Lys Leu Thr 
    850                 855                 860                 


Val Asp Asp Gln Gln Ala Met Thr Gly Gln Met Ala Gly Asp His Thr 
865                 870                 875                 880 


Arg Leu Glu Phe His Asn Ile Glu Thr Gly Ile Ile Thr Glu Arg Arg 
                885                 890                 895     


Tyr Leu Ser Ser Val Pro Ser Asn Phe Ile Gly His Leu Gln Ser Leu 
            900                 905                 910         


Thr Phe Asn Gly Met Ala Tyr Ile Asp Leu Cys Lys Asn Gly Asp Ile 
        915                 920                 925             


Asp Tyr Cys Glu Leu Asn Ala Arg Phe Gly Phe Arg Asn Ile Ile Ala 
    930                 935                 940                 


Asp Pro Val Thr Phe Lys Thr Lys Ser Ser Tyr Val Ala Leu Ala Thr 
945                 950                 955                 960 


Leu Gln Ala Tyr Thr Ser Met His Leu Phe Phe Gln Phe Lys Thr Thr 
                965                 970                 975     


Ser Leu Asp Gly Leu Ile Leu Tyr Asn Ser Gly Asp Gly Asn Asp Phe 
            980                 985                 990         


Ile Val Val Glu Leu Val Lys Gly  Tyr Leu His Tyr Val  Phe Asp Leu 
        995                 1000                 1005             


Gly Asn  Gly Ala Asn Leu Ile  Lys Gly Ser Ser Asn  Lys Pro Leu 
    1010                 1015                 1020             


Asn Asp  Asn Gln Trp His Asn  Val Met Ile Ser Arg  Asp Thr Ser 
    1025                 1030                 1035             


Asn Leu  His Thr Val Lys Ile  Asp Thr Lys Ile Thr  Thr Gln Ile 
    1040                 1045                 1050             


Thr Ala  Gly Ala Arg Asn Leu  Asp Leu Lys Ser Asp  Leu Tyr Ile 
    1055                 1060                 1065             


Gly Gly  Val Ala Lys Glu Thr  Tyr Lys Ser Leu Pro  Lys Leu Val 
    1070                 1075                 1080             


His Ala  Lys Glu Gly Phe Gln  Gly Cys Leu Ala Ser  Val Asp Leu 
    1085                 1090                 1095             


Asn Gly  Arg Leu Pro Asp Leu  Ile Ser Asp Ala Leu  Phe Cys Asn 
    1100                 1105                 1110             


Gly Gln  Ile Glu Arg Gly Cys  Glu Gly Pro Ser Thr  Thr Cys Gln 
    1115                 1120                 1125             


Glu Asp  Ser Cys Ser Asn Gln  Gly Val Cys Leu Gln  Gln Trp Asp 
    1130                 1135                 1140             


Gly Phe  Ser Cys Asp Cys Ser  Met Thr Ser Phe Ser  Gly Pro Leu 
    1145                 1150                 1155             


Cys Asn  Asp Pro Gly Thr Thr  Tyr Ile Phe Ser Lys  Gly Gly Gly 
    1160                 1165                 1170             


Gln Ile  Thr Tyr Lys Trp Pro  Pro Asn Asp Arg Pro  Ser Thr Arg 
    1175                 1180                 1185             


Ala Asp  Arg Leu Ala Ile Gly  Phe Ser Thr Val Gln  Lys Glu Ala 
    1190                 1195                 1200             


Val Leu  Val Arg Val Asp Ser  Ser Ser Gly Leu Gly  Asp Tyr Leu 
    1205                 1210                 1215             


Glu Leu  His Ile His Gln Gly  Lys Ile Gly Val Lys  Phe Asn Val 
    1220                 1225                 1230             


Gly Thr  Asp Asp Ile Ala Ile  Glu Glu Ser Asn Ala  Ile Ile Asn 
    1235                 1240                 1245             


Asp Gly  Lys Tyr His Val Val  Arg Phe Thr Arg Ser  Gly Gly Asn 
    1250                 1255                 1260             


Ala Thr  Leu Gln Val Asp Ser  Trp Pro Val Ile Glu  Arg Tyr Pro 
    1265                 1270                 1275             


Ala Gly  Asn Asn Asp Asn Glu  Arg Leu Ala Ile Ala  Arg Gln Arg 
    1280                 1285                 1290             


Ile Pro  Tyr Arg Leu Gly Arg  Val Val Asp Glu Trp  Leu Leu Asp 
    1295                 1300                 1305             


Lys Gly  Arg Gln Leu Thr Ile  Phe Asn Ser Gln Ala  Thr Ile Ile 
    1310                 1315                 1320             


Ile Gly  Gly Lys Glu Gln Gly  Gln Pro Phe Gln Gly  Gln Leu Ser 
    1325                 1330                 1335             


Gly Leu  Tyr Tyr Asn Gly Leu  Lys Val Leu Asn Met  Ala Ala Glu 
    1340                 1345                 1350             


Asn Asp  Ala Asn Ile Ala Ile  Val Gly Asn Val Arg  Leu Val Gly 
    1355                 1360                 1365             


Glu Val  Pro Ser Ser Met Thr  Thr Glu Ser Thr Ala  Thr Ala Met 
    1370                 1375                 1380             


Gln Ser  Glu Met Ser Thr Ser  Ile Met Glu Thr Thr  Thr Thr Leu 
    1385                 1390                 1395             


Ala Thr  Ser Thr Ala Arg Arg  Gly Lys Pro Pro Thr  Lys Glu Pro 
    1400                 1405                 1410             


Ile Ser  Gln Thr Thr Asp Asp  Ile Leu Val Ala Ser  Ala Glu Cys 
    1415                 1420                 1425             


Pro Ser  Asp Asp Glu Asp Ile  Asp Pro Cys Glu Pro  Ser Ser Gly 
    1430                 1435                 1440             


Gly Leu  Ala Asn Pro Thr Arg  Ala Gly Gly Arg Glu  Pro Tyr Pro 
    1445                 1450                 1455             


Gly Ser  Ala Glu Val Ile Arg  Glu Ser Ser Ser Thr  Thr Gly Met 
    1460                 1465                 1470             


Val Val  Gly Ile Val Ala Ala  Ala Ala Leu Cys Ile  Leu Ile Leu 
    1475                 1480                 1485             


Leu Tyr  Ala Met Tyr Lys Tyr  Arg Asn Arg Asp Glu  Gly Ser Tyr 
    1490                 1495                 1500             


His Val  Asp Glu Ser Arg Asn  Tyr Ile Ser Asn Ser  Ala Gln Ser 
    1505                 1510                 1515             


Asn Gly  Ala Val Val Lys Glu  Lys Gln Pro Ser Ser  Ala Lys Ser 
    1520                 1525                 1530             


Ser Asn  Lys Asn Lys Lys Asn  Lys Asp Lys Glu Tyr  Tyr Val 
    1535                 1540                 1545         


<210>  9562
<211>  1495
<212>  PRT
<213>  Homo Sapiens

<400>  9562

Met Gly Thr Ala Leu Leu Gln Arg Gly Gly Cys Phe Leu Leu Cys Leu 
1               5                   10                  15      


Ser Leu Leu Leu Leu Gly Cys Trp Ala Glu Leu Gly Ser Gly Leu Glu 
            20                  25                  30          


Phe Pro Gly Ala Glu Gly Gln Trp Thr Arg Phe Pro Lys Trp Asn Ala 
        35                  40                  45              


Cys Cys Glu Ser Glu Met Ser Phe Gln Leu Lys Thr Arg Ser Ala Arg 
    50                  55                  60                  


Gly Leu Val Leu Tyr Phe Asp Asp Glu Gly Phe Cys Asp Phe Leu Glu 
65                  70                  75                  80  


Leu Ile Leu Thr Arg Gly Gly Arg Leu Gln Leu Ser Phe Ser Ile Phe 
                85                  90                  95      


Cys Ala Glu Pro Ala Thr Leu Leu Ala Asp Thr Pro Val Asn Asp Gly 
            100                 105                 110         


Ala Trp His Ser Val Arg Ile Arg Arg Gln Phe Arg Asn Thr Thr Leu 
        115                 120                 125             


Phe Ile Asp Gln Val Glu Ala Lys Trp Val Glu Val Lys Ser Lys Arg 
    130                 135                 140                 


Arg Asp Met Thr Val Phe Ser Gly Leu Phe Val Gly Gly Leu Pro Pro 
145                 150                 155                 160 


Glu Leu Arg Ala Ala Ala Leu Lys Leu Thr Leu Ala Ser Val Arg Glu 
                165                 170                 175     


Arg Glu Pro Phe Lys Gly Trp Ile Arg Asp Val Arg Val Asn Ser Ser 
            180                 185                 190         


Gln Val Leu Pro Val Asp Ser Gly Glu Val Lys Leu Asp Asp Glu Pro 
        195                 200                 205             


Pro Asn Ser Gly Gly Gly Ser Pro Cys Glu Ala Gly Glu Glu Gly Glu 
    210                 215                 220                 


Gly Gly Val Cys Leu Asn Gly Gly Val Cys Ser Val Val Asp Asp Gln 
225                 230                 235                 240 


Ala Val Cys Asp Cys Ser Arg Thr Gly Phe Arg Gly Lys Asp Cys Ser 
                245                 250                 255     


Gln Glu Asp Asn Asn Val Glu Gly Leu Ala His Leu Met Met Gly Asp 
            260                 265                 270         


Gln Gly Lys Glu Glu Tyr Ile Ala Thr Phe Lys Gly Ser Glu Tyr Phe 
        275                 280                 285             


Cys Tyr Asp Leu Ser Gln Asn Pro Ile Gln Ser Ser Ser Asp Glu Ile 
    290                 295                 300                 


Thr Leu Ser Phe Lys Thr Leu Gln Arg Asn Gly Leu Met Leu His Thr 
305                 310                 315                 320 


Gly Lys Ser Ala Asp Tyr Val Asn Leu Ala Leu Lys Asn Gly Ala Val 
                325                 330                 335     


Ser Leu Val Ile Asn Leu Gly Ser Gly Ala Phe Glu Ala Leu Val Glu 
            340                 345                 350         


Pro Val Asn Gly Lys Phe Asn Asp Asn Ala Trp His Asp Val Lys Val 
        355                 360                 365             


Thr Arg Asn Leu Arg Gln Val Thr Ile Ser Val Asp Gly Ile Leu Thr 
    370                 375                 380                 


Thr Thr Gly Tyr Thr Gln Glu Asp Tyr Thr Met Leu Gly Ser Asp Asp 
385                 390                 395                 400 


Phe Phe Tyr Val Gly Gly Ser Pro Ser Thr Ala Asp Leu Pro Gly Ser 
                405                 410                 415     


Pro Val Ser Asn Asn Phe Met Gly Cys Leu Lys Glu Val Val Tyr Lys 
            420                 425                 430         


Asn Asn Asp Val Arg Leu Glu Leu Ser Arg Leu Ala Lys Gln Gly Asp 
        435                 440                 445             


Pro Lys Met Lys Ile His Gly Val Val Ala Phe Lys Cys Glu Asn Val 
    450                 455                 460                 


Ala Thr Leu Asp Pro Ile Thr Phe Glu Thr Pro Glu Ser Phe Ile Ser 
465                 470                 475                 480 


Leu Pro Lys Trp Asn Ala Lys Lys Thr Gly Ser Ile Ser Phe Asp Phe 
                485                 490                 495     


Arg Thr Thr Glu Pro Asn Gly Leu Ile Leu Phe Ser His Gly Lys Pro 
            500                 505                 510         


Arg His Gln Lys Asp Ala Lys His Pro Gln Met Ile Lys Val Asp Phe 
        515                 520                 525             


Phe Ala Ile Glu Met Leu Asp Gly His Leu Tyr Leu Leu Leu Asp Met 
    530                 535                 540                 


Gly Ser Gly Thr Ile Lys Ile Lys Ala Leu Leu Lys Lys Val Asn Asp 
545                 550                 555                 560 


Gly Glu Trp Tyr His Val Asp Phe Gln Arg Asp Gly Arg Ser Gly Thr 
                565                 570                 575     


Ile Ser Val Asn Thr Leu Arg Thr Pro Tyr Thr Ala Pro Gly Glu Ser 
            580                 585                 590         


Glu Ile Leu Asp Leu Asp Asp Glu Leu Tyr Leu Gly Gly Leu Pro Glu 
        595                 600                 605             


Asn Lys Ala Gly Leu Val Phe Pro Thr Glu Val Trp Thr Ala Leu Leu 
    610                 615                 620                 


Asn Tyr Gly Tyr Val Gly Cys Ile Arg Asp Leu Phe Ile Asp Gly Gln 
625                 630                 635                 640 


Ser Lys Asp Ile Arg Gln Met Ala Glu Val Gln Ser Thr Ala Gly Val 
                645                 650                 655     


Lys Pro Ser Cys Ser Lys Glu Thr Ala Lys Pro Cys Leu Ser Asn Pro 
            660                 665                 670         


Cys Lys Asn Asn Gly Met Cys Arg Asp Gly Trp Asn Arg Tyr Val Cys 
        675                 680                 685             


Asp Cys Ser Gly Thr Gly Tyr Leu Gly Arg Ser Cys Glu Arg Glu Ala 
    690                 695                 700                 


Thr Val Leu Ser Tyr Asp Gly Ser Met Phe Met Lys Ile Gln Leu Pro 
705                 710                 715                 720 


Val Val Met His Thr Glu Ala Glu Asp Val Ser Leu Arg Phe Arg Ser 
                725                 730                 735     


Gln Arg Ala Tyr Gly Ile Leu Met Ala Thr Thr Ser Arg Asp Ser Ala 
            740                 745                 750         


Asp Thr Leu Arg Leu Glu Leu Asp Ala Gly Arg Val Lys Leu Thr Val 
        755                 760                 765             


Asn Leu Asp Cys Ile Arg Ile Asn Cys Asn Ser Ser Lys Gly Pro Glu 
    770                 775                 780                 


Thr Leu Phe Ala Gly Tyr Asn Leu Asn Asp Asn Glu Trp His Thr Val 
785                 790                 795                 800 


Arg Val Val Arg Arg Gly Lys Ser Leu Lys Leu Thr Val Asp Asp Gln 
                805                 810                 815     


Gln Ala Met Thr Gly Gln Met Ala Gly Asp His Thr Arg Leu Glu Phe 
            820                 825                 830         


His Asn Ile Glu Thr Gly Ile Ile Thr Glu Arg Arg Tyr Leu Ser Ser 
        835                 840                 845             


Val Pro Ser Asn Phe Ile Gly His Leu Gln Ser Leu Thr Phe Asn Gly 
    850                 855                 860                 


Met Ala Tyr Ile Asp Leu Cys Lys Asn Gly Asp Ile Asp Tyr Cys Glu 
865                 870                 875                 880 


Leu Asn Ala Arg Phe Gly Phe Arg Asn Ile Ile Ala Asp Pro Val Thr 
                885                 890                 895     


Phe Lys Thr Lys Ser Ser Tyr Val Ala Leu Ala Thr Leu Gln Ala Tyr 
            900                 905                 910         


Thr Ser Met His Leu Phe Phe Gln Phe Lys Thr Thr Ser Leu Asp Gly 
        915                 920                 925             


Leu Ile Leu Tyr Asn Ser Gly Asp Gly Asn Asp Phe Ile Val Val Glu 
    930                 935                 940                 


Leu Val Lys Gly Tyr Leu His Tyr Val Phe Asp Leu Gly Asn Gly Ala 
945                 950                 955                 960 


Asn Leu Ile Lys Gly Ser Ser Asn Lys Pro Leu Asn Asp Asn Gln Trp 
                965                 970                 975     


His Asn Val Met Ile Ser Arg Asp Thr Ser Asn Leu His Thr Val Lys 
            980                 985                 990         


Ile Asp Thr Lys Ile Thr Thr Gln  Ile Thr Ala Gly Ala  Arg Asn Leu 
        995                 1000                 1005             


Asp Leu  Lys Ser Asp Leu Tyr  Ile Gly Gly Val Ala  Lys Glu Thr 
    1010                 1015                 1020             


Tyr Lys  Ser Leu Pro Lys Leu  Val His Ala Lys Glu  Gly Phe Gln 
    1025                 1030                 1035             


Gly Cys  Leu Ala Ser Val Asp  Leu Asn Gly Arg Leu  Pro Asp Leu 
    1040                 1045                 1050             


Ile Ser  Asp Ala Leu Phe Cys  Asn Gly Gln Ile Glu  Arg Gly Cys 
    1055                 1060                 1065             


Glu Gly  Pro Ser Thr Thr Cys  Gln Glu Asp Ser Cys  Ser Asn Gln 
    1070                 1075                 1080             


Gly Val  Cys Leu Gln Gln Trp  Asp Gly Phe Ser Cys  Asp Cys Ser 
    1085                 1090                 1095             


Met Thr  Ser Phe Ser Gly Pro  Leu Cys Asn Asp Pro  Gly Thr Thr 
    1100                 1105                 1110             


Tyr Ile  Phe Ser Lys Gly Gly  Gly Gln Ile Thr Tyr  Lys Trp Pro 
    1115                 1120                 1125             


Pro Asn  Asp Arg Pro Ser Thr  Arg Ala Asp Arg Leu  Ala Ile Gly 
    1130                 1135                 1140             


Phe Ser  Thr Val Gln Lys Glu  Ala Val Leu Val Arg  Val Asp Ser 
    1145                 1150                 1155             


Ser Ser  Gly Leu Gly Asp Tyr  Leu Glu Leu His Ile  His Gln Gly 
    1160                 1165                 1170             


Lys Ile  Gly Val Lys Phe Asn  Val Gly Thr Asp Asp  Ile Ala Ile 
    1175                 1180                 1185             


Glu Glu  Ser Asn Ala Ile Ile  Asn Asp Gly Lys Tyr  His Val Val 
    1190                 1195                 1200             


Arg Phe  Thr Arg Ser Gly Gly  Asn Ala Thr Leu Gln  Val Asp Ser 
    1205                 1210                 1215             


Trp Pro  Val Ile Glu Arg Tyr  Pro Ala Gly Asn Asn  Asp Asn Glu 
    1220                 1225                 1230             


Arg Leu  Ala Ile Ala Arg Gln  Arg Ile Pro Tyr Arg  Leu Gly Arg 
    1235                 1240                 1245             


Val Val  Asp Glu Trp Leu Leu  Asp Lys Gly Arg Gln  Leu Thr Ile 
    1250                 1255                 1260             


Phe Asn  Ser Gln Ala Thr Ile  Ile Ile Gly Gly Lys  Glu Gln Gly 
    1265                 1270                 1275             


Gln Pro  Phe Gln Gly Gln Leu  Ser Gly Leu Tyr Tyr  Asn Gly Leu 
    1280                 1285                 1290             


Lys Val  Leu Asn Met Ala Ala  Glu Asn Asp Ala Asn  Ile Ala Ile 
    1295                 1300                 1305             


Val Gly  Asn Val Arg Leu Val  Gly Glu Val Pro Ser  Ser Met Thr 
    1310                 1315                 1320             


Thr Glu  Ser Thr Ala Thr Ala  Met Gln Ser Glu Met  Ser Thr Ser 
    1325                 1330                 1335             


Ile Met  Glu Thr Thr Thr Thr  Leu Ala Thr Ser Thr  Ala Arg Arg 
    1340                 1345                 1350             


Gly Lys  Pro Pro Thr Lys Glu  Pro Ile Ser Gln Thr  Thr Asp Asp 
    1355                 1360                 1365             


Ile Leu  Val Ala Ser Ala Glu  Cys Pro Ser Asp Asp  Glu Asp Ile 
    1370                 1375                 1380             


Asp Pro  Cys Glu Pro Ser Ser  Gly Gly Leu Ala Asn  Pro Thr Arg 
    1385                 1390                 1395             


Ala Gly  Gly Arg Glu Pro Tyr  Pro Gly Ser Ala Glu  Val Ile Arg 
    1400                 1405                 1410             


Glu Ser  Ser Ser Thr Thr Gly  Met Val Val Gly Ile  Val Ala Ala 
    1415                 1420                 1425             


Ala Ala  Leu Cys Ile Leu Ile  Leu Leu Tyr Ala Met  Tyr Lys Tyr 
    1430                 1435                 1440             


Arg Asn  Arg Asp Glu Gly Ser  Tyr His Val Asp Glu  Ser Arg Asn 
    1445                 1450                 1455             


Tyr Ile  Ser Asn Ser Ala Gln  Ser Asn Gly Ala Val  Val Lys Glu 
    1460                 1465                 1470             


Lys Gln  Pro Ser Ser Ala Lys  Ser Ser Asn Lys Asn  Lys Lys Asn 
    1475                 1480                 1485             


Lys Asp  Lys Glu Tyr Tyr Val  
    1490                 1495 


<210>  9563
<211>  1507
<212>  PRT
<213>  Homo Sapiens

<400>  9563

Met Gly Thr Ala Leu Leu Gln Arg Gly Gly Cys Phe Leu Leu Cys Leu 
1               5                   10                  15      


Ser Leu Leu Leu Leu Gly Cys Trp Ala Glu Leu Gly Ser Gly Leu Glu 
            20                  25                  30          


Phe Pro Gly Ala Glu Gly Gln Trp Thr Arg Phe Pro Lys Trp Asn Ala 
        35                  40                  45              


Cys Cys Glu Ser Glu Met Ser Phe Gln Leu Lys Thr Arg Ser Ala Arg 
    50                  55                  60                  


Gly Leu Val Leu Tyr Phe Asp Asp Glu Gly Phe Cys Asp Phe Leu Glu 
65                  70                  75                  80  


Leu Ile Leu Thr Arg Gly Gly Arg Leu Gln Leu Ser Phe Ser Ile Phe 
                85                  90                  95      


Cys Ala Glu Pro Ala Thr Leu Leu Ala Asp Thr Pro Val Asn Asp Gly 
            100                 105                 110         


Ala Trp His Ser Val Arg Ile Arg Arg Gln Phe Arg Asn Thr Thr Leu 
        115                 120                 125             


Phe Ile Asp Gln Val Glu Ala Lys Trp Val Glu Val Lys Ser Lys Arg 
    130                 135                 140                 


Arg Asp Met Thr Val Phe Ser Gly Leu Phe Val Gly Gly Leu Pro Pro 
145                 150                 155                 160 


Glu Leu Arg Ala Ala Ala Leu Lys Leu Thr Leu Ala Ser Val Arg Glu 
                165                 170                 175     


Arg Glu Pro Phe Lys Gly Trp Ile Arg Asp Val Arg Val Asn Ser Ser 
            180                 185                 190         


Gln Val Leu Pro Val Asp Ser Gly Glu Val Lys Leu Asp Asp Glu Pro 
        195                 200                 205             


Pro Asn Ser Gly Gly Gly Ser Pro Cys Glu Ala Gly Glu Glu Gly Glu 
    210                 215                 220                 


Gly Gly Val Cys Leu Asn Gly Gly Val Cys Ser Val Val Asp Asp Gln 
225                 230                 235                 240 


Ala Val Cys Asp Cys Ser Arg Thr Gly Phe Arg Gly Lys Asp Cys Ser 
                245                 250                 255     


Gln Glu Asp Asn Asn Val Glu Gly Leu Ala His Leu Met Met Gly Asp 
            260                 265                 270         


Gln Gly Lys Ser Lys Gly Lys Glu Glu Tyr Ile Ala Thr Phe Lys Gly 
        275                 280                 285             


Ser Glu Tyr Phe Cys Tyr Asp Leu Ser Gln Asn Pro Ile Gln Ser Ser 
    290                 295                 300                 


Ser Asp Glu Ile Thr Leu Ser Phe Lys Thr Leu Gln Arg Asn Gly Leu 
305                 310                 315                 320 


Met Leu His Thr Gly Lys Ser Ala Asp Tyr Val Asn Leu Ala Leu Lys 
                325                 330                 335     


Asn Gly Ala Val Ser Leu Val Ile Asn Leu Gly Ser Gly Ala Phe Glu 
            340                 345                 350         


Ala Leu Val Glu Pro Val Asn Gly Lys Phe Asn Asp Asn Ala Trp His 
        355                 360                 365             


Asp Val Lys Val Thr Arg Asn Leu Arg Gln His Ser Gly Ile Gly His 
    370                 375                 380                 


Ala Met Val Thr Ile Ser Val Asp Gly Ile Leu Thr Thr Thr Gly Tyr 
385                 390                 395                 400 


Thr Gln Glu Asp Tyr Thr Met Leu Gly Ser Asp Asp Phe Phe Tyr Val 
                405                 410                 415     


Gly Gly Ser Pro Ser Thr Ala Asp Leu Pro Gly Ser Pro Val Ser Asn 
            420                 425                 430         


Asn Phe Met Gly Cys Leu Lys Glu Val Val Tyr Lys Asn Asn Asp Val 
        435                 440                 445             


Arg Leu Glu Leu Ser Arg Leu Ala Lys Gln Gly Asp Pro Lys Met Lys 
    450                 455                 460                 


Ile His Gly Val Val Ala Phe Lys Cys Glu Asn Val Ala Thr Leu Asp 
465                 470                 475                 480 


Pro Ile Thr Phe Glu Thr Pro Glu Ser Phe Ile Ser Leu Pro Lys Trp 
                485                 490                 495     


Asn Ala Lys Lys Thr Gly Ser Ile Ser Phe Asp Phe Arg Thr Thr Glu 
            500                 505                 510         


Pro Asn Gly Leu Ile Leu Phe Ser His Gly Lys Pro Arg His Gln Lys 
        515                 520                 525             


Asp Ala Lys His Pro Gln Met Ile Lys Val Asp Phe Phe Ala Ile Glu 
    530                 535                 540                 


Met Leu Asp Gly His Leu Tyr Leu Leu Leu Asp Met Gly Ser Gly Thr 
545                 550                 555                 560 


Ile Lys Ile Lys Ala Leu Leu Lys Lys Val Asn Asp Gly Glu Trp Tyr 
                565                 570                 575     


His Val Asp Phe Gln Arg Asp Gly Arg Ser Gly Thr Ile Ser Val Asn 
            580                 585                 590         


Thr Leu Arg Thr Pro Tyr Thr Ala Pro Gly Glu Ser Glu Ile Leu Asp 
        595                 600                 605             


Leu Asp Asp Glu Leu Tyr Leu Gly Gly Leu Pro Glu Asn Lys Ala Gly 
    610                 615                 620                 


Leu Val Phe Pro Thr Glu Val Trp Thr Ala Leu Leu Asn Tyr Gly Tyr 
625                 630                 635                 640 


Val Gly Cys Ile Arg Asp Leu Phe Ile Asp Gly Gln Ser Lys Asp Ile 
                645                 650                 655     


Arg Gln Met Ala Glu Val Gln Ser Thr Ala Gly Val Lys Pro Ser Cys 
            660                 665                 670         


Ser Lys Glu Thr Ala Lys Pro Cys Leu Ser Asn Pro Cys Lys Asn Asn 
        675                 680                 685             


Gly Met Cys Arg Asp Gly Trp Asn Arg Tyr Val Cys Asp Cys Ser Gly 
    690                 695                 700                 


Thr Gly Tyr Leu Gly Arg Ser Cys Glu Arg Glu Ala Thr Val Leu Ser 
705                 710                 715                 720 


Tyr Asp Gly Ser Met Phe Met Lys Ile Gln Leu Pro Val Val Met His 
                725                 730                 735     


Thr Glu Ala Glu Asp Val Ser Leu Arg Phe Arg Ser Gln Arg Ala Tyr 
            740                 745                 750         


Gly Ile Leu Met Ala Thr Thr Ser Arg Asp Ser Ala Asp Thr Leu Arg 
        755                 760                 765             


Leu Glu Leu Asp Ala Gly Arg Val Lys Leu Thr Val Asn Leu Asp Cys 
    770                 775                 780                 


Ile Arg Ile Asn Cys Asn Ser Ser Lys Gly Pro Glu Thr Leu Phe Ala 
785                 790                 795                 800 


Gly Tyr Asn Leu Asn Asp Asn Glu Trp His Thr Val Arg Val Val Arg 
                805                 810                 815     


Arg Gly Lys Ser Leu Lys Leu Thr Val Asp Asp Gln Gln Ala Met Thr 
            820                 825                 830         


Gly Gln Met Ala Gly Asp His Thr Arg Leu Glu Phe His Asn Ile Glu 
        835                 840                 845             


Thr Gly Ile Ile Thr Glu Arg Arg Tyr Leu Ser Ser Val Pro Ser Asn 
    850                 855                 860                 


Phe Ile Gly His Leu Gln Ser Leu Thr Phe Asn Gly Met Ala Tyr Ile 
865                 870                 875                 880 


Asp Leu Cys Lys Asn Gly Asp Ile Asp Tyr Cys Glu Leu Asn Ala Arg 
                885                 890                 895     


Phe Gly Phe Arg Asn Ile Ile Ala Asp Pro Val Thr Phe Lys Thr Lys 
            900                 905                 910         


Ser Ser Tyr Val Ala Leu Ala Thr Leu Gln Ala Tyr Thr Ser Met His 
        915                 920                 925             


Leu Phe Phe Gln Phe Lys Thr Thr Ser Leu Asp Gly Leu Ile Leu Tyr 
    930                 935                 940                 


Asn Ser Gly Asp Gly Asn Asp Phe Ile Val Val Glu Leu Val Lys Gly 
945                 950                 955                 960 


Tyr Leu His Tyr Val Phe Asp Leu Gly Asn Gly Ala Asn Leu Ile Lys 
                965                 970                 975     


Gly Ser Ser Asn Lys Pro Leu Asn Asp Asn Gln Trp His Asn Val Met 
            980                 985                 990         


Ile Ser Arg Asp Thr Ser Asn Leu  His Thr Val Lys Ile  Asp Thr Lys 
        995                 1000                 1005             


Ile Thr  Thr Gln Ile Thr Ala  Gly Ala Arg Asn Leu  Asp Leu Lys 
    1010                 1015                 1020             


Ser Asp  Leu Tyr Ile Gly Gly  Val Ala Lys Glu Thr  Tyr Lys Ser 
    1025                 1030                 1035             


Leu Pro  Lys Leu Val His Ala  Lys Glu Gly Phe Gln  Gly Cys Leu 
    1040                 1045                 1050             


Ala Ser  Val Asp Leu Asn Gly  Arg Leu Pro Asp Leu  Ile Ser Asp 
    1055                 1060                 1065             


Ala Leu  Phe Cys Asn Gly Gln  Ile Glu Arg Gly Cys  Glu Gly Pro 
    1070                 1075                 1080             


Ser Thr  Thr Cys Gln Glu Asp  Ser Cys Ser Asn Gln  Gly Val Cys 
    1085                 1090                 1095             


Leu Gln  Gln Trp Asp Gly Phe  Ser Cys Asp Cys Ser  Met Thr Ser 
    1100                 1105                 1110             


Phe Ser  Gly Pro Leu Cys Asn  Asp Pro Gly Thr Thr  Tyr Ile Phe 
    1115                 1120                 1125             


Ser Lys  Gly Gly Gly Gln Ile  Thr Tyr Lys Trp Pro  Pro Asn Asp 
    1130                 1135                 1140             


Arg Pro  Ser Thr Arg Ala Asp  Arg Leu Ala Ile Gly  Phe Ser Thr 
    1145                 1150                 1155             


Val Gln  Lys Glu Ala Val Leu  Val Arg Val Asp Ser  Ser Ser Gly 
    1160                 1165                 1170             


Leu Gly  Asp Tyr Leu Glu Leu  His Ile His Gln Gly  Lys Ile Gly 
    1175                 1180                 1185             


Val Lys  Phe Asn Val Gly Thr  Asp Asp Ile Ala Ile  Glu Glu Ser 
    1190                 1195                 1200             


Asn Ala  Ile Ile Asn Asp Gly  Lys Tyr His Val Val  Arg Phe Thr 
    1205                 1210                 1215             


Arg Ser  Gly Gly Asn Ala Thr  Leu Gln Val Asp Ser  Trp Pro Val 
    1220                 1225                 1230             


Ile Glu  Arg Tyr Pro Ala Gly  Asn Asn Asp Asn Glu  Arg Leu Ala 
    1235                 1240                 1245             


Ile Ala  Arg Gln Arg Ile Pro  Tyr Arg Leu Gly Arg  Val Val Asp 
    1250                 1255                 1260             


Glu Trp  Leu Leu Asp Lys Gly  Arg Gln Leu Thr Ile  Phe Asn Ser 
    1265                 1270                 1275             


Gln Ala  Thr Ile Ile Ile Gly  Gly Lys Glu Gln Gly  Gln Pro Phe 
    1280                 1285                 1290             


Gln Gly  Gln Leu Ser Gly Leu  Tyr Tyr Asn Gly Leu  Lys Val Leu 
    1295                 1300                 1305             


Asn Met  Ala Ala Glu Asn Asp  Ala Asn Ile Ala Ile  Val Gly Asn 
    1310                 1315                 1320             


Val Arg  Leu Val Gly Glu Val  Pro Ser Ser Met Thr  Thr Glu Ser 
    1325                 1330                 1335             


Thr Ala  Thr Ala Met Gln Ser  Glu Met Ser Thr Ser  Ile Met Glu 
    1340                 1345                 1350             


Thr Thr  Thr Thr Leu Ala Thr  Ser Thr Ala Arg Arg  Gly Lys Pro 
    1355                 1360                 1365             


Pro Thr  Lys Glu Pro Ile Ser  Gln Thr Thr Asp Asp  Ile Leu Val 
    1370                 1375                 1380             


Ala Ser  Ala Glu Cys Pro Ser  Asp Asp Glu Asp Ile  Asp Pro Cys 
    1385                 1390                 1395             


Glu Pro  Ser Ser Gly Gly Leu  Ala Asn Pro Thr Arg  Ala Gly Gly 
    1400                 1405                 1410             


Arg Glu  Pro Tyr Pro Gly Ser  Ala Glu Val Ile Arg  Glu Ser Ser 
    1415                 1420                 1425             


Ser Thr  Thr Gly Met Val Val  Gly Ile Val Ala Ala  Ala Ala Leu 
    1430                 1435                 1440             


Cys Ile  Leu Ile Leu Leu Tyr  Ala Met Tyr Lys Tyr  Arg Asn Arg 
    1445                 1450                 1455             


Asp Glu  Gly Ser Tyr His Val  Asp Glu Ser Arg Asn  Tyr Ile Ser 
    1460                 1465                 1470             


Asn Ser  Ala Gln Ser Asn Gly  Ala Val Val Lys Glu  Lys Gln Pro 
    1475                 1480                 1485             


Ser Ser  Ala Lys Ser Ser Asn  Lys Asn Lys Lys Asn  Lys Asp Lys 
    1490                 1495                 1500             


Glu Tyr  Tyr Val 
    1505         


<210>  9564
<211>  1496
<212>  PRT
<213>  Homo Sapiens

<400>  9564

Met Gly Thr Ala Leu Leu Gln Arg Gly Gly Cys Phe Leu Leu Cys Leu 
1               5                   10                  15      


Ser Leu Leu Leu Leu Gly Cys Trp Ala Glu Leu Gly Ser Gly Leu Glu 
            20                  25                  30          


Phe Pro Gly Ala Glu Gly Gln Trp Thr Arg Phe Pro Lys Trp Asn Ala 
        35                  40                  45              


Cys Cys Glu Ser Glu Met Ser Phe Gln Leu Lys Thr Arg Ser Ala Arg 
    50                  55                  60                  


Gly Leu Val Leu Tyr Phe Asp Asp Glu Gly Phe Cys Asp Phe Leu Glu 
65                  70                  75                  80  


Leu Ile Leu Thr Arg Gly Gly Arg Leu Gln Leu Ser Phe Ser Ile Phe 
                85                  90                  95      


Cys Ala Glu Pro Ala Thr Leu Leu Ala Asp Thr Pro Val Asn Asp Gly 
            100                 105                 110         


Ala Trp His Ser Val Arg Ile Arg Arg Gln Phe Arg Asn Thr Thr Leu 
        115                 120                 125             


Phe Ile Asp Gln Val Glu Ala Lys Trp Val Glu Val Lys Ser Lys Arg 
    130                 135                 140                 


Arg Asp Met Thr Val Phe Ser Gly Leu Phe Val Gly Gly Leu Pro Pro 
145                 150                 155                 160 


Glu Leu Arg Ala Ala Ala Leu Lys Leu Thr Leu Ala Ser Val Arg Glu 
                165                 170                 175     


Arg Glu Pro Phe Lys Gly Trp Ile Arg Asp Val Arg Val Asn Ser Ser 
            180                 185                 190         


Gln Val Leu Pro Val Asp Ser Gly Glu Val Lys Leu Asp Asp Glu Pro 
        195                 200                 205             


Pro Asn Ser Gly Gly Gly Ser Pro Cys Glu Ala Gly Glu Glu Gly Glu 
    210                 215                 220                 


Gly Gly Val Cys Leu Asn Gly Gly Val Cys Ser Val Val Asp Asp Gln 
225                 230                 235                 240 


Ala Val Cys Asp Cys Ser Arg Thr Gly Phe Arg Gly Lys Asp Cys Ser 
                245                 250                 255     


Gln Glu Asp Asn Asn Val Glu Gly Leu Ala His Leu Met Met Gly Asp 
            260                 265                 270         


Gln Gly Lys Ser Lys Gly Lys Glu Glu Tyr Ile Ala Thr Phe Lys Gly 
        275                 280                 285             


Ser Glu Tyr Phe Cys Tyr Asp Leu Ser Gln Asn Pro Ile Gln Ser Ser 
    290                 295                 300                 


Ser Asp Glu Ile Thr Leu Ser Phe Lys Thr Leu Gln Arg Asn Gly Leu 
305                 310                 315                 320 


Met Leu His Thr Gly Lys Ser Ala Asp Tyr Val Asn Leu Ala Leu Lys 
                325                 330                 335     


Asn Gly Ala Val Ser Leu Val Ile Asn Leu Gly Ser Gly Ala Phe Glu 
            340                 345                 350         


Ala Leu Val Glu Pro Val Asn Gly Lys Phe Asn Asp Asn Ala Trp His 
        355                 360                 365             


Asp Val Lys Val Thr Arg Asn Leu Arg Gln Val Thr Ile Ser Val Asp 
    370                 375                 380                 


Gly Ile Leu Thr Thr Thr Gly Tyr Thr Gln Glu Asp Tyr Thr Met Leu 
385                 390                 395                 400 


Gly Ser Asp Asp Phe Phe Tyr Val Gly Gly Ser Pro Ser Thr Ala Asp 
                405                 410                 415     


Leu Pro Gly Ser Pro Val Ser Asn Asn Phe Met Gly Cys Leu Lys Glu 
            420                 425                 430         


Val Val Tyr Lys Asn Asn Asp Val Arg Leu Glu Leu Ser Arg Leu Ala 
        435                 440                 445             


Lys Gln Gly Asp Pro Lys Met Lys Ile His Gly Val Val Ala Phe Lys 
    450                 455                 460                 


Cys Glu Asn Val Ala Thr Leu Asp Pro Ile Thr Phe Glu Thr Pro Glu 
465                 470                 475                 480 


Ser Phe Ile Ser Leu Pro Lys Trp Asn Ala Lys Lys Thr Gly Ser Ile 
                485                 490                 495     


Ser Phe Asp Phe Arg Thr Thr Glu Pro Asn Gly Leu Ile Leu Phe Ser 
            500                 505                 510         


His Gly Lys Pro Arg His Gln Lys Asp Ala Lys His Pro Gln Met Ile 
        515                 520                 525             


Lys Val Asp Phe Phe Ala Ile Glu Met Leu Asp Gly His Leu Tyr Leu 
    530                 535                 540                 


Leu Leu Asp Met Gly Ser Gly Thr Ile Lys Ile Lys Ala Leu Leu Lys 
545                 550                 555                 560 


Lys Val Asn Asp Gly Glu Trp Tyr His Val Asp Phe Gln Arg Asp Gly 
                565                 570                 575     


Arg Ser Gly Thr Ile Ser Val Asn Thr Leu Arg Thr Pro Tyr Thr Ala 
            580                 585                 590         


Pro Gly Glu Ser Glu Ile Leu Asp Leu Asp Asp Glu Leu Tyr Leu Gly 
        595                 600                 605             


Gly Leu Pro Glu Asn Lys Ala Gly Leu Val Phe Pro Thr Glu Val Trp 
    610                 615                 620                 


Thr Ala Leu Leu Asn Tyr Gly Tyr Val Gly Cys Ile Arg Asp Leu Phe 
625                 630                 635                 640 


Ile Asp Gly Gln Ser Lys Asp Ile Arg Gln Met Ala Glu Val Gln Ser 
                645                 650                 655     


Thr Ala Gly Val Lys Pro Ser Cys Ser Lys Glu Thr Ala Lys Pro Cys 
            660                 665                 670         


Leu Ser Asn Pro Cys Lys Asn Asn Gly Met Cys Arg Asp Gly Trp Asn 
        675                 680                 685             


Arg Tyr Val Cys Asp Cys Ser Gly Thr Gly Tyr Leu Gly Arg Ser Cys 
    690                 695                 700                 


Glu Arg Glu Ala Thr Val Leu Ser Tyr Asp Gly Ser Met Phe Met Lys 
705                 710                 715                 720 


Ile Gln Leu Pro Val Val Met His Thr Glu Ala Glu Asp Val Ser Leu 
                725                 730                 735     


Arg Phe Arg Ser Gln Arg Ala Tyr Gly Ile Leu Met Ala Thr Thr Ser 
            740                 745                 750         


Arg Asp Ser Ala Asp Thr Leu Arg Leu Glu Leu Asp Ala Gly Arg Val 
        755                 760                 765             


Lys Leu Thr Val Asn Leu Asp Cys Ile Arg Ile Asn Cys Asn Ser Ser 
    770                 775                 780                 


Lys Gly Pro Glu Thr Leu Phe Ala Gly Tyr Asn Leu Asn Asp Asn Glu 
785                 790                 795                 800 


Trp His Thr Val Arg Val Val Arg Arg Gly Lys Ser Leu Lys Leu Thr 
                805                 810                 815     


Val Asp Asp Gln Gln Ala Met Thr Gly Gln Met Ala Gly Asp His Thr 
            820                 825                 830         


Arg Leu Glu Phe His Asn Ile Glu Thr Gly Ile Ile Thr Glu Arg Arg 
        835                 840                 845             


Tyr Leu Ser Ser Val Pro Ser Asn Phe Ile Gly His Leu Gln Ser Leu 
    850                 855                 860                 


Thr Phe Asn Gly Met Ala Tyr Ile Asp Leu Cys Lys Asn Gly Asp Ile 
865                 870                 875                 880 


Asp Tyr Cys Glu Leu Asn Ala Arg Phe Gly Phe Arg Asn Ile Ile Ala 
                885                 890                 895     


Asp Pro Val Thr Phe Lys Thr Lys Ser Ser Tyr Val Ala Leu Ala Thr 
            900                 905                 910         


Leu Gln Ala Tyr Thr Ser Met His Leu Phe Phe Gln Phe Lys Thr Thr 
        915                 920                 925             


Ser Leu Asp Gly Leu Ile Leu Tyr Asn Ser Gly Asp Gly Asn Asp Phe 
    930                 935                 940                 


Ile Val Val Glu Leu Val Lys Gly Tyr Leu His Tyr Val Phe Asp Leu 
945                 950                 955                 960 


Gly Asn Gly Ala Asn Leu Ile Lys Gly Ser Ser Asn Lys Pro Leu Asn 
                965                 970                 975     


Asp Asn Gln Trp His Asn Val Met Ile Ser Arg Asp Thr Ser Asn Leu 
            980                 985                 990         


His Thr Val Lys Ile Asp Thr Lys  Ile Thr Thr Gln Ile  Thr Ala Gly 
        995                 1000                 1005             


Ala Arg  Asn Leu Asp Leu Lys  Ser Asp Leu Tyr Ile  Gly Gly Val 
    1010                 1015                 1020             


Ala Lys  Glu Thr Tyr Lys Ser  Leu Pro Lys Leu Val  His Ala Lys 
    1025                 1030                 1035             


Glu Gly  Phe Gln Gly Cys Leu  Ala Ser Val Asp Leu  Asn Gly Arg 
    1040                 1045                 1050             


Leu Pro  Asp Leu Ile Ser Asp  Ala Leu Phe Cys Asn  Gly Gln Ile 
    1055                 1060                 1065             


Glu Arg  Gly Cys Glu Gly Pro  Ser Thr Thr Cys Gln  Glu Asp Ser 
    1070                 1075                 1080             


Cys Ser  Asn Gln Gly Val Cys  Leu Gln Gln Trp Asp  Gly Phe Ser 
    1085                 1090                 1095             


Cys Asp  Cys Ser Met Thr Ser  Phe Ser Gly Pro Leu  Cys Asn Asp 
    1100                 1105                 1110             


Pro Gly  Thr Thr Tyr Ile Phe  Ser Lys Gly Gly Gly  Gln Ile Thr 
    1115                 1120                 1125             


Tyr Lys  Trp Pro Pro Asn Asp  Arg Pro Ser Thr Arg  Ala Asp Arg 
    1130                 1135                 1140             


Leu Ala  Ile Gly Phe Ser Thr  Val Gln Lys Glu Ala  Val Leu Val 
    1145                 1150                 1155             


Arg Val  Asp Ser Ser Ser Gly  Leu Gly Asp Tyr Leu  Glu Leu His 
    1160                 1165                 1170             


Ile His  Gln Gly Lys Ile Gly  Val Lys Phe Asn Val  Gly Thr Asp 
    1175                 1180                 1185             


Asp Ile  Ala Ile Glu Glu Ser  Asn Ala Ile Ile Asn  Asp Gly Lys 
    1190                 1195                 1200             


Tyr His  Val Val Arg Phe Thr  Arg Ser Gly Gly Asn  Ala Thr Leu 
    1205                 1210                 1215             


Gln Val  Asp Ser Trp Pro Val  Ile Glu Arg Tyr Pro  Ala Gly Asn 
    1220                 1225                 1230             


Asn Asp  Asn Glu Arg Leu Ala  Ile Ala Arg Gln Arg  Ile Pro Tyr 
    1235                 1240                 1245             


Arg Leu  Gly Arg Val Val Asp  Glu Trp Leu Leu Asp  Lys Gly Arg 
    1250                 1255                 1260             


Gln Leu  Thr Ile Phe Asn Ser  Gln Ala Thr Ile Ile  Ile Gly Gly 
    1265                 1270                 1275             


Lys Glu  Gln Gly Gln Pro Phe  Gln Gly Gln Leu Ser  Gly Leu Tyr 
    1280                 1285                 1290             


Tyr Asn  Gly Leu Lys Val Leu  Asn Met Ala Ala Glu  Asn Asp Ala 
    1295                 1300                 1305             


Asn Ile  Ala Ile Val Gly Asn  Val Arg Leu Val Gly  Glu Val Pro 
    1310                 1315                 1320             


Ser Ser  Met Thr Thr Glu Ser  Thr Ala Thr Ala Met  Gln Ser Glu 
    1325                 1330                 1335             


Met Ser  Thr Ser Ile Met Glu  Thr Thr Thr Thr Leu  Ala Thr Ser 
    1340                 1345                 1350             


Thr Ala  Arg Arg Gly Lys Pro  Pro Thr Lys Glu Pro  Ile Ser Gln 
    1355                 1360                 1365             


Thr Thr  Asp Asp Ile Leu Val  Ala Ser Ala Glu Cys  Pro Ser Asp 
    1370                 1375                 1380             


Asp Glu  Asp Ile Asp Pro Cys  Glu Pro Ser Ser Ala  Asn Pro Thr 
    1385                 1390                 1395             


Arg Ala  Gly Gly Arg Glu Pro  Tyr Pro Gly Ser Ala  Glu Val Ile 
    1400                 1405                 1410             


Arg Glu  Ser Ser Ser Thr Thr  Gly Met Val Val Gly  Ile Val Ala 
    1415                 1420                 1425             


Ala Ala  Ala Leu Cys Ile Leu  Ile Leu Leu Tyr Ala  Met Tyr Lys 
    1430                 1435                 1440             


Tyr Arg  Asn Arg Asp Glu Gly  Ser Tyr His Val Asp  Glu Ser Arg 
    1445                 1450                 1455             


Asn Tyr  Ile Ser Asn Ser Ala  Gln Ser Asn Gly Ala  Val Val Lys 
    1460                 1465                 1470             


Glu Lys  Gln Pro Ser Ser Ala  Lys Ser Ser Asn Lys  Asn Lys Lys 
    1475                 1480                 1485             


Asn Lys  Asp Lys Glu Tyr Tyr  Val 
    1490                 1495     


<210>  9565
<211>  459
<212>  PRT
<213>  Homo Sapiens

<400>  9565

Met Gly Thr Ala Leu Leu Gln Arg Gly Gly Cys Phe Leu Leu Cys Leu 
1               5                   10                  15      


Ser Leu Leu Leu Leu Gly Cys Trp Ala Glu Leu Gly Ser Gly Leu Glu 
            20                  25                  30          


Phe Pro Gly Ala Glu Gly Gln Trp Thr Arg Phe Pro Lys Trp Asn Ala 
        35                  40                  45              


Cys Cys Glu Ser Glu Met Ser Phe Gln Leu Lys Thr Arg Ser Ala Arg 
    50                  55                  60                  


Gly Leu Val Leu Tyr Phe Asp Asp Glu Gly Phe Cys Asp Phe Leu Glu 
65                  70                  75                  80  


Leu Ile Leu Thr Arg Gly Gly Arg Leu Gln Leu Ser Phe Ser Ile Phe 
                85                  90                  95      


Cys Ala Glu Pro Ala Thr Leu Leu Ala Asp Thr Pro Val Asn Asp Gly 
            100                 105                 110         


Ala Trp His Ser Val Arg Ile Arg Arg Gln Phe Arg Asn Thr Thr Leu 
        115                 120                 125             


Phe Ile Asp Gln Val Glu Ala Lys Trp Val Glu Val Lys Ser Lys Arg 
    130                 135                 140                 


Arg Asp Met Thr Val Phe Ser Gly Leu Phe Val Gly Gly Leu Pro Pro 
145                 150                 155                 160 


Glu Leu Arg Ala Ala Ala Leu Lys Leu Thr Leu Ala Ser Val Arg Glu 
                165                 170                 175     


Arg Glu Pro Phe Lys Gly Trp Ile Arg Asp Val Arg Val Asn Ser Ser 
            180                 185                 190         


Gln Val Leu Pro Val Asp Ser Gly Glu Val Lys Leu Asp Asp Glu Pro 
        195                 200                 205             


Pro Asn Ser Gly Gly Gly Ser Pro Cys Glu Ala Gly Glu Glu Gly Glu 
    210                 215                 220                 


Gly Gly Val Cys Leu Asn Gly Gly Val Cys Ser Val Val Asp Asp Gln 
225                 230                 235                 240 


Ala Val Cys Asp Cys Ser Arg Thr Gly Phe Arg Gly Lys Asp Cys Ser 
                245                 250                 255     


Gln Gly Lys Glu Glu Tyr Ile Ala Thr Phe Lys Gly Ser Glu Tyr Phe 
            260                 265                 270         


Cys Tyr Asp Leu Ser Gln Asn Pro Ile Gln Ser Ser Ser Asp Glu Ile 
        275                 280                 285             


Thr Leu Ser Phe Lys Thr Leu Gln Arg Asn Gly Leu Met Leu His Thr 
    290                 295                 300                 


Gly Lys Ser Ala Asp Tyr Val Asn Leu Ala Leu Lys Asn Gly Ala Val 
305                 310                 315                 320 


Ser Leu Val Ile Asn Leu Gly Ser Gly Ala Phe Glu Ala Leu Val Glu 
                325                 330                 335     


Pro Val Asn Gly Lys Phe Asn Asp Asn Ala Trp His Asp Val Lys Val 
            340                 345                 350         


Thr Arg Asn Leu Arg Gln Val Thr Ile Ser Val Asp Gly Ile Leu Thr 
        355                 360                 365             


Thr Thr Gly Tyr Thr Gln Glu Asp Tyr Thr Met Leu Gly Ser Asp Asp 
    370                 375                 380                 


Phe Phe Tyr Val Gly Gly Ser Pro Ser Thr Ala Asp Leu Pro Gly Ser 
385                 390                 395                 400 


Pro Val Ser Asn Asn Phe Met Gly Cys Leu Lys Glu Val Asn Ile Val 
                405                 410                 415     


Ala Ile Arg Ile Ile Pro Asn Ser Trp Ser His His Phe Arg Ser Ser 
            420                 425                 430         


Met Lys Ala Pro Leu Leu Lys Thr Arg Cys Ser Arg Val Lys Arg His 
        435                 440                 445             


Asn Phe Lys Phe Asn Ile Leu Leu Leu Phe Met 
    450                 455                 


<210>  9566
<211>  277
<212>  PRT
<213>  Homo Sapiens

<400>  9566

Met Gly Thr Ala Leu Leu Gln Arg Gly Gly Cys Phe Leu Leu Cys Leu 
1               5                   10                  15      


Ser Leu Leu Leu Leu Gly Cys Trp Ala Glu Leu Gly Ser Gly Leu Glu 
            20                  25                  30          


Phe Pro Gly Ala Glu Gly Gln Trp Thr Arg Phe Pro Lys Trp Asn Ala 
        35                  40                  45              


Cys Cys Glu Ser Glu Met Ser Phe Gln Leu Lys Thr Arg Ser Ala Arg 
    50                  55                  60                  


Gly Leu Val Leu Tyr Phe Asp Asp Glu Gly Phe Cys Asp Phe Leu Glu 
65                  70                  75                  80  


Leu Ile Leu Thr Arg Gly Gly Arg Leu Gln Leu Ser Phe Ser Ile Phe 
                85                  90                  95      


Cys Ala Glu Pro Ala Thr Leu Leu Ala Asp Thr Pro Val Asn Asp Gly 
            100                 105                 110         


Ala Trp His Ser Val Arg Ile Arg Arg Gln Phe Arg Asn Thr Thr Leu 
        115                 120                 125             


Phe Ile Asp Gln Val Glu Ala Lys Trp Val Glu Val Lys Ser Lys Arg 
    130                 135                 140                 


Arg Asp Met Thr Val Phe Ser Gly Leu Phe Val Gly Gly Leu Pro Pro 
145                 150                 155                 160 


Glu Leu Arg Ala Ala Ala Leu Lys Leu Thr Leu Ala Ser Val Arg Glu 
                165                 170                 175     


Arg Glu Pro Phe Lys Gly Trp Ile Arg Asp Val Arg Val Asn Ser Ser 
            180                 185                 190         


Gln Val Leu Pro Val Asp Ser Gly Glu Val Lys Leu Asp Asp Glu Pro 
        195                 200                 205             


Pro Asn Ser Gly Gly Gly Ser Pro Cys Glu Ala Gly Glu Glu Gly Glu 
    210                 215                 220                 


Gly Gly Val Cys Leu Asn Gly Gly Val Cys Ser Val Val Asp Asp Gln 
225                 230                 235                 240 


Ala Val Cys Asp Cys Ser Arg Thr Gly Phe Arg Gly Lys Asp Cys Ser 
                245                 250                 255     


Gln Asp Asn Asn Val Glu Gly Leu Ala His Leu Met Met Gly Asp Gln 
            260                 265                 270         


Gly Lys Ser Lys Asp 
        275         


<210>  9567
<211>  293
<212>  PRT
<213>  Homo Sapiens

<400>  9567

Met Gly Thr Ala Leu Leu Gln Arg Gly Gly Cys Phe Leu Leu Cys Leu 
1               5                   10                  15      


Ser Leu Leu Leu Leu Gly Cys Trp Ala Glu Leu Gly Ser Gly Leu Glu 
            20                  25                  30          


Phe Pro Gly Ala Glu Gly Gln Trp Thr Arg Phe Pro Lys Trp Asn Ala 
        35                  40                  45              


Cys Cys Glu Ser Glu Met Ser Phe Gln Leu Lys Thr Arg Ser Ala Arg 
    50                  55                  60                  


Gly Leu Val Leu Tyr Phe Asp Asp Glu Gly Phe Cys Asp Phe Leu Glu 
65                  70                  75                  80  


Leu Ile Leu Thr Arg Gly Gly Arg Leu Gln Leu Ser Phe Ser Ile Phe 
                85                  90                  95      


Cys Ala Glu Pro Ala Thr Leu Leu Ala Asp Thr Pro Val Asn Asp Gly 
            100                 105                 110         


Ala Trp His Ser Val Arg Ile Arg Arg Gln Phe Arg Asn Thr Thr Leu 
        115                 120                 125             


Phe Ile Asp Gln Val Glu Ala Lys Trp Val Glu Val Lys Ser Lys Arg 
    130                 135                 140                 


Arg Asp Met Thr Val Phe Ser Gly Leu Phe Val Gly Gly Leu Pro Pro 
145                 150                 155                 160 


Glu Leu Arg Ala Ala Ala Leu Lys Leu Thr Leu Ala Ser Val Arg Glu 
                165                 170                 175     


Arg Glu Pro Phe Lys Gly Trp Ile Arg Asp Val Arg Val Asn Ser Ser 
            180                 185                 190         


Gln Val Leu Pro Val Asp Ser Gly Glu Val Lys Leu Asp Asp Glu Pro 
        195                 200                 205             


Pro Asn Ser Gly Gly Gly Ser Pro Cys Glu Ala Gly Glu Glu Gly Glu 
    210                 215                 220                 


Gly Gly Val Cys Leu Asn Gly Gly Val Cys Ser Val Val Asp Asp Gln 
225                 230                 235                 240 


Ala Val Cys Asp Cys Ser Arg Thr Gly Phe Arg Gly Lys Asp Cys Ser 
                245                 250                 255     


Gln Glu Asp Asn Asn Val Glu Gly Leu Ala His Leu Met Met Gly Asp 
            260                 265                 270         


Gln Gly Lys Ser Lys Glu Met Asn Asp Tyr Leu Asn Tyr Lys Lys Val 
        275                 280                 285             


Lys Ile Cys Tyr Thr 
    290             


<210>  9568
<211>  1499
<212>  PRT
<213>  Homo Sapiens

<400>  9568

Met Gly Thr Ala Leu Leu Gln Arg Gly Gly Cys Phe Leu Leu Cys Leu 
1               5                   10                  15      


Ser Leu Leu Leu Leu Gly Cys Trp Ala Glu Leu Gly Ser Gly Leu Glu 
            20                  25                  30          


Phe Pro Gly Ala Glu Gly Gln Trp Thr Arg Phe Pro Lys Trp Asn Ala 
        35                  40                  45              


Cys Cys Glu Ser Glu Met Ser Phe Gln Leu Lys Thr Arg Ser Ala Arg 
    50                  55                  60                  


Gly Leu Val Leu Tyr Phe Asp Asp Glu Gly Phe Cys Asp Phe Leu Glu 
65                  70                  75                  80  


Leu Ile Leu Thr Arg Gly Gly Arg Leu Gln Leu Ser Phe Ser Ile Phe 
                85                  90                  95      


Cys Ala Glu Pro Ala Thr Leu Leu Ala Asp Thr Pro Val Asn Asp Gly 
            100                 105                 110         


Ala Trp His Ser Val Arg Ile Arg Arg Gln Phe Arg Asn Thr Thr Leu 
        115                 120                 125             


Phe Ile Asp Gln Val Glu Ala Lys Trp Val Glu Val Lys Ser Lys Arg 
    130                 135                 140                 


Arg Asp Met Thr Val Phe Ser Gly Leu Phe Val Gly Gly Leu Pro Pro 
145                 150                 155                 160 


Glu Leu Arg Ala Ala Ala Leu Lys Leu Thr Leu Ala Ser Val Arg Glu 
                165                 170                 175     


Arg Glu Pro Phe Lys Gly Trp Ile Arg Asp Val Arg Val Asn Ser Ser 
            180                 185                 190         


Gln Val Leu Pro Val Asp Ser Gly Glu Val Lys Leu Asp Asp Glu Pro 
        195                 200                 205             


Pro Asn Ser Gly Gly Gly Ser Pro Cys Glu Ala Gly Glu Glu Gly Glu 
    210                 215                 220                 


Gly Gly Val Cys Leu Asn Gly Gly Val Cys Ser Val Val Asp Asp Gln 
225                 230                 235                 240 


Ala Val Cys Asp Cys Ser Arg Thr Gly Phe Arg Gly Lys Asp Cys Ser 
                245                 250                 255     


Gln Glu Asp Asn Asn Val Glu Gly Leu Ala His Leu Met Met Gly Asp 
            260                 265                 270         


Gln Gly Lys Ser Lys Gly Lys Glu Glu Tyr Ile Ala Thr Phe Lys Gly 
        275                 280                 285             


Ser Glu Tyr Phe Cys Tyr Asp Leu Ser Gln Asn Pro Ile Gln Ser Ser 
    290                 295                 300                 


Ser Asp Glu Ile Thr Leu Ser Phe Lys Thr Leu Gln Arg Asn Gly Leu 
305                 310                 315                 320 


Met Leu His Thr Gly Lys Ser Ala Asp Tyr Val Asn Leu Ala Leu Lys 
                325                 330                 335     


Asn Gly Ala Val Ser Leu Val Ile Asn Leu Gly Ser Gly Ala Phe Glu 
            340                 345                 350         


Ala Leu Val Glu Pro Val Asn Gly Lys Phe Asn Asp Asn Ala Trp His 
        355                 360                 365             


Asp Val Lys Val Thr Arg Asn Leu Arg Gln Val Thr Ile Ser Val Asp 
    370                 375                 380                 


Gly Ile Leu Thr Thr Thr Gly Tyr Thr Gln Glu Asp Tyr Thr Met Leu 
385                 390                 395                 400 


Gly Ser Asp Asp Phe Phe Tyr Val Gly Gly Ser Pro Ser Thr Ala Asp 
                405                 410                 415     


Leu Pro Gly Ser Pro Val Ser Asn Asn Phe Met Gly Cys Leu Lys Glu 
            420                 425                 430         


Val Val Tyr Lys Asn Asn Asp Val Arg Leu Glu Leu Ser Arg Leu Ala 
        435                 440                 445             


Lys Gln Gly Asp Pro Lys Met Lys Ile His Gly Val Val Ala Phe Lys 
    450                 455                 460                 


Cys Glu Asn Val Ala Thr Leu Asp Pro Ile Thr Phe Glu Thr Pro Glu 
465                 470                 475                 480 


Ser Phe Ile Ser Leu Pro Lys Trp Asn Ala Lys Lys Thr Gly Ser Ile 
                485                 490                 495     


Ser Phe Asp Phe Arg Thr Thr Glu Pro Asn Gly Leu Ile Leu Phe Ser 
            500                 505                 510         


His Gly Lys Pro Arg His Gln Lys Asp Ala Lys His Pro Gln Met Ile 
        515                 520                 525             


Lys Val Asp Phe Phe Ala Ile Glu Met Leu Asp Gly His Leu Tyr Leu 
    530                 535                 540                 


Leu Leu Asp Met Gly Ser Gly Thr Ile Lys Ile Lys Ala Leu Leu Lys 
545                 550                 555                 560 


Lys Val Asn Asp Gly Glu Trp Tyr His Val Asp Phe Gln Arg Asp Gly 
                565                 570                 575     


Arg Ser Gly Thr Ile Ser Val Asn Thr Leu Arg Thr Pro Tyr Thr Ala 
            580                 585                 590         


Pro Gly Glu Ser Glu Ile Leu Asp Leu Asp Asp Glu Leu Tyr Leu Gly 
        595                 600                 605             


Gly Leu Pro Glu Asn Lys Ala Gly Leu Val Phe Pro Thr Glu Val Trp 
    610                 615                 620                 


Thr Ala Leu Leu Asn Tyr Gly Tyr Val Gly Cys Ile Arg Asp Leu Phe 
625                 630                 635                 640 


Ile Asp Gly Gln Ser Lys Asp Ile Arg Gln Met Ala Glu Val Gln Ser 
                645                 650                 655     


Thr Ala Gly Val Lys Pro Ser Cys Ser Lys Glu Thr Ala Lys Pro Cys 
            660                 665                 670         


Leu Ser Asn Pro Cys Lys Asn Asn Gly Met Cys Arg Asp Gly Trp Asn 
        675                 680                 685             


Arg Tyr Val Cys Asp Cys Ser Gly Thr Gly Tyr Leu Gly Arg Ser Cys 
    690                 695                 700                 


Glu Arg Glu Ala Thr Val Leu Ser Tyr Asp Gly Ser Met Phe Met Lys 
705                 710                 715                 720 


Ile Gln Leu Pro Val Val Met His Thr Glu Ala Glu Asp Val Ser Leu 
                725                 730                 735     


Arg Phe Arg Ser Gln Arg Ala Tyr Gly Ile Leu Met Ala Thr Thr Ser 
            740                 745                 750         


Arg Asp Ser Ala Asp Thr Leu Arg Leu Glu Leu Asp Ala Gly Arg Val 
        755                 760                 765             


Lys Leu Thr Val Asn Leu Asp Cys Ile Arg Ile Asn Cys Asn Ser Ser 
    770                 775                 780                 


Lys Gly Pro Glu Thr Leu Phe Ala Gly Tyr Asn Leu Asn Asp Asn Glu 
785                 790                 795                 800 


Trp His Thr Val Arg Val Val Arg Arg Gly Lys Ser Leu Lys Leu Thr 
                805                 810                 815     


Val Asp Asp Gln Gln Ala Met Thr Gly Gln Met Ala Gly Asp His Thr 
            820                 825                 830         


Arg Leu Glu Phe His Asn Ile Glu Thr Gly Ile Ile Thr Glu Arg Arg 
        835                 840                 845             


Tyr Leu Ser Ser Val Pro Ser Asn Phe Ile Gly His Leu Gln Ser Leu 
    850                 855                 860                 


Thr Phe Asn Gly Met Ala Tyr Ile Asp Leu Cys Lys Asn Gly Asp Ile 
865                 870                 875                 880 


Asp Tyr Cys Glu Leu Asn Ala Arg Phe Gly Phe Arg Asn Ile Ile Ala 
                885                 890                 895     


Asp Pro Val Thr Phe Lys Thr Lys Ser Ser Tyr Val Ala Leu Ala Thr 
            900                 905                 910         


Leu Gln Ala Tyr Thr Ser Met His Leu Phe Phe Gln Phe Lys Thr Thr 
        915                 920                 925             


Ser Leu Asp Gly Leu Ile Leu Tyr Asn Ser Gly Asp Gly Asn Asp Phe 
    930                 935                 940                 


Ile Val Val Glu Leu Val Lys Gly Tyr Leu His Tyr Val Phe Asp Leu 
945                 950                 955                 960 


Gly Asn Gly Ala Asn Leu Ile Lys Gly Ser Ser Asn Lys Pro Leu Asn 
                965                 970                 975     


Asp Asn Gln Trp His Asn Val Met Ile Ser Arg Asp Thr Ser Asn Leu 
            980                 985                 990         


His Thr Val Lys Ile Asp Thr Lys  Ile Thr Thr Gln Ile  Thr Ala Gly 
        995                 1000                 1005             


Ala Arg  Asn Leu Asp Leu Lys  Ser Asp Leu Tyr Ile  Gly Gly Val 
    1010                 1015                 1020             


Ala Lys  Glu Thr Tyr Lys Ser  Leu Pro Lys Leu Val  His Ala Lys 
    1025                 1030                 1035             


Glu Gly  Phe Gln Gly Cys Leu  Ala Ser Val Asp Leu  Asn Gly Arg 
    1040                 1045                 1050             


Leu Pro  Asp Leu Ile Ser Asp  Ala Leu Phe Cys Asn  Gly Gln Ile 
    1055                 1060                 1065             


Glu Arg  Gly Cys Glu Gly Pro  Ser Thr Thr Cys Gln  Glu Asp Ser 
    1070                 1075                 1080             


Cys Ser  Asn Gln Gly Val Cys  Leu Gln Gln Trp Asp  Gly Phe Ser 
    1085                 1090                 1095             


Cys Asp  Cys Ser Met Thr Ser  Phe Ser Gly Pro Leu  Cys Asn Asp 
    1100                 1105                 1110             


Pro Gly  Thr Thr Tyr Ile Phe  Ser Lys Gly Gly Gly  Gln Ile Thr 
    1115                 1120                 1125             


Tyr Lys  Trp Pro Pro Asn Asp  Arg Pro Ser Thr Arg  Ala Asp Arg 
    1130                 1135                 1140             


Leu Ala  Ile Gly Phe Ser Thr  Val Gln Lys Glu Ala  Val Leu Val 
    1145                 1150                 1155             


Arg Val  Asp Ser Ser Ser Gly  Leu Gly Asp Tyr Leu  Glu Leu His 
    1160                 1165                 1170             


Ile His  Gln Gly Lys Ile Gly  Val Lys Phe Asn Val  Gly Thr Asp 
    1175                 1180                 1185             


Asp Ile  Ala Ile Glu Glu Ser  Asn Ala Ile Ile Asn  Asp Gly Lys 
    1190                 1195                 1200             


Tyr His  Val Val Arg Phe Thr  Arg Ser Gly Gly Asn  Ala Thr Leu 
    1205                 1210                 1215             


Gln Val  Asp Ser Trp Pro Val  Ile Glu Arg Tyr Pro  Ala Gly Asn 
    1220                 1225                 1230             


Asn Asp  Asn Glu Arg Leu Ala  Ile Ala Arg Gln Arg  Ile Pro Tyr 
    1235                 1240                 1245             


Arg Leu  Gly Arg Val Val Asp  Glu Trp Leu Leu Asp  Lys Gly Arg 
    1250                 1255                 1260             


Gln Leu  Thr Ile Phe Asn Ser  Gln Ala Thr Ile Ile  Ile Gly Gly 
    1265                 1270                 1275             


Lys Glu  Gln Gly Gln Pro Phe  Gln Gly Gln Leu Ser  Gly Leu Tyr 
    1280                 1285                 1290             


Tyr Asn  Gly Leu Lys Val Leu  Asn Met Ala Ala Glu  Asn Asp Ala 
    1295                 1300                 1305             


Asn Ile  Ala Ile Val Gly Asn  Val Arg Leu Val Gly  Glu Val Pro 
    1310                 1315                 1320             


Ser Ser  Met Thr Thr Glu Ser  Thr Ala Thr Ala Met  Gln Ser Glu 
    1325                 1330                 1335             


Met Ser  Thr Ser Ile Met Glu  Thr Thr Thr Thr Leu  Ala Thr Ser 
    1340                 1345                 1350             


Thr Ala  Arg Arg Gly Lys Pro  Pro Thr Lys Glu Pro  Ile Ser Gln 
    1355                 1360                 1365             


Thr Thr  Asp Asp Ile Leu Val  Ala Ser Ala Glu Cys  Pro Ser Asp 
    1370                 1375                 1380             


Asp Glu  Asp Ile Asp Pro Cys  Glu Pro Ser Ser Gly  Gly Leu Ala 
    1385                 1390                 1395             


Asn Pro  Thr Arg Ala Gly Gly  Arg Glu Pro Tyr Pro  Gly Ser Ala 
    1400                 1405                 1410             


Glu Val  Ile Arg Glu Ser Ser  Ser Thr Thr Gly Met  Val Val Gly 
    1415                 1420                 1425             


Ile Val  Ala Ala Ala Ala Leu  Cys Ile Leu Ile Leu  Leu Tyr Ala 
    1430                 1435                 1440             


Met Tyr  Lys Tyr Arg Asn Arg  Asp Glu Gly Ser Tyr  His Val Asp 
    1445                 1450                 1455             


Glu Ser  Arg Asn Tyr Ile Ser  Asn Ser Ala Gln Ser  Asn Gly Ala 
    1460                 1465                 1470             


Val Val  Lys Glu Lys Gln Pro  Ser Ser Ala Lys Ser  Ser Asn Lys 
    1475                 1480                 1485             


Asn Lys  Lys Asn Lys Asp Lys  Glu Tyr Tyr Val 
    1490                 1495                 


<210>  9569
<211>  56
<212>  PRT
<213>  Homo Sapiens

<400>  9569

Met Thr Ser Gly Ser Lys Cys Pro Ser Thr Asp Ser Ala Ser Leu Leu 
1               5                   10                  15      


Pro Arg Lys Ser Arg Gly Leu Met Ala Tyr Ile Leu Pro Leu Val Gln 
            20                  25                  30          


Leu Thr Ser Ser Val Gly Glu Asp Cys Ser Phe Gln Ile Ser Thr Phe 
        35                  40                  45              


Leu Phe Asp Leu Ser Ser Ile Ser 
    50                  55      


<210>  9570
<211>  176
<212>  PRT
<213>  Homo Sapiens

<400>  9570

Met Thr Ser Gly Ser Lys Cys Pro Ser Thr Asp Ser Gly Lys Glu Glu 
1               5                   10                  15      


Tyr Ile Ala Thr Phe Lys Gly Ser Glu Tyr Phe Cys Tyr Asp Leu Ser 
            20                  25                  30          


Gln Asn Pro Ile Gln Ser Ser Ser Asp Glu Ile Thr Leu Ser Phe Lys 
        35                  40                  45              


Thr Leu Gln Arg Asn Gly Leu Met Leu His Thr Gly Lys Ser Ala Asp 
    50                  55                  60                  


Tyr Val Asn Leu Ala Leu Lys Asn Gly Ala Val Ser Leu Val Ile Asn 
65                  70                  75                  80  


Leu Gly Ser Gly Ala Phe Glu Ala Leu Val Glu Pro Val Asn Gly Lys 
                85                  90                  95      


Phe Asn Asp Asn Ala Trp His Asp Val Lys Val Thr Arg Asn Leu Arg 
            100                 105                 110         


Gln Val Thr Ile Ser Val Asp Gly Ile Leu Thr Thr Thr Gly Tyr Thr 
        115                 120                 125             


Gln Glu Asp Tyr Thr Met Leu Gly Ser Asp Asp Phe Phe Tyr Val Gly 
    130                 135                 140                 


Gly Ser Pro Ser Thr Ala Asp Leu Pro Gly Ser Pro Ile Gln His Glu 
145                 150                 155                 160 


Ser Thr Phe Ala Glu Asp Pro Met Phe Gln Ser Gln Thr Ala Gln Leu 
                165                 170                 175     


<210>  9571
<211>  903
<212>  PRT
<213>  Homo Sapiens

<400>  9571

Met Thr Ser Gly Ser Lys Cys Pro Ser Thr Asp Ser Gly Lys Glu Glu 
1               5                   10                  15      


Tyr Ile Ala Thr Phe Lys Gly Ser Glu Tyr Phe Cys Tyr Asp Leu Ser 
            20                  25                  30          


Gln Asn Pro Ile Gln Ser Ser Ser Asp Glu Ile Thr Leu Ser Phe Lys 
        35                  40                  45              


Thr Leu Gln Arg Asn Gly Leu Met Leu His Thr Gly Lys Ser Ala Asp 
    50                  55                  60                  


Tyr Val Asn Leu Ala Leu Lys Asn Gly Ala Val Ser Leu Val Ile Asn 
65                  70                  75                  80  


Leu Gly Ser Gly Ala Phe Glu Ala Leu Val Glu Pro Val Asn Gly Lys 
                85                  90                  95      


Phe Asn Asp Asn Ala Trp His Asp Val Lys Val Thr Arg Asn Leu Arg 
            100                 105                 110         


Gln Val Thr Ile Ser Val Asp Gly Ile Leu Thr Thr Thr Gly Tyr Thr 
        115                 120                 125             


Gln Glu Asp Tyr Thr Met Leu Gly Ser Asp Asp Phe Phe Tyr Val Gly 
    130                 135                 140                 


Gly Ser Pro Ser Thr Ala Asp Leu Pro Gly Ser Pro Val Ser Asn Asn 
145                 150                 155                 160 


Phe Met Gly Cys Leu Lys Glu Val Val Tyr Lys Asn Asn Asp Val Arg 
                165                 170                 175     


Leu Glu Leu Ser Arg Leu Ala Lys Gln Gly Asp Pro Lys Met Lys Ile 
            180                 185                 190         


His Gly Val Val Ala Phe Lys Cys Glu Asn Val Ala Thr Leu Asp Pro 
        195                 200                 205             


Ile Thr Phe Glu Thr Pro Glu Ser Phe Ile Ser Leu Pro Lys Trp Asn 
    210                 215                 220                 


Ala Lys Lys Thr Gly Ser Ile Ser Phe Asp Phe Arg Thr Thr Glu Pro 
225                 230                 235                 240 


Asn Gly Leu Ile Leu Phe Ser His Gly Lys Pro Arg His Gln Lys Asp 
                245                 250                 255     


Ala Lys His Pro Gln Met Ile Lys Val Asp Phe Phe Ala Ile Glu Met 
            260                 265                 270         


Leu Asp Gly His Leu Tyr Leu Leu Leu Asp Met Gly Ser Gly Thr Ile 
        275                 280                 285             


Lys Ile Lys Ala Leu Leu Lys Lys Val Asn Asp Gly Glu Trp Tyr His 
    290                 295                 300                 


Val Asp Phe Gln Arg Asp Gly Arg Ser Gly Thr Ile Ser Val Asn Thr 
305                 310                 315                 320 


Leu Arg Thr Pro Tyr Thr Ala Pro Gly Glu Ser Glu Ile Leu Asp Leu 
                325                 330                 335     


Asp Asp Glu Leu Tyr Leu Gly Gly Leu Pro Glu Asn Lys Ala Gly Leu 
            340                 345                 350         


Val Phe Pro Thr Glu Val Trp Thr Ala Leu Leu Asn Tyr Gly Tyr Val 
        355                 360                 365             


Gly Cys Ile Arg Asp Leu Phe Ile Asp Gly Gln Ser Lys Asp Ile Arg 
    370                 375                 380                 


Gln Met Ala Glu Val Gln Ser Thr Ala Gly Val Lys Pro Ser Cys Ser 
385                 390                 395                 400 


Lys Glu Thr Ala Lys Pro Cys Leu Ser Asn Pro Cys Lys Asn Asn Gly 
                405                 410                 415     


Met Cys Arg Asp Gly Trp Asn Arg Tyr Val Cys Asp Cys Ser Gly Thr 
            420                 425                 430         


Gly Tyr Leu Gly Arg Ser Cys Glu Arg Glu Ala Thr Val Leu Ser Tyr 
        435                 440                 445             


Asp Gly Ser Met Phe Met Lys Ile Gln Leu Pro Val Val Met His Thr 
    450                 455                 460                 


Glu Ala Glu Asp Val Ser Leu Arg Phe Arg Ser Gln Arg Ala Tyr Gly 
465                 470                 475                 480 


Ile Leu Met Ala Thr Thr Ser Arg Asp Ser Ala Asp Thr Leu Arg Leu 
                485                 490                 495     


Glu Leu Asp Ala Gly Arg Val Lys Leu Thr Val Asn Leu Gly Lys Gly 
            500                 505                 510         


Pro Glu Thr Leu Phe Ala Gly Tyr Asn Leu Asn Asp Asn Glu Trp His 
        515                 520                 525             


Thr Val Arg Val Val Arg Arg Gly Lys Ser Leu Lys Leu Thr Val Asp 
    530                 535                 540                 


Asp Gln Gln Ala Met Thr Gly Gln Met Ala Gly Asp His Thr Arg Leu 
545                 550                 555                 560 


Glu Phe His Asn Ile Glu Thr Gly Ile Ile Thr Glu Arg Arg Tyr Leu 
                565                 570                 575     


Ser Ser Val Pro Ser Asn Phe Ile Gly His Leu Gln Ser Leu Thr Phe 
            580                 585                 590         


Asn Gly Met Ala Tyr Ile Asp Leu Cys Lys Asn Gly Asp Ile Asp Tyr 
        595                 600                 605             


Cys Glu Leu Asn Ala Arg Phe Gly Phe Arg Asn Ile Ile Ala Asp Pro 
    610                 615                 620                 


Val Thr Phe Lys Thr Lys Ser Ser Tyr Val Ala Leu Ala Thr Leu Gln 
625                 630                 635                 640 


Ala Tyr Thr Ser Met His Leu Phe Phe Gln Phe Lys Thr Thr Ser Leu 
                645                 650                 655     


Asp Gly Leu Ile Leu Tyr Asn Ser Gly Asp Gly Asn Asp Phe Ile Val 
            660                 665                 670         


Val Glu Leu Val Lys Gly Tyr Leu His Tyr Val Phe Asp Leu Gly Asn 
        675                 680                 685             


Gly Ala Asn Leu Ile Lys Gly Ser Ser Asn Lys Pro Leu Asn Asp Asn 
    690                 695                 700                 


Gln Trp His Asn Val Met Ile Ser Arg Asp Thr Ser Asn Leu His Thr 
705                 710                 715                 720 


Val Lys Ile Asp Thr Lys Ile Thr Thr Gln Ile Thr Ala Gly Ala Arg 
                725                 730                 735     


Asn Leu Asp Leu Lys Ser Asp Leu Tyr Ile Gly Gly Val Ala Lys Glu 
            740                 745                 750         


Thr Tyr Lys Ser Leu Pro Lys Leu Val His Ala Lys Glu Gly Phe Gln 
        755                 760                 765             


Gly Cys Leu Ala Ser Val Asp Leu Asn Gly Arg Leu Pro Asp Leu Ile 
    770                 775                 780                 


Ser Asp Ala Leu Phe Cys Asn Gly Gln Ile Glu Arg Gly Cys Glu Gly 
785                 790                 795                 800 


Pro Ser Thr Thr Cys Gln Glu Asp Ser Cys Ser Asn Gln Gly Val Cys 
                805                 810                 815     


Leu Gln Gln Trp Asp Gly Phe Ser Cys Asp Cys Ser Met Thr Ser Phe 
            820                 825                 830         


Ser Gly Pro Leu Cys Asn Asp Pro Gly Thr Thr Tyr Ile Phe Ser Lys 
        835                 840                 845             


Gly Gly Gly Gln Ile Thr Tyr Lys Trp Pro Pro Asn Asp Arg Pro Ser 
    850                 855                 860                 


Thr Arg Ala Asp Arg Leu Ala Ile Gly Phe Ser Thr Val Gln Lys Glu 
865                 870                 875                 880 


Ala Val Leu Val Arg Val Asp Ser Ser Ser Gly Leu Gly Asp Tyr Leu 
                885                 890                 895     


Glu Leu His Ile Thr Leu Gln 
            900             


<210>  9572
<211>  75
<212>  PRT
<213>  Homo Sapiens

<400>  9572

Met Val Val Gly Ile Val Ala Ala Ala Ala Leu Cys Ile Leu Ile Leu 
1               5                   10                  15      


Leu Tyr Ala Met Tyr Lys Tyr Arg Asn Arg Asp Glu Gly Ser Tyr His 
            20                  25                  30          


Val Asp Glu Ser Arg Asn Tyr Ile Ser Asn Ser Ala Gln Ser Asn Gly 
        35                  40                  45              


Ala Val Val Lys Glu Lys Gln Pro Ser Ser Ala Lys Ser Ser Asn Lys 
    50                  55                  60                  


Asn Lys Lys Asn Lys Asp Lys Glu Tyr Tyr Val 
65                  70                  75  


<210>  9573
<211>  472
<212>  PRT
<213>  Homo Sapiens

<400>  9573

Met Tyr Gln Arg Met Leu Arg Cys Gly Ala Glu Leu Gly Ser Pro Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Gly Gly Arg Leu Ala 
            20                  25                  30          


Leu Leu Trp Ile Val Pro Leu Thr Leu Ser Gly Leu Leu Gly Val Ala 
        35                  40                  45              


Trp Gly Ala Ser Ser Leu Gly Ala His His Ile His His Phe His Gly 
    50                  55                  60                  


Ser Ser Lys His His Ser Val Pro Ile Ala Ile Tyr Arg Ser Pro Ala 
65                  70                  75                  80  


Ser Leu Arg Gly Gly His Ala Gly Thr Thr Tyr Ile Phe Ser Lys Gly 
                85                  90                  95      


Gly Gly Gln Ile Thr Tyr Lys Trp Pro Pro Asn Asp Arg Pro Ser Thr 
            100                 105                 110         


Arg Ala Asp Arg Leu Ala Ile Gly Phe Ser Thr Val Gln Lys Glu Ala 
        115                 120                 125             


Val Leu Val Arg Val Asp Ser Ser Ser Gly Leu Gly Asp Tyr Leu Glu 
    130                 135                 140                 


Leu His Ile His Gln Gly Lys Ile Gly Val Lys Phe Asn Val Gly Thr 
145                 150                 155                 160 


Asp Asp Ile Ala Ile Glu Glu Ser Asn Ala Ile Ile Asn Asp Gly Lys 
                165                 170                 175     


Tyr His Val Val Arg Phe Thr Arg Ser Gly Gly Asn Ala Thr Leu Gln 
            180                 185                 190         


Val Asp Ser Trp Pro Val Ile Glu Arg Tyr Pro Ala Gly Asn Asn Asp 
        195                 200                 205             


Asn Glu Arg Leu Ala Ile Ala Arg Gln Arg Ile Pro Tyr Arg Leu Gly 
    210                 215                 220                 


Arg Val Val Asp Glu Trp Leu Leu Asp Lys Gly Arg Gln Leu Thr Ile 
225                 230                 235                 240 


Phe Asn Ser Gln Ala Thr Ile Ile Ile Gly Gly Lys Glu Gln Gly Gln 
                245                 250                 255     


Pro Phe Gln Gly Gln Leu Ser Gly Leu Tyr Tyr Asn Gly Leu Lys Val 
            260                 265                 270         


Leu Asn Met Ala Ala Glu Asn Asp Ala Asn Ile Ala Ile Val Gly Asn 
        275                 280                 285             


Val Arg Leu Val Gly Glu Val Pro Ser Ser Met Thr Thr Glu Ser Thr 
    290                 295                 300                 


Ala Thr Ala Met Gln Ser Glu Met Ser Thr Ser Ile Met Glu Thr Thr 
305                 310                 315                 320 


Thr Thr Leu Ala Thr Ser Thr Ala Arg Arg Gly Lys Pro Pro Thr Lys 
                325                 330                 335     


Glu Pro Ile Ser Gln Thr Thr Asp Asp Ile Leu Val Ala Ser Ala Glu 
            340                 345                 350         


Cys Pro Ser Asp Asp Glu Asp Ile Asp Pro Cys Glu Pro Ser Ser Gly 
        355                 360                 365             


Gly Leu Ala Asn Pro Thr Arg Ala Gly Gly Arg Glu Pro Tyr Pro Gly 
    370                 375                 380                 


Ser Ala Glu Val Ile Arg Glu Ser Ser Ser Thr Thr Gly Met Val Val 
385                 390                 395                 400 


Gly Ile Val Ala Ala Ala Ala Leu Cys Ile Leu Ile Leu Leu Tyr Ala 
                405                 410                 415     


Met Tyr Lys Tyr Arg Asn Arg Asp Glu Gly Ser Tyr His Val Asp Glu 
            420                 425                 430         


Ser Arg Asn Tyr Ile Ser Asn Ser Ala Gln Ser Asn Gly Ala Val Val 
        435                 440                 445             


Lys Glu Lys Gln Pro Ser Ser Ala Lys Ser Ser Asn Lys Asn Lys Lys 
    450                 455                 460                 


Asn Lys Asp Lys Glu Tyr Tyr Val 
465                 470         


<210>  9574
<211>  469
<212>  PRT
<213>  Homo Sapiens

<400>  9574

Met Tyr Gln Arg Met Leu Arg Cys Gly Ala Glu Leu Gly Ser Pro Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Gly Gly Arg Leu Ala 
            20                  25                  30          


Leu Leu Trp Ile Val Pro Leu Thr Leu Ser Gly Leu Leu Gly Val Ala 
        35                  40                  45              


Trp Gly Ala Ser Ser Leu Gly Ala His His Ile His His Phe His Gly 
    50                  55                  60                  


Ser Ser Lys His His Ser Val Pro Ile Ala Ile Tyr Arg Ser Pro Ala 
65                  70                  75                  80  


Ser Leu Arg Gly Gly His Ala Gly Thr Thr Tyr Ile Phe Ser Lys Gly 
                85                  90                  95      


Gly Gly Gln Ile Thr Tyr Lys Trp Pro Pro Asn Asp Arg Pro Ser Thr 
            100                 105                 110         


Arg Ala Asp Arg Leu Ala Ile Gly Phe Ser Thr Val Gln Lys Glu Ala 
        115                 120                 125             


Val Leu Val Arg Val Asp Ser Ser Ser Gly Leu Gly Asp Tyr Leu Glu 
    130                 135                 140                 


Leu His Ile His Gln Gly Lys Ile Gly Val Lys Phe Asn Val Gly Thr 
145                 150                 155                 160 


Asp Asp Ile Ala Ile Glu Glu Ser Asn Ala Ile Ile Asn Asp Gly Lys 
                165                 170                 175     


Tyr His Val Val Arg Phe Thr Arg Ser Gly Gly Asn Ala Thr Leu Gln 
            180                 185                 190         


Val Asp Ser Trp Pro Val Ile Glu Arg Tyr Pro Ala Gly Asn Asn Asp 
        195                 200                 205             


Asn Glu Arg Leu Ala Ile Ala Arg Gln Arg Ile Pro Tyr Arg Leu Gly 
    210                 215                 220                 


Arg Val Val Asp Glu Trp Leu Leu Asp Lys Gly Arg Gln Leu Thr Ile 
225                 230                 235                 240 


Phe Asn Ser Gln Ala Thr Ile Ile Ile Gly Gly Lys Glu Gln Gly Gln 
                245                 250                 255     


Pro Phe Gln Gly Gln Leu Ser Gly Leu Tyr Tyr Asn Gly Leu Lys Val 
            260                 265                 270         


Leu Asn Met Ala Ala Glu Asn Asp Ala Asn Ile Ala Ile Val Gly Asn 
        275                 280                 285             


Val Arg Leu Val Gly Glu Val Pro Ser Ser Met Thr Thr Glu Ser Thr 
    290                 295                 300                 


Ala Thr Ala Met Gln Ser Glu Met Ser Thr Ser Ile Met Glu Thr Thr 
305                 310                 315                 320 


Thr Thr Leu Ala Thr Ser Thr Ala Arg Arg Gly Lys Pro Pro Thr Lys 
                325                 330                 335     


Glu Pro Ile Ser Gln Thr Thr Asp Asp Ile Leu Val Ala Ser Ala Glu 
            340                 345                 350         


Cys Pro Ser Asp Asp Glu Asp Ile Asp Pro Cys Glu Pro Ser Ser Ala 
        355                 360                 365             


Asn Pro Thr Arg Ala Gly Gly Arg Glu Pro Tyr Pro Gly Ser Ala Glu 
    370                 375                 380                 


Val Ile Arg Glu Ser Ser Ser Thr Thr Gly Met Val Val Gly Ile Val 
385                 390                 395                 400 


Ala Ala Ala Ala Leu Cys Ile Leu Ile Leu Leu Tyr Ala Met Tyr Lys 
                405                 410                 415     


Tyr Arg Asn Arg Asp Glu Gly Ser Tyr His Val Asp Glu Ser Arg Asn 
            420                 425                 430         


Tyr Ile Ser Asn Ser Ala Gln Ser Asn Gly Ala Val Val Lys Glu Lys 
        435                 440                 445             


Gln Pro Ser Ser Ala Lys Ser Ser Asn Lys Asn Lys Lys Asn Lys Asp 
    450                 455                 460                 


Lys Glu Tyr Tyr Val 
465                 


<210>  9575
<211>  442
<212>  PRT
<213>  Homo Sapiens

<400>  9575

Met Tyr Gln Arg Met Leu Arg Cys Gly Ala Glu Leu Gly Ser Pro Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Gly Gly Arg Leu Ala 
            20                  25                  30          


Leu Leu Trp Ile Val Pro Leu Thr Leu Ser Gly Leu Leu Gly Val Ala 
        35                  40                  45              


Trp Gly Ala Ser Ser Leu Gly Ala His His Ile His His Phe His Gly 
    50                  55                  60                  


Ser Ser Lys His His Ser Val Pro Ile Ala Ile Tyr Arg Ser Pro Ala 
65                  70                  75                  80  


Ser Leu Arg Gly Gly His Ala Gly Thr Thr Tyr Ile Phe Ser Lys Gly 
                85                  90                  95      


Gly Gly Gln Ile Thr Tyr Lys Trp Pro Pro Asn Asp Arg Pro Ser Thr 
            100                 105                 110         


Arg Ala Asp Arg Leu Ala Ile Gly Phe Ser Thr Val Gln Lys Glu Ala 
        115                 120                 125             


Val Leu Val Arg Val Asp Ser Ser Ser Gly Leu Gly Asp Tyr Leu Glu 
    130                 135                 140                 


Leu His Ile His Gln Gly Lys Ile Gly Val Lys Phe Asn Val Gly Thr 
145                 150                 155                 160 


Asp Asp Ile Ala Ile Glu Glu Ser Asn Ala Ile Ile Asn Asp Gly Lys 
                165                 170                 175     


Tyr His Val Val Arg Phe Thr Arg Ser Gly Gly Asn Ala Thr Leu Gln 
            180                 185                 190         


Val Asp Ser Trp Pro Val Ile Glu Arg Tyr Pro Ala Gly Arg Gln Leu 
        195                 200                 205             


Thr Ile Phe Asn Ser Gln Ala Thr Ile Ile Ile Gly Gly Lys Glu Gln 
    210                 215                 220                 


Gly Gln Pro Phe Gln Gly Gln Leu Ser Gly Leu Tyr Tyr Asn Gly Leu 
225                 230                 235                 240 


Lys Val Leu Asn Met Ala Ala Glu Asn Asp Ala Asn Ile Ala Ile Val 
                245                 250                 255     


Gly Asn Val Arg Leu Val Gly Glu Val Pro Ser Ser Met Thr Thr Glu 
            260                 265                 270         


Ser Thr Ala Thr Ala Met Gln Ser Glu Met Ser Thr Ser Ile Met Glu 
        275                 280                 285             


Thr Thr Thr Thr Leu Ala Thr Ser Thr Ala Arg Arg Gly Lys Pro Pro 
    290                 295                 300                 


Thr Lys Glu Pro Ile Ser Gln Thr Thr Asp Asp Ile Leu Val Ala Ser 
305                 310                 315                 320 


Ala Glu Cys Pro Ser Asp Asp Glu Asp Ile Asp Pro Cys Glu Pro Ser 
                325                 330                 335     


Ser Gly Gly Leu Ala Asn Pro Thr Arg Ala Gly Gly Arg Glu Pro Tyr 
            340                 345                 350         


Pro Gly Ser Ala Glu Val Ile Arg Glu Ser Ser Ser Thr Thr Gly Met 
        355                 360                 365             


Val Val Gly Ile Val Ala Ala Ala Ala Leu Cys Ile Leu Ile Leu Leu 
    370                 375                 380                 


Tyr Ala Met Tyr Lys Tyr Arg Asn Arg Asp Glu Gly Ser Tyr His Val 
385                 390                 395                 400 


Asp Glu Ser Arg Asn Tyr Ile Ser Asn Ser Ala Gln Ser Asn Gly Ala 
                405                 410                 415     


Val Val Lys Glu Lys Gln Pro Ser Ser Ala Lys Ser Ser Asn Lys Asn 
            420                 425                 430         


Lys Lys Asn Lys Asp Lys Glu Tyr Tyr Val 
        435                 440         


<210>  9576
<211>  136
<212>  PRT
<213>  Homo Sapiens

<400>  9576

Ser Ser Gln Val Leu Pro Val Asp Ser Gly Glu Val Lys Leu Asp Asp 
1               5                   10                  15      


Glu Pro Pro Asn Ser Gly Gly Gly Ser Pro Cys Glu Ala Gly Glu Glu 
            20                  25                  30          


Gly Glu Gly Gly Val Cys Leu Asn Gly Gly Val Cys Ser Val Val Asp 
        35                  40                  45              


Asp Gln Ala Val Cys Asp Cys Ser Arg Thr Gly Phe Arg Gly Lys Asp 
    50                  55                  60                  


Cys Ser Gln Glu Ile Lys Phe Gly Leu Gln Cys Val Leu Pro Val Leu 
65                  70                  75                  80  


Leu His Asp Asn Asp Gln Gly Lys Tyr Cys Cys Ile Asn Thr Ala Lys 
                85                  90                  95      


Pro Leu Thr Glu Lys Asp Asn Asn Val Glu Gly Leu Ala His Leu Met 
            100                 105                 110         


Met Gly Asp Gln Gly Lys Ser Lys Glu Lys Leu Glu Ile Phe Arg Trp 
        115                 120                 125             


Ile Arg Lys Asp Phe Thr Asn Phe 
    130                 135     


<210>  9577
<211>  123
<212>  PRT
<213>  Homo Sapiens

<400>  9577

Thr Leu Ser Gly Leu Leu Gly Val Ala Trp Gly Ala Ser Ser Leu Gly 
1               5                   10                  15      


Ala His His Ile His His Phe His Gly Ser Ser Lys His His Ser Val 
            20                  25                  30          


Pro Ile Ala Ile Tyr Arg Ser Pro Ala Ser Leu Arg Gly Gly His Ala 
        35                  40                  45              


Gly Thr Thr Tyr Ile Phe Ser Lys Gly Gly Gly Gln Ile Thr Tyr Lys 
    50                  55                  60                  


Trp Pro Pro Asn Asp Arg Pro Ser Thr Arg Ala Asp Arg Leu Ala Ile 
65                  70                  75                  80  


Gly Phe Ser Thr Val Gln Lys Glu Ala Val Leu Val Arg Val Asp Ser 
                85                  90                  95      


Ser Ser Gly Leu Gly Asp Tyr Leu Glu Leu His Ile Ala Phe Glu Ser 
            100                 105                 110         


Phe Thr Ala Ser Arg Ser Ser Ala Ser Arg Cys 
        115                 120             


<210>  9578
<211>  33
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9578

Xaa Phe Gln Arg Asp Gly Arg Ser Asp Phe Pro Phe Ala Ser Ser Leu 
1               5                   10                  15      


Val Pro Pro Ser Thr Gln Asn Ser Cys Pro Gly Thr Ile Ser Val Asn 
            20                  25                  30          


Thr 
    


<210>  9579
<211>  126
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9579

Xaa Pro Glu Leu Arg Ala Ala Ala Leu Lys Leu Thr Leu Ala Ser Val 
1               5                   10                  15      


Arg Glu Arg Glu Pro Phe Lys Gly Trp Ile Arg Asp Val Arg Val Asn 
            20                  25                  30          


Ser Ser Gln Val Leu Pro Val Asp Ser Gly Glu Val Lys Leu Asp Asp 
        35                  40                  45              


Glu Pro Pro Asn Ser Gly Gly Gly Ser Pro Cys Glu Ala Gly Glu Glu 
    50                  55                  60                  


Gly Glu Gly Gly Val Cys Leu Asn Gly Gly Val Cys Ser Val Val Asp 
65                  70                  75                  80  


Asp Gln Ala Val Cys Asp Cys Ser Arg Thr Gly Phe Arg Gly Lys Asp 
                85                  90                  95      


Cys Ser Gln Gly Leu Ala His Leu Met Met Gly Asp Gln Gly Met Gly 
            100                 105                 110         


Ser Val Pro Phe Pro Leu Cys Phe Gln Cys Phe Leu Val Leu 
        115                 120                 125     


<210>  9580
<211>  169
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9580

Xaa Ser Asn Asn Phe Met Gly Cys Leu Lys Glu Val Val Tyr Lys Asn 
1               5                   10                  15      


Asn Asp Val Arg Leu Glu Leu Ser Arg Leu Ala Lys Gln Gly Asp Pro 
            20                  25                  30          


Lys Met Lys Ile His Gly Val Val Ala Phe Lys Cys Glu Asn Val Ala 
        35                  40                  45              


Thr Leu Asp Pro Ile Thr Phe Glu Thr Pro Glu Ser Phe Ile Ser Leu 
    50                  55                  60                  


Pro Lys Trp Asn Ala Lys Lys Thr Gly Ser Ile Ser Phe Asp Phe Arg 
65                  70                  75                  80  


Thr Thr Glu Pro Asn Gly Leu Ile Leu Phe Ser His Gly Lys Pro Arg 
                85                  90                  95      


His Gln Lys Asp Ala Lys His Pro Gln Met Ile Lys Val Asp Phe Phe 
            100                 105                 110         


Ala Ile Glu Met Leu Asp Gly His Leu Tyr Leu Leu Leu Asp Met Gly 
        115                 120                 125             


Ser Gly Thr Ile Lys Ile Lys Ala Leu Leu Lys Lys Val Asn Asp Gly 
    130                 135                 140                 


Glu Trp Tyr His Val Asp Phe Gln Arg Asp Gly Arg Ser Gly Gln Met 
145                 150                 155                 160 


Ala Gly Asp His Thr Arg Leu Glu Phe 
                165                 


<210>  9581
<211>  155
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9581

Xaa Val Phe Ser Gly Leu Phe Val Gly Gly Leu Pro Pro Glu Leu Arg 
1               5                   10                  15      


Ala Ala Ala Leu Lys Leu Thr Leu Ala Ser Val Arg Glu Arg Glu Pro 
            20                  25                  30          


Phe Lys Gly Trp Ile Arg Asp Val Arg Val Asn Ser Ser Gln Val Leu 
        35                  40                  45              


Pro Val Asp Ser Gly Glu Val Lys Leu Asp Asp Glu Pro Pro Asn Ser 
    50                  55                  60                  


Gly Gly Gly Ser Pro Cys Glu Ala Gly Glu Glu Gly Glu Gly Gly Val 
65                  70                  75                  80  


Cys Leu Asn Gly Gly Val Cys Ser Val Val Asp Asp Gln Ala Val Cys 
                85                  90                  95      


Asp Cys Ser Arg Thr Gly Phe Arg Gly Lys Asp Cys Ser Gln Glu Asp 
            100                 105                 110         


Asn Asn Val Glu Gly Leu Ala His Leu Met Met Gly Asp Gln Gly Lys 
        115                 120                 125             


Ser Lys Glu Leu Met Leu Ile Leu Leu Cys Ser Ile Thr Thr Gln Gly 
    130                 135                 140                 


Leu Glu Thr Ala Lys Ser Leu Ile Met Cys Thr 
145                 150                 155 


<210>  9582
<211>  276
<212>  PRT
<213>  Homo Sapiens

<400>  9582

Leu Leu Leu Leu Leu Leu Gly Ala Ala Glu Gly Ala Arg Val Ser Ser 
1               5                   10                  15      


Ser Leu Ser Thr Thr His His Val His His Phe His Ser Lys His Gly 
            20                  25                  30          


Thr Val Pro Ile Ala Ile Asn Arg Met Pro Phe Leu Thr Arg Gly Gly 
        35                  40                  45              


His Ala Gly Thr Thr Tyr Ile Phe Gly Lys Gly Gly Ala Leu Ile Thr 
    50                  55                  60                  


Tyr Thr Trp Pro Pro Asn Asp Arg Pro Ser Thr Arg Met Asp Arg Leu 
65                  70                  75                  80  


Ala Val Gly Phe Ser Thr His Gln Arg Ser Ala Val Leu Val Arg Val 
                85                  90                  95      


Asp Ser Ala Ser Gly Leu Gly Asp Tyr Leu Gln Leu His Ile Asp Gln 
            100                 105                 110         


Gly Thr Val Gly Val Ile Phe Asn Val Gly Thr Asp Asp Ile Thr Ile 
        115                 120                 125             


Asp Glu Pro Asn Ala Ile Val Ser Asp Gly Lys Tyr His Val Val Arg 
    130                 135                 140                 


Phe Thr Arg Ser Gly Gly Asn Ala Thr Leu Gln Val Asp Ser Trp Pro 
145                 150                 155                 160 


Val Asn Glu Arg Tyr Pro Ala Gly Arg Gln Leu Thr Ile Phe Asn Ser 
                165                 170                 175     


Gln Ala Ala Ile Lys Ile Gly Gly Arg Asp Gln Gly Arg Pro Phe Gln 
            180                 185                 190         


Gly Gln Val Ser Gly Leu Tyr Tyr Asn Gly Leu Lys Val Leu Ala Leu 
        195                 200                 205             


Ala Ala Glu Ser Asp Pro Asn Val Arg Thr Glu Gly His Leu Arg Leu 
    210                 215                 220                 


Val Gly Glu Gly Pro Ser Val Leu Leu Ser Ala Glu Thr Thr Ala Thr 
225                 230                 235                 240 


Thr Leu Leu Ala Asp Met Ala Thr Thr Ile Met Glu Thr Thr Thr Thr 
                245                 250                 255     


Met Ala Thr Thr Thr Thr Arg Arg Gly Arg Ser Pro Thr Leu Arg Asp 
            260                 265                 270         


Ser Thr Thr Gln 
        275     


<210>  9583
<211>  1712
<212>  PRT
<213>  Homo Sapiens

<400>  9583

Met Ala Ser Gly Ser Arg Trp Arg Pro Thr Pro Pro Pro Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ala Leu Ala Ala Arg Ala Asp Gly Leu Glu Phe Gly 
            20                  25                  30          


Gly Gly Pro Gly Gln Trp Ala Arg Tyr Ala Arg Trp Ala Gly Ala Ala 
        35                  40                  45              


Ser Ser Gly Glu Leu Ser Phe Ser Leu Arg Thr Asn Ala Thr Arg Ala 
    50                  55                  60                  


Leu Leu Leu Tyr Leu Asp Asp Gly Gly Asp Cys Asp Phe Leu Glu Leu 
65                  70                  75                  80  


Leu Leu Val Asp Gly Arg Leu Arg Leu Arg Phe Thr Leu Ser Cys Ala 
                85                  90                  95      


Glu Pro Ala Thr Leu Gln Leu Asp Thr Pro Val Ala Asp Asp Arg Trp 
            100                 105                 110         


His Met Val Leu Leu Thr Arg Asp Ala Arg Arg Thr Ala Leu Ala Val 
        115                 120                 125             


Asp Gly Glu Ala Arg Ala Ala Glu Val Arg Ser Lys Arg Arg Glu Met 
    130                 135                 140                 


Gln Val Ala Ser Asp Leu Phe Val Gly Gly Ile Pro Pro Asp Val Arg 
145                 150                 155                 160 


Leu Ser Ala Leu Thr Leu Ser Thr Val Lys Tyr Glu Pro Pro Phe Arg 
                165                 170                 175     


Gly Leu Leu Ala Asn Leu Lys Leu Gly Glu Arg Pro Pro Ala Leu Leu 
            180                 185                 190         


Gly Ser Gln Gly Leu Arg Gly Ala Thr Ala Asp Pro Leu Cys Ala Pro 
        195                 200                 205             


Ala Arg Asn Pro Cys Ala Asn Gly Gly Leu Cys Thr Val Leu Ala Pro 
    210                 215                 220                 


Gly Glu Val Gly Cys Asp Cys Ser His Thr Gly Phe Gly Gly Lys Phe 
225                 230                 235                 240 


Cys Ser Glu Glu Glu His Pro Met Glu Gly Pro Ala His Leu Thr Leu 
                245                 250                 255     


Asn Ser Glu Val Gly Ser Leu Leu Phe Ser Glu Gly Gly Ala Gly Arg 
            260                 265                 270         


Gly Gly Ala Gly Asp Val His Gln Pro Thr Lys Gly Lys Glu Glu Phe 
        275                 280                 285             


Val Ala Thr Phe Lys Gly Asn Glu Phe Phe Cys Tyr Asp Leu Ser His 
    290                 295                 300                 


Asn Pro Ile Gln Ser Ser Thr Asp Glu Ile Thr Leu Ala Phe Arg Thr 
305                 310                 315                 320 


Leu Gln Arg Asn Gly Leu Met Leu His Thr Gly Lys Ser Ala Asp Tyr 
                325                 330                 335     


Val Asn Leu Ser Leu Lys Ser Gly Ala Val Trp Leu Val Ile Asn Leu 
            340                 345                 350         


Gly Ser Gly Ala Phe Glu Ala Leu Val Glu Pro Val Asn Gly Lys Phe 
        355                 360                 365             


Asn Asp Asn Ala Trp His Asp Val Arg Val Thr Arg Asn Leu Arg Gln 
    370                 375                 380                 


His Ala Gly Ile Gly His Ala Met Val Asn Lys Leu His Tyr Leu Val 
385                 390                 395                 400 


Thr Ile Ser Val Asp Gly Ile Leu Thr Thr Thr Gly Tyr Thr Gln Glu 
                405                 410                 415     


Asp Tyr Thr Met Leu Gly Ser Asp Asp Phe Phe Tyr Ile Gly Gly Ser 
            420                 425                 430         


Pro Asn Thr Ala Asp Leu Pro Gly Ser Pro Val Ser Asn Asn Phe Met 
        435                 440                 445             


Gly Cys Leu Lys Asp Val Val Tyr Lys Asn Asn Asp Phe Lys Leu Glu 
    450                 455                 460                 


Leu Ser Arg Leu Ala Lys Glu Gly Asp Pro Lys Met Lys Leu Gln Gly 
465                 470                 475                 480 


Asp Leu Ser Phe Arg Cys Glu Asp Val Ala Ala Leu Asp Pro Val Thr 
                485                 490                 495     


Phe Glu Ser Pro Glu Ala Phe Val Ala Leu Pro Arg Trp Ser Ala Lys 
            500                 505                 510         


Arg Thr Gly Ser Ile Ser Leu Asp Phe Arg Thr Thr Glu Pro Asn Gly 
        515                 520                 525             


Leu Leu Leu Phe Ser Gln Gly Arg Arg Ala Gly Gly Gly Ala Gly Ser 
    530                 535                 540                 


His Ser Ser Ala Gln Arg Ala Asp Tyr Phe Ala Met Glu Leu Leu Asp 
545                 550                 555                 560 


Gly His Leu Tyr Leu Leu Leu Asp Met Gly Ser Gly Gly Ile Lys Leu 
                565                 570                 575     


Arg Ala Ser Ser Arg Lys Val Asn Asp Gly Glu Trp Cys His Val Asp 
            580                 585                 590         


Phe Gln Arg Asp Gly Arg Lys Gly Ser Ile Ser Val Asn Ser Arg Ser 
        595                 600                 605             


Thr Pro Phe Leu Ala Thr Gly Asp Ser Glu Ile Leu Asp Leu Glu Ser 
    610                 615                 620                 


Glu Leu Tyr Leu Gly Gly Leu Pro Glu Gly Gly Arg Val Asp Leu Pro 
625                 630                 635                 640 


Leu Pro Pro Glu Val Trp Thr Ala Ala Leu Arg Ala Gly Tyr Val Gly 
                645                 650                 655     


Cys Val Arg Asp Leu Phe Ile Asp Gly Arg Ser Arg Asp Leu Arg Gly 
            660                 665                 670         


Leu Ala Glu Ala Gln Gly Ala Val Gly Val Ala Pro Phe Cys Ser Arg 
        675                 680                 685             


Glu Thr Leu Lys Gln Cys Ala Ser Ala Pro Cys Arg Asn Gly Gly Val 
    690                 695                 700                 


Cys Arg Glu Gly Trp Asn Arg Phe Ile Cys Asp Cys Ile Gly Thr Gly 
705                 710                 715                 720 


Phe Leu Gly Arg Val Cys Glu Arg Glu Ala Thr Val Leu Ser Tyr Asp 
                725                 730                 735     


Gly Ser Met Tyr Met Lys Ile Met Leu Pro Asn Ala Met His Thr Glu 
            740                 745                 750         


Ala Glu Asp Val Ser Leu Arg Phe Met Ser Gln Arg Ala Tyr Gly Leu 
        755                 760                 765             


Met Met Ala Thr Thr Ser Arg Glu Ser Ala Asp Thr Leu Arg Leu Glu 
    770                 775                 780                 


Leu Asp Gly Gly Gln Met Lys Leu Thr Val Asn Leu Asp Cys Leu Arg 
785                 790                 795                 800 


Val Gly Cys Ala Pro Ser Lys Gly Pro Glu Thr Leu Phe Ala Gly His 
                805                 810                 815     


Lys Leu Asn Asp Asn Glu Trp His Thr Val Arg Val Val Arg Arg Gly 
            820                 825                 830         


Lys Ser Leu Gln Leu Ser Val Asp Asn Val Thr Val Glu Gly Gln Met 
        835                 840                 845             


Ala Gly Ala His Met Arg Leu Glu Phe His Asn Ile Glu Thr Gly Ile 
    850                 855                 860                 


Met Thr Glu Arg Arg Phe Ile Ser Val Val Pro Ser Asn Phe Ile Gly 
865                 870                 875                 880 


His Leu Ser Gly Leu Val Phe Asn Gly Gln Pro Tyr Met Asp Gln Cys 
                885                 890                 895     


Lys Asp Gly Asp Ile Thr Tyr Cys Glu Leu Asn Ala Arg Phe Gly Leu 
            900                 905                 910         


Arg Ala Ile Val Ala Asp Pro Val Thr Phe Lys Ser Arg Ser Ser Tyr 
        915                 920                 925             


Leu Ala Leu Ala Thr Leu Gln Ala Tyr Ala Ser Met His Leu Phe Phe 
    930                 935                 940                 


Gln Phe Lys Thr Thr Ala Pro Asp Gly Leu Leu Leu Phe Asn Ser Gly 
945                 950                 955                 960 


Asn Gly Asn Asp Phe Ile Val Ile Glu Leu Val Lys Gly Tyr Ile His 
                965                 970                 975     


Tyr Val Phe Asp Leu Gly Asn Gly Pro Ser Leu Met Lys Gly Asn Ser 
            980                 985                 990         


Asp Lys Pro Val Asn Asp Asn Gln  Trp His Asn Val Val  Val Ser Arg 
        995                 1000                 1005             


Asp Pro  Gly Asn Val His Thr  Leu Lys Ile Asp Ser  Arg Thr Val 
    1010                 1015                 1020             


Thr Gln  His Ser Asn Gly Ala  Arg Asn Leu Asp Leu  Lys Gly Glu 
    1025                 1030                 1035             


Leu Tyr  Ile Gly Gly Leu Ser  Lys Asn Met Phe Ser  Asn Leu Pro 
    1040                 1045                 1050             


Lys Leu  Val Ala Ser Arg Asp  Gly Phe Gln Gly Cys  Leu Ala Ser 
    1055                 1060                 1065             


Val Asp  Leu Asn Gly Arg Leu  Pro Asp Leu Ile Ala  Asp Ala Leu 
    1070                 1075                 1080             


His Arg  Ile Gly Gln Val Glu  Arg Gly Cys Asp Gly  Pro Ser Thr 
    1085                 1090                 1095             


Thr Cys  Thr Glu Glu Ser Cys  Ala Asn Gln Gly Val  Cys Leu Gln 
    1100                 1105                 1110             


Gln Trp  Asp Gly Phe Thr Cys  Asp Cys Thr Met Thr  Ser Tyr Gly 
    1115                 1120                 1125             


Gly Pro  Val Cys Asn Asp Pro  Gly Thr Thr Tyr Ile  Phe Gly Lys 
    1130                 1135                 1140             


Gly Gly  Ala Leu Ile Thr Tyr  Thr Trp Pro Pro Asn  Asp Arg Pro 
    1145                 1150                 1155             


Ser Thr  Arg Met Asp Arg Leu  Ala Val Gly Phe Ser  Thr His Gln 
    1160                 1165                 1170             


Arg Ser  Ala Val Leu Val Arg  Val Asp Ser Ala Ser  Gly Leu Gly 
    1175                 1180                 1185             


Asp Tyr  Leu Gln Leu His Ile  Asp Gln Gly Thr Val  Gly Val Ile 
    1190                 1195                 1200             


Phe Asn  Val Gly Thr Asp Asp  Ile Thr Ile Asp Glu  Pro Asn Ala 
    1205                 1210                 1215             


Ile Val  Ser Asp Gly Lys Tyr  His Val Val Arg Phe  Thr Arg Ser 
    1220                 1225                 1230             


Gly Gly  Asn Ala Thr Leu Gln  Val Asp Ser Trp Pro  Val Asn Glu 
    1235                 1240                 1245             


Arg Tyr  Pro Ala Gly Asn Phe  Asp Asn Glu Arg Leu  Ala Ile Ala 
    1250                 1255                 1260             


Arg Gln  Arg Ile Pro Tyr Arg  Leu Gly Arg Val Val  Asp Glu Trp 
    1265                 1270                 1275             


Leu Leu  Asp Lys Gly Arg Gln  Leu Thr Ile Phe Asn  Ser Gln Ala 
    1280                 1285                 1290             


Ala Ile  Lys Ile Gly Gly Arg  Asp Gln Gly Arg Pro  Phe Gln Gly 
    1295                 1300                 1305             


Gln Val  Ser Gly Leu Tyr Tyr  Asn Gly Leu Lys Val  Leu Ala Leu 
    1310                 1315                 1320             


Ala Ala  Glu Ser Asp Pro Asn  Val Arg Thr Glu Gly  His Leu Arg 
    1325                 1330                 1335             


Leu Val  Gly Glu Gly Pro Ser  Val Leu Leu Ser Ala  Glu Thr Thr 
    1340                 1345                 1350             


Ala Thr  Thr Leu Leu Ala Asp  Met Ala Thr Thr Ile  Met Glu Thr 
    1355                 1360                 1365             


Thr Thr  Thr Met Ala Thr Thr  Thr Thr Arg Arg Gly  Arg Ser Pro 
    1370                 1375                 1380             


Thr Leu  Arg Asp Ser Thr Thr  Gln Asn Thr Asp Asp  Leu Leu Val 
    1385                 1390                 1395             


Ala Ser  Ala Glu Cys Pro Ser  Asp Asp Glu Asp Leu  Glu Glu Cys 
    1400                 1405                 1410             


Glu Pro  Ser Thr Gly Gly Glu  Leu Ile Leu Pro Ile  Ile Thr Glu 
    1415                 1420                 1425             


Asp Ser  Leu Asp Pro Pro Pro  Val Ala Thr Arg Ser  Pro Phe Val 
    1430                 1435                 1440             


Pro Pro  Pro Pro Thr Phe Tyr  Pro Phe Leu Thr Gly  Val Gly Ala 
    1445                 1450                 1455             


Thr Gln  Asp Thr Leu Pro Pro  Pro Ala Ala Arg Arg  Pro Pro Ser 
    1460                 1465                 1470             


Gly Gly  Pro Cys Gln Ala Glu  Arg Asp Asp Ser Asp  Cys Glu Glu 
    1475                 1480                 1485             


Pro Ile  Glu Ala Ser Gly Phe  Ala Ser Gly Glu Val  Phe Asp Ser 
    1490                 1495                 1500             


Ser Leu  Pro Pro Thr Asp Asp  Glu Asp Phe Tyr Thr  Thr Phe Pro 
    1505                 1510                 1515             


Leu Val  Thr Asp Arg Thr Thr  Leu Leu Ser Pro Arg  Lys Pro Ala 
    1520                 1525                 1530             


Pro Arg  Pro Asn Leu Arg Thr  Asp Gly Ala Thr Gly  Ala Pro Gly 
    1535                 1540                 1545             


Val Leu  Phe Ala Pro Ser Ala  Pro Ala Pro Asn Leu  Pro Ala Gly 
    1550                 1555                 1560             


Lys Met  Asn His Arg Asp Pro  Leu Gln Pro Leu Leu  Glu Asn Pro 
    1565                 1570                 1575             


Pro Leu  Gly Pro Gly Ala Pro  Thr Ser Phe Glu Pro  Arg Arg Pro 
    1580                 1585                 1590             


Pro Pro  Leu Arg Pro Gly Val  Thr Ser Ala Pro Gly  Phe Pro His 
    1595                 1600                 1605             


Leu Pro  Thr Ala Asn Pro Thr  Gly Pro Gly Glu Arg  Gly Pro Pro 
    1610                 1615                 1620             


Gly Ala  Val Glu Val Ile Arg  Glu Ser Ser Ser Thr  Thr Gly Met 
    1625                 1630                 1635             


Val Val  Gly Ile Val Ala Ala  Ala Ala Leu Cys Ile  Leu Ile Leu 
    1640                 1645                 1650             


Leu Tyr  Ala Met Tyr Lys Tyr  Arg Asn Arg Asp Glu  Gly Ser Tyr 
    1655                 1660                 1665             


Gln Val  Asp Gln Ser Arg Asn  Tyr Ile Ser Asn Ser  Ala Gln Ser 
    1670                 1675                 1680             


Asn Gly  Ala Val Val Lys Glu  Lys Ala Pro Ala Ala  Pro Lys Thr 
    1685                 1690                 1695             


Pro Ser  Lys Ala Lys Lys Asn  Lys Asp Lys Glu Tyr  Tyr Val 
    1700                 1705                 1710         


<210>  9584
<211>  1642
<212>  PRT
<213>  Homo Sapiens

<400>  9584

Met Ala Ser Gly Ser Arg Trp Arg Pro Thr Pro Pro Pro Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ala Leu Ala Ala Arg Ala Asp Gly Leu Glu Phe Gly 
            20                  25                  30          


Gly Gly Pro Gly Gln Trp Ala Arg Tyr Ala Arg Trp Ala Gly Ala Ala 
        35                  40                  45              


Ser Ser Gly Glu Leu Ser Phe Ser Leu Arg Thr Asn Ala Thr Arg Ala 
    50                  55                  60                  


Leu Leu Leu Tyr Leu Asp Asp Gly Gly Asp Cys Asp Phe Leu Glu Leu 
65                  70                  75                  80  


Leu Leu Val Asp Gly Arg Leu Arg Leu Arg Phe Thr Leu Ser Cys Ala 
                85                  90                  95      


Glu Pro Ala Thr Leu Gln Leu Asp Thr Pro Val Ala Asp Asp Arg Trp 
            100                 105                 110         


His Met Val Leu Leu Thr Arg Asp Ala Arg Arg Thr Ala Leu Ala Val 
        115                 120                 125             


Asp Gly Glu Ala Arg Ala Ala Glu Val Arg Ser Lys Arg Arg Glu Met 
    130                 135                 140                 


Gln Val Ala Ser Asp Leu Phe Val Gly Gly Ile Pro Pro Asp Val Arg 
145                 150                 155                 160 


Leu Ser Ala Leu Thr Leu Ser Thr Val Lys Tyr Glu Pro Pro Phe Arg 
                165                 170                 175     


Gly Leu Leu Ala Asn Leu Lys Leu Gly Glu Arg Pro Pro Ala Leu Leu 
            180                 185                 190         


Gly Ser Gln Gly Leu Arg Gly Ala Thr Ala Asp Pro Leu Cys Ala Pro 
        195                 200                 205             


Ala Arg Asn Pro Cys Ala Asn Gly Gly Leu Cys Thr Val Leu Ala Pro 
    210                 215                 220                 


Gly Glu Val Gly Cys Asp Cys Ser His Thr Gly Phe Gly Gly Lys Phe 
225                 230                 235                 240 


Cys Ser Glu Glu Glu His Pro Met Glu Gly Pro Ala His Leu Thr Leu 
                245                 250                 255     


Asn Ser Glu Gly Lys Glu Glu Phe Val Ala Thr Phe Lys Gly Asn Glu 
            260                 265                 270         


Phe Phe Cys Tyr Asp Leu Ser His Asn Pro Ile Gln Ser Ser Thr Asp 
        275                 280                 285             


Glu Ile Thr Leu Ala Phe Arg Thr Leu Gln Arg Asn Gly Leu Met Leu 
    290                 295                 300                 


His Thr Gly Lys Ser Ala Asp Tyr Val Asn Leu Ser Leu Lys Ser Gly 
305                 310                 315                 320 


Ala Val Trp Leu Val Ile Asn Leu Gly Ser Gly Ala Phe Glu Ala Leu 
                325                 330                 335     


Val Glu Pro Val Asn Gly Lys Phe Asn Asp Asn Ala Trp His Asp Val 
            340                 345                 350         


Arg Val Thr Arg Asn Leu Arg Gln His Ala Gly Ile Gly His Ala Met 
        355                 360                 365             


Val Thr Ile Ser Val Asp Gly Ile Leu Thr Thr Thr Gly Tyr Thr Gln 
    370                 375                 380                 


Glu Asp Tyr Thr Met Leu Gly Ser Asp Asp Phe Phe Tyr Ile Gly Gly 
385                 390                 395                 400 


Ser Pro Asn Thr Ala Asp Leu Pro Gly Ser Pro Val Ser Asn Asn Phe 
                405                 410                 415     


Met Gly Cys Leu Lys Asp Val Val Tyr Lys Asn Asn Asp Phe Lys Leu 
            420                 425                 430         


Glu Leu Ser Arg Leu Ala Lys Glu Gly Asp Pro Lys Met Lys Leu Gln 
        435                 440                 445             


Gly Asp Leu Ser Phe Arg Cys Glu Asp Val Ala Ala Leu Asp Pro Val 
    450                 455                 460                 


Thr Phe Glu Ser Pro Glu Ala Phe Val Ala Leu Pro Arg Trp Ser Ala 
465                 470                 475                 480 


Lys Arg Thr Gly Ser Ile Ser Leu Asp Phe Arg Thr Thr Glu Pro Asn 
                485                 490                 495     


Gly Leu Leu Leu Phe Ser Gln Gly Arg Arg Ala Gly Gly Gly Ala Gly 
            500                 505                 510         


Ser His Ser Ser Ala Gln Arg Ala Asp Tyr Phe Ala Met Glu Leu Leu 
        515                 520                 525             


Asp Gly His Leu Tyr Leu Leu Leu Asp Met Gly Ser Gly Gly Ile Lys 
    530                 535                 540                 


Leu Arg Ala Ser Ser Arg Lys Val Asn Asp Gly Glu Trp Cys His Val 
545                 550                 555                 560 


Asp Phe Gln Arg Asp Gly Arg Lys Gly Ser Ile Ser Val Asn Ser Arg 
                565                 570                 575     


Ser Thr Pro Phe Leu Ala Thr Gly Asp Ser Glu Ile Leu Asp Leu Glu 
            580                 585                 590         


Ser Glu Leu Tyr Leu Gly Gly Leu Pro Glu Gly Gly Arg Val Asp Leu 
        595                 600                 605             


Pro Leu Pro Pro Glu Val Trp Thr Ala Ala Leu Arg Ala Gly Tyr Val 
    610                 615                 620                 


Gly Cys Val Arg Asp Leu Phe Ile Asp Gly Arg Ser Arg Asp Leu Arg 
625                 630                 635                 640 


Gly Leu Ala Glu Ala Gln Gly Ala Val Gly Val Ala Pro Phe Cys Ser 
                645                 650                 655     


Arg Glu Thr Leu Lys Gln Cys Ala Ser Ala Pro Cys Arg Asn Gly Gly 
            660                 665                 670         


Val Cys Arg Glu Gly Trp Asn Arg Phe Ile Cys Asp Cys Ile Gly Thr 
        675                 680                 685             


Gly Phe Leu Gly Arg Val Cys Glu Arg Glu Ala Thr Val Leu Ser Tyr 
    690                 695                 700                 


Asp Gly Ser Met Tyr Met Lys Ile Met Leu Pro Asn Ala Met His Thr 
705                 710                 715                 720 


Glu Ala Glu Asp Val Ser Leu Arg Phe Met Ser Gln Arg Ala Tyr Gly 
                725                 730                 735     


Leu Met Met Ala Thr Thr Ser Arg Glu Ser Ala Asp Thr Leu Arg Leu 
            740                 745                 750         


Glu Leu Asp Gly Gly Gln Met Lys Leu Thr Val Asn Leu Gly Lys Gly 
        755                 760                 765             


Pro Glu Thr Leu Phe Ala Gly His Lys Leu Asn Asp Asn Glu Trp His 
    770                 775                 780                 


Thr Val Arg Val Val Arg Arg Gly Lys Ser Leu Gln Leu Ser Val Asp 
785                 790                 795                 800 


Asn Val Thr Val Glu Gly Gln Met Ala Gly Ala His Met Arg Leu Glu 
                805                 810                 815     


Phe His Asn Ile Glu Thr Gly Ile Met Thr Glu Arg Arg Phe Ile Ser 
            820                 825                 830         


Val Val Pro Ser Asn Phe Ile Gly His Leu Ser Gly Leu Val Phe Asn 
        835                 840                 845             


Gly Gln Pro Tyr Met Asp Gln Cys Lys Asp Gly Asp Ile Thr Tyr Cys 
    850                 855                 860                 


Glu Leu Asn Ala Arg Phe Gly Leu Arg Ala Ile Val Ala Asp Pro Val 
865                 870                 875                 880 


Thr Phe Lys Ser Arg Ser Ser Tyr Leu Ala Leu Ala Thr Leu Gln Ala 
                885                 890                 895     


Tyr Ala Ser Met His Leu Phe Phe Gln Phe Lys Thr Thr Ala Pro Asp 
            900                 905                 910         


Gly Leu Leu Leu Phe Asn Ser Gly Asn Gly Asn Asp Phe Ile Val Ile 
        915                 920                 925             


Glu Leu Val Lys Gly Tyr Ile His Tyr Val Phe Asp Leu Gly Asn Gly 
    930                 935                 940                 


Pro Ser Leu Met Lys Gly Asn Ser Asp Lys Pro Val Asn Asp Asn Gln 
945                 950                 955                 960 


Trp His Asn Val Val Val Ser Arg Asp Pro Gly Asn Val His Thr Leu 
                965                 970                 975     


Lys Ile Asp Ser Arg Thr Val Thr Gln His Ser Asn Gly Ala Arg Asn 
            980                 985                 990         


Leu Asp Leu Lys Gly Glu Leu Tyr  Ile Gly Gly Leu Ser  Lys Asn Met 
        995                 1000                 1005             


Phe Ser  Asn Leu Pro Lys Leu  Val Ala Ser Arg Asp  Gly Phe Gln 
    1010                 1015                 1020             


Gly Cys  Leu Ala Ser Val Asp  Leu Asn Gly Arg Leu  Pro Asp Leu 
    1025                 1030                 1035             


Ile Ala  Asp Ala Leu His Arg  Ile Gly Gln Val Glu  Arg Gly Cys 
    1040                 1045                 1050             


Asp Gly  Pro Ser Thr Thr Cys  Thr Glu Glu Ser Cys  Ala Asn Gln 
    1055                 1060                 1065             


Gly Val  Cys Leu Gln Gln Trp  Asp Gly Phe Thr Cys  Asp Cys Thr 
    1070                 1075                 1080             


Met Thr  Ser Tyr Gly Gly Pro  Val Cys Asn Asp Pro  Gly Thr Thr 
    1085                 1090                 1095             


Tyr Ile  Phe Gly Lys Gly Gly  Ala Leu Ile Thr Tyr  Thr Trp Pro 
    1100                 1105                 1110             


Pro Asn  Asp Arg Pro Ser Thr  Arg Met Asp Arg Leu  Ala Val Gly 
    1115                 1120                 1125             


Phe Ser  Thr His Gln Arg Ser  Ala Val Leu Val Arg  Val Asp Ser 
    1130                 1135                 1140             


Ala Ser  Gly Leu Gly Asp Tyr  Leu Gln Leu His Ile  Asp Gln Gly 
    1145                 1150                 1155             


Thr Val  Gly Val Ile Phe Asn  Val Gly Thr Asp Asp  Ile Thr Ile 
    1160                 1165                 1170             


Asp Glu  Pro Asn Ala Ile Val  Ser Asp Gly Lys Tyr  His Val Val 
    1175                 1180                 1185             


Arg Phe  Thr Arg Ser Gly Gly  Asn Ala Thr Leu Gln  Val Asp Ser 
    1190                 1195                 1200             


Trp Pro  Val Asn Glu Arg Tyr  Pro Ala Gly Arg Gln  Leu Thr Ile 
    1205                 1210                 1215             


Phe Asn  Ser Gln Ala Ala Ile  Lys Ile Gly Gly Arg  Asp Gln Gly 
    1220                 1225                 1230             


Arg Pro  Phe Gln Gly Gln Val  Ser Gly Leu Tyr Tyr  Asn Gly Leu 
    1235                 1240                 1245             


Lys Val  Leu Ala Leu Ala Ala  Glu Ser Asp Pro Asn  Val Arg Thr 
    1250                 1255                 1260             


Glu Gly  His Leu Arg Leu Val  Gly Glu Gly Pro Ser  Val Leu Leu 
    1265                 1270                 1275             


Ser Ala  Glu Thr Thr Ala Thr  Thr Leu Leu Ala Asp  Met Ala Thr 
    1280                 1285                 1290             


Thr Ile  Met Glu Thr Thr Thr  Thr Met Ala Thr Thr  Thr Thr Arg 
    1295                 1300                 1305             


Arg Gly  Arg Ser Pro Thr Leu  Arg Asp Ser Thr Thr  Gln Asn Thr 
    1310                 1315                 1320             


Asp Asp  Leu Leu Val Ala Ser  Ala Glu Cys Pro Ser  Asp Asp Glu 
    1325                 1330                 1335             


Asp Leu  Glu Glu Cys Glu Pro  Ser Thr Gly Gly Glu  Leu Ile Leu 
    1340                 1345                 1350             


Pro Ile  Ile Thr Glu Asp Ser  Leu Asp Pro Pro Pro  Val Ala Thr 
    1355                 1360                 1365             


Arg Ser  Pro Phe Val Pro Pro  Pro Pro Thr Phe Tyr  Pro Phe Leu 
    1370                 1375                 1380             


Thr Gly  Val Gly Ala Thr Gln  Asp Thr Leu Pro Pro  Pro Ala Ala 
    1385                 1390                 1395             


Arg Arg  Pro Pro Ser Gly Gly  Pro Cys Gln Ala Glu  Arg Asp Asp 
    1400                 1405                 1410             


Ser Asp  Cys Glu Glu Pro Ile  Glu Ala Ser Gly Phe  Ala Ser Gly 
    1415                 1420                 1425             


Glu Val  Phe Asp Ser Ser Leu  Pro Pro Thr Asp Asp  Glu Asp Phe 
    1430                 1435                 1440             


Tyr Thr  Thr Phe Pro Leu Val  Thr Asp Arg Thr Thr  Leu Leu Ser 
    1445                 1450                 1455             


Pro Arg  Lys Pro Ala Pro Arg  Pro Asn Leu Arg Thr  Asp Gly Ala 
    1460                 1465                 1470             


Thr Gly  Ala Pro Gly Val Leu  Phe Ala Pro Ser Ala  Pro Ala Pro 
    1475                 1480                 1485             


Asn Leu  Pro Ala Gly Lys Met  Asn His Arg Asp Pro  Leu Gln Pro 
    1490                 1495                 1500             


Leu Leu  Glu Asn Pro Pro Leu  Gly Pro Gly Ala Pro  Thr Ser Phe 
    1505                 1510                 1515             


Glu Pro  Arg Arg Pro Pro Pro  Leu Arg Pro Gly Val  Thr Ser Ala 
    1520                 1525                 1530             


Pro Gly  Phe Pro His Leu Pro  Thr Ala Asn Pro Thr  Gly Pro Gly 
    1535                 1540                 1545             


Glu Arg  Gly Pro Pro Gly Ala  Val Glu Val Ile Arg  Glu Ser Ser 
    1550                 1555                 1560             


Ser Thr  Thr Gly Met Val Val  Gly Ile Val Ala Ala  Ala Ala Leu 
    1565                 1570                 1575             


Cys Ile  Leu Ile Leu Leu Tyr  Ala Met Tyr Lys Tyr  Arg Asn Arg 
    1580                 1585                 1590             


Asp Glu  Gly Ser Tyr Gln Val  Asp Gln Ser Arg Asn  Tyr Ile Ser 
    1595                 1600                 1605             


Asn Ser  Ala Gln Ser Asn Gly  Ala Val Val Lys Glu  Lys Ala Pro 
    1610                 1615                 1620             


Ala Ala  Pro Lys Thr Pro Ser  Lys Ala Lys Lys Asn  Lys Asp Lys 
    1625                 1630                 1635             


Glu Tyr  Tyr Val 
    1640         


<210>  9585
<211>  1712
<212>  PRT
<213>  Homo Sapiens

<400>  9585

Met Ala Ser Gly Ser Arg Trp Arg Pro Thr Pro Pro Pro Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ala Leu Ala Ala Arg Ala Asp Gly Leu Glu Phe Gly 
            20                  25                  30          


Gly Gly Pro Gly Gln Trp Ala Arg Tyr Ala Arg Trp Ala Gly Ala Ala 
        35                  40                  45              


Ser Ser Gly Glu Leu Ser Phe Ser Leu Arg Thr Asn Ala Thr Arg Ala 
    50                  55                  60                  


Leu Leu Leu Tyr Leu Asp Asp Gly Gly Asp Cys Asp Phe Leu Glu Leu 
65                  70                  75                  80  


Leu Leu Val Asp Gly Arg Leu Arg Leu Arg Phe Thr Leu Ser Cys Ala 
                85                  90                  95      


Glu Pro Ala Thr Leu Gln Leu Asp Thr Pro Val Ala Asp Asp Arg Trp 
            100                 105                 110         


His Met Val Leu Leu Thr Arg Asp Ala Arg Arg Thr Ala Leu Ala Val 
        115                 120                 125             


Asp Gly Glu Ala Arg Ala Ala Glu Val Arg Ser Lys Arg Arg Glu Met 
    130                 135                 140                 


Gln Val Ala Ser Asp Leu Phe Val Gly Gly Ile Pro Pro Asp Val Arg 
145                 150                 155                 160 


Leu Ser Ala Leu Thr Leu Ser Thr Val Lys Tyr Glu Pro Pro Phe Arg 
                165                 170                 175     


Gly Leu Leu Ala Asn Leu Lys Leu Gly Glu Arg Pro Pro Ala Leu Leu 
            180                 185                 190         


Gly Ser Gln Gly Leu Arg Gly Ala Thr Ala Asp Pro Leu Cys Ala Pro 
        195                 200                 205             


Ala Arg Asn Pro Cys Ala Asn Gly Gly Leu Cys Thr Val Leu Ala Pro 
    210                 215                 220                 


Gly Glu Val Gly Cys Asp Cys Ser His Thr Gly Phe Gly Gly Lys Phe 
225                 230                 235                 240 


Cys Ser Glu Glu Glu His Pro Met Glu Gly Pro Ala His Leu Thr Leu 
                245                 250                 255     


Asn Ser Glu Val Gly Ser Leu Leu Phe Ser Glu Gly Gly Ala Gly Arg 
            260                 265                 270         


Gly Gly Ala Gly Asp Val His Gln Pro Thr Lys Gly Lys Glu Glu Phe 
        275                 280                 285             


Val Ala Thr Phe Lys Gly Asn Glu Phe Phe Cys Tyr Asp Leu Ser His 
    290                 295                 300                 


Asn Pro Ile Gln Ser Ser Thr Asp Glu Ile Thr Leu Ala Phe Arg Thr 
305                 310                 315                 320 


Leu Gln Arg Asn Gly Leu Met Leu His Thr Gly Lys Ser Ala Asp Tyr 
                325                 330                 335     


Val Asn Leu Ser Leu Lys Ser Gly Ala Val Trp Leu Val Ile Asn Leu 
            340                 345                 350         


Gly Ser Gly Ala Phe Glu Ala Leu Val Glu Pro Val Asn Gly Lys Phe 
        355                 360                 365             


Asn Asp Asn Ala Trp His Asp Val Arg Val Thr Arg Asn Leu Arg Gln 
    370                 375                 380                 


His Ala Gly Ile Gly His Ala Met Val Asn Lys Leu His Tyr Leu Val 
385                 390                 395                 400 


Thr Ile Ser Val Asp Gly Ile Leu Thr Thr Thr Gly Tyr Thr Gln Glu 
                405                 410                 415     


Asp Tyr Thr Met Leu Gly Ser Asp Asp Phe Phe Tyr Ile Gly Gly Ser 
            420                 425                 430         


Pro Asn Thr Ala Asp Leu Pro Gly Ser Pro Val Ser Asn Asn Phe Met 
        435                 440                 445             


Gly Cys Leu Lys Asp Val Val Tyr Lys Asn Asn Asp Phe Lys Leu Glu 
    450                 455                 460                 


Leu Ser Arg Leu Ala Lys Glu Gly Asp Pro Lys Met Lys Leu Gln Gly 
465                 470                 475                 480 


Asp Leu Ser Phe Arg Cys Glu Asp Val Ala Ala Leu Asp Pro Val Thr 
                485                 490                 495     


Phe Glu Ser Pro Glu Ala Phe Val Ala Leu Pro Arg Trp Ser Ala Lys 
            500                 505                 510         


Arg Thr Gly Ser Ile Ser Leu Asp Phe Arg Thr Thr Glu Pro Asn Gly 
        515                 520                 525             


Leu Leu Leu Phe Ser Gln Gly Arg Arg Ala Gly Gly Gly Ala Gly Ser 
    530                 535                 540                 


His Ser Ser Ala Gln Arg Ala Asp Tyr Phe Ala Met Glu Leu Leu Asp 
545                 550                 555                 560 


Gly His Leu Tyr Leu Leu Leu Asp Met Gly Ser Gly Gly Ile Lys Leu 
                565                 570                 575     


Arg Ala Ser Ser Arg Lys Val Asn Asp Gly Glu Trp Cys His Val Asp 
            580                 585                 590         


Phe Gln Arg Asp Gly Arg Lys Gly Ser Ile Ser Val Asn Ser Arg Ser 
        595                 600                 605             


Thr Pro Phe Leu Ala Thr Gly Asp Ser Glu Ile Leu Asp Leu Glu Ser 
    610                 615                 620                 


Glu Leu Tyr Leu Gly Gly Leu Pro Glu Gly Gly Arg Val Asp Leu Pro 
625                 630                 635                 640 


Leu Pro Pro Glu Val Trp Thr Ala Ala Leu Arg Ala Gly Tyr Val Gly 
                645                 650                 655     


Cys Val Arg Asp Leu Phe Ile Asp Gly Arg Ser Arg Asp Leu Arg Gly 
            660                 665                 670         


Leu Ala Glu Ala Gln Gly Ala Val Gly Val Ala Pro Phe Cys Ser Arg 
        675                 680                 685             


Glu Thr Leu Lys Gln Cys Ala Ser Ala Pro Cys Arg Asn Gly Gly Val 
    690                 695                 700                 


Cys Arg Glu Gly Trp Asn Arg Phe Ile Cys Asp Cys Ile Gly Thr Gly 
705                 710                 715                 720 


Phe Leu Gly Arg Val Cys Glu Arg Glu Ala Thr Val Leu Ser Tyr Asp 
                725                 730                 735     


Gly Ser Met Tyr Met Lys Ile Met Leu Pro Asn Ala Met His Thr Glu 
            740                 745                 750         


Ala Glu Asp Val Ser Leu Arg Phe Met Ser Gln Arg Ala Tyr Gly Leu 
        755                 760                 765             


Met Met Ala Thr Thr Ser Arg Glu Ser Ala Asp Thr Leu Arg Leu Glu 
    770                 775                 780                 


Leu Asp Gly Gly Gln Met Lys Leu Thr Val Asn Leu Asp Cys Leu Arg 
785                 790                 795                 800 


Val Gly Cys Ala Pro Ser Lys Gly Pro Glu Thr Leu Phe Ala Gly His 
                805                 810                 815     


Lys Leu Asn Asp Asn Glu Trp His Thr Val Arg Val Val Arg Arg Gly 
            820                 825                 830         


Lys Ser Leu Gln Leu Ser Val Asp Asn Val Thr Val Glu Gly Gln Met 
        835                 840                 845             


Ala Gly Ala His Met Arg Leu Glu Phe His Asn Ile Glu Thr Gly Ile 
    850                 855                 860                 


Met Thr Glu Arg Arg Phe Ile Ser Val Val Pro Ser Asn Phe Ile Gly 
865                 870                 875                 880 


His Leu Ser Gly Leu Val Phe Asn Gly Gln Pro Tyr Met Asp Gln Cys 
                885                 890                 895     


Lys Asp Gly Asp Ile Thr Tyr Cys Glu Leu Asn Ala Arg Phe Gly Leu 
            900                 905                 910         


Arg Ala Ile Val Ala Asp Pro Val Thr Phe Lys Ser Arg Ser Ser Tyr 
        915                 920                 925             


Leu Ala Leu Ala Thr Leu Gln Ala Tyr Ala Ser Met His Leu Phe Phe 
    930                 935                 940                 


Gln Phe Lys Thr Thr Ala Pro Asp Gly Leu Leu Leu Phe Asn Ser Gly 
945                 950                 955                 960 


Asn Gly Asn Asp Phe Ile Val Ile Glu Leu Val Lys Gly Tyr Ile His 
                965                 970                 975     


Tyr Val Phe Asp Leu Gly Asn Gly Pro Ser Leu Met Lys Gly Asn Ser 
            980                 985                 990         


Asp Lys Pro Val Asn Asp Asn Gln  Trp His Asn Val Val  Val Ser Arg 
        995                 1000                 1005             


Asp Pro  Gly Asn Val His Thr  Leu Lys Ile Asp Ser  Arg Thr Val 
    1010                 1015                 1020             


Thr Gln  His Ser Asn Gly Ala  Arg Asn Leu Asp Leu  Lys Gly Glu 
    1025                 1030                 1035             


Leu Tyr  Ile Gly Gly Leu Ser  Lys Asn Met Phe Ser  Asn Leu Pro 
    1040                 1045                 1050             


Lys Leu  Val Ala Ser Arg Asp  Gly Phe Gln Gly Cys  Leu Ala Ser 
    1055                 1060                 1065             


Val Asp  Leu Asn Gly Arg Leu  Pro Asp Leu Ile Ala  Asp Ala Leu 
    1070                 1075                 1080             


His Arg  Ile Gly Gln Val Glu  Arg Gly Cys Asp Gly  Pro Ser Thr 
    1085                 1090                 1095             


Thr Cys  Thr Glu Glu Ser Cys  Ala Asn Gln Gly Val  Cys Leu Gln 
    1100                 1105                 1110             


Gln Trp  Asp Gly Phe Thr Cys  Asp Cys Thr Met Thr  Ser Tyr Gly 
    1115                 1120                 1125             


Gly Pro  Val Cys Asn Asp Pro  Gly Thr Thr Tyr Ile  Phe Gly Lys 
    1130                 1135                 1140             


Gly Gly  Ala Leu Ile Thr Tyr  Thr Trp Pro Pro Asn  Asp Arg Pro 
    1145                 1150                 1155             


Ser Thr  Arg Met Asp Arg Leu  Ala Val Gly Phe Ser  Thr His Gln 
    1160                 1165                 1170             


Arg Ser  Ala Val Leu Val Arg  Val Asp Ser Ala Ser  Gly Leu Gly 
    1175                 1180                 1185             


Asp Tyr  Leu Gln Leu His Ile  Asp Gln Gly Thr Val  Gly Val Ile 
    1190                 1195                 1200             


Phe Asn  Val Gly Thr Asp Asp  Ile Thr Ile Asp Glu  Pro Asn Ala 
    1205                 1210                 1215             


Ile Val  Ser Asp Gly Lys Tyr  His Val Val Arg Phe  Thr Arg Ser 
    1220                 1225                 1230             


Gly Gly  Asn Ala Thr Leu Gln  Val Asp Ser Trp Pro  Val Asn Glu 
    1235                 1240                 1245             


Arg Tyr  Pro Ala Gly Asn Phe  Asp Asn Glu Arg Leu  Ala Ile Ala 
    1250                 1255                 1260             


Arg Gln  Arg Ile Pro Tyr Arg  Leu Gly Arg Val Val  Asp Glu Trp 
    1265                 1270                 1275             


Leu Leu  Asp Lys Gly Arg Gln  Leu Thr Ile Phe Asn  Ser Gln Ala 
    1280                 1285                 1290             


Ala Ile  Lys Ile Gly Gly Arg  Asp Gln Gly Arg Pro  Phe Gln Gly 
    1295                 1300                 1305             


Gln Val  Ser Gly Leu Tyr Tyr  Asn Gly Leu Lys Val  Leu Ala Leu 
    1310                 1315                 1320             


Ala Ala  Glu Ser Asp Pro Asn  Val Arg Thr Glu Gly  His Leu Arg 
    1325                 1330                 1335             


Leu Val  Gly Glu Gly Pro Ser  Val Leu Leu Ser Ala  Glu Thr Thr 
    1340                 1345                 1350             


Ala Thr  Thr Leu Leu Ala Asp  Met Ala Thr Thr Ile  Met Glu Thr 
    1355                 1360                 1365             


Thr Thr  Thr Met Ala Thr Thr  Thr Thr Arg Arg Gly  Arg Ser Pro 
    1370                 1375                 1380             


Thr Leu  Arg Asp Ser Thr Thr  Gln Asn Thr Asp Asp  Leu Leu Val 
    1385                 1390                 1395             


Ala Ser  Ala Glu Cys Pro Ser  Asp Asp Glu Asp Leu  Glu Glu Cys 
    1400                 1405                 1410             


Glu Pro  Ser Thr Gly Gly Glu  Leu Ile Leu Pro Ile  Ile Thr Glu 
    1415                 1420                 1425             


Asp Ser  Leu Asp Pro Pro Pro  Val Ala Thr Arg Ser  Pro Phe Val 
    1430                 1435                 1440             


Pro Pro  Pro Pro Thr Phe Tyr  Pro Phe Leu Thr Gly  Val Gly Ala 
    1445                 1450                 1455             


Thr Gln  Asp Thr Leu Pro Pro  Pro Ala Ala Arg Arg  Pro Pro Ser 
    1460                 1465                 1470             


Gly Gly  Pro Cys Gln Ala Glu  Arg Asp Asp Ser Asp  Cys Glu Glu 
    1475                 1480                 1485             


Pro Ile  Glu Ala Ser Gly Phe  Ala Ser Gly Glu Val  Phe Asp Ser 
    1490                 1495                 1500             


Ser Leu  Pro Pro Thr Asp Asp  Glu Asp Phe Tyr Thr  Thr Phe Pro 
    1505                 1510                 1515             


Leu Val  Thr Asp Arg Thr Thr  Leu Leu Ser Pro Arg  Lys Pro Ala 
    1520                 1525                 1530             


Pro Arg  Pro Asn Leu Arg Thr  Asp Gly Ala Thr Gly  Ala Pro Gly 
    1535                 1540                 1545             


Val Leu  Phe Ala Pro Ser Ala  Pro Ala Pro Asn Leu  Pro Ala Gly 
    1550                 1555                 1560             


Lys Met  Asn His Arg Asp Pro  Leu Gln Pro Leu Leu  Glu Asn Pro 
    1565                 1570                 1575             


Pro Leu  Gly Pro Gly Ala Pro  Thr Ser Phe Glu Pro  Arg Arg Pro 
    1580                 1585                 1590             


Pro Pro  Leu Arg Pro Gly Val  Thr Ser Ala Pro Gly  Phe Pro His 
    1595                 1600                 1605             


Leu Pro  Thr Ala Asn Pro Thr  Gly Pro Gly Glu Arg  Gly Pro Pro 
    1610                 1615                 1620             


Gly Ala  Val Glu Val Ile Arg  Glu Ser Ser Ser Thr  Thr Gly Met 
    1625                 1630                 1635             


Val Val  Gly Ile Val Ala Ala  Ala Ala Leu Cys Ile  Leu Ile Leu 
    1640                 1645                 1650             


Leu Tyr  Ala Met Tyr Lys Tyr  Arg Asn Arg Asp Glu  Gly Ser Tyr 
    1655                 1660                 1665             


Gln Val  Asp Gln Ser Arg Asn  Tyr Ile Ser Asn Ser  Ala Gln Ser 
    1670                 1675                 1680             


Asn Gly  Ala Val Val Lys Glu  Lys Ala Pro Ala Ala  Pro Lys Thr 
    1685                 1690                 1695             


Pro Ser  Lys Ala Lys Lys Asn  Lys Asp Lys Glu Tyr  Tyr Val 
    1700                 1705                 1710         


<210>  9586
<211>  1705
<212>  PRT
<213>  Homo Sapiens

<400>  9586

Met Ala Ser Gly Ser Arg Trp Arg Pro Thr Pro Pro Pro Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ala Leu Ala Ala Arg Ala Asp Gly Leu Glu Phe Gly 
            20                  25                  30          


Gly Gly Pro Gly Gln Trp Ala Arg Tyr Ala Arg Trp Ala Gly Ala Ala 
        35                  40                  45              


Ser Ser Gly Glu Leu Ser Phe Ser Leu Arg Thr Asn Ala Thr Arg Ala 
    50                  55                  60                  


Leu Leu Leu Tyr Leu Asp Asp Gly Gly Asp Cys Asp Phe Leu Glu Leu 
65                  70                  75                  80  


Leu Leu Val Asp Gly Arg Leu Arg Leu Arg Phe Thr Leu Ser Cys Ala 
                85                  90                  95      


Glu Pro Ala Thr Leu Gln Leu Asp Thr Pro Val Ala Asp Asp Arg Trp 
            100                 105                 110         


His Met Val Leu Leu Thr Arg Asp Ala Arg Arg Thr Ala Leu Ala Val 
        115                 120                 125             


Asp Gly Glu Ala Arg Ala Ala Glu Val Arg Ser Lys Arg Arg Glu Met 
    130                 135                 140                 


Gln Val Ala Ser Asp Leu Phe Val Gly Gly Ile Pro Pro Asp Val Arg 
145                 150                 155                 160 


Leu Ser Ala Leu Thr Leu Ser Thr Val Lys Tyr Glu Pro Pro Phe Arg 
                165                 170                 175     


Gly Leu Leu Ala Asn Leu Lys Leu Gly Glu Arg Pro Pro Ala Leu Leu 
            180                 185                 190         


Gly Ser Gln Gly Leu Arg Gly Ala Thr Ala Asp Pro Leu Cys Ala Pro 
        195                 200                 205             


Ala Arg Asn Pro Cys Ala Asn Gly Gly Leu Cys Thr Val Leu Ala Pro 
    210                 215                 220                 


Gly Glu Val Gly Cys Asp Cys Ser His Thr Gly Phe Gly Gly Lys Phe 
225                 230                 235                 240 


Cys Ser Glu Glu Glu His Pro Met Glu Gly Pro Ala His Leu Thr Leu 
                245                 250                 255     


Asn Ser Glu Val Gly Ser Leu Leu Phe Ser Glu Gly Gly Ala Gly Arg 
            260                 265                 270         


Gly Gly Ala Gly Asp Val His Gln Pro Thr Lys Gly Lys Glu Glu Phe 
        275                 280                 285             


Val Ala Thr Phe Lys Gly Asn Glu Phe Phe Cys Tyr Asp Leu Ser His 
    290                 295                 300                 


Asn Pro Ile Gln Ser Ser Thr Asp Glu Ile Thr Leu Ala Phe Arg Thr 
305                 310                 315                 320 


Leu Gln Arg Asn Gly Leu Met Leu His Thr Gly Lys Ser Ala Asp Tyr 
                325                 330                 335     


Val Asn Leu Ser Leu Lys Ser Gly Ala Val Trp Leu Val Ile Asn Leu 
            340                 345                 350         


Gly Ser Gly Ala Phe Glu Ala Leu Val Glu Pro Val Asn Gly Lys Phe 
        355                 360                 365             


Asn Asp Asn Ala Trp His Asp Val Arg Val Thr Arg Asn Leu Arg Gln 
    370                 375                 380                 


His Ala Gly Ile Gly His Ala Met Val Thr Ile Ser Val Asp Gly Ile 
385                 390                 395                 400 


Leu Thr Thr Thr Gly Tyr Thr Gln Glu Asp Tyr Thr Met Leu Gly Ser 
                405                 410                 415     


Asp Asp Phe Phe Tyr Ile Gly Gly Ser Pro Asn Thr Ala Asp Leu Pro 
            420                 425                 430         


Gly Ser Pro Val Ser Asn Asn Phe Met Gly Cys Leu Lys Asp Val Val 
        435                 440                 445             


Tyr Lys Asn Asn Asp Phe Lys Leu Glu Leu Ser Arg Leu Ala Lys Glu 
    450                 455                 460                 


Gly Asp Pro Lys Met Lys Leu Gln Gly Asp Leu Ser Phe Arg Cys Glu 
465                 470                 475                 480 


Asp Val Ala Ala Leu Asp Pro Val Thr Phe Glu Ser Pro Glu Ala Phe 
                485                 490                 495     


Val Ala Leu Pro Arg Trp Ser Ala Lys Arg Thr Gly Ser Ile Ser Leu 
            500                 505                 510         


Asp Phe Arg Thr Thr Glu Pro Asn Gly Leu Leu Leu Phe Ser Gln Gly 
        515                 520                 525             


Arg Arg Ala Gly Gly Gly Ala Gly Ser His Ser Ser Ala Gln Arg Ala 
    530                 535                 540                 


Asp Tyr Phe Ala Met Glu Leu Leu Asp Gly His Leu Tyr Leu Leu Leu 
545                 550                 555                 560 


Asp Met Gly Ser Gly Gly Ile Lys Leu Arg Ala Ser Ser Arg Lys Val 
                565                 570                 575     


Asn Asp Gly Glu Trp Cys His Val Asp Phe Gln Arg Asp Gly Arg Lys 
            580                 585                 590         


Gly Ser Ile Ser Val Asn Ser Arg Ser Thr Pro Phe Leu Ala Thr Gly 
        595                 600                 605             


Asp Ser Glu Ile Leu Asp Leu Glu Ser Glu Leu Tyr Leu Gly Gly Leu 
    610                 615                 620                 


Pro Glu Gly Gly Arg Val Asp Leu Pro Leu Pro Pro Glu Val Trp Thr 
625                 630                 635                 640 


Ala Ala Leu Arg Ala Gly Tyr Val Gly Cys Val Arg Asp Leu Phe Ile 
                645                 650                 655     


Asp Gly Arg Ser Arg Asp Leu Arg Gly Leu Ala Glu Ala Gln Gly Ala 
            660                 665                 670         


Val Gly Val Ala Pro Phe Cys Ser Arg Glu Thr Leu Lys Gln Cys Ala 
        675                 680                 685             


Ser Ala Pro Cys Arg Asn Gly Gly Val Cys Arg Glu Gly Trp Asn Arg 
    690                 695                 700                 


Phe Ile Cys Asp Cys Ile Gly Thr Gly Phe Leu Gly Arg Val Cys Glu 
705                 710                 715                 720 


Arg Glu Ala Thr Val Leu Ser Tyr Asp Gly Ser Met Tyr Met Lys Ile 
                725                 730                 735     


Met Leu Pro Asn Ala Met His Thr Glu Ala Glu Asp Val Ser Leu Arg 
            740                 745                 750         


Phe Met Ser Gln Arg Ala Tyr Gly Leu Met Met Ala Thr Thr Ser Arg 
        755                 760                 765             


Glu Ser Ala Asp Thr Leu Arg Leu Glu Leu Asp Gly Gly Gln Met Lys 
    770                 775                 780                 


Leu Thr Val Asn Leu Asp Cys Leu Arg Val Gly Cys Ala Pro Ser Lys 
785                 790                 795                 800 


Gly Pro Glu Thr Leu Phe Ala Gly His Lys Leu Asn Asp Asn Glu Trp 
                805                 810                 815     


His Thr Val Arg Val Val Arg Arg Gly Lys Ser Leu Gln Leu Ser Val 
            820                 825                 830         


Asp Asn Val Thr Val Glu Gly Gln Met Ala Gly Ala His Met Arg Leu 
        835                 840                 845             


Glu Phe His Asn Ile Glu Thr Gly Ile Met Thr Glu Arg Arg Phe Ile 
    850                 855                 860                 


Ser Val Val Pro Ser Asn Phe Ile Gly His Leu Ser Gly Leu Val Phe 
865                 870                 875                 880 


Asn Gly Gln Pro Tyr Met Asp Gln Cys Lys Asp Gly Asp Ile Thr Tyr 
                885                 890                 895     


Cys Glu Leu Asn Ala Arg Phe Gly Leu Arg Ala Ile Val Ala Asp Pro 
            900                 905                 910         


Val Thr Phe Lys Ser Arg Ser Ser Tyr Leu Ala Leu Ala Thr Leu Gln 
        915                 920                 925             


Ala Tyr Ala Ser Met His Leu Phe Phe Gln Phe Lys Thr Thr Ala Pro 
    930                 935                 940                 


Asp Gly Leu Leu Leu Phe Asn Ser Gly Asn Gly Asn Asp Phe Ile Val 
945                 950                 955                 960 


Ile Glu Leu Val Lys Gly Tyr Ile His Tyr Val Phe Asp Leu Gly Asn 
                965                 970                 975     


Gly Pro Ser Leu Met Lys Gly Asn Ser Asp Lys Pro Val Asn Asp Asn 
            980                 985                 990         


Gln Trp His Asn Val Val Val Ser  Arg Asp Pro Gly Asn  Val His Thr 
        995                 1000                 1005             


Leu Lys  Ile Asp Ser Arg Thr  Val Thr Gln His Ser  Asn Gly Ala 
    1010                 1015                 1020             


Arg Asn  Leu Asp Leu Lys Gly  Glu Leu Tyr Ile Gly  Gly Leu Ser 
    1025                 1030                 1035             


Lys Asn  Met Phe Ser Asn Leu  Pro Lys Leu Val Ala  Ser Arg Asp 
    1040                 1045                 1050             


Gly Phe  Gln Gly Cys Leu Ala  Ser Val Asp Leu Asn  Gly Arg Leu 
    1055                 1060                 1065             


Pro Asp  Leu Ile Ala Asp Ala  Leu His Arg Ile Gly  Gln Val Glu 
    1070                 1075                 1080             


Arg Gly  Cys Asp Gly Pro Ser  Thr Thr Cys Thr Glu  Glu Ser Cys 
    1085                 1090                 1095             


Ala Asn  Gln Gly Val Cys Leu  Gln Gln Trp Asp Gly  Phe Thr Cys 
    1100                 1105                 1110             


Asp Cys  Thr Met Thr Ser Tyr  Gly Gly Pro Val Cys  Asn Asp Pro 
    1115                 1120                 1125             


Gly Thr  Thr Tyr Ile Phe Gly  Lys Gly Gly Ala Leu  Ile Thr Tyr 
    1130                 1135                 1140             


Thr Trp  Pro Pro Asn Asp Arg  Pro Ser Thr Arg Met  Asp Arg Leu 
    1145                 1150                 1155             


Ala Val  Gly Phe Ser Thr His  Gln Arg Ser Ala Val  Leu Val Arg 
    1160                 1165                 1170             


Val Asp  Ser Ala Ser Gly Leu  Gly Asp Tyr Leu Gln  Leu His Ile 
    1175                 1180                 1185             


Asp Gln  Gly Thr Val Gly Val  Ile Phe Asn Val Gly  Thr Asp Asp 
    1190                 1195                 1200             


Ile Thr  Ile Asp Glu Pro Asn  Ala Ile Val Ser Asp  Gly Lys Tyr 
    1205                 1210                 1215             


His Val  Val Arg Phe Thr Arg  Ser Gly Gly Asn Ala  Thr Leu Gln 
    1220                 1225                 1230             


Val Asp  Ser Trp Pro Val Asn  Glu Arg Tyr Pro Ala  Gly Asn Phe 
    1235                 1240                 1245             


Asp Asn  Glu Arg Leu Ala Ile  Ala Arg Gln Arg Ile  Pro Tyr Arg 
    1250                 1255                 1260             


Leu Gly  Arg Val Val Asp Glu  Trp Leu Leu Asp Lys  Gly Arg Gln 
    1265                 1270                 1275             


Leu Thr  Ile Phe Asn Ser Gln  Ala Ala Ile Lys Ile  Gly Gly Arg 
    1280                 1285                 1290             


Asp Gln  Gly Arg Pro Phe Gln  Gly Gln Val Ser Gly  Leu Tyr Tyr 
    1295                 1300                 1305             


Asn Gly  Leu Lys Val Leu Ala  Leu Ala Ala Glu Ser  Asp Pro Asn 
    1310                 1315                 1320             


Val Arg  Thr Glu Gly His Leu  Arg Leu Val Gly Glu  Gly Pro Ser 
    1325                 1330                 1335             


Val Leu  Leu Ser Ala Glu Thr  Thr Ala Thr Thr Leu  Leu Ala Asp 
    1340                 1345                 1350             


Met Ala  Thr Thr Ile Met Glu  Thr Thr Thr Thr Met  Ala Thr Thr 
    1355                 1360                 1365             


Thr Thr  Arg Arg Gly Arg Ser  Pro Thr Leu Arg Asp  Ser Thr Thr 
    1370                 1375                 1380             


Gln Asn  Thr Asp Asp Leu Leu  Val Ala Ser Ala Glu  Cys Pro Ser 
    1385                 1390                 1395             


Asp Asp  Glu Asp Leu Glu Glu  Cys Glu Pro Ser Thr  Gly Gly Glu 
    1400                 1405                 1410             


Leu Ile  Leu Pro Ile Ile Thr  Glu Asp Ser Leu Asp  Pro Pro Pro 
    1415                 1420                 1425             


Val Ala  Thr Arg Ser Pro Phe  Val Pro Pro Pro Pro  Thr Phe Tyr 
    1430                 1435                 1440             


Pro Phe  Leu Thr Gly Val Gly  Ala Thr Gln Asp Thr  Leu Pro Pro 
    1445                 1450                 1455             


Pro Ala  Ala Arg Arg Pro Pro  Ser Gly Gly Pro Cys  Gln Ala Glu 
    1460                 1465                 1470             


Arg Asp  Asp Ser Asp Cys Glu  Glu Pro Ile Glu Ala  Ser Gly Phe 
    1475                 1480                 1485             


Ala Ser  Gly Glu Val Phe Asp  Ser Ser Leu Pro Pro  Thr Asp Asp 
    1490                 1495                 1500             


Glu Asp  Phe Tyr Thr Thr Phe  Pro Leu Val Thr Asp  Arg Thr Thr 
    1505                 1510                 1515             


Leu Leu  Ser Pro Arg Lys Pro  Ala Pro Arg Pro Asn  Leu Arg Thr 
    1520                 1525                 1530             


Asp Gly  Ala Thr Gly Ala Pro  Gly Val Leu Phe Ala  Pro Ser Ala 
    1535                 1540                 1545             


Pro Ala  Pro Asn Leu Pro Ala  Gly Lys Met Asn His  Arg Asp Pro 
    1550                 1555                 1560             


Leu Gln  Pro Leu Leu Glu Asn  Pro Pro Leu Gly Pro  Gly Ala Pro 
    1565                 1570                 1575             


Thr Ser  Phe Glu Pro Arg Arg  Pro Pro Pro Leu Arg  Pro Gly Val 
    1580                 1585                 1590             


Thr Ser  Ala Pro Gly Phe Pro  His Leu Pro Thr Ala  Asn Pro Thr 
    1595                 1600                 1605             


Gly Pro  Gly Glu Arg Gly Pro  Pro Gly Ala Val Glu  Val Ile Arg 
    1610                 1615                 1620             


Glu Ser  Ser Ser Thr Thr Gly  Met Val Val Gly Ile  Val Ala Ala 
    1625                 1630                 1635             


Ala Ala  Leu Cys Ile Leu Ile  Leu Leu Tyr Ala Met  Tyr Lys Tyr 
    1640                 1645                 1650             


Arg Asn  Arg Asp Glu Gly Ser  Tyr Gln Val Asp Gln  Ser Arg Asn 
    1655                 1660                 1665             


Tyr Ile  Ser Asn Ser Ala Gln  Ser Asn Gly Ala Val  Val Lys Glu 
    1670                 1675                 1680             


Lys Ala  Pro Ala Ala Pro Lys  Thr Pro Ser Lys Ala  Lys Lys Asn 
    1685                 1690                 1695             


Lys Asp  Lys Glu Tyr Tyr Val  
    1700                 1705 


<210>  9587
<211>  666
<212>  PRT
<213>  Homo Sapiens

<400>  9587

Met Pro Pro Gly Gly Ser Gly Pro Gly Gly Cys Pro Arg Arg Pro Pro 
1               5                   10                  15      


Ala Leu Ala Gly Pro Leu Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
            20                  25                  30          


Leu Leu Pro Leu Leu Pro Leu Leu Leu Leu Leu Leu Leu Gly Ala Ala 
        35                  40                  45              


Glu Gly Ala Arg Val Ser Ser Ser Leu Ser Thr Thr His His Val His 
    50                  55                  60                  


His Phe His Ser Lys His Gly Thr Val Pro Ile Ala Ile Asn Arg Met 
65                  70                  75                  80  


Pro Phe Leu Thr Arg Gly Gly His Ala Gly Thr Thr Tyr Ile Phe Gly 
                85                  90                  95      


Lys Gly Gly Ala Leu Ile Thr Tyr Thr Trp Pro Pro Asn Asp Arg Pro 
            100                 105                 110         


Ser Thr Arg Met Asp Arg Leu Ala Val Gly Phe Ser Thr His Gln Arg 
        115                 120                 125             


Ser Ala Val Leu Val Arg Val Asp Ser Ala Ser Gly Leu Gly Asp Tyr 
    130                 135                 140                 


Leu Gln Leu His Ile Asp Gln Gly Thr Val Gly Val Ile Phe Asn Val 
145                 150                 155                 160 


Gly Thr Asp Asp Ile Thr Ile Asp Glu Pro Asn Ala Ile Val Ser Asp 
                165                 170                 175     


Gly Lys Tyr His Val Val Arg Phe Thr Arg Ser Gly Gly Asn Ala Thr 
            180                 185                 190         


Leu Gln Val Asp Ser Trp Pro Val Asn Glu Arg Tyr Pro Ala Gly Asn 
        195                 200                 205             


Phe Asp Asn Glu Arg Leu Ala Ile Ala Arg Gln Arg Ile Pro Tyr Arg 
    210                 215                 220                 


Leu Gly Arg Val Val Asp Glu Trp Leu Leu Asp Lys Gly Arg Gln Leu 
225                 230                 235                 240 


Thr Ile Phe Asn Ser Gln Ala Ala Ile Lys Ile Gly Gly Arg Asp Gln 
                245                 250                 255     


Gly Arg Pro Phe Gln Gly Gln Val Ser Gly Leu Tyr Tyr Asn Gly Leu 
            260                 265                 270         


Lys Val Leu Ala Leu Ala Ala Glu Ser Asp Pro Asn Val Arg Thr Glu 
        275                 280                 285             


Gly His Leu Arg Leu Val Gly Glu Gly Pro Ser Val Leu Leu Ser Ala 
    290                 295                 300                 


Glu Thr Thr Ala Thr Thr Leu Leu Ala Asp Met Ala Thr Thr Ile Met 
305                 310                 315                 320 


Glu Thr Thr Thr Thr Met Ala Thr Thr Thr Thr Arg Arg Gly Arg Ser 
                325                 330                 335     


Pro Thr Leu Arg Asp Ser Thr Thr Gln Asn Thr Asp Asp Leu Leu Val 
            340                 345                 350         


Ala Ser Ala Glu Cys Pro Ser Asp Asp Glu Asp Leu Glu Glu Cys Glu 
        355                 360                 365             


Pro Ser Thr Gly Gly Glu Leu Ile Leu Pro Ile Ile Thr Glu Asp Ser 
    370                 375                 380                 


Leu Asp Pro Pro Pro Val Ala Thr Arg Ser Pro Phe Val Pro Pro Pro 
385                 390                 395                 400 


Pro Thr Phe Tyr Pro Phe Leu Thr Gly Val Gly Ala Thr Gln Asp Thr 
                405                 410                 415     


Leu Pro Pro Pro Ala Ala Arg Arg Pro Pro Ser Gly Gly Pro Cys Gln 
            420                 425                 430         


Ala Glu Arg Asp Asp Ser Asp Cys Glu Glu Pro Ile Glu Ala Ser Gly 
        435                 440                 445             


Phe Ala Ser Gly Glu Val Phe Asp Ser Ser Leu Pro Pro Thr Asp Asp 
    450                 455                 460                 


Glu Asp Phe Tyr Thr Thr Phe Pro Leu Val Thr Asp Arg Thr Thr Leu 
465                 470                 475                 480 


Leu Ser Pro Arg Lys Pro Ala Pro Arg Pro Asn Leu Arg Thr Asp Gly 
                485                 490                 495     


Ala Thr Gly Ala Pro Gly Val Leu Phe Ala Pro Ser Ala Pro Ala Pro 
            500                 505                 510         


Asn Leu Pro Ala Gly Lys Met Asn His Arg Asp Pro Leu Gln Pro Leu 
        515                 520                 525             


Leu Glu Asn Pro Pro Leu Gly Pro Gly Ala Pro Thr Ser Phe Glu Pro 
    530                 535                 540                 


Arg Arg Pro Pro Pro Leu Arg Pro Gly Val Thr Ser Ala Pro Gly Phe 
545                 550                 555                 560 


Pro His Leu Pro Thr Ala Asn Pro Thr Gly Pro Gly Glu Arg Gly Pro 
                565                 570                 575     


Pro Gly Ala Val Glu Val Ile Arg Glu Ser Ser Ser Thr Thr Gly Met 
            580                 585                 590         


Val Val Gly Ile Val Ala Ala Ala Ala Leu Cys Ile Leu Ile Leu Leu 
        595                 600                 605             


Tyr Ala Met Tyr Lys Tyr Arg Asn Arg Asp Glu Gly Ser Tyr Gln Val 
    610                 615                 620                 


Asp Gln Ser Arg Asn Tyr Ile Ser Asn Ser Ala Gln Ser Asn Gly Ala 
625                 630                 635                 640 


Val Val Lys Glu Lys Ala Pro Ala Ala Pro Lys Thr Pro Ser Lys Ala 
                645                 650                 655     


Lys Lys Asn Lys Asp Lys Glu Tyr Tyr Val 
            660                 665     


<210>  9588
<211>  293
<212>  PRT
<213>  Homo Sapiens

<400>  9588

Ser Val Ser Pro Ala Ala Thr Cys Gly Gln Pro Val Trp Ser Glu Glu 
1               5                   10                  15      


His Pro Met Glu Gly Pro Ala His Leu Thr Leu Asn Ser Glu Val Gly 
            20                  25                  30          


Ser Leu Leu Phe Ser Glu Gly Gly Ala Gly Arg Gly Gly Ala Gly Asp 
        35                  40                  45              


Val His Gln Pro Thr Lys Gly Lys Glu Glu Phe Val Ala Thr Phe Lys 
    50                  55                  60                  


Gly Asn Glu Phe Phe Cys Tyr Asp Leu Ser His Asn Pro Ile Gln Ser 
65                  70                  75                  80  


Ser Thr Asp Glu Ile Thr Leu Ala Phe Arg Thr Leu Gln Arg Asn Gly 
                85                  90                  95      


Leu Met Leu His Thr Gly Lys Ser Ala Asp Tyr Val Asn Leu Ser Leu 
            100                 105                 110         


Lys Ser Gly Ala Val Trp Leu Val Ile Asn Leu Gly Ser Gly Ala Phe 
        115                 120                 125             


Glu Ala Leu Val Glu Pro Val Asn Gly Lys Phe Asn Asp Asn Ala Trp 
    130                 135                 140                 


His Asp Val Arg Val Thr Arg Asn Leu Arg Gln Val Thr Ile Ser Val 
145                 150                 155                 160 


Asp Gly Ile Leu Thr Thr Thr Gly Tyr Thr Gln Glu Asp Tyr Thr Met 
                165                 170                 175     


Leu Gly Ser Asp Asp Phe Phe Tyr Ile Gly Gly Ser Pro Asn Thr Ala 
            180                 185                 190         


Asp Leu Pro Gly Ser Pro Val Ser Asn Asn Phe Met Gly Cys Leu Lys 
        195                 200                 205             


Asp Val Val Tyr Lys Asn Asn Asp Phe Lys Leu Glu Leu Ser Arg Leu 
    210                 215                 220                 


Ala Lys Glu Gly Asp Pro Lys Met Lys Leu Gln Gly Asp Leu Ser Phe 
225                 230                 235                 240 


Arg Cys Glu Asp Val Ala Ala Leu Asp Pro Val Thr Phe Glu Ser Pro 
                245                 250                 255     


Glu Ala Phe Val Ala Leu Pro Arg Trp Ser Ala Lys Arg Thr Gly Ser 
            260                 265                 270         


Ile Ser Leu Asp Phe Arg Thr Thr Glu Pro Asn Gly Leu Leu Leu Phe 
        275                 280                 285             


Ser Gln Gly Arg Arg 
    290             


<210>  9589
<211>  215
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9589

Xaa Ala Asp Pro Leu Cys Ala Pro Ala Arg Asn Pro Cys Ala Asn Gly 
1               5                   10                  15      


Gly Leu Cys Thr Val Leu Ala Pro Gly Glu Val Gly Cys Asp Cys Ser 
            20                  25                  30          


His Thr Gly Phe Gly Gly Lys Phe Cys Ser Glu Glu Glu His Pro Met 
        35                  40                  45              


Glu Val Gly Ser Leu Leu Phe Ser Glu Gly Gly Ala Gly Arg Gly Gly 
    50                  55                  60                  


Ala Gly Asp Val His Gln Pro Thr Lys Gly Lys Glu Glu Phe Val Ala 
65                  70                  75                  80  


Thr Phe Lys Gly Asn Glu Phe Phe Cys Tyr Asp Leu Ser His Asn Pro 
                85                  90                  95      


Ile Gln Ser Ser Thr Asp Glu Ile Thr Leu Ala Phe Arg Thr Leu Gln 
            100                 105                 110         


Arg Asn Gly Leu Met Leu His Thr Gly Lys Ser Ala Asp Tyr Val Asn 
        115                 120                 125             


Leu Ser Leu Lys Ser Gly Ala Val Trp Leu Val Ile Asn Leu Gly Ser 
    130                 135                 140                 


Gly Ala Phe Glu Ala Leu Val Glu Pro Val Asn Gly Lys Phe Asn Asp 
145                 150                 155                 160 


Asn Ala Trp His Asp Val Arg Val Thr Arg Asn Leu Arg Gln Val Thr 
                165                 170                 175     


Ile Ser Val Asp Gly Ile Leu Thr Thr Thr Gly Tyr Thr Gln Glu Asp 
            180                 185                 190         


Tyr Thr Met Leu Gly Ser Asp Asp Phe Phe Tyr Ile Gly Gly Ser Pro 
        195                 200                 205             


Asn Thr Ala Asp Leu Pro Gly 
    210                 215 


<210>  9590
<211>  206
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9590

Xaa Cys Ser Glu Glu Glu His Pro Met Glu Gly Pro Ala His Leu Thr 
1               5                   10                  15      


Leu Asn Ser Glu Val Gly Ser Leu Leu Phe Ser Glu Gly Gly Ala Gly 
            20                  25                  30          


Arg Gly Gly Ala Gly Asp Val His Gln Pro Thr Lys Gly Lys Glu Glu 
        35                  40                  45              


Phe Val Ala Thr Phe Lys Gly Asn Glu Phe Phe Cys Tyr Asp Leu Ser 
    50                  55                  60                  


His Asn Pro Ile Gln Ser Ser Thr Asp Glu Ile Thr Leu Ala Phe Arg 
65                  70                  75                  80  


Thr Leu Gln Arg Asn Gly Leu Met Leu His Thr Gly Lys Ser Ala Asp 
                85                  90                  95      


Tyr Val Asn Leu Ser Leu Lys Ser Gly Ala Val Trp Leu Val Ile Asn 
            100                 105                 110         


Leu Gly Ser Gly Ala Phe Glu Ala Leu Val Glu Pro Val Asn Gly Lys 
        115                 120                 125             


Phe Asn Asp Asn Ala Trp His Asp Val Arg Val Thr Arg Asn Leu Arg 
    130                 135                 140                 


Gln Val Thr Ile Ser Val Asp Gly Ile Leu Thr Thr Thr Gly Tyr Thr 
145                 150                 155                 160 


Gln Glu Asp Tyr Thr Met Leu Gly Ser Asp Asp Phe Phe Tyr Ile Gly 
                165                 170                 175     


Gly Ser Pro Asn Thr Ala Asp Leu Pro Gly Ser Pro Val Ser Asn Asn 
            180                 185                 190         


Phe Met Gly Cys Leu Lys Asp Val Val Tyr Lys Asn Asn Asp 
        195                 200                 205     


<210>  9591
<211>  331
<212>  PRT
<213>  Homo Sapiens

<400>  9591

Met Asp Arg Ala Ala Val Ala Arg Val Gly Ala Val Ala Ser Ala Ser 
1               5                   10                  15      


Val Cys Ala Leu Val Ala Gly Val Val Leu Ala Gln Tyr Ile Phe Thr 
            20                  25                  30          


Leu Lys Arg Lys Thr Gly Arg Lys Thr Lys Ile Ile Glu Met Met Pro 
        35                  40                  45              


Glu Phe Gln Lys Ser Ser Val Arg Ile Lys Asn Pro Thr Arg Val Glu 
    50                  55                  60                  


Glu Ile Ile Cys Gly Leu Ile Lys Gly Gly Ala Ala Lys Leu Gln Ile 
65                  70                  75                  80  


Ile Thr Asp Phe Asp Met Thr Leu Ser Arg Phe Ser Tyr Lys Gly Lys 
                85                  90                  95      


Arg Cys Pro Thr Cys His Asn Ile Ile Asp Asn Cys Lys Leu Val Thr 
            100                 105                 110         


Asp Glu Cys Arg Lys Lys Leu Leu Gln Leu Lys Glu Lys Tyr Tyr Ala 
        115                 120                 125             


Ile Glu Val Asp Pro Val Leu Thr Val Glu Glu Lys Tyr Pro Tyr Met 
    130                 135                 140                 


Val Glu Trp Tyr Thr Lys Ser His Gly Leu Leu Val Gln Gln Ala Leu 
145                 150                 155                 160 


Pro Lys Ala Lys Leu Lys Glu Ile Val Ala Glu Ser Asp Val Met Leu 
                165                 170                 175     


Lys Glu Gly Tyr Glu Asn Phe Phe Asp Lys Leu Gln Gln His Ser Ile 
            180                 185                 190         


Pro Val Phe Ile Phe Ser Ala Gly Ile Gly Asp Val Leu Glu Glu Val 
        195                 200                 205             


Ile Arg Gln Ala Gly Val Tyr His Pro Asn Val Lys Val Val Ser Asn 
    210                 215                 220                 


Phe Met Asp Phe Asp Glu Thr Gly Val Leu Lys Gly Phe Lys Gly Glu 
225                 230                 235                 240 


Leu Ile His Val Phe Asn Lys His Asp Gly Ala Leu Arg Asn Thr Glu 
                245                 250                 255     


Tyr Phe Asn Gln Leu Lys Asp Asn Ser Asn Ile Ile Leu Leu Gly Asp 
            260                 265                 270         


Ser Gln Gly Asp Leu Arg Met Ala Asp Gly Val Ala Asn Val Glu His 
        275                 280                 285             


Ile Leu Lys Ile Gly Tyr Leu Asn Asp Arg Val Asp Glu Leu Leu Glu 
    290                 295                 300                 


Lys Tyr Met Asp Ser Tyr Asp Ile Val Leu Val Gln Asp Glu Ser Leu 
305                 310                 315                 320 


Glu Val Ala Asn Ser Ile Leu Gln Lys Ile Leu 
                325                 330     


<210>  9592
<211>  331
<212>  PRT
<213>  Homo Sapiens

<400>  9592

Met Asp Arg Ala Ala Val Ala Arg Val Gly Ala Val Ala Ser Ala Ser 
1               5                   10                  15      


Val Cys Ala Leu Val Ala Gly Val Val Leu Ala Gln Tyr Ile Phe Thr 
            20                  25                  30          


Leu Lys Arg Lys Thr Gly Arg Lys Thr Lys Ile Ile Glu Met Met Pro 
        35                  40                  45              


Glu Phe Gln Lys Ser Ser Val Arg Ile Lys Asn Pro Thr Arg Val Glu 
    50                  55                  60                  


Glu Ile Ile Cys Gly Leu Ile Lys Gly Gly Ala Ala Lys Leu Gln Ile 
65                  70                  75                  80  


Ile Thr Asp Phe Asp Met Thr Leu Ser Arg Phe Ser Tyr Lys Gly Lys 
                85                  90                  95      


Arg Cys Pro Thr Cys His Asn Ile Ile Asp Asn Cys Lys Leu Val Thr 
            100                 105                 110         


Asp Glu Cys Arg Lys Lys Leu Leu Gln Leu Lys Glu Lys Tyr Tyr Ala 
        115                 120                 125             


Ile Glu Val Asp Pro Val Leu Thr Val Glu Glu Lys Tyr Pro Tyr Met 
    130                 135                 140                 


Val Glu Trp Tyr Thr Lys Ser His Gly Leu Leu Val Gln Gln Ala Leu 
145                 150                 155                 160 


Pro Lys Ala Lys Leu Lys Glu Ile Val Ala Glu Ser Asp Val Met Leu 
                165                 170                 175     


Lys Glu Gly Tyr Glu Asn Phe Phe Asp Lys Leu Gln Gln His Ser Ile 
            180                 185                 190         


Pro Val Phe Ile Phe Ser Ala Gly Ile Gly Asp Val Leu Glu Glu Val 
        195                 200                 205             


Ile Arg Gln Ala Gly Val Tyr His Pro Asn Val Lys Val Val Ser Asn 
    210                 215                 220                 


Phe Met Asp Phe Asp Glu Thr Gly Val Leu Lys Gly Phe Lys Gly Glu 
225                 230                 235                 240 


Leu Ile His Val Phe Asn Lys His Asp Gly Ala Leu Arg Asn Thr Glu 
                245                 250                 255     


Tyr Phe Asn Gln Leu Lys Asp Asn Ser Asn Ile Ile Leu Leu Gly Asp 
            260                 265                 270         


Ser Gln Gly Asp Leu Arg Met Ala Asp Gly Val Ala Asn Val Glu His 
        275                 280                 285             


Ile Leu Lys Ile Gly Tyr Leu Asn Asp Arg Val Asp Glu Leu Leu Glu 
    290                 295                 300                 


Lys Tyr Met Asp Ser Tyr Asp Ile Val Leu Val Gln Asp Glu Ser Leu 
305                 310                 315                 320 


Glu Val Ala Asn Ser Ile Leu Gln Lys Ile Leu 
                325                 330     


<210>  9593
<211>  42
<212>  PRT
<213>  Homo Sapiens

<400>  9593

Met Pro Glu Phe Gln Lys Ser Ser Val Arg Ile Lys Asn Pro Thr Arg 
1               5                   10                  15      


Val Glu Glu Ile Ile Cys Gly Leu Ile Lys Gly Gly Ala Ala Lys Leu 
            20                  25                  30          


Gln Ile Ile Thr Asp Phe Asp Met Thr Leu 
        35                  40          


<210>  9594
<211>  285
<212>  PRT
<213>  Homo Sapiens

<400>  9594

Met Pro Glu Phe Gln Lys Ser Ser Val Arg Ile Lys Asn Pro Thr Arg 
1               5                   10                  15      


Val Glu Glu Ile Ile Cys Gly Leu Ile Lys Gly Gly Ala Ala Lys Leu 
            20                  25                  30          


Gln Ile Ile Thr Asp Phe Asp Met Thr Leu Ser Arg Phe Ser Tyr Lys 
        35                  40                  45              


Gly Lys Arg Cys Pro Thr Cys His Asn Ile Ile Asp Asn Cys Lys Leu 
    50                  55                  60                  


Val Thr Asp Glu Cys Arg Lys Lys Leu Leu Gln Leu Lys Glu Lys Tyr 
65                  70                  75                  80  


Tyr Ala Ile Glu Val Asp Pro Val Leu Thr Val Glu Glu Lys Tyr Pro 
                85                  90                  95      


Tyr Met Val Glu Trp Tyr Thr Lys Ser His Gly Leu Leu Val Gln Gln 
            100                 105                 110         


Ala Leu Pro Lys Ala Lys Leu Lys Glu Ile Val Ala Glu Ser Asp Val 
        115                 120                 125             


Met Leu Lys Glu Gly Tyr Glu Asn Phe Phe Asp Lys Leu Gln Gln His 
    130                 135                 140                 


Ser Ile Pro Val Phe Ile Phe Ser Ala Gly Ile Gly Asp Val Leu Glu 
145                 150                 155                 160 


Glu Val Ile Arg Gln Ala Gly Val Tyr His Pro Asn Val Lys Val Val 
                165                 170                 175     


Ser Asn Phe Met Asp Phe Asp Glu Thr Gly Val Leu Lys Gly Phe Lys 
            180                 185                 190         


Gly Glu Leu Ile His Val Phe Asn Lys His Asp Gly Ala Leu Arg Asn 
        195                 200                 205             


Thr Glu Tyr Phe Asn Gln Leu Lys Asp Asn Ser Asn Ile Ile Leu Leu 
    210                 215                 220                 


Gly Asp Ser Gln Gly Asp Leu Arg Met Ala Asp Gly Val Ala Asn Val 
225                 230                 235                 240 


Glu His Ile Leu Lys Ile Gly Tyr Leu Asn Asp Arg Val Asp Glu Leu 
                245                 250                 255     


Leu Glu Lys Tyr Met Asp Ser Tyr Asp Ile Val Leu Val Gln Asp Glu 
            260                 265                 270         


Ser Leu Glu Val Ala Asn Ser Ile Leu Gln Lys Ile Leu 
        275                 280                 285 


<210>  9595
<211>  285
<212>  PRT
<213>  Homo Sapiens

<400>  9595

Met Pro Glu Phe Gln Lys Ser Ser Val Arg Ile Lys Asn Pro Thr Arg 
1               5                   10                  15      


Val Glu Glu Ile Ile Cys Gly Leu Ile Lys Gly Gly Ala Ala Lys Leu 
            20                  25                  30          


Gln Ile Ile Thr Asp Phe Asp Met Thr Leu Ser Arg Phe Ser Tyr Lys 
        35                  40                  45              


Gly Lys Arg Cys Pro Thr Cys His Asn Ile Ile Asp Asn Cys Lys Leu 
    50                  55                  60                  


Val Thr Asp Glu Cys Arg Lys Lys Leu Leu Gln Leu Lys Glu Lys Tyr 
65                  70                  75                  80  


Tyr Ala Ile Glu Val Asp Pro Val Leu Thr Val Glu Glu Lys Tyr Pro 
                85                  90                  95      


Tyr Met Val Glu Trp Tyr Thr Lys Ser His Gly Leu Leu Val Gln Gln 
            100                 105                 110         


Ala Leu Pro Lys Ala Lys Leu Lys Glu Ile Val Ala Glu Ser Asp Val 
        115                 120                 125             


Met Leu Lys Glu Gly Tyr Glu Asn Phe Phe Asp Lys Leu Gln Gln His 
    130                 135                 140                 


Ser Ile Pro Val Phe Ile Phe Ser Ala Gly Ile Gly Asp Val Leu Glu 
145                 150                 155                 160 


Glu Val Ile Arg Gln Ala Gly Val Tyr His Pro Asn Val Lys Val Val 
                165                 170                 175     


Ser Asn Phe Met Asp Phe Asp Glu Thr Gly Val Leu Lys Gly Phe Lys 
            180                 185                 190         


Gly Glu Leu Ile His Val Phe Asn Lys His Asp Gly Ala Leu Arg Asn 
        195                 200                 205             


Thr Glu Tyr Phe Asn Gln Leu Lys Asp Asn Ser Asn Ile Ile Leu Leu 
    210                 215                 220                 


Gly Asp Ser Gln Gly Asp Leu Arg Met Ala Asp Gly Val Ala Asn Val 
225                 230                 235                 240 


Glu His Ile Leu Lys Ile Gly Tyr Leu Asn Asp Arg Val Asp Glu Leu 
                245                 250                 255     


Leu Glu Lys Tyr Met Asp Ser Tyr Asp Ile Val Leu Val Gln Asp Glu 
            260                 265                 270         


Ser Leu Glu Val Ala Asn Ser Ile Leu Gln Lys Ile Leu 
        275                 280                 285 


<210>  9596
<211>  54
<212>  PRT
<213>  Homo Sapiens

<400>  9596

Met Arg Ala Pro Ser Met Asp Arg Ala Ala Val Ala Arg Val Gly Ala 
1               5                   10                  15      


Val Ala Ser Ala Ser Val Cys Ala Leu Val Ala Gly Val Val Leu Ala 
            20                  25                  30          


Gln Tyr Ile Phe Thr Leu Lys Arg Lys Thr Gly Arg Lys Thr Lys Ile 
        35                  40                  45              


Ile Glu Met Lys Ile Gly 
    50                  


<210>  9597
<211>  336
<212>  PRT
<213>  Homo Sapiens

<400>  9597

Met Arg Ala Pro Ser Met Asp Arg Ala Ala Val Ala Arg Val Gly Ala 
1               5                   10                  15      


Val Ala Ser Ala Ser Val Cys Ala Leu Val Ala Gly Val Val Leu Ala 
            20                  25                  30          


Gln Tyr Ile Phe Thr Leu Lys Arg Lys Thr Gly Arg Lys Thr Lys Ile 
        35                  40                  45              


Ile Glu Met Met Pro Glu Phe Gln Lys Ser Ser Val Arg Ile Lys Asn 
    50                  55                  60                  


Pro Thr Arg Val Glu Glu Ile Ile Cys Gly Leu Ile Lys Gly Gly Ala 
65                  70                  75                  80  


Ala Lys Leu Gln Ile Ile Thr Asp Phe Asp Met Thr Leu Ser Arg Phe 
                85                  90                  95      


Ser Tyr Lys Gly Lys Arg Cys Pro Thr Cys His Asn Ile Ile Asp Asn 
            100                 105                 110         


Cys Lys Leu Val Thr Asp Glu Cys Arg Lys Lys Leu Leu Gln Leu Lys 
        115                 120                 125             


Glu Lys Tyr Tyr Ala Ile Glu Val Asp Pro Val Leu Thr Val Glu Glu 
    130                 135                 140                 


Lys Tyr Pro Tyr Met Val Glu Trp Tyr Thr Lys Ser His Gly Leu Leu 
145                 150                 155                 160 


Val Gln Gln Ala Leu Pro Lys Ala Lys Leu Lys Glu Ile Val Ala Glu 
                165                 170                 175     


Ser Asp Val Met Leu Lys Glu Gly Tyr Glu Asn Phe Phe Asp Lys Leu 
            180                 185                 190         


Gln Gln His Ser Ile Pro Val Phe Ile Phe Ser Ala Gly Ile Gly Asp 
        195                 200                 205             


Val Leu Glu Glu Val Ile Arg Gln Ala Gly Val Tyr His Pro Asn Val 
    210                 215                 220                 


Lys Val Val Ser Asn Phe Met Asp Phe Asp Glu Thr Gly Val Leu Lys 
225                 230                 235                 240 


Gly Phe Lys Gly Glu Leu Ile His Val Phe Asn Lys His Asp Gly Ala 
                245                 250                 255     


Leu Arg Asn Thr Glu Tyr Phe Asn Gln Leu Lys Asp Asn Ser Asn Ile 
            260                 265                 270         


Ile Leu Leu Gly Asp Ser Gln Gly Asp Leu Arg Met Ala Asp Gly Val 
        275                 280                 285             


Ala Asn Val Glu His Ile Leu Lys Ile Gly Tyr Leu Asn Asp Arg Val 
    290                 295                 300                 


Asp Glu Leu Leu Glu Lys Tyr Met Asp Ser Tyr Asp Ile Val Leu Val 
305                 310                 315                 320 


Gln Asp Glu Ser Leu Glu Val Ala Asn Ser Ile Leu Gln Lys Ile Leu 
                325                 330                 335     


<210>  9598
<211>  297
<212>  PRT
<213>  Homo Sapiens

<400>  9598

Met Thr Asn Gln Glu Ser Ala Val His Val Lys Met Met Pro Glu Phe 
1               5                   10                  15      


Gln Lys Ser Ser Val Arg Ile Lys Asn Pro Thr Arg Val Glu Glu Ile 
            20                  25                  30          


Ile Cys Gly Leu Ile Lys Gly Gly Ala Ala Lys Leu Gln Ile Ile Thr 
        35                  40                  45              


Asp Phe Asp Met Thr Leu Ser Arg Phe Ser Tyr Lys Gly Lys Arg Cys 
    50                  55                  60                  


Pro Thr Cys His Asn Ile Ile Asp Asn Cys Lys Leu Val Thr Asp Glu 
65                  70                  75                  80  


Cys Arg Lys Lys Leu Leu Gln Leu Lys Glu Lys Tyr Tyr Ala Ile Glu 
                85                  90                  95      


Val Asp Pro Val Leu Thr Val Glu Glu Lys Tyr Pro Tyr Met Val Glu 
            100                 105                 110         


Trp Tyr Thr Lys Ser His Gly Leu Leu Val Gln Gln Ala Leu Pro Lys 
        115                 120                 125             


Ala Lys Leu Lys Glu Ile Val Ala Glu Ser Asp Val Met Leu Lys Glu 
    130                 135                 140                 


Gly Tyr Glu Asn Phe Phe Asp Lys Leu Gln Gln His Ser Ile Pro Val 
145                 150                 155                 160 


Phe Ile Phe Ser Ala Gly Ile Gly Asp Val Leu Glu Glu Val Ile Arg 
                165                 170                 175     


Gln Ala Gly Val Tyr His Pro Asn Val Lys Val Val Ser Asn Phe Met 
            180                 185                 190         


Asp Phe Asp Glu Thr Gly Val Leu Lys Gly Phe Lys Gly Glu Leu Ile 
        195                 200                 205             


His Val Phe Asn Lys His Asp Gly Ala Leu Arg Asn Thr Glu Tyr Phe 
    210                 215                 220                 


Asn Gln Leu Lys Asp Asn Ser Asn Ile Ile Leu Leu Gly Asp Ser Gln 
225                 230                 235                 240 


Gly Asp Leu Arg Met Ala Asp Gly Val Ala Asn Val Glu His Ile Leu 
                245                 250                 255     


Lys Ile Gly Tyr Leu Asn Asp Arg Val Asp Glu Leu Leu Glu Lys Tyr 
            260                 265                 270         


Met Asp Ser Tyr Asp Ile Val Leu Val Gln Asp Glu Ser Leu Glu Val 
        275                 280                 285             


Ala Asn Ser Ile Leu Gln Lys Ile Leu 
    290                 295         


<210>  9599
<211>  297
<212>  PRT
<213>  Homo Sapiens

<400>  9599

Met Thr Asn Gln Glu Ser Ala Val His Val Lys Met Met Pro Glu Phe 
1               5                   10                  15      


Gln Lys Ser Ser Val Arg Ile Lys Asn Pro Thr Arg Val Glu Glu Ile 
            20                  25                  30          


Ile Cys Gly Leu Ile Lys Gly Gly Ala Ala Lys Leu Gln Ile Ile Thr 
        35                  40                  45              


Asp Phe Asp Met Thr Leu Ser Arg Phe Ser Tyr Lys Gly Lys Arg Cys 
    50                  55                  60                  


Pro Thr Cys His Asn Ile Ile Asp Asn Cys Lys Leu Val Thr Asp Glu 
65                  70                  75                  80  


Cys Arg Lys Lys Leu Leu Gln Leu Lys Glu Lys Tyr Tyr Ala Ile Glu 
                85                  90                  95      


Val Asp Pro Val Leu Thr Val Glu Glu Lys Tyr Pro Tyr Met Val Glu 
            100                 105                 110         


Trp Tyr Thr Lys Ser His Gly Leu Leu Val Gln Gln Ala Leu Pro Lys 
        115                 120                 125             


Ala Lys Leu Lys Glu Ile Val Ala Glu Ser Asp Val Met Leu Lys Glu 
    130                 135                 140                 


Gly Tyr Glu Asn Phe Phe Asp Lys Leu Gln Gln His Ser Ile Pro Val 
145                 150                 155                 160 


Phe Ile Phe Ser Ala Gly Ile Gly Asp Val Leu Glu Glu Val Ile Arg 
                165                 170                 175     


Gln Ala Gly Val Tyr His Pro Asn Val Lys Val Val Ser Asn Phe Met 
            180                 185                 190         


Asp Phe Asp Glu Thr Gly Val Leu Lys Gly Phe Lys Gly Glu Leu Ile 
        195                 200                 205             


His Val Phe Asn Lys His Asp Gly Ala Leu Arg Asn Thr Glu Tyr Phe 
    210                 215                 220                 


Asn Gln Leu Lys Asp Asn Ser Asn Ile Ile Leu Leu Gly Asp Ser Gln 
225                 230                 235                 240 


Gly Asp Leu Arg Met Ala Asp Gly Val Ala Asn Val Glu His Ile Leu 
                245                 250                 255     


Lys Ile Gly Tyr Leu Asn Asp Arg Val Asp Glu Leu Leu Glu Lys Tyr 
            260                 265                 270         


Met Asp Ser Tyr Asp Ile Val Leu Val Gln Asp Glu Ser Leu Glu Val 
        275                 280                 285             


Ala Asn Ser Ile Leu Gln Lys Ile Leu 
    290                 295         


<210>  9600
<211>  297
<212>  PRT
<213>  Homo Sapiens

<400>  9600

Met Thr Asn Gln Glu Ser Ala Val His Val Lys Met Met Pro Glu Phe 
1               5                   10                  15      


Gln Lys Ser Ser Val Arg Ile Lys Asn Pro Thr Arg Val Glu Glu Ile 
            20                  25                  30          


Ile Cys Gly Leu Ile Lys Gly Gly Ala Ala Lys Leu Gln Ile Ile Thr 
        35                  40                  45              


Asp Phe Asp Met Thr Leu Ser Arg Phe Ser Tyr Lys Gly Lys Arg Cys 
    50                  55                  60                  


Pro Thr Cys His Asn Ile Ile Asp Asn Cys Lys Leu Val Thr Asp Glu 
65                  70                  75                  80  


Cys Arg Lys Lys Leu Leu Gln Leu Lys Glu Lys Tyr Tyr Ala Ile Glu 
                85                  90                  95      


Val Asp Pro Val Leu Thr Val Glu Glu Lys Tyr Pro Tyr Met Val Glu 
            100                 105                 110         


Trp Tyr Thr Lys Ser His Gly Leu Leu Val Gln Gln Ala Leu Pro Lys 
        115                 120                 125             


Ala Lys Leu Lys Glu Ile Val Ala Glu Ser Asp Val Met Leu Lys Glu 
    130                 135                 140                 


Gly Tyr Glu Asn Phe Phe Asp Lys Leu Gln Gln His Ser Ile Pro Val 
145                 150                 155                 160 


Phe Ile Phe Ser Ala Gly Ile Gly Asp Val Leu Glu Glu Val Ile Arg 
                165                 170                 175     


Gln Ala Gly Val Tyr His Pro Asn Val Lys Val Val Ser Asn Phe Met 
            180                 185                 190         


Asp Phe Asp Glu Thr Gly Val Leu Lys Gly Phe Lys Gly Glu Leu Ile 
        195                 200                 205             


His Val Phe Asn Lys His Asp Gly Ala Leu Arg Asn Thr Glu Tyr Phe 
    210                 215                 220                 


Asn Gln Leu Lys Asp Asn Ser Asn Ile Ile Leu Leu Gly Asp Ser Gln 
225                 230                 235                 240 


Gly Asp Leu Arg Met Ala Asp Gly Val Ala Asn Val Glu His Ile Leu 
                245                 250                 255     


Lys Ile Gly Tyr Leu Asn Asp Arg Val Asp Glu Leu Leu Glu Lys Tyr 
            260                 265                 270         


Met Asp Ser Tyr Asp Ile Val Leu Val Gln Asp Glu Ser Leu Glu Val 
        275                 280                 285             


Ala Asn Ser Ile Leu Gln Lys Ile Leu 
    290                 295         


<210>  9601
<211>  205
<212>  PRT
<213>  Homo Sapiens

<400>  9601

Met Thr Asn Gln Glu Ser Ala Val His Val Lys Met Met Pro Glu Phe 
1               5                   10                  15      


Gln Lys Ser Ser Val Arg Ile Lys Asn Pro Thr Arg Val Glu Glu Ile 
            20                  25                  30          


Ile Cys Gly Leu Ile Lys Gly Gly Ala Ala Lys Leu Gln Ile Ile Thr 
        35                  40                  45              


Asp Phe Asp Met Thr Leu Ser Arg Phe Ser Tyr Lys Gly Lys Arg Cys 
    50                  55                  60                  


Pro Thr Cys His Asn Ile Ile Asp Asn Cys Lys Leu Val Thr Asp Glu 
65                  70                  75                  80  


Cys Arg Lys Lys Leu Leu Gln Leu Lys Glu Lys Tyr Tyr Ala Ile Glu 
                85                  90                  95      


Val Asp Pro Val Leu Thr Val Glu Glu Lys Tyr Pro Tyr Met Val Glu 
            100                 105                 110         


Trp Tyr Thr Lys Ser His Gly Leu Leu Val Gln Gln Ala Leu Pro Lys 
        115                 120                 125             


Ala Lys Leu Lys Glu Ile Val Ala Glu Ser Asp Val Met Leu Lys Glu 
    130                 135                 140                 


Gly Tyr Glu Asn Phe Phe Asp Lys Leu Gln Gln His Ser Ile Pro Val 
145                 150                 155                 160 


Phe Ile Phe Ser Ala Gly Ile Gly Asp Val Leu Glu Glu Val Ile Arg 
                165                 170                 175     


Gln Ala Gly Val Tyr His Pro Asn Val Lys Val Val Ser Asn Phe Met 
            180                 185                 190         


Asp Phe Asp Glu Thr Val Arg Ile Ser Asn Arg Ser Ser 
        195                 200                 205 


<210>  9602
<211>  548
<212>  PRT
<213>  Homo Sapiens

<400>  9602

Met Thr Met Ala Ala Ala Ala Val Val Ala Arg Gly Ala Gly Ala Arg 
1               5                   10                  15      


Ala Ala Thr Ala Ala Ala Leu Arg Gly Gly Cys Gly Thr Ala Ala Arg 
            20                  25                  30          


Gly Arg Pro Cys Ala Gly Pro Ala Arg Pro Leu Cys Thr Ala Pro Gly 
        35                  40                  45              


Thr Ala Pro Asp Met Lys Arg Tyr Leu Trp Glu Arg Tyr Arg Glu Ala 
    50                  55                  60                  


Lys Arg Ser Thr Glu Glu Leu Val Pro Ser Ile Met Ser Asn Leu Leu 
65                  70                  75                  80  


Asn Pro Asp Ala Ile Phe Ser Asn Asn Glu Met Ser Leu Ser Asp Ile 
                85                  90                  95      


Glu Ile Tyr Gly Phe Asp Tyr Asp Tyr Thr Leu Val Phe Tyr Ser Lys 
            100                 105                 110         


His Leu His Thr Leu Ile Phe Asn Ala Ala Arg Asp Leu Leu Ile Asn 
        115                 120                 125             


Glu His Arg Tyr Pro Ala Glu Ile Arg Lys Tyr Glu Tyr Asp Pro Asn 
    130                 135                 140                 


Phe Ala Ile Arg Gly Leu His Tyr Asp Val Gln Arg Ala Val Leu Met 
145                 150                 155                 160 


Lys Ile Asp Ala Phe His Tyr Ile Gln Leu Gly Thr Val Tyr Arg Gly 
                165                 170                 175     


Leu Ser Val Val Pro Asp Glu Glu Val Ile Glu Met Tyr Glu Gly Ser 
            180                 185                 190         


His Val Pro Leu Glu Gln Met Ser Asp Phe Tyr Gly Lys Ser Ser His 
        195                 200                 205             


Gly Asn Thr Met Lys Gln Phe Met Asp Ile Phe Ser Leu Pro Glu Met 
    210                 215                 220                 


Thr Leu Leu Ser Cys Val Asn Glu Tyr Phe Leu Lys Asn Asn Ile Asp 
225                 230                 235                 240 


Tyr Glu Pro Val His Leu Tyr Lys Asp Val Lys Asp Ser Ile Arg Asp 
                245                 250                 255     


Val His Ile Lys Gly Ile Met Tyr Arg Ala Ile Glu Ala Asp Ile Glu 
            260                 265                 270         


Lys Tyr Ile Cys Tyr Ala Glu Gln Thr Arg Ala Val Leu Ala Lys Leu 
        275                 280                 285             


Ala Asp His Gly Lys Lys Met Phe Leu Ile Thr Asn Ser Pro Ser Ser 
    290                 295                 300                 


Phe Val Asp Lys Gly Met Ser Tyr Ile Val Gly Lys Asp Trp Arg Asp 
305                 310                 315                 320 


Leu Phe Asp Val Val Ile Val Gln Ala Glu Lys Pro Asn Phe Phe Asn 
                325                 330                 335     


Asp Lys Arg Arg Pro Phe Arg Lys Met Asn Glu Lys Gly Val Leu Leu 
            340                 345                 350         


Trp Asp Lys Ile His Lys Leu Gln Lys Gly Gln Ile Tyr Lys Gln Gly 
        355                 360                 365             


Asn Leu Tyr Glu Phe Leu Lys Leu Thr Gly Trp Arg Gly Ser Arg Val 
    370                 375                 380                 


Leu Tyr Phe Gly Asp His Ile Tyr Ser Asp Leu Ala Asp Leu Thr Leu 
385                 390                 395                 400 


Lys His Gly Trp Arg Thr Gly Ala Ile Ile Pro Glu Leu Arg Ser Glu 
                405                 410                 415     


Leu Lys Ile Met Asn Thr Glu Gln Tyr Ile Gln Thr Met Thr Trp Leu 
            420                 425                 430         


Gln Thr Leu Thr Gly Leu Leu Glu Gln Met Gln Val His Arg Asp Ala 
        435                 440                 445             


Glu Ser Gln Leu Val Leu Gln Glu Trp Lys Lys Glu Arg Lys Glu Met 
    450                 455                 460                 


Arg Glu Met Thr Lys Ser Phe Phe Asn Ala Gln Phe Gly Ser Leu Phe 
465                 470                 475                 480 


Arg Thr Asp Gln Asn Pro Thr Tyr Phe Leu Arg Arg Leu Ser Arg Phe 
                485                 490                 495     


Ala Asp Ile Tyr Met Ala Ser Leu Ser Cys Leu Leu Asn Tyr Asp Val 
            500                 505                 510         


Ser His Thr Phe Tyr Pro Arg Arg Thr Pro Leu Gln His Glu Leu Pro 
        515                 520                 525             


Ala Trp Ser Glu Arg Pro Pro Thr Phe Gly Thr Pro Leu Leu Gln Glu 
    530                 535                 540                 


Ala Gln Ala Lys 
545             


<210>  9603
<211>  135
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9603

Xaa Ala Lys Leu Ala Asp His Gly Lys Lys Met Phe Leu Ile Thr Asn 
1               5                   10                  15      


Ser Pro Ser Ser Phe Val Asp Lys Gly Met Ser Tyr Ile Val Gly Lys 
            20                  25                  30          


Asp Trp Arg Asp Leu Phe Asp Val Val Ile Val Gln Ala Glu Lys Pro 
        35                  40                  45              


Asn Phe Phe Asn Asp Lys Arg Arg Pro Phe Arg Lys Met Asn Glu Lys 
    50                  55                  60                  


Gly Val Leu Leu Trp Asp Lys Ile His Lys Leu Gln Lys Gly Gln Ile 
65                  70                  75                  80  


Tyr Lys Gln Gly Asn Leu Tyr Glu Phe Leu Lys Leu Thr Gly Trp Arg 
                85                  90                  95      


Gly Ser Arg Val Leu Tyr Phe Gly Asp His Ile Tyr Ser Asp Leu Ala 
            100                 105                 110         


Thr Met Val Asn Asp Ser Arg Pro Ser Val Ser Ala Gly Val Val Thr 
        115                 120                 125             


His Gly Asn Tyr Phe Gln Asn 
    130                 135 


<210>  9604
<211>  122
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9604

Xaa Thr Met Thr Trp Leu Gln Thr Leu Thr Gly Leu Leu Glu Gln Met 
1               5                   10                  15      


Gln Val His Arg Asp Ala Glu Ser Gln Leu Val Leu Gln Glu Trp Lys 
            20                  25                  30          


Lys Glu Arg Lys Glu Met Arg Glu Met Thr Lys Ser Phe Phe Asn Ala 
        35                  40                  45              


Gln Phe Gly Ser Leu Phe Arg Thr Asp Gln Asn Pro Thr Tyr Phe Leu 
    50                  55                  60                  


Arg Arg Leu Ser Arg Phe Ala Asp Ile Tyr Met Ala Ser Leu Ser Cys 
65                  70                  75                  80  


Leu Leu Asn Tyr Asp Val Ser His Thr Phe Tyr Pro Arg Arg Thr Pro 
                85                  90                  95      


Leu Gln His Glu Leu Pro Ala Trp Ser Glu Arg Pro Pro Thr Phe Gly 
            100                 105                 110         


Thr Pro Leu Leu Gln Glu Ala Gln Ala Lys 
        115                 120         


<210>  9605
<211>  264
<212>  PRT
<213>  Homo Sapiens

<400>  9605

Met Cys Pro Arg Ala Ala Arg Ala Pro Ala Thr Leu Leu Leu Ala Leu 
1               5                   10                  15      


Gly Ala Val Leu Trp Pro Ala Ala Gly Ala Trp Glu Leu Thr Ile Leu 
            20                  25                  30          


His Thr Asn Asp Val His Ser Arg Leu Glu Gln Thr Ser Glu Asp Ser 
        35                  40                  45              


Ser Lys Cys Val Asn Ala Ser Arg Cys Met Gly Gly Val Ala Arg Leu 
    50                  55                  60                  


Phe Thr Lys Val Gln Gln Ile Arg Arg Ala Glu Pro Asn Val Leu Leu 
65                  70                  75                  80  


Leu Asp Ala Gly Asp Gln Tyr Gln Gly Thr Ile Trp Phe Thr Val Tyr 
                85                  90                  95      


Lys Gly Ala Glu Val Ala His Phe Met Asn Ala Leu Arg Tyr Asp Ala 
            100                 105                 110         


Met Ala Leu Gly Asn His Glu Phe Asp Asn Gly Val Glu Gly Leu Ile 
        115                 120                 125             


Glu Pro Leu Leu Lys Glu Ala Lys Phe Pro Ile Leu Ser Ala Asn Ile 
    130                 135                 140                 


Lys Ala Lys Gly Pro Leu Ala Ser Gln Ile Ser Gly Leu Tyr Leu Pro 
145                 150                 155                 160 


Tyr Lys Val Leu Pro Val Gly Asp Glu Val Val Gly Ile Val Gly Tyr 
                165                 170                 175     


Thr Ser Lys Glu Thr Pro Phe Leu Ser Asn Pro Gly Thr Asn Leu Val 
            180                 185                 190         


Phe Glu Asp Glu Ile Thr Ala Leu Gln Pro Glu Val Asp Lys Leu Lys 
        195                 200                 205             


Thr Leu Asn Val Asn Lys Ile Ile Ala Leu Gly His Ser Gly Phe Glu 
    210                 215                 220                 


Met Asp Lys Leu Ile Ala Gln Lys Val Arg Gly Val Asp Val Val Val 
225                 230                 235                 240 


Gly Gly His Ser Asn Thr Phe Leu Tyr Thr Gly Asn Cys Phe Lys Arg 
                245                 250                 255     


Ile Ala Trp Ala Arg Met Ser Arg 
            260                 


<210>  9606
<211>  574
<212>  PRT
<213>  Homo Sapiens

<400>  9606

Met Cys Pro Arg Ala Ala Arg Ala Pro Ala Thr Leu Leu Leu Ala Leu 
1               5                   10                  15      


Gly Ala Val Leu Trp Pro Ala Ala Gly Ala Trp Glu Leu Thr Ile Leu 
            20                  25                  30          


His Thr Asn Asp Val His Ser Arg Leu Glu Gln Thr Ser Glu Asp Ser 
        35                  40                  45              


Ser Lys Cys Val Asn Ala Ser Arg Cys Met Gly Gly Val Ala Arg Leu 
    50                  55                  60                  


Phe Thr Lys Val Gln Gln Ile Arg Arg Ala Glu Pro Asn Val Leu Leu 
65                  70                  75                  80  


Leu Asp Ala Gly Asp Gln Tyr Gln Gly Thr Ile Trp Phe Thr Val Tyr 
                85                  90                  95      


Lys Gly Ala Glu Val Ala His Phe Met Asn Ala Leu Arg Tyr Asp Ala 
            100                 105                 110         


Met Ala Leu Gly Asn His Glu Phe Asp Asn Gly Val Glu Gly Leu Ile 
        115                 120                 125             


Glu Pro Leu Leu Lys Glu Ala Lys Phe Pro Ile Leu Ser Ala Asn Ile 
    130                 135                 140                 


Lys Ala Lys Gly Pro Leu Ala Ser Gln Ile Ser Gly Leu Tyr Leu Pro 
145                 150                 155                 160 


Tyr Lys Val Leu Pro Val Gly Asp Glu Val Val Gly Ile Val Gly Tyr 
                165                 170                 175     


Thr Ser Lys Glu Thr Pro Phe Leu Ser Asn Pro Gly Thr Asn Leu Val 
            180                 185                 190         


Phe Glu Asp Glu Ile Thr Ala Leu Gln Pro Glu Val Asp Lys Leu Lys 
        195                 200                 205             


Thr Leu Asn Val Asn Lys Ile Ile Ala Leu Gly His Ser Gly Phe Glu 
    210                 215                 220                 


Met Asp Lys Leu Ile Ala Gln Lys Val Arg Gly Val Asp Val Val Val 
225                 230                 235                 240 


Gly Gly His Ser Asn Thr Phe Leu Tyr Thr Gly Asn Pro Pro Ser Lys 
                245                 250                 255     


Glu Val Pro Ala Gly Lys Tyr Pro Phe Ile Val Thr Ser Asp Asp Gly 
            260                 265                 270         


Arg Lys Val Pro Val Val Gln Ala Tyr Ala Phe Gly Lys Tyr Leu Gly 
        275                 280                 285             


Tyr Leu Lys Ile Glu Phe Asp Glu Arg Gly Asn Val Ile Ser Ser His 
    290                 295                 300                 


Gly Asn Pro Ile Leu Leu Asn Ser Ser Ile Pro Glu Asp Pro Ser Ile 
305                 310                 315                 320 


Lys Ala Asp Ile Asn Lys Trp Arg Ile Lys Leu Asp Asn Tyr Ser Thr 
                325                 330                 335     


Gln Glu Leu Gly Lys Thr Ile Val Tyr Leu Asp Gly Ser Ser Gln Ser 
            340                 345                 350         


Cys Arg Phe Arg Glu Cys Asn Met Gly Asn Leu Ile Cys Asp Ala Met 
        355                 360                 365             


Ile Asn Asn Asn Leu Arg His Thr Asp Glu Met Phe Trp Asn His Val 
    370                 375                 380                 


Ser Met Cys Ile Leu Asn Gly Gly Gly Ile Arg Ser Pro Ile Asp Glu 
385                 390                 395                 400 


Arg Asn Asn Gly Thr Ile Thr Trp Glu Asn Leu Ala Ala Val Leu Pro 
                405                 410                 415     


Phe Gly Gly Thr Phe Asp Leu Val Gln Leu Lys Gly Ser Thr Leu Lys 
            420                 425                 430         


Lys Ala Phe Glu His Ser Val His Arg Tyr Gly Gln Ser Thr Gly Glu 
        435                 440                 445             


Phe Leu Gln Val Gly Gly Ile His Val Val Tyr Asp Leu Ser Arg Lys 
    450                 455                 460                 


Pro Gly Asp Arg Val Val Lys Leu Asp Val Leu Cys Thr Lys Cys Arg 
465                 470                 475                 480 


Val Pro Ser Tyr Asp Pro Leu Lys Met Asp Glu Val Tyr Lys Val Ile 
                485                 490                 495     


Leu Pro Asn Phe Leu Ala Asn Gly Gly Asp Gly Phe Gln Met Ile Lys 
            500                 505                 510         


Asp Glu Leu Leu Arg His Asp Ser Gly Asp Gln Asp Ile Asn Val Val 
        515                 520                 525             


Ser Thr Tyr Ile Ser Lys Met Lys Val Ile Tyr Pro Ala Val Glu Gly 
    530                 535                 540                 


Arg Ile Lys Phe Ser Thr Gly Ser His Cys His Gly Ser Phe Ser Leu 
545                 550                 555                 560 


Ile Phe Leu Ser Leu Trp Ala Val Ile Phe Val Leu Tyr Gln 
                565                 570                 


<210>  9607
<211>  524
<212>  PRT
<213>  Homo Sapiens

<400>  9607

Met Cys Pro Arg Ala Ala Arg Ala Pro Ala Thr Leu Leu Leu Ala Leu 
1               5                   10                  15      


Gly Ala Val Leu Trp Pro Ala Ala Gly Ala Trp Glu Leu Thr Ile Leu 
            20                  25                  30          


His Thr Asn Asp Val His Ser Arg Leu Glu Gln Thr Ser Glu Asp Ser 
        35                  40                  45              


Ser Lys Cys Val Asn Ala Ser Arg Cys Met Gly Gly Val Ala Arg Leu 
    50                  55                  60                  


Phe Thr Lys Val Gln Gln Ile Arg Arg Ala Glu Pro Asn Val Leu Leu 
65                  70                  75                  80  


Leu Asp Ala Gly Asp Gln Tyr Gln Gly Thr Ile Trp Phe Thr Val Tyr 
                85                  90                  95      


Lys Gly Ala Glu Val Ala His Phe Met Asn Ala Leu Arg Tyr Asp Ala 
            100                 105                 110         


Met Ala Leu Gly Asn His Glu Phe Asp Asn Gly Val Glu Gly Leu Ile 
        115                 120                 125             


Glu Pro Leu Leu Lys Glu Ala Lys Phe Pro Ile Leu Ser Ala Asn Ile 
    130                 135                 140                 


Lys Ala Lys Gly Pro Leu Ala Ser Gln Ile Ser Gly Leu Tyr Leu Pro 
145                 150                 155                 160 


Tyr Lys Val Leu Pro Val Gly Asp Glu Val Val Gly Ile Val Gly Tyr 
                165                 170                 175     


Thr Ser Lys Glu Thr Pro Phe Leu Ser Asn Pro Gly Thr Asn Leu Val 
            180                 185                 190         


Phe Glu Asp Glu Ile Thr Ala Leu Gln Pro Glu Val Asp Lys Leu Lys 
        195                 200                 205             


Thr Leu Asn Val Asn Lys Ile Ile Ala Leu Gly His Ser Gly Phe Glu 
    210                 215                 220                 


Met Asp Lys Leu Ile Ala Gln Lys Val Arg Gly Val Asp Val Val Val 
225                 230                 235                 240 


Gly Gly His Ser Asn Thr Phe Leu Tyr Thr Gly Asn Pro Pro Ser Lys 
                245                 250                 255     


Glu Val Pro Ala Gly Lys Tyr Pro Phe Ile Val Thr Ser Asp Asp Gly 
            260                 265                 270         


Arg Lys Val Pro Val Val Gln Ala Tyr Ala Phe Gly Lys Tyr Leu Gly 
        275                 280                 285             


Tyr Leu Lys Ile Glu Phe Asp Glu Arg Gly Asn Val Ile Ser Ser His 
    290                 295                 300                 


Gly Asn Pro Ile Leu Leu Asn Ser Ser Ile Pro Glu Asp Pro Ser Ile 
305                 310                 315                 320 


Lys Ala Asp Ile Asn Lys Trp Arg Ile Lys Leu Asp Asn Tyr Ser Thr 
                325                 330                 335     


Gln Glu Leu Gly Lys Thr Ile Val Tyr Leu Asp Gly Ser Ser Gln Ser 
            340                 345                 350         


Cys Arg Phe Arg Glu Cys Asn Met Gly Asn Leu Ile Cys Asp Ala Met 
        355                 360                 365             


Ile Asn Asn Asn Leu Arg His Thr Asp Glu Met Phe Trp Asn His Val 
    370                 375                 380                 


Ser Met Cys Ile Leu Asn Gly Gly Gly Ile Arg Ser Pro Ile Asp Glu 
385                 390                 395                 400 


Arg Asn Asn Gly Ile His Val Val Tyr Asp Leu Ser Arg Lys Pro Gly 
                405                 410                 415     


Asp Arg Val Val Lys Leu Asp Val Leu Cys Thr Lys Cys Arg Val Pro 
            420                 425                 430         


Ser Tyr Asp Pro Leu Lys Met Asp Glu Val Tyr Lys Val Ile Leu Pro 
        435                 440                 445             


Asn Phe Leu Ala Asn Gly Gly Asp Gly Phe Gln Met Ile Lys Asp Glu 
    450                 455                 460                 


Leu Leu Arg His Asp Ser Gly Asp Gln Asp Ile Asn Val Val Ser Thr 
465                 470                 475                 480 


Tyr Ile Ser Lys Met Lys Val Ile Tyr Pro Ala Val Glu Gly Arg Ile 
                485                 490                 495     


Lys Phe Ser Thr Gly Ser His Cys His Gly Ser Phe Ser Leu Ile Phe 
            500                 505                 510         


Leu Ser Leu Trp Ala Val Ile Phe Val Leu Tyr Gln 
        515                 520                 


<210>  9608
<211>  230
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9608

Xaa Asp Val Val Val Gly Gly His Ser Asn Thr Phe Leu Tyr Thr Gly 
1               5                   10                  15      


Asn Pro Pro Ser Lys Glu Val Pro Ala Gly Lys Tyr Pro Phe Ile Val 
            20                  25                  30          


Thr Ser Asp Asp Gly Arg Lys Val Pro Val Val Gln Ala Tyr Ala Phe 
        35                  40                  45              


Gly Lys Tyr Leu Gly Tyr Leu Lys Ile Glu Phe Asp Glu Arg Gly Asn 
    50                  55                  60                  


Val Ile Ser Ser His Gly Asn Pro Ile Leu Leu Asn Ser Ser Ile Pro 
65                  70                  75                  80  


Glu Asp Pro Ser Ile Lys Ala Asp Ile Asn Lys Trp Arg Ile Lys Leu 
                85                  90                  95      


Asp Asn Tyr Ser Thr Gln Glu Leu Gly Lys Thr Ile Val Tyr Leu Asp 
            100                 105                 110         


Gly Ser Ser Gln Ser Cys Arg Phe Arg Glu Cys Asn Met Gly Asn Leu 
        115                 120                 125             


Ile Cys Asp Ala Met Ile Asn Asn Asn Leu Arg His Thr Asp Glu Met 
    130                 135                 140                 


Phe Trp Asn His Val Ser Met Cys Ile Leu Asn Gly Gly Gly Ile Arg 
145                 150                 155                 160 


Ser Pro Ile Asp Glu Arg Asn Asn Gly Ile His Val Val Tyr Asp Leu 
                165                 170                 175     


Ser Arg Lys Pro Gly Asp Arg Val Val Lys Leu Asp Val Leu Cys Thr 
            180                 185                 190         


Lys Cys Arg Val Pro Ser Tyr Asp Pro Leu Lys Met Asp Glu Val Tyr 
        195                 200                 205             


Lys Val Ile Leu Pro Asn Phe Leu Ala Asn Gly Gly Asp Gly Phe Gln 
    210                 215                 220                 


Met Ile Lys Asp Glu Leu 
225                 230 


<210>  9609
<211>  179
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9609

Xaa Asn Pro Ile Leu Leu Asn Ser Ser Ile Pro Glu Asp Pro Ser Ile 
1               5                   10                  15      


Lys Ala Asp Ile Asn Lys Trp Arg Ile Lys Leu Asp Asn Tyr Ser Thr 
            20                  25                  30          


Gln Glu Leu Gly Lys Thr Ile Val Tyr Leu Asp Gly Ser Ser Gln Ser 
        35                  40                  45              


Cys Arg Phe Arg Glu Cys Asn Met Gly Asn Leu Ile Cys Asp Ala Met 
    50                  55                  60                  


Ile Asn Asn Asn Leu Arg His Thr Asp Glu Met Phe Trp Asn His Val 
65                  70                  75                  80  


Ser Met Cys Ile Leu Asn Gly Gly Gly Ile Arg Ser Pro Ile Asp Glu 
                85                  90                  95      


Arg Asn Asn Gly Thr Ile Thr Trp Glu Asn Leu Ala Ala Val Leu Pro 
            100                 105                 110         


Phe Gly Gly Thr Phe Asp Leu Val Gln Leu Lys Gly Ser Thr Leu Lys 
        115                 120                 125             


Lys Ala Phe Glu His Ser Val His Arg Tyr Gly Gln Ser Thr Gly Glu 
    130                 135                 140                 


Phe Leu Gln Val Gly Asp Leu Lys Glu Cys Cys Pro Ile Cys Ile Asn 
145                 150                 155                 160 


Gln Asp Asp Ser Trp Lys Glu Gln Pro Thr Ala Gln Thr Tyr Leu Asn 
                165                 170                 175     


Thr Trp Phe 
            


<210>  9610
<211>  257
<212>  PRT
<213>  Homo Sapiens

<400>  9610

Met Ser Ile Leu Phe Tyr Val Ile Phe Leu Ala Tyr Leu Arg Gly Ile 
1               5                   10                  15      


Gln Gly Asn Asn Met Asp Gln Arg Ser Leu Pro Glu Asp Ser Leu Asn 
            20                  25                  30          


Ser Leu Ile Ile Lys Leu Ile Gln Ala Asp Ile Leu Lys Asn Lys Leu 
        35                  40                  45              


Ser Lys Gln Met Val Asp Val Lys Glu Asn Tyr Gln Ser Thr Leu Pro 
    50                  55                  60                  


Lys Ala Glu Ala Pro Arg Glu Pro Glu Arg Gly Gly Pro Ala Lys Ser 
65                  70                  75                  80  


Ala Phe Gln Pro Val Ile Ala Met Asp Thr Glu Leu Leu Arg Gln Gln 
                85                  90                  95      


Arg Arg Tyr Asn Ser Pro Arg Val Leu Leu Ser Asp Ser Thr Pro Leu 
            100                 105                 110         


Glu Pro Pro Pro Leu Tyr Leu Met Glu Asp Tyr Val Gly Ser Pro Val 
        115                 120                 125             


Val Ala Asn Arg Thr Ser Arg Arg Lys Arg Tyr Ala Glu His Lys Ser 
    130                 135                 140                 


His Arg Gly Glu Tyr Ser Val Cys Asp Ser Glu Ser Leu Trp Val Thr 
145                 150                 155                 160 


Asp Lys Ser Ser Ala Ile Asp Ile Arg Gly His Gln Val Thr Val Leu 
                165                 170                 175     


Gly Glu Ile Lys Thr Gly Asn Ser Pro Val Lys Gln Tyr Phe Tyr Glu 
            180                 185                 190         


Thr Arg Cys Lys Glu Ala Arg Pro Val Lys Asn Gly Cys Arg Gly Ile 
        195                 200                 205             


Asp Asp Lys His Trp Asn Ser Gln Cys Lys Thr Ser Gln Thr Tyr Val 
    210                 215                 220                 


Arg Ala Leu Thr Ser Glu Asn Asn Lys Leu Val Gly Trp Arg Trp Ile 
225                 230                 235                 240 


Arg Ile Asp Thr Ser Cys Val Cys Ala Leu Ser Arg Lys Ile Gly Arg 
                245                 250                 255     


Thr 
    


<210>  9611
<211>  270
<212>  PRT
<213>  Homo Sapiens

<400>  9611

Met Val Thr Phe Ala Thr Ile Leu Gln Val Asn Lys Val Met Ser Ile 
1               5                   10                  15      


Leu Phe Tyr Val Ile Phe Leu Ala Tyr Leu Arg Gly Ile Gln Gly Asn 
            20                  25                  30          


Asn Met Asp Gln Arg Ser Leu Pro Glu Asp Ser Leu Asn Ser Leu Ile 
        35                  40                  45              


Ile Lys Leu Ile Gln Ala Asp Ile Leu Lys Asn Lys Leu Ser Lys Gln 
    50                  55                  60                  


Met Val Asp Val Lys Glu Asn Tyr Gln Ser Thr Leu Pro Lys Ala Glu 
65                  70                  75                  80  


Ala Pro Arg Glu Pro Glu Arg Gly Gly Pro Ala Lys Ser Ala Phe Gln 
                85                  90                  95      


Pro Val Ile Ala Met Asp Thr Glu Leu Leu Arg Gln Gln Arg Arg Tyr 
            100                 105                 110         


Asn Ser Pro Arg Val Leu Leu Ser Asp Ser Thr Pro Leu Glu Pro Pro 
        115                 120                 125             


Pro Leu Tyr Leu Met Glu Asp Tyr Val Gly Ser Pro Val Val Ala Asn 
    130                 135                 140                 


Arg Thr Ser Arg Arg Lys Arg Tyr Ala Glu His Lys Ser His Arg Gly 
145                 150                 155                 160 


Glu Tyr Ser Val Cys Asp Ser Glu Ser Leu Trp Val Thr Asp Lys Ser 
                165                 170                 175     


Ser Ala Ile Asp Ile Arg Gly His Gln Val Thr Val Leu Gly Glu Ile 
            180                 185                 190         


Lys Thr Gly Asn Ser Pro Val Lys Gln Tyr Phe Tyr Glu Thr Arg Cys 
        195                 200                 205             


Lys Glu Ala Arg Pro Val Lys Asn Gly Cys Arg Gly Ile Asp Asp Lys 
    210                 215                 220                 


His Trp Asn Ser Gln Cys Lys Thr Ser Gln Thr Tyr Val Arg Ala Leu 
225                 230                 235                 240 


Thr Ser Glu Asn Asn Lys Leu Val Gly Trp Arg Trp Ile Arg Ile Asp 
                245                 250                 255     


Thr Ser Cys Val Cys Ala Leu Ser Arg Lys Ile Gly Arg Thr 
            260                 265                 270 


<210>  9612
<211>  143
<212>  PRT
<213>  Homo Sapiens

<400>  9612

Met Leu Pro Leu Pro Ser Cys Ser Leu Pro Ile Leu Leu Leu Phe Leu 
1               5                   10                  15      


Leu Pro Ser Val Pro Ile Glu Ser Gln Pro Pro Pro Ser Thr Leu Pro 
            20                  25                  30          


Pro Phe Leu Ala Pro Glu Trp Asp Leu Leu Ser Pro Arg Val Val Leu 
        35                  40                  45              


Ser Arg Gly Ala Pro Ala Gly Pro Pro Leu Leu Phe Leu Leu Glu Ala 
    50                  55                  60                  


Gly Ala Phe Arg Glu Ser Ala Gly Ala Pro Ala Asn Arg Ser Arg Arg 
65                  70                  75                  80  


Gly Val Ser Glu Thr Ala Pro Ala Ser Arg Arg Gly Glu Leu Ala Val 
                85                  90                  95      


Cys Asp Ala Val Ser Gly Trp Val Thr Asp Arg Arg Thr Ala Val Asp 
            100                 105                 110         


Leu Arg Gly Arg Glu Val Glu Val Leu Gly Glu Val Pro Ala Ala Gly 
        115                 120                 125             


Gly Ser Pro Leu Arg Gln Tyr Phe Phe Glu Thr Arg Cys Lys Ala 
    130                 135                 140             


<210>  9613
<211>  210
<212>  PRT
<213>  Homo Sapiens

<400>  9613

Met Leu Pro Leu Pro Ser Cys Ser Leu Pro Ile Leu Leu Leu Phe Leu 
1               5                   10                  15      


Leu Pro Ser Val Pro Ile Glu Ser Gln Pro Pro Pro Ser Thr Leu Pro 
            20                  25                  30          


Pro Phe Leu Ala Pro Glu Trp Asp Leu Leu Ser Pro Arg Val Val Leu 
        35                  40                  45              


Ser Arg Gly Ala Pro Ala Gly Pro Pro Leu Leu Phe Leu Leu Glu Ala 
    50                  55                  60                  


Gly Ala Phe Arg Glu Ser Ala Gly Ala Pro Ala Asn Arg Ser Arg Arg 
65                  70                  75                  80  


Gly Val Ser Glu Thr Ala Pro Ala Ser Arg Arg Gly Glu Leu Ala Val 
                85                  90                  95      


Cys Asp Ala Val Ser Gly Trp Val Thr Asp Arg Arg Thr Ala Val Asp 
            100                 105                 110         


Leu Arg Gly Arg Glu Val Glu Val Leu Gly Glu Val Pro Ala Ala Gly 
        115                 120                 125             


Gly Ser Pro Leu Arg Gln Tyr Phe Phe Glu Thr Arg Cys Lys Ala Asp 
    130                 135                 140                 


Asn Ala Glu Glu Gly Gly Pro Gly Ala Gly Gly Gly Gly Cys Arg Gly 
145                 150                 155                 160 


Val Asp Arg Arg His Trp Val Ser Glu Cys Lys Ala Lys Gln Ser Tyr 
                165                 170                 175     


Val Arg Ala Leu Thr Ala Asp Ala Gln Gly Arg Val Gly Trp Arg Trp 
            180                 185                 190         


Ile Arg Ile Asp Thr Ala Cys Val Cys Thr Leu Leu Ser Arg Thr Gly 
        195                 200                 205             


Arg Ala 
    210 


<210>  9614
<211>  316
<212>  PRT
<213>  Homo Sapiens

<400>  9614

Met Gly Val Cys Gly Tyr Leu Phe Leu Pro Trp Lys Cys Leu Val Val 
1               5                   10                  15      


Val Ser Leu Arg Leu Leu Phe Leu Val Pro Thr Gly Val Pro Val Arg 
            20                  25                  30          


Ser Gly Asp Ala Thr Phe Pro Lys Ala Met Asp Asn Val Thr Val Arg 
        35                  40                  45              


Gln Gly Glu Ser Ala Thr Leu Arg Cys Thr Ile Asp Asn Arg Val Thr 
    50                  55                  60                  


Arg Val Ala Trp Leu Asn Arg Ser Thr Ile Leu Tyr Ala Gly Asn Asp 
65                  70                  75                  80  


Lys Trp Cys Leu Asp Pro Arg Val Val Leu Leu Ser Asn Thr Gln Thr 
                85                  90                  95      


Gln Tyr Ser Ile Glu Ile Gln Asn Val Asp Val Tyr Asp Glu Gly Pro 
            100                 105                 110         


Tyr Thr Cys Ser Val Gln Thr Asp Asn His Pro Lys Thr Ser Arg Val 
        115                 120                 125             


His Leu Ile Val Gln Val Ser Pro Lys Ile Val Glu Ile Ser Ser Asp 
    130                 135                 140                 


Ile Ser Ile Asn Glu Gly Asn Asn Ile Ser Leu Thr Cys Ile Ala Thr 
145                 150                 155                 160 


Gly Arg Pro Glu Pro Thr Val Thr Trp Arg His Ile Ser Pro Lys Ala 
                165                 170                 175     


Val Gly Phe Val Ser Glu Asp Glu Tyr Leu Glu Ile Gln Gly Ile Thr 
            180                 185                 190         


Arg Glu Gln Ser Gly Asp Tyr Glu Cys Ser Ala Ser Asn Asp Val Ala 
        195                 200                 205             


Ala Pro Val Val Arg Arg Val Lys Val Thr Val Asn Tyr Pro Pro Tyr 
    210                 215                 220                 


Ile Ser Glu Ala Lys Gly Thr Gly Val Pro Val Gly Gln Lys Gly Thr 
225                 230                 235                 240 


Leu Gln Cys Glu Ala Ser Ala Val Pro Ser Ala Glu Phe Gln Trp Tyr 
                245                 250                 255     


Lys Asp Asp Lys Arg Leu Ile Glu Gly Lys Lys Gly Val Lys Val Glu 
            260                 265                 270         


Asn Arg Pro Phe Leu Ser Lys Leu Ile Phe Phe Asn Val Ser Glu His 
        275                 280                 285             


Asp Tyr Gly Asn Tyr Thr Cys Val Ala Ser Asn Lys Leu Gly His Thr 
    290                 295                 300                 


Asn Ala Ser Ile Met Leu Phe Gly Glu Thr Val Leu 
305                 310                 315     


<210>  9615
<211>  344
<212>  PRT
<213>  Homo Sapiens

<400>  9615

Met Gly Val Cys Gly Tyr Leu Phe Leu Pro Trp Lys Cys Leu Val Val 
1               5                   10                  15      


Val Ser Leu Arg Leu Leu Phe Leu Val Pro Thr Gly Val Pro Val Arg 
            20                  25                  30          


Ser Gly Asp Ala Thr Phe Pro Lys Ala Met Asp Asn Val Thr Val Arg 
        35                  40                  45              


Gln Gly Glu Ser Ala Thr Leu Arg Cys Thr Ile Asp Asn Arg Val Thr 
    50                  55                  60                  


Arg Val Ala Trp Leu Asn Arg Ser Thr Ile Leu Tyr Ala Gly Asn Asp 
65                  70                  75                  80  


Lys Trp Cys Leu Asp Pro Arg Val Val Leu Leu Ser Asn Thr Gln Thr 
                85                  90                  95      


Gln Tyr Ser Ile Glu Ile Gln Asn Val Asp Val Tyr Asp Glu Gly Pro 
            100                 105                 110         


Tyr Thr Cys Ser Val Gln Thr Asp Asn His Pro Lys Thr Ser Arg Val 
        115                 120                 125             


His Leu Ile Val Gln Val Ser Pro Lys Ile Val Glu Ile Ser Ser Asp 
    130                 135                 140                 


Ile Ser Ile Asn Glu Gly Asn Asn Ile Ser Leu Thr Cys Ile Ala Thr 
145                 150                 155                 160 


Gly Arg Pro Glu Pro Thr Val Thr Trp Arg His Ile Ser Pro Lys Ala 
                165                 170                 175     


Val Gly Phe Val Ser Glu Asp Glu Tyr Leu Glu Ile Gln Gly Ile Thr 
            180                 185                 190         


Arg Glu Gln Ser Gly Asp Tyr Glu Cys Ser Ala Ser Asn Asp Val Ala 
        195                 200                 205             


Ala Pro Val Val Arg Arg Val Lys Val Thr Val Asn Tyr Pro Pro Tyr 
    210                 215                 220                 


Ile Ser Glu Ala Lys Gly Thr Gly Val Pro Val Gly Gln Lys Gly Thr 
225                 230                 235                 240 


Leu Gln Cys Glu Ala Ser Ala Val Pro Ser Ala Glu Phe Gln Trp Tyr 
                245                 250                 255     


Lys Asp Asp Lys Arg Leu Ile Glu Gly Lys Lys Gly Val Lys Val Glu 
            260                 265                 270         


Asn Arg Pro Phe Leu Ser Lys Leu Ile Phe Phe Asn Val Ser Glu His 
        275                 280                 285             


Asp Tyr Gly Asn Tyr Thr Cys Val Ala Ser Asn Lys Leu Gly His Thr 
    290                 295                 300                 


Asn Ala Ser Ile Met Leu Phe Gly Pro Gly Ala Val Ser Glu Val Ser 
305                 310                 315                 320 


Asn Gly Thr Ser Arg Arg Ala Gly Cys Val Trp Leu Leu Pro Leu Leu 
                325                 330                 335     


Val Leu His Leu Leu Leu Lys Phe 
            340                 


<210>  9616
<211>  355
<212>  PRT
<213>  Homo Sapiens

<400>  9616

Met Gly Val Cys Gly Tyr Leu Phe Leu Pro Trp Lys Cys Leu Val Val 
1               5                   10                  15      


Val Ser Leu Arg Leu Leu Phe Leu Val Pro Thr Gly Val Pro Val Arg 
            20                  25                  30          


Ser Gly Asp Ala Thr Phe Pro Lys Ala Met Asp Asn Val Thr Val Arg 
        35                  40                  45              


Gln Gly Glu Ser Ala Thr Leu Arg Cys Thr Ile Asp Asn Arg Val Thr 
    50                  55                  60                  


Arg Val Ala Trp Leu Asn Arg Ser Thr Ile Leu Tyr Ala Gly Asn Asp 
65                  70                  75                  80  


Lys Trp Cys Leu Asp Pro Arg Val Val Leu Leu Ser Asn Thr Gln Thr 
                85                  90                  95      


Gln Tyr Ser Ile Glu Ile Gln Asn Val Asp Val Tyr Asp Glu Gly Pro 
            100                 105                 110         


Tyr Thr Cys Ser Val Gln Thr Asp Asn His Pro Lys Thr Ser Arg Val 
        115                 120                 125             


His Leu Ile Val Gln Val Ser Pro Lys Ile Val Glu Ile Ser Ser Asp 
    130                 135                 140                 


Ile Ser Ile Asn Glu Gly Asn Asn Ile Ser Leu Thr Cys Ile Ala Thr 
145                 150                 155                 160 


Gly Arg Pro Glu Pro Thr Val Thr Trp Arg His Ile Ser Pro Lys Ala 
                165                 170                 175     


Val Gly Phe Val Ser Glu Asp Glu Tyr Leu Glu Ile Gln Gly Ile Thr 
            180                 185                 190         


Arg Glu Gln Ser Gly Asp Tyr Glu Cys Ser Ala Ser Asn Asp Val Ala 
        195                 200                 205             


Ala Pro Val Val Arg Arg Val Lys Val Thr Val Asn Tyr Pro Pro Tyr 
    210                 215                 220                 


Ile Ser Glu Ala Lys Gly Thr Gly Val Pro Val Gly Gln Lys Gly Thr 
225                 230                 235                 240 


Leu Gln Cys Glu Ala Ser Ala Val Pro Ser Ala Glu Phe Gln Trp Tyr 
                245                 250                 255     


Lys Asp Asp Lys Arg Leu Ile Glu Gly Lys Lys Gly Val Lys Val Glu 
            260                 265                 270         


Asn Arg Pro Phe Leu Ser Lys Leu Ile Phe Phe Asn Val Ser Glu His 
        275                 280                 285             


Asp Tyr Gly Asn Tyr Thr Cys Val Ala Ser Asn Lys Leu Gly His Thr 
    290                 295                 300                 


Asn Ala Ser Ile Met Leu Phe Glu Val Lys Thr Thr Ala Leu Thr Pro 
305                 310                 315                 320 


Trp Lys Gly Pro Gly Ala Val Ser Glu Val Ser Asn Gly Thr Ser Arg 
                325                 330                 335     


Arg Ala Gly Cys Val Trp Leu Leu Pro Leu Leu Val Leu His Leu Leu 
            340                 345                 350         


Leu Lys Phe 
        355 


<210>  9617
<211>  344
<212>  PRT
<213>  Homo Sapiens

<400>  9617

Met Lys Thr Ile Gln Pro Lys Met His Asn Ser Ile Ser Trp Ala Ile 
1               5                   10                  15      


Phe Thr Gly Leu Ala Ala Leu Cys Leu Phe Gln Gly Val Pro Val Arg 
            20                  25                  30          


Ser Gly Asp Ala Thr Phe Pro Lys Ala Met Asp Asn Val Thr Val Arg 
        35                  40                  45              


Gln Gly Glu Ser Ala Thr Leu Arg Cys Thr Ile Asp Asn Arg Val Thr 
    50                  55                  60                  


Arg Val Ala Trp Leu Asn Arg Ser Thr Ile Leu Tyr Ala Gly Asn Asp 
65                  70                  75                  80  


Lys Trp Cys Leu Asp Pro Arg Val Val Leu Leu Ser Asn Thr Gln Thr 
                85                  90                  95      


Gln Tyr Ser Ile Glu Ile Gln Asn Val Asp Val Tyr Asp Glu Gly Pro 
            100                 105                 110         


Tyr Thr Cys Ser Val Gln Thr Asp Asn His Pro Lys Thr Ser Arg Val 
        115                 120                 125             


His Leu Ile Val Gln Val Ser Pro Lys Ile Val Glu Ile Ser Ser Asp 
    130                 135                 140                 


Ile Ser Ile Asn Glu Gly Asn Asn Ile Ser Leu Thr Cys Ile Ala Thr 
145                 150                 155                 160 


Gly Arg Pro Glu Pro Thr Val Thr Trp Arg His Ile Ser Pro Lys Ala 
                165                 170                 175     


Val Gly Phe Val Ser Glu Asp Glu Tyr Leu Glu Ile Gln Gly Ile Thr 
            180                 185                 190         


Arg Glu Gln Ser Gly Asp Tyr Glu Cys Ser Ala Ser Asn Asp Val Ala 
        195                 200                 205             


Ala Pro Val Val Arg Arg Val Lys Val Thr Val Asn Tyr Pro Pro Tyr 
    210                 215                 220                 


Ile Ser Glu Ala Lys Gly Thr Gly Val Pro Val Gly Gln Lys Gly Thr 
225                 230                 235                 240 


Leu Gln Cys Glu Ala Ser Ala Val Pro Ser Ala Glu Phe Gln Trp Tyr 
                245                 250                 255     


Lys Asp Asp Lys Arg Leu Ile Glu Gly Lys Lys Gly Val Lys Val Glu 
            260                 265                 270         


Asn Arg Pro Phe Leu Ser Lys Leu Ile Phe Phe Asn Val Ser Glu His 
        275                 280                 285             


Asp Tyr Gly Asn Tyr Thr Cys Val Ala Ser Asn Lys Leu Gly His Thr 
    290                 295                 300                 


Asn Ala Ser Ile Met Leu Phe Gly Pro Gly Ala Val Ser Glu Val Ser 
305                 310                 315                 320 


Asn Gly Thr Ser Arg Arg Ala Gly Cys Val Trp Leu Leu Pro Leu Leu 
                325                 330                 335     


Val Leu His Leu Leu Leu Lys Phe 
            340                 


<210>  9618
<211>  18
<212>  PRT
<213>  Homo Sapiens

<400>  9618

Met Asn Gly Lys Arg Asn Gly Glu Gly Gly Lys Arg Trp Lys Trp Lys 
1               5                   10                  15      


Gly Thr 
        


<210>  9619
<211>  36
<212>  PRT
<213>  Homo Sapiens

<400>  9619

Met Asn Gly Lys Arg Asn Gly Glu Gly Gly Lys Arg Trp Lys Trp Lys 
1               5                   10                  15      


Gly Thr Gly Val Pro Val Arg Ser Gly Asp Ala Thr Phe Pro Lys Ala 
            20                  25                  30          


Met Asp Asn Val 
        35      


<210>  9620
<211>  191
<212>  PRT
<213>  Homo Sapiens

<400>  9620

Met Asn Gly Lys Arg Asn Gly Glu Gly Gly Lys Arg Trp Lys Trp Lys 
1               5                   10                  15      


Gly Thr Gly Val Pro Val Arg Ser Gly Asp Ala Thr Phe Pro Lys Ala 
            20                  25                  30          


Met Asp Asn Val Thr Val Arg Gln Gly Glu Ser Ala Thr Leu Arg Cys 
        35                  40                  45              


Thr Ile Asp Asn Arg Val Thr Arg Val Ala Trp Leu Asn Arg Ser Thr 
    50                  55                  60                  


Ile Leu Tyr Ala Gly Asn Asp Lys Trp Cys Leu Asp Pro Arg Val Val 
65                  70                  75                  80  


Leu Leu Ser Asn Thr Gln Thr Gln Tyr Ser Ile Glu Ile Gln Asn Val 
                85                  90                  95      


Asp Val Tyr Asp Glu Gly Pro Tyr Thr Cys Ser Val Gln Thr Asp Asn 
            100                 105                 110         


His Pro Lys Thr Ser Arg Val His Leu Ile Val Gln Val Ser Pro Lys 
        115                 120                 125             


Ile Val Glu Ile Ser Ser Asp Ile Ser Ile Asn Glu Gly Asn Asn Ile 
    130                 135                 140                 


Ser Leu Thr Cys Ile Ala Thr Gly Arg Pro Glu Pro Thr Val Thr Trp 
145                 150                 155                 160 


Arg His Ile Ser Pro Lys Ala Val Gly Phe Val Ser Glu Asp Glu Tyr 
                165                 170                 175     


Leu Glu Ile Gln Gly Ile Thr Arg Glu Gln Ser Gly Asp Tyr Glu 
            180                 185                 190     


<210>  9621
<211>  179
<212>  PRT
<213>  Homo Sapiens

<400>  9621

Val Gly Phe Val Ser Glu Asp Glu Tyr Leu Glu Ile Gln Gly Ile Thr 
1               5                   10                  15      


Arg Glu Gln Ser Gly Asp Tyr Glu Cys Ser Ala Ser Asn Asp Val Ala 
            20                  25                  30          


Ala Pro Val Val Arg Arg Val Lys Val Thr Val Asn Tyr Pro Pro Tyr 
        35                  40                  45              


Ile Ser Glu Ala Lys Gly Thr Gly Val Pro Val Gly Gln Lys Gly Thr 
    50                  55                  60                  


Leu Gln Cys Glu Ala Ser Ala Val Pro Ser Ala Glu Phe Gln Trp Tyr 
65                  70                  75                  80  


Lys Asp Asp Lys Arg Leu Ile Glu Gly Lys Lys Gly Val Lys Val Glu 
                85                  90                  95      


Asn Arg Pro Phe Leu Ser Lys Leu Ile Phe Phe Asn Val Ser Glu His 
            100                 105                 110         


Asp Tyr Gly Asn Tyr Thr Cys Val Ala Ser Asn Lys Leu Gly His Thr 
        115                 120                 125             


Asn Ala Ser Ile Met Leu Phe Glu Val Lys Thr Thr Ala Leu Thr Pro 
    130                 135                 140                 


Trp Lys Gly Pro Gly Ala Val Ser Glu Val Ser Asn Gly Thr Ser Arg 
145                 150                 155                 160 


Arg Ala Gly Cys Val Trp Leu Leu Pro Leu Leu Val Leu His Leu Leu 
                165                 170                 175     


Leu Lys Phe 
            


<210>  9622
<211>  168
<212>  PRT
<213>  Homo Sapiens

<400>  9622

Val Gly Phe Val Ser Glu Asp Glu Tyr Leu Glu Ile Gln Gly Ile Thr 
1               5                   10                  15      


Arg Glu Gln Ser Gly Asp Tyr Glu Cys Ser Ala Ser Asn Asp Val Ala 
            20                  25                  30          


Ala Pro Val Val Arg Arg Val Lys Val Thr Val Asn Tyr Pro Pro Tyr 
        35                  40                  45              


Ile Ser Glu Ala Lys Gly Thr Gly Val Pro Val Gly Gln Lys Gly Thr 
    50                  55                  60                  


Leu Gln Cys Glu Ala Ser Ala Val Pro Ser Ala Glu Phe Gln Trp Tyr 
65                  70                  75                  80  


Lys Asp Asp Lys Arg Leu Ile Glu Gly Lys Lys Gly Val Lys Val Glu 
                85                  90                  95      


Asn Arg Pro Phe Leu Ser Lys Leu Ile Phe Phe Asn Val Ser Glu His 
            100                 105                 110         


Asp Tyr Gly Asn Tyr Thr Cys Val Ala Ser Asn Lys Leu Gly His Thr 
        115                 120                 125             


Asn Ala Ser Ile Met Leu Phe Gly Pro Gly Ala Val Ser Glu Val Ser 
    130                 135                 140                 


Asn Gly Thr Ser Arg Arg Ala Gly Cys Val Trp Leu Leu Pro Leu Leu 
145                 150                 155                 160 


Val Leu His Leu Leu Leu Lys Phe 
                165             


<210>  9623
<211>  119
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9623

Xaa Ser Ala Glu Phe Gln Trp Tyr Lys Asp Asp Lys Arg Leu Ile Glu 
1               5                   10                  15      


Gly Lys Lys Gly Val Lys Val Glu Asn Arg Pro Phe Leu Ser Lys Leu 
            20                  25                  30          


Ile Phe Phe Asn Val Ser Glu His Asp Tyr Gly Asn Tyr Thr Cys Val 
        35                  40                  45              


Ala Ser Asn Lys Leu Gly His Thr Asn Ala Ser Ile Met Leu Phe Glu 
    50                  55                  60                  


Leu Asn Glu Pro Thr Ser Ser Thr Leu Leu Gln Glu Val Lys Thr Thr 
65                  70                  75                  80  


Ala Leu Thr Pro Trp Lys Gly Pro Gly Ala Val Ser Glu Val Ser Asn 
                85                  90                  95      


Gly Thr Ser Arg Arg Ala Gly Cys Val Trp Leu Leu Pro Leu Leu Val 
            100                 105                 110         


Leu His Leu Leu Leu Lys Phe 
        115                 


<210>  9624
<211>  153
<212>  PRT
<213>  Homo Sapiens

<400>  9624

His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly Lys Pro Ile Thr 
1               5                   10                  15      


His Arg Lys Ala Cys Lys Ala Cys Asp Cys His Pro Val Gly Ala Ala 
            20                  25                  30          


Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly 
        35                  40                  45              


Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser 
    50                  55                  60                  


Arg Ser Pro Ile Ala Pro Cys Ile Lys Ile Pro Val Ala Pro Pro Thr 
65                  70                  75                  80  


Thr Ala Ala Ser Ser Val Glu Glu Pro Glu Ala Ala Arg Gln Pro Asn 
                85                  90                  95      


Thr Phe Gln Ala Glu Gly Leu Ser Leu Leu Pro Gly Ala Ala Glu Lys 
            100                 105                 110         


Glu Gly Ala Arg Cys Trp Gly Tyr Arg Arg Arg Leu Gly His Arg Val 
        115                 120                 125             


Ala Gln Ala Glu Cys Arg Gly Pro Arg Ser Trp Ala Trp Gly Arg Ile 
    130                 135                 140                 


Thr Ser Ser Phe Ser Phe Ala Ser Asn 
145                 150             


<210>  9625
<211>  604
<212>  PRT
<213>  Homo Sapiens

<400>  9625

Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala 
1               5                   10                  15      


Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala 
            20                  25                  30          


Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro 
        35                  40                  45              


Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
    50                  55                  60                  


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
65                  70                  75                  80  


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
                85                  90                  95      


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
            100                 105                 110         


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
        115                 120                 125             


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
    130                 135                 140                 


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
145                 150                 155                 160 


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
                165                 170                 175     


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
            180                 185                 190         


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
        195                 200                 205             


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
    210                 215                 220                 


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
225                 230                 235                 240 


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
                245                 250                 255     


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
            260                 265                 270         


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn 
        275                 280                 285             


Gly His Ala Ala Arg Cys Val Arg Asp Arg Asp Asp Ser Leu Val Cys 
    290                 295                 300                 


Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro 
305                 310                 315                 320 


Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Ala Arg Glu Ala Asn 
                325                 330                 335     


Glu Cys Val Ala Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe 
            340                 345                 350         


Asn Met Glu Leu Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys 
        355                 360                 365             


Leu Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys 
    370                 375                 380                 


Glu Gly Tyr Tyr Arg Asp Met Gly Lys Pro Ile Thr His Arg Lys Ala 
385                 390                 395                 400 


Cys Lys Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr Cys 
                405                 410                 415     


Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly Ile 
            420                 425                 430         


Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro Ile 
        435                 440                 445             


Ala Pro Cys Ile Lys Ile Pro Val Ala Pro Pro Thr Thr Ala Ala Ser 
    450                 455                 460                 


Ser Val Glu Glu Pro Glu Asp Cys Asp Ser Tyr Cys Lys Ala Ser Lys 
465                 470                 475                 480 


Gly Lys Leu Lys Ile Asn Met Lys Lys Tyr Cys Lys Lys Asp Tyr Ala 
                485                 490                 495     


Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp Lys 
            500                 505                 510         


Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg Ile 
        515                 520                 525             


Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala Cys 
    530                 535                 540                 


Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly Asn 
545                 550                 555                 560 


Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser Ser 
                565                 570                 575     


Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys Phe 
            580                 585                 590         


Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala 
        595                 600                 


<210>  9626
<211>  580
<212>  PRT
<213>  Homo Sapiens

<400>  9626

Met Pro Gly Trp Pro Trp Gly Leu Leu Leu Thr Ala Gly Thr Leu Phe 
1               5                   10                  15      


Ala Ala Leu Ser Pro Gly Pro Pro Ala Pro Ala Asp Pro Cys His Asp 
            20                  25                  30          


Glu Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala 
        35                  40                  45              


Leu Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr 
    50                  55                  60                  


Arg Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu 
65                  70                  75                  80  


Leu Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu 
                85                  90                  95      


Ser Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly 
            100                 105                 110         


Lys Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro 
        115                 120                 125             


Pro Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp 
    130                 135                 140                 


Ala Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg 
145                 150                 155                 160 


Leu Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu 
                165                 170                 175     


Cys Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala 
            180                 185                 190         


Phe Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser 
        195                 200                 205             


Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu 
    210                 215                 220                 


Thr Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val 
225                 230                 235                 240 


Pro Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly Arg Cys Lys 
                245                 250                 255     


Cys Asn Gly His Ala Ser Arg Cys Leu Leu Asp Thr Gln Gly His Leu 
            260                 265                 270         


Ile Cys Asp Cys Arg His Gly Thr Glu Gly Pro Asp Cys Gly Arg Cys 
        275                 280                 285             


Lys Pro Phe Tyr Cys Asp Arg Pro Trp Gln Arg Ala Thr Ala Arg Glu 
    290                 295                 300                 


Ser His Ala Cys Leu Ala Cys Ser Cys Asn Gly His Ala Arg Arg Cys 
305                 310                 315                 320 


Arg Phe Asn Met Glu Leu Tyr Arg Leu Ser Gly Arg Arg Ser Gly Gly 
                325                 330                 335     


Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr 
            340                 345                 350         


Cys Arg Glu Gly Phe Tyr Arg Asp Pro Gly Arg Ala Leu Ser Asp Arg 
        355                 360                 365             


Arg Ala Cys Arg Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys 
    370                 375                 380                 


Thr Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr 
385                 390                 395                 400 


Gly Leu Thr Cys Asn Arg Cys Ala Pro Gly Phe Gln Gln Ser Arg Ser 
                405                 410                 415     


Pro Val Ala Pro Cys Val Lys Thr Pro Ile Pro Gly Pro Thr Glu Asp 
            420                 425                 430         


Ser Ser Pro Val Gln Pro Gln Asp Cys Asp Ser His Cys Lys Pro Ala 
        435                 440                 445             


Arg Gly Ser Tyr Arg Ile Ser Leu Lys Lys Phe Cys Lys Lys Asp Tyr 
    450                 455                 460                 


Ala Val Gln Val Ala Val Gly Ala Arg Gly Glu Ala Arg Gly Ala Trp 
465                 470                 475                 480 


Thr Arg Phe Pro Val Ala Val Leu Ala Val Phe Arg Ser Gly Glu Glu 
                485                 490                 495     


Arg Ala Arg Arg Gly Ser Ser Ala Leu Trp Val Pro Ala Gly Asp Ala 
            500                 505                 510         


Ala Cys Gly Cys Pro Arg Leu Leu Pro Gly Arg Arg Tyr Leu Leu Leu 
        515                 520                 525             


Gly Gly Gly Pro Gly Ala Ala Ala Gly Gly Ala Gly Gly Arg Gly Pro 
    530                 535                 540                 


Gly Leu Ile Ala Ala Arg Gly Ser Leu Val Leu Pro Trp Arg Asp Ala 
545                 550                 555                 560 


Trp Thr Arg Arg Leu Arg Arg Leu Gln Arg Arg Glu Arg Arg Gly Arg 
                565                 570                 575     


Cys Ser Ala Ala 
            580 


<210>  9627
<211>  176
<212>  PRT
<213>  Homo Sapiens

<400>  9627

Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr Thr Cys 
1               5                   10                  15      


Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn Thr Asp 
            20                  25                  30          


Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala Tyr Pro 
        35                  40                  45              


His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe Arg Phe 
    50                  55                  60                  


Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu Lys Ile 
65                  70                  75                  80  


Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile Val Met 
                85                  90                  95      


Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser Gln Asp 
            100                 105                 110         


Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn Cys Ser 
        115                 120                 125             


Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala Ile Cys 
    130                 135                 140                 


Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu Val Ile 
145                 150                 155                 160 


Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu Asn Pro Tyr Ser Ala 
                165                 170                 175     


<210>  9628
<211>  591
<212>  PRT
<213>  Homo Sapiens

<400>  9628

Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr Thr Cys 
1               5                   10                  15      


Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn Thr Asp 
            20                  25                  30          


Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala Tyr Pro 
        35                  40                  45              


His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe Arg Phe 
    50                  55                  60                  


Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu Lys Ile 
65                  70                  75                  80  


Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile Val Met 
                85                  90                  95      


Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser Gln Asp 
            100                 105                 110         


Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn Cys Ser 
        115                 120                 125             


Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala Ile Cys 
    130                 135                 140                 


Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu Val Ile 
145                 150                 155                 160 


Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu Asn Pro Tyr Ser Ala 
                165                 170                 175     


Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln Leu Leu 
            180                 185                 190         


Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu Glu Pro 
        195                 200                 205             


Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys Gly Ser 
    210                 215                 220                 


Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His Gly Phe 
225                 230                 235                 240 


Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly Lys Cys 
                245                 250                 255     


Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys Ala Pro 
            260                 265                 270         


Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Gly Lys Thr Gly Ala 
        275                 280                 285             


Pro Asn Glu Cys Arg Thr Cys Lys Cys Asn Gly His Ala Asp Thr Cys 
    290                 295                 300                 


His Phe Asp Val Asn Val Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly 
305                 310                 315                 320 


Val Cys Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg 
                325                 330                 335     


Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser Ala Pro 
            340                 345                 350         


Asp Ala Cys Lys Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu 
        355                 360                 365             


Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro 
    370                 375                 380                 


Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly 
385                 390                 395                 400 


Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg Pro Cys Asp Cys Ala Gly 
                405                 410                 415     


Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile Ser Ser His Thr Asp Ile 
            420                 425                 430         


Asp Trp Tyr His Glu Val Pro Asp Phe Arg Pro Val His Asn Lys Ser 
        435                 440                 445             


Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln Gly Phe Ser Ala Leu Leu 
    450                 455                 460                 


His Ser Gly Lys Cys Glu Cys Lys Glu Gln Thr Leu Gly Asn Ala Lys 
465                 470                 475                 480 


Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu 
                485                 490                 495     


Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys Ile Lys 
            500                 505                 510         


Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr 
        515                 520                 525             


Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu 
    530                 535                 540                 


Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr 
545                 550                 555                 560 


Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp Lys Pro 
                565                 570                 575     


Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys Lys 
            580                 585                 590     


<210>  9629
<211>  591
<212>  PRT
<213>  Homo Sapiens

<400>  9629

Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr Thr Cys 
1               5                   10                  15      


Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn Thr Asp 
            20                  25                  30          


Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala Tyr Pro 
        35                  40                  45              


His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe Arg Phe 
    50                  55                  60                  


Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu Lys Ile 
65                  70                  75                  80  


Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile Val Met 
                85                  90                  95      


Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser Gln Asp 
            100                 105                 110         


Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn Cys Ser 
        115                 120                 125             


Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala Ile Cys 
    130                 135                 140                 


Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu Val Ile 
145                 150                 155                 160 


Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu Asn Pro Tyr Ser Ala 
                165                 170                 175     


Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln Leu Leu 
            180                 185                 190         


Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu Glu Pro 
        195                 200                 205             


Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys Gly Ser 
    210                 215                 220                 


Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His Gly Phe 
225                 230                 235                 240 


Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly Lys Cys 
                245                 250                 255     


Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys Ala Pro 
            260                 265                 270         


Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Gly Lys Thr Gly Ala 
        275                 280                 285             


Pro Asn Glu Cys Arg Thr Cys Lys Cys Asn Gly His Ala Asp Thr Cys 
    290                 295                 300                 


His Phe Asp Val Asn Val Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly 
305                 310                 315                 320 


Val Cys Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg 
                325                 330                 335     


Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser Ala Pro 
            340                 345                 350         


Asp Ala Cys Lys Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu 
        355                 360                 365             


Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro 
    370                 375                 380                 


Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly 
385                 390                 395                 400 


Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg Pro Cys Asp Cys Ala Gly 
                405                 410                 415     


Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile Ser Ser His Thr Asp Ile 
            420                 425                 430         


Asp Trp Tyr His Glu Val Pro Asp Phe Arg Pro Val His Asn Lys Ser 
        435                 440                 445             


Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln Gly Phe Ser Ala Leu Leu 
    450                 455                 460                 


His Ser Gly Lys Cys Glu Cys Lys Glu Gln Thr Leu Gly Asn Ala Lys 
465                 470                 475                 480 


Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu 
                485                 490                 495     


Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys Ile Lys 
            500                 505                 510         


Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr 
        515                 520                 525             


Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu 
    530                 535                 540                 


Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr 
545                 550                 555                 560 


Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp Lys Pro 
                565                 570                 575     


Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys Lys 
            580                 585                 590     


<210>  9630
<211>  628
<212>  PRT
<213>  Homo Sapiens

<400>  9630

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile 
            260                 265                 270         


Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met 
        275                 280                 285             


Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys 
    290                 295                 300                 


Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp 
305                 310                 315                 320 


Gly Lys Thr Gly Ala Pro Asn Glu Cys Arg Thr Cys Lys Cys Asn Gly 
                325                 330                 335     


His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser Gly 
            340                 345                 350         


Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu Gly 
        355                 360                 365             


Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg 
    370                 375                 380                 


Pro Phe Ser Ala Pro Asp Ala Cys Lys Pro Cys Ser Cys His Pro Val 
385                 390                 395                 400 


Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser 
                405                 410                 415     


Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp 
            420                 425                 430         


Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg Pro 
        435                 440                 445             


Cys Asp Cys Ala Gly Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile Ser 
    450                 455                 460                 


Ser His Thr Asp Ile Asp Trp Tyr His Glu Val Pro Asp Phe Arg Pro 
465                 470                 475                 480 


Val His Asn Lys Ser Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln Gly 
                485                 490                 495     


Phe Ser Ala Leu Leu His Ser Gly Lys Cys Glu Cys Lys Glu Gln Thr 
            500                 505                 510         


Leu Gly Asn Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu 
        515                 520                 525             


Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val 
    530                 535                 540                 


Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe 
545                 550                 555                 560 


Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys 
                565                 570                 575     


Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His 
            580                 585                 590         


Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val 
        595                 600                 605             


Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys 
    610                 615                 620                 


Arg Glu Cys Lys 
625             


<210>  9631
<211>  605
<212>  PRT
<213>  Homo Sapiens

<400>  9631

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile 
            260                 265                 270         


Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met 
        275                 280                 285             


Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys 
    290                 295                 300                 


Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp 
305                 310                 315                 320 


Gly Lys Thr Gly Ala Pro Asn Glu Cys Arg Thr Cys Lys Cys Asn Gly 
                325                 330                 335     


His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser Gly 
            340                 345                 350         


Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu Gly 
        355                 360                 365             


Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg 
    370                 375                 380                 


Pro Phe Ser Ala Pro Asp Ala Cys Lys Pro Cys Ser Cys His Pro Val 
385                 390                 395                 400 


Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser 
                405                 410                 415     


Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp 
            420                 425                 430         


Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg Pro 
        435                 440                 445             


Cys Asp Cys Ala Gly Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile Ser 
    450                 455                 460                 


Ser His Thr Asp Ile Asp Trp Tyr His Glu Val Pro Asp Phe Arg Pro 
465                 470                 475                 480 


Val His Asn Lys Ser Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln Gly 
                485                 490                 495     


Phe Ser Ala Leu Leu His Ser Val Leu Lys Ile Lys Ile Leu Ser Ala 
            500                 505                 510         


His Asp Lys Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val 
        515                 520                 525             


Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr 
    530                 535                 540                 


Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro 
545                 550                 555                 560 


Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys 
                565                 570                 575     


Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu 
            580                 585                 590         


Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys Lys 
        595                 600                 605 


<210>  9632
<211>  75
<212>  PRT
<213>  Homo Sapiens

<400>  9632

Met Pro Cys Gln Arg Ile Pro Glu Ala Thr Thr Thr Leu Ala Thr Thr 
1               5                   10                  15      


Pro Gly Ala Tyr Ser Ser Asp Pro Gln Cys Gln Asn Tyr Cys Asn Met 
            20                  25                  30          


Ser Asp Thr Arg Val His Met Ser Leu Arg Arg Tyr Cys Gln Gln Asp 
        35                  40                  45              


His Val Leu Arg Ala Gln Val Leu Ala Ser Glu Ala Ala Gly Pro Ala 
    50                  55                  60                  


Trp Gln Arg Leu Ala Val Arg Val Leu Ala Val 
65                  70                  75  


<210>  9633
<211>  489
<212>  PRT
<213>  Homo Sapiens

<400>  9633

Met Pro Val Thr Phe Ala Leu Leu Leu Leu Leu Gly Gln Ala Thr Ala 
1               5                   10                  15      


Asp Pro Cys Tyr Asp Pro Gln Gly Arg Pro Gln Phe Cys Leu Pro Pro 
            20                  25                  30          


Val Thr Gln Leu Ala Ala Val Ala Ala Ser Cys Pro Gln Ala Cys Ala 
        35                  40                  45              


Leu Ser Pro Gly Asn His Leu Gly Ala Arg Glu Thr Cys Asn Gly Ser 
    50                  55                  60                  


Leu Thr Leu Ala Leu Gly Gly Pro Phe Leu Leu Thr Ser Val Ser Leu 
65                  70                  75                  80  


Arg Phe Cys Thr Pro Gly Pro Pro Ala Leu Ile Leu Ser Ala Ala Trp 
                85                  90                  95      


Ala Ser Gly Gly Pro Trp Arg Leu Leu Trp His Arg Pro Ala Trp Pro 
            100                 105                 110         


Gly Ala Leu Gly Gly Pro Glu Arg Val Thr Phe His Ser Thr Pro Gly 
        115                 120                 125             


Pro Lys Ala Thr Val Ala Ala Ser His Leu Arg Val Glu Phe Gly Gly 
    130                 135                 140                 


Gln Ala Gly Leu Ala Ala Ala Gly Leu Arg Gly Arg Cys Gln Cys His 
145                 150                 155                 160 


Gly His Ala Ala Arg Cys Ala Ala Arg Ala Arg Pro Pro Arg Cys His 
                165                 170                 175     


Cys Arg His His Thr Thr Gly Pro Gly Cys Glu Ser Cys Arg Pro Ser 
            180                 185                 190         


His Arg Asp Trp Pro Trp Arg Pro Ala Thr Pro Arg His Pro His Pro 
        195                 200                 205             


Cys Leu Pro Cys Ser Cys Asn Gln His Ala Arg Arg Cys Arg Phe Asn 
    210                 215                 220                 


Ser Glu Leu Phe Arg Leu Ser Gly Gly Arg Ser Gly Gly Val Cys Glu 
225                 230                 235                 240 


Arg Cys Arg His His Thr Ala Gly Arg His Cys His Tyr Cys Gln Pro 
                245                 250                 255     


Gly Phe Trp Arg Asp Pro Ser Gln Pro Ile Phe Ser Arg Arg Ala Cys 
            260                 265                 270         


Arg Ala Cys Gln Cys His Pro Ile Gly Ala Thr Gly Gly Thr Cys Asn 
        275                 280                 285             


Gln Thr Ser Gly Gln Cys Thr Cys Lys Leu Gly Val Thr Gly Leu Thr 
    290                 295                 300                 


Cys Asn Arg Cys Gly Pro Gly Tyr Gln Gln Ser Arg Ser Pro Arg Met 
305                 310                 315                 320 


Pro Cys Gln Arg Ile Pro Glu Ala Thr Thr Thr Leu Ala Thr Thr Pro 
                325                 330                 335     


Gly Ala Tyr Ser Ser Asp Pro Gln Cys Gln Asn Tyr Cys Asn Met Ser 
            340                 345                 350         


Asp Thr Arg Val His Met Ser Leu Arg Arg Tyr Cys Gln Gln Asp His 
        355                 360                 365             


Val Leu Arg Ala Gln Val Leu Ala Ser Glu Ala Ala Gly Pro Ala Trp 
    370                 375                 380                 


Gln Arg Leu Ala Val Arg Val Leu Ala Val Tyr Lys Gln Arg Ala Gln 
385                 390                 395                 400 


Pro Val Arg Arg Gly Asp Gln Asp Ala Trp Val Pro Arg Ala Asp Leu 
                405                 410                 415     


Thr Cys Gly Cys Leu Arg Leu Gln Pro Gly Thr Asp Tyr Leu Leu Leu 
            420                 425                 430         


Gly Ser Ala Val Gly Asp Pro Asp Pro Thr Arg Leu Ile Leu Asp Arg 
        435                 440                 445             


His Gly Leu Ala Leu Pro Trp Arg Pro Arg Trp Ala Arg Pro Leu Lys 
    450                 455                 460                 


Arg Leu Gln Gln Glu Glu Arg Ala Gly Gly Cys Arg Gly Val Arg Ala 
465                 470                 475                 480 


Pro Thr Pro Ser Pro Arg Pro Glu His 
                485                 


<210>  9634
<211>  480
<212>  PRT
<213>  Homo Sapiens

<400>  9634

Met Tyr Leu Ser Arg Phe Leu Ser Ile His Ala Leu Trp Val Thr Val 
1               5                   10                  15      


Ser Ser Val Met Gln Pro Tyr Pro Leu Val Trp Gly His Tyr Asp Leu 
            20                  25                  30          


Cys Lys Thr Gln Ile Tyr Thr Glu Glu Gly Lys Val Trp Asp Tyr Met 
        35                  40                  45              


Ala Cys Gln Pro Glu Ser Thr Asp Met Thr Lys Tyr Leu Lys Val Lys 
    50                  55                  60                  


Leu Asp Pro Pro Asp Ile Thr Cys Gly Asp Pro Pro Glu Thr Phe Cys 
65                  70                  75                  80  


Ala Met Gly Asn Pro Tyr Met Cys Asn Asn Glu Cys Asp Ala Ser Thr 
                85                  90                  95      


Pro Glu Leu Ala His Pro Pro Glu Leu Met Phe Asp Phe Glu Gly Arg 
            100                 105                 110         


His Pro Ser Thr Phe Trp Gln Ser Ala Thr Trp Lys Glu Tyr Pro Lys 
        115                 120                 125             


Pro Leu Gln Val Asn Ile Thr Leu Ser Trp Ser Lys Thr Ile Glu Leu 
    130                 135                 140                 


Thr Asp Asn Ile Val Ile Thr Phe Glu Ser Gly Arg Pro Asp Gln Met 
145                 150                 155                 160 


Ile Leu Glu Lys Ser Leu Asp Tyr Gly Arg Thr Trp Gln Pro Tyr Gln 
                165                 170                 175     


Tyr Tyr Ala Thr Asp Cys Leu Asp Ala Phe His Met Asp Pro Lys Ser 
            180                 185                 190         


Val Lys Asp Leu Ser Gln His Thr Val Leu Glu Ile Ile Cys Thr Glu 
        195                 200                 205             


Glu Tyr Ser Thr Gly Tyr Thr Thr Asn Ser Lys Ile Ile His Phe Glu 
    210                 215                 220                 


Ile Lys Asp Arg Phe Ala Phe Phe Ala Gly Pro Arg Leu Arg Asn Met 
225                 230                 235                 240 


Ala Ser Leu Tyr Gly Gln Leu Asp Thr Thr Lys Lys Leu Arg Asp Phe 
                245                 250                 255     


Phe Thr Val Thr Asp Leu Arg Ile Arg Leu Leu Arg Pro Ala Val Gly 
            260                 265                 270         


Glu Ile Phe Val Asp Glu Leu His Leu Ala Arg Tyr Phe Tyr Ala Ile 
        275                 280                 285             


Ser Asp Ile Lys Val Arg Gly Arg Cys Lys Cys Asn Leu His Ala Thr 
    290                 295                 300                 


Val Cys Val Tyr Asp Asn Ser Lys Leu Thr Cys Glu Cys Glu His Asn 
305                 310                 315                 320 


Thr Thr Gly Pro Asp Cys Gly Lys Cys Lys Lys Asn Tyr Gln Gly Arg 
                325                 330                 335     


Pro Trp Ser Pro Gly Ser Tyr Leu Pro Ile Pro Lys Gly Thr Ala Asn 
            340                 345                 350         


Thr Cys Ile Pro Ser Ile Ser Ser Ile Gly Asn Pro Pro Lys Phe Asn 
        355                 360                 365             


Arg Ile Trp Pro Asn Ile Ser Ser Leu Glu Val Ser Asn Pro Lys Gln 
    370                 375                 380                 


Val Ala Pro Lys Leu Ala Leu Ser Thr Val Ser Ser Val Gln Val Ala 
385                 390                 395                 400 


Asn His Lys Arg Ala Asn Val Cys Asp Asn Glu Leu Leu His Cys Gln 
                405                 410                 415     


Asn Gly Gly Thr Cys His Asn Asn Val Arg Cys Leu Cys Pro Ala Ala 
            420                 425                 430         


Tyr Thr Gly Ile Leu Cys Glu Lys Leu Arg Cys Glu Glu Ala Gly Ser 
        435                 440                 445             


Cys Gly Ser Asp Ser Gly Gln Gly Ala Pro Pro His Gly Ser Pro Ala 
    450                 455                 460                 


Leu Leu Leu Leu Thr Thr Leu Leu Gly Thr Ala Ser Pro Leu Val Phe 
465                 470                 475                 480 


<210>  9635
<211>  539
<212>  PRT
<213>  Homo Sapiens

<400>  9635

Met Tyr Leu Ser Arg Phe Leu Ser Ile His Ala Leu Trp Val Thr Val 
1               5                   10                  15      


Ser Ser Val Met Gln Pro Tyr Pro Leu Val Trp Gly His Tyr Asp Leu 
            20                  25                  30          


Cys Lys Thr Gln Ile Tyr Thr Glu Glu Gly Lys Val Trp Asp Tyr Met 
        35                  40                  45              


Ala Cys Gln Pro Glu Ser Thr Asp Met Thr Lys Tyr Leu Lys Val Lys 
    50                  55                  60                  


Leu Asp Pro Pro Asp Ile Thr Cys Gly Asp Pro Pro Glu Thr Phe Cys 
65                  70                  75                  80  


Ala Met Gly Asn Pro Tyr Met Cys Asn Asn Glu Cys Asp Ala Ser Thr 
                85                  90                  95      


Pro Glu Leu Ala His Pro Pro Glu Leu Met Phe Asp Phe Glu Gly Arg 
            100                 105                 110         


His Pro Ser Thr Phe Trp Gln Ser Ala Thr Trp Lys Glu Tyr Pro Lys 
        115                 120                 125             


Pro Leu Gln Val Asn Ile Thr Leu Ser Trp Ser Lys Thr Ile Glu Leu 
    130                 135                 140                 


Thr Asp Asn Ile Val Ile Thr Phe Glu Ser Gly Arg Pro Asp Gln Met 
145                 150                 155                 160 


Ile Leu Glu Lys Ser Leu Asp Tyr Gly Arg Thr Trp Gln Pro Tyr Gln 
                165                 170                 175     


Tyr Tyr Ala Thr Asp Cys Leu Asp Ala Phe His Met Asp Pro Lys Ser 
            180                 185                 190         


Val Lys Asp Leu Ser Gln His Thr Val Leu Glu Ile Ile Cys Thr Glu 
        195                 200                 205             


Glu Tyr Ser Thr Gly Tyr Thr Thr Asn Ser Lys Ile Ile His Phe Glu 
    210                 215                 220                 


Ile Lys Asp Arg Phe Ala Phe Phe Ala Gly Pro Arg Leu Arg Asn Met 
225                 230                 235                 240 


Ala Ser Leu Tyr Gly Gln Leu Asp Thr Thr Lys Lys Leu Arg Asp Phe 
                245                 250                 255     


Phe Thr Val Thr Asp Leu Arg Ile Arg Leu Leu Arg Pro Ala Val Gly 
            260                 265                 270         


Glu Ile Phe Val Asp Glu Leu His Leu Ala Arg Tyr Phe Tyr Ala Ile 
        275                 280                 285             


Ser Asp Ile Lys Val Arg Gly Arg Cys Lys Cys Asn Leu His Ala Thr 
    290                 295                 300                 


Val Cys Val Tyr Asp Asn Ser Lys Leu Thr Cys Glu Cys Glu His Asn 
305                 310                 315                 320 


Thr Thr Gly Pro Asp Cys Gly Lys Cys Lys Lys Asn Tyr Gln Gly Arg 
                325                 330                 335     


Pro Trp Ser Pro Gly Ser Tyr Leu Pro Ile Pro Lys Gly Thr Ala Asn 
            340                 345                 350         


Thr Cys Ile Pro Ser Ile Ser Ser Ile Gly Asn Cys Glu Cys Phe Gly 
        355                 360                 365             


His Ser Asn Arg Cys Ser Tyr Ile Asp Leu Leu Asn Thr Val Ile Cys 
    370                 375                 380                 


Val Ser Cys Lys His Asn Thr Arg Gly Gln His Cys Glu Leu Cys Arg 
385                 390                 395                 400 


Leu Gly Tyr Phe Arg Asn Ala Ser Ala Gln Leu Asp Asp Glu Asn Val 
                405                 410                 415     


Cys Ile Glu Cys Tyr Cys Asn Pro Leu Gly Ser Ile His Asp Arg Cys 
            420                 425                 430         


Asn Gly Ser Gly Phe Cys Glu Cys Lys Thr Gly Thr Thr Gly Pro Lys 
        435                 440                 445             


Cys Asp Glu Cys Leu Pro Gly Asn Ser Trp His Tyr Gly Cys Gln Pro 
    450                 455                 460                 


Asn Val Cys Asp Asn Glu Leu Leu His Cys Gln Asn Gly Gly Thr Cys 
465                 470                 475                 480 


His Asn Asn Val Arg Cys Leu Cys Pro Ala Ala Tyr Thr Gly Ile Leu 
                485                 490                 495     


Cys Glu Lys Leu Arg Cys Glu Glu Ala Gly Ser Cys Gly Ser Asp Ser 
            500                 505                 510         


Gly Gln Gly Ala Pro Pro His Gly Ser Pro Ala Leu Leu Leu Leu Thr 
        515                 520                 525             


Thr Leu Leu Gly Thr Ala Ser Pro Leu Val Phe 
    530                 535                 


<210>  9636
<211>  539
<212>  PRT
<213>  Homo Sapiens

<400>  9636

Met Tyr Leu Ser Arg Phe Leu Ser Ile His Ala Leu Trp Val Thr Val 
1               5                   10                  15      


Ser Ser Val Met Gln Pro Tyr Pro Leu Val Trp Gly His Tyr Asp Leu 
            20                  25                  30          


Cys Lys Thr Gln Ile Tyr Thr Glu Glu Gly Lys Val Trp Asp Tyr Met 
        35                  40                  45              


Ala Cys Gln Pro Glu Ser Thr Asp Met Thr Lys Tyr Leu Lys Val Lys 
    50                  55                  60                  


Leu Asp Pro Pro Asp Ile Thr Cys Gly Asp Pro Pro Glu Thr Phe Cys 
65                  70                  75                  80  


Ala Met Gly Asn Pro Tyr Met Cys Asn Asn Glu Cys Asp Ala Ser Thr 
                85                  90                  95      


Pro Glu Leu Ala His Pro Pro Glu Leu Met Phe Asp Phe Glu Gly Arg 
            100                 105                 110         


His Pro Ser Thr Phe Trp Gln Ser Ala Thr Trp Lys Glu Tyr Pro Lys 
        115                 120                 125             


Pro Leu Gln Val Asn Ile Thr Leu Ser Trp Ser Lys Thr Ile Glu Leu 
    130                 135                 140                 


Thr Asp Asn Ile Val Ile Thr Phe Glu Ser Gly Arg Pro Asp Gln Met 
145                 150                 155                 160 


Ile Leu Glu Lys Ser Leu Asp Tyr Gly Arg Thr Trp Gln Pro Tyr Gln 
                165                 170                 175     


Tyr Tyr Ala Thr Asp Cys Leu Asp Ala Phe His Met Asp Pro Lys Ser 
            180                 185                 190         


Val Lys Asp Leu Ser Gln His Thr Val Leu Glu Ile Ile Cys Thr Glu 
        195                 200                 205             


Glu Tyr Ser Thr Gly Tyr Thr Thr Asn Ser Lys Ile Ile His Phe Glu 
    210                 215                 220                 


Ile Lys Asp Arg Phe Ala Phe Phe Ala Gly Pro Arg Leu Arg Asn Met 
225                 230                 235                 240 


Ala Ser Leu Tyr Gly Gln Leu Asp Thr Thr Lys Lys Leu Arg Asp Phe 
                245                 250                 255     


Phe Thr Val Thr Asp Leu Arg Ile Arg Leu Leu Arg Pro Ala Val Gly 
            260                 265                 270         


Glu Ile Phe Val Asp Glu Leu His Leu Ala Arg Tyr Phe Tyr Ala Ile 
        275                 280                 285             


Ser Asp Ile Lys Val Arg Gly Arg Cys Lys Cys Asn Leu His Ala Thr 
    290                 295                 300                 


Val Cys Val Tyr Asp Asn Ser Lys Leu Thr Cys Glu Cys Glu His Asn 
305                 310                 315                 320 


Thr Thr Gly Pro Asp Cys Gly Lys Cys Lys Lys Asn Tyr Gln Gly Arg 
                325                 330                 335     


Pro Trp Ser Pro Gly Ser Tyr Leu Pro Ile Pro Lys Gly Thr Ala Asn 
            340                 345                 350         


Thr Cys Ile Pro Ser Ile Ser Ser Ile Gly Asn Cys Glu Cys Phe Gly 
        355                 360                 365             


His Ser Asn Arg Cys Ser Tyr Ile Asp Leu Leu Asn Thr Val Ile Cys 
    370                 375                 380                 


Val Ser Cys Lys His Asn Thr Arg Gly Gln His Cys Glu Leu Cys Arg 
385                 390                 395                 400 


Leu Gly Tyr Phe Arg Asn Ala Ser Ala Gln Leu Asp Asp Glu Asn Val 
                405                 410                 415     


Cys Ile Glu Cys Tyr Cys Asn Pro Leu Gly Ser Ile His Asp Arg Cys 
            420                 425                 430         


Asn Gly Ser Gly Phe Cys Glu Cys Lys Thr Gly Thr Thr Gly Pro Lys 
        435                 440                 445             


Cys Asp Glu Cys Leu Pro Gly Asn Ser Trp His Tyr Gly Cys Gln Pro 
    450                 455                 460                 


Asn Val Cys Asp Asn Glu Leu Leu His Cys Gln Asn Gly Gly Thr Cys 
465                 470                 475                 480 


His Asn Asn Val Arg Cys Leu Cys Pro Ala Ala Tyr Thr Gly Ile Leu 
                485                 490                 495     


Cys Glu Lys Leu Arg Cys Glu Glu Ala Gly Ser Cys Gly Ser Asp Ser 
            500                 505                 510         


Gly Gln Gly Ala Pro Pro His Gly Ser Pro Ala Leu Leu Leu Leu Thr 
        515                 520                 525             


Thr Leu Leu Gly Thr Ala Ser Pro Leu Val Phe 
    530                 535                 


<210>  9637
<211>  460
<212>  PRT
<213>  Homo Sapiens

<400>  9637

Met Tyr Leu Ser Arg Phe Leu Ser Ile His Ala Leu Trp Val Thr Val 
1               5                   10                  15      


Ser Ser Val Met Gln Pro Tyr Pro Leu Val Trp Gly His Tyr Asp Leu 
            20                  25                  30          


Cys Lys Thr Gln Ile Tyr Thr Glu Glu Gly Lys Val Trp Asp Tyr Met 
        35                  40                  45              


Ala Cys Gln Pro Glu Ser Thr Asp Met Thr Lys Tyr Leu Lys Val Lys 
    50                  55                  60                  


Leu Asp Pro Pro Asp Ile Thr Cys Gly Asp Pro Pro Glu Thr Phe Cys 
65                  70                  75                  80  


Ala Met Gly Asn Pro Tyr Met Cys Asn Asn Glu Cys Asp Ala Ser Thr 
                85                  90                  95      


Pro Glu Leu Ala His Pro Pro Glu Leu Met Phe Asp Phe Glu Gly Arg 
            100                 105                 110         


His Pro Ser Thr Phe Trp Gln Ser Ala Thr Trp Lys Glu Tyr Pro Lys 
        115                 120                 125             


Pro Leu Gln Val Asn Ile Thr Leu Ser Trp Ser Lys Thr Ile Glu Leu 
    130                 135                 140                 


Thr Asp Asn Ile Val Ile Thr Phe Glu Ser Gly Arg Pro Asp Gln Met 
145                 150                 155                 160 


Ile Leu Glu Lys Ser Leu Asp Tyr Gly Arg Thr Trp Gln Pro Tyr Gln 
                165                 170                 175     


Tyr Tyr Ala Thr Asp Cys Leu Asp Ala Phe His Met Asp Pro Lys Ser 
            180                 185                 190         


Val Lys Asp Leu Ser Gln His Thr Val Leu Glu Ile Ile Cys Thr Glu 
        195                 200                 205             


Glu Tyr Ser Thr Gly Tyr Thr Thr Asn Ser Lys Ile Ile His Phe Glu 
    210                 215                 220                 


Ile Lys Asp Arg Phe Ala Phe Phe Ala Gly Pro Arg Leu Arg Asn Met 
225                 230                 235                 240 


Ala Ser Leu Tyr Gly Gln Leu Asp Thr Thr Lys Lys Leu Arg Asp Phe 
                245                 250                 255     


Phe Thr Val Thr Asp Leu Arg Ile Arg Leu Leu Arg Pro Ala Val Gly 
            260                 265                 270         


Glu Ile Phe Val Asp Glu Leu His Leu Ala Arg Tyr Phe Tyr Ala Ile 
        275                 280                 285             


Ser Asp Ile Lys Val Arg Gly Arg Cys Lys Cys Asn Leu His Ala Thr 
    290                 295                 300                 


Val Cys Val Tyr Asp Asn Ser Lys Leu Thr Cys Glu Cys Glu His Asn 
305                 310                 315                 320 


Thr Thr Gly Pro Asp Cys Gly Lys Cys Lys Lys Asn Tyr Gln Gly Arg 
                325                 330                 335     


Pro Trp Ser Pro Gly Ser Tyr Leu Pro Ile Pro Lys Gly Thr Ala Asn 
            340                 345                 350         


Thr Cys Ile Pro Ser Ile Ser Ser Ile Gly Asn Pro Pro Lys Phe Asn 
        355                 360                 365             


Arg Ile Trp Pro Asn Ile Ser Ser Leu Glu Val Ser Asn Pro Lys Gln 
    370                 375                 380                 


Ala Asn Val Cys Asp Asn Glu Leu Leu His Cys Gln Asn Gly Gly Thr 
385                 390                 395                 400 


Cys His Asn Asn Val Arg Cys Leu Cys Pro Ala Ala Tyr Thr Gly Ile 
                405                 410                 415     


Leu Cys Glu Lys Leu Arg Cys Glu Glu Ala Gly Ser Cys Gly Ser Asp 
            420                 425                 430         


Ser Gly Gln Gly Ala Pro Pro His Gly Ser Pro Ala Leu Leu Leu Leu 
        435                 440                 445             


Thr Thr Leu Leu Gly Thr Ala Ser Pro Leu Val Phe 
    450                 455                 460 


<210>  9638
<211>  480
<212>  PRT
<213>  Homo Sapiens

<400>  9638

Met Tyr Leu Ser Arg Phe Leu Ser Ile His Ala Leu Trp Val Thr Val 
1               5                   10                  15      


Ser Ser Val Met Gln Pro Tyr Pro Leu Val Trp Gly His Tyr Asp Leu 
            20                  25                  30          


Cys Lys Thr Gln Ile Tyr Thr Glu Glu Gly Lys Val Trp Asp Tyr Met 
        35                  40                  45              


Ala Cys Gln Pro Glu Ser Thr Asp Met Thr Lys Tyr Leu Lys Val Lys 
    50                  55                  60                  


Leu Asp Pro Pro Asp Ile Thr Cys Gly Asp Pro Pro Glu Thr Phe Cys 
65                  70                  75                  80  


Ala Met Gly Asn Pro Tyr Met Cys Asn Asn Glu Cys Asp Ala Ser Thr 
                85                  90                  95      


Pro Glu Leu Ala His Pro Pro Glu Leu Met Phe Asp Phe Glu Gly Arg 
            100                 105                 110         


His Pro Ser Thr Phe Trp Gln Ser Ala Thr Trp Lys Glu Tyr Pro Lys 
        115                 120                 125             


Pro Leu Gln Val Asn Ile Thr Leu Ser Trp Ser Lys Thr Ile Glu Leu 
    130                 135                 140                 


Thr Asp Asn Ile Val Ile Thr Phe Glu Ser Gly Arg Pro Asp Gln Met 
145                 150                 155                 160 


Ile Leu Glu Lys Ser Leu Asp Tyr Gly Arg Thr Trp Gln Pro Tyr Gln 
                165                 170                 175     


Tyr Tyr Ala Thr Asp Cys Leu Asp Ala Phe His Met Asp Pro Lys Ser 
            180                 185                 190         


Val Lys Asp Leu Ser Gln His Thr Val Leu Glu Ile Ile Cys Thr Glu 
        195                 200                 205             


Glu Tyr Ser Thr Gly Tyr Thr Thr Asn Ser Lys Ile Ile His Phe Glu 
    210                 215                 220                 


Ile Lys Asp Arg Phe Ala Phe Phe Ala Gly Pro Arg Leu Arg Asn Met 
225                 230                 235                 240 


Ala Ser Leu Tyr Gly Gln Leu Asp Thr Thr Lys Lys Leu Arg Asp Phe 
                245                 250                 255     


Phe Thr Val Thr Asp Leu Arg Ile Arg Leu Leu Arg Pro Ala Val Gly 
            260                 265                 270         


Glu Ile Phe Val Asp Glu Leu His Leu Ala Arg Tyr Phe Tyr Ala Ile 
        275                 280                 285             


Ser Asp Ile Lys Val Arg Gly Arg Cys Lys Cys Asn Leu His Ala Thr 
    290                 295                 300                 


Val Cys Val Tyr Asp Asn Ser Lys Leu Thr Cys Glu Cys Glu His Asn 
305                 310                 315                 320 


Thr Thr Gly Pro Asp Cys Gly Lys Cys Lys Lys Asn Tyr Gln Gly Arg 
                325                 330                 335     


Pro Trp Ser Pro Gly Ser Tyr Leu Pro Ile Pro Lys Gly Thr Ala Asn 
            340                 345                 350         


Thr Cys Ile Pro Ser Ile Ser Ser Ile Gly Asn Pro Pro Lys Phe Asn 
        355                 360                 365             


Arg Ile Trp Pro Asn Ile Ser Ser Leu Glu Val Ser Asn Pro Lys Gln 
    370                 375                 380                 


Val Ala Pro Lys Leu Ala Leu Ser Thr Val Ser Ser Val Gln Val Ala 
385                 390                 395                 400 


Asn His Lys Arg Ala Asn Val Cys Asp Asn Glu Leu Leu His Cys Gln 
                405                 410                 415     


Asn Gly Gly Thr Cys His Asn Asn Val Arg Cys Leu Cys Pro Ala Ala 
            420                 425                 430         


Tyr Thr Gly Ile Leu Cys Glu Lys Leu Arg Cys Glu Glu Ala Gly Ser 
        435                 440                 445             


Cys Gly Ser Asp Ser Gly Gln Gly Ala Pro Pro His Gly Ser Pro Ala 
    450                 455                 460                 


Leu Leu Leu Leu Thr Thr Leu Leu Gly Thr Ala Ser Pro Leu Val Phe 
465                 470                 475                 480 


<210>  9639
<211>  438
<212>  PRT
<213>  Homo Sapiens

<400>  9639

Met Tyr Leu Ser Arg Phe Leu Ser Ile His Ala Leu Trp Val Thr Val 
1               5                   10                  15      


Ser Ser Val Met Gln Pro Tyr Pro Leu Val Trp Gly His Tyr Asp Leu 
            20                  25                  30          


Cys Lys Thr Gln Ile Tyr Thr Glu Glu Gly Lys Val Trp Asp Tyr Met 
        35                  40                  45              


Ala Cys Gln Pro Glu Ser Thr Asp Met Thr Lys Tyr Leu Lys Val Lys 
    50                  55                  60                  


Leu Asp Pro Pro Asp Ile Thr Cys Gly Asp Pro Pro Glu Thr Phe Cys 
65                  70                  75                  80  


Ala Met Gly Asn Pro Tyr Met Cys Asn Asn Glu Cys Asp Ala Ser Thr 
                85                  90                  95      


Pro Glu Leu Ala His Pro Pro Glu Leu Met Phe Asp Phe Glu Gly Arg 
            100                 105                 110         


His Pro Ser Thr Phe Trp Gln Ser Ala Thr Trp Lys Glu Tyr Pro Lys 
        115                 120                 125             


Pro Leu Gln Val Asn Ile Thr Leu Ser Trp Ser Lys Thr Ile Glu Leu 
    130                 135                 140                 


Thr Asp Asn Ile Val Ile Thr Phe Glu Ser Gly Arg Pro Asp Gln Met 
145                 150                 155                 160 


Ile Leu Glu Lys Ser Leu Asp Tyr Gly Arg Thr Trp Gln Pro Tyr Gln 
                165                 170                 175     


Tyr Tyr Ala Thr Asp Cys Leu Asp Ala Phe His Met Asp Pro Lys Ser 
            180                 185                 190         


Val Lys Asp Leu Ser Gln His Thr Val Leu Glu Ile Ile Cys Thr Glu 
        195                 200                 205             


Glu Tyr Ser Thr Gly Tyr Thr Thr Asn Ser Lys Ile Ile His Phe Glu 
    210                 215                 220                 


Ile Lys Asp Arg Phe Ala Phe Phe Ala Gly Pro Arg Leu Arg Asn Met 
225                 230                 235                 240 


Ala Ser Leu Tyr Gly Gln Leu Asp Thr Thr Lys Lys Leu Arg Asp Phe 
                245                 250                 255     


Phe Thr Val Thr Asp Leu Arg Ile Arg Leu Leu Arg Pro Ala Val Gly 
            260                 265                 270         


Glu Ile Phe Val Asp Glu Leu His Leu Ala Arg Tyr Phe Tyr Ala Ile 
        275                 280                 285             


Ser Asp Ile Lys Val Arg Gly Arg Cys Lys Cys Asn Leu His Ala Thr 
    290                 295                 300                 


Val Cys Val Tyr Asp Asn Ser Lys Leu Thr Cys Glu Cys Glu His Asn 
305                 310                 315                 320 


Thr Thr Gly Pro Asp Cys Gly Lys Cys Lys Lys Asn Tyr Gln Gly Arg 
                325                 330                 335     


Pro Trp Ser Pro Gly Ser Tyr Leu Pro Ile Pro Lys Gly Thr Ala Asn 
            340                 345                 350         


Thr Cys Ile Pro Ser Ile Ser Ser Ile Gly Thr Asn Val Cys Asp Asn 
        355                 360                 365             


Glu Leu Leu His Cys Gln Asn Gly Gly Thr Cys His Asn Asn Val Arg 
    370                 375                 380                 


Cys Leu Cys Pro Ala Ala Tyr Thr Gly Ile Leu Cys Glu Lys Leu Arg 
385                 390                 395                 400 


Cys Glu Glu Ala Gly Ser Cys Gly Ser Asp Ser Gly Gln Gly Ala Pro 
                405                 410                 415     


Pro His Gly Ser Pro Ala Leu Leu Leu Leu Thr Thr Leu Leu Gly Thr 
            420                 425                 430         


Ala Ser Pro Leu Val Phe 
        435             


<210>  9640
<211>  494
<212>  PRT
<213>  Homo Sapiens

<400>  9640

Met Tyr Leu Ser Arg Phe Leu Ser Ile His Ala Leu Trp Val Thr Val 
1               5                   10                  15      


Ser Ser Val Met Gln Pro Tyr Pro Leu Val Trp Gly His Tyr Asp Leu 
            20                  25                  30          


Cys Lys Thr Gln Ile Tyr Thr Glu Glu Gly Lys Val Trp Asp Tyr Met 
        35                  40                  45              


Ala Cys Gln Pro Glu Ser Thr Asp Met Thr Lys Tyr Leu Lys Val Lys 
    50                  55                  60                  


Leu Asp Pro Pro Asp Ile Thr Cys Gly Asp Pro Pro Glu Thr Phe Cys 
65                  70                  75                  80  


Ala Met Gly Asn Pro Tyr Met Cys Asn Asn Glu Cys Asp Ala Ser Thr 
                85                  90                  95      


Pro Glu Leu Ala His Pro Pro Glu Leu Met Phe Asp Phe Glu Gly Arg 
            100                 105                 110         


His Pro Ser Thr Phe Trp Gln Ser Ala Thr Trp Lys Glu Tyr Pro Lys 
        115                 120                 125             


Pro Leu Gln Val Asn Ile Thr Leu Ser Trp Ser Lys Thr Ile Glu Leu 
    130                 135                 140                 


Thr Asp Asn Ile Val Ile Thr Phe Glu Ser Gly Arg Pro Asp Gln Met 
145                 150                 155                 160 


Ile Leu Glu Lys Ser Leu Asp Tyr Gly Arg Thr Trp Gln Pro Tyr Gln 
                165                 170                 175     


Tyr Tyr Ala Thr Asp Cys Leu Asp Ala Phe His Met Asp Pro Lys Ser 
            180                 185                 190         


Val Lys Asp Leu Ser Gln His Thr Val Leu Glu Ile Ile Cys Thr Glu 
        195                 200                 205             


Glu Tyr Ser Thr Gly Tyr Thr Thr Asn Ser Lys Ile Ile His Phe Glu 
    210                 215                 220                 


Ile Lys Asp Arg Phe Ala Phe Phe Ala Gly Pro Arg Leu Arg Asn Met 
225                 230                 235                 240 


Ala Ser Leu Tyr Gly Gln Leu Asp Thr Thr Lys Lys Leu Arg Asp Phe 
                245                 250                 255     


Phe Thr Val Thr Asp Leu Arg Ile Arg Leu Leu Arg Pro Ala Val Gly 
            260                 265                 270         


Glu Ile Phe Val Asp Glu Leu His Leu Ala Arg Tyr Phe Tyr Ala Ile 
        275                 280                 285             


Ser Asp Ile Lys Val Arg Gly Arg Cys Lys Cys Asn Leu His Ala Thr 
    290                 295                 300                 


Val Cys Val Tyr Asp Asn Ser Lys Leu Thr Cys Glu Cys Glu His Asn 
305                 310                 315                 320 


Thr Thr Gly Pro Asp Cys Gly Lys Cys Lys Lys Asn Tyr Gln Gly Arg 
                325                 330                 335     


Pro Trp Ser Pro Gly Ser Tyr Leu Pro Ile Pro Lys Gly Thr Ala Asn 
            340                 345                 350         


Thr Cys Ile Pro Ser Ile Ser Ser Ile Gly Asn Cys Glu Cys Phe Gly 
        355                 360                 365             


His Ser Asn Arg Cys Ser Tyr Ile Asp Leu Leu Asn Thr Val Ile Cys 
    370                 375                 380                 


Val Ser Cys Lys His Asn Thr Arg Gly Gln His Cys Glu Leu Cys Arg 
385                 390                 395                 400 


Leu Gly Tyr Phe Arg Asn Ala Ser Ala Gln Leu Asp Asp Glu Asn Val 
                405                 410                 415     


Cys Ile Ala Asn Val Cys Asp Asn Glu Leu Leu His Cys Gln Asn Gly 
            420                 425                 430         


Gly Thr Cys His Asn Asn Val Arg Cys Leu Cys Pro Ala Ala Tyr Thr 
        435                 440                 445             


Gly Ile Leu Cys Glu Lys Leu Arg Cys Glu Glu Ala Gly Ser Cys Gly 
    450                 455                 460                 


Ser Asp Ser Gly Gln Gly Ala Pro Pro His Gly Ser Pro Ala Leu Leu 
465                 470                 475                 480 


Leu Leu Thr Thr Leu Leu Gly Thr Ala Ser Pro Leu Val Phe 
                485                 490                 


<210>  9641
<211>  422
<212>  PRT
<213>  Homo Sapiens

<400>  9641

Met Leu His Leu Leu Ala Leu Phe Leu His Cys Leu Pro Leu Ala Ser 
1               5                   10                  15      


Gly Asp Tyr Asp Ile Cys Lys Ser Trp Val Thr Thr Asp Glu Gly Pro 
            20                  25                  30          


Thr Trp Glu Phe Tyr Ala Cys Gln Pro Lys Val Met Arg Leu Lys Asp 
        35                  40                  45              


Tyr Val Lys Val Lys Val Glu Pro Ser Gly Ile Thr Cys Gly Asp Pro 
    50                  55                  60                  


Pro Glu Arg Phe Cys Ser His Glu Asn Pro Tyr Leu Cys Ser Asn Glu 
65                  70                  75                  80  


Cys Asp Ala Ser Asn Pro Asp Leu Ala His Pro Pro Arg Leu Met Phe 
                85                  90                  95      


Asp Lys Glu Glu Glu Gly Leu Ala Thr Tyr Trp Gln Ser Ile Thr Trp 
            100                 105                 110         


Ser Arg Tyr Pro Ser Pro Leu Glu Ala Asn Ile Thr Leu Ser Trp Asn 
        115                 120                 125             


Lys Thr Val Glu Leu Thr Asp Asp Val Val Met Thr Phe Glu Tyr Gly 
    130                 135                 140                 


Arg Pro Thr Val Met Val Leu Glu Lys Ser Leu Asp Asn Gly Arg Thr 
145                 150                 155                 160 


Trp Gln Pro Tyr Gln Phe Tyr Ala Glu Asp Cys Met Glu Ala Phe Gly 
                165                 170                 175     


Met Ser Ala Arg Arg Ala Arg Asp Met Ser Ser Ser Ser Ala His Arg 
            180                 185                 190         


Val Leu Cys Thr Glu Glu Tyr Ser Arg Trp Ala Gly Ser Lys Lys Glu 
        195                 200                 205             


Lys His Val Arg Phe Glu Val Arg Asp Arg Phe Ala Ile Phe Ala Gly 
    210                 215                 220                 


Pro Asp Leu Arg Asn Met Asp Asn Leu Tyr Thr Arg Leu Glu Ser Ala 
225                 230                 235                 240 


Lys Gly Leu Lys Glu Phe Phe Thr Leu Thr Asp Leu Arg Met Arg Leu 
                245                 250                 255     


Leu Arg Pro Ala Leu Gly Gly Thr Tyr Val Gln Arg Glu Asn Leu Tyr 
            260                 265                 270         


Lys Tyr Phe Tyr Ala Ile Ser Asn Ile Glu Val Ile Gly Arg Cys Lys 
        275                 280                 285             


Cys Asn Leu His Ala Asn Leu Cys Ser Met Arg Glu Gly Ser Leu Gln 
    290                 295                 300                 


Cys Glu Cys Glu His Asn Thr Thr Gly Pro Asp Cys Gly Lys Cys Lys 
305                 310                 315                 320 


Lys Asn Phe Arg Thr Arg Ser Trp Arg Ala Gly Ser Tyr Leu Pro Leu 
                325                 330                 335     


Pro His Gly Ser Pro Asn Ala Cys Ala Thr Ala Gly Ser Phe Gly Thr 
            340                 345                 350         


Leu Gln Thr Pro Pro Pro Gly Arg Ser Pro Ser Ala Leu Arg Gly Ser 
        355                 360                 365             


Arg Arg Gly Leu Ala Asn Val Lys Glu Pro Ala Gly Ser Arg Pro Gln 
    370                 375                 380                 


Ile Ser Glu Met Leu Leu Gly Cys Thr Val Thr Leu His Gln Gly Ser 
385                 390                 395                 400 


Val Gly Pro His Ile Pro Pro Lys Leu Ser Leu Pro Asp Pro Gly Gly 
                405                 410                 415     


Pro Trp Leu Gly Ser Gln 
            420         


<210>  9642
<211>  530
<212>  PRT
<213>  Homo Sapiens

<400>  9642

Met Leu His Leu Leu Ala Leu Phe Leu His Cys Leu Pro Leu Ala Ser 
1               5                   10                  15      


Gly Asp Tyr Asp Ile Cys Lys Ser Trp Val Thr Thr Asp Glu Gly Pro 
            20                  25                  30          


Thr Trp Glu Phe Tyr Ala Cys Gln Pro Lys Val Met Arg Leu Lys Asp 
        35                  40                  45              


Tyr Val Lys Val Lys Val Glu Pro Ser Gly Ile Thr Cys Gly Asp Pro 
    50                  55                  60                  


Pro Glu Arg Phe Cys Ser His Glu Asn Pro Tyr Leu Cys Ser Asn Glu 
65                  70                  75                  80  


Cys Asp Ala Ser Asn Pro Asp Leu Ala His Pro Pro Arg Leu Met Phe 
                85                  90                  95      


Asp Lys Glu Glu Glu Gly Leu Ala Thr Tyr Trp Gln Ser Ile Thr Trp 
            100                 105                 110         


Ser Arg Tyr Pro Ser Pro Leu Glu Ala Asn Ile Thr Leu Ser Trp Asn 
        115                 120                 125             


Lys Thr Val Glu Leu Thr Asp Asp Val Val Met Thr Phe Glu Tyr Gly 
    130                 135                 140                 


Arg Pro Thr Val Met Val Leu Glu Lys Ser Leu Asp Asn Gly Arg Thr 
145                 150                 155                 160 


Trp Gln Pro Tyr Gln Phe Tyr Ala Glu Asp Cys Met Glu Ala Phe Gly 
                165                 170                 175     


Met Ser Ala Arg Arg Ala Arg Asp Met Ser Ser Ser Ser Ala His Arg 
            180                 185                 190         


Val Leu Cys Thr Glu Glu Tyr Ser Arg Trp Ala Gly Ser Lys Lys Glu 
        195                 200                 205             


Lys His Val Arg Phe Glu Val Arg Asp Arg Phe Ala Ile Phe Ala Gly 
    210                 215                 220                 


Pro Asp Leu Arg Asn Met Asp Asn Leu Tyr Thr Arg Leu Glu Ser Ala 
225                 230                 235                 240 


Lys Gly Leu Lys Glu Phe Phe Thr Leu Thr Asp Leu Arg Met Arg Leu 
                245                 250                 255     


Leu Arg Pro Ala Leu Gly Gly Thr Tyr Val Gln Arg Glu Asn Leu Tyr 
            260                 265                 270         


Lys Tyr Phe Tyr Ala Ile Ser Asn Ile Glu Val Ile Gly Arg Cys Lys 
        275                 280                 285             


Cys Asn Leu His Ala Asn Leu Cys Ser Met Arg Glu Gly Ser Leu Gln 
    290                 295                 300                 


Cys Glu Cys Glu His Asn Thr Thr Gly Pro Asp Cys Gly Lys Cys Lys 
305                 310                 315                 320 


Lys Asn Phe Arg Thr Arg Ser Trp Arg Ala Gly Ser Tyr Leu Pro Leu 
                325                 330                 335     


Pro His Gly Ser Pro Asn Ala Cys Ala Thr Ala Gly Ser Phe Gly Asn 
            340                 345                 350         


Cys Glu Cys Tyr Gly His Ser Asn Arg Cys Ser Tyr Ile Asp Phe Leu 
        355                 360                 365             


Asn Val Val Thr Cys Val Ser Cys Lys His Asn Thr Arg Gly Gln His 
    370                 375                 380                 


Cys Gln His Cys Arg Leu Gly Tyr Tyr Arg Asn Gly Ser Ala Glu Leu 
385                 390                 395                 400 


Asp Asp Glu Asn Val Cys Ile Glu Cys Asn Cys Asn Gln Ile Gly Ser 
                405                 410                 415     


Val His Asp Arg Cys Asn Glu Thr Gly Phe Cys Glu Cys Arg Glu Gly 
            420                 425                 430         


Ala Ala Gly Pro Lys Cys Asp Asp Cys Leu Pro Thr His Tyr Trp Arg 
        435                 440                 445             


Gln Gly Cys Tyr Pro Asn Val Cys Asp Asp Asp Gln Leu Leu Cys Gln 
    450                 455                 460                 


Asn Gly Gly Thr Cys Leu Gln Asn Gln Arg Cys Ala Cys Pro Arg Gly 
465                 470                 475                 480 


Tyr Thr Gly Val Arg Cys Glu Gln Pro Arg Cys Asp Pro Ala Asp Asp 
                485                 490                 495     


Asp Gly Gly Leu Asp Cys Asp Arg Ala Pro Gly Ala Ala Pro Arg Pro 
            500                 505                 510         


Ala Thr Leu Leu Gly Cys Leu Leu Leu Leu Gly Leu Ala Ala Arg Leu 
        515                 520                 525             


Gly Arg 
    530 


<210>  9643
<211>  170
<212>  PRT
<213>  Homo Sapiens

<400>  9643

Met Met Ala Gly Met Lys Ile Gln Leu Val Cys Met Leu Leu Leu Ala 
1               5                   10                  15      


Phe Ser Ser Trp Ser Leu Cys Ser Asp Ser Glu Glu Glu Met Lys Ala 
            20                  25                  30          


Leu Glu Ala Asp Phe Leu Thr Asn Met His Thr Ser Lys Ile Ser Lys 
        35                  40                  45              


Ala His Val Pro Ser Trp Lys Met Thr Leu Leu Asn Val Cys Ser Leu 
    50                  55                  60                  


Val Asn Asn Leu Asn Ser Pro Ala Glu Glu Thr Gly Glu Val His Glu 
65                  70                  75                  80  


Glu Glu Leu Val Ala Arg Arg Lys Leu Pro Thr Ala Leu Asp Gly Phe 
                85                  90                  95      


Ser Leu Glu Ala Met Leu Thr Ile Tyr Gln Leu His Lys Ile Cys His 
            100                 105                 110         


Ser Arg Ala Phe Gln His Trp Glu Leu Ile Gln Glu Asp Ile Leu Asp 
        115                 120                 125             


Thr Gly Asn Asp Lys Asn Gly Lys Glu Glu Val Ile Lys Arg Lys Ile 
    130                 135                 140                 


Pro Tyr Ile Leu Lys Arg Gln Leu Tyr Glu Asn Lys Pro Arg Arg Pro 
145                 150                 155                 160 


Tyr Ile Leu Lys Arg Asp Ser Tyr Tyr Tyr 
                165                 170 


<210>  9644
<211>  95
<212>  PRT
<213>  Homo Sapiens

<400>  9644

Met Met Ala Gly Met Lys Ile Gln Leu Val Cys Met Leu Leu Leu Ala 
1               5                   10                  15      


Phe Ser Ser Trp Ser Leu Cys Ser Asp Ser Glu Glu Glu Met Lys Ala 
            20                  25                  30          


Leu Glu Ala Asp Phe Leu Thr Asn Met His Thr Ser Lys Leu Ile Gln 
        35                  40                  45              


Glu Asp Ile Leu Asp Thr Gly Asn Asp Lys Asn Gly Lys Glu Glu Val 
    50                  55                  60                  


Ile Lys Arg Lys Ile Pro Tyr Ile Leu Lys Arg Gln Leu Tyr Glu Asn 
65                  70                  75                  80  


Lys Pro Arg Arg Pro Tyr Ile Leu Lys Arg Asp Ser Tyr Tyr Tyr 
                85                  90                  95  


<210>  9645
<211>  103
<212>  PRT
<213>  Homo Sapiens

<400>  9645

Met Gly Ile Trp Gln Arg Leu Leu Leu Phe Gly Gly Val Ser Leu Arg 
1               5                   10                  15      


Ala Gly Gly Gly Ala Thr Ala Pro Leu Gly Gly Ser Arg Ala Met Val 
            20                  25                  30          


Cys Gly Arg Gln Leu Ser Gly Ala Gly Ser Glu Thr Leu Lys Gln Arg 
        35                  40                  45              


Arg Thr Gln Ile Met Ser Arg Gly Leu Pro Lys Gln Lys Pro Ile Glu 
    50                  55                  60                  


Gly Val Lys Gln Val Ile Val Val Ala Ser Gly Lys Gly Gly Val Gly 
65                  70                  75                  80  


Lys Ser Thr Thr Ala Val Glu Thr Gly Phe His Arg Val Asn Gln Asp 
                85                  90                  95      


Gly Leu His Leu Leu Ile Ser 
            100             


<210>  9646
<211>  319
<212>  PRT
<213>  Homo Sapiens

<400>  9646

Met Gly Ile Trp Gln Arg Leu Leu Leu Phe Gly Gly Val Ser Leu Arg 
1               5                   10                  15      


Ala Gly Gly Gly Ala Thr Ala Pro Leu Gly Gly Ser Arg Ala Met Val 
            20                  25                  30          


Cys Gly Arg Gln Leu Ser Gly Ala Gly Ser Glu Thr Leu Lys Gln Arg 
        35                  40                  45              


Arg Thr Gln Ile Met Ser Arg Gly Leu Pro Lys Gln Lys Pro Ile Glu 
    50                  55                  60                  


Gly Val Lys Gln Val Ile Val Val Ala Ser Gly Lys Gly Gly Val Gly 
65                  70                  75                  80  


Lys Ser Thr Thr Ala Val Asn Leu Ala Leu Ala Leu Ala Ala Asn Asp 
                85                  90                  95      


Ser Ser Lys Ala Ile Gly Leu Leu Asp Val Asp Val Tyr Gly Pro Ser 
            100                 105                 110         


Val Pro Lys Met Met Asn Leu Lys Gly Asn Pro Glu Leu Ser Gln Ser 
        115                 120                 125             


Asn Leu Met Arg Pro Leu Leu Asn Tyr Gly Ile Ala Cys Met Ser Met 
    130                 135                 140                 


Gly Phe Leu Val Glu Glu Ser Glu Pro Val Val Trp Arg Gly Leu Met 
145                 150                 155                 160 


Val Met Ser Ala Ile Glu Lys Leu Leu Arg Gln Val Asp Trp Gly Gln 
                165                 170                 175     


Leu Asp Tyr Leu Val Val Asp Met Pro Pro Gly Thr Gly Asp Val Gln 
            180                 185                 190         


Leu Ser Val Ser Gln Asn Ile Pro Ile Thr Gly Ala Val Ile Val Ser 
        195                 200                 205             


Thr Pro Gln Asp Ile Ala Leu Met Asp Ala His Lys Gly Ala Glu Met 
    210                 215                 220                 


Phe Arg Arg Val His Val Pro Val Leu Gly Leu Val Gln Asn Met Ser 
225                 230                 235                 240 


Val Phe Gln Cys Pro Lys Cys Lys His Lys Thr His Ile Phe Gly Ala 
                245                 250                 255     


Asp Gly Ala Arg Lys Leu Ala Gln Thr Leu Gly Leu Glu Val Leu Gly 
            260                 265                 270         


Asp Ile Pro Leu His Leu Asn Ile Arg Glu Ala Ser Asp Thr Gly Gln 
        275                 280                 285             


Pro Ile Val Phe Ser Gln Pro Glu Ser Asp Glu Ala Lys Ala Tyr Leu 
    290                 295                 300                 


Arg Ile Ala Val Glu Val Val Arg Arg Leu Pro Ser Pro Ser Glu 
305                 310                 315                 


<210>  9647
<211>  173
<212>  PRT
<213>  Homo Sapiens

<400>  9647

Met Gly Ile Trp Gln Arg Leu Leu Leu Phe Gly Gly Val Ser Leu Arg 
1               5                   10                  15      


Ala Gly Gly Gly Ala Thr Ala Pro Leu Gly Gly Ser Arg Ala Met Val 
            20                  25                  30          


Cys Gly Arg Gln Leu Ser Gly Ala Gly Ser Glu Thr Leu Lys Gln Arg 
        35                  40                  45              


Arg Thr Gln Ile Met Ser Arg Gly Leu Pro Lys Gln Lys Pro Ile Glu 
    50                  55                  60                  


Gly Val Lys Gln Val Ile Val Val Ala Ser Gly Lys Gly Gly Val Gly 
65                  70                  75                  80  


Lys Ser Thr Thr Ala Val Asn Leu Ala Leu Ala Leu Ala Ala Asn Asp 
                85                  90                  95      


Ser Ser Lys Ala Ile Gly Leu Leu Asp Val Asp Val Tyr Gly Pro Ser 
            100                 105                 110         


Val Pro Lys Met Met Asn Leu Lys Gly Asn Pro Glu Leu Ser Gln Ser 
        115                 120                 125             


Asn Leu Met Arg Pro Leu Leu Asn Tyr Gly Ile Ala Cys Met Ser Met 
    130                 135                 140                 


Gly Phe Leu Val Glu Glu Ser Glu Pro Val Val Trp Arg Gly Leu Met 
145                 150                 155                 160 


Val Met Ser Ala Ile Glu Lys Leu Leu Arg Gln Val Leu 
                165                 170             


<210>  9648
<211>  167
<212>  PRT
<213>  Homo Sapiens

<400>  9648

Met Gly Ile Trp Gln Arg Leu Leu Leu Phe Gly Gly Val Ser Leu Arg 
1               5                   10                  15      


Ala Gly Gly Gly Ala Thr Ala Pro Leu Gly Gly Ser Arg Ala Met Val 
            20                  25                  30          


Cys Gly Arg Gln Leu Ser Gly Ala Gly Ser Glu Thr Leu Lys Gln Arg 
        35                  40                  45              


Arg Thr Gln Ile Met Ser Arg Gly Leu Pro Lys Gln Lys Pro Ile Glu 
    50                  55                  60                  


Gly Val Lys Gln Val Ile Val Val Ala Ser Gly Lys Gly Gly Val Gly 
65                  70                  75                  80  


Lys Ser Thr Thr Ala Val Asn Leu Ala Leu Ala Leu Ala Ala Asn Asp 
                85                  90                  95      


Ser Val Leu Gly Leu Val Gln Asn Met Ser Val Phe Gln Cys Pro Lys 
            100                 105                 110         


Cys Lys His Lys Thr His Ile Phe Gly Ala Asp Gly Ala Arg Lys Leu 
        115                 120                 125             


Ala Gln Thr Leu Gly Leu Glu Val Leu Gly Asp Ile Pro Leu His Leu 
    130                 135                 140                 


Asn Ile Arg Glu Ala Ser Asp Thr Gly Gln Pro Ile Val Phe Ser Gln 
145                 150                 155                 160 


Pro Glu Ser Asp Glu Ala Lys 
                165         


<210>  9649
<211>  54
<212>  PRT
<213>  Homo Sapiens

<400>  9649

Met Met Arg Ile Glu Val Lys Val Lys Met Met Leu Ser Gly Ala Gly 
1               5                   10                  15      


Ser Glu Thr Leu Lys Gln Arg Arg Thr Gln Ile Met Ser Arg Gly Leu 
            20                  25                  30          


Pro Lys Gln Lys Pro Ile Glu Gly Val Lys Gln Val Ile Val Val Ala 
        35                  40                  45              


Ser Gly Lys Gly Gly Val 
    50                  


<210>  9650
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  9650

Met Ser Arg Gly Leu Pro Lys Gln Lys Pro Ile Glu Gly Val Lys Gln 
1               5                   10                  15      


Val Ile Val Val Ala Ser Gly Lys Gly Gly Val Gly Lys Ser Thr Thr 
            20                  25                  30          


Ala Val Asn Leu Ala Leu Ala Leu Ala Ala Asn Asp Ser Ser Lys Ala 
        35                  40                  45              


Ile Gly Leu Leu Asp Val Asp Val Tyr Gly Pro Ser Val Pro Lys Met 
    50                  55                  60                  


Met Asn Leu Lys Gly Asn Pro Glu Leu Ser Gln Ser Asn Leu Met Arg 
65                  70                  75                  80  


Pro Leu Leu Asn Tyr Gly Ile Ala Cys Met Ser Met Gly Phe Leu Val 
                85                  90                  95      


Glu Glu Ser Glu Pro Val Val Trp Arg Gly Leu Met Val Met Ser Ala 
            100                 105                 110         


Ile Glu Lys Leu Leu Arg Gln Val Asp Trp Gly Gln Leu Asp Tyr Leu 
        115                 120                 125             


Val Val Asp Met Pro 
    130             


<210>  9651
<211>  130
<212>  PRT
<213>  Homo Sapiens

<400>  9651

Val Ser Leu Arg Ala Gly Gly Gly Ala Thr Ala Pro Leu Gly Gly Ser 
1               5                   10                  15      


Arg Ala Met Val Cys Gly Arg Gln Leu Ser Gly Ala Gly Ser Glu Thr 
            20                  25                  30          


Leu Lys Gln Arg Arg Thr Gln Ile Met Ser Arg Gly Leu Pro Lys Gln 
        35                  40                  45              


Lys Pro Ile Glu Gly Val Lys Gln Val Ile Val Val Ala Ser Gly Lys 
    50                  55                  60                  


Gly Gly Val Gly Lys Ser Thr Thr Ala Val Asn Leu Ala Leu Ala Leu 
65                  70                  75                  80  


Ala Ala Asn Asp Ser Ser Lys Ala Ile Gly Leu Leu Asp Val Asp Val 
                85                  90                  95      


Tyr Gly Pro Ser Val Pro Lys Met Met Asn Leu Lys Gly Asn Pro Glu 
            100                 105                 110         


Leu Ser Gln Ser Ile Ser Gln Arg Cys Cys Arg Ser Cys Ser Arg Pro 
        115                 120                 125             


Pro Gln 
    130 


<210>  9652
<211>  111
<212>  PRT
<213>  Homo Sapiens

<400>  9652

Met Pro Pro Ser Gly Pro Arg Gly Thr Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Arg Ala Val Leu Ala Val Pro Leu Glu Arg Gly 
            20                  25                  30          


Ala Pro Asn Lys Glu Glu Thr Pro Ala Thr Glu Ser Pro Asp Thr Gly 
        35                  40                  45              


Leu Tyr Tyr His Arg Tyr Leu Gln Glu Val Ile Asp Val Leu Glu Thr 
    50                  55                  60                  


Asp Gly His Phe Arg Glu Lys Leu Gln Ala Ala Asn Ala Glu Asp Ile 
65                  70                  75                  80  


Lys Ser Gly Lys Leu Ser Arg Glu Leu Asp Phe Val Ser His His Val 
                85                  90                  95      


Arg Thr Lys Leu Asp Glu Leu Lys Arg Gln Glu Val Ser Arg Leu 
            100                 105                 110     


<210>  9653
<211>  124
<212>  PRT
<213>  Homo Sapiens

<400>  9653

Met Pro Pro Ser Gly Pro Arg Gly Thr Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Arg Ala Val Leu Ala Val Pro Leu Glu Arg Gly 
            20                  25                  30          


Ala Pro Asn Lys Glu Glu Thr Pro Ala Thr Glu Ser Pro Asp Thr Gly 
        35                  40                  45              


Leu Tyr Tyr His Arg Tyr Leu Gln Glu Val Ile Asp Val Leu Glu Thr 
    50                  55                  60                  


Asp Gly His Phe Arg Glu Lys Leu Gln Ala Ala Asn Ala Glu Asp Ile 
65                  70                  75                  80  


Lys Ser Gly Lys Leu Ser Arg Glu Leu Asp Phe Val Ser His His Val 
                85                  90                  95      


Arg Thr Lys Leu Asp Glu Leu Lys Arg Gln Glu Val Ser Arg Leu Arg 
            100                 105                 110         


Met Leu Leu Lys Ala Lys Met Asp Ala Glu Gln Asp 
        115                 120                 


<210>  9654
<211>  268
<212>  PRT
<213>  Homo Sapiens

<400>  9654

Met Pro Pro Ser Gly Pro Arg Gly Thr Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Arg Ala Val Leu Ala Val Pro Leu Glu Arg Gly 
            20                  25                  30          


Ala Pro Asn Lys Glu Glu Thr Pro Ala Thr Glu Ser Pro Asp Thr Gly 
        35                  40                  45              


Leu Tyr Tyr His Arg Tyr Leu Gln Glu Val Ile Asp Val Leu Glu Thr 
    50                  55                  60                  


Asp Gly His Phe Arg Glu Lys Leu Gln Ala Ala Asn Ala Glu Asp Ile 
65                  70                  75                  80  


Lys Ser Gly Lys Leu Ser Arg Glu Leu Asp Phe Val Ser His His Val 
                85                  90                  95      


Arg Thr Lys Leu Asp Glu Leu Lys Arg Gln Glu Val Ser Arg Leu Arg 
            100                 105                 110         


Met Leu Leu Lys Ala Lys Met Asp Ala Glu Gln Asp Pro Asn Val Gln 
        115                 120                 125             


Val Asp His Leu Asn Leu Leu Lys Gln Phe Glu His Leu Asp Pro Gln 
    130                 135                 140                 


Asn Gln His Thr Phe Glu Ala Arg Asp Leu Glu Leu Leu Ile Gln Thr 
145                 150                 155                 160 


Ala Thr Arg Asp Leu Ala Gln Tyr Asp Ala Ala His His Glu Glu Phe 
                165                 170                 175     


Lys Arg Tyr Glu Met Leu Lys Glu His Glu Arg Arg Arg Tyr Leu Glu 
            180                 185                 190         


Ser Leu Gly Glu Glu Gln Arg Lys Glu Ala Glu Arg Lys Leu Glu Glu 
        195                 200                 205             


Gln Gln Arg Arg His Arg Glu His Pro Lys Val Asn Val Pro Gly Ser 
    210                 215                 220                 


Gln Ala Gln Leu Lys Glu Val Trp Glu Glu Leu Asp Gly Leu Asp Pro 
225                 230                 235                 240 


Asn Arg Asp Leu Thr His Pro Val Leu Gly Pro Leu Arg Tyr Leu Ala 
                245                 250                 255     


Ile Leu Phe Pro Ser Asp Ile Asn Ser Asp Gly Val 
            260                 265             


<210>  9655
<211>  461
<212>  PRT
<213>  Homo Sapiens

<400>  9655

Met Pro Pro Ser Gly Pro Arg Gly Thr Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Arg Ala Val Leu Ala Val Pro Leu Glu Arg Gly 
            20                  25                  30          


Ala Pro Asn Lys Glu Glu Thr Pro Ala Thr Glu Ser Pro Asp Thr Gly 
        35                  40                  45              


Leu Tyr Tyr His Arg Tyr Leu Gln Glu Val Ile Asp Val Leu Glu Thr 
    50                  55                  60                  


Asp Gly His Phe Arg Glu Lys Leu Gln Ala Ala Asn Ala Glu Asp Ile 
65                  70                  75                  80  


Lys Ser Gly Lys Leu Ser Arg Glu Leu Asp Phe Val Ser His His Val 
                85                  90                  95      


Arg Thr Lys Leu Asp Glu Leu Lys Arg Gln Glu Val Ser Arg Leu Arg 
            100                 105                 110         


Met Leu Leu Lys Ala Lys Met Asp Ala Glu Gln Asp Pro Asn Val Gln 
        115                 120                 125             


Val Asp His Leu Asn Leu Leu Lys Gln Phe Glu His Leu Asp Pro Gln 
    130                 135                 140                 


Asn Gln His Thr Phe Glu Ala Arg Asp Leu Glu Leu Leu Ile Gln Thr 
145                 150                 155                 160 


Ala Thr Arg Asp Leu Ala Gln Tyr Asp Ala Ala His His Glu Glu Phe 
                165                 170                 175     


Lys Arg Tyr Glu Met Leu Lys Glu His Glu Arg Arg Arg Tyr Leu Glu 
            180                 185                 190         


Ser Leu Gly Glu Glu Gln Arg Lys Glu Ala Glu Arg Lys Leu Glu Glu 
        195                 200                 205             


Gln Gln Arg Arg His Arg Glu His Pro Lys Val Asn Val Pro Gly Ser 
    210                 215                 220                 


Gln Ala Gln Leu Lys Glu Val Trp Glu Glu Leu Asp Gly Leu Asp Pro 
225                 230                 235                 240 


Asn Arg Phe Asn Pro Lys Thr Phe Phe Ile Leu His Asp Ile Asn Ser 
                245                 250                 255     


Asp Gly Val Leu Asp Glu Gln Glu Leu Glu Ala Leu Phe Thr Lys Glu 
            260                 265                 270         


Leu Glu Lys Val Tyr Asp Pro Lys Asn Glu Glu Asp Asp Met Arg Glu 
        275                 280                 285             


Met Glu Glu Glu Arg Leu Arg Met Arg Glu His Val Met Lys Asn Val 
    290                 295                 300                 


Asp Thr Asn Gln Asp Arg Leu Val Thr Leu Glu Glu Phe Leu Ala Ser 
305                 310                 315                 320 


Thr Gln Arg Lys Glu Phe Gly Asp Thr Gly Glu Gly Trp Glu Thr Val 
                325                 330                 335     


Glu Met His Pro Ala Tyr Thr Glu Glu Glu Leu Arg Arg Phe Glu Glu 
            340                 345                 350         


Glu Leu Ala Ala Arg Glu Ala Glu Leu Asn Ala Lys Ala Gln Arg Leu 
        355                 360                 365             


Ser Gln Glu Thr Glu Ala Leu Gly Arg Ser Gln Gly Arg Leu Glu Ala 
    370                 375                 380                 


Gln Lys Arg Glu Leu Gln Gln Ala Val Leu His Met Glu Gln Arg Lys 
385                 390                 395                 400 


Gln Gln Gln Gln Gln Gln Gln Gly His Lys Ala Pro Ala Ala His Pro 
                405                 410                 415     


Glu Gly Gln Leu Lys Phe His Pro Asp Thr Asp Asp Val Pro Val Pro 
            420                 425                 430         


Ala Pro Ala Gly Asp Gln Lys Glu Val Asp Thr Ser Glu Lys Lys Leu 
        435                 440                 445             


Leu Glu Arg Leu Pro Glu Val Glu Val Pro Gln His Leu 
    450                 455                 460     


<210>  9656
<211>  461
<212>  PRT
<213>  Homo Sapiens

<400>  9656

Met Pro Pro Ser Gly Pro Arg Gly Thr Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Arg Ala Val Leu Ala Val Pro Leu Glu Arg Gly 
            20                  25                  30          


Ala Pro Asn Lys Glu Glu Thr Pro Ala Thr Glu Ser Pro Asp Thr Gly 
        35                  40                  45              


Leu Tyr Tyr His Arg Tyr Leu Gln Glu Val Ile Asp Val Leu Glu Thr 
    50                  55                  60                  


Asp Gly His Phe Arg Glu Lys Leu Gln Ala Ala Asn Ala Glu Asp Ile 
65                  70                  75                  80  


Lys Ser Gly Lys Leu Ser Arg Glu Leu Asp Phe Val Ser His His Val 
                85                  90                  95      


Arg Thr Lys Leu Asp Glu Leu Lys Arg Gln Glu Val Ser Arg Leu Arg 
            100                 105                 110         


Met Leu Leu Lys Ala Lys Met Asp Ala Glu Gln Asp Pro Asn Val Gln 
        115                 120                 125             


Val Asp His Leu Asn Leu Leu Lys Gln Phe Glu His Leu Asp Pro Gln 
    130                 135                 140                 


Asn Gln His Thr Phe Glu Ala Arg Asp Leu Glu Leu Leu Ile Gln Thr 
145                 150                 155                 160 


Ala Thr Arg Asp Leu Ala Gln Tyr Asp Ala Ala His His Glu Glu Phe 
                165                 170                 175     


Lys Arg Tyr Glu Met Leu Lys Glu His Glu Arg Arg Arg Tyr Leu Glu 
            180                 185                 190         


Ser Leu Gly Glu Glu Gln Arg Lys Glu Ala Glu Arg Lys Leu Glu Glu 
        195                 200                 205             


Gln Gln Arg Arg His Arg Glu His Pro Lys Val Asn Val Pro Gly Ser 
    210                 215                 220                 


Gln Ala Gln Leu Lys Glu Val Trp Glu Glu Leu Asp Gly Leu Asp Pro 
225                 230                 235                 240 


Asn Arg Phe Asn Pro Lys Thr Phe Phe Ile Leu His Asp Ile Asn Ser 
                245                 250                 255     


Asp Gly Val Leu Asp Glu Gln Glu Leu Glu Ala Leu Phe Thr Lys Glu 
            260                 265                 270         


Leu Glu Lys Val Tyr Asp Pro Lys Asn Glu Glu Asp Asp Met Arg Glu 
        275                 280                 285             


Met Glu Glu Glu Arg Leu Arg Met Arg Glu His Val Met Lys Asn Val 
    290                 295                 300                 


Asp Thr Asn Gln Asp Arg Leu Val Thr Leu Glu Glu Phe Leu Ala Ser 
305                 310                 315                 320 


Thr Gln Arg Lys Glu Phe Gly Asp Thr Gly Glu Gly Trp Glu Thr Val 
                325                 330                 335     


Glu Met His Pro Ala Tyr Thr Glu Glu Glu Leu Arg Arg Phe Glu Glu 
            340                 345                 350         


Glu Leu Ala Ala Arg Glu Ala Glu Leu Asn Ala Lys Ala Gln Arg Leu 
        355                 360                 365             


Ser Gln Glu Thr Glu Ala Leu Gly Arg Ser Gln Gly Arg Leu Glu Ala 
    370                 375                 380                 


Gln Lys Arg Glu Leu Gln Gln Ala Val Leu His Met Glu Gln Arg Lys 
385                 390                 395                 400 


Gln Gln Gln Gln Gln Gln Gln Gly His Lys Ala Pro Ala Ala His Pro 
                405                 410                 415     


Glu Gly Gln Leu Lys Phe His Pro Asp Thr Asp Asp Val Pro Val Pro 
            420                 425                 430         


Ala Pro Ala Gly Asp Gln Lys Glu Val Asp Thr Ser Glu Lys Lys Leu 
        435                 440                 445             


Leu Glu Arg Leu Pro Glu Val Glu Val Pro Gln His Leu 
    450                 455                 460     


<210>  9657
<211>  75
<212>  PRT
<213>  Homo Sapiens

<400>  9657

Met Pro Pro Ser Gly Pro Arg Gly Thr Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Arg Ala Val Leu Ala Val Pro Leu Glu Arg Gly 
            20                  25                  30          


Ala Pro Asn Lys Glu Glu Thr Pro Ala Thr Glu Ser Pro Val Ser Gly 
        35                  40                  45              


Pro Ala Leu Leu Ser Ser Gln Val Phe Ala Val Val Leu Gln Leu Leu 
    50                  55                  60                  


Gln Thr Pro Val Pro Val Gly Arg Met Leu Gln 
65                  70                  75  


<210>  9658
<211>  295
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9658

Xaa Pro Pro Ser Gly Pro Arg Gly Thr Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Arg Ala Val Leu Ala Val Pro Leu Glu Arg Gly 
            20                  25                  30          


Ala Pro Asn Lys Glu Glu Thr Pro Ala Thr Glu Ser Pro Asp Thr Gly 
        35                  40                  45              


Leu Tyr Tyr His Arg Tyr Leu Gln Glu Val Ile Asp Val Leu Glu Thr 
    50                  55                  60                  


Asp Gly His Phe Arg Glu Lys Leu Gln Ala Ala Asn Ala Glu Asp Ile 
65                  70                  75                  80  


Lys Ser Gly Lys Leu Ser Arg Glu Leu Asp Phe Val Ser His His Val 
                85                  90                  95      


Arg Thr Lys Leu Asp Glu Leu Lys Arg Gln Glu Phe Glu His Leu Asp 
            100                 105                 110         


Pro Gln Asn Gln His Thr Phe Glu Ala Arg Asp Leu Glu Leu Leu Ile 
        115                 120                 125             


Gln Thr Ala Thr Arg Asp Leu Ala Gln Tyr Asp Ala Ala His His Glu 
    130                 135                 140                 


Glu Phe Lys Arg Tyr Glu Met Leu Lys Glu His Glu Arg Arg Arg Tyr 
145                 150                 155                 160 


Leu Glu Ser Leu Gly Glu Glu Gln Arg Lys Glu Ala Glu Arg Lys Leu 
                165                 170                 175     


Glu Glu Gln Gln Arg Arg His Arg Glu His Pro Lys Val Asn Val Pro 
            180                 185                 190         


Gly Ser Gln Ala Gln Leu Lys Glu Val Trp Glu Glu Leu Asp Gly Leu 
        195                 200                 205             


Asp Pro Asn Arg Phe Asn Pro Lys Thr Phe Phe Ile Leu His Asp Ile 
    210                 215                 220                 


Asn Ser Asp Gly Val Leu Asp Glu Gln Glu Leu Glu Ala Leu Phe Thr 
225                 230                 235                 240 


Lys Glu Leu Glu Lys Val Tyr Asp Pro Lys Asn Glu Glu Asp Asp Met 
                245                 250                 255     


Arg Glu Met Glu Glu Glu Arg Leu Arg Met Arg Glu His Val Met Lys 
            260                 265                 270         


Asn Val Asp Thr Asn Gln Asp Arg Leu Val Thr Leu Glu Glu Phe Leu 
        275                 280                 285             


Ala Ser Thr Gln Arg Lys Glu 
    290                 295 


<210>  9659
<211>  34
<212>  PRT
<213>  Homo Sapiens

<400>  9659

Met Arg Trp Arg Thr Ile Leu Leu Gln Tyr Cys Phe Leu Leu Ile Thr 
1               5                   10                  15      


Cys Leu Leu Thr Ala Leu Glu Ala Val Pro Ile Asp Ile Asp Lys Thr 
            20                  25                  30          


Lys Val 
        


<210>  9660
<211>  34
<212>  PRT
<213>  Homo Sapiens

<400>  9660

Met Arg Trp Arg Thr Ile Leu Leu Gln Tyr Cys Phe Leu Leu Ile Thr 
1               5                   10                  15      


Cys Leu Leu Thr Ala Leu Glu Ala Val Pro Ile Asp Ile Asp Lys Thr 
            20                  25                  30          


Lys Val 
        


<210>  9661
<211>  39
<212>  PRT
<213>  Homo Sapiens

<400>  9661

Met Arg Trp Arg Thr Ile Leu Leu Gln Tyr Cys Phe Leu Leu Ile Thr 
1               5                   10                  15      


Cys Leu Leu Thr Ala Leu Glu Ala Val Pro Ile Asp Ile Asp Lys Thr 
            20                  25                  30          


Lys Val Gln Asn Ile His Pro 
        35                  


<210>  9662
<211>  69
<212>  PRT
<213>  Homo Sapiens

<400>  9662

Met Arg Trp Arg Thr Ile Leu Leu Gln Tyr Cys Phe Leu Leu Ile Thr 
1               5                   10                  15      


Cys Leu Leu Thr Ala Leu Glu Ala Val Pro Ile Asp Ile Asp Lys Thr 
            20                  25                  30          


Lys Val Gln Asn Ile His Pro Val Glu Ser Ala Lys Ile Glu Pro Pro 
        35                  40                  45              


Asp Thr Gly Leu Tyr Tyr Asp Glu Tyr Leu Lys Gln Val Ile Asp Val 
    50                  55                  60                  


Leu Glu Thr Asp Lys 
65                  


<210>  9663
<211>  69
<212>  PRT
<213>  Homo Sapiens

<400>  9663

Met Arg Trp Arg Thr Ile Leu Leu Gln Tyr Cys Phe Leu Leu Ile Thr 
1               5                   10                  15      


Cys Leu Leu Thr Ala Leu Glu Ala Val Pro Ile Asp Ile Asp Lys Thr 
            20                  25                  30          


Lys Val Gln Asn Ile His Pro Val Glu Ser Ala Lys Ile Glu Pro Pro 
        35                  40                  45              


Asp Thr Gly Leu Tyr Tyr Asp Glu Tyr Leu Lys Gln Val Ile Asp Val 
    50                  55                  60                  


Leu Glu Thr Asp Lys 
65                  


<210>  9664
<211>  90
<212>  PRT
<213>  Homo Sapiens

<400>  9664

Met Arg Trp Arg Thr Ile Leu Leu Gln Tyr Cys Phe Leu Leu Ile Thr 
1               5                   10                  15      


Cys Leu Leu Thr Ala Leu Glu Ala Val Pro Ile Asp Ile Asp Lys Thr 
            20                  25                  30          


Lys Val Gln Asn Ile His Pro Val Glu Ser Ala Lys Ile Glu Pro Pro 
        35                  40                  45              


Asp Thr Gly Leu Tyr Tyr Asp Glu Tyr Leu Lys Gln Val Ile Asp Val 
    50                  55                  60                  


Leu Glu Thr Asp Lys His Phe Arg Glu Lys Leu Gln Lys Ala Asp Ile 
65                  70                  75                  80  


Glu Glu Ile Lys Ser Gly Arg Leu Ser Lys 
                85                  90  


<210>  9665
<211>  195
<212>  PRT
<213>  Homo Sapiens

<400>  9665

Met Arg Trp Arg Thr Ile Leu Leu Gln Tyr Cys Phe Leu Leu Ile Thr 
1               5                   10                  15      


Cys Leu Leu Thr Ala Leu Glu Ala Val Pro Ile Asp Ile Asp Lys Thr 
            20                  25                  30          


Lys Val Gln Asn Ile His Pro Val Glu Ser Ala Lys Ile Glu Pro Pro 
        35                  40                  45              


Asp Thr Gly Leu Tyr Tyr Asp Glu Tyr Leu Lys Gln Val Ile Asp Val 
    50                  55                  60                  


Leu Glu Thr Asp Lys His Phe Arg Glu Lys Leu Gln Lys Ala Asp Ile 
65                  70                  75                  80  


Glu Glu Ile Lys Ser Gly Arg Leu Ser Lys Glu Leu Asp Leu Val Ser 
                85                  90                  95      


His His Val Arg Thr Lys Leu Asp Glu Leu Lys Arg Gln Glu Val Gly 
            100                 105                 110         


Arg Leu Arg Met Leu Ile Lys Ala Lys Leu Asp Ser Leu Gln Asp Ile 
        115                 120                 125             


Gly Met Asp His Gln Ala Leu Leu Lys Gln Phe Asp His Leu Asn His 
    130                 135                 140                 


Leu Asn Pro Asp Lys Phe Glu Ser Thr Asp Leu Asp Met Leu Ile Lys 
145                 150                 155                 160 


Ala Ala Thr Ser Asp Leu Glu His Tyr Asp Lys Thr Arg His Glu Glu 
                165                 170                 175     


Phe Lys Lys Tyr Glu Met Met Lys Glu His Glu Arg Arg Glu Tyr Leu 
            180                 185                 190         


Lys Thr Leu 
        195 


<210>  9666
<211>  198
<212>  PRT
<213>  Homo Sapiens

<400>  9666

Met Arg Trp Arg Thr Ile Leu Leu Gln Tyr Cys Phe Leu Leu Ile Thr 
1               5                   10                  15      


Cys Leu Leu Thr Ala Leu Glu Ala Val Pro Ile Asp Ile Asp Lys Thr 
            20                  25                  30          


Lys Val Gln Asn Ile His Pro Val Glu Ser Ala Lys Ile Glu Pro Pro 
        35                  40                  45              


Asp Thr Gly Leu Tyr Tyr Asp Glu Tyr Leu Lys Gln Val Ile Asp Val 
    50                  55                  60                  


Leu Glu Thr Asp Lys His Phe Arg Glu Lys Leu Gln Lys Ala Asp Ile 
65                  70                  75                  80  


Glu Glu Ile Lys Ser Gly Arg Leu Ser Lys Glu Leu Asp Leu Val Ser 
                85                  90                  95      


His His Val Arg Thr Lys Leu Asp Glu Leu Lys Arg Gln Glu Val Gly 
            100                 105                 110         


Arg Leu Arg Met Leu Ile Lys Ala Lys Leu Asp Ser Leu Gln Asp Ile 
        115                 120                 125             


Gly Met Asp His Gln Ala Leu Leu Lys Gln Phe Asp His Leu Asn His 
    130                 135                 140                 


Leu Asn Pro Asp Lys Phe Glu Ser Thr Asp Leu Asp Met Leu Ile Lys 
145                 150                 155                 160 


Ala Ala Thr Ser Asp Leu Glu His Tyr Asp Lys Thr Arg His Glu Glu 
                165                 170                 175     


Phe Lys Lys Tyr Glu Met Met Lys Glu His Glu Arg Arg Glu Tyr Leu 
            180                 185                 190         


Lys Thr Leu Asn Glu Glu 
        195             


<210>  9667
<211>  420
<212>  PRT
<213>  Homo Sapiens

<400>  9667

Met Arg Trp Arg Thr Ile Leu Leu Gln Tyr Cys Phe Leu Leu Ile Thr 
1               5                   10                  15      


Cys Leu Leu Thr Ala Leu Glu Ala Val Pro Ile Asp Ile Asp Lys Thr 
            20                  25                  30          


Lys Val Gln Asn Ile His Pro Val Glu Ser Ala Lys Ile Glu Pro Pro 
        35                  40                  45              


Asp Thr Gly Leu Tyr Tyr Asp Glu Tyr Leu Lys Gln Val Ile Asp Val 
    50                  55                  60                  


Leu Glu Thr Asp Lys His Phe Arg Glu Lys Leu Gln Lys Ala Asp Ile 
65                  70                  75                  80  


Glu Glu Ile Lys Ser Gly Arg Leu Ser Lys Glu Leu Asp Leu Val Ser 
                85                  90                  95      


His His Val Arg Thr Lys Leu Asp Glu Leu Lys Arg Gln Glu Val Gly 
            100                 105                 110         


Arg Leu Arg Met Leu Ile Lys Ala Lys Leu Asp Ser Leu Gln Asp Ile 
        115                 120                 125             


Gly Met Asp His Gln Ala Leu Leu Lys Gln Phe Asp His Leu Asn His 
    130                 135                 140                 


Leu Asn Pro Asp Lys Phe Glu Ser Thr Asp Leu Asp Met Leu Ile Lys 
145                 150                 155                 160 


Ala Ala Thr Ser Asp Leu Glu His Tyr Asp Lys Thr Arg His Glu Glu 
                165                 170                 175     


Phe Lys Lys Tyr Glu Met Met Lys Glu His Glu Arg Arg Glu Tyr Leu 
            180                 185                 190         


Lys Thr Leu Asn Glu Glu Lys Arg Lys Glu Glu Glu Ser Lys Phe Glu 
        195                 200                 205             


Glu Met Lys Lys Lys His Glu Asn His Pro Lys Val Asn His Pro Gly 
    210                 215                 220                 


Ser Lys Asp Gln Leu Lys Glu Val Trp Glu Glu Thr Asp Gly Leu Asp 
225                 230                 235                 240 


Pro Asn Asp Phe Asp Pro Lys Thr Phe Phe Lys Leu His Asp Val Asn 
                245                 250                 255     


Ser Asp Gly Phe Leu Asp Glu Gln Glu Leu Glu Ala Leu Phe Thr Lys 
            260                 265                 270         


Glu Leu Glu Lys Val Tyr Asp Pro Lys Asn Glu Glu Asp Asp Met Val 
        275                 280                 285             


Glu Met Glu Glu Glu Arg Leu Arg Met Arg Glu His Val Met Asn Glu 
    290                 295                 300                 


Val Asp Thr Asn Lys Asp Arg Leu Val Thr Leu Glu Glu Phe Leu Lys 
305                 310                 315                 320 


Ala Thr Glu Lys Lys Glu Phe Leu Glu Pro Asp Ser Trp Glu Thr Leu 
                325                 330                 335     


Asp Gln Gln Gln Phe Phe Thr Glu Glu Glu Leu Lys Glu Tyr Glu Asn 
            340                 345                 350         


Ile Ile Ala Leu Gln Glu Asn Glu Leu Lys Lys Lys Ala Asp Glu Leu 
        355                 360                 365             


Gln Lys Gln Lys Glu Glu Leu Gln Arg Gln His Asp Gln Leu Glu Ala 
    370                 375                 380                 


Gln Lys Leu Glu Tyr His Gln Val Ile Gln Gln Met Glu Gln Lys Lys 
385                 390                 395                 400 


Leu Gln Gln Gly Ile Pro Pro Ser Gly Pro Ala Gly Glu Leu Lys Phe 
                405                 410                 415     


Glu Pro Arg Val 
            420 


<210>  9668
<211>  390
<212>  PRT
<213>  Homo Sapiens

<400>  9668

Met Arg Trp Arg Thr Ile Leu Leu Gln Tyr Cys Phe Leu Leu Ile Thr 
1               5                   10                  15      


Cys Leu Leu Thr Ala Leu Glu Ala Val Pro Ile Asp Ile Asp Lys Thr 
            20                  25                  30          


Lys Val Gln Asn Ile His Pro Val Glu Ser Ala Lys Ile Glu Pro Pro 
        35                  40                  45              


Asp Thr Gly Leu Tyr Tyr Asp Glu Tyr Leu Lys Gln Val Ile Asp Val 
    50                  55                  60                  


Leu Glu Thr Asp Lys His Phe Arg Glu Lys Leu Gln Lys Ala Asp Ile 
65                  70                  75                  80  


Glu Glu Ile Lys Ser Gly Arg Leu Ser Lys Glu Leu Asp Leu Val Ser 
                85                  90                  95      


His His Val Arg Thr Lys Leu Asp Glu Leu Lys Arg Gln Glu Val Gly 
            100                 105                 110         


Arg Leu Arg Met Leu Ile Lys Ala Lys Leu Asp Ser Leu Gln Asp Ile 
        115                 120                 125             


Gly Met Asp His Gln Ala Leu Leu Lys Gln Phe Asp His Leu Asn His 
    130                 135                 140                 


Leu Asn Pro Asp Lys Phe Glu Ser Thr Asp Leu Asp Met Leu Ile Lys 
145                 150                 155                 160 


Ala Ala Thr Ser Asp Leu Glu His Tyr Asp Lys Thr Arg His Glu Glu 
                165                 170                 175     


Phe Lys Lys Tyr Glu Met Met Lys Glu His Glu Arg Arg Glu Tyr Leu 
            180                 185                 190         


Lys Thr Leu Asn Glu Glu Lys Arg Lys Glu Glu Glu Ser Lys Phe Glu 
        195                 200                 205             


Glu Met Lys Lys Lys His Glu Asn His Pro Lys Val Asn His Pro Gly 
    210                 215                 220                 


Ser Lys Asp Gln Leu Lys Glu Val Trp Glu Glu Thr Asp Gly Leu Asp 
225                 230                 235                 240 


Pro Asn Asp Phe Asp Pro Lys Thr Phe Phe Lys Leu His Asp Val Asn 
                245                 250                 255     


Ser Asp Gly Phe Leu Asp Glu Gln Glu Leu Glu Ala Leu Phe Thr Lys 
            260                 265                 270         


Glu Leu Glu Lys Val Tyr Asp Pro Lys Asn Glu Glu Asp Asp Met Val 
        275                 280                 285             


Glu Met Glu Glu Glu Arg Leu Arg Met Arg Glu His Val Met Asn Glu 
    290                 295                 300                 


Thr Leu Asp Gln Gln Gln Phe Phe Thr Glu Glu Glu Leu Lys Glu Tyr 
305                 310                 315                 320 


Glu Asn Ile Ile Ala Leu Gln Glu Asn Glu Leu Lys Lys Lys Ala Asp 
                325                 330                 335     


Glu Leu Gln Lys Gln Lys Glu Glu Leu Gln Arg Gln His Asp Gln Leu 
            340                 345                 350         


Glu Ala Gln Lys Leu Glu Tyr His Gln Val Ile Gln Gln Met Glu Gln 
        355                 360                 365             


Lys Lys Leu Gln Gln Gly Ile Pro Pro Ser Gly Pro Ala Gly Glu Leu 
    370                 375                 380                 


Lys Phe Glu Pro His Ile 
385                 390 


<210>  9669
<211>  420
<212>  PRT
<213>  Homo Sapiens

<400>  9669

Met Arg Trp Arg Thr Ile Leu Leu Gln Tyr Cys Phe Leu Leu Ile Thr 
1               5                   10                  15      


Cys Leu Leu Thr Ala Leu Glu Ala Val Pro Ile Asp Ile Asp Lys Thr 
            20                  25                  30          


Lys Val Gln Asn Ile His Pro Val Glu Ser Ala Lys Ile Glu Pro Pro 
        35                  40                  45              


Asp Thr Gly Leu Tyr Tyr Asp Glu Tyr Leu Lys Gln Val Ile Asp Val 
    50                  55                  60                  


Leu Glu Thr Asp Lys His Phe Arg Glu Lys Leu Gln Lys Ala Asp Ile 
65                  70                  75                  80  


Glu Glu Ile Lys Ser Gly Arg Leu Ser Lys Glu Leu Asp Leu Val Ser 
                85                  90                  95      


His His Val Arg Thr Lys Leu Asp Glu Leu Lys Arg Gln Glu Val Gly 
            100                 105                 110         


Arg Leu Arg Met Leu Ile Lys Ala Lys Leu Asp Ser Leu Gln Asp Ile 
        115                 120                 125             


Gly Met Asp His Gln Ala Leu Leu Lys Gln Phe Asp His Leu Asn His 
    130                 135                 140                 


Leu Asn Pro Asp Lys Phe Glu Ser Thr Asp Leu Asp Met Leu Ile Lys 
145                 150                 155                 160 


Ala Ala Thr Ser Asp Leu Glu His Tyr Asp Lys Thr Arg His Glu Glu 
                165                 170                 175     


Phe Lys Lys Tyr Glu Met Met Lys Glu His Glu Arg Arg Glu Tyr Leu 
            180                 185                 190         


Lys Thr Leu Asn Glu Glu Lys Arg Lys Glu Glu Glu Ser Lys Phe Glu 
        195                 200                 205             


Glu Met Lys Lys Lys His Glu Asn His Pro Lys Val Asn His Pro Gly 
    210                 215                 220                 


Ser Lys Asp Gln Leu Lys Glu Val Trp Glu Glu Thr Asp Gly Leu Asp 
225                 230                 235                 240 


Pro Asn Asp Phe Asp Pro Lys Thr Phe Phe Lys Leu His Asp Val Asn 
                245                 250                 255     


Ser Asp Gly Phe Leu Asp Glu Gln Glu Leu Glu Ala Leu Phe Thr Lys 
            260                 265                 270         


Glu Leu Glu Lys Val Tyr Asp Pro Lys Asn Glu Glu Asp Asp Met Val 
        275                 280                 285             


Glu Met Glu Glu Glu Arg Leu Arg Met Arg Glu His Val Met Asn Glu 
    290                 295                 300                 


Val Asp Thr Asn Lys Asp Arg Leu Val Thr Leu Glu Glu Phe Leu Lys 
305                 310                 315                 320 


Ala Thr Glu Lys Lys Glu Phe Leu Glu Pro Asp Ser Trp Glu Thr Leu 
                325                 330                 335     


Asp Gln Gln Gln Phe Phe Thr Glu Glu Glu Leu Lys Glu Tyr Glu Asn 
            340                 345                 350         


Ile Ile Ala Leu Gln Glu Asn Glu Leu Lys Lys Lys Ala Asp Glu Leu 
        355                 360                 365             


Gln Lys Gln Lys Glu Glu Leu Gln Arg Gln His Asp Gln Leu Glu Ala 
    370                 375                 380                 


Gln Lys Leu Glu Tyr His Gln Val Ile Gln Gln Met Glu Gln Lys Lys 
385                 390                 395                 400 


Leu Gln Gln Gly Ile Pro Pro Ser Gly Pro Ala Gly Glu Leu Lys Phe 
                405                 410                 415     


Glu Pro His Ile 
            420 


<210>  9670
<211>  338
<212>  PRT
<213>  Homo Sapiens

<400>  9670

Met Arg Trp Arg Thr Ile Leu Leu Gln Tyr Cys Phe Leu Leu Ile Thr 
1               5                   10                  15      


Cys Leu Leu Thr Ala Leu Glu Ala Val Pro Ile Asp Ile Asp Lys Thr 
            20                  25                  30          


Lys Val Gln Asn Ile His Pro Val Glu Ser Ala Lys Ile Glu Pro Pro 
        35                  40                  45              


Asp Thr Gly Leu Tyr Tyr Asp Glu Tyr Leu Lys Gln Val Ile Asp Val 
    50                  55                  60                  


Leu Glu Thr Asp Lys His Phe Arg Glu Lys Leu Gln Lys Ala Asp Ile 
65                  70                  75                  80  


Glu Glu Ile Lys Ser Gly Arg Leu Ser Lys Glu Leu Asp Leu Val Ser 
                85                  90                  95      


His His Val Arg Thr Lys Leu Asp Glu Leu Lys Arg Gln Glu Val Gly 
            100                 105                 110         


Arg Leu Arg Met Leu Ile Lys Ala Lys Leu Asp Ser Leu Gln Asp Ile 
        115                 120                 125             


Gly Met Asp His Gln Ala Leu Leu Lys Gln Phe Asp His Leu Asn His 
    130                 135                 140                 


Leu Asn Pro Asp Lys Phe Glu Ser Thr Asp Leu Asp Met Leu Ile Lys 
145                 150                 155                 160 


Ala Ala Thr Ser Asp Leu Glu His Tyr Asp Lys Thr Arg His Glu Glu 
                165                 170                 175     


Phe Lys Lys Tyr Glu Met Met Lys Glu His Glu Arg Arg Glu Tyr Leu 
            180                 185                 190         


Lys Thr Leu Asn Glu Glu Lys Arg Lys Glu Glu Glu Ser Lys Phe Glu 
        195                 200                 205             


Glu Met Lys Lys Lys His Glu Asn His Pro Lys Val Asn His Pro Gly 
    210                 215                 220                 


Ser Lys Asp Gln Leu Lys Glu Val Trp Glu Glu Thr Asp Gly Leu Asp 
225                 230                 235                 240 


Pro Asn Asp Phe Asp Pro Lys Thr Phe Phe Lys Leu His Asp Val Asn 
                245                 250                 255     


Ser Asp Gly Phe Leu Asp Glu Gln Glu Leu Glu Ala Leu Phe Thr Lys 
            260                 265                 270         


Glu Leu Glu Lys Val Tyr Asp Pro Lys Asn Glu Glu Asp Asp Met Val 
        275                 280                 285             


Glu Met Glu Glu Glu Arg Leu Arg Met Arg Glu His Val Met Asn Glu 
    290                 295                 300                 


Val Asp Thr Asn Lys Asp Arg Leu Val Thr Leu Glu Glu Phe Leu Lys 
305                 310                 315                 320 


Ala Thr Glu Lys Lys Glu Phe Leu Glu Pro Asp Ser Trp Glu Ser Pro 
                325                 330                 335     


Ser Ile 
        


<210>  9671
<211>  420
<212>  PRT
<213>  Homo Sapiens

<400>  9671

Met Arg Trp Arg Thr Ile Leu Leu Gln Tyr Cys Phe Leu Leu Ile Thr 
1               5                   10                  15      


Cys Leu Leu Thr Ala Leu Glu Ala Val Pro Ile Asp Ile Asp Lys Thr 
            20                  25                  30          


Lys Val Gln Asn Ile His Pro Val Glu Ser Ala Lys Ile Glu Pro Pro 
        35                  40                  45              


Asp Thr Gly Leu Tyr Tyr Asp Glu Tyr Leu Lys Gln Val Ile Asp Val 
    50                  55                  60                  


Leu Glu Thr Asp Lys His Phe Arg Glu Lys Leu Gln Lys Ala Asp Ile 
65                  70                  75                  80  


Glu Glu Ile Lys Ser Gly Arg Leu Ser Lys Glu Leu Asp Leu Val Ser 
                85                  90                  95      


His His Val Arg Thr Lys Leu Asp Glu Leu Lys Arg Gln Glu Val Gly 
            100                 105                 110         


Arg Leu Arg Met Leu Ile Lys Ala Lys Leu Asp Ser Leu Gln Asp Ile 
        115                 120                 125             


Gly Met Asp His Gln Ala Leu Leu Lys Gln Phe Asp His Leu Asn His 
    130                 135                 140                 


Leu Asn Pro Asp Lys Phe Glu Ser Thr Asp Leu Asp Met Leu Ile Lys 
145                 150                 155                 160 


Ala Ala Thr Ser Asp Leu Glu His Tyr Asp Lys Thr Arg His Glu Glu 
                165                 170                 175     


Phe Lys Lys Tyr Glu Met Met Lys Glu His Glu Arg Arg Glu Tyr Leu 
            180                 185                 190         


Lys Thr Leu Asn Glu Glu Lys Arg Lys Glu Glu Glu Ser Lys Phe Glu 
        195                 200                 205             


Glu Met Lys Lys Lys His Glu Asn His Pro Lys Val Asn His Pro Gly 
    210                 215                 220                 


Ser Lys Asp Gln Leu Lys Glu Val Trp Glu Glu Thr Asp Gly Leu Asp 
225                 230                 235                 240 


Pro Asn Asp Phe Asp Pro Lys Thr Phe Phe Lys Leu His Asp Val Asn 
                245                 250                 255     


Ser Asp Gly Phe Leu Asp Glu Gln Glu Leu Glu Ala Leu Phe Thr Lys 
            260                 265                 270         


Glu Leu Glu Lys Val Tyr Asp Pro Lys Asn Glu Glu Asp Asp Met Val 
        275                 280                 285             


Glu Met Glu Glu Glu Arg Leu Arg Met Arg Glu His Val Met Asn Glu 
    290                 295                 300                 


Val Asp Thr Asn Lys Asp Arg Leu Val Thr Leu Glu Glu Phe Leu Lys 
305                 310                 315                 320 


Ala Thr Glu Lys Lys Glu Phe Leu Glu Pro Asp Ser Trp Glu Thr Leu 
                325                 330                 335     


Asp Gln Gln Gln Phe Phe Thr Glu Glu Glu Leu Lys Glu Tyr Glu Asn 
            340                 345                 350         


Ile Ile Ala Leu Gln Glu Asn Glu Leu Lys Lys Lys Ala Asp Glu Leu 
        355                 360                 365             


Gln Lys Gln Lys Glu Glu Leu Gln Arg Gln His Asp Gln Leu Glu Ala 
    370                 375                 380                 


Gln Lys Leu Glu Tyr His Gln Val Ile Gln Gln Met Glu Gln Lys Lys 
385                 390                 395                 400 


Leu Gln Gln Gly Ile Pro Pro Ser Gly Pro Ala Gly Glu Leu Lys Phe 
                405                 410                 415     


Glu Pro His Ile 
            420 


<210>  9672
<211>  231
<212>  PRT
<213>  Homo Sapiens

<400>  9672

Met Arg Trp Arg Thr Ile Leu Leu Gln Tyr Cys Phe Leu Leu Ile Thr 
1               5                   10                  15      


Cys Leu Leu Thr Ala Leu Glu Ala Val Pro Ile Asp Ile Asp Lys Thr 
            20                  25                  30          


Lys Val Gln Asn Ile His Pro Val Glu Ser Ala Lys Ile Glu Pro Pro 
        35                  40                  45              


Asp Thr Gly Leu Tyr Tyr Asp Glu Tyr Leu Lys Gln Val Ile Asp Val 
    50                  55                  60                  


Leu Glu Thr Asp Lys His Phe Arg Glu Lys Leu Gln Lys Ala Asp Ile 
65                  70                  75                  80  


Glu Glu Ile Lys Ser Gly Arg Leu Ser Lys Glu Leu Asp Leu Val Ser 
                85                  90                  95      


His His Val Arg Thr Lys Leu Asp Glu Leu Lys Arg Gln Glu Val Gly 
            100                 105                 110         


Arg Leu Arg Met Leu Ile Lys Ala Lys Leu Asp Ser Leu Gln Asp Ile 
        115                 120                 125             


Gly Met Asp His Gln Ala Leu Leu Lys Gln Phe Asp His Leu Asn His 
    130                 135                 140                 


Leu Asn Pro Asp Lys Phe Glu Ser Thr Asp Leu Asp Met Leu Ile Lys 
145                 150                 155                 160 


Ala Ala Thr Ser Asp Leu Glu His Tyr Asp Lys Thr Arg His Glu Glu 
                165                 170                 175     


Phe Lys Lys Tyr Glu Met Met Lys Glu His Glu Arg Arg Glu Tyr Leu 
            180                 185                 190         


Lys Thr Leu Asn Glu Glu Lys Arg Lys Glu Glu Glu Ser Lys Phe Glu 
        195                 200                 205             


Glu Met Lys Lys Lys His Glu Asn His Pro Lys Val Asn His Pro Val 
    210                 215                 220                 


His Arg Glu Ala Lys Ile Asn 
225                 230     


<210>  9673
<211>  73
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9673

Xaa Glu Glu Arg Leu Arg Met Arg Glu His Val Met Asn Glu Val Asp 
1               5                   10                  15      


Thr Asn Lys Asp Arg Leu Val Thr Leu Glu Glu Phe Leu Lys Ala Thr 
            20                  25                  30          


Glu Lys Lys Glu Phe Leu Glu Pro Asp Ser Trp Glu Val Ile Gln Gln 
        35                  40                  45              


Met Glu Gln Lys Lys Leu Gln Gln Gly Ile Pro Pro Ser Gly Pro Ala 
    50                  55                  60                  


Gly Glu Leu Lys Phe Glu Pro His Ile 
65                  70              


<210>  9674
<211>  198
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9674

Xaa Thr Leu Asn Glu Glu Lys Arg Lys Glu Glu Glu Ser Lys Phe Glu 
1               5                   10                  15      


Glu Met Lys Lys Lys His Glu Asn His Pro Lys Val Asn His Pro Gly 
            20                  25                  30          


Ser Lys Asp Gln Leu Lys Glu Val Trp Glu Glu Thr Asp Gly Leu Asp 
        35                  40                  45              


Pro Asn Asp Phe Asp Pro Lys Thr Phe Phe Lys Leu His Asp Val Asn 
    50                  55                  60                  


Ser Asp Gly Phe Leu Asp Glu Gln Glu Leu Glu Ala Leu Phe Thr Lys 
65                  70                  75                  80  


Glu Leu Glu Lys Val Tyr Asp Pro Lys Asn Glu Glu Asp Asp Met Val 
                85                  90                  95      


Glu Met Glu Glu Glu Arg Leu Arg Met Arg Glu His Val Met Asn Glu 
            100                 105                 110         


Thr Leu Asp Gln Gln Gln Phe Phe Thr Glu Glu Glu Leu Lys Glu Tyr 
        115                 120                 125             


Glu Asn Ile Ile Ala Leu Gln Glu Asn Glu Leu Lys Lys Lys Ala Asp 
    130                 135                 140                 


Glu Leu Gln Lys Gln Lys Glu Glu Leu Gln Arg Gln His Asp Gln Leu 
145                 150                 155                 160 


Glu Ala Gln Lys Leu Glu Tyr His Gln Val Ile Gln Gln Met Glu Gln 
                165                 170                 175     


Lys Lys Leu Gln Gln Gly Ile Pro Pro Ser Gly Pro Ala Gly Glu Leu 
            180                 185                 190         


Lys Phe Glu Pro His Ile 
        195             


<210>  9675
<211>  375
<212>  PRT
<213>  Homo Sapiens

<400>  9675

Met Ser Ser Ser Leu Arg Pro Gly Pro Ser Arg Trp Arg Arg Ala Ala 
1               5                   10                  15      


Ser Ile Val Leu Ala Ala Gly Trp Ser Arg Pro Glu Thr Ala Thr Pro 
            20                  25                  30          


Pro Ser Arg Pro Pro Pro Ala Glu Gly Phe Arg Leu Leu Leu Leu Gln 
        35                  40                  45              


Arg Ser Pro His Gln Gly Phe Met Pro Gly Ala His Val Phe Ser Gly 
    50                  55                  60                  


Gly Val Leu Asp Ala Ala Asp Arg Ser Ala Asp Trp Leu Gly Leu Phe 
65                  70                  75                  80  


Ala Pro His His Gly Pro Pro Arg Phe Gly Leu Gly Pro Ala Pro Phe 
                85                  90                  95      


Ser Arg Thr Ala Phe Pro Ser Leu Pro Asp Thr Asp Asp His Lys Thr 
            100                 105                 110         


Asp Asn Thr Gly Thr Leu Pro Glu Asp Val Ala Phe Arg Ile Cys Ala 
        115                 120                 125             


Val Arg Glu Ala Phe Glu Glu Ala Gly Val Leu Leu Leu Arg Pro Arg 
    130                 135                 140                 


Thr Ser Pro Pro Gly Pro Ala Pro Gly Pro Gly Leu Ala Leu Glu Pro 
145                 150                 155                 160 


Pro Pro Gly Leu Ala Ser Trp Arg Asp Arg Val Arg Gln Asp Pro Arg 
                165                 170                 175     


His Phe Leu Arg Leu Cys Ala His Leu Asp Cys Thr Pro Asp Ile Trp 
            180                 185                 190         


Ala Leu His Asn Trp Ser Ala Trp Leu Thr Pro Phe Leu Arg Gly Thr 
        195                 200                 205             


Thr Arg Arg Phe Asp Thr Ala Phe Phe Leu Cys Cys Leu Arg Glu Pro 
    210                 215                 220                 


Pro Pro Val Tyr Pro Asp Leu Ala Glu Val Val Gly Tyr Gln Trp Ser 
225                 230                 235                 240 


Ser Pro Ser Glu Ala Thr Glu Ser Phe Leu Ser Lys Glu Ile Trp Leu 
                245                 250                 255     


Pro Pro Pro Gln Phe Tyr Glu Val Arg Arg Leu Ala Asn Phe Ala Ser 
            260                 265                 270         


Leu Ser Asp Leu His Lys Phe Cys Leu Gly Arg Ala Leu Glu Gly Leu 
        275                 280                 285             


Glu Arg Trp Leu Pro Ile Ile Leu Leu Thr Ala Asp Gly Met Val His 
    290                 295                 300                 


Leu Leu Pro Gly Asp Glu Leu Tyr Leu Glu Asp Ser Asp Phe Leu Glu 
305                 310                 315                 320 


Asn Leu Met Ser Thr Glu Lys Lys Thr Glu Glu Ile Met Lys Glu Gly 
                325                 330                 335     


Lys Gln Phe His Arg Ile Val Thr Tyr His Arg His Leu Tyr Asp Ile 
            340                 345                 350         


His Val Thr Val Gln Pro Lys Tyr Lys His Val Tyr Pro Lys Asn Ser 
        355                 360                 365             


Val Val Arg Lys Ser His Leu 
    370                 375 


<210>  9676
<211>  77
<212>  PRT
<213>  Homo Sapiens

<400>  9676

Met Ala Gly Arg Leu Leu Gly Lys Ala Leu Ala Ala Val Ser Leu Ser 
1               5                   10                  15      


Leu Ala Leu Ala Ser Val Thr Ile Arg Ser Ser Arg Cys Arg Gly Ile 
            20                  25                  30          


Gln Ala Phe Arg Asn Pro Ala Gly Arg Thr Gly Leu Val Gly Arg Gly 
        35                  40                  45              


Leu Leu Gly Arg Trp Gly Pro Asn His Ala Ala Asp Pro Ile Ile Thr 
    50                  55                  60                  


Arg Gly Trp Trp Ile Gln Glu Arg Arg Leu Val Pro His 
65                  70                  75          


<210>  9677
<211>  284
<212>  PRT
<213>  Homo Sapiens

<400>  9677

Met Ala Gly Arg Leu Leu Gly Lys Ala Leu Ala Ala Val Ser Leu Ser 
1               5                   10                  15      


Leu Ala Leu Ala Ser Val Thr Ile Arg Ser Ser Arg Cys Arg Gly Ile 
            20                  25                  30          


Gln Ala Phe Arg Asn Ser Phe Ser Ser Ser Trp Phe His Leu Asn Thr 
        35                  40                  45              


Asn Val Met Ser Gly Ser Asn Gly Ser Lys Glu Asn Ser His Asn Lys 
    50                  55                  60                  


Ala Arg Thr Ser Pro Tyr Pro Gly Ser Lys Val Glu Arg Ser Gln Val 
65                  70                  75                  80  


Pro Asn Glu Lys Val Gly Trp Leu Val Glu Trp Gln Asp Tyr Lys Pro 
                85                  90                  95      


Val Glu Tyr Thr Ala Val Ser Val Leu Ala Gly Pro Arg Trp Ala Asp 
            100                 105                 110         


Pro Gln Ile Arg Asn Pro Ala Gly Arg Thr Gly Leu Val Gly Arg Gly 
        115                 120                 125             


Leu Leu Gly Arg Trp Gly Pro Asn His Ala Ala Asp Pro Ile Ile Thr 
    130                 135                 140                 


Arg Trp Lys Arg Asp Ser Ser Gly Asn Lys Ile Met His Pro Val Ser 
145                 150                 155                 160 


Gly Lys His Ile Leu Gln Phe Val Ala Ile Lys Arg Lys Asp Cys Gly 
                165                 170                 175     


Glu Trp Ala Ile Pro Gly Gly Met Val Asp Pro Gly Glu Lys Ile Ser 
            180                 185                 190         


Ala Thr Leu Lys Arg Glu Phe Gly Glu Glu Ala Leu Asn Ser Leu Gln 
        195                 200                 205             


Lys Thr Ser Ala Glu Lys Arg Glu Ile Glu Glu Lys Leu His Lys Leu 
    210                 215                 220                 


Phe Ser Gln Asp His Leu Val Ile Tyr Lys Gly Tyr Val Asp Asp Pro 
225                 230                 235                 240 


Arg Asn Thr Asp Asn Ala Trp Met Glu Thr Glu Ala Val Asn Tyr His 
                245                 250                 255     


Asp Glu Thr Gly Glu Ile Met Asp Asn Leu Met Leu Glu Ala Gly Asp 
            260                 265                 270         


Asp Ala Gly Lys Val Lys Trp Val Asp Ile Asn Asp 
        275                 280                 


<210>  9678
<211>  350
<212>  PRT
<213>  Homo Sapiens

<400>  9678

Met Ala Gly Arg Leu Leu Gly Lys Ala Leu Ala Ala Val Ser Leu Ser 
1               5                   10                  15      


Leu Ala Leu Ala Ser Val Thr Ile Arg Ser Ser Arg Cys Arg Gly Ile 
            20                  25                  30          


Gln Ala Phe Arg Asn Ser Phe Ser Ser Ser Trp Phe His Leu Asn Thr 
        35                  40                  45              


Asn Val Met Ser Gly Ser Asn Gly Ser Lys Glu Asn Ser His Asn Lys 
    50                  55                  60                  


Ala Arg Thr Ser Pro Tyr Pro Gly Ser Lys Val Glu Arg Ser Gln Val 
65                  70                  75                  80  


Pro Asn Glu Lys Val Gly Trp Leu Val Glu Trp Gln Asp Tyr Lys Pro 
                85                  90                  95      


Val Glu Tyr Thr Ala Val Ser Val Leu Ala Gly Pro Arg Trp Ala Asp 
            100                 105                 110         


Pro Gln Ile Ser Glu Ser Asn Phe Ser Pro Lys Phe Asn Glu Lys Asp 
        115                 120                 125             


Gly His Val Glu Arg Lys Ser Lys Asn Gly Leu Tyr Glu Ile Glu Asn 
    130                 135                 140                 


Gly Arg Pro Arg Asn Pro Ala Gly Arg Thr Gly Leu Val Gly Arg Gly 
145                 150                 155                 160 


Leu Leu Gly Arg Trp Gly Pro Asn His Ala Ala Asp Pro Ile Ile Thr 
                165                 170                 175     


Arg Trp Lys Arg Asp Ser Ser Gly Asn Lys Ile Met His Pro Val Ser 
            180                 185                 190         


Gly Lys His Ile Leu Gln Phe Val Ala Ile Lys Arg Lys Asp Cys Gly 
        195                 200                 205             


Glu Trp Ala Ile Pro Gly Gly Met Val Asp Pro Gly Glu Lys Ile Ser 
    210                 215                 220                 


Ala Thr Leu Lys Arg Glu Phe Gly Glu Glu Ala Leu Asn Ser Leu Gln 
225                 230                 235                 240 


Lys Thr Ser Ala Glu Lys Arg Glu Ile Glu Glu Lys Leu His Lys Leu 
                245                 250                 255     


Phe Ser Gln Asp His Leu Val Ile Tyr Lys Gly Tyr Val Asp Asp Pro 
            260                 265                 270         


Arg Asn Thr Asp Asn Ala Trp Met Glu Thr Glu Ala Val Asn Tyr His 
        275                 280                 285             


Asp Glu Thr Gly Glu Ile Met Asp Asn Leu Met Leu Glu Ala Gly Asp 
    290                 295                 300                 


Asp Ala Gly Lys Val Lys Trp Val Asp Ile Asn Asp Lys Leu Lys Leu 
305                 310                 315                 320 


Tyr Ala Ser His Ser Gln Phe Ile Lys Leu Val Ala Glu Lys Arg Asp 
                325                 330                 335     


Ala His Trp Ser Glu Asp Ser Glu Ala Asp Cys His Ala Leu 
            340                 345                 350 


<210>  9679
<211>  206
<212>  PRT
<213>  Homo Sapiens

<400>  9679

Met Ser Gly Ser Asn Gly Ser Lys Glu Asn Ser His Asn Lys Ala Arg 
1               5                   10                  15      


Thr Ser Pro Tyr Pro Gly Ser Lys Val Glu Arg Ser Gln Val Pro Asn 
            20                  25                  30          


Glu Lys Val Gly Trp Leu Val Glu Trp Gln Asp Tyr Lys Pro Val Glu 
        35                  40                  45              


Tyr Thr Ala Val Ser Val Leu Ala Gly Pro Arg Trp Ala Asp Pro Gln 
    50                  55                  60                  


Ile Ser Glu Ser Asn Phe Ser Pro Lys Phe Asn Glu Lys Asp Gly His 
65                  70                  75                  80  


Val Glu Arg Lys Ser Lys Asn Gly Leu Tyr Glu Ile Glu Asn Gly Arg 
                85                  90                  95      


Pro Arg Asn Pro Ala Gly Arg Thr Gly Leu Val Gly Arg Gly Leu Leu 
            100                 105                 110         


Gly Arg Trp Gly Pro Asn His Ala Ala Asp Pro Ile Ile Thr Arg Trp 
        115                 120                 125             


Lys Arg Asp Ser Ser Gly Asn Lys Ile Met His Pro Val Ser Gly Lys 
    130                 135                 140                 


His Ile Leu Gln Phe Val Ala Ile Lys Arg Lys Asp Cys Gly Glu Trp 
145                 150                 155                 160 


Ala Ile Pro Gly Gly Met Val Asp Pro Gly Glu Lys Ile Ser Ala Thr 
                165                 170                 175     


Leu Lys Arg Glu Phe Gly Glu Glu Ala Leu Asn Ser Leu Gln Lys Thr 
            180                 185                 190         


Ser Ala Glu Lys Arg Glu Ile Glu Glu Lys Leu His Lys Leu 
        195                 200                 205     


<210>  9680
<211>  300
<212>  PRT
<213>  Homo Sapiens

<400>  9680

Met Ser Gly Ser Asn Gly Ser Lys Glu Asn Ser His Asn Lys Ala Arg 
1               5                   10                  15      


Thr Ser Pro Tyr Pro Gly Ser Lys Val Glu Arg Ser Gln Val Pro Asn 
            20                  25                  30          


Glu Lys Val Gly Trp Leu Val Glu Trp Gln Asp Tyr Lys Pro Val Glu 
        35                  40                  45              


Tyr Thr Ala Val Ser Val Leu Ala Gly Pro Arg Trp Ala Asp Pro Gln 
    50                  55                  60                  


Ile Ser Glu Ser Asn Phe Ser Pro Lys Phe Asn Glu Lys Asp Gly His 
65                  70                  75                  80  


Val Glu Arg Lys Ser Lys Asn Gly Leu Tyr Glu Ile Glu Asn Gly Arg 
                85                  90                  95      


Pro Arg Asn Pro Ala Gly Arg Thr Gly Leu Val Gly Arg Gly Leu Leu 
            100                 105                 110         


Gly Arg Trp Gly Pro Asn His Ala Ala Asp Pro Ile Ile Thr Arg Trp 
        115                 120                 125             


Lys Arg Asp Ser Ser Gly Asn Lys Ile Met His Pro Val Ser Gly Lys 
    130                 135                 140                 


His Ile Leu Gln Phe Val Ala Ile Lys Arg Lys Asp Cys Gly Glu Trp 
145                 150                 155                 160 


Ala Ile Pro Gly Gly Met Val Asp Pro Gly Glu Lys Ile Ser Ala Thr 
                165                 170                 175     


Leu Lys Arg Glu Phe Gly Glu Glu Ala Leu Asn Ser Leu Gln Lys Thr 
            180                 185                 190         


Ser Ala Glu Lys Arg Glu Ile Glu Glu Lys Leu His Lys Leu Phe Ser 
        195                 200                 205             


Gln Asp His Leu Val Ile Tyr Lys Gly Tyr Val Asp Asp Pro Arg Asn 
    210                 215                 220                 


Thr Asp Asn Ala Trp Met Glu Thr Glu Ala Val Asn Tyr His Asp Glu 
225                 230                 235                 240 


Thr Gly Glu Ile Met Asp Asn Leu Met Leu Glu Ala Gly Asp Asp Ala 
                245                 250                 255     


Gly Lys Val Lys Trp Val Asp Ile Asn Asp Lys Leu Lys Leu Tyr Ala 
            260                 265                 270         


Ser His Ser Gln Phe Ile Lys Leu Val Ala Glu Lys Arg Asp Ala His 
        275                 280                 285             


Trp Ser Glu Asp Ser Glu Ala Asp Cys His Ala Leu 
    290                 295                 300 


<210>  9681
<211>  1391
<212>  PRT
<213>  Homo Sapiens

<400>  9681

Met Pro Ser Ser Leu Leu Gly Ala Ala Met Pro Ala Ser Thr Ser Ala 
1               5                   10                  15      


Ala Ala Leu Gln Glu Ala Leu Glu Asn Ala Gly Arg Leu Ile Asp Arg 
            20                  25                  30          


Gln Leu Gln Glu Asp Arg Met Tyr Pro Asp Leu Ser Glu Leu Leu Met 
        35                  40                  45              


Val Ser Ala Pro Asn Asn Pro Thr Val Ser Gly Met Ser Asp Met Asp 
    50                  55                  60                  


Tyr Pro Leu Gln Gly Pro Gly Leu Leu Ser Val Pro Asn Leu Pro Glu 
65                  70                  75                  80  


Ile Ser Ser Ile Arg Arg Val Pro Leu Pro Pro Glu Leu Val Glu Gln 
                85                  90                  95      


Phe Gly His Met Gln Cys Asn Cys Met Met Gly Val Phe Pro Pro Ile 
            100                 105                 110         


Ser Arg Ala Trp Leu Thr Ile Asp Ser Asp Ile Phe Met Trp Asn Tyr 
        115                 120                 125             


Glu Asp Gly Gly Asp Leu Ala Tyr Phe Asp Gly Leu Ser Glu Thr Ile 
    130                 135                 140                 


Leu Ala Val Gly Leu Val Lys Pro Lys Ala Gly Ile Phe Gln Pro His 
145                 150                 155                 160 


Val Arg His Leu Leu Val Leu Ala Thr Pro Val Asp Ile Val Ile Leu 
                165                 170                 175     


Gly Leu Ser Tyr Ala Asn Leu Gln Thr Gly Ser Gly Val Leu Asn Asp 
            180                 185                 190         


Ser Leu Ser Gly Gly Met Gln Leu Leu Pro Asp Pro Leu Tyr Ser Leu 
        195                 200                 205             


Pro Thr Asp Asn Thr Tyr Leu Leu Thr Ile Thr Ser Thr Asp Asn Gly 
    210                 215                 220                 


Arg Ile Phe Leu Ala Gly Lys Asp Gly Cys Leu Tyr Glu Val Ala Tyr 
225                 230                 235                 240 


Gln Ala Glu Ala Gly Trp Phe Ser Gln Arg Cys Arg Lys Ile Asn His 
                245                 250                 255     


Ser Lys Ser Ser Leu Ser Phe Leu Val Pro Ser Leu Leu Gln Phe Thr 
            260                 265                 270         


Phe Ser Glu Asp Asp Pro Ile Leu Gln Ile Ala Ile Asp Asn Ser Arg 
        275                 280                 285             


Asn Ile Leu Tyr Thr Arg Ser Glu Lys Gly Val Ile Gln Val Tyr Asp 
    290                 295                 300                 


Leu Gly Gln Asp Gly Gln Gly Met Ser Arg Val Ala Ser Val Ser Gln 
305                 310                 315                 320 


Asn Ala Ile Val Ser Ala Ala Gly Asn Ile Ala Arg Thr Ile Asp Arg 
                325                 330                 335     


Ser Val Phe Lys Pro Ile Val Gln Ile Ala Val Ile Glu Asn Ser Glu 
            340                 345                 350         


Ser Leu Asp Cys Gln Leu Leu Ala Val Thr His Ala Gly Val Arg Leu 
        355                 360                 365             


Tyr Phe Ser Thr Cys Pro Phe Arg Gln Pro Leu Ala Arg Pro Asn Thr 
    370                 375                 380                 


Leu Thr Leu Val His Val Arg Leu Pro Pro Gly Phe Ser Ala Ser Ser 
385                 390                 395                 400 


Thr Val Glu Lys Pro Ser Lys Val His Arg Ala Leu Tyr Ser Lys Gly 
                405                 410                 415     


Ile Leu Leu Met Ala Ala Ser Glu Asn Glu Asp Asn Asp Ile Leu Trp 
            420                 425                 430         


Cys Val Asn His Asp Thr Phe Pro Phe Gln Lys Pro Met Met Glu Thr 
        435                 440                 445             


Gln Met Thr Ala Gly Val Asp Gly His Ser Trp Ala Leu Ser Ala Ile 
    450                 455                 460                 


Asp Glu Leu Lys Val Asp Lys Ile Ile Thr Pro Leu Asn Lys Asp His 
465                 470                 475                 480 


Ile Pro Ile Thr Asp Ser Pro Val Val Val Gln Gln His Met Leu Pro 
                485                 490                 495     


Pro Lys Lys Phe Val Leu Leu Ser Ala Gln Gly Ser Leu Met Phe His 
            500                 505                 510         


Lys Leu Arg Pro Val Asp Gln Leu Arg His Leu Leu Val Ser Asn Val 
        515                 520                 525             


Gly Gly Asp Gly Glu Glu Ile Glu Arg Phe Phe Lys Leu His Gln Glu 
    530                 535                 540                 


Asp Gln Ala Cys Ala Thr Cys Leu Ile Leu Ala Cys Ser Thr Ala Ala 
545                 550                 555                 560 


Cys Asp Arg Glu Val Ser Ala Trp Ala Thr Arg Ala Phe Phe Arg Tyr 
                565                 570                 575     


Gly Gly Glu Ala Gln Met Arg Phe Pro Thr Thr Leu Pro Pro Pro Ser 
            580                 585                 590         


Asn Val Gly Pro Ile Leu Gly Ser Pro Val Tyr Ser Ser Ser Pro Val 
        595                 600                 605             


Pro Ser Gly Ser Pro Tyr Pro Asn Pro Ser Phe Leu Gly Thr Pro Ser 
    610                 615                 620                 


His Gly Ile Gln Pro Pro Ala Met Ser Thr Pro Val Cys Ala Leu Gly 
625                 630                 635                 640 


Asn Pro Ala Thr Gln Ala Thr Asn Met Ser Cys Val Thr Gly Pro Glu 
                645                 650                 655     


Ile Val Tyr Ser Gly Lys His Asn Gly Ile Cys Ile Tyr Phe Ser Arg 
            660                 665                 670         


Ile Met Gly Asn Ile Trp Asp Ala Ser Leu Val Val Glu Arg Ile Phe 
        675                 680                 685             


Lys Ser Gly Asn Arg Glu Ile Thr Ala Ile Glu Ser Ser Val Pro Cys 
    690                 695                 700                 


Gln Leu Leu Glu Ser Val Leu Gln Glu Leu Lys Gly Leu Gln Glu Phe 
705                 710                 715                 720 


Leu Asp Arg Asn Ser Gln Phe Ala Gly Gly Pro Leu Gly Asn Pro Asn 
                725                 730                 735     


Thr Thr Ala Lys Val Gln Gln Arg Leu Ile Gly Phe Met Arg Pro Glu 
            740                 745                 750         


Asn Gly Asn Pro Gln Gln Met Gln Gln Glu Leu Gln Arg Lys Phe His 
        755                 760                 765             


Glu Ala Gln Leu Ser Glu Lys Ile Ser Leu Gln Ala Ile Gln Gln Leu 
    770                 775                 780                 


Val Arg Lys Ser Tyr Gln Ala Leu Ala Leu Trp Lys Leu Leu Cys Glu 
785                 790                 795                 800 


His Gln Phe Thr Ile Ile Val Ala Glu Leu Gln Lys Glu Leu Gln Glu 
                805                 810                 815     


Gln Leu Lys Ile Thr Thr Phe Lys Asp Leu Val Ile Arg Asp Lys Glu 
            820                 825                 830         


Leu Thr Gly Ala Leu Ile Ala Ser Leu Ile Asn Cys Tyr Ile Arg Asp 
        835                 840                 845             


Asn Ala Ala Val Asp Gly Ile Ser Leu His Leu Gln Asp Ile Cys Pro 
    850                 855                 860                 


Leu Leu Tyr Ser Thr Asp Asp Ala Ile Cys Ser Lys Ala Asn Glu Leu 
865                 870                 875                 880 


Leu Gln Arg Ser Arg Gln Val Gln Asn Lys Thr Glu Lys Glu Arg Met 
                885                 890                 895     


Leu Arg Glu Ser Leu Lys Glu Tyr Gln Lys Ile Ser Asn Gln Val Asp 
            900                 905                 910         


Leu Ser Asn Val Cys Ala Gln Tyr Arg Gln Val Arg Phe Tyr Glu Gly 
        915                 920                 925             


Val Val Glu Leu Ser Leu Thr Ala Ala Glu Lys Lys Asp Pro Gln Gly 
    930                 935                 940                 


Leu Gly Leu His Phe Tyr Lys His Gly Glu Pro Glu Glu Asp Ile Val 
945                 950                 955                 960 


Gly Leu Gln Ala Phe Gln Glu Arg Leu Asn Ser Tyr Lys Cys Ile Thr 
                965                 970                 975     


Asp Thr Leu Gln Glu Leu Val Asn Gln Ser Lys Ala Ala Pro Gln Ser 
            980                 985                 990         


Pro Ser Val Pro Lys Lys Pro Gly  Pro Pro Val Leu Ser  Ser Asp Pro 
        995                 1000                 1005             


Asn Met  Leu Ser Asn Glu Glu  Ala Gly His His Phe  Glu Gln Met 
    1010                 1015                 1020             


Leu Lys  Leu Ser Gln Arg Ser  Lys Asp Glu Leu Phe  Ser Ile Ala 
    1025                 1030                 1035             


Leu Tyr  Asn Trp Leu Ile Gln  Val Asp Leu Ala Asp  Lys Leu Leu 
    1040                 1045                 1050             


Gln Val  Ala Ser Pro Phe Leu  Glu Pro His Leu Val  Arg Met Ala 
    1055                 1060                 1065             


Lys Val  Asp Gln Asn Arg Val  Arg Tyr Met Asp Leu  Leu Trp Arg 
    1070                 1075                 1080             


Tyr Tyr  Glu Lys Asn Arg Ser  Phe Ser Asn Ala Ala  Arg Val Leu 
    1085                 1090                 1095             


Ser Arg  Leu Ala Asp Met His  Ser Thr Glu Ile Ser  Leu Gln Gln 
    1100                 1105                 1110             


Arg Leu  Glu Tyr Ile Ala Arg  Ala Ile Leu Ser Ala  Lys Ser Ser 
    1115                 1120                 1125             


Thr Ala  Ile Ser Ser Ile Ala  Ala Asp Gly Glu Phe  Leu His Glu 
    1130                 1135                 1140             


Leu Glu  Glu Lys Met Glu Val  Ala Arg Ile Gln Leu  Gln Ile Gln 
    1145                 1150                 1155             


Glu Thr  Leu Gln Arg Gln Tyr  Ser His His Ser Ser  Val Gln Asp 
    1160                 1165                 1170             


Ala Val  Ser Gln Leu Asp Ser  Glu Leu Met Asp Ile  Thr Lys Leu 
    1175                 1180                 1185             


Tyr Gly  Glu Phe Ala Asp Pro  Phe Lys Leu Ala Glu  Cys Lys Leu 
    1190                 1195                 1200             


Ala Ile  Ile His Cys Ala Gly  Tyr Ser Asp Pro Ile  Leu Val Gln 
    1205                 1210                 1215             


Thr Leu  Trp Gln Asp Ile Ile  Glu Lys Glu Leu Ser  Asp Ser Val 
    1220                 1225                 1230             


Thr Leu  Ser Ser Ser Asp Arg  Met His Ala Leu Ser  Leu Lys Ile 
    1235                 1240                 1245             


Val Leu  Leu Gly Lys Ile Tyr  Ala Gly Thr Pro Arg  Phe Phe Pro 
    1250                 1255                 1260             


Leu Asp  Phe Ile Val Gln Phe  Leu Glu Gln Gln Val  Cys Thr Leu 
    1265                 1270                 1275             


Asn Trp  Asp Val Gly Phe Val  Ile Gln Thr Met Asn  Glu Ile Gly 
    1280                 1285                 1290             


Val Pro  Leu Pro Arg Leu Leu  Glu Val Tyr Asp Gln  Leu Phe Lys 
    1295                 1300                 1305             


Ser Arg  Asp Pro Phe Trp Asn  Arg Met Lys Lys Pro  Leu His Leu 
    1310                 1315                 1320             


Leu Asp  Cys Ile His Val Leu  Leu Ile Arg Tyr Val  Glu Asn Pro 
    1325                 1330                 1335             


Ser Gln  Val Leu Asn Cys Glu  Arg Arg Arg Phe Thr  Asn Leu Cys 
    1340                 1345                 1350             


Leu Asp  Ala Val Cys Gly Tyr  Leu Val Glu Leu Gln  Ser Met Ser 
    1355                 1360                 1365             


Ser Ser  Val Ala Val Gln Ala  Ile Thr Gly Asn Phe  Lys Ser Leu 
    1370                 1375                 1380             


Gln Ala  Lys Leu Glu Arg Leu  His 
    1385                 1390     


<210>  9682
<211>  1327
<212>  PRT
<213>  Homo Sapiens

<400>  9682

Met Pro Ser Ser Leu Leu Gly Ala Ala Met Pro Ala Ser Thr Ser Ala 
1               5                   10                  15      


Ala Ala Leu Gln Glu Ala Leu Glu Asn Ala Gly Arg Leu Ile Asp Arg 
            20                  25                  30          


Gln Leu Gln Glu Asp Arg Met Tyr Pro Asp Leu Ser Glu Leu Leu Met 
        35                  40                  45              


Val Ser Ala Pro Asn Asn Pro Thr Val Ser Gly Met Ser Asp Met Asp 
    50                  55                  60                  


Tyr Pro Leu Gln Gly Pro Gly Leu Leu Ser Val Pro Asn Leu Pro Glu 
65                  70                  75                  80  


Ile Ser Ser Ile Arg Arg Val Pro Leu Pro Pro Glu Leu Val Glu Gln 
                85                  90                  95      


Phe Gly His Met Gln Cys Asn Cys Met Met Gly Val Phe Pro Pro Ile 
            100                 105                 110         


Ser Arg Ala Trp Leu Thr Ile Asp Ser Asp Ile Phe Met Trp Asn Tyr 
        115                 120                 125             


Glu Asp Gly Gly Asp Leu Ala Tyr Phe Asp Gly Leu Ser Glu Thr Ile 
    130                 135                 140                 


Leu Ala Val Gly Leu Val Lys Pro Lys Ala Gly Ile Phe Gln Pro His 
145                 150                 155                 160 


Val Arg His Leu Leu Val Leu Ala Thr Pro Val Asp Ile Val Ile Leu 
                165                 170                 175     


Gly Leu Ser Tyr Ala Asn Leu Gln Thr Gly Ser Gly Val Leu Asn Asp 
            180                 185                 190         


Ser Leu Ser Gly Gly Met Gln Leu Leu Pro Asp Pro Leu Tyr Ser Leu 
        195                 200                 205             


Pro Thr Asp Asn Thr Tyr Leu Leu Thr Ile Thr Ser Thr Asp Asn Gly 
    210                 215                 220                 


Arg Ile Phe Leu Ala Gly Lys Asp Gly Cys Leu Tyr Glu Val Ala Tyr 
225                 230                 235                 240 


Gln Ala Glu Ala Gly Trp Phe Ser Gln Arg Cys Arg Lys Ile Asn His 
                245                 250                 255     


Ser Lys Ser Ser Leu Ser Phe Leu Val Pro Ser Leu Leu Gln Phe Thr 
            260                 265                 270         


Phe Ser Glu Asp Asp Pro Ile Leu Gln Ile Ala Ile Asp Asn Ser Arg 
        275                 280                 285             


Asn Ile Leu Tyr Thr Arg Ser Glu Lys Gly Val Ile Gln Val Tyr Asp 
    290                 295                 300                 


Leu Gly Gln Asp Gly Gln Gly Met Ser Arg Val Ala Ser Val Ser Gln 
305                 310                 315                 320 


Asn Ala Ile Val Ser Ala Ala Gly Asn Ile Ala Arg Thr Ile Asp Arg 
                325                 330                 335     


Ser Val Phe Lys Pro Ile Val Gln Ile Ala Val Ile Glu Asn Ser Glu 
            340                 345                 350         


Ser Leu Asp Cys Gln Leu Leu Ala Val Thr His Ala Gly Val Arg Leu 
        355                 360                 365             


Tyr Phe Ser Thr Cys Pro Phe Arg Gln Pro Leu Ala Arg Pro Asn Thr 
    370                 375                 380                 


Leu Thr Leu Val His Val Arg Leu Pro Pro Gly Phe Ser Ala Ser Ser 
385                 390                 395                 400 


Thr Val Glu Lys Pro Ser Lys Val His Arg Ala Leu Tyr Ser Lys Gly 
                405                 410                 415     


Ile Leu Leu Met Ala Ala Ser Glu Asn Glu Asp Asn Asp Ile Leu Trp 
            420                 425                 430         


Cys Val Asn His Asp Thr Phe Pro Phe Gln Lys Pro Met Met Glu Thr 
        435                 440                 445             


Gln Met Thr Ala Gly Val Asp Gly His Ser Trp Ala Leu Ser Ala Ile 
    450                 455                 460                 


Asp Glu Leu Lys Val Asp Lys Ile Ile Thr Pro Leu Asn Lys Asp His 
465                 470                 475                 480 


Ile Pro Ile Thr Asp Ser Pro Val Val Val Gln Gln His Met Leu Pro 
                485                 490                 495     


Pro Lys Lys Phe Val Leu Leu Ser Ala Gln Gly Ser Leu Met Phe His 
            500                 505                 510         


Lys Leu Arg Pro Val Asp Gln Leu Arg His Leu Leu Val Ser Asn Val 
        515                 520                 525             


Gly Gly Asp Gly Glu Glu Ile Glu Arg Phe Phe Lys Leu His Gln Glu 
    530                 535                 540                 


Asp Gln Ala Cys Ala Thr Cys Leu Ile Leu Ala Cys Ser Thr Ala Ala 
545                 550                 555                 560 


Cys Asp Arg Glu Val Ser Ala Trp Ala Thr Arg Ala Phe Phe Arg Tyr 
                565                 570                 575     


Gly Gly Glu Ala Gln Met Arg Phe Pro Thr Thr Leu Pro Pro Pro Ser 
            580                 585                 590         


Asn Val Gly Pro Ile Leu Gly Ser Pro Val Tyr Ser Ser Ser Pro Val 
        595                 600                 605             


Pro Ser Gly Ser Pro Tyr Pro Asn Pro Ser Phe Leu Gly Thr Pro Ser 
    610                 615                 620                 


His Gly Ile Gln Pro Pro Ala Met Ser Thr Pro Val Cys Ala Leu Gly 
625                 630                 635                 640 


Asn Pro Ala Thr Gln Ala Thr Asn Met Ser Cys Val Thr Gly Pro Glu 
                645                 650                 655     


Ile Val Tyr Ser Gly Lys His Asn Gly Ile Cys Ile Tyr Phe Ser Arg 
            660                 665                 670         


Ile Met Gly Asn Ile Trp Asp Ala Ser Leu Val Val Glu Arg Ile Phe 
        675                 680                 685             


Lys Ser Gly Asn Arg Glu Ile Thr Ala Ile Glu Ser Ser Val Pro Cys 
    690                 695                 700                 


Gln Leu Leu Glu Ser Val Leu Gln Glu Leu Lys Gly Leu Gln Glu Phe 
705                 710                 715                 720 


Leu Asp Arg Asn Ser Gln Phe Ala Gly Gly Pro Leu Gly Asn Pro Asn 
                725                 730                 735     


Thr Thr Ala Lys Val Gln Gln Arg Leu Ile Gly Phe Met Arg Pro Glu 
            740                 745                 750         


Asn Gly Asn Pro Gln Gln Met Gln Gln Glu Leu Gln Arg Lys Phe His 
        755                 760                 765             


Glu Ala Gln Leu Ser Glu Lys Ile Ser Leu Gln Ala Ile Gln Gln Leu 
    770                 775                 780                 


Val Arg Lys Ser Tyr Gln Ala Leu Ala Leu Trp Lys Leu Leu Cys Glu 
785                 790                 795                 800 


His Gln Phe Thr Ile Ile Val Ala Glu Leu Gln Lys Ala Asn Glu Leu 
                805                 810                 815     


Leu Gln Arg Ser Arg Gln Val Gln Asn Lys Thr Glu Lys Glu Arg Met 
            820                 825                 830         


Leu Arg Glu Ser Leu Lys Glu Tyr Gln Lys Ile Ser Asn Gln Val Asp 
        835                 840                 845             


Leu Ser Asn Val Cys Ala Gln Tyr Arg Gln Val Arg Phe Tyr Glu Gly 
    850                 855                 860                 


Val Val Glu Leu Ser Leu Thr Ala Ala Glu Lys Lys Asp Pro Gln Gly 
865                 870                 875                 880 


Leu Gly Leu His Phe Tyr Lys His Gly Glu Pro Glu Glu Asp Ile Val 
                885                 890                 895     


Gly Leu Gln Ala Phe Gln Glu Arg Leu Asn Ser Tyr Lys Cys Ile Thr 
            900                 905                 910         


Asp Thr Leu Gln Glu Leu Val Asn Gln Ser Lys Ala Ala Pro Gln Ser 
        915                 920                 925             


Pro Ser Val Pro Lys Lys Pro Gly Pro Pro Val Leu Ser Ser Asp Pro 
    930                 935                 940                 


Asn Met Leu Ser Asn Glu Glu Ala Gly His His Phe Glu Gln Met Leu 
945                 950                 955                 960 


Lys Leu Ser Gln Arg Ser Lys Asp Glu Leu Phe Ser Ile Ala Leu Tyr 
                965                 970                 975     


Asn Trp Leu Ile Gln Val Asp Leu Ala Asp Lys Leu Leu Gln Val Ala 
            980                 985                 990         


Ser Pro Phe Leu Glu Pro His Leu  Val Arg Met Ala Lys  Val Asp Gln 
        995                 1000                 1005             


Asn Arg  Val Arg Tyr Met Asp  Leu Leu Trp Arg Tyr  Tyr Glu Lys 
    1010                 1015                 1020             


Asn Arg  Ser Phe Ser Asn Ala  Ala Arg Val Leu Ser  Arg Leu Ala 
    1025                 1030                 1035             


Asp Met  His Ser Thr Glu Ile  Ser Leu Gln Gln Arg  Leu Glu Tyr 
    1040                 1045                 1050             


Ile Ala  Arg Ala Ile Leu Ser  Ala Lys Ser Ser Thr  Ala Ile Ser 
    1055                 1060                 1065             


Ser Ile  Ala Ala Asp Gly Glu  Phe Leu His Glu Leu  Glu Glu Lys 
    1070                 1075                 1080             


Met Glu  Val Ala Arg Ile Gln  Leu Gln Ile Gln Glu  Thr Leu Gln 
    1085                 1090                 1095             


Arg Gln  Tyr Ser His His Ser  Ser Val Gln Asp Ala  Val Ser Gln 
    1100                 1105                 1110             


Leu Asp  Ser Glu Leu Met Asp  Ile Thr Lys Leu Tyr  Gly Glu Phe 
    1115                 1120                 1125             


Ala Asp  Pro Phe Lys Leu Ala  Glu Cys Lys Leu Ala  Ile Ile His 
    1130                 1135                 1140             


Cys Ala  Gly Tyr Ser Asp Pro  Ile Leu Val Gln Thr  Leu Trp Gln 
    1145                 1150                 1155             


Asp Ile  Ile Glu Lys Glu Leu  Ser Asp Ser Val Thr  Leu Ser Ser 
    1160                 1165                 1170             


Ser Asp  Arg Met His Ala Leu  Ser Leu Lys Ile Val  Leu Leu Gly 
    1175                 1180                 1185             


Lys Ile  Tyr Ala Gly Thr Pro  Arg Phe Phe Pro Leu  Asp Phe Ile 
    1190                 1195                 1200             


Val Gln  Phe Leu Glu Gln Gln  Val Cys Thr Leu Asn  Trp Asp Val 
    1205                 1210                 1215             


Gly Phe  Val Ile Gln Thr Met  Asn Glu Ile Gly Val  Pro Leu Pro 
    1220                 1225                 1230             


Arg Leu  Leu Glu Val Tyr Asp  Gln Leu Phe Lys Ser  Arg Asp Pro 
    1235                 1240                 1245             


Phe Trp  Asn Arg Met Lys Lys  Pro Leu His Leu Leu  Asp Cys Ile 
    1250                 1255                 1260             


His Val  Leu Leu Ile Arg Tyr  Val Glu Asn Pro Ser  Gln Val Leu 
    1265                 1270                 1275             


Asn Cys  Glu Arg Arg Arg Phe  Thr Asn Leu Cys Leu  Asp Ala Val 
    1280                 1285                 1290             


Cys Gly  Tyr Leu Val Glu Leu  Gln Ser Met Ser Ser  Ser Val Ala 
    1295                 1300                 1305             


Val Gln  Ala Ile Thr Gly Asn  Phe Lys Ser Leu Gln  Ala Lys Leu 
    1310                 1315                 1320             


Glu Arg  Leu His 
    1325         


<210>  9683
<211>  54
<212>  PRT
<213>  Homo Sapiens

<400>  9683

Met Pro Ser Ser Leu Leu Gly Ala Ala Met Pro Ala Ser Thr Ser Ala 
1               5                   10                  15      


Ala Ala Leu Gln Glu Ala Leu Glu Asn Ala Gly Arg Leu Ile Asp Arg 
            20                  25                  30          


Gln Leu Gln Glu Asp Arg Met Tyr Pro Asp Leu Ser Glu Leu Leu Met 
        35                  40                  45              


Val Ser Ala Pro Ser Glu 
    50                  


<210>  9684
<211>  1332
<212>  PRT
<213>  Homo Sapiens

<400>  9684

Met Ser Asp Met Asp Tyr Pro Leu Gln Gly Pro Gly Leu Leu Ser Val 
1               5                   10                  15      


Pro Asn Leu Pro Glu Ile Ser Ser Ile Arg Arg Val Pro Leu Pro Pro 
            20                  25                  30          


Glu Leu Val Glu Gln Phe Gly His Met Gln Cys Asn Cys Met Met Gly 
        35                  40                  45              


Val Phe Pro Pro Ile Ser Arg Ala Trp Leu Thr Ile Asp Ser Asp Ile 
    50                  55                  60                  


Phe Met Trp Asn Tyr Glu Asp Gly Gly Asp Leu Ala Tyr Phe Asp Gly 
65                  70                  75                  80  


Leu Ser Glu Thr Ile Leu Ala Val Gly Leu Val Lys Pro Lys Ala Gly 
                85                  90                  95      


Ile Phe Gln Pro His Val Arg His Leu Leu Val Leu Ala Thr Pro Val 
            100                 105                 110         


Asp Ile Val Ile Leu Gly Leu Ser Tyr Ala Asn Leu Gln Thr Gly Ser 
        115                 120                 125             


Gly Val Leu Asn Asp Ser Leu Ser Gly Gly Met Gln Leu Leu Pro Asp 
    130                 135                 140                 


Pro Leu Tyr Ser Leu Pro Thr Asp Asn Thr Tyr Leu Leu Thr Ile Thr 
145                 150                 155                 160 


Ser Thr Asp Asn Gly Arg Ile Phe Leu Ala Gly Lys Asp Gly Cys Leu 
                165                 170                 175     


Tyr Glu Val Ala Tyr Gln Ala Glu Ala Gly Trp Phe Ser Gln Arg Cys 
            180                 185                 190         


Arg Lys Ile Asn His Ser Lys Ser Ser Leu Ser Phe Leu Val Pro Ser 
        195                 200                 205             


Leu Leu Gln Phe Thr Phe Ser Glu Asp Asp Pro Ile Leu Gln Ile Ala 
    210                 215                 220                 


Ile Asp Asn Ser Arg Asn Ile Leu Tyr Thr Arg Ser Glu Lys Gly Val 
225                 230                 235                 240 


Ile Gln Val Tyr Asp Leu Gly Gln Asp Gly Gln Gly Met Ser Arg Val 
                245                 250                 255     


Ala Ser Val Ser Gln Asn Ala Ile Val Ser Ala Ala Gly Asn Ile Ala 
            260                 265                 270         


Arg Thr Ile Asp Arg Ser Val Phe Lys Pro Ile Val Gln Ile Ala Val 
        275                 280                 285             


Ile Glu Asn Ser Glu Ser Leu Asp Cys Gln Leu Leu Ala Val Thr His 
    290                 295                 300                 


Ala Gly Val Arg Leu Tyr Phe Ser Thr Cys Pro Phe Arg Gln Pro Leu 
305                 310                 315                 320 


Ala Arg Pro Asn Thr Leu Thr Leu Val His Val Arg Leu Pro Pro Gly 
                325                 330                 335     


Phe Ser Ala Ser Ser Thr Val Glu Lys Pro Ser Lys Val His Arg Ala 
            340                 345                 350         


Leu Tyr Ser Lys Gly Ile Leu Leu Met Ala Ala Ser Glu Asn Glu Asp 
        355                 360                 365             


Asn Asp Ile Leu Trp Cys Val Asn His Asp Thr Phe Pro Phe Gln Lys 
    370                 375                 380                 


Pro Met Met Glu Thr Gln Met Thr Ala Gly Val Asp Gly His Ser Trp 
385                 390                 395                 400 


Ala Leu Ser Ala Ile Asp Glu Leu Lys Val Asp Lys Ile Ile Thr Pro 
                405                 410                 415     


Leu Asn Lys Asp His Ile Pro Ile Thr Asp Ser Pro Val Val Val Gln 
            420                 425                 430         


Gln His Met Leu Pro Pro Lys Lys Phe Val Leu Leu Ser Ala Gln Gly 
        435                 440                 445             


Ser Leu Met Phe His Lys Leu Arg Pro Val Asp Gln Leu Arg His Leu 
    450                 455                 460                 


Leu Val Ser Asn Val Gly Gly Asp Gly Glu Glu Ile Glu Arg Phe Phe 
465                 470                 475                 480 


Lys Leu His Gln Glu Asp Gln Ala Cys Ala Thr Cys Leu Ile Leu Ala 
                485                 490                 495     


Cys Ser Thr Ala Ala Cys Asp Arg Glu Val Ser Ala Trp Ala Thr Arg 
            500                 505                 510         


Ala Phe Phe Arg Tyr Gly Gly Glu Ala Gln Met Arg Phe Pro Thr Thr 
        515                 520                 525             


Leu Pro Pro Pro Ser Asn Val Gly Pro Ile Leu Gly Ser Pro Val Tyr 
    530                 535                 540                 


Ser Ser Ser Pro Val Pro Ser Gly Ser Pro Tyr Pro Asn Pro Ser Phe 
545                 550                 555                 560 


Leu Gly Thr Pro Ser His Gly Ile Gln Pro Pro Ala Met Ser Thr Pro 
                565                 570                 575     


Val Cys Ala Leu Gly Asn Pro Ala Thr Gln Ala Thr Asn Met Ser Cys 
            580                 585                 590         


Val Thr Gly Pro Glu Ile Val Tyr Ser Gly Lys His Asn Gly Ile Cys 
        595                 600                 605             


Ile Tyr Phe Ser Arg Ile Met Gly Asn Ile Trp Asp Ala Ser Leu Val 
    610                 615                 620                 


Val Glu Arg Ile Phe Lys Ser Gly Asn Arg Glu Ile Thr Ala Ile Glu 
625                 630                 635                 640 


Ser Ser Val Pro Cys Gln Leu Leu Glu Ser Val Leu Gln Glu Leu Lys 
                645                 650                 655     


Gly Leu Gln Glu Phe Leu Asp Arg Asn Ser Gln Phe Ala Gly Gly Pro 
            660                 665                 670         


Leu Gly Asn Pro Asn Thr Thr Ala Lys Val Gln Gln Arg Leu Ile Gly 
        675                 680                 685             


Phe Met Arg Pro Glu Asn Gly Asn Pro Gln Gln Met Gln Gln Glu Leu 
    690                 695                 700                 


Gln Arg Lys Phe His Glu Ala Gln Leu Ser Glu Lys Ile Ser Leu Gln 
705                 710                 715                 720 


Ala Ile Gln Gln Leu Val Arg Lys Ser Tyr Gln Ala Leu Ala Leu Trp 
                725                 730                 735     


Lys Leu Leu Cys Glu His Gln Phe Thr Ile Ile Val Ala Glu Leu Gln 
            740                 745                 750         


Lys Glu Leu Gln Glu Gln Leu Lys Ile Thr Thr Phe Lys Asp Leu Val 
        755                 760                 765             


Ile Arg Asp Lys Glu Leu Thr Gly Ala Leu Ile Ala Ser Leu Ile Asn 
    770                 775                 780                 


Cys Tyr Ile Arg Asp Asn Ala Ala Val Asp Gly Ile Ser Leu His Leu 
785                 790                 795                 800 


Gln Asp Ile Cys Pro Leu Leu Tyr Ser Thr Asp Asp Ala Ile Cys Ser 
                805                 810                 815     


Lys Ala Asn Glu Leu Leu Gln Arg Ser Arg Gln Val Gln Asn Lys Thr 
            820                 825                 830         


Glu Lys Glu Arg Met Leu Arg Glu Ser Leu Lys Glu Tyr Gln Lys Ile 
        835                 840                 845             


Ser Asn Gln Val Asp Leu Ser Asn Val Cys Ala Gln Tyr Arg Gln Val 
    850                 855                 860                 


Arg Phe Tyr Glu Gly Val Val Glu Leu Ser Leu Thr Ala Ala Glu Lys 
865                 870                 875                 880 


Lys Asp Pro Gln Gly Leu Gly Leu His Phe Tyr Lys His Gly Glu Pro 
                885                 890                 895     


Glu Glu Asp Ile Val Gly Leu Gln Ala Phe Gln Glu Arg Leu Asn Ser 
            900                 905                 910         


Tyr Lys Cys Ile Thr Asp Thr Leu Gln Glu Leu Val Asn Gln Ser Lys 
        915                 920                 925             


Ala Ala Pro Gln Ser Pro Ser Val Pro Lys Lys Pro Gly Pro Pro Val 
    930                 935                 940                 


Leu Ser Ser Asp Pro Asn Met Leu Ser Asn Glu Glu Ala Gly His His 
945                 950                 955                 960 


Phe Glu Gln Met Leu Lys Leu Ser Gln Arg Ser Lys Asp Glu Leu Phe 
                965                 970                 975     


Ser Ile Ala Leu Tyr Asn Trp Leu Ile Gln Val Asp Leu Ala Asp Lys 
            980                 985                 990         


Leu Leu Gln Val Ala Ser Pro Phe  Leu Glu Pro His Leu  Val Arg Met 
        995                 1000                 1005             


Ala Lys  Val Asp Gln Asn Arg  Val Arg Tyr Met Asp  Leu Leu Trp 
    1010                 1015                 1020             


Arg Tyr  Tyr Glu Lys Asn Arg  Ser Phe Ser Asn Ala  Ala Arg Val 
    1025                 1030                 1035             


Leu Ser  Arg Leu Ala Asp Met  His Ser Thr Glu Ile  Ser Leu Gln 
    1040                 1045                 1050             


Gln Arg  Leu Glu Tyr Ile Ala  Arg Ala Ile Leu Ser  Ala Lys Ser 
    1055                 1060                 1065             


Ser Thr  Ala Ile Ser Ser Ile  Ala Ala Asp Gly Glu  Phe Leu His 
    1070                 1075                 1080             


Glu Leu  Glu Glu Lys Met Glu  Val Ala Arg Ile Gln  Leu Gln Ile 
    1085                 1090                 1095             


Gln Glu  Thr Leu Gln Arg Gln  Tyr Ser His His Ser  Ser Val Gln 
    1100                 1105                 1110             


Asp Ala  Val Ser Gln Leu Asp  Ser Glu Leu Met Asp  Ile Thr Lys 
    1115                 1120                 1125             


Leu Tyr  Gly Glu Phe Ala Asp  Pro Phe Lys Leu Ala  Glu Cys Lys 
    1130                 1135                 1140             


Leu Ala  Ile Ile His Cys Ala  Gly Tyr Ser Asp Pro  Ile Leu Val 
    1145                 1150                 1155             


Gln Thr  Leu Trp Gln Asp Ile  Ile Glu Lys Glu Leu  Ser Asp Ser 
    1160                 1165                 1170             


Val Thr  Leu Ser Ser Ser Asp  Arg Met His Ala Leu  Ser Leu Lys 
    1175                 1180                 1185             


Ile Val  Leu Leu Gly Lys Ile  Tyr Ala Gly Thr Pro  Arg Phe Phe 
    1190                 1195                 1200             


Pro Leu  Asp Phe Ile Val Gln  Phe Leu Glu Gln Gln  Val Cys Thr 
    1205                 1210                 1215             


Leu Asn  Trp Asp Val Gly Phe  Val Ile Gln Thr Met  Asn Glu Ile 
    1220                 1225                 1230             


Gly Val  Pro Leu Pro Arg Leu  Leu Glu Val Tyr Asp  Gln Leu Phe 
    1235                 1240                 1245             


Lys Ser  Arg Asp Pro Phe Trp  Asn Arg Met Lys Lys  Pro Leu His 
    1250                 1255                 1260             


Leu Leu  Asp Cys Ile His Val  Leu Leu Ile Arg Tyr  Val Glu Asn 
    1265                 1270                 1275             


Pro Ser  Gln Val Leu Asn Cys  Glu Arg Arg Arg Phe  Thr Asn Leu 
    1280                 1285                 1290             


Cys Leu  Asp Ala Val Cys Gly  Tyr Leu Val Glu Leu  Gln Ser Met 
    1295                 1300                 1305             


Ser Ser  Ser Val Ala Val Gln  Ala Ile Thr Gly Asn  Phe Lys Ser 
    1310                 1315                 1320             


Leu Gln  Ala Lys Leu Glu Arg  Leu His 
    1325                 1330         


<210>  9685
<211>  140
<212>  PRT
<213>  Homo Sapiens

<400>  9685

Cys Lys Asp Asp Glu Ala Val Val Gln Ala Pro Arg His Ala Pro Val 
1               5                   10                  15      


Val Arg Thr Pro Ser Ile Gln Pro Ser Leu Leu Pro His Ala Ala Pro 
            20                  25                  30          


Phe Ala Lys Ser His Leu Val His Gly Ser Ser Pro Gly Val Met Gly 
        35                  40                  45              


Thr Ser Val Ala Thr Ser Ala Ser Lys Ile Ile Pro Gln Gly Ala Asp 
    50                  55                  60                  


Ser Thr Met Leu Ala Thr Lys Thr Val Lys His Gly Ala Pro Ser Pro 
65                  70                  75                  80  


Ser His Pro Ile Ser Ala Pro Gln Ala Ala Ala Ala Ala Ala Leu Arg 
                85                  90                  95      


Arg Gln Met Ala Ser Gln Ala Pro Ala Val Asn Thr Leu Thr Glu Ser 
            100                 105                 110         


Thr Leu Lys Asn Val Pro Gln Val Val Asn Val Gln Glu Leu Lys Asn 
        115                 120                 125             


Asn Pro Ala Thr Pro Ser Thr Ala Met Gly Gly Leu 
    130                 135                 140 


<210>  9686
<211>  78
<212>  PRT
<213>  Homo Sapiens

<400>  9686

Gly Glu Gly Thr Ala Ala Ala Ser Ala Gly Gly Phe Gly Phe Gly Ser 
1               5                   10                  15      


Ser Ser Asn Thr Thr Ser Phe Gly Thr Leu Ala Ser Gln Asn Ala Pro 
            20                  25                  30          


Thr Phe Gly Ser Leu Ser Gln Gln Thr Ser Gly Phe Gly Thr Gln Ser 
        35                  40                  45              


Ser Gly Phe Ser Gly Phe Gly Ser Gly Thr Gly Gly Phe Ser Phe Gly 
    50                  55                  60                  


Ser Asn Asn Ser Ser Val Gln Gly Phe Gly Gly Trp Arg Ser 
65                  70                  75              


<210>  9687
<211>  113
<212>  PRT
<213>  Homo Sapiens

<400>  9687

Leu Gln Cys Leu Ala Ala Leu Leu Leu Leu Gly Asp Pro Leu Gly Leu 
1               5                   10                  15      


Glu Gly Cys Gln His Ser Val Gln Pro Gln Pro Leu Gln Ala Leu Trp 
            20                  25                  30          


Ala Arg Arg Glu Ala Lys Cys Ser Glu Arg Ala Leu Gln Leu Pro Ala 
        35                  40                  45              


Gln Glu Asp Ser Gly Leu Gly Ala Ala Ala Thr Pro His Pro Ser Ala 
    50                  55                  60                  


Arg Ser Arg Val Arg Met Pro Pro Leu Ser Asp His Cys Pro Asn Arg 
65                  70                  75                  80  


Leu Leu Val Leu Gly Pro Arg Val Ala Asp Ser Leu Val Leu Asp Gln 
                85                  90                  95      


Ala Gln Glu Gly Ser Ala Leu Gly Gln Ile Thr Arg Lys Tyr Pro Pro 
            100                 105                 110         


Phe 
    


<210>  9688
<211>  2090
<212>  PRT
<213>  Homo Sapiens

<400>  9688

Met Gly Asp Glu Met Asp Ala Met Ile Pro Glu Arg Glu Met Lys Asp 
1               5                   10                  15      


Phe Gln Phe Arg Ala Leu Lys Lys Val Arg Ile Phe Asp Ser Pro Glu 
            20                  25                  30          


Glu Leu Pro Lys Glu Arg Ser Ser Leu Leu Ala Val Ser Asn Lys Tyr 
        35                  40                  45              


Gly Leu Val Phe Ala Gly Gly Ala Ser Gly Leu Gln Ile Phe Pro Thr 
    50                  55                  60                  


Lys Asn Leu Leu Ile Gln Asn Lys Pro Gly Asp Asp Pro Asn Lys Ile 
65                  70                  75                  80  


Val Asp Lys Val Gln Gly Leu Leu Val Pro Met Lys Phe Pro Ile His 
                85                  90                  95      


His Leu Ala Leu Ser Cys Asp Asn Leu Thr Leu Ser Ala Cys Met Met 
            100                 105                 110         


Ser Ser Glu Tyr Gly Ser Ile Ile Ala Phe Phe Asp Val Arg Thr Phe 
        115                 120                 125             


Ser Asn Glu Ala Lys Gln Gln Lys Arg Pro Phe Ala Tyr His Lys Leu 
    130                 135                 140                 


Leu Lys Asp Ala Gly Gly Met Val Ile Asp Met Lys Trp Asn Pro Thr 
145                 150                 155                 160 


Val Pro Ser Met Val Ala Val Cys Leu Ala Asp Gly Ser Ile Ala Val 
                165                 170                 175     


Leu Gln Val Thr Glu Thr Val Lys Val Cys Ala Thr Leu Pro Ser Thr 
            180                 185                 190         


Val Ala Val Thr Ser Val Cys Trp Ser Pro Lys Gly Lys Gln Leu Ala 
        195                 200                 205             


Val Gly Lys Gln Asn Gly Thr Val Val Gln Tyr Leu Pro Thr Leu Gln 
    210                 215                 220                 


Glu Lys Lys Val Ile Pro Cys Pro Pro Phe Tyr Glu Ser Asp His Pro 
225                 230                 235                 240 


Val Arg Val Leu Asp Val Leu Trp Ile Gly Thr Tyr Val Phe Ala Ile 
                245                 250                 255     


Val Tyr Ala Ala Ala Asp Gly Thr Leu Glu Thr Ser Pro Asp Val Val 
            260                 265                 270         


Met Ala Leu Leu Pro Lys Lys Glu Glu Lys His Pro Glu Ile Phe Val 
        275                 280                 285             


Asn Phe Met Glu Pro Cys Tyr Gly Ser Cys Thr Glu Arg Gln His His 
    290                 295                 300                 


Tyr Tyr Leu Ser Tyr Ile Glu Glu Trp Asp Leu Val Leu Ala Ala Ser 
305                 310                 315                 320 


Ala Ala Ser Thr Glu Val Ser Ile Leu Ala Arg Gln Ser Asp Gln Ile 
                325                 330                 335     


Asn Trp Glu Ser Trp Leu Leu Glu Asp Ser Ser Arg Ala Glu Leu Pro 
            340                 345                 350         


Val Thr Asp Lys Ser Asp Asp Ser Leu Pro Met Gly Val Val Val Asp 
        355                 360                 365             


Tyr Thr Asn Gln Val Glu Ile Thr Ile Ser Asp Glu Lys Thr Leu Pro 
    370                 375                 380                 


Pro Ala Pro Val Leu Met Leu Leu Ser Thr Asp Gly Val Leu Cys Pro 
385                 390                 395                 400 


Phe Tyr Met Ile Asn Gln Asn Pro Gly Val Lys Ser Leu Ile Lys Thr 
                405                 410                 415     


Pro Glu Arg Leu Ser Leu Glu Gly Glu Arg Gln Pro Lys Ser Pro Gly 
            420                 425                 430         


Ser Thr Pro Thr Thr Pro Thr Ser Ser Gln Ala Pro Gln Lys Leu Asp 
        435                 440                 445             


Ala Ser Ala Ala Ala Ala Pro Ala Ser Leu Pro Pro Ser Ser Pro Ala 
    450                 455                 460                 


Ala Pro Ile Ala Thr Phe Ser Leu Leu Pro Ala Gly Gly Ala Pro Thr 
465                 470                 475                 480 


Val Phe Ser Phe Gly Ser Ser Ser Leu Lys Ser Ser Ala Thr Val Thr 
                485                 490                 495     


Gly Glu Pro Pro Ser Tyr Ser Ser Gly Ser Asp Ser Ser Lys Ala Ala 
            500                 505                 510         


Pro Gly Pro Gly Pro Ser Thr Phe Ser Phe Val Pro Pro Ser Lys Ala 
        515                 520                 525             


Ser Leu Ala Pro Thr Pro Ala Ala Ser Pro Val Ala Pro Ser Ala Ala 
    530                 535                 540                 


Ser Phe Ser Phe Gly Ser Ser Gly Phe Lys Pro Thr Leu Glu Ser Thr 
545                 550                 555                 560 


Pro Val Pro Ser Val Ser Ala Pro Asn Ile Ala Met Lys Pro Ser Phe 
                565                 570                 575     


Pro Pro Ser Thr Ser Ala Val Lys Val Asn Leu Ser Glu Lys Phe Thr 
            580                 585                 590         


Ala Ala Ala Thr Ser Thr Pro Val Ser Ser Ser Gln Ser Ala Pro Pro 
        595                 600                 605             


Met Ser Pro Phe Ser Ser Ala Ser Lys Pro Ala Ala Ser Gly Pro Leu 
    610                 615                 620                 


Ser His Pro Thr Pro Leu Ser Ala Pro Pro Ser Ser Val Pro Leu Lys 
625                 630                 635                 640 


Ser Ser Val Leu Pro Ser Pro Ser Gly Arg Ser Ala Gln Gly Ser Ser 
                645                 650                 655     


Ser Pro Val Pro Ser Met Val Gln Lys Ser Pro Arg Ile Thr Pro Pro 
            660                 665                 670         


Ala Ala Lys Pro Gly Ser Pro Gln Ala Lys Ser Leu Gln Pro Ala Val 
        675                 680                 685             


Ala Glu Lys Gln Gly His Gln Trp Lys Asp Ser Asp Pro Val Met Ala 
    690                 695                 700                 


Gly Ile Gly Glu Glu Ile Ala His Phe Gln Lys Glu Leu Glu Glu Leu 
705                 710                 715                 720 


Lys Ala Arg Thr Ser Lys Ala Cys Phe Gln Val Gly Thr Ser Glu Glu 
                725                 730                 735     


Met Lys Met Leu Arg Thr Glu Ser Asp Asp Leu His Thr Phe Leu Leu 
            740                 745                 750         


Glu Ile Lys Glu Thr Thr Glu Ser Leu His Gly Asp Ile Ser Ser Leu 
        755                 760                 765             


Lys Thr Thr Leu Leu Glu Gly Phe Ala Gly Val Glu Glu Ala Arg Glu 
    770                 775                 780                 


Gln Asn Glu Arg Asn Arg Asp Ser Gly Tyr Leu His Leu Leu Tyr Lys 
785                 790                 795                 800 


Arg Pro Leu Asp Pro Lys Ser Glu Ala Gln Leu Gln Glu Ile Arg Arg 
                805                 810                 815     


Leu His Gln Tyr Val Lys Phe Ala Val Gln Asp Val Asn Asp Val Leu 
            820                 825                 830         


Asp Leu Glu Trp Asp Gln His Leu Glu Gln Lys Lys Lys Gln Arg His 
        835                 840                 845             


Leu Leu Val Pro Glu Arg Glu Thr Leu Phe Asn Thr Leu Ala Asn Asn 
    850                 855                 860                 


Arg Glu Ile Ile Asn Gln Gln Arg Lys Arg Leu Asn His Leu Val Asp 
865                 870                 875                 880 


Ser Leu Gln Gln Leu Arg Leu Tyr Lys Gln Thr Ser Leu Trp Ser Leu 
                885                 890                 895     


Ser Ser Ala Val Pro Ser Gln Ser Ser Ile His Ser Phe Asp Ser Asp 
            900                 905                 910         


Leu Glu Ser Leu Cys Asn Ala Leu Leu Lys Thr Thr Ile Glu Ser His 
        915                 920                 925             


Thr Lys Ser Leu Pro Lys Val Pro Ala Lys Leu Ser Pro Met Lys Gln 
    930                 935                 940                 


Ala Gln Leu Arg Asn Phe Leu Ala Lys Arg Lys Thr Pro Pro Val Arg 
945                 950                 955                 960 


Ser Thr Ala Pro Ala Ser Leu Ser Arg Ser Ala Phe Leu Ser Gln Arg 
                965                 970                 975     


Tyr Tyr Glu Asp Leu Asp Glu Val Ser Ser Thr Ser Ser Val Ser Gln 
            980                 985                 990         


Ser Leu Glu Ser Glu Asp Ala Arg  Thr Ser Cys Lys Asp  Asp Glu Ala 
        995                 1000                 1005             


Val Val  Gln Ala Pro Arg His  Ala Pro Val Val Arg  Thr Pro Ser 
    1010                 1015                 1020             


Ile Gln  Pro Ser Leu Leu Pro  His Ala Ala Pro Phe  Ala Lys Ser 
    1025                 1030                 1035             


His Leu  Val His Gly Ser Ser  Pro Gly Val Met Gly  Thr Ser Val 
    1040                 1045                 1050             


Ala Thr  Ser Ala Ser Lys Ile  Ile Pro Gln Gly Ala  Asp Ser Thr 
    1055                 1060                 1065             


Met Leu  Ala Thr Lys Thr Val  Lys His Gly Ala Pro  Ser Pro Ser 
    1070                 1075                 1080             


His Pro  Ile Ser Ala Pro Gln  Ala Ala Ala Ala Ala  Ala Leu Arg 
    1085                 1090                 1095             


Arg Gln  Met Ala Ser Gln Ala  Pro Ala Val Asn Thr  Leu Thr Glu 
    1100                 1105                 1110             


Ser Thr  Leu Lys Asn Val Pro  Gln Val Val Asn Val  Gln Glu Leu 
    1115                 1120                 1125             


Lys Asn  Asn Pro Ala Thr Pro  Ser Thr Ala Met Gly  Ser Ser Val 
    1130                 1135                 1140             


Pro Tyr  Ser Thr Ala Lys Thr  Pro His Pro Val Leu  Thr Pro Val 
    1145                 1150                 1155             


Ala Ala  Asn Gln Ala Lys Gln  Gly Ser Leu Ile Asn  Ser Leu Lys 
    1160                 1165                 1170             


Pro Ser  Gly Pro Thr Pro Ala  Ser Gly Gln Leu Ser  Ser Gly Asp 
    1175                 1180                 1185             


Lys Ala  Ser Gly Thr Ala Lys  Ile Glu Thr Ala Val  Thr Ser Thr 
    1190                 1195                 1200             


Pro Ser  Ala Ser Gly Gln Phe  Ser Lys Pro Phe Ser  Phe Ser Pro 
    1205                 1210                 1215             


Ser Gly  Thr Gly Phe Asn Phe  Gly Ile Ile Thr Pro  Thr Pro Ser 
    1220                 1225                 1230             


Ser Asn  Phe Thr Ala Ala Gln  Gly Ala Thr Pro Ser  Thr Lys Glu 
    1235                 1240                 1245             


Ser Ser  Gln Pro Asp Ala Phe  Ser Ser Gly Gly Gly  Ser Lys Pro 
    1250                 1255                 1260             


Ser Tyr  Glu Ala Ile Pro Glu  Ser Ser Pro Pro Ser  Gly Ile Thr 
    1265                 1270                 1275             


Ser Ala  Ser Asn Thr Thr Pro  Gly Glu Pro Ala Ala  Ser Ser Ser 
    1280                 1285                 1290             


Arg Pro  Val Ala Pro Ser Gly  Thr Ala Leu Ser Thr  Thr Ser Ser 
    1295                 1300                 1305             


Lys Leu  Glu Thr Pro Pro Ser  Lys Leu Gly Glu Leu  Leu Phe Pro 
    1310                 1315                 1320             


Ser Ser  Leu Ala Gly Glu Thr  Leu Gly Ser Phe Ser  Gly Leu Arg 
    1325                 1330                 1335             


Val Gly  Gln Ala Asp Asp Ser  Thr Lys Pro Thr Asn  Lys Ala Ser 
    1340                 1345                 1350             


Ser Thr  Ser Leu Thr Ser Thr  Gln Pro Thr Lys Thr  Ser Gly Val 
    1355                 1360                 1365             


Pro Ser  Gly Phe Asn Phe Thr  Ala Pro Pro Val Leu  Gly Lys His 
    1370                 1375                 1380             


Thr Glu  Pro Pro Val Thr Ser  Ser Ala Thr Thr Thr  Ser Val Ala 
    1385                 1390                 1395             


Pro Pro  Ala Ala Thr Ser Thr  Ser Ser Thr Ala Val  Phe Gly Ser 
    1400                 1405                 1410             


Leu Pro  Val Thr Ser Ala Gly  Ser Ser Gly Val Ile  Ser Phe Gly 
    1415                 1420                 1425             


Gly Thr  Ser Leu Ser Ala Gly  Lys Thr Ser Phe Ser  Phe Gly Ser 
    1430                 1435                 1440             


Gln Gln  Thr Asn Ser Thr Val  Pro Pro Ser Ala Pro  Pro Pro Thr 
    1445                 1450                 1455             


Thr Ala  Ala Thr Pro Leu Pro  Thr Ser Phe Pro Thr  Leu Ser Phe 
    1460                 1465                 1470             


Gly Ser  Leu Leu Ser Ser Ala  Thr Thr Pro Ser Leu  Pro Met Ser 
    1475                 1480                 1485             


Ala Gly  Arg Ser Thr Glu Glu  Ala Thr Ser Ser Ala  Leu Pro Glu 
    1490                 1495                 1500             


Lys Pro  Gly Asp Ser Glu Val  Ser Ala Ser Ala Ala  Ser Leu Leu 
    1505                 1510                 1515             


Glu Glu  Gln Gln Ser Ala Gln  Leu Pro Gln Ala Pro  Pro Gln Thr 
    1520                 1525                 1530             


Ser Asp  Ser Val Lys Lys Glu  Pro Val Leu Ala Gln  Pro Ala Val 
    1535                 1540                 1545             


Ser Asn  Ser Gly Thr Ala Ala  Ser Ser Thr Ser Leu  Val Ala Leu 
    1550                 1555                 1560             


Ser Ala  Glu Ala Thr Pro Ala  Thr Thr Gly Val Pro  Asp Ala Arg 
    1565                 1570                 1575             


Thr Glu  Ala Val Pro Pro Ala  Ser Ser Phe Ser Val  Pro Gly Gln 
    1580                 1585                 1590             


Thr Ala  Val Thr Ala Ala Ala  Ile Ser Ser Ala Gly  Pro Val Ala 
    1595                 1600                 1605             


Val Glu  Thr Ser Ser Thr Pro  Ile Ala Ser Ser Thr  Thr Ser Ile 
    1610                 1615                 1620             


Val Ala  Pro Gly Pro Ser Ala  Glu Ala Ala Ala Phe  Gly Thr Val 
    1625                 1630                 1635             


Thr Ser  Gly Ser Ser Val Phe  Ala Gln Pro Pro Ala  Ala Ser Ser 
    1640                 1645                 1650             


Ser Ser  Ala Phe Asn Gln Leu  Thr Asn Asn Thr Ala  Thr Ala Pro 
    1655                 1660                 1665             


Ser Ala  Thr Pro Val Phe Gly  Gln Val Ala Ala Ser  Thr Ala Pro 
    1670                 1675                 1680             


Ser Leu  Phe Gly Gln Gln Thr  Gly Ser Thr Ala Ser  Thr Ala Ala 
    1685                 1690                 1695             


Ala Thr  Pro Gln Val Ser Ser  Ser Gly Phe Ser Ser  Pro Ala Phe 
    1700                 1705                 1710             


Gly Thr  Thr Ala Pro Gly Val  Phe Gly Gln Thr Thr  Phe Gly Gln 
    1715                 1720                 1725             


Ala Ser  Val Phe Gly Gln Ser  Ala Ser Ser Ala Ala  Ser Val Phe 
    1730                 1735                 1740             


Ser Phe  Ser Gln Pro Gly Phe  Ser Ser Val Pro Ala  Phe Gly Gln 
    1745                 1750                 1755             


Pro Ala  Ser Ser Thr Pro Thr  Ser Thr Ser Gly Ser  Val Phe Gly 
    1760                 1765                 1770             


Ala Ala  Ser Ser Thr Ser Ser  Ser Ser Ser Phe Ser  Phe Gly Gln 
    1775                 1780                 1785             


Ser Ser  Pro Asn Thr Gly Gly  Gly Leu Phe Gly Gln  Ser Asn Ala 
    1790                 1795                 1800             


Pro Ala  Phe Gly Gln Ser Pro  Gly Phe Gly Gln Gly  Gly Ser Val 
    1805                 1810                 1815             


Phe Gly  Gly Thr Ser Ala Ala  Thr Thr Thr Ala Ala  Thr Ser Gly 
    1820                 1825                 1830             


Phe Ser  Phe Cys Gln Ala Ser  Gly Phe Gly Ser Ser  Asn Thr Gly 
    1835                 1840                 1845             


Ser Val  Phe Gly Gln Ala Ala  Ser Thr Gly Gly Ile  Val Phe Gly 
    1850                 1855                 1860             


Gln Gln  Ser Ser Ser Ser Ser  Gly Ser Val Phe Gly  Ser Gly Asn 
    1865                 1870                 1875             


Thr Gly  Arg Gly Gly Gly Phe  Phe Ser Gly Leu Gly  Gly Lys Pro 
    1880                 1885                 1890             


Ser Gln  Asp Ala Ala Asn Lys  Asn Pro Phe Ser Ser  Ala Ser Gly 
    1895                 1900                 1905             


Gly Phe  Gly Ser Thr Ala Thr  Ser Asn Thr Ser Asn  Leu Phe Gly 
    1910                 1915                 1920             


Asn Ser  Gly Ala Lys Thr Phe  Gly Gly Phe Ala Ser  Ser Ser Phe 
    1925                 1930                 1935             


Gly Glu  Gln Lys Pro Thr Gly  Thr Phe Ser Ser Gly  Gly Gly Ser 
    1940                 1945                 1950             


Val Ala  Ser Gln Gly Phe Gly  Phe Ser Ser Pro Asn  Lys Thr Gly 
    1955                 1960                 1965             


Gly Phe  Gly Ala Ala Pro Val  Phe Gly Ser Pro Pro  Thr Phe Gly 
    1970                 1975                 1980             


Gly Ser  Pro Gly Phe Gly Gly  Val Pro Ala Phe Gly  Ser Ala Pro 
    1985                 1990                 1995             


Ala Phe  Thr Ser Pro Leu Gly  Ser Thr Gly Gly Lys  Val Phe Gly 
    2000                 2005                 2010             


Glu Gly  Thr Ala Ala Ala Ser  Ala Gly Gly Phe Gly  Phe Gly Ser 
    2015                 2020                 2025             


Ser Ser  Asn Thr Thr Ser Phe  Gly Thr Leu Ala Ser  Gln Asn Ala 
    2030                 2035                 2040             


Pro Thr  Phe Gly Ser Leu Ser  Gln Gln Thr Ser Gly  Phe Gly Thr 
    2045                 2050                 2055             


Gln Ser  Ser Gly Phe Ser Gly  Phe Gly Ser Gly Thr  Gly Gly Phe 
    2060                 2065                 2070             


Ser Phe  Gly Ser Asn Asn Ser  Ser Val Gln Gly Phe  Gly Gly Trp 
    2075                 2080                 2085             


Arg Ser  
    2090 


<210>  9689
<211>  2080
<212>  PRT
<213>  Homo Sapiens

<400>  9689

Met Gly Asp Glu Met Asp Ala Met Ile Pro Glu Arg Glu Met Lys Asp 
1               5                   10                  15      


Phe Gln Phe Arg Ala Leu Lys Lys Val Arg Ile Phe Asp Ser Pro Glu 
            20                  25                  30          


Glu Leu Pro Lys Glu Arg Ser Ser Leu Leu Ala Val Ser Asn Lys Tyr 
        35                  40                  45              


Gly Leu Val Phe Ala Gly Gly Ala Ser Gly Leu Gln Ile Phe Pro Thr 
    50                  55                  60                  


Lys Asn Leu Leu Ile Gln Asn Lys Pro Gly Asp Asp Pro Asn Lys Ile 
65                  70                  75                  80  


Val Asp Lys Val Gln Gly Leu Leu Val Pro Met Lys Phe Pro Ile His 
                85                  90                  95      


His Leu Ala Leu Ser Cys Asp Asn Leu Thr Leu Ser Ala Cys Met Met 
            100                 105                 110         


Ser Ser Glu Tyr Gly Ser Ile Ile Ala Phe Phe Asp Val Arg Thr Phe 
        115                 120                 125             


Ser Asn Glu Ala Lys Gln Gln Lys Arg Pro Phe Ala Tyr His Lys Leu 
    130                 135                 140                 


Leu Lys Asp Ala Gly Gly Met Val Ile Asp Met Lys Trp Asn Pro Thr 
145                 150                 155                 160 


Val Pro Ser Met Val Ala Val Cys Leu Ala Asp Gly Ser Ile Ala Val 
                165                 170                 175     


Leu Gln Val Thr Glu Thr Val Lys Val Cys Ala Thr Leu Pro Ser Thr 
            180                 185                 190         


Val Ala Val Thr Ser Val Cys Trp Ser Pro Lys Gly Lys Gln Leu Ala 
        195                 200                 205             


Val Gly Lys Gln Asn Gly Thr Val Val Gln Tyr Leu Pro Thr Leu Gln 
    210                 215                 220                 


Glu Lys Lys Val Ile Pro Cys Pro Pro Phe Tyr Glu Ser Asp His Pro 
225                 230                 235                 240 


Val Arg Val Leu Asp Val Leu Trp Ile Gly Thr Tyr Val Phe Ala Ile 
                245                 250                 255     


Val Tyr Ala Ala Ala Asp Gly Thr Leu Glu Thr Ser Pro Asp Val Val 
            260                 265                 270         


Met Ala Leu Leu Pro Lys Lys Glu Glu Lys His Pro Glu Ile Phe Val 
        275                 280                 285             


Asn Phe Met Glu Pro Cys Tyr Gly Ser Cys Thr Glu Arg Gln His His 
    290                 295                 300                 


Tyr Tyr Leu Ser Tyr Ile Glu Glu Trp Asp Leu Val Leu Ala Ala Ser 
305                 310                 315                 320 


Ala Ala Ser Thr Glu Val Ser Ile Leu Ala Arg Gln Ser Asp Gln Ile 
                325                 330                 335     


Asn Trp Glu Ser Trp Leu Leu Glu Asp Ser Ser Arg Ala Glu Leu Pro 
            340                 345                 350         


Val Thr Asp Lys Ser Asp Asp Ser Leu Pro Met Gly Val Val Val Asp 
        355                 360                 365             


Tyr Thr Asn Gln Val Glu Ile Thr Ile Ser Asp Glu Lys Thr Leu Pro 
    370                 375                 380                 


Pro Ala Pro Val Leu Met Leu Leu Ser Thr Asp Gly Val Leu Cys Pro 
385                 390                 395                 400 


Phe Tyr Met Ile Asn Gln Asn Pro Gly Val Lys Ser Leu Ile Lys Thr 
                405                 410                 415     


Pro Glu Arg Leu Ser Leu Glu Gly Glu Arg Gln Pro Lys Ser Pro Gly 
            420                 425                 430         


Ser Thr Pro Thr Thr Pro Thr Ser Ser Gln Ala Pro Gln Lys Leu Asp 
        435                 440                 445             


Ala Ser Ala Ala Ala Ala Pro Ala Ser Leu Pro Pro Ser Ser Pro Ala 
    450                 455                 460                 


Ala Pro Ile Ala Thr Phe Ser Leu Leu Pro Ala Gly Gly Ala Pro Thr 
465                 470                 475                 480 


Val Phe Ser Phe Gly Ser Ser Ser Leu Lys Ser Ser Ala Thr Val Thr 
                485                 490                 495     


Gly Glu Pro Pro Ser Tyr Ser Ser Gly Ser Asp Ser Ser Lys Ala Ala 
            500                 505                 510         


Pro Gly Pro Gly Pro Ser Thr Phe Ser Phe Val Pro Pro Ser Lys Ala 
        515                 520                 525             


Ser Leu Ala Pro Thr Pro Ala Ala Ser Pro Val Ala Pro Ser Ala Ala 
    530                 535                 540                 


Ser Phe Ser Phe Gly Ser Ser Gly Phe Lys Pro Thr Leu Glu Ser Thr 
545                 550                 555                 560 


Pro Val Pro Ser Val Ser Ala Pro Asn Ile Ala Met Lys Pro Ser Phe 
                565                 570                 575     


Pro Pro Ser Thr Ser Ala Val Lys Val Asn Leu Ser Glu Asn Ser Ser 
            580                 585                 590         


Gln Ser Ala Pro Pro Met Ser Pro Phe Ser Ser Ala Ser Lys Pro Ala 
        595                 600                 605             


Ala Ser Gly Pro Leu Ser His Pro Thr Pro Leu Ser Ala Pro Pro Ser 
    610                 615                 620                 


Ser Val Pro Leu Lys Ser Ser Val Leu Pro Ser Pro Ser Ala Gly Arg 
625                 630                 635                 640 


Ser Ala Gln Gly Ser Ser Ser Pro Val Pro Ser Met Val Gln Lys Ser 
                645                 650                 655     


Pro Arg Ile Thr Pro Pro Ala Ala Lys Pro Gly Ser Pro Gln Ala Lys 
            660                 665                 670         


Ser Leu Gln Pro Ala Val Ala Glu Lys Gln Gly His Gln Trp Lys Asp 
        675                 680                 685             


Ser Asp Pro Val Met Ala Gly Ile Gly Glu Glu Ile Ala His Phe Gln 
    690                 695                 700                 


Lys Glu Leu Glu Glu Leu Lys Ala Arg Thr Ser Lys Ala Cys Phe Gln 
705                 710                 715                 720 


Val Gly Thr Ser Glu Glu Met Lys Met Leu Arg Thr Glu Ser Asp Asp 
                725                 730                 735     


Leu His Thr Phe Leu Leu Glu Ile Lys Glu Thr Thr Glu Ser Leu His 
            740                 745                 750         


Gly Asp Ile Ser Ser Leu Lys Thr Thr Leu Leu Glu Gly Phe Ala Gly 
        755                 760                 765             


Val Glu Glu Ala Arg Glu Gln Asn Glu Arg Asn Arg Asp Ser Gly Tyr 
    770                 775                 780                 


Leu His Leu Leu Tyr Lys Arg Pro Leu Asp Pro Lys Ser Glu Ala Gln 
785                 790                 795                 800 


Leu Gln Glu Ile Arg Arg Leu His Gln Tyr Val Lys Phe Ala Val Gln 
                805                 810                 815     


Asp Val Asn Asp Val Leu Asp Leu Glu Trp Asp Gln His Leu Glu Gln 
            820                 825                 830         


Lys Lys Lys Gln Arg His Leu Leu Val Pro Glu Arg Glu Thr Leu Phe 
        835                 840                 845             


Asn Thr Leu Ala Asn Asn Arg Glu Ile Ile Asn Gln Gln Arg Lys Arg 
    850                 855                 860                 


Leu Asn His Leu Val Asp Ser Leu Gln Gln Leu Arg Leu Tyr Lys Gln 
865                 870                 875                 880 


Thr Ser Leu Trp Ser Leu Ser Ser Ala Val Pro Ser Gln Ser Ser Ile 
                885                 890                 895     


His Ser Phe Asp Ser Asp Leu Glu Ser Leu Cys Asn Ala Leu Leu Lys 
            900                 905                 910         


Thr Thr Ile Glu Ser His Thr Lys Ser Leu Pro Lys Val Pro Ala Lys 
        915                 920                 925             


Leu Ser Pro Met Lys Gln Ala Gln Leu Arg Asn Phe Leu Ala Lys Arg 
    930                 935                 940                 


Lys Thr Pro Pro Val Arg Ser Thr Ala Pro Ala Ser Leu Ser Arg Ser 
945                 950                 955                 960 


Ala Phe Leu Ser Gln Arg Tyr Tyr Glu Asp Leu Asp Glu Val Ser Ser 
                965                 970                 975     


Thr Ser Ser Val Ser Gln Ser Leu Glu Ser Glu Asp Ala Arg Thr Ser 
            980                 985                 990         


Cys Lys Asp Asp Glu Ala Val Val  Gln Ala Pro Arg His  Ala Pro Val 
        995                 1000                 1005             


Val Arg  Thr Pro Ser Ile Gln  Pro Ser Leu Leu Pro  His Ala Ala 
    1010                 1015                 1020             


Pro Phe  Ala Lys Ser His Leu  Val His Gly Ser Ser  Pro Gly Val 
    1025                 1030                 1035             


Met Gly  Thr Ser Val Ala Thr  Ser Ala Ser Lys Ile  Ile Pro Gln 
    1040                 1045                 1050             


Gly Ala  Asp Ser Thr Met Leu  Ala Thr Lys Thr Val  Lys His Gly 
    1055                 1060                 1065             


Ala Pro  Ser Pro Ser His Pro  Ile Ser Ala Pro Gln  Ala Ala Ala 
    1070                 1075                 1080             


Ala Ala  Ala Leu Arg Arg Gln  Met Ala Ser Gln Ala  Pro Ala Val 
    1085                 1090                 1095             


Asn Thr  Leu Thr Glu Ser Thr  Leu Lys Asn Val Pro  Gln Val Val 
    1100                 1105                 1110             


Asn Val  Gln Glu Leu Lys Asn  Asn Pro Ala Thr Pro  Ser Thr Ala 
    1115                 1120                 1125             


Met Gly  Ser Ser Val Pro Tyr  Ser Thr Ala Lys Thr  Pro His Pro 
    1130                 1135                 1140             


Val Leu  Thr Pro Val Ala Ala  Asn Gln Ala Lys Gln  Gly Ser Leu 
    1145                 1150                 1155             


Ile Asn  Ser Leu Lys Pro Ser  Gly Pro Thr Pro Ala  Ser Gly Gln 
    1160                 1165                 1170             


Leu Ser  Ser Gly Asp Lys Ala  Ser Gly Thr Ala Lys  Ile Glu Thr 
    1175                 1180                 1185             


Ala Val  Thr Ser Thr Pro Ser  Ala Ser Gly Gln Phe  Ser Lys Pro 
    1190                 1195                 1200             


Phe Ser  Phe Ser Pro Ser Gly  Thr Gly Phe Asn Phe  Gly Ile Ile 
    1205                 1210                 1215             


Thr Pro  Thr Pro Ser Ser Asn  Phe Thr Ala Ala Gln  Gly Ala Thr 
    1220                 1225                 1230             


Pro Ser  Thr Lys Glu Ser Ser  Gln Pro Asp Ala Phe  Ser Ser Gly 
    1235                 1240                 1245             


Gly Gly  Ser Lys Pro Ser Tyr  Glu Ala Ile Pro Glu  Ser Ser Pro 
    1250                 1255                 1260             


Pro Ser  Gly Ile Thr Ser Ala  Ser Asn Thr Thr Pro  Gly Glu Pro 
    1265                 1270                 1275             


Ala Ala  Ser Ser Ser Arg Pro  Val Ala Pro Ser Gly  Thr Ala Leu 
    1280                 1285                 1290             


Ser Thr  Thr Ser Ser Lys Leu  Glu Thr Pro Pro Ser  Lys Leu Gly 
    1295                 1300                 1305             


Glu Leu  Leu Phe Pro Ser Ser  Leu Ala Gly Glu Thr  Leu Gly Ser 
    1310                 1315                 1320             


Phe Ser  Gly Leu Arg Val Gly  Gln Ala Asp Asp Ser  Thr Lys Pro 
    1325                 1330                 1335             


Thr Asn  Lys Ala Ser Ser Thr  Ser Leu Thr Ser Thr  Gln Pro Thr 
    1340                 1345                 1350             


Lys Thr  Ser Gly Val Pro Ser  Gly Phe Asn Phe Thr  Ala Pro Pro 
    1355                 1360                 1365             


Val Leu  Gly Lys His Thr Glu  Pro Pro Val Thr Ser  Ser Ala Thr 
    1370                 1375                 1380             


Thr Thr  Ser Val Ala Pro Pro  Ala Ala Thr Ser Thr  Ser Ser Thr 
    1385                 1390                 1395             


Ala Val  Phe Gly Ser Leu Pro  Val Thr Ser Ala Gly  Ser Ser Gly 
    1400                 1405                 1410             


Val Ile  Ser Phe Gly Gly Thr  Ser Leu Ser Ala Gly  Lys Thr Ser 
    1415                 1420                 1425             


Phe Ser  Phe Gly Ser Gln Gln  Thr Asn Ser Thr Val  Pro Pro Ser 
    1430                 1435                 1440             


Ala Pro  Pro Pro Thr Thr Ala  Ala Thr Pro Leu Pro  Thr Ser Phe 
    1445                 1450                 1455             


Pro Thr  Leu Ser Phe Gly Ser  Leu Leu Ser Ser Ala  Thr Thr Pro 
    1460                 1465                 1470             


Ser Leu  Pro Met Ser Ala Gly  Arg Ser Thr Glu Glu  Ala Thr Ser 
    1475                 1480                 1485             


Ser Ala  Leu Pro Glu Lys Pro  Gly Asp Ser Glu Val  Ser Ala Ser 
    1490                 1495                 1500             


Ala Ala  Ser Leu Leu Glu Glu  Gln Gln Ser Ala Gln  Leu Pro Gln 
    1505                 1510                 1515             


Ala Pro  Pro Gln Thr Ser Asp  Ser Val Lys Lys Glu  Pro Val Leu 
    1520                 1525                 1530             


Ala Gln  Pro Ala Val Ser Asn  Ser Gly Thr Ala Ala  Ser Ser Thr 
    1535                 1540                 1545             


Ser Leu  Val Ala Leu Ser Ala  Glu Ala Thr Pro Ala  Thr Thr Gly 
    1550                 1555                 1560             


Val Pro  Asp Ala Arg Thr Glu  Ala Val Pro Pro Ala  Ser Ser Phe 
    1565                 1570                 1575             


Ser Val  Pro Gly Gln Thr Ala  Val Thr Ala Ala Ala  Ile Ser Ser 
    1580                 1585                 1590             


Ala Gly  Pro Val Ala Val Glu  Thr Ser Ser Thr Pro  Ile Ala Ser 
    1595                 1600                 1605             


Ser Thr  Thr Ser Ile Val Ala  Pro Gly Pro Ser Ala  Glu Ala Ala 
    1610                 1615                 1620             


Ala Phe  Gly Thr Val Thr Ser  Gly Ser Ser Val Phe  Ala Gln Pro 
    1625                 1630                 1635             


Pro Ala  Ala Ser Ser Ser Ser  Ala Phe Asn Gln Leu  Thr Asn Asn 
    1640                 1645                 1650             


Thr Ala  Thr Ala Pro Ser Ala  Thr Pro Val Phe Gly  Gln Val Ala 
    1655                 1660                 1665             


Ala Ser  Thr Ala Pro Ser Leu  Phe Gly Gln Gln Thr  Gly Ser Thr 
    1670                 1675                 1680             


Ala Ser  Thr Ala Ala Ala Thr  Pro Gln Val Ser Ser  Ser Gly Phe 
    1685                 1690                 1695             


Ser Ser  Pro Ala Phe Gly Thr  Thr Ala Pro Gly Val  Phe Gly Gln 
    1700                 1705                 1710             


Thr Thr  Phe Gly Gln Ala Ser  Val Phe Gly Gln Ser  Ala Ser Ser 
    1715                 1720                 1725             


Ala Ala  Ser Val Phe Ser Phe  Ser Gln Pro Gly Phe  Ser Ser Val 
    1730                 1735                 1740             


Pro Ala  Phe Gly Gln Pro Ala  Ser Ser Thr Pro Thr  Ser Thr Ser 
    1745                 1750                 1755             


Gly Ser  Val Phe Gly Ala Ala  Ser Ser Thr Ser Ser  Ser Ser Ser 
    1760                 1765                 1770             


Phe Ser  Phe Gly Gln Ser Ser  Pro Asn Thr Gly Gly  Gly Leu Phe 
    1775                 1780                 1785             


Gly Gln  Ser Asn Ala Pro Ala  Phe Gly Gln Ser Pro  Gly Phe Gly 
    1790                 1795                 1800             


Gln Gly  Gly Ser Val Phe Gly  Gly Thr Ser Ala Ala  Thr Thr Thr 
    1805                 1810                 1815             


Ala Ala  Thr Ser Gly Phe Ser  Phe Cys Gln Ala Ser  Gly Phe Gly 
    1820                 1825                 1830             


Ser Ser  Asn Thr Gly Ser Val  Phe Gly Gln Ala Ala  Ser Thr Gly 
    1835                 1840                 1845             


Gly Ile  Val Phe Gly Gln Gln  Ser Ser Ser Ser Ser  Gly Ser Val 
    1850                 1855                 1860             


Phe Gly  Ser Gly Asn Thr Gly  Arg Gly Gly Gly Phe  Phe Ser Gly 
    1865                 1870                 1875             


Leu Gly  Gly Lys Pro Ser Gln  Asp Ala Ala Asn Lys  Asn Pro Phe 
    1880                 1885                 1890             


Ser Ser  Ala Ser Gly Gly Phe  Gly Ser Thr Ala Thr  Ser Asn Thr 
    1895                 1900                 1905             


Ser Asn  Leu Phe Gly Asn Ser  Gly Ala Lys Thr Phe  Gly Gly Phe 
    1910                 1915                 1920             


Ala Ser  Ser Ser Phe Gly Glu  Gln Lys Pro Thr Gly  Thr Phe Ser 
    1925                 1930                 1935             


Ser Gly  Gly Gly Ser Val Ala  Ser Gln Gly Phe Gly  Phe Ser Ser 
    1940                 1945                 1950             


Pro Asn  Lys Thr Gly Gly Phe  Gly Ala Ala Pro Val  Phe Gly Ser 
    1955                 1960                 1965             


Pro Pro  Thr Phe Gly Gly Ser  Pro Gly Phe Gly Gly  Val Pro Ala 
    1970                 1975                 1980             


Phe Gly  Ser Ala Pro Ala Phe  Thr Ser Pro Leu Gly  Ser Thr Gly 
    1985                 1990                 1995             


Gly Lys  Val Phe Gly Glu Gly  Thr Ala Ala Ala Ser  Ala Gly Gly 
    2000                 2005                 2010             


Phe Gly  Phe Gly Ser Ser Ser  Asn Thr Thr Ser Phe  Gly Thr Leu 
    2015                 2020                 2025             


Ala Ser  Gln Asn Ala Pro Thr  Phe Gly Ser Leu Ser  Gln Gln Thr 
    2030                 2035                 2040             


Ser Gly  Phe Gly Thr Gln Ser  Ser Gly Phe Ser Gly  Phe Gly Ser 
    2045                 2050                 2055             


Gly Thr  Gly Gly Phe Ser Phe  Gly Ser Asn Asn Ser  Ser Val Gln 
    2060                 2065                 2070             


Gly Phe  Gly Gly Trp Arg Ser  
    2075                 2080 


<210>  9690
<211>  52
<212>  PRT
<213>  Homo Sapiens

<400>  9690

Met Lys Phe Pro Ile His His Leu Ala Leu Ser Cys Asp Asn Leu Thr 
1               5                   10                  15      


Leu Ser Ala Cys Met Met Ser Ser Glu Tyr Gly Ser Ile Ile Ala Phe 
            20                  25                  30          


Phe Asp Val Arg Thr Phe Ser Asn Glu Ala Lys Gln Gln Lys Arg Pro 
        35                  40                  45              


Phe Ala Tyr His 
    50          


<210>  9691
<211>  1519
<212>  PRT
<213>  Homo Sapiens

<400>  9691

Met Lys Pro Ser Phe Pro Pro Ser Thr Ser Ala Val Lys Val Asn Leu 
1               5                   10                  15      


Ser Glu Lys Phe Thr Ala Ala Ala Thr Ser Thr Pro Val Ser Ser Ser 
            20                  25                  30          


Gln Ser Ala Pro Pro Met Ser Pro Phe Ser Ser Ala Ser Lys Pro Ala 
        35                  40                  45              


Ala Ser Gly Pro Leu Ser His Pro Thr Pro Leu Ser Ala Pro Pro Ser 
    50                  55                  60                  


Ser Val Pro Leu Lys Ser Ser Val Leu Pro Ser Pro Ser Gly Arg Ser 
65                  70                  75                  80  


Ala Gln Gly Ser Ser Ser Pro Val Pro Ser Met Val Gln Lys Ser Pro 
                85                  90                  95      


Arg Ile Thr Pro Pro Ala Ala Lys Pro Gly Ser Pro Gln Ala Lys Ser 
            100                 105                 110         


Leu Gln Pro Ala Val Ala Glu Lys Gln Gly His Gln Trp Lys Asp Ser 
        115                 120                 125             


Asp Pro Val Met Ala Gly Ile Gly Glu Glu Ile Ala His Phe Gln Lys 
    130                 135                 140                 


Glu Leu Glu Glu Leu Lys Ala Arg Thr Ser Lys Ala Cys Phe Gln Val 
145                 150                 155                 160 


Gly Thr Ser Glu Glu Met Lys Met Leu Arg Thr Glu Ser Asp Asp Leu 
                165                 170                 175     


His Thr Phe Leu Leu Glu Ile Lys Glu Thr Thr Glu Ser Leu His Gly 
            180                 185                 190         


Asp Ile Ser Ser Leu Lys Thr Thr Leu Leu Glu Gly Phe Ala Gly Val 
        195                 200                 205             


Glu Glu Ala Arg Glu Gln Asn Glu Arg Asn Arg Asp Ser Gly Tyr Leu 
    210                 215                 220                 


His Leu Leu Tyr Lys Arg Pro Leu Asp Pro Lys Ser Glu Ala Gln Leu 
225                 230                 235                 240 


Gln Glu Ile Arg Arg Leu His Gln Tyr Val Lys Phe Ala Val Gln Asp 
                245                 250                 255     


Val Asn Asp Val Leu Asp Leu Glu Trp Asp Gln His Leu Glu Gln Lys 
            260                 265                 270         


Lys Lys Gln Arg His Leu Leu Val Pro Glu Arg Glu Thr Leu Phe Asn 
        275                 280                 285             


Thr Leu Ala Asn Asn Arg Glu Ile Ile Asn Gln Gln Arg Lys Arg Leu 
    290                 295                 300                 


Asn His Leu Val Asp Ser Leu Gln Gln Leu Arg Leu Tyr Lys Gln Thr 
305                 310                 315                 320 


Ser Leu Trp Ser Leu Ser Ser Ala Val Pro Ser Gln Ser Ser Ile His 
                325                 330                 335     


Ser Phe Asp Ser Asp Leu Glu Ser Leu Cys Asn Ala Leu Leu Lys Thr 
            340                 345                 350         


Thr Ile Glu Ser His Thr Lys Ser Leu Pro Lys Val Pro Ala Lys Leu 
        355                 360                 365             


Ser Pro Met Lys Gln Ala Gln Leu Arg Asn Phe Leu Ala Lys Arg Lys 
    370                 375                 380                 


Thr Pro Pro Val Arg Ser Thr Ala Pro Ala Ser Leu Ser Arg Ser Ala 
385                 390                 395                 400 


Phe Leu Ser Gln Arg Tyr Tyr Glu Asp Leu Asp Glu Val Ser Ser Thr 
                405                 410                 415     


Ser Ser Val Ser Gln Ser Leu Glu Ser Glu Asp Ala Arg Thr Ser Cys 
            420                 425                 430         


Lys Asp Asp Glu Ala Val Val Gln Ala Pro Arg His Ala Pro Val Val 
        435                 440                 445             


Arg Thr Pro Ser Ile Gln Pro Ser Leu Leu Pro His Ala Ala Pro Phe 
    450                 455                 460                 


Ala Lys Ser His Leu Val His Gly Ser Ser Pro Gly Val Met Gly Thr 
465                 470                 475                 480 


Ser Val Ala Thr Ser Ala Ser Lys Ile Ile Pro Gln Gly Ala Asp Ser 
                485                 490                 495     


Thr Met Leu Ala Thr Lys Thr Val Lys His Gly Ala Pro Ser Pro Ser 
            500                 505                 510         


His Pro Ile Ser Ala Pro Gln Ala Ala Ala Ala Ala Ala Leu Arg Arg 
        515                 520                 525             


Gln Met Ala Ser Gln Ala Pro Ala Val Asn Thr Leu Thr Glu Ser Thr 
    530                 535                 540                 


Leu Lys Asn Val Pro Gln Val Val Asn Val Gln Glu Leu Lys Asn Asn 
545                 550                 555                 560 


Pro Ala Thr Pro Ser Thr Ala Met Gly Ser Ser Val Pro Tyr Ser Thr 
                565                 570                 575     


Ala Lys Thr Pro His Pro Val Leu Thr Pro Val Ala Ala Asn Gln Ala 
            580                 585                 590         


Lys Gln Gly Ser Leu Ile Asn Ser Leu Lys Pro Ser Gly Pro Thr Pro 
        595                 600                 605             


Ala Ser Gly Gln Leu Ser Ser Gly Asp Lys Ala Ser Gly Thr Ala Lys 
    610                 615                 620                 


Ile Glu Thr Ala Val Thr Ser Thr Pro Ser Ala Ser Gly Gln Phe Ser 
625                 630                 635                 640 


Lys Pro Phe Ser Phe Ser Pro Ser Gly Thr Gly Phe Asn Phe Gly Ile 
                645                 650                 655     


Ile Thr Pro Thr Pro Ser Ser Asn Phe Thr Ala Ala Gln Gly Ala Thr 
            660                 665                 670         


Pro Ser Thr Lys Glu Ser Ser Gln Pro Asp Ala Phe Ser Ser Gly Gly 
        675                 680                 685             


Gly Ser Lys Pro Ser Tyr Glu Ala Ile Pro Glu Ser Ser Pro Pro Ser 
    690                 695                 700                 


Gly Ile Thr Ser Ala Ser Asn Thr Thr Pro Gly Glu Pro Ala Ala Ser 
705                 710                 715                 720 


Ser Ser Arg Pro Val Ala Pro Ser Gly Thr Ala Leu Ser Thr Thr Ser 
                725                 730                 735     


Ser Lys Leu Glu Thr Pro Pro Ser Lys Leu Gly Glu Leu Leu Phe Pro 
            740                 745                 750         


Ser Ser Leu Ala Gly Glu Thr Leu Gly Ser Phe Ser Gly Leu Arg Val 
        755                 760                 765             


Gly Gln Ala Asp Asp Ser Thr Lys Pro Thr Asn Lys Ala Ser Ser Thr 
    770                 775                 780                 


Ser Leu Thr Ser Thr Gln Pro Thr Lys Thr Ser Gly Val Pro Ser Gly 
785                 790                 795                 800 


Phe Asn Phe Thr Ala Pro Pro Val Leu Gly Lys His Thr Glu Pro Pro 
                805                 810                 815     


Val Thr Ser Ser Ala Thr Thr Thr Ser Val Ala Pro Pro Ala Ala Thr 
            820                 825                 830         


Ser Thr Ser Ser Thr Ala Val Phe Gly Ser Leu Pro Val Thr Ser Ala 
        835                 840                 845             


Gly Ser Ser Gly Val Ile Ser Phe Gly Gly Thr Ser Leu Ser Ala Gly 
    850                 855                 860                 


Lys Thr Ser Phe Ser Phe Gly Ser Gln Gln Thr Asn Ser Thr Val Pro 
865                 870                 875                 880 


Pro Ser Ala Pro Pro Pro Thr Thr Ala Ala Thr Pro Leu Pro Thr Ser 
                885                 890                 895     


Phe Pro Thr Leu Ser Phe Gly Ser Leu Leu Ser Ser Ala Thr Thr Pro 
            900                 905                 910         


Ser Leu Pro Met Ser Ala Gly Arg Ser Thr Glu Glu Ala Thr Ser Ser 
        915                 920                 925             


Ala Leu Pro Glu Lys Pro Gly Asp Ser Glu Val Ser Ala Ser Ala Ala 
    930                 935                 940                 


Ser Leu Leu Glu Glu Gln Gln Ser Ala Gln Leu Pro Gln Ala Pro Pro 
945                 950                 955                 960 


Gln Thr Ser Asp Ser Val Lys Lys Glu Pro Val Leu Ala Gln Pro Ala 
                965                 970                 975     


Val Ser Asn Ser Gly Thr Ala Ala Ser Ser Thr Ser Leu Val Ala Leu 
            980                 985                 990         


Ser Ala Glu Ala Thr Pro Ala Thr  Thr Gly Val Pro Asp  Ala Arg Thr 
        995                 1000                 1005             


Glu Ala  Val Pro Pro Ala Ser  Ser Phe Ser Val Pro  Gly Gln Thr 
    1010                 1015                 1020             


Ala Val  Thr Ala Ala Ala Ile  Ser Ser Ala Gly Pro  Val Ala Val 
    1025                 1030                 1035             


Glu Thr  Ser Ser Thr Pro Ile  Ala Ser Ser Thr Thr  Ser Ile Val 
    1040                 1045                 1050             


Ala Pro  Gly Pro Ser Ala Glu  Ala Ala Ala Phe Gly  Thr Val Thr 
    1055                 1060                 1065             


Ser Gly  Ser Ser Val Phe Ala  Gln Pro Pro Ala Ala  Ser Ser Ser 
    1070                 1075                 1080             


Ser Ala  Phe Asn Gln Leu Thr  Asn Asn Thr Ala Thr  Ala Pro Ser 
    1085                 1090                 1095             


Ala Thr  Pro Val Phe Gly Gln  Val Ala Ala Ser Thr  Ala Pro Ser 
    1100                 1105                 1110             


Leu Phe  Gly Gln Gln Thr Gly  Ser Thr Ala Ser Thr  Ala Ala Ala 
    1115                 1120                 1125             


Thr Pro  Gln Val Ser Ser Ser  Gly Phe Ser Ser Pro  Ala Phe Gly 
    1130                 1135                 1140             


Thr Thr  Ala Pro Gly Val Phe  Gly Gln Thr Thr Phe  Gly Gln Ala 
    1145                 1150                 1155             


Ser Val  Phe Gly Gln Ser Ala  Ser Ser Ala Ala Ser  Val Phe Ser 
    1160                 1165                 1170             


Phe Ser  Gln Pro Gly Phe Ser  Ser Val Pro Ala Phe  Gly Gln Pro 
    1175                 1180                 1185             


Ala Ser  Ser Thr Pro Thr Ser  Thr Ser Gly Ser Val  Phe Gly Ala 
    1190                 1195                 1200             


Ala Ser  Ser Thr Ser Ser Ser  Ser Ser Phe Ser Phe  Gly Gln Ser 
    1205                 1210                 1215             


Ser Pro  Asn Thr Gly Gly Gly  Leu Phe Gly Gln Ser  Asn Ala Pro 
    1220                 1225                 1230             


Ala Phe  Gly Gln Ser Pro Gly  Phe Gly Gln Gly Gly  Ser Val Phe 
    1235                 1240                 1245             


Gly Gly  Thr Ser Ala Ala Thr  Thr Thr Ala Ala Thr  Ser Gly Phe 
    1250                 1255                 1260             


Ser Phe  Cys Gln Ala Ser Gly  Phe Gly Ser Ser Asn  Thr Gly Ser 
    1265                 1270                 1275             


Val Phe  Gly Gln Ala Ala Ser  Thr Gly Gly Ile Val  Phe Gly Gln 
    1280                 1285                 1290             


Gln Ser  Ser Ser Ser Ser Gly  Ser Val Phe Gly Ser  Gly Asn Thr 
    1295                 1300                 1305             


Gly Arg  Gly Gly Gly Phe Phe  Ser Gly Leu Gly Gly  Lys Pro Ser 
    1310                 1315                 1320             


Gln Asp  Ala Ala Asn Lys Asn  Pro Phe Ser Ser Ala  Ser Gly Gly 
    1325                 1330                 1335             


Phe Gly  Ser Thr Ala Thr Ser  Asn Thr Ser Asn Leu  Phe Gly Asn 
    1340                 1345                 1350             


Ser Gly  Ala Lys Thr Phe Gly  Gly Phe Ala Ser Ser  Ser Phe Gly 
    1355                 1360                 1365             


Glu Gln  Lys Pro Thr Gly Thr  Phe Ser Ser Gly Gly  Gly Ser Val 
    1370                 1375                 1380             


Ala Ser  Gln Gly Phe Gly Phe  Ser Ser Pro Asn Lys  Thr Gly Gly 
    1385                 1390                 1395             


Phe Gly  Ala Ala Pro Val Phe  Gly Ser Pro Pro Thr  Phe Gly Gly 
    1400                 1405                 1410             


Ser Pro  Gly Phe Gly Gly Val  Pro Ala Phe Gly Ser  Ala Pro Ala 
    1415                 1420                 1425             


Phe Thr  Ser Pro Leu Gly Ser  Thr Gly Gly Lys Val  Phe Gly Glu 
    1430                 1435                 1440             


Gly Thr  Ala Ala Ala Ser Ala  Gly Gly Phe Gly Phe  Gly Ser Ser 
    1445                 1450                 1455             


Ser Asn  Thr Thr Ser Phe Gly  Thr Leu Ala Ser Gln  Asn Ala Pro 
    1460                 1465                 1470             


Thr Phe  Gly Ser Leu Ser Gln  Gln Thr Ser Gly Phe  Gly Thr Gln 
    1475                 1480                 1485             


Ser Ser  Gly Phe Ser Gly Phe  Gly Ser Gly Thr Gly  Gly Phe Ser 
    1490                 1495                 1500             


Phe Gly  Ser Asn Asn Ser Ser  Val Gln Gly Phe Gly  Gly Trp Arg 
    1505                 1510                 1515             


Ser 
    


<210>  9692
<211>  495
<212>  PRT
<213>  Homo Sapiens

<400>  9692

Met Lys Ser Ser Leu Leu Leu Arg Gly Val His Phe Cys Phe His Leu 
1               5                   10                  15      


Pro Gly Ala Thr Pro Ser Thr Lys Glu Ser Ser Gln Pro Asp Ala Phe 
            20                  25                  30          


Ser Ser Gly Gly Gly Ser Lys Pro Ser Tyr Glu Ala Ile Pro Glu Ser 
        35                  40                  45              


Ser Pro Pro Ser Gly Ile Thr Ser Ala Ser Asn Thr Thr Pro Gly Glu 
    50                  55                  60                  


Pro Ala Ala Ser Ser Ser Arg Pro Val Ala Pro Ser Gly Thr Ala Leu 
65                  70                  75                  80  


Ser Thr Thr Ser Ser Lys Leu Glu Thr Pro Pro Ser Lys Leu Gly Glu 
                85                  90                  95      


Leu Leu Phe Pro Ser Ser Leu Ala Gly Glu Thr Leu Gly Ser Phe Ser 
            100                 105                 110         


Gly Leu Arg Val Gly Gln Ala Asp Asp Ser Thr Lys Pro Thr Asn Lys 
        115                 120                 125             


Ala Ser Ser Thr Ser Leu Thr Ser Thr Gln Pro Thr Lys Thr Ser Gly 
    130                 135                 140                 


Val Pro Ser Gly Phe Asn Phe Thr Ala Pro Pro Val Leu Gly Lys His 
145                 150                 155                 160 


Thr Glu Pro Pro Val Thr Ser Ser Ala Thr Thr Thr Ser Val Ala Pro 
                165                 170                 175     


Pro Ala Ala Thr Ser Thr Ser Ser Thr Ala Val Phe Gly Ser Leu Pro 
            180                 185                 190         


Val Thr Ser Ala Gly Ser Ser Gly Val Ile Ser Phe Gly Gly Thr Ser 
        195                 200                 205             


Leu Ser Ala Gly Lys Thr Ser Phe Ser Phe Gly Ser Gln Gln Thr Asn 
    210                 215                 220                 


Ser Thr Val Pro Pro Ser Ala Pro Pro Pro Thr Thr Ala Ala Thr Pro 
225                 230                 235                 240 


Leu Pro Thr Ser Phe Pro Thr Leu Ser Phe Gly Ser Leu Leu Ser Ser 
                245                 250                 255     


Ala Thr Thr Pro Ser Leu Pro Met Ser Ala Gly Arg Ser Thr Glu Glu 
            260                 265                 270         


Ala Thr Ser Ser Ala Leu Pro Glu Lys Pro Gly Asp Ser Glu Val Ser 
        275                 280                 285             


Ala Ser Ala Ala Ser Leu Leu Glu Glu Gln Gln Ser Ala Gln Leu Pro 
    290                 295                 300                 


Gln Ala Pro Pro Gln Thr Ser Asp Ser Val Lys Lys Glu Pro Val Leu 
305                 310                 315                 320 


Ala Gln Pro Ala Val Ser Asn Ser Gly Thr Ala Ala Ser Ser Thr Ser 
                325                 330                 335     


Leu Val Ala Leu Ser Ala Glu Ala Thr Pro Ala Thr Thr Gly Val Pro 
            340                 345                 350         


Asp Ala Arg Thr Glu Ala Val Pro Pro Ala Ser Ser Phe Ser Val Pro 
        355                 360                 365             


Gly Gln Thr Ala Val Thr Ala Ala Ala Ile Ser Ser Ala Gly Pro Val 
    370                 375                 380                 


Ala Val Glu Thr Ser Ser Thr Pro Ile Ala Ser Ser Thr Thr Ser Ile 
385                 390                 395                 400 


Val Ala Pro Gly Pro Ser Ala Glu Ala Ala Ala Phe Gly Thr Val Thr 
                405                 410                 415     


Ser Gly Ser Ser Val Phe Ala Gln Pro Pro Ala Ala Ser Ser Ser Ser 
            420                 425                 430         


Ala Phe Asn Gln Leu Thr Asn Asn Thr Ala Thr Ala Pro Ser Ala Thr 
        435                 440                 445             


Pro Val Phe Gly Gln Val Ala Ala Ser Thr Ala Pro Ser Leu Phe Gly 
    450                 455                 460                 


Gln Gln Thr Gly Ser Thr Ala Ser Thr Ala Ala Ala Thr Pro Gln Val 
465                 470                 475                 480 


Ser Ser Ser Gly Phe Ser Ser Pro Ala Phe Gly Thr Thr Ala Pro 
                485                 490                 495 


<210>  9693
<211>  916
<212>  PRT
<213>  Homo Sapiens

<400>  9693

Met Lys Ser Ser Leu Leu Leu Arg Gly Val His Phe Cys Phe His Leu 
1               5                   10                  15      


Pro Gly Thr Ala Lys Ile Glu Thr Ala Val Thr Ser Thr Pro Ser Ala 
            20                  25                  30          


Ser Gly Gln Phe Ser Lys Pro Phe Ser Phe Ser Pro Ser Gly Thr Gly 
        35                  40                  45              


Phe Asn Phe Gly Ile Ile Thr Pro Thr Pro Ser Ser Asn Phe Thr Ala 
    50                  55                  60                  


Ala Gln Gly Ala Thr Pro Ser Thr Lys Glu Ser Ser Gln Pro Asp Ala 
65                  70                  75                  80  


Phe Ser Ser Gly Gly Gly Ser Lys Pro Ser Tyr Glu Ala Ile Pro Glu 
                85                  90                  95      


Ser Ser Pro Pro Ser Gly Ile Thr Ser Ala Ser Asn Thr Thr Pro Gly 
            100                 105                 110         


Glu Pro Ala Ala Ser Ser Ser Arg Pro Val Ala Pro Ser Gly Thr Ala 
        115                 120                 125             


Leu Ser Thr Thr Ser Ser Lys Leu Glu Thr Pro Pro Ser Lys Leu Gly 
    130                 135                 140                 


Glu Leu Leu Phe Pro Ser Ser Leu Ala Gly Glu Thr Leu Gly Ser Phe 
145                 150                 155                 160 


Ser Gly Leu Arg Val Gly Gln Ala Asp Asp Ser Thr Lys Pro Thr Asn 
                165                 170                 175     


Lys Ala Ser Ser Thr Ser Leu Thr Ser Thr Gln Pro Thr Lys Thr Ser 
            180                 185                 190         


Gly Val Pro Ser Gly Phe Asn Phe Thr Ala Pro Pro Val Leu Gly Lys 
        195                 200                 205             


His Thr Glu Pro Pro Val Thr Ser Ser Ala Thr Thr Thr Ser Val Ala 
    210                 215                 220                 


Pro Pro Ala Ala Thr Ser Thr Ser Ser Thr Ala Val Phe Gly Ser Leu 
225                 230                 235                 240 


Pro Val Thr Ser Ala Gly Ser Ser Gly Val Ile Ser Phe Gly Gly Thr 
                245                 250                 255     


Ser Leu Ser Ala Gly Lys Thr Ser Phe Ser Phe Gly Ser Gln Gln Thr 
            260                 265                 270         


Asn Ser Thr Val Pro Pro Ser Ala Pro Pro Pro Thr Thr Ala Ala Thr 
        275                 280                 285             


Pro Leu Pro Thr Ser Phe Pro Thr Leu Ser Phe Gly Ser Leu Leu Ser 
    290                 295                 300                 


Ser Ala Thr Thr Pro Ser Leu Pro Met Ser Ala Gly Arg Ser Thr Glu 
305                 310                 315                 320 


Glu Ala Thr Ser Ser Ala Leu Pro Glu Lys Pro Gly Asp Ser Glu Val 
                325                 330                 335     


Ser Ala Ser Ala Ala Ser Leu Leu Glu Glu Gln Gln Ser Ala Gln Leu 
            340                 345                 350         


Pro Gln Ala Pro Pro Gln Thr Ser Asp Ser Val Lys Lys Glu Pro Val 
        355                 360                 365             


Leu Ala Gln Pro Ala Val Ser Asn Ser Gly Thr Ala Ala Ser Ser Thr 
    370                 375                 380                 


Ser Leu Val Ala Leu Ser Ala Glu Ala Thr Pro Ala Thr Thr Gly Val 
385                 390                 395                 400 


Pro Asp Ala Arg Thr Glu Ala Val Pro Pro Ala Ser Ser Phe Ser Val 
                405                 410                 415     


Pro Gly Gln Thr Ala Val Thr Ala Ala Ala Ile Ser Ser Ala Gly Pro 
            420                 425                 430         


Val Ala Val Glu Thr Ser Ser Thr Pro Ile Ala Ser Ser Thr Thr Ser 
        435                 440                 445             


Ile Val Ala Pro Gly Pro Ser Ala Glu Ala Ala Ala Phe Gly Thr Val 
    450                 455                 460                 


Thr Ser Gly Ser Ser Val Phe Ala Gln Pro Pro Ala Ala Ser Ser Ser 
465                 470                 475                 480 


Ser Ala Phe Asn Gln Leu Thr Asn Asn Thr Ala Thr Ala Pro Ser Ala 
                485                 490                 495     


Thr Pro Val Phe Gly Gln Val Ala Ala Ser Thr Ala Pro Ser Leu Phe 
            500                 505                 510         


Gly Gln Gln Thr Gly Ser Thr Ala Ser Thr Ala Ala Ala Thr Pro Gln 
        515                 520                 525             


Val Ser Ser Ser Gly Phe Ser Ser Pro Ala Phe Gly Thr Thr Ala Pro 
    530                 535                 540                 


Gly Val Phe Gly Gln Thr Thr Phe Gly Gln Ala Ser Val Phe Gly Gln 
545                 550                 555                 560 


Ser Ala Ser Ser Ala Ala Ser Val Phe Ser Phe Ser Gln Pro Gly Phe 
                565                 570                 575     


Ser Ser Val Pro Ala Phe Gly Gln Pro Ala Ser Ser Thr Pro Thr Ser 
            580                 585                 590         


Thr Ser Gly Ser Val Phe Gly Ala Ala Ser Ser Thr Ser Ser Ser Ser 
        595                 600                 605             


Ser Phe Ser Phe Gly Gln Ser Ser Pro Asn Thr Gly Gly Gly Leu Phe 
    610                 615                 620                 


Gly Gln Ser Asn Ala Pro Ala Phe Gly Gln Ser Pro Gly Phe Gly Gln 
625                 630                 635                 640 


Gly Gly Ser Val Phe Gly Gly Thr Ser Ala Ala Thr Thr Thr Ala Ala 
                645                 650                 655     


Thr Ser Gly Phe Ser Phe Cys Gln Ala Ser Gly Phe Gly Ser Ser Asn 
            660                 665                 670         


Thr Gly Ser Val Phe Gly Gln Ala Ala Ser Thr Gly Gly Ile Val Phe 
        675                 680                 685             


Gly Gln Gln Ser Ser Ser Ser Ser Gly Ser Val Phe Gly Ser Gly Asn 
    690                 695                 700                 


Thr Gly Arg Gly Gly Gly Phe Phe Ser Gly Leu Gly Gly Lys Pro Ser 
705                 710                 715                 720 


Gln Asp Ala Ala Asn Lys Asn Pro Phe Ser Ser Ala Ser Gly Gly Phe 
                725                 730                 735     


Gly Ser Thr Ala Thr Ser Asn Thr Ser Asn Leu Phe Gly Asn Ser Gly 
            740                 745                 750         


Ala Lys Thr Phe Gly Gly Phe Ala Ser Ser Ser Phe Gly Glu Gln Lys 
        755                 760                 765             


Pro Thr Gly Thr Phe Ser Ser Gly Gly Gly Ser Val Ala Ser Gln Gly 
    770                 775                 780                 


Phe Gly Phe Ser Ser Pro Asn Lys Thr Gly Gly Phe Gly Ala Ala Pro 
785                 790                 795                 800 


Val Phe Gly Ser Pro Pro Thr Phe Gly Gly Ser Pro Gly Phe Gly Gly 
                805                 810                 815     


Val Pro Ala Phe Gly Ser Ala Pro Ala Phe Thr Ser Pro Leu Gly Ser 
            820                 825                 830         


Thr Gly Gly Lys Val Phe Gly Glu Gly Thr Ala Ala Ala Ser Ala Gly 
        835                 840                 845             


Gly Phe Gly Phe Gly Ser Ser Ser Asn Thr Thr Ser Phe Gly Thr Leu 
    850                 855                 860                 


Ala Ser Gln Asn Ala Pro Thr Phe Gly Ser Leu Ser Gln Gln Thr Ser 
865                 870                 875                 880 


Gly Phe Gly Thr Gln Ser Ser Gly Phe Ser Gly Phe Gly Ser Gly Thr 
                885                 890                 895     


Gly Gly Phe Ser Phe Gly Ser Asn Asn Ser Ser Val Gln Gly Phe Gly 
            900                 905                 910         


Gly Trp Arg Ser 
        915     


<210>  9694
<211>  187
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9694

Xaa Ala Arg Gln Ser Asp Gln Ile Asn Trp Glu Ser Trp Leu Leu Glu 
1               5                   10                  15      


Asp Ser Ser Arg Ala Glu Leu Pro Val Thr Asp Lys Ser Asp Asp Ser 
            20                  25                  30          


Leu Pro Met Gly Val Val Val Asp Tyr Thr Asn Gln Val Glu Ile Thr 
        35                  40                  45              


Ile Ser Asp Glu Lys Thr Leu Pro Pro Ala Pro Val Leu Met Leu Leu 
    50                  55                  60                  


Ser Thr Asp Gly Val Leu Cys Pro Phe Tyr Met Ile Asn Gln Asn Pro 
65                  70                  75                  80  


Gly Val Lys Ser Leu Ile Lys Thr Pro Glu Arg Leu Ser Leu Glu Gly 
                85                  90                  95      


Glu Arg Gln Pro Lys Ser Pro Ala Ser Leu Ala Pro Thr Pro Ala Ala 
            100                 105                 110         


Ser Pro Val Ala Pro Ser Ala Ala Ser Phe Ser Phe Gly Ser Ser Gly 
        115                 120                 125             


Phe Lys Pro Thr Leu Glu Ser Thr Pro Val Pro Ser Val Ser Ala Pro 
    130                 135                 140                 


Asn Ile Ala Met Lys Pro Ser Phe Pro Pro Ser Thr Ser Ala Val Lys 
145                 150                 155                 160 


Val Asn Leu Ser Glu Lys Phe Thr Ala Ala Ala Thr Ser Thr Pro Val 
                165                 170                 175     


Ser Ser Ser Gln Ser Ala Pro Pro Met Ser Pro 
            180                 185         


<210>  9695
<211>  145
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9695

Xaa Gly Val Pro Ala Phe Gly Ser Ala Pro Ala Phe Thr Ser Pro Leu 
1               5                   10                  15      


Gly Ser Thr Gly Gly Lys Val Phe Gly Glu Gly Thr Ala Ala Ala Ser 
            20                  25                  30          


Ala Gly Gly Phe Gly Phe Gly Ser Ser Ser Asn Thr Thr Ser Phe Gly 
        35                  40                  45              


Thr Leu Ala Ser Gln Asn Ala Pro Thr Phe Gly Ser Leu Ser Gln Gln 
    50                  55                  60                  


Thr Ser Gly Phe Gly Thr Gln Ser Ser Gly Phe Ser Gly Phe Gly Ser 
65                  70                  75                  80  


Gly Thr Gly Gly Leu Ser Arg Val Leu Val Ala Gly Glu Ala Glu Gly 
                85                  90                  95      


Val Ser Ala Gly Leu Ser Ile Pro Gly Thr Asn Arg Ile Leu Ser Phe 
            100                 105                 110         


Phe Pro Glu Lys Cys Trp Ser Arg Leu Phe Arg Pro Thr Leu Pro Ser 
        115                 120                 125             


Lys His Ile His Pro Glu Arg Asn Asn Arg Asn Gln Asn Ser Gln Gly 
    130                 135                 140                 


Ala 
145 


<210>  9696
<211>  967
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9696

Xaa Lys Thr Pro His Pro Val Leu Thr Pro Val Ala Ala Asn Gln Ala 
1               5                   10                  15      


Lys Gln Gly Ser Leu Ile Asn Ser Leu Lys Pro Ser Gly Pro Thr Pro 
            20                  25                  30          


Ala Ser Gly Gln Leu Ser Ser Gly Asp Lys Ala Ser Gly Thr Ala Lys 
        35                  40                  45              


Ile Glu Thr Ala Val Thr Ser Thr Pro Ser Ala Ser Gly Gln Phe Ser 
    50                  55                  60                  


Lys Pro Phe Ser Phe Ser Pro Ser Gly Thr Gly Phe Asn Phe Gly Ile 
65                  70                  75                  80  


Ile Thr Pro Thr Pro Ser Ser Asn Phe Thr Ala Ala Gln Gly Ala Thr 
                85                  90                  95      


Pro Ser Thr Lys Glu Ser Ser Gln Pro Asp Ala Phe Ser Ser Gly Gly 
            100                 105                 110         


Gly Ser Lys Pro Ser Tyr Glu Ala Ile Pro Glu Ser Ser Pro Pro Ser 
        115                 120                 125             


Gly Ile Thr Ser Ala Ser Asn Thr Thr Pro Gly Glu Pro Ala Ala Ser 
    130                 135                 140                 


Ser Ser Arg Pro Val Ala Pro Ser Gly Thr Ala Leu Ser Thr Thr Ser 
145                 150                 155                 160 


Ser Lys Leu Glu Thr Pro Pro Ser Lys Leu Gly Glu Leu Leu Phe Pro 
                165                 170                 175     


Ser Ser Leu Ala Gly Glu Thr Leu Gly Ser Phe Ser Gly Leu Arg Val 
            180                 185                 190         


Gly Gln Ala Asp Asp Ser Thr Lys Pro Thr Asn Lys Ala Ser Ser Thr 
        195                 200                 205             


Ser Leu Thr Ser Thr Gln Pro Thr Lys Thr Ser Gly Val Pro Ser Gly 
    210                 215                 220                 


Phe Asn Phe Thr Ala Pro Pro Val Leu Gly Lys His Thr Glu Pro Pro 
225                 230                 235                 240 


Val Thr Ser Ser Ala Thr Thr Thr Ser Val Ala Pro Pro Ala Ala Thr 
                245                 250                 255     


Ser Thr Ser Ser Thr Ala Val Phe Gly Ser Leu Pro Val Thr Ser Ala 
            260                 265                 270         


Gly Ser Ser Gly Val Ile Ser Phe Gly Gly Thr Ser Leu Ser Ala Gly 
        275                 280                 285             


Lys Thr Ser Phe Ser Phe Gly Ser Gln Gln Thr Asn Ser Thr Val Pro 
    290                 295                 300                 


Pro Ser Ala Pro Pro Pro Thr Thr Ala Ala Thr Pro Leu Pro Thr Ser 
305                 310                 315                 320 


Phe Pro Thr Leu Ser Phe Gly Ser Leu Leu Ser Ser Ala Thr Thr Pro 
                325                 330                 335     


Ser Leu Pro Met Ser Ala Gly Arg Ser Thr Glu Glu Ala Thr Ser Ser 
            340                 345                 350         


Ala Leu Pro Glu Lys Pro Gly Asp Ser Glu Val Ser Ala Ser Ala Ala 
        355                 360                 365             


Ser Leu Leu Glu Glu Gln Gln Ser Ala Gln Leu Pro Gln Ala Pro Pro 
    370                 375                 380                 


Gln Thr Ser Asp Ser Val Lys Lys Glu Pro Val Leu Ala Gln Pro Ala 
385                 390                 395                 400 


Val Ser Asn Ser Gly Thr Ala Ala Ser Ser Thr Ser Leu Val Ala Leu 
                405                 410                 415     


Ser Ala Glu Ala Thr Pro Ala Thr Thr Gly Val Pro Asp Ala Arg Thr 
            420                 425                 430         


Glu Ala Val Pro Pro Ala Ser Ser Phe Ser Val Pro Gly Gln Thr Ala 
        435                 440                 445             


Val Thr Ala Ala Ala Ile Ser Ser Ala Gly Pro Val Ala Val Glu Thr 
    450                 455                 460                 


Ser Ser Thr Pro Ile Ala Ser Ser Thr Thr Ser Ile Val Ala Pro Gly 
465                 470                 475                 480 


Pro Ser Ala Glu Ala Ala Ala Phe Gly Thr Val Thr Ser Gly Ser Ser 
                485                 490                 495     


Val Phe Ala Gln Pro Pro Ala Ala Ser Ser Ser Ser Ala Phe Asn Gln 
            500                 505                 510         


Leu Thr Asn Asn Thr Ala Thr Ala Pro Ser Ala Thr Pro Val Phe Gly 
        515                 520                 525             


Gln Val Ala Ala Ser Thr Ala Pro Ser Leu Phe Gly Gln Gln Thr Gly 
    530                 535                 540                 


Ser Thr Ala Ser Thr Ala Ala Ala Thr Pro Gln Val Ser Ser Ser Gly 
545                 550                 555                 560 


Phe Ser Ser Pro Ala Phe Gly Thr Thr Ala Pro Gly Val Phe Gly Gln 
                565                 570                 575     


Thr Thr Phe Gly Gln Ala Ser Val Phe Gly Gln Ser Ala Ser Ser Ala 
            580                 585                 590         


Ala Ser Val Phe Ser Phe Ser Gln Pro Gly Phe Ser Ser Val Pro Ala 
        595                 600                 605             


Phe Gly Gln Pro Ala Ser Ser Thr Pro Thr Ser Thr Ser Gly Ser Val 
    610                 615                 620                 


Phe Gly Ala Ala Ser Ser Thr Ser Ser Ser Ser Ser Phe Ser Phe Gly 
625                 630                 635                 640 


Gln Ser Ser Pro Asn Thr Gly Gly Gly Leu Phe Gly Gln Ser Asn Ala 
                645                 650                 655     


Pro Ala Phe Gly Gln Ser Pro Gly Phe Gly Gln Gly Gly Ser Val Phe 
            660                 665                 670         


Gly Gly Thr Ser Ala Ala Thr Thr Thr Ala Ala Thr Ser Gly Phe Ser 
        675                 680                 685             


Phe Cys Gln Ala Ser Gly Phe Gly Ser Ser Asn Thr Gly Ser Val Phe 
    690                 695                 700                 


Gly Gln Ala Ala Ser Thr Gly Gly Ile Val Phe Gly Gln Gln Ser Ser 
705                 710                 715                 720 


Ser Ser Ser Gly Ser Val Phe Gly Ser Gly Asn Thr Gly Arg Gly Gly 
                725                 730                 735     


Gly Phe Phe Ser Gly Leu Gly Gly Lys Pro Ser Gln Asp Ala Ala Asn 
            740                 745                 750         


Lys Asn Pro Phe Ser Ser Ala Ser Gly Gly Phe Gly Ser Thr Ala Thr 
        755                 760                 765             


Ser Asn Thr Ser Asn Leu Phe Gly Asn Ser Gly Ala Lys Thr Phe Gly 
    770                 775                 780                 


Gly Phe Ala Ser Ser Ser Phe Gly Glu Gln Lys Pro Thr Gly Thr Phe 
785                 790                 795                 800 


Ser Ser Gly Gly Gly Ser Val Ala Ser Gln Gly Phe Gly Phe Ser Ser 
                805                 810                 815     


Pro Asn Lys Thr Gly Gly Phe Gly Ala Ala Pro Val Phe Gly Ser Pro 
            820                 825                 830         


Pro Thr Phe Gly Gly Ser Pro Gly Phe Gly Gly Val Pro Ala Phe Gly 
        835                 840                 845             


Ser Ala Pro Ala Phe Thr Ser Pro Leu Gly Ser Thr Gly Gly Lys Val 
    850                 855                 860                 


Phe Gly Glu Gly Thr Ala Ala Ala Ser Ala Gly Gly Phe Gly Ser Leu 
865                 870                 875                 880 


Ala Met Ser Leu Ser Pro Thr Leu Lys Gly Arg Leu Leu Leu Met Arg 
                885                 890                 895     


Pro Lys Ala Gly Gly Gly Arg Glu Gln Ala Ala Pro Gly Arg Lys Ser 
            900                 905                 910         


Asn Glu Ser Arg Ser Leu Gly His Leu Cys Met Glu Arg Ala Leu Thr 
        915                 920                 925             


Ser Pro Leu Lys Val Trp Glu Gln Gln Gln His His Ile Leu Arg His 
    930                 935                 940                 


Ala Arg Glu Ser Glu Cys Pro His Phe Arg Ile Thr Val Pro Thr Asp 
945                 950                 955                 960 


Phe Trp Phe Trp Asp Pro Glu 
                965         


<210>  9697
<211>  114
<212>  PRT
<213>  Homo Sapiens

<400>  9697

Ala Met Met Leu Ser Asp Arg Leu Thr Phe Leu Gly Lys Tyr Arg Glu 
1               5                   10                  15      


Phe His Arg Met Tyr Gly Glu Lys Arg Phe Ala Asp Ala Ala Ser Leu 
            20                  25                  30          


Leu Leu Ser Leu Met Thr Ser Arg Ile Ala Pro Arg Ser Phe Trp Met 
        35                  40                  45              


Thr Leu Leu Thr Asp Ala Leu Pro Leu Leu Glu Gln Lys Gln Val Ile 
    50                  55                  60                  


Phe Ser Ala Glu Gln Thr Tyr Glu Leu Met Arg Cys Leu Glu Asp Leu 
65                  70                  75                  80  


Thr Ser Arg Arg Pro Val His Gly Glu Ser Asp Thr Glu Gln Leu Gln 
                85                  90                  95      


Tyr Gly Pro Leu Val Leu Leu Ser Phe Thr Ser Ile Ile Cys Trp Lys 
            100                 105                 110         


Leu Leu 
        


<210>  9698
<211>  191
<212>  PRT
<213>  Homo Sapiens

<400>  9698

Leu Asp Trp Val Arg Leu His Val Cys Glu Val Asp Ser Leu Ser Ala 
1               5                   10                  15      


Asp Val Leu Gly Ser Glu Asn Pro Ser Lys His Asp Ser Phe Trp Asn 
            20                  25                  30          


Leu Gly Arg Leu Asp Glu Ala Arg Gln Met Leu Ser Lys Glu Ala Asp 
        35                  40                  45              


Ala Ser Pro Ala Ser Ala Gly Ile Cys Arg Ile Met Gly Asp Leu Met 
    50                  55                  60                  


Arg Thr Met Pro Ile Leu Ser Pro Gly Asn Thr Gln Thr Leu Thr Glu 
65                  70                  75                  80  


Leu Glu Leu Lys Trp Gln His Trp His Glu Glu Cys Glu Arg Tyr Leu 
                85                  90                  95      


Gln Asp Ser Thr Phe Ala Thr Ser Pro His Leu Glu Ser Leu Leu Lys 
            100                 105                 110         


Ile Met Leu Gly Asp Glu Ala Ala Leu Leu Glu Gln Lys Glu Leu Leu 
        115                 120                 125             


Ser Asn Trp Tyr His Phe Leu Val Thr Arg Leu Leu Tyr Ser Asn Pro 
    130                 135                 140                 


Thr Val Lys Pro Ile Asp Leu His Tyr Tyr Ala Gln Ser Ser Leu Asp 
145                 150                 155                 160 


Leu Phe Leu Gly Gly Glu Ser Ser Pro Glu Pro Leu Asp Asn Ile Leu 
                165                 170                 175     


Leu Ala Ala Phe Glu Phe Asp Ile His Gln Val Ile Lys Glu Cys 
            180                 185                 190     


<210>  9699
<211>  19
<212>  PRT
<213>  Homo Sapiens

<400>  9699

Leu Leu Ala Ala Phe Glu Phe Asp Ile His Gln Val Ile Lys Glu Cys 
1               5                   10                  15      


Ser Phe Leu 
            


<210>  9700
<211>  18
<212>  PRT
<213>  Homo Sapiens

<400>  9700

Leu Thr Asp Ala Leu Pro Leu Leu Glu Gln Lys Gln Gln Asn Arg Leu 
1               5                   10                  15      


Met Ser 
        


<210>  9701
<211>  611
<212>  PRT
<213>  Homo Sapiens

<400>  9701

Met Glu Glu Leu Asp Gly Glu Pro Thr Val Thr Leu Ile Pro Gly Val 
1               5                   10                  15      


Asn Ser Lys Lys Asn Gln Met Tyr Phe Asp Trp Gly Pro Gly Glu Met 
            20                  25                  30          


Leu Val Cys Glu Thr Ser Phe Asn Lys Lys Glu Lys Ser Glu Met Val 
        35                  40                  45              


Pro Ser Cys Pro Phe Ile Tyr Ile Ile Arg Lys Asp Val Asp Val Tyr 
    50                  55                  60                  


Ser Gln Ile Leu Arg Lys Leu Phe Asn Glu Ser His Gly Ile Phe Leu 
65                  70                  75                  80  


Gly Leu Gln Arg Ile Asp Glu Glu Leu Thr Gly Lys Ser Arg Lys Ser 
                85                  90                  95      


Gln Leu Val Arg Val Ser Lys Asn Tyr Arg Ser Val Ile Arg Ala Cys 
            100                 105                 110         


Met Glu Glu Met His Gln Val Ala Ile Ala Ala Lys Asp Pro Ala Asn 
        115                 120                 125             


Gly Arg Gln Phe Ser Ser Gln Val Ser Ile Leu Ser Ala Met Glu Leu 
    130                 135                 140                 


Ile Trp Asn Leu Cys Glu Ile Leu Phe Ile Glu Val Ala Pro Ala Gly 
145                 150                 155                 160 


Pro Leu Leu Leu His Leu Leu Asp Trp Val Arg Leu His Val Cys Glu 
                165                 170                 175     


Val Asp Ser Leu Ser Ala Asp Val Leu Gly Ser Glu Asn Pro Ser Lys 
            180                 185                 190         


His Asp Ser Phe Trp Asn Leu Pro Gly Asn Thr Gln Thr Leu Thr Glu 
        195                 200                 205             


Leu Glu Leu Lys Trp Gln His Trp His Glu Glu Cys Glu Arg Tyr Leu 
    210                 215                 220                 


Gln Asp Ser Thr Phe Ala Thr Ser Pro His Leu Glu Ser Leu Leu Lys 
225                 230                 235                 240 


Ile Met Leu Gly Asp Glu Ala Ala Leu Leu Glu Gln Lys Glu Leu Leu 
                245                 250                 255     


Ser Asn Trp Tyr His Phe Leu Val Thr Arg Leu Leu Tyr Ser Asn Pro 
            260                 265                 270         


Thr Val Lys Pro Ile Asp Leu His Tyr Tyr Ala Gln Ser Ser Leu Asp 
        275                 280                 285             


Leu Phe Leu Gly Gly Glu Ser Ser Pro Glu Pro Leu Asp Asn Ile Leu 
    290                 295                 300                 


Leu Ala Ala Phe Glu Phe Asp Ile His Gln Val Ile Lys Glu Cys Ser 
305                 310                 315                 320 


Ile Ala Leu Ser Asn Trp Trp Phe Val Ala His Leu Thr Asp Leu Leu 
                325                 330                 335     


Asp His Cys Lys Leu Leu Gln Ser His Asn Leu Tyr Phe Gly Ser Asn 
            340                 345                 350         


Met Arg Glu Phe Leu Leu Leu Glu Tyr Ala Ser Gly Leu Phe Ala His 
        355                 360                 365             


Pro Ser Leu Trp Gln Leu Gly Val Asp Tyr Phe Asp Tyr Cys Pro Glu 
    370                 375                 380                 


Leu Gly Arg Val Ser Leu Glu Leu His Ile Glu Arg Ile Pro Leu Asn 
385                 390                 395                 400 


Thr Glu Gln Lys Ala Leu Lys Val Leu Arg Ile Cys Glu Gln Arg Gln 
                405                 410                 415     


Met Thr Glu Gln Val Arg Ser Ile Cys Lys Ile Leu Ala Met Lys Ala 
            420                 425                 430         


Val Arg Asn Asn Arg Leu Gly Ser Ala Leu Ser Trp Ser Ile Arg Ala 
        435                 440                 445             


Lys Asp Ala Ala Phe Ala Thr Leu Val Ser Asp Arg Phe Leu Arg Asp 
    450                 455                 460                 


Tyr Cys Glu Arg Gly Cys Phe Ser Asp Leu Asp Leu Ile Asp Asn Leu 
465                 470                 475                 480 


Gly Pro Ala Met Met Leu Ser Asp Arg Leu Thr Phe Leu Gly Lys Tyr 
                485                 490                 495     


Arg Glu Phe His Arg Met Tyr Gly Glu Lys Arg Phe Ala Asp Ala Ala 
            500                 505                 510         


Ser Leu Leu Leu Ser Leu Met Thr Ser Arg Ile Ala Pro Arg Ser Phe 
        515                 520                 525             


Trp Met Thr Leu Leu Thr Asp Ala Leu Pro Leu Leu Glu Gln Lys Gln 
    530                 535                 540                 


Val Ile Phe Ser Ala Glu Gln Thr Tyr Glu Leu Met Arg Cys Leu Glu 
545                 550                 555                 560 


Asp Leu Thr Ser Arg Arg Pro Val His Gly Glu Ser Asp Thr Glu Gln 
                565                 570                 575     


Leu Gln Asp Asp Asp Ile Glu Thr Thr Lys Val Glu Met Leu Arg Leu 
            580                 585                 590         


Ser Leu Ala Arg Asn Leu Ala Arg Ala Ile Ile Arg Glu Gly Ser Leu 
        595                 600                 605             


Glu Gly Ser 
    610     


<210>  9702
<211>  656
<212>  PRT
<213>  Homo Sapiens

<400>  9702

Met Glu Glu Leu Asp Gly Glu Pro Thr Val Thr Leu Ile Pro Gly Val 
1               5                   10                  15      


Asn Ser Lys Lys Asn Gln Met Tyr Phe Asp Trp Gly Pro Gly Glu Met 
            20                  25                  30          


Leu Val Cys Glu Thr Ser Phe Asn Lys Lys Glu Lys Ser Glu Met Val 
        35                  40                  45              


Pro Ser Cys Pro Phe Ile Tyr Ile Ile Arg Lys Asp Val Asp Val Tyr 
    50                  55                  60                  


Ser Gln Ile Leu Arg Lys Leu Phe Asn Glu Ser His Gly Ile Phe Leu 
65                  70                  75                  80  


Gly Leu Gln Arg Ile Asp Glu Glu Leu Thr Gly Lys Ser Arg Lys Ser 
                85                  90                  95      


Gln Leu Val Arg Val Ser Lys Asn Tyr Arg Ser Val Ile Arg Ala Cys 
            100                 105                 110         


Met Glu Glu Met His Gln Val Ala Ile Ala Ala Lys Asp Pro Ala Asn 
        115                 120                 125             


Gly Arg Gln Phe Ser Ser Gln Val Ser Ile Leu Ser Ala Met Glu Leu 
    130                 135                 140                 


Ile Trp Asn Leu Cys Glu Ile Leu Phe Ile Glu Val Ala Pro Ala Gly 
145                 150                 155                 160 


Pro Leu Leu Leu His Leu Leu Asp Trp Val Arg Leu His Val Cys Glu 
                165                 170                 175     


Val Asp Ser Leu Ser Ala Asp Val Leu Gly Ser Glu Asn Pro Ser Lys 
            180                 185                 190         


His Asp Ser Phe Trp Asn Leu Val Thr Ile Leu Val Leu Gln Gly Arg 
        195                 200                 205             


Leu Asp Glu Ala Arg Gln Met Leu Ser Lys Glu Ala Asp Ala Ser Pro 
    210                 215                 220                 


Ala Ser Ala Gly Ile Cys Arg Ile Met Gly Asp Leu Met Arg Thr Met 
225                 230                 235                 240 


Pro Ile Leu Ser Pro Gly Asn Thr Gln Thr Leu Thr Glu Leu Glu Leu 
                245                 250                 255     


Lys Trp Gln His Trp His Glu Glu Cys Glu Arg Tyr Leu Gln Asp Ser 
            260                 265                 270         


Thr Phe Ala Thr Ser Pro His Leu Glu Ser Leu Leu Lys Ile Met Leu 
        275                 280                 285             


Gly Asp Glu Ala Ala Leu Leu Glu Gln Lys Glu Leu Leu Ser Asn Trp 
    290                 295                 300                 


Tyr His Phe Leu Val Thr Arg Leu Leu Tyr Ser Asn Pro Thr Val Lys 
305                 310                 315                 320 


Pro Ile Asp Leu His Tyr Tyr Ala Gln Ser Ser Leu Asp Leu Phe Leu 
                325                 330                 335     


Gly Gly Glu Ser Ser Pro Glu Pro Leu Asp Asn Ile Leu Leu Ala Ala 
            340                 345                 350         


Phe Glu Phe Asp Ile His Gln Val Ile Lys Glu Cys Ser Ile Ala Leu 
        355                 360                 365             


Ser Asn Trp Trp Phe Val Ala His Leu Thr Asp Leu Leu Asp His Cys 
    370                 375                 380                 


Lys Leu Leu Gln Ser His Asn Leu Tyr Phe Gly Ser Asn Met Arg Glu 
385                 390                 395                 400 


Phe Leu Leu Leu Glu Tyr Ala Ser Gly Leu Phe Ala His Pro Ser Leu 
                405                 410                 415     


Trp Gln Leu Gly Val Asp Tyr Phe Asp Tyr Cys Pro Glu Leu Gly Arg 
            420                 425                 430         


Val Ser Leu Glu Leu His Ile Glu Arg Ile Pro Leu Asn Thr Glu Gln 
        435                 440                 445             


Lys Ala Leu Lys Val Leu Arg Ile Cys Glu Gln Arg Gln Met Thr Glu 
    450                 455                 460                 


Gln Val Arg Ser Ile Cys Lys Ile Leu Ala Met Lys Ala Val Arg Asn 
465                 470                 475                 480 


Asn Arg Leu Gly Ser Ala Leu Ser Trp Ser Ile Arg Ala Lys Asp Ala 
                485                 490                 495     


Ala Phe Ala Thr Leu Val Ser Asp Arg Phe Leu Arg Asp Tyr Cys Glu 
            500                 505                 510         


Arg Gly Cys Phe Ser Asp Leu Asp Leu Ile Asp Asn Leu Gly Pro Ala 
        515                 520                 525             


Met Met Leu Ser Asp Arg Leu Thr Phe Leu Gly Lys Tyr Arg Glu Phe 
    530                 535                 540                 


His Arg Met Tyr Gly Glu Lys Arg Phe Ala Asp Ala Ala Ser Leu Leu 
545                 550                 555                 560 


Leu Ser Leu Met Thr Ser Arg Ile Ala Pro Arg Ser Phe Trp Met Thr 
                565                 570                 575     


Leu Leu Thr Asp Ala Leu Pro Leu Leu Glu Gln Lys Gln Val Ile Phe 
            580                 585                 590         


Ser Ala Glu Gln Thr Tyr Glu Leu Met Arg Cys Leu Glu Asp Leu Thr 
        595                 600                 605             


Ser Arg Arg Pro Val His Gly Glu Ser Asp Thr Glu Gln Leu Gln Asp 
    610                 615                 620                 


Asp Asp Ile Glu Thr Thr Lys Val Glu Met Leu Arg Leu Ser Leu Ala 
625                 630                 635                 640 


Arg Asn Leu Ala Arg Ala Ile Ile Arg Glu Gly Ser Leu Glu Gly Ser 
                645                 650                 655     


<210>  9703
<211>  169
<212>  PRT
<213>  Homo Sapiens

<400>  9703

Met Glu Glu Leu Asp Gly Glu Pro Thr Val Thr Leu Ile Pro Gly Val 
1               5                   10                  15      


Asn Ser Lys Lys Asn Gln Met Tyr Phe Asp Trp Gly Pro Gly Glu Met 
            20                  25                  30          


Leu Val Cys Glu Thr Ser Phe Asn Lys Lys Glu Lys Ser Glu Met Val 
        35                  40                  45              


Pro Ser Cys Pro Phe Ile Tyr Ile Ile Arg Lys Asp Val Asp Val Tyr 
    50                  55                  60                  


Ser Gln Ile Leu Arg Lys Leu Phe Asn Glu Ser His Gly Ile Phe Leu 
65                  70                  75                  80  


Gly Leu Gln Arg Ile Asp Glu Glu Leu Thr Gly Lys Ser Arg Lys Ser 
                85                  90                  95      


Gln Leu Val Arg Val Ser Lys Asn Tyr Arg Ser Val Ile Arg Ala Cys 
            100                 105                 110         


Met Glu Glu Met His Gln Val Ala Ile Ala Ala Lys Asp Pro Ala Asn 
        115                 120                 125             


Gly Arg Gln Phe Ser Ser Gln Val Ser Ile Leu Ser Ala Met Glu Leu 
    130                 135                 140                 


Ile Trp Asn Leu Cys Glu Ile Leu Phe Ile Glu Val Ala Pro Gly Asp 
145                 150                 155                 160 


His Leu Gly Ala Ala Gly Pro Ala Gly 
                165                 


<210>  9704
<211>  544
<212>  PRT
<213>  Homo Sapiens

<400>  9704

Met Glu Glu Met His Gln Val Ala Ile Ala Ala Lys Asp Pro Ala Asn 
1               5                   10                  15      


Gly Arg Gln Phe Ser Ser Gln Val Ser Ile Leu Ser Ala Met Glu Leu 
            20                  25                  30          


Ile Trp Asn Leu Cys Glu Ile Leu Phe Ile Glu Val Ala Pro Ala Gly 
        35                  40                  45              


Pro Leu Leu Leu His Leu Leu Asp Trp Val Arg Leu His Val Cys Glu 
    50                  55                  60                  


Val Asp Ser Leu Ser Ala Asp Val Leu Gly Ser Glu Asn Pro Ser Lys 
65                  70                  75                  80  


His Asp Ser Phe Trp Asn Leu Val Thr Ile Leu Val Leu Gln Gly Arg 
                85                  90                  95      


Leu Asp Glu Ala Arg Gln Met Leu Ser Lys Glu Ala Asp Ala Ser Pro 
            100                 105                 110         


Ala Ser Ala Gly Ile Cys Arg Ile Met Gly Asp Leu Met Arg Thr Met 
        115                 120                 125             


Pro Ile Leu Ser Pro Gly Asn Thr Gln Thr Leu Thr Glu Leu Glu Leu 
    130                 135                 140                 


Lys Trp Gln His Trp His Glu Glu Cys Glu Arg Tyr Leu Gln Asp Ser 
145                 150                 155                 160 


Thr Phe Ala Thr Ser Pro His Leu Glu Ser Leu Leu Lys Ile Met Leu 
                165                 170                 175     


Gly Asp Glu Ala Ala Leu Leu Glu Gln Lys Glu Leu Leu Ser Asn Trp 
            180                 185                 190         


Tyr His Phe Leu Val Thr Arg Leu Leu Tyr Ser Asn Pro Thr Val Lys 
        195                 200                 205             


Pro Ile Asp Leu His Tyr Tyr Ala Gln Ser Ser Leu Asp Leu Phe Leu 
    210                 215                 220                 


Gly Gly Glu Ser Ser Pro Glu Pro Leu Asp Asn Ile Leu Leu Ala Ala 
225                 230                 235                 240 


Phe Glu Phe Asp Ile His Gln Val Ile Lys Glu Cys Ser Ile Ala Leu 
                245                 250                 255     


Ser Asn Trp Trp Phe Val Ala His Leu Thr Asp Leu Leu Asp His Cys 
            260                 265                 270         


Lys Leu Leu Gln Ser His Asn Leu Tyr Phe Gly Ser Asn Met Arg Glu 
        275                 280                 285             


Phe Leu Leu Leu Glu Tyr Ala Ser Gly Leu Phe Ala His Pro Ser Leu 
    290                 295                 300                 


Trp Gln Leu Gly Val Asp Tyr Phe Asp Tyr Cys Pro Glu Leu Gly Arg 
305                 310                 315                 320 


Val Ser Leu Glu Leu His Ile Glu Arg Ile Pro Leu Asn Thr Glu Gln 
                325                 330                 335     


Lys Ala Leu Lys Val Leu Arg Ile Cys Glu Gln Arg Gln Met Thr Glu 
            340                 345                 350         


Gln Val Arg Ser Ile Cys Lys Ile Leu Ala Met Lys Ala Val Arg Asn 
        355                 360                 365             


Asn Arg Leu Gly Ser Ala Leu Ser Trp Ser Ile Arg Ala Lys Asp Ala 
    370                 375                 380                 


Ala Phe Ala Thr Leu Val Ser Asp Arg Phe Leu Arg Asp Tyr Cys Glu 
385                 390                 395                 400 


Arg Gly Cys Phe Ser Asp Leu Asp Leu Ile Asp Asn Leu Gly Pro Ala 
                405                 410                 415     


Met Met Leu Ser Asp Arg Leu Thr Phe Leu Gly Lys Tyr Arg Glu Phe 
            420                 425                 430         


His Arg Met Tyr Gly Glu Lys Arg Phe Ala Asp Ala Ala Ser Leu Leu 
        435                 440                 445             


Leu Ser Leu Met Thr Ser Arg Ile Ala Pro Arg Ser Phe Trp Met Thr 
    450                 455                 460                 


Leu Leu Thr Asp Ala Leu Pro Leu Leu Glu Gln Lys Gln Val Ile Phe 
465                 470                 475                 480 


Ser Ala Glu Gln Thr Tyr Glu Leu Met Arg Cys Leu Glu Asp Leu Thr 
                485                 490                 495     


Ser Arg Arg Pro Val His Gly Glu Ser Asp Thr Glu Gln Leu Gln Asp 
            500                 505                 510         


Asp Asp Ile Glu Thr Thr Lys Val Glu Met Leu Arg Leu Ser Leu Ala 
        515                 520                 525             


Arg Asn Leu Ala Arg Ala Ile Ile Arg Glu Gly Ser Leu Glu Gly Ser 
    530                 535                 540                 


<210>  9705
<211>  259
<212>  PRT
<213>  Homo Sapiens

<400>  9705

Met Arg Glu Phe Leu Leu Leu Glu Tyr Ala Ser Gly Leu Phe Ala His 
1               5                   10                  15      


Pro Ser Leu Trp Gln Leu Gly Val Asp Tyr Phe Asp Tyr Cys Pro Glu 
            20                  25                  30          


Leu Gly Arg Val Ser Leu Glu Leu His Ile Glu Arg Ile Pro Leu Asn 
        35                  40                  45              


Thr Glu Gln Lys Ala Leu Lys Val Leu Arg Ile Cys Glu Gln Arg Gln 
    50                  55                  60                  


Met Thr Glu Gln Val Arg Ser Ile Cys Lys Ile Leu Ala Met Lys Ala 
65                  70                  75                  80  


Val Arg Asn Asn Arg Leu Gly Ser Ala Leu Ser Trp Ser Ile Arg Ala 
                85                  90                  95      


Lys Asp Ala Ala Phe Ala Thr Leu Val Ser Asp Arg Phe Leu Arg Asp 
            100                 105                 110         


Tyr Cys Glu Arg Gly Cys Phe Ser Asp Leu Asp Leu Ile Asp Asn Leu 
        115                 120                 125             


Gly Pro Ala Met Met Leu Ser Asp Arg Leu Thr Phe Leu Gly Lys Tyr 
    130                 135                 140                 


Arg Glu Phe His Arg Met Tyr Gly Glu Lys Arg Phe Ala Asp Ala Ala 
145                 150                 155                 160 


Ser Leu Leu Leu Ser Leu Met Thr Ser Arg Ile Ala Pro Arg Ser Phe 
                165                 170                 175     


Trp Met Thr Leu Leu Thr Asp Ala Leu Pro Leu Leu Glu Gln Lys Gln 
            180                 185                 190         


Val Ile Phe Ser Ala Glu Gln Thr Tyr Glu Leu Met Arg Cys Leu Glu 
        195                 200                 205             


Asp Leu Thr Ser Arg Arg Pro Val His Gly Glu Ser Asp Thr Glu Gln 
    210                 215                 220                 


Leu Gln Asp Asp Asp Ile Glu Thr Thr Lys Val Glu Met Leu Arg Leu 
225                 230                 235                 240 


Ser Leu Ala Arg Asn Leu Ala Arg Ala Ile Ile Arg Glu Gly Ser Leu 
                245                 250                 255     


Glu Gly Ser 
            


<210>  9706
<211>  120
<212>  PRT
<213>  Homo Sapiens

<400>  9706

Met Tyr Phe Asp Trp Gly Pro Gly Glu Met Leu Val Cys Glu Thr Ser 
1               5                   10                  15      


Phe Asn Lys Lys Glu Lys Ser Glu Met Val Pro Ser Cys Pro Phe Ile 
            20                  25                  30          


Tyr Ile Ile Arg Lys Asp Val Asp Val Tyr Ser Gln Ile Leu Arg Lys 
        35                  40                  45              


Leu Phe Asn Glu Ser His Gly Ile Phe Leu Gly Leu Gln Arg Ile Asp 
    50                  55                  60                  


Glu Glu Leu Thr Gly Lys Ser Arg Lys Ser Gln Leu Val Arg Val Ser 
65                  70                  75                  80  


Lys Asn Tyr Arg Ser Val Ile Arg Ala Cys Met Glu Glu Met His Gln 
                85                  90                  95      


Val Ala Ile Ala Ala Lys Asp Pro Ala Asn Gly Arg Gln Phe Ser Ser 
            100                 105                 110         


Gln Val Ser Ile Leu Ser Ala Met 
        115                 120 


<210>  9707
<211>  272
<212>  PRT
<213>  Homo Sapiens

<400>  9707

Val Thr Ile Leu Val Leu Gln Gly Arg Leu Asp Glu Ala Arg Gln Met 
1               5                   10                  15      


Leu Ser Lys Glu Ala Asp Ala Ser Pro Ala Ser Ala Gly Ile Cys Arg 
            20                  25                  30          


Ile Met Gly Asp Leu Met Arg Thr Met Pro Ile Leu Ser Pro Gly Asn 
        35                  40                  45              


Thr Gln Thr Leu Thr Glu Leu Glu Leu Lys Trp Gln His Trp His Glu 
    50                  55                  60                  


Glu Cys Glu Arg Tyr Leu Gln Asp Ser Thr Phe Ala Thr Ser Pro His 
65                  70                  75                  80  


Leu Glu Ser Leu Leu Lys Ile Met Leu Gly Asp Glu Ala Ala Leu Leu 
                85                  90                  95      


Glu Gln Lys Glu Leu Leu Ser Asn Trp Tyr His Phe Leu Val Thr Arg 
            100                 105                 110         


Leu Leu Tyr Ser Asn Pro Thr Val Lys Pro Ile Asp Leu His Tyr Tyr 
        115                 120                 125             


Ala Gln Ser Ser Leu Asp Leu Phe Leu Gly Gly Glu Ser Ser Pro Glu 
    130                 135                 140                 


Pro Leu Asp Asn Ile Leu Leu Ala Ala Phe Glu Phe Asp Ile His Gln 
145                 150                 155                 160 


Val Ile Lys Glu Cys Ser Phe Gly Ser Asn Met Arg Glu Phe Leu Leu 
                165                 170                 175     


Leu Glu Tyr Ala Ser Gly Leu Phe Ala His Pro Ser Leu Trp Gln Leu 
            180                 185                 190         


Gly Val Asp Tyr Phe Asp Tyr Cys Pro Glu Leu Gly Arg Val Ser Leu 
        195                 200                 205             


Glu Leu His Ile Glu Arg Ile Pro Leu Asn Thr Glu Gln Lys Ala Leu 
    210                 215                 220                 


Lys Val Leu Arg Ile Cys Glu Gln Arg Gln Met Thr Glu Gln Val Arg 
225                 230                 235                 240 


Ser Ile Cys Lys Ile Leu Ala Met Lys Ala Val Arg Asn Asn Arg Leu 
                245                 250                 255     


Gly Ser Ala Leu Ser Trp Ser Ile Arg Ala Lys Asp Ala Ala Phe Ala 
            260                 265                 270         


<210>  9708
<211>  46
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9708

Xaa Glu Lys Arg Phe Ala Asp Ala Ala Ser Leu Leu Leu Ser Leu Met 
1               5                   10                  15      


Thr Ser Arg Ile Ala Pro Arg Ser Phe Trp Met Thr Leu Leu Thr Asp 
            20                  25                  30          


Ala Leu Pro Leu Leu Glu Gln Lys Gln Asn Arg Leu Met Ser 
        35                  40                  45      


<210>  9709
<211>  302
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9709

Xaa His Glu Glu Cys Glu Arg Tyr Leu Gln Asp Ser Thr Phe Ala Thr 
1               5                   10                  15      


Ser Pro His Leu Glu Ser Leu Leu Lys Ser Ser Leu Asp Leu Phe Leu 
            20                  25                  30          


Gly Gly Glu Ser Ser Pro Glu Pro Leu Asp Asn Ile Leu Leu Ala Ala 
        35                  40                  45              


Phe Glu Phe Asp Ile His Gln Val Ile Lys Glu Cys Ser Ile Ala Leu 
    50                  55                  60                  


Ser Asn Trp Trp Phe Val Ala His Leu Thr Asp Leu Leu Asp His Cys 
65                  70                  75                  80  


Lys Leu Leu Gln Ser His Asn Leu Tyr Phe Gly Ser Asn Met Arg Glu 
                85                  90                  95      


Phe Leu Leu Leu Glu Tyr Ala Ser Gly Leu Phe Ala His Pro Ser Leu 
            100                 105                 110         


Trp Gln Leu Gly Val Asp Tyr Phe Asp Tyr Cys Pro Glu Leu Gly Arg 
        115                 120                 125             


Val Ser Leu Glu Leu His Ile Glu Arg Ile Pro Leu Asn Thr Glu Gln 
    130                 135                 140                 


Lys Ala Leu Lys Val Leu Arg Ile Cys Glu Gln Arg Gln Met Thr Glu 
145                 150                 155                 160 


Gln Val Arg Ser Ile Cys Lys Ile Leu Ala Met Lys Ala Val Arg Asn 
                165                 170                 175     


Asn Arg Leu Gly Ser Ala Leu Ser Trp Ser Ile Arg Ala Lys Asp Ala 
            180                 185                 190         


Ala Phe Ala Thr Leu Val Ser Asp Arg Phe Leu Arg Asp Tyr Cys Glu 
        195                 200                 205             


Arg Gly Cys Phe Ser Asp Leu Asp Leu Ile Asp Asn Leu Gly Pro Ala 
    210                 215                 220                 


Met Met Leu Ser Asp Arg Leu Thr Phe Leu Gly Lys Tyr Arg Glu Phe 
225                 230                 235                 240 


His Arg Met Tyr Gly Glu Lys Arg Phe Ala Asp Ala Ala Ser Leu Leu 
                245                 250                 255     


Leu Ser Leu Met Thr Ser Arg Ile Ala Pro Arg Ser Phe Trp Met Thr 
            260                 265                 270         


Leu Leu Thr Asp Ala Leu Pro Leu Leu Glu Gln Lys Gln Val Ile Phe 
        275                 280                 285             


Ser Ala Glu Gln Thr Tyr Glu Leu Met Arg Cys Leu Glu Asp 
    290                 295                 300         


<210>  9710
<211>  100
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9710

Xaa Leu Phe Ile Glu Val Ala Pro Ala Gly Pro Leu Leu Leu His Leu 
1               5                   10                  15      


Leu Asp Trp Val Arg Leu His Val Cys Glu Val Asp Ser Leu Ser Ala 
            20                  25                  30          


Asp Val Leu Gly Ser Glu Asn Pro Ser Lys His Asp Ser Phe Trp Asn 
        35                  40                  45              


Leu Ile Met Leu Gly Asp Glu Ala Ala Leu Leu Glu Gln Lys Glu Leu 
    50                  55                  60                  


Leu Ser Asn Trp Tyr His Phe Leu Val Thr Arg Leu Leu Tyr Ser Asn 
65                  70                  75                  80  


Pro Thr Val Lys Pro Ile Asp Leu His Tyr Tyr Ala Gln Pro Gly Pro 
                85                  90                  95      


Val Ser Gly Arg 
            100 


<210>  9711
<211>  98
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9711

Xaa Ser Leu Met Thr Ser Arg Ile Ala Pro Arg Ser Phe Trp Met Thr 
1               5                   10                  15      


Leu Leu Thr Asp Ala Leu Pro Leu Leu Glu Gln Lys Gln Val Lys Val 
            20                  25                  30          


Ile Phe Ser Ala Glu Gln Thr Tyr Glu Leu Met Arg Cys Leu Glu Asp 
        35                  40                  45              


Leu Thr Ser Arg Arg Pro Val His Gly Glu Ser Asp Thr Glu Gln Leu 
    50                  55                  60                  


Gln Asp Asp Asp Ile Glu Thr Thr Lys Val Glu Met Leu Arg Leu Ser 
65                  70                  75                  80  


Leu Ala Arg Asn Leu Ala Arg Ala Ile Ile Arg Glu Gly Ser Leu Glu 
                85                  90                  95      


Gly Ser 
        


<210>  9712
<211>  89
<212>  PRT
<213>  Homo Sapiens

<400>  9712

Met Pro Val Asn Ser Ser Gly Pro Asp Trp Val Thr Val Ile Pro Arg 
1               5                   10                  15      


Arg Ile Lys Glu Thr Asn Ser Leu Glu Leu Ser Gln Gly Ser Gly Thr 
            20                  25                  30          


Phe Pro Ser Gly Tyr Tyr Tyr Lys Asp Gln Trp Arg Pro Arg Lys Phe 
        35                  40                  45              


Lys Met Arg Gln Phe Asn Asp Pro Thr Thr Leu Gln Ser Ala Tyr Lys 
    50                  55                  60                  


Glu Lys Trp Cys Ile Tyr Leu Val Thr Gln Gln Ser Gly Asn Gly Leu 
65                  70                  75                  80  


Asn Thr Leu Leu His Leu Phe Gln Ile 
                85                  


<210>  9713
<211>  53
<212>  PRT
<213>  Homo Sapiens

<400>  9713

Met Trp Thr Asn Phe Phe Lys Leu Arg Leu Phe Cys Cys Leu Leu Ala 
1               5                   10                  15      


Val Leu Met Val Val Val Leu Val Ile Asn Val Thr Gln Val Glu Tyr 
            20                  25                  30          


Leu Asp His Glu Thr Val Ser Ala Thr Phe Ile Asp Ser Ser Gly Gln 
        35                  40                  45              


Phe Val Ser Ser Gln 
    50              


<210>  9714
<211>  559
<212>  PRT
<213>  Homo Sapiens

<400>  9714

Met Trp Thr Asn Phe Phe Lys Leu Arg Leu Phe Cys Cys Leu Leu Ala 
1               5                   10                  15      


Val Leu Met Val Val Val Leu Val Ile Asn Val Thr Gln Val Glu Tyr 
            20                  25                  30          


Leu Asp His Glu Thr Val Ser Ala Thr Phe Ile Asp Ser Ser Gly Gln 
        35                  40                  45              


Phe Val Ser Ser Gln Val Thr Gly Ile Ser Arg Asn Pro Tyr Cys Gly 
    50                  55                  60                  


Tyr Asp Gln Gln Thr Leu Ser Ser Gln Glu Arg Met Glu Glu Asp Ser 
65                  70                  75                  80  


Leu Leu Ala Ala Leu His Arg Gln Val Pro Asp Val Gly Pro Val Pro 
                85                  90                  95      


Phe Val Lys Ser Thr Asp Pro Ser Ser Ser Tyr Phe Val Ile Leu Asn 
            100                 105                 110         


Ser Ala Ala Phe Phe Lys Val Gly Ser Gln Leu Glu Val Leu Val His 
        115                 120                 125             


Val Gln Asp Phe Gln Arg Lys Pro Lys Lys Tyr Gly Gly Asp Tyr Leu 
    130                 135                 140                 


Gln Ala Arg Ile His Ser Leu Lys Leu Gln Ala Gly Ala Val Gly Arg 
145                 150                 155                 160 


Val Val Asp Tyr Gln Asn Gly Phe Tyr Lys Val Phe Phe Thr Leu Leu 
                165                 170                 175     


Trp Pro Gly Lys Val Lys Val Ser Val Ser Leu Val His Pro Ser Glu 
            180                 185                 190         


Gly Ile Arg Val Leu Gln Arg Leu Gln Glu Asp Lys Pro Asp Arg Val 
        195                 200                 205             


Tyr Phe Lys Ser Leu Phe Arg Ser Gly Arg Ile Ser Glu Thr Thr Glu 
    210                 215                 220                 


Cys Asn Val Cys Leu Pro Gly Asn Leu Pro Leu Cys Asn Phe Thr Asp 
225                 230                 235                 240 


Leu Tyr Thr Gly Glu Pro Trp Phe Cys Phe Lys Pro Lys Lys Leu Pro 
                245                 250                 255     


Cys Ser Ser Arg Ile Thr His Phe Lys Gly Gly Tyr Leu Lys Gly Leu 
            260                 265                 270         


Leu Thr Ala Ala Glu Ser Ala Phe Phe Gln Ser Gly Val Asn Ile Lys 
        275                 280                 285             


Met Pro Val Asn Ser Ser Gly Pro Asp Trp Val Thr Val Ile Pro Arg 
    290                 295                 300                 


Arg Ile Lys Glu Thr Asn Ser Leu Glu Leu Ser Gln Gly Ser Gly Thr 
305                 310                 315                 320 


Phe Pro Ser Gly Tyr Tyr Tyr Lys Asp Gln Trp Arg Pro Arg Lys Phe 
                325                 330                 335     


Lys Met Arg Gln Phe Asn Asp Pro Asp Asn Ile Thr Glu Cys Leu Gln 
            340                 345                 350         


Arg Lys Val Val His Leu Phe Gly Asp Ser Thr Ile Arg Gln Trp Phe 
        355                 360                 365             


Glu Tyr Leu Thr Thr Phe Val Pro Asp Leu Val Glu Phe Asn Leu Gly 
    370                 375                 380                 


Ser Pro Lys Asn Val Gly Pro Phe Leu Ala Val Asp Gln Lys His Asn 
385                 390                 395                 400 


Ile Leu Leu Lys Tyr Arg Cys His Gly Pro Pro Ile Arg Phe Thr Thr 
                405                 410                 415     


Val Phe Ser Asn Glu Leu His Tyr Val Ala Asn Glu Leu Asn Gly Ile 
            420                 425                 430         


Val Gly Gly Lys Asn Thr Val Val Ala Ile Ala Val Trp Ser His Phe 
        435                 440                 445             


Ser Thr Phe Pro Leu Glu Val Tyr Ile Arg Arg Leu Arg Asn Ile Arg 
    450                 455                 460                 


Arg Ala Val Val Arg Leu Leu Asp Arg Ser Pro Lys Thr Val Val Val 
465                 470                 475                 480 


Ile Arg Thr Ala Asn Ala Gln Glu Leu Gly Pro Glu Val Ser Leu Phe 
                485                 490                 495     


Asn Ser Asp Trp Tyr Asn Phe Gln Leu Asp Thr Ile Leu Arg Arg Met 
            500                 505                 510         


Phe Ser Gly Val Gly Val Tyr Leu Val Asp Ala Trp Glu Met Thr Leu 
        515                 520                 525             


Ala His Tyr Leu Pro His Lys Leu His Pro Asp Glu Val Ile Val Lys 
    530                 535                 540                 


Asn Gln Leu Asp Met Phe Leu Ser Phe Val Cys Pro Leu Glu Thr 
545                 550                 555                 


<210>  9715
<211>  559
<212>  PRT
<213>  Homo Sapiens

<400>  9715

Met Trp Thr Asn Phe Phe Lys Leu Arg Leu Phe Cys Cys Leu Leu Ala 
1               5                   10                  15      


Val Leu Met Val Val Val Leu Val Ile Asn Val Thr Gln Val Glu Tyr 
            20                  25                  30          


Leu Asp His Glu Thr Val Ser Ala Thr Phe Ile Asp Ser Ser Gly Gln 
        35                  40                  45              


Phe Val Ser Ser Gln Val Thr Gly Ile Ser Arg Asn Pro Tyr Cys Gly 
    50                  55                  60                  


Tyr Asp Gln Gln Thr Leu Ser Ser Gln Glu Arg Met Glu Glu Asp Ser 
65                  70                  75                  80  


Leu Leu Ala Ala Leu His Arg Gln Val Pro Asp Val Gly Pro Val Pro 
                85                  90                  95      


Phe Val Lys Ser Thr Asp Pro Ser Ser Ser Tyr Phe Val Ile Leu Asn 
            100                 105                 110         


Ser Ala Ala Phe Phe Lys Val Gly Ser Gln Leu Glu Val Leu Val His 
        115                 120                 125             


Val Gln Asp Phe Gln Arg Lys Pro Lys Lys Tyr Gly Gly Asp Tyr Leu 
    130                 135                 140                 


Gln Ala Arg Ile His Ser Leu Lys Leu Gln Ala Gly Ala Val Gly Arg 
145                 150                 155                 160 


Val Val Asp Tyr Gln Asn Gly Phe Tyr Lys Val Phe Phe Thr Leu Leu 
                165                 170                 175     


Trp Pro Gly Lys Val Lys Val Ser Val Ser Leu Val His Pro Ser Glu 
            180                 185                 190         


Gly Ile Arg Val Leu Gln Arg Leu Gln Glu Asp Lys Pro Asp Arg Val 
        195                 200                 205             


Tyr Phe Lys Ser Leu Phe Arg Ser Gly Arg Ile Ser Glu Thr Thr Glu 
    210                 215                 220                 


Cys Asn Val Cys Leu Pro Gly Asn Leu Pro Leu Cys Asn Phe Thr Asp 
225                 230                 235                 240 


Leu Tyr Thr Gly Glu Pro Trp Phe Cys Phe Lys Pro Lys Lys Leu Pro 
                245                 250                 255     


Cys Ser Ser Arg Ile Thr His Phe Lys Gly Gly Tyr Leu Lys Gly Leu 
            260                 265                 270         


Leu Thr Ala Ala Glu Ser Ala Phe Phe Gln Ser Gly Val Asn Ile Lys 
        275                 280                 285             


Met Pro Val Asn Ser Ser Gly Pro Asp Trp Val Thr Val Ile Pro Arg 
    290                 295                 300                 


Arg Ile Lys Glu Thr Asn Ser Leu Glu Leu Ser Gln Gly Ser Gly Thr 
305                 310                 315                 320 


Phe Pro Ser Gly Tyr Tyr Tyr Lys Asp Gln Trp Arg Pro Arg Lys Phe 
                325                 330                 335     


Lys Met Arg Gln Phe Asn Asp Pro Asp Asn Ile Thr Glu Cys Leu Gln 
            340                 345                 350         


Arg Lys Val Val His Leu Phe Gly Asp Ser Thr Ile Arg Gln Trp Phe 
        355                 360                 365             


Glu Tyr Leu Thr Thr Phe Val Pro Asp Leu Val Glu Phe Asn Leu Gly 
    370                 375                 380                 


Ser Pro Lys Asn Val Gly Pro Phe Leu Ala Val Asp Gln Lys His Asn 
385                 390                 395                 400 


Ile Leu Leu Lys Tyr Arg Cys His Gly Pro Pro Ile Arg Phe Thr Thr 
                405                 410                 415     


Val Phe Ser Asn Glu Leu His Tyr Val Ala Asn Glu Leu Asn Gly Ile 
            420                 425                 430         


Val Gly Gly Lys Asn Thr Val Val Ala Ile Ala Val Trp Ser His Phe 
        435                 440                 445             


Ser Thr Phe Pro Leu Glu Val Tyr Ile Arg Arg Leu Arg Asn Ile Arg 
    450                 455                 460                 


Arg Ala Val Val Arg Leu Leu Asp Arg Ser Pro Lys Thr Val Val Val 
465                 470                 475                 480 


Ile Arg Thr Ala Asn Ala Gln Glu Leu Gly Pro Glu Val Ser Leu Phe 
                485                 490                 495     


Asn Ser Asp Trp Tyr Asn Phe Gln Leu Asp Thr Ile Leu Arg Arg Met 
            500                 505                 510         


Phe Ser Gly Val Gly Val Tyr Leu Val Asp Ala Trp Glu Met Thr Leu 
        515                 520                 525             


Ala His Tyr Leu Pro His Lys Leu His Pro Asp Glu Val Ile Val Lys 
    530                 535                 540                 


Asn Gln Leu Asp Met Phe Leu Ser Phe Val Cys Pro Leu Glu Thr 
545                 550                 555                 


<210>  9716
<211>  559
<212>  PRT
<213>  Homo Sapiens

<400>  9716

Met Trp Thr Asn Phe Phe Lys Leu Arg Leu Phe Cys Cys Leu Leu Ala 
1               5                   10                  15      


Val Leu Met Val Val Val Leu Val Ile Asn Val Thr Gln Val Glu Tyr 
            20                  25                  30          


Leu Asp His Glu Thr Val Ser Ala Thr Phe Ile Asp Ser Ser Gly Gln 
        35                  40                  45              


Phe Val Ser Ser Gln Val Thr Gly Ile Ser Arg Asn Pro Tyr Cys Gly 
    50                  55                  60                  


Tyr Asp Gln Gln Thr Leu Ser Ser Gln Glu Arg Met Glu Glu Asp Ser 
65                  70                  75                  80  


Leu Leu Ala Ala Leu His Arg Gln Val Pro Asp Val Gly Pro Val Pro 
                85                  90                  95      


Phe Val Lys Ser Thr Asp Pro Ser Ser Ser Tyr Phe Val Ile Leu Asn 
            100                 105                 110         


Ser Ala Ala Phe Phe Lys Val Gly Ser Gln Leu Glu Val Leu Val His 
        115                 120                 125             


Val Gln Asp Phe Gln Arg Lys Pro Lys Lys Tyr Gly Gly Asp Tyr Leu 
    130                 135                 140                 


Gln Ala Arg Ile His Ser Leu Lys Leu Gln Ala Gly Ala Val Gly Arg 
145                 150                 155                 160 


Val Val Asp Tyr Gln Asn Gly Phe Tyr Lys Val Phe Phe Thr Leu Leu 
                165                 170                 175     


Trp Pro Gly Lys Val Lys Val Ser Val Ser Leu Val His Pro Ser Glu 
            180                 185                 190         


Gly Ile Arg Val Leu Gln Arg Leu Gln Glu Asp Lys Pro Asp Arg Val 
        195                 200                 205             


Tyr Phe Lys Ser Leu Phe Arg Ser Gly Arg Ile Ser Glu Thr Thr Glu 
    210                 215                 220                 


Cys Asn Val Cys Leu Pro Gly Asn Leu Pro Leu Cys Asn Phe Thr Asp 
225                 230                 235                 240 


Leu Tyr Thr Gly Glu Pro Trp Phe Cys Phe Lys Pro Lys Lys Leu Pro 
                245                 250                 255     


Cys Ser Ser Arg Ile Thr His Phe Lys Gly Gly Tyr Leu Lys Gly Leu 
            260                 265                 270         


Leu Thr Ala Ala Glu Ser Ala Phe Phe Gln Ser Gly Val Asn Ile Lys 
        275                 280                 285             


Met Pro Val Asn Ser Ser Gly Pro Asp Trp Val Thr Val Ile Pro Arg 
    290                 295                 300                 


Arg Ile Lys Glu Thr Asn Ser Leu Glu Leu Ser Gln Gly Ser Gly Thr 
305                 310                 315                 320 


Phe Pro Ser Gly Tyr Tyr Tyr Lys Asp Gln Trp Arg Pro Arg Lys Phe 
                325                 330                 335     


Lys Met Arg Gln Phe Asn Asp Pro Asp Asn Ile Thr Glu Cys Leu Gln 
            340                 345                 350         


Arg Lys Val Val His Leu Phe Gly Asp Ser Thr Ile Arg Gln Trp Phe 
        355                 360                 365             


Glu Tyr Leu Thr Thr Phe Val Pro Asp Leu Val Glu Phe Asn Leu Gly 
    370                 375                 380                 


Ser Pro Lys Asn Val Gly Pro Phe Leu Ala Val Asp Gln Lys His Asn 
385                 390                 395                 400 


Ile Leu Leu Lys Tyr Arg Cys His Gly Pro Pro Ile Arg Phe Thr Thr 
                405                 410                 415     


Val Phe Ser Asn Glu Leu His Tyr Val Ala Asn Glu Leu Asn Gly Ile 
            420                 425                 430         


Val Gly Gly Lys Asn Thr Val Val Ala Ile Ala Val Trp Ser His Phe 
        435                 440                 445             


Ser Thr Phe Pro Leu Glu Val Tyr Ile Arg Arg Leu Arg Asn Ile Arg 
    450                 455                 460                 


Arg Ala Val Val Arg Leu Leu Asp Arg Ser Pro Lys Thr Val Val Val 
465                 470                 475                 480 


Ile Arg Thr Ala Asn Ala Gln Glu Leu Gly Pro Glu Val Ser Leu Phe 
                485                 490                 495     


Asn Ser Asp Trp Tyr Asn Phe Gln Leu Asp Thr Ile Leu Arg Arg Met 
            500                 505                 510         


Phe Ser Gly Val Gly Val Tyr Leu Val Asp Ala Trp Glu Met Thr Leu 
        515                 520                 525             


Ala His Tyr Leu Pro His Lys Leu His Pro Asp Glu Val Ile Val Lys 
    530                 535                 540                 


Asn Gln Leu Asp Met Phe Leu Ser Phe Val Cys Pro Leu Glu Thr 
545                 550                 555                 


<210>  9717
<211>  260
<212>  PRT
<213>  Homo Sapiens

<400>  9717

Met Glu Lys Phe Asn Thr Ile Ser Val Ser Lys Cys Asn Lys Glu Thr 
1               5                   10                  15      


Val Ala Met Lys Glu Lys Cys Lys Phe Gly Met Thr Ser Thr Ile Pro 
            20                  25                  30          


Ser Gly His Val Trp Arg Asn Thr Trp Asn Pro Val Ser Cys Ser Leu 
        35                  40                  45              


Ala Thr Val Lys Met Lys Glu Cys Leu Arg Gly Lys Leu Ile Tyr Leu 
    50                  55                  60                  


Met Gly Asp Ser Thr Ile Arg Gln Trp Met Glu Tyr Phe Lys Ala Ser 
65                  70                  75                  80  


Ile Asn Thr Leu Lys Ser Val Asp Leu His Glu Ser Gly Lys Leu Gln 
                85                  90                  95      


His Gln Leu Ala Val Asp Leu Asp Arg Asn Ile Asn Ile Gln Trp Gln 
            100                 105                 110         


Lys Tyr Cys Tyr Pro Leu Ile Gly Ser Met Thr Tyr Ser Val Lys Glu 
        115                 120                 125             


Met Glu Tyr Leu Thr Arg Ala Ile Asp Arg Thr Gly Gly Glu Lys Asn 
    130                 135                 140                 


Thr Val Ile Val Ile Ser Leu Gly Gln His Phe Arg Pro Phe Pro Ile 
145                 150                 155                 160 


Asp Val Phe Ile Arg Arg Ala Leu Asn Val His Lys Ala Ile Gln His 
                165                 170                 175     


Leu Leu Leu Arg Ser Pro Asp Thr Met Val Ile Ile Lys Thr Glu Asn 
            180                 185                 190         


Ile Arg Glu Met Tyr Asn Asp Ala Glu Arg Phe Ser Asp Phe His Gly 
        195                 200                 205             


Tyr Ile Gln Tyr Leu Ile Ile Lys Asp Ile Phe Gln Asp Leu Ser Val 
    210                 215                 220                 


Ser Ile Ile Asp Ala Trp Asp Ile Thr Ile Ala Tyr Gly Thr Asn Asn 
225                 230                 235                 240 


Val His Pro Pro Gln His Val Val Gly Asn Gln Ile Asn Ile Leu Leu 
                245                 250                 255     


Asn Tyr Ile Cys 
            260 


<210>  9718
<211>  544
<212>  PRT
<213>  Homo Sapiens

<400>  9718

Met Lys Ile Ser Met Ile Asn Tyr Lys Ser Leu Leu Ala Leu Leu Phe 
1               5                   10                  15      


Ile Leu Ala Ser Trp Ile Ile Phe Thr Val Phe Gln Asn Ser Thr Lys 
            20                  25                  30          


Val Trp Ser Ala Leu Asn Leu Ser Ile Ser Leu His Tyr Trp Asn Asn 
        35                  40                  45              


Ser Thr Lys Ser Leu Phe Pro Lys Thr Pro Leu Ile Ser Leu Lys Pro 
    50                  55                  60                  


Leu Thr Glu Thr Glu Leu Arg Ile Lys Glu Ile Ile Glu Lys Leu Asp 
65                  70                  75                  80  


Gln Gln Ile Pro Pro Arg Pro Phe Thr His Val Asn Thr Thr Thr Ser 
                85                  90                  95      


Ala Thr His Ser Thr Ala Thr Ile Leu Asn Pro Arg Asp Thr Tyr Cys 
            100                 105                 110         


Arg Gly Asp Gln Leu His Ile Leu Leu Glu Val Arg Asp His Leu Gly 
        115                 120                 125             


Arg Arg Lys Gln Tyr Gly Gly Asp Phe Leu Arg Ala Arg Met Ser Ser 
    130                 135                 140                 


Pro Ala Leu Met Ala Gly Ala Ser Gly Lys Val Thr Asp Phe Asn Asn 
145                 150                 155                 160 


Gly Thr Tyr Leu Val Ser Phe Thr Leu Phe Trp Glu Gly Gln Val Ser 
                165                 170                 175     


Leu Ser Leu Leu Leu Ile His Pro Ser Glu Gly Val Ser Ala Leu Trp 
            180                 185                 190         


Ser Ala Arg Asn Gln Gly Tyr Asp Arg Val Ile Phe Thr Gly Gln Phe 
        195                 200                 205             


Val Asn Gly Thr Ser Gln Val His Ser Glu Cys Gly Leu Ile Leu Asn 
    210                 215                 220                 


Thr Asn Ala Glu Leu Cys Gln Tyr Leu Asp Asn Arg Asp Gln Glu Gly 
225                 230                 235                 240 


Phe Tyr Cys Val Arg Pro Gln His Met Pro Cys Ala Ala Leu Thr His 
                245                 250                 255     


Met Tyr Ser Lys Asn Lys Lys Val Ser Tyr Leu Ser Lys Gln Glu Lys 
            260                 265                 270         


Ser Leu Phe Glu Arg Ser Asn Val Gly Val Glu Ile Met Glu Lys Phe 
        275                 280                 285             


Asn Thr Ile Ser Val Ser Lys Cys Asn Lys Glu Thr Val Ala Met Lys 
    290                 295                 300                 


Glu Lys Cys Lys Phe Gly Met Thr Ser Thr Ile Pro Ser Gly His Val 
305                 310                 315                 320 


Trp Arg Asn Thr Trp Asn Pro Val Ser Cys Ser Leu Ala Thr Val Lys 
                325                 330                 335     


Met Lys Glu Cys Leu Arg Gly Lys Leu Ile Tyr Leu Met Gly Asp Ser 
            340                 345                 350         


Thr Ile Arg Gln Trp Met Glu Tyr Phe Lys Ala Ser Ile Asn Thr Leu 
        355                 360                 365             


Lys Ser Val Asp Leu His Glu Ser Gly Lys Leu Gln His Gln Leu Ala 
    370                 375                 380                 


Val Asp Leu Asp Arg Asn Ile Asn Ile Gln Trp Gln Lys Tyr Cys Tyr 
385                 390                 395                 400 


Pro Leu Ile Gly Ser Met Thr Tyr Ser Val Lys Glu Met Glu Tyr Leu 
                405                 410                 415     


Thr Arg Ala Ile Asp Arg Thr Gly Gly Glu Lys Asn Thr Val Ile Val 
            420                 425                 430         


Ile Ser Leu Gly Gln His Phe Arg Pro Phe Pro Ile Asp Val Phe Ile 
        435                 440                 445             


Arg Arg Ala Leu Asn Val His Lys Ala Ile Gln His Leu Leu Leu Arg 
    450                 455                 460                 


Ser Pro Asp Thr Met Val Ile Ile Lys Thr Glu Asn Ile Arg Glu Met 
465                 470                 475                 480 


Tyr Asn Asp Ala Glu Arg Phe Ser Asp Phe His Gly Tyr Ile Gln Tyr 
                485                 490                 495     


Leu Ile Ile Lys Asp Ile Phe Gln Asp Leu Ser Val Ser Ile Ile Asp 
            500                 505                 510         


Ala Trp Asp Ile Thr Ile Ala Tyr Gly Thr Asn Asn Val His Pro Pro 
        515                 520                 525             


Gln His Val Val Gly Asn Gln Ile Asn Ile Leu Leu Asn Tyr Ile Cys 
    530                 535                 540                 


<210>  9719
<211>  139
<212>  PRT
<213>  Homo Sapiens

<400>  9719

Met Gln Ala Ala Cys Trp Tyr Val Leu Phe Leu Leu Gln Pro Thr Val 
1               5                   10                  15      


Tyr Leu Val Thr Cys Ala Asn Leu Thr Asn Gly Gly Lys Ser Glu Leu 
            20                  25                  30          


Leu Lys Ser Gly Ser Ser Lys Ser Thr Leu Lys His Ile Trp Thr Glu 
        35                  40                  45              


Ser Ser Lys Asp Leu Ser Ile Ser Arg Leu Leu Ser Gln Thr Phe Arg 
    50                  55                  60                  


Gly Lys Glu Asn Asp Thr Asp Leu Asp Leu Arg Tyr Asp Thr Pro Glu 
65                  70                  75                  80  


Pro Tyr Ser Glu Gln Asp Leu Trp Asp Trp Leu Arg Asn Ser Thr Asp 
                85                  90                  95      


Leu Gln Glu Pro Arg Pro Arg Ala Lys Arg Arg Pro Ile Val Lys Thr 
            100                 105                 110         


Gly Lys Phe Lys Lys Met Phe Gly Trp Gly Asp Phe His Ser Asn Ile 
        115                 120                 125             


Lys Thr Val Lys Leu Asn Leu Leu Ile Thr Gly 
    130                 135                 


<210>  9720
<211>  143
<212>  PRT
<213>  Homo Sapiens

<400>  9720

Met Gln Ala Ala Cys Trp Tyr Val Leu Phe Leu Leu Gln Pro Thr Val 
1               5                   10                  15      


Tyr Leu Val Thr Cys Ala Asn Leu Thr Asn Gly Gly Lys Ser Glu Leu 
            20                  25                  30          


Leu Lys Ser Gly Ser Ser Lys Ser Thr Leu Lys His Ile Trp Thr Glu 
        35                  40                  45              


Ser Ser Lys Asp Leu Ser Ile Ser Arg Leu Leu Ser Gln Thr Phe Arg 
    50                  55                  60                  


Gly Lys Glu Asn Asp Thr Asp Leu Asp Leu Arg Tyr Asp Thr Pro Glu 
65                  70                  75                  80  


Pro Tyr Ser Glu Gln Asp Leu Trp Asp Trp Leu Arg Asn Ser Thr Asp 
                85                  90                  95      


Leu Gln Glu Pro Arg Pro Arg Ala Lys Arg Arg Pro Ile Val Lys Thr 
            100                 105                 110         


Gly Lys Phe Lys Lys Met Phe Gly Trp Gly Asp Phe His Ser Asn Ile 
        115                 120                 125             


Lys Thr Val Lys Leu Asn Leu Leu Ile Thr Gly Lys Ile Val Asp 
    130                 135                 140             


<210>  9721
<211>  271
<212>  PRT
<213>  Homo Sapiens

<400>  9721

Met Gln Ala Ala Cys Trp Tyr Val Leu Phe Leu Leu Gln Pro Thr Val 
1               5                   10                  15      


Tyr Leu Val Thr Cys Ala Asn Leu Thr Asn Gly Gly Lys Ser Glu Leu 
            20                  25                  30          


Leu Lys Ser Gly Ser Ser Lys Ser Thr Leu Lys His Ile Trp Thr Glu 
        35                  40                  45              


Ser Ser Lys Asp Leu Ser Ile Ser Arg Leu Leu Ser Gln Thr Phe Arg 
    50                  55                  60                  


Gly Lys Glu Asn Asp Thr Asp Leu Asp Leu Arg Tyr Asp Thr Pro Glu 
65                  70                  75                  80  


Pro Tyr Ser Glu Gln Asp Leu Trp Asp Trp Leu Arg Asn Ser Thr Asp 
                85                  90                  95      


Leu Gln Glu Pro Arg Pro Arg Ala Lys Arg Arg Pro Ile Val Lys Thr 
            100                 105                 110         


Gly Lys Phe Lys Lys Met Phe Gly Trp Gly Asp Phe His Ser Asn Ile 
        115                 120                 125             


Lys Thr Val Lys Leu Asn Leu Leu Ile Thr Gly Lys Ile Val Asp His 
    130                 135                 140                 


Gly Asn Gly Thr Phe Ser Val Tyr Phe Arg His Asn Ser Thr Gly Gln 
145                 150                 155                 160 


Gly Asn Val Ser Val Ser Leu Val Pro Pro Thr Lys Ile Val Glu Phe 
                165                 170                 175     


Asp Leu Ala Gln Gln Thr Val Ile Asp Ala Lys Asp Ser Lys Ser Phe 
            180                 185                 190         


Asn Cys Arg Ile Glu Tyr Glu Lys Val Asp Lys Ala Thr Lys Asn Thr 
        195                 200                 205             


Leu Cys Asn Tyr Asp Pro Ser Lys Thr Cys Tyr Gln Glu Gln Thr Gln 
    210                 215                 220                 


Ser His Val Ser Trp Leu Cys Ser Lys Pro Phe Lys Val Ile Cys Ile 
225                 230                 235                 240 


Tyr Ile Ser Phe Tyr Ser Thr Asp Tyr Lys Leu Val Gln Lys Val Cys 
                245                 250                 255     


Pro Asp Tyr Asn Tyr His Ser Asp Thr Pro Tyr Phe Pro Ser Gly 
            260                 265                 270     


<210>  9722
<211>  253
<212>  PRT
<213>  Homo Sapiens

<400>  9722

Val Thr Cys Ala Asn Leu Thr Asn Gly Gly Lys Ser Glu Leu Leu Lys 
1               5                   10                  15      


Ser Gly Ser Ser Lys Ser Thr Leu Lys His Ile Trp Thr Glu Ser Ser 
            20                  25                  30          


Lys Asp Leu Ser Ile Ser Arg Leu Leu Ser Gln Thr Phe Arg Gly Lys 
        35                  40                  45              


Glu Asn Asp Thr Asp Leu Asp Leu Arg Tyr Asp Thr Pro Glu Pro Tyr 
    50                  55                  60                  


Ser Glu Gln Asp Leu Trp Asp Trp Leu Arg Asn Ser Thr Asp Leu Gln 
65                  70                  75                  80  


Glu Pro Arg Pro Arg Ala Lys Arg Arg Pro Ile Val Lys Thr Gly Lys 
                85                  90                  95      


Phe Lys Lys Met Phe Gly Trp Gly Asp Phe His Ser Asn Ile Lys Thr 
            100                 105                 110         


Val Lys Leu Asn Leu Leu Ile Thr Gly Lys Ile Val Asp His Gly Asn 
        115                 120                 125             


Gly Thr Phe Ser Val Tyr Phe Arg His Asn Ser Thr Gly Gln Gly Asn 
    130                 135                 140                 


Val Ser Val Ser Leu Val Pro Pro Thr Lys Ile Val Glu Phe Asp Leu 
145                 150                 155                 160 


Ala Gln Gln Thr Val Ile Asp Ala Lys Asp Ser Lys Ser Phe Asn Cys 
                165                 170                 175     


Arg Ile Glu Tyr Glu Lys Val Asp Lys Ala Thr Lys Asn Thr Leu Cys 
            180                 185                 190         


Asn Tyr Asp Pro Ser Lys Thr Cys Tyr Gln Glu Gln Thr Gln Ser His 
        195                 200                 205             


Val Ser Trp Leu Cys Ser Lys Pro Phe Lys Val Ile Cys Ile Tyr Ile 
    210                 215                 220                 


Ser Phe Tyr Ser Thr Asp Tyr Lys Leu Val Gln Lys Val Cys Pro Asp 
225                 230                 235                 240 


Tyr Asn Tyr His Ser Asp Thr Pro Tyr Phe Pro Ser Gly 
                245                 250             


<210>  9723
<211>  264
<212>  PRT
<213>  Homo Sapiens

<400>  9723

Met Arg Leu Arg Pro Leu Pro Leu Val Val Val Pro Gly Leu Leu Gln 
1               5                   10                  15      


Leu Leu Phe Cys Asp Ser Lys Glu Val Val His Ala Thr Glu Gly Leu 
            20                  25                  30          


Asp Trp Glu Asp Lys Asp Ala Pro Gly Thr Leu Val Gly Asn Val Val 
        35                  40                  45              


His Ser Arg Ile Ile Ser Pro Leu Arg Leu Phe Val Lys Gln Ser Pro 
    50                  55                  60                  


Val Pro Lys Pro Gly Pro Met Ala Tyr Ala Asp Ser Met Glu Asn Phe 
65                  70                  75                  80  


Trp Asp Trp Leu Ala Asn Ile Thr Glu Ile Gln Glu Pro Leu Ala Arg 
                85                  90                  95      


Thr Lys Arg Arg Pro Ile Val Lys Thr Gly Lys Phe Lys Lys Met Phe 
            100                 105                 110         


Gly Trp Gly Asp Phe His Ser Asn Ile Lys Thr Val Lys Leu Asn Leu 
        115                 120                 125             


Leu Ile Thr Gly Lys Ile Val Asp His Gly Asn Gly Thr Phe Ser Val 
    130                 135                 140                 


Tyr Phe Arg His Asn Ser Thr Gly Leu Gly Asn Val Ser Val Ser Leu 
145                 150                 155                 160 


Val Pro Pro Ser Lys Val Val Glu Phe Glu Val Ser Pro Gln Ser Thr 
                165                 170                 175     


Leu Glu Thr Lys Glu Ser Lys Ser Phe Asn Cys Arg Ile Glu Tyr Glu 
            180                 185                 190         


Lys Thr Asp Arg Ala Lys Lys Thr Ala Leu Cys Asn Phe Asp Pro Ser 
        195                 200                 205             


Lys Ile Cys Tyr Gln Glu Gln Thr Gln Ser His Val Ser Trp Leu Cys 
    210                 215                 220                 


Ser Lys Pro Phe Lys Val Ile Cys Ile Tyr Ile Ala Phe Tyr Ser Val 
225                 230                 235                 240 


Asp Tyr Lys Leu Val Gln Lys Val Cys Pro Asp Tyr Asn Tyr His Ser 
                245                 250                 255     


Glu Thr Pro Tyr Leu Ser Ser Gly 
            260                 


<210>  9724
<211>  354
<212>  PRT
<213>  Homo Sapiens

<400>  9724

Met Gln Leu Thr Arg Cys Cys Phe Val Phe Leu Val Gln Gly Ser Leu 
1               5                   10                  15      


Tyr Leu Val Ile Cys Gly Gln Asp Asp Gly Pro Pro Gly Ser Glu Asp 
            20                  25                  30          


Pro Glu Arg Asp Asp His Glu Gly Gln Pro Arg Pro Arg Val Pro Arg 
        35                  40                  45              


Lys Arg Gly His Ile Ser Pro Lys Ser Arg Pro Met Ala Asn Ser Thr 
    50                  55                  60                  


Leu Leu Gly Leu Leu Ala Pro Pro Gly Glu Ala Trp Gly Ile Leu Gly 
65                  70                  75                  80  


Gln Pro Pro Asn Arg Pro Asn His Ser Pro Pro Pro Ser Ala Lys Val 
                85                  90                  95      


Lys Lys Ile Phe Gly Trp Gly Asp Phe Tyr Ser Asn Ile Lys Thr Val 
            100                 105                 110         


Ala Leu Asn Leu Leu Val Thr Gly Lys Ile Val Asp His Gly Asn Gly 
        115                 120                 125             


Thr Phe Ser Val His Phe Gln His Asn Ala Thr Gly Gln Gly Asn Ile 
    130                 135                 140                 


Ser Ile Ser Leu Val Pro Pro Ser Lys Ala Val Glu Phe His Gln Glu 
145                 150                 155                 160 


Gln Gln Ile Phe Ile Glu Ala Lys Ala Ser Lys Ile Phe Asn Cys Arg 
                165                 170                 175     


Met Glu Trp Glu Lys Val Glu Arg Gly Arg Arg Thr Ser Leu Cys Thr 
            180                 185                 190         


His Asp Pro Ala Lys Ile Cys Ser Arg Asp His Ala Gln Ser Ser Ala 
        195                 200                 205             


Thr Trp Ser Cys Ser Gln Pro Phe Lys Val Val Cys Val Tyr Ile Ala 
    210                 215                 220                 


Phe Tyr Ser Thr Asp Tyr Arg Leu Val Gln Lys Gly Pro Ser Leu Leu 
225                 230                 235                 240 


Ser Gly Asp Val Arg His Thr Pro Leu Leu Gln Thr Thr Leu Arg Ser 
                245                 250                 255     


Pro Pro Trp Arg Leu Glu Thr Ala Gly Thr Gly Ala Ala His Gln Trp 
            260                 265                 270         


Thr Pro Thr Val Cys Arg Ser Ala Ser His Ser Ala Val Glu Thr Ala 
        275                 280                 285             


Gly Arg Arg Arg Lys Gln Trp Gly Gln Arg Pro Trp Ala Pro Ser Pro 
    290                 295                 300                 


Pro Pro Leu Ala Glu Leu Ser Ala Gly Thr Gly Gly Thr Leu Thr Pro 
305                 310                 315                 320 


Leu Leu Leu Leu Ser Ser Cys Gly Glu Pro Asp Ala Gly Asp Ser Trp 
                325                 330                 335     


Arg Ala Arg Pro Ser Trp His Thr Val Leu Pro Ala Pro Gly Met Asp 
            340                 345                 350         


Ser Phe 
        


<210>  9725
<211>  252
<212>  PRT
<213>  Homo Sapiens

<400>  9725

Met Gln Leu Thr Arg Cys Cys Phe Val Phe Leu Val Gln Gly Ser Leu 
1               5                   10                  15      


Tyr Leu Val Ile Cys Gly Gln Asp Asp Gly Pro Pro Gly Ser Glu Asp 
            20                  25                  30          


Pro Glu Arg Asp Asp His Glu Gly Gln Pro Arg Pro Arg Val Pro Arg 
        35                  40                  45              


Lys Arg Gly His Ile Ser Pro Lys Ser Arg Pro Met Ala Asn Ser Thr 
    50                  55                  60                  


Leu Leu Gly Leu Leu Ala Pro Pro Gly Glu Ala Trp Gly Ile Leu Gly 
65                  70                  75                  80  


Gln Pro Pro Asn Arg Pro Asn His Ser Pro Pro Pro Ser Ala Lys Val 
                85                  90                  95      


Lys Lys Ile Phe Gly Trp Gly Asp Phe Tyr Ser Asn Ile Lys Thr Val 
            100                 105                 110         


Ala Leu Asn Leu Leu Val Thr Gly Lys Ile Val Asp His Gly Asn Gly 
        115                 120                 125             


Thr Phe Ser Val His Phe Gln His Asn Ala Thr Gly Gln Gly Asn Ile 
    130                 135                 140                 


Ser Ile Ser Leu Val Pro Pro Ser Lys Ala Val Glu Phe His Gln Glu 
145                 150                 155                 160 


Gln Gln Ile Phe Ile Glu Ala Lys Ala Ser Lys Ile Phe Asn Cys Arg 
                165                 170                 175     


Met Glu Trp Glu Lys Val Glu Arg Gly Arg Arg Thr Ser Leu Cys Thr 
            180                 185                 190         


His Asp Pro Ala Lys Ile Cys Ser Arg Asp His Ala Gln Ser Ser Ala 
        195                 200                 205             


Thr Trp Ser Cys Ser Gln Pro Phe Lys Val Val Cys Val Tyr Ile Ala 
    210                 215                 220                 


Phe Tyr Ser Thr Asp Tyr Arg Leu Val Gln Lys Val Cys Pro Asp Tyr 
225                 230                 235                 240 


Asn Tyr His Ser Asp Thr Pro Tyr Tyr Pro Ser Gly 
                245                 250         


<210>  9726
<211>  308
<212>  PRT
<213>  Homo Sapiens

<400>  9726

Met Arg Leu Leu Pro Glu Trp Phe Leu Leu Leu Phe Gly Pro Trp Leu 
1               5                   10                  15      


Leu Arg Lys Ala Val Ser Ala Gln Ile Pro Glu Ser Gly Arg Pro Gln 
            20                  25                  30          


Tyr Leu Gly Leu Arg Pro Ala Ala Ala Gly Ala Gly Ala Pro Gly Gln 
        35                  40                  45              


Gln Leu Pro Glu Pro Arg Ser Ser Asp Gly Leu Gly Val Gly Arg Ala 
    50                  55                  60                  


Trp Ser Trp Ala Trp Pro Thr Asn His Thr Gly Ala Leu Ala Arg Ala 
65                  70                  75                  80  


Gly Ala Ala Gly Ala Leu Pro Ala Gln Arg Thr Lys Arg Lys Pro Ser 
                85                  90                  95      


Ile Lys Ala Ala Arg Ala Lys Lys Ile Phe Gly Trp Gly Asp Phe Tyr 
            100                 105                 110         


Phe Arg Val His Thr Leu Lys Phe Ser Leu Leu Val Thr Gly Lys Ile 
        115                 120                 125             


Val Asp His Val Asn Gly Thr Phe Ser Val Tyr Phe Arg His Asn Ser 
    130                 135                 140                 


Ser Ser Leu Gly Asn Leu Ser Val Ser Ile Val Pro Pro Ser Lys Arg 
145                 150                 155                 160 


Val Glu Phe Gly Gly Val Trp Leu Pro Gly Pro Val Pro His Pro Leu 
                165                 170                 175     


Gln Ser Thr Leu Ala Leu Glu Gly Val Leu Pro Gly Leu Gly Pro Pro 
            180                 185                 190         


Leu Gly Met Ala Ala Ala Ala Ala Gly Pro Gly Leu Gly Gly Ser Leu 
        195                 200                 205             


Gly Gly Ala Leu Ala Gly Pro Leu Gly Gly Ala Leu Gly Val Pro Gly 
    210                 215                 220                 


Ala Lys Glu Ser Arg Ala Phe Asn Cys His Val Glu Tyr Glu Lys Thr 
225                 230                 235                 240 


Asn Arg Ala Arg Lys His Arg Pro Cys Leu Tyr Asp Pro Ser Gln Val 
                245                 250                 255     


Cys Phe Thr Glu His Thr Gln Ser Gln Ala Ala Trp Leu Cys Ala Lys 
            260                 265                 270         


Pro Phe Lys Val Ile Cys Ile Phe Val Ser Phe Leu Ser Phe Asp Tyr 
        275                 280                 285             


Lys Leu Val Gln Lys Val Cys Pro Asp Tyr Asn Phe Gln Ser Glu His 
    290                 295                 300                 


Pro Tyr Phe Gly 
305             


<210>  9727
<211>  36
<212>  PRT
<213>  Homo Sapiens

<400>  9727

Met Arg Leu Leu Pro Glu Trp Phe Leu Leu Leu Phe Gly Pro Trp Leu 
1               5                   10                  15      


Leu Arg Lys Pro Arg Pro Gly Leu Ser Leu Pro Pro Ala Arg Ser Trp 
            20                  25                  30          


Glu His Pro Ala 
        35      


<210>  9728
<211>  481
<212>  PRT
<213>  Homo Sapiens

<400>  9728

Met Lys Gly Arg Gly Met Leu Val Leu Leu Leu His Ala Val Val Leu 
1               5                   10                  15      


Gly Leu Pro Ser Ala Trp Ala Val Gly Ala Cys Ala Arg Ala Cys Pro 
            20                  25                  30          


Ala Ala Cys Ala Cys Ser Thr Val Glu Arg Gly Cys Ser Val Arg Cys 
        35                  40                  45              


Asp Arg Ala Gly Leu Leu Arg Val Pro Ala Glu Leu Pro Cys Glu Ala 
    50                  55                  60                  


Val Ser Ile Asp Leu Asp Arg Asn Gly Leu Arg Phe Leu Gly Glu Arg 
65                  70                  75                  80  


Ala Phe Gly Thr Leu Pro Ser Leu Arg Arg Leu Ser Leu Arg His Asn 
                85                  90                  95      


Asn Leu Ser Phe Ile Thr Pro Gly Ala Phe Lys Gly Leu Pro Arg Leu 
            100                 105                 110         


Ala Glu Leu Arg Leu Ala His Asn Gly Asp Leu Arg Tyr Leu His Ala 
        115                 120                 125             


Arg Thr Phe Ala Ala Leu Ser Arg Leu Arg Arg Leu Asp Leu Ala Ala 
    130                 135                 140                 


Cys Arg Leu Phe Ser Val Pro Glu Arg Leu Leu Ala Glu Leu Pro Ala 
145                 150                 155                 160 


Leu Arg Glu Leu Ala Ala Phe Asp Asn Leu Phe Arg Arg Val Pro Gly 
                165                 170                 175     


Ala Leu Arg Gly Leu Ala Asn Leu Thr His Ala His Leu Glu Arg Gly 
            180                 185                 190         


Arg Ile Glu Ala Val Ala Ser Ser Ser Leu Gln Gly Leu Arg Arg Leu 
        195                 200                 205             


Arg Ser Leu Ser Leu Gln Ala Asn Arg Val Arg Ala Val His Ala Gly 
    210                 215                 220                 


Ala Phe Gly Asp Cys Gly Val Leu Glu His Leu Leu Leu Asn Asp Asn 
225                 230                 235                 240 


Leu Leu Ala Glu Leu Pro Ala Asp Ala Phe Arg Gly Leu Arg Arg Leu 
                245                 250                 255     


Arg Thr Leu Asn Leu Gly Gly Asn Ala Leu Asp Arg Val Ala Arg Ala 
            260                 265                 270         


Trp Phe Ala Asp Leu Ala Glu Leu Glu Leu Leu Tyr Leu Asp Arg Asn 
        275                 280                 285             


Ser Ile Ala Phe Val Glu Glu Gly Ala Phe Gln Asn Leu Ser Gly Leu 
    290                 295                 300                 


Leu Ala Leu His Leu Asn Gly Asn Arg Leu Thr Val Leu Ala Trp Val 
305                 310                 315                 320 


Ala Phe Gln Pro Gly Phe Phe Leu Gly Arg Leu Phe Leu Phe Arg Asn 
                325                 330                 335     


Pro Trp Cys Cys Asp Cys Arg Leu Glu Trp Leu Arg Asp Trp Met Glu 
            340                 345                 350         


Gly Ser Gly Arg Val Thr Asp Val Pro Cys Ala Ser Pro Gly Ser Val 
        355                 360                 365             


Ala Gly Leu Asp Leu Ser Gln Val Thr Phe Gly Arg Ser Ser Asp Gly 
    370                 375                 380                 


Leu Cys Val Asp Pro Glu Glu Leu Asn Leu Thr Thr Ser Ser Pro Gly 
385                 390                 395                 400 


Pro Ser Pro Glu Pro Ala Ala Thr Thr Val Ser Arg Phe Ser Ser Leu 
                405                 410                 415     


Leu Ser Lys Leu Leu Ala Pro Arg Val Pro Val Glu Glu Ala Ala Asn 
            420                 425                 430         


Thr Thr Gly Gly Leu Ala Asn Ala Ser Leu Ser Asp Ser Leu Ser Ser 
        435                 440                 445             


Arg Gly Val Gly Gly Ala Gly Arg Gln Pro Trp Phe Leu Leu Ala Ser 
    450                 455                 460                 


Cys Leu Leu Pro Ser Val Ala Gln His Val Val Phe Gly Leu Gln Met 
465                 470                 475                 480 


Asp 
    


<210>  9729
<211>  481
<212>  PRT
<213>  Homo Sapiens

<400>  9729

Met Lys Gly Arg Gly Met Leu Val Leu Leu Leu His Ala Val Val Leu 
1               5                   10                  15      


Gly Leu Pro Ser Ala Trp Ala Val Gly Ala Cys Ala Arg Ala Cys Pro 
            20                  25                  30          


Ala Ala Cys Ala Cys Ser Thr Val Glu Arg Gly Cys Ser Val Arg Cys 
        35                  40                  45              


Asp Arg Ala Gly Leu Leu Arg Val Pro Ala Glu Leu Pro Cys Glu Ala 
    50                  55                  60                  


Val Ser Ile Asp Leu Asp Arg Asn Gly Leu Arg Phe Leu Gly Glu Arg 
65                  70                  75                  80  


Ala Phe Gly Thr Leu Pro Ser Leu Arg Arg Leu Ser Leu Arg His Asn 
                85                  90                  95      


Asn Leu Ser Phe Ile Thr Pro Gly Ala Phe Lys Gly Leu Pro Arg Leu 
            100                 105                 110         


Ala Glu Leu Arg Leu Ala His Asn Gly Asp Leu Arg Tyr Leu His Ala 
        115                 120                 125             


Arg Thr Phe Ala Ala Leu Ser Arg Leu Arg Arg Leu Asp Leu Ala Ala 
    130                 135                 140                 


Cys Arg Leu Phe Ser Val Pro Glu Arg Leu Leu Ala Glu Leu Pro Ala 
145                 150                 155                 160 


Leu Arg Glu Leu Ala Ala Phe Asp Asn Leu Phe Arg Arg Val Pro Gly 
                165                 170                 175     


Ala Leu Arg Gly Leu Ala Asn Leu Thr His Ala His Leu Glu Arg Gly 
            180                 185                 190         


Arg Ile Glu Ala Val Ala Ser Ser Ser Leu Gln Gly Leu Arg Arg Leu 
        195                 200                 205             


Arg Ser Leu Ser Leu Gln Ala Asn Arg Val Arg Ala Val His Ala Gly 
    210                 215                 220                 


Ala Phe Gly Asp Cys Gly Val Leu Glu His Leu Leu Leu Asn Asp Asn 
225                 230                 235                 240 


Leu Leu Ala Glu Leu Pro Ala Asp Ala Phe Arg Gly Leu Arg Arg Leu 
                245                 250                 255     


Arg Thr Leu Asn Leu Gly Gly Asn Ala Leu Asp Arg Val Ala Arg Ala 
            260                 265                 270         


Trp Phe Ala Asp Leu Ala Glu Leu Glu Leu Leu Tyr Leu Asp Arg Asn 
        275                 280                 285             


Ser Ile Ala Phe Val Glu Glu Gly Ala Phe Gln Asn Leu Ser Gly Leu 
    290                 295                 300                 


Leu Ala Leu His Leu Asn Gly Asn Arg Leu Thr Val Leu Ala Trp Val 
305                 310                 315                 320 


Ala Phe Gln Pro Gly Phe Phe Leu Gly Arg Leu Phe Leu Phe Arg Asn 
                325                 330                 335     


Pro Trp Cys Cys Asp Cys Arg Leu Glu Trp Leu Arg Asp Trp Met Glu 
            340                 345                 350         


Gly Ser Gly Arg Val Thr Asp Val Pro Cys Ala Ser Pro Gly Ser Val 
        355                 360                 365             


Ala Gly Leu Asp Leu Ser Gln Val Thr Phe Gly Arg Ser Ser Asp Gly 
    370                 375                 380                 


Leu Cys Val Asp Pro Glu Glu Leu Asn Leu Thr Thr Ser Ser Pro Gly 
385                 390                 395                 400 


Pro Ser Pro Glu Pro Ala Ala Thr Thr Val Ser Arg Phe Ser Ser Leu 
                405                 410                 415     


Leu Ser Lys Leu Leu Ala Pro Arg Val Pro Val Glu Glu Ala Ala Asn 
            420                 425                 430         


Thr Thr Gly Gly Leu Ala Asn Ala Ser Leu Ser Asp Ser Leu Ser Ser 
        435                 440                 445             


Arg Gly Val Gly Gly Ala Gly Arg Gln Pro Trp Phe Leu Leu Ala Ser 
    450                 455                 460                 


Cys Leu Leu Pro Ser Val Ala Gln His Val Val Phe Gly Leu Gln Met 
465                 470                 475                 480 


Asp 
    


<210>  9730
<211>  157
<212>  PRT
<213>  Homo Sapiens

<400>  9730

Met Ala Lys Leu Arg Gln Lys Asn Pro Arg Ala Val Arg Gln Ala Glu 
1               5                   10                  15      


Glu Val Arg Gly Leu Glu His Leu His Met Asp Val Ala Val Asn Phe 
            20                  25                  30          


Ser Gln Gly Ala Leu Leu Ser Pro His Leu His Asn Val Cys Ala Glu 
        35                  40                  45              


Ala Val Asp Ala Ile Tyr Thr Arg Gln Glu Asp Val Arg Phe Trp Leu 
    50                  55                  60                  


Glu Gln Gly Val Asp Ser Ser Val Phe Glu Ala Leu Pro Lys Ala Ser 
65                  70                  75                  80  


Glu Gln Ala Glu Leu Pro Arg Cys Arg Gln Val Gly Asp His Gly Lys 
                85                  90                  95      


Pro Cys Val Cys Arg Tyr Gly Leu Ser Leu Ala Trp Tyr Pro Cys Met 
            100                 105                 110         


Leu Lys Tyr Cys His Ser Arg Asp Arg Pro Thr Pro Tyr Lys Cys Gly 
        115                 120                 125             


Ile Arg Ser Cys Gln Lys Ser Tyr Ser Phe Asp Phe Tyr Val Pro Gln 
    130                 135                 140                 


Arg Gln Leu Cys Leu Trp Asp Glu Asp Pro Tyr Pro Gly 
145                 150                 155         


<210>  9731
<211>  273
<212>  PRT
<213>  Homo Sapiens

<400>  9731

Met Arg Leu Pro Gly Val Pro Leu Ala Arg Pro Ala Leu Leu Leu Leu 
1               5                   10                  15      


Leu Pro Leu Leu Ala Pro Leu Leu Gly Thr Gly Ala Pro Ala Glu Leu 
            20                  25                  30          


Arg Val Arg Val Arg Leu Pro Asp Gly Gln Val Thr Glu Glu Ser Leu 
        35                  40                  45              


Gln Ala Asp Ser Asp Ala Asp Ser Ile Ser Leu Glu Leu Arg Lys Pro 
    50                  55                  60                  


Asp Gly Thr Leu Val Ser Phe Thr Ala Asp Phe Lys Lys Asp Val Lys 
65                  70                  75                  80  


Val Phe Arg Ala Leu Ile Leu Gly Glu Leu Glu Lys Gly Gln Ser Gln 
                85                  90                  95      


Phe Gln Ala Leu Cys Phe Val Thr Gln Leu Gln His Asn Glu Ile Ile 
            100                 105                 110         


Pro Ser Glu Ala Met Ala Lys Leu Arg Gln Lys Asn Pro Arg Ala Val 
        115                 120                 125             


Arg Gln Ala Glu Glu Val Arg Gly Leu Glu His Leu His Met Asp Val 
    130                 135                 140                 


Ala Val Asn Phe Ser Gln Gly Ala Leu Leu Ser Pro His Leu His Asn 
145                 150                 155                 160 


Val Cys Ala Glu Ala Val Asp Ala Ile Tyr Thr Arg Gln Glu Asp Val 
                165                 170                 175     


Arg Phe Trp Leu Glu Gln Gly Val Asp Ser Ser Val Phe Glu Ala Leu 
            180                 185                 190         


Pro Lys Ala Ser Glu Gln Ala Glu Leu Pro Arg Cys Arg Gln Val Gly 
        195                 200                 205             


Asp His Gly Lys Pro Cys Val Cys Arg Tyr Gly Leu Ser Leu Ala Trp 
    210                 215                 220                 


Tyr Pro Cys Met Leu Lys Tyr Cys His Ser Arg Asp Arg Pro Thr Pro 
225                 230                 235                 240 


Tyr Lys Cys Gly Ile Arg Ser Cys Gln Lys Ser Tyr Ser Phe Asp Phe 
                245                 250                 255     


Tyr Val Pro Gln Arg Gln Leu Cys Leu Trp Asp Glu Asp Pro Tyr Pro 
            260                 265                 270         


Gly 
    


<210>  9732
<211>  85
<212>  PRT
<213>  Homo Sapiens

<400>  9732

Met Lys Thr Leu Phe Leu Gly Val Thr Leu Gly Leu Ala Ala Ala Leu 
1               5                   10                  15      


Ser Phe Thr Leu Glu Glu Glu Asp Glu Gly Gly Ser Val His Pro Glu 
            20                  25                  30          


Glu Asn Pro Asp Ala Glu Asp Gly Gly Ala Trp Gln Ile Gln Arg Leu 
        35                  40                  45              


Trp Gly Gln Glu Ala His Ile Pro Ala Gly Ala Ala Arg Asp Gly Arg 
    50                  55                  60                  


Leu Arg Leu Leu Leu Gln Arg Pro Ala Pro Trp Gly Pro Ala Leu His 
65                  70                  75                  80  


Gly Lys Ala Cys Gly 
                85  


<210>  9733
<211>  147
<212>  PRT
<213>  Homo Sapiens

<400>  9733

Met Lys Thr Leu Phe Leu Gly Val Thr Leu Gly Leu Ala Ala Ala Leu 
1               5                   10                  15      


Ser Phe Thr Leu Glu Glu Glu Asp Glu Gly Gly Ser Val His Pro Glu 
            20                  25                  30          


Glu Asn Pro Asp Ala Glu Asp Gly Gly Ala Trp Gln Ile Gln Arg Leu 
        35                  40                  45              


Trp Gly Gln Glu Ala His Ile Pro Ala Gly Ala Ala Arg Asp Gly Arg 
    50                  55                  60                  


Leu Arg Leu Leu Leu Gln Arg Pro Ala Pro Trp Gly Pro Ala Leu His 
65                  70                  75                  80  


Gly Lys Ala Cys Gly Ile Cys Ser Leu Gln Gly Arg Ala Ala Val Pro 
                85                  90                  95      


Thr Leu Ala His Leu Ala Thr Ser Pro Ala Gly Arg Asn Pro Asn Thr 
            100                 105                 110         


Asn Leu Glu Ala Leu Glu Glu Phe Lys Lys Leu Val Gln His Lys Gly 
        115                 120                 125             


Leu Ser Glu Glu Asp Ile Phe Met Pro Leu Gln Thr Gly Ser Cys Val 
    130                 135                 140                 


Leu Glu His 
145         


<210>  9734
<211>  228
<212>  PRT
<213>  Homo Sapiens

<400>  9734

Met Lys Thr Leu Phe Leu Gly Val Thr Leu Gly Leu Ala Ala Ala Leu 
1               5                   10                  15      


Ser Phe Thr Leu Glu Glu Glu Asp Ile Thr Gly Thr Trp Tyr Val Lys 
            20                  25                  30          


Ala Met Val Val Asp Lys Asp Phe Pro Glu Asp Arg Arg Pro Arg Lys 
        35                  40                  45              


Val Ser Pro Val Lys Val Thr Ala Leu Gly Gly Gly Asn Leu Glu Ala 
    50                  55                  60                  


Thr Phe Thr Phe Met Arg Glu Asp Arg Cys Ile Gln Lys Lys Ile Leu 
65                  70                  75                  80  


Met Arg Lys Thr Glu Glu Pro Gly Lys Phe Ser Ala Tyr Gly Gly Arg 
                85                  90                  95      


Lys Leu Ile Tyr Leu Gln Glu Leu Pro Gly Thr Asp Asp Tyr Val Phe 
            100                 105                 110         


Tyr Cys Lys Asp Gln Arg Arg Gly Gly Leu Arg Tyr Met Gly Lys Leu 
        115                 120                 125             


Val Ala Ser Ala Pro Cys Arg Ala Val Pro Leu Ser Pro Pro Trp Leu 
    130                 135                 140                 


Thr Trp Pro Pro His Leu Gln Val Gly Ile Leu Ile Pro Thr Trp Arg 
145                 150                 155                 160 


Pro Trp Lys Asn Leu Arg Asn Trp Cys Ser Thr Arg Asp Ser Arg Arg 
                165                 170                 175     


Arg Thr Phe Ser Cys Pro Cys Arg Arg Glu Ala Ala Phe Ser Asn Thr 
            180                 185                 190         


Arg Gln Pro Pro Gly Leu His Leu Gln Ser Pro Pro Tyr His Gln Thr 
        195                 200                 205             


Gln Ser Pro Asp His Leu Asp Leu Pro Ser Ser His Asp Pro Ser Leu 
    210                 215                 220                 


Leu Pro Pro Thr 
225             


<210>  9735
<211>  220
<212>  PRT
<213>  Homo Sapiens

<400>  9735

Met Lys Thr Leu Phe Leu Gly Val Thr Leu Gly Leu Ala Ala Ala Leu 
1               5                   10                  15      


Ser Phe Thr Leu Glu Glu Glu Asp Ile Thr Gly Thr Trp Tyr Val Lys 
            20                  25                  30          


Ala Met Val Val Asp Lys Asp Phe Pro Glu Asp Arg Arg Pro Arg Lys 
        35                  40                  45              


Val Ser Pro Val Lys Val Thr Ala Leu Gly Gly Gly Asn Leu Glu Ala 
    50                  55                  60                  


Thr Phe Thr Phe Met Arg Glu Asp Arg Cys Ile Gln Lys Lys Ile Leu 
65                  70                  75                  80  


Met Arg Lys Thr Glu Glu Pro Gly Lys Phe Ser Ala Tyr Gly Gly Arg 
                85                  90                  95      


Lys Leu Ile Tyr Leu Gln Glu Leu Pro Gly Thr Asp Asp Tyr Val Phe 
            100                 105                 110         


Tyr Cys Lys Asp Gln Arg Arg Gly Gly Leu Arg Tyr Met Gly Lys Leu 
        115                 120                 125             


Val Ala Ser Ala Pro Cys Arg Ala Val Pro Leu Ser Pro Pro Trp Leu 
    130                 135                 140                 


Thr Trp Pro Pro His Leu Gln Val Gly Ile Leu Ile Pro Thr Trp Arg 
145                 150                 155                 160 


Pro Trp Lys Asn Leu Arg Asn Trp Cys Ser Thr Arg Asp Ser Arg Arg 
                165                 170                 175     


Arg Thr Phe Ser Cys Pro Cys Arg Arg Glu Ala Ala Phe Ser Asn Thr 
            180                 185                 190         


Arg Val Thr Pro Gly Ser Ala Pro Pro Glu Pro Thr Leu Pro Pro Asp 
        195                 200                 205             


Thr Glu Pro Gly Pro Pro Gly Pro Thr Leu Gln Pro 
    210                 215                 220 


<210>  9736
<211>  146
<212>  PRT
<213>  Homo Sapiens

<400>  9736

Met Lys Thr Leu Phe Leu Gly Val Thr Leu Gly Leu Ala Ala Ala Leu 
1               5                   10                  15      


Ser Phe Thr Leu Glu Glu Glu Asp Ile Thr Gly Thr Trp Tyr Val Lys 
            20                  25                  30          


Ala Met Val Val Asp Lys Asp Phe Pro Glu Asp Arg Arg Pro Arg Lys 
        35                  40                  45              


Val Ser Pro Val Lys Val Thr Ala Leu Gly Gly Gly Asn Leu Glu Ala 
    50                  55                  60                  


Thr Phe Thr Phe Met Arg Glu Asp Arg Cys Ile Gln Lys Lys Ile Leu 
65                  70                  75                  80  


Met Arg Lys Thr Glu Glu Pro Gly Lys Phe Ser Ala Tyr Gly Gly Arg 
                85                  90                  95      


Lys Leu Ile Tyr Leu Gln Glu Leu Pro Gly Thr Asp Asp Tyr Val Phe 
            100                 105                 110         


Tyr Cys Lys Asp Gln Arg Arg Gly Gly Leu Arg Tyr Met Gly Lys Leu 
        115                 120                 125             


Val Gly Pro Cys Arg Cys Pro His Leu Gly Ser Pro Gly His Leu Thr 
    130                 135                 140                 


Cys Arg 
145     


<210>  9737
<211>  170
<212>  PRT
<213>  Homo Sapiens

<400>  9737

Met Lys Thr Leu Phe Leu Gly Val Thr Leu Gly Leu Ala Ala Ala Leu 
1               5                   10                  15      


Ser Phe Thr Leu Glu Glu Glu Asp Ile Thr Gly Thr Trp Tyr Val Lys 
            20                  25                  30          


Ala Met Val Val Asp Lys Asp Phe Pro Glu Asp Arg Arg Pro Arg Lys 
        35                  40                  45              


Val Ser Pro Val Lys Val Thr Ala Leu Gly Gly Gly Asn Leu Glu Ala 
    50                  55                  60                  


Thr Phe Thr Phe Met Arg Glu Asp Arg Cys Ile Gln Lys Lys Ile Leu 
65                  70                  75                  80  


Met Arg Lys Thr Glu Glu Pro Gly Lys Phe Ser Ala Tyr Gly Gly Arg 
                85                  90                  95      


Lys Leu Ile Tyr Leu Gln Glu Leu Pro Gly Thr Asp Asp Tyr Val Phe 
            100                 105                 110         


Tyr Cys Lys Asp Gln Arg Arg Gly Gly Leu Arg Tyr Met Gly Lys Leu 
        115                 120                 125             


Val Gly Arg Asn Pro Asn Thr Asn Leu Glu Ala Leu Glu Glu Phe Lys 
    130                 135                 140                 


Lys Leu Val Gln His Lys Gly Leu Ser Glu Glu Asp Ile Phe Met Pro 
145                 150                 155                 160 


Leu Gln Thr Gly Ser Cys Val Leu Glu His 
                165                 170 


<210>  9738
<211>  170
<212>  PRT
<213>  Homo Sapiens

<400>  9738

Met Lys Thr Leu Phe Leu Gly Val Thr Leu Gly Leu Ala Ala Ala Leu 
1               5                   10                  15      


Ser Phe Thr Leu Glu Glu Glu Asp Ile Thr Gly Thr Trp Tyr Val Lys 
            20                  25                  30          


Ala Met Val Val Asp Lys Asp Phe Pro Glu Asp Arg Arg Pro Arg Lys 
        35                  40                  45              


Val Ser Pro Val Lys Val Thr Ala Leu Gly Gly Gly Asn Leu Glu Ala 
    50                  55                  60                  


Thr Phe Thr Phe Met Arg Glu Asp Arg Cys Ile Gln Lys Lys Ile Leu 
65                  70                  75                  80  


Met Arg Lys Thr Glu Glu Pro Gly Lys Phe Ser Ala Tyr Gly Gly Arg 
                85                  90                  95      


Lys Leu Ile Tyr Leu Gln Glu Leu Pro Gly Thr Asp Asp Tyr Val Phe 
            100                 105                 110         


Tyr Cys Lys Asp Gln Arg Arg Gly Gly Leu Arg Tyr Met Gly Lys Leu 
        115                 120                 125             


Val Gly Arg Asn Pro Asn Thr Asn Leu Glu Ala Leu Glu Glu Phe Lys 
    130                 135                 140                 


Lys Leu Val Gln His Lys Gly Leu Ser Glu Glu Asp Ile Phe Met Pro 
145                 150                 155                 160 


Leu Gln Thr Gly Ser Cys Val Leu Glu His 
                165                 170 


<210>  9739
<211>  165
<212>  PRT
<213>  Homo Sapiens

<400>  9739

Met Lys Thr Leu Phe Leu Gly Val Thr Leu Gly Leu Ala Ala Ala Leu 
1               5                   10                  15      


Ser Phe Thr Leu Glu Glu Glu Asp Ile Thr Gly Thr Trp Tyr Val Lys 
            20                  25                  30          


Ala Met Val Val Asp Lys Asp Phe Pro Glu Asp Arg Arg Pro Arg Lys 
        35                  40                  45              


Val Ser Pro Val Lys Val Thr Ala Leu Gly Gly Gly Lys Leu Glu Ala 
    50                  55                  60                  


Thr Phe Thr Phe Met Arg Glu Asp Arg Cys Ile Gln Lys Lys Ile Leu 
65                  70                  75                  80  


Met Arg Lys Thr Glu Glu Pro Gly Lys Tyr Ser Ala Cys Leu Ser Ala 
                85                  90                  95      


Val Glu Met Asp Gln Ile Thr Pro Ala Leu Trp Glu Ala Leu Ala Ile 
            100                 105                 110         


Asp Thr Leu Arg Lys Leu Arg Ile Gly Thr Arg Arg Pro Arg Ile Arg 
        115                 120                 125             


Trp Gly Gln Glu Ala His Val Pro Ala Gly Ala Ala Gln Glu Gly Pro 
    130                 135                 140                 


Leu His Leu Leu Leu Gln Arg Pro Ala Pro Trp Gly Pro Ala Pro His 
145                 150                 155                 160 


Gly Lys Ala Cys Gly 
                165 


<210>  9740
<211>  220
<212>  PRT
<213>  Homo Sapiens

<400>  9740

Met Lys Thr Leu Phe Leu Gly Val Thr Leu Gly Leu Ala Ala Ala Leu 
1               5                   10                  15      


Ser Phe Thr Leu Glu Glu Glu Asp Ile Thr Gly Thr Trp Tyr Val Lys 
            20                  25                  30          


Ala Met Val Val Asp Lys Asp Phe Pro Glu Asp Arg Arg Pro Arg Lys 
        35                  40                  45              


Val Ser Pro Val Lys Val Thr Ala Leu Gly Gly Gly Lys Leu Glu Ala 
    50                  55                  60                  


Thr Phe Thr Phe Met Arg Glu Asp Arg Cys Ile Gln Lys Lys Ile Leu 
65                  70                  75                  80  


Met Arg Lys Thr Glu Glu Pro Gly Lys Tyr Ser Ala Tyr Gly Gly Arg 
                85                  90                  95      


Lys Leu Met Tyr Leu Gln Glu Leu Pro Arg Arg Asp His Tyr Ile Phe 
            100                 105                 110         


Tyr Cys Lys Asp Gln His His Gly Gly Leu Leu His Met Gly Lys Leu 
        115                 120                 125             


Val Ala Ser Ala Pro Cys Arg Ala Val Pro Leu Ser Pro Arg Arg Leu 
    130                 135                 140                 


Thr Trp Pro Pro His Leu Gln Val Gly Ile Leu Ile Pro Thr Gly Arg 
145                 150                 155                 160 


Pro Trp Lys Asn Leu Arg Asn Trp Cys Ser Ala Arg Asp Ser Arg Arg 
                165                 170                 175     


Arg Thr Phe Ser Arg Pro Cys Arg Arg Glu Ala Ala Phe Pro Asn Thr 
            180                 185                 190         


Arg Gln Ala Pro Gly Ser Ala Pro Pro Glu Pro Thr Leu Pro Pro Asp 
        195                 200                 205             


Thr Glu Pro Gly Pro Pro Gly Pro Thr Leu Gln Pro 
    210                 215                 220 


<210>  9741
<211>  170
<212>  PRT
<213>  Homo Sapiens

<400>  9741

Met Lys Thr Leu Phe Leu Gly Val Thr Leu Gly Leu Ala Ala Ala Leu 
1               5                   10                  15      


Ser Phe Thr Leu Glu Glu Glu Asp Ile Thr Gly Thr Trp Tyr Val Lys 
            20                  25                  30          


Ala Met Val Val Asp Lys Asp Phe Pro Glu Asp Arg Arg Pro Arg Lys 
        35                  40                  45              


Val Ser Pro Val Lys Val Thr Ala Leu Gly Gly Gly Lys Leu Glu Ala 
    50                  55                  60                  


Thr Phe Thr Phe Met Arg Glu Asp Arg Cys Ile Gln Lys Lys Ile Leu 
65                  70                  75                  80  


Met Arg Lys Thr Glu Glu Pro Gly Lys Tyr Ser Ala Tyr Gly Gly Arg 
                85                  90                  95      


Lys Leu Met Tyr Leu Gln Glu Leu Pro Arg Arg Asp His Tyr Ile Phe 
            100                 105                 110         


Tyr Cys Lys Asp Gln His His Gly Gly Leu Leu His Met Gly Lys Leu 
        115                 120                 125             


Val Gly Arg Asn Ser Asp Thr Asn Arg Glu Ala Leu Glu Glu Phe Lys 
    130                 135                 140                 


Lys Leu Val Gln Arg Lys Gly Leu Ser Glu Glu Asp Ile Phe Thr Pro 
145                 150                 155                 160 


Leu Gln Thr Gly Ser Cys Val Pro Glu His 
                165                 170 


<210>  9742
<211>  170
<212>  PRT
<213>  Homo Sapiens

<400>  9742

Met Lys Thr Leu Phe Leu Gly Val Thr Leu Gly Leu Ala Ala Ala Leu 
1               5                   10                  15      


Ser Phe Thr Leu Glu Glu Glu Asp Ile Thr Gly Thr Trp Tyr Val Lys 
            20                  25                  30          


Ala Met Val Val Asp Lys Asp Phe Pro Glu Asp Arg Arg Pro Arg Lys 
        35                  40                  45              


Val Ser Pro Val Lys Val Thr Ala Leu Gly Gly Gly Lys Leu Glu Ala 
    50                  55                  60                  


Thr Phe Thr Phe Met Arg Glu Asp Arg Cys Ile Gln Lys Lys Ile Leu 
65                  70                  75                  80  


Met Arg Lys Thr Glu Glu Pro Gly Lys Tyr Ser Ala Tyr Gly Gly Arg 
                85                  90                  95      


Lys Leu Met Tyr Leu Gln Glu Leu Pro Arg Arg Asp His Tyr Ile Phe 
            100                 105                 110         


Tyr Cys Lys Asp Gln His His Gly Gly Leu Leu His Met Gly Lys Leu 
        115                 120                 125             


Val Gly Arg Asn Ser Asp Thr Asn Arg Glu Ala Leu Glu Glu Phe Lys 
    130                 135                 140                 


Lys Leu Val Gln Arg Lys Gly Leu Ser Glu Glu Asp Ile Phe Thr Pro 
145                 150                 155                 160 


Leu Gln Thr Gly Ser Cys Val Pro Glu His 
                165                 170 


<210>  9743
<211>  477
<212>  PRT
<213>  Homo Sapiens

<400>  9743

Met Ile Ala Phe Leu Leu Thr Ser Val Leu Met Ile Pro His Ala Gly 
1               5                   10                  15      


Gly His Pro Leu Asp Thr Pro His Leu Pro Gln Glu Leu Pro Pro Gly 
            20                  25                  30          


Leu Pro Asn Asn Ile Asn Ile Thr Phe Phe Ser Gly Met Phe Lys Asn 
        35                  40                  45              


Val Glu Ser Val Ala Glu Ile Phe Asp Cys Leu Gly Pro His Phe Thr 
    50                  55                  60                  


Trp Leu Gln Ala Val Phe Thr Asn Phe Pro Val Leu Ile Gln Phe Val 
65                  70                  75                  80  


Asn Gly Met Lys Cys Val Ala Gly Leu Cys Pro Arg Asp Phe Glu Asp 
                85                  90                  95      


Tyr Gly Cys Thr Cys Arg Phe Glu Met Glu Gly Leu Pro Val Asp Glu 
            100                 105                 110         


Ser Asp Ser Cys Cys Phe Gln His Arg Arg Cys Tyr Glu Glu Ala Ala 
        115                 120                 125             


Glu Met Asp Cys Leu Gln Asp Pro Ala Lys Leu Ser Thr Glu Val Asn 
    130                 135                 140                 


Cys Val Ser Lys Lys Ile Ile Cys Glu Ser Lys Asp Asn Cys Glu His 
145                 150                 155                 160 


Leu Leu Cys Thr Cys Asp Lys Ala Ala Ile Glu Cys Leu Ala Arg Ser 
                165                 170                 175     


Ser Leu Asn Ser Ser Leu Asn Leu Leu Asp Thr Ser Phe Cys Leu Ala 
            180                 185                 190         


Gln Thr Pro Glu Thr Thr Ile Lys Glu Asp Leu Thr Thr Leu Leu Pro 
        195                 200                 205             


Arg Val Val Pro Val Glu Pro Thr Asp Thr Ser Leu Thr Ala Leu Ser 
    210                 215                 220                 


Gly Glu Glu Ala Gly His Asp Gln Glu Gly Val Gly Ala Ala Arg Ala 
225                 230                 235                 240 


Thr Ser Pro Pro Gly Ser Ala Glu Ile Val Ala Thr Arg Val Thr Ala 
                245                 250                 255     


Lys Ile Val Thr Leu Val Pro Ala Gly Ile Lys Ser Leu Gly Leu Ala 
            260                 265                 270         


Val Ser Ser Val Glu Asn Asp Pro Glu Glu Thr Thr Glu Lys Ala Cys 
        275                 280                 285             


Asp Arg Phe Thr Phe Leu His Leu Gly Ser Gly Asp Asn Met Gln Val 
    290                 295                 300                 


Met Pro Gln Leu Gly Glu Met Leu Phe Cys Leu Thr Ser Arg Cys Pro 
305                 310                 315                 320 


Glu Glu Phe Glu Ser Tyr Gly Cys Tyr Cys Gly Gln Glu Gly Arg Gly 
                325                 330                 335     


Glu Pro Arg Asp Asp Leu Asp Arg Cys Cys Leu Ser His His Cys Cys 
            340                 345                 350         


Leu Glu Gln Val Arg Arg Leu Gly Cys Leu Leu Glu Arg Leu Pro Trp 
        355                 360                 365             


Ser Pro Val Val Cys Val Asp His Thr Pro Lys Cys Gly Gly Gln Ser 
    370                 375                 380                 


Leu Cys Glu Lys Leu Leu Cys Ala Cys Asp Gln Thr Ala Ala Glu Cys 
385                 390                 395                 400 


Met Thr Ser Ala Ser Phe Asn Gln Ser Leu Lys Ser Pro Ser Arg Leu 
                405                 410                 415     


Gly Cys Pro Gly Gln Pro Ala Ala Cys Glu Asp Ser Leu His Pro Val 
            420                 425                 430         


Pro Ala Ala Pro Thr Leu Gly Ser Ser Ser Glu Glu Asp Ser Glu Glu 
        435                 440                 445             


Asp Pro Pro Gln Glu Asp Leu Gly Arg Ala Lys Arg Phe Leu Arg Lys 
    450                 455                 460                 


Ser Leu Gly Pro Leu Gly Ile Gly Pro Leu His Gly Arg 
465                 470                 475         


<210>  9744
<211>  271
<212>  PRT
<213>  Homo Sapiens

<400>  9744

Met Ile Ile Val Ala Phe Ala Leu Ile Ile Phe Phe Ala Val Lys Thr 
1               5                   10                  15      


Arg Arg Lys Met Asp Arg Tyr Asp Lys Ser Asn Ile Leu Trp Asp Lys 
            20                  25                  30          


Glu His Ile Tyr Asp Glu Gln Pro Pro Asn Val Glu Glu Trp Val Lys 
        35                  40                  45              


Asn Val Ser Ala Gly Thr Gln Asp Val Pro Ser Pro Pro Ser Asp Tyr 
    50                  55                  60                  


Val Glu Arg Val Asp Ser Pro Met Ala Tyr Ser Ser Asn Gly Lys Val 
65                  70                  75                  80  


Asn Asp Lys Arg Phe Tyr Pro Glu Ser Ser Tyr Lys Ser Thr Pro Val 
                85                  90                  95      


Pro Glu Val Val Gln Glu Leu Pro Leu Thr Ser Pro Val Asp Asp Phe 
            100                 105                 110         


Arg Gln Pro Arg Tyr Ser Ser Gly Gly Asn Phe Glu Thr Pro Ser Lys 
        115                 120                 125             


Arg Ala Pro Ala Lys Gly Arg Ala Gly Arg Ser Lys Arg Thr Glu Gln 
    130                 135                 140                 


Asp His Tyr Glu Thr Asp Tyr Thr Thr Gly Gly Glu Ser Cys Asp Glu 
145                 150                 155                 160 


Leu Glu Glu Asp Trp Ile Arg Glu Tyr Pro Pro Ile Thr Ser Asp Gln 
                165                 170                 175     


Gln Arg Gln Leu Tyr Lys Arg Asn Phe Asp Thr Gly Leu Gln Glu Tyr 
            180                 185                 190         


Lys Ser Leu Gln Ser Glu Leu Asp Glu Ile Asn Lys Glu Leu Ser Arg 
        195                 200                 205             


Leu Asp Lys Glu Leu Asp Asp Tyr Arg Glu Glu Ser Glu Glu Tyr Met 
    210                 215                 220                 


Ala Ala Ala Asp Glu Tyr Asn Arg Leu Lys Gln Val Lys Gly Ser Ala 
225                 230                 235                 240 


Asp Tyr Lys Ser Lys Lys Asn His Cys Lys Gln Leu Lys Ser Lys Leu 
                245                 250                 255     


Ser His Ile Lys Lys Met Val Gly Asp Tyr Asp Arg Gln Lys Thr 
            260                 265                 270     


<210>  9745
<211>  522
<212>  PRT
<213>  Homo Sapiens

<400>  9745

Met Ser Ser Arg Pro Leu Glu Ser Pro Pro Pro Tyr Arg Pro Asp Glu 
1               5                   10                  15      


Phe Lys Pro Asn His Tyr Ala Pro Ser Asn Asp Ile Tyr Gly Gly Glu 
            20                  25                  30          


Met His Val Arg Pro Met Leu Ser Gln Pro Ala Tyr Ser Phe Tyr Pro 
        35                  40                  45              


Glu Asp Glu Ile Leu His Phe Tyr Lys Trp Thr Ser Pro Pro Gly Val 
    50                  55                  60                  


Ile Arg Ile Leu Ser Met Leu Ile Ile Val Met Cys Ile Ala Ile Phe 
65                  70                  75                  80  


Ala Cys Val Ala Ser Thr Leu Ala Trp Asp Arg Gly Tyr Gly Thr Ser 
                85                  90                  95      


Leu Leu Gly Gly Ser Val Gly Tyr Pro Tyr Gly Gly Ser Gly Phe Gly 
            100                 105                 110         


Ser Tyr Gly Ser Gly Tyr Gly Tyr Gly Tyr Gly Tyr Gly Tyr Gly Tyr 
        115                 120                 125             


Gly Gly Tyr Thr Asp Pro Arg Ala Ala Lys Gly Phe Met Leu Ala Met 
    130                 135                 140                 


Ala Ala Phe Cys Phe Ile Ala Ala Leu Val Ile Phe Val Thr Ser Val 
145                 150                 155                 160 


Ile Arg Ser Glu Met Ser Arg Thr Arg Arg Tyr Tyr Leu Ser Val Ile 
                165                 170                 175     


Ile Val Ser Ala Ile Leu Gly Ile Met Val Phe Ile Ala Thr Ile Val 
            180                 185                 190         


Tyr Ile Met Gly Val Asn Pro Thr Ala Gln Ser Ser Gly Ser Leu Tyr 
        195                 200                 205             


Gly Ser Gln Ile Tyr Ala Leu Cys Asn Gln Phe Tyr Thr Pro Ala Ala 
    210                 215                 220                 


Thr Gly Leu Tyr Val Asp Gln Tyr Leu Tyr His Tyr Cys Val Val Asp 
225                 230                 235                 240 


Pro Gln Glu Ala Ile Ala Ile Val Leu Gly Phe Met Ile Ile Val Ala 
                245                 250                 255     


Phe Ala Leu Ile Ile Phe Phe Ala Val Lys Thr Arg Arg Lys Met Asp 
            260                 265                 270         


Arg Tyr Asp Lys Ser Asn Ile Leu Trp Asp Lys Glu His Ile Tyr Asp 
        275                 280                 285             


Glu Gln Pro Pro Asn Val Glu Glu Trp Val Lys Asn Val Ser Ala Gly 
    290                 295                 300                 


Thr Gln Asp Val Pro Ser Pro Pro Ser Asp Tyr Val Glu Arg Val Asp 
305                 310                 315                 320 


Ser Pro Met Ala Tyr Ser Ser Asn Gly Lys Val Asn Asp Lys Arg Phe 
                325                 330                 335     


Tyr Pro Glu Ser Ser Tyr Lys Ser Thr Pro Val Pro Glu Val Val Gln 
            340                 345                 350         


Glu Leu Pro Leu Thr Ser Pro Val Asp Asp Phe Arg Gln Pro Arg Tyr 
        355                 360                 365             


Ser Ser Gly Gly Asn Phe Glu Thr Pro Ser Lys Arg Ala Pro Ala Lys 
    370                 375                 380                 


Gly Arg Ala Gly Arg Ser Lys Arg Thr Glu Gln Asp His Tyr Glu Thr 
385                 390                 395                 400 


Asp Tyr Thr Thr Gly Gly Glu Ser Cys Asp Glu Leu Glu Glu Asp Trp 
                405                 410                 415     


Ile Arg Glu Tyr Pro Pro Ile Thr Ser Asp Gln Gln Arg Gln Leu Tyr 
            420                 425                 430         


Lys Arg Asn Phe Asp Thr Gly Leu Gln Glu Tyr Lys Ser Leu Gln Ser 
        435                 440                 445             


Glu Leu Asp Glu Ile Asn Lys Glu Leu Ser Arg Leu Asp Lys Glu Leu 
    450                 455                 460                 


Asp Asp Tyr Arg Glu Glu Ser Glu Glu Tyr Met Ala Ala Ala Asp Glu 
465                 470                 475                 480 


Tyr Asn Arg Leu Lys Gln Val Lys Gly Ser Ala Asp Tyr Lys Ser Lys 
                485                 490                 495     


Lys Asn His Cys Lys Gln Leu Lys Ser Lys Leu Ser His Ile Lys Lys 
            500                 505                 510         


Met Val Gly Asp Tyr Asp Arg Gln Lys Thr 
        515                 520         


<210>  9746
<211>  522
<212>  PRT
<213>  Homo Sapiens

<400>  9746

Met Ser Ser Arg Pro Leu Glu Ser Pro Pro Pro Tyr Arg Pro Asp Glu 
1               5                   10                  15      


Phe Lys Pro Asn His Tyr Ala Pro Ser Asn Asp Ile Tyr Gly Gly Glu 
            20                  25                  30          


Met His Val Arg Pro Met Leu Ser Gln Pro Ala Tyr Ser Phe Tyr Pro 
        35                  40                  45              


Glu Asp Glu Ile Leu His Phe Tyr Lys Trp Thr Ser Pro Pro Gly Val 
    50                  55                  60                  


Ile Arg Ile Leu Ser Met Leu Ile Ile Val Met Cys Ile Ala Ile Phe 
65                  70                  75                  80  


Ala Cys Val Ala Ser Thr Leu Ala Trp Asp Arg Gly Tyr Gly Thr Ser 
                85                  90                  95      


Leu Leu Gly Gly Ser Val Gly Tyr Pro Tyr Gly Gly Ser Gly Phe Gly 
            100                 105                 110         


Ser Tyr Gly Ser Gly Tyr Gly Tyr Gly Tyr Gly Tyr Gly Tyr Gly Tyr 
        115                 120                 125             


Gly Gly Tyr Thr Asp Pro Arg Ala Ala Lys Gly Phe Met Leu Ala Met 
    130                 135                 140                 


Ala Ala Phe Cys Phe Ile Ala Ala Leu Val Ile Phe Val Thr Ser Val 
145                 150                 155                 160 


Ile Arg Ser Glu Met Ser Arg Thr Arg Arg Tyr Tyr Leu Ser Val Ile 
                165                 170                 175     


Ile Val Ser Ala Ile Leu Gly Ile Met Val Phe Ile Ala Thr Ile Val 
            180                 185                 190         


Tyr Ile Met Gly Val Asn Pro Thr Ala Gln Ser Ser Gly Ser Leu Tyr 
        195                 200                 205             


Gly Ser Gln Ile Tyr Ala Leu Cys Asn Gln Phe Tyr Thr Pro Ala Ala 
    210                 215                 220                 


Thr Gly Leu Tyr Val Asp Gln Tyr Leu Tyr His Tyr Cys Val Val Asp 
225                 230                 235                 240 


Pro Gln Glu Ala Ile Ala Ile Val Leu Gly Phe Met Ile Ile Val Ala 
                245                 250                 255     


Phe Ala Leu Ile Ile Phe Phe Ala Val Lys Thr Arg Arg Lys Met Asp 
            260                 265                 270         


Arg Tyr Asp Lys Ser Asn Ile Leu Trp Asp Lys Glu His Ile Tyr Asp 
        275                 280                 285             


Glu Gln Pro Pro Asn Val Glu Glu Trp Val Lys Asn Val Ser Ala Gly 
    290                 295                 300                 


Thr Gln Asp Val Pro Ser Pro Pro Ser Asp Tyr Val Glu Arg Val Asp 
305                 310                 315                 320 


Ser Pro Met Ala Tyr Ser Ser Asn Gly Lys Val Asn Asp Lys Arg Phe 
                325                 330                 335     


Tyr Pro Glu Ser Ser Tyr Lys Ser Thr Pro Val Pro Glu Val Val Gln 
            340                 345                 350         


Glu Leu Pro Leu Thr Ser Pro Val Asp Asp Phe Arg Gln Pro Arg Tyr 
        355                 360                 365             


Ser Ser Gly Gly Asn Phe Glu Thr Pro Ser Lys Arg Ala Pro Ala Lys 
    370                 375                 380                 


Gly Arg Ala Gly Arg Ser Lys Arg Thr Glu Gln Asp His Tyr Glu Thr 
385                 390                 395                 400 


Asp Tyr Thr Thr Gly Gly Glu Ser Cys Asp Glu Leu Glu Glu Asp Trp 
                405                 410                 415     


Ile Arg Glu Tyr Pro Pro Ile Thr Ser Asp Gln Gln Arg Gln Leu Tyr 
            420                 425                 430         


Lys Arg Asn Phe Asp Thr Gly Leu Gln Glu Tyr Lys Ser Leu Gln Ser 
        435                 440                 445             


Glu Leu Asp Glu Ile Asn Lys Glu Leu Ser Arg Leu Asp Lys Glu Leu 
    450                 455                 460                 


Asp Asp Tyr Arg Glu Glu Ser Glu Glu Tyr Met Ala Ala Ala Asp Glu 
465                 470                 475                 480 


Tyr Asn Arg Leu Lys Gln Val Lys Gly Ser Ala Asp Tyr Lys Ser Lys 
                485                 490                 495     


Lys Asn His Cys Lys Gln Leu Lys Ser Lys Leu Ser His Ile Lys Lys 
            500                 505                 510         


Met Val Gly Asp Tyr Asp Arg Gln Lys Thr 
        515                 520         


<210>  9747
<211>  216
<212>  PRT
<213>  Homo Sapiens

<400>  9747

Gly Pro Leu Asn Ser Trp Ile Pro Pro Phe Ser Gly Ile Leu Gln Gln 
1               5                   10                  15      


Gln Gln Gln Ala Gln Ile Pro Gly Leu Ser Gln Phe Ser Leu Ser Ala 
            20                  25                  30          


Leu Asp Gln Phe Ala Gly Leu Leu Pro Asn Gln Ile Pro Leu Thr Gly 
        35                  40                  45              


Glu Ala Ser Phe Ala Gln Gly Ala Gln Ala Gly Gln Val Asp Pro Leu 
    50                  55                  60                  


Gln Leu Gln Thr Pro Pro Gln Thr Gln Pro Gly Pro Ser His Val Met 
65                  70                  75                  80  


Pro Tyr Val Phe Ser Phe Lys Met Pro Gln Glu Gln Gly Gln Met Phe 
                85                  90                  95      


Gln Tyr Tyr Pro Val Tyr Met Val Leu Pro Trp Glu Gln Pro Gln Gln 
            100                 105                 110         


Thr Val Pro Arg Ser Pro Gln Gln Thr Arg Gln Gln Gln Tyr Glu Glu 
        115                 120                 125             


Gln Ala Ile Ser Gly Gly Gln Gln Gln Leu Ala Phe Asp Pro Gln Leu 
    130                 135                 140                 


Gly Thr Ala Pro Glu Ile Ala Val Met Ser Thr Gly Glu Glu Ile Pro 
145                 150                 155                 160 


Tyr Leu Gln Lys Glu Ala Ile Asn Phe Arg His Asp Ser Ala Gly Val 
                165                 170                 175     


Phe Met Pro Ser Thr Ser Pro Lys Pro Ser Thr Thr Asn Val Phe Thr 
            180                 185                 190         


Ser Ala Val Asp Gln Thr Ile Thr Pro Glu Leu Pro Glu Glu Lys Asp 
        195                 200                 205             


Lys Thr Asp Ser Leu Arg Glu Pro 
    210                 215     


<210>  9748
<211>  279
<212>  PRT
<213>  Homo Sapiens

<400>  9748

Met Lys Ile Ile Ile Leu Leu Gly Phe Leu Gly Ala Thr Leu Ser Ala 
1               5                   10                  15      


Pro Leu Ile Pro Gln Arg Leu Met Ser Ala Ser Asn Ser Asn Glu Leu 
            20                  25                  30          


Leu Leu Asn Leu Asn Asn Gly Gln Leu Leu Pro Leu Gln Leu Gln Gly 
        35                  40                  45              


Pro Leu Asn Ser Trp Ile Pro Pro Phe Ser Gly Ile Leu Gln Gln Gln 
    50                  55                  60                  


Gln Gln Ala Gln Ile Pro Gly Leu Ser Gln Phe Ser Leu Ser Ala Leu 
65                  70                  75                  80  


Asp Gln Phe Ala Gly Leu Leu Pro Asn Gln Ile Pro Leu Thr Gly Glu 
                85                  90                  95      


Ala Ser Phe Ala Gln Gly Ala Gln Ala Gly Gln Val Asp Pro Leu Gln 
            100                 105                 110         


Leu Gln Thr Pro Pro Gln Thr Gln Pro Gly Pro Ser His Val Met Pro 
        115                 120                 125             


Tyr Val Phe Ser Phe Lys Met Pro Gln Glu Gln Gly Gln Met Phe Gln 
    130                 135                 140                 


Tyr Tyr Pro Val Tyr Met Val Leu Pro Trp Glu Gln Pro Gln Gln Thr 
145                 150                 155                 160 


Val Pro Arg Ser Pro Gln Gln Thr Arg Gln Gln Gln Tyr Glu Glu Gln 
                165                 170                 175     


Ile Pro Phe Tyr Ala Gln Phe Gly Tyr Ile Pro Gln Leu Ala Glu Pro 
            180                 185                 190         


Ala Ile Ser Gly Gly Gln Gln Gln Leu Ala Phe Asp Pro Gln Leu Gly 
        195                 200                 205             


Thr Ala Pro Glu Ile Ala Val Met Ser Thr Gly Glu Glu Ile Pro Tyr 
    210                 215                 220                 


Leu Gln Lys Glu Ala Ile Asn Phe Arg His Asp Ser Ala Gly Val Phe 
225                 230                 235                 240 


Met Pro Ser Thr Ser Pro Lys Pro Ser Thr Thr Asn Val Phe Thr Ser 
                245                 250                 255     


Ala Val Asp Gln Thr Ile Thr Pro Glu Leu Pro Glu Glu Lys Asp Lys 
            260                 265                 270         


Thr Asp Ser Leu Arg Glu Pro 
        275                 


<210>  9749
<211>  253
<212>  PRT
<213>  Homo Sapiens

<400>  9749

Met Lys Ile Ile Ile Leu Leu Gly Phe Leu Gly Ala Thr Leu Ser Ala 
1               5                   10                  15      


Pro Leu Leu Leu Asn Leu Asn Asn Gly Gln Leu Leu Pro Leu Gln Leu 
            20                  25                  30          


Gln Gly Pro Leu Asn Ser Trp Ile Pro Pro Phe Ser Gly Ile Leu Gln 
        35                  40                  45              


Gln Gln Gln Gln Ala Gln Ile Pro Gly Leu Ser Gln Phe Ser Leu Ser 
    50                  55                  60                  


Ala Leu Asp Gln Phe Ala Gly Leu Leu Pro Asn Gln Ile Pro Leu Thr 
65                  70                  75                  80  


Gly Glu Ala Ser Phe Ala Gln Gly Ala Gln Ala Gly Gln Val Asp Pro 
                85                  90                  95      


Leu Gln Leu Gln Thr Pro Pro Gln Thr Gln Pro Gly Pro Ser His Val 
            100                 105                 110         


Met Pro Tyr Val Phe Ser Phe Lys Met Pro Gln Glu Gln Gly Gln Met 
        115                 120                 125             


Phe Gln Tyr Tyr Pro Val Tyr Met Val Leu Pro Trp Glu Gln Pro Gln 
    130                 135                 140                 


Gln Thr Val Pro Arg Ser Pro Gln Gln Thr Arg Gln Gln Gln Tyr Glu 
145                 150                 155                 160 


Glu Gln Ile Pro Phe Tyr Ala Gln Phe Gly Tyr Ile Pro Gln Leu Ala 
                165                 170                 175     


Glu Pro Ala Ile Ser Gly Gly Gln Gln Gln Leu Ala Phe Asp Pro Gln 
            180                 185                 190         


Leu Gly Thr Ala Pro Glu Ile Ala Val Met Ser Thr Gly Glu Glu Ile 
        195                 200                 205             


Pro Tyr Leu Gln Lys Glu Ala Ile Asn Phe Arg His Asp Ser Ala Gly 
    210                 215                 220                 


Val Phe Met Pro Ser Thr Ser Pro Lys Pro Ser Thr Thr Asn Val Phe 
225                 230                 235                 240 


Thr Ser Ala Val Asp Gln Thr Ile Thr Pro Glu Leu Pro 
                245                 250             


<210>  9750
<211>  30
<212>  PRT
<213>  Homo Sapiens

<400>  9750

Gln Thr Pro Pro Gln Thr Gln Pro Gly Pro Ser His Val Met Pro Tyr 
1               5                   10                  15      


Val Phe Ser Phe Lys Met Pro Gln Glu Gln Gly Gln Asn Ile 
            20                  25                  30  


<210>  9751
<211>  176
<212>  PRT
<213>  Homo Sapiens

<400>  9751

Met Ala Arg Arg His Cys Phe Ser Tyr Trp Leu Leu Val Cys Trp Leu 
1               5                   10                  15      


Val Val Thr Val Ala Glu Ala Leu Ser Thr Phe Tyr Leu Gln Gln His 
            20                  25                  30          


Ile Asn Leu His Met Asp Lys Lys Arg Tyr Leu Arg Leu Leu Glu Ile 
        35                  40                  45              


His Lys Ile Met Arg Thr Leu Pro Thr Ala Arg Ser Leu His Ser Pro 
    50                  55                  60                  


Leu His Leu Pro Arg Gly Val Arg Ser Gln Gly Pro Ser Pro Ser Gln 
65                  70                  75                  80  


Arg His Pro Gly Val Pro Ser Ile Phe Phe His Glu Gly Pro Glu Ser 
                85                  90                  95      


Ile Leu Gly Phe Gln Thr Asp Leu Ser Ser Leu Gln Gly Val Thr Thr 
            100                 105                 110         


Val Phe His Ser Ser His Phe Ile Gly His Thr Val Thr Leu Leu Ile 
        115                 120                 125             


Gly Ile Ser Pro Glu Glu Asp Ser Arg Glu Glu Ala His Leu Arg Lys 
    130                 135                 140                 


Ala Glu Arg Glu Glu Lys Pro Lys His Thr Glu Ala Lys Lys Ser Leu 
145                 150                 155                 160 


Ser Phe Arg Lys Lys Gln Gln Lys Asp Phe Cys Phe Ile Phe Arg Asn 
                165                 170                 175     


<210>  9752
<211>  130
<212>  PRT
<213>  Homo Sapiens

<400>  9752

Met Ala Arg Arg His Cys Phe Ser Tyr Trp Leu Leu Val Cys Trp Leu 
1               5                   10                  15      


Val Val Thr Val Ala Glu Gly Gln Glu Glu Val Phe Thr Pro Pro Gly 
            20                  25                  30          


Asp Ser Gln Asn Asn Ala Asp Ala Thr Asp Cys Gln Ile Phe Thr Leu 
        35                  40                  45              


Thr Pro Pro Pro Ala Pro Arg Ser Pro Val Thr Arg Ala Gln Pro Ile 
    50                  55                  60                  


Thr Lys Thr Pro Arg Cys Pro Phe His Phe Phe Pro Arg Arg Pro Arg 
65                  70                  75                  80  


Ile His Phe Arg Phe Pro Asn Arg Pro Phe Val Pro Ser Arg Cys Asn 
                85                  90                  95      


His Arg Phe Pro Phe Gln Pro Phe Tyr Trp Pro His Arg Tyr Leu Thr 
            100                 105                 110         


Tyr Arg Tyr Phe Pro Arg Arg Arg Leu Gln Arg Gly Ser Ser Ser Glu 
        115                 120                 125             


Glu Ser 
    130 


<210>  9753
<211>  85
<212>  PRT
<213>  Homo Sapiens

<400>  9753

Met Ala Arg Arg His Cys Phe Ser Tyr Trp Leu Leu Val Cys Trp Leu 
1               5                   10                  15      


Val Val Thr Val Ala Glu Gly Gln Glu Glu Val Phe Thr Pro Pro Gly 
            20                  25                  30          


Asp Ser Gln Asn Asn Ala Asp Ala Thr Asp Cys Gln Ile Phe Thr Leu 
        35                  40                  45              


Thr Pro Pro Pro Ala Pro Arg Ser Pro Val Thr Arg Ala Gln Pro Ile 
    50                  55                  60                  


Thr Lys Thr Pro Arg Tyr Phe Pro Arg Arg Arg Leu Gln Arg Gly Ser 
65                  70                  75                  80  


Ser Ser Glu Glu Ser 
                85  


<210>  9754
<211>  40
<212>  PRT
<213>  Homo Sapiens

<400>  9754

Met Ala Arg Arg His Cys Phe Ser Tyr Trp Leu Leu Val Cys Trp Leu 
1               5                   10                  15      


Val Val Thr Val Ala Glu Val Glu Thr Gly Phe His His Val Ser Gln 
            20                  25                  30          


Asp Gly Leu Asp Leu Leu Thr Ser 
        35                  40  


<210>  9755
<211>  52
<212>  PRT
<213>  Homo Sapiens

<400>  9755

Met Pro Ala Arg Ala Leu Leu Pro Arg Arg Met Gly His Arg Thr Leu 
1               5                   10                  15      


Ala Ser Thr Pro Ala Leu Trp Ala Ser Ile Pro Cys Pro Arg Ser Glu 
            20                  25                  30          


Leu Arg Leu Asp Leu Val Leu Pro Ser Gly Gln Ser Phe Arg Trp Leu 
        35                  40                  45              


Thr Ala Ser Ala 
    50          


<210>  9756
<211>  357
<212>  PRT
<213>  Homo Sapiens

<400>  9756

Met Pro Ala Arg Ala Leu Leu Pro Arg Arg Met Gly His Arg Thr Leu 
1               5                   10                  15      


Ala Ser Thr Pro Ala Leu Trp Ala Ser Ile Pro Cys Pro Arg Ser Glu 
            20                  25                  30          


Leu Arg Leu Asp Leu Val Leu Pro Ser Gly Gln Ser Phe Arg Trp Arg 
        35                  40                  45              


Glu Gln Ser Pro Ala His Trp Ser Gly Val Leu Ala Asp Gln Val Trp 
    50                  55                  60                  


Thr Leu Thr Gln Thr Glu Glu Gln Leu His Cys Thr Val Tyr Arg Gly 
65                  70                  75                  80  


Asp Lys Ser Gln Ala Ser Arg Pro Thr Pro Asp Glu Leu Glu Ala Val 
                85                  90                  95      


Arg Lys Tyr Phe Gln Leu Asp Val Thr Leu Ala Gln Leu Tyr His His 
            100                 105                 110         


Trp Gly Ser Val Asp Ser His Phe Gln Glu Val Ala Gln Lys Phe Gln 
        115                 120                 125             


Gly Val Arg Leu Leu Arg Gln Asp Pro Ile Glu Cys Leu Phe Ser Phe 
    130                 135                 140                 


Ile Cys Ser Ser Asn Asn Asn Ile Ala Arg Ile Thr Gly Met Val Glu 
145                 150                 155                 160 


Arg Leu Cys Gln Ala Phe Gly Pro Arg Leu Ile Gln Leu Asp Asp Val 
                165                 170                 175     


Thr Tyr His Gly Phe Pro Ser Leu Gln Ala Leu Ala Gly Pro Glu Val 
            180                 185                 190         


Glu Ala His Leu Arg Lys Leu Gly Leu Gly Tyr Arg Ala Arg Tyr Val 
        195                 200                 205             


Ser Ala Ser Ala Arg Ala Ile Leu Glu Glu Gln Gly Gly Leu Ala Trp 
    210                 215                 220                 


Leu Gln Gln Leu Arg Glu Ser Ser Tyr Glu Glu Ala His Lys Ala Leu 
225                 230                 235                 240 


Cys Ile Leu Pro Gly Val Gly Thr Lys Gly Leu Leu Gly Asn Ala Phe 
                245                 250                 255     


Asp Gly His Gln Leu Leu Arg Pro Leu Ile Phe Cys Gln Asp His Leu 
            260                 265                 270         


Arg Glu Gly Pro Pro Ile Gly Arg Gly Asp Ser Gln Gly Glu Glu Leu 
        275                 280                 285             


Glu Pro Gln Leu Pro Ser Ser Leu Ser Ser Ile Pro Tyr Gly Phe Cys 
    290                 295                 300                 


Asp His Cys Trp Thr Lys Asp Val Asp Asp Pro Pro Leu Val Thr His 
305                 310                 315                 320 


Pro Ser Pro Gly Ser Arg Asp Gly His Met Thr Gln Ala Trp Pro Val 
                325                 330                 335     


Lys Val Val Ser Pro Leu Ala Thr Val Ile Gly His Val Met Gln Ala 
            340                 345                 350         


Ser Leu Leu Ala Leu 
        355         


<210>  9757
<211>  424
<212>  PRT
<213>  Homo Sapiens

<400>  9757

Met Pro Ala Arg Ala Leu Leu Pro Arg Arg Met Gly His Arg Thr Leu 
1               5                   10                  15      


Ala Ser Thr Pro Ala Leu Trp Ala Ser Ile Pro Cys Pro Arg Ser Glu 
            20                  25                  30          


Leu Arg Leu Asp Leu Val Leu Pro Ser Gly Gln Ser Phe Arg Trp Arg 
        35                  40                  45              


Glu Gln Ser Pro Ala His Trp Ser Gly Val Leu Ala Asp Gln Val Trp 
    50                  55                  60                  


Thr Leu Thr Gln Thr Glu Glu Gln Leu His Cys Thr Val Tyr Arg Gly 
65                  70                  75                  80  


Asp Lys Ser Gln Ala Ser Arg Pro Thr Pro Asp Glu Leu Glu Ala Val 
                85                  90                  95      


Arg Lys Tyr Phe Gln Leu Asp Val Thr Leu Ala Gln Leu Tyr His His 
            100                 105                 110         


Trp Gly Ser Val Asp Ser His Phe Gln Glu Val Ala Gln Lys Phe Gln 
        115                 120                 125             


Gly Val Arg Leu Leu Arg Gln Asp Pro Ile Glu Cys Leu Phe Ser Phe 
    130                 135                 140                 


Ile Cys Ser Ser Asn Asn Asn Ile Ala Arg Ile Thr Gly Met Val Glu 
145                 150                 155                 160 


Arg Leu Cys Gln Ala Phe Gly Pro Arg Leu Ile Gln Leu Asp Asp Val 
                165                 170                 175     


Thr Tyr His Gly Phe Pro Ser Leu Gln Ala Leu Ala Gly Pro Glu Val 
            180                 185                 190         


Glu Ala His Leu Arg Lys Leu Gly Leu Gly Tyr Arg Ala Arg Tyr Val 
        195                 200                 205             


Ser Ala Ser Ala Arg Ala Ile Leu Glu Glu Gln Gly Gly Leu Ala Trp 
    210                 215                 220                 


Leu Gln Gln Leu Arg Glu Ser Ser Tyr Glu Glu Ala His Lys Ala Leu 
225                 230                 235                 240 


Cys Ile Leu Pro Gly Val Gly Thr Lys Val Ala Asp Cys Ile Cys Leu 
                245                 250                 255     


Met Ala Leu Asp Lys Pro Gln Ala Val Pro Val Asp Val His Met Trp 
            260                 265                 270         


His Ile Ala Gln Arg Asp Tyr Ser Trp His Pro Thr Thr Ser Gln Ala 
        275                 280                 285             


Lys Gly Pro Ser Pro Gln Thr Asn Lys Glu Leu Gly Asn Phe Phe Arg 
    290                 295                 300                 


Ser Leu Trp Gly Pro Tyr Ala Gly Trp Ala Gln Ala Gly Leu Leu Gly 
305                 310                 315                 320 


Asn Ala Phe Asp Gly His Gln Leu Leu Arg Pro Leu Ile Phe Cys Gln 
                325                 330                 335     


Asp His Leu Arg Glu Gly Pro Pro Ile Gly Arg Gly Asp Ser Gln Gly 
            340                 345                 350         


Glu Glu Leu Glu Pro Gln Leu Pro Ser Ser Leu Ser Ser Ile Pro Tyr 
        355                 360                 365             


Gly Phe Cys Asp His Cys Trp Thr Lys Asp Val Asp Asp Pro Pro Leu 
    370                 375                 380                 


Val Thr His Pro Ser Pro Gly Ser Arg Asp Gly His Met Thr Gln Ala 
385                 390                 395                 400 


Trp Pro Val Lys Val Val Ser Pro Leu Ala Thr Val Ile Gly His Val 
                405                 410                 415     


Met Gln Ala Ser Leu Leu Ala Leu 
            420                 


<210>  9758
<211>  410
<212>  PRT
<213>  Homo Sapiens

<400>  9758

Met Pro Ala Arg Ala Leu Leu Pro Arg Arg Met Gly His Arg Thr Leu 
1               5                   10                  15      


Ala Ser Thr Pro Ala Leu Trp Ala Ser Ile Pro Cys Pro Arg Ser Glu 
            20                  25                  30          


Leu Arg Leu Asp Leu Val Leu Pro Ser Gly Gln Ser Phe Arg Trp Arg 
        35                  40                  45              


Glu Gln Ser Pro Ala His Trp Ser Gly Val Leu Ala Asp Gln Val Trp 
    50                  55                  60                  


Thr Leu Thr Gln Thr Glu Glu Gln Leu His Cys Thr Val Tyr Arg Gly 
65                  70                  75                  80  


Asp Lys Ser Gln Ala Ser Arg Pro Thr Pro Asp Glu Leu Glu Ala Val 
                85                  90                  95      


Arg Lys Tyr Phe Gln Leu Asp Val Thr Leu Ala Gln Leu Tyr His His 
            100                 105                 110         


Trp Gly Ser Val Asp Ser His Phe Gln Glu Val Ala Gln Lys Phe Gln 
        115                 120                 125             


Gly Val Arg Leu Leu Arg Gln Asp Pro Ile Glu Cys Leu Phe Ser Phe 
    130                 135                 140                 


Ile Cys Ser Ser Asn Asn Asn Ile Ala Arg Ile Thr Gly Met Val Glu 
145                 150                 155                 160 


Arg Leu Cys Gln Ala Phe Gly Pro Arg Leu Ile Gln Leu Asp Asp Val 
                165                 170                 175     


Thr Tyr His Gly Phe Pro Ser Leu Gln Ala Leu Ala Gly Pro Glu Val 
            180                 185                 190         


Glu Ala His Leu Arg Lys Leu Gly Leu Gly Tyr Arg Ala Arg Tyr Val 
        195                 200                 205             


Ser Ala Ser Ala Arg Ala Ile Leu Glu Glu Gln Gly Gly Leu Ala Trp 
    210                 215                 220                 


Leu Gln Gln Leu Arg Glu Ser Ser Tyr Glu Glu Ala His Lys Ala Leu 
225                 230                 235                 240 


Cys Ile Leu Pro Gly Val Gly Thr Lys Val Ala Asp Cys Ile Cys Leu 
                245                 250                 255     


Met Ala Leu Asp Lys Pro Gln Ala Val Pro Val Asp Val His Met Trp 
            260                 265                 270         


His Ile Ala Gln Arg Asp Tyr Ser Trp His Pro Thr Thr Ser Gln Ala 
        275                 280                 285             


Lys Gly Pro Ser Pro Gln Thr Asn Lys Glu Leu Gly Asn Phe Phe Arg 
    290                 295                 300                 


Ser Leu Trp Gly Pro Tyr Ala Gly Trp Ala Gln Ala Thr Pro Pro Ser 
305                 310                 315                 320 


Tyr Arg Cys Cys Ser Val Pro Thr Cys Ala Asn Pro Ala Met Leu Arg 
                325                 330                 335     


Ser His Gln Gln Ser Ala Glu Arg Val Pro Lys Gly Arg Lys Ala Arg 
            340                 345                 350         


Trp Gly Thr Leu Asp Lys Glu Ile Pro Gln Ala Pro Ser Pro Pro Phe 
        355                 360                 365             


Pro Thr Ser Leu Ser Pro Ser Pro Pro Ser Leu Met Leu Gly Arg Gly 
    370                 375                 380                 


Leu Pro Val Thr Thr Ser Lys Ala Arg His Pro Gln Ile Lys Gln Ser 
385                 390                 395                 400 


Val Cys Thr Thr Arg Trp Gly Gly Gly Tyr 
                405                 410 


<210>  9759
<211>  356
<212>  PRT
<213>  Homo Sapiens

<400>  9759

Met Pro Ala Arg Ala Leu Leu Pro Arg Arg Met Gly His Arg Thr Leu 
1               5                   10                  15      


Ala Ser Thr Pro Ala Leu Trp Ala Ser Ile Pro Cys Pro Arg Ser Glu 
            20                  25                  30          


Leu Arg Leu Asp Leu Val Leu Pro Ser Gly Gln Ser Phe Arg Trp Arg 
        35                  40                  45              


Glu Gln Ser Pro Ala His Trp Ser Gly Val Leu Ala Asp Gln Val Trp 
    50                  55                  60                  


Thr Leu Thr Gln Thr Glu Glu Gln Leu His Cys Thr Val Tyr Arg Gly 
65                  70                  75                  80  


Asp Lys Ser Gln Ala Ser Arg Pro Thr Pro Asp Glu Leu Glu Ala Val 
                85                  90                  95      


Arg Lys Tyr Phe Gln Leu Asp Val Thr Leu Ala Gln Leu Tyr His His 
            100                 105                 110         


Trp Gly Ser Val Asp Ser His Phe Gln Glu Val Ala Gln Lys Phe Gln 
        115                 120                 125             


Gly Val Arg Leu Leu Arg Gln Asp Pro Ile Glu Cys Leu Phe Ser Phe 
    130                 135                 140                 


Ile Cys Ser Ser Asn Asn Asn Ile Ala Arg Ile Thr Gly Met Val Glu 
145                 150                 155                 160 


Arg Leu Cys Gln Ala Phe Gly Pro Arg Leu Ile Gln Leu Asp Asp Val 
                165                 170                 175     


Thr Tyr His Gly Phe Pro Ser Leu Gln Ala Leu Ala Gly Pro Glu Val 
            180                 185                 190         


Glu Ala His Leu Arg Lys Leu Gly Leu Gly Tyr Arg Ala Arg Tyr Val 
        195                 200                 205             


Ser Ala Ser Ala Arg Ala Ile Leu Glu Glu Gln Gly Gly Leu Ala Trp 
    210                 215                 220                 


Leu Gln Gln Leu Arg Glu Ser Ser Tyr Glu Glu Ala His Lys Ala Leu 
225                 230                 235                 240 


Cys Ile Leu Pro Gly Val Gly Thr Lys Val Ala Asp Cys Ile Cys Leu 
                245                 250                 255     


Met Ala Leu Asp Lys Pro Gln Ala Val Pro Val Asp Val His Met Trp 
            260                 265                 270         


His Ile Ala Gln Arg Asp Tyr Ser Trp His Pro Thr Thr Ser Gln Ala 
        275                 280                 285             


Lys Gly Pro Ser Pro Gln Thr Asn Lys Glu Leu Gly Asn Phe Phe Arg 
    290                 295                 300                 


Ser Leu Trp Gly Pro Tyr Ala Gly Trp Ala Gln Ala Leu Cys Gln Val 
305                 310                 315                 320 


Ile Thr Thr Phe Met Thr Phe Leu Gly Pro His Arg Leu Asp Gln Met 
                325                 330                 335     


Pro Pro Glu Glu Leu Gln Thr Ser Ser Ser Arg Leu Gly Gly Pro Pro 
            340                 345                 350         


Trp Gln Cys Ile 
        355     


<210>  9760
<211>  324
<212>  PRT
<213>  Homo Sapiens

<400>  9760

Met Pro Ala Arg Ala Leu Leu Pro Arg Arg Met Gly His Arg Thr Leu 
1               5                   10                  15      


Ala Ser Thr Pro Ala Leu Trp Ala Ser Ile Pro Cys Pro Arg Ser Glu 
            20                  25                  30          


Leu Arg Leu Asp Leu Val Leu Pro Ser Gly Gln Ser Phe Arg Trp Arg 
        35                  40                  45              


Glu Gln Ser Pro Ala His Trp Ser Gly Val Leu Ala Asp Gln Val Trp 
    50                  55                  60                  


Thr Leu Thr Gln Thr Glu Glu Gln Leu His Cys Thr Val Tyr Arg Gly 
65                  70                  75                  80  


Asp Lys Ser Gln Ala Ser Arg Pro Thr Pro Asp Glu Leu Glu Ala Val 
                85                  90                  95      


Arg Lys Tyr Phe Gln Leu Asp Val Thr Leu Ala Gln Leu Tyr His His 
            100                 105                 110         


Trp Gly Ser Val Asp Ser His Phe Gln Glu Val Ala Gln Lys Phe Gln 
        115                 120                 125             


Gly Val Arg Leu Leu Arg Gln Asp Pro Ile Glu Cys Leu Phe Ser Phe 
    130                 135                 140                 


Ile Cys Ser Ser Asn Asn Asn Ile Ala Arg Ile Thr Gly Met Val Glu 
145                 150                 155                 160 


Arg Leu Cys Gln Ala Phe Gly Pro Arg Leu Ile Gln Leu Asp Asp Val 
                165                 170                 175     


Thr Tyr His Gly Phe Pro Ser Leu Gln Ala Leu Ala Gly Pro Glu Val 
            180                 185                 190         


Glu Ala His Leu Arg Lys Leu Gly Leu Gly Tyr Arg Ala Arg Tyr Val 
        195                 200                 205             


Ser Ala Ser Ala Arg Ala Ile Leu Glu Glu Gln Gly Gly Leu Ala Trp 
    210                 215                 220                 


Leu Gln Gln Leu Arg Glu Ser Ser Tyr Glu Glu Ala His Lys Ala Leu 
225                 230                 235                 240 


Cys Ile Leu Pro Gly Val Gly Thr Lys Val Ala Asp Cys Ile Cys Leu 
                245                 250                 255     


Met Ala Leu Asp Lys Pro Gln Ala Val Pro Val Asp Val His Met Trp 
            260                 265                 270         


His Ile Ala Gln Arg Asp Tyr Ser Trp His Pro Thr Thr Ser Gln Ala 
        275                 280                 285             


Lys Gly Pro Ser Pro Gln Thr Asn Lys Glu Leu Gly Asn Phe Phe Arg 
    290                 295                 300                 


Ser Leu Trp Gly Pro Tyr Ala Gly Trp Ala Gln Ala Val Ser Val Pro 
305                 310                 315                 320 


Arg Cys Pro Pro 
                


<210>  9761
<211>  345
<212>  PRT
<213>  Homo Sapiens

<400>  9761

Met Pro Ala Arg Ala Leu Leu Pro Arg Arg Met Gly His Arg Thr Leu 
1               5                   10                  15      


Ala Ser Thr Pro Ala Leu Trp Ala Ser Ile Pro Cys Pro Arg Ser Glu 
            20                  25                  30          


Leu Arg Leu Asp Leu Val Leu Pro Ser Gly Gln Ser Phe Arg Trp Arg 
        35                  40                  45              


Glu Gln Ser Pro Ala His Trp Ser Gly Val Leu Ala Asp Gln Val Trp 
    50                  55                  60                  


Thr Leu Thr Gln Thr Glu Glu Gln Leu His Cys Thr Val Tyr Arg Gly 
65                  70                  75                  80  


Asp Lys Ser Gln Ala Ser Arg Pro Thr Pro Asp Glu Leu Glu Ala Val 
                85                  90                  95      


Arg Lys Tyr Phe Gln Leu Asp Val Thr Leu Ala Gln Leu Tyr His His 
            100                 105                 110         


Trp Gly Ser Val Asp Ser His Phe Gln Glu Val Ala Gln Lys Phe Gln 
        115                 120                 125             


Gly Val Arg Leu Leu Arg Gln Asp Pro Ile Glu Cys Leu Phe Ser Phe 
    130                 135                 140                 


Ile Cys Ser Ser Asn Asn Asn Ile Ala Arg Ile Thr Gly Met Val Glu 
145                 150                 155                 160 


Arg Leu Cys Gln Ala Phe Gly Pro Arg Leu Ile Gln Leu Asp Asp Val 
                165                 170                 175     


Thr Tyr His Gly Phe Pro Ser Leu Gln Ala Leu Ala Gly Pro Glu Val 
            180                 185                 190         


Glu Ala His Leu Arg Lys Leu Gly Leu Gly Tyr Arg Ala Arg Tyr Val 
        195                 200                 205             


Ser Ala Ser Ala Arg Ala Ile Leu Glu Glu Gln Gly Gly Leu Ala Trp 
    210                 215                 220                 


Leu Gln Gln Leu Arg Glu Ser Ser Tyr Glu Glu Ala His Lys Ala Leu 
225                 230                 235                 240 


Cys Ile Leu Pro Gly Val Gly Thr Lys Val Ala Asp Cys Ile Cys Leu 
                245                 250                 255     


Met Ala Leu Asp Lys Pro Gln Ala Val Pro Val Asp Val His Met Trp 
            260                 265                 270         


His Ile Ala Gln Arg Asp Tyr Ser Trp His Pro Thr Thr Ser Gln Ala 
        275                 280                 285             


Lys Gly Pro Ser Pro Gln Thr Asn Lys Glu Leu Gly Asn Phe Phe Arg 
    290                 295                 300                 


Ser Leu Trp Gly Pro Tyr Ala Gly Trp Ala Gln Ala Val Leu Phe Ser 
305                 310                 315                 320 


Ala Asp Leu Arg Gln Ser Arg His Ala Gln Glu Pro Pro Ala Lys Arg 
                325                 330                 335     


Arg Lys Gly Ser Lys Gly Pro Glu Gly 
            340                 345 


<210>  9762
<211>  322
<212>  PRT
<213>  Homo Sapiens

<400>  9762

Met Pro Ala Arg Ala Leu Leu Pro Arg Arg Met Gly His Arg Thr Leu 
1               5                   10                  15      


Ala Ser Thr Pro Ala Leu Trp Ala Ser Ile Pro Cys Pro Arg Ser Glu 
            20                  25                  30          


Leu Arg Leu Asp Leu Val Leu Pro Ser Gly Gln Ser Phe Arg Trp Arg 
        35                  40                  45              


Glu Gln Ser Pro Ala His Trp Ser Gly Val Leu Ala Asp Gln Val Trp 
    50                  55                  60                  


Thr Leu Thr Gln Thr Glu Glu Gln Leu His Cys Thr Val Tyr Arg Gly 
65                  70                  75                  80  


Asp Lys Ser Gln Ala Ser Arg Pro Thr Pro Asp Glu Leu Glu Ala Val 
                85                  90                  95      


Arg Lys Tyr Phe Gln Leu Asp Val Thr Leu Ala Gln Leu Tyr His His 
            100                 105                 110         


Trp Gly Ser Val Asp Ser His Phe Gln Glu Val Ala Gln Lys Phe Gln 
        115                 120                 125             


Gly Val Arg Leu Leu Arg Gln Asp Pro Ile Glu Cys Leu Phe Ser Phe 
    130                 135                 140                 


Ile Cys Ser Ser Asn Asn Asn Ile Ala Arg Ile Thr Gly Met Val Glu 
145                 150                 155                 160 


Arg Leu Cys Gln Ala Phe Gly Pro Arg Leu Ile Gln Leu Asp Asp Val 
                165                 170                 175     


Thr Tyr His Gly Phe Pro Ser Leu Gln Ala Leu Ala Gly Pro Glu Val 
            180                 185                 190         


Glu Ala His Leu Arg Lys Leu Gly Leu Gly Tyr Arg Ala Arg Tyr Val 
        195                 200                 205             


Ser Ala Ser Ala Arg Ala Ile Leu Glu Glu Gln Gly Gly Leu Ala Trp 
    210                 215                 220                 


Leu Gln Gln Leu Arg Glu Ser Ser Tyr Glu Glu Ala His Lys Ala Leu 
225                 230                 235                 240 


Cys Ile Leu Pro Gly Val Gly Thr Lys Val Ala Asp Cys Ile Cys Leu 
                245                 250                 255     


Met Ala Leu Asp Lys Pro Gln Ala Val Pro Val Asp Val His Met Trp 
            260                 265                 270         


His Ile Ala Gln Arg Asp Tyr Ser Trp His Pro Thr Thr Ser Gln Ala 
        275                 280                 285             


Lys Gly Pro Ser Pro Gln Thr Asn Lys Glu Leu Gly Asn Phe Phe Arg 
    290                 295                 300                 


Ser Leu Trp Gly Pro Tyr Ala Gly Trp Ala Gln Ala Ala Gly Ser Asp 
305                 310                 315                 320 


Ala Ser 
        


<210>  9763
<211>  195
<212>  PRT
<213>  Homo Sapiens

<400>  9763

Met Pro Ala Arg Ala Leu Leu Pro Arg Arg Met Gly His Arg Thr Leu 
1               5                   10                  15      


Ala Ser Thr Pro Ala Leu Trp Ala Ser Ile Pro Cys Pro Arg Ser Glu 
            20                  25                  30          


Leu Arg Leu Asp Leu Val Leu Pro Ser Gly Gln Ser Phe Arg Trp Arg 
        35                  40                  45              


Glu Gln Ser Pro Ala His Trp Ser Gly Val Leu Ala Asp Gln Val Trp 
    50                  55                  60                  


Thr Leu Thr Gln Thr Glu Glu Gln Leu His Cys Thr Val Tyr Arg Gly 
65                  70                  75                  80  


Asp Lys Ser Gln Ala Ser Arg Pro Thr Pro Asp Glu Leu Glu Ala Val 
                85                  90                  95      


Arg Lys Tyr Phe Gln Leu Asp Val Thr Leu Ala Gln Leu Tyr His His 
            100                 105                 110         


Trp Gly Ser Val Asp Ser His Phe Gln Glu Val Ala Gln Lys Phe Gln 
        115                 120                 125             


Gly Val Arg Leu Leu Arg Gln Asp Pro Ile Glu Cys Leu Phe Ser Phe 
    130                 135                 140                 


Ile Cys Ser Ser Asn Asn Asn Ile Ala Arg Ile Thr Gly Met Val Glu 
145                 150                 155                 160 


Arg Leu Cys Gln Ala Phe Gly Pro Arg Leu Ile Gln Leu Asp Asp Val 
                165                 170                 175     


Thr Tyr His Gly Phe Pro Ser Leu Gln Ala Leu Ala Gly Pro Pro Trp 
            180                 185                 190         


Gln Cys Ile 
        195 


<210>  9764
<211>  168
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9764

Xaa Ala Ser Ile Pro Cys Pro Arg Ser Glu Leu Arg Leu Asp Leu Val 
1               5                   10                  15      


Leu Pro Ser Gly Gln Ser Phe Arg Trp Arg Glu Gln Ser Pro Ala His 
            20                  25                  30          


Trp Ser Gly Val Leu Ala Asp Gln Val Trp Thr Leu Thr Gln Thr Glu 
        35                  40                  45              


Glu Gln Leu His Cys Thr Val Tyr Arg Gly Asp Lys Ser Gln Ala Ser 
    50                  55                  60                  


Arg Pro Thr Pro Asp Glu Leu Glu Ala Val Arg Lys Tyr Phe Gln Leu 
65                  70                  75                  80  


Asp Val Thr Leu Ala Gln Leu Tyr His His Trp Gly Ser Val Asp Ser 
                85                  90                  95      


His Phe Gln Glu Val Ala Gln Lys Phe Gln Gly Val Arg Leu Leu Arg 
            100                 105                 110         


Gln Asp Pro Ile Glu Cys Leu Phe Ser Phe Ile Cys Ser Ser Asn Asn 
        115                 120                 125             


Asn Ile Ala Arg Ile Thr Gly Met Val Glu Arg Leu Cys Gln Ala Phe 
    130                 135                 140                 


Gly Pro Arg Leu Ile Gln Leu Asp Asp Val Thr Tyr His Gly Phe Pro 
145                 150                 155                 160 


Ser Leu Gln Ala Leu Ala Gly Gly 
                165             


<210>  9765
<211>  128
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9765

Xaa Glu Leu Glu Ala Val Arg Lys Tyr Phe Gln Leu Asp Val Thr Leu 
1               5                   10                  15      


Ala Gln Leu Tyr His His Trp Gly Ser Val Asp Ser His Phe Gln Glu 
            20                  25                  30          


Val Ala Gln Lys Phe Gln Gly Val Arg Leu Leu Arg Gln Asp Pro Ile 
        35                  40                  45              


Glu Cys Leu Phe Ser Phe Ile Cys Ser Ser Asn Asn Asn Ile Ala Arg 
    50                  55                  60                  


Ile Thr Gly Met Val Glu Arg Leu Cys Gln Ala Phe Gly Pro Arg Leu 
65                  70                  75                  80  


Ile Gln Leu Asp Asp Val Thr Tyr His Gly Phe Pro Ser Leu Gln Ala 
                85                  90                  95      


Leu Ala Gly Val Pro Val Pro Ala Glu Gly Leu Leu Thr Ser Ala Ser 
            100                 105                 110         


Ala Phe Gln Ser Pro Leu Arg Ser Arg Gln Pro Glu Ala Asp Arg Arg 
        115                 120                 125             


<210>  9766
<211>  132
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9766

Xaa Met Met Ser Pro Thr Met Ala Ser Pro Ala Cys Arg Pro Trp Leu 
1               5                   10                  15      


Val Ala Asp Cys Ile Cys Leu Met Ala Leu Asp Lys Pro Gln Ala Val 
            20                  25                  30          


Pro Val Asp Val His Met Trp His Ile Ala Gln Arg Asp Tyr Ser Trp 
        35                  40                  45              


His Pro Thr Thr Ser Gln Ala Lys Gly Pro Ser Pro Gln Thr Asn Lys 
    50                  55                  60                  


Glu Leu Gly Asn Phe Phe Arg Ser Leu Trp Gly Pro Tyr Ala Gly Trp 
65                  70                  75                  80  


Ala Gln Ala Thr Pro Pro Ser Tyr Arg Cys Cys Ser Val Pro Thr Cys 
                85                  90                  95      


Ala Asn Pro Ala Met Leu Arg Ser His Gln Gln Ser Ala Glu Arg Val 
            100                 105                 110         


Pro Lys Gly Arg Lys Ala Arg Trp Gly Thr Leu Asp Lys Glu Ile Pro 
        115                 120                 125             


Gln Ala Pro Ser 
    130         


<210>  9767
<211>  222
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9767

Xaa Pro Cys Gly Pro Pro Ser Arg Ala Leu Ala Leu Ser Cys Ala Trp 
1               5                   10                  15      


Thr Trp Phe Cys Leu Leu Asp Asn Leu Ser Gly Val Arg Leu Leu Arg 
            20                  25                  30          


Gln Asp Pro Ile Glu Cys Leu Phe Ser Phe Ile Cys Ser Ser Asn Asn 
        35                  40                  45              


Asn Ile Ala Arg Ile Thr Gly Met Val Glu Arg Leu Cys Gln Ala Phe 
    50                  55                  60                  


Gly Pro Arg Leu Ile Gln Leu Asp Asp Val Thr Tyr His Gly Phe Pro 
65                  70                  75                  80  


Ser Leu Gln Ala Leu Ala Gly Pro Glu Val Glu Ala His Leu Arg Lys 
                85                  90                  95      


Leu Gly Leu Gly Tyr Arg Ala Arg Tyr Val Ser Ala Ser Ala Arg Ala 
            100                 105                 110         


Ile Leu Glu Glu Gln Gly Gly Leu Ala Trp Leu Gln Gln Leu Arg Glu 
        115                 120                 125             


Ser Ser Tyr Glu Glu Ala His Lys Ala Leu Cys Ile Leu Pro Gly Val 
    130                 135                 140                 


Gly Thr Lys Val Ala Asp Cys Ile Cys Leu Met Ala Leu Asp Lys Pro 
145                 150                 155                 160 


Gln Ala Val Pro Val Asp Val His Met Trp His Ile Ala Gln Arg Asp 
                165                 170                 175     


Tyr Ser Trp His Pro Thr Thr Ser Gln Ala Lys Gly Pro Ser Pro Gln 
            180                 185                 190         


Thr Asn Lys Glu Leu Gly Asn Phe Phe Arg Ser Leu Trp Gly Pro Tyr 
        195                 200                 205             


Ala Gly Trp Ala Gln Ala Val Ser Val Pro Arg Cys Pro Pro 
    210                 215                 220         


<210>  9768
<211>  263
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9768

Xaa Val Arg Lys Tyr Phe Gln Leu Asp Val Thr Leu Ala Gln Leu Tyr 
1               5                   10                  15      


His His Trp Gly Ser Val Asp Ser His Phe Gln Glu Val Ala Gln Lys 
            20                  25                  30          


Phe Gln Gly Val Arg Leu Leu Arg Gln Asp Pro Ile Glu Cys Leu Phe 
        35                  40                  45              


Ser Phe Ile Cys Ser Ser Asn Asn Asn Ile Ala Arg Ile Thr Gly Met 
    50                  55                  60                  


Val Glu Arg Leu Cys Gln Ala Phe Gly Pro Arg Leu Ile Gln Leu Asp 
65                  70                  75                  80  


Asp Val Thr Tyr His Gly Phe Pro Ser Leu Gln Ala Leu Ala Gly Pro 
                85                  90                  95      


Glu Val Glu Ala His Leu Arg Lys Leu Gly Leu Gly Tyr Arg Ala Arg 
            100                 105                 110         


Tyr Val Ser Ala Ser Ala Arg Ala Ile Leu Glu Glu Gln Gly Gly Leu 
        115                 120                 125             


Ala Trp Leu Gln Gln Leu Arg Glu Ser Ser Tyr Glu Glu Ala His Lys 
    130                 135                 140                 


Ala Leu Cys Ile Leu Pro Gly Val Gly Thr Lys Gly Leu Leu Gly Asn 
145                 150                 155                 160 


Ala Phe Asp Gly His Gln Leu Leu Arg Pro Leu Ile Phe Cys Gln Asp 
                165                 170                 175     


His Leu Arg Glu Gly Pro Pro Ile Gly Arg Gly Asp Ser Gln Gly Glu 
            180                 185                 190         


Glu Leu Glu Pro Gln Leu Pro Ser Ser Leu Ser Ser Ile Pro Tyr Gly 
        195                 200                 205             


Phe Cys Asp His Cys Trp Thr Lys Asp Val Asp Asp Pro Pro Leu Val 
    210                 215                 220                 


Thr His Pro Ser Pro Gly Ser Arg Asp Gly His Met Thr Gln Ala Trp 
225                 230                 235                 240 


Pro Val Lys Val Val Ser Pro Leu Ala Thr Val Ile Gly His Val Met 
                245                 250                 255     


Gln Ala Ser Leu Leu Ala Leu 
            260             


<210>  9769
<211>  298
<212>  PRT
<213>  Homo Sapiens

<400>  9769

Met Lys Thr Leu Gln Ser Thr Leu Leu Leu Leu Leu Leu Val Pro Leu 
1               5                   10                  15      


Ile Lys Pro Ala Pro Pro Thr Gln Gln Asp Ser Arg Ile Ile Tyr Asp 
            20                  25                  30          


Tyr Gly Thr Asp Asn Phe Glu Glu Ser Ile Phe Ser Gln Asp Tyr Glu 
        35                  40                  45              


Asp Lys Tyr Leu Asp Gly Lys Asn Ile Lys Glu Lys Glu Thr Val Ile 
    50                  55                  60                  


Ile Pro Asn Glu Lys Ser Leu Gln Leu Gln Lys Asp Glu Ala Ile Thr 
65                  70                  75                  80  


Pro Leu Pro Pro Lys Lys Glu Asn Asp Glu Met Pro Thr Cys Leu Leu 
                85                  90                  95      


Cys Val Cys Leu Ser Gly Ser Val Tyr Cys Glu Glu Val Asp Ile Asp 
            100                 105                 110         


Ala Val Pro Pro Leu Pro Lys Glu Ser Ala Tyr Leu Tyr Ala Arg Phe 
        115                 120                 125             


Asn Lys Ile Lys Lys Leu Thr Ala Lys Asp Phe Ala Asp Ile Pro Asn 
    130                 135                 140                 


Leu Arg Arg Leu Asp Phe Thr Gly Asn Leu Ile Glu Asp Ile Glu Asp 
145                 150                 155                 160 


Gly Thr Phe Ser Lys Leu Ser Leu Leu Glu Glu Leu Ser Leu Ala Glu 
                165                 170                 175     


Asn Gln Leu Leu Lys Leu Pro Val Leu Pro Pro Lys Leu Thr Leu Phe 
            180                 185                 190         


Asn Ala Lys Tyr Asn Lys Ile Lys Ser Arg Gly Ile Lys Ala Asn Ala 
        195                 200                 205             


Phe Lys Lys Leu Asn Asn Leu Thr Phe Leu Tyr Leu Asp His Asn Ala 
    210                 215                 220                 


Leu Glu Ser Val Pro Leu Asn Leu Pro Glu Ser Leu Arg Val Ile His 
225                 230                 235                 240 


Leu Gln Phe Asn Asn Ile Ala Ser Ile Thr Asp Asp Thr Phe Cys Lys 
                245                 250                 255     


Ala Asn Asp Thr Ser Tyr Ile Arg Asp Arg Ile Glu Glu Ile Arg Leu 
            260                 265                 270         


Glu Gly Asn Pro Ile Val Leu Gly Lys His Pro Asn Ser Phe Ile Cys 
        275                 280                 285             


Leu Lys Arg Leu Pro Ile Gly Ser Tyr Phe 
    290                 295             


<210>  9770
<211>  298
<212>  PRT
<213>  Homo Sapiens

<400>  9770

Met Lys Thr Leu Gln Ser Thr Leu Leu Leu Leu Leu Leu Val Pro Leu 
1               5                   10                  15      


Ile Lys Pro Ala Pro Pro Thr Gln Gln Asp Ser Arg Ile Ile Tyr Asp 
            20                  25                  30          


Tyr Gly Thr Asp Asn Phe Glu Glu Ser Ile Phe Ser Gln Asp Tyr Glu 
        35                  40                  45              


Asp Lys Tyr Leu Asp Gly Lys Asn Ile Lys Glu Lys Glu Thr Val Ile 
    50                  55                  60                  


Ile Pro Asn Glu Lys Ser Leu Gln Leu Gln Lys Asp Glu Ala Ile Thr 
65                  70                  75                  80  


Pro Leu Pro Pro Lys Lys Glu Asn Asp Glu Met Pro Thr Cys Leu Leu 
                85                  90                  95      


Cys Val Cys Leu Ser Gly Ser Val Tyr Cys Glu Glu Val Asp Ile Asp 
            100                 105                 110         


Ala Val Pro Pro Leu Pro Lys Glu Ser Ala Tyr Leu Tyr Ala Arg Phe 
        115                 120                 125             


Asn Lys Ile Lys Lys Leu Thr Ala Lys Asp Phe Ala Asp Ile Pro Asn 
    130                 135                 140                 


Leu Arg Arg Leu Asp Phe Thr Gly Asn Leu Ile Glu Asp Ile Glu Asp 
145                 150                 155                 160 


Gly Thr Phe Ser Lys Leu Ser Leu Leu Glu Glu Leu Ser Leu Ala Glu 
                165                 170                 175     


Asn Gln Leu Leu Lys Leu Pro Val Leu Pro Pro Lys Leu Thr Leu Phe 
            180                 185                 190         


Asn Ala Lys Tyr Asn Lys Ile Lys Ser Arg Gly Ile Lys Ala Asn Ala 
        195                 200                 205             


Phe Lys Lys Leu Asn Asn Leu Thr Phe Leu Tyr Leu Asp His Asn Ala 
    210                 215                 220                 


Leu Glu Ser Val Pro Leu Asn Leu Pro Glu Ser Leu Arg Val Ile His 
225                 230                 235                 240 


Leu Gln Phe Asn Asn Ile Ala Ser Ile Thr Asp Asp Thr Phe Cys Lys 
                245                 250                 255     


Ala Asn Asp Thr Ser Tyr Ile Arg Asp Arg Ile Glu Glu Ile Arg Leu 
            260                 265                 270         


Glu Gly Asn Pro Ile Val Leu Gly Lys His Pro Asn Ser Phe Ile Cys 
        275                 280                 285             


Leu Lys Arg Leu Pro Ile Gly Ser Tyr Phe 
    290                 295             


<210>  9771
<211>  268
<212>  PRT
<213>  Homo Sapiens

<400>  9771

Met Leu Ala Lys Ile Ser Thr Thr Trp Lys Leu Phe Leu Lys Leu Leu 
1               5                   10                  15      


Gly Pro Glu Ile Leu Leu Ser Ser Leu Lys Ser Arg His Ser Phe Ser 
            20                  25                  30          


His Ser Pro Ser His Leu Gly Leu Met His Arg His Glu His Leu Leu 
        35                  40                  45              


Arg Lys Thr Thr Lys Asn Phe Lys Thr Ala Thr Thr Thr Leu Gln Ser 
    50                  55                  60                  


Thr Leu Leu Leu Leu Leu Leu Val Pro Leu Ile Lys Pro Ala Pro Pro 
65                  70                  75                  80  


Thr Gln Gln Asp Ser Arg Ile Ile Tyr Asp Tyr Gly Thr Asp Asn Phe 
                85                  90                  95      


Glu Glu Ser Ile Phe Ser Gln Asp Tyr Glu Asp Lys Tyr Leu Asp Gly 
            100                 105                 110         


Lys Asn Ile Lys Glu Lys Glu Thr Val Ile Ile Pro Asn Glu Lys Ser 
        115                 120                 125             


Leu Gln Leu Gln Lys Asp Glu Ala Ile Thr Pro Leu Pro Pro Lys Lys 
    130                 135                 140                 


Glu Asn Asp Glu Met Pro Thr Cys Leu Leu Cys Val Cys Leu Ser Gly 
145                 150                 155                 160 


Ser Val Tyr Cys Glu Glu Val Asp Ile Asp Ala Val Pro Pro Leu Pro 
                165                 170                 175     


Lys Glu Ser Ala Tyr Leu Tyr Ala Arg Phe Asn Lys Ile Lys Lys Leu 
            180                 185                 190         


Thr Ala Lys Asp Phe Ala Asp Ile Pro Asn Leu Arg Arg Leu Asp Phe 
        195                 200                 205             


Thr Gly Asn Leu Ile Glu Asp Ile Glu Asp Gly Thr Phe Ser Lys Leu 
    210                 215                 220                 


Ser Leu Leu Glu Glu Leu Ser Leu Ala Glu Asn Gln Leu Leu Lys Leu 
225                 230                 235                 240 


Pro Val Leu Pro Pro Lys Leu Thr Leu Phe Asn Ala Lys Tyr Asn Lys 
                245                 250                 255     


Ile Lys Ser Arg Gly Ile Lys Ala Asn Ala Phe Lys 
            260                 265             


<210>  9772
<211>  545
<212>  PRT
<213>  Homo Sapiens

<400>  9772

Met Pro Pro Phe Leu Leu Leu Thr Cys Leu Phe Ile Thr Gly Thr Ser 
1               5                   10                  15      


Val Ser Pro Val Ala Leu Asp Pro Cys Ser Ala Tyr Ile Ser Leu Asn 
            20                  25                  30          


Glu Pro Trp Arg Asn Thr Asp His Gln Leu Asp Glu Ser Gln Gly Pro 
        35                  40                  45              


Pro Leu Cys Asp Asn His Val Asn Gly Glu Trp Tyr His Phe Thr Gly 
    50                  55                  60                  


Met Ala Gly Asp Ala Met Pro Thr Phe Cys Ile Pro Glu Asn His Cys 
65                  70                  75                  80  


Gly Thr His Ala Pro Val Trp Leu Asn Gly Ser His Pro Leu Glu Gly 
                85                  90                  95      


Asp Gly Ile Val Gln Arg Gln Ala Cys Ala Ser Phe Asn Gly Asn Cys 
            100                 105                 110         


Cys Leu Trp Asn Thr Thr Val Glu Val Lys Ala Cys Pro Gly Gly Tyr 
        115                 120                 125             


Tyr Val Tyr Arg Leu Thr Lys Pro Ser Val Cys Phe His Val Tyr Cys 
    130                 135                 140                 


Gly His Phe Tyr Asp Ile Cys Asp Glu Asp Cys His Gly Ser Cys Ser 
145                 150                 155                 160 


Asp Thr Ser Glu Cys Thr Cys Ala Pro Gly Thr Val Leu Gly Pro Asp 
                165                 170                 175     


Arg Gln Thr Cys Phe Asp Glu Asn Glu Cys Glu Gln Asn Asn Gly Gly 
            180                 185                 190         


Cys Ser Glu Ile Cys Val Asn Leu Lys Asn Ser Tyr Arg Cys Glu Cys 
        195                 200                 205             


Gly Val Gly Arg Val Leu Arg Ser Asp Gly Lys Thr Cys Glu Asp Val 
    210                 215                 220                 


Glu Gly Cys His Asn Asn Asn Gly Gly Cys Ser His Ser Cys Leu Gly 
225                 230                 235                 240 


Ser Glu Lys Gly Tyr Gln Cys Glu Cys Pro Arg Gly Leu Val Leu Ser 
                245                 250                 255     


Glu Asp Asn His Thr Cys Gln Val Pro Val Leu Cys Lys Ser Asn Ala 
            260                 265                 270         


Ile Glu Val Asn Ile Pro Arg Glu Leu Val Gly Gly Leu Glu Leu Phe 
        275                 280                 285             


Leu Thr Asn Thr Ser Cys Arg Gly Val Ser Asn Gly Thr His Val Asn 
    290                 295                 300                 


Ile Leu Phe Ser Leu Lys Thr Cys Gly Thr Val Val Asp Val Val Asn 
305                 310                 315                 320 


Asp Lys Ile Val Ala Ser Asn Leu Val Thr Gly Leu Pro Lys Gln Thr 
                325                 330                 335     


Pro Gly Ser Ser Gly Asp Phe Ile Ile Arg Thr Ser Lys Leu Leu Ile 
            340                 345                 350         


Pro Val Thr Cys Glu Phe Pro Arg Leu Tyr Thr Ile Ser Glu Gly Tyr 
        355                 360                 365             


Val Pro Asn Leu Arg Asn Ser Pro Leu Glu Ile Met Ser Arg Asn His 
    370                 375                 380                 


Gly Ile Phe Pro Phe Thr Leu Glu Ile Phe Lys Asp Asn Glu Phe Glu 
385                 390                 395                 400 


Glu Pro Tyr Arg Glu Ala Leu Pro Thr Leu Lys Leu Arg Asp Ser Leu 
                405                 410                 415     


Tyr Phe Gly Ile Glu Pro Val Val His Val Ser Gly Leu Glu Ser Leu 
            420                 425                 430         


Val Glu Ser Cys Phe Ala Thr Pro Thr Ser Lys Ile Asp Glu Val Leu 
        435                 440                 445             


Lys Tyr Tyr Leu Ile Arg Asp Gly Cys Val Ser Asp Asp Ser Val Lys 
    450                 455                 460                 


Gln Tyr Thr Ser Arg Asp His Leu Ala Lys His Phe Gln Val Pro Val 
465                 470                 475                 480 


Phe Lys Phe Val Gly Lys Asp His Lys Glu Val Phe Leu His Cys Arg 
                485                 490                 495     


Val Leu Val Cys Gly Val Leu Asp Glu Arg Ser Arg Cys Ala Gln Gly 
            500                 505                 510         


Cys His Arg Arg Met Arg Arg Gly Ala Gly Gly Glu Asp Ser Ala Gly 
        515                 520                 525             


Leu Gln Gly Gln Thr Leu Thr Gly Gly Pro Ile Arg Ile Asp Trp Glu 
    530                 535                 540                 


Asp 
545 


<210>  9773
<211>  321
<212>  PRT
<213>  Homo Sapiens

<400>  9773

Met Pro Pro Phe Leu Leu Leu Thr Cys Leu Phe Ile Thr Gly Thr Ser 
1               5                   10                  15      


Val Ser Pro Val Ala Leu Asp Pro Cys Ser Ala Tyr Ile Ser Leu Asn 
            20                  25                  30          


Glu Pro Trp Arg Asn Thr Asp His Gln Leu Asp Glu Ser Gln Gly Pro 
        35                  40                  45              


Pro Leu Cys Asp Asn His Val Asn Gly Glu Trp Tyr His Phe Thr Gly 
    50                  55                  60                  


Met Ala Gly Asp Ala Met Pro Thr Phe Cys Ile Pro Glu Asn His Cys 
65                  70                  75                  80  


Gly Thr His Ala Pro Val Trp Leu Asn Gly Ser His Pro Leu Glu Gly 
                85                  90                  95      


Asp Gly Ile Val Gln Arg Gln Ala Cys Ala Ser Phe Asn Gly Asn Cys 
            100                 105                 110         


Cys Leu Trp Asn Thr Thr Val Glu Val Lys Ala Cys Pro Gly Gly Tyr 
        115                 120                 125             


Tyr Val Tyr Arg Leu Thr Lys Pro Ser Val Cys Phe His Val Tyr Cys 
    130                 135                 140                 


Gly His Phe Tyr Asp Ile Cys Asp Glu Asp Cys His Gly Ser Cys Ser 
145                 150                 155                 160 


Asp Thr Ser Glu Cys Thr Cys Ala Pro Gly Thr Val Leu Gly Pro Asp 
                165                 170                 175     


Arg Gln Thr Cys Phe Asp Glu Asn Glu Cys Glu Gln Asn Asn Gly Gly 
            180                 185                 190         


Cys Ser Glu Ile Cys Val Asn Leu Lys Asn Ser Tyr Arg Cys Glu Cys 
        195                 200                 205             


Gly Val Gly Arg Val Leu Arg Ser Asp Gly Lys Thr Cys Glu Asp Val 
    210                 215                 220                 


Glu Gly Cys His Asn Asn Asn Gly Gly Cys Ser His Ser Cys Leu Gly 
225                 230                 235                 240 


Ser Glu Lys Gly Tyr Gln Cys Glu Cys Pro Arg Gly Leu Val Leu Ser 
                245                 250                 255     


Glu Asp Asn His Thr Cys Gln Val Pro Val Leu Cys Lys Ser Asn Ala 
            260                 265                 270         


Ile Glu Val Asn Ile Pro Arg Glu Leu Val Gly Gly Leu Glu Leu Phe 
        275                 280                 285             


Leu Thr Asn Thr Ser Cys Arg Gly Val Ser Asn Gly Thr His Val Asn 
    290                 295                 300                 


Ile Leu Phe Ser Leu Lys Thr Cys Gly Thr Val Val Asp Leu Cys Phe 
305                 310                 315                 320 


Arg 
    


<210>  9774
<211>  129
<212>  PRT
<213>  Homo Sapiens

<400>  9774

Met Cys Ser Arg Asp Ala Arg Thr Lys Gln Leu Arg Gln Leu Leu Glu 
1               5                   10                  15      


Lys Val Gln Asn Met Ser Gln Ser Ile Glu Val Leu Asp Arg Arg Thr 
            20                  25                  30          


Gln Arg Asp Leu Gln Tyr Val Glu Lys Met Glu Asn Gln Met Lys Gly 
        35                  40                  45              


Leu Glu Ser Lys Phe Lys Gln Val Glu Glu Ser His Lys Gln His Leu 
    50                  55                  60                  


Ala Arg Gln Phe Lys Ala Ile Lys Ala Lys Met Asp Glu Leu Arg Pro 
65                  70                  75                  80  


Leu Ile Pro Val Leu Glu Glu Tyr Lys Ala Asp Ala Lys Leu Val Leu 
                85                  90                  95      


Gln Phe Lys Glu Glu Val Gln Asn Leu Thr Ser Val Leu Asn Glu Leu 
            100                 105                 110         


Gln Glu Glu Ile Gly Ala Tyr Asp Tyr Asp Glu Leu Gln Ser Arg Val 
        115                 120                 125             


Ser 
    


<210>  9775
<211>  163
<212>  PRT
<213>  Homo Sapiens

<400>  9775

Met Glu Gly Pro Gly Gly Ser Gly Phe His Leu Arg Leu Glu Ala Phe 
1               5                   10                  15      


Cys Lys Cys Lys Ser Pro Ile Asn Val Phe Asp Pro Val Arg Pro Ala 
            20                  25                  30          


Leu Gln Val Gly Leu Thr Arg Val Leu Pro Thr Asn Pro Glu Glu Ser 
        35                  40                  45              


Trp Gln Val Tyr Ser Ser Ala Gln Asp Ser Glu Gly Arg Cys Ile Cys 
    50                  55                  60                  


Thr Val Val Ala Pro Gln Gln Thr Met Cys Ser Arg Asp Ala Arg Thr 
65                  70                  75                  80  


Lys Gln Leu Arg Gln Leu Leu Glu Lys Val Gln Asn Met Ser Gln Ser 
                85                  90                  95      


Ile Glu Val Leu Asp Arg Arg Thr Gln Arg Asp Leu Gln Tyr Val Glu 
            100                 105                 110         


Lys Met Glu Asn Gln Met Lys Gly Leu Glu Ser Lys Phe Lys Gln Val 
        115                 120                 125             


Glu Glu Ser His Lys Gln His Leu Ala Arg Gln Phe Lys Ala Ile Lys 
    130                 135                 140                 


Ala Lys Met Asp Glu Leu Arg Pro Leu Ile Pro Val Leu Glu Glu Tyr 
145                 150                 155                 160 


Lys Ala Asp 
            


<210>  9776
<211>  458
<212>  PRT
<213>  Homo Sapiens

<400>  9776

Met Gly Glu Ala Pro Gly Arg Glu Gly Arg Gly Pro Cys Pro Gln Leu 
1               5                   10                  15      


Glu Ser Pro Arg Arg Arg Arg Val Leu Pro Thr Asn Pro Glu Glu Ser 
            20                  25                  30          


Trp Gln Val Tyr Ser Ser Ala Gln Asp Ser Glu Gly Arg Cys Ile Cys 
        35                  40                  45              


Thr Val Val Ala Pro Gln Gln Thr Met Cys Ser Arg Asp Ala Arg Thr 
    50                  55                  60                  


Lys Gln Leu Arg Gln Leu Leu Glu Lys Val Gln Asn Met Ser Gln Ser 
65                  70                  75                  80  


Ile Glu Val Leu Asp Arg Arg Thr Gln Arg Asp Leu Gln Tyr Val Glu 
                85                  90                  95      


Lys Met Glu Asn Gln Met Lys Gly Leu Glu Ser Lys Phe Lys Gln Val 
            100                 105                 110         


Glu Glu Ser His Lys Gln His Leu Ala Arg Gln Phe Lys Ala Ile Lys 
        115                 120                 125             


Ala Lys Met Asp Glu Leu Arg Pro Leu Ile Pro Val Leu Glu Glu Tyr 
    130                 135                 140                 


Lys Ala Asp Ala Lys Leu Val Leu Gln Phe Lys Glu Glu Val Gln Asn 
145                 150                 155                 160 


Leu Thr Ser Val Leu Asn Glu Leu Gln Glu Glu Ile Gly Ala Tyr Asp 
                165                 170                 175     


Tyr Asp Glu Leu Gln Ser Arg Val Ser Asn Leu Glu Glu Arg Leu Arg 
            180                 185                 190         


Ala Cys Met Gln Lys Leu Ala Cys Gly Lys Leu Thr Gly Ile Ser Asp 
        195                 200                 205             


Pro Val Thr Val Lys Thr Ser Gly Ser Arg Phe Gly Ser Trp Met Thr 
    210                 215                 220                 


Asp Pro Leu Ala Pro Glu Gly Asp Asn Arg Val Trp Tyr Met Asp Gly 
225                 230                 235                 240 


Tyr His Asn Asn Arg Phe Val Arg Glu Tyr Lys Ser Met Val Asp Phe 
                245                 250                 255     


Met Asn Thr Asp Asn Phe Thr Ser His Arg Leu Pro His Pro Trp Ser 
            260                 265                 270         


Gly Thr Gly Gln Val Val Tyr Asn Gly Ser Ile Tyr Phe Asn Lys Phe 
        275                 280                 285             


Gln Ser His Ile Ile Ile Arg Phe Asp Leu Lys Thr Glu Thr Ile Leu 
    290                 295                 300                 


Lys Thr Arg Ser Leu Asp Tyr Ala Gly Tyr Asn Asn Met Tyr His Tyr 
305                 310                 315                 320 


Ala Trp Gly Gly His Ser Asp Ile Asp Leu Met Val Asp Glu Ser Gly 
                325                 330                 335     


Leu Trp Ala Val Tyr Ala Thr Asn Gln Asn Ala Gly Asn Ile Val Val 
            340                 345                 350         


Ser Arg Leu Asp Pro Val Ser Leu Gln Thr Leu Gln Thr Trp Asn Thr 
        355                 360                 365             


Ser Tyr Pro Lys Arg Ser Ala Gly Glu Ala Phe Ile Ile Cys Gly Thr 
    370                 375                 380                 


Leu Tyr Val Thr Asn Gly Tyr Ser Gly Gly Thr Lys Val His Tyr Ala 
385                 390                 395                 400 


Tyr Gln Thr Asn Ala Ser Thr Tyr Glu Tyr Ile Asp Ile Pro Phe Gln 
                405                 410                 415     


Asn Lys Tyr Ser His Ile Ser Met Leu Asp Tyr Asn Pro Lys Asp Arg 
            420                 425                 430         


Ala Leu Tyr Ala Trp Asn Asn Gly His Gln Ile Leu Tyr Asn Val Thr 
        435                 440                 445             


Leu Phe His Val Ile Arg Ser Asp Glu Leu 
    450                 455             


<210>  9777
<211>  129
<212>  PRT
<213>  Homo Sapiens

<400>  9777

Met Pro Gly Arg Trp Arg Trp Gln Arg Asp Met His Pro Ala Arg Lys 
1               5                   10                  15      


Leu Leu Ser Leu Leu Phe Leu Ile Leu Met Gly Thr Glu Leu Thr Gln 
            20                  25                  30          


Asp Ser Ala Ala Pro Asp Ser Leu Leu Arg Ser Ser Lys Gly Ser Thr 
        35                  40                  45              


Arg Gly Ser Leu Ala Ala Ile Val Ile Trp Arg Gly Lys Ser Glu Ser 
    50                  55                  60                  


Arg Ile Ala Lys Thr Pro Gly Ile Phe Arg Gly Gly Gly Thr Leu Val 
65                  70                  75                  80  


Leu Pro Pro Thr His Thr Pro Glu Trp Leu Ile Leu Pro Leu Gly Ile 
                85                  90                  95      


Thr Leu Pro Leu Gly Ala Pro Glu Thr Gly Gly Gly Asp Cys Ala Ala 
            100                 105                 110         


Glu Thr Trp Lys Gly Ser Gln Arg Ala Gly Gln Leu Cys Ala Leu Leu 
        115                 120                 125             


Ala 
    


<210>  9778
<211>  167
<212>  PRT
<213>  Homo Sapiens

<400>  9778

Met Pro Gly Arg Trp Arg Trp Gln Arg Asp Met His Pro Ala Arg Lys 
1               5                   10                  15      


Leu Leu Ser Leu Leu Phe Leu Ile Leu Met Gly Thr Glu Leu Thr Gln 
            20                  25                  30          


Asn Lys Arg Glu Asn Lys Ala Glu Lys Met Gly Gly Pro Glu Ser Glu 
        35                  40                  45              


Arg Lys Thr Thr Gly Glu Lys Thr Leu Asn Glu Leu Pro Leu Phe Cys 
    50                  55                  60                  


Leu Glu Ala His Ala Gly Ser Leu Ala Leu Pro Arg Met Cys Ser Pro 
65                  70                  75                  80  


Asn Pro Asn Pro Ala Val Gly Leu Cys Arg Pro Ala Tyr Pro Gln Ser 
                85                  90                  95      


Pro Ser Pro Gly Ala Ala Gln Thr Ile Ser Gln Ser Leu Leu Glu Arg 
            100                 105                 110         


Phe Cys Met Ala Ser Arg Arg Gly Phe Leu Gly Pro Arg Lys Ala Trp 
        115                 120                 125             


Trp Arg Val Val Val Val His Cys Cys Trp Thr Asp Ala Phe Ile His 
    130                 135                 140                 


Val His Thr His Thr His Thr Cys Thr His Arg Gly Ala Asp Thr Cys 
145                 150                 155                 160 


Arg Glu Glu Pro Thr Arg Ser 
                165         


<210>  9779
<211>  467
<212>  PRT
<213>  Homo Sapiens

<400>  9779

Met Pro Gly Arg Trp Arg Trp Gln Arg Asp Met His Pro Ala Arg Lys 
1               5                   10                  15      


Leu Leu Ser Leu Leu Phe Leu Ile Leu Met Gly Thr Glu Leu Thr Gln 
            20                  25                  30          


Val Leu Pro Thr Asn Pro Glu Glu Ser Trp Gln Val Tyr Ser Ser Ala 
        35                  40                  45              


Gln Asp Ser Glu Gly Arg Cys Ile Cys Thr Val Val Ala Pro Gln Gln 
    50                  55                  60                  


Thr Met Cys Ser Arg Asp Ala Arg Thr Lys Gln Leu Arg Gln Leu Leu 
65                  70                  75                  80  


Glu Lys Val Gln Asn Met Ser Gln Ser Ile Glu Val Leu Asp Arg Arg 
                85                  90                  95      


Thr Gln Arg Asp Leu Gln Tyr Val Glu Lys Met Glu Asn Gln Met Lys 
            100                 105                 110         


Gly Leu Glu Ser Lys Phe Lys Gln Val Glu Glu Ser His Lys Gln His 
        115                 120                 125             


Leu Ala Arg Gln Phe Lys Ala Ile Lys Ala Lys Met Asp Glu Leu Arg 
    130                 135                 140                 


Pro Leu Ile Pro Val Leu Glu Glu Tyr Lys Ala Asp Ala Lys Leu Val 
145                 150                 155                 160 


Leu Gln Phe Lys Glu Glu Val Gln Asn Leu Thr Ser Val Leu Asn Glu 
                165                 170                 175     


Leu Gln Glu Glu Ile Gly Ala Tyr Asp Tyr Asp Glu Leu Gln Ser Arg 
            180                 185                 190         


Val Ser Asn Leu Glu Glu Arg Leu Arg Ala Cys Met Gln Lys Leu Ala 
        195                 200                 205             


Cys Gly Lys Leu Thr Gly Ile Ser Asp Pro Val Thr Val Lys Thr Ser 
    210                 215                 220                 


Gly Ser Arg Phe Gly Ser Trp Met Thr Asp Pro Leu Ala Pro Glu Gly 
225                 230                 235                 240 


Asp Asn Arg Val Trp Tyr Met Asp Gly Tyr His Asn Asn Arg Phe Val 
                245                 250                 255     


Arg Glu Tyr Lys Ser Met Val Asp Phe Met Asn Thr Asp Asn Phe Thr 
            260                 265                 270         


Ser His Arg Leu Pro His Pro Trp Ser Gly Thr Gly Gln Val Val Tyr 
        275                 280                 285             


Asn Gly Ser Ile Tyr Phe Asn Lys Phe Gln Ser His Ile Ile Ile Arg 
    290                 295                 300                 


Phe Asp Leu Lys Thr Glu Thr Ile Leu Lys Thr Arg Ser Leu Asp Tyr 
305                 310                 315                 320 


Ala Gly Tyr Asn Asn Met Tyr His Tyr Ala Trp Gly Gly His Ser Asp 
                325                 330                 335     


Ile Asp Leu Met Val Asp Glu Ser Gly Leu Trp Ala Val Tyr Ala Thr 
            340                 345                 350         


Asn Gln Asn Ala Gly Asn Ile Val Val Ser Arg Leu Asp Pro Val Ser 
        355                 360                 365             


Leu Gln Thr Leu Gln Thr Trp Asn Thr Ser Tyr Pro Lys Arg Ser Ala 
    370                 375                 380                 


Gly Glu Ala Phe Ile Ile Cys Gly Thr Leu Tyr Val Thr Asn Gly Tyr 
385                 390                 395                 400 


Ser Gly Gly Thr Lys Val His Tyr Ala Tyr Gln Thr Asn Ala Ser Thr 
                405                 410                 415     


Tyr Glu Tyr Ile Asp Ile Pro Phe Gln Asn Lys Tyr Ser His Ile Ser 
            420                 425                 430         


Met Leu Asp Tyr Asn Pro Lys Asp Arg Ala Leu Tyr Ala Trp Asn Asn 
        435                 440                 445             


Gly His Gln Ile Leu Tyr Asn Val Thr Leu Phe His Val Ile Arg Ser 
    450                 455                 460                 


Asp Glu Leu 
465         


<210>  9780
<211>  135
<212>  PRT
<213>  Homo Sapiens

<400>  9780

Met Pro Gly Arg Trp Arg Trp Gln Arg Asp Met His Pro Ala Arg Lys 
1               5                   10                  15      


Leu Leu Ser Leu Leu Phe Leu Ile Leu Met Gly Thr Glu Leu Thr Gln 
            20                  25                  30          


Val Leu Pro Thr Asn Pro Glu Glu Ser Trp Gln Val Tyr Ser Ser Ala 
        35                  40                  45              


Gln Asp Ser Glu Gly Arg Cys Ile Cys Thr Val Val Ala Pro Gln Gln 
    50                  55                  60                  


Thr Met Cys Ser Arg Asp Ala Arg Thr Lys Gln Leu Arg Gln Leu Leu 
65                  70                  75                  80  


Glu Lys Val Gln Asn Met Ser Gln Ser Ile Glu Val Leu Asp Arg Arg 
                85                  90                  95      


Thr Gln Arg Asp Leu Gln Tyr Val Glu Lys Met Glu Asn Gln Met Lys 
            100                 105                 110         


Gly Leu Glu Ser Lys Phe Lys Gln Val Glu Glu Ser His Lys Gln His 
        115                 120                 125             


Leu Ala Arg Gln Phe Lys Gly 
    130                 135 


<210>  9781
<211>  208
<212>  PRT
<213>  Homo Sapiens

<400>  9781

Met Ser Gln Ser Ile Glu Val Leu Asp Arg Arg Thr Gln Arg Asp Leu 
1               5                   10                  15      


Gln Tyr Val Glu Lys Met Glu Asn Gln Met Lys Gly Leu Glu Ser Lys 
            20                  25                  30          


Phe Lys Gln Val Glu Glu Ser His Lys Gln His Leu Ala Arg Gln Phe 
        35                  40                  45              


Lys Ala Ile Lys Ala Lys Met Asp Glu Leu Arg Pro Leu Ile Pro Val 
    50                  55                  60                  


Leu Glu Glu Tyr Lys Ala Asp Ala Lys Leu Val Leu Gln Phe Lys Glu 
65                  70                  75                  80  


Glu Val Gln Asn Leu Thr Ser Val Leu Asn Glu Leu Gln Glu Glu Ile 
                85                  90                  95      


Gly Ala Tyr Asp Tyr Asp Glu Leu Gln Ser Arg Val Ser Asn Leu Glu 
            100                 105                 110         


Glu Arg Leu Arg Ala Cys Met Gln Lys Leu Ala Cys Gly Lys Leu Thr 
        115                 120                 125             


Gly Ile Ser Asp Pro Val Thr Val Lys Thr Ser Gly Ser Arg Phe Gly 
    130                 135                 140                 


Ser Trp Met Thr Asp Pro Leu Ala Pro Glu Gly Asp Asn Arg Val Trp 
145                 150                 155                 160 


Tyr Met Asp Gly Tyr His Asn Asn Arg Phe Val Arg Glu Tyr Lys Ser 
                165                 170                 175     


Met Val Asp Phe Met Asn Thr Asp Asn Phe Thr Ser His Arg Leu Pro 
            180                 185                 190         


His Pro Trp Ser Gly Thr Gly Gln Val Val Tyr Asn Gly Ser Ile Tyr 
        195                 200                 205             


<210>  9782
<211>  485
<212>  PRT
<213>  Homo Sapiens

<400>  9782

Met Ser Val Pro Leu Leu Lys Ile Gly Val Val Leu Ser Thr Met Ala 
1               5                   10                  15      


Met Ile Thr Asn Trp Met Ser Gln Thr Leu Pro Ser Leu Val Gly Leu 
            20                  25                  30          


Asn Thr Thr Lys Leu Ser Ala Ala Gly Gly Gly Thr Leu Asp Arg Ser 
        35                  40                  45              


Thr Gly Val Leu Pro Thr Asn Pro Glu Glu Ser Trp Gln Val Tyr Ser 
    50                  55                  60                  


Ser Ala Gln Asp Ser Glu Gly Arg Cys Ile Cys Thr Val Val Ala Pro 
65                  70                  75                  80  


Gln Gln Thr Met Cys Ser Arg Asp Ala Arg Thr Lys Gln Leu Arg Gln 
                85                  90                  95      


Leu Leu Glu Lys Val Gln Asn Met Ser Gln Ser Ile Glu Val Leu Asp 
            100                 105                 110         


Arg Arg Thr Gln Arg Asp Leu Gln Tyr Val Glu Lys Met Glu Asn Gln 
        115                 120                 125             


Met Lys Gly Leu Glu Ser Lys Phe Lys Gln Val Glu Glu Ser His Lys 
    130                 135                 140                 


Gln His Leu Ala Arg Gln Phe Lys Ala Ile Lys Ala Lys Met Asp Glu 
145                 150                 155                 160 


Leu Arg Pro Leu Ile Pro Val Leu Glu Glu Tyr Lys Ala Asp Ala Lys 
                165                 170                 175     


Leu Val Leu Gln Phe Lys Glu Glu Val Gln Asn Leu Thr Ser Val Leu 
            180                 185                 190         


Asn Glu Leu Gln Glu Glu Ile Gly Ala Tyr Asp Tyr Asp Glu Leu Gln 
        195                 200                 205             


Ser Arg Val Ser Asn Leu Glu Glu Arg Leu Arg Ala Cys Met Gln Lys 
    210                 215                 220                 


Leu Ala Cys Gly Lys Leu Thr Gly Ile Ser Asp Pro Val Thr Val Lys 
225                 230                 235                 240 


Thr Ser Gly Ser Arg Phe Gly Ser Trp Met Thr Asp Pro Leu Ala Pro 
                245                 250                 255     


Glu Gly Asp Asn Arg Val Trp Tyr Met Asp Gly Tyr His Asn Asn Arg 
            260                 265                 270         


Phe Val Arg Glu Tyr Lys Ser Met Val Asp Phe Met Asn Thr Asp Asn 
        275                 280                 285             


Phe Thr Ser His Arg Leu Pro His Pro Trp Ser Gly Thr Gly Gln Val 
    290                 295                 300                 


Val Tyr Asn Gly Ser Ile Tyr Phe Asn Lys Phe Gln Ser His Ile Ile 
305                 310                 315                 320 


Ile Arg Phe Asp Leu Lys Thr Glu Thr Ile Leu Lys Thr Arg Ser Leu 
                325                 330                 335     


Asp Tyr Ala Gly Tyr Asn Asn Met Tyr His Tyr Ala Trp Gly Gly His 
            340                 345                 350         


Ser Asp Ile Asp Leu Met Val Asp Glu Ser Gly Leu Trp Ala Val Tyr 
        355                 360                 365             


Ala Thr Asn Gln Asn Ala Gly Asn Ile Val Val Ser Arg Leu Asp Pro 
    370                 375                 380                 


Val Ser Leu Gln Thr Leu Gln Thr Trp Asn Thr Ser Tyr Pro Lys Arg 
385                 390                 395                 400 


Ser Ala Gly Glu Ala Phe Ile Ile Cys Gly Thr Leu Tyr Val Thr Asn 
                405                 410                 415     


Gly Tyr Ser Gly Gly Thr Lys Val His Tyr Ala Tyr Gln Thr Asn Ala 
            420                 425                 430         


Ser Thr Tyr Glu Tyr Ile Asp Ile Pro Phe Gln Asn Lys Tyr Ser His 
        435                 440                 445             


Ile Ser Met Leu Asp Tyr Asn Pro Lys Asp Arg Ala Leu Tyr Ala Trp 
    450                 455                 460                 


Asn Asn Gly His Gln Ile Leu Tyr Asn Val Thr Leu Phe His Val Ile 
465                 470                 475                 480 


Arg Ser Asp Glu Leu 
                485 


<210>  9783
<211>  153
<212>  PRT
<213>  Homo Sapiens

<400>  9783

Met Ser Val Pro Leu Leu Lys Ile Gly Val Val Leu Ser Thr Met Ala 
1               5                   10                  15      


Met Ile Thr Asn Trp Met Ser Gln Thr Leu Pro Ser Leu Val Gly Leu 
            20                  25                  30          


Asn Thr Thr Lys Leu Ser Ala Ala Gly Gly Gly Thr Leu Asp Arg Ser 
        35                  40                  45              


Thr Gly Val Leu Pro Thr Asn Pro Glu Glu Ser Trp Gln Val Tyr Ser 
    50                  55                  60                  


Ser Ala Gln Asp Ser Glu Gly Arg Cys Ile Cys Thr Val Val Ala Pro 
65                  70                  75                  80  


Gln Gln Thr Met Cys Ser Arg Asp Ala Arg Thr Lys Gln Leu Arg Gln 
                85                  90                  95      


Leu Leu Glu Lys Val Gln Asn Met Ser Gln Ser Ile Glu Val Leu Asp 
            100                 105                 110         


Arg Arg Thr Gln Arg Asp Leu Gln Tyr Val Glu Lys Met Glu Asn Gln 
        115                 120                 125             


Met Lys Gly Leu Glu Ser Lys Phe Lys Gln Val Glu Glu Ser His Lys 
    130                 135                 140                 


Gln His Leu Ala Arg Gln Phe Lys Gly 
145                 150             


<210>  9784
<211>  99
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9784

Xaa Ser His Lys Gln His Leu Ala Arg Gln Phe Lys Ala Ile Lys Ala 
1               5                   10                  15      


Lys Met Asp Glu Leu Arg Pro Leu Ile Pro Val Leu Glu Glu Tyr Lys 
            20                  25                  30          


Ala Asp Ala Lys Leu Val Leu Gln Phe Lys Glu Glu Val Gln Asn Leu 
        35                  40                  45              


Thr Ser Val Leu Asn Glu Leu Gln Glu Glu Ile Gly Ala Tyr Asp Tyr 
    50                  55                  60                  


Asp Glu Leu Gln Ser Arg Val Ser Asn Leu Glu Glu Arg Leu Arg Ala 
65                  70                  75                  80  


Cys Met Gln Lys Leu Gly Val Val His Gly Arg Leu Ser Gln Gln Pro 
                85                  90                  95      


Leu Arg Thr 
            


<210>  9785
<211>  78
<212>  PRT
<213>  Homo Sapiens

<400>  9785

Met Glu Val Leu Glu Leu Arg Thr Tyr Arg Asp Leu Gln Tyr Val Arg 
1               5                   10                  15      


Gly Met Glu Thr Leu Met Arg Ser Leu Asp Ala Arg Leu Arg Ala Ala 
            20                  25                  30          


Asp Gly Ser Leu Ser Ala Lys Ser Phe Gln Glu Leu Lys Asp Arg Met 
        35                  40                  45              


Thr Glu Leu Leu Pro Leu Ser Ser Val Leu Glu Gln Tyr Lys Ala Asp 
    50                  55                  60                  


Thr Arg Thr Ile Val Arg Leu Arg Glu Glu Ala Val Gly Ser 
65                  70                  75              


<210>  9786
<211>  376
<212>  PRT
<213>  Homo Sapiens

<400>  9786

Met Glu Val Leu Glu Leu Arg Thr Tyr Arg Asp Leu Gln Tyr Val Arg 
1               5                   10                  15      


Gly Met Glu Thr Leu Met Arg Ser Leu Asp Ala Arg Leu Arg Ala Ala 
            20                  25                  30          


Asp Gly Ser Leu Ser Ala Lys Ser Phe Gln Glu Leu Lys Asp Arg Met 
        35                  40                  45              


Thr Glu Leu Leu Pro Leu Ser Ser Val Leu Glu Gln Tyr Lys Ala Asp 
    50                  55                  60                  


Thr Arg Thr Ile Val Arg Leu Arg Glu Glu Val Arg Asn Leu Ser Gly 
65                  70                  75                  80  


Ser Leu Ala Ala Ile Gln Glu Glu Met Gly Ala Tyr Gly Tyr Glu Asp 
                85                  90                  95      


Leu Gln Gln Arg Val Met Ala Leu Glu Ala Arg Leu His Ala Cys Ala 
            100                 105                 110         


Gln Lys Leu Gly Cys Gly Lys Leu Thr Gly Val Ser Asn Pro Ile Thr 
        115                 120                 125             


Val Arg Ala Met Gly Ser Arg Phe Gly Ser Trp Met Thr Asp Thr Met 
    130                 135                 140                 


Ala Pro Ser Ala Asp Ser Arg Val Trp Tyr Met Asp Gly Tyr Tyr Lys 
145                 150                 155                 160 


Gly Arg Arg Val Leu Glu Phe Arg Thr Leu Gly Asp Phe Ile Lys Gly 
                165                 170                 175     


Gln Asn Phe Ile Gln His Leu Leu Pro Gln Pro Trp Ala Gly Thr Gly 
            180                 185                 190         


His Val Val Tyr Asn Gly Ser Leu Phe Tyr Asn Lys Tyr Gln Ser Asn 
        195                 200                 205             


Val Val Val Lys Tyr His Phe Arg Ser Arg Ser Val Leu Val Gln Arg 
    210                 215                 220                 


Ser Leu Pro Gly Ala Gly Tyr Asn Asn Thr Phe Pro Tyr Ser Trp Gly 
225                 230                 235                 240 


Gly Phe Ser Asp Met Asp Phe Met Val Asp Glu Ser Gly Leu Trp Ala 
                245                 250                 255     


Val Tyr Thr Thr Asn Gln Asn Ala Gly Asn Ile Val Val Ser Arg Leu 
            260                 265                 270         


Asp Pro His Thr Leu Glu Val Met Arg Ser Trp Asp Thr Gly Tyr Pro 
        275                 280                 285             


Lys Arg Ser Ala Gly Glu Ala Phe Met Ile Cys Gly Val Leu Tyr Val 
    290                 295                 300                 


Thr Asn Ser His Leu Ala Gly Ala Lys Val Tyr Phe Ala Tyr Phe Thr 
305                 310                 315                 320 


Asn Thr Ser Ser Tyr Glu Tyr Thr Asp Val Pro Phe His Asn Gln Tyr 
                325                 330                 335     


Ser His Ile Ser Met Leu Asp Tyr Asn Pro Arg Glu Arg Ala Leu Tyr 
            340                 345                 350         


Thr Trp Asn Asn Gly His Gln Val Leu Tyr Asn Val Thr Leu Phe His 
        355                 360                 365             


Val Ile Ser Thr Ser Gly Asp Pro 
    370                 375     


<210>  9787
<211>  336
<212>  PRT
<213>  Homo Sapiens

<400>  9787

Met Ser Val Pro Leu Leu Lys Ile Gly Ala Val Leu Ser Thr Met Ala 
1               5                   10                  15      


Met Val Thr Asn Trp Met Ser Gln Thr Leu Pro Ser Leu Val Gly Leu 
            20                  25                  30          


Asn Gly Thr Val Ser Arg Ala Gly Ala Ser Glu Lys Ile Thr Leu Phe 
        35                  40                  45              


Gln Asn Pro Glu Glu Gly Trp Gln Leu Tyr Thr Ser Ala Gln Ala Pro 
    50                  55                  60                  


Asp Gly Lys Cys Ile Cys Thr Ala Val Ile Pro Ala Gln Ser Thr Cys 
65                  70                  75                  80  


Ser Arg Asp Gly Arg Ser Arg Glu Leu Arg Gln Leu Met Glu Lys Val 
                85                  90                  95      


Gln Asn Val Ser Gln Ser Met Glu Val Leu Glu Leu Arg Thr Tyr Arg 
            100                 105                 110         


Asp Leu Gln Tyr Val Arg Gly Met Glu Thr Leu Met Arg Ser Leu Asp 
        115                 120                 125             


Ala Arg Leu Arg Ala Ala Asp Gly Ser Leu Ser Ala Lys Ser Phe Gln 
    130                 135                 140                 


Glu Leu Lys Asp Arg Met Thr Glu Leu Leu Pro Leu Ser Ser Val Leu 
145                 150                 155                 160 


Glu Gln Tyr Lys Ala Asp Thr Arg Thr Ile Val Arg Leu Arg Glu Glu 
                165                 170                 175     


Val Arg Asn Leu Ser Gly Ser Leu Ala Ala Ile Gln Glu Glu Met Gly 
            180                 185                 190         


Ala Tyr Gly Tyr Glu Asp Leu Gln Gln Arg Val Met Ala Leu Glu Ala 
        195                 200                 205             


Arg Leu His Ala Cys Ala Gln Lys Leu Gly Cys Gly Lys Leu Thr Gly 
    210                 215                 220                 


Val Ser Asn Pro Ile Thr Val Arg Ala Met Gly Ser Arg Phe Gly Ser 
225                 230                 235                 240 


Trp Met Thr Asp Thr Met Ala Pro Ser Ala Asp Ser Arg Val Trp Tyr 
                245                 250                 255     


Met Asp Gly Tyr Tyr Lys Gly Arg Arg Val Leu Glu Phe Arg Thr Leu 
            260                 265                 270         


Gly Asp Phe Ile Lys Gly Gln Asn Phe Ile Gln His Leu Leu Pro Gln 
        275                 280                 285             


Pro Trp Ala Gly Thr Gly His Val Val Tyr Asn Gly Ser Leu Phe Tyr 
    290                 295                 300                 


Asn Lys Tyr Gln Ser Asn Val Val Val Lys Tyr His Phe Arg Ser Arg 
305                 310                 315                 320 


Ser Val Leu Val Gln Arg Ser Leu Pro Gly Ala Gly Tyr Asn Asn Thr 
                325                 330                 335     


<210>  9788
<211>  454
<212>  PRT
<213>  Homo Sapiens

<400>  9788

Met Trp Pro Leu Thr Val Pro Pro Pro Leu Leu Leu Leu Leu Cys Ser 
1               5                   10                  15      


Gly Leu Ala Gly Gln Thr Leu Phe Gln Asn Pro Glu Glu Gly Trp Gln 
            20                  25                  30          


Leu Tyr Thr Ser Ala Gln Ala Pro Asp Gly Lys Cys Ile Cys Thr Ala 
        35                  40                  45              


Val Ile Pro Ala Gln Ser Thr Cys Ser Arg Asp Gly Arg Ser Arg Glu 
    50                  55                  60                  


Leu Arg Gln Leu Met Glu Lys Val Gln Asn Val Ser Gln Ser Met Glu 
65                  70                  75                  80  


Val Leu Glu Leu Arg Thr Tyr Arg Asp Leu Gln Tyr Val Arg Gly Met 
                85                  90                  95      


Glu Thr Leu Met Arg Ser Leu Asp Ala Arg Leu Arg Ala Ala Asp Gly 
            100                 105                 110         


Ser Leu Ser Ala Lys Ser Phe Gln Glu Leu Lys Asp Arg Met Thr Glu 
        115                 120                 125             


Leu Leu Pro Leu Ser Ser Val Leu Glu Gln Tyr Lys Ala Asp Thr Arg 
    130                 135                 140                 


Thr Ile Val Arg Leu Arg Glu Glu Val Arg Asn Leu Ser Gly Ser Leu 
145                 150                 155                 160 


Ala Ala Ile Gln Glu Glu Met Gly Ala Tyr Gly Tyr Glu Asp Leu Gln 
                165                 170                 175     


Gln Arg Val Met Ala Leu Glu Ala Arg Leu His Ala Cys Ala Gln Lys 
            180                 185                 190         


Leu Gly Cys Gly Lys Leu Thr Gly Val Ser Asn Pro Ile Thr Val Arg 
        195                 200                 205             


Ala Met Gly Ser Arg Phe Gly Ser Trp Met Thr Asp Thr Met Ala Pro 
    210                 215                 220                 


Ser Ala Asp Ser Arg Val Trp Tyr Met Asp Gly Tyr Tyr Lys Gly Arg 
225                 230                 235                 240 


Arg Val Leu Glu Phe Arg Thr Leu Gly Asp Phe Ile Lys Gly Gln Asn 
                245                 250                 255     


Phe Ile Gln His Leu Leu Pro Gln Pro Trp Ala Gly Thr Gly His Val 
            260                 265                 270         


Val Tyr Asn Gly Ser Leu Phe Tyr Asn Lys Tyr Gln Ser Asn Val Val 
        275                 280                 285             


Val Lys Tyr His Phe Arg Ser Arg Ser Val Leu Val Gln Arg Ser Leu 
    290                 295                 300                 


Pro Gly Ala Gly Tyr Asn Asn Thr Phe Pro Tyr Ser Trp Gly Gly Phe 
305                 310                 315                 320 


Ser Asp Met Asp Phe Met Val Asp Glu Ser Gly Leu Trp Ala Val Tyr 
                325                 330                 335     


Thr Thr Asn Gln Asn Ala Gly Asn Ile Val Val Ser Arg Leu Asp Pro 
            340                 345                 350         


His Thr Leu Glu Val Met Arg Ser Trp Asp Thr Gly Tyr Pro Lys Arg 
        355                 360                 365             


Ser Ala Gly Glu Ala Phe Met Ile Cys Gly Val Leu Tyr Val Thr Asn 
    370                 375                 380                 


Ser His Leu Ala Gly Ala Lys Val Tyr Phe Ala Tyr Phe Thr Asn Thr 
385                 390                 395                 400 


Ser Ser Tyr Glu Tyr Thr Asp Val Pro Phe His Asn Gln Tyr Ser His 
                405                 410                 415     


Ile Ser Met Leu Asp Tyr Asn Pro Arg Glu Arg Ala Leu Tyr Thr Trp 
            420                 425                 430         


Asn Asn Gly His Gln Val Leu Tyr Asn Val Thr Leu Phe His Val Ile 
        435                 440                 445             


Ser Thr Ser Gly Asp Pro 
    450                 


<210>  9789
<211>  458
<212>  PRT
<213>  Homo Sapiens

<400>  9789

Met Gln Ala Thr Ser Asn Leu Leu Asn Leu Leu Leu Leu Ser Leu Phe 
1               5                   10                  15      


Ala Gly Leu Asp Pro Ser Lys Thr Gln Ile Ser Pro Lys Glu Gly Trp 
            20                  25                  30          


Gln Val Tyr Ser Ser Ala Gln Asp Pro Asp Gly Arg Cys Ile Cys Thr 
        35                  40                  45              


Val Val Ala Pro Glu Gln Asn Leu Cys Ser Arg Asp Ala Lys Ser Arg 
    50                  55                  60                  


Gln Leu Arg Gln Leu Leu Glu Lys Val Gln Asn Met Ser Gln Ser Ile 
65                  70                  75                  80  


Glu Val Leu Asn Leu Arg Thr Gln Arg Asp Phe Gln Tyr Val Leu Lys 
                85                  90                  95      


Met Glu Thr Gln Met Lys Gly Leu Lys Ala Lys Phe Arg Gln Ile Glu 
            100                 105                 110         


Asp Asp Arg Lys Thr Leu Met Thr Lys His Phe Gln Glu Leu Lys Glu 
        115                 120                 125             


Lys Met Asp Glu Leu Leu Pro Leu Ile Pro Val Leu Glu Gln Tyr Lys 
    130                 135                 140                 


Thr Asp Ala Lys Leu Ile Thr Gln Phe Lys Glu Glu Ile Arg Asn Leu 
145                 150                 155                 160 


Ser Ala Val Leu Thr Gly Ile Gln Glu Glu Ile Gly Ala Tyr Asp Tyr 
                165                 170                 175     


Glu Glu Leu His Gln Arg Val Leu Ser Leu Glu Thr Arg Leu Arg Asp 
            180                 185                 190         


Cys Met Lys Lys Leu Thr Cys Gly Lys Leu Met Lys Ile Thr Gly Pro 
        195                 200                 205             


Val Thr Val Lys Thr Ser Gly Thr Arg Phe Gly Ala Trp Met Thr Asp 
    210                 215                 220                 


Pro Leu Ala Ser Glu Lys Asn Asn Arg Val Trp Tyr Met Asp Ser Tyr 
225                 230                 235                 240 


Thr Asn Asn Lys Ile Val Arg Glu Tyr Lys Ser Ile Ala Asp Phe Val 
                245                 250                 255     


Ser Gly Ala Glu Ser Arg Thr Tyr Asn Leu Pro Phe Lys Trp Ala Gly 
            260                 265                 270         


Thr Asn His Val Val Tyr Asn Gly Ser Leu Tyr Phe Asn Lys Tyr Gln 
        275                 280                 285             


Ser Asn Ile Ile Ile Lys Tyr Ser Phe Asp Met Gly Arg Val Leu Ala 
    290                 295                 300                 


Gln Arg Ser Leu Glu Tyr Ala Gly Phe His Asn Val Tyr Pro Tyr Thr 
305                 310                 315                 320 


Trp Gly Gly Phe Ser Asp Ile Asp Leu Met Ala Asp Glu Ile Gly Leu 
                325                 330                 335     


Trp Ala Val Tyr Ala Thr Asn Gln Asn Ala Gly Asn Ile Val Ile Ser 
            340                 345                 350         


Gln Leu Asn Gln Asp Thr Leu Glu Val Met Lys Ser Trp Ser Thr Gly 
        355                 360                 365             


Tyr Pro Lys Arg Ser Ala Gly Glu Ser Phe Met Ile Cys Gly Thr Leu 
    370                 375                 380                 


Tyr Val Thr Asn Ser His Leu Thr Gly Ala Lys Val Tyr Tyr Ser Tyr 
385                 390                 395                 400 


Ser Thr Lys Thr Ser Thr Tyr Glu Tyr Thr Asp Ile Pro Phe His Asn 
                405                 410                 415     


Gln Tyr Phe His Ile Ser Met Leu Asp Tyr Asn Ala Arg Asp Arg Ala 
            420                 425                 430         


Leu Tyr Ala Trp Asn Asn Gly His Gln Val Leu Phe Asn Val Thr Leu 
        435                 440                 445             


Phe His Ile Ile Lys Thr Glu Asp Asp Thr 
    450                 455             


<210>  9790
<211>  478
<212>  PRT
<213>  Homo Sapiens

<400>  9790

Met Ser Pro Pro Leu Leu Lys Leu Gly Ala Val Leu Ser Thr Met Ala 
1               5                   10                  15      


Met Ile Ser Asn Trp Met Ser Gln Thr Leu Pro Ser Leu Val Gly Leu 
            20                  25                  30          


Asn Thr Thr Arg Leu Ser Thr Pro Asp Thr Leu Thr Gln Ile Ser Pro 
        35                  40                  45              


Lys Glu Gly Trp Gln Val Tyr Ser Ser Ala Gln Asp Pro Asp Gly Arg 
    50                  55                  60                  


Cys Ile Cys Thr Val Val Ala Pro Glu Gln Asn Leu Cys Ser Arg Asp 
65                  70                  75                  80  


Ala Lys Ser Arg Gln Leu Arg Gln Leu Leu Glu Lys Val Gln Asn Met 
                85                  90                  95      


Ser Gln Ser Ile Glu Val Leu Asn Leu Arg Thr Gln Arg Asp Phe Gln 
            100                 105                 110         


Tyr Val Leu Lys Met Glu Thr Gln Met Lys Gly Leu Lys Ala Lys Phe 
        115                 120                 125             


Arg Gln Ile Glu Asp Asp Arg Lys Thr Leu Met Thr Lys His Phe Gln 
    130                 135                 140                 


Glu Leu Lys Glu Lys Met Asp Glu Leu Leu Pro Leu Ile Pro Val Leu 
145                 150                 155                 160 


Glu Gln Tyr Lys Thr Asp Ala Lys Leu Ile Thr Gln Phe Lys Glu Glu 
                165                 170                 175     


Ile Arg Asn Leu Ser Ala Val Leu Thr Gly Ile Gln Glu Glu Ile Gly 
            180                 185                 190         


Ala Tyr Asp Tyr Glu Glu Leu His Gln Arg Val Leu Ser Leu Glu Thr 
        195                 200                 205             


Arg Leu Arg Asp Cys Met Lys Lys Leu Thr Cys Gly Lys Leu Met Lys 
    210                 215                 220                 


Ile Thr Gly Pro Val Thr Val Lys Thr Ser Gly Thr Arg Phe Gly Ala 
225                 230                 235                 240 


Trp Met Thr Asp Pro Leu Ala Ser Glu Lys Asn Asn Arg Val Trp Tyr 
                245                 250                 255     


Met Asp Ser Tyr Thr Asn Asn Lys Ile Val Arg Glu Tyr Lys Ser Ile 
            260                 265                 270         


Ala Asp Phe Val Ser Gly Ala Glu Ser Arg Thr Tyr Asn Leu Pro Phe 
        275                 280                 285             


Lys Trp Ala Gly Thr Asn His Val Val Tyr Asn Gly Ser Leu Tyr Phe 
    290                 295                 300                 


Asn Lys Tyr Gln Ser Asn Ile Ile Ile Lys Tyr Ser Phe Asp Met Gly 
305                 310                 315                 320 


Arg Val Leu Ala Gln Arg Ser Leu Glu Tyr Ala Gly Phe His Asn Val 
                325                 330                 335     


Tyr Pro Tyr Thr Trp Gly Gly Phe Ser Asp Ile Asp Leu Met Ala Asp 
            340                 345                 350         


Glu Ile Gly Leu Trp Ala Val Tyr Ala Thr Asn Gln Asn Ala Gly Asn 
        355                 360                 365             


Ile Val Ile Ser Gln Leu Asn Gln Asp Thr Leu Glu Val Met Lys Ser 
    370                 375                 380                 


Trp Ser Thr Gly Tyr Pro Lys Arg Ser Ala Gly Glu Ser Phe Met Ile 
385                 390                 395                 400 


Cys Gly Thr Leu Tyr Val Thr Asn Ser His Leu Thr Gly Ala Lys Val 
                405                 410                 415     


Tyr Tyr Ser Tyr Ser Thr Lys Thr Ser Thr Tyr Glu Tyr Thr Asp Ile 
            420                 425                 430         


Pro Phe His Asn Gln Tyr Phe His Ile Ser Met Leu Asp Tyr Asn Ala 
        435                 440                 445             


Arg Asp Arg Ala Leu Tyr Ala Trp Asn Asn Gly His Gln Val Leu Phe 
    450                 455                 460                 


Asn Val Thr Leu Phe His Ile Ile Lys Thr Glu Asp Asp Thr 
465                 470                 475             


<210>  9791
<211>  140
<212>  PRT
<213>  Homo Sapiens

<400>  9791

Met Ser Gln Ser Ile Glu Val Leu Asn Leu Arg Thr Gln Arg Asp Phe 
1               5                   10                  15      


Gln Tyr Val Leu Lys Met Glu Thr Gln Met Lys Gly Leu Lys Ala Lys 
            20                  25                  30          


Phe Arg Gln Ile Glu Asp Asp Arg Lys Thr Leu Met Thr Lys His Phe 
        35                  40                  45              


Gln Glu Leu Lys Glu Lys Met Asp Glu Leu Leu Pro Leu Ile Pro Val 
    50                  55                  60                  


Leu Glu Gln Tyr Lys Thr Asp Ala Lys Leu Ile Thr Gln Phe Lys Glu 
65                  70                  75                  80  


Glu Ile Arg Asn Leu Ser Ala Val Leu Thr Gly Ile Gln Glu Glu Ile 
                85                  90                  95      


Gly Ala Tyr Asp Tyr Glu Glu Leu His Gln Arg Val Leu Ser Leu Glu 
            100                 105                 110         


Thr Arg Leu Arg Asp Cys Met Lys Lys Leu Ile Asp Leu Lys Lys Arg 
        115                 120                 125             


Lys Glu Glu Glu Lys Arg Gln Gln Lys Gly Glu Ala 
    130                 135                 140 


<210>  9792
<211>  510
<212>  PRT
<213>  Homo Sapiens

<400>  9792

Met Arg Pro Gly Leu Ser Phe Leu Leu Ala Leu Leu Phe Phe Leu Gly 
1               5                   10                  15      


Gln Ala Ala Gly Asp Leu Gly Asp Val Gly Pro Pro Ile Pro Ser Pro 
            20                  25                  30          


Gly Phe Ser Ser Phe Pro Gly Val Asp Ser Ser Ser Ser Phe Ser Ser 
        35                  40                  45              


Ser Ser Arg Ser Gly Ser Ser Ser Ser Arg Ser Leu Gly Ser Gly Gly 
    50                  55                  60                  


Ser Val Ser Gln Leu Phe Ser Asn Phe Thr Gly Ser Val Asp Asp Arg 
65                  70                  75                  80  


Gly Thr Cys Gln Cys Ser Val Ser Leu Pro Asp Thr Thr Phe Pro Val 
                85                  90                  95      


Asp Arg Val Glu Arg Leu Glu Phe Thr Ala His Val Leu Ser Gln Lys 
            100                 105                 110         


Phe Glu Lys Glu Leu Ser Lys Val Arg Glu Tyr Val Gln Leu Ile Ser 
        115                 120                 125             


Val Tyr Glu Lys Lys Leu Leu Asn Leu Thr Val Arg Ile Asp Ile Met 
    130                 135                 140                 


Glu Lys Asp Thr Ile Ser Tyr Thr Glu Leu Asp Phe Glu Leu Ile Lys 
145                 150                 155                 160 


Val Glu Val Lys Glu Met Glu Lys Leu Val Ile Gln Leu Lys Glu Ser 
                165                 170                 175     


Phe Gly Gly Ser Ser Glu Ile Val Asp Gln Leu Glu Val Glu Ile Arg 
            180                 185                 190         


Asn Met Thr Leu Leu Val Glu Lys Leu Glu Thr Leu Asp Lys Asn Asn 
        195                 200                 205             


Val Leu Ala Ile Arg Arg Glu Ile Val Ala Leu Lys Thr Lys Leu Lys 
    210                 215                 220                 


Glu Cys Glu Ala Ser Lys Asp Gln Asn Thr Pro Val Val His Pro Pro 
225                 230                 235                 240 


Pro Thr Pro Gly Ser Cys Gly His Gly Gly Val Val Asn Ile Ser Lys 
                245                 250                 255     


Pro Ser Val Val Gln Leu Asn Trp Arg Gly Phe Ser Tyr Leu Tyr Gly 
            260                 265                 270         


Ala Trp Gly Arg Asp Tyr Ser Pro Gln His Pro Asn Lys Gly Leu Tyr 
        275                 280                 285             


Trp Val Ala Pro Leu Asn Thr Asp Gly Arg Leu Leu Glu Tyr Tyr Arg 
    290                 295                 300                 


Leu Tyr Asn Thr Leu Asp Asp Leu Leu Leu Tyr Ile Asn Ala Arg Glu 
305                 310                 315                 320 


Leu Arg Ile Thr Tyr Gly Gln Gly Ser Gly Thr Ala Val Tyr Asn Asn 
                325                 330                 335     


Asn Met Tyr Val Asn Met Tyr Asn Thr Gly Asn Ile Ala Arg Val Asn 
            340                 345                 350         


Leu Thr Thr Asn Thr Ile Ala Val Thr Gln Thr Leu Pro Asn Ala Ala 
        355                 360                 365             


Tyr Asn Asn Arg Phe Ser Tyr Ala Asn Val Ala Trp Gln Asp Ile Asp 
    370                 375                 380                 


Phe Ala Val Asp Glu Asn Gly Leu Trp Val Ile Tyr Ser Thr Glu Ala 
385                 390                 395                 400 


Ser Thr Gly Asn Met Val Ile Ser Lys Leu Asn Asp Thr Thr Leu Gln 
                405                 410                 415     


Val Leu Asn Thr Trp Tyr Thr Lys Gln Tyr Lys Pro Ser Ala Ser Asn 
            420                 425                 430         


Ala Phe Met Val Cys Gly Val Leu Tyr Ala Thr Arg Thr Met Asn Thr 
        435                 440                 445             


Arg Thr Glu Glu Ile Phe Tyr Tyr Tyr Asp Thr Asn Thr Gly Lys Glu 
    450                 455                 460                 


Gly Lys Leu Asp Ile Val Met His Lys Met Gln Glu Lys Val Gln Ser 
465                 470                 475                 480 


Ile Asn Tyr Asn Pro Phe Asp Gln Lys Leu Tyr Val Tyr Asn Asp Gly 
                485                 490                 495     


Tyr Leu Leu Asn Tyr Asp Leu Ser Val Leu Gln Lys Pro Gln 
            500                 505                 510 


<210>  9793
<211>  68
<212>  PRT
<213>  Homo Sapiens

<400>  9793

Met Met Val Ala Leu Arg Gly Ala Ser Ala Leu Leu Val Leu Phe Leu 
1               5                   10                  15      


Ala Ala Phe Leu Pro Pro Pro Gln Cys Thr Gln Asp Pro Ala Met Val 
            20                  25                  30          


His Tyr Ile Tyr Gln Arg Phe Arg Val Leu Glu Gly Trp Lys Asn Val 
        35                  40                  45              


Pro Lys Gln Arg Gly His Thr Phe Lys Asn Ser Lys Ser Ser Gln Lys 
    50                  55                  60                  


Ile Tyr Leu Ser 
65              


<210>  9794
<211>  402
<212>  PRT
<213>  Homo Sapiens

<400>  9794

Met Met Val Ala Leu Arg Gly Ala Ser Ala Leu Leu Val Leu Phe Leu 
1               5                   10                  15      


Ala Ala Phe Leu Pro Pro Pro Gln Cys Thr Gln Asp Pro Ala Met Val 
            20                  25                  30          


His Tyr Ile Tyr Gln Arg Phe Arg Val Leu Glu Gln Gly Leu Glu Lys 
        35                  40                  45              


Cys Thr Gln Ala Thr Arg Ala Tyr Ile Gln Glu Phe Gln Glu Phe Ser 
    50                  55                  60                  


Lys Asn Ile Ser Val Met Leu Gly Arg Cys Gln Thr Tyr Thr Ser Glu 
65                  70                  75                  80  


Tyr Lys Ser Ala Val Gly Asn Leu Ala Leu Arg Val Glu Arg Ala Gln 
                85                  90                  95      


Arg Glu Ile Asp Tyr Ile Gln Tyr Leu Arg Glu Ala Asp Glu Cys Ile 
            100                 105                 110         


Glu Ser Glu Asp Lys Thr Leu Ala Glu Met Leu Leu Gln Glu Ala Glu 
        115                 120                 125             


Glu Glu Lys Lys Ile Arg Thr Leu Leu Asn Ala Ser Cys Asp Asn Met 
    130                 135                 140                 


Leu Met Gly Ile Lys Ser Leu Lys Ile Val Lys Lys Met Met Asp Thr 
145                 150                 155                 160 


His Gly Ser Trp Met Lys Asp Ala Val Tyr Asn Ser Pro Lys Val Tyr 
                165                 170                 175     


Leu Leu Ile Gly Ser Arg Asn Asn Thr Val Trp Glu Phe Ala Asn Ile 
            180                 185                 190         


Arg Ala Phe Met Glu Asp Asn Thr Lys Pro Ala Pro Arg Lys Gln Ile 
        195                 200                 205             


Leu Thr Leu Ser Trp Gln Gly Thr Gly Gln Val Ile Tyr Lys Gly Phe 
    210                 215                 220                 


Leu Phe Phe His Asn Gln Ala Thr Ser Asn Glu Ile Ile Lys Tyr Asn 
225                 230                 235                 240 


Leu Gln Lys Arg Thr Val Glu Asp Arg Met Leu Leu Pro Gly Gly Val 
                245                 250                 255     


Gly Arg Ala Leu Val Tyr Gln His Ser Pro Ser Thr Tyr Ile Asp Leu 
            260                 265                 270         


Ala Val Asp Glu His Gly Leu Trp Ala Ile His Ser Gly Pro Gly Thr 
        275                 280                 285             


His Ser His Leu Val Leu Thr Lys Ile Glu Pro Gly Thr Leu Gly Val 
    290                 295                 300                 


Glu His Ser Trp Asp Thr Pro Cys Arg Ser Gln Asp Ala Glu Ala Ser 
305                 310                 315                 320 


Phe Leu Leu Cys Gly Val Leu Tyr Val Val Tyr Ser Thr Gly Gly Gln 
                325                 330                 335     


Gly Pro His Arg Ile Thr Cys Ile Tyr Asp Pro Leu Gly Thr Ile Ser 
            340                 345                 350         


Glu Glu Asp Leu Pro Asn Leu Phe Phe Pro Lys Arg Pro Arg Ser His 
        355                 360                 365             


Ser Met Ile His Tyr Asn Pro Arg Asp Lys Gln Leu Tyr Ala Trp Asn 
    370                 375                 380                 


Glu Gly Asn Gln Ile Ile Tyr Lys Leu Gln Thr Lys Arg Lys Leu Pro 
385                 390                 395                 400 


Leu Lys 
        


<210>  9795
<211>  402
<212>  PRT
<213>  Homo Sapiens

<400>  9795

Met Met Val Ala Leu Arg Gly Ala Ser Ala Leu Leu Val Leu Phe Leu 
1               5                   10                  15      


Ala Ala Phe Leu Pro Pro Pro Gln Cys Thr Gln Asp Pro Ala Met Val 
            20                  25                  30          


His Tyr Ile Tyr Gln Arg Phe Arg Val Leu Glu Gln Gly Leu Glu Lys 
        35                  40                  45              


Cys Thr Gln Ala Thr Arg Ala Tyr Ile Gln Glu Phe Gln Glu Phe Ser 
    50                  55                  60                  


Lys Asn Ile Ser Val Met Leu Gly Arg Cys Gln Thr Tyr Thr Ser Glu 
65                  70                  75                  80  


Tyr Lys Ser Ala Val Gly Asn Leu Ala Leu Arg Val Glu Arg Ala Gln 
                85                  90                  95      


Arg Glu Ile Asp Tyr Ile Gln Tyr Leu Arg Glu Ala Asp Glu Cys Ile 
            100                 105                 110         


Glu Ser Glu Asp Lys Thr Leu Ala Glu Met Leu Leu Gln Glu Ala Glu 
        115                 120                 125             


Glu Glu Lys Lys Ile Arg Thr Leu Leu Asn Ala Ser Cys Asp Asn Met 
    130                 135                 140                 


Leu Met Gly Ile Lys Ser Leu Lys Ile Val Lys Lys Met Met Asp Thr 
145                 150                 155                 160 


His Gly Ser Trp Met Lys Asp Ala Val Tyr Asn Ser Pro Lys Val Tyr 
                165                 170                 175     


Leu Leu Ile Gly Ser Arg Asn Asn Thr Val Trp Glu Phe Ala Asn Ile 
            180                 185                 190         


Arg Ala Phe Met Glu Asp Asn Thr Lys Pro Ala Pro Arg Lys Gln Ile 
        195                 200                 205             


Leu Thr Leu Ser Trp Gln Gly Thr Gly Gln Val Ile Tyr Lys Gly Phe 
    210                 215                 220                 


Leu Phe Phe His Asn Gln Ala Thr Ser Asn Glu Ile Ile Lys Tyr Asn 
225                 230                 235                 240 


Leu Gln Lys Arg Thr Val Glu Asp Arg Met Leu Leu Pro Gly Gly Val 
                245                 250                 255     


Gly Arg Ala Leu Val Tyr Gln His Ser Pro Ser Thr Tyr Ile Asp Leu 
            260                 265                 270         


Ala Val Asp Glu His Gly Leu Trp Ala Ile His Ser Gly Pro Gly Thr 
        275                 280                 285             


His Ser His Leu Val Leu Thr Lys Ile Glu Pro Gly Thr Leu Gly Val 
    290                 295                 300                 


Glu His Ser Trp Asp Thr Pro Cys Arg Ser Gln Asp Ala Glu Ala Ser 
305                 310                 315                 320 


Phe Leu Leu Cys Gly Val Leu Tyr Val Val Tyr Ser Thr Gly Gly Gln 
                325                 330                 335     


Gly Pro His Arg Ile Thr Cys Ile Tyr Asp Pro Leu Gly Thr Ile Ser 
            340                 345                 350         


Glu Glu Asp Leu Pro Asn Leu Phe Phe Pro Lys Arg Pro Arg Ser His 
        355                 360                 365             


Ser Met Ile His Tyr Asn Pro Arg Asp Lys Gln Leu Tyr Ala Trp Asn 
    370                 375                 380                 


Glu Gly Asn Gln Ile Ile Tyr Lys Leu Gln Thr Lys Arg Lys Leu Pro 
385                 390                 395                 400 


Leu Lys 
        


<210>  9796
<211>  56
<212>  PRT
<213>  Homo Sapiens

<400>  9796

Met Met Val Ala Leu Arg Gly Ala Ser Ala Leu Leu Val Leu Phe Leu 
1               5                   10                  15      


Ala Ala Phe Leu Pro Pro Pro Gln Cys Thr Gln Asp Pro Ala Met Val 
            20                  25                  30          


His Tyr Ile Tyr Gln Arg Phe Arg Val Leu Glu Gln Gly Leu Glu Lys 
        35                  40                  45              


Cys Thr Gln Ala Val Thr Thr Cys 
    50                  55      


<210>  9797
<211>  652
<212>  PRT
<213>  Homo Sapiens

<400>  9797

Met Ala Ala Ala Ala Leu Pro Pro Arg Pro Leu Leu Leu Leu Pro Leu 
1               5                   10                  15      


Val Leu Leu Leu Ser Gly Arg Pro Thr Arg Ala Asp Ser Lys Val Phe 
            20                  25                  30          


Gly Asp Leu Asp Gln Val Arg Met Thr Ser Glu Gly Ser Asp Cys Arg 
        35                  40                  45              


Cys Lys Cys Ile Met Arg Pro Leu Ser Lys Asp Ala Cys Ser Arg Val 
    50                  55                  60                  


Arg Ser Gly Arg Ala Arg Val Glu Asp Phe Tyr Thr Val Glu Thr Val 
65                  70                  75                  80  


Ser Ser Gly Thr Asp Cys Arg Cys Ser Cys Thr Ala Pro Pro Ser Ser 
                85                  90                  95      


Leu Asn Pro Cys Glu Asn Glu Trp Lys Met Glu Lys Leu Lys Lys Gln 
            100                 105                 110         


Ala Pro Glu Leu Leu Lys Leu Gln Ser Met Val Asp Leu Leu Glu Gly 
        115                 120                 125             


Thr Leu Tyr Ser Met Asp Leu Met Lys Val His Ala Tyr Val His Lys 
    130                 135                 140                 


Val Ala Ser Gln Met Asn Thr Leu Glu Glu Ser Ile Lys Ala Asn Leu 
145                 150                 155                 160 


Ser Arg Glu Asn Glu Val Val Lys Asp Ser Val Arg His Leu Ser Glu 
                165                 170                 175     


Gln Leu Arg His Tyr Glu Asn His Ser Ala Ile Met Leu Gly Ile Lys 
            180                 185                 190         


Lys Glu Leu Ser Arg Leu Gly Leu Gln Leu Leu Gln Lys Asp Ala Ala 
        195                 200                 205             


Ala Ala Pro Ala Thr Pro Ala Thr Gly Thr Gly Ser Lys Ala Gln Asp 
    210                 215                 220                 


Thr Ala Arg Gly Lys Gly Lys Asp Ile Ser Lys Tyr Gly Ser Val Gln 
225                 230                 235                 240 


Lys Ser Phe Ala Asp Arg Gly Leu Pro Lys Pro Pro Lys Glu Lys Leu 
                245                 250                 255     


Leu Gln Val Glu Lys Leu Arg Lys Glu Ser Gly Lys Gly Ser Phe Leu 
            260                 265                 270         


Gln Pro Thr Ala Lys Pro Arg Ala Leu Ala Gln Gln Gln Ala Val Ile 
        275                 280                 285             


Arg Gly Phe Thr Tyr Tyr Lys Ala Gly Lys Gln Glu Val Thr Glu Ala 
    290                 295                 300                 


Val Ala Asp Asn Thr Leu Gln Gly Thr Ser Trp Leu Glu Gln Leu Pro 
305                 310                 315                 320 


Pro Lys Val Glu Gly Arg Ser Asn Ser Ala Glu Pro Asn Ser Ala Glu 
                325                 330                 335     


Gln Asp Glu Ala Glu Pro Arg Ser Ser Glu Arg Val Asp Leu Ala Ser 
            340                 345                 350         


Gly Thr Pro Thr Ser Ile Pro Ala Thr Thr Thr Thr Ala Thr Thr Thr 
        355                 360                 365             


Pro Thr Pro Thr Thr Ser Leu Leu Pro Thr Glu Pro Pro Ser Gly Pro 
    370                 375                 380                 


Glu Val Ser Ser Gln Gly Arg Glu Ala Ser Cys Glu Gly Thr Leu Arg 
385                 390                 395                 400 


Ala Val Asp Pro Pro Val Arg His His Ser Tyr Gly Arg His Glu Gly 
                405                 410                 415     


Ala Trp Met Lys Asp Pro Ala Ala Arg Asp Asp Arg Ile Tyr Val Thr 
            420                 425                 430         


Asn Tyr Tyr Tyr Gly Asn Ser Leu Val Glu Phe Arg Asn Leu Glu Asn 
        435                 440                 445             


Phe Lys Gln Gly Arg Trp Ser Asn Met Tyr Lys Leu Pro Tyr Asn Trp 
    450                 455                 460                 


Ile Gly Thr Gly His Val Val Tyr Gln Gly Ala Phe Tyr Tyr Asn Arg 
465                 470                 475                 480 


Ala Phe Thr Lys Asn Ile Ile Lys Tyr Asp Leu Arg Gln Arg Phe Val 
                485                 490                 495     


Ala Ser Trp Ala Leu Leu Pro Asp Val Val Tyr Glu Asp Thr Thr Pro 
            500                 505                 510         


Trp Lys Trp Arg Gly His Ser Asp Ile Asp Phe Ala Val Asp Glu Ser 
        515                 520                 525             


Gly Leu Trp Val Ile Tyr Pro Ala Val Asp Asp Arg Asp Glu Ala Gln 
    530                 535                 540                 


Pro Glu Val Ile Val Leu Ser Arg Leu Asp Pro Gly Asp Leu Ser Val 
545                 550                 555                 560 


His Arg Glu Thr Thr Trp Lys Thr Arg Leu Arg Arg Asn Ser Tyr Gly 
                565                 570                 575     


Asn Cys Phe Leu Val Cys Gly Ile Leu Tyr Ala Val Asp Thr Tyr Asn 
            580                 585                 590         


Gln Gln Glu Gly Gln Val Ala Tyr Ala Phe Asp Thr His Thr Gly Thr 
        595                 600                 605             


Asp Ala Arg Pro Gln Leu Pro Phe Leu Asn Glu His Ala Tyr Thr Thr 
    610                 615                 620                 


Gln Ile Asp Tyr Asn Pro Lys Glu Arg Val Leu Tyr Ala Trp Asp Asn 
625                 630                 635                 640 


Gly His Gln Leu Thr Tyr Thr Leu His Phe Val Val 
                645                 650         


<210>  9798
<211>  318
<212>  PRT
<213>  Homo Sapiens

<400>  9798

Met Ala Ala Ala Ala Leu Pro Pro Arg Pro Leu Leu Leu Leu Pro Leu 
1               5                   10                  15      


Val Leu Leu Leu Ser Gly Arg Pro Thr Arg Ala Asp Ser Lys Val Phe 
            20                  25                  30          


Gly Asp Leu Asp Gln Val Arg Met Thr Ser Glu Gly Ser Asp Cys Arg 
        35                  40                  45              


Cys Lys Cys Ile Met Arg Pro Leu Ser Lys Asp Ala Cys Ser Arg Val 
    50                  55                  60                  


Arg Ser Gly Arg Ala Arg Val Glu Asp Phe Tyr Thr Val Glu Thr Val 
65                  70                  75                  80  


Ser Ser Gly Thr Asp Cys Arg Cys Ser Cys Thr Ala Pro Pro Ser Ser 
                85                  90                  95      


Leu Asn Pro Cys Glu Asn Glu Trp Lys Met Glu Lys Leu Lys Lys Gln 
            100                 105                 110         


Ala Pro Glu Leu Leu Lys Ser Ile Lys Ala Asn Leu Ser Arg Glu Asn 
        115                 120                 125             


Glu Val Val Lys Asp Ser Val Arg His Leu Ser Glu Gln Leu Arg His 
    130                 135                 140                 


Tyr Glu Asn His Ser Ala Ile Met Leu Gly Ile Lys Lys Glu Leu Ser 
145                 150                 155                 160 


Arg Leu Gly Leu Gln Leu Leu Gln Lys Asp Ala Ala Ala Ala Pro Ala 
                165                 170                 175     


Thr Pro Ala Thr Gly Thr Gly Ser Lys Ala Gln Asp Thr Ala Arg Gly 
            180                 185                 190         


Lys Gly Lys Asp Ile Ser Lys Tyr Gly Ser Val Gln Lys Ser Phe Ala 
        195                 200                 205             


Asp Arg Gly Leu Pro Lys Pro Pro Lys Glu Lys Leu Leu Gln Val Glu 
    210                 215                 220                 


Lys Leu Arg Lys Glu Ser Gly Lys Gly Ser Phe Leu Gln Pro Thr Ala 
225                 230                 235                 240 


Lys Pro Arg Ala Leu Ala Gln Gln Gln Ala Val Ile Arg Gly Phe Thr 
                245                 250                 255     


Tyr Tyr Lys Ala Gly Lys Gln Glu Val Thr Glu Ala Val Ala Asp Asn 
            260                 265                 270         


Thr Leu Gln Gly Thr Ser Trp Leu Glu Gln Leu Pro Pro Lys Val Glu 
        275                 280                 285             


Gly Arg Ser Asn Ser Ala Glu Pro Asn Ser Ala Glu Gln Asp Glu Ala 
    290                 295                 300                 


Glu Pro Arg Ser Ser Glu Arg Val Asp Leu Ala Ser Gly Thr 
305                 310                 315             


<210>  9799
<211>  438
<212>  PRT
<213>  Homo Sapiens

<400>  9799

Met Ser Lys Arg Asp Lys Ala Gly Lys Asp Thr Ala Arg Gly Lys Gly 
1               5                   10                  15      


Lys Asp Ile Ser Lys Tyr Gly Ser Val Gln Lys Ser Phe Ala Asp Arg 
            20                  25                  30          


Gly Leu Pro Lys Pro Pro Lys Glu Lys Leu Leu Gln Val Glu Lys Leu 
        35                  40                  45              


Arg Lys Glu Ser Gly Lys Gly Ser Phe Leu Gln Pro Thr Ala Lys Pro 
    50                  55                  60                  


Arg Ala Leu Ala Gln Gln Gln Ala Val Ile Arg Gly Phe Thr Tyr Tyr 
65                  70                  75                  80  


Lys Ala Gly Lys Gln Glu Val Thr Glu Ala Val Ala Asp Asn Thr Leu 
                85                  90                  95      


Gln Gly Thr Ser Trp Leu Glu Gln Leu Pro Pro Lys Val Glu Gly Arg 
            100                 105                 110         


Ser Asn Ser Ala Glu Pro Asn Ser Ala Glu Gln Asp Glu Ala Glu Pro 
        115                 120                 125             


Arg Ser Ser Glu Arg Val Asp Leu Ala Ser Gly Thr Pro Thr Ser Ile 
    130                 135                 140                 


Pro Ala Thr Thr Thr Thr Ala Thr Thr Thr Pro Thr Pro Thr Thr Ser 
145                 150                 155                 160 


Leu Leu Pro Thr Glu Pro Pro Ser Gly Pro Glu Val Ser Ser Gln Gly 
                165                 170                 175     


Arg Glu Ala Ser Cys Glu Gly Thr Leu Arg Ala Val Asp Pro Pro Val 
            180                 185                 190         


Arg His His Ser Tyr Gly Arg His Glu Gly Ala Trp Met Lys Asp Pro 
        195                 200                 205             


Ala Ala Arg Asp Asp Arg Ile Tyr Val Thr Asn Tyr Tyr Tyr Gly Asn 
    210                 215                 220                 


Ser Leu Val Glu Phe Arg Asn Leu Glu Asn Phe Lys Gln Gly Arg Trp 
225                 230                 235                 240 


Ser Asn Met Tyr Lys Leu Pro Tyr Asn Trp Ile Gly Thr Gly His Val 
                245                 250                 255     


Val Tyr Gln Gly Ala Phe Tyr Tyr Asn Arg Ala Phe Thr Lys Asn Ile 
            260                 265                 270         


Ile Lys Tyr Asp Leu Arg Gln Arg Phe Val Ala Ser Trp Ala Leu Leu 
        275                 280                 285             


Pro Asp Val Val Tyr Glu Asp Thr Thr Pro Trp Lys Trp Arg Gly His 
    290                 295                 300                 


Ser Asp Ile Asp Phe Ala Val Asp Glu Ser Gly Leu Trp Val Ile Tyr 
305                 310                 315                 320 


Pro Ala Val Asp Asp Arg Asp Glu Ala Gln Pro Glu Val Ile Val Leu 
                325                 330                 335     


Ser Arg Leu Asp Pro Gly Asp Leu Ser Val His Arg Glu Thr Thr Trp 
            340                 345                 350         


Lys Thr Arg Leu Arg Arg Asn Ser Tyr Gly Asn Cys Phe Leu Val Cys 
        355                 360                 365             


Gly Ile Leu Tyr Ala Val Asp Thr Tyr Asn Gln Gln Glu Gly Gln Val 
    370                 375                 380                 


Ala Tyr Ala Phe Asp Thr His Thr Gly Thr Asp Ala Arg Pro Gln Leu 
385                 390                 395                 400 


Pro Phe Leu Asn Glu His Ala Tyr Thr Thr Gln Ile Asp Tyr Asn Pro 
                405                 410                 415     


Lys Glu Arg Val Leu Tyr Ala Trp Asp Asn Gly His Gln Leu Thr Tyr 
            420                 425                 430         


Thr Leu His Phe Val Val 
        435             


<210>  9800
<211>  90
<212>  PRT
<213>  Homo Sapiens

<400>  9800

Glu Thr Thr Trp Arg Thr Gly Leu Arg Arg Asn Phe Tyr Gly Asn Cys 
1               5                   10                  15      


Phe Val Ile Cys Gly Val Leu Tyr Ala Val Asp Ser Tyr Asn Gln Arg 
            20                  25                  30          


Asn Ala Asn Ile Ser Tyr Ala Phe Asp Thr His Thr Asn Thr Gln Ile 
        35                  40                  45              


Val Pro Arg Leu Leu Phe Glu Asn Glu Tyr Ser Tyr Thr Thr Gln Ile 
    50                  55                  60                  


Asp Tyr Asn Pro Lys Asp Arg Leu Leu Tyr Ala Trp Asp Asn Gly His 
65                  70                  75                  80  


Gln Val Thr Tyr His Val Ile Phe Ala Tyr 
                85                  90  


<210>  9801
<211>  751
<212>  PRT
<213>  Homo Sapiens

<400>  9801

Met Ala Lys Pro Arg Leu Leu Val Leu Tyr Phe Ala Leu Ile Val Val 
1               5                   10                  15      


Pro Ala Trp Val Ser Ser Ile Val Leu Thr Gly Thr Ser Glu Pro Pro 
            20                  25                  30          


Asp Ala Gln Thr Val Ala Pro Ala Glu Asp Glu Thr Leu Gln Asn Glu 
        35                  40                  45              


Ala Asp Asn Gln Glu Asn Val Leu Ser Gln Leu Leu Gly Asp Tyr Asp 
    50                  55                  60                  


Lys Val Lys Ala Met Ser Glu Gly Ser Asp Cys Gln Cys Lys Cys Val 
65                  70                  75                  80  


Val Arg Pro Leu Gly Arg Asp Ala Cys Gln Arg Ile Asn Ala Gly Ala 
                85                  90                  95      


Ser Arg Lys Glu Asp Phe Tyr Thr Val Glu Thr Ile Thr Ser Gly Ser 
            100                 105                 110         


Ser Cys Lys Cys Ala Cys Val Ala Pro Pro Ser Ala Leu Asn Pro Cys 
        115                 120                 125             


Glu Gly Asp Phe Arg Leu Gln Lys Leu Arg Glu Ala Asp Ser Gln Asp 
    130                 135                 140                 


Leu Lys Leu Ser Thr Ile Ile Asp Met Leu Glu Gly Ala Phe Tyr Gly 
145                 150                 155                 160 


Leu Asp Leu Leu Lys Leu His Ser Val Thr Thr Lys Leu Val Gly Arg 
                165                 170                 175     


Val Asp Lys Leu Glu Glu Glu Val Ser Lys Asn Leu Thr Lys Glu Asn 
            180                 185                 190         


Glu Gln Ile Lys Glu Asp Met Glu Glu Ile Arg Thr Glu Met Asn Lys 
        195                 200                 205             


Arg Gly Lys Glu Asn Cys Ser Glu Asn Ile Leu Asp Ser Met Pro Asp 
    210                 215                 220                 


Ile Arg Ser Ala Leu Gln Arg Asp Ala Ala Ala Ala Tyr Ala His Pro 
225                 230                 235                 240 


Glu Gln Tyr Glu Glu Arg Phe Leu Gln Glu Glu Thr Val Ser Gln Gln 
                245                 250                 255     


Ile Asn Ser Ile Glu Leu Leu Gln Thr Arg Pro Leu Ala Leu Pro Glu 
            260                 265                 270         


Val Val Lys Ser Gln Arg Pro Leu Gln Arg Gln Val His Leu Arg Gly 
        275                 280                 285             


Arg Pro Ala Ser Gln Pro Thr Val Ile Arg Gly Ile Thr Tyr Tyr Lys 
    290                 295                 300                 


Ala Lys Val Ser Glu Glu Glu Asn Asp Ile Glu Glu Gln Gln Asp Glu 
305                 310                 315                 320 


Phe Phe Ser Gly Asp Asn Gly Val Asp Leu Leu Ile Glu Asp Gln Leu 
                325                 330                 335     


Leu Arg His Asn Gly Leu Met Thr Ser Val Thr Arg Arg Pro Ala Ala 
            340                 345                 350         


Thr Arg Gln Gly His Ser Thr Ala Val Thr Ser Asp Leu Asn Ala Arg 
        355                 360                 365             


Thr Ala Pro Trp Ser Ser Ala Leu Pro Gln Pro Ser Thr Ser Asp Pro 
    370                 375                 380                 


Ser Ile Ala Asn His Ala Ser Val Gly Pro Thr Leu Gln Thr Thr Ser 
385                 390                 395                 400 


Val Ser Pro Asp Pro Thr Arg Glu Ser Val Leu Gln Pro Ser Pro Gln 
                405                 410                 415     


Val Pro Ala Thr Thr Val Ala His Thr Ala Thr Gln Gln Pro Ala Ala 
            420                 425                 430         


Pro Ala Pro Pro Ala Val Ser Pro Arg Glu Ala Leu Met Glu Ala Met 
        435                 440                 445             


His Thr Val Pro Val Pro Pro Thr Thr Val Arg Thr Asp Ser Leu Gly 
    450                 455                 460                 


Lys Asp Ala Pro Ala Gly Trp Gly Thr Thr Pro Ala Ser Pro Thr Leu 
465                 470                 475                 480 


Ser Pro Glu Glu Glu Asp Asp Ile Arg Asn Val Ile Gly Arg Cys Lys 
                485                 490                 495     


Asp Thr Leu Ser Thr Ile Thr Gly Pro Thr Thr Gln Asn Thr Tyr Gly 
            500                 505                 510         


Arg Asn Glu Gly Ala Trp Met Lys Asp Pro Leu Ala Lys Asp Glu Arg 
        515                 520                 525             


Ile Tyr Val Thr Asn Tyr Tyr Tyr Gly Asn Thr Leu Val Glu Phe Arg 
    530                 535                 540                 


Asn Leu Glu Asn Phe Lys Gln Gly Arg Trp Ser Asn Ser Tyr Lys Leu 
545                 550                 555                 560 


Pro Tyr Ser Trp Ile Gly Thr Gly His Val Val Tyr Asn Gly Ala Phe 
                565                 570                 575     


Tyr Tyr Asn Arg Ala Phe Thr Arg Asn Ile Ile Lys Tyr Asp Leu Lys 
            580                 585                 590         


Gln Arg Tyr Val Ala Ala Trp Ala Met Leu His Asp Val Ala Tyr Glu 
        595                 600                 605             


Glu Ala Thr Pro Trp Arg Trp Gln Gly His Ser Asp Val Asp Phe Ala 
    610                 615                 620                 


Val Asp Glu Asn Gly Leu Trp Leu Ile Tyr Pro Ala Leu Asp Asp Glu 
625                 630                 635                 640 


Gly Phe Ser Gln Glu Val Ile Val Leu Ser Lys Leu Asn Ala Ala Asp 
                645                 650                 655     


Leu Ser Thr Gln Lys Glu Thr Thr Trp Arg Thr Gly Leu Arg Arg Asn 
            660                 665                 670         


Phe Tyr Gly Asn Cys Phe Val Ile Cys Gly Val Leu Tyr Ala Val Asp 
        675                 680                 685             


Ser Tyr Asn Gln Arg Asn Ala Asn Ile Ser Tyr Ala Phe Asp Thr His 
    690                 695                 700                 


Thr Asn Thr Gln Ile Val Pro Arg Leu Leu Phe Glu Asn Glu Tyr Ser 
705                 710                 715                 720 


Tyr Thr Thr Gln Ile Asp Tyr Asn Pro Lys Asp Arg Leu Leu Tyr Ala 
                725                 730                 735     


Trp Asp Asn Gly His Gln Val Thr Tyr His Val Ile Phe Ala Tyr 
            740                 745                 750     


<210>  9802
<211>  750
<212>  PRT
<213>  Homo Sapiens

<400>  9802

Met Ala Lys Pro Arg Leu Leu Val Leu Tyr Phe Ala Leu Ile Val Val 
1               5                   10                  15      


Pro Ala Trp Val Ser Ser Ile Val Leu Thr Gly Thr Ser Glu Pro Pro 
            20                  25                  30          


Asp Ala Gln Thr Val Ala Pro Ala Glu Asp Glu Thr Leu Gln Asn Glu 
        35                  40                  45              


Ala Asp Asn Gln Glu Asn Val Leu Ser Gln Leu Leu Gly Asp Tyr Asp 
    50                  55                  60                  


Lys Val Lys Ala Met Ser Glu Gly Ser Asp Cys Gln Cys Lys Cys Val 
65                  70                  75                  80  


Val Arg Pro Leu Gly Arg Asp Ala Cys Gln Arg Ile Asn Ala Gly Ala 
                85                  90                  95      


Ser Arg Lys Glu Asp Phe Tyr Thr Val Glu Thr Ile Thr Ser Gly Ser 
            100                 105                 110         


Ser Cys Lys Cys Ala Cys Val Ala Pro Pro Ser Ala Leu Asn Pro Cys 
        115                 120                 125             


Glu Gly Asp Phe Arg Leu Gln Lys Leu Arg Glu Ala Asp Ser Gln Asp 
    130                 135                 140                 


Leu Lys Leu Ser Thr Ile Ile Asp Met Leu Glu Gly Ala Phe Tyr Gly 
145                 150                 155                 160 


Leu Asp Leu Leu Lys Leu His Ser Val Thr Thr Lys Leu Val Gly Arg 
                165                 170                 175     


Val Asp Lys Leu Glu Glu Glu Val Ser Lys Asn Leu Thr Lys Glu Asn 
            180                 185                 190         


Glu Gln Ile Lys Glu Asp Met Glu Glu Ile Arg Thr Glu Met Asn Lys 
        195                 200                 205             


Arg Gly Lys Glu Asn Cys Ser Glu Asn Ile Leu Asp Ser Met Pro Asp 
    210                 215                 220                 


Ile Arg Ser Ala Leu Gln Arg Asp Ala Ala Ala Ala Tyr Ala His Pro 
225                 230                 235                 240 


Glu Tyr Glu Glu Arg Phe Leu Gln Glu Glu Thr Val Ser Gln Gln Ile 
                245                 250                 255     


Asn Ser Ile Glu Leu Leu Gln Thr Arg Pro Leu Ala Leu Pro Glu Val 
            260                 265                 270         


Val Lys Ser Gln Arg Pro Leu Gln Arg Gln Val His Leu Arg Gly Arg 
        275                 280                 285             


Pro Ala Ser Gln Pro Thr Val Ile Arg Gly Ile Thr Tyr Tyr Lys Ala 
    290                 295                 300                 


Lys Val Ser Glu Glu Glu Asn Asp Ile Glu Glu Gln Gln Asp Glu Phe 
305                 310                 315                 320 


Phe Ser Gly Asp Asn Gly Val Asp Leu Leu Ile Glu Asp Gln Leu Leu 
                325                 330                 335     


Arg His Asn Gly Leu Met Thr Ser Val Thr Arg Arg Pro Ala Ala Thr 
            340                 345                 350         


Arg Gln Gly His Ser Thr Ala Val Thr Ser Asp Leu Asn Ala Arg Thr 
        355                 360                 365             


Ala Pro Trp Ser Ser Ala Leu Pro Gln Pro Ser Thr Ser Asp Pro Ser 
    370                 375                 380                 


Ile Ala Asn His Ala Ser Val Gly Pro Thr Leu Gln Thr Thr Ser Val 
385                 390                 395                 400 


Ser Pro Asp Pro Thr Arg Glu Ser Val Leu Gln Pro Ser Pro Gln Val 
                405                 410                 415     


Pro Ala Thr Thr Val Ala His Thr Ala Thr Gln Gln Pro Ala Ala Pro 
            420                 425                 430         


Ala Pro Pro Ala Val Ser Pro Arg Glu Ala Leu Met Glu Ala Met His 
        435                 440                 445             


Thr Val Pro Val Pro Pro Thr Thr Val Arg Thr Asp Ser Leu Gly Lys 
    450                 455                 460                 


Asp Ala Pro Ala Gly Trp Gly Thr Thr Pro Ala Ser Pro Thr Leu Ser 
465                 470                 475                 480 


Pro Glu Glu Glu Asp Asp Ile Arg Asn Val Ile Gly Arg Cys Lys Asp 
                485                 490                 495     


Thr Leu Ser Thr Ile Thr Gly Pro Thr Thr Gln Asn Thr Tyr Gly Arg 
            500                 505                 510         


Asn Glu Gly Ala Trp Met Lys Asp Pro Leu Ala Lys Asp Glu Arg Ile 
        515                 520                 525             


Tyr Val Thr Asn Tyr Tyr Tyr Gly Asn Thr Leu Val Glu Phe Arg Asn 
    530                 535                 540                 


Leu Glu Asn Phe Lys Gln Gly Arg Trp Ser Asn Ser Tyr Lys Leu Pro 
545                 550                 555                 560 


Tyr Ser Trp Ile Gly Thr Gly His Val Val Tyr Asn Gly Ala Phe Tyr 
                565                 570                 575     


Tyr Asn Arg Ala Phe Thr Arg Asn Ile Ile Lys Tyr Asp Leu Lys Gln 
            580                 585                 590         


Arg Tyr Val Ala Ala Trp Ala Met Leu His Asp Val Ala Tyr Glu Glu 
        595                 600                 605             


Ala Thr Pro Trp Arg Trp Gln Gly His Ser Asp Val Asp Phe Ala Val 
    610                 615                 620                 


Asp Glu Asn Gly Leu Trp Leu Ile Tyr Pro Ala Leu Asp Asp Glu Gly 
625                 630                 635                 640 


Phe Ser Gln Glu Val Ile Val Leu Ser Lys Leu Asn Ala Ala Asp Leu 
                645                 650                 655     


Ser Thr Gln Lys Glu Thr Thr Trp Arg Thr Gly Leu Arg Arg Asn Phe 
            660                 665                 670         


Tyr Gly Asn Cys Phe Val Ile Cys Gly Val Leu Tyr Ala Val Asp Ser 
        675                 680                 685             


Tyr Asn Gln Arg Asn Ala Asn Ile Ser Tyr Ala Phe Asp Thr His Thr 
    690                 695                 700                 


Asn Thr Gln Ile Val Pro Arg Leu Leu Phe Glu Asn Glu Tyr Ser Tyr 
705                 710                 715                 720 


Thr Thr Gln Ile Asp Tyr Asn Pro Lys Asp Arg Leu Leu Tyr Ala Trp 
                725                 730                 735     


Asp Asn Gly His Gln Val Thr Tyr His Val Ile Phe Ala Tyr 
            740                 745                 750 


<210>  9803
<211>  233
<212>  PRT
<213>  Homo Sapiens

<400>  9803

Met Lys Asp Pro Leu Ala Lys Asp Glu Arg Ile Tyr Val Thr Asn Tyr 
1               5                   10                  15      


Tyr Tyr Gly Asn Thr Leu Val Glu Phe Arg Asn Leu Glu Asn Phe Lys 
            20                  25                  30          


Gln Gly Arg Trp Ser Asn Ser Tyr Lys Leu Pro Tyr Ser Trp Ile Gly 
        35                  40                  45              


Thr Gly His Val Val Tyr Asn Gly Ala Phe Tyr Tyr Asn Arg Ala Phe 
    50                  55                  60                  


Thr Arg Asn Ile Ile Lys Tyr Asp Leu Lys Gln Arg Tyr Val Ala Ala 
65                  70                  75                  80  


Trp Ala Met Leu His Asp Val Ala Tyr Glu Glu Ala Thr Pro Trp Arg 
                85                  90                  95      


Trp Gln Gly His Ser Asp Val Asp Phe Ala Val Asp Glu Asn Gly Leu 
            100                 105                 110         


Trp Leu Ile Tyr Pro Ala Leu Asp Asp Glu Gly Phe Ser Gln Glu Val 
        115                 120                 125             


Ile Val Leu Ser Lys Leu Asn Ala Ala Asp Leu Ser Thr Gln Lys Glu 
    130                 135                 140                 


Thr Thr Trp Arg Thr Gly Leu Arg Arg Asn Phe Tyr Gly Asn Cys Phe 
145                 150                 155                 160 


Val Ile Cys Gly Val Leu Tyr Ala Val Asp Ser Tyr Asn Gln Arg Asn 
                165                 170                 175     


Ala Asn Ile Ser Tyr Ala Phe Asp Thr His Thr Asn Thr Gln Ile Val 
            180                 185                 190         


Pro Arg Leu Leu Phe Glu Asn Glu Tyr Ser Tyr Thr Thr Gln Ile Asp 
        195                 200                 205             


Tyr Asn Pro Lys Asp Arg Leu Leu Tyr Ala Trp Asp Asn Gly His Gln 
    210                 215                 220                 


Val Thr Tyr His Val Ile Phe Ala Tyr 
225                 230             


<210>  9804
<211>  88
<212>  PRT
<213>  Homo Sapiens

<400>  9804

Thr Trp Arg Thr Gly Leu Arg Arg Asn Phe Tyr Gly Asn Cys Phe Val 
1               5                   10                  15      


Ile Cys Gly Val Leu Tyr Ala Val Asp Ser Tyr Asn Gln Arg Asn Ala 
            20                  25                  30          


Asn Ile Ser Tyr Ala Phe Asp Thr His Thr Asn Thr Gln Ile Val Pro 
        35                  40                  45              


Arg Leu Leu Phe Glu Asn Glu Tyr Ser Tyr Thr Thr Gln Ile Asp Tyr 
    50                  55                  60                  


Asn Pro Lys Asp Arg Leu Leu Tyr Ala Trp Asp Asn Gly His Gln Val 
65                  70                  75                  80  


Thr Tyr His Val Ile Phe Ala Tyr 
                85              


<210>  9805
<211>  386
<212>  PRT
<213>  Homo Sapiens

<400>  9805

Met Ala Gln Trp His Cys Ser Gln Arg Thr Gln Ala Gly Gly His Gly 
1               5                   10                  15      


Val Gly Glu Arg Leu Ala Gln Cys Gln Asp Gln Ser Ser Arg His Ala 
            20                  25                  30          


Ala Glu Leu Arg Asp Phe Lys Asn Lys Met Leu Pro Leu Leu Glu Val 
        35                  40                  45              


Ala Glu Lys Glu Arg Glu Ala Leu Arg Thr Glu Ala Asp Thr Ile Ser 
    50                  55                  60                  


Gly Arg Val Asp Arg Leu Glu Arg Glu Val Asp Tyr Leu Glu Thr Gln 
65                  70                  75                  80  


Asn Pro Ala Leu Pro Cys Val Glu Phe Asp Glu Lys Val Thr Gly Gly 
                85                  90                  95      


Pro Gly Thr Lys Gly Lys Gly Arg Arg Asn Glu Lys Tyr Asp Met Val 
            100                 105                 110         


Thr Asp Cys Gly Tyr Thr Ile Ser Gln Val Arg Ser Met Lys Ile Leu 
        115                 120                 125             


Lys Arg Phe Gly Gly Pro Ala Gly Leu Trp Thr Lys Asp Pro Leu Gly 
    130                 135                 140                 


Gln Thr Glu Lys Ile Tyr Val Leu Asp Gly Thr Gln Asn Asp Thr Ala 
145                 150                 155                 160 


Phe Val Phe Pro Arg Leu Arg Asp Phe Thr Leu Ala Met Ala Ala Arg 
                165                 170                 175     


Lys Ala Ser Arg Val Arg Val Pro Phe Pro Trp Val Gly Thr Gly Gln 
            180                 185                 190         


Leu Val Tyr Gly Gly Phe Leu Tyr Phe Ala Arg Arg Pro Pro Gly Arg 
        195                 200                 205             


Pro Gly Gly Gly Gly Glu Met Glu Asn Thr Leu Gln Leu Ile Lys Phe 
    210                 215                 220                 


His Leu Ala Asn Arg Thr Val Val Asp Ser Ser Val Phe Pro Ala Glu 
225                 230                 235                 240 


Gly Leu Ile Pro Pro Tyr Gly Leu Thr Ala Asp Thr Tyr Ile Asp Leu 
                245                 250                 255     


Ala Ala Asp Glu Glu Gly Leu Trp Ala Val Tyr Ala Thr Arg Glu Asp 
            260                 265                 270         


Asp Arg His Leu Cys Leu Ala Lys Leu Asp Pro Gln Thr Leu Asp Thr 
        275                 280                 285             


Glu Gln Gln Trp Asp Thr Pro Cys Pro Arg Glu Asn Ala Glu Ala Ala 
    290                 295                 300                 


Phe Val Ile Cys Gly Thr Leu Tyr Val Val Tyr Asn Thr Arg Pro Ala 
305                 310                 315                 320 


Ser Arg Ala Arg Ile Gln Cys Ser Phe Asp Ala Ser Gly Thr Leu Thr 
                325                 330                 335     


Pro Glu Arg Ala Ala Leu Pro Tyr Phe Pro Arg Arg Tyr Gly Ala His 
            340                 345                 350         


Ala Ser Leu Arg Tyr Asn Pro Arg Glu Arg Gln Leu Tyr Ala Trp Asp 
        355                 360                 365             


Asp Gly Tyr Gln Ile Val Tyr Lys Leu Glu Met Arg Lys Lys Glu Glu 
    370                 375                 380                 


Glu Val 
385     


<210>  9806
<211>  406
<212>  PRT
<213>  Homo Sapiens

<400>  9806

Met Gly Pro Ser Thr Pro Leu Leu Ile Leu Phe Leu Leu Ser Trp Ser 
1               5                   10                  15      


Gly Pro Leu Gln Gly Gln Gln His His Leu Val Glu Tyr Met Glu Arg 
            20                  25                  30          


Arg Leu Ala Ala Leu Glu Glu Arg Leu Ala Gln Cys Gln Asp Gln Ser 
        35                  40                  45              


Ser Arg His Ala Ala Glu Leu Arg Asp Phe Lys Asn Lys Met Leu Pro 
    50                  55                  60                  


Leu Leu Glu Val Ala Glu Lys Glu Arg Glu Ala Leu Arg Thr Glu Ala 
65                  70                  75                  80  


Asp Thr Ile Ser Gly Arg Val Asp Arg Leu Glu Arg Glu Val Asp Tyr 
                85                  90                  95      


Leu Glu Thr Gln Asn Pro Ala Leu Pro Cys Val Glu Phe Asp Glu Lys 
            100                 105                 110         


Val Thr Gly Gly Pro Gly Thr Lys Gly Lys Gly Arg Arg Asn Glu Lys 
        115                 120                 125             


Tyr Asp Met Val Thr Asp Cys Gly Tyr Thr Ile Ser Gln Val Arg Ser 
    130                 135                 140                 


Met Lys Ile Leu Lys Arg Phe Gly Gly Pro Ala Gly Leu Trp Thr Lys 
145                 150                 155                 160 


Asp Pro Leu Gly Gln Thr Glu Lys Ile Tyr Val Leu Asp Gly Thr Gln 
                165                 170                 175     


Asn Asp Thr Ala Phe Val Phe Pro Arg Leu Arg Asp Phe Thr Leu Ala 
            180                 185                 190         


Met Ala Ala Arg Lys Ala Ser Arg Val Arg Val Pro Phe Pro Trp Val 
        195                 200                 205             


Gly Thr Gly Gln Leu Val Tyr Gly Gly Phe Leu Tyr Phe Ala Arg Arg 
    210                 215                 220                 


Pro Pro Gly Arg Pro Gly Gly Gly Gly Glu Met Glu Asn Thr Leu Gln 
225                 230                 235                 240 


Leu Ile Lys Phe His Leu Ala Asn Arg Thr Val Val Asp Ser Ser Val 
                245                 250                 255     


Phe Pro Ala Glu Gly Leu Ile Pro Pro Tyr Gly Leu Thr Ala Asp Thr 
            260                 265                 270         


Tyr Ile Asp Leu Ala Ala Asp Glu Glu Gly Leu Trp Ala Val Tyr Ala 
        275                 280                 285             


Thr Arg Glu Asp Asp Arg His Leu Cys Leu Ala Lys Leu Asp Pro Gln 
    290                 295                 300                 


Thr Leu Asp Thr Glu Gln Gln Trp Asp Thr Pro Cys Pro Arg Glu Asn 
305                 310                 315                 320 


Ala Glu Ala Ala Phe Val Ile Cys Gly Thr Leu Tyr Val Val Tyr Asn 
                325                 330                 335     


Thr Arg Pro Ala Ser Arg Ala Arg Ile Gln Cys Ser Phe Asp Ala Ser 
            340                 345                 350         


Gly Thr Leu Thr Pro Glu Arg Ala Ala Leu Pro Tyr Phe Pro Arg Arg 
        355                 360                 365             


Tyr Gly Ala His Ala Ser Leu Arg Tyr Asn Pro Arg Glu Arg Gln Leu 
    370                 375                 380                 


Tyr Ala Trp Asp Asp Gly Tyr Gln Ile Val Tyr Lys Leu Glu Met Arg 
385                 390                 395                 400 


Lys Lys Glu Glu Glu Val 
                405     


<210>  9807
<211>  345
<212>  PRT
<213>  Homo Sapiens

<400>  9807

Met Leu Pro Leu Leu Glu Val Ala Glu Lys Glu Arg Glu Ala Leu Arg 
1               5                   10                  15      


Thr Glu Ala Asp Thr Ile Ser Gly Arg Val Asp Arg Leu Glu Arg Glu 
            20                  25                  30          


Val Asp Tyr Leu Glu Thr Gln Asn Pro Ala Leu Pro Cys Val Glu Phe 
        35                  40                  45              


Asp Glu Lys Val Thr Gly Gly Pro Gly Thr Lys Gly Lys Gly Arg Arg 
    50                  55                  60                  


Asn Glu Lys Tyr Asp Met Val Thr Asp Cys Gly Tyr Thr Ile Ser Gln 
65                  70                  75                  80  


Val Arg Ser Met Lys Ile Leu Lys Arg Phe Gly Gly Pro Ala Gly Leu 
                85                  90                  95      


Trp Thr Lys Asp Pro Leu Gly Gln Thr Glu Lys Ile Tyr Val Leu Asp 
            100                 105                 110         


Gly Thr Gln Asn Asp Thr Ala Phe Val Phe Pro Arg Leu Arg Asp Phe 
        115                 120                 125             


Thr Leu Ala Met Ala Ala Arg Lys Ala Ser Arg Val Arg Val Pro Phe 
    130                 135                 140                 


Pro Trp Val Gly Thr Gly Gln Leu Val Tyr Gly Gly Phe Leu Tyr Phe 
145                 150                 155                 160 


Ala Arg Arg Pro Pro Gly Arg Pro Gly Gly Gly Gly Glu Met Glu Asn 
                165                 170                 175     


Thr Leu Gln Leu Ile Lys Phe His Leu Ala Asn Arg Thr Val Val Asp 
            180                 185                 190         


Ser Ser Val Phe Pro Ala Glu Gly Leu Ile Pro Pro Tyr Gly Leu Thr 
        195                 200                 205             


Ala Asp Thr Tyr Ile Asp Leu Ala Ala Asp Glu Glu Gly Leu Trp Ala 
    210                 215                 220                 


Val Tyr Ala Thr Arg Glu Asp Asp Arg His Leu Cys Leu Ala Lys Leu 
225                 230                 235                 240 


Asp Pro Gln Thr Leu Asp Thr Glu Gln Gln Trp Asp Thr Pro Cys Pro 
                245                 250                 255     


Arg Glu Asn Ala Glu Ala Ala Phe Val Ile Cys Gly Thr Leu Tyr Val 
            260                 265                 270         


Val Tyr Asn Thr Arg Pro Ala Ser Arg Ala Arg Ile Gln Cys Ser Phe 
        275                 280                 285             


Asp Ala Ser Gly Thr Leu Thr Pro Glu Arg Ala Ala Leu Pro Tyr Phe 
    290                 295                 300                 


Pro Arg Arg Tyr Gly Ala His Ala Ser Leu Arg Tyr Asn Pro Arg Glu 
305                 310                 315                 320 


Arg Gln Leu Tyr Ala Trp Asp Asp Gly Tyr Gln Ile Val Tyr Lys Leu 
                325                 330                 335     


Glu Met Arg Lys Lys Glu Glu Glu Val 
            340                 345 


<210>  9808
<211>  421
<212>  PRT
<213>  Homo Sapiens

<400>  9808

Met Gly Phe Leu Ser Pro Ile Tyr Val Ile Phe Phe Phe Phe Gly Val 
1               5                   10                  15      


Lys Val His Cys Gln Tyr Glu Thr Tyr Gln Trp Asp Glu Asp Tyr Asp 
            20                  25                  30          


Gln Glu Pro Asp Asp Asp Tyr Gln Thr Gly Phe Pro Phe Arg Gln Asn 
        35                  40                  45              


Val Asp Tyr Gly Val Pro Phe His Gln Tyr Thr Leu Gly Cys Val Ser 
    50                  55                  60                  


Glu Cys Phe Cys Pro Thr Asn Phe Pro Ser Ser Met Tyr Cys Asp Asn 
65                  70                  75                  80  


Arg Lys Leu Lys Thr Ile Pro Asn Ile Pro Met His Ile Gln Gln Leu 
                85                  90                  95      


Tyr Leu Gln Phe Asn Glu Ile Glu Ala Val Thr Ala Asn Ser Phe Ile 
            100                 105                 110         


Asn Ala Thr His Leu Lys Glu Ile Asn Leu Ser His Asn Lys Ile Lys 
        115                 120                 125             


Ser Gln Lys Ile Asp Tyr Gly Val Phe Ala Lys Leu Pro Asn Leu Leu 
    130                 135                 140                 


Gln Leu His Leu Glu His Asn Asn Leu Glu Glu Phe Pro Phe Pro Leu 
145                 150                 155                 160 


Pro Lys Ser Leu Glu Arg Leu Leu Leu Gly Tyr Asn Glu Ile Ser Lys 
                165                 170                 175     


Leu Gln Thr Asn Ala Met Asp Gly Leu Val Asn Leu Thr Met Leu Asp 
            180                 185                 190         


Leu Cys Tyr Asn Tyr Leu His Asp Ser Leu Leu Lys Asp Lys Ile Phe 
        195                 200                 205             


Ala Lys Met Glu Lys Leu Met Gln Leu Asn Leu Cys Ser Asn Arg Leu 
    210                 215                 220                 


Glu Ser Met Pro Pro Gly Leu Pro Ser Ser Leu Met Tyr Leu Ser Leu 
225                 230                 235                 240 


Glu Asn Asn Ser Ile Ser Ser Ile Pro Glu Lys Tyr Phe Asp Lys Leu 
                245                 250                 255     


Pro Lys Leu His Thr Leu Arg Met Ser His Asn Lys Leu Gln Asp Ile 
            260                 265                 270         


Pro Tyr Asn Ile Phe Asn Leu Pro Asn Ile Val Glu Leu Ser Val Gly 
        275                 280                 285             


His Asn Lys Leu Lys Gln Ala Phe Tyr Ile Pro Arg Asn Leu Glu His 
    290                 295                 300                 


Leu Tyr Leu Gln Asn Asn Glu Ile Glu Lys Met Asn Leu Thr Val Met 
305                 310                 315                 320 


Cys Pro Ser Ile Asp Pro Leu His Tyr His His Leu Thr Tyr Ile Arg 
                325                 330                 335     


Val Asp Gln Asn Lys Leu Lys Glu Pro Ile Ser Ser Tyr Ile Phe Phe 
            340                 345                 350         


Cys Phe Pro His Ile His Thr Ile Tyr Tyr Gly Glu Gln Arg Ser Thr 
        355                 360                 365             


Asn Gly Gln Thr Ile Gln Leu Lys Thr Gln Val Phe Arg Arg Phe Pro 
    370                 375                 380                 


Asp Asp Asp Asp Glu Ser Glu Asp His Asp Asp Pro Asp Asn Ala His 
385                 390                 395                 400 


Glu Ser Pro Glu Gln Glu Gly Ala Glu Gly His Phe Asp Leu His Tyr 
                405                 410                 415     


Tyr Glu Asn Gln Glu 
            420     


<210>  9809
<211>  440
<212>  PRT
<213>  Homo Sapiens

<400>  9809

Met Glu Tyr Gln Ile Leu Lys Met Ser Leu Cys Leu Phe Ile Leu Leu 
1               5                   10                  15      


Phe Leu Thr Pro Gly Ile Leu Cys Ile Cys Pro Leu Gln Cys Ile Cys 
            20                  25                  30          


Thr Glu Arg His Arg His Val Asp Cys Ser Gly Arg Asn Leu Ser Thr 
        35                  40                  45              


Leu Pro Ser Gly Leu Gln Glu Asn Ile Ile His Leu Asn Leu Ser Tyr 
    50                  55                  60                  


Asn His Phe Thr Asp Leu His Asn Gln Leu Thr Gln Tyr Thr Asn Leu 
65                  70                  75                  80  


Arg Thr Leu Asp Ile Ser Asn Asn Arg Leu Glu Ser Leu Pro Ala His 
                85                  90                  95      


Leu Pro Arg Ser Leu Trp Asn Met Ser Ala Ala Asn Asn Asn Ile Lys 
            100                 105                 110         


Leu Leu Asp Lys Ser Asp Thr Ala Tyr Gln Trp Asn Leu Lys Tyr Leu 
        115                 120                 125             


Asp Val Ser Lys Asn Met Leu Glu Lys Val Val Leu Ile Lys Asn Thr 
    130                 135                 140                 


Leu Arg Ser Leu Glu Val Leu Asn Leu Ser Ser Asn Lys Leu Trp Thr 
145                 150                 155                 160 


Val Pro Thr Asn Met Pro Ser Lys Leu His Ile Val Asp Leu Ser Asn 
                165                 170                 175     


Asn Ser Leu Thr Gln Ile Leu Pro Gly Thr Leu Ile Asn Leu Thr Asn 
            180                 185                 190         


Leu Thr His Leu Tyr Leu His Asn Asn Lys Phe Thr Phe Ile Pro Asp 
        195                 200                 205             


Gln Ser Phe Asp Gln Leu Phe Gln Leu Gln Glu Ile Thr Leu Tyr Asn 
    210                 215                 220                 


Asn Arg Trp Ser Cys Asp His Lys Gln Asn Ile Thr Tyr Leu Leu Lys 
225                 230                 235                 240 


Trp Met Met Glu Thr Lys Ala His Val Ile Gly Thr Pro Cys Ser Thr 
                245                 250                 255     


Gln Ile Ser Ser Leu Lys Glu His Asn Met Tyr Pro Thr Pro Ser Gly 
            260                 265                 270         


Phe Thr Ser Ser Leu Phe Thr Val Ser Gly Met Gln Thr Val Asp Thr 
        275                 280                 285             


Ile Asn Ser Leu Ser Val Val Thr Gln Pro Lys Val Thr Lys Ile Pro 
    290                 295                 300                 


Lys Gln Tyr Arg Thr Lys Glu Thr Thr Phe Gly Ala Thr Leu Ser Lys 
305                 310                 315                 320 


Asp Thr Thr Phe Thr Ser Thr Asp Lys Ala Phe Val Pro Tyr Pro Glu 
                325                 330                 335     


Asp Thr Ser Thr Glu Thr Ile Asn Ser His Glu Ala Ala Ala Ala Thr 
            340                 345                 350         


Leu Thr Ile His Leu Gln Asp Gly Met Val Thr Asn Thr Ser Leu Thr 
        355                 360                 365             


Ser Ser Thr Lys Ser Ser Pro Thr Pro Met Thr Leu Ser Ile Thr Ser 
    370                 375                 380                 


Gly Met Pro Asn Asn Phe Ser Glu Met Pro Gln Gln Ser Thr Thr Leu 
385                 390                 395                 400 


Asn Leu Trp Arg Glu Glu Thr Thr Thr Asn Val Lys Thr Pro Leu Pro 
                405                 410                 415     


Ser Val Ala Asn Ala Trp Lys Val Asn Ala Ser Phe Leu Leu Leu Leu 
            420                 425                 430         


Asn Val Val Val Met Leu Ala Val 
        435                 440 


<210>  9810
<211>  158
<212>  PRT
<213>  Homo Sapiens

<400>  9810

Met Ala Leu Glu Val Leu Met Leu Leu Ala Val Leu Ile Trp Thr Gly 
1               5                   10                  15      


Ala Glu Asn Leu His Val Lys Ile Ser Cys Ser Leu Asp Trp Leu Met 
            20                  25                  30          


Val Ser Val Ile Pro Val Ala Glu Ser Arg Asn Leu Tyr Ile Phe Ala 
        35                  40                  45              


Asp Glu Leu His Leu Gly Met Gly Cys Pro Ala Asn Arg Ile His Thr 
    50                  55                  60                  


Tyr Val Tyr Glu Phe Ile Tyr Leu Val Arg Asp Cys Gly Ile Arg Thr 
65                  70                  75                  80  


Arg Val Val Ser Glu Glu Thr Leu Leu Phe Gln Thr Glu Leu Tyr Phe 
                85                  90                  95      


Thr Pro Arg Asn Ile Asp His Asp Pro Gln Glu Ile His Leu Glu Cys 
            100                 105                 110         


Ser Thr Ser Arg Lys Ser Val Trp Leu Thr Pro Val Ser Thr Glu Asn 
        115                 120                 125             


Glu Ile Lys Leu Asp Pro Ser Pro Phe Ile Ala Asp Phe Gln Thr Thr 
    130                 135                 140                 


Ala Glu Glu Leu Gly Leu Leu Ser Ser Ser Pro Asn Leu Leu 
145                 150                 155             


<210>  9811
<211>  86
<212>  PRT
<213>  Homo Sapiens

<400>  9811

Met Val Ser Val Ile Pro Val Ala Glu Ser Arg Asn Leu Tyr Ile Phe 
1               5                   10                  15      


Ala Asp Glu Leu His Leu Gly Met Gly Cys Pro Ala Asn Arg Ile His 
            20                  25                  30          


Thr Tyr Val Tyr Glu Phe Ile Tyr Leu Val Arg Asp Cys Gly Ile Arg 
        35                  40                  45              


Thr Arg Val Val Ser Glu Glu Thr Leu Leu Phe Gln Thr Glu Leu Tyr 
    50                  55                  60                  


Phe Thr Pro Arg Asn Ile Asp His Asp Pro Gln Glu Ile His Leu Glu 
65                  70                  75                  80  


Cys Ser Thr Ser Ser Val 
                85      


<210>  9812
<211>  304
<212>  PRT
<213>  Homo Sapiens

<400>  9812

Met Asp Asn Val Thr Val Arg Gln Gly Glu Ser Ala Thr Leu Arg Cys 
1               5                   10                  15      


Thr Ile Asp Asp Arg Val Thr Arg Val Ala Trp Leu Asn Arg Ser Thr 
            20                  25                  30          


Ile Leu Tyr Ala Gly Asn Asp Lys Trp Ser Ile Asp Pro Arg Val Ile 
        35                  40                  45              


Ile Leu Val Asn Thr Pro Thr Gln Tyr Ser Ile Met Ile Gln Asn Val 
    50                  55                  60                  


Asp Val Tyr Asp Glu Gly Pro Tyr Thr Cys Ser Val Gln Thr Asp Asn 
65                  70                  75                  80  


His Pro Lys Thr Ser Arg Val His Leu Ile Val Gln Val Pro Pro Gln 
                85                  90                  95      


Ile Met Asn Ile Ser Ser Asp Ile Thr Val Asn Glu Gly Ser Ser Val 
            100                 105                 110         


Thr Leu Leu Cys Leu Ala Ile Gly Arg Pro Glu Pro Thr Val Thr Trp 
        115                 120                 125             


Arg His Leu Ser Val Lys Glu Gly Gln Gly Phe Val Ser Glu Asp Glu 
    130                 135                 140                 


Tyr Leu Glu Ile Ser Asp Ile Lys Arg Asp Gln Ser Gly Glu Tyr Glu 
145                 150                 155                 160 


Cys Ser Ala Leu Asn Asp Val Ala Ala Pro Asp Val Arg Lys Val Lys 
                165                 170                 175     


Ile Thr Val Asn Tyr Pro Pro Tyr Ile Ser Lys Ala Lys Asn Thr Gly 
            180                 185                 190         


Val Ser Val Gly Gln Lys Gly Ile Leu Ser Cys Glu Ala Ser Ala Val 
        195                 200                 205             


Pro Met Ala Glu Phe Gln Trp Phe Lys Glu Glu Thr Arg Leu Ala Thr 
    210                 215                 220                 


Gly Leu Asp Gly Met Arg Ile Glu Asn Lys Gly Arg Met Ser Thr Leu 
225                 230                 235                 240 


Thr Phe Phe Asn Val Ser Glu Lys Asp Tyr Gly Asn Tyr Thr Cys Val 
                245                 250                 255     


Ala Thr Asn Lys Leu Gly Asn Thr Asn Ala Ser Ile Thr Leu Tyr Gly 
            260                 265                 270         


Pro Gly Ala Val Ile Asp Gly Val Asn Ser Ala Ser Arg Ala Leu Ala 
        275                 280                 285             


Cys Leu Trp Leu Ser Gly Thr Leu Leu Ala His Phe Phe Ile Lys Phe 
    290                 295                 300                 


<210>  9813
<211>  345
<212>  PRT
<213>  Homo Sapiens

<400>  9813

Met Gly Val Cys Gly Tyr Leu Phe Leu Pro Trp Lys Cys Leu Val Val 
1               5                   10                  15      


Val Ser Leu Arg Leu Leu Phe Leu Val Pro Thr Gly Val Pro Val Arg 
            20                  25                  30          


Ser Gly Asp Ala Thr Phe Pro Lys Ala Met Asp Asn Val Thr Val Arg 
        35                  40                  45              


Gln Gly Glu Ser Ala Thr Leu Arg Cys Thr Ile Asp Asp Arg Val Thr 
    50                  55                  60                  


Arg Val Ala Trp Leu Asn Arg Ser Thr Ile Leu Tyr Ala Gly Asn Asp 
65                  70                  75                  80  


Lys Trp Ser Ile Asp Pro Arg Val Ile Ile Leu Val Asn Thr Pro Thr 
                85                  90                  95      


Gln Tyr Ser Ile Met Ile Gln Asn Val Asp Val Tyr Asp Glu Gly Pro 
            100                 105                 110         


Tyr Thr Cys Ser Val Gln Thr Asp Asn His Pro Lys Thr Ser Arg Val 
        115                 120                 125             


His Leu Ile Val Gln Val Pro Pro Gln Ile Met Asn Ile Ser Ser Asp 
    130                 135                 140                 


Ile Thr Val Asn Glu Gly Ser Ser Val Thr Leu Leu Cys Leu Ala Ile 
145                 150                 155                 160 


Gly Arg Pro Glu Pro Thr Val Thr Trp Arg His Leu Ser Val Lys Glu 
                165                 170                 175     


Gly Gln Gly Phe Val Ser Glu Asp Glu Tyr Leu Glu Ile Ser Asp Ile 
            180                 185                 190         


Lys Arg Asp Gln Ser Gly Glu Tyr Glu Cys Ser Ala Leu Asn Asp Val 
        195                 200                 205             


Ala Ala Pro Asp Val Arg Lys Val Lys Ile Thr Val Asn Tyr Pro Pro 
    210                 215                 220                 


Tyr Ile Ser Lys Ala Lys Asn Thr Gly Val Ser Val Gly Gln Lys Gly 
225                 230                 235                 240 


Ile Leu Ser Cys Glu Ala Ser Ala Val Pro Met Ala Glu Phe Gln Trp 
                245                 250                 255     


Phe Lys Glu Glu Thr Arg Leu Ala Thr Gly Leu Asp Gly Met Arg Ile 
            260                 265                 270         


Glu Asn Lys Gly Arg Met Ser Thr Leu Thr Phe Phe Asn Val Ser Glu 
        275                 280                 285             


Lys Asp Tyr Gly Asn Tyr Thr Cys Val Ala Thr Asn Lys Leu Gly Asn 
    290                 295                 300                 


Thr Asn Ala Ser Ile Thr Leu Tyr Gly Pro Gly Ala Val Ile Asp Gly 
305                 310                 315                 320 


Val Asn Ser Ala Ser Arg Ala Leu Ala Cys Leu Trp Leu Ser Gly Thr 
                325                 330                 335     


Leu Leu Ala His Phe Phe Ile Lys Phe 
            340                 345 


<210>  9814
<211>  354
<212>  PRT
<213>  Homo Sapiens

<400>  9814

Met Gly Val Cys Gly Tyr Leu Phe Leu Pro Trp Lys Cys Leu Val Val 
1               5                   10                  15      


Val Ser Leu Arg Leu Leu Phe Leu Val Pro Thr Gly Val Pro Val Arg 
            20                  25                  30          


Ser Gly Asp Ala Thr Phe Pro Lys Ala Met Asp Asn Val Thr Val Arg 
        35                  40                  45              


Gln Gly Glu Ser Ala Thr Leu Arg Cys Thr Ile Asp Asp Arg Val Thr 
    50                  55                  60                  


Arg Val Ala Trp Leu Asn Arg Ser Thr Ile Leu Tyr Ala Gly Asn Asp 
65                  70                  75                  80  


Lys Trp Ser Ile Asp Pro Arg Val Ile Ile Leu Val Asn Thr Pro Thr 
                85                  90                  95      


Gln Tyr Ser Ile Met Ile Gln Asn Val Asp Val Tyr Asp Glu Gly Pro 
            100                 105                 110         


Tyr Thr Cys Ser Val Gln Thr Asp Asn His Pro Lys Thr Ser Arg Val 
        115                 120                 125             


His Leu Ile Val Gln Val Pro Pro Gln Ile Met Asn Ile Ser Ser Asp 
    130                 135                 140                 


Ile Thr Val Asn Glu Gly Ser Ser Val Thr Leu Leu Cys Leu Ala Ile 
145                 150                 155                 160 


Gly Arg Pro Glu Pro Thr Val Thr Trp Arg His Leu Ser Val Lys Glu 
                165                 170                 175     


Gly Gln Gly Phe Val Ser Glu Asp Glu Tyr Leu Glu Ile Ser Asp Ile 
            180                 185                 190         


Lys Arg Asp Gln Ser Gly Glu Tyr Glu Cys Ser Ala Leu Asn Asp Val 
        195                 200                 205             


Ala Ala Pro Asp Val Arg Lys Val Lys Ile Thr Val Asn Tyr Pro Pro 
    210                 215                 220                 


Tyr Ile Ser Lys Ala Lys Asn Thr Gly Val Ser Val Gly Gln Lys Gly 
225                 230                 235                 240 


Ile Leu Ser Cys Glu Ala Ser Ala Val Pro Met Ala Glu Phe Gln Trp 
                245                 250                 255     


Phe Lys Glu Glu Thr Arg Leu Ala Thr Gly Leu Asp Gly Met Arg Ile 
            260                 265                 270         


Glu Asn Lys Gly Arg Met Ser Thr Leu Thr Phe Phe Asn Val Ser Glu 
        275                 280                 285             


Lys Asp Tyr Gly Asn Tyr Thr Cys Val Ala Thr Asn Lys Leu Gly Asn 
    290                 295                 300                 


Thr Asn Ala Ser Ile Thr Leu Tyr Glu Ile Ser Pro Ser Ser Ala Val 
305                 310                 315                 320 


Ala Gly Pro Gly Ala Val Ile Asp Gly Val Asn Ser Ala Ser Arg Ala 
                325                 330                 335     


Leu Ala Cys Leu Trp Leu Ser Gly Thr Leu Leu Ala His Phe Phe Ile 
            340                 345                 350         


Lys Phe 
        


<210>  9815
<211>  345
<212>  PRT
<213>  Homo Sapiens

<400>  9815

Met Gly Val Cys Gly Tyr Leu Phe Leu Pro Trp Lys Cys Leu Val Val 
1               5                   10                  15      


Val Ser Leu Arg Leu Leu Phe Leu Val Pro Thr Gly Val Pro Val Arg 
            20                  25                  30          


Ser Gly Asp Ala Thr Phe Pro Lys Ala Met Asp Asn Val Thr Val Arg 
        35                  40                  45              


Gln Gly Glu Ser Ala Thr Leu Arg Cys Thr Ile Asp Asp Arg Val Thr 
    50                  55                  60                  


Arg Val Ala Trp Leu Asn Arg Ser Thr Ile Leu Tyr Ala Gly Asn Asp 
65                  70                  75                  80  


Lys Trp Ser Ile Asp Pro Arg Val Ile Ile Leu Val Asn Thr Pro Thr 
                85                  90                  95      


Gln Tyr Ser Ile Met Ile Gln Asn Val Asp Val Tyr Asp Glu Gly Pro 
            100                 105                 110         


Tyr Thr Cys Ser Val Gln Thr Asp Asn His Pro Lys Thr Ser Arg Val 
        115                 120                 125             


His Leu Ile Val Gln Val Pro Pro Gln Ile Met Asn Ile Ser Ser Asp 
    130                 135                 140                 


Ile Thr Val Asn Glu Gly Ser Ser Val Thr Leu Leu Cys Leu Ala Ile 
145                 150                 155                 160 


Gly Arg Pro Glu Pro Thr Val Thr Trp Arg His Leu Ser Val Lys Glu 
                165                 170                 175     


Gly Gln Gly Phe Val Ser Glu Asp Glu Tyr Leu Glu Ile Ser Asp Ile 
            180                 185                 190         


Lys Arg Asp Gln Ser Gly Glu Tyr Glu Cys Ser Ala Leu Asn Asp Val 
        195                 200                 205             


Ala Ala Pro Asp Val Arg Lys Val Lys Ile Thr Val Asn Tyr Pro Pro 
    210                 215                 220                 


Tyr Ile Ser Lys Ala Lys Asn Thr Gly Val Ser Val Gly Gln Lys Gly 
225                 230                 235                 240 


Ile Leu Ser Cys Glu Ala Ser Ala Val Pro Met Ala Glu Phe Gln Trp 
                245                 250                 255     


Phe Lys Glu Glu Thr Arg Leu Ala Thr Gly Leu Asp Gly Met Arg Ile 
            260                 265                 270         


Glu Asn Lys Gly Arg Met Ser Thr Leu Thr Phe Phe Asn Val Ser Glu 
        275                 280                 285             


Lys Asp Tyr Gly Asn Tyr Thr Cys Val Ala Thr Asn Lys Leu Gly Asn 
    290                 295                 300                 


Thr Asn Ala Ser Ile Thr Leu Tyr Gly Pro Gly Ala Val Ile Asp Gly 
305                 310                 315                 320 


Val Asn Ser Ala Ser Arg Ala Leu Ala Cys Leu Trp Leu Ser Gly Thr 
                325                 330                 335     


Leu Leu Ala His Phe Phe Ile Lys Phe 
            340                 345 


<210>  9816
<211>  338
<212>  PRT
<213>  Homo Sapiens

<400>  9816

Met Tyr His Pro Ala Tyr Trp Val Val Phe Ser Ala Thr Thr Ala Leu 
1               5                   10                  15      


Leu Phe Ile Pro Gly Val Pro Val Arg Ser Gly Asp Ala Thr Phe Pro 
            20                  25                  30          


Lys Ala Met Asp Asn Val Thr Val Arg Gln Gly Glu Ser Ala Thr Leu 
        35                  40                  45              


Arg Cys Thr Ile Asp Asp Arg Val Thr Arg Val Ala Trp Leu Asn Arg 
    50                  55                  60                  


Ser Thr Ile Leu Tyr Ala Gly Asn Asp Lys Trp Ser Ile Asp Pro Arg 
65                  70                  75                  80  


Val Ile Ile Leu Val Asn Thr Pro Thr Gln Tyr Ser Ile Met Ile Gln 
                85                  90                  95      


Asn Val Asp Val Tyr Asp Glu Gly Pro Tyr Thr Cys Ser Val Gln Thr 
            100                 105                 110         


Asp Asn His Pro Lys Thr Ser Arg Val His Leu Ile Val Gln Val Pro 
        115                 120                 125             


Pro Gln Ile Met Asn Ile Ser Ser Asp Ile Thr Val Asn Glu Gly Ser 
    130                 135                 140                 


Ser Val Thr Leu Leu Cys Leu Ala Ile Gly Arg Pro Glu Pro Thr Val 
145                 150                 155                 160 


Thr Trp Arg His Leu Ser Val Lys Glu Gly Gln Gly Phe Val Ser Glu 
                165                 170                 175     


Asp Glu Tyr Leu Glu Ile Ser Asp Ile Lys Arg Asp Gln Ser Gly Glu 
            180                 185                 190         


Tyr Glu Cys Ser Ala Leu Asn Asp Val Ala Ala Pro Asp Val Arg Lys 
        195                 200                 205             


Val Lys Ile Thr Val Asn Tyr Pro Pro Tyr Ile Ser Lys Ala Lys Asn 
    210                 215                 220                 


Thr Gly Val Ser Val Gly Gln Lys Gly Ile Leu Ser Cys Glu Ala Ser 
225                 230                 235                 240 


Ala Val Pro Met Ala Glu Phe Gln Trp Phe Lys Glu Glu Thr Arg Leu 
                245                 250                 255     


Ala Thr Gly Leu Asp Gly Met Arg Ile Glu Asn Lys Gly Arg Met Ser 
            260                 265                 270         


Thr Leu Thr Phe Phe Asn Val Ser Glu Lys Asp Tyr Gly Asn Tyr Thr 
        275                 280                 285             


Cys Val Ala Thr Asn Lys Leu Gly Asn Thr Asn Ala Ser Ile Thr Leu 
    290                 295                 300                 


Tyr Gly Pro Gly Ala Val Ile Asp Gly Val Asn Ser Ala Ser Arg Ala 
305                 310                 315                 320 


Leu Ala Cys Leu Trp Leu Ser Gly Thr Leu Leu Ala His Phe Phe Ile 
                325                 330                 335     


Lys Phe 
        


<210>  9817
<211>  248
<212>  PRT
<213>  Homo Sapiens

<400>  9817

Met Lys Leu Thr Phe Phe Leu Gly Leu Leu Ala Leu Ile Ser Cys Phe 
1               5                   10                  15      


Thr Pro Ser Glu Ser Gln Arg Phe Ser Arg Arg Pro Tyr Leu Pro Gly 
            20                  25                  30          


Gln Leu Pro Pro Pro Pro Leu Tyr Arg Pro Arg Trp Val Pro Pro Ser 
        35                  40                  45              


Pro Pro Pro Pro Tyr Asp Ser Arg Leu Asn Ser Pro Leu Ser Leu Pro 
    50                  55                  60                  


Phe Val Pro Gly Arg Val Pro Pro Ser Ser Phe Ser Arg Phe Ser Gln 
65                  70                  75                  80  


Ala Val Ile Leu Ser Gln Leu Phe Pro Leu Glu Ser Ile Arg Gln Pro 
                85                  90                  95      


Arg Leu Phe Pro Gly Tyr Pro Asn Leu His Phe Pro Leu Arg Pro Tyr 
            100                 105                 110         


Tyr Val Gly Pro Ile Arg Ile Leu Lys Pro Pro Phe Pro Pro Ile Pro 
        115                 120                 125             


Phe Phe Leu Ala Ile Tyr Leu Pro Ile Ser Asn Pro Glu Pro Gln Ile 
    130                 135                 140                 


Asn Ile Thr Thr Ala Asp Thr Thr Ile Thr Thr Asn Pro Pro Thr Thr 
145                 150                 155                 160 


Ala Thr Ala Thr Thr Ser Thr Ser Thr Lys Pro Thr Met Thr Ile Ser 
                165                 170                 175     


Ser Ser Thr Val Pro Ile Ser Ser Thr Pro Glu Pro Ala Thr Ser Ile 
            180                 185                 190         


Ser Ala Ala Thr Pro Ala Ala Ser Thr Glu Asn Thr Thr Gln Ile Leu 
        195                 200                 205             


Ala Asn Arg Pro His Thr Val Leu Leu Asn Ala Thr Val Gln Val Thr 
    210                 215                 220                 


Thr Ser Asn Gln Thr Ile Leu Ser Ser Pro Ala Phe Lys Ser Phe Trp 
225                 230                 235                 240 


Gln Lys Leu Phe Ala Ile Phe Gly 
                245             


<210>  9818
<211>  174
<212>  PRT
<213>  Homo Sapiens

<400>  9818

Met Arg Leu Leu Ala Phe Leu Ser Leu Leu Ala Leu Val Leu Gln Glu 
1               5                   10                  15      


Thr Gly Thr Ala Ser Leu Pro Arg Lys Glu Arg Lys Arg Arg Glu Glu 
            20                  25                  30          


Gln Met Pro Arg Glu Gly Asp Ser Phe Glu Val Leu Pro Leu Arg Asn 
        35                  40                  45              


Asp Val Leu Asn Pro Asp Asn Tyr Gly Glu Val Ile Asp Leu Ser Asn 
    50                  55                  60                  


Tyr Glu Glu Leu Thr Asp Tyr Gly Asp Gln Leu Pro Glu Val Lys Val 
65                  70                  75                  80  


Thr Ser Leu Ala Pro Ala Thr Ser Ile Ser Pro Ala Lys Ser Thr Thr 
                85                  90                  95      


Ala Pro Gly Thr Pro Ser Ser Asn Pro Thr Met Thr Arg Pro Thr Thr 
            100                 105                 110         


Ala Gly Leu Leu Leu Ser Ser Gln Pro Asn His Glu Asp Ile Pro Pro 
        115                 120                 125             


Leu Pro Arg Arg Thr Ala Tyr Leu Tyr Ala Arg Phe Asn Arg Ile Ser 
    130                 135                 140                 


Arg Ile Arg Ala Glu Asp Phe Lys Gly Leu Thr Lys Leu Lys Arg Ile 
145                 150                 155                 160 


Asp Leu Ser Asn Asn Leu Ile Ser Ser Ile Asp Asn Asp Ala 
                165                 170                 


<210>  9819
<211>  332
<212>  PRT
<213>  Homo Sapiens

<400>  9819

Met Arg Leu Leu Ala Phe Leu Ser Leu Leu Ala Leu Val Leu Gln Glu 
1               5                   10                  15      


Thr Gly Thr Ala Ser Leu Pro Arg Lys Glu Arg Lys Arg Arg Glu Glu 
            20                  25                  30          


Gln Met Pro Arg Glu Gly Asp Ser Phe Glu Val Leu Pro Leu Arg Asn 
        35                  40                  45              


Asp Val Leu Asn Pro Asp Asn Tyr Gly Glu Val Ile Asp Leu Ser Asn 
    50                  55                  60                  


Tyr Glu Glu Leu Thr Asp Tyr Gly Asp Gln Leu Pro Glu Val Lys Val 
65                  70                  75                  80  


Thr Ser Leu Ala Pro Ala Thr Ser Ile Ser Pro Ala Lys Ser Thr Thr 
                85                  90                  95      


Ala Pro Gly Thr Pro Ser Ser Asn Pro Thr Met Thr Arg Pro Thr Thr 
            100                 105                 110         


Ala Gly Leu Leu Leu Ser Ser Gln Pro Asn His Gly Leu Pro Thr Cys 
        115                 120                 125             


Leu Val Cys Val Cys Leu Gly Ser Ser Val Tyr Cys Asp Asp Ile Asp 
    130                 135                 140                 


Leu Glu Asp Ile Pro Pro Leu Pro Arg Arg Thr Ala Tyr Leu Tyr Ala 
145                 150                 155                 160 


Arg Phe Asn Arg Ile Ser Arg Ile Arg Ala Glu Asp Phe Lys Gly Leu 
                165                 170                 175     


Thr Lys Leu Lys Arg Ile Asp Leu Ser Asn Asn Leu Ile Ser Ser Ile 
            180                 185                 190         


Asp Asn Asp Ala Phe Arg Leu Leu His Ala Leu Gln Asp Leu Ile Leu 
        195                 200                 205             


Pro Glu Asn Gln Leu Glu Ala Leu Pro Val Leu Pro Ser Gly Ile Glu 
    210                 215                 220                 


Phe Leu Asp Val Arg Leu Asn Arg Leu Gln Ser Ser Gly Ile Gln Pro 
225                 230                 235                 240 


Ala Ala Phe Arg Ala Met Glu Lys Leu Gln Phe Leu Tyr Leu Ser Asp 
                245                 250                 255     


Asn Leu Leu Asp Ser Ile Pro Gly Pro Leu Pro Leu Ser Leu Arg Ser 
            260                 265                 270         


Val His Leu Gln Asn Asn Leu Ile Glu Thr Met Gln Arg Asp Val Phe 
        275                 280                 285             


Cys Asp Pro Glu Glu His Lys His Thr Arg Arg Gln Leu Glu Asp Ile 
    290                 295                 300                 


Arg Leu Asp Gly Asn Pro Ile Asn Leu Ser Leu Phe Pro Ser Ala Tyr 
305                 310                 315                 320 


Phe Cys Leu Pro Arg Leu Pro Ile Gly Arg Phe Thr 
                325                 330         


<210>  9820
<211>  301
<212>  PRT
<213>  Homo Sapiens

<400>  9820

Met His Pro Glu Pro Ala Pro Pro Pro Ser Arg Ser Ser Pro Glu Leu 
1               5                   10                  15      


Pro Pro Ser Gly Gly Ser Thr Thr Ser Gly Ser Arg Arg Ser Arg Arg 
            20                  25                  30          


Arg Ser Gly Asp Gly Glu Pro Pro Gly Ala Pro Pro Pro Pro Pro Ser 
        35                  40                  45              


Ala Val Thr Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu Val Met 
    50                  55                  60                  


Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys Leu Tyr 
65                  70                  75                  80  


Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu Leu 
                85                  90                  95      


Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp Ala Asp 
            100                 105                 110         


His Asp Tyr Pro Pro Gly Leu Leu Ile Ala Phe Ser Ala Cys Thr Thr 
        115                 120                 125             


Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr Cys Ile 
    130                 135                 140                 


Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn Ser Val 
145                 150                 155                 160 


Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu Ala Trp 
                165                 170                 175     


Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu Val Val 
            180                 185                 190         


Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Lys Gln Pro Gly Gln 
        195                 200                 205             


Pro Arg Pro Thr Ser Lys Pro Pro Ala Ser Gly Ala Ala Ala Asn Val 
    210                 215                 220                 


Ser Thr Ser Gly Ile Thr Pro Gly Gln Ala Ala Ala Ile Ala Ser Thr 
225                 230                 235                 240 


Thr Ile Met Val Pro Phe Gly Leu Ile Phe Ile Val Phe Ala Val His 
                245                 250                 255     


Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe Gln Glu 
            260                 265                 270         


Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu Asp His 
        275                 280                 285             


Arg Gly Asp His Pro Leu Thr Pro Gly Ser His Tyr Ala 
    290                 295                 300     


<210>  9821
<211>  201
<212>  PRT
<213>  Homo Sapiens

<400>  9821

Met Ala Leu Ser Trp Val Leu Thr Val Leu Ser Leu Leu Pro Leu Leu 
1               5                   10                  15      


Glu Ala Gln Ile Pro Leu Cys Ala Asn Leu Val Pro Val Pro Ile Thr 
            20                  25                  30          


Asn Ala Thr Leu Asp Arg Ile Thr Gly Lys Trp Phe Tyr Ile Ala Ser 
        35                  40                  45              


Ala Phe Arg Asn Glu Glu Tyr Asn Lys Ser Val Gln Glu Ile Gln Ala 
    50                  55                  60                  


Thr Phe Phe Tyr Phe Thr Pro Asn Lys Thr Glu Asp Thr Ile Phe Leu 
65                  70                  75                  80  


Arg Glu Tyr Gln Thr Arg Gln Asp Gln Cys Ile Tyr Asn Thr Thr Tyr 
                85                  90                  95      


Leu Asn Val Gln Arg Glu Asn Gly Thr Ile Ser Arg Tyr Val Gly Gly 
            100                 105                 110         


Gln Glu His Phe Ala His Leu Leu Ile Leu Arg Asp Thr Lys Thr Tyr 
        115                 120                 125             


Met Leu Ala Phe Asp Val Asn Asp Glu Lys Asn Trp Gly Leu Ser Val 
    130                 135                 140                 


Tyr Ala Asp Lys Pro Glu Thr Thr Lys Glu Gln Leu Gly Glu Phe Tyr 
145                 150                 155                 160 


Glu Ala Leu Asp Cys Leu Arg Ile Pro Lys Ser Asp Val Val Tyr Thr 
                165                 170                 175     


Asp Trp Lys Lys Asp Lys Cys Glu Pro Leu Glu Lys Gln His Glu Lys 
            180                 185                 190         


Glu Arg Lys Gln Glu Glu Gly Glu Ser 
        195                 200     


<210>  9822
<211>  201
<212>  PRT
<213>  Homo Sapiens

<400>  9822

Met Ala Leu Ser Trp Val Leu Thr Val Leu Ser Leu Leu Pro Leu Leu 
1               5                   10                  15      


Glu Ala Gln Ile Pro Leu Cys Ala Asn Leu Val Pro Val Pro Ile Thr 
            20                  25                  30          


Asn Ala Thr Leu Asp Arg Ile Thr Gly Lys Trp Phe Tyr Ile Ala Ser 
        35                  40                  45              


Ala Phe Arg Asn Glu Glu Tyr Asn Lys Ser Val Gln Glu Ile Gln Ala 
    50                  55                  60                  


Thr Phe Phe Tyr Phe Thr Pro Asn Lys Thr Glu Asp Thr Ile Phe Leu 
65                  70                  75                  80  


Arg Glu Tyr Gln Thr Arg Gln Asn Gln Cys Phe Tyr Asn Ser Ser Tyr 
                85                  90                  95      


Leu Asn Val Gln Arg Glu Asn Gly Thr Val Ser Arg Tyr Glu Gly Gly 
            100                 105                 110         


Arg Glu His Val Ala His Leu Leu Phe Leu Arg Asp Thr Lys Thr Leu 
        115                 120                 125             


Met Phe Gly Ser Tyr Leu Asp Asp Glu Lys Asn Trp Gly Leu Ser Phe 
    130                 135                 140                 


Tyr Ala Asp Lys Pro Glu Thr Thr Lys Glu Gln Leu Gly Glu Phe Tyr 
145                 150                 155                 160 


Glu Ala Leu Asp Cys Leu Cys Ile Pro Arg Ser Asp Val Met Tyr Thr 
                165                 170                 175     


Asp Trp Lys Lys Asp Lys Cys Glu Pro Leu Glu Lys Gln His Glu Lys 
            180                 185                 190         


Glu Arg Lys Gln Glu Glu Gly Glu Ser 
        195                 200     


<210>  9823
<211>  65
<212>  PRT
<213>  Homo Sapiens

<400>  9823

Met Asp Tyr Gly Leu Gln Phe Thr Ser Ser Arg Lys Phe Leu Ser Ile 
1               5                   10                  15      


Ser Pro Ile Val Leu Tyr Leu Leu Ala Ser Phe Tyr Thr Lys Tyr Asp 
            20                  25                  30          


Ala Ala His Phe Leu Ile Asn Thr Ala Ser Leu Leu Ser Val Leu Leu 
        35                  40                  45              


Pro Lys Leu Pro Gln Phe His Gly Val Arg Val Phe Gly Ile Asn Lys 
    50                  55                  60                  


Tyr 
65  


<210>  9824
<211>  153
<212>  PRT
<213>  Homo Sapiens

<400>  9824

Met Asn Val Gly Val Ala His Ser Glu Val Asn Pro Asn Thr Arg Val 
1               5                   10                  15      


Met Asn Ser Arg Gly Ile Trp Leu Ala Tyr Ile Ile Leu Val Gly Leu 
            20                  25                  30          


Leu His Met Val Leu Leu Ser Ile Pro Phe Phe Ser Ile Pro Val Val 
        35                  40                  45              


Trp Thr Leu Thr Asn Val Ile His Asn Leu Ala Thr Tyr Val Phe Leu 
    50                  55                  60                  


His Thr Val Lys Gly Thr Pro Phe Glu Thr Pro Asp Gln Gly Lys Ala 
65                  70                  75                  80  


Arg Leu Leu Thr His Trp Glu Gln Met Asp Tyr Gly Leu Gln Phe Thr 
                85                  90                  95      


Ser Ser Arg Lys Phe Leu Ser Ile Ser Pro Ile Val Leu Tyr Leu Leu 
            100                 105                 110         


Ala Ser Phe Tyr Thr Lys Tyr Asp Ala Ala His Phe Leu Ile Asn Thr 
        115                 120                 125             


Ala Ser Leu Leu Ser Val Leu Leu Pro Lys Leu Pro Gln Phe His Gly 
    130                 135                 140                 


Val Arg Val Phe Gly Ile Asn Lys Tyr 
145                 150             


<210>  9825
<211>  153
<212>  PRT
<213>  Homo Sapiens

<400>  9825

Met Asn Val Gly Val Ala His Ser Glu Val Asn Pro Asn Thr Arg Val 
1               5                   10                  15      


Met Asn Ser Arg Gly Ile Trp Leu Ala Tyr Ile Ile Leu Val Gly Leu 
            20                  25                  30          


Leu His Met Val Leu Leu Ser Ile Pro Phe Phe Ser Ile Pro Val Val 
        35                  40                  45              


Trp Thr Leu Thr Asn Val Ile His Asn Leu Ala Thr Tyr Val Phe Leu 
    50                  55                  60                  


His Thr Val Lys Gly Thr Pro Phe Glu Thr Pro Asp Gln Gly Lys Ala 
65                  70                  75                  80  


Arg Leu Leu Thr His Trp Glu Gln Met Asp Tyr Gly Leu Gln Phe Thr 
                85                  90                  95      


Ser Ser Arg Lys Phe Leu Ser Ile Ser Pro Ile Val Leu Tyr Leu Leu 
            100                 105                 110         


Ala Ser Phe Tyr Thr Lys Tyr Asp Ala Ala His Phe Leu Ile Asn Thr 
        115                 120                 125             


Ala Ser Leu Leu Ser Val Leu Leu Pro Lys Leu Pro Gln Phe His Gly 
    130                 135                 140                 


Val Arg Val Phe Gly Ile Asn Lys Tyr 
145                 150             


<210>  9826
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  9826

Met Val Leu Leu Ser Ile Pro Phe Phe Ser Ile Pro Val Val Trp Thr 
1               5                   10                  15      


Leu Thr Asn Val Ile His Asn Leu Ala Thr Tyr Val Phe Leu His Thr 
            20                  25                  30          


Val Lys Gly Thr Pro Phe Glu Thr Pro Asp Gln Gly Lys Ala Arg Leu 
        35                  40                  45              


Leu Thr His Trp Glu Gln Met Asp Tyr Gly Leu Gln Phe Thr Ser Ser 
    50                  55                  60                  


Arg Lys Phe Leu Ser Ile Ser Pro Ile Val Leu Tyr Leu Leu Ala Ser 
65                  70                  75                  80  


Phe Tyr Thr Lys Tyr Asp Ala Ala His Phe Leu Ile Asn Thr Ala Ser 
                85                  90                  95      


Leu Leu Ser Val Leu Leu Pro Lys Leu Pro Gln Phe His Gly Val Arg 
            100                 105                 110         


Val Phe Gly Ile Asn Lys Tyr 
        115                 


<210>  9827
<211>  75
<212>  PRT
<213>  Homo Sapiens

<400>  9827

Met Ala Ala Glu Thr Leu Leu Ser Ser Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Pro Ala Ser Leu Thr Gly Gly Val Gly Ser Leu Asn 
            20                  25                  30          


Leu Glu Glu Leu Ser Glu Met Arg Tyr Gly Ile Glu Ile Leu Pro Leu 
        35                  40                  45              


Pro Val Met Gly Gly Gln Pro Phe Phe Ala Ser Leu Pro Pro Asp Pro 
    50                  55                  60                  


Pro Phe Phe Pro Arg Ala Asn Leu Arg Thr Trp 
65                  70                  75  


<210>  9828
<211>  75
<212>  PRT
<213>  Homo Sapiens

<400>  9828

Met Ala Ala Glu Thr Leu Leu Ser Ser Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Pro Ala Ser Leu Thr Gly Gly Val Gly Ser Leu Asn 
            20                  25                  30          


Leu Glu Glu Leu Ser Glu Met Arg Tyr Gly Ile Glu Ile Leu Pro Leu 
        35                  40                  45              


Pro Val Met Gly Gly Gln Pro Phe Phe Ala Ser Leu Pro Pro Asp Pro 
    50                  55                  60                  


Pro Phe Phe Pro Arg Ala Asn Leu Arg Thr Trp 
65                  70                  75  


<210>  9829
<211>  125
<212>  PRT
<213>  Homo Sapiens

<400>  9829

Met Ala Ala Glu Thr Leu Leu Ser Ser Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Pro Ala Ser Leu Thr Gly Gly Val Gly Ser Leu Asn 
            20                  25                  30          


Leu Glu Glu Leu Ser Glu Met Arg Tyr Gly Ile Glu Ile Leu Pro Leu 
        35                  40                  45              


Pro Val Met Gly Gly Gln Ser Gln Ser Ser Asp Val Val Ile Val Ser 
    50                  55                  60                  


Ser Lys Tyr Lys Gln Arg Tyr Glu Cys Arg Leu Pro Ala Gly Ala Ile 
65                  70                  75                  80  


His Phe Gln Arg Glu Arg Glu Glu Glu Thr Pro Ala Tyr Gln Gly Pro 
                85                  90                  95      


Gly Ile Pro Glu Leu Leu Ser Pro Met Arg Asp Ala Pro Cys Leu Leu 
            100                 105                 110         


Lys Gly Gly Met Glu Arg Pro Gln Val Glu Asn Arg Leu 
        115                 120                 125 


<210>  9830
<211>  406
<212>  PRT
<213>  Homo Sapiens

<400>  9830

Met Ala Ala Glu Thr Leu Leu Ser Ser Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Pro Ala Ser Leu Thr Gly Gly Val Gly Ser Leu Asn 
            20                  25                  30          


Leu Glu Glu Leu Ser Glu Met Arg Tyr Gly Ile Glu Ile Leu Pro Leu 
        35                  40                  45              


Pro Val Met Gly Gly Gln Ser Gln Ser Ser Asp Val Val Ile Val Ser 
    50                  55                  60                  


Ser Lys Tyr Lys Gln Arg Tyr Glu Cys Arg Leu Pro Ala Gly Ala Ile 
65                  70                  75                  80  


His Phe Gln Arg Glu Arg Glu Glu Glu Thr Pro Ala Tyr Gln Gly Pro 
                85                  90                  95      


Gly Ile Pro Glu Leu Leu Ser Pro Met Arg Asp Ala Pro Cys Leu Leu 
            100                 105                 110         


Lys Thr Lys Asp Trp Trp Thr Tyr Glu Phe Cys Tyr Gly Arg His Ile 
        115                 120                 125             


Gln Gln Tyr His Met Glu Asp Ser Ala Ser Gly Ala Pro Asn Asp Phe 
    130                 135                 140                 


Gln Asn Asn Val Gln Val Lys Val Ile Arg Ser Pro Ala Asp Leu Ile 
145                 150                 155                 160 


Arg Phe Ile Glu Glu Leu Lys Gly Gly Thr Lys Lys Gly Lys Pro Asn 
                165                 170                 175     


Ile Gly Gln Glu Gln Pro Val Asp Asp Ala Ala Glu Val Pro Gln Arg 
            180                 185                 190         


Glu Pro Glu Lys Glu Arg Gly Asp Pro Glu Arg Gln Arg Glu Met Glu 
        195                 200                 205             


Glu Glu Glu Asp Glu Asp Glu Asp Glu Asp Glu Asp Glu Asp Glu Arg 
    210                 215                 220                 


Gln Leu Leu Gly Glu Phe Glu Lys Glu Leu Glu Gly Ile Leu Leu Pro 
225                 230                 235                 240 


Ser Asp Arg Asp Arg Leu Arg Ser Glu Val Lys Ala Gly Met Glu Arg 
                245                 250                 255     


Glu Leu Glu Asn Ile Ile Gln Glu Thr Glu Lys Glu Leu Asp Pro Asp 
            260                 265                 270         


Gly Leu Lys Lys Glu Ser Glu Arg Asp Arg Ala Met Leu Ala Leu Thr 
        275                 280                 285             


Ser Thr Leu Asn Lys Leu Ile Lys Arg Leu Glu Glu Lys Gln Ser Pro 
    290                 295                 300                 


Glu Leu Val Lys Lys His Lys Lys Lys Arg Val Val Pro Lys Lys Pro 
305                 310                 315                 320 


Pro Pro Ser Pro Gln Pro Thr Gly Lys Ile Glu Ile Lys Ile Val Arg 
                325                 330                 335     


Pro Trp Ala Glu Gly Thr Glu Glu Gly Ala Arg Trp Leu Thr Asp Glu 
            340                 345                 350         


Asp Thr Arg Asn Leu Lys Glu Ile Phe Phe Asn Ile Leu Val Pro Gly 
        355                 360                 365             


Ala Glu Glu Ala Gln Lys Glu Arg Gln Arg Gln Lys Glu Leu Glu Ser 
    370                 375                 380                 


Asn Tyr Arg Arg Val Trp Gly Ser Pro Gly Gly Glu Gly Thr Gly Asp 
385                 390                 395                 400 


Leu Asp Glu Phe Asp Phe 
                405     


<210>  9831
<211>  560
<212>  PRT
<213>  Homo Sapiens

<400>  9831

Met Ala Ala Glu Thr Leu Leu Ser Ser Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Pro Ala Ser Leu Thr Gly Gly Val Gly Ser Leu Asn 
            20                  25                  30          


Leu Glu Glu Leu Ser Glu Met Arg Tyr Gly Ile Glu Ile Leu Pro Leu 
        35                  40                  45              


Pro Val Met Gly Gly Gln Ser Gln Ser Ser Asp Val Val Ile Val Ser 
    50                  55                  60                  


Ser Lys Tyr Lys Gln Arg Tyr Glu Cys Arg Leu Pro Ala Gly Ala Ile 
65                  70                  75                  80  


His Phe Gln Arg Glu Arg Glu Glu Glu Thr Pro Ala Tyr Gln Gly Pro 
                85                  90                  95      


Gly Ile Pro Glu Leu Leu Ser Pro Met Arg Asp Ala Pro Cys Leu Leu 
            100                 105                 110         


Lys Thr Lys Asp Trp Trp Thr Tyr Glu Phe Cys Tyr Gly Arg His Ile 
        115                 120                 125             


Gln Gln Tyr His Met Glu Asp Ser Glu Ile Lys Gly Glu Phe Leu Cys 
    130                 135                 140                 


Asp Glu Gly Ala Gly Ile Ser Gly Asp Tyr Ile Asp Arg Val Asp Glu 
145                 150                 155                 160 


Pro Leu Ser Cys Ser Tyr Val Leu Thr Ile Arg Thr Pro Arg Leu Cys 
                165                 170                 175     


Pro His Pro Leu Leu Arg Pro Pro Pro Ser Ala Ala Pro Gln Ala Ile 
            180                 185                 190         


Leu Cys His Pro Ser Leu Gln Pro Glu Glu Tyr Met Ala Tyr Val Gln 
        195                 200                 205             


Arg Gln Ala Asp Ser Lys Gln Tyr Gly Asp Lys Ile Ile Glu Glu Leu 
    210                 215                 220                 


Gln Asp Leu Gly Pro Gln Val Trp Ser Glu Thr Lys Ser Gly Val Ala 
225                 230                 235                 240 


Pro Gln Lys Met Ala Gly Ala Ser Pro Thr Lys Asp Asp Ser Lys Asp 
                245                 250                 255     


Ser Asp Phe Trp Lys Met Leu Asn Glu Pro Glu Asp Gln Ala Pro Gly 
            260                 265                 270         


Gly Glu Glu Val Pro Ala Glu Glu Gln Asp Pro Ser Pro Glu Ala Ala 
        275                 280                 285             


Asp Ser Ala Ser Gly Ala Pro Asn Asp Phe Gln Asn Asn Val Gln Val 
    290                 295                 300                 


Lys Val Ile Arg Ser Pro Ala Asp Leu Ile Arg Phe Ile Glu Glu Leu 
305                 310                 315                 320 


Lys Gly Gly Thr Lys Lys Gly Lys Pro Asn Ile Gly Gln Glu Gln Pro 
                325                 330                 335     


Val Asp Asp Ala Ala Glu Val Pro Gln Arg Glu Pro Glu Lys Glu Arg 
            340                 345                 350         


Gly Asp Pro Glu Arg Gln Arg Glu Met Glu Glu Glu Glu Asp Glu Asp 
        355                 360                 365             


Glu Asp Glu Asp Glu Asp Glu Asp Glu Arg Gln Leu Leu Gly Glu Phe 
    370                 375                 380                 


Glu Lys Glu Leu Glu Gly Ile Leu Leu Pro Ser Asp Arg Asp Arg Leu 
385                 390                 395                 400 


Arg Ser Glu Val Lys Ala Gly Met Glu Arg Glu Leu Glu Asn Ile Ile 
                405                 410                 415     


Gln Glu Thr Glu Lys Glu Leu Asp Pro Asp Gly Leu Lys Lys Glu Ser 
            420                 425                 430         


Glu Arg Asp Arg Ala Met Leu Ala Leu Thr Ser Thr Leu Asn Lys Leu 
        435                 440                 445             


Ile Lys Arg Leu Glu Glu Lys Gln Ser Pro Glu Leu Val Lys Lys His 
    450                 455                 460                 


Lys Lys Lys Arg Val Val Pro Lys Lys Pro Pro Pro Ser Pro Gln Pro 
465                 470                 475                 480 


Thr Gly Lys Ile Glu Ile Lys Ile Val Arg Pro Trp Ala Glu Gly Thr 
                485                 490                 495     


Glu Glu Gly Ala Arg Trp Leu Thr Asp Glu Asp Thr Arg Asn Leu Lys 
            500                 505                 510         


Glu Ile Phe Phe Asn Ile Leu Val Pro Gly Ala Glu Glu Ala Gln Lys 
        515                 520                 525             


Glu Arg Gln Arg Gln Lys Glu Leu Glu Ser Asn Tyr Arg Arg Val Trp 
    530                 535                 540                 


Gly Ser Pro Gly Gly Glu Gly Thr Gly Asp Leu Asp Glu Phe Asp Phe 
545                 550                 555                 560 


<210>  9832
<211>  613
<212>  PRT
<213>  Homo Sapiens

<400>  9832

Met Ala Ala Glu Thr Leu Leu Ser Ser Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Pro Ala Ser Leu Thr Gly Gly Val Gly Ser Leu Asn 
            20                  25                  30          


Leu Glu Glu Leu Ser Glu Met Arg Tyr Gly Ile Glu Ile Leu Pro Leu 
        35                  40                  45              


Pro Val Met Gly Gly Gln Ser Gln Ser Ser Asp Val Val Ile Val Ser 
    50                  55                  60                  


Ser Lys Tyr Lys Gln Arg Tyr Glu Cys Arg Leu Pro Ala Gly Ala Ile 
65                  70                  75                  80  


His Phe Gln Arg Glu Arg Glu Glu Glu Thr Pro Ala Tyr Gln Gly Pro 
                85                  90                  95      


Gly Ile Pro Glu Leu Leu Ser Pro Met Arg Asp Ala Pro Cys Leu Leu 
            100                 105                 110         


Lys Thr Lys Asp Trp Trp Thr Tyr Glu Phe Cys Tyr Gly Arg His Ile 
        115                 120                 125             


Gln Gln Tyr His Met Glu Asp Ser Glu Ile Lys Gly Glu Val Leu Tyr 
    130                 135                 140                 


Leu Gly Tyr Tyr Gln Ser Ala Phe Asp Trp Asp Asp Glu Thr Ala Lys 
145                 150                 155                 160 


Ala Ser Lys Gln His Arg Leu Lys Arg Tyr His Ser Gln Thr Tyr Gly 
                165                 170                 175     


Asn Gly Ser Lys Cys Asp Leu Asn Gly Arg Pro Arg Glu Ala Glu Val 
            180                 185                 190         


Arg Phe Leu Cys Asp Glu Gly Ala Gly Ile Ser Gly Asp Tyr Ile Asp 
        195                 200                 205             


Arg Val Asp Glu Pro Leu Ser Cys Ser Tyr Val Leu Thr Ile Arg Thr 
    210                 215                 220                 


Pro Arg Leu Cys Pro His Pro Leu Leu Arg Pro Pro Pro Ser Ala Ala 
225                 230                 235                 240 


Pro Gln Ala Ile Leu Cys His Pro Ser Leu Gln Pro Glu Glu Tyr Met 
                245                 250                 255     


Ala Tyr Val Gln Arg Gln Ala Val Asp Ser Lys Gln Tyr Gly Asp Lys 
            260                 265                 270         


Ile Ile Glu Glu Leu Gln Asp Leu Gly Pro Gln Val Trp Ser Glu Thr 
        275                 280                 285             


Lys Ser Gly Val Ala Pro Gln Lys Met Ala Gly Ala Ser Pro Thr Lys 
    290                 295                 300                 


Asp Asp Ser Lys Asp Ser Asp Phe Trp Lys Met Leu Asn Glu Pro Glu 
305                 310                 315                 320 


Asp Gln Ala Pro Gly Gly Glu Glu Val Pro Ala Glu Glu Gln Asp Pro 
                325                 330                 335     


Ser Pro Glu Ala Ala Asp Ser Ala Ser Gly Ala Pro Asn Asp Phe Gln 
            340                 345                 350         


Asn Asn Val Gln Val Lys Val Ile Arg Ser Pro Ala Asp Leu Ile Arg 
        355                 360                 365             


Phe Ile Glu Glu Leu Lys Gly Gly Thr Lys Lys Gly Lys Pro Asn Ile 
    370                 375                 380                 


Gly Gln Glu Gln Pro Val Asp Asp Ala Ala Glu Val Pro Gln Arg Glu 
385                 390                 395                 400 


Pro Glu Lys Glu Arg Gly Asp Pro Glu Arg Gln Arg Glu Met Glu Glu 
                405                 410                 415     


Glu Glu Asp Glu Asp Glu Asp Glu Asp Glu Asp Glu Asp Glu Arg Gln 
            420                 425                 430         


Leu Leu Gly Glu Phe Glu Lys Glu Leu Glu Gly Ile Leu Leu Pro Ser 
        435                 440                 445             


Asp Arg Asp Arg Leu Arg Ser Glu Val Lys Ala Gly Met Glu Arg Glu 
    450                 455                 460                 


Leu Glu Asn Ile Ile Gln Glu Thr Glu Lys Glu Leu Asp Pro Asp Gly 
465                 470                 475                 480 


Leu Lys Lys Glu Ser Glu Arg Asp Arg Ala Met Leu Ala Leu Thr Ser 
                485                 490                 495     


Thr Leu Asn Lys Leu Ile Lys Arg Leu Glu Glu Lys Gln Ser Pro Glu 
            500                 505                 510         


Leu Val Lys Lys His Lys Lys Lys Arg Val Val Pro Lys Lys Pro Pro 
        515                 520                 525             


Pro Ser Pro Gln Pro Thr Gly Lys Ile Glu Ile Lys Ile Val Arg Pro 
    530                 535                 540                 


Trp Ala Glu Gly Thr Glu Glu Gly Ala Arg Trp Leu Thr Asp Glu Asp 
545                 550                 555                 560 


Thr Arg Asn Leu Lys Glu Ile Phe Phe Asn Ile Leu Val Pro Gly Ala 
                565                 570                 575     


Glu Glu Ala Gln Lys Glu Arg Gln Arg Gln Lys Glu Leu Glu Ser Asn 
            580                 585                 590         


Tyr Arg Arg Val Trp Gly Ser Pro Gly Gly Glu Gly Thr Gly Asp Leu 
        595                 600                 605             


Asp Glu Phe Asp Phe 
    610             


<210>  9833
<211>  667
<212>  PRT
<213>  Homo Sapiens

<400>  9833

Met Ala Ala Glu Thr Leu Leu Ser Ser Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Pro Ala Ser Leu Thr Gly Gly Val Gly Ser Leu Asn 
            20                  25                  30          


Leu Glu Glu Leu Ser Glu Met Arg Tyr Gly Ile Glu Ile Leu Pro Leu 
        35                  40                  45              


Pro Val Met Gly Gly Gln Ser Gln Ser Ser Asp Val Val Ile Val Ser 
    50                  55                  60                  


Ser Lys Tyr Lys Gln Arg Tyr Glu Cys Arg Leu Pro Ala Gly Ala Ile 
65                  70                  75                  80  


His Phe Gln Arg Glu Arg Glu Glu Glu Thr Pro Ala Tyr Gln Gly Pro 
                85                  90                  95      


Gly Ile Pro Glu Leu Leu Ser Pro Met Arg Asp Ala Pro Cys Leu Leu 
            100                 105                 110         


Lys Thr Lys Asp Trp Trp Thr Tyr Glu Phe Cys Tyr Gly Arg His Ile 
        115                 120                 125             


Gln Gln Tyr His Met Glu Asp Ser Glu Ile Lys Gly Glu Val Leu Tyr 
    130                 135                 140                 


Leu Gly Tyr Tyr Gln Ser Ala Phe Asp Trp Asp Asp Glu Thr Ala Lys 
145                 150                 155                 160 


Ala Ser Lys Gln His Arg Leu Lys Arg Tyr His Ser Gln Thr Tyr Gly 
                165                 170                 175     


Asn Gly Ser Lys Cys Asp Leu Asn Gly Arg Pro Arg Glu Ala Glu Val 
            180                 185                 190         


Arg Phe Leu Cys Asp Glu Gly Ala Gly Ile Ser Gly Asp Tyr Ile Asp 
        195                 200                 205             


Arg Val Asp Glu Pro Leu Ser Cys Ser Tyr Val Leu Thr Ile Arg Thr 
    210                 215                 220                 


Pro Arg Leu Cys Pro His Pro Leu Leu Arg Pro Pro Pro Ser Ala Ala 
225                 230                 235                 240 


Pro Gln Ala Ile Leu Cys His Pro Ser Leu Gln Pro Glu Glu Tyr Met 
                245                 250                 255     


Ala Tyr Val Gln Arg Gln Ala Asp Ser Lys Gln Tyr Gly Asp Lys Ile 
            260                 265                 270         


Ile Glu Glu Leu Gln Asp Leu Gly Pro Gln Val Trp Ser Glu Thr Lys 
        275                 280                 285             


Ser Gly Val Ala Pro Gln Lys Met Ala Gly Ala Ser Pro Thr Lys Asp 
    290                 295                 300                 


Asp Ser Lys Asp Ser Asp Phe Trp Lys Met Leu Asn Glu Pro Glu Asp 
305                 310                 315                 320 


Gln Ala Pro Gly Gly Glu Glu Val Pro Ala Glu Glu Gln Asp Pro Ser 
                325                 330                 335     


Pro Glu Ala Ala Asp Ser Ala Ser Gly Ala Pro Asn Asp Phe Gln Asn 
            340                 345                 350         


Asn Val Gln Val Lys Val Ile Arg Ser Pro Ala Asp Leu Ile Arg Phe 
        355                 360                 365             


Ile Glu Glu Leu Lys Gly Gly Thr Lys Lys Gly Lys Pro Asn Ile Gly 
    370                 375                 380                 


Gln Glu Gln Pro Val Asp Asp Ala Ala Glu Val Pro Gln Arg Glu Pro 
385                 390                 395                 400 


Glu Lys Glu Arg Gly Asp Pro Glu Arg Gln Arg Glu Met Glu Glu Glu 
                405                 410                 415     


Glu Asp Glu Asp Glu Asp Glu Asp Glu Asp Glu Asp Glu Arg Gln Leu 
            420                 425                 430         


Leu Gly Glu Phe Glu Lys Glu Leu Glu Gly Ile Leu Leu Pro Ser Asp 
        435                 440                 445             


Arg Asp Arg Leu Arg Ser Glu Val Lys Ala Gly Met Glu Arg Glu Leu 
    450                 455                 460                 


Glu Asn Ile Ile Gln Glu Thr Glu Lys Glu Leu Asp Pro Asp Gly Leu 
465                 470                 475                 480 


Lys Lys Glu Ser Glu Arg Asp Arg Ala Met Leu Ala Leu Thr Ser Thr 
                485                 490                 495     


Leu Asn Lys Leu Ile Lys Arg Leu Glu Glu Lys Gln Ser Pro Glu Leu 
            500                 505                 510         


Val Lys Lys His Lys Lys Lys Arg Val Val Pro Lys Lys Pro Pro Pro 
        515                 520                 525             


Ser Pro Gln Pro Thr Glu Glu Asp Pro Glu His Arg Val Arg Val Arg 
    530                 535                 540                 


Val Thr Lys Leu Arg Leu Gly Gly Pro Asn Gln Asp Leu Thr Val Leu 
545                 550                 555                 560 


Glu Met Lys Arg Glu Asn Pro Gln Leu Lys Gln Ile Glu Gly Leu Val 
                565                 570                 575     


Lys Glu Leu Leu Glu Arg Glu Gly Leu Thr Ala Ala Gly Lys Ile Glu 
            580                 585                 590         


Ile Lys Ile Val Arg Pro Trp Ala Glu Gly Thr Glu Glu Gly Ala Arg 
        595                 600                 605             


Trp Leu Thr Asp Glu Asp Thr Arg Asn Leu Lys Glu Ile Phe Phe Asn 
    610                 615                 620                 


Ile Leu Val Pro Gly Ala Glu Glu Ala Gln Lys Glu Arg Gln Arg Gln 
625                 630                 635                 640 


Lys Glu Leu Glu Ser Asn Tyr Arg Arg Val Trp Gly Ser Pro Gly Gly 
                645                 650                 655     


Glu Gly Thr Gly Asp Leu Asp Glu Phe Asp Phe 
            660                 665         


<210>  9834
<211>  597
<212>  PRT
<213>  Homo Sapiens

<400>  9834

Met Ala Ala Glu Thr Leu Leu Ser Ser Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Pro Ala Ser Leu Thr Gly Gly Val Gly Ser Leu Asn 
            20                  25                  30          


Leu Glu Glu Leu Ser Glu Met Arg Tyr Gly Ile Glu Ile Leu Pro Leu 
        35                  40                  45              


Pro Val Met Gly Gly Gln Ser Gln Ser Ser Asp Val Val Ile Val Ser 
    50                  55                  60                  


Ser Lys Tyr Lys Gln Arg Tyr Glu Cys Arg Leu Pro Ala Gly Ala Ile 
65                  70                  75                  80  


His Phe Gln Arg Glu Arg Glu Glu Glu Thr Pro Ala Tyr Gln Gly Pro 
                85                  90                  95      


Gly Ile Pro Glu Leu Leu Ser Pro Met Arg Asp Ala Pro Cys Leu Leu 
            100                 105                 110         


Lys Thr Lys Asp Trp Trp Thr Tyr Glu Phe Cys Tyr Gly Arg His Ile 
        115                 120                 125             


Gln Gln Tyr His Met Glu Asp Ser Glu Ile Lys Gly Glu Val Leu Tyr 
    130                 135                 140                 


Leu Gly Tyr Tyr Gln Ser Ala Phe Asp Trp Asp Asp Glu Thr Ala Lys 
145                 150                 155                 160 


Ala Ser Lys Gln His Arg Leu Lys Arg Tyr His Ser Gln Thr Tyr Gly 
                165                 170                 175     


Asn Gly Ser Lys Cys Asp Leu Asn Gly Arg Pro Arg Glu Ala Glu Val 
            180                 185                 190         


Arg Phe Leu Cys Asp Glu Gly Ala Gly Ile Ser Gly Asp Tyr Ile Asp 
        195                 200                 205             


Arg Val Asp Glu Pro Leu Ser Cys Ser Tyr Val Leu Thr Ile Arg Thr 
    210                 215                 220                 


Pro Arg Leu Cys Pro His Pro Leu Leu Arg Pro Pro Pro Ser Ala Ala 
225                 230                 235                 240 


Pro Gln Ala Ile Leu Cys His Pro Ser Leu Gln Pro Glu Glu Tyr Met 
                245                 250                 255     


Ala Tyr Val Gln Arg Gln Ala Asp Ser Lys Gln Tyr Gly Asp Lys Ile 
            260                 265                 270         


Ile Glu Glu Leu Gln Asp Leu Gly Pro Gln Val Trp Ser Glu Thr Lys 
        275                 280                 285             


Ser Gly Val Ala Pro Gln Lys Met Ala Gly Ala Ser Pro Thr Lys Asp 
    290                 295                 300                 


Asp Ser Lys Asp Ser Asp Phe Trp Lys Met Leu Asn Glu Pro Glu Asp 
305                 310                 315                 320 


Gln Ala Pro Gly Gly Glu Glu Val Pro Ala Glu Glu Gln Asp Pro Ser 
                325                 330                 335     


Pro Glu Ala Ala Asp Ser Ala Ser Gly Ala Pro Asn Asp Phe Gln Asn 
            340                 345                 350         


Asn Val Gln Val Lys Val Ile Arg Ser Pro Ala Asp Leu Ile Arg Phe 
        355                 360                 365             


Ile Glu Glu Leu Lys Gly Gly Thr Lys Lys Gly Lys Pro Asn Ile Gly 
    370                 375                 380                 


Gln Glu Gln Pro Val Asp Asp Ala Ala Glu Val Pro Gln Arg Glu Pro 
385                 390                 395                 400 


Glu Lys Glu Arg Gly Asp Pro Glu Arg Gln Arg Glu Met Glu Glu Glu 
                405                 410                 415     


Glu Asp Glu Asp Glu Asp Glu Asp Glu Asp Glu Asp Glu Arg Gln Leu 
            420                 425                 430         


Leu Gly Glu Phe Glu Lys Glu Leu Glu Gly Ile Leu Leu Pro Ser Asp 
        435                 440                 445             


Arg Asp Arg Leu Arg Ser Glu Thr Glu Lys Glu Leu Asp Pro Asp Gly 
    450                 455                 460                 


Leu Lys Lys Glu Ser Glu Arg Asp Arg Ala Met Leu Ala Leu Thr Ser 
465                 470                 475                 480 


Thr Leu Asn Lys Leu Ile Lys Arg Leu Glu Glu Lys Gln Ser Pro Glu 
                485                 490                 495     


Leu Val Lys Lys His Lys Lys Lys Arg Val Val Pro Lys Lys Pro Pro 
            500                 505                 510         


Pro Ser Pro Gln Pro Thr Gly Lys Ile Glu Ile Lys Ile Val Arg Pro 
        515                 520                 525             


Trp Ala Glu Gly Thr Glu Glu Gly Ala Arg Trp Leu Thr Asp Glu Asp 
    530                 535                 540                 


Thr Arg Asn Leu Lys Glu Ile Phe Phe Asn Ile Leu Val Pro Gly Ala 
545                 550                 555                 560 


Glu Glu Ala Gln Lys Glu Arg Gln Arg Gln Lys Glu Leu Glu Ser Asn 
                565                 570                 575     


Tyr Arg Arg Val Trp Gly Ser Pro Gly Gly Glu Gly Thr Gly Asp Leu 
            580                 585                 590         


Asp Glu Phe Asp Phe 
        595         


<210>  9835
<211>  652
<212>  PRT
<213>  Homo Sapiens

<400>  9835

Met Ala Ala Glu Thr Leu Leu Ser Ser Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Pro Ala Ser Leu Thr Gly Gly Val Gly Ser Leu Asn 
            20                  25                  30          


Leu Glu Glu Leu Ser Glu Met Arg Tyr Gly Ile Glu Ile Leu Pro Leu 
        35                  40                  45              


Pro Val Met Gly Gly Gln Ser Gln Ser Ser Asp Val Val Ile Val Ser 
    50                  55                  60                  


Ser Lys Tyr Lys Gln Arg Tyr Glu Cys Arg Leu Pro Ala Gly Ala Ile 
65                  70                  75                  80  


His Phe Gln Arg Glu Arg Glu Glu Glu Thr Pro Ala Tyr Gln Gly Pro 
                85                  90                  95      


Gly Ile Pro Glu Leu Leu Ser Pro Met Arg Asp Ala Pro Cys Leu Leu 
            100                 105                 110         


Lys Thr Lys Asp Trp Trp Thr Tyr Glu Phe Cys Tyr Gly Arg His Ile 
        115                 120                 125             


Gln Gln Tyr His Met Glu Asp Ser Glu Ile Lys Gly Glu Val Leu Tyr 
    130                 135                 140                 


Leu Gly Tyr Tyr Gln Ser Ala Phe Asp Trp Asp Asp Glu Thr Ala Lys 
145                 150                 155                 160 


Ala Ser Lys Gln His Arg Leu Lys Arg Tyr His Ser Gln Thr Tyr Gly 
                165                 170                 175     


Asn Gly Ser Lys Cys Asp Leu Asn Gly Arg Pro Arg Glu Ala Glu Val 
            180                 185                 190         


Arg Phe Leu Cys Asp Glu Gly Ala Gly Ile Ser Gly Asp Tyr Ile Asp 
        195                 200                 205             


Arg Val Asp Glu Pro Leu Ser Cys Ser Tyr Val Leu Thr Ile Arg Thr 
    210                 215                 220                 


Pro Arg Leu Cys Pro His Pro Leu Leu Arg Pro Pro Pro Ser Ala Ala 
225                 230                 235                 240 


Pro Gln Ala Ile Leu Cys His Pro Ser Leu Gln Pro Glu Glu Tyr Met 
                245                 250                 255     


Ala Tyr Val Gln Arg Gln Ala Asp Ser Lys Gln Tyr Gly Asp Lys Ile 
            260                 265                 270         


Ile Glu Glu Leu Gln Asp Leu Gly Pro Gln Val Trp Ser Glu Thr Lys 
        275                 280                 285             


Ser Gly Val Ala Pro Gln Lys Met Ala Gly Ala Ser Pro Thr Lys Asp 
    290                 295                 300                 


Asp Ser Lys Asp Ser Asp Phe Trp Lys Met Leu Asn Glu Pro Glu Asp 
305                 310                 315                 320 


Gln Ala Pro Gly Gly Glu Glu Val Pro Ala Glu Glu Gln Asp Pro Ser 
                325                 330                 335     


Pro Glu Ala Ala Asp Ser Ala Ser Gly Ala Pro Asn Asp Phe Gln Asn 
            340                 345                 350         


Asn Val Gln Val Lys Val Ile Arg Ser Pro Ala Asp Leu Ile Arg Phe 
        355                 360                 365             


Ile Glu Glu Leu Lys Gly Gly Thr Lys Lys Gly Lys Pro Asn Ile Gly 
    370                 375                 380                 


Gln Glu Gln Pro Val Asp Asp Ala Ala Glu Val Pro Gln Arg Glu Pro 
385                 390                 395                 400 


Glu Lys Glu Arg Gly Asp Pro Glu Arg Gln Arg Glu Met Glu Glu Glu 
                405                 410                 415     


Glu Asp Glu Asp Glu Asp Glu Asp Glu Asp Glu Asp Glu Arg Gln Leu 
            420                 425                 430         


Leu Gly Glu Phe Glu Lys Glu Leu Glu Gly Ile Leu Leu Pro Ser Asp 
        435                 440                 445             


Arg Asp Arg Leu Arg Ser Glu Thr Glu Lys Glu Leu Asp Pro Asp Gly 
    450                 455                 460                 


Leu Lys Lys Glu Ser Glu Arg Asp Arg Ala Met Leu Ala Leu Thr Ser 
465                 470                 475                 480 


Thr Leu Asn Lys Leu Ile Lys Arg Leu Glu Glu Lys Gln Ser Pro Glu 
                485                 490                 495     


Leu Val Lys Lys His Lys Lys Lys Arg Val Val Pro Lys Lys Pro Pro 
            500                 505                 510         


Pro Ser Pro Gln Pro Thr Glu Glu Asp Pro Glu His Arg Val Arg Val 
        515                 520                 525             


Arg Val Thr Lys Leu Arg Leu Gly Gly Pro Asn Gln Asp Leu Thr Val 
    530                 535                 540                 


Leu Glu Met Lys Arg Glu Asn Pro Gln Leu Lys Gln Ile Glu Gly Leu 
545                 550                 555                 560 


Val Lys Glu Leu Leu Glu Arg Glu Gly Leu Thr Ala Ala Gly Lys Ile 
                565                 570                 575     


Glu Ile Lys Ile Val Arg Pro Trp Ala Glu Gly Thr Glu Glu Gly Ala 
            580                 585                 590         


Arg Trp Leu Thr Asp Glu Asp Thr Arg Asn Leu Lys Glu Ile Phe Phe 
        595                 600                 605             


Asn Ile Leu Val Pro Gly Ala Glu Glu Ala Gln Lys Glu Arg Gln Arg 
    610                 615                 620                 


Gln Lys Glu Leu Glu Ser Asn Tyr Arg Arg Val Trp Gly Ser Pro Gly 
625                 630                 635                 640 


Gly Glu Gly Thr Gly Asp Leu Asp Glu Phe Asp Phe 
                645                 650         


<210>  9836
<211>  612
<212>  PRT
<213>  Homo Sapiens

<400>  9836

Met Ala Ala Glu Thr Leu Leu Ser Ser Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Pro Ala Ser Leu Thr Gly Gly Val Gly Ser Leu Asn 
            20                  25                  30          


Leu Glu Glu Leu Ser Glu Met Arg Tyr Gly Ile Glu Ile Leu Pro Leu 
        35                  40                  45              


Pro Val Met Gly Gly Gln Ser Gln Ser Ser Asp Val Val Ile Val Ser 
    50                  55                  60                  


Ser Lys Tyr Lys Gln Arg Tyr Glu Cys Arg Leu Pro Ala Gly Ala Ile 
65                  70                  75                  80  


His Phe Gln Arg Glu Arg Glu Glu Glu Thr Pro Ala Tyr Gln Gly Pro 
                85                  90                  95      


Gly Ile Pro Glu Leu Leu Ser Pro Met Arg Asp Ala Pro Cys Leu Leu 
            100                 105                 110         


Lys Thr Lys Asp Trp Trp Thr Tyr Glu Phe Cys Tyr Gly Arg His Ile 
        115                 120                 125             


Gln Gln Tyr His Met Glu Asp Ser Glu Ile Lys Gly Glu Val Leu Tyr 
    130                 135                 140                 


Leu Gly Tyr Tyr Gln Ser Ala Phe Asp Trp Asp Asp Glu Thr Ala Lys 
145                 150                 155                 160 


Ala Ser Lys Gln His Arg Leu Lys Arg Tyr His Ser Gln Thr Tyr Gly 
                165                 170                 175     


Asn Gly Ser Lys Cys Asp Leu Asn Gly Arg Pro Arg Glu Ala Glu Val 
            180                 185                 190         


Arg Phe Leu Cys Asp Glu Gly Ala Gly Ile Ser Gly Asp Tyr Ile Asp 
        195                 200                 205             


Arg Val Asp Glu Pro Leu Ser Cys Ser Tyr Val Leu Thr Ile Arg Thr 
    210                 215                 220                 


Pro Arg Leu Cys Pro His Pro Leu Leu Arg Pro Pro Pro Ser Ala Ala 
225                 230                 235                 240 


Pro Gln Ala Ile Leu Cys His Pro Ser Leu Gln Pro Glu Glu Tyr Met 
                245                 250                 255     


Ala Tyr Val Gln Arg Gln Ala Asp Ser Lys Gln Tyr Gly Asp Lys Ile 
            260                 265                 270         


Ile Glu Glu Leu Gln Asp Leu Gly Pro Gln Val Trp Ser Glu Thr Lys 
        275                 280                 285             


Ser Gly Val Ala Pro Gln Lys Met Ala Gly Ala Ser Pro Thr Lys Asp 
    290                 295                 300                 


Asp Ser Lys Asp Ser Asp Phe Trp Lys Met Leu Asn Glu Pro Glu Asp 
305                 310                 315                 320 


Gln Ala Pro Gly Gly Glu Glu Val Pro Ala Glu Glu Gln Asp Pro Ser 
                325                 330                 335     


Pro Glu Ala Ala Asp Ser Ala Ser Gly Ala Pro Asn Asp Phe Gln Asn 
            340                 345                 350         


Asn Val Gln Val Lys Val Ile Arg Ser Pro Ala Asp Leu Ile Arg Phe 
        355                 360                 365             


Ile Glu Glu Leu Lys Gly Gly Thr Lys Lys Gly Lys Pro Asn Ile Gly 
    370                 375                 380                 


Gln Glu Gln Pro Val Asp Asp Ala Ala Glu Val Pro Gln Arg Glu Pro 
385                 390                 395                 400 


Glu Lys Glu Arg Gly Asp Pro Glu Arg Gln Arg Glu Met Glu Glu Glu 
                405                 410                 415     


Glu Asp Glu Asp Glu Asp Glu Asp Glu Asp Glu Asp Glu Arg Gln Leu 
            420                 425                 430         


Leu Gly Glu Phe Glu Lys Glu Leu Glu Gly Ile Leu Leu Pro Ser Asp 
        435                 440                 445             


Arg Asp Arg Leu Arg Ser Glu Val Lys Ala Gly Met Glu Arg Glu Leu 
    450                 455                 460                 


Glu Asn Ile Ile Gln Glu Thr Glu Lys Glu Leu Asp Pro Asp Gly Leu 
465                 470                 475                 480 


Lys Lys Glu Ser Glu Arg Asp Arg Ala Met Leu Ala Leu Thr Ser Thr 
                485                 490                 495     


Leu Asn Lys Leu Ile Lys Arg Leu Glu Glu Lys Gln Ser Pro Glu Leu 
            500                 505                 510         


Val Lys Lys His Lys Lys Lys Arg Val Val Pro Lys Lys Pro Pro Pro 
        515                 520                 525             


Ser Pro Gln Pro Thr Gly Lys Ile Glu Ile Lys Ile Val Arg Pro Trp 
    530                 535                 540                 


Ala Glu Gly Thr Glu Glu Gly Ala Arg Trp Leu Thr Asp Glu Asp Thr 
545                 550                 555                 560 


Arg Asn Leu Lys Glu Ile Phe Phe Asn Ile Leu Val Pro Gly Ala Glu 
                565                 570                 575     


Glu Ala Gln Lys Glu Arg Gln Arg Gln Lys Glu Leu Glu Ser Asn Tyr 
            580                 585                 590         


Arg Arg Val Trp Gly Ser Pro Gly Gly Glu Gly Thr Gly Asp Leu Asp 
        595                 600                 605             


Glu Phe Asp Phe 
    610         


<210>  9837
<211>  580
<212>  PRT
<213>  Homo Sapiens

<400>  9837

Met Ala Ala Glu Thr Leu Leu Ser Ser Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Pro Ala Ser Leu Thr Gly Gly Val Gly Ser Leu Asn 
            20                  25                  30          


Leu Glu Glu Leu Ser Glu Met Arg Tyr Gly Ile Glu Ile Leu Pro Leu 
        35                  40                  45              


Pro Val Met Gly Gly Gln Ser Gln Ser Ser Asp Val Val Ile Val Ser 
    50                  55                  60                  


Ser Lys Tyr Lys Gln Arg Tyr Glu Cys Arg Leu Pro Ala Gly Ala Ile 
65                  70                  75                  80  


His Phe Gln Arg Glu Arg Glu Glu Glu Thr Pro Ala Tyr Gln Gly Pro 
                85                  90                  95      


Gly Ile Pro Glu Leu Leu Ser Pro Met Arg Asp Ala Pro Cys Leu Leu 
            100                 105                 110         


Lys Thr Lys Asp Trp Trp Thr Tyr Glu Phe Cys Tyr Gly Arg His Ile 
        115                 120                 125             


Gln Gln Tyr His Met Glu Asp Ser Glu Ile Lys Gly Glu Val Leu Tyr 
    130                 135                 140                 


Leu Gly Tyr Tyr Gln Ser Ala Phe Asp Trp Asp Asp Glu Thr Ala Lys 
145                 150                 155                 160 


Phe Leu Cys Asp Glu Gly Ala Gly Ile Ser Gly Asp Tyr Ile Asp Arg 
                165                 170                 175     


Val Asp Glu Pro Leu Ser Cys Ser Tyr Val Leu Thr Ile Arg Thr Pro 
            180                 185                 190         


Arg Leu Cys Pro His Pro Leu Leu Arg Pro Pro Pro Ser Ala Ala Pro 
        195                 200                 205             


Gln Ala Ile Leu Cys His Pro Ser Leu Gln Pro Glu Glu Tyr Met Ala 
    210                 215                 220                 


Tyr Val Gln Arg Gln Ala Val Asp Ser Lys Gln Tyr Gly Asp Lys Ile 
225                 230                 235                 240 


Ile Glu Glu Leu Gln Asp Leu Gly Pro Gln Val Trp Ser Glu Thr Lys 
                245                 250                 255     


Ser Gly Val Ala Pro Gln Lys Met Ala Gly Ala Ser Pro Thr Lys Asp 
            260                 265                 270         


Asp Ser Lys Asp Ser Asp Phe Trp Lys Met Leu Asn Glu Pro Glu Asp 
        275                 280                 285             


Gln Ala Pro Gly Gly Glu Glu Val Pro Ala Glu Glu Gln Asp Pro Ser 
    290                 295                 300                 


Pro Glu Ala Ala Asp Ser Ala Ser Gly Ala Pro Asn Asp Phe Gln Asn 
305                 310                 315                 320 


Asn Val Gln Val Lys Val Ile Arg Ser Pro Ala Asp Leu Ile Arg Phe 
                325                 330                 335     


Ile Glu Glu Leu Lys Gly Gly Thr Lys Lys Gly Lys Pro Asn Ile Gly 
            340                 345                 350         


Gln Glu Gln Pro Val Asp Asp Ala Ala Glu Val Pro Gln Arg Glu Pro 
        355                 360                 365             


Glu Lys Glu Arg Gly Asp Pro Glu Arg Gln Arg Glu Met Glu Glu Glu 
    370                 375                 380                 


Glu Asp Glu Asp Glu Asp Glu Asp Glu Asp Glu Asp Glu Arg Gln Leu 
385                 390                 395                 400 


Leu Gly Glu Phe Glu Lys Glu Leu Glu Gly Ile Leu Leu Pro Ser Asp 
                405                 410                 415     


Arg Asp Arg Leu Arg Ser Glu Val Lys Ala Gly Met Glu Arg Glu Leu 
            420                 425                 430         


Glu Asn Ile Ile Gln Glu Thr Glu Lys Glu Leu Asp Pro Asp Gly Leu 
        435                 440                 445             


Lys Lys Glu Ser Glu Arg Asp Arg Ala Met Leu Ala Leu Thr Ser Thr 
    450                 455                 460                 


Leu Asn Lys Leu Ile Lys Arg Leu Glu Glu Lys Gln Ser Pro Glu Leu 
465                 470                 475                 480 


Val Lys Lys His Lys Lys Lys Arg Val Val Pro Lys Lys Pro Pro Pro 
                485                 490                 495     


Ser Pro Gln Pro Thr Gly Lys Ile Glu Ile Lys Ile Val Arg Pro Trp 
            500                 505                 510         


Ala Glu Gly Thr Glu Glu Gly Ala Arg Trp Leu Thr Asp Glu Asp Thr 
        515                 520                 525             


Arg Asn Leu Lys Glu Ile Phe Phe Asn Ile Leu Val Pro Gly Ala Glu 
    530                 535                 540                 


Glu Ala Gln Lys Glu Arg Gln Arg Gln Lys Glu Leu Glu Ser Asn Tyr 
545                 550                 555                 560 


Arg Arg Val Trp Gly Ser Pro Gly Gly Glu Gly Thr Gly Asp Leu Asp 
                565                 570                 575     


Glu Phe Asp Phe 
            580 


<210>  9838
<211>  146
<212>  PRT
<213>  Homo Sapiens

<400>  9838

Met Ala Ala Glu Thr Leu Leu Ser Ser Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Pro Ala Ser Leu Thr Gly Gly Val Gly Ser Leu Asn 
            20                  25                  30          


Leu Glu Glu Leu Ser Glu Met Arg Tyr Gly Ile Glu Ile Leu Pro Leu 
        35                  40                  45              


Pro Val Met Gly Gly Gln Ser Gln Ser Ser Asp Val Val Ile Val Ser 
    50                  55                  60                  


Ser Lys Tyr Lys Gln Arg Tyr Glu Cys Arg Leu Pro Ala Gly Ala Ile 
65                  70                  75                  80  


His Phe Gln Arg Glu Arg Glu Glu Glu Thr Pro Ala Tyr Gln Gly Pro 
                85                  90                  95      


Gly Ile Pro Glu Leu Leu Ser Pro Met Arg Asp Ala Pro Cys Leu Leu 
            100                 105                 110         


Lys Thr Lys Asp Trp Trp Thr Tyr Glu Phe Cys Tyr Gly Arg His Ile 
        115                 120                 125             


Gln Gln Tyr His Met Glu Asp Ser Glu Ile Lys Gly Leu Gln Ala Ala 
    130                 135                 140                 


Ser Ser 
145     


<210>  9839
<211>  186
<212>  PRT
<213>  Homo Sapiens

<400>  9839

Met Ala Ala Glu Thr Leu Leu Ser Ser Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Pro Ala Ser Leu Thr Gly Gly Val Gly Ser Leu Asn 
            20                  25                  30          


Leu Glu Glu Leu Ser Glu Met Arg Tyr Gly Ile Glu Ile Leu Pro Leu 
        35                  40                  45              


Pro Val Met Gly Gly Gln Ser Gln Ser Ser Asp Val Val Ile Val Ser 
    50                  55                  60                  


Ser Lys Tyr Lys Gln Arg Tyr Glu Cys Arg Leu Pro Ala Gly Ala Ile 
65                  70                  75                  80  


His Phe Gln Arg Glu Arg Glu Glu Glu Thr Pro Ala Tyr Gln Gly Pro 
                85                  90                  95      


Gly Ile Pro Glu Leu Leu Ser Pro Met Arg Asp Ala Pro Cys Leu Leu 
            100                 105                 110         


Lys Thr Lys Asp Trp Trp Thr Tyr Glu Phe Cys Tyr Gly Arg His Ile 
        115                 120                 125             


Gln Gln Tyr His Met Glu Gly Ile Leu Leu Pro Ser Asp Arg Asp Arg 
    130                 135                 140                 


Leu Arg Ser Glu Val Lys Ala Gly Met Glu Arg Glu Leu Glu Asn Ile 
145                 150                 155                 160 


Ile Gln Glu Thr Glu Lys Glu Leu Asp Pro Asp Gly Leu Lys Lys Glu 
                165                 170                 175     


Ser Glu Arg Asp Arg Ala Met Leu Ala Leu 
            180                 185     


<210>  9840
<211>  162
<212>  PRT
<213>  Homo Sapiens

<400>  9840

Met Ala Ala Glu Thr Leu Leu Ser Ser Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Pro Ala Ser Leu Thr Gly Gly Val Gly Ser Leu Asn 
            20                  25                  30          


Leu Glu Glu Leu Ser Glu Met Arg Tyr Gly Ile Glu Ile Leu Pro Leu 
        35                  40                  45              


Pro Val Met Gly Gly Gln Ser Gln Ser Ser Asp Val Val Ile Val Ser 
    50                  55                  60                  


Ser Lys Tyr Lys Gln Arg Tyr Glu Cys Arg Leu Pro Ala Gly Ala Ile 
65                  70                  75                  80  


His Phe Gln Arg Glu Arg Glu Glu Glu Thr Pro Ala Tyr Gln Gly Pro 
                85                  90                  95      


Gly Ile Pro Glu Leu Leu Ser Pro Met Arg Asp Ala Pro Cys Leu Leu 
            100                 105                 110         


Lys Thr Tyr Gly Asn Gly Ser Lys Cys Asp Leu Asn Gly Arg Pro Arg 
        115                 120                 125             


Glu Ala Glu Val Arg Phe Leu Cys Asp Glu Gly Ala Gly Ile Ser Gly 
    130                 135                 140                 


Asp Tyr Ile Asp Arg Val Asp Glu Pro Leu Ser Cys Ser Tyr Val Leu 
145                 150                 155                 160 


Thr Ile 
        


<210>  9841
<211>  538
<212>  PRT
<213>  Homo Sapiens

<400>  9841

Met Ala Ala Glu Thr Leu Leu Ser Ser Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Pro Ala Ser Leu Thr Gly Gly Val Gly Ser Leu Asn 
            20                  25                  30          


Leu Glu Glu Leu Ser Glu Met Arg Tyr Gly Ile Glu Ile Leu Pro Leu 
        35                  40                  45              


Pro Val Met Gly Gly Gln Thr Lys Asp Trp Trp Thr Tyr Glu Phe Cys 
    50                  55                  60                  


Tyr Gly Arg His Ile Gln Gln Tyr His Met Glu Asp Ser Glu Ile Lys 
65                  70                  75                  80  


Gly Glu Val Leu Tyr Leu Gly Tyr Tyr Gln Ser Ala Phe Asp Trp Asp 
                85                  90                  95      


Asp Glu Thr Ala Lys Ala Ser Lys Gln His Arg Leu Lys Arg Tyr His 
            100                 105                 110         


Ser Gln Thr Tyr Gly Asn Gly Ser Lys Cys Asp Leu Asn Gly Arg Pro 
        115                 120                 125             


Arg Glu Ala Glu Val Arg Phe Leu Cys Asp Glu Gly Ala Gly Ile Ser 
    130                 135                 140                 


Gly Asp Tyr Ile Asp Arg Val Asp Glu Pro Leu Ser Cys Ser Tyr Val 
145                 150                 155                 160 


Leu Thr Ile Arg Thr Pro Arg Leu Cys Pro His Pro Leu Leu Arg Pro 
                165                 170                 175     


Pro Pro Ser Ala Ala Pro Gln Ala Ile Leu Cys His Pro Ser Leu Gln 
            180                 185                 190         


Pro Glu Glu Tyr Met Ala Tyr Val Gln Arg Gln Ala Asp Ser Lys Gln 
        195                 200                 205             


Tyr Gly Asp Lys Ile Ile Glu Glu Leu Gln Asp Leu Gly Pro Gln Val 
    210                 215                 220                 


Trp Ser Glu Thr Lys Ser Gly Val Ala Pro Gln Lys Met Ala Gly Ala 
225                 230                 235                 240 


Ser Pro Thr Lys Asp Asp Ser Lys Asp Ser Asp Phe Trp Lys Met Leu 
                245                 250                 255     


Asn Glu Pro Glu Asp Gln Ala Pro Gly Gly Glu Glu Val Pro Ala Glu 
            260                 265                 270         


Glu Gln Asp Pro Ser Pro Glu Ala Ala Asp Ser Ala Ser Gly Ala Pro 
        275                 280                 285             


Asn Asp Phe Gln Asn Asn Val Gln Val Lys Val Ile Arg Ser Pro Ala 
    290                 295                 300                 


Asp Leu Ile Arg Phe Ile Glu Glu Leu Lys Gly Gly Thr Lys Lys Gly 
305                 310                 315                 320 


Lys Pro Asn Ile Gly Gln Glu Gln Pro Val Asp Asp Ala Ala Glu Val 
                325                 330                 335     


Pro Gln Arg Glu Pro Glu Lys Glu Arg Gly Asp Pro Glu Arg Gln Arg 
            340                 345                 350         


Glu Met Glu Glu Glu Glu Asp Glu Asp Glu Asp Glu Asp Glu Asp Glu 
        355                 360                 365             


Asp Glu Arg Gln Leu Leu Gly Glu Phe Glu Lys Glu Leu Glu Gly Ile 
    370                 375                 380                 


Leu Leu Pro Ser Asp Arg Asp Arg Leu Arg Ser Glu Thr Glu Lys Glu 
385                 390                 395                 400 


Leu Asp Pro Asp Gly Leu Lys Lys Glu Ser Glu Arg Asp Arg Ala Met 
                405                 410                 415     


Leu Ala Leu Thr Ser Thr Leu Asn Lys Leu Ile Lys Arg Leu Glu Glu 
            420                 425                 430         


Lys Gln Ser Pro Glu Leu Val Lys Lys His Lys Lys Lys Arg Val Val 
        435                 440                 445             


Pro Lys Lys Pro Pro Pro Ser Pro Gln Pro Thr Gly Lys Ile Glu Ile 
    450                 455                 460                 


Lys Ile Val Arg Pro Trp Ala Glu Gly Thr Glu Glu Gly Ala Arg Trp 
465                 470                 475                 480 


Leu Thr Asp Glu Asp Thr Arg Asn Leu Lys Glu Ile Phe Phe Asn Ile 
                485                 490                 495     


Leu Val Pro Gly Ala Glu Glu Ala Gln Lys Glu Arg Gln Arg Gln Lys 
            500                 505                 510         


Glu Leu Glu Ser Asn Tyr Arg Arg Val Trp Gly Ser Pro Gly Gly Glu 
        515                 520                 525             


Gly Thr Gly Asp Leu Asp Glu Phe Asp Phe 
    530                 535             


<210>  9842
<211>  252
<212>  PRT
<213>  Homo Sapiens

<400>  9842

Met Ala Leu Val Leu Ile Leu Gln Leu Leu Thr Leu Phe Pro Pro Ala 
1               5                   10                  15      


Ser Tyr His Pro Lys Pro Trp Leu Gly Ala Gln Pro Ala Thr Val Val 
            20                  25                  30          


Thr Pro Gly Val Asn Val Thr Leu Arg Cys Arg Ala Pro Gln Pro Ala 
        35                  40                  45              


Trp Arg Phe Gly Leu Phe Lys Pro Gly Glu Ile Ala Pro Leu Leu Phe 
    50                  55                  60                  


Arg Asp Val Ser Ser Glu Leu Ala Glu Phe Phe Leu Glu Glu Val Thr 
65                  70                  75                  80  


Pro Ala Gln Gly Gly Ser Tyr Arg Cys Cys Tyr Arg Arg Pro Asp Trp 
                85                  90                  95      


Gly Pro Gly Val Trp Ser Gln Pro Ser Asp Val Leu Glu Leu Leu Val 
            100                 105                 110         


Thr Glu Glu Leu Pro Arg Pro Ser Leu Val Ala Leu Pro Gly Pro Val 
        115                 120                 125             


Val Gly Pro Gly Ala Asn Val Ser Leu Arg Cys Ala Gly Arg Leu Arg 
    130                 135                 140                 


Asn Met Ser Phe Val Leu Tyr Arg Glu Gly Val Ala Ala Pro Leu Gln 
145                 150                 155                 160 


Tyr Arg His Ser Ala Gln Pro Trp Ala Asp Phe Thr Leu Leu Gly Ala 
                165                 170                 175     


Arg Ala Pro Gly Thr Tyr Ser Cys Tyr Tyr His Thr Pro Ser Ala Pro 
            180                 185                 190         


Tyr Val Leu Ser Gln Arg Ser Glu Val Leu Val Ile Ser Trp Glu Asp 
        195                 200                 205             


Ser Gly Ser Ser Asp Tyr Thr Arg Gly Asn Leu Val Arg Leu Gly Leu 
    210                 215                 220                 


Ala Gly Leu Val Leu Ile Ser Leu Gly Ala Leu Val Thr Phe Asp Trp 
225                 230                 235                 240 


Arg Ser Gln Asn Arg Ala Pro Ala Gly Ile Arg Pro 
                245                 250         


<210>  9843
<211>  271
<212>  PRT
<213>  Homo Sapiens

<400>  9843

Met Ala Leu Val Leu Ile Leu Gln Leu Leu Thr Leu Phe Pro Pro Ala 
1               5                   10                  15      


Ser Tyr His Pro Lys Pro Trp Leu Gly Ala Gln Pro Ala Thr Val Val 
            20                  25                  30          


Thr Pro Gly Val Asn Val Thr Leu Arg Cys Arg Ala Pro Gln Pro Ala 
        35                  40                  45              


Trp Arg Phe Gly Leu Phe Lys Pro Gly Glu Ile Ala Pro Leu Leu Phe 
    50                  55                  60                  


Arg Asp Val Ser Ser Glu Leu Ala Glu Phe Phe Leu Glu Glu Val Thr 
65                  70                  75                  80  


Pro Ala Gln Gly Gly Ser Tyr Arg Cys Cys Tyr Arg Arg Pro Asp Trp 
                85                  90                  95      


Gly Pro Gly Val Trp Ser Gln Pro Ser Asp Val Leu Glu Leu Leu Val 
            100                 105                 110         


Thr Glu Glu Leu Pro Arg Pro Ser Leu Val Ala Leu Pro Gly Pro Val 
        115                 120                 125             


Val Gly Pro Gly Ala Asn Val Ser Leu Arg Cys Ala Gly Arg Leu Arg 
    130                 135                 140                 


Asn Met Ser Phe Val Leu Tyr Arg Glu Gly Val Ala Ala Pro Leu Gln 
145                 150                 155                 160 


Tyr Arg His Ser Ala Gln Pro Trp Ala Asp Phe Thr Leu Leu Gly Ala 
                165                 170                 175     


Arg Ala Pro Gly Thr Tyr Ser Cys Tyr Tyr His Thr Pro Ser Ala Pro 
            180                 185                 190         


Tyr Val Leu Ser Gln Arg Ser Glu Val Leu Val Ile Ser Trp Glu Gly 
        195                 200                 205             


Glu Gly Pro Glu Ala Arg Pro Ala Ser Ser Ala Pro Gly Met Gln Ala 
    210                 215                 220                 


Pro Gly Pro Pro Pro Ser Asp Pro Gly Ala Gln Ala Pro Ser Leu Ser 
225                 230                 235                 240 


Ser Phe Arg Pro Arg Gly Leu Val Leu Gln Pro Leu Leu Pro Gln Thr 
                245                 250                 255     


Gln Asp Ser Trp Asp Pro Ala Pro Pro Pro Ser Asp Pro Gly Val 
            260                 265                 270     


<210>  9844
<211>  271
<212>  PRT
<213>  Homo Sapiens

<400>  9844

Met Ala Leu Val Leu Ile Leu Gln Leu Leu Thr Leu Phe Pro Pro Ala 
1               5                   10                  15      


Ser Tyr His Pro Lys Pro Trp Leu Gly Ala Gln Pro Ala Thr Val Val 
            20                  25                  30          


Thr Pro Gly Val Asn Val Thr Leu Arg Cys Arg Ala Pro Gln Pro Ala 
        35                  40                  45              


Trp Arg Phe Gly Leu Phe Lys Pro Gly Glu Ile Ala Pro Leu Leu Phe 
    50                  55                  60                  


Arg Asp Val Ser Ser Glu Leu Ala Glu Phe Phe Leu Glu Glu Val Thr 
65                  70                  75                  80  


Pro Ala Gln Gly Gly Ser Tyr Arg Cys Cys Tyr Arg Arg Pro Asp Trp 
                85                  90                  95      


Gly Pro Gly Val Trp Ser Gln Pro Ser Asp Val Leu Glu Leu Leu Val 
            100                 105                 110         


Thr Glu Glu Leu Pro Arg Pro Ser Leu Val Ala Leu Pro Gly Pro Val 
        115                 120                 125             


Val Gly Pro Gly Ala Asn Val Ser Leu Arg Cys Ala Gly Arg Leu Arg 
    130                 135                 140                 


Asn Met Ser Phe Val Leu Tyr Arg Glu Gly Val Ala Ala Pro Leu Gln 
145                 150                 155                 160 


Tyr Arg His Ser Ala Gln Pro Trp Ala Asp Phe Thr Leu Leu Gly Ala 
                165                 170                 175     


Arg Ala Pro Gly Thr Tyr Ser Cys Tyr Tyr His Thr Pro Ser Ala Pro 
            180                 185                 190         


Tyr Val Leu Ser Gln Arg Ser Glu Val Leu Val Ile Ser Trp Glu Gly 
        195                 200                 205             


Glu Gly Pro Glu Ala Arg Pro Ala Ser Ser Ala Pro Gly Met Gln Ala 
    210                 215                 220                 


Pro Gly Pro Pro Pro Ser Asp Pro Gly Ala Gln Ala Pro Ser Leu Ser 
225                 230                 235                 240 


Ser Phe Arg Pro Arg Gly Leu Val Leu Gln Pro Leu Leu Pro Gln Thr 
                245                 250                 255     


Gln Asp Ser Trp Asp Pro Ala Pro Pro Pro Ser Asp Pro Gly Val 
            260                 265                 270     


<210>  9845
<211>  268
<212>  PRT
<213>  Homo Sapiens

<400>  9845

Met Ala Leu Val Leu Ile Leu Gln Leu Leu Thr Leu Trp Pro Leu Cys 
1               5                   10                  15      


His Thr Asp Ile Thr Pro Ser Ala Ala Pro Phe Ile Val Pro Pro Ala 
            20                  25                  30          


Ser Tyr His Pro Lys Pro Trp Leu Gly Ala Gln Pro Ala Thr Val Val 
        35                  40                  45              


Thr Pro Gly Val Asn Val Thr Leu Arg Cys Arg Ala Pro Gln Pro Ala 
    50                  55                  60                  


Trp Arg Phe Gly Leu Phe Lys Pro Gly Glu Ile Ala Pro Leu Leu Phe 
65                  70                  75                  80  


Arg Asp Val Ser Ser Glu Leu Ala Glu Phe Phe Leu Glu Glu Val Thr 
                85                  90                  95      


Pro Ala Gln Gly Gly Ser Tyr Arg Cys Cys Tyr Arg Arg Pro Asp Trp 
            100                 105                 110         


Gly Pro Gly Val Trp Ser Gln Pro Ser Asp Val Leu Glu Leu Leu Val 
        115                 120                 125             


Thr Glu Glu Leu Pro Arg Pro Ser Leu Val Ala Leu Pro Gly Pro Val 
    130                 135                 140                 


Val Gly Pro Gly Ala Asn Val Ser Leu Arg Cys Ala Gly Arg Leu Arg 
145                 150                 155                 160 


Asn Met Ser Phe Val Leu Tyr Arg Glu Gly Val Ala Ala Pro Leu Gln 
                165                 170                 175     


Tyr Arg His Ser Ala Gln Pro Trp Ala Asp Phe Thr Leu Leu Gly Ala 
            180                 185                 190         


Arg Ala Pro Gly Thr Tyr Ser Cys Tyr Tyr His Thr Pro Ser Ala Pro 
        195                 200                 205             


Tyr Val Leu Ser Gln Arg Ser Glu Val Leu Val Ile Ser Trp Glu Asp 
    210                 215                 220                 


Ser Gly Ser Ser Asp Tyr Thr Arg Gly Asn Leu Val Arg Leu Gly Leu 
225                 230                 235                 240 


Ala Gly Leu Val Leu Ile Ser Leu Gly Ala Leu Val Thr Phe Asp Trp 
                245                 250                 255     


Arg Ser Gln Asn Arg Ala Pro Ala Gly Ile Arg Pro 
            260                 265             


<210>  9846
<211>  161
<212>  PRT
<213>  Homo Sapiens

<400>  9846

Met Ala Leu Val Leu Ile Leu Gln Leu Leu Thr Leu Trp Pro Leu Cys 
1               5                   10                  15      


His Thr Asp Ile Thr Pro Ser Ala Gly Arg Ile Leu Ser Gly Gly Gly 
            20                  25                  30          


Asp Ser Ser Pro Arg Gly Lys Leu Pro Leu Leu Leu Pro Lys Ala Arg 
        35                  40                  45              


Leu Gly Ala Gly Cys Leu Val Pro Ala Gln Arg Cys Pro Gly Ala Ala 
    50                  55                  60                  


Gly Asp Arg Gly Ala Ala Ala Ala Val Ala Gly Gly Ala Ala Arg Ala 
65                  70                  75                  80  


Gly Gly Gly Ser Trp Arg Gln Arg Glu Pro Ala Leu Arg Gly Pro Pro 
                85                  90                  95      


Ala Glu His Glu Leu Arg Ala Val Pro Arg Gly Arg Gly Gly Pro Ala 
            100                 105                 110         


Ala Val Pro Pro Leu Arg Ala Ala Leu Gly Arg Leu His Ala Ala Gly 
        115                 120                 125             


Arg Pro Arg Pro Arg His Leu Gln Leu Leu Leu Ser His Ala Leu Arg 
    130                 135                 140                 


Ala Leu Arg Ala Val Ala Ala Gln Arg Gly Ala Gly His Gln Leu Gly 
145                 150                 155                 160 


Arg 
    


<210>  9847
<211>  267
<212>  PRT
<213>  Homo Sapiens

<400>  9847

Met Ala Leu Val Leu Ile Leu Gln Leu Leu Thr Leu Trp Pro Leu Cys 
1               5                   10                  15      


His Thr Asp Ile Thr Pro Ser Val Ala Ile Ile Val Pro Pro Ala Ser 
            20                  25                  30          


Tyr His Pro Lys Pro Trp Leu Gly Ala Gln Pro Ala Thr Val Val Thr 
        35                  40                  45              


Pro Gly Val Asn Val Thr Leu Arg Cys Arg Ala Pro Gln Pro Ala Trp 
    50                  55                  60                  


Arg Phe Gly Leu Phe Lys Pro Gly Glu Ile Ala Pro Leu Leu Phe Arg 
65                  70                  75                  80  


Asp Val Ser Ser Glu Leu Ala Glu Phe Phe Leu Glu Glu Val Thr Pro 
                85                  90                  95      


Ala Gln Gly Gly Ser Tyr Arg Cys Cys Tyr Arg Arg Pro Asp Trp Gly 
            100                 105                 110         


Pro Gly Val Trp Ser Gln Pro Ser Asp Val Leu Glu Leu Leu Val Thr 
        115                 120                 125             


Glu Glu Leu Pro Arg Pro Ser Leu Val Ala Leu Pro Gly Pro Val Val 
    130                 135                 140                 


Gly Pro Gly Ala Asn Val Ser Leu Arg Cys Ala Gly Arg Leu Arg Asn 
145                 150                 155                 160 


Met Ser Phe Val Leu Tyr Arg Glu Gly Val Ala Ala Pro Leu Gln Tyr 
                165                 170                 175     


Arg His Ser Ala Gln Pro Trp Ala Asp Phe Thr Leu Leu Gly Ala Arg 
            180                 185                 190         


Ala Pro Gly Thr Tyr Ser Cys Tyr Tyr His Thr Pro Ser Ala Pro Tyr 
        195                 200                 205             


Val Leu Ser Gln Arg Ser Glu Val Leu Val Ile Ser Trp Glu Asp Ser 
    210                 215                 220                 


Gly Ser Ser Asp Tyr Thr Arg Gly Asn Leu Val Arg Leu Gly Leu Ala 
225                 230                 235                 240 


Gly Leu Val Leu Ile Ser Leu Gly Ala Leu Val Thr Phe Asp Trp Arg 
                245                 250                 255     


Ser Gln Asn Arg Ala Pro Ala Gly Ile Arg Pro 
            260                 265         


<210>  9848
<211>  267
<212>  PRT
<213>  Homo Sapiens

<400>  9848

Met Ala Leu Val Leu Ile Leu Gln Leu Leu Thr Leu Trp Pro Leu Cys 
1               5                   10                  15      


His Thr Asp Ile Thr Pro Ser Val Ala Ile Ile Val Pro Pro Ala Ser 
            20                  25                  30          


Tyr His Pro Lys Pro Trp Leu Gly Ala Gln Pro Ala Thr Val Val Thr 
        35                  40                  45              


Pro Gly Val Asn Val Thr Leu Arg Cys Arg Ala Pro Gln Pro Ala Trp 
    50                  55                  60                  


Arg Phe Gly Leu Phe Lys Pro Gly Glu Ile Ala Pro Leu Leu Phe Arg 
65                  70                  75                  80  


Asp Val Ser Ser Glu Leu Ala Glu Phe Phe Leu Glu Glu Val Thr Pro 
                85                  90                  95      


Ala Gln Gly Gly Ser Tyr Arg Cys Cys Tyr Arg Arg Pro Asp Trp Gly 
            100                 105                 110         


Pro Gly Val Trp Ser Gln Pro Ser Asp Val Leu Glu Leu Leu Val Thr 
        115                 120                 125             


Glu Glu Leu Pro Arg Pro Ser Leu Val Ala Leu Pro Gly Pro Val Val 
    130                 135                 140                 


Gly Pro Gly Ala Asn Val Ser Leu Arg Cys Ala Gly Arg Leu Arg Asn 
145                 150                 155                 160 


Met Ser Phe Val Leu Tyr Arg Glu Gly Val Ala Ala Pro Leu Gln Tyr 
                165                 170                 175     


Arg His Ser Ala Gln Pro Trp Ala Asp Phe Thr Leu Leu Gly Ala Arg 
            180                 185                 190         


Ala Pro Gly Thr Tyr Ser Cys Tyr Tyr His Thr Pro Ser Ala Pro Tyr 
        195                 200                 205             


Val Leu Ser Gln Arg Ser Glu Val Leu Val Ile Ser Trp Glu Asp Ser 
    210                 215                 220                 


Gly Ser Ser Asp Tyr Thr Arg Gly Asn Leu Val Arg Leu Gly Leu Ala 
225                 230                 235                 240 


Gly Leu Val Leu Ile Ser Leu Gly Ala Leu Val Thr Phe Asp Trp Arg 
                245                 250                 255     


Ser Gln Asn Arg Ala Pro Ala Gly Ile Arg Pro 
            260                 265         


<210>  9849
<211>  286
<212>  PRT
<213>  Homo Sapiens

<400>  9849

Met Ala Leu Val Leu Ile Leu Gln Leu Leu Thr Leu Trp Pro Leu Cys 
1               5                   10                  15      


His Thr Asp Ile Thr Pro Ser Val Ala Ile Ile Val Pro Pro Ala Ser 
            20                  25                  30          


Tyr His Pro Lys Pro Trp Leu Gly Ala Gln Pro Ala Thr Val Val Thr 
        35                  40                  45              


Pro Gly Val Asn Val Thr Leu Arg Cys Arg Ala Pro Gln Pro Ala Trp 
    50                  55                  60                  


Arg Phe Gly Leu Phe Lys Pro Gly Glu Ile Ala Pro Leu Leu Phe Arg 
65                  70                  75                  80  


Asp Val Ser Ser Glu Leu Ala Glu Phe Phe Leu Glu Glu Val Thr Pro 
                85                  90                  95      


Ala Gln Gly Gly Ser Tyr Arg Cys Cys Tyr Arg Arg Pro Asp Trp Gly 
            100                 105                 110         


Pro Gly Val Trp Ser Gln Pro Ser Asp Val Leu Glu Leu Leu Val Thr 
        115                 120                 125             


Glu Glu Leu Pro Arg Pro Ser Leu Val Ala Leu Pro Gly Pro Val Val 
    130                 135                 140                 


Gly Pro Gly Ala Asn Val Ser Leu Arg Cys Ala Gly Arg Leu Arg Asn 
145                 150                 155                 160 


Met Ser Phe Val Leu Tyr Arg Glu Gly Val Ala Ala Pro Leu Gln Tyr 
                165                 170                 175     


Arg His Ser Ala Gln Pro Trp Ala Asp Phe Thr Leu Leu Gly Ala Arg 
            180                 185                 190         


Ala Pro Gly Thr Tyr Ser Cys Tyr Tyr His Thr Pro Ser Ala Pro Tyr 
        195                 200                 205             


Val Leu Ser Gln Arg Ser Glu Val Leu Val Ile Ser Trp Glu Gly Glu 
    210                 215                 220                 


Gly Pro Glu Ala Arg Pro Ala Ser Ser Ala Pro Gly Met Gln Ala Pro 
225                 230                 235                 240 


Gly Pro Pro Pro Ser Asp Pro Gly Ala Gln Ala Pro Ser Leu Ser Ser 
                245                 250                 255     


Phe Arg Pro Arg Gly Leu Val Leu Gln Pro Leu Leu Pro Gln Thr Gln 
            260                 265                 270         


Asp Ser Trp Asp Pro Ala Pro Pro Pro Ser Asp Pro Gly Val 
        275                 280                 285     


<210>  9850
<211>  286
<212>  PRT
<213>  Homo Sapiens

<400>  9850

Met Ala Leu Val Leu Ile Leu Gln Leu Leu Thr Leu Trp Pro Leu Cys 
1               5                   10                  15      


His Thr Asp Ile Thr Pro Ser Val Ala Ile Ile Val Pro Pro Ala Ser 
            20                  25                  30          


Tyr His Pro Lys Pro Trp Leu Gly Ala Gln Pro Ala Thr Val Val Thr 
        35                  40                  45              


Pro Gly Val Asn Val Thr Leu Arg Cys Arg Ala Pro Gln Pro Ala Trp 
    50                  55                  60                  


Arg Phe Gly Leu Phe Lys Pro Gly Glu Ile Ala Pro Leu Leu Phe Arg 
65                  70                  75                  80  


Asp Val Ser Ser Glu Leu Ala Glu Phe Phe Leu Glu Glu Val Thr Pro 
                85                  90                  95      


Ala Gln Gly Gly Ser Tyr Arg Cys Cys Tyr Arg Arg Pro Asp Trp Gly 
            100                 105                 110         


Pro Gly Val Trp Ser Gln Pro Ser Asp Val Leu Glu Leu Leu Val Thr 
        115                 120                 125             


Glu Glu Leu Pro Arg Pro Ser Leu Val Ala Leu Pro Gly Pro Val Val 
    130                 135                 140                 


Gly Pro Gly Ala Asn Val Ser Leu Arg Cys Ala Gly Arg Leu Arg Asn 
145                 150                 155                 160 


Met Ser Phe Val Leu Tyr Arg Glu Gly Val Ala Ala Pro Leu Gln Tyr 
                165                 170                 175     


Arg His Ser Ala Gln Pro Trp Ala Asp Phe Thr Leu Leu Gly Ala Arg 
            180                 185                 190         


Ala Pro Gly Thr Tyr Ser Cys Tyr Tyr His Thr Pro Ser Ala Pro Tyr 
        195                 200                 205             


Val Leu Ser Gln Arg Ser Glu Val Leu Val Ile Ser Trp Glu Gly Glu 
    210                 215                 220                 


Gly Pro Glu Ala Arg Pro Ala Ser Ser Ala Pro Gly Met Gln Ala Pro 
225                 230                 235                 240 


Gly Pro Pro Pro Ser Asp Pro Gly Ala Gln Ala Pro Ser Leu Ser Ser 
                245                 250                 255     


Phe Arg Pro Arg Gly Leu Val Leu Gln Pro Leu Leu Pro Gln Thr Gln 
            260                 265                 270         


Asp Ser Trp Asp Pro Ala Pro Pro Pro Ser Asp Pro Gly Val 
        275                 280                 285     


<210>  9851
<211>  263
<212>  PRT
<213>  Homo Sapiens

<400>  9851

Met Ala Leu Val Leu Ile Leu Gln Leu Leu Thr Leu Trp Pro Leu Cys 
1               5                   10                  15      


His Thr Asp Ile Thr Pro Ser Val Pro Pro Ala Ser Tyr His Pro Lys 
            20                  25                  30          


Pro Trp Leu Gly Ala Gln Pro Ala Thr Val Val Thr Pro Gly Val Asn 
        35                  40                  45              


Val Thr Leu Arg Cys Arg Ala Pro Gln Pro Ala Trp Arg Phe Gly Leu 
    50                  55                  60                  


Phe Lys Pro Gly Glu Ile Ala Pro Leu Leu Phe Arg Asp Val Ser Ser 
65                  70                  75                  80  


Glu Leu Ala Glu Phe Phe Leu Glu Glu Val Thr Pro Ala Gln Gly Gly 
                85                  90                  95      


Ser Tyr Arg Cys Cys Tyr Arg Arg Pro Asp Trp Gly Pro Gly Val Trp 
            100                 105                 110         


Ser Gln Pro Ser Asp Val Leu Glu Leu Leu Val Thr Glu Glu Leu Pro 
        115                 120                 125             


Arg Pro Ser Leu Val Ala Leu Pro Gly Pro Val Val Gly Pro Gly Ala 
    130                 135                 140                 


Asn Val Ser Leu Arg Cys Ala Gly Arg Leu Arg Asn Met Ser Phe Val 
145                 150                 155                 160 


Leu Tyr Arg Glu Gly Val Ala Ala Pro Leu Gln Tyr Arg His Ser Ala 
                165                 170                 175     


Gln Pro Trp Ala Asp Phe Thr Leu Leu Gly Ala Arg Ala Pro Gly Thr 
            180                 185                 190         


Tyr Ser Cys Tyr Tyr His Thr Pro Ser Ala Pro Tyr Val Leu Ser Gln 
        195                 200                 205             


Arg Ser Glu Val Leu Val Ile Ser Trp Glu Asp Ser Gly Ser Ser Asp 
    210                 215                 220                 


Tyr Thr Arg Gly Asn Leu Val Arg Leu Gly Leu Ala Gly Leu Val Leu 
225                 230                 235                 240 


Ile Ser Leu Gly Ala Leu Val Thr Phe Asp Trp Arg Ser Gln Asn Arg 
                245                 250                 255     


Ala Pro Ala Gly Ile Arg Pro 
            260             


<210>  9852
<211>  282
<212>  PRT
<213>  Homo Sapiens

<400>  9852

Met Ala Leu Val Leu Ile Leu Gln Leu Leu Thr Leu Trp Pro Leu Cys 
1               5                   10                  15      


His Thr Asp Ile Thr Pro Ser Val Pro Pro Ala Ser Tyr His Pro Lys 
            20                  25                  30          


Pro Trp Leu Gly Ala Gln Pro Ala Thr Val Val Thr Pro Gly Val Asn 
        35                  40                  45              


Val Thr Leu Arg Cys Arg Ala Pro Gln Pro Ala Trp Arg Phe Gly Leu 
    50                  55                  60                  


Phe Lys Pro Gly Glu Ile Ala Pro Leu Leu Phe Arg Asp Val Ser Ser 
65                  70                  75                  80  


Glu Leu Ala Glu Phe Phe Leu Glu Glu Val Thr Pro Ala Gln Gly Gly 
                85                  90                  95      


Ser Tyr Arg Cys Cys Tyr Arg Arg Pro Asp Trp Gly Pro Gly Val Trp 
            100                 105                 110         


Ser Gln Pro Ser Asp Val Leu Glu Leu Leu Val Thr Glu Glu Leu Pro 
        115                 120                 125             


Arg Pro Ser Leu Val Ala Leu Pro Gly Pro Val Val Gly Pro Gly Ala 
    130                 135                 140                 


Asn Val Ser Leu Arg Cys Ala Gly Arg Leu Arg Asn Met Ser Phe Val 
145                 150                 155                 160 


Leu Tyr Arg Glu Gly Val Ala Ala Pro Leu Gln Tyr Arg His Ser Ala 
                165                 170                 175     


Gln Pro Trp Ala Asp Phe Thr Leu Leu Gly Ala Arg Ala Pro Gly Thr 
            180                 185                 190         


Tyr Ser Cys Tyr Tyr His Thr Pro Ser Ala Pro Tyr Val Leu Ser Gln 
        195                 200                 205             


Arg Ser Glu Val Leu Val Ile Ser Trp Glu Gly Glu Gly Pro Glu Ala 
    210                 215                 220                 


Arg Pro Ala Ser Ser Ala Pro Gly Met Gln Ala Pro Gly Pro Pro Pro 
225                 230                 235                 240 


Ser Asp Pro Gly Ala Gln Ala Pro Ser Leu Ser Ser Phe Arg Pro Arg 
                245                 250                 255     


Gly Leu Val Leu Gln Pro Leu Leu Pro Gln Thr Gln Asp Ser Trp Asp 
            260                 265                 270         


Pro Ala Pro Pro Pro Ser Asp Pro Gly Val 
        275                 280         


<210>  9853
<211>  231
<212>  PRT
<213>  Homo Sapiens

<400>  9853

Met Ala Ser Met Ala Ala Ile Gly Ser Cys Ser Lys Glu Tyr Arg Val 
1               5                   10                  15      


Leu Leu Gly Gln Leu Gln Lys Gln Thr Asp Leu Met Gln Asp Thr Ser 
            20                  25                  30          


Arg Leu Leu Asp Pro Tyr Ile Arg Ile Gln Gly Leu Asp Val Pro Lys 
        35                  40                  45              


Leu Arg Glu His Cys Arg Glu Arg Pro Gly Ala Phe Pro Ser Glu Glu 
    50                  55                  60                  


Thr Leu Arg Gly Leu Gly Arg Arg Gly Phe Leu Gln Thr Leu Asn Ala 
65                  70                  75                  80  


Thr Leu Gly Cys Val Leu His Arg Leu Ala Asp Leu Glu Gln Arg Leu 
                85                  90                  95      


Pro Lys Ala Gln Asp Leu Glu Arg Ser Gly Leu Asn Ile Glu Asp Leu 
            100                 105                 110         


Glu Lys Leu Gln Met Ala Arg Pro Asn Ile Leu Gly Leu Arg Asn Asn 
        115                 120                 125             


Ile Tyr Cys Met Ala Gln Leu Leu Asp Asn Ser Asp Thr Ala Glu Pro 
    130                 135                 140                 


Thr Lys Ala Gly Arg Gly Ala Ser Gln Pro Pro Thr Pro Thr Pro Ala 
145                 150                 155                 160 


Ser Asp Ala Phe Gln Arg Lys Leu Glu Gly Cys Arg Phe Leu His Gly 
                165                 170                 175     


Tyr His Arg Phe Met His Ser Val Gly Arg Val Phe Ser Lys Trp Gly 
            180                 185                 190         


Glu Ser Pro Asn Arg Ser Arg Arg His Ser Pro His Gln Ala Leu Arg 
        195                 200                 205             


Lys Gly Val Arg Arg Thr Arg Pro Ser Arg Lys Gly Lys Arg Leu Met 
    210                 215                 220                 


Thr Arg Gly Gln Leu Pro Arg 
225                 230     


<210>  9854
<211>  20
<212>  PRT
<213>  Homo Sapiens

<400>  9854

Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Asn Thr Tyr Pro Arg 
1               5                   10                  15      


Pro Gly Cys Ser 
            20  


<210>  9855
<211>  252
<212>  PRT
<213>  Homo Sapiens

<400>  9855

Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala 
1               5                   10                  15      


Leu Leu Phe Pro Ser Met Ala Ser Met Ala Ala Ile Gly Ser Cys Ser 
            20                  25                  30          


Lys Glu Tyr Arg Val Leu Leu Gly Gln Leu Gln Lys Gln Thr Asp Leu 
        35                  40                  45              


Met Gln Asp Thr Ser Arg Leu Leu Asp Pro Tyr Ile Arg Ile Gln Gly 
    50                  55                  60                  


Leu Asp Val Pro Lys Leu Arg Glu His Cys Arg Glu Arg Pro Gly Ala 
65                  70                  75                  80  


Phe Pro Ser Glu Glu Thr Leu Arg Gly Leu Gly Arg Arg Gly Phe Leu 
                85                  90                  95      


Gln Thr Leu Asn Ala Thr Leu Gly Cys Val Leu His Arg Leu Ala Asp 
            100                 105                 110         


Leu Glu Gln Arg Leu Pro Lys Ala Gln Asp Leu Glu Arg Ser Gly Leu 
        115                 120                 125             


Asn Ile Glu Asp Leu Glu Lys Leu Gln Met Ala Arg Pro Asn Ile Leu 
    130                 135                 140                 


Gly Leu Arg Asn Asn Ile Tyr Cys Met Ala Gln Leu Leu Asp Asn Ser 
145                 150                 155                 160 


Asp Thr Ala Glu Pro Thr Lys Ala Gly Arg Gly Ala Ser Gln Pro Pro 
                165                 170                 175     


Thr Pro Thr Pro Ala Ser Asp Ala Phe Gln Arg Lys Leu Glu Gly Cys 
            180                 185                 190         


Arg Phe Leu His Gly Tyr His Arg Phe Met His Ser Val Gly Arg Val 
        195                 200                 205             


Phe Ser Lys Trp Gly Glu Ser Pro Asn Arg Ser Arg Arg His Ser Pro 
    210                 215                 220                 


His Gln Ala Leu Arg Lys Gly Val Arg Arg Thr Arg Pro Ser Arg Lys 
225                 230                 235                 240 


Gly Lys Arg Leu Met Thr Arg Gly Gln Leu Pro Arg 
                245                 250         


<210>  9856
<211>  188
<212>  PRT
<213>  Homo Sapiens

<400>  9856

Leu Glu Pro Ala Thr Glu Tyr Met Ala Arg Val Arg Cys Ala Asp Ala 
1               5                   10                  15      


Ser His Phe Trp Lys Trp Ser Glu Trp Ser Gly Gln Asn Phe Thr Thr 
            20                  25                  30          


Leu Glu Ala Ala Pro Ser Glu Ala Pro Asp Val Trp Arg Ile Val Ser 
        35                  40                  45              


Leu Glu Pro Gly Asn His Thr Val Thr Leu Phe Trp Lys Pro Leu Ser 
    50                  55                  60                  


Lys Leu His Ala Asn Gly Lys Ile Leu Phe Tyr Asn Val Val Val Glu 
65                  70                  75                  80  


Asn Leu Asp Lys Pro Ser Ser Ser Glu Leu His Ser Ile Pro Ala Pro 
                85                  90                  95      


Ala Asn Ser Thr Lys Leu Ile Leu Asp Arg Cys Ser Tyr Gln Ile Cys 
            100                 105                 110         


Val Ile Ala Asn Asn Ser Val Gly Ala Ser Pro Ala Ser Val Ile Val 
        115                 120                 125             


Ile Ser Ala Asp Pro Glu Asn Ser Val Ser Thr Cys Phe Ser Gly Thr 
    130                 135                 140                 


Val Pro Ser Val Trp Gly Glu Gly Asp Phe Ser His Gly Ser Gly His 
145                 150                 155                 160 


Phe Cys Pro Gly Asp Ser Ser Thr Tyr Met Gly Asn Tyr Leu Lys Phe 
                165                 170                 175     


Ile Gln Val Thr Ala Thr Leu Thr Asn Ser His His 
            180                 185             


<210>  9857
<211>  979
<212>  PRT
<213>  Homo Sapiens

<400>  9857

Met Ala Leu Phe Ala Val Phe Gln Thr Thr Phe Phe Leu Thr Leu Leu 
1               5                   10                  15      


Ser Leu Arg Thr Tyr Gln Ser Glu Val Leu Ala Glu Arg Leu Pro Leu 
            20                  25                  30          


Thr Pro Val Ser Leu Lys Val Ser Thr Asn Ser Thr Arg Gln Ser Leu 
        35                  40                  45              


His Leu Gln Trp Thr Val His Asn Leu Pro Tyr His Gln Glu Leu Lys 
    50                  55                  60                  


Met Val Phe Gln Ile Gln Ile Ser Arg Ile Glu Thr Ser Asn Val Ile 
65                  70                  75                  80  


Trp Val Gly Asn Tyr Ser Thr Thr Val Lys Trp Asn Gln Val Leu His 
                85                  90                  95      


Trp Ser Trp Glu Ser Glu Leu Pro Leu Glu Cys Ala Thr His Phe Val 
            100                 105                 110         


Arg Ile Lys Ser Leu Val Asp Asp Ala Lys Phe Pro Glu Pro Asn Phe 
        115                 120                 125             


Trp Ser Asn Trp Ser Ser Trp Glu Glu Val Ser Val Gln Asp Ser Thr 
    130                 135                 140                 


Gly Gln Asp Ile Leu Phe Val Phe Pro Lys Asp Lys Leu Val Glu Glu 
145                 150                 155                 160 


Gly Thr Asn Val Thr Ile Cys Tyr Val Ser Arg Asn Ile Gln Asn Asn 
                165                 170                 175     


Val Ser Cys Tyr Leu Glu Gly Lys Gln Ile His Gly Glu Gln Leu Asp 
            180                 185                 190         


Pro His Val Thr Ala Phe Asn Leu Asn Ser Val Pro Phe Ile Arg Asn 
        195                 200                 205             


Lys Gly Thr Asn Ile Tyr Cys Glu Ala Ser Gln Gly Asn Val Ser Glu 
    210                 215                 220                 


Gly Met Lys Gly Ile Val Leu Phe Val Ser Lys Val Leu Glu Glu Pro 
225                 230                 235                 240 


Lys Asp Phe Ser Cys Glu Thr Glu Asp Phe Lys Thr Leu His Cys Thr 
                245                 250                 255     


Trp Asp Pro Gly Thr Asp Thr Ala Leu Gly Trp Ser Lys Gln Pro Ser 
            260                 265                 270         


Gln Ser Tyr Thr Leu Phe Glu Ser Phe Ser Gly Glu Lys Lys Leu Cys 
        275                 280                 285             


Thr His Lys Asn Trp Cys Asn Trp Gln Ile Thr Gln Asp Ser Gln Glu 
    290                 295                 300                 


Thr Tyr Asn Phe Thr Leu Ile Ala Glu Asn Tyr Leu Arg Lys Arg Ser 
305                 310                 315                 320 


Val Asn Ile Leu Phe Asn Leu Thr His Arg Val Tyr Leu Met Asn Pro 
                325                 330                 335     


Phe Ser Val Asn Phe Glu Asn Val Asn Ala Thr Asn Ala Ile Met Thr 
            340                 345                 350         


Trp Lys Val His Ser Ile Arg Asn Asn Phe Thr Tyr Leu Cys Gln Ile 
        355                 360                 365             


Glu Leu His Gly Glu Gly Lys Met Met Gln Tyr Asn Val Ser Ile Lys 
    370                 375                 380                 


Val Asn Gly Glu Tyr Phe Leu Ser Glu Leu Glu Pro Ala Thr Glu Tyr 
385                 390                 395                 400 


Met Ala Arg Val Arg Cys Ala Asp Ala Ser His Phe Trp Lys Trp Ser 
                405                 410                 415     


Glu Trp Ser Gly Gln Asn Phe Thr Thr Leu Glu Ala Ala Pro Ser Glu 
            420                 425                 430         


Ala Pro Asp Val Trp Arg Ile Val Ser Leu Glu Pro Gly Asn His Thr 
        435                 440                 445             


Val Thr Leu Phe Trp Lys Pro Leu Ser Lys Leu His Ala Asn Gly Lys 
    450                 455                 460                 


Ile Leu Phe Tyr Asn Val Val Val Glu Asn Leu Asp Lys Pro Ser Ser 
465                 470                 475                 480 


Ser Glu Leu His Ser Ile Pro Ala Pro Ala Asn Ser Thr Lys Leu Ile 
                485                 490                 495     


Leu Asp Arg Cys Ser Tyr Gln Ile Cys Val Ile Ala Asn Asn Ser Val 
            500                 505                 510         


Gly Ala Ser Pro Ala Ser Val Ile Val Ile Ser Ala Asp Pro Glu Asn 
        515                 520                 525             


Lys Glu Val Glu Glu Glu Arg Ile Ala Gly Thr Glu Gly Gly Phe Ser 
    530                 535                 540                 


Leu Ser Trp Lys Pro Gln Pro Gly Asp Val Ile Gly Tyr Val Val Asp 
545                 550                 555                 560 


Trp Cys Asp His Thr Gln Asp Val Leu Gly Asp Phe Gln Trp Lys Asn 
                565                 570                 575     


Val Gly Pro Asn Thr Thr Ser Thr Val Ile Ser Thr Asp Ala Phe Arg 
            580                 585                 590         


Pro Gly Val Arg Tyr Asp Phe Arg Ile Tyr Gly Leu Ser Thr Lys Arg 
        595                 600                 605             


Ile Ala Cys Leu Leu Glu Lys Lys Thr Gly Tyr Ser Gln Glu Leu Ala 
    610                 615                 620                 


Pro Ser Asp Asn Pro His Val Leu Val Asp Thr Leu Thr Ser His Ser 
625                 630                 635                 640 


Phe Thr Leu Ser Trp Lys Asp Tyr Ser Thr Glu Ser Gln Pro Gly Phe 
                645                 650                 655     


Ile Gln Gly Tyr His Val Tyr Leu Lys Ser Lys Ala Arg Gln Cys His 
            660                 665                 670         


Pro Arg Phe Glu Lys Ala Val Leu Ser Asp Gly Ser Glu Cys Cys Lys 
        675                 680                 685             


Tyr Lys Ile Asp Asn Pro Glu Glu Lys Ala Leu Ile Val Asp Asn Leu 
    690                 695                 700                 


Lys Pro Glu Ser Phe Tyr Glu Phe Phe Ile Thr Pro Phe Thr Ser Ala 
705                 710                 715                 720 


Gly Glu Gly Pro Ser Ala Thr Phe Thr Lys Val Thr Thr Pro Asp Glu 
                725                 730                 735     


His Ser Ser Met Leu Ile His Ile Leu Leu Pro Met Val Phe Cys Val 
            740                 745                 750         


Leu Leu Ile Met Val Met Cys Tyr Leu Lys Ser Gln Trp Ile Lys Glu 
        755                 760                 765             


Thr Cys Tyr Pro Asp Ile Pro Asp Pro Tyr Lys Ser Ser Ile Leu Ser 
    770                 775                 780                 


Leu Ile Lys Phe Lys Glu Asn Pro His Leu Ile Ile Met Asn Val Ser 
785                 790                 795                 800 


Asp Cys Ile Pro Asp Ala Ile Glu Val Val Ser Lys Pro Glu Gly Thr 
                805                 810                 815     


Lys Ile Gln Phe Leu Gly Thr Arg Lys Ser Leu Thr Glu Thr Glu Leu 
            820                 825                 830         


Thr Lys Pro Asn Tyr Leu Tyr Leu Leu Pro Thr Glu Lys Asn His Ser 
        835                 840                 845             


Gly Pro Gly Pro Cys Ile Cys Phe Glu Asn Leu Thr Tyr Asn Gln Ala 
    850                 855                 860                 


Ala Ser Asp Ser Gly Ser Cys Gly His Val Pro Val Ser Pro Lys Ala 
865                 870                 875                 880 


Pro Ser Met Leu Gly Leu Met Thr Ser Pro Glu Asn Val Leu Lys Ala 
                885                 890                 895     


Leu Glu Lys Asn Tyr Met Asn Ser Leu Gly Glu Ile Pro Ala Gly Glu 
            900                 905                 910         


Thr Ser Leu Asn Tyr Val Ser Gln Leu Ala Ser Pro Met Phe Gly Asp 
        915                 920                 925             


Lys Asp Ser Leu Pro Thr Asn Pro Val Glu Ala Pro His Cys Ser Glu 
    930                 935                 940                 


Tyr Lys Met Gln Met Ala Val Ser Leu Arg Leu Ala Leu Pro Pro Pro 
945                 950                 955                 960 


Thr Glu Asn Ser Ser Leu Ser Ser Ile Thr Leu Leu Asp Pro Gly Glu 
                965                 970                 975     


His Tyr Cys 
            


<210>  9858
<211>  342
<212>  PRT
<213>  Homo Sapiens

<400>  9858

Met Ala Leu Phe Ala Val Phe Gln Thr Thr Phe Phe Leu Thr Leu Leu 
1               5                   10                  15      


Ser Leu Arg Thr Tyr Gln Ser Glu Val Leu Ala Glu Arg Leu Pro Leu 
            20                  25                  30          


Thr Pro Val Ser Leu Lys Val Ser Thr Asn Ser Thr Arg Gln Ser Leu 
        35                  40                  45              


His Leu Gln Trp Thr Val His Asn Leu Pro Tyr His Gln Glu Leu Lys 
    50                  55                  60                  


Met Val Phe Gln Ile Gln Ile Ser Arg Ile Glu Thr Ser Asn Val Ile 
65                  70                  75                  80  


Trp Val Gly Asn Tyr Ser Thr Thr Val Lys Trp Asn Gln Val Leu His 
                85                  90                  95      


Trp Ser Trp Glu Ser Glu Leu Pro Leu Glu Cys Ala Thr His Phe Val 
            100                 105                 110         


Arg Ile Lys Ser Leu Val Asp Asp Ala Lys Phe Pro Glu Pro Asn Phe 
        115                 120                 125             


Trp Ser Asn Trp Ser Ser Trp Glu Glu Val Ser Val Gln Asp Ser Thr 
    130                 135                 140                 


Gly Gln Asp Ile Leu Phe Val Phe Pro Lys Asp Lys Leu Val Glu Glu 
145                 150                 155                 160 


Gly Thr Asn Val Thr Ile Cys Tyr Val Ser Arg Asn Ile Gln Asn Asn 
                165                 170                 175     


Val Ser Cys Tyr Leu Glu Gly Lys Gln Ile His Gly Glu Gln Leu Asp 
            180                 185                 190         


Pro His Val Thr Ala Phe Asn Leu Asn Ser Val Pro Phe Ile Arg Asn 
        195                 200                 205             


Lys Gly Thr Asn Ile Tyr Cys Glu Ala Ser Gln Gly Asn Val Ser Glu 
    210                 215                 220                 


Gly Met Lys Gly Ile Val Leu Phe Val Ser Lys Val Leu Glu Glu Pro 
225                 230                 235                 240 


Lys Asp Phe Ser Cys Glu Thr Glu Asp Phe Lys Thr Leu His Cys Thr 
                245                 250                 255     


Trp Asp Pro Gly Thr Asp Thr Ala Leu Gly Trp Ser Lys Gln Pro Ser 
            260                 265                 270         


Gln Ser Tyr Thr Leu Phe Glu Ser Phe Ser Gly Glu Lys Lys Leu Cys 
        275                 280                 285             


Thr His Lys Asn Trp Cys Asn Trp Gln Ile Thr Gln Asp Ser Gln Glu 
    290                 295                 300                 


Thr Tyr Asn Phe Thr Leu Ile Ala Glu Asn Tyr Leu Arg Lys Arg Ser 
305                 310                 315                 320 


Val Asn Ile Leu Phe Asn Leu Thr His Arg Gly Glu Thr Arg Val Val 
                325                 330                 335     


Thr Ala His Arg Gly His 
            340         


<210>  9859
<211>  35
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9859

Xaa Ile Lys Glu Thr Cys Tyr Pro Asp Ile Pro Asp Pro Tyr Lys Ser 
1               5                   10                  15      


Ser Ile Leu Ser Leu Ile Lys Phe Lys Ile Ser Ser Lys Val Trp Leu 
            20                  25                  30          


Asn Arg Arg 
        35  


<210>  9860
<211>  62
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9860

Xaa Ser Met Leu Ile His Ile Leu Leu Pro Met Val Phe Cys Val Leu 
1               5                   10                  15      


Leu Ile Met Val Met Cys Tyr Leu Lys Ser Gln Trp Ile Lys Glu Thr 
            20                  25                  30          


Cys Tyr Pro Asp Ile Pro Asp Pro Tyr Lys Ser Ser Ile Leu Ser Leu 
        35                  40                  45              


Ile Lys Phe Lys Ile Ser Ser Lys Val Trp Leu Asn Arg Arg 
    50                  55                  60          


<210>  9861
<211>  111
<212>  PRT
<213>  Homo Sapiens

<400>  9861

Met Leu Asp Trp Arg Leu Ala Ser Ala His Phe Ile Leu Ala Val Thr 
1               5                   10                  15      


Leu Thr Leu Trp Ser Ser Gly Lys Val Leu Ser Val Asp Val Thr Thr 
            20                  25                  30          


Thr Glu Ala Phe Asp Ser Gly Val Ile Asp Val Gln Ser Thr Pro Thr 
        35                  40                  45              


Val Arg Glu Glu Lys Ser Ala Thr Asp Leu Thr Ala Lys Leu Leu Leu 
    50                  55                  60                  


Leu Asp Glu Leu Val Ser Leu Glu Asn Asp Val Ile Glu Thr Lys Lys 
65                  70                  75                  80  


Lys Arg Ser Phe Ser Gly Phe Gly Ser Pro Leu Asp Arg Leu Ser Ala 
                85                  90                  95      


Gly Ser Val Asp His Lys Gly Lys Gln Arg Cys Asn Phe Leu Gly 
            100                 105                 110     


<210>  9862
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  9862

Met Leu Asp Trp Arg Leu Ala Ser Ala His Phe Ile Leu Ala Val Thr 
1               5                   10                  15      


Leu Thr Leu Trp Ser Ser Gly Lys Val Leu Ser Val Asp Val Thr Thr 
            20                  25                  30          


Thr Glu Ala Phe Asp Ser Gly Val Ile Asp Val Gln Ser Thr Pro Thr 
        35                  40                  45              


Val Arg Glu Glu Lys Ser Ala Thr Asp Leu Thr Ala Lys Leu Leu Leu 
    50                  55                  60                  


Leu Asp Glu Leu Val Ser Leu Glu Asn Asp Val Ile Glu Thr Lys Lys 
65                  70                  75                  80  


Lys Arg Ser Phe Ser Gly Phe Gly Ser Pro Leu Asp Arg Leu Ser Ala 
                85                  90                  95      


Gly Ser Val Asp His Lys Gly Lys Gln Arg Lys Val Val Asp His Pro 
            100                 105                 110         


Lys Arg Arg Phe Gly Ile Pro Met Asp Arg Ile Gly Arg Asn Arg Leu 
        115                 120                 125             


Ser Asn Ser Arg Gly 
    130             


<210>  9863
<211>  815
<212>  PRT
<213>  Homo Sapiens

<400>  9863

Met Phe Arg Leu Gly Leu Leu Val Cys Phe Tyr Asn Asp Leu Glu Leu 
1               5                   10                  15      


Leu Asp Ala Thr Val Ala Gln Val Leu Leu Tyr Gln Met Ile Lys Cys 
            20                  25                  30          


Ser His Leu Arg Gly Phe Gln Ala Gly Val Gln Lys Leu Lys Ala Glu 
        35                  40                  45              


Leu Leu Asp Ile Ala Met Glu Asn Gln Thr Leu Asn Glu Thr Leu Gly 
    50                  55                  60                  


Ser Leu Ser Asp Ala Val Val Gly Leu Thr Tyr Ser Gln Leu Glu Ser 
65                  70                  75                  80  


Leu Ser Pro Glu Ala Val His Gly Ala Ile Ser Thr Leu Asn Gln Val 
                85                  90                  95      


Ser Gly Trp Ala Lys Ser Gln Val Ile Ile Leu Ser Ala Lys Tyr Leu 
            100                 105                 110         


Ala His Glu Lys Val Leu Ser Phe Tyr Asn Val Ser Gln Met Gly Ala 
        115                 120                 125             


Leu Leu Ala Gly Val Ser Thr Gln Ala Phe Cys Ser Met Lys Arg Lys 
    130                 135                 140                 


Asp Ile Ser Gln Val Leu Arg Ser Ala Val Ser Gln Tyr Val Ser Asp 
145                 150                 155                 160 


Leu Ser Pro Ala Gln Gln Gln Gly Ile Leu Ser Lys Met Val Gln Ala 
                165                 170                 175     


Glu Asp Thr Ala Pro Gly Ile Val Glu Ile Gln Gly Ala Phe Phe Lys 
            180                 185                 190         


Glu Val Ser Leu Phe Asp Leu Arg Arg Gln Pro Gly Phe Asn Ser Thr 
        195                 200                 205             


Val Leu Lys Asp Lys Glu Leu Gly Arg Ser Gln Ala Leu Phe Leu Tyr 
    210                 215                 220                 


Glu Leu Leu Leu Lys Thr Thr Arg Arg Pro Glu Glu Leu Leu Ser Ala 
225                 230                 235                 240 


Gly Gln Leu Val Lys Gly Val Thr Cys Ser His Ile Asp Ala Met Ser 
                245                 250                 255     


Thr Asp Phe Phe Leu Ala His Phe Gln Asp Phe Gln Asn Asn Phe Ala 
            260                 265                 270         


Leu Leu Ser Pro Tyr Gln Val Asn Cys Leu Ala Trp Lys Tyr Trp Glu 
        275                 280                 285             


Val Ser Arg Leu Ser Met Pro Pro Phe Leu Leu Ala Ala Leu Pro Ala 
    290                 295                 300                 


Arg Tyr Leu Ala Ser Val Pro Ala Ser Gln Cys Val Pro Phe Leu Ile 
305                 310                 315                 320 


Ser Leu Gly Lys Ser Trp Leu Asp Ser Leu Val Leu Asp Ser His Lys 
                325                 330                 335     


Lys Thr Ser Val Leu Arg Lys Val Gln Gln Cys Leu Asp Asp Ser Ile 
            340                 345                 350         


Ala Asp Glu Tyr Thr Val Asp Ile Met Gly Asn Leu Leu Cys His Leu 
        355                 360                 365             


Pro Ala Ala Ile Ile Asp Arg Gly Ile Ser Pro Arg Ala Trp Ala Thr 
    370                 375                 380                 


Ala Leu His Gly Leu Arg Asp Cys Pro Asp Leu Asn Pro Glu Gln Lys 
385                 390                 395                 400 


Ala Ala Val Arg Leu Lys Leu Leu Gly Gln Tyr Gly Leu Pro Gln His 
                405                 410                 415     


Trp Thr Ala Glu Thr Thr Lys Asp Leu Gly Pro Phe Leu Val Leu Phe 
            420                 425                 430         


Ser Gly Asp Glu Leu Ser Ser Ile Ala Thr Lys Phe Pro Glu Ile Leu 
        435                 440                 445             


Leu Gln Ala Ala Ser Lys Met Ala Arg Thr Leu Pro Thr Lys Glu Phe 
    450                 455                 460                 


Leu Trp Ala Val Phe Gln Ser Val Arg Asn Ser Ser Asp Lys Ile Pro 
465                 470                 475                 480 


Ser Tyr Asp Pro Met Pro Gly Cys His Gly Val Val Ala Pro Ser Ser 
                485                 490                 495     


Asp Asp Ile Phe Lys Leu Ala Glu Ala Asn Ala Cys Trp Ala Leu Glu 
            500                 505                 510         


Asp Leu Arg Cys Met Glu Glu Asp Thr Phe Ile Arg Thr Val Glu Leu 
        515                 520                 525             


Leu Gly Ala Val Gln Gly Phe Ser Arg Pro Gln Leu Met Thr Leu Lys 
    530                 535                 540                 


Glu Lys Ala Ile Gln Val Trp Asp Met Pro Ser Tyr Trp Arg Glu His 
545                 550                 555                 560 


His Ile Val Ser Leu Gly Arg Ile Ala Leu Ala Leu Asn Glu Ser Glu 
                565                 570                 575     


Leu Glu Gln Leu Asp Leu Ser Ser Ile Asp Thr Val Ala Ser Leu Ser 
            580                 585                 590         


Trp Gln Thr Glu Trp Thr Pro Gly Gln Ala Glu Ser Ile Leu Gln Gly 
        595                 600                 605             


Tyr Leu Asp Asp Ser Gly Tyr Ser Ile Gln Asp Leu Lys Ser Phe His 
    610                 615                 620                 


Leu Val Gly Leu Gly Ala Thr Leu Cys Ala Ile Asn Ile Thr Glu Ile 
625                 630                 635                 640 


Pro Leu Ile Lys Ile Ser Glu Phe Arg Val Val Val Ala Arg Ile Gly 
                645                 650                 655     


Thr Leu Leu Cys Ser Thr His Val Leu Ala Glu Phe Lys Arg Lys Ala 
            660                 665                 670         


Glu Val Val Phe Gly Asp Pro Thr Glu Trp Thr Ser Ser Val Leu Gln 
        675                 680                 685             


Glu Leu Gly Thr Ile Ala Ala Gly Leu Thr Lys Ala Glu Leu Arg Met 
    690                 695                 700                 


Leu Asp Lys Asp Leu Met Pro Tyr Phe Gln Pro Ser Ala Ile Lys Cys 
705                 710                 715                 720 


Leu Pro Asp Glu Ile Phe Lys Glu Leu Ser Ala Glu Gln Ile Ala Ser 
                725                 730                 735     


Leu Gly Pro Glu Asn Ala Ala Ala Val Thr His Ala Gln Arg Arg Arg 
            740                 745                 750         


Leu Ser Pro Leu Gln Leu Gln Ser Leu Gln Gln Ala Leu Asp Gly Ala 
        755                 760                 765             


Lys Thr His Ser Trp Gln Asp Ala Pro Ala Ser Ala Gly Pro Thr Arg 
    770                 775                 780                 


Thr Ser Ser Ser Arg Ser Pro Ala Gly Ala Leu Gln Ser Trp Gly Leu 
785                 790                 795                 800 


Trp Leu Gly Cys Pro Leu Leu Val Leu Met Ala Lys Leu Leu Trp 
                805                 810                 815 


<210>  9864
<211>  1060
<212>  PRT
<213>  Homo Sapiens

<400>  9864

Met Gly Asn Ser Ile Thr Tyr Arg Asp Gln Ala Ala Val Glu Asn His 
1               5                   10                  15      


Leu Glu Gln Arg Leu His Gln Pro Gln Lys Leu Leu Glu Asp Leu Arg 
            20                  25                  30          


Lys Thr Asp Ala Gln Gln Phe Arg Thr Ala Met Lys Cys Leu Leu Glu 
        35                  40                  45              


Asp Lys Lys Asp Gly Leu Asp Leu Lys Asp Ile Ile Ile Asp Leu Gly 
    50                  55                  60                  


Glu Ile Arg Glu Arg Ala Leu Gln Ser Pro Gly Val Asn Arg Ser Leu 
65                  70                  75                  80  


Phe Leu Ile Thr Leu Glu Arg Cys Phe Gln Met Leu Asn Ser Leu Glu 
                85                  90                  95      


Cys Val Glu Ile Leu Gly Lys Val Leu Arg Gly Ser Ser Gly Ser Phe 
            100                 105                 110         


Leu Gln Pro Asp Ile Thr Glu Arg Leu Pro Arg Asp Leu Arg Glu Asp 
        115                 120                 125             


Ala Phe Lys Asn Leu Ser Ala Val Phe Lys Asp Leu Tyr Asp Lys Thr 
    130                 135                 140                 


Ser Ala His Ser Gln Arg Ala Leu Tyr Ser Trp Met Thr Gly Ile Leu 
145                 150                 155                 160 


Gln Thr Ser Ser Asn Ala Thr Asp Asp Ser Ala Ser Trp Val Ser Ala 
                165                 170                 175     


Glu His Leu Trp Val Leu Gly Arg Tyr Met Val His Leu Ser Phe Glu 
            180                 185                 190         


Glu Ile Thr Lys Ile Ser Pro Ile Glu Ile Gly Leu Phe Ile Ser Tyr 
        195                 200                 205             


Asp Asn Ala Thr Lys Gln Leu Asp Met Val Tyr Asp Ile Thr Pro Glu 
    210                 215                 220                 


Leu Ala Gln Ala Phe Leu Glu Arg Ile Ser Ser Ser Asn Phe Asn Met 
225                 230                 235                 240 


Arg Asn Thr Ser Thr Ile His Arg Leu Gly Leu Leu Val Cys Phe Tyr 
                245                 250                 255     


Asn Asp Leu Glu Leu Leu Asp Ala Thr Val Ala Gln Val Leu Leu Tyr 
            260                 265                 270         


Gln Met Ile Lys Cys Ser His Leu Arg Gly Phe Gln Ala Gly Val Gln 
        275                 280                 285             


Lys Leu Lys Ala Glu Leu Leu Asp Ile Ala Met Glu Asn Gln Thr Leu 
    290                 295                 300                 


Asn Glu Thr Leu Gly Ser Leu Ser Asp Ala Val Val Gly Leu Thr Tyr 
305                 310                 315                 320 


Ser Gln Leu Glu Ser Leu Ser Pro Glu Ala Val His Gly Ala Ile Ser 
                325                 330                 335     


Thr Leu Asn Gln Val Ser Gly Trp Ala Lys Ser Gln Val Ile Ile Leu 
            340                 345                 350         


Ser Ala Lys Tyr Leu Ala His Glu Lys Val Leu Ser Phe Tyr Asn Val 
        355                 360                 365             


Ser Gln Met Gly Ala Leu Leu Ala Gly Val Ser Thr Gln Ala Phe Cys 
    370                 375                 380                 


Ser Met Lys Arg Lys Asp Ile Ser Gln Val Leu Arg Ser Ala Val Ser 
385                 390                 395                 400 


Gln Tyr Val Ser Asp Leu Ser Pro Ala Gln Gln Gln Gly Ile Leu Ser 
                405                 410                 415     


Lys Met Val Gln Ala Glu Asp Thr Ala Pro Gly Ile Val Glu Ile Gln 
            420                 425                 430         


Gly Ala Phe Phe Lys Glu Val Ser Leu Phe Asp Leu Arg Arg Gln Pro 
        435                 440                 445             


Gly Phe Asn Ser Thr Val Leu Lys Asp Lys Glu Leu Gly Arg Ser Gln 
    450                 455                 460                 


Ala Leu Phe Leu Tyr Glu Leu Leu Leu Lys Thr Thr Arg Arg Pro Glu 
465                 470                 475                 480 


Glu Leu Leu Ser Ala Gly Gln Leu Val Lys Gly Val Thr Cys Ser His 
                485                 490                 495     


Ile Asp Ala Met Ser Thr Asp Phe Phe Leu Ala His Phe Gln Asp Phe 
            500                 505                 510         


Gln Asn Asn Phe Ala Leu Leu Ser Pro Tyr Gln Val Asn Cys Leu Ala 
        515                 520                 525             


Trp Lys Tyr Trp Glu Val Ser Arg Leu Ser Met Pro Pro Phe Leu Leu 
    530                 535                 540                 


Ala Ala Leu Pro Ala Arg Tyr Leu Ala Ser Val Pro Ala Ser Gln Cys 
545                 550                 555                 560 


Val Pro Phe Leu Ile Ser Leu Gly Lys Ser Trp Leu Asp Ser Leu Val 
                565                 570                 575     


Leu Asp Ser His Lys Lys Thr Ser Val Leu Arg Lys Val Gln Gln Cys 
            580                 585                 590         


Leu Asp Asp Ser Ile Ala Asp Glu Tyr Thr Val Asp Ile Met Gly Asn 
        595                 600                 605             


Leu Leu Cys His Leu Pro Ala Ala Ile Ile Asp Arg Gly Ile Ser Pro 
    610                 615                 620                 


Arg Ala Trp Ala Thr Ala Leu His Gly Leu Arg Asp Cys Pro Asp Leu 
625                 630                 635                 640 


Asn Pro Glu Gln Lys Ala Ala Val Arg Leu Lys Leu Leu Gly Gln Tyr 
                645                 650                 655     


Gly Leu Pro Gln His Trp Thr Ala Glu Thr Thr Lys Asp Leu Gly Pro 
            660                 665                 670         


Phe Leu Val Leu Phe Ser Gly Asp Glu Leu Ser Ser Ile Ala Thr Lys 
        675                 680                 685             


Phe Pro Glu Ile Leu Leu Gln Ala Ala Ser Lys Met Ala Arg Thr Leu 
    690                 695                 700                 


Pro Thr Lys Glu Phe Leu Trp Ala Val Phe Gln Ser Val Arg Asn Ser 
705                 710                 715                 720 


Ser Asp Lys Ile Pro Ser Tyr Asp Pro Met Pro Gly Cys His Gly Val 
                725                 730                 735     


Val Ala Pro Ser Ser Asp Asp Ile Phe Lys Leu Ala Glu Ala Asn Ala 
            740                 745                 750         


Cys Trp Ala Leu Glu Asp Leu Arg Cys Met Glu Glu Asp Thr Phe Ile 
        755                 760                 765             


Arg Thr Val Glu Leu Leu Gly Ala Val Gln Gly Phe Ser Arg Pro Gln 
    770                 775                 780                 


Leu Met Thr Leu Lys Glu Lys Ala Ile Gln Val Trp Asp Met Pro Ser 
785                 790                 795                 800 


Tyr Trp Arg Glu His His Ile Val Ser Leu Gly Arg Ile Ala Leu Ala 
                805                 810                 815     


Leu Asn Glu Ser Glu Leu Glu Gln Leu Asp Leu Ser Ser Ile Asp Thr 
            820                 825                 830         


Val Ala Ser Leu Ser Trp Gln Thr Glu Trp Thr Pro Gly Gln Ala Glu 
        835                 840                 845             


Ser Ile Leu Gln Gly Tyr Leu Asp Asp Ser Gly Tyr Ser Ile Gln Asp 
    850                 855                 860                 


Leu Lys Ser Phe His Leu Val Gly Leu Gly Ala Thr Leu Cys Ala Ile 
865                 870                 875                 880 


Asn Ile Thr Glu Ile Pro Leu Ile Lys Ile Ser Glu Phe Arg Val Val 
                885                 890                 895     


Val Ala Arg Ile Gly Thr Leu Leu Cys Ser Thr His Val Leu Ala Glu 
            900                 905                 910         


Phe Lys Arg Lys Ala Glu Val Val Phe Gly Asp Pro Thr Glu Trp Thr 
        915                 920                 925             


Ser Ser Val Leu Gln Glu Leu Gly Thr Ile Ala Ala Gly Leu Thr Lys 
    930                 935                 940                 


Ala Glu Leu Arg Met Leu Asp Lys Asp Leu Met Pro Tyr Phe Gln Pro 
945                 950                 955                 960 


Ser Ala Ile Lys Cys Leu Pro Asp Glu Ile Phe Lys Glu Leu Ser Ala 
                965                 970                 975     


Glu Gln Ile Ala Ser Leu Gly Pro Glu Asn Ala Ala Ala Val Thr His 
            980                 985                 990         


Ala Gln Arg Arg Arg Leu Ser Pro  Leu Gln Leu Gln Ser  Leu Gln Gln 
        995                 1000                 1005             


Ala Leu  Asp Gly Ala Lys Thr  His Ser Trp Gln Asp  Ala Pro Ala 
    1010                 1015                 1020             


Ser Ala  Gly Pro Thr Arg Thr  Ser Ser Ser Arg Ser  Pro Ala Gly 
    1025                 1030                 1035             


Ala Leu  Gln Ser Trp Gly Leu  Trp Leu Gly Cys Pro  Leu Leu Val 
    1040                 1045                 1050             


Leu Met  Ala Lys Leu Leu Trp  
    1055                 1060 


<210>  9865
<211>  1153
<212>  PRT
<213>  Homo Sapiens

<400>  9865

Met Ser Gln Glu Pro Thr Thr Tyr Ser Leu Phe Leu Phe Leu Phe Leu 
1               5                   10                  15      


Ser His Gly Val Ser Ser Tyr Thr Val Pro Asn Ser Arg Gln Asp Leu 
            20                  25                  30          


His Pro Leu Leu Gln Asn Met Ala Glu Glu Ile Ile Asp Gly Ser Tyr 
        35                  40                  45              


Leu Asn Ala Leu Leu Asp Leu Ile Gln Phe Gln Ser Ser His Val Trp 
    50                  55                  60                  


Thr Asp Asp Leu Ser His Arg Val Leu Ala Tyr Leu Asn Ser Arg Asn 
65                  70                  75                  80  


Val Ala Phe Thr Ile Pro Ser Leu Gln Ala Ala Val Glu Asn His Leu 
                85                  90                  95      


Glu Gln Arg Leu His Gln Pro Gln Lys Leu Leu Glu Asp Leu Arg Lys 
            100                 105                 110         


Thr Asp Ala Gln Gln Phe Arg Thr Ala Met Lys Cys Leu Leu Glu Asp 
        115                 120                 125             


Lys Lys Asp Gly Leu Asp Leu Lys Asp Ile Ile Ile Asp Leu Gly Glu 
    130                 135                 140                 


Ile Arg Glu Arg Ala Leu Gln Ser Pro Gly Val Asn Arg Ser Leu Phe 
145                 150                 155                 160 


Leu Ile Thr Leu Glu Arg Cys Phe Gln Met Leu Asn Ser Leu Glu Cys 
                165                 170                 175     


Val Glu Ile Leu Gly Lys Val Leu Arg Gly Ser Ser Gly Ser Phe Leu 
            180                 185                 190         


Gln Pro Asp Ile Thr Glu Arg Leu Pro Arg Asp Leu Arg Glu Asp Ala 
        195                 200                 205             


Phe Lys Asn Leu Ser Ala Val Phe Lys Asp Leu Tyr Asp Lys Thr Ser 
    210                 215                 220                 


Ala His Ser Gln Arg Ala Leu Tyr Ser Trp Met Thr Gly Ile Leu Gln 
225                 230                 235                 240 


Thr Ser Ser Asn Ala Thr Asp Asp Ser Ala Ser Trp Val Ser Ala Glu 
                245                 250                 255     


His Leu Trp Val Leu Gly Arg Tyr Met Val His Leu Ser Phe Glu Glu 
            260                 265                 270         


Ile Thr Lys Ile Ser Pro Ile Glu Ile Gly Leu Phe Ile Ser Tyr Asp 
        275                 280                 285             


Asn Ala Thr Lys Gln Leu Asp Met Val Tyr Asp Ile Thr Pro Glu Leu 
    290                 295                 300                 


Ala Gln Ala Phe Leu Glu Arg Ile Ser Ser Ser Asn Phe Asn Met Arg 
305                 310                 315                 320 


Asn Thr Ser Thr Ile His Arg Gln Ala His Glu Leu Trp Ala Leu Glu 
                325                 330                 335     


Pro Phe Pro Lys Met Leu Gly Leu Leu Val Cys Phe Tyr Asn Asp Leu 
            340                 345                 350         


Glu Leu Leu Asp Ala Thr Val Ala Gln Val Leu Leu Tyr Gln Met Ile 
        355                 360                 365             


Lys Cys Ser His Leu Arg Gly Phe Gln Ala Gly Val Gln Lys Leu Lys 
    370                 375                 380                 


Ala Glu Leu Leu Asp Ile Ala Met Glu Asn Gln Thr Leu Asn Glu Thr 
385                 390                 395                 400 


Leu Gly Ser Leu Ser Asp Ala Val Val Gly Leu Thr Tyr Ser Gln Leu 
                405                 410                 415     


Glu Ser Leu Ser Pro Glu Ala Val His Gly Ala Ile Ser Thr Leu Asn 
            420                 425                 430         


Gln Val Ser Gly Trp Ala Lys Ser Gln Val Ile Ile Leu Ser Ala Lys 
        435                 440                 445             


Tyr Leu Ala His Glu Lys Val Leu Ser Phe Tyr Asn Val Ser Gln Met 
    450                 455                 460                 


Gly Ala Leu Leu Ala Gly Val Ser Thr Gln Ala Phe Cys Ser Met Lys 
465                 470                 475                 480 


Arg Lys Asp Ile Ser Gln Val Leu Arg Ser Ala Val Ser Gln Tyr Val 
                485                 490                 495     


Ser Asp Leu Ser Pro Ala Gln Gln Gln Gly Ile Leu Ser Lys Met Val 
            500                 505                 510         


Gln Ala Glu Asp Thr Ala Pro Gly Ile Val Glu Ile Gln Gly Ala Phe 
        515                 520                 525             


Phe Lys Glu Val Ser Leu Phe Asp Leu Arg Arg Gln Pro Gly Phe Asn 
    530                 535                 540                 


Ser Thr Val Leu Lys Asp Lys Glu Leu Gly Arg Ser Gln Ala Leu Phe 
545                 550                 555                 560 


Leu Tyr Glu Leu Leu Leu Lys Thr Thr Arg Arg Pro Glu Glu Leu Leu 
                565                 570                 575     


Ser Ala Gly Gln Leu Val Lys Gly Val Thr Cys Ser His Ile Asp Ala 
            580                 585                 590         


Met Ser Thr Asp Phe Phe Leu Ala His Phe Gln Asp Phe Gln Asn Asn 
        595                 600                 605             


Phe Ala Leu Leu Ser Pro Tyr Gln Val Asn Cys Leu Ala Trp Lys Tyr 
    610                 615                 620                 


Trp Glu Val Ser Arg Leu Ser Met Pro Pro Phe Leu Leu Ala Ala Leu 
625                 630                 635                 640 


Pro Ala Arg Tyr Leu Ala Ser Val Pro Ala Ser Gln Cys Val Pro Phe 
                645                 650                 655     


Leu Ile Ser Leu Gly Lys Ser Trp Leu Asp Ser Leu Val Leu Asp Ser 
            660                 665                 670         


His Lys Lys Thr Ser Val Leu Arg Lys Val Gln Gln Cys Leu Asp Asp 
        675                 680                 685             


Ser Ile Ala Asp Glu Tyr Thr Val Asp Ile Met Gly Asn Leu Leu Cys 
    690                 695                 700                 


His Leu Pro Ala Ala Ile Ile Asp Arg Gly Ile Ser Pro Arg Ala Trp 
705                 710                 715                 720 


Ala Thr Ala Leu His Gly Leu Arg Asp Cys Pro Asp Leu Asn Pro Glu 
                725                 730                 735     


Gln Lys Ala Ala Val Arg Leu Lys Leu Leu Gly Gln Tyr Gly Leu Pro 
            740                 745                 750         


Gln His Trp Thr Ala Glu Thr Thr Lys Asp Leu Gly Pro Phe Leu Val 
        755                 760                 765             


Leu Phe Ser Gly Asp Glu Leu Ser Ser Ile Ala Thr Lys Phe Pro Glu 
    770                 775                 780                 


Ile Leu Leu Gln Ala Ala Ser Lys Met Ala Arg Thr Leu Pro Thr Lys 
785                 790                 795                 800 


Glu Phe Leu Trp Ala Val Phe Gln Ser Val Arg Asn Ser Ser Asp Lys 
                805                 810                 815     


Ile Pro Ser Tyr Asp Pro Met Pro Gly Cys His Gly Val Val Ala Pro 
            820                 825                 830         


Ser Ser Asp Asp Ile Phe Lys Leu Ala Glu Ala Asn Ala Cys Trp Ala 
        835                 840                 845             


Leu Glu Asp Leu Arg Cys Met Glu Glu Asp Thr Phe Ile Arg Thr Val 
    850                 855                 860                 


Glu Leu Leu Gly Ala Val Gln Gly Phe Ser Arg Pro Gln Leu Met Thr 
865                 870                 875                 880 


Leu Lys Glu Lys Ala Ile Gln Val Trp Asp Met Pro Ser Tyr Trp Arg 
                885                 890                 895     


Glu His His Ile Val Ser Leu Gly Arg Ile Ala Leu Ala Leu Asn Glu 
            900                 905                 910         


Ser Glu Leu Glu Gln Leu Asp Leu Ser Ser Ile Asp Thr Val Ala Ser 
        915                 920                 925             


Leu Ser Trp Gln Thr Glu Trp Thr Pro Gly Gln Ala Glu Ser Ile Leu 
    930                 935                 940                 


Gln Gly Tyr Leu Asp Asp Ser Gly Tyr Ser Ile Gln Asp Leu Lys Ser 
945                 950                 955                 960 


Phe His Leu Val Gly Leu Gly Ala Thr Leu Cys Ala Ile Asn Ile Thr 
                965                 970                 975     


Glu Ile Pro Leu Ile Lys Ile Ser Glu Phe Arg Val Val Val Ala Arg 
            980                 985                 990         


Ile Gly Thr Leu Leu Cys Ser Thr  His Val Leu Ala Glu  Phe Lys Arg 
        995                 1000                 1005             


Lys Ala  Glu Val Val Phe Gly  Asp Pro Thr Glu Trp  Thr Ser Ser 
    1010                 1015                 1020             


Val Leu  Gln Glu Leu Gly Thr  Ile Ala Ala Gly Leu  Thr Lys Ala 
    1025                 1030                 1035             


Glu Leu  Arg Met Leu Asp Lys  Asp Leu Met Pro Tyr  Phe Gln Pro 
    1040                 1045                 1050             


Ser Ala  Ile Lys Cys Leu Pro  Asp Glu Ile Phe Lys  Glu Leu Ser 
    1055                 1060                 1065             


Ala Glu  Gln Ile Ala Ser Leu  Gly Pro Glu Asn Ala  Ala Ala Val 
    1070                 1075                 1080             


Thr His  Ala Gln Arg Arg Arg  Leu Ser Pro Leu Gln  Leu Gln Ser 
    1085                 1090                 1095             


Leu Gln  Gln Ala Leu Asp Gly  Ala Lys Thr His Ser  Trp Gln Asp 
    1100                 1105                 1110             


Ala Pro  Ala Ser Ala Gly Pro  Thr Arg Thr Ser Ser  Ser Arg Ser 
    1115                 1120                 1125             


Pro Ala  Gly Ala Leu Gln Ser  Trp Gly Leu Trp Leu  Gly Cys Pro 
    1130                 1135                 1140             


Leu Leu  Val Leu Met Ala Lys  Leu Leu Trp 
    1145                 1150             


<210>  9866
<211>  1139
<212>  PRT
<213>  Homo Sapiens

<400>  9866

Met Ser Gln Glu Pro Thr Thr Tyr Ser Leu Phe Leu Phe Leu Phe Leu 
1               5                   10                  15      


Ser His Gly Val Ser Ser Tyr Thr Val Pro Asn Ser Arg Gln Asp Leu 
            20                  25                  30          


His Pro Leu Leu Gln Asn Met Ala Glu Glu Ile Ile Asp Gly Ser Tyr 
        35                  40                  45              


Leu Asn Ala Leu Leu Asp Leu Ile Gln Phe Gln Ser Ser His Val Trp 
    50                  55                  60                  


Thr Asp Asp Leu Ser His Arg Val Leu Ala Tyr Leu Asn Ser Arg Asn 
65                  70                  75                  80  


Val Ala Phe Thr Ile Pro Ser Leu Gln Ala Ala Val Glu Asn His Leu 
                85                  90                  95      


Glu Gln Arg Leu His Gln Pro Gln Lys Leu Leu Glu Asp Leu Arg Lys 
            100                 105                 110         


Thr Asp Ala Gln Gln Phe Arg Thr Ala Met Lys Cys Leu Leu Glu Asp 
        115                 120                 125             


Lys Lys Asp Gly Leu Asp Leu Lys Asp Ile Ile Ile Asp Leu Gly Glu 
    130                 135                 140                 


Ile Arg Glu Arg Ala Leu Gln Ser Pro Gly Val Asn Arg Ser Leu Phe 
145                 150                 155                 160 


Leu Ile Thr Leu Glu Arg Cys Phe Gln Met Leu Asn Ser Leu Glu Cys 
                165                 170                 175     


Val Glu Ile Leu Gly Lys Val Leu Arg Gly Ser Ser Gly Ser Phe Leu 
            180                 185                 190         


Gln Pro Asp Ile Thr Glu Arg Leu Pro Arg Asp Leu Arg Glu Asp Ala 
        195                 200                 205             


Phe Lys Asn Leu Ser Ala Val Phe Lys Asp Leu Tyr Asp Lys Thr Ser 
    210                 215                 220                 


Ala His Ser Gln Arg Ala Leu Tyr Ser Trp Met Thr Gly Ile Leu Gln 
225                 230                 235                 240 


Thr Ser Ser Asn Ala Thr Asp Asp Ser Ala Ser Trp Val Ser Ala Glu 
                245                 250                 255     


His Leu Trp Val Leu Gly Arg Tyr Met Val His Leu Ser Phe Glu Glu 
            260                 265                 270         


Ile Thr Lys Ile Ser Pro Ile Glu Ile Gly Leu Phe Ile Ser Tyr Asp 
        275                 280                 285             


Asn Ala Thr Lys Gln Leu Asp Met Val Tyr Asp Ile Thr Pro Glu Leu 
    290                 295                 300                 


Ala Gln Ala Phe Leu Glu Arg Ile Ser Ser Ser Asn Phe Asn Met Arg 
305                 310                 315                 320 


Asn Thr Ser Thr Ile His Arg Leu Gly Leu Leu Val Cys Phe Tyr Asn 
                325                 330                 335     


Asp Leu Glu Leu Leu Asp Ala Thr Val Ala Gln Val Leu Leu Tyr Gln 
            340                 345                 350         


Met Ile Lys Cys Ser His Leu Arg Gly Phe Gln Ala Gly Val Gln Lys 
        355                 360                 365             


Leu Lys Ala Glu Leu Leu Asp Ile Ala Met Glu Asn Gln Thr Leu Asn 
    370                 375                 380                 


Glu Thr Leu Gly Ser Leu Ser Asp Ala Val Val Gly Leu Thr Tyr Ser 
385                 390                 395                 400 


Gln Leu Glu Ser Leu Ser Pro Glu Ala Val His Gly Ala Ile Ser Thr 
                405                 410                 415     


Leu Asn Gln Val Ser Gly Trp Ala Lys Ser Gln Val Ile Ile Leu Ser 
            420                 425                 430         


Ala Lys Tyr Leu Ala His Glu Lys Val Leu Ser Phe Tyr Asn Val Ser 
        435                 440                 445             


Gln Met Gly Ala Leu Leu Ala Gly Val Ser Thr Gln Ala Phe Cys Ser 
    450                 455                 460                 


Met Lys Arg Lys Asp Ile Ser Gln Val Leu Arg Ser Ala Val Ser Gln 
465                 470                 475                 480 


Tyr Val Ser Asp Leu Ser Pro Ala Gln Gln Gln Gly Ile Leu Ser Lys 
                485                 490                 495     


Met Val Gln Ala Glu Asp Thr Ala Pro Gly Ile Val Glu Ile Gln Gly 
            500                 505                 510         


Ala Phe Phe Lys Glu Val Ser Leu Phe Asp Leu Arg Arg Gln Pro Gly 
        515                 520                 525             


Phe Asn Ser Thr Val Leu Lys Asp Lys Glu Leu Gly Arg Ser Gln Ala 
    530                 535                 540                 


Leu Phe Leu Tyr Glu Leu Leu Leu Lys Thr Thr Arg Arg Pro Glu Glu 
545                 550                 555                 560 


Leu Leu Ser Ala Gly Gln Leu Val Lys Gly Val Thr Cys Ser His Ile 
                565                 570                 575     


Asp Ala Met Ser Thr Asp Phe Phe Leu Ala His Phe Gln Asp Phe Gln 
            580                 585                 590         


Asn Asn Phe Ala Leu Leu Ser Pro Tyr Gln Val Asn Cys Leu Ala Trp 
        595                 600                 605             


Lys Tyr Trp Glu Val Ser Arg Leu Ser Met Pro Pro Phe Leu Leu Ala 
    610                 615                 620                 


Ala Leu Pro Ala Arg Tyr Leu Ala Ser Val Pro Ala Ser Gln Cys Val 
625                 630                 635                 640 


Pro Phe Leu Ile Ser Leu Gly Lys Ser Trp Leu Asp Ser Leu Val Leu 
                645                 650                 655     


Asp Ser His Lys Lys Thr Ser Val Leu Arg Lys Val Gln Gln Cys Leu 
            660                 665                 670         


Asp Asp Ser Ile Ala Asp Glu Tyr Thr Val Asp Ile Met Gly Asn Leu 
        675                 680                 685             


Leu Cys His Leu Pro Ala Ala Ile Ile Asp Arg Gly Ile Ser Pro Arg 
    690                 695                 700                 


Ala Trp Ala Thr Ala Leu His Gly Leu Arg Asp Cys Pro Asp Leu Asn 
705                 710                 715                 720 


Pro Glu Gln Lys Ala Ala Val Arg Leu Lys Leu Leu Gly Gln Tyr Gly 
                725                 730                 735     


Leu Pro Gln His Trp Thr Ala Glu Thr Thr Lys Asp Leu Gly Pro Phe 
            740                 745                 750         


Leu Val Leu Phe Ser Gly Asp Glu Leu Ser Ser Ile Ala Thr Lys Phe 
        755                 760                 765             


Pro Glu Ile Leu Leu Gln Ala Ala Ser Lys Met Ala Arg Thr Leu Pro 
    770                 775                 780                 


Thr Lys Glu Phe Leu Trp Ala Val Phe Gln Ser Val Arg Asn Ser Ser 
785                 790                 795                 800 


Asp Lys Ile Pro Ser Tyr Asp Pro Met Pro Gly Cys His Gly Val Val 
                805                 810                 815     


Ala Pro Ser Ser Asp Asp Ile Phe Lys Leu Ala Glu Ala Asn Ala Cys 
            820                 825                 830         


Trp Ala Leu Glu Asp Leu Arg Cys Met Glu Glu Asp Thr Phe Ile Arg 
        835                 840                 845             


Thr Val Glu Leu Leu Gly Ala Val Gln Gly Phe Ser Arg Pro Gln Leu 
    850                 855                 860                 


Met Thr Leu Lys Glu Lys Ala Ile Gln Val Trp Asp Met Pro Ser Tyr 
865                 870                 875                 880 


Trp Arg Glu His His Ile Val Ser Leu Gly Arg Ile Ala Leu Ala Leu 
                885                 890                 895     


Asn Glu Ser Glu Leu Glu Gln Leu Asp Leu Ser Ser Ile Asp Thr Val 
            900                 905                 910         


Ala Ser Leu Ser Trp Gln Thr Glu Trp Thr Pro Gly Gln Ala Glu Ser 
        915                 920                 925             


Ile Leu Gln Gly Tyr Leu Asp Asp Ser Gly Tyr Ser Ile Gln Asp Leu 
    930                 935                 940                 


Lys Ser Phe His Leu Val Gly Leu Gly Ala Thr Leu Cys Ala Ile Asn 
945                 950                 955                 960 


Ile Thr Glu Ile Pro Leu Ile Lys Ile Ser Glu Phe Arg Val Val Val 
                965                 970                 975     


Ala Arg Ile Gly Thr Leu Leu Cys Ser Thr His Val Leu Ala Glu Phe 
            980                 985                 990         


Lys Arg Lys Ala Glu Val Val Phe  Gly Asp Pro Thr Glu  Trp Thr Ser 
        995                 1000                 1005             


Ser Val  Leu Gln Glu Leu Gly  Thr Ile Ala Ala Gly  Leu Thr Lys 
    1010                 1015                 1020             


Ala Glu  Leu Arg Met Leu Asp  Lys Asp Leu Met Pro  Tyr Phe Gln 
    1025                 1030                 1035             


Pro Ser  Ala Ile Lys Cys Leu  Pro Asp Glu Ile Phe  Lys Glu Leu 
    1040                 1045                 1050             


Ser Ala  Glu Gln Ile Ala Ser  Leu Gly Pro Glu Asn  Ala Ala Ala 
    1055                 1060                 1065             


Val Thr  His Ala Gln Arg Arg  Arg Leu Ser Pro Leu  Gln Leu Gln 
    1070                 1075                 1080             


Ser Leu  Gln Gln Ala Leu Asp  Gly Ala Lys Thr His  Ser Trp Gln 
    1085                 1090                 1095             


Asp Ala  Pro Ala Ser Ala Gly  Pro Thr Arg Thr Ser  Ser Ser Arg 
    1100                 1105                 1110             


Ser Pro  Ala Gly Ala Leu Gln  Ser Trp Gly Leu Trp  Leu Gly Cys 
    1115                 1120                 1125             


Pro Leu  Leu Val Leu Met Ala  Lys Leu Leu Trp 
    1130                 1135                 


<210>  9867
<211>  1139
<212>  PRT
<213>  Homo Sapiens

<400>  9867

Met Ser Gln Glu Pro Thr Thr Tyr Ser Leu Phe Leu Phe Leu Phe Leu 
1               5                   10                  15      


Ser His Gly Val Ser Ser Tyr Thr Val Pro Asn Ser Arg Gln Asp Leu 
            20                  25                  30          


His Pro Leu Leu Gln Asn Met Ala Glu Glu Ile Ile Asp Gly Ser Tyr 
        35                  40                  45              


Leu Asn Ala Leu Leu Asp Leu Ile Gln Phe Gln Ser Ser His Val Trp 
    50                  55                  60                  


Thr Asp Asp Leu Ser His Arg Val Leu Ala Tyr Leu Asn Ser Arg Asn 
65                  70                  75                  80  


Val Ala Phe Thr Ile Pro Ser Leu Gln Ala Ala Val Glu Asn His Leu 
                85                  90                  95      


Glu Gln Arg Leu His Gln Pro Gln Lys Leu Leu Glu Asp Leu Arg Lys 
            100                 105                 110         


Thr Asp Ala Gln Gln Phe Arg Thr Ala Met Lys Cys Leu Leu Glu Asp 
        115                 120                 125             


Lys Lys Asp Gly Leu Asp Leu Lys Asp Ile Ile Ile Asp Leu Gly Glu 
    130                 135                 140                 


Ile Arg Glu Arg Ala Leu Gln Ser Pro Gly Val Asn Arg Ser Leu Phe 
145                 150                 155                 160 


Leu Ile Thr Leu Glu Arg Cys Phe Gln Met Leu Asn Ser Leu Glu Cys 
                165                 170                 175     


Val Glu Ile Leu Gly Lys Val Leu Arg Gly Ser Ser Gly Ser Phe Leu 
            180                 185                 190         


Gln Pro Asp Ile Thr Glu Arg Leu Pro Arg Asp Leu Arg Glu Asp Ala 
        195                 200                 205             


Phe Lys Asn Leu Ser Ala Val Phe Lys Asp Leu Tyr Asp Lys Thr Ser 
    210                 215                 220                 


Ala His Ser Gln Arg Ala Leu Tyr Ser Trp Met Thr Gly Ile Leu Gln 
225                 230                 235                 240 


Thr Ser Ser Asn Ala Thr Asp Asp Ser Ala Ser Trp Val Ser Ala Glu 
                245                 250                 255     


His Leu Trp Val Leu Gly Arg Tyr Met Val His Leu Ser Phe Glu Glu 
            260                 265                 270         


Ile Thr Lys Ile Ser Pro Ile Glu Ile Gly Leu Phe Ile Ser Tyr Asp 
        275                 280                 285             


Asn Ala Thr Lys Gln Leu Asp Met Val Tyr Asp Ile Thr Pro Glu Leu 
    290                 295                 300                 


Ala Gln Ala Phe Leu Glu Arg Ile Ser Ser Ser Asn Phe Asn Met Arg 
305                 310                 315                 320 


Asn Thr Ser Thr Ile His Arg Leu Gly Leu Leu Val Cys Phe Tyr Asn 
                325                 330                 335     


Asp Leu Glu Leu Leu Asp Ala Thr Val Ala Gln Val Leu Leu Tyr Gln 
            340                 345                 350         


Met Ile Lys Cys Ser His Leu Arg Gly Phe Gln Ala Gly Val Gln Lys 
        355                 360                 365             


Leu Lys Ala Glu Leu Leu Asp Ile Ala Met Glu Asn Gln Thr Leu Asn 
    370                 375                 380                 


Glu Thr Leu Gly Ser Leu Ser Asp Ala Val Val Gly Leu Thr Tyr Ser 
385                 390                 395                 400 


Gln Leu Glu Ser Leu Ser Pro Glu Ala Val His Gly Ala Ile Ser Thr 
                405                 410                 415     


Leu Asn Gln Val Ser Gly Trp Ala Lys Ser Gln Val Ile Ile Leu Ser 
            420                 425                 430         


Ala Lys Tyr Leu Ala His Glu Lys Val Leu Ser Phe Tyr Asn Val Ser 
        435                 440                 445             


Gln Met Gly Ala Leu Leu Ala Gly Val Ser Thr Gln Ala Phe Cys Ser 
    450                 455                 460                 


Met Lys Arg Lys Asp Ile Ser Gln Val Leu Arg Ser Ala Val Ser Gln 
465                 470                 475                 480 


Tyr Val Ser Asp Leu Ser Pro Ala Gln Gln Gln Gly Ile Leu Ser Lys 
                485                 490                 495     


Met Val Gln Ala Glu Asp Thr Ala Pro Gly Ile Val Glu Ile Gln Gly 
            500                 505                 510         


Ala Phe Phe Lys Glu Val Ser Leu Phe Asp Leu Arg Arg Gln Pro Gly 
        515                 520                 525             


Phe Asn Ser Thr Val Leu Lys Asp Lys Glu Leu Gly Arg Ser Gln Ala 
    530                 535                 540                 


Leu Phe Leu Tyr Glu Leu Leu Leu Lys Thr Thr Arg Arg Pro Glu Glu 
545                 550                 555                 560 


Leu Leu Ser Ala Gly Gln Leu Val Lys Gly Val Thr Cys Ser His Ile 
                565                 570                 575     


Asp Ala Met Ser Thr Asp Phe Phe Leu Ala His Phe Gln Asp Phe Gln 
            580                 585                 590         


Asn Asn Phe Ala Leu Leu Ser Pro Tyr Gln Val Asn Cys Leu Ala Trp 
        595                 600                 605             


Lys Tyr Trp Glu Val Ser Arg Leu Ser Met Pro Pro Phe Leu Leu Ala 
    610                 615                 620                 


Ala Leu Pro Ala Arg Tyr Leu Ala Ser Val Pro Ala Ser Gln Cys Val 
625                 630                 635                 640 


Pro Phe Leu Ile Ser Leu Gly Lys Ser Trp Leu Asp Ser Leu Val Leu 
                645                 650                 655     


Asp Ser His Lys Lys Thr Ser Val Leu Arg Lys Val Gln Gln Cys Leu 
            660                 665                 670         


Asp Asp Ser Ile Ala Asp Glu Tyr Thr Val Asp Ile Met Gly Asn Leu 
        675                 680                 685             


Leu Cys His Leu Pro Ala Ala Ile Ile Asp Arg Gly Ile Ser Pro Arg 
    690                 695                 700                 


Ala Trp Ala Thr Ala Leu His Gly Leu Arg Asp Cys Pro Asp Leu Asn 
705                 710                 715                 720 


Pro Glu Gln Lys Ala Ala Val Arg Leu Lys Leu Leu Gly Gln Tyr Gly 
                725                 730                 735     


Leu Pro Gln His Trp Thr Ala Glu Thr Thr Lys Asp Leu Gly Pro Phe 
            740                 745                 750         


Leu Val Leu Phe Ser Gly Asp Glu Leu Ser Ser Ile Ala Thr Lys Phe 
        755                 760                 765             


Pro Glu Ile Leu Leu Gln Ala Ala Ser Lys Met Ala Arg Thr Leu Pro 
    770                 775                 780                 


Thr Lys Glu Phe Leu Trp Ala Val Phe Gln Ser Val Arg Asn Ser Ser 
785                 790                 795                 800 


Asp Lys Ile Pro Ser Tyr Asp Pro Met Pro Gly Cys His Gly Val Val 
                805                 810                 815     


Ala Pro Ser Ser Asp Asp Ile Phe Lys Leu Ala Glu Ala Asn Ala Cys 
            820                 825                 830         


Trp Ala Leu Glu Asp Leu Arg Cys Met Glu Glu Asp Thr Phe Ile Arg 
        835                 840                 845             


Thr Val Glu Leu Leu Gly Ala Val Gln Gly Phe Ser Arg Pro Gln Leu 
    850                 855                 860                 


Met Thr Leu Lys Glu Lys Ala Ile Gln Val Trp Asp Met Pro Ser Tyr 
865                 870                 875                 880 


Trp Arg Glu His His Ile Val Ser Leu Gly Arg Ile Ala Leu Ala Leu 
                885                 890                 895     


Asn Glu Ser Glu Leu Glu Gln Leu Asp Leu Ser Ser Ile Asp Thr Val 
            900                 905                 910         


Ala Ser Leu Ser Trp Gln Thr Glu Trp Thr Pro Gly Gln Ala Glu Ser 
        915                 920                 925             


Ile Leu Gln Gly Tyr Leu Asp Asp Ser Gly Tyr Ser Ile Gln Asp Leu 
    930                 935                 940                 


Lys Ser Phe His Leu Val Gly Leu Gly Ala Thr Leu Cys Ala Ile Asn 
945                 950                 955                 960 


Ile Thr Glu Ile Pro Leu Ile Lys Ile Ser Glu Phe Arg Val Val Val 
                965                 970                 975     


Ala Arg Ile Gly Thr Leu Leu Cys Ser Thr His Val Leu Ala Glu Phe 
            980                 985                 990         


Lys Arg Lys Ala Glu Val Val Phe  Gly Asp Pro Thr Glu  Trp Thr Ser 
        995                 1000                 1005             


Ser Val  Leu Gln Glu Leu Gly  Thr Ile Ala Ala Gly  Leu Thr Lys 
    1010                 1015                 1020             


Ala Glu  Leu Arg Met Leu Asp  Lys Asp Leu Met Pro  Tyr Phe Gln 
    1025                 1030                 1035             


Pro Ser  Ala Ile Lys Cys Leu  Pro Asp Glu Ile Phe  Lys Glu Leu 
    1040                 1045                 1050             


Ser Ala  Glu Gln Ile Ala Ser  Leu Gly Pro Glu Asn  Ala Ala Ala 
    1055                 1060                 1065             


Val Thr  His Ala Gln Arg Arg  Arg Leu Ser Pro Leu  Gln Leu Gln 
    1070                 1075                 1080             


Ser Leu  Gln Gln Ala Leu Asp  Gly Ala Lys Thr His  Ser Trp Gln 
    1085                 1090                 1095             


Asp Ala  Pro Ala Ser Ala Gly  Pro Thr Arg Thr Ser  Ser Ser Arg 
    1100                 1105                 1110             


Ser Pro  Ala Gly Ala Leu Gln  Ser Trp Gly Leu Trp  Leu Gly Cys 
    1115                 1120                 1125             


Pro Leu  Leu Val Leu Met Ala  Lys Leu Leu Trp 
    1130                 1135                 


<210>  9868
<211>  353
<212>  PRT
<213>  Homo Sapiens

<400>  9868

Met Ser Gln Glu Pro Thr Thr Tyr Ser Leu Phe Leu Phe Leu Phe Leu 
1               5                   10                  15      


Ser His Gly Val Ser Ser Tyr Thr Val Pro Asn Ser Arg Gln Asp Leu 
            20                  25                  30          


His Pro Leu Leu Gln Asn Met Ala Glu Glu Ile Ile Asp Gly Ser Tyr 
        35                  40                  45              


Leu Asn Ala Leu Leu Asp Leu Ile Gln Phe Gln Ser Ser His Val Trp 
    50                  55                  60                  


Thr Asp Asp Leu Ser His Arg Val Leu Ala Tyr Leu Asn Ser Arg Asn 
65                  70                  75                  80  


Val Ala Phe Thr Ile Pro Ser Leu Gln Ala Ala Val Glu Asn His Leu 
                85                  90                  95      


Glu Gln Arg Leu His Gln Pro Gln Lys Leu Leu Glu Asp Leu Arg Lys 
            100                 105                 110         


Thr Asp Ala Gln Gln Phe Arg Thr Ala Met Lys Cys Leu Leu Glu Asp 
        115                 120                 125             


Lys Lys Asp Gly Leu Asp Leu Lys Asp Ile Ile Ile Asp Leu Gly Glu 
    130                 135                 140                 


Ile Arg Glu Arg Ala Leu Gln Ser Pro Gly Val Asn Arg Ser Leu Phe 
145                 150                 155                 160 


Leu Ile Thr Leu Glu Arg Cys Phe Gln Met Leu Asn Ser Leu Glu Cys 
                165                 170                 175     


Val Glu Ile Leu Gly Lys Val Leu Arg Gly Ser Ser Gly Ser Phe Leu 
            180                 185                 190         


Gln Pro Asp Ile Thr Glu Arg Leu Pro Arg Asp Leu Arg Glu Asp Ala 
        195                 200                 205             


Phe Lys Asn Leu Ser Ala Val Phe Lys Asp Leu Tyr Asp Lys Thr Ser 
    210                 215                 220                 


Ala His Ser Gln Arg Ala Leu Tyr Ser Trp Met Thr Gly Ile Leu Gln 
225                 230                 235                 240 


Thr Ser Ser Asn Ala Thr Asp Asp Ser Ala Ser Trp Val Ser Ala Glu 
                245                 250                 255     


His Leu Trp Val Leu Gly Arg Tyr Met Val His Leu Ser Phe Glu Glu 
            260                 265                 270         


Ile Thr Lys Ile Ser Pro Ile Glu Ile Gly Leu Phe Ile Ser Tyr Asp 
        275                 280                 285             


Asn Ala Thr Lys Gln Leu Asp Met Val Tyr Asp Ile Thr Pro Glu Leu 
    290                 295                 300                 


Ala Gln Ala Phe Leu Glu Arg Ile Ser Ser Ser Asn Phe Asn Met Arg 
305                 310                 315                 320 


Asn Thr Ser Thr Ile His Ser Ser Lys Gln Asn Ser Trp Thr Leu Pro 
                325                 330                 335     


Trp Arg Thr Arg Pro Ser Met Arg Pro Trp Val Leu Cys Arg Met Gln 
            340                 345                 350         


Leu 
    


<210>  9869
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  9869

Ala Met Gly Asp Lys Ala Thr Val Val Gly Gly Gln Ala Glu Ala Pro 
1               5                   10                  15      


Asp Ser Val Ala Met Ser Ser Trp Glu Arg Arg Leu His Arg Ala Lys 
            20                  25                  30          


Cys Ala Pro Ser Tyr Leu Phe Ser Cys Phe Asn Gly Gly Glu Cys Val 
        35                  40                  45              


His Pro Ala Phe Cys Asp Cys Arg Arg Phe Asn Ala Thr Gly Pro Arg 
    50                  55                  60                  


Cys Gln Met Val Tyr Asn Ala Gly Pro Glu Arg Asp Ser Ile Cys Arg 
65                  70                  75                  80  


Ala Trp Gly Gln His His Val Glu Thr Phe Asp Gly Leu Tyr 
                85                  90                  


<210>  9870
<211>  2913
<212>  PRT
<213>  Homo Sapiens

<400>  9870

Met Gly Val Leu Ala Ser Ala Leu Cys Trp Leu Leu Cys Val Trp Leu 
1               5                   10                  15      


Pro Trp Gly Glu Gln Ala Ala Glu Ser Leu Arg Val Gln Arg Leu Ala 
            20                  25                  30          


Ala Ala Pro Val Leu Trp Gly Ser Ala Glu Pro Gln Pro Glu Pro Ala 
        35                  40                  45              


Gly Gln Pro Ser Ser Ser His Gln Glu Ala Thr Leu Ala Met Gly Asp 
    50                  55                  60                  


Lys Ala Thr Val Val Gly Gly Gln Gln Ala Glu Ala Pro Asp Ser Val 
65                  70                  75                  80  


Ala Met Ser Ser Trp Glu Arg Arg Leu His Arg Ala Lys Cys Ala Pro 
                85                  90                  95      


Ser Tyr Leu Phe Ser Cys Phe Asn Gly Gly Glu Cys Val His Pro Ala 
            100                 105                 110         


Phe Cys Asp Cys Arg Arg Phe Asn Ala Thr Gly Pro Arg Cys Gln Met 
        115                 120                 125             


Val Tyr Asn Ala Gly Pro Glu Arg Asp Ser Ile Cys Arg Ala Trp Gly 
    130                 135                 140                 


Gln His His Val Glu Thr Phe Asp Gly Leu Tyr Tyr Tyr Leu Ser Gly 
145                 150                 155                 160 


Lys Gly Ser Tyr Thr Leu Val Gly Arg His Glu Pro Glu Gly Gln Ser 
                165                 170                 175     


Phe Ser Ile Gln Val His Asn Asp Pro Gln Cys Gly Ser Ser Pro Tyr 
            180                 185                 190         


Thr Cys Ser Arg Ala Val Ser Leu Phe Phe Val Gly Glu Gln Glu Ile 
        195                 200                 205             


His Leu Ala Lys Glu Val Thr His Gly Gly Met Arg Val Gln Leu Pro 
    210                 215                 220                 


His Val Met Gly Ser Ala Arg Leu Gln Gln Leu Ala Gly Tyr Val Ile 
225                 230                 235                 240 


Val Arg His Gln Ser Ala Phe Thr Leu Ala Trp Asp Gly Ala Ser Ala 
                245                 250                 255     


Val Tyr Ile Lys Met Ser Pro Glu Leu Leu Gly Trp Thr His Gly Leu 
            260                 265                 270         


Cys Gly Asn Asn Asn Ala Asp Pro Lys Asp Asp Leu Val Thr Ser Ser 
        275                 280                 285             


Gly Lys Leu Thr Asp Asp Val Val Glu Phe Val His Ser Trp Gln Glu 
    290                 295                 300                 


Gln Ala Pro Asn Gln Pro Pro Gly Pro Thr Thr Ser Ser Leu Pro Arg 
305                 310                 315                 320 


Pro Pro Cys Leu Gln Gln Asn Pro Gly Thr Met Gln Gly Val Tyr Glu 
                325                 330                 335     


Gln Cys Glu Ala Leu Leu Arg Pro Pro Phe Asp Ala Cys His Ala Tyr 
            340                 345                 350         


Val Ser Pro Leu Pro Phe Thr Ala Ser Cys Thr Ser Asp Leu Cys Gln 
        355                 360                 365             


Ser Met Gly Asp Val Ala Thr Trp Cys Arg Ala Leu Ala Glu Tyr Ala 
    370                 375                 380                 


Arg Ala Cys Ala Gln Ala Gly Arg Pro Leu Gln Gly Trp Arg Thr Gln 
385                 390                 395                 400 


Leu Arg Gln Cys Thr Val His Cys Lys Glu Lys Ala Phe Thr Tyr Asn 
                405                 410                 415     


Glu Cys Ile Ala Cys Cys Pro Ala Ser Cys His Pro Arg Ala Ser Cys 
            420                 425                 430         


Val Asp Ser Glu Ile Ala Cys Val Asp Gly Cys Tyr Cys Pro Asn Gly 
        435                 440                 445             


Leu Ile Phe Glu Asp Gly Gly Cys Val Ala Pro Ala Glu Cys Pro Cys 
    450                 455                 460                 


Glu Phe His Gly Thr Leu Tyr Pro Pro Gly Ser Val Val Lys Glu Asp 
465                 470                 475                 480 


Cys Asn Thr Cys Thr Cys Thr Ser Gly Lys Trp Glu Cys Ser Thr Ala 
                485                 490                 495     


Val Cys Pro Ala Glu Cys Ser Val Thr Gly Asp Ile His Phe Thr Thr 
            500                 505                 510         


Phe Asp Gly Arg Arg Tyr Thr Phe Pro Ala Thr Cys Gln Tyr Ile Leu 
        515                 520                 525             


Ala Lys Ser Arg Ser Ser Gly Thr Phe Thr Val Thr Leu Gln Asn Ala 
    530                 535                 540                 


Pro Cys Gly Leu Asn Gln Asp Gly Ala Cys Val Gln Ser Val Ser Val 
545                 550                 555                 560 


Ile Leu His Gln Asp Pro Arg Arg Gln Val Thr Leu Thr Gln Ala Gly 
                565                 570                 575     


Asp Val Leu Leu Phe Asp Gln Tyr Lys Ile Ile Pro Pro Tyr Thr Asp 
            580                 585                 590         


Asp Ala Phe Glu Ile Arg Arg Leu Ser Ser Val Phe Leu Arg Val Arg 
        595                 600                 605             


Thr Asn Val Gly Val Arg Val Leu Tyr Asp Arg Glu Gly Leu Arg Leu 
    610                 615                 620                 


Tyr Leu Gln Val Asp Gln Arg Trp Val Glu Asp Thr Val Gly Leu Cys 
625                 630                 635                 640 


Gly Thr Phe Asn Gly Asn Thr Gln Asp Asp Phe Leu Ser Pro Val Gly 
                645                 650                 655     


Val Pro Glu Ser Thr Pro Gln Leu Phe Gly Asn Ser Trp Lys Thr Leu 
            660                 665                 670         


Ser Ala Cys Ser Pro Leu Val Ser Gly Ser Pro Leu Asp Pro Cys Asp 
        675                 680                 685             


Val His Leu Gln Ala Ala Ser Tyr Ser Val Gln Ala Cys Ser Val Leu 
    690                 695                 700                 


Thr Gly Glu Met Phe Ala Pro Cys Ser Ala Phe Leu Ser Pro Val Pro 
705                 710                 715                 720 


Tyr Phe Glu Gln Cys Arg Arg Asp Ala Cys Arg Cys Gly Gln Pro Cys 
                725                 730                 735     


Leu Cys Ala Thr Leu Ala His Tyr Ala His Leu Cys Arg Arg His Gly 
            740                 745                 750         


Leu Pro Val Asp Phe Arg Ala Arg Leu Pro Ala Cys Ala Leu Ser Cys 
        755                 760                 765             


Glu Ala Ser Lys Glu Tyr Ser Pro Cys Val Ala Pro Cys Gly Arg Thr 
    770                 775                 780                 


Cys Gln Asp Leu Ala Ser Pro Glu Ala Cys Gly Val Asp Gly Gly Asp 
785                 790                 795                 800 


Asp Leu Ser Arg Asp Glu Cys Val Glu Gly Cys Ala Cys Pro Pro Asp 
                805                 810                 815     


Thr Tyr Leu Asp Thr Gln Ala Asp Leu Cys Val Pro Arg Asn Gln Cys 
            820                 825                 830         


Ser Cys His Phe Gln Gly Val Asp Tyr Pro Pro Gly Asp Ser Asp Ile 
        835                 840                 845             


Pro Ser Leu Gly His Cys His Cys Lys Asp Gly Val Met Ser Cys Asp 
    850                 855                 860                 


Ser Arg Ala Pro Ala Ala Ala Cys Pro Ala Gly Gln Val Phe Val Asn 
865                 870                 875                 880 


Cys Ser Asp Leu His Thr Asp Leu Glu Leu Ser Arg Glu Arg Thr Cys 
                885                 890                 895     


Glu Gln Gln Leu Leu Asn Leu Ser Val Ser Ala Arg Gly Pro Cys Leu 
            900                 905                 910         


Ser Gly Cys Ala Cys Pro Gln Gly Leu Leu Arg His Gly Asp Ala Cys 
        915                 920                 925             


Phe Leu Pro Glu Glu Cys Pro Cys Thr Trp Lys Gly Lys Glu Tyr Phe 
    930                 935                 940                 


Pro Gly Asp Gln Val Met Ser Pro Cys His Thr Cys Val Cys Gln Arg 
945                 950                 955                 960 


Gly Ser Phe Gln Cys Thr Leu His Pro Cys Ala Ser Thr Cys Thr Ala 
                965                 970                 975     


Tyr Gly Asp Arg His Tyr Arg Thr Phe Asp Gly Leu Pro Phe Asp Phe 
            980                 985                 990         


Val Gly Ala Cys Lys Val His Leu  Val Lys Ser Thr Ser  Asp Val Ser 
        995                 1000                 1005             


Phe Ser  Val Ile Val Glu Asn  Val Asn Cys Tyr Ser  Ser Gly Met 
    1010                 1015                 1020             


Ile Cys  Arg Lys Phe Ile Ser  Ile Asn Val Gly Asn  Ser Leu Ile 
    1025                 1030                 1035             


Val Phe  Asp Asp Asp Ser Gly  Asn Pro Ser Pro Glu  Ser Phe Leu 
    1040                 1045                 1050             


Asp Asp  Lys Gln Glu Val His  Thr Trp Arg Val Gly  Phe Phe Thr 
    1055                 1060                 1065             


Leu Val  His Phe Pro Gln Glu  His Ile Thr Leu Leu  Trp Asp Gln 
    1070                 1075                 1080             


Arg Thr  Thr Val His Val Gln  Ala Gly Pro Gln Trp  Gln Gly Gln 
    1085                 1090                 1095             


Leu Ala  Gly Leu Cys Gly Asn  Phe Asp Leu Lys Thr  Ile Asn Glu 
    1100                 1105                 1110             


Met Arg  Thr Pro Glu Asn Leu  Glu Leu Thr Asn Pro  Gln Glu Phe 
    1115                 1120                 1125             


Gly Ser  Ser Trp Ala Ala Val  Glu Cys Pro Asp Thr  Leu Asp Pro 
    1130                 1135                 1140             


Arg Asp  Met Cys Val Leu Asn  Pro Leu Arg Glu Pro  Phe Ala Lys 
    1145                 1150                 1155             


Lys Glu  Cys Ser Ile Leu Leu  Ser Glu Val Phe Glu  Ile Cys His 
    1160                 1165                 1170             


Pro Val  Val Asp Val Thr Trp  Phe Tyr Ser Asn Cys  Leu Thr Asp 
    1175                 1180                 1185             


Thr Cys  Gly Cys Ser Gln Gly  Gly Asp Cys Glu Cys  Phe Cys Ala 
    1190                 1195                 1200             


Ser Val  Ser Ala Tyr Ala His  Gln Cys Cys Gln His  Gly Val Ala 
    1205                 1210                 1215             


Val Asp  Trp Arg Thr Pro Arg  Leu Cys Pro Tyr Asp  Cys Asp Phe 
    1220                 1225                 1230             


Phe Asn  Lys Val Leu Gly Lys  Gly Pro Tyr Gln Leu  Ser Ser Leu 
    1235                 1240                 1245             


Ala Ala  Gly Gly Ala Leu Val  Gly Met Lys Ala Val  Gly Asp Asp 
    1250                 1255                 1260             


Ile Val  Leu Val Arg Thr Glu  Asp Val Ala Pro Ala  Asp Ile Val 
    1265                 1270                 1275             


Ser Phe  Leu Leu Thr Ala Ala  Leu Tyr Lys Ala Lys  Ala His Asp 
    1280                 1285                 1290             


Pro Asp  Val Val Ser Leu Glu  Ala Ala Asp Arg Pro  Asn Phe Phe 
    1295                 1300                 1305             


Leu His  Val Thr Ala Asn Gly  Ser Leu Glu Leu Ala  Lys Trp Gln 
    1310                 1315                 1320             


Gly Arg  Asp Thr Phe Gln Gln  His Ala Ser Phe Leu  Leu His Arg 
    1325                 1330                 1335             


Gly Thr  Arg Gln Ala Gly Leu  Val Ala Leu Glu Ser  Leu Ala Lys 
    1340                 1345                 1350             


Pro Ser  Ser Phe Leu Tyr Val  Ser Gly Ala Val Leu  Ala Leu Arg 
    1355                 1360                 1365             


Leu Tyr  Glu His Thr Glu Val  Phe Arg Arg Gly Thr  Leu Phe Arg 
    1370                 1375                 1380             


Leu Leu  Asp Ala Lys Pro Ser  Gly Ala Ala Tyr Pro  Ile Cys Glu 
    1385                 1390                 1395             


Trp Arg  Tyr Asp Ala Cys Ala  Ser Pro Cys Phe Gln  Thr Cys Arg 
    1400                 1405                 1410             


Asp Pro  Arg Ala Ala Ser Cys  Arg Asp Val Pro Arg  Val Glu Gly 
    1415                 1420                 1425             


Cys Val  Pro Val Cys Pro Thr  Pro Gln Val Leu Asp  Glu Val Thr 
    1430                 1435                 1440             


Gln Arg  Cys Val Tyr Leu Glu  Asp Cys Val Glu Pro  Ala Val Trp 
    1445                 1450                 1455             


Val Pro  Thr Glu Ala Leu Gly  Asn Glu Thr Leu Pro  Pro Ser Gln 
    1460                 1465                 1470             


Gly Leu  Pro Thr Pro Ser Asp  Glu Glu Pro Gln Leu  Ser Gln Glu 
    1475                 1480                 1485             


Ser Pro  Arg Thr Pro Thr His  Arg Pro Ala Leu Thr  Pro Ala Ala 
    1490                 1495                 1500             


Pro Leu  Thr Thr Ala Leu Asn  Pro Pro Val Thr Ala  Thr Glu Glu 
    1505                 1510                 1515             


Pro Val  Val Ser Pro Gly Pro  Thr Gln Thr Thr Leu  Gln Gln Pro 
    1520                 1525                 1530             


Leu Glu  Leu Thr Ala Ser Gln  Leu Pro Ala Gly Pro  Thr Glu Ser 
    1535                 1540                 1545             


Pro Ala  Ser Lys Gly Val Thr  Ala Ser Leu Leu Ala  Ile Pro His 
    1550                 1555                 1560             


Thr Pro  Glu Ser Ser Ser Leu  Pro Val Ala Leu Gln  Thr Pro Thr 
    1565                 1570                 1575             


Pro Gly  Met Val Ser Gly Ala  Met Glu Thr Thr Arg  Val Thr Val 
    1580                 1585                 1590             


Ile Phe  Ala Gly Ser Pro Asn  Ile Thr Val Ser Ser  Arg Ser Pro 
    1595                 1600                 1605             


Pro Ala  Pro Arg Phe Pro Leu  Met Thr Lys Ala Val  Thr Val Arg 
    1610                 1615                 1620             


Gly His  Gly Ser Leu Pro Val  Arg Thr Thr Pro Pro  Gln Pro Ser 
    1625                 1630                 1635             


Leu Thr  Ala Ser Pro Ser Ser  Arg Pro Val Ala Ser  Pro Gly Ala 
    1640                 1645                 1650             


Ile Ser  Arg Ser Pro Thr Ser  Ser Gly Ser His Lys  Ala Val Leu 
    1655                 1660                 1665             


Thr Pro  Ala Val Thr Lys Val  Ile Ser Arg Thr Gly  Val Pro Gln 
    1670                 1675                 1680             


Pro Thr  Gln Ala Gln Ser Ala  Ser Ser Pro Ser Thr  Pro Leu Thr 
    1685                 1690                 1695             


Val Ala  Gly Thr Ala Ala Glu  Gln Val Pro Val Ser  Pro Leu Ala 
    1700                 1705                 1710             


Thr Arg  Ser Leu Glu Ile Val  Leu Ser Thr Glu Lys  Gly Glu Ala 
    1715                 1720                 1725             


Gly His  Ser Gln Pro Met Gly  Ser Pro Ala Ser Pro  Gln Pro His 
    1730                 1735                 1740             


Pro Leu  Pro Ser Ala Pro Pro  Arg Pro Ala Gln His  Thr Thr Met 
    1745                 1750                 1755             


Ala Thr  Arg Ser Pro Ala Leu  Pro Pro Glu Thr Pro  Ala Ala Ala 
    1760                 1765                 1770             


Ser Leu  Ser Thr Ala Thr Asp  Gly Leu Ala Ala Thr  Pro Phe Met 
    1775                 1780                 1785             


Ser Leu  Glu Ser Thr Arg Pro  Ser Gln Leu Leu Ser  Gly Leu Pro 
    1790                 1795                 1800             


Pro Asp  Thr Ser Leu Pro Leu  Ala Lys Val Gly Thr  Ser Ala Pro 
    1805                 1810                 1815             


Val Ala  Thr Pro Gly Pro Lys  Ala Ser Val Ile Thr  Thr Pro Leu 
    1820                 1825                 1830             


Gln Pro  Gln Ala Thr Thr Leu  Pro Ala Gln Thr Leu  Ser Pro Val 
    1835                 1840                 1845             


Leu Pro  Phe Thr Pro Ala Ala  Met Thr Gln Ala His  Pro Pro Thr 
    1850                 1855                 1860             


His Ile  Ala Pro Pro Ala Ala  Gly Thr Ala Pro Gly  Leu Leu Leu 
    1865                 1870                 1875             


Gly Ala  Thr Leu Pro Thr Ser  Gly Val Leu Pro Val  Ala Glu Gly 
    1880                 1885                 1890             


Thr Ala  Ser Met Val Ser Val  Val Pro Arg Lys Ser  Thr Thr Gly 
    1895                 1900                 1905             


Lys Val  Ala Ile Leu Ser Lys  Gln Val Ser Leu Pro  Thr Ser Met 
    1910                 1915                 1920             


Tyr Gly  Ser Ala Glu Gly Gly  Pro Thr Glu Leu Thr  Pro Ala Thr 
    1925                 1930                 1935             


Ser His  Pro Leu Thr Pro Leu  Val Ala Glu Pro Glu  Gly Ala Gln 
    1940                 1945                 1950             


Ala Gly  Thr Ala Leu Pro Val  Pro Thr Ser Tyr Ala  Leu Ser Arg 
    1955                 1960                 1965             


Val Ser  Ala Arg Thr Ala Pro  Gln Asp Ser Met Leu  Val Leu Leu 
    1970                 1975                 1980             


Pro Gln  Leu Ala Glu Ala His  Gly Thr Ser Ala Gly  Pro His Leu 
    1985                 1990                 1995             


Ala Ala  Glu Pro Val Asp Glu  Ala Thr Thr Glu Pro  Ser Gly Arg 
    2000                 2005                 2010             


Ser Ala  Pro Ala Leu Ser Ile  Val Glu Gly Leu Ala  Glu Ala Leu 
    2015                 2020                 2025             


Ala Thr  Thr Thr Glu Ala Asn  Thr Ser Thr Thr Cys  Val Pro Ile 
    2030                 2035                 2040             


Ala Glu  Gln Asp Cys Val Arg  His Ile Cys Leu Glu  Gly Gln Leu 
    2045                 2050                 2055             


Ile Arg  Val Asn Gln Ser Gln  His Cys Pro Gln Gly  Ala Ala Pro 
    2060                 2065                 2070             


Pro Arg  Cys Gly Ile Leu Gly  Leu Ala Val Arg Val  Gly Gly Asp 
    2075                 2080                 2085             


Arg Cys  Cys Pro Leu Trp Glu  Cys Ala Cys Arg Cys  Ser Ile Phe 
    2090                 2095                 2100             


Pro Asp  Leu Ser Phe Val Thr  Phe Asp Gly Ser His  Val Ala Leu 
    2105                 2110                 2115             


Phe Lys  Glu Ala Ile Tyr Ile  Leu Ser Gln Ser Pro  Asp Glu Met 
    2120                 2125                 2130             


Leu Thr  Val His Val Leu Asp  Cys Lys Ser Ala Asn  Leu Gly His 
    2135                 2140                 2145             


Leu Asn  Trp Pro Pro Phe Cys  Leu Val Met Leu Asn  Met Thr His 
    2150                 2155                 2160             


Leu Ala  His Gln Val Thr Ile  Asp Arg Phe Asn Arg  Lys Val Thr 
    2165                 2170                 2175             


Val Asp  Leu Gln Pro Val Trp  Pro Pro Val Ser Arg  Tyr Gly Phe 
    2180                 2185                 2190             


Arg Ile  Glu Asp Thr Gly His  Met Tyr Met Ile Leu  Thr Pro Ser 
    2195                 2200                 2205             


Asp Ile  Gln Ile Gln Trp Leu  His Ser Ser Gly Leu  Met Ile Val 
    2210                 2215                 2220             


Glu Ala  Ser Lys Thr Ser Lys  Ala Gln Gly His Gly  Leu Cys Gly 
    2225                 2230                 2235             


Ile Cys  Asp Gly Asp Ala Ala  Asn Asp Leu Thr Leu  Lys Asp Gly 
    2240                 2245                 2250             


Ser Val  Val Gly Gly Ala Glu  Asp Pro Ala Pro Phe  Leu Asp Ser 
    2255                 2260                 2265             


Trp Gln  Val Pro Ser Ser Leu  Thr Ser Val Gly Gln  Thr Arg Phe 
    2270                 2275                 2280             


Arg Pro  Asp Ser Cys Ala Thr  Thr Asp Cys Ser Pro  Cys Leu Arg 
    2285                 2290                 2295             


Met Val  Ser Asn Arg Thr Phe  Ser Ala Cys His Arg  Phe Val Pro 
    2300                 2305                 2310             


Pro Glu  Ser Phe Cys Glu Leu  Trp Ile Arg Asp Thr  Lys Tyr Val 
    2315                 2320                 2325             


Gln Gln  Pro Cys Val Ala Leu  Thr Val Tyr Val Ala  Met Cys His 
    2330                 2335                 2340             


Lys Phe  His Val Cys Ile Glu  Trp Arg Arg Ser Asp  Tyr Cys Pro 
    2345                 2350                 2355             


Phe Leu  Cys Ser Ser Asp Ser  Thr Tyr Gln Ala Cys  Val Thr Ala 
    2360                 2365                 2370             


Cys Glu  Pro Pro Lys Thr Cys  Gln Asp Gly Ile Leu  Gly Pro Leu 
    2375                 2380                 2385             


Asp Pro  Glu His Cys Gln Val  Leu Gly Glu Gly Cys  Val Cys Ser 
    2390                 2395                 2400             


Glu Gly  Thr Ile Leu His Arg  Arg His Ser Ala Leu  Cys Ile Pro 
    2405                 2410                 2415             


Glu Ala  Lys Cys Ala Cys Thr  Asp Ser Met Gly Val  Pro Arg Ala 
    2420                 2425                 2430             


Leu Gly  Glu Thr Trp Asn Ser  Ser Leu Ser Gly Cys  Cys Gln His 
    2435                 2440                 2445             


Gln Cys  Gln Ala Pro Asp Thr  Ile Val Pro Val Asp  Leu Gly Cys 
    2450                 2455                 2460             


Pro Ser  Pro Arg Pro Glu Ser  Cys Leu Arg Phe Gly  Glu Val Ala 
    2465                 2470                 2475             


Leu Leu  Leu Pro Thr Lys Asp  Pro Cys Cys Leu Gly  Thr Val Cys 
    2480                 2485                 2490             


Val Cys  Asn Gln Thr Leu Cys  Glu Gly Leu Ala Pro  Thr Cys Arg 
    2495                 2500                 2505             


Pro Gly  His Arg Leu Leu Thr  His Phe Gln Glu Asp  Ser Cys Cys 
    2510                 2515                 2520             


Pro Ser  Tyr Ser Cys Glu Cys  Asp Pro Asp Leu Cys  Glu Ala Glu 
    2525                 2530                 2535             


Leu Val  Pro Ser Cys Arg Gln  Asp Gln Ile Leu Ile  Thr Gly Arg 
    2540                 2545                 2550             


Leu Gly  Asp Ser Cys Cys Thr  Ser Tyr Phe Cys Ala  Cys Gly Asp 
    2555                 2560                 2565             


Cys Pro  Asp Ser Ile Pro Glu  Cys Gln Glu Gly Glu  Ala Leu Thr 
    2570                 2575                 2580             


Val His  Arg Asn Thr Thr Glu  Leu Cys Cys Pro Leu  Tyr Gln Cys 
    2585                 2590                 2595             


Val Cys  Glu Asn Phe Arg Cys  Pro Gln Val Gln Cys  Gly Leu Gly 
    2600                 2605                 2610             


Thr Ala  Leu Val Glu Val Trp  Ser Pro Asp Arg Cys  Cys Pro Tyr 
    2615                 2620                 2625             


Lys Ser  Cys Glu Cys Asp Cys  Asp Thr Ile Pro Val  Pro Arg Cys 
    2630                 2635                 2640             


His Leu  Trp Glu Lys Ser Gln  Leu Asp Glu Glu Phe  Met His Ser 
    2645                 2650                 2655             


Val Glu  Asn Val Cys Gly Cys  Ala Lys Tyr Glu Cys  Val Lys Ala 
    2660                 2665                 2670             


Pro Val  Cys Leu Ser Arg Glu  Leu Gly Val Met Gln  Pro Gly Gln 
    2675                 2680                 2685             


Thr Val  Val Glu Leu Ser Ala  Asp Gly Val Cys His  Thr Ser Arg 
    2690                 2695                 2700             


Cys Thr  Thr Val Leu Asp Pro  Leu Thr Asn Phe Tyr  Gln Ile Asn 
    2705                 2710                 2715             


Thr Thr  Ser Val Leu Cys Asp  Ile His Cys Glu Ala  Asn Gln Glu 
    2720                 2725                 2730             


Tyr Glu  His Pro Arg Asp Leu  Ala Ala Cys Cys Gly  Ser Cys Arg 
    2735                 2740                 2745             


Asn Val  Ser Cys Leu Phe Thr  Phe Pro Asn Gly Thr  Thr Ser Leu 
    2750                 2755                 2760             


Phe Leu  Pro Gly Ala Ser Trp  Ile Ala Asp Cys Ala  Arg His His 
    2765                 2770                 2775             


Cys Ser  Ser Thr Pro Leu Gly  Ala Val Leu Val Arg  Ser Pro Ile 
    2780                 2785                 2790             


Ser Cys  Pro Pro Leu Asn Glu  Thr Glu Cys Ala Lys  Val Gly Gly 
    2795                 2800                 2805             


Ser Val  Val Pro Ser Leu Glu  Gly Cys Cys Arg Thr  Cys Lys Glu 
    2810                 2815                 2820             


Asp Gly  Arg Ser Cys Lys Lys  Val Thr Ile Arg Met  Thr Ile Arg 
    2825                 2830                 2835             


Lys Asn  Glu Cys Arg Ser Ser  Thr Pro Val Asn Leu  Val Ser Cys 
    2840                 2845                 2850             


Asp Gly  Arg Cys Pro Ser Ala  Ser Ile Tyr Asn Tyr  Asn Ile Asn 
    2855                 2860                 2865             


Thr Tyr  Ala Arg Phe Cys Lys  Cys Cys Arg Glu Val  Gly Leu Gln 
    2870                 2875                 2880             


Arg Arg  Ser Val Gln Leu Phe  Cys Ala Thr Asn Ala  Thr Trp Val 
    2885                 2890                 2895             


Pro Tyr  Thr Val Gln Glu Pro  Thr Asp Cys Ala Cys  Gln Trp Ser 
    2900                 2905                 2910             


<210>  9871
<211>  2925
<212>  PRT
<213>  Homo Sapiens

<400>  9871

Met Gly Val Leu Ala Ser Ala Leu Cys Trp Leu Leu Cys Val Trp Leu 
1               5                   10                  15      


Pro Trp Gly Glu Gln Ala Ala Glu Ser Leu Arg Val Gln Arg Leu Gly 
            20                  25                  30          


Glu Arg Val Val Asp Ser Gly Arg Ser Gly Ala Arg Gly Met Arg Asn 
        35                  40                  45              


Val Lys Gly Met Arg Asn Gly Pro Ala Gln Thr Arg Val Ser Ser Ser 
    50                  55                  60                  


Ser Ser His Gln Glu Ala Thr Leu Ala Met Gly Asp Lys Ala Thr Val 
65                  70                  75                  80  


Val Gly Gly Gln Gln Ala Glu Ala Pro Asp Ser Val Ala Met Ser Ser 
                85                  90                  95      


Trp Glu Arg Arg Leu His Arg Ala Lys Cys Ala Pro Ser Tyr Leu Phe 
            100                 105                 110         


Ser Cys Phe Asn Gly Gly Glu Cys Val His Pro Ala Phe Cys Asp Cys 
        115                 120                 125             


Arg Arg Phe Asn Ala Thr Gly Pro Arg Cys Gln Met Val Tyr Asn Ala 
    130                 135                 140                 


Gly Pro Glu Arg Asp Ser Ile Cys Arg Ala Trp Gly Gln His His Val 
145                 150                 155                 160 


Glu Thr Phe Asp Gly Leu Tyr Tyr Tyr Leu Ser Gly Lys Gly Ser Tyr 
                165                 170                 175     


Thr Leu Val Gly Arg His Glu Pro Glu Gly Gln Ser Phe Ser Ile Gln 
            180                 185                 190         


Val His Asn Asp Pro Gln Cys Gly Ser Ser Pro Tyr Thr Cys Ser Arg 
        195                 200                 205             


Ala Val Ser Leu Phe Phe Val Gly Glu Gln Glu Ile His Leu Ala Lys 
    210                 215                 220                 


Glu Val Thr His Gly Gly Met Arg Val Gln Leu Pro His Val Met Gly 
225                 230                 235                 240 


Ser Ala Arg Leu Gln Gln Leu Ala Gly Tyr Val Ile Val Arg His Gln 
                245                 250                 255     


Ser Ala Phe Thr Leu Ala Trp Asp Gly Ala Ser Ala Val Tyr Ile Lys 
            260                 265                 270         


Met Ser Pro Glu Leu Leu Gly Trp Thr His Gly Leu Cys Gly Asn Asn 
        275                 280                 285             


Asn Ala Asp Pro Lys Asp Asp Leu Val Thr Ser Ser Gly Lys Leu Thr 
    290                 295                 300                 


Asp Asp Val Val Glu Phe Val His Ser Trp Gln Glu Gln Ala Pro Asn 
305                 310                 315                 320 


Gln Pro Pro Gly Pro Thr Thr Ser Ser Leu Pro Arg Pro Pro Cys Leu 
                325                 330                 335     


Gln Gln Asn Pro Gly Thr Met Gln Gly Val Tyr Glu Gln Cys Glu Ala 
            340                 345                 350         


Leu Leu Arg Pro Pro Phe Asp Ala Cys His Ala Tyr Val Ser Pro Leu 
        355                 360                 365             


Pro Phe Thr Ala Ser Cys Thr Ser Asp Leu Cys Gln Ser Met Gly Asp 
    370                 375                 380                 


Val Ala Thr Trp Cys Arg Ala Leu Ala Glu Tyr Ala Arg Ala Cys Ala 
385                 390                 395                 400 


Gln Ala Gly Arg Pro Leu Gln Gly Trp Arg Thr Gln Leu Arg Gln Cys 
                405                 410                 415     


Thr Val His Cys Lys Glu Lys Ala Phe Thr Tyr Asn Glu Cys Ile Ala 
            420                 425                 430         


Cys Cys Pro Ala Ser Cys His Pro Arg Ala Ser Cys Val Asp Ser Glu 
        435                 440                 445             


Ile Ala Cys Val Asp Gly Cys Tyr Cys Pro Asn Gly Leu Ile Phe Glu 
    450                 455                 460                 


Asp Gly Gly Cys Val Ala Pro Ala Glu Cys Pro Cys Glu Phe His Gly 
465                 470                 475                 480 


Thr Leu Tyr Pro Pro Gly Ser Val Val Lys Glu Asp Cys Asn Thr Cys 
                485                 490                 495     


Thr Cys Thr Ser Gly Lys Trp Glu Cys Ser Thr Ala Val Cys Pro Ala 
            500                 505                 510         


Glu Cys Ser Val Thr Gly Asp Ile His Phe Thr Thr Phe Asp Gly Arg 
        515                 520                 525             


Arg Tyr Thr Phe Pro Ala Thr Cys Gln Tyr Ile Leu Ala Lys Ser Arg 
    530                 535                 540                 


Ser Ser Gly Thr Phe Thr Val Thr Leu Gln Asn Ala Pro Cys Gly Leu 
545                 550                 555                 560 


Asn Gln Asp Gly Ala Cys Val Gln Ser Val Ser Val Ile Leu His Gln 
                565                 570                 575     


Asp Pro Arg Arg Gln Val Thr Leu Thr Gln Ala Gly Asp Val Leu Leu 
            580                 585                 590         


Phe Asp Gln Tyr Lys Ile Ile Pro Pro Tyr Thr Asp Asp Ala Phe Glu 
        595                 600                 605             


Ile Arg Arg Leu Ser Ser Val Phe Leu Arg Val Arg Thr Asn Val Gly 
    610                 615                 620                 


Val Arg Val Leu Tyr Asp Arg Glu Gly Leu Arg Leu Tyr Leu Gln Val 
625                 630                 635                 640 


Asp Gln Arg Trp Val Glu Asp Thr Val Gly Leu Cys Gly Thr Phe Asn 
                645                 650                 655     


Gly Asn Thr Gln Asp Asp Phe Leu Ser Pro Val Gly Val Pro Glu Ser 
            660                 665                 670         


Thr Pro Gln Leu Phe Gly Asn Ser Trp Lys Thr Leu Ser Ala Cys Ser 
        675                 680                 685             


Pro Leu Val Ser Gly Ser Pro Leu Asp Pro Cys Asp Val His Leu Gln 
    690                 695                 700                 


Ala Ala Ser Tyr Ser Val Gln Ala Cys Ser Val Leu Thr Gly Glu Met 
705                 710                 715                 720 


Phe Ala Pro Cys Ser Ala Phe Leu Ser Pro Val Pro Tyr Phe Glu Gln 
                725                 730                 735     


Cys Arg Arg Asp Ala Cys Arg Cys Gly Gln Pro Cys Leu Cys Ala Thr 
            740                 745                 750         


Leu Ala His Tyr Ala His Leu Cys Arg Arg His Gly Leu Pro Val Asp 
        755                 760                 765             


Phe Arg Ala Arg Leu Pro Ala Cys Ala Leu Ser Cys Glu Ala Ser Lys 
    770                 775                 780                 


Glu Tyr Ser Pro Cys Val Ala Pro Cys Gly Arg Thr Cys Gln Asp Leu 
785                 790                 795                 800 


Ala Ser Pro Glu Ala Cys Gly Val Asp Gly Gly Asp Asp Leu Ser Arg 
                805                 810                 815     


Asp Glu Cys Val Glu Gly Cys Ala Cys Pro Pro Asp Thr Tyr Leu Asp 
            820                 825                 830         


Thr Gln Ala Asp Leu Cys Val Pro Arg Asn Gln Cys Ser Cys His Phe 
        835                 840                 845             


Gln Gly Val Asp Tyr Pro Pro Gly Asp Ser Asp Ile Pro Ser Leu Gly 
    850                 855                 860                 


His Cys His Cys Lys Asp Gly Val Met Ser Cys Asp Ser Arg Ala Pro 
865                 870                 875                 880 


Ala Ala Ala Cys Pro Ala Gly Gln Val Phe Val Asn Cys Ser Asp Leu 
                885                 890                 895     


His Thr Asp Leu Glu Leu Ser Arg Glu Arg Thr Cys Glu Gln Gln Leu 
            900                 905                 910         


Leu Asn Leu Ser Val Ser Ala Arg Gly Pro Cys Leu Ser Gly Cys Ala 
        915                 920                 925             


Cys Pro Gln Gly Leu Leu Arg His Gly Asp Ala Cys Phe Leu Pro Glu 
    930                 935                 940                 


Glu Cys Pro Cys Thr Trp Lys Gly Lys Glu Tyr Phe Pro Gly Asp Gln 
945                 950                 955                 960 


Val Met Ser Pro Cys His Thr Cys Val Cys Gln Arg Gly Ser Phe Gln 
                965                 970                 975     


Cys Thr Leu His Pro Cys Ala Ser Thr Cys Thr Ala Tyr Gly Asp Arg 
            980                 985                 990         


His Tyr Arg Thr Phe Asp Gly Leu  Pro Phe Asp Phe Val  Gly Ala Cys 
        995                 1000                 1005             


Lys Val  His Leu Val Lys Ser  Thr Ser Asp Val Ser  Phe Ser Val 
    1010                 1015                 1020             


Ile Val  Glu Asn Val Asn Cys  Tyr Ser Ser Gly Met  Ile Cys Arg 
    1025                 1030                 1035             


Lys Phe  Ile Ser Ile Asn Val  Gly Asn Ser Leu Ile  Val Phe Asp 
    1040                 1045                 1050             


Asp Asp  Ser Gly Asn Pro Ser  Pro Glu Ser Phe Leu  Asp Asp Lys 
    1055                 1060                 1065             


Gln Glu  Val His Thr Trp Arg  Val Gly Phe Phe Thr  Leu Val His 
    1070                 1075                 1080             


Phe Pro  Gln Glu His Ile Thr  Leu Leu Trp Asp Gln  Arg Thr Thr 
    1085                 1090                 1095             


Val His  Val Gln Ala Gly Pro  Gln Trp Gln Gly Gln  Leu Ala Gly 
    1100                 1105                 1110             


Leu Cys  Gly Asn Phe Asp Leu  Lys Thr Ile Asn Glu  Met Arg Thr 
    1115                 1120                 1125             


Pro Glu  Asn Leu Glu Leu Thr  Asn Pro Gln Glu Phe  Gly Ser Ser 
    1130                 1135                 1140             


Trp Ala  Ala Val Glu Cys Pro  Asp Thr Leu Asp Pro  Arg Asp Met 
    1145                 1150                 1155             


Cys Val  Leu Asn Pro Leu Arg  Glu Pro Phe Ala Lys  Lys Glu Cys 
    1160                 1165                 1170             


Ser Ile  Leu Leu Ser Glu Val  Phe Glu Ile Cys His  Pro Val Val 
    1175                 1180                 1185             


Asp Val  Thr Trp Phe Tyr Ser  Asn Cys Leu Thr Asp  Thr Cys Gly 
    1190                 1195                 1200             


Cys Ser  Gln Gly Gly Asp Cys  Glu Cys Phe Cys Ala  Ser Val Ser 
    1205                 1210                 1215             


Ala Tyr  Ala His Gln Cys Cys  Gln His Gly Val Ala  Val Asp Trp 
    1220                 1225                 1230             


Arg Thr  Pro Arg Leu Cys Pro  Tyr Asp Cys Asp Phe  Phe Asn Lys 
    1235                 1240                 1245             


Val Leu  Gly Lys Gly Pro Tyr  Gln Leu Ser Ser Leu  Ala Ala Gly 
    1250                 1255                 1260             


Gly Ala  Leu Val Gly Met Lys  Ala Val Gly Asp Asp  Ile Val Leu 
    1265                 1270                 1275             


Val Arg  Thr Glu Asp Val Ala  Pro Ala Asp Ile Val  Ser Phe Leu 
    1280                 1285                 1290             


Leu Thr  Ala Ala Leu Tyr Lys  Ala Lys Ala His Asp  Pro Asp Val 
    1295                 1300                 1305             


Val Ser  Leu Glu Ala Ala Asp  Arg Pro Asn Phe Phe  Leu His Val 
    1310                 1315                 1320             


Thr Ala  Asn Gly Ser Leu Glu  Leu Ala Lys Trp Gln  Gly Arg Asp 
    1325                 1330                 1335             


Thr Phe  Gln Gln His Ala Ser  Phe Leu Leu His Arg  Gly Thr Arg 
    1340                 1345                 1350             


Gln Ala  Gly Leu Val Ala Leu  Glu Ser Leu Ala Lys  Pro Ser Ser 
    1355                 1360                 1365             


Phe Leu  Tyr Val Ser Gly Ala  Val Leu Ala Leu Arg  Leu Tyr Glu 
    1370                 1375                 1380             


His Thr  Glu Val Phe Arg Arg  Gly Thr Leu Phe Arg  Leu Leu Asp 
    1385                 1390                 1395             


Ala Lys  Pro Ser Gly Ala Ala  Tyr Pro Ile Cys Glu  Trp Arg Tyr 
    1400                 1405                 1410             


Asp Ala  Cys Ala Ser Pro Cys  Phe Gln Thr Cys Arg  Asp Pro Arg 
    1415                 1420                 1425             


Ala Ala  Ser Cys Arg Asp Val  Pro Arg Val Glu Gly  Cys Val Pro 
    1430                 1435                 1440             


Val Cys  Pro Thr Pro Gln Val  Leu Asp Glu Val Thr  Gln Arg Cys 
    1445                 1450                 1455             


Val Tyr  Leu Glu Asp Cys Val  Glu Pro Ala Val Trp  Val Pro Thr 
    1460                 1465                 1470             


Glu Ala  Leu Gly Asn Glu Thr  Leu Pro Pro Ser Gln  Gly Leu Pro 
    1475                 1480                 1485             


Thr Pro  Ser Asp Glu Glu Pro  Gln Leu Ser Gln Glu  Ser Pro Arg 
    1490                 1495                 1500             


Thr Pro  Thr His Arg Pro Ala  Leu Thr Pro Ala Ala  Pro Leu Thr 
    1505                 1510                 1515             


Thr Ala  Leu Asn Pro Pro Val  Thr Ala Thr Glu Glu  Pro Val Val 
    1520                 1525                 1530             


Ser Pro  Gly Pro Thr Gln Thr  Thr Leu Gln Gln Pro  Leu Glu Leu 
    1535                 1540                 1545             


Thr Ala  Ser Gln Leu Pro Ala  Gly Pro Thr Glu Ser  Pro Ala Ser 
    1550                 1555                 1560             


Lys Gly  Val Thr Ala Ser Leu  Leu Ala Ile Pro His  Thr Pro Glu 
    1565                 1570                 1575             


Ser Ser  Ser Leu Pro Val Ala  Leu Gln Thr Pro Thr  Pro Gly Met 
    1580                 1585                 1590             


Val Ser  Gly Ala Met Glu Thr  Thr Arg Val Thr Val  Ile Phe Ala 
    1595                 1600                 1605             


Gly Ser  Pro Asn Ile Thr Val  Ser Ser Arg Ser Pro  Pro Ala Pro 
    1610                 1615                 1620             


Arg Phe  Pro Leu Met Thr Lys  Ala Val Thr Val Arg  Gly His Gly 
    1625                 1630                 1635             


Ser Leu  Pro Val Arg Thr Thr  Pro Pro Gln Pro Ser  Leu Thr Ala 
    1640                 1645                 1650             


Ser Pro  Ser Ser Arg Pro Val  Ala Ser Pro Gly Ala  Ile Ser Arg 
    1655                 1660                 1665             


Ser Pro  Thr Ser Ser Gly Ser  His Lys Ala Val Leu  Thr Pro Ala 
    1670                 1675                 1680             


Val Thr  Lys Val Ile Ser Arg  Thr Gly Val Pro Gln  Pro Thr Gln 
    1685                 1690                 1695             


Ala Gln  Ser Ala Ser Ser Pro  Ser Thr Pro Leu Thr  Val Ala Gly 
    1700                 1705                 1710             


Thr Ala  Ala Glu Gln Val Pro  Val Ser Pro Leu Ala  Thr Arg Ser 
    1715                 1720                 1725             


Leu Glu  Ile Val Leu Ser Thr  Glu Lys Gly Glu Ala  Gly His Ser 
    1730                 1735                 1740             


Gln Pro  Met Gly Ser Pro Ala  Ser Pro Gln Pro His  Pro Leu Pro 
    1745                 1750                 1755             


Ser Ala  Pro Pro Arg Pro Ala  Gln His Thr Thr Met  Ala Thr Arg 
    1760                 1765                 1770             


Ser Pro  Ala Leu Pro Pro Glu  Thr Pro Ala Ala Ala  Ser Leu Ser 
    1775                 1780                 1785             


Thr Ala  Thr Asp Gly Leu Ala  Ala Thr Pro Phe Met  Ser Leu Glu 
    1790                 1795                 1800             


Ser Thr  Arg Pro Ser Gln Leu  Leu Ser Gly Leu Pro  Pro Asp Thr 
    1805                 1810                 1815             


Ser Leu  Pro Leu Ala Lys Val  Gly Thr Ser Ala Pro  Val Ala Thr 
    1820                 1825                 1830             


Pro Gly  Pro Lys Ala Ser Val  Ile Thr Thr Pro Leu  Gln Pro Gln 
    1835                 1840                 1845             


Ala Thr  Thr Leu Pro Ala Gln  Thr Leu Ser Pro Val  Leu Pro Phe 
    1850                 1855                 1860             


Thr Pro  Ala Ala Met Thr Gln  Ala His Pro Pro Thr  His Ile Ala 
    1865                 1870                 1875             


Pro Pro  Ala Ala Gly Thr Ala  Pro Gly Leu Leu Leu  Gly Ala Thr 
    1880                 1885                 1890             


Leu Pro  Thr Ser Gly Val Leu  Pro Val Ala Glu Gly  Thr Ala Ser 
    1895                 1900                 1905             


Met Val  Ser Val Val Pro Arg  Lys Ser Thr Thr Gly  Lys Val Ala 
    1910                 1915                 1920             


Ile Leu  Ser Lys Gln Val Ser  Leu Pro Thr Ser Met  Tyr Gly Ser 
    1925                 1930                 1935             


Ala Glu  Gly Gly Pro Thr Glu  Leu Thr Pro Ala Thr  Ser His Pro 
    1940                 1945                 1950             


Leu Thr  Pro Leu Val Ala Glu  Pro Glu Gly Ala Gln  Ala Gly Thr 
    1955                 1960                 1965             


Ala Leu  Pro Val Pro Thr Ser  Tyr Ala Leu Ser Arg  Val Ser Ala 
    1970                 1975                 1980             


Arg Thr  Ala Pro Gln Asp Ser  Met Leu Val Leu Leu  Pro Gln Leu 
    1985                 1990                 1995             


Ala Glu  Ala His Gly Thr Ser  Ala Gly Pro His Leu  Ala Ala Glu 
    2000                 2005                 2010             


Pro Val  Asp Glu Ala Thr Thr  Glu Pro Ser Gly Arg  Ser Ala Pro 
    2015                 2020                 2025             


Ala Leu  Ser Ile Val Glu Gly  Leu Ala Glu Ala Leu  Ala Thr Thr 
    2030                 2035                 2040             


Thr Glu  Ala Asn Thr Ser Thr  Thr Cys Val Pro Ile  Ala Glu Gln 
    2045                 2050                 2055             


Asp Cys  Val Arg His Ile Cys  Leu Glu Gly Gln Leu  Ile Arg Val 
    2060                 2065                 2070             


Asn Gln  Ser Gln His Cys Pro  Gln Gly Ala Ala Pro  Pro Arg Cys 
    2075                 2080                 2085             


Gly Ile  Leu Gly Leu Ala Val  Arg Val Gly Gly Asp  Arg Cys Cys 
    2090                 2095                 2100             


Pro Leu  Trp Glu Cys Ala Cys  Arg Cys Ser Ile Phe  Pro Asp Leu 
    2105                 2110                 2115             


Ser Phe  Val Thr Phe Asp Gly  Ser His Val Ala Leu  Phe Lys Glu 
    2120                 2125                 2130             


Ala Ile  Tyr Ile Leu Ser Gln  Ser Pro Asp Glu Met  Leu Thr Val 
    2135                 2140                 2145             


His Val  Leu Asp Cys Lys Ser  Ala Asn Leu Gly His  Leu Asn Trp 
    2150                 2155                 2160             


Pro Pro  Phe Cys Leu Val Met  Leu Asn Met Thr His  Leu Ala His 
    2165                 2170                 2175             


Gln Val  Thr Ile Asp Arg Phe  Asn Arg Lys Val Thr  Val Asp Leu 
    2180                 2185                 2190             


Gln Pro  Val Trp Pro Pro Val  Ser Arg Tyr Gly Phe  Arg Ile Glu 
    2195                 2200                 2205             


Asp Thr  Gly His Met Tyr Met  Ile Leu Thr Pro Ser  Asp Ile Gln 
    2210                 2215                 2220             


Ile Gln  Trp Leu His Ser Ser  Gly Leu Met Ile Val  Glu Ala Ser 
    2225                 2230                 2235             


Lys Thr  Ser Lys Ala Gln Gly  His Gly Leu Cys Gly  Ile Cys Asp 
    2240                 2245                 2250             


Gly Asp  Ala Ala Asn Asp Leu  Thr Leu Lys Asp Gly  Ser Val Val 
    2255                 2260                 2265             


Gly Gly  Ala Glu Asp Pro Ala  Pro Phe Leu Asp Ser  Trp Gln Val 
    2270                 2275                 2280             


Pro Ser  Ser Leu Thr Ser Val  Gly Gln Thr Arg Phe  Arg Pro Asp 
    2285                 2290                 2295             


Ser Cys  Ala Thr Thr Asp Cys  Ser Pro Cys Leu Arg  Met Val Ser 
    2300                 2305                 2310             


Asn Arg  Thr Phe Ser Ala Cys  His Arg Phe Val Pro  Pro Glu Ser 
    2315                 2320                 2325             


Phe Cys  Glu Leu Trp Ile Arg  Asp Thr Lys Tyr Val  Gln Gln Pro 
    2330                 2335                 2340             


Cys Val  Ala Leu Thr Val Tyr  Val Ala Met Cys His  Lys Phe His 
    2345                 2350                 2355             


Val Cys  Ile Glu Trp Arg Arg  Ser Asp Tyr Cys Pro  Phe Leu Cys 
    2360                 2365                 2370             


Ser Ser  Asp Ser Thr Tyr Gln  Ala Cys Val Thr Ala  Cys Glu Pro 
    2375                 2380                 2385             


Pro Lys  Thr Cys Gln Asp Gly  Ile Leu Gly Pro Leu  Asp Pro Glu 
    2390                 2395                 2400             


His Cys  Gln Val Leu Gly Glu  Gly Cys Val Cys Ser  Glu Gly Thr 
    2405                 2410                 2415             


Ile Leu  His Arg Arg His Ser  Ala Leu Cys Ile Pro  Glu Ala Lys 
    2420                 2425                 2430             


Cys Ala  Cys Thr Asp Ser Met  Gly Val Pro Arg Ala  Leu Gly Glu 
    2435                 2440                 2445             


Thr Trp  Asn Ser Ser Leu Ser  Gly Cys Cys Gln His  Gln Cys Gln 
    2450                 2455                 2460             


Ala Pro  Asp Thr Ile Val Pro  Val Asp Leu Gly Cys  Pro Ser Pro 
    2465                 2470                 2475             


Arg Pro  Glu Ser Cys Leu Arg  Phe Gly Glu Val Ala  Leu Leu Leu 
    2480                 2485                 2490             


Pro Thr  Lys Asp Pro Cys Cys  Leu Gly Thr Val Cys  Val Cys Asn 
    2495                 2500                 2505             


Gln Thr  Leu Cys Glu Gly Leu  Ala Pro Thr Cys Arg  Pro Gly His 
    2510                 2515                 2520             


Arg Leu  Leu Thr His Phe Gln  Glu Asp Ser Cys Cys  Pro Ser Tyr 
    2525                 2530                 2535             


Ser Cys  Glu Cys Asp Pro Asp  Leu Cys Glu Ala Glu  Leu Val Pro 
    2540                 2545                 2550             


Ser Cys  Arg Gln Asp Gln Ile  Leu Ile Thr Gly Arg  Leu Gly Asp 
    2555                 2560                 2565             


Ser Cys  Cys Thr Ser Tyr Phe  Cys Ala Cys Gly Asp  Cys Pro Asp 
    2570                 2575                 2580             


Ser Ile  Pro Glu Cys Gln Glu  Gly Glu Ala Leu Thr  Val His Arg 
    2585                 2590                 2595             


Asn Thr  Thr Glu Leu Cys Cys  Pro Leu Tyr Gln Cys  Val Cys Glu 
    2600                 2605                 2610             


Asn Phe  Arg Cys Pro Gln Val  Gln Cys Gly Leu Gly  Thr Ala Leu 
    2615                 2620                 2625             


Val Glu  Val Trp Ser Pro Asp  Arg Cys Cys Pro Tyr  Lys Ser Cys 
    2630                 2635                 2640             


Glu Cys  Asp Cys Asp Thr Ile  Pro Val Pro Arg Cys  His Leu Trp 
    2645                 2650                 2655             


Glu Lys  Ser Gln Leu Asp Glu  Glu Phe Met His Ser  Val Glu Asn 
    2660                 2665                 2670             


Val Cys  Gly Cys Ala Lys Tyr  Glu Cys Val Lys Ala  Pro Val Cys 
    2675                 2680                 2685             


Leu Ser  Arg Glu Leu Gly Val  Met Gln Pro Gly Gln  Thr Val Val 
    2690                 2695                 2700             


Glu Leu  Ser Ala Asp Gly Val  Cys His Thr Ser Arg  Cys Thr Thr 
    2705                 2710                 2715             


Val Leu  Asp Pro Leu Thr Asn  Phe Tyr Gln Ile Asn  Thr Thr Ser 
    2720                 2725                 2730             


Val Leu  Cys Asp Ile His Cys  Glu Ala Asn Gln Glu  Tyr Glu His 
    2735                 2740                 2745             


Pro Arg  Asp Leu Ala Ala Cys  Cys Gly Ser Cys Arg  Asn Val Ser 
    2750                 2755                 2760             


Cys Leu  Phe Thr Phe Pro Asn  Gly Thr Thr Ser Leu  Phe Leu Pro 
    2765                 2770                 2775             


Gly Ala  Ser Trp Ile Ala Asp  Cys Ala Arg His His  Cys Ser Ser 
    2780                 2785                 2790             


Thr Pro  Leu Gly Ala Val Leu  Val Arg Ser Pro Ile  Ser Cys Pro 
    2795                 2800                 2805             


Pro Leu  Asn Glu Thr Glu Cys  Ala Lys Val Gly Gly  Ser Val Val 
    2810                 2815                 2820             


Pro Ser  Leu Glu Gly Cys Cys  Arg Thr Cys Lys Glu  Asp Gly Arg 
    2825                 2830                 2835             


Ser Cys  Lys Lys Val Thr Ile  Arg Met Thr Ile Arg  Lys Asn Glu 
    2840                 2845                 2850             


Cys Arg  Ser Ser Thr Pro Val  Asn Leu Val Ser Cys  Asp Gly Arg 
    2855                 2860                 2865             


Cys Pro  Ser Ala Ser Ile Tyr  Asn Tyr Asn Ile Asn  Thr Tyr Ala 
    2870                 2875                 2880             


Arg Phe  Cys Lys Cys Cys Arg  Glu Val Gly Leu Gln  Arg Arg Ser 
    2885                 2890                 2895             


Val Gln  Leu Phe Cys Ala Thr  Asn Ala Thr Trp Val  Pro Tyr Thr 
    2900                 2905                 2910             


Val Gln  Glu Pro Thr Asp Cys  Ala Cys Gln Trp Ser  
    2915                 2920                 2925 


<210>  9872
<211>  71
<212>  PRT
<213>  Homo Sapiens

<400>  9872

Gly Glu Phe Leu Thr Val Asp Leu Asn Ser Thr His Phe Cys Cys Pro 
1               5                   10                  15      


Gln Tyr Tyr Cys Val Cys Glu Pro Asn Leu Cys Pro Met Pro Leu Leu 
            20                  25                  30          


Asn Cys Ala Glu Asp Met Asn Leu Val Lys Glu Asn Val Ser Gly Gln 
        35                  40                  45              


Cys Cys Pro Thr Trp His Cys Glu Cys Asn Cys Glu Asn Leu Ile Met 
    50                  55                  60                  


Pro Thr Cys Glu Val Ile Ser 
65                  70      


<210>  9873
<211>  2344
<212>  PRT
<213>  Homo Sapiens

<400>  9873

Met Ile Pro Trp Ser Ile Phe Leu Leu His Val Leu Leu Phe Ser Leu 
1               5                   10                  15      


Gln Glu Tyr Ile Cys Ala Ser Ser Ile Leu Met Gly Thr Ser Lys Asn 
            20                  25                  30          


Gly Phe Asn Glu Asn Arg Gln Lys Arg Ala Leu Leu Ala Ala Gln Phe 
        35                  40                  45              


Glu Ala Thr Ser Pro Arg Tyr Phe Phe His Asp Ala Ile Asn Trp Gly 
    50                  55                  60                  


Glu Ser Lys Ile Lys Gly Ser Cys Pro Tyr Glu Cys Leu Asn Gly Ala 
65                  70                  75                  80  


Phe Cys Ser Lys Thr Gly Thr Cys Asp Cys Gln Ile Phe Gln Ala Leu 
                85                  90                  95      


Gly Thr Arg Cys Gln Ile Ile Pro Asn Met Gly Asn Gly Arg Asp Gly 
            100                 105                 110         


Ile Cys Lys Thr Trp Gly Gln Tyr His Phe Glu Thr Phe Asp Gly Ile 
        115                 120                 125             


Tyr Tyr Tyr Phe Pro Gly Asn Cys Ser Tyr Ile Phe Ala Lys Asp Cys 
    130                 135                 140                 


Gly Asp Leu Glu Pro Arg Tyr Thr Val Trp Val His Asn Ser Pro Lys 
145                 150                 155                 160 


Cys Leu Gly Ser Val Tyr Ser Cys Tyr Arg Ser Ile Ser Leu Phe Phe 
                165                 170                 175     


Ser Asn Gln Glu Glu Ile Arg Ile Tyr Gly His Glu Ile Lys Lys Asn 
            180                 185                 190         


Gly Ile Ser Leu Thr Leu Pro Gln Thr Ile Gly Gln Ile Phe Ile Glu 
        195                 200                 205             


Lys Leu Ala Asp Tyr Ile Leu Val Lys Thr Thr Phe Gly Phe Ser Leu 
    210                 215                 220                 


Ala Trp Asp Gly Ile Ser Gly Ile Tyr Leu Lys Leu Ser Glu Asp His 
225                 230                 235                 240 


Lys Gly Lys Ser Cys Gly Leu Cys Gly Asn Tyr Asn Asp Ile Gln Ser 
                245                 250                 255     


Asp Asp Phe Ile Ile Leu Gln Glu Asp Tyr Thr Glu Asp Ile Ala Met 
            260                 265                 270         


Phe Ala Asn Ser Trp Ser Val Gln Thr Pro Asp Asp Thr Lys Cys Val 
        275                 280                 285             


Leu Thr Pro Ser Asp Phe Pro Asn Pro Cys Ser Ser Gly Met Pro Ala 
    290                 295                 300                 


Phe Glu Ala Ile Phe Phe Lys Cys Gln Ile Leu Leu Gln Phe Pro Phe 
305                 310                 315                 320 


Leu Ser Cys His Glu Tyr Ile Asp Pro Tyr Leu Tyr Ile Ala Ser Cys 
                325                 330                 335     


Val Asn Asp Leu Cys Lys Thr Asp Asp Asp Glu Thr Tyr Cys Arg Ala 
            340                 345                 350         


Ala Thr Glu Tyr Ala Arg Ala Cys Ser His Ala Gly Tyr Pro Ile Gln 
        355                 360                 365             


Asp Trp Arg Asp Asp Phe Pro Ala Cys Thr Asp Lys Cys Asp Asp Ser 
    370                 375                 380                 


Phe Val His Arg Asp Cys Ile Ser Cys Cys Pro Pro Thr Cys Thr Phe 
385                 390                 395                 400 


Glu Lys Gln Cys Leu Gly Ser Asn Leu His Cys Leu Asp Gly Cys Tyr 
                405                 410                 415     


Cys Pro Asp Gly Leu Val Met Asp Asn Gly Thr Cys Ile Ser Leu Glu 
            420                 425                 430         


Asn Cys Pro Cys Gly Phe His Gly Leu Ala Tyr Ser Val Gly Ser Lys 
        435                 440                 445             


Ile Glu Gln Glu Cys Thr Glu Cys Val Cys Val Gly Gly Val Trp Asn 
    450                 455                 460                 


Cys Thr Glu Gln Asp Cys Pro Val Gln Cys Ser Val Val Gly Asp Ser 
465                 470                 475                 480 


His Phe Thr Thr Phe Asp Gly Arg His Tyr Ser Phe Ile Gly Met Cys 
                485                 490                 495     


Gln Tyr Ile Leu Val Lys Gly Thr Gly Lys Asp Lys Phe Thr Ile Thr 
            500                 505                 510         


Leu Gln Lys Ala Pro Cys Glu Gln Asn Leu Gly Leu Val Cys Leu Gln 
        515                 520                 525             


Ser Ile Thr Leu Ile Leu Glu Asp Asp Phe Asn Lys Gln Val Thr Leu 
    530                 535                 540                 


Gly Arg Gly Gly Gln Ile Leu Thr Ser Pro Asn Gln Gly Phe Asn Leu 
545                 550                 555                 560 


Asn Gly Ile Val Glu Ile Gln Thr Leu Ser Ser Leu Phe Ile Leu Leu 
                565                 570                 575     


Lys Thr Thr Phe Gly Leu Lys Ile Leu Phe Ala Ile Asp Gly Glu Arg 
            580                 585                 590         


Ile Tyr Ile Gln Leu Thr Ser Ala Trp Lys Arg Arg Thr Leu Gly Leu 
        595                 600                 605             


Cys Gly Thr Phe Asn Gly Asn Ile Arg Asp Asp Phe Leu Ser Pro Ser 
    610                 615                 620                 


Gly Met Ile Glu Gly Thr Pro Gln Leu His Ala Asn Ala Trp Arg Val 
625                 630                 635                 640 


Ser Ser Thr Cys Phe Ala Pro Val His Val Pro Val Val Asp Pro Cys 
                645                 650                 655     


Asn Ile Asn Gln Gln Asn Ile Gly Tyr Ala Ala His Cys Asp Val Ile 
            660                 665                 670         


His Gln Glu Leu Phe Ala Pro Cys His Ile Tyr Ile Ser Pro Gly Leu 
        675                 680                 685             


Tyr Tyr Gln Leu Cys Arg His Asp Ala Cys Lys Cys Gly Ser Ser Cys 
    690                 695                 700                 


Leu Cys Asn Ala Leu Ala His Tyr Ala Tyr Leu Cys Gly Gln His Gly 
705                 710                 715                 720 


Val Pro Ile Asp Phe Arg Thr Gln Ile Ser Phe Cys Ala Val Val Cys 
                725                 730                 735     


Gln Lys Gly Met Leu Tyr His His Cys Ser Ser Phe Cys Leu His Ser 
            740                 745                 750         


Cys Ile Ser Leu Ser Ser Pro Glu Gln Cys Ser Asp Asp Cys Ala Glu 
        755                 760                 765             


Gly Cys Asn Cys Pro Glu Gly Lys Phe Tyr Glu Asp Thr Leu Asn Phe 
    770                 775                 780                 


Cys Val Pro Ile Phe His Cys Arg Cys His Tyr Arg Gly Ser Val Tyr 
785                 790                 795                 800 


Gln Pro Gly Glu Leu Ile Pro Thr Pro Ser Gly Leu Cys Gln Cys Ser 
                805                 810                 815     


Asn Gly Thr Val Lys Cys Asp Glu Leu Ala Thr Pro Ser Ala Val His 
            820                 825                 830         


Ile Cys Pro Glu Gly Lys Glu Tyr Phe Asp Cys Arg Phe Pro Asp Pro 
        835                 840                 845             


Glu Leu Pro Ala Gly Gly Val Asn Cys Glu Thr Thr Cys Ala Asn Leu 
    850                 855                 860                 


Ala Met Asn Phe Thr Cys Thr Pro Ser Ser Pro Cys Ile Ser Gly Cys 
865                 870                 875                 880 


Val Cys Ala Pro Gly Met Ala Glu His Arg Gly Lys Cys Tyr Val Pro 
                885                 890                 895     


Glu Ser Cys Pro Cys Ile Trp Lys Asp Trp Glu Tyr Leu Ser Gly Glu 
            900                 905                 910         


Val Ile Ala Thr Pro Cys Tyr Thr Cys Val Cys Arg Arg Gly Met Phe 
        915                 920                 925             


Asn Cys Thr Tyr Tyr Pro Cys Pro Ala Val Cys Thr Ile Tyr Gly Asp 
    930                 935                 940                 


Arg His Tyr Tyr Ser Phe Asp Gly Leu Glu Tyr Asp Tyr Ile Ser Asp 
945                 950                 955                 960 


Cys Gln Val Phe Leu Ile Lys Ser Ala Asp Asp Ser Asp Ile Ser Val 
                965                 970                 975     


Ile Ala Gln Asn Lys Lys Cys Phe Asp Asn Asp Ile Val Cys Ser Lys 
            980                 985                 990         


Ser Val Leu Ile Ser Val Gly Asp  Thr Glu Ile Tyr Leu  Asn Asp Thr 
        995                 1000                 1005             


Pro Tyr  Lys Gln Lys Gln Ser  Gly Phe Phe Leu Glu  Asn Lys Ser 
    1010                 1015                 1020             


Thr Tyr  Gln Leu Trp Lys Ala  Gly Tyr Tyr Ile Val  Val Tyr Phe 
    1025                 1030                 1035             


Pro Glu  Lys Asp Ile Thr Ile  Leu Trp Asp Arg Lys  Thr Thr Ile 
    1040                 1045                 1050             


His Ile  Lys Val Gly Pro Gln  Trp Lys Asn Lys Leu  Ser Gly Leu 
    1055                 1060                 1065             


Cys Gly  Asn Phe Asp Lys Cys  Thr Ser Asn Asp Met  Thr Thr Ser 
    1070                 1075                 1080             


Asn Asn  Leu Glu Val Arg Asn  Ala Arg Val Phe Gly  Asp Ser Trp 
    1085                 1090                 1095             


Ala Leu  Gly Gln Cys Glu Ser  Pro Asp Glu Thr Ile  Lys Pro Cys 
    1100                 1105                 1110             


Glu Ala  His Gln Asn Lys Phe  Pro Tyr Ala Lys Lys  Glu Cys Ser 
    1115                 1120                 1125             


Ile Leu  Tyr Ser Asp Ile Phe  Ala Ser Cys Arg Asn  Val Ile Asp 
    1130                 1135                 1140             


Val Thr  Ser Phe Ala Lys Asn  Cys His Glu Asp Thr  Cys Asn Cys 
    1145                 1150                 1155             


Asn Leu  Gly Gly Asp Cys Glu  Cys Leu Cys Thr Ser  Ile Ala Ala 
    1160                 1165                 1170             


Tyr Ala  Tyr Lys Cys Cys Gln  Glu Gly Ile Ser Ile  His Trp Arg 
    1175                 1180                 1185             


Ser Ser  Thr Val Cys Ser Leu  Asp Cys Glu Tyr Tyr  Asn Glu Gly 
    1190                 1195                 1200             


Leu Gly  Glu Gly Pro Tyr Met  Leu Ala Ser Tyr Gly  Gln Ser Gly 
    1205                 1210                 1215             


Leu Val  Leu Gly Ala Asn Met  Thr Ser Arg Ser Val  Phe Cys Leu 
    1220                 1225                 1230             


Pro Arg  Ser Ser Val His Thr  Ser Leu Phe Phe Tyr  Phe Met Ile 
    1235                 1240                 1245             


Thr Pro  Gly Leu Phe Lys Glu  Lys Val Ser Ser Leu  Ala Leu Val 
    1250                 1255                 1260             


Ser Leu  Glu Ser Ala Glu Arg  Pro Asn Tyr Phe Leu  Tyr Val His 
    1265                 1270                 1275             


Asp Asn  Asp Thr Leu Ser Leu  Glu Leu Trp Glu Ala  Asn Ser Ala 
    1280                 1285                 1290             


Phe His  Arg Arg Ala Thr Phe  Phe His His Gln Gly  Leu Trp Ile 
    1295                 1300                 1305             


Pro Gly  Tyr Ser Ala Phe Glu  Leu Tyr Ser Lys Lys  Gly Phe Phe 
    1310                 1315                 1320             


Ile Ile  Phe Thr Asp Ser Ser  Val Lys Ala Ser Lys  Tyr Asp Asp 
    1325                 1330                 1335             


Ser Glu  Glu Phe Lys His Ser  Ser Ser Phe Ser Ile  Glu Glu Ile 
    1340                 1345                 1350             


Gln Ala  Ala Val Pro Tyr Arg  Lys Met Cys Glu Trp  Arg Tyr Glu 
    1355                 1360                 1365             


Pro Cys  Ala Thr Pro Cys Phe  Lys Thr Cys Ser Asp  Pro Glu Ala 
    1370                 1375                 1380             


Leu Ala  Cys Lys Phe Leu Pro  Pro Val Glu Gly Cys  Leu Pro Tyr 
    1385                 1390                 1395             


Cys Pro  Lys Asn Met Ile Leu  Asp Glu Val Thr Leu  Lys Cys Val 
    1400                 1405                 1410             


Tyr Pro  Arg Asp Cys Ile Pro  Val Ile Pro Thr Glu  Pro Thr Leu 
    1415                 1420                 1425             


Met Pro  Pro Ala Lys Pro Thr  Val Pro Met Phe Thr  Val Trp Glu 
    1430                 1435                 1440             


Met Ile  Thr Pro Ser Asp Ile  Thr Val Phe Asp Met  Leu Thr Pro 
    1445                 1450                 1455             


Thr Thr  Gly Leu Glu Cys Glu  Pro Gln Lys Phe Asp  Pro Val Tyr 
    1460                 1465                 1470             


Asp Cys  Ser Gln Tyr Ile Cys  Leu Asn Met Glu Trp  Gln Leu Tyr 
    1475                 1480                 1485             


Asn Trp  Ser Leu Asn Cys Pro  Lys Asp Val Glu Met  Pro Asp Cys 
    1490                 1495                 1500             


Gly Phe  Arg Gly Arg Pro Val  Gln Val Asn Ser Asp  Ile Cys Cys 
    1505                 1510                 1515             


Pro Glu  Trp Glu Cys Pro Cys  Arg Cys Ser Met Leu  Ser Glu Leu 
    1520                 1525                 1530             


Ser Ile  Ile Thr Phe Asp Gly  Asn Asn Ala Ala Leu  Tyr Ser Met 
    1535                 1540                 1545             


Ala Ser  Tyr Ile Leu Val Arg  Ile Pro Gly Glu Ile  Ile Val Ala 
    1550                 1555                 1560             


His Ile  Glu Lys Cys Ser Met  Asn Gln Asn Gly Asn  Ser Leu Lys 
    1565                 1570                 1575             


Lys Leu  Ala Pro Ser Gly Arg  Ile Ser Gly Leu Cys  Phe Lys Lys 
    1580                 1585                 1590             


Leu Asn  Val Thr Thr Pro Ile  His Lys Ile Ile Val  Asn Arg Leu 
    1595                 1600                 1605             


Ala Arg  Lys Val Glu Val Asp  Ser Ile Val Val Pro  Leu Pro Phe 
    1610                 1615                 1620             


Ser Ser  Gln Glu Leu Ser Ile  Glu Asp Ser Gly Ser  Met Tyr Val 
    1625                 1630                 1635             


Ile Thr  Thr Pro Ala Gly Leu  Ile Ile Lys Trp Ser  His Leu Thr 
    1640                 1645                 1650             


Gly Ile  Ile Asp Ile His Phe  Gly Phe Arg Phe Asn  Leu Ser Ser 
    1655                 1660                 1665             


Tyr Thr  Glu Gly Leu Cys Gly  Ile Cys Asn Glu Asp  Pro Asp Asp 
    1670                 1675                 1680             


Asp Leu  Arg Met Gln Asn Gly  Thr Ile Ile Thr Asn  Met Glu Asp 
    1685                 1690                 1695             


Ile Gly  Leu Phe Ile Glu Ser  Trp Glu Ile Glu Lys  Ser Phe Glu 
    1700                 1705                 1710             


Val Thr  Met Arg Arg Pro Val  Arg Asn Cys Thr Glu  His Asp Cys 
    1715                 1720                 1725             


Ser Gln  Cys Ile Asp Leu Leu  Asn Arg Arg Ile Phe  Ile Pro Cys 
    1730                 1735                 1740             


His Asp  Lys Val Ser Pro Glu  Asp Phe Cys Glu Lys  Met Trp Ile 
    1745                 1750                 1755             


Asn Tyr  Thr Tyr Phe Trp Asn  Tyr Glu Cys Asp Ala  Leu Ser Ala 
    1760                 1765                 1770             


Tyr Val  Ala Leu Cys Asn Lys  Phe Asp Ile Cys Ile  Gln Trp Arg 
    1775                 1780                 1785             


Thr Pro  Asp Tyr Cys Ser Leu  Ser Cys Pro Glu Gly  Lys Glu Tyr 
    1790                 1795                 1800             


Gln Pro  Cys Val Arg Pro Cys  Glu Ala Arg Thr Cys  Leu Asn Gln 
    1805                 1810                 1815             


Trp Phe  Tyr Gly His Thr Ser  Cys Leu Asn Leu Arg  Glu Asp Cys 
    1820                 1825                 1830             


Val Cys  Lys Val Gly Thr Ile  Leu His Arg Pro His  Ser Ala Gln 
    1835                 1840                 1845             


Cys Ile  Pro Glu Lys Glu Cys  Ala Cys Thr Asp Ser  Glu Asp Gln 
    1850                 1855                 1860             


Pro Arg  Thr Ala Gly Glu Ile  Trp Asn Gly Gly Ile  Asp Glu Cys 
    1865                 1870                 1875             


Thr Leu  Tyr Lys Cys Leu Glu  Asn Gly Ser Ile Ile  Pro Ile Glu 
    1880                 1885                 1890             


Pro Asp  Cys Asp Glu Glu Pro  Thr Pro Val Cys Glu  Arg Glu Ala 
    1895                 1900                 1905             


Glu Val  Val Met Gly Ile Ile  Asp Lys Trp Thr Cys  Cys Ser Lys 
    1910                 1915                 1920             


Glu Val  Cys Gly Cys Asp Thr  Thr Leu Cys Glu Thr  Ser Ile Pro 
    1925                 1930                 1935             


Thr Cys  Thr Asn Ser Gln Lys  Leu Ile Val Gly His  Ser Pro Leu 
    1940                 1945                 1950             


Ser Cys  Cys Pro Gln Tyr Lys  Cys Glu Cys Asp Pro  Leu Lys Cys 
    1955                 1960                 1965             


Pro Ser  Ile Ser Thr Pro Glu  Cys Arg Glu Asp Gln  Phe Met Ile 
    1970                 1975                 1980             


Gln Val  Arg Gln Glu Glu Pro  Cys Cys Phe Ser Pro  Phe Cys Val 
    1985                 1990                 1995             


Cys Glu  Ser Cys Thr Lys Pro  Val Pro Leu Cys His  Asp Gly Glu 
    2000                 2005                 2010             


Phe Leu  Thr Val Asp Leu Asn  Ser Thr His Phe Cys  Cys Pro Gln 
    2015                 2020                 2025             


Tyr Tyr  Cys Val Cys Glu Pro  Asn Leu Cys Pro Met  Pro Leu Leu 
    2030                 2035                 2040             


Asn Cys  Ala Glu Asp Met Asn  Leu Val Lys Glu Asn  Val Ser Gly 
    2045                 2050                 2055             


Gln Cys  Cys Pro Thr Trp His  Cys Glu Cys Asn Cys  Glu Asn Leu 
    2060                 2065                 2070             


Ile Met  Pro Thr Cys Glu Val  Gly Glu Phe Thr Ala  Ile Asp His 
    2075                 2080                 2085             


Asn Phe  Gln Ser Asp Cys Gly  Cys Ile Gln Tyr Leu  Cys Glu Lys 
    2090                 2095                 2100             


Asp Asp  Val Cys Val Phe Gln  Glu Val Ser Val Leu  Asn Pro Gly 
    2105                 2110                 2115             


Gln Ser  Met Ile Lys Tyr Leu  Glu Glu Asp Phe Cys  Tyr Ala Ile 
    2120                 2125                 2130             


Glu Cys  Leu Glu Glu Lys Asp  Asn His Thr Gly Phe  His Thr Leu 
    2135                 2140                 2145             


Asn Phe  Thr Leu Val Asn Cys  Ser Lys Lys Cys Asp  Val His Gln 
    2150                 2155                 2160             


Val Tyr  Thr Pro Ser Pro Ser  Asp Tyr Gly Cys Cys  Gly Thr Cys 
    2165                 2170                 2175             


Lys Asn  Val Ser Cys Lys Phe  His Met Glu Asn Gly  Thr Ser Val 
    2180                 2185                 2190             


Val Tyr  Ala Val Gly Ser Thr  Trp His Tyr Asn Cys  Thr Thr Tyr 
    2195                 2200                 2205             


Glu Cys  Val Lys Thr Asp Glu  Gly Ala Ile Ile Leu  Asn Tyr Thr 
    2210                 2215                 2220             


Met Val  Cys Pro Pro Phe Asn  Glu Thr Glu Cys Lys  Met Asn Glu 
    2225                 2230                 2235             


Gly Ile  Val Lys Leu Tyr Asn  Glu Gly Cys Cys Lys  Ile Cys Lys 
    2240                 2245                 2250             


Arg Glu  Glu Arg Ile Cys Gln  Lys Val Ile Ile Lys  Ser Val Ile 
    2255                 2260                 2265             


Arg Lys  Gln Asp Cys Met Ser  Gln Ser Pro Ile Asn  Val Ala Ser 
    2270                 2275                 2280             


Cys Asp  Gly Lys Cys Pro Ser  Ala Thr Ile Tyr Asn  Ile Asn Ile 
    2285                 2290                 2295             


Glu Ser  His Leu Arg Phe Cys  Lys Cys Cys Arg Glu  Asn Gly Val 
    2300                 2305                 2310             


Arg Asn  Leu Ser Val Pro Leu  Tyr Cys Ser Gly Asn  Gly Thr Glu 
    2315                 2320                 2325             


Ile Met  Tyr Thr Leu Gln Glu  Pro Ile Asp Cys Thr  Cys Gln Trp 
    2330                 2335                 2340             


Asn 
    


<210>  9874
<211>  2353
<212>  PRT
<213>  Homo Sapiens

<400>  9874

Met Asn Ile Val Arg Lys Leu Asn Leu Met Ile Pro Trp Ser Ile Phe 
1               5                   10                  15      


Leu Leu His Val Leu Leu Phe Ser Leu Gln Glu Tyr Ile Cys Ala Ser 
            20                  25                  30          


Ser Ile Leu Met Gly Thr Ser Lys Asn Gly Phe Asn Glu Asn Arg Gln 
        35                  40                  45              


Lys Arg Ala Leu Leu Ala Ala Gln Phe Glu Ala Thr Ser Pro Arg Tyr 
    50                  55                  60                  


Phe Phe His Asp Ala Ile Asn Trp Gly Glu Ser Lys Ile Lys Gly Ser 
65                  70                  75                  80  


Cys Pro Tyr Glu Cys Leu Asn Gly Ala Phe Cys Ser Lys Thr Gly Thr 
                85                  90                  95      


Cys Asp Cys Gln Ile Phe Gln Ala Leu Gly Thr Arg Cys Gln Ile Ile 
            100                 105                 110         


Pro Asn Met Gly Asn Gly Arg Asp Gly Ile Cys Lys Thr Trp Gly Gln 
        115                 120                 125             


Tyr His Phe Glu Thr Phe Asp Gly Ile Tyr Tyr Tyr Phe Pro Gly Asn 
    130                 135                 140                 


Cys Ser Tyr Ile Phe Ala Lys Asp Cys Gly Asp Leu Glu Pro Arg Tyr 
145                 150                 155                 160 


Thr Val Trp Val His Asn Ser Pro Lys Cys Leu Gly Ser Val Tyr Ser 
                165                 170                 175     


Cys Tyr Arg Ser Ile Ser Leu Phe Phe Ser Asn Gln Glu Glu Ile Arg 
            180                 185                 190         


Ile Tyr Gly His Glu Ile Lys Lys Asn Gly Ile Ser Leu Thr Leu Pro 
        195                 200                 205             


Gln Thr Ile Gly Gln Ile Phe Ile Glu Lys Leu Ala Asp Tyr Ile Leu 
    210                 215                 220                 


Val Lys Thr Thr Phe Gly Phe Ser Leu Ala Trp Asp Gly Ile Ser Gly 
225                 230                 235                 240 


Ile Tyr Leu Lys Leu Ser Glu Asp His Lys Gly Lys Ser Cys Gly Leu 
                245                 250                 255     


Cys Gly Asn Tyr Asn Asp Ile Gln Ser Asp Asp Phe Ile Ile Leu Gln 
            260                 265                 270         


Glu Asp Tyr Thr Glu Asp Ile Ala Met Phe Ala Asn Ser Trp Ser Val 
        275                 280                 285             


Gln Thr Pro Asp Asp Thr Lys Cys Val Leu Thr Pro Ser Asp Phe Pro 
    290                 295                 300                 


Asn Pro Cys Ser Ser Gly Met Pro Ala Phe Glu Ala Ile Phe Phe Lys 
305                 310                 315                 320 


Cys Gln Ile Leu Leu Gln Phe Pro Phe Leu Ser Cys His Glu Tyr Ile 
                325                 330                 335     


Asp Pro Tyr Leu Tyr Ile Ala Ser Cys Val Asn Asp Leu Cys Lys Thr 
            340                 345                 350         


Asp Asp Asp Glu Thr Tyr Cys Arg Ala Ala Thr Glu Tyr Ala Arg Ala 
        355                 360                 365             


Cys Ser His Ala Gly Tyr Pro Ile Gln Asp Trp Arg Asp Asp Phe Pro 
    370                 375                 380                 


Ala Cys Thr Asp Lys Cys Asp Asp Ser Phe Val His Arg Asp Cys Ile 
385                 390                 395                 400 


Ser Cys Cys Pro Pro Thr Cys Thr Phe Glu Lys Gln Cys Leu Gly Ser 
                405                 410                 415     


Asn Leu His Cys Leu Asp Gly Cys Tyr Cys Pro Asp Gly Leu Val Met 
            420                 425                 430         


Asp Asn Gly Thr Cys Ile Ser Leu Glu Asn Cys Pro Cys Gly Phe His 
        435                 440                 445             


Gly Leu Ala Tyr Ser Val Gly Ser Lys Ile Glu Gln Glu Cys Thr Glu 
    450                 455                 460                 


Cys Val Cys Val Gly Gly Val Trp Asn Cys Thr Glu Gln Asp Cys Pro 
465                 470                 475                 480 


Val Gln Cys Ser Val Val Gly Asp Ser His Phe Thr Thr Phe Asp Gly 
                485                 490                 495     


Arg His Tyr Ser Phe Ile Gly Met Cys Gln Tyr Ile Leu Val Lys Gly 
            500                 505                 510         


Thr Gly Lys Asp Lys Phe Thr Ile Thr Leu Gln Lys Ala Pro Cys Glu 
        515                 520                 525             


Gln Asn Leu Gly Leu Val Cys Leu Gln Ser Ile Thr Leu Ile Leu Glu 
    530                 535                 540                 


Asp Asp Phe Asn Lys Gln Val Thr Leu Gly Arg Gly Gly Gln Ile Leu 
545                 550                 555                 560 


Thr Ser Pro Asn Gln Gly Phe Asn Leu Asn Gly Ile Val Glu Ile Gln 
                565                 570                 575     


Thr Leu Ser Ser Leu Phe Ile Leu Leu Lys Thr Thr Phe Gly Leu Lys 
            580                 585                 590         


Ile Leu Phe Ala Ile Asp Gly Glu Arg Ile Tyr Ile Gln Leu Thr Ser 
        595                 600                 605             


Ala Trp Lys Arg Arg Thr Leu Gly Leu Cys Gly Thr Phe Asn Gly Asn 
    610                 615                 620                 


Ile Arg Asp Asp Phe Leu Ser Pro Ser Gly Met Ile Glu Gly Thr Pro 
625                 630                 635                 640 


Gln Leu His Ala Asn Ala Trp Arg Val Ser Ser Thr Cys Phe Ala Pro 
                645                 650                 655     


Val His Val Pro Val Val Asp Pro Cys Asn Ile Asn Gln Gln Asn Ile 
            660                 665                 670         


Gly Tyr Ala Ala His Cys Asp Val Ile His Gln Glu Leu Phe Ala Pro 
        675                 680                 685             


Cys His Ile Tyr Ile Ser Pro Gly Leu Tyr Tyr Gln Leu Cys Arg His 
    690                 695                 700                 


Asp Ala Cys Lys Cys Gly Ser Ser Cys Leu Cys Asn Ala Leu Ala His 
705                 710                 715                 720 


Tyr Ala Tyr Leu Cys Gly Gln His Gly Val Pro Ile Asp Phe Arg Thr 
                725                 730                 735     


Gln Ile Ser Phe Cys Ala Val Val Cys Gln Lys Gly Met Leu Tyr His 
            740                 745                 750         


His Cys Ser Ser Phe Cys Leu His Ser Cys Ile Ser Leu Ser Ser Pro 
        755                 760                 765             


Glu Gln Cys Ser Asp Asp Cys Ala Glu Gly Cys Asn Cys Pro Glu Gly 
    770                 775                 780                 


Lys Phe Tyr Glu Asp Thr Leu Asn Phe Cys Val Pro Ile Phe His Cys 
785                 790                 795                 800 


Arg Cys His Tyr Arg Gly Ser Val Tyr Gln Pro Gly Glu Leu Ile Pro 
                805                 810                 815     


Thr Pro Ser Gly Leu Cys Gln Cys Ser Asn Gly Thr Val Lys Cys Asp 
            820                 825                 830         


Glu Leu Ala Thr Pro Ser Ala Val His Ile Cys Pro Glu Gly Lys Glu 
        835                 840                 845             


Tyr Phe Asp Cys Arg Phe Pro Asp Pro Glu Leu Pro Ala Gly Gly Val 
    850                 855                 860                 


Asn Cys Glu Thr Thr Cys Ala Asn Leu Ala Met Asn Phe Thr Cys Thr 
865                 870                 875                 880 


Pro Ser Ser Pro Cys Ile Ser Gly Cys Val Cys Ala Pro Gly Met Ala 
                885                 890                 895     


Glu His Arg Gly Lys Cys Tyr Val Pro Glu Ser Cys Pro Cys Ile Trp 
            900                 905                 910         


Lys Asp Trp Glu Tyr Leu Ser Gly Glu Val Ile Ala Thr Pro Cys Tyr 
        915                 920                 925             


Thr Cys Val Cys Arg Arg Gly Met Phe Asn Cys Thr Tyr Tyr Pro Cys 
    930                 935                 940                 


Pro Ala Val Cys Thr Ile Tyr Gly Asp Arg His Tyr Tyr Ser Phe Asp 
945                 950                 955                 960 


Gly Leu Glu Tyr Asp Tyr Ile Ser Asp Cys Gln Val Phe Leu Ile Lys 
                965                 970                 975     


Ser Ala Asp Asp Ser Asp Ile Ser Val Ile Ala Gln Asn Lys Lys Cys 
            980                 985                 990         


Phe Asp Asn Asp Ile Val Cys Ser  Lys Ser Val Leu Ile  Ser Val Gly 
        995                 1000                 1005             


Asp Thr  Glu Ile Tyr Leu Asn  Asp Thr Pro Tyr Lys  Gln Lys Gln 
    1010                 1015                 1020             


Ser Gly  Phe Phe Leu Glu Asn  Lys Ser Thr Tyr Gln  Leu Trp Lys 
    1025                 1030                 1035             


Ala Gly  Tyr Tyr Ile Val Val  Tyr Phe Pro Glu Lys  Asp Ile Thr 
    1040                 1045                 1050             


Ile Leu  Trp Asp Arg Lys Thr  Thr Ile His Ile Lys  Val Gly Pro 
    1055                 1060                 1065             


Gln Trp  Lys Asn Lys Leu Ser  Gly Leu Cys Gly Asn  Phe Asp Lys 
    1070                 1075                 1080             


Cys Thr  Ser Asn Asp Met Thr  Thr Ser Asn Asn Leu  Glu Val Arg 
    1085                 1090                 1095             


Asn Ala  Arg Val Phe Gly Asp  Ser Trp Ala Leu Gly  Gln Cys Glu 
    1100                 1105                 1110             


Ser Pro  Asp Glu Thr Ile Lys  Pro Cys Glu Ala His  Gln Asn Lys 
    1115                 1120                 1125             


Phe Pro  Tyr Ala Lys Lys Glu  Cys Ser Ile Leu Tyr  Ser Asp Ile 
    1130                 1135                 1140             


Phe Ala  Ser Cys Arg Asn Val  Ile Asp Val Thr Ser  Phe Ala Lys 
    1145                 1150                 1155             


Asn Cys  His Glu Asp Thr Cys  Asn Cys Asn Leu Gly  Gly Asp Cys 
    1160                 1165                 1170             


Glu Cys  Leu Cys Thr Ser Ile  Ala Ala Tyr Ala Tyr  Lys Cys Cys 
    1175                 1180                 1185             


Gln Glu  Gly Ile Ser Ile His  Trp Arg Ser Ser Thr  Val Cys Ser 
    1190                 1195                 1200             


Leu Asp  Cys Glu Tyr Tyr Asn  Glu Gly Leu Gly Glu  Gly Pro Tyr 
    1205                 1210                 1215             


Met Leu  Ala Ser Tyr Gly Gln  Ser Gly Leu Val Leu  Gly Ala Asn 
    1220                 1225                 1230             


Met Thr  Ser Arg Ser Val Phe  Cys Leu Pro Arg Ser  Ser Val His 
    1235                 1240                 1245             


Thr Ser  Leu Phe Phe Tyr Phe  Met Ile Thr Pro Gly  Leu Phe Lys 
    1250                 1255                 1260             


Glu Lys  Val Ser Ser Leu Ala  Leu Val Ser Leu Glu  Ser Ala Glu 
    1265                 1270                 1275             


Arg Pro  Asn Tyr Phe Leu Tyr  Val His Asp Asn Asp  Thr Leu Ser 
    1280                 1285                 1290             


Leu Glu  Leu Trp Glu Ala Asn  Ser Ala Phe His Arg  Arg Ala Thr 
    1295                 1300                 1305             


Phe Phe  His His Gln Gly Leu  Trp Ile Pro Gly Tyr  Ser Ala Phe 
    1310                 1315                 1320             


Glu Leu  Tyr Ser Lys Lys Gly  Phe Phe Ile Ile Phe  Thr Asp Ser 
    1325                 1330                 1335             


Ser Val  Lys Ala Ser Lys Tyr  Asp Asp Ser Glu Glu  Phe Lys His 
    1340                 1345                 1350             


Ser Ser  Ser Phe Ser Ile Glu  Glu Ile Gln Ala Ala  Val Pro Tyr 
    1355                 1360                 1365             


Arg Lys  Met Cys Glu Trp Arg  Tyr Glu Pro Cys Ala  Thr Pro Cys 
    1370                 1375                 1380             


Phe Lys  Thr Cys Ser Asp Pro  Glu Ala Leu Ala Cys  Lys Phe Leu 
    1385                 1390                 1395             


Pro Pro  Val Glu Gly Cys Leu  Pro Tyr Cys Pro Lys  Asn Met Ile 
    1400                 1405                 1410             


Leu Asp  Glu Val Thr Leu Lys  Cys Val Tyr Pro Arg  Asp Cys Ile 
    1415                 1420                 1425             


Pro Val  Ile Pro Thr Glu Pro  Thr Leu Met Pro Pro  Ala Lys Pro 
    1430                 1435                 1440             


Thr Val  Pro Met Phe Thr Val  Trp Glu Met Ile Thr  Pro Ser Asp 
    1445                 1450                 1455             


Ile Thr  Val Phe Asp Met Leu  Thr Pro Thr Thr Gly  Leu Glu Cys 
    1460                 1465                 1470             


Glu Pro  Gln Lys Phe Asp Pro  Val Tyr Asp Cys Ser  Gln Tyr Ile 
    1475                 1480                 1485             


Cys Leu  Asn Met Glu Trp Gln  Leu Tyr Asn Trp Ser  Leu Asn Cys 
    1490                 1495                 1500             


Pro Lys  Asp Val Glu Met Pro  Asp Cys Gly Phe Arg  Gly Arg Pro 
    1505                 1510                 1515             


Val Gln  Val Asn Ser Asp Ile  Cys Cys Pro Glu Trp  Glu Cys Pro 
    1520                 1525                 1530             


Cys Arg  Cys Ser Met Leu Ser  Glu Leu Ser Ile Ile  Thr Phe Asp 
    1535                 1540                 1545             


Gly Asn  Asn Ala Ala Leu Tyr  Ser Met Ala Ser Tyr  Ile Leu Val 
    1550                 1555                 1560             


Arg Ile  Pro Gly Glu Ile Ile  Val Ala His Ile Glu  Lys Cys Ser 
    1565                 1570                 1575             


Met Asn  Gln Asn Gly Asn Ser  Leu Lys Lys Leu Ala  Pro Ser Gly 
    1580                 1585                 1590             


Arg Ile  Ser Gly Leu Cys Phe  Lys Lys Leu Asn Val  Thr Thr Pro 
    1595                 1600                 1605             


Ile His  Lys Ile Ile Val Asn  Arg Leu Ala Arg Lys  Val Glu Val 
    1610                 1615                 1620             


Asp Ser  Ile Val Val Pro Leu  Pro Phe Ser Ser Gln  Glu Leu Ser 
    1625                 1630                 1635             


Ile Glu  Asp Ser Gly Ser Met  Tyr Val Ile Thr Thr  Pro Ala Gly 
    1640                 1645                 1650             


Leu Ile  Ile Lys Trp Ser His  Leu Thr Gly Ile Ile  Asp Ile His 
    1655                 1660                 1665             


Phe Gly  Phe Arg Phe Asn Leu  Ser Ser Tyr Thr Glu  Gly Leu Cys 
    1670                 1675                 1680             


Gly Ile  Cys Asn Glu Asp Pro  Asp Asp Asp Leu Arg  Met Gln Asn 
    1685                 1690                 1695             


Gly Thr  Ile Ile Thr Asn Met  Glu Asp Ile Gly Leu  Phe Ile Glu 
    1700                 1705                 1710             


Ser Trp  Glu Ile Glu Lys Ser  Phe Glu Val Thr Met  Arg Arg Pro 
    1715                 1720                 1725             


Val Arg  Asn Cys Thr Glu His  Asp Cys Ser Gln Cys  Ile Asp Leu 
    1730                 1735                 1740             


Leu Asn  Arg Arg Ile Phe Ile  Pro Cys His Asp Lys  Val Ser Pro 
    1745                 1750                 1755             


Glu Asp  Phe Cys Glu Lys Met  Trp Ile Asn Tyr Thr  Tyr Phe Trp 
    1760                 1765                 1770             


Asn Tyr  Glu Cys Asp Ala Leu  Ser Ala Tyr Val Ala  Leu Cys Asn 
    1775                 1780                 1785             


Lys Phe  Asp Ile Cys Ile Gln  Trp Arg Thr Pro Asp  Tyr Cys Ser 
    1790                 1795                 1800             


Leu Ser  Cys Pro Glu Gly Lys  Glu Tyr Gln Pro Cys  Val Arg Pro 
    1805                 1810                 1815             


Cys Glu  Ala Arg Thr Cys Leu  Asn Gln Trp Phe Tyr  Gly His Thr 
    1820                 1825                 1830             


Ser Cys  Leu Asn Leu Arg Glu  Asp Cys Val Cys Lys  Val Gly Thr 
    1835                 1840                 1845             


Ile Leu  His Arg Pro His Ser  Ala Gln Cys Ile Pro  Glu Lys Glu 
    1850                 1855                 1860             


Cys Ala  Cys Thr Asp Ser Glu  Asp Gln Pro Arg Thr  Ala Gly Glu 
    1865                 1870                 1875             


Ile Trp  Asn Gly Gly Ile Asp  Glu Cys Thr Leu Tyr  Lys Cys Leu 
    1880                 1885                 1890             


Glu Asn  Gly Ser Ile Ile Pro  Ile Glu Pro Asp Cys  Asp Glu Glu 
    1895                 1900                 1905             


Pro Thr  Pro Val Cys Glu Arg  Glu Ala Glu Val Val  Met Gly Ile 
    1910                 1915                 1920             


Ile Asp  Lys Trp Thr Cys Cys  Ser Lys Glu Val Cys  Gly Cys Asp 
    1925                 1930                 1935             


Thr Thr  Leu Cys Glu Thr Ser  Ile Pro Thr Cys Thr  Asn Ser Gln 
    1940                 1945                 1950             


Lys Leu  Ile Val Gly His Ser  Pro Leu Ser Cys Cys  Pro Gln Tyr 
    1955                 1960                 1965             


Lys Cys  Glu Cys Asp Pro Leu  Lys Cys Pro Ser Ile  Ser Thr Pro 
    1970                 1975                 1980             


Glu Cys  Arg Glu Asp Gln Phe  Met Ile Gln Val Arg  Gln Glu Glu 
    1985                 1990                 1995             


Pro Cys  Cys Phe Ser Pro Phe  Cys Val Cys Glu Ser  Cys Thr Lys 
    2000                 2005                 2010             


Pro Val  Pro Leu Cys His Asp  Gly Glu Phe Leu Thr  Val Asp Leu 
    2015                 2020                 2025             


Asn Ser  Thr His Phe Cys Cys  Pro Gln Tyr Tyr Cys  Val Cys Glu 
    2030                 2035                 2040             


Pro Asn  Leu Cys Pro Met Pro  Leu Leu Asn Cys Ala  Glu Asp Met 
    2045                 2050                 2055             


Asn Leu  Val Lys Glu Asn Val  Ser Gly Gln Cys Cys  Pro Thr Trp 
    2060                 2065                 2070             


His Cys  Glu Cys Asn Cys Glu  Asn Leu Ile Met Pro  Thr Cys Glu 
    2075                 2080                 2085             


Val Gly  Glu Phe Thr Ala Ile  Asp His Asn Phe Gln  Ser Asp Cys 
    2090                 2095                 2100             


Gly Cys  Ile Gln Tyr Leu Cys  Glu Lys Asp Asp Val  Cys Val Phe 
    2105                 2110                 2115             


Gln Glu  Val Ser Val Leu Asn  Pro Gly Gln Ser Met  Ile Lys Tyr 
    2120                 2125                 2130             


Leu Glu  Glu Asp Phe Cys Tyr  Ala Ile Glu Cys Leu  Glu Glu Lys 
    2135                 2140                 2145             


Asp Asn  His Thr Gly Phe His  Thr Leu Asn Phe Thr  Leu Val Asn 
    2150                 2155                 2160             


Cys Ser  Lys Lys Cys Asp Val  His Gln Val Tyr Thr  Pro Ser Pro 
    2165                 2170                 2175             


Ser Asp  Tyr Gly Cys Cys Gly  Thr Cys Lys Asn Val  Ser Cys Lys 
    2180                 2185                 2190             


Phe His  Met Glu Asn Gly Thr  Ser Val Val Tyr Ala  Val Gly Ser 
    2195                 2200                 2205             


Thr Trp  His Tyr Asn Cys Thr  Thr Tyr Glu Cys Val  Lys Thr Asp 
    2210                 2215                 2220             


Glu Gly  Ala Ile Ile Leu Asn  Tyr Thr Met Val Cys  Pro Pro Phe 
    2225                 2230                 2235             


Asn Glu  Thr Glu Cys Lys Met  Asn Glu Gly Ile Val  Lys Leu Tyr 
    2240                 2245                 2250             


Asn Glu  Gly Cys Cys Lys Ile  Cys Lys Arg Glu Glu  Arg Ile Cys 
    2255                 2260                 2265             


Gln Lys  Val Ile Ile Lys Ser  Val Ile Arg Lys Gln  Asp Cys Met 
    2270                 2275                 2280             


Ser Gln  Ser Pro Ile Asn Val  Ala Ser Cys Asp Gly  Lys Cys Pro 
    2285                 2290                 2295             


Ser Ala  Thr Ile Tyr Asn Ile  Asn Ile Glu Ser His  Leu Arg Phe 
    2300                 2305                 2310             


Cys Lys  Cys Cys Arg Glu Asn  Gly Val Arg Asn Leu  Ser Val Pro 
    2315                 2320                 2325             


Leu Tyr  Cys Ser Gly Asn Gly  Thr Glu Ile Met Tyr  Thr Leu Gln 
    2330                 2335                 2340             


Glu Pro  Ile Asp Cys Thr Cys  Gln Trp Asn 
    2345                 2350             


<210>  9875
<211>  2308
<212>  PRT
<213>  Homo Sapiens

<400>  9875

Met Asn Ile Val Arg Lys Leu Asn Leu Met Ile Pro Trp Ser Ile Phe 
1               5                   10                  15      


Leu Leu His Val Leu Leu Phe Ser Leu Gln Glu Tyr Ile Cys Ala Ser 
            20                  25                  30          


Ser Ile Leu Met Gly Thr Ser Lys Asn Gly Phe Asn Glu Asn Arg Gln 
        35                  40                  45              


Lys Arg Ala Leu Leu Ala Ala Gln Phe Glu Ala Thr Ser Pro Arg Tyr 
    50                  55                  60                  


Phe Phe His Asp Ala Ile Asn Trp Gly Glu Ser Lys Ile Lys Gly Ser 
65                  70                  75                  80  


Cys Pro Tyr Glu Cys Leu Asn Gly Ala Phe Cys Ser Lys Thr Gly Thr 
                85                  90                  95      


Cys Asp Cys Gln Ile Phe Gln Ala Leu Gly Thr Arg Cys Gln Ile Ile 
            100                 105                 110         


Pro Asn Met Gly Asn Gly Arg Asp Gly Ile Cys Lys Thr Trp Gly Gln 
        115                 120                 125             


Tyr His Phe Glu Thr Phe Asp Gly Ile Tyr Tyr Tyr Phe Pro Gly Asn 
    130                 135                 140                 


Cys Ser Tyr Ile Phe Ala Lys Asp Cys Gly Asp Leu Glu Pro Arg Tyr 
145                 150                 155                 160 


Thr Val Trp Val His Asn Ser Pro Lys Cys Leu Gly Ser Val Tyr Ser 
                165                 170                 175     


Cys Tyr Arg Ser Ile Ser Leu Phe Phe Ser Asn Gln Glu Glu Ile Arg 
            180                 185                 190         


Ile Tyr Gly His Glu Ile Lys Lys Asn Gly Ile Ser Leu Thr Leu Pro 
        195                 200                 205             


Gln Thr Ile Gly Gln Ile Phe Ile Glu Lys Leu Ala Asp Tyr Ile Leu 
    210                 215                 220                 


Val Lys Thr Thr Phe Gly Phe Ser Leu Ala Trp Asp Gly Ile Ser Gly 
225                 230                 235                 240 


Ile Tyr Leu Lys Leu Ser Glu Asp His Lys Gly Lys Ser Cys Gly Leu 
                245                 250                 255     


Cys Gly Asn Tyr Asn Asp Ile Gln Ser Asp Asp Phe Ile Ile Leu Gln 
            260                 265                 270         


Glu Asp Tyr Thr Glu Asp Ile Ala Met Phe Ala Asn Ser Trp Ser Val 
        275                 280                 285             


Gln Thr Pro Asp Asp Thr Lys Cys Val Leu Thr Pro Ser Asp Phe Pro 
    290                 295                 300                 


Asn Pro Cys Ser Ser Gly Met Pro Ala Phe Glu Ala Ile Phe Phe Lys 
305                 310                 315                 320 


Cys Gln Ile Leu Leu Gln Phe Pro Phe Leu Ser Cys His Glu Tyr Ile 
                325                 330                 335     


Asp Pro Tyr Leu Tyr Ile Ala Ser Cys Val Asn Asp Leu Cys Lys Thr 
            340                 345                 350         


Asp Asp Asp Glu Thr Tyr Cys Arg Ala Ala Thr Glu Tyr Ala Arg Ala 
        355                 360                 365             


Cys Ser His Ala Gly Tyr Pro Ile Gln Asp Trp Arg Asp Asp Phe Pro 
    370                 375                 380                 


Ala Cys Thr Asp Lys Cys Asp Asp Ser Phe Val His Arg Asp Cys Ile 
385                 390                 395                 400 


Ser Cys Cys Pro Pro Thr Cys Thr Phe Glu Lys Gln Cys Leu Gly Ser 
                405                 410                 415     


Asn Leu His Cys Leu Asp Gly Cys Tyr Cys Pro Asp Gly Leu Val Met 
            420                 425                 430         


Asp Asn Gly Thr Cys Ile Ser Leu Glu Asn Cys Pro Cys Gly Phe His 
        435                 440                 445             


Gly Leu Ala Tyr Ser Val Gly Ser Lys Ile Glu Gln Glu Cys Thr Glu 
    450                 455                 460                 


Cys Val Cys Val Gly Gly Val Trp Asn Cys Thr Glu Gln Asp Cys Pro 
465                 470                 475                 480 


Val Gln Cys Ser Val Val Gly Asp Ser His Phe Thr Thr Phe Asp Gly 
                485                 490                 495     


Arg His Tyr Ser Phe Ile Gly Met Cys Gln Tyr Ile Leu Val Lys Gly 
            500                 505                 510         


Thr Gly Lys Asp Lys Phe Thr Ile Thr Leu Gln Lys Ala Pro Cys Glu 
        515                 520                 525             


Gln Asn Leu Gly Leu Val Cys Leu Gln Ser Ile Thr Leu Ile Leu Glu 
    530                 535                 540                 


Asp Asp Phe Asn Lys Gln Val Thr Leu Gly Arg Gly Gly Gln Ile Leu 
545                 550                 555                 560 


Thr Ser Pro Asn Gln Gly Phe Asn Leu Asn Gly Ile Val Glu Ile Gln 
                565                 570                 575     


Thr Leu Ser Ser Leu Phe Ile Leu Leu Lys Thr Thr Phe Gly Leu Lys 
            580                 585                 590         


Ile Leu Phe Ala Ile Asp Gly Glu Arg Ile Tyr Ile Gln Leu Thr Ser 
        595                 600                 605             


Ala Trp Lys Arg Arg Thr Leu Gly Leu Cys Gly Thr Phe Asn Gly Asn 
    610                 615                 620                 


Ile Arg Asp Asp Phe Leu Ser Pro Ser Gly Met Ile Glu Gly Thr Pro 
625                 630                 635                 640 


Gln Leu His Ala Asn Ala Trp Arg Val Ser Ser Thr Cys Phe Ala Pro 
                645                 650                 655     


Val His Val Pro Val Val Asp Pro Cys Asn Ile Asn Gln Gln Asn Ile 
            660                 665                 670         


Gly Tyr Ala Ala His Cys Asp Val Ile His Gln Glu Leu Phe Ala Pro 
        675                 680                 685             


Cys His Ile Tyr Ile Ser Pro Gly Leu Tyr Tyr Gln Leu Cys Arg His 
    690                 695                 700                 


Asp Ala Cys Lys Cys Gly Ser Ser Cys Leu Cys Asn Ala Leu Ala His 
705                 710                 715                 720 


Tyr Ala Tyr Leu Cys Gly Gln His Gly Val Pro Ile Asp Phe Arg Thr 
                725                 730                 735     


Gln Ile Ser Phe Cys Ala Val Val Cys Gln Lys Gly Met Leu Tyr His 
            740                 745                 750         


His Cys Ser Ser Phe Cys Leu His Ser Cys Ile Ser Leu Ser Ser Pro 
        755                 760                 765             


Glu Gln Cys Ser Asp Asp Cys Ala Glu Gly Cys Asn Cys Pro Glu Gly 
    770                 775                 780                 


Lys Phe Tyr Glu Asp Thr Leu Asn Phe Cys Val Pro Ile Phe His Cys 
785                 790                 795                 800 


Arg Cys His Tyr Arg Gly Ser Val Tyr Gln Pro Gly Glu Leu Ile Pro 
                805                 810                 815     


Thr Pro Ser Gly Leu Cys Gln Cys Ser Asn Gly Thr Val Lys Cys Asp 
            820                 825                 830         


Glu Leu Ala Thr Pro Ser Ala Val His Ile Cys Pro Glu Gly Lys Glu 
        835                 840                 845             


Tyr Phe Asp Cys Arg Phe Pro Asp Pro Glu Leu Pro Ala Gly Gly Val 
    850                 855                 860                 


Asn Cys Glu Thr Thr Cys Ala Asn Leu Ala Met Asn Phe Thr Cys Thr 
865                 870                 875                 880 


Pro Ser Ser Pro Cys Ile Ser Gly Cys Val Cys Ala Pro Gly Met Ala 
                885                 890                 895     


Glu His Arg Gly Lys Cys Tyr Val Pro Glu Ser Cys Pro Cys Ile Trp 
            900                 905                 910         


Lys Asp Trp Glu Tyr Leu Ser Gly Glu Val Ile Ala Thr Pro Cys Tyr 
        915                 920                 925             


Thr Cys Val Cys Arg Arg Gly Met Phe Asn Cys Thr Tyr Tyr Pro Cys 
    930                 935                 940                 


Pro Ala Val Cys Thr Ile Tyr Gly Asp Arg His Tyr Tyr Ser Phe Asp 
945                 950                 955                 960 


Gly Leu Glu Tyr Asp Tyr Ile Ser Asp Cys Gln Val Phe Leu Ile Lys 
                965                 970                 975     


Lys Gln Ser Gly Phe Phe Leu Glu Asn Lys Ser Thr Tyr Gln Leu Trp 
            980                 985                 990         


Lys Ala Gly Tyr Tyr Ile Val Val  Tyr Phe Pro Glu Lys  Asp Ile Thr 
        995                 1000                 1005             


Ile Leu  Trp Asp Arg Lys Thr  Thr Ile His Ile Lys  Val Gly Pro 
    1010                 1015                 1020             


Gln Trp  Lys Asn Lys Leu Ser  Gly Leu Cys Gly Asn  Phe Asp Lys 
    1025                 1030                 1035             


Cys Thr  Ser Asn Asp Met Thr  Thr Ser Asn Asn Leu  Glu Val Arg 
    1040                 1045                 1050             


Asn Ala  Arg Val Phe Gly Asp  Ser Trp Ala Leu Gly  Gln Cys Glu 
    1055                 1060                 1065             


Ser Pro  Asp Glu Thr Ile Lys  Pro Cys Glu Ala His  Gln Asn Lys 
    1070                 1075                 1080             


Phe Pro  Tyr Ala Lys Lys Glu  Cys Ser Ile Leu Tyr  Ser Asp Ile 
    1085                 1090                 1095             


Phe Ala  Ser Cys Arg Asn Val  Ile Asp Val Thr Ser  Phe Ala Lys 
    1100                 1105                 1110             


Asn Cys  His Glu Asp Thr Cys  Asn Cys Asn Leu Gly  Gly Asp Cys 
    1115                 1120                 1125             


Glu Cys  Leu Cys Thr Ser Ile  Ala Ala Tyr Ala Tyr  Lys Cys Cys 
    1130                 1135                 1140             


Gln Glu  Gly Ile Ser Ile His  Trp Arg Ser Ser Thr  Val Cys Ser 
    1145                 1150                 1155             


Leu Asp  Cys Glu Tyr Tyr Asn  Glu Gly Leu Gly Glu  Gly Pro Tyr 
    1160                 1165                 1170             


Met Leu  Ala Ser Tyr Gly Gln  Ser Gly Leu Val Leu  Gly Ala Asn 
    1175                 1180                 1185             


Met Thr  Ser Arg Ser Val Phe  Cys Leu Pro Arg Ser  Ser Val His 
    1190                 1195                 1200             


Thr Ser  Leu Phe Phe Tyr Phe  Met Ile Thr Pro Gly  Leu Phe Lys 
    1205                 1210                 1215             


Glu Lys  Val Ser Ser Leu Ala  Leu Val Ser Leu Glu  Ser Ala Glu 
    1220                 1225                 1230             


Arg Pro  Asn Tyr Phe Leu Tyr  Val His Asp Asn Asp  Thr Leu Ser 
    1235                 1240                 1245             


Leu Glu  Leu Trp Glu Ala Asn  Ser Ala Phe His Arg  Arg Ala Thr 
    1250                 1255                 1260             


Phe Phe  His His Gln Gly Leu  Trp Ile Pro Gly Tyr  Ser Ala Phe 
    1265                 1270                 1275             


Glu Leu  Tyr Ser Lys Lys Gly  Phe Phe Ile Ile Phe  Thr Asp Ser 
    1280                 1285                 1290             


Ser Val  Lys Ala Ser Lys Tyr  Asp Asp Ser Glu Glu  Phe Lys His 
    1295                 1300                 1305             


Ser Ser  Ser Phe Ser Ile Glu  Glu Ile Gln Ala Ala  Val Pro Tyr 
    1310                 1315                 1320             


Arg Lys  Met Cys Glu Trp Arg  Tyr Glu Pro Cys Ala  Thr Pro Cys 
    1325                 1330                 1335             


Phe Lys  Thr Cys Ser Asp Pro  Glu Ala Leu Ala Cys  Lys Phe Leu 
    1340                 1345                 1350             


Pro Pro  Val Glu Gly Cys Leu  Pro Tyr Cys Pro Lys  Asn Met Ile 
    1355                 1360                 1365             


Leu Asp  Glu Val Thr Leu Lys  Cys Val Tyr Pro Arg  Asp Cys Ile 
    1370                 1375                 1380             


Pro Val  Ile Pro Thr Glu Pro  Thr Leu Met Pro Pro  Ala Lys Pro 
    1385                 1390                 1395             


Thr Val  Pro Met Phe Thr Val  Trp Glu Met Ile Thr  Pro Ser Asp 
    1400                 1405                 1410             


Ile Thr  Val Phe Asp Met Leu  Thr Pro Thr Thr Gly  Leu Glu Cys 
    1415                 1420                 1425             


Glu Pro  Gln Lys Phe Asp Pro  Val Tyr Asp Cys Ser  Gln Tyr Ile 
    1430                 1435                 1440             


Cys Leu  Asn Met Glu Trp Gln  Leu Tyr Asn Trp Ser  Leu Asn Cys 
    1445                 1450                 1455             


Pro Lys  Asp Val Glu Met Pro  Asp Cys Gly Phe Arg  Gly Arg Pro 
    1460                 1465                 1470             


Val Gln  Val Asn Ser Asp Ile  Cys Cys Pro Glu Trp  Glu Cys Pro 
    1475                 1480                 1485             


Cys Arg  Cys Ser Met Leu Ser  Glu Leu Ser Ile Ile  Thr Phe Asp 
    1490                 1495                 1500             


Gly Asn  Asn Ala Ala Leu Tyr  Ser Met Ala Ser Tyr  Ile Leu Val 
    1505                 1510                 1515             


Arg Ile  Pro Gly Glu Ile Ile  Val Ala His Ile Glu  Lys Cys Ser 
    1520                 1525                 1530             


Met Asn  Gln Asn Gly Asn Ser  Leu Lys Lys Leu Ala  Pro Ser Gly 
    1535                 1540                 1545             


Arg Ile  Ser Gly Leu Cys Phe  Lys Lys Leu Asn Val  Thr Thr Pro 
    1550                 1555                 1560             


Ile His  Lys Ile Ile Val Asn  Arg Leu Ala Arg Lys  Val Glu Val 
    1565                 1570                 1575             


Asp Ser  Ile Val Val Pro Leu  Pro Phe Ser Ser Gln  Glu Leu Ser 
    1580                 1585                 1590             


Ile Glu  Asp Ser Gly Ser Met  Tyr Val Ile Thr Thr  Pro Ala Gly 
    1595                 1600                 1605             


Leu Ile  Ile Lys Trp Ser His  Leu Thr Gly Ile Ile  Asp Ile His 
    1610                 1615                 1620             


Phe Gly  Phe Arg Phe Asn Leu  Ser Ser Tyr Thr Glu  Gly Leu Cys 
    1625                 1630                 1635             


Gly Ile  Cys Asn Glu Asp Pro  Asp Asp Asp Leu Arg  Met Gln Asn 
    1640                 1645                 1650             


Gly Thr  Ile Ile Thr Asn Met  Glu Asp Ile Gly Leu  Phe Ile Glu 
    1655                 1660                 1665             


Ser Trp  Glu Ile Glu Lys Ser  Phe Glu Val Thr Met  Arg Arg Pro 
    1670                 1675                 1680             


Val Arg  Asn Cys Thr Glu His  Asp Cys Ser Gln Cys  Ile Asp Leu 
    1685                 1690                 1695             


Leu Asn  Arg Arg Ile Phe Ile  Pro Cys His Asp Lys  Val Ser Pro 
    1700                 1705                 1710             


Glu Asp  Phe Cys Glu Lys Met  Trp Ile Asn Tyr Thr  Tyr Phe Trp 
    1715                 1720                 1725             


Asn Tyr  Glu Cys Asp Ala Leu  Ser Ala Tyr Val Ala  Leu Cys Asn 
    1730                 1735                 1740             


Lys Phe  Asp Ile Cys Ile Gln  Trp Arg Thr Pro Asp  Tyr Cys Ser 
    1745                 1750                 1755             


Leu Ser  Cys Pro Glu Gly Lys  Glu Tyr Gln Pro Cys  Val Arg Pro 
    1760                 1765                 1770             


Cys Glu  Ala Arg Thr Cys Leu  Asn Gln Trp Phe Tyr  Gly His Thr 
    1775                 1780                 1785             


Ser Cys  Leu Asn Leu Arg Glu  Asp Cys Val Cys Lys  Val Gly Thr 
    1790                 1795                 1800             


Ile Leu  His Arg Pro His Ser  Ala Gln Cys Ile Pro  Glu Lys Glu 
    1805                 1810                 1815             


Cys Ala  Cys Thr Asp Ser Glu  Asp Gln Pro Arg Thr  Ala Gly Glu 
    1820                 1825                 1830             


Ile Trp  Asn Gly Gly Ile Asp  Glu Cys Thr Leu Tyr  Lys Cys Leu 
    1835                 1840                 1845             


Glu Asn  Gly Ser Ile Ile Pro  Ile Glu Pro Asp Cys  Asp Glu Glu 
    1850                 1855                 1860             


Pro Thr  Pro Val Cys Glu Arg  Glu Ala Glu Val Val  Met Gly Ile 
    1865                 1870                 1875             


Ile Asp  Lys Trp Thr Cys Cys  Ser Lys Glu Val Cys  Gly Cys Asp 
    1880                 1885                 1890             


Thr Thr  Leu Cys Glu Thr Ser  Ile Pro Thr Cys Thr  Asn Ser Gln 
    1895                 1900                 1905             


Lys Leu  Ile Val Gly His Ser  Pro Leu Ser Cys Cys  Pro Gln Tyr 
    1910                 1915                 1920             


Lys Cys  Glu Cys Asp Pro Leu  Lys Cys Pro Ser Ile  Ser Thr Pro 
    1925                 1930                 1935             


Glu Cys  Arg Glu Asp Gln Phe  Met Ile Gln Val Arg  Gln Glu Glu 
    1940                 1945                 1950             


Pro Cys  Cys Phe Ser Pro Phe  Cys Val Cys Glu Ser  Cys Thr Lys 
    1955                 1960                 1965             


Pro Val  Pro Leu Cys His Asp  Gly Glu Phe Leu Thr  Val Asp Leu 
    1970                 1975                 1980             


Asn Ser  Thr His Phe Cys Cys  Pro Gln Tyr Tyr Cys  Val Cys Glu 
    1985                 1990                 1995             


Pro Asn  Leu Cys Pro Met Pro  Leu Leu Asn Cys Ala  Glu Asp Met 
    2000                 2005                 2010             


Asn Leu  Val Lys Glu Asn Val  Ser Gly Gln Cys Cys  Pro Thr Trp 
    2015                 2020                 2025             


His Cys  Glu Cys Asn Cys Glu  Asn Leu Ile Met Pro  Thr Cys Glu 
    2030                 2035                 2040             


Val Gly  Glu Phe Thr Ala Ile  Asp His Asn Phe Gln  Ser Asp Cys 
    2045                 2050                 2055             


Gly Cys  Ile Gln Tyr Leu Cys  Glu Lys Asp Asp Val  Cys Val Phe 
    2060                 2065                 2070             


Gln Glu  Val Ser Val Leu Asn  Pro Gly Gln Ser Met  Ile Lys Tyr 
    2075                 2080                 2085             


Leu Glu  Glu Asp Phe Cys Tyr  Ala Ile Glu Cys Leu  Glu Glu Lys 
    2090                 2095                 2100             


Asp Asn  His Thr Gly Phe His  Thr Leu Asn Phe Thr  Leu Val Asn 
    2105                 2110                 2115             


Cys Ser  Lys Lys Cys Asp Val  His Gln Val Tyr Thr  Pro Ser Pro 
    2120                 2125                 2130             


Ser Asp  Tyr Gly Cys Cys Gly  Thr Cys Lys Asn Val  Ser Cys Lys 
    2135                 2140                 2145             


Phe His  Met Glu Asn Gly Thr  Ser Val Val Tyr Ala  Val Gly Ser 
    2150                 2155                 2160             


Thr Trp  His Tyr Asn Cys Thr  Thr Tyr Glu Cys Val  Lys Thr Asp 
    2165                 2170                 2175             


Glu Gly  Ala Ile Ile Leu Asn  Tyr Thr Met Val Cys  Pro Pro Phe 
    2180                 2185                 2190             


Asn Glu  Thr Glu Cys Lys Met  Asn Glu Gly Ile Val  Lys Leu Tyr 
    2195                 2200                 2205             


Asn Glu  Gly Cys Cys Lys Ile  Cys Lys Arg Glu Glu  Arg Ile Cys 
    2210                 2215                 2220             


Gln Lys  Val Ile Ile Lys Ser  Val Ile Arg Lys Gln  Asp Cys Met 
    2225                 2230                 2235             


Ser Gln  Ser Pro Ile Asn Val  Ala Ser Cys Asp Gly  Lys Cys Pro 
    2240                 2245                 2250             


Ser Ala  Thr Ile Tyr Asn Ile  Asn Ile Glu Ser His  Leu Arg Phe 
    2255                 2260                 2265             


Cys Lys  Cys Cys Arg Glu Asn  Gly Val Arg Asn Leu  Ser Val Pro 
    2270                 2275                 2280             


Leu Tyr  Cys Ser Gly Asn Gly  Thr Glu Ile Met Tyr  Thr Leu Gln 
    2285                 2290                 2295             


Glu Pro  Ile Asp Cys Thr Cys  Gln Trp Asn 
    2300                 2305             


<210>  9876
<211>  101
<212>  PRT
<213>  Homo Sapiens

<400>  9876

Asn Phe Thr Leu Val Asn Cys Ser Lys Lys Cys Asp Val His Gln Val 
1               5                   10                  15      


Tyr Thr Pro Ser Pro Ser Asp Tyr Gly Cys Cys Gly Thr Cys Lys Asn 
            20                  25                  30          


Val Ser Cys Lys Phe His Met Glu Asn Gly Thr Ser Val Val Tyr Ala 
        35                  40                  45              


Val Gly Ser Thr Trp His Tyr Asn Cys Thr Thr Tyr Glu Cys Val Lys 
    50                  55                  60                  


Thr Asp Glu Gly Ala Ile Ile Leu Asn Tyr Thr Met Val Cys Pro Pro 
65                  70                  75                  80  


Phe Asn Glu Thr Glu Cys Lys Met Val Cys Thr Leu Leu Tyr Leu Arg 
                85                  90                  95      


Lys Phe Ile Ile Ile 
            100     


<210>  9877
<211>  752
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9877

Xaa Glu Ile Ile Val Ala His Ile Glu Lys Cys Ser Met Asn Gln Asn 
1               5                   10                  15      


Gly Asn Ser Leu Lys Lys Leu Ala Pro Ser Gly Arg Ile Ser Gly Leu 
            20                  25                  30          


Cys Phe Lys Lys Leu Asn Val Thr Thr Pro Ile His Lys Ile Ile Val 
        35                  40                  45              


Asn Arg Leu Ala Arg Lys Val Glu Val Asp Ser Ile Val Val Pro Leu 
    50                  55                  60                  


Pro Phe Ser Ser Gln Glu Leu Ser Ile Glu Asp Ser Gly Ser Met Tyr 
65                  70                  75                  80  


Val Ile Thr Thr Pro Ala Gly Leu Ile Ile Lys Trp Ser His Leu Thr 
                85                  90                  95      


Gly Ile Ile Asp Ile His Phe Gly Phe Arg Phe Asn Leu Ser Ser Tyr 
            100                 105                 110         


Thr Glu Gly Leu Cys Gly Ile Cys Asn Glu Asp Pro Asp Asp Asp Leu 
        115                 120                 125             


Arg Met Gln Asn Gly Thr Ile Ile Thr Asn Met Glu Asp Ile Gly Leu 
    130                 135                 140                 


Phe Ile Glu Ser Trp Glu Ile Glu Lys Ser Phe Glu Val Thr Met Arg 
145                 150                 155                 160 


Arg Pro Val Arg Asn Cys Thr Glu His Asp Cys Ser Gln Cys Ile Asp 
                165                 170                 175     


Leu Leu Asn Arg Arg Ile Phe Ile Pro Cys His Asp Lys Val Ser Pro 
            180                 185                 190         


Glu Asp Phe Cys Glu Lys Met Trp Ile Asn Tyr Thr Tyr Phe Trp Asn 
        195                 200                 205             


Tyr Glu Cys Asp Ala Leu Ser Ala Tyr Val Ala Leu Cys Asn Lys Phe 
    210                 215                 220                 


Asp Ile Cys Ile Gln Trp Arg Thr Pro Asp Tyr Cys Ser Leu Ser Cys 
225                 230                 235                 240 


Pro Glu Gly Lys Glu Tyr Gln Pro Cys Val Arg Pro Cys Glu Ala Arg 
                245                 250                 255     


Thr Cys Leu Asn Gln Trp Phe Tyr Gly His Thr Ser Cys Leu Asn Leu 
            260                 265                 270         


Arg Glu Asp Cys Val Cys Lys Val Gly Thr Ile Leu His Arg Pro His 
        275                 280                 285             


Ser Ala Gln Cys Ile Pro Glu Lys Glu Cys Ala Cys Thr Asp Ser Glu 
    290                 295                 300                 


Asp Gln Pro Arg Thr Ala Gly Glu Ile Trp Asn Gly Gly Ile Asp Glu 
305                 310                 315                 320 


Cys Thr Leu Tyr Lys Cys Leu Glu Asn Gly Ser Ile Ile Pro Ile Glu 
                325                 330                 335     


Pro Asp Cys Asp Glu Glu Pro Thr Pro Val Cys Glu Arg Glu Ala Glu 
            340                 345                 350         


Val Val Met Gly Ile Ile Asp Lys Trp Thr Cys Cys Ser Lys Glu Val 
        355                 360                 365             


Cys Gly Cys Asp Thr Thr Leu Cys Glu Thr Ser Ile Pro Thr Cys Thr 
    370                 375                 380                 


Asn Ser Gln Lys Leu Ile Val Gly His Ser Pro Leu Ser Cys Cys Pro 
385                 390                 395                 400 


Gln Tyr Lys Cys Glu Cys Asp Pro Leu Lys Cys Pro Ser Ile Ser Thr 
                405                 410                 415     


Pro Glu Cys Arg Glu Asp Gln Phe Met Ile Gln Val Arg Gln Glu Glu 
            420                 425                 430         


Pro Cys Cys Phe Ser Pro Phe Cys Val Cys Glu Ser Cys Thr Lys Pro 
        435                 440                 445             


Val Pro Leu Cys His Asp Gly Glu Phe Leu Thr Val Asp Leu Asn Ser 
    450                 455                 460                 


Thr His Phe Cys Cys Pro Gln Tyr Tyr Cys Val Cys Glu Pro Asn Leu 
465                 470                 475                 480 


Cys Pro Met Pro Leu Leu Asn Cys Ala Glu Asp Met Asn Leu Val Lys 
                485                 490                 495     


Glu Asn Val Ser Gly Gln Cys Cys Pro Thr Trp His Cys Glu Lys Asp 
            500                 505                 510         


Asp Val Cys Val Phe Gln Glu Val Ser Val Leu Asn Pro Gly Gln Ser 
        515                 520                 525             


Met Ile Lys Tyr Leu Glu Glu Asp Phe Cys Tyr Ala Ile Glu Cys Leu 
    530                 535                 540                 


Glu Glu Lys Asp Asn His Thr Gly Phe His Thr Leu Asn Phe Thr Leu 
545                 550                 555                 560 


Val Asn Cys Ser Lys Lys Cys Asp Val His Gln Val Tyr Thr Pro Ser 
                565                 570                 575     


Pro Ser Asp Tyr Gly Cys Cys Gly Thr Cys Lys Asn Val Ser Cys Lys 
            580                 585                 590         


Phe His Met Glu Asn Gly Thr Ser Val Val Tyr Ala Val Gly Ser Thr 
        595                 600                 605             


Trp His Tyr Asn Cys Thr Thr Tyr Glu Cys Val Lys Thr Asp Glu Gly 
    610                 615                 620                 


Ala Ile Ile Leu Asn Tyr Thr Met Val Cys Pro Pro Phe Asn Glu Thr 
625                 630                 635                 640 


Glu Cys Lys Met Asn Glu Gly Ile Val Lys Leu Tyr Asn Glu Gly Cys 
                645                 650                 655     


Cys Lys Ile Cys Lys Arg Glu Glu Arg Ile Cys Gln Lys Val Ile Ile 
            660                 665                 670         


Lys Ser Val Ile Arg Lys Gln Asp Cys Met Ser Gln Ser Pro Ile Asn 
        675                 680                 685             


Val Ala Ser Cys Asp Gly Lys Cys Pro Ser Ala Thr Ile Tyr Asn Ile 
    690                 695                 700                 


Asn Ile Glu Ser His Leu Arg Phe Cys Lys Cys Cys Arg Glu Asn Gly 
705                 710                 715                 720 


Val Arg Asn Leu Ser Val Pro Leu Tyr Cys Ser Gly Asn Gly Thr Glu 
                725                 730                 735     


Ile Met Tyr Thr Leu Gln Glu Pro Ile Asp Cys Thr Cys Gln Trp Asn 
            740                 745                 750         


<210>  9878
<211>  166
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9878

Xaa His Ser Pro Leu Ser Cys Cys Pro Gln Tyr Lys Cys Glu Cys Asp 
1               5                   10                  15      


Pro Leu Lys Cys Pro Ser Ile Ser Thr Pro Glu Cys Arg Glu Asp Gln 
            20                  25                  30          


Phe Met Ile Gln Val Arg Gln Glu Glu Pro Cys Cys Phe Ser Pro Phe 
        35                  40                  45              


Cys Val Cys Glu Ser Cys Thr Lys Pro Val Pro Leu Cys His Asp Gly 
    50                  55                  60                  


Glu Phe Leu Thr Val Asp Leu Asn Ser Thr His Phe Cys Cys Pro Gln 
65                  70                  75                  80  


Tyr Tyr Cys Val Cys Glu Pro Asn Leu Cys Pro Met Pro Leu Leu Asn 
                85                  90                  95      


Cys Ala Glu Asp Met Asn Leu Val Lys Glu Asn Val Ser Gly Gln Cys 
            100                 105                 110         


Cys Pro Thr Trp His Cys Glu Cys Asn Cys Glu Asn Leu Ile Met Pro 
        115                 120                 125             


Thr Cys Glu Val Gln Pro Cys Ala Asp Ala Asp Ile Arg Thr Leu Gly 
    130                 135                 140                 


Cys Leu Gly Arg Ala Asp Gln Glu His Phe His Glu Ala Lys Phe Leu 
145                 150                 155                 160 


Arg Glu Asn Leu Leu Gln 
                165     


<210>  9879
<211>  477
<212>  PRT
<213>  Homo Sapiens

<400>  9879

Met Trp Met Phe Ser Trp Leu Cys Ala Ile Leu Ile Ile Leu Ala Ile 
1               5                   10                  15      


Ala Gly Met Asn Thr Ile Ala Lys Thr Thr Pro His Thr Lys Phe Thr 
            20                  25                  30          


Lys Lys Ser Glu Glu Arg Glu Met Pro Lys Gly Leu Lys Pro Ser Ser 
        35                  40                  45              


Gly Pro Pro Pro Glu Glu Glu Glu Thr Leu Phe Thr Glu Met Ala Glu 
    50                  55                  60                  


Met Ala Glu Pro Ile Thr Lys Pro Ser Ala Leu Asp Ser Val Phe Gly 
65                  70                  75                  80  


Thr Ala Thr Leu Ser Pro Phe Glu Asn Phe Thr Leu Asp Pro Ala Asp 
                85                  90                  95      


Phe Phe Leu Asn Cys Cys Asp Cys Cys Ser Pro Val Pro Gly Gln Lys 
            100                 105                 110         


Gly Glu Pro Gly Glu Thr Gly Gln Pro Gly Pro Lys Gly Glu Ala Gly 
        115                 120                 125             


Asn Leu Gly Ile Pro Gly Pro Pro Gly Val Val Gly Pro Gln Gly Pro 
    130                 135                 140                 


Arg Gly Tyr Lys Gly Glu Lys Gly Leu Lys Gly Glu Arg Gly Asp Gln 
145                 150                 155                 160 


Gly Val Pro Gly Tyr Pro Gly Lys Pro Gly Ala Gln Gly Glu Pro Gly 
                165                 170                 175     


Pro Lys Gly Asp Lys Gly Asn Ile Gly Leu Gly Gly Val Lys Gly Gln 
            180                 185                 190         


Lys Gly Ser Lys Gly Asp Thr Cys Gly Asn Cys Thr Lys Gly Glu Lys 
        195                 200                 205             


Gly Asp Gln Gly Ala Met Gly Ser Pro Gly Leu His Gly Gly Pro Gly 
    210                 215                 220                 


Ala Lys Gly Glu Lys Gly Glu Met Gly Glu Lys Gly Glu Met Gly Asp 
225                 230                 235                 240 


Lys Gly Cys Cys Gly Asp Ser Gly Glu Arg Gly Gly Lys Gly Gln Lys 
                245                 250                 255     


Gly Glu Gly Gly Met Lys Gly Glu Lys Gly Ser Lys Gly Asp Ser Gly 
            260                 265                 270         


Met Glu Gly Lys Ser Gly Arg Asn Gly Leu Pro Gly Ala Lys Gly Asp 
        275                 280                 285             


Pro Gly Ile Lys Gly Glu Lys Gly Glu Leu Gly Pro Pro Gly Leu Leu 
    290                 295                 300                 


Gly Pro Thr Gly Pro Lys Gly Asp Ile Gly Asn Lys Gly Val Arg Gly 
305                 310                 315                 320 


Pro Thr Gly Lys Lys Gly Ser Arg Gly Phe Lys Gly Ser Lys Gly Glu 
                325                 330                 335     


Leu Ala Arg Val Pro Arg Ser Ala Phe Ser Ala Gly Leu Ser Lys Pro 
            340                 345                 350         


Phe Pro Pro Pro Asn Ile Pro Ile Lys Phe Glu Lys Ile Leu Tyr Asn 
        355                 360                 365             


Asp Gln Gly Asn Tyr Ser Pro Val Thr Gly Lys Phe Asn Cys Ser Ile 
    370                 375                 380                 


Pro Gly Thr Tyr Val Phe Ser Tyr His Ile Thr Val Arg Gly Arg Pro 
385                 390                 395                 400 


Ala Arg Ile Ser Leu Val Ala Gln Asn Lys Lys Gln Phe Lys Ser Arg 
                405                 410                 415     


Glu Thr Leu Tyr Gly Gln Glu Ile Asp Gln Ala Ser Leu Leu Val Ile 
            420                 425                 430         


Leu Lys Leu Ser Ala Gly Asp Gln Val Trp Leu Glu Val Ser Lys Asp 
        435                 440                 445             


Trp Asn Gly Val Tyr Val Ser Ala Glu Asp Asp Ser Ile Phe Thr Gly 
    450                 455                 460                 


Phe Leu Leu Tyr Pro Glu Glu Thr Ser Gly Ile Ser Pro 
465                 470                 475         


<210>  9880
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  9880

Met Ala Arg Ile Leu Leu Leu Phe Leu Pro Gly Leu Val Ala Val Cys 
1               5                   10                  15      


Ala Val His Gly Ile Phe Met Asp Arg Leu Ala Ser Lys Lys Leu Cys 
            20                  25                  30          


Ala Asp Asp Glu Cys Val Tyr Thr Ile Ser Leu Ala Ser Ala Gln Glu 
        35                  40                  45              


Asp Tyr Asn Ala Pro Asp Cys Arg Phe Ile Asn Val Lys Lys Gly Gln 
    50                  55                  60                  


Gln Ile Tyr Val Tyr Ser Lys Leu Val Lys Glu Asn Gly Ala Gly Glu 
65                  70                  75                  80  


Phe Trp Ala Gly Ser Val Tyr Gly Asp Gly Gln Asp Glu Met Gly Val 
                85                  90                  95      


Val Gly Tyr Phe Pro Arg Asn Leu Val Lys Glu Gln Arg Val Tyr Gln 
            100                 105                 110         


Glu Ala Thr Lys Glu Val Pro Thr Thr Asp Ile Asp Phe Phe Cys Glu 
        115                 120                 125             


<210>  9881
<211>  89
<212>  PRT
<213>  Homo Sapiens

<400>  9881

Met Gln Ala Cys Met Val Pro Gly Leu Ala Leu Cys Leu Leu Leu Gly 
1               5                   10                  15      


Pro Leu Ala Gly Ala Lys Pro Val Gln Glu Glu Gly Asp Pro Tyr Ala 
            20                  25                  30          


Glu Leu Pro Ala Met Pro Tyr Trp Pro Phe Ser Thr Ser Asp Phe Trp 
        35                  40                  45              


Asn Tyr Val Gln His Phe Gln Ala Leu Gly Ala Tyr Pro Gln Ile Glu 
    50                  55                  60                  


Asp Met Ala Arg Thr Phe Phe Ala His Phe Pro Leu Gly Ser Thr Leu 
65                  70                  75                  80  


Gly Phe His Val Pro Tyr Gln Glu Asp 
                85                  


<210>  9882
<211>  89
<212>  PRT
<213>  Homo Sapiens

<400>  9882

Met Gln Ala Cys Met Val Pro Gly Leu Ala Leu Cys Leu Leu Leu Gly 
1               5                   10                  15      


Pro Leu Ala Gly Ala Lys Pro Val Gln Glu Glu Gly Asp Pro Tyr Ala 
            20                  25                  30          


Glu Leu Pro Ala Met Pro Tyr Trp Pro Phe Ser Thr Ser Asp Phe Trp 
        35                  40                  45              


Asn Tyr Val Gln His Phe Gln Ala Leu Gly Ala Tyr Pro Gln Ile Glu 
    50                  55                  60                  


Asp Met Ala Arg Thr Phe Phe Ala His Phe Pro Leu Gly Ser Thr Leu 
65                  70                  75                  80  


Gly Phe His Val Pro Tyr Gln Glu Asp 
                85                  


<210>  9883
<211>  1134
<212>  PRT
<213>  Homo Sapiens

<400>  9883

Met Gly Leu Leu Ala Ser Ala Gly Leu Leu Leu Leu Leu Val Ile Gly 
1               5                   10                  15      


His Pro Arg Ser Leu Gly Leu Lys Cys Gly Ile Arg Met Val Asn Met 
            20                  25                  30          


Lys Ser Lys Glu Pro Ala Val Gly Ser Arg Phe Phe Ser Arg Ile Ser 
        35                  40                  45              


Ser Trp Arg Asn Ser Thr Val Thr Gly His Pro Trp Gln Val Ser Leu 
    50                  55                  60                  


Lys Ser Asp Glu His His Phe Cys Gly Gly Ser Leu Ile Gln Glu Asp 
65                  70                  75                  80  


Arg Val Val Thr Ala Ala His Cys Leu Asp Ser Leu Ser Glu Lys Gln 
                85                  90                  95      


Leu Lys Asn Ile Thr Val Thr Ser Gly Glu Tyr Ser Leu Phe Gln Lys 
            100                 105                 110         


Asp Lys Gln Glu Gln Asn Ile Pro Val Ser Lys Ile Ile Thr His Pro 
        115                 120                 125             


Glu Tyr Asn Ser Arg Glu Tyr Met Ser Pro Asp Ile Ala Leu Leu Tyr 
    130                 135                 140                 


Leu Lys His Lys Val Lys Phe Gly Asn Ala Val Gln Pro Ile Cys Leu 
145                 150                 155                 160 


Pro Asp Ser Asp Asp Lys Val Glu Pro Gly Ile Leu Cys Leu Ser Ser 
                165                 170                 175     


Gly Trp Gly Lys Ile Ser Lys Thr Ser Glu Tyr Ser Asn Val Leu Gln 
            180                 185                 190         


Glu Met Glu Leu Pro Ile Met Asp Asp Arg Ala Cys Asn Thr Val Leu 
        195                 200                 205             


Lys Ser Met Asn Leu Pro Pro Leu Gly Arg Thr Met Leu Cys Ala Gly 
    210                 215                 220                 


Phe Pro Asp Trp Gly Met Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro 
225                 230                 235                 240 


Leu Val Cys Arg Arg Gly Gly Gly Ile Trp Ile Leu Ala Gly Ile Thr 
                245                 250                 255     


Ser Trp Val Ala Gly Cys Ala Gly Gly Ser Val Pro Val Arg Asn Asn 
            260                 265                 270         


His Val Lys Ala Ser Leu Gly Ile Phe Ser Lys Val Ser Glu Leu Met 
        275                 280                 285             


Asp Phe Ile Thr Gln Asn Leu Phe Thr Gly Leu Asp Arg Gly Gln Pro 
    290                 295                 300                 


Leu Ser Lys Val Gly Ser Arg Tyr Ile Thr Lys Ala Leu Ser Ser Val 
305                 310                 315                 320 


Gln Glu Val Asn Gly Ser Gln Arg Gly Lys Gly Ile Leu Asp Met Glu 
                325                 330                 335     


Lys Gln Val Gly Cys Asp His Asp Tyr Val Ser Leu Arg Ser Ser Ser 
            340                 345                 350         


Gly Val Leu Phe Asn Gln Arg Ser Leu Met Glu Asp Asp Gly Lys Gln 
        355                 360                 365             


Asn Lys Arg Val Cys Gly Lys Ile Leu Pro Ser Pro Leu Leu Ala Glu 
    370                 375                 380                 


Thr Ser Glu Ala Met Val Pro Phe Val Ser Asp Thr Glu Asp Ser Gly 
385                 390                 395                 400 


Ser Gly Phe Glu Leu Thr Val Thr Ala Val Gln Lys Ser Glu Ala Gly 
                405                 410                 415     


Ser Gly Cys Gly Ser Leu Ala Ile Leu Val Glu Glu Gly Thr Asn His 
            420                 425                 430         


Ser Ala Lys Tyr Pro Asp Leu Tyr Pro Ser Asn Thr Arg Cys His Trp 
        435                 440                 445             


Phe Ile Cys Ala Pro Glu Lys His Ile Ile Lys Leu Thr Phe Glu Asp 
    450                 455                 460                 


Phe Ala Val Lys Phe Ser Pro Asn Cys Ile Tyr Asp Ala Val Val Ile 
465                 470                 475                 480 


Tyr Gly Asp Ser Glu Glu Lys His Lys Leu Ala Lys Leu Cys Gly Met 
                485                 490                 495     


Leu Thr Ile Thr Ser Ile Phe Ser Ser Ser Asn Met Thr Val Ile Tyr 
            500                 505                 510         


Phe Lys Ser Asp Gly Lys Asn Arg Leu Gln Gly Phe Lys Ala Arg Phe 
        515                 520                 525             


Thr Ile Leu Pro Ser Glu Ser Leu Asn Lys Phe Glu Pro Lys Leu Pro 
    530                 535                 540                 


Pro Gln Asn Asn Pro Val Ser Thr Val Lys Ala Ile Leu His Asp Val 
545                 550                 555                 560 


Cys Gly Ile Pro Pro Phe Ser Pro Gln Trp Leu Ser Arg Arg Ile Ala 
                565                 570                 575     


Gly Gly Glu Glu Ala Cys Pro His Cys Trp Pro Trp Gln Val Gly Leu 
            580                 585                 590         


Arg Phe Leu Gly Asp Tyr Gln Cys Gly Gly Ala Ile Ile Asn Pro Val 
        595                 600                 605             


Trp Ile Leu Thr Ala Ala His Cys Val Gln Leu Lys Asn Asn Pro Leu 
    610                 615                 620                 


Ser Trp Thr Ile Ile Ala Gly Asp His Asp Arg Asn Leu Lys Glu Ser 
625                 630                 635                 640 


Thr Glu Gln Val Arg Arg Ala Lys His Ile Ile Val His Glu Asp Phe 
                645                 650                 655     


Asn Thr Leu Ser Tyr Asp Ser Asp Ile Ala Leu Ile Gln Leu Ser Ser 
            660                 665                 670         


Pro Leu Glu Tyr Asn Ser Val Val Arg Pro Val Cys Leu Pro His Ser 
        675                 680                 685             


Ala Glu Pro Leu Phe Ser Ser Glu Ile Cys Ala Val Thr Gly Trp Gly 
    690                 695                 700                 


Ser Ile Ser Ala Asp Gly Gly Leu Ala Ser Arg Leu Gln Gln Ile Gln 
705                 710                 715                 720 


Val His Val Leu Glu Arg Glu Val Cys Glu His Thr Tyr Tyr Ser Ala 
                725                 730                 735     


His Pro Gly Gly Ile Thr Glu Lys Met Ile Cys Ala Gly Phe Ala Ala 
            740                 745                 750         


Ser Gly Glu Lys Asp Phe Cys Gln Gly Asp Ser Gly Gly Pro Leu Val 
        755                 760                 765             


Cys Arg His Glu Asn Gly Pro Phe Val Leu Tyr Gly Ile Val Ser Trp 
    770                 775                 780                 


Gly Ala Gly Cys Val Gln Pro Trp Lys Pro Gly Val Phe Ala Arg Val 
785                 790                 795                 800 


Met Ile Phe Leu Asp Trp Ile Gln Ser Lys Ile Asn Gly Pro Ala Ser 
                805                 810                 815     


Leu Gln Thr Asn Asn Lys Cys Lys Thr Leu Lys Gln Gln Leu Pro Pro 
            820                 825                 830         


Pro Thr Pro Ser Pro Asp Ser Ala Ser Trp Pro Gly Cys Cys Ser Glu 
        835                 840                 845             


Ala Glu Leu Glu Lys Pro Arg Gly Phe Phe Pro Thr Pro Arg Tyr Leu 
    850                 855                 860                 


Leu Asp Tyr Arg Gly Arg Leu Glu Cys Ser Trp Val Leu Arg Val Ser 
865                 870                 875                 880 


Ala Ser Ser Met Ala Lys Phe Thr Ile Glu Tyr Leu Ser Leu Leu Gly 
                885                 890                 895     


Ser Pro Val Cys Gln Asp Ser Val Leu Ile Ile Tyr Glu Glu Arg His 
            900                 905                 910         


Ser Lys Arg Lys Thr Ala Gly Gly Leu His Gly Arg Arg Leu Tyr Ser 
        915                 920                 925             


Met Thr Phe Met Ser Pro Gly Pro Leu Val Arg Val Thr Phe His Ala 
    930                 935                 940                 


Leu Val Arg Gly Ala Phe Gly Ile Ser Tyr Ile Val Leu Lys Val Leu 
945                 950                 955                 960 


Gly Pro Lys Asp Ser Lys Ile Thr Arg Leu Ser Gln Ser Ser Asn Arg 
                965                 970                 975     


Glu His Leu Val Pro Cys Glu Asp Val Leu Leu Thr Lys Pro Glu Gly 
            980                 985                 990         


Ile Met Gln Ile Pro Arg Asn Ser  His Arg Thr Thr Met  Gly Cys Gln 
        995                 1000                 1005             


Trp Arg  Leu Val Ala Pro Leu  Asn His Ile Ile Gln  Leu Asn Ile 
    1010                 1015                 1020             


Ile Asn  Phe Pro Met Lys Pro  Thr Thr Phe Val Cys  His Gly His 
    1025                 1030                 1035             


Leu Arg  Val Tyr Glu Gly Phe  Gly Pro Gly Lys Lys  Leu Ile Ala 
    1040                 1045                 1050             


Ser Phe  Ala Gly Thr Leu Ala  Met Ile Leu Thr Lys  Asp Ile Leu 
    1055                 1060                 1065             


Lys Arg  Glu Lys Leu Asn Phe  Ile Asn Thr Tyr Ile  Met His Ile 
    1070                 1075                 1080             


Trp Glu  Asn Ser Val Tyr Asp  Asn Val Arg Ser Val  Gly Lys Arg 
    1085                 1090                 1095             


Lys Gln  Lys Lys Phe Ala Ser  Asn Leu Ser Tyr Ser  Met Glu Ala 
    1100                 1105                 1110             


Glu Lys  Ser Arg Ile Gln Val  Pro Ala Asp Leu Val  Pro Ala Lys 
    1115                 1120                 1125             


Gly Ser  Leu Ser Gly Ser 
    1130                 


<210>  9884
<211>  80
<212>  PRT
<213>  Homo Sapiens

<400>  9884

Arg Glu His Leu Val Pro Cys Glu Asp Val Leu Leu Thr Lys Pro Glu 
1               5                   10                  15      


Gly Ile Met Gln Ile Pro Arg Asn Ser His Arg Thr Thr Met Gly Cys 
            20                  25                  30          


Gln Trp Arg Leu Val Ala Pro Leu Asn His Ile Ile Gln Leu Asn Ile 
        35                  40                  45              


Ile Asn Phe Pro Met Lys Pro Thr Thr Phe Val Cys His Gly His Leu 
    50                  55                  60                  


Arg Val Tyr Glu Gly Phe Gly Pro Gly Lys Lys Leu Ile Gly Glu Cys 
65                  70                  75                  80  


<210>  9885
<211>  121
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9885

Xaa Lys Ile Thr Arg Leu Ser Gln Ser Ser Asn Arg Glu His Leu Val 
1               5                   10                  15      


Pro Cys Glu Asp Val Leu Leu Thr Lys Pro Glu Gly Ile Met Gln Ile 
            20                  25                  30          


Pro Arg Asn Ser His Arg Thr Thr Met Gly Cys Gln Trp Arg Leu Val 
        35                  40                  45              


Ala Pro Leu Asn His Ile Ile Gln Leu Asn Ile Ile Asn Phe Pro Met 
    50                  55                  60                  


Lys Pro Thr Thr Phe Val Cys His Gly His Leu Arg Val Tyr Glu Gly 
65                  70                  75                  80  


Phe Gly Pro Gly Lys Lys Leu Ile Ala His Leu His Gly Ser Lys Lys 
                85                  90                  95      


Glu Phe Ile Leu Ile Ser Ser Ala Ala Tyr Leu Thr Val His Phe Lys 
            100                 105                 110         


Thr Asp Glu Ser Glu Arg Lys Arg Phe 
        115                 120     


<210>  9886
<211>  565
<212>  PRT
<213>  Homo Sapiens

<400>  9886

Met Leu Ile Ser Arg Asn Lys Leu Ile Leu Leu Leu Gly Ile Val Phe 
1               5                   10                  15      


Phe Glu Arg Gly Lys Ser Ala Thr Leu Ser Leu Pro Lys Ala Pro Ser 
            20                  25                  30          


Cys Gly Gln Ser Leu Val Lys Val Gln Pro Trp Asn Tyr Phe Asn Ile 
        35                  40                  45              


Phe Ser Arg Ile Leu Gly Gly Ser Gln Val Glu Lys Gly Ser Tyr Pro 
    50                  55                  60                  


Trp Gln Val Ser Leu Lys Gln Arg Gln Lys His Ile Cys Gly Gly Ser 
65                  70                  75                  80  


Ile Val Ser Pro Gln Trp Val Ile Thr Ala Ala His Cys Ile Ala Asn 
                85                  90                  95      


Arg Asn Ile Val Ser Thr Leu Asn Val Thr Ala Gly Glu Tyr Asp Leu 
            100                 105                 110         


Ser Gln Thr Asp Pro Gly Glu Gln Thr Leu Thr Ile Glu Thr Val Ile 
        115                 120                 125             


Ile His Pro His Phe Ser Thr Lys Lys Pro Met Asp Tyr Asp Ile Ala 
    130                 135                 140                 


Leu Leu Lys Met Ala Gly Ala Phe Gln Phe Gly His Phe Val Gly Pro 
145                 150                 155                 160 


Ile Cys Leu Pro Glu Leu Arg Glu Gln Phe Glu Ala Gly Phe Ile Cys 
                165                 170                 175     


Thr Thr Ala Gly Trp Gly Arg Leu Thr Glu Gly Gly Val Leu Ser Gln 
            180                 185                 190         


Val Leu Gln Glu Val Asn Leu Pro Ile Leu Thr Trp Glu Glu Cys Val 
        195                 200                 205             


Ala Ala Leu Leu Thr Leu Lys Arg Pro Ile Ser Gly Lys Thr Phe Leu 
    210                 215                 220                 


Cys Thr Gly Phe Pro Asp Gly Gly Arg Asp Ala Cys Gln Gly Asp Ser 
225                 230                 235                 240 


Gly Gly Ser Leu Met Cys Arg Asn Lys Lys Gly Ala Trp Thr Leu Ala 
                245                 250                 255     


Gly Val Thr Ser Trp Gly Leu Gly Cys Gly Arg Gly Trp Arg Asn Asn 
            260                 265                 270         


Val Arg Lys Ser Asp Gln Gly Ser Pro Gly Ile Phe Thr Asp Ile Ser 
        275                 280                 285             


Lys Val Leu Pro Trp Ile His Glu His Ile Gln Thr Gly Asn Arg Arg 
    290                 295                 300                 


Lys Ser Ser Arg Ala Trp Cys Ser Glu Gln Asp Val Ile Val Ser Gly 
305                 310                 315                 320 


Ala Glu Gly Lys Leu His Phe Pro Glu Ser Leu His Leu Tyr Tyr Glu 
                325                 330                 335     


Ser Lys Gln Arg Cys Val Trp Thr Leu Leu Val Pro Glu Glu Met His 
            340                 345                 350         


Val Leu Leu Ser Phe Ser His Leu Asp Val Glu Ser Cys His His Ser 
        355                 360                 365             


Tyr Leu Ser Met Tyr Ser Leu Glu Asp Arg Pro Ile Gly Lys Phe Cys 
    370                 375                 380                 


Gly Glu Ser Leu Pro Ser Ser Ile Leu Ile Gly Ser Asn Ser Leu Arg 
385                 390                 395                 400 


Leu Lys Phe Val Ser Asp Ala Thr Asp Asn Ala Ala Gly Phe Asn Leu 
                405                 410                 415     


Thr Tyr Lys Ala Leu Lys Pro Asn Tyr Ile Pro Asp Ser Gly Cys Ser 
            420                 425                 430         


Tyr Leu Thr Val Leu Phe Glu Glu Gly Leu Ile Gln Ser Leu Asn Tyr 
        435                 440                 445             


Pro Glu Asn Tyr Ser Asp Lys Ala Asn Cys Asp Trp Ile Phe Gln Ala 
    450                 455                 460                 


Ser Lys His His Leu Ile Lys Leu Ser Phe Gln Ser Leu Glu Ile Glu 
465                 470                 475                 480 


Glu Ser Gly Asp Cys Thr Ser Asp Tyr Val Thr Val His Ser Asp Val 
                485                 490                 495     


Glu Arg Lys Lys Glu Ile Ala Arg Leu Cys Gly Tyr Asp Val Pro Thr 
            500                 505                 510         


Pro Val Leu Ser Pro Ser Ser Ile Met Leu Ile Ser Phe Gln Ser Asp 
        515                 520                 525             


Glu Asn Gly Thr Cys Arg Gly Phe Gln Ala Thr Val Ser Phe Ile Pro 
    530                 535                 540                 


Lys Ala Val Tyr Pro Asp Leu Asn Ile Ser Ile Ser Glu Asp Glu Ser 
545                 550                 555                 560 


Met Phe Leu Glu Thr 
                565 


<210>  9887
<211>  565
<212>  PRT
<213>  Homo Sapiens

<400>  9887

Met Leu Ile Ser Arg Asn Lys Leu Ile Leu Leu Leu Gly Ile Val Phe 
1               5                   10                  15      


Phe Glu Arg Gly Lys Ser Ala Thr Leu Ser Leu Pro Lys Ala Pro Ser 
            20                  25                  30          


Cys Gly Gln Ser Leu Val Lys Val Gln Pro Trp Asn Tyr Phe Asn Ile 
        35                  40                  45              


Phe Ser Arg Ile Leu Gly Gly Ser Gln Val Glu Lys Gly Ser Tyr Pro 
    50                  55                  60                  


Trp Gln Val Ser Leu Lys Gln Arg Gln Lys His Ile Cys Gly Gly Ser 
65                  70                  75                  80  


Ile Val Ser Pro Gln Trp Val Ile Thr Ala Ala His Cys Ile Ala Asn 
                85                  90                  95      


Arg Asn Ile Val Ser Thr Leu Asn Val Thr Ala Gly Glu Tyr Asp Leu 
            100                 105                 110         


Ser Gln Thr Asp Pro Gly Glu Gln Thr Leu Thr Ile Glu Thr Val Ile 
        115                 120                 125             


Ile His Pro His Phe Ser Thr Lys Lys Pro Met Asp Tyr Asp Ile Ala 
    130                 135                 140                 


Leu Leu Lys Met Ala Gly Ala Phe Gln Phe Gly His Phe Val Gly Pro 
145                 150                 155                 160 


Ile Cys Leu Pro Glu Leu Arg Glu Gln Phe Glu Ala Gly Phe Ile Cys 
                165                 170                 175     


Thr Thr Ala Gly Trp Gly Arg Leu Thr Glu Gly Gly Val Leu Ser Gln 
            180                 185                 190         


Val Leu Gln Glu Val Asn Leu Pro Ile Leu Thr Trp Glu Glu Cys Val 
        195                 200                 205             


Ala Ala Leu Leu Thr Leu Lys Arg Pro Ile Ser Gly Lys Thr Phe Leu 
    210                 215                 220                 


Cys Thr Gly Phe Pro Asp Gly Gly Arg Asp Ala Cys Gln Gly Asp Ser 
225                 230                 235                 240 


Gly Gly Ser Leu Met Cys Arg Asn Lys Lys Gly Ala Trp Thr Leu Ala 
                245                 250                 255     


Gly Val Thr Ser Trp Gly Leu Gly Cys Gly Arg Gly Trp Arg Asn Asn 
            260                 265                 270         


Val Arg Lys Ser Asp Gln Gly Ser Pro Gly Ile Phe Thr Asp Ile Ser 
        275                 280                 285             


Lys Val Leu Pro Trp Ile His Glu His Ile Gln Thr Gly Asn Arg Arg 
    290                 295                 300                 


Lys Ser Ser Arg Ala Trp Cys Ser Glu Gln Asp Val Ile Val Ser Gly 
305                 310                 315                 320 


Ala Glu Gly Lys Leu His Phe Pro Glu Ser Leu His Leu Tyr Tyr Glu 
                325                 330                 335     


Ser Lys Gln Arg Cys Val Trp Thr Leu Leu Val Pro Glu Glu Met His 
            340                 345                 350         


Val Leu Leu Ser Phe Ser His Leu Asp Val Glu Ser Cys His His Ser 
        355                 360                 365             


Tyr Leu Ser Met Tyr Ser Leu Glu Asp Arg Pro Ile Gly Lys Phe Cys 
    370                 375                 380                 


Gly Glu Ser Leu Pro Ser Ser Ile Leu Ile Gly Ser Asn Ser Leu Arg 
385                 390                 395                 400 


Leu Lys Phe Val Ser Asp Ala Thr Asp Asn Ala Ala Gly Phe Asn Leu 
                405                 410                 415     


Thr Tyr Lys Ala Leu Lys Pro Asn Tyr Ile Pro Asp Ser Gly Cys Ser 
            420                 425                 430         


Tyr Leu Thr Val Leu Phe Glu Glu Gly Leu Ile Gln Ser Leu Asn Tyr 
        435                 440                 445             


Pro Glu Asn Tyr Ser Asp Lys Ala Asn Cys Asp Trp Ile Phe Gln Ala 
    450                 455                 460                 


Ser Lys His His Leu Ile Lys Leu Ser Phe Gln Ser Leu Glu Ile Glu 
465                 470                 475                 480 


Glu Ser Gly Asp Cys Thr Ser Asp Tyr Val Thr Val His Ser Asp Val 
                485                 490                 495     


Glu Arg Lys Lys Glu Ile Ala Arg Leu Cys Gly Tyr Asp Val Pro Thr 
            500                 505                 510         


Pro Val Leu Ser Pro Ser Ser Ile Met Leu Ile Ser Phe Gln Ser Asp 
        515                 520                 525             


Glu Asn Gly Thr Cys Arg Gly Phe Gln Ala Thr Val Ser Phe Ile Pro 
    530                 535                 540                 


Lys Ala Val Tyr Pro Asp Leu Asn Ile Ser Ile Ser Glu Asp Glu Ser 
545                 550                 555                 560 


Met Phe Leu Glu Thr 
                565 


<210>  9888
<211>  678
<212>  PRT
<213>  Homo Sapiens

<400>  9888

Met Trp Lys Leu Leu Leu Trp Val Gly Leu Val Leu Val Leu Lys His 
1               5                   10                  15      


His Asp Gly Ala Ala His Lys Leu Val Cys Tyr Phe Thr Asn Trp Ala 
            20                  25                  30          


His Ser Arg Pro Gly Pro Ala Ser Ile Leu Pro His Asp Leu Asp Pro 
        35                  40                  45              


Phe Leu Cys Thr His Leu Ile Phe Ala Phe Ala Ser Met Asn Asn Asn 
    50                  55                  60                  


Gln Ile Val Ala Lys Asp Leu Gln Asp Glu Lys Ile Leu Tyr Pro Glu 
65                  70                  75                  80  


Phe Asn Lys Leu Lys Glu Arg Asn Arg Glu Leu Lys Thr Leu Leu Ser 
                85                  90                  95      


Ile Gly Gly Trp Asn Phe Gly Thr Ser Arg Phe Thr Thr Met Leu Ser 
            100                 105                 110         


Thr Phe Ala Asn Arg Glu Lys Phe Ile Ala Ser Val Ile Ser Leu Leu 
        115                 120                 125             


Arg Thr His Asp Phe Asp Gly Leu Asp Leu Phe Phe Leu Tyr Pro Gly 
    130                 135                 140                 


Leu Arg Gly Ser Pro Met His Asp Arg Trp Thr Phe Leu Phe Leu Ile 
145                 150                 155                 160 


Glu Glu Leu Leu Phe Ala Phe Arg Lys Glu Ala Leu Leu Thr Met Arg 
                165                 170                 175     


Pro Arg Leu Leu Leu Ser Ala Ala Val Ser Gly Val Pro His Ile Val 
            180                 185                 190         


Gln Thr Ser Tyr Asp Val Arg Phe Leu Gly Arg Leu Leu Asp Phe Ile 
        195                 200                 205             


Asn Val Leu Ser Tyr Asp Leu His Gly Ser Trp Glu Arg Phe Thr Gly 
    210                 215                 220                 


His Asn Ser Pro Leu Phe Ser Leu Pro Glu Asp Pro Lys Ser Ser Ala 
225                 230                 235                 240 


Tyr Ala Met Asn Tyr Trp Arg Lys Leu Gly Ala Pro Ser Glu Lys Leu 
                245                 250                 255     


Ile Met Gly Ile Pro Thr Tyr Gly Arg Thr Phe Arg Leu Leu Lys Ala 
            260                 265                 270         


Ser Lys Asn Gly Leu Gln Ala Arg Ala Ile Gly Pro Ala Ser Pro Gly 
        275                 280                 285             


Lys Tyr Thr Lys Gln Glu Gly Phe Leu Ala Tyr Phe Glu Ile Cys Ser 
    290                 295                 300                 


Phe Val Trp Gly Ala Lys Lys His Trp Ile Asp Tyr Gln Tyr Val Pro 
305                 310                 315                 320 


Tyr Ala Asn Lys Gly Lys Glu Trp Val Gly Tyr Asp Asn Ala Ile Ser 
                325                 330                 335     


Phe Ser Tyr Lys Ala Trp Phe Ile Arg Arg Glu His Phe Gly Gly Ala 
            340                 345                 350         


Met Val Trp Thr Leu Asp Met Asp Asp Val Arg Gly Thr Phe Cys Gly 
        355                 360                 365             


Thr Gly Pro Phe Pro Leu Val Tyr Val Leu Asn Asp Ile Leu Val Arg 
    370                 375                 380                 


Ala Glu Phe Ser Ser Thr Ser Leu Pro Gln Phe Trp Leu Ser Ser Ala 
385                 390                 395                 400 


Val Asn Ser Ser Ser Thr Asp Pro Glu Arg Leu Ala Val Thr Thr Ala 
                405                 410                 415     


Trp Thr Thr Asp Ser Lys Ile Leu Pro Pro Gly Gly Glu Ala Gly Val 
            420                 425                 430         


Thr Glu Ile His Gly Lys Cys Glu Asn Met Thr Ile Thr Pro Arg Gly 
        435                 440                 445             


Thr Thr Val Thr Pro Thr Lys Glu Thr Val Ser Leu Gly Lys His Thr 
    450                 455                 460                 


Val Ala Leu Gly Glu Lys Thr Glu Ile Thr Gly Ala Met Thr Met Thr 
465                 470                 475                 480 


Ser Val Gly His Gln Ser Met Thr Pro Gly Glu Lys Ala Leu Thr Pro 
                485                 490                 495     


Val Gly His Gln Ser Val Thr Thr Gly Gln Lys Thr Leu Thr Ser Val 
            500                 505                 510         


Gly Tyr Gln Ser Val Thr Pro Gly Glu Lys Thr Leu Thr Pro Val Gly 
        515                 520                 525             


His Gln Ser Val Thr Pro Val Ser His Gln Ser Val Ser Pro Gly Gly 
    530                 535                 540                 


Thr Thr Met Thr Pro Val His Phe Gln Thr Glu Thr Leu Arg Gln Asn 
545                 550                 555                 560 


Thr Val Ala Pro Arg Arg Lys Ala Val Ala Arg Glu Lys Val Thr Val 
                565                 570                 575     


Pro Ser Arg Asn Ile Ser Val Thr Pro Glu Gly Gln Thr Met Pro Leu 
            580                 585                 590         


Arg Gly Glu Asn Leu Thr Ser Glu Val Gly Thr His Pro Arg Met Gly 
        595                 600                 605             


Asn Leu Gly Leu Gln Met Glu Ala Glu Asn Arg Met Met Leu Ser Ser 
    610                 615                 620                 


Ser Pro Val Ile Gln Leu Pro Glu Gln Thr Pro Leu Ala Phe Asp Asn 
625                 630                 635                 640 


Arg Phe Val Pro Ile Tyr Gly Asn His Ser Ser Val Asn Ser Val Thr 
                645                 650                 655     


Pro Gln Thr Ser Pro Leu Ser Leu Lys Lys Glu Ile Pro Glu Asn Ser 
            660                 665                 670         


Ala Val Asp Glu Glu Ala 
        675             


<210>  9889
<211>  520
<212>  PRT
<213>  Homo Sapiens

<400>  9889

Met Ala Ala Leu Lys Leu Leu Ser Ser Gly Leu Arg Leu Cys Ala Ser 
1               5                   10                  15      


Ala Arg Gly Ser Gly Ala Thr Trp Tyr Lys Gly Cys Val Cys Ser Phe 
            20                  25                  30          


Ser Thr Ser Ala His Arg His Thr Lys Phe Tyr Thr Asp Pro Val Glu 
        35                  40                  45              


Ala Val Lys Asp Ile Pro Asp Gly Ala Thr Val Leu Val Gly Gly Phe 
    50                  55                  60                  


Gly Leu Cys Gly Ile Pro Glu Asn Leu Ile Asp Ala Leu Leu Lys Thr 
65                  70                  75                  80  


Gly Val Lys Gly Leu Thr Ala Val Ser Asn Asn Ala Gly Val Asp Asn 
                85                  90                  95      


Phe Gly Leu Gly Leu Leu Leu Arg Ser Lys Gln Ile Lys Arg Met Val 
            100                 105                 110         


Ser Ser Tyr Val Gly Glu Asn Ala Glu Phe Glu Arg Gln Tyr Leu Ser 
        115                 120                 125             


Gly Glu Leu Glu Val Glu Leu Thr Pro Gln Gly Thr Leu Ala Glu Arg 
    130                 135                 140                 


Ile Arg Ala Gly Gly Ala Gly Val Pro Ala Phe Tyr Thr Pro Thr Gly 
145                 150                 155                 160 


Tyr Gly Thr Leu Val Gln Glu Gly Gly Ser Pro Ile Lys Tyr Asn Lys 
                165                 170                 175     


Asp Gly Ser Val Ala Ile Ala Ser Lys Pro Arg Glu Val Arg Glu Phe 
            180                 185                 190         


Asn Gly Gln His Phe Ile Leu Glu Glu Ala Ile Thr Gly Asp Phe Ala 
        195                 200                 205             


Leu Val Lys Ala Trp Lys Ala Asp Arg Ala Gly Asn Val Ile Phe Arg 
    210                 215                 220                 


Lys Ser Ala Arg Asn Phe Asn Leu Pro Met Cys Lys Ala Ala Glu Thr 
225                 230                 235                 240 


Thr Val Val Glu Val Glu Glu Ile Val Asp Ile Gly Ala Phe Ala Pro 
                245                 250                 255     


Glu Asp Ile His Ile Pro Gln Ile Tyr Val His Arg Leu Ile Lys Gly 
            260                 265                 270         


Glu Lys Tyr Glu Lys Arg Ile Glu Arg Leu Ser Ile Arg Lys Glu Gly 
        275                 280                 285             


Asp Gly Glu Ala Lys Ser Ala Lys Pro Gly Asp Asp Val Arg Glu Arg 
    290                 295                 300                 


Ile Ile Lys Arg Ala Ala Leu Glu Phe Glu Asp Gly Met Tyr Ala Asn 
305                 310                 315                 320 


Leu Gly Ile Gly Ile Pro Leu Leu Ala Ser Asn Phe Ile Ser Pro Asn 
                325                 330                 335     


Ile Thr Val His Leu Gln Ser Glu Asn Gly Val Leu Gly Leu Gly Pro 
            340                 345                 350         


Tyr Pro Arg Gln His Glu Ala Asp Ala Asp Leu Ile Asn Ala Gly Lys 
        355                 360                 365             


Glu Thr Val Thr Ile Leu Pro Gly Ala Ser Phe Phe Ser Ser Asp Glu 
    370                 375                 380                 


Ser Phe Ala Met Ile Arg Gly Gly His Val Asp Leu Thr Met Leu Gly 
385                 390                 395                 400 


Ala Met Gln Val Ser Lys Tyr Gly Asp Leu Ala Asn Trp Met Ile Pro 
                405                 410                 415     


Gly Lys Met Val Lys Gly Met Gly Gly Ala Met Asp Leu Val Ser Ser 
            420                 425                 430         


Ala Lys Thr Lys Val Val Val Thr Met Glu His Ser Ala Lys Gly Asn 
        435                 440                 445             


Ala His Lys Ile Met Glu Lys Cys Thr Leu Pro Leu Thr Gly Lys Gln 
    450                 455                 460                 


Cys Val Asn Arg Ile Ile Thr Glu Lys Ala Val Phe Asp Val Asp Lys 
465                 470                 475                 480 


Lys Lys Gly Leu Thr Leu Ile Glu Leu Trp Glu Gly Leu Thr Val Asp 
                485                 490                 495     


Asp Val Gln Lys Ser Thr Gly Cys Asp Phe Ala Val Ser Pro Lys Leu 
            500                 505                 510         


Met Pro Met Gln Gln Ile Ala Asn 
        515                 520 


<210>  9890
<211>  123
<212>  PRT
<213>  Homo Sapiens

<400>  9890

Met Leu Gly Ala Met Gln Val Ser Lys Tyr Gly Asp Leu Ala Asn Trp 
1               5                   10                  15      


Met Ile Pro Gly Lys Met Val Lys Gly Met Gly Gly Ala Met Asp Leu 
            20                  25                  30          


Val Ser Ser Ala Lys Thr Lys Val Val Val Thr Met Glu His Ser Ala 
        35                  40                  45              


Lys Gly Asn Ala His Lys Ile Met Glu Lys Cys Thr Leu Pro Leu Thr 
    50                  55                  60                  


Gly Lys Gln Cys Val Asn Arg Ile Ile Thr Glu Lys Ala Val Phe Asp 
65                  70                  75                  80  


Val Asp Lys Lys Lys Gly Leu Thr Leu Ile Glu Leu Trp Glu Gly Leu 
                85                  90                  95      


Thr Val Asp Asp Val Gln Lys Ser Thr Gly Cys Asp Phe Ala Val Ser 
            100                 105                 110         


Pro Lys Leu Met Pro Met Gln Gln Ile Ala Asn 
        115                 120             


<210>  9891
<211>  123
<212>  PRT
<213>  Homo Sapiens

<400>  9891

Met Leu Gly Ala Met Gln Val Ser Lys Tyr Gly Asp Leu Ala Asn Trp 
1               5                   10                  15      


Met Ile Pro Gly Lys Met Val Lys Gly Met Gly Gly Ala Met Asp Leu 
            20                  25                  30          


Val Ser Ser Ala Lys Thr Lys Val Val Val Thr Met Glu His Ser Ala 
        35                  40                  45              


Lys Gly Asn Ala His Lys Ile Met Glu Lys Cys Thr Leu Pro Leu Thr 
    50                  55                  60                  


Gly Lys Gln Cys Val Asn Arg Ile Ile Thr Glu Lys Ala Val Phe Asp 
65                  70                  75                  80  


Val Asp Lys Lys Lys Gly Leu Thr Leu Ile Glu Leu Trp Glu Gly Leu 
                85                  90                  95      


Thr Val Asp Asp Val Gln Lys Ser Thr Gly Cys Asp Phe Ala Val Ser 
            100                 105                 110         


Pro Lys Leu Met Pro Met Gln Gln Ile Ala Asn 
        115                 120             


<210>  9892
<211>  334
<212>  PRT
<213>  Homo Sapiens

<400>  9892

Met Met Val Arg Glu Phe Asn Gly Gln His Phe Ile Leu Glu Glu Ala 
1               5                   10                  15      


Ile Thr Gly Asp Phe Ala Leu Val Lys Ala Trp Lys Ala Asp Arg Ala 
            20                  25                  30          


Gly Asn Val Ile Phe Arg Lys Ser Ala Arg Asn Phe Asn Leu Pro Met 
        35                  40                  45              


Cys Lys Ala Ala Glu Thr Thr Val Val Glu Val Glu Glu Ile Val Asp 
    50                  55                  60                  


Ile Gly Ala Phe Ala Pro Glu Asp Ile His Ile Pro Gln Ile Tyr Val 
65                  70                  75                  80  


His Arg Leu Ile Lys Gly Glu Lys Tyr Glu Lys Arg Ile Glu Arg Leu 
                85                  90                  95      


Ser Ile Arg Lys Glu Gly Asp Gly Glu Ala Lys Ser Ala Lys Pro Gly 
            100                 105                 110         


Asp Asp Val Arg Glu Arg Ile Ile Lys Arg Ala Ala Leu Glu Phe Glu 
        115                 120                 125             


Asp Gly Met Tyr Ala Asn Leu Gly Ile Gly Ile Pro Leu Leu Ala Ser 
    130                 135                 140                 


Asn Phe Ile Ser Pro Asn Ile Thr Val His Leu Gln Ser Glu Asn Gly 
145                 150                 155                 160 


Val Leu Gly Leu Gly Pro Tyr Pro Arg Gln His Glu Ala Asp Ala Asp 
                165                 170                 175     


Leu Ile Asn Ala Gly Lys Glu Thr Val Thr Ile Leu Pro Gly Ala Ser 
            180                 185                 190         


Phe Phe Ser Ser Asp Glu Ser Phe Ala Met Ile Arg Gly Gly His Val 
        195                 200                 205             


Asp Leu Thr Met Leu Gly Ala Met Gln Val Ser Lys Tyr Gly Asp Leu 
    210                 215                 220                 


Ala Asn Trp Met Ile Pro Gly Lys Met Val Lys Gly Met Gly Gly Ala 
225                 230                 235                 240 


Met Asp Leu Val Ser Ser Ala Lys Thr Lys Val Val Val Thr Met Glu 
                245                 250                 255     


His Ser Ala Lys Gly Asn Ala His Lys Ile Met Glu Lys Cys Thr Leu 
            260                 265                 270         


Pro Leu Thr Gly Lys Gln Cys Val Asn Arg Ile Ile Thr Glu Lys Ala 
        275                 280                 285             


Val Phe Asp Val Asp Lys Lys Lys Gly Leu Thr Leu Ile Glu Leu Trp 
    290                 295                 300                 


Glu Gly Leu Thr Val Asp Asp Val Gln Lys Ser Thr Gly Cys Asp Phe 
305                 310                 315                 320 


Ala Val Ser Pro Lys Leu Met Pro Met Gln Gln Ile Ala Asn 
                325                 330                 


<210>  9893
<211>  517
<212>  PRT
<213>  Homo Sapiens

<400>  9893

Met Ala Ala Leu Arg Leu Leu Ala Ser Val Leu Gly Arg Gly Val Pro 
1               5                   10                  15      


Ala Gly Gly Ser Gly Leu Ala Leu Ser Gln Gly Cys Ala Arg Cys Phe 
            20                  25                  30          


Ala Thr Ser Pro Arg Leu Arg Ala Lys Phe Tyr Ala Asp Pro Val Glu 
        35                  40                  45              


Met Val Lys Asp Ile Ser Asp Gly Ala Thr Val Met Ile Gly Gly Phe 
    50                  55                  60                  


Gly Leu Cys Gly Ile Pro Glu Asn Leu Ile Ala Ala Leu Leu Arg Thr 
65                  70                  75                  80  


Arg Val Lys Asp Leu Gln Val Val Ser Ser Asn Val Gly Val Glu Asp 
                85                  90                  95      


Phe Gly Leu Gly Leu Leu Leu Ala Ala Arg Gln Val Arg Arg Ile Val 
            100                 105                 110         


Cys Ser Tyr Val Gly Glu Asn Thr Leu Cys Glu Ser Gln Tyr Leu Ala 
        115                 120                 125             


Gly Glu Leu Glu Leu Glu Leu Thr Pro Gln Gly Thr Leu Ala Glu Arg 
    130                 135                 140                 


Ile Arg Ala Gly Gly Ala Gly Val Pro Ala Phe Tyr Thr Pro Thr Gly 
145                 150                 155                 160 


Tyr Gly Thr Leu Val Gln Glu Gly Gly Ala Pro Ile Arg Tyr Thr Pro 
                165                 170                 175     


Asp Gly His Leu Ala Leu Met Ser Gln Pro Arg Glu Val Arg Glu Phe 
            180                 185                 190         


Asn Gly Asp His Phe Leu Leu Glu Arg Ala Ile Arg Ala Asp Phe Ala 
        195                 200                 205             


Leu Val Lys Gly Trp Lys Ala Asp Arg Ala Gly Asn Val Val Phe Arg 
    210                 215                 220                 


Arg Ser Ala Arg Asn Phe Asn Val Pro Met Cys Lys Ala Ala Asp Val 
225                 230                 235                 240 


Thr Ala Val Glu Val Glu Glu Ile Val Glu Val Gly Ala Phe Pro Pro 
                245                 250                 255     


Glu Asp Ile His Val Pro Asn Ile Tyr Val Asp Arg Val Ile Lys Gly 
            260                 265                 270         


Gln Lys Tyr Glu Lys Arg Ile Glu Arg Leu Thr Ile Leu Lys Glu Glu 
        275                 280                 285             


Asp Gly Asp Ala Gly Lys Glu Glu Asp Ala Arg Thr Arg Ile Ile Arg 
    290                 295                 300                 


Arg Ala Ala Leu Glu Phe Glu Asp Gly Met Tyr Ala Asn Leu Gly Ile 
305                 310                 315                 320 


Gly Ile Pro Leu Leu Ala Ser Asn Phe Ile Ser Pro Ser Met Thr Val 
                325                 330                 335     


His Leu His Ser Glu Asn Gly Ile Leu Gly Leu Gly Pro Phe Pro Thr 
            340                 345                 350         


Glu Asp Glu Val Asp Ala Asp Leu Ile Asn Ala Gly Lys Gln Thr Val 
        355                 360                 365             


Thr Val Leu Pro Gly Gly Cys Phe Phe Ala Ser Asp Asp Ser Phe Ala 
    370                 375                 380                 


Met Ile Arg Gly Gly His Ile Gln Leu Thr Met Leu Gly Ala Met Gln 
385                 390                 395                 400 


Val Ser Lys Tyr Gly Asp Leu Ala Asn Trp Met Ile Pro Gly Lys Lys 
                405                 410                 415     


Val Lys Gly Met Gly Gly Ala Met Asp Leu Val Ser Ser Gln Lys Thr 
            420                 425                 430         


Arg Val Val Val Thr Met Gln His Cys Thr Lys Asp Asn Thr Pro Lys 
        435                 440                 445             


Ile Met Glu Lys Cys Thr Met Pro Leu Thr Gly Lys Arg Cys Val Asp 
    450                 455                 460                 


Arg Ile Ile Thr Glu Lys Ala Val Phe Asp Val His Arg Lys Lys Glu 
465                 470                 475                 480 


Leu Thr Leu Arg Glu Leu Trp Glu Gly Leu Thr Val Asp Asp Ile Lys 
                485                 490                 495     


Lys Ser Thr Gly Cys Ala Phe Ala Val Ser Pro Asn Leu Arg Pro Met 
            500                 505                 510         


Gln Gln Val Ala Pro 
        515         


<210>  9894
<211>  56
<212>  PRT
<213>  Homo Sapiens

<400>  9894

Met Ala Cys Ala Ala Val Met Ile Pro Gly Leu Leu Arg Cys Ser Val 
1               5                   10                  15      


Gly Ala Ile Arg Ile Glu Ala Ala Ser Leu Arg Leu Thr Leu Ser Thr 
            20                  25                  30          


Leu Arg His Leu Thr Leu Thr Arg Leu Cys Gln Gln Leu Arg Cys Val 
        35                  40                  45              


Glu Leu Pro Val Ser His Arg Gln 
    50                  55      


<210>  9895
<211>  312
<212>  PRT
<213>  Homo Sapiens

<400>  9895

Met Ala Cys Ala Ala Val Met Ile Pro Gly Leu Leu Arg Cys Ser Val 
1               5                   10                  15      


Gly Ala Ile Arg Ile Glu Ala Ala Ser Leu Arg Leu Thr Leu Ser Thr 
            20                  25                  30          


Leu Arg His Leu Thr Leu Thr Ser Ile Met Lys Ser Lys Arg Lys Thr 
        35                  40                  45              


Asp His Met Glu Arg Thr Ala Ser Val Leu Arg Arg Glu Ile Val Ser 
    50                  55                  60                  


Ala Ala Lys Val Cys Gly Ala Ala Ser Glu Ser Pro Ser Val Lys Ser 
65                  70                  75                  80  


Leu Arg Leu Leu Val Ala Asp Gln Asp Phe Ser Phe Lys Ala Gly Gln 
                85                  90                  95      


Trp Val Asp Phe Phe Ile Pro Gly Val Ser Val Val Gly Gly Phe Ser 
            100                 105                 110         


Ile Cys Ser Ser Pro Arg Leu Leu Glu Gln Glu Arg Val Ile Glu Leu 
        115                 120                 125             


Ala Val Lys Tyr Thr Asn His Pro Pro Ala Leu Trp Val His Asn Thr 
    130                 135                 140                 


Cys Thr Leu Asp Cys Glu Val Ala Val Arg Val Gly Gly Glu Phe Phe 
145                 150                 155                 160 


Phe Asp Pro Gln Pro Ala Asp Ala Ser Arg Asn Leu Val Leu Ile Ala 
                165                 170                 175     


Gly Gly Val Gly Ile Asn Pro Leu Leu Ser Ile Leu Arg His Ala Ala 
            180                 185                 190         


Asp Leu Leu Arg Glu Gln Ala Asn Lys Arg Asn Gly Tyr Glu Ile Gly 
        195                 200                 205             


Thr Ile Lys Leu Phe Tyr Ser Ala Lys Asn Thr Ser Glu Leu Leu Phe 
    210                 215                 220                 


Lys Lys Asn Ile Leu Asp Leu Val Asn Glu Phe Pro Glu Lys Ile Ala 
225                 230                 235                 240 


Cys Ser Leu His Val Thr Lys Gln Thr Thr Gln Ile Asn Ala Glu Leu 
                245                 250                 255     


Lys Pro Tyr Ile Thr Glu Gly Arg Ile Thr Glu Lys Glu Ile Arg Asp 
            260                 265                 270         


His Ile Ser Lys Glu Thr Leu Phe Tyr Ile Cys Gly Pro Pro Pro Met 
        275                 280                 285             


Thr Asp Phe Phe Ser Lys Gln Leu Glu Asn Asn His Val Pro Lys Glu 
    290                 295                 300                 


His Ile Cys Phe Glu Lys Trp Trp 
305                 310         


<210>  9896
<211>  312
<212>  PRT
<213>  Homo Sapiens

<400>  9896

Met Ala Cys Ala Ala Val Met Ile Pro Gly Leu Leu Arg Cys Ser Val 
1               5                   10                  15      


Gly Ala Ile Arg Ile Glu Ala Ala Ser Leu Arg Leu Thr Leu Ser Thr 
            20                  25                  30          


Leu Arg His Leu Thr Leu Thr Ser Ile Met Lys Ser Lys Arg Lys Thr 
        35                  40                  45              


Asp His Met Glu Arg Thr Ala Ser Val Leu Arg Arg Glu Ile Val Ser 
    50                  55                  60                  


Ala Ala Lys Val Cys Gly Ala Ala Ser Glu Ser Pro Ser Val Lys Ser 
65                  70                  75                  80  


Leu Arg Leu Leu Val Ala Asp Gln Asp Phe Ser Phe Lys Ala Gly Gln 
                85                  90                  95      


Trp Val Asp Phe Phe Ile Pro Gly Val Ser Val Val Gly Gly Phe Ser 
            100                 105                 110         


Ile Cys Ser Ser Pro Arg Leu Leu Glu Gln Glu Arg Val Ile Glu Leu 
        115                 120                 125             


Ala Val Lys Tyr Thr Asn His Pro Pro Ala Leu Trp Val His Asn Thr 
    130                 135                 140                 


Cys Thr Leu Asp Cys Glu Val Ala Val Arg Val Gly Gly Glu Phe Phe 
145                 150                 155                 160 


Phe Asp Pro Gln Pro Ala Asp Ala Ser Arg Asn Leu Val Leu Ile Ala 
                165                 170                 175     


Gly Gly Val Gly Ile Asn Pro Leu Leu Ser Ile Leu Arg His Ala Ala 
            180                 185                 190         


Asp Leu Leu Arg Glu Gln Ala Asn Lys Arg Asn Gly Tyr Glu Ile Gly 
        195                 200                 205             


Thr Ile Lys Leu Phe Tyr Ser Ala Lys Asn Thr Ser Glu Leu Leu Phe 
    210                 215                 220                 


Lys Lys Asn Ile Leu Asp Leu Val Asn Glu Phe Pro Glu Lys Ile Ala 
225                 230                 235                 240 


Cys Ser Leu His Val Thr Lys Gln Thr Thr Gln Ile Asn Ala Glu Leu 
                245                 250                 255     


Lys Pro Tyr Ile Thr Glu Gly Arg Ile Thr Glu Lys Glu Ile Arg Asp 
            260                 265                 270         


His Ile Ser Lys Glu Thr Leu Phe Tyr Ile Cys Gly Pro Pro Pro Met 
        275                 280                 285             


Thr Asp Phe Phe Ser Lys Gln Leu Glu Asn Asn His Val Pro Lys Glu 
    290                 295                 300                 


His Ile Cys Phe Glu Lys Trp Trp 
305                 310         


<210>  9897
<211>  311
<212>  PRT
<213>  Homo Sapiens

<400>  9897

Met Ala Cys Ala Ala Val Met Ile Pro Gly Leu Leu Arg Cys Ser Val 
1               5                   10                  15      


Gly Ala Ile Arg Ile Glu Ala Ala Ser Leu Arg Leu Thr Leu Ser Thr 
            20                  25                  30          


Leu Arg His Leu Thr Leu Thr Ser Ile Met Lys Ser Lys Arg Lys Thr 
        35                  40                  45              


Asp His Met Glu Arg Thr Ala Ser Val Leu Arg Arg Glu Ile Val Ser 
    50                  55                  60                  


Ala Ala Lys Val Cys Gly Ala Ala Ser Glu Ser Pro Ser Val Lys Ser 
65                  70                  75                  80  


Leu Arg Leu Leu Val Ala Asp Gln Asp Phe Ser Phe Lys Ala Gly Gln 
                85                  90                  95      


Trp Val Asp Phe Phe Ile Pro Gly Val Ser Val Val Gly Gly Phe Ser 
            100                 105                 110         


Ile Cys Ser Ser Pro Arg Leu Leu Glu Gln Glu Arg Val Ile Glu Leu 
        115                 120                 125             


Ala Val Lys Tyr Thr Asn His Pro Pro Ala Leu Trp Val His Asn Thr 
    130                 135                 140                 


Cys Thr Leu Asp Cys Glu Val Ala Val Arg Val Gly Gly Glu Phe Phe 
145                 150                 155                 160 


Phe Asp Pro Gln Pro Ala Asp Ala Ser Arg Asn Leu Val Leu Ile Ala 
                165                 170                 175     


Gly Gly Val Gly Ile Asn Pro Leu Leu Ser Ile Leu Arg His Ala Ala 
            180                 185                 190         


Asp Leu Leu Arg Glu Gln Ala Asn Lys Arg Asn Gly Tyr Glu Ile Gly 
        195                 200                 205             


Thr Ile Lys Leu Phe Tyr Ser Ala Lys Asn Thr Ser Glu Leu Leu Phe 
    210                 215                 220                 


Lys Lys Asn Ile Leu Asp Leu Val Asn Glu Phe Pro Glu Lys Ile Ala 
225                 230                 235                 240 


Cys Ser Leu His Val Thr Lys Gln Thr Thr Gln Ile Asn Ala Glu Leu 
                245                 250                 255     


Lys Pro Tyr Ile Thr Gly Arg Ile Thr Glu Lys Glu Ile Arg Asp His 
            260                 265                 270         


Ile Ser Lys Glu Thr Leu Phe Tyr Ile Cys Gly Pro Pro Pro Met Thr 
        275                 280                 285             


Asp Phe Phe Ser Lys Gln Leu Glu Asn Asn His Val Pro Lys Glu His 
    290                 295                 300                 


Ile Cys Phe Glu Lys Trp Trp 
305                 310     


<210>  9898
<211>  71
<212>  PRT
<213>  Homo Sapiens

<400>  9898

Met Ala Cys Ala Ala Val Met Ile Pro Gly Leu Leu Arg Cys Ser Val 
1               5                   10                  15      


Gly Ala Ile Arg Ile Glu Ala Ala Ser Leu Arg Leu Thr Leu Ser Thr 
            20                  25                  30          


Leu Arg His Leu Thr Leu Thr Ser Ile Met Lys Ser Lys Arg Lys Thr 
        35                  40                  45              


Asp His Met Glu Arg Thr Ala Ser Val Leu Arg Arg Glu Ser Asn Leu 
    50                  55                  60                  


Phe His Gln Gly Arg Lys His 
65                  70      


<210>  9899
<211>  330
<212>  PRT
<213>  Homo Sapiens

<400>  9899

Met Thr Pro Lys Ile Ser Trp Thr Ser Lys Phe Ser Val Cys Pro Glu 
1               5                   10                  15      


Ser Ala Met Ala Cys Ala Ala Val Met Ile Pro Gly Leu Leu Arg Cys 
            20                  25                  30          


Ser Val Gly Ala Ile Arg Ile Glu Ala Ala Ser Leu Arg Leu Thr Leu 
        35                  40                  45              


Ser Thr Leu Arg His Leu Thr Leu Thr Ser Ile Met Lys Ser Lys Arg 
    50                  55                  60                  


Lys Thr Asp His Met Glu Arg Thr Ala Ser Val Leu Arg Arg Glu Ile 
65                  70                  75                  80  


Val Ser Ala Ala Lys Val Cys Gly Ala Ala Ser Glu Ser Pro Ser Val 
                85                  90                  95      


Lys Ser Leu Arg Leu Leu Val Ala Asp Gln Asp Phe Ser Phe Lys Ala 
            100                 105                 110         


Gly Gln Trp Val Asp Phe Phe Ile Pro Gly Val Ser Val Val Gly Gly 
        115                 120                 125             


Phe Ser Ile Cys Ser Ser Pro Arg Leu Leu Glu Gln Glu Arg Val Ile 
    130                 135                 140                 


Glu Leu Ala Val Lys Tyr Thr Asn His Pro Pro Ala Leu Trp Val His 
145                 150                 155                 160 


Asn Thr Cys Thr Leu Asp Cys Glu Val Ala Val Arg Val Gly Gly Glu 
                165                 170                 175     


Phe Phe Phe Asp Pro Gln Pro Ala Asp Ala Ser Arg Asn Leu Val Leu 
            180                 185                 190         


Ile Ala Gly Gly Val Gly Ile Asn Pro Leu Leu Ser Ile Leu Arg His 
        195                 200                 205             


Ala Ala Asp Leu Leu Arg Glu Gln Ala Asn Lys Arg Asn Gly Tyr Glu 
    210                 215                 220                 


Ile Gly Thr Ile Lys Leu Phe Tyr Ser Ala Lys Asn Thr Ser Glu Leu 
225                 230                 235                 240 


Leu Phe Lys Lys Asn Ile Leu Asp Leu Val Asn Glu Phe Pro Glu Lys 
                245                 250                 255     


Ile Ala Cys Ser Leu His Val Thr Lys Gln Thr Thr Gln Ile Asn Ala 
            260                 265                 270         


Glu Leu Lys Pro Tyr Ile Thr Glu Gly Arg Ile Thr Glu Lys Glu Ile 
        275                 280                 285             


Arg Asp His Ile Ser Lys Glu Thr Leu Phe Tyr Ile Cys Gly Pro Pro 
    290                 295                 300                 


Pro Met Thr Asp Phe Phe Ser Lys Gln Leu Glu Asn Asn His Val Pro 
305                 310                 315                 320 


Lys Glu His Ile Cys Phe Glu Lys Trp Trp 
                325                 330 


<210>  9900
<211>  330
<212>  PRT
<213>  Homo Sapiens

<400>  9900

Met Thr Pro Lys Ile Ser Trp Thr Ser Lys Phe Ser Val Cys Pro Glu 
1               5                   10                  15      


Ser Ala Met Ala Cys Ala Ala Val Met Ile Pro Gly Leu Leu Arg Cys 
            20                  25                  30          


Ser Val Gly Ala Ile Arg Ile Glu Ala Ala Ser Leu Arg Leu Thr Leu 
        35                  40                  45              


Ser Thr Leu Arg His Leu Thr Leu Thr Ser Ile Met Lys Ser Lys Arg 
    50                  55                  60                  


Lys Thr Asp His Met Glu Arg Thr Ala Ser Val Leu Arg Arg Glu Ile 
65                  70                  75                  80  


Val Ser Ala Ala Lys Val Cys Gly Ala Ala Ser Glu Ser Pro Ser Val 
                85                  90                  95      


Lys Ser Leu Arg Leu Leu Val Ala Asp Gln Asp Phe Ser Phe Lys Ala 
            100                 105                 110         


Gly Gln Trp Val Asp Phe Phe Ile Pro Gly Val Ser Val Val Gly Gly 
        115                 120                 125             


Phe Ser Ile Cys Ser Ser Pro Arg Leu Leu Glu Gln Glu Arg Val Ile 
    130                 135                 140                 


Glu Leu Ala Val Lys Tyr Thr Asn His Pro Pro Ala Leu Trp Val His 
145                 150                 155                 160 


Asn Thr Cys Thr Leu Asp Cys Glu Val Ala Val Arg Val Gly Gly Glu 
                165                 170                 175     


Phe Phe Phe Asp Pro Gln Pro Ala Asp Ala Ser Arg Asn Leu Val Leu 
            180                 185                 190         


Ile Ala Gly Gly Val Gly Ile Asn Pro Leu Leu Ser Ile Leu Arg His 
        195                 200                 205             


Ala Ala Asp Leu Leu Arg Glu Gln Ala Asn Lys Arg Asn Gly Tyr Glu 
    210                 215                 220                 


Ile Gly Thr Ile Lys Leu Phe Tyr Ser Ala Lys Asn Thr Ser Glu Leu 
225                 230                 235                 240 


Leu Phe Lys Lys Asn Ile Leu Asp Leu Val Asn Glu Phe Pro Glu Lys 
                245                 250                 255     


Ile Ala Cys Ser Leu His Val Thr Lys Gln Thr Thr Gln Ile Asn Ala 
            260                 265                 270         


Glu Leu Lys Pro Tyr Ile Thr Glu Gly Arg Ile Thr Glu Lys Glu Ile 
        275                 280                 285             


Arg Asp His Ile Ser Lys Glu Thr Leu Phe Tyr Ile Cys Gly Pro Pro 
    290                 295                 300                 


Pro Met Thr Asp Phe Phe Ser Lys Gln Leu Glu Asn Asn His Val Pro 
305                 310                 315                 320 


Lys Glu His Ile Cys Phe Glu Lys Trp Trp 
                325                 330 


<210>  9901
<211>  125
<212>  PRT
<213>  Homo Sapiens

<400>  9901

Met Ala Gly Pro Ser Leu Ala Cys Cys Leu Leu Gly Leu Leu Ala Leu 
1               5                   10                  15      


Thr Ser Ala Cys Tyr Ile Gln Asn Cys Pro Leu Gly Gly Lys Arg Ala 
            20                  25                  30          


Ala Pro Asp Leu Asp Val Arg Lys Cys Leu Pro Cys Gly Pro Gly Gly 
        35                  40                  45              


Lys Gly Arg Cys Phe Gly Pro Asn Ile Cys Cys Ala Glu Glu Leu Gly 
    50                  55                  60                  


Cys Phe Val Gly Thr Ala Glu Ala Leu Arg Cys Gln Glu Glu Asn Tyr 
65                  70                  75                  80  


Leu Pro Ser Pro Cys Gln Ser Gly Gln Lys Ala Cys Gly Ser Gly Gly 
                85                  90                  95      


Arg Cys Ala Val Leu Gly Leu Cys Cys Ser Pro Asp Gly Cys His Ala 
            100                 105                 110         


Asp Pro Ala Cys Asp Ala Glu Ala Thr Phe Ser Gln Arg 
        115                 120                 125 


<210>  9902
<211>  207
<212>  PRT
<213>  Homo Sapiens

<400>  9902

Met Ala Val Arg Ala Leu Lys Leu Leu Thr Thr Leu Leu Ala Val Val 
1               5                   10                  15      


Ala Ala Ala Ser Gln Ala Glu Val Glu Ser Glu Ala Gly Trp Gly Met 
            20                  25                  30          


Val Thr Pro Asp Leu Leu Phe Ala Glu Gly Thr Ala Ala Tyr Ala Arg 
        35                  40                  45              


Gly Asp Trp Pro Gly Val Val Leu Ser Met Glu Arg Ala Leu Arg Ser 
    50                  55                  60                  


Arg Ala Ala Leu Arg Ala Leu Arg Leu Arg Cys Arg Thr Gln Cys Ala 
65                  70                  75                  80  


Ala Asp Phe Pro Trp Glu Leu Asp Pro Asp Trp Ser Pro Ser Pro Ala 
                85                  90                  95      


Gln Ala Ser Gly Ala Ala Ala Leu Arg Asp Leu Ser Phe Phe Gly Gly 
            100                 105                 110         


Leu Leu Arg Arg Ala Ala Cys Leu Arg Arg Cys Leu Gly Pro Pro Ala 
        115                 120                 125             


Ala His Ser Leu Ser Glu Glu Met Glu Leu Glu Phe Arg Lys Arg Ser 
    130                 135                 140                 


Pro Tyr Asn Tyr Leu Gln Val Ala Tyr Phe Lys Asp Leu Glu Thr Gln 
145                 150                 155                 160 


Pro His Met Gln Glu Phe Arg Leu Gly Val Arg Leu Tyr Ser Glu Glu 
                165                 170                 175     


Gln Pro Gln Glu Ala Val Pro His Leu Glu Ala Ala Leu Gln Glu Tyr 
            180                 185                 190         


Phe Val Ala Tyr Glu Glu Cys Arg Ala Leu Cys Glu Gly Pro Tyr 
        195                 200                 205         


<210>  9903
<211>  804
<212>  PRT
<213>  Homo Sapiens

<400>  9903

Met Ala Val Arg Ala Leu Lys Leu Leu Thr Thr Leu Leu Ala Val Val 
1               5                   10                  15      


Ala Ala Ala Ser Gln Ala Glu Val Glu Ser Glu Ala Gly Trp Gly Met 
            20                  25                  30          


Val Thr Pro Asp Leu Leu Phe Ala Glu Gly Thr Ala Ala Tyr Ala Arg 
        35                  40                  45              


Gly Asp Trp Pro Gly Val Val Leu Ser Met Glu Arg Ala Leu Arg Ser 
    50                  55                  60                  


Arg Ala Ala Leu Arg Ala Leu Arg Leu Arg Cys Arg Thr Gln Cys Ala 
65                  70                  75                  80  


Ala Asp Phe Pro Trp Glu Leu Asp Pro Asp Trp Ser Pro Ser Pro Ala 
                85                  90                  95      


Gln Ala Ser Gly Ala Ala Ala Leu Arg Asp Leu Ser Phe Phe Gly Gly 
            100                 105                 110         


Leu Leu Arg Arg Ala Ala Cys Leu Arg Arg Cys Leu Gly Pro Pro Ala 
        115                 120                 125             


Ala His Ser Leu Ser Glu Glu Met Glu Leu Glu Phe Arg Lys Arg Ser 
    130                 135                 140                 


Pro Tyr Asn Tyr Leu Gln Val Ala Tyr Phe Lys Ile Asn Lys Leu Glu 
145                 150                 155                 160 


Lys Ala Val Ala Ala Ala His Thr Phe Phe Val Gly Asn Pro Glu His 
                165                 170                 175     


Met Glu Met Gln Gln Asn Leu Asp Tyr Tyr Gln Thr Met Ser Gly Val 
            180                 185                 190         


Lys Glu Ala Asp Phe Lys Asp Leu Glu Thr Gln Pro His Met Gln Glu 
        195                 200                 205             


Phe Arg Leu Gly Val Arg Leu Tyr Ser Glu Glu Gln Pro Gln Glu Ala 
    210                 215                 220                 


Val Pro His Leu Glu Ala Ala Leu Gln Glu Tyr Phe Val Ala Tyr Glu 
225                 230                 235                 240 


Glu Cys Arg Ala Leu Cys Glu Gly Pro Tyr Asp Tyr Asp Gly Tyr Asn 
                245                 250                 255     


Tyr Leu Glu Tyr Asn Ala Asp Leu Phe Gln Ala Ile Thr Asp His Tyr 
            260                 265                 270         


Ile Gln Val Leu Asn Cys Lys Gln Asn Cys Val Thr Glu Leu Ala Ser 
        275                 280                 285             


His Pro Ser Arg Glu Lys Pro Phe Glu Asp Phe Leu Pro Ser His Tyr 
    290                 295                 300                 


Asn Tyr Leu Gln Phe Ala Tyr Tyr Asn Ile Gly Asn Tyr Thr Gln Ala 
305                 310                 315                 320 


Val Glu Cys Ala Lys Thr Tyr Leu Leu Phe Phe Pro Asn Asp Glu Val 
                325                 330                 335     


Met Asn Gln Asn Leu Ala Tyr Tyr Ala Ala Met Leu Gly Glu Glu His 
            340                 345                 350         


Thr Arg Ser Ile Gly Pro Arg Glu Ser Ala Lys Glu Tyr Arg Gln Arg 
        355                 360                 365             


Ser Leu Leu Glu Lys Glu Leu Leu Phe Phe Ala Tyr Asp Val Phe Gly 
    370                 375                 380                 


Ile Pro Phe Val Asp Pro Asp Ser Trp Thr Pro Glu Glu Val Ile Pro 
385                 390                 395                 400 


Lys Arg Leu Gln Glu Lys Gln Lys Ser Glu Arg Glu Thr Ala Val Arg 
                405                 410                 415     


Ile Ser Gln Glu Ile Gly Asn Leu Met Lys Glu Ile Glu Thr Leu Val 
            420                 425                 430         


Glu Glu Lys Thr Lys Glu Ser Leu Asp Val Ser Arg Leu Thr Arg Glu 
        435                 440                 445             


Gly Gly Pro Leu Leu Tyr Glu Gly Ile Ser Leu Thr Met Asn Ser Lys 
    450                 455                 460                 


Leu Leu Asn Gly Ser Gln Arg Val Val Met Asp Gly Val Ile Ser Asp 
465                 470                 475                 480 


His Glu Cys Gln Glu Leu Gln Arg Leu Thr Asn Val Ala Ala Thr Ser 
                485                 490                 495     


Gly Asp Gly Tyr Arg Gly Gln Thr Ser Pro His Thr Pro Asn Glu Lys 
            500                 505                 510         


Phe Tyr Gly Val Thr Val Phe Lys Ala Leu Lys Leu Gly Gln Glu Gly 
        515                 520                 525             


Lys Val Pro Leu Gln Ser Ala His Leu Tyr Tyr Asn Val Thr Glu Lys 
    530                 535                 540                 


Val Arg Arg Ile Met Glu Ser Tyr Phe Arg Leu Asp Thr Pro Leu Tyr 
545                 550                 555                 560 


Phe Ser Tyr Ser His Leu Val Cys Arg Thr Ala Ile Glu Glu Val Gln 
                565                 570                 575     


Ala Glu Arg Lys Asp Asp Ser His Pro Val His Val Asp Asn Cys Ile 
            580                 585                 590         


Leu Asn Ala Glu Thr Leu Val Cys Val Lys Glu Pro Pro Ala Tyr Thr 
        595                 600                 605             


Phe Arg Asp Tyr Ser Ala Ile Leu Tyr Leu Asn Gly Asp Phe Asp Gly 
    610                 615                 620                 


Gly Asn Phe Tyr Phe Thr Glu Leu Asp Ala Lys Thr Val Thr Ala Glu 
625                 630                 635                 640 


Val Gln Pro Gln Cys Gly Arg Ala Val Gly Phe Ser Ser Gly Thr Glu 
                645                 650                 655     


Asn Pro His Gly Val Lys Ala Val Thr Arg Gly Gln Arg Cys Ala Ile 
            660                 665                 670         


Ala Leu Trp Phe Thr Leu Asp Pro Arg His Ser Glu Arg Val Arg Ala 
        675                 680                 685             


Ala Arg Ala Gly Glu Ser Ser Trp Cys Cys Gly Asp Pro Phe Pro Glu 
    690                 695                 700                 


Arg Pro Trp Phe Ala Phe Leu Phe Pro Lys Ser His Cys Gln Trp Leu 
705                 710                 715                 720 


Arg His Glu Arg Ser Thr Trp Asp Thr Ser Ser Asn Ala Leu Ser Leu 
                725                 730                 735     


Trp Ser His Cys Leu Val Leu Pro Gly Pro Ala Val Asn Gly Ile Gln 
            740                 745                 750         


Val Gly Lys Glu Val Lys Thr Gly Ser Asp Ala Glu Phe Leu Val Pro 
        755                 760                 765             


Ser Leu Gly Pro Thr Ser Ala Val Leu Phe Gln Arg Val Gly Pro Ala 
    770                 775                 780                 


Gly Lys Glu Met Ser Leu Gly Pro Leu Arg Asn Leu Pro Cys Pro Leu 
785                 790                 795                 800 


Gly Ser Ser Ser 
                


<210>  9904
<211>  736
<212>  PRT
<213>  Homo Sapiens

<400>  9904

Met Ala Val Arg Ala Leu Lys Leu Leu Thr Thr Leu Leu Ala Val Val 
1               5                   10                  15      


Ala Ala Ala Ser Gln Ala Glu Val Glu Ser Glu Ala Gly Trp Gly Met 
            20                  25                  30          


Val Thr Pro Asp Leu Leu Phe Ala Glu Gly Thr Ala Ala Tyr Ala Arg 
        35                  40                  45              


Gly Asp Trp Pro Gly Val Val Leu Ser Met Glu Arg Ala Leu Arg Ser 
    50                  55                  60                  


Arg Ala Ala Leu Arg Ala Leu Arg Leu Arg Cys Arg Thr Gln Cys Ala 
65                  70                  75                  80  


Ala Asp Phe Pro Trp Glu Leu Asp Pro Asp Trp Ser Pro Ser Pro Ala 
                85                  90                  95      


Gln Ala Ser Gly Ala Ala Ala Leu Arg Asp Leu Ser Phe Phe Gly Gly 
            100                 105                 110         


Leu Leu Arg Arg Ala Ala Cys Leu Arg Arg Cys Leu Gly Pro Pro Ala 
        115                 120                 125             


Ala His Ser Leu Ser Glu Glu Met Glu Leu Glu Phe Arg Lys Arg Ser 
    130                 135                 140                 


Pro Tyr Asn Tyr Leu Gln Val Ala Tyr Phe Lys Ile Asn Lys Leu Glu 
145                 150                 155                 160 


Lys Ala Val Ala Ala Ala His Thr Phe Phe Val Gly Asn Pro Glu His 
                165                 170                 175     


Met Glu Met Gln Gln Asn Leu Asp Tyr Tyr Gln Thr Met Ser Gly Val 
            180                 185                 190         


Lys Glu Ala Asp Phe Lys Asp Leu Glu Thr Gln Pro His Met Gln Glu 
        195                 200                 205             


Phe Arg Leu Gly Val Arg Leu Tyr Ser Glu Glu Gln Pro Gln Glu Ala 
    210                 215                 220                 


Val Pro His Leu Glu Ala Ala Leu Gln Glu Tyr Phe Val Ala Tyr Glu 
225                 230                 235                 240 


Glu Cys Arg Ala Leu Cys Glu Gly Pro Tyr Asp Tyr Asp Gly Tyr Asn 
                245                 250                 255     


Tyr Leu Glu Tyr Asn Ala Asp Leu Phe Gln Ala Ile Thr Asp His Tyr 
            260                 265                 270         


Ile Gln Val Leu Asn Cys Lys Gln Asn Cys Val Thr Glu Leu Ala Ser 
        275                 280                 285             


His Pro Ser Arg Glu Lys Pro Phe Glu Asp Phe Leu Pro Ser His Tyr 
    290                 295                 300                 


Asn Tyr Leu Gln Phe Ala Tyr Tyr Asn Ile Gly Asn Tyr Thr Gln Ala 
305                 310                 315                 320 


Val Glu Cys Ala Lys Thr Tyr Leu Leu Phe Phe Pro Asn Asp Glu Val 
                325                 330                 335     


Met Asn Gln Asn Leu Ala Tyr Tyr Ala Ala Met Leu Gly Glu Glu His 
            340                 345                 350         


Thr Arg Ser Ile Gly Pro Arg Glu Ser Ala Lys Glu Tyr Arg Gln Arg 
        355                 360                 365             


Ser Leu Leu Glu Lys Glu Leu Leu Phe Phe Ala Tyr Asp Val Phe Gly 
    370                 375                 380                 


Ile Pro Phe Val Asp Pro Asp Ser Trp Thr Pro Glu Glu Val Ile Pro 
385                 390                 395                 400 


Lys Arg Leu Gln Glu Lys Gln Lys Ser Glu Arg Glu Thr Ala Val Arg 
                405                 410                 415     


Ile Ser Gln Glu Ile Gly Asn Leu Met Lys Glu Ile Glu Thr Leu Val 
            420                 425                 430         


Glu Glu Lys Thr Lys Glu Ser Leu Asp Val Ser Arg Leu Thr Arg Glu 
        435                 440                 445             


Gly Gly Pro Leu Leu Tyr Glu Gly Ile Ser Leu Thr Met Asn Ser Lys 
    450                 455                 460                 


Leu Leu Asn Gly Ser Gln Arg Val Val Met Asp Gly Val Ile Ser Asp 
465                 470                 475                 480 


His Glu Cys Gln Glu Leu Gln Arg Leu Thr Asn Val Ala Ala Thr Ser 
                485                 490                 495     


Gly Asp Gly Tyr Arg Gly Gln Thr Ser Pro His Thr Pro Asn Glu Lys 
            500                 505                 510         


Phe Tyr Gly Val Thr Val Phe Lys Ala Leu Lys Leu Gly Gln Glu Gly 
        515                 520                 525             


Lys Val Pro Leu Gln Ser Ala His Leu Tyr Tyr Asn Val Thr Glu Lys 
    530                 535                 540                 


Val Arg Arg Ile Met Glu Ser Tyr Phe Arg Leu Asp Thr Pro Leu Tyr 
545                 550                 555                 560 


Phe Ser Tyr Ser His Leu Val Cys Arg Thr Ala Ile Glu Glu Val Gln 
                565                 570                 575     


Ala Glu Arg Lys Asp Asp Ser His Pro Val His Val Asp Asn Cys Ile 
            580                 585                 590         


Leu Asn Ala Glu Thr Leu Val Cys Val Lys Glu Pro Pro Ala Tyr Thr 
        595                 600                 605             


Phe Arg Asp Tyr Ser Ala Ile Leu Tyr Leu Asn Gly Asp Phe Asp Gly 
    610                 615                 620                 


Gly Asn Phe Tyr Phe Thr Glu Leu Asp Ala Lys Thr Val Thr Ala Glu 
625                 630                 635                 640 


Val Gln Pro Gln Cys Gly Arg Ala Val Gly Phe Ser Ser Gly Thr Glu 
                645                 650                 655     


Asn Pro His Gly Val Lys Ala Val Thr Arg Gly Gln Arg Cys Ala Ile 
            660                 665                 670         


Ala Leu Trp Phe Thr Leu Asp Pro Arg His Ser Glu Arg Asp Arg Val 
        675                 680                 685             


Gln Ala Asp Asp Leu Val Lys Met Leu Phe Ser Pro Glu Glu Met Asp 
    690                 695                 700                 


Leu Ser Gln Glu Gln Pro Leu Asp Ala Gln Gln Gly Pro Pro Glu Pro 
705                 710                 715                 720 


Ala Gln Glu Ser Leu Ser Gly Ser Glu Ser Lys Pro Lys Asp Glu Leu 
                725                 730                 735     


<210>  9905
<211>  697
<212>  PRT
<213>  Homo Sapiens

<400>  9905

Met Ala Val Arg Ala Leu Lys Leu Leu Thr Thr Leu Leu Ala Val Val 
1               5                   10                  15      


Ala Ala Ala Ser Gln Ala Glu Val Glu Ser Glu Ala Gly Trp Gly Met 
            20                  25                  30          


Val Thr Pro Asp Leu Leu Phe Ala Glu Gly Thr Ala Ala Tyr Ala Arg 
        35                  40                  45              


Gly Asp Trp Pro Gly Val Val Leu Ser Met Glu Arg Ala Leu Arg Ser 
    50                  55                  60                  


Arg Ala Ala Leu Arg Ala Leu Arg Leu Arg Cys Arg Thr Gln Cys Ala 
65                  70                  75                  80  


Ala Asp Phe Pro Trp Glu Leu Asp Pro Asp Trp Ser Pro Ser Pro Ala 
                85                  90                  95      


Gln Ala Ser Gly Ala Ala Ala Leu Arg Asp Leu Ser Phe Phe Gly Gly 
            100                 105                 110         


Leu Leu Arg Arg Ala Ala Cys Leu Arg Arg Cys Leu Gly Pro Pro Ala 
        115                 120                 125             


Ala His Ser Leu Ser Glu Glu Met Glu Leu Glu Phe Arg Lys Arg Ser 
    130                 135                 140                 


Pro Tyr Asn Tyr Leu Gln Val Ala Tyr Phe Lys Ile Asn Lys Leu Glu 
145                 150                 155                 160 


Lys Ala Val Ala Ala Ala His Thr Phe Phe Val Gly Asn Pro Glu His 
                165                 170                 175     


Met Glu Met Gln Gln Asn Leu Asp Tyr Tyr Gln Thr Met Ser Gly Val 
            180                 185                 190         


Lys Glu Ala Asp Phe Lys Asp Leu Glu Thr Gln Pro His Met Gln Glu 
        195                 200                 205             


Phe Arg Leu Gly Val Arg Leu Tyr Ser Glu Glu Gln Pro Gln Glu Ala 
    210                 215                 220                 


Val Pro His Leu Glu Ala Ala Leu Gln Glu Tyr Phe Val Ala Tyr Glu 
225                 230                 235                 240 


Glu Cys Arg Ala Leu Cys Glu Gly Pro Tyr Asp Tyr Asp Gly Tyr Asn 
                245                 250                 255     


Tyr Leu Glu Tyr Asn Ala Asp Leu Phe Gln Ala Ile Thr Asp His Tyr 
            260                 265                 270         


Ile Gln Val Leu Asn Cys Lys Gln Asn Cys Val Thr Glu Leu Ala Ser 
        275                 280                 285             


His Pro Ser Arg Glu Lys Pro Phe Glu Asp Phe Leu Pro Ser His Tyr 
    290                 295                 300                 


Asn Tyr Leu Gln Phe Ala Tyr Tyr Asn Ile Gly Asn Tyr Thr Gln Ala 
305                 310                 315                 320 


Val Glu Cys Ala Lys Thr Tyr Leu Leu Phe Phe Pro Asn Asp Glu Val 
                325                 330                 335     


Met Asn Gln Asn Leu Ala Tyr Tyr Ala Ala Met Leu Gly Glu Glu His 
            340                 345                 350         


Thr Arg Ser Ile Gly Pro Arg Glu Ser Ala Lys Glu Tyr Arg Gln Arg 
        355                 360                 365             


Ser Leu Leu Glu Lys Glu Leu Leu Phe Phe Ala Tyr Asp Val Phe Gly 
    370                 375                 380                 


Ile Pro Phe Val Asp Pro Asp Ser Trp Thr Pro Glu Glu Val Ile Pro 
385                 390                 395                 400 


Lys Arg Leu Gln Glu Lys Gln Lys Ser Glu Arg Glu Thr Ala Val Arg 
                405                 410                 415     


Ile Ser Gln Glu Ile Gly Asn Leu Met Lys Glu Ile Glu Thr Leu Val 
            420                 425                 430         


Glu Glu Lys Thr Lys Glu Ser Leu Asp Val Ser Arg Leu Thr Arg Glu 
        435                 440                 445             


Gly Gly Pro Leu Leu Tyr Glu Gly Ile Ser Leu Thr Met Asn Ser Lys 
    450                 455                 460                 


Leu Leu Asn Gly Ser Gln Arg Val Val Met Asp Gly Val Ile Ser Asp 
465                 470                 475                 480 


His Glu Cys Gln Glu Leu Gln Arg Leu Thr Asn Val Ala Ala Thr Ser 
                485                 490                 495     


Gly Asp Gly Tyr Arg Gly Gln Thr Ser Pro His Thr Pro Asn Glu Lys 
            500                 505                 510         


Phe Tyr Gly Val Thr Val Phe Lys Ala Leu Lys Leu Gly Gln Glu Gly 
        515                 520                 525             


Lys Val Pro Leu Gln Ser Ala His Leu Tyr Tyr Asn Val Thr Glu Lys 
    530                 535                 540                 


Val Arg Arg Ile Met Glu Ser Tyr Phe Arg Leu Asp Thr Pro Leu Tyr 
545                 550                 555                 560 


Phe Ser Tyr Ser His Leu Val Cys Arg Thr Ala Ile Glu Glu Val Gln 
                565                 570                 575     


Ala Glu Arg Lys Asp Asp Ser His Pro Val His Val Asp Asn Cys Ile 
            580                 585                 590         


Leu Asn Ala Glu Thr Leu Val Cys Val Lys Glu Pro Pro Ala Tyr Thr 
        595                 600                 605             


Phe Arg Asp Tyr Ser Ala Ile Leu Tyr Leu Asn Gly Asp Phe Asp Gly 
    610                 615                 620                 


Gly Asn Phe Tyr Phe Thr Glu Leu Asp Ala Lys Thr Val Thr Ala Glu 
625                 630                 635                 640 


Val Gln Pro Gln Cys Gly Arg Ala Val Gly Phe Ser Ser Gly Thr Glu 
                645                 650                 655     


Asn Pro His Gly Val Lys Ala Val Thr Arg Gly Gln Arg Cys Ala Ile 
            660                 665                 670         


Ala Leu Trp Phe Thr Leu Asp Pro Arg His Ser Glu Arg Val Arg Ala 
        675                 680                 685             


Ala Arg Ala Gly Gln Gly Ala Gly Arg 
    690                 695         


<210>  9906
<211>  222
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9906

Xaa Thr Pro Glu Glu Val Ile Pro Lys Arg Leu Gln Glu Lys Gln Lys 
1               5                   10                  15      


Ser Glu Arg Glu Thr Ala Val Arg Ile Ser Gln Glu Ile Gly Asn Leu 
            20                  25                  30          


Met Lys Glu Ile Glu Thr Leu Val Glu Glu Lys Thr Lys Glu Ser Leu 
        35                  40                  45              


Asp Val Ser Arg Leu Thr Arg Glu Gly Gly Pro Leu Leu Tyr Glu Gly 
    50                  55                  60                  


Ile Ser Leu Thr Met Asn Ser Lys Leu Leu Asn Gly Ser Gln Arg Val 
65                  70                  75                  80  


Val Met Asp Gly Val Ile Ser Asp His Glu Cys Gln Glu Leu Gln Arg 
                85                  90                  95      


Leu Thr Asn Val Ala Ala Thr Ser Gly Asp Gly Tyr Arg Gly Gln Thr 
            100                 105                 110         


Ser Pro His Thr Pro Asn Glu Lys Phe Tyr Gly Val Thr Val Phe Lys 
        115                 120                 125             


Ala Leu Lys Phe His Val Ala Gly Glu Ala Ser Gln Ser Trp Trp Lys 
    130                 135                 140                 


Ala Lys Arg Ser Lys Ser His Leu Thr Trp Met Ala Ala Gly Lys Glu 
145                 150                 155                 160 


Arg Thr Ser Ala Ala Gly Ala Arg Arg Gln Ser Ser Ser Ala Glu Cys 
                165                 170                 175     


Pro Pro Val Leu Gln Arg Asp Gly Glu Gly Ala Ala His His Gly Val 
            180                 185                 190         


Leu Leu Pro Pro Gly Tyr Ala Pro Leu Leu Phe Leu Leu Ser Ser Gly 
        195                 200                 205             


Val Pro His Cys His Arg Arg Gly Pro Gly Arg Glu Glu Gly 
    210                 215                 220         


<210>  9907
<211>  134
<212>  PRT
<213>  Homo Sapiens

<400>  9907

Met Glu Met Gln Gln Asn Ile Glu Asn Tyr Arg Ala Thr Ala Gly Val 
1               5                   10                  15      


Glu Ala Leu Gln Leu Val Asp Arg Glu Ala Lys Pro His Met Glu Ser 
            20                  25                  30          


Tyr Asn Ala Gly Val Lys His Tyr Glu Ala Asp Asp Phe Glu Met Ala 
        35                  40                  45              


Ile Arg His Phe Glu Gln Ala Leu Arg Glu Tyr Phe Val Glu Asp Thr 
    50                  55                  60                  


Glu Cys Arg Thr Leu Cys Glu Gly Pro Gln Arg Phe Glu Glu Tyr Glu 
65                  70                  75                  80  


Tyr Leu Gly Tyr Lys Ala Gly Leu Tyr Glu Ala Ile Ala Asp His Tyr 
                85                  90                  95      


Met Gln Val Leu Val Cys Gln His Glu Cys Val Arg Glu Leu Ala Thr 
            100                 105                 110         


Arg Pro Gly Arg Leu Ser Pro Ile Glu Asn Phe Leu Pro Leu His Tyr 
        115                 120                 125             


Asp Tyr Leu Gln Phe Ala 
    130                 


<210>  9908
<211>  137
<212>  PRT
<213>  Homo Sapiens

<400>  9908

Met Glu Met Gln Gln Asn Ile Glu Asn Tyr Arg Ala Thr Ala Gly Val 
1               5                   10                  15      


Glu Ala Leu Gln Leu Val Asp Arg Glu Ala Lys Pro His Met Glu Ser 
            20                  25                  30          


Tyr Asn Ala Gly Val Lys His Tyr Glu Ala Asp Asp Phe Glu Met Ala 
        35                  40                  45              


Ile Arg His Phe Glu Gln Ala Leu Arg Glu Tyr Phe Val Glu Asp Thr 
    50                  55                  60                  


Glu Cys Arg Thr Leu Cys Glu Gly Pro Gln Arg Phe Glu Glu Tyr Glu 
65                  70                  75                  80  


Tyr Leu Gly Tyr Lys Ala Gly Leu Tyr Glu Ala Ile Ala Asp His Tyr 
                85                  90                  95      


Met Gln Val Leu Val Cys Gln His Glu Cys Val Arg Glu Leu Ala Thr 
            100                 105                 110         


Arg Pro Gly Arg Leu Ser Pro Ile Glu Asn Phe Leu Pro Leu His Tyr 
        115                 120                 125             


Asp Tyr Leu Gln Phe Ala Tyr Tyr Arg 
    130                 135         


<210>  9909
<211>  527
<212>  PRT
<213>  Homo Sapiens

<400>  9909

Met Glu Met Gln Gln Asn Ile Glu Asn Tyr Arg Ala Thr Ala Gly Val 
1               5                   10                  15      


Glu Ala Leu Gln Leu Val Asp Arg Glu Ala Lys Pro His Met Glu Ser 
            20                  25                  30          


Tyr Asn Ala Gly Val Lys His Tyr Glu Ala Asp Asp Phe Glu Met Ala 
        35                  40                  45              


Ile Arg His Phe Glu Gln Ala Leu Arg Glu Tyr Phe Val Glu Asp Thr 
    50                  55                  60                  


Glu Cys Arg Thr Leu Cys Glu Gly Pro Gln Arg Phe Glu Glu Tyr Glu 
65                  70                  75                  80  


Tyr Leu Gly Tyr Lys Ala Gly Leu Tyr Glu Ala Ile Ala Asp His Tyr 
                85                  90                  95      


Met Gln Val Leu Val Cys Gln His Glu Cys Val Arg Glu Leu Ala Thr 
            100                 105                 110         


Arg Pro Gly Arg Leu Ser Pro Ile Glu Asn Phe Leu Pro Leu His Tyr 
        115                 120                 125             


Asp Tyr Leu Gln Phe Ala Tyr Tyr Arg Val Gly Glu Tyr Val Lys Ala 
    130                 135                 140                 


Leu Glu Cys Ala Lys Ala Tyr Leu Leu Cys His Pro Asp Asp Glu Asp 
145                 150                 155                 160 


Val Leu Asp Asn Val Asp Tyr Tyr Glu Ser Leu Leu Asp Asp Ser Ile 
                165                 170                 175     


Asp Pro Ala Ser Ile Glu Ala Arg Glu Asp Leu Thr Met Phe Val Lys 
            180                 185                 190         


Arg His Lys Leu Glu Ser Glu Leu Ile Lys Ser Ala Ala Glu Gly Leu 
        195                 200                 205             


Gly Phe Ser Tyr Thr Glu Pro Asn Tyr Trp Ile Arg Tyr Gly Gly Arg 
    210                 215                 220                 


Gln Asp Glu Asn Arg Val Pro Ser Gly Val Asn Val Glu Gly Ala Glu 
225                 230                 235                 240 


Val His Gly Phe Ser Met Gly Lys Lys Leu Ser Pro Lys Ile Asp Arg 
                245                 250                 255     


Asp Leu Arg Glu Gly Gly Pro Leu Leu Tyr Glu Asn Ile Thr Phe Val 
            260                 265                 270         


Tyr Asn Ser Glu Gln Leu Asn Gly Thr Gln Arg Val Leu Leu Asp Asn 
        275                 280                 285             


Val Leu Ser Glu Glu Gln Cys Arg Glu Leu His Ser Val Ala Ser Gly 
    290                 295                 300                 


Ile Met Leu Val Gly Asp Gly Tyr Arg Gly Lys Thr Ser Pro His Thr 
305                 310                 315                 320 


Pro Asn Glu Lys Phe Glu Gly Ala Thr Val Leu Lys Ala Leu Lys Ser 
                325                 330                 335     


Gly Tyr Glu Gly Arg Val Pro Leu Lys Ser Ala Arg Leu Phe Tyr Asp 
            340                 345                 350         


Ile Ser Glu Lys Ala Arg Arg Ile Val Glu Ser Tyr Phe Met Leu Asn 
        355                 360                 365             


Ser Thr Leu Tyr Phe Ser Tyr Thr His Met Val Cys Arg Thr Ala Leu 
    370                 375                 380                 


Ser Gly Gln Gln Asp Arg Arg Asn Asp Leu Ser His Pro Ile His Ala 
385                 390                 395                 400 


Asp Asn Cys Leu Leu Asp Pro Glu Ala Asn Glu Cys Trp Lys Glu Pro 
                405                 410                 415     


Pro Ala Tyr Thr Phe Arg Asp Tyr Ser Ala Leu Leu Tyr Met Asn Asp 
            420                 425                 430         


Asp Phe Glu Gly Gly Glu Phe Ile Phe Thr Glu Met Asp Ala Lys Thr 
        435                 440                 445             


Val Thr Ala Ser Ile Lys Pro Lys Cys Gly Arg Met Ile Ser Phe Ser 
    450                 455                 460                 


Ser Gly Gly Glu Asn Pro His Gly Val Lys Ala Val Thr Lys Gly Lys 
465                 470                 475                 480 


Arg Cys Ala Val Ala Leu Trp Phe Thr Leu Asp Pro Leu Tyr Arg Glu 
                485                 490                 495     


Leu Glu Arg Ile Gln Ala Asp Glu Val Ile Ala Ile Leu Asp Gln Glu 
            500                 505                 510         


Gln Gln Gly Lys His Glu Leu Asn Ile Asn Pro Lys Asp Glu Leu 
        515                 520                 525         


<210>  9910
<211>  708
<212>  PRT
<213>  Homo Sapiens

<400>  9910

Met Arg Glu Arg Ile Trp Ala Pro Pro Leu Leu Leu Leu Leu Pro Leu 
1               5                   10                  15      


Leu Leu Pro Pro Pro Leu Trp Gly Gly Pro Pro Asp Ser Pro Arg Arg 
            20                  25                  30          


Glu Leu Glu Leu Glu Pro Gly Pro Leu Gln Pro Phe Asp Leu Leu Tyr 
        35                  40                  45              


Ala Ser Gly Ala Ala Ala Tyr Tyr Ser Gly Asp Tyr Glu Arg Ala Val 
    50                  55                  60                  


Arg Asp Leu Glu Ala Ala Leu Arg Ser His Arg Arg Leu Arg Glu Ile 
65                  70                  75                  80  


Arg Thr Arg Cys Ala Arg His Cys Ala Ala Arg His Pro Leu Pro Pro 
                85                  90                  95      


Pro Pro Pro Gly Glu Gly Pro Gly Ala Glu Leu Pro Leu Phe Arg Ser 
            100                 105                 110         


Leu Leu Gly Arg Ala Arg Cys Tyr Arg Ser Cys Glu Thr Gln Arg Leu 
        115                 120                 125             


Gly Gly Pro Ala Ser Arg His Arg Val Ser Glu Asp Val Arg Ser Asp 
    130                 135                 140                 


Phe Gln Arg Arg Val Pro Tyr Asn Tyr Leu Gln Arg Ala Tyr Ile Lys 
145                 150                 155                 160 


Leu Asn Gln Leu Glu Lys Ala Val Glu Ala Ala His Thr Phe Phe Val 
                165                 170                 175     


Ala Asn Pro Glu His Met Glu Met Gln Gln Asn Ile Glu Asn Tyr Arg 
            180                 185                 190         


Ala Thr Ala Gly Val Glu Ala Leu Gln Leu Val Asp Arg Glu Ala Lys 
        195                 200                 205             


Pro His Met Glu Ser Tyr Asn Ala Gly Val Lys His Tyr Glu Ala Asp 
    210                 215                 220                 


Asp Phe Glu Met Ala Ile Arg His Phe Glu Gln Ala Leu Arg Glu Tyr 
225                 230                 235                 240 


Phe Val Glu Asp Thr Glu Cys Arg Thr Leu Cys Glu Gly Pro Gln Arg 
                245                 250                 255     


Phe Glu Glu Tyr Glu Tyr Leu Gly Tyr Lys Ala Gly Leu Tyr Glu Ala 
            260                 265                 270         


Ile Ala Asp His Tyr Met Gln Val Leu Val Cys Gln His Glu Cys Val 
        275                 280                 285             


Arg Glu Leu Ala Thr Arg Pro Gly Arg Leu Ser Pro Ile Glu Asn Phe 
    290                 295                 300                 


Leu Pro Leu His Tyr Asp Tyr Leu Gln Phe Ala Tyr Tyr Arg Val Gly 
305                 310                 315                 320 


Glu Tyr Val Lys Ala Leu Glu Cys Ala Lys Ala Tyr Leu Leu Cys His 
                325                 330                 335     


Pro Asp Asp Glu Asp Val Leu Asp Asn Val Asp Tyr Tyr Glu Ser Leu 
            340                 345                 350         


Leu Asp Asp Ser Ile Asp Pro Ala Ser Ile Glu Ala Arg Glu Asp Leu 
        355                 360                 365             


Thr Met Phe Val Lys Arg His Lys Leu Glu Ser Glu Leu Ile Lys Ser 
    370                 375                 380                 


Ala Ala Glu Gly Leu Gly Phe Ser Tyr Thr Glu Pro Asn Tyr Trp Ile 
385                 390                 395                 400 


Arg Tyr Gly Gly Arg Gln Asp Glu Asn Arg Val Pro Ser Gly Val Asn 
                405                 410                 415     


Val Glu Gly Ala Glu Val His Gly Phe Ser Met Gly Lys Lys Leu Ser 
            420                 425                 430         


Pro Lys Ile Asp Arg Asp Leu Arg Glu Gly Gly Pro Leu Leu Tyr Glu 
        435                 440                 445             


Asn Ile Thr Phe Val Tyr Asn Ser Glu Gln Leu Asn Gly Thr Gln Arg 
    450                 455                 460                 


Val Leu Leu Asp Asn Val Leu Ser Glu Glu Gln Cys Arg Glu Leu His 
465                 470                 475                 480 


Ser Val Ala Ser Gly Ile Met Leu Val Gly Asp Gly Tyr Arg Gly Lys 
                485                 490                 495     


Thr Ser Pro His Thr Pro Asn Glu Lys Phe Glu Gly Ala Thr Val Leu 
            500                 505                 510         


Lys Ala Leu Lys Ser Gly Tyr Glu Gly Arg Val Pro Leu Lys Ser Ala 
        515                 520                 525             


Arg Leu Phe Tyr Asp Ile Ser Glu Lys Ala Arg Arg Ile Val Glu Ser 
    530                 535                 540                 


Tyr Phe Met Leu Asn Ser Thr Leu Tyr Phe Ser Tyr Thr His Met Val 
545                 550                 555                 560 


Cys Arg Thr Ala Leu Ser Gly Gln Gln Asp Arg Arg Asn Asp Leu Ser 
                565                 570                 575     


His Pro Ile His Ala Asp Asn Cys Leu Leu Asp Pro Glu Ala Asn Glu 
            580                 585                 590         


Cys Trp Lys Glu Pro Pro Ala Tyr Thr Phe Arg Asp Tyr Ser Ala Leu 
        595                 600                 605             


Leu Tyr Met Asn Asp Asp Phe Glu Gly Gly Glu Phe Ile Phe Thr Glu 
    610                 615                 620                 


Met Asp Ala Lys Thr Val Thr Ala Ser Ile Lys Pro Lys Cys Gly Arg 
625                 630                 635                 640 


Met Ile Ser Phe Ser Ser Gly Gly Glu Asn Pro His Gly Val Lys Ala 
                645                 650                 655     


Val Thr Lys Gly Lys Arg Cys Ala Val Ala Leu Trp Phe Thr Leu Asp 
            660                 665                 670         


Pro Leu Tyr Arg Glu Leu Glu Arg Ile Gln Ala Asp Glu Val Ile Ala 
        675                 680                 685             


Ile Leu Asp Gln Glu Gln Gln Gly Lys His Glu Leu Asn Ile Asn Pro 
    690                 695                 700                 


Lys Asp Glu Leu 
705             


<210>  9911
<211>  736
<212>  PRT
<213>  Homo Sapiens

<400>  9911

Met Leu Arg Leu Leu Arg Pro Leu Leu Leu Leu Leu Leu Leu Pro Pro 
1               5                   10                  15      


Pro Gly Ser Pro Glu Pro Pro Gly Leu Thr Gln Leu Ser Pro Gly Ala 
            20                  25                  30          


Pro Pro Gln Ala Pro Asp Leu Leu Tyr Ala Asp Gly Leu Arg Ala Tyr 
        35                  40                  45              


Ala Ala Gly Ala Trp Ala Pro Ala Val Ala Leu Leu Arg Glu Ala Leu 
    50                  55                  60                  


Arg Ser Gln Ala Ala Leu Gly Arg Val Arg Leu Asp Cys Gly Ala Ser 
65                  70                  75                  80  


Cys Ala Ala Asp Pro Gly Ala Ala Leu Pro Ala Val Leu Leu Gly Ala 
                85                  90                  95      


Pro Glu Pro Asp Ser Gly Pro Gly Pro Thr Gln Gly Ser Trp Glu Arg 
            100                 105                 110         


Gln Leu Leu Arg Ala Ala Leu Arg Arg Ala Asp Cys Leu Thr Gln Cys 
        115                 120                 125             


Ala Ala Arg Arg Leu Gly Pro Gly Gly Ala Ala Arg Leu Arg Val Gly 
    130                 135                 140                 


Ser Ala Leu Arg Asp Ala Phe Arg Arg Arg Glu Pro Tyr Asn Tyr Leu 
145                 150                 155                 160 


Gln Arg Ala Tyr Tyr Gln Leu Lys Lys Leu Asp Leu Ala Ala Ala Ala 
                165                 170                 175     


Ala His Thr Phe Phe Val Ala Asn Pro Met His Leu Gln Met Arg Glu 
            180                 185                 190         


Asp Met Ala Lys Tyr Arg Arg Met Ser Gly Val Arg Pro Gln Ser Phe 
        195                 200                 205             


Arg Asp Leu Glu Thr Pro Pro His Trp Ala Ala Tyr Asp Thr Gly Leu 
    210                 215                 220                 


Glu Leu Leu Gly Arg Gln Glu Ala Gly Leu Ala Leu Pro Arg Leu Glu 
225                 230                 235                 240 


Glu Ala Leu Gln Gly Ser Leu Ala Gln Met Glu Ser Cys Arg Ala Asp 
                245                 250                 255     


Cys Glu Gly Pro Glu Glu Gln Gln Gly Ala Glu Glu Glu Glu Asp Gly 
            260                 265                 270         


Ala Ala Ser Gln Gly Gly Leu Tyr Glu Ala Ile Ala Gly His Trp Ile 
        275                 280                 285             


Gln Val Leu Gln Cys Arg Gln Arg Cys Val Gly Glu Thr Ala Thr Arg 
    290                 295                 300                 


Pro Gly Arg Ser Phe Pro Val Pro Asp Phe Leu Pro Asn Gln Leu Arg 
305                 310                 315                 320 


Arg Leu His Glu Ala His Ala Gln Val Gly Asn Leu Ser Gln Ala Ile 
                325                 330                 335     


Glu Asn Val Leu Ser Val Leu Leu Phe Tyr Pro Glu Asp Glu Ala Ala 
            340                 345                 350         


Lys Arg Ala Leu Asn Gln Tyr Gln Ala Gln Leu Gly Glu Pro Arg Pro 
        355                 360                 365             


Gly Leu Gly Pro Arg Glu Asp Ile Gln Arg Phe Ile Leu Arg Ser Leu 
    370                 375                 380                 


Gly Glu Lys Arg Gln Leu Tyr Tyr Ala Met Glu His Leu Gly Thr Ser 
385                 390                 395                 400 


Phe Lys Asp Pro Asp Pro Trp Thr Pro Ala Ala Leu Ile Pro Glu Ala 
                405                 410                 415     


Leu Arg Glu Lys Leu Arg Glu Asp Gln Glu Lys Arg Pro Trp Asp His 
            420                 425                 430         


Glu Pro Val Lys Pro Lys Pro Leu Thr Tyr Trp Lys Asp Val Leu Leu 
        435                 440                 445             


Leu Glu Gly Val Thr Leu Thr Gln Asp Ser Arg Gln Leu Asn Gly Ser 
    450                 455                 460                 


Glu Arg Ala Val Leu Asp Gly Leu Leu Thr Pro Ala Glu Cys Gly Val 
465                 470                 475                 480 


Leu Leu Gln Leu Ala Lys Asp Ala Ala Gly Ala Gly Ala Arg Ser Gly 
                485                 490                 495     


Tyr Arg Gly Arg Arg Ser Pro His Thr Pro His Glu Arg Phe Glu Gly 
            500                 505                 510         


Leu Thr Val Leu Lys Ala Ala Gln Leu Ala Arg Ala Gly Thr Val Gly 
        515                 520                 525             


Ser Gln Gly Ala Lys Leu Leu Leu Glu Val Ser Glu Arg Val Arg Thr 
    530                 535                 540                 


Leu Thr Gln Ala Tyr Phe Ser Pro Glu Arg Pro Leu His Leu Ser Phe 
545                 550                 555                 560 


Thr His Leu Val Cys Arg Ser Ala Ile Glu Gly Glu Gln Glu Gln Arg 
                565                 570                 575     


Met Asp Leu Ser His Pro Val His Ala Asp Asn Cys Val Leu Asp Pro 
            580                 585                 590         


Asp Thr Gly Glu Cys Trp Arg Glu Pro Pro Ala Tyr Thr Tyr Arg Asp 
        595                 600                 605             


Tyr Ser Gly Leu Leu Tyr Leu Asn Asp Asp Phe Gln Gly Gly Asp Leu 
    610                 615                 620                 


Phe Phe Thr Glu Pro Asn Ala Leu Thr Val Thr Ala Arg Val Arg Pro 
625                 630                 635                 640 


Arg Cys Gly Arg Leu Val Ala Phe Ser Ser Gly Val Glu Asn Pro His 
                645                 650                 655     


Gly Val Trp Ala Val Thr Arg Gly Arg Arg Cys Ala Leu Ala Leu Trp 
            660                 665                 670         


His Thr Trp Ala Pro Glu His Arg Glu Gln Glu Trp Ile Glu Ala Lys 
        675                 680                 685             


Glu Leu Leu Gln Glu Ser Gln Glu Glu Glu Glu Glu Glu Glu Glu Glu 
    690                 695                 700                 


Met Pro Ser Lys Asp Pro Ser Pro Glu Pro Pro Ser Arg Arg His Gln 
705                 710                 715                 720 


Arg Val Gln Asp Lys Thr Gly Arg Ala Pro Arg Val Arg Glu Glu Leu 
                725                 730                 735     


<210>  9912
<211>  85
<212>  PRT
<213>  Homo Sapiens

<400>  9912

Met Ala Arg Val Ala Trp Gly Leu Leu Trp Leu Leu Leu Gly Ser Ala 
1               5                   10                  15      


Gly Ala Gln Tyr Glu Lys Tyr Ser Phe Arg Gly Phe Pro Pro Glu Asp 
            20                  25                  30          


Leu Met Pro Leu Ala Ala Ala Tyr Gly His Ala Leu Glu Gln Tyr Glu 
        35                  40                  45              


Gly Glu Ser Trp Arg Glu Ser Ala Arg Tyr Leu Glu Ala Ala Leu Arg 
    50                  55                  60                  


Leu His Arg Leu Leu Arg Asp Ser Glu Ala Phe Cys His Ala Asn Cys 
65                  70                  75                  80  


Ser Gly Pro Ala Pro 
                85  


<210>  9913
<211>  437
<212>  PRT
<213>  Homo Sapiens

<400>  9913

Met Ala Arg Val Ala Trp Gly Leu Leu Trp Leu Leu Leu Gly Ser Ala 
1               5                   10                  15      


Gly Ala Gln Tyr Glu Lys Tyr Ser Phe Arg Gly Phe Pro Pro Glu Asp 
            20                  25                  30          


Leu Met Pro Leu Ala Ala Ala Tyr Gly His Ala Leu Glu Gln Tyr Glu 
        35                  40                  45              


Gly Glu Ser Trp Arg Glu Ser Ala Arg Tyr Leu Glu Ala Ala Leu Arg 
    50                  55                  60                  


Leu His Arg Leu Leu Arg Asp Ser Glu Ala Phe Cys His Ala Asn Cys 
65                  70                  75                  80  


Ser Gly Pro Ala Pro Ala Ala Lys Pro Asp Pro Asp Gly Gly Arg Ala 
                85                  90                  95      


Asp Glu Trp Ala Cys Glu Leu Arg Leu Phe Gly Arg Val Leu Glu Arg 
            100                 105                 110         


Ala Ala Cys Leu Arg Arg Cys Lys Arg Thr Leu Pro Ala Phe Gln Val 
        115                 120                 125             


Pro Tyr Pro Pro Arg Gln Leu Leu Arg Asp Phe Gln Ser Arg Leu Pro 
    130                 135                 140                 


Tyr Gln Tyr Leu His Tyr Ala Leu Phe Lys Ala Asn Arg Leu Glu Lys 
145                 150                 155                 160 


Ala Val Ala Ala Ala Tyr Thr Phe Leu Gln Arg Asn Pro Lys His Glu 
                165                 170                 175     


Leu Thr Ala Lys Tyr Leu Asn Tyr Tyr Gln Gly Met Leu Asp Val Ala 
            180                 185                 190         


Asp Glu Ser Leu Thr Asp Leu Glu Ala Gln Pro Tyr Glu Ala Val Phe 
        195                 200                 205             


Leu Arg Ala Val Lys Leu Tyr Asn Ser Gly Asp Phe Arg Ser Ser Thr 
    210                 215                 220                 


Glu Asp Met Glu Arg Ala Leu Ser Glu Tyr Leu Ala Val Phe Ala Arg 
225                 230                 235                 240 


Cys Leu Ala Gly Cys Glu Gly Ala His Glu Gln Val Asp Phe Lys Asp 
                245                 250                 255     


Phe Tyr Pro Ala Ile Ala Asp Leu Phe Ala Glu Ser Leu Gln Cys Lys 
            260                 265                 270         


Val Asp Cys Glu Ala Asn Leu Thr Pro Asn Val Gly Gly Tyr Phe Val 
        275                 280                 285             


Asp Lys Phe Val Ala Thr Met Tyr His Tyr Leu Gln Phe Ala Tyr Tyr 
    290                 295                 300                 


Lys Leu Asn Asp Val Arg Gln Ala Ala Arg Ser Ala Ala Ser Tyr Met 
305                 310                 315                 320 


Leu Phe Asp Pro Lys Asp Ser Val Met Gln Gln Asn Leu Val Tyr Tyr 
                325                 330                 335     


Arg Phe His Arg Ala Arg Trp Gly Leu Glu Glu Glu Asp Phe Gln Pro 
            340                 345                 350         


Arg Glu Glu Ala Met Leu Tyr His Asn Gln Thr Ala Glu Leu Arg Glu 
        355                 360                 365             


Leu Leu Glu Phe Thr His Met Tyr Leu Gln Ser Asp Asp Glu Met Glu 
    370                 375                 380                 


Leu Glu Glu Thr Glu Pro Pro Leu Glu Pro Glu Asp Ala Leu Ser Asp 
385                 390                 395                 400 


Ala Glu Phe Glu Gly Glu Gly Asp Tyr Glu Glu Gly Met Tyr Ala Asp 
                405                 410                 415     


Trp Trp Gln Glu Pro Asp Ala Lys Gly Asp Glu Ala Glu Ala Glu Pro 
            420                 425                 430         


Glu Pro Glu Leu Ala 
        435         


<210>  9914
<211>  437
<212>  PRT
<213>  Homo Sapiens

<400>  9914

Met Ala Arg Val Ala Trp Gly Leu Leu Trp Leu Leu Leu Gly Ser Ala 
1               5                   10                  15      


Gly Ala Gln Tyr Glu Lys Tyr Ser Phe Arg Gly Phe Pro Pro Glu Asp 
            20                  25                  30          


Leu Met Pro Leu Ala Ala Ala Tyr Gly His Ala Leu Glu Gln Tyr Glu 
        35                  40                  45              


Gly Glu Ser Trp Arg Glu Ser Ala Arg Tyr Leu Glu Ala Ala Leu Arg 
    50                  55                  60                  


Leu His Arg Leu Leu Arg Asp Ser Glu Ala Phe Cys His Ala Asn Cys 
65                  70                  75                  80  


Ser Gly Pro Ala Pro Ala Ala Lys Pro Asp Pro Asp Gly Gly Arg Ala 
                85                  90                  95      


Asp Glu Trp Ala Cys Glu Leu Arg Leu Phe Gly Arg Val Leu Glu Arg 
            100                 105                 110         


Ala Ala Cys Leu Arg Arg Cys Lys Arg Thr Leu Pro Ala Phe Gln Val 
        115                 120                 125             


Pro Tyr Pro Pro Arg Gln Leu Leu Arg Asp Phe Gln Ser Arg Leu Pro 
    130                 135                 140                 


Tyr Gln Tyr Leu His Tyr Ala Leu Phe Lys Ala Asn Arg Leu Glu Lys 
145                 150                 155                 160 


Ala Val Ala Ala Ala Tyr Thr Phe Leu Gln Arg Asn Pro Lys His Glu 
                165                 170                 175     


Leu Thr Ala Lys Tyr Leu Asn Tyr Tyr Gln Gly Met Leu Asp Val Ala 
            180                 185                 190         


Asp Glu Ser Leu Thr Asp Leu Glu Ala Gln Pro Tyr Glu Ala Val Phe 
        195                 200                 205             


Leu Arg Ala Val Lys Leu Tyr Asn Ser Gly Asp Phe Arg Ser Ser Thr 
    210                 215                 220                 


Glu Asp Met Glu Arg Ala Leu Ser Glu Tyr Leu Ala Val Phe Ala Arg 
225                 230                 235                 240 


Cys Leu Ala Gly Cys Glu Gly Ala His Glu Gln Val Asp Phe Lys Asp 
                245                 250                 255     


Phe Tyr Pro Ala Ile Ala Asp Leu Phe Ala Glu Ser Leu Gln Cys Lys 
            260                 265                 270         


Val Asp Cys Glu Ala Asn Leu Thr Pro Asn Val Gly Gly Tyr Phe Val 
        275                 280                 285             


Asp Lys Phe Val Ala Thr Met Tyr His Tyr Leu Gln Phe Ala Tyr Tyr 
    290                 295                 300                 


Lys Leu Asn Asp Val Arg Gln Ala Ala Arg Ser Ala Ala Ser Tyr Met 
305                 310                 315                 320 


Leu Phe Asp Pro Lys Asp Ser Val Met Gln Gln Asn Leu Val Tyr Tyr 
                325                 330                 335     


Arg Phe His Arg Ala Arg Trp Gly Leu Glu Glu Glu Asp Phe Gln Pro 
            340                 345                 350         


Arg Glu Glu Ala Met Leu Tyr His Asn Gln Thr Ala Glu Leu Arg Glu 
        355                 360                 365             


Leu Leu Glu Phe Thr His Met Tyr Leu Gln Ser Asp Asp Glu Met Glu 
    370                 375                 380                 


Leu Glu Glu Thr Glu Pro Pro Leu Glu Pro Glu Asp Ala Leu Ser Asp 
385                 390                 395                 400 


Ala Glu Phe Glu Gly Glu Gly Asp Tyr Glu Glu Gly Met Tyr Ala Asp 
                405                 410                 415     


Trp Trp Gln Glu Pro Asp Ala Lys Gly Asp Glu Ala Glu Ala Glu Pro 
            420                 425                 430         


Glu Pro Glu Leu Ala 
        435         


<210>  9915
<211>  221
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9915

Xaa Lys Arg Thr Leu Pro Ala Phe Gln Val Pro Tyr Pro Pro Arg Gln 
1               5                   10                  15      


Leu Leu Arg Asp Phe Gln Ser Arg Leu Pro Tyr Gln Tyr Leu His Tyr 
            20                  25                  30          


Ala Leu Phe Lys Ala Asn Arg Leu Glu Lys Ala Val Ala Ala Ala Tyr 
        35                  40                  45              


Thr Phe Leu Gln Arg Asn Pro Lys His Glu Leu Thr Ala Lys Tyr Leu 
    50                  55                  60                  


Asn Tyr Tyr Gln Gly Met Leu Asp Val Ala Asp Glu Ser Leu Thr Asp 
65                  70                  75                  80  


Leu Glu Ala Gln Pro Tyr Glu Ala Val Phe Leu Arg Ala Val Lys Leu 
                85                  90                  95      


Tyr Asn Ser Gly Asp Phe Arg Ser Ser Thr Glu Asp Met Glu Arg Ala 
            100                 105                 110         


Leu Ser Glu Tyr Leu Ala Val Phe Ala Arg Cys Leu Ala Gly Cys Glu 
        115                 120                 125             


Gly Ala His Glu Gln Val Asp Phe Lys Asp Phe Tyr Pro Ala Ile Ala 
    130                 135                 140                 


Val Asn Asp Val Arg Gln Ala Ala Arg Ser Ala Ala Ser Tyr Met Leu 
145                 150                 155                 160 


Phe Asp Pro Lys Asp Ser Val Met Gln Gln Asn Leu Val Tyr Tyr Arg 
                165                 170                 175     


Phe His Arg Ala Arg Trp Gly Leu Glu Glu Glu Asp Phe Gln Pro Arg 
            180                 185                 190         


Glu Glu Ala Met Leu Tyr His Asn Gln Thr Ala Glu Leu Arg Glu Leu 
        195                 200                 205             


Leu Glu Phe Thr His Met Tyr Leu Gln Ser Asp Asp Glu 
    210                 215                 220     


<210>  9916
<211>  73
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9916

Xaa Leu Arg Glu Leu Leu Glu Phe Thr His Met Tyr Leu Gln Ser Asp 
1               5                   10                  15      


Asp Glu Met Glu Leu Glu Glu Thr Glu Pro Pro Leu Glu Pro Glu Asp 
            20                  25                  30          


Ala Leu Ser Asp Ala Glu Phe Glu Gly Glu Gly Asp Tyr Glu Glu Gly 
        35                  40                  45              


Met Tyr Ala Asp Trp Trp Gln Glu Pro Asp Ala Lys Gly Asp Glu Ala 
    50                  55                  60                  


Glu Ala Glu Pro Glu Pro Glu Leu Ala 
65                  70              


<210>  9917
<211>  534
<212>  PRT
<213>  Homo Sapiens

<400>  9917

Met Ile Trp Tyr Ile Leu Ile Ile Gly Ile Leu Leu Pro Gln Ser Leu 
1               5                   10                  15      


Ala His Pro Gly Phe Phe Thr Ser Ile Gly Gln Met Thr Asp Leu Ile 
            20                  25                  30          


His Thr Glu Lys Asp Leu Val Thr Ser Leu Lys Asp Tyr Ile Lys Ala 
        35                  40                  45              


Glu Glu Asp Lys Leu Glu Gln Ile Lys Lys Trp Ala Glu Lys Leu Asp 
    50                  55                  60                  


Arg Leu Thr Ser Thr Ala Thr Lys Asp Pro Glu Gly Phe Val Gly His 
65                  70                  75                  80  


Pro Val Asn Ala Phe Lys Leu Met Lys Arg Leu Asn Thr Glu Trp Ser 
                85                  90                  95      


Glu Leu Glu Asn Leu Val Leu Lys Asp Met Ser Asp Gly Phe Ile Ser 
            100                 105                 110         


Asn Leu Thr Ile Gln Arg Gln Tyr Phe Pro Asn Asp Glu Asp Gln Val 
        115                 120                 125             


Gly Ala Ala Lys Ala Leu Leu Arg Leu Gln Asp Thr Tyr Asn Leu Asp 
    130                 135                 140                 


Thr Asp Thr Ile Ser Lys Gly Asn Leu Pro Gly Val Lys His Lys Ser 
145                 150                 155                 160 


Phe Leu Thr Ala Glu Asp Cys Phe Glu Leu Gly Lys Val Ala Tyr Thr 
                165                 170                 175     


Glu Ala Asp Tyr Tyr His Thr Glu Leu Trp Met Glu Gln Ala Leu Arg 
            180                 185                 190         


Gln Leu Asp Glu Gly Glu Ile Ser Thr Ile Asp Lys Val Ser Val Leu 
        195                 200                 205             


Asp Tyr Leu Ser Tyr Ala Val Tyr Gln Gln Gly Asp Leu Asp Lys Ala 
    210                 215                 220                 


Leu Leu Leu Thr Lys Lys Leu Leu Glu Leu Asp Pro Glu His Gln Arg 
225                 230                 235                 240 


Ala Asn Gly Asn Leu Lys Tyr Phe Glu Tyr Ile Met Ala Lys Glu Lys 
                245                 250                 255     


Asp Val Asn Lys Ser Ala Ser Asp Asp Gln Ser Asp Gln Lys Thr Thr 
            260                 265                 270         


Pro Lys Lys Lys Gly Val Ala Val Asp Tyr Leu Pro Glu Arg Gln Lys 
        275                 280                 285             


Tyr Glu Met Leu Cys Arg Gly Glu Gly Ile Lys Met Thr Pro Arg Arg 
    290                 295                 300                 


Gln Lys Lys Leu Phe Cys Arg Tyr His Asp Gly Asn Arg Asn Pro Lys 
305                 310                 315                 320 


Phe Ile Leu Ala Pro Ala Lys Gln Glu Asp Glu Trp Asp Lys Pro Arg 
                325                 330                 335     


Ile Ile Arg Phe His Asp Ile Ile Ser Asp Ala Glu Ile Glu Ile Val 
            340                 345                 350         


Lys Asp Leu Ala Lys Pro Arg Leu Ser Arg Ala Thr Val His Asp Pro 
        355                 360                 365             


Glu Thr Gly Lys Leu Thr Thr Ala Gln Tyr Arg Val Ser Lys Ser Ala 
    370                 375                 380                 


Trp Leu Ser Gly Tyr Glu Asn Pro Val Val Ser Arg Ile Asn Met Arg 
385                 390                 395                 400 


Ile Gln Asp Leu Thr Gly Leu Asp Val Ser Thr Ala Glu Glu Leu Gln 
                405                 410                 415     


Val Ala Asn Tyr Gly Val Gly Gly Gln Tyr Glu Pro His Phe Asp Phe 
            420                 425                 430         


Ala Arg Lys Asp Glu Pro Asp Ala Phe Lys Glu Leu Gly Thr Gly Asn 
        435                 440                 445             


Arg Ile Ala Thr Trp Leu Phe Tyr Met Ser Asp Val Ser Ala Gly Gly 
    450                 455                 460                 


Ala Thr Val Phe Pro Glu Val Gly Ala Ser Val Trp Pro Lys Lys Gly 
465                 470                 475                 480 


Thr Ala Val Phe Trp Tyr Asn Leu Phe Ala Ser Gly Glu Gly Asp Tyr 
                485                 490                 495     


Ser Thr Arg His Ala Ala Cys Pro Val Leu Val Gly Asn Lys Trp Val 
            500                 505                 510         


Ser Asn Lys Trp Leu His Glu Arg Gly Gln Glu Phe Arg Arg Pro Cys 
        515                 520                 525             


Thr Leu Ser Glu Leu Glu 
    530                 


<210>  9918
<211>  534
<212>  PRT
<213>  Homo Sapiens

<400>  9918

Met Ile Trp Tyr Ile Leu Ile Ile Gly Ile Leu Leu Pro Gln Ser Leu 
1               5                   10                  15      


Ala His Pro Gly Phe Phe Thr Ser Ile Gly Gln Met Thr Asp Leu Ile 
            20                  25                  30          


His Thr Glu Lys Asp Leu Val Thr Ser Leu Lys Asp Tyr Ile Lys Ala 
        35                  40                  45              


Glu Glu Asp Lys Leu Glu Gln Ile Lys Lys Trp Ala Glu Lys Leu Asp 
    50                  55                  60                  


Arg Leu Thr Ser Thr Ala Thr Lys Asp Pro Glu Gly Phe Val Gly His 
65                  70                  75                  80  


Pro Val Asn Ala Phe Lys Leu Met Lys Arg Leu Asn Thr Glu Trp Ser 
                85                  90                  95      


Glu Leu Glu Asn Leu Val Leu Lys Asp Met Ser Asp Gly Phe Ile Ser 
            100                 105                 110         


Asn Leu Thr Ile Gln Arg Gln Tyr Phe Pro Asn Asp Glu Asp Gln Val 
        115                 120                 125             


Gly Ala Ala Lys Ala Leu Leu Arg Leu Gln Asp Thr Tyr Asn Leu Asp 
    130                 135                 140                 


Thr Asp Thr Ile Ser Lys Gly Asn Leu Pro Gly Val Lys His Lys Ser 
145                 150                 155                 160 


Phe Leu Thr Ala Glu Asp Cys Phe Glu Leu Gly Lys Val Ala Tyr Thr 
                165                 170                 175     


Glu Ala Asp Tyr Tyr His Thr Glu Leu Trp Met Glu Gln Ala Leu Arg 
            180                 185                 190         


Gln Leu Asp Glu Gly Glu Ile Ser Thr Ile Asp Lys Val Ser Val Leu 
        195                 200                 205             


Asp Tyr Leu Ser Tyr Ala Val Tyr Gln Gln Gly Asp Leu Asp Lys Ala 
    210                 215                 220                 


Leu Leu Leu Thr Lys Lys Leu Leu Glu Leu Asp Pro Glu His Gln Arg 
225                 230                 235                 240 


Ala Asn Gly Asn Leu Lys Tyr Phe Glu Tyr Ile Met Ala Lys Glu Lys 
                245                 250                 255     


Asp Val Asn Lys Ser Ala Ser Asp Asp Gln Ser Asp Gln Lys Thr Thr 
            260                 265                 270         


Pro Lys Lys Lys Gly Val Ala Val Asp Tyr Leu Pro Glu Arg Gln Lys 
        275                 280                 285             


Tyr Glu Met Leu Cys Arg Gly Glu Gly Ile Lys Met Thr Pro Arg Arg 
    290                 295                 300                 


Gln Lys Lys Leu Phe Cys Arg Tyr His Asp Gly Asn Arg Asn Pro Lys 
305                 310                 315                 320 


Phe Ile Leu Ala Pro Ala Lys Gln Glu Asp Glu Trp Asp Lys Pro Arg 
                325                 330                 335     


Ile Ile Arg Phe His Asp Ile Ile Ser Asp Ala Glu Ile Glu Ile Val 
            340                 345                 350         


Lys Asp Leu Ala Lys Pro Arg Leu Arg Arg Ala Thr Ile Ser Asn Pro 
        355                 360                 365             


Ile Thr Gly Asp Leu Glu Thr Val His Tyr Arg Ile Ser Lys Ser Ala 
    370                 375                 380                 


Trp Leu Ser Gly Tyr Glu Asn Pro Val Val Ser Arg Ile Asn Met Arg 
385                 390                 395                 400 


Ile Gln Asp Leu Thr Gly Leu Asp Val Ser Thr Ala Glu Glu Leu Gln 
                405                 410                 415     


Val Ala Asn Tyr Gly Val Gly Gly Gln Tyr Glu Pro His Phe Asp Phe 
            420                 425                 430         


Ala Arg Lys Asp Glu Pro Asp Ala Phe Lys Glu Leu Gly Thr Gly Asn 
        435                 440                 445             


Arg Ile Ala Thr Trp Leu Phe Tyr Met Ser Asp Val Ser Ala Gly Gly 
    450                 455                 460                 


Ala Thr Val Phe Pro Glu Val Gly Ala Ser Val Trp Pro Lys Lys Gly 
465                 470                 475                 480 


Thr Ala Val Phe Trp Tyr Asn Leu Phe Ala Ser Gly Glu Gly Asp Tyr 
                485                 490                 495     


Ser Thr Arg His Ala Ala Cys Pro Val Leu Val Gly Asn Lys Trp Val 
            500                 505                 510         


Ser Asn Lys Trp Leu His Glu Arg Gly Gln Glu Phe Arg Arg Pro Cys 
        515                 520                 525             


Thr Leu Ser Glu Leu Glu 
    530                 


<210>  9919
<211>  534
<212>  PRT
<213>  Homo Sapiens

<400>  9919

Met Ile Trp Tyr Ile Leu Ile Ile Gly Ile Leu Leu Pro Gln Ser Leu 
1               5                   10                  15      


Ala His Pro Gly Phe Phe Thr Ser Ile Gly Gln Met Thr Asp Leu Ile 
            20                  25                  30          


His Thr Glu Lys Asp Leu Val Thr Ser Leu Lys Asp Tyr Ile Lys Ala 
        35                  40                  45              


Glu Glu Asp Lys Leu Glu Gln Ile Lys Lys Trp Ala Glu Lys Leu Asp 
    50                  55                  60                  


Arg Leu Thr Ser Thr Ala Thr Lys Asp Pro Glu Gly Phe Val Gly His 
65                  70                  75                  80  


Pro Val Asn Ala Phe Lys Leu Met Lys Arg Leu Asn Thr Glu Trp Ser 
                85                  90                  95      


Glu Leu Glu Asn Leu Val Leu Lys Asp Met Ser Asp Gly Phe Ile Ser 
            100                 105                 110         


Asn Leu Thr Ile Gln Arg Gln Tyr Phe Pro Asn Asp Glu Asp Gln Val 
        115                 120                 125             


Gly Ala Ala Lys Ala Leu Leu Arg Leu Gln Asp Thr Tyr Asn Leu Asp 
    130                 135                 140                 


Thr Asp Thr Ile Ser Lys Gly Asn Leu Pro Gly Val Lys His Lys Ser 
145                 150                 155                 160 


Phe Leu Thr Ala Glu Asp Cys Phe Glu Leu Gly Lys Val Ala Tyr Thr 
                165                 170                 175     


Glu Ala Asp Tyr Tyr His Thr Glu Leu Trp Met Glu Gln Ala Leu Arg 
            180                 185                 190         


Gln Leu Asp Glu Gly Glu Ile Ser Thr Ile Asp Lys Val Ser Val Leu 
        195                 200                 205             


Asp Tyr Leu Ser Tyr Ala Val Tyr Gln Gln Gly Asp Leu Asp Lys Ala 
    210                 215                 220                 


Leu Leu Leu Thr Lys Lys Leu Leu Glu Leu Asp Pro Glu His Gln Arg 
225                 230                 235                 240 


Ala Asn Gly Asn Leu Lys Tyr Phe Glu Tyr Ile Met Ala Lys Glu Lys 
                245                 250                 255     


Asp Val Asn Lys Ser Ala Ser Asp Asp Gln Ser Asp Gln Lys Thr Thr 
            260                 265                 270         


Pro Lys Lys Lys Gly Val Ala Val Asp Tyr Leu Pro Glu Arg Gln Lys 
        275                 280                 285             


Tyr Glu Met Leu Cys Arg Gly Glu Gly Ile Lys Met Thr Pro Arg Arg 
    290                 295                 300                 


Gln Lys Lys Leu Phe Cys Arg Tyr His Asp Gly Asn Arg Asn Pro Lys 
305                 310                 315                 320 


Phe Ile Leu Ala Pro Ala Lys Gln Glu Asp Glu Trp Asp Lys Pro Arg 
                325                 330                 335     


Ile Ile Arg Phe His Asp Ile Ile Ser Asp Ala Glu Ile Glu Ile Val 
            340                 345                 350         


Lys Asp Leu Ala Lys Pro Arg Leu Ser Arg Ala Thr Val His Asp Pro 
        355                 360                 365             


Glu Thr Gly Lys Leu Thr Thr Ala Gln Tyr Arg Val Ser Lys Ser Ala 
    370                 375                 380                 


Trp Leu Ser Gly Tyr Glu Asn Pro Val Val Ser Arg Ile Asn Met Arg 
385                 390                 395                 400 


Ile Gln Asp Leu Thr Gly Leu Asp Val Ser Thr Ala Glu Glu Leu Gln 
                405                 410                 415     


Val Ala Asn Tyr Gly Val Gly Gly Gln Tyr Glu Pro His Phe Asp Phe 
            420                 425                 430         


Ala Arg Lys Asp Glu Pro Asp Ala Phe Lys Glu Leu Gly Thr Gly Asn 
        435                 440                 445             


Arg Ile Ala Thr Trp Leu Phe Tyr Met Ser Asp Val Ser Ala Gly Gly 
    450                 455                 460                 


Ala Thr Val Phe Pro Glu Val Gly Ala Ser Val Trp Pro Lys Lys Gly 
465                 470                 475                 480 


Thr Ala Val Phe Trp Tyr Asn Leu Phe Ala Ser Gly Glu Gly Asp Tyr 
                485                 490                 495     


Ser Thr Arg His Ala Ala Cys Pro Val Leu Val Gly Asn Lys Trp Val 
            500                 505                 510         


Ser Asn Lys Trp Leu His Glu Arg Gly Gln Glu Phe Arg Arg Pro Cys 
        515                 520                 525             


Thr Leu Ser Glu Leu Glu 
    530                 


<210>  9920
<211>  516
<212>  PRT
<213>  Homo Sapiens

<400>  9920

Met Ile Trp Tyr Ile Leu Ile Ile Gly Ile Leu Leu Pro Gln Ser Leu 
1               5                   10                  15      


Ala His Pro Gly Phe Phe Thr Ser Ile Gly Gln Met Thr Asp Leu Ile 
            20                  25                  30          


His Thr Glu Lys Asp Leu Val Thr Ser Leu Lys Asp Tyr Ile Lys Ala 
        35                  40                  45              


Glu Glu Asp Lys Leu Glu Gln Ile Lys Lys Trp Ala Glu Lys Leu Asp 
    50                  55                  60                  


Arg Leu Thr Ser Thr Ala Thr Lys Asp Pro Glu Gly Phe Val Gly His 
65                  70                  75                  80  


Pro Val Asn Ala Phe Lys Leu Met Lys Arg Leu Asn Thr Glu Trp Ser 
                85                  90                  95      


Glu Leu Glu Asn Leu Val Leu Lys Asp Met Ser Asp Gly Phe Ile Ser 
            100                 105                 110         


Asn Leu Thr Ile Gln Arg Gln Tyr Phe Pro Asn Asp Glu Asp Gln Val 
        115                 120                 125             


Gly Ala Ala Lys Ala Leu Leu Arg Leu Gln Asp Thr Tyr Asn Leu Asp 
    130                 135                 140                 


Thr Asp Thr Ile Ser Lys Gly Asn Leu Pro Gly Val Lys His Lys Ser 
145                 150                 155                 160 


Phe Leu Thr Ala Glu Asp Cys Phe Glu Leu Gly Lys Val Ala Tyr Thr 
                165                 170                 175     


Glu Ala Asp Tyr Tyr His Thr Glu Leu Trp Met Glu Gln Ala Leu Arg 
            180                 185                 190         


Gln Leu Asp Glu Gly Glu Ile Ser Thr Ile Asp Lys Val Ser Val Leu 
        195                 200                 205             


Asp Tyr Leu Ser Tyr Ala Val Tyr Gln Gln Gly Asp Leu Asp Lys Ala 
    210                 215                 220                 


Leu Leu Leu Thr Lys Lys Leu Leu Glu Leu Asp Pro Glu His Gln Arg 
225                 230                 235                 240 


Ala Asn Gly Asn Leu Lys Tyr Phe Glu Tyr Ile Met Ala Lys Glu Lys 
                245                 250                 255     


Asp Val Asn Lys Ser Ala Ser Asp Asp Gln Ser Asp Gln Lys Thr Thr 
            260                 265                 270         


Pro Lys Lys Lys Gly Val Ala Val Asp Tyr Leu Pro Glu Arg Gln Lys 
        275                 280                 285             


Tyr Glu Met Leu Cys Arg Gly Glu Gly Ile Lys Met Thr Pro Arg Arg 
    290                 295                 300                 


Gln Lys Lys Leu Phe Cys Arg Tyr His Asp Gly Asn Arg Asn Pro Lys 
305                 310                 315                 320 


Phe Ile Leu Ala Pro Ala Lys Gln Glu Asp Glu Trp Asp Lys Pro Arg 
                325                 330                 335     


Ile Ile Arg Phe His Asp Ile Ile Ser Asp Ala Glu Ile Glu Ile Val 
            340                 345                 350         


Lys Asp Leu Ala Lys Pro Arg Leu Ser Arg Ala Thr Val His Asp Pro 
        355                 360                 365             


Glu Thr Gly Lys Leu Thr Thr Ala Gln Tyr Arg Val Ser Lys Ser Ala 
    370                 375                 380                 


Trp Leu Ser Gly Tyr Glu Asn Pro Val Val Ser Arg Ile Asn Met Arg 
385                 390                 395                 400 


Ile Gln Asp Leu Thr Gly Leu Asp Val Ser Thr Ala Glu Glu Leu Gln 
                405                 410                 415     


Lys Asp Glu Pro Asp Ala Phe Lys Glu Leu Gly Thr Gly Asn Arg Ile 
            420                 425                 430         


Ala Thr Trp Leu Phe Tyr Met Ser Asp Val Ser Ala Gly Gly Ala Thr 
        435                 440                 445             


Val Phe Pro Glu Val Gly Ala Ser Val Trp Pro Lys Lys Gly Thr Ala 
    450                 455                 460                 


Val Phe Trp Tyr Asn Leu Phe Ala Ser Gly Glu Gly Asp Tyr Ser Thr 
465                 470                 475                 480 


Arg His Ala Ala Cys Pro Val Leu Val Gly Asn Lys Trp Val Ser Asn 
                485                 490                 495     


Lys Trp Leu His Glu Arg Gly Gln Glu Phe Arg Arg Pro Cys Thr Leu 
            500                 505                 510         


Ser Glu Leu Glu 
        515     


<210>  9921
<211>  534
<212>  PRT
<213>  Homo Sapiens

<400>  9921

Met Ile Trp Tyr Ile Leu Ile Ile Gly Ile Leu Leu Pro Gln Ser Leu 
1               5                   10                  15      


Ala His Pro Gly Phe Phe Thr Ser Ile Gly Gln Met Thr Asp Leu Ile 
            20                  25                  30          


His Thr Glu Lys Asp Leu Val Thr Ser Leu Lys Asp Tyr Ile Lys Ala 
        35                  40                  45              


Glu Glu Asp Lys Leu Glu Gln Ile Lys Lys Trp Ala Glu Lys Leu Asp 
    50                  55                  60                  


Arg Leu Thr Ser Thr Ala Thr Lys Asp Pro Glu Gly Phe Val Gly His 
65                  70                  75                  80  


Pro Val Asn Ala Phe Lys Leu Met Lys Arg Leu Asn Thr Glu Trp Ser 
                85                  90                  95      


Glu Leu Glu Asn Leu Val Leu Lys Asp Met Ser Asp Gly Phe Ile Ser 
            100                 105                 110         


Asn Leu Thr Ile Gln Arg Gln Tyr Phe Pro Asn Asp Glu Asp Gln Val 
        115                 120                 125             


Gly Ala Ala Lys Ala Leu Leu Arg Leu Gln Asp Thr Tyr Asn Leu Asp 
    130                 135                 140                 


Thr Asp Thr Ile Ser Lys Gly Asn Leu Pro Gly Val Lys His Lys Ser 
145                 150                 155                 160 


Phe Leu Thr Ala Glu Asp Cys Phe Glu Leu Gly Lys Val Ala Tyr Thr 
                165                 170                 175     


Glu Ala Asp Tyr Tyr His Thr Glu Leu Trp Met Glu Gln Ala Leu Arg 
            180                 185                 190         


Gln Leu Asp Glu Gly Glu Ile Ser Thr Ile Asp Lys Val Ser Val Leu 
        195                 200                 205             


Asp Tyr Leu Ser Tyr Ala Val Tyr Gln Gln Gly Asp Leu Asp Lys Ala 
    210                 215                 220                 


Leu Leu Leu Thr Lys Lys Leu Leu Glu Leu Asp Pro Glu His Gln Arg 
225                 230                 235                 240 


Ala Asn Gly Asn Leu Lys Tyr Phe Glu Tyr Ile Met Ala Lys Glu Lys 
                245                 250                 255     


Asp Val Asn Lys Ser Ala Ser Asp Asp Gln Ser Asp Gln Lys Thr Thr 
            260                 265                 270         


Pro Lys Lys Lys Gly Val Ala Val Asp Tyr Leu Pro Glu Arg Gln Lys 
        275                 280                 285             


Tyr Glu Met Leu Cys Arg Gly Glu Gly Ile Lys Met Thr Pro Arg Arg 
    290                 295                 300                 


Gln Lys Lys Leu Phe Cys Arg Tyr His Asp Gly Asn Arg Asn Pro Lys 
305                 310                 315                 320 


Phe Ile Leu Ala Pro Ala Lys Gln Glu Asp Glu Trp Asp Lys Pro Arg 
                325                 330                 335     


Ile Ile Arg Phe His Asp Ile Ile Ser Asp Ala Glu Ile Glu Ile Val 
            340                 345                 350         


Lys Asp Leu Ala Lys Pro Arg Leu Arg Arg Ala Thr Ile Ser Asn Pro 
        355                 360                 365             


Ile Thr Gly Asp Leu Glu Thr Val His Tyr Arg Ile Ser Lys Ser Ala 
    370                 375                 380                 


Trp Leu Ser Gly Tyr Glu Asn Pro Val Val Ser Arg Ile Asn Met Arg 
385                 390                 395                 400 


Ile Gln Asp Leu Thr Gly Leu Asp Val Ser Thr Ala Glu Glu Leu Gln 
                405                 410                 415     


Val Ala Asn Tyr Gly Val Gly Gly Gln Tyr Glu Pro His Phe Asp Phe 
            420                 425                 430         


Ala Arg Lys Asp Glu Pro Asp Ala Phe Lys Glu Leu Gly Thr Gly Asn 
        435                 440                 445             


Arg Ile Ala Thr Trp Leu Phe Tyr Met Ser Asp Val Ser Ala Gly Gly 
    450                 455                 460                 


Ala Thr Val Phe Pro Glu Val Gly Ala Ser Val Trp Pro Lys Lys Gly 
465                 470                 475                 480 


Thr Ala Val Phe Trp Tyr Asn Leu Phe Ala Ser Gly Glu Gly Asp Tyr 
                485                 490                 495     


Ser Thr Arg His Ala Ala Cys Pro Val Leu Val Gly Asn Lys Trp Val 
            500                 505                 510         


Ser Asn Lys Trp Leu His Glu Arg Gly Gln Glu Phe Arg Arg Pro Cys 
        515                 520                 525             


Thr Leu Ser Glu Leu Glu 
    530                 


<210>  9922
<211>  50
<212>  PRT
<213>  Homo Sapiens

<400>  9922

Met Lys Leu Trp Val Ser Ala Leu Leu Met Ala Trp Phe Gly Val Leu 
1               5                   10                  15      


Ser Cys Val Gln Ala Glu Phe Phe Thr Ser Ile Gly His Met Thr Asp 
            20                  25                  30          


Leu Ile Tyr Ala Glu Lys Glu Leu Val Gln Ser Leu Lys Glu Tyr Ile 
        35                  40                  45              


Leu Val 
    50  


<210>  9923
<211>  101
<212>  PRT
<213>  Homo Sapiens

<400>  9923

Met Lys Leu Trp Val Ser Ala Leu Leu Met Ala Trp Phe Gly Val Leu 
1               5                   10                  15      


Ser Cys Val Gln Ala Glu Phe Phe Thr Ser Ile Gly His Met Thr Asp 
            20                  25                  30          


Leu Ile Tyr Ala Glu Lys Glu Leu Val Gln Ser Leu Lys Glu Tyr Ile 
        35                  40                  45              


Leu Val Glu Glu Ala Lys Leu Ser Lys Ile Lys Ser Trp Ala Asn Lys 
    50                  55                  60                  


Met Glu Ala Leu Thr Ser Lys Ser Ala Ala Asp Ala Glu Gly Tyr Leu 
65                  70                  75                  80  


Ala His Pro Val Asn Ala Tyr Lys Leu Val Lys Arg Leu Asn Thr Asp 
                85                  90                  95      


Trp Pro Ala Leu Glu 
            100     


<210>  9924
<211>  114
<212>  PRT
<213>  Homo Sapiens

<400>  9924

Met Lys Leu Trp Val Ser Ala Leu Leu Met Ala Trp Phe Gly Val Leu 
1               5                   10                  15      


Ser Cys Val Gln Ala Glu Phe Phe Thr Ser Ile Gly His Met Thr Asp 
            20                  25                  30          


Leu Ile Tyr Ala Glu Lys Glu Leu Val Gln Ser Leu Lys Glu Tyr Ile 
        35                  40                  45              


Leu Val Glu Glu Ala Lys Leu Ser Lys Ile Lys Ser Trp Ala Asn Lys 
    50                  55                  60                  


Met Glu Ala Leu Thr Ser Lys Ser Ala Ala Asp Ala Glu Gly Tyr Leu 
65                  70                  75                  80  


Ala His Pro Val Asn Ala Tyr Lys Leu Val Lys Arg Leu Asn Thr Asp 
                85                  90                  95      


Trp Pro Ala Leu Glu Asp Leu Val Leu Gln Asp Ser Ala Ala Gly Phe 
            100                 105                 110         


Ile Ala 
        


<210>  9925
<211>  147
<212>  PRT
<213>  Homo Sapiens

<400>  9925

Met Lys Leu Trp Val Ser Ala Leu Leu Met Ala Trp Phe Gly Val Leu 
1               5                   10                  15      


Ser Cys Val Gln Ala Glu Phe Phe Thr Ser Ile Gly His Met Thr Asp 
            20                  25                  30          


Leu Ile Tyr Ala Glu Lys Glu Leu Val Gln Ser Leu Lys Glu Tyr Ile 
        35                  40                  45              


Leu Val Glu Glu Ala Lys Leu Ser Lys Ile Lys Ser Trp Ala Asn Lys 
    50                  55                  60                  


Met Glu Ala Leu Thr Ser Lys Ser Ala Ala Asp Ala Glu Gly Tyr Leu 
65                  70                  75                  80  


Ala His Pro Val Asn Ala Tyr Lys Leu Val Lys Arg Leu Asn Thr Asp 
                85                  90                  95      


Trp Pro Ala Leu Glu Asp Leu Val Leu Gln Asp Ser Ala Ala Gly Phe 
            100                 105                 110         


Ile Ala Asn Leu Ser Val Gln Arg Gln Phe Phe Pro Thr Asp Glu Asp 
        115                 120                 125             


Glu Ile Gly Ala Ala Lys Ala Leu Met Arg Leu Gln Asp Thr Tyr Arg 
    130                 135                 140                 


Leu Asp Pro 
145         


<210>  9926
<211>  153
<212>  PRT
<213>  Homo Sapiens

<400>  9926

Met Lys Leu Trp Val Ser Ala Leu Leu Met Ala Trp Phe Gly Val Leu 
1               5                   10                  15      


Ser Cys Val Gln Ala Glu Phe Phe Thr Ser Ile Gly His Met Thr Asp 
            20                  25                  30          


Leu Ile Tyr Ala Glu Lys Glu Leu Val Gln Ser Leu Lys Glu Tyr Ile 
        35                  40                  45              


Leu Val Glu Glu Ala Lys Leu Ser Lys Ile Lys Ser Trp Ala Asn Lys 
    50                  55                  60                  


Met Glu Ala Leu Thr Ser Lys Ser Ala Ala Asp Ala Glu Gly Tyr Leu 
65                  70                  75                  80  


Ala His Pro Val Asn Ala Tyr Lys Leu Val Lys Arg Leu Asn Thr Asp 
                85                  90                  95      


Trp Pro Ala Leu Glu Asp Leu Val Leu Gln Asp Ser Ala Ala Gly Phe 
            100                 105                 110         


Ile Ala Asn Leu Ser Val Gln Arg Gln Phe Phe Pro Thr Asp Glu Asp 
        115                 120                 125             


Glu Ile Gly Ala Ala Lys Ala Leu Met Arg Leu Gln Asp Thr Tyr Arg 
    130                 135                 140                 


Leu Asp Pro Gly Thr Ile Ser Arg Gly 
145                 150             


<210>  9927
<211>  167
<212>  PRT
<213>  Homo Sapiens

<400>  9927

Met Lys Leu Trp Val Ser Ala Leu Leu Met Ala Trp Phe Gly Val Leu 
1               5                   10                  15      


Ser Cys Val Gln Ala Glu Phe Phe Thr Ser Ile Gly His Met Thr Asp 
            20                  25                  30          


Leu Ile Tyr Ala Glu Lys Glu Leu Val Gln Ser Leu Lys Glu Tyr Ile 
        35                  40                  45              


Leu Val Glu Glu Ala Lys Leu Ser Lys Ile Lys Ser Trp Ala Asn Lys 
    50                  55                  60                  


Met Glu Ala Leu Thr Ser Lys Ser Ala Ala Asp Ala Glu Gly Tyr Leu 
65                  70                  75                  80  


Ala His Pro Val Asn Ala Tyr Lys Leu Val Lys Arg Leu Asn Thr Asp 
                85                  90                  95      


Trp Pro Ala Leu Glu Asp Leu Val Leu Gln Asp Ser Ala Ala Gly Phe 
            100                 105                 110         


Ile Ala Asn Leu Ser Val Gln Arg Gln Phe Phe Pro Thr Asp Glu Asp 
        115                 120                 125             


Glu Ile Gly Ala Ala Lys Ala Leu Met Arg Leu Gln Asp Thr Tyr Arg 
    130                 135                 140                 


Leu Asp Pro Gly Thr Ile Ser Arg Gly Glu Leu Pro Gly Thr Lys Tyr 
145                 150                 155                 160 


Gln Ala Met Leu Ser Val Asp 
                165         


<210>  9928
<211>  184
<212>  PRT
<213>  Homo Sapiens

<400>  9928

Met Lys Leu Trp Val Ser Ala Leu Leu Met Ala Trp Phe Gly Val Leu 
1               5                   10                  15      


Ser Cys Val Gln Ala Glu Phe Phe Thr Ser Ile Gly His Met Thr Asp 
            20                  25                  30          


Leu Ile Tyr Ala Glu Lys Glu Leu Val Gln Ser Leu Lys Glu Tyr Ile 
        35                  40                  45              


Leu Val Glu Glu Ala Lys Leu Ser Lys Ile Lys Ser Trp Ala Asn Lys 
    50                  55                  60                  


Met Glu Ala Leu Thr Ser Lys Ser Ala Ala Asp Ala Glu Gly Tyr Leu 
65                  70                  75                  80  


Ala His Pro Val Asn Ala Tyr Lys Leu Val Lys Arg Leu Asn Thr Asp 
                85                  90                  95      


Trp Pro Ala Leu Glu Asp Leu Val Leu Gln Asp Ser Ala Ala Gly Phe 
            100                 105                 110         


Ile Ala Asn Leu Ser Val Gln Arg Gln Phe Phe Pro Thr Asp Glu Asp 
        115                 120                 125             


Glu Ile Gly Ala Ala Lys Ala Leu Met Arg Leu Gln Asp Thr Tyr Arg 
    130                 135                 140                 


Leu Asp Pro Gly Thr Ile Ser Arg Gly Glu Leu Pro Gly Thr Lys Tyr 
145                 150                 155                 160 


Gln Ala Met Leu Ser Val Asp Asp Cys Phe Gly Met Gly Arg Ser Ala 
                165                 170                 175     


Tyr Asn Glu Gly Asp Tyr Tyr His 
            180                 


<210>  9929
<211>  204
<212>  PRT
<213>  Homo Sapiens

<400>  9929

Met Lys Leu Trp Val Ser Ala Leu Leu Met Ala Trp Phe Gly Val Leu 
1               5                   10                  15      


Ser Cys Val Gln Ala Glu Phe Phe Thr Ser Ile Gly His Met Thr Asp 
            20                  25                  30          


Leu Ile Tyr Ala Glu Lys Glu Leu Val Gln Ser Leu Lys Glu Tyr Ile 
        35                  40                  45              


Leu Val Glu Glu Ala Lys Leu Ser Lys Ile Lys Ser Trp Ala Asn Lys 
    50                  55                  60                  


Met Glu Ala Leu Thr Ser Lys Ser Ala Ala Asp Ala Glu Gly Tyr Leu 
65                  70                  75                  80  


Ala His Pro Val Asn Ala Tyr Lys Leu Val Lys Arg Leu Asn Thr Asp 
                85                  90                  95      


Trp Pro Ala Leu Glu Asp Leu Val Leu Gln Asp Ser Ala Ala Gly Phe 
            100                 105                 110         


Ile Ala Asn Leu Ser Val Gln Arg Gln Phe Phe Pro Thr Asp Glu Asp 
        115                 120                 125             


Glu Ile Gly Ala Ala Lys Ala Leu Met Arg Leu Gln Asp Thr Tyr Arg 
    130                 135                 140                 


Leu Asp Pro Gly Thr Ile Ser Arg Gly Glu Leu Pro Gly Thr Lys Tyr 
145                 150                 155                 160 


Gln Ala Met Leu Ser Val Asp Asp Cys Phe Gly Met Gly Arg Ser Ala 
                165                 170                 175     


Tyr Asn Glu Gly Asp Tyr Tyr His Thr Val Leu Trp Met Glu Gln Val 
            180                 185                 190         


Leu Lys Gln Leu Asp Ala Gly Glu Glu Ala Thr Thr 
        195                 200                 


<210>  9930
<211>  535
<212>  PRT
<213>  Homo Sapiens

<400>  9930

Met Lys Leu Trp Val Ser Ala Leu Leu Met Ala Trp Phe Gly Val Leu 
1               5                   10                  15      


Ser Cys Val Gln Ala Glu Phe Phe Thr Ser Ile Gly His Met Thr Asp 
            20                  25                  30          


Leu Ile Tyr Ala Glu Lys Glu Leu Val Gln Ser Leu Lys Glu Tyr Ile 
        35                  40                  45              


Leu Val Glu Glu Ala Lys Leu Ser Lys Ile Lys Ser Trp Ala Asn Lys 
    50                  55                  60                  


Met Glu Ala Leu Thr Ser Lys Ser Ala Ala Asp Ala Glu Gly Tyr Leu 
65                  70                  75                  80  


Ala His Pro Val Asn Ala Tyr Lys Leu Val Lys Arg Leu Asn Thr Asp 
                85                  90                  95      


Trp Pro Ala Leu Glu Asp Leu Val Leu Gln Asp Ser Ala Ala Gly Phe 
            100                 105                 110         


Ile Ala Asn Leu Ser Val Gln Arg Gln Phe Phe Pro Thr Asp Glu Asp 
        115                 120                 125             


Glu Ile Gly Ala Ala Lys Ala Leu Met Arg Leu Gln Asp Thr Tyr Arg 
    130                 135                 140                 


Leu Asp Pro Gly Thr Ile Ser Arg Gly Glu Leu Pro Gly Thr Lys Tyr 
145                 150                 155                 160 


Gln Ala Met Leu Ser Val Asp Asp Cys Phe Gly Met Gly Arg Ser Ala 
                165                 170                 175     


Tyr Asn Glu Gly Asp Tyr Tyr His Thr Val Leu Trp Met Glu Gln Val 
            180                 185                 190         


Leu Lys Gln Leu Asp Ala Gly Glu Glu Ala Thr Thr Thr Lys Ser Gln 
        195                 200                 205             


Val Leu Asp Tyr Leu Ser Tyr Ala Val Phe Gln Leu Gly Asp Leu His 
    210                 215                 220                 


Arg Ala Leu Glu Leu Thr Arg Arg Leu Leu Ser Leu Asp Pro Ser His 
225                 230                 235                 240 


Glu Arg Ala Gly Gly Asn Leu Arg Tyr Phe Glu Gln Leu Leu Glu Glu 
                245                 250                 255     


Glu Arg Glu Lys Thr Leu Thr Asn Gln Thr Glu Ala Glu Leu Ala Thr 
            260                 265                 270         


Pro Glu Gly Ile Tyr Glu Arg Pro Val Asp Tyr Leu Pro Glu Arg Asp 
        275                 280                 285             


Val Tyr Glu Ser Leu Cys Arg Gly Glu Gly Val Lys Leu Thr Pro Arg 
    290                 295                 300                 


Arg Gln Lys Arg Leu Phe Cys Arg Tyr His His Gly Asn Arg Ala Pro 
305                 310                 315                 320 


Gln Leu Leu Ile Ala Pro Phe Lys Glu Glu Asp Glu Trp Asp Ser Pro 
                325                 330                 335     


His Ile Val Arg Tyr Tyr Asp Val Met Ser Asp Glu Glu Ile Glu Arg 
            340                 345                 350         


Ile Lys Glu Ile Ala Lys Pro Lys Leu Ala Arg Ala Thr Val Arg Asp 
        355                 360                 365             


Pro Lys Thr Gly Val Leu Thr Val Ala Ser Tyr Arg Val Ser Lys Ser 
    370                 375                 380                 


Ser Trp Leu Glu Glu Asp Asp Asp Pro Val Val Ala Arg Val Asn Arg 
385                 390                 395                 400 


Arg Met Gln His Ile Thr Gly Leu Thr Val Lys Thr Ala Glu Leu Leu 
                405                 410                 415     


Gln Val Ala Asn Tyr Gly Val Gly Gly Gln Tyr Glu Pro His Phe Asp 
            420                 425                 430         


Phe Ser Arg Asn Asp Glu Arg Asp Thr Phe Lys His Leu Gly Thr Gly 
        435                 440                 445             


Asn Arg Val Ala Thr Phe Leu Asn Tyr Met Ser Asp Val Glu Ala Gly 
    450                 455                 460                 


Gly Ala Thr Val Phe Pro Asp Leu Gly Ala Ala Ile Trp Pro Lys Lys 
465                 470                 475                 480 


Gly Thr Ala Val Phe Trp Tyr Asn Leu Leu Arg Ser Gly Glu Gly Asp 
                485                 490                 495     


Tyr Arg Thr Arg His Ala Ala Cys Pro Val Leu Val Gly Cys Lys Trp 
            500                 505                 510         


Val Ser Asn Lys Trp Phe His Glu Arg Gly Gln Glu Phe Leu Arg Pro 
        515                 520                 525             


Cys Gly Ser Thr Glu Val Asp 
    530                 535 


<210>  9931
<211>  533
<212>  PRT
<213>  Homo Sapiens

<400>  9931

Met Lys Leu Trp Val Ser Ala Leu Leu Met Ala Trp Phe Gly Val Leu 
1               5                   10                  15      


Ser Cys Val Gln Ala Glu Phe Phe Thr Ser Ile Gly His Met Thr Asp 
            20                  25                  30          


Leu Ile Tyr Ala Glu Lys Glu Leu Val Gln Ser Leu Lys Glu Tyr Ile 
        35                  40                  45              


Leu Val Glu Glu Ala Lys Leu Ser Lys Ile Lys Ser Trp Ala Asn Lys 
    50                  55                  60                  


Met Glu Ala Leu Thr Ser Lys Ser Ala Ala Asp Ala Glu Gly Tyr Leu 
65                  70                  75                  80  


Ala His Pro Val Asn Ala Tyr Lys Leu Val Lys Arg Leu Asn Thr Asp 
                85                  90                  95      


Trp Pro Ala Leu Glu Asp Leu Val Leu Gln Asp Ser Ala Ala Gly Phe 
            100                 105                 110         


Ile Ala Asn Leu Ser Val Gln Arg Gln Phe Phe Pro Thr Asp Glu Asp 
        115                 120                 125             


Glu Ile Gly Ala Ala Lys Ala Leu Met Arg Leu Gln Asp Thr Tyr Arg 
    130                 135                 140                 


Leu Asp Pro Gly Thr Ile Ser Arg Gly Glu Leu Pro Gly Thr Lys Tyr 
145                 150                 155                 160 


Gln Ala Met Leu Ser Val Asp Asp Cys Phe Gly Met Gly Arg Ser Ala 
                165                 170                 175     


Tyr Asn Glu Gly Asp Tyr Tyr His Thr Val Leu Trp Met Glu Gln Val 
            180                 185                 190         


Leu Lys Gln Leu Asp Ala Gly Glu Glu Ala Thr Thr Thr Lys Ser Gln 
        195                 200                 205             


Val Leu Asp Tyr Leu Ser Tyr Ala Val Phe Gln Leu Gly Asp Leu His 
    210                 215                 220                 


Arg Ala Leu Glu Leu Thr Arg Arg Leu Leu Ser Leu Asp Pro Ser His 
225                 230                 235                 240 


Glu Arg Ala Gly Gly Asn Leu Arg Tyr Phe Glu Gln Leu Leu Glu Glu 
                245                 250                 255     


Glu Arg Glu Lys Thr Leu Thr Asn Gln Thr Glu Ala Glu Leu Ala Thr 
            260                 265                 270         


Pro Glu Gly Ile Tyr Glu Arg Pro Val Asp Tyr Leu Pro Glu Arg Asp 
        275                 280                 285             


Val Tyr Glu Ser Leu Cys Arg Gly Glu Gly Val Lys Leu Thr Pro Arg 
    290                 295                 300                 


Arg Gln Lys Arg Leu Phe Cys Arg Tyr His His Gly Asn Arg Ala Pro 
305                 310                 315                 320 


Gln Leu Leu Ile Ala Pro Phe Lys Glu Glu Asp Glu Trp Asp Ser Pro 
                325                 330                 335     


His Ile Val Arg Tyr Tyr Asp Val Met Ser Asp Glu Glu Ile Glu Arg 
            340                 345                 350         


Ile Lys Glu Ile Ala Lys Pro Lys Leu Ala Arg Ala Thr Val Arg Asp 
        355                 360                 365             


Pro Lys Thr Gly Val Leu Thr Val Ala Ser Tyr Arg Val Ser Lys Ser 
    370                 375                 380                 


Ser Trp Leu Glu Glu Asp Asp Asp Pro Val Val Ala Arg Val Asn Arg 
385                 390                 395                 400 


Arg Met Gln His Ile Thr Gly Leu Thr Val Lys Thr Ala Glu Leu Leu 
                405                 410                 415     


Gln Val Ala Asn Tyr Gly Val Gly Gly Gln Tyr Glu Pro His Phe Asp 
            420                 425                 430         


Phe Ser Arg Arg Pro Phe Asp Ser Gly Leu Lys Thr Glu Gly Asn Arg 
        435                 440                 445             


Leu Ala Thr Phe Leu Asn Tyr Met Ser Asp Val Glu Ala Gly Gly Ala 
    450                 455                 460                 


Thr Val Phe Pro Asp Leu Gly Ala Ala Ile Trp Pro Lys Lys Gly Thr 
465                 470                 475                 480 


Ala Val Phe Trp Tyr Asn Leu Leu Arg Ser Gly Glu Gly Asp Tyr Arg 
                485                 490                 495     


Thr Arg His Ala Ala Cys Pro Val Leu Val Gly Cys Lys Trp Val Ser 
            500                 505                 510         


Asn Lys Trp Phe His Glu Arg Gly Gln Glu Phe Leu Arg Pro Cys Gly 
        515                 520                 525             


Ser Thr Glu Val Asp 
    530             


<210>  9932
<211>  533
<212>  PRT
<213>  Homo Sapiens

<400>  9932

Met Lys Leu Trp Val Ser Ala Leu Leu Met Ala Trp Phe Gly Val Leu 
1               5                   10                  15      


Ser Cys Val Gln Ala Glu Phe Phe Thr Ser Ile Gly His Met Thr Asp 
            20                  25                  30          


Leu Ile Tyr Ala Glu Lys Glu Leu Val Gln Ser Leu Lys Glu Tyr Ile 
        35                  40                  45              


Leu Val Glu Glu Ala Lys Leu Ser Lys Ile Lys Ser Trp Ala Asn Lys 
    50                  55                  60                  


Met Glu Ala Leu Thr Ser Lys Ser Ala Ala Asp Ala Glu Gly Tyr Leu 
65                  70                  75                  80  


Ala His Pro Val Asn Ala Tyr Lys Leu Val Lys Arg Leu Asn Thr Asp 
                85                  90                  95      


Trp Pro Ala Leu Glu Asp Leu Val Leu Gln Asp Ser Ala Ala Gly Phe 
            100                 105                 110         


Ile Ala Asn Leu Ser Val Gln Arg Gln Phe Phe Pro Thr Asp Glu Asp 
        115                 120                 125             


Glu Ile Gly Ala Ala Lys Ala Leu Met Arg Leu Gln Asp Thr Tyr Arg 
    130                 135                 140                 


Leu Asp Pro Gly Thr Ile Ser Arg Gly Glu Leu Pro Gly Thr Lys Tyr 
145                 150                 155                 160 


Gln Ala Met Leu Ser Val Asp Asp Cys Phe Gly Met Gly Arg Ser Ala 
                165                 170                 175     


Tyr Asn Glu Gly Asp Tyr Tyr His Thr Val Leu Trp Met Glu Gln Val 
            180                 185                 190         


Leu Lys Gln Leu Asp Ala Gly Glu Glu Ala Thr Thr Thr Lys Ser Gln 
        195                 200                 205             


Val Leu Asp Tyr Leu Ser Tyr Ala Val Phe Gln Leu Gly Asp Leu His 
    210                 215                 220                 


Arg Ala Leu Glu Leu Thr Arg Arg Leu Leu Ser Leu Asp Pro Ser His 
225                 230                 235                 240 


Glu Arg Ala Gly Gly Asn Leu Arg Tyr Phe Glu Gln Leu Leu Glu Glu 
                245                 250                 255     


Glu Arg Glu Lys Thr Leu Thr Asn Gln Thr Glu Ala Glu Leu Ala Thr 
            260                 265                 270         


Pro Glu Gly Ile Tyr Glu Arg Pro Val Asp Tyr Leu Pro Glu Arg Asp 
        275                 280                 285             


Val Tyr Glu Ser Leu Cys Arg Gly Glu Gly Val Lys Leu Thr Pro Arg 
    290                 295                 300                 


Arg Gln Lys Arg Leu Phe Cys Arg Tyr His His Gly Asn Arg Ala Pro 
305                 310                 315                 320 


Gln Leu Leu Ile Ala Pro Phe Lys Glu Glu Asp Glu Trp Asp Ser Pro 
                325                 330                 335     


His Ile Val Arg Tyr Tyr Asp Val Met Ser Asp Glu Glu Ile Glu Arg 
            340                 345                 350         


Ile Lys Glu Ile Ala Lys Pro Lys Leu Ala Arg Ala Thr Val Arg Asp 
        355                 360                 365             


Pro Lys Thr Gly Val Leu Thr Val Ala Ser Tyr Arg Val Ser Lys Ser 
    370                 375                 380                 


Ser Trp Leu Glu Glu Asp Asp Asp Pro Val Val Ala Arg Val Asn Arg 
385                 390                 395                 400 


Arg Met Gln His Ile Thr Gly Leu Thr Val Lys Thr Ala Glu Leu Leu 
                405                 410                 415     


Gln Val Ala Asn Tyr Gly Val Gly Gly Gln Tyr Glu Pro His Phe Asp 
            420                 425                 430         


Phe Ser Arg Arg Pro Phe Asp Ser Gly Leu Lys Thr Glu Gly Asn Arg 
        435                 440                 445             


Leu Ala Thr Phe Leu Asn Tyr Met Ser Asp Val Glu Ala Gly Gly Ala 
    450                 455                 460                 


Thr Val Phe Pro Asp Leu Gly Ala Ala Ile Trp Pro Lys Lys Gly Thr 
465                 470                 475                 480 


Ala Val Phe Trp Tyr Asn Leu Leu Arg Ser Gly Glu Gly Asp Tyr Arg 
                485                 490                 495     


Thr Arg His Ala Ala Cys Pro Val Leu Val Gly Cys Lys Trp Val Ser 
            500                 505                 510         


Asn Lys Trp Phe His Glu Arg Gly Gln Glu Phe Leu Arg Pro Cys Gly 
        515                 520                 525             


Ser Thr Glu Val Asp 
    530             


<210>  9933
<211>  533
<212>  PRT
<213>  Homo Sapiens

<400>  9933

Met Lys Leu Trp Val Ser Ala Leu Leu Met Ala Trp Phe Gly Val Leu 
1               5                   10                  15      


Ser Cys Val Gln Ala Glu Phe Phe Thr Ser Ile Gly His Met Thr Asp 
            20                  25                  30          


Leu Ile Tyr Ala Glu Lys Glu Leu Val Gln Ser Leu Lys Glu Tyr Ile 
        35                  40                  45              


Leu Val Glu Glu Ala Lys Leu Ser Lys Ile Lys Ser Trp Ala Asn Lys 
    50                  55                  60                  


Met Glu Ala Leu Thr Ser Lys Ser Ala Ala Asp Ala Glu Gly Tyr Leu 
65                  70                  75                  80  


Ala His Pro Val Asn Ala Tyr Lys Leu Val Lys Arg Leu Asn Thr Asp 
                85                  90                  95      


Trp Pro Ala Leu Glu Asp Leu Val Leu Gln Asp Ser Ala Ala Gly Phe 
            100                 105                 110         


Ile Ala Asn Leu Ser Val Gln Arg Gln Phe Phe Pro Thr Asp Glu Asp 
        115                 120                 125             


Glu Ile Gly Ala Ala Lys Ala Leu Met Arg Leu Gln Asp Thr Tyr Arg 
    130                 135                 140                 


Leu Asp Pro Gly Thr Ile Ser Arg Gly Glu Leu Pro Gly Thr Lys Tyr 
145                 150                 155                 160 


Gln Ala Met Leu Ser Val Asp Asp Cys Phe Gly Met Gly Arg Ser Ala 
                165                 170                 175     


Tyr Asn Glu Gly Asp Tyr Tyr His Thr Val Leu Trp Met Glu Gln Val 
            180                 185                 190         


Leu Lys Gln Leu Asp Ala Gly Glu Glu Ala Thr Thr Thr Lys Ser Gln 
        195                 200                 205             


Val Leu Asp Tyr Leu Ser Tyr Ala Val Phe Gln Leu Gly Asp Leu His 
    210                 215                 220                 


Arg Ala Leu Glu Leu Thr Arg Arg Leu Leu Ser Leu Asp Pro Ser His 
225                 230                 235                 240 


Glu Arg Ala Gly Gly Asn Leu Arg Tyr Phe Glu Gln Leu Leu Glu Glu 
                245                 250                 255     


Glu Arg Glu Lys Thr Leu Thr Asn Gln Thr Glu Ala Glu Leu Ala Thr 
            260                 265                 270         


Pro Glu Gly Ile Tyr Glu Arg Pro Val Asp Tyr Leu Pro Glu Arg Asp 
        275                 280                 285             


Val Tyr Glu Ser Leu Cys Arg Gly Glu Gly Val Lys Leu Thr Pro Arg 
    290                 295                 300                 


Arg Gln Lys Arg Leu Phe Cys Arg Tyr His His Gly Asn Arg Ala Pro 
305                 310                 315                 320 


Gln Leu Leu Ile Ala Pro Phe Lys Glu Glu Asp Glu Trp Asp Ser Pro 
                325                 330                 335     


His Ile Val Arg Tyr Tyr Asp Val Met Ser Asp Glu Glu Ile Glu Arg 
            340                 345                 350         


Ile Lys Glu Ile Ala Lys Pro Lys Leu Ala Arg Ala Thr Val Arg Asp 
        355                 360                 365             


Pro Lys Thr Gly Val Leu Thr Val Ala Ser Tyr Arg Val Ser Lys Ser 
    370                 375                 380                 


Ser Trp Leu Glu Glu Asp Asp Asp Pro Val Val Ala Arg Val Asn Arg 
385                 390                 395                 400 


Arg Met Gln His Ile Thr Gly Leu Thr Val Lys Thr Ala Glu Leu Leu 
                405                 410                 415     


Gln Val Ala Asn Tyr Gly Val Gly Gly Gln Tyr Glu Pro His Phe Asp 
            420                 425                 430         


Phe Ser Arg Arg Pro Phe Asp Ser Gly Leu Lys Thr Glu Gly Asn Arg 
        435                 440                 445             


Leu Ala Thr Phe Leu Asn Tyr Met Ser Asp Val Glu Ala Gly Gly Ala 
    450                 455                 460                 


Thr Val Phe Pro Asp Leu Gly Ala Ala Ile Trp Pro Lys Lys Gly Thr 
465                 470                 475                 480 


Ala Val Phe Trp Tyr Asn Leu Leu Arg Ser Gly Glu Gly Asp Tyr Arg 
                485                 490                 495     


Thr Arg His Ala Ala Cys Pro Val Leu Val Gly Cys Lys Trp Val Ser 
            500                 505                 510         


Asn Lys Trp Phe His Glu Arg Gly Gln Glu Phe Leu Arg Pro Cys Gly 
        515                 520                 525             


Ser Thr Glu Val Asp 
    530             


<210>  9934
<211>  535
<212>  PRT
<213>  Homo Sapiens

<400>  9934

Met Lys Leu Trp Val Ser Ala Leu Leu Met Ala Trp Phe Gly Val Leu 
1               5                   10                  15      


Ser Cys Val Gln Ala Glu Phe Phe Thr Ser Ile Gly His Met Thr Asp 
            20                  25                  30          


Leu Ile Tyr Ala Glu Lys Glu Leu Val Gln Ser Leu Lys Glu Tyr Ile 
        35                  40                  45              


Leu Val Glu Glu Ala Lys Leu Ser Lys Ile Lys Ser Trp Ala Asn Lys 
    50                  55                  60                  


Met Glu Ala Leu Thr Ser Lys Ser Ala Ala Asp Ala Glu Gly Tyr Leu 
65                  70                  75                  80  


Ala His Pro Val Asn Ala Tyr Lys Leu Val Lys Arg Leu Asn Thr Asp 
                85                  90                  95      


Trp Pro Ala Leu Glu Asp Leu Val Leu Gln Asp Ser Ala Ala Gly Phe 
            100                 105                 110         


Ile Ala Asn Leu Ser Val Gln Arg Gln Phe Phe Pro Thr Asp Glu Asp 
        115                 120                 125             


Glu Ile Gly Ala Ala Lys Ala Leu Met Arg Leu Gln Asp Thr Tyr Arg 
    130                 135                 140                 


Leu Asp Pro Gly Thr Ile Ser Arg Gly Glu Leu Pro Gly Thr Lys Tyr 
145                 150                 155                 160 


Gln Ala Met Leu Ser Val Asp Asp Cys Phe Gly Met Gly Arg Ser Ala 
                165                 170                 175     


Tyr Asn Glu Gly Asp Tyr Tyr His Thr Val Leu Trp Met Glu Gln Val 
            180                 185                 190         


Leu Lys Gln Leu Asp Ala Gly Glu Glu Ala Thr Thr Thr Lys Ser Gln 
        195                 200                 205             


Val Leu Asp Tyr Leu Ser Tyr Ala Val Phe Gln Leu Gly Asp Leu His 
    210                 215                 220                 


Arg Ala Leu Glu Leu Thr Arg Arg Leu Leu Ser Leu Asp Pro Ser His 
225                 230                 235                 240 


Glu Arg Ala Gly Gly Asn Leu Arg Tyr Phe Glu Gln Leu Leu Glu Glu 
                245                 250                 255     


Glu Arg Glu Lys Thr Leu Thr Asn Gln Thr Glu Ala Glu Leu Ala Thr 
            260                 265                 270         


Pro Glu Gly Ile Tyr Glu Arg Pro Val Asp Tyr Leu Pro Glu Arg Asp 
        275                 280                 285             


Val Tyr Glu Ser Leu Cys Arg Gly Glu Gly Val Lys Leu Thr Pro Arg 
    290                 295                 300                 


Arg Gln Lys Arg Leu Phe Cys Arg Tyr His His Gly Asn Arg Ala Pro 
305                 310                 315                 320 


Gln Leu Leu Ile Ala Pro Phe Lys Glu Glu Asp Glu Trp Asp Ser Pro 
                325                 330                 335     


His Ile Val Arg Tyr Tyr Asp Val Met Ser Asp Glu Glu Ile Glu Arg 
            340                 345                 350         


Ile Lys Glu Ile Ala Lys Pro Lys Leu Ala Arg Ala Thr Val Arg Asp 
        355                 360                 365             


Pro Lys Thr Gly Val Leu Thr Val Ala Ser Tyr Arg Val Ser Lys Ser 
    370                 375                 380                 


Ser Trp Leu Glu Glu Asp Asp Asp Pro Val Val Ala Arg Val Asn Arg 
385                 390                 395                 400 


Arg Met Gln His Ile Thr Gly Leu Thr Val Lys Thr Ala Glu Leu Leu 
                405                 410                 415     


Gln Val Ala Asn Tyr Gly Val Gly Gly Gln Tyr Glu Pro His Phe Asp 
            420                 425                 430         


Phe Ser Arg Asn Asp Glu Arg Asp Thr Phe Lys His Leu Gly Thr Gly 
        435                 440                 445             


Asn Arg Val Ala Thr Phe Leu Asn Tyr Met Ser Asp Val Glu Ala Gly 
    450                 455                 460                 


Gly Ala Thr Val Phe Pro Asp Leu Gly Ala Ala Ile Trp Pro Lys Lys 
465                 470                 475                 480 


Gly Thr Ala Val Phe Trp Tyr Asn Leu Leu Arg Ser Gly Glu Gly Asp 
                485                 490                 495     


Tyr Arg Thr Arg His Ala Ala Cys Pro Val Leu Val Gly Cys Lys Trp 
            500                 505                 510         


Val Ser Asn Lys Trp Phe His Glu Arg Gly Gln Glu Phe Leu Arg Pro 
        515                 520                 525             


Cys Gly Ser Thr Glu Val Asp 
    530                 535 


<210>  9935
<211>  535
<212>  PRT
<213>  Homo Sapiens

<400>  9935

Met Lys Leu Trp Val Ser Ala Leu Leu Met Ala Trp Phe Gly Val Leu 
1               5                   10                  15      


Ser Cys Val Gln Ala Glu Phe Phe Thr Ser Ile Gly His Met Thr Asp 
            20                  25                  30          


Leu Ile Tyr Ala Glu Lys Glu Leu Val Gln Ser Leu Lys Glu Tyr Ile 
        35                  40                  45              


Leu Val Glu Glu Ala Lys Leu Ser Lys Ile Lys Ser Trp Ala Asn Lys 
    50                  55                  60                  


Met Glu Ala Leu Thr Ser Lys Ser Ala Ala Asp Ala Glu Gly Tyr Leu 
65                  70                  75                  80  


Ala His Pro Val Asn Ala Tyr Lys Leu Val Lys Arg Leu Asn Thr Asp 
                85                  90                  95      


Trp Pro Ala Leu Glu Asp Leu Val Leu Gln Asp Ser Ala Ala Gly Phe 
            100                 105                 110         


Ile Ala Asn Leu Ser Val Gln Arg Gln Phe Phe Pro Thr Asp Glu Asp 
        115                 120                 125             


Glu Ile Gly Ala Ala Lys Ala Leu Met Arg Leu Gln Asp Thr Tyr Arg 
    130                 135                 140                 


Leu Asp Pro Gly Thr Ile Ser Arg Gly Glu Leu Pro Gly Thr Lys Tyr 
145                 150                 155                 160 


Gln Ala Met Leu Ser Val Asp Asp Cys Phe Gly Met Gly Arg Ser Ala 
                165                 170                 175     


Tyr Asn Glu Gly Asp Tyr Tyr His Thr Val Leu Trp Met Glu Gln Val 
            180                 185                 190         


Leu Lys Gln Leu Asp Ala Gly Glu Glu Ala Thr Thr Thr Lys Ser Gln 
        195                 200                 205             


Val Leu Asp Tyr Leu Ser Tyr Ala Val Phe Gln Leu Gly Asp Leu His 
    210                 215                 220                 


Arg Ala Leu Glu Leu Thr Arg Arg Leu Leu Ser Leu Asp Pro Ser His 
225                 230                 235                 240 


Glu Arg Ala Gly Gly Asn Leu Arg Tyr Phe Glu Gln Leu Leu Glu Glu 
                245                 250                 255     


Glu Arg Glu Lys Thr Leu Thr Asn Gln Thr Glu Ala Glu Leu Ala Thr 
            260                 265                 270         


Pro Glu Gly Ile Tyr Glu Arg Pro Val Asp Tyr Leu Pro Glu Arg Asp 
        275                 280                 285             


Val Tyr Glu Ser Leu Cys Arg Gly Glu Gly Val Lys Leu Thr Pro Arg 
    290                 295                 300                 


Arg Gln Lys Arg Leu Phe Cys Arg Tyr His His Gly Asn Arg Ala Pro 
305                 310                 315                 320 


Gln Leu Leu Ile Ala Pro Phe Lys Glu Glu Asp Glu Trp Asp Ser Pro 
                325                 330                 335     


His Ile Val Arg Tyr Tyr Asp Val Met Ser Asp Glu Glu Ile Glu Arg 
            340                 345                 350         


Ile Lys Glu Ile Ala Lys Pro Lys Leu Ala Arg Ala Thr Val Arg Asp 
        355                 360                 365             


Pro Lys Thr Gly Val Leu Thr Val Ala Ser Tyr Arg Val Ser Lys Ser 
    370                 375                 380                 


Ser Trp Leu Glu Glu Asp Asp Asp Pro Val Val Ala Arg Val Asn Arg 
385                 390                 395                 400 


Arg Met Gln His Ile Thr Gly Leu Thr Val Lys Thr Ala Glu Leu Leu 
                405                 410                 415     


Gln Val Ala Asn Tyr Gly Val Gly Gly Gln Tyr Glu Pro His Phe Asp 
            420                 425                 430         


Phe Ser Arg Asn Asp Glu Arg Asp Thr Phe Lys His Leu Gly Thr Gly 
        435                 440                 445             


Asn Arg Val Ala Thr Phe Leu Asn Tyr Met Ser Asp Val Glu Ala Gly 
    450                 455                 460                 


Gly Ala Thr Val Phe Pro Asp Leu Gly Ala Ala Ile Trp Pro Lys Lys 
465                 470                 475                 480 


Gly Thr Ala Val Phe Trp Tyr Asn Leu Leu Arg Ser Gly Glu Gly Asp 
                485                 490                 495     


Tyr Arg Thr Arg His Ala Ala Cys Pro Val Leu Val Gly Cys Lys Trp 
            500                 505                 510         


Val Ser Asn Lys Trp Phe His Glu Arg Gly Gln Glu Phe Leu Arg Pro 
        515                 520                 525             


Cys Gly Ser Thr Glu Val Asp 
    530                 535 


<210>  9936
<211>  236
<212>  PRT
<213>  Homo Sapiens

<400>  9936

Met Lys Arg Gln Leu Val Thr Asn Ser Phe Leu His His Leu Leu Ile 
1               5                   10                  15      


Gly Gln Lys Arg Pro Arg Asn Ala Pro Arg Thr Leu Pro Ser Val Thr 
            20                  25                  30          


Met Lys Leu Trp Val Ser Ala Leu Leu Met Ala Trp Phe Gly Val Leu 
        35                  40                  45              


Ser Cys Val Gln Ala Glu Phe Phe Thr Ser Ile Gly His Met Thr Asp 
    50                  55                  60                  


Leu Ile Tyr Ala Glu Lys Glu Leu Val Gln Ser Leu Lys Glu Tyr Ile 
65                  70                  75                  80  


Leu Val Glu Glu Ala Lys Leu Ser Lys Ile Lys Ser Trp Ala Asn Lys 
                85                  90                  95      


Met Glu Ala Leu Thr Ser Lys Ser Ala Ala Asp Ala Glu Gly Tyr Leu 
            100                 105                 110         


Ala His Pro Val Asn Ala Tyr Lys Leu Val Lys Arg Leu Asn Thr Asp 
        115                 120                 125             


Trp Pro Ala Leu Glu Asp Leu Val Leu Gln Asp Ser Ala Ala Gly Phe 
    130                 135                 140                 


Ile Ala Asn Leu Ser Val Gln Arg Gln Phe Phe Pro Thr Asp Glu Asp 
145                 150                 155                 160 


Glu Ile Gly Ala Ala Lys Ala Leu Met Arg Leu Gln Asp Thr Tyr Arg 
                165                 170                 175     


Leu Asp Pro Gly Thr Ile Ser Arg Gly Glu Leu Pro Gly Thr Lys Tyr 
            180                 185                 190         


Gln Ala Met Leu Ser Val Asp Asp Cys Phe Gly Met Gly Arg Ser Ala 
        195                 200                 205             


Tyr Asn Glu Gly Asp Tyr Tyr His Thr Val Leu Trp Met Glu Gln Val 
    210                 215                 220                 


Leu Lys Gln Leu Asp Ala Gly Glu Glu Ala Thr Thr 
225                 230                 235     


<210>  9937
<211>  104
<212>  PRT
<213>  Homo Sapiens

<400>  9937

Met Gly Pro Gly Ala Arg Leu Ala Ala Leu Leu Ala Val Leu Ala Leu 
1               5                   10                  15      


Gly Thr Gly Asp Pro Glu Arg Ala Ala Ala Arg Gly Asp Thr Phe Ser 
            20                  25                  30          


Ala Leu Thr Ser Val Ala Arg Ala Leu Ala Pro Glu Arg Arg Leu Leu 
        35                  40                  45              


Gly Leu Leu Arg Arg Tyr Leu Arg Gly Glu Glu Ala Arg Leu Arg Asp 
    50                  55                  60                  


Leu Thr Arg Phe Tyr Asp Lys Val Leu Ser Leu His Glu Asp Ser Thr 
65                  70                  75                  80  


Thr Pro Val Ala Asn Pro Leu Leu Ala Phe Thr Leu Ile Lys Arg Leu 
                85                  90                  95      


Gln Ser Asp Trp Arg Asn Val Leu 
            100                 


<210>  9938
<211>  544
<212>  PRT
<213>  Homo Sapiens

<400>  9938

Met Gly Pro Gly Ala Arg Leu Ala Ala Leu Leu Ala Val Leu Ala Leu 
1               5                   10                  15      


Gly Thr Gly Asp Pro Glu Arg Ala Ala Ala Arg Gly Asp Thr Phe Ser 
            20                  25                  30          


Ala Leu Thr Ser Val Ala Arg Ala Leu Ala Pro Glu Arg Arg Leu Leu 
        35                  40                  45              


Gly Leu Leu Arg Arg Tyr Leu Arg Gly Glu Glu Ala Arg Leu Arg Asp 
    50                  55                  60                  


Leu Thr Arg Phe Tyr Asp Lys Val Leu Ser Leu His Glu Asp Ser Thr 
65                  70                  75                  80  


Thr Pro Val Ala Asn Pro Leu Leu Ala Phe Thr Leu Ile Lys Arg Leu 
                85                  90                  95      


Gln Ser Asp Trp Arg Asn Val Val His Ser Leu Glu Ala Ser Glu Asn 
            100                 105                 110         


Ile Arg Ala Leu Lys Asp Gly Tyr Glu Lys Val Glu Gln Asp Leu Pro 
        115                 120                 125             


Ala Phe Glu Asp Leu Glu Gly Ala Ala Arg Ala Leu Met Arg Leu Gln 
    130                 135                 140                 


Asp Val Tyr Met Leu Asn Val Lys Gly Leu Ala Arg Gly Val Phe Gln 
145                 150                 155                 160 


Arg Val Thr Gly Ser Ala Ile Thr Asp Leu Tyr Ser Pro Lys Arg Leu 
                165                 170                 175     


Phe Ser Leu Thr Gly Asp Asp Cys Phe Gln Val Gly Lys Val Ala Tyr 
            180                 185                 190         


Asp Met Gly Asp Tyr Tyr His Ala Ile Pro Trp Leu Glu Glu Ala Val 
        195                 200                 205             


Ser Leu Phe Arg Gly Ser Tyr Gly Glu Trp Lys Thr Glu Asp Glu Ala 
    210                 215                 220                 


Ser Leu Glu Asp Ala Leu Asp His Leu Ala Phe Ala Tyr Phe Arg Ala 
225                 230                 235                 240 


Gly Asn Val Ser Cys Ala Leu Ser Leu Ser Arg Glu Phe Leu Leu Tyr 
                245                 250                 255     


Ser Pro Asp Asn Lys Arg Met Ala Arg Asn Val Leu Lys Tyr Glu Arg 
            260                 265                 270         


Leu Leu Ala Glu Ser Pro Asn His Val Val Ala Glu Ala Val Ile Gln 
        275                 280                 285             


Arg Pro Asn Ile Pro His Leu Gln Thr Arg Asp Thr Tyr Glu Gly Leu 
    290                 295                 300                 


Cys Gln Thr Leu Gly Ser Gln Pro Thr Leu Tyr Gln Ile Pro Ser Leu 
305                 310                 315                 320 


Tyr Cys Ser Tyr Glu Thr Asn Ser Asn Ala Tyr Leu Leu Leu Gln Pro 
                325                 330                 335     


Ile Arg Lys Glu Val Ile His Leu Glu Pro Tyr Ile Ala Leu Tyr His 
            340                 345                 350         


Asp Phe Val Ser Asp Ser Glu Ala Gln Lys Ile Arg Glu Leu Ala Glu 
        355                 360                 365             


Pro Trp Leu Gln Arg Ser Val Val Ala Ser Gly Glu Lys Gln Leu Gln 
    370                 375                 380                 


Val Glu Tyr Arg Ile Ser Lys Ser Ala Trp Leu Lys Asp Thr Val Asp 
385                 390                 395                 400 


Pro Lys Leu Val Thr Leu Asn His Arg Ile Ala Ala Leu Thr Gly Leu 
                405                 410                 415     


Asp Val Arg Pro Pro Tyr Ala Glu Tyr Leu Gln Val Val Asn Tyr Gly 
            420                 425                 430         


Ile Gly Gly His Tyr Glu Pro His Phe Asp His Ala Thr Ser Pro Ser 
        435                 440                 445             


Ser Pro Leu Tyr Arg Met Lys Ser Gly Asn Arg Val Ala Thr Phe Met 
    450                 455                 460                 


Ile Tyr Leu Ser Ser Val Glu Ala Gly Gly Ala Thr Ala Phe Ile Tyr 
465                 470                 475                 480 


Ala Asn Leu Ser Val Pro Val Val Arg Asn Ala Ala Leu Phe Trp Trp 
                485                 490                 495     


Asn Leu His Arg Ser Gly Glu Gly Asp Ser Asp Thr Leu His Ala Gly 
            500                 505                 510         


Cys Pro Val Leu Val Gly Asp Lys Trp Val Ala Asn Lys Trp Ile His 
        515                 520                 525             


Glu Tyr Gly Gln Glu Phe Arg Arg Pro Cys Ser Ser Ser Pro Glu Asp 
    530                 535                 540                 


<210>  9939
<211>  604
<212>  PRT
<213>  Homo Sapiens

<400>  9939

Met Gly Pro Gly Ala Arg Leu Ala Ala Leu Leu Ala Val Leu Ala Leu 
1               5                   10                  15      


Gly Thr Gly Asp Pro Glu Arg Ala Ala Ala Arg Gly Asp Thr Phe Ser 
            20                  25                  30          


Ala Leu Thr Ser Val Ala Arg Ala Leu Ala Pro Glu Arg Arg Leu Leu 
        35                  40                  45              


Gly Leu Leu Arg Arg Tyr Leu Arg Gly Glu Glu Ala Arg Leu Arg Asp 
    50                  55                  60                  


Leu Thr Arg Phe Tyr Asp Lys Val Leu Ser Leu His Glu Asp Ser Thr 
65                  70                  75                  80  


Thr Pro Val Ala Asn Pro Leu Leu Ala Phe Thr Leu Ile Lys Arg Leu 
                85                  90                  95      


Gln Ser Asp Trp Arg Asn Val Val His Ser Leu Glu Ala Ser Glu Asn 
            100                 105                 110         


Ile Arg Ala Leu Lys Asp Gly Tyr Glu Lys Val Glu Gln Asp Leu Pro 
        115                 120                 125             


Ala Phe Glu Asp Leu Glu Gly Ala Ala Arg Ala Leu Met Arg Leu Gln 
    130                 135                 140                 


Asp Val Tyr Met Leu Asn Val Lys Gly Leu Ala Arg Gly Val Phe Gln 
145                 150                 155                 160 


Arg Val Thr Gly Ser Ala Ile Thr Asp Leu Tyr Ser Pro Lys Arg Leu 
                165                 170                 175     


Phe Ser Leu Thr Gly Asp Asp Cys Phe Gln Val Gly Lys Val Ala Tyr 
            180                 185                 190         


Asp Met Gly Asp Tyr Tyr His Ala Ile Pro Trp Leu Glu Glu Ala Val 
        195                 200                 205             


Ser Leu Phe Arg Gly Ser Tyr Gly Glu Trp Lys Thr Glu Asp Glu Ala 
    210                 215                 220                 


Ser Leu Glu Asp Ala Leu Asp His Leu Ala Phe Ala Tyr Phe Arg Ala 
225                 230                 235                 240 


Gly Asn Val Ser Cys Ala Leu Ser Leu Ser Arg Glu Phe Leu Leu Tyr 
                245                 250                 255     


Ser Pro Asp Asn Lys Arg Met Ala Arg Asn Val Leu Lys Tyr Glu Arg 
            260                 265                 270         


Leu Leu Ala Glu Ser Pro Asn His Val Val Ala Glu Ala Val Ile Gln 
        275                 280                 285             


Arg Pro Asn Ile Pro His Leu Gln Thr Arg Asp Thr Tyr Glu Gly Leu 
    290                 295                 300                 


Cys Gln Thr Leu Gly Ser Gln Pro Thr Leu Tyr Gln Ile Pro Ser Leu 
305                 310                 315                 320 


Tyr Cys Ser Tyr Glu Thr Asn Ser Asn Ala Tyr Leu Leu Leu Gln Pro 
                325                 330                 335     


Ile Arg Lys Glu Val Ile His Leu Glu Pro Tyr Ile Ala Leu Tyr His 
            340                 345                 350         


Asp Phe Val Ser Asp Ser Glu Ala Gln Lys Ile Arg Glu Leu Ala Glu 
        355                 360                 365             


Pro Trp Leu Gln Arg Ser Val Val Ala Ser Gly Glu Lys Gln Leu Gln 
    370                 375                 380                 


Val Glu Tyr Arg Ile Ser Lys Ser Ala Trp Leu Lys Asp Thr Val Asp 
385                 390                 395                 400 


Pro Lys Leu Val Thr Leu Asn His Arg Ile Ala Ala Leu Thr Gly Leu 
                405                 410                 415     


Asp Val Arg Pro Pro Tyr Ala Glu Tyr Leu Gln Val Val Asn Tyr Gly 
            420                 425                 430         


Ile Gly Gly His Tyr Glu Pro His Phe Asp His Ala Thr Ser Pro Ser 
        435                 440                 445             


Ser Pro Leu Tyr Arg Met Lys Ser Gly Asn Arg Val Ala Thr Phe Met 
    450                 455                 460                 


Ile Tyr Leu Ser Ser Val Glu Ala Gly Gly Ala Thr Ala Phe Ile Tyr 
465                 470                 475                 480 


Ala Asn Leu Ser Val Pro Val Val Arg His Cys Phe Gly Gly Thr Cys 
                485                 490                 495     


Thr Gly Val Val Lys Gly Thr Val Thr His Phe Met Leu Ala Val Leu 
            500                 505                 510         


Ser Trp Trp Glu Ile Ser Gly Trp Pro Thr Ser Gly Tyr Met Ser Met 
        515                 520                 525             


Asp Arg Asn Ser Ala Asp Pro Ala Ala Pro Ala Leu Lys Thr Glu Leu 
    530                 535                 540                 


Leu Ala Glu Arg Ser Trp Trp Ser Pro Val Ala Phe Gln Arg Ser Gln 
545                 550                 555                 560 


Glu Pro Lys Ala Gly Val Gly Glu Glu Lys Ala Glu Gln Pro Pro Gly 
                565                 570                 575     


Arg Arg Pro Cys Gln Leu Cys Leu Cys Leu Ala Asn Gln Arg Gln Gly 
            580                 585                 590         


Arg Gly Cys Tyr Gln Gly Thr Leu Arg Met Tyr Ile 
        595                 600                 


<210>  9940
<211>  257
<212>  PRT
<213>  Homo Sapiens

<400>  9940

Met Gly Pro Gly Ala Arg Leu Ala Ala Leu Leu Ala Val Leu Ala Leu 
1               5                   10                  15      


Gly Thr Gly Asp Pro Glu Arg Ala Ala Ala Arg Gly Asp Thr Phe Ser 
            20                  25                  30          


Ala Leu Thr Ser Val Ala Arg Ala Leu Ala Pro Glu Arg Arg Leu Leu 
        35                  40                  45              


Gly Leu Leu Arg Arg Tyr Leu Arg Gly Glu Glu Ala Arg Leu Arg Asp 
    50                  55                  60                  


Leu Thr Arg Phe Tyr Asp Lys Val Leu Ser Leu His Glu Asp Ser Thr 
65                  70                  75                  80  


Thr Pro Val Ala Asn Pro Leu Leu Ala Phe Thr Leu Ile Lys Arg Leu 
                85                  90                  95      


Gln Ser Asp Trp Arg Asn Val Val His Ser Leu Glu Ala Ser Glu Asn 
            100                 105                 110         


Ile Arg Ala Leu Lys Asp Gly Tyr Glu Lys Val Glu Gln Asp Leu Pro 
        115                 120                 125             


Ala Phe Glu Asp Leu Glu Gly Ala Ala Arg Ala Leu Met Arg Leu Gln 
    130                 135                 140                 


Asp Val Tyr Met Leu Asn Val Lys Gly Leu Ala Arg Gly Val Phe Gln 
145                 150                 155                 160 


Arg Val Thr Gly Ser Ala Ile Thr Asp Leu Tyr Ser Pro Lys Arg Leu 
                165                 170                 175     


Phe Ser Leu Thr Gly Asp Asp Cys Phe Gln Val Gly Lys Val Ala Tyr 
            180                 185                 190         


Asp Met Gly Asp Tyr Tyr His Ala Ile Pro Trp Leu Glu Glu Ala Val 
        195                 200                 205             


Ser Leu Phe Arg Gly Ser Tyr Gly Glu Trp Lys Thr Glu Asp Glu Ala 
    210                 215                 220                 


Ser Leu Glu Asp Ala Leu Asp His Leu Ala Phe Ala Tyr Phe Arg Ala 
225                 230                 235                 240 


Gly Asn Val Ser Cys Ala Leu Ser Leu Ser Arg Glu Phe Leu Leu Tyr 
                245                 250                 255     


Arg 
    


<210>  9941
<211>  61
<212>  PRT
<213>  Homo Sapiens

<400>  9941

Ser Val Pro Val Val Arg Asn Ala Ala Leu Phe Trp Trp Asn Leu His 
1               5                   10                  15      


Arg Ser Gly Glu Gly Asp Ser Asp Thr Leu His Ala Gly Cys Pro Val 
            20                  25                  30          


Leu Val Gly Asp Lys Trp Val Ala Asn Lys Trp Ile His Glu Tyr Gly 
        35                  40                  45              


Gln Glu Phe Arg Arg Pro Cys Ser Ser Ser Pro Glu Asp 
    50                  55                  60      


<210>  9942
<211>  200
<212>  PRT
<213>  Homo Sapiens

<400>  9942

Met Glu Thr Arg Leu Pro Pro Arg Asn Ile Gln Asp Val Glu Ser Asp 
1               5                   10                  15      


Ser Ala Lys Gln Phe Leu Gln Ala Ala Glu Ala Ile Asp Asp Ile Pro 
            20                  25                  30          


Phe Gly Ile Thr Ser Asn Ser Asp Val Phe Ser Lys Tyr Gln Leu Asp 
        35                  40                  45              


Lys Asp Gly Val Val Leu Phe Lys Lys Phe Asp Glu Gly Arg Asn Asn 
    50                  55                  60                  


Phe Glu Gly Glu Val Thr Lys Glu Asn Leu Leu Asp Phe Ile Lys His 
65                  70                  75                  80  


Asn Gln Leu Pro Leu Val Ile Glu Phe Thr Glu Gln Thr Ala Pro Lys 
                85                  90                  95      


Ile Phe Gly Gly Glu Ile Lys Thr His Ile Leu Leu Phe Leu Pro Lys 
            100                 105                 110         


Ser Val Ser Asp Tyr Asp Gly Lys Leu Ser Asn Phe Lys Thr Ala Ala 
        115                 120                 125             


Glu Ser Phe Lys Gly Lys Ile Leu Phe Ile Phe Ile Asp Ser Asp His 
    130                 135                 140                 


Thr Asp Asn Gln Arg Ile Leu Glu Phe Phe Gly Leu Lys Lys Glu Glu 
145                 150                 155                 160 


Cys Pro Ala Val Arg Leu Ile Thr Leu Glu Glu Glu Met Thr Lys Tyr 
                165                 170                 175     


Lys Pro Glu Ser Glu Glu Leu Thr Ala Glu Arg Ile Thr Glu Phe Cys 
            180                 185                 190         


His Arg Phe Leu Glu Gly Lys Ile 
        195                 200 


<210>  9943
<211>  117
<212>  PRT
<213>  Homo Sapiens

<400>  9943

Met Glu Thr Arg Leu Pro Pro Arg Asn Ile Gln Phe Asp Glu Gly Arg 
1               5                   10                  15      


Asn Asn Phe Glu Gly Glu Val Thr Lys Glu Asn Leu Leu Asp Phe Ile 
            20                  25                  30          


Lys His Asn Gln Leu Pro Leu Val Ile Glu Phe Thr Glu Gln Thr Ala 
        35                  40                  45              


Pro Lys Ile Phe Gly Gly Glu Ile Lys Thr His Ile Leu Leu Phe Leu 
    50                  55                  60                  


Pro Lys Ser Val Ser Asp Tyr Asp Gly Lys Leu Ser Asn Phe Lys Thr 
65                  70                  75                  80  


Ala Ala Glu Ser Phe Lys Gly Lys Ile Leu Phe Ile Phe Ile Asp Ser 
                85                  90                  95      


Asp His Thr Asp Asn Gln Arg Ile Leu Glu Phe Phe Gly Leu Lys Lys 
            100                 105                 110         


Glu Glu Cys Pro Ala 
        115         


<210>  9944
<211>  54
<212>  PRT
<213>  Homo Sapiens

<400>  9944

Met Leu Arg Arg Ala Leu Leu Cys Leu Ala Val Ala Ala Leu Val Arg 
1               5                   10                  15      


Ala Asp Ala Pro Glu Glu Glu Asp His Val Leu Val Leu Arg Lys Ser 
            20                  25                  30          


Asn Phe Ala Glu Ala Leu Ala Ala His Lys Cys Pro Leu Val Trp Pro 
        35                  40                  45              


Leu Gln Gly Ser Gly Pro 
    50                  


<210>  9945
<211>  156
<212>  PRT
<213>  Homo Sapiens

<400>  9945

Met Leu Arg Arg Ala Leu Leu Cys Leu Ala Val Ala Ala Leu Val Arg 
1               5                   10                  15      


Ala Asp Ala Pro Glu Glu Glu Asp His Val Leu Val Leu Arg Lys Ser 
            20                  25                  30          


Asn Phe Ala Glu Ala Leu Ala Ala His Lys Tyr Leu Leu Val Asp Ala 
        35                  40                  45              


Thr Glu Glu Ser Asp Leu Ala Gln Gln Tyr Gly Val Arg Gly Tyr Pro 
    50                  55                  60                  


Thr Ile Lys Phe Phe Arg Asn Gly Asp Thr Ala Ser Pro Lys Glu Tyr 
65                  70                  75                  80  


Thr Ala Gly Arg Glu Ala Asp Asp Ile Val Asn Trp Leu Lys Lys Arg 
                85                  90                  95      


Thr Gly Pro Ala Ala Thr Thr Leu Pro Asp Gly Ala Ala Ala Glu Ser 
            100                 105                 110         


Leu Val Glu Ser Ser Glu Val Ala Val Ile Gly Phe Phe Lys Asp Val 
        115                 120                 125             


Glu Ser Asp Ser Ala Lys Gln Phe Leu Gln Ala Ala Glu Ala Ile Asp 
    130                 135                 140                 


Asp Ile Pro Phe Gly Ile Thr Ser Asn Ser Asp Val 
145                 150                 155     


<210>  9946
<211>  208
<212>  PRT
<213>  Homo Sapiens

<400>  9946

Met Leu Arg Arg Ala Leu Leu Cys Leu Ala Val Ala Ala Leu Val Arg 
1               5                   10                  15      


Ala Asp Ala Pro Glu Glu Glu Asp His Val Leu Val Leu Arg Lys Ser 
            20                  25                  30          


Asn Phe Ala Glu Ala Leu Ala Ala His Lys Tyr Leu Leu Val Glu Phe 
        35                  40                  45              


Ser Gly Arg Glu Ala Asp Asp Ile Val Asn Trp Leu Lys Lys Arg Thr 
    50                  55                  60                  


Gly Pro Ala Ala Thr Thr Leu Pro Asp Gly Ala Ala Ala Glu Ser Leu 
65                  70                  75                  80  


Val Glu Ser Ser Glu Val Ala Val Ile Gly Phe Phe Lys Asp Val Glu 
                85                  90                  95      


Ser Asp Ser Ala Lys Gln Phe Leu Gln Ala Ala Glu Ala Ile Asp Asp 
            100                 105                 110         


Ile Pro Phe Gly Ile Thr Ser Asn Ser Asp Val Phe Ser Lys Tyr Gln 
        115                 120                 125             


Leu Asp Lys Asp Gly Val Val Leu Phe Lys Lys Phe Asp Glu Gly Arg 
    130                 135                 140                 


Asn Asn Phe Glu Gly Glu Val Thr Lys Glu Asn Leu Leu Asp Phe Ile 
145                 150                 155                 160 


Lys His Asn Gln Leu Pro Leu Val Ile Glu Phe Thr Glu Gln Thr Ala 
                165                 170                 175     


Pro Lys Ile Phe Gly Gly Glu Ile Lys Thr His Ile Leu Leu Phe Leu 
            180                 185                 190         


Pro Lys Ser Val Ser Asp Tyr Asp Gly Lys Leu Ser Asn Phe Lys Thr 
        195                 200                 205             


<210>  9947
<211>  148
<212>  PRT
<213>  Homo Sapiens

<400>  9947

Met Leu Arg Arg Ala Leu Leu Cys Leu Ala Val Ala Ala Leu Val Arg 
1               5                   10                  15      


Ala Asp Ala Pro Glu Glu Glu Asp His Val Leu Val Leu Arg Lys Ser 
            20                  25                  30          


Asn Phe Ala Glu Ala Leu Ala Ala His Lys Tyr Leu Leu Val Glu Phe 
        35                  40                  45              


Tyr Ala Pro Trp Cys Gly His Cys Lys Ala Leu Ala Pro Glu Tyr Ala 
    50                  55                  60                  


Lys Ala Ala Gly Lys Leu Lys Ala Glu Gly Ser Glu Ile Arg Leu Ala 
65                  70                  75                  80  


Lys Met Asp Ser Thr Ala Asn Glu Val Glu Ala Val Lys Val His Ser 
                85                  90                  95      


Phe Pro Thr Leu Lys Phe Phe Pro Ala Ser Ala Asp Arg Thr Val Ile 
            100                 105                 110         


Asp Tyr Asn Gly Glu Arg Thr Leu Asp Gly Phe Lys Lys Phe Leu Glu 
        115                 120                 125             


Ser Gly Gly Gln Asp Gly Ala Gly Asp Asp Asp Asp Leu Glu Asp Leu 
    130                 135                 140                 


Glu Glu Ala Glu 
145             


<210>  9948
<211>  188
<212>  PRT
<213>  Homo Sapiens

<400>  9948

Met Leu Arg Arg Ala Leu Leu Cys Leu Ala Val Ala Ala Leu Val Arg 
1               5                   10                  15      


Ala Asp Ala Pro Glu Glu Glu Asp His Val Leu Val Leu Arg Lys Ser 
            20                  25                  30          


Asn Phe Ala Glu Ala Leu Ala Ala His Lys Tyr Leu Leu Val Glu Phe 
        35                  40                  45              


Tyr Ala Pro Trp Cys Gly His Cys Lys Ala Leu Ala Pro Glu Tyr Ala 
    50                  55                  60                  


Lys Ala Ala Gly Lys Leu Lys Ala Glu Gly Ser Glu Ile Arg Leu Ala 
65                  70                  75                  80  


Lys Val Asp Ala Thr Glu Glu Ser Asp Leu Ala Gln Gln Tyr Gly Val 
                85                  90                  95      


Arg Gly Tyr Pro Thr Ile Lys Phe Phe Arg Asn Gly Asp Thr Ala Ser 
            100                 105                 110         


Pro Lys Glu Tyr Thr Ala Ala Glu Ser Leu Val Glu Ser Ser Glu Val 
        115                 120                 125             


Ala Val Ile Gly Phe Phe Lys Asp Val Glu Ser Asp Ser Ala Lys Gln 
    130                 135                 140                 


Phe Leu Gln Ala Ala Glu Ala Ile Asp Asp Ile Pro Phe Gly Ile Thr 
145                 150                 155                 160 


Ser Asn Ser Asp Val Phe Ser Lys Tyr Gln Leu Asp Lys Asp Gly Val 
                165                 170                 175     


Val Leu Phe Lys Lys Phe Asp Glu Gly Arg Asn Asn 
            180                 185             


<210>  9949
<211>  508
<212>  PRT
<213>  Homo Sapiens

<400>  9949

Met Leu Arg Arg Ala Leu Leu Cys Leu Ala Val Ala Ala Leu Val Arg 
1               5                   10                  15      


Ala Asp Ala Pro Glu Glu Glu Asp His Val Leu Val Leu Arg Lys Ser 
            20                  25                  30          


Asn Phe Ala Glu Ala Leu Ala Ala His Lys Tyr Leu Leu Val Glu Phe 
        35                  40                  45              


Tyr Ala Pro Trp Cys Gly His Cys Lys Ala Leu Ala Pro Glu Tyr Ala 
    50                  55                  60                  


Lys Ala Ala Gly Lys Leu Lys Ala Glu Gly Ser Glu Ile Arg Leu Ala 
65                  70                  75                  80  


Lys Val Asp Ala Thr Glu Glu Ser Asp Leu Ala Gln Gln Tyr Gly Val 
                85                  90                  95      


Arg Gly Tyr Pro Thr Ile Lys Phe Phe Arg Asn Gly Asp Thr Ala Ser 
            100                 105                 110         


Pro Lys Glu Tyr Thr Ala Gly Arg Glu Ala Asp Asp Ile Val Asn Trp 
        115                 120                 125             


Leu Lys Lys Arg Thr Gly Pro Ala Ala Thr Thr Leu Pro Asp Gly Ala 
    130                 135                 140                 


Ala Ala Glu Ser Leu Val Glu Ser Ser Glu Val Ala Val Ile Gly Phe 
145                 150                 155                 160 


Phe Lys Asp Val Glu Ser Asp Ser Ala Lys Gln Phe Leu Gln Ala Ala 
                165                 170                 175     


Glu Ala Ile Asp Asp Ile Pro Phe Gly Ile Thr Ser Asn Ser Asp Val 
            180                 185                 190         


Phe Ser Lys Tyr Gln Leu Asp Lys Asp Gly Val Val Leu Phe Lys Lys 
        195                 200                 205             


Phe Asp Glu Gly Arg Asn Asn Phe Glu Gly Glu Val Thr Lys Glu Asn 
    210                 215                 220                 


Leu Leu Asp Phe Ile Lys His Asn Gln Leu Pro Leu Val Ile Glu Phe 
225                 230                 235                 240 


Thr Glu Gln Thr Ala Pro Lys Ile Phe Gly Gly Glu Ile Lys Thr His 
                245                 250                 255     


Ile Leu Leu Phe Leu Pro Lys Ser Val Ser Asp Tyr Asp Gly Lys Leu 
            260                 265                 270         


Ser Asn Phe Lys Thr Ala Ala Glu Ser Phe Lys Gly Lys Ile Leu Phe 
        275                 280                 285             


Ile Phe Ile Asp Ser Asp His Thr Asp Asn Gln Arg Ile Leu Glu Phe 
    290                 295                 300                 


Phe Gly Leu Lys Lys Glu Glu Cys Pro Ala Val Arg Leu Ile Thr Leu 
305                 310                 315                 320 


Glu Glu Glu Met Thr Lys Tyr Lys Pro Glu Ser Glu Glu Leu Thr Ala 
                325                 330                 335     


Glu Arg Ile Thr Glu Phe Cys His Arg Phe Leu Glu Gly Lys Ile Lys 
            340                 345                 350         


Pro His Leu Met Ser Gln Glu Leu Pro Glu Asp Trp Asp Lys Gln Pro 
        355                 360                 365             


Val Lys Val Leu Val Gly Lys Asn Phe Glu Asp Val Ala Phe Asp Glu 
    370                 375                 380                 


Lys Lys Asn Val Phe Val Glu Phe Tyr Ala Pro Trp Cys Gly His Cys 
385                 390                 395                 400 


Lys Gln Leu Ala Pro Ile Trp Asp Lys Leu Gly Glu Thr Tyr Lys Asp 
                405                 410                 415     


His Glu Asn Ile Val Ile Ala Lys Met Asp Ser Thr Ala Asn Glu Val 
            420                 425                 430         


Glu Ala Val Lys Val His Ser Phe Pro Thr Leu Lys Phe Phe Pro Ala 
        435                 440                 445             


Ser Ala Asp Arg Thr Val Ile Asp Tyr Asn Gly Glu Arg Thr Leu Asp 
    450                 455                 460                 


Gly Phe Lys Lys Phe Leu Glu Ser Gly Gly Gln Asp Gly Ala Gly Asp 
465                 470                 475                 480 


Asp Asp Asp Leu Glu Asp Leu Glu Glu Ala Glu Glu Pro Asp Met Glu 
                485                 490                 495     


Glu Asp Asp Asp Gln Lys Ala Val Lys Asp Glu Leu 
            500                 505             


<210>  9950
<211>  464
<212>  PRT
<213>  Homo Sapiens

<400>  9950

Met Leu Arg Arg Ala Leu Leu Cys Leu Ala Val Ala Ala Leu Val Arg 
1               5                   10                  15      


Ala Asp Ala Pro Glu Glu Glu Asp His Val Leu Val Leu Arg Lys Ser 
            20                  25                  30          


Asn Phe Ala Glu Ala Leu Ala Ala His Lys Tyr Leu Leu Val Glu Phe 
        35                  40                  45              


Tyr Ala Pro Trp Cys Gly His Cys Lys Ala Leu Ala Pro Glu Tyr Ala 
    50                  55                  60                  


Lys Ala Ala Gly Lys Leu Lys Ala Glu Gly Ser Glu Ile Arg Leu Ala 
65                  70                  75                  80  


Lys Val Asp Ala Thr Glu Glu Ser Asp Leu Ala Gln Gln Tyr Gly Val 
                85                  90                  95      


Arg Gly Tyr Pro Thr Ile Lys Phe Phe Arg Asn Gly Asp Thr Ala Ser 
            100                 105                 110         


Pro Lys Glu Tyr Thr Gly Asp Val Glu Ser Asp Ser Ala Lys Gln Phe 
        115                 120                 125             


Leu Gln Ala Ala Glu Ala Ile Asp Asp Ile Pro Phe Gly Ile Thr Ser 
    130                 135                 140                 


Asn Ser Asp Val Phe Ser Lys Tyr Gln Leu Asp Lys Asp Gly Val Val 
145                 150                 155                 160 


Leu Phe Lys Lys Phe Asp Glu Gly Arg Asn Asn Phe Glu Gly Glu Val 
                165                 170                 175     


Thr Lys Glu Asn Leu Leu Asp Phe Ile Lys His Asn Gln Leu Pro Leu 
            180                 185                 190         


Val Ile Glu Phe Thr Glu Gln Thr Ala Pro Lys Ile Phe Gly Gly Glu 
        195                 200                 205             


Ile Lys Thr His Ile Leu Leu Phe Leu Pro Lys Ser Val Ser Asp Tyr 
    210                 215                 220                 


Asp Gly Lys Leu Ser Asn Phe Lys Thr Ala Ala Glu Ser Phe Lys Gly 
225                 230                 235                 240 


Lys Ile Leu Phe Ile Phe Ile Asp Ser Asp His Thr Asp Asn Gln Arg 
                245                 250                 255     


Ile Leu Glu Phe Phe Gly Leu Lys Lys Glu Glu Cys Pro Ala Val Arg 
            260                 265                 270         


Leu Ile Thr Leu Glu Glu Glu Met Thr Lys Tyr Lys Pro Glu Ser Glu 
        275                 280                 285             


Glu Leu Thr Ala Glu Arg Ile Thr Glu Phe Cys His Arg Phe Leu Glu 
    290                 295                 300                 


Gly Lys Ile Lys Pro His Leu Met Ser Gln Glu Leu Pro Glu Asp Trp 
305                 310                 315                 320 


Asp Lys Gln Pro Val Lys Val Leu Val Gly Lys Asn Phe Glu Asp Val 
                325                 330                 335     


Ala Phe Asp Glu Lys Lys Asn Val Phe Val Glu Phe Tyr Ala Pro Trp 
            340                 345                 350         


Cys Gly His Cys Lys Gln Leu Ala Pro Ile Trp Asp Lys Leu Gly Glu 
        355                 360                 365             


Thr Tyr Lys Asp His Glu Asn Ile Val Ile Ala Lys Met Asp Ser Thr 
    370                 375                 380                 


Ala Asn Glu Val Glu Ala Val Lys Val His Ser Phe Pro Thr Leu Lys 
385                 390                 395                 400 


Phe Phe Pro Ala Ser Ala Asp Arg Thr Val Ile Asp Tyr Asn Gly Glu 
                405                 410                 415     


Arg Thr Leu Asp Gly Phe Lys Lys Phe Leu Glu Ser Gly Gly Gln Asp 
            420                 425                 430         


Gly Ala Gly Asp Asp Asp Asp Leu Glu Asp Leu Glu Glu Ala Glu Glu 
        435                 440                 445             


Pro Asp Met Glu Glu Asp Asp Asp Gln Lys Ala Val Lys Asp Glu Leu 
    450                 455                 460                 


<210>  9951
<211>  166
<212>  PRT
<213>  Homo Sapiens

<400>  9951

Met Leu Arg Arg Ala Leu Leu Cys Leu Ala Val Ala Ala Leu Val Arg 
1               5                   10                  15      


Ala Asp Ala Pro Glu Glu Glu Asp His Val Leu Val Leu Arg Lys Ser 
            20                  25                  30          


Asn Phe Ala Glu Ala Leu Ala Ala His Lys Tyr Leu Leu Val Glu Phe 
        35                  40                  45              


Tyr Ala Pro Trp Cys Gly His Cys Lys Ala Leu Ala Pro Glu Tyr Ala 
    50                  55                  60                  


Lys Ala Ala Gly Lys Leu Lys Ala Glu Gly Ser Glu Ile Arg Leu Ala 
65                  70                  75                  80  


Lys Val Asp Ala Thr Glu Glu Ser Asp Leu Ala Gln Gln Tyr Gly Val 
                85                  90                  95      


Arg Gly Tyr Pro Thr Ile Lys Phe Phe Arg Asn Gly Asp Thr Ala Ser 
            100                 105                 110         


Pro Lys Glu Tyr Thr Gly Phe Asp Glu Gly Arg Asn Asn Phe Glu Gly 
        115                 120                 125             


Glu Val Thr Lys Glu Asn Leu Leu Asp Phe Ile Lys His Asn Gln Leu 
    130                 135                 140                 


Pro Leu Val Ile Glu Phe Thr Glu Gln Thr Ala Pro Lys Ile Phe Gly 
145                 150                 155                 160 


Gly Glu Ile Lys Thr His 
                165     


<210>  9952
<211>  106
<212>  PRT
<213>  Homo Sapiens

<400>  9952

Met Leu Arg Arg Ala Leu Leu Cys Leu Ala Val Ala Ala Leu Val Arg 
1               5                   10                  15      


Ala Asp Ala Pro Glu Glu Glu Asp His Val Leu Val Leu Arg Lys Ser 
            20                  25                  30          


Asn Phe Ala Glu Ala Leu Ala Ala His Lys Tyr Leu Leu Val Glu Phe 
        35                  40                  45              


Tyr Ala Pro Trp Cys Gly His Cys Lys Ala Leu Ala Pro Glu Tyr Ala 
    50                  55                  60                  


Lys Ala Ala Gly Lys Leu Lys Ala Glu Gly Ser Glu Ile Arg Pro Pro 
65                  70                  75                  80  


Arg Arg Ser Leu Ser Pro Val Trp Glu Gly Arg Ser Arg Thr Gly His 
                85                  90                  95      


Gly His Ser Val Pro Pro Ala Val Ser Pro 
            100                 105     


<210>  9953
<211>  274
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9953

Xaa Phe Glu Gly Glu Val Thr Lys Glu Asn Leu Leu Asp Phe Ile Lys 
1               5                   10                  15      


His Asn Gln Leu Pro Leu Val Ile Glu Phe Thr Glu Gln Ser Val Ser 
            20                  25                  30          


Asp Tyr Asp Gly Lys Leu Ser Asn Phe Lys Thr Ala Ala Glu Ser Phe 
        35                  40                  45              


Lys Gly Lys Ile Leu Phe Ile Phe Ile Asp Ser Asp His Thr Asp Asn 
    50                  55                  60                  


Gln Arg Ile Leu Glu Phe Phe Gly Leu Lys Lys Glu Glu Cys Pro Ala 
65                  70                  75                  80  


Val Arg Leu Ile Thr Leu Glu Glu Glu Met Thr Lys Tyr Lys Pro Glu 
                85                  90                  95      


Ser Glu Glu Leu Thr Ala Glu Arg Ile Thr Glu Phe Cys His Arg Phe 
            100                 105                 110         


Leu Glu Gly Lys Ile Lys Pro His Leu Met Ser Gln Glu Leu Pro Glu 
        115                 120                 125             


Asp Trp Asp Lys Gln Pro Val Lys Val Leu Val Gly Lys Asn Phe Glu 
    130                 135                 140                 


Asp Val Ala Phe Asp Glu Lys Lys Asn Val Phe Val Glu Phe Tyr Ala 
145                 150                 155                 160 


Pro Trp Cys Gly His Cys Lys Gln Leu Ala Pro Ile Trp Asp Lys Leu 
                165                 170                 175     


Gly Glu Thr Tyr Lys Asp His Glu Asn Ile Val Ile Ala Lys Met Asp 
            180                 185                 190         


Ser Thr Ala Asn Glu Val Glu Ala Val Lys Val His Ser Phe Pro Thr 
        195                 200                 205             


Leu Lys Phe Phe Pro Ala Ser Ala Asp Arg Thr Val Ile Asp Tyr Asn 
    210                 215                 220                 


Gly Glu Arg Thr Leu Asp Gly Phe Lys Lys Phe Leu Glu Ser Gly Gly 
225                 230                 235                 240 


Gln Asp Gly Ala Gly Asp Asp Asp Asp Leu Glu Asp Leu Glu Glu Ala 
                245                 250                 255     


Glu Glu Pro Asp Met Glu Glu Asp Asp Asp Gln Lys Ala Val Lys Asp 
            260                 265                 270         


Glu Leu 
        


<210>  9954
<211>  132
<212>  PRT
<213>  Homo Sapiens

<400>  9954

Leu Met Ala Thr Leu Lys Ala Pro Leu Arg Val His Ile Thr Ser Leu 
1               5                   10                  15      


Leu Pro Thr Pro Glu Asp Asn Leu Glu Ile Val Leu His Arg Trp Glu 
            20                  25                  30          


Asn Asn Ser Cys Val Glu Lys Lys Val Leu Gly Glu Lys Thr Glu Asn 
        35                  40                  45              


Pro Lys Lys Phe Lys Ile Asn Tyr Thr Val Ala Asn Glu Ala Thr Leu 
    50                  55                  60                  


Leu Asp Thr Asp Tyr Asp Asn Phe Leu Phe Leu Cys Leu Gln Asp Thr 
65                  70                  75                  80  


Thr Thr Pro Ile Gln Ser Met Met Cys Gln Tyr Leu Ala Arg Val Leu 
                85                  90                  95      


Val Glu Asp Asp Glu Ile Met Gln Gly Phe Ile Arg Ala Phe Arg Pro 
            100                 105                 110         


Leu Pro Arg His Leu Trp Tyr Leu Leu Asp Leu Lys Gln Met Glu Glu 
        115                 120                 125             


Pro Cys Arg Phe 
    130         


<210>  9955
<211>  143
<212>  PRT
<213>  Homo Sapiens

<400>  9955

Met Leu Cys Leu Leu Leu Thr Leu Gly Val Ala Leu Val Cys Gly Val 
1               5                   10                  15      


Pro Ala Met Asp Ile Pro Gln Thr Lys Gln Asp Leu Glu Leu Pro Lys 
            20                  25                  30          


Leu Ala Gly Thr Trp His Ser Met Ala Met Ala Thr Asn Asn Ile Ser 
        35                  40                  45              


Leu Met Ala Thr Leu Lys Ala Pro Leu Arg Val His Ile Thr Ser Leu 
    50                  55                  60                  


Leu Pro Thr Pro Glu Asp Asn Leu Glu Ile Val Leu His Arg Trp Glu 
65                  70                  75                  80  


Asn Asn Ser Cys Val Glu Lys Lys Val Leu Gly Glu Lys Thr Glu Asn 
                85                  90                  95      


Pro Lys Lys Phe Lys Ile Asn Ser Arg Val Leu Val Glu Asp Asp Glu 
            100                 105                 110         


Ile Met Gln Gly Phe Ile Arg Ala Phe Arg Pro Leu Pro Arg His Leu 
        115                 120                 125             


Trp Tyr Leu Leu Asp Leu Lys Gln Met Glu Glu Pro Cys Arg Phe 
    130                 135                 140             


<210>  9956
<211>  180
<212>  PRT
<213>  Homo Sapiens

<400>  9956

Met Leu Cys Leu Leu Leu Thr Leu Gly Val Ala Leu Val Cys Gly Val 
1               5                   10                  15      


Pro Ala Met Asp Ile Pro Gln Thr Lys Gln Asp Leu Glu Leu Pro Lys 
            20                  25                  30          


Leu Ala Gly Thr Trp His Ser Met Ala Met Ala Thr Asn Asn Ile Ser 
        35                  40                  45              


Leu Met Ala Thr Leu Lys Ala Pro Leu Arg Val His Ile Thr Ser Leu 
    50                  55                  60                  


Leu Pro Thr Pro Glu Asp Asn Leu Glu Ile Val Leu His Arg Trp Glu 
65                  70                  75                  80  


Asn Asn Ser Cys Val Glu Lys Lys Val Leu Gly Glu Lys Thr Glu Asn 
                85                  90                  95      


Pro Lys Lys Phe Lys Ile Asn Tyr Thr Val Ala Asn Glu Ala Thr Leu 
            100                 105                 110         


Leu Asp Thr Asp Tyr Asp Asn Phe Leu Phe Leu Cys Leu Gln Asp Thr 
        115                 120                 125             


Thr Thr Pro Ile Gln Ser Met Met Cys Gln Tyr Leu Ala Arg Val Leu 
    130                 135                 140                 


Val Glu Asp Asp Glu Ile Met Gln Gly Phe Ile Arg Ala Phe Arg Pro 
145                 150                 155                 160 


Leu Pro Arg His Leu Trp Tyr Leu Leu Asp Leu Lys Gln Met Glu Glu 
                165                 170                 175     


Pro Cys Arg Phe 
            180 


<210>  9957
<211>  180
<212>  PRT
<213>  Homo Sapiens

<400>  9957

Met Leu Cys Leu Leu Leu Thr Leu Gly Val Ala Leu Val Cys Gly Val 
1               5                   10                  15      


Pro Ala Met Asp Ile Pro Gln Thr Lys Gln Asp Leu Glu Leu Pro Lys 
            20                  25                  30          


Leu Ala Gly Thr Trp His Ser Met Ala Met Ala Thr Asn Asn Ile Ser 
        35                  40                  45              


Leu Met Ala Thr Leu Lys Ala Pro Leu Arg Val His Ile Thr Ser Leu 
    50                  55                  60                  


Leu Pro Thr Pro Glu Asp Asn Leu Glu Ile Val Leu His Arg Trp Glu 
65                  70                  75                  80  


Asn Asn Ser Cys Val Glu Lys Lys Val Leu Gly Glu Lys Thr Glu Asn 
                85                  90                  95      


Pro Lys Lys Phe Lys Ile Asn Tyr Thr Val Ala Asn Glu Ala Thr Leu 
            100                 105                 110         


Leu Asp Thr Asp Tyr Asp Asn Phe Leu Phe Leu Cys Leu Gln Asp Thr 
        115                 120                 125             


Thr Thr Pro Ile Gln Ser Met Met Cys Gln Tyr Leu Ala Arg Val Leu 
    130                 135                 140                 


Val Glu Asp Asp Glu Ile Met Gln Gly Phe Ile Arg Ala Phe Arg Pro 
145                 150                 155                 160 


Leu Pro Arg His Leu Trp Tyr Leu Leu Asp Leu Lys Gln Met Glu Glu 
                165                 170                 175     


Pro Cys Arg Phe 
            180 


<210>  9958
<211>  180
<212>  PRT
<213>  Homo Sapiens

<400>  9958

Met Leu Cys Leu Leu Leu Thr Leu Gly Val Ala Leu Val Cys Gly Val 
1               5                   10                  15      


Pro Ala Met Asp Ile Pro Gln Thr Lys Gln Asp Leu Glu Leu Pro Lys 
            20                  25                  30          


Leu Ala Gly Thr Trp His Ser Met Ala Met Ala Thr Asn Asn Ile Ser 
        35                  40                  45              


Leu Met Ala Thr Leu Lys Ala Pro Leu Arg Val His Ile Thr Ser Leu 
    50                  55                  60                  


Leu Pro Thr Pro Glu Asp Asn Leu Glu Ile Val Leu His Arg Trp Glu 
65                  70                  75                  80  


Asn Asn Ser Cys Val Glu Lys Lys Val Leu Gly Glu Lys Thr Glu Asn 
                85                  90                  95      


Pro Lys Lys Phe Lys Ile Asn Tyr Thr Val Ala Asn Glu Ala Thr Leu 
            100                 105                 110         


Leu Asp Thr Asp Tyr Asp Asn Phe Leu Phe Leu Cys Leu Gln Asp Thr 
        115                 120                 125             


Thr Thr Pro Ile Gln Ser Met Met Cys Gln Tyr Leu Ala Arg Val Leu 
    130                 135                 140                 


Val Glu Asp Asp Glu Ile Met Gln Gly Phe Ile Arg Ala Phe Arg Pro 
145                 150                 155                 160 


Leu Pro Arg His Leu Trp Tyr Leu Leu Asp Leu Lys Gln Met Glu Glu 
                165                 170                 175     


Pro Cys Arg Phe 
            180 


<210>  9959
<211>  169
<212>  PRT
<213>  Homo Sapiens

<400>  9959

Met Leu Cys Leu Leu Leu Thr Leu Gly Val Ala Leu Val Cys Gly Val 
1               5                   10                  15      


Pro Ala Met Asp Ile Pro Gln Thr Lys Gln Asp Leu Glu Leu Pro Lys 
            20                  25                  30          


Leu Ala Gly Thr Trp His Ser Met Ala Met Ala Thr Asn Asn Ile Ser 
        35                  40                  45              


Leu Met Ala Thr Leu Lys Ala Pro Leu Arg Val His Ile Thr Ser Leu 
    50                  55                  60                  


Leu Pro Thr Pro Glu Asp Asn Leu Glu Ile Val Leu His Arg Trp Glu 
65                  70                  75                  80  


Asn Asn Ser Cys Val Glu Lys Lys Val Leu Gly Glu Lys Thr Glu Asn 
                85                  90                  95      


Pro Lys Lys Phe Lys Ile Asn Tyr Thr Val Ala Asn Glu Ala Thr Leu 
            100                 105                 110         


Leu Asp Thr Asp Tyr Asp Asn Phe Leu Phe Leu Cys Leu Gln Asp Thr 
        115                 120                 125             


Thr Thr Pro Ile Gln Ser Met Met Cys Gln Tyr Leu Glu Ser Trp Trp 
    130                 135                 140                 


Arg Thr Met Arg Ser Cys Arg Asp Ser Ser Gly Leu Ser Gly Pro Cys 
145                 150                 155                 160 


Pro Gly Thr Tyr Gly Thr Cys Trp Thr 
                165                 


<210>  9960
<211>  33
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9960

Xaa Glu Ile Met Gln Gly Phe Ile Arg Ala Phe Arg Pro Leu Pro Arg 
1               5                   10                  15      


His Leu Trp Tyr Leu Leu Asp Leu Lys Gln Met Glu Glu Pro Cys Arg 
            20                  25                  30          


Phe 
    


<210>  9961
<211>  126
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9961

Xaa Pro Leu Arg Val His Ile Thr Ser Leu Leu Pro Thr Pro Glu Asp 
1               5                   10                  15      


Asn Leu Glu Ile Val Leu His Arg Trp Glu Asn Asn Ser Cys Val Glu 
            20                  25                  30          


Lys Lys Val Leu Gly Glu Lys Thr Glu Asn Pro Lys Lys Phe Lys Ile 
        35                  40                  45              


Asn Tyr Thr Val Ala Asn Glu Ala Thr Leu Leu Asp Thr Asp Tyr Asp 
    50                  55                  60                  


Asn Phe Leu Phe Leu Cys Leu Gln Asp Thr Thr Thr Pro Ile Gln Ser 
65                  70                  75                  80  


Met Met Cys Gln Tyr Leu Ala Arg Val Leu Val Glu Asp Asp Glu Ile 
                85                  90                  95      


Met Gln Gly Phe Ile Arg Ala Phe Arg Pro Leu Pro Arg His Leu Trp 
            100                 105                 110         


Tyr Leu Leu Asp Leu Lys Gln Met Glu Glu Pro Cys Arg Phe 
        115                 120                 125     


<210>  9962
<211>  131
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9962

Xaa Val Pro Ala Met Asp Ile Pro Gln Thr Lys Gln Asp Leu Glu Leu 
1               5                   10                  15      


Pro Lys Ala Pro Leu Arg Val His Ile Thr Ser Leu Leu Pro Thr Pro 
            20                  25                  30          


Glu Asp Asn Leu Glu Ile Val Leu His Arg Trp Glu Asn Asn Ser Cys 
        35                  40                  45              


Val Glu Lys Lys Val Leu Gly Glu Lys Thr Glu Asn Pro Lys Lys Phe 
    50                  55                  60                  


Lys Ile Asn Cys Lys Ala Ser Gly Ala Pro Gln Leu Ser Trp Lys Pro 
65                  70                  75                  80  


Gln Gly Pro Arg Thr Asp Pro Ala Ser Ser Thr Ala Arg Val Leu Val 
                85                  90                  95      


Glu Asp Asp Glu Ile Met Gln Gly Phe Ile Arg Ala Phe Arg Pro Leu 
            100                 105                 110         


Pro Arg His Leu Trp Tyr Leu Leu Asp Leu Lys Gln Met Glu Glu Pro 
        115                 120                 125             


Cys Arg Phe 
    130     


<210>  9963
<211>  25
<212>  PRT
<213>  Homo Sapiens

<400>  9963

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
1               5                   10                  15      


Ser Cys Leu Ala Phe Arg Ser Pro Leu 
            20                  25  


<210>  9964
<211>  28
<212>  PRT
<213>  Homo Sapiens

<400>  9964

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
1               5                   10                  15      


Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe 
            20                  25              


<210>  9965
<211>  29
<212>  PRT
<213>  Homo Sapiens

<400>  9965

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
1               5                   10                  15      


Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe Lys 
            20                  25                  


<210>  9966
<211>  42
<212>  PRT
<213>  Homo Sapiens

<400>  9966

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
1               5                   10                  15      


Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe Lys Arg Phe Lys 
            20                  25                  30          


Glu Thr Thr Arg Pro Phe Ser Asn Glu Cys 
        35                  40          


<210>  9967
<211>  53
<212>  PRT
<213>  Homo Sapiens

<400>  9967

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
1               5                   10                  15      


Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe Lys Arg Phe Lys 
            20                  25                  30          


Glu Thr Thr Arg Pro Phe Ser Asn Glu Cys Leu Gly Thr Thr Arg Pro 
        35                  40                  45              


Val Val Pro Ile Asp 
    50              


<210>  9968
<211>  68
<212>  PRT
<213>  Homo Sapiens

<400>  9968

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
1               5                   10                  15      


Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe Lys Arg Phe Lys 
            20                  25                  30          


Glu Thr Thr Arg Pro Phe Ser Asn Glu Cys Leu Gly Thr Thr Arg Pro 
        35                  40                  45              


Val Val Pro Ile Asp Ser Ser Asp Phe Ala Leu Asp Ile Arg Met Pro 
    50                  55                  60                  


Gly Val Thr Pro 
65              


<210>  9969
<211>  175
<212>  PRT
<213>  Homo Sapiens

<400>  9969

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
1               5                   10                  15      


Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe Lys Arg Phe Lys 
            20                  25                  30          


Glu Thr Thr Arg Pro Phe Ser Asn Glu Cys Leu Gly Thr Thr Arg Pro 
        35                  40                  45              


Val Val Pro Ile Asp Ser Ser Asp Phe Ala Leu Asp Ile Arg Met Pro 
    50                  55                  60                  


Gly Val Thr Pro Lys Gln Leu Thr Ser Ser Leu Glu Pro Ala Trp Ile 
65                  70                  75                  80  


Leu Ser Ile Thr Cys Tyr Phe Leu Asp Ala Ile Cys Leu His Pro Leu 
                85                  90                  95      


Glu Val Thr Gly Phe Val Met Lys Glu Pro Val Gln Ile Lys Pro Ile 
            100                 105                 110         


Phe Cys Met Pro Gly Arg Glu Met Leu Pro Leu Pro Gly Ser Pro Lys 
        115                 120                 125             


Val Leu Asp Ser Glu Leu Glu Glu Arg Leu Glu Val Asn Thr Leu Tyr 
    130                 135                 140                 


Tyr Arg Tyr Thr Met Gly Ile Leu Val Leu Leu Glu Ile Ile Thr Arg 
145                 150                 155                 160 


Thr Val Leu Val Cys Pro Tyr Thr Ser His Val Cys His Ser Leu 
                165                 170                 175 


<210>  9970
<211>  974
<212>  PRT
<213>  Homo Sapiens

<400>  9970

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
1               5                   10                  15      


Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe Lys Arg Phe Lys 
            20                  25                  30          


Glu Thr Thr Arg Pro Phe Ser Asn Glu Cys Leu Gly Thr Thr Arg Pro 
        35                  40                  45              


Val Val Pro Ile Asp Ser Ser Asp Phe Ala Leu Asp Ile Arg Met Pro 
    50                  55                  60                  


Gly Val Thr Pro Lys Gln Ser Asp Thr Tyr Phe Cys Met Ser Met Arg 
65                  70                  75                  80  


Ile Pro Val Asp Glu Glu Ala Phe Val Ile Asp Phe Lys Pro Arg Ala 
                85                  90                  95      


Ser Met Asp Thr Val His His Met Leu Leu Phe Gly Cys Asn Met Pro 
            100                 105                 110         


Ser Ser Thr Gly Ser Tyr Trp Phe Cys Asp Glu Gly Thr Cys Thr Asp 
        115                 120                 125             


Lys Ala Asn Ile Leu Tyr Ala Trp Ala Arg Asn Ala Pro Pro Thr Arg 
    130                 135                 140                 


Leu Pro Lys Gly Val Gly Phe Arg Val Gly Gly Glu Thr Gly Ser Lys 
145                 150                 155                 160 


Tyr Phe Val Leu Gln Val His Tyr Gly Asp Ile Ser Ala Phe Arg Asp 
                165                 170                 175     


Asn Asn Lys Asp Cys Ser Gly Val Ser Leu His Leu Thr Arg Leu Pro 
            180                 185                 190         


Gln Pro Leu Ile Ala Gly Met Tyr Leu Met Met Ser Val Asp Thr Val 
        195                 200                 205             


Ile Pro Ala Gly Glu Lys Val Val Asn Ser Asp Ile Ser Cys His Tyr 
    210                 215                 220                 


Lys Asn Tyr Pro Met His Val Phe Ala Tyr Arg Val His Thr His His 
225                 230                 235                 240 


Leu Gly Lys Val Val Ser Gly Tyr Arg Val Arg Asn Gly Gln Trp Thr 
                245                 250                 255     


Leu Ile Gly Arg Gln Ser Pro Gln Leu Pro Gln Ala Phe Tyr Pro Val 
            260                 265                 270         


Gly His Pro Val Asp Val Ser Phe Gly Asp Leu Leu Ala Ala Arg Cys 
        275                 280                 285             


Val Phe Thr Gly Glu Gly Arg Thr Glu Ala Thr His Ile Gly Gly Thr 
    290                 295                 300                 


Ser Ser Asp Glu Met Cys Asn Leu Tyr Ile Met Tyr Tyr Met Glu Ala 
305                 310                 315                 320 


Lys His Ala Val Ser Phe Met Thr Cys Thr Gln Asn Val Ala Pro Asp 
                325                 330                 335     


Met Phe Arg Thr Ile Pro Pro Glu Ala Asn Ile Pro Ile Pro Val Lys 
            340                 345                 350         


Ser Asp Met Val Met Met His Glu His His Lys Glu Thr Glu Tyr Lys 
        355                 360                 365             


Asp Lys Ile Pro Leu Leu Gln Gln Pro Lys Arg Glu Glu Glu Glu Val 
    370                 375                 380                 


Leu Asp Gln Gly Asp Phe Tyr Ser Leu Leu Ser Lys Leu Leu Gly Glu 
385                 390                 395                 400 


Arg Glu Asp Val Val His Val His Lys Tyr Asn Pro Thr Glu Lys Ala 
                405                 410                 415     


Glu Ser Glu Ser Asp Leu Val Ala Glu Ile Ala Asn Val Val Gln Lys 
            420                 425                 430         


Lys Asp Leu Gly Arg Ser Asp Ala Arg Glu Gly Ala Glu His Glu Arg 
        435                 440                 445             


Gly Asn Ala Ile Leu Val Arg Asp Arg Ile His Lys Phe His Arg Leu 
    450                 455                 460                 


Val Ser Thr Leu Arg Pro Pro Glu Ser Arg Val Phe Ser Leu Gln Gln 
465                 470                 475                 480 


Pro Pro Pro Gly Glu Gly Thr Trp Glu Pro Glu His Thr Gly Asp Phe 
                485                 490                 495     


His Met Glu Glu Ala Leu Asp Trp Pro Gly Val Tyr Leu Leu Pro Gly 
            500                 505                 510         


Gln Val Ser Gly Val Ala Leu Asp Pro Lys Asn Asn Leu Val Ile Phe 
        515                 520                 525             


His Arg Gly Asp His Val Trp Asp Gly Asn Ser Phe Asp Ser Lys Phe 
    530                 535                 540                 


Val Tyr Gln Gln Ile Gly Leu Gly Pro Ile Glu Glu Asp Thr Ile Leu 
545                 550                 555                 560 


Val Ile Asp Pro Asn Asn Ala Ala Val Leu Gln Ser Ser Gly Lys Asn 
                565                 570                 575     


Leu Phe Tyr Leu Pro His Gly Leu Ser Ile Asp Lys Asp Gly Asn Tyr 
            580                 585                 590         


Trp Val Thr Asp Val Ala Leu His Gln Val Phe Lys Leu Asp Pro Asn 
        595                 600                 605             


Asn Lys Glu Gly Pro Val Leu Ile Leu Gly Arg Ser Met Gln Pro Gly 
    610                 615                 620                 


Ser Asp Gln Asn His Phe Cys Gln Pro Thr Asp Val Ala Val Asp Pro 
625                 630                 635                 640 


Gly Thr Gly Ala Ile Tyr Val Ser Asp Gly Tyr Cys Asn Ser Arg Ile 
                645                 650                 655     


Val Gln Phe Ser Pro Ser Gly Lys Phe Ile Thr Gln Trp Gly Glu Glu 
            660                 665                 670         


Ser Ser Gly Ser Ser Pro Leu Pro Gly Gln Phe Thr Val Pro His Ser 
        675                 680                 685             


Leu Ala Leu Val Pro Leu Leu Gly Gln Leu Cys Val Ala Asp Arg Glu 
    690                 695                 700                 


Asn Gly Arg Ile Gln Cys Phe Lys Thr Asp Thr Lys Glu Phe Val Arg 
705                 710                 715                 720 


Glu Ile Lys His Ser Ser Phe Gly Arg Asn Val Phe Ala Ile Ser Tyr 
                725                 730                 735     


Ile Pro Gly Leu Leu Phe Ala Val Asn Gly Lys Pro His Phe Gly Asp 
            740                 745                 750         


Gln Glu Pro Val Gln Gly Phe Val Met Asn Phe Ser Asn Gly Glu Ile 
        755                 760                 765             


Ile Asp Ile Phe Lys Pro Val Arg Lys His Phe Asp Met Pro His Asp 
    770                 775                 780                 


Ile Val Ala Ser Glu Asp Gly Thr Val Tyr Ile Gly Asp Ala His Thr 
785                 790                 795                 800 


Asn Thr Val Trp Lys Phe Thr Leu Thr Glu Lys Leu Glu His Arg Ser 
                805                 810                 815     


Val Lys Lys Ala Gly Ile Glu Val Gln Glu Ile Lys Glu Ala Glu Ala 
            820                 825                 830         


Val Val Glu Thr Lys Met Glu Asn Lys Pro Thr Ser Ser Glu Leu Gln 
        835                 840                 845             


Lys Met Gln Glu Lys Gln Lys Leu Ile Lys Glu Pro Gly Ser Gly Val 
    850                 855                 860                 


Pro Val Val Leu Ile Thr Thr Leu Leu Val Ile Pro Val Val Val Leu 
865                 870                 875                 880 


Leu Ala Ile Ala Ile Phe Ile Arg Trp Lys Lys Ser Arg Ala Phe Gly 
                885                 890                 895     


Ala Asp Ser Glu His Lys Leu Glu Thr Ser Ser Gly Arg Val Leu Gly 
            900                 905                 910         


Arg Phe Arg Gly Lys Gly Ser Gly Gly Leu Asn Leu Gly Asn Phe Phe 
        915                 920                 925             


Ala Ser Arg Lys Gly Tyr Ser Arg Lys Gly Phe Asp Arg Leu Ser Thr 
    930                 935                 940                 


Glu Gly Ser Asp Gln Glu Lys Glu Asp Asp Gly Ser Glu Ser Glu Glu 
945                 950                 955                 960 


Glu Tyr Ser Ala Pro Leu Pro Ala Leu Ala Pro Ser Ser Ser 
                965                 970                 


<210>  9971
<211>  887
<212>  PRT
<213>  Homo Sapiens

<400>  9971

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
1               5                   10                  15      


Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe Lys Arg Phe Lys 
            20                  25                  30          


Glu Thr Thr Arg Pro Phe Ser Asn Glu Cys Leu Gly Thr Thr Arg Pro 
        35                  40                  45              


Val Val Pro Ile Asp Ser Ser Asp Phe Ala Leu Asp Ile Arg Met Pro 
    50                  55                  60                  


Gly Val Thr Pro Lys Gln Ser Asp Thr Tyr Phe Cys Met Ser Met Arg 
65                  70                  75                  80  


Ile Pro Val Asp Glu Glu Ala Phe Val Ile Asp Phe Lys Pro Arg Ala 
                85                  90                  95      


Ser Met Asp Thr Val His His Met Leu Leu Phe Gly Cys Asn Met Pro 
            100                 105                 110         


Ser Ser Thr Gly Ser Tyr Trp Phe Cys Asp Glu Gly Thr Cys Thr Asp 
        115                 120                 125             


Lys Ala Asn Ile Leu Tyr Ala Trp Ala Arg Asn Ala Pro Pro Thr Arg 
    130                 135                 140                 


Leu Pro Lys Gly Val Gly Phe Arg Val Gly Gly Glu Thr Gly Ser Lys 
145                 150                 155                 160 


Tyr Phe Val Leu Gln Val His Tyr Gly Asp Ile Ser Ala Phe Arg Asp 
                165                 170                 175     


Asn Asn Lys Asp Cys Ser Gly Val Ser Leu His Leu Thr Arg Leu Pro 
            180                 185                 190         


Gln Pro Leu Ile Ala Gly Met Tyr Leu Met Met Ser Val Asp Thr Val 
        195                 200                 205             


Ile Pro Ala Gly Glu Lys Val Val Asn Ser Asp Ile Ser Cys His Tyr 
    210                 215                 220                 


Lys Asn Tyr Pro Met His Val Phe Ala Tyr Arg Val His Thr His His 
225                 230                 235                 240 


Leu Gly Lys Val Val Ser Gly Tyr Arg Val Arg Asn Gly Gln Trp Thr 
                245                 250                 255     


Leu Ile Gly Arg Gln Ser Pro Gln Leu Pro Gln Ala Phe Tyr Pro Val 
            260                 265                 270         


Gly His Pro Val Asp Val Ser Phe Gly Asp Leu Leu Ala Ala Arg Cys 
        275                 280                 285             


Val Phe Thr Gly Glu Gly Arg Thr Glu Ala Thr His Ile Gly Gly Thr 
    290                 295                 300                 


Ser Ser Asp Glu Met Cys Asn Leu Tyr Ile Met Tyr Tyr Met Glu Ala 
305                 310                 315                 320 


Lys His Ala Val Ser Phe Met Thr Cys Thr Gln Asn Val Ala Pro Asp 
                325                 330                 335     


Met Phe Arg Thr Ile Pro Pro Glu Ala Asn Ile Pro Ile Pro Val Lys 
            340                 345                 350         


Ser Asp Met Val Met Met His Glu His His Lys Glu Thr Glu Tyr Lys 
        355                 360                 365             


Asp Lys Ile Pro Leu Leu Gln Gln Pro Lys Arg Glu Glu Glu Glu Val 
    370                 375                 380                 


Leu Asp Gln Gly Asp Phe Tyr Ser Leu Leu Ser Lys Leu Leu Gly Glu 
385                 390                 395                 400 


Arg Glu Asp Val Val His Val His Lys Tyr Asn Pro Thr Glu Lys Ala 
                405                 410                 415     


Glu Ser Glu Ser Asp Leu Val Ala Glu Ile Ala Asn Val Val Gln Lys 
            420                 425                 430         


Lys Asp Leu Gly Arg Ser Asp Ala Arg Glu Gly Ala Glu His Glu Arg 
        435                 440                 445             


Gly Asn Ala Ile Leu Val Arg Asp Arg Ile His Lys Phe His Arg Leu 
    450                 455                 460                 


Val Ser Thr Leu Arg Pro Pro Glu Ser Arg Val Phe Ser Leu Gln Gln 
465                 470                 475                 480 


Pro Pro Pro Gly Glu Gly Thr Trp Glu Pro Glu His Thr Gly Asp Phe 
                485                 490                 495     


His Met Glu Glu Ala Leu Asp Trp Pro Gly Val Tyr Leu Leu Pro Gly 
            500                 505                 510         


Gln Val Ser Gly Val Ala Leu Asp Pro Lys Asn Asn Leu Val Ile Phe 
        515                 520                 525             


His Arg Gly Asp His Val Trp Asp Gly Asn Ser Phe Asp Ser Lys Phe 
    530                 535                 540                 


Val Tyr Gln Gln Ile Gly Leu Gly Pro Ile Glu Glu Asp Thr Ile Leu 
545                 550                 555                 560 


Val Ile Asp Pro Asn Asn Ala Ala Val Leu Gln Ser Ser Gly Lys Asn 
                565                 570                 575     


Leu Phe Tyr Leu Pro His Gly Leu Ser Ile Asp Lys Asp Gly Asn Tyr 
            580                 585                 590         


Trp Val Thr Asp Val Ala Leu His Gln Val Phe Lys Leu Asp Pro Asn 
        595                 600                 605             


Asn Lys Glu Gly Pro Val Leu Ile Leu Gly Arg Ser Met Gln Pro Gly 
    610                 615                 620                 


Ser Asp Gln Asn His Phe Cys Gln Pro Thr Asp Val Ala Val Asp Pro 
625                 630                 635                 640 


Gly Thr Gly Ala Ile Tyr Val Ser Asp Gly Tyr Cys Asn Ser Arg Ile 
                645                 650                 655     


Val Gln Phe Ser Pro Ser Gly Lys Phe Ile Thr Gln Trp Gly Glu Glu 
            660                 665                 670         


Ser Ser Gly Ser Ser Pro Leu Pro Gly Gln Phe Thr Val Pro His Ser 
        675                 680                 685             


Leu Ala Leu Val Pro Leu Leu Gly Gln Leu Cys Val Ala Asp Arg Glu 
    690                 695                 700                 


Asn Gly Arg Ile Gln Cys Phe Lys Thr Asp Thr Lys Glu Phe Val Arg 
705                 710                 715                 720 


Glu Ile Lys His Ser Ser Phe Gly Arg Asn Val Phe Ala Ile Ser Tyr 
                725                 730                 735     


Ile Pro Gly Leu Leu Phe Ala Val Asn Gly Lys Pro His Phe Gly Asp 
            740                 745                 750         


Gln Glu Pro Val Gln Gly Phe Val Met Asn Phe Ser Asn Gly Glu Ile 
        755                 760                 765             


Ile Asp Ile Phe Lys Pro Val Arg Lys His Phe Asp Met Pro His Asp 
    770                 775                 780                 


Ile Val Ala Ser Glu Asp Gly Thr Val Tyr Ile Gly Asp Ala His Thr 
785                 790                 795                 800 


Asn Thr Val Trp Lys Phe Thr Leu Thr Glu Lys Leu Glu His Arg Ser 
                805                 810                 815     


Val Lys Lys Ala Gly Ile Glu Val Gln Glu Ile Lys Gly Lys Gly Ser 
            820                 825                 830         


Gly Gly Leu Asn Leu Gly Asn Phe Phe Ala Ser Arg Lys Gly Tyr Ser 
        835                 840                 845             


Arg Lys Gly Phe Asp Arg Leu Ser Thr Glu Gly Ser Asp Gln Glu Lys 
    850                 855                 860                 


Glu Asp Asp Gly Ser Glu Ser Glu Glu Glu Tyr Ser Ala Pro Leu Pro 
865                 870                 875                 880 


Ala Leu Ala Pro Ser Ser Ser 
                885         


<210>  9972
<211>  866
<212>  PRT
<213>  Homo Sapiens

<400>  9972

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
1               5                   10                  15      


Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe Lys Arg Phe Lys 
            20                  25                  30          


Glu Thr Thr Arg Pro Phe Ser Asn Glu Cys Leu Gly Thr Thr Arg Pro 
        35                  40                  45              


Val Val Pro Ile Asp Ser Ser Asp Phe Ala Leu Asp Ile Arg Met Pro 
    50                  55                  60                  


Gly Val Thr Pro Lys Gln Ser Asp Thr Tyr Phe Cys Met Ser Met Arg 
65                  70                  75                  80  


Ile Pro Val Asp Glu Glu Ala Phe Val Ile Asp Phe Lys Pro Arg Ala 
                85                  90                  95      


Ser Met Asp Thr Val His His Met Leu Leu Phe Gly Cys Asn Met Pro 
            100                 105                 110         


Ser Ser Thr Gly Ser Tyr Trp Phe Cys Asp Glu Gly Thr Cys Thr Asp 
        115                 120                 125             


Lys Ala Asn Ile Leu Tyr Ala Trp Ala Arg Asn Ala Pro Pro Thr Arg 
    130                 135                 140                 


Leu Pro Lys Gly Val Gly Phe Arg Val Gly Gly Glu Thr Gly Ser Lys 
145                 150                 155                 160 


Tyr Phe Val Leu Gln Val His Tyr Gly Asp Ile Ser Ala Phe Arg Asp 
                165                 170                 175     


Asn Asn Lys Asp Cys Ser Gly Val Ser Leu His Leu Thr Arg Leu Pro 
            180                 185                 190         


Gln Pro Leu Ile Ala Gly Met Tyr Leu Met Met Ser Val Asp Thr Val 
        195                 200                 205             


Ile Pro Ala Gly Glu Lys Val Val Asn Ser Asp Ile Ser Cys His Tyr 
    210                 215                 220                 


Lys Asn Tyr Pro Met His Val Phe Ala Tyr Arg Val His Thr His His 
225                 230                 235                 240 


Leu Gly Lys Val Val Ser Gly Tyr Arg Val Arg Asn Gly Gln Trp Thr 
                245                 250                 255     


Leu Ile Gly Arg Gln Ser Pro Gln Leu Pro Gln Ala Phe Tyr Pro Val 
            260                 265                 270         


Gly His Pro Val Asp Val Ser Phe Gly Asp Leu Leu Ala Ala Arg Cys 
        275                 280                 285             


Val Phe Thr Gly Glu Gly Arg Thr Glu Ala Thr His Ile Gly Gly Thr 
    290                 295                 300                 


Ser Ser Asp Glu Met Cys Asn Leu Tyr Ile Met Tyr Tyr Met Glu Ala 
305                 310                 315                 320 


Lys His Ala Val Ser Phe Met Thr Cys Thr Gln Asn Val Ala Pro Asp 
                325                 330                 335     


Met Phe Arg Thr Ile Pro Pro Glu Ala Asn Ile Pro Ile Pro Val Lys 
            340                 345                 350         


Ser Asp Met Val Met Met His Glu His His Lys Glu Thr Glu Tyr Lys 
        355                 360                 365             


Asp Lys Ile Pro Leu Leu Gln Gln Pro Lys Arg Glu Glu Glu Glu Val 
    370                 375                 380                 


Leu Asp Gln Asp Phe His Met Glu Glu Ala Leu Asp Trp Pro Gly Val 
385                 390                 395                 400 


Tyr Leu Leu Pro Gly Gln Val Ser Gly Val Ala Leu Asp Pro Lys Asn 
                405                 410                 415     


Asn Leu Val Ile Phe His Arg Gly Asp His Val Trp Asp Gly Asn Ser 
            420                 425                 430         


Phe Asp Ser Lys Phe Val Tyr Gln Gln Ile Gly Leu Gly Pro Ile Glu 
        435                 440                 445             


Glu Asp Thr Ile Leu Val Ile Asp Pro Asn Asn Ala Ala Val Leu Gln 
    450                 455                 460                 


Ser Ser Gly Lys Asn Leu Phe Tyr Leu Pro His Gly Leu Ser Ile Asp 
465                 470                 475                 480 


Lys Asp Gly Asn Tyr Trp Val Thr Asp Val Ala Leu His Gln Val Phe 
                485                 490                 495     


Lys Leu Asp Pro Asn Asn Lys Glu Gly Pro Val Leu Ile Leu Gly Arg 
            500                 505                 510         


Ser Met Gln Pro Gly Ser Asp Gln Asn His Phe Cys Gln Pro Thr Asp 
        515                 520                 525             


Val Ala Val Asp Pro Gly Thr Gly Ala Ile Tyr Val Ser Asp Gly Tyr 
    530                 535                 540                 


Cys Asn Ser Arg Ile Val Gln Phe Ser Pro Ser Gly Lys Phe Ile Thr 
545                 550                 555                 560 


Gln Trp Gly Glu Glu Ser Ser Gly Ser Ser Pro Leu Pro Gly Gln Phe 
                565                 570                 575     


Thr Val Pro His Ser Leu Ala Leu Val Pro Leu Leu Gly Gln Leu Cys 
            580                 585                 590         


Val Ala Asp Arg Glu Asn Gly Arg Ile Gln Cys Phe Lys Thr Asp Thr 
        595                 600                 605             


Lys Glu Phe Val Arg Glu Ile Lys His Ser Ser Phe Gly Arg Asn Val 
    610                 615                 620                 


Phe Ala Ile Ser Tyr Ile Pro Gly Leu Leu Phe Ala Val Asn Gly Lys 
625                 630                 635                 640 


Pro His Phe Gly Asp Gln Glu Pro Val Gln Gly Phe Val Met Asn Phe 
                645                 650                 655     


Ser Asn Gly Glu Ile Ile Asp Ile Phe Lys Pro Val Arg Lys His Phe 
            660                 665                 670         


Asp Met Pro His Asp Ile Val Ala Ser Glu Asp Gly Thr Val Tyr Ile 
        675                 680                 685             


Gly Asp Ala His Thr Asn Thr Val Trp Lys Phe Thr Leu Thr Glu Lys 
    690                 695                 700                 


Leu Glu His Arg Ser Val Lys Lys Ala Gly Ile Glu Val Gln Glu Ile 
705                 710                 715                 720 


Lys Glu Ala Glu Ala Val Val Glu Thr Lys Met Glu Asn Lys Pro Thr 
                725                 730                 735     


Ser Ser Glu Leu Gln Lys Met Gln Glu Lys Gln Lys Leu Ile Lys Glu 
            740                 745                 750         


Pro Gly Ser Gly Val Pro Val Val Leu Ile Thr Thr Leu Leu Val Ile 
        755                 760                 765             


Pro Val Val Val Leu Leu Ala Ile Ala Ile Phe Ile Arg Trp Lys Lys 
    770                 775                 780                 


Ser Arg Ala Phe Gly Asp Ser Glu His Lys Leu Glu Thr Ser Ser Gly 
785                 790                 795                 800 


Arg Val Leu Gly Arg Phe Arg Gly Lys Gly Ser Gly Gly Leu Asn Leu 
                805                 810                 815     


Gly Asn Phe Phe Ala Ser Arg Lys Gly Tyr Ser Arg Lys Gly Phe Asp 
            820                 825                 830         


Arg Leu Ser Thr Glu Gly Ser Asp Gln Glu Lys Glu Asp Asp Gly Ser 
        835                 840                 845             


Glu Ser Glu Glu Glu Tyr Ser Ala Pro Leu Pro Ala Leu Ala Pro Ser 
    850                 855                 860                 


Ser Ser 
865     


<210>  9973
<211>  905
<212>  PRT
<213>  Homo Sapiens

<400>  9973

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
1               5                   10                  15      


Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe Lys Arg Phe Lys 
            20                  25                  30          


Glu Thr Thr Arg Pro Phe Ser Asn Glu Cys Leu Gly Thr Thr Arg Pro 
        35                  40                  45              


Val Val Pro Ile Asp Ser Ser Asp Phe Ala Leu Asp Ile Arg Met Pro 
    50                  55                  60                  


Gly Val Thr Pro Lys Gln Ser Asp Thr Tyr Phe Cys Met Ser Met Arg 
65                  70                  75                  80  


Ile Pro Val Asp Glu Glu Ala Phe Val Ile Asp Phe Lys Pro Arg Ala 
                85                  90                  95      


Ser Met Asp Thr Val His His Met Leu Leu Phe Gly Cys Asn Met Pro 
            100                 105                 110         


Ser Ser Thr Gly Ser Tyr Trp Phe Cys Asp Glu Gly Thr Cys Thr Asp 
        115                 120                 125             


Lys Ala Asn Ile Leu Tyr Ala Trp Ala Arg Asn Ala Pro Pro Thr Arg 
    130                 135                 140                 


Leu Pro Lys Gly Val Gly Phe Arg Val Gly Gly Glu Thr Gly Ser Lys 
145                 150                 155                 160 


Tyr Phe Val Leu Gln Val His Tyr Gly Asp Ile Ser Ala Phe Arg Asp 
                165                 170                 175     


Asn Asn Lys Asp Cys Ser Gly Val Ser Leu His Leu Thr Arg Leu Pro 
            180                 185                 190         


Gln Pro Leu Ile Ala Gly Met Tyr Leu Met Met Ser Val Asp Thr Val 
        195                 200                 205             


Ile Pro Ala Gly Glu Lys Val Val Asn Ser Asp Ile Ser Cys His Tyr 
    210                 215                 220                 


Lys Asn Tyr Pro Met His Val Phe Ala Tyr Arg Val His Thr His His 
225                 230                 235                 240 


Leu Gly Lys Val Val Ser Gly Tyr Arg Val Arg Asn Gly Gln Trp Thr 
                245                 250                 255     


Leu Ile Gly Arg Gln Ser Pro Gln Leu Pro Gln Ala Phe Tyr Pro Val 
            260                 265                 270         


Gly His Pro Val Asp Val Ser Phe Gly Asp Leu Leu Ala Ala Arg Cys 
        275                 280                 285             


Val Phe Thr Gly Glu Gly Arg Thr Glu Ala Thr His Ile Gly Gly Thr 
    290                 295                 300                 


Ser Ser Asp Glu Met Cys Asn Leu Tyr Ile Met Tyr Tyr Met Glu Ala 
305                 310                 315                 320 


Lys His Ala Val Ser Phe Met Thr Cys Thr Gln Asn Val Ala Pro Asp 
                325                 330                 335     


Met Phe Arg Thr Ile Pro Pro Glu Ala Asn Ile Pro Ile Pro Val Lys 
            340                 345                 350         


Ser Asp Met Val Met Met His Glu His His Lys Glu Thr Glu Tyr Lys 
        355                 360                 365             


Asp Lys Ile Pro Leu Leu Gln Gln Pro Lys Arg Glu Glu Glu Glu Val 
    370                 375                 380                 


Leu Asp Gln Gly Asp Phe Tyr Ser Leu Leu Ser Lys Leu Leu Gly Glu 
385                 390                 395                 400 


Arg Glu Asp Val Val His Val His Lys Tyr Asn Pro Thr Glu Lys Ala 
                405                 410                 415     


Glu Ser Glu Ser Asp Leu Val Ala Glu Ile Ala Asn Val Val Gln Lys 
            420                 425                 430         


Lys Asp Leu Gly Arg Ser Asp Ala Arg Glu Gly Ala Glu His Glu Arg 
        435                 440                 445             


Gly Asn Ala Ile Leu Val Arg Asp Arg Ile His Lys Phe His Arg Leu 
    450                 455                 460                 


Val Ser Thr Leu Arg Pro Pro Glu Ser Arg Val Phe Ser Leu Gln Gln 
465                 470                 475                 480 


Pro Pro Pro Gly Glu Gly Thr Trp Glu Pro Glu His Thr Gly Asp Phe 
                485                 490                 495     


His Met Glu Glu Ala Leu Asp Trp Pro Gly Val Tyr Leu Leu Pro Gly 
            500                 505                 510         


Gln Val Ser Gly Val Ala Leu Asp Pro Lys Asn Asn Leu Val Ile Phe 
        515                 520                 525             


His Arg Gly Asp His Val Trp Asp Gly Asn Ser Phe Asp Ser Lys Phe 
    530                 535                 540                 


Val Tyr Gln Gln Ile Gly Leu Gly Pro Ile Glu Glu Asp Thr Ile Leu 
545                 550                 555                 560 


Val Ile Asp Pro Asn Asn Ala Ala Val Leu Gln Ser Ser Gly Lys Asn 
                565                 570                 575     


Leu Phe Tyr Leu Pro His Gly Leu Ser Ile Asp Lys Asp Gly Asn Tyr 
            580                 585                 590         


Trp Val Thr Asp Val Ala Leu His Gln Val Phe Lys Leu Asp Pro Asn 
        595                 600                 605             


Asn Lys Glu Gly Pro Val Leu Ile Leu Gly Arg Ser Met Gln Pro Gly 
    610                 615                 620                 


Ser Asp Gln Asn His Phe Cys Gln Pro Thr Asp Val Ala Val Asp Pro 
625                 630                 635                 640 


Gly Thr Gly Ala Ile Tyr Val Ser Asp Gly Tyr Cys Asn Ser Arg Ile 
                645                 650                 655     


Val Gln Phe Ser Pro Ser Gly Lys Phe Ile Thr Gln Trp Gly Glu Glu 
            660                 665                 670         


Ser Ser Gly Ser Ser Pro Leu Pro Gly Gln Phe Thr Val Pro His Ser 
        675                 680                 685             


Leu Ala Leu Val Pro Leu Leu Gly Gln Leu Cys Val Ala Asp Arg Glu 
    690                 695                 700                 


Asn Gly Arg Ile Gln Cys Phe Lys Thr Asp Thr Lys Glu Phe Val Arg 
705                 710                 715                 720 


Glu Ile Lys His Ser Ser Phe Gly Arg Asn Val Phe Ala Ile Ser Tyr 
                725                 730                 735     


Ile Pro Gly Leu Leu Phe Ala Val Asn Gly Lys Pro His Phe Gly Asp 
            740                 745                 750         


Gln Glu Pro Val Gln Gly Phe Val Met Asn Phe Ser Asn Gly Glu Ile 
        755                 760                 765             


Ile Asp Ile Phe Lys Pro Val Arg Lys His Phe Asp Met Pro His Asp 
    770                 775                 780                 


Ile Val Ala Ser Glu Asp Gly Thr Val Tyr Ile Gly Asp Ala His Thr 
785                 790                 795                 800 


Asn Thr Val Trp Lys Phe Thr Leu Thr Glu Lys Leu Glu His Arg Ser 
                805                 810                 815     


Val Lys Lys Ala Gly Ile Glu Val Gln Glu Ile Lys Asp Ser Glu His 
            820                 825                 830         


Lys Leu Glu Thr Ser Ser Gly Arg Val Leu Gly Arg Phe Arg Gly Lys 
        835                 840                 845             


Gly Ser Gly Gly Leu Asn Leu Gly Asn Phe Phe Ala Ser Arg Lys Gly 
    850                 855                 860                 


Tyr Ser Arg Lys Gly Phe Asp Arg Leu Ser Thr Glu Gly Ser Asp Gln 
865                 870                 875                 880 


Glu Lys Glu Asp Asp Gly Ser Glu Ser Glu Glu Glu Tyr Ser Ala Pro 
                885                 890                 895     


Leu Pro Ala Leu Ala Pro Ser Ser Ser 
            900                 905 


<210>  9974
<211>  973
<212>  PRT
<213>  Homo Sapiens

<400>  9974

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
1               5                   10                  15      


Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe Lys Arg Phe Lys 
            20                  25                  30          


Glu Thr Thr Arg Pro Phe Ser Asn Glu Cys Leu Gly Thr Thr Arg Pro 
        35                  40                  45              


Val Val Pro Ile Asp Ser Ser Asp Phe Ala Leu Asp Ile Arg Met Pro 
    50                  55                  60                  


Gly Val Thr Pro Lys Gln Ser Asp Thr Tyr Phe Cys Met Ser Met Arg 
65                  70                  75                  80  


Ile Pro Val Asp Glu Glu Ala Phe Val Ile Asp Phe Lys Pro Arg Ala 
                85                  90                  95      


Ser Met Asp Thr Val His His Met Leu Leu Phe Gly Cys Asn Met Pro 
            100                 105                 110         


Ser Ser Thr Gly Ser Tyr Trp Phe Cys Asp Glu Gly Thr Cys Thr Asp 
        115                 120                 125             


Lys Ala Asn Ile Leu Tyr Ala Trp Ala Arg Asn Ala Pro Pro Thr Arg 
    130                 135                 140                 


Leu Pro Lys Gly Val Gly Phe Arg Val Gly Gly Glu Thr Gly Ser Lys 
145                 150                 155                 160 


Tyr Phe Val Leu Gln Val His Tyr Gly Asp Ile Ser Ala Phe Arg Asp 
                165                 170                 175     


Asn Asn Lys Asp Cys Ser Gly Val Ser Leu His Leu Thr Arg Leu Pro 
            180                 185                 190         


Gln Pro Leu Ile Ala Gly Met Tyr Leu Met Met Ser Val Asp Thr Val 
        195                 200                 205             


Ile Pro Ala Gly Glu Lys Val Val Asn Ser Asp Ile Ser Cys His Tyr 
    210                 215                 220                 


Lys Asn Tyr Pro Met His Val Phe Ala Tyr Arg Val His Thr His His 
225                 230                 235                 240 


Leu Gly Lys Val Val Ser Gly Tyr Arg Val Arg Asn Gly Gln Trp Thr 
                245                 250                 255     


Leu Ile Gly Arg Gln Ser Pro Gln Leu Pro Gln Ala Phe Tyr Pro Val 
            260                 265                 270         


Gly His Pro Val Asp Val Ser Phe Gly Asp Leu Leu Ala Ala Arg Cys 
        275                 280                 285             


Val Phe Thr Gly Glu Gly Arg Thr Glu Ala Thr His Ile Gly Gly Thr 
    290                 295                 300                 


Ser Ser Asp Glu Met Cys Asn Leu Tyr Ile Met Tyr Tyr Met Glu Ala 
305                 310                 315                 320 


Lys His Ala Val Ser Phe Met Thr Cys Thr Gln Asn Val Ala Pro Asp 
                325                 330                 335     


Met Phe Arg Thr Ile Pro Pro Glu Ala Asn Ile Pro Ile Pro Val Lys 
            340                 345                 350         


Ser Asp Met Val Met Met His Glu His His Lys Glu Thr Glu Tyr Lys 
        355                 360                 365             


Asp Lys Ile Pro Leu Leu Gln Gln Pro Lys Arg Glu Glu Glu Glu Val 
    370                 375                 380                 


Leu Asp Gln Gly Asp Phe Tyr Ser Leu Leu Ser Lys Leu Leu Gly Glu 
385                 390                 395                 400 


Arg Glu Asp Val Val His Val His Lys Tyr Asn Pro Thr Glu Lys Ala 
                405                 410                 415     


Glu Ser Glu Ser Asp Leu Val Ala Glu Ile Ala Asn Val Val Gln Lys 
            420                 425                 430         


Lys Asp Leu Gly Arg Ser Asp Ala Arg Glu Gly Ala Glu His Glu Arg 
        435                 440                 445             


Gly Asn Ala Ile Leu Val Arg Asp Arg Ile His Lys Phe His Arg Leu 
    450                 455                 460                 


Val Ser Thr Leu Arg Pro Pro Glu Ser Arg Val Phe Ser Leu Gln Gln 
465                 470                 475                 480 


Pro Pro Pro Gly Glu Gly Thr Trp Glu Pro Glu His Thr Gly Asp Phe 
                485                 490                 495     


His Met Glu Glu Ala Leu Asp Trp Pro Gly Val Tyr Leu Leu Pro Gly 
            500                 505                 510         


Gln Val Ser Gly Val Ala Leu Asp Pro Lys Asn Asn Leu Val Ile Phe 
        515                 520                 525             


His Arg Gly Asp His Val Trp Asp Gly Asn Ser Phe Asp Ser Lys Phe 
    530                 535                 540                 


Val Tyr Gln Gln Ile Gly Leu Gly Pro Ile Glu Glu Asp Thr Ile Leu 
545                 550                 555                 560 


Val Ile Asp Pro Asn Asn Ala Ala Val Leu Gln Ser Ser Gly Lys Asn 
                565                 570                 575     


Leu Phe Tyr Leu Pro His Gly Leu Ser Ile Asp Lys Asp Gly Asn Tyr 
            580                 585                 590         


Trp Val Thr Asp Val Ala Leu His Gln Val Phe Lys Leu Asp Pro Asn 
        595                 600                 605             


Asn Lys Glu Gly Pro Val Leu Ile Leu Gly Arg Ser Met Gln Pro Gly 
    610                 615                 620                 


Ser Asp Gln Asn His Phe Cys Gln Pro Thr Asp Val Ala Val Asp Pro 
625                 630                 635                 640 


Gly Thr Gly Ala Ile Tyr Val Ser Asp Gly Tyr Cys Asn Ser Arg Ile 
                645                 650                 655     


Val Gln Phe Ser Pro Ser Gly Lys Phe Ile Thr Gln Trp Gly Glu Glu 
            660                 665                 670         


Ser Ser Gly Ser Ser Pro Leu Pro Gly Gln Phe Thr Val Pro His Ser 
        675                 680                 685             


Leu Ala Leu Val Pro Leu Leu Gly Gln Leu Cys Val Ala Asp Arg Glu 
    690                 695                 700                 


Asn Gly Arg Ile Gln Cys Phe Lys Thr Asp Thr Lys Glu Phe Val Arg 
705                 710                 715                 720 


Glu Ile Lys His Ser Ser Phe Gly Arg Asn Val Phe Ala Ile Ser Tyr 
                725                 730                 735     


Ile Pro Gly Leu Leu Phe Ala Val Asn Gly Lys Pro His Phe Gly Asp 
            740                 745                 750         


Gln Glu Pro Val Gln Gly Phe Val Met Asn Phe Ser Asn Gly Glu Ile 
        755                 760                 765             


Ile Asp Ile Phe Lys Pro Val Arg Lys His Phe Asp Met Pro His Asp 
    770                 775                 780                 


Ile Val Ala Ser Glu Asp Gly Thr Val Tyr Ile Gly Asp Ala His Thr 
785                 790                 795                 800 


Asn Thr Val Trp Lys Phe Thr Leu Thr Glu Lys Leu Glu His Arg Ser 
                805                 810                 815     


Val Lys Lys Ala Gly Ile Glu Val Gln Glu Ile Lys Glu Ala Glu Ala 
            820                 825                 830         


Val Val Glu Thr Lys Met Glu Asn Lys Pro Thr Ser Ser Glu Leu Gln 
        835                 840                 845             


Lys Met Gln Glu Lys Gln Lys Leu Ile Lys Glu Pro Gly Ser Gly Val 
    850                 855                 860                 


Pro Val Val Leu Ile Thr Thr Leu Leu Val Ile Pro Val Val Val Leu 
865                 870                 875                 880 


Leu Ala Ile Ala Ile Phe Ile Arg Trp Lys Lys Ser Arg Ala Phe Gly 
                885                 890                 895     


Asp Ser Glu His Lys Leu Glu Thr Ser Ser Gly Arg Val Leu Gly Arg 
            900                 905                 910         


Phe Arg Gly Lys Gly Ser Gly Gly Leu Asn Leu Gly Asn Phe Phe Ala 
        915                 920                 925             


Ser Arg Lys Gly Tyr Ser Arg Lys Gly Phe Asp Arg Leu Ser Thr Glu 
    930                 935                 940                 


Gly Ser Asp Gln Glu Lys Glu Asp Asp Gly Ser Glu Ser Glu Glu Glu 
945                 950                 955                 960 


Tyr Ser Ala Pro Leu Pro Ala Leu Ala Pro Ser Ser Ser 
                965                 970             


<210>  9975
<211>  679
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9975

Xaa Met His Val Phe Ala Tyr Arg Val His Thr His His Leu Gly Lys 
1               5                   10                  15      


Val Val Ser Gly Tyr Arg Val Arg Asn Gly Gln Trp Thr Leu Ile Gly 
            20                  25                  30          


Arg Gln Ser Pro Gln Leu Pro Gln Ala Phe Tyr Pro Val Gly His Pro 
        35                  40                  45              


Val Asp Val Ser Phe Gly Asp Leu Leu Ala Ala Arg Cys Val Phe Thr 
    50                  55                  60                  


Gly Glu Gly Arg Thr Glu Ala Thr His Ile Gly Gly Thr Ser Ser Asp 
65                  70                  75                  80  


Glu Met Cys Asn Leu Tyr Ile Met Tyr Tyr Met Glu Ala Lys His Ala 
                85                  90                  95      


Val Ser Phe Met Thr Cys Thr Gln Asn Val Ala Pro Asp Met Phe Arg 
            100                 105                 110         


Thr Ile Pro Pro Glu Ala Asn Ile Pro Ile Pro Val Lys Ser Asp Met 
        115                 120                 125             


Val Met Met His Glu His His Lys Glu Thr Glu Tyr Lys Asp Lys Ile 
    130                 135                 140                 


Pro Leu Leu Gln Gln Pro Lys Arg Glu Glu Glu Glu Val Leu Asp Gln 
145                 150                 155                 160 


Gly Asp Phe Tyr Ser Leu Leu Ser Lys Leu Leu Gly Glu Arg Glu Asp 
                165                 170                 175     


Val Val His Val His Lys Tyr Asn Pro Thr Glu Lys Ala Glu Ser Glu 
            180                 185                 190         


Ser Asp Leu Val Ala Glu Ile Ala Asn Val Val Gln Lys Lys Asp Leu 
        195                 200                 205             


Gly Arg Ser Asp Ala Arg Glu Gly Ala Glu His Glu Arg Gly Asn Ala 
    210                 215                 220                 


Ile Leu Val Arg Asp Arg Ile His Lys Phe His Arg Leu Val Ser Thr 
225                 230                 235                 240 


Leu Arg Pro Pro Glu Ser Arg Val Phe Ser Leu Gln Gln Pro Pro Pro 
                245                 250                 255     


Gly Glu Gly Thr Trp Glu Pro Glu His Thr Gly Asp Phe His Met Glu 
            260                 265                 270         


Glu Ala Leu Asp Trp Pro Gly Val Tyr Leu Leu Pro Gly Gln Val Ser 
        275                 280                 285             


Gly Val Ala Leu Asp Pro Lys Asn Asn Leu Val Ile Phe His Arg Gly 
    290                 295                 300                 


Asp His Val Trp Asp Gly Asn Ser Phe Asp Ser Lys Phe Val Tyr Gln 
305                 310                 315                 320 


Gln Ile Gly Leu Gly Pro Ile Glu Glu Asp Thr Ile Leu Val Ile Asp 
                325                 330                 335     


Pro Asn Asn Ala Ala Val Leu Gln Ser Ser Gly Lys Asn Leu Phe Tyr 
            340                 345                 350         


Leu Pro His Gly Leu Ser Ile Asp Lys Asp Gly Asn Tyr Trp Val Thr 
        355                 360                 365             


Asp Val Ala Leu His Gln Val Phe Lys Leu Asp Pro Asn Asn Lys Glu 
    370                 375                 380                 


Gly Pro Val Leu Ile Leu Gly Arg Ser Met Gln Pro Gly Ser Asp Gln 
385                 390                 395                 400 


Asn His Phe Cys Gln Pro Thr Asp Val Ala Val Asp Pro Gly Thr Gly 
                405                 410                 415     


Ala Ile Tyr Val Ser Asp Gly Tyr Cys Asn Ser Arg Ile Val Gln Phe 
            420                 425                 430         


Ser Pro Ser Gly Lys Phe Ile Thr Gln Trp Gly Glu Glu Ser Ser Gly 
        435                 440                 445             


Ser Ser Pro Leu Pro Gly Gln Phe Thr Val Pro His Ser Leu Ala Leu 
    450                 455                 460                 


Val Pro Leu Leu Gly Gln Leu Cys Val Ala Asp Arg Glu Asn Gly Arg 
465                 470                 475                 480 


Ile Gln Cys Phe Lys Thr Asp Thr Lys Glu Phe Val Arg Glu Ile Lys 
                485                 490                 495     


His Ser Ser Phe Gly Arg Asn Val Phe Ala Ile Ser Tyr Ile Pro Gly 
            500                 505                 510         


Leu Leu Phe Ala Val Asn Gly Lys Pro His Phe Gly Asp Gln Glu Pro 
        515                 520                 525             


Val Gln Gly Phe Val Met Asn Phe Ser Asn Gly Glu Ile Ile Asp Ile 
    530                 535                 540                 


Phe Lys Pro Val Arg Lys His Phe Asp Met Pro His Asp Ile Val Ala 
545                 550                 555                 560 


Ser Glu Asp Gly Thr Val Tyr Ile Gly Asp Ala His Thr Asn Thr Val 
                565                 570                 575     


Trp Lys Phe Thr Leu Thr Glu Lys Leu Glu His Arg Ser Val Lys Lys 
            580                 585                 590         


Ala Gly Ile Glu Val Gln Glu Ile Lys Ala Asp Ser Glu His Lys Leu 
        595                 600                 605             


Glu Thr Ser Ser Gly Arg Val Leu Gly Arg Phe Arg Gly Lys Gly Ser 
    610                 615                 620                 


Gly Gly Leu Asn Leu Gly Asn Phe Phe Ala Ser Arg Lys Gly Tyr Ser 
625                 630                 635                 640 


Arg Lys Gly Phe Asp Arg Leu Ser Thr Glu Gly Ser Asp Gln Glu Lys 
                645                 650                 655     


Glu Asp Asp Gly Ser Glu Ser Glu Glu Glu Tyr Ser Ala Pro Leu Pro 
            660                 665                 670         


Ala Leu Ala Pro Ser Ser Ser 
        675                 


<210>  9976
<211>  250
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9976

Xaa Arg Ile Gln Cys Phe Lys Thr Asp Thr Lys Glu Phe Val Arg Glu 
1               5                   10                  15      


Ile Lys His Ser Ser Phe Gly Arg Asn Val Phe Ala Ile Ser Tyr Ile 
            20                  25                  30          


Pro Gly Leu Leu Phe Ala Val Asn Gly Lys Pro His Phe Gly Asp Gln 
        35                  40                  45              


Glu Pro Val Gln Gly Phe Val Met Asn Phe Ser Asn Gly Glu Ile Ile 
    50                  55                  60                  


Asp Ile Phe Lys Pro Val Arg Lys His Phe Asp Met Pro His Asp Ile 
65                  70                  75                  80  


Val Ala Ser Glu Asp Gly Thr Val Tyr Ile Gly Asp Ala His Thr Asn 
                85                  90                  95      


Thr Val Trp Lys Phe Thr Leu Thr Glu Lys Leu Glu His Arg Ser Val 
            100                 105                 110         


Lys Lys Ala Gly Ile Glu Val Gln Glu Ile Lys Glu Ala Glu Ala Val 
        115                 120                 125             


Val Glu Thr Lys Met Glu Asn Lys Pro Thr Ser Ser Glu Leu Gln Lys 
    130                 135                 140                 


Met Gln Glu Lys Gln Lys Leu Ile Lys Glu Pro Gly Ser Gly Val Pro 
145                 150                 155                 160 


Val Val Leu Ile Thr Thr Leu Leu Val Ile Pro Val Val Val Leu Leu 
                165                 170                 175     


Ala Ile Ala Ile Phe Ile Arg Trp Lys Lys Ser Arg Ala Phe Gly Gly 
            180                 185                 190         


Lys Gly Ser Gly Gly Leu Asn Leu Gly Asn Phe Phe Ala Ser Arg Lys 
        195                 200                 205             


Gly Tyr Ser Arg Lys Gly Phe Asp Arg Leu Ser Thr Glu Gly Ser Asp 
    210                 215                 220                 


Gln Glu Lys Glu Asp Asp Gly Ser Glu Ser Glu Glu Glu Tyr Ser Ala 
225                 230                 235                 240 


Pro Leu Pro Ala Leu Ala Pro Ser Ser Ser 
                245                 250 


<210>  9977
<211>  675
<212>  PRT
<213>  Homo Sapiens

<400>  9977

Met Cys Arg Glu Cys Cys Glu Tyr Asp Gln Ile Glu Cys Val Cys Pro 
1               5                   10                  15      


Gly Lys Arg Glu Val Val Gly Tyr Thr Ile Pro Cys Cys Arg Asn Glu 
            20                  25                  30          


Glu Asn Glu Cys Asp Ser Cys Leu Ile His Pro Gly Cys Thr Ile Phe 
        35                  40                  45              


Glu Asn Cys Lys Ser Cys Arg Asn Gly Ser Trp Gly Gly Thr Leu Asp 
    50                  55                  60                  


Asp Phe Tyr Val Lys Gly Phe Tyr Cys Ala Glu Cys Arg Ala Gly Trp 
65                  70                  75                  80  


Tyr Gly Gly Asp Cys Met Arg Cys Gly Gln Val Leu Arg Ala Pro Lys 
                85                  90                  95      


Gly Gln Ile Leu Leu Glu Ser Tyr Pro Leu Asn Ala His Cys Glu Trp 
            100                 105                 110         


Thr Ile His Ala Lys Pro Gly Phe Val Ile Gln Leu Arg Phe Val Met 
        115                 120                 125             


Leu Ser Leu Glu Phe Asp Tyr Met Cys Gln Tyr Asp Tyr Val Glu Val 
    130                 135                 140                 


Arg Asp Gly Asp Asn Arg Asp Gly Gln Ile Ile Lys Arg Val Cys Gly 
145                 150                 155                 160 


Asn Glu Arg Pro Ala Pro Ile Gln Ser Ile Gly Ser Ser Leu His Val 
                165                 170                 175     


Leu Phe His Ser Asp Gly Ser Lys Asn Phe Asp Gly Phe His Ala Ile 
            180                 185                 190         


Tyr Glu Glu Ile Thr Ala Cys Ser Ser Ser Pro Cys Phe His Asp Gly 
        195                 200                 205             


Thr Cys Val Leu Asp Lys Ala Gly Ser Tyr Lys Cys Ala Cys Leu Ala 
    210                 215                 220                 


Gly Tyr Thr Gly Gln Arg Cys Glu Asn Leu Leu Glu Ala Gly Lys Ser 
225                 230                 235                 240 


Lys Ile Lys Ala Ser Glu Asp Ser Leu Ser Val Leu Glu Glu Arg Asn 
                245                 250                 255     


Cys Ser Asp Pro Gly Gly Pro Val Asn Gly Tyr Gln Lys Ile Thr Gly 
            260                 265                 270         


Gly Pro Gly Leu Ile Asn Gly Arg His Ala Lys Ile Gly Thr Val Val 
        275                 280                 285             


Ser Phe Phe Cys Asn Asn Ser Tyr Val Leu Ser Gly Asn Glu Lys Arg 
    290                 295                 300                 


Thr Cys Gln Gln Asn Gly Glu Trp Ser Gly Lys Gln Pro Ile Cys Ile 
305                 310                 315                 320 


Lys Ala Cys Arg Glu Pro Lys Ile Ser Asp Leu Val Arg Arg Arg Val 
                325                 330                 335     


Leu Pro Met Gln Val Gln Ser Arg Glu Thr Pro Leu His Gln Leu Tyr 
            340                 345                 350         


Ser Ala Ala Phe Ser Lys Gln Lys Leu Gln Ser Ala Pro Thr Lys Lys 
        355                 360                 365             


Pro Ala Leu Pro Phe Gly Asp Leu Pro Met Gly Tyr Gln His Leu His 
    370                 375                 380                 


Thr Gln Leu Gln Tyr Glu Cys Ile Ser Pro Phe Tyr Arg Arg Leu Gly 
385                 390                 395                 400 


Ser Ser Arg Arg Thr Cys Leu Arg Thr Gly Lys Trp Ser Gly Arg Ala 
                405                 410                 415     


Pro Ser Cys Ile Pro Ile Cys Gly Lys Ile Glu Asn Ile Thr Ala Pro 
            420                 425                 430         


Lys Thr Gln Gly Leu Arg Trp Pro Trp Gln Ala Ala Ile Tyr Arg Arg 
        435                 440                 445             


Thr Ser Gly Val His Asp Gly Ser Leu His Lys Gly Ala Trp Phe Leu 
    450                 455                 460                 


Val Cys Ser Gly Ala Leu Val Asn Glu Arg Thr Val Val Val Ala Ala 
465                 470                 475                 480 


His Cys Val Thr Asp Leu Gly Lys Val Thr Met Ile Lys Thr Ala Asp 
                485                 490                 495     


Leu Lys Val Val Leu Gly Lys Phe Tyr Arg Asp Asp Asp Arg Asp Glu 
            500                 505                 510         


Lys Thr Ile Gln Ser Leu Gln Ile Ser Ala Ile Ile Leu His Pro Asn 
        515                 520                 525             


Tyr Asp Pro Ile Leu Leu Asp Ala Asp Ile Ala Ile Leu Lys Leu Leu 
    530                 535                 540                 


Asp Lys Ala Arg Ile Ser Thr Arg Val Gln Pro Ile Cys Leu Ala Ala 
545                 550                 555                 560 


Ser Arg Asp Leu Ser Thr Ser Phe Gln Glu Ser His Ile Thr Val Ala 
                565                 570                 575     


Gly Trp Asn Val Leu Ala Asp Val Arg Ser Pro Gly Phe Lys Asn Asp 
            580                 585                 590         


Thr Leu Arg Ser Gly Val Val Ser Val Val Asp Ser Leu Leu Cys Glu 
        595                 600                 605             


Glu Gln His Glu Asp His Gly Ile Pro Val Ser Val Thr Asp Asn Met 
    610                 615                 620                 


Phe Cys Ala Ser Trp Glu Pro Thr Ala Pro Ser Asp Ile Cys Thr Ala 
625                 630                 635                 640 


Glu Thr Gly Gly Ile Ala Ala Val Ser Phe Pro Gly Arg Ala Ser Pro 
                645                 650                 655     


Glu Pro Arg Trp His Leu Met Gly Leu Val Ser Trp Ser Tyr Asp Lys 
            660                 665                 670         


Thr Cys Ser 
        675 


<210>  9978
<211>  680
<212>  PRT
<213>  Homo Sapiens

<400>  9978

Met Cys Arg Glu Cys Cys Glu Tyr Asp Gln Ile Glu Cys Val Cys Pro 
1               5                   10                  15      


Gly Lys Arg Glu Val Val Gly Tyr Thr Ile Pro Cys Cys Arg Asn Glu 
            20                  25                  30          


Glu Asn Glu Cys Asp Ser Cys Leu Ile His Pro Gly Cys Thr Ile Phe 
        35                  40                  45              


Glu Asn Cys Lys Ser Cys Arg Asn Gly Ser Trp Gly Gly Thr Leu Asp 
    50                  55                  60                  


Asp Phe Tyr Val Lys Gly Phe Tyr Cys Ala Glu Cys Arg Ala Gly Trp 
65                  70                  75                  80  


Tyr Gly Gly Asp Cys Met Arg Cys Gly Gln Val Leu Arg Ala Pro Lys 
                85                  90                  95      


Gly Gln Ile Leu Leu Glu Ser Tyr Pro Leu Asn Ala His Cys Glu Trp 
            100                 105                 110         


Thr Ile His Ala Lys Pro Gly Phe Val Ile Gln Leu Arg Phe Val Met 
        115                 120                 125             


Leu Ser Leu Glu Phe Asp Tyr Met Cys Gln Tyr Asp Tyr Val Glu Val 
    130                 135                 140                 


Arg Asp Gly Asp Asn Arg Asp Gly Gln Ile Ile Lys Arg Val Cys Gly 
145                 150                 155                 160 


Asn Glu Arg Pro Ala Pro Ile Gln Ser Ile Gly Ser Ser Leu His Val 
                165                 170                 175     


Leu Phe His Ser Asp Gly Ser Lys Asn Phe Asp Gly Phe His Ala Ile 
            180                 185                 190         


Tyr Glu Glu Ile Thr Ala Cys Ser Ser Ser Pro Cys Phe His Asp Gly 
        195                 200                 205             


Thr Cys Val Leu Asp Lys Ala Gly Ser Tyr Lys Cys Ala Cys Leu Ala 
    210                 215                 220                 


Gly Tyr Thr Gly Gln Arg Cys Glu Asn Leu Leu Glu Glu Arg Asn Cys 
225                 230                 235                 240 


Ser Asp Pro Gly Gly Pro Val Asn Gly Tyr Gln Lys Ile Thr Gly Gly 
                245                 250                 255     


Pro Gly Leu Ile Asn Gly Arg His Ala Lys Ile Gly Thr Val Val Ser 
            260                 265                 270         


Phe Phe Cys Asn Asn Ser Tyr Val Leu Ser Gly Asn Glu Lys Arg Thr 
        275                 280                 285             


Cys Gln Gln Asn Gly Glu Trp Ser Gly Lys Gln Pro Ile Cys Ile Lys 
    290                 295                 300                 


Ala Cys Arg Glu Pro Lys Ile Ser Asp Leu Val Arg Arg Arg Val Leu 
305                 310                 315                 320 


Pro Met Gln Val Gln Ser Arg Glu Thr Pro Leu His Gln Leu Tyr Ser 
                325                 330                 335     


Ala Ala Phe Ser Lys Gln Lys Leu Gln Ser Ala Pro Thr Lys Lys Pro 
            340                 345                 350         


Ala Leu Pro Phe Gly Asp Leu Pro Met Gly Tyr Gln His Leu His Thr 
        355                 360                 365             


Gln Leu Gln Tyr Glu Cys Ile Ser Pro Phe Tyr Arg Arg Leu Gly Ser 
    370                 375                 380                 


Ser Arg Arg Thr Cys Leu Arg Thr Gly Lys Trp Ser Gly Arg Ala Pro 
385                 390                 395                 400 


Ser Cys Ile Pro Ile Cys Gly Lys Ile Glu Asn Ile Thr Ala Pro Lys 
                405                 410                 415     


Thr Gln Gly Leu Arg Trp Pro Trp Gln Ala Ala Ile Tyr Arg Arg Thr 
            420                 425                 430         


Ser Gly Val His Asp Gly Ser Leu His Lys Gly Ala Trp Phe Leu Val 
        435                 440                 445             


Cys Ser Gly Ala Leu Val Asn Glu Arg Thr Val Val Val Ala Ala His 
    450                 455                 460                 


Cys Val Thr Asp Leu Gly Lys Val Thr Met Ile Lys Thr Ala Asp Leu 
465                 470                 475                 480 


Lys Val Val Leu Gly Lys Phe Tyr Arg Asp Asp Asp Arg Asp Glu Lys 
                485                 490                 495     


Thr Ile Gln Ser Leu Gln Ile Ser Ala Ile Ile Leu His Pro Asn Tyr 
            500                 505                 510         


Asp Pro Ile Leu Leu Asp Ala Asp Ile Ala Ile Leu Lys Leu Leu Asp 
        515                 520                 525             


Lys Ala Arg Ile Ser Thr Arg Val Gln Pro Ile Cys Leu Ala Ala Ser 
    530                 535                 540                 


Arg Asp Leu Ser Thr Ser Phe Gln Glu Ser His Ile Thr Val Ala Gly 
545                 550                 555                 560 


Trp Asn Val Leu Ala Asp Val Arg Ser Pro Gly Phe Lys Asn Asp Thr 
                565                 570                 575     


Leu Arg Ser Gly Val Val Ser Val Val Asp Ser Leu Leu Cys Glu Glu 
            580                 585                 590         


Gln His Glu Asp His Gly Ile Pro Val Ser Val Thr Asp Asn Met Phe 
        595                 600                 605             


Cys Ala Ser Trp Glu Pro Thr Ala Pro Ser Asp Ile Cys Thr Ala Glu 
    610                 615                 620                 


Thr Gly Gly Ile Ala Ala Val Ser Phe Pro Gly Arg Ala Ser Pro Glu 
625                 630                 635                 640 


Pro Arg Trp His Leu Met Gly Leu Val Ser Trp Ser Tyr Asp Lys Thr 
                645                 650                 655     


Cys Ser His Arg Leu Ser Thr Ala Phe Thr Lys Val Leu Pro Phe Lys 
            660                 665                 670         


Asp Trp Ile Glu Arg Asn Met Lys 
        675                 680 


<210>  9979
<211>  178
<212>  PRT
<213>  Homo Sapiens

<400>  9979

Met Glu Leu Gly Cys Trp Thr Gln Leu Gly Leu Thr Phe Leu Gln Leu 
1               5                   10                  15      


Leu Leu Ile Ser Ser Leu Pro Arg Glu Tyr Thr Val Ile Asn Glu Ala 
            20                  25                  30          


Cys Pro Gly Ala Glu Trp Asn Ile Met Cys Arg Glu Cys Cys Glu Tyr 
        35                  40                  45              


Asp Gln Ile Glu Cys Val Cys Pro Gly Lys Arg Glu Val Val Gly Tyr 
    50                  55                  60                  


Thr Ile Pro Cys Cys Arg Asn Glu Glu Asn Glu Cys Asp Ser Cys Leu 
65                  70                  75                  80  


Ile His Pro Gly Cys Thr Ile Phe Glu Asn Cys Lys Ser Cys Arg Asn 
                85                  90                  95      


Gly Ser Trp Gly Gly Thr Leu Asp Asp Phe Tyr Val Lys Gly Phe Tyr 
            100                 105                 110         


Cys Ala Glu Cys Arg Ala Gly Trp Tyr Gly Gly Asp Cys Met Pro Cys 
        115                 120                 125             


Ser Ser Ser Pro Cys Phe His Asp Gly Thr Cys Val Leu Asp Lys Ala 
    130                 135                 140                 


Gly Ser Tyr Lys Cys Ala Cys Leu Ala Gly Tyr Thr Gly Gln Arg Cys 
145                 150                 155                 160 


Glu Asn Leu Leu Glu Glu Arg Asn Cys Ser Asp Pro Gly Gly Pro Val 
                165                 170                 175     


Asn Gly 
        


<210>  9980
<211>  609
<212>  PRT
<213>  Homo Sapiens

<400>  9980

Met Glu Leu Gly Cys Trp Thr Gln Leu Gly Leu Thr Phe Leu Gln Leu 
1               5                   10                  15      


Leu Leu Ile Ser Ser Leu Pro Arg Glu Tyr Thr Val Ile Asn Glu Ala 
            20                  25                  30          


Cys Pro Gly Ala Glu Trp Asn Ile Met Cys Arg Glu Cys Cys Glu Tyr 
        35                  40                  45              


Asp Gln Ile Glu Cys Val Cys Pro Gly Lys Arg Glu Val Val Gly Tyr 
    50                  55                  60                  


Thr Ile Pro Cys Cys Arg Asn Glu Glu Asn Glu Cys Asp Ser Cys Leu 
65                  70                  75                  80  


Ile His Pro Gly Cys Thr Ile Phe Glu Asn Cys Lys Ser Cys Arg Asn 
                85                  90                  95      


Gly Ser Trp Gly Gly Thr Leu Asp Asp Phe Tyr Val Lys Gly Phe Tyr 
            100                 105                 110         


Cys Ala Glu Cys Arg Ala Gly Trp Tyr Gly Gly Asp Cys Met Pro Cys 
        115                 120                 125             


Ser Ser Ser Pro Cys Phe His Asp Gly Thr Cys Val Leu Asp Lys Ala 
    130                 135                 140                 


Gly Ser Tyr Lys Cys Ala Cys Leu Ala Gly Tyr Thr Gly Gln Arg Cys 
145                 150                 155                 160 


Glu Asn Leu Leu Glu Glu Arg Asn Cys Ser Asp Pro Gly Gly Pro Val 
                165                 170                 175     


Asn Gly Tyr Gln Lys Ile Thr Gly Gly Pro Gly Leu Ile Asn Gly Arg 
            180                 185                 190         


His Ala Lys Ile Gly Thr Val Val Ser Phe Phe Cys Asn Asn Ser Tyr 
        195                 200                 205             


Val Leu Ser Gly Asn Glu Lys Arg Thr Cys Gln Gln Asn Gly Glu Trp 
    210                 215                 220                 


Ser Gly Lys Gln Pro Ile Cys Ile Lys Ala Cys Arg Glu Pro Lys Ile 
225                 230                 235                 240 


Ser Asp Leu Val Arg Arg Arg Val Leu Pro Met Gln Val Gln Ser Arg 
                245                 250                 255     


Glu Thr Pro Leu His Gln Leu Tyr Ser Ala Ala Phe Ser Lys Gln Lys 
            260                 265                 270         


Leu Gln Ser Ala Pro Thr Lys Lys Pro Ala Leu Pro Phe Gly Asp Leu 
        275                 280                 285             


Pro Met Gly Tyr Gln His Leu His Thr Gln Leu Gln Tyr Glu Cys Ile 
    290                 295                 300                 


Ser Pro Phe Tyr Arg Arg Leu Gly Ser Ser Arg Arg Thr Cys Leu Arg 
305                 310                 315                 320 


Thr Gly Lys Trp Ser Gly Arg Ala Pro Ser Cys Ile Pro Ile Cys Gly 
                325                 330                 335     


Lys Ile Glu Asn Ile Thr Ala Pro Lys Thr Gln Gly Leu Arg Trp Pro 
            340                 345                 350         


Trp Gln Ala Ala Ile Tyr Arg Arg Thr Ser Gly Val His Asp Gly Ser 
        355                 360                 365             


Leu His Lys Gly Ala Trp Phe Leu Val Cys Ser Gly Ala Leu Val Asn 
    370                 375                 380                 


Glu Arg Thr Val Val Val Ala Ala His Cys Val Thr Asp Leu Gly Lys 
385                 390                 395                 400 


Val Thr Met Ile Lys Thr Ala Asp Leu Lys Val Val Leu Gly Lys Phe 
                405                 410                 415     


Tyr Arg Asp Asp Asp Arg Asp Glu Lys Thr Ile Gln Ser Leu Gln Ile 
            420                 425                 430         


Ser Ala Ile Ile Leu His Pro Asn Tyr Asp Pro Ile Leu Leu Asp Ala 
        435                 440                 445             


Asp Ile Ala Ile Leu Lys Leu Leu Asp Lys Ala Arg Ile Ser Thr Arg 
    450                 455                 460                 


Val Gln Pro Ile Cys Leu Ala Ala Ser Arg Asp Leu Ser Thr Ser Phe 
465                 470                 475                 480 


Gln Glu Ser His Ile Thr Val Ala Gly Trp Asn Val Leu Ala Asp Val 
                485                 490                 495     


Arg Ser Pro Gly Phe Lys Asn Asp Thr Leu Arg Ser Gly Val Val Ser 
            500                 505                 510         


Val Val Asp Ser Leu Leu Cys Glu Glu Gln His Glu Asp His Gly Ile 
        515                 520                 525             


Pro Val Ser Val Thr Asp Asn Met Phe Cys Ala Ser Trp Glu Pro Thr 
    530                 535                 540                 


Ala Pro Ser Asp Ile Cys Thr Ala Glu Thr Gly Gly Ile Ala Ala Val 
545                 550                 555                 560 


Ser Phe Pro Gly Arg Ala Ser Pro Glu Pro Arg Trp His Leu Met Gly 
                565                 570                 575     


Leu Val Ser Trp Ser Tyr Asp Lys Thr Cys Ser His Arg Leu Ser Thr 
            580                 585                 590         


Ala Phe Thr Lys Val Leu Pro Phe Lys Asp Trp Ile Glu Arg Asn Met 
        595                 600                 605             


Lys 
    


<210>  9981
<211>  737
<212>  PRT
<213>  Homo Sapiens

<400>  9981

Met Glu Leu Gly Cys Trp Thr Gln Leu Gly Leu Thr Phe Leu Gln Leu 
1               5                   10                  15      


Leu Leu Ile Ser Ser Leu Pro Arg Glu Tyr Thr Val Ile Asn Glu Ala 
            20                  25                  30          


Cys Pro Gly Ala Glu Trp Asn Ile Met Cys Arg Glu Cys Cys Glu Tyr 
        35                  40                  45              


Asp Gln Ile Glu Cys Val Cys Pro Gly Lys Arg Glu Val Val Gly Tyr 
    50                  55                  60                  


Thr Ile Pro Cys Cys Arg Asn Glu Glu Asn Glu Cys Asp Ser Cys Leu 
65                  70                  75                  80  


Ile His Pro Gly Cys Thr Ile Phe Glu Asn Cys Lys Ser Cys Arg Asn 
                85                  90                  95      


Gly Ser Trp Gly Gly Thr Leu Asp Asp Phe Tyr Val Lys Gly Phe Tyr 
            100                 105                 110         


Cys Ala Glu Cys Arg Ala Gly Trp Tyr Gly Gly Asp Cys Met Arg Cys 
        115                 120                 125             


Gly Gln Val Leu Arg Ala Pro Lys Gly Gln Ile Leu Leu Glu Ser Tyr 
    130                 135                 140                 


Pro Leu Asn Ala His Cys Glu Trp Thr Ile His Ala Lys Pro Gly Phe 
145                 150                 155                 160 


Val Ile Gln Leu Arg Phe Val Met Leu Ser Leu Glu Phe Asp Tyr Met 
                165                 170                 175     


Cys Gln Tyr Asp Tyr Val Glu Val Arg Asp Gly Asp Asn Arg Asp Gly 
            180                 185                 190         


Gln Ile Ile Lys Arg Val Cys Gly Asn Glu Arg Pro Ala Pro Ile Gln 
        195                 200                 205             


Ser Ile Gly Ser Ser Leu His Val Leu Phe His Ser Asp Gly Ser Lys 
    210                 215                 220                 


Asn Phe Asp Gly Phe His Ala Ile Tyr Glu Glu Ile Thr Ala Cys Ser 
225                 230                 235                 240 


Ser Ser Pro Cys Phe His Asp Gly Thr Cys Val Leu Asp Lys Ala Gly 
                245                 250                 255     


Ser Tyr Lys Cys Ala Cys Leu Ala Gly Tyr Thr Gly Gln Arg Cys Glu 
            260                 265                 270         


Asn Leu Leu Glu Ala Gly Lys Ser Lys Ile Lys Ala Ser Glu Asp Ser 
        275                 280                 285             


Leu Ser Val Leu Glu Glu Arg Asn Cys Ser Asp Pro Gly Gly Pro Val 
    290                 295                 300                 


Asn Gly Tyr Gln Lys Ile Thr Gly Gly Pro Gly Leu Ile Asn Gly Arg 
305                 310                 315                 320 


His Ala Lys Ile Gly Thr Val Val Ser Phe Phe Cys Asn Asn Ser Tyr 
                325                 330                 335     


Val Leu Ser Gly Asn Glu Lys Arg Thr Cys Gln Gln Asn Gly Glu Trp 
            340                 345                 350         


Ser Gly Lys Gln Pro Ile Cys Ile Lys Ala Cys Arg Glu Pro Lys Ile 
        355                 360                 365             


Ser Asp Leu Val Arg Arg Arg Val Leu Pro Met Gln Val Gln Ser Arg 
    370                 375                 380                 


Glu Thr Pro Leu His Gln Leu Tyr Ser Ala Ala Phe Ser Lys Gln Lys 
385                 390                 395                 400 


Leu Gln Ser Ala Pro Thr Lys Lys Pro Ala Leu Pro Phe Gly Asp Leu 
                405                 410                 415     


Pro Met Gly Tyr Gln His Leu His Thr Gln Leu Gln Tyr Glu Cys Ile 
            420                 425                 430         


Ser Pro Phe Tyr Arg Arg Leu Gly Ser Ser Arg Arg Thr Cys Leu Arg 
        435                 440                 445             


Thr Gly Lys Trp Ser Gly Arg Ala Pro Ser Cys Ile Pro Ile Cys Gly 
    450                 455                 460                 


Lys Ile Glu Asn Ile Thr Ala Pro Lys Thr Gln Gly Leu Arg Trp Pro 
465                 470                 475                 480 


Trp Gln Ala Ala Ile Tyr Arg Arg Thr Ser Gly Val His Asp Gly Ser 
                485                 490                 495     


Leu His Lys Gly Ala Trp Phe Leu Val Cys Ser Gly Ala Leu Val Asn 
            500                 505                 510         


Glu Arg Thr Val Val Val Ala Ala His Cys Val Thr Asp Leu Gly Lys 
        515                 520                 525             


Val Thr Met Ile Lys Thr Ala Asp Leu Lys Val Val Leu Gly Lys Phe 
    530                 535                 540                 


Tyr Arg Asp Asp Asp Arg Asp Glu Lys Thr Ile Gln Ser Leu Gln Ile 
545                 550                 555                 560 


Ser Ala Ile Ile Leu His Pro Asn Tyr Asp Pro Ile Leu Leu Asp Ala 
                565                 570                 575     


Asp Ile Ala Ile Leu Lys Leu Leu Asp Lys Ala Arg Ile Ser Thr Arg 
            580                 585                 590         


Val Gln Pro Ile Cys Leu Ala Ala Ser Arg Asp Leu Ser Thr Ser Phe 
        595                 600                 605             


Gln Glu Ser His Ile Thr Val Ala Gly Trp Asn Val Leu Ala Asp Val 
    610                 615                 620                 


Arg Ser Pro Gly Phe Lys Asn Asp Thr Leu Arg Ser Gly Val Val Ser 
625                 630                 635                 640 


Val Val Asp Ser Leu Leu Cys Glu Glu Gln His Glu Asp His Gly Ile 
                645                 650                 655     


Pro Val Ser Val Thr Asp Asn Met Phe Cys Ala Ser Trp Glu Pro Thr 
            660                 665                 670         


Ala Pro Ser Asp Ile Cys Thr Ala Glu Thr Gly Gly Ile Ala Ala Val 
        675                 680                 685             


Ser Phe Pro Gly Arg Ala Ser Pro Glu Pro Arg Trp His Leu Met Gly 
    690                 695                 700                 


Leu Val Ser Trp Ser Tyr Asp Lys Thr Cys Ser His Arg Leu Ser Thr 
705                 710                 715                 720 


Ala Phe Thr Lys Val Leu Pro Phe Lys Asp Trp Ile Glu Arg Asn Met 
                725                 730                 735     


Lys 
    


<210>  9982
<211>  720
<212>  PRT
<213>  Homo Sapiens

<400>  9982

Met Glu Leu Gly Cys Trp Thr Gln Leu Gly Leu Thr Phe Leu Gln Leu 
1               5                   10                  15      


Leu Leu Ile Ser Ser Leu Pro Arg Glu Tyr Thr Val Ile Asn Glu Ala 
            20                  25                  30          


Cys Pro Gly Ala Glu Trp Asn Ile Met Cys Arg Glu Cys Cys Glu Tyr 
        35                  40                  45              


Asp Gln Ile Glu Cys Val Cys Pro Gly Lys Arg Glu Val Val Gly Tyr 
    50                  55                  60                  


Thr Ile Pro Cys Cys Arg Asn Glu Glu Asn Glu Cys Asp Ser Cys Leu 
65                  70                  75                  80  


Ile His Pro Gly Cys Thr Ile Phe Glu Asn Cys Lys Ser Cys Arg Asn 
                85                  90                  95      


Gly Ser Trp Gly Gly Thr Leu Asp Asp Phe Tyr Val Lys Gly Phe Tyr 
            100                 105                 110         


Cys Ala Glu Cys Arg Ala Gly Trp Tyr Gly Gly Asp Cys Met Arg Cys 
        115                 120                 125             


Gly Gln Val Leu Arg Ala Pro Lys Gly Gln Ile Leu Leu Glu Ser Tyr 
    130                 135                 140                 


Pro Leu Asn Ala His Cys Glu Trp Thr Ile His Ala Lys Pro Gly Phe 
145                 150                 155                 160 


Val Ile Gln Leu Arg Phe Val Met Leu Ser Leu Glu Phe Asp Tyr Met 
                165                 170                 175     


Cys Gln Tyr Asp Tyr Val Glu Val Arg Asp Gly Asp Asn Arg Asp Gly 
            180                 185                 190         


Gln Ile Ile Lys Arg Val Cys Gly Asn Glu Arg Pro Ala Pro Ile Gln 
        195                 200                 205             


Ser Ile Gly Ser Ser Leu His Val Leu Phe His Ser Asp Gly Ser Lys 
    210                 215                 220                 


Asn Phe Asp Gly Phe His Ala Ile Tyr Glu Glu Ile Thr Ala Cys Ser 
225                 230                 235                 240 


Ser Ser Pro Cys Phe His Asp Gly Thr Cys Val Leu Asp Lys Ala Gly 
                245                 250                 255     


Ser Tyr Lys Cys Ala Cys Leu Ala Gly Tyr Thr Gly Gln Arg Cys Glu 
            260                 265                 270         


Asn Leu Leu Glu Glu Arg Asn Cys Ser Asp Pro Gly Gly Pro Val Asn 
        275                 280                 285             


Gly Tyr Gln Lys Ile Thr Gly Gly Pro Gly Leu Ile Asn Gly Arg His 
    290                 295                 300                 


Ala Lys Ile Gly Thr Val Val Ser Phe Phe Cys Asn Asn Ser Tyr Val 
305                 310                 315                 320 


Leu Ser Gly Asn Glu Lys Arg Thr Cys Gln Gln Asn Gly Glu Trp Ser 
                325                 330                 335     


Gly Lys Gln Pro Ile Cys Ile Lys Ala Cys Arg Glu Pro Lys Ile Ser 
            340                 345                 350         


Asp Leu Val Arg Arg Arg Val Leu Pro Met Gln Val Gln Ser Arg Glu 
        355                 360                 365             


Thr Pro Leu His Gln Leu Tyr Ser Ala Ala Phe Ser Lys Gln Lys Leu 
    370                 375                 380                 


Gln Ser Ala Pro Thr Lys Lys Pro Ala Leu Pro Phe Gly Asp Leu Pro 
385                 390                 395                 400 


Met Gly Tyr Gln His Leu His Thr Gln Leu Gln Tyr Glu Cys Ile Ser 
                405                 410                 415     


Pro Phe Tyr Arg Arg Leu Gly Ser Ser Arg Arg Thr Cys Leu Arg Thr 
            420                 425                 430         


Gly Lys Trp Ser Gly Arg Ala Pro Ser Cys Ile Pro Ile Cys Gly Lys 
        435                 440                 445             


Ile Glu Asn Ile Thr Ala Pro Lys Thr Gln Gly Leu Arg Trp Pro Trp 
    450                 455                 460                 


Gln Ala Ala Ile Tyr Arg Arg Thr Ser Gly Val His Asp Gly Ser Leu 
465                 470                 475                 480 


His Lys Gly Ala Trp Phe Leu Val Cys Ser Gly Ala Leu Val Asn Glu 
                485                 490                 495     


Arg Thr Val Val Val Ala Ala His Cys Val Thr Asp Leu Gly Lys Val 
            500                 505                 510         


Thr Met Ile Lys Thr Ala Asp Leu Lys Val Val Leu Gly Lys Phe Tyr 
        515                 520                 525             


Arg Asp Asp Asp Arg Asp Glu Lys Thr Ile Gln Ser Leu Gln Ile Ser 
    530                 535                 540                 


Ala Ile Ile Leu His Pro Asn Tyr Asp Pro Ile Leu Leu Asp Ala Asp 
545                 550                 555                 560 


Ile Ala Ile Leu Lys Leu Leu Asp Lys Ala Arg Ile Ser Thr Arg Val 
                565                 570                 575     


Gln Pro Ile Cys Leu Ala Ala Ser Arg Asp Leu Ser Thr Ser Phe Gln 
            580                 585                 590         


Glu Ser His Ile Thr Val Ala Gly Trp Asn Val Leu Ala Asp Val Arg 
        595                 600                 605             


Ser Pro Gly Phe Lys Asn Asp Thr Leu Arg Ser Gly Val Val Ser Val 
    610                 615                 620                 


Val Asp Ser Leu Leu Cys Glu Glu Gln His Glu Asp His Gly Ile Pro 
625                 630                 635                 640 


Val Ser Val Thr Asp Asn Met Phe Cys Ala Ser Trp Glu Pro Thr Ala 
                645                 650                 655     


Pro Ser Asp Ile Cys Thr Ala Glu Thr Gly Gly Ile Ala Ala Val Ser 
            660                 665                 670         


Phe Pro Gly Arg Ala Ser Pro Glu Pro Arg Trp His Leu Met Gly Leu 
        675                 680                 685             


Val Ser Trp Ser Tyr Asp Lys Thr Cys Ser His Arg Leu Ser Thr Ala 
    690                 695                 700                 


Phe Thr Lys Val Leu Pro Phe Lys Asp Trp Ile Glu Arg Asn Met Lys 
705                 710                 715                 720 


<210>  9983
<211>  416
<212>  PRT
<213>  Homo Sapiens

<400>  9983

Met Leu Lys Leu Ala Pro Trp Cys Leu Ser Phe Val Thr Thr Pro Met 
1               5                   10                  15      


Phe Leu Val Ala Met Arg Lys Glu Leu Ala Ser Arg Met Glu Trp Ser 
            20                  25                  30          


Gly Lys Gln Pro Ile Cys Ile Lys Ala Cys Arg Glu Pro Lys Ile Ser 
        35                  40                  45              


Asp Leu Val Arg Arg Arg Val Leu Pro Met Gln Val Gln Ser Arg Glu 
    50                  55                  60                  


Thr Pro Leu His Gln Leu Tyr Ser Ala Ala Phe Ser Lys Gln Lys Leu 
65                  70                  75                  80  


Gln Ser Ala Pro Thr Lys Lys Pro Ala Leu Pro Phe Gly Asp Leu Pro 
                85                  90                  95      


Met Gly Tyr Gln His Leu His Thr Gln Leu Gln Tyr Glu Cys Ile Ser 
            100                 105                 110         


Pro Phe Tyr Arg Arg Leu Gly Ser Ser Arg Arg Thr Cys Leu Arg Thr 
        115                 120                 125             


Gly Lys Trp Ser Gly Arg Ala Pro Ser Cys Ile Pro Ile Cys Gly Lys 
    130                 135                 140                 


Ile Glu Asn Ile Thr Ala Pro Lys Thr Gln Gly Leu Arg Trp Pro Trp 
145                 150                 155                 160 


Gln Ala Ala Ile Tyr Arg Arg Thr Ser Gly Val His Asp Gly Ser Leu 
                165                 170                 175     


His Lys Gly Ala Trp Phe Leu Val Cys Ser Gly Ala Leu Val Asn Glu 
            180                 185                 190         


Arg Thr Val Val Val Ala Ala His Cys Val Thr Asp Leu Gly Lys Val 
        195                 200                 205             


Thr Met Ile Lys Thr Ala Asp Leu Lys Val Val Leu Gly Lys Phe Tyr 
    210                 215                 220                 


Arg Asp Asp Asp Arg Asp Glu Lys Thr Ile Gln Ser Leu Gln Ile Ser 
225                 230                 235                 240 


Ala Ile Ile Leu His Pro Asn Tyr Asp Pro Ile Leu Leu Asp Ala Asp 
                245                 250                 255     


Ile Ala Ile Leu Lys Leu Leu Asp Lys Ala Arg Ile Ser Thr Arg Val 
            260                 265                 270         


Gln Pro Ile Cys Leu Ala Ala Ser Arg Asp Leu Ser Thr Ser Phe Gln 
        275                 280                 285             


Glu Ser His Ile Thr Val Ala Gly Trp Asn Val Leu Ala Asp Val Arg 
    290                 295                 300                 


Ser Pro Gly Phe Lys Asn Asp Thr Leu Arg Ser Gly Val Val Ser Val 
305                 310                 315                 320 


Val Asp Ser Leu Leu Cys Glu Glu Gln His Glu Asp His Gly Ile Pro 
                325                 330                 335     


Val Ser Val Thr Asp Asn Met Phe Cys Ala Ser Trp Glu Pro Thr Ala 
            340                 345                 350         


Pro Ser Asp Ile Cys Thr Ala Glu Thr Gly Gly Ile Ala Ala Val Ser 
        355                 360                 365             


Phe Pro Gly Arg Ala Ser Pro Glu Pro Arg Trp His Leu Met Gly Leu 
    370                 375                 380                 


Val Ser Trp Ser Tyr Asp Lys Thr Cys Ser His Arg Leu Ser Thr Ala 
385                 390                 395                 400 


Phe Thr Lys Val Leu Pro Phe Lys Asp Trp Ile Glu Arg Asn Met Lys 
                405                 410                 415     


<210>  9984
<211>  1251
<212>  PRT
<213>  Homo Sapiens

<400>  9984

Met Arg Leu Leu Leu Leu Val Pro Leu Leu Leu Ala Pro Ala Pro Gly 
1               5                   10                  15      


Ser Ser Ala Pro Lys Val Arg Arg Gln Ser Asp Thr Trp Gly Pro Trp 
            20                  25                  30          


Ser Gln Trp Ser Pro Cys Ser Arg Thr Cys Gly Gly Gly Val Ser Phe 
        35                  40                  45              


Arg Glu Arg Pro Cys Tyr Ser Gln Arg Arg Asp Gly Gly Ser Ser Cys 
    50                  55                  60                  


Val Gly Pro Ala Arg Ser His Arg Ser Cys Arg Thr Glu Ser Cys Pro 
65                  70                  75                  80  


Asp Gly Ala Arg Asp Phe Arg Ala Glu Gln Cys Ala Glu Phe Asp Gly 
                85                  90                  95      


Ala Glu Phe Gln Gly Arg Arg Tyr Arg Trp Leu Pro Tyr Tyr Ser Ala 
            100                 105                 110         


Pro Asn Lys Cys Glu Leu Asn Cys Ile Pro Lys Gly Glu Asn Phe Tyr 
        115                 120                 125             


Tyr Lys His Arg Glu Ala Val Val Asp Gly Thr Pro Cys Glu Pro Gly 
    130                 135                 140                 


Lys Arg Asp Val Cys Val Asp Gly Ser Cys Arg Val Val Gly Cys Asp 
145                 150                 155                 160 


His Glu Leu Asp Ser Ser Lys Gln Glu Asp Lys Cys Leu Arg Cys Gly 
                165                 170                 175     


Gly Asp Gly Thr Thr Cys Tyr Pro Val Ala Gly Thr Phe Asp Ala Asn 
            180                 185                 190         


Asp Leu Ser Arg Ala Val Lys Asn Val Arg Gly Glu Tyr Tyr Leu Asn 
        195                 200                 205             


Gly His Trp Thr Ile Glu Ala Ala Arg Ala Leu Pro Ala Ala Ser Thr 
    210                 215                 220                 


Ile Leu His Tyr Glu Arg Gly Ala Glu Gly Asp Leu Ala Pro Glu Arg 
225                 230                 235                 240 


Leu His Ala Arg Gly Pro Thr Ser Glu Pro Leu Val Ile Glu Leu Ile 
                245                 250                 255     


Ser Gln Glu Pro Asn Pro Gly Val His Tyr Glu Tyr His Leu Pro Leu 
            260                 265                 270         


Arg Arg Pro Ser Pro Gly Phe Ser Trp Ser His Gly Ser Trp Ser Asp 
        275                 280                 285             


Cys Ser Ala Glu Cys Gly Gly Gly His Gln Ser Arg Leu Val Phe Cys 
    290                 295                 300                 


Thr Ile Asp His Glu Ala Tyr Pro Asp His Met Cys Gln Arg Gln Pro 
305                 310                 315                 320 


Arg Pro Ala Asp Arg Arg Ser Cys Asn Leu His Pro Cys Pro Glu Thr 
                325                 330                 335     


Lys Arg Trp Lys Ala Gly Pro Trp Ala Pro Cys Ser Ala Ser Cys Gly 
            340                 345                 350         


Gly Gly Ser Gln Ser Arg Ser Val Tyr Cys Ile Ser Ser Asp Gly Ala 
        355                 360                 365             


Gly Ile Gln Glu Ala Val Glu Glu Ala Glu Cys Ala Gly Leu Pro Gly 
    370                 375                 380                 


Lys Pro Pro Ala Ile Gln Ala Cys Asn Leu Gln Arg Cys Ala Ala Trp 
385                 390                 395                 400 


Ser Pro Glu Pro Trp Gly Glu Cys Ser Val Ser Cys Gly Val Gly Val 
                405                 410                 415     


Arg Lys Arg Ser Val Thr Cys Arg Gly Glu Arg Gly Ser Leu Leu His 
            420                 425                 430         


Thr Ala Ala Cys Ser Leu Glu Asp Arg Pro Pro Leu Thr Glu Pro Cys 
        435                 440                 445             


Val His Glu Asp Cys Pro Leu Leu Ser Asp Gln Ala Trp His Val Gly 
    450                 455                 460                 


Thr Trp Gly Leu Cys Ser Lys Ser Cys Ser Ser Gly Thr Arg Arg Arg 
465                 470                 475                 480 


Gln Val Ile Cys Ala Ile Gly Pro Pro Ser His Cys Gly Ser Leu Gln 
                485                 490                 495     


His Ser Lys Pro Val Asp Val Glu Pro Cys Asn Thr Gln Pro Cys His 
            500                 505                 510         


Leu Pro Gln Glu Val Pro Ser Met Gln Asp Val His Thr Pro Ala Ser 
        515                 520                 525             


Asn Pro Trp Met Pro Leu Gly Pro Gln Glu Ser Pro Ala Ser Asp Ser 
    530                 535                 540                 


Arg Gly Gln Trp Trp Ala Ala Gln Glu His Pro Ser Ala Arg Gly Asp 
545                 550                 555                 560 


His Arg Gly Glu Arg Gly Asp Pro Arg Gly Asp Gln Gly Thr His Leu 
                565                 570                 575     


Ser Ala Leu Gly Pro Ala Pro Ser Leu Gln Gln Pro Pro Tyr Gln Gln 
            580                 585                 590         


Pro Leu Arg Ser Gly Ser Gly Pro His Asp Cys Arg His Ser Pro His 
        595                 600                 605             


Gly Cys Cys Pro Asp Gly His Thr Ala Ser Leu Gly Pro Gln Trp Gln 
    610                 615                 620                 


Gly Cys Pro Gly Ala Pro Cys Gln Gln Ser Arg Tyr Gly Cys Cys Pro 
625                 630                 635                 640 


Asp Arg Val Ser Val Ala Glu Gly Pro His His Ala Gly Cys Thr Lys 
                645                 650                 655     


Ser Tyr Gly Gly Asp Ser Thr Gly Gly Met Pro Arg Ser Arg Ala Val 
            660                 665                 670         


Ala Ser Thr Val His Asn Thr His Gln Pro Gln Ala Gln Gln Asn Glu 
        675                 680                 685             


Pro Ser Glu Cys Arg Gly Ser Gln Phe Gly Cys Cys Tyr Asp Asn Val 
    690                 695                 700                 


Ala Thr Ala Ala Gly Pro Leu Gly Glu Gly Cys Val Gly Gln Pro Ser 
705                 710                 715                 720 


His Ala Tyr Pro Val Arg Cys Leu Leu Pro Ser Ala His Gly Ser Cys 
                725                 730                 735     


Ala Asp Trp Ala Ala Arg Trp Tyr Phe Val Ala Ser Val Gly Gln Cys 
            740                 745                 750         


Asn Arg Phe Trp Tyr Gly Gly Cys His Gly Asn Ala Asn Asn Phe Ala 
        755                 760                 765             


Ser Glu Gln Glu Cys Met Ser Ser Cys Gln Gly Ser Leu His Gly Pro 
    770                 775                 780                 


Arg Arg Pro Gln Pro Gly Ala Ser Gly Arg Ser Thr His Thr Asp Gly 
785                 790                 795                 800 


Gly Gly Ser Ser Pro Ala Gly Glu Gln Glu Pro Ser Gln His Arg Thr 
                805                 810                 815     


Gly Ala Ala Val Gln Arg Lys Pro Trp Pro Ser Gly Gly Leu Trp Arg 
            820                 825                 830         


Gln Asp Gln Gln Pro Gly Pro Gly Glu Ala Pro His Thr Gln Ala Phe 
        835                 840                 845             


Gly Glu Trp Pro Trp Gly Gln Glu Leu Gly Ser Arg Ala Pro Gly Leu 
    850                 855                 860                 


Gly Gly Asp Ala Gly Ser Pro Ala Pro Pro Phe His Ser Ser Ser Tyr 
865                 870                 875                 880 


Arg Ile Ser Leu Ala Gly Val Glu Pro Ser Leu Val Gln Ala Ala Leu 
                885                 890                 895     


Gly Gln Leu Val Arg Leu Ser Cys Ser Asp Asp Thr Ala Pro Glu Ser 
            900                 905                 910         


Gln Ala Ala Trp Gln Lys Asp Gly Gln Pro Ile Ser Ser Asp Arg His 
        915                 920                 925             


Arg Leu Gln Phe Asp Gly Ser Leu Ile Ile His Pro Leu Gln Ala Glu 
    930                 935                 940                 


Asp Ala Gly Thr Tyr Ser Cys Gly Ser Thr Arg Pro Gly Arg Asp Ser 
945                 950                 955                 960 


Gln Lys Ile Gln Leu Arg Ile Ile Gly Gly Asp Met Ala Val Leu Ser 
                965                 970                 975     


Glu Ala Glu Leu Ser Arg Phe Pro Gln Pro Arg Asp Pro Ala Gln Asp 
            980                 985                 990         


Phe Gly Gln Ala Gly Ala Ala Gly  Pro Leu Gly Ala Ile  Pro Ser Ser 
        995                 1000                 1005             


His Pro  Gln Pro Ala Asn Arg  Leu Arg Leu Asp Gln  Asn Gln Pro 
    1010                 1015                 1020             


Arg Val  Val Asp Ala Ser Pro  Gly Gln Arg Ile Arg  Met Thr Cys 
    1025                 1030                 1035             


Arg Ala  Glu Gly Phe Pro Pro  Pro Ala Ile Glu Trp  Gln Arg Asp 
    1040                 1045                 1050             


Gly Gln  Pro Val Ser Ser Pro  Arg His Gln Leu Gln  Pro Asp Gly 
    1055                 1060                 1065             


Ser Leu  Val Ile Ser Arg Val  Ala Val Glu Asp Gly  Gly Phe Tyr 
    1070                 1075                 1080             


Thr Cys  Val Ala Phe Asn Gly  Gln Asp Arg Asp Gln  Arg Trp Val 
    1085                 1090                 1095             


Gln Leu  Arg Val Leu Gly Glu  Leu Thr Ile Ser Gly  Leu Pro Pro 
    1100                 1105                 1110             


Thr Val  Thr Val Pro Glu Gly  Asp Thr Ala Arg Leu  Leu Cys Val 
    1115                 1120                 1125             


Val Ala  Gly Glu Ser Val Asn  Ile Arg Trp Ser Arg  Asn Gly Leu 
    1130                 1135                 1140             


Pro Val  Gln Ala Asp Gly His  Arg Val His Gln Ser  Pro Asp Gly 
    1145                 1150                 1155             


Thr Leu  Leu Ile Tyr Asn Leu  Arg Ala Arg Asp Glu  Gly Ser Tyr 
    1160                 1165                 1170             


Thr Cys  Ser Ala Tyr Gln Gly  Ser Gln Ala Val Ser  Arg Ser Thr 
    1175                 1180                 1185             


Glu Val  Lys Val Val Ser Pro  Ala Pro Thr Ala Gln  Pro Arg Asp 
    1190                 1195                 1200             


Pro Gly  Arg Asp Cys Val Asp  Gln Pro Glu Leu Ala  Asn Cys Asp 
    1205                 1210                 1215             


Leu Ile  Leu Gln Ala Gln Leu  Cys Gly Asn Glu Tyr  Tyr Ser Ser 
    1220                 1225                 1230             


Phe Cys  Cys Ala Ser Cys Ser  Arg Phe Gln Pro His  Ala Gln Pro 
    1235                 1240                 1245             


Ile Trp  Gln 
    1250     


<210>  9985
<211>  929
<212>  PRT
<213>  Homo Sapiens

<400>  9985

Met Arg Leu Leu Leu Leu Val Pro Leu Leu Leu Ala Pro Ala Pro Gly 
1               5                   10                  15      


Ser Ser Ala Pro Lys Val Arg Arg Gln Ser Asp Thr Trp Gly Pro Trp 
            20                  25                  30          


Ser Gln Trp Ser Pro Cys Ser Arg Thr Cys Gly Gly Gly Val Ser Phe 
        35                  40                  45              


Arg Glu Arg Pro Cys Tyr Ser Gln Arg Arg Asp Gly Gly Ser Ser Cys 
    50                  55                  60                  


Val Gly Pro Ala Arg Ser His Arg Ser Cys Arg Thr Glu Ser Cys Pro 
65                  70                  75                  80  


Asp Gly Ala Arg Asp Phe Arg Ala Glu Gln Cys Ala Glu Phe Asp Gly 
                85                  90                  95      


Ala Glu Phe Gln Gly Arg Arg Tyr Arg Trp Leu Pro Tyr Tyr Ser Ala 
            100                 105                 110         


Pro Asn Lys Cys Glu Leu Asn Cys Ile Pro Lys Gly Glu Asn Phe Tyr 
        115                 120                 125             


Tyr Lys His Arg Glu Ala Val Val Asp Gly Thr Pro Cys Glu Pro Gly 
    130                 135                 140                 


Lys Arg Asp Val Cys Val Asp Gly Ser Cys Arg Val Val Gly Cys Asp 
145                 150                 155                 160 


His Glu Leu Asp Ser Ser Lys Gln Glu Asp Lys Cys Leu Arg Cys Gly 
                165                 170                 175     


Gly Asp Gly Thr Thr Cys Tyr Pro Val Ala Gly Thr Phe Asp Ala Asn 
            180                 185                 190         


Asp Leu Ser Arg Ala Val Lys Asn Val Arg Gly Glu Tyr Tyr Leu Asn 
        195                 200                 205             


Gly His Trp Thr Ile Glu Ala Ala Arg Ala Leu Pro Ala Ala Ser Thr 
    210                 215                 220                 


Ile Leu His Tyr Glu Arg Gly Ala Glu Gly Asp Leu Ala Pro Glu Arg 
225                 230                 235                 240 


Leu His Ala Arg Gly Pro Thr Ser Glu Pro Leu Val Ile Glu Leu Ile 
                245                 250                 255     


Ser Gln Glu Pro Asn Pro Gly Val His Tyr Glu Tyr His Leu Pro Leu 
            260                 265                 270         


Arg Arg Pro Ser Pro Gly Phe Ser Trp Ser His Gly Ser Trp Ser Asp 
        275                 280                 285             


Cys Ser Ala Glu Cys Gly Gly Gly His Gln Ser Arg Leu Val Phe Cys 
    290                 295                 300                 


Thr Ile Asp His Glu Ala Tyr Pro Asp His Met Cys Gln Arg Gln Pro 
305                 310                 315                 320 


Arg Pro Ala Asp Arg Arg Ser Cys Asn Leu His Pro Cys Pro Glu Thr 
                325                 330                 335     


Lys Arg Trp Lys Ala Gly Pro Trp Ala Pro Cys Ser Ala Ser Cys Gly 
            340                 345                 350         


Gly Gly Ser Gln Ser Arg Ser Val Tyr Cys Ile Ser Ser Asp Gly Ala 
        355                 360                 365             


Gly Ile Gln Glu Ala Val Glu Glu Ala Glu Cys Ala Gly Leu Pro Gly 
    370                 375                 380                 


Lys Pro Pro Ala Ile Gln Ala Cys Asn Leu Gln Arg Cys Ala Ala Trp 
385                 390                 395                 400 


Ser Pro Glu Pro Trp Gly Glu Cys Ser Val Ser Cys Gly Val Gly Val 
                405                 410                 415     


Arg Lys Arg Ser Val Thr Cys Arg Gly Glu Arg Gly Ser Leu Leu His 
            420                 425                 430         


Thr Ala Ala Cys Ser Leu Glu Asp Arg Pro Pro Leu Thr Glu Pro Cys 
        435                 440                 445             


Val His Glu Asp Cys Pro Leu Leu Ser Asp Gln Ala Trp His Val Gly 
    450                 455                 460                 


Thr Trp Gly Leu Cys Ser Lys Ser Cys Ser Ser Gly Thr Arg Arg Arg 
465                 470                 475                 480 


Gln Val Ile Cys Ala Ile Gly Pro Pro Ser His Cys Gly Ser Leu Gln 
                485                 490                 495     


His Ser Lys Pro Val Asp Val Glu Pro Cys Asn Thr Gln Pro Cys His 
            500                 505                 510         


Leu Pro Gln Glu Val Pro Ser Met Gln Asp Val His Thr Pro Ala Ser 
        515                 520                 525             


Asn Pro Trp Met Pro Leu Gly Pro Gln Glu Ser Pro Ala Ser Asp Ser 
    530                 535                 540                 


Arg Gly Gln Trp Trp Ala Ala Gln Glu His Pro Ser Ala Arg Gly Asp 
545                 550                 555                 560 


His Arg Gly Glu Arg Gly Asp Pro Arg Gly Asp Gln Gly Thr His Leu 
                565                 570                 575     


Ser Ala Leu Gly Pro Ala Pro Ser Leu Gln Gln Pro Pro Tyr Gln Gln 
            580                 585                 590         


Pro Leu Arg Ser Gly Ser Gly Pro His Asp Cys Arg His Ser Pro His 
        595                 600                 605             


Gly Cys Cys Pro Asp Gly His Thr Ala Ser Leu Gly Pro Gln Trp Gln 
    610                 615                 620                 


Gly Cys Pro Gly Ala Pro Cys Gln Gln Ser Arg Tyr Gly Cys Cys Pro 
625                 630                 635                 640 


Asp Arg Val Ser Val Ala Glu Gly Pro His His Ala Gly Cys Thr Lys 
                645                 650                 655     


Ser Tyr Gly Gly Asp Ser Thr Gly Gly Met Pro Arg Ser Arg Ala Val 
            660                 665                 670         


Ala Ser Thr Val His Asn Thr His Gln Pro Gln Ala Gln Gln Asn Glu 
        675                 680                 685             


Pro Ser Glu Cys Arg Gly Ser Gln Phe Gly Cys Cys Tyr Asp Asn Val 
    690                 695                 700                 


Ala Thr Ala Ala Gly Pro Leu Gly Glu Gly Cys Val Gly Gln Pro Ser 
705                 710                 715                 720 


His Ala Tyr Pro Val Arg Cys Leu Leu Pro Ser Ala His Gly Ser Cys 
                725                 730                 735     


Ala Asp Trp Ala Ala Arg Trp Tyr Phe Val Ala Ser Val Gly Gln Cys 
            740                 745                 750         


Asn Arg Phe Trp Tyr Gly Gly Cys His Gly Asn Ala Asn Asn Phe Ala 
        755                 760                 765             


Ser Glu Gln Glu Cys Met Ser Ser Cys Gln Gly Ser Leu His Gly Pro 
    770                 775                 780                 


Arg Arg Pro Gln Pro Gly Ala Ser Gly Arg Ser Thr His Thr Asp Gly 
785                 790                 795                 800 


Gly Gly Ser Ser Pro Ala Gly Glu Gln Glu Pro Ser Gln His Arg Thr 
                805                 810                 815     


Gly Ala Ala Val Gln Arg Lys Pro Trp Pro Ser Gly Gly Leu Trp Arg 
            820                 825                 830         


Gln Asp Gln Gln Pro Gly Pro Gly Glu Ala Pro His Thr Gln Ala Phe 
        835                 840                 845             


Gly Glu Trp Pro Trp Gly Gln Glu Leu Gly Ser Arg Ala Pro Gly Leu 
    850                 855                 860                 


Gly Gly Asp Ala Gly Ser Pro Ala Pro Pro Phe His Ser Ser Ser Tyr 
865                 870                 875                 880 


Arg Ile Ser Leu Ala Gly Val Glu Pro Ser Leu Val Gln Ala Ala Leu 
                885                 890                 895     


Gly Gln Leu Val Arg Leu Ser Cys Ser Asp Asp Thr Ala Pro Glu Ser 
            900                 905                 910         


Gln Ala Ala Trp Gln Lys Asp Gly Gln Pro Ile Ser Ser Asp Arg Phe 
        915                 920                 925             


Thr 
    


<210>  9986
<211>  808
<212>  PRT
<213>  Homo Sapiens

<400>  9986

Met Arg Leu Leu Leu Leu Val Pro Leu Leu Leu Ala Pro Ala Pro Gly 
1               5                   10                  15      


Ser Ser Ala Pro Lys Val Arg Arg Gln Ser Asp Thr Trp Gly Pro Trp 
            20                  25                  30          


Ser Gln Trp Ser Pro Cys Ser Arg Thr Cys Gly Gly Gly Val Ser Phe 
        35                  40                  45              


Arg Glu Arg Pro Cys Tyr Ser Gln Arg Arg Asp Gly Gly Ser Ser Cys 
    50                  55                  60                  


Val Gly Pro Ala Arg Ser His Arg Ser Cys Arg Thr Glu Ser Cys Pro 
65                  70                  75                  80  


Asp Gly Ala Arg Asp Phe Arg Ala Glu Gln Cys Ala Glu Phe Asp Gly 
                85                  90                  95      


Ala Glu Phe Gln Gly Arg Arg Tyr Arg Trp Leu Pro Tyr Tyr Ser Ala 
            100                 105                 110         


Pro Asn Lys Cys Glu Leu Asn Cys Ile Pro Lys Gly Glu Asn Phe Tyr 
        115                 120                 125             


Tyr Lys His Arg Glu Ala Val Val Asp Gly Thr Pro Cys Glu Pro Gly 
    130                 135                 140                 


Lys Arg Asp Val Cys Val Asp Gly Ser Cys Arg Val Val Gly Cys Asp 
145                 150                 155                 160 


His Glu Leu Asp Ser Ser Lys Gln Glu Asp Lys Cys Leu Arg Cys Gly 
                165                 170                 175     


Gly Asp Gly Thr Thr Cys Tyr Pro Val Ala Gly Thr Phe Asp Ala Asn 
            180                 185                 190         


Asp Leu Ser Arg Gly Tyr Asn Gln Ile Leu Ile Val Pro Met Gly Ala 
        195                 200                 205             


Thr Ser Ile Leu Ile Asp Glu Ala Ala Ala Ser Arg Asn Phe Leu Ala 
    210                 215                 220                 


Val Lys Asn Val Arg Gly Glu Tyr Tyr Leu Asn Gly His Trp Thr Ile 
225                 230                 235                 240 


Glu Ala Ala Arg Ala Leu Pro Ala Ala Ser Thr Ile Leu His Tyr Glu 
                245                 250                 255     


Arg Gly Ala Glu Gly Asp Leu Ala Pro Glu Arg Leu His Ala Arg Gly 
            260                 265                 270         


Pro Thr Ser Glu Pro Leu Val Ile Glu Leu Ile Ser Gln Glu Pro Asn 
        275                 280                 285             


Pro Gly Val His Tyr Glu Tyr His Leu Pro Leu Arg Arg Pro Ser Pro 
    290                 295                 300                 


Gly Phe Ser Trp Ser His Gly Ser Trp Ser Asp Cys Ser Ala Glu Cys 
305                 310                 315                 320 


Gly Gly Gly His Gln Ser Arg Leu Val Phe Cys Thr Ile Asp His Glu 
                325                 330                 335     


Ala Tyr Pro Asp His Met Cys Gln Arg Gln Pro Arg Pro Ala Asp Arg 
            340                 345                 350         


Arg Ser Cys Asn Leu His Pro Cys Pro Glu Thr Lys Arg Trp Lys Ala 
        355                 360                 365             


Gly Pro Trp Ala Pro Cys Ser Ala Ser Cys Gly Gly Gly Ser Gln Ser 
    370                 375                 380                 


Arg Ser Val Tyr Cys Ile Ser Ser Asp Gly Ala Gly Ile Gln Glu Ala 
385                 390                 395                 400 


Val Glu Glu Ala Glu Cys Ala Gly Leu Pro Gly Lys Pro Pro Ala Ile 
                405                 410                 415     


Gln Ala Cys Asn Leu Gln Arg Cys Ala Ala Trp Ser Pro Glu Pro Trp 
            420                 425                 430         


Gly Glu Cys Ser Val Ser Cys Gly Val Gly Val Arg Lys Arg Ser Val 
        435                 440                 445             


Thr Cys Arg Gly Glu Arg Gly Ser Leu Leu His Thr Ala Ala Cys Ser 
    450                 455                 460                 


Leu Glu Asp Arg Pro Pro Leu Thr Glu Pro Cys Val His Glu Asp Cys 
465                 470                 475                 480 


Pro Leu Leu Ser Asp Gln Ala Trp His Val Gly Thr Trp Gly Leu Cys 
                485                 490                 495     


Ser Lys Ser Cys Ser Ser Gly Thr Arg Arg Arg Gln Val Ile Cys Ala 
            500                 505                 510         


Ile Gly Pro Pro Ser His Cys Gly Ser Leu Gln His Ser Lys Pro Val 
        515                 520                 525             


Asp Val Glu Pro Cys Asn Thr Gln Pro Cys His Leu Pro Gln Glu Val 
    530                 535                 540                 


Pro Ser Met Gln Asp Val His Thr Pro Ala Ser Asn Pro Trp Met Pro 
545                 550                 555                 560 


Leu Gly Pro Gln Glu Ser Pro Ala Ser Asp Ser Arg Gly Gln Trp Trp 
                565                 570                 575     


Ala Ala Gln Glu His Pro Ser Ala Arg Gly Asp His Arg Gly Glu Arg 
            580                 585                 590         


Gly Asp Pro Arg Gly Asp Gln Gly Thr His Leu Ser Ala Leu Gly Pro 
        595                 600                 605             


Ala Pro Ser Leu Gln Gln Pro Pro Tyr Gln Gln Pro Leu Arg Ser Gly 
    610                 615                 620                 


Ser Gly Pro His Asp Cys Arg His Ser Pro His Gly Cys Cys Pro Asp 
625                 630                 635                 640 


Gly His Thr Ala Ser Leu Gly Pro Gln Trp Gln Gly Cys Pro Gly Ala 
                645                 650                 655     


Pro Cys Gln Gln Ser Arg Tyr Gly Cys Cys Pro Asp Arg Val Ser Val 
            660                 665                 670         


Ala Glu Gly Pro His His Ala Gly Cys Thr Lys Ser Tyr Gly Gly Asp 
        675                 680                 685             


Ser Thr Gly Gly Met Pro Arg Ser Arg Ala Val Ala Ser Thr Val His 
    690                 695                 700                 


Asn Thr His Gln Pro Gln Ala Gln Gln Asn Glu Pro Ser Glu Cys Arg 
705                 710                 715                 720 


Gly Ser Gln Phe Gly Cys Cys Tyr Asp Asn Val Ala Thr Ala Ala Gly 
                725                 730                 735     


Pro Leu Gly Glu Gly Cys Val Gly Gln Pro Ser His Gly Leu Ala Trp 
            740                 745                 750         


Gln Val Trp Ser Pro Arg Trp Cys Arg Gln Pro Trp Gly Ser Trp Cys 
        755                 760                 765             


Gly Ser Pro Ala Gln Thr Thr Leu Pro Arg Asn Pro Arg Leu Pro Gly 
    770                 775                 780                 


Arg Lys Met Ala Ser Pro Ser Pro Leu Thr Gly Val Cys Asp Gly Pro 
785                 790                 795                 800 


Pro Thr Ser Ser Asp Arg Cys Val 
                805             


<210>  9987
<211>  1262
<212>  PRT
<213>  Homo Sapiens

<400>  9987

Met Arg Leu Leu Leu Leu Val Pro Leu Leu Leu Ala Pro Ala Pro Gly 
1               5                   10                  15      


Ser Ser Ala Pro Lys Val Arg Arg Gln Ser Asp Thr Trp Gly Pro Trp 
            20                  25                  30          


Ser Gln Trp Ser Pro Cys Ser Arg Thr Cys Gly Gly Gly Val Ser Phe 
        35                  40                  45              


Arg Glu Arg Pro Cys Tyr Ser Gln Arg Arg Asp Gly Gly Ser Ser Cys 
    50                  55                  60                  


Val Gly Pro Ala Arg Ser His Arg Ser Cys Arg Thr Glu Ser Cys Pro 
65                  70                  75                  80  


Asp Gly Ala Arg Asp Phe Arg Ala Glu Gln Cys Ala Glu Phe Asp Gly 
                85                  90                  95      


Ala Glu Phe Gln Gly Arg Arg Tyr Arg Trp Leu Pro Tyr Tyr Ser Ala 
            100                 105                 110         


Pro Asn Lys Cys Glu Leu Asn Cys Ile Pro Lys Gly Glu Asn Phe Tyr 
        115                 120                 125             


Tyr Lys His Arg Glu Ala Val Val Asp Gly Thr Pro Cys Glu Pro Gly 
    130                 135                 140                 


Lys Arg Asp Val Cys Val Asp Gly Ser Cys Arg Val Val Gly Cys Asp 
145                 150                 155                 160 


His Glu Leu Asp Ser Ser Lys Gln Glu Asp Lys Cys Leu Arg Cys Gly 
                165                 170                 175     


Gly Asp Gly Thr Thr Cys Tyr Pro Val Ala Gly Thr Phe Asp Ala Asn 
            180                 185                 190         


Asp Leu Ser Arg Gly Tyr Asn Gln Ile Leu Ile Val Pro Met Gly Ala 
        195                 200                 205             


Thr Ser Ile Leu Ile Asp Glu Ala Ala Ala Ser Arg Asn Phe Leu Ala 
    210                 215                 220                 


Val Lys Asn Val Arg Gly Glu Tyr Tyr Leu Asn Gly His Trp Thr Ile 
225                 230                 235                 240 


Glu Ala Ala Arg Ala Leu Pro Ala Ala Ser Thr Ile Leu His Tyr Glu 
                245                 250                 255     


Arg Gly Ala Glu Gly Asp Leu Ala Pro Glu Arg Leu His Ala Arg Gly 
            260                 265                 270         


Pro Thr Ser Glu Pro Leu Val Ile Glu Leu Ile Ser Gln Glu Pro Asn 
        275                 280                 285             


Pro Gly Val His Tyr Glu Tyr His Leu Pro Leu Arg Arg Pro Ser Pro 
    290                 295                 300                 


Gly Phe Ser Trp Ser His Gly Ser Trp Ser Asp Cys Ser Ala Glu Cys 
305                 310                 315                 320 


Gly Gly Gly His Gln Ser Arg Leu Val Phe Cys Thr Ile Asp His Glu 
                325                 330                 335     


Ala Tyr Pro Asp His Met Cys Gln Arg Gln Pro Arg Pro Ala Asp Arg 
            340                 345                 350         


Arg Ser Cys Asn Leu His Pro Cys Pro Glu Thr Lys Arg Trp Lys Ala 
        355                 360                 365             


Gly Pro Trp Ala Pro Cys Ser Ala Ser Cys Gly Gly Gly Ser Gln Ser 
    370                 375                 380                 


Arg Ser Val Tyr Cys Ile Ser Ser Asp Gly Ala Gly Ile Gln Glu Ala 
385                 390                 395                 400 


Val Glu Glu Ala Glu Cys Ala Gly Leu Pro Gly Lys Pro Pro Ala Ile 
                405                 410                 415     


Gln Ala Cys Asn Leu Gln Arg Cys Ala Ala Trp Ser Pro Glu Pro Trp 
            420                 425                 430         


Gly Glu Cys Ser Val Ser Cys Gly Val Gly Val Arg Lys Arg Ser Val 
        435                 440                 445             


Thr Cys Arg Gly Glu Arg Gly Ser Leu Leu His Thr Ala Ala Cys Ser 
    450                 455                 460                 


Leu Glu Asp Arg Pro Pro Leu Thr Glu Pro Cys Val His Glu Asp Cys 
465                 470                 475                 480 


Pro Leu Leu Ser Asp Gln Ala Trp His Val Gly Thr Trp Gly Leu Cys 
                485                 490                 495     


Ser Lys Ser Cys Ser Ser Gly Thr Arg Arg Arg Gln Val Ile Cys Ala 
            500                 505                 510         


Ile Gly Pro Pro Ser His Cys Gly Ser Leu Gln His Ser Lys Pro Val 
        515                 520                 525             


Asp Val Glu Pro Cys Asn Thr Gln Pro Cys His Leu Pro Gln Glu Val 
    530                 535                 540                 


Pro Ser Met Gln Asp Val His Thr Pro Ala Ser Asn Pro Trp Met Pro 
545                 550                 555                 560 


Leu Gly Pro Gln Glu Ser Pro Ala Ser Asp Ser Arg Gly Gln Trp Trp 
                565                 570                 575     


Ala Ala Gln Glu His Pro Ser Ala Arg Gly Asp His Arg Gly Glu Arg 
            580                 585                 590         


Gly Asp Pro Arg Gly Asp Gln Gly Thr His Leu Ser Ala Leu Gly Pro 
        595                 600                 605             


Ala Pro Ser Leu Gln Gln Pro Pro Tyr Gln Gln Pro Leu Arg Ser Gly 
    610                 615                 620                 


Ser Gly Pro His Asp Cys Arg His Ser Pro His Gly Cys Cys Pro Asp 
625                 630                 635                 640 


Gly His Thr Ala Ser Leu Gly Pro Gln Trp Gln Gly Cys Pro Gly Ala 
                645                 650                 655     


Pro Cys Gln Gln Ser Arg Tyr Gly Cys Cys Pro Asp Arg Val Ser Val 
            660                 665                 670         


Ala Glu Gly Pro His His Ala Gly Cys Thr Lys Ser Tyr Gly Gly Asp 
        675                 680                 685             


Ser Thr Gly Gly Met Pro Arg Ser Arg Ala Val Ala Ser Thr Val His 
    690                 695                 700                 


Asn Thr His Gln Pro Gln Ala Gln Gln Asn Glu Pro Ser Glu Cys Arg 
705                 710                 715                 720 


Gly Ser Gln Phe Gly Cys Cys Tyr Asp Asn Val Ala Thr Ala Ala Gly 
                725                 730                 735     


Pro Leu Gly Glu Gly Cys Val Gly Gln Pro Ser His Asp Trp Ala Ala 
            740                 745                 750         


Arg Trp Tyr Phe Val Ala Ser Val Gly Gln Cys Asn Arg Phe Trp Tyr 
        755                 760                 765             


Gly Gly Cys His Gly Asn Ala Asn Asn Phe Ala Ser Glu Gln Glu Cys 
    770                 775                 780                 


Met Ser Ser Cys Gln Gly Ser Leu His Gly Pro Arg Arg Pro Gln Pro 
785                 790                 795                 800 


Gly Ala Ser Gly Arg Ser Thr His Thr Asp Gly Gly Gly Ser Ser Pro 
                805                 810                 815     


Ala Gly Glu Gln Glu Pro Ser Gln His Arg Thr Gly Ala Ala Val Gln 
            820                 825                 830         


Arg Lys Pro Trp Pro Ser Gly Gly Leu Trp Arg Gln Asp Gln Gln Pro 
        835                 840                 845             


Gly Pro Gly Glu Ala Pro His Thr Gln Ala Phe Gly Glu Trp Pro Trp 
    850                 855                 860                 


Gly Gln Glu Leu Gly Ser Arg Ala Pro Gly Leu Gly Gly Asp Ala Gly 
865                 870                 875                 880 


Ser Pro Ala Pro Pro Phe His Ser Ser Ser Tyr Arg Ile Ser Leu Ala 
                885                 890                 895     


Gly Val Glu Pro Ser Leu Val Gln Ala Ala Leu Gly Gln Leu Val Arg 
            900                 905                 910         


Leu Ser Cys Ser Asp Asp Thr Ala Pro Glu Ser Gln Ala Ala Trp Gln 
        915                 920                 925             


Lys Asp Gly Gln Pro Ile Ser Ser Asp Arg His Arg Leu Gln Phe Asp 
    930                 935                 940                 


Gly Ser Leu Ile Ile His Pro Leu Gln Ala Glu Asp Ala Gly Thr Tyr 
945                 950                 955                 960 


Ser Cys Gly Ser Thr Arg Pro Gly Arg Asp Ser Gln Lys Ile Gln Leu 
                965                 970                 975     


Arg Ile Ile Gly Gly Asp Met Ala Val Leu Ser Glu Ala Glu Leu Ser 
            980                 985                 990         


Arg Phe Pro Gln Pro Arg Asp Pro  Ala Gln Asp Phe Gly  Gln Ala Gly 
        995                 1000                 1005             


Ala Ala  Gly Pro Leu Gly Ala  Ile Pro Ser Ser His  Pro Gln Pro 
    1010                 1015                 1020             


Ala Asn  Arg Leu Arg Leu Asp  Gln Asn Gln Pro Arg  Val Val Asp 
    1025                 1030                 1035             


Ala Ser  Pro Gly Gln Arg Ile  Arg Met Thr Cys Arg  Ala Glu Gly 
    1040                 1045                 1050             


Phe Pro  Pro Pro Ala Ile Glu  Trp Gln Arg Asp Gly  Gln Pro Val 
    1055                 1060                 1065             


Ser Ser  Pro Arg His Gln Leu  Gln Pro Asp Gly Ser  Leu Val Ile 
    1070                 1075                 1080             


Ser Arg  Val Ala Val Glu Asp  Gly Gly Phe Tyr Thr  Cys Val Ala 
    1085                 1090                 1095             


Phe Asn  Gly Gln Asp Arg Asp  Gln Arg Trp Val Gln  Leu Arg Val 
    1100                 1105                 1110             


Leu Gly  Glu Leu Thr Ile Ser  Gly Leu Pro Pro Thr  Val Thr Val 
    1115                 1120                 1125             


Pro Glu  Gly Asp Thr Ala Arg  Leu Leu Cys Val Val  Ala Gly Glu 
    1130                 1135                 1140             


Ser Val  Asn Ile Arg Trp Ser  Arg Asn Gly Leu Pro  Val Gln Ala 
    1145                 1150                 1155             


Asp Gly  His Arg Val His Gln  Ser Pro Asp Gly Thr  Leu Leu Ile 
    1160                 1165                 1170             


Tyr Asn  Leu Arg Ala Arg Asp  Glu Gly Ser Tyr Thr  Cys Ser Ala 
    1175                 1180                 1185             


Tyr Gln  Gly Ser Gln Ala Val  Ser Arg Ser Thr Glu  Val Lys Val 
    1190                 1195                 1200             


Val Ser  Pro Ala Pro Thr Ala  Gln Pro Arg Asp Pro  Gly Arg Asp 
    1205                 1210                 1215             


Cys Val  Asp Gln Pro Glu Leu  Ala Asn Cys Asp Leu  Ile Leu Gln 
    1220                 1225                 1230             


Ala Gln  Leu Cys Gly Asn Glu  Tyr Tyr Ser Ser Phe  Cys Cys Ala 
    1235                 1240                 1245             


Ser Cys  Ser Arg Phe Gln Pro  His Ala Gln Pro Ile  Trp Gln 
    1250                 1255                 1260         


<210>  9988
<211>  1278
<212>  PRT
<213>  Homo Sapiens

<400>  9988

Met Arg Leu Leu Leu Leu Val Pro Leu Leu Leu Ala Pro Ala Pro Gly 
1               5                   10                  15      


Ser Ser Ala Pro Lys Val Arg Arg Gln Ser Asp Thr Trp Gly Pro Trp 
            20                  25                  30          


Ser Gln Trp Ser Pro Cys Ser Arg Thr Cys Gly Gly Gly Val Ser Phe 
        35                  40                  45              


Arg Glu Arg Pro Cys Tyr Ser Gln Arg Arg Asp Gly Gly Ser Ser Cys 
    50                  55                  60                  


Val Gly Pro Ala Arg Ser His Arg Ser Cys Arg Thr Glu Ser Cys Pro 
65                  70                  75                  80  


Asp Gly Ala Arg Asp Phe Arg Ala Glu Gln Cys Ala Glu Phe Asp Gly 
                85                  90                  95      


Ala Glu Phe Gln Gly Arg Arg Tyr Arg Trp Leu Pro Tyr Tyr Ser Ala 
            100                 105                 110         


Pro Asn Lys Cys Glu Leu Asn Cys Ile Pro Lys Gly Glu Asn Phe Tyr 
        115                 120                 125             


Tyr Lys His Arg Glu Ala Val Val Asp Gly Thr Pro Cys Glu Pro Gly 
    130                 135                 140                 


Lys Arg Asp Val Cys Val Asp Gly Ser Cys Arg Val Val Gly Cys Asp 
145                 150                 155                 160 


His Glu Leu Asp Ser Ser Lys Gln Glu Asp Lys Cys Leu Arg Cys Gly 
                165                 170                 175     


Gly Asp Gly Thr Thr Cys Tyr Pro Val Ala Gly Thr Phe Asp Ala Asn 
            180                 185                 190         


Asp Leu Ser Arg Gly Tyr Asn Gln Ile Leu Ile Val Pro Met Gly Ala 
        195                 200                 205             


Thr Ser Ile Leu Ile Asp Glu Ala Ala Ala Ser Arg Asn Phe Leu Ala 
    210                 215                 220                 


Val Lys Asn Val Arg Gly Glu Tyr Tyr Leu Asn Gly His Trp Thr Ile 
225                 230                 235                 240 


Glu Ala Ala Arg Ala Leu Pro Ala Ala Ser Thr Ile Leu His Tyr Glu 
                245                 250                 255     


Arg Gly Ala Glu Gly Asp Leu Ala Pro Glu Arg Leu His Ala Arg Gly 
            260                 265                 270         


Pro Thr Ser Glu Pro Leu Val Ile Glu Leu Ile Ser Gln Glu Pro Asn 
        275                 280                 285             


Pro Gly Val His Tyr Glu Tyr His Leu Pro Leu Arg Arg Pro Ser Pro 
    290                 295                 300                 


Gly Phe Ser Trp Ser His Gly Ser Trp Ser Asp Cys Ser Ala Glu Cys 
305                 310                 315                 320 


Gly Gly Gly His Gln Ser Arg Leu Val Phe Cys Thr Ile Asp His Glu 
                325                 330                 335     


Ala Tyr Pro Asp His Met Cys Gln Arg Gln Pro Arg Pro Ala Asp Arg 
            340                 345                 350         


Arg Ser Cys Asn Leu His Pro Cys Pro Glu Thr Lys Arg Trp Lys Ala 
        355                 360                 365             


Gly Pro Trp Ala Pro Cys Ser Ala Ser Cys Gly Gly Gly Ser Gln Ser 
    370                 375                 380                 


Arg Ser Val Tyr Cys Ile Ser Ser Asp Gly Ala Gly Ile Gln Glu Ala 
385                 390                 395                 400 


Val Glu Glu Ala Glu Cys Ala Gly Leu Pro Gly Lys Pro Pro Ala Ile 
                405                 410                 415     


Gln Ala Cys Asn Leu Gln Arg Cys Ala Ala Trp Ser Pro Glu Pro Trp 
            420                 425                 430         


Gly Glu Cys Ser Val Ser Cys Gly Val Gly Val Arg Lys Arg Ser Val 
        435                 440                 445             


Thr Cys Arg Gly Glu Arg Gly Ser Leu Leu His Thr Ala Ala Cys Ser 
    450                 455                 460                 


Leu Glu Asp Arg Pro Pro Leu Thr Glu Pro Cys Val His Glu Asp Cys 
465                 470                 475                 480 


Pro Leu Leu Ser Asp Gln Ala Trp His Val Gly Thr Trp Gly Leu Cys 
                485                 490                 495     


Ser Lys Ser Cys Ser Ser Gly Thr Arg Arg Arg Gln Val Ile Cys Ala 
            500                 505                 510         


Ile Gly Pro Pro Ser His Cys Gly Ser Leu Gln His Ser Lys Pro Val 
        515                 520                 525             


Asp Val Glu Pro Cys Asn Thr Gln Pro Cys His Leu Pro Gln Glu Val 
    530                 535                 540                 


Pro Ser Met Gln Asp Val His Thr Pro Ala Ser Asn Pro Trp Met Pro 
545                 550                 555                 560 


Leu Gly Pro Gln Glu Ser Pro Ala Ser Asp Ser Arg Gly Gln Trp Trp 
                565                 570                 575     


Ala Ala Gln Glu His Pro Ser Ala Arg Gly Asp His Arg Gly Glu Arg 
            580                 585                 590         


Gly Asp Pro Arg Gly Asp Gln Gly Thr His Leu Ser Ala Leu Gly Pro 
        595                 600                 605             


Ala Pro Ser Leu Gln Gln Pro Pro Tyr Gln Gln Pro Leu Arg Ser Gly 
    610                 615                 620                 


Ser Gly Pro His Asp Cys Arg His Ser Pro His Gly Cys Cys Pro Asp 
625                 630                 635                 640 


Gly His Thr Ala Ser Leu Gly Pro Gln Trp Gln Gly Cys Pro Gly Ala 
                645                 650                 655     


Pro Cys Gln Gln Ser Arg Tyr Gly Cys Cys Pro Asp Arg Val Ser Val 
            660                 665                 670         


Ala Glu Gly Pro His His Ala Gly Cys Thr Lys Ser Tyr Gly Gly Asp 
        675                 680                 685             


Ser Thr Gly Gly Met Pro Arg Ser Arg Ala Val Ala Ser Thr Val His 
    690                 695                 700                 


Asn Thr His Gln Pro Gln Ala Gln Gln Asn Glu Pro Ser Glu Cys Arg 
705                 710                 715                 720 


Gly Ser Gln Phe Gly Cys Cys Tyr Asp Asn Val Ala Thr Ala Ala Gly 
                725                 730                 735     


Pro Leu Gly Glu Gly Cys Val Gly Gln Pro Ser His Ala Tyr Pro Val 
            740                 745                 750         


Arg Cys Leu Leu Pro Ser Ala His Gly Ser Cys Ala Asp Trp Ala Ala 
        755                 760                 765             


Arg Trp Tyr Phe Val Ala Ser Val Gly Gln Cys Asn Arg Phe Trp Tyr 
    770                 775                 780                 


Gly Gly Cys His Gly Asn Ala Asn Asn Phe Ala Ser Glu Gln Glu Cys 
785                 790                 795                 800 


Met Ser Ser Cys Gln Gly Ser Leu His Gly Pro Arg Arg Pro Gln Pro 
                805                 810                 815     


Gly Ala Ser Gly Arg Ser Thr His Thr Asp Gly Gly Gly Ser Ser Pro 
            820                 825                 830         


Ala Gly Glu Gln Glu Pro Ser Gln His Arg Thr Gly Ala Ala Val Gln 
        835                 840                 845             


Arg Lys Pro Trp Pro Ser Gly Gly Leu Trp Arg Gln Asp Gln Gln Pro 
    850                 855                 860                 


Gly Pro Gly Glu Ala Pro His Thr Gln Ala Phe Gly Glu Trp Pro Trp 
865                 870                 875                 880 


Gly Gln Glu Leu Gly Ser Arg Ala Pro Gly Leu Gly Gly Asp Ala Gly 
                885                 890                 895     


Ser Pro Ala Pro Pro Phe His Ser Ser Ser Tyr Arg Ile Ser Leu Ala 
            900                 905                 910         


Gly Val Glu Pro Ser Leu Val Gln Ala Ala Leu Gly Gln Leu Val Arg 
        915                 920                 925             


Leu Ser Cys Ser Asp Asp Thr Ala Pro Glu Ser Gln Ala Ala Trp Gln 
    930                 935                 940                 


Lys Asp Gly Gln Pro Ile Ser Ser Asp Arg His Arg Leu Gln Phe Asp 
945                 950                 955                 960 


Gly Ser Leu Ile Ile His Pro Leu Gln Ala Glu Asp Ala Gly Thr Tyr 
                965                 970                 975     


Ser Cys Gly Ser Thr Arg Pro Gly Arg Asp Ser Gln Lys Ile Gln Leu 
            980                 985                 990         


Arg Ile Ile Gly Gly Asp Met Ala  Val Leu Ser Glu Ala  Glu Leu Ser 
        995                 1000                 1005             


Arg Phe  Pro Gln Pro Arg Asp  Pro Ala Gln Asp Phe  Gly Gln Ala 
    1010                 1015                 1020             


Gly Ala  Ala Gly Pro Leu Gly  Ala Ile Pro Ser Ser  His Pro Gln 
    1025                 1030                 1035             


Pro Ala  Asn Arg Leu Arg Leu  Asp Gln Asn Gln Pro  Arg Val Val 
    1040                 1045                 1050             


Asp Ala  Ser Pro Gly Gln Arg  Ile Arg Met Thr Cys  Arg Ala Glu 
    1055                 1060                 1065             


Gly Phe  Pro Pro Pro Ala Ile  Glu Trp Gln Arg Asp  Gly Gln Pro 
    1070                 1075                 1080             


Val Ser  Ser Pro Arg His Gln  Leu Gln Pro Asp Gly  Ser Leu Val 
    1085                 1090                 1095             


Ile Ser  Arg Val Ala Val Glu  Asp Gly Gly Phe Tyr  Thr Cys Val 
    1100                 1105                 1110             


Ala Phe  Asn Gly Gln Asp Arg  Asp Gln Arg Trp Val  Gln Leu Arg 
    1115                 1120                 1125             


Val Leu  Gly Glu Leu Thr Ile  Ser Gly Leu Pro Pro  Thr Val Thr 
    1130                 1135                 1140             


Val Pro  Glu Gly Asp Thr Ala  Arg Leu Leu Cys Val  Val Ala Gly 
    1145                 1150                 1155             


Glu Ser  Val Asn Ile Arg Trp  Ser Arg Asn Gly Leu  Pro Val Gln 
    1160                 1165                 1170             


Ala Asp  Gly His Arg Val His  Gln Ser Pro Asp Gly  Thr Leu Leu 
    1175                 1180                 1185             


Ile Tyr  Asn Leu Arg Ala Arg  Asp Glu Gly Ser Tyr  Thr Cys Ser 
    1190                 1195                 1200             


Ala Tyr  Gln Gly Ser Gln Ala  Val Ser Arg Ser Thr  Glu Val Lys 
    1205                 1210                 1215             


Val Val  Ser Pro Ala Pro Thr  Ala Gln Pro Arg Asp  Pro Gly Arg 
    1220                 1225                 1230             


Asp Cys  Val Asp Gln Pro Glu  Leu Ala Asn Cys Asp  Leu Ile Leu 
    1235                 1240                 1245             


Gln Ala  Gln Leu Cys Gly Asn  Glu Tyr Tyr Ser Ser  Phe Cys Cys 
    1250                 1255                 1260             


Ala Ser  Cys Ser Arg Phe Gln  Pro His Ala Gln Pro  Ile Trp Gln 
    1265                 1270                 1275             


<210>  9989
<211>  1278
<212>  PRT
<213>  Homo Sapiens

<400>  9989

Met Arg Leu Leu Leu Leu Val Pro Leu Leu Leu Ala Pro Ala Pro Gly 
1               5                   10                  15      


Ser Ser Ala Pro Lys Val Arg Arg Gln Ser Asp Thr Trp Gly Pro Trp 
            20                  25                  30          


Ser Gln Trp Ser Pro Cys Ser Arg Thr Cys Gly Gly Gly Val Ser Phe 
        35                  40                  45              


Arg Glu Arg Pro Cys Tyr Ser Gln Arg Arg Asp Gly Gly Ser Ser Cys 
    50                  55                  60                  


Val Gly Pro Ala Arg Ser His Arg Ser Cys Arg Thr Glu Ser Cys Pro 
65                  70                  75                  80  


Asp Gly Ala Arg Asp Phe Arg Ala Glu Gln Cys Ala Glu Phe Asp Gly 
                85                  90                  95      


Ala Glu Phe Gln Gly Arg Arg Tyr Arg Trp Leu Pro Tyr Tyr Ser Ala 
            100                 105                 110         


Pro Asn Lys Cys Glu Leu Asn Cys Ile Pro Lys Gly Glu Asn Phe Tyr 
        115                 120                 125             


Tyr Lys His Arg Glu Ala Val Val Asp Gly Thr Pro Cys Glu Pro Gly 
    130                 135                 140                 


Lys Arg Asp Val Cys Val Asp Gly Ser Cys Arg Val Val Gly Cys Asp 
145                 150                 155                 160 


His Glu Leu Asp Ser Ser Lys Gln Glu Asp Lys Cys Leu Arg Cys Gly 
                165                 170                 175     


Gly Asp Gly Thr Thr Cys Tyr Pro Val Ala Gly Thr Phe Asp Ala Asn 
            180                 185                 190         


Asp Leu Ser Arg Gly Tyr Asn Gln Ile Leu Ile Val Pro Met Gly Ala 
        195                 200                 205             


Thr Ser Ile Leu Ile Asp Glu Ala Ala Ala Ser Arg Asn Phe Leu Ala 
    210                 215                 220                 


Val Lys Asn Val Arg Gly Glu Tyr Tyr Leu Asn Gly His Trp Thr Ile 
225                 230                 235                 240 


Glu Ala Ala Arg Ala Leu Pro Ala Ala Ser Thr Ile Leu His Tyr Glu 
                245                 250                 255     


Arg Gly Ala Glu Gly Asp Leu Ala Pro Glu Arg Leu His Ala Arg Gly 
            260                 265                 270         


Pro Thr Ser Glu Pro Leu Val Ile Glu Leu Ile Ser Gln Glu Pro Asn 
        275                 280                 285             


Pro Gly Val His Tyr Glu Tyr His Leu Pro Leu Arg Arg Pro Ser Pro 
    290                 295                 300                 


Gly Phe Ser Trp Ser His Gly Ser Trp Ser Asp Cys Ser Ala Glu Cys 
305                 310                 315                 320 


Gly Gly Gly His Gln Ser Arg Leu Val Phe Cys Thr Ile Asp His Glu 
                325                 330                 335     


Ala Tyr Pro Asp His Met Cys Gln Arg Gln Pro Arg Pro Ala Asp Arg 
            340                 345                 350         


Arg Ser Cys Asn Leu His Pro Cys Pro Glu Thr Lys Arg Trp Lys Ala 
        355                 360                 365             


Gly Pro Trp Ala Pro Cys Ser Ala Ser Cys Gly Gly Gly Ser Gln Ser 
    370                 375                 380                 


Arg Ser Val Tyr Cys Ile Ser Ser Asp Gly Ala Gly Ile Gln Glu Ala 
385                 390                 395                 400 


Val Glu Glu Ala Glu Cys Ala Gly Leu Pro Gly Lys Pro Pro Ala Ile 
                405                 410                 415     


Gln Ala Cys Asn Leu Gln Arg Cys Ala Ala Trp Ser Pro Glu Pro Trp 
            420                 425                 430         


Gly Glu Cys Ser Val Ser Cys Gly Val Gly Val Arg Lys Arg Ser Val 
        435                 440                 445             


Thr Cys Arg Gly Glu Arg Gly Ser Leu Leu His Thr Ala Ala Cys Ser 
    450                 455                 460                 


Leu Glu Asp Arg Pro Pro Leu Thr Glu Pro Cys Val His Glu Asp Cys 
465                 470                 475                 480 


Pro Leu Leu Ser Asp Gln Ala Trp His Val Gly Thr Trp Gly Leu Cys 
                485                 490                 495     


Ser Lys Ser Cys Ser Ser Gly Thr Arg Arg Arg Gln Val Ile Cys Ala 
            500                 505                 510         


Ile Gly Pro Pro Ser His Cys Gly Ser Leu Gln His Ser Lys Pro Val 
        515                 520                 525             


Asp Val Glu Pro Cys Asn Thr Gln Pro Cys His Leu Pro Gln Glu Val 
    530                 535                 540                 


Pro Ser Met Gln Asp Val His Thr Pro Ala Ser Asn Pro Trp Met Pro 
545                 550                 555                 560 


Leu Gly Pro Gln Glu Ser Pro Ala Ser Asp Ser Arg Gly Gln Trp Trp 
                565                 570                 575     


Ala Ala Gln Glu His Pro Ser Ala Arg Gly Asp His Arg Gly Glu Arg 
            580                 585                 590         


Gly Asp Pro Arg Gly Asp Gln Gly Thr His Leu Ser Ala Leu Gly Pro 
        595                 600                 605             


Ala Pro Ser Leu Gln Gln Pro Pro Tyr Gln Gln Pro Leu Arg Ser Gly 
    610                 615                 620                 


Ser Gly Pro His Asp Cys Arg His Ser Pro His Gly Cys Cys Pro Asp 
625                 630                 635                 640 


Gly His Thr Ala Ser Leu Gly Pro Gln Trp Gln Gly Cys Pro Gly Ala 
                645                 650                 655     


Pro Cys Gln Gln Ser Arg Tyr Gly Cys Cys Pro Asp Arg Val Ser Val 
            660                 665                 670         


Ala Glu Gly Pro His His Ala Gly Cys Thr Lys Ser Tyr Gly Gly Asp 
        675                 680                 685             


Ser Thr Gly Gly Met Pro Arg Ser Arg Ala Val Ala Ser Thr Val His 
    690                 695                 700                 


Asn Thr His Gln Pro Gln Ala Gln Gln Asn Glu Pro Ser Glu Cys Arg 
705                 710                 715                 720 


Gly Ser Gln Phe Gly Cys Cys Tyr Asp Asn Val Ala Thr Ala Ala Gly 
                725                 730                 735     


Pro Leu Gly Glu Gly Cys Val Gly Gln Pro Ser His Ala Tyr Pro Val 
            740                 745                 750         


Arg Cys Leu Leu Pro Ser Ala His Gly Ser Cys Ala Asp Trp Ala Ala 
        755                 760                 765             


Arg Trp Tyr Phe Val Ala Ser Val Gly Gln Cys Asn Arg Phe Trp Tyr 
    770                 775                 780                 


Gly Gly Cys His Gly Asn Ala Asn Asn Phe Ala Ser Glu Gln Glu Cys 
785                 790                 795                 800 


Met Ser Ser Cys Gln Gly Ser Leu His Gly Pro Arg Arg Pro Gln Pro 
                805                 810                 815     


Gly Ala Ser Gly Arg Ser Thr His Thr Asp Gly Gly Gly Ser Ser Pro 
            820                 825                 830         


Ala Gly Glu Gln Glu Pro Ser Gln His Arg Thr Gly Ala Ala Val Gln 
        835                 840                 845             


Arg Lys Pro Trp Pro Ser Gly Gly Leu Trp Arg Gln Asp Gln Gln Pro 
    850                 855                 860                 


Gly Pro Gly Glu Ala Pro His Thr Gln Ala Phe Gly Glu Trp Pro Trp 
865                 870                 875                 880 


Gly Gln Glu Leu Gly Ser Arg Ala Pro Gly Leu Gly Gly Asp Ala Gly 
                885                 890                 895     


Ser Pro Ala Pro Pro Phe His Ser Ser Ser Tyr Arg Ile Ser Leu Ala 
            900                 905                 910         


Gly Val Glu Pro Ser Leu Val Gln Ala Ala Leu Gly Gln Leu Val Arg 
        915                 920                 925             


Leu Ser Cys Ser Asp Asp Thr Ala Pro Glu Ser Gln Ala Ala Trp Gln 
    930                 935                 940                 


Lys Asp Gly Gln Pro Ile Ser Ser Asp Arg His Arg Leu Gln Phe Asp 
945                 950                 955                 960 


Gly Ser Leu Ile Ile His Pro Leu Gln Ala Glu Asp Ala Gly Thr Tyr 
                965                 970                 975     


Ser Cys Gly Ser Thr Arg Pro Gly Arg Asp Ser Gln Lys Ile Gln Leu 
            980                 985                 990         


Arg Ile Ile Gly Gly Asp Met Ala  Val Leu Ser Glu Ala  Glu Leu Ser 
        995                 1000                 1005             


Arg Phe  Pro Gln Pro Arg Asp  Pro Ala Gln Asp Phe  Gly Gln Ala 
    1010                 1015                 1020             


Gly Ala  Ala Gly Pro Leu Gly  Ala Ile Pro Ser Ser  His Pro Gln 
    1025                 1030                 1035             


Pro Ala  Asn Arg Leu Arg Leu  Asp Gln Asn Gln Pro  Arg Val Val 
    1040                 1045                 1050             


Asp Ala  Ser Pro Gly Gln Arg  Ile Arg Met Thr Cys  Arg Ala Glu 
    1055                 1060                 1065             


Gly Phe  Pro Pro Pro Ala Ile  Glu Trp Gln Arg Asp  Gly Gln Pro 
    1070                 1075                 1080             


Val Ser  Ser Pro Arg His Gln  Leu Gln Pro Asp Gly  Ser Leu Val 
    1085                 1090                 1095             


Ile Ser  Arg Val Ala Val Glu  Asp Gly Gly Phe Tyr  Thr Cys Val 
    1100                 1105                 1110             


Ala Phe  Asn Gly Gln Asp Arg  Asp Gln Arg Trp Val  Gln Leu Arg 
    1115                 1120                 1125             


Val Leu  Gly Glu Leu Thr Ile  Ser Gly Leu Pro Pro  Thr Val Thr 
    1130                 1135                 1140             


Val Pro  Glu Gly Asp Thr Ala  Arg Leu Leu Cys Val  Val Ala Gly 
    1145                 1150                 1155             


Glu Ser  Val Asn Ile Arg Trp  Ser Arg Asn Gly Leu  Pro Val Gln 
    1160                 1165                 1170             


Ala Asp  Gly His Arg Val His  Gln Ser Pro Asp Gly  Thr Leu Leu 
    1175                 1180                 1185             


Ile Tyr  Asn Leu Arg Ala Arg  Asp Glu Gly Ser Tyr  Thr Cys Ser 
    1190                 1195                 1200             


Ala Tyr  Gln Gly Ser Gln Ala  Val Ser Arg Ser Thr  Glu Val Lys 
    1205                 1210                 1215             


Val Val  Ser Pro Ala Pro Thr  Ala Gln Pro Arg Asp  Pro Gly Arg 
    1220                 1225                 1230             


Asp Cys  Val Asp Gln Pro Glu  Leu Ala Asn Cys Asp  Leu Ile Leu 
    1235                 1240                 1245             


Gln Ala  Gln Leu Cys Gly Asn  Glu Tyr Tyr Ser Ser  Phe Cys Cys 
    1250                 1255                 1260             


Ala Ser  Cys Ser Arg Phe Gln  Pro His Ala Gln Pro  Ile Trp Gln 
    1265                 1270                 1275             


<210>  9990
<211>  214
<212>  PRT
<213>  Homo Sapiens

<400>  9990

Val His Asn Thr His Gln Pro Gln Ala Gln Gln Asn Glu Pro Ser Glu 
1               5                   10                  15      


Cys Arg Gly Ser Gln Phe Gly Cys Cys Tyr Asp Asn Val Ala Thr Ala 
            20                  25                  30          


Ala Gly Pro Leu Gly Glu Gly Cys Val Gly Gln Pro Ser His Ala Tyr 
        35                  40                  45              


Pro Val Arg Cys Leu Leu Pro Ser Ala His Gly Ser Cys Ala Asp Trp 
    50                  55                  60                  


Ala Ala Arg Trp Tyr Phe Val Ala Ser Val Gly Gln Cys Asn Arg Phe 
65                  70                  75                  80  


Trp Tyr Gly Gly Cys His Gly Asn Ala Asn Asn Phe Ala Ser Glu Gln 
                85                  90                  95      


Glu Cys Met Ser Ser Cys Gln Gly Ser Leu His Gly Pro Arg Arg Pro 
            100                 105                 110         


Gln Pro Gly Ala Ser Gly Arg Ser Thr His Thr Asp Gly Gly Gly Ser 
        115                 120                 125             


Ser Pro Ala Gly Glu Gln Glu Pro Ser Gln His Arg Thr Gly Ala Ala 
    130                 135                 140                 


Val Gln Arg Lys Pro Trp Pro Ser Gly Gly Leu Trp Arg Gln Asp Gln 
145                 150                 155                 160 


Gln Pro Gly Pro Gly Glu Ala Pro His Thr Gln Ala Phe Gly Glu Trp 
                165                 170                 175     


Pro Trp Gly Gln Glu Leu Gly Ser Arg Ala Pro Gly Leu Gly Gly Asp 
            180                 185                 190         


Ala Gly Ser Pro Ala Pro Pro Phe His Ser Ser Ser Tyr Arg Ser His 
        195                 200                 205             


Phe Pro Pro Leu Gln Asp 
    210                 


<210>  9991
<211>  311
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9991

Xaa Cys Met Ser Ser Cys Gln Gly Ser Leu His Gly Pro Arg Arg Pro 
1               5                   10                  15      


Gln Pro Gly Ala Ser Gly Arg Ser Thr His Thr Asp Gly Gly Gly Ser 
            20                  25                  30          


Ser Pro Ala Gly Glu Gln Glu Pro Ser Gln His Arg Thr Gly Ala Ala 
        35                  40                  45              


Val Gln Arg Lys Pro Trp Pro Ser Gly Gly Leu Trp Arg Gln Asp Gln 
    50                  55                  60                  


Gln Pro Gly Pro Gly Glu Ala Pro His Thr Gln Ala Phe Gly Glu Trp 
65                  70                  75                  80  


Pro Trp Gly Gln Glu Leu Gly Ser Arg Ala Pro Gly Leu Gly Gly Asp 
                85                  90                  95      


Ala Gly Ser Pro Ala Pro Pro Phe His Ser Ser Ser Tyr Arg Ile Ser 
            100                 105                 110         


Leu Ala Gly Val Glu Pro Ser Leu Val Gln Ala Ala Leu Gly Gln Leu 
        115                 120                 125             


Val Arg Leu Ser Cys Ser Asp Asp Thr Ala Pro Glu Ser Gln Ala Ala 
    130                 135                 140                 


Trp Gln Lys Asp Gly Gln Pro Ile Ser Ser Asp Arg His Arg Leu Gln 
145                 150                 155                 160 


Phe Asp Gly Ser Leu Ile Ile His Pro Leu Gln Ala Glu Asp Ala Gly 
                165                 170                 175     


Thr Tyr Ser Cys Gly Ser Thr Arg Pro Gly Arg Asp Ser Gln Lys Ile 
            180                 185                 190         


Gln Leu Arg Ile Ile Gly Gly Asp Met Ala Val Leu Ser Glu Ala Glu 
        195                 200                 205             


Leu Ser Arg Phe Pro Gln Pro Arg Asp Pro Ala Gln Asp Phe Gly Gln 
    210                 215                 220                 


Ala Gly Ala Ala Gly Pro Leu Gly Ala Ile Pro Ser Ser His Pro Gln 
225                 230                 235                 240 


Pro Ala Asn Arg Leu Arg Leu Asp Gln Asn Gln Pro Arg Val Val Asp 
                245                 250                 255     


Ala Ser Pro Gly Gln Arg Ile Arg Met Thr Cys Arg Ala Glu Gly Phe 
            260                 265                 270         


Pro Pro Pro Ala Ile Glu Trp Gln Arg Asp Gly Gln Pro Val Ser Ser 
        275                 280                 285             


Pro Ser Thr His Arg Pro Ala Gln Gly Pro Trp Gln Gly Leu Arg Arg 
    290                 295                 300                 


Pro Ala Arg Ala Gly Gln Leu 
305                 310     


<210>  9992
<211>  1627
<212>  PRT
<213>  Homo Sapiens

<400>  9992

Met Arg Leu Trp Ser Trp Val Leu His Leu Gly Leu Leu Ser Ala Ala 
1               5                   10                  15      


Leu Gly Cys Gly Leu Ala Glu Arg Pro Arg Arg Ala Arg Arg Asp Pro 
            20                  25                  30          


Arg Ala Gly Arg Pro Pro Arg Pro Ala Ala Gly Pro Ala Thr Cys Ala 
        35                  40                  45              


Thr Arg Ala Ala Arg Gly Arg Arg Ala Ser Pro Pro Pro Pro Pro Pro 
    50                  55                  60                  


Pro Gly Gly Ala Trp Glu Ala Val Arg Val Pro Arg Arg Arg Gln Gln 
65                  70                  75                  80  


Arg Glu Ala Arg Gly Ala Thr Glu Glu Pro Ser Pro Pro Ser Arg Ala 
                85                  90                  95      


Leu Tyr Phe Ser Gly Arg Gly Glu Gln Leu Arg Leu Arg Ala Asp Leu 
            100                 105                 110         


Glu Leu Pro Arg Asp Ala Phe Thr Leu Gln Val Trp Leu Arg Ala Glu 
        115                 120                 125             


Gly Gly Gln Arg Ser Pro Ala Val Ile Thr Gly Leu Tyr Asp Lys Cys 
    130                 135                 140                 


Ser Tyr Ile Ser Arg Asp Arg Gly Trp Val Val Gly Ile His Thr Ile 
145                 150                 155                 160 


Ser Asp Gln Asp Asn Lys Asp Pro Arg Tyr Phe Phe Ser Leu Lys Thr 
                165                 170                 175     


Asp Arg Ala Arg Gln Val Thr Thr Ile Asn Ala His Arg Ser Tyr Leu 
            180                 185                 190         


Pro Gly Gln Trp Val Tyr Leu Ala Ala Thr Tyr Asp Gly Gln Phe Met 
        195                 200                 205             


Lys Leu Tyr Val Asn Gly Ala Gln Val Ala Thr Ser Gly Glu Gln Val 
    210                 215                 220                 


Gly Gly Ile Phe Ser Pro Leu Thr Gln Lys Cys Lys Val Leu Met Leu 
225                 230                 235                 240 


Gly Gly Ser Ala Leu Asn His Asn Tyr Arg Gly Tyr Ile Glu His Phe 
                245                 250                 255     


Ser Leu Trp Lys Val Ala Arg Thr Gln Arg Glu Ile Leu Ser Asp Met 
            260                 265                 270         


Glu Thr His Gly Ala His Thr Ala Leu Pro Gln Leu Leu Leu Gln Glu 
        275                 280                 285             


Asn Trp Asp Asn Val Lys His Ala Trp Ser Pro Met Lys Asp Gly Ser 
    290                 295                 300                 


Ser Pro Lys Val Glu Phe Ser Asn Ala His Gly Phe Leu Leu Asp Thr 
305                 310                 315                 320 


Ser Leu Glu Pro Pro Leu Cys Gly Gln Thr Leu Cys Asp Asn Thr Glu 
                325                 330                 335     


Val Ile Ala Ser Tyr Asn Gln Leu Ser Ser Phe Arg Gln Pro Lys Val 
            340                 345                 350         


Val Arg Tyr Arg Val Val Asn Leu Tyr Glu Asp Asp His Lys Asn Pro 
        355                 360                 365             


Thr Val Thr Arg Glu Gln Val Asp Phe Gln His His Gln Leu Ala Glu 
    370                 375                 380                 


Ala Phe Lys Gln Tyr Asn Ile Ser Trp Glu Leu Asp Val Leu Glu Val 
385                 390                 395                 400 


Ser Asn Ser Ser Leu Arg Arg Arg Leu Ile Leu Ala Asn Cys Asp Ile 
                405                 410                 415     


Ser Lys Ile Gly Asp Glu Asn Cys Asp Pro Glu Cys Asn His Thr Leu 
            420                 425                 430         


Thr Gly His Asp Gly Gly Asp Cys Arg His Leu Arg His Pro Ala Phe 
        435                 440                 445             


Val Lys Lys Gln His Asn Gly Val Cys Asp Met Asp Cys Asn Tyr Glu 
    450                 455                 460                 


Arg Phe Asn Phe Asp Gly Gly Glu Cys Cys Asp Pro Glu Ile Thr Asn 
465                 470                 475                 480 


Val Thr Gln Thr Cys Phe Asp Pro Asp Ser Pro His Arg Ala Tyr Leu 
                485                 490                 495     


Asp Val Asn Glu Leu Lys Asn Ile Leu Lys Leu Asp Gly Ser Thr His 
            500                 505                 510         


Leu Asn Ile Phe Phe Ala Lys Ser Ser Glu Glu Glu Leu Ala Gly Val 
        515                 520                 525             


Ala Thr Trp Pro Trp Asp Lys Glu Ala Leu Met His Leu Gly Gly Ile 
    530                 535                 540                 


Val Leu Asn Pro Ser Phe Tyr Gly Met Pro Gly His Thr His Thr Met 
545                 550                 555                 560 


Ile His Glu Ile Gly His Ser Leu Gly Leu Tyr His Val Phe Arg Gly 
                565                 570                 575     


Ile Ser Glu Ile Gln Ser Cys Ser Asp Pro Cys Met Glu Thr Glu Pro 
            580                 585                 590         


Ser Phe Glu Thr Gly Asp Leu Cys Asn Asp Thr Asn Pro Ala Pro Lys 
        595                 600                 605             


His Lys Ser Cys Gly Asp Pro Gly Pro Gly Asn Asp Thr Cys Gly Phe 
    610                 615                 620                 


His Ser Phe Phe Asn Thr Pro Tyr Asn Asn Phe Met Ser Tyr Ala Asp 
625                 630                 635                 640 


Asp Asp Cys Thr Asp Ser Phe Thr Pro Asn Gln Val Ala Arg Met His 
                645                 650                 655     


Cys Tyr Leu Asp Leu Val Tyr Gln Gly Trp Gln Pro Ser Arg Lys Pro 
            660                 665                 670         


Ala Pro Val Ala Leu Ala Pro Gln Val Leu Gly His Thr Thr Asp Ser 
        675                 680                 685             


Val Thr Leu Glu Trp Phe Pro Pro Ile Asp Gly His Phe Phe Glu Arg 
    690                 695                 700                 


Glu Leu Gly Ser Ala Cys His Leu Cys Leu Glu Gly Arg Ile Leu Val 
705                 710                 715                 720 


Gln Tyr Ala Ser Asn Ala Ser Ser Pro Met Pro Cys Ser Pro Ser Gly 
                725                 730                 735     


His Trp Ser Pro Arg Glu Ala Glu Gly His Pro Asp Val Glu Gln Pro 
            740                 745                 750         


Cys Lys Ser Ser Val Arg Thr Trp Ser Pro Asn Ser Ala Val Asn Pro 
        755                 760                 765             


His Thr Val Pro Pro Ala Cys Pro Glu Pro Gln Gly Cys Tyr Leu Glu 
    770                 775                 780                 


Leu Glu Phe Leu Tyr Pro Leu Val Pro Glu Ser Leu Thr Ile Trp Val 
785                 790                 795                 800 


Thr Phe Val Ser Thr Asp Trp Asp Ser Ser Gly Ala Val Asn Asp Ile 
                805                 810                 815     


Lys Leu Leu Ala Val Ser Gly Lys Asn Ile Ser Leu Gly Pro Gln Asn 
            820                 825                 830         


Val Phe Cys Asp Val Pro Leu Thr Ile Arg Leu Trp Asp Val Gly Glu 
        835                 840                 845             


Glu Val Tyr Gly Ile Gln Ile Tyr Thr Leu Asp Glu His Leu Glu Ile 
    850                 855                 860                 


Asp Ala Ala Met Leu Thr Ser Thr Ala Asp Thr Pro Leu Cys Leu Gln 
865                 870                 875                 880 


Cys Lys Pro Leu Lys Tyr Lys Val Val Arg Asp Pro Pro Leu Gln Met 
                885                 890                 895     


Asp Val Ala Ser Ile Leu His Leu Asn Arg Lys Phe Val Asp Met Asp 
            900                 905                 910         


Leu Asn Leu Gly Ser Val Tyr Gln Tyr Trp Val Ile Thr Ile Ser Gly 
        915                 920                 925             


Thr Glu Glu Ser Glu Pro Ser Pro Ala Val Thr Tyr Ile His Gly Ser 
    930                 935                 940                 


Gly Tyr Cys Gly Asp Gly Ile Ile Gln Lys Asp Gln Gly Glu Gln Cys 
945                 950                 955                 960 


Asp Asp Met Asn Lys Ile Asn Gly Asp Gly Cys Ser Leu Phe Cys Arg 
                965                 970                 975     


Gln Glu Val Ser Phe Asn Cys Ile Asp Glu Pro Ser Arg Cys Tyr Phe 
            980                 985                 990         


His Asp Gly Asp Gly Val Cys Glu  Glu Phe Glu Gln Lys  Thr Ser Ile 
        995                 1000                 1005             


Lys Asp  Cys Gly Val Tyr Thr  Pro Gln Gly Phe Leu  Asp Gln Trp 
    1010                 1015                 1020             


Ala Ser  Asn Ala Ser Val Ser  His Gln Asp Gln Gln  Cys Pro Gly 
    1025                 1030                 1035             


Trp Val  Ile Ile Gly Gln Pro  Ala Ala Ser Gln Val  Cys Arg Thr 
    1040                 1045                 1050             


Lys Val  Ile Asp Leu Ser Glu  Gly Ile Ser Gln His  Ala Trp Tyr 
    1055                 1060                 1065             


Pro Cys  Thr Ile Ser Tyr Pro  Tyr Ser Gln Leu Ala  Gln Thr Thr 
    1070                 1075                 1080             


Phe Trp  Leu Arg Ala Tyr Phe  Ser Gln Pro Met Val  Ala Ala Ala 
    1085                 1090                 1095             


Val Ile  Val His Leu Val Thr  Asp Gly Thr Tyr Tyr  Gly Asp Gln 
    1100                 1105                 1110             


Lys Gln  Glu Thr Ile Ser Val  Gln Leu Leu Asp Thr  Lys Asp Gln 
    1115                 1120                 1125             


Ser His  Asp Leu Gly Leu His  Val Leu Ser Cys Arg  Asn Asn Pro 
    1130                 1135                 1140             


Leu Ile  Ile Pro Val Val His  Asp Leu Ser Gln Pro  Phe Tyr His 
    1145                 1150                 1155             


Ser Gln  Ala Val Arg Val Ser  Phe Ser Ser Pro Leu  Val Ala Ile 
    1160                 1165                 1170             


Ser Gly  Val Ala Leu Arg Ser  Phe Asp Asn Phe Asp  Pro Val Thr 
    1175                 1180                 1185             


Leu Ser  Ser Cys Gln Arg Gly  Glu Thr Tyr Ser Pro  Ala Glu Gln 
    1190                 1195                 1200             


Ser Cys  Val His Phe Ala Cys  Glu Lys Thr Asp Cys  Pro Glu Leu 
    1205                 1210                 1215             


Ala Val  Glu Asn Ala Ser Leu  Asn Cys Ser Ser Ser  Asp Arg Tyr 
    1220                 1225                 1230             


His Gly  Ala Gln Cys Thr Val  Ser Cys Arg Thr Gly  Tyr Val Leu 
    1235                 1240                 1245             


Gln Ile  Arg Arg Asp Asp Glu  Leu Ile Lys Ser Gln  Thr Gly Pro 
    1250                 1255                 1260             


Ser Val  Thr Val Thr Cys Thr  Glu Gly Lys Trp Asn  Lys Gln Val 
    1265                 1270                 1275             


Ala Cys  Glu Pro Val Asp Cys  Ser Ile Pro Asp His  His Gln Val 
    1280                 1285                 1290             


Tyr Ala  Ala Ser Phe Ser Cys  Pro Glu Gly Thr Thr  Phe Gly Ser 
    1295                 1300                 1305             


Gln Cys  Ser Phe Gln Cys Arg  His Pro Ala Gln Leu  Lys Gly Asn 
    1310                 1315                 1320             


Asn Ser  Leu Leu Thr Cys Met  Glu Asp Gly Leu Trp  Ser Phe Pro 
    1325                 1330                 1335             


Glu Ala  Leu Cys Glu Leu Met  Cys Leu Ala Pro Pro  Pro Val Pro 
    1340                 1345                 1350             


Asn Ala  Asp Leu Gln Thr Ala  Arg Cys Arg Glu Asn  Lys His Lys 
    1355                 1360                 1365             


Val Gly  Ser Phe Cys Lys Tyr  Lys Cys Lys Pro Gly  Tyr His Val 
    1370                 1375                 1380             


Pro Gly  Ser Ser Arg Lys Ser  Lys Lys Arg Ala Phe  Lys Thr Gln 
    1385                 1390                 1395             


Cys Thr  Gln Asp Gly Ser Trp  Gln Glu Gly Ala Cys  Val Pro Val 
    1400                 1405                 1410             


Thr Cys  Asp Pro Pro Pro Pro  Lys Phe His Gly Leu  Tyr Gln Cys 
    1415                 1420                 1425             


Thr Asn  Gly Phe Gln Phe Asn  Ser Glu Cys Arg Ile  Lys Cys Glu 
    1430                 1435                 1440             


Asp Ser  Asp Ala Ser Gln Gly  Leu Gly Ser Asn Val  Ile His Cys 
    1445                 1450                 1455             


Arg Lys  Asp Gly Thr Trp Asn  Gly Ser Phe His Val  Cys Gln Glu 
    1460                 1465                 1470             


Met Gln  Gly Gln Cys Ser Val  Pro Asn Glu Leu Asn  Ser Asn Leu 
    1475                 1480                 1485             


Lys Leu  Gln Cys Pro Asp Gly  Tyr Ala Ile Gly Ser  Glu Cys Ala 
    1490                 1495                 1500             


Thr Ser  Cys Leu Asp His Asn  Ser Glu Ser Ile Ile  Leu Pro Met 
    1505                 1510                 1515             


Asn Val  Thr Val Arg Asp Ile  Pro His Trp Leu Asn  Pro Thr Arg 
    1520                 1525                 1530             


Val Glu  Arg Val Val Cys Thr  Ala Gly Leu Lys Trp  Tyr Pro His 
    1535                 1540                 1545             


Pro Ala  Leu Ile His Cys Val  Lys Gly Cys Glu Pro  Phe Met Gly 
    1550                 1555                 1560             


Asp Asn  Tyr Cys Asp Ala Ile  Asn Asn Arg Ala Phe  Cys Asn Tyr 
    1565                 1570                 1575             


Asp Gly  Gly Asp Cys Cys Thr  Ser Thr Val Lys Thr  Lys Lys Val 
    1580                 1585                 1590             


Thr Pro  Phe Pro Met Ser Cys  Asp Leu Gln Gly Asp  Cys Ala Cys 
    1595                 1600                 1605             


Arg Asp  Pro Gln Ala Gln Glu  His Ser Arg Lys Asp  Leu Arg Gly 
    1610                 1615                 1620             


Tyr Ser  His Gly 
    1625         


<210>  9993
<211>  827
<212>  PRT
<213>  Homo Sapiens

<400>  9993

Met Met Cys Leu Lys Ile Leu Arg Ile Ser Leu Ala Ile Leu Ala Gly 
1               5                   10                  15      


Trp Ala Leu Cys Ser Ala Asn Ser Glu Leu Gly Trp Thr Arg Lys Lys 
            20                  25                  30          


Ser Leu Val Glu Arg Glu His Leu Asn Gln Val Leu Leu Glu Gly Glu 
        35                  40                  45              


Arg Cys Trp Leu Gly Ala Lys Val Arg Arg Pro Arg Ala Ser Pro Gln 
    50                  55                  60                  


His His Leu Phe Gly Val Tyr Pro Ser Arg Ala Gly Asn Tyr Leu Arg 
65                  70                  75                  80  


Pro Tyr Pro Val Gly Glu Gln Glu Ile His His Thr Gly Arg Ser Lys 
                85                  90                  95      


Pro Asp Thr Glu Gly Asn Ala Val Ser Leu Val Pro Pro Asp Leu Thr 
            100                 105                 110         


Glu Asn Pro Ala Gly Leu Arg Gly Ala Val Glu Glu Pro Ala Ala Pro 
        115                 120                 125             


Trp Val Gly Asp Ser Pro Ile Gly Gln Ser Glu Leu Leu Gly Asp Asp 
    130                 135                 140                 


Asp Ala Tyr Leu Gly Asn Gln Arg Ser Lys Glu Ser Leu Gly Glu Ala 
145                 150                 155                 160 


Gly Ile Gln Lys Gly Ser Ala Met Ala Ala Thr Thr Thr Thr Ala Ile 
                165                 170                 175     


Phe Thr Thr Leu Asn Glu Pro Lys Pro Glu Thr Gln Arg Arg Gly Trp 
            180                 185                 190         


Ala Lys Ser Arg Gln Arg Arg Gln Val Trp Lys Arg Arg Ala Glu Asp 
        195                 200                 205             


Gly Gln Gly Asp Ser Gly Ile Ser Ser His Phe Gln Pro Trp Pro Lys 
    210                 215                 220                 


His Ser Leu Lys His Arg Val Lys Lys Ser Pro Pro Glu Glu Ser Asn 
225                 230                 235                 240 


Gln Asn Gly Gly Glu Gly Ser Tyr Arg Glu Ala Glu Thr Phe Asn Ser 
                245                 250                 255     


Gln Val Gly Leu Pro Ile Leu Tyr Phe Ser Gly Arg Arg Glu Arg Leu 
            260                 265                 270         


Leu Leu Arg Pro Glu Val Leu Ala Glu Ile Pro Arg Glu Ala Phe Thr 
        275                 280                 285             


Val Glu Ala Trp Val Lys Pro Glu Gly Gly Gln Asn Asn Pro Ala Ile 
    290                 295                 300                 


Ile Ala Gly Val Phe Asp Asn Cys Ser His Thr Val Ser Asp Lys Gly 
305                 310                 315                 320 


Trp Ala Leu Gly Ile Arg Ser Gly Lys Asp Lys Gly Lys Arg Asp Ala 
                325                 330                 335     


Arg Phe Phe Phe Ser Leu Cys Thr Asp Arg Val Lys Lys Ala Thr Ile 
            340                 345                 350         


Leu Ile Ser His Ser Arg Tyr Gln Pro Gly Thr Trp Thr His Val Ala 
        355                 360                 365             


Ala Thr Tyr Asp Gly Arg His Met Ala Leu Tyr Val Asp Gly Thr Gln 
    370                 375                 380                 


Val Ala Ser Ser Leu Asp Gln Ser Gly Pro Leu Asn Ser Pro Phe Met 
385                 390                 395                 400 


Ala Ser Cys Arg Ser Leu Leu Leu Gly Gly Asp Ser Ser Glu Asp Gly 
                405                 410                 415     


His Tyr Phe Arg Gly His Leu Gly Thr Leu Val Phe Trp Ser Thr Ala 
            420                 425                 430         


Leu Pro Gln Ser His Phe Gln His Ser Ser Gln His Ser Ser Gly Glu 
        435                 440                 445             


Glu Glu Ala Thr Asp Leu Val Leu Thr Ala Ser Phe Glu Pro Val Asn 
    450                 455                 460                 


Thr Glu Trp Val Pro Phe Arg Asp Glu Lys Tyr Pro Arg Leu Glu Val 
465                 470                 475                 480 


Leu Gln Gly Phe Glu Pro Glu Pro Glu Ile Leu Ser Pro Leu Gln Pro 
                485                 490                 495     


Pro Leu Cys Gly Gln Thr Val Cys Asp Asn Val Glu Leu Ile Ser Gln 
            500                 505                 510         


Tyr Asn Gly Tyr Trp Pro Leu Arg Gly Glu Lys Val Ile Arg Tyr Gln 
        515                 520                 525             


Val Val Asn Ile Cys Asp Asp Glu Gly Leu Asn Pro Ile Val Ser Glu 
    530                 535                 540                 


Glu Gln Ile Arg Leu Gln His Glu Ala Leu Asn Glu Ala Phe Ser Arg 
545                 550                 555                 560 


Tyr Asn Ile Ser Trp Gln Leu Ser Val His Gln Val His Asn Ser Thr 
                565                 570                 575     


Leu Arg His Arg Val Val Leu Val Asn Cys Glu Pro Ser Lys Ile Gly 
            580                 585                 590         


Asn Asp His Cys Asp Pro Glu Cys Glu His Pro Leu Thr Gly Tyr Asp 
        595                 600                 605             


Gly Gly Asp Cys Arg Leu Gln Gly Arg Cys Tyr Ser Trp Asn Arg Arg 
    610                 615                 620                 


Asp Gly Leu Cys His Val Glu Cys Asn Asn Met Leu Asn Asp Phe Asp 
625                 630                 635                 640 


Asp Gly Asp Cys Cys Asp Pro Gln Val Ala Asp Val Arg Lys Thr Cys 
                645                 650                 655     


Phe Asp Pro Asp Ser Pro Lys Arg Ala Tyr Met Ser Val Lys Glu Leu 
            660                 665                 670         


Lys Glu Ala Leu Gln Leu Asn Ser Thr His Phe Leu Asn Ile Tyr Phe 
        675                 680                 685             


Ala Ser Ser Val Arg Glu Asp Leu Ala Gly Ala Ala Thr Trp Pro Trp 
    690                 695                 700                 


Asp Lys Asp Ala Val Thr His Leu Gly Gly Ile Val Leu Ser Pro Ala 
705                 710                 715                 720 


Tyr Tyr Gly Met Pro Gly His Thr Asp Thr Met Ile His Glu Val Gly 
                725                 730                 735     


His Val Leu Gly Leu Tyr His Val Phe Lys Gly Val Ser Glu Arg Glu 
            740                 745                 750         


Ser Cys Asn Asp Pro Cys Lys Glu Thr Val Pro Ser Met Glu Thr Gly 
        755                 760                 765             


Asp Leu Cys Ala Asp Thr Ala Pro Thr Pro Lys Ser Glu Leu Cys Arg 
    770                 775                 780                 


Glu Pro Glu Pro Thr Ser Asp Thr Cys Gly Phe Thr Arg Phe Pro Gly 
785                 790                 795                 800 


Ala Pro Phe Thr Asn Tyr Met Ser Tyr Thr Gly Ile Thr Thr Val Leu 
                805                 810                 815     


Phe Cys Phe Leu Leu Arg Ile His Gly Gly Leu 
            820                 825         


<210>  9994
<211>  1791
<212>  PRT
<213>  Homo Sapiens

<400>  9994

Met Met Cys Leu Lys Ile Leu Arg Ile Ser Leu Ala Ile Leu Ala Gly 
1               5                   10                  15      


Trp Ala Leu Cys Ser Ala Asn Ser Glu Leu Gly Trp Thr Arg Lys Lys 
            20                  25                  30          


Ser Leu Val Glu Arg Glu His Leu Asn Gln Val Leu Leu Glu Gly Glu 
        35                  40                  45              


Arg Cys Trp Leu Gly Ala Lys Val Arg Arg Pro Arg Ala Ser Pro Gln 
    50                  55                  60                  


His His Leu Phe Gly Val Tyr Pro Ser Arg Ala Gly Asn Tyr Leu Arg 
65                  70                  75                  80  


Pro Tyr Pro Val Gly Glu Gln Glu Ile His His Thr Gly Arg Ser Lys 
                85                  90                  95      


Pro Asp Thr Glu Gly Asn Ala Val Ser Leu Val Pro Pro Asp Leu Thr 
            100                 105                 110         


Glu Asn Pro Ala Gly Leu Arg Gly Ala Val Glu Glu Pro Ala Ala Pro 
        115                 120                 125             


Trp Val Gly Asp Ser Pro Ile Gly Gln Ser Glu Leu Leu Gly Asp Asp 
    130                 135                 140                 


Asp Ala Tyr Leu Gly Asn Gln Arg Ser Lys Glu Ser Leu Gly Glu Ala 
145                 150                 155                 160 


Gly Ile Gln Lys Gly Ser Ala Met Ala Ala Thr Thr Thr Thr Ala Ile 
                165                 170                 175     


Phe Thr Thr Leu Asn Glu Pro Lys Pro Glu Thr Gln Arg Arg Gly Trp 
            180                 185                 190         


Ala Lys Ser Arg Gln Arg Arg Gln Val Trp Lys Arg Arg Ala Glu Asp 
        195                 200                 205             


Gly Gln Gly Asp Ser Gly Ile Ser Ser His Phe Gln Pro Trp Pro Lys 
    210                 215                 220                 


His Ser Leu Lys His Arg Val Lys Lys Ser Pro Pro Glu Glu Ser Asn 
225                 230                 235                 240 


Gln Asn Gly Gly Glu Gly Ser Tyr Arg Glu Ala Glu Thr Phe Asn Ser 
                245                 250                 255     


Gln Val Gly Leu Pro Ile Leu Tyr Phe Ser Gly Arg Arg Glu Arg Leu 
            260                 265                 270         


Leu Leu Arg Pro Glu Val Leu Ala Glu Ile Pro Arg Glu Ala Phe Thr 
        275                 280                 285             


Val Glu Ala Trp Val Lys Pro Glu Gly Gly Gln Asn Asn Pro Ala Ile 
    290                 295                 300                 


Ile Ala Gly Val Phe Asp Asn Cys Ser His Thr Val Ser Asp Lys Gly 
305                 310                 315                 320 


Trp Ala Leu Gly Ile Arg Ser Gly Lys Asp Lys Gly Lys Arg Asp Ala 
                325                 330                 335     


Arg Phe Phe Phe Ser Leu Cys Thr Asp Arg Val Lys Lys Ala Thr Ile 
            340                 345                 350         


Leu Ile Ser His Ser Arg Tyr Gln Pro Gly Thr Trp Thr His Val Ala 
        355                 360                 365             


Ala Thr Tyr Asp Gly Arg His Met Ala Leu Tyr Val Asp Gly Thr Gln 
    370                 375                 380                 


Val Ala Ser Ser Leu Asp Gln Ser Gly Pro Leu Asn Ser Pro Phe Met 
385                 390                 395                 400 


Ala Ser Cys Arg Ser Leu Leu Leu Gly Gly Asp Ser Ser Glu Asp Gly 
                405                 410                 415     


His Tyr Phe Arg Gly His Leu Gly Thr Leu Val Phe Trp Ser Thr Ala 
            420                 425                 430         


Leu Pro Gln Ser His Phe Gln His Ser Ser Gln His Ser Ser Gly Glu 
        435                 440                 445             


Glu Glu Ala Thr Asp Leu Val Leu Thr Ala Ser Phe Glu Pro Val Asn 
    450                 455                 460                 


Thr Glu Trp Val Pro Phe Arg Asp Glu Lys Tyr Pro Arg Leu Glu Val 
465                 470                 475                 480 


Leu Gln Gly Phe Glu Pro Glu Pro Glu Ile Leu Ser Pro Leu Gln Pro 
                485                 490                 495     


Pro Leu Cys Gly Gln Thr Val Cys Asp Asn Val Glu Leu Ile Ser Gln 
            500                 505                 510         


Tyr Asn Gly Tyr Trp Pro Leu Arg Gly Glu Lys Val Ile Arg Tyr Gln 
        515                 520                 525             


Val Val Asn Ile Cys Asp Asp Glu Gly Leu Asn Pro Ile Val Ser Glu 
    530                 535                 540                 


Glu Gln Ile Arg Leu Gln His Glu Ala Leu Asn Glu Ala Phe Ser Arg 
545                 550                 555                 560 


Tyr Asn Ile Ser Trp Gln Leu Ser Val His Gln Val His Asn Ser Thr 
                565                 570                 575     


Leu Arg His Arg Val Val Leu Val Asn Cys Glu Pro Ser Lys Ile Gly 
            580                 585                 590         


Asn Asp His Cys Asp Pro Glu Cys Glu His Pro Leu Thr Gly Tyr Asp 
        595                 600                 605             


Gly Gly Asp Cys Arg Leu Gln Gly Arg Cys Tyr Ser Trp Asn Arg Arg 
    610                 615                 620                 


Asp Gly Leu Cys His Val Glu Cys Asn Asn Met Leu Asn Asp Phe Asp 
625                 630                 635                 640 


Asp Gly Asp Cys Cys Asp Pro Gln Val Ala Asp Val Arg Lys Thr Cys 
                645                 650                 655     


Phe Asp Pro Asp Ser Pro Lys Arg Ala Tyr Met Ser Val Lys Glu Leu 
            660                 665                 670         


Lys Glu Ala Leu Gln Leu Asn Ser Thr His Phe Leu Asn Ile Tyr Phe 
        675                 680                 685             


Ala Ser Ser Val Arg Glu Asp Leu Ala Gly Ala Ala Thr Trp Pro Trp 
    690                 695                 700                 


Asp Lys Asp Ala Val Thr His Leu Gly Gly Ile Val Leu Ser Pro Ala 
705                 710                 715                 720 


Tyr Tyr Gly Met Pro Gly His Thr Asp Thr Met Ile His Glu Val Gly 
                725                 730                 735     


His Val Leu Gly Leu Tyr His Val Phe Lys Gly Val Ser Glu Arg Glu 
            740                 745                 750         


Ser Cys Asn Asp Pro Cys Lys Glu Thr Val Pro Ser Met Glu Thr Gly 
        755                 760                 765             


Asp Leu Cys Ala Asp Thr Ala Pro Thr Pro Lys Ser Glu Leu Cys Arg 
    770                 775                 780                 


Glu Pro Glu Pro Thr Ser Asp Thr Cys Gly Phe Thr Arg Phe Pro Gly 
785                 790                 795                 800 


Ala Pro Phe Thr Asn Tyr Met Ser Tyr Thr Asp Asp Asn Cys Thr Asp 
                805                 810                 815     


Asn Phe Thr Pro Asn Gln Val Ala Arg Met His Cys Tyr Leu Asp Leu 
            820                 825                 830         


Val Tyr Gln Gln Trp Thr Glu Ser Arg Lys Pro Thr Pro Ile Pro Ile 
        835                 840                 845             


Pro Pro Met Val Ile Gly Gln Thr Asn Lys Ser Leu Thr Ile His Trp 
    850                 855                 860                 


Leu Pro Pro Ile Ser Gly Val Val Tyr Asp Arg Ala Ser Gly Ser Leu 
865                 870                 875                 880 


Cys Gly Ala Cys Thr Glu Asp Gly Thr Phe Arg Gln Tyr Val His Thr 
                885                 890                 895     


Ala Ser Ser Arg Arg Val Cys Asp Ser Ser Gly Tyr Trp Thr Pro Glu 
            900                 905                 910         


Glu Ala Val Gly Pro Pro Asp Val Asp Gln Pro Cys Glu Pro Ser Leu 
        915                 920                 925             


Gln Ala Trp Ser Pro Glu Val His Leu Tyr His Met Asn Met Thr Val 
    930                 935                 940                 


Pro Cys Pro Thr Glu Gly Cys Ser Leu Glu Leu Leu Phe Gln His Pro 
945                 950                 955                 960 


Val Gln Ala Asp Thr Leu Thr Leu Trp Val Thr Ser Phe Phe Met Glu 
                965                 970                 975     


Ser Ser Gln Val Leu Phe Asp Thr Glu Ile Leu Leu Glu Asn Lys Glu 
            980                 985                 990         


Ser Val His Leu Gly Pro Leu Asp  Thr Phe Cys Asp Ile  Pro Leu Thr 
        995                 1000                 1005             


Ile Lys  Leu His Val Asp Gly  Lys Val Ser Gly Val  Lys Val Tyr 
    1010                 1015                 1020             


Thr Phe  Asp Glu Arg Ile Glu  Ile Asp Ala Ala Leu  Leu Thr Ser 
    1025                 1030                 1035             


Gln Pro  His Ser Pro Leu Cys  Ser Gly Cys Arg Pro  Val Arg Tyr 
    1040                 1045                 1050             


Gln Val  Leu Arg Asp Pro Pro  Phe Ala Ser Gly Leu  Pro Val Val 
    1055                 1060                 1065             


Val Thr  His Ser His Arg Lys  Phe Thr Asp Val Glu  Val Thr Pro 
    1070                 1075                 1080             


Gly Gln  Met Tyr Gln Tyr Gln  Val Leu Ala Glu Ala  Gly Gly Glu 
    1085                 1090                 1095             


Leu Gly  Glu Ala Ser Pro Pro  Leu Asn His Ile His  Gly Ala Pro 
    1100                 1105                 1110             


Tyr Cys  Gly Asp Gly Lys Val  Ser Glu Arg Leu Gly  Glu Glu Cys 
    1115                 1120                 1125             


Asp Asp  Gly Asp Leu Val Ser  Gly Asp Gly Cys Ser  Lys Val Cys 
    1130                 1135                 1140             


Glu Leu  Glu Glu Gly Phe Asn  Cys Val Gly Glu Pro  Ser Leu Cys 
    1145                 1150                 1155             


Tyr Met  Tyr Glu Gly Asp Gly  Ile Cys Glu Pro Phe  Glu Arg Lys 
    1160                 1165                 1170             


Thr Ser  Ile Val Asp Cys Gly  Ile Tyr Thr Pro Lys  Gly Tyr Leu 
    1175                 1180                 1185             


Asp Gln  Trp Ala Thr Arg Ala  Tyr Ser Ser His Glu  Asp Lys Lys 
    1190                 1195                 1200             


Lys Cys  Pro Val Ser Leu Val  Thr Gly Glu Pro His  Ser Leu Ile 
    1205                 1210                 1215             


Cys Thr  Ser Tyr His Pro Asp  Leu Pro Asn His Arg  Pro Leu Thr 
    1220                 1225                 1230             


Gly Trp  Phe Pro Cys Val Ala  Ser Glu Asn Glu Thr  Gln Asp Asp 
    1235                 1240                 1245             


Arg Ser  Glu Gln Pro Glu Gly  Ser Leu Lys Lys Glu  Asp Glu Val 
    1250                 1255                 1260             


Trp Leu  Lys Val Cys Phe Asn  Arg Pro Gly Glu Ala  Arg Ala Ile 
    1265                 1270                 1275             


Phe Ile  Phe Leu Thr Thr Asp  Gly Leu Val Pro Gly  Glu His Gln 
    1280                 1285                 1290             


Gln Pro  Thr Val Thr Leu Tyr  Leu Thr Asp Val Arg  Gly Ser Asn 
    1295                 1300                 1305             


His Ser  Leu Gly Thr Tyr Gly  Leu Ser Cys Gln His  Asn Pro Leu 
    1310                 1315                 1320             


Ile Ile  Asn Val Thr His His  Gln Asn Val Leu Phe  His His Thr 
    1325                 1330                 1335             


Thr Ser  Val Leu Leu Asn Phe  Ser Ser Pro Arg Val  Gly Ile Ser 
    1340                 1345                 1350             


Ala Val  Ala Leu Arg Thr Ser  Ser Arg Ile Gly Leu  Ser Ala Pro 
    1355                 1360                 1365             


Ser Asn  Cys Ile Ser Glu Asp  Glu Gly Gln Asn His  Gln Gly Gln 
    1370                 1375                 1380             


Ser Cys  Ile His Arg Pro Cys  Gly Lys Gln Asp Ser  Cys Pro Ser 
    1385                 1390                 1395             


Leu Leu  Leu Asp His Ala Asp  Val Val Asn Cys Thr  Ser Ile Gly 
    1400                 1405                 1410             


Pro Gly  Leu Met Lys Cys Ala  Ile Thr Cys Gln Arg  Gly Phe Ala 
    1415                 1420                 1425             


Leu Gln  Ala Ser Ser Gly Gln  Tyr Ile Arg Pro Met  Gln Lys Glu 
    1430                 1435                 1440             


Ile Leu  Leu Thr Cys Ser Ser  Gly His Trp Asp Gln  Asn Val Ser 
    1445                 1450                 1455             


Cys Leu  Pro Val Asp Cys Gly  Val Pro Asp Pro Ser  Leu Val Asn 
    1460                 1465                 1470             


Tyr Ala  Asn Phe Ser Cys Ser  Glu Gly Thr Lys Phe  Leu Lys Arg 
    1475                 1480                 1485             


Cys Ser  Ile Ser Cys Val Pro  Pro Ala Lys Leu Gln  Gly Leu Ser 
    1490                 1495                 1500             


Pro Trp  Leu Thr Cys Leu Glu  Asp Gly Leu Trp Ser  Leu Pro Glu 
    1505                 1510                 1515             


Val Tyr  Cys Lys Leu Glu Cys  Asp Ala Pro Pro Ile  Ile Leu Asn 
    1520                 1525                 1530             


Ala Asn  Leu Leu Leu Pro His  Cys Leu Gln Asp Asn  His Asp Val 
    1535                 1540                 1545             


Gly Thr  Ile Cys Lys Tyr Glu  Cys Lys Pro Gly Tyr  Tyr Val Ala 
    1550                 1555                 1560             


Glu Ser  Ala Glu Gly Lys Val  Arg Asn Lys Leu Leu  Lys Ile Gln 
    1565                 1570                 1575             


Cys Leu  Glu Gly Gly Ile Trp  Glu Gln Gly Ser Cys  Ile Pro Val 
    1580                 1585                 1590             


Val Cys  Glu Pro Pro Pro Pro  Val Phe Glu Gly Met  Tyr Glu Cys 
    1595                 1600                 1605             


Thr Asn  Gly Phe Ser Leu Asp  Ser Gln Cys Val Leu  Asn Cys Asn 
    1610                 1615                 1620             


Gln Glu  Arg Glu Lys Leu Pro  Ile Leu Cys Thr Lys  Glu Gly Leu 
    1625                 1630                 1635             


Trp Thr  Gln Glu Phe Lys Leu  Cys Glu Asn Leu Gln  Gly Glu Cys 
    1640                 1645                 1650             


Pro Pro  Pro Pro Ser Glu Leu  Asn Ser Val Glu Tyr  Lys Cys Glu 
    1655                 1660                 1665             


Gln Gly  Tyr Gly Ile Gly Ala  Val Cys Ser Pro Leu  Cys Val Ile 
    1670                 1675                 1680             


Pro Pro  Ser Asp Pro Val Met  Leu Pro Glu Asn Ile  Thr Ala Asp 
    1685                 1690                 1695             


Thr Leu  Glu His Trp Met Glu  Pro Val Lys Val Gln  Ser Ile Val 
    1700                 1705                 1710             


Cys Thr  Gly Arg Arg Gln Trp  His Pro Asp Pro Val  Leu Val His 
    1715                 1720                 1725             


Cys Ile  Gln Ser Cys Glu Pro  Phe Gln Ala Asp Gly  Trp Cys Asp 
    1730                 1735                 1740             


Thr Ile  Asn Asn Arg Ala Tyr  Cys His Tyr Asp Gly  Gly Asp Cys 
    1745                 1750                 1755             


Cys Ser  Ser Thr Leu Ser Ser  Lys Lys Val Ile Pro  Phe Ala Ala 
    1760                 1765                 1770             


Asp Cys  Asp Leu Asp Glu Cys  Thr Cys Arg Asp Pro  Lys Ala Glu 
    1775                 1780                 1785             


Glu Asn  Gln 
    1790     


<210>  9995
<211>  678
<212>  PRT
<213>  Homo Sapiens

<400>  9995

Met Ala Ala Pro Gly Pro Leu Pro Ala Ala Ala Leu Ser Pro Gly Ala 
1               5                   10                  15      


Pro Thr Pro Arg Glu Leu Met His Gly Val Ala Gly Val Thr Ser Arg 
            20                  25                  30          


Ala Gly Arg Asp Arg Glu Ala Gly Ser Val Leu Pro Ala Gly Asn Arg 
        35                  40                  45              


Gly Ala Arg Lys Ala Ser Arg Arg Ser Ser Ser Arg Ser Met Ser Arg 
    50                  55                  60                  


Asp Asn Lys Phe Ser Lys Lys Asp Cys Leu Ser Ile Arg Asn Val Val 
65                  70                  75                  80  


Ala Ser Ile Gln Thr Lys Glu Gly Leu Asn Leu Lys Leu Ile Ser Gly 
                85                  90                  95      


Asp Val Leu Tyr Ile Trp Ala Asp Val Ile Val Asn Ser Val Pro Met 
            100                 105                 110         


Asn Leu Gln Leu Gly Gly Gly Pro Leu Ser Arg Ala Phe Leu Gln Lys 
        115                 120                 125             


Ala Gly Pro Met Leu Gln Lys Glu Leu Asp Asp Arg Arg Arg Glu Thr 
    130                 135                 140                 


Glu Glu Lys Val Gly Asn Ile Phe Met Thr Ser Gly Cys Asn Leu Asp 
145                 150                 155                 160 


Cys Lys Ala Val Leu His Ala Val Ala Pro Tyr Trp Asn Asn Gly Ala 
                165                 170                 175     


Glu Thr Ser Trp Gln Ile Met Ala Asn Ile Ile Lys Lys Cys Leu Thr 
            180                 185                 190         


Thr Val Glu Val Leu Ser Phe Ser Ser Ile Thr Phe Pro Met Ile Gly 
        195                 200                 205             


Thr Gly Ser Leu Gln Phe Pro Lys Ala Val Phe Ala Lys Leu Ile Leu 
    210                 215                 220                 


Ser Glu Val Phe Glu Tyr Ser Ser Ser Thr Arg Pro Ile Thr Ser Pro 
225                 230                 235                 240 


Leu Gln Glu Val His Phe Leu Val Tyr Thr Asn Asp Asp Glu Gly Cys 
                245                 250                 255     


Gln Ala Phe Leu Asp Glu Phe Thr Asn Trp Ser Arg Ile Asn Pro Asn 
            260                 265                 270         


Lys Ala Arg Ile Pro Met Ala Gly Asp Thr Gln Gly Val Val Gly Thr 
        275                 280                 285             


Val Ser Lys Pro Cys Phe Thr Ala Tyr Glu Met Lys Ile Gly Ala Ile 
    290                 295                 300                 


Thr Phe Gln Val Ala Thr Gly Asp Ile Ala Thr Glu Gln Val Asp Val 
305                 310                 315                 320 


Ile Val Asn Ser Thr Ala Arg Thr Phe Asn Arg Lys Ser Gly Val Ser 
                325                 330                 335     


Arg Ala Ile Leu Glu Gly Ala Gly Gln Ala Val Glu Ser Glu Cys Ala 
            340                 345                 350         


Val Leu Ala Ala Gln Pro His Arg Asp Phe Ile Ile Thr Pro Gly Gly 
        355                 360                 365             


Cys Leu Lys Cys Lys Ile Ile Ile His Val Pro Gly Gly Lys Asp Val 
    370                 375                 380                 


Arg Lys Thr Val Thr Ser Val Leu Glu Glu Cys Glu Gln Arg Lys Tyr 
385                 390                 395                 400 


Thr Ser Val Ser Leu Pro Ala Ile Gly Thr Gly Asn Ala Gly Lys Asn 
                405                 410                 415     


Pro Ile Thr Val Ala Asp Asn Ile Ile Asp Ala Ile Val Asp Phe Ser 
            420                 425                 430         


Ser Gln His Ser Thr Pro Ser Leu Lys Thr Val Lys Val Val Ile Phe 
        435                 440                 445             


Gln Pro Glu Leu Leu Asn Ile Phe Tyr Asp Ser Met Lys Lys Arg Asp 
    450                 455                 460                 


Leu Ser Ala Ser Leu Asn Phe Gln Ser Thr Phe Ser Met Thr Thr Cys 
465                 470                 475                 480 


Asn Leu Pro Glu His Trp Thr Asp Met Asn His Gln Leu Phe Cys Met 
                485                 490                 495     


Val Gln Leu Glu Pro Gly Gln Ser Glu Tyr Asn Thr Ile Lys Asp Lys 
            500                 505                 510         


Phe Thr Arg Thr Cys Ser Ser Tyr Ala Ile Glu Lys Ile Glu Arg Ile 
        515                 520                 525             


Gln Asn Ala Phe Leu Trp Gln Ser Tyr Gln Val Lys Lys Arg Gln Met 
    530                 535                 540                 


Asp Ile Lys Asn Asp His Lys Asn Asn Glu Arg Leu Leu Phe His Gly 
545                 550                 555                 560 


Thr Asp Ala Asp Ser Val Pro Tyr Val Asn Gln His Gly Phe Asn Arg 
                565                 570                 575     


Ser Cys Ala Gly Lys Asn Ala Val Ser Tyr Gly Lys Gly Thr Tyr Phe 
            580                 585                 590         


Ala Val Asp Ala Ser Tyr Ser Ala Lys Asp Thr Tyr Ser Lys Pro Asp 
        595                 600                 605             


Ser Asn Gly Arg Lys His Met Tyr Val Val Arg Val Leu Thr Gly Val 
    610                 615                 620                 


Phe Thr Lys Gly Arg Ala Gly Leu Val Thr Pro Pro Pro Lys Asn Pro 
625                 630                 635                 640 


His Asn Pro Thr Asp Leu Phe Asp Ser Val Thr Asn Asn Thr Arg Ser 
                645                 650                 655     


Pro Lys Leu Phe Val Val Phe Phe Asp Asn Gln Ala Tyr Pro Glu Tyr 
            660                 665                 670         


Leu Ile Thr Phe Thr Ala 
        675             


<210>  9996
<211>  483
<212>  PRT
<213>  Homo Sapiens

<400>  9996

Met Ala Ala Pro Gly Pro Leu Pro Ala Ala Ala Leu Ser Pro Gly Ala 
1               5                   10                  15      


Pro Thr Pro Arg Glu Leu Met His Gly Val Ala Gly Val Thr Ser Arg 
            20                  25                  30          


Ala Gly Arg Asp Arg Glu Ala Gly Ser Val Leu Pro Ala Gly Asn Arg 
        35                  40                  45              


Gly Ala Arg Lys Ala Ser Arg Arg Ser Ser Ser Arg Ser Met Ser Arg 
    50                  55                  60                  


Asp Asn Lys Phe Ser Lys Lys Asp Cys Leu Ser Ile Arg Asn Val Val 
65                  70                  75                  80  


Ala Ser Ile Gln Thr Lys Glu Gly Leu Asn Leu Lys Leu Ile Ser Gly 
                85                  90                  95      


Asp Val Leu Tyr Ile Trp Ala Asp Val Ile Val Asn Ser Val Pro Met 
            100                 105                 110         


Asn Leu Gln Leu Gly Gly Gly Pro Leu Ser Arg Ala Phe Leu Gln Lys 
        115                 120                 125             


Ala Gly Pro Met Leu Gln Lys Glu Leu Asp Asp Arg Arg Arg Glu Thr 
    130                 135                 140                 


Glu Glu Lys Val Gly Asn Ile Phe Met Thr Ser Gly Cys Asn Leu Asp 
145                 150                 155                 160 


Cys Lys Ala Val Leu His Ala Val Ala Pro Tyr Trp Asn Asn Gly Ala 
                165                 170                 175     


Glu Thr Ser Trp Gln Val Ala Thr Gly Asp Ile Ala Thr Glu Gln Val 
            180                 185                 190         


Asp Val Ile Val Asn Ser Thr Ala Arg Thr Phe Asn Arg Lys Ser Gly 
        195                 200                 205             


Val Ser Arg Ala Ile Leu Glu Gly Ala Gly Gln Ala Val Glu Ser Glu 
    210                 215                 220                 


Cys Ala Val Leu Ala Ala Gln Pro His Arg Asp Phe Ile Ile Thr Pro 
225                 230                 235                 240 


Gly Gly Cys Leu Lys Cys Lys Ile Ile Ile His Val Pro Gly Gly Lys 
                245                 250                 255     


Asp Val Arg Lys Thr Val Thr Ser Val Leu Glu Glu Cys Glu Gln Arg 
            260                 265                 270         


Lys Tyr Thr Ser Val Ser Leu Pro Ala Ile Gly Thr Gly Asn Leu Pro 
        275                 280                 285             


Glu His Trp Thr Asp Met Asn His Gln Leu Phe Cys Met Val Gln Leu 
    290                 295                 300                 


Glu Pro Gly Gln Ser Glu Tyr Asn Thr Ile Lys Asp Lys Phe Thr Arg 
305                 310                 315                 320 


Thr Cys Ser Ser Tyr Ala Ile Glu Lys Ile Glu Arg Ile Gln Asn Ala 
                325                 330                 335     


Phe Leu Trp Gln Ser Tyr Gln Val Lys Lys Arg Gln Met Asp Ile Lys 
            340                 345                 350         


Asn Asp His Lys Asn Asn Glu Arg Leu Leu Phe His Gly Thr Asp Ala 
        355                 360                 365             


Asp Ser Val Pro Tyr Val Asn Gln His Gly Phe Asn Arg Ser Cys Ala 
    370                 375                 380                 


Gly Lys Asn Ala Val Ser Tyr Gly Lys Gly Thr Tyr Phe Ala Val Asp 
385                 390                 395                 400 


Ala Ser Tyr Ser Ala Lys Asp Thr Tyr Ser Lys Pro Asp Ser Asn Gly 
                405                 410                 415     


Arg Lys His Met Tyr Val Val Arg Val Leu Thr Gly Val Phe Thr Lys 
            420                 425                 430         


Gly Arg Ala Gly Leu Val Thr Pro Pro Pro Lys Asn Pro His Asn Pro 
        435                 440                 445             


Thr Asp Leu Phe Asp Ser Val Thr Asn Asn Thr Arg Ser Pro Lys Leu 
    450                 455                 460                 


Phe Val Val Phe Phe Asp Asn Gln Ala Tyr Pro Glu Tyr Leu Ile Thr 
465                 470                 475                 480 


Phe Thr Ala 
            


<210>  9997
<211>  444
<212>  PRT
<213>  Homo Sapiens

<400>  9997

Met Leu Gln Arg Ile Gly Leu Ile Phe Leu His Asn Ile Val Val Val 
1               5                   10                  15      


Ser Asn Cys Phe Tyr Phe Gln Ala Phe Leu Asp Glu Phe Thr Asn Trp 
            20                  25                  30          


Ser Arg Ile Asn Pro Asn Lys Ala Arg Ile Pro Met Ala Gly Asp Thr 
        35                  40                  45              


Gln Gly Val Val Gly Thr Val Ser Lys Pro Cys Phe Thr Ala Tyr Glu 
    50                  55                  60                  


Met Lys Ile Gly Ala Ile Thr Phe Gln Val Ala Thr Gly Asp Ile Ala 
65                  70                  75                  80  


Thr Glu Gln Val Asp Val Ile Val Asn Ser Thr Ala Arg Thr Phe Asn 
                85                  90                  95      


Arg Lys Ser Gly Val Ser Arg Ala Ile Leu Glu Gly Ala Gly Gln Ala 
            100                 105                 110         


Val Glu Ser Glu Cys Ala Val Leu Ala Ala Gln Pro His Arg Asp Phe 
        115                 120                 125             


Ile Ile Thr Pro Gly Gly Cys Leu Lys Cys Lys Ile Ile Ile His Val 
    130                 135                 140                 


Pro Gly Gly Lys Asp Val Arg Lys Thr Val Thr Ser Val Leu Glu Glu 
145                 150                 155                 160 


Cys Glu Gln Arg Lys Tyr Thr Ser Val Ser Leu Pro Ala Ile Gly Thr 
                165                 170                 175     


Gly Asn Ala Gly Lys Asn Pro Ile Thr Val Ala Asp Asn Ile Ile Asp 
            180                 185                 190         


Ala Ile Val Asp Phe Ser Ser Gln His Ser Thr Pro Ser Leu Lys Thr 
        195                 200                 205             


Val Lys Val Val Ile Phe Gln Pro Glu Leu Leu Asn Ile Phe Tyr Asp 
    210                 215                 220                 


Ser Met Lys Lys Arg Asp Leu Ser Ala Ser Leu Asn Phe Gln Ser Thr 
225                 230                 235                 240 


Phe Ser Met Thr Thr Cys Asn Leu Pro Glu His Trp Thr Asp Met Asn 
                245                 250                 255     


His Gln Leu Phe Cys Met Val Gln Leu Glu Pro Gly Gln Ser Glu Tyr 
            260                 265                 270         


Asn Thr Ile Lys Asp Lys Phe Thr Arg Thr Cys Ser Ser Tyr Ala Ile 
        275                 280                 285             


Glu Lys Ile Glu Arg Ile Gln Asn Ala Phe Leu Trp Gln Ser Tyr Gln 
    290                 295                 300                 


Val Lys Lys Arg Gln Met Asp Ile Lys Asn Asp His Lys Asn Asn Glu 
305                 310                 315                 320 


Arg Leu Leu Phe His Gly Thr Asp Ala Asp Ser Val Pro Tyr Val Asn 
                325                 330                 335     


Gln His Gly Phe Asn Arg Ser Cys Ala Gly Lys Asn Ala Val Ser Tyr 
            340                 345                 350         


Gly Lys Gly Thr Tyr Phe Ala Val Asp Ala Ser Tyr Ser Ala Lys Asp 
        355                 360                 365             


Thr Tyr Ser Lys Pro Asp Ser Asn Gly Arg Lys His Met Tyr Val Val 
    370                 375                 380                 


Arg Val Leu Thr Gly Val Phe Thr Lys Gly Arg Ala Gly Leu Val Thr 
385                 390                 395                 400 


Pro Pro Pro Lys Asn Pro His Asn Pro Thr Asp Leu Phe Asp Ser Val 
                405                 410                 415     


Thr Asn Asn Thr Arg Ser Pro Lys Leu Phe Val Val Phe Phe Asp Asn 
            420                 425                 430         


Gln Ala Tyr Pro Glu Tyr Leu Ile Thr Phe Thr Ala 
        435                 440                 


<210>  9998
<211>  375
<212>  PRT
<213>  Homo Sapiens

<400>  9998

Met Leu Gln Arg Ile Gly Leu Ile Phe Leu His Asn Ile Val Val Val 
1               5                   10                  15      


Ser Asn Cys Phe Tyr Phe Gln Ala Phe Leu Asp Glu Phe Thr Asn Trp 
            20                  25                  30          


Ser Arg Ile Asn Pro Asn Lys Ala Arg Ile Pro Met Ala Gly Asp Thr 
        35                  40                  45              


Gln Gly Val Val Gly Thr Val Ser Lys Pro Cys Phe Thr Ala Tyr Glu 
    50                  55                  60                  


Met Lys Ile Gly Ala Ile Thr Phe Gln Val Ala Thr Gly Asp Ile Ala 
65                  70                  75                  80  


Thr Glu Gln Val Asp Val Ile Val Asn Ser Thr Ala Arg Thr Phe Asn 
                85                  90                  95      


Arg Lys Ser Gly Val Ser Arg Ala Ile Leu Glu Gly Ala Gly Gln Ala 
            100                 105                 110         


Val Glu Ser Glu Cys Ala Val Leu Ala Ala Gln Pro His Arg Asp Phe 
        115                 120                 125             


Ile Ile Thr Pro Gly Gly Cys Leu Lys Cys Lys Ile Ile Ile His Val 
    130                 135                 140                 


Pro Gly Gly Lys Asp Val Arg Lys Thr Val Thr Ser Val Leu Glu Glu 
145                 150                 155                 160 


Cys Glu Gln Arg Lys Tyr Thr Ser Val Ser Leu Pro Ala Ile Gly Thr 
                165                 170                 175     


Gly Asn Leu Pro Glu His Trp Thr Asp Met Asn His Gln Leu Phe Cys 
            180                 185                 190         


Met Val Gln Leu Glu Pro Gly Gln Ser Glu Tyr Asn Thr Ile Lys Asp 
        195                 200                 205             


Lys Phe Thr Arg Thr Cys Ser Ser Tyr Ala Ile Glu Lys Ile Glu Arg 
    210                 215                 220                 


Ile Gln Asn Ala Phe Leu Trp Gln Ser Tyr Gln Val Lys Lys Arg Gln 
225                 230                 235                 240 


Met Asp Ile Lys Asn Asp His Lys Asn Asn Glu Arg Leu Leu Phe His 
                245                 250                 255     


Gly Thr Asp Ala Asp Ser Val Pro Tyr Val Asn Gln His Gly Phe Asn 
            260                 265                 270         


Arg Ser Cys Ala Gly Lys Asn Ala Val Ser Tyr Gly Lys Gly Thr Tyr 
        275                 280                 285             


Phe Ala Val Asp Ala Ser Tyr Ser Ala Lys Asp Thr Tyr Ser Lys Pro 
    290                 295                 300                 


Asp Ser Asn Gly Arg Lys His Met Tyr Val Val Arg Val Leu Thr Gly 
305                 310                 315                 320 


Val Phe Thr Lys Gly Arg Ala Gly Leu Val Thr Pro Pro Pro Lys Asn 
                325                 330                 335     


Pro His Asn Pro Thr Asp Leu Phe Asp Ser Val Thr Asn Asn Thr Arg 
            340                 345                 350         


Ser Pro Lys Leu Phe Val Val Phe Phe Asp Asn Gln Ala Tyr Pro Glu 
        355                 360                 365             


Tyr Leu Ile Thr Phe Thr Ala 
    370                 375 


<210>  9999
<211>  397
<212>  PRT
<213>  Homo Sapiens

<400>  9999

Met His His Val Phe Lys Asp His Gln Arg Gly Glu Lys Arg Gly Phe 
1               5                   10                  15      


Leu Ser Pro Glu Asn Lys Asn Cys Arg Arg Leu Glu Leu Arg Arg Gly 
            20                  25                  30          


Cys Ser Cys Ser Trp Gly Leu Cys Ser Gln Ala Leu Met Ala Ser Leu 
        35                  40                  45              


Ala Gly Ser Leu Leu Pro Gly Ser Asp Arg Ser Gly Val Glu Thr Ser 
    50                  55                  60                  


Glu Tyr Ala Gln Gly Gly Val Ser Asp Leu Gln Glu Glu Gly Lys Asn 
65                  70                  75                  80  


Ala Ile Asn Ser Pro Met Ser Pro Ala Leu Val Asp Val His Pro Glu 
                85                  90                  95      


Asp Thr Gln Leu Glu Glu Asn Glu Glu Arg Thr Met Ile Asp Pro Thr 
            100                 105                 110         


Ser Lys Glu Asp Pro Lys Phe Lys Glu Leu Val Lys Val Leu Leu Asp 
        115                 120                 125             


Trp Ile Asn Asp Val Leu Val Glu Glu Arg Ile Ile Val Lys Gln Leu 
    130                 135                 140                 


Glu Glu Asp Leu Tyr Asp Gly Gln Val Leu Gln Lys Leu Leu Glu Lys 
145                 150                 155                 160 


Leu Ala Gly Cys Lys Leu Asn Val Ala Glu Val Thr Gln Ser Glu Ile 
                165                 170                 175     


Gly Gln Lys Gln Lys Leu Gln Thr Val Leu Glu Ala Val His Asp Leu 
            180                 185                 190         


Leu Arg Pro Arg Gly Trp Ala Leu Arg Trp Ser Val Asp Ser Ile His 
        195                 200                 205             


Gly Lys Asn Leu Val Ala Ile Leu His Leu Leu Val Ser Leu Ala Met 
    210                 215                 220                 


His Phe Arg Ala Pro Ile Arg Leu Pro Glu His Val Thr Val Gln Val 
225                 230                 235                 240 


Val Val Val Arg Lys Arg Glu Gly Leu Leu His Ser Ser His Ile Ser 
                245                 250                 255     


Glu Glu Leu Thr Thr Thr Thr Glu Met Met Met Gly Arg Phe Glu Arg 
            260                 265                 270         


Asp Ala Phe Asp Thr Leu Phe Asp His Ala Pro Asp Lys Leu Ser Val 
        275                 280                 285             


Val Lys Lys Ser Leu Ile Thr Phe Val Asn Lys His Leu Asn Lys Leu 
    290                 295                 300                 


Asn Leu Glu Val Thr Glu Leu Glu Thr Gln Phe Ala Asp Gly Val Tyr 
305                 310                 315                 320 


Leu Val Leu Leu Met Gly Leu Leu Glu Asp Tyr Phe Val Pro Leu His 
                325                 330                 335     


His Phe Tyr Leu Thr Pro Glu Ser Phe Asp Gln Lys Val His Asn Val 
            340                 345                 350         


Ser Phe Ala Phe Glu Leu Met Leu Asp Gly Gly Leu Lys Lys Pro Lys 
        355                 360                 365             


Ala Arg Pro Glu Asp Val Val Asn Leu Asp Leu Lys Ser Thr Leu Arg 
    370                 375                 380                 


Val Leu Tyr Asn Leu Phe Thr Lys Tyr Lys Asn Val Glu 
385                 390                 395         


<210>  10000
<211>  194
<212>  PRT
<213>  Homo Sapiens

<400>  10000

Met Pro Arg Leu Lys Cys Ser Gly Ala Val Ile Ala His Cys Ser Leu 
1               5                   10                  15      


Glu Leu Leu Ala Ser Ser Asp Pro Ser Ala Ser Ala Ser Gln Gly Ala 
            20                  25                  30          


Arg Thr Thr Val Ser Asp Leu Gln Glu Glu Gly Lys Asn Ala Ile Asn 
        35                  40                  45              


Ser Pro Met Ser Pro Ala Leu Val Asp Val His Pro Glu Asp Thr Gln 
    50                  55                  60                  


Leu Glu Glu Asn Glu Glu Arg Thr Met Ile Asp Pro Thr Ser Lys Glu 
65                  70                  75                  80  


Asp Pro Lys Phe Lys Glu Leu Val Lys Val Leu Leu Asp Trp Ile Asn 
                85                  90                  95      


Asp Val Leu Val Glu Glu Arg Ile Ile Val Lys Gln Leu Glu Glu Asp 
            100                 105                 110         


Leu Tyr Asp Gly Gln Val Leu Gln Lys Leu Leu Glu Lys Leu Ala Gly 
        115                 120                 125             


Cys Lys Leu Asn Val Ala Glu Val Thr Gln Ser Glu Ile Gly Gln Lys 
    130                 135                 140                 


Gln Lys Leu Gln Thr Val Leu Glu Ala Val His Asp Leu Leu Arg Pro 
145                 150                 155                 160 


Arg Gly Trp Ala Leu Arg Trp Ser Val Asp Ser Ile His Gly Lys Asn 
                165                 170                 175     


Leu Val Ala Ile Leu His Leu Leu Val Ser Leu Ala Met His Phe Arg 
            180                 185                 190         


Ala Pro 
        


<210>  10001
<211>  327
<212>  PRT
<213>  Homo Sapiens

<400>  10001

Met Ser Asp Leu Gln Glu Glu Gly Lys Asn Ala Ile Asn Ser Pro Met 
1               5                   10                  15      


Ser Pro Ala Leu Val Asp Val His Pro Glu Asp Thr Gln Leu Glu Glu 
            20                  25                  30          


Asn Glu Glu Arg Thr Met Ile Asp Pro Thr Ser Lys Glu Asp Pro Lys 
        35                  40                  45              


Phe Lys Glu Leu Val Lys Val Leu Leu Asp Trp Ile Asn Asp Val Leu 
    50                  55                  60                  


Val Glu Glu Arg Ile Ile Val Lys Gln Leu Glu Glu Asp Leu Tyr Asp 
65                  70                  75                  80  


Gly Gln Val Leu Gln Lys Leu Leu Glu Lys Leu Ala Gly Cys Lys Leu 
                85                  90                  95      


Asn Val Ala Glu Val Thr Gln Ser Glu Ile Gly Gln Lys Gln Lys Leu 
            100                 105                 110         


Gln Thr Val Leu Glu Ala Val His Asp Leu Leu Arg Pro Arg Gly Trp 
        115                 120                 125             


Ala Leu Arg Trp Ser Val Asp Ser Ile His Gly Lys Asn Leu Val Ala 
    130                 135                 140                 


Ile Leu His Leu Leu Val Ser Leu Ala Met His Phe Arg Ala Pro Ile 
145                 150                 155                 160 


Arg Leu Pro Glu His Val Thr Val Gln Val Val Val Val Arg Lys Arg 
                165                 170                 175     


Glu Gly Leu Leu His Ser Ser His Ile Ser Glu Glu Leu Thr Thr Thr 
            180                 185                 190         


Thr Glu Met Met Met Gly Arg Phe Glu Arg Asp Ala Phe Asp Thr Leu 
        195                 200                 205             


Phe Asp His Ala Pro Asp Lys Leu Ser Val Val Lys Lys Ser Leu Ile 
    210                 215                 220                 


Thr Phe Val Asn Lys His Leu Asn Lys Leu Asn Leu Glu Val Thr Glu 
225                 230                 235                 240 


Leu Glu Thr Gln Phe Ala Asp Gly Val Tyr Leu Val Leu Leu Met Gly 
                245                 250                 255     


Leu Leu Glu Asp Tyr Phe Val Pro Leu His His Phe Tyr Leu Thr Pro 
            260                 265                 270         


Glu Ser Phe Asp Gln Lys Val His Asn Val Ser Phe Ala Phe Glu Leu 
        275                 280                 285             


Met Leu Asp Gly Gly Leu Lys Lys Pro Lys Ala Arg Pro Glu Asp Val 
    290                 295                 300                 


Val Asn Leu Asp Leu Lys Ser Thr Leu Arg Val Leu Tyr Asn Leu Phe 
305                 310                 315                 320 


Thr Lys Tyr Lys Asn Val Glu 
                325         


<210>  10002
<211>  289
<212>  PRT
<213>  Homo Sapiens

<400>  10002

Met Ser Pro Ala Leu Val Asp Val His Pro Glu Asp Thr Gln Leu Glu 
1               5                   10                  15      


Glu Asn Glu Glu Arg Thr Met Ile Asp Pro Thr Ser Lys Glu Asp Pro 
            20                  25                  30          


Lys Phe Lys Glu Leu Val Lys Val Leu Leu Asp Trp Ile Asn Asp Val 
        35                  40                  45              


Leu Val Glu Glu Arg Ile Ile Val Lys Gln Leu Glu Glu Asp Leu Tyr 
    50                  55                  60                  


Asp Gly Gln Val Leu Gln Lys Leu Leu Glu Lys Leu Ala Gly Cys Lys 
65                  70                  75                  80  


Leu Asn Val Ala Glu Val Thr Gln Ser Glu Ile Gly Gln Lys Gln Lys 
                85                  90                  95      


Leu Gln Thr Val Leu Glu Ala Val His Asp Leu Leu Arg Pro Arg Gly 
            100                 105                 110         


Trp Ala Leu Arg Trp Ser Val Asp Ser Ile His Gly Lys Asn Leu Val 
        115                 120                 125             


Ala Ile Leu His Leu Leu Val Ser Leu Ala Met His Phe Arg Ala Pro 
    130                 135                 140                 


Ile Arg Leu Pro Glu His Val Thr Val Gln Val Val Val Val Arg Lys 
145                 150                 155                 160 


Arg Glu Gly Leu Leu His Ser Ser His Ile Ser Glu Glu Leu Thr Thr 
                165                 170                 175     


Thr Thr Glu Met Met Met Gly Arg Phe Glu Arg Asp Ala Phe Asp Thr 
            180                 185                 190         


Leu Phe Asp His Ala Pro Asp Lys Leu Ser Val Val Lys Lys Phe Ala 
        195                 200                 205             


Asp Gly Val Tyr Leu Val Leu Leu Met Gly Leu Leu Glu Asp Tyr Phe 
    210                 215                 220                 


Val Pro Leu His His Phe Tyr Leu Thr Pro Glu Ser Phe Asp Gln Lys 
225                 230                 235                 240 


Val His Asn Val Ser Phe Ala Phe Glu Leu Met Leu Asp Gly Gly Leu 
                245                 250                 255     


Lys Lys Pro Lys Ala Arg Pro Glu Asp Val Val Asn Leu Asp Leu Lys 
            260                 265                 270         


Ser Thr Leu Arg Val Leu Tyr Asn Leu Phe Thr Lys Tyr Lys Asn Val 
        275                 280                 285             


Glu 
    


<210>  10003
<211>  364
<212>  PRT
<213>  Homo Sapiens

<400>  10003

Met Ser Ser Ala Pro Arg Ser Pro Thr Pro Arg Pro Arg Arg Met Lys 
1               5                   10                  15      


Lys Asp Glu Ser Phe Leu Gly Lys Leu Gly Gly Thr Leu Ala Arg Lys 
            20                  25                  30          


Arg Arg Ala Arg Glu Val Ser Asp Leu Gln Glu Glu Gly Lys Asn Ala 
        35                  40                  45              


Ile Asn Ser Pro Met Ser Pro Ala Leu Val Asp Val His Pro Glu Asp 
    50                  55                  60                  


Thr Gln Leu Glu Glu Asn Glu Glu Arg Thr Met Ile Asp Pro Thr Ser 
65                  70                  75                  80  


Lys Glu Asp Pro Lys Phe Lys Glu Leu Val Lys Val Leu Leu Asp Trp 
                85                  90                  95      


Ile Asn Asp Val Leu Val Glu Glu Arg Ile Ile Val Lys Gln Leu Glu 
            100                 105                 110         


Glu Asp Leu Tyr Asp Gly Gln Val Leu Gln Lys Leu Leu Glu Lys Leu 
        115                 120                 125             


Ala Gly Cys Lys Leu Asn Val Ala Glu Val Thr Gln Ser Glu Ile Gly 
    130                 135                 140                 


Gln Lys Gln Lys Leu Gln Thr Val Leu Glu Ala Val His Asp Leu Leu 
145                 150                 155                 160 


Arg Pro Arg Gly Trp Ala Leu Arg Trp Ser Val Asp Ser Ile His Gly 
                165                 170                 175     


Lys Asn Leu Val Ala Ile Leu His Leu Leu Val Ser Leu Ala Met His 
            180                 185                 190         


Phe Arg Ala Pro Ile Arg Leu Pro Glu His Val Thr Val Gln Val Val 
        195                 200                 205             


Val Val Arg Lys Arg Glu Gly Leu Leu His Ser Ser His Ile Ser Glu 
    210                 215                 220                 


Glu Leu Thr Thr Thr Thr Glu Met Met Met Gly Arg Phe Glu Arg Asp 
225                 230                 235                 240 


Ala Phe Asp Thr Leu Phe Asp His Ala Pro Asp Lys Leu Ser Val Val 
                245                 250                 255     


Lys Lys Ser Leu Ile Thr Phe Val Asn Lys His Leu Asn Lys Leu Asn 
            260                 265                 270         


Leu Glu Val Thr Glu Leu Glu Thr Gln Phe Ala Asp Gly Val Tyr Leu 
        275                 280                 285             


Val Leu Leu Met Gly Leu Leu Glu Asp Tyr Phe Val Pro Leu His His 
    290                 295                 300                 


Phe Tyr Leu Thr Pro Glu Ser Phe Asp Gln Lys Val His Asn Val Ser 
305                 310                 315                 320 


Phe Ala Phe Glu Leu Met Leu Asp Gly Gly Leu Lys Lys Pro Lys Ala 
                325                 330                 335     


Arg Pro Glu Asp Val Val Asn Leu Asp Leu Lys Ser Thr Leu Arg Val 
            340                 345                 350         


Leu Tyr Asn Leu Phe Thr Lys Tyr Lys Asn Val Glu 
        355                 360                 


<210>  10004
<211>  114
<212>  PRT
<213>  Homo Sapiens

<400>  10004

Met Asp Lys Ser Leu Leu Leu Glu Leu Pro Ile Leu Leu Cys Cys Phe 
1               5                   10                  15      


Arg Ala Leu Ser Gly Ser Leu Ser Met Arg Asn Asp Ala Val Ile Glu 
            20                  25                  30          


Ile Val Gln Cys Arg Met Cys His Leu Gln Phe Pro Gly Glu Lys Cys 
        35                  40                  45              


Ser Arg Gly Arg Gly Ile Cys Thr Ala Thr Thr Glu Glu Ala Cys Met 
    50                  55                  60                  


Val Gly Arg Met Phe Lys Arg Asp Gly Asn Pro Trp Leu Thr Phe Met 
65                  70                  75                  80  


Gly Cys Leu Lys Asn Cys Ala Asp Val Lys Gly Ile Arg Trp Ser Val 
                85                  90                  95      


Tyr Leu Val Asn Phe Arg Cys Cys Arg Ser His Asp Leu Cys Asn Glu 
            100                 105                 110         


Asp Leu 
        


<210>  10005
<211>  126
<212>  PRT
<213>  Homo Sapiens

<400>  10005

Met Asp Lys Ser Leu Leu Leu Glu Leu Pro Ile Leu Leu Cys Cys Phe 
1               5                   10                  15      


Arg Ala Leu Ser Gly Ser Leu Ser Met Arg Asn Asp Ala Val Asn Glu 
            20                  25                  30          


Ile Val Ala Val Lys Asn Asn Phe Pro Val Ile Glu Ile Val Gln Cys 
        35                  40                  45              


Arg Met Cys His Leu Gln Phe Pro Gly Glu Lys Cys Ser Arg Gly Arg 
    50                  55                  60                  


Gly Ile Cys Thr Ala Thr Thr Glu Glu Ala Cys Met Val Gly Arg Met 
65                  70                  75                  80  


Phe Lys Arg Asp Gly Asn Pro Trp Leu Thr Phe Met Gly Cys Leu Lys 
                85                  90                  95      


Asn Cys Ala Asp Val Lys Gly Ile Arg Trp Ser Val Tyr Leu Val Asn 
            100                 105                 110         


Phe Arg Cys Cys Arg Ser His Asp Leu Cys Asn Glu Asp Leu 
        115                 120                 125     


<210>  10006
<211>  113
<212>  PRT
<213>  Homo Sapiens

<400>  10006

Met Leu Val Leu Phe Leu Leu Gly Thr Val Phe Leu Leu Cys Pro Tyr 
1               5                   10                  15      


Trp Gly Glu Leu His Asp Pro Ile Lys Ala Thr Glu Ile Met Cys Tyr 
            20                  25                  30          


Glu Cys Lys Lys Tyr His Leu Gly Leu Cys Tyr Gly Val Met Thr Ser 
        35                  40                  45              


Cys Ser Leu Lys His Lys Gln Ser Cys Ala Val Glu Asn Phe Tyr Ile 
    50                  55                  60                  


Leu Thr Arg Lys Gly Gln Ser Met Tyr His Tyr Ser Lys Leu Ser Cys 
65                  70                  75                  80  


Met Thr Ser Cys Glu Asp Ile Asn Phe Leu Gly Phe Thr Lys Arg Val 
                85                  90                  95      


Glu Leu Ile Cys Cys Asp His Ser Asn Tyr Cys Asn Leu Pro Glu Gly 
            100                 105                 110         


Val 
    


<210>  10007
<211>  70
<212>  PRT
<213>  Homo Sapiens

<400>  10007

Met Leu Val Leu Phe Leu Leu Gly Thr Val Phe Leu Leu Cys Pro Tyr 
1               5                   10                  15      


Trp Gly Glu Leu His Asp Pro Ile Lys Gly Gln Ser Met Tyr His Tyr 
            20                  25                  30          


Ser Lys Leu Ser Cys Met Thr Ser Cys Glu Asp Ile Asn Phe Leu Gly 
        35                  40                  45              


Phe Thr Lys Arg Val Glu Leu Ile Cys Cys Asp His Ser Asn Tyr Cys 
    50                  55                  60                  


Asn Leu Pro Glu Gly Val 
65                  70  


<210>  10008
<211>  98
<212>  PRT
<213>  Homo Sapiens

<400>  10008

Met Asn Lys His Phe Leu Phe Leu Phe Leu Leu Tyr Cys Leu Ile Val 
1               5                   10                  15      


Ala Val Thr Ser Leu Gln Cys Ile Thr Cys His Leu Arg Thr Arg Thr 
            20                  25                  30          


Asp Arg Cys Arg Arg Gly Phe Gly Val Cys Thr Ala Gln Lys Gly Glu 
        35                  40                  45              


Ala Cys Met Leu Leu Arg Ile Tyr Gln Arg Asn Thr Leu Gln Ile Ser 
    50                  55                  60                  


Tyr Met Val Cys Gln Lys Phe Cys Arg Asp Met Thr Phe Asp Leu Arg 
65                  70                  75                  80  


Asn Arg Thr Tyr Val His Thr Cys Cys Asn Tyr Asn Tyr Cys Asn Phe 
                85                  90                  95      


Lys Leu 
        


<210>  10009
<211>  59
<212>  PRT
<213>  Homo Sapiens

<400>  10009

Met Arg Lys Met Asn Thr Leu Leu Leu Val Ser Leu Ser Phe Leu Tyr 
1               5                   10                  15      


Leu Lys Glu Gly Asp Lys His Met Tyr Ser Thr His Met Cys Lys Tyr 
            20                  25                  30          


Lys Cys Arg Glu Glu Glu Ser Ser Lys Arg Gly Leu Leu Arg Val Thr 
        35                  40                  45              


Leu Cys Cys Asp Arg Asn Phe Cys Asn Val Phe 
    50                  55                  


<210>  10010
<211>  98
<212>  PRT
<213>  Homo Sapiens

<400>  10010

Met Arg Lys Met Asn Thr Leu Leu Leu Val Ser Leu Ser Phe Leu Tyr 
1               5                   10                  15      


Leu Lys Glu Val Met Gly Leu Lys Cys Asn Thr Cys Ile Tyr Thr Glu 
            20                  25                  30          


Gly Trp Lys Cys Met Ala Gly Arg Gly Thr Cys Ile Ala Lys Glu Asn 
        35                  40                  45              


Glu Leu Cys Ser Thr Thr Ala Tyr Phe Arg Gly Asp Lys His Met Tyr 
    50                  55                  60                  


Ser Thr His Met Cys Lys Tyr Lys Cys Arg Glu Glu Glu Ser Ser Lys 
65                  70                  75                  80  


Arg Gly Leu Leu Arg Val Thr Leu Cys Cys Asp Arg Asn Phe Cys Asn 
                85                  90                  95      


Val Phe 
        


<210>  10011
<211>  125
<212>  PRT
<213>  Homo Sapiens

<400>  10011

Met Leu Gly Met Ser Leu Ala Ser Leu His Phe Leu Trp Gln Thr Leu 
1               5                   10                  15      


Asp Tyr Leu Ser Pro Ile Pro Phe Trp Pro Thr Phe Pro Ser Thr Ser 
            20                  25                  30          


Ser Pro Ala Gln His Phe Gly Pro Arg Leu Pro Ser Pro Asp Pro Thr 
        35                  40                  45              


Leu Phe Cys Ser Leu Leu Thr Ser Trp Pro Pro Arg Phe Ser His Leu 
    50                  55                  60                  


Thr Gln Leu His Pro Arg His Gln Arg Ile Leu Gln Gln Gln Gln His 
65                  70                  75                  80  


Ser Gln Thr Pro Arg Glu Pro His Phe Leu Leu Thr Thr Leu Leu Arg 
                85                  90                  95      


Lys Cys Gln Trp Trp Val Ser Leu Lys Gly Cys Ser Ser Trp Leu Lys 
            100                 105                 110         


Val Pro Gln Pro Arg Ser Leu Gly Leu Ser Ser Gln Thr 
        115                 120                 125 


<210>  10012
<211>  543
<212>  PRT
<213>  Homo Sapiens

<400>  10012

Met Asn Cys Leu Glu Gly Pro Gly Lys Thr Cys Gly Pro Leu Ala Ser 
1               5                   10                  15      


Glu Glu Glu Leu Val Ser Ala Cys Gln Leu Glu Lys Glu Glu Glu Asn 
            20                  25                  30          


Glu Gly Glu Glu Glu Glu Glu Glu Glu Asp Glu Glu Asp Leu Asp Pro 
        35                  40                  45              


Asp Leu Asp Pro Asp Leu Glu Glu Glu Glu Asn Asp Leu Gly Asp Pro 
    50                  55                  60                  


Ala Val Leu Gly Ala Val His Asn Thr Gln Arg Ala Leu Leu Ser Ser 
65                  70                  75                  80  


Pro Gly Val Lys Ala Pro Gly Met Leu Gly Met Ser Leu Ala Ser Leu 
                85                  90                  95      


His Phe Leu Trp Gln Thr Leu Asp Tyr Leu Ser Pro Ile Pro Phe Trp 
            100                 105                 110         


Pro Thr Phe Pro Ser Thr Ser Ser Pro Ala Gln His Phe Gly Pro Arg 
        115                 120                 125             


Leu Pro Ser Pro Asp Pro Thr Leu Phe Cys Ser Leu Leu Thr Ser Trp 
    130                 135                 140                 


Pro Pro Arg Phe Ser His Leu Thr Gln Leu His Pro Arg His Gln Arg 
145                 150                 155                 160 


Ile Leu Gln Gln Gln Gln His Ser Gln Thr Pro Ser Pro Pro Ala Lys 
                165                 170                 175     


Lys Pro Trp Ser Gln Gln Pro Asp Pro Tyr Ala Asn Leu Met Thr Arg 
            180                 185                 190         


Lys Glu Lys Asp Trp Val Ile Lys Val Gln Met Val Gln Leu Gln Ser 
        195                 200                 205             


Ala Lys Pro Arg Leu Asp Asp Tyr Tyr Tyr Gln Glu Tyr Tyr Gln Lys 
    210                 215                 220                 


Leu Glu Lys Lys Gln Ala Asp Glu Glu Leu Leu Gly Arg Arg Asn Arg 
225                 230                 235                 240 


Val Glu Ser Leu Lys Leu Val Thr Pro Tyr Ile Pro Lys Ala Glu Ala 
                245                 250                 255     


Tyr Glu Ser Val Val Arg Ile Glu Gly Ser Leu Gly Gln Val Ala Val 
            260                 265                 270         


Ser Thr Cys Phe Ser Pro Arg Arg Ala Ile Asp Ala Val Pro His Gly 
        275                 280                 285             


Thr Gln Glu Gln Asp Ile Glu Ala Ala Ser Ser Gln Arg Leu Arg Val 
    290                 295                 300                 


Leu Tyr Arg Ile Glu Lys Met Phe Leu Gln Leu Leu Glu Ile Glu Glu 
305                 310                 315                 320 


Gly Trp Lys Tyr Arg Pro Pro Pro Pro Cys Phe Ser Glu Gln Gln Ser 
                325                 330                 335     


Asn Gln Val Glu Lys Leu Phe Gln Thr Leu Lys Thr Gln Glu Gln Asn 
            340                 345                 350         


Asn Leu Glu Glu Ala Ala Asp Gly Phe Leu Gln Val Leu Ser Val Arg 
        355                 360                 365             


Lys Gly Lys Ala Leu Val Ala Arg Leu Leu Pro Phe Leu Pro Gln Asp 
    370                 375                 380                 


Gln Ala Val Thr Ile Leu Leu Ala Ile Thr His His Leu Pro Leu Leu 
385                 390                 395                 400 


Val Arg Arg Asp Val Ala Asp Gln Ala Leu Gln Met Leu Phe Lys Pro 
                405                 410                 415     


Leu Gly Lys Cys Ile Ser His Leu Thr Leu His Glu Leu Leu Gln Gly 
            420                 425                 430         


Leu Gln Gly Leu Thr Leu Leu Pro Pro Gly Ser Ser Glu Arg Pro Val 
        435                 440                 445             


Thr Val Val Leu Gln Asn Gln Phe Gly Ile Ser Leu Leu Tyr Ala Leu 
    450                 455                 460                 


Leu Ser His Gly Glu Gln Leu Val Ser Leu His Ser Ser Leu Glu Glu 
465                 470                 475                 480 


Pro Asn Ser Asp His Thr Ala Trp Thr Asp Met Val Val Leu Ile Ala 
                485                 490                 495     


Trp Glu Ile Ala Gln Met Pro Thr Ala Ser Leu Ala Glu Pro Leu Ala 
            500                 505                 510         


Phe Pro Ser Asn Leu Leu Pro Leu Phe Cys His His Val Asp Lys Gln 
        515                 520                 525             


Leu Val Gln Gln Leu Glu Ala Arg Met Glu Phe Ala Trp Ile Tyr 
    530                 535                 540             


<210>  10013
<211>  543
<212>  PRT
<213>  Homo Sapiens

<400>  10013

Met Asn Cys Leu Glu Gly Pro Gly Lys Thr Cys Gly Pro Leu Ala Ser 
1               5                   10                  15      


Glu Glu Glu Leu Val Ser Ala Cys Gln Leu Glu Lys Glu Glu Glu Asn 
            20                  25                  30          


Glu Gly Glu Glu Glu Glu Glu Glu Glu Asp Glu Glu Asp Leu Asp Pro 
        35                  40                  45              


Asp Leu Asp Pro Asp Leu Glu Glu Glu Glu Asn Asp Leu Gly Asp Pro 
    50                  55                  60                  


Ala Val Leu Gly Ala Val His Asn Thr Gln Arg Ala Leu Leu Ser Ser 
65                  70                  75                  80  


Pro Gly Val Lys Ala Pro Gly Met Leu Gly Met Ser Leu Ala Ser Leu 
                85                  90                  95      


His Phe Leu Trp Gln Thr Leu Asp Tyr Leu Ser Pro Ile Pro Phe Trp 
            100                 105                 110         


Pro Thr Phe Pro Ser Thr Ser Ser Pro Ala Gln His Phe Gly Pro Arg 
        115                 120                 125             


Leu Pro Ser Pro Asp Pro Thr Leu Phe Cys Ser Leu Leu Thr Ser Trp 
    130                 135                 140                 


Pro Pro Arg Phe Ser His Leu Thr Gln Leu His Pro Arg His Gln Arg 
145                 150                 155                 160 


Ile Leu Gln Gln Gln Gln His Ser Gln Thr Pro Ser Pro Pro Ala Lys 
                165                 170                 175     


Lys Pro Trp Ser Gln Gln Pro Asp Pro Tyr Ala Asn Leu Met Thr Arg 
            180                 185                 190         


Lys Glu Lys Asp Trp Val Ile Lys Val Gln Met Val Gln Leu Gln Ser 
        195                 200                 205             


Ala Lys Pro Arg Leu Asp Asp Tyr Tyr Tyr Gln Glu Tyr Tyr Gln Lys 
    210                 215                 220                 


Leu Glu Lys Lys Gln Ala Asp Glu Glu Leu Leu Gly Arg Arg Asn Arg 
225                 230                 235                 240 


Val Glu Ser Leu Lys Leu Val Thr Pro Tyr Ile Pro Lys Ala Glu Ala 
                245                 250                 255     


Tyr Glu Ser Val Val Arg Ile Glu Gly Ser Leu Gly Gln Val Ala Val 
            260                 265                 270         


Ser Thr Cys Phe Ser Pro Arg Arg Ala Ile Asp Ala Val Pro His Gly 
        275                 280                 285             


Thr Gln Glu Gln Asp Ile Glu Ala Ala Ser Ser Gln Arg Leu Arg Val 
    290                 295                 300                 


Leu Tyr Arg Ile Glu Lys Met Phe Leu Gln Leu Leu Glu Ile Glu Glu 
305                 310                 315                 320 


Gly Trp Lys Tyr Arg Pro Pro Pro Pro Cys Phe Ser Glu Gln Gln Ser 
                325                 330                 335     


Asn Gln Val Glu Lys Leu Phe Gln Thr Leu Lys Thr Gln Glu Gln Asn 
            340                 345                 350         


Asn Leu Glu Glu Ala Ala Asp Gly Phe Leu Gln Val Leu Ser Val Arg 
        355                 360                 365             


Lys Gly Lys Ala Leu Val Ala Arg Leu Leu Pro Phe Leu Pro Gln Asp 
    370                 375                 380                 


Gln Ala Val Thr Ile Leu Leu Ala Ile Thr His His Leu Pro Leu Leu 
385                 390                 395                 400 


Val Arg Arg Asp Val Ala Asp Gln Ala Leu Gln Met Leu Phe Lys Pro 
                405                 410                 415     


Leu Gly Lys Cys Ile Ser His Leu Thr Leu His Glu Leu Leu Gln Gly 
            420                 425                 430         


Leu Gln Gly Leu Thr Leu Leu Pro Pro Gly Ser Ser Glu Arg Pro Val 
        435                 440                 445             


Thr Val Val Leu Gln Asn Gln Phe Gly Ile Ser Leu Leu Tyr Ala Leu 
    450                 455                 460                 


Leu Ser His Gly Glu Gln Leu Val Ser Leu His Ser Ser Leu Glu Glu 
465                 470                 475                 480 


Pro Asn Ser Asp His Thr Ala Trp Thr Asp Met Val Val Leu Ile Ala 
                485                 490                 495     


Trp Glu Ile Ala Gln Met Pro Thr Ala Ser Leu Ala Glu Pro Leu Ala 
            500                 505                 510         


Phe Pro Ser Asn Leu Leu Pro Leu Phe Cys His His Val Asp Lys Gln 
        515                 520                 525             


Leu Val Gln Gln Leu Glu Ala Arg Met Glu Phe Ala Trp Ile Tyr 
    530                 535                 540             


<210>  10014
<211>  354
<212>  PRT
<213>  Homo Sapiens

<400>  10014

Met Thr Arg Lys Glu Lys Asp Trp Val Ile Lys Val Gln Met Val Gln 
1               5                   10                  15      


Leu Gln Ser Ala Lys Pro Arg Leu Asp Asp Tyr Tyr Tyr Gln Glu Tyr 
            20                  25                  30          


Tyr Gln Lys Leu Glu Lys Lys Gln Ala Asp Glu Glu Leu Leu Gly Arg 
        35                  40                  45              


Arg Asn Arg Val Glu Ser Leu Lys Leu Val Thr Pro Tyr Ile Pro Lys 
    50                  55                  60                  


Ala Glu Ala Tyr Glu Ser Val Val Arg Ile Glu Gly Ser Leu Gly Gln 
65                  70                  75                  80  


Val Ala Val Ser Thr Cys Phe Ser Pro Arg Arg Ala Ile Asp Ala Val 
                85                  90                  95      


Pro His Gly Thr Gln Glu Gln Asp Ile Glu Ala Ala Ser Ser Gln Arg 
            100                 105                 110         


Leu Arg Val Leu Tyr Arg Ile Glu Lys Met Phe Leu Gln Leu Leu Glu 
        115                 120                 125             


Ile Glu Glu Gly Trp Lys Tyr Arg Pro Pro Pro Pro Cys Phe Ser Glu 
    130                 135                 140                 


Gln Gln Ser Asn Gln Val Glu Lys Leu Phe Gln Thr Leu Lys Thr Gln 
145                 150                 155                 160 


Glu Gln Asn Asn Leu Glu Glu Ala Ala Asp Gly Phe Leu Gln Val Leu 
                165                 170                 175     


Ser Val Arg Lys Gly Lys Ala Leu Val Ala Arg Leu Leu Pro Phe Leu 
            180                 185                 190         


Pro Gln Asp Gln Ala Val Thr Ile Leu Leu Ala Ile Thr His His Leu 
        195                 200                 205             


Pro Leu Leu Val Arg Arg Asp Val Ala Asp Gln Ala Leu Gln Met Leu 
    210                 215                 220                 


Phe Lys Pro Leu Gly Lys Cys Ile Ser His Leu Thr Leu His Glu Leu 
225                 230                 235                 240 


Leu Gln Gly Leu Gln Gly Leu Thr Leu Leu Pro Pro Gly Ser Ser Glu 
                245                 250                 255     


Arg Pro Val Thr Val Val Leu Gln Asn Gln Phe Gly Ile Ser Leu Leu 
            260                 265                 270         


Tyr Ala Leu Leu Ser His Gly Glu Gln Leu Val Ser Leu His Ser Ser 
        275                 280                 285             


Leu Glu Glu Pro Asn Ser Asp His Thr Ala Trp Thr Asp Met Val Val 
    290                 295                 300                 


Leu Ile Ala Trp Glu Ile Ala Gln Met Pro Thr Ala Ser Leu Ala Glu 
305                 310                 315                 320 


Pro Leu Ala Phe Pro Ser Asn Leu Leu Pro Leu Phe Cys His His Val 
                325                 330                 335     


Asp Lys Gln Leu Val Gln Gln Leu Glu Ala Arg Met Glu Phe Ala Trp 
            340                 345                 350         


Ile Tyr 
        


<210>  10015
<211>  158
<212>  PRT
<213>  Homo Sapiens

<400>  10015

Gln Ala Leu Gln Met Leu Phe Lys Pro Leu Gly Lys Cys Ile Ser His 
1               5                   10                  15      


Leu Thr Leu His Glu Leu Leu Gln Gly Leu Gln Gly Leu Thr Leu Leu 
            20                  25                  30          


Pro Pro Gly Ser Ser Glu Arg Pro Val Thr Val Val Leu Gln Asn Gln 
        35                  40                  45              


Asp Arg His Gly Gly Ser Asp Cys Leu Gly Asp Ser Pro Asn Ala Tyr 
    50                  55                  60                  


Ser Leu Ser Gly Arg Thr Pro Ser Phe Pro Gln Gln Pro Thr Ser Pro 
65                  70                  75                  80  


Val Leu Ser Pro Arg Gly Gln Thr Ile Gly Ser Ala Ala Gly Gly Gln 
                85                  90                  95      


Asp Gly Val Cys Leu Asp Leu Leu Ile Cys Leu Phe Trp Asn Thr Cys 
            100                 105                 110         


Met Trp Glu Val Glu Ser Ser Asp Thr Ser Tyr Ile Asp Tyr Val Tyr 
        115                 120                 125             


Arg Asp Pro Glu Ser Leu Lys Thr Phe Leu Met Pro Leu Tyr Ile Gly 
    130                 135                 140                 


Glu Pro Phe Pro Ile Phe Ile Ser Phe Leu Gln Lys Ser Lys 
145                 150                 155             


<210>  10016
<211>  188
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  10016

Xaa Glu Asn Glu Gly Glu Glu Glu Glu Glu Glu Glu Asp Glu Glu Asp 
1               5                   10                  15      


Leu Asp Pro Asp Leu Asp Pro Asp Leu Glu Glu Glu Glu Asn Asp Leu 
            20                  25                  30          


Gly Asp Pro Ala Val Leu Gly Ala Val His Asn Thr Gln Arg Ala Leu 
        35                  40                  45              


Leu Ser Ser Pro Gly Val Lys Ala Pro Gly Met Leu Gly Met Ser Leu 
    50                  55                  60                  


Ala Ser Leu His Phe Leu Trp Gln Thr Leu Asp Tyr Leu Ser Pro Ile 
65                  70                  75                  80  


Pro Phe Trp Pro Thr Phe Pro Ser Thr Ser Ser Pro Ala Gln His Phe 
                85                  90                  95      


Gly Pro Arg Leu Pro Ser Pro Asp Pro Thr Leu Phe Cys Ser Leu Leu 
            100                 105                 110         


Thr Ser Trp Pro Pro Arg Phe Ser His Leu Thr Gln Leu His Pro Arg 
        115                 120                 125             


His Gln Arg Ile Leu Gln Gln Gln Gln His Ser Gln Thr Pro Arg Glu 
    130                 135                 140                 


Pro His Phe Leu Leu Thr Thr Leu Leu Arg Lys Cys Gln Trp Trp Val 
145                 150                 155                 160 


Ser Leu Lys Gly Cys Ser Ser Trp Leu Lys Val Pro Gln Pro Arg Ser 
                165                 170                 175     


Leu Gly Leu Ser Ser Gln Thr Pro Met Leu Thr Ser 
            180                 185             


<210>  10017
<211>  304
<212>  PRT
<213>  Homo Sapiens

<400>  10017

Met Ala Gly Pro Cys Cys Val Trp Gly Val Val Phe Phe Ser Cys Leu 
1               5                   10                  15      


Ser Pro Ala Gly His Gly Gly Val Asn Gln Leu Gly Gly Val Phe Val 
            20                  25                  30          


Asn Gly Arg Pro Leu Pro Asp Val Val Arg Gln Arg Ile Val Glu Leu 
        35                  40                  45              


Ala His Gln Gly Val Arg Pro Cys Asp Ile Ser Arg Gln Leu Arg Val 
    50                  55                  60                  


Ser His Gly Cys Val Ser Lys Ile Leu Gly Arg Tyr Tyr Glu Thr Gly 
65                  70                  75                  80  


Ser Ile Lys Pro Gly Val Ile Gly Gly Ser Lys Pro Lys Val Ala Thr 
                85                  90                  95      


Pro Lys Val Val Asp Lys Ile Ala Glu Tyr Lys Arg Gln Asn Pro Thr 
            100                 105                 110         


Met Phe Ala Trp Glu Ile Arg Asp Arg Leu Leu Ala Glu Gly Ile Cys 
        115                 120                 125             


Asp Asn Asp Thr Val Pro Ser Val Ser Ser Ile Asn Arg Ile Ile Arg 
    130                 135                 140                 


Thr Lys Val Gln Gln Pro Phe His Pro Thr Pro Asp Gly Ala Gly Thr 
145                 150                 155                 160 


Gly Val Thr Ala Pro Gly His Thr Ile Val Pro Ser Thr Ala Ser Pro 
                165                 170                 175     


Pro Val Ser Ser Ala Ser Asn Asp Pro Val Gly Ser Tyr Ser Ile Asn 
            180                 185                 190         


Gly Ile Leu Gly Ile Pro Arg Ser Asn Asp Val Ser Glu Gly Ser Val 
        195                 200                 205             


Pro Asn Gly Asp Ser Gln Ser Gly Val Asp Ser Leu Arg Lys His Leu 
    210                 215                 220                 


Arg Ala Asp Thr Phe Thr Gln Gln Gln Leu Glu Ala Leu Asp Arg Val 
225                 230                 235                 240 


Phe Glu Arg Pro Ser Tyr Pro Asp Val Phe Gln Ala Ser Glu His Ile 
                245                 250                 255     


Lys Ser Glu Gln Gly Asn Glu Tyr Ser Leu Pro Ala Leu Thr Pro Gly 
            260                 265                 270         


Leu Asp Glu Val Lys Ser Ser Leu Ser Ala Ser Thr Asn Pro Glu Leu 
        275                 280                 285             


Gly Ser Asn Val Ser Gly Thr Gln Thr Tyr Pro Val Val Thr Gly Arg 
    290                 295                 300                 


<210>  10018
<211>  396
<212>  PRT
<213>  Homo Sapiens

<400>  10018

Met Asp Met His Cys Lys Ala Asp Pro Phe Ser Ala Met His Pro Gly 
1               5                   10                  15      


His Gly Gly Val Asn Gln Leu Gly Gly Val Phe Val Asn Gly Arg Pro 
            20                  25                  30          


Leu Pro Asp Val Val Arg Gln Arg Ile Val Glu Leu Ala His Gln Gly 
        35                  40                  45              


Val Arg Pro Cys Asp Ile Ser Arg Gln Leu Arg Val Ser His Gly Cys 
    50                  55                  60                  


Val Ser Lys Ile Leu Gly Arg Tyr Tyr Glu Thr Gly Ser Ile Lys Pro 
65                  70                  75                  80  


Gly Val Ile Gly Gly Ser Lys Pro Lys Val Ala Thr Pro Lys Val Val 
                85                  90                  95      


Asp Lys Ile Ala Glu Tyr Lys Arg Gln Asn Pro Thr Met Phe Ala Trp 
            100                 105                 110         


Glu Ile Arg Asp Arg Leu Leu Ala Glu Gly Ile Cys Asp Asn Asp Thr 
        115                 120                 125             


Val Pro Ser Val Ser Ser Ile Asn Arg Ile Ile Arg Thr Lys Val Gln 
    130                 135                 140                 


Gln Pro Phe His Pro Thr Pro Asp Gly Ala Gly Thr Gly Val Thr Ala 
145                 150                 155                 160 


Pro Gly His Thr Ile Val Pro Ser Thr Ala Ser Pro Pro Val Ser Ser 
                165                 170                 175     


Ala Ser Asn Asp Pro Val Gly Ser Tyr Ser Ile Asn Gly Ile Leu Gly 
            180                 185                 190         


Ile Pro Arg Ser Asn Gly Glu Lys Arg Lys Arg Asp Glu Asp Val Ser 
        195                 200                 205             


Glu Gly Ser Val Pro Asn Gly Asp Ser Gln Ser Gly Val Asp Ser Leu 
    210                 215                 220                 


Arg Lys His Leu Arg Ala Asp Thr Phe Thr Gln Gln Gln Leu Glu Ala 
225                 230                 235                 240 


Leu Asp Arg Val Phe Glu Arg Pro Ser Tyr Pro Asp Val Phe Gln Ala 
                245                 250                 255     


Ser Glu His Ile Lys Ser Glu Gln Gly Asn Glu Tyr Ser Leu Pro Ala 
            260                 265                 270         


Leu Thr Pro Gly Leu Asp Glu Val Lys Ser Ser Leu Ser Ala Ser Thr 
        275                 280                 285             


Asn Pro Glu Leu Gly Ser Asn Val Ser Gly Thr Gln Thr Tyr Pro Val 
    290                 295                 300                 


Val Thr Gly Arg Asp Met Ala Ser Thr Thr Leu Pro Gly Tyr Pro Pro 
305                 310                 315                 320 


His Val Pro Pro Thr Gly Gln Gly Ser Tyr Pro Thr Ser Thr Leu Ala 
                325                 330                 335     


Gly Met Val Pro Glu Ala Ala Val Gly Pro Ser Ser Ser Leu Met Ser 
            340                 345                 350         


Lys Pro Gly Arg Lys Leu Ala Glu Val Pro Pro Cys Val Gln Pro Thr 
        355                 360                 365             


Gly Ala Ser Ser Pro Ala Thr Arg Thr Ala Thr Pro Ser Thr Arg Pro 
    370                 375                 380                 


Thr Thr Arg Leu Gly Asp Ser Ala Thr Pro Pro Tyr 
385                 390                 395     


<210>  10019
<211>  394
<212>  PRT
<213>  Homo Sapiens

<400>  10019

Met Asp Met His Cys Lys Ala Asp Pro Phe Ser Ala Met His Pro Gly 
1               5                   10                  15      


His Gly Gly Val Asn Gln Leu Gly Gly Val Phe Val Asn Gly Arg Pro 
            20                  25                  30          


Leu Pro Asp Val Val Arg Gln Arg Ile Val Glu Leu Ala His Gln Gly 
        35                  40                  45              


Val Arg Pro Cys Asp Ile Ser Arg Gln Leu Arg Val Ser His Gly Cys 
    50                  55                  60                  


Val Ser Lys Ile Leu Gly Arg Tyr Tyr Glu Thr Gly Ser Ile Lys Pro 
65                  70                  75                  80  


Gly Val Ile Gly Gly Ser Lys Pro Lys Val Ala Thr Pro Lys Val Val 
                85                  90                  95      


Asp Lys Ile Ala Glu Tyr Lys Arg Gln Asn Pro Thr Met Phe Ala Trp 
            100                 105                 110         


Glu Ile Arg Asp Arg Leu Leu Ala Glu Gly Ile Cys Asp Asn Asp Thr 
        115                 120                 125             


Val Pro Ser Val Ser Ser Ile Asn Arg Ile Ile Arg Thr Lys Val Gln 
    130                 135                 140                 


Gln Pro Phe His Pro Thr Pro Asp Gly Ala Gly Thr Gly Val Thr Ala 
145                 150                 155                 160 


Pro Gly His Thr Ile Val Pro Ser Thr Ala Ser Pro Pro Val Ser Ser 
                165                 170                 175     


Ala Ser Asn Asp Pro Val Gly Ser Tyr Ser Ile Asn Gly Ile Leu Gly 
            180                 185                 190         


Ile Pro Arg Ser Asn Gly Glu Lys Arg Lys Arg Asp Glu Asp Val Ser 
        195                 200                 205             


Glu Gly Ser Val Pro Asn Gly Asp Ser Gln Ser Gly Val Asp Ser Leu 
    210                 215                 220                 


Arg Lys His Leu Arg Ala Asp Thr Phe Thr Gln Gln Gln Leu Glu Ala 
225                 230                 235                 240 


Leu Asp Arg Val Phe Glu Arg Pro Ser Tyr Pro Asp Val Phe Gln Ala 
                245                 250                 255     


Ser Glu His Ile Lys Ser Glu Gln Gly Asn Glu Tyr Ser Leu Pro Ala 
            260                 265                 270         


Leu Thr Pro Gly Leu Asp Glu Val Lys Ser Ser Leu Ser Ala Ser Thr 
        275                 280                 285             


Asn Pro Glu Leu Gly Ser Asn Val Ser Gly Thr Gln Thr Tyr Pro Val 
    290                 295                 300                 


Val Thr Gly Arg Asp Met Ala Ser Thr Thr Leu Pro Gly Tyr Pro Pro 
305                 310                 315                 320 


His Val Pro Pro Thr Gly Gln Gly Ser Tyr Pro Thr Ser Thr Leu Ala 
                325                 330                 335     


Gly Met Val Pro Gly Ser Glu Phe Ser Gly Asn Pro Tyr Ser His Pro 
            340                 345                 350         


Gln Tyr Thr Ala Tyr Asn Glu Ala Trp Arg Phe Ser Asn Pro Ala Leu 
        355                 360                 365             


Leu Ser Ser Pro Tyr Tyr Tyr Ser Ala Ala Pro Arg Gly Ser Ala Pro 
    370                 375                 380                 


Ala Ala Ala Ala Ala Ala Tyr Asp Arg His 
385                 390                 


<210>  10020
<211>  214
<212>  PRT
<213>  Homo Sapiens

<400>  10020

Met Asp Met His Cys Lys Ala Asp Pro Phe Ser Ala Met His Pro Gly 
1               5                   10                  15      


His Gly Gly Val Asn Gln Leu Gly Gly Val Phe Val Asn Gly Arg Pro 
            20                  25                  30          


Leu Pro Asp Val Val Arg Gln Arg Ile Val Glu Leu Ala His Gln Gly 
        35                  40                  45              


Val Arg Pro Cys Asp Ile Ser Arg Gln Leu Arg Val Ser His Gly Cys 
    50                  55                  60                  


Val Ser Lys Ile Leu Gly Arg Tyr Tyr Glu Thr Gly Ser Ile Lys Pro 
65                  70                  75                  80  


Gly Val Ile Gly Gly Ser Lys Pro Lys Val Ala Thr Pro Lys Val Val 
                85                  90                  95      


Asp Lys Ile Ala Glu Tyr Lys Arg Gln Asn Pro Thr Met Phe Ala Trp 
            100                 105                 110         


Glu Ile Arg Asp Arg Leu Leu Ala Glu Gly Ile Cys Asp Asn Asp Thr 
        115                 120                 125             


Val Pro Ser Val Ser Ser Ile Asn Arg Ile Ile Arg Thr Lys Val Gln 
    130                 135                 140                 


Gln Pro Phe His Pro Thr Pro Asp Gly Ala Gly Thr Gly Val Thr Ala 
145                 150                 155                 160 


Pro Gly His Thr Ile Val Pro Ser Thr Ala Ser Pro Pro Val Ser Ser 
                165                 170                 175     


Ala Ser Asn Asp Pro Val Gly Ser Tyr Ser Ile Asn Gly Ile Leu Gly 
            180                 185                 190         


Ile Pro Arg Ser Asn Gly Glu Lys Arg Lys Arg Asp Glu Val Glu Val 
        195                 200                 205             


Tyr Thr Asp Pro Ala His 
    210                 


<210>  10021
<211>  417
<212>  PRT
<213>  Homo Sapiens

<400>  10021

Met Asp Met His Cys Lys Ala Asp Pro Phe Ser Ala Met His Pro Gly 
1               5                   10                  15      


His Gly Gly Val Asn Gln Leu Gly Gly Val Phe Val Asn Gly Arg Pro 
            20                  25                  30          


Leu Pro Asp Val Val Arg Gln Arg Ile Val Glu Leu Ala His Gln Gly 
        35                  40                  45              


Val Arg Pro Cys Asp Ile Ser Arg Gln Leu Arg Val Ser His Gly Cys 
    50                  55                  60                  


Val Ser Lys Ile Leu Gly Arg Tyr Tyr Glu Thr Gly Ser Ile Lys Pro 
65                  70                  75                  80  


Gly Val Ile Gly Gly Ser Lys Pro Lys Val Ala Thr Pro Lys Val Val 
                85                  90                  95      


Asp Lys Ile Ala Glu Tyr Lys Arg Gln Asn Pro Thr Met Phe Ala Trp 
            100                 105                 110         


Glu Ile Arg Asp Arg Leu Leu Ala Glu Gly Ile Cys Asp Asn Asp Thr 
        115                 120                 125             


Val Pro Ser Val Ser Ser Ile Asn Arg Ile Ile Arg Thr Lys Val Gln 
    130                 135                 140                 


Gln Pro Phe His Pro Thr Pro Asp Gly Ala Gly Thr Gly Val Thr Ala 
145                 150                 155                 160 


Pro Gly His Thr Ile Val Pro Ser Thr Ala Ser Pro Pro Val Ser Ser 
                165                 170                 175     


Ala Ser Asn Asp Pro Val Gly Ser Tyr Ser Ile Asn Gly Ile Leu Gly 
            180                 185                 190         


Ile Pro Arg Ser Asn Gly Glu Lys Arg Lys Arg Asp Glu Val Glu Val 
        195                 200                 205             


Tyr Thr Asp Pro Ala His Ile Arg Gly Gly Gly Gly Leu His Leu Val 
    210                 215                 220                 


Trp Thr Leu Arg Asp Val Ser Glu Gly Ser Val Pro Asn Gly Asp Ser 
225                 230                 235                 240 


Gln Ser Gly Val Asp Ser Leu Arg Lys His Leu Arg Ala Asp Thr Phe 
                245                 250                 255     


Thr Gln Gln Gln Leu Glu Ala Leu Asp Arg Val Phe Glu Arg Pro Ser 
            260                 265                 270         


Tyr Pro Asp Val Phe Gln Ala Ser Glu His Ile Lys Ser Glu Gln Gly 
        275                 280                 285             


Asn Glu Tyr Ser Leu Pro Ala Leu Thr Pro Gly Leu Asp Glu Val Lys 
    290                 295                 300                 


Ser Ser Leu Ser Ala Ser Thr Asn Pro Glu Leu Gly Ser Asn Val Ser 
305                 310                 315                 320 


Gly Thr Gln Thr Tyr Pro Val Val Thr Gly Arg Asp Met Ala Ser Thr 
                325                 330                 335     


Thr Leu Pro Gly Tyr Pro Pro His Val Pro Pro Thr Gly Gln Gly Ser 
            340                 345                 350         


Tyr Pro Thr Ser Thr Leu Ala Gly Met Val Pro Gly Ser Glu Phe Ser 
        355                 360                 365             


Gly Asn Pro Tyr Ser His Pro Gln Tyr Thr Ala Tyr Asn Glu Ala Trp 
    370                 375                 380                 


Arg Phe Ser Asn Pro Ala Leu Leu Ser Ser Pro Tyr Tyr Tyr Ser Ala 
385                 390                 395                 400 


Ala Pro Arg Gly Ser Ala Pro Ala Ala Ala Ala Ala Ala Tyr Asp Arg 
                405                 410                 415     


His 
    


<210>  10022
<211>  393
<212>  PRT
<213>  Homo Sapiens

<400>  10022

Met Asp Met His Cys Lys Ala Asp Pro Phe Ser Ala Met His Arg His 
1               5                   10                  15      


Gly Gly Val Asn Gln Leu Gly Gly Val Phe Val Asn Gly Arg Pro Leu 
            20                  25                  30          


Pro Asp Val Val Arg Gln Arg Ile Val Glu Leu Ala His Gln Gly Val 
        35                  40                  45              


Arg Pro Cys Asp Ile Ser Arg Gln Leu Arg Val Ser His Gly Cys Val 
    50                  55                  60                  


Ser Lys Ile Leu Gly Arg Tyr Tyr Glu Thr Gly Ser Ile Lys Pro Gly 
65                  70                  75                  80  


Val Ile Gly Gly Ser Lys Pro Lys Val Ala Thr Pro Lys Val Val Asp 
                85                  90                  95      


Lys Ile Ala Glu Tyr Lys Arg Gln Asn Pro Thr Met Phe Ala Trp Glu 
            100                 105                 110         


Ile Arg Asp Arg Leu Leu Ala Glu Gly Ile Cys Asp Asn Asp Thr Val 
        115                 120                 125             


Pro Ser Val Ser Ser Ile Asn Arg Ile Ile Arg Thr Lys Val Gln Gln 
    130                 135                 140                 


Pro Phe His Pro Thr Pro Asp Gly Ala Gly Thr Gly Val Thr Ala Pro 
145                 150                 155                 160 


Gly His Thr Ile Val Pro Ser Thr Ala Ser Pro Pro Val Ser Ser Ala 
                165                 170                 175     


Ser Asn Asp Pro Val Gly Ser Tyr Ser Ile Asn Gly Ile Leu Gly Ile 
            180                 185                 190         


Pro Arg Ser Asn Gly Glu Lys Arg Lys Arg Asp Glu Asp Val Ser Glu 
        195                 200                 205             


Gly Ser Val Pro Asn Gly Asp Ser Gln Ser Gly Val Asp Ser Leu Arg 
    210                 215                 220                 


Lys His Leu Arg Ala Asp Thr Phe Thr Gln Gln Gln Leu Glu Ala Leu 
225                 230                 235                 240 


Asp Arg Val Phe Glu Arg Pro Ser Tyr Pro Asp Val Phe Gln Ala Ser 
                245                 250                 255     


Glu His Ile Lys Ser Glu Gln Gly Asn Glu Tyr Ser Leu Pro Ala Leu 
            260                 265                 270         


Thr Pro Gly Leu Asp Glu Val Lys Ser Ser Leu Ser Ala Ser Thr Asn 
        275                 280                 285             


Pro Glu Leu Gly Ser Asn Val Ser Gly Thr Gln Thr Tyr Pro Val Val 
    290                 295                 300                 


Thr Gly Arg Asp Met Ala Ser Thr Thr Leu Pro Gly Tyr Pro Pro His 
305                 310                 315                 320 


Val Pro Pro Thr Gly Gln Gly Ser Tyr Pro Thr Ser Thr Leu Ala Gly 
                325                 330                 335     


Met Val Pro Gly Ser Glu Phe Ser Gly Asn Pro Tyr Ser His Pro Gln 
            340                 345                 350         


Tyr Thr Ala Tyr Asn Glu Ala Trp Arg Phe Ser Asn Pro Ala Leu Leu 
        355                 360                 365             


Ser Ser Pro Tyr Tyr Tyr Ser Ala Ala Pro Arg Gly Ser Ala Pro Ala 
    370                 375                 380                 


Ala Ala Ala Ala Ala Tyr Asp Arg His 
385                 390             


<210>  10023
<211>  257
<212>  PRT
<213>  Homo Sapiens

<400>  10023

Met Ala Trp Ser Ser Lys Ser Trp Leu Cys Leu Ile Ala Ser Ser Cys 
1               5                   10                  15      


Pro Arg Asp Thr Leu Leu Pro Ser Ala His His Ala Ser Pro Val Pro 
            20                  25                  30          


Ala Ser His Leu Thr Gln Val Ser Asn Gly Cys Val Ser Lys Ile Leu 
        35                  40                  45              


Gly Arg Tyr Tyr Arg Thr Gly Val Leu Glu Pro Lys Gly Ile Gly Gly 
    50                  55                  60                  


Ser Lys Pro Arg Leu Ala Thr Pro Pro Val Val Ala Arg Ile Ala Gln 
65                  70                  75                  80  


Leu Lys Gly Glu Cys Pro Ala Leu Phe Ala Trp Glu Ile Gln Arg Gln 
                85                  90                  95      


Leu Cys Ala Glu Gly Leu Cys Thr Gln Asp Lys Thr Pro Ser Val Ser 
            100                 105                 110         


Ser Ile Asn Arg Val Leu Arg Ala Leu Gln Glu Asp Gln Gly Leu Pro 
        115                 120                 125             


Cys Thr Arg Leu Arg Ser Pro Ala Val Leu Ala Pro Ala Val Leu Thr 
    130                 135                 140                 


Pro His Ser Gly Ser Glu Thr Pro Arg Gly Thr His Pro Gly Thr Gly 
145                 150                 155                 160 


His Arg Asn Arg Thr Ile Phe Ser Pro Ser Gln Ala Glu Ala Leu Glu 
                165                 170                 175     


Lys Glu Phe Gln Arg Gly Gln Tyr Pro Asp Ser Val Ala Arg Gly Lys 
            180                 185                 190         


Leu Ala Thr Ala Thr Ser Leu Pro Glu Asp Thr Val Arg Val Trp Phe 
        195                 200                 205             


Ser Asn Arg Arg Ala Lys Trp Arg Arg Gln Glu Lys Leu Lys Trp Glu 
    210                 215                 220                 


Met Gln Leu Pro Gly Ala Ser Gln Gly Leu Thr Val Pro Arg Val Ala 
225                 230                 235                 240 


Pro Gly Ile Ile Ser Ala Gln Gly Pro Thr Val Phe Met Ser Arg Lys 
                245                 250                 255     


Tyr 
    


<210>  10024
<211>  257
<212>  PRT
<213>  Homo Sapiens

<400>  10024

Met Ala Trp Ser Ser Lys Ser Trp Leu Cys Leu Ile Ala Ser Ser Cys 
1               5                   10                  15      


Pro Arg Asp Thr Leu Leu Pro Ser Ala His His Ala Ser Pro Val Pro 
            20                  25                  30          


Ala Ser His Leu Thr Gln Val Ser Asn Gly Cys Val Ser Lys Ile Leu 
        35                  40                  45              


Gly Arg Tyr Tyr Arg Thr Gly Val Leu Glu Pro Lys Gly Ile Gly Gly 
    50                  55                  60                  


Ser Lys Pro Arg Leu Ala Thr Pro Pro Val Val Ala Arg Ile Ala Gln 
65                  70                  75                  80  


Leu Lys Gly Glu Cys Pro Ala Leu Phe Ala Trp Glu Ile Gln Arg Gln 
                85                  90                  95      


Leu Cys Ala Glu Gly Leu Cys Thr Gln Asp Lys Thr Pro Ser Val Ser 
            100                 105                 110         


Ser Ile Asn Arg Val Leu Arg Ala Leu Gln Glu Asp Gln Gly Leu Pro 
        115                 120                 125             


Cys Thr Arg Leu Arg Ser Pro Ala Val Leu Ala Pro Ala Val Leu Thr 
    130                 135                 140                 


Pro His Ser Gly Ser Glu Thr Pro Arg Gly Thr His Pro Gly Thr Gly 
145                 150                 155                 160 


His Arg Asn Arg Thr Ile Phe Ser Pro Ser Gln Ala Glu Ala Leu Glu 
                165                 170                 175     


Lys Glu Phe Gln Arg Gly Gln Tyr Pro Asp Ser Val Ala Arg Gly Lys 
            180                 185                 190         


Leu Ala Thr Ala Thr Ser Leu Pro Glu Asp Thr Val Arg Val Trp Phe 
        195                 200                 205             


Ser Asn Arg Arg Ala Lys Trp Arg Arg Gln Glu Lys Leu Lys Trp Glu 
    210                 215                 220                 


Met Gln Leu Pro Gly Ala Ser Gln Gly Leu Thr Val Pro Arg Val Ala 
225                 230                 235                 240 


Pro Gly Ile Ile Ser Ala Gln Gly Pro Thr Val Phe Met Ser Arg Lys 
                245                 250                 255     


Tyr 
    


<210>  10025
<211>  341
<212>  PRT
<213>  Homo Sapiens

<400>  10025

Met Ala Trp Ser Ser Lys Ser Trp Leu Cys Leu Ile Ala Ser Ser Cys 
1               5                   10                  15      


Pro Arg Asp Thr Leu Leu Pro Ser Ala His His Ala Ser Pro Val Pro 
            20                  25                  30          


Ala Ser His Leu Thr Gln Val Ser Asn Gly Cys Val Ser Lys Ile Leu 
        35                  40                  45              


Gly Arg Tyr Tyr Arg Thr Gly Val Leu Glu Pro Lys Gly Ile Gly Gly 
    50                  55                  60                  


Ser Lys Pro Arg Leu Ala Thr Pro Pro Val Val Ala Arg Ile Ala Gln 
65                  70                  75                  80  


Leu Lys Gly Glu Cys Pro Ala Leu Phe Ala Trp Glu Ile Gln Arg Gln 
                85                  90                  95      


Leu Cys Ala Glu Gly Leu Cys Thr Gln Asp Lys Thr Pro Ser Val Ser 
            100                 105                 110         


Ser Ile Asn Arg Val Leu Arg Ala Leu Gln Glu Asp Gln Gly Leu Pro 
        115                 120                 125             


Cys Thr Arg Leu Arg Ser Pro Ala Val Leu Ala Pro Ala Val Leu Thr 
    130                 135                 140                 


Pro His Ser Gly Ser Glu Thr Pro Arg Gly Thr His Pro Gly Thr Gly 
145                 150                 155                 160 


His Arg Asn Arg Thr Ile Phe Ser Pro Ser Gln Ala Glu Ala Leu Glu 
                165                 170                 175     


Lys Glu Phe Gln Arg Gly Gln Tyr Pro Asp Ser Val Ala Arg Gly Lys 
            180                 185                 190         


Leu Ala Thr Ala Thr Ser Leu Pro Glu Asp Thr Val Arg Val Trp Phe 
        195                 200                 205             


Ser Asn Arg Arg Ala Lys Trp Arg Arg Gln Glu Lys Leu Lys Trp Glu 
    210                 215                 220                 


Met Gln Leu Pro Gly Ala Ser Gln Gly Leu Thr Val Pro Arg Val Ala 
225                 230                 235                 240 


Pro Gly Ile Ile Ser Ala Gln Gln Ser Pro Gly Ser Val Pro Thr Ala 
                245                 250                 255     


Ala Leu Pro Ala Leu Glu Pro Leu Gly Pro Ser Cys Tyr Gln Leu Cys 
            260                 265                 270         


Trp Ala Thr Ala Pro Glu Arg Cys Leu Ser Asp Thr Pro Pro Lys Ala 
        275                 280                 285             


Cys Leu Lys Pro Cys Trp Gly His Leu Pro Pro Gln Pro Asn Ser Leu 
    290                 295                 300                 


Asp Ser Gly Leu Leu Cys Leu Pro Cys Pro Ser Ser His Cys His Leu 
305                 310                 315                 320 


Ala Ser Leu Ser Gly Ser Gln Ala Leu Leu Trp Pro Gly Cys Pro Leu 
                325                 330                 335     


Leu Tyr Gly Leu Glu 
            340     


<210>  10026
<211>  348
<212>  PRT
<213>  Homo Sapiens

<400>  10026

Met His Gln Asp Gly Ile Ser Ser Met Asn Gln Leu Gly Gly Leu Phe 
1               5                   10                  15      


Val Asn Gly Arg Pro Leu Pro Leu Asp Thr Arg Gln Gln Ile Val Arg 
            20                  25                  30          


Leu Ala Val Ser Gly Met Arg Pro Cys Asp Ile Ser Arg Ile Leu Lys 
        35                  40                  45              


Val Ser Asn Gly Cys Val Ser Lys Ile Leu Gly Arg Tyr Tyr Arg Thr 
    50                  55                  60                  


Gly Val Leu Glu Pro Lys Gly Ile Gly Gly Ser Lys Pro Arg Leu Ala 
65                  70                  75                  80  


Thr Pro Pro Val Val Ala Arg Ile Ala Gln Leu Lys Gly Glu Cys Pro 
                85                  90                  95      


Ala Leu Phe Ala Trp Glu Ile Gln Arg Gln Leu Cys Ala Glu Gly Leu 
            100                 105                 110         


Cys Thr Gln Asp Lys Thr Pro Ser Val Ser Ser Ile Asn Arg Val Leu 
        115                 120                 125             


Arg Ala Leu Gln Glu Asp Gln Gly Leu Pro Cys Thr Arg Leu Arg Ser 
    130                 135                 140                 


Pro Ala Val Leu Ala Pro Ala Val Leu Thr Pro His Ser Gly Ser Glu 
145                 150                 155                 160 


Thr Pro Arg Gly Thr His Pro Gly Thr Gly His Arg Asn Arg Thr Ile 
                165                 170                 175     


Phe Ser Pro Ser Gln Ala Glu Ala Leu Glu Lys Glu Phe Gln Arg Gly 
            180                 185                 190         


Gln Tyr Pro Asp Ser Val Ala Arg Gly Lys Leu Ala Thr Ala Thr Ser 
        195                 200                 205             


Leu Pro Glu Asp Thr Val Arg Val Trp Phe Ser Asn Arg Arg Ala Lys 
    210                 215                 220                 


Trp Arg Arg Gln Glu Lys Leu Lys Trp Glu Met Gln Leu Pro Gly Ala 
225                 230                 235                 240 


Ser Gln Gly Leu Thr Val Pro Arg Val Ala Pro Gly Ile Ile Ser Ala 
                245                 250                 255     


Gln Gln Ser Pro Gly Ser Val Pro Thr Ala Ala Leu Pro Ala Leu Glu 
            260                 265                 270         


Pro Leu Gly Pro Ser Cys Tyr Gln Leu Cys Trp Ala Thr Ala Pro Glu 
        275                 280                 285             


Arg Cys Leu Ser Asp Thr Pro Pro Lys Ala Cys Leu Lys Pro Cys Trp 
    290                 295                 300                 


Asp Cys Gly Ser Phe Leu Leu Pro Val Ile Ala Pro Ser Cys Val Asp 
305                 310                 315                 320 


Val Ala Trp Pro Cys Leu Asp Ala Ser Leu Ala His His Leu Ile Gly 
                325                 330                 335     


Gly Ala Gly Lys Ala Thr Pro Thr His Phe Ser His 
            340                 345             


<210>  10027
<211>  349
<212>  PRT
<213>  Homo Sapiens

<400>  10027

Met His Gln Asp Gly Ile Ser Ser Met Asn Gln Leu Gly Gly Leu Phe 
1               5                   10                  15      


Val Asn Gly Arg Pro Leu Pro Leu Asp Thr Arg Gln Gln Ile Val Arg 
            20                  25                  30          


Leu Ala Val Ser Gly Met Arg Pro Cys Asp Ile Ser Arg Ile Leu Lys 
        35                  40                  45              


Val Ser Asn Gly Cys Val Ser Lys Ile Leu Gly Arg Tyr Tyr Arg Thr 
    50                  55                  60                  


Gly Val Leu Glu Pro Lys Gly Ile Gly Gly Ser Lys Pro Arg Leu Ala 
65                  70                  75                  80  


Thr Pro Pro Val Val Ala Arg Ile Ala Gln Leu Lys Gly Glu Cys Pro 
                85                  90                  95      


Ala Leu Phe Ala Trp Glu Ile Gln Arg Gln Leu Cys Ala Glu Gly Leu 
            100                 105                 110         


Cys Thr Gln Asp Lys Thr Pro Ser Val Ser Ser Ile Asn Arg Val Leu 
        115                 120                 125             


Arg Ala Leu Gln Glu Asp Gln Gly Leu Pro Cys Thr Arg Leu Arg Ser 
    130                 135                 140                 


Pro Ala Val Leu Ala Pro Ala Val Leu Thr Pro His Ser Gly Ser Glu 
145                 150                 155                 160 


Thr Pro Arg Gly Thr His Pro Gly Thr Gly His Arg Asn Arg Thr Ile 
                165                 170                 175     


Phe Ser Pro Ser Gln Ala Glu Ala Leu Glu Lys Glu Phe Gln Arg Gly 
            180                 185                 190         


Gln Tyr Pro Asp Ser Val Ala Arg Gly Lys Leu Ala Thr Ala Thr Ser 
        195                 200                 205             


Leu Pro Glu Asp Thr Val Arg Val Trp Phe Ser Asn Arg Arg Ala Lys 
    210                 215                 220                 


Trp Arg Arg Gln Glu Lys Leu Lys Trp Glu Met Gln Leu Pro Gly Ala 
225                 230                 235                 240 


Ser Gln Gly Leu Thr Val Pro Arg Val Ala Pro Gly Ile Ile Ser Ala 
                245                 250                 255     


Gln Gln Ser Pro Gly Ser Val Pro Thr Ala Ala Leu Pro Ala Leu Glu 
            260                 265                 270         


Pro Leu Gly Pro Ser Cys Tyr Gln Leu Cys Trp Ala Thr Ala Pro Glu 
        275                 280                 285             


Arg Cys Leu Ser Asp Thr Pro Pro Lys Ala Cys Leu Lys Pro Cys Trp 
    290                 295                 300                 


Asp Cys Gly Ser Phe Leu Leu Pro Val Ile Ala Pro Ser Cys Val Asp 
305                 310                 315                 320 


Val Ala Trp Pro Cys Leu Asp Ala Ser Leu Ala His His Leu Ile Gly 
                325                 330                 335     


Gly Ala Gly Lys Ala Thr Pro Thr His Phe Ser His Pro 
            340                 345                 


<210>  10028
<211>  351
<212>  PRT
<213>  Homo Sapiens

<400>  10028

Met His Gln Asp Gly Ile Ser Ser Met Asn Gln Leu Gly Gly Leu Phe 
1               5                   10                  15      


Val Asn Gly Arg Pro Leu Pro Leu Asp Thr Arg Gln Gln Ile Val Arg 
            20                  25                  30          


Leu Ala Val Ser Gly Met Arg Pro Cys Asp Ile Ser Arg Ile Leu Lys 
        35                  40                  45              


Val Ser Asn Gly Cys Val Ser Lys Ile Leu Gly Arg Tyr Tyr Arg Thr 
    50                  55                  60                  


Gly Val Leu Glu Pro Lys Gly Ile Gly Gly Ser Lys Pro Arg Leu Ala 
65                  70                  75                  80  


Thr Pro Pro Val Val Ala Arg Ile Ala Gln Leu Lys Gly Glu Cys Pro 
                85                  90                  95      


Ala Leu Phe Ala Trp Glu Ile Gln Arg Gln Leu Cys Ala Glu Gly Leu 
            100                 105                 110         


Cys Thr Gln Asp Lys Thr Pro Ser Val Ser Ser Ile Asn Arg Val Leu 
        115                 120                 125             


Arg Ala Leu Gln Glu Asp Gln Gly Leu Pro Cys Thr Arg Leu Arg Ser 
    130                 135                 140                 


Pro Ala Val Leu Ala Pro Ala Val Leu Thr Pro His Ser Gly Ser Glu 
145                 150                 155                 160 


Thr Pro Arg Gly Thr His Pro Gly Thr Gly His Arg Asn Arg Thr Ile 
                165                 170                 175     


Phe Ser Pro Ser Gln Ala Glu Ala Leu Glu Lys Glu Phe Gln Arg Gly 
            180                 185                 190         


Gln Tyr Pro Asp Ser Val Ala Arg Gly Lys Leu Ala Thr Ala Thr Ser 
        195                 200                 205             


Leu Pro Glu Asp Thr Val Arg Val Trp Phe Ser Asn Arg Arg Ala Lys 
    210                 215                 220                 


Trp Arg Arg Gln Glu Lys Leu Lys Trp Glu Met Gln Leu Pro Gly Ala 
225                 230                 235                 240 


Ser Gln Gly Leu Thr Val Pro Arg Val Ala Pro Gly Ile Ile Ser Ala 
                245                 250                 255     


Gln Gln Ser Pro Gly Ser Val Pro Thr Ala Ala Leu Pro Ala Leu Glu 
            260                 265                 270         


Pro Leu Gly Pro Ser Cys Tyr Gln Leu Cys Trp Ala Thr Ala Pro Glu 
        275                 280                 285             


Arg Cys Leu Ser Asp Thr Pro Pro Lys Ala Cys Leu Lys Pro Cys Trp 
    290                 295                 300                 


Gly His Leu Pro Pro Gln Pro Asn Ser Leu Asp Ser Gly Leu Leu Cys 
305                 310                 315                 320 


Leu Pro Cys Pro Ser Ser His Cys His Leu Ala Ser Leu Ser Gly Ser 
                325                 330                 335     


Gln Ala Leu Leu Trp Pro Gly Cys Pro Leu Leu Tyr Gly Leu Glu 
            340                 345                 350     


<210>  10029
<211>  343
<212>  PRT
<213>  Homo Sapiens

<400>  10029

Met Asn Gln Leu Gly Gly Leu Phe Val Asn Gly Arg Pro Leu Pro Leu 
1               5                   10                  15      


Asp Thr Arg Gln Gln Ile Val Arg Leu Ala Val Ser Gly Met Arg Pro 
            20                  25                  30          


Cys Asp Ile Ser Arg Ile Leu Lys Val Ser Asn Gly Cys Val Ser Lys 
        35                  40                  45              


Ile Leu Gly Arg Tyr Tyr Arg Thr Gly Val Leu Glu Pro Lys Gly Ile 
    50                  55                  60                  


Gly Gly Ser Lys Pro Arg Leu Ala Thr Pro Pro Val Val Ala Arg Ile 
65                  70                  75                  80  


Ala Gln Leu Lys Gly Glu Cys Pro Ala Leu Phe Ala Trp Glu Ile Gln 
                85                  90                  95      


Arg Gln Leu Cys Ala Glu Gly Leu Cys Thr Gln Asp Lys Thr Pro Ser 
            100                 105                 110         


Val Ser Ser Ile Asn Arg Val Leu Arg Ala Leu Gln Glu Asp Gln Gly 
        115                 120                 125             


Leu Pro Cys Thr Arg Leu Arg Ser Pro Ala Val Leu Ala Pro Ala Val 
    130                 135                 140                 


Leu Thr Pro His Ser Gly Ser Glu Thr Pro Arg Gly Thr His Pro Gly 
145                 150                 155                 160 


Thr Gly His Arg Asn Arg Thr Ile Phe Ser Pro Ser Gln Ala Glu Ala 
                165                 170                 175     


Leu Glu Lys Glu Phe Gln Arg Gly Gln Tyr Pro Asp Ser Val Ala Arg 
            180                 185                 190         


Gly Lys Leu Ala Thr Ala Thr Ser Leu Pro Glu Asp Thr Val Arg Val 
        195                 200                 205             


Trp Phe Ser Asn Arg Arg Ala Lys Trp Arg Arg Gln Glu Lys Leu Lys 
    210                 215                 220                 


Trp Glu Met Gln Leu Pro Gly Ala Ser Gln Gly Leu Thr Val Pro Arg 
225                 230                 235                 240 


Val Ala Pro Gly Ile Ile Ser Ala Gln Gln Ser Pro Gly Ser Val Pro 
                245                 250                 255     


Thr Ala Ala Leu Pro Ala Leu Glu Pro Leu Gly Pro Ser Cys Tyr Gln 
            260                 265                 270         


Leu Cys Trp Ala Thr Ala Pro Glu Arg Cys Leu Ser Asp Thr Pro Pro 
        275                 280                 285             


Lys Ala Cys Leu Lys Pro Cys Trp Gly His Leu Pro Pro Gln Pro Asn 
    290                 295                 300                 


Ser Leu Asp Ser Gly Leu Leu Cys Leu Pro Cys Pro Ser Ser His Cys 
305                 310                 315                 320 


His Leu Ala Ser Leu Ser Gly Ser Gln Ala Leu Leu Trp Pro Gly Cys 
                325                 330                 335     


Pro Leu Leu Tyr Gly Leu Glu 
            340             


<210>  10030
<211>  423
<212>  PRT
<213>  Homo Sapiens

<400>  10030

Met Ala Ala Ala Leu Arg Val Ala Ala Val Gly Ala Arg Leu Ser Val 
1               5                   10                  15      


Leu Ala Ser Gly Leu Arg Ala Ala Val Arg Ser Leu Cys Ser Gln Ala 
            20                  25                  30          


Ile Thr Val Gly Ala Pro Val Ile Gly Leu Asn Asp Ser Gly Gly Ala 
        35                  40                  45              


Arg Ile Gln Glu Gly Val Glu Ser Leu Ala Gly Tyr Ala Asp Ile Phe 
    50                  55                  60                  


Leu Arg Asn Val Thr Ala Ser Gly Val Ile Pro Gln Ile Ser Leu Ile 
65                  70                  75                  80  


Met Gly Pro Cys Ala Gly Gly Ala Val Tyr Ser Pro Ala Leu Thr Asp 
                85                  90                  95      


Phe Thr Phe Met Val Lys Asp Thr Ser Tyr Leu Phe Ile Thr Gly Pro 
            100                 105                 110         


Asp Val Val Lys Ser Val Thr Asn Glu Asp Val Thr Gln Glu Glu Leu 
        115                 120                 125             


Gly Gly Ala Lys Thr His Thr Thr Met Ser Gly Val Ala His Arg Ala 
    130                 135                 140                 


Phe Glu Asn Asp Val Asp Ala Leu Cys Asn Leu Arg Asp Phe Phe Asn 
145                 150                 155                 160 


Tyr Leu Pro Leu Ser Ser Gln Asp Pro Ala Pro Val Arg Glu Cys His 
                165                 170                 175     


Asp Pro Ser Asp Arg Leu Val Pro Glu Leu Asp Thr Ile Val Pro Leu 
            180                 185                 190         


Glu Ser Thr Lys Ala Tyr Asn Met Val Asp Ile Ile His Ser Val Val 
        195                 200                 205             


Asp Glu Arg Glu Phe Phe Glu Ile Met Pro Asn Tyr Ala Lys Asn Ile 
    210                 215                 220                 


Ile Val Gly Phe Ala Arg Met Asn Gly Arg Thr Val Gly Ile Val Gly 
225                 230                 235                 240 


Asn Gln Pro Lys Val Ala Ser Gly Cys Leu Asp Ile Asn Ser Ser Val 
                245                 250                 255     


Lys Gly Ala Arg Phe Val Arg Phe Cys Asp Ala Phe Asn Ile Pro Leu 
            260                 265                 270         


Ile Thr Phe Val Asp Val Pro Gly Phe Leu Pro Gly Thr Ala Gln Glu 
        275                 280                 285             


Tyr Gly Gly Ile Ile Arg His Gly Ala Lys Leu Leu Tyr Ala Phe Ala 
    290                 295                 300                 


Glu Ala Thr Val Pro Lys Val Thr Val Ile Thr Arg Lys Ala Tyr Gly 
305                 310                 315                 320 


Gly Ala Tyr Asp Val Met Ser Ser Lys His Leu Cys Gly Asp Thr Asn 
                325                 330                 335     


Tyr Ala Trp Pro Thr Ala Glu Ile Ala Val Met Gly Ala Lys Gly Ala 
            340                 345                 350         


Val Glu Ile Ile Phe Lys Gly His Glu Asn Val Glu Ala Ala Gln Ala 
        355                 360                 365             


Glu Tyr Ile Glu Lys Phe Ala Asn Pro Phe Pro Ala Ala Val Arg Gly 
    370                 375                 380                 


Phe Val Asp Asp Ile Ile Gln Pro Ser Ser Thr Arg Ala Arg Ile Cys 
385                 390                 395                 400 


Cys Asp Leu Asp Val Leu Ala Ser Lys Lys Val Gln Arg Pro Trp Arg 
                405                 410                 415     


Lys His Ala Asn Ile Pro Leu 
            420             


<210>  10031
<211>  192
<212>  PRT
<213>  Homo Sapiens

<400>  10031

Met Ala Ala Ala Leu Arg Val Ala Ala Val Gly Ala Arg Leu Ser Val 
1               5                   10                  15      


Leu Ala Ser Gly Leu Arg Ala Ala Val Arg Ser Leu Cys Ser Gln Ala 
            20                  25                  30          


Thr Ser Val Asn Glu Arg Ile Glu Asn Lys Arg Arg Thr Ala Leu Leu 
        35                  40                  45              


Gly Gly Gly Gln Arg Arg Ile Asp Ala Gln His Lys Arg Ala Arg Val 
    50                  55                  60                  


Gln Gln Leu Thr Ala Thr Ser Ala Ser Gln Leu Gln Ala Ile Leu Leu 
65                  70                  75                  80  


Pro Gln Pro Pro Glu Tyr Leu Gly Leu Gln Gly Lys Leu Thr Ala Arg 
                85                  90                  95      


Glu Arg Ile Ser Leu Leu Leu Asp Pro Gly Ser Phe Val Glu Ser Asp 
            100                 105                 110         


Met Phe Val Glu His Arg Cys Ala Asp Phe Gly Met Ala Ala Asp Lys 
        115                 120                 125             


Asn Lys Phe Pro Gly Asp Ser Val Val Thr Gly Arg Gly Arg Ile Asn 
    130                 135                 140                 


Gly Arg Leu Val Tyr Val Phe Ser Gln Asp Phe Thr Val Phe Gly Gly 
145                 150                 155                 160 


Ser Leu Ser Gly Ala His Ala Gln Lys Ile Cys Lys Ile Met Asp Gln 
                165                 170                 175     


Ala Ile Thr Val Gly Ala Pro Val Ile Gly Leu Asn Asp Ser Gly Gly 
            180                 185                 190         


<210>  10032
<211>  516
<212>  PRT
<213>  Homo Sapiens

<400>  10032

Met Ala Ala Ala Leu Arg Val Ala Ala Val Gly Ala Arg Leu Ser Val 
1               5                   10                  15      


Leu Ala Ser Gly Leu Arg Ala Ala Val Arg Ser Leu Cys Ser Gln Ala 
            20                  25                  30          


Thr Ser Val Asn Glu Arg Ile Glu Asn Lys Arg Arg Thr Ala Leu Leu 
        35                  40                  45              


Gly Gly Gly Gln Arg Arg Ile Asp Ala Gln His Lys Arg Gly Lys Leu 
    50                  55                  60                  


Thr Ala Arg Glu Arg Ile Ser Leu Leu Leu Asp Pro Gly Ser Phe Val 
65                  70                  75                  80  


Glu Ser Asp Met Phe Val Glu His Arg Cys Ala Asp Phe Gly Met Ala 
                85                  90                  95      


Ala Asp Lys Asn Lys Asp Phe Thr Val Phe Gly Gly Ser Leu Ser Gly 
            100                 105                 110         


Ala His Ala Gln Lys Ile Cys Lys Ile Met Asp Gln Ala Ile Thr Val 
        115                 120                 125             


Gly Ala Pro Val Ile Gly Leu Asn Asp Ser Gly Gly Ala Arg Ile Gln 
    130                 135                 140                 


Glu Gly Val Glu Ser Leu Ala Gly Tyr Ala Asp Ile Phe Leu Arg Asn 
145                 150                 155                 160 


Val Thr Ala Ser Gly Val Ile Pro Gln Ile Ser Leu Ile Met Gly Pro 
                165                 170                 175     


Cys Ala Gly Gly Ala Val Tyr Ser Pro Ala Leu Thr Asp Phe Thr Phe 
            180                 185                 190         


Met Val Lys Asp Thr Ser Tyr Leu Phe Ile Thr Gly Pro Asp Val Val 
        195                 200                 205             


Lys Ser Val Thr Asn Glu Asp Val Thr Gln Glu Glu Leu Gly Gly Ala 
    210                 215                 220                 


Lys Thr His Thr Thr Met Ser Gly Val Ala His Arg Ala Phe Glu Asn 
225                 230                 235                 240 


Asp Val Asp Ala Leu Cys Asn Leu Arg Asp Phe Phe Asn Tyr Leu Pro 
                245                 250                 255     


Leu Ser Ser Gln Asp Pro Ala Pro Val Arg Glu Cys His Asp Pro Ser 
            260                 265                 270         


Asp Arg Leu Val Pro Glu Leu Asp Thr Ile Val Pro Leu Glu Ser Thr 
        275                 280                 285             


Lys Ala Tyr Asn Met Val Asp Ile Ile His Ser Val Val Asp Glu Arg 
    290                 295                 300                 


Glu Phe Phe Glu Ile Met Pro Asn Tyr Ala Lys Asn Ile Ile Val Gly 
305                 310                 315                 320 


Phe Ala Arg Met Asn Gly Arg Thr Val Gly Ile Val Gly Asn Gln Pro 
                325                 330                 335     


Lys Val Ala Ser Gly Cys Leu Asp Ile Asn Ser Ser Val Lys Gly Ala 
            340                 345                 350         


Arg Phe Val Arg Phe Cys Asp Ala Phe Asn Ile Pro Leu Ile Thr Phe 
        355                 360                 365             


Val Asp Val Pro Gly Phe Leu Pro Gly Thr Ala Gln Glu Tyr Gly Gly 
    370                 375                 380                 


Ile Ile Arg His Gly Ala Lys Leu Leu Tyr Ala Phe Ala Glu Ala Thr 
385                 390                 395                 400 


Val Pro Lys Val Thr Val Ile Thr Arg Lys Ala Tyr Gly Gly Ala Tyr 
                405                 410                 415     


Asp Val Met Ser Ser Lys His Leu Cys Gly Asp Thr Asn Tyr Ala Trp 
            420                 425                 430         


Pro Thr Ala Glu Ile Ala Val Met Gly Ala Lys Gly Ala Val Glu Ile 
        435                 440                 445             


Ile Phe Lys Gly His Glu Asn Val Glu Ala Ala Gln Ala Glu Tyr Ile 
    450                 455                 460                 


Glu Lys Phe Ala Asn Pro Phe Pro Ala Ala Val Arg Gly Phe Val Asp 
465                 470                 475                 480 


Asp Ile Ile Gln Pro Ser Ser Thr Arg Ala Arg Ile Cys Cys Asp Leu 
                485                 490                 495     


Asp Val Leu Ala Ser Lys Lys Val Gln Arg Pro Trp Arg Lys His Ala 
            500                 505                 510         


Asn Ile Pro Leu 
        515     


<210>  10033
<211>  539
<212>  PRT
<213>  Homo Sapiens

<400>  10033

Met Ala Ala Ala Leu Arg Val Ala Ala Val Gly Ala Arg Leu Ser Val 
1               5                   10                  15      


Leu Ala Ser Gly Leu Arg Ala Ala Val Arg Ser Leu Cys Ser Gln Ala 
            20                  25                  30          


Thr Ser Val Asn Glu Arg Ile Glu Asn Lys Arg Arg Thr Ala Leu Leu 
        35                  40                  45              


Gly Gly Gly Gln Arg Arg Ile Asp Ala Gln His Lys Arg Gly Lys Leu 
    50                  55                  60                  


Thr Ala Arg Glu Arg Ile Ser Leu Leu Leu Asp Pro Gly Ser Phe Val 
65                  70                  75                  80  


Glu Ser Asp Met Phe Val Glu His Arg Cys Ala Asp Phe Gly Met Ala 
                85                  90                  95      


Ala Asp Lys Asn Lys Phe Pro Gly Asp Ser Val Val Thr Gly Arg Gly 
            100                 105                 110         


Arg Ile Asn Gly Arg Leu Val Tyr Val Phe Ser Gln Asp Phe Thr Val 
        115                 120                 125             


Phe Gly Gly Ser Leu Ser Gly Ala His Ala Gln Lys Ile Cys Lys Ile 
    130                 135                 140                 


Met Asp Gln Ala Ile Thr Val Gly Ala Pro Val Ile Gly Leu Asn Asp 
145                 150                 155                 160 


Ser Gly Gly Ala Arg Ile Gln Glu Gly Val Glu Ser Leu Ala Gly Tyr 
                165                 170                 175     


Ala Asp Ile Phe Leu Arg Asn Val Thr Ala Ser Gly Val Ile Pro Gln 
            180                 185                 190         


Ile Ser Leu Ile Met Gly Pro Cys Ala Gly Gly Ala Val Tyr Ser Pro 
        195                 200                 205             


Ala Leu Thr Asp Phe Thr Phe Met Val Lys Asp Thr Ser Tyr Leu Phe 
    210                 215                 220                 


Ile Thr Gly Pro Asp Val Val Lys Ser Val Thr Asn Glu Asp Val Thr 
225                 230                 235                 240 


Gln Glu Glu Leu Gly Gly Ala Lys Thr His Thr Thr Met Ser Gly Val 
                245                 250                 255     


Ala His Arg Ala Phe Glu Asn Asp Val Asp Ala Leu Cys Asn Leu Arg 
            260                 265                 270         


Asp Phe Phe Asn Tyr Leu Pro Leu Ser Ser Gln Asp Pro Ala Pro Val 
        275                 280                 285             


Arg Glu Cys His Asp Pro Ser Asp Arg Leu Val Pro Glu Leu Asp Thr 
    290                 295                 300                 


Ile Val Pro Leu Glu Ser Thr Lys Ala Tyr Asn Met Val Asp Ile Ile 
305                 310                 315                 320 


His Ser Val Val Asp Glu Arg Glu Phe Phe Glu Ile Met Pro Asn Tyr 
                325                 330                 335     


Ala Lys Asn Ile Ile Val Gly Phe Ala Arg Met Asn Gly Arg Thr Val 
            340                 345                 350         


Gly Ile Val Gly Asn Gln Pro Lys Val Ala Ser Gly Cys Leu Asp Ile 
        355                 360                 365             


Asn Ser Ser Val Lys Gly Ala Arg Phe Val Arg Phe Cys Asp Ala Phe 
    370                 375                 380                 


Asn Ile Pro Leu Ile Thr Phe Val Asp Val Pro Gly Phe Leu Pro Gly 
385                 390                 395                 400 


Thr Ala Gln Glu Tyr Gly Gly Ile Ile Arg His Gly Ala Lys Leu Leu 
                405                 410                 415     


Tyr Ala Phe Ala Glu Ala Thr Val Pro Lys Val Thr Val Ile Thr Arg 
            420                 425                 430         


Lys Ala Tyr Gly Gly Ala Tyr Asp Val Met Ser Ser Lys His Leu Cys 
        435                 440                 445             


Gly Asp Thr Asn Tyr Ala Trp Pro Thr Ala Glu Ile Ala Val Met Gly 
    450                 455                 460                 


Ala Lys Gly Ala Val Glu Ile Ile Phe Lys Gly His Glu Asn Val Glu 
465                 470                 475                 480 


Ala Ala Gln Ala Glu Tyr Ile Glu Lys Phe Ala Asn Pro Phe Pro Ala 
                485                 490                 495     


Ala Val Arg Gly Phe Val Asp Asp Ile Ile Gln Pro Ser Ser Thr Arg 
            500                 505                 510         


Ala Arg Ile Cys Cys Asp Leu Asp Val Leu Ala Ser Lys Lys Val Gln 
        515                 520                 525             


Arg Pro Trp Arg Lys His Ala Asn Ile Pro Leu 
    530                 535                 


<210>  10034
<211>  559
<212>  PRT
<213>  Homo Sapiens

<400>  10034

Met Ala Ala Ala Leu Arg Val Ala Ala Val Gly Ala Arg Leu Ser Val 
1               5                   10                  15      


Leu Ala Ser Gly Leu Arg Ala Ala Val Arg Ser Leu Cys Ser Gln Ala 
            20                  25                  30          


Thr Ser Val Asn Glu Arg Ile Glu Asn Lys Arg Arg Thr Ala Leu Leu 
        35                  40                  45              


Gly Gly Gly Gln Arg Arg Ile Asp Ala Gln His Lys Arg Gly Lys Leu 
    50                  55                  60                  


Thr Ala Arg Glu Arg Ile Ser Leu Leu Leu Asp Pro Gly Ser Phe Val 
65                  70                  75                  80  


Glu Ser Asp Met Phe Val Glu His Arg Cys Ala Asp Phe Gly Met Ala 
                85                  90                  95      


Ala Asp Lys Asn Lys Phe Pro Gly Asp Ser Val Val Thr Gly Arg Gly 
            100                 105                 110         


Arg Ile Asn Gly Arg Leu Val Tyr Val Phe Ser Gln Asp Phe Thr Val 
        115                 120                 125             


Phe Gly Gly Ser Leu Ser Gly Ala His Ala Gln Lys Ile Cys Lys Ile 
    130                 135                 140                 


Met Asp Gln Ala Ile Thr Val Gly Ala Pro Val Ile Gly Leu Asn Asp 
145                 150                 155                 160 


Ser Gly Gly Ala Arg Ile Gln Glu Gly Val Glu Ser Leu Ala Gly Tyr 
                165                 170                 175     


Ala Asp Ile Phe Leu Arg Asn Val Thr Ala Ser Gly Val Ile Pro Gln 
            180                 185                 190         


Ile Ser Leu Ile Met Gly Pro Cys Ala Gly Gly Ala Val Tyr Ser Pro 
        195                 200                 205             


Ala Leu Thr Asp Phe Thr Phe Met Val Lys Asp Thr Ser Tyr Leu Phe 
    210                 215                 220                 


Ile Thr Gly Pro Asp Val Val Lys Ser Val Thr Asn Glu Asp Val Thr 
225                 230                 235                 240 


Gln Glu Glu Leu Gly Gly Ala Lys Thr His Thr Thr Met Ser Gly Val 
                245                 250                 255     


Ala His Arg Ala Phe Glu Asn Asp Val Asp Ala Leu Cys Asn Leu Arg 
            260                 265                 270         


Asp Phe Phe Asn Tyr Leu Pro Leu Ser Ser Gln Asp Pro Ala Pro Val 
        275                 280                 285             


Arg Glu Cys His Asp Pro Ser Asp Arg Leu Val Pro Glu Leu Asp Thr 
    290                 295                 300                 


Ile Val Pro Leu Glu Ser Thr Lys Ala Tyr Asn Met Val Asp Ile Ile 
305                 310                 315                 320 


His Ser Val Val Asp Glu Arg Glu Phe Phe Glu Ile Met Pro Asn Tyr 
                325                 330                 335     


Ala Lys Asn Ile Ile Val Gly Phe Ala Arg Met Asn Gly Arg Thr Val 
            340                 345                 350         


Gly Ile Val Gly Asn Gln Pro Lys Val Ala Ser Asp Ser Ile Ser Phe 
        355                 360                 365             


Thr Pro Trp Asn Tyr Ala Arg Arg Gln Tyr Arg Pro Tyr Phe Ala Gly 
    370                 375                 380                 


Cys Leu Asp Ile Asn Ser Ser Val Lys Gly Ala Arg Phe Val Arg Phe 
385                 390                 395                 400 


Cys Asp Ala Phe Asn Ile Pro Leu Ile Thr Phe Val Asp Val Pro Gly 
                405                 410                 415     


Phe Leu Pro Gly Thr Ala Gln Glu Tyr Gly Gly Ile Ile Arg His Gly 
            420                 425                 430         


Ala Lys Leu Leu Tyr Ala Phe Ala Glu Ala Thr Val Pro Lys Val Thr 
        435                 440                 445             


Val Ile Thr Arg Lys Ala Tyr Gly Gly Ala Tyr Asp Val Met Ser Ser 
    450                 455                 460                 


Lys His Leu Cys Gly Asp Thr Asn Tyr Ala Trp Pro Thr Ala Glu Ile 
465                 470                 475                 480 


Ala Val Met Gly Ala Lys Gly Ala Val Glu Ile Ile Phe Lys Gly His 
                485                 490                 495     


Glu Asn Val Glu Ala Ala Gln Ala Glu Tyr Ile Glu Lys Phe Ala Asn 
            500                 505                 510         


Pro Phe Pro Ala Ala Val Arg Gly Phe Val Asp Asp Ile Ile Gln Pro 
        515                 520                 525             


Ser Ser Thr Arg Ala Arg Ile Cys Cys Asp Leu Asp Val Leu Ala Ser 
    530                 535                 540                 


Lys Lys Val Gln Arg Pro Trp Arg Lys His Ala Asn Ile Pro Leu 
545                 550                 555                 


<210>  10035
<211>  303
<212>  PRT
<213>  Homo Sapiens

<400>  10035

Met Ala Ala Ala Leu Arg Val Ala Ala Val Gly Ala Arg Leu Ser Val 
1               5                   10                  15      


Leu Ala Ser Gly Leu Arg Ala Ala Val Arg Ser Leu Cys Ser Gln Ala 
            20                  25                  30          


Thr Ser Val Asn Glu Arg Ile Glu Asn Lys Arg Arg Thr Ala Leu Leu 
        35                  40                  45              


Gly Gly Gly Gln Arg Arg Ile Asp Ala Gln His Lys Arg Gly Lys Leu 
    50                  55                  60                  


Thr Ala Arg Glu Arg Ile Ser Leu Leu Leu Asp Pro Gly Ser Phe Val 
65                  70                  75                  80  


Glu Ser Asp Met Phe Val Glu His Arg Cys Ala Asp Phe Gly Met Ala 
                85                  90                  95      


Ala Asp Lys Asn Lys Phe Pro Gly Asp Ser Val Val Thr Gly Arg Gly 
            100                 105                 110         


Arg Ile Asn Gly Arg Leu Val Tyr Val Phe Ser Gln Asp Phe Thr Val 
        115                 120                 125             


Phe Gly Gly Ser Leu Ser Gly Ala His Ala Gln Lys Ile Cys Lys Ile 
    130                 135                 140                 


Met Asp Gln Ala Ile Thr Val Gly Ala Pro Val Ile Gly Leu Asn Asp 
145                 150                 155                 160 


Ser Gly Gly Ala Arg Ile Gln Glu Gly Val Glu Ser Leu Ala Gly Tyr 
                165                 170                 175     


Ala Asp Ile Phe Leu Arg Asn Val Thr Ala Ser Gly Val Ile Pro Gln 
            180                 185                 190         


Ile Ser Leu Ile Met Gly Pro Cys Ala Gly Gly Ala Val Tyr Ser Pro 
        195                 200                 205             


Ala Leu Thr Asp Phe Thr Phe Met Val Lys Asp Thr Ser Tyr Leu Phe 
    210                 215                 220                 


Ile Thr Gly Pro Asp Val Val Lys Ser Val Thr Asn Glu Asp Val Thr 
225                 230                 235                 240 


Gln Glu Glu Leu Gly Gly Ala Lys Thr His Thr Thr Met Ser Gly Val 
                245                 250                 255     


Ala His Arg Ala Phe Glu Asn Asp Val Asp Ala Leu Cys Asn Leu Arg 
            260                 265                 270         


Asp Phe Phe Asn Tyr Leu Pro Leu Ser Ser Gln Asp Pro Ala Pro Val 
        275                 280                 285             


Arg Glu Cys His Asp Pro Ser Pro Thr Phe Cys Leu Trp Leu His 
    290                 295                 300             


<210>  10036
<211>  550
<212>  PRT
<213>  Homo Sapiens

<400>  10036

Met Ala Ala Ala Leu Arg Val Ala Ala Val Gly Ala Arg Leu Ser Val 
1               5                   10                  15      


Leu Ala Ser Gly Leu Arg Ala Ala Val Arg Ser Leu Cys Ser Gln Ala 
            20                  25                  30          


Thr Ser Val Asn Glu Arg Ile Glu Asn Lys Arg Arg Thr Ala Leu Leu 
        35                  40                  45              


Gly Gly Gly Gln Arg Arg Ile Asp Ala Gln His Lys Arg Gly Lys Leu 
    50                  55                  60                  


Thr Ala Arg Glu Arg Ile Ser Leu Leu Leu Asp Pro Gly Ser Phe Val 
65                  70                  75                  80  


Glu Ser Asp Met Phe Val Glu His Arg Cys Ala Asp Phe Gly Met Ala 
                85                  90                  95      


Ala Asp Lys Asn Lys Phe Pro Gly Asp Ser Val Val Thr Gly Arg Gly 
            100                 105                 110         


Arg Ile Asn Gly Arg Leu Val Tyr Val Phe Ser Gln Asp Phe Thr Val 
        115                 120                 125             


Phe Gly Gly Ser Leu Ser Gly Ala His Ala Gln Lys Ile Cys Lys Ile 
    130                 135                 140                 


Met Asp Gln Ala Ile Thr Val Gly Ala Pro Val Ile Gly Leu Asn Asp 
145                 150                 155                 160 


Ser Gly Gly Ala Arg Ile Gln Glu Gly Val Glu Ser Leu Ala Gly Tyr 
                165                 170                 175     


Ala Asp Ile Phe Leu Arg Asn Val Thr Ala Ser Gly Val Ile Pro Gln 
            180                 185                 190         


Ile Ser Leu Ile Met Gly Pro Cys Ala Gly Gly Ala Val Tyr Ser Pro 
        195                 200                 205             


Ala Leu Thr Asp Phe Thr Phe Met Val Lys Asp Thr Ser Tyr Leu Phe 
    210                 215                 220                 


Ile Thr Gly Pro Asp Val Val Lys Ser Val Thr Asn Glu Asp Val Thr 
225                 230                 235                 240 


Gln Glu Glu Leu Gly Gly Ala Lys Thr His Thr Thr Met Ser Gly Val 
                245                 250                 255     


Ala His Arg Ala Phe Glu Asn Asp Val Asp Ala Leu Cys Asn Leu Arg 
            260                 265                 270         


Asp Phe Phe Asn Tyr Leu Pro Leu Ser Ser Gln Asp Pro Ala Pro Val 
        275                 280                 285             


Arg Glu Cys His Asp Pro Ser Asp Arg Leu Val Pro Glu Leu Asp Thr 
    290                 295                 300                 


Ile Val Pro Leu Glu Ser Thr Lys Ala Tyr Asn Met Val Asp Ile Ile 
305                 310                 315                 320 


His Ser Val Val Asp Glu Arg Glu Phe Phe Glu Ile Met Pro Asn Tyr 
                325                 330                 335     


Ala Lys Asn Ile Ile Val Gly Phe Ala Arg Met Asn Gly Arg Thr Val 
            340                 345                 350         


Gly Ile Val Gly Asn Gln Pro Lys Val Ala Ser Gly Cys Leu Asp Ile 
        355                 360                 365             


Asn Ser Ser Val Lys Gly Ala Arg Phe Val Arg Phe Cys Asp Ala Phe 
    370                 375                 380                 


Asn Ile Pro Leu Ile Thr Phe Val Asp Val Pro Gly Phe Leu Pro Gly 
385                 390                 395                 400 


Thr Ala Gln Glu Tyr Gly Gly Ile Ile Arg His Gly Ala Lys Leu Leu 
                405                 410                 415     


Tyr Ala Phe Ala Glu Ala Thr Val Pro Lys Val Thr Val Ile Thr Arg 
            420                 425                 430         


Lys Ala Tyr Gly Gly Ala Tyr Asp Val Met Ser Ser Lys His Leu Cys 
        435                 440                 445             


Gly Asp Thr Asn Tyr Ala Trp Pro Thr Ala Glu Ile Ala Val Met Gly 
    450                 455                 460                 


Ala Lys Gly Ala Val Glu Ile Ile Phe Lys Gly His Glu Asn Val Glu 
465                 470                 475                 480 


Ala Ala Gln Ala Glu Tyr Ile Glu Lys Phe Ala Asn Pro Phe Pro Ala 
                485                 490                 495     


Ala Val Arg Gly Phe Val Asp Asp Ile Ile Gln Pro Ser Ser Thr Arg 
            500                 505                 510         


Ala Arg Ile Cys Cys Asp Leu Asp Val Leu Ala Ser Lys Lys Val Arg 
        515                 520                 525             


Val Gln Glu Val Phe His Gln Val Val Gln Ser Gly His Arg Asp Gly 
    530                 535                 540                 


Arg Gly Ala Val Arg Trp 
545                 550 


<210>  10037
<211>  405
<212>  PRT
<213>  Homo Sapiens

<400>  10037

Met Ala Ala Ala Leu Arg Val Ala Ala Val Gly Ala Arg Leu Ser Val 
1               5                   10                  15      


Leu Ala Ser Gly Leu Arg Ala Ala Val Arg Ser Leu Cys Ser Gln Ala 
            20                  25                  30          


Thr Ser Val Asn Glu Arg Ile Glu Asn Lys Arg Arg Thr Ala Leu Leu 
        35                  40                  45              


Gly Gly Gly Gln Arg Arg Ile Asp Ala Gln His Lys Arg Gly Lys Leu 
    50                  55                  60                  


Thr Ala Arg Glu Arg Ile Ser Leu Leu Leu Asp Pro Gly Ser Phe Val 
65                  70                  75                  80  


Glu Ser Asp Met Phe Val Glu His Arg Cys Ala Asp Phe Gly Met Ala 
                85                  90                  95      


Ala Asp Lys Asn Lys Phe Pro Gly Asp Ser Val Val Thr Gly Arg Gly 
            100                 105                 110         


Arg Ile Asn Gly Arg Leu Val Tyr Val Phe Ser Gln Asp Phe Thr Val 
        115                 120                 125             


Phe Gly Gly Ser Leu Ser Gly Ala His Ala Gln Lys Ile Cys Lys Ile 
    130                 135                 140                 


Met Asp Gln Ala Ile Thr Val Gly Ala Pro Val Ile Gly Leu Asn Asp 
145                 150                 155                 160 


Ser Gly Gly Ala Arg Ile Gln Glu Gly Val Glu Ser Leu Ala Gly Tyr 
                165                 170                 175     


Ala Asp Ile Phe Leu Arg Asn Val Thr Ala Ser Gly Val Ile Pro Gln 
            180                 185                 190         


Ile Ser Leu Ile Met Gly Pro Cys Ala Gly Gly Ala Val Tyr Ser Pro 
        195                 200                 205             


Ala Leu Thr Asp Phe Thr Phe Met Val Lys Asp Thr Ser Tyr Leu Phe 
    210                 215                 220                 


Ile Thr Gly Pro Asp Val Val Lys Ser Val Thr Asn Glu Asp Val Thr 
225                 230                 235                 240 


Gln Glu Glu Leu Gly Gly Ala Lys Thr His Thr Thr Met Ser Gly Val 
                245                 250                 255     


Ala His Arg Ala Phe Glu Asn Asp Val Asp Ala Leu Cys Asn Leu Arg 
            260                 265                 270         


Asp Phe Phe Asn Tyr Leu Pro Leu Ser Ser Gln Asp Pro Ala Pro Val 
        275                 280                 285             


Arg Glu Cys His Asp Pro Ser Asp Arg Leu Val Pro Glu Leu Asp Thr 
    290                 295                 300                 


Ile Val Pro Leu Glu Ser Thr Lys Ala Tyr Asn Met Val Asp Ile Ile 
305                 310                 315                 320 


His Ser Val Val Asp Glu Arg Glu Phe Phe Glu Ile Met Pro Asn Tyr 
                325                 330                 335     


Ala Lys Asn Ile Ile Val Gly Phe Ala Arg Met Asn Gly Arg Thr Val 
            340                 345                 350         


Gly Ile Val Gly Asn Gln Pro Lys Val Ala Ser Gly Cys Leu Asp Ile 
        355                 360                 365             


Asn Ser Ser Val Lys Gly Ala Arg Phe Val Arg Phe Cys Asp Ala Phe 
    370                 375                 380                 


Asn Ile Pro Leu Ile Thr Phe Val Asp Val Pro Gly Phe Leu Pro Gly 
385                 390                 395                 400 


Leu Trp Arg Cys Leu 
                405 


<210>  10038
<211>  520
<212>  PRT
<213>  Homo Sapiens

<400>  10038

Met Ala Ala Ala Leu Arg Val Ala Ala Val Gly Ala Arg Leu Ser Val 
1               5                   10                  15      


Leu Ala Ser Gly Leu Arg Ala Ala Val Arg Ser Leu Cys Ser Gln Ala 
            20                  25                  30          


Thr Ser Val Asn Glu Arg Ile Glu Asn Lys Arg Arg Thr Ala Leu Leu 
        35                  40                  45              


Gly Gly Gly Gln Arg Arg Ile Asp Ala Gln His Lys Arg Gly Lys Leu 
    50                  55                  60                  


Thr Ala Arg Glu Arg Ile Ser Leu Leu Leu Asp Pro Gly Ser Phe Val 
65                  70                  75                  80  


Glu Ser Asp Met Phe Val Glu His Arg Cys Ala Asp Phe Gly Met Ala 
                85                  90                  95      


Ala Asp Lys Asn Lys Phe Pro Gly Asp Ser Val Val Thr Gly Arg Gly 
            100                 105                 110         


Arg Ile Asn Gly Arg Leu Val Tyr Val Phe Ser Gln Ile Met Asp Gln 
        115                 120                 125             


Ala Ile Thr Val Gly Ala Pro Val Ile Gly Leu Asn Asp Ser Gly Gly 
    130                 135                 140                 


Ala Arg Ile Gln Glu Gly Val Glu Ser Leu Ala Gly Tyr Ala Asp Ile 
145                 150                 155                 160 


Phe Leu Arg Asn Val Thr Ala Ser Gly Val Ile Pro Gln Ile Ser Leu 
                165                 170                 175     


Ile Met Gly Pro Cys Ala Gly Gly Ala Val Tyr Ser Pro Ala Leu Thr 
            180                 185                 190         


Asp Phe Thr Phe Met Val Lys Asp Thr Ser Tyr Leu Phe Ile Thr Gly 
        195                 200                 205             


Pro Asp Val Val Lys Ser Val Thr Asn Glu Asp Val Thr Gln Glu Glu 
    210                 215                 220                 


Leu Gly Gly Ala Lys Thr His Thr Thr Met Ser Gly Val Ala His Arg 
225                 230                 235                 240 


Ala Phe Glu Asn Asp Val Asp Ala Leu Cys Asn Leu Arg Asp Phe Phe 
                245                 250                 255     


Asn Tyr Leu Pro Leu Ser Ser Gln Asp Pro Ala Pro Val Arg Glu Cys 
            260                 265                 270         


His Asp Pro Ser Asp Arg Leu Val Pro Glu Leu Asp Thr Ile Val Pro 
        275                 280                 285             


Leu Glu Ser Thr Lys Ala Tyr Asn Met Val Asp Ile Ile His Ser Val 
    290                 295                 300                 


Val Asp Glu Arg Glu Phe Phe Glu Ile Met Pro Asn Tyr Ala Lys Asn 
305                 310                 315                 320 


Ile Ile Val Gly Phe Ala Arg Met Asn Gly Arg Thr Val Gly Ile Val 
                325                 330                 335     


Gly Asn Gln Pro Lys Val Ala Ser Gly Cys Leu Asp Ile Asn Ser Ser 
            340                 345                 350         


Val Lys Gly Ala Arg Phe Val Arg Phe Cys Asp Ala Phe Asn Ile Pro 
        355                 360                 365             


Leu Ile Thr Phe Val Asp Val Pro Gly Phe Leu Pro Gly Thr Ala Gln 
    370                 375                 380                 


Glu Tyr Gly Gly Ile Ile Arg His Gly Ala Lys Leu Leu Tyr Ala Phe 
385                 390                 395                 400 


Ala Glu Ala Thr Val Pro Lys Val Thr Val Ile Thr Arg Lys Ala Tyr 
                405                 410                 415     


Gly Gly Ala Tyr Asp Val Met Ser Ser Lys His Leu Cys Gly Asp Thr 
            420                 425                 430         


Asn Tyr Ala Trp Pro Thr Ala Glu Ile Ala Val Met Gly Ala Lys Gly 
        435                 440                 445             


Ala Val Glu Ile Ile Phe Lys Gly His Glu Asn Val Glu Ala Ala Gln 
    450                 455                 460                 


Ala Glu Tyr Ile Glu Lys Phe Ala Asn Pro Phe Pro Ala Ala Val Arg 
465                 470                 475                 480 


Gly Phe Val Asp Asp Ile Ile Gln Pro Ser Ser Thr Arg Ala Arg Ile 
                485                 490                 495     


Cys Cys Asp Leu Asp Val Leu Ala Ser Lys Lys Val Gln Arg Pro Trp 
            500                 505                 510         


Arg Lys His Ala Asn Ile Pro Leu 
        515                 520 


<210>  10039
<211>  570
<212>  PRT
<213>  Homo Sapiens

<400>  10039

Met Ala Ala Ala Leu Arg Val Ala Ala Val Gly Ala Arg Leu Ser Val 
1               5                   10                  15      


Leu Ala Ser Gly Leu Arg Ala Ala Val Arg Ser Leu Cys Ser Gln Ala 
            20                  25                  30          


Thr Ser Val Asn Glu Arg Ile Glu Asn Lys Arg Arg Thr Ala Leu Leu 
        35                  40                  45              


Gly Gly Gly Gln Arg Arg Ile Asp Ala Gln His Lys Arg Gly Lys Leu 
    50                  55                  60                  


Thr Ala Arg Glu Arg Ile Ser Leu Leu Leu Asp Pro Gly Ser Phe Val 
65                  70                  75                  80  


Glu Ser Asp Met Phe Val Glu His Arg Cys Ala Asp Phe Gly Met Ala 
                85                  90                  95      


Ala Asp Lys Asn Lys Phe Pro Gly Asp Ser Val Val Thr Gly Arg Gly 
            100                 105                 110         


Arg Ile Asn Gly Arg Leu Val Tyr Val Phe Ser Gln Ile Arg Ala Ser 
        115                 120                 125             


Ala Met Ser Pro Arg Leu Val Ser Asp Ser Trp Thr Gln Ala Ile His 
    130                 135                 140                 


Leu Pro Trp Pro Pro Lys Val Leu Gly Leu Gln Asp Phe Thr Val Phe 
145                 150                 155                 160 


Gly Gly Ser Leu Ser Gly Ala His Ala Gln Lys Ile Cys Lys Ile Met 
                165                 170                 175     


Asp Gln Ala Ile Thr Val Gly Ala Pro Val Ile Gly Leu Asn Asp Ser 
            180                 185                 190         


Gly Gly Ala Arg Ile Gln Glu Gly Val Glu Ser Leu Ala Gly Tyr Ala 
        195                 200                 205             


Asp Ile Phe Leu Arg Asn Val Thr Ala Ser Gly Val Ile Pro Gln Ile 
    210                 215                 220                 


Ser Leu Ile Met Gly Pro Cys Ala Gly Gly Ala Val Tyr Ser Pro Ala 
225                 230                 235                 240 


Leu Thr Asp Phe Thr Phe Met Val Lys Asp Thr Ser Tyr Leu Phe Ile 
                245                 250                 255     


Thr Gly Pro Asp Val Val Lys Ser Val Thr Asn Glu Asp Val Thr Gln 
            260                 265                 270         


Glu Glu Leu Gly Gly Ala Lys Thr His Thr Thr Met Ser Gly Val Ala 
        275                 280                 285             


His Arg Ala Phe Glu Asn Asp Val Asp Ala Leu Cys Asn Leu Arg Asp 
    290                 295                 300                 


Phe Phe Asn Tyr Leu Pro Leu Ser Ser Gln Asp Pro Ala Pro Val Arg 
305                 310                 315                 320 


Glu Cys His Asp Pro Ser Asp Arg Leu Val Pro Glu Leu Asp Thr Ile 
                325                 330                 335     


Val Pro Leu Glu Ser Thr Lys Ala Tyr Asn Met Val Asp Ile Ile His 
            340                 345                 350         


Ser Val Val Asp Glu Arg Glu Phe Phe Glu Ile Met Pro Asn Tyr Ala 
        355                 360                 365             


Lys Asn Ile Ile Val Gly Phe Ala Arg Met Asn Gly Arg Thr Val Gly 
    370                 375                 380                 


Ile Val Gly Asn Gln Pro Lys Val Ala Ser Gly Cys Leu Asp Ile Asn 
385                 390                 395                 400 


Ser Ser Val Lys Gly Ala Arg Phe Val Arg Phe Cys Asp Ala Phe Asn 
                405                 410                 415     


Ile Pro Leu Ile Thr Phe Val Asp Val Pro Gly Phe Leu Pro Gly Thr 
            420                 425                 430         


Ala Gln Glu Tyr Gly Gly Ile Ile Arg His Gly Ala Lys Leu Leu Tyr 
        435                 440                 445             


Ala Phe Ala Glu Ala Thr Val Pro Lys Val Thr Val Ile Thr Arg Lys 
    450                 455                 460                 


Ala Tyr Gly Gly Ala Tyr Asp Val Met Ser Ser Lys His Leu Cys Gly 
465                 470                 475                 480 


Asp Thr Asn Tyr Ala Trp Pro Thr Ala Glu Ile Ala Val Met Gly Ala 
                485                 490                 495     


Lys Gly Ala Val Glu Ile Ile Phe Lys Gly His Glu Asn Val Glu Ala 
            500                 505                 510         


Ala Gln Ala Glu Tyr Ile Glu Lys Phe Ala Asn Pro Phe Pro Ala Ala 
        515                 520                 525             


Val Arg Gly Phe Val Asp Asp Ile Ile Gln Pro Ser Ser Thr Arg Ala 
    530                 535                 540                 


Arg Ile Cys Cys Asp Leu Asp Val Leu Ala Ser Lys Lys Val Gln Arg 
545                 550                 555                 560 


Pro Trp Arg Lys His Ala Asn Ile Pro Leu 
                565                 570 


<210>  10040
<211>  559
<212>  PRT
<213>  Homo Sapiens

<400>  10040

Met Ala Ala Ala Leu Arg Val Ala Ala Val Gly Ala Arg Leu Ser Val 
1               5                   10                  15      


Leu Ala Ser Gly Leu Arg Ala Ala Val Arg Ser Leu Cys Ser Gln Ala 
            20                  25                  30          


Thr Ser Val Asn Glu Arg Ile Glu Asn Lys Arg Arg Thr Ala Leu Leu 
        35                  40                  45              


Gly Gly Gly Gln Arg Arg Ile Asp Ala Gln His Lys Arg Gly Lys Leu 
    50                  55                  60                  


Thr Ala Arg Glu Arg Ile Ser Leu Leu Leu Asp Pro Gly Ser Phe Val 
65                  70                  75                  80  


Glu Ser Asp Met Phe Val Glu His Arg Cys Ala Asp Phe Gly Met Ala 
                85                  90                  95      


Ala Asp Lys Asn Lys Phe Pro Gly Asp Ser Val Val Thr Gly Arg Gly 
            100                 105                 110         


Arg Ile Asn Gly Arg Leu Val Tyr Val Phe Ser Gln Gln Ile Ile Gly 
        115                 120                 125             


Trp Ala Gln Trp Leu Pro Leu Val Ile Ser Ala Leu Trp Glu Ala Glu 
    130                 135                 140                 


Asp Phe Thr Val Phe Gly Gly Ser Leu Ser Gly Ala His Ala Gln Lys 
145                 150                 155                 160 


Ile Cys Lys Ile Met Asp Gln Ala Ile Thr Val Gly Ala Pro Val Ile 
                165                 170                 175     


Gly Leu Asn Asp Ser Gly Gly Ala Arg Ile Gln Glu Gly Val Glu Ser 
            180                 185                 190         


Leu Ala Gly Tyr Ala Asp Ile Phe Leu Arg Asn Val Thr Ala Ser Gly 
        195                 200                 205             


Val Ile Pro Gln Ile Ser Leu Ile Met Gly Pro Cys Ala Gly Gly Ala 
    210                 215                 220                 


Val Tyr Ser Pro Ala Leu Thr Asp Phe Thr Phe Met Val Lys Asp Thr 
225                 230                 235                 240 


Ser Tyr Leu Phe Ile Thr Gly Pro Asp Val Val Lys Ser Val Thr Asn 
                245                 250                 255     


Glu Asp Val Thr Gln Glu Glu Leu Gly Gly Ala Lys Thr His Thr Thr 
            260                 265                 270         


Met Ser Gly Val Ala His Arg Ala Phe Glu Asn Asp Val Asp Ala Leu 
        275                 280                 285             


Cys Asn Leu Arg Asp Phe Phe Asn Tyr Leu Pro Leu Ser Ser Gln Asp 
    290                 295                 300                 


Pro Ala Pro Val Arg Glu Cys His Asp Pro Ser Asp Arg Leu Val Pro 
305                 310                 315                 320 


Glu Leu Asp Thr Ile Val Pro Leu Glu Ser Thr Lys Ala Tyr Asn Met 
                325                 330                 335     


Val Asp Ile Ile His Ser Val Val Asp Glu Arg Glu Phe Phe Glu Ile 
            340                 345                 350         


Met Pro Asn Tyr Ala Lys Asn Ile Ile Val Gly Phe Ala Arg Met Asn 
        355                 360                 365             


Gly Arg Thr Val Gly Ile Val Gly Asn Gln Pro Lys Val Ala Ser Gly 
    370                 375                 380                 


Cys Leu Asp Ile Asn Ser Ser Val Lys Gly Ala Arg Phe Val Arg Phe 
385                 390                 395                 400 


Cys Asp Ala Phe Asn Ile Pro Leu Ile Thr Phe Val Asp Val Pro Gly 
                405                 410                 415     


Phe Leu Pro Gly Thr Ala Gln Glu Tyr Gly Gly Ile Ile Arg His Gly 
            420                 425                 430         


Ala Lys Leu Leu Tyr Ala Phe Ala Glu Ala Thr Val Pro Lys Val Thr 
        435                 440                 445             


Val Ile Thr Arg Lys Ala Tyr Gly Gly Ala Tyr Asp Val Met Ser Ser 
    450                 455                 460                 


Lys His Leu Cys Gly Asp Thr Asn Tyr Ala Trp Pro Thr Ala Glu Ile 
465                 470                 475                 480 


Ala Val Met Gly Ala Lys Gly Ala Val Glu Ile Ile Phe Lys Gly His 
                485                 490                 495     


Glu Asn Val Glu Ala Ala Gln Ala Glu Tyr Ile Glu Lys Phe Ala Asn 
            500                 505                 510         


Pro Phe Pro Ala Ala Val Arg Gly Phe Val Asp Asp Ile Ile Gln Pro 
        515                 520                 525             


Ser Ser Thr Arg Ala Arg Ile Cys Cys Asp Leu Asp Val Leu Ala Ser 
    530                 535                 540                 


Lys Lys Val Gln Arg Pro Trp Arg Lys His Ala Asn Ile Pro Leu 
545                 550                 555                 


<210>  10041
<211>  482
<212>  PRT
<213>  Homo Sapiens

<400>  10041

Met Ala Ala Ala Leu Arg Val Ala Ala Val Gly Ala Arg Leu Ser Val 
1               5                   10                  15      


Leu Ala Ser Gly Leu Arg Ala Ala Val Arg Ser Leu Cys Ser Gln Ala 
            20                  25                  30          


Thr Ser Val Asn Glu Arg Ile Glu Asn Lys Arg Arg Thr Ala Leu Leu 
        35                  40                  45              


Gly Gly Gly Gln Arg Arg Ile Asp Ala Gln His Lys Arg Gly Lys Leu 
    50                  55                  60                  


Thr Ala Arg Glu Arg Ile Ser Leu Leu Leu Asp Pro Gly Ser Phe Val 
65                  70                  75                  80  


Glu Ser Asp Met Phe Val Glu His Arg Cys Ala Asp Phe Gly Met Ala 
                85                  90                  95      


Ala Asp Lys Asn Lys Phe Pro Gly Asp Ser Val Val Thr Gly Arg Gly 
            100                 105                 110         


Arg Ile Asn Gly Arg Leu Val Tyr Val Phe Ser Gln Arg Asn Val Thr 
        115                 120                 125             


Ala Ser Gly Val Ile Pro Gln Ile Ser Leu Ile Met Gly Pro Cys Ala 
    130                 135                 140                 


Gly Gly Ala Val Tyr Ser Pro Ala Leu Thr Asp Phe Thr Phe Met Val 
145                 150                 155                 160 


Lys Asp Thr Ser Tyr Leu Phe Ile Thr Gly Pro Asp Val Val Lys Ser 
                165                 170                 175     


Val Thr Asn Glu Asp Val Thr Gln Glu Glu Leu Gly Gly Ala Lys Thr 
            180                 185                 190         


His Thr Thr Met Ser Gly Val Ala His Arg Ala Phe Glu Asn Asp Val 
        195                 200                 205             


Asp Ala Leu Cys Asn Leu Arg Asp Phe Phe Asn Tyr Leu Pro Leu Ser 
    210                 215                 220                 


Ser Gln Asp Pro Ala Pro Val Arg Glu Cys His Asp Pro Ser Asp Arg 
225                 230                 235                 240 


Leu Val Pro Glu Leu Asp Thr Ile Val Pro Leu Glu Ser Thr Lys Ala 
                245                 250                 255     


Tyr Asn Met Val Asp Ile Ile His Ser Val Val Asp Glu Arg Glu Phe 
            260                 265                 270         


Phe Glu Ile Met Pro Asn Tyr Ala Lys Asn Ile Ile Val Gly Phe Ala 
        275                 280                 285             


Arg Met Asn Gly Arg Thr Val Gly Ile Val Gly Asn Gln Pro Lys Val 
    290                 295                 300                 


Ala Ser Gly Cys Leu Asp Ile Asn Ser Ser Val Lys Gly Ala Arg Phe 
305                 310                 315                 320 


Val Arg Phe Cys Asp Ala Phe Asn Ile Pro Leu Ile Thr Phe Val Asp 
                325                 330                 335     


Val Pro Gly Phe Leu Pro Gly Thr Ala Gln Glu Tyr Gly Gly Ile Ile 
            340                 345                 350         


Arg His Gly Ala Lys Leu Leu Tyr Ala Phe Ala Glu Ala Thr Val Pro 
        355                 360                 365             


Lys Val Thr Val Ile Thr Arg Lys Ala Tyr Gly Gly Ala Tyr Asp Val 
    370                 375                 380                 


Met Ser Ser Lys His Leu Cys Gly Asp Thr Asn Tyr Ala Trp Pro Thr 
385                 390                 395                 400 


Ala Glu Ile Ala Val Met Gly Ala Lys Gly Ala Val Glu Ile Ile Phe 
                405                 410                 415     


Lys Gly His Glu Asn Val Glu Ala Ala Gln Ala Glu Tyr Ile Glu Lys 
            420                 425                 430         


Phe Ala Asn Pro Phe Pro Ala Ala Val Arg Gly Phe Val Asp Asp Ile 
        435                 440                 445             


Ile Gln Pro Ser Ser Thr Arg Ala Arg Ile Cys Cys Asp Leu Asp Val 
    450                 455                 460                 


Leu Ala Ser Lys Lys Val Gln Arg Pro Trp Arg Lys His Ala Asn Ile 
465                 470                 475                 480 


Pro Leu 
        


<210>  10042
<211>  84
<212>  PRT
<213>  Homo Sapiens

<400>  10042

Met Phe Val Glu His Arg Cys Ala Asp Phe Gly Met Ala Ala Asp Lys 
1               5                   10                  15      


Asn Lys Phe Pro Gly Asp Ser Val Val Thr Gly Arg Gly Arg Ile Asn 
            20                  25                  30          


Gly Arg Leu Val Tyr Val Phe Ser Gln Asp Phe Thr Val Phe Gly Gly 
        35                  40                  45              


Ser Leu Ser Gly Ala His Ala Gln Lys Ile Cys Lys Ile Met Asp Gln 
    50                  55                  60                  


Ala Ile Thr Val Gly Ala Pro Val Ile Gly Leu Asn Asp Ser Gly Gly 
65                  70                  75                  80  


Ala Arg Ile Gln 
                


<210>  10043
<211>  134
<212>  PRT
<213>  Homo Sapiens

<400>  10043

Met Phe Val Glu His Arg Cys Ala Asp Phe Gly Met Ala Ala Asp Lys 
1               5                   10                  15      


Asn Lys Phe Pro Gly Asp Ser Val Val Thr Gly Arg Gly Arg Ile Asn 
            20                  25                  30          


Gly Arg Leu Val Tyr Val Phe Ser Gln Asp Phe Thr Val Phe Gly Gly 
        35                  40                  45              


Ser Leu Ser Gly Ala His Ala Gln Lys Ile Cys Lys Ile Met Asp Gln 
    50                  55                  60                  


Ala Ile Thr Val Gly Ala Pro Val Ile Gly Leu Asn Asp Ser Gly Gly 
65                  70                  75                  80  


Ala Arg Ile Gln Glu Gly Val Glu Ser Leu Ala Gly Tyr Ala Asp Ile 
                85                  90                  95      


Phe Leu Arg Asn Val Thr Ala Ser Gly Val Ile Pro Gln Ile Ser Leu 
            100                 105                 110         


Ile Met Gly Pro Cys Ala Gly Gly Ala Val Tyr Ser Pro Ala Leu Thr 
        115                 120                 125             


Asp Phe Thr Phe Met Val 
    130                 


<210>  10044
<211>  163
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  10044

Xaa Glu Ser Ser Trp Pro Ser Glu Ile Ser Trp Ala Ala His Phe Gly 
1               5                   10                  15      


Glu Gly Lys Leu Thr Ala Arg Glu Arg Ile Ser Leu Leu Leu Asp Pro 
            20                  25                  30          


Gly Ser Phe Val Glu Ser Asp Met Phe Val Glu His Arg Cys Ala Asp 
        35                  40                  45              


Phe Gly Met Ala Ala Asp Lys Asn Lys Phe Pro Gly Asp Ser Val Val 
    50                  55                  60                  


Thr Gly Arg Gly Arg Ile Asn Gly Arg Leu Val Tyr Val Phe Ser Gln 
65                  70                  75                  80  


Asp Phe Thr Val Phe Gly Gly Ser Leu Ser Gly Ala His Ala Gln Lys 
                85                  90                  95      


Ile Cys Lys Ile Met Asp Gln Ala Ile Thr Val Gly Ala Pro Val Ile 
            100                 105                 110         


Gly Leu Asn Asp Ser Gly Gly Ala Arg Ile Gln Glu Gly Val Glu Ser 
        115                 120                 125             


Leu Ala Gly Tyr Ala Asp Ile Phe Leu Arg Asn Val Thr Ala Ser Gly 
    130                 135                 140                 


Val Ile Pro Gln Ile Ser Leu Ile Met Gly Pro Cys Ala Gly Gly Ala 
145                 150                 155                 160 


Val Tyr Ser 
            


<210>  10045
<211>  1237
<212>  PRT
<213>  Homo Sapiens

<400>  10045

Met Asp Ser Gly Ala Gly Gly Arg Arg Cys Pro Glu Ala Ala Leu Leu 
1               5                   10                  15      


Ile Leu Gly Pro Pro Arg Met Glu His Leu Arg His Ser Pro Gly Pro 
            20                  25                  30          


Gly Gly Gln Arg Leu Leu Leu Pro Ser Met Leu Leu Ala Leu Leu Leu 
        35                  40                  45              


Leu Leu Ala Pro Ser Pro Gly His Ala Thr Arg Val Val Tyr Lys Val 
    50                  55                  60                  


Pro Glu Glu Gln Pro Pro Asn Thr Leu Ile Gly Ser Leu Ala Ala Asp 
65                  70                  75                  80  


Tyr Gly Phe Pro Asp Val Gly His Leu Tyr Lys Leu Glu Val Gly Ala 
                85                  90                  95      


Pro Tyr Leu Arg Val Asp Gly Lys Thr Gly Asp Ile Phe Thr Thr Glu 
            100                 105                 110         


Thr Ser Ile Asp Arg Glu Gly Leu Arg Glu Cys Gln Asn Gln Leu Pro 
        115                 120                 125             


Gly Asp Pro Cys Ile Leu Glu Phe Glu Val Ser Ile Thr Asp Leu Val 
    130                 135                 140                 


Gln Asn Gly Ser Pro Arg Leu Leu Glu Gly Gln Ile Glu Val Gln Asp 
145                 150                 155                 160 


Ile Asn Asp Asn Thr Pro Asn Phe Ala Ser Pro Val Ile Thr Leu Ala 
                165                 170                 175     


Ile Pro Glu Asn Thr Asn Ile Gly Ser Leu Phe Pro Ile Pro Leu Ala 
            180                 185                 190         


Ser Asp Arg Asp Ala Gly Pro Asn Gly Val Ala Ser Tyr Glu Leu Gln 
        195                 200                 205             


Ala Gly Pro Glu Ala Gln Glu Leu Phe Gly Leu Gln Val Ala Glu Asp 
    210                 215                 220                 


Gln Glu Glu Lys Gln Pro Gln Leu Ile Val Met Gly Asn Leu Asp Arg 
225                 230                 235                 240 


Glu Arg Trp Asp Ser Tyr Asp Leu Thr Ile Lys Val Gln Asp Gly Gly 
                245                 250                 255     


Ser Pro Pro Arg Ala Ser Ser Ala Leu Leu Arg Val Thr Val Leu Asp 
            260                 265                 270         


Thr Asn Asp Asn Ala Pro Lys Phe Glu Arg Pro Ser Tyr Glu Ala Glu 
        275                 280                 285             


Leu Ser Glu Asn Ser Pro Ile Gly His Ser Val Ile Gln Val Lys Ala 
    290                 295                 300                 


Asn Asp Ser Asp Gln Gly Ala Asn Ala Glu Ile Glu Tyr Thr Phe His 
305                 310                 315                 320 


Gln Ala Pro Glu Val Val Arg Arg Leu Leu Arg Leu Asp Arg Asn Thr 
                325                 330                 335     


Gly Leu Ile Thr Val Gln Gly Pro Val Asp Arg Glu Asp Leu Ser Thr 
            340                 345                 350         


Leu Arg Phe Ser Val Leu Ala Lys Asp Arg Gly Thr Asn Pro Lys Ser 
        355                 360                 365             


Ala Arg Ala Gln Val Val Val Thr Val Lys Asp Met Asn Asp Asn Ala 
    370                 375                 380                 


Pro Thr Ile Glu Ile Arg Gly Ile Gly Leu Val Thr His Gln Asp Gly 
385                 390                 395                 400 


Met Ala Asn Ile Ser Glu Asp Val Ala Glu Glu Thr Ala Val Ala Leu 
                405                 410                 415     


Val Gln Val Ser Asp Arg Asp Glu Gly Glu Asn Ala Ala Val Thr Cys 
            420                 425                 430         


Val Val Ala Gly Asp Val Pro Phe Gln Leu Arg Gln Ala Ser Glu Thr 
        435                 440                 445             


Gly Ser Asp Ser Lys Lys Lys Tyr Phe Leu Gln Thr Thr Thr Pro Leu 
    450                 455                 460                 


Asp Tyr Glu Lys Val Lys Asp Tyr Thr Ile Glu Ile Val Ala Val Asp 
465                 470                 475                 480 


Ser Gly Asn Pro Pro Leu Ser Ser Thr Asn Ser Leu Lys Val Gln Val 
                485                 490                 495     


Val Asp Val Asn Asp Asn Ala Pro Val Phe Thr Gln Ser Val Thr Glu 
            500                 505                 510         


Val Ala Phe Pro Glu Asn Asn Lys Pro Gly Glu Val Ile Ala Glu Ile 
        515                 520                 525             


Thr Ala Ser Asp Ala Asp Ser Gly Ser Asn Ala Glu Leu Val Tyr Ser 
    530                 535                 540                 


Leu Glu Pro Glu Pro Ala Ala Lys Gly Leu Phe Thr Ile Ser Pro Glu 
545                 550                 555                 560 


Thr Gly Glu Ile Gln Val Lys Thr Ser Leu Asp Arg Glu Gln Arg Glu 
                565                 570                 575     


Ser Tyr Glu Leu Lys Val Val Ala Ala Asp Arg Gly Ser Pro Ser Leu 
            580                 585                 590         


Gln Gly Thr Ala Thr Val Leu Val Asn Val Leu Asp Cys Asn Asp Asn 
        595                 600                 605             


Asp Pro Lys Phe Met Leu Ser Gly Tyr Asn Phe Ser Val Met Glu Asn 
    610                 615                 620                 


Met Pro Ala Leu Ser Pro Val Gly Met Val Thr Val Ile Asp Gly Asp 
625                 630                 635                 640 


Lys Gly Glu Asn Ala Gln Val Gln Leu Ser Val Glu Gln Asp Asn Gly 
                645                 650                 655     


Asp Phe Val Ile Gln Asn Gly Thr Gly Thr Ile Leu Ser Ser Leu Ser 
            660                 665                 670         


Phe Asp Arg Glu Gln Gln Ser Thr Tyr Thr Phe Gln Leu Lys Ala Val 
        675                 680                 685             


Asp Gly Gly Val Pro Pro Arg Ser Ala Tyr Val Gly Val Thr Ile Asn 
    690                 695                 700                 


Val Leu Asp Glu Asn Asp Asn Ala Pro Tyr Ile Thr Ala Pro Ser Asn 
705                 710                 715                 720 


Thr Ser His Lys Leu Leu Thr Pro Gln Thr Arg Leu Gly Glu Thr Val 
                725                 730                 735     


Ser Gln Val Ala Ala Glu Asp Phe Asp Ser Gly Val Asn Ala Glu Leu 
            740                 745                 750         


Ile Tyr Ser Ile Ala Gly Gly Asn Pro Tyr Gly Leu Phe Gln Ile Gly 
        755                 760                 765             


Ser His Ser Gly Ala Ile Thr Leu Glu Lys Glu Ile Glu Arg Arg His 
    770                 775                 780                 


His Gly Leu His Arg Leu Val Val Lys Val Ser Asp Arg Gly Lys Pro 
785                 790                 795                 800 


Pro Arg Tyr Gly Thr Ala Leu Val His Leu Tyr Val Asn Glu Thr Leu 
                805                 810                 815     


Ala Asn Arg Thr Leu Leu Glu Thr Leu Leu Gly His Ser Leu Asp Thr 
            820                 825                 830         


Pro Leu Asp Ile Asp Ile Ala Gly Asp Pro Glu Tyr Glu Arg Ser Lys 
        835                 840                 845             


Gln Arg Gly Asn Ile Leu Phe Gly Val Val Ala Gly Val Val Ala Val 
    850                 855                 860                 


Ala Leu Leu Ile Ala Leu Ala Val Leu Val Arg Tyr Cys Arg Gln Arg 
865                 870                 875                 880 


Glu Ala Lys Ser Gly Tyr Gln Ala Gly Lys Lys Glu Thr Lys Asp Leu 
                885                 890                 895     


Tyr Ala Pro Lys Pro Ser Gly Lys Ala Ser Lys Gly Asn Lys Ser Lys 
            900                 905                 910         


Gly Lys Lys Ser Lys Ser Pro Lys Pro Val Lys Pro Val Glu Asp Glu 
        915                 920                 925             


Asp Glu Ala Gly Leu Gln Lys Ser Leu Lys Phe Asn Leu Met Ser Asp 
    930                 935                 940                 


Ala Pro Gly Asp Ser Pro Arg Ile His Leu Pro Leu Asn Tyr Pro Pro 
945                 950                 955                 960 


Gly Ser Pro Asp Leu Gly Arg His Tyr Arg Ser Asn Ser Pro Leu Pro 
                965                 970                 975     


Ser Ile Gln Leu Gln Pro Gln Ser Pro Ser Ala Ser Lys Lys His Gln 
            980                 985                 990         


Val Val Gln Asp Leu Pro Pro Ala  Asn Thr Phe Val Gly  Thr Gly Asp 
        995                 1000                 1005             


Thr Thr  Ser Thr Gly Ser Glu  Gln Tyr Ser Asp Tyr  Ser Tyr Arg 
    1010                 1015                 1020             


Thr Asn  Pro Pro Lys Tyr Pro  Ser Lys Gln Leu Pro  His Arg Arg 
    1025                 1030                 1035             


Val Thr  Phe Ser Ala Thr Ser  Gln Ala Gln Glu Leu  Gln Asp Pro 
    1040                 1045                 1050             


Ser Gln  His Ser Tyr Tyr Asp  Ser Gly Leu Glu Glu  Ser Glu Thr 
    1055                 1060                 1065             


Pro Ser  Ser Lys Ser Ser Ser  Gly Pro Arg Leu Gly  Pro Leu Ala 
    1070                 1075                 1080             


Leu Pro  Glu Asp His Tyr Glu  Arg Thr Thr Pro Asp  Gly Ser Ile 
    1085                 1090                 1095             


Gly Glu  Met Glu His Pro Glu  Asn Asp Leu Arg Pro  Leu Pro Asp 
    1100                 1105                 1110             


Val Ala  Met Thr Gly Thr Cys  Thr Arg Glu Cys Ser  Glu Phe Gly 
    1115                 1120                 1125             


His Ser  Asp Thr Cys Trp Met  Pro Gly Gln Ser Ser  Pro Ser Arg 
    1130                 1135                 1140             


Arg Thr  Lys Ser Ser Ala Leu  Lys Leu Ser Thr Phe  Val Pro Tyr 
    1145                 1150                 1155             


Gln Asp  Arg Gly Gly Gln Glu  Pro Ala Gly Ala Gly  Ser Pro Ser 
    1160                 1165                 1170             


Pro Pro  Glu Asp Arg Asn Thr  Lys Thr Ala Pro Val  Arg Leu Leu 
    1175                 1180                 1185             


Pro Ser  Tyr Ser Ala Phe Ser  His Ser Ser His Asp  Ser Cys Lys 
    1190                 1195                 1200             


Asp Ser  Ala Thr Leu Glu Glu  Ile Pro Leu Thr Gln  Thr Ser Asp 
    1205                 1210                 1215             


Phe Pro  Pro Ala Ala Thr Pro  Ala Ser Ala Gln Thr  Ala Lys Arg 
    1220                 1225                 1230             


Glu Ile  Tyr Leu 
    1235         


<210>  10046
<211>  1060
<212>  PRT
<213>  Homo Sapiens

<400>  10046

Met Asp Ser Gly Ala Gly Gly Arg Arg Cys Pro Glu Ala Ala Leu Leu 
1               5                   10                  15      


Ile Leu Gly Pro Pro Arg Met Glu His Leu Arg His Ser Pro Gly Pro 
            20                  25                  30          


Gly Gly Gln Arg Leu Leu Leu Pro Ser Met Leu Leu Ala Leu Leu Leu 
        35                  40                  45              


Leu Leu Ala Pro Ser Pro Gly His Ala Thr Arg Val Val Tyr Lys Val 
    50                  55                  60                  


Pro Glu Glu Gln Pro Pro Asn Thr Leu Ile Gly Ser Leu Ala Ala Asp 
65                  70                  75                  80  


Tyr Gly Phe Pro Asp Val Gly His Leu Tyr Lys Leu Glu Val Gly Ala 
                85                  90                  95      


Pro Tyr Leu Arg Val Asp Gly Lys Thr Gly Asp Ile Phe Thr Thr Glu 
            100                 105                 110         


Thr Ser Ile Asp Arg Glu Gly Leu Arg Glu Cys Gln Asn Gln Leu Pro 
        115                 120                 125             


Gly Asp Pro Cys Ile Leu Glu Phe Glu Val Ser Ile Thr Asp Leu Val 
    130                 135                 140                 


Gln Asn Gly Ser Pro Arg Leu Leu Glu Gly Gln Ile Glu Val Gln Asp 
145                 150                 155                 160 


Ile Asn Asp Asn Thr Pro Asn Phe Ala Ser Pro Val Ile Thr Leu Ala 
                165                 170                 175     


Ile Pro Glu Asn Thr Asn Ile Gly Ser Leu Phe Pro Ile Pro Leu Ala 
            180                 185                 190         


Ser Asp Arg Asp Ala Gly Pro Asn Gly Val Ala Ser Tyr Glu Leu Gln 
        195                 200                 205             


Ala Gly Pro Glu Ala Gln Glu Leu Phe Gly Leu Gln Val Ala Glu Asp 
    210                 215                 220                 


Gln Glu Glu Lys Gln Pro Gln Leu Ile Val Met Gly Asn Leu Asp Arg 
225                 230                 235                 240 


Glu Arg Trp Asp Ser Tyr Asp Leu Thr Ile Lys Val Gln Asp Gly Gly 
                245                 250                 255     


Ser Pro Pro Arg Ala Ser Ser Ala Leu Leu Arg Val Thr Val Leu Asp 
            260                 265                 270         


Thr Asn Asp Asn Ala Pro Lys Phe Glu Arg Pro Ser Tyr Glu Ala Glu 
        275                 280                 285             


Leu Ser Glu Asn Ser Pro Ile Gly His Ser Val Ile Gln Val Lys Ala 
    290                 295                 300                 


Asn Asp Ser Asp Gln Gly Ala Asn Ala Glu Ile Glu Tyr Thr Phe His 
305                 310                 315                 320 


Gln Ala Pro Glu Val Val Arg Arg Leu Leu Arg Leu Asp Arg Asn Thr 
                325                 330                 335     


Gly Leu Ile Thr Val Gln Gly Pro Val Asp Arg Glu Asp Leu Ser Thr 
            340                 345                 350         


Leu Arg Phe Ser Val Leu Ala Lys Asp Arg Gly Thr Asn Pro Lys Ser 
        355                 360                 365             


Ala Arg Ala Gln Val Val Val Thr Val Lys Asp Met Asn Asp Asn Ala 
    370                 375                 380                 


Pro Thr Ile Glu Ile Arg Gly Ile Gly Leu Val Thr His Gln Asp Gly 
385                 390                 395                 400 


Met Ala Asn Ile Ser Glu Asp Val Ala Glu Glu Thr Ala Val Ala Leu 
                405                 410                 415     


Val Gln Val Ser Asp Arg Asp Glu Gly Glu Asn Ala Ala Val Thr Cys 
            420                 425                 430         


Val Val Ala Gly Asp Val Pro Phe Gln Leu Arg Gln Ala Ser Glu Thr 
        435                 440                 445             


Gly Ser Asp Ser Lys Lys Lys Tyr Phe Leu Gln Thr Thr Thr Pro Leu 
    450                 455                 460                 


Asp Tyr Glu Lys Val Lys Asp Tyr Thr Ile Glu Ile Val Ala Val Asp 
465                 470                 475                 480 


Ser Gly Asn Pro Pro Leu Ser Ser Thr Asn Ser Leu Lys Val Gln Val 
                485                 490                 495     


Val Asp Val Asn Asp Asn Ala Pro Val Phe Thr Gln Ser Val Thr Glu 
            500                 505                 510         


Val Ala Phe Pro Glu Asn Asn Lys Pro Gly Glu Val Ile Ala Glu Ile 
        515                 520                 525             


Thr Ala Ser Asp Ala Asp Ser Gly Ser Asn Ala Glu Leu Val Tyr Ser 
    530                 535                 540                 


Leu Glu Pro Glu Pro Ala Ala Lys Gly Leu Phe Thr Ile Ser Pro Glu 
545                 550                 555                 560 


Thr Gly Glu Ile Gln Val Lys Thr Ser Leu Asp Arg Glu Gln Arg Glu 
                565                 570                 575     


Ser Tyr Glu Leu Lys Val Val Ala Ala Asp Arg Gly Ser Pro Ser Leu 
            580                 585                 590         


Gln Gly Thr Ala Thr Val Leu Val Asn Val Leu Asp Cys Asn Asp Asn 
        595                 600                 605             


Asp Pro Lys Phe Met Leu Ser Gly Tyr Asn Phe Ser Val Met Glu Asn 
    610                 615                 620                 


Met Pro Ala Leu Ser Pro Val Gly Met Val Thr Val Ile Asp Gly Asp 
625                 630                 635                 640 


Lys Gly Glu Asn Ala Gln Val Gln Leu Ser Val Glu Gln Asp Asn Gly 
                645                 650                 655     


Asp Phe Val Ile Gln Asn Gly Thr Gly Thr Ile Leu Ser Ser Leu Ser 
            660                 665                 670         


Phe Asp Arg Glu Gln Gln Ser Thr Tyr Thr Phe Gln Leu Lys Ala Val 
        675                 680                 685             


Asp Gly Gly Val Pro Pro Arg Ser Ala Tyr Val Gly Val Thr Ile Asn 
    690                 695                 700                 


Val Leu Asp Glu Asn Asp Asn Ala Pro Tyr Ile Thr Ala Pro Ser Asn 
705                 710                 715                 720 


Thr Ser His Lys Leu Leu Thr Pro Gln Thr Arg Leu Gly Glu Thr Val 
                725                 730                 735     


Ser Gln Val Ala Ala Glu Asp Phe Asp Ser Gly Val Asn Ala Glu Leu 
            740                 745                 750         


Ile Tyr Ser Ile Ala Gly Gly Asn Pro Tyr Gly Leu Phe Gln Ile Gly 
        755                 760                 765             


Ser His Ser Gly Ala Ile Thr Leu Glu Lys Glu Ile Glu Arg Arg His 
    770                 775                 780                 


His Gly Leu His Arg Leu Val Val Lys Val Ser Asp Arg Gly Lys Pro 
785                 790                 795                 800 


Pro Arg Tyr Gly Thr Ala Leu Val His Leu Tyr Val Asn Glu Thr Leu 
                805                 810                 815     


Ala Asn Arg Thr Leu Leu Glu Thr Leu Leu Gly His Ser Leu Asp Thr 
            820                 825                 830         


Pro Leu Asp Ile Asp Ile Ala Gly Asp Pro Glu Tyr Glu Arg Ser Lys 
        835                 840                 845             


Gln Arg Gly Asn Ile Leu Phe Gly Val Val Ala Gly Val Val Ala Val 
    850                 855                 860                 


Ala Leu Leu Ile Ala Leu Ala Val Leu Val Arg Tyr Cys Arg Gln Arg 
865                 870                 875                 880 


Glu Ala Lys Ser Gly Tyr Gln Ala Gly Lys Lys Glu Thr Lys Asp Leu 
                885                 890                 895     


Tyr Ala Pro Lys Pro Ser Gly Lys Ala Ser Lys Gly Asn Lys Ser Lys 
            900                 905                 910         


Gly Lys Lys Ser Lys Ser Pro Lys Pro Val Lys Pro Val Glu Asp Glu 
        915                 920                 925             


Asp Glu Ala Gly Leu Gln Lys Ser Leu Lys Phe Asn Leu Met Ser Asp 
    930                 935                 940                 


Ala Pro Gly Asp Ser Pro Arg Ile His Leu Pro Leu Asn Tyr Pro Pro 
945                 950                 955                 960 


Gly Ser Pro Asp Leu Gly Arg His Tyr Arg Ser Asn Ser Pro Leu Pro 
                965                 970                 975     


Ser Ile Gln Leu Gln Pro Gln Ser Pro Ser Ala Ser Lys Lys His Gln 
            980                 985                 990         


Val Val Gln Asp Leu Pro Pro Ala  Asn Thr Phe Val Gly  Thr Gly Asp 
        995                 1000                 1005             


Thr Thr  Ser Thr Gly Ser Glu  Gln Tyr Ser Asp Tyr  Ser Tyr Arg 
    1010                 1015                 1020             


Thr Asn  Pro Pro Lys Tyr Pro  Ser Lys Gln Val Gly  Gln Pro Phe 
    1025                 1030                 1035             


Gln Leu  Ser Thr Pro Gln Pro  Leu Pro His Pro Tyr  His Gly Ala 
    1040                 1045                 1050             


Ile Trp  Thr Glu Val Trp Glu  
    1055                 1060 


<210>  10047
<211>  382
<212>  PRT
<213>  Homo Sapiens

<400>  10047

Met Asp Ser Gly Ala Gly Gly Arg Arg Cys Pro Glu Ala Ala Leu Leu 
1               5                   10                  15      


Ile Leu Gly Pro Pro Arg Met Glu His Leu Arg His Ser Pro Gly Pro 
            20                  25                  30          


Gly Gly Gln Arg Leu Leu Leu Pro Ser Met Leu Leu Ala Leu Leu Leu 
        35                  40                  45              


Leu Leu Ala Pro Ser Pro Gly His Ala Thr Arg Val Val Tyr Lys Val 
    50                  55                  60                  


Pro Glu Glu Gln Pro Pro Asn Thr Leu Ile Gly Ser Leu Ala Ala Asp 
65                  70                  75                  80  


Tyr Gly Phe Pro Asp Val Gly His Leu Tyr Lys Leu Glu Val Gly Ala 
                85                  90                  95      


Pro Tyr Leu Arg Val Asp Gly Lys Thr Gly Asp Ile Phe Thr Thr Glu 
            100                 105                 110         


Thr Ser Ile Asp Arg Glu Gly Leu Arg Glu Cys Gln Asn Gln Leu Pro 
        115                 120                 125             


Gly Asp Pro Cys Ile Leu Glu Phe Glu Val Ser Ile Thr Asp Leu Val 
    130                 135                 140                 


Gln Asn Gly Ser Pro Arg Leu Leu Glu Gly Gln Ile Glu Val Gln Asp 
145                 150                 155                 160 


Ile Asn Asp Asn Thr Pro Asn Phe Ala Ser Pro Val Ile Thr Leu Ala 
                165                 170                 175     


Ile Pro Glu Asn Thr Asn Ile Gly Ser Leu Phe Pro Ile Pro Leu Ala 
            180                 185                 190         


Ser Asp Arg Asp Ala Gly Pro Asn Gly Val Ala Ser Tyr Glu Leu Gln 
        195                 200                 205             


Ala Gly Pro Glu Ala Gln Glu Leu Phe Gly Leu Gln Val Ala Glu Asp 
    210                 215                 220                 


Gln Glu Glu Lys Gln Pro Gln Leu Ile Val Met Gly Asn Leu Asp Arg 
225                 230                 235                 240 


Glu Arg Trp Asp Ser Tyr Asp Leu Thr Ile Lys Val Gln Asp Gly Gly 
                245                 250                 255     


Ser Pro Pro Arg Ala Ser Ser Ala Leu Leu Arg Val Thr Val Leu Asp 
            260                 265                 270         


Thr Asn Asp Asn Ala Pro Lys Phe Glu Arg Pro Ser Tyr Glu Ala Glu 
        275                 280                 285             


Leu Ser Glu Asn Ser Pro Ile Gly His Ser Val Ile Gln Leu Pro His 
    290                 295                 300                 


Arg Arg Val Thr Phe Ser Ala Thr Ser Gln Ala Gln Glu Leu Gln Asp 
305                 310                 315                 320 


Pro Ser Gln His Ser Tyr Tyr Asp Ser Gly Leu Glu Glu Ser Glu Thr 
                325                 330                 335     


Pro Ser Ser Lys Ser Ser Ser Gly Pro Arg Leu Gly Pro Leu Ala Leu 
            340                 345                 350         


Pro Glu Asp His Tyr Glu Arg Thr Thr Pro Asp Gly Ser Ile Gly Glu 
        355                 360                 365             


Met Glu His Pro Glu Asn Glu Pro Ala Gly Arg Ser Arg Pro 
    370                 375                 380         


<210>  10048
<211>  150
<212>  PRT
<213>  Homo Sapiens

<400>  10048

Met Glu His Leu Arg His Ser Pro Gly Pro Gly Gly Gln Arg Leu Leu 
1               5                   10                  15      


Leu Pro Ser Met Leu Leu Ala Leu Leu Leu Leu Leu Ala Pro Ser Pro 
            20                  25                  30          


Gly His Ala Thr Arg Val Val Tyr Lys Val Pro Glu Glu Gln Pro Pro 
        35                  40                  45              


Asn Thr Leu Ile Gly Ser Leu Ala Ala Asp Tyr Gly Phe Pro Asp Val 
    50                  55                  60                  


Gly His Leu Tyr Lys Leu Glu Val Gly Ala Pro Tyr Leu Arg Val Asp 
65                  70                  75                  80  


Gly Lys Thr Gly Asp Ile Phe Thr Thr Glu Thr Ser Ile Asp Arg Glu 
                85                  90                  95      


Gly Leu Arg Glu Cys Gln Asn Gln Leu Pro Gly Asp Pro Cys Ile Leu 
            100                 105                 110         


Glu Phe Glu Val Ser Ile Thr Asp Leu Val Gln Asn Gly Ser Pro Arg 
        115                 120                 125             


Leu Leu Glu Gly Gln Ile Glu Val Gln Asp Ile Asn Asp Asn Thr Pro 
    130                 135                 140                 


Asn Phe Ala Ser Pro Val 
145                 150 


<210>  10049
<211>  126
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  10049

Xaa Gly Pro Asn Gly Val Ala Ser Tyr Glu Leu Gln Ala Gly Pro Glu 
1               5                   10                  15      


Ala Gln Glu Leu Phe Gly Leu Gln Val Ala Glu Asp Gln Glu Glu Lys 
            20                  25                  30          


Gln Pro Gln Leu Ile Val Met Gly Asn Leu Asp Arg Glu Arg Trp Asp 
        35                  40                  45              


Ser Tyr Asp Leu Thr Ile Lys Val Gln Asp Gly Gly Ser Pro Pro Arg 
    50                  55                  60                  


Ala Ser Ser Ala Leu Leu Arg Val Thr Val Leu Asp Thr Asn Asp Asn 
65                  70                  75                  80  


Ala Pro Lys Phe Glu Arg Pro Ser Tyr Glu Ala Glu Leu Ser Glu Asn 
                85                  90                  95      


Ser Pro Ile Gly His Ser Val Ile Gln Ser Leu Val Asp Trp Asp Leu 
            100                 105                 110         


Glu Lys Arg Leu Arg Lys Lys Arg Glu Thr Asp Ser Arg Gly 
        115                 120                 125     


<210>  10050
<211>  17
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  10050

Xaa Ile Gln Val Arg Gly Pro Leu Arg Ile Thr Val Arg Val Thr His 
1               5                   10                  15      


His 
    


<210>  10051
<211>  23
<212>  PRT
<213>  Homo Sapiens

<400>  10051

Met Met Gln Leu Leu Gln Leu Leu Leu Gly Leu Leu Gly Pro Gly Gly 
1               5                   10                  15      


Tyr Leu Phe Leu Leu Gly Asp 
            20              


<210>  10052
<211>  1184
<212>  PRT
<213>  Homo Sapiens

<400>  10052

Met Met Gln Leu Leu Gln Leu Leu Leu Gly Leu Leu Gly Pro Gly Gly 
1               5                   10                  15      


Tyr Leu Phe Leu Leu Gly Asp Cys Gln Glu Val Thr Thr Leu Thr Val 
            20                  25                  30          


Lys Tyr Gln Val Ser Glu Glu Val Pro Ser Gly Thr Val Ile Gly Lys 
        35                  40                  45              


Leu Ser Gln Glu Leu Gly Arg Glu Glu Arg Arg Arg Gln Ala Gly Ala 
    50                  55                  60                  


Ala Phe Gln Val Leu Gln Leu Pro Gln Ala Leu Pro Ile Gln Val Asp 
65                  70                  75                  80  


Ser Glu Glu Gly Leu Leu Ser Thr Gly Arg Arg Leu Asp Arg Glu Gln 
                85                  90                  95      


Leu Cys Arg Gln Trp Asp Pro Cys Leu Val Ser Phe Asp Val Leu Ala 
            100                 105                 110         


Thr Gly Asp Leu Ala Leu Ile His Val Glu Ile Gln Val Leu Asp Ile 
        115                 120                 125             


Asn Asp His Gln Pro Arg Phe Pro Lys Gly Glu Gln Glu Leu Glu Ile 
    130                 135                 140                 


Ser Glu Ser Ala Ser Leu Arg Thr Arg Ile Pro Leu Asp Arg Ala Leu 
145                 150                 155                 160 


Asp Pro Asp Thr Gly Pro Asn Thr Leu His Thr Tyr Thr Leu Ser Pro 
                165                 170                 175     


Ser Glu His Phe Ala Leu Asp Val Ile Val Gly Pro Asp Glu Thr Lys 
            180                 185                 190         


His Ala Glu Leu Ile Val Val Lys Glu Leu Asp Arg Glu Ile His Ser 
        195                 200                 205             


Phe Phe Asp Leu Val Leu Thr Ala Tyr Asp Asn Gly Asn Pro Pro Lys 
    210                 215                 220                 


Ser Gly Thr Ser Leu Val Lys Val Asn Val Leu Asp Ser Asn Asp Asn 
225                 230                 235                 240 


Ser Pro Ala Phe Ala Glu Ser Ser Leu Ala Leu Glu Ile Gln Glu Asp 
                245                 250                 255     


Ala Ala Pro Gly Thr Leu Leu Ile Lys Leu Thr Ala Thr Asp Pro Asp 
            260                 265                 270         


Gln Gly Pro Asn Gly Glu Val Glu Phe Phe Leu Ser Lys His Met Pro 
        275                 280                 285             


Pro Glu Val Leu Asp Thr Phe Ser Ile Asp Ala Lys Thr Gly Gln Val 
    290                 295                 300                 


Ile Leu Arg Arg Pro Leu Asp Tyr Glu Lys Asn Pro Ala Tyr Glu Val 
305                 310                 315                 320 


Asp Val Gln Ala Arg Asp Leu Gly Pro Asn Pro Ile Pro Ala His Cys 
                325                 330                 335     


Lys Val Leu Ile Lys Val Leu Asp Val Asn Asp Asn Ile Pro Ser Ile 
            340                 345                 350         


His Val Thr Trp Ala Ser Gln Pro Ser Leu Val Ser Glu Ala Leu Pro 
        355                 360                 365             


Lys Asp Ser Phe Ile Ala Leu Val Met Ala Asp Asp Leu Asp Ser Gly 
    370                 375                 380                 


His Asn Gly Leu Val His Cys Trp Leu Ser Gln Glu Leu Gly His Phe 
385                 390                 395                 400 


Arg Leu Lys Arg Thr Asn Gly Asn Thr Tyr Met Leu Leu Thr Asn Ala 
                405                 410                 415     


Thr Leu Asp Arg Glu Gln Trp Pro Lys Tyr Thr Leu Thr Leu Leu Ala 
            420                 425                 430         


Gln Asp Gln Gly Leu Gln Pro Leu Ser Ala Lys Lys Gln Leu Ser Ile 
        435                 440                 445             


Gln Ile Ser Asp Ile Asn Asp Asn Ala Pro Val Phe Glu Lys Ser Arg 
    450                 455                 460                 


Tyr Glu Val Ser Thr Arg Glu Asn Asn Leu Pro Ser Leu His Leu Ile 
465                 470                 475                 480 


Thr Ile Lys Ala His Asp Ala Asp Leu Gly Ile Asn Gly Lys Val Ser 
                485                 490                 495     


Tyr Arg Ile Gln Asp Ser Pro Val Ala His Leu Val Ala Ile Asp Ser 
            500                 505                 510         


Asn Thr Gly Glu Val Thr Ala Gln Arg Ser Leu Asn Tyr Glu Glu Met 
        515                 520                 525             


Ala Gly Phe Glu Phe Gln Val Ile Ala Glu Asp Ser Gly Gln Pro Met 
    530                 535                 540                 


Leu Ala Ser Ser Val Ser Val Trp Val Ser Leu Leu Asp Ala Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Glu Val Val Gln Pro Val Leu Ser Asp Gly Lys Ala Ser 
                565                 570                 575     


Leu Ser Val Leu Val Asn Ala Ser Thr Gly His Leu Leu Val Pro Ile 
            580                 585                 590         


Glu Thr Pro Asn Gly Leu Gly Pro Ala Gly Thr Asp Thr Pro Pro Leu 
        595                 600                 605             


Ala Thr His Ser Ser Arg Pro Phe Leu Leu Thr Thr Ile Val Ala Arg 
    610                 615                 620                 


Asp Ala Asp Ser Gly Ala Asn Gly Glu Pro Leu Tyr Ser Ile Arg Ser 
625                 630                 635                 640 


Gly Asn Glu Ala His Leu Phe Ile Leu Asn Pro His Thr Gly Gln Leu 
                645                 650                 655     


Phe Val Asn Val Thr Asn Ala Ser Ser Leu Ile Gly Ser Glu Trp Glu 
            660                 665                 670         


Leu Glu Ile Val Val Glu Asp Gln Gly Ser Pro Pro Leu Gln Thr Arg 
        675                 680                 685             


Ala Leu Leu Arg Val Met Phe Val Thr Ser Val Asp His Leu Arg Asp 
    690                 695                 700                 


Ser Ala Arg Lys Pro Gly Ala Leu Ser Met Ser Met Leu Thr Val Ile 
705                 710                 715                 720 


Cys Leu Ala Val Leu Leu Gly Ile Phe Gly Leu Ile Leu Ala Leu Phe 
                725                 730                 735     


Met Ser Ile Cys Arg Thr Glu Lys Lys Asp Asn Arg Ala Tyr Asn Cys 
            740                 745                 750         


Arg Glu Ala Glu Ser Thr Tyr Arg Gln Gln Pro Lys Arg Pro Gln Lys 
        755                 760                 765             


His Ile Gln Lys Ala Asp Ile His Leu Val Pro Val Leu Arg Gly Gln 
    770                 775                 780                 


Ala Gly Glu Pro Cys Glu Val Gly Gln Ser His Lys Asp Val Asp Lys 
785                 790                 795                 800 


Glu Ala Met Met Glu Ala Gly Trp Asp Pro Cys Leu Gln Ala Pro Phe 
                805                 810                 815     


His Leu Thr Pro Thr Leu Tyr Arg Thr Leu Arg Asn Gln Gly Asn Gln 
            820                 825                 830         


Gly Ala Pro Ala Glu Ser Arg Glu Val Leu Gln Asp Thr Val Asn Leu 
        835                 840                 845             


Leu Phe Asn His Pro Arg Gln Arg Asn Ala Ser Arg Glu Asn Leu Asn 
    850                 855                 860                 


Leu Pro Glu Pro Gln Pro Ala Thr Gly Gln Pro Arg Ser Arg Pro Leu 
865                 870                 875                 880 


Lys Val Ala Gly Ser Pro Thr Gly Arg Leu Ala Gly Asp Gln Gly Ser 
                885                 890                 895     


Glu Glu Ala Pro Gln Arg Pro Pro Ala Ser Ser Ala Thr Leu Arg Arg 
            900                 905                 910         


Gln Arg His Leu Asn Gly Lys Val Ser Pro Glu Lys Glu Ser Gly Pro 
        915                 920                 925             


Arg Gln Ile Leu Arg Ser Leu Val Arg Leu Ser Val Ala Ala Phe Ala 
    930                 935                 940                 


Glu Arg Asn Pro Val Glu Glu Leu Thr Val Asp Ser Pro Pro Val Gln 
945                 950                 955                 960 


Gln Ile Ser Gln Leu Leu Ser Leu Leu His Gln Gly Gln Phe Gln Pro 
                965                 970                 975     


Lys Pro Asn His Arg Gly Asn Lys Tyr Leu Ala Lys Pro Gly Gly Ser 
            980                 985                 990         


Arg Ser Ala Ile Pro Asp Thr Asp  Gly Pro Ser Ala Arg  Ala Gly Gly 
        995                 1000                 1005             


Gln Thr  Asp Pro Glu Gln Glu  Glu Gly Pro Leu Asp  Pro Glu Glu 
    1010                 1015                 1020             


Asp Leu  Ser Val Lys Gln Leu  Leu Glu Glu Glu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Leu Asp  Pro Ser Thr Gly Leu  Ala Leu Asp Arg Leu  Ser Ala Pro 
    1040                 1045                 1050             


Asp Pro  Ala Trp Met Ala Arg  Leu Ser Leu Pro Leu  Thr Thr Asn 
    1055                 1060                 1065             


Tyr Arg  Asp Asn Val Ile Ser  Pro Asp Ala Ala Ala  Thr Glu Glu 
    1070                 1075                 1080             


Pro Arg  Thr Phe Gln Thr Phe  Gly Lys Ala Glu Ala  Pro Glu Leu 
    1085                 1090                 1095             


Ser Pro  Thr Gly Thr Arg Leu  Ala Ser Thr Phe Val  Ser Glu Met 
    1100                 1105                 1110             


Ser Ser  Leu Leu Glu Met Leu  Leu Glu Gln Arg Ser  Ser Met Pro 
    1115                 1120                 1125             


Val Glu  Ala Ala Ser Glu Ala  Leu Arg Arg Leu Ser  Val Cys Gly 
    1130                 1135                 1140             


Arg Thr  Leu Ser Leu Asp Leu  Ala Thr Ser Ala Ala  Ser Gly Met 
    1145                 1150                 1155             


Lys Val  Gln Gly Asp Pro Gly  Gly Lys Thr Gly Thr  Glu Gly Lys 
    1160                 1165                 1170             


Ser Arg  Gly Ser Ser Ser Ser  Ser Arg Cys Leu 
    1175                 1180                 


<210>  10053
<211>  460
<212>  PRT
<213>  Homo Sapiens

<400>  10053

Leu Val Glu Lys Lys Ile Glu Asp Leu Thr Glu Ile Leu Asp Arg Tyr 
1               5                   10                  15      


Val Gln Glu Gln Ile Pro Gly Ala Lys Val Val Val Glu Ser Ile Gly 
            20                  25                  30          


Ala Arg Arg His Gly Asp Ala Phe Ser Leu Glu Asp Tyr Thr Lys Cys 
        35                  40                  45              


Asp Leu Thr Val Tyr Ala Ile Asp Pro Gln Thr Asn Arg Ala Ile Asp 
    50                  55                  60                  


Arg Asn Glu Leu Phe Lys Phe Leu Asp Gly Lys Leu Leu Asp Ile Asn 
65                  70                  75                  80  


Lys Asp Phe Gln Pro Tyr Tyr Gly Glu Gly Gly Arg Ile Leu Glu Ile 
                85                  90                  95      


Arg Thr Pro Glu Ala Val Thr Ser Ile Lys Lys Arg Gly Glu Ser Leu 
            100                 105                 110         


Gly Tyr Thr Glu Gly Ala Leu Leu Ala Leu Ala Phe Ile Ile Ile Leu 
        115                 120                 125             


Cys Cys Ile Pro Ala Ile Leu Val Val Leu Val Ser Tyr Arg Gln Phe 
    130                 135                 140                 


Lys Val Arg Gln Ala Glu Cys Thr Lys Thr Ala Arg Ile Gln Ala Ala 
145                 150                 155                 160 


Leu Pro Ala Ala Lys Pro Ala Val Pro Ala Pro Ala Pro Val Ala Ala 
                165                 170                 175     


Pro Pro Pro Pro Pro Pro Pro Pro Pro Gly Ala His Leu Tyr Glu Glu 
            180                 185                 190         


Leu Gly Asp Ser Ser Met Arg Gly Tyr Gly Ser Glu Gln Gln Gln Leu 
        195                 200                 205             


Leu Arg Pro Ser Leu Leu Lys Pro Glu Glu Leu Ser Met Glu Ser Gly 
    210                 215                 220                 


Ile Asp Pro Gly Gln Glu Tyr Gly Gln Asp Tyr Tyr Ser Tyr Glu His 
225                 230                 235                 240 


Gly Tyr Glu Met Pro Gln Tyr Gly Ser Arg Arg Arg Leu Leu Pro Pro 
                245                 250                 255     


Ala Gly Gln Glu Glu Tyr Gly Glu Val Val Gly Glu Ala Glu Glu Glu 
            260                 265                 270         


Tyr Glu Glu Glu Glu Trp Ala Arg Lys Arg Met Ile Lys Leu Val Val 
        275                 280                 285             


Asp Arg Glu Tyr Glu Thr Ser Ser Thr Gly Glu Asp Ser Ala Pro Glu 
    290                 295                 300                 


Cys Gln Arg Asn Arg Leu His His Pro Ser Ile His Ser Asn Ile Asn 
305                 310                 315                 320 


Gly Asn Ile Tyr Ile Ala Gln Asn Gly Ser Val Val Arg Thr Arg Arg 
                325                 330                 335     


Ala Cys Leu Thr Asp Asn Leu Lys Val Ala Ser Pro Val Arg Leu Gly 
            340                 345                 350         


Gly Pro Phe Lys Lys Leu Asp Lys Leu Ala Val Thr His Glu Glu Asn 
        355                 360                 365             


Val Pro Leu Asn Thr Leu Ser Lys Gly Pro Phe Ser Thr Glu Lys Met 
    370                 375                 380                 


Asn Ala Arg Pro Thr Leu Val Thr Phe Ala Pro Cys Pro Val Gly Thr 
385                 390                 395                 400 


Asp Asn Thr Ala Val Lys Pro Leu Arg Asn Arg Leu Lys Ser Thr Val 
                405                 410                 415     


Glu Gln Glu Ser Met Ile Asp Ser Lys Asn Ile Lys Glu Ala Leu Glu 
            420                 425                 430         


Phe His Ser Asp His Thr Gln Ser Asp Asp Glu Glu Leu Trp Met Gly 
        435                 440                 445             


Pro Trp Asn Asn Leu His Ile Pro Met Thr Lys Leu 
    450                 455                 460 


<210>  10054
<211>  92
<212>  PRT
<213>  Homo Sapiens

<400>  10054

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Cys 
            20                  25                  30          


Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile Val Ala Ile Asp Glu 
        35                  40                  45              


Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn Met Leu Ile Lys Gly 
    50                  55                  60                  


Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu Ser Leu Lys Asp Asn 
65                  70                  75                  80  


Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys Gln 
                85                  90          


<210>  10055
<211>  1915
<212>  PRT
<213>  Homo Sapiens

<400>  10055

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Cys 
            20                  25                  30          


Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile Val Ala Ile Asp Glu 
        35                  40                  45              


Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn Met Leu Ile Lys Gly 
    50                  55                  60                  


Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu Ser Leu Lys Asp Asn 
65                  70                  75                  80  


Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys Gln Met Leu Phe Leu 
                85                  90                  95      


Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro Pro Met Asn Ile His 
            100                 105                 110         


Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys Lys Val Gly Thr Ile 
        115                 120                 125             


Ile Tyr His Glu Val Arg Ile Val Val Arg Asp Arg Asn Asp Asn Ser 
    130                 135                 140                 


Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr Val Asn Glu Leu Thr 
145                 150                 155                 160 


Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser Gly Asp Asn Gly Ala 
                165                 170                 175     


Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile Glu Tyr Val Ile Gln 
            180                 185                 190         


Tyr Asn Pro Asp Asp Pro Asp Arg Ala Gln Asn Leu Asn Glu Arg Arg 
        195                 200                 205             


Thr Thr Thr Thr Thr Leu Thr Val Asp Val Leu Asp Gly Asp Asp Leu 
    210                 215                 220                 


Gly Pro Met Phe Leu Pro Cys Val Leu Val Pro Asn Thr Arg Asp Cys 
225                 230                 235                 240 


Arg Pro Leu Thr Tyr Gln Ala Ala Ile Pro Glu Leu Arg Thr Pro Glu 
                245                 250                 255     


Glu Leu Asn Pro Ile Ile Val Thr Pro Pro Ile Gln Ala Ile Asp Gln 
            260                 265                 270         


Asp Arg Asn Ile Gln Pro Pro Ser Asp Arg Pro Gly Ile Leu Tyr Ser 
        275                 280                 285             


Ile Leu Val Gly Thr Pro Glu Asp Tyr Pro Arg Phe Phe His Met His 
    290                 295                 300                 


Pro Arg Thr Ala Glu Leu Ser Leu Leu Glu Pro Val Asn Arg Asp Phe 
305                 310                 315                 320 


His Gln Lys Phe Asp Leu Val Ile Lys Ala Glu Gln Asp Asn Gly His 
                325                 330                 335     


Pro Leu Pro Ala Phe Ala Gly Leu His Ile Glu Ile Leu Asp Glu Asn 
            340                 345                 350         


Asn Gln Ser Pro Tyr Phe Thr Met Pro Ser Tyr Gln Gly Tyr Ile Leu 
        355                 360                 365             


Glu Ser Ala Pro Val Gly Ala Thr Ile Ser Asp Ser Leu Asn Leu Thr 
    370                 375                 380                 


Ser Pro Leu Arg Ile Val Ala Leu Asp Lys Asp Ile Glu Asp Thr Lys 
385                 390                 395                 400 


Asp Pro Glu Leu His Leu Phe Leu Asn Asp Tyr Thr Ser Val Phe Thr 
                405                 410                 415     


Val Thr Gln Thr Gly Ile Thr Arg Tyr Leu Thr Leu Leu Gln Pro Val 
            420                 425                 430         


Asp Arg Glu Glu Gln Gln Thr Tyr Thr Phe Ser Ile Thr Ala Phe Asp 
        435                 440                 445             


Gly Val Gln Glu Ser Glu Pro Val Ile Val Asn Ile Gln Val Met Asp 
    450                 455                 460                 


Ala Asn Asp Asn Thr Pro Thr Phe Pro Glu Ile Ser Tyr Asp Val Tyr 
465                 470                 475                 480 


Val Tyr Thr Asp Met Arg Pro Gly Asp Ser Val Ile Gln Leu Thr Ala 
                485                 490                 495     


Val Asp Ala Asp Glu Gly Ser Asn Gly Glu Ile Thr Tyr Glu Ile Leu 
            500                 505                 510         


Val Gly Ala Gln Gly Asp Phe Ile Ile Asn Lys Thr Thr Gly Leu Ile 
        515                 520                 525             


Thr Ile Ala Pro Gly Val Glu Met Ile Val Gly Arg Thr Tyr Ala Leu 
    530                 535                 540                 


Thr Val Gln Ala Ala Asp Asn Ala Pro Pro Ala Glu Arg Arg Asn Ser 
545                 550                 555                 560 


Ile Cys Thr Val Tyr Ile Glu Val Leu Pro Pro Asn Asn Gln Ser Pro 
                565                 570                 575     


Pro Arg Phe Pro Gln Leu Met Tyr Ser Leu Glu Ile Ser Glu Ala Met 
            580                 585                 590         


Arg Val Gly Ala Val Leu Leu Asn Leu Gln Ala Thr Asp Arg Glu Gly 
        595                 600                 605             


Asp Ser Ile Thr Tyr Ala Ile Glu Asn Gly Asp Pro Gln Arg Val Phe 
    610                 615                 620                 


Asn Leu Ser Glu Thr Thr Gly Ile Leu Thr Leu Gly Lys Ala Leu Asp 
625                 630                 635                 640 


Arg Glu Ser Thr Asp Arg Tyr Ile Leu Ile Ile Thr Ala Ser Asp Gly 
                645                 650                 655     


Arg Pro Asp Gly Thr Ser Thr Ala Thr Val Asn Ile Val Val Thr Asp 
            660                 665                 670         


Val Asn Asp Asn Ala Pro Val Phe Asp Pro Tyr Leu Pro Arg Asn Leu 
        675                 680                 685             


Ser Val Val Glu Glu Glu Ala Asn Ala Phe Val Gly Gln Val Lys Ala 
    690                 695                 700                 


Thr Asp Pro Asp Ala Gly Ile Asn Gly Gln Val His Tyr Ser Leu Gly 
705                 710                 715                 720 


Asn Phe Asn Asn Leu Phe Arg Ile Thr Ser Asn Gly Ser Ile Tyr Thr 
                725                 730                 735     


Ala Val Lys Leu Asn Arg Glu Val Arg Asp Tyr Tyr Glu Leu Val Val 
            740                 745                 750         


Val Ala Thr Asp Gly Ala Val His Pro Arg His Ser Thr Leu Thr Leu 
        755                 760                 765             


Ala Ile Lys Val Leu Asp Ile Asp Asp Asn Ser Pro Val Phe Thr Asn 
    770                 775                 780                 


Ser Thr Tyr Thr Val Leu Val Glu Glu Asn Leu Pro Ala Gly Thr Thr 
785                 790                 795                 800 


Ile Leu Gln Ile Glu Ala Lys Asp Val Asp Leu Gly Ala Asn Val Ser 
                805                 810                 815     


Tyr Arg Ile Arg Ser Pro Glu Val Lys His Phe Phe Ala Leu His Pro 
            820                 825                 830         


Phe Thr Gly Glu Leu Ser Leu Leu Arg Ser Leu Asp Tyr Glu Ala Phe 
        835                 840                 845             


Pro Asp Gln Glu Ala Ser Ile Thr Phe Leu Val Glu Ala Phe Asp Ile 
    850                 855                 860                 


Tyr Gly Thr Met Pro Pro Gly Ile Ala Thr Val Thr Val Ile Val Lys 
865                 870                 875                 880 


Asp Met Asn Asp Tyr Pro Pro Val Phe Ser Lys Arg Ile Tyr Lys Gly 
                885                 890                 895     


Met Val Ala Pro Asp Ala Val Lys Gly Thr Pro Ile Thr Thr Val Tyr 
            900                 905                 910         


Ala Glu Asp Ala Asp Pro Pro Gly Leu Pro Ala Ser Arg Val Arg Tyr 
        915                 920                 925             


Arg Val Asp Asp Val Gln Phe Pro Tyr Pro Ala Ser Ile Phe Glu Val 
    930                 935                 940                 


Glu Glu Asp Ser Gly Arg Val Ile Thr Arg Val Asn Leu Asn Glu Glu 
945                 950                 955                 960 


Pro Thr Thr Ile Phe Lys Leu Val Val Val Ala Phe Asp Asp Gly Glu 
                965                 970                 975     


Pro Val Met Ser Ser Ser Ala Thr Val Lys Ile Leu Val Leu His Pro 
            980                 985                 990         


Gly Glu Ile Pro Arg Phe Thr Gln  Glu Glu Tyr Arg Pro  Pro Pro Val 
        995                 1000                 1005             


Ser Glu  Leu Ala Thr Lys Gly  Thr Met Val Gly Val  Ile Ser Ala 
    1010                 1015                 1020             


Ala Ala  Ile Asn Gln Ser Ile  Val Tyr Ser Ile Val  Ser Gly Asn 
    1025                 1030                 1035             


Glu Glu  Asp Thr Phe Gly Ile  Asn Asn Ile Thr Gly  Val Ile Tyr 
    1040                 1045                 1050             


Val Asn  Gly Pro Leu Asp Tyr  Glu Thr Arg Thr Ser  Tyr Val Leu 
    1055                 1060                 1065             


Arg Val  Gln Ala Asp Ser Leu  Glu Val Val Leu Ala  Asn Leu Arg 
    1070                 1075                 1080             


Val Pro  Ser Lys Ser Asn Thr  Ala Lys Val Tyr Ile  Glu Ile Gln 
    1085                 1090                 1095             


Asp Glu  Asn Asn His Pro Pro  Val Phe Gln Lys Lys  Phe Tyr Ile 
    1100                 1105                 1110             


Gly Gly  Val Ser Glu Asp Ala  Arg Met Phe Thr Ser  Val Leu Arg 
    1115                 1120                 1125             


Val Lys  Ala Thr Asp Lys Asp  Thr Gly Asn Tyr Ser  Val Met Ala 
    1130                 1135                 1140             


Tyr Arg  Leu Ile Ile Pro Pro  Ile Lys Glu Gly Lys  Glu Gly Phe 
    1145                 1150                 1155             


Val Val  Glu Thr Tyr Thr Gly  Leu Ile Lys Thr Ala  Met Leu Phe 
    1160                 1165                 1170             


His Asn  Met Arg Arg Ser Tyr  Phe Lys Phe Gln Val  Ile Ala Thr 
    1175                 1180                 1185             


Asp Asp  Tyr Gly Lys Gly Leu  Ser Gly Lys Ala Asp  Val Leu Val 
    1190                 1195                 1200             


Ser Val  Val Asn Gln Leu Asp  Met Gln Val Ile Val  Ser Asn Val 
    1205                 1210                 1215             


Pro Pro  Thr Leu Val Glu Lys  Lys Ile Glu Asp Leu  Thr Glu Ile 
    1220                 1225                 1230             


Leu Asp  Arg Tyr Val Gln Glu  Gln Ile Pro Gly Ala  Lys Val Val 
    1235                 1240                 1245             


Val Glu  Ser Ile Gly Ala Arg  Arg His Gly Asp Ala  Phe Ser Leu 
    1250                 1255                 1260             


Glu Asp  Tyr Thr Lys Cys Asp  Leu Thr Val Tyr Ala  Ile Asp Pro 
    1265                 1270                 1275             


Gln Thr  Asn Arg Ala Ile Asp  Arg Asn Glu Leu Phe  Lys Phe Leu 
    1280                 1285                 1290             


Asp Gly  Lys Leu Leu Asp Ile  Asn Lys Asp Phe Gln  Pro Tyr Tyr 
    1295                 1300                 1305             


Gly Glu  Gly Gly Arg Ile Leu  Glu Ile Arg Thr Pro  Glu Ala Val 
    1310                 1315                 1320             


Thr Ser  Ile Lys Lys Arg Gly  Glu Ser Leu Gly Tyr  Thr Glu Gly 
    1325                 1330                 1335             


Ala Leu  Leu Ala Leu Ala Phe  Ile Ile Ile Leu Cys  Cys Ile Pro 
    1340                 1345                 1350             


Ala Ile  Leu Val Val Leu Val  Ser Tyr Arg Gln Arg  Gln Ala Glu 
    1355                 1360                 1365             


Cys Thr  Lys Thr Ala Arg Ile  Gln Ala Ala Leu Pro  Ala Ala Lys 
    1370                 1375                 1380             


Pro Ala  Val Pro Ala Pro Ala  Pro Val Ala Ala Pro  Pro Pro Pro 
    1385                 1390                 1395             


Pro Pro  Pro Pro Pro Gly Ala  His Leu Tyr Glu Glu  Leu Gly Asp 
    1400                 1405                 1410             


Ser Ser  Ile Leu Phe Leu Leu  Tyr His Phe Gln Gln  Ser Arg Gly 
    1415                 1420                 1425             


Asn Asn  Ser Val Ser Glu Asp  Arg Lys His Gln Gln  Val Val Met 
    1430                 1435                 1440             


Pro Phe  Ser Ser Asn Thr Ile  Glu Ala His Lys Ser  Ala His Val 
    1445                 1450                 1455             


Asp Gly  Ser Leu Lys Ser Asn  Lys Leu Lys Ser Ala  Arg Lys Phe 
    1460                 1465                 1470             


Thr Phe  Leu Ser Asp Glu Asp  Asp Leu Ser Ala His  Asn Pro Leu 
    1475                 1480                 1485             


Tyr Lys  Glu Asn Ile Ser Gln  Val Ser Thr Asn Ser  Asp Ile Ser 
    1490                 1495                 1500             


Gln Arg  Thr Asp Phe Val Asp  Pro Phe Ser Pro Lys  Ile Gln Ala 
    1505                 1510                 1515             


Lys Ser  Lys Ser Leu Arg Gly  Pro Arg Glu Lys Ile  Gln Arg Leu 
    1520                 1525                 1530             


Trp Ser  Gln Ser Val Ser Leu  Pro Arg Arg Leu Met  Arg Lys Val 
    1535                 1540                 1545             


Pro Asn  Arg Pro Glu Ile Ile  Asp Leu Gln Gln Trp  Gln Gly Thr 
    1550                 1555                 1560             


Arg Gln  Lys Ala Glu Asn Glu  Asn Thr Gly Ile Cys  Thr Asn Lys 
    1565                 1570                 1575             


Arg Gly  Ser Ser Asn Pro Leu  Leu Thr Thr Glu Glu  Ala Asn Leu 
    1580                 1585                 1590             


Thr Glu  Lys Glu Glu Ile Arg  Gln Gly Glu Thr Leu  Met Ile Glu 
    1595                 1600                 1605             


Gly Thr  Glu Gln Leu Lys Ser  Leu Ser Ser Asp Ser  Ser Phe Cys 
    1610                 1615                 1620             


Phe Pro  Arg Pro His Phe Ser  Phe Ser Thr Leu Pro  Thr Val Ser 
    1625                 1630                 1635             


Arg Thr  Val Glu Leu Lys Ser  Glu Pro Asn Val Ile  Ser Ser Pro 
    1640                 1645                 1650             


Ala Glu  Cys Ser Leu Glu Leu  Ser Pro Ser Arg Pro  Cys Val Leu 
    1655                 1660                 1665             


His Ser  Ser Leu Ser Arg Arg  Glu Thr Pro Ile Cys  Met Leu Pro 
    1670                 1675                 1680             


Ile Glu  Thr Glu Arg Asn Ile  Phe Glu Asn Phe Ala  His Pro Pro 
    1685                 1690                 1695             


Asn Ile  Ser Pro Ser Ala Cys  Pro Leu Pro Pro Pro  Pro Pro Ile 
    1700                 1705                 1710             


Ser Pro  Pro Ser Pro Pro Pro  Ala Pro Ala Pro Leu  Ala Pro Pro 
    1715                 1720                 1725             


Pro Asp  Ile Ser Pro Phe Ser  Leu Phe Cys Pro Pro  Pro Ser Pro 
    1730                 1735                 1740             


Pro Ser  Ile Pro Leu Pro Leu  Pro Pro Pro Thr Phe  Phe Pro Leu 
    1745                 1750                 1755             


Ser Val  Ser Thr Ser Gly Pro  Pro Thr Pro Pro Leu  Leu Pro Pro 
    1760                 1765                 1770             


Phe Pro  Thr Pro Leu Pro Pro  Pro Pro Pro Ser Ile  Pro Cys Pro 
    1775                 1780                 1785             


Pro Pro  Pro Ser Ala Ser Phe  Leu Ser Thr Glu Cys  Val Cys Ile 
    1790                 1795                 1800             


Thr Gly  Val Lys Cys Thr Thr  Asn Leu Met Pro Ala  Glu Lys Ile 
    1805                 1810                 1815             


Lys Ser  Ser Met Thr Gln Leu  Ser Thr Thr Thr Val  Cys Lys Thr 
    1820                 1825                 1830             


Asp Pro  Gln Arg Glu Pro Lys  Gly Ile Leu Arg His  Val Lys Asn 
    1835                 1840                 1845             


Leu Ala  Glu Leu Glu Lys Ser  Val Ala Asn Met Tyr  Ser Gln Ile 
    1850                 1855                 1860             


Glu Lys  Asn Tyr Leu Arg Thr  Asn Val Ser Glu Leu  Gln Thr Met 
    1865                 1870                 1875             


Cys Pro  Ser Glu Val Thr Asn  Met Glu Ile Thr Ser  Glu Gln Asn 
    1880                 1885                 1890             


Lys Gly  Ser Leu Asn Asn Ile  Val Glu Gly Thr Glu  Lys Gln Ser 
    1895                 1900                 1905             


His Ser  Gln Ser Thr Ser Leu  
    1910                 1915 


<210>  10056
<211>  1955
<212>  PRT
<213>  Homo Sapiens

<400>  10056

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Cys 
            20                  25                  30          


Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile Val Ala Ile Asp Glu 
        35                  40                  45              


Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn Met Leu Ile Lys Gly 
    50                  55                  60                  


Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu Ser Leu Lys Asp Asn 
65                  70                  75                  80  


Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys Gln Met Leu Phe Leu 
                85                  90                  95      


Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro Pro Met Asn Ile His 
            100                 105                 110         


Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys Lys Val Gly Thr Ile 
        115                 120                 125             


Ile Tyr His Glu Val Arg Ile Val Val Arg Asp Arg Asn Asp Asn Ser 
    130                 135                 140                 


Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr Val Asn Glu Leu Thr 
145                 150                 155                 160 


Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser Gly Asp Asn Gly Ala 
                165                 170                 175     


Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile Glu Tyr Val Ile Gln 
            180                 185                 190         


Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr Phe Glu Ile Pro Leu 
        195                 200                 205             


Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg Leu Asn Tyr Glu Asp 
    210                 215                 220                 


Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn Asp Arg Ala Gln Asn 
225                 230                 235                 240 


Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu Thr Val Asp Val Leu 
                245                 250                 255     


Asp Gly Asp Asp Leu Gly Pro Met Phe Leu Pro Cys Val Leu Val Pro 
            260                 265                 270         


Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln Ala Ala Ile Pro Glu 
        275                 280                 285             


Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile Val Thr Pro Pro Ile 
    290                 295                 300                 


Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro Pro Ser Asp Arg Pro 
305                 310                 315                 320 


Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro Glu Asp Tyr Pro Arg 
                325                 330                 335     


Phe Phe His Met His Pro Arg Thr Ala Glu Leu Ser Leu Leu Glu Pro 
            340                 345                 350         


Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu Val Ile Lys Ala Glu 
        355                 360                 365             


Gln Asp Asn Gly His Pro Leu Pro Ala Phe Ala Gly Leu His Ile Glu 
    370                 375                 380                 


Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe Thr Met Pro Ser Tyr 
385                 390                 395                 400 


Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly Ala Thr Ile Ser Asp 
                405                 410                 415     


Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val Ala Leu Asp Lys Asp 
            420                 425                 430         


Ile Glu Asp Thr Lys Asp Pro Glu Leu His Leu Phe Leu Asn Asp Tyr 
        435                 440                 445             


Thr Ser Val Phe Thr Val Thr Gln Thr Gly Ile Thr Arg Tyr Leu Thr 
    450                 455                 460                 


Leu Leu Gln Pro Val Asp Arg Glu Glu Gln Gln Thr Tyr Thr Phe Ser 
465                 470                 475                 480 


Ile Thr Ala Phe Asp Gly Val Gln Glu Ser Glu Pro Val Ile Val Asn 
                485                 490                 495     


Ile Gln Val Met Asp Ala Asn Asp Asn Thr Pro Thr Phe Pro Glu Ile 
            500                 505                 510         


Ser Tyr Asp Val Tyr Val Tyr Thr Asp Met Arg Pro Gly Asp Ser Val 
        515                 520                 525             


Ile Gln Leu Thr Ala Val Asp Ala Asp Glu Gly Ser Asn Gly Glu Ile 
    530                 535                 540                 


Thr Tyr Glu Ile Leu Val Gly Ala Gln Gly Asp Phe Ile Ile Asn Lys 
545                 550                 555                 560 


Thr Thr Gly Leu Ile Thr Ile Ala Pro Gly Val Glu Met Ile Val Gly 
                565                 570                 575     


Arg Thr Tyr Ala Leu Thr Val Gln Ala Ala Asp Asn Ala Pro Pro Ala 
            580                 585                 590         


Glu Arg Arg Asn Ser Ile Cys Thr Val Tyr Ile Glu Val Leu Pro Pro 
        595                 600                 605             


Asn Asn Gln Ser Pro Pro Arg Phe Pro Gln Leu Met Tyr Ser Leu Glu 
    610                 615                 620                 


Ile Ser Glu Ala Met Arg Val Gly Ala Val Leu Leu Asn Leu Gln Ala 
625                 630                 635                 640 


Thr Asp Arg Glu Gly Asp Ser Ile Thr Tyr Ala Ile Glu Asn Gly Asp 
                645                 650                 655     


Pro Gln Arg Val Phe Asn Leu Ser Glu Thr Thr Gly Ile Leu Thr Leu 
            660                 665                 670         


Gly Lys Ala Leu Asp Arg Glu Ser Thr Asp Arg Tyr Ile Leu Ile Ile 
        675                 680                 685             


Thr Ala Ser Asp Gly Arg Pro Asp Gly Thr Ser Thr Ala Thr Val Asn 
    690                 695                 700                 


Ile Val Val Thr Asp Val Asn Asp Asn Ala Pro Val Phe Asp Pro Tyr 
705                 710                 715                 720 


Leu Pro Arg Asn Leu Ser Val Val Glu Glu Glu Ala Asn Ala Phe Val 
                725                 730                 735     


Gly Gln Val Lys Ala Thr Asp Pro Asp Ala Gly Ile Asn Gly Gln Val 
            740                 745                 750         


His Tyr Ser Leu Gly Asn Phe Asn Asn Leu Phe Arg Ile Thr Ser Asn 
        755                 760                 765             


Gly Ser Ile Tyr Thr Ala Val Lys Leu Asn Arg Glu Val Arg Asp Tyr 
    770                 775                 780                 


Tyr Glu Leu Val Val Val Ala Thr Asp Gly Ala Val His Pro Arg His 
785                 790                 795                 800 


Ser Thr Leu Thr Leu Ala Ile Lys Val Leu Asp Ile Asp Asp Asn Ser 
                805                 810                 815     


Pro Val Phe Thr Asn Ser Thr Tyr Thr Val Leu Val Glu Glu Asn Leu 
            820                 825                 830         


Pro Ala Gly Thr Thr Ile Leu Gln Ile Glu Ala Lys Asp Val Asp Leu 
        835                 840                 845             


Gly Ala Asn Val Ser Tyr Arg Ile Arg Ser Pro Glu Val Lys His Phe 
    850                 855                 860                 


Phe Ala Leu His Pro Phe Thr Gly Glu Leu Ser Leu Leu Arg Ser Leu 
865                 870                 875                 880 


Asp Tyr Glu Ala Phe Pro Asp Gln Glu Ala Ser Ile Thr Phe Leu Val 
                885                 890                 895     


Glu Ala Phe Asp Ile Tyr Gly Thr Met Pro Pro Gly Ile Ala Thr Val 
            900                 905                 910         


Thr Val Ile Val Lys Asp Met Asn Asp Tyr Pro Pro Val Phe Ser Lys 
        915                 920                 925             


Arg Ile Tyr Lys Gly Met Val Ala Pro Asp Ala Val Lys Gly Thr Pro 
    930                 935                 940                 


Ile Thr Thr Val Tyr Ala Glu Asp Ala Asp Pro Pro Gly Leu Pro Ala 
945                 950                 955                 960 


Ser Arg Val Arg Tyr Arg Val Asp Asp Val Gln Phe Pro Tyr Pro Ala 
                965                 970                 975     


Ser Ile Phe Glu Val Glu Glu Asp Ser Gly Arg Val Ile Thr Arg Val 
            980                 985                 990         


Asn Leu Asn Glu Glu Pro Thr Thr  Ile Phe Lys Leu Val  Val Val Ala 
        995                 1000                 1005             


Phe Asp  Asp Gly Glu Pro Val  Met Ser Ser Ser Ala  Thr Val Lys 
    1010                 1015                 1020             


Ile Leu  Val Leu His Pro Gly  Glu Ile Pro Arg Phe  Thr Gln Glu 
    1025                 1030                 1035             


Glu Tyr  Arg Pro Pro Pro Val  Ser Glu Leu Ala Thr  Lys Gly Thr 
    1040                 1045                 1050             


Met Val  Gly Val Ile Ser Ala  Ala Ala Ile Asn Gln  Ser Ile Val 
    1055                 1060                 1065             


Tyr Ser  Ile Val Ser Gly Asn  Glu Glu Asp Thr Phe  Gly Ile Asn 
    1070                 1075                 1080             


Asn Ile  Thr Gly Val Ile Tyr  Val Asn Gly Pro Leu  Asp Tyr Glu 
    1085                 1090                 1095             


Thr Arg  Thr Ser Tyr Val Leu  Arg Val Gln Ala Asp  Ser Leu Glu 
    1100                 1105                 1110             


Val Val  Leu Ala Asn Leu Arg  Val Pro Ser Lys Ser  Asn Thr Ala 
    1115                 1120                 1125             


Lys Val  Tyr Ile Glu Ile Gln  Asp Glu Asn Asn His  Pro Pro Val 
    1130                 1135                 1140             


Phe Gln  Lys Lys Phe Tyr Ile  Gly Gly Val Ser Glu  Asp Ala Arg 
    1145                 1150                 1155             


Met Phe  Thr Ser Val Leu Arg  Val Lys Ala Thr Asp  Lys Asp Thr 
    1160                 1165                 1170             


Gly Asn  Tyr Ser Val Met Ala  Tyr Arg Leu Ile Ile  Pro Pro Ile 
    1175                 1180                 1185             


Lys Glu  Gly Lys Glu Gly Phe  Val Val Glu Thr Tyr  Thr Gly Leu 
    1190                 1195                 1200             


Ile Lys  Thr Ala Met Leu Phe  His Asn Met Arg Arg  Ser Tyr Phe 
    1205                 1210                 1215             


Lys Phe  Gln Val Ile Ala Thr  Asp Asp Tyr Gly Lys  Gly Leu Ser 
    1220                 1225                 1230             


Gly Lys  Ala Asp Val Leu Val  Ser Val Val Asn Gln  Leu Asp Met 
    1235                 1240                 1245             


Gln Val  Ile Val Ser Asn Val  Pro Pro Thr Leu Val  Glu Lys Lys 
    1250                 1255                 1260             


Ile Glu  Asp Leu Thr Glu Ile  Leu Asp Arg Tyr Val  Gln Glu Gln 
    1265                 1270                 1275             


Ile Pro  Gly Ala Lys Val Val  Val Glu Ser Ile Gly  Ala Arg Arg 
    1280                 1285                 1290             


His Gly  Asp Ala Phe Ser Leu  Glu Asp Tyr Thr Lys  Cys Asp Leu 
    1295                 1300                 1305             


Thr Val  Tyr Ala Ile Asp Pro  Gln Thr Asn Arg Ala  Ile Asp Arg 
    1310                 1315                 1320             


Asn Glu  Leu Phe Lys Phe Leu  Asp Gly Lys Leu Leu  Asp Ile Asn 
    1325                 1330                 1335             


Lys Asp  Phe Gln Pro Tyr Tyr  Gly Glu Gly Gly Arg  Ile Leu Glu 
    1340                 1345                 1350             


Ile Arg  Thr Pro Glu Ala Val  Thr Ser Ile Lys Lys  Arg Gly Glu 
    1355                 1360                 1365             


Ser Leu  Gly Tyr Thr Glu Gly  Ala Leu Leu Ala Leu  Ala Phe Ile 
    1370                 1375                 1380             


Ile Ile  Leu Cys Cys Ile Pro  Ala Ile Leu Val Val  Leu Val Ser 
    1385                 1390                 1395             


Tyr Arg  Gln Phe Lys Val Arg  Gln Ala Glu Cys Thr  Lys Thr Ala 
    1400                 1405                 1410             


Arg Ile  Gln Ala Ala Leu Pro  Ala Ala Lys Pro Ala  Val Pro Ala 
    1415                 1420                 1425             


Pro Ala  Pro Val Ala Ala Pro  Pro Pro Pro Pro Pro  Pro Pro Pro 
    1430                 1435                 1440             


Gly Ala  His Leu Tyr Glu Glu  Leu Gly Asp Ser Ser  Ile Leu Phe 
    1445                 1450                 1455             


Leu Leu  Tyr His Phe Gln Gln  Ser Arg Gly Asn Asn  Ser Val Ser 
    1460                 1465                 1470             


Glu Asp  Arg Lys His Gln Gln  Val Val Met Pro Phe  Ser Ser Asn 
    1475                 1480                 1485             


Thr Ile  Glu Ala His Lys Ser  Ala His Val Asp Gly  Ser Leu Lys 
    1490                 1495                 1500             


Ser Asn  Lys Leu Lys Ser Ala  Arg Lys Phe Thr Phe  Leu Ser Asp 
    1505                 1510                 1515             


Glu Asp  Asp Leu Ser Ala His  Asn Pro Leu Tyr Lys  Glu Asn Ile 
    1520                 1525                 1530             


Ser Gln  Val Ser Thr Asn Ser  Asp Ile Ser Gln Arg  Thr Asp Phe 
    1535                 1540                 1545             


Val Asp  Pro Phe Ser Pro Lys  Ile Gln Ala Lys Ser  Lys Ser Leu 
    1550                 1555                 1560             


Arg Gly  Pro Arg Glu Lys Ile  Gln Arg Leu Trp Ser  Gln Ser Val 
    1565                 1570                 1575             


Ser Leu  Pro Arg Arg Leu Met  Arg Lys Val Pro Asn  Arg Pro Glu 
    1580                 1585                 1590             


Ile Ile  Asp Leu Gln Gln Trp  Gln Gly Thr Arg Gln  Lys Ala Glu 
    1595                 1600                 1605             


Asn Glu  Asn Thr Gly Ile Cys  Thr Asn Lys Arg Gly  Ser Ser Asn 
    1610                 1615                 1620             


Pro Leu  Leu Thr Thr Glu Glu  Ala Asn Leu Thr Glu  Lys Glu Glu 
    1625                 1630                 1635             


Ile Arg  Gln Gly Glu Thr Leu  Met Ile Glu Gly Thr  Glu Gln Leu 
    1640                 1645                 1650             


Lys Ser  Leu Ser Ser Asp Ser  Ser Phe Cys Phe Pro  Arg Pro His 
    1655                 1660                 1665             


Phe Ser  Phe Ser Thr Leu Pro  Thr Val Ser Arg Thr  Val Glu Leu 
    1670                 1675                 1680             


Lys Ser  Glu Pro Asn Val Ile  Ser Ser Pro Ala Glu  Cys Ser Leu 
    1685                 1690                 1695             


Glu Leu  Ser Pro Ser Arg Pro  Cys Val Leu His Ser  Ser Leu Ser 
    1700                 1705                 1710             


Arg Arg  Glu Thr Pro Ile Cys  Met Leu Pro Ile Glu  Thr Glu Arg 
    1715                 1720                 1725             


Asn Ile  Phe Glu Asn Phe Ala  His Pro Pro Asn Ile  Ser Pro Ser 
    1730                 1735                 1740             


Ala Cys  Pro Leu Pro Pro Pro  Pro Pro Ile Ser Pro  Pro Ser Pro 
    1745                 1750                 1755             


Pro Pro  Ala Pro Ala Pro Leu  Ala Pro Pro Pro Asp  Ile Ser Pro 
    1760                 1765                 1770             


Phe Ser  Leu Phe Cys Pro Pro  Pro Ser Pro Pro Ser  Ile Pro Leu 
    1775                 1780                 1785             


Pro Leu  Pro Pro Pro Thr Phe  Phe Pro Leu Ser Val  Ser Thr Ser 
    1790                 1795                 1800             


Gly Pro  Pro Thr Pro Pro Leu  Leu Pro Pro Phe Pro  Thr Pro Leu 
    1805                 1810                 1815             


Pro Pro  Pro Pro Pro Ser Ile  Pro Cys Pro Pro Pro  Pro Ser Ala 
    1820                 1825                 1830             


Ser Phe  Leu Ser Thr Glu Cys  Val Cys Ile Thr Gly  Val Lys Cys 
    1835                 1840                 1845             


Thr Thr  Asn Leu Met Pro Ala  Glu Lys Ile Lys Ser  Ser Met Thr 
    1850                 1855                 1860             


Gln Leu  Ser Thr Thr Thr Val  Cys Lys Thr Asp Pro  Gln Arg Glu 
    1865                 1870                 1875             


Pro Lys  Gly Ile Leu Arg His  Val Lys Asn Leu Ala  Glu Leu Glu 
    1880                 1885                 1890             


Lys Ser  Val Ala Asn Met Tyr  Ser Gln Ile Glu Lys  Asn Tyr Leu 
    1895                 1900                 1905             


Arg Thr  Asn Val Ser Glu Leu  Gln Thr Met Cys Pro  Ser Glu Val 
    1910                 1915                 1920             


Thr Asn  Met Glu Ile Thr Ser  Glu Gln Asn Lys Gly  Ser Leu Asn 
    1925                 1930                 1935             


Asn Ile  Val Glu Gly Thr Glu  Lys Gln Ser His Ser  Gln Ser Thr 
    1940                 1945                 1950             


Ser Leu  
    1955 


<210>  10057
<211>  961
<212>  PRT
<213>  Homo Sapiens

<400>  10057

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Cys 
            20                  25                  30          


Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile Val Ala Ile Asp Glu 
        35                  40                  45              


Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn Met Leu Ile Lys Gly 
    50                  55                  60                  


Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu Ser Leu Lys Asp Asn 
65                  70                  75                  80  


Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys Gln Met Leu Phe Leu 
                85                  90                  95      


Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro Pro Met Asn Ile His 
            100                 105                 110         


Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys Lys Val Gly Thr Ile 
        115                 120                 125             


Ile Tyr His Glu Val Arg Ile Val Val Arg Asp Arg Asn Asp Asn Ser 
    130                 135                 140                 


Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr Val Asn Glu Leu Thr 
145                 150                 155                 160 


Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser Gly Asp Asn Gly Ala 
                165                 170                 175     


Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile Glu Tyr Val Ile Gln 
            180                 185                 190         


Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr Phe Glu Ile Pro Leu 
        195                 200                 205             


Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg Leu Asn Tyr Glu Asp 
    210                 215                 220                 


Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn Asp Arg Ala Gln Asn 
225                 230                 235                 240 


Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu Thr Val Asp Val Leu 
                245                 250                 255     


Asp Gly Asp Asp Leu Gly Pro Met Phe Leu Pro Cys Val Leu Val Pro 
            260                 265                 270         


Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln Ala Ala Ile Pro Glu 
        275                 280                 285             


Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile Val Thr Pro Pro Ile 
    290                 295                 300                 


Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro Pro Ser Asp Arg Pro 
305                 310                 315                 320 


Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro Glu Asp Tyr Pro Arg 
                325                 330                 335     


Phe Phe His Met His Pro Arg Thr Ala Glu Leu Ser Leu Leu Glu Pro 
            340                 345                 350         


Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu Val Ile Lys Ala Glu 
        355                 360                 365             


Gln Asp Asn Gly His Pro Leu Pro Ala Phe Ala Gly Leu His Ile Glu 
    370                 375                 380                 


Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe Thr Met Pro Ser Tyr 
385                 390                 395                 400 


Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly Ala Thr Ile Ser Asp 
                405                 410                 415     


Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val Ala Leu Asp Lys Asp 
            420                 425                 430         


Ile Glu Asp Thr Lys Asp Pro Glu Leu His Leu Phe Leu Asn Asp Tyr 
        435                 440                 445             


Thr Ser Val Phe Thr Val Thr Gln Thr Gly Ile Thr Arg Tyr Leu Thr 
    450                 455                 460                 


Leu Leu Gln Pro Val Asp Arg Glu Glu Gln Gln Thr Tyr Thr Phe Ser 
465                 470                 475                 480 


Ile Thr Ala Phe Asp Gly Val Gln Glu Ser Glu Pro Val Ile Val Asn 
                485                 490                 495     


Ile Gln Val Met Asp Ala Asn Asp Asn Thr Pro Thr Phe Pro Glu Ile 
            500                 505                 510         


Ser Tyr Asp Val Tyr Val Tyr Thr Asp Met Arg Pro Gly Asp Ser Val 
        515                 520                 525             


Ile Gln Leu Thr Ala Val Asp Ala Asp Glu Gly Ser Asn Gly Glu Ile 
    530                 535                 540                 


Thr Tyr Glu Ile Leu Val Gly Ala Gln Gly Asp Phe Ile Ile Asn Lys 
545                 550                 555                 560 


Thr Thr Gly Leu Ile Thr Ile Ala Pro Gly Val Glu Met Ile Val Gly 
                565                 570                 575     


Arg Thr Tyr Ala Leu Thr Val Gln Ala Ala Asp Asn Ala Pro Pro Ala 
            580                 585                 590         


Glu Arg Arg Asn Ser Ile Cys Thr Val Tyr Ile Glu Val Leu Pro Pro 
        595                 600                 605             


Asn Asn Gln Ser Pro Pro Arg Phe Pro Gln Leu Met Tyr Ser Leu Glu 
    610                 615                 620                 


Ile Ser Glu Ala Met Arg Val Gly Ala Val Leu Leu Asn Leu Gln Ala 
625                 630                 635                 640 


Thr Asp Arg Glu Gly Asp Ser Ile Thr Tyr Ala Ile Glu Asn Gly Asp 
                645                 650                 655     


Pro Gln Arg Val Phe Asn Leu Ser Glu Thr Thr Gly Ile Leu Thr Leu 
            660                 665                 670         


Gly Lys Ala Leu Asp Arg Glu Ser Thr Asp Arg Tyr Ile Leu Ile Ile 
        675                 680                 685             


Thr Ala Ser Asp Gly Arg Pro Asp Gly Thr Ser Thr Ala Thr Val Asn 
    690                 695                 700                 


Ile Val Val Thr Asp Val Asn Asp Asn Ala Pro Val Phe Asp Pro Tyr 
705                 710                 715                 720 


Leu Pro Arg Asn Leu Ser Val Val Glu Glu Glu Ala Asn Ala Phe Val 
                725                 730                 735     


Gly Gln Val Lys Ala Thr Asp Pro Asp Ala Gly Ile Asn Gly Gln Val 
            740                 745                 750         


His Tyr Ser Leu Gly Asn Phe Asn Asn Leu Phe Arg Ile Thr Ser Asn 
        755                 760                 765             


Gly Ser Ile Tyr Thr Ala Val Lys Leu Asn Arg Glu Val Arg Asp Tyr 
    770                 775                 780                 


Tyr Glu Leu Val Val Val Ala Thr Asp Gly Ala Val His Pro Arg His 
785                 790                 795                 800 


Ser Thr Leu Thr Leu Ala Ile Lys Val Leu Asp Ile Asp Asp Asn Ser 
                805                 810                 815     


Pro Val Phe Thr Asn Ser Thr Tyr Thr Val Leu Val Glu Glu Asn Leu 
            820                 825                 830         


Pro Ala Gly Thr Thr Ile Leu Gln Ile Glu Ala Lys Asp Val Asp Leu 
        835                 840                 845             


Gly Ala Asn Val Ser Tyr Arg Ile Arg Ser Pro Glu Val Lys His Phe 
    850                 855                 860                 


Phe Ala Leu His Pro Phe Thr Gly Glu Leu Ser Leu Leu Arg Ser Leu 
865                 870                 875                 880 


Asp Tyr Glu Ala Phe Pro Asp Gln Glu Ala Ser Ile Thr Phe Leu Val 
                885                 890                 895     


Glu Ala Phe Asp Ile Tyr Gly Thr Met Pro Pro Gly Ile Ala Thr Val 
            900                 905                 910         


Thr Val Ile Val Lys Asp Met Asn Asp Tyr Pro Pro Val Phe Ser Lys 
        915                 920                 925             


Arg Ile Tyr Lys Gly Met Val Ala Pro Asp Ala Val Lys Gly Thr Pro 
    930                 935                 940                 


Ile Thr Thr Val Tyr Ala Glu Asp Ala Asp Pro Pro Val Ser Arg Arg 
945                 950                 955                 960 


His 
    


<210>  10058
<211>  654
<212>  PRT
<213>  Homo Sapiens

<400>  10058

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Cys 
            20                  25                  30          


Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile Val Ala Ile Asp Glu 
        35                  40                  45              


Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn Met Leu Ile Lys Gly 
    50                  55                  60                  


Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu Ser Leu Lys Asp Asn 
65                  70                  75                  80  


Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys Gln Met Leu Phe Leu 
                85                  90                  95      


Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro Pro Met Asn Ile His 
            100                 105                 110         


Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys Lys Val Gly Thr Ile 
        115                 120                 125             


Ile Tyr His Glu Val Arg Ile Val Val Arg Asp Arg Asn Asp Asn Ser 
    130                 135                 140                 


Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr Val Asn Glu Leu Thr 
145                 150                 155                 160 


Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser Gly Asp Asn Gly Ala 
                165                 170                 175     


Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile Glu Tyr Val Ile Gln 
            180                 185                 190         


Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr Phe Glu Ile Pro Leu 
        195                 200                 205             


Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg Leu Asn Tyr Glu Asp 
    210                 215                 220                 


Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn Asp Arg Ala Gln Asn 
225                 230                 235                 240 


Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu Thr Val Asp Val Leu 
                245                 250                 255     


Asp Gly Asp Asp Leu Gly Pro Met Phe Leu Pro Cys Val Leu Val Pro 
            260                 265                 270         


Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln Ala Ala Ile Pro Glu 
        275                 280                 285             


Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile Val Thr Pro Pro Ile 
    290                 295                 300                 


Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro Pro Ser Asp Arg Pro 
305                 310                 315                 320 


Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro Glu Asp Tyr Pro Arg 
                325                 330                 335     


Phe Phe His Met His Pro Arg Thr Ala Glu Leu Ser Leu Leu Glu Pro 
            340                 345                 350         


Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu Val Ile Lys Ala Glu 
        355                 360                 365             


Gln Asp Asn Gly His Pro Leu Pro Ala Phe Ala Gly Leu His Ile Glu 
    370                 375                 380                 


Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe Thr Met Pro Ser Tyr 
385                 390                 395                 400 


Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly Ala Thr Ile Ser Asp 
                405                 410                 415     


Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val Ala Leu Asp Lys Asp 
            420                 425                 430         


Ile Glu Asp Thr Lys Asp Pro Glu Leu His Leu Phe Leu Asn Asp Tyr 
        435                 440                 445             


Thr Ser Val Phe Thr Val Thr Gln Thr Gly Ile Thr Arg Tyr Leu Thr 
    450                 455                 460                 


Leu Leu Gln Pro Val Asp Arg Glu Glu Gln Gln Thr Tyr Thr Phe Ser 
465                 470                 475                 480 


Ile Thr Ala Phe Asp Gly Val Gln Glu Ser Glu Pro Val Ile Val Asn 
                485                 490                 495     


Ile Gln Val Met Asp Ala Asn Asp Asn Thr Pro Thr Phe Pro Glu Ile 
            500                 505                 510         


Ser Tyr Asp Val Tyr Val Tyr Thr Asp Met Arg Pro Gly Asp Ser Val 
        515                 520                 525             


Ile Gln Leu Thr Ala Val Asp Ala Asp Glu Gly Ser Asn Gly Glu Ile 
    530                 535                 540                 


Thr Tyr Glu Ile Leu Val Gly Ala Gln Gly Asp Phe Ile Ile Asn Lys 
545                 550                 555                 560 


Thr Thr Gly Leu Ile Thr Ile Ala Pro Gly Val Glu Met Ile Val Gly 
                565                 570                 575     


Arg Thr Tyr Ala Leu Thr Val Gln Ala Ala Asp Asn Ala Pro Pro Ala 
            580                 585                 590         


Glu Arg Arg Asn Ser Ile Cys Thr Val Tyr Ile Glu Val Leu Pro Pro 
        595                 600                 605             


Asn Asn Gln Ser Pro Pro Arg Phe Pro Gln Leu Met Tyr Ser Leu Glu 
    610                 615                 620                 


Ile Ser Glu Ala Met Arg Val Gly Ala Val Leu Leu Asn Leu Gln His 
625                 630                 635                 640 


Gly Asp Ser Asn Leu Arg Glu Ser Thr Gly Gln Gly Lys His 
                645                 650                 


<210>  10059
<211>  1677
<212>  PRT
<213>  Homo Sapiens

<400>  10059

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Cys 
            20                  25                  30          


Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile Val Ala Ile Asp Glu 
        35                  40                  45              


Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn Met Leu Ile Lys Gly 
    50                  55                  60                  


Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu Ser Leu Lys Asp Asn 
65                  70                  75                  80  


Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys Gln Met Leu Phe Leu 
                85                  90                  95      


Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro Pro Met Asn Ile His 
            100                 105                 110         


Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys Lys Val Gly Thr Ile 
        115                 120                 125             


Ile Tyr His Glu Val Arg Ile Val Val Arg Asp Arg Asn Asp Asn Ser 
    130                 135                 140                 


Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr Val Asn Glu Leu Thr 
145                 150                 155                 160 


Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser Gly Asp Asn Gly Ala 
                165                 170                 175     


Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile Glu Tyr Val Ile Gln 
            180                 185                 190         


Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr Phe Glu Ile Pro Leu 
        195                 200                 205             


Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg Leu Asn Tyr Glu Asp 
    210                 215                 220                 


Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn Asp Arg Ala Gln Asn 
225                 230                 235                 240 


Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu Thr Val Asp Val Leu 
                245                 250                 255     


Asp Gly Asp Asp Leu Gly Pro Met Phe Leu Pro Cys Val Leu Val Pro 
            260                 265                 270         


Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln Ala Ala Ile Pro Glu 
        275                 280                 285             


Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile Val Thr Pro Pro Ile 
    290                 295                 300                 


Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro Pro Ser Asp Arg Pro 
305                 310                 315                 320 


Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro Glu Asp Tyr Pro Arg 
                325                 330                 335     


Phe Phe His Met His Pro Arg Thr Ala Glu Leu Ser Leu Leu Glu Pro 
            340                 345                 350         


Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu Val Ile Lys Ala Glu 
        355                 360                 365             


Gln Asp Asn Gly His Pro Leu Pro Ala Phe Ala Gly Leu His Ile Glu 
    370                 375                 380                 


Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe Thr Met Pro Ser Tyr 
385                 390                 395                 400 


Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly Ala Thr Ile Ser Asp 
                405                 410                 415     


Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val Ala Leu Asp Lys Asp 
            420                 425                 430         


Ile Glu Asp Thr Lys Asp Pro Glu Leu His Leu Phe Leu Asn Asp Tyr 
        435                 440                 445             


Thr Ser Val Phe Thr Val Thr Gln Thr Gly Ile Thr Arg Tyr Leu Thr 
    450                 455                 460                 


Leu Leu Gln Pro Val Asp Arg Glu Glu Gln Gln Thr Tyr Thr Phe Ser 
465                 470                 475                 480 


Ile Thr Ala Phe Asp Gly Val Gln Glu Ser Glu Pro Val Ile Val Asn 
                485                 490                 495     


Ile Gln Val Met Asp Ala Asn Asp Asn Thr Pro Thr Phe Pro Glu Ile 
            500                 505                 510         


Ser Tyr Asp Val Tyr Val Tyr Thr Asp Met Arg Pro Gly Asp Ser Val 
        515                 520                 525             


Ile Gln Leu Thr Ala Val Asp Ala Asp Glu Gly Ser Asn Gly Glu Ile 
    530                 535                 540                 


Thr Tyr Glu Ile Leu Val Gly Ala Gln Gly Asp Phe Ile Ile Asn Lys 
545                 550                 555                 560 


Thr Thr Gly Leu Ile Thr Ile Ala Pro Gly Val Glu Met Ile Val Gly 
                565                 570                 575     


Arg Thr Tyr Ala Leu Thr Val Gln Ala Ala Asp Asn Ala Pro Pro Ala 
            580                 585                 590         


Glu Arg Arg Asn Ser Ile Cys Thr Val Tyr Ile Glu Val Leu Pro Pro 
        595                 600                 605             


Asn Asn Gln Ser Pro Pro Arg Phe Pro Gln Leu Met Tyr Ser Leu Glu 
    610                 615                 620                 


Ile Ser Glu Ala Met Arg Val Gly Ala Val Leu Leu Asn Leu Gln Ala 
625                 630                 635                 640 


Thr Asp Arg Glu Gly Asp Ser Ile Thr Tyr Ala Ile Glu Asn Gly Asp 
                645                 650                 655     


Pro Gln Arg Val Phe Asn Leu Ser Glu Thr Thr Gly Ile Leu Thr Leu 
            660                 665                 670         


Gly Lys Ala Leu Asp Arg Glu Ser Thr Asp Arg Tyr Ile Leu Ile Ile 
        675                 680                 685             


Thr Ala Ser Asp Gly Arg Pro Asp Gly Thr Ser Thr Ala Thr Val Asn 
    690                 695                 700                 


Ile Val Val Thr Asp Val Asn Asp Asn Ala Pro Val Phe Asp Pro Tyr 
705                 710                 715                 720 


Leu Pro Arg Asn Leu Ser Val Val Glu Glu Glu Ala Asn Ala Phe Val 
                725                 730                 735     


Gly Gln Val Lys Ala Thr Asp Pro Asp Ala Gly Ile Asn Gly Gln Val 
            740                 745                 750         


His Tyr Ser Leu Gly Asn Phe Asn Asn Leu Phe Arg Ile Thr Ser Asn 
        755                 760                 765             


Gly Ser Ile Tyr Thr Ala Val Lys Leu Asn Arg Glu Val Arg Asp Tyr 
    770                 775                 780                 


Tyr Glu Leu Val Val Val Ala Thr Asp Gly Ala Val His Pro Arg His 
785                 790                 795                 800 


Ser Thr Leu Thr Leu Ala Ile Lys Val Leu Asp Ile Asp Asp Asn Ser 
                805                 810                 815     


Pro Val Phe Thr Asn Ser Thr Tyr Thr Val Leu Val Glu Glu Asn Leu 
            820                 825                 830         


Pro Ala Gly Thr Thr Ile Leu Gln Ile Glu Ala Lys Asp Val Asp Leu 
        835                 840                 845             


Gly Ala Asn Val Ser Tyr Arg Ile Arg Ser Pro Glu Val Lys His Phe 
    850                 855                 860                 


Phe Ala Leu His Pro Phe Thr Gly Glu Leu Ser Leu Leu Arg Ser Leu 
865                 870                 875                 880 


Asp Tyr Glu Ala Phe Pro Asp Gln Glu Ala Ser Ile Thr Phe Leu Val 
                885                 890                 895     


Glu Ala Phe Asp Ile Tyr Gly Thr Met Pro Pro Gly Ile Ala Thr Val 
            900                 905                 910         


Thr Val Ile Val Lys Asp Met Asn Asp Tyr Pro Pro Val Phe Ser Lys 
        915                 920                 925             


Arg Ile Tyr Lys Gly Met Val Ala Pro Asp Ala Val Lys Gly Thr Pro 
    930                 935                 940                 


Ile Thr Thr Val Tyr Ala Glu Asp Ala Asp Pro Pro Gly Leu Pro Ala 
945                 950                 955                 960 


Ser Arg Val Arg Tyr Arg Val Asp Asp Val Gln Phe Pro Tyr Pro Ala 
                965                 970                 975     


Ser Ile Phe Glu Val Glu Glu Asp Ser Gly Arg Val Ile Thr Arg Val 
            980                 985                 990         


Asn Leu Asn Glu Glu Pro Thr Thr  Ile Phe Lys Leu Val  Val Val Ala 
        995                 1000                 1005             


Phe Asp  Asp Gly Glu Pro Val  Met Ser Ser Ser Ala  Thr Val Lys 
    1010                 1015                 1020             


Ile Leu  Val Leu His Pro Gly  Glu Ile Pro Arg Phe  Thr Gln Glu 
    1025                 1030                 1035             


Glu Tyr  Arg Pro Pro Pro Val  Ser Glu Leu Ala Thr  Lys Gly Thr 
    1040                 1045                 1050             


Met Val  Gly Val Ile Ser Ala  Ala Ala Ile Asn Gln  Ser Ile Val 
    1055                 1060                 1065             


Tyr Ser  Ile Val Ser Gly Asn  Glu Glu Asp Thr Phe  Gly Ile Asn 
    1070                 1075                 1080             


Asn Ile  Thr Gly Val Ile Tyr  Val Asn Gly Pro Leu  Asp Tyr Glu 
    1085                 1090                 1095             


Thr Arg  Thr Ser Tyr Val Leu  Arg Val Gln Ala Asp  Ser Leu Glu 
    1100                 1105                 1110             


Val Val  Leu Ala Asn Leu Arg  Val Pro Ser Lys Ser  Asn Thr Ala 
    1115                 1120                 1125             


Lys Val  Tyr Ile Glu Ile Gln  Asp Glu Asn Asn His  Pro Pro Val 
    1130                 1135                 1140             


Phe Gln  Lys Lys Phe Tyr Ile  Gly Gly Val Ser Glu  Asp Ala Arg 
    1145                 1150                 1155             


Met Phe  Thr Ser Val Leu Arg  Val Lys Ala Thr Asp  Lys Asp Thr 
    1160                 1165                 1170             


Gly Asn  Tyr Ser Val Met Ala  Tyr Arg Leu Ile Ile  Pro Pro Ile 
    1175                 1180                 1185             


Lys Glu  Gly Lys Glu Gly Phe  Val Val Glu Thr Tyr  Thr Gly Leu 
    1190                 1195                 1200             


Ile Lys  Thr Ala Met Leu Phe  His Asn Met Arg Arg  Ser Tyr Phe 
    1205                 1210                 1215             


Lys Phe  Gln Val Ile Ala Thr  Asp Asp Tyr Gly Lys  Gly Leu Ser 
    1220                 1225                 1230             


Gly Lys  Ala Asp Val Leu Val  Ser Val Val Asn Gln  Leu Asp Met 
    1235                 1240                 1245             


Gln Val  Ile Val Ser Asn Val  Pro Pro Thr Leu Val  Glu Lys Lys 
    1250                 1255                 1260             


Ile Glu  Asp Leu Thr Glu Ile  Leu Asp Arg Tyr Val  Gln Glu Gln 
    1265                 1270                 1275             


Ile Pro  Gly Ala Lys Val Val  Val Glu Ser Ile Gly  Ala Arg Arg 
    1280                 1285                 1290             


His Gly  Asp Ala Phe Ser Leu  Glu Asp Tyr Thr Lys  Cys Asp Leu 
    1295                 1300                 1305             


Thr Val  Tyr Ala Ile Asp Pro  Gln Thr Asn Arg Ala  Ile Asp Arg 
    1310                 1315                 1320             


Asn Glu  Leu Phe Lys Phe Leu  Asp Gly Lys Leu Leu  Asp Ile Asn 
    1325                 1330                 1335             


Lys Asp  Phe Gln Pro Tyr Tyr  Gly Glu Gly Gly Arg  Ile Leu Glu 
    1340                 1345                 1350             


Ile Arg  Thr Pro Glu Ala Val  Thr Ser Ile Lys Lys  Arg Gly Glu 
    1355                 1360                 1365             


Ser Leu  Gly Tyr Thr Glu Gly  Ala Leu Leu Ala Leu  Ala Phe Ile 
    1370                 1375                 1380             


Ile Ile  Leu Cys Cys Ile Pro  Ala Ile Leu Val Val  Leu Val Ser 
    1385                 1390                 1395             


Tyr Arg  Gln Phe Lys Val Arg  Gln Ala Glu Cys Thr  Lys Thr Ala 
    1400                 1405                 1410             


Arg Ile  Gln Ala Ala Leu Pro  Ala Ala Lys Pro Ala  Val Pro Ala 
    1415                 1420                 1425             


Pro Ala  Pro Val Ala Ala Pro  Pro Pro Pro Pro Pro  Pro Pro Pro 
    1430                 1435                 1440             


Gly Ala  His Leu Tyr Glu Glu  Leu Gly Asp Ser Ser  Met His Lys 
    1445                 1450                 1455             


Tyr Glu  Met Pro Gln Tyr Gly  Ser Arg Arg Arg Leu  Leu Pro Pro 
    1460                 1465                 1470             


Ala Gly  Gln Glu Glu Tyr Gly  Glu Val Val Gly Glu  Ala Glu Glu 
    1475                 1480                 1485             


Glu Tyr  Glu Glu Glu Glu Trp  Ala Arg Lys Arg Met  Ile Lys Leu 
    1490                 1495                 1500             


Val Val  Asp Arg Glu Tyr Glu  Thr Ser Ser Thr Gly  Glu Asp Ser 
    1505                 1510                 1515             


Ala Pro  Glu Cys Gln Arg Asn  Arg Leu His His Pro  Ser Ile His 
    1520                 1525                 1530             


Ser Asn  Ile Asn Gly Asn Ile  Tyr Ile Ala Gln Asn  Gly Ser Val 
    1535                 1540                 1545             


Val Arg  Thr Arg Arg Ala Cys  Leu Thr Asp Asn Leu  Lys Val Ala 
    1550                 1555                 1560             


Ser Pro  Val Arg Leu Gly Gly  Pro Phe Lys Lys Leu  Asp Lys Leu 
    1565                 1570                 1575             


Ala Val  Thr His Glu Glu Asn  Val Pro Leu Asn Thr  Leu Ser Lys 
    1580                 1585                 1590             


Gly Pro  Phe Ser Thr Glu Lys  Met Asn Ala Arg Pro  Thr Leu Val 
    1595                 1600                 1605             


Thr Phe  Ala Pro Cys Pro Val  Gly Thr Asp Asn Thr  Ala Val Lys 
    1610                 1615                 1620             


Pro Leu  Arg Asn Arg Leu Lys  Ser Thr Val Glu Gln  Glu Ser Met 
    1625                 1630                 1635             


Ile Asp  Ser Lys Asn Ile Lys  Glu Ala Leu Glu Phe  His Ser Asp 
    1640                 1645                 1650             


His Thr  Gln Ser Asp Asp Glu  Glu Leu Trp Met Gly  Pro Trp Asn 
    1655                 1660                 1665             


Asn Leu  His Ile Pro Met Thr  Lys Leu 
    1670                 1675         


<210>  10060
<211>  1957
<212>  PRT
<213>  Homo Sapiens

<400>  10060

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Cys 
            20                  25                  30          


Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile Val Ala Ile Asp Glu 
        35                  40                  45              


Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn Met Leu Ile Lys Gly 
    50                  55                  60                  


Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu Ser Leu Lys Asp Asn 
65                  70                  75                  80  


Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys Gln Met Leu Phe Leu 
                85                  90                  95      


Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro Pro Met Asn Ile His 
            100                 105                 110         


Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys Lys Val Gly Thr Ile 
        115                 120                 125             


Ile Tyr His Glu Val Arg Ile Val Val Arg Asp Arg Asn Asp Asn Ser 
    130                 135                 140                 


Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr Val Asn Glu Leu Thr 
145                 150                 155                 160 


Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser Gly Asp Asn Gly Ala 
                165                 170                 175     


Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile Glu Tyr Val Ile Gln 
            180                 185                 190         


Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr Phe Glu Ile Pro Leu 
        195                 200                 205             


Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg Leu Asn Tyr Glu Asp 
    210                 215                 220                 


Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn Asp Arg Ala Gln Asn 
225                 230                 235                 240 


Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu Thr Val Asp Val Leu 
                245                 250                 255     


Asp Gly Asp Asp Leu Gly Pro Met Phe Leu Pro Cys Val Leu Val Pro 
            260                 265                 270         


Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln Ala Ala Ile Pro Glu 
        275                 280                 285             


Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile Val Thr Pro Pro Ile 
    290                 295                 300                 


Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro Pro Ser Asp Arg Pro 
305                 310                 315                 320 


Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro Glu Asp Tyr Pro Arg 
                325                 330                 335     


Phe Phe His Met His Pro Arg Thr Ala Glu Leu Ser Leu Leu Glu Pro 
            340                 345                 350         


Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu Val Ile Lys Ala Glu 
        355                 360                 365             


Gln Asp Asn Gly His Pro Leu Pro Ala Phe Ala Gly Leu His Ile Glu 
    370                 375                 380                 


Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe Thr Met Pro Ser Tyr 
385                 390                 395                 400 


Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly Ala Thr Ile Ser Asp 
                405                 410                 415     


Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val Ala Leu Asp Lys Asp 
            420                 425                 430         


Ile Glu Asp Thr Lys Asp Pro Glu Leu His Leu Phe Leu Asn Asp Tyr 
        435                 440                 445             


Thr Ser Val Phe Thr Val Thr Gln Thr Gly Ile Thr Arg Tyr Leu Thr 
    450                 455                 460                 


Leu Leu Gln Pro Val Asp Arg Glu Glu Gln Gln Thr Tyr Thr Phe Ser 
465                 470                 475                 480 


Ile Thr Ala Phe Asp Gly Val Gln Glu Ser Glu Pro Val Ile Val Asn 
                485                 490                 495     


Ile Gln Val Met Asp Ala Asn Asp Asn Thr Pro Thr Phe Pro Glu Ile 
            500                 505                 510         


Ser Tyr Asp Val Tyr Val Tyr Thr Asp Met Arg Pro Gly Asp Ser Val 
        515                 520                 525             


Ile Gln Leu Thr Ala Val Asp Ala Asp Glu Gly Ser Asn Gly Glu Ile 
    530                 535                 540                 


Thr Tyr Glu Ile Leu Val Gly Ala Gln Gly Asp Phe Ile Ile Asn Lys 
545                 550                 555                 560 


Thr Thr Gly Leu Ile Thr Ile Ala Pro Gly Val Glu Met Ile Val Gly 
                565                 570                 575     


Arg Thr Tyr Ala Leu Thr Val Gln Ala Ala Asp Asn Ala Pro Pro Ala 
            580                 585                 590         


Glu Arg Arg Asn Ser Ile Cys Thr Val Tyr Ile Glu Val Leu Pro Pro 
        595                 600                 605             


Asn Asn Gln Ser Pro Pro Arg Phe Pro Gln Leu Met Tyr Ser Leu Glu 
    610                 615                 620                 


Ile Ser Glu Ala Met Arg Val Gly Ala Val Leu Leu Asn Leu Gln Ala 
625                 630                 635                 640 


Thr Asp Arg Glu Gly Asp Ser Ile Thr Tyr Ala Ile Glu Asn Gly Asp 
                645                 650                 655     


Pro Gln Arg Val Phe Asn Leu Ser Glu Thr Thr Gly Ile Leu Thr Leu 
            660                 665                 670         


Gly Lys Ala Leu Asp Arg Glu Ser Thr Asp Arg Tyr Ile Leu Ile Ile 
        675                 680                 685             


Thr Ala Ser Asp Gly Arg Pro Asp Gly Thr Ser Thr Ala Thr Val Asn 
    690                 695                 700                 


Ile Val Val Thr Asp Val Asn Asp Asn Ala Pro Val Phe Asp Pro Tyr 
705                 710                 715                 720 


Leu Pro Arg Asn Leu Ser Val Val Glu Glu Glu Ala Asn Ala Phe Val 
                725                 730                 735     


Gly Gln Val Lys Ala Thr Asp Pro Asp Ala Gly Ile Asn Gly Gln Val 
            740                 745                 750         


His Tyr Ser Leu Gly Asn Phe Asn Asn Leu Phe Arg Ile Thr Ser Asn 
        755                 760                 765             


Gly Ser Ile Tyr Thr Ala Val Lys Leu Asn Arg Glu Val Arg Asp Tyr 
    770                 775                 780                 


Tyr Glu Leu Val Val Val Ala Thr Asp Gly Ala Val His Pro Arg His 
785                 790                 795                 800 


Ser Thr Leu Thr Leu Ala Ile Lys Val Leu Asp Ile Asp Asp Asn Ser 
                805                 810                 815     


Pro Val Phe Thr Asn Ser Thr Tyr Thr Val Leu Val Glu Glu Asn Leu 
            820                 825                 830         


Pro Ala Gly Thr Thr Ile Leu Gln Ile Glu Ala Lys Asp Val Asp Leu 
        835                 840                 845             


Gly Ala Asn Val Ser Tyr Arg Ile Arg Ser Pro Glu Val Lys His Phe 
    850                 855                 860                 


Phe Ala Leu His Pro Phe Thr Gly Glu Leu Ser Leu Leu Arg Ser Leu 
865                 870                 875                 880 


Asp Tyr Glu Ala Phe Pro Asp Gln Glu Ala Ser Ile Thr Phe Leu Val 
                885                 890                 895     


Glu Ala Phe Asp Ile Tyr Gly Thr Met Pro Pro Gly Ile Ala Thr Val 
            900                 905                 910         


Thr Val Ile Val Lys Asp Met Asn Asp Tyr Pro Pro Val Phe Ser Lys 
        915                 920                 925             


Arg Ile Tyr Lys Gly Met Val Ala Pro Asp Ala Val Lys Gly Thr Pro 
    930                 935                 940                 


Ile Thr Thr Val Tyr Ala Glu Asp Ala Asp Pro Pro Gly Leu Pro Ala 
945                 950                 955                 960 


Ser Arg Val Arg Tyr Arg Val Asp Asp Val Gln Phe Pro Tyr Pro Ala 
                965                 970                 975     


Ser Ile Phe Glu Val Glu Glu Asp Ser Gly Arg Val Ile Thr Arg Val 
            980                 985                 990         


Asn Leu Asn Glu Glu Pro Thr Thr  Ile Phe Lys Leu Val  Val Val Ala 
        995                 1000                 1005             


Phe Asp  Asp Gly Glu Pro Val  Met Ser Ser Ser Ala  Thr Val Lys 
    1010                 1015                 1020             


Ile Leu  Val Leu His Pro Gly  Glu Ile Pro Arg Phe  Thr Gln Glu 
    1025                 1030                 1035             


Glu Tyr  Arg Pro Pro Pro Val  Ser Glu Leu Ala Thr  Lys Gly Thr 
    1040                 1045                 1050             


Met Val  Gly Val Ile Ser Ala  Ala Ala Ile Asn Gln  Ser Ile Val 
    1055                 1060                 1065             


Tyr Ser  Ile Val Ser Gly Asn  Glu Glu Asp Thr Phe  Gly Ile Asn 
    1070                 1075                 1080             


Asn Ile  Thr Gly Val Ile Tyr  Val Asn Gly Pro Leu  Asp Tyr Glu 
    1085                 1090                 1095             


Thr Arg  Thr Ser Tyr Val Leu  Arg Val Gln Ala Asp  Ser Leu Glu 
    1100                 1105                 1110             


Val Val  Leu Ala Asn Leu Arg  Val Pro Ser Lys Ser  Asn Thr Ala 
    1115                 1120                 1125             


Lys Val  Tyr Ile Glu Ile Gln  Asp Glu Asn Asn His  Pro Pro Val 
    1130                 1135                 1140             


Phe Gln  Lys Lys Phe Tyr Ile  Gly Gly Val Ser Glu  Asp Ala Arg 
    1145                 1150                 1155             


Met Phe  Thr Ser Val Leu Arg  Val Lys Ala Thr Asp  Lys Asp Thr 
    1160                 1165                 1170             


Gly Asn  Tyr Ser Val Met Ala  Tyr Arg Leu Ile Ile  Pro Pro Ile 
    1175                 1180                 1185             


Lys Glu  Gly Lys Glu Gly Phe  Val Val Glu Thr Tyr  Thr Gly Leu 
    1190                 1195                 1200             


Ile Lys  Thr Ala Met Leu Phe  His Asn Met Arg Arg  Ser Tyr Phe 
    1205                 1210                 1215             


Lys Phe  Gln Val Ile Ala Thr  Asp Asp Tyr Gly Lys  Gly Leu Ser 
    1220                 1225                 1230             


Gly Lys  Ala Asp Val Leu Val  Ser Val Val Asn Gln  Leu Asp Met 
    1235                 1240                 1245             


Gln Val  Ile Val Ser Asn Val  Pro Pro Thr Leu Val  Glu Lys Lys 
    1250                 1255                 1260             


Ile Glu  Asp Leu Thr Glu Ile  Leu Asp Arg Tyr Val  Gln Glu Gln 
    1265                 1270                 1275             


Ile Pro  Gly Ala Lys Val Val  Val Glu Ser Ile Gly  Ala Arg Arg 
    1280                 1285                 1290             


His Gly  Asp Ala Phe Ser Leu  Glu Asp Tyr Thr Lys  Cys Asp Leu 
    1295                 1300                 1305             


Thr Val  Tyr Ala Ile Asp Pro  Gln Thr Asn Arg Ala  Ile Asp Arg 
    1310                 1315                 1320             


Asn Glu  Leu Phe Lys Phe Leu  Asp Gly Lys Leu Leu  Asp Ile Asn 
    1325                 1330                 1335             


Lys Asp  Phe Gln Pro Tyr Tyr  Gly Glu Gly Gly Arg  Ile Leu Glu 
    1340                 1345                 1350             


Ile Arg  Thr Pro Glu Ala Val  Thr Ser Ile Lys Lys  Arg Gly Glu 
    1355                 1360                 1365             


Ser Leu  Gly Tyr Thr Glu Gly  Ala Leu Leu Ala Leu  Ala Phe Ile 
    1370                 1375                 1380             


Ile Ile  Leu Cys Cys Ile Pro  Ala Ile Leu Val Val  Leu Val Ser 
    1385                 1390                 1395             


Tyr Arg  Gln Phe Lys Val Arg  Gln Ala Glu Cys Thr  Lys Thr Ala 
    1400                 1405                 1410             


Arg Ile  Gln Ala Ala Leu Pro  Ala Ala Lys Pro Ala  Val Pro Ala 
    1415                 1420                 1425             


Pro Ala  Pro Val Ala Ala Pro  Pro Pro Pro Pro Pro  Pro Pro Pro 
    1430                 1435                 1440             


Gly Ala  His Leu Tyr Glu Glu  Leu Gly Asp Ser Ser  Met His Asn 
    1445                 1450                 1455             


Leu Phe  Leu Leu Tyr His Phe  Gln Gln Ser Arg Gly  Asn Asn Ser 
    1460                 1465                 1470             


Val Ser  Glu Asp Arg Lys His  Gln Gln Val Val Met  Pro Phe Ser 
    1475                 1480                 1485             


Ser Asn  Thr Ile Glu Ala His  Lys Ser Ala His Val  Asp Gly Ser 
    1490                 1495                 1500             


Leu Lys  Ser Asn Lys Leu Lys  Ser Ala Arg Lys Phe  Thr Phe Leu 
    1505                 1510                 1515             


Ser Asp  Glu Asp Asp Leu Ser  Ala His Asn Pro Leu  Tyr Lys Glu 
    1520                 1525                 1530             


Asn Ile  Ser Gln Val Ser Thr  Asn Ser Asp Ile Ser  Gln Arg Thr 
    1535                 1540                 1545             


Asp Phe  Val Asp Pro Phe Ser  Pro Lys Ile Gln Ala  Lys Ser Lys 
    1550                 1555                 1560             


Ser Leu  Arg Gly Pro Arg Glu  Lys Ile Gln Arg Leu  Trp Ser Gln 
    1565                 1570                 1575             


Ser Val  Ser Leu Pro Arg Arg  Leu Met Arg Lys Val  Pro Asn Arg 
    1580                 1585                 1590             


Pro Glu  Ile Ile Asp Leu Gln  Gln Trp Gln Gly Thr  Arg Gln Lys 
    1595                 1600                 1605             


Ala Glu  Asn Glu Asn Thr Gly  Ile Cys Thr Asn Lys  Arg Gly Ser 
    1610                 1615                 1620             


Ser Asn  Pro Leu Leu Thr Thr  Glu Glu Ala Asn Leu  Thr Glu Lys 
    1625                 1630                 1635             


Glu Glu  Ile Arg Gln Gly Glu  Thr Leu Met Ile Glu  Gly Thr Glu 
    1640                 1645                 1650             


Gln Leu  Lys Ser Leu Ser Ser  Asp Ser Ser Phe Cys  Phe Pro Arg 
    1655                 1660                 1665             


Pro His  Phe Ser Phe Ser Thr  Leu Pro Thr Val Ser  Arg Thr Val 
    1670                 1675                 1680             


Glu Leu  Lys Ser Glu Pro Asn  Val Ile Ser Ser Pro  Ala Glu Cys 
    1685                 1690                 1695             


Ser Leu  Glu Leu Ser Pro Ser  Arg Pro Cys Val Leu  His Ser Ser 
    1700                 1705                 1710             


Leu Ser  Arg Arg Glu Thr Pro  Ile Cys Met Leu Pro  Ile Glu Thr 
    1715                 1720                 1725             


Glu Arg  Asn Ile Phe Glu Asn  Phe Ala His Pro Pro  Asn Ile Ser 
    1730                 1735                 1740             


Pro Ser  Ala Cys Pro Leu Pro  Pro Pro Pro Pro Ile  Ser Pro Pro 
    1745                 1750                 1755             


Ser Pro  Pro Pro Ala Pro Ala  Pro Leu Ala Pro Pro  Pro Asp Ile 
    1760                 1765                 1770             


Ser Pro  Phe Ser Leu Phe Cys  Pro Pro Pro Ser Pro  Pro Ser Ile 
    1775                 1780                 1785             


Pro Leu  Pro Leu Pro Pro Pro  Thr Phe Phe Pro Leu  Ser Val Ser 
    1790                 1795                 1800             


Thr Ser  Gly Pro Pro Thr Pro  Pro Leu Leu Pro Pro  Phe Pro Thr 
    1805                 1810                 1815             


Pro Leu  Pro Pro Pro Pro Pro  Ser Ile Pro Cys Pro  Pro Pro Pro 
    1820                 1825                 1830             


Ser Ala  Ser Phe Leu Ser Thr  Glu Cys Val Cys Ile  Thr Gly Val 
    1835                 1840                 1845             


Lys Cys  Thr Thr Asn Leu Met  Pro Ala Glu Lys Ile  Lys Ser Ser 
    1850                 1855                 1860             


Met Thr  Gln Leu Ser Thr Thr  Thr Val Cys Lys Thr  Asp Pro Gln 
    1865                 1870                 1875             


Arg Glu  Pro Lys Gly Ile Leu  Arg His Val Lys Asn  Leu Ala Glu 
    1880                 1885                 1890             


Leu Glu  Lys Ser Val Ala Asn  Met Tyr Ser Gln Ile  Glu Lys Asn 
    1895                 1900                 1905             


Tyr Leu  Arg Thr Asn Val Ser  Glu Leu Gln Thr Met  Cys Pro Ser 
    1910                 1915                 1920             


Glu Val  Thr Asn Met Glu Ile  Thr Ser Glu Gln Asn  Lys Gly Ser 
    1925                 1930                 1935             


Leu Asn  Asn Ile Val Glu Gly  Thr Glu Lys Gln Ser  His Ser Gln 
    1940                 1945                 1950             


Ser Thr  Ser Leu 
    1955         


<210>  10061
<211>  1540
<212>  PRT
<213>  Homo Sapiens

<400>  10061

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Cys 
            20                  25                  30          


Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile Val Ala Ile Asp Glu 
        35                  40                  45              


Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn Met Leu Ile Lys Gly 
    50                  55                  60                  


Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu Ser Leu Lys Asp Asn 
65                  70                  75                  80  


Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys Gln Met Leu Phe Leu 
                85                  90                  95      


Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro Pro Met Asn Ile His 
            100                 105                 110         


Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys Lys Val Gly Thr Ile 
        115                 120                 125             


Ile Tyr His Glu Val Arg Ile Val Val Arg Asp Arg Asn Asp Asn Ser 
    130                 135                 140                 


Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr Val Asn Glu Leu Thr 
145                 150                 155                 160 


Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser Gly Asp Asn Gly Ala 
                165                 170                 175     


Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile Glu Tyr Val Ile Gln 
            180                 185                 190         


Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr Phe Glu Ile Pro Leu 
        195                 200                 205             


Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg Leu Asn Tyr Glu Asp 
    210                 215                 220                 


Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn Asp Arg Ala Gln Asn 
225                 230                 235                 240 


Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu Thr Val Asp Val Leu 
                245                 250                 255     


Asp Gly Asp Asp Leu Gly Pro Met Phe Leu Pro Cys Val Leu Val Pro 
            260                 265                 270         


Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln Ala Ala Ile Pro Glu 
        275                 280                 285             


Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile Val Thr Pro Pro Ile 
    290                 295                 300                 


Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro Pro Ser Asp Arg Pro 
305                 310                 315                 320 


Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro Glu Asp Tyr Pro Arg 
                325                 330                 335     


Phe Phe His Met His Pro Arg Thr Ala Glu Leu Ser Leu Leu Glu Pro 
            340                 345                 350         


Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu Val Ile Lys Ala Glu 
        355                 360                 365             


Gln Asp Asn Gly His Pro Leu Pro Ala Phe Ala Gly Leu His Ile Glu 
    370                 375                 380                 


Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe Thr Met Pro Ser Tyr 
385                 390                 395                 400 


Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly Ala Thr Ile Ser Asp 
                405                 410                 415     


Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val Ala Leu Asp Lys Asp 
            420                 425                 430         


Ile Glu Asp Thr Lys Asp Pro Glu Leu His Leu Phe Leu Asn Asp Tyr 
        435                 440                 445             


Thr Ser Val Phe Thr Val Thr Gln Thr Gly Ile Thr Arg Tyr Leu Thr 
    450                 455                 460                 


Leu Leu Gln Pro Val Asp Arg Glu Glu Gln Gln Thr Tyr Thr Phe Ser 
465                 470                 475                 480 


Ile Thr Ala Phe Asp Gly Val Gln Glu Ser Glu Pro Val Ile Val Asn 
                485                 490                 495     


Ile Gln Val Met Asp Ala Asn Asp Asn Thr Pro Thr Phe Pro Glu Ile 
            500                 505                 510         


Ser Tyr Asp Val Tyr Val Tyr Thr Asp Met Arg Pro Gly Asp Ser Val 
        515                 520                 525             


Ile Gln Leu Thr Ala Val Asp Ala Asp Glu Gly Ser Asn Gly Glu Ile 
    530                 535                 540                 


Thr Tyr Glu Ile Leu Val Gly Ala Gln Gly Asp Phe Ile Ile Asn Lys 
545                 550                 555                 560 


Thr Thr Gly Leu Ile Thr Ile Ala Pro Gly Val Glu Met Ile Val Gly 
                565                 570                 575     


Arg Thr Tyr Ala Leu Thr Val Gln Ala Ala Asp Asn Ala Pro Pro Ala 
            580                 585                 590         


Glu Arg Arg Asn Ser Ile Cys Thr Val Tyr Ile Glu Val Leu Pro Pro 
        595                 600                 605             


Asn Asn Gln Ser Pro Pro Arg Phe Pro Gln Leu Met Tyr Ser Leu Glu 
    610                 615                 620                 


Ile Ser Glu Ala Met Arg Val Gly Ala Val Leu Leu Asn Leu Gln Ala 
625                 630                 635                 640 


Thr Asp Arg Glu Gly Asp Ser Ile Thr Tyr Ala Ile Glu Asn Gly Asp 
                645                 650                 655     


Pro Gln Arg Val Phe Asn Leu Ser Glu Thr Thr Gly Ile Leu Thr Leu 
            660                 665                 670         


Gly Lys Ala Leu Asp Arg Glu Ser Thr Asp Arg Tyr Ile Leu Ile Ile 
        675                 680                 685             


Thr Ala Ser Asp Gly Arg Pro Asp Gly Thr Ser Thr Ala Thr Val Asn 
    690                 695                 700                 


Ile Val Val Thr Asp Val Asn Asp Asn Ala Pro Val Phe Asp Pro Tyr 
705                 710                 715                 720 


Leu Pro Arg Asn Leu Ser Val Val Glu Glu Glu Ala Asn Ala Phe Val 
                725                 730                 735     


Gly Gln Val Lys Ala Thr Asp Pro Asp Ala Gly Ile Asn Gly Gln Val 
            740                 745                 750         


His Tyr Ser Leu Gly Asn Phe Asn Asn Leu Phe Arg Ile Thr Ser Asn 
        755                 760                 765             


Gly Ser Ile Tyr Thr Ala Val Lys Leu Asn Arg Glu Val Arg Asp Tyr 
    770                 775                 780                 


Tyr Glu Leu Val Val Val Ala Thr Asp Gly Ala Val His Pro Arg His 
785                 790                 795                 800 


Ser Thr Leu Thr Leu Ala Ile Lys Val Leu Asp Ile Asp Asp Asn Ser 
                805                 810                 815     


Pro Val Phe Thr Asn Ser Thr Tyr Thr Val Leu Val Glu Glu Asn Leu 
            820                 825                 830         


Pro Ala Gly Thr Thr Ile Leu Gln Ile Glu Ala Lys Asp Val Asp Leu 
        835                 840                 845             


Gly Ala Asn Val Ser Tyr Arg Ile Arg Ser Pro Glu Val Lys His Phe 
    850                 855                 860                 


Phe Ala Leu His Pro Phe Thr Gly Glu Leu Ser Leu Leu Arg Ser Leu 
865                 870                 875                 880 


Asp Tyr Glu Ala Phe Pro Asp Gln Glu Ala Ser Ile Thr Phe Leu Val 
                885                 890                 895     


Glu Ala Phe Asp Ile Tyr Gly Thr Met Pro Pro Gly Ile Ala Thr Val 
            900                 905                 910         


Thr Val Ile Val Lys Asp Met Asn Asp Tyr Pro Pro Val Phe Ser Lys 
        915                 920                 925             


Arg Ile Tyr Lys Gly Met Val Ala Pro Asp Ala Val Lys Gly Thr Pro 
    930                 935                 940                 


Ile Thr Thr Val Tyr Ala Glu Asp Ala Asp Pro Pro Gly Leu Pro Ala 
945                 950                 955                 960 


Ser Arg Val Arg Tyr Arg Val Asp Asp Val Gln Phe Pro Tyr Pro Ala 
                965                 970                 975     


Ser Ile Phe Glu Val Glu Glu Asp Ser Gly Arg Val Ile Thr Arg Val 
            980                 985                 990         


Asn Leu Asn Glu Glu Pro Thr Thr  Ile Phe Lys Leu Val  Val Val Ala 
        995                 1000                 1005             


Phe Asp  Asp Gly Glu Pro Val  Met Ser Ser Ser Ala  Thr Val Lys 
    1010                 1015                 1020             


Ile Leu  Val Leu His Pro Gly  Glu Ile Pro Arg Phe  Thr Gln Glu 
    1025                 1030                 1035             


Glu Tyr  Arg Pro Pro Pro Val  Ser Glu Leu Ala Thr  Lys Gly Thr 
    1040                 1045                 1050             


Met Val  Gly Val Ile Ser Ala  Ala Ala Ile Asn Gln  Ser Ile Val 
    1055                 1060                 1065             


Tyr Ser  Ile Val Ser Gly Asn  Glu Glu Asp Thr Phe  Gly Ile Asn 
    1070                 1075                 1080             


Asn Ile  Thr Gly Val Ile Tyr  Val Asn Gly Pro Leu  Asp Tyr Glu 
    1085                 1090                 1095             


Thr Arg  Thr Ser Tyr Val Leu  Arg Val Gln Ala Asp  Ser Leu Glu 
    1100                 1105                 1110             


Val Val  Leu Ala Asn Leu Arg  Val Pro Ser Lys Ser  Asn Thr Ala 
    1115                 1120                 1125             


Lys Val  Tyr Ile Glu Ile Gln  Asp Glu Asn Asn His  Pro Pro Val 
    1130                 1135                 1140             


Phe Gln  Lys Lys Phe Tyr Ile  Gly Gly Val Ser Glu  Asp Ala Arg 
    1145                 1150                 1155             


Met Phe  Thr Ser Val Leu Arg  Val Lys Ala Thr Asp  Lys Asp Thr 
    1160                 1165                 1170             


Gly Asn  Tyr Ser Val Met Ala  Tyr Arg Leu Ile Ile  Pro Pro Ile 
    1175                 1180                 1185             


Lys Glu  Gly Lys Glu Gly Phe  Val Val Glu Thr Tyr  Thr Gly Leu 
    1190                 1195                 1200             


Ile Lys  Thr Ala Met Leu Phe  His Asn Met Arg Arg  Ser Tyr Phe 
    1205                 1210                 1215             


Lys Phe  Gln Val Ile Ala Thr  Asp Asp Tyr Gly Lys  Gly Leu Ser 
    1220                 1225                 1230             


Gly Lys  Ala Asp Val Leu Val  Ser Val Val Asn Gln  Leu Asp Met 
    1235                 1240                 1245             


Gln Val  Ile Val Ser Asn Val  Pro Pro Thr Leu Val  Glu Lys Lys 
    1250                 1255                 1260             


Ile Glu  Asp Leu Thr Glu Ile  Leu Asp Arg Tyr Val  Gln Glu Gln 
    1265                 1270                 1275             


Ile Pro  Gly Ala Lys Val Val  Val Glu Ser Ile Gly  Ala Arg Arg 
    1280                 1285                 1290             


His Gly  Asp Ala Phe Ser Leu  Glu Asp Tyr Thr Lys  Cys Asp Leu 
    1295                 1300                 1305             


Thr Val  Tyr Ala Ile Asp Pro  Gln Thr Asn Arg Ala  Ile Asp Arg 
    1310                 1315                 1320             


Asn Glu  Leu Phe Lys Phe Leu  Asp Gly Lys Leu Leu  Asp Ile Asn 
    1325                 1330                 1335             


Lys Asp  Phe Gln Pro Tyr Tyr  Gly Glu Gly Gly Arg  Ile Leu Glu 
    1340                 1345                 1350             


Ile Arg  Thr Pro Glu Ala Val  Thr Ser Ile Lys Lys  Arg Gly Glu 
    1355                 1360                 1365             


Ser Leu  Gly Tyr Thr Glu Gly  Ala Leu Leu Ala Leu  Ala Phe Ile 
    1370                 1375                 1380             


Ile Ile  Leu Cys Cys Ile Pro  Ala Ile Leu Val Val  Leu Val Ser 
    1385                 1390                 1395             


Tyr Arg  Gln Val Phe Lys Gly  Arg Gln Ala Glu Cys  Thr Lys Thr 
    1400                 1405                 1410             


Ala Arg  Ile Gln Ala Ala Leu  Pro Ala Ala Lys Pro  Ala Val Pro 
    1415                 1420                 1425             


Ala Pro  Ala Pro Val Ala Ala  Pro Pro Pro Pro Pro  Pro Pro Pro 
    1430                 1435                 1440             


Pro Gly  Ala His Leu Tyr Glu  Glu Leu Gly Asp Ser  Ser Met Asn 
    1445                 1450                 1455             


Arg Asn  Tyr Pro Trp Ser Leu  Glu Leu Ile Leu Ala  Arg Asn Met 
    1460                 1465                 1470             


Asp Lys  Ile Ile Thr Val Met  Ser Met Gly Met Lys  Cys Leu Asn 
    1475                 1480                 1485             


Met Gly  Val Ala Val Asp Cys  Tyr His Gln Leu Asp  Arg Arg Asn 
    1490                 1495                 1500             


Met Val  Arg Trp Leu Val Lys  Leu Arg Lys Asn Met  Arg Arg Lys 
    1505                 1510                 1515             


Arg Lys  Ser Gln Arg Lys Leu  Lys Asn Gln Arg Leu  Lys Leu Glu 
    1520                 1525                 1530             


Ser Leu  Val Arg Arg Lys Lys  
    1535                 1540 


<210>  10062
<211>  654
<212>  PRT
<213>  Homo Sapiens

<400>  10062

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Cys 
            20                  25                  30          


Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile Val Ala Ile Asp Glu 
        35                  40                  45              


Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn Met Leu Ile Lys Gly 
    50                  55                  60                  


Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu Ser Leu Lys Asp Asn 
65                  70                  75                  80  


Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys Gln Met Leu Phe Leu 
                85                  90                  95      


Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro Pro Met Asn Ile His 
            100                 105                 110         


Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys Lys Val Gly Thr Ile 
        115                 120                 125             


Ile Tyr His Glu Val Arg Ile Val Val Arg Asp Arg Asn Asp Asn Ser 
    130                 135                 140                 


Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr Val Asn Glu Leu Thr 
145                 150                 155                 160 


Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser Gly Asp Asn Gly Ala 
                165                 170                 175     


Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile Glu Tyr Val Ile Gln 
            180                 185                 190         


Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr Phe Glu Ile Pro Leu 
        195                 200                 205             


Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg Leu Asn Tyr Glu Asp 
    210                 215                 220                 


Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn Asp Arg Ala Gln Asn 
225                 230                 235                 240 


Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu Thr Val Asp Val Leu 
                245                 250                 255     


Asp Gly Asp Asp Leu Gly Pro Met Phe Leu Pro Cys Val Leu Val Pro 
            260                 265                 270         


Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln Ala Ala Ile Pro Glu 
        275                 280                 285             


Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile Val Thr Pro Pro Ile 
    290                 295                 300                 


Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro Pro Ser Asp Arg Pro 
305                 310                 315                 320 


Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro Glu Asp Tyr Pro Arg 
                325                 330                 335     


Phe Phe His Met His Pro Arg Thr Ala Glu Leu Ser Leu Leu Glu Pro 
            340                 345                 350         


Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu Val Ile Lys Ala Glu 
        355                 360                 365             


Gln Asp Asn Gly His Pro Leu Pro Ala Phe Ala Gly Leu His Ile Glu 
    370                 375                 380                 


Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe Thr Met Pro Ser Tyr 
385                 390                 395                 400 


Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly Ala Thr Ile Ser Asp 
                405                 410                 415     


Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val Ala Leu Asp Lys Asp 
            420                 425                 430         


Ile Glu Asp Thr Lys Asp Pro Glu Leu His Leu Phe Leu Asn Asp Tyr 
        435                 440                 445             


Thr Ser Val Phe Thr Val Thr Gln Thr Gly Ile Thr Arg Tyr Leu Thr 
    450                 455                 460                 


Leu Leu Gln Pro Val Asp Arg Glu Glu Gln Gln Thr Tyr Thr Phe Ser 
465                 470                 475                 480 


Ile Thr Ala Phe Asp Gly Val Gln Glu Ser Glu Pro Val Ile Val Asn 
                485                 490                 495     


Ile Gln Val Met Asp Ala Asn Asp Asn Thr Pro Thr Phe Pro Glu Ile 
            500                 505                 510         


Ser Tyr Asp Val Tyr Val Tyr Thr Asp Met Arg Pro Gly Asp Ser Val 
        515                 520                 525             


Ile Gln Leu Thr Ala Val Asp Ala Asp Glu Gly Ser Asn Gly Glu Ile 
    530                 535                 540                 


Thr Tyr Glu Ile Leu Val Gly Ala Gln Gly Asp Phe Ile Ile Asn Lys 
545                 550                 555                 560 


Thr Thr Gly Leu Ile Thr Ile Ala Pro Gly Val Glu Met Ile Val Gly 
                565                 570                 575     


Arg Thr Tyr Ala Leu Thr Val Gln Ala Ala Asp Asn Ala Pro Pro Ala 
            580                 585                 590         


Glu Arg Arg Asn Ser Ile Cys Thr Val Tyr Ile Glu Val Leu Pro Pro 
        595                 600                 605             


Asn Asn Gln Ser Pro Pro Arg Phe Pro Gln Leu Met Tyr Ser Leu Glu 
    610                 615                 620                 


Ile Ser Glu Ala Met Arg Val Gly Ala Val Leu Leu Asn Leu Gln His 
625                 630                 635                 640 


Gly Asp Ser Asn Leu Arg Glu Ser Thr Gly Gln Gly Lys His 
                645                 650                 


<210>  10063
<211>  1783
<212>  PRT
<213>  Homo Sapiens

<400>  10063

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Cys 
            20                  25                  30          


Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile Val Ala Ile Asp Glu 
        35                  40                  45              


Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn Met Leu Ile Lys Gly 
    50                  55                  60                  


Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu Ser Leu Lys Asp Asn 
65                  70                  75                  80  


Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys Gln Met Leu Phe Leu 
                85                  90                  95      


Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro Pro Met Asn Ile His 
            100                 105                 110         


Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys Lys Val Gly Thr Ile 
        115                 120                 125             


Ile Tyr His Glu Val Arg Ile Val Val Arg Asp Arg Asn Asp Asn Ser 
    130                 135                 140                 


Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr Val Asn Glu Leu Thr 
145                 150                 155                 160 


Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser Gly Asp Asn Gly Ala 
                165                 170                 175     


Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile Glu Tyr Val Ile Gln 
            180                 185                 190         


Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr Phe Glu Ile Pro Leu 
        195                 200                 205             


Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg Leu Asn Tyr Glu Asp 
    210                 215                 220                 


Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn Asp Arg Ala Gln Asn 
225                 230                 235                 240 


Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu Thr Val Asp Val Leu 
                245                 250                 255     


Asp Gly Asp Asp Leu Gly Pro Met Phe Leu Pro Cys Val Leu Val Pro 
            260                 265                 270         


Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln Ala Ala Ile Pro Glu 
        275                 280                 285             


Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile Val Thr Pro Pro Ile 
    290                 295                 300                 


Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro Pro Ser Asp Arg Pro 
305                 310                 315                 320 


Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro Glu Asp Tyr Pro Arg 
                325                 330                 335     


Phe Phe His Met His Pro Arg Thr Ala Glu Leu Ser Leu Leu Glu Pro 
            340                 345                 350         


Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu Val Ile Lys Ala Glu 
        355                 360                 365             


Gln Asp Asn Gly His Pro Leu Pro Ala Phe Ala Gly Leu His Ile Glu 
    370                 375                 380                 


Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe Thr Met Pro Ser Tyr 
385                 390                 395                 400 


Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly Ala Thr Ile Ser Asp 
                405                 410                 415     


Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val Ala Leu Asp Lys Asp 
            420                 425                 430         


Ile Glu Asp Val Pro Pro Ser Gly Val Pro Thr Lys Asp Pro Glu Leu 
        435                 440                 445             


His Leu Phe Leu Asn Asp Tyr Thr Ser Val Phe Thr Val Thr Gln Thr 
    450                 455                 460                 


Gly Ile Thr Arg Tyr Leu Thr Leu Leu Gln Pro Val Asp Arg Glu Glu 
465                 470                 475                 480 


Gln Gln Thr Tyr Thr Phe Ser Ile Thr Ala Phe Asp Gly Val Gln Glu 
                485                 490                 495     


Ser Glu Pro Val Ile Val Asn Ile Gln Val Met Asp Ala Asn Asp Asn 
            500                 505                 510         


Thr Pro Thr Phe Pro Glu Ile Ser Tyr Asp Val Tyr Val Tyr Thr Asp 
        515                 520                 525             


Met Arg Pro Gly Asp Ser Val Ile Gln Leu Thr Ala Val Asp Ala Asp 
    530                 535                 540                 


Glu Gly Ser Asn Gly Glu Ile Thr Tyr Glu Ile Leu Val Gly Ala Gln 
545                 550                 555                 560 


Gly Asp Phe Ile Ile Asn Lys Thr Thr Gly Leu Ile Thr Ile Ala Pro 
                565                 570                 575     


Gly Val Glu Met Ile Val Gly Arg Thr Tyr Ala Leu Thr Val Gln Ala 
            580                 585                 590         


Ala Asp Asn Ala Pro Pro Ala Glu Arg Arg Asn Ser Ile Cys Thr Val 
        595                 600                 605             


Tyr Ile Glu Val Leu Pro Pro Asn Asn Gln Ser Pro Pro Arg Phe Pro 
    610                 615                 620                 


Gln Leu Met Tyr Ser Leu Glu Ile Ser Glu Ala Met Arg Val Gly Ala 
625                 630                 635                 640 


Val Leu Leu Asn Leu Gln Ala Thr Asp Arg Glu Gly Asp Ser Ile Thr 
                645                 650                 655     


Tyr Ala Ile Glu Asn Gly Asp Pro Gln Arg Val Phe Asn Leu Ser Glu 
            660                 665                 670         


Thr Thr Gly Ile Leu Thr Leu Gly Lys Ala Leu Asp Arg Glu Ser Thr 
        675                 680                 685             


Asp Arg Tyr Ile Leu Ile Ile Thr Ala Ser Asp Gly Arg Pro Asp Gly 
    690                 695                 700                 


Thr Ser Thr Ala Thr Val Asn Ile Val Val Thr Asp Val Asn Asp Asn 
705                 710                 715                 720 


Ala Pro Val Phe Asp Pro Tyr Leu Pro Arg Asn Leu Ser Val Val Glu 
                725                 730                 735     


Glu Glu Ala Asn Ala Phe Val Gly Gln Val Lys Ala Thr Asp Pro Asp 
            740                 745                 750         


Ala Gly Ile Asn Gly Gln Val His Tyr Ser Leu Gly Asn Phe Asn Asn 
        755                 760                 765             


Leu Phe Arg Ile Thr Ser Asn Gly Ser Ile Tyr Thr Ala Val Lys Leu 
    770                 775                 780                 


Asn Arg Glu Val Arg Asp Tyr Tyr Glu Leu Val Val Val Ala Thr Asp 
785                 790                 795                 800 


Gly Ala Val His Pro Arg His Ser Thr Leu Thr Leu Ala Ile Lys Val 
                805                 810                 815     


Leu Asp Ile Asp Asp Asn Ser Pro Val Phe Thr Asn Ser Thr Tyr Thr 
            820                 825                 830         


Val Leu Val Glu Glu Asn Leu Pro Ala Gly Thr Thr Ile Leu Gln Ile 
        835                 840                 845             


Glu Ala Lys Asp Val Asp Leu Gly Ala Asn Val Ser Tyr Arg Ile Arg 
    850                 855                 860                 


Ser Pro Glu Val Lys His Phe Phe Ala Leu His Pro Phe Thr Gly Glu 
865                 870                 875                 880 


Leu Ser Leu Leu Arg Ser Leu Asp Tyr Glu Ala Phe Pro Asp Gln Glu 
                885                 890                 895     


Ala Ser Ile Thr Phe Leu Val Glu Ala Phe Asp Ile Tyr Gly Thr Met 
            900                 905                 910         


Pro Pro Gly Ile Ala Thr Val Thr Val Ile Val Lys Asp Met Asn Asp 
        915                 920                 925             


Tyr Pro Pro Val Phe Ser Lys Arg Ile Tyr Lys Gly Met Val Ala Pro 
    930                 935                 940                 


Asp Ala Val Lys Gly Thr Pro Ile Thr Thr Val Tyr Ala Glu Asp Ala 
945                 950                 955                 960 


Asp Pro Pro Gly Leu Pro Ala Ser Arg Val Arg Tyr Arg Val Asp Asp 
                965                 970                 975     


Val Gln Phe Pro Tyr Pro Ala Ser Ile Phe Glu Val Glu Glu Asp Ser 
            980                 985                 990         


Gly Arg Val Ile Thr Arg Val Asn  Leu Asn Glu Glu Pro  Thr Thr Ile 
        995                 1000                 1005             


Phe Lys  Leu Val Val Val Ala  Phe Asp Asp Gly Glu  Pro Val Met 
    1010                 1015                 1020             


Ser Ser  Ser Ala Thr Val Lys  Ile Leu Val Leu His  Pro Gly Glu 
    1025                 1030                 1035             


Ile Pro  Arg Phe Thr Gln Glu  Glu Tyr Arg Pro Pro  Pro Val Ser 
    1040                 1045                 1050             


Glu Leu  Ala Thr Lys Gly Thr  Met Val Gly Val Ile  Ser Ala Ala 
    1055                 1060                 1065             


Ala Ile  Asn Gln Ser Ile Val  Tyr Ser Ile Val Ser  Gly Asn Glu 
    1070                 1075                 1080             


Glu Asp  Thr Phe Gly Ile Asn  Asn Ile Thr Gly Val  Ile Tyr Val 
    1085                 1090                 1095             


Asn Gly  Pro Leu Asp Tyr Glu  Thr Arg Thr Ser Tyr  Val Leu Arg 
    1100                 1105                 1110             


Val Gln  Ala Asp Ser Leu Glu  Val Val Leu Ala Asn  Leu Arg Val 
    1115                 1120                 1125             


Pro Ser  Lys Ser Asn Thr Ala  Lys Val Tyr Ile Glu  Ile Gln Asp 
    1130                 1135                 1140             


Glu Asn  Asn His Pro Pro Val  Phe Gln Lys Lys Phe  Tyr Ile Gly 
    1145                 1150                 1155             


Gly Val  Ser Glu Asp Ala Arg  Met Phe Thr Ser Val  Leu Arg Val 
    1160                 1165                 1170             


Lys Ala  Thr Asp Lys Asp Thr  Gly Asn Tyr Ser Val  Met Ala Tyr 
    1175                 1180                 1185             


Arg Leu  Ile Ile Pro Pro Ile  Lys Glu Gly Lys Glu  Gly Phe Val 
    1190                 1195                 1200             


Val Glu  Thr Tyr Thr Gly Leu  Ile Lys Thr Ala Met  Leu Phe His 
    1205                 1210                 1215             


Asn Met  Arg Arg Ser Tyr Phe  Lys Phe Gln Val Ile  Ala Thr Asp 
    1220                 1225                 1230             


Asp Tyr  Gly Lys Gly Leu Ser  Gly Lys Ala Asp Val  Leu Val Ser 
    1235                 1240                 1245             


Val Val  Asn Gln Leu Asp Met  Gln Val Ile Val Ser  Asn Val Pro 
    1250                 1255                 1260             


Pro Thr  Leu Val Glu Lys Lys  Ile Glu Asp Leu Thr  Glu Ile Leu 
    1265                 1270                 1275             


Asp Arg  Tyr Val Gln Glu Gln  Ile Pro Gly Ala Lys  Val Val Val 
    1280                 1285                 1290             


Glu Ser  Ile Gly Ala Arg Arg  His Gly Asp Ala Phe  Ser Leu Glu 
    1295                 1300                 1305             


Asp Tyr  Thr Lys Cys Asp Leu  Thr Val Tyr Ala Ile  Asp Pro Gln 
    1310                 1315                 1320             


Thr Asn  Arg Ala Ile Asp Arg  Asn Glu Leu Phe Lys  Phe Leu Asp 
    1325                 1330                 1335             


Gly Lys  Leu Leu Asp Ile Asn  Lys Asp Phe Gln Pro  Tyr Tyr Gly 
    1340                 1345                 1350             


Glu Gly  Gly Arg Ile Leu Glu  Ile Arg Thr Pro Glu  Ala Val Thr 
    1355                 1360                 1365             


Ser Ile  Lys Lys Arg Gly Glu  Ser Leu Gly Tyr Thr  Glu Gly Ala 
    1370                 1375                 1380             


Leu Leu  Ala Leu Ala Phe Ile  Ile Ile Leu Cys Cys  Ile Pro Ala 
    1385                 1390                 1395             


Ile Leu  Val Val Leu Val Ser  Tyr Arg Gln Phe Lys  Val Arg Gln 
    1400                 1405                 1410             


Ala Glu  Cys Thr Lys Thr Ala  Arg Ile Gln Ala Ala  Leu Pro Ala 
    1415                 1420                 1425             


Ala Lys  Pro Ala Val Pro Ala  Pro Ala Pro Val Ala  Ala Pro Pro 
    1430                 1435                 1440             


Pro Pro  Pro Pro Pro Pro Pro  Gly Ala His Leu Tyr  Glu Glu Leu 
    1445                 1450                 1455             


Gly Asp  Ser Ser Met Tyr Glu  Met Pro Gln Tyr Gly  Ser Arg Arg 
    1460                 1465                 1470             


Arg Leu  Leu Pro Pro Ala Gly  Gln Glu Glu Tyr Gly  Glu Val Val 
    1475                 1480                 1485             


Gly Glu  Ala Glu Glu Glu Tyr  Glu Glu Glu Glu Glu  Glu Pro Lys 
    1490                 1495                 1500             


Lys Ile  Lys Lys Pro Lys Val  Glu Ile Arg Glu Pro  Ser Glu Glu 
    1505                 1510                 1515             


Glu Glu  Val Val Val Thr Ile  Glu Lys Pro Pro Ala  Ala Glu Pro 
    1520                 1525                 1530             


Thr Tyr  Thr Thr Trp Lys Arg  Ala Arg Ile Phe Pro  Met Ile Phe 
    1535                 1540                 1545             


Lys Lys  Val Arg Gly Leu Ala  Asp Lys Arg Gly Ile  Val Asp Leu 
    1550                 1555                 1560             


Glu Gly  Glu Glu Trp Gln Arg  Arg Leu Glu Glu Glu  Asp Lys Asp 
    1565                 1570                 1575             


Tyr Leu  Lys Leu Thr Leu Asp  Gln Glu Glu Ala Thr  Glu Ser Thr 
    1580                 1585                 1590             


Val Glu  Ser Glu Glu Glu Ser  Ser Ser Asp Tyr Thr  Glu Tyr Ser 
    1595                 1600                 1605             


Glu Glu  Glu Ser Glu Phe Ser  Glu Ser Glu Thr Thr  Glu Glu Glu 
    1610                 1615                 1620             


Ser Glu  Ser Glu Thr Pro Ser  Glu Glu Glu Glu Ser  Ser Thr Pro 
    1625                 1630                 1635             


Glu Ser  Glu Glu Ser Glu Ser  Thr Glu Ser Glu Gly  Glu Lys Ala 
    1640                 1645                 1650             


Arg Lys  Asn Ile Val Leu Ala  Arg Arg Arg Pro Met  Val Glu Glu 
    1655                 1660                 1665             


Val Lys  Glu Val Lys Gly Arg  Lys Glu Glu Pro Gln  Glu Glu Gln 
    1670                 1675                 1680             


Lys Glu  Pro Lys Met Glu Glu  Glu Glu His Ser Glu  Glu Glu Glu 
    1685                 1690                 1695             


Ser Gly  Pro Ala Pro Val Glu  Glu Ser Thr Asp Pro  Glu Ala Gln 
    1700                 1705                 1710             


Asp Ile  Pro Glu Glu Gly Ser  Ala Glu Ser Ala Ser  Val Glu Gly 
    1715                 1720                 1725             


Gly Val  Glu Ser Glu Glu Glu  Ser Glu Ser Gly Ser  Ser Ser Ser 
    1730                 1735                 1740             


Ser Ser  Glu Ser Gln Ser Gly  Gly Pro Trp Gly Tyr  Gln Val Pro 
    1745                 1750                 1755             


Ala Tyr  Asp Arg Ser Lys Asn  Ala Asn Gln Lys Lys  Ser Pro Gly 
    1760                 1765                 1770             


Ala Asn  Ser Glu Gly Tyr Asn  Thr Ala Leu 
    1775                 1780             


<210>  10064
<211>  1886
<212>  PRT
<213>  Homo Sapiens

<400>  10064

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Cys 
            20                  25                  30          


Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile Val Ala Ile Asp Glu 
        35                  40                  45              


Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn Met Leu Ile Lys Gly 
    50                  55                  60                  


Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu Ser Leu Lys Asp Asn 
65                  70                  75                  80  


Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys Gln Met Leu Phe Leu 
                85                  90                  95      


Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro Pro Met Asn Ile His 
            100                 105                 110         


Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys Lys Val Gly Thr Ile 
        115                 120                 125             


Ile Tyr His Glu Val Arg Ile Val Val Arg Asp Arg Asn Asp Asn Ser 
    130                 135                 140                 


Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr Val Asn Glu Leu Thr 
145                 150                 155                 160 


Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser Gly Asp Asn Gly Ala 
                165                 170                 175     


Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile Glu Tyr Val Ile Gln 
            180                 185                 190         


Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr Phe Glu Ile Pro Leu 
        195                 200                 205             


Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg Leu Asn Tyr Glu Asp 
    210                 215                 220                 


Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn Asp Arg Ala Gln Asn 
225                 230                 235                 240 


Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu Thr Val Asp Val Leu 
                245                 250                 255     


Asp Gly Asp Asp Leu Gly Pro Met Phe Leu Pro Cys Val Leu Val Pro 
            260                 265                 270         


Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln Ala Ala Ile Pro Glu 
        275                 280                 285             


Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile Val Thr Pro Pro Ile 
    290                 295                 300                 


Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro Pro Ser Asp Arg Pro 
305                 310                 315                 320 


Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro Glu Asp Tyr Pro Arg 
                325                 330                 335     


Phe Phe His Met His Pro Arg Thr Ala Glu Leu Ser Leu Leu Glu Pro 
            340                 345                 350         


Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu Val Ile Lys Ala Glu 
        355                 360                 365             


Gln Asp Asn Gly His Pro Leu Pro Ala Phe Ala Gly Leu His Ile Glu 
    370                 375                 380                 


Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe Thr Met Pro Ser Tyr 
385                 390                 395                 400 


Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly Ala Thr Ile Ser Asp 
                405                 410                 415     


Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val Ala Leu Asp Lys Asp 
            420                 425                 430         


Ile Glu Asp Thr Lys Asp Pro Glu Leu His Leu Phe Leu Asn Asp Tyr 
        435                 440                 445             


Thr Ser Val Phe Thr Val Thr Gln Thr Gly Ile Thr Arg Tyr Leu Thr 
    450                 455                 460                 


Leu Leu Gln Pro Val Asp Arg Glu Glu Gln Gln Thr Tyr Thr Phe Ser 
465                 470                 475                 480 


Ile Thr Ala Phe Asp Gly Val Gln Glu Ser Glu Pro Val Ile Val Asn 
                485                 490                 495     


Ile Gln Val Met Asp Ala Asn Asp Asn Thr Pro Thr Phe Pro Glu Ile 
            500                 505                 510         


Ser Tyr Asp Val Tyr Val Tyr Thr Asp Met Arg Pro Gly Asp Ser Val 
        515                 520                 525             


Ile Gln Leu Thr Ala Val Asp Ala Asp Glu Gly Ser Asn Gly Glu Ile 
    530                 535                 540                 


Thr Tyr Glu Ile Leu Val Gly Ala Gln Gly Asp Phe Ile Ile Asn Lys 
545                 550                 555                 560 


Thr Thr Gly Leu Ile Thr Ile Ala Pro Gly Val Glu Met Ile Val Gly 
                565                 570                 575     


Arg Thr Tyr Ala Leu Thr Val Gln Ala Ala Asp Asn Ala Pro Pro Ala 
            580                 585                 590         


Glu Arg Ser Thr Gly Ile Leu Thr Leu Gly Lys Ala Leu Asp Arg Glu 
        595                 600                 605             


Ser Thr Asp Arg Tyr Ile Leu Ile Ile Thr Ala Ser Asp Gly Arg Pro 
    610                 615                 620                 


Asp Gly Thr Ser Thr Ala Thr Val Asn Ile Val Val Thr Asp Val Asn 
625                 630                 635                 640 


Asp Asn Ala Pro Val Phe Asp Pro Tyr Leu Pro Arg Asn Leu Ser Val 
                645                 650                 655     


Val Glu Glu Glu Ala Asn Ala Phe Val Gly Gln Val Lys Ala Thr Asp 
            660                 665                 670         


Pro Asp Ala Gly Ile Asn Gly Gln Val His Tyr Ser Leu Gly Asn Phe 
        675                 680                 685             


Asn Asn Leu Phe Arg Ile Thr Ser Asn Gly Ser Ile Tyr Thr Ala Val 
    690                 695                 700                 


Lys Leu Asn Arg Glu Val Arg Asp Tyr Tyr Glu Leu Val Val Val Ala 
705                 710                 715                 720 


Thr Asp Gly Ala Val His Pro Arg His Ser Thr Leu Thr Leu Ala Ile 
                725                 730                 735     


Lys Val Leu Asp Ile Asp Asp Asn Ser Pro Val Phe Thr Asn Ser Thr 
            740                 745                 750         


Tyr Thr Val Leu Val Glu Glu Asn Leu Pro Ala Gly Thr Thr Ile Leu 
        755                 760                 765             


Gln Ile Glu Ala Lys Asp Val Asp Leu Gly Ala Asn Val Ser Tyr Arg 
    770                 775                 780                 


Ile Arg Ser Pro Glu Val Lys His Phe Phe Ala Leu His Pro Phe Thr 
785                 790                 795                 800 


Gly Glu Leu Ser Leu Leu Arg Ser Leu Asp Tyr Glu Ala Phe Pro Asp 
                805                 810                 815     


Gln Glu Ala Ser Ile Thr Phe Leu Val Glu Ala Phe Asp Ile Tyr Gly 
            820                 825                 830         


Thr Met Pro Pro Gly Ile Ala Thr Val Thr Val Ile Val Lys Asp Met 
        835                 840                 845             


Asn Asp Tyr Pro Pro Val Phe Ser Lys Arg Ile Tyr Lys Gly Met Val 
    850                 855                 860                 


Ala Pro Asp Ala Val Lys Gly Thr Pro Ile Thr Thr Val Tyr Ala Glu 
865                 870                 875                 880 


Asp Ala Asp Pro Pro Gly Leu Pro Ala Ser Arg Val Arg Tyr Arg Val 
                885                 890                 895     


Asp Asp Val Gln Phe Pro Tyr Pro Ala Ser Ile Phe Glu Val Glu Glu 
            900                 905                 910         


Asp Ser Gly Arg Val Ile Thr Arg Val Asn Leu Asn Glu Glu Pro Thr 
        915                 920                 925             


Thr Ile Phe Lys Leu Val Val Val Ala Phe Asp Asp Gly Glu Pro Val 
    930                 935                 940                 


Met Ser Ser Ser Ala Thr Val Lys Ile Leu Val Leu His Pro Gly Glu 
945                 950                 955                 960 


Ile Pro Arg Phe Thr Gln Glu Glu Tyr Arg Pro Pro Pro Val Ser Glu 
                965                 970                 975     


Leu Ala Thr Lys Gly Thr Met Val Gly Val Ile Ser Ala Ala Ala Ile 
            980                 985                 990         


Asn Gln Ser Ile Val Tyr Ser Ile  Val Ser Gly Asn Glu  Glu Asp Thr 
        995                 1000                 1005             


Phe Gly  Ile Asn Asn Ile Thr  Gly Val Ile Tyr Val  Asn Gly Pro 
    1010                 1015                 1020             


Leu Asp  Tyr Glu Thr Arg Thr  Ser Tyr Val Leu Arg  Val Gln Ala 
    1025                 1030                 1035             


Asp Ser  Leu Glu Val Val Leu  Ala Asn Leu Arg Val  Pro Ser Lys 
    1040                 1045                 1050             


Ser Asn  Thr Ala Lys Val Tyr  Ile Glu Ile Gln Asp  Glu Asn Asn 
    1055                 1060                 1065             


His Pro  Pro Val Phe Gln Lys  Lys Phe Tyr Ile Gly  Gly Val Ser 
    1070                 1075                 1080             


Glu Asp  Ala Arg Met Phe Thr  Ser Val Leu Arg Val  Lys Ala Thr 
    1085                 1090                 1095             


Asp Lys  Asp Thr Gly Asn Tyr  Ser Val Met Ala Tyr  Arg Leu Ile 
    1100                 1105                 1110             


Ile Pro  Pro Ile Lys Glu Gly  Lys Glu Gly Phe Val  Val Glu Thr 
    1115                 1120                 1125             


Tyr Thr  Gly Leu Ile Lys Thr  Ala Met Leu Phe His  Asn Met Arg 
    1130                 1135                 1140             


Arg Ser  Tyr Phe Lys Phe Gln  Val Ile Ala Thr Asp  Asp Tyr Gly 
    1145                 1150                 1155             


Lys Gly  Leu Ser Gly Lys Ala  Asp Val Leu Val Ser  Val Val Asn 
    1160                 1165                 1170             


Gln Leu  Asp Met Gln Val Ile  Val Ser Asn Val Pro  Pro Thr Leu 
    1175                 1180                 1185             


Val Glu  Lys Lys Ile Glu Asp  Leu Thr Glu Ile Leu  Asp Arg Tyr 
    1190                 1195                 1200             


Val Gln  Glu Gln Ile Pro Gly  Ala Lys Val Val Val  Glu Ser Ile 
    1205                 1210                 1215             


Gly Ala  Arg Arg His Gly Asp  Ala Phe Ser Leu Glu  Asp Tyr Thr 
    1220                 1225                 1230             


Lys Cys  Asp Leu Thr Val Tyr  Ala Ile Asp Pro Gln  Thr Asn Arg 
    1235                 1240                 1245             


Ala Ile  Asp Arg Asn Glu Leu  Phe Lys Phe Leu Asp  Gly Lys Leu 
    1250                 1255                 1260             


Leu Asp  Ile Asn Lys Asp Phe  Gln Pro Tyr Tyr Gly  Glu Gly Gly 
    1265                 1270                 1275             


Arg Ile  Leu Glu Ile Arg Thr  Pro Glu Ala Val Thr  Ser Ile Lys 
    1280                 1285                 1290             


Lys Arg  Gly Glu Ser Leu Gly  Tyr Thr Glu Gly Ala  Leu Leu Ala 
    1295                 1300                 1305             


Leu Ala  Phe Ile Ile Ile Leu  Cys Cys Ile Pro Ala  Ile Leu Val 
    1310                 1315                 1320             


Val Leu  Val Ser Tyr Arg Gln  Phe Lys Val Arg Gln  Ala Glu Cys 
    1325                 1330                 1335             


Thr Lys  Thr Ala Arg Ile Gln  Ala Ala Leu Pro Ala  Ala Lys Pro 
    1340                 1345                 1350             


Ala Val  Pro Ala Pro Ala Pro  Val Ala Ala Pro Pro  Pro Pro Pro 
    1355                 1360                 1365             


Pro Pro  Pro Pro Gly Ala His  Leu Tyr Glu Glu Leu  Gly Asp Ser 
    1370                 1375                 1380             


Ser Met  His Asn Leu Phe Leu  Leu Tyr His Phe Gln  Gln Ser Arg 
    1385                 1390                 1395             


Gly Asn  Asn Ser Val Ser Glu  Asp Arg Lys His Gln  Gln Val Val 
    1400                 1405                 1410             


Met Pro  Phe Ser Ser Asn Thr  Ile Glu Ala His Lys  Ser Ala His 
    1415                 1420                 1425             


Val Asp  Gly Ser Leu Lys Ser  Asn Lys Leu Lys Ser  Ala Arg Lys 
    1430                 1435                 1440             


Phe Thr  Phe Leu Ser Asp Glu  Asp Asp Leu Ser Ala  His Asn Pro 
    1445                 1450                 1455             


Leu Tyr  Lys Glu Asn Ile Ser  Gln Val Ser Thr Asn  Ser Asp Ile 
    1460                 1465                 1470             


Ser Gln  Arg Thr Asp Phe Val  Asp Pro Phe Ser Pro  Lys Ile Gln 
    1475                 1480                 1485             


Ala Lys  Ser Lys Ser Leu Arg  Gly Pro Arg Glu Lys  Ile Gln Arg 
    1490                 1495                 1500             


Leu Trp  Ser Gln Ser Val Ser  Leu Pro Arg Arg Leu  Met Arg Lys 
    1505                 1510                 1515             


Val Pro  Asn Arg Pro Glu Ile  Ile Asp Leu Gln Gln  Trp Gln Gly 
    1520                 1525                 1530             


Thr Arg  Gln Lys Ala Glu Asn  Glu Asn Thr Gly Ile  Cys Thr Asn 
    1535                 1540                 1545             


Lys Arg  Gly Ser Ser Asn Pro  Leu Leu Thr Thr Glu  Glu Ala Asn 
    1550                 1555                 1560             


Leu Thr  Glu Lys Glu Glu Ile  Arg Gln Gly Glu Thr  Leu Met Ile 
    1565                 1570                 1575             


Glu Gly  Thr Glu Gln Leu Lys  Ser Leu Ser Ser Asp  Ser Ser Phe 
    1580                 1585                 1590             


Cys Phe  Pro Arg Pro His Phe  Ser Phe Ser Thr Leu  Pro Thr Val 
    1595                 1600                 1605             


Ser Arg  Thr Val Glu Leu Lys  Ser Glu Pro Asn Val  Ile Ser Ser 
    1610                 1615                 1620             


Pro Ala  Glu Cys Ser Leu Glu  Leu Ser Pro Ser Arg  Pro Cys Val 
    1625                 1630                 1635             


Leu His  Ser Ser Leu Ser Arg  Arg Glu Thr Pro Ile  Cys Met Leu 
    1640                 1645                 1650             


Pro Ile  Glu Thr Glu Arg Asn  Ile Phe Glu Asn Phe  Ala His Pro 
    1655                 1660                 1665             


Pro Asn  Ile Ser Pro Ser Ala  Cys Pro Leu Pro Pro  Pro Pro Pro 
    1670                 1675                 1680             


Ile Ser  Pro Pro Ser Pro Pro  Pro Ala Pro Ala Pro  Leu Ala Pro 
    1685                 1690                 1695             


Pro Pro  Asp Ile Ser Pro Phe  Ser Leu Phe Cys Pro  Pro Pro Ser 
    1700                 1705                 1710             


Pro Pro  Ser Ile Pro Leu Pro  Leu Pro Pro Pro Thr  Phe Phe Pro 
    1715                 1720                 1725             


Leu Ser  Val Ser Thr Ser Gly  Pro Pro Thr Pro Pro  Leu Leu Pro 
    1730                 1735                 1740             


Pro Phe  Pro Thr Pro Leu Pro  Pro Pro Pro Pro Ser  Ile Pro Cys 
    1745                 1750                 1755             


Pro Pro  Pro Pro Ser Ala Ser  Phe Leu Ser Thr Glu  Cys Val Cys 
    1760                 1765                 1770             


Ile Thr  Gly Val Lys Cys Thr  Thr Asn Leu Met Pro  Ala Glu Lys 
    1775                 1780                 1785             


Ile Lys  Ser Ser Met Thr Gln  Leu Ser Thr Thr Thr  Val Cys Lys 
    1790                 1795                 1800             


Thr Asp  Pro Gln Arg Glu Pro  Lys Gly Ile Leu Arg  His Val Lys 
    1805                 1810                 1815             


Asn Leu  Ala Glu Leu Glu Lys  Ser Val Ala Asn Met  Tyr Ser Gln 
    1820                 1825                 1830             


Ile Glu  Lys Asn Tyr Leu Arg  Thr Asn Val Ser Glu  Leu Gln Thr 
    1835                 1840                 1845             


Met Cys  Pro Ser Glu Val Thr  Asn Met Glu Ile Thr  Ser Glu Gln 
    1850                 1855                 1860             


Asn Lys  Gly Ser Leu Asn Asn  Ile Val Glu Gly Thr  Glu Lys Gln 
    1865                 1870                 1875             


Ser His  Ser Gln Ser Thr Ser  Leu 
    1880                 1885     


<210>  10065
<211>  1676
<212>  PRT
<213>  Homo Sapiens

<400>  10065

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Cys 
            20                  25                  30          


Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile Val Ala Ile Asp Glu 
        35                  40                  45              


Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn Met Leu Ile Lys Gly 
    50                  55                  60                  


Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu Ser Leu Lys Asp Asn 
65                  70                  75                  80  


Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys Gln Met Leu Phe Leu 
                85                  90                  95      


Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro Pro Met Asn Ile His 
            100                 105                 110         


Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys Lys Val Gly Thr Ile 
        115                 120                 125             


Ile Tyr His Glu Val Arg Ile Val Val Arg Asp Arg Asn Asp Asn Ser 
    130                 135                 140                 


Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr Val Asn Glu Leu Thr 
145                 150                 155                 160 


Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser Gly Asp Asn Gly Ala 
                165                 170                 175     


Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile Glu Tyr Val Ile Gln 
            180                 185                 190         


Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr Phe Glu Ile Pro Leu 
        195                 200                 205             


Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg Leu Asn Tyr Glu Asp 
    210                 215                 220                 


Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn Asp Arg Ala Gln Asn 
225                 230                 235                 240 


Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu Thr Val Asp Val Leu 
                245                 250                 255     


Asp Gly Asp Asp Leu Gly Pro Met Phe Leu Pro Cys Val Leu Val Pro 
            260                 265                 270         


Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln Ala Ala Ile Pro Glu 
        275                 280                 285             


Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile Val Thr Pro Pro Ile 
    290                 295                 300                 


Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro Pro Ser Asp Arg Pro 
305                 310                 315                 320 


Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro Glu Asp Tyr Pro Arg 
                325                 330                 335     


Phe Phe His Met His Pro Arg Thr Ala Glu Leu Ser Leu Leu Glu Pro 
            340                 345                 350         


Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu Val Ile Lys Ala Glu 
        355                 360                 365             


Gln Asp Asn Gly His Pro Leu Pro Ala Phe Ala Gly Leu His Ile Glu 
    370                 375                 380                 


Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe Thr Met Pro Ser Tyr 
385                 390                 395                 400 


Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly Ala Thr Ile Ser Asp 
                405                 410                 415     


Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val Ala Leu Asp Lys Asp 
            420                 425                 430         


Ile Glu Asp Thr Lys Asp Pro Glu Leu His Leu Phe Leu Asn Asp Tyr 
        435                 440                 445             


Thr Ser Val Phe Thr Val Thr Gln Thr Gly Ile Thr Arg Tyr Leu Thr 
    450                 455                 460                 


Leu Leu Gln Pro Val Asp Arg Glu Glu Gln Gln Thr Tyr Thr Phe Ser 
465                 470                 475                 480 


Ile Thr Ala Phe Asp Gly Val Gln Glu Ser Glu Pro Val Ile Val Asn 
                485                 490                 495     


Ile Gln Val Met Asp Ala Asn Asp Asn Thr Pro Thr Phe Pro Glu Ile 
            500                 505                 510         


Ser Tyr Asp Val Tyr Val Tyr Thr Asp Met Arg Pro Gly Asp Ser Val 
        515                 520                 525             


Ile Gln Leu Thr Ala Val Asp Ala Asp Glu Gly Ser Asn Gly Glu Ile 
    530                 535                 540                 


Thr Tyr Glu Ile Leu Val Gly Ala Gln Gly Asp Phe Ile Ile Asn Lys 
545                 550                 555                 560 


Thr Thr Gly Leu Ile Thr Ile Ala Pro Gly Val Glu Met Ile Val Gly 
                565                 570                 575     


Arg Thr Tyr Ala Leu Thr Val Gln Ala Ala Asp Asn Ala Pro Pro Ala 
            580                 585                 590         


Glu Arg Arg Asn Ser Ile Cys Thr Val Tyr Ile Glu Val Leu Pro Pro 
        595                 600                 605             


Asn Asn Gln Ser Pro Pro Arg Phe Pro Gln Leu Met Tyr Ser Leu Glu 
    610                 615                 620                 


Ile Ser Glu Ala Met Arg Val Gly Ala Val Leu Leu Asn Leu Gln Ala 
625                 630                 635                 640 


Thr Asp Arg Glu Gly Asp Ser Ile Thr Tyr Ala Ile Glu Asn Gly Asp 
                645                 650                 655     


Pro Gln Arg Val Phe Asn Leu Ser Glu Thr Thr Gly Ile Leu Thr Leu 
            660                 665                 670         


Gly Lys Ala Leu Asp Arg Glu Ser Thr Asp Arg Tyr Ile Leu Ile Ile 
        675                 680                 685             


Thr Ala Ser Asp Gly Arg Pro Asp Gly Thr Ser Thr Ala Thr Val Asn 
    690                 695                 700                 


Ile Val Val Thr Asp Val Asn Asp Asn Ala Pro Val Phe Asp Pro Tyr 
705                 710                 715                 720 


Leu Pro Arg Asn Leu Ser Val Val Glu Glu Glu Ala Asn Ala Phe Val 
                725                 730                 735     


Gly Gln Val Lys Ala Thr Asp Pro Asp Ala Gly Ile Asn Gly Gln Val 
            740                 745                 750         


His Tyr Ser Leu Gly Asn Phe Asn Asn Leu Phe Arg Ile Thr Ser Asn 
        755                 760                 765             


Gly Ser Ile Tyr Thr Ala Val Lys Leu Asn Arg Glu Val Arg Asp Tyr 
    770                 775                 780                 


Tyr Glu Leu Val Val Val Ala Thr Asp Gly Ala Val His Pro Arg His 
785                 790                 795                 800 


Ser Thr Leu Thr Leu Ala Ile Lys Val Leu Asp Ile Asp Asp Asn Ser 
                805                 810                 815     


Pro Val Phe Thr Asn Ser Thr Tyr Thr Val Leu Val Glu Glu Asn Leu 
            820                 825                 830         


Pro Ala Gly Thr Thr Ile Leu Gln Ile Glu Ala Lys Asp Val Asp Leu 
        835                 840                 845             


Gly Ala Asn Val Ser Tyr Arg Ile Arg Ser Pro Glu Val Lys His Phe 
    850                 855                 860                 


Phe Ala Leu His Pro Phe Thr Gly Glu Leu Ser Leu Leu Arg Ser Leu 
865                 870                 875                 880 


Asp Tyr Glu Ala Phe Pro Asp Gln Glu Ala Ser Ile Thr Phe Leu Val 
                885                 890                 895     


Glu Ala Phe Asp Ile Tyr Gly Thr Met Pro Pro Gly Ile Ala Thr Val 
            900                 905                 910         


Thr Val Ile Val Lys Asp Met Asn Asp Tyr Pro Pro Val Phe Ser Lys 
        915                 920                 925             


Arg Ile Tyr Lys Gly Met Val Ala Pro Asp Ala Val Lys Gly Thr Pro 
    930                 935                 940                 


Ile Thr Thr Val Tyr Ala Glu Asp Ala Asp Pro Pro Gly Leu Pro Ala 
945                 950                 955                 960 


Ser Arg Val Arg Tyr Arg Val Asp Asp Val Gln Phe Pro Tyr Pro Ala 
                965                 970                 975     


Ser Ile Phe Glu Val Glu Glu Asp Ser Gly Arg Val Ile Thr Arg Val 
            980                 985                 990         


Asn Leu Asn Glu Glu Pro Thr Thr  Ile Phe Lys Leu Val  Val Val Ala 
        995                 1000                 1005             


Phe Asp  Asp Gly Glu Pro Val  Met Ser Ser Ser Ala  Thr Val Lys 
    1010                 1015                 1020             


Ile Leu  Val Leu His Pro Gly  Glu Ile Pro Arg Phe  Thr Gln Glu 
    1025                 1030                 1035             


Glu Tyr  Arg Pro Pro Pro Val  Ser Glu Leu Ala Thr  Lys Gly Thr 
    1040                 1045                 1050             


Met Val  Gly Val Ile Ser Ala  Ala Ala Ile Asn Gln  Ser Ile Val 
    1055                 1060                 1065             


Tyr Ser  Ile Val Ser Gly Asn  Glu Glu Asp Thr Phe  Gly Ile Asn 
    1070                 1075                 1080             


Asn Ile  Thr Gly Val Ile Tyr  Val Asn Gly Pro Leu  Asp Tyr Glu 
    1085                 1090                 1095             


Thr Arg  Thr Ser Tyr Val Leu  Arg Val Gln Ala Asp  Ser Leu Glu 
    1100                 1105                 1110             


Val Val  Leu Ala Asn Leu Arg  Val Pro Ser Lys Ser  Asn Thr Ala 
    1115                 1120                 1125             


Lys Val  Tyr Ile Glu Ile Gln  Asp Glu Asn Asn His  Pro Pro Val 
    1130                 1135                 1140             


Phe Gln  Lys Lys Phe Tyr Ile  Gly Gly Val Ser Glu  Asp Ala Arg 
    1145                 1150                 1155             


Met Phe  Thr Ser Val Leu Arg  Val Lys Ala Thr Asp  Lys Asp Thr 
    1160                 1165                 1170             


Gly Asn  Tyr Ser Val Met Ala  Tyr Arg Leu Ile Ile  Pro Pro Ile 
    1175                 1180                 1185             


Lys Glu  Gly Lys Glu Gly Phe  Val Val Glu Thr Tyr  Thr Gly Leu 
    1190                 1195                 1200             


Ile Lys  Thr Ala Met Leu Phe  His Asn Met Arg Arg  Ser Tyr Phe 
    1205                 1210                 1215             


Lys Phe  Gln Val Ile Ala Thr  Asp Asp Tyr Gly Lys  Gly Leu Ser 
    1220                 1225                 1230             


Gly Lys  Ala Asp Val Leu Val  Ser Val Val Asn Gln  Leu Asp Met 
    1235                 1240                 1245             


Gln Val  Ile Val Ser Asn Val  Pro Pro Thr Leu Val  Glu Lys Lys 
    1250                 1255                 1260             


Ile Glu  Asp Leu Thr Glu Ile  Leu Asp Arg Tyr Val  Gln Glu Gln 
    1265                 1270                 1275             


Ile Pro  Gly Ala Lys Val Val  Val Glu Ser Ile Gly  Ala Arg Arg 
    1280                 1285                 1290             


His Gly  Asp Ala Phe Ser Leu  Glu Asp Tyr Thr Lys  Cys Asp Leu 
    1295                 1300                 1305             


Thr Val  Tyr Ala Ile Asp Pro  Gln Thr Asn Arg Ala  Ile Asp Arg 
    1310                 1315                 1320             


Asn Glu  Leu Phe Lys Phe Leu  Asp Gly Lys Leu Leu  Asp Ile Asn 
    1325                 1330                 1335             


Lys Asp  Phe Gln Pro Tyr Tyr  Gly Glu Gly Gly Arg  Ile Leu Glu 
    1340                 1345                 1350             


Ile Arg  Thr Pro Glu Ala Val  Thr Ser Ile Lys Lys  Arg Gly Glu 
    1355                 1360                 1365             


Ser Leu  Gly Tyr Thr Glu Gly  Ala Leu Leu Ala Leu  Ala Phe Ile 
    1370                 1375                 1380             


Ile Ile  Leu Cys Cys Ile Pro  Ala Ile Leu Val Val  Leu Val Ser 
    1385                 1390                 1395             


Tyr Arg  Gln Val Phe Lys Gly  Arg Gln Ala Glu Cys  Thr Lys Thr 
    1400                 1405                 1410             


Ala Arg  Ile Gln Ala Ala Leu  Pro Ala Ala Lys Pro  Ala Val Pro 
    1415                 1420                 1425             


Ala Pro  Ala Pro Val Ala Ala  Pro Pro Pro Pro Pro  Pro Pro Pro 
    1430                 1435                 1440             


Pro Gly  Ala His Leu Tyr Glu  Glu Leu Gly Asp Ser  Ser Met Tyr 
    1445                 1450                 1455             


Glu Met  Pro Gln Tyr Gly Ser  Arg Arg Arg Leu Leu  Pro Pro Ala 
    1460                 1465                 1470             


Gly Gln  Glu Glu Tyr Gly Glu  Val Val Gly Glu Ala  Glu Glu Glu 
    1475                 1480                 1485             


Tyr Glu  Glu Glu Glu Trp Ala  Arg Lys Arg Met Ile  Lys Leu Val 
    1490                 1495                 1500             


Val Asp  Arg Glu Tyr Glu Thr  Ser Ser Thr Gly Glu  Asp Ser Ala 
    1505                 1510                 1515             


Pro Glu  Cys Gln Arg Asn Arg  Leu His His Pro Ser  Ile His Ser 
    1520                 1525                 1530             


Asn Ile  Asn Gly Asn Ile Tyr  Ile Ala Gln Asn Gly  Ser Val Val 
    1535                 1540                 1545             


Arg Thr  Arg Arg Ala Cys Leu  Thr Asp Asn Leu Lys  Val Ala Ser 
    1550                 1555                 1560             


Pro Val  Arg Leu Gly Gly Pro  Phe Lys Lys Leu Asp  Lys Leu Ala 
    1565                 1570                 1575             


Val Thr  His Glu Glu Asn Val  Pro Leu Asn Thr Leu  Ser Lys Gly 
    1580                 1585                 1590             


Pro Phe  Ser Thr Glu Lys Met  Asn Ala Arg Pro Thr  Leu Val Thr 
    1595                 1600                 1605             


Phe Ala  Pro Cys Pro Val Gly  Thr Asp Asn Thr Ala  Val Lys Pro 
    1610                 1615                 1620             


Leu Arg  Asn Arg Leu Lys Ser  Thr Val Glu Gln Glu  Ser Met Ile 
    1625                 1630                 1635             


Asp Ser  Lys Asn Ile Lys Glu  Ala Leu Glu Phe His  Ser Asp His 
    1640                 1645                 1650             


Thr Gln  Ser Asp Asp Glu Glu  Leu Trp Met Gly Pro  Trp Asn Asn 
    1655                 1660                 1665             


Leu His  Ile Pro Met Thr Lys  Leu 
    1670                 1675     


<210>  10066
<211>  650
<212>  PRT
<213>  Homo Sapiens

<400>  10066

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Cys 
            20                  25                  30          


Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile Val Ala Ile Asp Glu 
        35                  40                  45              


Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn Met Leu Ile Lys Gly 
    50                  55                  60                  


Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu Ser Leu Lys Asp Asn 
65                  70                  75                  80  


Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys Gln Met Leu Phe Leu 
                85                  90                  95      


Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro Pro Met Asn Ile His 
            100                 105                 110         


Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys Lys Val Gly Thr Ile 
        115                 120                 125             


Ile Tyr His Glu Val Arg Ile Val Val Arg Asp Arg Asn Asp Asn Ser 
    130                 135                 140                 


Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr Val Asn Glu Leu Thr 
145                 150                 155                 160 


Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser Gly Asp Asn Gly Ala 
                165                 170                 175     


Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile Glu Tyr Val Ile Gln 
            180                 185                 190         


Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr Phe Glu Ile Pro Leu 
        195                 200                 205             


Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg Leu Asn Tyr Glu Asp 
    210                 215                 220                 


Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn Asp Arg Ala Gln Asn 
225                 230                 235                 240 


Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu Thr Val Asp Val Leu 
                245                 250                 255     


Asp Gly Asp Asp Leu Gly Pro Met Phe Leu Pro Cys Val Leu Val Pro 
            260                 265                 270         


Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln Ala Ala Ile Pro Glu 
        275                 280                 285             


Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile Val Thr Pro Pro Ile 
    290                 295                 300                 


Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro Pro Ser Asp Arg Pro 
305                 310                 315                 320 


Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro Glu Asp Tyr Pro Arg 
                325                 330                 335     


Phe Phe His Met His Pro Arg Thr Ala Glu Leu Ser Leu Leu Glu Pro 
            340                 345                 350         


Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu Val Ile Lys Glu Glu 
        355                 360                 365             


Pro Lys Lys Ile Lys Lys Pro Lys Val Glu Ile Arg Glu Pro Ser Glu 
    370                 375                 380                 


Glu Glu Glu Val Val Val Thr Ile Glu Lys Pro Pro Ala Ala Glu Pro 
385                 390                 395                 400 


Thr Tyr Thr Thr Trp Lys Arg Ala Arg Ile Phe Pro Met Ile Phe Lys 
                405                 410                 415     


Lys Val Arg Gly Leu Ala Asp Lys Arg Gly Ile Val Asp Leu Glu Gly 
            420                 425                 430         


Glu Glu Trp Gln Arg Arg Leu Glu Glu Glu Asp Lys Asp Tyr Leu Lys 
        435                 440                 445             


Leu Thr Leu Asp Gln Glu Glu Ala Thr Glu Ser Thr Val Glu Ser Glu 
    450                 455                 460                 


Glu Glu Ser Ser Ser Asp Tyr Thr Glu Tyr Ser Glu Glu Glu Ser Glu 
465                 470                 475                 480 


Phe Ser Glu Ser Glu Thr Thr Glu Glu Glu Ser Glu Ser Glu Thr Pro 
                485                 490                 495     


Ser Glu Glu Glu Glu Ser Ser Thr Pro Glu Ser Glu Glu Ser Glu Ser 
            500                 505                 510         


Thr Glu Ser Glu Gly Glu Lys Ala Arg Lys Asn Ile Val Leu Ala Arg 
        515                 520                 525             


Arg Arg Pro Met Val Glu Glu Val Lys Glu Val Lys Gly Arg Lys Glu 
    530                 535                 540                 


Glu Pro Gln Glu Glu Gln Lys Glu Pro Lys Met Glu Glu Glu Glu His 
545                 550                 555                 560 


Ser Glu Glu Glu Glu Ser Gly Pro Ala Pro Val Glu Glu Ser Thr Asp 
                565                 570                 575     


Pro Glu Ala Gln Asp Ile Pro Glu Glu Gly Ser Ala Glu Ser Ala Ser 
            580                 585                 590         


Val Glu Gly Gly Val Glu Ser Glu Glu Glu Ser Glu Ser Gly Ser Ser 
        595                 600                 605             


Ser Ser Ser Ser Glu Ser Gln Ser Gly Gly Pro Trp Gly Tyr Gln Val 
    610                 615                 620                 


Pro Ala Tyr Asp Arg Ser Lys Asn Ala Asn Gln Lys Lys Ser Pro Gly 
625                 630                 635                 640 


Ala Asn Ser Glu Gly Tyr Asn Thr Ala Leu 
                645                 650 


<210>  10067
<211>  981
<212>  PRT
<213>  Homo Sapiens

<400>  10067

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Cys 
            20                  25                  30          


Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile Val Ala Ile Asp Glu 
        35                  40                  45              


Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn Met Leu Ile Lys Gly 
    50                  55                  60                  


Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu Ser Leu Lys Asp Asn 
65                  70                  75                  80  


Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys Gln Met Leu Phe Leu 
                85                  90                  95      


Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro Pro Met Asn Ile His 
            100                 105                 110         


Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys Lys Val Gly Thr Ile 
        115                 120                 125             


Ile Tyr His Glu Val Arg Ile Val Val Arg Asp Arg Asn Asp Asn Ser 
    130                 135                 140                 


Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr Val Asn Glu Leu Thr 
145                 150                 155                 160 


Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser Gly Asp Asn Gly Ala 
                165                 170                 175     


Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile Glu Tyr Val Ile Gln 
            180                 185                 190         


Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr Phe Glu Ile Pro Leu 
        195                 200                 205             


Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg Leu Asn Tyr Glu Asp 
    210                 215                 220                 


Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn Asp Arg Ala Gln Asn 
225                 230                 235                 240 


Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu Thr Val Asp Val Leu 
                245                 250                 255     


Asp Gly Asp Asp Leu Gly Pro Met Phe Leu Pro Cys Val Leu Val Pro 
            260                 265                 270         


Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln Ala Ala Ile Pro Glu 
        275                 280                 285             


Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile Val Thr Pro Pro Ile 
    290                 295                 300                 


Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro Pro Ser Asp Arg Pro 
305                 310                 315                 320 


Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro Glu Asp Tyr Pro Arg 
                325                 330                 335     


Phe Phe His Met His Pro Arg Thr Ala Glu Leu Ser Leu Leu Glu Pro 
            340                 345                 350         


Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu Val Ile Lys Ala Glu 
        355                 360                 365             


Gln Asp Asn Gly His Pro Leu Pro Ala Phe Ala Gly Leu His Ile Glu 
    370                 375                 380                 


Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe Thr Met Pro Ser Tyr 
385                 390                 395                 400 


Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly Ala Thr Ile Ser Asp 
                405                 410                 415     


Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val Ala Leu Asp Lys Asp 
            420                 425                 430         


Ile Glu Asp Thr Lys Asp Pro Glu Leu His Leu Phe Leu Asn Asp Tyr 
        435                 440                 445             


Thr Ser Val Phe Thr Val Thr Gln Thr Gly Ile Thr Arg Tyr Leu Thr 
    450                 455                 460                 


Leu Leu Gln Pro Val Asp Arg Glu Glu Gln Gln Thr Tyr Thr Phe Ser 
465                 470                 475                 480 


Ile Thr Ala Phe Asp Gly Val Gln Glu Ser Glu Pro Val Ile Val Asn 
                485                 490                 495     


Ile Gln Val Met Asp Ala Asn Asp Asn Thr Pro Thr Phe Pro Glu Ile 
            500                 505                 510         


Ser Tyr Asp Val Tyr Val Tyr Thr Asp Met Arg Pro Gly Asp Ser Val 
        515                 520                 525             


Ile Gln Leu Thr Ala Val Asp Ala Asp Glu Gly Ser Asn Gly Glu Ile 
    530                 535                 540                 


Thr Tyr Glu Ile Leu Val Gly Ala Gln Gly Asp Phe Ile Ile Asn Lys 
545                 550                 555                 560 


Thr Thr Gly Leu Ile Thr Ile Ala Pro Gly Val Glu Met Ile Val Gly 
                565                 570                 575     


Arg Thr Tyr Ala Leu Thr Val Gln Ala Ala Asp Asn Ala Pro Pro Ala 
            580                 585                 590         


Glu Arg Arg Asn Ser Ile Cys Thr Val Tyr Ile Glu Val Leu Pro Pro 
        595                 600                 605             


Asn Asn Gln Ser Pro Pro Arg Phe Pro Gln Leu Met Tyr Ser Leu Glu 
    610                 615                 620                 


Ile Ser Glu Ala Met Arg Val Gly Ala Val Leu Leu Asn Leu Gln Ala 
625                 630                 635                 640 


Thr Asp Arg Glu Gly Asp Ser Ile Thr Tyr Ala Ile Glu Asn Gly Asp 
                645                 650                 655     


Pro Gln Arg Val Phe Asn Leu Ser Glu Thr Thr Gly Ile Leu Thr Leu 
            660                 665                 670         


Gly Lys Ala Leu Asp Arg Glu Ser Thr Asp Arg Tyr Ile Leu Ile Ile 
        675                 680                 685             


Thr Ala Ser Asp Gly Arg Pro Asp Gly Glu Glu Pro Lys Lys Ile Lys 
    690                 695                 700                 


Lys Pro Lys Val Glu Ile Arg Glu Pro Ser Glu Glu Glu Glu Val Val 
705                 710                 715                 720 


Val Thr Ile Glu Lys Pro Pro Ala Ala Glu Pro Thr Tyr Thr Thr Trp 
                725                 730                 735     


Lys Arg Ala Arg Ile Phe Pro Met Ile Phe Lys Lys Val Arg Gly Leu 
            740                 745                 750         


Ala Asp Lys Arg Gly Ile Val Asp Leu Glu Gly Glu Glu Trp Gln Arg 
        755                 760                 765             


Arg Leu Glu Glu Glu Asp Lys Asp Tyr Leu Lys Leu Thr Leu Asp Gln 
    770                 775                 780                 


Glu Glu Ala Thr Glu Ser Thr Val Glu Ser Glu Glu Glu Ser Ser Ser 
785                 790                 795                 800 


Asp Tyr Thr Glu Tyr Ser Glu Glu Glu Ser Glu Phe Ser Glu Ser Glu 
                805                 810                 815     


Thr Thr Glu Glu Glu Ser Glu Ser Glu Thr Pro Ser Glu Glu Glu Glu 
            820                 825                 830         


Ser Ser Thr Pro Glu Ser Glu Glu Ser Glu Ser Thr Glu Ser Glu Gly 
        835                 840                 845             


Glu Lys Ala Arg Lys Asn Ile Val Leu Ala Arg Arg Arg Pro Met Val 
    850                 855                 860                 


Glu Glu Val Lys Glu Val Lys Gly Arg Lys Glu Glu Pro Gln Glu Glu 
865                 870                 875                 880 


Gln Lys Glu Pro Lys Met Glu Glu Glu Glu His Ser Glu Glu Glu Glu 
                885                 890                 895     


Ser Gly Pro Ala Pro Val Glu Glu Ser Thr Asp Pro Glu Ala Gln Asp 
            900                 905                 910         


Ile Pro Glu Glu Gly Ser Ala Glu Ser Ala Ser Val Glu Gly Gly Val 
        915                 920                 925             


Glu Ser Glu Glu Glu Ser Glu Ser Gly Ser Ser Ser Ser Ser Ser Glu 
    930                 935                 940                 


Ser Gln Ser Gly Gly Pro Trp Gly Tyr Gln Val Pro Ala Tyr Asp Arg 
945                 950                 955                 960 


Ser Lys Asn Ala Asn Gln Lys Lys Ser Pro Gly Ala Asn Ser Glu Gly 
                965                 970                 975     


Tyr Asn Thr Ala Leu 
            980     


<210>  10068
<211>  329
<212>  PRT
<213>  Homo Sapiens

<400>  10068

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Cys 
            20                  25                  30          


Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile Val Ala Ile Asp Glu 
        35                  40                  45              


Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn Met Leu Ile Lys Gly 
    50                  55                  60                  


Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu Ser Leu Lys Asp Asn 
65                  70                  75                  80  


Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys Gln Met Leu Phe Leu 
                85                  90                  95      


Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro Pro Met Asn Ile His 
            100                 105                 110         


Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys Lys Val Gly Thr Ile 
        115                 120                 125             


Ile Tyr His Glu Val Arg Ile Val Val Arg Asp Arg Asn Asp Asn Ser 
    130                 135                 140                 


Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr Val Asn Glu Leu Thr 
145                 150                 155                 160 


Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser Gly Asp Asn Gly Ala 
                165                 170                 175     


Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile Glu Tyr Val Ile Gln 
            180                 185                 190         


Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr Phe Glu Ile Pro Leu 
        195                 200                 205             


Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg Leu Asn Tyr Glu Asp 
    210                 215                 220                 


Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn Asp Arg Ala Gln Asn 
225                 230                 235                 240 


Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu Thr Val Asp Val Leu 
                245                 250                 255     


Asp Gly Asp Asp Leu Gly Pro Met Phe Leu Pro Cys Val Leu Val Pro 
            260                 265                 270         


Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln Ala Ala Ile Pro Glu 
        275                 280                 285             


Leu Arg Thr Pro Asp Leu Gly Ser Leu Cys Ser Gly Thr Asn Ser Trp 
    290                 295                 300                 


Cys Gln Gly Arg Ser Gly Val His Trp Ser Ser Pro Ala Trp Arg Cys 
305                 310                 315                 320 


Leu Phe Pro Arg Arg Leu His Gln Met 
                325                 


<210>  10069
<211>  719
<212>  PRT
<213>  Homo Sapiens

<400>  10069

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Cys 
            20                  25                  30          


Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile Val Ala Ile Asp Glu 
        35                  40                  45              


Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn Met Leu Ile Lys Gly 
    50                  55                  60                  


Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu Ser Leu Lys Asp Asn 
65                  70                  75                  80  


Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys Gln Met Leu Phe Leu 
                85                  90                  95      


Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro Pro Met Asn Ile His 
            100                 105                 110         


Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys Lys Val Gly Thr Ile 
        115                 120                 125             


Ile Tyr His Glu Val Arg Ile Val Val Arg Asp Arg Asn Asp Asn Ser 
    130                 135                 140                 


Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr Val Asn Glu Leu Thr 
145                 150                 155                 160 


Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser Gly Asp Asn Gly Ala 
                165                 170                 175     


Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile Glu Tyr Val Ile Gln 
            180                 185                 190         


Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr Phe Glu Ile Pro Leu 
        195                 200                 205             


Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg Leu Asn Tyr Glu Asp 
    210                 215                 220                 


Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn Asp Arg Ala Gln Asn 
225                 230                 235                 240 


Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu Thr Val Asp Val Leu 
                245                 250                 255     


Asp Gly Asp Asp Leu Gly Pro Met Phe Leu Pro Cys Val Leu Val Pro 
            260                 265                 270         


Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln Ala Ala Ile Pro Glu 
        275                 280                 285             


Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile Val Thr Pro Pro Ile 
    290                 295                 300                 


Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro Pro Ser Asp Arg Pro 
305                 310                 315                 320 


Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro Glu Asp Tyr Pro Arg 
                325                 330                 335     


Phe Phe His Met His Pro Arg Thr Ala Glu Leu Ser Leu Leu Glu Pro 
            340                 345                 350         


Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu Val Ile Lys Ala Glu 
        355                 360                 365             


Gln Asp Asn Gly His Pro Leu Pro Ala Phe Ala Gly Leu His Ile Glu 
    370                 375                 380                 


Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe Thr Met Pro Ser Tyr 
385                 390                 395                 400 


Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly Ala Thr Ile Ser Asp 
                405                 410                 415     


Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val Ala Leu Asp Lys Asp 
            420                 425                 430         


Ile Glu Asp Glu Glu Pro Lys Lys Ile Lys Lys Pro Lys Val Glu Ile 
        435                 440                 445             


Arg Glu Pro Ser Glu Glu Glu Glu Val Val Val Thr Ile Glu Lys Pro 
    450                 455                 460                 


Pro Ala Ala Glu Pro Thr Tyr Thr Thr Trp Lys Arg Ala Arg Ile Phe 
465                 470                 475                 480 


Pro Met Ile Phe Lys Lys Val Arg Gly Leu Ala Asp Lys Arg Gly Ile 
                485                 490                 495     


Val Asp Leu Glu Gly Glu Glu Trp Gln Arg Arg Leu Glu Glu Glu Asp 
            500                 505                 510         


Lys Asp Tyr Leu Lys Leu Thr Leu Asp Gln Glu Glu Ala Thr Glu Ser 
        515                 520                 525             


Thr Val Glu Ser Glu Glu Glu Ser Ser Ser Asp Tyr Thr Glu Tyr Ser 
    530                 535                 540                 


Glu Glu Glu Ser Glu Phe Ser Glu Ser Glu Thr Thr Glu Glu Glu Ser 
545                 550                 555                 560 


Glu Ser Glu Thr Pro Ser Glu Glu Glu Glu Ser Ser Thr Pro Glu Ser 
                565                 570                 575     


Glu Glu Ser Glu Ser Thr Glu Ser Glu Gly Glu Lys Ala Arg Lys Asn 
            580                 585                 590         


Ile Val Leu Ala Arg Arg Arg Pro Met Val Glu Glu Val Lys Glu Val 
        595                 600                 605             


Lys Gly Arg Lys Glu Glu Pro Gln Glu Glu Gln Lys Glu Pro Lys Met 
    610                 615                 620                 


Glu Glu Glu Glu His Ser Glu Glu Glu Glu Ser Gly Pro Ala Pro Val 
625                 630                 635                 640 


Glu Glu Ser Thr Asp Pro Glu Ala Gln Asp Ile Pro Glu Glu Gly Ser 
                645                 650                 655     


Ala Glu Ser Ala Ser Val Glu Gly Gly Val Glu Ser Glu Glu Glu Ser 
            660                 665                 670         


Glu Ser Gly Ser Ser Ser Ser Ser Ser Glu Ser Gln Ser Gly Gly Pro 
        675                 680                 685             


Trp Gly Tyr Gln Val Pro Ala Tyr Asp Arg Ser Lys Asn Ala Asn Gln 
    690                 695                 700                 


Lys Lys Ser Pro Gly Ala Asn Ser Glu Gly Tyr Asn Thr Ala Leu 
705                 710                 715                 


<210>  10070
<211>  1952
<212>  PRT
<213>  Homo Sapiens

<400>  10070

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Cys 
            20                  25                  30          


Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile Val Ala Ile Asp Glu 
        35                  40                  45              


Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn Met Leu Ile Lys Gly 
    50                  55                  60                  


Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu Ser Leu Lys Asp Asn 
65                  70                  75                  80  


Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys Gln Met Leu Phe Leu 
                85                  90                  95      


Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro Pro Met Asn Ile His 
            100                 105                 110         


Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys Lys Val Gly Thr Ile 
        115                 120                 125             


Ile Tyr His Glu Val Arg Ile Val Val Arg Asp Arg Asn Asp Asn Ser 
    130                 135                 140                 


Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr Val Asn Glu Leu Thr 
145                 150                 155                 160 


Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser Gly Asp Asn Gly Ala 
                165                 170                 175     


Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile Glu Tyr Val Ile Gln 
            180                 185                 190         


Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr Phe Glu Ile Pro Leu 
        195                 200                 205             


Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg Leu Asn Tyr Glu Asp 
    210                 215                 220                 


Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn Asp Arg Ala Gln Asn 
225                 230                 235                 240 


Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu Thr Val Asp Val Leu 
                245                 250                 255     


Asp Gly Asp Asp Leu Gly Pro Met Phe Leu Pro Cys Val Leu Val Pro 
            260                 265                 270         


Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln Ala Ala Ile Pro Glu 
        275                 280                 285             


Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile Val Thr Pro Pro Ile 
    290                 295                 300                 


Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro Pro Ser Asp Arg Pro 
305                 310                 315                 320 


Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro Glu Asp Tyr Pro Arg 
                325                 330                 335     


Phe Phe His Met His Pro Arg Thr Ala Glu Leu Ser Leu Leu Glu Pro 
            340                 345                 350         


Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu Val Ile Lys Ala Glu 
        355                 360                 365             


Gln Asp Asn Gly His Pro Leu Pro Ala Phe Ala Gly Leu His Ile Glu 
    370                 375                 380                 


Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe Thr Met Pro Ser Tyr 
385                 390                 395                 400 


Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly Ala Thr Ile Ser Asp 
                405                 410                 415     


Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val Ala Leu Asp Lys Asp 
            420                 425                 430         


Ile Glu Asp Thr Lys Asp Pro Glu Leu His Leu Phe Leu Asn Asp Tyr 
        435                 440                 445             


Thr Ser Val Phe Thr Val Thr Gln Thr Gly Ile Thr Arg Tyr Leu Thr 
    450                 455                 460                 


Leu Leu Gln Pro Val Asp Arg Glu Glu Gln Gln Thr Tyr Thr Phe Ser 
465                 470                 475                 480 


Ile Thr Ala Phe Asp Gly Val Gln Glu Ser Glu Pro Val Ile Val Asn 
                485                 490                 495     


Ile Gln Val Met Asp Ala Asn Asp Asn Thr Pro Thr Phe Pro Glu Ile 
            500                 505                 510         


Ser Tyr Asp Val Tyr Val Tyr Thr Asp Met Arg Pro Gly Asp Ser Val 
        515                 520                 525             


Ile Gln Leu Thr Ala Val Asp Ala Asp Glu Gly Ser Asn Gly Glu Ile 
    530                 535                 540                 


Thr Tyr Glu Ile Leu Val Gly Ala Gln Gly Asp Phe Ile Ile Asn Lys 
545                 550                 555                 560 


Thr Thr Gly Leu Ile Thr Ile Ala Pro Gly Val Glu Met Ile Val Gly 
                565                 570                 575     


Arg Thr Tyr Ala Leu Thr Val Gln Ala Ala Asp Asn Ala Pro Pro Ala 
            580                 585                 590         


Glu Arg Arg Asn Ser Ile Cys Thr Val Tyr Ile Glu Val Leu Pro Pro 
        595                 600                 605             


Asn Asn Gln Ser Pro Pro Arg Phe Pro Gln Leu Met Tyr Ser Leu Glu 
    610                 615                 620                 


Ile Ser Glu Ala Met Arg Val Gly Ala Val Leu Leu Asn Leu Gln Ala 
625                 630                 635                 640 


Thr Asp Arg Glu Gly Asp Ser Ile Thr Tyr Ala Ile Glu Asn Gly Asp 
                645                 650                 655     


Pro Gln Arg Val Phe Asn Leu Ser Glu Thr Thr Gly Ile Leu Thr Leu 
            660                 665                 670         


Gly Lys Ala Leu Asp Arg Glu Ser Thr Asp Arg Tyr Ile Leu Ile Ile 
        675                 680                 685             


Thr Ala Ser Asp Gly Arg Pro Asp Gly Thr Ser Thr Ala Thr Val Asn 
    690                 695                 700                 


Ile Val Val Thr Asp Val Asn Asp Asn Ala Pro Val Phe Asp Pro Tyr 
705                 710                 715                 720 


Leu Pro Arg Asn Leu Ser Val Val Glu Glu Glu Ala Asn Ala Phe Val 
                725                 730                 735     


Gly Gln Val Lys Ala Thr Asp Pro Asp Ala Gly Ile Asn Gly Gln Val 
            740                 745                 750         


His Tyr Ser Leu Gly Asn Phe Asn Asn Leu Phe Arg Ile Thr Ser Asn 
        755                 760                 765             


Gly Ser Ile Tyr Thr Ala Val Lys Leu Asn Arg Glu Val Arg Asp Tyr 
    770                 775                 780                 


Tyr Glu Leu Val Val Val Ala Thr Asp Gly Ala Val His Pro Arg His 
785                 790                 795                 800 


Ser Thr Leu Thr Leu Ala Ile Lys Val Leu Asp Ile Asp Asp Asn Ser 
                805                 810                 815     


Pro Val Phe Thr Asn Ser Thr Tyr Thr Val Leu Val Glu Glu Asn Leu 
            820                 825                 830         


Pro Ala Gly Thr Thr Ile Leu Gln Ile Glu Ala Lys Asp Val Asp Leu 
        835                 840                 845             


Gly Ala Asn Val Ser Tyr Arg Ile Arg Ser Pro Glu Val Lys His Phe 
    850                 855                 860                 


Phe Ala Leu His Pro Phe Thr Gly Glu Leu Ser Leu Leu Arg Ser Leu 
865                 870                 875                 880 


Asp Tyr Glu Ala Phe Pro Asp Gln Glu Ala Ser Ile Thr Phe Leu Val 
                885                 890                 895     


Glu Ala Phe Asp Ile Tyr Gly Thr Met Pro Pro Gly Ile Ala Thr Val 
            900                 905                 910         


Thr Val Ile Val Lys Asp Met Asn Asp Tyr Pro Pro Val Phe Ser Lys 
        915                 920                 925             


Arg Ile Tyr Lys Gly Met Val Ala Pro Asp Ala Val Lys Gly Thr Pro 
    930                 935                 940                 


Ile Thr Thr Val Tyr Ala Glu Asp Ala Asp Pro Pro Gly Leu Pro Ala 
945                 950                 955                 960 


Ser Arg Val Arg Tyr Arg Val Asp Asp Val Gln Phe Pro Tyr Pro Ala 
                965                 970                 975     


Ser Ile Phe Glu Val Glu Glu Asp Ser Gly Arg Val Ile Thr Arg Val 
            980                 985                 990         


Asn Leu Asn Glu Glu Pro Thr Thr  Ile Phe Lys Leu Val  Val Val Ala 
        995                 1000                 1005             


Phe Asp  Asp Gly Glu Pro Val  Met Ser Ser Ser Ala  Thr Val Lys 
    1010                 1015                 1020             


Ile Leu  Val Leu His Pro Gly  Glu Ile Pro Arg Phe  Thr Gln Glu 
    1025                 1030                 1035             


Glu Tyr  Arg Pro Pro Pro Val  Ser Glu Leu Ala Thr  Lys Gly Thr 
    1040                 1045                 1050             


Met Val  Gly Val Ile Ser Ala  Ala Ala Ile Asn Gln  Ser Ile Val 
    1055                 1060                 1065             


Tyr Ser  Ile Val Ser Gly Asn  Glu Glu Asp Thr Phe  Gly Ile Asn 
    1070                 1075                 1080             


Asn Ile  Thr Gly Val Ile Tyr  Val Asn Gly Pro Leu  Asp Tyr Glu 
    1085                 1090                 1095             


Thr Arg  Thr Ser Tyr Val Leu  Arg Val Gln Ala Asp  Ser Leu Glu 
    1100                 1105                 1110             


Val Val  Leu Ala Asn Leu Arg  Val Pro Ser Lys Ser  Asn Thr Ala 
    1115                 1120                 1125             


Lys Val  Tyr Ile Glu Ile Gln  Asp Glu Asn Asn His  Pro Pro Val 
    1130                 1135                 1140             


Phe Gln  Lys Lys Phe Tyr Ile  Gly Gly Val Ser Glu  Asp Ala Arg 
    1145                 1150                 1155             


Met Phe  Thr Ser Val Leu Arg  Val Lys Ala Thr Asp  Lys Asp Thr 
    1160                 1165                 1170             


Gly Asn  Tyr Ser Val Met Ala  Tyr Arg Leu Ile Ile  Pro Pro Ile 
    1175                 1180                 1185             


Lys Glu  Gly Lys Glu Gly Phe  Val Val Glu Thr Tyr  Thr Gly Leu 
    1190                 1195                 1200             


Ile Lys  Thr Ala Met Leu Phe  His Asn Met Arg Arg  Ser Tyr Phe 
    1205                 1210                 1215             


Lys Phe  Gln Val Ile Ala Thr  Asp Asp Tyr Gly Lys  Gly Leu Ser 
    1220                 1225                 1230             


Gly Lys  Ala Asp Val Leu Val  Ser Val Val Asn Gln  Leu Asp Met 
    1235                 1240                 1245             


Gln Val  Ile Val Ser Asn Val  Pro Pro Thr Leu Val  Glu Lys Lys 
    1250                 1255                 1260             


Ile Glu  Asp Leu Thr Glu Ile  Leu Asp Arg Tyr Val  Gln Glu Gln 
    1265                 1270                 1275             


Ile Pro  Gly Ala Lys Val Val  Val Glu Ser Ile Gly  Ala Arg Arg 
    1280                 1285                 1290             


His Gly  Asp Ala Phe Ser Leu  Glu Asp Tyr Thr Lys  Cys Asp Leu 
    1295                 1300                 1305             


Thr Val  Tyr Ala Ile Asp Pro  Gln Thr Asn Arg Ala  Ile Asp Arg 
    1310                 1315                 1320             


Asn Glu  Leu Phe Lys Phe Leu  Asp Gly Lys Leu Leu  Asp Ile Asn 
    1325                 1330                 1335             


Lys Asp  Phe Gln Pro Tyr Tyr  Gly Glu Gly Gly Arg  Ile Leu Glu 
    1340                 1345                 1350             


Ile Arg  Thr Pro Glu Ala Val  Thr Ser Ile Lys Lys  Arg Gly Glu 
    1355                 1360                 1365             


Ser Leu  Gly Tyr Thr Glu Gly  Ala Leu Leu Ala Leu  Ala Phe Ile 
    1370                 1375                 1380             


Ile Ile  Leu Cys Cys Ile Pro  Ala Ile Leu Val Val  Leu Val Ser 
    1385                 1390                 1395             


Tyr Arg  Gln Arg Gln Ala Glu  Cys Thr Lys Thr Ala  Arg Ile Gln 
    1400                 1405                 1410             


Ala Ala  Leu Pro Ala Ala Lys  Pro Ala Val Pro Ala  Pro Ala Pro 
    1415                 1420                 1425             


Val Ala  Ala Pro Pro Pro Pro  Pro Pro Pro Pro Pro  Gly Ala His 
    1430                 1435                 1440             


Leu Tyr  Glu Glu Leu Gly Asp  Ser Ser Ile Leu Phe  Leu Leu Tyr 
    1445                 1450                 1455             


His Phe  Gln Gln Ser Arg Gly  Asn Asn Ser Val Ser  Glu Asp Arg 
    1460                 1465                 1470             


Lys His  Gln Gln Val Val Met  Pro Phe Ser Ser Asn  Thr Ile Glu 
    1475                 1480                 1485             


Ala His  Lys Ser Ala His Val  Asp Gly Ser Leu Lys  Ser Asn Lys 
    1490                 1495                 1500             


Leu Lys  Ser Ala Arg Lys Phe  Thr Phe Leu Ser Asp  Glu Asp Asp 
    1505                 1510                 1515             


Leu Ser  Ala His Asn Pro Leu  Tyr Lys Glu Asn Ile  Ser Gln Val 
    1520                 1525                 1530             


Ser Thr  Asn Ser Asp Ile Ser  Gln Arg Thr Asp Phe  Val Asp Pro 
    1535                 1540                 1545             


Phe Ser  Pro Lys Ile Gln Ala  Lys Ser Lys Ser Leu  Arg Gly Pro 
    1550                 1555                 1560             


Arg Glu  Lys Ile Gln Arg Leu  Trp Ser Gln Ser Val  Ser Leu Pro 
    1565                 1570                 1575             


Arg Arg  Leu Met Arg Lys Val  Pro Asn Arg Pro Glu  Ile Ile Asp 
    1580                 1585                 1590             


Leu Gln  Gln Trp Gln Gly Thr  Arg Gln Lys Ala Glu  Asn Glu Asn 
    1595                 1600                 1605             


Thr Gly  Ile Cys Thr Asn Lys  Arg Gly Ser Ser Asn  Pro Leu Leu 
    1610                 1615                 1620             


Thr Thr  Glu Glu Ala Asn Leu  Thr Glu Lys Glu Glu  Ile Arg Gln 
    1625                 1630                 1635             


Gly Glu  Thr Leu Met Ile Glu  Gly Thr Glu Gln Leu  Lys Ser Leu 
    1640                 1645                 1650             


Ser Ser  Asp Ser Ser Phe Cys  Phe Pro Arg Pro His  Phe Ser Phe 
    1655                 1660                 1665             


Ser Thr  Leu Pro Thr Val Ser  Arg Thr Val Glu Leu  Lys Ser Glu 
    1670                 1675                 1680             


Pro Asn  Val Ile Ser Ser Pro  Ala Glu Cys Ser Leu  Glu Leu Ser 
    1685                 1690                 1695             


Pro Ser  Arg Pro Cys Val Leu  His Ser Ser Leu Ser  Arg Arg Glu 
    1700                 1705                 1710             


Thr Pro  Ile Cys Met Leu Pro  Ile Glu Thr Glu Arg  Asn Ile Phe 
    1715                 1720                 1725             


Glu Asn  Phe Ala His Pro Pro  Asn Ile Ser Pro Ser  Ala Cys Pro 
    1730                 1735                 1740             


Leu Pro  Pro Pro Pro Pro Ile  Ser Pro Pro Ser Pro  Pro Pro Ala 
    1745                 1750                 1755             


Pro Ala  Pro Leu Ala Pro Pro  Pro Asp Ile Ser Pro  Phe Ser Leu 
    1760                 1765                 1770             


Phe Cys  Pro Pro Pro Ser Pro  Pro Ser Ile Pro Leu  Pro Leu Pro 
    1775                 1780                 1785             


Pro Pro  Thr Phe Phe Pro Leu  Ser Val Ser Thr Ser  Gly Pro Pro 
    1790                 1795                 1800             


Thr Pro  Pro Leu Leu Pro Pro  Phe Pro Thr Pro Leu  Pro Pro Pro 
    1805                 1810                 1815             


Pro Pro  Ser Ile Pro Cys Pro  Pro Pro Pro Ser Ala  Ser Phe Leu 
    1820                 1825                 1830             


Ser Thr  Glu Cys Val Cys Ile  Thr Gly Val Lys Cys  Thr Thr Asn 
    1835                 1840                 1845             


Leu Met  Pro Ala Glu Lys Ile  Lys Ser Ser Met Thr  Gln Leu Ser 
    1850                 1855                 1860             


Thr Thr  Thr Val Cys Lys Thr  Asp Pro Gln Arg Glu  Pro Lys Gly 
    1865                 1870                 1875             


Ile Leu  Arg His Val Lys Asn  Leu Ala Glu Leu Glu  Lys Ser Val 
    1880                 1885                 1890             


Ala Asn  Met Tyr Ser Gln Ile  Glu Lys Asn Tyr Leu  Arg Thr Asn 
    1895                 1900                 1905             


Val Ser  Glu Leu Gln Thr Met  Cys Pro Ser Glu Val  Thr Asn Met 
    1910                 1915                 1920             


Glu Ile  Thr Ser Glu Gln Asn  Lys Gly Ser Leu Asn  Asn Ile Val 
    1925                 1930                 1935             


Glu Gly  Thr Glu Lys Gln Ser  His Ser Gln Ser Thr  Ser Leu 
    1940                 1945                 1950         


<210>  10071
<211>  1539
<212>  PRT
<213>  Homo Sapiens

<400>  10071

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Cys 
            20                  25                  30          


Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile Val Ala Ile Asp Glu 
        35                  40                  45              


Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn Met Leu Ile Lys Gly 
    50                  55                  60                  


Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu Ser Leu Lys Asp Asn 
65                  70                  75                  80  


Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys Gln Met Leu Phe Leu 
                85                  90                  95      


Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro Pro Met Asn Ile His 
            100                 105                 110         


Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys Lys Val Gly Thr Ile 
        115                 120                 125             


Ile Tyr His Glu Val Arg Ile Val Val Arg Asp Arg Asn Asp Asn Ser 
    130                 135                 140                 


Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr Val Asn Glu Leu Thr 
145                 150                 155                 160 


Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser Gly Asp Asn Gly Ala 
                165                 170                 175     


Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile Glu Tyr Val Ile Gln 
            180                 185                 190         


Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr Phe Glu Ile Pro Leu 
        195                 200                 205             


Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg Leu Asn Tyr Glu Asp 
    210                 215                 220                 


Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn Asp Arg Ala Gln Asn 
225                 230                 235                 240 


Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu Thr Val Asp Val Leu 
                245                 250                 255     


Asp Gly Asp Asp Leu Gly Pro Met Phe Leu Pro Cys Val Leu Val Pro 
            260                 265                 270         


Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln Ala Ala Ile Pro Glu 
        275                 280                 285             


Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile Val Thr Pro Pro Ile 
    290                 295                 300                 


Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro Pro Ser Asp Arg Pro 
305                 310                 315                 320 


Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro Glu Asp Tyr Pro Arg 
                325                 330                 335     


Phe Phe His Met His Pro Arg Thr Ala Glu Leu Ser Leu Leu Glu Pro 
            340                 345                 350         


Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu Val Ile Lys Ala Glu 
        355                 360                 365             


Gln Asp Asn Gly His Pro Leu Pro Ala Phe Ala Gly Leu His Ile Glu 
    370                 375                 380                 


Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe Thr Met Pro Ser Tyr 
385                 390                 395                 400 


Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly Ala Thr Ile Ser Asp 
                405                 410                 415     


Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val Ala Leu Asp Lys Asp 
            420                 425                 430         


Ile Glu Asp Thr Lys Asp Pro Glu Leu His Leu Phe Leu Asn Asp Tyr 
        435                 440                 445             


Thr Ser Val Phe Thr Val Thr Gln Thr Gly Ile Thr Arg Tyr Leu Thr 
    450                 455                 460                 


Leu Leu Gln Pro Val Asp Arg Glu Glu Gln Gln Thr Tyr Thr Phe Ser 
465                 470                 475                 480 


Ile Thr Ala Phe Asp Gly Val Gln Glu Ser Glu Pro Val Ile Val Asn 
                485                 490                 495     


Ile Gln Val Met Asp Ala Asn Asp Asn Thr Pro Thr Phe Pro Glu Ile 
            500                 505                 510         


Ser Tyr Asp Val Tyr Val Tyr Thr Asp Met Arg Pro Gly Asp Ser Val 
        515                 520                 525             


Ile Gln Leu Thr Ala Val Asp Ala Asp Glu Gly Ser Asn Gly Glu Ile 
    530                 535                 540                 


Thr Tyr Glu Ile Leu Val Gly Ala Gln Gly Asp Phe Ile Ile Asn Lys 
545                 550                 555                 560 


Thr Thr Gly Leu Ile Thr Ile Ala Pro Gly Val Glu Met Ile Val Gly 
                565                 570                 575     


Arg Thr Tyr Ala Leu Thr Val Gln Ala Ala Asp Asn Ala Pro Pro Ala 
            580                 585                 590         


Glu Arg Arg Asn Ser Ile Cys Thr Val Tyr Ile Glu Val Leu Pro Pro 
        595                 600                 605             


Asn Asn Gln Ser Pro Pro Arg Phe Pro Gln Leu Met Tyr Ser Leu Glu 
    610                 615                 620                 


Ile Ser Glu Ala Met Arg Val Gly Ala Val Leu Leu Asn Leu Gln Ala 
625                 630                 635                 640 


Thr Asp Arg Glu Gly Asp Ser Ile Thr Tyr Ala Ile Glu Asn Gly Asp 
                645                 650                 655     


Pro Gln Arg Val Phe Asn Leu Ser Glu Thr Thr Gly Ile Leu Thr Leu 
            660                 665                 670         


Gly Lys Ala Leu Asp Arg Glu Ser Thr Asp Arg Tyr Ile Leu Ile Ile 
        675                 680                 685             


Thr Ala Ser Asp Gly Arg Pro Asp Gly Thr Ser Thr Ala Thr Val Asn 
    690                 695                 700                 


Ile Val Val Thr Asp Val Asn Asp Asn Ala Pro Val Phe Asp Pro Tyr 
705                 710                 715                 720 


Leu Pro Arg Asn Leu Ser Val Val Glu Glu Glu Ala Asn Ala Phe Val 
                725                 730                 735     


Gly Gln Val Lys Ala Thr Asp Pro Asp Ala Gly Ile Asn Gly Gln Val 
            740                 745                 750         


His Tyr Ser Leu Gly Asn Phe Asn Asn Leu Phe Arg Ile Thr Ser Asn 
        755                 760                 765             


Gly Ser Ile Tyr Thr Ala Val Lys Leu Asn Arg Glu Val Arg Asp Tyr 
    770                 775                 780                 


Tyr Glu Leu Val Val Val Ala Thr Asp Gly Ala Val His Pro Arg His 
785                 790                 795                 800 


Ser Thr Leu Thr Leu Ala Ile Lys Val Leu Asp Ile Asp Asp Asn Ser 
                805                 810                 815     


Pro Val Phe Thr Asn Ser Thr Tyr Thr Val Leu Val Glu Glu Asn Leu 
            820                 825                 830         


Pro Ala Gly Thr Thr Ile Leu Gln Ile Glu Ala Lys Asp Val Asp Leu 
        835                 840                 845             


Gly Ala Asn Val Ser Tyr Arg Ile Arg Ser Pro Glu Val Lys His Phe 
    850                 855                 860                 


Phe Ala Leu His Pro Phe Thr Gly Glu Leu Ser Leu Leu Arg Ser Leu 
865                 870                 875                 880 


Asp Tyr Glu Ala Phe Pro Asp Gln Glu Ala Ser Ile Thr Phe Leu Val 
                885                 890                 895     


Glu Ala Phe Asp Ile Tyr Gly Thr Met Pro Pro Gly Ile Ala Thr Val 
            900                 905                 910         


Thr Val Ile Val Lys Asp Met Asn Asp Tyr Pro Pro Val Phe Ser Lys 
        915                 920                 925             


Arg Ile Tyr Lys Gly Met Val Ala Pro Asp Ala Val Lys Gly Thr Pro 
    930                 935                 940                 


Ile Thr Thr Val Tyr Ala Glu Asp Ala Asp Pro Pro Gly Leu Pro Ala 
945                 950                 955                 960 


Ser Arg Val Arg Tyr Arg Val Asp Asp Val Gln Phe Pro Tyr Pro Ala 
                965                 970                 975     


Ser Ile Phe Glu Val Glu Glu Asp Ser Gly Arg Val Ile Thr Arg Val 
            980                 985                 990         


Asn Leu Asn Glu Glu Pro Thr Thr  Ile Phe Lys Leu Val  Val Val Ala 
        995                 1000                 1005             


Phe Asp  Asp Gly Glu Pro Val  Met Ser Ser Ser Ala  Thr Val Lys 
    1010                 1015                 1020             


Ile Leu  Val Leu His Pro Gly  Glu Ile Pro Arg Phe  Thr Gln Glu 
    1025                 1030                 1035             


Glu Tyr  Arg Pro Pro Pro Val  Ser Glu Leu Ala Thr  Lys Gly Thr 
    1040                 1045                 1050             


Met Val  Gly Val Ile Ser Ala  Ala Ala Ile Asn Gln  Ser Ile Val 
    1055                 1060                 1065             


Tyr Ser  Ile Val Ser Gly Asn  Glu Glu Asp Thr Phe  Gly Ile Asn 
    1070                 1075                 1080             


Asn Ile  Thr Gly Val Ile Tyr  Val Asn Gly Pro Leu  Asp Tyr Glu 
    1085                 1090                 1095             


Thr Arg  Thr Ser Tyr Val Leu  Arg Val Gln Ala Asp  Ser Leu Glu 
    1100                 1105                 1110             


Val Val  Leu Ala Asn Leu Arg  Val Pro Ser Lys Ser  Asn Thr Ala 
    1115                 1120                 1125             


Lys Val  Tyr Ile Glu Ile Gln  Asp Glu Asn Asn His  Pro Pro Val 
    1130                 1135                 1140             


Phe Gln  Lys Lys Phe Tyr Ile  Gly Gly Val Ser Glu  Asp Ala Arg 
    1145                 1150                 1155             


Met Phe  Thr Ser Val Leu Arg  Val Lys Ala Thr Asp  Lys Asp Thr 
    1160                 1165                 1170             


Gly Asn  Tyr Ser Val Met Ala  Tyr Arg Leu Ile Ile  Pro Pro Ile 
    1175                 1180                 1185             


Lys Glu  Gly Lys Glu Gly Phe  Val Val Glu Thr Tyr  Thr Gly Leu 
    1190                 1195                 1200             


Ile Lys  Thr Ala Met Leu Phe  His Asn Met Arg Arg  Ser Tyr Phe 
    1205                 1210                 1215             


Lys Phe  Gln Val Ile Ala Thr  Asp Asp Tyr Gly Lys  Gly Leu Ser 
    1220                 1225                 1230             


Gly Lys  Ala Asp Val Leu Val  Ser Val Val Asn Gln  Leu Asp Met 
    1235                 1240                 1245             


Gln Val  Ile Val Ser Asn Val  Pro Pro Thr Leu Val  Glu Lys Lys 
    1250                 1255                 1260             


Ile Glu  Asp Leu Thr Glu Ile  Leu Asp Arg Tyr Val  Gln Glu Gln 
    1265                 1270                 1275             


Ile Pro  Gly Ala Lys Val Val  Val Glu Ser Ile Gly  Ala Arg Arg 
    1280                 1285                 1290             


His Gly  Asp Ala Phe Ser Leu  Glu Asp Tyr Thr Lys  Cys Asp Leu 
    1295                 1300                 1305             


Thr Val  Tyr Ala Ile Asp Pro  Gln Thr Asn Arg Ala  Ile Asp Arg 
    1310                 1315                 1320             


Asn Glu  Leu Phe Lys Phe Leu  Asp Gly Lys Leu Leu  Asp Ile Asn 
    1325                 1330                 1335             


Lys Asp  Phe Gln Pro Tyr Tyr  Gly Glu Gly Gly Arg  Ile Leu Glu 
    1340                 1345                 1350             


Ile Arg  Thr Pro Glu Ala Val  Thr Ser Ile Lys Lys  Arg Gly Glu 
    1355                 1360                 1365             


Ser Leu  Gly Tyr Thr Glu Gly  Ala Leu Leu Ala Leu  Ala Phe Ile 
    1370                 1375                 1380             


Ile Ile  Leu Cys Cys Ile Pro  Ala Ile Leu Val Val  Leu Val Ser 
    1385                 1390                 1395             


Tyr Arg  Gln Phe Lys Val Arg  Gln Ala Glu Cys Thr  Lys Thr Ala 
    1400                 1405                 1410             


Arg Ile  Gln Ala Ala Leu Pro  Ala Ala Lys Pro Ala  Val Pro Ala 
    1415                 1420                 1425             


Pro Ala  Pro Val Ala Ala Pro  Pro Pro Pro Pro Pro  Pro Pro Pro 
    1430                 1435                 1440             


Gly Ala  His Leu Tyr Glu Glu  Leu Gly Asp Ser Ser  Met His Lys 
    1445                 1450                 1455             


Asn Tyr  Pro Trp Ser Leu Glu  Leu Ile Leu Ala Arg  Asn Met Asp 
    1460                 1465                 1470             


Lys Ile  Ile Thr Val Met Ser  Met Gly Met Lys Cys  Leu Asn Met 
    1475                 1480                 1485             


Gly Val  Ala Val Asp Cys Tyr  His Gln Leu Asp Arg  Arg Asn Met 
    1490                 1495                 1500             


Val Arg  Trp Leu Val Lys Leu  Arg Lys Asn Met Arg  Arg Lys Arg 
    1505                 1510                 1515             


Lys Ser  Gln Arg Lys Leu Lys  Asn Gln Arg Leu Lys  Leu Glu Ser 
    1520                 1525                 1530             


Leu Val  Arg Arg Lys Lys 
    1535                 


<210>  10072
<211>  1675
<212>  PRT
<213>  Homo Sapiens

<400>  10072

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Cys 
            20                  25                  30          


Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile Val Ala Ile Asp Glu 
        35                  40                  45              


Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn Met Leu Ile Lys Gly 
    50                  55                  60                  


Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu Ser Leu Lys Asp Asn 
65                  70                  75                  80  


Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys Gln Met Leu Phe Leu 
                85                  90                  95      


Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro Pro Met Asn Ile His 
            100                 105                 110         


Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys Lys Val Gly Thr Ile 
        115                 120                 125             


Ile Tyr His Glu Val Arg Ile Val Val Arg Asp Arg Asn Asp Asn Ser 
    130                 135                 140                 


Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr Val Asn Glu Leu Thr 
145                 150                 155                 160 


Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser Gly Asp Asn Gly Ala 
                165                 170                 175     


Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile Glu Tyr Val Ile Gln 
            180                 185                 190         


Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr Phe Glu Ile Pro Leu 
        195                 200                 205             


Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg Leu Asn Tyr Glu Asp 
    210                 215                 220                 


Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn Asp Arg Ala Gln Asn 
225                 230                 235                 240 


Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu Thr Val Asp Val Leu 
                245                 250                 255     


Asp Gly Asp Asp Leu Gly Pro Met Phe Leu Pro Cys Val Leu Val Pro 
            260                 265                 270         


Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln Ala Ala Ile Pro Glu 
        275                 280                 285             


Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile Val Thr Pro Pro Ile 
    290                 295                 300                 


Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro Pro Ser Asp Arg Pro 
305                 310                 315                 320 


Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro Glu Asp Tyr Pro Arg 
                325                 330                 335     


Phe Phe His Met His Pro Arg Thr Ala Glu Leu Ser Leu Leu Glu Pro 
            340                 345                 350         


Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu Val Ile Lys Ala Glu 
        355                 360                 365             


Gln Asp Asn Gly His Pro Leu Pro Ala Phe Ala Gly Leu His Ile Glu 
    370                 375                 380                 


Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe Thr Met Pro Ser Tyr 
385                 390                 395                 400 


Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly Ala Thr Ile Ser Asp 
                405                 410                 415     


Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val Ala Leu Asp Lys Asp 
            420                 425                 430         


Ile Glu Asp Thr Lys Asp Pro Glu Leu His Leu Phe Leu Asn Asp Tyr 
        435                 440                 445             


Thr Ser Val Phe Thr Val Thr Gln Thr Gly Ile Thr Arg Tyr Leu Thr 
    450                 455                 460                 


Leu Leu Gln Pro Val Asp Arg Glu Glu Gln Gln Thr Tyr Thr Phe Ser 
465                 470                 475                 480 


Ile Thr Ala Phe Asp Gly Val Gln Glu Ser Glu Pro Val Ile Val Asn 
                485                 490                 495     


Ile Gln Val Met Asp Ala Asn Asp Asn Thr Pro Thr Phe Pro Glu Ile 
            500                 505                 510         


Ser Tyr Asp Val Tyr Val Tyr Thr Asp Met Arg Pro Gly Asp Ser Val 
        515                 520                 525             


Ile Gln Leu Thr Ala Val Asp Ala Asp Glu Gly Ser Asn Gly Glu Ile 
    530                 535                 540                 


Thr Tyr Glu Ile Leu Val Gly Ala Gln Gly Asp Phe Ile Ile Asn Lys 
545                 550                 555                 560 


Thr Thr Gly Leu Ile Thr Ile Ala Pro Gly Val Glu Met Ile Val Gly 
                565                 570                 575     


Arg Thr Tyr Ala Leu Thr Val Gln Ala Ala Asp Asn Ala Pro Pro Ala 
            580                 585                 590         


Glu Arg Arg Asn Ser Ile Cys Thr Val Tyr Ile Glu Val Leu Pro Pro 
        595                 600                 605             


Asn Asn Gln Ser Pro Pro Arg Phe Pro Gln Leu Met Tyr Ser Leu Glu 
    610                 615                 620                 


Ile Ser Glu Ala Met Arg Val Gly Ala Val Leu Leu Asn Leu Gln Ala 
625                 630                 635                 640 


Thr Asp Arg Glu Gly Asp Ser Ile Thr Tyr Ala Ile Glu Asn Gly Asp 
                645                 650                 655     


Pro Gln Arg Val Phe Asn Leu Ser Glu Thr Thr Gly Ile Leu Thr Leu 
            660                 665                 670         


Gly Lys Ala Leu Asp Arg Glu Ser Thr Asp Arg Tyr Ile Leu Ile Ile 
        675                 680                 685             


Thr Ala Ser Asp Gly Arg Pro Asp Gly Thr Ser Thr Ala Thr Val Asn 
    690                 695                 700                 


Ile Val Val Thr Asp Val Asn Asp Asn Ala Pro Val Phe Asp Pro Tyr 
705                 710                 715                 720 


Leu Pro Arg Asn Leu Ser Val Val Glu Glu Glu Ala Asn Ala Phe Val 
                725                 730                 735     


Gly Gln Val Lys Ala Thr Asp Pro Asp Ala Gly Ile Asn Gly Gln Val 
            740                 745                 750         


His Tyr Ser Leu Gly Asn Phe Asn Asn Leu Phe Arg Ile Thr Ser Asn 
        755                 760                 765             


Gly Ser Ile Tyr Thr Ala Val Lys Leu Asn Arg Glu Val Arg Asp Tyr 
    770                 775                 780                 


Tyr Glu Leu Val Val Val Ala Thr Asp Gly Ala Val His Pro Arg His 
785                 790                 795                 800 


Ser Thr Leu Thr Leu Ala Ile Lys Val Leu Asp Ile Asp Asp Asn Ser 
                805                 810                 815     


Pro Val Phe Thr Asn Ser Thr Tyr Thr Val Leu Val Glu Glu Asn Leu 
            820                 825                 830         


Pro Ala Gly Thr Thr Ile Leu Gln Ile Glu Ala Lys Asp Val Asp Leu 
        835                 840                 845             


Gly Ala Asn Val Ser Tyr Arg Ile Arg Ser Pro Glu Val Lys His Phe 
    850                 855                 860                 


Phe Ala Leu His Pro Phe Thr Gly Glu Leu Ser Leu Leu Arg Ser Leu 
865                 870                 875                 880 


Asp Tyr Glu Ala Phe Pro Asp Gln Glu Ala Ser Ile Thr Phe Leu Val 
                885                 890                 895     


Glu Ala Phe Asp Ile Tyr Gly Thr Met Pro Pro Gly Ile Ala Thr Val 
            900                 905                 910         


Thr Val Ile Val Lys Asp Met Asn Asp Tyr Pro Pro Val Phe Ser Lys 
        915                 920                 925             


Arg Ile Tyr Lys Gly Met Val Ala Pro Asp Ala Val Lys Gly Thr Pro 
    930                 935                 940                 


Ile Thr Thr Val Tyr Ala Glu Asp Ala Asp Pro Pro Gly Leu Pro Ala 
945                 950                 955                 960 


Ser Arg Val Arg Tyr Arg Val Asp Asp Val Gln Phe Pro Tyr Pro Ala 
                965                 970                 975     


Ser Ile Phe Glu Val Glu Glu Asp Ser Gly Arg Val Ile Thr Arg Val 
            980                 985                 990         


Asn Leu Asn Glu Glu Pro Thr Thr  Ile Phe Lys Leu Val  Val Val Ala 
        995                 1000                 1005             


Phe Asp  Asp Gly Glu Pro Val  Met Ser Ser Ser Ala  Thr Val Lys 
    1010                 1015                 1020             


Ile Leu  Val Leu His Pro Gly  Glu Ile Pro Arg Phe  Thr Gln Glu 
    1025                 1030                 1035             


Glu Tyr  Arg Pro Pro Pro Val  Ser Glu Leu Ala Thr  Lys Gly Thr 
    1040                 1045                 1050             


Met Val  Gly Val Ile Ser Ala  Ala Ala Ile Asn Gln  Ser Ile Val 
    1055                 1060                 1065             


Tyr Ser  Ile Val Ser Gly Asn  Glu Glu Asp Thr Phe  Gly Ile Asn 
    1070                 1075                 1080             


Asn Ile  Thr Gly Val Ile Tyr  Val Asn Gly Pro Leu  Asp Tyr Glu 
    1085                 1090                 1095             


Thr Arg  Thr Ser Tyr Val Leu  Arg Val Gln Ala Asp  Ser Leu Glu 
    1100                 1105                 1110             


Val Val  Leu Ala Asn Leu Arg  Val Pro Ser Lys Ser  Asn Thr Ala 
    1115                 1120                 1125             


Lys Val  Tyr Ile Glu Ile Gln  Asp Glu Asn Asn His  Pro Pro Val 
    1130                 1135                 1140             


Phe Gln  Lys Lys Phe Tyr Ile  Gly Gly Val Ser Glu  Asp Ala Arg 
    1145                 1150                 1155             


Met Phe  Thr Ser Val Leu Arg  Val Lys Ala Thr Asp  Lys Asp Thr 
    1160                 1165                 1170             


Gly Asn  Tyr Ser Val Met Ala  Tyr Arg Leu Ile Ile  Pro Pro Ile 
    1175                 1180                 1185             


Lys Glu  Gly Lys Glu Gly Phe  Val Val Glu Thr Tyr  Thr Gly Leu 
    1190                 1195                 1200             


Ile Lys  Thr Ala Met Leu Phe  His Asn Met Arg Arg  Ser Tyr Phe 
    1205                 1210                 1215             


Lys Phe  Gln Val Ile Ala Thr  Asp Asp Tyr Gly Lys  Gly Leu Ser 
    1220                 1225                 1230             


Gly Lys  Ala Asp Val Leu Val  Ser Val Val Asn Gln  Leu Asp Met 
    1235                 1240                 1245             


Gln Val  Ile Val Ser Asn Val  Pro Pro Thr Leu Val  Glu Lys Lys 
    1250                 1255                 1260             


Ile Glu  Asp Leu Thr Glu Ile  Leu Asp Arg Tyr Val  Gln Glu Gln 
    1265                 1270                 1275             


Ile Pro  Gly Ala Lys Val Val  Val Glu Ser Ile Gly  Ala Arg Arg 
    1280                 1285                 1290             


His Gly  Asp Ala Phe Ser Leu  Glu Asp Tyr Thr Lys  Cys Asp Leu 
    1295                 1300                 1305             


Thr Val  Tyr Ala Ile Asp Pro  Gln Thr Asn Arg Ala  Ile Asp Arg 
    1310                 1315                 1320             


Asn Glu  Leu Phe Lys Phe Leu  Asp Gly Lys Leu Leu  Asp Ile Asn 
    1325                 1330                 1335             


Lys Asp  Phe Gln Pro Tyr Tyr  Gly Glu Gly Gly Arg  Ile Leu Glu 
    1340                 1345                 1350             


Ile Arg  Thr Pro Glu Ala Val  Thr Ser Ile Lys Lys  Arg Gly Glu 
    1355                 1360                 1365             


Ser Leu  Gly Tyr Thr Glu Gly  Ala Leu Leu Ala Leu  Ala Phe Ile 
    1370                 1375                 1380             


Ile Ile  Leu Cys Cys Ile Pro  Ala Ile Leu Val Val  Leu Val Ser 
    1385                 1390                 1395             


Tyr Arg  Gln Phe Lys Val Arg  Gln Ala Glu Cys Thr  Lys Thr Ala 
    1400                 1405                 1410             


Arg Ile  Gln Ala Ala Leu Pro  Ala Ala Lys Pro Ala  Val Pro Ala 
    1415                 1420                 1425             


Pro Ala  Pro Val Ala Ala Pro  Pro Pro Pro Pro Pro  Pro Pro Pro 
    1430                 1435                 1440             


Gly Ala  His Leu Tyr Glu Glu  Leu Gly Asp Ser Ser  Met Tyr Glu 
    1445                 1450                 1455             


Met Pro  Gln Tyr Gly Ser Arg  Arg Arg Leu Leu Pro  Pro Ala Gly 
    1460                 1465                 1470             


Gln Glu  Glu Tyr Gly Glu Val  Val Gly Glu Ala Glu  Glu Glu Tyr 
    1475                 1480                 1485             


Glu Glu  Glu Glu Trp Ala Arg  Lys Arg Met Ile Lys  Leu Val Val 
    1490                 1495                 1500             


Asp Arg  Glu Tyr Glu Thr Ser  Ser Thr Gly Glu Asp  Ser Ala Pro 
    1505                 1510                 1515             


Glu Cys  Gln Arg Asn Arg Leu  His His Pro Ser Ile  His Ser Asn 
    1520                 1525                 1530             


Ile Asn  Gly Asn Ile Tyr Ile  Ala Gln Asn Gly Ser  Val Val Arg 
    1535                 1540                 1545             


Thr Arg  Arg Ala Cys Leu Thr  Asp Asn Leu Lys Val  Ala Ser Pro 
    1550                 1555                 1560             


Val Arg  Leu Gly Gly Pro Phe  Lys Lys Leu Asp Lys  Leu Ala Val 
    1565                 1570                 1575             


Thr His  Glu Glu Asn Val Pro  Leu Asn Thr Leu Ser  Lys Gly Pro 
    1580                 1585                 1590             


Phe Ser  Thr Glu Lys Met Asn  Ala Arg Pro Thr Leu  Val Thr Phe 
    1595                 1600                 1605             


Ala Pro  Cys Pro Val Gly Thr  Asp Asn Thr Ala Val  Lys Pro Leu 
    1610                 1615                 1620             


Arg Asn  Arg Leu Lys Ser Thr  Val Glu Gln Glu Ser  Met Ile Asp 
    1625                 1630                 1635             


Ser Lys  Asn Ile Lys Glu Ala  Leu Glu Phe His Ser  Asp His Thr 
    1640                 1645                 1650             


Gln Ser  Asp Asp Glu Glu Leu  Trp Met Gly Pro Trp  Asn Asn Leu 
    1655                 1660                 1665             


His Ile  Pro Met Thr Lys Leu  
    1670                 1675 


<210>  10073
<211>  1740
<212>  PRT
<213>  Homo Sapiens

<400>  10073

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Cys 
            20                  25                  30          


Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile Val Ala Ile Asp Glu 
        35                  40                  45              


Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn Met Leu Ile Lys Gly 
    50                  55                  60                  


Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu Ser Leu Lys Asp Asn 
65                  70                  75                  80  


Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys Gln Met Leu Phe Leu 
                85                  90                  95      


Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro Pro Met Asn Ile His 
            100                 105                 110         


Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys Lys Val Gly Thr Ile 
        115                 120                 125             


Ile Tyr His Glu Val Arg Ile Val Val Arg Asp Arg Asn Asp Asn Ser 
    130                 135                 140                 


Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr Val Asn Glu Leu Thr 
145                 150                 155                 160 


Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser Gly Asp Asn Gly Ala 
                165                 170                 175     


Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile Glu Tyr Val Ile Gln 
            180                 185                 190         


Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr Phe Glu Ile Pro Leu 
        195                 200                 205             


Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg Leu Asn Tyr Glu Asp 
    210                 215                 220                 


Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn Asp Arg Ala Gln Asn 
225                 230                 235                 240 


Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu Thr Val Asp Val Leu 
                245                 250                 255     


Asp Gly Asp Asp Leu Gly Pro Met Phe Leu Pro Cys Val Leu Val Pro 
            260                 265                 270         


Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln Ala Ala Ile Pro Glu 
        275                 280                 285             


Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile Val Thr Pro Pro Ile 
    290                 295                 300                 


Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro Pro Ser Asp Arg Pro 
305                 310                 315                 320 


Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro Glu Asp Tyr Pro Arg 
                325                 330                 335     


Phe Phe His Met His Pro Arg Thr Ala Glu Leu Ser Leu Leu Glu Pro 
            340                 345                 350         


Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu Val Ile Lys Ala Glu 
        355                 360                 365             


Gln Asp Asn Gly His Pro Leu Pro Ala Phe Ala Gly Leu His Ile Glu 
    370                 375                 380                 


Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe Thr Met Pro Ser Tyr 
385                 390                 395                 400 


Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly Ala Thr Ile Ser Asp 
                405                 410                 415     


Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val Ala Leu Asp Lys Asp 
            420                 425                 430         


Ile Glu Asp Thr Lys Asp Pro Glu Leu His Leu Phe Leu Asn Asp Tyr 
        435                 440                 445             


Thr Ser Val Phe Thr Val Thr Gln Thr Gly Ile Thr Arg Tyr Leu Thr 
    450                 455                 460                 


Leu Leu Gln Pro Val Asp Arg Glu Glu Gln Gln Thr Tyr Thr Phe Ser 
465                 470                 475                 480 


Ile Thr Ala Phe Asp Gly Val Gln Glu Ser Glu Pro Val Ile Val Asn 
                485                 490                 495     


Ile Gln Val Met Asp Ala Asn Asp Asn Thr Pro Thr Phe Pro Glu Ile 
            500                 505                 510         


Ser Tyr Asp Val Tyr Val Tyr Thr Asp Met Arg Pro Gly Asp Ser Val 
        515                 520                 525             


Ile Gln Leu Thr Ala Val Asp Ala Asp Glu Gly Ser Asn Gly Glu Ile 
    530                 535                 540                 


Thr Tyr Glu Ile Leu Val Gly Ala Gln Gly Asp Phe Ile Ile Asn Lys 
545                 550                 555                 560 


Thr Thr Gly Leu Ile Thr Ile Ala Pro Gly Val Glu Met Ile Val Gly 
                565                 570                 575     


Arg Thr Tyr Ala Leu Thr Val Gln Ala Ala Asp Asn Ala Pro Pro Ala 
            580                 585                 590         


Glu Arg Arg Asn Ser Ile Cys Thr Val Tyr Ile Glu Val Leu Pro Pro 
        595                 600                 605             


Asn Asn Gln Ser Pro Pro Arg Phe Pro Gln Leu Met Tyr Ser Leu Glu 
    610                 615                 620                 


Ile Ser Glu Ala Met Arg Val Gly Ala Val Leu Leu Asn Leu Gln Ala 
625                 630                 635                 640 


Thr Asp Arg Glu Gly Asp Ser Ile Thr Tyr Ala Ile Glu Asn Gly Asp 
                645                 650                 655     


Pro Gln Arg Val Phe Asn Leu Ser Glu Thr Thr Gly Ile Leu Thr Leu 
            660                 665                 670         


Gly Lys Ala Leu Asp Arg Glu Ser Thr Asp Arg Tyr Ile Leu Ile Ile 
        675                 680                 685             


Thr Ala Ser Asp Gly Arg Pro Asp Gly Thr Ser Thr Ala Thr Val Asn 
    690                 695                 700                 


Ile Val Val Thr Asp Val Asn Asp Asn Ala Pro Val Phe Asp Pro Tyr 
705                 710                 715                 720 


Leu Pro Arg Asn Leu Ser Val Val Glu Glu Glu Ala Asn Ala Phe Val 
                725                 730                 735     


Gly Gln Val Lys Ala Thr Asp Pro Asp Ala Gly Ile Asn Gly Gln Val 
            740                 745                 750         


His Tyr Ser Leu Gly Asn Phe Asn Asn Leu Phe Arg Ile Thr Ser Asn 
        755                 760                 765             


Gly Ser Ile Tyr Thr Ala Val Lys Leu Asn Arg Glu Val Arg Asp Tyr 
    770                 775                 780                 


Tyr Glu Leu Val Val Val Ala Thr Asp Gly Ala Val His Pro Arg His 
785                 790                 795                 800 


Ser Thr Leu Thr Leu Ala Ile Lys Val Leu Asp Ile Asp Asp Asn Ser 
                805                 810                 815     


Pro Val Phe Thr Asn Ser Thr Tyr Thr Val Leu Val Glu Glu Asn Leu 
            820                 825                 830         


Pro Ala Gly Thr Thr Ile Leu Gln Ile Glu Ala Lys Asp Val Asp Leu 
        835                 840                 845             


Gly Ala Asn Val Ser Tyr Arg Ile Arg Ser Pro Glu Val Lys His Phe 
    850                 855                 860                 


Phe Ala Leu His Pro Phe Thr Gly Glu Leu Ser Leu Leu Arg Ser Leu 
865                 870                 875                 880 


Asp Tyr Glu Ala Phe Pro Asp Gln Glu Ala Ser Ile Thr Phe Leu Val 
                885                 890                 895     


Glu Ala Phe Asp Ile Tyr Gly Thr Met Pro Pro Gly Ile Ala Thr Val 
            900                 905                 910         


Thr Val Ile Val Lys Asp Met Asn Asp Tyr Pro Pro Val Phe Ser Lys 
        915                 920                 925             


Arg Ile Tyr Lys Gly Met Val Ala Pro Asp Ala Val Lys Gly Thr Pro 
    930                 935                 940                 


Ile Thr Thr Val Tyr Ala Glu Asp Ala Asp Pro Pro Gly Leu Pro Ala 
945                 950                 955                 960 


Ser Arg Val Arg Tyr Arg Val Asp Asp Val Gln Phe Pro Tyr Pro Ala 
                965                 970                 975     


Ser Ile Phe Glu Val Glu Glu Asp Ser Gly Arg Val Ile Thr Arg Val 
            980                 985                 990         


Asn Leu Asn Glu Glu Pro Thr Thr  Ile Phe Lys Leu Val  Val Val Ala 
        995                 1000                 1005             


Phe Asp  Asp Gly Glu Pro Val  Met Ser Ser Ser Ala  Thr Val Lys 
    1010                 1015                 1020             


Ile Leu  Val Leu His Pro Gly  Glu Ile Pro Arg Phe  Thr Gln Glu 
    1025                 1030                 1035             


Glu Tyr  Arg Pro Pro Pro Val  Ser Glu Leu Ala Thr  Lys Gly Thr 
    1040                 1045                 1050             


Met Val  Gly Val Ile Ser Ala  Ala Ala Ile Asn Gln  Ser Ile Val 
    1055                 1060                 1065             


Tyr Ser  Ile Val Ser Gly Asn  Glu Glu Asp Thr Phe  Gly Ile Asn 
    1070                 1075                 1080             


Asn Ile  Thr Gly Val Ile Tyr  Val Asn Gly Pro Leu  Asp Tyr Glu 
    1085                 1090                 1095             


Thr Arg  Thr Ser Tyr Val Leu  Arg Val Gln Ala Asp  Ser Leu Glu 
    1100                 1105                 1110             


Val Val  Leu Ala Asn Leu Arg  Val Pro Ser Lys Ser  Asn Thr Ala 
    1115                 1120                 1125             


Lys Val  Tyr Ile Glu Ile Gln  Asp Glu Asn Asn His  Pro Pro Val 
    1130                 1135                 1140             


Phe Gln  Lys Lys Phe Tyr Ile  Gly Gly Val Ser Glu  Asp Ala Arg 
    1145                 1150                 1155             


Met Phe  Thr Ser Val Leu Arg  Val Lys Ala Thr Asp  Lys Asp Thr 
    1160                 1165                 1170             


Gly Asn  Tyr Ser Val Met Ala  Tyr Arg Leu Ile Ile  Pro Pro Ile 
    1175                 1180                 1185             


Lys Glu  Gly Lys Glu Gly Phe  Val Val Glu Thr Tyr  Thr Gly Leu 
    1190                 1195                 1200             


Ile Lys  Thr Ala Met Leu Phe  His Asn Met Arg Arg  Ser Tyr Phe 
    1205                 1210                 1215             


Lys Phe  Gln Val Ile Ala Thr  Asp Asp Tyr Gly Lys  Gly Leu Ser 
    1220                 1225                 1230             


Gly Lys  Ala Asp Val Leu Val  Ser Val Val Asn Gln  Leu Asp Met 
    1235                 1240                 1245             


Gln Val  Ile Val Ser Asn Val  Pro Pro Thr Leu Val  Glu Lys Lys 
    1250                 1255                 1260             


Ile Glu  Asp Leu Thr Glu Ile  Leu Asp Arg Tyr Val  Gln Glu Gln 
    1265                 1270                 1275             


Ile Pro  Gly Ala Lys Val Val  Val Glu Ser Ile Gly  Ala Arg Arg 
    1280                 1285                 1290             


His Gly  Asp Ala Phe Ser Leu  Glu Asp Tyr Thr Lys  Cys Asp Leu 
    1295                 1300                 1305             


Thr Val  Tyr Ala Ile Asp Pro  Gln Thr Asn Arg Ala  Ile Asp Arg 
    1310                 1315                 1320             


Asn Glu  Leu Phe Lys Phe Leu  Asp Gly Lys Leu Leu  Asp Ile Asn 
    1325                 1330                 1335             


Lys Asp  Phe Gln Pro Tyr Tyr  Gly Glu Gly Gly Arg  Ile Leu Glu 
    1340                 1345                 1350             


Ile Arg  Thr Pro Glu Ala Val  Thr Ser Ile Lys Lys  Arg Gly Glu 
    1355                 1360                 1365             


Ser Leu  Gly Tyr Thr Glu Gly  Ala Leu Leu Ala Leu  Ala Phe Ile 
    1370                 1375                 1380             


Ile Ile  Leu Cys Cys Ile Pro  Ala Ile Leu Val Val  Leu Val Ser 
    1385                 1390                 1395             


Tyr Arg  Gln Phe Lys Val Arg  Gln Ala Glu Cys Thr  Lys Thr Ala 
    1400                 1405                 1410             


Arg Ile  Gln Ala Ala Leu Pro  Ala Ala Lys Pro Ala  Val Pro Ala 
    1415                 1420                 1425             


Pro Ala  Pro Val Ala Ala Pro  Pro Pro Pro Pro Pro  Pro Pro Pro 
    1430                 1435                 1440             


Gly Ala  His Leu Tyr Glu Glu  Leu Gly Asp Ser Ser  Ile Trp Ser 
    1445                 1450                 1455             


Phe Cys  Trp Gln Leu Val Ile  Cys Met Arg Thr Cys  Ala Ile Trp 
    1460                 1465                 1470             


Arg Thr  Leu Thr Arg Arg Gly  Tyr Gly Ser Glu Gln  Gln Gln Leu 
    1475                 1480                 1485             


Leu Arg  Pro Ser Leu Leu Lys  Pro Glu Glu Leu Ser  Met Glu Ser 
    1490                 1495                 1500             


Gly Ile  Asp Pro Gly Gln Glu  Tyr Gly Gln Asp Tyr  Tyr Ser Tyr 
    1505                 1510                 1515             


Glu His  Gly Tyr Glu Met Pro  Gln Tyr Gly Ser Arg  Arg Arg Leu 
    1520                 1525                 1530             


Leu Pro  Pro Ala Gly Gln Glu  Glu Tyr Gly Glu Val  Val Gly Glu 
    1535                 1540                 1545             


Ala Glu  Glu Glu Tyr Glu Glu  Glu Glu Trp Ala Arg  Lys Arg Met 
    1550                 1555                 1560             


Ile Lys  Leu Val Val Asp Arg  Glu Tyr Glu Thr Ser  Ser Thr Gly 
    1565                 1570                 1575             


Glu Asp  Ser Ala Pro Glu Cys  Gln Arg Asn Arg Leu  His His Pro 
    1580                 1585                 1590             


Ser Ile  His Ser Asn Ile Asn  Gly Asn Ile Tyr Ile  Ala Gln Asn 
    1595                 1600                 1605             


Gly Ser  Val Val Arg Thr Arg  Arg Ala Cys Leu Thr  Asp Asn Leu 
    1610                 1615                 1620             


Lys Val  Ala Ser Pro Val Arg  Leu Gly Gly Pro Phe  Lys Lys Leu 
    1625                 1630                 1635             


Asp Lys  Leu Ala Val Thr His  Glu Glu Asn Val Pro  Leu Asn Thr 
    1640                 1645                 1650             


Leu Ser  Lys Gly Pro Phe Ser  Thr Glu Lys Met Asn  Ala Arg Pro 
    1655                 1660                 1665             


Thr Leu  Val Thr Phe Ala Pro  Cys Pro Val Gly Thr  Asp Asn Thr 
    1670                 1675                 1680             


Ala Val  Lys Pro Leu Arg Asn  Arg Leu Lys Ser Thr  Val Glu Gln 
    1685                 1690                 1695             


Glu Ser  Met Ile Asp Ser Lys  Asn Ile Lys Glu Ala  Leu Glu Phe 
    1700                 1705                 1710             


His Ser  Asp His Thr Gln Ser  Asp Asp Glu Glu Leu  Trp Met Gly 
    1715                 1720                 1725             


Pro Trp  Asn Asn Leu His Ile  Pro Met Thr Lys Leu  
    1730                 1735                 1740 


<210>  10074
<211>  1888
<212>  PRT
<213>  Homo Sapiens

<400>  10074

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Cys 
            20                  25                  30          


Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile Val Ala Ile Asp Glu 
        35                  40                  45              


Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn Met Leu Ile Lys Gly 
    50                  55                  60                  


Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu Ser Leu Lys Asp Asn 
65                  70                  75                  80  


Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys Gln Met Leu Phe Leu 
                85                  90                  95      


Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro Pro Met Asn Ile His 
            100                 105                 110         


Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys Lys Val Gly Thr Ile 
        115                 120                 125             


Ile Tyr His Glu Val Arg Ile Val Val Arg Asp Arg Asn Asp Asn Ser 
    130                 135                 140                 


Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr Val Asn Glu Leu Thr 
145                 150                 155                 160 


Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser Gly Asp Asn Gly Ala 
                165                 170                 175     


Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile Glu Tyr Val Ile Gln 
            180                 185                 190         


Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr Phe Glu Ile Pro Leu 
        195                 200                 205             


Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg Leu Asn Tyr Glu Asp 
    210                 215                 220                 


Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn Asp Arg Ala Gln Asn 
225                 230                 235                 240 


Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu Thr Val Asp Val Leu 
                245                 250                 255     


Asp Gly Asp Asp Leu Gly Pro Met Phe Leu Pro Cys Val Leu Val Pro 
            260                 265                 270         


Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln Ala Ala Ile Pro Glu 
        275                 280                 285             


Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile Val Thr Pro Pro Ile 
    290                 295                 300                 


Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro Pro Ser Asp Arg Pro 
305                 310                 315                 320 


Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro Glu Asp Tyr Pro Arg 
                325                 330                 335     


Phe Phe His Met His Pro Arg Thr Ala Glu Leu Ser Leu Leu Glu Pro 
            340                 345                 350         


Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu Val Ile Lys Ala Glu 
        355                 360                 365             


Gln Asp Asn Gly His Pro Leu Pro Ala Phe Ala Gly Leu His Ile Glu 
    370                 375                 380                 


Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe Thr Met Pro Ser Tyr 
385                 390                 395                 400 


Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly Ala Thr Ile Ser Asp 
                405                 410                 415     


Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val Ala Leu Asp Lys Asp 
            420                 425                 430         


Ile Glu Asp Thr Lys Asp Pro Glu Leu His Leu Phe Leu Asn Asp Tyr 
        435                 440                 445             


Thr Ser Val Phe Thr Val Thr Gln Thr Gly Ile Thr Arg Tyr Leu Thr 
    450                 455                 460                 


Leu Leu Gln Pro Val Asp Arg Glu Glu Gln Gln Thr Tyr Thr Phe Ser 
465                 470                 475                 480 


Ile Thr Ala Phe Asp Gly Val Gln Glu Ser Glu Pro Val Ile Val Asn 
                485                 490                 495     


Ile Gln Val Met Asp Ala Asn Asp Asn Thr Pro Thr Phe Pro Glu Ile 
            500                 505                 510         


Ser Tyr Asp Val Tyr Val Tyr Thr Asp Met Arg Pro Gly Asp Ser Val 
        515                 520                 525             


Ile Gln Leu Thr Ala Val Asp Ala Asp Glu Gly Ser Asn Gly Glu Ile 
    530                 535                 540                 


Thr Tyr Glu Ile Leu Val Gly Ala Gln Gly Asp Phe Ile Ile Asn Lys 
545                 550                 555                 560 


Thr Thr Gly Leu Ile Thr Ile Ala Pro Gly Val Glu Met Ile Val Gly 
                565                 570                 575     


Arg Thr Tyr Ala Leu Thr Val Gln Ala Ala Asp Asn Ala Pro Pro Ala 
            580                 585                 590         


Glu Arg Ser Thr Gly Ile Leu Thr Leu Gly Lys Ala Leu Asp Arg Glu 
        595                 600                 605             


Ser Thr Asp Arg Tyr Ile Leu Ile Ile Thr Ala Ser Asp Gly Arg Pro 
    610                 615                 620                 


Asp Gly Thr Ser Thr Ala Thr Val Asn Ile Val Val Thr Asp Val Asn 
625                 630                 635                 640 


Asp Asn Ala Pro Val Phe Asp Pro Tyr Leu Pro Arg Asn Leu Ser Val 
                645                 650                 655     


Val Glu Glu Glu Ala Asn Ala Phe Val Gly Gln Val Lys Ala Thr Asp 
            660                 665                 670         


Pro Asp Ala Gly Ile Asn Gly Gln Val His Tyr Ser Leu Gly Asn Phe 
        675                 680                 685             


Asn Asn Leu Phe Arg Ile Thr Ser Asn Gly Ser Ile Tyr Thr Ala Val 
    690                 695                 700                 


Lys Leu Asn Arg Glu Val Arg Asp Tyr Tyr Glu Leu Val Val Val Ala 
705                 710                 715                 720 


Thr Asp Gly Ala Val His Pro Arg His Ser Thr Leu Thr Leu Ala Ile 
                725                 730                 735     


Lys Val Leu Asp Ile Asp Asp Asn Ser Pro Val Phe Thr Asn Ser Thr 
            740                 745                 750         


Tyr Thr Val Leu Val Glu Glu Asn Leu Pro Ala Gly Thr Thr Ile Leu 
        755                 760                 765             


Gln Ile Glu Ala Lys Asp Val Asp Leu Gly Ala Asn Val Ser Tyr Arg 
    770                 775                 780                 


Ile Arg Ser Pro Glu Val Lys His Phe Phe Ala Leu His Pro Phe Thr 
785                 790                 795                 800 


Gly Glu Leu Ser Leu Leu Arg Ser Leu Asp Tyr Glu Ala Phe Pro Asp 
                805                 810                 815     


Gln Glu Ala Ser Ile Thr Phe Leu Val Glu Ala Phe Asp Ile Tyr Gly 
            820                 825                 830         


Thr Met Pro Pro Gly Ile Ala Thr Val Thr Val Ile Val Lys Asp Met 
        835                 840                 845             


Asn Asp Tyr Pro Pro Val Phe Ser Lys Arg Ile Tyr Lys Gly Met Val 
    850                 855                 860                 


Ala Pro Asp Ala Val Lys Gly Thr Pro Ile Thr Thr Val Tyr Ala Glu 
865                 870                 875                 880 


Asp Ala Asp Pro Pro Gly Leu Pro Ala Ser Arg Val Arg Tyr Arg Val 
                885                 890                 895     


Asp Asp Val Gln Phe Pro Tyr Pro Ala Ser Ile Phe Glu Val Glu Glu 
            900                 905                 910         


Asp Ser Gly Arg Val Ile Thr Arg Val Asn Leu Asn Glu Glu Pro Thr 
        915                 920                 925             


Thr Ile Phe Lys Leu Val Val Val Ala Phe Asp Asp Gly Glu Pro Val 
    930                 935                 940                 


Met Ser Ser Ser Ala Thr Val Lys Ile Leu Val Leu His Pro Gly Glu 
945                 950                 955                 960 


Ile Pro Arg Phe Thr Gln Glu Glu Tyr Arg Pro Pro Pro Val Ser Glu 
                965                 970                 975     


Leu Ala Thr Lys Gly Thr Met Val Gly Val Ile Ser Ala Ala Ala Ile 
            980                 985                 990         


Asn Gln Ser Ile Val Tyr Ser Ile  Val Ser Gly Asn Glu  Glu Asp Thr 
        995                 1000                 1005             


Phe Gly  Ile Asn Asn Ile Thr  Gly Val Ile Tyr Val  Asn Gly Pro 
    1010                 1015                 1020             


Leu Asp  Tyr Glu Thr Arg Thr  Ser Tyr Val Leu Arg  Val Gln Ala 
    1025                 1030                 1035             


Asp Ser  Leu Glu Val Val Leu  Ala Asn Leu Arg Val  Pro Ser Lys 
    1040                 1045                 1050             


Ser Asn  Thr Ala Lys Val Tyr  Ile Glu Ile Gln Asp  Glu Asn Asn 
    1055                 1060                 1065             


His Pro  Pro Val Phe Gln Lys  Lys Phe Tyr Ile Gly  Gly Val Ser 
    1070                 1075                 1080             


Glu Asp  Ala Arg Met Phe Thr  Ser Val Leu Arg Val  Lys Ala Thr 
    1085                 1090                 1095             


Asp Lys  Asp Thr Gly Asn Tyr  Ser Val Met Ala Tyr  Arg Leu Ile 
    1100                 1105                 1110             


Ile Pro  Pro Ile Lys Glu Gly  Lys Glu Gly Phe Val  Val Glu Thr 
    1115                 1120                 1125             


Tyr Thr  Gly Leu Ile Lys Thr  Ala Met Leu Phe His  Asn Met Arg 
    1130                 1135                 1140             


Arg Ser  Tyr Phe Lys Phe Gln  Val Ile Ala Thr Asp  Asp Tyr Gly 
    1145                 1150                 1155             


Lys Gly  Leu Ser Gly Lys Ala  Asp Val Leu Val Ser  Val Val Asn 
    1160                 1165                 1170             


Gln Leu  Asp Met Gln Val Ile  Val Ser Asn Val Pro  Pro Thr Leu 
    1175                 1180                 1185             


Val Glu  Lys Lys Ile Glu Asp  Leu Thr Glu Ile Leu  Asp Arg Tyr 
    1190                 1195                 1200             


Val Gln  Glu Gln Ile Pro Gly  Ala Lys Val Val Val  Glu Ser Ile 
    1205                 1210                 1215             


Gly Ala  Arg Arg His Gly Asp  Ala Phe Ser Leu Glu  Asp Tyr Thr 
    1220                 1225                 1230             


Lys Cys  Asp Leu Thr Val Tyr  Ala Ile Asp Pro Gln  Thr Asn Arg 
    1235                 1240                 1245             


Ala Ile  Asp Arg Asn Glu Leu  Phe Lys Phe Leu Asp  Gly Lys Leu 
    1250                 1255                 1260             


Leu Asp  Ile Asn Lys Asp Phe  Gln Pro Tyr Tyr Gly  Glu Gly Gly 
    1265                 1270                 1275             


Arg Ile  Leu Glu Ile Arg Thr  Pro Glu Ala Val Thr  Ser Ile Lys 
    1280                 1285                 1290             


Lys Arg  Gly Glu Ser Leu Gly  Tyr Thr Glu Gly Ala  Leu Leu Ala 
    1295                 1300                 1305             


Leu Ala  Phe Ile Ile Ile Leu  Cys Cys Ile Pro Ala  Ile Leu Val 
    1310                 1315                 1320             


Val Leu  Val Ser Tyr Arg Gln  Val Phe Lys Gly Arg  Gln Ala Glu 
    1325                 1330                 1335             


Cys Thr  Lys Thr Ala Arg Ile  Gln Ala Ala Leu Pro  Ala Ala Lys 
    1340                 1345                 1350             


Pro Ala  Val Pro Ala Pro Ala  Pro Val Ala Ala Pro  Pro Pro Pro 
    1355                 1360                 1365             


Pro Pro  Pro Pro Pro Gly Ala  His Leu Tyr Glu Glu  Leu Gly Asp 
    1370                 1375                 1380             


Ser Ser  Ile Leu Ser Ser Leu  Phe Leu Leu Tyr His  Phe Gln Gln 
    1385                 1390                 1395             


Ser Arg  Gly Asn Asn Ser Val  Ser Glu Asp Arg Lys  His Gln Gln 
    1400                 1405                 1410             


Val Val  Met Pro Phe Ser Ser  Asn Thr Ile Glu Ala  His Lys Ser 
    1415                 1420                 1425             


Ala His  Val Asp Gly Ser Leu  Lys Ser Asn Lys Leu  Lys Ser Ala 
    1430                 1435                 1440             


Arg Lys  Phe Thr Phe Leu Ser  Asp Glu Asp Asp Leu  Ser Ala His 
    1445                 1450                 1455             


Asn Pro  Leu Tyr Lys Glu Asn  Ile Ser Gln Val Ser  Thr Asn Ser 
    1460                 1465                 1470             


Asp Ile  Ser Gln Arg Thr Asp  Phe Val Asp Pro Phe  Ser Pro Lys 
    1475                 1480                 1485             


Ile Gln  Ala Lys Ser Lys Ser  Leu Arg Gly Pro Arg  Glu Lys Ile 
    1490                 1495                 1500             


Gln Arg  Leu Trp Ser Gln Ser  Val Ser Leu Pro Arg  Arg Leu Met 
    1505                 1510                 1515             


Arg Lys  Val Pro Asn Arg Pro  Glu Ile Ile Asp Leu  Gln Gln Trp 
    1520                 1525                 1530             


Gln Gly  Thr Arg Gln Lys Ala  Glu Asn Glu Asn Thr  Gly Ile Cys 
    1535                 1540                 1545             


Thr Asn  Lys Arg Gly Ser Ser  Asn Pro Leu Leu Thr  Thr Glu Glu 
    1550                 1555                 1560             


Ala Asn  Leu Thr Glu Lys Glu  Glu Ile Arg Gln Gly  Glu Thr Leu 
    1565                 1570                 1575             


Met Ile  Glu Gly Thr Glu Gln  Leu Lys Ser Leu Ser  Ser Asp Ser 
    1580                 1585                 1590             


Ser Phe  Cys Phe Pro Arg Pro  His Phe Ser Phe Ser  Thr Leu Pro 
    1595                 1600                 1605             


Thr Val  Ser Arg Thr Val Glu  Leu Lys Ser Glu Pro  Asn Val Ile 
    1610                 1615                 1620             


Ser Ser  Pro Ala Glu Cys Ser  Leu Glu Leu Ser Pro  Ser Arg Pro 
    1625                 1630                 1635             


Cys Val  Leu His Ser Ser Leu  Ser Arg Arg Glu Thr  Pro Ile Cys 
    1640                 1645                 1650             


Met Leu  Pro Ile Glu Thr Glu  Arg Asn Ile Phe Glu  Asn Phe Ala 
    1655                 1660                 1665             


His Pro  Pro Asn Ile Ser Pro  Ser Ala Cys Pro Leu  Pro Pro Pro 
    1670                 1675                 1680             


Pro Pro  Ile Ser Pro Pro Ser  Pro Pro Pro Ala Pro  Ala Pro Leu 
    1685                 1690                 1695             


Ala Pro  Pro Pro Asp Ile Ser  Pro Phe Ser Leu Phe  Cys Pro Pro 
    1700                 1705                 1710             


Pro Ser  Pro Pro Ser Ile Pro  Leu Pro Leu Pro Pro  Pro Thr Phe 
    1715                 1720                 1725             


Phe Pro  Leu Ser Val Ser Thr  Ser Gly Pro Pro Thr  Pro Pro Leu 
    1730                 1735                 1740             


Leu Pro  Pro Phe Pro Thr Pro  Leu Pro Pro Pro Pro  Pro Ser Ile 
    1745                 1750                 1755             


Pro Cys  Pro Pro Pro Pro Ser  Ala Ser Phe Leu Ser  Thr Glu Cys 
    1760                 1765                 1770             


Val Cys  Ile Thr Gly Val Lys  Cys Thr Thr Asn Leu  Met Pro Ala 
    1775                 1780                 1785             


Glu Lys  Ile Lys Ser Ser Met  Thr Gln Leu Ser Thr  Thr Thr Val 
    1790                 1795                 1800             


Cys Lys  Thr Asp Pro Gln Arg  Glu Pro Lys Gly Ile  Leu Arg His 
    1805                 1810                 1815             


Val Lys  Asn Leu Ala Glu Leu  Glu Lys Ser Val Ala  Asn Met Tyr 
    1820                 1825                 1830             


Ser Gln  Ile Glu Lys Asn Tyr  Leu Arg Thr Asn Val  Ser Glu Leu 
    1835                 1840                 1845             


Gln Thr  Met Cys Pro Ser Glu  Val Thr Asn Met Glu  Ile Thr Ser 
    1850                 1855                 1860             


Glu Gln  Asn Lys Gly Ser Leu  Asn Asn Ile Val Glu  Gly Thr Glu 
    1865                 1870                 1875             


Lys Gln  Ser His Ser Gln Ser  Thr Ser Leu 
    1880                 1885             


<210>  10075
<211>  1962
<212>  PRT
<213>  Homo Sapiens

<400>  10075

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Trp 
            20                  25                  30          


Gln Tyr Glu Asp Cys Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile 
        35                  40                  45              


Val Ala Ile Asp Glu Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn 
    50                  55                  60                  


Met Leu Ile Lys Gly Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu 
65                  70                  75                  80  


Ser Leu Lys Asp Asn Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys 
                85                  90                  95      


Gln Met Leu Phe Leu Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro 
            100                 105                 110         


Pro Met Asn Ile His Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys 
        115                 120                 125             


Lys Val Gly Thr Ile Ile Tyr His Glu Val Arg Ile Val Val Arg Asp 
    130                 135                 140                 


Arg Asn Asp Asn Ser Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr 
145                 150                 155                 160 


Val Asn Glu Leu Thr Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser 
                165                 170                 175     


Gly Asp Asn Gly Ala Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile 
            180                 185                 190         


Glu Tyr Val Ile Gln Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr 
        195                 200                 205             


Phe Glu Ile Pro Leu Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg 
    210                 215                 220                 


Leu Asn Tyr Glu Asp Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn 
225                 230                 235                 240 


Asp Arg Ala Gln Asn Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu 
                245                 250                 255     


Thr Val Asp Val Leu Asp Gly Asp Asp Leu Gly Pro Met Phe Leu Pro 
            260                 265                 270         


Cys Val Leu Val Pro Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln 
        275                 280                 285             


Ala Ala Ile Pro Glu Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile 
    290                 295                 300                 


Val Thr Pro Pro Ile Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro 
305                 310                 315                 320 


Pro Ser Asp Arg Pro Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro 
                325                 330                 335     


Glu Asp Tyr Pro Arg Phe Phe His Met His Pro Arg Thr Ala Glu Leu 
            340                 345                 350         


Ser Leu Leu Glu Pro Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu 
        355                 360                 365             


Val Ile Lys Ala Glu Gln Asp Asn Gly His Pro Leu Pro Ala Phe Ala 
    370                 375                 380                 


Gly Leu His Ile Glu Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe 
385                 390                 395                 400 


Thr Met Pro Ser Tyr Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly 
                405                 410                 415     


Ala Thr Ile Ser Asp Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val 
            420                 425                 430         


Ala Leu Asp Lys Asp Ile Glu Asp Thr Lys Asp Pro Glu Leu His Leu 
        435                 440                 445             


Phe Leu Asn Asp Tyr Thr Ser Val Phe Thr Val Thr Gln Thr Gly Ile 
    450                 455                 460                 


Thr Arg Tyr Leu Thr Leu Leu Gln Pro Val Asp Arg Glu Glu Gln Gln 
465                 470                 475                 480 


Thr Tyr Thr Phe Ser Ile Thr Ala Phe Asp Gly Val Gln Glu Ser Glu 
                485                 490                 495     


Pro Val Ile Val Asn Ile Gln Val Met Asp Ala Asn Asp Asn Thr Pro 
            500                 505                 510         


Thr Phe Pro Glu Ile Ser Tyr Asp Val Tyr Val Tyr Thr Asp Met Arg 
        515                 520                 525             


Pro Gly Asp Ser Val Ile Gln Leu Thr Ala Val Asp Ala Asp Glu Gly 
    530                 535                 540                 


Ser Asn Gly Glu Ile Thr Tyr Glu Ile Leu Val Gly Ala Gln Gly Asp 
545                 550                 555                 560 


Phe Ile Ile Asn Lys Thr Thr Gly Leu Ile Thr Ile Ala Pro Gly Val 
                565                 570                 575     


Glu Met Ile Val Gly Arg Thr Tyr Ala Leu Thr Val Gln Ala Ala Asp 
            580                 585                 590         


Asn Ala Pro Pro Ala Glu Arg Arg Asn Ser Ile Cys Thr Val Tyr Ile 
        595                 600                 605             


Glu Val Leu Pro Pro Asn Asn Gln Ser Pro Pro Arg Phe Pro Gln Leu 
    610                 615                 620                 


Met Tyr Ser Leu Glu Ile Ser Glu Ala Met Arg Val Gly Ala Val Leu 
625                 630                 635                 640 


Leu Asn Leu Gln Ala Thr Asp Arg Glu Gly Asp Ser Ile Thr Tyr Ala 
                645                 650                 655     


Ile Glu Asn Gly Asp Pro Gln Arg Val Phe Asn Leu Ser Glu Thr Thr 
            660                 665                 670         


Gly Ile Leu Thr Leu Gly Lys Ala Leu Asp Arg Glu Ser Thr Asp Arg 
        675                 680                 685             


Tyr Ile Leu Ile Ile Thr Ala Ser Asp Gly Arg Pro Asp Gly Thr Ser 
    690                 695                 700                 


Thr Ala Thr Val Asn Ile Val Val Thr Asp Val Asn Asp Asn Ala Pro 
705                 710                 715                 720 


Val Phe Asp Pro Tyr Leu Pro Arg Asn Leu Ser Val Val Glu Glu Glu 
                725                 730                 735     


Ala Asn Ala Phe Val Gly Gln Val Lys Ala Thr Asp Pro Asp Ala Gly 
            740                 745                 750         


Ile Asn Gly Gln Val His Tyr Ser Leu Gly Asn Phe Asn Asn Leu Phe 
        755                 760                 765             


Arg Ile Thr Ser Asn Gly Ser Ile Tyr Thr Ala Val Lys Leu Asn Arg 
    770                 775                 780                 


Glu Val Arg Asp Tyr Tyr Glu Leu Val Val Val Ala Thr Asp Gly Ala 
785                 790                 795                 800 


Val His Pro Arg His Ser Thr Leu Thr Leu Ala Ile Lys Val Leu Asp 
                805                 810                 815     


Ile Asp Asp Asn Ser Pro Val Phe Thr Asn Ser Thr Tyr Thr Val Leu 
            820                 825                 830         


Val Glu Glu Asn Leu Pro Ala Gly Thr Thr Ile Leu Gln Ile Glu Ala 
        835                 840                 845             


Lys Asp Val Asp Leu Gly Ala Asn Val Ser Tyr Arg Ile Arg Ser Pro 
    850                 855                 860                 


Glu Val Lys His Phe Phe Ala Leu His Pro Phe Thr Gly Glu Leu Ser 
865                 870                 875                 880 


Leu Leu Arg Ser Leu Asp Tyr Glu Ala Phe Pro Asp Gln Glu Ala Ser 
                885                 890                 895     


Ile Thr Phe Leu Val Glu Ala Phe Asp Ile Tyr Gly Thr Met Pro Pro 
            900                 905                 910         


Gly Ile Ala Thr Val Thr Val Ile Val Lys Asp Met Asn Asp Tyr Pro 
        915                 920                 925             


Pro Val Phe Ser Lys Arg Ile Tyr Lys Gly Met Val Ala Pro Asp Ala 
    930                 935                 940                 


Val Lys Gly Thr Pro Ile Thr Thr Val Tyr Ala Glu Asp Ala Asp Pro 
945                 950                 955                 960 


Pro Gly Leu Pro Ala Ser Arg Val Arg Tyr Arg Val Asp Asp Val Gln 
                965                 970                 975     


Phe Pro Tyr Pro Ala Ser Ile Phe Glu Val Glu Glu Asp Ser Gly Arg 
            980                 985                 990         


Val Ile Thr Arg Val Asn Leu Asn  Glu Glu Pro Thr Thr  Ile Phe Lys 
        995                 1000                 1005             


Leu Val  Val Val Ala Phe Asp  Asp Gly Glu Pro Val  Met Ser Ser 
    1010                 1015                 1020             


Ser Ala  Thr Val Lys Ile Leu  Val Leu His Pro Gly  Glu Ile Pro 
    1025                 1030                 1035             


Arg Phe  Thr Gln Glu Glu Tyr  Arg Pro Pro Pro Val  Ser Glu Leu 
    1040                 1045                 1050             


Ala Thr  Lys Gly Thr Met Val  Gly Val Ile Ser Ala  Ala Ala Ile 
    1055                 1060                 1065             


Asn Gln  Ser Ile Val Tyr Ser  Ile Val Ser Gly Asn  Glu Glu Asp 
    1070                 1075                 1080             


Thr Phe  Gly Ile Asn Asn Ile  Thr Gly Val Ile Tyr  Val Asn Gly 
    1085                 1090                 1095             


Pro Leu  Asp Tyr Glu Thr Arg  Thr Ser Tyr Val Leu  Arg Val Gln 
    1100                 1105                 1110             


Ala Asp  Ser Leu Glu Val Val  Leu Ala Asn Leu Arg  Val Pro Ser 
    1115                 1120                 1125             


Lys Ser  Asn Thr Ala Lys Val  Tyr Ile Glu Ile Gln  Asp Glu Asn 
    1130                 1135                 1140             


Asn His  Pro Pro Val Phe Gln  Lys Lys Phe Tyr Ile  Gly Gly Val 
    1145                 1150                 1155             


Ser Glu  Asp Ala Arg Met Phe  Thr Ser Val Leu Arg  Val Lys Ala 
    1160                 1165                 1170             


Thr Asp  Lys Asp Thr Gly Asn  Tyr Ser Val Met Ala  Tyr Arg Leu 
    1175                 1180                 1185             


Ile Ile  Pro Pro Ile Lys Glu  Gly Lys Glu Gly Phe  Val Val Glu 
    1190                 1195                 1200             


Thr Tyr  Thr Gly Leu Ile Lys  Thr Ala Met Leu Phe  His Asn Met 
    1205                 1210                 1215             


Arg Arg  Ser Tyr Phe Lys Phe  Gln Val Ile Ala Thr  Asp Asp Tyr 
    1220                 1225                 1230             


Gly Lys  Gly Leu Ser Gly Lys  Ala Asp Val Leu Val  Ser Val Val 
    1235                 1240                 1245             


Asn Gln  Leu Asp Met Gln Val  Ile Val Ser Asn Val  Pro Pro Thr 
    1250                 1255                 1260             


Leu Val  Glu Lys Lys Ile Glu  Asp Leu Thr Glu Ile  Leu Asp Arg 
    1265                 1270                 1275             


Tyr Val  Gln Glu Gln Ile Pro  Gly Ala Lys Val Val  Val Glu Ser 
    1280                 1285                 1290             


Ile Gly  Ala Arg Arg His Gly  Asp Ala Phe Ser Leu  Glu Asp Tyr 
    1295                 1300                 1305             


Thr Lys  Cys Asp Leu Thr Val  Tyr Ala Ile Asp Pro  Gln Thr Asn 
    1310                 1315                 1320             


Arg Ala  Ile Asp Arg Asn Glu  Leu Phe Lys Phe Leu  Asp Gly Lys 
    1325                 1330                 1335             


Leu Leu  Asp Ile Asn Lys Asp  Phe Gln Pro Tyr Tyr  Gly Glu Gly 
    1340                 1345                 1350             


Gly Arg  Ile Leu Glu Ile Arg  Thr Pro Glu Ala Val  Thr Ser Ile 
    1355                 1360                 1365             


Lys Lys  Arg Gly Glu Ser Leu  Gly Tyr Thr Glu Gly  Ala Leu Leu 
    1370                 1375                 1380             


Ala Leu  Ala Phe Ile Ile Ile  Leu Cys Cys Ile Pro  Ala Ile Leu 
    1385                 1390                 1395             


Val Val  Leu Val Ser Tyr Arg  Gln Phe Lys Val Arg  Gln Ala Glu 
    1400                 1405                 1410             


Cys Thr  Lys Thr Ala Arg Ile  Gln Ala Ala Leu Pro  Ala Ala Lys 
    1415                 1420                 1425             


Pro Ala  Val Pro Ala Pro Ala  Pro Val Ala Ala Pro  Pro Pro Pro 
    1430                 1435                 1440             


Pro Pro  Pro Pro Pro Gly Ala  His Leu Tyr Glu Glu  Leu Gly Asp 
    1445                 1450                 1455             


Ser Ser  Met His Asn Leu Phe  Leu Leu Tyr His Phe  Gln Gln Ser 
    1460                 1465                 1470             


Arg Gly  Asn Asn Ser Val Ser  Glu Asp Arg Lys His  Gln Gln Val 
    1475                 1480                 1485             


Val Met  Pro Phe Ser Ser Asn  Thr Ile Glu Ala His  Lys Ser Ala 
    1490                 1495                 1500             


His Val  Asp Gly Ser Leu Lys  Ser Asn Lys Leu Lys  Ser Ala Arg 
    1505                 1510                 1515             


Lys Phe  Thr Phe Leu Ser Asp  Glu Asp Asp Leu Ser  Ala His Asn 
    1520                 1525                 1530             


Pro Leu  Tyr Lys Glu Asn Ile  Ser Gln Val Ser Thr  Asn Ser Asp 
    1535                 1540                 1545             


Ile Ser  Gln Arg Thr Asp Phe  Val Asp Pro Phe Ser  Pro Lys Ile 
    1550                 1555                 1560             


Gln Ala  Lys Ser Lys Ser Leu  Arg Gly Pro Arg Glu  Lys Ile Gln 
    1565                 1570                 1575             


Arg Leu  Trp Ser Gln Ser Val  Ser Leu Pro Arg Arg  Leu Met Arg 
    1580                 1585                 1590             


Lys Val  Pro Asn Arg Pro Glu  Ile Ile Asp Leu Gln  Gln Trp Gln 
    1595                 1600                 1605             


Gly Thr  Arg Gln Lys Ala Glu  Asn Glu Asn Thr Gly  Ile Cys Thr 
    1610                 1615                 1620             


Asn Lys  Arg Gly Ser Ser Asn  Pro Leu Leu Thr Thr  Glu Glu Ala 
    1625                 1630                 1635             


Asn Leu  Thr Glu Lys Glu Glu  Ile Arg Gln Gly Glu  Thr Leu Met 
    1640                 1645                 1650             


Ile Glu  Gly Thr Glu Gln Leu  Lys Ser Leu Ser Ser  Asp Ser Ser 
    1655                 1660                 1665             


Phe Cys  Phe Pro Arg Pro His  Phe Ser Phe Ser Thr  Leu Pro Thr 
    1670                 1675                 1680             


Val Ser  Arg Thr Val Glu Leu  Lys Ser Glu Pro Asn  Val Ile Ser 
    1685                 1690                 1695             


Ser Pro  Ala Glu Cys Ser Leu  Glu Leu Ser Pro Ser  Arg Pro Cys 
    1700                 1705                 1710             


Val Leu  His Ser Ser Leu Ser  Arg Arg Glu Thr Pro  Ile Cys Met 
    1715                 1720                 1725             


Leu Pro  Ile Glu Thr Glu Arg  Asn Ile Phe Glu Asn  Phe Ala His 
    1730                 1735                 1740             


Pro Pro  Asn Ile Ser Pro Ser  Ala Cys Pro Leu Pro  Pro Pro Pro 
    1745                 1750                 1755             


Pro Ile  Ser Pro Pro Ser Pro  Pro Pro Ala Pro Ala  Pro Leu Ala 
    1760                 1765                 1770             


Pro Pro  Pro Asp Ile Ser Pro  Phe Ser Leu Phe Cys  Pro Pro Pro 
    1775                 1780                 1785             


Ser Pro  Pro Ser Ile Pro Leu  Pro Leu Pro Pro Pro  Thr Phe Phe 
    1790                 1795                 1800             


Pro Leu  Ser Val Ser Thr Ser  Gly Pro Pro Thr Pro  Pro Leu Leu 
    1805                 1810                 1815             


Pro Pro  Phe Pro Thr Pro Leu  Pro Pro Pro Pro Pro  Ser Ile Pro 
    1820                 1825                 1830             


Cys Pro  Pro Pro Pro Ser Ala  Ser Phe Leu Ser Thr  Glu Cys Val 
    1835                 1840                 1845             


Cys Ile  Thr Gly Val Lys Cys  Thr Thr Asn Leu Met  Pro Ala Glu 
    1850                 1855                 1860             


Lys Ile  Lys Ser Ser Met Thr  Gln Leu Ser Thr Thr  Thr Val Cys 
    1865                 1870                 1875             


Lys Thr  Asp Pro Gln Arg Glu  Pro Lys Gly Ile Leu  Arg His Val 
    1880                 1885                 1890             


Lys Asn  Leu Ala Glu Leu Glu  Lys Ser Val Ala Asn  Met Tyr Ser 
    1895                 1900                 1905             


Gln Ile  Glu Lys Asn Tyr Leu  Arg Thr Asn Val Ser  Glu Leu Gln 
    1910                 1915                 1920             


Thr Met  Cys Pro Ser Glu Val  Thr Asn Met Glu Ile  Thr Ser Glu 
    1925                 1930                 1935             


Gln Asn  Lys Gly Ser Leu Asn  Asn Ile Val Glu Gly  Thr Glu Lys 
    1940                 1945                 1950             


Gln Ser  His Ser Gln Ser Thr  Ser Leu 
    1955                 1960         


<210>  10076
<211>  1789
<212>  PRT
<213>  Homo Sapiens

<400>  10076

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Trp 
            20                  25                  30          


Gln Tyr Glu Asp Cys Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile 
        35                  40                  45              


Val Ala Ile Asp Glu Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn 
    50                  55                  60                  


Met Leu Ile Lys Gly Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu 
65                  70                  75                  80  


Ser Leu Lys Asp Asn Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys 
                85                  90                  95      


Gln Met Leu Phe Leu Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro 
            100                 105                 110         


Pro Met Asn Ile His Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys 
        115                 120                 125             


Lys Val Gly Thr Ile Ile Tyr His Glu Val Arg Ile Val Val Arg Asp 
    130                 135                 140                 


Arg Asn Asp Asn Ser Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr 
145                 150                 155                 160 


Val Asn Glu Leu Thr Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser 
                165                 170                 175     


Gly Asp Asn Gly Ala Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile 
            180                 185                 190         


Glu Tyr Val Ile Gln Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr 
        195                 200                 205             


Phe Glu Ile Pro Leu Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg 
    210                 215                 220                 


Leu Asn Tyr Glu Asp Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn 
225                 230                 235                 240 


Asp Arg Ala Gln Asn Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu 
                245                 250                 255     


Thr Val Asp Val Leu Asp Gly Asp Asp Leu Gly Pro Met Phe Leu Pro 
            260                 265                 270         


Cys Val Leu Val Pro Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln 
        275                 280                 285             


Ala Ala Ile Pro Glu Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile 
    290                 295                 300                 


Val Thr Pro Pro Ile Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro 
305                 310                 315                 320 


Pro Ser Asp Arg Pro Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro 
                325                 330                 335     


Glu Asp Tyr Pro Arg Phe Phe His Met His Pro Arg Thr Ala Glu Leu 
            340                 345                 350         


Ser Leu Leu Glu Pro Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu 
        355                 360                 365             


Val Ile Lys Ala Glu Gln Asp Asn Gly His Pro Leu Pro Ala Phe Ala 
    370                 375                 380                 


Gly Leu His Ile Glu Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe 
385                 390                 395                 400 


Thr Met Pro Ser Tyr Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly 
                405                 410                 415     


Ala Thr Ile Ser Asp Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val 
            420                 425                 430         


Ala Leu Asp Lys Asp Ile Glu Asp Val Pro Pro Ser Gly Val Pro Thr 
        435                 440                 445             


Lys Asp Pro Glu Leu His Leu Phe Leu Asn Asp Tyr Thr Ser Val Phe 
    450                 455                 460                 


Thr Val Thr Gln Thr Gly Ile Thr Arg Tyr Leu Thr Leu Leu Gln Pro 
465                 470                 475                 480 


Val Asp Arg Glu Glu Gln Gln Thr Tyr Thr Phe Ser Ile Thr Ala Phe 
                485                 490                 495     


Asp Gly Val Gln Glu Ser Glu Pro Val Ile Val Asn Ile Gln Val Met 
            500                 505                 510         


Asp Ala Asn Asp Asn Thr Pro Thr Phe Pro Glu Ile Ser Tyr Asp Val 
        515                 520                 525             


Tyr Val Tyr Thr Asp Met Arg Pro Gly Asp Ser Val Ile Gln Leu Thr 
    530                 535                 540                 


Ala Val Asp Ala Asp Glu Gly Ser Asn Gly Glu Ile Thr Tyr Glu Ile 
545                 550                 555                 560 


Leu Val Gly Ala Gln Gly Asp Phe Ile Ile Asn Lys Thr Thr Gly Leu 
                565                 570                 575     


Ile Thr Ile Ala Pro Gly Val Glu Met Ile Val Gly Arg Thr Tyr Ala 
            580                 585                 590         


Leu Thr Val Gln Ala Ala Asp Asn Ala Pro Pro Ala Glu Arg Arg Asn 
        595                 600                 605             


Ser Ile Cys Thr Val Tyr Ile Glu Val Leu Pro Pro Asn Asn Gln Ser 
    610                 615                 620                 


Pro Pro Arg Phe Pro Gln Leu Met Tyr Ser Leu Glu Ile Ser Glu Ala 
625                 630                 635                 640 


Met Arg Val Gly Ala Val Leu Leu Asn Leu Gln Ala Thr Asp Arg Glu 
                645                 650                 655     


Gly Asp Ser Ile Thr Tyr Ala Ile Glu Asn Gly Asp Pro Gln Arg Val 
            660                 665                 670         


Phe Asn Leu Ser Glu Thr Thr Gly Ile Leu Thr Leu Gly Lys Ala Leu 
        675                 680                 685             


Asp Arg Glu Ser Thr Asp Arg Tyr Ile Leu Ile Ile Thr Ala Ser Asp 
    690                 695                 700                 


Gly Arg Pro Asp Gly Thr Ser Thr Ala Thr Val Asn Ile Val Val Thr 
705                 710                 715                 720 


Asp Val Asn Asp Asn Ala Pro Val Phe Asp Pro Tyr Leu Pro Arg Asn 
                725                 730                 735     


Leu Ser Val Val Glu Glu Glu Ala Asn Ala Phe Val Gly Gln Val Lys 
            740                 745                 750         


Ala Thr Asp Pro Asp Ala Gly Ile Asn Gly Gln Val His Tyr Ser Leu 
        755                 760                 765             


Gly Asn Phe Asn Asn Leu Phe Arg Ile Thr Ser Asn Gly Ser Ile Tyr 
    770                 775                 780                 


Thr Ala Val Lys Leu Asn Arg Glu Val Arg Asp Tyr Tyr Glu Leu Val 
785                 790                 795                 800 


Val Val Ala Thr Asp Gly Ala Val His Pro Arg His Ser Thr Leu Thr 
                805                 810                 815     


Leu Ala Ile Lys Val Leu Asp Ile Asp Asp Asn Ser Pro Val Phe Thr 
            820                 825                 830         


Asn Ser Thr Tyr Thr Val Leu Val Glu Glu Asn Leu Pro Ala Gly Thr 
        835                 840                 845             


Thr Ile Leu Gln Ile Glu Ala Lys Asp Val Asp Leu Gly Ala Asn Val 
    850                 855                 860                 


Ser Tyr Arg Ile Arg Ser Pro Glu Val Lys His Phe Phe Ala Leu His 
865                 870                 875                 880 


Pro Phe Thr Gly Glu Leu Ser Leu Leu Arg Ser Leu Asp Tyr Glu Ala 
                885                 890                 895     


Phe Pro Asp Gln Glu Ala Ser Ile Thr Phe Leu Val Glu Ala Phe Asp 
            900                 905                 910         


Ile Tyr Gly Thr Met Pro Pro Gly Ile Ala Thr Val Thr Val Ile Val 
        915                 920                 925             


Lys Asp Met Asn Asp Tyr Pro Pro Val Phe Ser Lys Arg Ile Tyr Lys 
    930                 935                 940                 


Gly Met Val Ala Pro Asp Ala Val Lys Gly Thr Pro Ile Thr Thr Val 
945                 950                 955                 960 


Tyr Ala Glu Asp Ala Asp Pro Pro Gly Leu Pro Ala Ser Arg Val Arg 
                965                 970                 975     


Tyr Arg Val Asp Asp Val Gln Phe Pro Tyr Pro Ala Ser Ile Phe Glu 
            980                 985                 990         


Val Glu Glu Asp Ser Gly Arg Val  Ile Thr Arg Val Asn  Leu Asn Glu 
        995                 1000                 1005             


Glu Pro  Thr Thr Ile Phe Lys  Leu Val Val Val Ala  Phe Asp Asp 
    1010                 1015                 1020             


Gly Glu  Pro Val Met Ser Ser  Ser Ala Thr Val Lys  Ile Leu Val 
    1025                 1030                 1035             


Leu His  Pro Gly Glu Ile Pro  Arg Phe Thr Gln Glu  Glu Tyr Arg 
    1040                 1045                 1050             


Pro Pro  Pro Val Ser Glu Leu  Ala Thr Lys Gly Thr  Met Val Gly 
    1055                 1060                 1065             


Val Ile  Ser Ala Ala Ala Ile  Asn Gln Ser Ile Val  Tyr Ser Ile 
    1070                 1075                 1080             


Val Ser  Gly Asn Glu Glu Asp  Thr Phe Gly Ile Asn  Asn Ile Thr 
    1085                 1090                 1095             


Gly Val  Ile Tyr Val Asn Gly  Pro Leu Asp Tyr Glu  Thr Arg Thr 
    1100                 1105                 1110             


Ser Tyr  Val Leu Arg Val Gln  Ala Asp Ser Leu Glu  Val Val Leu 
    1115                 1120                 1125             


Ala Asn  Leu Arg Val Pro Ser  Lys Ser Asn Thr Ala  Lys Val Tyr 
    1130                 1135                 1140             


Ile Glu  Ile Gln Asp Glu Asn  Asn His Pro Pro Val  Phe Gln Lys 
    1145                 1150                 1155             


Lys Phe  Tyr Ile Gly Gly Val  Ser Glu Asp Ala Arg  Met Phe Thr 
    1160                 1165                 1170             


Ser Val  Leu Arg Val Lys Ala  Thr Asp Lys Asp Thr  Gly Asn Tyr 
    1175                 1180                 1185             


Ser Val  Met Ala Tyr Arg Leu  Ile Ile Pro Pro Ile  Lys Glu Gly 
    1190                 1195                 1200             


Lys Glu  Gly Phe Val Val Glu  Thr Tyr Thr Gly Leu  Ile Lys Thr 
    1205                 1210                 1215             


Ala Met  Leu Phe His Asn Met  Arg Arg Ser Tyr Phe  Lys Phe Gln 
    1220                 1225                 1230             


Val Ile  Ala Thr Asp Asp Tyr  Gly Lys Gly Leu Ser  Gly Lys Ala 
    1235                 1240                 1245             


Asp Val  Leu Val Ser Val Val  Asn Gln Leu Asp Met  Gln Val Ile 
    1250                 1255                 1260             


Val Ser  Asn Val Pro Pro Thr  Leu Val Glu Lys Lys  Ile Glu Asp 
    1265                 1270                 1275             


Leu Thr  Glu Ile Leu Asp Arg  Tyr Val Gln Glu Gln  Ile Pro Gly 
    1280                 1285                 1290             


Ala Lys  Val Val Val Glu Ser  Ile Gly Ala Arg Arg  His Gly Asp 
    1295                 1300                 1305             


Ala Phe  Ser Leu Glu Asp Tyr  Thr Lys Cys Asp Leu  Thr Val Tyr 
    1310                 1315                 1320             


Ala Ile  Asp Pro Gln Thr Asn  Arg Ala Ile Asp Arg  Asn Glu Leu 
    1325                 1330                 1335             


Phe Lys  Phe Leu Asp Gly Lys  Leu Leu Asp Ile Asn  Lys Asp Phe 
    1340                 1345                 1350             


Gln Pro  Tyr Tyr Gly Glu Gly  Gly Arg Ile Leu Glu  Ile Arg Thr 
    1355                 1360                 1365             


Pro Glu  Ala Val Thr Ser Ile  Lys Lys Arg Gly Glu  Ser Leu Gly 
    1370                 1375                 1380             


Tyr Thr  Glu Gly Ala Leu Leu  Ala Leu Ala Phe Ile  Ile Ile Leu 
    1385                 1390                 1395             


Cys Cys  Ile Pro Ala Ile Leu  Val Val Leu Val Ser  Tyr Arg Gln 
    1400                 1405                 1410             


Val Phe  Lys Gly Arg Gln Ala  Glu Cys Thr Lys Thr  Ala Arg Ile 
    1415                 1420                 1425             


Gln Ala  Ala Leu Pro Ala Ala  Lys Pro Ala Val Pro  Ala Pro Ala 
    1430                 1435                 1440             


Pro Val  Ala Ala Pro Pro Pro  Pro Pro Pro Pro Pro  Pro Gly Ala 
    1445                 1450                 1455             


His Leu  Tyr Glu Glu Leu Gly  Asp Ser Ser Met Tyr  Glu Met Pro 
    1460                 1465                 1470             


Gln Tyr  Gly Ser Arg Arg Arg  Leu Leu Pro Pro Ala  Gly Gln Glu 
    1475                 1480                 1485             


Glu Tyr  Gly Glu Val Val Gly  Glu Ala Glu Glu Glu  Tyr Glu Glu 
    1490                 1495                 1500             


Glu Glu  Glu Glu Pro Lys Lys  Ile Lys Lys Pro Lys  Val Glu Ile 
    1505                 1510                 1515             


Arg Glu  Pro Ser Glu Glu Glu  Glu Val Val Val Thr  Ile Glu Lys 
    1520                 1525                 1530             


Pro Pro  Ala Ala Glu Pro Thr  Tyr Thr Thr Trp Lys  Arg Ala Arg 
    1535                 1540                 1545             


Ile Phe  Pro Met Ile Phe Lys  Lys Val Arg Gly Leu  Ala Asp Lys 
    1550                 1555                 1560             


Arg Gly  Ile Val Asp Leu Glu  Gly Glu Glu Trp Gln  Arg Arg Leu 
    1565                 1570                 1575             


Glu Glu  Glu Asp Lys Asp Tyr  Leu Lys Leu Thr Leu  Asp Gln Glu 
    1580                 1585                 1590             


Glu Ala  Thr Glu Ser Thr Val  Glu Ser Glu Glu Glu  Ser Ser Ser 
    1595                 1600                 1605             


Asp Tyr  Thr Glu Tyr Ser Glu  Glu Glu Ser Glu Phe  Ser Glu Ser 
    1610                 1615                 1620             


Glu Thr  Thr Glu Glu Glu Ser  Glu Ser Glu Thr Pro  Ser Glu Glu 
    1625                 1630                 1635             


Glu Glu  Ser Ser Thr Pro Glu  Ser Glu Glu Ser Glu  Ser Thr Glu 
    1640                 1645                 1650             


Ser Glu  Gly Glu Lys Ala Arg  Lys Asn Ile Val Leu  Ala Arg Arg 
    1655                 1660                 1665             


Arg Pro  Met Val Glu Glu Val  Lys Glu Val Lys Gly  Arg Lys Glu 
    1670                 1675                 1680             


Glu Pro  Gln Glu Glu Gln Lys  Glu Pro Lys Met Glu  Glu Glu Glu 
    1685                 1690                 1695             


His Ser  Glu Glu Glu Glu Ser  Gly Pro Ala Pro Val  Glu Glu Ser 
    1700                 1705                 1710             


Thr Asp  Pro Glu Ala Gln Asp  Ile Pro Glu Glu Gly  Ser Ala Glu 
    1715                 1720                 1725             


Ser Ala  Ser Val Glu Gly Gly  Val Glu Ser Glu Glu  Glu Ser Glu 
    1730                 1735                 1740             


Ser Gly  Ser Ser Ser Ser Ser  Ser Glu Ser Gln Ser  Gly Gly Pro 
    1745                 1750                 1755             


Trp Gly  Tyr Gln Val Pro Ala  Tyr Asp Arg Ser Lys  Asn Ala Asn 
    1760                 1765                 1770             


Gln Lys  Lys Ser Pro Gly Ala  Asn Ser Glu Gly Tyr  Asn Thr Ala 
    1775                 1780                 1785             


Leu 
    


<210>  10077
<211>  1682
<212>  PRT
<213>  Homo Sapiens

<400>  10077

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Trp 
            20                  25                  30          


Gln Tyr Glu Asp Cys Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile 
        35                  40                  45              


Val Ala Ile Asp Glu Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn 
    50                  55                  60                  


Met Leu Ile Lys Gly Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu 
65                  70                  75                  80  


Ser Leu Lys Asp Asn Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys 
                85                  90                  95      


Gln Met Leu Phe Leu Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro 
            100                 105                 110         


Pro Met Asn Ile His Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys 
        115                 120                 125             


Lys Val Gly Thr Ile Ile Tyr His Glu Val Arg Ile Val Val Arg Asp 
    130                 135                 140                 


Arg Asn Asp Asn Ser Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr 
145                 150                 155                 160 


Val Asn Glu Leu Thr Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser 
                165                 170                 175     


Gly Asp Asn Gly Ala Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile 
            180                 185                 190         


Glu Tyr Val Ile Gln Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr 
        195                 200                 205             


Phe Glu Ile Pro Leu Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg 
    210                 215                 220                 


Leu Asn Tyr Glu Asp Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn 
225                 230                 235                 240 


Asp Arg Ala Gln Asn Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu 
                245                 250                 255     


Thr Val Asp Val Leu Asp Gly Asp Asp Leu Gly Pro Met Phe Leu Pro 
            260                 265                 270         


Cys Val Leu Val Pro Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln 
        275                 280                 285             


Ala Ala Ile Pro Glu Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile 
    290                 295                 300                 


Val Thr Pro Pro Ile Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro 
305                 310                 315                 320 


Pro Ser Asp Arg Pro Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro 
                325                 330                 335     


Glu Asp Tyr Pro Arg Phe Phe His Met His Pro Arg Thr Ala Glu Leu 
            340                 345                 350         


Ser Leu Leu Glu Pro Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu 
        355                 360                 365             


Val Ile Lys Ala Glu Gln Asp Asn Gly His Pro Leu Pro Ala Phe Ala 
    370                 375                 380                 


Gly Leu His Ile Glu Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe 
385                 390                 395                 400 


Thr Met Pro Ser Tyr Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly 
                405                 410                 415     


Ala Thr Ile Ser Asp Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val 
            420                 425                 430         


Ala Leu Asp Lys Asp Ile Glu Asp Thr Lys Asp Pro Glu Leu His Leu 
        435                 440                 445             


Phe Leu Asn Asp Tyr Thr Ser Val Phe Thr Val Thr Gln Thr Gly Ile 
    450                 455                 460                 


Thr Arg Tyr Leu Thr Leu Leu Gln Pro Val Asp Arg Glu Glu Gln Gln 
465                 470                 475                 480 


Thr Tyr Thr Phe Ser Ile Thr Ala Phe Asp Gly Val Gln Glu Ser Glu 
                485                 490                 495     


Pro Val Ile Val Asn Ile Gln Val Met Asp Ala Asn Asp Asn Thr Pro 
            500                 505                 510         


Thr Phe Pro Glu Ile Ser Tyr Asp Val Tyr Val Tyr Thr Asp Met Arg 
        515                 520                 525             


Pro Gly Asp Ser Val Ile Gln Leu Thr Ala Val Asp Ala Asp Glu Gly 
    530                 535                 540                 


Ser Asn Gly Glu Ile Thr Tyr Glu Ile Leu Val Gly Ala Gln Gly Asp 
545                 550                 555                 560 


Phe Ile Ile Asn Lys Thr Thr Gly Leu Ile Thr Ile Ala Pro Gly Val 
                565                 570                 575     


Glu Met Ile Val Gly Arg Thr Tyr Ala Leu Thr Val Gln Ala Ala Asp 
            580                 585                 590         


Asn Ala Pro Pro Ala Glu Arg Arg Asn Ser Ile Cys Thr Val Tyr Ile 
        595                 600                 605             


Glu Val Leu Pro Pro Asn Asn Gln Ser Pro Pro Arg Phe Pro Gln Leu 
    610                 615                 620                 


Met Tyr Ser Leu Glu Ile Ser Glu Ala Met Arg Val Gly Ala Val Leu 
625                 630                 635                 640 


Leu Asn Leu Gln Ala Thr Asp Arg Glu Gly Asp Ser Ile Thr Tyr Ala 
                645                 650                 655     


Ile Glu Asn Gly Asp Pro Gln Arg Val Phe Asn Leu Ser Glu Thr Thr 
            660                 665                 670         


Gly Ile Leu Thr Leu Gly Lys Ala Leu Asp Arg Glu Ser Thr Asp Arg 
        675                 680                 685             


Tyr Ile Leu Ile Ile Thr Ala Ser Asp Gly Arg Pro Asp Gly Thr Ser 
    690                 695                 700                 


Thr Ala Thr Val Asn Ile Val Val Thr Asp Val Asn Asp Asn Ala Pro 
705                 710                 715                 720 


Val Phe Asp Pro Tyr Leu Pro Arg Asn Leu Ser Val Val Glu Glu Glu 
                725                 730                 735     


Ala Asn Ala Phe Val Gly Gln Val Lys Ala Thr Asp Pro Asp Ala Gly 
            740                 745                 750         


Ile Asn Gly Gln Val His Tyr Ser Leu Gly Asn Phe Asn Asn Leu Phe 
        755                 760                 765             


Arg Ile Thr Ser Asn Gly Ser Ile Tyr Thr Ala Val Lys Leu Asn Arg 
    770                 775                 780                 


Glu Val Arg Asp Tyr Tyr Glu Leu Val Val Val Ala Thr Asp Gly Ala 
785                 790                 795                 800 


Val His Pro Arg His Ser Thr Leu Thr Leu Ala Ile Lys Val Leu Asp 
                805                 810                 815     


Ile Asp Asp Asn Ser Pro Val Phe Thr Asn Ser Thr Tyr Thr Val Leu 
            820                 825                 830         


Val Glu Glu Asn Leu Pro Ala Gly Thr Thr Ile Leu Gln Ile Glu Ala 
        835                 840                 845             


Lys Asp Val Asp Leu Gly Ala Asn Val Ser Tyr Arg Ile Arg Ser Pro 
    850                 855                 860                 


Glu Val Lys His Phe Phe Ala Leu His Pro Phe Thr Gly Glu Leu Ser 
865                 870                 875                 880 


Leu Leu Arg Ser Leu Asp Tyr Glu Ala Phe Pro Asp Gln Glu Ala Ser 
                885                 890                 895     


Ile Thr Phe Leu Val Glu Ala Phe Asp Ile Tyr Gly Thr Met Pro Pro 
            900                 905                 910         


Gly Ile Ala Thr Val Thr Val Ile Val Lys Asp Met Asn Asp Tyr Pro 
        915                 920                 925             


Pro Val Phe Ser Lys Arg Ile Tyr Lys Gly Met Val Ala Pro Asp Ala 
    930                 935                 940                 


Val Lys Gly Thr Pro Ile Thr Thr Val Tyr Ala Glu Asp Ala Asp Pro 
945                 950                 955                 960 


Pro Gly Leu Pro Ala Ser Arg Val Arg Tyr Arg Val Asp Asp Val Gln 
                965                 970                 975     


Phe Pro Tyr Pro Ala Ser Ile Phe Glu Val Glu Glu Asp Ser Gly Arg 
            980                 985                 990         


Val Ile Thr Arg Val Asn Leu Asn  Glu Glu Pro Thr Thr  Ile Phe Lys 
        995                 1000                 1005             


Leu Val  Val Val Ala Phe Asp  Asp Gly Glu Pro Val  Met Ser Ser 
    1010                 1015                 1020             


Ser Ala  Thr Val Lys Ile Leu  Val Leu His Pro Gly  Glu Ile Pro 
    1025                 1030                 1035             


Arg Phe  Thr Gln Glu Glu Tyr  Arg Pro Pro Pro Val  Ser Glu Leu 
    1040                 1045                 1050             


Ala Thr  Lys Gly Thr Met Val  Gly Val Ile Ser Ala  Ala Ala Ile 
    1055                 1060                 1065             


Asn Gln  Ser Ile Val Tyr Ser  Ile Val Ser Gly Asn  Glu Glu Asp 
    1070                 1075                 1080             


Thr Phe  Gly Ile Asn Asn Ile  Thr Gly Val Ile Tyr  Val Asn Gly 
    1085                 1090                 1095             


Pro Leu  Asp Tyr Glu Thr Arg  Thr Ser Tyr Val Leu  Arg Val Gln 
    1100                 1105                 1110             


Ala Asp  Ser Leu Glu Val Val  Leu Ala Asn Leu Arg  Val Pro Ser 
    1115                 1120                 1125             


Lys Ser  Asn Thr Ala Lys Val  Tyr Ile Glu Ile Gln  Asp Glu Asn 
    1130                 1135                 1140             


Asn His  Pro Pro Val Phe Gln  Lys Lys Phe Tyr Ile  Gly Gly Val 
    1145                 1150                 1155             


Ser Glu  Asp Ala Arg Met Phe  Thr Ser Val Leu Arg  Val Lys Ala 
    1160                 1165                 1170             


Thr Asp  Lys Asp Thr Gly Asn  Tyr Ser Val Met Ala  Tyr Arg Leu 
    1175                 1180                 1185             


Ile Ile  Pro Pro Ile Lys Glu  Gly Lys Glu Gly Phe  Val Val Glu 
    1190                 1195                 1200             


Thr Tyr  Thr Gly Leu Ile Lys  Thr Ala Met Leu Phe  His Asn Met 
    1205                 1210                 1215             


Arg Arg  Ser Tyr Phe Lys Phe  Gln Val Ile Ala Thr  Asp Asp Tyr 
    1220                 1225                 1230             


Gly Lys  Gly Leu Ser Gly Lys  Ala Asp Val Leu Val  Ser Val Val 
    1235                 1240                 1245             


Asn Gln  Leu Asp Met Gln Val  Ile Val Ser Asn Val  Pro Pro Thr 
    1250                 1255                 1260             


Leu Val  Glu Lys Lys Ile Glu  Asp Leu Thr Glu Ile  Leu Asp Arg 
    1265                 1270                 1275             


Tyr Val  Gln Glu Gln Ile Pro  Gly Ala Lys Val Val  Val Glu Ser 
    1280                 1285                 1290             


Ile Gly  Ala Arg Arg His Gly  Asp Ala Phe Ser Leu  Glu Asp Tyr 
    1295                 1300                 1305             


Thr Lys  Cys Asp Leu Thr Val  Tyr Ala Ile Asp Pro  Gln Thr Asn 
    1310                 1315                 1320             


Arg Ala  Ile Asp Arg Asn Glu  Leu Phe Lys Phe Leu  Asp Gly Lys 
    1325                 1330                 1335             


Leu Leu  Asp Ile Asn Lys Asp  Phe Gln Pro Tyr Tyr  Gly Glu Gly 
    1340                 1345                 1350             


Gly Arg  Ile Leu Glu Ile Arg  Thr Pro Glu Ala Val  Thr Ser Ile 
    1355                 1360                 1365             


Lys Lys  Arg Gly Glu Ser Leu  Gly Tyr Thr Glu Gly  Ala Leu Leu 
    1370                 1375                 1380             


Ala Leu  Ala Phe Ile Ile Ile  Leu Cys Cys Ile Pro  Ala Ile Leu 
    1385                 1390                 1395             


Val Val  Leu Val Ser Tyr Arg  Gln Phe Lys Val Arg  Gln Ala Glu 
    1400                 1405                 1410             


Cys Thr  Lys Thr Ala Arg Ile  Gln Ala Ala Leu Pro  Ala Ala Lys 
    1415                 1420                 1425             


Pro Ala  Val Pro Ala Pro Ala  Pro Val Ala Ala Pro  Pro Pro Pro 
    1430                 1435                 1440             


Pro Pro  Pro Pro Pro Gly Ala  His Leu Tyr Glu Glu  Leu Gly Asp 
    1445                 1450                 1455             


Ser Ser  Met His Lys Tyr Glu  Met Pro Gln Tyr Gly  Ser Arg Arg 
    1460                 1465                 1470             


Arg Leu  Leu Pro Pro Ala Gly  Gln Glu Glu Tyr Gly  Glu Val Val 
    1475                 1480                 1485             


Gly Glu  Ala Glu Glu Glu Tyr  Glu Glu Glu Glu Trp  Ala Arg Lys 
    1490                 1495                 1500             


Arg Met  Ile Lys Leu Val Val  Asp Arg Glu Tyr Glu  Thr Ser Ser 
    1505                 1510                 1515             


Thr Gly  Glu Asp Ser Ala Pro  Glu Cys Gln Arg Asn  Arg Leu His 
    1520                 1525                 1530             


His Pro  Ser Ile His Ser Asn  Ile Asn Gly Asn Ile  Tyr Ile Ala 
    1535                 1540                 1545             


Gln Asn  Gly Ser Val Val Arg  Thr Arg Arg Ala Cys  Leu Thr Asp 
    1550                 1555                 1560             


Asn Leu  Lys Val Ala Ser Pro  Val Arg Leu Gly Gly  Pro Phe Lys 
    1565                 1570                 1575             


Lys Leu  Asp Lys Leu Ala Val  Thr His Glu Glu Asn  Val Pro Leu 
    1580                 1585                 1590             


Asn Thr  Leu Ser Lys Gly Pro  Phe Ser Thr Glu Lys  Met Asn Ala 
    1595                 1600                 1605             


Arg Pro  Thr Leu Val Thr Phe  Ala Pro Cys Pro Val  Gly Thr Asp 
    1610                 1615                 1620             


Asn Thr  Ala Val Lys Pro Leu  Arg Asn Arg Leu Lys  Ser Thr Val 
    1625                 1630                 1635             


Glu Gln  Glu Ser Met Ile Asp  Ser Lys Asn Ile Lys  Glu Ala Leu 
    1640                 1645                 1650             


Glu Phe  His Ser Asp His Thr  Gln Ser Asp Asp Glu  Glu Leu Trp 
    1655                 1660                 1665             


Met Gly  Pro Trp Asn Asn Leu  His Ile Pro Met Thr  Lys Leu 
    1670                 1675                 1680         


<210>  10078
<211>  1964
<212>  PRT
<213>  Homo Sapiens

<400>  10078

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Trp 
            20                  25                  30          


Gln Tyr Glu Asp Cys Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile 
        35                  40                  45              


Val Ala Ile Asp Glu Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn 
    50                  55                  60                  


Met Leu Ile Lys Gly Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu 
65                  70                  75                  80  


Ser Leu Lys Asp Asn Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys 
                85                  90                  95      


Gln Met Leu Phe Leu Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro 
            100                 105                 110         


Pro Met Asn Ile His Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys 
        115                 120                 125             


Lys Val Gly Thr Ile Ile Tyr His Glu Val Arg Ile Val Val Arg Asp 
    130                 135                 140                 


Arg Asn Asp Asn Ser Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr 
145                 150                 155                 160 


Val Asn Glu Leu Thr Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser 
                165                 170                 175     


Gly Asp Asn Gly Ala Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile 
            180                 185                 190         


Glu Tyr Val Ile Gln Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr 
        195                 200                 205             


Phe Glu Ile Pro Leu Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg 
    210                 215                 220                 


Leu Asn Tyr Glu Asp Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn 
225                 230                 235                 240 


Asp Arg Ala Gln Asn Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu 
                245                 250                 255     


Thr Val Asp Val Leu Asp Gly Asp Asp Leu Gly Pro Met Phe Leu Pro 
            260                 265                 270         


Cys Val Leu Val Pro Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln 
        275                 280                 285             


Ala Ala Ile Pro Glu Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile 
    290                 295                 300                 


Val Thr Pro Pro Ile Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro 
305                 310                 315                 320 


Pro Ser Asp Arg Pro Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro 
                325                 330                 335     


Glu Asp Tyr Pro Arg Phe Phe His Met His Pro Arg Thr Ala Glu Leu 
            340                 345                 350         


Ser Leu Leu Glu Pro Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu 
        355                 360                 365             


Val Ile Lys Ala Glu Gln Asp Asn Gly His Pro Leu Pro Ala Phe Ala 
    370                 375                 380                 


Gly Leu His Ile Glu Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe 
385                 390                 395                 400 


Thr Met Pro Ser Tyr Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly 
                405                 410                 415     


Ala Thr Ile Ser Asp Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val 
            420                 425                 430         


Ala Leu Asp Lys Asp Ile Glu Asp Thr Lys Asp Pro Glu Leu His Leu 
        435                 440                 445             


Phe Leu Asn Asp Tyr Thr Ser Val Phe Thr Val Thr Gln Thr Gly Ile 
    450                 455                 460                 


Thr Arg Tyr Leu Thr Leu Leu Gln Pro Val Asp Arg Glu Glu Gln Gln 
465                 470                 475                 480 


Thr Tyr Thr Phe Ser Ile Thr Ala Phe Asp Gly Val Gln Glu Ser Glu 
                485                 490                 495     


Pro Val Ile Val Asn Ile Gln Val Met Asp Ala Asn Asp Asn Thr Pro 
            500                 505                 510         


Thr Phe Pro Glu Ile Ser Tyr Asp Val Tyr Val Tyr Thr Asp Met Arg 
        515                 520                 525             


Pro Gly Asp Ser Val Ile Gln Leu Thr Ala Val Asp Ala Asp Glu Gly 
    530                 535                 540                 


Ser Asn Gly Glu Ile Thr Tyr Glu Ile Leu Val Gly Ala Gln Gly Asp 
545                 550                 555                 560 


Phe Ile Ile Asn Lys Thr Thr Gly Leu Ile Thr Ile Ala Pro Gly Val 
                565                 570                 575     


Glu Met Ile Val Gly Arg Thr Tyr Ala Leu Thr Val Gln Ala Ala Asp 
            580                 585                 590         


Asn Ala Pro Pro Ala Glu Arg Arg Asn Ser Ile Cys Thr Val Tyr Ile 
        595                 600                 605             


Glu Val Leu Pro Pro Asn Asn Gln Ser Pro Pro Arg Phe Pro Gln Leu 
    610                 615                 620                 


Met Tyr Ser Leu Glu Ile Ser Glu Ala Met Arg Val Gly Ala Val Leu 
625                 630                 635                 640 


Leu Asn Leu Gln Ala Thr Asp Arg Glu Gly Asp Ser Ile Thr Tyr Ala 
                645                 650                 655     


Ile Glu Asn Gly Asp Pro Gln Arg Val Phe Asn Leu Ser Glu Thr Thr 
            660                 665                 670         


Gly Ile Leu Thr Leu Gly Lys Ala Leu Asp Arg Glu Ser Thr Asp Arg 
        675                 680                 685             


Tyr Ile Leu Ile Ile Thr Ala Ser Asp Gly Arg Pro Asp Gly Thr Ser 
    690                 695                 700                 


Thr Ala Thr Val Asn Ile Val Val Thr Asp Val Asn Asp Asn Ala Pro 
705                 710                 715                 720 


Val Phe Asp Pro Tyr Leu Pro Arg Asn Leu Ser Val Val Glu Glu Glu 
                725                 730                 735     


Ala Asn Ala Phe Val Gly Gln Val Lys Ala Thr Asp Pro Asp Ala Gly 
            740                 745                 750         


Ile Asn Gly Gln Val His Tyr Ser Leu Gly Asn Phe Asn Asn Leu Phe 
        755                 760                 765             


Arg Ile Thr Ser Asn Gly Ser Ile Tyr Thr Ala Val Lys Leu Asn Arg 
    770                 775                 780                 


Glu Val Arg Asp Tyr Tyr Glu Leu Val Val Val Ala Thr Asp Gly Ala 
785                 790                 795                 800 


Val His Pro Arg His Ser Thr Leu Thr Leu Ala Ile Lys Val Leu Asp 
                805                 810                 815     


Ile Asp Asp Asn Ser Pro Val Phe Thr Asn Ser Thr Tyr Thr Val Leu 
            820                 825                 830         


Val Glu Glu Asn Leu Pro Ala Gly Thr Thr Ile Leu Gln Ile Glu Ala 
        835                 840                 845             


Lys Asp Val Asp Leu Gly Ala Asn Val Ser Tyr Arg Ile Arg Ser Pro 
    850                 855                 860                 


Glu Val Lys His Phe Phe Ala Leu His Pro Phe Thr Gly Glu Leu Ser 
865                 870                 875                 880 


Leu Leu Arg Ser Leu Asp Tyr Glu Ala Phe Pro Asp Gln Glu Ala Ser 
                885                 890                 895     


Ile Thr Phe Leu Val Glu Ala Phe Asp Ile Tyr Gly Thr Met Pro Pro 
            900                 905                 910         


Gly Ile Ala Thr Val Thr Val Ile Val Lys Asp Met Asn Asp Tyr Pro 
        915                 920                 925             


Pro Val Phe Ser Lys Arg Ile Tyr Lys Gly Met Val Ala Pro Asp Ala 
    930                 935                 940                 


Val Lys Gly Thr Pro Ile Thr Thr Val Tyr Ala Glu Asp Ala Asp Pro 
945                 950                 955                 960 


Pro Gly Leu Pro Ala Ser Arg Val Arg Tyr Arg Val Asp Asp Val Gln 
                965                 970                 975     


Phe Pro Tyr Pro Ala Ser Ile Phe Glu Val Glu Glu Asp Ser Gly Arg 
            980                 985                 990         


Val Ile Thr Arg Val Asn Leu Asn  Glu Glu Pro Thr Thr  Ile Phe Lys 
        995                 1000                 1005             


Leu Val  Val Val Ala Phe Asp  Asp Gly Glu Pro Val  Met Ser Ser 
    1010                 1015                 1020             


Ser Ala  Thr Val Lys Ile Leu  Val Leu His Pro Gly  Glu Ile Pro 
    1025                 1030                 1035             


Arg Phe  Thr Gln Glu Glu Tyr  Arg Pro Pro Pro Val  Ser Glu Leu 
    1040                 1045                 1050             


Ala Thr  Lys Gly Thr Met Val  Gly Val Ile Ser Ala  Ala Ala Ile 
    1055                 1060                 1065             


Asn Gln  Ser Ile Val Tyr Ser  Ile Val Ser Gly Asn  Glu Glu Asp 
    1070                 1075                 1080             


Thr Phe  Gly Ile Asn Asn Ile  Thr Gly Val Ile Tyr  Val Asn Gly 
    1085                 1090                 1095             


Pro Leu  Asp Tyr Glu Thr Arg  Thr Ser Tyr Val Leu  Arg Val Gln 
    1100                 1105                 1110             


Ala Asp  Ser Leu Glu Val Val  Leu Ala Asn Leu Arg  Val Pro Ser 
    1115                 1120                 1125             


Lys Ser  Asn Thr Ala Lys Val  Tyr Ile Glu Ile Gln  Asp Glu Asn 
    1130                 1135                 1140             


Asn His  Pro Pro Val Phe Gln  Lys Lys Phe Tyr Ile  Gly Gly Val 
    1145                 1150                 1155             


Ser Glu  Asp Ala Arg Met Phe  Thr Ser Val Leu Arg  Val Lys Ala 
    1160                 1165                 1170             


Thr Asp  Lys Asp Thr Gly Asn  Tyr Ser Val Met Ala  Tyr Arg Leu 
    1175                 1180                 1185             


Ile Ile  Pro Pro Ile Lys Glu  Gly Lys Glu Gly Phe  Val Val Glu 
    1190                 1195                 1200             


Thr Tyr  Thr Gly Leu Ile Lys  Thr Ala Met Leu Phe  His Asn Met 
    1205                 1210                 1215             


Arg Arg  Ser Tyr Phe Lys Phe  Gln Val Ile Ala Thr  Asp Asp Tyr 
    1220                 1225                 1230             


Gly Lys  Gly Leu Ser Gly Lys  Ala Asp Val Leu Val  Ser Val Val 
    1235                 1240                 1245             


Asn Gln  Leu Asp Met Gln Val  Ile Val Ser Asn Val  Pro Pro Thr 
    1250                 1255                 1260             


Leu Val  Glu Lys Lys Ile Glu  Asp Leu Thr Glu Ile  Leu Asp Arg 
    1265                 1270                 1275             


Tyr Val  Gln Glu Gln Ile Pro  Gly Ala Lys Val Val  Val Glu Ser 
    1280                 1285                 1290             


Ile Gly  Ala Arg Arg His Gly  Asp Ala Phe Ser Leu  Glu Asp Tyr 
    1295                 1300                 1305             


Thr Lys  Cys Asp Leu Thr Val  Tyr Ala Ile Asp Pro  Gln Thr Asn 
    1310                 1315                 1320             


Arg Ala  Ile Asp Arg Asn Glu  Leu Phe Lys Phe Leu  Asp Gly Lys 
    1325                 1330                 1335             


Leu Leu  Asp Ile Asn Lys Asp  Phe Gln Pro Tyr Tyr  Gly Glu Gly 
    1340                 1345                 1350             


Gly Arg  Ile Leu Glu Ile Arg  Thr Pro Glu Ala Val  Thr Ser Ile 
    1355                 1360                 1365             


Lys Lys  Arg Gly Glu Ser Leu  Gly Tyr Thr Glu Gly  Ala Leu Leu 
    1370                 1375                 1380             


Ala Leu  Ala Phe Ile Ile Ile  Leu Cys Cys Ile Pro  Ala Ile Leu 
    1385                 1390                 1395             


Val Val  Leu Val Ser Tyr Arg  Gln Val Phe Lys Gly  Arg Gln Ala 
    1400                 1405                 1410             


Glu Cys  Thr Lys Thr Ala Arg  Ile Gln Ala Ala Leu  Pro Ala Ala 
    1415                 1420                 1425             


Lys Pro  Ala Val Pro Ala Pro  Ala Pro Val Ala Ala  Pro Pro Pro 
    1430                 1435                 1440             


Pro Pro  Pro Pro Pro Pro Gly  Ala His Leu Tyr Glu  Glu Leu Gly 
    1445                 1450                 1455             


Asp Ser  Ser Ile Leu Ser Ser  Leu Phe Leu Leu Tyr  His Phe Gln 
    1460                 1465                 1470             


Gln Ser  Arg Gly Asn Asn Ser  Val Ser Glu Asp Arg  Lys His Gln 
    1475                 1480                 1485             


Gln Val  Val Met Pro Phe Ser  Ser Asn Thr Ile Glu  Ala His Lys 
    1490                 1495                 1500             


Ser Ala  His Val Asp Gly Ser  Leu Lys Ser Asn Lys  Leu Lys Ser 
    1505                 1510                 1515             


Ala Arg  Lys Phe Thr Phe Leu  Ser Asp Glu Asp Asp  Leu Ser Ala 
    1520                 1525                 1530             


His Asn  Pro Leu Tyr Lys Glu  Asn Ile Ser Gln Val  Ser Thr Asn 
    1535                 1540                 1545             


Ser Asp  Ile Ser Gln Arg Thr  Asp Phe Val Asp Pro  Phe Ser Pro 
    1550                 1555                 1560             


Lys Ile  Gln Ala Lys Ser Lys  Ser Leu Arg Gly Pro  Arg Glu Lys 
    1565                 1570                 1575             


Ile Gln  Arg Leu Trp Ser Gln  Ser Val Ser Leu Pro  Arg Arg Leu 
    1580                 1585                 1590             


Met Arg  Lys Val Pro Asn Arg  Pro Glu Ile Ile Asp  Leu Gln Gln 
    1595                 1600                 1605             


Trp Gln  Gly Thr Arg Gln Lys  Ala Glu Asn Glu Asn  Thr Gly Ile 
    1610                 1615                 1620             


Cys Thr  Asn Lys Arg Gly Ser  Ser Asn Pro Leu Leu  Thr Thr Glu 
    1625                 1630                 1635             


Glu Ala  Asn Leu Thr Glu Lys  Glu Glu Ile Arg Gln  Gly Glu Thr 
    1640                 1645                 1650             


Leu Met  Ile Glu Gly Thr Glu  Gln Leu Lys Ser Leu  Ser Ser Asp 
    1655                 1660                 1665             


Ser Ser  Phe Cys Phe Pro Arg  Pro His Phe Ser Phe  Ser Thr Leu 
    1670                 1675                 1680             


Pro Thr  Val Ser Arg Thr Val  Glu Leu Lys Ser Glu  Pro Asn Val 
    1685                 1690                 1695             


Ile Ser  Ser Pro Ala Glu Cys  Ser Leu Glu Leu Ser  Pro Ser Arg 
    1700                 1705                 1710             


Pro Cys  Val Leu His Ser Ser  Leu Ser Arg Arg Glu  Thr Pro Ile 
    1715                 1720                 1725             


Cys Met  Leu Pro Ile Glu Thr  Glu Arg Asn Ile Phe  Glu Asn Phe 
    1730                 1735                 1740             


Ala His  Pro Pro Asn Ile Ser  Pro Ser Ala Cys Pro  Leu Pro Pro 
    1745                 1750                 1755             


Pro Pro  Pro Ile Ser Pro Pro  Ser Pro Pro Pro Ala  Pro Ala Pro 
    1760                 1765                 1770             


Leu Ala  Pro Pro Pro Asp Ile  Ser Pro Phe Ser Leu  Phe Cys Pro 
    1775                 1780                 1785             


Pro Pro  Ser Pro Pro Ser Ile  Pro Leu Pro Leu Pro  Pro Pro Thr 
    1790                 1795                 1800             


Phe Phe  Pro Leu Ser Val Ser  Thr Ser Gly Pro Pro  Thr Pro Pro 
    1805                 1810                 1815             


Leu Leu  Pro Pro Phe Pro Thr  Pro Leu Pro Pro Pro  Pro Pro Ser 
    1820                 1825                 1830             


Ile Pro  Cys Pro Pro Pro Pro  Ser Ala Ser Phe Leu  Ser Thr Glu 
    1835                 1840                 1845             


Cys Val  Cys Ile Thr Gly Val  Lys Cys Thr Thr Asn  Leu Met Pro 
    1850                 1855                 1860             


Ala Glu  Lys Ile Lys Ser Ser  Met Thr Gln Leu Ser  Thr Thr Thr 
    1865                 1870                 1875             


Val Cys  Lys Thr Asp Pro Gln  Arg Glu Pro Lys Gly  Ile Leu Arg 
    1880                 1885                 1890             


His Val  Lys Asn Leu Ala Glu  Leu Glu Lys Ser Val  Ala Asn Met 
    1895                 1900                 1905             


Tyr Ser  Gln Ile Glu Lys Asn  Tyr Leu Arg Thr Asn  Val Ser Glu 
    1910                 1915                 1920             


Leu Gln  Thr Met Cys Pro Ser  Glu Val Thr Asn Met  Glu Ile Thr 
    1925                 1930                 1935             


Ser Glu  Gln Asn Lys Gly Ser  Leu Asn Asn Ile Val  Glu Gly Thr 
    1940                 1945                 1950             


Glu Lys  Gln Ser His Ser Gln  Ser Thr Ser Leu 
    1955                 1960                 


<210>  10079
<211>  1681
<212>  PRT
<213>  Homo Sapiens

<400>  10079

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Trp 
            20                  25                  30          


Gln Tyr Glu Asp Cys Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile 
        35                  40                  45              


Val Ala Ile Asp Glu Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn 
    50                  55                  60                  


Met Leu Ile Lys Gly Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu 
65                  70                  75                  80  


Ser Leu Lys Asp Asn Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys 
                85                  90                  95      


Gln Met Leu Phe Leu Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro 
            100                 105                 110         


Pro Met Asn Ile His Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys 
        115                 120                 125             


Lys Val Gly Thr Ile Ile Tyr His Glu Val Arg Ile Val Val Arg Asp 
    130                 135                 140                 


Arg Asn Asp Asn Ser Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr 
145                 150                 155                 160 


Val Asn Glu Leu Thr Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser 
                165                 170                 175     


Gly Asp Asn Gly Ala Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile 
            180                 185                 190         


Glu Tyr Val Ile Gln Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr 
        195                 200                 205             


Phe Glu Ile Pro Leu Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg 
    210                 215                 220                 


Leu Asn Tyr Glu Asp Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn 
225                 230                 235                 240 


Asp Arg Ala Gln Asn Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu 
                245                 250                 255     


Thr Val Asp Val Leu Asp Gly Asp Asp Leu Gly Pro Met Phe Leu Pro 
            260                 265                 270         


Cys Val Leu Val Pro Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln 
        275                 280                 285             


Ala Ala Ile Pro Glu Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile 
    290                 295                 300                 


Val Thr Pro Pro Ile Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro 
305                 310                 315                 320 


Pro Ser Asp Arg Pro Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro 
                325                 330                 335     


Glu Asp Tyr Pro Arg Phe Phe His Met His Pro Arg Thr Ala Glu Leu 
            340                 345                 350         


Ser Leu Leu Glu Pro Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu 
        355                 360                 365             


Val Ile Lys Ala Glu Gln Asp Asn Gly His Pro Leu Pro Ala Phe Ala 
    370                 375                 380                 


Gly Leu His Ile Glu Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe 
385                 390                 395                 400 


Thr Met Pro Ser Tyr Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly 
                405                 410                 415     


Ala Thr Ile Ser Asp Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val 
            420                 425                 430         


Ala Leu Asp Lys Asp Ile Glu Asp Thr Lys Asp Pro Glu Leu His Leu 
        435                 440                 445             


Phe Leu Asn Asp Tyr Thr Ser Val Phe Thr Val Thr Gln Thr Gly Ile 
    450                 455                 460                 


Thr Arg Tyr Leu Thr Leu Leu Gln Pro Val Asp Arg Glu Glu Gln Gln 
465                 470                 475                 480 


Thr Tyr Thr Phe Ser Ile Thr Ala Phe Asp Gly Val Gln Glu Ser Glu 
                485                 490                 495     


Pro Val Ile Val Asn Ile Gln Val Met Asp Ala Asn Asp Asn Thr Pro 
            500                 505                 510         


Thr Phe Pro Glu Ile Ser Tyr Asp Val Tyr Val Tyr Thr Asp Met Arg 
        515                 520                 525             


Pro Gly Asp Ser Val Ile Gln Leu Thr Ala Val Asp Ala Asp Glu Gly 
    530                 535                 540                 


Ser Asn Gly Glu Ile Thr Tyr Glu Ile Leu Val Gly Ala Gln Gly Asp 
545                 550                 555                 560 


Phe Ile Ile Asn Lys Thr Thr Gly Leu Ile Thr Ile Ala Pro Gly Val 
                565                 570                 575     


Glu Met Ile Val Gly Arg Thr Tyr Ala Leu Thr Val Gln Ala Ala Asp 
            580                 585                 590         


Asn Ala Pro Pro Ala Glu Arg Arg Asn Ser Ile Cys Thr Val Tyr Ile 
        595                 600                 605             


Glu Val Leu Pro Pro Asn Asn Gln Ser Pro Pro Arg Phe Pro Gln Leu 
    610                 615                 620                 


Met Tyr Ser Leu Glu Ile Ser Glu Ala Met Arg Val Gly Ala Val Leu 
625                 630                 635                 640 


Leu Asn Leu Gln Ala Thr Asp Arg Glu Gly Asp Ser Ile Thr Tyr Ala 
                645                 650                 655     


Ile Glu Asn Gly Asp Pro Gln Arg Val Phe Asn Leu Ser Glu Thr Thr 
            660                 665                 670         


Gly Ile Leu Thr Leu Gly Lys Ala Leu Asp Arg Glu Ser Thr Asp Arg 
        675                 680                 685             


Tyr Ile Leu Ile Ile Thr Ala Ser Asp Gly Arg Pro Asp Gly Thr Ser 
    690                 695                 700                 


Thr Ala Thr Val Asn Ile Val Val Thr Asp Val Asn Asp Asn Ala Pro 
705                 710                 715                 720 


Val Phe Asp Pro Tyr Leu Pro Arg Asn Leu Ser Val Val Glu Glu Glu 
                725                 730                 735     


Ala Asn Ala Phe Val Gly Gln Val Lys Ala Thr Asp Pro Asp Ala Gly 
            740                 745                 750         


Ile Asn Gly Gln Val His Tyr Ser Leu Gly Asn Phe Asn Asn Leu Phe 
        755                 760                 765             


Arg Ile Thr Ser Asn Gly Ser Ile Tyr Thr Ala Val Lys Leu Asn Arg 
    770                 775                 780                 


Glu Val Arg Asp Tyr Tyr Glu Leu Val Val Val Ala Thr Asp Gly Ala 
785                 790                 795                 800 


Val His Pro Arg His Ser Thr Leu Thr Leu Ala Ile Lys Val Leu Asp 
                805                 810                 815     


Ile Asp Asp Asn Ser Pro Val Phe Thr Asn Ser Thr Tyr Thr Val Leu 
            820                 825                 830         


Val Glu Glu Asn Leu Pro Ala Gly Thr Thr Ile Leu Gln Ile Glu Ala 
        835                 840                 845             


Lys Asp Val Asp Leu Gly Ala Asn Val Ser Tyr Arg Ile Arg Ser Pro 
    850                 855                 860                 


Glu Val Lys His Phe Phe Ala Leu His Pro Phe Thr Gly Glu Leu Ser 
865                 870                 875                 880 


Leu Leu Arg Ser Leu Asp Tyr Glu Ala Phe Pro Asp Gln Glu Ala Ser 
                885                 890                 895     


Ile Thr Phe Leu Val Glu Ala Phe Asp Ile Tyr Gly Thr Met Pro Pro 
            900                 905                 910         


Gly Ile Ala Thr Val Thr Val Ile Val Lys Asp Met Asn Asp Tyr Pro 
        915                 920                 925             


Pro Val Phe Ser Lys Arg Ile Tyr Lys Gly Met Val Ala Pro Asp Ala 
    930                 935                 940                 


Val Lys Gly Thr Pro Ile Thr Thr Val Tyr Ala Glu Asp Ala Asp Pro 
945                 950                 955                 960 


Pro Gly Leu Pro Ala Ser Arg Val Arg Tyr Arg Val Asp Asp Val Gln 
                965                 970                 975     


Phe Pro Tyr Pro Ala Ser Ile Phe Glu Val Glu Glu Asp Ser Gly Arg 
            980                 985                 990         


Val Ile Thr Arg Val Asn Leu Asn  Glu Glu Pro Thr Thr  Ile Phe Lys 
        995                 1000                 1005             


Leu Val  Val Val Ala Phe Asp  Asp Gly Glu Pro Val  Met Ser Ser 
    1010                 1015                 1020             


Ser Ala  Thr Val Lys Ile Leu  Val Leu His Pro Gly  Glu Ile Pro 
    1025                 1030                 1035             


Arg Phe  Thr Gln Glu Glu Tyr  Arg Pro Pro Pro Val  Ser Glu Leu 
    1040                 1045                 1050             


Ala Thr  Lys Gly Thr Met Val  Gly Val Ile Ser Ala  Ala Ala Ile 
    1055                 1060                 1065             


Asn Gln  Ser Ile Val Tyr Ser  Ile Val Ser Gly Asn  Glu Glu Asp 
    1070                 1075                 1080             


Thr Phe  Gly Ile Asn Asn Ile  Thr Gly Val Ile Tyr  Val Asn Gly 
    1085                 1090                 1095             


Pro Leu  Asp Tyr Glu Thr Arg  Thr Ser Tyr Val Leu  Arg Val Gln 
    1100                 1105                 1110             


Ala Asp  Ser Leu Glu Val Val  Leu Ala Asn Leu Arg  Val Pro Ser 
    1115                 1120                 1125             


Lys Ser  Asn Thr Ala Lys Val  Tyr Ile Glu Ile Gln  Asp Glu Asn 
    1130                 1135                 1140             


Asn His  Pro Pro Val Phe Gln  Lys Lys Phe Tyr Ile  Gly Gly Val 
    1145                 1150                 1155             


Ser Glu  Asp Ala Arg Met Phe  Thr Ser Val Leu Arg  Val Lys Ala 
    1160                 1165                 1170             


Thr Asp  Lys Asp Thr Gly Asn  Tyr Ser Val Met Ala  Tyr Arg Leu 
    1175                 1180                 1185             


Ile Ile  Pro Pro Ile Lys Glu  Gly Lys Glu Gly Phe  Val Val Glu 
    1190                 1195                 1200             


Thr Tyr  Thr Gly Leu Ile Lys  Thr Ala Met Leu Phe  His Asn Met 
    1205                 1210                 1215             


Arg Arg  Ser Tyr Phe Lys Phe  Gln Val Ile Ala Thr  Asp Asp Tyr 
    1220                 1225                 1230             


Gly Lys  Gly Leu Ser Gly Lys  Ala Asp Val Leu Val  Ser Val Val 
    1235                 1240                 1245             


Asn Gln  Leu Asp Met Gln Val  Ile Val Ser Asn Val  Pro Pro Thr 
    1250                 1255                 1260             


Leu Val  Glu Lys Lys Ile Glu  Asp Leu Thr Glu Ile  Leu Asp Arg 
    1265                 1270                 1275             


Tyr Val  Gln Glu Gln Ile Pro  Gly Ala Lys Val Val  Val Glu Ser 
    1280                 1285                 1290             


Ile Gly  Ala Arg Arg His Gly  Asp Ala Phe Ser Leu  Glu Asp Tyr 
    1295                 1300                 1305             


Thr Lys  Cys Asp Leu Thr Val  Tyr Ala Ile Asp Pro  Gln Thr Asn 
    1310                 1315                 1320             


Arg Ala  Ile Asp Arg Asn Glu  Leu Phe Lys Phe Leu  Asp Gly Lys 
    1325                 1330                 1335             


Leu Leu  Asp Ile Asn Lys Asp  Phe Gln Pro Tyr Tyr  Gly Glu Gly 
    1340                 1345                 1350             


Gly Arg  Ile Leu Glu Ile Arg  Thr Pro Glu Ala Val  Thr Ser Ile 
    1355                 1360                 1365             


Lys Lys  Arg Gly Glu Ser Leu  Gly Tyr Thr Glu Gly  Ala Leu Leu 
    1370                 1375                 1380             


Ala Leu  Ala Phe Ile Ile Ile  Leu Cys Cys Ile Pro  Ala Ile Leu 
    1385                 1390                 1395             


Val Val  Leu Val Ser Tyr Arg  Gln Val Phe Lys Gly  Arg Gln Ala 
    1400                 1405                 1410             


Glu Cys  Thr Lys Thr Ala Arg  Ile Gln Ala Ala Leu  Pro Ala Ala 
    1415                 1420                 1425             


Lys Pro  Ala Val Pro Ala Pro  Ala Pro Val Ala Ala  Pro Pro Pro 
    1430                 1435                 1440             


Pro Pro  Pro Pro Pro Pro Gly  Ala His Leu Tyr Glu  Glu Leu Gly 
    1445                 1450                 1455             


Asp Ser  Ser Met Tyr Glu Met  Pro Gln Tyr Gly Ser  Arg Arg Arg 
    1460                 1465                 1470             


Leu Leu  Pro Pro Ala Gly Gln  Glu Glu Tyr Gly Glu  Val Val Gly 
    1475                 1480                 1485             


Glu Ala  Glu Glu Glu Tyr Glu  Glu Glu Glu Trp Ala  Arg Lys Arg 
    1490                 1495                 1500             


Met Ile  Lys Leu Val Val Asp  Arg Glu Tyr Glu Thr  Ser Ser Thr 
    1505                 1510                 1515             


Gly Glu  Asp Ser Ala Pro Glu  Cys Gln Arg Asn Arg  Leu His His 
    1520                 1525                 1530             


Pro Ser  Ile His Ser Asn Ile  Asn Gly Asn Ile Tyr  Ile Ala Gln 
    1535                 1540                 1545             


Asn Gly  Ser Val Val Arg Thr  Arg Arg Ala Cys Leu  Thr Asp Asn 
    1550                 1555                 1560             


Leu Lys  Val Ala Ser Pro Val  Arg Leu Gly Gly Pro  Phe Lys Lys 
    1565                 1570                 1575             


Leu Asp  Lys Leu Ala Val Thr  His Glu Glu Asn Val  Pro Leu Asn 
    1580                 1585                 1590             


Thr Leu  Ser Lys Gly Pro Phe  Ser Thr Glu Lys Met  Asn Ala Arg 
    1595                 1600                 1605             


Pro Thr  Leu Val Thr Phe Ala  Pro Cys Pro Val Gly  Thr Asp Asn 
    1610                 1615                 1620             


Thr Ala  Val Lys Pro Leu Arg  Asn Arg Leu Lys Ser  Thr Val Glu 
    1625                 1630                 1635             


Gln Glu  Ser Met Ile Asp Ser  Lys Asn Ile Lys Glu  Ala Leu Glu 
    1640                 1645                 1650             


Phe His  Ser Asp His Thr Gln  Ser Asp Asp Glu Glu  Leu Trp Met 
    1655                 1660                 1665             


Gly Pro  Trp Asn Asn Leu His  Ile Pro Met Thr Lys  Leu 
    1670                 1675                 1680     


<210>  10080
<211>  1790
<212>  PRT
<213>  Homo Sapiens

<400>  10080

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Asp Trp 
            20                  25                  30          


Gln Tyr Glu Asp Cys Lys Leu Ala Arg Gly Gly Pro Pro Ala Thr Ile 
        35                  40                  45              


Val Ala Ile Asp Glu Glu Ser Arg Asn Gly Thr Ile Leu Val Asp Asn 
    50                  55                  60                  


Met Leu Ile Lys Gly Thr Ala Gly Gly Pro Asp Pro Thr Ile Glu Leu 
65                  70                  75                  80  


Ser Leu Lys Asp Asn Val Asp Tyr Trp Val Leu Met Asp Pro Val Lys 
                85                  90                  95      


Gln Met Leu Phe Leu Asn Ser Thr Gly Arg Val Leu Asp Arg Asp Pro 
            100                 105                 110         


Pro Met Asn Ile His Ser Ile Val Val Gln Val Gln Cys Ile Asn Lys 
        115                 120                 125             


Lys Val Gly Thr Ile Ile Tyr His Glu Val Arg Ile Val Val Arg Asp 
    130                 135                 140                 


Arg Asn Asp Asn Ser Pro Thr Phe Lys His Glu Ser Tyr Tyr Ala Thr 
145                 150                 155                 160 


Val Asn Glu Leu Thr Pro Val Gly Thr Thr Ile Phe Thr Gly Phe Ser 
                165                 170                 175     


Gly Asp Asn Gly Ala Thr Asp Ile Asp Asp Gly Pro Asn Gly Gln Ile 
            180                 185                 190         


Glu Tyr Val Ile Gln Tyr Asn Pro Asp Asp Pro Thr Ser Asn Asp Thr 
        195                 200                 205             


Phe Glu Ile Pro Leu Met Leu Thr Gly Asn Ile Val Leu Arg Lys Arg 
    210                 215                 220                 


Leu Asn Tyr Glu Asp Lys Thr Arg Tyr Phe Val Ile Ile Gln Ala Asn 
225                 230                 235                 240 


Asp Arg Ala Gln Asn Leu Asn Glu Arg Arg Thr Thr Thr Thr Thr Leu 
                245                 250                 255     


Thr Val Asp Val Leu Asp Gly Asp Asp Leu Gly Pro Met Phe Leu Pro 
            260                 265                 270         


Cys Val Leu Val Pro Asn Thr Arg Asp Cys Arg Pro Leu Thr Tyr Gln 
        275                 280                 285             


Ala Ala Ile Pro Glu Leu Arg Thr Pro Glu Glu Leu Asn Pro Ile Ile 
    290                 295                 300                 


Val Thr Pro Pro Ile Gln Ala Ile Asp Gln Asp Arg Asn Ile Gln Pro 
305                 310                 315                 320 


Pro Ser Asp Arg Pro Gly Ile Leu Tyr Ser Ile Leu Val Gly Thr Pro 
                325                 330                 335     


Glu Asp Tyr Pro Arg Phe Phe His Met His Pro Arg Thr Ala Glu Leu 
            340                 345                 350         


Ser Leu Leu Glu Pro Val Asn Arg Asp Phe His Gln Lys Phe Asp Leu 
        355                 360                 365             


Val Ile Lys Ala Glu Gln Asp Asn Gly His Pro Leu Pro Ala Phe Ala 
    370                 375                 380                 


Gly Leu His Ile Glu Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe 
385                 390                 395                 400 


Thr Met Pro Ser Tyr Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly 
                405                 410                 415     


Ala Thr Ile Ser Asp Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val 
            420                 425                 430         


Ala Leu Asp Lys Asp Ile Glu Asp Val Pro Pro Ser Gly Val Pro Thr 
        435                 440                 445             


Lys Asp Pro Glu Leu His Leu Phe Leu Asn Asp Tyr Thr Ser Val Phe 
    450                 455                 460                 


Thr Val Thr Gln Thr Gly Ile Thr Arg Tyr Leu Thr Leu Leu Gln Pro 
465                 470                 475                 480 


Val Asp Arg Glu Glu Gln Gln Thr Tyr Thr Phe Ser Ile Thr Ala Phe 
                485                 490                 495     


Asp Gly Val Gln Glu Ser Glu Pro Val Ile Val Asn Ile Gln Val Met 
            500                 505                 510         


Asp Ala Asn Asp Asn Thr Pro Thr Phe Pro Glu Ile Ser Tyr Asp Val 
        515                 520                 525             


Tyr Val Tyr Thr Asp Met Arg Pro Gly Asp Ser Val Ile Gln Leu Thr 
    530                 535                 540                 


Ala Val Asp Ala Asp Glu Gly Ser Asn Gly Glu Ile Thr Tyr Glu Ile 
545                 550                 555                 560 


Leu Val Gly Ala Gln Gly Asp Phe Ile Ile Asn Lys Thr Thr Gly Leu 
                565                 570                 575     


Ile Thr Ile Ala Pro Gly Val Glu Met Ile Val Gly Arg Thr Tyr Ala 
            580                 585                 590         


Leu Thr Val Gln Ala Ala Asp Asn Ala Pro Pro Ala Glu Arg Arg Asn 
        595                 600                 605             


Ser Ile Cys Thr Val Tyr Ile Glu Val Leu Pro Pro Asn Asn Gln Ser 
    610                 615                 620                 


Pro Pro Arg Phe Pro Gln Leu Met Tyr Ser Leu Glu Ile Ser Glu Ala 
625                 630                 635                 640 


Met Arg Val Gly Ala Val Leu Leu Asn Leu Gln Ala Thr Asp Arg Glu 
                645                 650                 655     


Gly Asp Ser Ile Thr Tyr Ala Ile Glu Asn Gly Asp Pro Gln Arg Val 
            660                 665                 670         


Phe Asn Leu Ser Glu Thr Thr Gly Ile Leu Thr Leu Gly Lys Ala Leu 
        675                 680                 685             


Asp Arg Glu Ser Thr Asp Arg Tyr Ile Leu Ile Ile Thr Ala Ser Asp 
    690                 695                 700                 


Gly Arg Pro Asp Gly Thr Ser Thr Ala Thr Val Asn Ile Val Val Thr 
705                 710                 715                 720 


Asp Val Asn Asp Asn Ala Pro Val Phe Asp Pro Tyr Leu Pro Arg Asn 
                725                 730                 735     


Leu Ser Val Val Glu Glu Glu Ala Asn Ala Phe Val Gly Gln Val Lys 
            740                 745                 750         


Ala Thr Asp Pro Asp Ala Gly Ile Asn Gly Gln Val His Tyr Ser Leu 
        755                 760                 765             


Gly Asn Phe Asn Asn Leu Phe Arg Ile Thr Ser Asn Gly Ser Ile Tyr 
    770                 775                 780                 


Thr Ala Val Lys Leu Asn Arg Glu Val Arg Asp Tyr Tyr Glu Leu Val 
785                 790                 795                 800 


Val Val Ala Thr Asp Gly Ala Val His Pro Arg His Ser Thr Leu Thr 
                805                 810                 815     


Leu Ala Ile Lys Val Leu Asp Ile Asp Asp Asn Ser Pro Val Phe Thr 
            820                 825                 830         


Asn Ser Thr Tyr Thr Val Leu Val Glu Glu Asn Leu Pro Ala Gly Thr 
        835                 840                 845             


Thr Ile Leu Gln Ile Glu Ala Lys Asp Val Asp Leu Gly Ala Asn Val 
    850                 855                 860                 


Ser Tyr Arg Ile Arg Ser Pro Glu Val Lys His Phe Phe Ala Leu His 
865                 870                 875                 880 


Pro Phe Thr Gly Glu Leu Ser Leu Leu Arg Ser Leu Asp Tyr Glu Ala 
                885                 890                 895     


Phe Pro Asp Gln Glu Ala Ser Ile Thr Phe Leu Val Glu Ala Phe Asp 
            900                 905                 910         


Ile Tyr Gly Thr Met Pro Pro Gly Ile Ala Thr Val Thr Val Ile Val 
        915                 920                 925             


Lys Asp Met Asn Asp Tyr Pro Pro Val Phe Ser Lys Arg Ile Tyr Lys 
    930                 935                 940                 


Gly Met Val Ala Pro Asp Ala Val Lys Gly Thr Pro Ile Thr Thr Val 
945                 950                 955                 960 


Tyr Ala Glu Asp Ala Asp Pro Pro Gly Leu Pro Ala Ser Arg Val Arg 
                965                 970                 975     


Tyr Arg Val Asp Asp Val Gln Phe Pro Tyr Pro Ala Ser Ile Phe Glu 
            980                 985                 990         


Val Glu Glu Asp Ser Gly Arg Val  Ile Thr Arg Val Asn  Leu Asn Glu 
        995                 1000                 1005             


Glu Pro  Thr Thr Ile Phe Lys  Leu Val Val Val Ala  Phe Asp Asp 
    1010                 1015                 1020             


Gly Glu  Pro Val Met Ser Ser  Ser Ala Thr Val Lys  Ile Leu Val 
    1025                 1030                 1035             


Leu His  Pro Gly Glu Ile Pro  Arg Phe Thr Gln Glu  Glu Tyr Arg 
    1040                 1045                 1050             


Pro Pro  Pro Val Ser Glu Leu  Ala Thr Lys Gly Thr  Met Val Gly 
    1055                 1060                 1065             


Val Ile  Ser Ala Ala Ala Ile  Asn Gln Ser Ile Val  Tyr Ser Ile 
    1070                 1075                 1080             


Val Ser  Gly Asn Glu Glu Asp  Thr Phe Gly Ile Asn  Asn Ile Thr 
    1085                 1090                 1095             


Gly Val  Ile Tyr Val Asn Gly  Pro Leu Asp Tyr Glu  Thr Arg Thr 
    1100                 1105                 1110             


Ser Tyr  Val Leu Arg Val Gln  Ala Asp Ser Leu Glu  Val Val Leu 
    1115                 1120                 1125             


Ala Asn  Leu Arg Val Pro Ser  Lys Ser Asn Thr Ala  Lys Val Tyr 
    1130                 1135                 1140             


Ile Glu  Ile Gln Asp Glu Asn  Asn His Pro Pro Val  Phe Gln Lys 
    1145                 1150                 1155             


Lys Phe  Tyr Ile Gly Gly Val  Ser Glu Asp Ala Arg  Met Phe Thr 
    1160                 1165                 1170             


Ser Val  Leu Arg Val Lys Ala  Thr Asp Lys Asp Thr  Gly Asn Tyr 
    1175                 1180                 1185             


Ser Val  Met Ala Tyr Arg Leu  Ile Ile Pro Pro Ile  Lys Glu Gly 
    1190                 1195                 1200             


Lys Glu  Gly Phe Val Val Glu  Thr Tyr Thr Gly Leu  Ile Lys Thr 
    1205                 1210                 1215             


Ala Met  Leu Phe His Asn Met  Arg Arg Ser Tyr Phe  Lys Phe Gln 
    1220                 1225                 1230             


Val Ile  Ala Thr Asp Asp Tyr  Gly Lys Gly Leu Ser  Gly Lys Ala 
    1235                 1240                 1245             


Asp Val  Leu Val Ser Val Val  Asn Gln Leu Asp Met  Gln Val Ile 
    1250                 1255                 1260             


Val Ser  Asn Val Pro Pro Thr  Leu Val Glu Lys Lys  Ile Glu Asp 
    1265                 1270                 1275             


Leu Thr  Glu Ile Leu Asp Arg  Tyr Val Gln Glu Gln  Ile Pro Gly 
    1280                 1285                 1290             


Ala Lys  Val Val Val Glu Ser  Ile Gly Ala Arg Arg  His Gly Asp 
    1295                 1300                 1305             


Ala Phe  Ser Leu Glu Asp Tyr  Thr Lys Cys Asp Leu  Thr Val Tyr 
    1310                 1315                 1320             


Ala Ile  Asp Pro Gln Thr Asn  Arg Ala Ile Asp Arg  Asn Glu Leu 
    1325                 1330                 1335             


Phe Lys  Phe Leu Asp Gly Lys  Leu Leu Asp Ile Asn  Lys Asp Phe 
    1340                 1345                 1350             


Gln Pro  Tyr Tyr Gly Glu Gly  Gly Arg Ile Leu Glu  Ile Arg Thr 
    1355                 1360                 1365             


Pro Glu  Ala Val Thr Ser Ile  Lys Lys Arg Gly Glu  Ser Leu Gly 
    1370                 1375                 1380             


Tyr Thr  Glu Gly Ala Leu Leu  Ala Leu Ala Phe Ile  Ile Ile Leu 
    1385                 1390                 1395             


Cys Cys  Ile Pro Ala Ile Leu  Val Val Leu Val Ser  Tyr Arg Gln 
    1400                 1405                 1410             


Phe Lys  Val Arg Gln Ala Glu  Cys Thr Lys Thr Ala  Arg Ile Gln 
    1415                 1420                 1425             


Ala Ala  Leu Pro Ala Ala Lys  Pro Ala Val Pro Ala  Pro Ala Pro 
    1430                 1435                 1440             


Val Ala  Ala Pro Pro Pro Pro  Pro Pro Pro Pro Pro  Gly Ala His 
    1445                 1450                 1455             


Leu Tyr  Glu Glu Leu Gly Asp  Ser Ser Met His Lys  Tyr Glu Met 
    1460                 1465                 1470             


Pro Gln  Tyr Gly Ser Arg Arg  Arg Leu Leu Pro Pro  Ala Gly Gln 
    1475                 1480                 1485             


Glu Glu  Tyr Gly Glu Val Val  Gly Glu Ala Glu Glu  Glu Tyr Glu 
    1490                 1495                 1500             


Glu Glu  Glu Glu Glu Pro Lys  Lys Ile Lys Lys Pro  Lys Val Glu 
    1505                 1510                 1515             


Ile Arg  Glu Pro Ser Glu Glu  Glu Glu Val Val Val  Thr Ile Glu 
    1520                 1525                 1530             


Lys Pro  Pro Ala Ala Glu Pro  Thr Tyr Thr Thr Trp  Lys Arg Ala 
    1535                 1540                 1545             


Arg Ile  Phe Pro Met Ile Phe  Lys Lys Val Arg Gly  Leu Ala Asp 
    1550                 1555                 1560             


Lys Arg  Gly Ile Val Asp Leu  Glu Gly Glu Glu Trp  Gln Arg Arg 
    1565                 1570                 1575             


Leu Glu  Glu Glu Asp Lys Asp  Tyr Leu Lys Leu Thr  Leu Asp Gln 
    1580                 1585                 1590             


Glu Glu  Ala Thr Glu Ser Thr  Val Glu Ser Glu Glu  Glu Ser Ser 
    1595                 1600                 1605             


Ser Asp  Tyr Thr Glu Tyr Ser  Glu Glu Glu Ser Glu  Phe Ser Glu 
    1610                 1615                 1620             


Ser Glu  Thr Thr Glu Glu Glu  Ser Glu Ser Glu Thr  Pro Ser Glu 
    1625                 1630                 1635             


Glu Glu  Glu Ser Ser Thr Pro  Glu Ser Glu Glu Ser  Glu Ser Thr 
    1640                 1645                 1650             


Glu Ser  Glu Gly Glu Lys Ala  Arg Lys Asn Ile Val  Leu Ala Arg 
    1655                 1660                 1665             


Arg Arg  Pro Met Val Glu Glu  Val Lys Glu Val Lys  Gly Arg Lys 
    1670                 1675                 1680             


Glu Glu  Pro Gln Glu Glu Gln  Lys Glu Pro Lys Met  Glu Glu Glu 
    1685                 1690                 1695             


Glu His  Ser Glu Glu Glu Glu  Ser Gly Pro Ala Pro  Val Glu Glu 
    1700                 1705                 1710             


Ser Thr  Asp Pro Glu Ala Gln  Asp Ile Pro Glu Glu  Gly Ser Ala 
    1715                 1720                 1725             


Glu Ser  Ala Ser Val Glu Gly  Gly Val Glu Ser Glu  Glu Glu Ser 
    1730                 1735                 1740             


Glu Ser  Gly Ser Ser Ser Ser  Ser Ser Glu Ser Gln  Ser Gly Gly 
    1745                 1750                 1755             


Pro Trp  Gly Tyr Gln Val Pro  Ala Tyr Asp Arg Ser  Lys Asn Ala 
    1760                 1765                 1770             


Asn Gln  Lys Lys Ser Pro Gly  Ala Asn Ser Glu Gly  Tyr Asn Thr 
    1775                 1780                 1785             


Ala Leu  
    1790 


<210>  10081
<211>  72
<212>  PRT
<213>  Homo Sapiens

<400>  10081

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Gly Thr 
            20                  25                  30          


Ile Leu Val Asp Asn Met Leu Ile Lys Gly Thr Ala Gly Gly Pro Asp 
        35                  40                  45              


Pro Thr Ile Glu Leu Ser Leu Lys Asp Asn Val Asp Tyr Trp Val Leu 
    50                  55                  60                  


Met Asp Pro Val Lys Gln Met Leu 
65                  70          


<210>  10082
<211>  1932
<212>  PRT
<213>  Homo Sapiens

<400>  10082

Met Phe Arg Gln Phe Tyr Leu Trp Thr Cys Leu Ala Ser Gly Ile Ile 
1               5                   10                  15      


Leu Gly Ser Leu Phe Glu Ile Cys Leu Gly Gln Tyr Asp Asp Gly Thr 
            20                  25                  30          


Ile Leu Val Asp Asn Met Leu Ile Lys Gly Thr Ala Gly Gly Pro Asp 
        35                  40                  45              


Pro Thr Ile Glu Leu Ser Leu Lys Asp Asn Val Asp Tyr Trp Val Leu 
    50                  55                  60                  


Met Asp Pro Val Lys Gln Met Leu Phe Leu Asn Ser Thr Gly Arg Val 
65                  70                  75                  80  


Leu Asp Arg Asp Pro Pro Met Asn Ile His Ser Ile Val Val Gln Val 
                85                  90                  95      


Gln Cys Ile Asn Lys Lys Val Gly Thr Ile Ile Tyr His Glu Val Arg 
            100                 105                 110         


Ile Val Val Arg Asp Arg Asn Asp Asn Ser Pro Thr Phe Lys His Glu 
        115                 120                 125             


Ser Tyr Tyr Ala Thr Val Asn Glu Leu Thr Pro Val Gly Thr Thr Ile 
    130                 135                 140                 


Phe Thr Gly Phe Ser Gly Asp Asn Gly Ala Thr Asp Ile Asp Asp Gly 
145                 150                 155                 160 


Pro Asn Gly Gln Ile Glu Tyr Val Ile Gln Tyr Asn Pro Asp Asp Pro 
                165                 170                 175     


Thr Ser Asn Asp Thr Phe Glu Ile Pro Leu Met Leu Thr Gly Asn Ile 
            180                 185                 190         


Val Leu Arg Lys Arg Leu Asn Tyr Glu Asp Lys Thr Arg Tyr Phe Val 
        195                 200                 205             


Ile Ile Gln Ala Asn Asp Arg Ala Gln Asn Leu Asn Glu Arg Arg Thr 
    210                 215                 220                 


Thr Thr Thr Thr Leu Thr Val Asp Val Leu Asp Gly Asp Asp Leu Gly 
225                 230                 235                 240 


Pro Met Phe Leu Pro Cys Val Leu Val Pro Asn Thr Arg Asp Cys Arg 
                245                 250                 255     


Pro Leu Thr Tyr Gln Ala Ala Ile Pro Glu Leu Arg Thr Pro Glu Glu 
            260                 265                 270         


Leu Asn Pro Ile Ile Val Thr Pro Pro Ile Gln Ala Ile Asp Gln Asp 
        275                 280                 285             


Arg Asn Ile Gln Pro Pro Ser Asp Arg Pro Gly Ile Leu Tyr Ser Ile 
    290                 295                 300                 


Leu Val Gly Thr Pro Glu Asp Tyr Pro Arg Phe Phe His Met His Pro 
305                 310                 315                 320 


Arg Thr Ala Glu Leu Ser Leu Leu Glu Pro Val Asn Arg Asp Phe His 
                325                 330                 335     


Gln Lys Phe Asp Leu Val Ile Lys Ala Glu Gln Asp Asn Gly His Pro 
            340                 345                 350         


Leu Pro Ala Phe Ala Gly Leu His Ile Glu Ile Leu Asp Glu Asn Asn 
        355                 360                 365             


Gln Ser Pro Tyr Phe Thr Met Pro Ser Tyr Gln Gly Tyr Ile Leu Glu 
    370                 375                 380                 


Ser Ala Pro Val Gly Ala Thr Ile Ser Asp Ser Leu Asn Leu Thr Ser 
385                 390                 395                 400 


Pro Leu Arg Ile Val Ala Leu Asp Lys Asp Ile Glu Asp Thr Lys Asp 
                405                 410                 415     


Pro Glu Leu His Leu Phe Leu Asn Asp Tyr Thr Ser Val Phe Thr Val 
            420                 425                 430         


Thr Gln Thr Gly Ile Thr Arg Tyr Leu Thr Leu Leu Gln Pro Val Asp 
        435                 440                 445             


Arg Glu Glu Gln Gln Thr Tyr Thr Phe Ser Ile Thr Ala Phe Asp Gly 
    450                 455                 460                 


Val Gln Glu Ser Glu Pro Val Ile Val Asn Ile Gln Val Met Asp Ala 
465                 470                 475                 480 


Asn Asp Asn Thr Pro Thr Phe Pro Glu Ile Ser Tyr Asp Val Tyr Val 
                485                 490                 495     


Tyr Thr Asp Met Arg Pro Gly Asp Ser Val Ile Gln Leu Thr Ala Val 
            500                 505                 510         


Asp Ala Asp Glu Gly Ser Asn Gly Glu Ile Thr Tyr Glu Ile Leu Val 
        515                 520                 525             


Gly Ala Gln Gly Asp Phe Ile Ile Asn Lys Thr Thr Gly Leu Ile Thr 
    530                 535                 540                 


Ile Ala Pro Gly Val Glu Met Ile Val Gly Arg Thr Tyr Ala Leu Thr 
545                 550                 555                 560 


Val Gln Ala Ala Asp Asn Ala Pro Pro Ala Glu Arg Arg Asn Ser Ile 
                565                 570                 575     


Cys Thr Val Tyr Ile Glu Val Leu Pro Pro Asn Asn Gln Ser Pro Pro 
            580                 585                 590         


Arg Phe Pro Gln Leu Met Tyr Ser Leu Glu Ile Ser Glu Ala Met Arg 
        595                 600                 605             


Val Gly Ala Val Leu Leu Asn Leu Gln Ala Thr Asp Arg Glu Gly Asp 
    610                 615                 620                 


Ser Ile Thr Tyr Ala Ile Glu Asn Gly Asp Pro Gln Arg Val Phe Asn 
625                 630                 635                 640 


Leu Ser Glu Thr Thr Gly Ile Leu Thr Leu Gly Lys Ala Leu Asp Arg 
                645                 650                 655     


Glu Ser Thr Asp Arg Tyr Ile Leu Ile Ile Thr Ala Ser Asp Gly Arg 
            660                 665                 670         


Pro Asp Gly Thr Ser Thr Ala Thr Val Asn Ile Val Val Thr Asp Val 
        675                 680                 685             


Asn Asp Asn Ala Pro Val Phe Asp Pro Tyr Leu Pro Arg Asn Leu Ser 
    690                 695                 700                 


Val Val Glu Glu Glu Ala Asn Ala Phe Val Gly Gln Val Lys Ala Thr 
705                 710                 715                 720 


Asp Pro Asp Ala Gly Ile Asn Gly Gln Val His Tyr Ser Leu Gly Asn 
                725                 730                 735     


Phe Asn Asn Leu Phe Arg Ile Thr Ser Asn Gly Ser Ile Tyr Thr Ala 
            740                 745                 750         


Val Lys Leu Asn Arg Glu Val Arg Asp Tyr Tyr Glu Leu Val Val Val 
        755                 760                 765             


Ala Thr Asp Gly Ala Val His Pro Arg His Ser Thr Leu Thr Leu Ala 
    770                 775                 780                 


Ile Lys Val Leu Asp Ile Asp Asp Asn Ser Pro Val Phe Thr Asn Ser 
785                 790                 795                 800 


Thr Tyr Thr Val Leu Val Glu Glu Asn Leu Pro Ala Gly Thr Thr Ile 
                805                 810                 815     


Leu Gln Ile Glu Ala Lys Asp Val Asp Leu Gly Ala Asn Val Ser Tyr 
            820                 825                 830         


Arg Ile Arg Ser Pro Glu Val Lys His Phe Phe Ala Leu His Pro Phe 
        835                 840                 845             


Thr Gly Glu Leu Ser Leu Leu Arg Ser Leu Asp Tyr Glu Ala Phe Pro 
    850                 855                 860                 


Asp Gln Glu Ala Ser Ile Thr Phe Leu Val Glu Ala Phe Asp Ile Tyr 
865                 870                 875                 880 


Gly Thr Met Pro Pro Gly Ile Ala Thr Val Thr Val Ile Val Lys Asp 
                885                 890                 895     


Met Asn Asp Tyr Pro Pro Val Phe Ser Lys Arg Ile Tyr Lys Gly Met 
            900                 905                 910         


Val Ala Pro Asp Ala Val Lys Gly Thr Pro Ile Thr Thr Val Tyr Ala 
        915                 920                 925             


Glu Asp Ala Asp Pro Pro Gly Leu Pro Ala Ser Arg Val Arg Tyr Arg 
    930                 935                 940                 


Val Asp Asp Val Gln Phe Pro Tyr Pro Ala Ser Ile Phe Glu Val Glu 
945                 950                 955                 960 


Glu Asp Ser Gly Arg Val Ile Thr Arg Val Asn Leu Asn Glu Glu Pro 
                965                 970                 975     


Thr Thr Ile Phe Lys Leu Val Val Val Ala Phe Asp Asp Gly Glu Pro 
            980                 985                 990         


Val Met Ser Ser Ser Ala Thr Val  Lys Ile Leu Val Leu  His Pro Gly 
        995                 1000                 1005             


Glu Ile  Pro Arg Phe Thr Gln  Glu Glu Tyr Arg Pro  Pro Pro Val 
    1010                 1015                 1020             


Ser Glu  Leu Ala Thr Lys Gly  Thr Met Val Gly Val  Ile Ser Ala 
    1025                 1030                 1035             


Ala Ala  Ile Asn Gln Ser Ile  Val Tyr Ser Ile Val  Ser Gly Asn 
    1040                 1045                 1050             


Glu Glu  Asp Thr Phe Gly Ile  Asn Asn Ile Thr Gly  Val Ile Tyr 
    1055                 1060                 1065             


Val Asn  Gly Pro Leu Asp Tyr  Glu Thr Arg Thr Ser  Tyr Val Leu 
    1070                 1075                 1080             


Arg Val  Gln Ala Asp Ser Leu  Glu Val Val Leu Ala  Asn Leu Arg 
    1085                 1090                 1095             


Val Pro  Ser Lys Ser Asn Thr  Ala Lys Val Tyr Ile  Glu Ile Gln 
    1100                 1105                 1110             


Asp Glu  Asn Asn His Pro Pro  Val Phe Gln Lys Lys  Phe Tyr Ile 
    1115                 1120                 1125             


Gly Gly  Val Ser Glu Asp Ala  Arg Met Phe Thr Ser  Val Leu Arg 
    1130                 1135                 1140             


Val Lys  Ala Thr Asp Lys Asp  Thr Gly Asn Tyr Ser  Val Met Ala 
    1145                 1150                 1155             


Tyr Arg  Leu Ile Ile Pro Pro  Ile Lys Glu Gly Lys  Glu Gly Phe 
    1160                 1165                 1170             


Val Val  Glu Thr Tyr Thr Gly  Leu Ile Lys Thr Ala  Met Leu Phe 
    1175                 1180                 1185             


His Asn  Met Arg Arg Ser Tyr  Phe Lys Phe Gln Val  Ile Ala Thr 
    1190                 1195                 1200             


Asp Asp  Tyr Gly Lys Gly Leu  Ser Gly Lys Ala Asp  Val Leu Val 
    1205                 1210                 1215             


Ser Val  Val Asn Gln Leu Asp  Met Gln Val Ile Val  Ser Asn Val 
    1220                 1225                 1230             


Pro Pro  Thr Leu Val Glu Lys  Lys Ile Glu Asp Leu  Thr Glu Ile 
    1235                 1240                 1245             


Leu Asp  Arg Tyr Val Gln Glu  Gln Ile Pro Gly Ala  Lys Val Val 
    1250                 1255                 1260             


Val Glu  Ser Ile Gly Ala Arg  Arg His Gly Asp Ala  Phe Ser Leu 
    1265                 1270                 1275             


Glu Asp  Tyr Thr Lys Cys Asp  Leu Thr Val Tyr Ala  Ile Asp Pro 
    1280                 1285                 1290             


Gln Thr  Asn Arg Ala Ile Asp  Arg Asn Glu Leu Phe  Lys Phe Leu 
    1295                 1300                 1305             


Asp Gly  Lys Leu Leu Asp Ile  Asn Lys Asp Phe Gln  Pro Tyr Tyr 
    1310                 1315                 1320             


Gly Glu  Gly Gly Arg Ile Leu  Glu Ile Arg Thr Pro  Glu Ala Val 
    1325                 1330                 1335             


Thr Ser  Ile Lys Lys Arg Gly  Glu Ser Leu Gly Tyr  Thr Glu Gly 
    1340                 1345                 1350             


Ala Leu  Leu Ala Leu Ala Phe  Ile Ile Ile Leu Cys  Cys Ile Pro 
    1355                 1360                 1365             


Ala Ile  Leu Val Val Leu Val  Ser Tyr Arg Gln Arg  Gln Ala Glu 
    1370                 1375                 1380             


Cys Thr  Lys Thr Ala Arg Ile  Gln Ala Ala Leu Pro  Ala Ala Lys 
    1385                 1390                 1395             


Pro Ala  Val Pro Ala Pro Ala  Pro Val Ala Ala Pro  Pro Pro Pro 
    1400                 1405                 1410             


Pro Pro  Pro Pro Pro Gly Ala  His Leu Tyr Glu Glu  Leu Gly Asp 
    1415                 1420                 1425             


Ser Ser  Met His Asn Leu Phe  Leu Leu Tyr His Phe  Gln Gln Ser 
    1430                 1435                 1440             


Arg Gly  Asn Asn Ser Val Ser  Glu Asp Arg Lys His  Gln Gln Val 
    1445                 1450                 1455             


Val Met  Pro Phe Ser Ser Asn  Thr Ile Glu Ala His  Lys Ser Ala 
    1460                 1465                 1470             


His Val  Asp Gly Ser Leu Lys  Ser Asn Lys Leu Lys  Ser Ala Arg 
    1475                 1480                 1485             


Lys Phe  Thr Phe Leu Ser Asp  Glu Asp Asp Leu Ser  Ala His Asn 
    1490                 1495                 1500             


Pro Leu  Tyr Lys Glu Asn Ile  Ser Gln Val Ser Thr  Asn Ser Asp 
    1505                 1510                 1515             


Ile Ser  Gln Arg Thr Asp Phe  Val Asp Pro Phe Ser  Pro Lys Ile 
    1520                 1525                 1530             


Gln Ala  Lys Ser Lys Ser Leu  Arg Gly Pro Arg Glu  Lys Ile Gln 
    1535                 1540                 1545             


Arg Leu  Trp Ser Gln Ser Val  Ser Leu Pro Arg Arg  Leu Met Arg 
    1550                 1555                 1560             


Lys Val  Pro Asn Arg Pro Glu  Ile Ile Asp Leu Gln  Gln Trp Gln 
    1565                 1570                 1575             


Gly Thr  Arg Gln Lys Ala Glu  Asn Glu Asn Thr Gly  Ile Cys Thr 
    1580                 1585                 1590             


Asn Lys  Arg Gly Ser Ser Asn  Pro Leu Leu Thr Thr  Glu Glu Ala 
    1595                 1600                 1605             


Asn Leu  Thr Glu Lys Glu Glu  Ile Arg Gln Gly Glu  Thr Leu Met 
    1610                 1615                 1620             


Ile Glu  Gly Thr Glu Gln Leu  Lys Ser Leu Ser Ser  Asp Ser Ser 
    1625                 1630                 1635             


Phe Cys  Phe Pro Arg Pro His  Phe Ser Phe Ser Thr  Leu Pro Thr 
    1640                 1645                 1650             


Val Ser  Arg Thr Val Glu Leu  Lys Ser Glu Pro Asn  Val Ile Ser 
    1655                 1660                 1665             


Ser Pro  Ala Glu Cys Ser Leu  Glu Leu Ser Pro Ser  Arg Pro Cys 
    1670                 1675                 1680             


Val Leu  His Ser Ser Leu Ser  Arg Arg Glu Thr Pro  Ile Cys Met 
    1685                 1690                 1695             


Leu Pro  Ile Glu Thr Glu Arg  Asn Ile Phe Glu Asn  Phe Ala His 
    1700                 1705                 1710             


Pro Pro  Asn Ile Ser Pro Ser  Ala Cys Pro Leu Pro  Pro Pro Pro 
    1715                 1720                 1725             


Pro Ile  Ser Pro Pro Ser Pro  Pro Pro Ala Pro Ala  Pro Leu Ala 
    1730                 1735                 1740             


Pro Pro  Pro Asp Ile Ser Pro  Phe Ser Leu Phe Cys  Pro Pro Pro 
    1745                 1750                 1755             


Ser Pro  Pro Ser Ile Pro Leu  Pro Leu Pro Pro Pro  Thr Phe Phe 
    1760                 1765                 1770             


Pro Leu  Ser Val Ser Thr Ser  Gly Pro Pro Thr Pro  Pro Leu Leu 
    1775                 1780                 1785             


Pro Pro  Phe Pro Thr Pro Leu  Pro Pro Pro Pro Pro  Ser Ile Pro 
    1790                 1795                 1800             


Cys Pro  Pro Pro Pro Ser Ala  Ser Phe Leu Ser Thr  Glu Cys Val 
    1805                 1810                 1815             


Cys Ile  Thr Gly Val Lys Cys  Thr Thr Asn Leu Met  Pro Ala Glu 
    1820                 1825                 1830             


Lys Ile  Lys Ser Ser Met Thr  Gln Leu Ser Thr Thr  Thr Val Cys 
    1835                 1840                 1845             


Lys Thr  Asp Pro Gln Arg Glu  Pro Lys Gly Ile Leu  Arg His Val 
    1850                 1855                 1860             


Lys Asn  Leu Ala Glu Leu Glu  Lys Ser Val Ala Asn  Met Tyr Ser 
    1865                 1870                 1875             


Gln Ile  Glu Lys Asn Tyr Leu  Arg Thr Asn Val Ser  Glu Leu Gln 
    1880                 1885                 1890             


Thr Met  Cys Pro Ser Glu Val  Thr Asn Met Glu Ile  Thr Ser Glu 
    1895                 1900                 1905             


Gln Asn  Lys Gly Ser Leu Asn  Asn Ile Val Glu Gly  Thr Glu Lys 
    1910                 1915                 1920             


Gln Ser  His Ser Gln Ser Thr  Ser Leu 
    1925                 1930         


<210>  10083
<211>  1150
<212>  PRT
<213>  Homo Sapiens

<400>  10083

Met Pro Ser Tyr Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly Ala 
1               5                   10                  15      


Thr Ile Ser Asp Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val Ala 
            20                  25                  30          


Leu Asp Lys Asp Ile Glu Asp Val Pro Pro Ser Gly Val Pro Thr Lys 
        35                  40                  45              


Asp Pro Glu Leu His Leu Phe Leu Asn Asp Tyr Thr Ser Val Phe Thr 
    50                  55                  60                  


Val Thr Gln Thr Gly Ile Thr Arg Tyr Leu Thr Leu Leu Gln Pro Val 
65                  70                  75                  80  


Asp Arg Glu Glu Gln Gln Thr Tyr Thr Phe Ser Ile Thr Ala Phe Asp 
                85                  90                  95      


Gly Val Gln Glu Ser Glu Pro Val Ile Val Asn Ile Gln Val Met Asp 
            100                 105                 110         


Ala Asn Asp Asn Thr Pro Thr Phe Pro Glu Ile Ser Tyr Asp Val Tyr 
        115                 120                 125             


Val Tyr Thr Asp Met Arg Pro Gly Asp Ser Val Ile Gln Leu Thr Ala 
    130                 135                 140                 


Val Asp Ala Asp Glu Gly Ser Asn Gly Glu Ile Thr Tyr Glu Ile Leu 
145                 150                 155                 160 


Val Gly Ala Gln Gly Asp Phe Ile Ile Asn Lys Thr Thr Gly Leu Ile 
                165                 170                 175     


Thr Ile Ala Pro Gly Val Glu Met Ile Val Gly Arg Thr Tyr Ala Leu 
            180                 185                 190         


Thr Val Gln Ala Ala Asp Asn Ala Pro Pro Ala Glu Arg Arg Asn Ser 
        195                 200                 205             


Ile Cys Thr Val Tyr Ile Glu Val Leu Pro Pro Asn Asn Gln Ser Pro 
    210                 215                 220                 


Pro Arg Phe Pro Gln Leu Met Tyr Ser Leu Glu Ile Ser Glu Ala Met 
225                 230                 235                 240 


Arg Val Gly Ala Val Leu Leu Asn Leu Gln Ala Thr Asp Arg Glu Gly 
                245                 250                 255     


Asp Ser Ile Thr Tyr Ala Ile Glu Asn Gly Asp Pro Gln Arg Val Phe 
            260                 265                 270         


Asn Leu Ser Glu Thr Thr Gly Ile Leu Thr Leu Gly Lys Ala Leu Asp 
        275                 280                 285             


Arg Glu Ser Thr Asp Arg Tyr Ile Leu Ile Ile Thr Ala Ser Asp Gly 
    290                 295                 300                 


Arg Pro Asp Gly Thr Ser Thr Ala Thr Val Asn Ile Val Val Thr Asp 
305                 310                 315                 320 


Val Asn Asp Asn Ala Pro Val Phe Asp Pro Tyr Leu Pro Arg Asn Leu 
                325                 330                 335     


Ser Val Val Glu Glu Glu Ala Asn Ala Phe Val Gly Gln Val Lys Ala 
            340                 345                 350         


Thr Asp Pro Asp Ala Gly Ile Asn Gly Gln Val His Tyr Ser Leu Gly 
        355                 360                 365             


Asn Phe Asn Asn Leu Phe Arg Ile Thr Ser Asn Gly Ser Ile Tyr Thr 
    370                 375                 380                 


Ala Val Lys Leu Asn Arg Glu Val Arg Asp Tyr Tyr Glu Leu Val Val 
385                 390                 395                 400 


Val Ala Thr Asp Gly Ala Val His Pro Arg His Ser Thr Leu Thr Leu 
                405                 410                 415     


Ala Ile Lys Val Leu Asp Ile Asp Asp Asn Ser Pro Val Phe Thr Asn 
            420                 425                 430         


Ser Thr Tyr Thr Val Leu Val Glu Glu Asn Leu Pro Ala Gly Thr Thr 
        435                 440                 445             


Ile Leu Gln Ile Glu Ala Lys Asp Val Asp Leu Gly Ala Asn Val Ser 
    450                 455                 460                 


Tyr Arg Ile Arg Ser Pro Glu Val Lys His Phe Phe Ala Leu His Pro 
465                 470                 475                 480 


Phe Thr Gly Glu Leu Ser Leu Leu Arg Ser Leu Asp Tyr Glu Ala Phe 
                485                 490                 495     


Pro Asp Gln Glu Ala Ser Ile Thr Phe Leu Val Glu Ala Phe Asp Ile 
            500                 505                 510         


Tyr Gly Thr Met Pro Pro Gly Ile Ala Thr Val Thr Val Ile Val Lys 
        515                 520                 525             


Asp Met Asn Asp Tyr Pro Pro Val Phe Ser Lys Arg Ile Tyr Lys Gly 
    530                 535                 540                 


Met Val Ala Pro Asp Ala Val Lys Gly Thr Pro Ile Thr Thr Val Tyr 
545                 550                 555                 560 


Ala Glu Asp Ala Asp Pro Pro Gly Leu Pro Ala Ser Arg Val Arg Tyr 
                565                 570                 575     


Arg Val Asp Asp Val Gln Phe Pro Tyr Pro Ala Ser Ile Phe Glu Val 
            580                 585                 590         


Glu Glu Asp Ser Gly Arg Val Ile Thr Arg Val Asn Leu Asn Glu Glu 
        595                 600                 605             


Pro Thr Thr Ile Phe Lys Leu Val Val Val Ala Phe Asp Asp Gly Glu 
    610                 615                 620                 


Pro Val Met Ser Ser Ser Ala Thr Val Lys Ile Leu Val Leu His Pro 
625                 630                 635                 640 


Gly Glu Ile Pro Arg Phe Thr Gln Glu Glu Tyr Arg Pro Pro Pro Val 
                645                 650                 655     


Ser Glu Leu Ala Thr Lys Gly Thr Met Val Gly Val Ile Ser Ala Ala 
            660                 665                 670         


Ala Ile Asn Gln Ser Ile Val Tyr Ser Ile Val Ser Gly Asn Glu Glu 
        675                 680                 685             


Asp Thr Phe Gly Ile Asn Asn Ile Thr Gly Val Ile Tyr Val Asn Gly 
    690                 695                 700                 


Pro Leu Asp Tyr Glu Thr Arg Thr Ser Tyr Val Leu Arg Val Gln Ala 
705                 710                 715                 720 


Asp Ser Leu Glu Val Val Leu Ala Asn Leu Arg Val Pro Ser Lys Ser 
                725                 730                 735     


Asn Thr Ala Lys Val Tyr Ile Glu Ile Gln Asp Glu Asn Asn His Pro 
            740                 745                 750         


Pro Val Phe Gln Lys Lys Phe Tyr Ile Gly Gly Val Ser Glu Asp Ala 
        755                 760                 765             


Arg Met Phe Thr Ser Val Leu Arg Val Lys Ala Thr Asp Lys Asp Thr 
    770                 775                 780                 


Gly Asn Tyr Ser Val Met Ala Tyr Arg Leu Ile Ile Pro Pro Ile Lys 
785                 790                 795                 800 


Glu Gly Lys Glu Gly Phe Val Val Glu Thr Tyr Thr Gly Leu Ile Lys 
                805                 810                 815     


Thr Ala Met Leu Phe His Asn Met Arg Arg Ser Tyr Phe Lys Phe Gln 
            820                 825                 830         


Val Ile Ala Thr Asp Asp Tyr Gly Lys Gly Leu Ser Gly Lys Ala Asp 
        835                 840                 845             


Val Leu Val Ser Val Val Asn Gln Leu Asp Met Gln Val Ile Val Ser 
    850                 855                 860                 


Asn Val Pro Pro Thr Leu Val Glu Lys Lys Ile Glu Asp Leu Thr Glu 
865                 870                 875                 880 


Ile Leu Asp Arg Tyr Val Gln Glu Gln Ile Pro Gly Ala Lys Val Val 
                885                 890                 895     


Val Glu Ser Ile Gly Ala Arg Arg His Gly Asp Ala Phe Ser Leu Glu 
            900                 905                 910         


Asp Tyr Thr Lys Cys Asp Leu Thr Val Tyr Ala Ile Asp Pro Gln Thr 
        915                 920                 925             


Asn Arg Ala Ile Asp Arg Asn Glu Leu Phe Lys Phe Leu Asp Gly Lys 
    930                 935                 940                 


Leu Leu Asp Ile Asn Lys Asp Phe Gln Pro Tyr Tyr Gly Glu Gly Gly 
945                 950                 955                 960 


Arg Ile Leu Glu Ile Arg Thr Pro Glu Ala Val Thr Ser Ile Lys Lys 
                965                 970                 975     


Arg Gly Glu Ser Leu Gly Tyr Thr Glu Gly Ala Leu Leu Ala Leu Ala 
            980                 985                 990         


Phe Ile Ile Ile Leu Cys Cys Ile  Pro Ala Ile Leu Val  Val Leu Val 
        995                 1000                 1005             


Ser Tyr  Arg Gln Phe Lys Val  Arg Gln Ala Glu Cys  Thr Lys Thr 
    1010                 1015                 1020             


Ala Arg  Ile Gln Ala Ala Leu  Pro Ala Ala Lys Pro  Ala Val Pro 
    1025                 1030                 1035             


Ala Pro  Ala Pro Val Ala Ala  Pro Pro Pro Pro Pro  Pro Pro Pro 
    1040                 1045                 1050             


Pro Gly  Ala His Leu Tyr Glu  Glu Leu Gly Asp Ser  Ser Met His 
    1055                 1060                 1065             


Lys Asn  Tyr Pro Trp Ser Leu  Glu Leu Ile Leu Ala  Arg Asn Met 
    1070                 1075                 1080             


Asp Lys  Ile Ile Thr Val Met  Ser Met Gly Met Lys  Cys Leu Asn 
    1085                 1090                 1095             


Met Gly  Val Ala Val Asp Cys  Tyr His Gln Leu Asp  Arg Arg Asn 
    1100                 1105                 1110             


Met Val  Arg Trp Leu Val Lys  Leu Arg Lys Asn Met  Arg Arg Lys 
    1115                 1120                 1125             


Arg Lys  Ser Gln Arg Lys Leu  Lys Asn Gln Arg Leu  Lys Leu Glu 
    1130                 1135                 1140             


Ser Leu  Val Arg Arg Lys Lys  
    1145                 1150 


<210>  10084
<211>  416
<212>  PRT
<213>  Homo Sapiens

<400>  10084

Met Gln Val Ile Val Ser Asn Val Pro Pro Thr Leu Val Glu Lys Lys 
1               5                   10                  15      


Ile Glu Asp Leu Thr Glu Ile Leu Asp Arg Tyr Val Gln Glu Gln Ile 
            20                  25                  30          


Pro Gly Ala Lys Val Val Val Glu Ser Ile Gly Ala Arg Arg His Gly 
        35                  40                  45              


Asp Ala Phe Ser Leu Glu Asp Tyr Thr Lys Cys Asp Leu Thr Val Tyr 
    50                  55                  60                  


Ala Ile Asp Pro Gln Thr Asn Arg Ala Ile Asp Arg Asn Glu Leu Phe 
65                  70                  75                  80  


Lys Phe Leu Asp Gly Lys Leu Leu Asp Ile Asn Lys Asp Phe Gln Pro 
                85                  90                  95      


Tyr Tyr Gly Glu Gly Gly Arg Ile Leu Glu Ile Arg Thr Pro Glu Ala 
            100                 105                 110         


Val Thr Ser Ile Lys Lys Arg Gly Glu Ser Leu Gly Tyr Thr Glu Gly 
        115                 120                 125             


Ala Leu Leu Ala Leu Ala Phe Ile Ile Ile Leu Cys Cys Ile Pro Ala 
    130                 135                 140                 


Ile Leu Val Val Leu Val Ser Tyr Arg Gln Arg Gly Tyr Gly Ser Glu 
145                 150                 155                 160 


Gln Gln Gln Leu Leu Arg Pro Ser Leu Leu Lys Pro Glu Glu Leu Ser 
                165                 170                 175     


Met Glu Ser Gly Ile Asp Pro Gly Gln Glu Tyr Gly Gln Asp Tyr Tyr 
            180                 185                 190         


Ser Tyr Glu His Gly Tyr Glu Met Pro Gln Tyr Gly Ser Arg Arg Arg 
        195                 200                 205             


Leu Leu Pro Pro Ala Gly Gln Glu Glu Tyr Gly Glu Val Val Gly Glu 
    210                 215                 220                 


Ala Glu Glu Glu Tyr Glu Glu Glu Glu Trp Ala Arg Lys Arg Met Ile 
225                 230                 235                 240 


Lys Leu Val Val Asp Arg Glu Tyr Glu Thr Ser Ser Thr Gly Glu Asp 
                245                 250                 255     


Ser Ala Pro Glu Cys Gln Arg Asn Arg Leu His His Pro Ser Ile His 
            260                 265                 270         


Ser Asn Ile Asn Gly Asn Ile Tyr Ile Ala Gln Asn Gly Ser Val Val 
        275                 280                 285             


Arg Thr Arg Arg Ala Cys Leu Thr Asp Asn Leu Lys Val Ala Ser Pro 
    290                 295                 300                 


Val Arg Leu Gly Gly Pro Phe Lys Lys Leu Asp Lys Leu Ala Val Thr 
305                 310                 315                 320 


His Glu Glu Asn Val Pro Leu Asn Thr Leu Ser Lys Gly Pro Phe Ser 
                325                 330                 335     


Thr Glu Lys Met Asn Ala Arg Pro Thr Leu Val Thr Phe Ala Pro Cys 
            340                 345                 350         


Pro Val Gly Thr Asp Asn Thr Ala Val Lys Pro Leu Arg Asn Arg Leu 
        355                 360                 365             


Lys Ser Thr Val Glu Gln Glu Ser Met Ile Asp Ser Lys Asn Ile Lys 
    370                 375                 380                 


Glu Ala Leu Glu Phe His Ser Asp His Thr Gln Ser Asp Asp Glu Glu 
385                 390                 395                 400 


Leu Trp Met Gly Pro Trp Asn Asn Leu His Ile Pro Met Thr Lys Leu 
                405                 410                 415     


<210>  10085
<211>  1360
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  10085

Xaa His Ile Glu Ile Leu Asp Glu Asn Asn Gln Ser Pro Tyr Phe Thr 
1               5                   10                  15      


Met Pro Ser Tyr Gln Gly Tyr Ile Leu Glu Ser Ala Pro Val Gly Ala 
            20                  25                  30          


Thr Ile Ser Asp Ser Leu Asn Leu Thr Ser Pro Leu Arg Ile Val Ala 
        35                  40                  45              


Leu Asp Lys Asp Ile Glu Asp Thr Lys Asp Pro Glu Leu His Leu Phe 
    50                  55                  60                  


Leu Asn Asp Tyr Thr Ser Val Phe Thr Val Thr Gln Thr Gly Ile Thr 
65                  70                  75                  80  


Arg Tyr Leu Thr Leu Leu Gln Pro Val Asp Arg Glu Glu Gln Gln Thr 
                85                  90                  95      


Tyr Thr Phe Ser Ile Thr Ala Phe Asp Gly Val Gln Glu Ser Glu Pro 
            100                 105                 110         


Val Ile Val Asn Ile Gln Val Met Asp Ala Asn Asp Asn Thr Pro Thr 
        115                 120                 125             


Phe Pro Glu Ile Ser Tyr Asp Val Tyr Val Tyr Thr Asp Met Arg Pro 
    130                 135                 140                 


Gly Asp Ser Val Ile Gln Leu Thr Ala Val Asp Ala Asp Glu Gly Ser 
145                 150                 155                 160 


Asn Gly Glu Ile Thr Tyr Glu Ile Leu Val Gly Ala Gln Gly Asp Phe 
                165                 170                 175     


Ile Ile Asn Lys Thr Thr Gly Leu Ile Thr Ile Ala Pro Gly Val Glu 
            180                 185                 190         


Met Ile Val Gly Arg Thr Tyr Ala Leu Thr Val Gln Ala Ala Asp Asn 
        195                 200                 205             


Ala Pro Pro Ala Glu Arg Arg Asn Ser Ile Cys Thr Val Tyr Ile Glu 
    210                 215                 220                 


Val Leu Pro Pro Asn Asn Gln Ser Pro Pro Arg Phe Pro Gln Leu Met 
225                 230                 235                 240 


Tyr Ser Leu Glu Ile Ser Glu Ala Met Arg Val Gly Ala Val Leu Leu 
                245                 250                 255     


Asn Leu Gln Ala Thr Asp Arg Glu Gly Asp Ser Ile Thr Tyr Ala Ile 
            260                 265                 270         


Glu Asn Gly Asp Pro Gln Arg Val Phe Asn Leu Ser Glu Thr Thr Gly 
        275                 280                 285             


Ile Leu Thr Leu Gly Lys Ala Leu Asp Arg Glu Ser Thr Asp Arg Tyr 
    290                 295                 300                 


Ile Leu Ile Ile Thr Ala Ser Asp Gly Arg Pro Asp Gly Thr Ser Thr 
305                 310                 315                 320 


Ala Thr Val Asn Ile Val Val Thr Asp Val Asn Asp Asn Ala Pro Val 
                325                 330                 335     


Phe Asp Pro Tyr Leu Pro Arg Asn Leu Ser Val Val Glu Glu Glu Ala 
            340                 345                 350         


Asn Ala Phe Val Gly Gln Val Lys Ala Thr Asp Pro Asp Ala Gly Ile 
        355                 360                 365             


Asn Gly Gln Val His Tyr Ser Leu Gly Asn Phe Asn Asn Leu Phe Arg 
    370                 375                 380                 


Ile Thr Ser Asn Gly Ser Ile Tyr Thr Ala Val Lys Leu Asn Arg Glu 
385                 390                 395                 400 


Val Arg Asp Tyr Tyr Glu Leu Val Val Val Ala Thr Asp Gly Ala Val 
                405                 410                 415     


His Pro Arg His Ser Thr Leu Thr Leu Ala Ile Lys Val Leu Asp Ile 
            420                 425                 430         


Asp Asp Asn Ser Pro Val Phe Thr Asn Ser Thr Tyr Thr Val Leu Val 
        435                 440                 445             


Glu Glu Asn Leu Pro Ala Gly Thr Thr Ile Leu Gln Ile Glu Ala Lys 
    450                 455                 460                 


Asp Val Asp Leu Gly Ala Asn Val Ser Tyr Arg Ile Arg Ser Pro Glu 
465                 470                 475                 480 


Val Lys His Phe Phe Ala Leu His Pro Phe Thr Gly Glu Leu Ser Leu 
                485                 490                 495     


Leu Arg Ser Leu Asp Tyr Glu Ala Phe Pro Asp Gln Glu Ala Ser Ile 
            500                 505                 510         


Thr Phe Leu Val Glu Ala Phe Asp Ile Tyr Gly Thr Met Pro Pro Gly 
        515                 520                 525             


Ile Ala Thr Val Thr Val Ile Val Lys Asp Met Asn Asp Tyr Pro Pro 
    530                 535                 540                 


Val Phe Ser Lys Arg Ile Tyr Lys Gly Met Val Ala Pro Asp Ala Val 
545                 550                 555                 560 


Lys Gly Thr Pro Ile Thr Thr Val Tyr Ala Glu Asp Ala Asp Pro Pro 
                565                 570                 575     


Gly Leu Pro Ala Ser Arg Val Arg Tyr Arg Val Asp Asp Val Gln Phe 
            580                 585                 590         


Pro Tyr Pro Ala Ser Ile Phe Glu Val Glu Glu Asp Ser Gly Arg Val 
        595                 600                 605             


Ile Thr Arg Val Asn Leu Asn Glu Glu Pro Thr Thr Ile Phe Lys Leu 
    610                 615                 620                 


Val Val Val Ala Phe Asp Asp Gly Glu Pro Val Met Ser Ser Ser Ala 
625                 630                 635                 640 


Thr Val Lys Ile Leu Val Leu His Pro Gly Glu Ile Pro Arg Phe Thr 
                645                 650                 655     


Gln Glu Glu Tyr Arg Pro Pro Pro Val Ser Glu Leu Ala Thr Lys Gly 
            660                 665                 670         


Thr Met Val Gly Val Ile Ser Ala Ala Ala Ile Asn Gln Ser Ile Val 
        675                 680                 685             


Tyr Ser Ile Val Ser Gly Asn Glu Glu Asp Thr Phe Gly Ile Asn Asn 
    690                 695                 700                 


Ile Thr Gly Val Ile Tyr Val Asn Gly Pro Leu Asp Tyr Glu Thr Arg 
705                 710                 715                 720 


Thr Ser Tyr Val Leu Arg Val Gln Ala Asp Ser Leu Glu Val Val Leu 
                725                 730                 735     


Ala Asn Leu Arg Val Pro Ser Lys Ser Asn Thr Ala Lys Val Tyr Ile 
            740                 745                 750         


Glu Ile Gln Asp Glu Asn Asn His Pro Pro Val Phe Gln Lys Lys Phe 
        755                 760                 765             


Tyr Ile Gly Gly Val Ser Glu Asp Ala Arg Met Phe Thr Ser Val Leu 
    770                 775                 780                 


Arg Val Lys Ala Thr Asp Lys Asp Thr Gly Asn Tyr Ser Val Met Ala 
785                 790                 795                 800 


Tyr Arg Leu Ile Ile Pro Pro Ile Lys Glu Gly Lys Glu Gly Phe Val 
                805                 810                 815     


Val Glu Thr Tyr Thr Gly Leu Ile Lys Thr Ala Met Leu Phe His Asn 
            820                 825                 830         


Met Arg Arg Ser Tyr Phe Lys Phe Gln Val Ile Ala Thr Asp Asp Tyr 
        835                 840                 845             


Gly Lys Gly Leu Ser Gly Lys Ala Asp Val Leu Val Ser Val Val Asn 
    850                 855                 860                 


Gln Leu Asp Met Gln Val Ile Val Ser Asn Val Pro Pro Thr Leu Val 
865                 870                 875                 880 


Glu Lys Lys Ile Glu Asp Leu Thr Glu Ile Leu Asp Arg Tyr Val Gln 
                885                 890                 895     


Glu Gln Ile Pro Gly Ala Lys Val Val Val Glu Ser Ile Gly Ala Arg 
            900                 905                 910         


Arg His Gly Asp Ala Phe Ser Leu Glu Asp Tyr Thr Lys Cys Asp Leu 
        915                 920                 925             


Thr Val Tyr Ala Ile Asp Pro Gln Thr Asn Arg Ala Ile Asp Arg Asn 
    930                 935                 940                 


Glu Leu Phe Lys Phe Leu Asp Gly Lys Leu Leu Asp Ile Asn Lys Asp 
945                 950                 955                 960 


Phe Gln Pro Tyr Tyr Gly Glu Gly Gly Arg Ile Leu Glu Ile Arg Thr 
                965                 970                 975     


Pro Glu Ala Val Thr Ser Ile Lys Lys Arg Gly Glu Ser Leu Gly Tyr 
            980                 985                 990         


Thr Glu Gly Ala Leu Leu Ala Leu  Ala Phe Ile Ile Ile  Leu Cys Cys 
        995                 1000                 1005             


Ile Pro  Ala Ile Leu Val Val  Leu Val Ser Tyr Arg  Gln Phe Lys 
    1010                 1015                 1020             


Val Arg  Gln Ala Glu Cys Thr  Lys Thr Ala Arg Ile  Gln Ala Ala 
    1025                 1030                 1035             


Leu Pro  Ala Ala Lys Pro Ala  Val Pro Ala Pro Ala  Pro Val Ala 
    1040                 1045                 1050             


Ala Pro  Pro Pro Pro Pro Pro  Pro Pro Pro Gly Ala  His Leu Tyr 
    1055                 1060                 1065             


Glu Glu  Leu Gly Asp Ser Ser  Ile Trp Ser Phe Cys  Trp Gln Leu 
    1070                 1075                 1080             


Val Ile  Cys Met Arg Thr Cys  Ala Ile Trp Arg Thr  Leu Thr Arg 
    1085                 1090                 1095             


Arg Gly  Tyr Gly Ser Glu Gln  Gln Gln Leu Leu Arg  Pro Ser Leu 
    1100                 1105                 1110             


Leu Lys  Pro Glu Glu Leu Ser  Met Glu Ser Gly Ile  Asp Pro Gly 
    1115                 1120                 1125             


Gln Glu  Tyr Gly Gln Asp Tyr  Tyr Ser Tyr Glu His  Gly Tyr Glu 
    1130                 1135                 1140             


Met Pro  Gln Tyr Gly Ser Arg  Arg Arg Leu Leu Pro  Pro Ala Gly 
    1145                 1150                 1155             


Gln Glu  Glu Tyr Gly Glu Val  Val Gly Glu Ala Glu  Glu Glu Tyr 
    1160                 1165                 1170             


Glu Glu  Glu Glu Trp Ala Arg  Lys Arg Met Ile Lys  Leu Val Val 
    1175                 1180                 1185             


Asp Arg  Glu Tyr Glu Thr Ser  Ser Thr Gly Glu Asp  Ser Ala Pro 
    1190                 1195                 1200             


Glu Cys  Gln Arg Asn Arg Leu  His His Pro Ser Ile  His Ser Asn 
    1205                 1210                 1215             


Ile Asn  Gly Asn Ile Tyr Ile  Ala Gln Asn Gly Ser  Val Val Arg 
    1220                 1225                 1230             


Thr Arg  Arg Ala Cys Leu Thr  Asp Asn Leu Lys Val  Ala Ser Pro 
    1235                 1240                 1245             


Val Arg  Leu Gly Gly Pro Phe  Lys Lys Leu Asp Lys  Leu Ala Val 
    1250                 1255                 1260             


Thr His  Glu Glu Asn Val Pro  Leu Asn Thr Leu Ser  Lys Gly Pro 
    1265                 1270                 1275             


Phe Ser  Thr Glu Lys Met Asn  Ala Arg Pro Thr Leu  Val Thr Phe 
    1280                 1285                 1290             


Ala Pro  Cys Pro Val Gly Thr  Asp Asn Thr Ala Val  Lys Pro Leu 
    1295                 1300                 1305             


Arg Asn  Arg Leu Lys Ser Thr  Val Glu Gln Glu Ser  Met Ile Asp 
    1310                 1315                 1320             


Ser Lys  Asn Ile Lys Glu Ala  Leu Glu Phe His Ser  Asp His Thr 
    1325                 1330                 1335             


Gln Ser  Asp Asp Glu Glu Leu  Trp Met Gly Pro Trp  Asn Asn Leu 
    1340                 1345                 1350             


His Ile  Pro Met Thr Lys Leu  
    1355                 1360 


<210>  10086
<211>  37
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  10086

Xaa Met Lys Cys Leu Asn Met Gly Val Ala Val Asp Cys Tyr His Gln 
1               5                   10                  15      


Leu Asp Arg Arg Asn Met Val Arg Trp Leu Val Lys Leu Arg Lys Asn 
            20                  25                  30          


Met Arg Arg Lys Arg 
        35          


<210>  10087
<211>  807
<212>  PRT
<213>  Homo Sapiens

<400>  10087

Met Val Phe Ser Arg Arg Gly Gly Leu Gly Ala Arg Asp Leu Leu Leu 
1               5                   10                  15      


Trp Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Ile Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Val 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Thr His Arg Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gln Trp Ser Ala Glu Cys Ser Ile His Leu Glu Leu Ile Ala Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Glu Val Lys Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Arg Gly Arg Glu Gln Ile Ile Phe Ile Pro Glu 
    130                 135                 140                 


Ser Arg Leu Leu Asn Ser Arg Phe Pro Ile Glu Gly Ala Ala Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Ala Asn Ala Leu Leu Thr Tyr Thr Leu Ser Pro Ser Asp 
                165                 170                 175     


Tyr Phe Ser Leu Asp Val Glu Ala Ser Asp Glu Leu Ser Lys Ser Leu 
            180                 185                 190         


Trp Leu Glu Leu Arg Lys Tyr Leu Asp Arg Glu Glu Thr Pro Glu Leu 
        195                 200                 205             


His Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Gln Gly 
    210                 215                 220                 


Thr Val Glu Leu Leu Ile Thr Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Leu Phe Asp Gln Ala Val Tyr Arg Val His Leu Leu Glu Thr Thr Ala 
                245                 250                 255     


Asn Gly Thr Leu Val Thr Thr Leu Asn Ala Ser Asp Ala Asp Glu Gly 
            260                 265                 270         


Val Asn Gly Glu Val Val Phe Ser Phe Asp Ser Gly Ile Ser Arg Asp 
        275                 280                 285             


Ile Gln Glu Lys Phe Lys Val Asp Ser Ser Ser Gly Glu Ile Arg Leu 
    290                 295                 300                 


Ile Asp Lys Leu Asp Tyr Glu Glu Thr Lys Ser Tyr Glu Ile Gln Val 
305                 310                 315                 320 


Lys Ala Val Asp Lys Gly Ser Pro Pro Met Ser Asn His Cys Lys Val 
                325                 330                 335     


Leu Val Lys Val Leu Asp Val Asn Asp Asn Ala Pro Glu Leu Ala Val 
            340                 345                 350         


Thr Ser Leu Tyr Leu Pro Ile Arg Glu Asp Ala Pro Leu Ser Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Thr Val Ser Asp Arg Asp Ser Gly Ala Asn Gly Gln 
    370                 375                 380                 


Val Thr Cys Ser Leu Met Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Leu Ser Val Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Arg Val Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Asn Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Ala Pro Arg Val Gly Gly Thr Ile Gly Ala 
                565                 570                 575     


Val Ser Glu Leu Val Pro Arg Leu Val Gly Ala Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Ala Ala Gly Gly Ala Arg Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Val Leu Asp Glu Ala 
625                 630                 635                 640 


Asp Leu Ser Arg Tyr Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ala Ser Ser Arg Ala Ser Val Gly Val Ala Gly 
        675                 680                 685             


Pro Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Val Pro Pro Thr Glu Gly Ala Tyr Val Pro Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Leu Gly Ser Trp Ser Asn Ser Gln 
            740                 745                 750         


Gln Arg Arg Gln Arg Val Cys Ser Ser Glu Gly Pro Pro Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Gly Leu Ser Pro Ser Leu Asn Thr Ser Glu 
    770                 775                 780                 


Arg Asn Glu Gln Pro Glu Ala Asn Leu Asp Leu Ser Gly Asn Val Ser 
785                 790                 795                 800 


Pro Thr Phe Glu Phe Trp Leu 
                805         


<210>  10088
<211>  686
<212>  PRT
<213>  Homo Sapiens

<400>  10088

Met Val Phe Ser Arg Arg Gly Gly Leu Gly Ala Arg Asp Leu Leu Leu 
1               5                   10                  15      


Trp Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Ile Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Val 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Thr His Arg Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gln Trp Ser Ala Glu Cys Ser Ile His Leu Glu Leu Ile Ala Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Glu Val Lys Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Arg Gly Arg Glu Gln Ile Ile Phe Ile Pro Glu 
    130                 135                 140                 


Ser Arg Leu Leu Asn Ser Arg Phe Pro Ile Glu Gly Ala Ala Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Ala Asn Ala Leu Leu Thr Tyr Thr Leu Ser Pro Ser Asp 
                165                 170                 175     


Tyr Phe Ser Leu Asp Val Glu Ala Ser Asp Glu Leu Ser Lys Ser Leu 
            180                 185                 190         


Trp Leu Glu Leu Arg Lys Tyr Leu Asp Arg Glu Glu Thr Pro Glu Leu 
        195                 200                 205             


His Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Gln Gly 
    210                 215                 220                 


Thr Val Glu Leu Leu Ile Thr Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Leu Phe Asp Gln Ala Val Tyr Arg Val His Leu Leu Glu Thr Thr Ala 
                245                 250                 255     


Asn Gly Thr Leu Val Thr Thr Leu Asn Ala Ser Asp Ala Asp Glu Gly 
            260                 265                 270         


Val Asn Gly Glu Val Val Phe Ser Phe Asp Ser Gly Ile Ser Arg Asp 
        275                 280                 285             


Ile Gln Glu Lys Phe Lys Val Asp Ser Ser Ser Gly Glu Ile Arg Leu 
    290                 295                 300                 


Ile Asp Lys Leu Asp Tyr Glu Glu Thr Lys Ser Tyr Glu Ile Gln Val 
305                 310                 315                 320 


Lys Ala Val Asp Lys Gly Ser Pro Pro Met Ser Asn His Cys Lys Val 
                325                 330                 335     


Leu Val Lys Val Leu Asp Val Asn Asp Asn Ala Pro Glu Leu Ala Val 
            340                 345                 350         


Thr Ser Leu Tyr Leu Pro Ile Arg Glu Asp Ala Pro Leu Ser Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Thr Val Ser Asp Arg Asp Ser Gly Ala Asn Gly Gln 
    370                 375                 380                 


Val Thr Cys Ser Leu Met Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Leu Ser Val Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Arg Val Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Asn Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Pro Arg Gln Pro Asn Pro Asp Trp Arg Tyr 
    530                 535                 540                 


Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser Val His Leu Glu Glu 
545                 550                 555                 560 


Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro Asp Gln Gln Trp Pro 
                565                 570                 575     


Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala Gly Glu Val Ser Pro 
            580                 585                 590         


Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp Thr Phe Lys Tyr Gly 
        595                 600                 605             


Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu Leu Pro Asp Lys Phe 
    610                 615                 620                 


Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile Arg Gln Glu Pro Thr 
625                 630                 635                 640 


Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr Phe Gly Lys Lys Glu 
                645                 650                 655     


Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly Asn Lys Thr Gln Glu 
            660                 665                 670         


Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp Asn Ser Asp Gln 
        675                 680                 685     


<210>  10089
<211>  950
<212>  PRT
<213>  Homo Sapiens

<400>  10089

Met Val Phe Ser Arg Arg Gly Gly Leu Gly Ala Arg Asp Leu Leu Leu 
1               5                   10                  15      


Trp Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Ile Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Val 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Thr His Arg Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gln Trp Ser Ala Glu Cys Ser Ile His Leu Glu Leu Ile Ala Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Glu Val Lys Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Arg Gly Arg Glu Gln Ile Ile Phe Ile Pro Glu 
    130                 135                 140                 


Ser Arg Leu Leu Asn Ser Arg Phe Pro Ile Glu Gly Ala Ala Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Ala Asn Ala Leu Leu Thr Tyr Thr Leu Ser Pro Ser Asp 
                165                 170                 175     


Tyr Phe Ser Leu Asp Val Glu Ala Ser Asp Glu Leu Ser Lys Ser Leu 
            180                 185                 190         


Trp Leu Glu Leu Arg Lys Tyr Leu Asp Arg Glu Glu Thr Pro Glu Leu 
        195                 200                 205             


His Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Gln Gly 
    210                 215                 220                 


Thr Val Glu Leu Leu Ile Thr Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Leu Phe Asp Gln Ala Val Tyr Arg Val His Leu Leu Glu Thr Thr Ala 
                245                 250                 255     


Asn Gly Thr Leu Val Thr Thr Leu Asn Ala Ser Asp Ala Asp Glu Gly 
            260                 265                 270         


Val Asn Gly Glu Val Val Phe Ser Phe Asp Ser Gly Ile Ser Arg Asp 
        275                 280                 285             


Ile Gln Glu Lys Phe Lys Val Asp Ser Ser Ser Gly Glu Ile Arg Leu 
    290                 295                 300                 


Ile Asp Lys Leu Asp Tyr Glu Glu Thr Lys Ser Tyr Glu Ile Gln Val 
305                 310                 315                 320 


Lys Ala Val Asp Lys Gly Ser Pro Pro Met Ser Asn His Cys Lys Val 
                325                 330                 335     


Leu Val Lys Val Leu Asp Val Asn Asp Asn Ala Pro Glu Leu Ala Val 
            340                 345                 350         


Thr Ser Leu Tyr Leu Pro Ile Arg Glu Asp Ala Pro Leu Ser Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Thr Val Ser Asp Arg Asp Ser Gly Ala Asn Gly Gln 
    370                 375                 380                 


Val Thr Cys Ser Leu Met Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Leu Ser Val Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Arg Val Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Asn Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Ala Pro Arg Val Gly Gly Thr Ile Gly Ala 
                565                 570                 575     


Val Ser Glu Leu Val Pro Arg Leu Val Gly Ala Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Ala Ala Gly Gly Ala Arg Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Val Leu Asp Glu Ala 
625                 630                 635                 640 


Asp Leu Ser Arg Tyr Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ala Ser Ser Arg Ala Ser Val Gly Val Ala Gly 
        675                 680                 685             


Pro Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Val Pro Pro Thr Glu Gly Ala Tyr Val Pro Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Leu Gly Ser Trp Ser Asn Ser Gln 
            740                 745                 750         


Gln Arg Arg Gln Arg Val Cys Ser Ser Glu Gly Pro Pro Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Gly Leu Ser Pro Ser Leu Asn Thr Ser Glu 
    770                 775                 780                 


Arg Asn Glu Gln Pro Glu Ala Asn Leu Asp Leu Ser Gly Asn Pro Arg 
785                 790                 795                 800 


Gln Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met 
                805                 810                 815     


His Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro 
            820                 825                 830         


Gly Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu 
        835                 840                 845             


Pro Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser 
    850                 855                 860                 


Asn Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly 
865                 870                 875                 880 


Pro Gly Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile 
                885                 890                 895     


Ile Ser Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp 
            900                 905                 910         


Phe Ile Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys 
        915                 920                 925             


Lys Lys Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr 
    930                 935                 940                 


Thr Asp Asn Ser Asp Gln 
945                 950 


<210>  10090
<211>  948
<212>  PRT
<213>  Homo Sapiens

<400>  10090

Met Val Ser Arg Cys Ser Cys Leu Gly Val Gln Cys Leu Leu Leu Ser 
1               5                   10                  15      


Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu His Tyr 
            20                  25                  30          


Ser Val Tyr Glu Glu Ala Arg His Gly Thr Phe Val Gly Arg Ile Ala 
        35                  40                  45              


Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Gln Arg Leu Phe Arg 
    50                  55                  60                  


Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln Asn 
65                  70                  75                  80  


Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys Gly 
                85                  90                  95      


Arg Ser Val Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg Pro 
            100                 105                 110         


Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Ile Asn Asp Asn 
        115                 120                 125             


Pro Pro Arg Phe Ser Val Thr Glu Gln Lys Leu Ser Ile Pro Glu Ser 
    130                 135                 140                 


Arg Leu Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala Asp 
145                 150                 155                 160 


Val Gly Glu Asn Ala Leu Leu Thr Tyr Lys Leu Ser Pro Asn Glu Tyr 
                165                 170                 175     


Phe Val Leu Asp Ile Ile Asn Lys Lys Asp Lys Asp Lys Phe Pro Val 
            180                 185                 190         


Leu Val Leu Arg Lys Leu Leu Asp Arg Glu Glu Asn Pro Gln Leu Lys 
        195                 200                 205             


Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Phe Thr Gly Ser 
    210                 215                 220                 


Val Ser Leu Leu Ile Leu Val Leu Asp Ala Asn Asp Asn Ala Pro Ile 
225                 230                 235                 240 


Phe Asp Arg Pro Val Tyr Glu Val Lys Met Tyr Glu Asn Gln Val Asn 
                245                 250                 255     


Gln Thr Leu Val Ile Arg Leu Asn Ala Ser Asp Ser Asp Glu Gly Ile 
            260                 265                 270         


Asn Lys Glu Met Met Tyr Ser Phe Ser Ser Leu Val Pro Pro Thr Ile 
        275                 280                 285             


Arg Arg Lys Phe Trp Ile Asn Glu Arg Thr Gly Glu Ile Lys Val Asn 
    290                 295                 300                 


Asp Ala Ile Asp Phe Glu Asp Ser Asn Thr Tyr Glu Ile His Val Asp 
305                 310                 315                 320 


Val Thr Asp Lys Gly Asn Pro Pro Met Val Gly His Cys Thr Val Leu 
                325                 330                 335     


Val Glu Leu Leu Asp Glu Asn Asp Asn Ser Pro Glu Val Ile Val Thr 
            340                 345                 350         


Ser Leu Ser Leu Pro Val Lys Glu Asp Ala Gln Val Gly Thr Val Ile 
        355                 360                 365             


Ala Leu Ile Ser Val Ser Asp His Asp Ser Gly Ala Asn Gly Gln Val 
    370                 375                 380                 


Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr Tyr 
385                 390                 395                 400 


Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu Arg 
                405                 410                 415     


Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser Pro 
            420                 425                 430         


Pro Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Ala Phe Ala Gln Ser Glu Tyr Thr Val Phe Val Lys 
    450                 455                 460                 


Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Trp Asp 
465                 470                 475                 480 


Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu Arg 
                485                 490                 495     


Arg Leu Gly Glu Arg Ser Leu Ser Ser Tyr Val Ser Val His Ala Glu 
            500                 505                 510         


Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu Glu 
        515                 520                 525             


Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Gly Gly Val Pro Pro Leu 
    530                 535                 540                 


Gly Ser Asn Leu Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp Asn 
545                 550                 555                 560 


Ala Pro Ala Leu Leu Ala Ser Pro Ala Gly Ser Ala Gly Gly Ala Val 
                565                 570                 575     


Ser Glu Leu Val Leu Arg Ser Val Val Ala Gly His Val Val Ala Lys 
            580                 585                 590         


Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser Tyr 
        595                 600                 605             


Glu Leu Gln Ser Ala Ala Val Gly Ala Arg Ile Pro Phe Arg Val Gly 
    610                 615                 620                 


Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Thr Asp 
625                 630                 635                 640 


Ser Pro Arg Gln Arg Leu Leu Val Leu Val Lys Asp His Gly Glu Pro 
                645                 650                 655     


Ser Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Gly Ser 
            660                 665                 670         


Gln Ala Pro Lys Ala Ser Ser Arg Ala Ser Val Gly Val Ala Pro Glu 
        675                 680                 685             


Val Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile Cys Ala 
    690                 695                 700                 


Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala Leu Arg 
705                 710                 715                 720 


Cys Ser Ala Ala Pro Thr Glu Gly Ala Cys Gly Pro Val Lys Pro Thr 
                725                 730                 735     


Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln Gln Arg 
            740                 745                 750         


Arg Gln Arg Val Cys Ser Gly Glu Gly Leu Pro Lys Ala Asp Leu Met 
        755                 760                 765             


Ala Phe Ser Pro Ser Leu Pro Pro Cys Pro Met Val Asp Val Asp Gly 
    770                 775                 780                 


Glu Asp Gln Ser Ile Gly Gly Asp His Ser Arg Lys Pro Arg Gln Pro 
785                 790                 795                 800 


Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser 
                805                 810                 815     


Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly 
            820                 825                 830         


Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu 
        835                 840                 845             


Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser 
    850                 855                 860                 


Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly 
865                 870                 875                 880 


Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser 
                885                 890                 895     


Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile 
            900                 905                 910         


Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys 
        915                 920                 925             


Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp 
    930                 935                 940                 


Asn Ser Asp Gln 
945             


<210>  10091
<211>  844
<212>  PRT
<213>  Homo Sapiens

<400>  10091

Met Val Ser Arg Cys Ser Cys Leu Gly Val Gln Cys Leu Leu Leu Ser 
1               5                   10                  15      


Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu His Tyr 
            20                  25                  30          


Ser Val Tyr Glu Glu Ala Arg His Gly Thr Phe Val Gly Arg Ile Ala 
        35                  40                  45              


Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Gln Arg Leu Phe Arg 
    50                  55                  60                  


Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln Asn 
65                  70                  75                  80  


Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys Gly 
                85                  90                  95      


Arg Ser Val Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg Pro 
            100                 105                 110         


Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Ile Asn Asp Asn 
        115                 120                 125             


Pro Pro Arg Phe Ser Val Thr Glu Gln Lys Leu Ser Ile Pro Glu Ser 
    130                 135                 140                 


Arg Leu Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala Asp 
145                 150                 155                 160 


Val Gly Glu Asn Ala Leu Leu Thr Tyr Lys Leu Ser Pro Asn Glu Tyr 
                165                 170                 175     


Phe Val Leu Asp Ile Ile Asn Lys Lys Asp Lys Asp Lys Phe Pro Val 
            180                 185                 190         


Leu Val Leu Arg Lys Leu Leu Asp Arg Glu Glu Asn Pro Gln Leu Lys 
        195                 200                 205             


Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Phe Thr Gly Ser 
    210                 215                 220                 


Val Ser Leu Leu Ile Leu Val Leu Asp Ala Asn Asp Asn Ala Pro Ile 
225                 230                 235                 240 


Phe Asp Arg Pro Val Tyr Glu Val Lys Met Tyr Glu Asn Gln Val Asn 
                245                 250                 255     


Gln Thr Leu Val Ile Arg Leu Asn Ala Ser Asp Ser Asp Glu Gly Ile 
            260                 265                 270         


Asn Lys Glu Met Met Tyr Ser Phe Ser Ser Leu Val Pro Pro Thr Ile 
        275                 280                 285             


Arg Arg Lys Phe Trp Ile Asn Glu Arg Thr Gly Glu Ile Lys Val Asn 
    290                 295                 300                 


Asp Ala Ile Asp Phe Glu Asp Ser Asn Thr Tyr Glu Ile His Val Asp 
305                 310                 315                 320 


Val Thr Asp Lys Gly Asn Pro Pro Met Val Gly His Cys Thr Val Leu 
                325                 330                 335     


Val Glu Leu Leu Asp Glu Asn Asp Asn Ser Pro Glu Val Ile Val Thr 
            340                 345                 350         


Ser Leu Ser Leu Pro Val Lys Glu Asp Ala Gln Val Gly Thr Val Ile 
        355                 360                 365             


Ala Leu Ile Ser Val Ser Asp His Asp Ser Gly Ala Asn Gly Gln Val 
    370                 375                 380                 


Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr Tyr 
385                 390                 395                 400 


Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu Arg 
                405                 410                 415     


Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser Pro 
            420                 425                 430         


Pro Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Ala Phe Ala Gln Ser Glu Tyr Thr Val Phe Val Lys 
    450                 455                 460                 


Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Trp Asp 
465                 470                 475                 480 


Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu Arg 
                485                 490                 495     


Arg Leu Gly Glu Arg Ser Leu Ser Ser Tyr Val Ser Val His Ala Glu 
            500                 505                 510         


Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu Glu 
        515                 520                 525             


Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Gly Gly Val Pro Pro Leu 
    530                 535                 540                 


Gly Ser Asn Leu Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp Asn 
545                 550                 555                 560 


Ala Pro Ala Leu Leu Ala Ser Pro Ala Gly Ser Ala Gly Gly Ala Val 
                565                 570                 575     


Ser Glu Leu Val Leu Arg Ser Val Val Ala Gly His Val Val Ala Lys 
            580                 585                 590         


Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser Tyr 
        595                 600                 605             


Glu Leu Gln Ser Ala Ala Val Gly Ala Arg Ile Pro Phe Arg Val Gly 
    610                 615                 620                 


Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Thr Asp 
625                 630                 635                 640 


Ser Pro Arg Gln Arg Leu Leu Val Leu Val Lys Asp His Gly Glu Pro 
                645                 650                 655     


Ser Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Gly Ser 
            660                 665                 670         


Gln Ala Pro Lys Ala Ser Ser Arg Ala Ser Val Gly Val Ala Pro Glu 
        675                 680                 685             


Val Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile Cys Ala 
    690                 695                 700                 


Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala Leu Arg 
705                 710                 715                 720 


Cys Ser Ala Ala Pro Thr Glu Gly Ala Cys Gly Pro Val Lys Pro Thr 
                725                 730                 735     


Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln Gln Arg 
            740                 745                 750         


Arg Gln Arg Val Cys Ser Gly Glu Gly Leu Pro Lys Ala Asp Leu Met 
        755                 760                 765             


Ala Phe Ser Pro Ser Leu Pro Pro Cys Pro Met Val Asp Val Asp Gly 
    770                 775                 780                 


Glu Asp Gln Ser Ile Gly Gly Asp His Ser Arg Lys Val Gly Tyr Tyr 
785                 790                 795                 800 


Val Phe Ile Phe Leu Leu Cys Phe Met Asn Asn Ile Phe Ser Tyr Arg 
                805                 810                 815     


Ile Phe Ser Asn Met Tyr Gln Asn Ile Ser Phe Leu Ser Thr Phe His 
            820                 825                 830         


Leu Cys Leu Asn Ile Ser Ser Asp Thr Phe Val Ile 
        835                 840                 


<210>  10092
<211>  685
<212>  PRT
<213>  Homo Sapiens

<400>  10092

Met Val Ser Arg Cys Ser Cys Leu Gly Val Gln Cys Leu Leu Leu Ser 
1               5                   10                  15      


Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu His Tyr 
            20                  25                  30          


Ser Val Tyr Glu Glu Ala Arg His Gly Thr Phe Val Gly Arg Ile Ala 
        35                  40                  45              


Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Gln Arg Leu Phe Arg 
    50                  55                  60                  


Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln Asn 
65                  70                  75                  80  


Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys Gly 
                85                  90                  95      


Arg Ser Val Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg Pro 
            100                 105                 110         


Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Ile Asn Asp Asn 
        115                 120                 125             


Pro Pro Arg Phe Ser Val Thr Glu Gln Lys Leu Ser Ile Pro Glu Ser 
    130                 135                 140                 


Arg Leu Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala Asp 
145                 150                 155                 160 


Val Gly Glu Asn Ala Leu Leu Thr Tyr Lys Leu Ser Pro Asn Glu Tyr 
                165                 170                 175     


Phe Val Leu Asp Ile Ile Asn Lys Lys Asp Lys Asp Lys Phe Pro Val 
            180                 185                 190         


Leu Val Leu Arg Lys Leu Leu Asp Arg Glu Glu Asn Pro Gln Leu Lys 
        195                 200                 205             


Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Phe Thr Gly Ser 
    210                 215                 220                 


Val Ser Leu Leu Ile Leu Val Leu Asp Ala Asn Asp Asn Ala Pro Ile 
225                 230                 235                 240 


Phe Asp Arg Pro Val Tyr Glu Val Lys Met Tyr Glu Asn Gln Val Asn 
                245                 250                 255     


Gln Thr Leu Val Ile Arg Leu Asn Ala Ser Asp Ser Asp Glu Gly Ile 
            260                 265                 270         


Asn Lys Glu Met Met Tyr Ser Phe Ser Ser Leu Val Pro Pro Thr Ile 
        275                 280                 285             


Arg Arg Lys Phe Trp Ile Asn Glu Arg Thr Gly Glu Ile Lys Val Asn 
    290                 295                 300                 


Asp Ala Ile Asp Phe Glu Asp Ser Asn Thr Tyr Glu Ile His Val Asp 
305                 310                 315                 320 


Val Thr Asp Lys Gly Asn Pro Pro Met Val Gly His Cys Thr Val Leu 
                325                 330                 335     


Val Glu Leu Leu Asp Glu Asn Asp Asn Ser Pro Glu Val Ile Val Thr 
            340                 345                 350         


Ser Leu Ser Leu Pro Val Lys Glu Asp Ala Gln Val Gly Thr Val Ile 
        355                 360                 365             


Ala Leu Ile Ser Val Ser Asp His Asp Ser Gly Ala Asn Gly Gln Val 
    370                 375                 380                 


Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr Tyr 
385                 390                 395                 400 


Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu Arg 
                405                 410                 415     


Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser Pro 
            420                 425                 430         


Pro Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Ala Phe Ala Gln Ser Glu Tyr Thr Val Phe Val Lys 
    450                 455                 460                 


Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Trp Asp 
465                 470                 475                 480 


Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu Arg 
                485                 490                 495     


Arg Leu Gly Glu Arg Ser Leu Ser Ser Tyr Val Ser Val His Ala Glu 
            500                 505                 510         


Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu Glu 
        515                 520                 525             


Leu Leu Gln Phe Gln Pro Arg Gln Pro Asn Pro Asp Trp Arg Tyr Ser 
    530                 535                 540                 


Ala Ser Leu Arg Ala Gly Met His Ser Ser Val His Leu Glu Glu Ala 
545                 550                 555                 560 


Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro Asp Gln Gln Trp Pro Thr 
                565                 570                 575     


Val Ser Ser Ala Thr Pro Glu Pro Glu Ala Gly Glu Val Ser Pro Pro 
            580                 585                 590         


Val Gly Ala Gly Val Asn Ser Asn Ser Trp Thr Phe Lys Tyr Gly Pro 
        595                 600                 605             


Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu Leu Pro Asp Lys Phe Ile 
    610                 615                 620                 


Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile Arg Gln Glu Pro Thr Asn 
625                 630                 635                 640 


Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr Phe Gly Lys Lys Glu Glu 
                645                 650                 655     


Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly Asn Lys Thr Gln Glu Lys 
            660                 665                 670         


Lys Glu Lys Gly Asn Ser Thr Thr Asp Asn Ser Asp Gln 
        675                 680                 685 


<210>  10093
<211>  949
<212>  PRT
<213>  Homo Sapiens

<400>  10093

Met Phe Gly Phe Gln Arg Arg Gly Leu Gly Thr Pro Arg Leu Gln Leu 
1               5                   10                  15      


Trp Leu Leu Leu Leu Glu Phe Trp Glu Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Ser Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Gln Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Thr His Gly Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Gln Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asn Val Glu Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Ser Leu Arg Glu Gln Lys Leu Leu Ile Ala Glu 
    130                 135                 140                 


Ser Lys Gln Ser Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Glu Glu Asn Ala Leu Leu Thr Tyr Arg Leu Ser Lys Asn Glu 
                165                 170                 175     


Tyr Phe Ser Leu Asp Ser Pro Thr Asn Gly Lys Gln Ile Lys Arg Leu 
            180                 185                 190         


Ser Leu Ile Leu Lys Lys Ser Leu Asp Arg Glu Lys Thr Pro Glu Leu 
        195                 200                 205             


Asn Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Arg Leu Leu Val Gln Val Leu Asp Val Asn Asp Asn Asp Pro 
225                 230                 235                 240 


Glu Phe Asp Lys Ser Glu Tyr Lys Val Ser Leu Met Glu Asn Ala Ala 
                245                 250                 255     


Lys Glu Thr Leu Val Leu Lys Leu Asn Ala Thr Asp Arg Asp Glu Gly 
            260                 265                 270         


Val Asn Gly Glu Val Thr Tyr Ser Leu Met Ser Ile Lys Pro Asn Gly 
        275                 280                 285             


Arg His Leu Phe Thr Leu Asp Gln Asn Asn Gly Glu Val Arg Val Asn 
    290                 295                 300                 


Gly Thr Leu Asp Tyr Glu Glu Asn Lys Phe Tyr Lys Ile Glu Val Gln 
305                 310                 315                 320 


Ala Thr Asp Lys Gly Thr Pro Pro Met Ala Gly His Cys Thr Val Trp 
                325                 330                 335     


Val Glu Ile Leu Asp Thr Asn Asp Asn Ser Pro Glu Val Ala Val Thr 
            340                 345                 350         


Ser Leu Ser Leu Pro Val Arg Glu Asp Ala Gln Pro Ser Thr Val Ile 
        355                 360                 365             


Ala Leu Ile Ser Val Ser Asp Arg Asp Ser Gly Val Asn Gly Gln Val 
    370                 375                 380                 


Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr Phe 
385                 390                 395                 400 


Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu Asn 
                405                 410                 415     


Val Trp Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser Pro 
            420                 425                 430         


Ser Leu Trp Ala Thr Ala Arg Val Ser Val Glu Val Ala Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val Lys 
    450                 455                 460                 


Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg Asp 
465                 470                 475                 480 


Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu Arg 
                485                 490                 495     


Arg Leu Gly Asp Arg Ala Leu Ser Ser Tyr Val Ser Val His Ala Glu 
            500                 505                 510         


Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu Glu 
        515                 520                 525             


Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro Leu 
    530                 535                 540                 


Ser Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp Asn 
545                 550                 555                 560 


Ala Pro Ala Leu Leu Ala Thr Gln Ala Gly Ser Ala Gly Gly Ala Val 
                565                 570                 575     


Asn Lys Leu Val Pro Arg Ser Val Gly Ala Gly His Val Val Ala Lys 
            580                 585                 590         


Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser Tyr 
        595                 600                 605             


Glu Leu Gln Pro Ala Ala Gly Gly Ser Arg Ile Pro Phe Arg Val Gly 
    610                 615                 620                 


Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Ala Asp 
625                 630                 635                 640 


Ser Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu Pro 
                645                 650                 655     


Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser Gly 
            660                 665                 670         


Gln Ala Pro Lys Ala Ser Ser Arg Thr Leu Ala Gly Ala Ala Ser Pro 
        675                 680                 685             


Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile Cys 
    690                 695                 700                 


Val Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala Leu 
705                 710                 715                 720 


Trp Trp Ser Ala Thr Pro Thr Glu Gly Ala Cys Ala Pro Gly Lys Pro 
                725                 730                 735     


Thr Leu Val Cys Ser Arg Ala Val Gly Ser Trp Ser Tyr Ser Gln Gln 
            740                 745                 750         


Arg Arg Gln Arg Val Cys Ser Glu Glu Gly Pro Pro Lys Thr Asp Leu 
        755                 760                 765             


Met Ala Phe Ser Pro Ser Leu Pro Leu Gly Leu Asn Lys Glu Glu Glu 
    770                 775                 780                 


Gly Glu Arg Gln Glu Pro Gly Ser Asn His Pro Gly Gln Pro Arg Gln 
785                 790                 795                 800 


Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His 
                805                 810                 815     


Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly 
            820                 825                 830         


Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro 
        835                 840                 845             


Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn 
    850                 855                 860                 


Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro 
865                 870                 875                 880 


Gly Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile 
                885                 890                 895     


Ser Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe 
            900                 905                 910         


Ile Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys 
        915                 920                 925             


Lys Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr 
    930                 935                 940                 


Asp Asn Ser Asp Gln 
945                 


<210>  10094
<211>  810
<212>  PRT
<213>  Homo Sapiens

<400>  10094

Met Phe Gly Phe Gln Arg Arg Gly Leu Gly Thr Pro Arg Leu Gln Leu 
1               5                   10                  15      


Trp Leu Leu Leu Leu Glu Phe Trp Glu Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Ser Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Gln Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Thr His Gly Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Gln Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asn Val Glu Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Ser Leu Arg Glu Gln Lys Leu Leu Ile Ala Glu 
    130                 135                 140                 


Ser Lys Gln Ser Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Glu Glu Asn Ala Leu Leu Thr Tyr Arg Leu Ser Lys Asn Glu 
                165                 170                 175     


Tyr Phe Ser Leu Asp Ser Pro Thr Asn Gly Lys Gln Ile Lys Arg Leu 
            180                 185                 190         


Ser Leu Ile Leu Lys Lys Ser Leu Asp Arg Glu Lys Thr Pro Glu Leu 
        195                 200                 205             


Asn Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Arg Leu Leu Val Gln Val Leu Asp Val Asn Asp Asn Asp Pro 
225                 230                 235                 240 


Glu Phe Asp Lys Ser Glu Tyr Lys Val Ser Leu Met Glu Asn Ala Ala 
                245                 250                 255     


Lys Glu Thr Leu Val Leu Lys Leu Asn Ala Thr Asp Arg Asp Glu Gly 
            260                 265                 270         


Val Asn Gly Glu Val Thr Tyr Ser Leu Met Ser Ile Lys Pro Asn Gly 
        275                 280                 285             


Arg His Leu Phe Thr Leu Asp Gln Asn Asn Gly Glu Val Arg Val Asn 
    290                 295                 300                 


Gly Thr Leu Asp Tyr Glu Glu Asn Lys Phe Tyr Lys Ile Glu Val Gln 
305                 310                 315                 320 


Ala Thr Asp Lys Gly Thr Pro Pro Met Ala Gly His Cys Thr Val Trp 
                325                 330                 335     


Val Glu Ile Leu Asp Thr Asn Asp Asn Ser Pro Glu Val Ala Val Thr 
            340                 345                 350         


Ser Leu Ser Leu Pro Val Arg Glu Asp Ala Gln Pro Ser Thr Val Ile 
        355                 360                 365             


Ala Leu Ile Ser Val Ser Asp Arg Asp Ser Gly Val Asn Gly Gln Val 
    370                 375                 380                 


Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr Phe 
385                 390                 395                 400 


Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu Asn 
                405                 410                 415     


Val Trp Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser Pro 
            420                 425                 430         


Ser Leu Trp Ala Thr Ala Arg Val Ser Val Glu Val Ala Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val Lys 
    450                 455                 460                 


Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg Asp 
465                 470                 475                 480 


Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu Arg 
                485                 490                 495     


Arg Leu Gly Asp Arg Ala Leu Ser Ser Tyr Val Ser Val His Ala Glu 
            500                 505                 510         


Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu Glu 
        515                 520                 525             


Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro Leu 
    530                 535                 540                 


Ser Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp Asn 
545                 550                 555                 560 


Ala Pro Ala Leu Leu Ala Thr Gln Ala Gly Ser Ala Gly Gly Ala Val 
                565                 570                 575     


Asn Lys Leu Val Pro Arg Ser Val Gly Ala Gly His Val Val Ala Lys 
            580                 585                 590         


Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser Tyr 
        595                 600                 605             


Glu Leu Gln Pro Ala Ala Gly Gly Ser Arg Ile Pro Phe Arg Val Gly 
    610                 615                 620                 


Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Ala Asp 
625                 630                 635                 640 


Ser Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu Pro 
                645                 650                 655     


Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser Gly 
            660                 665                 670         


Gln Ala Pro Lys Ala Ser Ser Arg Thr Leu Ala Gly Ala Ala Ser Pro 
        675                 680                 685             


Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile Cys 
    690                 695                 700                 


Val Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala Leu 
705                 710                 715                 720 


Trp Trp Ser Ala Thr Pro Thr Glu Gly Ala Cys Ala Pro Gly Lys Pro 
                725                 730                 735     


Thr Leu Val Cys Ser Arg Ala Val Gly Ser Trp Ser Tyr Ser Gln Gln 
            740                 745                 750         


Arg Arg Gln Arg Val Cys Ser Glu Glu Gly Pro Pro Lys Thr Asp Leu 
        755                 760                 765             


Met Ala Phe Ser Pro Ser Leu Pro Leu Gly Leu Asn Lys Glu Glu Glu 
    770                 775                 780                 


Gly Glu Arg Gln Glu Pro Gly Ser Asn His Pro Gly Gln Val Ser Phe 
785                 790                 795                 800 


Leu Gln Ile Pro Pro Ile Arg Lys Cys Met 
                805                 810 


<210>  10095
<211>  199
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  10095

Xaa Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala Leu 
1               5                   10                  15      


Trp Trp Ser Ala Thr Pro Thr Glu Gly Ala Cys Ala Pro Gly Lys Pro 
            20                  25                  30          


Thr Leu Val Cys Ser Arg Ala Val Gly Ser Trp Ser Tyr Ser Gln Gln 
        35                  40                  45              


Arg Arg Gln Arg Val Cys Ser Glu Glu Gly Pro Pro Lys Thr Asp Leu 
    50                  55                  60                  


Met Ala Phe Ser Pro Ser Leu Pro Leu Gly Leu Asn Lys Glu Glu Glu 
65                  70                  75                  80  


Gly Glu Arg Gln Glu Pro Gly Ser Asn His Pro Gly Gln Pro Arg Gln 
                85                  90                  95      


Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His 
            100                 105                 110         


Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly 
        115                 120                 125             


Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro 
    130                 135                 140                 


Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn 
145                 150                 155                 160 


Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro 
                165                 170                 175     


Glu Pro Lys Lys Gln Thr Gln Val Ser Phe Leu Leu Arg Arg Lys Gly 
            180                 185                 190         


Glu Ala Ser Gln Pro Arg Gln 
        195                 


<210>  10096
<211>  803
<212>  PRT
<213>  Homo Sapiens

<400>  10096

Met Val Phe Thr Pro Glu Asp Arg Leu Gly Lys Gln Cys Leu Leu Leu 
1               5                   10                  15      


Pro Leu Leu Leu Leu Ala Ala Trp Lys Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Met Ala Ser Lys Asp Arg Glu Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asp Val Glu Val Arg Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Leu Phe Pro Val Glu Glu Gln Arg Val Leu Ile Tyr Glu 
    130                 135                 140                 


Ser Arg Leu Pro Asp Ser Val Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Val Gly Ser Asn Ser Ile Leu Thr Tyr Lys Leu Ser Ser Ser Glu 
                165                 170                 175     


Tyr Phe Gly Leu Asp Val Lys Ile Asn Ser Asp Asp Asn Lys Gln Ile 
            180                 185                 190         


Gly Leu Leu Leu Lys Lys Ser Leu Asp Arg Glu Glu Ala Pro Ala His 
        195                 200                 205             


Asn Leu Phe Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Leu Leu Val Thr Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Thr Phe Glu Gln Ser Glu Tyr Glu Val Arg Ile Phe Glu Asn Ala Asp 
                245                 250                 255     


Asn Gly Thr Thr Val Ile Arg Leu Asn Ala Ser Asp Arg Asp Glu Gly 
            260                 265                 270         


Ala Asn Gly Ala Ile Ser Tyr Ser Phe Asn Ser Leu Val Ala Ala Met 
        275                 280                 285             


Val Ile Asp His Phe Ser Ile Asp Arg Asn Thr Gly Glu Ile Val Ile 
    290                 295                 300                 


Arg Gly Asn Leu Asp Phe Glu Gln Glu Asn Leu Tyr Lys Ile Leu Ile 
305                 310                 315                 320 


Asp Ala Thr Asp Lys Gly His Pro Pro Met Ala Gly His Cys Thr Val 
                325                 330                 335     


Leu Val Arg Ile Leu Asp Lys Asn Asp Asn Val Pro Glu Ile Ala Leu 
            340                 345                 350         


Thr Ser Leu Ser Leu Pro Val Arg Glu Asp Ala Gln Phe Gly Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Asn Asp Leu Asp Ser Gly Ala Asn Gly Gln 
    370                 375                 380                 


Val Asn Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Ser Leu Ser Val Glu Val Ala Asp Met 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Ser Tyr Ile Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Ala Pro Arg Val Gly Gly Thr Gly Gly Ala 
                565                 570                 575     


Val Ser Glu Leu Val Pro Arg Ser Leu Gly Ala Gly Gln Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Pro Ala Ser Ser Ala Arg Phe Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Val Leu Asp Glu Ala 
625                 630                 635                 640 


Asp Ser Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ala Ser Ser Arg Ala Ser Val Gly Ala Ala Gly 
        675                 680                 685             


Pro Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Pro Pro Thr Glu Gly Ala Cys Thr Ala Asp Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Arg Arg Gln Arg Val Cys Ser Gly Glu Gly Pro Pro Lys Met Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Ser Leu Ser Pro Cys Pro Ile Met Met Gly 
    770                 775                 780                 


Lys Ala Glu Asn Gln Asp Leu Asn Glu Asp His Asp Ala Lys Val Ser 
785                 790                 795                 800 


Glu Phe Ser 
            


<210>  10097
<211>  686
<212>  PRT
<213>  Homo Sapiens

<400>  10097

Met Val Phe Thr Pro Glu Asp Arg Leu Gly Lys Gln Cys Leu Leu Leu 
1               5                   10                  15      


Pro Leu Leu Leu Leu Ala Ala Trp Lys Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Met Ala Ser Lys Asp Arg Glu Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asp Val Glu Val Arg Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Leu Phe Pro Val Glu Glu Gln Arg Val Leu Ile Tyr Glu 
    130                 135                 140                 


Ser Arg Leu Pro Asp Ser Val Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Val Gly Ser Asn Ser Ile Leu Thr Tyr Lys Leu Ser Ser Ser Glu 
                165                 170                 175     


Tyr Phe Gly Leu Asp Val Lys Ile Asn Ser Asp Asp Asn Lys Gln Ile 
            180                 185                 190         


Gly Leu Leu Leu Lys Lys Ser Leu Asp Arg Glu Glu Ala Pro Ala His 
        195                 200                 205             


Asn Leu Phe Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Leu Leu Val Thr Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Thr Phe Glu Gln Ser Glu Tyr Glu Val Arg Ile Phe Glu Asn Ala Asp 
                245                 250                 255     


Asn Gly Thr Thr Val Ile Arg Leu Asn Ala Ser Asp Arg Asp Glu Gly 
            260                 265                 270         


Ala Asn Gly Ala Ile Ser Tyr Ser Phe Asn Ser Leu Val Ala Ala Met 
        275                 280                 285             


Val Ile Asp His Phe Ser Ile Asp Arg Asn Thr Gly Glu Ile Val Ile 
    290                 295                 300                 


Arg Gly Asn Leu Asp Phe Glu Gln Glu Asn Leu Tyr Lys Ile Leu Ile 
305                 310                 315                 320 


Asp Ala Thr Asp Lys Gly His Pro Pro Met Ala Gly His Cys Thr Val 
                325                 330                 335     


Leu Val Arg Ile Leu Asp Lys Asn Asp Asn Val Pro Glu Ile Ala Leu 
            340                 345                 350         


Thr Ser Leu Ser Leu Pro Val Arg Glu Asp Ala Gln Phe Gly Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Asn Asp Leu Asp Ser Gly Ala Asn Gly Gln 
    370                 375                 380                 


Val Asn Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Ser Leu Ser Val Glu Val Ala Asp Met 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Ser Tyr Ile Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Pro Arg Gln Pro Asn Pro Asp Trp Arg Tyr 
    530                 535                 540                 


Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser Val His Leu Glu Glu 
545                 550                 555                 560 


Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro Asp Gln Gln Trp Pro 
                565                 570                 575     


Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala Gly Glu Val Ser Pro 
            580                 585                 590         


Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp Thr Phe Lys Tyr Gly 
        595                 600                 605             


Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu Leu Pro Asp Lys Phe 
    610                 615                 620                 


Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile Arg Gln Glu Pro Thr 
625                 630                 635                 640 


Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr Phe Gly Lys Lys Glu 
                645                 650                 655     


Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly Asn Lys Thr Gln Glu 
            660                 665                 670         


Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp Asn Ser Asp Gln 
        675                 680                 685     


<210>  10098
<211>  950
<212>  PRT
<213>  Homo Sapiens

<400>  10098

Met Val Phe Thr Pro Glu Asp Arg Leu Gly Lys Gln Cys Leu Leu Leu 
1               5                   10                  15      


Pro Leu Leu Leu Leu Ala Ala Trp Lys Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Met Ala Ser Lys Asp Arg Glu Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asp Val Glu Val Arg Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Leu Phe Pro Val Glu Glu Gln Arg Val Leu Ile Tyr Glu 
    130                 135                 140                 


Ser Arg Leu Pro Asp Ser Val Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Val Gly Ser Asn Ser Ile Leu Thr Tyr Lys Leu Ser Ser Ser Glu 
                165                 170                 175     


Tyr Phe Gly Leu Asp Val Lys Ile Asn Ser Asp Asp Asn Lys Gln Ile 
            180                 185                 190         


Gly Leu Leu Leu Lys Lys Ser Leu Asp Arg Glu Glu Ala Pro Ala His 
        195                 200                 205             


Asn Leu Phe Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Leu Leu Val Thr Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Thr Phe Glu Gln Ser Glu Tyr Glu Val Arg Ile Phe Glu Asn Ala Asp 
                245                 250                 255     


Asn Gly Thr Thr Val Ile Arg Leu Asn Ala Ser Asp Arg Asp Glu Gly 
            260                 265                 270         


Ala Asn Gly Ala Ile Ser Tyr Ser Phe Asn Ser Leu Val Ala Ala Met 
        275                 280                 285             


Val Ile Asp His Phe Ser Ile Asp Arg Asn Thr Gly Glu Ile Val Ile 
    290                 295                 300                 


Arg Gly Asn Leu Asp Phe Glu Gln Glu Asn Leu Tyr Lys Ile Leu Ile 
305                 310                 315                 320 


Asp Ala Thr Asp Lys Gly His Pro Pro Met Ala Gly His Cys Thr Val 
                325                 330                 335     


Leu Val Arg Ile Leu Asp Lys Asn Asp Asn Val Pro Glu Ile Ala Leu 
            340                 345                 350         


Thr Ser Leu Ser Leu Pro Val Arg Glu Asp Ala Gln Phe Gly Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Asn Asp Leu Asp Ser Gly Ala Asn Gly Gln 
    370                 375                 380                 


Val Asn Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Ser Leu Ser Val Glu Val Ala Asp Met 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Ser Tyr Ile Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Ala Pro Arg Val Gly Gly Thr Gly Gly Ala 
                565                 570                 575     


Val Ser Glu Leu Val Pro Arg Ser Leu Gly Ala Gly Gln Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Pro Ala Ser Ser Ala Arg Phe Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Val Leu Asp Glu Ala 
625                 630                 635                 640 


Asp Ser Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ala Ser Ser Arg Ala Ser Val Gly Ala Ala Gly 
        675                 680                 685             


Pro Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Pro Pro Thr Glu Gly Ala Cys Thr Ala Asp Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Arg Arg Gln Arg Val Cys Ser Gly Glu Gly Pro Pro Lys Met Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Ser Leu Ser Pro Cys Pro Ile Met Met Gly 
    770                 775                 780                 


Lys Ala Glu Asn Gln Asp Leu Asn Glu Asp His Asp Ala Lys Pro Arg 
785                 790                 795                 800 


Gln Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met 
                805                 810                 815     


His Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro 
            820                 825                 830         


Gly Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu 
        835                 840                 845             


Pro Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser 
    850                 855                 860                 


Asn Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly 
865                 870                 875                 880 


Pro Gly Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile 
                885                 890                 895     


Ile Ser Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp 
            900                 905                 910         


Phe Ile Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys 
        915                 920                 925             


Lys Lys Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr 
    930                 935                 940                 


Thr Asp Asn Ser Asp Gln 
945                 950 


<210>  10099
<211>  458
<212>  PRT
<213>  Homo Sapiens

<400>  10099

Met Asp Val Asn Asp Asn Ala Pro Glu Ile Thr Val Ser Ser Ile Thr 
1               5                   10                  15      


Ser Pro Ile Pro Glu Asn Thr Pro Glu Thr Val Val Met Val Phe Arg 
            20                  25                  30          


Ile Arg Asp Arg Asp Ser Gly Asp Asn Gly Lys Met Val Cys Ser Ile 
        35                  40                  45              


Pro Glu Asp Ile Pro Phe Val Leu Lys Ser Ser Val Asn Asn Tyr Tyr 
    50                  55                  60                  


Thr Leu Glu Thr Glu Arg Pro Leu Asp Arg Glu Ser Arg Ala Glu Tyr 
65                  70                  75                  80  


Asn Ile Thr Ile Thr Val Thr Asp Leu Gly Thr Pro Arg Leu Lys Thr 
                85                  90                  95      


Glu His Asn Ile Thr Val Leu Val Ser Asp Val Asn Asp Asn Ala Pro 
            100                 105                 110         


Ala Phe Thr Gln Thr Ser Tyr Ala Leu Phe Val Arg Glu Asn Asn Ser 
        115                 120                 125             


Pro Ala Leu His Ile Gly Ser Ile Ser Ala Thr Asp Arg Asp Ser Gly 
    130                 135                 140                 


Thr Asn Ala Gln Val Asn Tyr Ser Leu Leu Pro Ser Gln Asp Pro His 
145                 150                 155                 160 


Leu Pro Leu Ala Ser Leu Val Ser Ile Asn Ala Asp Asn Gly His Leu 
                165                 170                 175     


Phe Ala Leu Arg Ser Leu Asp Tyr Glu Ala Leu Gln Gly Phe Gln Phe 
            180                 185                 190         


Arg Val Gly Ala Thr Asp His Gly Ser Pro Ala Leu Ser Ser Glu Ala 
        195                 200                 205             


Leu Val Arg Val Leu Val Leu Asp Ala Asn Asp Asn Ser Pro Phe Val 
    210                 215                 220                 


Leu Tyr Pro Leu Gln Asn Gly Ser Ala Pro Cys Thr Glu Leu Val Pro 
225                 230                 235                 240 


Trp Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val Asp 
                245                 250                 255     


Gly Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Gln Leu Leu Lys Ala 
            260                 265                 270         


Thr Glu Pro Gly Leu Phe Gly Val Trp Ala His Asn Gly Glu Val Arg 
        275                 280                 285             


Thr Ala Arg Leu Leu Ser Glu Arg Asp Ala Ala Lys His Arg Leu Val 
    290                 295                 300                 


Val Leu Val Lys Asp Asn Gly Glu Pro Pro Arg Ser Ala Thr Ala Thr 
305                 310                 315                 320 


Leu His Val Leu Leu Val Asp Gly Phe Ser Gln Pro Tyr Leu Pro Leu 
                325                 330                 335     


Pro Glu Ala Ala Pro Ala Gln Ala Gln Ala Asp Ser Leu Thr Val Tyr 
            340                 345                 350         


Leu Val Val Ala Leu Ala Ser Val Ser Ser Leu Phe Leu Phe Ser Val 
        355                 360                 365             


Leu Leu Phe Val Ala Val Arg Leu Cys Arg Arg Ser Arg Ala Ala Pro 
    370                 375                 380                 


Val Gly Arg Cys Ser Val Pro Glu Gly Pro Phe Pro Gly His Leu Val 
385                 390                 395                 400 


Asp Val Ser Gly Thr Gly Thr Leu Ser Gln Ser Tyr His Tyr Glu Val 
                405                 410                 415     


Cys Val Thr Gly Gly Ser Arg Ser Asn Lys Phe Lys Phe Leu Lys Pro 
            420                 425                 430         


Ile Ile Pro Asn Phe Leu Pro Gln Ser Thr Gly Ser Glu Val Glu Glu 
        435                 440                 445             


Asn Pro Pro Phe Gln Asn Asn Leu Gly Phe 
    450                 455             


<210>  10100
<211>  67
<212>  PRT
<213>  Homo Sapiens

<400>  10100

Met Glu Asn Gly Gly Ala Gly Thr Leu Gln Ile Arg Gln Val Leu Leu 
1               5                   10                  15      


Phe Phe Val Leu Leu Gly Met Ser Gln Ala Gly Ser Glu Thr Gly Asn 
            20                  25                  30          


Phe Leu Val Met Glu Glu Leu Gln Ser Gly Ser Phe Val Gly Asn Leu 
        35                  40                  45              


Ala Lys Thr Leu Gly Leu Glu His Leu Trp Ile Leu Lys Gln Leu Ser 
    50                  55                  60                  


His Thr Gln 
65          


<210>  10101
<211>  795
<212>  PRT
<213>  Homo Sapiens

<400>  10101

Met Glu Asn Gly Gly Ala Gly Thr Leu Gln Ile Arg Gln Val Leu Leu 
1               5                   10                  15      


Phe Phe Val Leu Leu Gly Met Ser Gln Ala Gly Ser Glu Thr Gly Asn 
            20                  25                  30          


Phe Leu Val Met Glu Glu Leu Gln Ser Gly Ser Phe Val Gly Asn Leu 
        35                  40                  45              


Ala Lys Thr Leu Gly Leu Glu Val Ser Glu Leu Ser Ser Arg Gly Ala 
    50                  55                  60                  


Arg Val Val Ser Asn Asp Asn Lys Glu Cys Leu Gln Leu Asp Thr Asn 
65                  70                  75                  80  


Thr Gly Asp Leu Leu Leu Arg Glu Met Leu Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Ser Asn Glu Pro Cys Val Leu Tyr Phe Gln Val Leu Met Lys Asn 
            100                 105                 110         


Pro Thr Gln Phe Leu Gln Ile Glu Leu Gln Val Arg Asp Ile Asn Asp 
        115                 120                 125             


His Ser Pro Val Phe Leu Glu Lys Glu Met Leu Leu Glu Ile Pro Glu 
    130                 135                 140                 


Asn Ser Pro Val Gly Ala Val Phe Leu Leu Glu Ser Ala Lys Asp Leu 
145                 150                 155                 160 


Asp Val Gly Ile Asn Ala Val Lys Ser Tyr Thr Ile Asn Pro Asn Ser 
                165                 170                 175     


His Phe His Val Lys Ile Arg Val Asn Pro Asp Asn Arg Lys Tyr Pro 
            180                 185                 190         


Glu Leu Val Leu Asp Lys Ala Leu Asp Tyr Glu Glu Arg Pro Glu Leu 
        195                 200                 205             


Ser Phe Ile Leu Thr Ala Leu Asp Gly Gly Ser Pro Pro Arg Ser Gly 
    210                 215                 220                 


Thr Ala Leu Val Arg Val Val Val Val Asp Ile Asn Asp Asn Ser Pro 
225                 230                 235                 240 


Glu Phe Glu Gln Ala Phe Tyr Glu Val Lys Ile Leu Glu Asn Ser Ile 
                245                 250                 255     


Leu Gly Ser Leu Val Val Thr Val Ser Ala Trp Asp Leu Asp Ser Gly 
            260                 265                 270         


Thr Asn Ser Glu Leu Ser Tyr Thr Phe Ser His Ala Ser Glu Asp Ile 
        275                 280                 285             


Arg Lys Thr Phe Glu Ile Asn Gln Lys Ser Gly Asp Ile Thr Leu Thr 
    290                 295                 300                 


Ala Pro Leu Asp Phe Glu Ala Ile Glu Ser Tyr Ser Ile Ile Ile Gln 
305                 310                 315                 320 


Ala Thr Asp Gly Gly Gly Leu Phe Gly Lys Ser Thr Val Arg Ile Gln 
                325                 330                 335     


Val Met Asp Val Asn Asp Asn Ala Pro Glu Ile Thr Val Ser Ser Ile 
            340                 345                 350         


Thr Ser Pro Ile Pro Glu Asn Thr Pro Glu Thr Val Val Met Val Phe 
        355                 360                 365             


Arg Ile Arg Asp Arg Asp Ser Gly Asp Asn Gly Lys Met Val Cys Ser 
    370                 375                 380                 


Ile Pro Glu Asp Ile Pro Phe Val Leu Lys Ser Ser Val Asn Asn Tyr 
385                 390                 395                 400 


Tyr Thr Leu Glu Thr Glu Arg Pro Leu Asp Arg Glu Ser Arg Ala Glu 
                405                 410                 415     


Tyr Asn Ile Thr Ile Thr Val Thr Asp Leu Gly Thr Pro Arg Leu Lys 
            420                 425                 430         


Thr Glu His Asn Ile Thr Val Leu Val Ser Asp Val Asn Asp Asn Ala 
        435                 440                 445             


Pro Ala Phe Thr Gln Thr Ser Tyr Ala Leu Phe Val Arg Glu Asn Asn 
    450                 455                 460                 


Ser Pro Ala Leu His Ile Gly Ser Ile Ser Ala Thr Asp Arg Asp Ser 
465                 470                 475                 480 


Gly Thr Asn Ala Gln Val Asn Tyr Ser Leu Leu Pro Ser Gln Asp Pro 
                485                 490                 495     


His Leu Pro Leu Ala Ser Leu Val Ser Ile Asn Ala Asp Asn Gly His 
            500                 505                 510         


Leu Phe Ala Leu Arg Ser Leu Asp Tyr Glu Ala Leu Gln Gly Phe Gln 
        515                 520                 525             


Phe Arg Val Gly Ala Thr Asp His Gly Ser Pro Ala Leu Ser Ser Glu 
    530                 535                 540                 


Ala Leu Val Arg Val Leu Val Leu Asp Ala Asn Asp Asn Ser Pro Phe 
545                 550                 555                 560 


Val Leu Tyr Pro Leu Gln Asn Gly Ser Ala Pro Cys Thr Glu Leu Val 
                565                 570                 575     


Pro Trp Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val 
            580                 585                 590         


Asp Gly Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Gln Leu Leu Lys 
        595                 600                 605             


Ala Thr Glu Pro Gly Leu Phe Gly Val Trp Ala His Asn Gly Glu Val 
    610                 615                 620                 


Arg Thr Ala Arg Leu Leu Ser Glu Arg Asp Ala Ala Lys His Arg Leu 
625                 630                 635                 640 


Val Val Leu Val Lys Asp Asn Gly Glu Pro Pro Arg Ser Ala Thr Ala 
                645                 650                 655     


Thr Leu His Val Leu Leu Val Asp Gly Phe Ser Gln Pro Tyr Leu Pro 
            660                 665                 670         


Leu Pro Glu Ala Ala Pro Ala Gln Ala Gln Ala Asp Ser Leu Thr Val 
        675                 680                 685             


Tyr Leu Val Val Ala Leu Ala Ser Val Ser Ser Leu Phe Leu Phe Ser 
    690                 695                 700                 


Val Leu Leu Phe Val Ala Val Arg Leu Cys Arg Arg Ser Arg Ala Ala 
705                 710                 715                 720 


Pro Val Gly Arg Cys Ser Val Pro Glu Gly Pro Phe Pro Gly His Leu 
                725                 730                 735     


Val Asp Val Ser Gly Thr Gly Thr Leu Ser Gln Ser Tyr His Tyr Glu 
            740                 745                 750         


Val Cys Val Thr Gly Gly Ser Arg Ser Asn Lys Phe Lys Phe Leu Lys 
        755                 760                 765             


Pro Ile Ile Pro Asn Phe Leu Pro Gln Ser Thr Gly Ser Glu Val Glu 
    770                 775                 780                 


Glu Asn Pro Pro Phe Gln Asn Asn Leu Gly Phe 
785                 790                 795 


<210>  10102
<211>  935
<212>  PRT
<213>  Homo Sapiens

<400>  10102

Met Ala Asn Arg Leu Gln Arg Gly Asp Arg Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Cys Ile Phe Leu Gly Thr Leu Arg Gly Phe Arg Ala Arg Gln Ile 
            20                  25                  30          


Arg Tyr Ser Val Pro Glu Glu Thr Glu Lys Gly Ser Phe Val Gly Asn 
        35                  40                  45              


Ile Ser Lys Asp Leu Gly Leu Glu Pro Arg Glu Leu Ala Lys Arg Gly 
    50                  55                  60                  


Val Arg Ile Val Ser Arg Gly Lys Thr Gln Leu Phe Ala Val Asn Pro 
65                  70                  75                  80  


Arg Ser Gly Ser Leu Ile Thr Ala Gly Arg Ile Asp Arg Glu Glu Leu 
                85                  90                  95      


Cys Glu Thr Val Ser Ser Cys Phe Leu Asn Met Glu Leu Leu Val Glu 
            100                 105                 110         


Asp Thr Leu Lys Ile Tyr Gly Val Glu Val Glu Ile Ile Asp Ile Asn 
        115                 120                 125             


Asp Asn Ala Pro Ser Phe Gln Glu Asp Glu Val Glu Ile Lys Val Ser 
    130                 135                 140                 


Glu His Ala Ile Pro Gly Ala Arg Phe Ala Leu Pro Asn Ala Arg Asp 
145                 150                 155                 160 


Pro Asp Val Gly Val Asn Ser Leu Gln Ser Tyr Gln Leu Ser Pro Asn 
                165                 170                 175     


Asn Tyr Phe Ser Leu Gln Leu Arg Gly Arg Thr Asp Gly Ala Lys Asn 
            180                 185                 190         


Pro Glu Leu Val Leu Glu Gly Ser Leu Asp Arg Glu Lys Glu Ala Ala 
        195                 200                 205             


His Leu Leu Leu Leu Thr Ala Leu Asp Gly Gly Asp Pro Ile Arg Lys 
    210                 215                 220                 


Gly Ala Val Pro Ile Arg Val Val Val Leu Asp Val Asn Asp His Ile 
225                 230                 235                 240 


Pro Met Phe Thr Gln Ser Val Tyr Arg Val Ser Val Pro Glu Asn Ile 
                245                 250                 255     


Ser Ser Gly Thr Arg Val Leu Met Val Asn Ala Thr Asp Pro Asp Glu 
            260                 265                 270         


Gly Ile Asn Gly Glu Val Met Tyr Ser Phe Arg Asn Met Glu Ser Lys 
        275                 280                 285             


Ala Ser Glu Ile Phe Gln Leu Asp Ser Gln Thr Gly Glu Val Gln Val 
    290                 295                 300                 


Arg Gly Ser Leu Asp Phe Glu Lys Tyr Arg Phe Tyr Glu Met Glu Ile 
305                 310                 315                 320 


Gln Gly Gln Asp Gly Gly Gly Leu Phe Thr Thr Thr Thr Met Leu Ile 
                325                 330                 335     


Thr Val Val Asp Val Asn Asp Asn Ala Pro Glu Ile Thr Ile Thr Ser 
            340                 345                 350         


Ser Ile Asn Ser Ile Leu Glu Asn Ser Pro Pro Gly Thr Val Ile Ala 
        355                 360                 365             


Leu Leu Asn Val Gln Asp Gln Asp Ser Gly Glu Asn Gly Gln Val Ser 
    370                 375                 380                 


Cys Phe Ile Pro Asn His Leu Pro Phe Lys Leu Glu Lys Thr Tyr Gly 
385                 390                 395                 400 


Asn Tyr Tyr Lys Leu Ile Thr Ser Arg Val Leu Asp Arg Glu Leu Val 
                405                 410                 415     


Gln Ser Tyr Asn Ile Thr Leu Thr Ala Thr Asp Gln Gly Ser Pro Pro 
            420                 425                 430         


Leu Ser Ala Glu Thr His Val Trp Leu Asn Val Ala Asp Asp Asn Asp 
        435                 440                 445             


Asn Pro Pro Val Phe Pro His Ser Ser Tyr Ser Ala Tyr Ile Pro Glu 
    450                 455                 460                 


Asn Asn Pro Arg Gly Ala Ser Ile Phe Ser Val Thr Ala Leu Asp Pro 
465                 470                 475                 480 


Asp Ser Lys Gln Asn Ala Leu Val Thr Tyr Ser Leu Thr Asp Asp Thr 
                485                 490                 495     


Val Gln Gly Val Pro Leu Ser Ser Tyr Val Ser Ile Asn Ser Asn Thr 
            500                 505                 510         


Gly Val Leu Tyr Ala Leu Gln Ser Phe Asp Tyr Glu Gln Phe Arg Asp 
        515                 520                 525             


Leu Glu Leu Arg Val Ile Ala Arg Asp Ser Gly Asp Pro Pro Leu Ser 
    530                 535                 540                 


Ser Asn Val Ser Leu Ser Leu Phe Val Leu Asp Gln Asn Asp Asn Ala 
545                 550                 555                 560 


Pro Glu Ile Leu Tyr Pro Ala Leu Pro Thr Asp Gly Ser Thr Gly Val 
                565                 570                 575     


Glu Leu Ala Pro Arg Ser Ala Glu Pro Gly Tyr Leu Val Thr Lys Val 
            580                 585                 590         


Val Ala Val Asp Lys Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Arg 
        595                 600                 605             


Leu Leu Lys Ala Ser Glu Pro Gly Leu Phe Ala Val Gly Glu His Thr 
    610                 615                 620                 


Gly Glu Val Arg Thr Ala Arg Ala Leu Leu Asp Arg Asp Ala Leu Lys 
625                 630                 635                 640 


Gln Ser Leu Val Val Ala Val Gln Asp His Gly Gln Pro Pro Leu Ser 
                645                 650                 655     


Ala Thr Val Thr Leu Thr Val Ala Val Ala Asp Ser Ile Pro Glu Val 
            660                 665                 670         


Leu Ala Asp Leu Gly Ser Leu Glu Ser Leu Ala Asn Ser Glu Thr Ser 
        675                 680                 685             


Asp Leu Ser Leu Tyr Leu Val Val Ala Val Ala Ala Val Ser Cys Ile 
    690                 695                 700                 


Phe Leu Val Phe Val Ile Val Leu Leu Ala Leu Arg Leu Trp Arg Trp 
705                 710                 715                 720 


His Lys Ser Arg Leu Leu Gln Ala Ser Glu Gly Gly Leu Ala Gly Met 
                725                 730                 735     


Pro Thr Ser His Phe Val Gly Val Asp Gly Val Gln Ala Phe Leu Gln 
            740                 745                 750         


Thr Tyr Ser His Glu Val Ser Leu Ile Ala Asp Ser Gln Lys Ser His 
        755                 760                 765             


Leu Ile Phe Pro Gln Pro Asn Tyr Gly Asp Thr Leu Ile Ser Gln Glu 
    770                 775                 780                 


Ser Cys Glu Lys Ser Glu Pro Leu Leu Ile Ala Glu Asp Ser Ala Ile 
785                 790                 795                 800 


Ile Leu Gly Lys Cys Asp Pro Thr Ser Asn Gln Gln Ala Pro Pro Asn 
                805                 810                 815     


Thr Asp Trp Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser 
            820                 825                 830         


Gln Asn Gly Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr 
        835                 840                 845             


Glu Met Leu Gln Ala Met Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp 
    850                 855                 860                 


Gly Ser Ser Thr Leu Gly Gly Gly Ala Gly Thr Met Gly Leu Ser Ala 
865                 870                 875                 880 


Arg Tyr Gly Pro Gln Phe Thr Leu Gln His Val Pro Asp Tyr Arg Gln 
                885                 890                 895     


Asn Val Tyr Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly 
            900                 905                 910         


Lys Arg Asp Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys 
        915                 920                 925             


Ser Gly Lys Lys Glu Lys Lys 
    930                 935 


<210>  10103
<211>  750
<212>  PRT
<213>  Homo Sapiens

<400>  10103

Met Ala Asn Arg Leu Gln Arg Gly Asp Arg Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Cys Ile Phe Leu Gly Thr Leu Arg Gly Phe Arg Ala Arg Gln Ile 
            20                  25                  30          


Arg Tyr Ser Val Pro Glu Glu Thr Glu Lys Gly Ser Phe Val Gly Asn 
        35                  40                  45              


Ile Ser Lys Asp Leu Gly Leu Glu Pro Arg Glu Leu Ala Lys Arg Gly 
    50                  55                  60                  


Val Arg Ile Val Ser Arg Gly Lys Thr Gln Leu Phe Ala Val Asn Pro 
65                  70                  75                  80  


Arg Ser Gly Ser Leu Ile Thr Ala Gly Arg Ile Asp Arg Glu Glu Leu 
                85                  90                  95      


Cys Glu Thr Val Ser Ser Cys Phe Leu Asn Met Glu Leu Leu Val Glu 
            100                 105                 110         


Asp Thr Leu Lys Ile Tyr Gly Val Glu Val Glu Ile Ile Asp Ile Asn 
        115                 120                 125             


Asp Asn Ala Pro Ser Phe Gln Glu Asp Glu Val Glu Ile Lys Val Ser 
    130                 135                 140                 


Glu His Ala Ile Pro Gly Ala Arg Phe Ala Leu Pro Asn Ala Arg Asp 
145                 150                 155                 160 


Pro Asp Val Gly Val Asn Ser Leu Gln Ser Tyr Gln Leu Ser Pro Asn 
                165                 170                 175     


Asn Tyr Phe Ser Leu Gln Leu Arg Gly Arg Thr Asp Gly Ala Lys Asn 
            180                 185                 190         


Pro Glu Leu Val Leu Glu Gly Ser Leu Asp Arg Glu Lys Glu Ala Ala 
        195                 200                 205             


His Leu Leu Leu Leu Thr Ala Leu Asp Gly Gly Asp Pro Ile Arg Lys 
    210                 215                 220                 


Gly Ala Val Pro Ile Arg Val Val Val Leu Asp Val Asn Asp His Ile 
225                 230                 235                 240 


Pro Met Phe Thr Gln Ser Val Tyr Arg Val Ser Val Pro Glu Asn Ile 
                245                 250                 255     


Ser Ser Gly Thr Arg Val Leu Met Val Asn Ala Thr Asp Pro Asp Glu 
            260                 265                 270         


Gly Ile Asn Gly Glu Val Met Tyr Ser Phe Arg Asn Met Glu Ser Lys 
        275                 280                 285             


Ala Ser Glu Ile Phe Gln Leu Asp Ser Gln Thr Gly Glu Val Gln Val 
    290                 295                 300                 


Arg Gly Ser Leu Asp Phe Glu Lys Tyr Arg Phe Tyr Glu Met Glu Ile 
305                 310                 315                 320 


Gln Gly Gln Asp Gly Gly Gly Leu Phe Thr Thr Thr Thr Met Leu Ile 
                325                 330                 335     


Thr Val Val Asp Val Asn Asp Asn Ala Pro Glu Ile Thr Ile Thr Ser 
            340                 345                 350         


Ser Ile Asn Ser Ile Leu Glu Asn Ser Pro Pro Gly Thr Val Ile Ala 
        355                 360                 365             


Leu Leu Asn Val Gln Asp Gln Asp Ser Gly Glu Asn Gly Gln Val Ser 
    370                 375                 380                 


Cys Phe Ile Pro Asn His Leu Pro Phe Lys Leu Glu Lys Thr Tyr Gly 
385                 390                 395                 400 


Asn Tyr Tyr Lys Leu Ile Thr Ser Arg Val Leu Asp Arg Glu Leu Val 
                405                 410                 415     


Gln Ser Tyr Asn Ile Thr Leu Thr Ala Thr Asp Gln Gly Ser Pro Pro 
            420                 425                 430         


Leu Ser Ala Glu Thr His Val Trp Leu Asn Val Ala Asp Asp Asn Asp 
        435                 440                 445             


Asn Pro Pro Val Phe Pro His Ser Ser Tyr Ser Ala Tyr Ile Pro Glu 
    450                 455                 460                 


Asn Asn Pro Arg Gly Ala Ser Ile Phe Ser Val Thr Ala Leu Asp Pro 
465                 470                 475                 480 


Asp Ser Lys Gln Asn Ala Leu Val Thr Tyr Ser Leu Thr Asp Asp Thr 
                485                 490                 495     


Val Gln Gly Val Pro Leu Ser Ser Tyr Val Ser Ile Asn Ser Asn Thr 
            500                 505                 510         


Gly Val Leu Tyr Ala Leu Gln Ser Phe Asp Tyr Glu Gln Phe Arg Asp 
        515                 520                 525             


Leu Glu Leu Arg Val Ile Ala Arg Asp Ser Gly Asp Pro Pro Leu Ser 
    530                 535                 540                 


Ser Asn Val Ser Leu Ser Leu Phe Val Leu Asp Gln Asn Asp Asn Ala 
545                 550                 555                 560 


Pro Glu Ile Leu Tyr Pro Ala Leu Pro Thr Asp Gly Ser Thr Gly Val 
                565                 570                 575     


Glu Leu Ala Pro Arg Ser Ala Glu Pro Gly Tyr Leu Val Thr Lys Val 
            580                 585                 590         


Val Ala Val Asp Lys Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Arg 
        595                 600                 605             


Leu Leu Lys Ala Ser Glu Pro Gly Leu Phe Ala Val Gly Glu His Thr 
    610                 615                 620                 


Gly Glu Gln Ala Pro Pro Asn Thr Asp Trp Arg Phe Ser Gln Ala Gln 
625                 630                 635                 640 


Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly Asp Asp Thr Gly Thr Trp 
                645                 650                 655     


Pro Asn Asn Gln Phe Asp Thr Glu Met Leu Gln Ala Met Ile Leu Ala 
            660                 665                 670         


Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser Thr Leu Gly Gly Gly Ala 
        675                 680                 685             


Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly Pro Gln Phe Thr Leu Gln 
    690                 695                 700                 


His Val Pro Asp Tyr Arg Gln Asn Val Tyr Ile Pro Gly Ser Asn Ala 
705                 710                 715                 720 


Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp Gly Lys Ala Pro Ala Gly 
                725                 730                 735     


Gly Asn Gly Asn Lys Lys Lys Ser Gly Lys Lys Glu Lys Lys 
            740                 745                 750 


<210>  10104
<211>  837
<212>  PRT
<213>  Homo Sapiens

<400>  10104

Met Ala Asn Arg Leu Gln Arg Gly Asp Arg Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Cys Ile Phe Leu Gly Thr Leu Arg Gly Phe Arg Ala Arg Gln Ile 
            20                  25                  30          


Arg Tyr Ser Val Pro Glu Glu Thr Glu Lys Gly Ser Phe Val Gly Asn 
        35                  40                  45              


Ile Ser Lys Asp Leu Gly Leu Glu Pro Arg Glu Leu Ala Lys Arg Gly 
    50                  55                  60                  


Val Arg Ile Val Ser Arg Gly Lys Thr Gln Leu Phe Ala Val Asn Pro 
65                  70                  75                  80  


Arg Ser Gly Ser Leu Ile Thr Ala Gly Arg Ile Asp Arg Glu Glu Leu 
                85                  90                  95      


Cys Glu Thr Val Ser Ser Cys Phe Leu Asn Met Glu Leu Leu Val Glu 
            100                 105                 110         


Asp Thr Leu Lys Ile Tyr Gly Val Glu Val Glu Ile Ile Asp Ile Asn 
        115                 120                 125             


Asp Asn Ala Pro Ser Phe Gln Glu Asp Glu Val Glu Ile Lys Val Ser 
    130                 135                 140                 


Glu His Ala Ile Pro Gly Ala Arg Phe Ala Leu Pro Asn Ala Arg Asp 
145                 150                 155                 160 


Pro Asp Val Gly Val Asn Ser Leu Gln Ser Tyr Gln Leu Ser Pro Asn 
                165                 170                 175     


Asn Tyr Phe Ser Leu Gln Leu Arg Gly Arg Thr Asp Gly Ala Lys Asn 
            180                 185                 190         


Pro Glu Leu Val Leu Glu Gly Ser Leu Asp Arg Glu Lys Glu Ala Ala 
        195                 200                 205             


His Leu Leu Leu Leu Thr Ala Leu Asp Gly Gly Asp Pro Ile Arg Lys 
    210                 215                 220                 


Gly Ala Val Pro Ile Arg Val Val Val Leu Asp Val Asn Asp His Ile 
225                 230                 235                 240 


Pro Met Phe Thr Gln Ser Val Tyr Arg Val Ser Val Pro Glu Asn Ile 
                245                 250                 255     


Ser Ser Gly Thr Arg Val Leu Met Val Asn Ala Thr Asp Pro Asp Glu 
            260                 265                 270         


Gly Ile Asn Gly Glu Val Met Tyr Ser Phe Arg Asn Met Glu Ser Lys 
        275                 280                 285             


Ala Ser Glu Ile Phe Gln Leu Asp Ser Gln Thr Gly Glu Val Gln Val 
    290                 295                 300                 


Arg Gly Ser Leu Asp Phe Glu Lys Tyr Arg Phe Tyr Glu Met Glu Ile 
305                 310                 315                 320 


Gln Gly Gln Asp Gly Gly Gly Leu Phe Thr Thr Thr Thr Met Leu Ile 
                325                 330                 335     


Thr Val Val Asp Val Asn Asp Asn Ala Pro Glu Ile Thr Ile Thr Ser 
            340                 345                 350         


Ser Ile Asn Ser Ile Leu Glu Asn Ser Pro Pro Gly Thr Val Ile Ala 
        355                 360                 365             


Leu Leu Asn Val Gln Asp Gln Asp Ser Gly Glu Asn Gly Gln Val Ser 
    370                 375                 380                 


Cys Phe Ile Pro Asn His Leu Pro Phe Lys Leu Glu Lys Thr Tyr Gly 
385                 390                 395                 400 


Asn Tyr Tyr Lys Leu Ile Thr Ser Arg Val Leu Asp Arg Glu Leu Val 
                405                 410                 415     


Gln Ser Tyr Asn Ile Thr Leu Thr Ala Thr Asp Gln Gly Ser Pro Pro 
            420                 425                 430         


Leu Ser Ala Glu Thr His Val Trp Leu Asn Val Ala Asp Asp Asn Asp 
        435                 440                 445             


Asn Pro Pro Val Phe Pro His Ser Ser Tyr Ser Ala Tyr Ile Pro Glu 
    450                 455                 460                 


Asn Asn Pro Arg Gly Ala Ser Ile Phe Ser Val Thr Ala Leu Asp Pro 
465                 470                 475                 480 


Asp Ser Lys Gln Asn Ala Leu Val Thr Tyr Ser Leu Thr Asp Asp Thr 
                485                 490                 495     


Val Gln Gly Val Pro Leu Ser Ser Tyr Val Ser Ile Asn Ser Asn Thr 
            500                 505                 510         


Gly Val Leu Tyr Ala Leu Gln Ser Phe Asp Tyr Glu Gln Phe Arg Asp 
        515                 520                 525             


Leu Glu Leu Arg Val Ile Ala Arg Asp Ser Gly Asp Pro Pro Leu Ser 
    530                 535                 540                 


Ser Asn Val Ser Leu Ser Leu Phe Val Leu Asp Gln Asn Asp Asn Ala 
545                 550                 555                 560 


Pro Glu Ile Leu Tyr Pro Ala Leu Pro Thr Asp Gly Ser Thr Gly Val 
                565                 570                 575     


Glu Leu Ala Pro Arg Ser Ala Glu Pro Gly Tyr Leu Val Thr Lys Val 
            580                 585                 590         


Val Ala Val Asp Lys Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Arg 
        595                 600                 605             


Leu Leu Lys Ala Ser Glu Pro Gly Leu Phe Ala Val Gly Glu His Thr 
    610                 615                 620                 


Gly Glu Val Arg Thr Ala Arg Ala Leu Leu Asp Arg Asp Ala Leu Lys 
625                 630                 635                 640 


Gln Ser Leu Val Val Ala Val Gln Asp His Gly Gln Pro Pro Leu Ser 
                645                 650                 655     


Ala Thr Val Thr Leu Thr Val Ala Val Ala Asp Ser Ile Pro Glu Val 
            660                 665                 670         


Leu Ala Asp Leu Gly Ser Leu Glu Ser Leu Ala Asn Ser Glu Thr Ser 
        675                 680                 685             


Asp Leu Ser Leu Tyr Leu Val Val Ala Val Ala Ala Val Ser Cys Ile 
    690                 695                 700                 


Phe Leu Val Phe Val Ile Val Leu Leu Ala Leu Arg Leu Trp Arg Trp 
705                 710                 715                 720 


His Lys Ser Arg Leu Leu Gln Ala Ser Glu Gly Gly Leu Ala Gly Met 
                725                 730                 735     


Pro Thr Ser His Phe Val Gly Val Asp Gly Val Gln Ala Phe Leu Gln 
            740                 745                 750         


Thr Tyr Ser His Glu Val Ser Leu Ile Ala Asp Ser Gln Lys Ser His 
        755                 760                 765             


Leu Ile Phe Pro Gln Pro Asn Tyr Gly Asp Thr Leu Ile Ser Gln Glu 
    770                 775                 780                 


Ser Cys Glu Lys Ser Glu Pro Leu Leu Ile Ala Glu Asp Ser Ala Ile 
785                 790                 795                 800 


Ile Leu Gly Lys Cys Asp Pro Thr Ser Asn Gln Val Arg Phe Ile Ser 
                805                 810                 815     


Leu Pro Pro Asn Cys Trp Cys Leu Gly Thr Ser Leu Leu Arg Arg Cys 
            820                 825                 830         


Phe Leu Ser Leu Leu 
        835         


<210>  10105
<211>  198
<212>  PRT
<213>  Homo Sapiens

<400>  10105

Met Leu Thr Cys Leu Val Leu Ser Gly Val Ala Gln Pro Val Ala Phe 
1               5                   10                  15      


Gly Gln Gly Gln Gln Phe Leu Pro Val His Pro Gln Asn Pro Gly Phe 
            20                  25                  30          


Val Gln Asn Pro Ser Gly Ala Leu Pro Lys Ala Tyr Pro Asp Asn His 
        35                  40                  45              


Leu Ser Gln Val Asp Val Asn Glu Leu Phe Ser Lys Leu Leu Lys Thr 
    50                  55                  60                  


Gly Ile Leu Lys Leu Ser Gln Thr Asp Ser Ala Thr Thr Gln Val Ser 
65                  70                  75                  80  


Glu Val Thr Ala Gln Pro Pro Pro Glu Glu Glu Glu Asp Gln Asn Glu 
                85                  90                  95      


Asp Gln Asp Val Pro Asp Leu Thr Asn Phe Thr Val Glu Glu Leu Lys 
            100                 105                 110         


Gln Arg Tyr Asp Ser Val Ile Asn Arg Leu Tyr Thr Gly Ile Gln Cys 
        115                 120                 125             


Tyr Ser Cys Gly Met Arg Phe Thr Thr Ser Gln Thr Asp Val Tyr Ala 
    130                 135                 140                 


Asp His Leu Asp Trp His Tyr Arg Gln Asn Arg Thr Glu Lys Asp Val 
145                 150                 155                 160 


Ser Arg Lys Val Thr His Arg Arg Trp Tyr Tyr Ser Leu Thr Asp Trp 
                165                 170                 175     


Ile Glu Phe Glu Glu Ile Ala Asp Leu Glu Glu Arg Ala Lys Ser Gln 
            180                 185                 190         


Phe Phe Glu Lys Val His 
        195             


<210>  10106
<211>  1555
<212>  PRT
<213>  Homo Sapiens

<400>  10106

Met Ser Glu Gln Thr Pro Ala Glu Ala Gly Ala Ala Gly Ala Arg Glu 
1               5                   10                  15      


Asp Ala Cys Arg Asp Tyr Gln Ser Ser Leu Glu Asp Leu Thr Phe Asn 
            20                  25                  30          


Ser Lys Pro His Ile Asn Met Leu Thr Ile Leu Ala Glu Glu Asn Leu 
        35                  40                  45              


Pro Phe Ala Lys Glu Ile Val Ser Leu Ile Glu Ala Gln Thr Ala Lys 
    50                  55                  60                  


Ala Pro Ser Ser Glu Lys Leu Pro Val Met Tyr Leu Met Asp Ser Ile 
65                  70                  75                  80  


Val Lys Asn Val Gly Arg Glu Tyr Leu Thr Ala Phe Thr Lys Asn Leu 
                85                  90                  95      


Val Ala Thr Phe Ile Cys Val Phe Glu Lys Val Asp Glu Asn Thr Arg 
            100                 105                 110         


Lys Ser Leu Phe Lys Leu Arg Ser Thr Trp Asp Glu Ile Phe Pro Leu 
        115                 120                 125             


Lys Lys Leu Tyr Ala Leu Asp Val Arg Val Asn Ser Leu Asp Pro Ala 
    130                 135                 140                 


Trp Pro Ile Lys Pro Leu Pro Pro Asn Val Asn Thr Ser Ser Ile His 
145                 150                 155                 160 


Val Asn Pro Lys Phe Leu Asn Lys Ser Pro Glu Glu Pro Ser Thr Pro 
                165                 170                 175     


Gly Thr Val Val Ser Ser Pro Ser Ile Ser Thr Pro Pro Ile Val Pro 
            180                 185                 190         


Asp Ile Gln Lys Asn Leu Thr Gln Glu Gln Leu Ile Arg Gln Gln Leu 
        195                 200                 205             


Leu Ala Lys Gln Lys Gln Leu Leu Glu Leu Gln Gln Lys Lys Leu Glu 
    210                 215                 220                 


Leu Glu Leu Glu Gln Ala Lys Ala Gln Leu Ala Val Ser Leu Ser Val 
225                 230                 235                 240 


Gln Gln Glu Thr Ser Asn Leu Gly Pro Gly Ser Ala Pro Ser Lys Leu 
                245                 250                 255     


His Val Ser Gln Ile Pro Pro Met Ala Val Lys Ala Pro His Gln Val 
            260                 265                 270         


Pro Val Gln Ser Glu Lys Ser Arg Pro Gly Pro Ser Leu Gln Ile Gln 
        275                 280                 285             


Asp Leu Lys Gly Thr Asn Arg Asp Pro Arg Leu Asn Arg Ile Ser Gln 
    290                 295                 300                 


His Ser His Gly Lys Asp Gln Ser His Arg Lys Glu Phe Leu Met Asn 
305                 310                 315                 320 


Thr Leu Asn Gln Ser Asp Thr Lys Thr Ser Lys Thr Ile Pro Ser Glu 
                325                 330                 335     


Lys Leu Asn Ser Ser Lys Gln Glu Lys Ser Lys Ser Gly Glu Lys Ile 
            340                 345                 350         


Thr Lys Lys Glu Leu Asp Gln Leu Asp Ser Lys Ser Lys Ser Lys Ser 
        355                 360                 365             


Lys Ser Pro Ser Pro Leu Lys Asn Lys Leu Ser His Thr Lys Asp Leu 
    370                 375                 380                 


Lys Asn Gln Glu Ser Glu Ser Met Arg Leu Ser Asp Met Asn Lys Arg 
385                 390                 395                 400 


Asp Pro Arg Leu Lys Lys His Leu Gln Asp Lys Thr Asp Gly Lys Asp 
                405                 410                 415     


Asp Asp Val Lys Glu Lys Arg Lys Thr Ala Glu Lys Lys Asp Lys Asp 
            420                 425                 430         


Glu His Met Lys Ser Ser Glu His Arg Leu Ala Gly Ser Arg Asn Lys 
        435                 440                 445             


Ile Ile Asn Gly Ile Val Gln Lys Gln Asp Thr Ile Thr Glu Glu Ser 
    450                 455                 460                 


Glu Lys Gln Gly Thr Lys Pro Gly Arg Ser Ser Thr Arg Lys Arg Ser 
465                 470                 475                 480 


Arg Ser Arg Ser Pro Lys Ser Arg Ser Pro Ile Ile His Ser Pro Lys 
                485                 490                 495     


Arg Arg Asp Arg Arg Ser Pro Lys Arg Arg Gln Arg Ser Met Ser Pro 
            500                 505                 510         


Thr Ser Thr Pro Lys Ala Gly Lys Ile Arg Gln Ser Gly Ala Lys Gln 
        515                 520                 525             


Ser His Met Glu Glu Phe Thr Pro Pro Ser Arg Glu Asp Arg Asn Ala 
    530                 535                 540                 


Lys Arg Ser Thr Lys Gln Asp Ile Arg Asp Pro Arg Arg Met Lys Lys 
545                 550                 555                 560 


Thr Glu Glu Glu Arg Pro Gln Glu Thr Thr Asn Gln His Ser Thr Lys 
                565                 570                 575     


Ser Gly Thr Glu Pro Lys Glu Asn Val Glu Asn Trp Gln Ser Ser Lys 
            580                 585                 590         


Ser Ala Lys Arg Trp Lys Ser Gly Trp Glu Glu Asn Lys Ser Leu Gln 
        595                 600                 605             


Gln Val Asp Glu His Ser Lys Pro Pro His Leu Arg His Arg Glu Ser 
    610                 615                 620                 


Trp Ser Ser Thr Lys Gly Ile Leu Ser Pro Arg Ala Pro Lys Gln Gln 
625                 630                 635                 640 


Gln His Arg Leu Ser Val Asp Ala Asn Leu Gln Ile Pro Lys Glu Leu 
                645                 650                 655     


Thr Leu Ala Ser Lys Arg Glu Leu Leu Gln Lys Thr Ser Glu Arg Leu 
            660                 665                 670         


Ala Ser Gly Glu Ile Thr Gln Asp Asp Phe Leu Val Val Val His Gln 
        675                 680                 685             


Ile Arg Gln Leu Phe Gln Tyr Gln Glu Gly Val Arg Glu Glu Gln Arg 
    690                 695                 700                 


Ser Pro Phe Asn Asp Arg Phe Pro Leu Lys Arg Pro Arg Tyr Glu Asp 
705                 710                 715                 720 


Ser Asp Lys Pro Phe Val Asp Ser Pro Ala Ser Arg Phe Ala Gly Leu 
                725                 730                 735     


Asp Thr Asn Gln Arg Leu Thr Ala Leu Ala Glu Asp Arg Pro Leu Phe 
            740                 745                 750         


Asp Gly Pro Ser Arg Pro Ser Val Ala Arg Asp Gly Pro Thr Lys Met 
        755                 760                 765             


Ile Phe Glu Gly Pro Asn Lys Leu Ser Pro Arg Ile Asp Gly Pro Pro 
    770                 775                 780                 


Thr Pro Ala Ser Leu Arg Phe Asp Gly Ser Pro Gly Gln Met Gly Gly 
785                 790                 795                 800 


Gly Gly Pro Leu Arg Phe Glu Gly Pro Gln Gly Gln Leu Gly Gly Gly 
                805                 810                 815     


Cys Pro Leu Arg Phe Glu Gly Pro Pro Gly Pro Val Gly Thr Pro Leu 
            820                 825                 830         


Arg Phe Glu Gly Pro Ile Gly Gln Ala Gly Gly Gly Gly Phe Arg Phe 
        835                 840                 845             


Glu Gly Ser Pro Gly Leu Arg Phe Glu Gly Ser Pro Gly Gly Leu Arg 
    850                 855                 860                 


Phe Glu Gly Pro Gly Gly Gln Pro Val Gly Gly Leu Arg Phe Glu Gly 
865                 870                 875                 880 


His Arg Gly Gln Pro Val Gly Gly Leu Arg Phe Glu Gly Pro His Gly 
                885                 890                 895     


Gln Pro Val Gly Gly Leu Arg Phe Asp Asn Pro Arg Gly Gln Pro Val 
            900                 905                 910         


Gly Gly Leu Arg Phe Glu Gly Gly His Gly Pro Ser Gly Ala Ala Ile 
        915                 920                 925             


Arg Phe Asp Gly Pro His Gly Gln Pro Gly Gly Gly Ile Arg Phe Glu 
    930                 935                 940                 


Gly Pro Leu Leu Gln Gln Gly Val Gly Met Arg Phe Glu Gly Pro His 
945                 950                 955                 960 


Gly Gln Ser Val Ala Gly Leu Arg Phe Glu Gly Gln His Asn Gln Leu 
                965                 970                 975     


Gly Gly Asn Leu Arg Phe Glu Gly Pro His Gly Gln Pro Gly Val Gly 
            980                 985                 990         


Ile Arg Phe Glu Gly Pro Leu Val  Gln Gln Gly Gly Gly  Met Arg Phe 
        995                 1000                 1005             


Glu Gly  Pro Ser Val Pro Gly  Gly Gly Leu Arg Ile  Glu Gly Pro 
    1010                 1015                 1020             


Leu Gly  Gln Gly Gly Pro Arg  Phe Glu Gly Cys His  Ala Leu Arg 
    1025                 1030                 1035             


Phe Asp  Gly Gln Pro Gly Gln  Pro Ser Leu Leu Pro  Arg Phe Asp 
    1040                 1045                 1050             


Gly Leu  His Gly Gln Pro Gly  Pro Arg Phe Glu Arg  Thr Pro Gly 
    1055                 1060                 1065             


Gln Pro  Gly Pro Gln Arg Phe  Asp Gly Pro Pro Gly  Gln Gln Val 
    1070                 1075                 1080             


Gln Pro  Arg Phe Asp Gly Val  Pro Gln Arg Phe Asp  Gly Pro Gln 
    1085                 1090                 1095             


His Gln  Gln Ala Ser Arg Phe  Asp Ile Pro Leu Gly  Leu Gln Gly 
    1100                 1105                 1110             


Thr Arg  Phe Asp Asn His Pro  Ser Gln Arg Leu Glu  Ser Val Ser 
    1115                 1120                 1125             


Phe Asn  Gln Thr Gly Pro Tyr  Asn Asp Pro Pro Gly  Asn Ala Phe 
    1130                 1135                 1140             


Asn Ala  Pro Ser Gln Gly Leu  Gln Phe Gln Arg His  Glu Gln Ile 
    1145                 1150                 1155             


Phe Asp  Ser Pro Gln Gly Pro  Asn Phe Asn Gly Pro  His Gly Pro 
    1160                 1165                 1170             


Gly Asn  Gln Ser Phe Ser Asn  Pro Leu Asn Arg Ala  Ser Gly His 
    1175                 1180                 1185             


Tyr Phe  Asp Glu Lys Asn Leu  Gln Ser Ser Gln Phe  Gly Asn Phe 
    1190                 1195                 1200             


Gly Asn  Ile Pro Ala Pro Met  Thr Val Gly Asn Ile  Gln Ala Ser 
    1205                 1210                 1215             


Gln Gln  Val Leu Ser Gly Val  Ala Gln Pro Val Ala  Phe Gly Gln 
    1220                 1225                 1230             


Gly Gln  Gln Phe Leu Pro Val  His Pro Gln Asn Pro  Gly Phe Val 
    1235                 1240                 1245             


Gln Asn  Pro Ser Gly Ala Leu  Pro Lys Ala Tyr Pro  Asp Asn His 
    1250                 1255                 1260             


Leu Ser  Gln Val Asp Val Asn  Glu Leu Phe Ser Lys  Leu Leu Lys 
    1265                 1270                 1275             


Thr Gly  Ile Leu Lys Leu Ser  Gln Thr Asp Ser Ala  Thr Thr Gln 
    1280                 1285                 1290             


Val Ser  Glu Val Thr Ala Gln  Pro Pro Pro Glu Glu  Glu Glu Asp 
    1295                 1300                 1305             


Gln Asn  Glu Asp Gln Asp Val  Pro Asp Leu Thr Asn  Phe Thr Val 
    1310                 1315                 1320             


Glu Glu  Leu Lys Gln Arg Tyr  Asp Ser Val Ile Asn  Arg Leu Tyr 
    1325                 1330                 1335             


Thr Gly  Ile Gln Cys Tyr Ser  Cys Gly Met Arg Phe  Thr Thr Ser 
    1340                 1345                 1350             


Gln Thr  Asp Val Tyr Ala Asp  His Leu Asp Trp His  Tyr Arg Gln 
    1355                 1360                 1365             


Asn Arg  Thr Glu Lys Asp Val  Ser Arg Lys Val Thr  His Arg Arg 
    1370                 1375                 1380             


Trp Tyr  Tyr Ser Leu Thr Asp  Trp Ile Glu Phe Glu  Glu Ile Ala 
    1385                 1390                 1395             


Asp Leu  Glu Glu Arg Ala Lys  Ser Gln Phe Phe Glu  Lys Val His 
    1400                 1405                 1410             


Glu Glu  Val Val Leu Lys Thr  Gln Glu Ala Ala Lys  Glu Lys Glu 
    1415                 1420                 1425             


Phe Gln  Ser Val Pro Ala Gly  Pro Ala Gly Ala Val  Glu Ser Cys 
    1430                 1435                 1440             


Glu Ile  Cys Gln Glu Gln Phe  Glu Gln Tyr Trp Asp  Glu Glu Glu 
    1445                 1450                 1455             


Glu Glu  Trp His Leu Lys Asn  Ala Ile Arg Val Asp  Gly Lys Ile 
    1460                 1465                 1470             


Tyr His  Pro Ser Cys Tyr Glu  Asp Tyr Gln Asn Thr  Ser Ser Phe 
    1475                 1480                 1485             


Asp Cys  Thr Pro Ser Pro Ser  Lys Thr Pro Val Glu  Asn Pro Leu 
    1490                 1495                 1500             


Asn Ile  Met Leu Asn Ile Val  Lys Asn Glu Leu Gln  Glu Pro Cys 
    1505                 1510                 1515             


Asp Ser  Pro Lys Val Lys Glu  Glu Arg Ile Asp Thr  Pro Pro Ala 
    1520                 1525                 1530             


Cys Thr  Glu Glu Ser Ile Ala  Thr Pro Ser Glu Ile  Lys Thr Glu 
    1535                 1540                 1545             


Asn Asp  Thr Val Glu Ser Val  
    1550                 1555 


<210>  10107
<211>  999
<212>  PRT
<213>  Homo Sapiens

<400>  10107

Met Ser Glu Gln Thr Pro Ala Glu Ala Gly Ala Ala Gly Ala Arg Glu 
1               5                   10                  15      


Asp Ala Cys Arg Asp Tyr Gln Ser Ser Leu Glu Asp Leu Thr Phe Asn 
            20                  25                  30          


Ser Lys Pro His Ile Asn Met Leu Thr Ile Leu Ala Glu Glu Asn Leu 
        35                  40                  45              


Pro Phe Ala Lys Glu Ile Val Ser Leu Ile Glu Ala Gln Thr Ala Lys 
    50                  55                  60                  


Ala Pro Ser Ser Glu Lys Leu Pro Val Met Tyr Leu Met Asp Ser Ile 
65                  70                  75                  80  


Val Lys Asn Val Gly Arg Glu Tyr Leu Thr Ala Phe Thr Lys Asn Leu 
                85                  90                  95      


Val Ala Thr Phe Ile Cys Val Phe Glu Lys Val Asp Glu Asn Thr Arg 
            100                 105                 110         


Lys Ser Leu Phe Lys Leu Arg Ser Thr Trp Asp Glu Ile Phe Pro Leu 
        115                 120                 125             


Lys Lys Leu Tyr Ala Leu Asp Val Arg Val Asn Ser Leu Asp Pro Ala 
    130                 135                 140                 


Trp Pro Ile Lys Pro Leu Pro Pro Asn Val Asn Thr Ser Ser Ile His 
145                 150                 155                 160 


Val Asn Pro Lys Phe Leu Asn Lys Ser Pro Glu Glu Pro Ser Thr Pro 
                165                 170                 175     


Gly Thr Val Val Ser Ser Pro Ser Ile Ser Thr Pro Pro Ile Val Pro 
            180                 185                 190         


Asp Ile Gln Lys Asn Leu Thr Gln Glu Gln Leu Ile Arg Gln Gln Leu 
        195                 200                 205             


Leu Ala Lys Gln Lys Gln Leu Leu Glu Leu Gln Gln Lys Lys Leu Glu 
    210                 215                 220                 


Leu Glu Leu Glu Gln Ala Lys Ala Gln Leu Ala Val Ser Leu Ser Val 
225                 230                 235                 240 


Gln Gln Glu Thr Ser Asn Leu Gly Pro Gly Ser Ala Pro Ser Lys Leu 
                245                 250                 255     


His Val Ser Gln Ile Pro Pro Met Ala Val Lys Ala Pro His Gln Val 
            260                 265                 270         


Pro Val Gln Ser Glu Lys Ser Arg Pro Gly Pro Ser Leu Gln Ile Gln 
        275                 280                 285             


Asp Leu Lys Gly Thr Asn Arg Asp Pro Arg Leu Asn Arg Ile Ser Gln 
    290                 295                 300                 


His Ser His Gly Lys Asp Gln Ser His Arg Lys Glu Phe Leu Met Asn 
305                 310                 315                 320 


Thr Leu Asn Gln Ser Asp Thr Lys Thr Ser Lys Thr Ile Pro Ser Glu 
                325                 330                 335     


Lys Leu Asn Ser Ser Lys Gln Glu Lys Ser Lys Ser Gly Glu Lys Ile 
            340                 345                 350         


Thr Lys Lys Glu Leu Asp Gln Leu Asp Ser Lys Ser Lys Ser Lys Ser 
        355                 360                 365             


Lys Ser Pro Ser Pro Leu Lys Asn Lys Leu Ser His Thr Lys Asp Leu 
    370                 375                 380                 


Lys Asn Gln Glu Ser Glu Ser Met Arg Leu Ser Asp Met Asn Lys Arg 
385                 390                 395                 400 


Asp Pro Arg Leu Lys Lys His Leu Gln Asp Lys Thr Asp Gly Lys Asp 
                405                 410                 415     


Asp Asp Val Lys Glu Lys Arg Lys Thr Ala Glu Lys Lys Asp Lys Asp 
            420                 425                 430         


Glu His Met Lys Ser Ser Glu His Arg Leu Ala Gly Ser Arg Asn Lys 
        435                 440                 445             


Ile Ile Asn Gly Ile Val Gln Lys Gln Asp Thr Ile Thr Glu Glu Ser 
    450                 455                 460                 


Glu Lys Gln Gly Thr Lys Pro Gly Arg Ser Ser Thr Arg Lys Arg Ser 
465                 470                 475                 480 


Arg Ser Arg Ser Pro Lys Ser Arg Ser Pro Ile Ile His Ser Pro Lys 
                485                 490                 495     


Arg Arg Asp Arg Arg Ser Pro Lys Arg Arg Gln Arg Ser Met Ser Pro 
            500                 505                 510         


Thr Ser Thr Pro Lys Ala Gly Lys Ile Arg Gln Ser Gly Ala Lys Gln 
        515                 520                 525             


Ser His Met Glu Glu Phe Thr Pro Pro Ser Arg Glu Asp Arg Asn Ala 
    530                 535                 540                 


Lys Arg Ser Thr Lys Gln Asp Ile Arg Asp Pro Arg Arg Met Lys Lys 
545                 550                 555                 560 


Thr Glu Glu Glu Arg Pro Gln Glu Thr Thr Asn Gln His Ser Thr Lys 
                565                 570                 575     


Ser Gly Thr Glu Pro Lys Glu Asn Val Glu Asn Trp Gln Ser Ser Lys 
            580                 585                 590         


Ser Ala Lys Arg Trp Lys Ser Gly Trp Glu Glu Asn Lys Ser Leu Gln 
        595                 600                 605             


Gln Val Asp Glu His Ser Lys Pro Pro His Leu Arg His Arg Glu Ser 
    610                 615                 620                 


Trp Ser Ser Thr Lys Gly Ile Leu Ser Pro Arg Ala Pro Lys Gln Gln 
625                 630                 635                 640 


Gln His Arg Leu Ser Val Asp Ala Asn Leu Gln Ile Pro Lys Glu Leu 
                645                 650                 655     


Thr Leu Ala Ser Lys Arg Glu Leu Leu Gln Lys Thr Ser Glu Arg Leu 
            660                 665                 670         


Ala Ser Gly Glu Ile Thr Gln Asp Asp Phe Leu Val Val Val His Gln 
        675                 680                 685             


Ile Arg Gln Leu Phe Gln Tyr Gln Glu Gly Lys His Arg Cys Asn Val 
    690                 695                 700                 


Arg Asp Ser Pro Thr Glu Glu Asn Lys Gly Gly Leu Lys Lys Lys Pro 
705                 710                 715                 720 


Leu Leu Ser Asp Ala Glu Leu Thr Tyr Tyr Glu His Lys Ala Lys Leu 
                725                 730                 735     


Lys Arg Thr Gln Val Gln His Ser Phe Pro Arg Leu Asp Leu Leu Asp 
            740                 745                 750         


Pro Asp Ile Phe Asp Tyr Pro Leu Thr Asp Ala Leu Leu Ser Gly Ile 
        755                 760                 765             


Glu Cys Glu Pro Ser Lys Ser Lys His Ala Ser Arg Asn Ser Gly Ala 
    770                 775                 780                 


Gln Phe Asp Arg Lys Glu Gln Phe Ser Glu Arg Ala Arg Arg Leu Ser 
785                 790                 795                 800 


Pro Ile Ser Gly Ser Arg Thr Tyr Ala Glu Asn Leu Ser Pro His Glu 
                805                 810                 815     


Gly Arg Arg Arg His Asp Glu Gln Val Ser Ala Lys Gly Val Arg Glu 
            820                 825                 830         


Glu Gln Arg Ser Pro Phe Asn Asp Arg Phe Pro Leu Lys Arg Pro Arg 
        835                 840                 845             


Tyr Glu Asp Ser Asp Lys Pro Phe Val Asp Ser Pro Ala Ser Arg Phe 
    850                 855                 860                 


Ala Gly Leu Asp Thr Asn Gln Arg Leu Thr Ala Leu Ala Glu Asp Arg 
865                 870                 875                 880 


Pro Leu Phe Asp Gly Pro Ser Arg Pro Ser Val Ala Arg Asp Gly Pro 
                885                 890                 895     


Thr Lys Met Ile Phe Glu Gly Pro Asn Lys Leu Ser Pro Arg Ile Asp 
            900                 905                 910         


Gly Pro Pro Thr Pro Ala Ser Leu Arg Phe Asp Gly Ser Pro Gly Gln 
        915                 920                 925             


Met Gly Gly Gly Gly Pro Leu Arg Phe Glu Gly Pro Gln Gly Gln Leu 
    930                 935                 940                 


Gly Gly Gly Cys Pro Leu Arg Phe Glu Gly Pro Pro Gly Pro Val Gly 
945                 950                 955                 960 


Thr Pro Leu Arg Phe Glu Gly Pro Ile Gly Gln Ala Gly Gly Gly Gly 
                965                 970                 975     


Phe Arg Phe Glu Gly Ser Pro Gly Leu Arg Phe Glu Gly Ser Pro Gly 
            980                 985                 990         


Gly Leu Arg Phe Glu Gly Pro 
        995                 


<210>  10108
<211>  784
<212>  PRT
<213>  Homo Sapiens

<400>  10108

Met Ser Glu Gln Thr Pro Ala Glu Ala Gly Ala Ala Gly Ala Arg Glu 
1               5                   10                  15      


Asp Ala Cys Arg Asp Tyr Gln Ser Ser Leu Glu Asp Leu Thr Phe Asn 
            20                  25                  30          


Ser Lys Pro His Ile Asn Met Leu Thr Ile Leu Ala Glu Glu Asn Leu 
        35                  40                  45              


Pro Phe Ala Lys Glu Ile Val Ser Leu Ile Glu Ala Gln Thr Ala Lys 
    50                  55                  60                  


Ala Pro Ser Ser Glu Lys Leu Pro Val Met Tyr Leu Met Asp Ser Ile 
65                  70                  75                  80  


Val Lys Asn Val Gly Arg Glu Tyr Leu Thr Ala Phe Thr Lys Asn Leu 
                85                  90                  95      


Val Ala Thr Phe Ile Cys Val Phe Glu Lys Val Asp Glu Asn Thr Arg 
            100                 105                 110         


Lys Ser Leu Phe Lys Leu Arg Ser Thr Trp Asp Glu Ile Phe Pro Leu 
        115                 120                 125             


Lys Lys Leu Tyr Ala Leu Asp Val Arg Val Asn Ser Leu Asp Pro Ala 
    130                 135                 140                 


Trp Pro Ile Lys Pro Leu Pro Pro Asn Val Asn Thr Ser Ser Ile His 
145                 150                 155                 160 


Val Asn Pro Lys Phe Leu Asn Lys Ser Pro Glu Glu Pro Ser Thr Pro 
                165                 170                 175     


Gly Thr Val Val Ser Ser Pro Ser Ile Ser Thr Pro Pro Ile Val Pro 
            180                 185                 190         


Asp Ile Gln Lys Asn Leu Thr Gln Glu Gln Leu Ile Arg Gln Gln Leu 
        195                 200                 205             


Leu Ala Lys Gln Lys Gln Leu Leu Glu Leu Gln Gln Lys Lys Leu Glu 
    210                 215                 220                 


Leu Glu Leu Glu Gln Ala Lys Ala Gln Leu Ala Val Ser Leu Ser Val 
225                 230                 235                 240 


Gln Gln Glu Thr Ser Asn Leu Gly Pro Gly Ser Ala Pro Ser Lys Leu 
                245                 250                 255     


His Val Ser Gln Ile Pro Pro Met Ala Val Lys Ala Pro His Gln Val 
            260                 265                 270         


Pro Val Gln Ser Glu Lys Ser Arg Pro Gly Pro Ser Leu Gln Ile Gln 
        275                 280                 285             


Asp Leu Lys Gly Thr Asn Arg Asp Pro Arg Leu Asn Arg Ile Ser Gln 
    290                 295                 300                 


His Ser His Gly Lys Asp Gln Ser His Arg Lys Glu Phe Leu Met Asn 
305                 310                 315                 320 


Thr Leu Asn Gln Ser Asp Thr Lys Thr Ser Lys Thr Ile Pro Ser Glu 
                325                 330                 335     


Lys Leu Asn Ser Ser Lys Gln Glu Lys Ser Lys Ser Gly Glu Lys Ile 
            340                 345                 350         


Thr Lys Lys Glu Leu Asp Gln Leu Asp Ser Lys Ser Lys Ser Lys Ser 
        355                 360                 365             


Lys Ser Pro Ser Pro Leu Lys Asn Lys Leu Ser His Thr Lys Asp Leu 
    370                 375                 380                 


Lys Asn Gln Glu Ser Glu Ser Met Arg Leu Ser Asp Met Asn Lys Arg 
385                 390                 395                 400 


Asp Pro Arg Leu Lys Lys His Leu Gln Asp Lys Thr Asp Gly Lys Asp 
                405                 410                 415     


Asp Asp Val Lys Glu Lys Arg Lys Thr Ala Glu Lys Lys Asp Lys Asp 
            420                 425                 430         


Glu His Met Lys Ser Ser Glu His Arg Leu Ala Gly Ser Arg Asn Lys 
        435                 440                 445             


Ile Ile Asn Gly Ile Val Gln Lys Gln Asp Thr Ile Thr Glu Glu Ser 
    450                 455                 460                 


Glu Lys Gln Gly Thr Lys Pro Gly Arg Ser Ser Thr Arg Lys Arg Ser 
465                 470                 475                 480 


Arg Ser Arg Ser Pro Lys Ser Arg Ser Pro Ile Ile His Ser Pro Lys 
                485                 490                 495     


Arg Arg Asp Arg Arg Ser Pro Lys Arg Arg Gln Arg Ser Met Ser Pro 
            500                 505                 510         


Thr Ser Thr Pro Lys Ala Gly Lys Ile Arg Gln Ser Gly Ala Lys Gln 
        515                 520                 525             


Ser His Met Glu Glu Phe Thr Pro Pro Ser Arg Glu Asp Arg Asn Ala 
    530                 535                 540                 


Lys Arg Ser Thr Lys Gln Asp Ile Arg Asp Pro Arg Arg Met Lys Lys 
545                 550                 555                 560 


Thr Glu Glu Glu Arg Pro Gln Glu Thr Thr Asn Gln His Ser Thr Lys 
                565                 570                 575     


Ser Gly Thr Glu Pro Lys Glu Asn Val Glu Asn Trp Gln Ser Ser Lys 
            580                 585                 590         


Ser Ala Lys Arg Trp Lys Ser Gly Trp Glu Glu Asn Lys Ser Leu Gln 
        595                 600                 605             


Gln Val Asp Glu His Ser Lys Pro Pro His Leu Arg His Arg Glu Ser 
    610                 615                 620                 


Trp Ser Ser Thr Lys Gly Ile Leu Ser Pro Arg Ala Pro Lys Gln Gln 
625                 630                 635                 640 


Gln His Arg Leu Ser Val Asp Ala Asn Leu Gln Ile Pro Lys Glu Leu 
                645                 650                 655     


Thr Leu Ala Ser Lys Arg Glu Leu Leu Gln Lys Thr Ser Glu Arg Leu 
            660                 665                 670         


Ala Ser Gly Glu Ile Thr Gln Asp Asp Phe Leu Val Val Val His Gln 
        675                 680                 685             


Ile Arg Gln Leu Phe Gln Tyr Gln Glu Gly Val Arg Glu Glu Gln Arg 
    690                 695                 700                 


Ser Pro Phe Asn Asp Arg Phe Pro Leu Lys Arg Pro Arg Tyr Glu Asp 
705                 710                 715                 720 


Ser Asp Lys Pro Phe Val Asp Ser Pro Ala Ser Arg Phe Ala Gly Leu 
                725                 730                 735     


Asp Thr Asn Gln Arg Leu Thr Ala Leu Ala Glu Asp Arg Pro Leu Phe 
            740                 745                 750         


Asp Gly Pro Ser Arg Pro Ser Val Ala Arg Asp Gly Pro Thr Lys Met 
        755                 760                 765             


Ile Phe Glu Gly Pro Asn Lys Leu Ser Pro Arg Ile Asp Gly Pro Pro 
    770                 775                 780                 


<210>  10109
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  10109

Met Ser Glu Gln Thr Pro Ala Glu Ala Gly Ala Ala Gly Ala Arg Glu 
1               5                   10                  15      


Asp Ala Cys Arg Asp Tyr Gln Ser Ser Leu Glu Asp Leu Thr Phe Asn 
            20                  25                  30          


Ser Lys Pro His Ile Asn Met Leu Thr Ile Leu Ala Glu Glu Asn Leu 
        35                  40                  45              


Pro Phe Ala Lys Glu Ile Val Ser Leu Ile Glu Ala Gln Thr Ala Lys 
    50                  55                  60                  


Val Asp Glu Asn Thr Arg Lys Ser Leu Phe Lys Leu Arg Ser Thr Trp 
65                  70                  75                  80  


Asp Glu Ile Phe Pro Leu Lys Lys Leu Tyr Ala Leu Asp Val Arg Val 
                85                  90                  95      


Asn Ser Leu 
            


<210>  10110
<211>  449
<212>  PRT
<213>  Homo Sapiens

<400>  10110

Met Leu Pro Ala Ala Thr Ala Ser Leu Leu Gly Pro Leu Leu Thr Ala 
1               5                   10                  15      


Cys Ala Leu Leu Pro Phe Ala Gln Gly Gln Thr Pro Asn Tyr Thr Arg 
            20                  25                  30          


Pro Val Phe Leu Cys Gly Gly Asp Val Lys Gly Glu Ser Gly Tyr Val 
        35                  40                  45              


Ala Ser Glu Gly Phe Pro Asn Leu Tyr Pro Pro Asn Lys Glu Cys Ile 
    50                  55                  60                  


Trp Thr Ile Thr Val Pro Glu Gly Gln Thr Val Ser Leu Ser Phe Arg 
65                  70                  75                  80  


Val Phe Asp Leu Glu Leu His Pro Ala Cys Arg Tyr Asp Ala Leu Glu 
                85                  90                  95      


Val Phe Ala Gly Ser Gly Thr Ser Gly Gln Arg Leu Gly Arg Phe Cys 
            100                 105                 110         


Gly Thr Phe Arg Pro Ala Pro Leu Val Ala Pro Gly Asn Gln Val Thr 
        115                 120                 125             


Leu Arg Met Thr Thr Asp Glu Gly Thr Gly Gly Arg Gly Phe Leu Leu 
    130                 135                 140                 


Trp Tyr Ser Gly Arg Ala Thr Ser Gly Thr Glu His Gln Phe Cys Gly 
145                 150                 155                 160 


Gly Arg Leu Glu Lys Ala Gln Gly Thr Leu Thr Thr Pro Asn Trp Pro 
                165                 170                 175     


Glu Ser Asp Tyr Pro Pro Gly Ile Ser Cys Ser Trp His Ile Ile Ala 
            180                 185                 190         


Pro Pro Asp Gln Val Ile Ala Leu Thr Phe Glu Lys Phe Asp Leu Glu 
        195                 200                 205             


Pro Asp Thr Tyr Cys Arg Tyr Asp Ser Val Ser Val Phe Asn Gly Ala 
    210                 215                 220                 


Val Ser Asp Asp Ser Arg Arg Leu Gly Lys Phe Cys Gly Asp Ala Val 
225                 230                 235                 240 


Pro Gly Ser Ile Ser Ser Glu Gly Asn Glu Leu Leu Val Gln Phe Val 
                245                 250                 255     


Ser Asp Leu Ser Val Thr Ala Asp Gly Phe Ser Ala Ser Tyr Lys Thr 
            260                 265                 270         


Leu Pro Arg Gly Thr Ala Lys Glu Gly Gln Gly Pro Gly Pro Lys Arg 
        275                 280                 285             


Gly Thr Glu Pro Lys Val Lys Leu Pro Pro Lys Ser Gln Pro Pro Glu 
    290                 295                 300                 


Lys Thr Glu Glu Ser Pro Ser Ala Pro Asp Ala Pro Thr Cys Pro Lys 
305                 310                 315                 320 


Gln Cys Arg Arg Thr Gly Thr Leu Gln Ser Asn Phe Cys Ala Ser Ser 
                325                 330                 335     


Leu Val Val Thr Ala Thr Val Lys Ser Met Val Arg Glu Pro Gly Glu 
            340                 345                 350         


Gly Leu Ala Val Thr Val Ser Leu Ile Gly Ala Tyr Lys Thr Gly Gly 
        355                 360                 365             


Leu Asp Leu Pro Ser Pro Pro Thr Gly Ala Ser Leu Lys Phe Tyr Val 
    370                 375                 380                 


Pro Cys Lys Gln Cys Pro Pro Met Lys Lys Gly Val Ser Tyr Leu Leu 
385                 390                 395                 400 


Met Gly Gln Val Glu Glu Asn Arg Gly Pro Val Leu Pro Pro Glu Ser 
                405                 410                 415     


Phe Val Val Leu His Arg Pro Asn Gln Asp Gln Ile Leu Thr Asn Leu 
            420                 425                 430         


Ser Lys Arg Lys Cys Pro Ser Gln Pro Val Arg Ala Ala Ala Ser Gln 
        435                 440                 445             


Asp 
    


<210>  10111
<211>  303
<212>  PRT
<213>  Homo Sapiens

<400>  10111

Met Arg Gly Ala Asn Ala Trp Ala Pro Leu Cys Leu Leu Leu Ala Ala 
1               5                   10                  15      


Ala Thr Gln Leu Ser Arg Gln Gln Ser Pro Glu Arg Pro Val Phe Thr 
            20                  25                  30          


Cys Gly Gly Ile Leu Thr Gly Glu Ser Gly Phe Ile Gly Ser Glu Gly 
        35                  40                  45              


Phe Pro Gly Val Tyr Pro Pro Asn Ser Lys Cys Thr Trp Lys Ile Thr 
    50                  55                  60                  


Val Pro Glu Gly Lys Val Val Val Leu Asn Phe Arg Phe Ile Asp Leu 
65                  70                  75                  80  


Glu Ser Asp Asn Leu Cys Arg Tyr Asp Phe Val Asp Val Tyr Asn Gly 
                85                  90                  95      


His Ala Asn Gly Gln Arg Ile Gly Arg Phe Cys Gly Thr Phe Arg Pro 
            100                 105                 110         


Gly Ala Leu Val Ser Ser Gly Asn Lys Met Met Val Gln Met Ile Ser 
        115                 120                 125             


Asp Ala Asn Thr Ala Gly Asn Gly Phe Met Ala Met Phe Ser Ala Ala 
    130                 135                 140                 


Glu Pro Asn Glu Arg Gly Asp Gln Tyr Cys Gly Gly Leu Leu Asp Arg 
145                 150                 155                 160 


Pro Ser Gly Ser Phe Lys Thr Pro Asn Trp Pro Asp Arg Asp Tyr Pro 
                165                 170                 175     


Ala Gly Val Thr Cys Val Trp His Ile Val Ala Pro Lys Asn Gln Leu 
            180                 185                 190         


Ile Glu Leu Lys Phe Glu Lys Phe Asp Val Glu Arg Asp Asn Tyr Cys 
        195                 200                 205             


Arg Tyr Asp Tyr Val Ala Val Phe Asn Gly Gly Glu Val Asn Asp Ala 
    210                 215                 220                 


Arg Arg Ile Gly Lys Tyr Cys Gly Asp Ser Pro Pro Ala Ile Ser Arg 
225                 230                 235                 240 


His Cys Tyr His Asn His His Ser Arg Trp Glu Phe Ala Arg His Ser 
                245                 250                 255     


Leu Asp His Gln His Leu Gln Arg Gly Lys Phe Gly Asp Ser Ala Gly 
            260                 265                 270         


Gly Gln Glu His Glu Cys Gln Ala Asp Cys Arg Leu Gln Ala Val Pro 
        275                 280                 285             


Ser Pro Gln Lys Arg Ser Lys Leu His Tyr Tyr Gly Pro Ser Arg 
    290                 295                 300             


<210>  10112
<211>  415
<212>  PRT
<213>  Homo Sapiens

<400>  10112

Met Arg Gly Ala Asn Ala Trp Ala Pro Leu Cys Leu Leu Leu Ala Ala 
1               5                   10                  15      


Ala Thr Gln Leu Ser Arg Gln Gln Ser Pro Glu Arg Pro Val Phe Thr 
            20                  25                  30          


Cys Gly Gly Ile Leu Thr Gly Glu Ser Gly Phe Ile Gly Ser Glu Gly 
        35                  40                  45              


Phe Pro Gly Val Tyr Pro Pro Asn Ser Lys Cys Thr Trp Lys Ile Thr 
    50                  55                  60                  


Val Pro Glu Gly Lys Val Val Val Leu Asn Phe Arg Phe Ile Asp Leu 
65                  70                  75                  80  


Glu Ser Asp Asn Leu Cys Arg Tyr Asp Phe Val Asp Val Tyr Asn Gly 
                85                  90                  95      


His Ala Asn Gly Gln Arg Ile Gly Arg Phe Cys Gly Thr Phe Arg Pro 
            100                 105                 110         


Gly Ala Leu Val Ser Ser Gly Asn Lys Met Met Val Gln Met Ile Ser 
        115                 120                 125             


Asp Ala Asn Thr Ala Gly Asn Gly Phe Met Ala Met Phe Ser Ala Ala 
    130                 135                 140                 


Glu Pro Asn Glu Arg Gly Asp Gln Tyr Cys Gly Gly Leu Leu Asp Arg 
145                 150                 155                 160 


Pro Ser Gly Ser Phe Lys Thr Pro Asn Trp Pro Asp Arg Asp Tyr Pro 
                165                 170                 175     


Ala Gly Val Thr Cys Val Trp His Ile Val Ala Pro Lys Asn Gln Leu 
            180                 185                 190         


Ile Glu Leu Lys Phe Glu Lys Phe Asp Val Glu Arg Asp Asn Tyr Cys 
        195                 200                 205             


Arg Tyr Asp Tyr Val Ala Val Phe Asn Gly Gly Glu Val Asn Asp Ala 
    210                 215                 220                 


Arg Arg Ile Gly Lys Tyr Cys Gly Asp Ser Pro Pro Ala Pro Ile Val 
225                 230                 235                 240 


Ser Glu Arg Asn Glu Leu Leu Ile Gln Phe Leu Ser Asp Leu Ser Leu 
                245                 250                 255     


Thr Ala Asp Gly Phe Ile Gly His Tyr Ile Phe Arg Pro Lys Lys Leu 
            260                 265                 270         


Pro Thr Thr Thr Glu Gln Pro Val Thr Thr Thr Phe Pro Val Thr Thr 
        275                 280                 285             


Gly Leu Lys Pro Thr Val Ala Leu Cys Gln Gln Lys Cys Arg Arg Thr 
    290                 295                 300                 


Gly Thr Leu Glu Gly Asn Tyr Cys Ser Ser Asp Phe Val Leu Ala Gly 
305                 310                 315                 320 


Thr Val Ile Thr Thr Ile Thr Arg Asp Gly Ser Leu His Ala Thr Val 
                325                 330                 335     


Ser Ile Ile Asn Ile Tyr Lys Glu Gly Asn Leu Ala Ile Gln Gln Ala 
            340                 345                 350         


Gly Lys Asn Met Ser Ala Arg Leu Thr Val Val Cys Lys Gln Cys Pro 
        355                 360                 365             


Leu Leu Arg Arg Gly Leu Asn Tyr Ile Ile Met Gly Gln Val Gly Glu 
    370                 375                 380                 


Asp Gly Arg Gly Lys Ile Met Pro Asn Ser Phe Ile Met Met Phe Lys 
385                 390                 395                 400 


Thr Lys Asn Gln Lys Leu Leu Asp Ala Leu Lys Asn Lys Gln Cys 
                405                 410                 415 


<210>  10113
<211>  140
<212>  PRT
<213>  Homo Sapiens

<400>  10113

Thr Glu Gln Pro Val Thr Thr Thr Phe Pro Val Thr Thr Gly Leu Lys 
1               5                   10                  15      


Pro Thr Val Ala Leu Cys Gln Gln Lys Cys Arg Arg Thr Gly Thr Leu 
            20                  25                  30          


Glu Gly Asn Tyr Cys Ser Ser Asp Phe Val Leu Ala Gly Thr Val Ile 
        35                  40                  45              


Thr Thr Ile Thr Arg Asp Gly Ser Leu His Ala Thr Val Ser Ile Ile 
    50                  55                  60                  


Asn Ile Tyr Lys Glu Gly Asn Leu Ala Ile Gln Gln Ala Gly Lys Asn 
65                  70                  75                  80  


Met Ser Ala Arg Leu Thr Val Val Cys Lys Gln Cys Pro Leu Leu Arg 
                85                  90                  95      


Arg Gly Leu Asn Tyr Ile Ile Met Gly Gln Val Gly Glu Asp Gly Arg 
            100                 105                 110         


Gly Lys Ile Met Pro Asn Ser Phe Ile Met Met Phe Lys Thr Lys Asn 
        115                 120                 125             


Gln Lys Leu Leu Asp Ala Leu Lys Asn Lys Gln Cys 
    130                 135                 140 


<210>  10114
<211>  101
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  10114

Xaa Gly Thr Phe Arg Pro Gly Ala Leu Val Ser Ser Gly Asn Lys Met 
1               5                   10                  15      


Met Val Gln Met Ile Ser Asp Ala Asn Thr Ala Gly Asn Gly Phe Met 
            20                  25                  30          


Ala Met Phe Ser Ala Ala Glu Pro Asn Glu Arg Gly Lys Lys Lys Lys 
        35                  40                  45              


Arg Gly Pro Glu Ser Thr Ser Pro Leu Ser Arg Val Ala Met Leu Cys 
    50                  55                  60                  


Gln Gly Ile Ser Ile Val Glu Asp Ser Leu Thr Asp Leu Pro Ala Leu 
65                  70                  75                  80  


Leu Lys Pro Pro Thr Gly Gln Thr Gly Ile Thr Leu Gln Glu Ser Leu 
                85                  90                  95      


Val Cys Gly Thr Leu 
            100     


<210>  10115
<211>  158
<212>  PRT
<213>  Homo Sapiens

<400>  10115

Met Glu Arg Arg Ala Trp Ser Leu Gln Cys Thr Ala Phe Val Leu Phe 
1               5                   10                  15      


Cys Ala Trp Cys Ala Leu Asn Ser Ala Lys Ala Lys Arg Gln Phe Val 
            20                  25                  30          


Asn Glu Trp Ala Ala Glu Ile Pro Gly Gly Pro Glu Ala Ala Ser Ala 
        35                  40                  45              


Ile Ala Glu Glu Leu Gly Tyr Asp Leu Leu Gly Gln Ile Gly Ser Leu 
    50                  55                  60                  


Glu Asn His Tyr Leu Phe Lys His Lys Asn His Pro Arg Arg Ser Arg 
65                  70                  75                  80  


Arg Ser Ala Phe His Ile Thr Lys Arg Leu Ser Asp Asp Asp Arg Val 
                85                  90                  95      


Ile Trp Ala Glu Gln Gln Tyr Glu Lys Glu Arg Ser Lys Arg Ser Ala 
            100                 105                 110         


Leu Arg Asp Ser Ala Leu Asn Leu Phe Asn Asp Pro Met Trp Asn Gln 
        115                 120                 125             


Gln Trp Tyr Leu Gln Asp Thr Arg Met Thr Ala Ala Leu Pro Lys Leu 
    130                 135                 140                 


Asp Leu His Val Ile Pro Val Trp Gln Lys Gly Ile Thr Gly 
145                 150                 155             


<210>  10116
<211>  753
<212>  PRT
<213>  Homo Sapiens

<400>  10116

Met Glu Arg Arg Ala Trp Ser Leu Gln Cys Thr Ala Phe Val Leu Phe 
1               5                   10                  15      


Cys Ala Trp Cys Ala Leu Asn Ser Ala Lys Ala Lys Arg Gln Phe Val 
            20                  25                  30          


Asn Glu Trp Ala Ala Glu Ile Pro Gly Gly Pro Glu Ala Ala Ser Ala 
        35                  40                  45              


Ile Ala Glu Glu Leu Gly Tyr Asp Leu Leu Gly Gln Ile Gly Ser Leu 
    50                  55                  60                  


Glu Asn His Tyr Leu Phe Lys His Lys Asn His Pro Arg Arg Ser Arg 
65                  70                  75                  80  


Arg Ser Ala Phe His Ile Thr Lys Arg Leu Ser Asp Asp Asp Arg Val 
                85                  90                  95      


Ile Trp Ala Glu Gln Gln Tyr Glu Lys Glu Arg Ser Lys Arg Ser Ala 
            100                 105                 110         


Leu Arg Asp Ser Ala Leu Asn Leu Phe Asn Asp Pro Met Trp Asn Gln 
        115                 120                 125             


Gln Trp Tyr Leu Gln Asp Thr Arg Met Thr Ala Ala Leu Pro Lys Leu 
    130                 135                 140                 


Asp Leu His Val Ile Pro Val Trp Gln Lys Gly Ile Thr Gly Lys Gly 
145                 150                 155                 160 


Val Val Ile Thr Val Leu Asp Asp Gly Leu Glu Trp Asn His Thr Asp 
                165                 170                 175     


Ile Tyr Ala Asn Tyr Asp Pro Glu Ala Ser Tyr Asp Phe Asn Asp Asn 
            180                 185                 190         


Asp His Asp Pro Phe Pro Arg Tyr Asp Pro Thr Asn Glu Asn Lys His 
        195                 200                 205             


Gly Thr Arg Cys Ala Gly Glu Ile Ala Met Gln Ala Asn Asn His Lys 
    210                 215                 220                 


Cys Gly Val Gly Val Ala Tyr Asn Ser Lys Val Gly Gly Ile Arg Met 
225                 230                 235                 240 


Leu Asp Gly Ile Val Thr Asp Ala Ile Glu Ala Ser Ser Ile Gly Phe 
                245                 250                 255     


Asn Pro Gly His Val Asp Ile Tyr Ser Ala Ser Trp Gly Pro Asn Asp 
            260                 265                 270         


Asp Gly Lys Thr Val Glu Gly Pro Gly Arg Leu Ala Gln Lys Ala Phe 
        275                 280                 285             


Glu Tyr Gly Val Lys Gln Gly Arg Gln Gly Lys Gly Ser Ile Phe Val 
    290                 295                 300                 


Trp Ala Ser Gly Asn Gly Gly Arg Gln Gly Asp Asn Cys Asp Cys Asp 
305                 310                 315                 320 


Gly Tyr Thr Asp Ser Ile Tyr Thr Ile Ser Ile Ser Ser Ala Ser Gln 
                325                 330                 335     


Gln Gly Leu Ser Pro Trp Tyr Ala Glu Lys Cys Ser Ser Thr Leu Ala 
            340                 345                 350         


Thr Ser Tyr Ser Ser Gly Asp Tyr Thr Asp Gln Arg Ile Thr Ser Ala 
        355                 360                 365             


Asp Leu His Asn Asp Cys Thr Glu Thr His Thr Gly Thr Ser Ala Ser 
    370                 375                 380                 


Ala Pro Leu Ala Ala Gly Ile Phe Ala Leu Ala Leu Glu Ala Asn Pro 
385                 390                 395                 400 


Asn Leu Thr Trp Arg Asp Met Gln His Leu Val Val Trp Thr Ser Glu 
                405                 410                 415     


Tyr Asp Pro Leu Ala Asn Asn Pro Gly Trp Lys Lys Asn Gly Ala Gly 
            420                 425                 430         


Leu Met Val Asn Ser Arg Phe Gly Phe Gly Leu Leu Asn Ala Lys Ala 
        435                 440                 445             


Leu Val Asp Leu Ala Asp Pro Arg Thr Trp Arg Ser Val Pro Glu Lys 
    450                 455                 460                 


Lys Glu Cys Val Val Lys Asp Asn Asp Phe Glu Pro Arg Ala Leu Lys 
465                 470                 475                 480 


Ala Asn Gly Glu Val Ile Ile Glu Ile Pro Thr Arg Ala Cys Glu Gly 
                485                 490                 495     


Gln Glu Asn Ala Ile Lys Ser Leu Glu His Val Gln Phe Glu Ala Thr 
            500                 505                 510         


Ile Glu Tyr Ser Arg Arg Gly Asp Leu His Val Thr Leu Thr Ser Ala 
        515                 520                 525             


Ala Gly Thr Ser Thr Val Leu Leu Ala Glu Arg Glu Arg Asp Thr Ser 
    530                 535                 540                 


Pro Asn Gly Phe Lys Asn Trp Asp Phe Met Ser Val His Thr Trp Gly 
545                 550                 555                 560 


Glu Asn Pro Ile Gly Thr Trp Thr Leu Arg Ile Thr Asp Met Ser Gly 
                565                 570                 575     


Arg Ile Gln Asn Glu Gly Arg Ile Val Asn Trp Lys Leu Ile Leu His 
            580                 585                 590         


Gly Thr Ser Ser Gln Pro Glu His Met Lys Gln Pro Arg Val Tyr Thr 
        595                 600                 605             


Ser Tyr Asn Thr Val Gln Asn Asp Arg Arg Gly Val Glu Lys Met Val 
    610                 615                 620                 


Asp Pro Gly Glu Glu Gln Pro Thr Gln Glu Asn Pro Lys Glu Asn Thr 
625                 630                 635                 640 


Leu Val Ser Lys Ser Pro Ser Ser Ser Ser Val Gly Gly Arg Arg Asp 
                645                 650                 655     


Glu Leu Glu Glu Gly Ala Pro Ser Gln Ala Met Leu Arg Leu Leu Gln 
            660                 665                 670         


Ser Ala Phe Ser Lys Asn Ser Pro Pro Lys Gln Ser Pro Lys Lys Ser 
        675                 680                 685             


Pro Ser Ala Lys Leu Asn Ile Pro Tyr Glu Asn Phe Tyr Glu Ala Leu 
    690                 695                 700                 


Glu Lys Leu Asn Lys Pro Ser Gln Leu Lys Asp Ser Glu Asp Ser Leu 
705                 710                 715                 720 


Tyr Asn Asp Tyr Val Asp Val Phe Tyr Asn Thr Lys Pro Tyr Lys His 
                725                 730                 735     


Arg Asp Asp Arg Leu Leu Gln Ala Leu Val Asp Ile Leu Asn Glu Glu 
            740                 745                 750         


Asn 
    


<210>  10117
<211>  706
<212>  PRT
<213>  Homo Sapiens

<400>  10117

Met Gly Lys Gly Ser Ile Ser Phe Leu Phe Phe Ser Gln Ile Gly Ser 
1               5                   10                  15      


Leu Glu Asn His Tyr Leu Phe Lys His Lys Asn His Pro Arg Arg Ser 
            20                  25                  30          


Arg Arg Ser Ala Phe His Ile Thr Lys Arg Leu Ser Asp Asp Asp Arg 
        35                  40                  45              


Val Ile Trp Ala Glu Gln Gln Tyr Glu Lys Glu Arg Ser Lys Arg Ser 
    50                  55                  60                  


Ala Leu Arg Asp Ser Ala Leu Asn Leu Phe Asn Asp Pro Met Trp Asn 
65                  70                  75                  80  


Gln Gln Trp Tyr Leu Gln Asp Thr Arg Met Thr Ala Ala Leu Pro Lys 
                85                  90                  95      


Leu Asp Leu His Val Ile Pro Val Trp Gln Lys Gly Ile Thr Gly Lys 
            100                 105                 110         


Gly Val Val Ile Thr Val Leu Asp Asp Gly Leu Glu Trp Asn His Thr 
        115                 120                 125             


Asp Ile Tyr Ala Asn Tyr Asp Pro Glu Ala Ser Tyr Asp Phe Asn Asp 
    130                 135                 140                 


Asn Asp His Asp Pro Phe Pro Arg Tyr Asp Pro Thr Asn Glu Asn Lys 
145                 150                 155                 160 


His Gly Thr Arg Cys Ala Gly Glu Ile Ala Met Gln Ala Asn Asn His 
                165                 170                 175     


Lys Cys Gly Val Gly Val Ala Tyr Asn Ser Lys Val Gly Gly Ile Arg 
            180                 185                 190         


Met Leu Asp Gly Ile Val Thr Asp Ala Ile Glu Ala Ser Ser Ile Gly 
        195                 200                 205             


Phe Asn Pro Gly His Val Asp Ile Tyr Ser Ala Ser Trp Gly Pro Asn 
    210                 215                 220                 


Asp Asp Gly Lys Thr Val Glu Gly Pro Gly Arg Leu Ala Gln Lys Ala 
225                 230                 235                 240 


Phe Glu Tyr Gly Val Lys Gln Gly Arg Gln Gly Lys Gly Ser Ile Phe 
                245                 250                 255     


Val Trp Ala Ser Gly Asn Gly Gly Arg Gln Gly Asp Asn Cys Asp Cys 
            260                 265                 270         


Asp Gly Tyr Thr Asp Ser Ile Tyr Thr Ile Ser Ile Ser Ser Ala Ser 
        275                 280                 285             


Gln Gln Gly Leu Ser Pro Trp Tyr Ala Glu Lys Cys Ser Ser Thr Leu 
    290                 295                 300                 


Ala Thr Ser Tyr Ser Ser Gly Asp Tyr Thr Asp Gln Arg Ile Thr Ser 
305                 310                 315                 320 


Ala Asp Leu His Asn Asp Cys Thr Glu Thr His Thr Gly Thr Ser Ala 
                325                 330                 335     


Ser Ala Pro Leu Ala Ala Gly Ile Phe Ala Leu Ala Leu Glu Ala Asn 
            340                 345                 350         


Pro Asn Leu Thr Trp Arg Asp Met Gln His Leu Val Val Trp Thr Ser 
        355                 360                 365             


Glu Tyr Asp Pro Leu Ala Asn Asn Pro Gly Trp Lys Lys Asn Gly Ala 
    370                 375                 380                 


Gly Leu Met Val Asn Ser Arg Phe Gly Phe Gly Leu Leu Asn Ala Lys 
385                 390                 395                 400 


Ala Leu Val Asp Leu Ala Asp Pro Arg Thr Trp Arg Ser Val Pro Glu 
                405                 410                 415     


Lys Lys Glu Cys Val Val Lys Asp Asn Asp Phe Glu Pro Arg Ala Leu 
            420                 425                 430         


Lys Ala Asn Gly Glu Val Ile Ile Glu Ile Pro Thr Arg Ala Cys Glu 
        435                 440                 445             


Gly Gln Glu Asn Ala Ile Lys Ser Leu Glu His Val Gln Phe Glu Ala 
    450                 455                 460                 


Thr Ile Glu Tyr Ser Arg Arg Gly Asp Leu His Val Thr Leu Thr Ser 
465                 470                 475                 480 


Ala Ala Gly Thr Ser Thr Val Leu Leu Ala Glu Arg Glu Arg Asp Thr 
                485                 490                 495     


Ser Pro Asn Gly Phe Lys Asn Trp Asp Phe Met Ser Val His Thr Trp 
            500                 505                 510         


Gly Glu Asn Pro Ile Gly Thr Trp Thr Leu Arg Ile Thr Asp Met Ser 
        515                 520                 525             


Gly Arg Ile Gln Asn Glu Gly Arg Ile Val Asn Trp Lys Leu Ile Leu 
    530                 535                 540                 


His Gly Thr Ser Ser Gln Pro Glu His Met Lys Gln Pro Arg Val Tyr 
545                 550                 555                 560 


Thr Ser Tyr Asn Thr Val Gln Asn Asp Arg Arg Gly Val Glu Lys Met 
                565                 570                 575     


Val Asp Pro Gly Glu Glu Gln Pro Thr Gln Glu Asn Pro Lys Glu Asn 
            580                 585                 590         


Thr Leu Val Ser Lys Ser Pro Ser Ser Ser Ser Val Gly Gly Arg Arg 
        595                 600                 605             


Asp Glu Leu Glu Glu Gly Ala Pro Ser Gln Ala Met Leu Arg Leu Leu 
    610                 615                 620                 


Gln Ser Ala Phe Ser Lys Asn Ser Pro Pro Lys Gln Ser Pro Lys Lys 
625                 630                 635                 640 


Ser Pro Ser Ala Lys Leu Asn Ile Pro Tyr Glu Asn Phe Tyr Glu Ala 
                645                 650                 655     


Leu Glu Lys Leu Asn Lys Pro Ser Gln Leu Lys Asp Ser Glu Asp Ser 
            660                 665                 670         


Leu Tyr Asn Asp Tyr Val Asp Val Phe Tyr Asn Thr Lys Pro Tyr Lys 
        675                 680                 685             


His Arg Asp Asp Arg Leu Leu Gln Ala Leu Val Asp Ile Leu Asn Glu 
    690                 695                 700                 


Glu Asn 
705     


<210>  10118
<211>  260
<212>  PRT
<213>  Homo Sapiens

<400>  10118

Met Ala Gly Ser Pro Leu Leu Trp Gly Pro Arg Ala Gly Gly Val Gly 
1               5                   10                  15      


Leu Leu Val Leu Leu Leu Leu Gly Leu Phe Arg Pro Pro Pro Ala Leu 
            20                  25                  30          


Cys Ala Arg Pro Val Lys Glu Pro Arg Gly Leu Ser Ala Ala Ser Pro 
        35                  40                  45              


Pro Leu Ala Glu Thr Gly Ala Pro Arg Arg Phe Arg Arg Ser Val Pro 
    50                  55                  60                  


Arg Gly Glu Ala Ala Gly Ala Val Gln Glu Leu Ala Arg Ala Leu Ala 
65                  70                  75                  80  


His Leu Leu Glu Ala Glu Arg Gln Glu Arg Ala Arg Ala Glu Ala Gln 
                85                  90                  95      


Glu Ala Glu Asp Gln Gln Ala Arg Val Leu Ala Gln Leu Leu Arg Val 
            100                 105                 110         


Trp Gly Ala Pro Arg Asn Ser Asp Pro Ala Leu Gly Leu Asp Asp Asp 
        115                 120                 125             


Pro Asp Ala Pro Ala Ala Gln Leu Ala Arg Ala Leu Leu Arg Ala Arg 
    130                 135                 140                 


Leu Asp Pro Ala Ala Leu Ala Ala Gln Leu Val Pro Ala Pro Val Pro 
145                 150                 155                 160 


Ala Ala Ala Leu Arg Pro Arg Pro Pro Val Tyr Asp Asp Gly Pro Ala 
                165                 170                 175     


Gly Pro Asp Ala Glu Glu Ala Gly Asp Glu Thr Pro Asp Val Asp Pro 
            180                 185                 190         


Glu Leu Leu Arg Tyr Leu Leu Gly Arg Ile Leu Ala Gly Ser Ala Asp 
        195                 200                 205             


Ser Glu Gly Val Ala Ala Pro Arg Arg Leu Arg Arg Ala Ala Asp His 
    210                 215                 220                 


Asp Val Gly Ser Glu Leu Pro Pro Glu Gly Val Leu Gly Ala Leu Leu 
225                 230                 235                 240 


Arg Val Lys Arg Leu Glu Thr Pro Ala Pro Gln Val Pro Ala Arg Arg 
                245                 250                 255     


Leu Leu Pro Pro 
            260 


<210>  10119
<211>  638
<212>  PRT
<213>  Homo Sapiens

<400>  10119

Met Lys Gly Gly Cys Val Ser Gln Trp Lys Ala Ala Ala Gly Phe Leu 
1               5                   10                  15      


Phe Cys Val Met Val Phe Ala Ser Ala Glu Arg Pro Val Phe Thr Asn 
            20                  25                  30          


His Phe Leu Val Glu Leu His Lys Gly Gly Glu Asp Lys Ala Arg Gln 
        35                  40                  45              


Val Ala Ala Glu His Gly Phe Gly Val Arg Lys Leu Pro Phe Ala Glu 
    50                  55                  60                  


Gly Leu Tyr His Phe Tyr His Asn Gly Leu Ala Lys Ala Lys Arg Arg 
65                  70                  75                  80  


Arg Ser Leu His His Lys Gln Gln Leu Glu Arg Asp Pro Arg Val Lys 
                85                  90                  95      


Met Ala Leu Gln Gln Glu Gly Phe Asp Arg Lys Lys Arg Gly Tyr Arg 
            100                 105                 110         


Asp Ile Asn Glu Ile Asp Ile Asn Met Asn Asp Pro Leu Phe Thr Lys 
        115                 120                 125             


Gln Trp Tyr Leu Ile Asn Thr Gly Gln Ala Asp Gly Thr Pro Gly Leu 
    130                 135                 140                 


Asp Leu Asn Val Ala Glu Ala Trp Glu Leu Gly Tyr Thr Gly Lys Gly 
145                 150                 155                 160 


Val Thr Ile Gly Ile Met Asp Asp Gly Ile Asp Tyr Leu His Pro Asp 
                165                 170                 175     


Leu Ala Ser Asn Tyr Asn Ala Glu Ala Ser Tyr Asp Phe Ser Ser Asn 
            180                 185                 190         


Asp Pro Tyr Pro Tyr Pro Arg Tyr Thr Asp Asp Trp Phe Asn Ser His 
        195                 200                 205             


Gly Thr Arg Cys Ala Gly Glu Val Ser Ala Ala Ala Asn Asn Asn Ile 
    210                 215                 220                 


Cys Gly Val Gly Val Ala Tyr Asn Ser Lys Val Ala Gly Ile Arg Met 
225                 230                 235                 240 


Leu Asp Gln Pro Phe Met Thr Asp Ile Ile Glu Ala Ser Ser Ile Ser 
                245                 250                 255     


His Met Pro Gln Leu Ile Asp Ile Tyr Ser Ala Ser Trp Gly Pro Thr 
            260                 265                 270         


Asp Asn Gly Lys Thr Val Asp Gly Pro Arg Glu Leu Thr Leu Gln Ala 
        275                 280                 285             


Met Ala Asp Gly Val Asn Lys Gly Arg Gly Gly Lys Gly Ser Ile Tyr 
    290                 295                 300                 


Val Trp Ala Ser Gly Asp Gly Gly Ser Tyr Asp Asp Cys Asn Cys Asp 
305                 310                 315                 320 


Gly Tyr Ala Ser Ser Met Trp Thr Ile Ser Ile Asn Ser Ala Ile Asn 
                325                 330                 335     


Asp Gly Arg Thr Ala Leu Tyr Asp Glu Ser Cys Ser Ser Thr Leu Ala 
            340                 345                 350         


Ser Thr Phe Ser Asn Gly Arg Lys Arg Asn Pro Glu Ala Gly Val Ala 
        355                 360                 365             


Thr Thr Asp Leu Tyr Gly Asn Cys Thr Leu Arg His Ser Gly Thr Ser 
    370                 375                 380                 


Ala Ala Ala Pro Glu Ala Ala Gly Val Phe Ala Leu Ala Leu Glu Ala 
385                 390                 395                 400 


Asn Leu Gly Leu Thr Trp Arg Asp Met Gln His Leu Thr Val Leu Thr 
                405                 410                 415     


Ser Lys Arg Asn Gln Leu His Asp Glu Val His Gln Trp Arg Arg Asn 
            420                 425                 430         


Gly Val Gly Leu Glu Phe Asn His Leu Phe Gly Tyr Gly Val Leu Asp 
        435                 440                 445             


Ala Gly Ala Met Val Lys Met Ala Lys Asp Trp Lys Thr Val Pro Glu 
    450                 455                 460                 


Arg Phe His Cys Val Gly Gly Ser Val Gln Asp Pro Glu Lys Ile Pro 
465                 470                 475                 480 


Ser Thr Gly Lys Leu Val Leu Thr Leu Thr Thr Asp Ala Cys Glu Gly 
                485                 490                 495     


Lys Glu Asn Phe Val Arg Tyr Leu Glu His Val Gln Ala Val Ile Thr 
            500                 505                 510         


Val Asn Ala Thr Arg Arg Gly Asp Leu Asn Ile Asn Met Thr Ser Pro 
        515                 520                 525             


Met Gly Thr Lys Ser Ile Leu Leu Ser Arg Arg Pro Arg Asp Asp Asp 
    530                 535                 540                 


Ser Lys Val Gly Phe Asp Lys Trp Pro Phe Met Thr Thr His Thr Trp 
545                 550                 555                 560 


Gly Glu Asp Ala Arg Gly Thr Trp Thr Leu Glu Leu Gly Phe Val Gly 
                565                 570                 575     


Ser Ala Pro Gln Lys Gly Val Leu Lys Glu Trp Thr Leu Met Leu His 
            580                 585                 590         


Gly Thr Gln Ser Ala Pro Tyr Ile Asp Gln Val Val Arg Asp Tyr Gln 
        595                 600                 605             


Ser Lys Leu Ala Met Ser Lys Lys Glu Glu Leu Glu Glu Glu Leu Asp 
    610                 615                 620                 


Glu Ala Val Glu Arg Ser Leu Lys Ser Ile Leu Asn Lys Asn 
625                 630                 635             


<210>  10120
<211>  603
<212>  PRT
<213>  Homo Sapiens

<400>  10120

Met Lys Gly Gly Cys Val Ser Gln Trp Lys Ala Ala Ala Gly Phe Leu 
1               5                   10                  15      


Phe Cys Val Met Val Phe Ala Ser Ala Glu Arg Pro Val Phe Thr Asn 
            20                  25                  30          


His Phe Leu Val Glu Leu His Lys Gly Gly Glu Asp Lys Ala Arg Gln 
        35                  40                  45              


Val Ala Ala Glu His Gly Phe Gly Val Arg Lys Val Lys Met Ala Leu 
    50                  55                  60                  


Gln Gln Glu Gly Phe Asp Arg Lys Lys Arg Gly Tyr Arg Asp Ile Asn 
65                  70                  75                  80  


Glu Ile Asp Ile Asn Met Asn Asp Pro Leu Phe Thr Lys Gln Trp Tyr 
                85                  90                  95      


Leu Ile Asn Thr Gly Gln Ala Asp Gly Thr Pro Gly Leu Asp Leu Asn 
            100                 105                 110         


Val Ala Glu Ala Trp Glu Leu Gly Tyr Thr Gly Lys Gly Val Thr Ile 
        115                 120                 125             


Gly Ile Met Asp Asp Gly Ile Asp Tyr Leu His Pro Asp Leu Ala Ser 
    130                 135                 140                 


Asn Tyr Asn Ala Glu Ala Ser Tyr Asp Phe Ser Ser Asn Asp Pro Tyr 
145                 150                 155                 160 


Pro Tyr Pro Arg Tyr Thr Asp Asp Trp Phe Asn Ser His Gly Thr Arg 
                165                 170                 175     


Cys Ala Gly Glu Val Ser Ala Ala Ala Asn Asn Asn Ile Cys Gly Val 
            180                 185                 190         


Gly Val Ala Tyr Asn Ser Lys Val Ala Gly Ile Arg Met Leu Asp Gln 
        195                 200                 205             


Pro Phe Met Thr Asp Ile Ile Glu Ala Ser Ser Ile Ser His Met Pro 
    210                 215                 220                 


Gln Leu Ile Asp Ile Tyr Ser Ala Ser Trp Gly Pro Thr Asp Asn Gly 
225                 230                 235                 240 


Lys Thr Val Asp Gly Pro Arg Glu Leu Thr Leu Gln Ala Met Ala Asp 
                245                 250                 255     


Gly Val Asn Lys Gly Arg Gly Gly Lys Gly Ser Ile Tyr Val Trp Ala 
            260                 265                 270         


Ser Gly Asp Gly Gly Ser Tyr Asp Asp Cys Asn Cys Asp Gly Tyr Ala 
        275                 280                 285             


Ser Ser Met Trp Thr Ile Ser Ile Asn Ser Ala Ile Asn Asp Gly Arg 
    290                 295                 300                 


Thr Ala Leu Tyr Asp Glu Ser Cys Ser Ser Thr Leu Ala Ser Thr Phe 
305                 310                 315                 320 


Ser Asn Gly Arg Lys Arg Asn Pro Glu Ala Gly Val Ala Thr Thr Asp 
                325                 330                 335     


Leu Tyr Gly Asn Cys Thr Leu Arg His Ser Gly Thr Ser Ala Ala Ala 
            340                 345                 350         


Pro Glu Ala Ala Gly Val Phe Ala Leu Ala Leu Glu Ala Asn Leu Gly 
        355                 360                 365             


Leu Thr Trp Arg Asp Met Gln His Leu Thr Val Leu Thr Ser Lys Arg 
    370                 375                 380                 


Asn Gln Leu His Asp Glu Val His Gln Trp Arg Arg Asn Gly Val Gly 
385                 390                 395                 400 


Leu Glu Phe Asn His Leu Phe Gly Tyr Gly Val Leu Asp Ala Gly Ala 
                405                 410                 415     


Met Val Lys Met Ala Lys Asp Trp Lys Thr Val Pro Glu Arg Phe His 
            420                 425                 430         


Cys Val Gly Gly Ser Val Gln Asp Pro Glu Lys Ile Pro Ser Thr Gly 
        435                 440                 445             


Lys Leu Val Leu Thr Leu Thr Thr Asp Ala Cys Glu Gly Lys Glu Asn 
    450                 455                 460                 


Phe Val Arg Tyr Leu Glu His Val Gln Ala Val Ile Thr Val Asn Ala 
465                 470                 475                 480 


Thr Arg Arg Gly Asp Leu Asn Ile Asn Met Thr Ser Pro Met Gly Thr 
                485                 490                 495     


Lys Ser Ile Leu Leu Ser Arg Arg Pro Arg Asp Asp Asp Ser Lys Val 
            500                 505                 510         


Gly Phe Asp Lys Trp Pro Phe Met Thr Thr His Thr Trp Gly Glu Asp 
        515                 520                 525             


Ala Arg Gly Thr Trp Thr Leu Glu Leu Gly Phe Val Gly Ser Ala Pro 
    530                 535                 540                 


Gln Lys Gly Val Leu Lys Glu Trp Thr Leu Met Leu His Gly Thr Gln 
545                 550                 555                 560 


Ser Ala Pro Tyr Ile Asp Gln Val Val Arg Asp Tyr Gln Ser Lys Leu 
                565                 570                 575     


Ala Met Ser Lys Lys Glu Glu Leu Glu Glu Glu Leu Asp Glu Ala Val 
            580                 585                 590         


Glu Arg Ser Leu Lys Ser Ile Leu Asn Lys Asn 
        595                 600             


<210>  10121
<211>  619
<212>  PRT
<213>  Homo Sapiens

<400>  10121

Met Val Phe Ala Ser Ala Glu Arg Pro Val Phe Thr Asn His Phe Leu 
1               5                   10                  15      


Val Glu Leu His Lys Gly Gly Glu Asp Lys Ala Arg Gln Val Ala Ala 
            20                  25                  30          


Glu His Gly Phe Gly Val Arg Lys Leu Pro Phe Ala Glu Gly Leu Tyr 
        35                  40                  45              


His Phe Tyr His Asn Gly Leu Ala Lys Ala Lys Arg Arg Arg Ser Leu 
    50                  55                  60                  


His His Lys Gln Gln Leu Glu Arg Asp Pro Arg Val Lys Met Ala Leu 
65                  70                  75                  80  


Gln Gln Glu Gly Phe Asp Arg Lys Lys Arg Gly Tyr Arg Asp Ile Asn 
                85                  90                  95      


Glu Ile Asp Ile Asn Met Asn Asp Pro Leu Phe Thr Lys Gln Trp Tyr 
            100                 105                 110         


Leu Ile Asn Thr Gly Gln Ala Asp Gly Thr Pro Gly Leu Asp Leu Asn 
        115                 120                 125             


Val Ala Glu Ala Trp Glu Leu Gly Tyr Thr Gly Lys Gly Val Thr Ile 
    130                 135                 140                 


Gly Ile Met Asp Asp Gly Ile Asp Tyr Leu His Pro Asp Leu Ala Ser 
145                 150                 155                 160 


Asn Tyr Asn Ala Glu Ala Ser Tyr Asp Phe Ser Ser Asn Asp Pro Tyr 
                165                 170                 175     


Pro Tyr Pro Arg Tyr Thr Asp Asp Trp Phe Asn Ser His Gly Thr Arg 
            180                 185                 190         


Cys Ala Gly Glu Val Ser Ala Ala Ala Asn Asn Asn Ile Cys Gly Val 
        195                 200                 205             


Gly Val Ala Tyr Asn Ser Lys Val Ala Gly Ile Arg Met Leu Asp Gln 
    210                 215                 220                 


Pro Phe Met Thr Asp Ile Ile Glu Ala Ser Ser Ile Ser His Met Pro 
225                 230                 235                 240 


Gln Leu Ile Asp Ile Tyr Ser Ala Ser Trp Gly Pro Thr Asp Asn Gly 
                245                 250                 255     


Lys Thr Val Asp Gly Pro Arg Glu Leu Thr Leu Gln Ala Met Ala Asp 
            260                 265                 270         


Gly Val Asn Lys Gly Arg Gly Gly Lys Gly Ser Ile Tyr Val Trp Ala 
        275                 280                 285             


Ser Gly Asp Gly Gly Ser Tyr Asp Asp Cys Asn Cys Asp Gly Tyr Ala 
    290                 295                 300                 


Ser Ser Met Trp Thr Ile Ser Ile Asn Ser Ala Ile Asn Asp Gly Arg 
305                 310                 315                 320 


Thr Ala Leu Tyr Asp Glu Ser Cys Ser Ser Thr Leu Ala Ser Thr Phe 
                325                 330                 335     


Ser Asn Gly Arg Lys Arg Asn Pro Glu Ala Gly Val Ala Thr Thr Asp 
            340                 345                 350         


Leu Tyr Gly Asn Cys Thr Leu Arg His Ser Gly Thr Ser Ala Ala Ala 
        355                 360                 365             


Pro Glu Ala Ala Gly Val Phe Ala Leu Ala Leu Glu Ala Asn Leu Gly 
    370                 375                 380                 


Leu Thr Trp Arg Asp Met Gln His Leu Thr Val Leu Thr Ser Lys Arg 
385                 390                 395                 400 


Asn Gln Leu His Asp Glu Val His Gln Trp Arg Arg Asn Gly Val Gly 
                405                 410                 415     


Leu Glu Phe Asn His Leu Phe Gly Tyr Gly Val Leu Asp Ala Gly Ala 
            420                 425                 430         


Met Val Lys Met Ala Lys Asp Trp Lys Thr Val Pro Glu Arg Phe His 
        435                 440                 445             


Cys Val Gly Gly Ser Val Gln Asp Pro Glu Lys Ile Pro Ser Thr Gly 
    450                 455                 460                 


Lys Leu Val Leu Thr Leu Thr Thr Asp Ala Cys Glu Gly Lys Glu Asn 
465                 470                 475                 480 


Phe Val Arg Tyr Leu Glu His Val Gln Ala Val Ile Thr Val Asn Ala 
                485                 490                 495     


Thr Arg Arg Gly Asp Leu Asn Ile Asn Met Thr Ser Pro Met Gly Thr 
            500                 505                 510         


Lys Ser Ile Leu Leu Ser Arg Arg Pro Arg Asp Asp Asp Ser Lys Val 
        515                 520                 525             


Gly Phe Asp Lys Trp Pro Phe Met Thr Thr His Thr Trp Gly Glu Asp 
    530                 535                 540                 


Ala Arg Gly Thr Trp Thr Leu Glu Leu Gly Phe Val Gly Ser Ala Pro 
545                 550                 555                 560 


Gln Lys Gly Val Leu Lys Glu Trp Thr Leu Met Leu His Gly Thr Gln 
                565                 570                 575     


Ser Ala Pro Tyr Ile Asp Gln Val Val Arg Asp Tyr Gln Ser Lys Leu 
            580                 585                 590         


Ala Met Ser Lys Lys Glu Glu Leu Glu Glu Glu Leu Asp Glu Ala Val 
        595                 600                 605             


Glu Arg Ser Leu Lys Ser Ile Leu Asn Lys Asn 
    610                 615                 


<210>  10122
<211>  755
<212>  PRT
<213>  Homo Sapiens

<400>  10122

Met Arg Pro Ala Pro Ile Ala Leu Trp Leu Arg Leu Val Leu Ala Leu 
1               5                   10                  15      


Ala Leu Val Arg Pro Arg Ala Val Gly Trp Ala Pro Val Arg Ala Pro 
            20                  25                  30          


Ile Tyr Val Ser Ser Trp Ala Val Gln Val Ser Gln Gly Asn Arg Glu 
        35                  40                  45              


Val Glu Arg Leu Ala Arg Lys Phe Gly Phe Val Asn Leu Gly Pro Ile 
    50                  55                  60                  


Phe Pro Asp Gly Gln Tyr Phe His Leu Arg His Arg Gly Val Val Gln 
65                  70                  75                  80  


Gln Ser Leu Thr Pro His Trp Gly His Arg Leu His Leu Lys Lys Asn 
                85                  90                  95      


Pro Lys Val Gln Trp Phe Gln Gln Gln Thr Leu Gln Arg Arg Val Lys 
            100                 105                 110         


Arg Ser Val Val Val Pro Thr Asp Pro Trp Phe Ser Lys Gln Trp Tyr 
        115                 120                 125             


Met Asn Ser Glu Ala Gln Pro Asp Leu Ser Ile Leu Gln Ala Trp Ser 
    130                 135                 140                 


Gln Gly Leu Ser Gly Gln Gly Ile Val Val Ser Val Leu Asp Asp Gly 
145                 150                 155                 160 


Ile Glu Lys Asp His Pro Asp Leu Trp Ala Asn Tyr Asp Pro Leu Ala 
                165                 170                 175     


Ser Tyr Asp Phe Asn Asp Tyr Asp Pro Asp Pro Gln Pro Arg Tyr Thr 
            180                 185                 190         


Pro Ser Lys Glu Asn Arg His Gly Thr Arg Cys Ala Gly Glu Val Ala 
        195                 200                 205             


Ala Met Ala Asn Asn Gly Phe Cys Gly Val Gly Val Ala Phe Asn Ala 
    210                 215                 220                 


Arg Ile Gly Gly Val Arg Met Leu Asp Gly Thr Ile Thr Asp Val Ile 
225                 230                 235                 240 


Glu Ala Gln Ser Leu Ser Leu Gln Pro Gln His Ile His Ile Tyr Ser 
                245                 250                 255     


Ala Ser Trp Gly Pro Glu Asp Asp Gly Arg Thr Val Asp Gly Pro Gly 
            260                 265                 270         


Ile Leu Thr Arg Glu Ala Phe Arg Arg Gly Val Thr Lys Gly Arg Gly 
        275                 280                 285             


Gly Leu Gly Thr Leu Phe Ile Trp Ala Ser Gly Asn Gly Gly Leu His 
    290                 295                 300                 


Tyr Asp Asn Cys Asn Cys Asp Gly Tyr Thr Asn Ser Ile His Thr Leu 
305                 310                 315                 320 


Ser Val Gly Ser Thr Thr Gln Gln Gly Arg Val Pro Trp Tyr Ser Glu 
                325                 330                 335     


Ala Cys Ala Ser Thr Leu Thr Thr Thr Tyr Ser Ser Gly Val Ala Thr 
            340                 345                 350         


Asp Pro Gln Ile Val Thr Thr Asp Leu His His Gly Cys Thr Asp Gln 
        355                 360                 365             


His Thr Gly Thr Ser Ala Ser Ala Pro Leu Ala Ala Gly Met Ile Ala 
    370                 375                 380                 


Leu Ala Leu Glu Ala Asn Pro Phe Leu Thr Trp Arg Asp Met Gln His 
385                 390                 395                 400 


Leu Val Val Arg Ala Ser Lys Pro Ala His Leu Gln Ala Glu Asp Trp 
                405                 410                 415     


Arg Thr Asn Gly Val Gly Arg Gln Val Ser His His Tyr Gly Tyr Gly 
            420                 425                 430         


Leu Leu Asp Ala Gly Leu Leu Val Asp Thr Ala Arg Thr Trp Leu Pro 
        435                 440                 445             


Thr Gln Pro Gln Arg Lys Cys Ala Val Arg Val Gln Ser Arg Pro Thr 
    450                 455                 460                 


Pro Ile Leu Pro Leu Ile Tyr Ile Arg Glu Asn Val Ser Ala Cys Ala 
465                 470                 475                 480 


Gly Leu His Asn Ser Ile Arg Ser Leu Glu His Val Gln Ala Gln Leu 
                485                 490                 495     


Thr Leu Ser Tyr Ser Arg Arg Gly Asp Leu Glu Ile Ser Leu Thr Ser 
            500                 505                 510         


Pro Met Gly Thr Arg Ser Thr Leu Val Ala Ile Arg Pro Leu Asp Val 
        515                 520                 525             


Ser Thr Glu Gly Tyr Asn Asn Trp Val Phe Met Ser Thr His Phe Trp 
    530                 535                 540                 


Asp Glu Asn Pro Gln Gly Val Trp Thr Leu Gly Leu Glu Asn Lys Gly 
545                 550                 555                 560 


Tyr Tyr Phe Asn Thr Gly Thr Leu Tyr Arg Tyr Thr Leu Leu Leu Tyr 
                565                 570                 575     


Gly Thr Ala Glu Asp Met Thr Ala Arg Pro Thr Gly Pro Gln Val Thr 
            580                 585                 590         


Ser Ser Ala Cys Val Gln Arg Asp Thr Glu Gly Leu Cys Gln Ala Cys 
        595                 600                 605             


Asp Gly Pro Ala Tyr Ile Leu Gly Gln Leu Cys Leu Ala Tyr Cys Pro 
    610                 615                 620                 


Pro Arg Phe Phe Asn His Thr Arg Leu Val Thr Ala Gly Pro Gly His 
625                 630                 635                 640 


Thr Ala Ala Pro Ala Leu Arg Val Cys Ser Ser Cys His Ala Ser Cys 
                645                 650                 655     


Tyr Thr Cys Arg Gly Gly Ser Pro Arg Asp Cys Thr Ser Cys Pro Pro 
            660                 665                 670         


Ser Ser Thr Leu Asp Gln Gln Gln Gly Ser Cys Met Gly Pro Thr Thr 
        675                 680                 685             


Pro Asp Ser Arg Pro Arg Leu Arg Ala Ala Ala Cys Pro His His Arg 
    690                 695                 700                 


Cys Pro Ala Ser Ala Met Val Leu Ser Leu Leu Ala Val Thr Leu Gly 
705                 710                 715                 720 


Gly Pro Val Leu Cys Gly Met Ser Met Asp Leu Pro Leu Tyr Ala Trp 
                725                 730                 735     


Leu Ser Arg Ala Arg Ala Thr Pro Thr Lys Pro Gln Val Trp Leu Pro 
            740                 745                 750         


Ala Gly Thr 
        755 


<210>  10123
<211>  230
<212>  PRT
<213>  Homo Sapiens

<400>  10123

Met Arg Pro Ala Pro Ile Ala Leu Trp Leu Arg Leu Val Leu Ala Leu 
1               5                   10                  15      


Ala Leu Val Arg Pro Arg Ala Val Gly Trp Ala Pro Val Arg Ala Pro 
            20                  25                  30          


Ile Tyr Val Ser Ser Trp Ala Val Gln Val Ser Gln Gly Asn Arg Glu 
        35                  40                  45              


Val Glu Arg Leu Ala Arg Lys Phe Gly Phe Val Asn Leu Gly Pro Ile 
    50                  55                  60                  


Phe Pro Asp Gly Gln Tyr Phe His Leu Arg His Arg Gly Val Val Gln 
65                  70                  75                  80  


Gln Ser Leu Thr Pro His Trp Gly His Arg Leu His Leu Lys Lys Asn 
                85                  90                  95      


Pro Lys Val Gln Trp Phe Gln Gln Gln Thr Leu Gln Arg Arg Val Lys 
            100                 105                 110         


Arg Ser Val Val Val Pro Thr Asp Pro Trp Phe Ser Lys Gln Trp Tyr 
        115                 120                 125             


Met Asn Ser Glu Ala Gln Pro Asp Leu Ser Ile Leu Gln Ala Trp Ser 
    130                 135                 140                 


Gln Gly Leu Ser Gly Gln Gly Ile Val Val Ser Val Leu Asp Asp Gly 
145                 150                 155                 160 


Ile Glu Lys Asp His Pro Asp Leu Trp Ala Asn Tyr Asp Pro Leu Ala 
                165                 170                 175     


Ser Tyr Asp Phe Asn Asp Tyr Asp Pro Asp Pro Gln Pro Arg Tyr Thr 
            180                 185                 190         


Pro Ser Lys Glu Asn Arg Arg Thr Asp Ala Gly Arg Tyr His His Arg 
        195                 200                 205             


Cys His Arg Gly Pro Val Ala Glu Pro Ala Ala Ala Ala His Pro His 
    210                 215                 220                 


Leu Gln Arg Gln Leu Gly 
225                 230 


<210>  10124
<211>  318
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  10124

Xaa Pro Ile Ala Leu Trp Leu Arg Leu Val Leu Ala Leu Ala Leu Val 
1               5                   10                  15      


Arg Pro Arg Ala Val Gly Trp Ala Pro Val Arg Ala Pro Ile Tyr Val 
            20                  25                  30          


Ser Ser Trp Ala Val Gln Val Ser Gln Gly Asn Arg Glu Val Glu Arg 
        35                  40                  45              


Leu Ala Arg Lys Phe Gly Phe Val Asn Leu Gly Pro Ile Phe Pro Asp 
    50                  55                  60                  


Gly Gln Tyr Phe His Leu Arg His Arg Gly Val Val Gln Gln Ser Leu 
65                  70                  75                  80  


Thr Pro His Trp Gly His Arg Leu His Leu Lys Lys Asn Pro Lys Val 
                85                  90                  95      


Gln Trp Phe Gln Gln Gln Thr Leu Gln Arg Arg Val Lys Arg Ser Val 
            100                 105                 110         


Val Val Pro Thr Asp Pro Trp Phe Ser Lys Gln Trp Tyr Met Asn Ser 
        115                 120                 125             


Glu Ala Gln Pro Asp Leu Ser Ile Leu Gln Ala Trp Ser Gln Gly Leu 
    130                 135                 140                 


Ser Gly Gln Gly Ile Val Val Ser Val Leu Asp Asp Gly Ile Glu Lys 
145                 150                 155                 160 


Asp His Pro Asp Leu Trp Ala Asn Tyr Asp Pro Leu Ala Ser Tyr Asp 
                165                 170                 175     


Phe Asn Asp Tyr Asp Pro Asp Pro Gln Pro Arg Tyr Thr Pro Ser Lys 
            180                 185                 190         


Glu Asn Arg Arg Thr Asp Ala Gly Arg Tyr His His Arg Cys His Arg 
        195                 200                 205             


Gly Pro Val Ala Glu Pro Ala Ala Ala Ala His Pro His Leu Gln Arg 
    210                 215                 220                 


Gln Leu Gly Ser Arg Gly Arg Arg Pro His Gly Gly Arg Pro Arg His 
225                 230                 235                 240 


Pro His Pro Arg Gly Leu Pro Ala Trp Cys Asp Gln Ala Ser Thr Arg 
                245                 250                 255     


Phe Pro Trp Ala Ala Pro Pro Ser Arg Ala Ala Cys Pro Gly Thr Ala 
            260                 265                 270         


Lys Pro Ala Pro Pro Pro Ser Pro Pro Pro Thr Ala Ala Ala Trp Pro 
        275                 280                 285             


Pro Thr Pro Arg Ser Ser Pro Arg Thr Cys Ile Thr Gly Ala Gln Thr 
    290                 295                 300                 


Ser Thr Arg Ala Pro Arg Pro Gln Pro His Trp Arg Pro Ala 
305                 310                 315             


<210>  10125
<211>  101
<212>  PRT
<213>  Homo Sapiens

<400>  10125

Cys Gln Pro Cys His Arg Phe Cys Ala Thr Cys Ala Gly Ala Gly Ala 
1               5                   10                  15      


Asp Gly Cys Ile Asn Cys Thr Glu Gly Tyr Phe Met Glu Asp Gly Arg 
            20                  25                  30          


Cys Val Gln Ser Cys Ser Ile Ser Tyr Tyr Phe Asp His Ser Ser Glu 
        35                  40                  45              


Asn Gly Tyr Lys Ser Cys Lys Lys Cys Asp Ile Ser Cys Leu Thr Cys 
    50                  55                  60                  


Asn Gly Pro Gly Phe Lys Asn Cys Thr Ser Cys Pro Ser Gly Tyr Leu 
65                  70                  75                  80  


Leu Asp Leu Gly Met Cys Gln Met Gly Ala Ile Cys Lys Asp Val Ser 
                85                  90                  95      


Leu Phe Arg Gly Ala 
            100     


<210>  10126
<211>  690
<212>  PRT
<213>  Homo Sapiens

<400>  10126

Met Gly Trp Gly Ser Arg Cys Cys Cys Pro Gly Arg Leu Asp Leu Leu 
1               5                   10                  15      


Cys Val Leu Ala Leu Leu Gly Gly Cys Leu Leu Pro Val Cys Arg Thr 
            20                  25                  30          


Arg Val Tyr Thr Asn His Trp Ala Val Lys Ile Ala Gly Gly Phe Pro 
        35                  40                  45              


Glu Ala Asn Arg Ile Ala Ser Lys Tyr Gly Phe Ile Asn Ile Gly Gln 
    50                  55                  60                  


Ile Gly Ala Leu Lys Asp Tyr Tyr His Phe Tyr His Ser Arg Thr Ile 
65                  70                  75                  80  


Lys Arg Ser Val Ile Ser Ser Arg Gly Thr His Ser Phe Ile Ser Met 
                85                  90                  95      


Glu Pro Lys Val Glu Trp Ile Gln Gln Gln Val Val Lys Lys Arg Thr 
            100                 105                 110         


Lys Arg Asp Tyr Asp Phe Ser Arg Ala Gln Ser Thr Tyr Phe Asn Asp 
        115                 120                 125             


Pro Lys Trp Pro Ser Met Trp Tyr Met His Cys Ser Asp Asn Thr His 
    130                 135                 140                 


Pro Cys Gln Ser Asp Met Asn Ile Glu Gly Ala Trp Lys Arg Gly Tyr 
145                 150                 155                 160 


Thr Gly Lys Asn Ile Val Val Thr Ile Leu Asp Asp Gly Ile Glu Arg 
                165                 170                 175     


Thr His Pro Asp Leu Met Gln Asn Tyr Asp Ala Leu Ala Ser Cys Asp 
            180                 185                 190         


Val Asn Gly Asn Asp Leu Asp Pro Met Pro Arg Tyr Asp Ala Ser Asn 
        195                 200                 205             


Glu Asn Lys His Gly Thr Arg Cys Ala Gly Glu Val Ala Ala Ala Ala 
    210                 215                 220                 


Asn Asn Ser His Cys Thr Val Gly Ile Ala Phe Asn Ala Lys Ile Gly 
225                 230                 235                 240 


Gly Val Arg Met Leu Asp Gly Asp Val Thr Asp Met Val Glu Ala Lys 
                245                 250                 255     


Ser Val Ser Phe Asn Pro Gln His Val His Ile Tyr Ser Ala Ser Trp 
            260                 265                 270         


Gly Pro Asp Asp Asp Gly Lys Thr Val Asp Gly Pro Ala Pro Leu Thr 
        275                 280                 285             


Arg Gln Ala Phe Glu Asn Gly Val Arg Met Gly Arg Arg Gly Leu Gly 
    290                 295                 300                 


Ser Val Phe Val Trp Ala Ser Gly Asn Gly Gly Arg Ser Lys Asp His 
305                 310                 315                 320 


Cys Ser Cys Asp Gly Tyr Thr Asn Ser Ile Tyr Thr Ile Ser Ile Ser 
                325                 330                 335     


Ser Thr Ala Glu Ser Gly Lys Lys Pro Trp Tyr Leu Glu Glu Cys Ser 
            340                 345                 350         


Ser Thr Leu Ala Thr Thr Tyr Ser Ser Gly Glu Ser Tyr Asp Lys Lys 
        355                 360                 365             


Ile Ile Thr Thr Asp Leu Arg Gln Arg Cys Thr Asp Asn His Thr Gly 
    370                 375                 380                 


Thr Ser Ala Ser Ala Pro Met Ala Ala Gly Ile Ile Ala Leu Ala Leu 
385                 390                 395                 400 


Glu Ala Asn Pro Phe Leu Thr Trp Arg Asp Val Gln His Val Ile Val 
                405                 410                 415     


Arg Thr Ser Arg Ala Gly His Leu Asn Ala Asn Asp Trp Lys Thr Asn 
            420                 425                 430         


Ala Ala Gly Phe Lys Val Ser His Leu Tyr Gly Phe Gly Leu Met Asp 
        435                 440                 445             


Ala Glu Ala Met Val Met Glu Ala Glu Lys Trp Thr Thr Val Pro Arg 
    450                 455                 460                 


Gln His Val Cys Val Glu Ser Thr Asp Arg Gln Ile Lys Thr Ile Arg 
465                 470                 475                 480 


Pro Asn Ser Ala Val Arg Ser Ile Tyr Lys Ala Ser Gly Cys Ser Asp 
                485                 490                 495     


Asn Pro Asn Arg His Val Asn Tyr Leu Glu His Val Val Val Arg Ile 
            500                 505                 510         


Thr Ile Thr His Pro Arg Arg Gly Asp Leu Ala Ile Tyr Leu Thr Ser 
        515                 520                 525             


Pro Ser Gly Thr Arg Ser Gln Leu Leu Ala Asn Arg Leu Phe Asp His 
    530                 535                 540                 


Ser Met Glu Gly Phe Lys Asn Trp Glu Phe Met Thr Ile His Cys Trp 
545                 550                 555                 560 


Gly Glu Arg Ala Ala Gly Asp Trp Val Leu Glu Val Tyr Asp Thr Pro 
                565                 570                 575     


Ser Gln Leu Arg Asn Phe Lys Thr Pro Gly Lys Leu Lys Glu Trp Ser 
            580                 585                 590         


Leu Val Leu Tyr Gly Thr Ser Val Gln Pro Tyr Ser Pro Thr Asn Glu 
        595                 600                 605             


Phe Pro Lys Val Glu Arg Phe Arg Tyr Ser Arg Val Glu Asp Pro Thr 
    610                 615                 620                 


Asp Asp Tyr Gly Thr Glu Asp Tyr Ala Gly Glu Leu Ala Ser Ser Gly 
625                 630                 635                 640 


Thr Gln Ala Lys Lys Arg Gln Leu Met His His Pro Thr Thr Trp Glu 
                645                 650                 655     


Asn Arg Met Glu Trp Asn Gly Met Lys Trp Asn Gly Met Lys Trp Asn 
            660                 665                 670         


Gly Met Glu Trp Asn Gly Met Glu Trp Asn Arg Ile Glu Ser Asn Arg 
        675                 680                 685             


Ile Glu 
    690 


<210>  10127
<211>  913
<212>  PRT
<213>  Homo Sapiens

<400>  10127

Met Gly Trp Gly Ser Arg Cys Cys Cys Pro Gly Arg Leu Asp Leu Leu 
1               5                   10                  15      


Cys Val Leu Ala Leu Leu Gly Gly Cys Leu Leu Pro Val Cys Arg Thr 
            20                  25                  30          


Arg Val Tyr Thr Asn His Trp Ala Val Lys Ile Ala Gly Gly Phe Pro 
        35                  40                  45              


Glu Ala Asn Arg Ile Ala Ser Lys Tyr Gly Phe Ile Asn Ile Gly Gln 
    50                  55                  60                  


Ile Gly Ala Leu Lys Asp Tyr Tyr His Phe Tyr His Ser Arg Thr Ile 
65                  70                  75                  80  


Lys Arg Ser Val Ile Ser Ser Arg Gly Thr His Ser Phe Ile Ser Met 
                85                  90                  95      


Glu Pro Lys Val Glu Trp Ile Gln Gln Gln Val Val Lys Lys Arg Thr 
            100                 105                 110         


Lys Arg Asp Tyr Asp Phe Ser Arg Ala Gln Ser Thr Tyr Phe Asn Asp 
        115                 120                 125             


Pro Lys Trp Pro Ser Met Trp Tyr Met His Cys Ser Asp Asn Thr His 
    130                 135                 140                 


Pro Cys Gln Ser Asp Met Asn Ile Glu Gly Ala Trp Lys Arg Gly Tyr 
145                 150                 155                 160 


Thr Gly Lys Asn Ile Val Val Thr Ile Leu Asp Asp Gly Ile Glu Arg 
                165                 170                 175     


Thr His Pro Asp Leu Met Gln Asn Tyr Asp Ala Leu Ala Ser Cys Asp 
            180                 185                 190         


Val Asn Gly Asn Asp Leu Asp Pro Met Pro Arg Tyr Asp Ala Ser Asn 
        195                 200                 205             


Glu Asn Lys His Gly Thr Arg Cys Ala Gly Glu Val Ala Ala Ala Ala 
    210                 215                 220                 


Asn Asn Ser His Cys Thr Val Gly Ile Ala Phe Asn Ala Lys Ile Gly 
225                 230                 235                 240 


Gly Val Arg Met Leu Asp Gly Asp Val Thr Asp Met Val Glu Ala Lys 
                245                 250                 255     


Ser Val Ser Phe Asn Pro Gln His Val His Ile Tyr Ser Ala Ser Trp 
            260                 265                 270         


Gly Pro Asp Asp Asp Gly Lys Thr Val Asp Gly Pro Ala Pro Leu Thr 
        275                 280                 285             


Arg Gln Ala Phe Glu Asn Gly Val Arg Met Gly Arg Arg Gly Leu Gly 
    290                 295                 300                 


Ser Val Phe Val Trp Ala Ser Gly Asn Gly Gly Arg Ser Lys Asp His 
305                 310                 315                 320 


Cys Ser Cys Asp Gly Tyr Thr Asn Ser Ile Tyr Thr Ile Ser Ile Ser 
                325                 330                 335     


Ser Thr Ala Glu Ser Gly Lys Lys Pro Trp Tyr Leu Glu Glu Cys Ser 
            340                 345                 350         


Ser Thr Leu Ala Thr Thr Tyr Ser Ser Gly Glu Ser Tyr Asp Lys Lys 
        355                 360                 365             


Ile Ile Thr Thr Asp Leu Arg Gln Arg Cys Thr Asp Asn His Thr Gly 
    370                 375                 380                 


Thr Ser Ala Ser Ala Pro Met Ala Ala Gly Ile Ile Ala Leu Ala Leu 
385                 390                 395                 400 


Glu Ala Asn Pro Phe Leu Thr Trp Arg Asp Val Gln His Val Ile Val 
                405                 410                 415     


Arg Thr Ser Arg Ala Gly His Leu Asn Ala Asn Asp Trp Lys Thr Asn 
            420                 425                 430         


Ala Ala Gly Phe Lys Val Ser His Leu Tyr Gly Phe Gly Leu Met Asp 
        435                 440                 445             


Ala Glu Ala Met Val Met Glu Ala Glu Lys Trp Thr Thr Val Pro Arg 
    450                 455                 460                 


Gln His Val Cys Val Glu Ser Thr Asp Arg Gln Ile Lys Thr Ile Arg 
465                 470                 475                 480 


Pro Asn Ser Ala Val Arg Ser Ile Tyr Lys Ala Ser Gly Cys Ser Asp 
                485                 490                 495     


Asn Pro Asn Arg His Val Asn Tyr Leu Glu His Val Val Val Arg Ile 
            500                 505                 510         


Thr Ile Thr His Pro Arg Arg Gly Asp Leu Ala Ile Tyr Leu Thr Ser 
        515                 520                 525             


Pro Ser Gly Thr Arg Ser Gln Leu Leu Ala Asn Arg Leu Phe Asp His 
    530                 535                 540                 


Ser Met Glu Gly Phe Lys Asn Trp Glu Phe Met Thr Ile His Cys Trp 
545                 550                 555                 560 


Gly Glu Arg Ala Ala Gly Asp Trp Val Leu Glu Val Tyr Asp Thr Pro 
                565                 570                 575     


Ser Gln Leu Arg Asn Phe Lys Thr Pro Gly Lys Leu Lys Glu Trp Ser 
            580                 585                 590         


Leu Val Leu Tyr Gly Thr Ser Val Gln Pro Tyr Ser Pro Thr Asn Glu 
        595                 600                 605             


Phe Pro Lys Val Glu Arg Phe Arg Tyr Ser Arg Val Glu Asp Pro Thr 
    610                 615                 620                 


Asp Asp Tyr Gly Thr Glu Asp Tyr Ala Gly Pro Cys Asp Pro Glu Cys 
625                 630                 635                 640 


Ser Glu Val Gly Cys Asp Gly Pro Gly Pro Asp His Cys Asn Asp Cys 
                645                 650                 655     


Leu His Tyr Tyr Tyr Lys Leu Lys Asn Asn Thr Arg Ile Cys Val Ser 
            660                 665                 670         


Ser Cys Pro Pro Gly His Tyr His Ala Asp Lys Lys Arg Cys Arg Lys 
        675                 680                 685             


Cys Ala Pro Asn Cys Glu Ser Cys Phe Gly Ser His Gly Asp Gln Cys 
    690                 695                 700                 


Met Ser Cys Lys Tyr Gly Tyr Phe Leu Asn Glu Glu Thr Asn Ser Cys 
705                 710                 715                 720 


Val Thr His Cys Pro Asp Gly Ser Tyr Gln Asp Thr Lys Lys Asn Leu 
                725                 730                 735     


Cys Arg Lys Cys Ser Glu Asn Cys Lys Thr Cys Thr Glu Phe His Asn 
            740                 745                 750         


Cys Thr Glu Cys Arg Asp Gly Leu Ser Leu Gln Gly Ser Arg Cys Ser 
        755                 760                 765             


Val Ser Cys Glu Asp Gly Arg Tyr Phe Asn Gly Gln Asp Cys Gln Pro 
    770                 775                 780                 


Cys His Arg Phe Cys Ala Thr Cys Ala Gly Ala Gly Ala Asp Gly Cys 
785                 790                 795                 800 


Ile Asn Cys Thr Glu Gly Tyr Phe Met Glu Asp Gly Arg Cys Val Gln 
                805                 810                 815     


Ser Cys Ser Ile Ser Tyr Tyr Phe Asp His Ser Ser Glu Asn Gly Tyr 
            820                 825                 830         


Lys Ser Cys Lys Lys Cys Asp Ile Ser Cys Leu Thr Cys Asn Gly Pro 
        835                 840                 845             


Gly Phe Lys Asn Cys Thr Ser Cys Pro Ser Gly Tyr Leu Leu Asp Leu 
    850                 855                 860                 


Gly Met Cys Gln Met Gly Ala Ile Cys Lys Asp Ala Thr Glu Glu Ser 
865                 870                 875                 880 


Trp Ala Glu Gly Gly Phe Cys Met Leu Val Lys Lys Asn Asn Leu Cys 
                885                 890                 895     


Gln Arg Lys Val Leu Gln Gln Leu Cys Cys Lys Thr Cys Thr Phe Gln 
            900                 905                 910         


Gly 
    


<210>  10128
<211>  1860
<212>  PRT
<213>  Homo Sapiens

<400>  10128

Met Gly Trp Gly Ser Arg Cys Cys Cys Pro Gly Arg Leu Asp Leu Leu 
1               5                   10                  15      


Cys Val Leu Ala Leu Leu Gly Gly Cys Leu Leu Pro Val Cys Arg Thr 
            20                  25                  30          


Arg Val Tyr Thr Asn His Trp Ala Val Lys Ile Ala Gly Gly Phe Pro 
        35                  40                  45              


Glu Ala Asn Arg Ile Ala Ser Lys Tyr Gly Phe Ile Asn Ile Gly Gln 
    50                  55                  60                  


Ile Gly Ala Leu Lys Asp Tyr Tyr His Phe Tyr His Ser Arg Thr Ile 
65                  70                  75                  80  


Lys Arg Ser Val Ile Ser Ser Arg Gly Thr His Ser Phe Ile Ser Met 
                85                  90                  95      


Glu Pro Lys Val Glu Trp Ile Gln Gln Gln Val Val Lys Lys Arg Thr 
            100                 105                 110         


Lys Arg Asp Tyr Asp Phe Ser Arg Ala Gln Ser Thr Tyr Phe Asn Asp 
        115                 120                 125             


Pro Lys Trp Pro Ser Met Trp Tyr Met His Cys Ser Asp Asn Thr His 
    130                 135                 140                 


Pro Cys Gln Ser Asp Met Asn Ile Glu Gly Ala Trp Lys Arg Gly Tyr 
145                 150                 155                 160 


Thr Gly Lys Asn Ile Val Val Thr Ile Leu Asp Asp Gly Ile Glu Arg 
                165                 170                 175     


Thr His Pro Asp Leu Met Gln Asn Tyr Asp Ala Leu Ala Ser Cys Asp 
            180                 185                 190         


Val Asn Gly Asn Asp Leu Asp Pro Met Pro Arg Tyr Asp Ala Ser Asn 
        195                 200                 205             


Glu Asn Lys His Gly Thr Arg Cys Ala Gly Glu Val Ala Ala Ala Ala 
    210                 215                 220                 


Asn Asn Ser His Cys Thr Val Gly Ile Ala Phe Asn Ala Lys Ile Gly 
225                 230                 235                 240 


Gly Val Arg Met Leu Asp Gly Asp Val Thr Asp Met Val Glu Ala Lys 
                245                 250                 255     


Ser Val Ser Phe Asn Pro Gln His Val His Ile Tyr Ser Ala Ser Trp 
            260                 265                 270         


Gly Pro Asp Asp Asp Gly Lys Thr Val Asp Gly Pro Ala Pro Leu Thr 
        275                 280                 285             


Arg Gln Ala Phe Glu Asn Gly Val Arg Met Gly Arg Arg Gly Leu Gly 
    290                 295                 300                 


Ser Val Phe Val Trp Ala Ser Gly Asn Gly Gly Arg Ser Lys Asp His 
305                 310                 315                 320 


Cys Ser Cys Asp Gly Tyr Thr Asn Ser Ile Tyr Thr Ile Ser Ile Ser 
                325                 330                 335     


Ser Thr Ala Glu Ser Gly Lys Lys Pro Trp Tyr Leu Glu Glu Cys Ser 
            340                 345                 350         


Ser Thr Leu Ala Thr Thr Tyr Ser Ser Gly Glu Ser Tyr Asp Lys Lys 
        355                 360                 365             


Ile Ile Thr Thr Asp Leu Arg Gln Arg Cys Thr Asp Asn His Thr Gly 
    370                 375                 380                 


Thr Ser Ala Ser Ala Pro Met Ala Ala Gly Ile Ile Ala Leu Ala Leu 
385                 390                 395                 400 


Glu Ala Asn Pro Phe Leu Thr Trp Arg Asp Val Gln His Val Ile Val 
                405                 410                 415     


Arg Thr Ser Arg Ala Gly His Leu Asn Ala Asn Asp Trp Lys Thr Asn 
            420                 425                 430         


Ala Ala Gly Phe Lys Val Ser His Leu Tyr Gly Phe Gly Leu Met Asp 
        435                 440                 445             


Ala Glu Ala Met Val Met Glu Ala Glu Lys Trp Thr Thr Val Pro Arg 
    450                 455                 460                 


Gln His Val Cys Val Glu Ser Thr Asp Arg Gln Ile Lys Thr Ile Arg 
465                 470                 475                 480 


Pro Asn Ser Ala Val Arg Ser Ile Tyr Lys Ala Ser Gly Cys Ser Asp 
                485                 490                 495     


Asn Pro Asn Arg His Val Asn Tyr Leu Glu His Val Val Val Arg Ile 
            500                 505                 510         


Thr Ile Thr His Pro Arg Arg Gly Asp Leu Ala Ile Tyr Leu Thr Ser 
        515                 520                 525             


Pro Ser Gly Thr Arg Ser Gln Leu Leu Ala Asn Arg Leu Phe Asp His 
    530                 535                 540                 


Ser Met Glu Gly Phe Lys Asn Trp Glu Phe Met Thr Ile His Cys Trp 
545                 550                 555                 560 


Gly Glu Arg Ala Ala Gly Asp Trp Val Leu Glu Val Tyr Asp Thr Pro 
                565                 570                 575     


Ser Gln Leu Arg Asn Phe Lys Thr Pro Gly Lys Leu Lys Glu Trp Ser 
            580                 585                 590         


Leu Val Leu Tyr Gly Thr Ser Val Gln Pro Tyr Ser Pro Thr Asn Glu 
        595                 600                 605             


Phe Pro Lys Val Glu Arg Phe Arg Tyr Ser Arg Val Glu Asp Pro Thr 
    610                 615                 620                 


Asp Asp Tyr Gly Thr Glu Asp Tyr Ala Gly Pro Cys Asp Pro Glu Cys 
625                 630                 635                 640 


Ser Glu Val Gly Cys Asp Gly Pro Gly Pro Asp His Cys Asn Asp Cys 
                645                 650                 655     


Leu His Tyr Tyr Tyr Lys Leu Lys Asn Asn Thr Arg Ile Cys Val Ser 
            660                 665                 670         


Ser Cys Pro Pro Gly His Tyr His Ala Asp Lys Lys Arg Cys Arg Lys 
        675                 680                 685             


Cys Ala Pro Asn Cys Glu Ser Cys Phe Gly Ser His Gly Asp Gln Cys 
    690                 695                 700                 


Met Ser Cys Lys Tyr Gly Tyr Phe Leu Asn Glu Glu Thr Asn Ser Cys 
705                 710                 715                 720 


Val Thr His Cys Pro Asp Gly Ser Tyr Gln Asp Thr Lys Lys Asn Leu 
                725                 730                 735     


Cys Arg Lys Cys Ser Glu Asn Cys Lys Thr Cys Thr Glu Phe His Asn 
            740                 745                 750         


Cys Thr Glu Cys Arg Asp Gly Leu Ser Leu Gln Gly Ser Arg Cys Ser 
        755                 760                 765             


Val Ser Cys Glu Asp Gly Arg Tyr Phe Asn Gly Gln Asp Cys Gln Pro 
    770                 775                 780                 


Cys His Arg Phe Cys Ala Thr Cys Ala Gly Ala Gly Ala Asp Gly Cys 
785                 790                 795                 800 


Ile Asn Cys Thr Glu Gly Tyr Phe Met Glu Asp Gly Arg Cys Val Gln 
                805                 810                 815     


Ser Cys Ser Ile Ser Tyr Tyr Phe Asp His Ser Ser Glu Asn Gly Tyr 
            820                 825                 830         


Lys Ser Cys Lys Lys Cys Asp Ile Ser Cys Leu Thr Cys Asn Gly Pro 
        835                 840                 845             


Gly Phe Lys Asn Cys Thr Ser Cys Pro Ser Gly Tyr Leu Leu Asp Leu 
    850                 855                 860                 


Gly Met Cys Gln Met Gly Ala Ile Cys Lys Asp Gly Glu Tyr Val Asp 
865                 870                 875                 880 


Glu His Gly His Cys Gln Thr Cys Glu Ala Ser Cys Ala Lys Cys Gln 
                885                 890                 895     


Gly Pro Thr Gln Glu Asp Cys Thr Thr Cys Pro Met Thr Arg Ile Phe 
            900                 905                 910         


Asp Asp Gly Arg Cys Val Ser Asn Cys Pro Ser Trp Lys Phe Glu Phe 
        915                 920                 925             


Glu Asn Gln Cys His Pro Cys His His Thr Cys Gln Arg Cys Gln Gly 
    930                 935                 940                 


Ser Gly Pro Thr His Cys Thr Ser Cys Gly Ala Asp Asn Tyr Gly Arg 
945                 950                 955                 960 


Glu His Phe Leu Tyr Gln Gly Glu Cys Gly Asp Ser Cys Pro Glu Gly 
                965                 970                 975     


His Tyr Ala Thr Glu Gly Asn Thr Cys Leu Pro Cys Pro Asp Asn Cys 
            980                 985                 990         


Glu Leu Cys His Ser Val His Val  Cys Thr Arg Cys Met  Lys Gly Tyr 
        995                 1000                 1005             


Phe Ile  Ala Pro Thr Asn His  Thr Cys Gln Lys Leu  Glu Cys Gly 
    1010                 1015                 1020             


Gln Gly  Glu Val Gln Asp Pro  Asp Tyr Glu Glu Cys  Val Pro Cys 
    1025                 1030                 1035             


Glu Glu  Gly Cys Leu Gly Cys  Ser Leu Asp Asp Pro  Gly Thr Cys 
    1040                 1045                 1050             


Thr Ser  Cys Ala Met Gly Tyr  Tyr Arg Phe Asp His  His Cys Tyr 
    1055                 1060                 1065             


Lys Thr  Cys Pro Glu Lys Thr  Tyr Ser Glu Glu Val  Glu Cys Lys 
    1070                 1075                 1080             


Ala Cys  Asp Ser Asn Cys Gly  Ser Cys Asp Gln Asn  Gly Cys Tyr 
    1085                 1090                 1095             


Trp Cys  Glu Glu Gly Phe Phe  Leu Leu Gly Gly Ser  Cys Val Arg 
    1100                 1105                 1110             


Lys Cys  Gly Pro Gly Phe Tyr  Gly Asp Gln Glu Met  Gly Glu Cys 
    1115                 1120                 1125             


Glu Ser  Cys His Arg Ala Cys  Glu Thr Cys Thr Gly  Pro Gly His 
    1130                 1135                 1140             


Asp Glu  Cys Ser Ser Cys Gln  Glu Gly Leu Gln Leu  Leu Arg Gly 
    1145                 1150                 1155             


Met Cys  Val His Ala Thr Lys  Thr Gln Glu Glu Gly  Lys Phe Trp 
    1160                 1165                 1170             


Asn Asp  Ile Leu Arg Lys Leu  Gln Pro Cys His Ser  Ser Cys Lys 
    1175                 1180                 1185             


Thr Cys  Asn Gly Ser Ala Thr  Leu Cys Thr Ser Cys  Pro Lys Gly 
    1190                 1195                 1200             


Ala Tyr  Leu Leu Ala Gln Ala  Cys Val Ser Ser Cys  Pro Gln Gly 
    1205                 1210                 1215             


Thr Trp  Pro Ser Val Arg Ser  Gly Ser Cys Glu Asn  Cys Thr Glu 
    1220                 1225                 1230             


Ala Cys  Ala Ile Cys Ser Gly  Ala Asp Leu Cys Lys  Lys Cys Gln 
    1235                 1240                 1245             


Met Gln  Pro Gly His Pro Leu  Phe Leu His Glu Gly  Arg Cys Tyr 
    1250                 1255                 1260             


Ser Lys  Cys Pro Glu Gly Ser  Tyr Ala Glu Asp Gly  Ile Cys Glu 
    1265                 1270                 1275             


Arg Cys  Ser Ser Pro Cys Arg  Thr Cys Glu Gly Asn  Ala Thr Asn 
    1280                 1285                 1290             


Cys His  Ser Cys Glu Gly Gly  His Val Leu His His  Gly Val Cys 
    1295                 1300                 1305             


Gln Glu  Asn Cys Pro Glu Arg  His Val Ala Val Lys  Gly Val Cys 
    1310                 1315                 1320             


Lys His  Cys Pro Glu Met Cys  Gln Asp Cys Ile His  Glu Lys Thr 
    1325                 1330                 1335             


Cys Lys  Glu Cys Thr Pro Glu  Phe Phe Leu His Asp  Asp Met Cys 
    1340                 1345                 1350             


His Gln  Ser Cys Pro Arg Gly  Phe Tyr Ala Asp Ser  Arg His Cys 
    1355                 1360                 1365             


Val Pro  Cys His Lys Asp Cys  Leu Glu Cys Ser Gly  Pro Lys Ala 
    1370                 1375                 1380             


Asp Asp  Cys Glu Leu Cys Leu  Glu Ser Ser Trp Val  Leu Tyr Asp 
    1385                 1390                 1395             


Gly Leu  Cys Leu Glu Glu Cys  Pro Ala Gly Thr Tyr  Tyr Glu Lys 
    1400                 1405                 1410             


Glu Thr  Lys Glu Cys Arg Asp  Cys His Lys Ser Cys  Leu Thr Cys 
    1415                 1420                 1425             


Ser Ser  Ser Gly Thr Cys Thr  Thr Cys Gln Lys Gly  Leu Ile Met 
    1430                 1435                 1440             


Asn Pro  Arg Gly Ser Cys Met  Ala Asn Glu Lys Cys  Ser Pro Ser 
    1445                 1450                 1455             


Glu Tyr  Trp Asp Glu Asp Ala  Pro Gly Cys Lys Pro  Cys His Val 
    1460                 1465                 1470             


Lys Cys  Phe His Cys Met Gly  Pro Ala Glu Asp Gln  Cys Gln Thr 
    1475                 1480                 1485             


Cys Pro  Met Asn Ser Leu Leu  Leu Asn Thr Thr Cys  Val Lys Asp 
    1490                 1495                 1500             


Cys Pro  Glu Gly Tyr Tyr Ala  Asp Glu Asp Ser Asn  Arg Cys Ala 
    1505                 1510                 1515             


His Cys  His Ser Ser Cys Arg  Thr Cys Glu Gly Arg  His Ser Arg 
    1520                 1525                 1530             


Gln Cys  His Ser Cys Arg Pro  Gly Trp Phe Gln Leu  Gly Lys Glu 
    1535                 1540                 1545             


Cys Leu  Leu Gln Cys Arg Glu  Gly Tyr Tyr Ala Asp  Asn Ser Thr 
    1550                 1555                 1560             


Gly Arg  Cys Glu Arg Cys Asn  Arg Ser Cys Lys Gly  Cys Gln Gly 
    1565                 1570                 1575             


Pro Arg  Pro Thr Asp Cys Leu  Ser Cys Asp Arg Phe  Phe Phe Leu 
    1580                 1585                 1590             


Leu Arg  Ser Lys Gly Glu Cys  His Arg Ser Cys Pro  Asp His Tyr 
    1595                 1600                 1605             


Tyr Val  Glu Gln Ser Thr Gln  Thr Cys Glu Arg Cys  His Pro Thr 
    1610                 1615                 1620             


Cys Asp  Gln Cys Lys Gly Lys  Gly Ala Leu Asn Cys  Leu Ser Cys 
    1625                 1630                 1635             


Val Trp  Ser Tyr His Leu Met  Gly Gly Ile Cys Thr  Ser Asp Cys 
    1640                 1645                 1650             


Leu Val  Gly Glu Tyr Arg Val  Gly Glu Gly Glu Lys  Phe Asn Cys 
    1655                 1660                 1665             


Glu Lys  Cys His Glu Ser Cys  Met Glu Cys Lys Gly  Pro Gly Ala 
    1670                 1675                 1680             


Lys Asn  Cys Thr Leu Cys Pro  Ala Asn Leu Val Leu  His Met Asp 
    1685                 1690                 1695             


Asp Ser  His Cys Leu His Cys  Cys Asn Thr Ser Asp  Pro Pro Ser 
    1700                 1705                 1710             


Ala Gln  Glu Cys Cys Asp Cys  Gln Asp Thr Thr Asp  Glu Cys Ile 
    1715                 1720                 1725             


Leu Arg  Thr Ser Lys Val Arg  Pro Ala Thr Glu His  Phe Lys Thr 
    1730                 1735                 1740             


Ala Leu  Phe Ile Thr Ser Ser  Met Met Leu Val Leu  Leu Leu Gly 
    1745                 1750                 1755             


Ala Ala  Val Val Val Trp Lys  Lys Ser Arg Gly Arg  Val Gln Pro 
    1760                 1765                 1770             


Ala Ala  Lys Ala Gly Tyr Glu  Lys Leu Ala Asp Pro  Asn Lys Ser 
    1775                 1780                 1785             


Tyr Ser  Ser Tyr Lys Ser Ser  Tyr Arg Glu Ser Thr  Ser Phe Glu 
    1790                 1795                 1800             


Glu Asp  Gln Val Ile Glu Tyr  Arg Asp Arg Asp Tyr  Asp Glu Asp 
    1805                 1810                 1815             


Asp Asp  Asp Asp Ile Val Tyr  Met Gly Gln Asp Gly  Thr Val Tyr 
    1820                 1825                 1830             


Arg Lys  Phe Lys Tyr Gly Leu  Leu Asp Asp Asp Asp  Ile Asp Glu 
    1835                 1840                 1845             


Leu Glu  Tyr Asp Asp Glu Ser  Tyr Ser Tyr Tyr Gln  
    1850                 1855                 1860 


<210>  10129
<211>  1560
<212>  PRT
<213>  Homo Sapiens

<400>  10129

Asn Ser Ile Tyr Thr Ile Ser Ile Ser Ser Thr Ala Glu Ser Gly Lys 
1               5                   10                  15      


Lys Pro Trp Tyr Leu Glu Glu Cys Ser Ser Thr Leu Ala Thr Thr Tyr 
            20                  25                  30          


Ser Ser Gly Glu Ser Tyr Asp Lys Lys Ile Ile Thr Thr Asp Leu Arg 
        35                  40                  45              


Gln Arg Cys Thr Asp Asn His Thr Gly Thr Ser Ala Ser Ala Pro Met 
    50                  55                  60                  


Ala Ala Gly Ile Ile Ala Leu Ala Leu Glu Ala Asn Pro Phe Leu Thr 
65                  70                  75                  80  


Trp Arg Asp Val Gln His Val Ile Val Arg Thr Ser Arg Ala Gly His 
                85                  90                  95      


Leu Asn Ala Asn Asp Trp Lys Thr Asn Ala Ala Gly Phe Lys Val Ser 
            100                 105                 110         


His Leu Tyr Gly Phe Gly Leu Met Asp Ala Glu Ala Met Val Met Glu 
        115                 120                 125             


Ala Glu Lys Trp Thr Thr Val Pro Arg Gln His Val Cys Val Glu Ser 
    130                 135                 140                 


Thr Asp Arg Gln Ile Lys Thr Ile Arg Pro Asn Ser Ala Val Arg Ser 
145                 150                 155                 160 


Ile Tyr Lys Ala Ser Gly Cys Ser Asp Asn Pro Asn Arg His Val Asn 
                165                 170                 175     


Tyr Leu Glu His Val Val Val Arg Ile Thr Ile Thr His Pro Arg Arg 
            180                 185                 190         


Gly Asp Leu Ala Ile Tyr Leu Thr Ser Pro Ser Gly Thr Arg Ser Gln 
        195                 200                 205             


Leu Leu Ala Asn Arg Leu Phe Asp His Ser Met Glu Gly Phe Lys Asn 
    210                 215                 220                 


Trp Glu Phe Met Thr Ile His Cys Trp Gly Glu Arg Ala Ala Gly Asp 
225                 230                 235                 240 


Trp Val Leu Glu Val Tyr Asp Thr Pro Ser Gln Leu Arg Asn Phe Lys 
                245                 250                 255     


Thr Pro Gly Lys Leu Lys Glu Trp Ser Leu Val Leu Tyr Gly Thr Ser 
            260                 265                 270         


Val Gln Pro Tyr Ser Pro Thr Asn Glu Phe Pro Lys Val Glu Arg Phe 
        275                 280                 285             


Arg Tyr Ser Arg Val Glu Asp Pro Thr Asp Asp Tyr Gly Thr Glu Asp 
    290                 295                 300                 


Tyr Ala Gly Pro Cys Asp Pro Glu Cys Ser Glu Val Gly Cys Asp Gly 
305                 310                 315                 320 


Pro Gly Pro Asp His Cys Asn Asp Cys Leu His Tyr Tyr Tyr Lys Leu 
                325                 330                 335     


Lys Asn Asn Thr Arg Ile Cys Val Ser Ser Cys Pro Pro Gly His Tyr 
            340                 345                 350         


His Ala Asp Lys Lys Arg Cys Arg Lys Cys Ala Pro Asn Cys Glu Ser 
        355                 360                 365             


Cys Phe Gly Ser His Gly Asp Gln Cys Met Ser Cys Lys Tyr Gly Tyr 
    370                 375                 380                 


Phe Leu Asn Glu Glu Thr Asn Ser Cys Val Thr His Cys Pro Asp Gly 
385                 390                 395                 400 


Ser Tyr Gln Asp Thr Lys Lys Asn Leu Cys Arg Lys Cys Ser Glu Asn 
                405                 410                 415     


Cys Lys Thr Cys Thr Glu Phe His Asn Cys Thr Glu Cys Arg Asp Gly 
            420                 425                 430         


Leu Ser Leu Gln Gly Ser Arg Cys Ser Val Ser Cys Glu Asp Gly Arg 
        435                 440                 445             


Tyr Phe Asn Gly Gln Asp Cys Gln Pro Cys His Arg Phe Cys Ala Thr 
    450                 455                 460                 


Cys Ala Gly Ala Gly Ala Asp Gly Cys Ile Asn Cys Thr Glu Gly Tyr 
465                 470                 475                 480 


Phe Met Glu Asp Gly Arg Cys Val Gln Ser Cys Ser Ile Ser Tyr Tyr 
                485                 490                 495     


Phe Asp His Ser Ser Glu Asn Gly Tyr Lys Ser Cys Lys Lys Cys Asp 
            500                 505                 510         


Ile Ser Cys Leu Thr Cys Asn Gly Pro Gly Phe Lys Asn Cys Thr Ser 
        515                 520                 525             


Cys Pro Ser Gly Tyr Leu Leu Asp Leu Gly Met Cys Gln Met Gly Ala 
    530                 535                 540                 


Ile Cys Lys Asp Gly Glu Tyr Val Asp Glu His Gly His Cys Gln Thr 
545                 550                 555                 560 


Cys Glu Ala Ser Cys Ala Lys Cys Gln Gly Pro Thr Gln Glu Asp Cys 
                565                 570                 575     


Thr Thr Cys Pro Met Thr Arg Ile Phe Asp Asp Gly Arg Cys Val Ser 
            580                 585                 590         


Asn Cys Pro Ser Trp Lys Phe Glu Phe Glu Asn Gln Cys His Pro Cys 
        595                 600                 605             


His His Thr Cys Gln Arg Cys Gln Gly Ser Gly Pro Thr His Cys Thr 
    610                 615                 620                 


Ser Cys Gly Ala Asp Asn Tyr Gly Arg Glu His Phe Leu Tyr Gln Gly 
625                 630                 635                 640 


Glu Cys Gly Asp Ser Cys Pro Glu Gly His Tyr Ala Thr Glu Gly Asn 
                645                 650                 655     


Thr Cys Leu Pro Cys Pro Asp Asn Cys Glu Leu Cys His Ser Val His 
            660                 665                 670         


Val Cys Thr Arg Cys Met Lys Gly Tyr Phe Ile Ala Pro Thr Asn His 
        675                 680                 685             


Thr Cys Gln Lys Leu Glu Cys Gly Gln Gly Glu Val Gln Asp Pro Asp 
    690                 695                 700                 


Tyr Glu Glu Cys Val Pro Cys Glu Glu Gly Cys Leu Gly Cys Ser Leu 
705                 710                 715                 720 


Asp Asp Pro Gly Thr Cys Thr Ser Cys Ala Met Gly Tyr Tyr Arg Phe 
                725                 730                 735     


Asp His His Cys Tyr Lys Thr Cys Pro Glu Lys Thr Tyr Ser Glu Glu 
            740                 745                 750         


Val Glu Cys Lys Ala Cys Asp Ser Asn Cys Gly Ser Cys Asp Gln Asn 
        755                 760                 765             


Gly Cys Tyr Trp Cys Glu Glu Gly Phe Phe Leu Leu Gly Gly Ser Cys 
    770                 775                 780                 


Val Arg Lys Cys Gly Pro Gly Phe Tyr Gly Asp Gln Glu Met Gly Glu 
785                 790                 795                 800 


Cys Glu Ser Cys His Arg Ala Cys Glu Thr Cys Thr Gly Pro Gly His 
                805                 810                 815     


Asp Glu Cys Ser Ser Cys Gln Glu Gly Leu Gln Leu Leu Arg Gly Met 
            820                 825                 830         


Cys Val His Ala Thr Lys Thr Gln Glu Glu Gly Lys Phe Trp Asn Glu 
        835                 840                 845             


Ala Val Ser Thr Ala Asn Leu Ser Val Val Lys Ser Leu Leu Gln Glu 
    850                 855                 860                 


Arg Arg Arg Trp Lys Val Gln Ile Lys Arg Asp Ile Leu Arg Lys Leu 
865                 870                 875                 880 


Gln Pro Cys His Ser Ser Cys Lys Thr Cys Asn Gly Ser Ala Thr Leu 
                885                 890                 895     


Cys Thr Ser Cys Pro Lys Gly Ala Tyr Leu Leu Ala Gln Ala Cys Val 
            900                 905                 910         


Ser Ser Cys Pro Gln Gly Thr Trp Pro Ser Val Arg Ser Gly Ser Cys 
        915                 920                 925             


Glu Asn Cys Thr Glu Ala Cys Ala Ile Cys Ser Gly Ala Asp Leu Cys 
    930                 935                 940                 


Lys Lys Cys Gln Met Gln Pro Gly His Pro Leu Phe Leu His Glu Gly 
945                 950                 955                 960 


Arg Cys Tyr Ser Lys Cys Pro Glu Gly Ser Tyr Ala Glu Asp Gly Ile 
                965                 970                 975     


Cys Glu Arg Cys Ser Ser Pro Cys Arg Thr Cys Glu Gly Asn Ala Thr 
            980                 985                 990         


Asn Cys His Ser Cys Glu Gly Gly  His Val Leu His His  Gly Val Cys 
        995                 1000                 1005             


Gln Glu  Asn Cys Pro Glu Arg  His Val Ala Val Lys  Gly Val Cys 
    1010                 1015                 1020             


Lys His  Cys Pro Glu Met Cys  Gln Asp Cys Ile His  Glu Lys Thr 
    1025                 1030                 1035             


Cys Lys  Glu Cys Thr Pro Glu  Phe Phe Leu His Asp  Asp Met Cys 
    1040                 1045                 1050             


His Gln  Ser Cys Pro Arg Gly  Phe Tyr Ala Asp Ser  Arg His Cys 
    1055                 1060                 1065             


Val Pro  Cys His Lys Asp Cys  Leu Glu Cys Ser Gly  Pro Lys Ala 
    1070                 1075                 1080             


Asp Asp  Cys Glu Leu Cys Leu  Glu Ser Ser Trp Val  Leu Tyr Asp 
    1085                 1090                 1095             


Gly Leu  Cys Leu Glu Glu Cys  Pro Ala Gly Thr Tyr  Tyr Glu Lys 
    1100                 1105                 1110             


Glu Thr  Lys Glu Cys Arg Asp  Cys His Lys Ser Cys  Leu Thr Cys 
    1115                 1120                 1125             


Ser Ser  Ser Gly Thr Cys Thr  Thr Cys Gln Lys Gly  Leu Ile Met 
    1130                 1135                 1140             


Asn Pro  Arg Gly Ser Cys Met  Ala Asn Glu Lys Cys  Ser Pro Ser 
    1145                 1150                 1155             


Glu Tyr  Trp Asp Glu Asp Ala  Pro Gly Cys Lys Pro  Cys His Val 
    1160                 1165                 1170             


Lys Cys  Phe His Cys Met Gly  Pro Ala Glu Asp Gln  Cys Gln Thr 
    1175                 1180                 1185             


Cys Pro  Met Asn Ser Leu Leu  Leu Asn Thr Thr Cys  Val Lys Asp 
    1190                 1195                 1200             


Cys Pro  Glu Gly Tyr Tyr Ala  Asp Glu Asp Ser Asn  Arg Cys Ala 
    1205                 1210                 1215             


His Cys  His Ser Ser Cys Arg  Thr Cys Glu Gly Arg  His Ser Arg 
    1220                 1225                 1230             


Gln Cys  His Ser Cys Arg Pro  Gly Trp Phe Gln Leu  Gly Lys Glu 
    1235                 1240                 1245             


Cys Leu  Leu Gln Cys Arg Glu  Gly Tyr Tyr Ala Asp  Asn Ser Thr 
    1250                 1255                 1260             


Gly Arg  Cys Glu Arg Cys Asn  Arg Ser Cys Lys Gly  Cys Gln Gly 
    1265                 1270                 1275             


Pro Arg  Pro Thr Asp Cys Leu  Ser Cys Asp Arg Phe  Phe Phe Leu 
    1280                 1285                 1290             


Leu Arg  Ser Lys Gly Glu Cys  His Arg Ser Cys Pro  Asp His Tyr 
    1295                 1300                 1305             


Tyr Val  Glu Gln Ser Thr Gln  Thr Cys Glu Arg Cys  His Pro Thr 
    1310                 1315                 1320             


Cys Asp  Gln Cys Lys Gly Lys  Gly Ala Leu Asn Cys  Leu Ser Cys 
    1325                 1330                 1335             


Val Trp  Ser Tyr His Leu Met  Gly Gly Ile Cys Thr  Ser Asp Cys 
    1340                 1345                 1350             


Leu Val  Gly Glu Tyr Arg Val  Gly Glu Gly Glu Lys  Phe Asn Cys 
    1355                 1360                 1365             


Glu Lys  Cys His Glu Ser Cys  Met Glu Cys Lys Gly  Pro Gly Ala 
    1370                 1375                 1380             


Lys Asn  Cys Thr Leu Cys Pro  Ala Asn Leu Val Leu  His Met Asp 
    1385                 1390                 1395             


Asp Ser  His Cys Leu His Cys  Cys Asn Thr Ser Asp  Pro Pro Ser 
    1400                 1405                 1410             


Ala Gln  Glu Cys Cys Asp Cys  Gln Asp Thr Thr Asp  Glu Cys Ile 
    1415                 1420                 1425             


Leu Arg  Thr Ser Lys Val Arg  Pro Ala Thr Glu His  Phe Lys Thr 
    1430                 1435                 1440             


Ala Leu  Phe Ile Thr Ser Ser  Met Met Leu Val Leu  Leu Leu Gly 
    1445                 1450                 1455             


Ala Ala  Val Val Val Trp Lys  Lys Ser Arg Gly Arg  Val Gln Pro 
    1460                 1465                 1470             


Ala Ala  Lys Ala Gly Tyr Glu  Lys Leu Ala Asp Pro  Asn Lys Ser 
    1475                 1480                 1485             


Tyr Ser  Ser Tyr Lys Ser Ser  Tyr Arg Glu Ser Thr  Ser Phe Glu 
    1490                 1495                 1500             


Glu Asp  Gln Val Ile Glu Tyr  Arg Asp Arg Asp Tyr  Asp Glu Asp 
    1505                 1510                 1515             


Asp Asp  Asp Asp Ile Val Tyr  Met Gly Gln Asp Gly  Thr Val Tyr 
    1520                 1525                 1530             


Arg Lys  Phe Lys Tyr Gly Leu  Leu Asp Asp Asp Asp  Ile Asp Glu 
    1535                 1540                 1545             


Leu Glu  Tyr Asp Asp Glu Ser  Tyr Ser Tyr Tyr Gln  
    1550                 1555                 1560 


<210>  10130
<211>  692
<212>  PRT
<213>  Homo Sapiens

<400>  10130

Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu 
            20                  25                  30          


Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser Glu 
        35                  40                  45              


Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala Thr Phe 
    50                  55                  60                  


His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val 
65                  70                  75                  80  


Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr Ala Arg 
                85                  90                  95      


Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu 
            100                 105                 110         


His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met Ser Gly 
        115                 120                 125             


Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile Glu 
    130                 135                 140                 


Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg 
145                 150                 155                 160 


Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly 
                165                 170                 175     


Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp 
            180                 185                 190         


His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn Val 
        195                 200                 205             


Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp 
    210                 215                 220                 


Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly 
225                 230                 235                 240 


Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn Cys Gln 
                245                 250                 255     


Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg 
            260                 265                 270         


Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu Pro 
        275                 280                 285             


Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln Arg Leu 
    290                 295                 300                 


Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp 
305                 310                 315                 320 


Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val 
                325                 330                 335     


Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly 
            340                 345                 350         


Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile 
        355                 360                 365             


Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln Ser Gly 
    370                 375                 380                 


Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met Leu 
385                 390                 395                 400 


Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile 
                405                 410                 415     


His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro Glu Asp 
            420                 425                 430         


Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro Ser Thr 
        435                 440                 445             


His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala His 
    450                 455                 460                 


Ser Gly Pro Thr Arg Met Ala Thr Ala Val Ala Arg Cys Ala Pro Asp 
465                 470                 475                 480 


Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys Arg Arg 
                485                 490                 495     


Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg Ala His 
            500                 505                 510         


Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys Cys Leu 
        515                 520                 525             


Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala Glu Ala 
    530                 535                 540                 


Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val Leu Thr 
545                 550                 555                 560 


Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His Lys Pro 
                565                 570                 575     


Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly His Arg 
            580                 585                 590         


Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu Glu Cys 
        595                 600                 605             


Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val Thr Val 
    610                 615                 620                 


Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu Pro Gly 
625                 630                 635                 640 


Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys Val Val 
                645                 650                 655     


Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Gly Ala Val 
            660                 665                 670         


Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln Ala Ser 
        675                 680                 685             


Gln Glu Leu Gln 
    690         


<210>  10131
<211>  293
<212>  PRT
<213>  Homo Sapiens

<400>  10131

Met Gly Arg Val Val Ala Glu Leu Val Ser Ser Leu Leu Gly Leu Trp 
1               5                   10                  15      


Leu Leu Leu Cys Ser Cys Gly Cys Pro Glu Gly Ala Glu Leu Arg Ala 
            20                  25                  30          


Pro Pro Asp Lys Ile Ala Ile Ile Gly Ala Gly Ile Gly Gly Thr Ser 
        35                  40                  45              


Ala Ala Tyr Tyr Leu Arg Gln Lys Phe Gly Lys Asp Val Lys Ile Asp 
    50                  55                  60                  


Leu Phe Glu Arg Glu Glu Val Gly Gly Arg Leu Ala Thr Met Met Val 
65                  70                  75                  80  


Gln Gly Gln Glu Tyr Glu Ala Gly Gly Ser Val Ile His Pro Leu Asn 
                85                  90                  95      


Leu His Met Lys Arg Phe Val Lys Asp Leu Gly Leu Ser Ala Val Gln 
            100                 105                 110         


Ala Ser Gly Gly Leu Leu Gly Ile Tyr Asn Gly Glu Thr Leu Val Phe 
        115                 120                 125             


Glu Glu Ser Asn Trp Phe Ile Ile Asn Val Ile Lys Leu Val Trp Arg 
    130                 135                 140                 


Tyr Gly Phe Gln Ser Leu Arg Met His Met Trp Val Glu Asp Val Leu 
145                 150                 155                 160 


Asp Lys Phe Met Arg Ile Tyr Arg Tyr Gln Ser His Asp Tyr Ala Phe 
                165                 170                 175     


Ser Ser Val Glu Lys Leu Leu His Ala Leu Gly Gly Asp Asp Phe Leu 
            180                 185                 190         


Gly Met Leu Asn Arg Thr Leu Leu Glu Thr Leu Gln Lys Ala Gly Phe 
        195                 200                 205             


Ser Glu Lys Phe Leu Asn Glu Met Ile Ala Pro Val Met Arg Val Asn 
    210                 215                 220                 


Tyr Gly Gln Ser Thr Asp Ile Asn Ala Phe Val Gly Ala Val Ser Leu 
225                 230                 235                 240 


Ser Cys Ser Asp Ser Gly Leu Trp Ala Val Glu Gly Gly Asn Lys Leu 
                245                 250                 255     


Val Cys Ser Gly Leu Leu Gln Ala Ser Lys Ser Asn Leu Ile Ser Gly 
            260                 265                 270         


Ser Val Met Tyr Ile Glu Glu Lys Thr Lys Thr Lys Tyr Thr Val Leu 
        275                 280                 285             


Gly Leu Cys Pro Leu 
    290             


<210>  10132
<211>  505
<212>  PRT
<213>  Homo Sapiens

<400>  10132

Met Gly Arg Val Val Ala Glu Leu Val Ser Ser Leu Leu Gly Leu Trp 
1               5                   10                  15      


Leu Leu Leu Cys Ser Cys Gly Cys Pro Glu Gly Ala Glu Leu Arg Ala 
            20                  25                  30          


Pro Pro Asp Lys Ile Ala Ile Ile Gly Ala Gly Ile Gly Gly Thr Ser 
        35                  40                  45              


Ala Ala Tyr Tyr Leu Arg Gln Lys Phe Gly Lys Asp Val Lys Ile Asp 
    50                  55                  60                  


Leu Phe Glu Arg Glu Glu Val Gly Gly Arg Leu Ala Thr Met Met Val 
65                  70                  75                  80  


Gln Gly Gln Glu Tyr Glu Ala Gly Gly Ser Val Ile His Pro Leu Asn 
                85                  90                  95      


Leu His Met Lys Arg Phe Val Lys Asp Leu Gly Leu Ser Ala Val Gln 
            100                 105                 110         


Ala Ser Gly Gly Leu Leu Gly Ile Tyr Asn Gly Glu Thr Leu Val Phe 
        115                 120                 125             


Glu Glu Ser Asn Trp Phe Ile Ile Asn Val Ile Lys Leu Val Trp Arg 
    130                 135                 140                 


Tyr Gly Phe Gln Ser Leu Arg Met His Met Trp Val Glu Asp Val Leu 
145                 150                 155                 160 


Asp Lys Phe Met Arg Ile Tyr Arg Tyr Gln Ser His Asp Tyr Ala Phe 
                165                 170                 175     


Ser Ser Val Glu Lys Leu Leu His Ala Leu Gly Gly Asp Asp Phe Leu 
            180                 185                 190         


Gly Met Leu Asn Arg Thr Leu Leu Glu Thr Leu Gln Lys Ala Gly Phe 
        195                 200                 205             


Ser Glu Lys Phe Leu Asn Glu Met Ile Ala Pro Val Met Arg Val Asn 
    210                 215                 220                 


Tyr Gly Gln Ser Thr Asp Ile Asn Ala Phe Val Gly Ala Val Ser Leu 
225                 230                 235                 240 


Ser Cys Ser Asp Ser Gly Leu Trp Ala Val Glu Gly Gly Asn Lys Leu 
                245                 250                 255     


Val Cys Ser Gly Leu Leu Gln Ala Ser Lys Ser Asn Leu Ile Ser Gly 
            260                 265                 270         


Ser Val Met Tyr Ile Glu Glu Lys Thr Lys Thr Lys Tyr Thr Gly Asn 
        275                 280                 285             


Pro Thr Lys Met Tyr Glu Val Val Tyr Gln Ile Gly Thr Glu Thr Arg 
    290                 295                 300                 


Ser Asp Phe Tyr Asp Ile Val Leu Val Ala Thr Pro Leu Asn Arg Lys 
305                 310                 315                 320 


Met Ser Asn Ile Thr Phe Leu Asn Phe Asp Pro Pro Ile Glu Glu Phe 
                325                 330                 335     


His Gln Tyr Tyr Gln His Ile Val Thr Thr Leu Val Lys Gly Glu Leu 
            340                 345                 350         


Asn Thr Ser Ile Phe Ser Ser Arg Pro Ile Asp Lys Phe Gly Leu Asn 
        355                 360                 365             


Thr Val Leu Thr Thr Asp Asn Ser Asp Leu Phe Ile Asn Ser Ile Gly 
    370                 375                 380                 


Ile Val Pro Ser Val Arg Glu Lys Glu Asp Pro Glu Pro Ser Thr Asp 
385                 390                 395                 400 


Gly Thr Tyr Val Trp Lys Ile Phe Ser Gln Glu Thr Leu Thr Lys Ala 
                405                 410                 415     


Gln Ile Leu Lys Leu Phe Leu Ser Tyr Asp Tyr Ala Val Lys Lys Pro 
            420                 425                 430         


Trp Leu Ala Tyr Pro His Tyr Lys Pro Pro Glu Lys Cys Pro Ser Ile 
        435                 440                 445             


Ile Leu His Asp Arg Leu Tyr Tyr Leu Asn Gly Ile Glu Cys Ala Ala 
    450                 455                 460                 


Ser Ala Met Glu Met Ser Ala Ile Ala Ala His Asn Ala Ala Leu Leu 
465                 470                 475                 480 


Ala Tyr His Arg Trp Asn Gly His Thr Asp Met Ile Asp Gln Asp Gly 
                485                 490                 495     


Leu Tyr Glu Lys Leu Lys Thr Glu Leu 
            500                 505 


<210>  10133
<211>  130
<212>  PRT
<213>  Homo Sapiens

<400>  10133

Met Met Val Gln Gly Gln Glu Tyr Glu Ala Gly Gly Ser Val Ile His 
1               5                   10                  15      


Pro Leu Asn Leu His Met Lys Arg Phe Val Lys Asp Leu Gly Leu Ser 
            20                  25                  30          


Ala Val Gln Ala Ser Gly Gly Leu Leu Gly Ile Tyr Asn Gly Glu Thr 
        35                  40                  45              


Leu Val Phe Glu Glu Ser Asn Trp Phe Ile Ile Asn Val Ile Lys Leu 
    50                  55                  60                  


Val Trp Arg Tyr Gly Phe Gln Ser Leu Arg Met His Met Trp Val Glu 
65                  70                  75                  80  


Asp Val Leu Asp Lys Phe Met Arg Ile Tyr Arg Tyr Gln Ser His Asp 
                85                  90                  95      


Tyr Ala Phe Ser Ser Val Glu Lys Leu Leu His Ala Leu Gly Gly Asp 
            100                 105                 110         


Asp Phe Leu Gly Met Leu Asn Arg Thr Leu Leu Glu Thr Leu Gln Lys 
        115                 120                 125             


Ala Gly 
    130 


<210>  10134
<211>  154
<212>  PRT
<213>  Homo Sapiens

<400>  10134

Met Met Val Gln Gly Gln Glu Tyr Glu Ala Gly Gly Ser Val Ile His 
1               5                   10                  15      


Pro Leu Asn Leu His Met Lys Arg Phe Val Lys Asp Leu Gly Leu Ser 
            20                  25                  30          


Ala Val Gln Ala Ser Gly Gly Leu Leu Gly Ile Tyr Asn Gly Glu Thr 
        35                  40                  45              


Leu Val Phe Glu Glu Ser Asn Trp Phe Ile Ile Asn Val Ile Lys Leu 
    50                  55                  60                  


Val Trp Arg Tyr Gly Phe Gln Ser Leu Arg Met His Met Trp Val Glu 
65                  70                  75                  80  


Asp Val Leu Asp Lys Phe Met Arg Ile Tyr Arg Tyr Gln Ser His Asp 
                85                  90                  95      


Tyr Ala Phe Ser Ser Val Glu Lys Leu Leu His Ala Leu Gly Gly Asp 
            100                 105                 110         


Asp Phe Leu Gly Met Leu Asn Arg Thr Leu Leu Glu Thr Leu Gln Lys 
        115                 120                 125             


Ala Gly Phe Ser Glu Lys Phe Leu Asn Glu Met Ile Ala Pro Val Met 
    130                 135                 140                 


Arg Val Asn Tyr Gly Gln Ser Thr Asp Ile 
145                 150                 


<210>  10135
<211>  209
<212>  PRT
<213>  Homo Sapiens

<400>  10135

Met Met Val Gln Gly Gln Glu Tyr Glu Ala Gly Gly Ser Val Ile His 
1               5                   10                  15      


Pro Leu Asn Leu His Met Lys Arg Phe Val Lys Asp Leu Gly Leu Ser 
            20                  25                  30          


Ala Val Gln Ala Ser Gly Gly Leu Leu Gly Ile Tyr Asn Gly Glu Thr 
        35                  40                  45              


Leu Val Phe Glu Glu Ser Asn Trp Phe Ile Ile Asn Val Ile Lys Leu 
    50                  55                  60                  


Val Trp Arg Tyr Gly Phe Gln Ser Leu Arg Met His Met Trp Val Glu 
65                  70                  75                  80  


Asp Val Leu Asp Lys Phe Met Arg Ile Tyr Arg Tyr Gln Ser His Asp 
                85                  90                  95      


Tyr Ala Phe Ser Ser Val Glu Lys Leu Leu His Ala Leu Gly Gly Asp 
            100                 105                 110         


Asp Phe Leu Gly Met Leu Asn Arg Thr Leu Leu Glu Thr Leu Gln Lys 
        115                 120                 125             


Ala Gly Phe Ser Glu Lys Phe Leu Asn Glu Met Ile Ala Pro Val Met 
    130                 135                 140                 


Arg Val Asn Tyr Gly Gln Ser Thr Asp Ile Asn Ala Phe Val Gly Ala 
145                 150                 155                 160 


Val Ser Leu Ser Cys Ser Asp Ser Gly Leu Trp Ala Val Glu Gly Gly 
                165                 170                 175     


Asn Lys Leu Val Cys Ser Gly Leu Leu Gln Ala Ser Lys Ser Asn Leu 
            180                 185                 190         


Ile Ser Gly Ser Val Met Tyr Ile Glu Glu Lys Thr Lys Thr Lys Tyr 
        195                 200                 205             


Thr 
    


<210>  10136
<211>  111
<212>  PRT
<213>  Homo Sapiens

<400>  10136

Met Ala Arg Ala Ala Pro Leu Leu Ala Ala Leu Thr Ala Leu Leu Ala 
1               5                   10                  15      


Ala Ala Ala Ala Gly Gly Asp Ala Pro Pro Gly Lys Ile Ala Val Val 
            20                  25                  30          


Gly Ala Gly Ile Gly Gly Ser Ala Val Ala His Phe Leu Gln Gln His 
        35                  40                  45              


Phe Gly Pro Arg Val Gln Ile Asp Val Tyr Glu Lys Gly Thr Val Gly 
    50                  55                  60                  


Gly Arg Leu Ala Thr Ile Ser Val Asn Lys Gln His Tyr Glu Ser Gly 
65                  70                  75                  80  


Ala Ala Ser Phe His Ser Leu Ser Leu His Met Gln Asp Phe Val Lys 
                85                  90                  95      


Leu Leu Asp Gly Ala Thr Glu Thr Arg Glu Gly Lys Glu Leu Ala 
            100                 105                 110     


<210>  10137
<211>  494
<212>  PRT
<213>  Homo Sapiens

<400>  10137

Met Ala Arg Ala Ala Pro Leu Leu Ala Ala Leu Thr Ala Leu Leu Ala 
1               5                   10                  15      


Ala Ala Ala Ala Gly Gly Asp Ala Pro Pro Gly Lys Ile Ala Val Val 
            20                  25                  30          


Gly Ala Gly Ile Gly Gly Ser Ala Val Ala His Phe Leu Gln Gln His 
        35                  40                  45              


Phe Gly Pro Arg Val Gln Ile Asp Val Tyr Glu Lys Gly Thr Val Gly 
    50                  55                  60                  


Gly Arg Leu Ala Thr Ile Ser Val Asn Lys Gln His Tyr Glu Ser Gly 
65                  70                  75                  80  


Ala Ala Ser Phe His Ser Leu Ser Leu His Met Gln Asp Phe Val Lys 
                85                  90                  95      


Leu Leu Gly Leu Arg His Arg Arg Glu Val Val Gly Arg Ser Ala Ile 
            100                 105                 110         


Phe Gly Gly Glu His Phe Met Leu Glu Glu Thr Asp Trp Tyr Leu Leu 
        115                 120                 125             


Asn Leu Phe Arg Leu Trp Trp His Tyr Gly Ile Ser Phe Leu Arg Leu 
    130                 135                 140                 


Gln Met Trp Val Glu Glu Val Met Glu Lys Phe Met Arg Ile Tyr Lys 
145                 150                 155                 160 


Tyr Gln Ala His Gly Tyr Ala Phe Ser Gly Val Glu Glu Leu Leu Tyr 
                165                 170                 175     


Ser Leu Gly Glu Ser Thr Phe Val Asn Met Thr Gln His Ser Val Ala 
            180                 185                 190         


Glu Ser Leu Leu Gln Val Gly Val Thr Gln Arg Phe Ile Asp Asp Val 
        195                 200                 205             


Val Ser Ala Val Leu Arg Ala Ser Tyr Gly Gln Ser Ala Ala Met Pro 
    210                 215                 220                 


Ala Phe Ala Gly Ala Met Ser Leu Ala Gly Ala Gln Gly Ser Leu Trp 
225                 230                 235                 240 


Ser Val Glu Gly Gly Asn Lys Leu Val Cys Ser Gly Leu Leu Lys Leu 
                245                 250                 255     


Thr Lys Ala Asn Val Ile His Ala Thr Val Thr Ser Val Thr Leu His 
            260                 265                 270         


Ser Thr Glu Gly Lys Ala Leu Tyr Gln Val Ala Tyr Glu Asn Glu Val 
        275                 280                 285             


Gly Asn Ser Ser Asp Phe Tyr Asp Ile Val Val Ile Ala Thr Pro Leu 
    290                 295                 300                 


His Leu Asp Asn Ser Ser Ser Asn Leu Thr Phe Ala Gly Phe His Pro 
305                 310                 315                 320 


Pro Ile Asp Asp Val Gln Gly Ser Phe Gln Pro Thr Val Val Ser Leu 
                325                 330                 335     


Val His Gly Tyr Leu Asn Ser Ser Tyr Phe Gly Phe Pro Asp Pro Lys 
            340                 345                 350         


Leu Phe Pro Phe Ala Asn Ile Leu Thr Thr Asp Phe Pro Ser Phe Phe 
        355                 360                 365             


Cys Thr Leu Asp Asn Ile Cys Pro Val Asn Ile Ser Ala Ser Phe Arg 
    370                 375                 380                 


Arg Lys Gln Pro Gln Glu Ala Ala Val Trp Arg Val Gln Ser Pro Lys 
385                 390                 395                 400 


Pro Leu Phe Arg Thr Gln Leu Lys Thr Leu Phe Arg Ser Tyr Tyr Ser 
                405                 410                 415     


Val Gln Thr Ala Glu Trp Gln Ala His Pro Leu Tyr Gly Ser Arg Pro 
            420                 425                 430         


Thr Leu Pro Arg Phe Ala Leu His Asp Gln Leu Phe Tyr Leu Asn Ala 
        435                 440                 445             


Leu Glu Trp Ala Ala Ser Ser Val Glu Val Met Ala Val Ala Ala Lys 
    450                 455                 460                 


Asn Val Ala Leu Leu Ala Tyr Asn Arg Trp Tyr Gln Asp Leu Asp Lys 
465                 470                 475                 480 


Ile Asp Gln Lys Asp Leu Met His Lys Val Lys Thr Glu Leu 
                485                 490                 


<210>  10138
<211>  82
<212>  PRT
<213>  Homo Sapiens

<400>  10138

Met Ala Arg Ala Ala Pro Leu Leu Ala Ala Leu Thr Ala Leu Leu Ala 
1               5                   10                  15      


Ala Ala Ala Ala Gly Gly Asp Ala Pro Pro Gly Lys Ile Gly Ala Gly 
            20                  25                  30          


Arg Thr Arg Gly Gly Trp Gly Trp Asp Trp Gly Leu Cys Cys Gly Pro 
        35                  40                  45              


Phe Ser Pro Ala Ala Leu Trp Thr Ser Gly Ala Asp Arg Arg Val Arg 
    50                  55                  60                  


Glu Gly Asn Arg Gly Trp Pro Leu Gly His His Leu Ser Gln Gln Ala 
65                  70                  75                  80  


Ala Leu 
        


<210>  10139
<211>  82
<212>  PRT
<213>  Homo Sapiens

<400>  10139

Met Ala Arg Ala Ala Pro Leu Leu Ala Ala Leu Thr Ala Leu Leu Ala 
1               5                   10                  15      


Ala Ala Ala Ala Gly Gly Asp Ala Pro Pro Gly Lys Ile Gly Ala Gly 
            20                  25                  30          


Arg Thr Arg Gly Gly Trp Gly Trp Asp Trp Gly Leu Cys Cys Gly Pro 
        35                  40                  45              


Phe Ser Pro Ala Ala Leu Trp Thr Ser Gly Ala Asp Arg Arg Val Arg 
    50                  55                  60                  


Glu Gly Asn Arg Gly Trp Pro Leu Gly His His Leu Ser Gln Gln Ala 
65                  70                  75                  80  


Ala Leu 
        


<210>  10140
<211>  404
<212>  PRT
<213>  Homo Sapiens

<400>  10140

Met Gln Asp Phe Val Lys Leu Leu Gly Leu Arg His Arg Arg Glu Val 
1               5                   10                  15      


Val Gly Arg Ser Ala Ile Phe Gly Gly Glu His Phe Met Leu Glu Glu 
            20                  25                  30          


Thr Asp Trp Tyr Leu Leu Asn Leu Phe Arg Leu Trp Trp His Tyr Gly 
        35                  40                  45              


Ile Ser Phe Leu Arg Leu Gln Met Trp Val Glu Glu Val Met Glu Lys 
    50                  55                  60                  


Phe Met Arg Ile Tyr Lys Tyr Gln Ala His Gly Tyr Ala Phe Ser Gly 
65                  70                  75                  80  


Val Glu Glu Leu Leu Tyr Ser Leu Gly Glu Ser Thr Phe Val Asn Met 
                85                  90                  95      


Thr Gln His Ser Val Ala Glu Ser Leu Leu Gln Val Gly Val Thr Gln 
            100                 105                 110         


Arg Phe Ile Asp Asp Val Val Ser Ala Val Leu Arg Ala Ser Tyr Gly 
        115                 120                 125             


Gln Ser Ala Ala Met Pro Ala Phe Ala Gly Ala Met Ser Leu Ala Gly 
    130                 135                 140                 


Ala Gln Gly Ser Leu Trp Ser Val Glu Gly Gly Asn Lys Leu Val Cys 
145                 150                 155                 160 


Ser Gly Leu Leu Lys Leu Thr Lys Ala Asn Val Ile His Ala Thr Val 
                165                 170                 175     


Thr Ser Val Thr Leu His Ser Thr Glu Gly Lys Ala Leu Tyr Gln Val 
            180                 185                 190         


Ala Tyr Glu Asn Glu Val Gly Asn Ser Ser Asp Phe Tyr Asp Ile Val 
        195                 200                 205             


Val Ile Ala Thr Pro Leu His Leu Asp Asn Ser Ser Ser Asn Leu Thr 
    210                 215                 220                 


Phe Ala Gly Phe His Pro Pro Ile Asp Asp Val Gln Gly Ser Phe Gln 
225                 230                 235                 240 


Pro Thr Val Val Ser Leu Val His Gly Tyr Leu Asn Ser Ser Tyr Phe 
                245                 250                 255     


Gly Phe Pro Asp Pro Lys Leu Phe Pro Phe Ala Asn Ile Leu Thr Thr 
            260                 265                 270         


Asp Phe Pro Ser Phe Phe Cys Thr Leu Asp Asn Ile Cys Pro Val Asn 
        275                 280                 285             


Ile Ser Ala Ser Phe Arg Arg Lys Gln Pro Gln Glu Ala Ala Val Trp 
    290                 295                 300                 


Arg Val Gln Ser Pro Lys Pro Leu Phe Arg Thr Gln Leu Lys Thr Leu 
305                 310                 315                 320 


Phe Arg Ser Tyr Tyr Ser Val Gln Thr Ala Glu Trp Gln Ala His Pro 
                325                 330                 335     


Leu Tyr Gly Ser Arg Pro Thr Leu Pro Arg Phe Ala Leu His Asp Gln 
            340                 345                 350         


Leu Phe Tyr Leu Asn Ala Leu Glu Trp Ala Ala Ser Ser Val Glu Val 
        355                 360                 365             


Met Ala Val Ala Ala Lys Asn Val Ala Leu Leu Ala Tyr Asn Arg Trp 
    370                 375                 380                 


Tyr Gln Asp Leu Asp Lys Ile Asp Gln Lys Asp Leu Met His Lys Val 
385                 390                 395                 400 


Lys Thr Glu Leu 
                


<210>  10141
<211>  933
<212>  PRT
<213>  Homo Sapiens

<400>  10141

Met Ala Ala Ser Arg Leu Asp Phe Gly Glu Val Glu Thr Phe Leu Asp 
1               5                   10                  15      


Arg His Pro Glu Leu Phe Glu Asp Tyr Leu Met Arg Lys Gly Lys Gln 
            20                  25                  30          


Glu Met Val Glu Lys Trp Leu Gln Arg His Ser Gln Gly Gln Gly Ala 
        35                  40                  45              


Leu Gly Pro Arg Pro Ser Leu Ala Gly Thr Ser Ser Leu Ala His Ser 
    50                  55                  60                  


Thr Cys Arg Gly Gly Ser Ser Val Gly Gly Gly Thr Gly Pro Asn Gly 
65                  70                  75                  80  


Ser Ala His Ser Gln Pro Leu Pro Gly Gly Gly Asp Cys Gly Gly Val 
                85                  90                  95      


Pro Leu Ser Pro Ser Trp Ala Gly Gly Ser Arg Gly Asp Gly Asn Leu 
            100                 105                 110         


Gln Arg Arg Ala Ser Gln Lys Glu Leu Arg Lys Ser Phe Ala Arg Ser 
        115                 120                 125             


Lys Ala Ile His Val Asn Arg Thr Tyr Asp Glu Gln Val Thr Ser Arg 
    130                 135                 140                 


Ala Gln Glu Pro Leu Ser Ser Val Arg Arg Arg Ala Leu Leu Arg Lys 
145                 150                 155                 160 


Ala Ser Ser Leu Pro Pro Thr Thr Ala His Ile Leu Ser Ala Leu Leu 
                165                 170                 175     


Glu Ser Arg Val Asn Leu Pro Arg Tyr Pro Pro Thr Ala Ile Asp Tyr 
            180                 185                 190         


Lys Cys His Leu Lys Lys His Asn Glu Arg Gln Phe Phe Leu Glu Leu 
        195                 200                 205             


Val Lys Asp Ile Ser Asn Asp Leu Asp Leu Thr Ser Leu Ser Tyr Lys 
    210                 215                 220                 


Ile Leu Ile Phe Val Cys Leu Met Val Asp Ala Asp Arg Cys Ser Leu 
225                 230                 235                 240 


Phe Leu Val Glu Gly Ala Ala Ala Gly Lys Lys Thr Leu Val Ser Lys 
                245                 250                 255     


Phe Phe Asp Val His Ala Gly Thr Pro Leu Leu Pro Cys Ser Ser Thr 
            260                 265                 270         


Glu Asn Ser Asn Glu Val Gln Val Pro Trp Gly Lys Gly Ile Ile Gly 
        275                 280                 285             


Tyr Val Gly Glu His Gly Glu Thr Val Asn Ile Pro Asp Ala Tyr Gln 
    290                 295                 300                 


Asp Arg Arg Phe Asn Asp Glu Ile Asp Lys Leu Thr Gly Tyr Lys Thr 
305                 310                 315                 320 


Lys Ser Leu Leu Cys Met Pro Ile Arg Ser Ser Asp Gly Glu Ile Ile 
                325                 330                 335     


Gly Val Ala Gln Ala Ile Asn Lys Ile Pro Glu Gly Ala Pro Phe Thr 
            340                 345                 350         


Glu Asp Asp Glu Lys Val Met Gln Met Tyr Leu Pro Phe Cys Gly Ile 
        355                 360                 365             


Ala Ile Ser Asn Ala Gln Leu Phe Ala Ala Ser Arg Lys Glu Tyr Glu 
    370                 375                 380                 


Arg Ser Arg Ala Leu Leu Glu Val Val Asn Asp Leu Phe Glu Glu Gln 
385                 390                 395                 400 


Thr Asp Leu Glu Lys Ile Val Lys Lys Ile Met His Arg Ala Gln Thr 
                405                 410                 415     


Leu Leu Lys Cys Glu Arg Cys Ser Val Leu Leu Leu Glu Asp Ile Glu 
            420                 425                 430         


Ser Pro Val Val Lys Phe Thr Lys Ser Phe Glu Leu Met Ser Pro Lys 
        435                 440                 445             


Cys Ser Ala Asp Ala Glu Asn Ser Phe Lys Glu Ser Met Glu Lys Ser 
    450                 455                 460                 


Ser Tyr Ser Asp Trp Leu Ile Asn Asn Ser Ile Ala Glu Leu Val Ala 
465                 470                 475                 480 


Ser Thr Gly Leu Pro Val Asn Ile Ser Asp Ala Tyr Gln Asp Pro Arg 
                485                 490                 495     


Phe Asp Ala Glu Ala Asp Gln Ile Ser Gly Phe His Ile Arg Ser Val 
            500                 505                 510         


Leu Cys Val Pro Ile Trp Asn Ser Asn His Gln Ile Ile Gly Val Ala 
        515                 520                 525             


Gln Val Leu Asn Arg Leu Asp Gly Lys Pro Phe Asp Asp Ala Asp Gln 
    530                 535                 540                 


Arg Leu Phe Glu Ala Phe Val Ile Phe Cys Gly Leu Gly Ile Asn Asn 
545                 550                 555                 560 


Thr Ile Met Tyr Asp Gln Val Lys Lys Ser Trp Ala Lys Gln Ser Val 
                565                 570                 575     


Ala Leu Asp Val Leu Ser Tyr His Ala Thr Cys Ser Lys Ala Glu Val 
            580                 585                 590         


Asp Lys Phe Lys Ala Ala Asn Ile Pro Leu Val Ser Glu Leu Ala Ile 
        595                 600                 605             


Asp Asp Ile His Phe Asp Asp Phe Ser Leu Asp Val Asp Ala Met Ile 
    610                 615                 620                 


Thr Ala Ala Leu Arg Met Phe Met Glu Leu Gly Met Val Gln Lys Phe 
625                 630                 635                 640 


Lys Ile Asp Tyr Glu Thr Leu Cys Arg Trp Leu Leu Thr Val Arg Lys 
                645                 650                 655     


Asn Tyr Arg Met Val Leu Tyr His Asn Trp Arg His Ala Phe Asn Val 
            660                 665                 670         


Cys Gln Leu Met Phe Ala Met Leu Thr Thr Ala Gly Phe Gln Asp Ile 
        675                 680                 685             


Leu Thr Glu Val Glu Ile Leu Ala Val Ile Val Gly Cys Leu Cys His 
    690                 695                 700                 


Asp Leu Asp His Arg Gly Thr Asn Asn Ala Phe Gln Ala Lys Ser Gly 
705                 710                 715                 720 


Ser Ala Leu Ala Gln Leu Tyr Gly Thr Ser Ala Thr Leu Glu His His 
                725                 730                 735     


His Phe Asn His Ala Val Met Ile Leu Gln Ser Glu Gly His Asn Ile 
            740                 745                 750         


Phe Ala Asn Leu Ser Ser Lys Glu Tyr Ser Asp Leu Met Gln Leu Leu 
        755                 760                 765             


Lys Gln Ser Ile Leu Ala Thr Asp Leu Thr Leu Tyr Phe Glu Arg Arg 
    770                 775                 780                 


Thr Glu Phe Phe Glu Leu Val Ser Lys Gly Glu Tyr Asp Trp Asn Ile 
785                 790                 795                 800 


Lys Asn His Arg Asp Ile Phe Arg Ser Met Leu Met Thr Ala Cys Asp 
                805                 810                 815     


Leu Gly Ala Val Thr Lys Pro Trp Glu Ile Ser Arg Gln Val Ala Glu 
            820                 825                 830         


Leu Val Thr Ser Glu Phe Phe Glu Gln Gly Asp Arg Glu Arg Leu Glu 
        835                 840                 845             


Leu Lys Leu Thr Pro Ser Ala Ile Phe Asp Arg Asn Arg Lys Asp Glu 
    850                 855                 860                 


Leu Pro Arg Leu Gln Leu Glu Trp Ile Asp Ser Ile Cys Met Pro Leu 
865                 870                 875                 880 


Tyr Gln Ala Leu Val Lys Val Asn Val Lys Leu Lys Pro Met Leu Asp 
                885                 890                 895     


Ser Val Ala Thr Asn Arg Ser Lys Trp Glu Glu Leu His Gln Lys Arg 
            900                 905                 910         


Leu Leu Ala Ser Thr Ala Ser Ser Ser Pro Ala Ser Val Met Val Ala 
        915                 920                 925             


Lys Glu Asp Arg Asn 
    930             


<210>  10142
<211>  575
<212>  PRT
<213>  Homo Sapiens

<400>  10142

Met Gln Met Tyr Leu Pro Phe Cys Gly Ile Ala Ile Ser Asn Ala Gln 
1               5                   10                  15      


Leu Phe Ala Ala Ser Arg Lys Glu Tyr Glu Arg Ser Arg Ala Leu Leu 
            20                  25                  30          


Glu Val Val Asn Asp Leu Phe Glu Glu Gln Thr Asp Leu Glu Lys Ile 
        35                  40                  45              


Val Lys Lys Ile Met His Arg Ala Gln Thr Leu Leu Lys Cys Glu Arg 
    50                  55                  60                  


Cys Ser Val Leu Leu Leu Glu Asp Ile Glu Ser Pro Val Val Lys Phe 
65                  70                  75                  80  


Thr Lys Ser Phe Glu Leu Met Ser Pro Lys Cys Ser Ala Asp Ala Glu 
                85                  90                  95      


Asn Ser Phe Lys Glu Ser Met Glu Lys Ser Ser Tyr Ser Asp Trp Leu 
            100                 105                 110         


Ile Asn Asn Ser Ile Ala Glu Leu Val Ala Ser Thr Gly Leu Pro Val 
        115                 120                 125             


Asn Ile Ser Asp Ala Tyr Gln Asp Pro Arg Phe Asp Ala Glu Ala Asp 
    130                 135                 140                 


Gln Ile Ser Gly Phe His Ile Arg Ser Val Leu Cys Val Pro Ile Trp 
145                 150                 155                 160 


Asn Ser Asn His Gln Ile Ile Gly Val Ala Gln Val Leu Asn Arg Leu 
                165                 170                 175     


Asp Gly Lys Pro Phe Asp Asp Ala Asp Gln Arg Leu Phe Glu Ala Phe 
            180                 185                 190         


Val Ile Phe Cys Gly Leu Gly Ile Asn Asn Thr Ile Met Tyr Asp Gln 
        195                 200                 205             


Val Lys Lys Ser Trp Ala Lys Gln Ser Val Ala Leu Asp Val Leu Ser 
    210                 215                 220                 


Tyr His Ala Thr Cys Ser Lys Ala Glu Val Asp Lys Phe Lys Ala Ala 
225                 230                 235                 240 


Asn Ile Pro Leu Val Ser Glu Leu Ala Ile Asp Asp Ile His Phe Asp 
                245                 250                 255     


Asp Phe Ser Leu Asp Val Asp Ala Met Ile Thr Ala Ala Leu Arg Met 
            260                 265                 270         


Phe Met Glu Leu Gly Met Val Gln Lys Phe Lys Ile Asp Tyr Glu Thr 
        275                 280                 285             


Leu Cys Arg Trp Leu Leu Thr Val Arg Lys Asn Tyr Arg Met Val Leu 
    290                 295                 300                 


Tyr His Asn Trp Arg His Ala Phe Asn Val Cys Gln Leu Met Phe Ala 
305                 310                 315                 320 


Met Leu Thr Thr Ala Gly Phe Gln Asp Ile Leu Thr Glu Val Glu Ile 
                325                 330                 335     


Leu Ala Val Ile Val Gly Cys Leu Cys His Asp Leu Asp His Arg Gly 
            340                 345                 350         


Thr Asn Asn Ala Phe Gln Ala Lys Ser Gly Ser Ala Leu Ala Gln Leu 
        355                 360                 365             


Tyr Gly Thr Ser Ala Thr Leu Glu His His His Phe Asn His Ala Val 
    370                 375                 380                 


Met Ile Leu Gln Ser Glu Gly His Asn Ile Phe Ala Asn Leu Ser Ser 
385                 390                 395                 400 


Lys Glu Tyr Ser Asp Leu Met Gln Leu Leu Lys Gln Ser Ile Leu Ala 
                405                 410                 415     


Thr Asp Leu Thr Leu Tyr Phe Glu Arg Arg Thr Glu Phe Phe Glu Leu 
            420                 425                 430         


Val Ser Lys Gly Glu Tyr Asp Trp Asn Ile Lys Asn His Arg Asp Ile 
        435                 440                 445             


Phe Arg Ser Met Leu Met Thr Ala Cys Asp Leu Gly Ala Val Thr Lys 
    450                 455                 460                 


Pro Trp Glu Ile Ser Arg Gln Val Ala Glu Leu Val Thr Ser Glu Phe 
465                 470                 475                 480 


Phe Glu Gln Gly Asp Arg Glu Arg Leu Glu Leu Lys Leu Thr Pro Ser 
                485                 490                 495     


Ala Ile Phe Asp Arg Asn Arg Lys Asp Glu Leu Pro Arg Leu Gln Leu 
            500                 505                 510         


Glu Trp Ile Asp Ser Ile Cys Met Pro Leu Tyr Gln Ala Leu Val Lys 
        515                 520                 525             


Val Asn Val Lys Leu Lys Pro Met Leu Asp Ser Val Ala Thr Asn Arg 
    530                 535                 540                 


Ser Lys Trp Glu Glu Leu His Gln Lys Arg Leu Leu Ala Ser Thr Ala 
545                 550                 555                 560 


Ser Ser Ser Pro Ala Ser Val Met Val Ala Lys Glu Asp Arg Asn 
                565                 570                 575 


<210>  10143
<211>  36
<212>  PRT
<213>  Homo Sapiens

<400>  10143

Met Gln Met Tyr Leu Pro Phe Cys Gly Ile Ala Ile Ser Asn Ala Gln 
1               5                   10                  15      


Leu Phe Ala Ala Ser Arg Lys Glu Tyr Glu Arg Ser Arg Ser Tyr Val 
            20                  25                  30          


Arg Asp Val Tyr 
        35      


<210>  10144
<211>  489
<212>  PRT
<213>  Homo Sapiens

<400>  10144

Met Ser Pro Lys Cys Ser Ala Asp Ala Glu Asn Ser Phe Lys Glu Ser 
1               5                   10                  15      


Met Glu Lys Ser Ser Tyr Ser Asp Trp Leu Ile Asn Asn Ser Ile Ala 
            20                  25                  30          


Glu Leu Val Ala Ser Thr Gly Leu Pro Val Asn Ile Ser Asp Ala Tyr 
        35                  40                  45              


Gln Asp Pro Arg Phe Asp Ala Glu Ala Asp Gln Ile Ser Gly Phe His 
    50                  55                  60                  


Ile Arg Ser Val Leu Cys Val Pro Ile Trp Asn Ser Asn His Gln Ile 
65                  70                  75                  80  


Ile Gly Val Ala Gln Val Leu Asn Arg Leu Asp Gly Lys Pro Phe Asp 
                85                  90                  95      


Asp Ala Asp Gln Arg Leu Phe Glu Ala Phe Val Ile Phe Cys Gly Leu 
            100                 105                 110         


Gly Ile Asn Asn Thr Ile Met Tyr Asp Gln Val Lys Lys Ser Trp Ala 
        115                 120                 125             


Lys Gln Ser Val Ala Leu Asp Val Leu Ser Tyr His Ala Thr Cys Ser 
    130                 135                 140                 


Lys Ala Glu Val Asp Lys Phe Lys Ala Ala Asn Ile Pro Leu Val Ser 
145                 150                 155                 160 


Glu Leu Ala Ile Asp Asp Ile His Phe Asp Asp Phe Ser Leu Asp Val 
                165                 170                 175     


Asp Ala Met Ile Thr Ala Ala Leu Arg Met Phe Met Glu Leu Gly Met 
            180                 185                 190         


Val Gln Lys Phe Lys Ile Asp Tyr Glu Thr Leu Cys Arg Trp Leu Leu 
        195                 200                 205             


Thr Val Arg Lys Asn Tyr Arg Met Val Leu Tyr His Asn Trp Arg His 
    210                 215                 220                 


Ala Phe Asn Val Cys Gln Leu Met Phe Ala Met Leu Thr Thr Ala Gly 
225                 230                 235                 240 


Phe Gln Asp Ile Leu Thr Glu Val Glu Ile Leu Ala Val Ile Val Gly 
                245                 250                 255     


Cys Leu Cys His Asp Leu Asp His Arg Gly Thr Asn Asn Ala Phe Gln 
            260                 265                 270         


Ala Lys Ser Gly Ser Ala Leu Ala Gln Leu Tyr Gly Thr Ser Ala Thr 
        275                 280                 285             


Leu Glu His His His Phe Asn His Ala Val Met Ile Leu Gln Ser Glu 
    290                 295                 300                 


Gly His Asn Ile Phe Ala Asn Leu Ser Ser Lys Glu Tyr Ser Asp Leu 
305                 310                 315                 320 


Met Gln Leu Leu Lys Gln Ser Ile Leu Ala Thr Asp Leu Thr Leu Tyr 
                325                 330                 335     


Phe Glu Arg Arg Thr Glu Phe Phe Glu Leu Val Ser Lys Gly Glu Tyr 
            340                 345                 350         


Asp Trp Asn Ile Lys Asn His Arg Asp Ile Phe Arg Ser Met Leu Met 
        355                 360                 365             


Thr Ala Cys Asp Leu Gly Ala Val Thr Lys Pro Trp Glu Ile Ser Arg 
    370                 375                 380                 


Gln Val Ala Glu Leu Val Thr Ser Glu Phe Phe Glu Gln Gly Asp Arg 
385                 390                 395                 400 


Glu Arg Leu Glu Leu Lys Leu Thr Pro Ser Ala Ile Phe Asp Arg Asn 
                405                 410                 415     


Arg Lys Asp Glu Leu Pro Arg Leu Gln Leu Glu Trp Ile Asp Ser Ile 
            420                 425                 430         


Cys Met Pro Leu Tyr Gln Ala Leu Val Lys Val Asn Val Lys Leu Lys 
        435                 440                 445             


Pro Met Leu Asp Ser Val Ala Thr Asn Arg Ser Lys Trp Glu Glu Leu 
    450                 455                 460                 


His Gln Lys Arg Leu Leu Ala Ser Thr Ala Ser Ser Ser Pro Ala Ser 
465                 470                 475                 480 


Val Met Val Ala Lys Glu Asp Arg Asn 
                485                 


<210>  10145
<211>  437
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  10145

Xaa Leu Pro Phe Cys Gly Ile Ala Ile Ser Asn Ala Gln Leu Phe Ala 
1               5                   10                  15      


Ala Ser Arg Lys Glu Tyr Glu Arg Ser Arg Ala Leu Leu Glu Val Val 
            20                  25                  30          


Asn Asp Leu Phe Glu Glu Gln Thr Asp Leu Glu Lys Ile Val Lys Lys 
        35                  40                  45              


Ile Met His Arg Ala Gln Thr Leu Leu Lys Cys Glu Arg Cys Ser Val 
    50                  55                  60                  


Leu Leu Leu Glu Asp Ile Glu Ser Pro Val Val Lys Phe Thr Lys Ser 
65                  70                  75                  80  


Phe Glu Leu Met Ser Pro Lys Cys Ser Ala Asp Ala Glu Asn Ser Phe 
                85                  90                  95      


Lys Glu Ser Met Glu Lys Ser Ser Tyr Ser Asp Trp Leu Ile Asn Asn 
            100                 105                 110         


Ser Ile Ala Glu Leu Val Ala Ser Thr Gly Leu Pro Val Asn Ile Ser 
        115                 120                 125             


Asp Ala Tyr Gln Asp Pro Arg Phe Asp Ala Glu Ala Asp Gln Ile Ser 
    130                 135                 140                 


Gly Phe His Ile Arg Ser Val Leu Cys Val Pro Ile Trp Asn Ser Asn 
145                 150                 155                 160 


His Gln Ile Ile Gly Val Ala Gln Val Leu Asn Arg Leu Asp Gly Lys 
                165                 170                 175     


Pro Phe Asp Asp Ala Asp Gln Arg Leu Phe Glu Val Leu Ser Tyr His 
            180                 185                 190         


Ala Thr Cys Ser Lys Ala Glu Val Asp Lys Phe Lys Ala Ala Asn Ile 
        195                 200                 205             


Pro Leu Val Ser Glu Leu Ala Ile Asp Asp Ile His Phe Asp Asp Phe 
    210                 215                 220                 


Ser Leu Asp Val Asp Ala Met Ile Thr Ala Ala Leu Arg Met Phe Met 
225                 230                 235                 240 


Glu Leu Gly Met Val Gln Lys Phe Lys Ile Asp Tyr Glu Thr Leu Cys 
                245                 250                 255     


Arg Trp Leu Leu Thr Val Arg Lys Asn Tyr Arg Met Val Leu Tyr His 
            260                 265                 270         


Asn Trp Arg His Ala Phe Asn Val Cys Gln Leu Met Phe Ala Met Leu 
        275                 280                 285             


Thr Thr Ala Gly Phe Gln Asp Ile Leu Thr Glu Val Glu Ile Leu Ala 
    290                 295                 300                 


Val Ile Val Gly Cys Leu Cys His Asp Leu Asp His Arg Gly Thr Asn 
305                 310                 315                 320 


Asn Ala Phe Gln Ala Lys Ser Gly Ser Ala Leu Ala Gln Leu Tyr Gly 
                325                 330                 335     


Thr Ser Ala Thr Leu Glu His His His Phe Asn His Ala Val Met Ile 
            340                 345                 350         


Leu Gln Ser Glu Gly His Asn Ile Phe Ala Asn Leu Ser Ser Lys Glu 
        355                 360                 365             


Tyr Ser Asp Leu Met Gln Leu Leu Lys Gln Ser Ile Leu Ala Thr Asp 
    370                 375                 380                 


Leu Thr Leu Tyr Phe Glu Arg Arg Thr Glu Phe Phe Glu Leu Val Ser 
385                 390                 395                 400 


Lys Gly Glu Tyr Asp Trp Asn Ile Lys Asn His Arg Asp Ile Phe Arg 
                405                 410                 415     


Ser Met Leu Met Thr Ala Cys Asp Leu Gly Ala Val Thr Lys Pro Trp 
            420                 425                 430         


Glu Ile Ser Arg Gln 
        435         


<210>  10146
<211>  136
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  10146

Xaa Val Leu Pro Leu Val Glu Glu Arg Lys Ile Ser Met Leu Met Thr 
1               5                   10                  15      


Ala Cys Asp Leu Gly Ala Val Thr Lys Pro Trp Glu Ile Ser Arg Gln 
            20                  25                  30          


Val Ala Glu Leu Val Thr Ser Glu Phe Phe Glu Gln Gly Asp Arg Glu 
        35                  40                  45              


Arg Leu Glu Leu Lys Leu Thr Pro Ser Ala Ile Phe Asp Arg Asn Arg 
    50                  55                  60                  


Lys Asp Glu Leu Pro Arg Leu Gln Leu Glu Trp Ile Asp Ser Ile Cys 
65                  70                  75                  80  


Met Pro Leu Tyr Gln Ala Leu Val Lys Val Asn Val Lys Leu Lys Pro 
                85                  90                  95      


Met Leu Asp Ser Val Ala Thr Asn Arg Ser Lys Trp Glu Glu Leu His 
            100                 105                 110         


Gln Lys Arg Leu Leu Ala Ser Thr Ala Ser Ser Ser Pro Ala Ser Val 
        115                 120                 125             


Met Val Ala Lys Glu Asp Arg Asn 
    130                 135     


<210>  10147
<211>  327
<212>  PRT
<213>  Homo Sapiens

<400>  10147

Phe Pro Thr Ala Ser Ser Val Pro Glu His Lys Gly Val Gly Phe His 
1               5                   10                  15      


Ala Trp Asp Val Arg Asn Leu Arg Lys Leu Arg Gly Gln Val Pro Ala 
            20                  25                  30          


Gly Ser Leu Pro Pro Thr Asp Pro Ser Leu His Arg Trp Phe Leu Ala 
        35                  40                  45              


Pro Leu Pro Ser Pro Glu Val Ile Gly Val Ala Glu Leu Val Asn Lys 
    50                  55                  60                  


Ile Asn Gly Pro Trp Phe Ser Lys Phe Asp Glu Asp Leu Ala Thr Ala 
65                  70                  75                  80  


Phe Ser Ile Tyr Cys Gly Ile Ser Ile Ala His Ser Leu Leu Tyr Lys 
                85                  90                  95      


Lys Val Asn Glu Ala Gln Tyr Arg Ser His Leu Ala Asn Glu Met Met 
            100                 105                 110         


Met Tyr His Met Lys Val Ser Asp Asp Glu Tyr Thr Lys Leu Leu His 
        115                 120                 125             


Asp Gly Ile Gln Pro Val Ala Ala Ile Asp Ser Asn Phe Ala Ser Phe 
    130                 135                 140                 


Thr Tyr Thr Pro Arg Ser Leu Pro Glu Asp Asp Thr Ser Met Ala Ile 
145                 150                 155                 160 


Leu Ser Met Leu Gln Asp Met Asn Phe Ile Asn Asn Tyr Lys Ile Asp 
                165                 170                 175     


Cys Pro Thr Leu Ala Arg Phe Cys Leu Met Val Lys Lys Gly Tyr Arg 
            180                 185                 190         


Asp Pro Pro Tyr His Asn Trp Met His Ala Phe Ser Val Ser His Phe 
        195                 200                 205             


Cys Tyr Leu Leu Tyr Lys Asn Leu Glu Leu Thr Asn Tyr Leu Glu Asp 
    210                 215                 220                 


Ile Glu Ile Phe Ala Leu Phe Ile Ser Cys Met Cys His Asp Leu Asp 
225                 230                 235                 240 


His Arg Gly Thr Asn Asn Ser Phe Gln Val Ala Ser Lys Ser Val Leu 
                245                 250                 255     


Ala Ala Leu Tyr Ser Ser Glu Gly Ser Val Met Glu Arg His His Phe 
            260                 265                 270         


Ala Gln Ala Ile Ala Ile Leu Asn Thr His Gly Cys Asn Ile Phe Asp 
        275                 280                 285             


His Phe Ser Arg Lys Asp Tyr Gln Arg Met Leu Asp Leu Met Arg Asp 
    290                 295                 300                 


Ile Ile Leu Ala Thr Asp Leu Ala His His Leu Arg Ile Phe Lys Asp 
305                 310                 315                 320 


Leu Gln Lys Met Ala Glu Gly 
                325         


<210>  10148
<211>  38
<212>  PRT
<213>  Homo Sapiens

<400>  10148

Met Gly Gln Ala Cys Gly His Ser Ile Leu Cys Arg Ser Gln Gln Tyr 
1               5                   10                  15      


Pro Ala Ala Arg Pro Ala Glu Pro Gln Pro Gly Pro Pro Cys Lys Gly 
            20                  25                  30          


Ala Arg Thr Pro Arg Glu 
        35              


<210>  10149
<211>  941
<212>  PRT
<213>  Homo Sapiens

<400>  10149

Met Gly Gln Ala Cys Gly His Ser Ile Leu Cys Arg Ser Gln Gln Tyr 
1               5                   10                  15      


Pro Ala Ala Arg Pro Ala Glu Pro Arg Gly Gln Gln Val Phe Leu Lys 
            20                  25                  30          


Pro Asp Glu Pro Pro Pro Pro Pro Gln Pro Cys Ala Asp Ser Leu Gln 
        35                  40                  45              


Asp Ala Leu Leu Ser Leu Gly Ser Val Ile Asp Ile Ser Gly Leu Gln 
    50                  55                  60                  


Arg Ala Val Lys Glu Ala Leu Ser Ala Val Leu Pro Arg Val Glu Thr 
65                  70                  75                  80  


Val Tyr Thr Tyr Leu Leu Asp Gly Glu Ser Gln Leu Val Cys Glu Asp 
                85                  90                  95      


Pro Pro His Glu Leu Pro Gln Glu Gly Lys Val Arg Glu Ala Ile Ile 
            100                 105                 110         


Ser Gln Lys Arg Leu Gly Cys Asn Gly Leu Gly Phe Ser Asp Leu Pro 
        115                 120                 125             


Gly Lys Pro Leu Ala Arg Leu Val Ala Pro Leu Ala Pro Asp Thr Gln 
    130                 135                 140                 


Val Leu Val Met Pro Leu Ala Asp Lys Glu Ala Gly Ala Val Ala Ala 
145                 150                 155                 160 


Val Ile Leu Val His Cys Gly Gln Leu Ser Asp Asn Glu Glu Trp Ser 
                165                 170                 175     


Leu Gln Ala Val Glu Lys His Thr Leu Val Ala Leu Arg Arg Val Gln 
            180                 185                 190         


Val Leu Gln Gln Arg Gly Pro Arg Glu Ala Pro Arg Ala Val Gln Asn 
        195                 200                 205             


Pro Pro Glu Gly Thr Ala Glu Asp Gln Lys Gly Gly Ala Ala Tyr Thr 
    210                 215                 220                 


Asp Arg Asp Arg Lys Ile Leu Gln Leu Cys Gly Glu Leu Tyr Asp Leu 
225                 230                 235                 240 


Asp Ala Ser Ser Leu Gln Leu Lys Val Leu Gln Tyr Leu Gln Gln Glu 
                245                 250                 255     


Thr Arg Ala Ser Arg Cys Cys Leu Leu Leu Val Ser Glu Asp Asn Leu 
            260                 265                 270         


Gln Leu Ser Cys Lys Val Ile Gly Asp Lys Val Leu Gly Glu Glu Val 
        275                 280                 285             


Ser Phe Pro Leu Thr Gly Cys Leu Gly Gln Val Val Glu Asp Lys Lys 
    290                 295                 300                 


Ser Ile Gln Leu Lys Asp Leu Thr Ser Glu Asp Val Gln Gln Leu Gln 
305                 310                 315                 320 


Ser Met Leu Gly Cys Glu Leu Gln Ala Met Leu Cys Val Pro Val Ile 
                325                 330                 335     


Ser Arg Ala Thr Asp Gln Val Val Ala Leu Ala Cys Ala Phe Asn Lys 
            340                 345                 350         


Leu Glu Gly Asp Leu Phe Thr Asp Glu Asp Glu His Val Ile Gln His 
        355                 360                 365             


Cys Phe His Tyr Thr Ser Thr Val Leu Thr Ser Thr Leu Ala Phe Gln 
    370                 375                 380                 


Lys Glu Gln Lys Leu Lys Cys Glu Cys Gln Ala Leu Leu Gln Val Ala 
385                 390                 395                 400 


Lys Asn Leu Phe Thr His Leu Asp Asp Val Ser Val Leu Leu Gln Glu 
                405                 410                 415     


Ile Ile Thr Glu Ala Arg Asn Leu Ser Asn Ala Glu Ile Cys Ser Val 
            420                 425                 430         


Phe Leu Leu Asp Gln Asn Glu Leu Val Ala Lys Val Phe Asp Gly Gly 
        435                 440                 445             


Val Val Asp Asp Glu Ser Tyr Glu Ile Arg Ile Pro Ala Asp Gln Gly 
    450                 455                 460                 


Ile Ala Gly His Val Ala Thr Thr Gly Gln Ile Leu Asn Ile Pro Asp 
465                 470                 475                 480 


Ala Tyr Ala His Pro Leu Phe Tyr Arg Gly Val Asp Asp Ser Thr Gly 
                485                 490                 495     


Phe Arg Thr Arg Asn Ile Leu Cys Phe Pro Ile Lys Asn Glu Asn Gln 
            500                 505                 510         


Glu Val Ile Gly Val Ala Glu Leu Val Asn Lys Ile Asn Gly Pro Trp 
        515                 520                 525             


Phe Ser Lys Phe Asp Glu Asp Leu Ala Thr Ala Phe Ser Ile Tyr Cys 
    530                 535                 540                 


Gly Ile Ser Ile Ala His Ser Leu Leu Tyr Lys Lys Val Asn Glu Ala 
545                 550                 555                 560 


Gln Tyr Arg Ser His Leu Ala Asn Glu Met Met Met Tyr His Met Lys 
                565                 570                 575     


Val Ser Asp Asp Glu Tyr Thr Lys Leu Leu His Asp Gly Ile Gln Pro 
            580                 585                 590         


Val Ala Ala Ile Asp Ser Asn Phe Ala Ser Phe Thr Tyr Thr Pro Arg 
        595                 600                 605             


Ser Leu Pro Glu Asp Asp Thr Ser Met Ala Ile Leu Ser Met Leu Gln 
    610                 615                 620                 


Asp Met Asn Phe Ile Asn Asn Tyr Lys Ile Asp Cys Pro Thr Leu Ala 
625                 630                 635                 640 


Arg Phe Cys Leu Met Val Lys Lys Gly Tyr Arg Asp Pro Pro Tyr His 
                645                 650                 655     


Asn Trp Met His Ala Phe Ser Val Ser His Phe Cys Tyr Leu Leu Tyr 
            660                 665                 670         


Lys Asn Leu Glu Leu Thr Asn Tyr Leu Glu Asp Ile Glu Ile Phe Ala 
        675                 680                 685             


Leu Phe Ile Ser Cys Met Cys His Asp Leu Asp His Arg Gly Thr Asn 
    690                 695                 700                 


Asn Ser Phe Gln Val Ala Ser Lys Ser Val Leu Ala Ala Leu Tyr Ser 
705                 710                 715                 720 


Ser Glu Gly Ser Val Met Glu Arg His His Phe Ala Gln Ala Ile Ala 
                725                 730                 735     


Ile Leu Asn Thr His Gly Cys Asn Ile Phe Asp His Phe Ser Arg Lys 
            740                 745                 750         


Asp Tyr Gln Arg Met Leu Asp Leu Met Arg Asp Ile Ile Leu Ala Thr 
        755                 760                 765             


Asp Leu Ala His His Leu Arg Ile Phe Lys Asp Leu Gln Lys Met Ala 
    770                 775                 780                 


Glu Val Gly Tyr Asp Arg Asn Asn Lys Gln His His Arg Leu Leu Leu 
785                 790                 795                 800 


Cys Leu Leu Met Thr Ser Cys Asp Leu Ser Asp Gln Thr Lys Gly Trp 
                805                 810                 815     


Lys Thr Thr Arg Lys Ile Ala Glu Leu Ile Tyr Lys Glu Phe Phe Ser 
            820                 825                 830         


Gln Gly Asp Leu Glu Lys Ala Met Gly Asn Arg Pro Met Glu Met Met 
        835                 840                 845             


Asp Arg Glu Lys Ala Tyr Ile Pro Glu Leu Gln Ile Ser Phe Met Glu 
    850                 855                 860                 


His Ile Ala Met Pro Ile Tyr Lys Leu Leu Gln Asp Leu Phe Pro Lys 
865                 870                 875                 880 


Ala Ala Glu Leu Tyr Glu Arg Val Ala Ser Asn Arg Glu His Trp Thr 
                885                 890                 895     


Lys Val Ser His Lys Phe Thr Ile Arg Gly Leu Pro Ser Asn Asn Ser 
            900                 905                 910         


Leu Asp Phe Leu Asp Glu Glu Tyr Glu Val Pro Asp Leu Asp Gly Thr 
        915                 920                 925             


Arg Ala Pro Ile Asn Gly Cys Cys Ser Leu Asp Ala Glu 
    930                 935                 940     


<210>  10150
<211>  826
<212>  PRT
<213>  Homo Sapiens

<400>  10150

Met Gly Gln Ala Cys Gly His Ser Ile Leu Cys Arg Ser Gln Gln Tyr 
1               5                   10                  15      


Pro Ala Ala Arg Pro Ala Glu Pro Arg Gly Gln Gln Val Phe Leu Lys 
            20                  25                  30          


Pro Asp Glu Pro Pro Pro Pro Pro Gln Pro Cys Ala Asp Ser Leu Gln 
        35                  40                  45              


Val His Cys Gly Gln Leu Ser Asp Asn Glu Glu Trp Ser Leu Gln Ala 
    50                  55                  60                  


Val Glu Lys His Thr Leu Val Ala Leu Arg Arg Val Gln Val Leu Gln 
65                  70                  75                  80  


Gln Arg Gly Pro Arg Glu Ala Pro Arg Ala Val Gln Asn Pro Pro Glu 
                85                  90                  95      


Gly Thr Ala Glu Asp Gln Lys Gly Gly Ala Ala Tyr Thr Asp Arg Asp 
            100                 105                 110         


Arg Lys Ile Leu Gln Leu Cys Gly Glu Leu Tyr Asp Leu Asp Ala Ser 
        115                 120                 125             


Ser Leu Gln Leu Lys Val Leu Gln Tyr Leu Gln Gln Glu Thr Arg Ala 
    130                 135                 140                 


Ser Arg Cys Cys Leu Leu Leu Val Ser Glu Asp Asn Leu Gln Leu Ser 
145                 150                 155                 160 


Cys Lys Val Ile Gly Asp Lys Val Leu Gly Glu Glu Val Ser Phe Pro 
                165                 170                 175     


Leu Thr Gly Cys Leu Gly Gln Val Val Glu Asp Lys Lys Ser Ile Gln 
            180                 185                 190         


Leu Lys Asp Leu Thr Ser Glu Asp Val Gln Gln Leu Gln Ser Met Leu 
        195                 200                 205             


Gly Cys Glu Leu Gln Ala Met Leu Cys Val Pro Val Ile Ser Arg Ala 
    210                 215                 220                 


Thr Asp Gln Val Val Ala Leu Ala Cys Ala Phe Asn Lys Leu Glu Gly 
225                 230                 235                 240 


Asp Leu Phe Thr Asp Glu Asp Glu His Val Ile Gln His Cys Phe His 
                245                 250                 255     


Tyr Thr Ser Thr Val Leu Thr Ser Thr Leu Ala Phe Gln Lys Glu Gln 
            260                 265                 270         


Lys Leu Lys Cys Glu Cys Gln Ala Leu Leu Gln Val Ala Lys Asn Leu 
        275                 280                 285             


Phe Thr His Leu Asp Asp Val Ser Val Leu Leu Gln Glu Ile Ile Thr 
    290                 295                 300                 


Glu Ala Arg Asn Leu Ser Asn Ala Glu Ile Cys Ser Val Phe Leu Leu 
305                 310                 315                 320 


Asp Gln Asn Glu Leu Val Ala Lys Val Phe Asp Gly Gly Val Val Asp 
                325                 330                 335     


Asp Glu Ser Tyr Glu Ile Arg Ile Pro Ala Asp Gln Gly Ile Ala Gly 
            340                 345                 350         


His Val Ala Thr Thr Gly Gln Ile Leu Asn Ile Pro Asp Ala Tyr Ala 
        355                 360                 365             


His Pro Leu Phe Tyr Arg Gly Val Asp Asp Ser Thr Gly Phe Arg Thr 
    370                 375                 380                 


Arg Asn Ile Leu Cys Phe Pro Ile Lys Asn Glu Asn Gln Glu Val Ile 
385                 390                 395                 400 


Gly Val Ala Glu Leu Val Asn Lys Ile Asn Gly Pro Trp Phe Ser Lys 
                405                 410                 415     


Phe Asp Glu Asp Leu Ala Thr Ala Phe Ser Ile Tyr Cys Gly Ile Ser 
            420                 425                 430         


Ile Ala His Ser Leu Leu Tyr Lys Lys Val Asn Glu Ala Gln Tyr Arg 
        435                 440                 445             


Ser His Leu Ala Asn Glu Met Met Met Tyr His Met Lys Val Ser Asp 
    450                 455                 460                 


Asp Glu Tyr Thr Lys Leu Leu His Asp Gly Ile Gln Pro Val Ala Ala 
465                 470                 475                 480 


Ile Asp Ser Asn Phe Ala Ser Phe Thr Tyr Thr Pro Arg Ser Leu Pro 
                485                 490                 495     


Glu Asp Asp Thr Ser Met Ala Ile Leu Ser Met Leu Gln Asp Met Asn 
            500                 505                 510         


Phe Ile Asn Asn Tyr Lys Ile Asp Cys Pro Thr Leu Ala Arg Phe Cys 
        515                 520                 525             


Leu Met Val Lys Lys Gly Tyr Arg Asp Pro Pro Tyr His Asn Trp Met 
    530                 535                 540                 


His Ala Phe Ser Val Ser His Phe Cys Tyr Leu Leu Tyr Lys Asn Leu 
545                 550                 555                 560 


Glu Leu Thr Asn Tyr Leu Glu Asp Ile Glu Ile Phe Ala Leu Phe Ile 
                565                 570                 575     


Ser Cys Met Cys His Asp Leu Asp His Arg Gly Thr Asn Asn Ser Phe 
            580                 585                 590         


Gln Val Ala Ser Lys Ser Val Leu Ala Ala Leu Tyr Ser Ser Glu Gly 
        595                 600                 605             


Ser Val Met Glu Arg His His Phe Ala Gln Ala Ile Ala Ile Leu Asn 
    610                 615                 620                 


Thr His Gly Cys Asn Ile Phe Asp His Phe Ser Arg Lys Asp Tyr Gln 
625                 630                 635                 640 


Arg Met Leu Asp Leu Met Arg Asp Ile Ile Leu Ala Thr Asp Leu Ala 
                645                 650                 655     


His His Leu Arg Ile Phe Lys Asp Leu Gln Lys Met Ala Glu Val Gly 
            660                 665                 670         


Tyr Asp Arg Asn Asn Lys Gln His His Arg Leu Leu Leu Cys Leu Leu 
        675                 680                 685             


Met Thr Ser Cys Asp Leu Ser Asp Gln Thr Lys Gly Trp Lys Thr Thr 
    690                 695                 700                 


Arg Lys Ile Ala Glu Leu Ile Tyr Lys Glu Phe Phe Ser Gln Gly Asp 
705                 710                 715                 720 


Leu Glu Lys Ala Met Gly Asn Arg Pro Met Glu Met Met Asp Arg Glu 
                725                 730                 735     


Lys Ala Tyr Ile Pro Glu Leu Gln Ile Ser Phe Met Glu His Ile Ala 
            740                 745                 750         


Met Pro Ile Tyr Lys Leu Leu Gln Asp Leu Phe Pro Lys Ala Ala Glu 
        755                 760                 765             


Leu Tyr Glu Arg Val Ala Ser Asn Arg Glu His Trp Thr Lys Val Ser 
    770                 775                 780                 


His Lys Phe Thr Ile Arg Gly Leu Pro Ser Asn Asn Ser Leu Asp Phe 
785                 790                 795                 800 


Leu Asp Glu Glu Tyr Glu Val Pro Asp Leu Asp Gly Thr Arg Ala Pro 
                805                 810                 815     


Ile Asn Gly Cys Cys Ser Leu Asp Ala Glu 
            820                 825     


<210>  10151
<211>  39
<212>  PRT
<213>  Homo Sapiens

<400>  10151

Met Gly Gln Ala Cys Gly His Ser Ile Leu Cys Arg Ser Gln Gln Tyr 
1               5                   10                  15      


Pro Ala Ala Arg Pro Ala Glu Pro Ser Leu Gln Leu Pro Glu His Cys 
            20                  25                  30          


Phe His Thr Cys Asp Leu Ile 
        35                  


<210>  10152
<211>  932
<212>  PRT
<213>  Homo Sapiens

<400>  10152

Met Lys Lys Gln Arg Ile Gln Glu Gly Lys Ser Leu Ala His Arg Arg 
1               5                   10                  15      


Gly Gln Gln Val Phe Leu Lys Pro Asp Glu Pro Pro Pro Pro Pro Gln 
            20                  25                  30          


Pro Cys Ala Asp Ser Leu Gln Asp Ala Leu Leu Ser Leu Gly Ser Val 
        35                  40                  45              


Ile Asp Ile Ser Gly Leu Gln Arg Ala Val Lys Glu Ala Leu Ser Ala 
    50                  55                  60                  


Val Leu Pro Arg Val Glu Thr Val Tyr Thr Tyr Leu Leu Asp Gly Glu 
65                  70                  75                  80  


Ser Gln Leu Val Cys Glu Asp Pro Pro His Glu Leu Pro Gln Glu Gly 
                85                  90                  95      


Lys Val Arg Glu Ala Ile Ile Ser Gln Lys Arg Leu Gly Cys Asn Gly 
            100                 105                 110         


Leu Gly Phe Ser Asp Leu Pro Gly Lys Pro Leu Ala Arg Leu Val Ala 
        115                 120                 125             


Pro Leu Ala Pro Asp Thr Gln Val Leu Val Met Pro Leu Ala Asp Lys 
    130                 135                 140                 


Glu Ala Gly Ala Val Ala Ala Val Ile Leu Val His Cys Gly Gln Leu 
145                 150                 155                 160 


Ser Asp Asn Glu Glu Trp Ser Leu Gln Ala Val Glu Lys His Thr Leu 
                165                 170                 175     


Val Ala Leu Arg Arg Val Gln Val Leu Gln Gln Arg Gly Pro Arg Glu 
            180                 185                 190         


Ala Pro Arg Ala Val Gln Asn Pro Pro Glu Gly Thr Ala Glu Asp Gln 
        195                 200                 205             


Lys Gly Gly Ala Ala Tyr Thr Asp Arg Asp Arg Lys Ile Leu Gln Leu 
    210                 215                 220                 


Cys Gly Glu Leu Tyr Asp Leu Asp Ala Ser Ser Leu Gln Leu Lys Val 
225                 230                 235                 240 


Leu Gln Tyr Leu Gln Gln Glu Thr Arg Ala Ser Arg Cys Cys Leu Leu 
                245                 250                 255     


Leu Val Ser Glu Asp Asn Leu Gln Leu Ser Cys Lys Val Ile Gly Asp 
            260                 265                 270         


Lys Val Leu Gly Glu Glu Val Ser Phe Pro Leu Thr Gly Cys Leu Gly 
        275                 280                 285             


Gln Val Val Glu Asp Lys Lys Ser Ile Gln Leu Lys Asp Leu Thr Ser 
    290                 295                 300                 


Glu Asp Val Gln Gln Leu Gln Ser Met Leu Gly Cys Glu Leu Gln Ala 
305                 310                 315                 320 


Met Leu Cys Val Pro Val Ile Ser Arg Ala Thr Asp Gln Val Val Ala 
                325                 330                 335     


Leu Ala Cys Ala Phe Asn Lys Leu Glu Gly Asp Leu Phe Thr Asp Glu 
            340                 345                 350         


Asp Glu His Val Ile Gln His Cys Phe His Tyr Thr Ser Thr Val Leu 
        355                 360                 365             


Thr Ser Thr Leu Ala Phe Gln Lys Glu Gln Lys Leu Lys Cys Glu Cys 
    370                 375                 380                 


Gln Ala Leu Leu Gln Val Ala Lys Asn Leu Phe Thr His Leu Asp Asp 
385                 390                 395                 400 


Val Ser Val Leu Leu Gln Glu Ile Ile Thr Glu Ala Arg Asn Leu Ser 
                405                 410                 415     


Asn Ala Glu Ile Cys Ser Val Phe Leu Leu Asp Gln Asn Glu Leu Val 
            420                 425                 430         


Ala Lys Val Phe Asp Gly Gly Val Val Asp Asp Glu Ser Tyr Glu Ile 
        435                 440                 445             


Arg Ile Pro Ala Asp Gln Gly Ile Ala Gly His Val Ala Thr Thr Gly 
    450                 455                 460                 


Gln Ile Leu Asn Ile Pro Asp Ala Tyr Ala His Pro Leu Phe Tyr Arg 
465                 470                 475                 480 


Gly Val Asp Asp Ser Thr Gly Phe Arg Thr Arg Asn Ile Leu Cys Phe 
                485                 490                 495     


Pro Ile Lys Asn Glu Asn Gln Glu Val Ile Gly Val Ala Glu Leu Val 
            500                 505                 510         


Asn Lys Ile Asn Gly Pro Trp Phe Ser Lys Phe Asp Glu Asp Leu Ala 
        515                 520                 525             


Thr Ala Phe Ser Ile Tyr Cys Gly Ile Ser Ile Ala His Ser Leu Leu 
    530                 535                 540                 


Tyr Lys Lys Val Asn Glu Ala Gln Tyr Arg Ser His Leu Ala Asn Glu 
545                 550                 555                 560 


Met Met Met Tyr His Met Lys Val Ser Asp Asp Glu Tyr Thr Lys Leu 
                565                 570                 575     


Leu His Asp Gly Ile Gln Pro Val Ala Ala Ile Asp Ser Asn Phe Ala 
            580                 585                 590         


Ser Phe Thr Tyr Thr Pro Arg Ser Leu Pro Glu Asp Asp Thr Ser Met 
        595                 600                 605             


Ala Ile Leu Ser Met Leu Gln Asp Met Asn Phe Ile Asn Asn Tyr Lys 
    610                 615                 620                 


Ile Asp Cys Pro Thr Leu Ala Arg Phe Cys Leu Met Val Lys Lys Gly 
625                 630                 635                 640 


Tyr Arg Asp Pro Pro Tyr His Asn Trp Met His Ala Phe Ser Val Ser 
                645                 650                 655     


His Phe Cys Tyr Leu Leu Tyr Lys Asn Leu Glu Leu Thr Asn Tyr Leu 
            660                 665                 670         


Glu Asp Ile Glu Ile Phe Ala Leu Phe Ile Ser Cys Met Cys His Asp 
        675                 680                 685             


Leu Asp His Arg Gly Thr Asn Asn Ser Phe Gln Val Ala Ser Lys Ser 
    690                 695                 700                 


Val Leu Ala Ala Leu Tyr Ser Ser Glu Gly Ser Val Met Glu Arg His 
705                 710                 715                 720 


His Phe Ala Gln Ala Ile Ala Ile Leu Asn Thr His Gly Cys Asn Ile 
                725                 730                 735     


Phe Asp His Phe Ser Arg Lys Asp Tyr Gln Arg Met Leu Asp Leu Met 
            740                 745                 750         


Arg Asp Ile Ile Leu Ala Thr Asp Leu Ala His His Leu Arg Ile Phe 
        755                 760                 765             


Lys Asp Leu Gln Lys Met Ala Glu Val Gly Tyr Asp Arg Asn Asn Lys 
    770                 775                 780                 


Gln His His Arg Leu Leu Leu Cys Leu Leu Met Thr Ser Cys Asp Leu 
785                 790                 795                 800 


Ser Asp Gln Thr Lys Gly Trp Lys Thr Thr Arg Lys Ile Ala Glu Leu 
                805                 810                 815     


Ile Tyr Lys Glu Phe Phe Ser Gln Gly Asp Leu Glu Lys Ala Met Gly 
            820                 825                 830         


Asn Arg Pro Met Glu Met Met Asp Arg Glu Lys Ala Tyr Ile Pro Glu 
        835                 840                 845             


Leu Gln Ile Ser Phe Met Glu His Ile Ala Met Pro Ile Tyr Lys Leu 
    850                 855                 860                 


Leu Gln Asp Leu Phe Pro Lys Ala Ala Glu Leu Tyr Glu Arg Val Ala 
865                 870                 875                 880 


Ser Asn Arg Glu His Trp Thr Lys Val Ser His Lys Phe Thr Ile Arg 
                885                 890                 895     


Gly Leu Pro Ser Asn Asn Ser Leu Asp Phe Leu Asp Glu Glu Tyr Glu 
            900                 905                 910         


Val Pro Asp Leu Asp Gly Thr Arg Ala Pro Ile Asn Gly Cys Cys Ser 
        915                 920                 925             


Leu Asp Ala Glu 
    930         


<210>  10153
<211>  198
<212>  PRT
<213>  Homo Sapiens

<400>  10153

Met Leu Gln Asp Met Asn Phe Ile Asn Asn Tyr Lys Ile Asp Cys Pro 
1               5                   10                  15      


Thr Leu Ala Arg Phe Cys Leu Met Val Lys Lys Gly Tyr Arg Asp Pro 
            20                  25                  30          


Pro Tyr His Asn Trp Met His Ala Phe Ser Val Ser His Phe Cys Tyr 
        35                  40                  45              


Leu Leu Tyr Lys Asn Leu Glu Leu Thr Asn Tyr Leu Glu Asp Ile Glu 
    50                  55                  60                  


Ile Phe Ala Leu Phe Ile Ser Cys Met Cys His Asp Leu Asp His Arg 
65                  70                  75                  80  


Gly Thr Asn Asn Ser Phe Gln Val Ala Ser Lys Ser Val Leu Ala Ala 
                85                  90                  95      


Leu Tyr Ser Ser Glu Gly Ser Val Met Glu Arg His His Phe Ala Gln 
            100                 105                 110         


Ala Ile Ala Ile Leu Asn Thr His Gly Cys Asn Ile Phe Asp His Phe 
        115                 120                 125             


Ser Arg Lys Asp Tyr Gln Arg Met Leu Asp Leu Met Arg Asp Ile Ile 
    130                 135                 140                 


Leu Ala Thr Asp Leu Ala His His Leu Arg Ile Phe Lys Asp Leu Gln 
145                 150                 155                 160 


Lys Met Ala Glu Val Gly Tyr Asp Arg Asn Asn Lys Gln His His Arg 
                165                 170                 175     


Leu Leu Leu Cys Leu Leu Met Thr Ser Cys Asp Leu Ser Asp Gln Thr 
            180                 185                 190         


Lys Gly Trp Lys Thr Thr 
        195             


<210>  10154
<211>  178
<212>  PRT
<213>  Homo Sapiens

<400>  10154

Met Met Met Tyr His Met Lys Val Ser Asp Asp Glu Tyr Thr Lys Leu 
1               5                   10                  15      


Leu His Asp Gly Ile Gln Pro Val Ala Ala Ile Asp Ser Asn Phe Ala 
            20                  25                  30          


Ser Phe Thr Tyr Thr Pro Arg Ser Leu Pro Glu Asp Asp Thr Ser Met 
        35                  40                  45              


Ala Ile Leu Ser Met Leu Gln Asp Met Asn Phe Ile Asn Asn Tyr Lys 
    50                  55                  60                  


Ile Asp Cys Pro Thr Leu Ala Arg Phe Cys Leu Met Val Lys Lys Gly 
65                  70                  75                  80  


Tyr Arg Asp Pro Pro Tyr His Asn Trp Met His Ala Phe Ser Val Ser 
                85                  90                  95      


His Phe Cys Tyr Leu Leu Tyr Lys Asn Leu Glu Leu Thr Asn Tyr Leu 
            100                 105                 110         


Glu Asp Ile Glu Ile Phe Ala Leu Phe Ile Ser Cys Met Cys His Asp 
        115                 120                 125             


Leu Asp His Arg Gly Thr Asn Asn Ser Phe Gln Val Ala Ser Lys Ser 
    130                 135                 140                 


Val Leu Ala Ala Leu Tyr Ser Ser Glu Gly Ser Val Met Glu Arg His 
145                 150                 155                 160 


His Phe Ala Gln Ala Ile Ala Ile Leu Asn Thr His Gly Cys Asn Ile 
                165                 170                 175     


Phe Asp 
        


<210>  10155
<211>  87
<212>  PRT
<213>  Homo Sapiens

<400>  10155

Met Arg Arg Gln Pro Ala Ala Ser Leu Asp Pro Leu Ala Lys Glu Pro 
1               5                   10                  15      


Gly Pro Pro Gly Ser Arg Asp Asp Arg Leu Glu Asp Ala Leu Leu Ser 
            20                  25                  30          


Leu Gly Ser Val Ile Asp Ile Ser Gly Leu Gln Arg Ala Val Lys Glu 
        35                  40                  45              


Ala Leu Ser Ala Val Leu Pro Arg Val Glu Thr Val Tyr Thr Tyr Leu 
    50                  55                  60                  


Leu Asp Gly Glu Ser Gln Leu Val Cys Glu Asp Pro Pro His Glu Leu 
65                  70                  75                  80  


Pro Gln Glu Gly Lys Val Arg 
                85          


<210>  10156
<211>  144
<212>  PRT
<213>  Homo Sapiens

<400>  10156

Met Arg Arg Gln Pro Ala Ala Ser Leu Asp Pro Leu Ala Lys Glu Pro 
1               5                   10                  15      


Gly Pro Pro Gly Ser Arg Asp Asp Arg Leu Glu Asp Ala Leu Leu Ser 
            20                  25                  30          


Leu Gly Ser Val Ile Asp Ile Ser Gly Leu Gln Arg Ala Val Lys Glu 
        35                  40                  45              


Ala Leu Ser Ala Val Leu Pro Arg Val Glu Thr Val Tyr Thr Tyr Leu 
    50                  55                  60                  


Leu Asp Gly Glu Ser Gln Leu Val Cys Glu Asp Pro Pro His Glu Leu 
65                  70                  75                  80  


Pro Gln Glu Gly Lys Val Arg Glu Ala Ile Ile Ser Gln Lys Arg Leu 
                85                  90                  95      


Gly Cys Asn Gly Leu Gly Phe Ser Asp Leu Pro Gly Lys Pro Leu Ala 
            100                 105                 110         


Arg Leu Val Ala Pro Leu Ala Pro Asp Thr Gln Val Leu Val Met Pro 
        115                 120                 125             


Leu Ala Asp Lys Glu Ala Gly Ala Val Ala Ala Val Ile Leu Val His 
    130                 135                 140                 


<210>  10157
<211>  920
<212>  PRT
<213>  Homo Sapiens

<400>  10157

Met Arg Arg Gln Pro Ala Ala Ser Leu Asp Pro Leu Ala Lys Glu Pro 
1               5                   10                  15      


Gly Pro Pro Gly Ser Arg Asp Asp Arg Leu Glu Asp Ala Leu Leu Ser 
            20                  25                  30          


Leu Gly Ser Val Ile Asp Ile Ser Gly Leu Gln Arg Ala Val Lys Glu 
        35                  40                  45              


Ala Leu Ser Ala Val Leu Pro Arg Val Glu Thr Val Tyr Thr Tyr Leu 
    50                  55                  60                  


Leu Asp Gly Glu Ser Gln Leu Val Cys Glu Asp Pro Pro His Glu Leu 
65                  70                  75                  80  


Pro Gln Glu Gly Lys Val Arg Glu Ala Ile Ile Ser Gln Lys Arg Leu 
                85                  90                  95      


Gly Cys Asn Gly Leu Gly Phe Ser Asp Leu Pro Gly Lys Pro Leu Ala 
            100                 105                 110         


Arg Leu Val Ala Pro Leu Ala Pro Asp Thr Gln Val Leu Val Met Pro 
        115                 120                 125             


Leu Ala Asp Lys Glu Ala Gly Ala Val Ala Ala Val Ile Leu Val His 
    130                 135                 140                 


Cys Gly Gln Leu Ser Asp Asn Glu Glu Trp Ser Leu Gln Ala Val Glu 
145                 150                 155                 160 


Lys His Thr Leu Val Ala Leu Arg Arg Val Gln Val Leu Gln Gln Arg 
                165                 170                 175     


Gly Pro Arg Glu Ala Pro Arg Ala Val Gln Asn Pro Pro Glu Gly Thr 
            180                 185                 190         


Ala Glu Asp Gln Lys Gly Gly Ala Ala Tyr Thr Asp Arg Asp Arg Lys 
        195                 200                 205             


Ile Leu Gln Leu Cys Gly Glu Leu Tyr Asp Leu Asp Ala Ser Ser Leu 
    210                 215                 220                 


Gln Leu Lys Val Leu Gln Tyr Leu Gln Gln Glu Thr Arg Ala Ser Arg 
225                 230                 235                 240 


Cys Cys Leu Leu Leu Val Ser Glu Asp Asn Leu Gln Leu Ser Cys Lys 
                245                 250                 255     


Val Ile Gly Asp Lys Val Leu Gly Glu Glu Val Ser Phe Pro Leu Thr 
            260                 265                 270         


Gly Cys Leu Gly Gln Val Val Glu Asp Lys Lys Ser Ile Gln Leu Lys 
        275                 280                 285             


Asp Leu Thr Ser Glu Asp Val Gln Gln Leu Gln Ser Met Leu Gly Cys 
    290                 295                 300                 


Glu Leu Gln Ala Met Leu Cys Val Pro Val Ile Ser Arg Ala Thr Asp 
305                 310                 315                 320 


Gln Val Val Ala Leu Ala Cys Ala Phe Asn Lys Leu Glu Gly Asp Leu 
                325                 330                 335     


Phe Thr Asp Glu Asp Glu His Val Ile Gln His Cys Phe His Tyr Thr 
            340                 345                 350         


Ser Thr Val Leu Thr Ser Thr Leu Ala Phe Gln Lys Glu Gln Lys Leu 
        355                 360                 365             


Lys Cys Glu Cys Gln Ala Leu Leu Gln Val Ala Lys Asn Leu Phe Thr 
    370                 375                 380                 


His Leu Asp Asp Val Ser Val Leu Leu Gln Glu Ile Ile Thr Glu Ala 
385                 390                 395                 400 


Arg Asn Leu Ser Asn Ala Glu Ile Cys Ser Val Phe Leu Leu Asp Gln 
                405                 410                 415     


Asn Glu Leu Val Ala Lys Val Phe Asp Gly Gly Val Val Asp Asp Glu 
            420                 425                 430         


Ser Tyr Glu Ile Arg Ile Pro Ala Asp Gln Gly Ile Ala Gly His Val 
        435                 440                 445             


Ala Thr Thr Gly Gln Ile Leu Asn Ile Pro Asp Ala Tyr Ala His Pro 
    450                 455                 460                 


Leu Phe Tyr Arg Gly Val Asp Asp Ser Thr Gly Phe Arg Thr Arg Asn 
465                 470                 475                 480 


Ile Leu Cys Phe Pro Ile Lys Asn Glu Asn Gln Glu Val Ile Gly Val 
                485                 490                 495     


Ala Glu Leu Val Asn Lys Ile Asn Gly Pro Trp Phe Ser Lys Phe Asp 
            500                 505                 510         


Glu Asp Leu Ala Thr Ala Phe Ser Ile Tyr Cys Gly Ile Ser Ile Ala 
        515                 520                 525             


His Ser Leu Leu Tyr Lys Lys Val Asn Glu Ala Gln Tyr Arg Ser His 
    530                 535                 540                 


Leu Ala Asn Glu Met Met Met Tyr His Met Lys Val Ser Asp Asp Glu 
545                 550                 555                 560 


Tyr Thr Lys Leu Leu His Asp Gly Ile Gln Pro Val Ala Ala Ile Asp 
                565                 570                 575     


Ser Asn Phe Ala Ser Phe Thr Tyr Thr Pro Arg Ser Leu Pro Glu Asp 
            580                 585                 590         


Asp Thr Ser Met Ala Ile Leu Ser Met Leu Gln Asp Met Asn Phe Ile 
        595                 600                 605             


Asn Asn Tyr Lys Ile Asp Cys Pro Thr Leu Ala Arg Phe Cys Leu Met 
    610                 615                 620                 


Val Lys Lys Gly Tyr Arg Asp Pro Pro Tyr His Asn Trp Met His Ala 
625                 630                 635                 640 


Phe Ser Val Ser His Phe Cys Tyr Leu Leu Tyr Lys Asn Leu Glu Leu 
                645                 650                 655     


Thr Asn Tyr Leu Glu Asp Ile Glu Ile Phe Ala Leu Phe Ile Ser Cys 
            660                 665                 670         


Met Cys His Asp Leu Asp His Arg Gly Thr Asn Asn Ser Phe Gln Val 
        675                 680                 685             


Ala Ser Lys Ser Val Leu Ala Ala Leu Tyr Ser Ser Glu Gly Ser Val 
    690                 695                 700                 


Met Glu Arg His His Phe Ala Gln Ala Ile Ala Ile Leu Asn Thr His 
705                 710                 715                 720 


Gly Cys Asn Ile Phe Asp His Phe Ser Arg Lys Asp Tyr Gln Arg Met 
                725                 730                 735     


Leu Asp Leu Met Arg Asp Ile Ile Leu Ala Thr Asp Leu Ala His His 
            740                 745                 750         


Leu Arg Ile Phe Lys Asp Leu Gln Lys Met Ala Glu Val Gly Tyr Asp 
        755                 760                 765             


Arg Asn Asn Lys Gln His His Arg Leu Leu Leu Cys Leu Leu Met Thr 
    770                 775                 780                 


Ser Cys Asp Leu Ser Asp Gln Thr Lys Gly Trp Lys Thr Thr Arg Lys 
785                 790                 795                 800 


Ile Ala Glu Leu Ile Tyr Lys Glu Phe Phe Ser Gln Gly Asp Leu Glu 
                805                 810                 815     


Lys Ala Met Gly Asn Arg Pro Met Glu Met Met Asp Arg Glu Lys Ala 
            820                 825                 830         


Tyr Ile Pro Glu Leu Gln Ile Ser Phe Met Glu His Ile Ala Met Pro 
        835                 840                 845             


Ile Tyr Lys Leu Leu Gln Asp Leu Phe Pro Lys Ala Ala Glu Leu Tyr 
    850                 855                 860                 


Glu Arg Val Ala Ser Asn Arg Glu His Trp Thr Lys Val Ser His Lys 
865                 870                 875                 880 


Phe Thr Ile Arg Gly Leu Pro Ser Asn Asn Ser Leu Asp Phe Leu Asp 
                885                 890                 895     


Glu Glu Tyr Glu Val Pro Asp Leu Asp Gly Thr Arg Ala Pro Ile Asn 
            900                 905                 910         


Gly Cys Cys Ser Leu Asp Ala Glu 
        915                 920 


<210>  10158
<211>  92
<212>  PRT
<213>  Homo Sapiens

<400>  10158

Met Ser Tyr Ile Leu Lys Met Pro Gly Thr Cys Leu Pro Gly Glu Gly 
1               5                   10                  15      


Thr Thr Tyr Glu Leu Pro Pro Ser Ser Leu His Pro Ser Ser Ala Pro 
            20                  25                  30          


Val Thr Ser Gly Gly Thr Cys Pro Ala Leu Leu Thr Glu Ala Gly Trp 
        35                  40                  45              


Glu Ala Pro Ile Met Ala Phe Thr Glu Ala Ala Ser Ala Val Gly Pro 
    50                  55                  60                  


Ser Trp Thr His Ser Gly Ala Ser Arg Ser Ser Ser Ser Arg Thr Ser 
65                  70                  75                  80  


Arg Arg Arg Arg Arg Ser His Ala Pro Thr Ala Cys 
                85                  90          


<210>  10159
<211>  106
<212>  PRT
<213>  Homo Sapiens

<400>  10159

Met Val Leu Val Leu His His Ile Leu Ile Ala Val Val Gln Phe Leu 
1               5                   10                  15      


Arg Arg Gly Gln Gln Val Phe Leu Lys Pro Asp Glu Pro Pro Pro Pro 
            20                  25                  30          


Pro Gln Pro Cys Ala Asp Ser Leu Gln Asp Ala Leu Leu Ser Leu Gly 
        35                  40                  45              


Ser Val Ile Asp Ile Ser Gly Leu Gln Arg Ala Val Lys Glu Ala Leu 
    50                  55                  60                  


Ser Ala Val Leu Pro Arg Val Glu Thr Val Tyr Thr Tyr Leu Leu Asp 
65                  70                  75                  80  


Gly Glu Ser Gln Leu Val Cys Glu Asp Pro Pro His Glu Leu Pro Gln 
                85                  90                  95      


Glu Gly Lys Val Arg Cys Thr Val Ala Ser 
            100                 105     


<210>  10160
<211>  934
<212>  PRT
<213>  Homo Sapiens

<400>  10160

Met Val Leu Val Leu His His Ile Leu Ile Ala Val Val Gln Phe Leu 
1               5                   10                  15      


Arg Arg Gly Gln Gln Val Phe Leu Lys Pro Asp Glu Pro Pro Pro Pro 
            20                  25                  30          


Pro Gln Pro Cys Ala Asp Ser Leu Gln Asp Ala Leu Leu Ser Leu Gly 
        35                  40                  45              


Ser Val Ile Asp Ile Ser Gly Leu Gln Arg Ala Val Lys Glu Ala Leu 
    50                  55                  60                  


Ser Ala Val Leu Pro Arg Val Glu Thr Val Tyr Thr Tyr Leu Leu Asp 
65                  70                  75                  80  


Gly Glu Ser Gln Leu Val Cys Glu Asp Pro Pro His Glu Leu Pro Gln 
                85                  90                  95      


Glu Gly Lys Val Arg Glu Ala Ile Ile Ser Gln Lys Arg Leu Gly Cys 
            100                 105                 110         


Asn Gly Leu Gly Phe Ser Asp Leu Pro Gly Lys Pro Leu Ala Arg Leu 
        115                 120                 125             


Val Ala Pro Leu Ala Pro Asp Thr Gln Val Leu Val Met Pro Leu Ala 
    130                 135                 140                 


Asp Lys Glu Ala Gly Ala Val Ala Ala Val Ile Leu Val His Cys Gly 
145                 150                 155                 160 


Gln Leu Ser Asp Asn Glu Glu Trp Ser Leu Gln Ala Val Glu Lys His 
                165                 170                 175     


Thr Leu Val Ala Leu Arg Arg Val Gln Val Leu Gln Gln Arg Gly Pro 
            180                 185                 190         


Arg Glu Ala Pro Arg Ala Val Gln Asn Pro Pro Glu Gly Thr Ala Glu 
        195                 200                 205             


Asp Gln Lys Gly Gly Ala Ala Tyr Thr Asp Arg Asp Arg Lys Ile Leu 
    210                 215                 220                 


Gln Leu Cys Gly Glu Leu Tyr Asp Leu Asp Ala Ser Ser Leu Gln Leu 
225                 230                 235                 240 


Lys Val Leu Gln Tyr Leu Gln Gln Glu Thr Arg Ala Ser Arg Cys Cys 
                245                 250                 255     


Leu Leu Leu Val Ser Glu Asp Asn Leu Gln Leu Ser Cys Lys Val Ile 
            260                 265                 270         


Gly Asp Lys Val Leu Gly Glu Glu Val Ser Phe Pro Leu Thr Gly Cys 
        275                 280                 285             


Leu Gly Gln Val Val Glu Asp Lys Lys Ser Ile Gln Leu Lys Asp Leu 
    290                 295                 300                 


Thr Ser Glu Asp Val Gln Gln Leu Gln Ser Met Leu Gly Cys Glu Leu 
305                 310                 315                 320 


Gln Ala Met Leu Cys Val Pro Val Ile Ser Arg Ala Thr Asp Gln Val 
                325                 330                 335     


Val Ala Leu Ala Cys Ala Phe Asn Lys Leu Glu Gly Asp Leu Phe Thr 
            340                 345                 350         


Asp Glu Asp Glu His Val Ile Gln His Cys Phe His Tyr Thr Ser Thr 
        355                 360                 365             


Val Leu Thr Ser Thr Leu Ala Phe Gln Lys Glu Gln Lys Leu Lys Cys 
    370                 375                 380                 


Glu Cys Gln Ala Leu Leu Gln Val Ala Lys Asn Leu Phe Thr His Leu 
385                 390                 395                 400 


Asp Asp Val Ser Val Leu Leu Gln Glu Ile Ile Thr Glu Ala Arg Asn 
                405                 410                 415     


Leu Ser Asn Ala Glu Ile Cys Ser Val Phe Leu Leu Asp Gln Asn Glu 
            420                 425                 430         


Leu Val Ala Lys Val Phe Asp Gly Gly Val Val Asp Asp Glu Ser Tyr 
        435                 440                 445             


Glu Ile Arg Ile Pro Ala Asp Gln Gly Ile Ala Gly His Val Ala Thr 
    450                 455                 460                 


Thr Gly Gln Ile Leu Asn Ile Pro Asp Ala Tyr Ala His Pro Leu Phe 
465                 470                 475                 480 


Tyr Arg Gly Val Asp Asp Ser Thr Gly Phe Arg Thr Arg Asn Ile Leu 
                485                 490                 495     


Cys Phe Pro Ile Lys Asn Glu Asn Gln Glu Val Ile Gly Val Ala Glu 
            500                 505                 510         


Leu Val Asn Lys Ile Asn Gly Pro Trp Phe Ser Lys Phe Asp Glu Asp 
        515                 520                 525             


Leu Ala Thr Ala Phe Ser Ile Tyr Cys Gly Ile Ser Ile Ala His Ser 
    530                 535                 540                 


Leu Leu Tyr Lys Lys Val Asn Glu Ala Gln Tyr Arg Ser His Leu Ala 
545                 550                 555                 560 


Asn Glu Met Met Met Tyr His Met Lys Val Ser Asp Asp Glu Tyr Thr 
                565                 570                 575     


Lys Leu Leu His Asp Gly Ile Gln Pro Val Ala Ala Ile Asp Ser Asn 
            580                 585                 590         


Phe Ala Ser Phe Thr Tyr Thr Pro Arg Ser Leu Pro Glu Asp Asp Thr 
        595                 600                 605             


Ser Met Ala Ile Leu Ser Met Leu Gln Asp Met Asn Phe Ile Asn Asn 
    610                 615                 620                 


Tyr Lys Ile Asp Cys Pro Thr Leu Ala Arg Phe Cys Leu Met Val Lys 
625                 630                 635                 640 


Lys Gly Tyr Arg Asp Pro Pro Tyr His Asn Trp Met His Ala Phe Ser 
                645                 650                 655     


Val Ser His Phe Cys Tyr Leu Leu Tyr Lys Asn Leu Glu Leu Thr Asn 
            660                 665                 670         


Tyr Leu Glu Asp Ile Glu Ile Phe Ala Leu Phe Ile Ser Cys Met Cys 
        675                 680                 685             


His Asp Leu Asp His Arg Gly Thr Asn Asn Ser Phe Gln Val Ala Ser 
    690                 695                 700                 


Lys Ser Val Leu Ala Ala Leu Tyr Ser Ser Glu Gly Ser Val Met Glu 
705                 710                 715                 720 


Arg His His Phe Ala Gln Ala Ile Ala Ile Leu Asn Thr His Gly Cys 
                725                 730                 735     


Asn Ile Phe Asp His Phe Ser Arg Lys Asp Tyr Gln Arg Met Leu Asp 
            740                 745                 750         


Leu Met Arg Asp Ile Ile Leu Ala Thr Asp Leu Ala His His Leu Arg 
        755                 760                 765             


Ile Phe Lys Asp Leu Gln Lys Met Ala Glu Val Gly Tyr Asp Arg Asn 
    770                 775                 780                 


Asn Lys Gln His His Arg Leu Leu Leu Cys Leu Leu Met Thr Ser Cys 
785                 790                 795                 800 


Asp Leu Ser Asp Gln Thr Lys Gly Trp Lys Thr Thr Arg Lys Ile Ala 
                805                 810                 815     


Glu Leu Ile Tyr Lys Glu Phe Phe Ser Gln Gly Asp Leu Glu Lys Ala 
            820                 825                 830         


Met Gly Asn Arg Pro Met Glu Met Met Asp Arg Glu Lys Ala Tyr Ile 
        835                 840                 845             


Pro Glu Leu Gln Ile Ser Phe Met Glu His Ile Ala Met Pro Ile Tyr 
    850                 855                 860                 


Lys Leu Leu Gln Asp Leu Phe Pro Lys Ala Ala Glu Leu Tyr Glu Arg 
865                 870                 875                 880 


Val Ala Ser Asn Arg Glu His Trp Thr Lys Val Ser His Lys Phe Thr 
                885                 890                 895     


Ile Arg Gly Leu Pro Ser Asn Asn Ser Leu Asp Phe Leu Asp Glu Glu 
            900                 905                 910         


Tyr Glu Val Pro Asp Leu Asp Gly Thr Arg Ala Pro Ile Asn Gly Cys 
        915                 920                 925             


Cys Ser Leu Asp Ala Glu 
    930                 


<210>  10161
<211>  685
<212>  PRT
<213>  Homo Sapiens

<400>  10161

Met Val Leu Val Leu His His Ile Leu Ile Ala Val Val Gln Phe Leu 
1               5                   10                  15      


Arg Arg Gly Gln Gln Val Phe Leu Lys Pro Asp Glu Pro Pro Pro Pro 
            20                  25                  30          


Pro Gln Pro Cys Ala Asp Ser Leu Gln Asp Ala Leu Leu Ser Leu Gly 
        35                  40                  45              


Ser Val Ile Asp Ile Ser Gly Leu Gln Arg Ala Val Lys Glu Ala Leu 
    50                  55                  60                  


Ser Ala Val Leu Pro Arg Val Glu Thr Val Tyr Thr Tyr Leu Leu Asp 
65                  70                  75                  80  


Gly Glu Ser Gln Leu Val Cys Glu Asp Pro Pro His Glu Leu Pro Gln 
                85                  90                  95      


Glu Gly Lys Val Arg Phe Thr Asp Glu Asp Glu His Val Ile Gln His 
            100                 105                 110         


Cys Phe His Tyr Thr Ser Thr Val Leu Thr Ser Thr Leu Ala Phe Gln 
        115                 120                 125             


Lys Glu Gln Lys Leu Lys Cys Glu Cys Gln Ala Leu Leu Gln Val Ala 
    130                 135                 140                 


Lys Asn Leu Phe Thr His Leu Asp Asp Val Ser Val Leu Leu Gln Glu 
145                 150                 155                 160 


Ile Ile Thr Glu Ala Arg Asn Leu Ser Asn Ala Glu Ile Cys Ser Val 
                165                 170                 175     


Phe Leu Leu Asp Gln Asn Glu Leu Val Ala Lys Val Phe Asp Gly Gly 
            180                 185                 190         


Val Val Asp Asp Glu Ser Tyr Glu Ile Arg Ile Pro Ala Asp Gln Gly 
        195                 200                 205             


Ile Ala Gly His Val Ala Thr Thr Gly Gln Ile Leu Asn Ile Pro Asp 
    210                 215                 220                 


Ala Tyr Ala His Pro Leu Phe Tyr Arg Gly Val Asp Asp Ser Thr Gly 
225                 230                 235                 240 


Phe Arg Thr Arg Asn Ile Leu Cys Phe Pro Ile Lys Asn Glu Asn Gln 
                245                 250                 255     


Glu Val Ile Gly Val Ala Glu Leu Val Asn Lys Ile Asn Gly Pro Trp 
            260                 265                 270         


Phe Ser Lys Phe Asp Glu Asp Leu Ala Thr Ala Phe Ser Ile Tyr Cys 
        275                 280                 285             


Gly Ile Ser Ile Ala His Ser Leu Leu Tyr Lys Lys Val Asn Glu Ala 
    290                 295                 300                 


Gln Tyr Arg Ser His Leu Ala Asn Glu Met Met Met Tyr His Met Lys 
305                 310                 315                 320 


Val Ser Asp Asp Glu Tyr Thr Lys Leu Leu His Asp Gly Ile Gln Pro 
                325                 330                 335     


Val Ala Ala Ile Asp Ser Asn Phe Ala Ser Phe Thr Tyr Thr Pro Arg 
            340                 345                 350         


Ser Leu Pro Glu Asp Asp Thr Ser Met Ala Ile Leu Ser Met Leu Gln 
        355                 360                 365             


Asp Met Asn Phe Ile Asn Asn Tyr Lys Ile Asp Cys Pro Thr Leu Ala 
    370                 375                 380                 


Arg Phe Cys Leu Met Val Lys Lys Gly Tyr Arg Asp Pro Pro Tyr His 
385                 390                 395                 400 


Asn Trp Met His Ala Phe Ser Val Ser His Phe Cys Tyr Leu Leu Tyr 
                405                 410                 415     


Lys Asn Leu Glu Leu Thr Asn Tyr Leu Glu Asp Ile Glu Ile Phe Ala 
            420                 425                 430         


Leu Phe Ile Ser Cys Met Cys His Asp Leu Asp His Arg Gly Thr Asn 
        435                 440                 445             


Asn Ser Phe Gln Val Ala Ser Lys Ser Val Leu Ala Ala Leu Tyr Ser 
    450                 455                 460                 


Ser Glu Gly Ser Val Met Glu Arg His His Phe Ala Gln Ala Ile Ala 
465                 470                 475                 480 


Ile Leu Asn Thr His Gly Cys Asn Ile Phe Asp His Phe Ser Arg Lys 
                485                 490                 495     


Asp Tyr Gln Arg Met Leu Asp Leu Met Arg Asp Ile Ile Leu Ala Thr 
            500                 505                 510         


Asp Leu Ala His His Leu Arg Ile Phe Lys Asp Leu Gln Lys Met Ala 
        515                 520                 525             


Glu Val Gly Tyr Asp Arg Asn Asn Lys Gln His His Arg Leu Leu Leu 
    530                 535                 540                 


Cys Leu Leu Met Thr Ser Cys Asp Leu Ser Asp Gln Thr Lys Gly Trp 
545                 550                 555                 560 


Lys Thr Thr Arg Lys Ile Ala Glu Leu Ile Tyr Lys Glu Phe Phe Ser 
                565                 570                 575     


Gln Gly Asp Leu Glu Lys Ala Met Gly Asn Arg Pro Met Glu Met Met 
            580                 585                 590         


Asp Arg Glu Lys Ala Tyr Ile Pro Glu Leu Gln Ile Ser Phe Met Glu 
        595                 600                 605             


His Ile Ala Met Pro Ile Tyr Lys Leu Leu Gln Asp Leu Phe Pro Lys 
    610                 615                 620                 


Ala Ala Glu Leu Tyr Glu Arg Val Ala Ser Asn Arg Glu His Trp Thr 
625                 630                 635                 640 


Lys Val Ser His Lys Phe Thr Ile Arg Gly Leu Pro Ser Asn Asn Ser 
                645                 650                 655     


Leu Asp Phe Leu Asp Glu Glu Tyr Glu Val Pro Asp Leu Asp Gly Thr 
            660                 665                 670         


Arg Ala Pro Ile Asn Gly Cys Cys Ser Leu Asp Ala Glu 
        675                 680                 685 


<210>  10162
<211>  92
<212>  PRT
<213>  Homo Sapiens

<400>  10162

Met Val Leu Val Leu His His Ile Leu Ile Ala Val Val Gln Phe Leu 
1               5                   10                  15      


Arg Arg Gly Gln Gln Val Phe Leu Lys Pro Asp Glu Pro Pro Pro Pro 
            20                  25                  30          


Pro Gln Pro Cys Ala Asp Ser Leu Gln Glu Thr Val Tyr Thr Tyr Leu 
        35                  40                  45              


Leu Asp Gly Arg Leu Ser Ser Pro Arg Ser Gly Trp Ala Ala Met Gly 
    50                  55                  60                  


Trp Ala Ser Gln Thr Cys Gln Gly Ser Pro Trp Pro Gly Trp Trp Leu 
65                  70                  75                  80  


His Trp Leu Leu Ile Pro Lys Cys Trp Ser Cys Arg 
                85                  90          


<210>  10163
<211>  65
<212>  PRT
<213>  Homo Sapiens

<400>  10163

Met Val Leu Val Leu His His Ile Leu Ile Ala Val Val Gln Phe Leu 
1               5                   10                  15      


Arg Arg Gly Gln Gln Val Phe Leu Lys Pro Asp Glu Pro Pro Pro Pro 
            20                  25                  30          


Pro Gln Pro Cys Ala Asp Ser Leu Gln Pro Ala Trp Thr Pro Leu Gln 
        35                  40                  45              


Arg Ser Gln Asp Pro Gln Gly Val Glu Thr Thr Asp Trp Arg Thr Pro 
    50                  55                  60                  


Cys 
65  


<210>  10164
<211>  65
<212>  PRT
<213>  Homo Sapiens

<400>  10164

Met Val Leu Val Leu His His Ile Leu Ile Ala Val Val Gln Phe Leu 
1               5                   10                  15      


Arg Arg Gly Gln Gln Val Phe Leu Lys Pro Asp Glu Pro Pro Pro Pro 
            20                  25                  30          


Pro Gln Pro Cys Ala Asp Ser Leu Gln Pro Ala Trp Thr Pro Leu Gln 
        35                  40                  45              


Arg Ser Gln Asp Pro Gln Gly Val Glu Thr Thr Asp Trp Arg Thr Pro 
    50                  55                  60                  


Cys 
65  


<210>  10165
<211>  65
<212>  PRT
<213>  Homo Sapiens

<400>  10165

Met Val Leu Val Leu His His Ile Leu Ile Ala Val Val Gln Phe Leu 
1               5                   10                  15      


Arg Arg Gly Gln Gln Val Phe Leu Lys Pro Asp Glu Pro Pro Pro Pro 
            20                  25                  30          


Pro Gln Pro Cys Ala Asp Ser Leu Gln Pro Ala Trp Thr Pro Leu Gln 
        35                  40                  45              


Arg Ser Gln Asp Pro Gln Gly Val Glu Thr Thr Asp Trp Arg Thr Pro 
    50                  55                  60                  


Cys 
65  


<210>  10166
<211>  336
<212>  PRT
<213>  Homo Sapiens

<400>  10166

Pro Gly Leu Asp Arg Ser Arg Gly Arg Gly Arg Ala Glu Leu Gly Gly 
1               5                   10                  15      


Glu Val Gly Gly Leu Gly Asp Pro Gly Ser Arg Arg Arg Ala Arg Arg 
            20                  25                  30          


Gly Ala Glu Arg Arg Leu Arg Asp Pro Asp Thr Glu Val Arg Arg Gly 
        35                  40                  45              


Pro Leu Ser Asp Arg Arg Leu Ala Leu Ala Gly Glu Leu Tyr Asp Leu 
    50                  55                  60                  


Asp Ala Ser Ser Leu Gln Leu Lys Val Leu Gln Tyr Leu Gln Gln Glu 
65                  70                  75                  80  


Thr Arg Ala Ser Arg Cys Cys Leu Leu Leu Val Ser Glu Asp Asn Leu 
                85                  90                  95      


Gln Leu Ser Cys Lys Val Ile Gly Asp Lys Val Leu Gly Glu Glu Val 
            100                 105                 110         


Ser Phe Pro Leu Thr Gly Cys Leu Gly Gln Val Val Glu Asp Lys Lys 
        115                 120                 125             


Ser Ile Gln Leu Lys Asp Leu Thr Ser Glu Asp Val Gln Gln Leu Gln 
    130                 135                 140                 


Ser Met Leu Gly Cys Glu Leu Gln Ala Met Leu Cys Val Pro Val Ile 
145                 150                 155                 160 


Ser Arg Ala Thr Asp Gln Val Val Ala Leu Ala Cys Ala Phe Asn Lys 
                165                 170                 175     


Leu Glu Gly Asp Leu Phe Thr Asp Glu Asp Glu His Val Ile Gln His 
            180                 185                 190         


Cys Phe His Tyr Thr Ser Thr Val Leu Thr Ser Thr Leu Ala Phe Gln 
        195                 200                 205             


Lys Glu Gln Lys Leu Lys Cys Glu Cys Gln Ala Leu Leu Gln Val Ala 
    210                 215                 220                 


Lys Asn Leu Phe Thr His Leu Asp Asp Val Ser Val Leu Leu Gln Glu 
225                 230                 235                 240 


Ile Ile Thr Glu Ala Arg Asn Leu Ser Asn Ala Glu Ile Cys Ser Val 
                245                 250                 255     


Phe Leu Leu Asp Gln Asn Glu Leu Val Ala Lys Val Phe Asp Gly Gly 
            260                 265                 270         


Val Val Asp Asp Glu Ser Tyr Glu Ile Arg Ile Pro Ala Asp Gln Gly 
        275                 280                 285             


Ile Ala Gly His Val Ala Thr Thr Gly Gln Ile Leu Asn Ile Pro Asp 
    290                 295                 300                 


Ala Tyr Ala His Pro Leu Phe Tyr Arg Gly Val Asp Asp Ser Thr Gly 
305                 310                 315                 320 


Phe Arg Thr Arg Asn Ile Leu Cys Phe Pro Ile Lys Asn Glu Asn Gln 
                325                 330                 335     


<210>  10167
<211>  75
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  10167

Xaa Leu Trp Leu Val Ala Ser Gly Gly Arg His Ser Ala Phe Pro Val 
1               5                   10                  15      


Ser His Pro Lys Gly Val Gly Leu Ala Cys Leu Pro Ser Thr Val Ala 
            20                  25                  30          


Ser Thr Gly Gly Cys His Trp Glu Thr Gly Arg Ala Trp Glu Phe Arg 
        35                  40                  45              


Glu Leu Arg Pro Ala Trp Thr Pro Leu Gln Arg Ser Gln Asp Pro Gln 
    50                  55                  60                  


Gly Val Glu Thr Thr Asp Trp Arg Thr Pro Cys 
65                  70                  75  


<210>  10168
<211>  172
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  10168

Xaa Ser Ala Val Thr Pro Ser Pro Cys Leu Ser Leu Ser Gln Leu Gln 
1               5                   10                  15      


Gln Glu Thr Arg Ala Ser Arg Cys Cys Leu Leu Leu Val Ser Glu Asp 
            20                  25                  30          


Asn Leu Gln Leu Ser Cys Lys Val Ile Gly Asp Lys Val Leu Gly Glu 
        35                  40                  45              


Glu Val Ser Phe Pro Leu Thr Gly Cys Leu Gly Gln Val Val Glu Asp 
    50                  55                  60                  


Lys Lys Ser Ile Gln Leu Lys Asp Leu Thr Ser Glu Asp Val Gln Gln 
65                  70                  75                  80  


Leu Gln Ser Met Leu Gly Cys Glu Leu Gln Ala Met Leu Cys Val Pro 
                85                  90                  95      


Val Ile Ser Arg Ala Thr Asp Gln Val Val Ala Leu Ala Cys Ala Phe 
            100                 105                 110         


Asn Lys Leu Glu Gly Asp Leu Phe Thr Asp Glu Asp Glu His Val Ile 
        115                 120                 125             


Gln His Cys Phe His Tyr Thr Ser Thr Val Leu Thr Ser Thr Leu Ala 
    130                 135                 140                 


Phe Gln Lys Glu Gln Lys Leu Lys Cys Glu Cys Gln Ala Leu Leu Gln 
145                 150                 155                 160 


Val Ala Lys Asn Leu Phe Thr His Leu Asp Asp Val 
                165                 170         


<210>  10169
<211>  482
<212>  PRT
<213>  Homo Sapiens

<400>  10169

Met Glu Val Cys Tyr Gln Leu Pro Val Leu Pro Leu Asp Arg Pro Val 
1               5                   10                  15      


Pro Gln His Val Leu Ser Arg Arg Gly Ala Ile Ser Phe Ser Ser Ser 
            20                  25                  30          


Ser Ala Leu Phe Gly Cys Pro Asn Pro Arg Gln Leu Ser Gln Arg Arg 
        35                  40                  45              


Gly Ala Ile Ser Tyr Asp Ser Ser Asp Gln Thr Ala Leu Tyr Ile Arg 
    50                  55                  60                  


Met Leu Gly Asp Val Arg Val Arg Ser Arg Ala Gly Phe Glu Ser Glu 
65                  70                  75                  80  


Arg Arg Gly Ser His Pro Tyr Ile Asp Phe Arg Ile Phe His Ser Gln 
                85                  90                  95      


Ser Glu Ile Glu Val Ser Val Ser Ala Arg Asn Ile Arg Arg Leu Leu 
            100                 105                 110         


Ser Phe Gln Arg Tyr Leu Arg Ser Ser Arg Phe Phe Arg Gly Thr Ala 
        115                 120                 125             


Val Ser Asn Ser Leu Asn Ile Leu Asp Asp Asp Tyr Asn Gly Gln Ala 
    130                 135                 140                 


Lys Cys Met Leu Glu Lys Val Gly Asn Trp Asn Phe Asp Ile Phe Leu 
145                 150                 155                 160 


Phe Asp Arg Leu Thr Asn Gly Asn Ser Leu Val Ser Leu Thr Phe His 
                165                 170                 175     


Leu Phe Ser Leu His Gly Leu Ile Glu Tyr Phe His Leu Asp Met Met 
            180                 185                 190         


Lys Leu Arg Arg Phe Leu Val Met Ile Gln Glu Asp Tyr His Ser Gln 
        195                 200                 205             


Asn Pro Tyr His Asn Ala Val His Ala Ala Asp Val Thr Gln Ala Met 
    210                 215                 220                 


His Cys Tyr Leu Lys Glu Pro Lys Leu Ala Asn Ser Val Thr Pro Trp 
225                 230                 235                 240 


Asp Ile Leu Leu Ser Leu Ile Ala Ala Ala Thr His Asp Leu Asp His 
                245                 250                 255     


Pro Gly Val Asn Gln Pro Phe Leu Ile Lys Thr Asn His Tyr Leu Ala 
            260                 265                 270         


Thr Leu Tyr Lys Asn Thr Ser Val Leu Glu Asn His His Trp Arg Ser 
        275                 280                 285             


Ala Val Gly Leu Leu Arg Glu Ser Gly Leu Phe Ser His Leu Pro Leu 
    290                 295                 300                 


Glu Ser Arg Gln Gln Met Glu Thr Gln Ile Gly Ala Leu Ile Leu Ala 
305                 310                 315                 320 


Thr Asp Ile Ser Arg Gln Asn Glu Tyr Leu Ser Leu Phe Arg Ser His 
                325                 330                 335     


Leu Asp Arg Gly Asp Leu Cys Leu Glu Asp Thr Arg His Arg His Leu 
            340                 345                 350         


Val Leu Gln Met Ala Leu Lys Cys Ala Asp Ile Cys Asn Pro Cys Arg 
        355                 360                 365             


Thr Trp Glu Leu Ser Lys Gln Trp Ser Glu Lys Val Thr Glu Glu Phe 
    370                 375                 380                 


Phe His Gln Gly Asp Ile Glu Lys Lys Tyr His Leu Gly Val Ser Pro 
385                 390                 395                 400 


Leu Cys Asp Arg His Thr Glu Ser Ile Ala Asn Ile Gln Ile Gly Phe 
                405                 410                 415     


Met Thr Tyr Leu Val Glu Pro Leu Phe Thr Glu Trp Ala Arg Phe Ser 
            420                 425                 430         


Asn Thr Arg Leu Ser Gln Thr Met Leu Gly His Val Gly Leu Asn Lys 
        435                 440                 445             


Ala Ser Trp Lys Gly Leu Gln Arg Glu Gln Ser Ser Ser Glu Asp Thr 
    450                 455                 460                 


Asp Ala Ala Phe Glu Leu Asn Ser Gln Leu Leu Pro Gln Glu Asn Arg 
465                 470                 475                 480 


Leu Ser 
        


<210>  10170
<211>  424
<212>  PRT
<213>  Homo Sapiens

<400>  10170

Met Glu Val Cys Tyr Gln Leu Pro Val Leu Pro Leu Asp Arg Pro Val 
1               5                   10                  15      


Pro Gln His Val Leu Ser Arg Arg Gly Ala Ile Ser Phe Ser Ser Ser 
            20                  25                  30          


Ser Ala Leu Phe Gly Cys Pro Asn Pro Arg Gln Leu Ser Gln Arg Arg 
        35                  40                  45              


Gly Ala Ile Ser Tyr Asp Ser Ser Asp Gln Thr Ala Leu Tyr Ile Arg 
    50                  55                  60                  


Met Leu Gly Asp Val Arg Val Arg Ser Arg Ala Gly Phe Glu Ser Glu 
65                  70                  75                  80  


Arg Arg Gly Ser His Pro Tyr Ile Asp Phe Arg Ile Phe His Ser Gln 
                85                  90                  95      


Ser Glu Ile Glu Val Ser Val Ser Ala Arg Asn Ile Arg Arg Leu Leu 
            100                 105                 110         


Ser Phe Gln Arg Tyr Leu Arg Ser Ser Arg Phe Phe Arg Gly Thr Ala 
        115                 120                 125             


Val Ser Asn Ser Leu Asn Ile Leu Asp Asp Asp Tyr Asn Gly Gln Ala 
    130                 135                 140                 


Lys Cys Met Leu Glu Lys Val Gly Asn Trp Asn Phe Asp Ile Phe Leu 
145                 150                 155                 160 


Phe Asp Arg Leu Thr Asn Gly Asn Ser Leu Val Ser Leu Thr Phe His 
                165                 170                 175     


Leu Phe Ser Leu His Gly Leu Ile Glu Tyr Phe His Leu Asp Met Met 
            180                 185                 190         


Lys Leu Arg Arg Phe Leu Val Met Ile Gln Glu Asp Tyr His Ser Gln 
        195                 200                 205             


Asn Pro Tyr His Asn Ala Val His Ala Ala Asp Val Thr Gln Ala Met 
    210                 215                 220                 


His Cys Tyr Leu Lys Glu Pro Lys Leu Ala Asn Ser Val Thr Pro Trp 
225                 230                 235                 240 


Asp Ile Leu Leu Ser Leu Ile Ala Ala Ala Thr His Asp Leu Asp His 
                245                 250                 255     


Pro Gly Val Asn Gln Pro Phe Leu Ile Lys Thr Asn His Tyr Leu Ala 
            260                 265                 270         


Thr Leu Tyr Lys Asn Thr Ser Val Leu Glu Asn His His Trp Arg Ser 
        275                 280                 285             


Ala Val Gly Leu Leu Arg Glu Ser Gly Leu Phe Ser His Leu Pro Leu 
    290                 295                 300                 


Glu Ser Arg Gln Gln Met Glu Thr Gln Ile Gly Ala Leu Ile Leu Ala 
305                 310                 315                 320 


Thr Asp Ile Ser Arg Gln Asn Glu Tyr Leu Ser Leu Phe Arg Ser His 
                325                 330                 335     


Leu Asp Arg Gly Asp Leu Cys Leu Glu Asp Thr Arg His Arg His Leu 
            340                 345                 350         


Val Leu Gln Met Ala Leu Lys Cys Ala Asp Ile Cys Asn Pro Cys Arg 
        355                 360                 365             


Thr Trp Glu Leu Ser Lys Gln Trp Ser Glu Lys Val Thr Glu Glu Phe 
    370                 375                 380                 


Phe His Gln Gly Asp Ile Glu Lys Lys Tyr His Leu Gly Val Ser Pro 
385                 390                 395                 400 


Leu Cys Asp Arg His Thr Glu Ser Ile Ala Asn Ile Gln Ile Gly Asn 
                405                 410                 415     


Tyr Thr Tyr Leu Asp Ile Ala Gly 
            420                 


<210>  10171
<211>  86
<212>  PRT
<213>  Homo Sapiens

<400>  10171

Met Gly Ile Thr Leu Ile Trp Cys Leu Ala Leu Val Leu Ile Lys Trp 
1               5                   10                  15      


Ile Thr Ser Lys Arg Arg Gly Ala Ile Ser Tyr Asp Ser Ser Asp Gln 
            20                  25                  30          


Thr Ala Leu Tyr Ile Arg Met Leu Gly Asp Val Arg Val Arg Ser Arg 
        35                  40                  45              


Ala Gly Phe Glu Ser Glu Arg Arg Gly Ser His Pro Tyr Ile Asp Phe 
    50                  55                  60                  


Arg Ile Phe His Ser Gln Ser Glu Ile Glu Val Ser Val Ser Ala Arg 
65                  70                  75                  80  


Asn Ile Arg Arg Leu Leu 
                85      


<210>  10172
<211>  456
<212>  PRT
<213>  Homo Sapiens

<400>  10172

Met Gly Ile Thr Leu Ile Trp Cys Leu Ala Leu Val Leu Ile Lys Trp 
1               5                   10                  15      


Ile Thr Ser Lys Arg Arg Gly Ala Ile Ser Tyr Asp Ser Ser Asp Gln 
            20                  25                  30          


Thr Ala Leu Tyr Ile Arg Met Leu Gly Asp Val Arg Val Arg Ser Arg 
        35                  40                  45              


Ala Gly Phe Glu Ser Glu Arg Arg Gly Ser His Pro Tyr Ile Asp Phe 
    50                  55                  60                  


Arg Ile Phe His Ser Gln Ser Glu Ile Glu Val Ser Val Ser Ala Arg 
65                  70                  75                  80  


Asn Ile Arg Arg Leu Leu Ser Phe Gln Arg Tyr Leu Arg Ser Ser Arg 
                85                  90                  95      


Phe Phe Arg Gly Thr Ala Val Ser Asn Ser Leu Asn Ile Leu Asp Asp 
            100                 105                 110         


Asp Tyr Asn Gly Gln Ala Lys Cys Met Leu Glu Lys Val Gly Asn Trp 
        115                 120                 125             


Asn Phe Asp Ile Phe Leu Phe Asp Arg Leu Thr Asn Gly Asn Ser Leu 
    130                 135                 140                 


Val Ser Leu Thr Phe His Leu Phe Ser Leu His Gly Leu Ile Glu Tyr 
145                 150                 155                 160 


Phe His Leu Asp Met Met Lys Leu Arg Arg Phe Leu Val Met Ile Gln 
                165                 170                 175     


Glu Asp Tyr His Ser Gln Asn Pro Tyr His Asn Ala Val His Ala Ala 
            180                 185                 190         


Asp Val Thr Gln Ala Met His Cys Tyr Leu Lys Glu Pro Lys Leu Ala 
        195                 200                 205             


Asn Ser Val Thr Pro Trp Asp Ile Leu Leu Ser Leu Ile Ala Ala Ala 
    210                 215                 220                 


Thr His Asp Leu Asp His Pro Gly Val Asn Gln Pro Phe Leu Ile Lys 
225                 230                 235                 240 


Thr Asn His Tyr Leu Ala Thr Leu Tyr Lys Asn Thr Ser Val Leu Glu 
                245                 250                 255     


Asn His His Trp Arg Ser Ala Val Gly Leu Leu Arg Glu Ser Gly Leu 
            260                 265                 270         


Phe Ser His Leu Pro Leu Glu Ser Arg Gln Gln Met Glu Thr Gln Ile 
        275                 280                 285             


Gly Ala Leu Ile Leu Ala Thr Asp Ile Ser Arg Gln Asn Glu Tyr Leu 
    290                 295                 300                 


Ser Leu Phe Arg Ser His Leu Asp Arg Gly Asp Leu Cys Leu Glu Asp 
305                 310                 315                 320 


Thr Arg His Arg His Leu Val Leu Gln Met Ala Leu Lys Cys Ala Asp 
                325                 330                 335     


Ile Cys Asn Pro Cys Arg Thr Trp Glu Leu Ser Lys Gln Trp Ser Glu 
            340                 345                 350         


Lys Val Thr Glu Glu Phe Phe His Gln Gly Asp Ile Glu Lys Lys Tyr 
        355                 360                 365             


His Leu Gly Val Ser Pro Leu Cys Asp Arg His Thr Glu Ser Ile Ala 
    370                 375                 380                 


Asn Ile Gln Ile Gly Phe Met Thr Tyr Leu Val Glu Pro Leu Phe Thr 
385                 390                 395                 400 


Glu Trp Ala Arg Phe Ser Asn Thr Arg Leu Ser Gln Thr Met Leu Gly 
                405                 410                 415     


His Val Gly Leu Asn Lys Ala Ser Trp Lys Gly Leu Gln Arg Glu Gln 
            420                 425                 430         


Ser Ser Ser Glu Asp Thr Asp Ala Ala Phe Glu Leu Asn Ser Gln Leu 
        435                 440                 445             


Leu Pro Gln Glu Asn Arg Leu Ser 
    450                 455     


<210>  10173
<211>  243
<212>  PRT
<213>  Homo Sapiens

<400>  10173

Met Ala Arg Leu Trp Gly Ala Leu Ser Leu Trp Pro Leu Trp Ala Ala 
1               5                   10                  15      


Val Pro Trp Gly Gly Ala Ala Ala Val Gly Val Arg Ala Cys Ser Ser 
            20                  25                  30          


Thr Ala Ala Pro Asp Gly Val Glu Gly Pro Ala Leu Arg Arg Ser Tyr 
        35                  40                  45              


Trp Arg His Leu Arg Arg Leu Val Leu Gly Pro Pro Glu Pro Pro Phe 
    50                  55                  60                  


Ser His Val Cys Gln Val Gly Asp Pro Val Leu Arg Gly Val Ala Ala 
65                  70                  75                  80  


Pro Val Glu Arg Ala Gln Leu Gly Gly Pro Glu Leu Gln Arg Leu Thr 
                85                  90                  95      


Gln Arg Leu Val Gln Val Met Arg Arg Arg Arg Cys Val Gly Leu Ser 
            100                 105                 110         


Ala Pro Gln Leu Gly Val Pro Arg Gln Val Leu Ala Leu Glu Leu Pro 
        115                 120                 125             


Glu Ala Leu Cys Arg Glu Cys Pro Pro Arg Gln Arg Ala Leu Arg Gln 
    130                 135                 140                 


Met Glu Pro Phe Pro Leu Arg Val Phe Val Asn Pro Ser Leu Arg Val 
145                 150                 155                 160 


Leu Asp Ser Arg Leu Val Thr Phe Pro Glu Gly Cys Glu Ser Val Ala 
                165                 170                 175     


Gly Phe Leu Ala Cys Val Pro Arg Phe Gln Ala Val Gln Ile Ser Gly 
            180                 185                 190         


Leu Asp Pro Asn Gly Glu Gln Val Val Trp Gln Ala Ser Gly Trp Ala 
        195                 200                 205             


Ala Arg Ile Ile Gln His Glu Met Asp His Leu Gln Gly Cys Leu Phe 
    210                 215                 220                 


Ile Asp Lys Met Asp Ser Arg Thr Phe Thr Asn Val Tyr Trp Met Lys 
225                 230                 235                 240 


Val Asn Asp 
            


<210>  10174
<211>  86
<212>  PRT
<213>  Homo Sapiens

<400>  10174

Met Arg Thr Leu Ala Cys Leu Leu Leu Leu Gly Cys Gly Tyr Leu Ala 
1               5                   10                  15      


His Val Leu Ala Glu Glu Ala Glu Ile Pro Arg Glu Val Ile Glu Arg 
            20                  25                  30          


Leu Ala Arg Ser Gln Ile His Ser Ile Arg Asp Leu Gln Arg Leu Leu 
        35                  40                  45              


Glu Ile Asp Ser Val Gly Ser Glu Asp Ser Leu Asp Thr Ser Leu Arg 
    50                  55                  60                  


Ala His Gly Val His Ala Thr Lys His Val Pro Glu Lys Arg Pro Leu 
65                  70                  75                  80  


Pro Ile Arg Arg Lys Arg 
                85      


<210>  10175
<211>  196
<212>  PRT
<213>  Homo Sapiens

<400>  10175

Met Arg Thr Leu Ala Cys Leu Leu Leu Leu Gly Cys Gly Tyr Leu Ala 
1               5                   10                  15      


His Val Leu Ala Glu Glu Ala Glu Ile Pro Arg Glu Val Ile Glu Arg 
            20                  25                  30          


Leu Ala Arg Ser Gln Ile His Ser Ile Arg Asp Leu Gln Arg Leu Leu 
        35                  40                  45              


Glu Ile Asp Ser Val Gly Ser Glu Asp Ser Leu Asp Thr Ser Leu Arg 
    50                  55                  60                  


Ala His Gly Val His Ala Thr Lys His Val Pro Glu Lys Arg Pro Leu 
65                  70                  75                  80  


Pro Ile Arg Arg Lys Arg Ser Ile Glu Glu Ala Val Pro Ala Val Cys 
                85                  90                  95      


Lys Thr Arg Thr Val Ile Tyr Glu Ile Pro Arg Ser Gln Val Asp Pro 
            100                 105                 110         


Thr Ser Ala Asn Phe Leu Ile Trp Pro Pro Cys Val Glu Val Lys Arg 
        115                 120                 125             


Cys Thr Gly Cys Cys Asn Thr Ser Ser Val Lys Cys Gln Pro Ser Arg 
    130                 135                 140                 


Val His His Arg Ser Val Lys Val Ala Lys Val Glu Tyr Val Arg Lys 
145                 150                 155                 160 


Lys Pro Lys Leu Lys Glu Val Gln Val Arg Leu Glu Glu His Leu Glu 
                165                 170                 175     


Cys Ala Cys Ala Thr Thr Ser Leu Asn Pro Asp Tyr Arg Glu Glu Asp 
            180                 185                 190         


Thr Asp Val Arg 
        195     


<210>  10176
<211>  211
<212>  PRT
<213>  Homo Sapiens

<400>  10176

Met Arg Thr Leu Ala Cys Leu Leu Leu Leu Gly Cys Gly Tyr Leu Ala 
1               5                   10                  15      


His Val Leu Ala Glu Glu Ala Glu Ile Pro Arg Glu Val Ile Glu Arg 
            20                  25                  30          


Leu Ala Arg Ser Gln Ile His Ser Ile Arg Asp Leu Gln Arg Leu Leu 
        35                  40                  45              


Glu Ile Asp Ser Val Gly Ser Glu Asp Ser Leu Asp Thr Ser Leu Arg 
    50                  55                  60                  


Ala His Gly Val His Ala Thr Lys His Val Pro Glu Lys Arg Pro Leu 
65                  70                  75                  80  


Pro Ile Arg Arg Lys Arg Ser Ile Glu Glu Ala Val Pro Ala Val Cys 
                85                  90                  95      


Lys Thr Arg Thr Val Ile Tyr Glu Ile Pro Arg Ser Gln Val Asp Pro 
            100                 105                 110         


Thr Ser Ala Asn Phe Leu Ile Trp Pro Pro Cys Val Glu Val Lys Arg 
        115                 120                 125             


Cys Thr Gly Cys Cys Asn Thr Ser Ser Val Lys Cys Gln Pro Ser Arg 
    130                 135                 140                 


Val His His Arg Ser Val Lys Val Ala Lys Val Glu Tyr Val Arg Lys 
145                 150                 155                 160 


Lys Pro Lys Leu Lys Glu Val Gln Val Arg Leu Glu Glu His Leu Glu 
                165                 170                 175     


Cys Ala Cys Ala Thr Thr Ser Leu Asn Pro Asp Tyr Arg Glu Glu Asp 
            180                 185                 190         


Thr Gly Arg Pro Arg Glu Ser Gly Lys Lys Arg Lys Arg Lys Arg Leu 
        195                 200                 205             


Lys Pro Thr 
    210     


<210>  10177
<211>  205
<212>  PRT
<213>  Homo Sapiens

<400>  10177

Gln Arg Gln Ala Ala Ala Leu Gly Ser Gln Ser Pro Ser Pro Ala Gly 
1               5                   10                  15      


Leu Arg Ala Gly Ala Val Pro Pro Ala Arg Ala Cys Leu Gln Glu Ala 
            20                  25                  30          


Glu Ile Pro Arg Glu Val Ile Glu Arg Leu Ala Arg Ser Gln Ile His 
        35                  40                  45              


Ser Ile Arg Asp Leu Gln Arg Leu Leu Glu Ile Asp Ser Val Gly Ser 
    50                  55                  60                  


Glu Asp Ser Leu Asp Thr Ser Leu Arg Ala His Gly Val His Ala Thr 
65                  70                  75                  80  


Lys His Val Pro Glu Lys Arg Pro Leu Pro Ile Arg Arg Lys Arg Ser 
                85                  90                  95      


Ile Glu Glu Ala Val Pro Ala Val Cys Lys Thr Arg Thr Val Ile Tyr 
            100                 105                 110         


Glu Ile Pro Arg Ser Gln Val Asp Pro Thr Ser Ala Asn Phe Leu Ile 
        115                 120                 125             


Trp Pro Pro Cys Val Glu Val Lys Arg Cys Thr Gly Cys Cys Asn Thr 
    130                 135                 140                 


Ser Ser Val Lys Cys Gln Pro Ser Arg Val His His Arg Ser Val Lys 
145                 150                 155                 160 


Val Ala Lys Val Glu Tyr Val Arg Lys Lys Pro Lys Leu Lys Glu Val 
                165                 170                 175     


Gln Val Arg Leu Glu Glu His Leu Glu Cys Ala Cys Ala Thr Thr Ser 
            180                 185                 190         


Leu Asn Pro Asp Tyr Arg Glu Glu Asp Thr Asp Val Arg 
        195                 200                 205 


<210>  10178
<211>  226
<212>  PRT
<213>  Homo Sapiens

<400>  10178

Met Phe Ile Met Gly Leu Gly Asp Pro Ile Pro Glu Glu Leu Tyr Glu 
1               5                   10                  15      


Met Leu Ser Asp His Ser Ile Arg Ser Phe Asp Asp Leu Gln Arg Leu 
            20                  25                  30          


Leu His Gly Asp Pro Gly Glu Glu Asp Gly Ala Glu Leu Asp Leu Asn 
        35                  40                  45              


Met Thr Arg Ser His Ser Gly Gly Glu Leu Glu Ser Leu Ala Arg Gly 
    50                  55                  60                  


Arg Arg Ser Leu Gly Ser Leu Thr Ile Ala Glu Pro Ala Met Ile Ala 
65                  70                  75                  80  


Glu Cys Lys Thr Arg Thr Glu Val Phe Glu Ile Ser Arg Arg Leu Ile 
                85                  90                  95      


Asp Arg Thr Asn Ala Asn Phe Leu Val Trp Pro Pro Cys Val Glu Val 
            100                 105                 110         


Gln Arg Cys Ser Gly Cys Cys Asn Asn Arg Asn Val Gln Cys Arg Pro 
        115                 120                 125             


Thr Gln Val Gln Leu Arg Pro Val Gln Val Arg Lys Ile Glu Ile Val 
    130                 135                 140                 


Arg Lys Lys Pro Ile Phe Lys Lys Ala Thr Val Thr Leu Glu Asp His 
145                 150                 155                 160 


Leu Ala Cys Lys Cys Glu Thr Val Ala Ala Ala Arg Pro Val Thr Arg 
                165                 170                 175     


Ser Pro Gly Gly Ser Gln Glu Gln Arg Ala Lys Thr Pro Gln Thr Arg 
            180                 185                 190         


Val Thr Ile Arg Thr Val Arg Val Arg Arg Pro Pro Lys Gly Lys His 
        195                 200                 205             


Arg Lys Phe Lys His Thr His Asp Lys Thr Ala Leu Lys Glu Thr Leu 
    210                 215                 220                 


Gly Ala 
225     


<210>  10179
<211>  136
<212>  PRT
<213>  Homo Sapiens

<400>  10179

Met Leu Ser Asp His Ser Ile Arg Ser Phe Asp Asp Leu Gln Arg Leu 
1               5                   10                  15      


Leu His Gly Asp Pro Gly Glu Glu Asp Gly Ala Glu Leu Asp Leu Asn 
            20                  25                  30          


Met Thr Arg Ser His Ser Gly Gly Glu Leu Glu Ser Leu Ala Arg Gly 
        35                  40                  45              


Arg Arg Ser Leu Gly Ser Leu Thr Ile Ala Glu Pro Ala Met Ile Ala 
    50                  55                  60                  


Glu Cys Lys Thr Arg Thr Glu Val Phe Glu Ile Ser Arg Arg Leu Ile 
65                  70                  75                  80  


Asp Arg Thr Asn Ala Asn Phe Leu Val Trp Pro Pro Cys Val Glu Val 
                85                  90                  95      


Gln Arg Cys Ser Gly Cys Cys Asn Asn Arg Asn Val Gln Cys Arg Pro 
            100                 105                 110         


Thr Gln Val Gln Leu Arg Pro Val Gln Val Arg Lys Ile Glu Ile Val 
        115                 120                 125             


Arg Lys Lys Pro Ile Phe Lys Lys 
    130                 135     


<210>  10180
<211>  144
<212>  PRT
<213>  Homo Sapiens

<400>  10180

Met Leu Ser Asp His Ser Ile Arg Ser Phe Asp Asp Leu Gln Arg Leu 
1               5                   10                  15      


Leu His Gly Asp Pro Gly Glu Glu Asp Gly Ala Glu Leu Asp Leu Asn 
            20                  25                  30          


Met Thr Arg Ser His Ser Gly Gly Glu Leu Glu Ser Leu Ala Arg Gly 
        35                  40                  45              


Arg Arg Ser Leu Gly Ser Leu Thr Ile Ala Glu Pro Ala Met Ile Ala 
    50                  55                  60                  


Glu Cys Lys Thr Arg Thr Glu Val Phe Glu Ile Ser Arg Arg Leu Ile 
65                  70                  75                  80  


Asp Arg Thr Asn Ala Asn Phe Leu Val Trp Pro Pro Cys Val Glu Val 
                85                  90                  95      


Gln Arg Cys Ser Gly Cys Cys Asn Asn Arg Asn Val Gln Cys Arg Pro 
            100                 105                 110         


Thr Gln Val Gln Leu Arg Pro Val Gln Val Arg Lys Ile Glu Ile Val 
        115                 120                 125             


Arg Lys Lys Pro Ile Phe Lys Lys Ala Thr Val Thr Leu Glu Asp His 
    130                 135                 140                 


<210>  10181
<211>  241
<212>  PRT
<213>  Homo Sapiens

<400>  10181

Met Asn Arg Cys Trp Ala Leu Phe Leu Ser Leu Cys Cys Tyr Leu Arg 
1               5                   10                  15      


Leu Val Ser Ala Glu Gly Asp Pro Ile Pro Glu Glu Leu Tyr Glu Met 
            20                  25                  30          


Leu Ser Asp His Ser Ile Arg Ser Phe Asp Asp Leu Gln Arg Leu Leu 
        35                  40                  45              


His Gly Asp Pro Gly Glu Glu Asp Gly Ala Glu Leu Asp Leu Asn Met 
    50                  55                  60                  


Thr Arg Ser His Ser Gly Gly Glu Leu Glu Ser Leu Ala Arg Gly Arg 
65                  70                  75                  80  


Arg Ser Leu Gly Ser Leu Thr Ile Ala Glu Pro Ala Met Ile Ala Glu 
                85                  90                  95      


Cys Lys Thr Arg Thr Glu Val Phe Glu Ile Ser Arg Arg Leu Ile Asp 
            100                 105                 110         


Arg Thr Asn Ala Asn Phe Leu Val Trp Pro Pro Cys Val Glu Val Gln 
        115                 120                 125             


Arg Cys Ser Gly Cys Cys Asn Asn Arg Asn Val Gln Cys Arg Pro Thr 
    130                 135                 140                 


Gln Val Gln Leu Arg Pro Val Gln Val Arg Lys Ile Glu Ile Val Arg 
145                 150                 155                 160 


Lys Lys Pro Ile Phe Lys Lys Ala Thr Val Thr Leu Glu Asp His Leu 
                165                 170                 175     


Ala Cys Lys Cys Glu Thr Val Ala Ala Ala Arg Pro Val Thr Arg Ser 
            180                 185                 190         


Pro Gly Gly Ser Gln Glu Gln Arg Ala Lys Thr Pro Gln Thr Arg Val 
        195                 200                 205             


Thr Ile Arg Thr Val Arg Val Arg Arg Pro Pro Lys Gly Lys His Arg 
    210                 215                 220                 


Lys Phe Lys His Thr His Asp Lys Thr Ala Leu Lys Glu Thr Leu Gly 
225                 230                 235                 240 


Ala 
    


<210>  10182
<211>  50
<212>  PRT
<213>  Homo Sapiens

<400>  10182

Met Ser Leu Phe Gly Leu Leu Leu Leu Thr Ser Ala Leu Ala Gly Gln 
1               5                   10                  15      


Arg Gln Gly Thr Gln Ala Glu Ser Asn Leu Ser Ser Lys Phe Gln Phe 
            20                  25                  30          


Ser Ser Asn Lys Glu Gln Asn Gly Arg Asn Tyr Ile Gln Ala Ser Gly 
        35                  40                  45              


Leu Ala 
    50  


<210>  10183
<211>  282
<212>  PRT
<213>  Homo Sapiens

<400>  10183

Met Ser Leu Phe Gly Leu Leu Leu Leu Thr Ser Ala Leu Ala Gly Gln 
1               5                   10                  15      


Arg Gln Gly Thr Gln Ala Glu Ser Asn Leu Ser Ser Lys Phe Gln Phe 
            20                  25                  30          


Ser Ser Asn Lys Glu Gln Asn Gly Val Gln Asp Pro Gln His Glu Arg 
        35                  40                  45              


Ile Ile Thr Val Ser Thr Asn Gly Ser Ile His Ser Pro Arg Phe Pro 
    50                  55                  60                  


His Thr Tyr Pro Arg Asn Thr Val Leu Val Trp Arg Leu Val Ala Val 
65                  70                  75                  80  


Glu Glu Asn Val Trp Ile Gln Leu Thr Phe Asp Glu Arg Phe Gly Leu 
                85                  90                  95      


Glu Asp Pro Glu Asp Asp Ile Cys Lys Tyr Asp Phe Val Glu Val Glu 
            100                 105                 110         


Glu Pro Ser Asp Gly Thr Ile Leu Gly Arg Trp Cys Gly Ser Gly Thr 
        115                 120                 125             


Val Pro Gly Lys Gln Ile Ser Lys Gly Asn Gln Ile Arg Ile Arg Phe 
    130                 135                 140                 


Val Ser Asp Glu Tyr Phe Pro Ser Glu Pro Gly Phe Cys Ile His Tyr 
145                 150                 155                 160 


Asn Ile Val Met Pro Gln Phe Thr Glu Ala Val Ser Pro Ser Val Leu 
                165                 170                 175     


Pro Pro Ser Ala Leu Pro Leu Asp Leu Leu Asn Asn Ala Ile Thr Ala 
            180                 185                 190         


Phe Ser Thr Leu Glu Asp Leu Ile Arg Tyr Leu Glu Pro Glu Arg Trp 
        195                 200                 205             


Gln Leu Asp Leu Glu Asp Leu Tyr Arg Pro Thr Trp Gln Leu Leu Gly 
    210                 215                 220                 


Lys Ala Phe Val Phe Gly Arg Lys Ser Arg Val Val Asp Leu Asn Leu 
225                 230                 235                 240 


Leu Thr Glu Glu Val Leu Gln Leu Arg Pro Lys Thr Gly Val Arg Gly 
                245                 250                 255     


Leu His Lys Ser Leu Thr Asp Val Ala Leu Glu His His Glu Glu Cys 
            260                 265                 270         


Asp Cys Val Cys Arg Gly Ser Thr Gly Gly 
        275                 280         


<210>  10184
<211>  345
<212>  PRT
<213>  Homo Sapiens

<400>  10184

Met Ser Leu Phe Gly Leu Leu Leu Leu Thr Ser Ala Leu Ala Gly Gln 
1               5                   10                  15      


Arg Gln Gly Thr Gln Ala Glu Ser Asn Leu Ser Ser Lys Phe Gln Phe 
            20                  25                  30          


Ser Ser Asn Lys Glu Gln Asn Gly Val Gln Asp Pro Gln His Glu Arg 
        35                  40                  45              


Ile Ile Thr Val Ser Thr Asn Gly Ser Ile His Ser Pro Arg Phe Pro 
    50                  55                  60                  


His Thr Tyr Pro Arg Asn Thr Val Leu Val Trp Arg Leu Val Ala Val 
65                  70                  75                  80  


Glu Glu Asn Val Trp Ile Gln Leu Thr Phe Asp Glu Arg Phe Gly Leu 
                85                  90                  95      


Glu Asp Pro Glu Asp Asp Ile Cys Lys Tyr Asp Phe Val Glu Val Glu 
            100                 105                 110         


Glu Pro Ser Asp Gly Thr Ile Leu Gly Arg Trp Cys Gly Ser Gly Thr 
        115                 120                 125             


Val Pro Gly Lys Gln Ile Ser Lys Gly Asn Gln Ile Arg Ile Arg Phe 
    130                 135                 140                 


Val Ser Asp Glu Tyr Phe Pro Ser Glu Pro Gly Phe Cys Ile His Tyr 
145                 150                 155                 160 


Asn Ile Val Met Pro Gln Phe Thr Glu Ala Val Ser Pro Ser Val Leu 
                165                 170                 175     


Pro Pro Ser Ala Leu Pro Leu Asp Leu Leu Asn Asn Ala Ile Thr Ala 
            180                 185                 190         


Phe Ser Thr Leu Glu Asp Leu Ile Arg Tyr Leu Glu Pro Glu Arg Trp 
        195                 200                 205             


Gln Leu Asp Leu Glu Asp Leu Tyr Arg Pro Thr Trp Gln Leu Leu Gly 
    210                 215                 220                 


Lys Ala Phe Val Phe Gly Arg Lys Ser Arg Val Val Asp Leu Asn Leu 
225                 230                 235                 240 


Leu Thr Glu Glu Val Arg Leu Tyr Ser Cys Thr Pro Arg Asn Phe Ser 
                245                 250                 255     


Val Ser Ile Arg Glu Glu Leu Lys Arg Thr Asp Thr Ile Phe Trp Pro 
            260                 265                 270         


Gly Cys Leu Leu Val Lys Arg Cys Gly Gly Asn Cys Ala Cys Cys Leu 
        275                 280                 285             


His Asn Cys Asn Glu Cys Gln Cys Val Pro Ser Lys Val Thr Lys Lys 
    290                 295                 300                 


Tyr His Glu Val Leu Gln Leu Arg Pro Lys Thr Gly Val Arg Gly Leu 
305                 310                 315                 320 


His Lys Ser Leu Thr Asp Val Ala Leu Glu His His Glu Glu Cys Asp 
                325                 330                 335     


Cys Val Cys Arg Gly Ser Thr Gly Gly 
            340                 345 


<210>  10185
<211>  53
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  10185

Xaa Thr Phe Asp Glu Arg Phe Gly Leu Glu Asp Pro Glu Asp Asp Ile 
1               5                   10                  15      


Cys Lys Tyr Asp Phe Val Glu Val Glu Glu Pro Ser Asp Gly Thr Ile 
            20                  25                  30          


Leu Gly Arg Trp Cys Gly Ser Gly Phe Cys Ile His Tyr Asn Ile Val 
        35                  40                  45              


Met Pro Asn Leu Pro 
    50              


<210>  10186
<211>  206
<212>  PRT
<213>  Homo Sapiens

<400>  10186

Ile Phe Glu Ala Val Gly Ala Gln Gly Thr Val Val Leu Asp Glu Glu 
1               5                   10                  15      


Ser Leu His Val Asp Asp Leu Asp Leu Phe Asp Gly Asp Ser Gly Leu 
            20                  25                  30          


Arg Phe Ala Glu Asp Leu Glu Val Ser Glu Leu Lys Val Gly Ala Asp 
        35                  40                  45              


Leu Glu Arg Glu Gly Asp Leu Gly Glu Val Pro Pro His Ala Val His 
    50                  55                  60                  


Glu Ser Asn His Leu Thr Asp Leu Tyr Arg Arg Asp Glu Thr Ile Gln 
65                  70                  75                  80  


Val Lys Gly Asn Gly Tyr Val Gln Ser Pro Arg Phe Pro Asn Ser Tyr 
                85                  90                  95      


Pro Arg Asn Leu Leu Leu Thr Trp Arg Leu His Ser Gln Glu Asn Thr 
            100                 105                 110         


Arg Ile Gln Leu Val Phe Asp Asn Gln Phe Gly Leu Glu Glu Ala Glu 
        115                 120                 125             


Asn Asp Ile Cys Arg Tyr Asp Phe Val Glu Val Glu Asp Ile Ser Glu 
    130                 135                 140                 


Thr Ser Thr Ile Ile Arg Gly Arg Trp Cys Gly His Lys Glu Val Pro 
145                 150                 155                 160 


Pro Arg Ile Lys Ser Arg Thr Asn Gln Ile Lys Ile Thr Phe Lys Ser 
                165                 170                 175     


Asp Asp Tyr Phe Val Ala Lys Pro Gly Phe Lys Ile Tyr Tyr Ser Leu 
            180                 185                 190         


Leu Glu Asp Phe Gln Pro Ala Ala Ala Ser Glu Thr Asn Trp 
        195                 200                 205     


<210>  10187
<211>  364
<212>  PRT
<213>  Homo Sapiens

<400>  10187

Met His Arg Leu Ile Phe Val Tyr Thr Leu Ile Cys Ala Asn Phe Cys 
1               5                   10                  15      


Ser Cys Arg Asp Thr Ser Ala Thr Pro Gln Ser Ala Ser Ile Lys Ala 
            20                  25                  30          


Leu Arg Asn Ala Asn Leu Arg Arg Asp Asp Leu Tyr Arg Arg Asp Glu 
        35                  40                  45              


Thr Ile Gln Val Lys Gly Asn Gly Tyr Val Gln Ser Pro Arg Phe Pro 
    50                  55                  60                  


Asn Ser Tyr Pro Arg Asn Leu Leu Leu Thr Trp Arg Leu His Ser Gln 
65                  70                  75                  80  


Glu Asn Thr Arg Ile Gln Leu Val Phe Asp Asn Gln Phe Gly Leu Glu 
                85                  90                  95      


Glu Ala Glu Asn Asp Ile Cys Arg Tyr Asp Phe Val Glu Val Glu Asp 
            100                 105                 110         


Ile Ser Glu Thr Ser Thr Ile Ile Arg Gly Arg Trp Cys Gly His Lys 
        115                 120                 125             


Glu Val Pro Pro Arg Ile Lys Ser Arg Thr Asn Gln Ile Lys Ile Thr 
    130                 135                 140                 


Phe Lys Ser Asp Asp Tyr Phe Val Ala Lys Pro Gly Phe Lys Ile Tyr 
145                 150                 155                 160 


Tyr Ser Leu Leu Glu Asp Phe Gln Pro Ala Ala Ala Ser Glu Thr Asn 
                165                 170                 175     


Trp Glu Ser Val Thr Ser Ser Ile Ser Gly Val Ser Tyr Asn Ser Pro 
            180                 185                 190         


Ser Val Thr Asp Pro Thr Leu Ile Ala Asp Ala Leu Asp Lys Lys Ile 
        195                 200                 205             


Ala Glu Phe Asp Thr Val Glu Asp Leu Leu Lys Tyr Phe Asn Pro Glu 
    210                 215                 220                 


Ser Trp Gln Glu Asp Leu Glu Asn Met Tyr Leu Asp Thr Pro Arg Tyr 
225                 230                 235                 240 


Arg Gly Arg Ser Tyr His Asp Arg Lys Ser Lys Val Asp Leu Asp Arg 
                245                 250                 255     


Leu Asn Asp Asp Ala Lys Arg Tyr Ser Cys Thr Pro Arg Asn Tyr Ser 
            260                 265                 270         


Val Asn Ile Arg Glu Glu Leu Lys Leu Ala Asn Val Val Phe Phe Pro 
        275                 280                 285             


Arg Cys Leu Leu Val Gln Arg Cys Gly Gly Asn Cys Gly Cys Gly Thr 
    290                 295                 300                 


Val Asn Trp Arg Ser Cys Thr Cys Asn Ser Gly Lys Thr Val Lys Lys 
305                 310                 315                 320 


Tyr His Glu Val Leu Gln Phe Glu Pro Gly His Ile Lys Arg Arg Gly 
                325                 330                 335     


Arg Ala Lys Thr Met Ala Leu Val Asp Ile Gln Leu Asp His His Glu 
            340                 345                 350         


Arg Cys Asp Cys Ile Cys Ser Ser Arg Pro Pro Arg 
        355                 360                 


<210>  10188
<211>  370
<212>  PRT
<213>  Homo Sapiens

<400>  10188

Met His Arg Leu Ile Phe Val Tyr Thr Leu Ile Cys Ala Asn Phe Cys 
1               5                   10                  15      


Ser Cys Arg Asp Thr Ser Ala Thr Pro Gln Ser Ala Ser Ile Lys Ala 
            20                  25                  30          


Leu Arg Asn Ala Asn Leu Arg Arg Asp Glu Ser Asn His Leu Thr Asp 
        35                  40                  45              


Leu Tyr Arg Arg Asp Glu Thr Ile Gln Val Lys Gly Asn Gly Tyr Val 
    50                  55                  60                  


Gln Ser Pro Arg Phe Pro Asn Ser Tyr Pro Arg Asn Leu Leu Leu Thr 
65                  70                  75                  80  


Trp Arg Leu His Ser Gln Glu Asn Thr Arg Ile Gln Leu Val Phe Asp 
                85                  90                  95      


Asn Gln Phe Gly Leu Glu Glu Ala Glu Asn Asp Ile Cys Arg Tyr Asp 
            100                 105                 110         


Phe Val Glu Val Glu Asp Ile Ser Glu Thr Ser Thr Ile Ile Arg Gly 
        115                 120                 125             


Arg Trp Cys Gly His Lys Glu Val Pro Pro Arg Ile Lys Ser Arg Thr 
    130                 135                 140                 


Asn Gln Ile Lys Ile Thr Phe Lys Ser Asp Asp Tyr Phe Val Ala Lys 
145                 150                 155                 160 


Pro Gly Phe Lys Ile Tyr Tyr Ser Leu Leu Glu Asp Phe Gln Pro Ala 
                165                 170                 175     


Ala Ala Ser Glu Thr Asn Trp Glu Ser Val Thr Ser Ser Ile Ser Gly 
            180                 185                 190         


Val Ser Tyr Asn Ser Pro Ser Val Thr Asp Pro Thr Leu Ile Ala Asp 
        195                 200                 205             


Ala Leu Asp Lys Lys Ile Ala Glu Phe Asp Thr Val Glu Asp Leu Leu 
    210                 215                 220                 


Lys Tyr Phe Asn Pro Glu Ser Trp Gln Glu Asp Leu Glu Asn Met Tyr 
225                 230                 235                 240 


Leu Asp Thr Pro Arg Tyr Arg Gly Arg Ser Tyr His Asp Arg Lys Ser 
                245                 250                 255     


Lys Val Asp Leu Asp Arg Leu Asn Asp Asp Ala Lys Arg Tyr Ser Cys 
            260                 265                 270         


Thr Pro Arg Asn Tyr Ser Val Asn Ile Arg Glu Glu Leu Lys Leu Ala 
        275                 280                 285             


Asn Val Val Phe Phe Pro Arg Cys Leu Leu Val Gln Arg Cys Gly Gly 
    290                 295                 300                 


Asn Cys Gly Cys Gly Thr Val Asn Trp Arg Ser Cys Thr Cys Asn Ser 
305                 310                 315                 320 


Gly Lys Thr Val Lys Lys Tyr His Glu Val Leu Gln Phe Glu Pro Gly 
                325                 330                 335     


His Ile Lys Arg Arg Gly Arg Ala Lys Thr Met Ala Leu Val Asp Ile 
            340                 345                 350         


Gln Leu Asp His His Glu Arg Cys Asp Cys Ile Cys Ser Ser Arg Pro 
        355                 360                 365             


Pro Arg 
    370 


<210>  10189
<211>  154
<212>  PRT
<213>  Homo Sapiens

<400>  10189

Met Gly Thr Ser His Pro Ala Phe Leu Val Leu Gly Cys Leu Leu Thr 
1               5                   10                  15      


Gly Leu Ser Leu Ile Leu Cys Gln Leu Ser Leu Pro Ser Ile Leu Pro 
            20                  25                  30          


Asn Glu Asn Glu Lys Val Val Gln Leu Asn Ser Ser Phe Ser Leu Arg 
        35                  40                  45              


Cys Phe Gly Glu Ser Glu Val Ser Trp Gln Tyr Pro Met Ser Glu Glu 
    50                  55                  60                  


Glu Ser Ser Asp Val Glu Ile Arg Asn Glu Glu Asn Asn Ser Gly Leu 
65                  70                  75                  80  


Phe Val Thr Val Leu Glu Val Ser Ser Ala Ser Ala Ala His Thr Gly 
                85                  90                  95      


Leu Tyr Thr Cys Tyr Tyr Asn His Thr Gln Thr Glu Glu Asn Glu Leu 
            100                 105                 110         


Glu Gly Arg His Ile Tyr Ile Tyr Val Pro Asp Pro Asp Val Ala Phe 
        115                 120                 125             


Val Pro Leu Gly Met Thr Asp Tyr Leu Val Ile Val Glu Asp Asp Asp 
    130                 135                 140                 


Ser Ala Ile Ile Pro Cys Arg Thr Thr Asp 
145                 150                 


<210>  10190
<211>  158
<212>  PRT
<213>  Homo Sapiens

<400>  10190

Met Gly Thr Ser His Pro Ala Phe Leu Val Leu Gly Cys Leu Leu Thr 
1               5                   10                  15      


Gly Leu Ser Leu Ile Leu Cys Gln Leu Ser Leu Pro Ser Ile Leu Pro 
            20                  25                  30          


Asn Glu Asn Glu Lys Val Val Gln Leu Asn Ser Ser Phe Ser Leu Arg 
        35                  40                  45              


Cys Phe Gly Glu Ser Glu Val Ser Trp Gln Tyr Pro Met Ser Glu Glu 
    50                  55                  60                  


Glu Ser Ser Asp Val Glu Ile Arg Asn Glu Glu Asn Asn Ser Gly Leu 
65                  70                  75                  80  


Phe Val Thr Val Leu Glu Val Ser Ser Ala Ser Ala Ala His Thr Gly 
                85                  90                  95      


Leu Tyr Thr Cys Tyr Tyr Asn His Thr Gln Thr Glu Glu Asn Glu Leu 
            100                 105                 110         


Glu Gly Arg His Ile Tyr Ile Tyr Val Pro Asp Pro Asp Val Ala Phe 
        115                 120                 125             


Val Pro Leu Gly Met Thr Asp Tyr Leu Val Ile Val Glu Asp Asp Asp 
    130                 135                 140                 


Ser Ala Ile Ile Pro Cys Arg Thr Thr Asp Pro Glu Thr Pro 
145                 150                 155             


<210>  10191
<211>  159
<212>  PRT
<213>  Homo Sapiens

<400>  10191

Met Gly Thr Ser His Pro Ala Phe Leu Val Leu Gly Cys Leu Leu Thr 
1               5                   10                  15      


Gly Leu Ser Leu Ile Leu Cys Gln Leu Ser Leu Pro Ser Ile Leu Pro 
            20                  25                  30          


Asn Glu Asn Glu Lys Val Val Gln Leu Asn Ser Ser Phe Ser Leu Arg 
        35                  40                  45              


Cys Phe Gly Glu Ser Glu Val Ser Trp Gln Tyr Pro Met Ser Glu Glu 
    50                  55                  60                  


Glu Ser Ser Asp Val Glu Ile Arg Asn Glu Glu Asn Asn Ser Gly Leu 
65                  70                  75                  80  


Phe Val Thr Val Leu Glu Val Ser Ser Ala Ser Ala Ala His Thr Gly 
                85                  90                  95      


Leu Tyr Thr Cys Tyr Tyr Asn His Thr Gln Thr Glu Glu Asn Glu Leu 
            100                 105                 110         


Glu Gly Arg His Ile Tyr Ile Tyr Val Pro Asp Pro Asp Val Ala Phe 
        115                 120                 125             


Val Pro Leu Gly Met Thr Asp Tyr Leu Val Ile Val Glu Asp Asp Asp 
    130                 135                 140                 


Ser Ala Ile Ile Pro Cys Arg Thr Thr Asp Pro Glu Thr Pro Val 
145                 150                 155                 


<210>  10192
<211>  1089
<212>  PRT
<213>  Homo Sapiens

<400>  10192

Met Gly Thr Ser His Pro Ala Phe Leu Val Leu Gly Cys Leu Leu Thr 
1               5                   10                  15      


Gly Leu Ser Leu Ile Leu Cys Gln Leu Ser Leu Pro Ser Ile Leu Pro 
            20                  25                  30          


Asn Glu Asn Glu Lys Val Val Gln Leu Asn Ser Ser Phe Ser Leu Arg 
        35                  40                  45              


Cys Phe Gly Glu Ser Glu Val Ser Trp Gln Tyr Pro Met Ser Glu Glu 
    50                  55                  60                  


Glu Ser Ser Asp Val Glu Ile Arg Asn Glu Glu Asn Asn Ser Gly Leu 
65                  70                  75                  80  


Phe Val Thr Val Leu Glu Val Ser Ser Ala Ser Ala Ala His Thr Gly 
                85                  90                  95      


Leu Tyr Thr Cys Tyr Tyr Asn His Thr Gln Thr Glu Glu Asn Glu Leu 
            100                 105                 110         


Glu Gly Arg His Ile Tyr Ile Tyr Val Pro Asp Pro Asp Val Ala Phe 
        115                 120                 125             


Val Pro Leu Gly Met Thr Asp Tyr Leu Val Ile Val Glu Asp Asp Asp 
    130                 135                 140                 


Ser Ala Ile Ile Pro Cys Arg Thr Thr Asp Pro Glu Thr Pro Val Thr 
145                 150                 155                 160 


Leu His Asn Ser Glu Gly Val Val Pro Ala Ser Tyr Asp Ser Arg Gln 
                165                 170                 175     


Gly Phe Asn Gly Thr Phe Thr Val Gly Pro Tyr Ile Cys Glu Ala Thr 
            180                 185                 190         


Val Lys Gly Lys Lys Phe Gln Thr Ile Pro Phe Asn Val Tyr Ala Leu 
        195                 200                 205             


Lys Ala Thr Ser Glu Leu Asp Leu Glu Met Glu Ala Leu Lys Thr Val 
    210                 215                 220                 


Tyr Lys Ser Gly Glu Thr Ile Val Val Thr Cys Ala Val Phe Asn Asn 
225                 230                 235                 240 


Glu Val Val Asp Leu Gln Trp Thr Tyr Pro Gly Glu Val Lys Gly Lys 
                245                 250                 255     


Gly Ile Thr Met Leu Glu Glu Ile Lys Val Pro Ser Ile Lys Leu Val 
            260                 265                 270         


Tyr Thr Leu Thr Val Pro Glu Ala Thr Val Lys Asp Ser Gly Asp Tyr 
        275                 280                 285             


Glu Cys Ala Ala Arg Gln Ala Thr Arg Glu Val Lys Glu Met Lys Lys 
    290                 295                 300                 


Val Thr Ile Ser Val His Glu Lys Gly Phe Ile Glu Ile Lys Pro Thr 
305                 310                 315                 320 


Phe Ser Gln Leu Glu Ala Val Asn Leu His Glu Val Lys His Phe Val 
                325                 330                 335     


Val Glu Val Arg Ala Tyr Pro Pro Pro Arg Ile Ser Trp Leu Lys Asn 
            340                 345                 350         


Asn Leu Thr Leu Ile Glu Asn Leu Thr Glu Ile Thr Thr Asp Val Glu 
        355                 360                 365             


Lys Ile Gln Glu Ile Arg Tyr Arg Ser Lys Leu Lys Leu Ile Arg Ala 
    370                 375                 380                 


Lys Glu Glu Asp Ser Gly His Tyr Thr Ile Val Ala Gln Asn Glu Asp 
385                 390                 395                 400 


Ala Val Lys Ser Tyr Thr Phe Glu Leu Leu Thr Gln Val Pro Ser Ser 
                405                 410                 415     


Ile Leu Asp Leu Val Asp Asp His His Gly Ser Thr Gly Gly Gln Thr 
            420                 425                 430         


Val Arg Cys Thr Ala Glu Gly Thr Pro Leu Pro Asp Ile Glu Trp Met 
        435                 440                 445             


Ile Cys Lys Asp Ile Lys Lys Cys Asn Asn Glu Thr Ser Trp Thr Ile 
    450                 455                 460                 


Leu Ala Asn Asn Val Ser Asn Ile Ile Thr Glu Ile His Ser Arg Asp 
465                 470                 475                 480 


Arg Ser Thr Val Glu Gly Arg Val Thr Phe Ala Lys Val Glu Glu Thr 
                485                 490                 495     


Ile Ala Val Arg Cys Leu Ala Lys Asn Leu Leu Gly Ala Glu Asn Arg 
            500                 505                 510         


Glu Leu Lys Leu Val Ala Pro Thr Leu Arg Ser Glu Leu Thr Val Ala 
        515                 520                 525             


Ala Ala Val Leu Val Leu Leu Val Ile Val Ile Ile Ser Leu Ile Val 
    530                 535                 540                 


Leu Val Val Ile Trp Lys Gln Lys Pro Arg Tyr Glu Ile Arg Trp Arg 
545                 550                 555                 560 


Val Ile Glu Ser Ile Ser Pro Asp Gly His Glu Tyr Ile Tyr Val Asp 
                565                 570                 575     


Pro Met Gln Leu Pro Tyr Asp Ser Arg Trp Glu Phe Pro Arg Asp Gly 
            580                 585                 590         


Leu Val Leu Gly Arg Val Leu Gly Ser Gly Ala Phe Gly Lys Val Val 
        595                 600                 605             


Glu Gly Thr Ala Tyr Gly Leu Ser Arg Ser Gln Pro Val Met Lys Val 
    610                 615                 620                 


Ala Val Lys Met Leu Lys Pro Thr Ala Arg Ser Ser Glu Lys Gln Ala 
625                 630                 635                 640 


Leu Met Ser Glu Leu Lys Ile Met Thr His Leu Gly Pro His Leu Asn 
                645                 650                 655     


Ile Val Asn Leu Leu Gly Ala Cys Thr Lys Ser Gly Pro Ile Tyr Ile 
            660                 665                 670         


Ile Thr Glu Tyr Cys Phe Tyr Gly Asp Leu Val Asn Tyr Leu His Lys 
        675                 680                 685             


Asn Arg Asp Ser Phe Leu Ser His His Pro Glu Lys Pro Lys Lys Glu 
    690                 695                 700                 


Leu Asp Ile Phe Gly Leu Asn Pro Ala Asp Glu Ser Thr Arg Ser Tyr 
705                 710                 715                 720 


Val Ile Leu Ser Phe Glu Asn Asn Gly Asp Tyr Met Asp Met Lys Gln 
                725                 730                 735     


Ala Asp Thr Thr Gln Tyr Val Pro Met Leu Glu Arg Lys Glu Val Ser 
            740                 745                 750         


Lys Tyr Ser Asp Ile Gln Arg Ser Leu Tyr Asp Arg Pro Ala Ser Tyr 
        755                 760                 765             


Lys Lys Lys Ser Met Leu Asp Ser Glu Val Lys Asn Leu Leu Ser Asp 
    770                 775                 780                 


Asp Asn Ser Glu Gly Leu Thr Leu Leu Asp Leu Leu Ser Phe Thr Tyr 
785                 790                 795                 800 


Gln Val Ala Arg Gly Met Glu Phe Leu Ala Ser Lys Asn Cys Val His 
                805                 810                 815     


Arg Asp Leu Ala Ala Arg Asn Val Leu Leu Ala Gln Gly Lys Ile Val 
            820                 825                 830         


Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp Ile Met His Asp Ser Asn 
        835                 840                 845             


Tyr Val Ser Lys Gly Ser Thr Phe Leu Pro Val Lys Trp Met Ala Pro 
    850                 855                 860                 


Glu Ser Ile Phe Asp Asn Leu Tyr Thr Thr Leu Ser Asp Val Trp Ser 
865                 870                 875                 880 


Tyr Gly Ile Leu Leu Trp Glu Ile Phe Ser Leu Gly Gly Thr Pro Tyr 
                885                 890                 895     


Pro Gly Met Met Val Asp Ser Thr Phe Tyr Asn Lys Ile Lys Ser Gly 
            900                 905                 910         


Tyr Arg Met Ala Lys Pro Asp His Ala Thr Ser Glu Val Tyr Glu Ile 
        915                 920                 925             


Met Val Lys Cys Trp Asn Ser Glu Pro Glu Lys Arg Pro Ser Phe Tyr 
    930                 935                 940                 


His Leu Ser Glu Ile Val Glu Asn Leu Leu Pro Gly Gln Tyr Lys Lys 
945                 950                 955                 960 


Ser Tyr Glu Lys Ile His Leu Asp Phe Leu Lys Ser Asp His Pro Ala 
                965                 970                 975     


Val Ala Arg Met Arg Val Asp Ser Asp Asn Ala Tyr Ile Gly Val Thr 
            980                 985                 990         


Tyr Lys Asn Glu Glu Asp Lys Leu  Lys Asp Trp Glu Gly  Gly Leu Asp 
        995                 1000                 1005             


Glu Gln  Arg Leu Ser Ala Asp  Ser Gly Tyr Ile Ile  Pro Leu Pro 
    1010                 1015                 1020             


Asp Ile  Asp Pro Val Pro Glu  Glu Glu Asp Leu Gly  Lys Arg Asn 
    1025                 1030                 1035             


Arg His  Ser Ser Gln Thr Ser  Glu Glu Ser Ala Ile  Glu Thr Gly 
    1040                 1045                 1050             


Ser Ser  Ser Ser Thr Phe Ile  Lys Arg Glu Asp Glu  Thr Ile Glu 
    1055                 1060                 1065             


Asp Ile  Asp Met Met Asp Asp  Ile Gly Ile Asp Ser  Ser Asp Leu 
    1070                 1075                 1080             


Val Glu  Asp Ser Phe Leu 
    1085                 


<210>  10193
<211>  743
<212>  PRT
<213>  Homo Sapiens

<400>  10193

Met Gly Thr Ser His Pro Ala Phe Leu Val Leu Gly Cys Leu Leu Thr 
1               5                   10                  15      


Gly Leu Ser Leu Ile Leu Cys Gln Leu Ser Leu Pro Ser Ile Leu Pro 
            20                  25                  30          


Asn Glu Asn Glu Lys Val Val Gln Leu Asn Ser Ser Phe Ser Leu Arg 
        35                  40                  45              


Cys Phe Gly Glu Ser Glu Val Ser Trp Gln Tyr Pro Met Ser Glu Glu 
    50                  55                  60                  


Glu Ser Ser Asp Val Glu Ile Arg Asn Glu Glu Asn Asn Ser Gly Leu 
65                  70                  75                  80  


Phe Val Thr Val Leu Glu Val Ser Ser Ala Ser Ala Ala His Thr Gly 
                85                  90                  95      


Leu Tyr Thr Cys Tyr Tyr Asn His Thr Gln Thr Glu Glu Asn Glu Leu 
            100                 105                 110         


Glu Gly Arg His Ile Tyr Ile Tyr Val Pro Asp Pro Asp Val Ala Phe 
        115                 120                 125             


Val Pro Leu Gly Met Thr Asp Tyr Leu Val Ile Val Glu Asp Asp Asp 
    130                 135                 140                 


Ser Ala Ile Ile Pro Cys Arg Thr Thr Asp Pro Glu Thr Pro Val Thr 
145                 150                 155                 160 


Leu His Asn Ser Glu Gly Val Val Pro Ala Ser Tyr Asp Ser Arg Gln 
                165                 170                 175     


Gly Phe Asn Gly Thr Phe Thr Val Gly Pro Tyr Ile Cys Glu Ala Thr 
            180                 185                 190         


Val Lys Gly Lys Lys Phe Gln Thr Ile Pro Phe Asn Val Tyr Ala Leu 
        195                 200                 205             


Lys Ala Thr Ser Glu Leu Asp Leu Glu Met Glu Ala Leu Lys Thr Val 
    210                 215                 220                 


Tyr Lys Ser Gly Glu Thr Ile Val Val Thr Cys Ala Val Phe Asn Asn 
225                 230                 235                 240 


Glu Val Val Asp Leu Gln Trp Thr Tyr Pro Gly Glu Val Lys Gly Lys 
                245                 250                 255     


Gly Ile Thr Met Leu Glu Glu Ile Lys Val Pro Ser Ile Lys Leu Val 
            260                 265                 270         


Tyr Thr Leu Thr Val Pro Glu Ala Thr Val Lys Asp Ser Gly Asp Tyr 
        275                 280                 285             


Glu Cys Ala Ala Arg Gln Ala Thr Arg Glu Val Lys Glu Met Lys Lys 
    290                 295                 300                 


Val Thr Ile Ser Val His Glu Lys Gly Phe Ile Glu Ile Lys Pro Thr 
305                 310                 315                 320 


Phe Ser Gln Leu Glu Ala Val Asn Leu His Glu Val Lys His Phe Val 
                325                 330                 335     


Val Glu Val Arg Ala Tyr Pro Pro Pro Arg Ile Ser Trp Leu Lys Asn 
            340                 345                 350         


Asn Leu Thr Leu Ile Glu Asn Leu Thr Glu Ile Thr Thr Asp Val Glu 
        355                 360                 365             


Lys Ile Gln Glu Ile Arg Tyr Arg Ser Lys Leu Lys Leu Ile Arg Ala 
    370                 375                 380                 


Lys Glu Glu Asp Ser Gly His Tyr Thr Ile Val Ala Gln Asn Glu Asp 
385                 390                 395                 400 


Ala Val Lys Ser Tyr Thr Phe Glu Leu Leu Thr Gln Val Pro Ser Ser 
                405                 410                 415     


Ile Leu Asp Leu Val Asp Asp His His Gly Ser Thr Gly Gly Gln Thr 
            420                 425                 430         


Val Arg Cys Thr Ala Glu Gly Thr Pro Leu Pro Asp Ile Glu Trp Met 
        435                 440                 445             


Ile Cys Lys Asp Ile Lys Lys Cys Asn Asn Glu Thr Ser Trp Thr Ile 
    450                 455                 460                 


Leu Ala Asn Asn Val Ser Asn Ile Ile Thr Glu Ile His Ser Arg Asp 
465                 470                 475                 480 


Arg Ser Thr Val Glu Gly Arg Val Thr Phe Ala Lys Val Glu Glu Thr 
                485                 490                 495     


Ile Ala Val Arg Cys Leu Ala Lys Asn Leu Leu Gly Ala Glu Asn Arg 
            500                 505                 510         


Glu Leu Lys Leu Val Ala Pro Thr Leu Arg Ser Glu Leu Thr Val Ala 
        515                 520                 525             


Ala Ala Val Leu Val Leu Leu Val Ile Val Ile Ile Ser Leu Ile Val 
    530                 535                 540                 


Leu Val Val Ile Trp Lys Gln Lys Pro Arg Tyr Glu Ile Arg Trp Arg 
545                 550                 555                 560 


Val Ile Glu Ser Ile Ser Pro Asp Gly His Glu Tyr Ile Tyr Val Asp 
                565                 570                 575     


Pro Met Gln Leu Pro Tyr Asp Ser Arg Trp Glu Phe Pro Arg Asp Gly 
            580                 585                 590         


Leu Val Leu Gly Arg Val Leu Gly Ser Gly Ala Phe Gly Lys Val Val 
        595                 600                 605             


Glu Gly Thr Ala Tyr Gly Leu Ser Arg Ser Gln Pro Val Met Lys Val 
    610                 615                 620                 


Ala Val Lys Met Leu Lys Pro Thr Ala Arg Ser Ser Glu Lys Gln Ala 
625                 630                 635                 640 


Leu Met Ser Glu Leu Lys Ile Met Thr His Leu Gly Pro His Leu Asn 
                645                 650                 655     


Ile Val Asn Leu Leu Gly Ala Cys Thr Lys Ser Gly Pro Ile Tyr Ile 
            660                 665                 670         


Ile Thr Glu Tyr Cys Phe Tyr Gly Asp Leu Val Asn Tyr Leu His Lys 
        675                 680                 685             


Asn Arg Asp Ser Phe Leu Ser His His Pro Glu Lys Pro Lys Lys Glu 
    690                 695                 700                 


Leu Asp Ile Phe Gly Leu Asn Pro Ala Asp Glu Ser Thr Arg Ser Ser 
705                 710                 715                 720 


Gly Gln Gly Cys Leu Ser Ser Gly Thr Leu Gln Glu Leu Ser Val Asp 
                725                 730                 735     


Leu Gln Ala Arg Gly Pro Cys 
            740             


<210>  10194
<211>  218
<212>  PRT
<213>  Homo Sapiens

<400>  10194

Met Gly Thr Ser His Pro Ala Phe Leu Val Leu Gly Cys Leu Leu Thr 
1               5                   10                  15      


Gly Leu Ser Leu Ile Leu Cys Gln Leu Ser Leu Pro Ser Ile Leu Pro 
            20                  25                  30          


Asn Glu Asn Glu Lys Val Val Gln Leu Asn Ser Ser Phe Ser Leu Arg 
        35                  40                  45              


Cys Phe Gly Glu Ser Glu Val Ser Trp Gln Tyr Pro Met Ser Glu Glu 
    50                  55                  60                  


Glu Ser Ser Asp Val Glu Ile Arg Asn Glu Glu Asn Asn Ser Gly Leu 
65                  70                  75                  80  


Phe Val Thr Val Leu Glu Val Ser Ser Ala Ser Ala Ala His Thr Gly 
                85                  90                  95      


Leu Tyr Thr Cys Tyr Tyr Asn His Thr Gln Thr Glu Glu Asn Glu Leu 
            100                 105                 110         


Glu Gly Arg His Ile Tyr Ile Tyr Val Pro Asp Pro Asp Val Ala Phe 
        115                 120                 125             


Val Pro Leu Gly Met Thr Asp Tyr Leu Val Ile Val Glu Asp Asp Asp 
    130                 135                 140                 


Ser Ala Ile Ile Pro Cys Arg Thr Thr Asp Pro Glu Thr Pro Val Thr 
145                 150                 155                 160 


Leu His Asn Ser Glu Gly Val Val Pro Ala Ser Tyr Asp Ser Arg Gln 
                165                 170                 175     


Gly Phe Asn Gly Thr Phe Thr Val Gly Pro Tyr Ile Cys Glu Ala Thr 
            180                 185                 190         


Val Lys Gly Lys Lys Phe Gln Thr Ile Pro Phe Asn Val Tyr Ala Leu 
        195                 200                 205             


Lys Gly Thr Cys Ile Ile Ser Phe Leu Leu 
    210                 215             


<210>  10195
<211>  147
<212>  PRT
<213>  Homo Sapiens

<400>  10195

Met Leu Pro Arg Leu Val Leu Asn Ser Trp Ala Gln Met Ile Cys Leu 
1               5                   10                  15      


Pro Gln Leu Pro Lys Phe Pro Arg Ala Met Gly Thr Ser His Pro Ala 
            20                  25                  30          


Phe Leu Val Leu Gly Cys Leu Leu Thr Gly Leu Ser Leu Ile Leu Cys 
        35                  40                  45              


Gln Leu Ser Leu Pro Ser Ile Leu Pro Asn Glu Asn Glu Lys Val Val 
    50                  55                  60                  


Gln Leu Asn Ser Ser Phe Ser Leu Arg Cys Phe Gly Glu Ser Glu Val 
65                  70                  75                  80  


Ser Trp Gln Tyr Pro Met Ser Glu Glu Glu Ser Ser Asp Val Glu Ile 
                85                  90                  95      


Arg Asn Glu Glu Asn Asn Ser Gly Leu Phe Val Thr Val Leu Glu Val 
            100                 105                 110         


Ser Ser Ala Ser Ala Ala His Thr Gly Leu Tyr Thr Cys Tyr Tyr Asn 
        115                 120                 125             


His Thr Gln Thr Glu Glu Asn Glu Leu Glu Gly Arg His Ile Tyr Ile 
    130                 135                 140                 


Tyr Val Pro 
145         


<210>  10196
<211>  174
<212>  PRT
<213>  Homo Sapiens

<400>  10196

Met Arg Leu Pro Gly Ala Met Pro Ala Leu Ala Leu Lys Gly Glu Leu 
1               5                   10                  15      


Leu Leu Leu Ser Leu Leu Leu Leu Leu Glu Pro Gln Ile Ser Gln Gly 
            20                  25                  30          


Leu Val Val Thr Pro Pro Gly Pro Glu Leu Val Leu Asn Val Ser Ser 
        35                  40                  45              


Thr Phe Val Leu Thr Cys Ser Gly Ser Ala Pro Val Val Trp Glu Arg 
    50                  55                  60                  


Met Ser Gln Glu Pro Pro Gln Glu Met Ala Lys Ala Gln Asp Gly Thr 
65                  70                  75                  80  


Phe Ser Ser Val Leu Thr Leu Thr Asn Leu Thr Gly Leu Asp Thr Gly 
                85                  90                  95      


Glu Tyr Phe Cys Thr His Asn Asp Ser Arg Gly Leu Glu Thr Asp Glu 
            100                 105                 110         


Arg Lys Arg Leu Tyr Ile Phe Val Pro Asp Pro Thr Val Gly Phe Leu 
        115                 120                 125             


Pro Asn Asp Ala Glu Glu Leu Phe Ile Phe Leu Thr Glu Ile Thr Glu 
    130                 135                 140                 


Ile Thr Ile Pro Cys Arg Val Thr Asp Pro Gln Leu Val Val Thr Leu 
145                 150                 155                 160 


His Glu Lys Lys Gly Asp Val Ala Leu Pro Val Pro Tyr Asp 
                165                 170                 


<210>  10197
<211>  239
<212>  PRT
<213>  Homo Sapiens

<400>  10197

Met Arg Leu Pro Gly Ala Met Pro Ala Leu Ala Leu Lys Gly Glu Leu 
1               5                   10                  15      


Leu Leu Leu Ser Leu Leu Leu Leu Leu Glu Pro Gln Ile Ser Gln Gly 
            20                  25                  30          


Leu Val Val Thr Pro Pro Gly Pro Glu Leu Val Leu Asn Val Ser Ser 
        35                  40                  45              


Thr Phe Val Leu Thr Cys Ser Gly Ser Ala Pro Val Val Trp Glu Arg 
    50                  55                  60                  


Met Ser Gln Glu Pro Pro Gln Glu Met Ala Lys Ala Gln Asp Gly Thr 
65                  70                  75                  80  


Phe Ser Ser Val Leu Thr Leu Thr Asn Leu Thr Gly Leu Asp Thr Gly 
                85                  90                  95      


Glu Tyr Phe Cys Thr His Asn Asp Ser Arg Gly Leu Glu Thr Asp Glu 
            100                 105                 110         


Arg Lys Arg Leu Tyr Ile Phe Val Pro Asp Pro Thr Val Gly Phe Leu 
        115                 120                 125             


Pro Asn Asp Ala Glu Glu Leu Phe Ile Phe Leu Thr Glu Ile Thr Glu 
    130                 135                 140                 


Ile Thr Ile Pro Cys Arg Val Thr Asp Pro Gln Leu Val Val Thr Leu 
145                 150                 155                 160 


His Glu Lys Lys Gly Asp Val Ala Leu Pro Val Pro Tyr Asp His Gln 
                165                 170                 175     


Arg Gly Phe Ser Gly Ile Phe Glu Asp Arg Ser Tyr Ile Cys Lys Thr 
            180                 185                 190         


Thr Ile Gly Asp Arg Glu Val Asp Ser Asp Ala Tyr Tyr Val Tyr Arg 
        195                 200                 205             


Leu Gln Gly Glu Pro Pro Phe Trp Pro Asp Ala Gln Gln Ser Val Ile 
    210                 215                 220                 


His Gln Arg Leu Cys Glu Arg Ser Ala Asp Cys Gly Pro Pro Gly 
225                 230                 235                 


<210>  10198
<211>  1106
<212>  PRT
<213>  Homo Sapiens

<400>  10198

Met Arg Leu Pro Gly Ala Met Pro Ala Leu Ala Leu Lys Gly Glu Leu 
1               5                   10                  15      


Leu Leu Leu Ser Leu Leu Leu Leu Leu Glu Pro Gln Ile Ser Gln Gly 
            20                  25                  30          


Leu Val Val Thr Pro Pro Gly Pro Glu Leu Val Leu Asn Val Ser Ser 
        35                  40                  45              


Thr Phe Val Leu Thr Cys Ser Gly Ser Ala Pro Val Val Trp Glu Arg 
    50                  55                  60                  


Met Ser Gln Glu Pro Pro Gln Glu Met Ala Lys Ala Gln Asp Gly Thr 
65                  70                  75                  80  


Phe Ser Ser Val Leu Thr Leu Thr Asn Leu Thr Gly Leu Asp Thr Gly 
                85                  90                  95      


Glu Tyr Phe Cys Thr His Asn Asp Ser Arg Gly Leu Glu Thr Asp Glu 
            100                 105                 110         


Arg Lys Arg Leu Tyr Ile Phe Val Pro Asp Pro Thr Val Gly Phe Leu 
        115                 120                 125             


Pro Asn Asp Ala Glu Glu Leu Phe Ile Phe Leu Thr Glu Ile Thr Glu 
    130                 135                 140                 


Ile Thr Ile Pro Cys Arg Val Thr Asp Pro Gln Leu Val Val Thr Leu 
145                 150                 155                 160 


His Glu Lys Lys Gly Asp Val Ala Leu Pro Val Pro Tyr Asp His Gln 
                165                 170                 175     


Arg Gly Phe Ser Gly Ile Phe Glu Asp Arg Ser Tyr Ile Cys Lys Thr 
            180                 185                 190         


Thr Ile Gly Asp Arg Glu Val Asp Ser Asp Ala Tyr Tyr Val Tyr Arg 
        195                 200                 205             


Leu Gln Val Ser Ser Ile Asn Val Ser Val Asn Ala Val Gln Thr Val 
    210                 215                 220                 


Val Arg Gln Gly Glu Asn Ile Thr Leu Met Cys Ile Val Ile Gly Asn 
225                 230                 235                 240 


Glu Val Val Asn Phe Glu Trp Thr Tyr Pro Arg Lys Glu Ser Gly Arg 
                245                 250                 255     


Leu Val Glu Pro Val Thr Asp Phe Leu Leu Asp Met Pro Tyr His Ile 
            260                 265                 270         


Arg Ser Ile Leu His Ile Pro Ser Ala Glu Leu Glu Asp Ser Gly Thr 
        275                 280                 285             


Tyr Thr Cys Asn Val Thr Glu Ser Val Asn Asp His Gln Asp Glu Lys 
    290                 295                 300                 


Ala Ile Asn Ile Thr Val Val Glu Ser Gly Tyr Val Arg Leu Leu Gly 
305                 310                 315                 320 


Glu Val Gly Thr Leu Gln Phe Ala Glu Leu His Arg Ser Arg Thr Leu 
                325                 330                 335     


Gln Val Val Phe Glu Ala Tyr Pro Pro Pro Thr Val Leu Trp Phe Lys 
            340                 345                 350         


Asp Asn Arg Thr Leu Gly Asp Ser Ser Ala Gly Glu Ile Ala Leu Ser 
        355                 360                 365             


Thr Arg Asn Val Ser Glu Thr Arg Tyr Val Ser Glu Leu Thr Leu Val 
    370                 375                 380                 


Arg Val Lys Val Ala Glu Ala Gly His Tyr Thr Met Arg Ala Phe His 
385                 390                 395                 400 


Glu Asp Ala Glu Val Gln Leu Ser Phe Gln Leu Gln Ile Asn Val Pro 
                405                 410                 415     


Val Arg Val Leu Glu Leu Ser Glu Ser His Pro Asp Ser Gly Glu Gln 
            420                 425                 430         


Thr Val Arg Cys Arg Gly Arg Gly Met Pro Gln Pro Asn Ile Ile Trp 
        435                 440                 445             


Ser Ala Cys Arg Asp Leu Lys Arg Cys Pro Arg Glu Leu Pro Pro Thr 
    450                 455                 460                 


Leu Leu Gly Asn Ser Ser Glu Glu Glu Ser Gln Leu Glu Thr Asn Val 
465                 470                 475                 480 


Thr Tyr Trp Glu Glu Glu Gln Glu Phe Glu Val Val Ser Thr Leu Arg 
                485                 490                 495     


Leu Gln His Val Asp Arg Pro Leu Ser Val Arg Cys Thr Leu Arg Asn 
            500                 505                 510         


Ala Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser Leu 
        515                 520                 525             


Pro Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu 
    530                 535                 540                 


Thr Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys Pro 
545                 550                 555                 560 


Arg Tyr Glu Ile Arg Trp Lys Val Ile Glu Ser Val Ser Ser Asp Gly 
                565                 570                 575     


His Glu Tyr Ile Tyr Val Asp Pro Met Gln Leu Pro Tyr Asp Ser Thr 
            580                 585                 590         


Trp Glu Leu Pro Arg Asp Gln Leu Val Leu Gly Arg Thr Leu Gly Ser 
        595                 600                 605             


Gly Ala Phe Gly Gln Val Val Glu Ala Thr Ala His Gly Leu Ser His 
    610                 615                 620                 


Ser Gln Ala Thr Met Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala 
625                 630                 635                 640 


Arg Ser Ser Glu Lys Gln Ala Leu Met Ser Glu Leu Lys Ile Met Ser 
                645                 650                 655     


His Leu Gly Pro His Leu Asn Val Val Asn Leu Leu Gly Ala Cys Thr 
            660                 665                 670         


Lys Gly Gly Pro Ile Tyr Ile Ile Thr Glu Tyr Cys Arg Tyr Gly Asp 
        675                 680                 685             


Leu Val Asp Tyr Leu His Arg Asn Lys His Thr Phe Leu Gln His His 
    690                 695                 700                 


Ser Asp Lys Arg Arg Pro Pro Ser Ala Glu Leu Tyr Ser Asn Ala Leu 
705                 710                 715                 720 


Pro Val Gly Leu Pro Leu Pro Ser His Val Ser Leu Thr Gly Glu Ser 
                725                 730                 735     


Asp Gly Gly Tyr Met Asp Met Ser Lys Asp Glu Ser Val Asp Tyr Val 
            740                 745                 750         


Pro Met Leu Asp Met Lys Gly Asp Val Lys Tyr Ala Asp Ile Glu Ser 
        755                 760                 765             


Ser Asn Tyr Met Ala Pro Tyr Asp Asn Tyr Val Pro Ser Ala Pro Glu 
    770                 775                 780                 


Arg Thr Cys Arg Ala Thr Leu Ile Asn Glu Ser Pro Val Leu Ser Tyr 
785                 790                 795                 800 


Met Asp Leu Val Gly Phe Ser Tyr Gln Val Ala Asn Gly Met Glu Phe 
                805                 810                 815     


Leu Ala Ser Lys Asn Cys Val His Arg Asp Leu Ala Ala Arg Asn Val 
            820                 825                 830         


Leu Ile Cys Glu Gly Lys Leu Val Lys Ile Cys Asp Phe Gly Leu Ala 
        835                 840                 845             


Arg Asp Ile Met Arg Asp Ser Asn Tyr Ile Ser Lys Gly Ser Thr Phe 
    850                 855                 860                 


Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Ser Leu Tyr 
865                 870                 875                 880 


Thr Thr Leu Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile 
                885                 890                 895     


Phe Thr Leu Gly Gly Thr Pro Tyr Pro Glu Leu Pro Met Asn Glu Gln 
            900                 905                 910         


Phe Tyr Asn Ala Ile Lys Arg Gly Tyr Arg Met Ala Gln Pro Ala His 
        915                 920                 925             


Ala Ser Asp Glu Ile Tyr Glu Ile Met Gln Lys Cys Trp Glu Glu Lys 
    930                 935                 940                 


Phe Glu Ile Arg Pro Pro Phe Ser Gln Leu Val Leu Leu Leu Glu Arg 
945                 950                 955                 960 


Leu Leu Gly Glu Gly Tyr Lys Lys Lys Tyr Gln Gln Val Asp Glu Glu 
                965                 970                 975     


Phe Leu Arg Ser Asp His Pro Ala Ile Leu Arg Ser Gln Ala Arg Leu 
            980                 985                 990         


Pro Gly Phe His Gly Leu Arg Ser  Pro Leu Asp Thr Ser  Ser Val Leu 
        995                 1000                 1005             


Tyr Thr  Ala Val Gln Pro Asn  Glu Gly Asp Asn Asp  Tyr Ile Ile 
    1010                 1015                 1020             


Pro Leu  Pro Asp Pro Lys Pro  Glu Val Ala Asp Glu  Gly Pro Leu 
    1025                 1030                 1035             


Glu Gly  Ser Pro Ser Leu Ala  Ser Ser Thr Leu Asn  Glu Val Asn 
    1040                 1045                 1050             


Thr Ser  Ser Thr Ile Ser Cys  Asp Ser Pro Leu Glu  Pro Gln Asp 
    1055                 1060                 1065             


Glu Pro  Glu Pro Glu Pro Gln  Leu Glu Leu Gln Val  Glu Pro Glu 
    1070                 1075                 1080             


Pro Glu  Leu Glu Gln Leu Pro  Asp Ser Gly Cys Pro  Ala Pro Arg 
    1085                 1090                 1095             


Ala Glu  Ala Glu Asp Ser Phe  Leu 
    1100                 1105     


<210>  10199
<211>  146
<212>  PRT
<213>  Homo Sapiens

<400>  10199

Met Ser Gln Glu Pro Pro Gln Glu Met Ala Lys Ala Gln Asp Gly Thr 
1               5                   10                  15      


Phe Ser Ser Val Leu Thr Leu Thr Asn Leu Thr Gly Leu Asp Thr Gly 
            20                  25                  30          


Glu Tyr Phe Cys Thr His Asn Asp Ser Arg Gly Leu Glu Thr Asp Glu 
        35                  40                  45              


Arg Lys Arg Leu Tyr Ile Phe Val Pro Asp Pro Thr Val Gly Phe Leu 
    50                  55                  60                  


Pro Asn Asp Ala Glu Glu Leu Phe Ile Phe Leu Thr Glu Ile Thr Glu 
65                  70                  75                  80  


Ile Thr Ile Pro Cys Arg Val Thr Asp Pro Gln Leu Val Val Thr Leu 
                85                  90                  95      


His Glu Lys Lys Gly Asp Val Ala Leu Pro Val Pro Tyr Asp His Gln 
            100                 105                 110         


Arg Gly Phe Ser Gly Ile Phe Glu Asp Arg Ser Tyr Ile Cys Lys Thr 
        115                 120                 125             


Thr Ile Gly Asp Arg Glu Val Asp Ser Asp Ala Tyr Tyr Val Tyr Arg 
    130                 135                 140                 


Leu Gln 
145     


<210>  10200
<211>  375
<212>  PRT
<213>  Homo Sapiens

<400>  10200

Met Lys Val Trp Leu Leu Leu Gly Leu Leu Leu Val His Glu Ala Leu 
1               5                   10                  15      


Glu Asp Val Thr Gly Gln His Leu Pro Lys Asn Lys Arg Pro Lys Glu 
            20                  25                  30          


Pro Gly Glu Asn Arg Ile Lys Pro Thr Asn Lys Lys Val Lys Pro Lys 
        35                  40                  45              


Ile Pro Lys Met Lys Asp Arg Asp Ser Ala Asn Ser Ala Pro Lys Thr 
    50                  55                  60                  


Gln Ser Ile Met Met Gln Val Leu Asp Lys Gly Arg Phe Gln Lys Pro 
65                  70                  75                  80  


Ala Ala Thr Leu Ser Leu Leu Ala Gly Gln Thr Val Glu Leu Arg Cys 
                85                  90                  95      


Lys Gly Ser Arg Ile Gly Trp Ser Tyr Pro Ala Tyr Leu Asp Thr Phe 
            100                 105                 110         


Lys Asp Ser Arg Leu Ser Val Lys Gln Asn Glu Arg Tyr Gly Gln Leu 
        115                 120                 125             


Thr Leu Val Asn Ser Thr Ser Ala Asp Thr Gly Glu Phe Ser Cys Trp 
    130                 135                 140                 


Val Gln Leu Cys Ser Gly Tyr Ile Cys Arg Lys Asp Glu Ala Lys Thr 
145                 150                 155                 160 


Gly Ser Thr Tyr Ile Phe Phe Thr Glu Lys Gly Glu Leu Phe Val Pro 
                165                 170                 175     


Ser Pro Ser Tyr Phe Asp Val Val Tyr Leu Asn Pro Asp Arg Gln Ala 
            180                 185                 190         


Val Val Pro Cys Arg Val Thr Val Leu Ser Ala Lys Val Thr Leu His 
        195                 200                 205             


Arg Glu Phe Pro Ala Lys Glu Ile Pro Ala Asn Gly Thr Asp Ile Val 
    210                 215                 220                 


Tyr Asp Met Lys Arg Gly Phe Val Tyr Leu Gln Pro His Ser Glu His 
225                 230                 235                 240 


Gln Gly Val Val Tyr Cys Arg Ala Glu Ala Gly Gly Arg Ser Gln Ile 
                245                 250                 255     


Ser Val Lys Tyr Gln Leu Leu Tyr Val Ala Val Pro Ser Gly Pro Pro 
            260                 265                 270         


Ser Thr Thr Ile Leu Ala Ser Ser Asn Lys Val Lys Ser Gly Asp Asp 
        275                 280                 285             


Ile Ser Val Leu Cys Thr Val Leu Gly Glu Pro Asp Val Glu Val Glu 
    290                 295                 300                 


Phe Thr Trp Ile Phe Pro Gly Gln Lys Asp Glu Arg Pro Val Thr Ile 
305                 310                 315                 320 


Gln Asp Thr Trp Arg Leu Ile His Arg Gly Leu Gly His Thr Thr Arg 
                325                 330                 335     


Ile Ser Gln Ser Val Ile Thr Val Glu Asp Phe Glu Thr Ile Asp Ala 
            340                 345                 350         


Gly Tyr Tyr Ile Cys Thr Ala Gln Asn Leu Gln Gly Gln Thr Thr Val 
        355                 360                 365             


Ala Thr Thr Val Glu Phe Ser 
    370                 375 


<210>  10201
<211>  375
<212>  PRT
<213>  Homo Sapiens

<400>  10201

Met Lys Val Trp Leu Leu Leu Gly Leu Leu Leu Val His Glu Ala Leu 
1               5                   10                  15      


Glu Asp Val Thr Gly Gln His Leu Pro Lys Asn Lys Arg Pro Lys Glu 
            20                  25                  30          


Pro Gly Glu Asn Arg Ile Lys Pro Thr Asn Lys Lys Val Lys Pro Lys 
        35                  40                  45              


Ile Pro Lys Met Lys Asp Arg Asp Ser Ala Asn Ser Ala Pro Lys Thr 
    50                  55                  60                  


Gln Ser Ile Met Met Gln Val Leu Asp Lys Gly Arg Phe Gln Lys Pro 
65                  70                  75                  80  


Ala Ala Thr Leu Ser Leu Leu Ala Gly Gln Thr Val Glu Leu Arg Cys 
                85                  90                  95      


Lys Gly Ser Arg Ile Gly Trp Ser Tyr Pro Ala Tyr Leu Asp Thr Phe 
            100                 105                 110         


Lys Asp Ser Arg Leu Ser Val Lys Gln Asn Glu Arg Tyr Gly Gln Leu 
        115                 120                 125             


Thr Leu Val Asn Ser Thr Ser Ala Asp Thr Gly Glu Phe Ser Cys Trp 
    130                 135                 140                 


Val Gln Leu Cys Ser Gly Tyr Ile Cys Arg Lys Asp Glu Ala Lys Thr 
145                 150                 155                 160 


Gly Ser Thr Tyr Ile Phe Phe Thr Glu Lys Gly Glu Leu Phe Val Pro 
                165                 170                 175     


Ser Pro Ser Tyr Phe Asp Val Val Tyr Leu Asn Pro Asp Arg Gln Ala 
            180                 185                 190         


Val Val Pro Cys Arg Val Thr Val Leu Ser Ala Lys Val Thr Leu His 
        195                 200                 205             


Arg Glu Phe Pro Ala Lys Glu Ile Pro Ala Asn Gly Thr Asp Ile Val 
    210                 215                 220                 


Tyr Asp Met Lys Arg Gly Phe Val Tyr Leu Gln Pro His Ser Glu His 
225                 230                 235                 240 


Gln Gly Val Val Tyr Cys Arg Ala Glu Ala Gly Gly Arg Ser Gln Ile 
                245                 250                 255     


Ser Val Lys Tyr Gln Leu Leu Tyr Val Ala Val Pro Ser Gly Pro Pro 
            260                 265                 270         


Ser Thr Thr Ile Leu Ala Ser Ser Asn Lys Val Lys Ser Gly Asp Asp 
        275                 280                 285             


Ile Ser Val Leu Cys Thr Val Leu Gly Glu Pro Asp Val Glu Val Glu 
    290                 295                 300                 


Phe Thr Trp Ile Phe Pro Gly Gln Lys Asp Glu Arg Pro Val Thr Ile 
305                 310                 315                 320 


Gln Asp Thr Trp Arg Leu Ile His Arg Gly Leu Gly His Thr Thr Arg 
                325                 330                 335     


Ile Ser Gln Ser Val Ile Thr Val Glu Asp Phe Glu Thr Ile Asp Ala 
            340                 345                 350         


Gly Tyr Tyr Ile Cys Thr Ala Gln Asn Leu Gln Gly Gln Thr Thr Val 
        355                 360                 365             


Ala Thr Thr Val Glu Phe Ser 
    370                 375 


<210>  10202
<211>  109
<212>  PRT
<213>  Homo Sapiens

<400>  10202

Met Glu Leu Gln Thr Tyr Arg Tyr His Gly His Ser Met Ser Asp Pro 
1               5                   10                  15      


Gly Val Ser Tyr Arg Thr Arg Glu Glu Ile Gln Glu Val Arg Ser Lys 
            20                  25                  30          


Ser Asp Pro Ile Met Leu Leu Lys Asp Arg Met Val Asn Ser Asn Leu 
        35                  40                  45              


Ala Ser Val Glu Glu Leu Lys Glu Ile Asp Val Glu Val Arg Lys Glu 
    50                  55                  60                  


Ile Glu Asp Ala Ala Gln Phe Ala Thr Ala Asp Pro Glu Pro Pro Leu 
65                  70                  75                  80  


Glu Glu Leu Gly Tyr His Ile Tyr Ser Ser Asp Pro Pro Phe Glu Val 
                85                  90                  95      


Arg Gly Ala Asn Gln Trp Ile Lys Phe Lys Ser Val Ser 
            100                 105                 


<210>  10203
<211>  359
<212>  PRT
<213>  Homo Sapiens

<400>  10203

Met Arg Lys Met Leu Ala Ala Val Ser Arg Val Leu Ser Gly Ala Ser 
1               5                   10                  15      


Gln Lys Pro Ala Ser Arg Val Leu Val Ala Ser Arg Asn Phe Ala Asn 
            20                  25                  30          


Asp Ala Thr Phe Glu Ile Lys Lys Cys Asp Leu His Arg Leu Glu Glu 
        35                  40                  45              


Gly Pro Pro Val Thr Thr Val Leu Thr Arg Glu Asp Gly Leu Lys Tyr 
    50                  55                  60                  


Tyr Arg Met Met Gln Thr Val Arg Arg Met Glu Leu Lys Ala Asp Gln 
65                  70                  75                  80  


Leu Tyr Lys Gln Lys Ile Ile Arg Gly Phe Cys His Leu Cys Asp Gly 
                85                  90                  95      


Gln Glu Ala Cys Cys Val Gly Leu Glu Ala Gly Ile Asn Pro Thr Asp 
            100                 105                 110         


His Leu Ile Thr Ala Tyr Arg Ala His Gly Phe Thr Phe Thr Arg Gly 
        115                 120                 125             


Leu Ser Val Arg Glu Ile Leu Ala Glu Leu Thr Gly Arg Lys Gly Gly 
    130                 135                 140                 


Cys Ala Lys Gly Lys Gly Gly Ser Met His Met Tyr Ala Lys Asn Phe 
145                 150                 155                 160 


Tyr Gly Gly Asn Gly Ile Val Gly Ala Gln Gly Gln Ile Phe Glu Ala 
                165                 170                 175     


Tyr Asn Met Ala Ala Leu Trp Lys Leu Pro Cys Ile Phe Ile Cys Glu 
            180                 185                 190         


Asn Asn Arg Tyr Gly Met Gly Thr Ser Val Glu Arg Ala Ala Ala Ser 
        195                 200                 205             


Thr Asp Tyr Tyr Lys Arg Gly Asp Phe Ile Pro Gly Leu Arg Val Asp 
    210                 215                 220                 


Gly Met Asp Ile Leu Cys Val Arg Glu Ala Thr Arg Phe Ala Ala Ala 
225                 230                 235                 240 


Tyr Cys Arg Ser Gly Lys Gly Pro Ile Leu Met Glu Leu Gln Thr Tyr 
                245                 250                 255     


Arg Tyr His Gly His Ser Met Ser Asp Pro Gly Val Ser Tyr Arg Thr 
            260                 265                 270         


Arg Glu Glu Ile Gln Glu Val Arg Ser Lys Ser Asp Pro Ile Met Leu 
        275                 280                 285             


Leu Lys Asp Arg Met Val Asn Ser Asn Leu Ala Ser Val Glu Glu Leu 
    290                 295                 300                 


Lys Glu Ile Asp Val Glu Val Arg Lys Glu Ile Glu Asp Ala Ala Gln 
305                 310                 315                 320 


Phe Ala Thr Ala Asp Pro Glu Pro Pro Leu Glu Glu Leu Gly Tyr His 
                325                 330                 335     


Ile Tyr Ser Ser Asp Pro Pro Phe Glu Val Arg Gly Ala Asn Gln Trp 
            340                 345                 350         


Ile Lys Phe Lys Ser Val Ser 
        355                 


<210>  10204
<211>  390
<212>  PRT
<213>  Homo Sapiens

<400>  10204

Met Arg Lys Met Leu Ala Ala Val Ser Arg Val Leu Ser Gly Ala Ser 
1               5                   10                  15      


Gln Lys Pro Ala Ser Arg Val Leu Val Ala Ser Arg Asn Phe Ala Asn 
            20                  25                  30          


Asp Ala Thr Phe Glu Ile Lys Lys Cys Asp Leu His Arg Leu Glu Glu 
        35                  40                  45              


Gly Pro Pro Val Thr Thr Val Leu Thr Arg Glu Asp Gly Leu Lys Tyr 
    50                  55                  60                  


Tyr Arg Met Met Gln Thr Val Arg Arg Met Glu Leu Lys Ala Asp Gln 
65                  70                  75                  80  


Leu Tyr Lys Gln Lys Ile Ile Arg Gly Phe Cys His Leu Cys Asp Gly 
                85                  90                  95      


Gln Glu Ala Cys Cys Val Gly Leu Glu Ala Gly Ile Asn Pro Thr Asp 
            100                 105                 110         


His Leu Ile Thr Ala Tyr Arg Ala His Gly Phe Thr Phe Thr Arg Gly 
        115                 120                 125             


Leu Ser Val Arg Glu Ile Leu Ala Glu Leu Thr Gly Arg Lys Gly Gly 
    130                 135                 140                 


Cys Ala Lys Gly Lys Gly Gly Ser Met His Met Tyr Ala Lys Asn Phe 
145                 150                 155                 160 


Tyr Gly Gly Asn Gly Ile Val Gly Ala Gln Val Pro Leu Gly Ala Gly 
                165                 170                 175     


Ile Ala Leu Ala Cys Lys Tyr Asn Gly Lys Asp Glu Val Cys Leu Thr 
            180                 185                 190         


Leu Tyr Gly Asp Gly Ala Ala Asn Gln Gly Gln Ile Phe Glu Ala Tyr 
        195                 200                 205             


Asn Met Ala Ala Leu Trp Lys Leu Pro Cys Ile Phe Ile Cys Glu Asn 
    210                 215                 220                 


Asn Arg Tyr Gly Met Gly Thr Ser Val Glu Arg Ala Ala Ala Ser Thr 
225                 230                 235                 240 


Asp Tyr Tyr Lys Arg Gly Asp Phe Ile Pro Gly Leu Arg Val Asp Gly 
                245                 250                 255     


Met Asp Ile Leu Cys Val Arg Glu Ala Thr Arg Phe Ala Ala Ala Tyr 
            260                 265                 270         


Cys Arg Ser Gly Lys Gly Pro Ile Leu Met Glu Leu Gln Thr Tyr Arg 
        275                 280                 285             


Tyr His Gly His Ser Met Ser Asp Pro Gly Val Ser Tyr Arg Thr Arg 
    290                 295                 300                 


Glu Glu Ile Gln Glu Val Arg Ser Lys Ser Asp Pro Ile Met Leu Leu 
305                 310                 315                 320 


Lys Asp Arg Met Val Asn Ser Asn Leu Ala Ser Val Glu Glu Leu Lys 
                325                 330                 335     


Glu Ile Asp Val Glu Val Arg Lys Glu Ile Glu Asp Ala Ala Gln Phe 
            340                 345                 350         


Ala Thr Ala Asp Pro Glu Pro Pro Leu Glu Glu Leu Gly Tyr His Ile 
        355                 360                 365             


Tyr Ser Ser Asp Pro Pro Phe Glu Val Arg Gly Ala Asn Gln Trp Ile 
    370                 375                 380                 


Lys Phe Lys Ser Val Ser 
385                 390 


<210>  10205
<211>  180
<212>  PRT
<213>  Homo Sapiens

<400>  10205

Met Arg Lys Met Leu Ala Ala Val Ser Arg Val Leu Ser Gly Ala Ser 
1               5                   10                  15      


Gln Lys Pro Ala Ser Arg Val Leu Val Ala Ser Arg Asn Phe Ala Asn 
            20                  25                  30          


Asp Ala Thr Phe Glu Ile Lys Lys Cys Asp Leu His Arg Leu Glu Glu 
        35                  40                  45              


Gly Pro Pro Val Thr Thr Val Leu Thr Arg Glu Asp Gly Leu Lys Tyr 
    50                  55                  60                  


Tyr Arg Met Met Gln Thr Val Arg Arg Met Glu Leu Lys Ala Asp Gln 
65                  70                  75                  80  


Leu Tyr Lys Gln Lys Ile Ile Arg Gly Phe Cys His Leu Cys Asp Gly 
                85                  90                  95      


Gln Glu Ala Cys Cys Val Gly Leu Glu Ala Gly Ile Asn Pro Thr Asp 
            100                 105                 110         


His Leu Ile Thr Ala Tyr Arg Ala His Gly Phe Thr Phe Thr Arg Gly 
        115                 120                 125             


Leu Ser Val Arg Glu Ile Leu Ala Glu Leu Thr Gly Arg Lys Gly Gly 
    130                 135                 140                 


Cys Ala Lys Gly Lys Gly Gly Ser Met His Met Tyr Ala Lys Asn Phe 
145                 150                 155                 160 


Tyr Gly Gly Asn Gly Ile Val Gly Ala Gln Val Val Lys Asp Glu Asp 
                165                 170                 175     


Cys Val Leu Leu 
            180 


<210>  10206
<211>  204
<212>  PRT
<213>  Homo Sapiens

<400>  10206

Met Arg Lys Met Leu Ala Ala Val Ser Arg Val Leu Ser Gly Ala Ser 
1               5                   10                  15      


Gln Lys Pro Ala Ser Arg Val Leu Val Ala Ser Arg Asn Phe Ala Asn 
            20                  25                  30          


Asp Ala Thr Phe Glu Ile Lys Lys Cys Asp Leu His Arg Leu Glu Glu 
        35                  40                  45              


Gly Pro Pro Val Thr Thr Val Leu Thr Arg Glu Asp Gly Leu Lys Tyr 
    50                  55                  60                  


Tyr Arg Met Met Gln Thr Val Arg Arg Met Glu Leu Lys Ala Asp Gln 
65                  70                  75                  80  


Leu Tyr Lys Gln Lys Ile Ile Arg Gly Phe Cys His Leu Cys Asp Gly 
                85                  90                  95      


Gln Phe Leu Leu Pro Leu Thr Gln Glu Ala Cys Cys Val Gly Leu Glu 
            100                 105                 110         


Ala Gly Ile Asn Pro Thr Asp His Leu Ile Thr Ala Tyr Arg Ala His 
        115                 120                 125             


Gly Phe Thr Phe Thr Arg Gly Leu Ser Val Arg Glu Ile Leu Ala Glu 
    130                 135                 140                 


Leu Thr Gly Arg Lys Gly Gly Cys Ala Lys Gly Lys Gly Gly Ser Met 
145                 150                 155                 160 


His Met Tyr Ala Lys Asn Phe Tyr Gly Gly Asn Gly Ile Val Gly Ala 
                165                 170                 175     


Gln Val Pro Leu Gly Ala Gly Ile Ala Leu Ala Cys Lys Tyr Asn Gly 
            180                 185                 190         


Lys Asp Glu Val Cys Leu Thr Leu Tyr Gly Asp Gly 
        195                 200                 


<210>  10207
<211>  397
<212>  PRT
<213>  Homo Sapiens

<400>  10207

Met Arg Lys Met Leu Ala Ala Val Ser Arg Val Leu Ser Gly Ala Ser 
1               5                   10                  15      


Gln Lys Pro Ala Ser Arg Val Leu Val Ala Ser Arg Asn Phe Ala Asn 
            20                  25                  30          


Asp Ala Thr Phe Glu Ile Lys Lys Cys Asp Leu His Arg Leu Glu Glu 
        35                  40                  45              


Gly Pro Pro Val Thr Thr Val Leu Thr Arg Glu Asp Gly Leu Lys Tyr 
    50                  55                  60                  


Tyr Arg Met Met Gln Thr Val Arg Arg Met Glu Leu Lys Ala Asp Gln 
65                  70                  75                  80  


Leu Tyr Lys Gln Lys Ile Ile Arg Gly Phe Cys His Leu Cys Asp Gly 
                85                  90                  95      


Gln Phe Leu Leu Pro Leu Thr Gln Glu Ala Cys Cys Val Gly Leu Glu 
            100                 105                 110         


Ala Gly Ile Asn Pro Thr Asp His Leu Ile Thr Ala Tyr Arg Ala His 
        115                 120                 125             


Gly Phe Thr Phe Thr Arg Gly Leu Ser Val Arg Glu Ile Leu Ala Glu 
    130                 135                 140                 


Leu Thr Gly Arg Lys Gly Gly Cys Ala Lys Gly Lys Gly Gly Ser Met 
145                 150                 155                 160 


His Met Tyr Ala Lys Asn Phe Tyr Gly Gly Asn Gly Ile Val Gly Ala 
                165                 170                 175     


Gln Val Pro Leu Gly Ala Gly Ile Ala Leu Ala Cys Lys Tyr Asn Gly 
            180                 185                 190         


Lys Asp Glu Val Cys Leu Thr Leu Tyr Gly Asp Gly Ala Ala Asn Gln 
        195                 200                 205             


Gly Gln Ile Phe Glu Ala Tyr Asn Met Ala Ala Leu Trp Lys Leu Pro 
    210                 215                 220                 


Cys Ile Phe Ile Cys Glu Asn Asn Arg Tyr Gly Met Gly Thr Ser Val 
225                 230                 235                 240 


Glu Arg Ala Ala Ala Ser Thr Asp Tyr Tyr Lys Arg Gly Asp Phe Ile 
                245                 250                 255     


Pro Gly Leu Arg Val Asp Gly Met Asp Ile Leu Cys Val Arg Glu Ala 
            260                 265                 270         


Thr Arg Phe Ala Ala Ala Tyr Cys Arg Ser Gly Lys Gly Pro Ile Leu 
        275                 280                 285             


Met Glu Leu Gln Thr Tyr Arg Tyr His Gly His Ser Met Ser Asp Pro 
    290                 295                 300                 


Gly Val Ser Tyr Arg Thr Arg Glu Glu Ile Gln Glu Val Arg Ser Lys 
305                 310                 315                 320 


Ser Asp Pro Ile Met Leu Leu Lys Asp Arg Met Val Asn Ser Asn Leu 
                325                 330                 335     


Ala Ser Val Glu Glu Leu Lys Glu Ile Asp Val Glu Val Arg Lys Glu 
            340                 345                 350         


Ile Glu Asp Ala Ala Gln Phe Ala Thr Ala Asp Pro Glu Pro Pro Leu 
        355                 360                 365             


Glu Glu Leu Gly Tyr His Ile Tyr Ser Ser Asp Pro Pro Phe Glu Val 
    370                 375                 380                 


Arg Gly Ala Asn Gln Trp Ile Lys Phe Lys Ser Val Ser 
385                 390                 395         


<210>  10208
<211>  121
<212>  PRT
<213>  Homo Sapiens

<400>  10208

Met Arg Lys Met Leu Ala Ala Val Ser Arg Val Leu Ser Gly Ala Ser 
1               5                   10                  15      


Gln Lys Pro Phe Ala Gly Ser Pro Pro Pro Arg His Leu Thr Val Gly 
            20                  25                  30          


Arg Lys Leu Ser Ser Arg Tyr Glu Val Thr Phe Glu Ser Ala Gln Ala 
        35                  40                  45              


Ser Arg Val Leu Val Ala Ser Arg Asn Phe Ala Asn Asp Ala Thr Phe 
    50                  55                  60                  


Glu Ile Lys Lys Cys Asp Leu His Arg Leu Glu Glu Gly Pro Pro Val 
65                  70                  75                  80  


Thr Thr Val Leu Thr Arg Glu Asp Gly Leu Lys Tyr Tyr Arg Met Met 
                85                  90                  95      


Gln Thr Val Arg Arg Met Glu Leu Lys Ala Asp Gln Leu Tyr Lys Gln 
            100                 105                 110         


Lys Ile Ile Arg Gly Phe Cys His Leu 
        115                 120     


<210>  10209
<211>  205
<212>  PRT
<213>  Homo Sapiens

<400>  10209

Met Arg Lys Met Leu Ala Ala Val Ser Arg Val Leu Ser Gly Ala Ser 
1               5                   10                  15      


Gln Lys Pro Arg His Gly Leu Ala Thr Leu Pro Ser Leu Val Ser Ile 
            20                  25                  30          


Ser Arg Leu Lys Gln Ser Ser His Leu Gly Leu Pro Lys Cys Trp Asp 
        35                  40                  45              


Tyr Ser His Ser Leu Lys Thr Arg Gln Ala Ser Arg Val Leu Val Ala 
    50                  55                  60                  


Ser Arg Asn Phe Ala Asn Asp Ala Thr Phe Glu Ile Lys Lys Cys Asp 
65                  70                  75                  80  


Leu His Arg Leu Glu Glu Gly Pro Pro Val Thr Thr Val Leu Thr Arg 
                85                  90                  95      


Glu Asp Gly Leu Lys Tyr Tyr Arg Met Met Gln Thr Val Arg Arg Met 
            100                 105                 110         


Glu Leu Lys Ala Asp Gln Leu Tyr Lys Gln Lys Ile Ile Arg Gly Phe 
        115                 120                 125             


Cys His Leu Cys Asp Gly Gln Glu Ala Cys Cys Val Gly Leu Glu Ala 
    130                 135                 140                 


Gly Ile Asn Pro Thr Asp His Leu Ile Thr Ala Tyr Arg Ala His Gly 
145                 150                 155                 160 


Phe Thr Phe Thr Arg Gly Leu Ser Val Arg Glu Ile Leu Ala Glu Leu 
                165                 170                 175     


Thr Gly Arg Lys Gly Gly Cys Ala Lys Gly Lys Gly Gly Ser Met His 
            180                 185                 190         


Met Tyr Ala Lys Asn Phe Tyr Gly Gly Asn Gly Ile Val 
        195                 200                 205 


<210>  10210
<211>  428
<212>  PRT
<213>  Homo Sapiens

<400>  10210

Met Arg Lys Met Leu Ala Ala Val Ser Arg Val Leu Ser Gly Ala Ser 
1               5                   10                  15      


Gln Lys Pro Arg His Gly Leu Ala Thr Leu Pro Ser Leu Val Ser Ile 
            20                  25                  30          


Ser Arg Leu Lys Gln Ser Ser His Leu Gly Leu Pro Lys Cys Trp Asp 
        35                  40                  45              


Tyr Ser His Ser Leu Lys Thr Arg Gln Ala Ser Arg Val Leu Val Ala 
    50                  55                  60                  


Ser Arg Asn Phe Ala Asn Asp Ala Thr Phe Glu Ile Lys Lys Cys Asp 
65                  70                  75                  80  


Leu His Arg Leu Glu Glu Gly Pro Pro Val Thr Thr Val Leu Thr Arg 
                85                  90                  95      


Glu Asp Gly Leu Lys Tyr Tyr Arg Met Met Gln Thr Val Arg Arg Met 
            100                 105                 110         


Glu Leu Lys Ala Asp Gln Leu Tyr Lys Gln Lys Ile Ile Arg Gly Phe 
        115                 120                 125             


Cys His Leu Cys Asp Gly Gln Glu Ala Cys Cys Val Gly Leu Glu Ala 
    130                 135                 140                 


Gly Ile Asn Pro Thr Asp His Leu Ile Thr Ala Tyr Arg Ala His Gly 
145                 150                 155                 160 


Phe Thr Phe Thr Arg Gly Leu Ser Val Arg Glu Ile Leu Ala Glu Leu 
                165                 170                 175     


Thr Gly Arg Lys Gly Gly Cys Ala Lys Gly Lys Gly Gly Ser Met His 
            180                 185                 190         


Met Tyr Ala Lys Asn Phe Tyr Gly Gly Asn Gly Ile Val Gly Ala Gln 
        195                 200                 205             


Val Pro Leu Gly Ala Gly Ile Ala Leu Ala Cys Lys Tyr Asn Gly Lys 
    210                 215                 220                 


Asp Glu Val Cys Leu Thr Leu Tyr Gly Asp Gly Ala Ala Asn Gln Gly 
225                 230                 235                 240 


Gln Ile Phe Glu Ala Tyr Asn Met Ala Ala Leu Trp Lys Leu Pro Cys 
                245                 250                 255     


Ile Phe Ile Cys Glu Asn Asn Arg Tyr Gly Met Gly Thr Ser Val Glu 
            260                 265                 270         


Arg Ala Ala Ala Ser Thr Asp Tyr Tyr Lys Arg Gly Asp Phe Ile Pro 
        275                 280                 285             


Gly Leu Arg Val Asp Gly Met Asp Ile Leu Cys Val Arg Glu Ala Thr 
    290                 295                 300                 


Arg Phe Ala Ala Ala Tyr Cys Arg Ser Gly Lys Gly Pro Ile Leu Met 
305                 310                 315                 320 


Glu Leu Gln Thr Tyr Arg Tyr His Gly His Ser Met Ser Asp Pro Gly 
                325                 330                 335     


Val Ser Tyr Arg Thr Arg Glu Glu Ile Gln Glu Val Arg Ser Lys Ser 
            340                 345                 350         


Asp Pro Ile Met Leu Leu Lys Asp Arg Met Val Asn Ser Asn Leu Ala 
        355                 360                 365             


Ser Val Glu Glu Leu Lys Glu Ile Asp Val Glu Val Arg Lys Glu Ile 
    370                 375                 380                 


Glu Asp Ala Ala Gln Phe Ala Thr Ala Asp Pro Glu Pro Pro Leu Glu 
385                 390                 395                 400 


Glu Leu Gly Tyr His Ile Tyr Ser Ser Asp Pro Pro Phe Glu Val Arg 
                405                 410                 415     


Gly Ala Asn Gln Trp Ile Lys Phe Lys Ser Val Ser 
            420                 425             


<210>  10211
<211>  154
<212>  PRT
<213>  Homo Sapiens

<400>  10211

Ala Val Leu Asn Gly Gln Val Lys Glu Ile Pro Pro Asp Trp Asp Gln 
1               5                   10                  15      


Arg Pro Val Lys Thr Leu Val Gly Lys Asn Phe Glu Gln Val Ala Phe 
            20                  25                  30          


Asp Glu Thr Lys Asn Val Phe Val Lys Phe Tyr Ala Pro Trp Cys Thr 
        35                  40                  45              


His Cys Lys Glu Met Ala Pro Ala Trp Glu Ala Leu Ala Glu Lys Tyr 
    50                  55                  60                  


Gln Asp His Glu Asp Ile Ile Ile Ala Glu Leu Asp Ala Thr Ala Asn 
65                  70                  75                  80  


Glu Leu Asp Ala Phe Ala Val His Gly Phe Pro Thr Leu Lys Tyr Phe 
                85                  90                  95      


Pro Ala Gly Pro Gly Arg Lys Val Ile Glu Tyr Lys Ser Thr Arg Asp 
            100                 105                 110         


Leu Glu Thr Phe Ser Lys Phe Leu Asp Asn Gly Gly Val Leu Pro Thr 
        115                 120                 125             


Glu Glu Pro Pro Glu Glu Pro Ala Ala Pro Phe Pro Glu Pro Pro Ala 
    130                 135                 140                 


Asn Ser Thr Met Gly Ser Lys Glu Glu Leu 
145                 150                 


<210>  10212
<211>  522
<212>  PRT
<213>  Homo Sapiens

<400>  10212

Met Ser Arg Gln Leu Leu Pro Val Leu Leu Leu Leu Leu Leu Arg Ala 
1               5                   10                  15      


Ser Cys Pro Trp Gly Gln Glu Gln Gly Ala Arg Ser Pro Ser Glu Glu 
            20                  25                  30          


Pro Pro Glu Glu Glu Ile Pro Lys Glu Asp Gly Ile Leu Val Leu Ser 
        35                  40                  45              


Arg His Thr Leu Gly Leu Ala Leu Arg Glu His Pro Ala Leu Leu Val 
    50                  55                  60                  


Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Gln Ala Leu Ala Pro Glu 
65                  70                  75                  80  


Tyr Ser Lys Ala Ala Ala Val Leu Ala Ala Glu Ser Met Val Val Thr 
                85                  90                  95      


Leu Ala Lys Val Asp Gly Pro Ala Gln Arg Glu Leu Ala Glu Glu Phe 
            100                 105                 110         


Gly Val Thr Glu Tyr Pro Thr Leu Lys Phe Phe Arg Asn Gly Asn Arg 
        115                 120                 125             


Thr His Pro Glu Glu Tyr Thr Gly Pro Arg Asp Ala Glu Gly Ile Ala 
    130                 135                 140                 


Glu Trp Leu Arg Arg Arg Val Gly Pro Ser Ala Met Arg Leu Glu Asp 
145                 150                 155                 160 


Glu Ala Ala Ala Gln Ala Leu Ile Gly Gly Arg Asp Leu Val Val Ile 
                165                 170                 175     


Gly Phe Phe Gln Asp Glu Asp Val Ala Thr Phe Leu Ala Leu Ala Gln 
            180                 185                 190         


Asp Ala Leu Asp Met Thr Phe Gly Leu Thr Asp Arg Pro Arg Leu Phe 
        195                 200                 205             


Gln Gln Phe Gly Leu Thr Lys Asp Thr Val Val Leu Phe Lys Lys Phe 
    210                 215                 220                 


Asp Glu Gly Arg Ala Asp Phe Pro Val Asp Glu Glu Leu Gly Leu Asp 
225                 230                 235                 240 


Leu Gly Asp Leu Ser Arg Phe Leu Val Thr His Ser Met Arg Leu Val 
                245                 250                 255     


Thr Glu Phe Asn Ser Gln Thr Ser Ala Lys Ile Phe Ala Ala Arg Ile 
            260                 265                 270         


Leu Asn His Leu Leu Leu Phe Val Asn Gln Thr Leu Ala Ala His Arg 
        275                 280                 285             


Glu Leu Leu Ala Gly Phe Gly Glu Ala Ala Pro Arg Phe Arg Gly Gln 
    290                 295                 300                 


Val Leu Phe Val Val Val Asp Val Ala Ala Asp Asn Glu His Val Leu 
305                 310                 315                 320 


Gln Tyr Phe Gly Leu Lys Ala Glu Ala Ala Pro Thr Leu Arg Leu Val 
                325                 330                 335     


Asn Leu Glu Thr Thr Lys Lys Tyr Ala Pro Val Asp Gly Gly Pro Val 
            340                 345                 350         


Thr Ala Ala Ser Ile Thr Ala Phe Cys His Ala Val Leu Asn Gly Gln 
        355                 360                 365             


Val Lys Pro Tyr Leu Leu Ser Gln Glu Ile Pro Pro Asp Trp Asp Gln 
    370                 375                 380                 


Arg Pro Val Lys Thr Leu Val Gly Lys Asn Phe Glu Gln Val Ala Phe 
385                 390                 395                 400 


Asp Glu Thr Lys Asn Val Phe Val Lys Phe Tyr Ala Pro Trp Cys Thr 
                405                 410                 415     


His Cys Lys Glu Met Ala Pro Ala Trp Glu Ala Leu Ala Glu Lys Tyr 
            420                 425                 430         


Gln Asp His Glu Asp Ile Ile Ile Ala Glu Leu Asp Ala Thr Ala Asn 
        435                 440                 445             


Glu Leu Asp Ala Phe Ala Val His Gly Phe Pro Thr Leu Lys Tyr Phe 
    450                 455                 460                 


Pro Ala Gly Pro Gly Arg Lys Val Ile Glu Tyr Lys Ser Thr Arg Asp 
465                 470                 475                 480 


Leu Glu Thr Phe Ser Lys Phe Leu Asp Asn Gly Gly Val Leu Pro Thr 
                485                 490                 495     


Glu Glu Pro Pro Glu Glu Pro Ala Ala Pro Phe Pro Glu Pro Pro Ala 
            500                 505                 510         


Asn Ser Thr Met Gly Ser Lys Glu Glu Leu 
        515                 520         


<210>  10213
<211>  525
<212>  PRT
<213>  Homo Sapiens

<400>  10213

Met Ser Arg Gln Leu Leu Pro Val Leu Leu Leu Leu Leu Leu Arg Ala 
1               5                   10                  15      


Ser Cys Pro Trp Gly Gln Glu Gln Gly Ala Arg Ser Pro Ser Glu Glu 
            20                  25                  30          


Pro Pro Glu Glu Glu Ile Pro Lys Glu Asp Gly Ile Leu Val Leu Ser 
        35                  40                  45              


Arg His Thr Leu Gly Leu Ala Leu Arg Glu His Pro Ala Leu Leu Val 
    50                  55                  60                  


Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Gln Ala Leu Ala Pro Glu 
65                  70                  75                  80  


Tyr Ser Lys Ala Ala Ala Val Leu Ala Ala Glu Ser Met Val Val Thr 
                85                  90                  95      


Leu Ala Lys Val Asp Gly Pro Ala Gln Arg Glu Leu Ala Glu Glu Phe 
            100                 105                 110         


Gly Val Thr Glu Tyr Pro Thr Leu Lys Phe Phe Arg Asn Gly Asn Arg 
        115                 120                 125             


Thr His Pro Glu Glu Tyr Thr Gly Pro Arg Asp Ala Glu Gly Ile Ala 
    130                 135                 140                 


Glu Trp Leu Arg Arg Arg Val Gly Pro Ser Ala Met Arg Leu Glu Asp 
145                 150                 155                 160 


Glu Ala Ala Ala Gln Ala Leu Ile Gly Gly Arg Asp Leu Val Val Ile 
                165                 170                 175     


Gly Phe Phe Gln Asp Leu Gln Asp Glu Asp Val Ala Thr Phe Leu Ala 
            180                 185                 190         


Leu Ala Gln Asp Ala Leu Asp Met Thr Phe Gly Leu Thr Asp Arg Pro 
        195                 200                 205             


Arg Leu Phe Gln Gln Phe Gly Leu Thr Lys Asp Thr Val Val Leu Phe 
    210                 215                 220                 


Lys Lys Phe Asp Glu Gly Arg Ala Asp Phe Pro Val Asp Glu Glu Leu 
225                 230                 235                 240 


Gly Leu Asp Leu Gly Asp Leu Ser Arg Phe Leu Val Thr His Ser Met 
                245                 250                 255     


Arg Leu Val Thr Glu Phe Asn Ser Gln Thr Ser Ala Lys Ile Phe Ala 
            260                 265                 270         


Ala Arg Ile Leu Asn His Leu Leu Leu Phe Val Asn Gln Thr Leu Ala 
        275                 280                 285             


Ala His Arg Glu Leu Leu Ala Gly Phe Gly Glu Ala Ala Pro Arg Phe 
    290                 295                 300                 


Arg Gly Gln Val Leu Phe Val Val Val Asp Val Ala Ala Asp Asn Glu 
305                 310                 315                 320 


His Val Leu Gln Tyr Phe Gly Leu Lys Ala Glu Ala Ala Pro Thr Leu 
                325                 330                 335     


Arg Leu Val Asn Leu Glu Thr Thr Lys Lys Tyr Ala Pro Val Asp Gly 
            340                 345                 350         


Gly Pro Val Thr Ala Ala Ser Ile Thr Ala Phe Cys His Ala Val Leu 
        355                 360                 365             


Asn Gly Gln Val Lys Pro Tyr Leu Leu Ser Gln Glu Ile Pro Pro Asp 
    370                 375                 380                 


Trp Asp Gln Arg Pro Val Lys Thr Leu Val Gly Lys Asn Phe Glu Gln 
385                 390                 395                 400 


Val Ala Phe Asp Glu Thr Lys Asn Val Phe Val Lys Phe Tyr Ala Pro 
                405                 410                 415     


Trp Cys Thr His Cys Lys Glu Met Ala Pro Ala Trp Glu Ala Leu Ala 
            420                 425                 430         


Glu Lys Tyr Gln Asp His Glu Asp Ile Ile Ile Ala Glu Leu Asp Ala 
        435                 440                 445             


Thr Ala Asn Glu Leu Asp Ala Phe Ala Val His Gly Phe Pro Thr Leu 
    450                 455                 460                 


Lys Tyr Phe Pro Ala Gly Pro Gly Arg Lys Val Ile Glu Tyr Lys Ser 
465                 470                 475                 480 


Thr Arg Asp Leu Glu Thr Phe Ser Lys Phe Leu Asp Asn Gly Gly Val 
                485                 490                 495     


Leu Pro Thr Glu Glu Pro Pro Glu Glu Pro Ala Ala Pro Phe Pro Glu 
            500                 505                 510         


Pro Pro Ala Asn Ser Thr Met Gly Ser Lys Glu Glu Leu 
        515                 520                 525 


<210>  10214
<211>  227
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  10214

Xaa Leu Leu Pro Val Leu Leu Leu Leu Leu Leu Arg Ala Ser Cys Pro 
1               5                   10                  15      


Trp Gly Gln Glu Gln Gly Ala Arg Ser Pro Ser Glu Glu Pro Pro Glu 
            20                  25                  30          


Glu Glu Ile Pro Lys Glu Asp Gly Ile Leu Val Leu Ser Arg His Thr 
        35                  40                  45              


Leu Gly Leu Ala Leu Arg Glu His Pro Ala Leu Leu Val Glu Phe Tyr 
    50                  55                  60                  


Ala Pro Trp Cys Gly His Cys Gln Ala Leu Ala Pro Glu Tyr Ser Lys 
65                  70                  75                  80  


Ala Ala Ala Val Leu Ala Ala Glu Ser Met Val Val Thr Leu Ala Lys 
                85                  90                  95      


Val Asp Gly Pro Ala Gln Arg Glu Leu Ala Glu Glu Phe Gly Val Thr 
            100                 105                 110         


Glu Tyr Pro Thr Leu Lys Phe Phe Arg Asn Gly Asn Arg Thr His Pro 
        115                 120                 125             


Glu Glu Tyr Thr Gly Pro Arg Asp Ala Glu Gly Ile Ala Glu Trp Leu 
    130                 135                 140                 


Arg Arg Arg Val Gly Pro Ser Ala Met Arg Leu Glu Asp Glu Ala Ala 
145                 150                 155                 160 


Ala Gln Ala Leu Ile Gly Gly Arg Asp Leu Val Val Ile Gly Phe Phe 
                165                 170                 175     


Gln Asp Ala Leu Asp Met Thr Phe Gly Leu Thr Asp Arg Pro Arg Leu 
            180                 185                 190         


Phe Gln Gln Phe Gly Leu Thr Lys Asp Thr Val Val Leu Phe Lys Lys 
        195                 200                 205             


Phe Asp Glu Gly Arg Ala Asp Phe Pro Val Asp Glu Glu Leu Gly Leu 
    210                 215                 220                 


Asp Leu Gly 
225         


<210>  10215
<211>  71
<212>  PRT
<213>  Homo Sapiens

<400>  10215

Met Arg Leu Arg Arg Leu Ala Leu Phe Pro Gly Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Arg Leu Ala Ala Ala Ser Asp Val Leu Glu Leu Thr Asp 
            20                  25                  30          


Asp Asn Phe Glu Ser Arg Ile Ser Asp Thr Gly Ser Ala Gly Leu Met 
        35                  40                  45              


Leu Val Glu Phe Phe Ala Pro Cys Ser Ile Pro Ala Gly Phe Glu Glu 
    50                  55                  60                  


Glu Ser Leu Leu Gln Pro His 
65                  70      


<210>  10216
<211>  505
<212>  PRT
<213>  Homo Sapiens

<400>  10216

Met Arg Leu Arg Arg Leu Ala Leu Phe Pro Gly Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Arg Leu Ala Ala Ala Ser Asp Val Leu Glu Leu Thr Asp 
            20                  25                  30          


Asp Asn Phe Glu Ser Arg Ile Ser Asp Thr Gly Ser Ala Gly Leu Met 
        35                  40                  45              


Leu Val Glu Phe Phe Ala Pro Trp Cys Gly His Cys Lys Arg Leu Ala 
    50                  55                  60                  


Pro Glu Tyr Glu Ala Ala Ala Thr Arg Leu Lys Gly Ile Val Pro Leu 
65                  70                  75                  80  


Ala Lys Val Asp Cys Thr Ala Asn Thr Asn Thr Cys Asn Lys Tyr Gly 
                85                  90                  95      


Val Ser Gly Tyr Pro Thr Leu Lys Ile Phe Arg Asp Gly Glu Glu Ala 
            100                 105                 110         


Gly Ala Tyr Asp Gly Pro Arg Thr Ala Asp Gly Ile Val Ser His Leu 
        115                 120                 125             


Lys Lys Gln Ala Gly Pro Ala Ser Val Pro Leu Arg Thr Glu Glu Glu 
    130                 135                 140                 


Phe Lys Lys Phe Ile Ser Asp Lys Asp Ala Ser Ile Val Gly Phe Phe 
145                 150                 155                 160 


Asp Asp Ser Phe Ser Glu Ala His Ser Glu Phe Leu Lys Ala Ala Ser 
                165                 170                 175     


Asn Leu Arg Asp Asn Tyr Arg Phe Ala His Thr Asn Val Glu Ser Leu 
            180                 185                 190         


Val Asn Glu Tyr Asp Asp Asn Gly Glu Gly Ile Ile Leu Phe Arg Pro 
        195                 200                 205             


Ser His Leu Thr Asn Lys Phe Glu Asp Lys Thr Val Ala Tyr Thr Glu 
    210                 215                 220                 


Gln Lys Met Thr Ser Gly Lys Ile Lys Lys Phe Ile Gln Glu Asn Ile 
225                 230                 235                 240 


Phe Gly Ile Cys Pro His Met Thr Glu Asp Asn Lys Asp Leu Ile Gln 
                245                 250                 255     


Gly Lys Asp Leu Leu Ile Ala Tyr Tyr Asp Val Asp Tyr Glu Lys Asn 
            260                 265                 270         


Ala Lys Gly Ser Asn Tyr Trp Arg Asn Arg Val Met Met Val Ala Lys 
        275                 280                 285             


Lys Phe Leu Asp Ala Gly His Lys Leu Asn Phe Ala Val Ala Ser Arg 
    290                 295                 300                 


Lys Thr Phe Ser His Glu Leu Ser Asp Phe Gly Leu Glu Ser Thr Ala 
305                 310                 315                 320 


Gly Glu Ile Pro Val Val Ala Ile Arg Thr Ala Lys Gly Glu Lys Phe 
                325                 330                 335     


Val Met Gln Glu Glu Phe Ser Arg Asp Gly Lys Ala Leu Glu Arg Phe 
            340                 345                 350         


Leu Gln Asp Tyr Phe Asp Gly Asn Leu Lys Arg Tyr Leu Lys Ser Glu 
        355                 360                 365             


Pro Ile Pro Glu Ser Asn Asp Gly Pro Val Lys Val Val Val Ala Glu 
    370                 375                 380                 


Asn Phe Asp Glu Ile Val Asn Asn Glu Asn Lys Asp Val Leu Ile Glu 
385                 390                 395                 400 


Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Asn Leu Glu Pro Lys Tyr 
                405                 410                 415     


Lys Glu Leu Gly Glu Lys Leu Ser Lys Asp Pro Asn Ile Val Ile Ala 
            420                 425                 430         


Lys Met Asp Ala Thr Ala Asn Asp Val Pro Ser Pro Tyr Glu Val Arg 
        435                 440                 445             


Gly Phe Pro Thr Ile Tyr Phe Ser Pro Ala Asn Lys Lys Leu Asn Pro 
    450                 455                 460                 


Lys Lys Tyr Glu Gly Gly Arg Glu Leu Ser Asp Phe Ile Ser Tyr Leu 
465                 470                 475                 480 


Gln Arg Glu Ala Thr Asn Pro Pro Val Ile Gln Glu Glu Lys Pro Lys 
                485                 490                 495     


Lys Lys Lys Lys Ala Gln Glu Asp Leu 
            500                 505 


<210>  10217
<211>  75
<212>  PRT
<213>  Homo Sapiens

<400>  10217

Met Arg Leu Arg Arg Leu Ala Leu Phe Pro Gly Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Arg Leu Ala Ala Ala Ser Asp Val Leu Glu Leu Thr Asp 
            20                  25                  30          


Asp Asn Phe Glu Ser Arg Ile Ser Asp Thr Gly Ser Ala Gly Leu Met 
        35                  40                  45              


Leu Val Glu Phe Phe Ala Pro Trp Leu Gln Asn Ser Pro Ser Gln Arg 
    50                  55                  60                  


Asp Pro Ser Ala Thr Leu Trp Leu Leu Lys Arg 
65                  70                  75  


<210>  10218
<211>  123
<212>  PRT
<213>  Homo Sapiens

<400>  10218

Ser Asp Val Leu Glu Leu Thr Asp Asp Asn Phe Glu Ser Arg Ile Ser 
1               5                   10                  15      


Asp Thr Gly Ser Ala Gly Leu Met Leu Val Glu Phe Phe Ala Pro Trp 
            20                  25                  30          


Cys Gly His Cys Lys Arg Leu Ala Pro Glu Tyr Glu Ala Ala Ala Thr 
        35                  40                  45              


Arg Leu Lys Gly Ile Val Pro Leu Ala Lys Val Asp Cys Thr Ala Asn 
    50                  55                  60                  


Thr Asn Thr Cys Asn Lys Tyr Gly Val Ser Gly Tyr Pro Thr Leu Lys 
65                  70                  75                  80  


Ile Phe Arg Asp Gly Glu Glu Ala Gly Ala Tyr Asp Gly Pro Arg Thr 
                85                  90                  95      


Ala Gly Val Ser Ser Tyr Phe Val Leu His Ile Ser Leu Thr Ser Leu 
            100                 105                 110         


Arg Thr Arg Leu Trp His Ile Gln Ser Lys Lys 
        115                 120             


<210>  10219
<211>  163
<212>  PRT
<213>  Homo Sapiens

<400>  10219

Met Arg Pro Arg Lys Ala Phe Leu Leu Leu Leu Leu Leu Gly Leu Val 
1               5                   10                  15      


Gln Leu Leu Ala Val Ala Gly Ala Glu Gly Pro Asp Glu Asp Phe Arg 
            20                  25                  30          


Gln Val Gln Ala Asn Ser Arg Arg Thr Arg Pro Gly Ser Gly Lys Gly 
        35                  40                  45              


Glu Gly Glu Pro Leu Glu Arg Arg Gly Glu Gly Val Lys Lys Gln Val 
    50                  55                  60                  


Arg Val Leu Trp Asn Ser Lys His Ser Phe Ser Lys Cys Asp Ser Ser 
65                  70                  75                  80  


Asn Arg Glu Asn Ala Ile Glu Asp Glu Glu Glu Glu Glu Glu Glu Asp 
                85                  90                  95      


Asp Asp Glu Glu Glu Asp Asp Leu Glu Val Lys Glu Glu Asn Gly Val 
            100                 105                 110         


Leu Val Leu Asn Asp Ala Asn Phe Asp Asn Phe Val Ala Asp Lys Asp 
        115                 120                 125             


Thr Val Leu Leu Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Gln 
    130                 135                 140                 


Phe Ala Pro Glu Tyr Glu Lys Ile Ala Asn Ile Leu Lys Asp Lys Asp 
145                 150                 155                 160 


Pro Pro Ile 
            


<210>  10220
<211>  645
<212>  PRT
<213>  Homo Sapiens

<400>  10220

Met Arg Pro Arg Lys Ala Phe Leu Leu Leu Leu Leu Leu Gly Leu Val 
1               5                   10                  15      


Gln Leu Leu Ala Val Ala Gly Ala Glu Gly Pro Asp Glu Asp Ser Ser 
            20                  25                  30          


Asn Arg Glu Asn Ala Ile Glu Asp Glu Glu Glu Glu Glu Glu Glu Asp 
        35                  40                  45              


Asp Asp Glu Glu Glu Asp Asp Leu Glu Val Lys Glu Glu Asn Gly Val 
    50                  55                  60                  


Leu Val Leu Asn Asp Ala Asn Phe Asp Asn Phe Val Ala Asp Lys Asp 
65                  70                  75                  80  


Thr Val Leu Leu Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Gln 
                85                  90                  95      


Phe Ala Pro Glu Tyr Glu Lys Ile Ala Asn Ile Leu Lys Asp Lys Asp 
            100                 105                 110         


Pro Pro Ile Pro Val Ala Lys Ile Asp Ala Thr Ser Ala Ser Val Leu 
        115                 120                 125             


Ala Ser Arg Phe Asp Val Ser Gly Tyr Pro Thr Ile Lys Ile Leu Lys 
    130                 135                 140                 


Lys Gly Gln Ala Val Asp Tyr Glu Gly Ser Arg Thr Gln Glu Glu Ile 
145                 150                 155                 160 


Val Ala Lys Val Arg Glu Val Ser Gln Pro Asp Trp Thr Pro Pro Pro 
                165                 170                 175     


Glu Val Thr Leu Val Leu Thr Lys Glu Asn Phe Asp Glu Val Val Asn 
            180                 185                 190         


Asp Ala Asp Ile Ile Leu Val Glu Phe Tyr Ala Pro Trp Cys Gly His 
        195                 200                 205             


Cys Lys Lys Leu Ala Pro Glu Tyr Glu Lys Ala Ala Lys Glu Leu Ser 
    210                 215                 220                 


Lys Arg Ser Pro Pro Ile Pro Leu Ala Lys Val Asp Ala Thr Ala Glu 
225                 230                 235                 240 


Thr Asp Leu Ala Lys Arg Phe Asp Val Ser Gly Tyr Pro Thr Leu Lys 
                245                 250                 255     


Ile Phe Arg Lys Gly Arg Pro Tyr Asp Tyr Asn Gly Pro Arg Glu Lys 
            260                 265                 270         


Tyr Gly Ile Val Asp Tyr Met Ile Glu Gln Ser Gly Pro Pro Ser Lys 
        275                 280                 285             


Glu Ile Leu Thr Leu Lys Gln Val Gln Glu Phe Leu Lys Asp Gly Asp 
    290                 295                 300                 


Asp Val Ile Ile Ile Gly Val Phe Lys Gly Glu Ser Asp Pro Ala Tyr 
305                 310                 315                 320 


Gln Gln Tyr Gln Asp Ala Ala Asn Asn Leu Arg Glu Asp Tyr Lys Phe 
                325                 330                 335     


His His Thr Phe Ser Thr Glu Ile Ala Lys Phe Leu Lys Val Ser Gln 
            340                 345                 350         


Gly Gln Leu Val Val Met Gln Pro Glu Lys Phe Gln Ser Lys Tyr Glu 
        355                 360                 365             


Pro Arg Ser His Met Met Asp Val Gln Gly Ser Thr Gln Asp Ser Ala 
    370                 375                 380                 


Ile Lys Asp Phe Val Leu Lys Tyr Ala Leu Pro Leu Val Gly His Arg 
385                 390                 395                 400 


Lys Val Ser Asn Asp Ala Lys Arg Tyr Thr Arg Arg Pro Leu Val Val 
                405                 410                 415     


Val Tyr Tyr Ser Val Asp Phe Ser Phe Asp Tyr Arg Ala Ala Thr Gln 
            420                 425                 430         


Phe Trp Arg Ser Lys Val Leu Glu Val Ala Lys Asp Phe Pro Glu Tyr 
        435                 440                 445             


Thr Phe Ala Ile Ala Asp Glu Glu Asp Tyr Ala Gly Glu Val Lys Asp 
    450                 455                 460                 


Leu Gly Leu Ser Glu Ser Gly Glu Asp Val Asn Ala Ala Ile Leu Asp 
465                 470                 475                 480 


Glu Ser Gly Lys Lys Phe Ala Met Glu Pro Glu Glu Phe Asp Ser Asp 
                485                 490                 495     


Thr Leu Arg Glu Phe Val Thr Ala Phe Lys Lys Gly Lys Leu Lys Pro 
            500                 505                 510         


Val Ile Lys Ser Gln Pro Val Pro Lys Asn Asn Lys Gly Pro Val Lys 
        515                 520                 525             


Val Val Val Gly Lys Thr Phe Asp Ser Ile Val Met Asp Pro Lys Lys 
    530                 535                 540                 


Asp Val Leu Ile Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Gln 
545                 550                 555                 560 


Leu Glu Pro Val Tyr Asn Ser Leu Ala Lys Lys Tyr Lys Gly Gln Lys 
                565                 570                 575     


Gly Leu Val Ile Ala Lys Met Asp Ala Thr Ala Asn Asp Val Pro Ser 
            580                 585                 590         


Asp Arg Tyr Lys Val Glu Gly Phe Pro Thr Ile Tyr Phe Ala Pro Ser 
        595                 600                 605             


Gly Asp Lys Lys Asn Pro Val Lys Phe Glu Gly Gly Asp Arg Asp Leu 
    610                 615                 620                 


Glu His Leu Ser Lys Phe Ile Glu Glu His Ala Thr Lys Leu Ser Arg 
625                 630                 635                 640 


Thr Lys Glu Glu Leu 
                645 


<210>  10221
<211>  519
<212>  PRT
<213>  Homo Sapiens

<400>  10221

Met Ala Arg Ala Gly Pro Ala Trp Leu Leu Leu Ala Ile Trp Val Val 
1               5                   10                  15      


Leu Pro Ser Trp Leu Ser Ser Ala Lys Val Ser Ser Leu Ile Glu Arg 
            20                  25                  30          


Ile Ser Asp Pro Lys Asp Leu Lys Lys Leu Leu Arg Thr Arg Asn Asn 
        35                  40                  45              


Val Leu Val Leu Tyr Ser Lys Ser Glu Val Ala Ala Glu Asn His Leu 
    50                  55                  60                  


Arg Leu Leu Ser Thr Val Ala Gln Ala Val Lys Gly Gln Gly Thr Ile 
65                  70                  75                  80  


Cys Trp Val Asp Cys Gly Asp Ala Glu Ser Arg Lys Leu Cys Lys Lys 
                85                  90                  95      


Met Lys Val Asp Leu Ser Pro Lys Asp Lys Lys Val Glu Leu Phe His 
            100                 105                 110         


Tyr Gln Asp Gly Ala Phe His Thr Glu Tyr Asn Arg Ala Val Thr Phe 
        115                 120                 125             


Lys Ser Ile Val Ala Phe Leu Lys Asp Pro Lys Gly Pro Pro Leu Trp 
    130                 135                 140                 


Glu Glu Asp Pro Gly Ala Lys Asp Val Val His Leu Asp Ser Glu Lys 
145                 150                 155                 160 


Asp Phe Arg Arg Leu Leu Lys Lys Glu Glu Lys Pro Leu Leu Ile Met 
                165                 170                 175     


Phe Tyr Ala Pro Trp Cys Ser Met Cys Lys Arg Met Met Pro His Phe 
            180                 185                 190         


Gln Lys Ala Ala Thr Gln Leu Arg Gly His Ala Val Leu Ala Gly Met 
        195                 200                 205             


Asn Val Tyr Ser Ser Glu Phe Glu Asn Ile Lys Glu Glu Tyr Ser Val 
    210                 215                 220                 


Arg Gly Phe Pro Thr Ile Cys Tyr Phe Glu Lys Gly Arg Phe Leu Phe 
225                 230                 235                 240 


Gln Tyr Asp Asn Tyr Gly Ser Thr Ala Glu Asp Ile Val Glu Trp Leu 
                245                 250                 255     


Lys Asn Pro Gln Pro Pro Gln Pro Gln Val Pro Glu Thr Pro Trp Ala 
            260                 265                 270         


Asp Glu Gly Gly Ser Val Tyr His Leu Thr Asp Glu Asp Phe Asp Gln 
        275                 280                 285             


Phe Val Lys Glu His Ser Ser Val Leu Val Met Phe His Ala Pro Trp 
    290                 295                 300                 


Cys Gly His Cys Lys Lys Met Lys Pro Glu Phe Glu Lys Ala Ala Glu 
305                 310                 315                 320 


Ala Leu His Gly Glu Ala Asp Ser Ser Gly Val Leu Ala Ala Val Asp 
                325                 330                 335     


Ala Thr Val Asn Lys Ala Leu Ala Glu Arg Phe His Ile Ser Glu Phe 
            340                 345                 350         


Pro Thr Leu Lys Tyr Phe Lys Asn Gly Glu Lys Tyr Ala Val Pro Val 
        355                 360                 365             


Leu Arg Thr Lys Lys Lys Phe Leu Glu Trp Met Gln Asn Pro Glu Ala 
    370                 375                 380                 


Pro Pro Pro Pro Glu Pro Thr Trp Glu Glu Gln Gln Thr Ser Val Leu 
385                 390                 395                 400 


His Leu Val Gly Asp Asn Phe Arg Glu Thr Leu Lys Lys Lys Lys His 
                405                 410                 415     


Thr Leu Val Met Phe Tyr Ala Pro Trp Cys Pro His Cys Lys Lys Val 
            420                 425                 430         


Ile Pro His Phe Thr Ala Thr Ala Asp Ala Phe Lys Asp Asp Arg Lys 
        435                 440                 445             


Ile Ala Cys Ala Ala Val Asp Cys Val Lys Asp Lys Asn Gln Asp Leu 
    450                 455                 460                 


Cys Gln Gln Glu Ala Val Lys Gly Tyr Pro Thr Phe His Tyr Tyr His 
465                 470                 475                 480 


Tyr Gly Lys Phe Ala Glu Lys Tyr Asp Ser Asp Arg Thr Glu Leu Gly 
                485                 490                 495     


Phe Thr Asn Tyr Ile Arg Ala Leu Arg Glu Gly Asp His Glu Arg Leu 
            500                 505                 510         


Gly Lys Lys Lys Glu Glu Leu 
        515                 


<210>  10222
<211>  262
<212>  PRT
<213>  Homo Sapiens

<400>  10222

Met Ala Arg Ala Gly Pro Ala Trp Leu Leu Leu Ala Ile Trp Val Val 
1               5                   10                  15      


Leu Pro Ser Trp Leu Ser Ser Ala Lys Val Ser Ser Leu Ile Glu Arg 
            20                  25                  30          


Ile Ser Asp Pro Lys Asp Leu Lys Lys Leu Leu Arg Thr Arg Asn Asn 
        35                  40                  45              


Val Leu Val Leu Tyr Ser Lys Ser Glu Val Ala Ala Glu Asn His Leu 
    50                  55                  60                  


Arg Leu Leu Ser Thr Val Ala Gln Ala Val Lys Gly Gln Gly Thr Ile 
65                  70                  75                  80  


Cys Trp Val Asp Cys Gly Asp Ala Glu Ser Arg Lys Leu Cys Lys Lys 
                85                  90                  95      


Met Lys Val Asp Leu Ser Pro Lys Asp Lys Lys Val Glu Leu Phe His 
            100                 105                 110         


Tyr Gln Asp Gly Ala Phe His Thr Glu Tyr Asn Arg Ala Val Thr Phe 
        115                 120                 125             


Lys Ser Ile Val Ala Phe Leu Lys Asp Pro Lys Gly Pro Pro Leu Trp 
    130                 135                 140                 


Glu Glu Asp Pro Gly Ala Lys Asp Val Val His Leu Asp Ser Glu Lys 
145                 150                 155                 160 


Asp Phe Arg Arg Leu Leu Lys Lys Glu Glu Lys Pro Leu Leu Ile Met 
                165                 170                 175     


Phe Tyr Ala Pro Trp Cys Ser Met Cys Lys Arg Met Met Pro His Phe 
            180                 185                 190         


Gln Lys Ala Ala Thr Gln Leu Arg Gly His Ala Val Leu Ala Gly Met 
        195                 200                 205             


Asn Val Tyr Ser Ser Glu Phe Glu Asn Ile Lys Glu Glu Tyr Ser Val 
    210                 215                 220                 


Arg Gly Phe Pro Thr Ile Cys Tyr Phe Glu Lys Gly Arg Phe Leu Phe 
225                 230                 235                 240 


Gln Tyr Asp Asn Tyr Gly Ser Thr Ala Glu Asp Ile Val Glu Trp Leu 
                245                 250                 255     


Lys Lys Val Trp Pro Leu 
            260         


<210>  10223
<211>  64
<212>  PRT
<213>  Homo Sapiens

<400>  10223

Met Lys Val Asp Leu Ser Pro Lys Asp Lys Lys Val Glu Leu Phe His 
1               5                   10                  15      


Tyr Gln Asp Gly Ala Phe His Thr Glu Tyr Asn Arg Ala Val Thr Phe 
            20                  25                  30          


Lys Ser Ile Val Ala Phe Leu Lys Asp Pro Lys Gly Pro Pro Leu Trp 
        35                  40                  45              


Glu Glu Asp Pro Gly Ala Lys Asp Val Val His Leu Asp Ser Glu Lys 
    50                  55                  60                  


<210>  10224
<211>  83
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  10224

Xaa Thr Leu Val Met Phe Tyr Ala Pro Trp Cys Pro His Cys Lys Lys 
1               5                   10                  15      


Val Ile Pro His Phe Thr Ala Thr Ala Asp Ala Phe Lys Asp Asp Arg 
            20                  25                  30          


Lys Ile Ala Cys Ala Ala Val Asp Cys Val Lys Asp Lys Asn Gln Asp 
        35                  40                  45              


Leu Cys Gln Gln Glu Ala Val Lys Gly Tyr Pro Thr Phe His Tyr Tyr 
    50                  55                  60                  


His Tyr Gly Lys Phe Ala Glu Lys Tyr Asp Ser Asp Arg Thr Val Phe 
65                  70                  75                  80  


Ser Val Gly 
            


<210>  10225
<211>  440
<212>  PRT
<213>  Homo Sapiens

<400>  10225

Met Ala Leu Leu Val Leu Gly Leu Val Ser Cys Thr Phe Phe Leu Ala 
1               5                   10                  15      


Val Asn Gly Leu Tyr Ser Ser Ser Asp Asp Val Ile Glu Leu Thr Pro 
            20                  25                  30          


Ser Asn Phe Asn Arg Glu Val Ile Gln Ser Asp Ser Leu Trp Leu Val 
        35                  40                  45              


Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Gln Arg Leu Thr Pro Glu 
    50                  55                  60                  


Trp Lys Lys Ala Ala Thr Ala Leu Lys Asp Val Val Lys Val Gly Ala 
65                  70                  75                  80  


Val Asp Ala Asp Lys His His Ser Leu Gly Gly Gln Tyr Gly Val Gln 
                85                  90                  95      


Gly Phe Pro Thr Ile Lys Ile Phe Gly Ser Asn Lys Asn Arg Pro Glu 
            100                 105                 110         


Asp Tyr Gln Gly Gly Arg Thr Gly Glu Ala Ile Val Asp Ala Ala Leu 
        115                 120                 125             


Ser Ala Leu Arg Gln Leu Val Lys Asp Arg Leu Gly Gly Arg Ser Gly 
    130                 135                 140                 


Gly Tyr Ser Ser Gly Lys Gln Gly Arg Ser Asp Ser Ser Ser Lys Lys 
145                 150                 155                 160 


Asp Val Ile Glu Leu Thr Asp Asp Ser Phe Asp Lys Asn Val Leu Asp 
                165                 170                 175     


Ser Glu Asp Val Trp Met Val Glu Phe Tyr Ala Pro Trp Cys Gly His 
            180                 185                 190         


Cys Lys Asn Leu Glu Pro Glu Trp Ala Ala Ala Ala Ser Glu Val Lys 
        195                 200                 205             


Glu Gln Thr Lys Gly Lys Val Lys Leu Ala Ala Val Asp Ala Thr Val 
    210                 215                 220                 


Asn Gln Val Leu Ala Ser Arg Tyr Gly Ile Arg Gly Phe Pro Thr Ile 
225                 230                 235                 240 


Lys Ile Phe Gln Lys Gly Glu Ser Pro Val Asp Tyr Asp Gly Gly Arg 
                245                 250                 255     


Thr Arg Ser Asp Ile Val Ser Arg Ala Leu Asp Leu Phe Ser Asp Asn 
            260                 265                 270         


Ala Pro Pro Pro Glu Leu Leu Glu Ile Ile Asn Glu Asp Ile Ala Lys 
        275                 280                 285             


Arg Thr Cys Glu Glu His Gln Leu Cys Val Val Ala Val Leu Pro His 
    290                 295                 300                 


Ile Leu Asp Thr Gly Ala Ala Gly Arg Asn Ser Tyr Leu Glu Val Leu 
305                 310                 315                 320 


Leu Lys Leu Ala Asp Lys Tyr Lys Lys Lys Met Trp Gly Trp Leu Trp 
                325                 330                 335     


Thr Glu Ala Gly Ala Gln Ser Glu Leu Glu Thr Ala Leu Gly Ile Gly 
            340                 345                 350         


Gly Phe Gly Tyr Pro Ala Met Ala Ala Ile Asn Ala Arg Lys Met Lys 
        355                 360                 365             


Phe Ala Leu Leu Lys Gly Ser Phe Ser Glu Gln Gly Ile Asn Glu Phe 
    370                 375                 380                 


Leu Arg Glu Leu Ser Phe Gly Arg Gly Ser Thr Ala Pro Val Gly Gly 
385                 390                 395                 400 


Gly Ala Phe Pro Thr Ile Val Glu Arg Glu Pro Trp Asp Gly Arg Asp 
                405                 410                 415     


Gly Glu Leu Pro Val Glu Asp Asp Ile Asp Leu Ser Asp Val Glu Leu 
            420                 425                 430         


Asp Asp Leu Gly Lys Asp Glu Leu 
        435                 440 


<210>  10226
<211>  437
<212>  PRT
<213>  Homo Sapiens

<400>  10226

Met Ile Leu Gly Leu Val Ser Cys Thr Phe Phe Leu Ala Val Asn Gly 
1               5                   10                  15      


Leu Tyr Ser Ser Ser Asp Asp Val Ile Glu Leu Thr Pro Ser Asn Phe 
            20                  25                  30          


Asn Arg Glu Val Ile Gln Ser Asp Ser Leu Trp Leu Val Glu Phe Tyr 
        35                  40                  45              


Ala Pro Trp Cys Gly His Cys Gln Arg Leu Thr Pro Glu Trp Lys Lys 
    50                  55                  60                  


Ala Ala Thr Ala Leu Lys Asp Val Val Lys Val Gly Ala Val Asp Ala 
65                  70                  75                  80  


Asp Lys His His Ser Leu Gly Gly Gln Tyr Gly Val Gln Gly Phe Pro 
                85                  90                  95      


Thr Ile Lys Ile Phe Gly Ser Asn Lys Asn Arg Pro Glu Asp Tyr Gln 
            100                 105                 110         


Gly Gly Arg Thr Gly Glu Ala Ile Val Asp Ala Ala Leu Ser Ala Leu 
        115                 120                 125             


Arg Gln Leu Val Lys Asp Arg Leu Gly Gly Arg Ser Gly Gly Tyr Ser 
    130                 135                 140                 


Ser Gly Lys Gln Gly Arg Ser Asp Ser Ser Ser Lys Lys Asp Val Ile 
145                 150                 155                 160 


Glu Leu Thr Asp Asp Ser Phe Asp Lys Asn Val Leu Asp Ser Glu Asp 
                165                 170                 175     


Val Trp Met Val Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Asn 
            180                 185                 190         


Leu Glu Pro Glu Trp Ala Ala Ala Ala Ser Glu Val Lys Glu Gln Thr 
        195                 200                 205             


Lys Gly Lys Val Lys Leu Ala Ala Val Asp Ala Thr Val Asn Gln Val 
    210                 215                 220                 


Leu Ala Ser Arg Tyr Gly Ile Arg Gly Phe Pro Thr Ile Lys Ile Phe 
225                 230                 235                 240 


Gln Lys Gly Glu Ser Pro Val Asp Tyr Asp Gly Gly Arg Thr Arg Ser 
                245                 250                 255     


Asp Ile Val Ser Arg Ala Leu Asp Leu Phe Ser Asp Asn Ala Pro Pro 
            260                 265                 270         


Pro Glu Leu Leu Glu Ile Ile Asn Glu Asp Ile Ala Lys Arg Thr Cys 
        275                 280                 285             


Glu Glu His Gln Leu Cys Val Val Ala Val Leu Pro His Ile Leu Asp 
    290                 295                 300                 


Thr Gly Ala Ala Gly Arg Asn Ser Tyr Leu Glu Val Leu Leu Lys Leu 
305                 310                 315                 320 


Ala Asp Lys Tyr Lys Lys Lys Met Trp Gly Trp Leu Trp Thr Glu Ala 
                325                 330                 335     


Gly Ala Gln Ser Glu Leu Glu Thr Ala Leu Gly Ile Gly Gly Phe Gly 
            340                 345                 350         


Tyr Pro Ala Met Ala Ala Ile Asn Ala Arg Lys Met Lys Phe Ala Leu 
        355                 360                 365             


Leu Lys Gly Ser Phe Ser Glu Gln Gly Ile Asn Glu Phe Leu Arg Glu 
    370                 375                 380                 


Leu Ser Phe Gly Arg Gly Ser Thr Ala Pro Val Gly Gly Gly Ala Phe 
385                 390                 395                 400 


Pro Thr Ile Val Glu Arg Glu Pro Trp Asp Gly Arg Asp Gly Glu Leu 
                405                 410                 415     


Pro Val Glu Asp Asp Ile Asp Leu Ser Asp Val Glu Leu Asp Asp Leu 
            420                 425                 430         


Gly Lys Asp Glu Leu 
        435         


<210>  10227
<211>  488
<212>  PRT
<213>  Homo Sapiens

<400>  10227

Met Arg Ile Ile Thr Ala Pro Ala Ser Lys Val Ser Arg Gly Ser Asn 
1               5                   10                  15      


Glu Leu Met Ile Leu Ala Arg Arg Ser Asp Arg Gly Ser Pro Thr Ser 
            20                  25                  30          


Pro Ala His Ser Leu Ser Arg Lys Ser Pro Ile Met Tyr Pro Ser Thr 
        35                  40                  45              


Thr Met Ala Asn Ala Pro Gly Leu Val Ser Cys Thr Phe Phe Leu Ala 
    50                  55                  60                  


Val Asn Gly Leu Tyr Ser Ser Ser Asp Asp Val Ile Glu Leu Thr Pro 
65                  70                  75                  80  


Ser Asn Phe Asn Arg Glu Val Ile Gln Ser Asp Ser Leu Trp Leu Val 
                85                  90                  95      


Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Gln Arg Leu Thr Pro Glu 
            100                 105                 110         


Trp Lys Lys Ala Ala Thr Ala Leu Lys Asp Val Val Lys Val Gly Ala 
        115                 120                 125             


Val Asp Ala Asp Lys His His Ser Leu Gly Gly Gln Tyr Gly Val Gln 
    130                 135                 140                 


Gly Phe Pro Thr Ile Lys Ile Phe Gly Ser Asn Lys Asn Arg Pro Glu 
145                 150                 155                 160 


Asp Tyr Gln Gly Gly Arg Thr Gly Glu Ala Ile Val Asp Ala Ala Leu 
                165                 170                 175     


Ser Ala Leu Arg Gln Leu Val Lys Asp Arg Leu Gly Gly Arg Ser Gly 
            180                 185                 190         


Gly Tyr Ser Ser Gly Lys Gln Gly Arg Ser Asp Ser Ser Ser Lys Lys 
        195                 200                 205             


Asp Val Ile Glu Leu Thr Asp Asp Ser Phe Asp Lys Asn Val Leu Asp 
    210                 215                 220                 


Ser Glu Asp Val Trp Met Val Glu Phe Tyr Ala Pro Trp Cys Gly His 
225                 230                 235                 240 


Cys Lys Asn Leu Glu Pro Glu Trp Ala Ala Ala Ala Ser Glu Val Lys 
                245                 250                 255     


Glu Gln Thr Lys Gly Lys Val Lys Leu Ala Ala Val Asp Ala Thr Val 
            260                 265                 270         


Asn Gln Val Leu Ala Ser Arg Tyr Gly Ile Arg Gly Phe Pro Thr Ile 
        275                 280                 285             


Lys Ile Phe Gln Lys Gly Glu Ser Pro Val Asp Tyr Asp Gly Gly Arg 
    290                 295                 300                 


Thr Arg Ser Asp Ile Val Ser Arg Ala Leu Asp Leu Phe Ser Asp Asn 
305                 310                 315                 320 


Ala Pro Pro Pro Glu Leu Leu Glu Ile Ile Asn Glu Asp Ile Ala Lys 
                325                 330                 335     


Arg Thr Cys Glu Glu His Gln Leu Cys Val Val Ala Val Leu Pro His 
            340                 345                 350         


Ile Leu Asp Thr Gly Ala Ala Gly Arg Asn Ser Tyr Leu Glu Val Leu 
        355                 360                 365             


Leu Lys Leu Ala Asp Lys Tyr Lys Lys Lys Met Trp Gly Trp Leu Trp 
    370                 375                 380                 


Thr Glu Ala Gly Ala Gln Ser Glu Leu Glu Thr Ala Leu Gly Ile Gly 
385                 390                 395                 400 


Gly Phe Gly Tyr Pro Ala Met Ala Ala Ile Asn Ala Arg Lys Met Lys 
                405                 410                 415     


Phe Ala Leu Leu Lys Gly Ser Phe Ser Glu Gln Gly Ile Asn Glu Phe 
            420                 425                 430         


Leu Arg Glu Leu Ser Phe Gly Arg Gly Ser Thr Ala Pro Val Gly Gly 
        435                 440                 445             


Gly Ala Phe Pro Thr Ile Val Glu Arg Glu Pro Trp Asp Gly Arg Asp 
    450                 455                 460                 


Gly Glu Leu Pro Val Glu Asp Asp Ile Asp Leu Ser Asp Val Glu Leu 
465                 470                 475                 480 


Asp Asp Leu Gly Lys Asp Glu Leu 
                485             


<210>  10228
<211>  492
<212>  PRT
<213>  Homo Sapiens

<400>  10228

Met Arg Arg Asp Leu Arg Glu Lys Leu Val Trp Val Cys Arg Pro Leu 
1               5                   10                  15      


Ala Pro Val Glu Val Pro Ala Asn Ile Ser Ser Asp Phe Gln Pro Cys 
            20                  25                  30          


Ser Pro Thr Ser Pro Ala His Ser Leu Ser Arg Lys Ser Pro Ile Met 
        35                  40                  45              


Tyr Pro Ser Thr Thr Met Ala Asn Ala Pro Gly Leu Val Ser Cys Thr 
    50                  55                  60                  


Phe Phe Leu Ala Val Asn Gly Leu Tyr Ser Ser Ser Asp Asp Val Ile 
65                  70                  75                  80  


Glu Leu Thr Pro Ser Asn Phe Asn Arg Glu Val Ile Gln Ser Asp Ser 
                85                  90                  95      


Leu Trp Leu Val Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Gln Arg 
            100                 105                 110         


Leu Thr Pro Glu Trp Lys Lys Ala Ala Thr Ala Leu Lys Asp Val Val 
        115                 120                 125             


Lys Val Gly Ala Val Asp Ala Asp Lys His His Ser Leu Gly Gly Gln 
    130                 135                 140                 


Tyr Gly Val Gln Gly Phe Pro Thr Ile Lys Ile Phe Gly Ser Asn Lys 
145                 150                 155                 160 


Asn Arg Pro Glu Asp Tyr Gln Gly Gly Arg Thr Gly Glu Ala Ile Val 
                165                 170                 175     


Asp Ala Ala Leu Ser Ala Leu Arg Gln Leu Val Lys Asp Arg Leu Gly 
            180                 185                 190         


Gly Arg Ser Gly Gly Tyr Ser Ser Gly Lys Gln Gly Arg Ser Asp Ser 
        195                 200                 205             


Ser Ser Lys Lys Asp Val Ile Glu Leu Thr Asp Asp Ser Phe Asp Lys 
    210                 215                 220                 


Asn Val Leu Asp Ser Glu Asp Val Trp Met Val Glu Phe Tyr Ala Pro 
225                 230                 235                 240 


Trp Cys Gly His Cys Lys Asn Leu Glu Pro Glu Trp Ala Ala Ala Ala 
                245                 250                 255     


Ser Glu Val Lys Glu Gln Thr Lys Gly Lys Val Lys Leu Ala Ala Val 
            260                 265                 270         


Asp Ala Thr Val Asn Gln Val Leu Ala Ser Arg Tyr Gly Ile Arg Gly 
        275                 280                 285             


Phe Pro Thr Ile Lys Ile Phe Gln Lys Gly Glu Ser Pro Val Asp Tyr 
    290                 295                 300                 


Asp Gly Gly Arg Thr Arg Ser Asp Ile Val Ser Arg Ala Leu Asp Leu 
305                 310                 315                 320 


Phe Ser Asp Asn Ala Pro Pro Pro Glu Leu Leu Glu Ile Ile Asn Glu 
                325                 330                 335     


Asp Ile Ala Lys Arg Thr Cys Glu Glu His Gln Leu Cys Val Val Ala 
            340                 345                 350         


Val Leu Pro His Ile Leu Asp Thr Gly Ala Ala Gly Arg Asn Ser Tyr 
        355                 360                 365             


Leu Glu Val Leu Leu Lys Leu Ala Asp Lys Tyr Lys Lys Lys Met Trp 
    370                 375                 380                 


Gly Trp Leu Trp Thr Glu Ala Gly Ala Gln Ser Glu Leu Glu Thr Ala 
385                 390                 395                 400 


Leu Gly Ile Gly Gly Phe Gly Tyr Pro Ala Met Ala Ala Ile Asn Ala 
                405                 410                 415     


Arg Lys Met Lys Phe Ala Leu Leu Lys Gly Ser Phe Ser Glu Gln Gly 
            420                 425                 430         


Ile Asn Glu Phe Leu Arg Glu Leu Ser Phe Gly Arg Gly Ser Thr Ala 
        435                 440                 445             


Pro Val Gly Gly Gly Ala Phe Pro Thr Ile Val Glu Arg Glu Pro Trp 
    450                 455                 460                 


Asp Gly Arg Asp Gly Glu Leu Pro Val Glu Asp Asp Ile Asp Leu Ser 
465                 470                 475                 480 


Asp Val Glu Leu Asp Asp Leu Gly Lys Asp Glu Leu 
                485                 490         


<210>  10229
<211>  492
<212>  PRT
<213>  Homo Sapiens

<400>  10229

Met Arg Arg Asp Leu Arg Glu Lys Leu Val Trp Val Cys Arg Pro Leu 
1               5                   10                  15      


Ala Pro Val Glu Val Pro Ala Asn Ile Ser Ser Asp Phe Gln Pro Cys 
            20                  25                  30          


Ser Pro Thr Ser Pro Ala His Ser Leu Ser Arg Lys Ser Pro Ile Met 
        35                  40                  45              


Tyr Pro Ser Thr Thr Met Ala Asn Ala Pro Gly Leu Val Ser Cys Thr 
    50                  55                  60                  


Phe Phe Leu Ala Val Asn Gly Leu Tyr Ser Ser Ser Asp Asp Val Ile 
65                  70                  75                  80  


Glu Leu Thr Pro Ser Asn Phe Asn Arg Glu Val Ile Gln Ser Asp Ser 
                85                  90                  95      


Leu Trp Leu Val Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Gln Arg 
            100                 105                 110         


Leu Thr Pro Glu Trp Lys Lys Ala Ala Thr Ala Leu Lys Asp Val Val 
        115                 120                 125             


Lys Val Gly Ala Val Asp Ala Asp Lys His His Ser Leu Gly Gly Gln 
    130                 135                 140                 


Tyr Gly Val Gln Gly Phe Pro Thr Ile Lys Ile Phe Gly Ser Asn Lys 
145                 150                 155                 160 


Asn Arg Pro Glu Asp Tyr Gln Gly Gly Arg Thr Gly Glu Ala Ile Val 
                165                 170                 175     


Asp Ala Ala Leu Ser Ala Leu Arg Gln Leu Val Lys Asp Arg Leu Gly 
            180                 185                 190         


Gly Arg Ser Gly Gly Tyr Ser Ser Gly Lys Gln Gly Arg Ser Asp Ser 
        195                 200                 205             


Ser Ser Lys Lys Asp Val Ile Glu Leu Thr Asp Asp Ser Phe Asp Lys 
    210                 215                 220                 


Asn Val Leu Asp Ser Glu Asp Val Trp Met Val Glu Phe Tyr Ala Pro 
225                 230                 235                 240 


Trp Cys Gly His Cys Lys Asn Leu Glu Pro Glu Trp Ala Ala Ala Ala 
                245                 250                 255     


Ser Glu Val Lys Glu Gln Thr Lys Gly Lys Val Lys Leu Ala Ala Val 
            260                 265                 270         


Asp Ala Thr Val Asn Gln Val Leu Ala Ser Arg Tyr Gly Ile Arg Gly 
        275                 280                 285             


Phe Pro Thr Ile Lys Ile Phe Gln Lys Gly Glu Ser Pro Val Asp Tyr 
    290                 295                 300                 


Asp Gly Gly Arg Thr Arg Ser Asp Ile Val Ser Arg Ala Leu Asp Leu 
305                 310                 315                 320 


Phe Ser Asp Asn Ala Pro Pro Pro Glu Leu Leu Glu Ile Ile Asn Glu 
                325                 330                 335     


Asp Ile Ala Lys Arg Thr Cys Glu Glu His Gln Leu Cys Val Val Ala 
            340                 345                 350         


Val Leu Pro His Ile Leu Asp Thr Gly Ala Ala Gly Arg Asn Ser Tyr 
        355                 360                 365             


Leu Glu Val Leu Leu Lys Leu Ala Asp Lys Tyr Lys Lys Lys Met Trp 
    370                 375                 380                 


Gly Trp Leu Trp Thr Glu Ala Gly Ala Gln Ser Glu Leu Glu Thr Ala 
385                 390                 395                 400 


Leu Gly Ile Gly Gly Phe Gly Tyr Pro Ala Met Ala Ala Ile Asn Ala 
                405                 410                 415     


Arg Lys Met Lys Phe Ala Leu Leu Lys Gly Ser Phe Ser Glu Gln Gly 
            420                 425                 430         


Ile Asn Glu Phe Leu Arg Glu Leu Ser Phe Gly Arg Gly Ser Thr Ala 
        435                 440                 445             


Pro Val Gly Gly Gly Ala Phe Pro Thr Ile Val Glu Arg Glu Pro Trp 
    450                 455                 460                 


Asp Gly Arg Asp Gly Glu Leu Pro Val Glu Asp Asp Ile Asp Leu Ser 
465                 470                 475                 480 


Asp Val Glu Leu Asp Asp Leu Gly Lys Asp Glu Leu 
                485                 490         


<210>  10230
<211>  11
<212>  PRT
<213>  Homo Sapiens

<400>  10230

Met Tyr Pro Ser Thr Thr Met Ala Asn Ala Pro 
1               5                   10      


<210>  10231
<211>  445
<212>  PRT
<213>  Homo Sapiens

<400>  10231

Met Tyr Pro Ser Thr Thr Met Ala Asn Ala Pro Gly Leu Val Ser Cys 
1               5                   10                  15      


Thr Phe Phe Leu Ala Val Asn Gly Leu Tyr Ser Ser Ser Asp Asp Val 
            20                  25                  30          


Ile Glu Leu Thr Pro Ser Asn Phe Asn Arg Glu Val Ile Gln Ser Asp 
        35                  40                  45              


Ser Leu Trp Leu Val Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Gln 
    50                  55                  60                  


Arg Leu Thr Pro Glu Trp Lys Lys Ala Ala Thr Ala Leu Lys Asp Val 
65                  70                  75                  80  


Val Lys Val Gly Ala Val Asp Ala Asp Lys His His Ser Leu Gly Gly 
                85                  90                  95      


Gln Tyr Gly Val Gln Gly Phe Pro Thr Ile Lys Ile Phe Gly Ser Asn 
            100                 105                 110         


Lys Asn Arg Pro Glu Asp Tyr Gln Gly Gly Arg Thr Gly Glu Ala Ile 
        115                 120                 125             


Val Asp Ala Ala Leu Ser Ala Leu Arg Gln Leu Val Lys Asp Arg Leu 
    130                 135                 140                 


Gly Gly Arg Ser Gly Gly Tyr Ser Ser Gly Lys Gln Gly Arg Ser Asp 
145                 150                 155                 160 


Ser Ser Ser Lys Lys Asp Val Ile Glu Leu Thr Asp Asp Ser Phe Asp 
                165                 170                 175     


Lys Asn Val Leu Asp Ser Glu Asp Val Trp Met Val Glu Phe Tyr Ala 
            180                 185                 190         


Pro Trp Cys Gly His Cys Lys Asn Leu Glu Pro Glu Trp Ala Ala Ala 
        195                 200                 205             


Ala Ser Glu Val Lys Glu Gln Thr Lys Gly Lys Val Lys Leu Ala Ala 
    210                 215                 220                 


Val Asp Ala Thr Val Asn Gln Val Leu Ala Ser Arg Tyr Gly Ile Arg 
225                 230                 235                 240 


Gly Phe Pro Thr Ile Lys Ile Phe Gln Lys Gly Glu Ser Pro Val Asp 
                245                 250                 255     


Tyr Asp Gly Gly Arg Thr Arg Ser Asp Ile Val Ser Arg Ala Leu Asp 
            260                 265                 270         


Leu Phe Ser Asp Asn Ala Pro Pro Pro Glu Leu Leu Glu Ile Ile Asn 
        275                 280                 285             


Glu Asp Ile Ala Lys Arg Thr Cys Glu Glu His Gln Leu Cys Val Val 
    290                 295                 300                 


Ala Val Leu Pro His Ile Leu Asp Thr Gly Ala Ala Gly Arg Asn Ser 
305                 310                 315                 320 


Tyr Leu Glu Val Leu Leu Lys Leu Ala Asp Lys Tyr Lys Lys Lys Met 
                325                 330                 335     


Trp Gly Trp Leu Trp Thr Glu Ala Gly Ala Gln Ser Glu Leu Glu Thr 
            340                 345                 350         


Ala Leu Gly Ile Gly Gly Phe Gly Tyr Pro Ala Met Ala Ala Ile Asn 
        355                 360                 365             


Ala Arg Lys Met Lys Phe Ala Leu Leu Lys Gly Ser Phe Ser Glu Gln 
    370                 375                 380                 


Gly Ile Asn Glu Phe Leu Arg Glu Leu Ser Phe Gly Arg Gly Ser Thr 
385                 390                 395                 400 


Ala Pro Val Gly Gly Gly Ala Phe Pro Thr Ile Val Glu Arg Glu Pro 
                405                 410                 415     


Trp Asp Gly Arg Asp Gly Glu Leu Pro Val Glu Asp Asp Ile Asp Leu 
            420                 425                 430         


Ser Asp Val Glu Leu Asp Asp Leu Gly Lys Asp Glu Leu 
        435                 440                 445 


<210>  10232
<211>  177
<212>  PRT
<213>  Homo Sapiens

<400>  10232

Met Asp Leu Leu Trp Met Pro Leu Leu Leu Val Ala Ala Cys Val Ser 
1               5                   10                  15      


Ala Val His Ser Ser Pro Glu Val Asn Ala Gly Val Ser Ser Ile His 
            20                  25                  30          


Ile Thr Lys Pro Val His Ile Leu Glu Glu Arg Ser Leu Leu Val Leu 
        35                  40                  45              


Thr Pro Ala Gly Leu Thr Gln Met Leu Asn Gln Thr Arg Phe Leu Met 
    50                  55                  60                  


Val Leu Phe His Glu Val Leu Leu Leu Leu Pro Arg Leu Lys Tyr Asn 
65                  70                  75                  80  


Gly Ala Ile Leu Ala His Arg Asn Leu His Leu Pro Gly Ser Ser Asp 
                85                  90                  95      


Ser Pro Ala Ser Ala Ser Gln Val Ala Gly Ile Thr Asp Asn Pro Ser 
            100                 105                 110         


Ser Lys Gln Ser Arg Asn Leu Ala Glu Glu Leu Gly Lys Ala Val Glu 
        115                 120                 125             


Ile Met Gly Lys Gly Lys Asn Gly Ile Gly Phe Gly Lys Val Asp Ile 
    130                 135                 140                 


Thr Ile Glu Lys Glu Leu Gln Gln Glu Phe Gly Ile Thr Lys Ala Pro 
145                 150                 155                 160 


Glu Leu Lys Leu Phe Phe Glu Gly Asn Arg Ser Glu Pro Ile Ser Cys 
                165                 170                 175     


Lys 
    


<210>  10233
<211>  584
<212>  PRT
<213>  Homo Sapiens

<400>  10233

Met Asp Leu Leu Trp Met Pro Leu Leu Leu Val Ala Ala Cys Val Ser 
1               5                   10                  15      


Ala Val His Ser Ser Pro Glu Val Asn Ala Gly Val Ser Ser Ile His 
            20                  25                  30          


Ile Thr Lys Pro Val His Ile Leu Glu Glu Arg Ser Leu Leu Val Leu 
        35                  40                  45              


Thr Pro Ala Gly Leu Thr Gln Met Leu Asn Gln Thr Arg Phe Leu Met 
    50                  55                  60                  


Val Leu Phe His Asn Pro Ser Ser Lys Gln Ser Arg Asn Leu Ala Glu 
65                  70                  75                  80  


Glu Leu Gly Lys Ala Val Glu Ile Met Gly Lys Gly Lys Asn Gly Ile 
                85                  90                  95      


Gly Phe Gly Lys Val Asp Ile Thr Ile Glu Lys Glu Leu Gln Gln Glu 
            100                 105                 110         


Phe Gly Ile Thr Lys Ala Pro Glu Leu Lys Leu Phe Phe Glu Gly Asn 
        115                 120                 125             


Arg Ser Glu Pro Ile Ser Cys Lys Gly Val Val Glu Ser Ala Ala Leu 
    130                 135                 140                 


Val Val Trp Leu Arg Arg Gln Ile Ser Gln Lys Ala Phe Leu Phe Asn 
145                 150                 155                 160 


Ser Ser Glu Gln Val Ala Glu Phe Val Ile Ser Arg Pro Leu Val Ile 
                165                 170                 175     


Val Gly Phe Phe Gln Asp Leu Glu Glu Glu Val Ala Glu Leu Phe Tyr 
            180                 185                 190         


Asp Val Ile Lys Asp Phe Pro Glu Leu Thr Phe Gly Val Ile Thr Ile 
        195                 200                 205             


Gly Asn Val Ile Gly Arg Phe His Val Thr Leu Asp Ser Val Leu Val 
    210                 215                 220                 


Phe Lys Lys Gly Lys Ile Val Asn Arg Gln Lys Leu Ile Asn Asp Ser 
225                 230                 235                 240 


Thr Asn Lys Gln Glu Leu Asn Arg Val Ile Lys Gln His Leu Thr Asp 
                245                 250                 255     


Phe Val Ile Glu Tyr Asn Thr Glu Asn Lys Asp Leu Ile Ser Glu Leu 
            260                 265                 270         


His Ile Met Ser His Met Leu Leu Phe Val Ser Lys Ser Ser Glu Ser 
        275                 280                 285             


Tyr Gly Ile Ile Ile Gln His Tyr Lys Leu Ala Ser Lys Glu Phe Gln 
    290                 295                 300                 


Asn Lys Ile Leu Phe Ile Leu Val Asp Ala Asp Glu Pro Arg Asn Gly 
305                 310                 315                 320 


Arg Val Phe Lys Tyr Phe Arg Val Thr Glu Val Asp Ile Pro Ser Val 
                325                 330                 335     


Gln Ile Leu Asn Leu Ser Ser Asp Ala Arg Tyr Lys Met Pro Ser Asp 
            340                 345                 350         


Asp Ile Thr Tyr Glu Ser Leu Lys Lys Phe Gly Arg Ser Phe Leu Ser 
        355                 360                 365             


Lys Asn Ala Thr Lys His Gln Ser Ser Glu Glu Ile Pro Lys Tyr Trp 
    370                 375                 380                 


Asp Gln Gly Leu Val Lys Gln Leu Val Gly Lys Asn Phe Asn Val Val 
385                 390                 395                 400 


Val Phe Asp Lys Glu Lys Asp Val Phe Val Met Phe Tyr Ala Pro Trp 
                405                 410                 415     


Ser Lys Lys Cys Lys Met Leu Phe Pro Leu Leu Glu Glu Leu Gly Arg 
            420                 425                 430         


Lys Tyr Gln Asn His Ser Thr Ile Ile Ile Ala Lys Ile Asp Val Thr 
        435                 440                 445             


Ala Asn Asp Ile Gln Leu Met Tyr Leu Asp Arg Tyr Pro Phe Phe Arg 
    450                 455                 460                 


Leu Phe Pro Ser Gly Ser Gln Gln Ala Val Leu Tyr Lys Gly Glu His 
465                 470                 475                 480 


Thr Leu Lys Gly Phe Ser Asp Phe Leu Glu Ser His Ile Lys Thr Lys 
                485                 490                 495     


Ile Glu Asp Glu Asp Glu Leu Leu Ser Val Glu Gln Asn Glu Val Ile 
            500                 505                 510         


Glu Glu Glu Val Leu Ala Glu Glu Lys Glu Val Pro Met Met Arg Lys 
        515                 520                 525             


Gly Leu Pro Glu Gln Gln Ser Pro Glu Leu Glu Asn Met Thr Lys Tyr 
    530                 535                 540                 


Val Ser Lys Leu Glu Glu Pro Ala Gly Lys Lys Lys Thr Ser Glu Glu 
545                 550                 555                 560 


Val Val Val Val Val Ala Lys Pro Lys Gly Pro Pro Val Gln Lys Lys 
                565                 570                 575     


Lys Pro Lys Val Lys Glu Glu Leu 
            580                 


<210>  10234
<211>  254
<212>  PRT
<213>  Homo Sapiens

<400>  10234

Met Ala Trp Gln Gly Leu Val Leu Ala Ala Cys Leu Leu Met Phe Pro 
1               5                   10                  15      


Ser Thr Thr Ala Asp Cys Leu Ser Arg Cys Ser Leu Cys Ala Val Lys 
            20                  25                  30          


Thr Gln Asp Gly Pro Lys Pro Ile Asn Pro Leu Ile Cys Ser Leu Gln 
        35                  40                  45              


Cys Gln Ala Ala Leu Leu Pro Ser Glu Glu Trp Glu Arg Cys Gln Ser 
    50                  55                  60                  


Phe Leu Ser Phe Phe Thr Pro Ser Thr Leu Gly Leu Asn Asp Lys Glu 
65                  70                  75                  80  


Asp Leu Gly Ser Lys Ser Val Gly Glu Gly Pro Tyr Ser Glu Leu Ala 
                85                  90                  95      


Lys Leu Ser Gly Ser Phe Leu Lys Glu Leu Glu Lys Ser Lys Phe Leu 
            100                 105                 110         


Pro Ser Ile Ser Thr Lys Glu Asn Thr Leu Ser Lys Ser Leu Glu Glu 
        115                 120                 125             


Lys Leu Arg Gly Leu Ser Asp Gly Phe Arg Glu Gly Ala Glu Ser Glu 
    130                 135                 140                 


Leu Met Arg Asp Ala Gln Leu Asn Asp Gly Ala Met Glu Thr Gly Thr 
145                 150                 155                 160 


Leu Tyr Leu Ala Glu Glu Asp Pro Lys Glu Gln Val Lys Arg Tyr Gly 
                165                 170                 175     


Gly Phe Leu Arg Lys Tyr Pro Lys Arg Ser Ser Glu Val Ala Gly Glu 
            180                 185                 190         


Gly Asp Gly Asp Ser Met Gly His Glu Asp Leu Tyr Lys Arg Tyr Gly 
        195                 200                 205             


Gly Phe Leu Arg Arg Ile Arg Pro Lys Leu Lys Trp Asp Asn Gln Lys 
    210                 215                 220                 


Arg Tyr Gly Gly Phe Leu Arg Arg Gln Phe Lys Val Val Thr Arg Ser 
225                 230                 235                 240 


Gln Glu Asp Pro Asn Ala Tyr Ser Gly Glu Leu Phe Asp Ala 
                245                 250                 


<210>  10235
<211>  254
<212>  PRT
<213>  Homo Sapiens

<400>  10235

Met Ala Trp Gln Gly Leu Val Leu Ala Ala Cys Leu Leu Met Phe Pro 
1               5                   10                  15      


Ser Thr Thr Ala Asp Cys Leu Ser Arg Cys Ser Leu Cys Ala Val Lys 
            20                  25                  30          


Thr Gln Asp Gly Pro Lys Pro Ile Asn Pro Leu Ile Cys Ser Leu Gln 
        35                  40                  45              


Cys Gln Ala Ala Leu Leu Pro Ser Glu Glu Trp Glu Arg Cys Gln Ser 
    50                  55                  60                  


Phe Leu Ser Phe Phe Thr Pro Ser Thr Leu Gly Leu Asn Asp Lys Glu 
65                  70                  75                  80  


Asp Leu Gly Ser Lys Ser Val Gly Glu Gly Pro Tyr Ser Glu Leu Ala 
                85                  90                  95      


Lys Leu Ser Gly Ser Phe Leu Lys Glu Leu Glu Lys Ser Lys Phe Leu 
            100                 105                 110         


Pro Ser Ile Ser Thr Lys Glu Asn Thr Leu Ser Lys Ser Leu Glu Glu 
        115                 120                 125             


Lys Leu Arg Gly Leu Ser Asp Gly Phe Arg Glu Gly Ala Glu Ser Glu 
    130                 135                 140                 


Leu Met Arg Asp Ala Gln Leu Asn Asp Gly Ala Met Glu Thr Gly Thr 
145                 150                 155                 160 


Leu Tyr Leu Ala Glu Glu Asp Pro Lys Glu Gln Val Lys Arg Tyr Gly 
                165                 170                 175     


Gly Phe Leu Arg Lys Tyr Pro Lys Arg Ser Ser Glu Val Ala Gly Glu 
            180                 185                 190         


Gly Asp Gly Asp Ser Met Gly His Glu Asp Leu Tyr Lys Arg Tyr Gly 
        195                 200                 205             


Gly Phe Leu Arg Arg Ile Arg Pro Lys Leu Lys Trp Asp Asn Gln Lys 
    210                 215                 220                 


Arg Tyr Gly Gly Phe Leu Arg Arg Gln Phe Lys Val Val Thr Arg Ser 
225                 230                 235                 240 


Gln Glu Asp Pro Asn Ala Tyr Ser Gly Glu Leu Phe Asp Ala 
                245                 250                 


<210>  10236
<211>  254
<212>  PRT
<213>  Homo Sapiens

<400>  10236

Met Ala Trp Gln Gly Leu Val Leu Ala Ala Cys Leu Leu Met Phe Pro 
1               5                   10                  15      


Ser Thr Thr Ala Asp Cys Leu Ser Arg Cys Ser Leu Cys Ala Val Lys 
            20                  25                  30          


Thr Gln Asp Gly Pro Lys Pro Ile Asn Pro Leu Ile Cys Ser Leu Gln 
        35                  40                  45              


Cys Gln Ala Ala Leu Leu Pro Ser Glu Glu Trp Glu Arg Cys Gln Ser 
    50                  55                  60                  


Phe Leu Ser Phe Phe Thr Pro Ser Thr Leu Gly Leu Asn Asp Lys Glu 
65                  70                  75                  80  


Asp Leu Gly Ser Lys Ser Val Gly Glu Gly Pro Tyr Ser Glu Leu Ala 
                85                  90                  95      


Lys Leu Ser Gly Ser Phe Leu Lys Glu Leu Glu Lys Ser Lys Phe Leu 
            100                 105                 110         


Pro Ser Ile Ser Thr Lys Glu Asn Thr Leu Ser Lys Ser Leu Glu Glu 
        115                 120                 125             


Lys Leu Arg Gly Leu Ser Asp Gly Phe Arg Glu Gly Ala Glu Ser Glu 
    130                 135                 140                 


Leu Met Arg Asp Ala Gln Leu Asn Asp Gly Ala Met Glu Thr Gly Thr 
145                 150                 155                 160 


Leu Tyr Leu Ala Glu Glu Asp Pro Lys Glu Gln Val Lys Arg Tyr Gly 
                165                 170                 175     


Gly Phe Leu Arg Lys Tyr Pro Lys Arg Ser Ser Glu Val Ala Gly Glu 
            180                 185                 190         


Gly Asp Gly Asp Ser Met Gly His Glu Asp Leu Tyr Lys Arg Tyr Gly 
        195                 200                 205             


Gly Phe Leu Arg Arg Ile Arg Pro Lys Leu Lys Trp Asp Asn Gln Lys 
    210                 215                 220                 


Arg Tyr Gly Gly Phe Leu Arg Arg Gln Phe Lys Val Val Thr Arg Ser 
225                 230                 235                 240 


Gln Glu Asp Pro Asn Ala Tyr Ser Gly Glu Leu Phe Asp Ala 
                245                 250                 


<210>  10237
<211>  1154
<212>  PRT
<213>  Homo Sapiens

<400>  10237

Met Gly Leu Leu Leu Met Ile Leu Ala Ser Ala Val Leu Gly Ser Phe 
1               5                   10                  15      


Leu Thr Leu Leu Ala Gln Phe Phe Leu Leu Tyr Arg Arg Gln Pro Glu 
            20                  25                  30          


Pro Pro Ala Asp Glu Ala Ala Arg Ala Gly Glu Gly Phe Arg Tyr Ile 
        35                  40                  45              


Lys Pro Val Pro Gly Leu Leu Leu Arg Glu Tyr Leu Tyr Gly Gly Gly 
    50                  55                  60                  


Arg Asp Glu Glu Pro Ser Gly Ala Ala Pro Glu Gly Gly Ala Thr Pro 
65                  70                  75                  80  


Thr Ala Ala Pro Glu Thr Pro Ala Pro Pro Thr Arg Glu Thr Cys Tyr 
                85                  90                  95      


Phe Leu Asn Ala Thr Ile Leu Phe Leu Phe Arg Glu Leu Arg Asp Thr 
            100                 105                 110         


Ala Leu Thr Arg Arg Trp Val Thr Lys Lys Ile Lys Val Glu Phe Glu 
        115                 120                 125             


Glu Leu Leu Gln Thr Lys Thr Ala Gly Arg Leu Leu Glu Gly Leu Ser 
    130                 135                 140                 


Leu Arg Asp Val Phe Leu Gly Glu Thr Val Pro Phe Ile Lys Thr Ile 
145                 150                 155                 160 


Arg Leu Val Arg Pro Val Val Pro Ser Ala Thr Gly Glu Pro Asp Gly 
                165                 170                 175     


Pro Glu Gly Glu Ala Leu Pro Ala Ala Cys Pro Glu Glu Leu Ala Phe 
            180                 185                 190         


Glu Ala Glu Val Glu Tyr Asn Gly Gly Phe His Leu Ala Ile Asp Val 
        195                 200                 205             


Asp Leu Val Phe Gly Lys Ser Ala Tyr Leu Phe Val Lys Leu Ser Arg 
    210                 215                 220                 


Val Val Gly Arg Leu Arg Leu Val Phe Thr Arg Val Pro Phe Thr His 
225                 230                 235                 240 


Trp Phe Phe Ser Phe Val Glu Asp Pro Leu Ile Asp Phe Glu Val Arg 
                245                 250                 255     


Ser Gln Phe Glu Gly Arg Pro Met Pro Gln Leu Thr Ser Ile Ile Val 
            260                 265                 270         


Asn Gln Leu Lys Lys Ile Ile Lys Arg Lys His Thr Leu Pro Asn Tyr 
        275                 280                 285             


Lys Ile Arg Phe Lys Pro Phe Phe Pro Tyr Gln Thr Leu Gln Gly Phe 
    290                 295                 300                 


Glu Glu Asp Glu Glu His Ile His Ile Gln Gln Trp Ala Leu Thr Glu 
305                 310                 315                 320 


Gly Arg Leu Lys Val Thr Leu Leu Glu Cys Ser Arg Leu Leu Ile Phe 
                325                 330                 335     


Gly Ser Tyr Asp Arg Glu Ala Asn Val His Cys Thr Leu Glu Leu Ser 
            340                 345                 350         


Ser Ser Val Trp Glu Glu Lys Gln Arg Ser Ser Ile Lys Thr Val Glu 
        355                 360                 365             


Leu Ile Lys Gly Asn Leu Gln Ser Val Gly Leu Thr Leu Arg Leu Val 
    370                 375                 380                 


Gln Ser Thr Asp Gly Tyr Ala Gly His Val Ile Ile Glu Thr Val Ala 
385                 390                 395                 400 


Pro Asn Ser Pro Ala Ala Ile Ala Asp Leu Gln Arg Gly Asp Arg Leu 
                405                 410                 415     


Ile Ala Ile Gly Gly Val Lys Ile Thr Ser Thr Leu Gln Val Leu Lys 
            420                 425                 430         


Leu Ile Lys Gln Ala Gly Asp Arg Val Leu Val Tyr Tyr Glu Arg Pro 
        435                 440                 445             


Val Gly Gln Ser Asn Gln Gly Ala Val Leu Gln Asp Asn Phe Gly Gln 
    450                 455                 460                 


Leu Glu Glu Asn Phe Leu Ser Ser Ser Cys Gln Ser Gly Tyr Glu Glu 
465                 470                 475                 480 


Glu Ala Ala Gly Leu Thr Val Asp Thr Glu Ser Arg Glu Leu Asp Ser 
                485                 490                 495     


Glu Phe Glu Asp Leu Ala Ser Asp Val Arg Ala Gln Asn Glu Phe Lys 
            500                 505                 510         


Asp Glu Ala Gln Ser Leu Ser His Ser Pro Lys Arg Val Pro Thr Thr 
        515                 520                 525             


Leu Ser Ile Lys Pro Leu Gly Ala Ile Ser Pro Val Leu Asn Arg Lys 
    530                 535                 540                 


Leu Ala Val Gly Ser His Pro Leu Pro Pro Lys Ile Gln Ser Lys Asp 
545                 550                 555                 560 


Gly Asn Lys Pro Pro Pro Leu Lys Thr Ser Glu Ile Thr Asp Pro Ala 
                565                 570                 575     


Gln Val Ser Lys Pro Thr Gln Gly Ser Ala Phe Lys Pro Pro Val Pro 
            580                 585                 590         


Pro Arg Pro Gln Ala Lys Val Pro Leu Pro Ser Ala Asp Ala Pro Asn 
        595                 600                 605             


Gln Ala Glu Pro Asp Val Leu Val Glu Lys Pro Glu Lys Val Val Pro 
    610                 615                 620                 


Pro Pro Leu Val Asp Lys Ser Ala Glu Lys Gln Ala Lys Asn Val Asp 
625                 630                 635                 640 


Ala Ile Asp Asp Ala Ala Ala Pro Lys Gln Phe Leu Ala Lys Gln Glu 
                645                 650                 655     


Val Ala Lys Asp Val Thr Ser Glu Thr Ser Cys Pro Thr Lys Asp Ser 
            660                 665                 670         


Ser Asp Asp Arg Gln Thr Trp Glu Ser Ser Glu Ile Leu Tyr Arg Asn 
        675                 680                 685             


Lys Leu Gly Lys Trp Thr Arg Thr Arg Ala Ser Cys Leu Phe Asp Ile 
    690                 695                 700                 


Glu Ala Cys His Arg Tyr Leu Asn Ile Ala Leu Trp Cys Arg Asp Pro 
705                 710                 715                 720 


Phe Lys Leu Gly Gly Leu Ile Cys Leu Gly His Val Ser Leu Lys Leu 
                725                 730                 735     


Glu Asp Val Ala Leu Gly Cys Leu Ala Thr Ser Asn Thr Glu Tyr Leu 
            740                 745                 750         


Ser Lys Leu Arg Leu Glu Ala Pro Ser Pro Lys Ala Ile Val Thr Arg 
        755                 760                 765             


Thr Ala Leu Arg Asn Leu Ser Met Gln Lys Gly Phe Asn Asp Lys Phe 
    770                 775                 780                 


Cys Tyr Gly Asp Ile Thr Ile His Phe Lys Tyr Leu Lys Glu Gly Glu 
785                 790                 795                 800 


Ser Asp His His Val Val Thr Asn Val Glu Lys Glu Lys Glu Pro His 
                805                 810                 815     


Leu Val Glu Glu Val Ser Val Leu Pro Lys Glu Glu Gln Phe Val Gly 
            820                 825                 830         


Gln Met Gly Leu Thr Glu Asn Lys His Ser Phe Gln Asp Thr Gln Phe 
        835                 840                 845             


Gln Asn Pro Thr Trp Cys Asp Tyr Cys Lys Lys Lys Val Trp Thr Lys 
    850                 855                 860                 


Ala Ala Ser Gln Cys Met Phe Cys Ala Tyr Val Cys His Lys Lys Cys 
865                 870                 875                 880 


Gln Glu Lys Cys Leu Ala Glu Thr Ser Val Cys Gly Ala Thr Asp Arg 
                885                 890                 895     


Arg Ile Asp Arg Thr Leu Lys Asn Leu Arg Leu Glu Gly Gln Glu Thr 
            900                 905                 910         


Leu Leu Gly Leu Pro Pro Arg Val Asp Ala Glu Ala Ser Lys Ser Val 
        915                 920                 925             


Asn Lys Thr Thr Gly Leu Thr Arg His Ile Ile Asn Thr Ser Ser Arg 
    930                 935                 940                 


Leu Leu Asn Leu Arg Gln Val Ser Lys Thr Arg Leu Ser Glu Pro Gly 
945                 950                 955                 960 


Thr Asp Leu Val Glu Pro Ser Pro Lys His Thr Pro Asn Thr Ser Asp 
                965                 970                 975     


Asn Glu Gly Ser Asp Thr Glu Val Cys Gly Pro Asn Ser Pro Ser Lys 
            980                 985                 990         


Arg Gly Asn Ser Thr Gly Ile Lys  Leu Val Arg Lys Glu  Gly Gly Leu 
        995                 1000                 1005             


Asp Asp  Ser Val Phe Ile Ala  Val Lys Glu Ile Gly  Arg Asp Leu 
    1010                 1015                 1020             


Tyr Arg  Gly Leu Pro Thr Glu  Glu Arg Ile Gln Lys  Leu Glu Phe 
    1025                 1030                 1035             


Met Leu  Asp Lys Leu Gln Asn  Glu Ile Asp Gln Glu  Leu Glu His 
    1040                 1045                 1050             


Asn Asn  Ser Leu Val Arg Glu  Glu Lys Glu Thr Thr  Asp Thr Arg 
    1055                 1060                 1065             


Lys Lys  Ser Leu Leu Ser Ala  Ala Leu Ala Lys Ser  Gly Glu Arg 
    1070                 1075                 1080             


Leu Gln  Ala Leu Thr Leu Leu  Met Ile His Tyr Arg  Ala Gly Ile 
    1085                 1090                 1095             


Glu Asp  Ile Glu Thr Leu Glu  Ser Leu Ser Leu Asp  Gln His Ser 
    1100                 1105                 1110             


Lys Lys  Ile Ser Lys Tyr Thr  Asp Asp Thr Glu Glu  Asp Leu Asp 
    1115                 1120                 1125             


Asn Glu  Ile Ser Gln Leu Ile  Asp Ser Gln Pro Phe  Ser Ser Ile 
    1130                 1135                 1140             


Ser Asp  Asp Leu Phe Gly Pro  Ser Glu Ser Val 
    1145                 1150                 


<210>  10238
<211>  778
<212>  PRT
<213>  Homo Sapiens

<400>  10238

Met Gly Cys Asn Leu Cys Thr Phe Gln Lys Arg Glu Glu His Tyr Lys 
1               5                   10                  15      


Leu Leu Tyr Glu Val Ser Gln Val Asn Gly Lys Asp Leu Ser Lys Ala 
            20                  25                  30          


Thr His Glu Glu Ala Val Glu Ala Phe Arg Asn Ala Lys Glu Pro Ile 
        35                  40                  45              


Val Val Gln Val Leu Arg Arg Thr Pro Leu Ser Arg Pro Ala Tyr Gly 
    50                  55                  60                  


Met Ala Ser Glu Val Gln Leu Met Asn Ala Ser Thr Gln Thr Asp Ile 
65                  70                  75                  80  


Thr Phe Glu His Ile Met Ala Leu Ala Lys Leu Arg Pro Pro Thr Pro 
                85                  90                  95      


Pro Val Pro Asp Ile Cys Pro Phe Leu Leu Ser Asp Ser Cys His Ser 
            100                 105                 110         


Leu His Pro Met Glu His Glu Phe Tyr Glu Asp Asn Glu Tyr Ile Ser 
        115                 120                 125             


Ser Leu Pro Ala Asp Ala Asp Arg Thr Glu Asp Phe Glu Tyr Glu Glu 
    130                 135                 140                 


Val Glu Leu Cys Arg Val Ser Ser Gln Glu Lys Leu Gly Leu Thr Val 
145                 150                 155                 160 


Cys Tyr Arg Thr Asp Asp Glu Glu Asp Thr Gly Ile Tyr Val Ser Glu 
                165                 170                 175     


Val Asp Pro Asn Ser Ile Ala Ala Lys Asp Gly Arg Ile Arg Glu Gly 
            180                 185                 190         


Asp Arg Ile Leu Gln Ile Asn Gly Glu Asp Val Gln Asn Arg Glu Glu 
        195                 200                 205             


Ala Val Ala Leu Leu Ser Asn Asp Glu Cys Lys Arg Ile Val Leu Leu 
    210                 215                 220                 


Val Ala Arg Pro Glu Ile Gln Leu Asp Glu Gly Trp Leu Glu Asp Glu 
225                 230                 235                 240 


Arg Asn Glu Phe Leu Glu Glu Leu Asn Leu Glu Met Leu Glu Glu Glu 
                245                 250                 255     


His Asn Glu Ala Met Gln Pro Thr Ala Asn Glu Val Glu Gln Pro Lys 
            260                 265                 270         


Lys Gln Glu Glu Glu Glu Gly Thr Thr Asp Thr Ala Thr Ser Ser Ser 
        275                 280                 285             


Asn Asn His Glu Lys Asp Ser Gly Val Gly Arg Thr Asp Glu Ser Leu 
    290                 295                 300                 


Arg Asn Asp Glu Ser Ser Glu Gln Glu Asn Ala Ala Glu Asp Pro Asn 
305                 310                 315                 320 


Ser Thr Ser Leu Lys Ser Lys Arg Asp Leu Gly Gln Ser Gln Asp Thr 
                325                 330                 335     


Leu Gly Ser Val Glu Leu Gln Tyr Asn Glu Ser Leu Val Ser Gly Glu 
            340                 345                 350         


Tyr Ile Asp Ser Asp Cys Ile Gly Asn Pro Asp Glu Asp Cys Glu Arg 
        355                 360                 365             


Phe Arg Gln Leu Leu Glu Leu Lys Cys Lys Ile Arg Asn His Gly Glu 
    370                 375                 380                 


Tyr Asp Leu Tyr Tyr Ser Ser Ser Thr Ile Glu Cys Asn Gln Gly Glu 
385                 390                 395                 400 


Gln Glu Gly Val Glu His Glu Leu Gln Leu Leu Asn Glu Glu Leu Arg 
                405                 410                 415     


Asn Ile Glu Leu Glu Cys Gln Asn Ile Met Gln Ala His Arg Leu Gln 
            420                 425                 430         


Lys Val Thr Asp Gln Tyr Gly Asp Ile Trp Thr Leu His Asp Gly Gly 
        435                 440                 445             


Phe Arg Asn Tyr Asn Thr Ser Ile Asp Met Gln Arg Gly Lys Leu Asp 
    450                 455                 460                 


Asp Ile Met Glu His Pro Glu Lys Ser Asp Lys Asp Ser Ser Ser Ala 
465                 470                 475                 480 


Tyr Asn Thr Ala Glu Ser Cys Arg Ser Thr Pro Leu Thr Val Asp Arg 
                485                 490                 495     


Ser Pro Asp Ser Ser Leu Pro Arg Val Ile Asn Leu Thr Asn Lys Lys 
            500                 505                 510         


Asn Leu Arg Ser Thr Met Ala Ala Thr Gln Ser Ser Ser Gly Gln Ser 
        515                 520                 525             


Ser Lys Glu Ser Thr Ser Thr Lys Ala Lys Thr Thr Glu Gln Gly Cys 
    530                 535                 540                 


Ser Ala Glu Ser Lys Glu Lys Val Leu Glu Gly Ser Lys Leu Pro Asp 
545                 550                 555                 560 


Gln Glu Lys Ala Val Ser Glu His Ile Pro Tyr Leu Ser Pro Tyr His 
                565                 570                 575     


Ser Ser Ser Tyr Arg Tyr Ala Asn Ile Pro Ala His Ala Arg His Tyr 
            580                 585                 590         


Gln Ser Tyr Met Gln Leu Ile Gln Gln Lys Ser Ala Val Glu Tyr Ala 
        595                 600                 605             


Gln Ser Gln Leu Ser Leu Val Ser Met Cys Lys Glu Ser Gln Lys Cys 
    610                 615                 620                 


Ser Glu Pro Lys Met Glu Trp Lys Val Lys Ile Arg Ser Asp Gly Thr 
625                 630                 635                 640 


Arg Tyr Ile Thr Lys Arg Pro Val Arg Asp Arg Ile Leu Lys Glu Arg 
                645                 650                 655     


Ala Leu Lys Ile Lys Glu Glu Arg Ser Gly Met Thr Thr Asp Asp Asp 
            660                 665                 670         


Thr Met Ser Glu Met Lys Met Gly Arg Tyr Trp Ser Lys Glu Glu Arg 
        675                 680                 685             


Lys Gln His Leu Val Arg Ala Lys Glu Gln Arg Arg Arg Arg Glu Phe 
    690                 695                 700                 


Met Met Arg Ser Arg Leu Glu Cys Leu Lys Glu Ser Pro Gln Ser Gly 
705                 710                 715                 720 


Ser Glu Gly Lys Lys Glu Ile Asn Ile Ile Glu Leu Ser His Lys Lys 
                725                 730                 735     


Met Met Lys Lys Arg Asn Lys Lys Ile Leu Asp Asn Trp Met Thr Ile 
            740                 745                 750         


Gln Glu Leu Met Thr His Gly Ala Lys Ser Pro Asp Gly Thr Arg Val 
        755                 760                 765             


His Asn Ala Phe Leu Ser Val Thr Thr Val 
    770                 775             


<210>  10239
<211>  1036
<212>  PRT
<213>  Homo Sapiens

<400>  10239

Met Gly Phe Ala Leu Glu Arg Phe Ala Glu Ala Val Asp Pro Ala Leu 
1               5                   10                  15      


Glu Cys Lys Leu Cys Gly Gln Val Leu Glu Glu Pro Leu Cys Thr Pro 
            20                  25                  30          


Cys Gly His Val Phe Cys Ala Ser Cys Leu Leu Pro Trp Ala Val Arg 
        35                  40                  45              


Arg Arg Arg Cys Pro Leu Gln Cys Gln Pro Leu Ala Pro Gly Glu Leu 
    50                  55                  60                  


Tyr Arg Val Leu Pro Leu Arg Ser Leu Ile Gln Lys Leu Arg Val Gln 
65                  70                  75                  80  


Cys Asp Tyr Arg Ala Arg Gly Cys Gly His Ser Val Arg Leu His Glu 
                85                  90                  95      


Leu Glu Ala His Val Glu His Cys Asp Phe Gly Pro Ala Arg Arg Leu 
            100                 105                 110         


Arg Ser Arg Gly Gly Cys Ala Ser Gly Leu Gly Gly Gly Glu Val Pro 
        115                 120                 125             


Ala Arg Gly Gly Cys Gly Pro Thr Pro Arg Ala Gly Arg Gly Gly Gly 
    130                 135                 140                 


Ala Arg Gly Gly Pro Pro Gly Gly Arg Trp Gly Arg Gly Arg Gly Pro 
145                 150                 155                 160 


Gly Pro Arg Val Leu Ala Trp Arg Arg Arg Glu Lys Ala Leu Leu Ala 
                165                 170                 175     


Gln Leu Trp Ala Leu Gln Gly Glu Val Gln Leu Thr Ala Arg Arg Tyr 
            180                 185                 190         


Gln Glu Lys Phe Thr Gln Tyr Met Ala His Val Arg Asn Phe Val Gly 
        195                 200                 205             


Asp Leu Gly Gly Gly His Arg Arg Asp Gly Glu His Lys Pro Phe Thr 
    210                 215                 220                 


Ile Val Leu Glu Arg Glu Asn Asp Thr Leu Gly Phe Asn Ile Ile Gly 
225                 230                 235                 240 


Gly Arg Pro Asn Gln Asn Asn Gln Glu Gly Thr Ser Thr Glu Gly Ile 
                245                 250                 255     


Tyr Val Ser Lys Ile Leu Glu Asn Gly Pro Ala Asp Arg Ala Asp Gly 
            260                 265                 270         


Leu Glu Ile His Asp Lys Ile Met Glu Val Asn Gly Lys Asp Leu Ser 
        275                 280                 285             


Lys Ala Thr His Glu Glu Ala Val Glu Ala Phe Arg Asn Ala Lys Glu 
    290                 295                 300                 


Pro Ile Val Val Gln Val Leu Arg Arg Thr Pro Leu Ser Arg Pro Ala 
305                 310                 315                 320 


Tyr Gly Met Ala Ser Glu Val Gln Leu Met Asn Ala Ser Thr Gln Thr 
                325                 330                 335     


Asp Ile Thr Phe Glu His Ile Met Ala Leu Ala Lys Leu Arg Pro Pro 
            340                 345                 350         


Thr Pro Pro Val Pro Asp Ile Cys Pro Phe Leu Leu Ser Asp Ser Cys 
        355                 360                 365             


His Ser Leu His Pro Met Glu His Glu Phe Tyr Glu Asp Asn Glu Tyr 
    370                 375                 380                 


Ile Ser Ser Leu Pro Ala Asp Ala Asp Arg Thr Glu Asp Phe Glu Tyr 
385                 390                 395                 400 


Glu Glu Val Glu Leu Cys Arg Val Ser Ser Gln Glu Lys Leu Gly Leu 
                405                 410                 415     


Thr Val Cys Tyr Arg Thr Asp Asp Glu Glu Asp Thr Gly Ile Tyr Val 
            420                 425                 430         


Ser Glu Val Asp Pro Asn Ser Ile Ala Ala Lys Asp Gly Arg Ile Arg 
        435                 440                 445             


Glu Gly Asp Arg Ile Leu Gln Ile Asn Gly Glu Asp Val Gln Asn Arg 
    450                 455                 460                 


Glu Glu Ala Val Ala Leu Leu Ser Asn Asp Glu Cys Lys Arg Ile Val 
465                 470                 475                 480 


Leu Leu Val Ala Arg Pro Glu Ile Gln Leu Asp Glu Gly Trp Leu Glu 
                485                 490                 495     


Asp Glu Arg Asn Glu Phe Leu Glu Glu Leu Asn Leu Glu Met Leu Glu 
            500                 505                 510         


Glu Glu His Asn Glu Ala Met Gln Pro Thr Ala Asn Glu Val Glu Gln 
        515                 520                 525             


Pro Lys Lys Gln Glu Glu Glu Glu Gly Thr Thr Asp Thr Ala Thr Ser 
    530                 535                 540                 


Ser Ser Asn Asn His Glu Lys Asp Ser Gly Val Gly Arg Thr Asp Glu 
545                 550                 555                 560 


Ser Leu Arg Asn Asp Glu Ser Ser Glu Gln Glu Asn Ala Ala Glu Asp 
                565                 570                 575     


Pro Asn Ser Thr Ser Leu Lys Ser Lys Arg Asp Leu Gly Gln Ser Gln 
            580                 585                 590         


Asp Thr Leu Gly Ser Val Glu Leu Gln Tyr Asn Glu Ser Leu Val Ser 
        595                 600                 605             


Gly Glu Tyr Ile Asp Ser Asp Cys Ile Gly Asn Pro Asp Glu Asp Cys 
    610                 615                 620                 


Glu Arg Phe Arg Gln Leu Leu Glu Leu Lys Cys Lys Ile Arg Asn His 
625                 630                 635                 640 


Gly Glu Tyr Asp Leu Tyr Tyr Ser Ser Ser Thr Ile Glu Cys Asn Gln 
                645                 650                 655     


Gly Glu Gln Glu Gly Val Glu His Glu Leu Gln Leu Leu Asn Glu Glu 
            660                 665                 670         


Leu Arg Asn Ile Glu Leu Glu Cys Gln Asn Ile Met Gln Ala His Arg 
        675                 680                 685             


Leu Gln Lys Val Thr Asp Gln Tyr Gly Asp Ile Trp Thr Leu His Asp 
    690                 695                 700                 


Gly Gly Phe Arg Asn Tyr Asn Thr Ser Ile Asp Met Gln Arg Gly Lys 
705                 710                 715                 720 


Leu Asp Asp Ile Met Glu His Pro Glu Lys Ser Asp Lys Asp Ser Ser 
                725                 730                 735     


Ser Ala Tyr Asn Thr Ala Glu Ser Cys Arg Ser Thr Pro Leu Thr Val 
            740                 745                 750         


Asp Arg Ser Pro Asp Ser Ser Leu Pro Arg Val Ile Asn Leu Thr Asn 
        755                 760                 765             


Lys Lys Asn Leu Arg Ser Thr Met Ala Ala Thr Gln Ser Ser Ser Gly 
    770                 775                 780                 


Gln Ser Ser Lys Glu Ser Thr Ser Thr Lys Ala Lys Thr Thr Glu Gln 
785                 790                 795                 800 


Gly Cys Ser Ala Glu Ser Lys Glu Lys Val Leu Glu Gly Ser Lys Leu 
                805                 810                 815     


Pro Asp Gln Glu Lys Ala Val Ser Glu His Ile Pro Tyr Leu Ser Pro 
            820                 825                 830         


Tyr His Ser Ser Ser Tyr Arg Tyr Ala Asn Ile Pro Ala His Ala Arg 
        835                 840                 845             


His Tyr Gln Ser Tyr Met Gln Leu Ile Gln Gln Lys Ser Ala Val Glu 
    850                 855                 860                 


Tyr Ala Gln Ser Gln Leu Ser Leu Val Ser Met Cys Lys Glu Ser Gln 
865                 870                 875                 880 


Lys Cys Ser Glu Pro Lys Met Glu Trp Lys Val Lys Ile Arg Ser Asp 
                885                 890                 895     


Gly Thr Arg Tyr Ile Thr Lys Arg Pro Val Arg Asp Arg Ile Leu Lys 
            900                 905                 910         


Glu Arg Ala Leu Lys Ile Lys Glu Glu Arg Ser Gly Met Thr Thr Asp 
        915                 920                 925             


Asp Asp Thr Met Ser Glu Met Lys Met Gly Arg Tyr Trp Ser Lys Glu 
    930                 935                 940                 


Glu Arg Lys Gln His Leu Val Arg Ala Lys Glu Gln Arg Arg Arg Arg 
945                 950                 955                 960 


Glu Phe Met Met Arg Ser Arg Leu Glu Cys Leu Lys Glu Ser Pro Gln 
                965                 970                 975     


Ser Gly Ser Glu Gly Lys Lys Glu Ile Asn Ile Ile Glu Leu Ser His 
            980                 985                 990         


Lys Lys Met Met Lys Lys Arg Asn  Lys Lys Ile Leu Asp  Asn Trp Met 
        995                 1000                 1005             


Thr Ile  Gln Glu Leu Met Thr  His Gly Ala Lys Ser  Pro Asp Gly 
    1010                 1015                 1020             


Thr Arg  Val His Asn Ala Phe  Leu Ser Val Thr Thr  Val 
    1025                 1030                 1035     


<210>  10240
<211>  776
<212>  PRT
<213>  Homo Sapiens

<400>  10240

Met Ser Gly Lys Arg Gln Phe Phe Leu Lys Pro Leu Ala Leu Leu Thr 
1               5                   10                  15      


Cys Trp Pro Ser Thr Val Asn Gly Lys Asp Leu Ser Lys Ala Thr His 
            20                  25                  30          


Glu Glu Ala Val Glu Ala Phe Arg Asn Ala Lys Glu Pro Ile Val Val 
        35                  40                  45              


Gln Val Leu Arg Arg Thr Pro Leu Ser Arg Pro Ala Tyr Gly Met Ala 
    50                  55                  60                  


Ser Glu Val Gln Leu Met Asn Ala Ser Thr Gln Thr Asp Ile Thr Phe 
65                  70                  75                  80  


Glu His Ile Met Ala Leu Ala Lys Leu Arg Pro Pro Thr Pro Pro Val 
                85                  90                  95      


Pro Asp Ile Cys Pro Phe Leu Leu Ser Asp Ser Cys His Ser Leu His 
            100                 105                 110         


Pro Met Glu His Glu Phe Tyr Glu Asp Asn Glu Tyr Ile Ser Ser Leu 
        115                 120                 125             


Pro Ala Asp Ala Asp Arg Thr Glu Asp Phe Glu Tyr Glu Glu Val Glu 
    130                 135                 140                 


Leu Cys Arg Val Ser Ser Gln Glu Lys Leu Gly Leu Thr Val Cys Tyr 
145                 150                 155                 160 


Arg Thr Asp Asp Glu Glu Asp Thr Gly Ile Tyr Val Ser Glu Val Asp 
                165                 170                 175     


Pro Asn Ser Ile Ala Ala Lys Asp Gly Arg Ile Arg Glu Gly Asp Arg 
            180                 185                 190         


Ile Leu Gln Ile Asn Gly Glu Asp Val Gln Asn Arg Glu Glu Ala Val 
        195                 200                 205             


Ala Leu Leu Ser Asn Asp Glu Cys Lys Arg Ile Val Leu Leu Val Ala 
    210                 215                 220                 


Arg Pro Glu Ile Gln Leu Asp Glu Gly Trp Leu Glu Asp Glu Arg Asn 
225                 230                 235                 240 


Glu Phe Leu Glu Glu Leu Asn Leu Glu Met Leu Glu Glu Glu His Asn 
                245                 250                 255     


Glu Ala Met Gln Pro Thr Ala Asn Glu Val Glu Gln Pro Lys Lys Gln 
            260                 265                 270         


Glu Glu Glu Glu Gly Thr Thr Asp Thr Ala Thr Ser Ser Ser Asn Asn 
        275                 280                 285             


His Glu Lys Asp Ser Gly Val Gly Arg Thr Asp Glu Ser Leu Arg Asn 
    290                 295                 300                 


Asp Glu Ser Ser Glu Gln Glu Asn Ala Ala Glu Asp Pro Asn Ser Thr 
305                 310                 315                 320 


Ser Leu Lys Ser Lys Arg Asp Leu Gly Gln Ser Gln Asp Thr Leu Gly 
                325                 330                 335     


Ser Val Glu Leu Gln Tyr Asn Glu Ser Leu Val Ser Gly Glu Tyr Ile 
            340                 345                 350         


Asp Ser Asp Cys Ile Gly Asn Pro Asp Glu Asp Cys Glu Arg Phe Arg 
        355                 360                 365             


Gln Leu Leu Glu Leu Lys Cys Lys Ile Arg Asn His Gly Glu Tyr Asp 
    370                 375                 380                 


Leu Tyr Tyr Ser Ser Ser Thr Ile Glu Cys Asn Gln Gly Glu Gln Glu 
385                 390                 395                 400 


Gly Val Glu His Glu Leu Gln Leu Leu Asn Glu Glu Leu Arg Asn Ile 
                405                 410                 415     


Glu Leu Glu Cys Gln Asn Ile Met Gln Ala His Arg Leu Gln Lys Val 
            420                 425                 430         


Thr Asp Gln Tyr Gly Asp Ile Trp Thr Leu His Asp Gly Gly Phe Arg 
        435                 440                 445             


Asn Tyr Asn Thr Ser Ile Asp Met Gln Arg Gly Lys Leu Asp Asp Ile 
    450                 455                 460                 


Met Glu His Pro Glu Lys Ser Asp Lys Asp Ser Ser Ser Ala Tyr Asn 
465                 470                 475                 480 


Thr Ala Glu Ser Cys Arg Ser Thr Pro Leu Thr Val Asp Arg Ser Pro 
                485                 490                 495     


Asp Ser Ser Leu Pro Arg Val Ile Asn Leu Thr Asn Lys Lys Asn Leu 
            500                 505                 510         


Arg Ser Thr Met Ala Ala Thr Gln Ser Ser Ser Gly Gln Ser Ser Lys 
        515                 520                 525             


Glu Ser Thr Ser Thr Lys Ala Lys Thr Thr Glu Gln Gly Cys Ser Ala 
    530                 535                 540                 


Glu Ser Lys Glu Lys Val Leu Glu Gly Ser Lys Leu Pro Asp Gln Glu 
545                 550                 555                 560 


Lys Ala Val Ser Glu His Ile Pro Tyr Leu Ser Pro Tyr His Ser Ser 
                565                 570                 575     


Ser Tyr Arg Tyr Ala Asn Ile Pro Ala His Ala Arg His Tyr Gln Ser 
            580                 585                 590         


Tyr Met Gln Leu Ile Gln Gln Lys Ser Ala Val Glu Tyr Ala Gln Ser 
        595                 600                 605             


Gln Leu Ser Leu Val Ser Met Cys Lys Glu Ser Gln Lys Cys Ser Glu 
    610                 615                 620                 


Pro Lys Met Glu Trp Lys Val Lys Ile Arg Ser Asp Gly Thr Arg Tyr 
625                 630                 635                 640 


Ile Thr Lys Arg Pro Val Arg Asp Arg Ile Leu Lys Glu Arg Ala Leu 
                645                 650                 655     


Lys Ile Lys Glu Glu Arg Ser Gly Met Thr Thr Asp Asp Asp Thr Met 
            660                 665                 670         


Ser Glu Met Lys Met Gly Arg Tyr Trp Ser Lys Glu Glu Arg Lys Gln 
        675                 680                 685             


His Leu Val Arg Ala Lys Glu Gln Arg Arg Arg Arg Glu Phe Met Met 
    690                 695                 700                 


Arg Ser Arg Leu Glu Cys Leu Lys Glu Ser Pro Gln Ser Gly Ser Glu 
705                 710                 715                 720 


Gly Lys Lys Glu Ile Asn Ile Ile Glu Leu Ser His Lys Lys Met Met 
                725                 730                 735     


Lys Lys Arg Asn Lys Lys Ile Leu Asp Asn Trp Met Thr Ile Gln Glu 
            740                 745                 750         


Leu Met Thr His Gly Ala Lys Ser Pro Asp Gly Thr Arg Val His Asn 
        755                 760                 765             


Ala Phe Leu Ser Val Thr Thr Val 
    770                 775     


<210>  10241
<211>  77
<212>  PRT
<213>  Homo Sapiens

<400>  10241

Met Ser Pro Pro Leu Cys Pro Leu Leu Leu Leu Ala Val Gly Leu Arg 
1               5                   10                  15      


Leu Ala Gly Thr Leu Asn Pro Ser Asp Pro Asn Thr Cys Ser Phe Trp 
            20                  25                  30          


Glu Ser Phe Thr Thr Thr Thr Lys Glu Ser His Ser Arg Pro Phe Ser 
        35                  40                  45              


Leu Leu Pro Ser Glu Pro Cys Glu Arg Pro Trp Glu Gly Pro His Thr 
    50                  55                  60                  


Cys Pro Gln Pro Thr Asn Ser Glu Glu Thr Pro Gly Phe 
65                  70                  75          


<210>  10242
<211>  173
<212>  PRT
<213>  Homo Sapiens

<400>  10242

Met Ser Pro Pro Leu Cys Pro Leu Leu Leu Leu Ala Val Gly Leu Arg 
1               5                   10                  15      


Leu Ala Gly Thr Leu Asn Pro Ser Asp Pro Asn Thr Cys Ser Phe Trp 
            20                  25                  30          


Glu Ser Phe Thr Thr Thr Thr Lys Glu Ser His Ser Arg Pro Phe Ser 
        35                  40                  45              


Leu Leu Pro Ser Glu Pro Cys Glu Arg Pro Trp Glu Gly Pro His Thr 
    50                  55                  60                  


Cys Pro Gln Pro Thr Val Val Tyr Arg Thr Val Tyr Arg Gln Val Val 
65                  70                  75                  80  


Lys Thr Asp His Arg Gln Arg Leu Gln Cys Cys His Gly Phe Tyr Glu 
                85                  90                  95      


Ser Arg Gly Phe Cys Val Pro Leu Cys Ala Gln Glu Cys Val His Gly 
            100                 105                 110         


Arg Cys Val Ala Pro Asn Gln Cys Gln Cys Val Pro Gly Trp Arg Gly 
        115                 120                 125             


Asp Asp Cys Ser Ser Glu Cys Ala Pro Gly Met Trp Gly Pro Gln Cys 
    130                 135                 140                 


Asp Lys Pro Cys Ser Cys Gly Asn Asn Ser Ser Cys Asp Pro Lys Ser 
145                 150                 155                 160 


Gly Val Cys Ser Cys Pro Ser Gly Leu Gln Pro Pro Asn 
                165                 170             


<210>  10243
<211>  1037
<212>  PRT
<213>  Homo Sapiens

<400>  10243

Met Ser Pro Pro Leu Cys Pro Leu Leu Leu Leu Ala Val Gly Leu Arg 
1               5                   10                  15      


Leu Ala Gly Thr Leu Asn Pro Ser Asp Pro Asn Thr Cys Ser Phe Trp 
            20                  25                  30          


Glu Ser Phe Thr Thr Thr Thr Lys Glu Ser His Ser Arg Pro Phe Ser 
        35                  40                  45              


Leu Leu Pro Ser Glu Pro Cys Glu Arg Pro Trp Glu Gly Pro His Thr 
    50                  55                  60                  


Cys Pro Gln Pro Thr Val Val Tyr Arg Thr Val Tyr Arg Gln Val Val 
65                  70                  75                  80  


Lys Thr Asp His Arg Gln Arg Leu Gln Cys Cys His Gly Phe Tyr Glu 
                85                  90                  95      


Ser Arg Gly Phe Cys Val Pro Leu Cys Ala Gln Glu Cys Val His Gly 
            100                 105                 110         


Arg Cys Val Ala Pro Asn Gln Cys Gln Cys Val Pro Gly Trp Arg Gly 
        115                 120                 125             


Asp Asp Cys Ser Ser Glu Cys Ala Pro Gly Met Trp Gly Pro Gln Cys 
    130                 135                 140                 


Asp Lys Pro Cys Ser Cys Gly Asn Asn Ser Ser Cys Asp Pro Lys Ser 
145                 150                 155                 160 


Gly Val Cys Ser Cys Pro Ser Gly Leu Gln Pro Pro Asn Cys Leu Gln 
                165                 170                 175     


Pro Cys Thr Pro Gly Tyr Tyr Gly Pro Ala Cys Gln Phe Arg Cys Gln 
            180                 185                 190         


Cys His Gly Ala Pro Cys Asp Pro Gln Thr Gly Ala Cys Phe Cys Pro 
        195                 200                 205             


Ala Glu Arg Thr Gly Pro Ser Cys Asp Val Ser Cys Ser Gln Gly Thr 
    210                 215                 220                 


Ser Gly Phe Phe Cys Pro Ser Thr His Ser Cys Gln Asn Gly Gly Val 
225                 230                 235                 240 


Phe Gln Thr Pro Gln Gly Ser Cys Ser Cys Pro Pro Gly Trp Met Gly 
                245                 250                 255     


Thr Ile Cys Ser Leu Pro Cys Pro Glu Gly Phe His Gly Pro Asn Cys 
            260                 265                 270         


Ser Gln Glu Cys Arg Cys His Asn Gly Gly Leu Cys Asp Arg Phe Thr 
        275                 280                 285             


Gly Gln Cys Arg Cys Ala Pro Gly Tyr Thr Gly Asp Arg Cys Arg Glu 
    290                 295                 300                 


Glu Cys Pro Val Gly Arg Phe Gly Gln Asp Cys Ala Glu Thr Cys Asp 
305                 310                 315                 320 


Cys Ala Pro Asp Ala Arg Cys Phe Pro Ala Asn Gly Ala Cys Leu Cys 
                325                 330                 335     


Glu His Gly Phe Thr Gly Asp Arg Cys Thr Asp Arg Leu Cys Pro Asp 
            340                 345                 350         


Gly Phe Tyr Gly Leu Ser Cys Gln Ala Pro Cys Thr Cys Asp Arg Glu 
        355                 360                 365             


His Ser Leu Ser Cys His Pro Met Asn Gly Glu Cys Ser Cys Leu Pro 
    370                 375                 380                 


Gly Trp Ala Gly Leu His Cys Asn Glu Ser Cys Pro Gln Asp Thr His 
385                 390                 395                 400 


Gly Pro Gly Cys Gln Glu His Cys Leu Cys Leu His Gly Gly Val Cys 
                405                 410                 415     


Gln Ala Thr Ser Gly Leu Cys Gln Cys Ala Pro Gly Tyr Thr Gly Pro 
            420                 425                 430         


His Cys Ala Ser Leu Cys Pro Pro Asp Thr Tyr Gly Val Asn Cys Ser 
        435                 440                 445             


Ala Arg Cys Ser Cys Glu Asn Ala Ile Ala Cys Ser Pro Ile Asp Gly 
    450                 455                 460                 


Glu Cys Val Cys Lys Glu Gly Trp Gln Arg Gly Asn Cys Ser Val Pro 
465                 470                 475                 480 


Cys Pro Pro Gly Thr Trp Gly Phe Ser Cys Asn Ala Ser Cys Gln Cys 
                485                 490                 495     


Ala His Glu Ala Val Cys Ser Pro Gln Thr Gly Ala Cys Thr Cys Thr 
            500                 505                 510         


Pro Gly Trp His Gly Ala His Cys Gln Leu Pro Cys Pro Lys Gly Gln 
        515                 520                 525             


Phe Gly Glu Gly Cys Ala Ser Arg Cys Asp Cys Asp His Ser Asp Gly 
    530                 535                 540                 


Cys Asp Pro Val His Gly Arg Cys Gln Cys Gln Ala Gly Trp Met Gly 
545                 550                 555                 560 


Ala Arg Cys His Leu Ser Cys Pro Glu Gly Leu Trp Gly Val Asn Cys 
                565                 570                 575     


Ser Asn Thr Cys Thr Cys Lys Asn Gly Gly Thr Cys Leu Pro Glu Asn 
            580                 585                 590         


Gly Asn Cys Val Cys Ala Pro Gly Phe Arg Gly Pro Ser Cys Gln Arg 
        595                 600                 605             


Ser Cys Gln Pro Gly Arg Tyr Gly Lys Arg Cys Val Pro Cys Lys Cys 
    610                 615                 620                 


Ala Asn His Ser Phe Cys His Pro Ser Asn Gly Thr Cys Tyr Cys Leu 
625                 630                 635                 640 


Ala Gly Trp Thr Gly Pro Asp Cys Ser Gln Pro Cys Pro Pro Gly His 
                645                 650                 655     


Trp Gly Glu Asn Cys Ala Gln Thr Cys Gln Cys His His Gly Gly Thr 
            660                 665                 670         


Cys His Pro Gln Asp Gly Ser Cys Ile Cys Pro Leu Gly Trp Thr Gly 
        675                 680                 685             


His His Cys Leu Glu Gly Cys Pro Leu Gly Thr Phe Gly Ala Asn Cys 
    690                 695                 700                 


Ser Gln Pro Cys Gln Cys Gly Pro Gly Glu Lys Cys His Pro Glu Thr 
705                 710                 715                 720 


Gly Ala Cys Val Cys Pro Pro Gly His Ser Gly Ala Pro Cys Arg Ile 
                725                 730                 735     


Gly Ile Gln Glu Pro Phe Thr Val Met Pro Thr Thr Pro Val Ala Tyr 
            740                 745                 750         


Asn Ser Leu Gly Ala Val Ile Gly Ile Ala Val Leu Gly Ser Leu Val 
        755                 760                 765             


Val Ala Leu Val Ala Leu Phe Ile Gly Tyr Arg His Trp Gln Lys Gly 
    770                 775                 780                 


Lys Glu His His His Leu Ala Val Ala Tyr Ser Ser Gly Arg Leu Asp 
785                 790                 795                 800 


Gly Ser Glu Tyr Val Met Pro Asp Val Pro Pro Ser Tyr Ser His Tyr 
                805                 810                 815     


Tyr Ser Asn Pro Ser Tyr His Thr Leu Ser Gln Cys Ser Pro Asn Pro 
            820                 825                 830         


Pro Pro Pro Asn Lys Val Pro Gly Pro Leu Phe Ala Ser Leu Gln Asn 
        835                 840                 845             


Pro Glu Arg Pro Gly Gly Ala Gln Gly His Asp Asn His Thr Thr Leu 
    850                 855                 860                 


Pro Ala Asp Trp Lys His Arg Arg Glu Pro Pro Pro Gly Pro Leu Asp 
865                 870                 875                 880 


Arg Gly Ser Ser Arg Leu Asp Arg Ser Tyr Ser Tyr Ser Tyr Ser Asn 
                885                 890                 895     


Gly Pro Gly Pro Phe Tyr Asn Lys Gly Leu Ile Ser Glu Glu Glu Leu 
            900                 905                 910         


Gly Ala Ser Val Ala Ser Leu Ser Ser Glu Asn Pro Tyr Ala Thr Ile 
        915                 920                 925             


Arg Asp Leu Pro Ser Leu Pro Gly Gly Pro Arg Glu Ser Ser Tyr Met 
    930                 935                 940                 


Glu Met Lys Gly Pro Pro Ser Gly Ser Pro Pro Arg Gln Pro Pro Gln 
945                 950                 955                 960 


Phe Trp Asp Ser Gln Arg Arg Arg Gln Pro Gln Pro Gln Arg Asp Ser 
                965                 970                 975     


Gly Thr Tyr Glu Gln Pro Ser Pro Leu Ile His Asp Arg Asp Ser Val 
            980                 985                 990         


Gly Ser Gln Pro Pro Leu Pro Pro  Gly Leu Pro Pro Gly  His Tyr Asp 
        995                 1000                 1005             


Ser Pro  Lys Asn Ser His Ile  Pro Gly His Tyr Asp  Leu Pro Pro 
    1010                 1015                 1020             


Val Arg  His Pro Pro Ser Pro  Pro Leu Arg Arg Gln  Asp Arg 
    1025                 1030                 1035         


<210>  10244
<211>  1037
<212>  PRT
<213>  Homo Sapiens

<400>  10244

Met Ser Pro Pro Leu Cys Pro Leu Leu Leu Leu Ala Val Gly Leu Arg 
1               5                   10                  15      


Leu Ala Gly Thr Leu Asn Pro Ser Asp Pro Asn Thr Cys Ser Phe Trp 
            20                  25                  30          


Glu Ser Phe Thr Thr Thr Thr Lys Glu Ser His Ser Arg Pro Phe Ser 
        35                  40                  45              


Leu Leu Pro Ser Glu Pro Cys Glu Arg Pro Trp Glu Gly Pro His Thr 
    50                  55                  60                  


Cys Pro Gln Pro Thr Val Val Tyr Arg Thr Val Tyr Arg Gln Val Val 
65                  70                  75                  80  


Lys Thr Asp His Arg Gln Arg Leu Gln Cys Cys His Gly Phe Tyr Glu 
                85                  90                  95      


Ser Arg Gly Phe Cys Val Pro Leu Cys Ala Gln Glu Cys Val His Gly 
            100                 105                 110         


Arg Cys Val Ala Pro Asn Gln Cys Gln Cys Val Pro Gly Trp Arg Gly 
        115                 120                 125             


Asp Asp Cys Ser Ser Glu Cys Ala Pro Gly Met Trp Gly Pro Gln Cys 
    130                 135                 140                 


Asp Lys Pro Cys Ser Cys Gly Asn Asn Ser Ser Cys Asp Pro Lys Ser 
145                 150                 155                 160 


Gly Val Cys Ser Cys Pro Ser Gly Leu Gln Pro Pro Asn Cys Leu Gln 
                165                 170                 175     


Pro Cys Thr Pro Gly Tyr Tyr Gly Pro Ala Cys Gln Phe Arg Cys Gln 
            180                 185                 190         


Cys His Gly Ala Pro Cys Asp Pro Gln Thr Gly Ala Cys Phe Cys Pro 
        195                 200                 205             


Ala Glu Arg Thr Gly Pro Ser Cys Asp Val Ser Cys Ser Gln Gly Thr 
    210                 215                 220                 


Ser Gly Phe Phe Cys Pro Ser Thr His Ser Cys Gln Asn Gly Gly Val 
225                 230                 235                 240 


Phe Gln Thr Pro Gln Gly Ser Cys Ser Cys Pro Pro Gly Trp Met Gly 
                245                 250                 255     


Thr Ile Cys Ser Leu Pro Cys Pro Glu Gly Phe His Gly Pro Asn Cys 
            260                 265                 270         


Ser Gln Glu Cys Arg Cys His Asn Gly Gly Leu Cys Asp Arg Phe Thr 
        275                 280                 285             


Gly Gln Cys Arg Cys Ala Pro Gly Tyr Thr Gly Asp Arg Cys Arg Glu 
    290                 295                 300                 


Glu Cys Pro Val Gly Arg Phe Gly Gln Asp Cys Ala Glu Thr Cys Asp 
305                 310                 315                 320 


Cys Ala Pro Asp Ala Arg Cys Phe Pro Ala Asn Gly Ala Cys Leu Cys 
                325                 330                 335     


Glu His Gly Phe Thr Gly Asp Arg Cys Thr Asp Arg Leu Cys Pro Asp 
            340                 345                 350         


Gly Phe Tyr Gly Leu Ser Cys Gln Ala Pro Cys Thr Cys Asp Arg Glu 
        355                 360                 365             


His Ser Leu Ser Cys His Pro Met Asn Gly Glu Cys Ser Cys Leu Pro 
    370                 375                 380                 


Gly Trp Ala Gly Leu His Cys Asn Glu Ser Cys Pro Gln Asp Thr His 
385                 390                 395                 400 


Gly Pro Gly Cys Gln Glu His Cys Leu Cys Leu His Gly Gly Val Cys 
                405                 410                 415     


Gln Ala Thr Ser Gly Leu Cys Gln Cys Ala Pro Gly Tyr Thr Gly Pro 
            420                 425                 430         


His Cys Ala Ser Leu Cys Pro Pro Asp Thr Tyr Gly Val Asn Cys Ser 
        435                 440                 445             


Ala Arg Cys Ser Cys Glu Asn Ala Ile Ala Cys Ser Pro Ile Asp Gly 
    450                 455                 460                 


Glu Cys Val Cys Lys Glu Gly Trp Gln Arg Gly Asn Cys Ser Val Pro 
465                 470                 475                 480 


Cys Pro Pro Gly Thr Trp Gly Phe Ser Cys Asn Ala Ser Cys Gln Cys 
                485                 490                 495     


Ala His Glu Ala Val Cys Ser Pro Gln Thr Gly Ala Cys Thr Cys Thr 
            500                 505                 510         


Pro Gly Trp His Gly Ala His Cys Gln Leu Pro Cys Pro Lys Gly Gln 
        515                 520                 525             


Phe Gly Glu Gly Cys Ala Ser Arg Cys Asp Cys Asp His Ser Asp Gly 
    530                 535                 540                 


Cys Asp Pro Val His Gly Arg Cys Gln Cys Gln Ala Gly Trp Met Gly 
545                 550                 555                 560 


Ala Arg Cys His Leu Ser Cys Pro Glu Gly Leu Trp Gly Val Asn Cys 
                565                 570                 575     


Ser Asn Thr Cys Thr Cys Lys Asn Gly Gly Thr Cys Leu Pro Glu Asn 
            580                 585                 590         


Gly Asn Cys Val Cys Ala Pro Gly Phe Arg Gly Pro Ser Cys Gln Arg 
        595                 600                 605             


Ser Cys Gln Pro Gly Arg Tyr Gly Lys Arg Cys Val Pro Cys Lys Cys 
    610                 615                 620                 


Ala Asn His Ser Phe Cys His Pro Ser Asn Gly Thr Cys Tyr Cys Leu 
625                 630                 635                 640 


Ala Gly Trp Thr Gly Pro Asp Cys Ser Gln Pro Cys Pro Pro Gly His 
                645                 650                 655     


Trp Gly Glu Asn Cys Ala Gln Thr Cys Gln Cys His His Gly Gly Thr 
            660                 665                 670         


Cys His Pro Gln Asp Gly Ser Cys Ile Cys Pro Leu Gly Trp Thr Gly 
        675                 680                 685             


His His Cys Leu Glu Gly Cys Pro Leu Gly Thr Phe Gly Ala Asn Cys 
    690                 695                 700                 


Ser Gln Pro Cys Gln Cys Gly Pro Gly Glu Lys Cys His Pro Glu Thr 
705                 710                 715                 720 


Gly Ala Cys Val Cys Pro Pro Gly His Ser Gly Ala Pro Cys Arg Ile 
                725                 730                 735     


Gly Ile Gln Glu Pro Phe Thr Val Met Pro Thr Thr Pro Val Ala Tyr 
            740                 745                 750         


Asn Ser Leu Gly Ala Val Ile Gly Ile Ala Val Leu Gly Ser Leu Val 
        755                 760                 765             


Val Ala Leu Val Ala Leu Phe Ile Gly Tyr Arg His Trp Gln Lys Gly 
    770                 775                 780                 


Lys Glu His His His Leu Ala Val Ala Tyr Ser Ser Gly Arg Leu Asp 
785                 790                 795                 800 


Gly Ser Glu Tyr Val Met Pro Asp Val Pro Pro Ser Tyr Ser His Tyr 
                805                 810                 815     


Tyr Ser Asn Pro Ser Tyr His Thr Leu Ser Gln Cys Ser Pro Asn Pro 
            820                 825                 830         


Pro Pro Pro Asn Lys Val Pro Gly Pro Leu Phe Ala Ser Leu Gln Asn 
        835                 840                 845             


Pro Glu Arg Pro Gly Gly Ala Gln Gly His Asp Asn His Thr Thr Leu 
    850                 855                 860                 


Pro Ala Asp Trp Lys His Arg Arg Glu Pro Pro Pro Gly Pro Leu Asp 
865                 870                 875                 880 


Arg Gly Ser Ser Arg Leu Asp Arg Ser Tyr Ser Tyr Ser Tyr Ser Asn 
                885                 890                 895     


Gly Pro Gly Pro Phe Tyr Asn Lys Gly Leu Ile Ser Glu Glu Glu Leu 
            900                 905                 910         


Gly Ala Ser Val Ala Ser Leu Ser Ser Glu Asn Pro Tyr Ala Thr Ile 
        915                 920                 925             


Arg Asp Leu Pro Ser Leu Pro Gly Gly Pro Arg Glu Ser Ser Tyr Met 
    930                 935                 940                 


Glu Met Lys Gly Pro Pro Ser Gly Ser Pro Pro Arg Gln Pro Pro Gln 
945                 950                 955                 960 


Phe Trp Asp Ser Gln Arg Arg Arg Gln Pro Gln Pro Gln Arg Asp Ser 
                965                 970                 975     


Gly Thr Tyr Glu Gln Pro Ser Pro Leu Ile His Asp Arg Asp Ser Val 
            980                 985                 990         


Gly Ser Gln Pro Pro Leu Pro Pro  Gly Leu Pro Pro Gly  His Tyr Asp 
        995                 1000                 1005             


Ser Pro  Lys Asn Ser His Ile  Pro Gly His Tyr Asp  Leu Pro Pro 
    1010                 1015                 1020             


Val Arg  His Pro Pro Ser Pro  Pro Leu Arg Arg Gln  Asp Arg 
    1025                 1030                 1035         


<210>  10245
<211>  227
<212>  PRT
<213>  Homo Sapiens

<400>  10245

Met Gly Trp Thr Met Arg Leu Val Thr Ala Ala Leu Leu Leu Gly Leu 
1               5                   10                  15      


Met Met Val Val Thr Gly Asp Glu Asp Glu Asn Ser Pro Cys Ala His 
            20                  25                  30          


Glu Ala Leu Leu Asp Glu Asp Thr Leu Phe Cys Gln Gly Leu Glu Val 
        35                  40                  45              


Phe Tyr Pro Glu Leu Gly Asn Ile Gly Cys Lys Val Val Pro Asp Cys 
    50                  55                  60                  


Asn Asn Tyr Arg Gln Lys Ile Thr Ser Trp Met Glu Pro Ile Val Lys 
65                  70                  75                  80  


Phe Pro Gly Ala Val Asp Gly Ala Thr Tyr Ile Leu Val Met Val Asp 
                85                  90                  95      


Pro Asp Ala Pro Ser Arg Ala Glu Pro Arg Gln Arg Phe Trp Arg His 
            100                 105                 110         


Trp Leu Val Thr Asp Ile Lys Gly Ala Asp Leu Lys Lys Gly Lys Ile 
        115                 120                 125             


Gln Gly Gln Glu Leu Ser Ala Tyr Gln Ala Pro Ser Pro Pro Ala His 
    130                 135                 140                 


Ser Gly Phe His Arg Tyr Gln Phe Phe Val Tyr Leu Gln Glu Gly Lys 
145                 150                 155                 160 


Val Ile Ser Leu Leu Pro Lys Glu Asn Lys Thr Arg Gly Ser Trp Lys 
                165                 170                 175     


Met Asp Arg Phe Leu Asn Arg Phe His Leu Gly Glu Pro Glu Ala Ser 
            180                 185                 190         


Thr Gln Phe Met Thr Gln Asn Tyr Gln Asp Ser Pro Thr Leu Gln Ala 
        195                 200                 205             


Pro Arg Glu Arg Ala Ser Glu Pro Lys His Lys Asn Gln Ala Glu Ile 
    210                 215                 220                 


Ala Ala Cys 
225         


<210>  10246
<211>  93
<212>  PRT
<213>  Homo Sapiens

<400>  10246

Met Ser Arg Arg Arg Ala Glu Pro Gly Cys Gly Gly Ser Gly Arg Arg 
1               5                   10                  15      


Ala Gly Ala Pro Gly Glu Gly Arg Gly Arg Arg Arg Tyr Ala Pro Gly 
            20                  25                  30          


Pro Ala Ala Lys Ala Leu Pro Arg Arg Arg Leu Ala Leu Gln Ser Gln 
        35                  40                  45              


Val Pro Met Gly Trp Thr Met Arg Leu Val Thr Ala Ala Leu Leu Leu 
    50                  55                  60                  


Gly Leu Met Met Val Val Thr Gly Asp Glu Asp Glu Asn Ser Pro Cys 
65                  70                  75                  80  


Ala His Glu Ala Leu Leu Asp Glu Asp Thr Leu Phe Cys 
                85                  90              


<210>  10247
<211>  135
<212>  PRT
<213>  Homo Sapiens

<400>  10247

Met Gln Pro Arg Trp Ala Gln Gly Ala Thr Met Trp Leu Gly Val Leu 
1               5                   10                  15      


Leu Thr Leu Leu Leu Cys Ser Ser Leu Glu Gly Gln Glu Asn Ser Phe 
            20                  25                  30          


Thr Ile Asn Ser Val Asp Met Lys Ser Leu Pro Asp Trp Thr Val Gln 
        35                  40                  45              


Asn Gly Lys Asn Leu Thr Leu Gln Cys Phe Ala Asp Val Ser Thr Thr 
    50                  55                  60                  


Ser His Val Lys Pro Gln His Gln Met Leu Phe Tyr Lys Asp Asp Val 
65                  70                  75                  80  


Leu Phe Tyr Asn Ile Ser Ser Met Lys Ser Thr Glu Ser Tyr Phe Ile 
                85                  90                  95      


Pro Glu Val Arg Ile Tyr Asp Ser Gly Thr Tyr Lys Cys Thr Val Ile 
            100                 105                 110         


Val Asn Asn Lys Glu Lys Thr Thr Ala Glu Tyr Gln Val Leu Val Glu 
        115                 120                 125             


Gly Val Pro Ser Pro Arg Val 
    130                 135 


<210>  10248
<211>  230
<212>  PRT
<213>  Homo Sapiens

<400>  10248

Met Gln Pro Arg Trp Ala Gln Gly Ala Thr Met Trp Leu Gly Val Leu 
1               5                   10                  15      


Leu Thr Leu Leu Leu Cys Ser Ser Leu Glu Gly Gln Glu Asn Ser Phe 
            20                  25                  30          


Thr Ile Asn Ser Val Asp Met Lys Ser Leu Pro Asp Trp Thr Val Gln 
        35                  40                  45              


Asn Gly Lys Asn Leu Thr Leu Gln Cys Phe Ala Asp Val Ser Thr Thr 
    50                  55                  60                  


Ser His Val Lys Pro Gln His Gln Met Leu Phe Tyr Lys Asp Asp Val 
65                  70                  75                  80  


Leu Phe Tyr Asn Ile Ser Ser Met Lys Ser Thr Glu Ser Tyr Phe Ile 
                85                  90                  95      


Pro Glu Val Arg Ile Tyr Asp Ser Gly Thr Tyr Lys Cys Thr Val Ile 
            100                 105                 110         


Val Asn Asn Lys Glu Lys Thr Thr Ala Glu Tyr Gln Val Leu Val Glu 
        115                 120                 125             


Gly Val Pro Ser Pro Arg Val Thr Leu Asp Lys Lys Glu Ala Ile Gln 
    130                 135                 140                 


Gly Gly Ile Val Arg Val Asn Cys Ser Val Pro Glu Glu Lys Ala Pro 
145                 150                 155                 160 


Ile His Phe Thr Ile Glu Lys Leu Glu Leu Asn Glu Lys Met Val Lys 
                165                 170                 175     


Leu Lys Arg Glu Lys Asn Ser Arg Asp Gln Asn Phe Val Ile Leu Glu 
            180                 185                 190         


Phe Pro Val Glu Glu Gln Asp Arg Val Leu Ser Phe Arg Cys Gln Ala 
        195                 200                 205             


Arg Ile Ile Ser Gly Ile His Met Gln Thr Ser Glu Ser Thr Lys Ser 
    210                 215                 220                 


Glu Leu Val Thr Val Thr 
225                 230 


<210>  10249
<211>  738
<212>  PRT
<213>  Homo Sapiens

<400>  10249

Met Gln Pro Arg Trp Ala Gln Gly Ala Thr Met Trp Leu Gly Val Leu 
1               5                   10                  15      


Leu Thr Leu Leu Leu Cys Ser Ser Leu Glu Gly Gln Glu Asn Ser Phe 
            20                  25                  30          


Thr Ile Asn Ser Val Asp Met Lys Ser Leu Pro Asp Trp Thr Val Gln 
        35                  40                  45              


Asn Gly Lys Asn Leu Thr Leu Gln Cys Phe Ala Asp Val Ser Thr Thr 
    50                  55                  60                  


Ser His Val Lys Pro Gln His Gln Met Leu Phe Tyr Lys Asp Asp Val 
65                  70                  75                  80  


Leu Phe Tyr Asn Ile Ser Ser Met Lys Ser Thr Glu Ser Tyr Phe Ile 
                85                  90                  95      


Pro Glu Val Arg Ile Tyr Asp Ser Gly Thr Tyr Lys Cys Thr Val Ile 
            100                 105                 110         


Val Asn Asn Lys Glu Lys Thr Thr Ala Glu Tyr Gln Val Leu Val Glu 
        115                 120                 125             


Gly Val Pro Ser Pro Arg Val Thr Leu Asp Lys Lys Glu Ala Ile Gln 
    130                 135                 140                 


Gly Gly Ile Val Arg Val Asn Cys Ser Val Pro Glu Glu Lys Ala Pro 
145                 150                 155                 160 


Ile His Phe Thr Ile Glu Lys Leu Glu Leu Asn Glu Lys Met Val Lys 
                165                 170                 175     


Leu Lys Arg Glu Lys Asn Ser Arg Asp Gln Asn Phe Val Ile Leu Glu 
            180                 185                 190         


Phe Pro Val Glu Glu Gln Asp Arg Val Leu Ser Phe Arg Cys Gln Ala 
        195                 200                 205             


Arg Ile Ile Ser Gly Ile His Met Gln Thr Ser Glu Ser Thr Lys Ser 
    210                 215                 220                 


Glu Leu Val Thr Val Thr Glu Ser Phe Ser Thr Pro Lys Phe His Ile 
225                 230                 235                 240 


Ser Pro Thr Gly Met Ile Met Glu Gly Ala Gln Leu His Ile Lys Cys 
                245                 250                 255     


Thr Ile Gln Val Thr His Leu Ala Gln Glu Phe Pro Glu Ile Ile Ile 
            260                 265                 270         


Gln Lys Asp Lys Ala Ile Val Ala His Asn Arg His Gly Asn Lys Ala 
        275                 280                 285             


Val Tyr Ser Val Met Ala Met Val Glu His Ser Gly Asn Tyr Thr Cys 
    290                 295                 300                 


Lys Val Glu Ser Ser Arg Ile Ser Lys Val Ser Ser Ile Val Val Asn 
305                 310                 315                 320 


Ile Thr Glu Leu Phe Ser Lys Pro Glu Leu Glu Ser Ser Phe Thr His 
                325                 330                 335     


Leu Asp Gln Gly Glu Arg Leu Asn Leu Ser Cys Ser Ile Pro Gly Ala 
            340                 345                 350         


Pro Pro Ala Asn Phe Thr Ile Gln Lys Glu Asp Thr Ile Val Ser Gln 
        355                 360                 365             


Thr Gln Asp Phe Thr Lys Ile Ala Ser Lys Ser Asp Ser Gly Thr Tyr 
    370                 375                 380                 


Ile Cys Thr Ala Gly Ile Asp Lys Val Val Lys Lys Ser Asn Thr Val 
385                 390                 395                 400 


Gln Ile Val Val Cys Glu Met Leu Ser Gln Pro Arg Ile Ser Tyr Asp 
                405                 410                 415     


Ala Gln Phe Glu Val Ile Lys Gly Gln Thr Ile Glu Val Arg Cys Glu 
            420                 425                 430         


Ser Ile Ser Gly Thr Leu Pro Ile Ser Tyr Gln Leu Leu Lys Thr Ser 
        435                 440                 445             


Lys Val Leu Glu Asn Ser Thr Lys Asn Ser Asn Asp Pro Ala Val Phe 
    450                 455                 460                 


Lys Asp Asn Pro Thr Glu Asp Val Glu Tyr Gln Cys Val Ala Asp Asn 
465                 470                 475                 480 


Cys His Ser His Ala Lys Met Leu Ser Glu Val Leu Arg Val Lys Val 
                485                 490                 495     


Ile Ala Pro Val Asp Glu Val Gln Ile Ser Ile Leu Ser Ser Lys Val 
            500                 505                 510         


Val Glu Ser Gly Glu Asp Ile Val Leu Gln Cys Ala Val Asn Glu Gly 
        515                 520                 525             


Ser Gly Pro Ile Thr Tyr Lys Phe Tyr Arg Glu Lys Glu Gly Lys Pro 
    530                 535                 540                 


Phe Tyr Gln Met Thr Ser Asn Ala Thr Gln Ala Phe Trp Thr Lys Gln 
545                 550                 555                 560 


Lys Ala Ser Lys Glu Gln Glu Gly Glu Tyr Tyr Cys Thr Ala Phe Asn 
                565                 570                 575     


Arg Ala Asn His Ala Ser Ser Val Pro Arg Ser Lys Ile Leu Thr Val 
            580                 585                 590         


Arg Val Ile Leu Ala Pro Trp Lys Lys Gly Leu Ile Ala Val Val Ile 
        595                 600                 605             


Ile Gly Val Ile Ile Ala Leu Leu Ile Ile Ala Ala Lys Cys Tyr Phe 
    610                 615                 620                 


Leu Arg Lys Ala Lys Ala Lys Gln Met Pro Val Glu Met Ser Arg Pro 
625                 630                 635                 640 


Ala Val Pro Leu Leu Asn Ser Asn Asn Glu Lys Met Ser Asp Pro Asn 
                645                 650                 655     


Met Glu Ala Asn Ser His Tyr Gly His Asn Asp Asp Val Arg Asn His 
            660                 665                 670         


Ala Met Lys Pro Ile Asn Asp Asn Lys Glu Pro Leu Asn Ser Asp Val 
        675                 680                 685             


Gln Tyr Thr Glu Val Gln Val Ser Ser Ala Glu Ser His Lys Asp Leu 
    690                 695                 700                 


Gly Lys Lys Asp Thr Glu Thr Val Tyr Ser Glu Val Arg Lys Ala Val 
705                 710                 715                 720 


Pro Asp Ala Val Glu Ser Arg Tyr Ser Arg Thr Glu Gly Ser Leu Asp 
                725                 730                 735     


Gly Thr 
        


<210>  10250
<211>  184
<212>  PRT
<213>  Homo Sapiens

<400>  10250

Met Ser Ile Glu Ala Ser Gly Ile Asn Met Phe Leu Met Phe Leu Ala 
1               5                   10                  15      


Gly Ser Ser Leu Glu Gly Gln Glu Asn Ser Phe Thr Ile Asn Ser Val 
            20                  25                  30          


Asp Met Lys Ser Leu Pro Asp Trp Thr Val Gln Asn Gly Lys Asn Leu 
        35                  40                  45              


Thr Leu Gln Cys Phe Ala Asp Val Ser Thr Thr Ser His Val Lys Pro 
    50                  55                  60                  


Gln His Gln Met Leu Phe Tyr Lys Asp Asp Val Leu Phe Tyr Asn Ile 
65                  70                  75                  80  


Ser Ser Met Lys Ser Thr Glu Ser Tyr Phe Ile Pro Glu Val Arg Ile 
                85                  90                  95      


Tyr Asp Ser Gly Thr Tyr Lys Cys Thr Val Ile Val Asn Asn Lys Glu 
            100                 105                 110         


Lys Thr Thr Ala Glu Tyr Gln Val Leu Val Glu Gly Val Pro Ser Pro 
        115                 120                 125             


Arg Val Thr Leu Asp Lys Lys Glu Ala Ile Gln Gly Gly Ile Val Arg 
    130                 135                 140                 


Val Asn Cys Ser Val Pro Glu Glu Lys Ala Pro Ile His Phe Thr Ile 
145                 150                 155                 160 


Glu Lys Leu Glu Leu Asn Glu Lys Met Val Lys Leu Lys Arg Glu Lys 
                165                 170                 175     


Asn Ser Arg Asp Gln Asn Phe Val 
            180                 


<210>  10251
<211>  88
<212>  PRT
<213>  Homo Sapiens

<400>  10251

Phe Leu Thr Leu Cys Thr Trp Leu Leu Leu Leu Gly Pro Gly Leu Leu 
1               5                   10                  15      


Ala Thr Val Arg Ala Glu Cys Ser Gln Asp Cys Ala Thr Cys Ser Tyr 
            20                  25                  30          


Arg Leu Val Arg Pro Ala Asp Ile Asn Phe Leu Lys His Pro Arg Ile 
        35                  40                  45              


Asp Gln Phe Ile His Ser Thr Asn Glu Tyr Leu Met Glu Glu Ala Pro 
    50                  55                  60                  


Asp Gly Gly Lys Ser Gln Cys Asn Ala Ser Lys Trp Arg His Gly Val 
65                  70                  75                  80  


Leu Met Glu Lys Gln Gln Asp Leu 
                85              


<210>  10252
<211>  105
<212>  PRT
<213>  Homo Sapiens

<400>  10252

Met Ala Arg Phe Leu Thr Leu Cys Thr Trp Leu Leu Leu Leu Gly Pro 
1               5                   10                  15      


Gly Leu Leu Ala Thr Val Arg Ala Glu Cys Ser Gln Asp Cys Ala Thr 
            20                  25                  30          


Cys Ser Tyr Arg Leu Val Arg Pro Ala Asp Ile Asn Phe Leu Ala Cys 
        35                  40                  45              


Val Met Glu Cys Glu Gly Lys Leu Pro Ser Leu Lys Ile Trp Glu Thr 
    50                  55                  60                  


Cys Lys Glu Leu Leu Gln Leu Ser Lys Pro Glu Leu Pro Gln Asp Gly 
65                  70                  75                  80  


Thr Ser Thr Leu Arg Glu Asn Ser Lys Pro Glu Glu Ser His Leu Leu 
                85                  90                  95      


Ala Lys Arg Tyr Gly Gly Phe Met Lys 
            100                 105 


<210>  10253
<211>  267
<212>  PRT
<213>  Homo Sapiens

<400>  10253

Met Ala Arg Phe Leu Thr Leu Cys Thr Trp Leu Leu Leu Leu Gly Pro 
1               5                   10                  15      


Gly Leu Leu Ala Thr Val Arg Ala Glu Cys Ser Gln Asp Cys Ala Thr 
            20                  25                  30          


Cys Ser Tyr Arg Leu Val Arg Pro Ala Asp Ile Asn Phe Leu Ala Cys 
        35                  40                  45              


Val Met Glu Cys Glu Gly Lys Leu Pro Ser Leu Lys Ile Trp Glu Thr 
    50                  55                  60                  


Cys Lys Glu Leu Leu Gln Leu Ser Lys Pro Glu Leu Pro Gln Asp Gly 
65                  70                  75                  80  


Thr Ser Thr Leu Arg Glu Asn Ser Lys Pro Glu Glu Ser His Leu Leu 
                85                  90                  95      


Ala Lys Arg Tyr Gly Gly Phe Met Lys Arg Tyr Gly Gly Phe Met Lys 
            100                 105                 110         


Lys Met Asp Glu Leu Tyr Pro Met Glu Pro Glu Glu Glu Ala Asn Gly 
        115                 120                 125             


Ser Glu Ile Leu Ala Lys Arg Tyr Gly Gly Phe Met Lys Lys Asp Ala 
    130                 135                 140                 


Glu Glu Asp Asp Ser Leu Ala Asn Ser Ser Asp Leu Leu Lys Glu Leu 
145                 150                 155                 160 


Leu Glu Thr Gly Asp Asn Arg Glu Arg Ser His His Gln Asp Gly Ser 
                165                 170                 175     


Asp Asn Glu Glu Glu Val Ser Lys Arg Tyr Gly Gly Phe Met Arg Gly 
            180                 185                 190         


Leu Lys Arg Ser Pro Gln Leu Glu Asp Glu Ala Lys Glu Leu Gln Lys 
        195                 200                 205             


Arg Tyr Gly Gly Phe Met Arg Arg Val Gly Arg Pro Glu Trp Trp Met 
    210                 215                 220                 


Asp Tyr Gln Lys Arg Tyr Gly Gly Phe Leu Lys Arg Phe Ala Glu Ala 
225                 230                 235                 240 


Leu Pro Ser Asp Glu Glu Gly Glu Ser Tyr Ser Lys Glu Val Pro Glu 
                245                 250                 255     


Met Glu Lys Arg Tyr Gly Gly Phe Met Arg Phe 
            260                 265         


<210>  10254
<211>  267
<212>  PRT
<213>  Homo Sapiens

<400>  10254

Met Ala Arg Phe Leu Thr Leu Cys Thr Trp Leu Leu Leu Leu Gly Pro 
1               5                   10                  15      


Gly Leu Leu Ala Thr Val Arg Ala Glu Cys Ser Gln Asp Cys Ala Thr 
            20                  25                  30          


Cys Ser Tyr Arg Leu Val Arg Pro Ala Asp Ile Asn Phe Leu Ala Cys 
        35                  40                  45              


Val Met Glu Cys Glu Gly Lys Leu Pro Ser Leu Lys Ile Trp Glu Thr 
    50                  55                  60                  


Cys Lys Glu Leu Leu Gln Leu Ser Lys Pro Glu Leu Pro Gln Asp Gly 
65                  70                  75                  80  


Thr Ser Thr Leu Arg Glu Asn Ser Lys Pro Glu Glu Ser His Leu Leu 
                85                  90                  95      


Ala Lys Arg Tyr Gly Gly Phe Met Lys Arg Tyr Gly Gly Phe Met Lys 
            100                 105                 110         


Lys Met Asp Glu Leu Tyr Pro Met Glu Pro Glu Glu Glu Ala Asn Gly 
        115                 120                 125             


Ser Glu Ile Leu Ala Lys Arg Tyr Gly Gly Phe Met Lys Lys Asp Ala 
    130                 135                 140                 


Glu Glu Asp Asp Ser Leu Ala Asn Ser Ser Asp Leu Leu Lys Glu Leu 
145                 150                 155                 160 


Leu Glu Thr Gly Asp Asn Arg Glu Arg Ser His His Gln Asp Gly Ser 
                165                 170                 175     


Asp Asn Glu Glu Glu Val Ser Lys Arg Tyr Gly Gly Phe Met Arg Gly 
            180                 185                 190         


Leu Lys Arg Ser Pro Gln Leu Glu Asp Glu Ala Lys Glu Leu Gln Lys 
        195                 200                 205             


Arg Tyr Gly Gly Phe Met Arg Arg Val Gly Arg Pro Glu Trp Trp Met 
    210                 215                 220                 


Asp Tyr Gln Lys Arg Tyr Gly Gly Phe Leu Lys Arg Phe Ala Glu Ala 
225                 230                 235                 240 


Leu Pro Ser Asp Glu Glu Gly Glu Ser Tyr Ser Lys Glu Val Pro Glu 
                245                 250                 255     


Met Glu Lys Arg Tyr Gly Gly Phe Met Arg Phe 
            260                 265         


<210>  10255
<211>  79
<212>  PRT
<213>  Homo Sapiens

<400>  10255

Met Ala Arg Phe Leu Thr Leu Cys Thr Trp Leu Leu Leu Leu Gly Pro 
1               5                   10                  15      


Gly Leu Leu Ala Thr Val Arg Ala Glu Cys Ser Gln Asp Cys Ala Thr 
            20                  25                  30          


Cys Ser Tyr Arg Leu Val Arg Pro Ala Asp Ile Asn Phe Leu Asp Cys 
        35                  40                  45              


Gly Gly Gly Glu Glu Glu Gly Cys Ser Phe Gln Asn Phe Pro Tyr Cys 
    50                  55                  60                  


Phe Leu Cys Ser Cys Cys Tyr His Leu Leu Leu Leu Ser Leu Leu 
65                  70                  75                  


<210>  10256
<211>  92
<212>  PRT
<213>  Homo Sapiens

<400>  10256

Met Ala Arg Phe Leu Thr Leu Cys Thr Trp Leu Leu Leu Leu Gly Pro 
1               5                   10                  15      


Gly Leu Leu Ala Thr Val Arg Ala Glu Cys Ser Gln Asp Cys Ala Thr 
            20                  25                  30          


Cys Ser Tyr Arg Leu Val Arg Pro Ala Asp Ile Asn Phe Leu Val Ser 
        35                  40                  45              


Val Ala Arg Gly Glu Cys Cys Ala Pro Cys Glu Thr Glu Phe Pro Gln 
    50                  55                  60                  


Gln Tyr Ala Asp Cys Leu Arg Pro Thr Ala Arg Arg Val Trp Arg Phe 
65                  70                  75                  80  


Ala Pro Gly Arg Ser Arg Ser Gly Ala Ser Pro Trp 
                85                  90          


<210>  10257
<211>  81
<212>  PRT
<213>  Homo Sapiens

<400>  10257

Met Ser Arg Ser Ser Lys Val Val Leu Gly Leu Ser Val Leu Leu Thr 
1               5                   10                  15      


Ala Ala Thr Val Ala Gly Val His Val Lys Gln Gln Trp Asp Gln Gln 
            20                  25                  30          


Arg Leu Arg Asp Gly Val Ile Arg Asp Ile Glu Arg Gln Ile Arg Lys 
        35                  40                  45              


Lys Glu Asn Ile Arg Leu Leu Gly Glu Gln Ile Ile Leu Thr Glu Gln 
    50                  55                  60                  


Leu Glu Ala Glu Arg Glu Lys Met Leu Leu Ala Lys Gly Ser Gln Lys 
65                  70                  75                  80  


Ser 
    


<210>  10258
<211>  101
<212>  PRT
<213>  Homo Sapiens

<400>  10258

Met Ser Ser Ala Ala Gly Phe Cys Ala Ser Arg Pro Gly Leu Leu Phe 
1               5                   10                  15      


Leu Gly Leu Leu Leu Leu Pro Leu Val Val Ala Phe Ala Ser Ala Glu 
            20                  25                  30          


Ala Glu Glu Asp Gly Asp Leu Gln Cys Leu Cys Val Lys Thr Thr Ser 
        35                  40                  45              


Gln Val Arg Pro Arg His Ile Thr Ser Leu Glu Val Ile Lys Ala Gly 
    50                  55                  60                  


Pro His Cys Pro Thr Ala Gln Leu Ile Ala Thr Leu Lys Asn Gly Arg 
65                  70                  75                  80  


Lys Ile Cys Leu Asp Leu Gln Ala Pro Leu Tyr Lys Lys Ile Ile Lys 
                85                  90                  95      


Lys Leu Leu Glu Ser 
            100     


<210>  10259
<211>  104
<212>  PRT
<213>  Homo Sapiens

<400>  10259

Met Ser Ser Ala Ala Arg Ser Arg Leu Thr Arg Ala Thr Arg Gln Glu 
1               5                   10                  15      


Met Leu Phe Leu Ala Leu Leu Leu Leu Pro Val Val Val Ala Phe Ala 
            20                  25                  30          


Arg Ala Glu Ala Glu Glu Asp Gly Asp Leu Gln Cys Leu Cys Val Lys 
        35                  40                  45              


Thr Thr Ser Gln Val Arg Pro Arg His Ile Thr Ser Leu Glu Val Ile 
    50                  55                  60                  


Lys Ala Gly Pro His Cys Pro Thr Ala Gln Leu Ile Ala Thr Leu Lys 
65                  70                  75                  80  


Asn Gly Arg Lys Ile Cys Leu Asp Leu Gln Ala Leu Leu Tyr Lys Lys 
                85                  90                  95      


Ile Ile Lys Glu His Leu Glu Ser 
            100                 


<210>  10260
<211>  776
<212>  PRT
<213>  Homo Sapiens

<400>  10260

Met Cys Gly Tyr Glu Arg Cys Arg Pro Cys Arg Gly Ala His Gly Tyr 
1               5                   10                  15      


Leu Arg Gly Gly Gln Gly Val Leu His Leu Arg Gly Leu Pro Gly His 
            20                  25                  30          


Gly Gly Arg Arg Leu Lys His Arg Arg Gly Arg Leu Gly Glu Cys Leu 
        35                  40                  45              


Gln His Pro Ala Ser Gly Ala Val Arg Gly Asp Trp Arg Glu Lys Pro 
    50                  55                  60                  


Gly Cys Trp Ser His Arg Phe Pro Cys Pro Gly Arg His Ala Leu Val 
65                  70                  75                  80  


Gly Gly Thr Ile Ile Gly Ser Ala Arg Cys Gln Ala Phe Arg Thr Arg 
                85                  90                  95      


Glu Gly Arg Leu Lys Ala Ala Cys Asn Leu Leu Gln Arg Gly Ile Thr 
            100                 105                 110         


Asn Leu Cys Val Ile Gly Gly Asp Gly Ser Leu Thr Gly Ala Asn Leu 
        115                 120                 125             


Phe Arg Lys Glu Trp Ser Gly Leu Leu Glu Glu Leu Ala Arg Asn Gly 
    130                 135                 140                 


Gln Ile Asp Lys Glu Ala Val Gln Lys Tyr Ala Tyr Leu Asn Val Val 
145                 150                 155                 160 


Gly Met Val Gly Ser Ile Asp Asn Asp Phe Cys Gly Thr Asp Met Thr 
                165                 170                 175     


Ile Gly Thr Asp Ser Ala Leu His Arg Ile Ile Glu Val Val Asp Ala 
            180                 185                 190         


Ile Met Thr Thr Ala Gln Ser His Gln Arg Thr Phe Val Leu Glu Val 
        195                 200                 205             


Met Gly Arg His Cys Gly Tyr Leu Ala Leu Val Ser Ala Leu Ala Cys 
    210                 215                 220                 


Gly Ala Asp Trp Val Phe Leu Pro Glu Ser Pro Pro Glu Glu Gly Trp 
225                 230                 235                 240 


Glu Glu Gln Met Cys Val Lys Leu Ser Glu Asn Arg Ala Arg Lys Lys 
                245                 250                 255     


Arg Leu Asn Ile Ile Ile Val Ala Glu Gly Ala Ile Asp Thr Gln Asn 
            260                 265                 270         


Lys Pro Ile Thr Ser Glu Lys Ile Lys Glu Leu Val Val Thr Gln Leu 
        275                 280                 285             


Gly Tyr Asp Thr Arg Val Thr Ile Leu Gly His Val Gln Arg Gly Gly 
    290                 295                 300                 


Thr Pro Ser Ala Phe Asp Arg Ile Leu Ala Ser Arg Met Gly Val Glu 
305                 310                 315                 320 


Ala Val Ile Ala Leu Leu Glu Ala Thr Pro Asp Thr Pro Ala Cys Val 
                325                 330                 335     


Val Ser Leu Asn Gly Asn His Ala Val Arg Leu Pro Leu Met Glu Cys 
            340                 345                 350         


Val Gln Met Thr Gln Asp Val Gln Lys Ala Met Asp Glu Arg Arg Phe 
        355                 360                 365             


Gln Asp Ala Val Arg Leu Arg Gly Arg Ser Phe Ala Gly Asn Leu Asn 
    370                 375                 380                 


Thr Tyr Lys Arg Leu Ala Ile Lys Leu Pro Asp Asp Gln Ile Pro Lys 
385                 390                 395                 400 


Thr Asn Cys Asn Val Ala Val Ile Asn Val Gly Ala Pro Ala Ala Gly 
                405                 410                 415     


Met Asn Ala Ala Val Arg Ser Ala Val Arg Val Gly Ile Ala Asp Gly 
            420                 425                 430         


His Arg Met Leu Ala Ile Tyr Asp Gly Phe Asp Gly Phe Ala Lys Gly 
        435                 440                 445             


Gln Ile Lys Glu Ile Gly Trp Thr Asp Val Gly Gly Trp Thr Gly Gln 
    450                 455                 460                 


Gly Gly Ser Ile Leu Gly Thr Lys Arg Val Leu Pro Gly Lys Tyr Leu 
465                 470                 475                 480 


Glu Glu Ile Ala Thr Gln Met Arg Thr His Ser Ile Asn Ala Leu Leu 
                485                 490                 495     


Ile Ile Gly Gly Phe Glu Ala Tyr Leu Gly Leu Leu Glu Leu Ser Ala 
            500                 505                 510         


Ala Arg Glu Lys His Glu Glu Phe Cys Val Pro Met Val Met Val Pro 
        515                 520                 525             


Ala Thr Val Ser Asn Asn Val Pro Gly Ser Asp Phe Ser Ile Gly Ala 
    530                 535                 540                 


Asp Thr Ala Leu Asn Thr Ile Thr Asp Thr Cys Asp Arg Ile Lys Gln 
545                 550                 555                 560 


Ser Ala Ser Gly Thr Lys Arg Arg Val Phe Ile Ile Glu Thr Met Gly 
                565                 570                 575     


Gly Tyr Cys Gly Tyr Leu Ala Asn Met Gly Gly Leu Ala Ala Gly Ala 
            580                 585                 590         


Asp Ala Ala Tyr Ile Phe Glu Glu Pro Phe Asp Ile Arg Asp Leu Gln 
        595                 600                 605             


Ser Asn Val Glu His Leu Thr Glu Lys Met Lys Thr Thr Ile Gln Arg 
    610                 615                 620                 


Gly Leu Val Leu Arg Asn Glu Ser Cys Ser Glu Asn Tyr Thr Thr Asp 
625                 630                 635                 640 


Phe Ile Tyr Gln Leu Tyr Ser Glu Glu Gly Lys Gly Val Phe Asp Cys 
                645                 650                 655     


Arg Lys Asn Val Leu Gly His Met Gln Gln Gly Gly Ala Pro Ser Pro 
            660                 665                 670         


Phe Asp Arg Asn Phe Gly Thr Lys Ile Ser Ala Arg Ala Met Glu Trp 
        675                 680                 685             


Ile Thr Ala Lys Leu Lys Glu Ala Arg Gly Arg Gly Lys Lys Phe Thr 
    690                 695                 700                 


Thr Asp Asp Ser Ile Cys Val Leu Gly Ile Ser Lys Arg Asn Val Ile 
705                 710                 715                 720 


Phe Gln Pro Val Ala Glu Leu Lys Lys Gln Thr Asp Phe Glu His Arg 
                725                 730                 735     


Ile Pro Lys Glu Gln Trp Trp Leu Lys Leu Arg Pro Leu Met Lys Ile 
            740                 745                 750         


Leu Ala Lys Tyr Lys Ala Ser Tyr Asp Val Ser Asp Ser Gly Gln Leu 
        755                 760                 765             


Glu His Val Gln Pro Trp Ser Val 
    770                 775     


<210>  10261
<211>  784
<212>  PRT
<213>  Homo Sapiens

<400>  10261

Met Asp Ala Asp Asp Ser Arg Ala Pro Lys Gly Ser Leu Arg Lys Phe 
1               5                   10                  15      


Leu Glu His Leu Ser Gly Ala Gly Lys Ala Ile Gly Val Leu Thr Ser 
            20                  25                  30          


Gly Gly Asp Ala Gln Gly Met Asn Ala Ala Val Arg Ala Val Val Arg 
        35                  40                  45              


Met Gly Ile Tyr Val Gly Ala Lys Val Tyr Phe Ile Tyr Glu Gly Tyr 
    50                  55                  60                  


Gln Gly Met Val Asp Gly Gly Ser Asn Ile Ala Glu Ala Asp Trp Glu 
65                  70                  75                  80  


Ser Val Ser Ser Ile Leu Gln Val Gly Gly Thr Ile Ile Gly Ser Ala 
                85                  90                  95      


Arg Cys Gln Ala Phe Arg Thr Arg Glu Gly Arg Leu Lys Ala Ala Cys 
            100                 105                 110         


Asn Leu Leu Gln Arg Gly Ile Thr Asn Leu Cys Val Ile Gly Gly Asp 
        115                 120                 125             


Gly Ser Leu Thr Gly Ala Asn Leu Phe Arg Lys Glu Trp Ser Gly Leu 
    130                 135                 140                 


Leu Glu Glu Leu Ala Arg Asn Gly Gln Ile Asp Lys Glu Ala Val Gln 
145                 150                 155                 160 


Lys Tyr Ala Tyr Leu Asn Val Val Gly Met Val Gly Ser Ile Asp Asn 
                165                 170                 175     


Asp Phe Cys Gly Thr Asp Met Thr Ile Gly Thr Asp Ser Ala Leu His 
            180                 185                 190         


Arg Ile Ile Glu Val Val Asp Ala Ile Met Thr Thr Ala Gln Ser His 
        195                 200                 205             


Gln Arg Thr Phe Val Leu Glu Val Met Gly Arg His Cys Gly Tyr Leu 
    210                 215                 220                 


Ala Leu Val Ser Ala Leu Ala Cys Gly Ala Asp Trp Val Phe Leu Pro 
225                 230                 235                 240 


Glu Ser Pro Pro Glu Glu Gly Trp Glu Glu Gln Met Cys Val Lys Leu 
                245                 250                 255     


Ser Glu Asn Arg Ala Arg Lys Lys Arg Leu Asn Ile Ile Ile Val Ala 
            260                 265                 270         


Glu Gly Ala Ile Asp Thr Gln Asn Lys Pro Ile Thr Ser Glu Lys Ile 
        275                 280                 285             


Lys Glu Leu Val Val Thr Gln Leu Gly Tyr Asp Thr Arg Val Thr Ile 
    290                 295                 300                 


Leu Gly His Val Gln Arg Gly Gly Thr Pro Ser Ala Phe Asp Arg Ile 
305                 310                 315                 320 


Leu Ala Ser Arg Met Gly Val Glu Ala Val Ile Ala Leu Leu Glu Ala 
                325                 330                 335     


Thr Pro Asp Thr Pro Ala Cys Val Val Ser Leu Asn Gly Asn His Ala 
            340                 345                 350         


Val Arg Leu Pro Leu Met Glu Cys Val Gln Met Thr Gln Asp Val Gln 
        355                 360                 365             


Lys Ala Met Asp Glu Arg Arg Phe Gln Asp Ala Val Arg Leu Arg Gly 
    370                 375                 380                 


Arg Ser Phe Ala Gly Asn Leu Asn Thr Tyr Lys Arg Leu Ala Ile Lys 
385                 390                 395                 400 


Leu Pro Asp Asp Gln Ile Pro Lys Thr Asn Cys Asn Val Ala Val Ile 
                405                 410                 415     


Asn Val Gly Ala Pro Ala Ala Gly Met Asn Ala Ala Val Arg Ser Ala 
            420                 425                 430         


Val Arg Val Gly Ile Ala Asp Gly His Arg Met Leu Ala Ile Tyr Asp 
        435                 440                 445             


Gly Phe Asp Gly Phe Ala Lys Gly Gln Ile Lys Glu Ile Gly Trp Thr 
    450                 455                 460                 


Asp Val Gly Gly Trp Thr Gly Gln Gly Gly Ser Ile Leu Gly Thr Lys 
465                 470                 475                 480 


Arg Val Leu Pro Gly Lys Tyr Leu Glu Glu Ile Ala Thr Gln Met Arg 
                485                 490                 495     


Thr His Ser Ile Asn Ala Leu Leu Ile Ile Gly Gly Phe Glu Ala Tyr 
            500                 505                 510         


Leu Gly Leu Leu Glu Leu Ser Ala Ala Arg Glu Lys His Glu Glu Phe 
        515                 520                 525             


Cys Val Pro Met Val Met Val Pro Ala Thr Val Ser Asn Asn Val Pro 
    530                 535                 540                 


Gly Ser Asp Phe Ser Ile Gly Ala Asp Thr Ala Leu Asn Thr Ile Thr 
545                 550                 555                 560 


Asp Thr Cys Asp Arg Ile Lys Gln Ser Ala Ser Gly Thr Lys Arg Arg 
                565                 570                 575     


Val Phe Ile Ile Glu Thr Met Gly Gly Tyr Cys Gly Tyr Leu Ala Asn 
            580                 585                 590         


Met Gly Gly Leu Ala Ala Gly Ala Asp Ala Ala Tyr Ile Phe Glu Glu 
        595                 600                 605             


Pro Phe Asp Ile Arg Asp Leu Gln Ser Asn Val Glu His Leu Thr Glu 
    610                 615                 620                 


Lys Met Lys Thr Thr Ile Gln Arg Gly Leu Val Leu Arg Asn Glu Ser 
625                 630                 635                 640 


Cys Ser Glu Asn Tyr Thr Thr Asp Phe Ile Tyr Gln Leu Tyr Ser Glu 
                645                 650                 655     


Glu Gly Lys Gly Val Phe Asp Cys Arg Lys Asn Val Leu Gly His Met 
            660                 665                 670         


Gln Gln Gly Gly Ala Pro Ser Pro Phe Asp Arg Asn Phe Gly Thr Lys 
        675                 680                 685             


Ile Ser Ala Arg Ala Met Glu Trp Ile Thr Ala Lys Leu Lys Glu Ala 
    690                 695                 700                 


Arg Gly Arg Gly Lys Lys Phe Thr Thr Asp Asp Ser Ile Cys Val Leu 
705                 710                 715                 720 


Gly Ile Ser Lys Arg Asn Val Ile Phe Gln Pro Val Ala Glu Leu Lys 
                725                 730                 735     


Lys Gln Thr Asp Phe Glu His Arg Ile Pro Lys Glu Gln Trp Trp Leu 
            740                 745                 750         


Lys Leu Arg Pro Leu Met Lys Ile Leu Ala Lys Tyr Lys Ala Ser Tyr 
        755                 760                 765             


Asp Val Ser Asp Ser Gly Gln Leu Glu His Val Gln Pro Trp Ser Val 
    770                 775                 780                 


<210>  10262
<211>  202
<212>  PRT
<213>  Homo Sapiens

<400>  10262

Met Gly Gly Tyr Cys Gly Tyr Leu Ala Asn Met Gly Gly Leu Ala Ala 
1               5                   10                  15      


Gly Ala Asp Ala Ala Tyr Ile Phe Glu Glu Pro Phe Asp Ile Arg Asp 
            20                  25                  30          


Leu Gln Ser Asn Val Glu His Leu Thr Glu Lys Met Lys Thr Thr Ile 
        35                  40                  45              


Gln Arg Gly Leu Val Leu Arg Asn Glu Ser Cys Ser Glu Asn Tyr Thr 
    50                  55                  60                  


Thr Asp Phe Ile Tyr Gln Leu Tyr Ser Glu Glu Gly Lys Gly Val Phe 
65                  70                  75                  80  


Asp Cys Arg Lys Asn Val Leu Gly His Met Gln Gln Gly Gly Ala Pro 
                85                  90                  95      


Ser Pro Phe Asp Arg Asn Phe Gly Thr Lys Ile Ser Ala Arg Ala Met 
            100                 105                 110         


Glu Trp Ile Thr Ala Lys Leu Lys Glu Ala Arg Gly Arg Gly Lys Lys 
        115                 120                 125             


Phe Thr Thr Asp Asp Ser Ile Cys Val Leu Gly Ile Ser Lys Arg Asn 
    130                 135                 140                 


Val Ile Phe Gln Pro Val Ala Glu Leu Lys Lys Gln Thr Asp Phe Glu 
145                 150                 155                 160 


His Arg Ile Pro Lys Glu Gln Trp Trp Leu Lys Leu Arg Pro Leu Met 
                165                 170                 175     


Lys Ile Leu Ala Lys Tyr Lys Ala Ser Tyr Asp Val Ser Asp Ser Gly 
            180                 185                 190         


Gln Leu Glu His Val Gln Pro Trp Ser Val 
        195                 200         


<210>  10263
<211>  118
<212>  PRT
<213>  Homo Sapiens

<400>  10263

Met Gly Arg His Cys Gly Tyr Leu Ala Leu Val Ser Ala Leu Ala Cys 
1               5                   10                  15      


Gly Ala Asp Trp Val Phe Leu Pro Glu Ser Pro Pro Glu Glu Gly Trp 
            20                  25                  30          


Glu Glu Gln Met Cys Val Lys Leu Ser Glu Asn Arg Ala Arg Lys Lys 
        35                  40                  45              


Arg Leu Asn Ile Ile Ile Val Ala Glu Gly Ala Ile Asp Thr Gln Asn 
    50                  55                  60                  


Lys Pro Ile Thr Ser Glu Lys Ile Lys Glu Leu Val Val Thr Gln Leu 
65                  70                  75                  80  


Gly Tyr Asp Thr Arg Val Thr Ile Leu Gly His Val Gln Arg Gly Gly 
                85                  90                  95      


Thr Pro Ser Ala Phe Asp Arg Ile Leu Ala Ser Arg Met Gly Val Glu 
            100                 105                 110         


Ala Val Ile Ala Leu Leu 
        115             


<210>  10264
<211>  240
<212>  PRT
<213>  Homo Sapiens

<400>  10264

Met Gly Arg His Cys Gly Tyr Leu Ala Leu Val Ser Ala Leu Ala Cys 
1               5                   10                  15      


Gly Ala Asp Trp Val Phe Leu Pro Glu Ser Pro Pro Glu Glu Gly Trp 
            20                  25                  30          


Glu Glu Gln Met Cys Val Lys Leu Ser Glu Asn Arg Ala Arg Lys Lys 
        35                  40                  45              


Arg Leu Asn Ile Ile Ile Val Ala Glu Gly Ala Ile Asp Thr Gln Asn 
    50                  55                  60                  


Lys Pro Ile Thr Ser Glu Lys Ile Lys Glu Leu Val Val Thr Gln Leu 
65                  70                  75                  80  


Gly Tyr Asp Thr Arg Val Thr Ile Leu Gly His Val Gln Arg Gly Gly 
                85                  90                  95      


Thr Pro Ser Ala Phe Asp Arg Ile Leu Ala Ser Arg Met Gly Val Glu 
            100                 105                 110         


Ala Val Ile Ala Leu Leu Glu Ala Thr Pro Asp Thr Pro Ala Cys Val 
        115                 120                 125             


Val Ser Leu Asn Gly Asn His Ala Val Arg Leu Pro Leu Met Glu Cys 
    130                 135                 140                 


Val Gln Met Thr Gln Asp Val Gln Lys Ala Met Asp Glu Arg Arg Phe 
145                 150                 155                 160 


Gln Asp Ala Val Arg Leu Arg Gly Arg Ser Phe Ala Gly Asn Leu Asn 
                165                 170                 175     


Thr Tyr Lys Arg Leu Ala Ile Lys Leu Pro Asp Asp Gln Ile Pro Lys 
            180                 185                 190         


Thr Asn Cys Asn Val Ala Val Ile Asn Val Gly Ala Pro Ala Ala Gly 
        195                 200                 205             


Met Asn Ala Ala Val Arg Ser Ala Val Arg Val Gly Ile Ala Asp Gly 
    210                 215                 220                 


His Arg Met Leu Ala Ile Tyr Asp Gly Phe Asp Gly Phe Ala Lys Gly 
225                 230                 235                 240 


<210>  10265
<211>  113
<212>  PRT
<213>  Homo Sapiens

<400>  10265

Met Asn Ala Ala Val Arg Ala Val Val Arg Met Gly Ile Tyr Val Gly 
1               5                   10                  15      


Ala Lys Val Tyr Phe Ile Tyr Glu Gly Tyr Gln Gly Met Val Asp Gly 
            20                  25                  30          


Gly Ser Asn Ile Ala Glu Ala Asp Trp Glu Ser Val Ser Ser Ile Leu 
        35                  40                  45              


Gln Val Gly Gly Thr Ile Ile Gly Ser Ala Arg Cys Gln Ala Phe Arg 
    50                  55                  60                  


Thr Arg Glu Gly Arg Leu Lys Ala Ala Cys Asn Leu Leu Gln Arg Gly 
65                  70                  75                  80  


Ile Thr Asn Leu Cys Val Ile Gly Gly Asp Gly Ser Leu Thr Gly Ala 
                85                  90                  95      


Asn Leu Phe Arg Lys Glu Trp Ser Gly Leu Leu Glu Glu Leu Ala Arg 
            100                 105                 110         


Asn 
    


<210>  10266
<211>  210
<212>  PRT
<213>  Homo Sapiens

<400>  10266

Met Asn Ala Ala Val Arg Ala Val Val Arg Met Gly Ile Tyr Val Gly 
1               5                   10                  15      


Ala Lys Val Tyr Phe Ile Tyr Glu Gly Tyr Gln Gly Met Val Asp Gly 
            20                  25                  30          


Gly Ser Asn Ile Ala Glu Ala Asp Trp Glu Ser Val Ser Ser Ile Leu 
        35                  40                  45              


Gln Val Gly Gly Thr Ile Ile Gly Ser Ala Arg Cys Gln Ala Phe Arg 
    50                  55                  60                  


Thr Arg Glu Gly Arg Leu Lys Ala Ala Cys Asn Leu Leu Gln Arg Gly 
65                  70                  75                  80  


Ile Thr Asn Leu Cys Val Ile Gly Gly Asp Gly Ser Leu Thr Gly Ala 
                85                  90                  95      


Asn Leu Phe Arg Lys Glu Trp Ser Gly Leu Leu Glu Glu Leu Ala Arg 
            100                 105                 110         


Asn Gly Gln Ile Asp Lys Glu Ala Val Gln Lys Tyr Ala Tyr Leu Asn 
        115                 120                 125             


Val Val Gly Met Val Gly Ser Ile Asp Asn Asp Phe Cys Gly Thr Asp 
    130                 135                 140                 


Met Thr Ile Gly Thr Asp Ser Ala Leu His Arg Ile Ile Glu Val Val 
145                 150                 155                 160 


Asp Ala Ile Met Thr Thr Ala Gln Ser His Gln Arg Thr Phe Val Leu 
                165                 170                 175     


Glu Val Met Gly Arg His Cys Gly Tyr Leu Ala Leu Val Ser Ala Leu 
            180                 185                 190         


Ala Cys Gly Ala Asp Trp Val Phe Leu Pro Glu Ser Pro Pro Glu Glu 
        195                 200                 205             


Gly Trp 
    210 


<210>  10267
<211>  166
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  10267

Xaa Ala Asp Gly His Arg Met Leu Ala Ile Tyr Asp Gly Phe Asp Gly 
1               5                   10                  15      


Phe Ala Lys Gly Gln Ile Lys Glu Ile Gly Trp Thr Asp Val Gly Gly 
            20                  25                  30          


Trp Thr Gly Gln Gly Gly Ser Ile Leu Gly Thr Lys Arg Val Leu Pro 
        35                  40                  45              


Gly Lys Tyr Leu Glu Glu Ile Ala Thr Gln Met Arg Thr His Ser Ile 
    50                  55                  60                  


Asn Ala Leu Leu Ile Ile Gly Gly Phe Glu Ala Tyr Lys Ser Ala Cys 
65                  70                  75                  80  


Asp Met Ala Glu Ala Arg Gly Arg His Gln Glu Leu Cys Ile Pro Leu 
                85                  90                  95      


Cys Val Val Pro Ala Thr Ile Ser Asn Asn Val Pro Gly Thr Glu Ile 
            100                 105                 110         


Ser Leu Gly Ser Asp Thr Gly Leu Asn Ala Val Val Glu Thr Cys Asp 
        115                 120                 125             


Arg Ile Lys Gln Ser Ala Ser Gly Thr Lys Arg Arg Val Phe Ile Ile 
    130                 135                 140                 


Glu Thr Met Gly Gly Tyr Cys Gly Tyr Leu Ala Asn Met Gly Gly Leu 
145                 150                 155                 160 


Ala Ala Gly Ala Asp Ala 
                165     


<210>  10268
<211>  103
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  10268

Xaa Phe Ile Tyr Gln Leu Tyr Ser Glu Glu Gly Lys Gly Val Phe Asp 
1               5                   10                  15      


Cys Arg Lys Asn Val Leu Gly His Met Gln Gln Gly Gly Ala Pro Ser 
            20                  25                  30          


Pro Phe Asp Arg Asn Phe Gly Thr Lys Ile Ser Ala Arg Ala Met Glu 
        35                  40                  45              


Trp Ile Thr Ala Lys Leu Lys Glu Ala Arg Gly Arg Gly Lys Lys Phe 
    50                  55                  60                  


Thr Thr Asp Asp Ser Ile Cys Val Leu Gly Ile Ser Lys Arg Asn Val 
65                  70                  75                  80  


Ile Phe Gln Pro Val Ala Glu Leu Lys Lys Gln Thr Asp Phe Glu Thr 
                85                  90                  95      


Val Ser Met Gln Pro Pro Arg 
            100             


<210>  10269
<211>  140
<212>  PRT
<213>  Homo Sapiens

<400>  10269

Met Ala Gly Trp Asn Ala Tyr Ile Asp Asn Leu Met Ala Asp Gly Thr 
1               5                   10                  15      


Cys Gln Asp Ala Ala Ile Val Gly Tyr Lys Asp Ser Pro Ser Val Trp 
            20                  25                  30          


Ala Ala Val Pro Gly Lys Thr Phe Val Asn Ile Thr Pro Ala Glu Val 
        35                  40                  45              


Gly Val Leu Val Gly Lys Asp Arg Ser Ser Phe Tyr Val Asn Gly Leu 
    50                  55                  60                  


Thr Leu Gly Gly Gln Lys Cys Ser Val Ile Arg Asp Ser Leu Leu Gln 
65                  70                  75                  80  


Asp Gly Glu Phe Ser Met Asp Leu Arg Thr Lys Ser Thr Gly Gly Ala 
                85                  90                  95      


Pro Thr Phe Asn Val Thr Val Thr Lys Thr Asp Lys Thr Leu Val Leu 
            100                 105                 110         


Leu Met Gly Lys Glu Gly Val His Gly Gly Leu Ile Asn Lys Lys Cys 
        115                 120                 125             


Tyr Glu Met Ala Ser His Leu Arg Arg Ser Gln Tyr 
    130                 135                 140 


<210>  10270
<211>  104
<212>  PRT
<213>  Homo Sapiens

<400>  10270

Met Gly Ala Trp Phe Leu Phe Gln Pro Ala Glu Val Gly Val Leu Val 
1               5                   10                  15      


Gly Lys Asp Arg Ser Ser Phe Tyr Val Asn Gly Leu Thr Leu Gly Gly 
            20                  25                  30          


Gln Lys Cys Ser Val Ile Arg Asp Ser Leu Leu Gln Asp Gly Glu Phe 
        35                  40                  45              


Ser Met Asp Leu Arg Thr Lys Ser Thr Gly Gly Ala Pro Thr Phe Asn 
    50                  55                  60                  


Val Thr Val Thr Lys Thr Asp Lys Thr Leu Val Leu Leu Met Gly Lys 
65                  70                  75                  80  


Glu Gly Val His Gly Gly Leu Ile Asn Lys Lys Cys Tyr Glu Met Ala 
                85                  90                  95      


Ser His Leu Arg Arg Ser Gln Tyr 
            100                 


<210>  10271
<211>  165
<212>  PRT
<213>  Homo Sapiens

<400>  10271

Met His Ser Arg Pro Arg Arg Arg Arg Arg Arg Gly His Thr Arg Arg 
1               5                   10                  15      


Arg Pro Pro Val Leu Pro Phe Gly Gly Gly Ser Gly Gly Ala Arg Ala 
            20                  25                  30          


Ala Ala Gln Arg Ala Glu Pro Arg Ser Gly Arg Gln Arg Val Pro Arg 
        35                  40                  45              


Ala Leu Arg Leu Pro Pro Pro Ala Ser Arg Gly Ser Ser Ser Pro Val 
    50                  55                  60                  


Arg Gly Pro Ser Ser Ser Ala Glu Ser Ser Pro Ser Ser Ser Ala Met 
65                  70                  75                  80  


Ala Gly Trp Asn Ala Tyr Ile Asp Asn Leu Met Ala Asp Gly Thr Cys 
                85                  90                  95      


Gln Asp Ala Ala Ile Val Gly Tyr Lys Asp Ser Pro Ser Val Trp Ala 
            100                 105                 110         


Ala Val Pro Gly Lys Thr Phe Val Asn Ile Thr Pro Ala Glu Val Gly 
        115                 120                 125             


Val Leu Val Gly Lys Asp Arg Ser Ser Phe Tyr Val Asn Gly Leu Thr 
    130                 135                 140                 


Leu Gly Gly Gln Lys Cys Ser Val Ile Arg Asp Ser Leu Leu Gln Asp 
145                 150                 155                 160 


Gly Glu Phe Ser Met 
                165 


<210>  10272
<211>  265
<212>  PRT
<213>  Homo Sapiens

<400>  10272

Met Glu Tyr Phe Gly Thr Ile Gly Ile Gly Thr Pro Ala Gln Asp Phe 
1               5                   10                  15      


Thr Val Val Phe Asp Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Val 
            20                  25                  30          


Tyr Cys Ser Ser Leu Ala Cys Thr Asn His Asn Arg Phe Asn Pro Glu 
        35                  40                  45              


Asp Ser Ser Thr Tyr Gln Ser Thr Ser Glu Thr Val Ser Ile Thr Tyr 
    50                  55                  60                  


Gly Thr Gly Ser Met Thr Gly Ile Leu Gly Tyr Asp Thr Val Gln Val 
65                  70                  75                  80  


Gly Gly Ile Ser Asp Thr Asn Gln Ile Phe Gly Leu Ser Glu Thr Glu 
                85                  90                  95      


Pro Gly Ser Phe Leu Tyr Tyr Ala Pro Phe Asp Gly Ile Leu Gly Leu 
            100                 105                 110         


Ala Tyr Pro Ser Ile Ser Ser Ser Gly Ala Thr Pro Val Phe Asp Asn 
        115                 120                 125             


Ile Trp Asn Gln Gly Leu Val Ser Gln Asp Leu Phe Ser Val Tyr Leu 
    130                 135                 140                 


Ser Ala Asp Asp Gln Ser Gly Ser Val Val Ile Phe Gly Gly Ile Asp 
145                 150                 155                 160 


Ser Ser Tyr Tyr Thr Gly Ser Leu Asn Trp Val Pro Val Thr Val Glu 
                165                 170                 175     


Gly Tyr Trp Gln Ile Thr Val Asp Ser Ile Thr Met Asn Gly Glu Ala 
            180                 185                 190         


Ile Ala Cys Ala Glu Gly Cys Gln Ala Ile Val Asp Thr Gly Thr Ser 
        195                 200                 205             


Leu Leu Thr Gly Pro Thr Ser Pro Ile Ala Asn Ile Gln Ser Asp Ile 
    210                 215                 220                 


Gly Ala Ser Glu Asn Ser Asp Gly Asp Met Val Val Ser Cys Ser Ala 
225                 230                 235                 240 


Ile Ser Ser Leu Pro Asp Ile Val Phe Thr Ile Asn Gly Val Gln Tyr 
                245                 250                 255     


Pro Val Pro Pro Ser Ala Tyr Ile Leu 
            260                 265 


<210>  10273
<211>  388
<212>  PRT
<213>  Homo Sapiens

<400>  10273

Met Lys Trp Leu Leu Leu Leu Gly Leu Val Ala Leu Ser Glu Cys Ile 
1               5                   10                  15      


Met Tyr Lys Val Pro Leu Ile Arg Lys Lys Ser Leu Arg Arg Thr Leu 
            20                  25                  30          


Ser Glu Arg Gly Leu Leu Lys Asp Phe Leu Lys Lys His Asn Leu Asn 
        35                  40                  45              


Pro Ala Arg Lys Tyr Phe Pro Gln Trp Lys Ala Pro Thr Leu Val Asp 
    50                  55                  60                  


Glu Gln Pro Leu Glu Asn Tyr Leu Asp Met Glu Tyr Phe Gly Thr Ile 
65                  70                  75                  80  


Gly Ile Gly Thr Pro Ala Gln Asp Phe Thr Val Val Phe Asp Thr Gly 
                85                  90                  95      


Ser Ser Asn Leu Trp Val Pro Ser Val Tyr Cys Ser Ser Leu Ala Cys 
            100                 105                 110         


Thr Asn His Asn Arg Phe Asn Pro Glu Asp Ser Ser Thr Tyr Gln Ser 
        115                 120                 125             


Thr Ser Glu Thr Val Ser Ile Thr Tyr Gly Thr Gly Ser Met Thr Gly 
    130                 135                 140                 


Ile Leu Gly Tyr Asp Thr Val Gln Val Gly Gly Ile Ser Asp Thr Asn 
145                 150                 155                 160 


Gln Ile Phe Gly Leu Ser Glu Thr Glu Pro Gly Ser Phe Leu Tyr Tyr 
                165                 170                 175     


Ala Pro Phe Asp Gly Ile Leu Gly Leu Ala Tyr Pro Ser Ile Ser Ser 
            180                 185                 190         


Ser Gly Ala Thr Pro Val Phe Asp Asn Ile Trp Asn Gln Gly Leu Val 
        195                 200                 205             


Ser Gln Asp Leu Phe Ser Val Tyr Leu Ser Ala Asp Asp Gln Ser Gly 
    210                 215                 220                 


Ser Val Val Ile Phe Gly Gly Ile Asp Ser Ser Tyr Tyr Thr Gly Ser 
225                 230                 235                 240 


Leu Asn Trp Val Pro Val Thr Val Glu Gly Tyr Trp Gln Ile Thr Val 
                245                 250                 255     


Asp Ser Ile Thr Met Asn Gly Glu Ala Ile Ala Cys Ala Glu Gly Cys 
            260                 265                 270         


Gln Ala Ile Val Asp Thr Gly Thr Ser Leu Leu Thr Gly Pro Thr Ser 
        275                 280                 285             


Pro Ile Ala Asn Ile Gln Ser Asp Ile Gly Ala Ser Glu Asn Ser Asp 
    290                 295                 300                 


Gly Asp Met Val Val Ser Cys Ser Ala Ile Ser Ser Leu Pro Asp Ile 
305                 310                 315                 320 


Val Phe Thr Ile Asn Gly Val Gln Tyr Pro Val Pro Pro Ser Ala Tyr 
                325                 330                 335     


Ile Leu Gln Ser Glu Gly Ser Cys Ile Ser Gly Phe Gln Gly Met Asn 
            340                 345                 350         


Leu Pro Thr Glu Ser Gly Glu Leu Trp Ile Leu Gly Asp Val Phe Ile 
        355                 360                 365             


Arg Gln Tyr Phe Thr Val Phe Asp Arg Ala Asn Asn Gln Val Gly Leu 
    370                 375                 380                 


Ala Pro Val Ala 
385             


<210>  10274
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  10274

Met Asn Gly Glu Ala Ile Ala Cys Ala Glu Gly Cys Gln Ala Ile Val 
1               5                   10                  15      


Asp Thr Gly Thr Ser Leu Leu Thr Gly Pro Thr Ser Pro Ile Ala Asn 
            20                  25                  30          


Ile Gln Ser Asp Ile Gly Ala Ser Glu Asn Ser Asp Gly Asp Met Val 
        35                  40                  45              


Val Ser Cys Ser Ala Ile Ser Ser Leu Pro Asp Ile Val Phe Thr Ile 
    50                  55                  60                  


Asn Gly Val Gln Tyr Pro Val Pro Pro Ser Ala Tyr Ile Leu Gln Ser 
65                  70                  75                  80  


Glu Gly Ser Cys Ile Ser Gly Phe Gln Gly Met Asn Leu Pro Thr Glu 
                85                  90                  95      


Ser Gly Glu Leu Trp Ile Leu Gly Asp Val Phe Ile Arg Gln Tyr Phe 
            100                 105                 110         


Thr Val Phe Asp Arg Ala Asn Asn Gln Val Gly Leu Ala Pro Val Ala 
        115                 120                 125             


<210>  10275
<211>  234
<212>  PRT
<213>  Homo Sapiens

<400>  10275

Met Val Ser Gly Asn Asn Ser Asp Ser Ala His Cys Ile Gly Thr Gly 
1               5                   10                  15      


Leu Arg Gly Lys Glu Thr Thr Leu Val Thr Pro Gln Asp Ser Pro Arg 
            20                  25                  30          


Lys Cys Pro Ile Lys Gly Ser Pro Glu Glu Ala Thr Ala Asp Gly His 
        35                  40                  45              


Thr Asn Gly Arg Thr Lys Lys Phe Met Ser Ser Pro Leu Thr Phe His 
    50                  55                  60                  


Ser Asp Asp Gln Ser Gly Ser Val Val Ile Phe Gly Gly Ile Asp Ser 
65                  70                  75                  80  


Ser Tyr Tyr Thr Gly Ser Leu Asn Trp Val Pro Val Thr Val Glu Gly 
                85                  90                  95      


Tyr Trp Gln Ile Thr Val Asp Ser Ile Thr Met Asn Gly Glu Ala Ile 
            100                 105                 110         


Ala Cys Ala Glu Gly Cys Gln Ala Ile Val Asp Thr Gly Thr Ser Leu 
        115                 120                 125             


Leu Thr Gly Pro Thr Ser Pro Ile Ala Asn Ile Gln Ser Asp Ile Gly 
    130                 135                 140                 


Ala Ser Glu Asn Ser Asp Gly Asp Met Val Val Ser Cys Ser Ala Ile 
145                 150                 155                 160 


Ser Ser Leu Pro Asp Ile Val Phe Thr Ile Asn Gly Val Gln Tyr Pro 
                165                 170                 175     


Val Pro Pro Ser Ala Tyr Ile Leu Gln Ser Glu Gly Ser Cys Ile Ser 
            180                 185                 190         


Gly Phe Gln Gly Met Asn Leu Pro Thr Glu Ser Gly Glu Leu Trp Ile 
        195                 200                 205             


Leu Gly Asp Val Phe Ile Arg Gln Tyr Phe Thr Val Phe Asp Arg Ala 
    210                 215                 220                 


Asn Asn Gln Val Gly Leu Ala Pro Val Ala 
225                 230                 


<210>  10276
<211>  388
<212>  PRT
<213>  Homo Sapiens

<400>  10276

Met Lys Trp Leu Leu Leu Leu Gly Leu Val Ala Leu Ser Glu Cys Ile 
1               5                   10                  15      


Met Tyr Lys Val Pro Leu Ile Arg Lys Lys Ser Leu Arg Arg Thr Leu 
            20                  25                  30          


Ser Glu Arg Gly Leu Leu Lys Asp Phe Leu Lys Lys His Asn Leu Asn 
        35                  40                  45              


Pro Ala Arg Lys Tyr Phe Pro Gln Trp Glu Ala Pro Thr Leu Val Asp 
    50                  55                  60                  


Glu Gln Pro Leu Glu Asn Tyr Leu Asp Met Glu Tyr Phe Gly Thr Ile 
65                  70                  75                  80  


Gly Ile Gly Thr Pro Ala Gln Asp Phe Thr Val Val Phe Asp Thr Gly 
                85                  90                  95      


Ser Ser Asn Leu Trp Val Pro Ser Val Tyr Cys Ser Ser Leu Ala Cys 
            100                 105                 110         


Thr Asn His Asn Arg Phe Asn Pro Glu Asp Ser Ser Thr Tyr Gln Ser 
        115                 120                 125             


Thr Ser Glu Thr Val Ser Ile Thr Tyr Gly Thr Gly Ser Met Thr Gly 
    130                 135                 140                 


Ile Leu Gly Tyr Asp Thr Val Gln Val Gly Gly Ile Ser Asp Thr Asn 
145                 150                 155                 160 


Gln Ile Phe Gly Leu Ser Glu Thr Glu Pro Gly Ser Phe Leu Tyr Tyr 
                165                 170                 175     


Ala Pro Phe Asp Gly Ile Leu Gly Leu Ala Tyr Pro Ser Ile Ser Ser 
            180                 185                 190         


Ser Gly Ala Thr Pro Val Phe Asp Asn Ile Trp Asn Gln Gly Leu Val 
        195                 200                 205             


Ser Gln Asp Leu Phe Ser Val Tyr Leu Ser Ala Asp Asp Gln Ser Gly 
    210                 215                 220                 


Ser Val Val Ile Phe Gly Gly Ile Asp Ser Ser Tyr Tyr Thr Gly Ser 
225                 230                 235                 240 


Leu Asn Trp Val Pro Val Thr Val Glu Gly Tyr Trp Gln Ile Thr Val 
                245                 250                 255     


Asp Ser Ile Thr Met Asn Gly Glu Ala Ile Ala Cys Ala Glu Gly Cys 
            260                 265                 270         


Gln Ala Ile Val Asp Thr Gly Thr Ser Leu Leu Thr Gly Pro Thr Ser 
        275                 280                 285             


Pro Ile Ala Asn Ile Gln Ser Asp Ile Gly Ala Ser Glu Asn Ser Asp 
    290                 295                 300                 


Gly Asp Met Val Val Ser Cys Ser Ala Ile Ser Ser Leu Pro Asp Ile 
305                 310                 315                 320 


Val Phe Thr Ile Asn Gly Val Gln Tyr Pro Val Pro Pro Ser Ala Tyr 
                325                 330                 335     


Ile Leu Gln Ser Glu Gly Ser Cys Ile Ser Gly Phe Gln Gly Met Asn 
            340                 345                 350         


Leu Pro Thr Glu Ser Gly Glu Leu Trp Ile Leu Gly Asp Val Phe Ile 
        355                 360                 365             


Arg Gln Tyr Phe Thr Val Phe Asp Arg Ala Asn Asn Gln Val Gly Leu 
    370                 375                 380                 


Ala Pro Val Ala 
385             


<210>  10277
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  10277

Met Asn Gly Glu Ala Ile Ala Cys Ala Glu Gly Cys Gln Ala Ile Val 
1               5                   10                  15      


Asp Thr Gly Thr Ser Leu Leu Thr Gly Pro Thr Ser Pro Ile Ala Asn 
            20                  25                  30          


Ile Gln Ser Asp Ile Gly Ala Ser Glu Asn Ser Asp Gly Asp Met Val 
        35                  40                  45              


Val Ser Cys Ser Ala Ile Ser Ser Leu Pro Asp Ile Val Phe Thr Ile 
    50                  55                  60                  


Asn Gly Val Gln Tyr Pro Val Pro Pro Ser Ala Tyr Ile Leu Gln Ser 
65                  70                  75                  80  


Glu Gly Ser Cys Ile Ser Gly Phe Gln Gly Met Asn Leu Pro Thr Glu 
                85                  90                  95      


Ser Gly Glu Leu Trp Ile Leu Gly Asp Val Phe Ile Arg Gln Tyr Phe 
            100                 105                 110         


Thr Val Phe Asp Arg Ala Asn Asn Gln Val Gly Leu Ala Pro Val Ala 
        115                 120                 125             


<210>  10278
<211>  234
<212>  PRT
<213>  Homo Sapiens

<400>  10278

Met Val Ser Gly Asn Asn Ser Asp Ser Ala His Cys Ile Gly Thr Gly 
1               5                   10                  15      


Leu Arg Gly Lys Glu Thr Thr Leu Val Thr Pro Gln Asp Ser Pro Arg 
            20                  25                  30          


Lys Cys Pro Ile Lys Gly Ser Pro Glu Glu Ala Thr Ala Asp Gly His 
        35                  40                  45              


Thr Asn Gly Arg Thr Lys Lys Phe Met Ser Ser Pro Leu Thr Phe His 
    50                  55                  60                  


Ser Asp Asp Gln Ser Gly Ser Val Val Ile Phe Gly Gly Ile Asp Ser 
65                  70                  75                  80  


Ser Tyr Tyr Thr Gly Ser Leu Asn Trp Val Pro Val Thr Val Glu Gly 
                85                  90                  95      


Tyr Trp Gln Ile Thr Val Asp Ser Ile Thr Met Asn Gly Glu Ala Ile 
            100                 105                 110         


Ala Cys Ala Glu Gly Cys Gln Ala Ile Val Asp Thr Gly Thr Ser Leu 
        115                 120                 125             


Leu Thr Gly Pro Thr Ser Pro Ile Ala Asn Ile Gln Ser Asp Ile Gly 
    130                 135                 140                 


Ala Ser Glu Asn Ser Asp Gly Asp Met Val Val Ser Cys Ser Ala Ile 
145                 150                 155                 160 


Ser Ser Leu Pro Asp Ile Val Phe Thr Ile Asn Gly Val Gln Tyr Pro 
                165                 170                 175     


Val Pro Pro Ser Ala Tyr Ile Leu Gln Ser Glu Gly Ser Cys Ile Ser 
            180                 185                 190         


Gly Phe Gln Gly Met Asn Leu Pro Thr Glu Ser Gly Glu Leu Trp Ile 
        195                 200                 205             


Leu Gly Asp Val Phe Ile Arg Gln Tyr Phe Thr Val Phe Asp Arg Ala 
    210                 215                 220                 


Asn Asn Gln Val Gly Leu Ala Pro Val Ala 
225                 230                 


<210>  10279
<211>  388
<212>  PRT
<213>  Homo Sapiens

<400>  10279

Met Lys Trp Leu Leu Leu Leu Gly Leu Val Ala Leu Ser Glu Cys Ile 
1               5                   10                  15      


Met Tyr Lys Val Pro Leu Ile Arg Lys Lys Ser Leu Arg Arg Thr Leu 
            20                  25                  30          


Ser Glu Arg Gly Leu Leu Lys Asp Phe Leu Lys Lys His Asn Leu Asn 
        35                  40                  45              


Pro Ala Arg Lys Tyr Phe Pro Gln Trp Glu Ala Pro Thr Leu Val Asp 
    50                  55                  60                  


Glu Gln Pro Leu Glu Asn Tyr Leu Asp Met Glu Tyr Phe Gly Thr Ile 
65                  70                  75                  80  


Gly Ile Gly Thr Pro Ala Gln Asp Phe Thr Val Val Phe Asp Thr Gly 
                85                  90                  95      


Ser Ser Asn Leu Trp Val Pro Ser Val Tyr Cys Ser Ser Leu Ala Cys 
            100                 105                 110         


Thr Asn His Asn Arg Phe Asn Pro Glu Asp Ser Ser Thr Tyr Gln Ser 
        115                 120                 125             


Thr Ser Glu Thr Val Ser Ile Thr Tyr Gly Thr Gly Ser Met Thr Gly 
    130                 135                 140                 


Ile Leu Gly Tyr Asp Thr Val Gln Val Gly Gly Ile Ser Asp Thr Asn 
145                 150                 155                 160 


Gln Ile Phe Gly Leu Ser Glu Thr Glu Pro Gly Ser Phe Leu Tyr Tyr 
                165                 170                 175     


Ala Pro Phe Asp Gly Ile Leu Gly Leu Ala Tyr Pro Ser Ile Ser Ser 
            180                 185                 190         


Ser Gly Ala Thr Pro Val Phe Asp Asn Ile Trp Asn Gln Gly Leu Val 
        195                 200                 205             


Ser Gln Asp Leu Phe Ser Val Tyr Leu Ser Ala Asp Asp Lys Ser Gly 
    210                 215                 220                 


Ser Val Val Ile Phe Gly Gly Ile Asp Ser Ser Tyr Tyr Thr Gly Ser 
225                 230                 235                 240 


Leu Asn Trp Val Pro Val Thr Val Glu Gly Tyr Trp Gln Ile Thr Val 
                245                 250                 255     


Asp Ser Ile Thr Met Asn Gly Glu Thr Ile Ala Cys Ala Glu Gly Cys 
            260                 265                 270         


Gln Ala Ile Val Asp Thr Gly Thr Ser Leu Leu Thr Gly Pro Thr Ser 
        275                 280                 285             


Pro Ile Ala Asn Ile Gln Ser Asp Ile Gly Ala Ser Glu Asn Ser Asp 
    290                 295                 300                 


Gly Asp Met Val Val Ser Cys Ser Ala Ile Ser Ser Leu Pro Asp Ile 
305                 310                 315                 320 


Val Phe Thr Ile Asn Gly Val Gln Tyr Pro Val Pro Pro Ser Ala Tyr 
                325                 330                 335     


Ile Leu Gln Ser Glu Gly Ser Cys Ile Ser Gly Phe Gln Gly Met Asn 
            340                 345                 350         


Val Pro Thr Glu Ser Gly Glu Leu Trp Ile Leu Gly Asp Val Phe Ile 
        355                 360                 365             


Arg Gln Tyr Phe Thr Val Phe Asp Arg Ala Asn Asn Gln Val Gly Leu 
    370                 375                 380                 


Ala Pro Val Ala 
385             


<210>  10280
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  10280

Met Asn Gly Glu Thr Ile Ala Cys Ala Glu Gly Cys Gln Ala Ile Val 
1               5                   10                  15      


Asp Thr Gly Thr Ser Leu Leu Thr Gly Pro Thr Ser Pro Ile Ala Asn 
            20                  25                  30          


Ile Gln Ser Asp Ile Gly Ala Ser Glu Asn Ser Asp Gly Asp Met Val 
        35                  40                  45              


Val Ser Cys Ser Ala Ile Ser Ser Leu Pro Asp Ile Val Phe Thr Ile 
    50                  55                  60                  


Asn Gly Val Gln Tyr Pro Val Pro Pro Ser Ala Tyr Ile Leu Gln Ser 
65                  70                  75                  80  


Glu Gly Ser Cys Ile Ser Gly Phe Gln Gly Met Asn Val Pro Thr Glu 
                85                  90                  95      


Ser Gly Glu Leu Trp Ile Leu Gly Asp Val Phe Ile Arg Gln Tyr Phe 
            100                 105                 110         


Thr Val Phe Asp Arg Ala Asn Asn Gln Val Gly Leu Ala Pro Val Ala 
        115                 120                 125             


<210>  10281
<211>  234
<212>  PRT
<213>  Homo Sapiens

<400>  10281

Met Val Ser Gly Asn Asn Ser Asp Gly Ala His Cys Met Gly Pro Gly 
1               5                   10                  15      


Leu Arg Gly Lys Glu Thr Thr Leu Val Thr Pro Gln Asp Ser Pro Gly 
            20                  25                  30          


Lys Cys Pro Ile Asn Gly Arg Ser Glu Glu Ala Thr Ala Asp Gly His 
        35                  40                  45              


Thr Asn Gly Arg Thr Lys Lys Phe Met Ser Ser Pro Leu Thr Phe His 
    50                  55                  60                  


Ser Asp Asp Lys Ser Gly Ser Val Val Ile Phe Gly Gly Ile Asp Ser 
65                  70                  75                  80  


Ser Tyr Tyr Thr Gly Ser Leu Asn Trp Val Pro Val Thr Val Glu Gly 
                85                  90                  95      


Tyr Trp Gln Ile Thr Val Asp Ser Ile Thr Met Asn Gly Glu Thr Ile 
            100                 105                 110         


Ala Cys Ala Glu Gly Cys Gln Ala Ile Val Asp Thr Gly Thr Ser Leu 
        115                 120                 125             


Leu Thr Gly Pro Thr Ser Pro Ile Ala Asn Ile Gln Ser Asp Ile Gly 
    130                 135                 140                 


Ala Ser Glu Asn Ser Asp Gly Asp Met Val Val Ser Cys Ser Ala Ile 
145                 150                 155                 160 


Ser Ser Leu Pro Asp Ile Val Phe Thr Ile Asn Gly Val Gln Tyr Pro 
                165                 170                 175     


Val Pro Pro Ser Ala Tyr Ile Leu Gln Ser Glu Gly Ser Cys Ile Ser 
            180                 185                 190         


Gly Phe Gln Gly Met Asn Val Pro Thr Glu Ser Gly Glu Leu Trp Ile 
        195                 200                 205             


Leu Gly Asp Val Phe Ile Arg Gln Tyr Phe Thr Val Phe Asp Arg Ala 
    210                 215                 220                 


Asn Asn Gln Val Gly Leu Ala Pro Val Ala 
225                 230                 


<210>  10282
<211>  289
<212>  PRT
<213>  Homo Sapiens

<400>  10282

Met Ala Phe Arg Gln Ala Leu Gln Leu Ala Ala Cys Gly Leu Ala Gly 
1               5                   10                  15      


Gly Ser Ala Ala Val Leu Phe Ser Ala Val Ala Val Gly Lys Pro Arg 
            20                  25                  30          


Ala Gly Gly Asp Ala Glu Pro Arg Pro Ala Glu Pro Pro Ala Trp Ala 
        35                  40                  45              


Gly Gly Ala Arg Pro Gly Pro Gly Val Trp Asp Pro Asn Trp Asp Arg 
    50                  55                  60                  


Arg Glu Pro Leu Ser Leu Ile Asn Val Arg Lys Arg Asn Val Glu Ser 
65                  70                  75                  80  


Gly Glu Glu Glu Leu Ala Ser Lys Leu Asp His Tyr Lys Ala Lys Ala 
                85                  90                  95      


Thr Arg His Ile Phe Leu Ile Arg His Ser Gln Tyr His Val Asp Gly 
            100                 105                 110         


Ser Leu Glu Lys Asp Arg Thr Leu Thr Pro Leu Gly Arg Glu Gln Ala 
        115                 120                 125             


Glu Leu Thr Gly Leu Arg Leu Ala Ser Leu Gly Leu Lys Phe Asn Lys 
    130                 135                 140                 


Ile Val His Ser Ser Met Thr Arg Ala Ile Glu Thr Thr Asp Ile Ile 
145                 150                 155                 160 


Ser Arg His Leu Pro Gly Val Cys Lys Val Ser Thr Asp Leu Leu Arg 
                165                 170                 175     


Glu Gly Ala Pro Ile Glu Pro Asp Pro Pro Val Ser His Trp Lys Pro 
            180                 185                 190         


Glu Ala Val Gln Tyr Tyr Glu Asp Gly Ala Arg Ile Glu Ala Ala Phe 
        195                 200                 205             


Arg Asn Tyr Ile His Arg Ala Asp Ala Arg Gln Glu Glu Asp Ser Tyr 
    210                 215                 220                 


Glu Ile Phe Ile Cys His Ala Asn Val Ile Arg Tyr Ile Val Cys Arg 
225                 230                 235                 240 


Ala Leu Gln Phe Pro Pro Glu Gly Trp Leu Arg Leu Ser Leu Asn Asn 
                245                 250                 255     


Gly Ser Ile Thr His Leu Val Ile Arg Pro Asn Gly Arg Val Ala Leu 
            260                 265                 270         


Arg Thr Leu Gly Asp Thr Gly Phe Met Pro Pro Asp Lys Ile Thr Arg 
        275                 280                 285             


Ser 
    


<210>  10283
<211>  255
<212>  PRT
<213>  Homo Sapiens

<400>  10283

Met Ala Phe Arg Gln Ala Leu Gln Leu Ala Ala Cys Gly Leu Ala Gly 
1               5                   10                  15      


Gly Ser Ala Ala Val Leu Phe Ser Ala Val Ala Val Gly Lys Pro Arg 
            20                  25                  30          


Ala Gly Gly Asp Ala Glu Pro Arg Pro Ala Glu Pro Pro Ala Trp Ala 
        35                  40                  45              


Gly Gly Ala Arg Pro Gly Pro Gly Val Trp Asp Pro Asn Trp Asp Arg 
    50                  55                  60                  


Arg Glu Pro Leu Ser Leu Ile Asn Val Arg Lys Arg Asn Val Glu Ser 
65                  70                  75                  80  


Gly Glu Glu Glu Leu Ala Ser Lys Leu Asp His Tyr Lys Ala Lys Ala 
                85                  90                  95      


Thr Arg His Ile Phe Leu Ile Arg His Ser Gln Tyr His Val Asp Gly 
            100                 105                 110         


Ser Leu Glu Lys Asp Arg Thr Leu Thr Pro Leu Gly Arg Glu Gln Ala 
        115                 120                 125             


Glu Leu Thr Gly Leu Arg Leu Ala Ser Leu Gly Leu Lys Phe Asn Lys 
    130                 135                 140                 


Ile Val His Ser Ser Met Thr Arg Ala Ile Glu Thr Thr Asp Ile Ile 
145                 150                 155                 160 


Ser Arg His Leu Pro Gly Val Cys Lys Val Ser Thr Asp Leu Leu Arg 
                165                 170                 175     


Glu Gly Ala Pro Ile Glu Pro Asp Pro Pro Val Ser His Trp Lys Pro 
            180                 185                 190         


Glu Ala Val Gln Tyr Tyr Glu Asp Gly Ala Arg Ile Glu Ala Ala Phe 
        195                 200                 205             


Arg Asn Tyr Ile His Arg Ala Asp Ala Arg Gln Glu Glu Asp Ser Tyr 
    210                 215                 220                 


Glu Ile Phe Ile Cys His Ala Asn Val Ile Arg Tyr Ile Val Cys Ser 
225                 230                 235                 240 


Ile Pro Pro Leu Leu Ser Ala Gly Asp Phe Val Leu Leu Gly Ser 
                245                 250                 255 


<210>  10284
<211>  140
<212>  PRT
<213>  Homo Sapiens

<400>  10284

Met Thr Arg Ala Ile Glu Thr Thr Asp Ile Ile Ser Arg His Leu Pro 
1               5                   10                  15      


Gly Val Cys Lys Val Ser Thr Asp Leu Leu Arg Glu Gly Ala Pro Ile 
            20                  25                  30          


Glu Pro Asp Pro Pro Val Ser His Trp Lys Pro Glu Ala Val Gln Tyr 
        35                  40                  45              


Tyr Glu Asp Gly Ala Arg Ile Glu Ala Ala Phe Arg Asn Tyr Ile His 
    50                  55                  60                  


Arg Ala Asp Ala Arg Gln Glu Glu Asp Ser Tyr Glu Ile Phe Ile Cys 
65                  70                  75                  80  


His Ala Asn Val Ile Arg Tyr Ile Val Cys Arg Ala Leu Gln Phe Pro 
                85                  90                  95      


Pro Glu Gly Trp Leu Arg Leu Ser Leu Asn Asn Gly Ser Ile Thr His 
            100                 105                 110         


Leu Val Ile Arg Pro Asn Gly Arg Val Ala Leu Arg Thr Leu Gly Asp 
        115                 120                 125             


Thr Gly Phe Met Pro Pro Asp Lys Ile Thr Arg Ser 
    130                 135                 140 


<210>  10285
<211>  140
<212>  PRT
<213>  Homo Sapiens

<400>  10285

Met Thr Arg Ala Ile Glu Thr Thr Asp Ile Ile Ser Arg His Leu Pro 
1               5                   10                  15      


Gly Val Cys Lys Val Ser Thr Asp Leu Leu Arg Glu Gly Ala Pro Ile 
            20                  25                  30          


Glu Pro Asp Pro Pro Val Ser His Trp Lys Pro Glu Ala Val Gln Tyr 
        35                  40                  45              


Tyr Glu Asp Gly Ala Arg Ile Glu Ala Ala Phe Arg Asn Tyr Ile His 
    50                  55                  60                  


Arg Ala Asp Ala Arg Gln Glu Glu Asp Ser Tyr Glu Ile Phe Ile Cys 
65                  70                  75                  80  


His Ala Asn Val Ile Arg Tyr Ile Val Cys Arg Ala Leu Gln Phe Pro 
                85                  90                  95      


Pro Glu Gly Trp Leu Arg Leu Ser Leu Asn Asn Gly Ser Ile Thr His 
            100                 105                 110         


Leu Val Ile Arg Pro Asn Gly Arg Val Ala Leu Arg Thr Leu Gly Asp 
        115                 120                 125             


Thr Gly Phe Met Pro Pro Asp Lys Ile Thr Arg Ser 
    130                 135                 140 


<210>  10286
<211>  269
<212>  PRT
<213>  Homo Sapiens

<400>  10286

Met Ala Gly Leu Ala Ala Arg Leu Val Leu Leu Ala Gly Ala Ala Ala 
1               5                   10                  15      


Leu Ala Ser Gly Ser Gln Gly Asp Arg Glu Pro Val Tyr Arg Asp Cys 
            20                  25                  30          


Val Leu Gln Cys Glu Glu Gln Asn Cys Ser Gly Gly Ala Leu Asn His 
        35                  40                  45              


Phe Arg Ser Arg Gln Pro Ile Tyr Met Ser Leu Ala Gly Trp Thr Cys 
    50                  55                  60                  


Arg Asp Asp Cys Lys Tyr Glu Cys Met Trp Val Thr Val Gly Leu Tyr 
65                  70                  75                  80  


Leu Gln Glu Gly His Lys Val Pro Gln Phe His Gly Lys Val Ser Leu 
                85                  90                  95      


Asn Ala Trp Phe Trp Ser Thr Val Phe His Thr Arg Asp Thr Asp Leu 
            100                 105                 110         


Thr Glu Lys Met Asp Tyr Phe Cys Ala Ser Thr Val Ile Leu His Ser 
        115                 120                 125             


Ile Tyr Leu Cys Cys Val Arg Thr Val Gly Leu Gln His Pro Ala Val 
    130                 135                 140                 


Val Ser Ala Phe Arg Ala Leu Leu Leu Leu Met Leu Thr Val His Val 
145                 150                 155                 160 


Ser Tyr Leu Ser Leu Ile Arg Phe Asp Tyr Gly Tyr Asn Leu Val Ala 
                165                 170                 175     


Asn Val Ala Ile Gly Leu Val Asn Val Val Trp Trp Leu Ala Trp Cys 
            180                 185                 190         


Leu Trp Asn Gln Arg Arg Leu Pro His Val Arg Lys Cys Val Val Val 
        195                 200                 205             


Val Leu Leu Leu Gln Gly Leu Ser Leu Leu Glu Leu Leu Asp Phe Pro 
    210                 215                 220                 


Pro Leu Phe Trp Val Leu Asp Ala His Ala Ile Trp His Ile Ser Thr 
225                 230                 235                 240 


Ile Pro Val His Val Leu Phe Phe Ser Phe Leu Glu Asp Asp Ser Leu 
                245                 250                 255     


Tyr Leu Leu Lys Glu Ser Glu Asp Lys Phe Lys Leu Asp 
            260                 265                 


<210>  10287
<211>  299
<212>  PRT
<213>  Homo Sapiens

<400>  10287

Met Ala Gly Leu Ala Ala Arg Leu Val Leu Leu Ala Gly Ala Ala Ala 
1               5                   10                  15      


Leu Ala Ser Gly Ser Gln Gly Asp Arg Glu Pro Val Tyr Arg Asp Cys 
            20                  25                  30          


Val Leu Gln Cys Glu Glu Gln Asn Cys Ser Gly Gly Ala Leu Asn His 
        35                  40                  45              


Phe Arg Ser Arg Gln Pro Ile Tyr Met Ser Leu Ala Gly Trp Thr Cys 
    50                  55                  60                  


Arg Asp Asp Cys Lys Tyr Glu Cys Met Trp Val Thr Val Gly Leu Tyr 
65                  70                  75                  80  


Leu Gln Glu Gly His Lys Val Pro Gln Phe His Gly Lys Trp Pro Phe 
                85                  90                  95      


Ser Arg Phe Leu Phe Phe Gln Glu Pro Ala Ser Ala Val Ala Ser Phe 
            100                 105                 110         


Leu Asn Gly Leu Ala Ser Leu Val Met Leu Cys Arg Tyr Arg Thr Phe 
        115                 120                 125             


Val Pro Ala Ser Ser Pro Met Tyr His Thr Cys Val Ala Phe Ala Trp 
    130                 135                 140                 


Lys Met Asp Tyr Phe Cys Ala Ser Thr Val Ile Leu His Ser Ile Tyr 
145                 150                 155                 160 


Leu Cys Cys Val Arg Thr Val Gly Leu Gln His Pro Ala Val Val Ser 
                165                 170                 175     


Ala Phe Arg Ala Leu Leu Leu Leu Met Leu Thr Val His Val Ser Tyr 
            180                 185                 190         


Leu Ser Leu Ile Arg Phe Asp Tyr Gly Tyr Asn Leu Val Ala Asn Val 
        195                 200                 205             


Ala Ile Gly Leu Val Asn Val Val Trp Trp Leu Ala Trp Cys Leu Trp 
    210                 215                 220                 


Asn Gln Arg Arg Leu Pro His Val Arg Lys Cys Val Val Val Val Leu 
225                 230                 235                 240 


Leu Leu Gln Gly Leu Ser Leu Leu Glu Leu Leu Asp Phe Pro Pro Leu 
                245                 250                 255     


Phe Trp Val Leu Asp Ala His Ala Ile Trp His Ile Ser Thr Ile Pro 
            260                 265                 270         


Val His Val Leu Phe Phe Ser Phe Leu Glu Asp Asp Ser Leu Tyr Leu 
        275                 280                 285             


Leu Lys Glu Ser Glu Asp Lys Phe Lys Leu Asp 
    290                 295                 


<210>  10288
<211>  148
<212>  PRT
<213>  Homo Sapiens

<400>  10288

Met Ala Gly Leu Ala Ala Arg Leu Val Leu Leu Ala Gly Ala Ala Ala 
1               5                   10                  15      


Leu Ala Ser Gly Ser Gln Gly Asp Arg Glu Pro Val Tyr Arg Asp Cys 
            20                  25                  30          


Val Leu Gln Cys Glu Glu Gln Asn Cys Ser Gly Gly Ala Leu Asn His 
        35                  40                  45              


Phe Arg Ser Arg Gln Pro Ile Tyr Met Ser Leu Ala Gly Trp Thr Cys 
    50                  55                  60                  


Arg Asp Asp Cys Lys Tyr Glu Cys Met Trp Val Thr Val Gly Leu Tyr 
65                  70                  75                  80  


Leu Gln Glu Gly His Lys Val Pro Gln Phe His Gly Lys Trp Pro Phe 
                85                  90                  95      


Ser Arg Phe Leu Phe Phe Gln Glu Pro Ala Ser Ala Val Ala Ser Phe 
            100                 105                 110         


Leu Asn Gly Leu Ala Ser Leu Val Met Leu Cys Arg Tyr Arg Thr Phe 
        115                 120                 125             


Val Pro Ala Ser Ser Pro Met Tyr His Thr Cys Val Ala Phe Ala Trp 
    130                 135                 140                 


Leu Ser Gly Arg 
145             


<210>  10289
<211>  320
<212>  PRT
<213>  Homo Sapiens

<400>  10289

Met Ala Gly Leu Ala Ala Arg Leu Val Leu Leu Ala Gly Ala Ala Ala 
1               5                   10                  15      


Leu Ala Ser Gly Ser Gln Gly Asp Arg Glu Pro Val Tyr Arg Asp Cys 
            20                  25                  30          


Val Leu Gln Cys Glu Glu Gln Asn Cys Ser Gly Gly Ala Leu Asn His 
        35                  40                  45              


Phe Arg Ser Arg Gln Pro Ile Tyr Met Ser Leu Ala Gly Trp Thr Cys 
    50                  55                  60                  


Arg Asp Asp Cys Lys Tyr Glu Cys Met Trp Val Thr Val Gly Leu Tyr 
65                  70                  75                  80  


Leu Gln Glu Gly His Lys Val Pro Gln Phe His Gly Lys Trp Pro Phe 
                85                  90                  95      


Ser Arg Phe Leu Phe Phe Gln Glu Pro Ala Ser Ala Val Ala Ser Phe 
            100                 105                 110         


Leu Asn Gly Leu Ala Ser Leu Val Met Leu Cys Arg Tyr Arg Thr Phe 
        115                 120                 125             


Val Pro Ala Ser Ser Pro Met Tyr His Thr Cys Val Ala Phe Ala Trp 
    130                 135                 140                 


Val Ser Leu Asn Ala Trp Phe Trp Ser Thr Val Phe His Thr Arg Asp 
145                 150                 155                 160 


Thr Asp Leu Thr Glu Lys Met Asp Tyr Phe Cys Ala Ser Thr Val Ile 
                165                 170                 175     


Leu His Ser Ile Tyr Leu Cys Cys Val Arg Thr Val Gly Leu Gln His 
            180                 185                 190         


Pro Ala Val Val Ser Ala Phe Arg Ala Leu Leu Leu Leu Met Leu Thr 
        195                 200                 205             


Val His Val Ser Tyr Leu Ser Leu Ile Arg Phe Asp Tyr Gly Tyr Asn 
    210                 215                 220                 


Leu Val Ala Asn Val Ala Ile Gly Leu Val Asn Val Val Trp Trp Leu 
225                 230                 235                 240 


Ala Trp Cys Leu Trp Asn Gln Arg Arg Leu Pro His Val Arg Lys Cys 
                245                 250                 255     


Val Val Val Val Leu Leu Leu Gln Gly Leu Ser Leu Leu Glu Leu Leu 
            260                 265                 270         


Asp Phe Pro Pro Leu Phe Trp Val Leu Asp Ala His Ala Ile Trp His 
        275                 280                 285             


Ile Ser Thr Ile Pro Val His Val Leu Phe Phe Ser Phe Leu Glu Asp 
    290                 295                 300                 


Asp Ser Leu Tyr Leu Leu Lys Glu Ser Glu Asp Lys Phe Lys Leu Asp 
305                 310                 315                 320 


<210>  10290
<211>  240
<212>  PRT
<213>  Homo Sapiens

<400>  10290

Met Lys Asp Val Gly Pro Glu Ser Cys Gly Gln Pro Thr Pro Cys Trp 
1               5                   10                  15      


Pro Ser Pro Ala Leu Glu Ser Val Leu Gly Lys Ala Ser Gln His Leu 
            20                  25                  30          


Gly Leu Glu Ser Gly Gln Pro Leu Tyr Leu Leu Glu Leu Asn Trp Gly 
        35                  40                  45              


Gly Thr Glu Cys Ala Leu Ser Ser Thr Gly Arg Thr Ala Ala Cys Phe 
    50                  55                  60                  


Leu Pro Ile Ser Leu Leu Pro Thr Ser Pro Ala Ala Trp Leu Gly Pro 
65                  70                  75                  80  


Glu Ala Leu Cys Leu Pro Gly Arg Pro Gly Thr Thr Gly Leu Arg Asp 
                85                  90                  95      


Thr Gly Gly Pro Leu Leu Leu Pro Pro Pro Thr Leu Leu Gln Asp Thr 
            100                 105                 110         


Thr Arg Trp Cys Trp Met Leu Val Leu Trp Pro Ala Lys Val His Gly 
        115                 120                 125             


Asp Ser Pro His Gly Ile Leu Arg Asp Gln Ala Ala Gly Ile Gly Lys 
    130                 135                 140                 


Glu Phe His Pro Asp His Cys Pro Ser Gln Val Pro Arg Arg Pro His 
145                 150                 155                 160 


His Thr Pro Phe Gln Gly Gln Gly Ser Ser Lys Pro Arg Ala Arg Ile 
                165                 170                 175     


Leu Cys Cys Cys Leu Val Glu Ser Leu Pro Pro Cys Val Gly Ser Val 
            180                 185                 190         


Gly Gln Ala Glu Cys Ile Gly Asp Arg Ala Val Ser Met Gly Leu Gly 
        195                 200                 205             


Val Cys Glu Leu Arg Pro Arg Cys Ala Val Trp Arg Arg Val Leu Ser 
    210                 215                 220                 


Gly Lys Arg Cys Gly Phe Lys Val Cys Val Cys Arg Gly Trp Val Cys 
225                 230                 235                 240 


<210>  10291
<211>  70
<212>  PRT
<213>  Homo Sapiens

<400>  10291

Met Trp Val Thr Val Gly Leu Tyr Leu Gln Glu Gly His Lys Val Pro 
1               5                   10                  15      


Gln Phe His Gly Lys Trp Pro Phe Ser Arg Phe Leu Phe Phe Gln Glu 
            20                  25                  30          


Pro Ala Ser Ala Val Ala Ser Phe Leu Asn Gly Leu Ala Ser Leu Val 
        35                  40                  45              


Met Leu Cys Arg Tyr Arg Thr Phe Val Pro Ala Ser Ser Pro Met Tyr 
    50                  55                  60                  


His Thr Cys Val Ala Phe 
65                  70  


<210>  10292
<211>  44
<212>  PRT
<213>  Homo Sapiens

<400>  10292

Ser Phe Leu Asn Gly Leu Ala Ser Leu Val Met Leu Cys Arg Tyr Arg 
1               5                   10                  15      


Thr Phe Val Pro Ala Ser Ser Pro Met Tyr His Thr Cys Val Ala Phe 
            20                  25                  30          


Ala Trp Met Arg Lys Leu Arg His Ser Lys Ala Lys 
        35                  40                  


<210>  10293
<211>  150
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  10293

Xaa Ala Arg Leu Val Leu Leu Ala Gly Ala Ala Ala Leu Ala Ser Gly 
1               5                   10                  15      


Ser Gln Gly Asp Arg Glu Pro Val Tyr Arg Asp Cys Val Leu Gln Cys 
            20                  25                  30          


Glu Glu Gln Asn Cys Ser Gly Gly Ala Leu Asn His Phe Arg Ser Arg 
        35                  40                  45              


Gln Pro Ile Tyr Met Ser Leu Ala Gly Trp Thr Cys Arg Asp Asp Cys 
    50                  55                  60                  


Lys Tyr Glu Cys Met Trp Val Thr Val Gly Leu Tyr Leu Gln Glu Gly 
65                  70                  75                  80  


His Lys Val Pro Gln Phe His Gly Lys Trp Pro Phe Ser Arg Phe Leu 
                85                  90                  95      


Phe Phe Gln Glu Pro Ala Ser Ala Val Ala Ser Phe Leu Asn Gly Leu 
            100                 105                 110         


Ala Ser Leu Val Met Leu Cys Arg Tyr Arg Thr Phe Val Pro Ala Ser 
        115                 120                 125             


Ser Pro Met Tyr His Thr Cys Val Ala Phe Ala Trp Met Arg Lys Leu 
    130                 135                 140                 


Arg His Ser Lys Ala Lys 
145                 150 


<210>  10294
<211>  86
<212>  PRT
<213>  Homo Sapiens

<400>  10294

Met Cys Leu His Pro Ser Ser Thr Pro Pro Phe His Gln Pro Arg Lys 
1               5                   10                  15      


Glu Ala Val Ile Cys Lys Gln Arg Val Pro Leu Lys Lys Phe Lys Ser 
            20                  25                  30          


Ile Arg Glu Thr Met Lys Glu Lys Gly Leu Leu Gly Glu Phe Leu Arg 
        35                  40                  45              


Thr His Lys Tyr Asp Pro Ala Trp Lys Tyr Arg Phe Gly Asp Leu Ser 
    50                  55                  60                  


Val Thr Tyr Glu Pro Met Ala Tyr Met Asp Ala Ala Tyr Phe Gly Glu 
65                  70                  75                  80  


Ile Ser Ile Gly Thr Pro 
                85      


<210>  10295
<211>  315
<212>  PRT
<213>  Homo Sapiens

<400>  10295

Met Lys Trp Met Val Val Val Leu Val Cys Leu Gln Leu Leu Glu Ala 
1               5                   10                  15      


Ala Val Val Lys Val Pro Leu Lys Lys Phe Lys Ser Ile Arg Glu Thr 
            20                  25                  30          


Met Lys Glu Lys Gly Leu Leu Gly Glu Phe Leu Arg Thr His Lys Tyr 
        35                  40                  45              


Asp Pro Ala Trp Lys Tyr Arg Phe Gly Asp Leu Ser Val Thr Tyr Glu 
    50                  55                  60                  


Pro Met Ala Tyr Met Asp Ala Ala Tyr Phe Gly Glu Ile Ser Ile Gly 
65                  70                  75                  80  


Thr Pro Pro Gln Asn Phe Leu Val Leu Phe Asp Thr Gly Ser Ser Asn 
                85                  90                  95      


Leu Trp Val Pro Ser Val Tyr Cys Gln Ser Gln Ala Cys Thr Ser His 
            100                 105                 110         


Ser Arg Phe Asn Pro Ser Glu Ser Ser Thr Tyr Ser Thr Asn Gly Gln 
        115                 120                 125             


Thr Phe Ser Leu Gln Tyr Gly Ser Gly Ser Leu Thr Gly Phe Phe Gly 
    130                 135                 140                 


Tyr Asp Thr Leu Thr Val Gln Ser Ile Gln Val Pro Asn Gln Glu Phe 
145                 150                 155                 160 


Gly Leu Ser Glu Asn Glu Pro Gly Thr Asn Phe Val Tyr Ala Gln Phe 
                165                 170                 175     


Asp Gly Ile Met Gly Leu Ala Tyr Pro Ala Leu Ser Val Asp Glu Ala 
            180                 185                 190         


Thr Thr Ala Met Gln Gly Met Val Gln Glu Gly Ala Leu Thr Ser Pro 
        195                 200                 205             


Val Phe Ser Val Tyr Leu Ser Asn Leu Val Leu Glu Ser Ser Gly Leu 
    210                 215                 220                 


Gly Pro Leu Leu Thr Pro Ser Arg Ala Ala Pro Pro Ser Ser Thr Leu 
225                 230                 235                 240 


Gln Leu Pro Glu Lys Pro Leu Glu Gln Thr Trp Asn Ile Leu Thr Pro 
                245                 250                 255     


Phe Thr Lys Thr Leu Pro Val Ser Asn Leu Ser Arg Lys Val Thr Ser 
            260                 265                 270         


Trp Ala Gly Val Gly Ile Pro Val Thr Cys Leu Pro Glu Ala Gly Ser 
        275                 280                 285             


Gly Gly Glu Arg Arg Ala Glu Cys Gly Leu Gly Val Pro Thr Thr Arg 
    290                 295                 300                 


Gly Pro Pro Arg Ser Gln His His Ser Gly Ala 
305                 310                 315 


<210>  10296
<211>  388
<212>  PRT
<213>  Homo Sapiens

<400>  10296

Met Lys Trp Met Val Val Val Leu Val Cys Leu Gln Leu Leu Glu Ala 
1               5                   10                  15      


Ala Val Val Lys Val Pro Leu Lys Lys Phe Lys Ser Ile Arg Glu Thr 
            20                  25                  30          


Met Lys Glu Lys Gly Leu Leu Gly Glu Phe Leu Arg Thr His Lys Tyr 
        35                  40                  45              


Asp Pro Ala Trp Lys Tyr Arg Phe Gly Asp Leu Ser Val Thr Tyr Glu 
    50                  55                  60                  


Pro Met Ala Tyr Met Asp Ala Ala Tyr Phe Gly Glu Ile Ser Ile Gly 
65                  70                  75                  80  


Thr Pro Pro Gln Asn Phe Leu Val Leu Phe Asp Thr Gly Ser Ser Asn 
                85                  90                  95      


Leu Trp Val Pro Ser Val Tyr Cys Gln Ser Gln Ala Cys Thr Ser His 
            100                 105                 110         


Ser Arg Phe Asn Pro Ser Glu Ser Ser Thr Tyr Ser Thr Asn Gly Gln 
        115                 120                 125             


Thr Phe Ser Leu Gln Tyr Gly Ser Gly Ser Leu Thr Gly Phe Phe Gly 
    130                 135                 140                 


Tyr Asp Thr Leu Thr Val Gln Ser Ile Gln Val Pro Asn Gln Glu Phe 
145                 150                 155                 160 


Gly Leu Ser Glu Asn Glu Pro Gly Thr Asn Phe Val Tyr Ala Gln Phe 
                165                 170                 175     


Asp Gly Ile Met Gly Leu Ala Tyr Pro Ala Leu Ser Val Asp Glu Ala 
            180                 185                 190         


Thr Thr Ala Met Gln Gly Met Val Gln Glu Gly Ala Leu Thr Ser Pro 
        195                 200                 205             


Val Phe Ser Val Tyr Leu Ser Asn Gln Gln Gly Ser Ser Gly Gly Ala 
    210                 215                 220                 


Val Val Phe Gly Gly Val Asp Ser Ser Leu Tyr Thr Gly Gln Ile Tyr 
225                 230                 235                 240 


Trp Ala Pro Val Thr Gln Glu Leu Tyr Trp Gln Ile Gly Ile Glu Glu 
                245                 250                 255     


Phe Leu Ile Gly Gly Gln Ala Ser Gly Trp Cys Ser Glu Gly Cys Gln 
            260                 265                 270         


Ala Ile Val Asp Thr Gly Thr Ser Leu Leu Thr Val Pro Gln Gln Tyr 
        275                 280                 285             


Met Ser Ala Leu Leu Gln Ala Thr Gly Ala Gln Glu Asp Glu Tyr Gly 
    290                 295                 300                 


Gln Phe Leu Val Asn Cys Asn Ser Ile Gln Asn Leu Pro Ser Leu Thr 
305                 310                 315                 320 


Phe Ile Ile Asn Gly Val Glu Phe Pro Leu Pro Pro Ser Ser Tyr Ile 
                325                 330                 335     


Leu Ser Asn Asn Gly Tyr Cys Thr Val Gly Val Glu Pro Thr Tyr Leu 
            340                 345                 350         


Ser Ser Gln Asn Gly Gln Pro Leu Trp Ile Leu Gly Asp Val Phe Leu 
        355                 360                 365             


Arg Ser Tyr Tyr Ser Val Tyr Asp Leu Gly Asn Asn Arg Val Gly Phe 
    370                 375                 380                 


Ala Thr Ala Ala 
385             


<210>  10297
<211>  140
<212>  PRT
<213>  Homo Sapiens

<400>  10297

Met Lys Trp Met Val Val Val Leu Val Cys Leu Gln Leu Leu Glu Ala 
1               5                   10                  15      


Ala Val Val Lys Val Pro Leu Lys Lys Phe Lys Ser Ile Arg Glu Thr 
            20                  25                  30          


Met Lys Glu Lys Gly Leu Leu Gly Glu Phe Leu Arg Thr His Lys Tyr 
        35                  40                  45              


Asp Pro Ala Trp Lys Tyr Arg Phe Gly Asp Leu Ser Val Thr Tyr Glu 
    50                  55                  60                  


Pro Met Ala Tyr Met Asp Val Gln Ser Ile Gln Val Pro Asn Gln Glu 
65                  70                  75                  80  


Phe Gly Leu Ser Glu Asn Glu Pro Gly Thr Asn Phe Val Tyr Ala Gln 
                85                  90                  95      


Phe Asp Gly Ile Met Gly Leu Ala Tyr Pro Ala Leu Ser Val Asp Glu 
            100                 105                 110         


Ala Thr Thr Ala Met Gln Gly Met Val Gln Glu Gly Ala Leu Thr Ser 
        115                 120                 125             


Pro Val Phe Ser Val Tyr Leu Ser Asn Gln Gln Gly 
    130                 135                 140 


<210>  10298
<211>  221
<212>  PRT
<213>  Homo Sapiens

<400>  10298

Met Pro Val Met Arg Leu Phe Pro Cys Phe Leu Gln Leu Leu Ala Gly 
1               5                   10                  15      


Leu Ala Leu Pro Ala Val Pro Pro Gln Gln Trp Ala Leu Ser Ala Gly 
            20                  25                  30          


Asn Gly Ser Ser Glu Val Glu Val Val Pro Phe Gln Glu Val Trp Gly 
        35                  40                  45              


Arg Ser Tyr Cys Arg Ala Leu Glu Arg Leu Val Asp Val Val Ser Glu 
    50                  55                  60                  


Tyr Pro Ser Glu Val Glu His Met Phe Ser Pro Ser Cys Val Ser Leu 
65                  70                  75                  80  


Leu Arg Cys Thr Gly Cys Cys Gly Asp Glu Asn Leu His Cys Val Pro 
                85                  90                  95      


Val Glu Thr Ala Asn Val Thr Met Gln Leu Leu Lys Ile Arg Ser Gly 
            100                 105                 110         


Asp Arg Pro Ser Tyr Val Glu Leu Thr Phe Ser Gln His Val Arg Cys 
        115                 120                 125             


Glu Cys Arg His Ser Pro Gly Arg Gln Ser Pro Asp Met Pro Gly Asp 
    130                 135                 140                 


Phe Arg Ala Asp Ala Pro Ser Phe Leu Pro Pro Arg Arg Ser Leu Pro 
145                 150                 155                 160 


Met Leu Phe Arg Met Glu Trp Gly Cys Ala Leu Thr Gly Ser Gln Ser 
                165                 170                 175     


Ala Val Trp Pro Ser Ser Pro Val Pro Glu Glu Ile Pro Arg Met His 
            180                 185                 190         


Pro Gly Arg Asn Gly Lys Lys Gln Gln Arg Lys Pro Leu Arg Glu Lys 
        195                 200                 205             


Met Lys Pro Glu Arg Cys Gly Asp Ala Val Pro Arg Arg 
    210                 215                 220     


<210>  10299
<211>  149
<212>  PRT
<213>  Homo Sapiens

<400>  10299

Met Pro Val Met Arg Leu Phe Pro Cys Phe Leu Gln Leu Leu Ala Gly 
1               5                   10                  15      


Leu Ala Leu Pro Ala Val Pro Pro Gln Gln Trp Ala Leu Ser Ala Gly 
            20                  25                  30          


Asn Gly Ser Ser Glu Val Glu Val Val Pro Phe Gln Glu Val Trp Gly 
        35                  40                  45              


Arg Ser Tyr Cys Arg Ala Leu Glu Arg Leu Val Asp Val Val Ser Glu 
    50                  55                  60                  


Tyr Pro Ser Glu Val Glu His Met Phe Ser Pro Ser Cys Val Ser Leu 
65                  70                  75                  80  


Leu Arg Cys Thr Gly Cys Cys Gly Asp Glu Asn Leu His Cys Val Pro 
                85                  90                  95      


Val Glu Thr Ala Asn Val Thr Met Gln Leu Leu Lys Ile Arg Ser Gly 
            100                 105                 110         


Asp Arg Pro Ser Tyr Val Glu Leu Thr Phe Ser Gln His Val Arg Cys 
        115                 120                 125             


Glu Cys Arg Pro Leu Arg Glu Lys Met Lys Pro Glu Arg Cys Gly Asp 
    130                 135                 140                 


Ala Val Pro Arg Arg 
145                 


<210>  10300
<211>  170
<212>  PRT
<213>  Homo Sapiens

<400>  10300

Met Pro Val Met Arg Leu Phe Pro Cys Phe Leu Gln Leu Leu Ala Gly 
1               5                   10                  15      


Leu Ala Leu Pro Ala Val Pro Pro Gln Gln Trp Ala Leu Ser Ala Gly 
            20                  25                  30          


Asn Gly Ser Ser Glu Val Glu Val Val Pro Phe Gln Glu Val Trp Gly 
        35                  40                  45              


Arg Ser Tyr Cys Arg Ala Leu Glu Arg Leu Val Asp Val Val Ser Glu 
    50                  55                  60                  


Tyr Pro Ser Glu Val Glu His Met Phe Ser Pro Ser Cys Val Ser Leu 
65                  70                  75                  80  


Leu Arg Cys Thr Gly Cys Cys Gly Asp Glu Asn Leu His Cys Val Pro 
                85                  90                  95      


Val Glu Thr Ala Asn Val Thr Met Gln Leu Leu Lys Ile Arg Ser Gly 
            100                 105                 110         


Asp Arg Pro Ser Tyr Val Glu Leu Thr Phe Ser Gln His Val Arg Cys 
        115                 120                 125             


Glu Cys Arg Pro Leu Arg Glu Lys Met Lys Pro Glu Arg Arg Arg Pro 
    130                 135                 140                 


Lys Gly Arg Gly Lys Arg Arg Arg Glu Lys Gln Arg Pro Thr Asp Cys 
145                 150                 155                 160 


His Leu Cys Gly Asp Ala Val Pro Arg Arg 
                165                 170 


<210>  10301
<211>  169
<212>  PRT
<213>  Homo Sapiens

<400>  10301

Met Pro Val Met Arg Leu Phe Pro Cys Phe Leu Gln Leu Leu Ala Gly 
1               5                   10                  15      


Leu Ala Leu Pro Ala Val Pro Pro Gln Trp Ala Leu Ser Ala Gly Asn 
            20                  25                  30          


Gly Ser Ser Glu Val Glu Val Val Pro Phe Gln Glu Val Trp Gly Arg 
        35                  40                  45              


Ser Tyr Cys Arg Ala Leu Glu Arg Leu Val Asp Val Val Ser Glu Tyr 
    50                  55                  60                  


Pro Ser Glu Val Glu His Met Phe Ser Pro Ser Cys Val Ser Leu Leu 
65                  70                  75                  80  


Arg Cys Thr Gly Cys Cys Gly Asp Glu Asn Leu His Cys Val Pro Val 
                85                  90                  95      


Glu Thr Ala Asn Val Thr Met Gln Leu Leu Lys Ile Arg Ser Gly Asp 
            100                 105                 110         


Arg Pro Ser Tyr Val Glu Leu Thr Phe Ser Gln His Val Arg Cys Glu 
        115                 120                 125             


Cys Arg Pro Leu Arg Glu Lys Met Lys Pro Glu Arg Arg Arg Pro Lys 
    130                 135                 140                 


Gly Arg Gly Lys Arg Arg Arg Glu Lys Gln Arg Pro Thr Asp Cys His 
145                 150                 155                 160 


Leu Cys Gly Asp Ala Val Pro Arg Arg 
                165                 


<210>  10302
<211>  196
<212>  PRT
<213>  Homo Sapiens

<400>  10302

Met Ser Arg Arg Ser Met Leu Leu Ala Trp Ala Leu Pro Ser Leu Leu 
1               5                   10                  15      


Arg Leu Gly Ala Ala Gln Glu Thr Glu Asp Pro Ala Cys Cys Ser Pro 
            20                  25                  30          


Ile Val Pro Arg Asn Glu Trp Lys Ala Leu Ala Ser Glu Cys Ala Gln 
        35                  40                  45              


His Leu Ser Leu Pro Leu Arg Tyr Val Val Val Ser His Thr Ala Gly 
    50                  55                  60                  


Ser Ser Cys Asn Thr Pro Ala Ser Cys Gln Gln Gln Ala Arg Asn Val 
65                  70                  75                  80  


Gln His Tyr His Met Lys Thr Leu Gly Trp Cys Asp Val Gly Tyr Asn 
                85                  90                  95      


Phe Leu Ile Gly Glu Asp Gly Leu Val Tyr Glu Gly Arg Gly Trp Asn 
            100                 105                 110         


Phe Thr Gly Ala His Ser Gly His Leu Trp Asn Pro Met Ser Ile Gly 
        115                 120                 125             


Ile Ser Phe Met Gly Asn Tyr Met Asp Arg Val Pro Thr Pro Gln Ala 
    130                 135                 140                 


Ile Arg Ala Ala Gln Gly Leu Leu Ala Cys Gly Val Ala Gln Gly Ala 
145                 150                 155                 160 


Leu Arg Ser Asn Tyr Val Leu Lys Gly His Arg Asp Val Gln Arg Thr 
                165                 170                 175     


Leu Ser Pro Gly Asn Gln Leu Tyr His Leu Ile Gln Asn Trp Pro His 
            180                 185                 190         


Tyr Arg Ser Pro 
        195     


<210>  10303
<211>  105
<212>  PRT
<213>  Homo Sapiens

<400>  10303

Met Ala Gln Gly Val Leu Trp Ile Leu Leu Gly Leu Leu Leu Trp Ser 
1               5                   10                  15      


Asp Pro Gly Thr Ala Ser Leu Pro Leu Leu Met Asp Ser Val Ile Gln 
            20                  25                  30          


Ala Leu Ala Glu Leu Glu Gln Lys Val Pro Ala Ala Lys Thr Arg His 
        35                  40                  45              


Thr Ala Ser Ala Trp Leu Met Ser Ala Pro Asn Ser Gly Pro His Asn 
    50                  55                  60                  


Arg Leu Tyr His Phe Leu Leu Gly Ala Trp Ser Leu Asn Ala Thr Glu 
65                  70                  75                  80  


Leu Asp Pro Cys Pro Leu Ser Pro Glu Leu Leu Gly Leu Thr Lys Glu 
                85                  90                  95      


Val Ala Arg His Asp Val Arg Glu Gly 
            100                 105 


<210>  10304
<211>  634
<212>  PRT
<213>  Homo Sapiens

<400>  10304

Met Ala Gln Gly Val Leu Trp Ile Leu Leu Gly Leu Leu Leu Trp Ser 
1               5                   10                  15      


Asp Pro Gly Thr Ala Ser Leu Pro Leu Leu Met Asp Ser Val Ile Gln 
            20                  25                  30          


Ala Leu Ala Glu Leu Glu Gln Lys Val Pro Ala Ala Lys Thr Arg His 
        35                  40                  45              


Thr Ala Ser Ala Trp Leu Met Ser Ala Pro Asn Ser Gly Pro His Asn 
    50                  55                  60                  


Arg Leu Tyr His Phe Leu Leu Gly Ala Trp Ser Leu Asn Ala Thr Glu 
65                  70                  75                  80  


Leu Asp Pro Cys Pro Leu Ser Pro Glu Leu Leu Gly Leu Thr Lys Glu 
                85                  90                  95      


Val Ala Arg His Asp Val Arg Glu Gly Lys Glu Tyr Gly Val Val Leu 
            100                 105                 110         


Ala Pro Asp Gly Ser Thr Val Ala Val Glu Pro Leu Leu Ala Gly Leu 
        115                 120                 125             


Glu Ala Gly Leu Gln Gly Arg Arg Val Ile Asn Leu Pro Leu Asp Ser 
    130                 135                 140                 


Met Ala Ala Pro Trp Glu Thr Gly Asp Thr Phe Pro Asp Val Val Ala 
145                 150                 155                 160 


Ile Ala Pro Asp Val Arg Ala Thr Ser Ser Pro Gly Leu Arg Asp Gly 
                165                 170                 175     


Ser Pro Asp Val Thr Thr Ala Asp Ile Gly Ala Asn Thr Pro Asp Ala 
            180                 185                 190         


Thr Lys Gly Cys Pro Asp Val Gln Ala Ser Leu Pro Asp Ala Lys Ala 
        195                 200                 205             


Lys Ser Pro Pro Thr Met Val Asp Ser Leu Leu Ala Val Thr Leu Ala 
    210                 215                 220                 


Gly Asn Leu Gly Leu Thr Phe Leu Arg Gly Ser Gln Thr Gln Ser His 
225                 230                 235                 240 


Pro Asp Leu Gly Thr Glu Gly Cys Trp Asp Gln Leu Ser Ala Pro Arg 
                245                 250                 255     


Thr Phe Thr Leu Leu Asp Pro Lys Ala Ser Leu Leu Thr Met Ala Phe 
            260                 265                 270         


Leu Asn Gly Ala Leu Asp Gly Val Ile Leu Gly Asp Tyr Leu Ser Arg 
        275                 280                 285             


Thr Pro Glu Pro Arg Pro Ser Leu Ser His Leu Leu Ser Gln Tyr Tyr 
    290                 295                 300                 


Gly Ala Gly Val Ala Arg Asp Pro Gly Phe Arg Ser Asn Phe Arg Arg 
305                 310                 315                 320 


Gln Asn Gly Ala Ala Leu Thr Ser Ala Ser Ile Leu Ala Gln Gln Val 
                325                 330                 335     


Trp Gly Thr Leu Val Leu Leu Gln Arg Leu Glu Pro Val His Leu Gln 
            340                 345                 350         


Leu Gln Cys Met Ser Gln Glu Gln Leu Ala Gln Val Ala Ala Asn Ala 
        355                 360                 365             


Thr Lys Glu Phe Thr Glu Ala Phe Leu Gly Cys Pro Ala Ile His Pro 
    370                 375                 380                 


Arg Cys Arg Trp Gly Ala Ala Pro Tyr Arg Gly Arg Pro Lys Leu Leu 
385                 390                 395                 400 


Gln Leu Pro Leu Gly Phe Leu Tyr Val His His Thr Tyr Val Pro Ala 
                405                 410                 415     


Pro Pro Cys Thr Asp Phe Thr Arg Cys Ala Ala Asn Met Arg Ser Met 
            420                 425                 430         


Gln Arg Tyr His Gln Asp Thr Gln Gly Trp Gly Asp Ile Gly Tyr Ser 
        435                 440                 445             


Phe Val Val Gly Ser Asp Gly Tyr Val Tyr Glu Gly Arg Gly Trp His 
    450                 455                 460                 


Trp Val Gly Ala His Thr Leu Gly His Asn Ser Arg Gly Phe Gly Val 
465                 470                 475                 480 


Ala Ile Val Gly Asn Tyr Thr Ala Ala Leu Pro Thr Glu Ala Ala Leu 
                485                 490                 495     


Arg Thr Val Arg Asp Thr Leu Pro Ser Cys Ala Val Arg Ala Gly Leu 
            500                 505                 510         


Leu Arg Pro Asp Tyr Ala Leu Leu Gly His Arg Gln Leu Val Arg Thr 
        515                 520                 525             


Asp Cys Pro Gly Asp Ala Leu Phe Asp Leu Leu Arg Thr Trp Pro His 
    530                 535                 540                 


Phe Thr Ala Val Ser Leu Arg Ser Leu His Tyr Thr Ala Arg Arg Pro 
545                 550                 555                 560 


Ser Val Tyr Thr Ser Ser Thr Arg Pro Leu Pro Pro Ala Cys Asn Ser 
                565                 570                 575     


Cys Ala Arg Thr Ala Ser Ala Arg Pro Pro Thr Ser Arg Arg His Val 
            580                 585                 590         


Tyr Ser Gly Asn Leu Gly Pro Ala Phe Ala Gly His Ser Ala Gly Asn 
        595                 600                 605             


Ile Pro Asp Pro Val Thr Ser Ala Tyr Ala Ala Ser Ala Gln Pro Gln 
    610                 615                 620                 


Thr Gln Pro Ala Cys Pro Phe Pro Ser Ser 
625                 630                 


<210>  10305
<211>  576
<212>  PRT
<213>  Homo Sapiens

<400>  10305

Met Ala Gln Gly Val Leu Trp Ile Leu Leu Gly Leu Leu Leu Trp Ser 
1               5                   10                  15      


Asp Pro Gly Thr Ala Ser Leu Pro Leu Leu Met Asp Ser Val Ile Gln 
            20                  25                  30          


Ala Leu Ala Glu Leu Glu Gln Lys Val Pro Ala Ala Lys Thr Arg His 
        35                  40                  45              


Thr Ala Ser Ala Trp Leu Met Ser Ala Pro Asn Ser Gly Pro His Asn 
    50                  55                  60                  


Arg Leu Tyr His Phe Leu Leu Gly Ala Trp Ser Leu Asn Ala Thr Glu 
65                  70                  75                  80  


Leu Asp Pro Cys Pro Leu Ser Pro Glu Leu Leu Gly Leu Thr Lys Glu 
                85                  90                  95      


Val Ala Arg His Asp Val Arg Glu Gly Lys Glu Tyr Gly Val Val Leu 
            100                 105                 110         


Ala Pro Asp Gly Ser Thr Val Ala Val Glu Pro Leu Leu Ala Gly Leu 
        115                 120                 125             


Glu Ala Gly Leu Gln Gly Arg Arg Val Ile Asn Leu Pro Leu Asp Ser 
    130                 135                 140                 


Met Ala Ala Pro Trp Glu Thr Gly Asp Thr Phe Pro Asp Val Val Ala 
145                 150                 155                 160 


Ile Ala Pro Asp Val Arg Ala Thr Ser Ser Pro Gly Leu Arg Asp Gly 
                165                 170                 175     


Ser Pro Asp Val Thr Thr Ala Asp Ile Gly Ala Asn Thr Pro Asp Ala 
            180                 185                 190         


Thr Lys Gly Cys Pro Asp Val Gln Ala Ser Leu Pro Asp Ala Lys Ala 
        195                 200                 205             


Lys Ser Pro Pro Thr Met Val Asp Ser Leu Leu Ala Val Thr Leu Ala 
    210                 215                 220                 


Gly Asn Leu Gly Leu Thr Phe Leu Arg Gly Ser Gln Thr Gln Ser His 
225                 230                 235                 240 


Pro Asp Leu Gly Thr Glu Gly Cys Trp Asp Gln Leu Ser Ala Pro Arg 
                245                 250                 255     


Thr Phe Thr Leu Leu Asp Pro Lys Ala Ser Leu Leu Thr Met Ala Phe 
            260                 265                 270         


Leu Asn Gly Ala Leu Asp Gly Val Ile Leu Gly Asp Tyr Leu Ser Arg 
        275                 280                 285             


Thr Pro Glu Pro Arg Pro Ser Leu Ser His Leu Leu Ser Gln Tyr Tyr 
    290                 295                 300                 


Gly Ala Gly Val Ala Arg Asp Pro Gly Phe Arg Ser Asn Phe Arg Arg 
305                 310                 315                 320 


Gln Asn Gly Ala Ala Leu Thr Ser Ala Ser Ile Leu Ala Gln Gln Val 
                325                 330                 335     


Trp Gly Thr Leu Val Leu Leu Gln Arg Leu Glu Pro Val His Leu Gln 
            340                 345                 350         


Leu Gln Cys Met Ser Gln Glu Gln Leu Ala Gln Val Ala Ala Asn Ala 
        355                 360                 365             


Thr Lys Glu Phe Thr Glu Ala Phe Leu Gly Cys Pro Ala Ile His Pro 
    370                 375                 380                 


Arg Cys Arg Trp Gly Ala Ala Pro Tyr Arg Gly Arg Pro Lys Leu Leu 
385                 390                 395                 400 


Gln Leu Pro Leu Gly Phe Leu Tyr Val His His Thr Tyr Val Pro Ala 
                405                 410                 415     


Pro Pro Cys Thr Asp Phe Thr Arg Cys Ala Ala Asn Met Arg Ser Met 
            420                 425                 430         


Gln Arg Tyr His Gln Asp Thr Gln Gly Trp Gly Asp Ile Gly Tyr Ser 
        435                 440                 445             


Phe Val Val Gly Ser Asp Gly Tyr Val Tyr Glu Gly Arg Gly Trp His 
    450                 455                 460                 


Trp Val Gly Ala His Thr Leu Gly His Asn Ser Arg Gly Phe Gly Val 
465                 470                 475                 480 


Ala Ile Val Gly Asn Tyr Thr Ala Ala Leu Pro Thr Glu Ala Ala Leu 
                485                 490                 495     


Arg Thr Val Arg Asp Thr Leu Pro Ser Cys Ala Val Arg Ala Gly Leu 
            500                 505                 510         


Leu Arg Pro Asp Tyr Ala Leu Leu Gly His Arg Gln Leu Val Arg Thr 
        515                 520                 525             


Asp Cys Pro Gly Asp Ala Leu Phe Asp Leu Leu Arg Thr Trp Pro His 
    530                 535                 540                 


Phe Thr Ala Thr Val Lys Pro Arg Pro Ala Arg Ser Val Ser Lys Arg 
545                 550                 555                 560 


Ser Arg Arg Glu Pro Pro Pro Arg Thr Leu Pro Ala Thr Asp Leu Gln 
                565                 570                 575     


<210>  10306
<211>  181
<212>  PRT
<213>  Homo Sapiens

<400>  10306

Met Gly Thr Arg Arg Arg Gly Arg Thr Phe His Cys Gln Pro Ser Thr 
1               5                   10                  15      


Ala Glu Val Leu Cys Arg Gly Gln Pro Glu Ile Pro Leu Gly Ser Trp 
            20                  25                  30          


Asn Pro Ala Thr Met Ala Gln Gly Val Leu Trp Ile Leu Leu Gly Leu 
        35                  40                  45              


Leu Leu Trp Ser Asp Pro Gly Thr Ala Ser Leu Pro Leu Leu Met Asp 
    50                  55                  60                  


Ser Val Ile Gln Ala Leu Ala Glu Leu Glu Gln Lys Val Pro Ala Ala 
65                  70                  75                  80  


Lys Thr Arg His Thr Ala Ser Ala Trp Leu Met Ser Ala Pro Asn Ser 
                85                  90                  95      


Gly Pro His Asn Arg Leu Tyr His Phe Leu Leu Gly Ala Trp Ser Leu 
            100                 105                 110         


Asn Ala Thr Glu Leu Asp Pro Cys Pro Leu Ser Pro Glu Leu Leu Gly 
        115                 120                 125             


Leu Thr Lys Glu Val Ala Arg His Asp Val Arg Glu Gly Lys Glu Tyr 
    130                 135                 140                 


Gly Val Val Leu Ala Pro Asp Gly Ser Thr Val Ala Val Glu Pro Leu 
145                 150                 155                 160 


Leu Ala Gly Leu Glu Ala Gly Leu Gln Gly Arg Arg Val Ile Asn Leu 
                165                 170                 175     


Pro Leu Asp Ser Met 
            180     


<210>  10307
<211>  341
<212>  PRT
<213>  Homo Sapiens

<400>  10307

Met Gly Thr Leu Pro Trp Leu Leu Ala Phe Phe Ile Leu Gly Leu Gln 
1               5                   10                  15      


Ala Trp Asp Thr Pro Thr Ile Val Ser Arg Lys Glu Trp Gly Ala Arg 
            20                  25                  30          


Pro Leu Ala Cys Arg Ala Leu Leu Thr Leu Pro Val Ala Tyr Ile Ile 
        35                  40                  45              


Thr Asp Gln Leu Pro Gly Met Gln Cys Gln Gln Gln Ser Val Cys Ser 
    50                  55                  60                  


Gln Met Leu Arg Gly Leu Gln Ser His Ser Val Tyr Thr Ile Gly Trp 
65                  70                  75                  80  


Cys Asp Val Ala Tyr Asn Phe Leu Val Gly Asp Asp Gly Arg Val Tyr 
                85                  90                  95      


Glu Gly Val Gly Trp Asn Ile Gln Gly Leu His Thr Gln Gly Tyr Asn 
            100                 105                 110         


Asn Ile Ser Leu Gly Ile Ala Phe Phe Gly Asn Lys Ile Gly Ser Ser 
        115                 120                 125             


Pro Ser Pro Ala Ala Leu Ser Ala Ala Glu Gly Leu Ile Ser Tyr Ala 
    130                 135                 140                 


Ile Gln Lys Gly His Leu Ser Pro Arg Tyr Ile Gln Pro Leu Leu Leu 
145                 150                 155                 160 


Lys Glu Glu Thr Cys Leu Asp Pro Gln His Pro Val Met Pro Arg Lys 
                165                 170                 175     


Val Cys Pro Asn Ile Ile Lys Arg Ser Ala Trp Glu Ala Arg Glu Thr 
            180                 185                 190         


His Cys Pro Lys Met Asn Leu Pro Ala Lys Tyr Val Ile Ile Ile His 
        195                 200                 205             


Thr Ala Gly Thr Ser Cys Thr Val Ser Thr Asp Cys Gln Thr Val Val 
    210                 215                 220                 


Arg Asn Ile Gln Ser Phe His Met Asp Thr Arg Asn Phe Cys Asp Ile 
225                 230                 235                 240 


Gly Tyr His Phe Leu Val Gly Gln Asp Gly Gly Val Tyr Glu Gly Val 
                245                 250                 255     


Gly Trp His Ile Gln Gly Ser His Thr Tyr Gly Phe Asn Asp Ile Ala 
            260                 265                 270         


Leu Gly Ile Ala Phe Ile Gly Tyr Phe Val Glu Lys Pro Pro Asn Ala 
        275                 280                 285             


Ala Ala Leu Glu Ala Ala Gln Asp Leu Ile Gln Cys Ala Val Val Glu 
    290                 295                 300                 


Gly Tyr Leu Thr Pro Asn Tyr Leu Leu Met Gly His Ser Asp Val Val 
305                 310                 315                 320 


Asn Ile Leu Ser Pro Gly Gln Ala Leu Tyr Asn Ile Ile Ser Thr Trp 
                325                 330                 335     


Pro His Phe Lys His 
            340     


<210>  10308
<211>  369
<212>  PRT
<213>  Homo Sapiens

<400>  10308

Met Leu Pro Trp Leu Leu Val Phe Ser Ala Leu Gly Ile Gln Ala Trp 
1               5                   10                  15      


Gly Asp Ser Ser Trp Asn Lys Thr Gln Ala Lys Gln Val Ser Glu Gly 
            20                  25                  30          


Leu Gln Tyr Leu Phe Glu Asn Ile Ser Gln Leu Thr Glu Lys Asp Val 
        35                  40                  45              


Ser Thr Thr Val Ser Arg Lys Ala Trp Gly Ala Glu Ala Val Gly Cys 
    50                  55                  60                  


Ser Ile Gln Leu Thr Thr Pro Val Asn Val Leu Val Ile His His Val 
65                  70                  75                  80  


Pro Gly Leu Glu Cys His Asp Gln Thr Val Cys Ser Gln Arg Leu Arg 
                85                  90                  95      


Glu Leu Gln Ala His His Val His Asn Asn Ser Gly Cys Asp Val Ala 
            100                 105                 110         


Tyr Asn Phe Leu Val Gly Asp Asp Gly Arg Val Tyr Glu Gly Val Gly 
        115                 120                 125             


Trp Asn Ile Gln Gly Val His Thr Gln Gly Tyr Asn Asn Ile Ser Leu 
    130                 135                 140                 


Gly Phe Ala Phe Phe Gly Thr Lys Lys Gly His Ser Pro Ser Pro Ala 
145                 150                 155                 160 


Ala Leu Ser Ala Met Glu Asn Leu Ile Thr Tyr Ala Val Gln Lys Gly 
                165                 170                 175     


His Leu Ser Ser Ser Tyr Val Gln Pro Leu Leu Gly Lys Gly Glu Asn 
            180                 185                 190         


Cys Leu Ala Pro Arg Gln Lys Thr Ser Leu Lys Lys Ala Cys Pro Gly 
        195                 200                 205             


Val Val Pro Arg Ser Val Trp Gly Ala Arg Glu Thr His Cys Pro Arg 
    210                 215                 220                 


Met Thr Leu Pro Ala Lys Tyr Gly Ile Ile Ile His Thr Ala Gly Arg 
225                 230                 235                 240 


Thr Cys Asn Ile Ser Asp Glu Cys Arg Leu Leu Val Arg Asp Ile Gln 
                245                 250                 255     


Ser Phe Tyr Ile Asp Arg Leu Lys Ser Cys Asp Ile Gly Tyr Asn Phe 
            260                 265                 270         


Leu Val Gly Gln Asp Gly Ala Ile Tyr Glu Gly Val Gly Trp Asn Val 
        275                 280                 285             


Gln Gly Ser Ser Thr Pro Gly Tyr Asp Asp Ile Ala Leu Gly Ile Thr 
    290                 295                 300                 


Phe Met Gly Thr Phe Thr Gly Ile Pro Pro Asn Ala Ala Ala Leu Glu 
305                 310                 315                 320 


Ala Ala Gln Asp Leu Ile Gln Cys Ala Met Val Lys Gly Tyr Leu Thr 
                325                 330                 335     


Pro Asn Tyr Leu Leu Val Gly His Ser Asp Val Ala Arg Thr Leu Ser 
            340                 345                 350         


Pro Gly Gln Ala Leu Tyr Asn Ile Ile Ser Thr Trp Pro His Phe Lys 
        355                 360                 365             


His 
    


<210>  10309
<211>  373
<212>  PRT
<213>  Homo Sapiens

<400>  10309

Met Leu Pro Trp Leu Leu Val Phe Ser Ala Leu Gly Ile Gln Ala Trp 
1               5                   10                  15      


Gly Asp Ser Ser Trp Asn Lys Thr Gln Ala Lys Gln Val Ser Glu Gly 
            20                  25                  30          


Leu Gln Tyr Leu Phe Glu Asn Ile Ser Gln Leu Thr Glu Lys Gly Leu 
        35                  40                  45              


Pro Thr Asp Val Ser Thr Thr Val Ser Arg Lys Ala Trp Gly Ala Glu 
    50                  55                  60                  


Ala Val Gly Cys Ser Ile Gln Leu Thr Thr Pro Val Asn Val Leu Val 
65                  70                  75                  80  


Ile His His Val Pro Gly Leu Glu Cys His Asp Gln Thr Val Cys Ser 
                85                  90                  95      


Gln Arg Leu Arg Glu Leu Gln Ala His His Val His Asn Asn Ser Gly 
            100                 105                 110         


Cys Asp Val Ala Tyr Asn Phe Leu Val Gly Asp Asp Gly Arg Val Tyr 
        115                 120                 125             


Glu Gly Val Gly Trp Asn Ile Gln Gly Val His Thr Gln Gly Tyr Asn 
    130                 135                 140                 


Asn Ile Ser Leu Gly Phe Ala Phe Phe Gly Thr Lys Lys Gly His Ser 
145                 150                 155                 160 


Pro Ser Pro Ala Ala Leu Ser Ala Met Glu Asn Leu Ile Thr Tyr Ala 
                165                 170                 175     


Val Gln Lys Gly His Leu Ser Ser Ser Tyr Val Gln Pro Leu Leu Gly 
            180                 185                 190         


Lys Gly Glu Asn Cys Leu Ala Pro Arg Gln Lys Thr Ser Leu Lys Lys 
        195                 200                 205             


Ala Cys Pro Gly Val Val Pro Arg Ser Val Trp Gly Ala Arg Glu Thr 
    210                 215                 220                 


His Cys Pro Arg Met Thr Leu Pro Ala Lys Tyr Gly Ile Ile Ile His 
225                 230                 235                 240 


Thr Ala Gly Arg Thr Cys Asn Ile Ser Asp Glu Cys Arg Leu Leu Val 
                245                 250                 255     


Arg Asp Ile Gln Ser Phe Tyr Ile Asp Arg Leu Lys Ser Cys Asp Ile 
            260                 265                 270         


Gly Tyr Asn Phe Leu Val Gly Gln Asp Gly Ala Ile Tyr Glu Gly Val 
        275                 280                 285             


Gly Trp Asn Val Gln Gly Ser Ser Thr Pro Gly Tyr Asp Asp Ile Ala 
    290                 295                 300                 


Leu Gly Ile Thr Phe Met Gly Thr Phe Thr Gly Ile Pro Pro Asn Ala 
305                 310                 315                 320 


Ala Ala Leu Glu Ala Ala Gln Asp Leu Ile Gln Cys Ala Met Val Lys 
                325                 330                 335     


Gly Tyr Leu Thr Pro Asn Tyr Leu Leu Val Gly His Ser Asp Val Ala 
            340                 345                 350         


Arg Thr Leu Ser Pro Gly Gln Ala Leu Tyr Asn Ile Ile Ser Thr Trp 
        355                 360                 365             


Pro His Phe Lys His 
    370             


<210>  10310
<211>  580
<212>  PRT
<213>  Homo Sapiens

<400>  10310

Met Asp Tyr Pro Lys Met Asp Tyr Phe Leu Asp Val Glu Ser Ala His 
1               5                   10                  15      


Arg Leu Leu Asp Val Glu Ser Ala Gln Arg Phe Phe Tyr Ser Gln Gly 
            20                  25                  30          


Ala Gln Ala Arg Arg Ala Thr Leu Leu Leu Pro Pro Thr Leu Met Ala 
        35                  40                  45              


Ala Ser Ser Glu Asp Asp Ile Asp Arg Arg Pro Ile Arg Arg Val Arg 
    50                  55                  60                  


Ser Lys Ser Asp Thr Pro Tyr Leu Ala Glu Ala Arg Ile Ser Phe Asn 
65                  70                  75                  80  


Leu Gly Ala Ala Glu Glu Val Glu Arg Leu Ala Ala Met Arg Ser Asp 
                85                  90                  95      


Ser Leu Val Pro Gly Thr His Thr Pro Pro Ile Arg Arg Arg Ser Lys 
            100                 105                 110         


Phe Ala Asn Leu Gly Arg Ile Phe Lys Pro Trp Lys Trp Arg Lys Lys 
        115                 120                 125             


Lys Ser Glu Lys Phe Lys His Thr Ser Ala Ala Leu Glu Arg Lys Ile 
    130                 135                 140                 


Ser Met Arg Gln Ser Arg Glu Glu Leu Ile Lys Arg Gly Val Leu Lys 
145                 150                 155                 160 


Glu Ile Tyr Asp Lys Asp Gly Glu Leu Ser Ile Ser Asn Glu Glu Asp 
                165                 170                 175     


Ser Leu Glu Asn Gly Gln Ser Leu Ser Ser Ser Gln Leu Ser Leu Pro 
            180                 185                 190         


Ala Leu Ser Glu Met Glu Pro Val Pro Met Pro Arg Asp Pro Cys Ser 
        195                 200                 205             


Tyr Glu Val Leu Gln Pro Ser Asp Ile Met Asp Gly Pro Asp Pro Gly 
    210                 215                 220                 


Ala Pro Val Lys Leu Pro Cys Leu Pro Val Lys Leu Ser Pro Pro Leu 
225                 230                 235                 240 


Pro Pro Lys Lys Val Met Ile Cys Met Pro Val Gly Gly Pro Asp Leu 
                245                 250                 255     


Ser Leu Val Ser Tyr Thr Ala Gln Lys Ser Gly Gln Gln Gly Val Ala 
            260                 265                 270         


Gln His His His Thr Val Leu Pro Ser Gln Ile Gln His Gln Leu Gln 
        275                 280                 285             


Tyr Gly Ser His Gly Gln His Leu Pro Ser Thr Thr Gly Ser Leu Pro 
    290                 295                 300                 


Met His Pro Ser Gly Cys Arg Met Ile Asp Glu Leu Asn Lys Thr Leu 
305                 310                 315                 320 


Ala Met Thr Met Gln Arg Leu Glu Ser Ser Glu Gln Arg Val Pro Cys 
                325                 330                 335     


Ser Thr Ser Tyr His Ser Ser Gly Leu His Ser Gly Asp Gly Val Thr 
            340                 345                 350         


Lys Ala Gly Pro Met Gly Leu Pro Glu Ile Arg Gln Val Pro Thr Val 
        355                 360                 365             


Val Ile Glu Cys Asp Asp Asn Lys Glu Asn Val Pro His Glu Ser Asp 
    370                 375                 380                 


Tyr Glu Asp Ser Ser Cys Leu Tyr Thr Arg Glu Glu Glu Glu Glu Glu 
385                 390                 395                 400 


Glu Asp Glu Asp Asp Asp Ser Ser Leu Tyr Thr Ser Ser Leu Ala Met 
                405                 410                 415     


Lys Val Cys Arg Lys Asp Ser Leu Ala Ile Lys Leu Ser Asn Arg Pro 
            420                 425                 430         


Ser Lys Arg Glu Leu Glu Glu Lys Asn Ile Leu Pro Arg Gln Thr Asp 
        435                 440                 445             


Glu Glu Arg Leu Glu Leu Arg Gln Gln Ile Gly Thr Lys Leu Thr Arg 
    450                 455                 460                 


Arg Leu Ser Gln Arg Pro Thr Ala Glu Glu Leu Glu Gln Arg Asn Ile 
465                 470                 475                 480 


Leu Lys Pro Arg Asn Glu Gln Glu Glu Gln Glu Glu Lys Arg Glu Ile 
                485                 490                 495     


Lys Arg Arg Leu Thr Arg Lys Leu Ser Gln Arg Pro Thr Val Glu Glu 
            500                 505                 510         


Leu Arg Glu Arg Lys Ile Leu Ile Arg Phe Ser Asp Tyr Val Glu Val 
        515                 520                 525             


Ala Asp Ala Gln Asp Tyr Asp Arg Arg Ala Asp Lys Pro Trp Thr Arg 
    530                 535                 540                 


Leu Thr Ala Ala Asp Lys Ala Ala Ile Arg Lys Glu Leu Asn Glu Phe 
545                 550                 555                 560 


Lys Ser Thr Glu Met Glu Val His Glu Leu Ser Arg His Leu Thr Arg 
                565                 570                 575     


Phe His Arg Pro 
            580 


<210>  10311
<211>  484
<212>  PRT
<213>  Homo Sapiens

<400>  10311

Met Asp Tyr Pro Lys Met Asp Tyr Phe Leu Asp Val Glu Ser Ala His 
1               5                   10                  15      


Arg Leu Leu Asp Val Glu Ser Ala Gln Arg Phe Phe Tyr Ser Gln Gly 
            20                  25                  30          


Ala Gln Ala Arg Arg Ala Thr Leu Leu Leu Pro Pro Thr Leu Met Ala 
        35                  40                  45              


Ala Ser Ser Glu Asp Asp Ile Asp Arg Arg Pro Ile Arg Arg Val Arg 
    50                  55                  60                  


Ser Lys Ser Asp Thr Pro Tyr Leu Ala Glu Ala Arg Ile Ser Phe Asn 
65                  70                  75                  80  


Leu Gly Ala Ala Glu Glu Val Glu Arg Leu Ala Ala Met Arg Ser Asp 
                85                  90                  95      


Ser Leu Val Pro Gly Thr His Thr Pro Pro Ile Arg Arg Arg Ser Lys 
            100                 105                 110         


Phe Ala Asn Leu Gly Arg Ile Phe Lys Pro Trp Lys Trp Arg Lys Lys 
        115                 120                 125             


Lys Ser Glu Lys Phe Lys His Thr Ser Ala Ala Leu Glu Arg Lys Ile 
    130                 135                 140                 


Ser Met Arg Gln Ser Arg Glu Glu Leu Ile Lys Arg Gly Val Leu Lys 
145                 150                 155                 160 


Glu Ile Tyr Asp Lys Asp Gly Glu Leu Ser Ile Ser Asn Glu Glu Asp 
                165                 170                 175     


Ser Leu Glu Asn Gly Gln Ser Leu Ser Ser Ser Gln Leu Ser Leu Pro 
            180                 185                 190         


Ala Leu Ser Glu Met Glu Pro Val Pro Met Pro Arg Asp Pro Cys Ser 
        195                 200                 205             


Tyr Glu Val Leu Gln Pro Ser Asp Ile Met Asp Gly Pro Asp Pro Gly 
    210                 215                 220                 


Ala Pro Val Lys Leu Pro Cys Leu Pro Val Lys Leu Ser Pro Pro Leu 
225                 230                 235                 240 


Pro Pro Lys Lys Val Met Ile Cys Met Pro Val Gly Gly Pro Asp Leu 
                245                 250                 255     


Ser Leu Val Ser Tyr Thr Ala Gln Lys Ser Gly Gln Gln Gly Val Ala 
            260                 265                 270         


Gln His His His Thr Val Leu Pro Ser Gln Ile Gln His Gln Leu Gln 
        275                 280                 285             


Tyr Gly Ser His Gly Gln His Leu Pro Ser Thr Thr Gly Ser Leu Pro 
    290                 295                 300                 


Met His Pro Ser Gly Cys Arg Met Ile Asp Glu Leu Asn Lys Thr Leu 
305                 310                 315                 320 


Ala Met Thr Met Gln Arg Leu Glu Ser Ser Glu Gln Arg Val Pro Cys 
                325                 330                 335     


Ser Thr Ser Tyr His Ser Ser Gly Leu His Ser Gly Asp Gly Val Thr 
            340                 345                 350         


Lys Ala Gly Pro Met Gly Leu Pro Glu Ile Arg Gln Val Pro Thr Val 
        355                 360                 365             


Val Ile Glu Cys Asp Asp Asn Lys Glu Asn Val Pro His Glu Ser Asp 
    370                 375                 380                 


Tyr Glu Asp Ser Ser Cys Leu Tyr Thr Arg Glu Glu Glu Glu Glu Glu 
385                 390                 395                 400 


Glu Asp Glu Asp Asp Asp Ser Ser Leu Tyr Thr Ser Ser Leu Ala Met 
                405                 410                 415     


Lys Val Cys Arg Lys Asp Ser Leu Ala Ile Lys Leu Ser Asn Arg Pro 
            420                 425                 430         


Ser Lys Arg Glu Leu Glu Glu Lys Asn Ile Leu Pro Arg Gln Thr Asp 
        435                 440                 445             


Glu Glu Arg Leu Glu Leu Arg Gln Gln Ile Gly Thr Lys Leu Thr Arg 
    450                 455                 460                 


Arg Leu Ser Gln Arg Pro Thr Ala Glu Glu Leu Glu Gln Arg Asn Ile 
465                 470                 475                 480 


Leu Lys Arg Lys 
                


<210>  10312
<211>  169
<212>  PRT
<213>  Homo Sapiens

<400>  10312

Met Asp Tyr Pro Lys Met Asp Tyr Phe Leu Asp Val Glu Ser Ala His 
1               5                   10                  15      


Arg Leu Leu Asp Val Glu Ser Ala Gln Arg Phe Phe Tyr Ser Gln Gly 
            20                  25                  30          


Ala Gln Ala Arg Arg Ala Thr Leu Leu Leu Pro Pro Thr Leu Met Ala 
        35                  40                  45              


Ala Ser Ser Glu Asp Asp Ile Asp Arg Arg Pro Ile Arg Arg Val Arg 
    50                  55                  60                  


Ser Lys Ser Asp Thr Pro Tyr Leu Ala Glu Ala Arg Ile Ser Phe Asn 
65                  70                  75                  80  


Leu Gly Ala Gly Val Ser Leu Phe Gly Asp Met Asp Glu Ala Arg Met 
                85                  90                  95      


Gly Pro Ala Val Pro Thr Leu Gly Arg Pro Leu Gly Leu Glu Leu Cys 
            100                 105                 110         


Ser Leu Glu Asn His Gly Leu Leu Lys Thr Ala Pro Thr Tyr Thr Thr 
        115                 120                 125             


Ser Ala His Ile Cys Ser Gly Pro Ser Thr Gly Gly Gln Phe Ser Thr 
    130                 135                 140                 


Gln Gly Met Ser Pro Val Gln Gly Ala Lys Arg Arg Arg Val Val Trp 
145                 150                 155                 160 


Leu Pro Leu Glu Gly Glu Glu Phe Gly 
                165                 


<210>  10313
<211>  144
<212>  PRT
<213>  Homo Sapiens

<400>  10313

Met Tyr Leu Gln Gly Pro Arg Lys Leu Met Thr Gln Gly Gly Tyr Asp 
1               5                   10                  15      


Met Val Gln Lys Leu Phe Leu Asp Phe Phe Arg Arg Arg Leu Ser Gln 
            20                  25                  30          


Arg Pro Thr Ala Glu Glu Leu Glu Gln Arg Asn Ile Leu Lys Pro Arg 
        35                  40                  45              


Asn Glu Gln Glu Glu Gln Glu Glu Lys Arg Glu Ile Lys Arg Arg Leu 
    50                  55                  60                  


Thr Arg Lys Leu Ser Gln Arg Pro Thr Val Glu Glu Leu Arg Glu Arg 
65                  70                  75                  80  


Lys Ile Leu Ile Arg Phe Ser Asp Tyr Val Glu Val Ala Asp Ala Gln 
                85                  90                  95      


Asp Tyr Asp Arg Arg Ala Asp Lys Pro Trp Thr Arg Leu Thr Ala Ala 
            100                 105                 110         


Asp Lys Ala Ala Ile Arg Lys Glu Leu Asn Glu Phe Lys Ser Thr Glu 
        115                 120                 125             


Met Glu Val His Glu Leu Ser Arg His Leu Thr Arg Phe His Arg Pro 
    130                 135                 140                 


<210>  10314
<211>  140
<212>  PRT
<213>  Homo Sapiens

<400>  10314

Met Tyr Leu Gln Gly Pro Arg Lys Leu Met Thr Gln Gly Gly Tyr Asp 
1               5                   10                  15      


Met Val Gln Lys Leu Phe Leu Asp Phe Phe Arg Arg Arg Leu Ser Gln 
            20                  25                  30          


Arg Pro Thr Ala Glu Glu Leu Glu Gln Arg Asn Ile Leu Lys Pro Arg 
        35                  40                  45              


Asn Glu Gln Glu Glu Gln Glu Glu Lys Arg Glu Ile Lys Arg Arg Leu 
    50                  55                  60                  


Thr Arg Lys Leu Ser Gln Arg Pro Thr Val Glu Glu Leu Arg Glu Arg 
65                  70                  75                  80  


Lys Ile Leu Ile Arg Phe Ser Asp Tyr Val Glu Val Ala Asp Ala Gln 
                85                  90                  95      


Asp Tyr Asp Arg Arg Ala Asp Lys Pro Trp Thr Arg Leu Thr Ala Ala 
            100                 105                 110         


Asp Lys Val Ser Arg Gly Glu Cys Trp Arg Val Gly Gly Arg Thr Val 
        115                 120                 125             


Cys Trp Val Ser Leu Gly Ser Pro Leu Gly Ser Val 
    130                 135                 140 


<210>  10315
<211>  230
<212>  PRT
<213>  Homo Sapiens

<400>  10315

Asn Leu Gly Arg Ile Phe Lys Pro Trp Lys Trp Arg Lys Lys Lys Ser 
1               5                   10                  15      


Glu Lys Phe Lys His Thr Ser Ala Ala Leu Glu Arg Lys Ile Ser Met 
            20                  25                  30          


Arg Gln Ser Arg Glu Glu Leu Ile Lys Arg Gly Val Leu Lys Glu Ile 
        35                  40                  45              


Tyr Asp Lys Asp Gly Glu Leu Ser Ile Ser Asn Glu Glu Asp Ser Leu 
    50                  55                  60                  


Glu Asn Gly Gln Ser Leu Ser Ser Ser Gln Leu Ser Leu Pro Ala Leu 
65                  70                  75                  80  


Ser Glu Met Glu Pro Val Pro Met Pro Arg Asp Pro Cys Ser Tyr Glu 
                85                  90                  95      


Val Leu Gln Pro Ser Asp Ile Met Asp Gly Pro Val Ser Glu Glu Ser 
            100                 105                 110         


Pro Ser Ala Ser Glu Ser Gly Val Leu Leu Ser Gln Asp Pro Ser Ala 
        115                 120                 125             


Lys Pro Val Leu Leu Leu Pro Pro Lys Lys Pro Ala Ala Phe Pro Gly 
    130                 135                 140                 


Asp His Glu Glu Thr Pro Val Lys Gln Leu Pro Leu Leu Lys Gln Pro 
145                 150                 155                 160 


Pro Ala Leu Pro Pro Lys Pro Thr Thr Arg Ile Ala Asn His Leu Thr 
                165                 170                 175     


Asp Trp His Gln Ala His Gln Val Gly Gln Arg His Pro Leu Pro Pro 
            180                 185                 190         


Trp Gln Trp Ala Phe Ser Ser Pro Gly Ser Ser Lys Arg Ile Gln Ser 
        195                 200                 205             


Arg Pro Gly Ala Val Ala Tyr Ala Cys Asn Pro Ser Thr Leu Gly Gly 
    210                 215                 220                 


Arg Gly Arg Trp Ile Thr 
225                 230 


<210>  10316
<211>  265
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  10316

Xaa Ser Pro Phe Thr Pro Phe Ser Pro Leu Leu Ser Phe Phe Leu Ser 
1               5                   10                  15      


Pro Phe Phe Phe Leu Phe Pro Ser Leu Ser His Ser Leu Pro Thr Pro 
            20                  25                  30          


Ser Leu Pro Leu Pro Ser Pro Phe Pro Ser Pro Ser Pro Val Arg Glu 
        35                  40                  45              


Pro Leu Pro Leu Pro Ser Ser Pro Phe Arg Leu Ser Pro Ser Pro Ser 
    50                  55                  60                  


Val Ser Phe Ser Leu Ser Ala Arg Arg Ala Thr Leu Leu Leu Pro Pro 
65                  70                  75                  80  


Thr Leu Met Ala Ala Ser Ser Glu Asp Asp Ile Asp Arg Arg Pro Ile 
                85                  90                  95      


Arg Arg Val Arg Ser Lys Ser Asp Thr Pro Tyr Leu Ala Glu Ala Arg 
            100                 105                 110         


Ile Ser Phe Asn Leu Gly Ala Ala Glu Glu Val Glu Arg Leu Ala Ala 
        115                 120                 125             


Met Arg Ser Asp Ser Leu Val Pro Gly Thr His Thr Pro Pro Ile Arg 
    130                 135                 140                 


Arg Arg Ser Lys Phe Ala Asn Leu Gly Arg Ile Phe Lys Pro Trp Lys 
145                 150                 155                 160 


Trp Arg Lys Lys Lys Ser Glu Lys Phe Lys His Thr Ser Ala Ala Leu 
                165                 170                 175     


Glu Arg Lys Ile Ser Met Arg Gln Ser Arg Glu Glu Leu Ile Lys Arg 
            180                 185                 190         


Gly Val Leu Lys Glu Ile Tyr Asp Lys Asp Gly Glu Leu Ser Ile Ser 
        195                 200                 205             


Asn Glu Glu Asp Ser Leu Glu Asn Gly Gln Ser Leu Ser Ser Ser Gln 
    210                 215                 220                 


Leu Ser Leu Pro Ala Leu Ser Glu Met Glu Pro Val Pro Met Pro Arg 
225                 230                 235                 240 


Asp Pro Cys Ser Tyr Glu Val Leu Gln Pro Ser Asp Ile Met Asp Gly 
                245                 250                 255     


Pro Val Ser Glu Glu Ser Pro Ser Ala 
            260                 265 


<210>  10317
<211>  124
<212>  PRT
<213>  Homo Sapiens

<400>  10317

Met Ala Ala Lys Val Phe Glu Ser Ile Gly Lys Phe Gly Leu Ala Leu 
1               5                   10                  15      


Ala Val Ala Gly Gly Val Val Asn Ser Ala Leu Tyr Asn Val Asp Ala 
            20                  25                  30          


Gly His Arg Ala Val Ile Phe Asp Arg Phe Arg Gly Val Gln Asp Ile 
        35                  40                  45              


Val Val Gly Glu Gly Thr His Phe Leu Ile Pro Trp Val Gln Lys Pro 
    50                  55                  60                  


Ile Ile Phe Asp Cys Arg Ser Arg Pro Arg Asn Val Pro Val Ile Thr 
65                  70                  75                  80  


Gly Ser Lys Asp Leu Gln Asn Val Asn Ile Thr Leu Arg Ile Leu Phe 
                85                  90                  95      


Arg Pro Val Ala Ser Gln Leu Pro Arg Ile Phe Thr Ser Ile Gly Glu 
            100                 105                 110         


Asp Tyr Asp Glu Arg Val Leu Pro Ser Ile Thr Thr 
        115                 120                 


<210>  10318
<211>  201
<212>  PRT
<213>  Homo Sapiens

<400>  10318

Met Ala Ala Lys Val Phe Glu Ser Ile Gly Lys Phe Gly Leu Ala Leu 
1               5                   10                  15      


Ala Val Ala Gly Gly Val Val Asn Ser Ala Leu Tyr Asn Val Asp Ala 
            20                  25                  30          


Gly His Arg Ala Val Ile Phe Asp Arg Phe Arg Gly Val Gln Asp Ile 
        35                  40                  45              


Val Val Gly Glu Gly Thr His Phe Leu Ile Pro Trp Val Gln Lys Pro 
    50                  55                  60                  


Ile Ile Phe Asp Cys Arg Ser Arg Pro Arg Asn Val Pro Val Ile Thr 
65                  70                  75                  80  


Gly Ser Lys Asp Leu Gln Asn Val Asn Ile Thr Leu Arg Ile Leu Phe 
                85                  90                  95      


Arg Pro Val Ala Ser Gln Leu Pro Arg Ile Phe Thr Ser Ile Gly Glu 
            100                 105                 110         


Asp Tyr Asp Glu Arg Val Leu Pro Ser Ile Thr Thr Glu Ile Leu Lys 
        115                 120                 125             


Ser Val Val Ala Arg Phe Asp Ala Gly Glu Leu Ile Thr Gln Arg Glu 
    130                 135                 140                 


Leu Val Ser Arg Gln Val Ser Asp Asp Leu Thr Glu Arg Ala Ala Thr 
145                 150                 155                 160 


Phe Gly Leu Ile Leu Asp Asp Val Ser Leu Thr His Leu Thr Phe Gly 
                165                 170                 175     


Lys Glu Phe Thr Glu Ala Val Glu Ala Lys Gln Val Ala Gln Gln Glu 
            180                 185                 190         


Ala Glu Arg Ala Arg Phe Val Val Glu 
        195                 200     


<210>  10319
<211>  202
<212>  PRT
<213>  Homo Sapiens

<400>  10319

Met Ala Ala Lys Val Phe Glu Ser Ile Gly Lys Phe Gly Leu Ala Leu 
1               5                   10                  15      


Ala Val Ala Gly Gly Val Val Asn Ser Ala Leu Tyr Asn Val Asp Ala 
            20                  25                  30          


Gly His Arg Ala Val Ile Phe Asp Arg Phe Arg Gly Val Gln Asp Ile 
        35                  40                  45              


Val Val Gly Glu Gly Thr His Phe Leu Ile Pro Trp Val Gln Lys Pro 
    50                  55                  60                  


Ile Ile Phe Asp Cys Arg Ser Arg Pro Arg Asn Val Pro Val Ile Thr 
65                  70                  75                  80  


Gly Ser Lys Asp Leu Gln Asn Val Asn Ile Thr Leu Arg Ile Leu Phe 
                85                  90                  95      


Arg Pro Val Ala Ser Gln Leu Pro Arg Ile Phe Thr Ser Ile Gly Glu 
            100                 105                 110         


Asp Tyr Asp Glu Arg Val Leu Pro Ser Ile Thr Thr Glu Ile Leu Lys 
        115                 120                 125             


Ser Val Val Ala Arg Phe Asp Ala Gly Glu Leu Ile Thr Gln Arg Glu 
    130                 135                 140                 


Leu Val Ser Arg Gln Val Ser Asp Asp Leu Thr Glu Arg Ala Ala Thr 
145                 150                 155                 160 


Phe Gly Leu Ile Leu Asp Asp Val Ser Leu Thr His Leu Thr Phe Gly 
                165                 170                 175     


Lys Glu Phe Thr Glu Ala Val Glu Ala Lys Gln Val Ala Gln Gln Glu 
            180                 185                 190         


Ala Glu Arg Ala Arg Phe Val Val Glu Lys 
        195                 200         


<210>  10320
<211>  